bluuebunny/crossref_metadata_2025 huggingface dataset:
Toward Hepatitis C Elimination in Marginalized Populations by a Collaborative Multi-setting Approach
Authors: Su Wei-Wen , Yang Chih-Chao , Chang Rene Wei-Jung , Yeh Yung-Hsiang , Yen Hsu-Heng , Yang Chi-Chieh , Lee Yu-Lin , Liu Chun-Eng , Liang Sun-Yuan , Sung Man-Li , Ko Shu-Yu , Kuo Chung-Yang , Chen Sam Li-Sheng , Yeh Yen-Po , Hu Tsung-Hui
Published: September 2022

Background:
Treating marginalized populations with hepatitis C presents a difficult challenge in achieving the 2025 goal of hepatitis C elimination in Taiwan. We report the novel experience of Changhua county in Taiwan in characterizing and treating these populations.
Methods:
The Changhua integrated program to stop HCV infection (CHIPS-C) adopted a multidisciplinary care approach within marginalized populations and enrolled patients from 2019 Jan to 2020 Dec. This model incorporated active collaboration between different teams with gastroenterologists, psychologists, infectious disease doctors, and nursing coordinators.
Results:
There were 303 patients who attended methadone clinics, 3222 persons in correctional institutions, 2853 persons within the national HIV surveillance program (noted as “People under surveillance program”), and 731 HIV-positive patients recruited during the study period. 25.41% (73/303) of methadone clinic patients, 17.65% (129/731) of HIV clinic patients, and 44.3% (41/93) of Group B (deferred prosecuted or probationary people under protective parole) within the “People under surveillance program” category were also recruited into other settings during this period of time. Patients in methadone clinics have the highest seroprevalence of HCV (86%), followed by prisoners (45.23%), patients who attended HIV clinics (35%), and patients within groups of the “People under surveillance program” category (2.94% to 59.52%). Overall, the HCV RNA positivity rate is 70% and the treatment rate is 85%. The proportions of RNA testing and treatment are similar among groups.
Conclusion:
Overlapping characteristics were observed in these populations which highlights that a simultaneous rapid scale-up of treatment was important in these cohorts to lead to HCV elimination.
Long-term Outcomes of Adult Patients following Surgery for Congenital Colorectal Conditions: Analysis of Psychosocial Functioning
Authors: Judd-Glossy Laura , Ariefdjohan Merlin , Ketzer Jill , Wehrli Lea A. , Pena Alberto , Torre Luis de la , Bischoff Andrea
Published: September 2022

Purpose: This study aimed to obtain information about the psychosocial functioning of adults with various congenital colorectal conditions (e.g., anorectal malformation, Hirschsprung disease). Methods: A research registry of adult patients with colorectal conditions was developed. Items included demographics, medical diagnosis/treatment, and measures of anxiety and depression. Descriptive and inferential statistical approaches were applied to summarize data and determine significant differences in the average scores for depression and anxiety between various groupings of diagnoses, gender, race, and the use of psychotropic medication. Results: Study measures were completed by 131 adults. Depression and anxiety scores were significantly higher for women than men and those self-identified as non-binary (p=0.012, <0.001, respectively). No significant differences in depression and anxiety scores were found due to colorectal diagnosis (p>0.05). Participants who identified as Asian had significantly higher depression scores than participants of other races (p=0.002); but no significant difference was noted for anxiety scores (p=0.065). Conclusions: Results suggest that depression and anxiety scores were significantly influenced by gender and race. However, colorectal diagnosis was not a predictor of depression or anxiety. It is important for colorectal providers to be aware of the psychosocial implications of congenital colorectal conditions and consider how to provide adequate support to address patients’ psychosocial needs.
Modeling and Mathematical Analysis of Liquidity Risk Contagionin the Banking System an optimal control
Authors: FAHIM SAID , MOURAD Hamza , LAHBY Mohamed
Published: September 2022

Modeling the spread of contagiousness is well known in epidemiology. However, theapplication of spread modeling to the banking system is quite recent.Optimal control theory analyzes the properties of controlled systems, ie systems on which one canact by means of a command.In this work, we present a liquidity risk problem in the banking system with an optimal controlterm is formulated in order to study the impact of a possible central bank measure in the economy,simulating data from the largest European banks.Then, the proposed approach allows qualitative specifications of contagion in obtaining bankingand adequate analysis and prognosis within the development of the financial and macroeconomicsector as a whole. We show that our model de-reflects the reality of the largest European banks.The simulations were done with optimal control python, and the main results are taken for threedistinct scenarios.
Dual Bioactivity of Angiotensin Converting Enzyme Inhibition and Antioxidant Novel Tripeptides from Sipunculus nudus L and Their Related Mechanism Analysis for Antihypertention
Authors: Liu Huan , Cai xiaoxuan , Huang Miaoen , Wang Tianji , Li Li , Luo Hui , Lu Yingnian
Published: September 2022

