bluuebunny/crossref_metadata_2025 huggingface dataset:
Pragmatic Markers in Spoken Discourse
Authors: Eragamreddy Dr. Nagamurali
Published: June 2024

The roles, functions, and effects of pragmatic markers (PMs) in spoken discourse are explored in this study, with a focus on how language learners’ comprehension skills, classification and interpretation abilities, and interactions between verbal and non-verbal PMs are affected. A combination of quantitative and qualitative procedures was employed in this investigation. To evaluate how well PMs in spoken discourse were identified and understood, level 4, English Language Unit, Preparatory Studies Centre fifty participants from the University of Technology and Applied Sciences, Salalah, the Sultanate of Oman completed fifteen quick audio samples with a range of pragmatic characteristics, five additional filler audio segments, and pre-and post-test questionnaires. The study discovered that learners' comprehension of PMs—which regulate discourse structure, convey speaker purpose, and manage conversation flow—improved dramatically with targeted instruction. It emphasized the significance of PMs in the development of communication skills as well as the problems with categorizing PMs due to a lack of a standardized framework.
Trait Correlation and Path Study for Quantitative Traits in Garlic (Allium sativum L.) Genotypes
Authors: Melesse Mulat Getaneh , Asfaw Alemu Abate
Published: June 2024

Garlic is a widely cultivated vegetable with both culinary and medicinal uses in Ethiopia. The analyses, focusing on various traits, help in identifying genotypes with high productivity and quality. Garlic reproduces solely vegetatively due to male and female sterility in its gametophytes. Its domestication originated from the wild species Allium longicuspis Regel. The introduction of diverse garlic varieties contributes to enhancing its genetic potential. This study aimed to assess the relationship between different traits and their influence on garlic bulb yield. The experiment conducted during the rainy season of 2020–2021 at the Fogera National Rice Research and Training Center in Ethiopia. The experiment included 49 garlic genotypes arranged in a simple lattice design with two replications. The results revealed significant genotypic correlation coefficients between fresh bulb yield per hectare and bulb weight per plant (r = 0.82***), pseudo-stem height (r = 0.82***), and clove weight (r = 0.81***). Similarly, significant positive phenotypic associations were observed between fresh bulb yield per hectare and clove weight per bulb (r = 0.77***), pseudo-stem height (r = 0.77***), and bulb weight per plant (r = 0.76***). Further analysis indicated that pseudo-stem height (0.42) and clove weight (0.39) exerted the highest phenotypic direct effects on fresh bulb yield per hectare. Therefore, traits such as clove weight, pseudo-stem height, and bulb weight exhibit high genotypic coefficients and significant direct effects on total bulb yield, making them crucial for direct selection to increase bulb yield.
Genetic Divergence and Cluster Analysis for Bulb Yield and Related Traits in Garlic Genotypes at Fogera, Northwestern, Ethiopia
Authors: Melesse Mulat Getaneh
Published: June 2024

Identifying morphological variations among garlic genotypes is crucial for enhancing garlic breeding schemes. This study aimed to assess genetic diversity based on morphological traits of garlic genotypes. The experiment was conducted at the Fogera National Rice Research and Training Center, utilizing a simple lattice design with two replications for planting the genotypes. A total of 49 Ethiopian garlic genotypes were included in the study. Multivariate analysis methods were employed to assess approximately sixteen morphological characteristics. The genotypes were classified into five distinct clusters based on divergence analysis. Clusters 5 and 4 exhibited the highest inter-cluster distance (29.448), indicating genetic diversity. Conversely, clusters 3 and 1 showed the minimum inter-cluster distance, suggesting genetic similarity. Cluster 5 had the highest mean genotypes, indicating its potential for increasing genetic gain through heterosis breeding. Plant height contributed the most to variance, followed by leaf length, number of cloves per bulb, and total soluble solids. The first two principal components explained 74% of the overall variance. Therefore, this study underscores significant diversity in genotypes based on phenotypic characteristics, which could be valuable for future heterosis breeding programs.
Pediatric Patient with Chronic Hyperplastic Pulpitis: Case Report and Pathology Overview
Authors: Jesus Oliver Renê Viana de , Monteiro Emanuele Souza , Santos Grazielly Andrade Melo dos , Lopes Sabrina Adrielly Santos , Cavalcante Nadyne Andrade , Massena Giovanna Alves Santos , Mene Cecília Bezerra de
Published: June 2024

Pulp polyp (PP) is a type of irreversible pulpitis that occurs more frequently in young teeth, also referred to as chronic hyperplastic pulpitis or proliferative pulpitis, refers to a tissue condition characterized by excessive tissue growth in the pulp chamber. This process is often activated by an open cavity (traditionally induced by caries) and a chronic stimulus. This clinical case aimed to present a surgical traditional approach to extract a tooth diagnosed with a pulp pathology which is classified as a pulp polyp (PP) in a primary first molar. This article has been elaborated following the guidelines for case reports. A 7-year-old pediatric male patient with no systemic complications and no history of dental follow-up was referred to undergo care at the supervised internship clinic at the Maurício de Nassau University Center to assess his oral health condition in the year 2024 and to evaluate multiple caries lesions and sensitivity in some teeth. The patient didn’t show any painful symptoms or signs of secondary infection and did not respond positively to pulp tests. The extraction of unit 74 was performed with minor local anesthesia and atraumatic technique. The removal was successful and the child did not have any complications, the recovery went well, respectively. Pulp polyps can be treated by removing the pulp polyp followed by pulpectomy or root canal therapy, which removes the diseased pulp and seals the canals, or, in extreme situations, by teeth extraction.
In Vitro Antibacterial Activity of Aloe Barbadensis Millar (Aloe Vera) Against Pseudomonas aeruginosa Isolates in Khartoum State, Sudan
Authors: Abdelgader Leila Mohamed A. , Yousif Ekram Abubaker , Eltaib Hadia Abass , Kwami Waseem Sameer , Mahjaf Ghanem Mohammed , Altaher Tibyan Abdalmajed , Saeed Abdelwahab Abdien , Mohamme Mosab Nouraldein
Published: June 2024

