bluuebunny/crossref_metadata_2025 huggingface dataset:
Severe postoperative hyperbilirubinemia in congenital heart disease
Authors: Chen Xiaolan , Bai Ming , Sun Shiren , Chen Xiangmei
Published: August 2021

Purpose

The purpose of our present study was to explore the characteristics and outcomes of congenital heart disease (CHD) patients with severe postoperative hyperbilirubinemia.

Methods

All patients who underwent cardiopulmonary bypass surgical treatment for CHD and had severe postoperative hyperbilirubinemia (total bilirubin [TB] ≥85.5 μmol/L) in our center between January 2015 and December 2018 were retrospectively screened. Univariate and multivariate analyses were employed to identify risk factors for the study endpoints, including postoperative acute kidney injury (AKI), in-hospital mortality, and long-term mortality.

Results

After screening, 86 patients were included in our present study. In-hospital mortality was 10.9%. Fifty-one (59.3%) patients experienced AKI, and four (4.7%) patients received continuous renal replacement therapy. Multivariate analysis identified that the peak TB concentration (P = 0.002) and duration of mechanical ventilation (P = 0.008) were independent risk factors for in-hospital mortality, and stage 3 AKI was an independent risk factor for long-term mortality. The optimal cutoff value for peak TB concentration was 125.9 μmol/L. Patients with a postoperative TB level ≥125.9 μmol/L had worse long-term survival.

Conclusion

Hyperbilirubinemia was a common complication after CHD surgery. CHD patients with severe postoperative hyperbilirubinemia ≥125.9 μmol/L and AKI had a higher risk of mortality.
Preparation and characterization of tung oil-rosin-based polyester internal sizing agent
Authors: Xu Yazhou , Dai Songlin , Bi Liangwu , Chen Yuxiang
Published: August 2021

A series of tung oil-rosin-based polyester (TRP) used as internal sizing agents were prepared using rosin, tung oil, maleic anhydride, and glycerol. TRP structure and properties were examined using Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC) and gel permeation chromatography (GPC). The TRP latexes were subsequently used as internal sizing agents, and the sizing properties were evaluated using a scanning electron microscope (SEM), a video-based dynamic contact angle measuring device and a Cobb absorbency tester. The optimal conditions for preparing the TRP sizing agent were as follows: the hydroxy-carboxyl ratio of the material was 0.25; the maleic anhydride dosage was 20 % of rosin; and the tung oil dosage was 40 % of rosin. Under the best conditions, the sized paper Cobb-60 was 15.6 

g
/

m

2

\text{g}/{\text{m}^{2}}

, the tensile index was 45.1 N·m/g, the burst index was 3.1 kPa·

m

2

{\text{m}^{2}}

/g, and the tear index was 15.6 mN·

m

2

{\text{m}^{2}}

/g.
Exodus als pädagogisches Narrativ
Authors: Koerrenz Ralf
Published: August 2021

Vor dem Hintergrund der typologischen Unterscheidung eines historischen und eines systematischen Erkenntnisinteresses, wird die Exodus-Überlieferung als ein pädagogisches Narrativ in den Blick genommen. Darin wird die Exodus-Überlieferung auf eine implizite Pädagogik hin rekonstruiert. In dieser Pädagogik wird das Narrativ kollektiv als Erziehung (z. B. über das Pessach-Fest) und individuell als Bildung (z. B. über das Sh*ma Israel) inszeniert. Die pädagogische Wirkungsmacht der Exodus-Überlieferung wird vor allem im Anschluss an Michael Walzers Untersuchung „Exodus und Revolution“ entfaltet.
WHY HOSPITAL WASTE MANAGEMENT IS IMPORTANT TO THE ENVIRONMENT?: A SYSTEMATIC LITERATURE REVIEW
Authors: Deraman Suriati , Loon Lee Khai , Muhamad Tamyez Puteri Fadzline
Published: August 2021

Today, the healthcare industry has grown in importance as the number of hospitals has increased in response to the increased number of patients. This signifies that the world will be facing a more critical environment as a result of waste generation by hospitals. However, there are still insufficient studies that systematically review the existing literature on hospital waste management. Thus, this systematic literature review focuses on hospital waste management and its environmental impact. The results from Google Scholar and Science Direct show 80 articles starting from 2015 to 2020. Only 12 articles fulfil the criteria for further analysis. Most studies indicated the presence of hospital waste procedures such as waste segregation, a lack of awareness among clinical staff, poor facilities and government enforcement. The study contributes to the body of knowledge and the industry. This study explains the importance and environmental impact of hospital waste management.  A recommendation for future research is provided.
Correlation Between Arm Muscle Power and Badminton Smash Skill
Authors: Akbari Myrza , Mistar Johaidah , Ismail Rahmati , Ismail Razali
Published: August 2021