The pathogenesis of hypertension is related to many factors including active ACE and excess ROS, the combination of ACE inhibition and antioxidant activity in one compound might be useful for the treatment of hypertension. Sipunculus nudus L contain high protein content, which can be used as a valuable raw material to prepare bio-active peptides. In this study, two novel tripeptides, LPK and PRP, with dual bioactivity of ACE inhibition and antioxidant were purified and identified from Sipunculus nudus L. The antioxidant activities of LPK and PRP are dose-dependent, including DPPH, superoxide anion and hydroxyl radical scavenging activities. Moreover, the antioxidant activity of PRP was stronger than that of LPK. In addition, LPK and PRP also show higher ACE inhibitory activity, with IC50 of 6.54 mM and 0.42 mM, respectively. Molecular docking simulation showed that both the peptides could interact with the active ACE sites via hydrogen bonds, which can reduce the production of Ang II, thereby; LPK and PRP treatment could decrease Ang II-triggered superoxide production, and meanwhile, the peptides treatment could directly remove excess reactive oxygen species. The above-mentioned advantageous effects appeared to involve the stress of the RAS and scavenging ROS, both were benefit to treat hypertension. This research showed that LPK and PRP had potential to be developed as antihypertension agents, which might be a new strategy for high value utilization of Sipunculus nudus L as functional food material.
Disrupted cellulose aggregation leads to the reduced mechanical performance of wood-adhesive interphase during freeze-thaw cycles
Authors: Cao Yizhong , Xu Chuhang , Xu Shuwei , Chen Haili , Yan Yutao , Chen Yifan , Wu Qiang , Wang Siqun
Published: September 2022

The mechanical performance of wooden engineered composites facing the freeze-thaw cycles (FTCs) arises as an attention-worthy issue since the application of timber architectures in cold climates spreads. Here, we reported an investigation to reveal the losses of the mechanical performance of the wood-phenol formaldehyde (PF) adhesive interphase after the FTCs. Results revealed that PF adhesive was barely affected by the FTCs due to the low moisture content and rigid networks, whereas the mechanical properties of the cell wall in wood-PF interphase reduced significantly (more than 30%) after 5 FTCs at -40℃. Cracks were observed in the cell wall and compound middle lamella after FTCs. Further investigation into the crystal structure of the cell wall in the wood-PF interphase demonstrated that the FTCs disrupt the aggregations of cellulose macromolecules. The stresses caused by the phase transition of free water and the external hydrogen bonds formed between water and cellulose disrupted hydrogen bond networks in the cell wall. A plausible mechanism for the FTCs reducing the mechanical properties of the wood-PF bonds can be concluded as the cracks and weakened cell walls crippled the structural integrity of the wood-PF interphase, making it a fragile and stress-concentrated site when subjected to load.
Shedding light on static and dynamic hyperpolarizabilities of thia[7&8]circulenes, toward their NLO applications
Authors: Kosar Naveen , Ayub Khurshid , Gilani Mazhar Amjad , Arshad Muhammad , Mahmood Tariq , Kosar N. K
Published: September 2022

Herein, we examined optoelectronic properties of thia[7&8]circulenes (1-18). Although Circulenes are the elemental building blocks of well-known nanomaterials such as graphene, nanotubes, and fullerenes. Organic chemists have given attention to circulenes during their studies for the improvement and development of aromaticity concept, but NLO properties of these structure-forming circulene subunits are not properly studied. The considered compounds (1-18) are thermodynamically, kinetically and chemically stable. Nonlinear optical (NLO) response is evaluated through static and frequency dependent first and second hyperpolarizabilities analyses. The static first hyperpolarizability (βo) of these compounds ranges between 0.00 – 496.54 au. The frequency dependent coefficients for all thia[7 & 8]circulenes show remarkable enhancement at 532 and 1064 nm, respectively. The nonlinear refractive index is increased up to 1.13×10−14 au for circulene 9 among all thia[7 & 8]circulenes at 532 nm. These findings successfully demonstrated that thia[7&8]circulenes nonlinear optical response can be increased by decorating multiple sulfur atoms. The unsymmetrical distribution of sulfur atoms is more effective as compared to symmetrical distribution.
Comparative effect of inflation versus practice changes on the payments for care: an example from stroke
Authors: Morrow Corey M. , Simpson Annie N. , Almallouhi Eyad , Woodbury Michelle L. , Simpson Kit N.
Published: September 2022

Background: Adjusting for inflation for longitudinal economics analyses is essential to account for changes in monetary valuation. Inflation calculators are common as they provide fast results with minimal resource expenditure. However, their sensitivity to new, high-cost interventions is unknown.Methods: We analyzed hospital payments for acute ischemic stroke survivors from the 2018 5% Medicare Limited Data Sets from the Centers for Medicare and Medicaid Services (CMS). Patients were stratified by severity using the Stroke Administrative Severity Index (SASI) score, which is a validated measure used to describe stroke severity at hospital discharge. Next, we inflated previously published 2014 payments using the US Consumer Price Index: Medical Care (CPI) rates from 2014 to 2018. Results: The inflated 2014 hospital care payments for Mild stroke survivors increased from $6,850 to $7,593, Moderate from $8,456 to $9,373 and Severe from $9,688 to $10,739. After comparing CPI inflated estimates from 2014 to 2018 we found that Mild and Moderate SASI levels were slightly less costly in the true 2018 payments than the inflated 2014 payments, while Severe SASI patients were $2,117 more costly than the 2014 adjusted costs. Our results indicate noteworthy differences in actual versus inflation-adjusted payments particularly for Severe stroke survivors. This is likely due to the emergence and integration of high-cost endovascular thrombectomies (eVT) into standard practice. Conclusions: Though inflation calculators are less resource intensive than cost analyses, they do not necessarily capture true cost changes for stroke survivors. This is one of many reasons that health economists should collaborate with clinicians to discuss clinical factors that may significantly influence longitudinal cost comparisons.
Pediatric Germ Cell Tumors- Pathological Variations and Challenges
Authors: Talat Nabila , Khalid Rija , Tahir Warda , Mirza Muhammad Bilal , Sattar Farrukh Mahmood , Mahmood Adnan , Nayyer Sajid Iqbal , Azam Kamran
Published: September 2022