Background: It is becoming more widely acknowledged that Pseudomonas aeruginosa (P. aeruginosa) is a significant nosocomial pathogen that can cause serious infections. In general, new therapeutic approaches that prioritize the utilization of extracts and physiologically active chemicals extracted from herbal plants should be used to control P. aeruginosa infections. The World Health Organization (WHO) estimates that in underdeveloped countries, around 80% of the population mostly uses traditional medicine and plant extracts as their primary source of medicine to treat a variety of infectious diseases. Objective: The purpose of this study was to investigate the in vitro antimicrobial activity of A. vera against P. aeruginosa isolated in Khartoum state hospitals. Materials and Methods: The present descriptive study was performed in Khartoum state. Between November 2022 and April 2023, a total of 100 clinical isolates of P. aeruginosa were obtained from patients hospitalized at Khartoum State hospitals. Standard microbiological techniques, such as the Gram stain, catalase test, and oxidase test, were used to identify the isolates. Ciprofloxacin, Ceftriaxone, Meropenem, and Gentamicin. A. vera gel were used in an antimicrobial susceptibility test against the P. aeruginosa strains. Results: Isolates of P. aeruginosa were collected from hospitalized individuals. Of the 100 isolates included in the study, 63 isolates (63%) had been isolated from males and 37 isolates (37%) had been isolated from females. Using the microdilution method, antimicrobial susceptibility testing for 100 P. aeruginosa clinical isolates was conducted for four antibiotics. The results showed that 38% of the isolates were resistant to ciprofloxacin, 94% to ceftriaxone, 82% to gentamicin, and 0% to meropenem. Conclusions: P. aeruginosa demonstrated multidrug resistance to a widely used antibiotic. A different therapeutic agent for the treatment of clinical multi-drug resistance bacteria may be employed in the ethanol extracts of Aloe vera since they have shown antibacterial efficacy against multi-drug resistant P. aeruginosa which is resistant to many drugs and may be treated with a combination of conventional antibacterial discs and the crude extract of Aloe vera. The study's findings validate the traditional wisdom that aloe vera plants may cure microbial infections and suggest that aloe vera may be used to make powerful new antibacterial compounds.
Right Side Chest Stab Wound with Perforation in Diaphragm and Liver Laceration: A Case Report
Authors: Shahraki Ahmad Reza
Published: June 2024

Liver is one of the organs with the highest injury rate, and in recent decades, the guidelines for the treatment of liver trauma have changed considerably. Now, there is a growing consensus that the most important step is diagnosis and depending upon the degree of severity, non-operative therapy is the main treatment method for hepatic trauma if conditions permit. For serious hepatic trauma patients such as those with hemodynamic instability, they should be operated upon as soon as possible. Regardless of the surgical options, doctors should control damage to patients and try to prevent complications. New therapies such as hepatic artery Embolization and liver transplantation. Our case was a 24 years old man with right chest penetrating wound by stab that perforated diaphragm and lacerated liver that both of them was repaired. Management of liver trauma is multidisciplinary. Diaphragmatic injury may be underestimated due to the presence of concomitant lesions of other organs, to a state of shock and respiratory failure, and to the difficulty of identifying diaphragmatic injuries in the absence of high sensitivity and specific diagnostic instruments.
Prevalence of Pregnancy Induced Hypertension in Women Attending Antenatal Clinic in a Tertiary Care Hospital in Maharashtra
Authors: Mishra Dr Nidhi
Published: June 2024

Background- Blood pressure (BP) ≥140/90 mmHg, taken after a period of rest, on two occasions or ≥160/110 mmHg on one occasion in a previously normotensive woman is labeled as pregnancy-induced hypertension. [1,2] Pregnancy-induced hypertension (PIH) is a pregnancy-specific condition that includes gestational hypertension, pre-eclampsia (PE), and eclampsia (E). It is linked to intrauterine death, abruptio placentae, maternal mortality, and intrauterine growth retardation (IUGR) [3, 4]. Aim - to find the prevalence of pregnancy induced hypertension in women attending antenatal clinic in a tertiary care hospital. Materials and methods- Total 200 pregnant women with a gestational age of 20 weeks or greater visiting ANC clinic were included in the study during the period of 5 months (December 2023 to April 2024) at VVP rural hospital, Loni. Demographic details and blood pressure were collected. Data collected was analyzed using Microsoft Excel 2013 and pspp version 1.0.1. Results- Mean age of participant mothers was 23.2 years. Out of total 200 participants, 15 (7.5%) women presented with PIH (8, gestational hypertension and 5, pre-eclampsia and 2, eclampsia). Mean age of pregnant women presenting with PIH was 29 years as compared to the mean age of pregnant women without PIH which was 22 years. Out of 15 participants with PIH, 10 were primigravida, 8 and 3 were from lower and lower middle class respectively. Conclusion- PIH is still important problem and health education and awareness is still needed especially in rural communities.
Risk Factors for Osteoporosis in Chronic Hemodialysis Patients
Authors: Errihani Majdouline , Sobhi Aya , Hassani Kawtar , Benbria Sanaa , Kabbaj Driss El
Published: June 2024