Based on theoretical studies, the variable arm muscle power is an important factor of physical condition in supporting badminton smash skills. This study aims to determine the correlation between arm muscle power and badminton smash skills. This research uses a quantitative approach with correlational research type. The research sample consisted of 73 people who were selected from physical Serambi Mekkah University, Banda Aceh. The research instruments used for each varibale were: arm muscle power using the shot put test instrument, while for badminton smash skills using a process and result test developed by the author himself, the data analysis stages consisted of calculating the mean, standard deviation.. The stages of data analysis carried out were the calculation of the average, standard deviation, determination of the t score, calculation of the correlation and the t test to determine the significance of the correlation between variables. Based on the analysis of research data, The correlation between arm muscle power and badminton smash skills is (r = 0.88. which means that there is a significant correlation between arm muscle power and badminton smash skills. Based on the calculation of the coefficient of determination, it was also found that arm muscle power contributed 78.68% to badminton smash skills.
Indonesian Version of the Healthy Lifestyle Beliefs Scale for College Student: A Psychometric Study
Authors: Sofyan Davi , Saputra Yudha Munajat , Nurihsan Juntikan , Kusmaedi Nurlan
Published: August 2021

The purpose of this study was to measure the healthy lifestyle beliefs by evaluating the validity and reliability of the healthy lifestyle belief scale in physical education students at Universitas Majalengka, West Java, Indonesia. The method used in the research is quantitative method with descriptive research type which was conducted on 106 physical education students from November 2020 to December 2020. Data collection was carried out using a google form which contains socio-demographic information and a healthy lifestyle belief scale. Cronbachâ€™s Alpha and total item score analysis were used in the data analysis. Use Cronbachâ€™s alpha to determine internal consistency of healthy lifestyle belief scales. The results showed that Cronbachâ€™s alpha value was 0.968 and 16 items from the healthy lifestyle belief scale were normally distributed. The analysis showed 53% of the total variance. The healthy lifestyle belief scale for physical education students is a valid and reliable measurement tool and can be used as an instrument to develop relevant program interventions through physical education in schools and colleges.
The Anthropometric Profiles and Physical Fitness for Elementary School Children
Authors: Arisyandi Edo , Hartati Hartati , Destriana Destriana , Pranata Doni
Published: August 2021

The aim of this study was to determine the anthropometric profile data and physical fitness of elementary school children aged 10-12 years 11 Tanjung Batu public elementary school 2020-2021. The method used in this research is quantitative descriptive method by measuring and testing TKJI 2010, the total sample is 25 students. The results of the research obtained on the anthropometric profile to see the body mass index obtained the nutritional status of 18 underweight students, 7 normal people, on the physical fitness test, 5 people were in good category, 16 people were enough, and 4 people were enough, and there was a relationship between anthropometric profiles. with students' physical fitness. After the data has been obtained, the teachers at the 11 Tanjung Batu public elementrary school can review and make a reference in the upcoming learning process, so that anthropometric data and the level of studentâ€™s physical fitness can improve from before and will be even better.
ÇOCUKLAR VE EBEVEYNLER MOLAR İNSİZÖR HİPOMİNERALİZASYONU AĞIZ SAĞLIĞI SORUNU OLARAK ALGILIYOR MU?
Authors: İLİSULU Ceren , YENİDÜNYA Deniz , KORUYUCU Mine , ÖZCAN Hazal , KASIMOĞLU Yelda , SEYMEN Figen
Published: August 2021