Aims:Germ cell tumors (GCT) are uncommon in children and adolescent but when they appear, gonads are the most frequent site. Testicular tumors constitute 1-2% of all pediatric solid tumors among them 84% are GCT. Incidence of ovarian GCT is 67%. This study from a single center focus on highlighting clinical features, investigations, treatment and outcome of GCTs in children to look for peri operative challenges and long term prognosis.MethodsA prospective study of 45 patients with GCTs was done from March 2018 to January 2022. The detailed data of each patient was scrutinized including history, physical examination, investigations, management, and follow-up. Forty-five patients presented during this period. Fifteen male (33.3%) and 30(66.7%) female with median age of 4.8 years. Twenty-eight( 62.2%) patients presented with abdominal mass, 15(34.88%) with scrotal swelling and 2(4.65%) with acute abdomen. Hematological and radiological investigations were done in all patients. α-fetoprotein level was high in 30 patients. All patients were managed combinedly with Paediatric Oncology. After being discussed in multidisciplinary tumor board, surgical excision was done.Results:On gross, 75% were mixed and 25% were solid tumors. Median size of testicular tumors ranged from 3cm to 8cm while ovarian tumors ranged from 5cm to 23cm. on histology, Twenty six(57.8%) were mature teratoma, 6 (15.5%) immature teratoma, 8(17.7%) yolk sac tumors, while 1(2.32%) mixed stromal tumor, 1 (2.32%) sex cord tumor and 1(2.2%) Leydig cell tumor also reported. Neo-adjuvant chemo was given in 4 (8.88%) patients while 6 (13.33%) patients received chemotherapy postoperatively. Rest of the patients didnot receive chemotherapy as they had stage I & II disease. Thirty-three patients are doing fine, 11 had lost follow up and 1 patient expired due to sepsis. Long term follow-up with tumor markers and radiological investigations showed no recurrence in majority of patients (73%).ConclusionGCTs in Pediatric population are not uncommon. However good prognosis can be expected if diagnosed at early stage. Majority of tumors doesn’t require post-operative chemotherapy. Tumor markers especially alpha-fetoprotein seems reasonable prognostic marker on follow up in centers where other genetic studies aren’t available due to limited resources.
Assessment of the impacts of ground fissuring in the Main Ethiopian Rift: the case of the rift margin areas of Siltie Zone, southern Ethiopia, East Africa
Authors: Ridwan Munir
Published: September 2022

This paper presents the impact assessment of ground fissuring in rift margin districts of Siltie Zone in southern Ethiopia, which is located at the western margin of the central portion of the Main Ethiopian Rift. Field investigations, literature reviews and interviews were employed in the study. Faults are the major structural units in the area shaping the landscapes as well as determining the size and positions of recent alluvial deposits. The geology of the area is made of rhyolitic ignimbrites at the bottom followed by basalts, and scoria cones are also common. Overlying this stratigraphy are thick unconsolidated alluvial deposits, at places reaching up to 70m and filling grabens created by the regional faulting. Almost all the settlements and agricultural practices are concentrated on this fertile recent sediment. The area is frequently affected by ground fissuring that mainly occur as vertical cracks and ranges from discontinuous hairline fractures to open ground cracks up to 1200m long, as much as 0.5m to 6m wide, and up to 5.2m deep. The fissures are aligned in NNE-SSW directions, the average strike being N16oE. Manmade structures such as homes, water pipelines and storage tankers are destroyed by the fissuring. Agricultural lands and trees are also severely damaged. This heavily affected the food security in the districts since most of the residents are farmers. Some extensions of the fissures however are not exposed to the surface rather formed underground caves and sinkholes and will be future dangers in the area and need proper buffering.
Effects of fetal famine exposure on the cardiovascular disease risk in the metabolic syndrome individuals
Authors: shu zhe , Ding Xiong , Qing Yue , Ma XiaoXu , Liu MinHong , Wu YunTao , Yang Peng , Wu Ying , Li Yun , Wu Shouling
Published: September 2022

Background
Patients with metabolic syndrome (MS) have a higher incidence of cardiovascular disease (CVD), but the possible mechanisms are not fully understood and further exploration of the possible factors influencing the high incidence of CVD in patients with MS is still needed.
Objectives
This study aims to examine the association between fetal famine exposure and the risk of CVD in adulthood in people with MS.
Methods
The 13,744 MS patients free of CVD selected from the Kailuan cohort in 2006 (referred as the baseline survey) were included in the study. All patients were born between January 1, 1949, and December 31, 1974. Based on the date of birth, all patients were divided into the no-exposed group (born between January 1, 1963, and December 31, 1974), uterine famine exposed group (born between January 1, 1959 and December 31, 1962), and childhood famine exposed group (born between January 1, 1949 and December 31, 1958). After following up to December 31, 2019, the weighted Cox regression analysis model was used to calculate the effect of early life famine exposure in MS individuals on the risk of CVD in adulthood.
Results
During the 12.12 years of follow-up, the incidence of CVD was 5.87%, 10.13%, and 10.90% in the no-exposed group, uterine famine exposed group, and childhood famine exposed group, respectively. Compared with participants in the no-exposed group, the CVD risk and stroke risk increased in participants in the uterine famine exposed group (for CVD, HR: 1.32,95% CI:1.04–1.67; for stroke, HR:1.37,95% CI: 1.05–1.79), but not in childhood famine exposed group. However, the increased CVD risks were only observed in females or smokers. No increased MI risks were observed for participants in the uterine famine exposed group or childhood famine exposed group.
Conclusions
Our findings suggested that exposure to famine during fetal life significantly increased the risk of developing CVD in adulthood in individuals with MS, and this association was enhanced in females or smokers.
Blast performance prediction of circular column with improvised equivalent helical mesh transverse reinforcement substituted for single helix, UHPFRC plaster and CFRP wrapping under close-in blast
Authors: Tahzeeb Rafat , Alam Mehtab , Muddassir S.M.
Published: September 2022