Introduction: in hemodialysis patients. Osteoporosis associated with kidney disease chronic is a complex entity with significant morbidity and mortality relative to risk of fracture. Its prevalence is high, but the incrimination of clinical and biological factors remains poorly identified. The purpose of our study is to determine the prevalence and factors associated with osteoporosis. Methods: A cross-sectional study included 40 chronic hemodialysis patients for at least 6 months. All subjects underwent a bone mineral density (BMD) assay with dual-energy x-rays absorptiometry (DXA) at the lumbar spine (LS) and femoral neck (FN). Data were statistically analyzed by means of descriptive analysis. Patients were divided into 2 groups based on the T-score to define the osteoporotic (t score≤-2.5) and the no-osteoporotic (t score>-2.5). The search for the risk factors studied [age, duration of hemodialysis, parathyroid hormone (PTH), alkaline phosphatases (ALP), and calcification of the abdominal aorta (AAC)] has been carried out by logistic regression. Results: The average age was 59 ± 16 years, 47% were women, and the median of hemodialysis duration was 54 months. The prevalence of osteoporosis at the lumbar spine was 27.5% and at the femoral neck was 32.5%. Regarding risk factors, at the LS, the factors associated with osteoporosis retained in the univariate analysis were age (p=0.034), PTH (p=0.024), AAC (p=0.024), ALP (p=0.027) and in the multivariate analysis, only PTH was significantly associated (p=0.019). At the FN; The factors associated with osteoporosis retained in analysis univariate were age (p = 0.03), AAC (p = 0.01), ALP (p=0.04) and in analysis multivariate was the APL (p= 0.035). Conclusion: Osteoporosis is associated with turnover abnormalities. We suggest that regular screening for fracture risk using DXA and early correction of the disorders.
Cerebral Vascular Accidents Occurring During Type 2 Diabetes in the CHU-PG Internal Medicine Department
Authors: D Camara, B. , Kaly Keïta , O Coulibaly, , K Dao, , Mala Sylla , M Dramé Boubacar , A Coulibaly, , A Sy Djibril, , A Koné, Drago, , I A, Dollo, , O Kamissoko, C. , A Maiga, , M Diakité, , H Guindo, , Sow D. S.
Published: June 2024

Introduction: Diabetes is a major cause of death and disability worldwide. It also represents a significant risk factor for stroke. The excess stroke risk associated with diabetes is significantly higher in women than in men, independent of sex differences observed for other major cardiovascular risk factors. Materials and Method: This retrospective descriptive study was carried out in the Internal Medicine department of Point G University Hospital from January 2008 to December 2012. Included in this work were all type 2 diabetic patients hospitalized in the department during the duration of the study, presenting clinical signs of sentivo-motor deficit with performance of a brain CT scan. Results: At the end of this work, 358 patients were hospitalized, among whom 19 cases of established stroke were recorded, i.e. a frequency of 5.3%. Dilated cardiomyopathy represented 36.8% of cases. LVH and repolarization disorders accounted for 21.1% each. Composite ischemic stroke represented 79% of cases followed by mixed stroke or 16% of cases. The evolution was marked by after-effects such as left hemiparesis 36.8%, right hemiplegia 10.5% and death in 5.3% of cases. Dyslipidemia 82%, hypertension 84.21% were the risk factors most associated with diabetes. Conclusion: Strokes are common in type 2 diabetic patients. Their prevention requires better management of diabetes and its associated risk factors.
Judicial Censorship of the Law's Constitutionality as a Guarantee the Enforcement of the Constitutional Rule
Authors: Karim Hassan Nema
Published: June 2024

Abstract The subject of the research is judicial oversight of the constitutionality of laws as a guarantee of the enforcement of the constitutional rule. We divided it into two sections. The first section dealt with the general framework of judicial oversight of the constitutionality of laws, the nature of judicial oversight, and the emergence of the idea of judicial oversight of the constitutionality of laws.   In the second section, the methods and forms of organizing judicial oversight and its forms were discussed, and methods for initiating judicial oversight of the constitutionality of laws were explained, explaining the differences in state constitutions in introducing judicial oversight Some of them pursued oversight by means of the original law suit for annulment, and some of them took up the defense of unconstitutionality by means of Abstention oversight. The role of the Federal Supreme Court was noted as one of the applications of judicial oversight in Iraq.    The study concluded that establishing the foundations of a legal state based on the rule of law and preserving the rights and freedoms of individuals in it requires establishing guarantees to protect the principle of legality, uphold the constitution, and not deviate from its provisions in form and substance. To achieve this foundation, most countries with democratic systems have followed judicial oversight of the constitutionality of laws to the extent its effectiveness in ensuring respect and supremacy of the Constitution over other legal rules
Sustainable Employability Skills among Bangladeshi University Graduates: Employers' Perspective
Authors: Mohammad Monir Hossan
Published: June 2024

The employability skills of graduates are considered to be essential for ensuring employment in this competitive employment market of 4IR. Through review of the relevant literature and analysis of survey data on employers’ perspective, this study attempts to find the employability skills gap among university graduates. Data was collected from employers through a survey questionnaire and data analysis was carried out through SPSS. Although the evidence shows that there is no specific list of employability skills to be prescribed, the study found some relevant skills like: interpersonal communication skill, problem solving skill, leadership skill, analytical skill, IT skill, critical thinking and creativity skill, decision making skill, adaptability skill, etc. that university graduates lack to get employed. Furthermore, this study attempts to suggest some measures like: modifying the curricula; involving industry experts in teaching-learning; involving students in practical oriented assignments, projects, real case study analysis and solving real life problems in a group; collaborating with industry; introducing employability skills related courses; etc. to be taken by academic institutions to reduce the gap and ensure sustainable employment of university graduates both at home and abroad.
Tautology and Pleonasm in Political Interviews: A Semantic study
Authors:   Al-Mustansiriya University/ College of Political Science, Hussain Karama Hassan
Published: June 2024