Amaç: Bu çalışma MIH gözlenen çocuklarda ve ebeveynlerinde; dişlerinin sağlık durumu, tedavi gereksinimi, dişlerin görünüşünden dolayı oluşan memnuniyetsizlik, endişe gibi etkilerinin belirlenerek hayat kalitelerinin gözlenmesi, MIH’ın fiziksel ve psikolojik etkilerinin ebeveyn ve çocuklar üzerinde yarattığı algılardaki farklılıkların tespit edilmesi amaçlanmıştır.
Gereç ve Yöntem: Bu araştırma, dişlerinde MIH saptanan çocuklar ve bu çocukların ebeveynleri ile gerçekleştirilen bir anket çalışmasıdır. Bireylerden ve ailelerden bilgilendirilmiş onam formu alındıktan sonra, araştırmaya katılmayı kabul eden bireylere MIH’a karşı yaklaşımı ve MIH’ın bir ağız sağlığı sorunu olarak algılanıp algılanmadığını ölçen anket soruları yöneltilmiş ve eksiksiz bir şekilde anketleri cevaplamaları sağlanmıştır. Çocuklar kendi kararlarını verebilecek yeterlilikte olmadıkları için ebeveynlerinin de bu konu hakkında görüşleri ve aralarındaki görüş farklılıkları istatistiksel olarak spearman korelasyon testi, Mann Whitney U testi, Ki kare ve Fisher exact testi kullanılarak analiz edilmiştir.
Bulgular: Anket skorları karşılaştırıldığında MIH’ın ebeveynler ve çocuklar arasında farklı oranlarda bir ağız sağlığı sorunu olarak algılandığı görülmüştür. Ebeveyn skor ortalaması 22,63, çocuk skor ortalaması 20,85 (p=0,026) (p<0,05). Bu algı farkının, hastalık ancak yüksek şiddetli aşamaya geldiğinde ortaya çıktığı belirlenmiştir. Çocuklar ile ebeveynler arasında algı farkının ortaya çıkmasının altında yatan sebepler ise fiziksel etkenler olarak belirlenmiştir (r=0,446; p<0,05). Psikolojik skor ortalaması ebeveynlerde 11,77, çocuklarda 10.78 olarak saptanmıştır.
Sonuç: MIH görülen çocukların ebeveynleri, dişlerin görünüşü hakkında çocuklarına oranla daha üzgün ve daha endişeli hissetmektedir. Buna paralel olarak aileler çocuklarından daha fazla oranda tedavi gerektiği düşüncesindedirler.
Efficiency Of Self-Dental Esthetic Satisfaction And The Will Status On Choosing Dentistry As A Profession
Authors: YUCESOY Turker , SENGONUL Enes
Published: August 2021

Introduction: While other influencing factors are well categorized on the choice of dentistry, the effect of the-self appearance and the importance of the will are not studied adequately and categorized as an influencing factor in the literature.

Materials and Methods: The structured questionnaire with 21 questions was asked to 142 dental students in Turkey. Statistical analyses were performed and the results were obtained. The questions were designed by following the factors affecting the decision of the students in choosing careers such as; willingness, economy, esthetics, past experiences with dentists, the influence of family/environment, etc.

Results: Of the individuals who wanted to become a dentist from the beginning of their education, 82.5% replied as “Dentistry has always been closer and warmer” (p = 0.002; p
OFİS TİPİ BEYAZLATMA İŞLEMİNİN RENKLENDİRİLEN KOMPOZİT REZİN RESTORASYONLARA OLAN ETKİSİNİN İNCELENMESİ
Authors: GÖNDER Hakan Yasin , DERELİ Zeynep
Published: August 2021

Amaç:Bu çalışmanın amacı farklı solüsyonlar içerisinde bekletilen kompozit rezin örneklere ofis tipi bir beyazlatma ajan uygulanmasının etkisinin değerlendirilmesidir.
Giriş: Kompozit rezinlerin en önemli dezavantajı zaman içinde kompozit rezinlerde meydana gelen renklenmelerdir. Özellikle anterior bölgede bulunan estetik kompozit rezin restorasyonların yenilenmesinin en önemli nedeni, zaman içinde restorasyonlarda meydana gelen renk değişikliğidir. Renklenmenin giderilmesi için restorasyonun yenilenmesi, diş dokusunda daha fazla madde kaybına yol açmasının ve zaman kaybına neden olmasının yanı sıra, ekonomik olarakta çok tercih edilir bir yöntem değildir.
Gereç ve Yöntem: Bu çalışmada A1 renginde restoratif materyal Filtek™ Z550 Nano Hibrit Üniversal kullanıldı. Çalışmamızda 13 mm çapında ve 1,5 mm kalınlıkta dairesel boşluklara sahip bir politetrafloroetilen kalıp kullanılmıştır. Toplamda 40 adet örnek hazırlanmıştır (n=8). Restoratif materyaller su, çay, neskafe, kola ve kırmızı şarap olmak üzere 5 farklı solüsyon içinde, 30 gün süre ile renklendirildi. Renklenen kompozit materyalleri beyazlatmak için Opalescence® Boost Ofis Tipi Beyazlatma (%40 HP) kullanıldı.
Bulgular: Su ve kola birlikte; çay ve neskafe birlikte ve şarap da hepsinden daha yüksek ortalama renklenme değerine sahip olacak şekilde tek başına hareket etmiştir. Ağartma işlemi sonucunda elde edilen ortalama renklendirme değerlerinin tüm solüsyonlarda farklı olduğu görülmüştür. Ağartma işleminde elde edilen ortalama renklendirme miktarları sadece şarapta ortalama olarak düşüş göstermiştir. Diğer solüsyonlarda elde edilen tüm renklendirme ortalama miktarları ağartma işlemi sonucunda elde edilen ortalama miktarından daha küçük değere sahiptir(p<0,05).
Sonuç: Şarap gibi renklenmeyi çok fazla arttıran solüsyonlar için beyazlatma işlemi etkili olup renklenen kompozit rezinlerde rengin açılmasını sağlarken, renklenmesi olmayan kompozit rezinlerde rengin daha koyu veya opak olmasına neden olmuştur.
Dijital diş hekimliği hakkında bilgi kaynağı olarak YouTube’un değerlendirilmesi
Authors: YAĞCI Filiz
Published: August 2021