The explosion from bombshells develops an excessively high impulsive load on structures. Columns being important key load-bearing members of a structure are vital to providing strength and stability to the building. A circular column performs better than a square/rectangular column under blast loading. Following the validation of experimentally tested square RC column with seismic lateral reinforcement carrying 950kN axial load subjected to an explosive charge of 100kg ANFO (82kg-TNT equivalent) at a scaled distance of 1.00m/kg1/3 with 10mm mesh size using ABAQUS/EXPLICIT software equipped with concrete damage plasticity (CDP) model, an equivalent circular reinforced concrete (RC) column is considered. It is well known that the performance of the circular RC column with single helical transverse reinforcement is superior compared to circular lateral ties. To improve the blast-impact resistance of circular column provision for helical reinforcement mesh using six bars turning successive bars in opposite direction is attempted in this work. The performance of a column with equivalent helical mesh is compared with the column with single helical transverse reinforcement. Further, UHPFRC plaster, as well as CFRP wrapping, are considered on the two columns under the close-in blast loading. The thickness of UHPFRC plaster and CFRP wrapping considered in this study are 15mm and 2mm respectively. The effect of plaster and wrapping on the two columns in terms of confinement of concrete and stresses in longitudinal steel are investigated and compared. Maximum deflection and damage of the columns are predicted.
Importing experimental results via S2D model in ADS tool for Power Amplifier Design
Authors: Bhargava Gaurav , Majumdar Shubhankar , Medjdoub Farid
Published: September 2022

In this paper, behavioral modelling of a power amplifier is implemented by using S2P and S2D model setup. By using the standard power amplifier for obtaining the measured results of Scattering (S-parameters and large signal parameters. These parameters are imported into the S2P and S2D model to perform the small signal and large signal analysis at 3 GHz frequency. Then, the simulated results are compared with the measured results to verify the efficient utilization of behavioral models. The novelty of this work deals with the simulation study of the characteristics of a silicon-based driver amplifier which are obtained directly from the measurements. This work can be utilized to determine the influence of the driver amplifier properties on the power amplifier measurements via simulation. At last, the study of relative error performance analysis between measured and simulated results of different parameters is carried out and calculated of NMSE (in %) for S11, S12, S21, S22, gain, pout, 1 dB compression point, ACP, 3rd harmonics, 4th harmonics, and 5th harmonics are 0.0083, 0.0055, 0.0086, 0.011, 0.0844, 0.814, 0.926, 0.71, 0.22, 0.012 and 0.070 respectively.
Organizational factors associated with delayed therapeutic hypothermia in neonatal hypoxic-ischemic encephalopathy: the LyTONEPAL cohort
Authors: Beck Jonathan , Debillon Thierry , Guellec Isabelle , Vilotitch Antoine , Loron Gauthier , Bednarek Nathalie , Ancel Pierre-Yves , Pierrat Véronique , Ego Anne
Published: September 2022

Initiation of therapeutic hypothermia (TH) within 6 hr of life is a major concern for treating neonatal hypoxic ischemic encephalopathy (HIE). We aimed to determine clinical and organizational factors associated with delayed TH in a French population-based cohort of neonates with moderate or severe HIE. Time to reach a rectal temperature of 34°C defines optimal and delayed (within and > 6 hr) TH. Clinical and organizational factors associated with delayed TH were analysed among neonates born in cooling centres (CCs) and non-cooling centres (non-CCs). Among 629 neonates eligible for TH, 574 received treatment (91.3%). TH was delayed in 29.8% neonates and in 20.3% and 36.2% of those born in CCs and non-CCs, respectively. Neonates with moderate HIE were more exposed to delayed TH in both CCs and non-CCs. After adjustment for HIE severity, maternal and neonatal characteristics and circumstances of birth were not associated with increased risk of delayed TH. However, this risk was 2 to 5 times higher in maternities with < 1999 annual births, when the delay between birth and call for transfer (adjusted odds ratio [aOR] 2.47, 95% confidence interval [CI] [1.03 to 5.96]) or between call for transfer and admission (aOR 6.06, 95%CI [2.60 to 14.12]) was > 3 hr and when an undesirable event occurred during transfer (aOR 2.66, 95%CI [1.11 to 6.37].
Conclusion: Increasing early identification of neonates who could benefit from TH together with access to TH in non-CCs before transfer are modifiable factors that could improve the care of neonates with HIE.
Immune-related interstitial lung disease adverse event following immune checkpoint inhibitors and immune checkpoint inhibitors plus anti-VEGF antibody/chemotherapy: A real-world study from 2014 to 2022 based on FAERS databases
Authors: Cui Chanjuan , Ren Xiayang , Cui Wei , Wang Yanfeng
Published: September 2022