Pleonasm refers to the involvement of unnecessary words or morphemes represents pleonastic words which repeat a mentioned information elsewhere, whereas tautology refers to the inacceptable repetition of the same ideas, words, or phrases by using diverse words. In English, there is a perplexity to distinguish some elements that may be misled to be regarded as pleonastic or tautological. The current study aims at analysing two political interviews in the light of pleonasm and tautology concepts and find out the differences between them semantically. The data analysis is taken from two presidential interviews for the American presidents Trump and Biden in 2020. The study has concluded that tautology and pleonasm can be used in disparate degrees in political speeches. Using tautology is more necessary than pleonasm in political speeches, in which pleonasm concentrates on ideas and implied meaning, which can be misled to simple, ordinary people, while tautology is clear and can be understood by any simple brain in spite that it is dull and boring sometimes if the repetition is exaggerated, but can be perceived easily to focus on some important ideas the politician sees it is significant.
A Phono-stylistic Analysis of Utterance Stress in Steve Harvey's talk show
Authors:   University of Baghdad, College of Arts, Department of English, Baghdad, Iraq, Abdulkareem Buraak , al-Saidi Abdali H. ,   University of Baghdad, College of Arts, Department of English, Baghdad, Iraq
Published: June 2024

patterns of utterance stress in discourse direct attention to specific themes and reactions, controlling the flow and coherence of conversation. this study examines the utterance stress in Steve Harvey's selected episodes from a phono-stylistic perspective. this study is hoped to improve understanding of linguistic mechanism in talk show communication, highlighting the importance of phonetic features in transmitting meaning and increasing broadcast conversation participation. the researcher concentrates on the types of focus functions of utterance stress of some episodes available on YouTube. to conduct the analysis, the researcher adopts (Carr, 2013; Davenport& Hannahs 2005) to analyze utterance stress and Leech and Short (2007) to examine the stylistic features of the data selected. based on the adopted model, the study concludes: the study utilizes utterance stress, focus and content. while stylistic features include syntax, vocabulary, narrative viewpoint, politeness, impoliteness and cultural references.
QUALITY WORK LIFE AND TEACHERS’ DEDICATION OF PUBLIC ELEMENTARY SCHOOLS
Authors: Sheryl May V. Manlupig
Published: June 2024

The study aimed to determine the extent of quality work life and the level of teachers’ dedication of public elementary schools. This study employed a non-experimental quantitative research design utilizing descriptive-correlation method. Validated questionnaire and Universal sampling procedure were utilized considering the minimal number of teachers in the research locale. One hundred twenty (120) public elementary school teachers were the respondents of the study. Using mean, Pearson-r, and regression analysis, the findings revealed that the quality of work life was extensive while the extent of teachers’ dedication of public elementary schools was also extensive. Moreover, the overall results disclosed that indicators for the quality of work life were positively correlated to the teachers’ dedication of public elementary schools. Further, results from the regression analysis revealed the following have a strong influence of quality work life on the teachers’ dedication of public elementary schools: job characteristics, compensation, and working conditions. It is recommended that the Department of Education should allocate sufficient funds to guarantee that schools have access to the infrastructure, technology, and teaching materials required to support efficient teaching and learning. For teachers to manage stress and maintain a healthy work-life balance, it also offers support services like counselling, mental health support, and wellness programs.
KEYWORDS: Quality work life, teachers’ dedication
Efektivitas Financial Leverage Sebagai Akibat Dari Kinerja Keuangan Rentan Dengan Pandemi Pada Bank Konvensional di Indonesia
Authors: Amalina Nur , Prakoso Sajiwo Tri , Insani Kharisma Aulia
Published: June 2024

This study aims to examine the effect of leverage on financial performance. The data used in this study is secondary data from the financial reports of banking companies listed on the Indonesia Stock Exchange as of August 2019 -2021. In taking the sampling using purposive sampling technique. The analytical method used in this study is multiple regression analysis. The results of the study show that the Debt ratio and Debt to equity ratio have an effect on Return On Assets. Meanwhile, the Interest Covaregae Ratio has no effect on Return On Assets. For Debt to equity ratio and Interest Covaregae Ratio affect Return On Equity. Meanwhile, the Debt ratio has no effect on Return On Equity.
Pengaruh Kepatuhan, Kecenderungan Negosiasi, Moral Pajak dan Manajemen Laba terhadap Voluntary Tax Compliance di Mediasi Persepsi Kebijakan Fiskal
Authors: Yuniati Tri
Published: June 2024

The purpose of this study was to analyze how the influence of taxpayer compliance, negotiation tendencies, tax morale and earnings management on valuntary tax compliance. and how the influence of taxpayer compliance, negotiation tendencies, tax morale and earnings management on valuntary tax compliance is mediated by fiscal policy. The study population is a taxpayer of Small and Medium Enterprises domiciled in in Kenjeran, East Java, the study sample involved 60 respondents using a purposive sampling method, the questionnaire as an instrument and processed using SEM Warp PLS 6.0 approach. The results showed that taxpayer compliance, the desire to negotiate, earnings management has a positive impact on valuntary tax compliance, but moral tax has a negative impact on valuntary tax compliance, taxpayer compliance, the desire to negotiate earnings management in fiscal policy mediation has a positive impact on valuntary tax compliance while tax morale in the mediation of fiscal policy has a negative impact on valuntary tax compliance. The novelty was found that taxpayers are obedient in carrying out their tax obligations influenced by the behavior of taxpayers, not because of regulations, behavior seen from economic, financial conditions by using a fiscal policy approach and conceptual approach based on a developing view of the tax policy.
Exclusion of Universities from EU Funds Hurts Young Researchers – Research Report
Authors: Koltai Júlia , Wilhelm Imola , Kecskés Gábor , Hatvani István Gábor , Lipták Katalin , Lencsés Ákos , Kemenesi Gábor , Lengyel Balázs
Published: June 2024