Amaç: Bu çalışmanın amacı diş hekimliğinde dijitale doğru bir dönüşüm yaşanılan bu dönemde, dijital diş hekimliği hakkında YouTube™ videolarının içerik kalitesinin ve demografik özelliklerinin değerlendirilmesidir.

Gereç ve Yöntemler: Google Trends internet sitesinde dijital diş hekimliği hakkında en çok arama yapılan terimin ‘dijital diş’ olduğu belirlendi. Bu anahtar kelime kullanılarak YouTube’da arama yapıldı ve en fazla görüntülenen 100 video içerisinden kriterleri karşılayan 54 video çalışmaya dahil edildi. Altı başlıktan oluşan bir kullanım kalitesi puan sistemi kullanılarak videolar içerik yönünden zayıf, orta ve iyi olarak sınıflandırıldı. Ayrıca "global kalite skalası" na göre de videolar değerlendirildi. İstatistiksel değerlendirme için verilere Kruskal-Wallis testi ile ikili karşılaştırmalar için Mann-Whitney U testi uygulandı (p < 0.05).

Bulgular: Videoların çoğunlukla (% 38.88) diş hekimleri tarafından yüklendiği, % 37.03’ünün dental şirketler tarafından yüklendiği ve bunu TV kanalları tarafından yüklenen videoların takip ettiği (% 24.07) görüldü. Diş hekimi kaynaklı videoların istatistiksel olarak anlamlı şekilde daha fazla görüntülenme (p = 0.036) ve beğenilme sayısına (p = 0.015) sahip olduğu görüldü. Kullanım kalitesi bakımından videoların % 18.51’i içerik olarak iyi, % 44.44’ü orta, % 37.03’ü ise zayıf bulundu.

Sonuç: YouTube video platformunda dijital diş hekimliği hakkındaki bilgilerin sınırlı olduğu görüldü. Bu alanda uzman diş hekimlerinin ve akademisyenlerin doğru bilgilerin paylaşılmasında daha fazla rol almasının yararlı olacağı düşünülmektedir.
The The effect of iron on precipitation hardening in the Cu-Ni-Mn alloys
Authors: Sukhova O.V.
Published: August 2021

The peculiarities in the structure and properties formation of precipitation-hardened Сu–Ni–Mn–Fe alloys within the concentration range of Ni (19.3–21.0 %), Mn (19.5–20.5 %), Fe (0.6–2.7 %), Cu – balance (in wt. %) were investigated in this work. The methods of quantitative metallography, X-ray analysis, scanning electron microscopy, energy-dispersive spectroscopy and differential thermal analysis were applied. Two solid solutions based on a-Cu differing in composition and hardness were found in the structure of the cast Сu–Ni–Mn–Fe alloys. The temperature ranges of solutions’ formation were determined as (1010±10) °С and (890±10) °С, correspondingly. NiMn phase was also formed at (405±15) °С due to precipitation hardening. In the Сu–Ni–Mn–Fe alloys annealed at 500 and 900 °С for 60–750 hours, the volume fraction and size of NiMn precipitates increased with prolonging annealing time and lowering annealing temperature. As iron content was raised up to 2.7 wt. %, the density of NiMn precipitates increased, especially during first 60 hours of annealing at 900 °С. By adding iron, oxidation resistance was improved, but melting temperature and fluidity did not yield any significant change. Hardness of the Сu–Ni–Mn–Fe alloys with higher iron contents increased by 10 НRB on average. However, when test temperature was raised up to 400 °С, tensile strength decreased (by ~1.3 times) and elongation dropped markedly (by ~10 times).
Interview: Von der Hörfunklandschaft zum Audiomarktin NRW: Für Einige drängt die Zeit
Authors: Schmid Tobias , Gerlach Petra
Published: August 2021