Purpose
This study further approaches immune-related interstitial lung disease adverse event (AE) in patients undergoing immune checkpoint inhibitor (ICI) monotherapy, ICI plus chemotherapy and ICI plus anti-VEGF therapy in the postmarketing period.
Methods
This study analysed reports for ICI-related interstitial lung disease AE from the FDA Adverse Event Reporting System (FAERS) database between 2014 and 2022. The reporting odds ratio (ROR) and Bayesian confidence propagation neural networks of information components (IC) were computed to identify disproportionate reporting of ICI-related interstitial lung disease.
Results
44,964,609 records were extracted from the FAERS database, with 9150 records for interstitial lung disease after ICI treatment. Men had a slightly higher reporting frequency than women (63.07% vs. 25.69%). The morbidity rate (2.05%) of acute respiratory distress syndrome was low, the fatality rate (67.55%) was the highest, the time to onset was relatively short. Within 3 months, the cumulative proportion of ICI-related interstitial lung disease records was 75.03%. The ICI plus anti-VEGF therapy group had the lowest frequency of interstitial lung disease AEs compared to the ICI monotherapy group and the ICI plus chemotherapy group (IC025 = 1.72, IC025 = 3.21, IC025 = 3.22). Moreover, ICI plus anti-VEGF therapy group had the narrowest spectrum of interstitial lung disease among these three therapeutic regimens.
Conclusion
This study showed a high reporting frequency and substantial characteristics of a spectrum of interstitial lung disease AEs after different ICI regimens. Notably, ICI plus anti-VEGF therapy might be a treatment method that can to some extent control ICI-related interstitial lung disease. These data provide some important information for clinicians to weigh the risks and benefits of different ICI regimens.
Characteristics of Appendicitis after Immune Checkpoint Inhibitor Therapy among Cancer Patients
Authors: Mathew Antony , Shatila Malek , Lai Zongshan , Tan Dongfeng , Oliva Isabella C. Glitza , Wang Jianbo , Alhalabi Omar , Zhang Hao Chi , Thomas Anusha , Wang Yinghong
Published: September 2022

PurposeImmune checkpoint inhibitor (ICI) therapy has revolutionized cancer care but is associated with immune-related adverse events (irAEs). Recent case reports raised the concern that acute appendicitis may be an irAE. In this study, we sought to describe the disease course of post-ICI therapy appendicitis and its associated complications.Methods Adult patients who had an International Classification of Diseases code for appendicitis within the first 2 years after initiating ICI therapy from January 2010 to April 2021 and who had imaging evidence of appendicitis were studied retrospectively. Results 13,991 patients were identified who had ICI exposure during the study period, 44 had codes for appendicitis, 10 of whom met the inclusion criteria. Their median age at the time of diagnosis was 59 years. The median time from ICI therapy initiation to appendicitis onset was 188 days. The most common presenting symptoms were abdominal pain (70%) and fever (40%). Abscesses were present in two patients, and a perforation was present in one. All 10 patients received broad-spectrum antibiotics. Five patients needed surgery or interventional radiology drainage. Nine patients had resolution of appendicitis symptoms after treatment. ConclusionPost-ICI therapy appendicitis is rare but presents similarly to and has similar complications rates as conventional appendicitis. Appendectomy remains the mainstay of treatment, but its use can be limited in cancer patients. The decision to continue ICI therapy remains at the discretion of the clinician. Further studies are needed to bring awareness to and advance the understanding of this clinical entity.
Impact of covid-19 confinement on physical activity in Spanish breast cancer survivors
Authors: de Arrilucea Unai Pérez , Serradilla Ana , Tórtola-Navarro Aida
Published: September 2022

Purpose: To analyse changes in PA habits during COVID-19 confinement in a sample of Spanish breast cancer survivors and whether these changes have led to differences in current physical activity practice.Methods: This is a descriptive study using an ad hoc survey. Sociodemographic, clinical and physical activity variables were recorded in a sample of breast cancer survivors over 18 years old, independently of treatment and diagnosed stage. Final sample was 124 women, most of whom had completed the treatments.Results: There was a significant decrease in physical activity level of Spanish breast cancer survivors during confinement. However, there were no significance comparing pre and post confinement periods. In all periods those women who trained under supervision had a higher level of physical activity. Comparing pre and post periods, more survivors performing their training outdoors after confinement. Before confinement, training location influenced survivors who trained in sport centres did so at a higher intensity and for longer periods. After confinement, the training location only influenced the duration of training. Conclusion: During COVID-19 confinement there was significative changes in the physical activity habits of Spanish breast cancer survivors. However, the only change from before the confinement was the location.
Influence of seed variety and extraction technique on fatty acid distribution and quality parameters of tropical castor (Ricinus communis L.) oils
Authors: Jolayemi Olusola Samuel , Alagbe Caleb Iyanu
Published: September 2022