In 2022, citing the erosion of transparency and academic freedom in Hungary, the Council of the European Union suspended research related EU funding and exchange programmes to Hungarian universities run by newly established public interest trusts. There has been unceasing debate between the EU and Hungary since then, while the recent initial hearings of the universities’ appeals in the Court of Justice of the European Union suggest that lasting suspension will be the outcome. Here we summarize a comprehensive survey that reveals a troubling landscape for the Hungarian academic and research communities as a consequence of the ban. Particularly alarming is the pronounced impact on early career researchers, not just from institutions directly affected by the suspension but, strikingly, from those still eligible for funding. The findings of the survey underscore a pervasive uncertainty among non-Hungarian EU consortia leaders about whether to engage with Hungarian universities and research institutes at all. This climate of doubt may well result in detrimental effects on the international stature of Hungarian research, hinting at long-lasting impediments to the country's scientific competitiveness on the European stage.
Application and research progress of CAR-T cell therapy in autoimmune diseases
Authors: Yu Xiaoxiao , Shang Haodong , Shen Xinru , Zhang Jing , Chang Ting , Ruan Zhe , Jia Yongliang , Gao Feng
Published: June 2024

The conventional clinical therapies for autoimmune diseases (ADs) lack specificity, necessitating long-term medication that can lead to serious side effects. In contrast, chimeric antigen receptor (CAR) T cell therapy for ADs, characterized by fewer side effects and longer-lasting therapeutic effects, represents a new direction for the specific treatment of ADs. T cells modified with CAR genes possess the ability to not only secrete perforin, granzymes, and other molecules that target autoreactive immune cells but also to lead effector and regulatory T cells into autoimmune environments, thereby exerting transport, proliferation, and immune regulatory functions. Chimeric autoantibody receptor T cells can recognize and kill autoreactive cells expressing target autoantibodies through their specific antigens. In this article, we comprehensively expound on the application of CAR-T cell therapy in different ADs and summarize the current research progress in this regard. This review aims to enhance the application of CAR-T therapy in AD treatment and facilitate further studies aimed at addressing the existing gaps in CAR-T therapy for ADs.
Deciphering novel molecular gene expression signatures and pathways in cystic fibrosis through integrative bioinformatics strategies
Authors: Mia Mamun , Rahman Oany Arafat , Pervin Tahmina , Sharmin Duza Syeda
Published: June 2024

Cystic fibrosis (CF), a fatal autosomal recessive disorder, is triggered by a genetic alteration of the CF transmembrane conductance regulator (CFTR) gene. On a global scale, around one in 3000 live births are affected with CF annually. While diagnosis and therapy are available for CF patients with non-specific and rare mutations, the current research is dedicated to exploring customized biomarkers, genes, signaling networks, and therapy for improving the management of CF. Although still in the early stages of development and validation, mRNA and gene-based treatment strategies are aimed to target patients who are resistant to CFTR gene restoration therapies. In this study, we utilized the systems biology approaches integrated with gene expression analysis to identify novel biomarkers and pathways for CF treatment. At first, out of 54,676 differentially expressed genes, we identified 104 upregulated and 107 downregulated genes. The upregulated genes were largely concentrated on Glutamatergic synapses, and the downregulated genes were enriched in ubiquitin-mediated proteolysis. Utilizing the enrichment analysis, we explored deeper into the pathways linked to these genes, with emphasis on relevant pathways involving bronchial epithelial cells. Following the enrichment analysis, we identified six essential genes: WWP2, RNASEL, CUL1, CDC42, HDAC4, and UBA2. Furthermore, the discovered genes were evaluated using expression profile analysis. Finally, our data indicate that the WWP2 gene has a critical role in CF management. The current findings provide a coherent theoretical foundation for future experiments to further explore the WWP2 gene as a unique and prognostic target for developing an effective CF therapeutic approach.
The potential therapeutic value of terpenes
Authors: Lowe Henry , Ali Amza , Steele Blair , Gordon Lorenzo , Grant Justin
Published: June 2024

Terpenes form part of a huge and diverse class of naturally occurring and volatile secondary metabolites produced by many plants, fruits, animals, insects, and other organisms. They are the largest group of naturally occurring metabolites, with over 55,000 types of terpenes produced by plants alone, primarily as essential oils. In humans, they contain significant biological properties such as antifungal, antiviral, antimicrobial, anti-inflammatory, antiparasitic, antihyperglycemic, anti-cancer, and analgesic agents. In plants, terpenes also play significant roles in defensive mechanisms against herbivores and invasive plants, disease resistance, chemical signaling and communication between plants, protection against photo-oxidation, plant-environment mediation, thermo-protection, and the attraction of pollinators. In addition, terpenes are responsible for a plant’s scent, taste, flavor, and pigmentation, leading to their commercial use as fragrances and food dyes. Terpenes are also used in the production of synthetic polymers, natural rubbers (polyisoprene), organic solvents, varnishes, inks, adhesives, cleaning products, biofuels, pesticides, and food and drink products. For these reasons, terpenes have significant value in modern medicine, pharmacy, nutraceuticals, cosmetics, and other industries.
Study of the Role of Ultra-Processed Food (UPF) on the Risk of Obesity in Adolescents: An Observational Study in the Adolescent Community in Jambi City, Indonesia
Authors: Heri Yanto Putra  , Santoso Alexander Halim
Published: June 2024