Heute hören rund 80 Prozent der Bundesbürgerinnen und -bürger täglich über drei Stunden Radio, doch die Audionutzung der Hörerinnen und Hörer fragmentiert sich dabei zunehmend. Diese Entwicklung hat sich in den vergangenen Jahren sukzessive beschleunigt. Der Lokalfunk in Nordrhein-Westfalen bewegt sich also inmitten eines attraktiven Audiomarktes, steht jedoch vor der Aufgabe, sich neuen Nutzungsgewohnheiten anpassen zu müssen. Dabei stellt vor allem die Veränderung der Verbreitungswege – vom analogen UKW hin zu digitalen Angeboten – eine besondere Herausforderung dar. Das nachfolgende Interview mit dem Direktor der Landesanstalt für Medien NRW, Dr. Tobias Schmid, und der Leiterin der Abteilung Medienpolitik und -ökonomie. Dr. Petra Gerlach, gibt vertiefende Einblicke in die Fragen der digitalen Transformation im Audiomarkt mit spezifischem Blick auf Nordrhein-Westfalen. Das Interview wird mit fünf Charts der Landesanstalt unterfüttert, die die gemachten Aussagen illustrieren.
Audio-Controlling
Authors: Reising Wolfgang
Published: August 2021

Bereits in der analogen Ära genoss das im Vergleich zum Massen- und Leitmedium Fernsehen nicht ganz so glamouröse, gleichwohl älteste und zudem erste mobile elektronische Massenmedium, der Hörfunk, als „Überall-Medium“ eine große Wertschätzung und ist für die große Mehrheit der Mediennutzer immer noch der wichtigste Tagesbegleiter in ihrem Lebensalltag. Durch Digitalisierung und Vernetzung entwickelte sich eine konvergente Medienwelt mit einer stark veränderten intra- bzw. intermedialen Wettbewerbsintensität und einer Umformung der Rezeptionsmodi durch die Nutzer. Entstanden ist ein durch das Internet geprägtes Mediensystem, das tradierte Grenzziehungen zwischen den klassischen Mediengattungen, zwischen interpersonaler und Massenkommunikation und zwischen Produzent und Rezipient verschwimmen lässt. Entstanden ist auch ein neues „Universum Audio“ (Flieger 2018). Vor diesem Hintergrund steht das Management der traditionellen Medienhäuser, ganz gleich ob Rundfunkanbieter oder Verlag, vor neuen strategischen und operativen Fragestellungen. Um den Transformationsprozess erfolgreich zu meistern, bedarf es eines ganzheitlichen und zielsystemorientierten Controllings. Das vorliegende Statement gibt einige Hinweise zum Performance Measurement und Reporting im Kontext der Führung von auditiver Format-, Genre- und Personalmarken.
Business Solutions in the B2B World - A Systematic Literature Review
Authors: Akalan Rodi
Published: August 2021

In an increasingly competitive environment, manufacturers are seeking for new ways of sustainable growth. Different resources (i.e., products, services, knowledge) are integrated into innovative business solutions to solve an entire customer problem. Business solution research is a dynamic research domain with a continuously increasing research output. This study provides a systematic literature review on business solution research. It reviews 355 articles from 1964 to 2020. On the one hand, the review’s objective is to develop a consistent definition and to retrace the evolutionary path of business solutions. On the other hand, the review aims to investigate outcomes and challenges of business solutions and uncover existing research gaps. These insights can help researchers to gain a quick and up-to-date snapshot of business solution research. Managers can benefit by understanding conceptual foundations of business solutions and potential risks, challenges, and outcomes.
Value Co-Creation and Co-Destruction in Health Care: Analyzing Citizenship and Dysfunctional Patient Behavior in Nurse-Patient Encounters
Authors: Hendricks Jennifer , Schmitz Gertrud , Ates Zelal , Büttgen Marion
Published: August 2021