Industrial application of castor oil is anchored on both agronomical and technological variables that intrinsically influence its quality properties. Therefore, castor oils of two varieties (Gibsoni and Carmenicita), extracted by screw press, solvent and traditional methods were compared in terms of oxidative stability indices, quality parameters and fatty acid distributions. General factorial analyses showed the significance of both factors on the oil yield, color intensity, moisture content, oxidative stability indices, most of the oil’s fatty acids and other quality parameters. Gibsoni variety yielded more oil at the range of 40.12–53.51%, especially in solvent extraction. The two oxidative stability indicators; peroxide value (PeV) and free fatty acids (FFA) favored traditional extraction and were significantly higher in oils of Carmenicita variety, at 4.26–7.21 meqO2/kg and 2.55–3.94%, respectively. In addition to ricinoleic acid (85.93–89.19%), other fatty acids characterized in the oils include, oleic (4.73–5.84%), stearic (1.41–2.50%), linoleic (1.08–3.41%), and palmitic acids (0.60–1.29%). Saponification (SaV) and iodine values (IoV) of the oils were unaffected by varietal differences or extraction processes and the ranges recorded in both varieties were within ASTM (175–187 mgKOH/g) and EN 14214 (120–140 g I2/100g) acceptable limits. Principal component analysis (PCA) model built on the data of the oils further emphasized the significance of these two factors in quality characterization of castor oil.
Classification of COVID-19 from Chest X-Ray Images Using Deep Learning Techniques
Authors: Gelgelo Jarso , Diriba Chala , Bayisa JJermia
Published: September 2022

COVID-19 is an outbreak and pandemic disease transmitted through the air and by physical contact. The aim of this study was to develop an automatic classification of COVID-19 from digital medical of chest X-ray images using deep learning techniques. The techniques that were used in this study are, image preprocessing, data augmentation, and data preparation. Proposed Convolutional Neural network Model and Two pretrained Convolutional Neural network, which are VGG16, and Inception, were selected and fine-tuned with data augmentation to carry out 2-class classification tasks using chest X-ray images. From this, 80% of the images are used for training and the rest for testing the model. The features extracted are fit into the neural network with 500 epochs, 80/20 splitting ratio, and 0.001 learning rate. Convolutional Neural network model achieved with the Inception-V3 of 98.16% average training accuracy as compared to VGG16 with 93.65% and proposed convolutional neural network classifier with 73.85%. The experimental result showed that the overall Inception-V3 classifier yielded the highest performance evaluation of 95.4% accuracy as compared to VGG16 (with 93.08%) and Convolutional Neural network proposed model classifier (with 55%). The future work will look into the problem the number of images and the bigger the number of the images is, the better the model is trained from scratch.
The efficacy and safety of vascular endothelial growth factor receptor inhibitors (VEGFRIs) for recurrent ovarian cancer: a systematic review
Authors: Tan Linlin , Ni Yuchun , Yan Jiaqi , Wu Mei , Huang Zhaowei , Zhang Zhipeng , Zhang Fupeng , Wang Zhijie
Published: September 2022

Background Vascular endothelial growth factor receptor inhibitors (VEGFRIs) have been common used for recurrent ovarian cancer (ROC), but insufficient high-level evidence on verifying its efficacy and safety. This systematic review (SR) aimed to evaluate the efficacy and safety of VEGFRIs for ROC.
Methods Randomized controlled trials (RCTs) were searched under eight electronic databases from their inceptions to 30th June 2021. Outcomes were included progression-free survival (PFS), overall survival (OS), objective response rate (ORR), disease control rate (DCR), quality of life (QoL), and adverse events (AEs). We calculated pooled hazard ratio (HR) and risk ratio (RR) with 95% confidence interval (CI) by Stata 14.0 and Review Manager 5.4. This systematic review was registered under INPLASY (INPLASY202120019).
Results Totally 19 RCTs involving 2125 patients were included in this SR. It demonstrated that VEGFRIs may improve PFS and OS of ROC patients both in platinum-sensitive group and platinum-resistant group. Compared to control groups, using VEGFRIs could significantly improve ORR, DCR, and QoL of the patients with ROC. Twenty two kinds of grade 3 or higher severity AEs were compared between VEGFRIs group and control groups, 14 (63.63%) of them showed no significant difference, and eight (36.36%) showed more in VEGFRIs groups. Raising gamma-glutamyl transferase, hand-foot syndrome and hypertension were with the highest incidence.
Conclusion This SR suggests VEGFRIs may be a recommended therapy for ROC because of improving PFS, OS, the clinical response, and QoL. Thought VEGFRIs increase some drug-related AEs, all the AEs could be manageable in the clinical practice.
The Efficiency of Collaborative Assembling Cells
Authors: Andrusyshyn Vladyslav , Luscinski Slawomir , Ivanov Vitalii , Pavlenko Ivan
Published: September 2022

To produce competitive products, it is necessary to consider their permanent modernization and adaptation to the emerging needs of a consumer. This feature of up-to-date production inevitably leads to design complexities. As a result, the complexity of a technological assembly process increases, which is a new challenge for enterprises. Simultaneously, in most cases, assembly operations are performed manually due to the complexity or impossibility of automating the assembling process for an extensive range of products. This fact is due to the insufficient flexibility of automation systems. Remarkably, this approach has significant drawbacks, i.e., low productivity and risk of chronic diseases. To solve this problem, the use of collaborative systems was proposed. Such systems have the advantages of both humans and automation tools. As a result, industrial robots can be applied as automation tools. However, when using industrial robots next to workers, the safety requirements are significantly increased since the infliction of industrial injuries is unacceptable. After considering all the above, the article deals with a new scientific and methodological approach to designing security systems of collaborative production cells and their design and effectiveness verification.
Does COVID-19 drive the US corporate-government bonds yield correlations? Local and global reporting
Authors: Alkhataybeh Ahmad , Ur Rehman Mobeen , El-Nader Ghaith , Alrababa’a Abedalrazaq , Alomari Mohammad
Published: September 2022