Obesity in adolescents is an increasingly worrying global health problem. Unhealthy eating patterns, especially consumption of ultra-processed foods (UPF), are thought to be one of the main risk factors. This study aims to examine the relationship between UPF consumption and the risk of obesity in adolescents in Jambi City, Indonesia. Cross-sectional observational research was conducted on 350 adolescents aged 13-18 years in Jambi City. UPF consumption data was collected using the NOVA questionnaire, while anthropometric data (height, weight) was measured directly. Logistic regression analysis was used to examine the relationship between UPF consumption and the risk of obesity, with adjustment for potential confounding variables such as gender, age, and socio-economic status. The results showed that high UPF consumption (above the median 4.2 servings/day) significantly increased the risk of obesity in adolescents in Jambi City (OR = 2.87; 95% CI: 1.65-4.98; p < 0.001). This relationship remained significant after adjusting for confounding variables. No significant relationship was found between gender, age, and socioeconomic status with the risk of obesity. High UPF consumption is an independent risk factor for the incidence of obesity in adolescents in Jambi City. Comprehensive public health interventions are needed to reduce UPF consumption and promote healthy eating patterns in adolescents.
Application of Division Counting Machine Media for Deaf Students in Division Operation Material
Authors: Romadona Desi Amalia , Lutfiyah Lutfiyah , Panglipur Indah Rahayu
Published: June 2024

Media is an effective tool used by teachers to support learning to convey the content of teaching materials. This study aims to determine the application of “division calculation machine” media for deaf students in division operation material. This research uses a descriptive approach with qualitative research. The data sources used are test questions, observation, interviews, and documentation. This research was conducted at SLB ABC Balung with the research subjects as many as 3 high school deaf students. The results of this study by applying the division calculation machine media used to solve division problems can help deaf students to understand the division operation material. Counting using the media “Division Counting Machine” can make it easier for students to count and make counting faster than counting manually although there is 1 student who says it is faster to use the manual than using the media but the student prefers to use the media because there is no need to count and only move the ice cream sticks. Based on this research, the media can make it easier for students to learn division and the media as a facilitator in the learning process in class.
EVALUASI TINGKAT KINERJA KONTRAKTOR DENGAN METODE INDEKS
Authors: Fatimah Aldina , Purnanda Sabar
Published: June 2024

Kerja sama yang baik antara owner dan kontraktor dapat mempengaruhi kelancaran pada suatu proyek konstruksi. Salah satu tolak ukur untuk mencapai dalam keberhasilan kerja sama tersebut tingkat kinerja kontraktor. Permasalahan dalam penelitian ini adalah faktor-faktor apa saja yang mempengaruhi kinerja kontraktor, faktor dominan yang mempengaruhi kinerja kontraktor, dan mengevaluasi tingkat kinerja kontraktor. Tujuan penelitian ini adalah untuk mengetahui faktorfaktor apa saja yang mempengaruhi kinerja kontraktor, untuk mengetahui faktor dominan yang mempengaruhi kinerja kontraktor, dan untuk mengevaluasi tingkat kinerja kontraktor pada proyek pembangunan gedung kantor Ditlantas Polda Aceh menggunakan metode indeks. Pengumpulan data primer dilakukan dengan menyebarkan kuesioner kepada owner, pejabat pemeriksa pekerjaan, pejabat penerima pekerjaan, pejabat pengawas pekerjaan, konsultan perencana, dan konsultan pengawas, dengan jumlah 12 responden menggunakan teknik sampling kuota. Metode yang digunakan adalah metode Customer Satisfaction Index. Hasil uji validitas yaitu diperoleh nilai ratarata dari setiap variabel lebih besar dari nilai Rtabel dan nilai Rtabel 0,5760 uji dengan taraf signifikan 5%. Hal ini menunjukkan bahwa variabel yang digunakan adalah valid. Selanjutnya hasil uji reliabilitas pada setiap variabel rata-rata yaitu 0,978 lebih besar dari nilai Cronbach Alpha yaitu lebih besar dari 0,6. Hal ini juga menunjukkan bahwa responden konsisten dalam menjawab pertanyaan (reliabel). Selanjutnya analisis deskriptif hasil dilakukan terhadap variabel performance (X1), time (X2), accessability dan responsiveness (X3), accuracy (X4), realiability (X5), communication (X6), dan competence (X7). Hasil analisis deskriptif terdapat nilai mean tertinggi 4,11 menunjukkan puas pada faktor komunikasi, dan nilai mean terendah 3,50 menunjukkan puas pada faktor waktu. Nilai Customer Satisfaction Index sebesar 78,00% yang berarti pihak penyedia jasa merasa puas terhadap kinerja kontraktor. Maka secara keseluruhan dari hasil evaluasi dapat disimpulkan bahwa owner merasa puas terhadap kinerja kontraktor pada proyek pembangunan gedung kantor Ditlantas Polda Aceh.
Pengaruh Proporsi Kendaraan Terhadap Kecepatan Arus Lalu Lintas
Authors: Hidayat Rifki , Shafira Niskhi Aulya
Published: June 2024