This paper investigates whether the COVID-19 cases and death rates affect the dynamic correlation of corporate-government bond yields. Therefore, this study uses the daily corporate bond data with different ratings of bonds along with the COVID-19 data at both the US and global levels. Using the quantile regression approach, it produces the following results. First, the impact of daily cases differs from that of death rates both locally and globally. Second, the impact of local cases and death cases on the government-AAA yields correlation at a given quantile tends to reverse when the BBB bonds are used in the analysis. Third, global death rates significantly affect the correlation series the most at the higher quantiles. Lastly, AAA-rated bonds show higher sensitivity to COVID-19 cases and death rates than BBB-rated bonds. This finding indicates that relatively high-quality bonds are more susceptible to the pandemic period and thus calls for careful evaluation of assets included in investors’ portfolios. This study assumes that local COVID-19 data provide a better implication for constructing bond portfolios than global data. That is, their economic impact depends on the rating of the bond and tends to vary more across correlation quantiles.
Postmortem diagnosis of gunshot injuries in great black cormorant (Phalacrocorax carbo) for forensic veterinary medicine
Authors: FELSMANN MARIUSZ Z. , ZDUN MACIEJ , WĄSIATYCZ GRZEGORZ , ANDRZEJEWSKI WOJCIECH
Published: September 2022

Veterinarians rarely have the opportunity to examine shot animals. This inexperience makes it difficult to assess such cases. Based on the example of postmortem examinations of shot cormorants (Phalacrocorax carbo), the authors indicated the elements necessary for the proper diagnosis of gunshot wounds in birds. The study used mixed diagnostic techniques, including imaging diagnostics. Postmortem examinations of the corpses of 80 black cormorants obtained as a result of shooting with lead shot ammunition have been carried out. Autopsies and imaging examinations were performed. The results of the research were presented in the context of the needs of forensic veterinary medicine. Attention was paid to the characteristic anatomical changes caused by shotgun shells in the bodies of the birds. In addition, possible mistakes made during postmortem assessment of bird corpses were indicated. The method of using imaging techniques (X-ray and CT) in the diagnosis of gunshot wounds was presented. The possibility of using other imaging techniques, in doubtful cases that do not confirm gunshot wounds, was also indicated.
Orientalizing Arab Migrant Women: Faten and Reema as Sexual Fantasies in Laila Lalami’s Hope and Other Dangerous Pursuits and Susan Muaddi Darraj’s The Inheritance of Exile
Authors: Lamghari Rachid
Published: September 2022

The orientalist discourse is characterized by the discursive conceptualization of an uncivilized and sexualized east. Eastern women are portrayed as sexual objects and fantasies whose purpose is the satisfaction and obedience of the brown men. This discursive representation has affected the Westerner’s perception of migrant women as the novels suggest. This article probes the sexualizing and objectifying of Arab migrant women as a result of their ideological representation by the orientalists in the context of diaspora. Faten in Hope and Other Dangerous Pursuits as a Moroccan female migrant in Spain and Reema in The Inheritance of Exile as an American of Arab descent are perceived by the Spanish customer and American boyfriend respectively as harem and sexual objects who can fulfill their fantasies. The agency Lalami and Darraj associate with their female protagonists does however dismantle the fixed representation of orientalism as Faten and Reema are given voice to rewrite the discursive narratives and to present alternative representations of Arab female migrants as being heterogeneous and independent individuals with freedom and control over their choices and decisions. The two studied novels as postcolonial diasporic literature disrupts and debunks the discursive orientalist discourse on Arab women.
Urgensi Literasi Digital bagi Pendidik dalam Meningkatkan Keterampilan Mengelola Pembelajaran
Authors: Warsiyah Warsiyah , Madrah Muna Yastuti , Muflihin Ahmad , Irfan Agus
Published: September 2022

The spread of the Covid-19 virus requires human interaction to be mediated by information and communication technology, including education. Educators must adapt to this change to become role models quickly. However, not all educators can use technology in online learning. For educators in the village who had never used information and communication technology for education, this adaptation process needed guidance in the acceleration, as a necessity of educators with ICT mastery capabilities in the information age and amid the pandemic situation. It takes a mentoring program for educators to improve their ability and competence on digital technology for learning management both luring and online. This program is intended for educators in MI Al-Hikmah Source of Simo Boyolali through a participatory approach. The training began by doing a pretest and continued FGD to map the potential and problems faced by the teacher. Based on the pretest and FGD,  we decided to conduct digital literacy training to improve educator competencies in managing online learning and luring. Penyebaran virus Covid-19 mengharuskan interaksi manusia termediasi oleh teknologi informasi dan komunikasi termasuk dalam bidang pendidikan. Pendidik dituntut untuk beradaptasi dengan cepat terhadap perubahan ini agar tetap mampu menjadi role model. Namun demikian belum semua pendidik mampu memanfaatkan teknologi dalam pembelajaran daring. Bagi pendidik yang berada di desa yang sebelumnya tidak pernah menggunakan teknologi informasi dan komunikasi untuk pembelajaran, bimbingan dalam percepatan proses adaptasi ini perlu dilakukan. Sebagai sebuah keniscayaan pendidik dengan kemampuan penguasaan TIK di era informasi dan ditengah situasi pandemic.  Dibutuhkan program pendampingan bagi pendidik untuk meningkatkan kemampuan dan kompetensi pendidik terhadap pemanfaatan teknologi digital untuk pengelolaan pembelajaran baik luring maupun daring. Program ini ditujukan untuk pendidik di MI Al Hikmah Sumber Simo Boyolali melalui pendekatan partisipatoris. Pelatihan dimulai dengan melakukan pretes dan dilanjutkan FGD untuk memetakan potensi dan masalah yang dihadapai guru. Berdasarkan hasil pretest dan FGD kemudian diputuskan untuk melakukan pelatihan literasi digital untuk meningkatkan kompetensi pendidik dalam mengelola pembelajaran daring dan luringKata kunci: Urgensi; Literasi Digital; Keterampilan; Pendidik; Pembelajaran
Pelatihan Manajemen Keuangan bagi Santri Menuju Kemandirian Pondok Pesantren
Authors: Nurasikin Akhmad , Masyhari Kholid , Imron Ali
Published: September 2022