Transportation is the movement of people or goods from one place to another using a vehicle driven by humans or machines. Along with its development, the number of vehicles in Banda Aceh is increasing. On the Tgk Chik Ditiro road, traffic jams often occur, because there are schools, offices, many traders who trade on the shoulder of the road and the sidewalk, there are several vehicles against the flow, and vehicles parked carelessly, there are delays or movement of traffic flow especially at the hour busy. Based on observations in the field, traffic flow at busy times is dominated by two wheels and four wheels, so that it affects the speed on the Tgk Chik Ditiro road in Banda Aceh City. The purpose of this research is to find out what percentage of the effect of the proportion of vehicles on road traffic flow and to get the value of the proportion of vehicles on the road. The results obtained for the highest traffic volume were obtained on Thursday 26 September 2019 at 17.00-18.00 amounting to 6669.60 pcu / hour, the value of road capacity was 4938 pcu / hour, while the level of road service with the degree of saturation obtained was 1.35 means the Jalan Tgk. Chik Ditiro Kota Banda Aceh is included in category F, where the flow is blocked, the speed is low, the volume is above capacity, and there is a delay. The results of traffic volume for 3 (three) days obtained the maximum proportion of two-wheeled vehicles on Thursday 26 September 2019 at 08.00-09.00 WIB with a value of 48.43%. For the Maximum Proportion of four-wheeled vehicles (LV) on Thursday 26 September 2019 at 17.00-18.00 WIB with a value of 74.77%. In the research, it can be seen that the dominant light vehicle growth affects these roads.
PUSAT REHABILITASI NARKOBA ACEH DI JANTHO
Authors: Putri Puspa Sari  , Effendi Nurzal
Published: June 2024

Aceh merupakan daerah peringkat pertama pengedar dan pengguna narkotika jenis ganja. Dari 73.201 pecandu, 916 telah direhabilitasi, dimana 12% dari jumlah tersebut direhabilitasi di Kota Banda Aceh pada 2 (dua) tempat yang berbeda dan hanya menampung pasien narkoba pria. Tujuan perancangan ini adalah merancang sebuah bangunan yang menampung pasien narkoba pria dan wanita berskala provinsi sehingga dapat membantu penyembuhan dan pemulihan pecandu Narkotika, Psikotropika, dan Zat Adiktif lainnya (NAPZA) dengan pelayanan medis dan pelayanan sosial. Lokasi rancangan berada di Jln. Prof. A. Majid Ibrahim, Barueh, Kota Jantho, Kabupaten Aceh Besar, Provinsi Aceh. Klasifikasi Pusat Rehabilitasi Narkoba Aceh di Jantho termasuk dalam kategori rehabilitatif (pemulihan). Berdasarkan fungsinya yang mempertimbangkan kenyamanan pemakai maka pendekatan tema rancangan adalah tema arsitektur organik. Analisis yang digunakan adalah analisis fungsional, analisis lingkungan dan analisis bangunan. Hasil rancangan organik yang diterapkan perancangan ini adalah building as nature, of the people dan of the hill dimana implementasi mampu menyelaraskan bangunan dengan alam, memanfaatkan kondisi lingkungan yang alami, mempertimbangkan kenyamanan pemakai bangunan dan memberikan ide dan solusi rancangan yang unik pada lokasi yang memiliki kontur tanah yang tidak stabil. Pusat Rehabilitasi Narkoba Aceh ini dirancang bermassa banyak yang terdiri dari 5 massa dengan daya tampung 500 pasien. Luas Lahan 31.250 m², Koefisien Dasar Bangunan 40% yaitu 12.000 m² dan Koefisien Lantai Bangunan 3,5 yaitu 42.000 m². Fasilitas yang direncanakan adalah Kantor Administrasi dan Instalasi Gawat Darurat (IGD), Unit Asrama Pasien (Putra dan Putri), Unit Terapi, Unit Pemantapan Sosial, Fasilitas Penunjang dan Parkir.
IDENTIFIKASI PENERAPAN KESELAMATAN DAN KESEHATAN KERJA PADA PELAKSANAAN PROYEK FLY OVER SIMPANG SURABAYA KOTA BANDA ACEH
Authors: Amin Jurisman , Syammaun Tamalkhani , Gunawan Riqi
Published: June 2024

Kasus kecelakaan kerja kerap terulang akibat dari permasalahan K3 yang kompleks di Indonesia. Mengingat proyek fly over merupakan salah satu mega proyek di Kota Banda Aceh, maka memiliki resiko kecelakaan kerja yang cukup tinggi, sehingga K3 sangat penting untuk diterapkan. Dengan adanya penerapan K3 pada proyek, maka semua tenaga kerja akan mendapatkan jaminan atas keselamatan dan kesehatan kerja, sehingga tenaga kerja akan lebih giat dan disiplin dalam melaksanakan tugasnya, serta tidak akan terbeban dengan resiko yang akan timbul dalam proyek konstruksi. Penelitian ini bertujuan untuk mengidentifikasi minat tim pelaksanaan kegiatan dalam penerapan K3 pada proyek fly over Simpang Surabaya Kota Banda Aceh, serta mengidentifikasi penerapan K3 yang dominan pada pelaksanaan proyek tersebut. Pengamatan dilakukan pada tim pelaksanaan konstruksi (stakeholder) pada proyek fly over Kota Banda Aceh, yaitu owner, konsultan supervisi, dan pelaksana. Identifikasi yang dilakukan pada perlengkapan Alat Pelindung Diri (APD), perlengkapan Alat Pengaman Kerja (APK), perlengkapan kesehatan di proyek, lingkungan kerja, dan program umum. Analisa statistika yang digunakan adalah uji reliabilitas, uji validitas dan analisis deskriptif, melalui program Statistical Product and Service Solution (SPSS) versi 22. Hasil penelitian menunjukkan bahwa penerapan K3 dalam pelaksanaan proyek fly over, yang diminati oleh stakeholder adalah program perlengkapan APD dengan mean 4,609, perlengkapan APK dengan mean 4,600, lingkungan kerja dengan mean 4,559, umum dengan mean 4,585, dan perlengkapan kesehatan di proyek dengan mean 4,423. Penerapan K3 yang paling dominan diminati pada pelaksanaan proyek fly over adalah program perlengkapan APD dengan mean 4,609. Program perlengkapan APD pada proyek fly over sudah diimplementasikan sepenuhnya oleh pelaksana. Dalam hal ini stakeholder yang menjalankan tugasnya pada proyek fly over, sadar akan penggunaan APD dan menunjukkan minat yang besar dalam penerapannya.
OPTIMALISASI WAKTU DAN BIAYA DENGAN METODE PRECEDENCE DIAGRAM METHOD
Authors: Syammaun Tamalkhani , A. Rani Hafnidar , Rahmat Fadhil
Published: June 2024

Waktu dan biaya sangat berpengaruh terhadap keberhasilan dan kegagalan suatu proyek. Tolak ukur keberhasilan proyek biasanya dilihat dari waktu penyelesaian yang singkat dengan biaya yang minimal tanpa meninggalkan mutu hasil pekerjaan. Oleh karena itu, salah satu usaha untuk mengoptimalisasi waktu dan biaya adalah dengan menggunakan metode Precedence Diagram Method (PDM). Pembangunan Gedung Fakultas Ilmu Politik dan Ilmu Sosial Universitas Syiah Kuala ini dibangun III (tiga) lantai dengan anggaran proyek adalah sebesar Rp. 3.607.020.000,00 (Tiga Milyar Enam Ratus Tujuh Juta Dua Puluh Ribu Rupiah) dengan waktu pelaksanaan selama 10 bulan sesuai dengan time schedule dan kurva-S. Permasalahan dalam penelitian ini adalah membandingkan waktu dan biaya antara perencanaan (time schedule dan kurva-S) dengan metode PDM. Tujuan penelitian ini adalah untuk mengetahui durasi (waktu) optimum, mengetahui biaya yang diperlukan untuk pelaksanaan proyek serta membandingkan waktu dan biaya proyek antara perencanaan (time schedule dan kurva-S) dengan metode PDM. Metode penelitian dalam perencanaan ini dimulai dengan pengumpulan data berupa data sekunder, untuk analisa dan pengolahan data secara manual dimulai dengan perhitungan PDM kemudian dilanjutkan dengan perhitungan float dan jalur kritis. Hasil perhitungan waktu dengan metode PDM diperoleh waktu penyelesaian proyek selama 232 hari lebih cepat 23 hari dari metode kurva-S. Hasil perhitungan biaya secara total dengan menggunakan metode PDM diperoleh biaya sebesar Rp.3.226.282.572 lebih murah dibandingkan dengan menggunakan metode kurva-S dengan selisih biaya Rp.52.829.994,6. Hasil Perhitungan float dan jalur kritis pada penelitian ini dengan metode PDM memperlihatkan bahwa semua kegiatan tidak terdapat float dan semuanya jalur kritis dibandingkan dengan metode kurva-S terdapat float dan tidak semuanya jalur kritis pada semua kegiatan. Dengan demikian, metode PDM dapat mengoptimalkan waktu dan biaya.
DAMPAK PEMBANGUNAN JALAN TOL BANDA ACEH-SIGLI TERHADAP LINGKUNGAN
Authors: A. Rani Hafnidar , Azlan Muammar
Published: June 2024

Penyelenggaraan jalan tol dimaksudkan untuk mewujudkan pemerataan pembangunan dan hasil–hasilnya serta keseimbangan dalam pengembangan wilayah dengan memperhatikan keadilan, yang dapat dicapai dengan membina jaringan jalan yang dananya berasal dari pengguna jalan. Pengadaan tanah jalan tol sekitar 853 hektare tanah yang akan digunakan untuk ruas jalan tol Banda Aceh - Sigli sepanjang 74 km dan seluas 210 hektar berada di kawasan Hutan Produksi maupun Hutan Produksi Konversi. Penelitian ini bertujuan untuk mengkaji apakah pembangunan jalan tol Banda Aceh - Sigli berdampak terhadap lingkungan, serta untuk mengetahui kesesuaian penanganan lingkungan menurut Peraturan Menteri Lingkungan Hidup nomor 16 tahun 2012. Teknik pengumpulan data menggunakan kuesioner, yang diberikan kepada 96 responden utuk mempertanyakan dampak lingkungan pada pembangunan jalan tol serta 25 responden menanyakan tentang penanganan lingkungan kepada pejabat antara lain Camat Blang Bintang, Keucik di tiga Desa, Manajer Proyek dan Karyawan Adhi Karya. Metode statistika yang digunakan adalah uji validitas, uji reliabilitas dan analisis deskriptif. Hasil uji validitas untuk faktor dampak lingkungan, menunjukkan hasil nilai r hitung (0,372) > r tabel (0,206) dengan signifikansi (5%), sedangkan hasil uji validitas untuk faktor penanganan lingkungan diperoleh nilai r hitung (0,507) > r tabel (0,413) dengan signifikansi (5%). Hasil uji reliabilitas menunjukkan bahwa faktor dampak lingkungan dengan nilai Cronbach Alpha (0,660) > 0,6 dan faktor penanganan lingkungan dengan nilai Cronbach Alpha (0,609) > 0,6. Dengan demikian instrumen penelitian yang digunakan adalah valid dan reliabel. Hasil analisis dekriptif menunjukkan bahwa pembangunan jalan tol Banda Aceh - Sigli berdampak terhadap lingkungan dan penanganan lingkungan yang dilaksanakan pada pembanguan jalan tol telah sesuai menurut Peraturan Menteri Lingkungan Hidup nomor 12 tahun 2012.