Finance is one of the resources that directly support the effectiveness and efficiency of Islamic boarding school education management. The independence of Islamic boarding schools is also one of the priority programs of the Ministry of Religious Affairs in 2021. This can be achieved by improving the quality of management/management of Islamic boarding schools, especially professional, effective, efficient, transparent, and accountable financial management. Financial Management Training for Santri towards independence of Islamic Boarding Schools using Participatory Action Research (PAR). That is, all stakeholders actively review current actions to make changes and improvements for the better. The results of community service that have been carried out are that the stages of Islamic boarding school financial management are planning (budgeting), implementation (Accounting), and evaluation (Auditing). Boarding schools of Islamic boarding schools receive assistance in the preparation of the RKAPP (Islamic Boarding School Activity and Budget) or RAPBPP (Islamic Boarding School Revenue and Expenditure Budget Plan) in 2022. It is hoped that the financial management of Islamic Boarding Schools will be more transparent and accountable. The author's suggestion is that it is necessary to improve the RKAPP and evaluation of financial management this year as a reference for the preparation of the RKAPP in the following year. Keuangan/Financial menjadi salah satu sumber daya yang secara langsung mendukung efektifitas dan efisiensi pengelolaan pendidikan pondok pesantren. Kemandirian Pondok pesantren juga menjadi salah satu program prioritas Kementerian Agama tahun 2021. Hal ini dapat dicapai dengan peningkatan kualitas manajemen/pengelolaan pesantren khususnya pengelolaan keuangan yang profesional, efektif, efisien, transparan dan akuntabel. Pelatihan Manajemen Keuangan bagi Santri menuju kemandirian Pondok Pesantren menggunakan Participatory Action Research (PAR). Artinya, semua pihak yang berkepentingan (stakeholders) secara aktif meninjau tindakan saat ini untuk membuat perubahan dan perbaikan ke arah yang lebih baik. Hasil pengabdian masyarakat yang telah dilaksanakan adalah beberapa tahapan manajemen keuangan pondok pesantren yang harus dilaksanakan yakni perencanaan (budgeting), pelaksanaan (Akunting) dan evaluasi (Auditing). Pengurus pondok pesantren mendapat pendampingan penyusunan RKAPP (Rencana Kegiatan dan Anggaran Pondok Pesantren) atau RAPBPP (Rencana Anggaran Penerimaan dan Belanja Pondok Pesantren) tahun 2022. Harapannya pengelolaan keuangan Pondok Pesantren semakin transparan dan akuntabel. Saran penulis, perlu penyempurnaan mengenai RKAPP dan evaluasi pengelolaan keuangan di tahun ini sebagai acuan penyusunan RKAPP di tahun berikutnya.
Penanaman Nilai Demokrasi Pancasila sebagai Upaya Membangun Kesepemahaman dalam Melawan Aksi Teror
Authors: Abdullah Abdullah , Tawakkal George Towar Ikbal
Published: September 2022

Pada perpolitikan internasional, salah satu ancaman keamanan yang menjadi agenda penuntasan bagi banyak pihak adalah kejahatan terorisme. Begitupun di Indonesia, terorisme juga menjadi ancaman. Tidak hanya pada aksi teror yang terjadi, namun juga pada jaringan terorisme yang menyebar di tengah-tengah masyarakat. Keterlibatan pemuda pada jaringan terorisme merupakan satu kondisi yang mengkhawatirkan jika tidak segera ditangani. Hal tersebut yang selanjutnya mengharuskan tenaga pendidik untuk dapat mengatasi dan juga menghindarkan lingkungan pendidikan dari paham-paham terorisme. Menindaklanjuti situasi tersebut, pengabdian ini dilakukan untuk menguatkan nilai-nilai pancasila di kalangan siswa sekolah. Metode yang diterapkan adalah pre-test, presentasi, dan post-test. Hasil kegiatan menunjukkan bahwa terdapat perubahan pemahaman siswa jika dilihat berdasar pretest dan post-test. Siswa yang menjadi peserta presentasi tentang nilai-nilai demokrasi pancasila berdasar pada hasil post-test menunjukkan kemampuan dalam mengidentifikasi radikalisme dan terorisme.In international politics, one of the security threats that are on the agenda for solving many parties is the crime of terrorism. Likewise in Indonesia, terrorism is also a threat. Not only on acts of terror that occur, but also on the network of terrorism that spreads amid society. The involvement of youth in terrorist networks is a worrying condition if it is not immediately addressed. This in turn requires educators to be able to overcome and also avoid the education environment from the notions of terrorism. Following up on the situation, this service is carried out to strengthen Pancasila values among school students. The method applied is a pre-test, presentation, and post-test. The results of the activity showed that there was a change in students' understanding when viewed based on the pre-test and post-test. Students who participated in the presentation on Pancasila democratic values based on the post-test results showed their ability to identify radicalism and terrorism.