Patients interact with various health care service network partners, whereby nurses play an integral role in providing health care services on the patient level. Drawing on social exchange theory and considering citizenship and dysfunctional patient behavior from a value co-creation (and even co-destruction) perspective, the purpose of the present study is to identify drivers that promote citizenship and reduce dysfunctional patient behavior in service interactions with nurses at the same time. Using PLS-SEM and survey data from 404 inpatients, results demonstrate the importance of perceived citizenship behavior of nurses for patient citizenship behavior by showing a significant direct effect (and partially even an indirect effect mediated by patients’ positive emotions) on all identified forms. However, it provides little chances to reduce dysfunctional patient behaviors, as there hardly exists any significant (direct or indirect) effect.
Existence of a unique solution for a third-order boundary value problem with nonlocal conditions of integral type
Authors: Smirnov Sergey
Published: August 2021

The existence of a unique solution for a third-order boundary value problem with integral condition is proved in several ways. The main tools in the proofs are the Banach fixed point theorem and the Rus’s fixed point theorem. To compare the applicability of the obtained results, some examples are considered.
Finite-time stabilization of discontinuous fuzzy inertial Cohen–Grossberg neural networks with mixed time-varying delays
Authors: Kong Fanchao , Zhu Quanxin , Sakthivel Rathinasamy
Published: August 2021

This article aims to study a class of discontinuous fuzzy inertial Cohen–Grossberg neural networks (DFICGNNs) with discrete and distributed time-delays. First of all, in order to deal with the discontinuities by the differential inclusion theory, based on a generalized variable transformation including two tunable variables, the mixed time-varying delayed DFICGNN is transformed into a first-order differential system. Then, by constructing a modified Lyapunov–Krasovskii functional concerning with the mixed time-varying delays and designing a delayed feedback control law, delay-dependent criteria formulated by algebraic inequalities are derived for guaranteeing the finite-time stabilization (FTS) for the addressed system. Moreover, the settling time is estimated. Some related stability results on inertial neural networks is extended. Finally, two numerical examples are carried out to verify the effectiveness of the established results.
Time-periodic Poiseuille-type solution with minimally regular flow rate
Authors: Kaulakytė Kristina , Kozulinas Nikolajus , Pileckas Konstantin
Published: August 2021

The nonstationary Navier–Stokes equations are studied in the infinite cylinder Π = {x = (x', xn) ∈ Rn:  x' ∈ σ ∈ R n – 1: – ∞ < xn < ∞, n = 2, 3} under the additional condition of the prescribed time-periodic flow-rate (flux) F(t). It is assumed that the flow-rate F belongs to the space L2(0, 2π), only. The time-periodic Poiseuille solution has the form u(x, t) = (0, ... , 0, U(x', t)),  p(x,t) = –q(t)xn + p0(t), where (U(x', t), q(t)) is a solution of an inverse problem for the time-periodic heat equation with a specific over-determination condition. The existence and uniqueness of a solution to this problem is proved.
Influence of the isoelectric point of gelatin on its adsorption on nanosilica surface
Authors:   Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine, Voronin E. P. , Golovkova L. P. ,   Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine, Nosach L. V. ,   Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine, Los S. L. ,   Scientific-Production Company Ltd. “Ecokremniy” Russian Federation
Published: August 2021

The joint efforts of chemists, physicians and technologists conducting researches to create new medical sorbents and combined drugs based on nanosilica, which have not only a detoxifying effect, but also antibacterial, wound healing, hemostatic and other important properties. One of the stages of such a research is developing regulatory documentation. To control the quality of the sorbent, the method of point measurements is most often used, according to it, the amount of adsorption of the marker substance at the single point of the adsorption curve is determined. The suitability of sorbents based on nanosilicа for using is determined by the value of the adsorption capacity concerning to medical gelatin. No other requirements for the process of test adsorption of gelatin by the sorbent are given. although it is known that the adsorption of proteins depends on the pH of the solution. Its maximum value is reached at a pH value corresponding to the isoelectric point (pI) of the protein. Each protein can be characterized by its own isoelectric point. Domestic and foreign standards give only the value of “pH of aqueous solutions” of gelatin and do not contain the indicator “isoelectric point”. The aim of the work is to study the influence of the isoelectric point of gelatin on its adsorption on nanosilica surface at different pH to appreciate the suitability of conditions for determining the adsorption activity of medical sorbents based on nanosilica. The adsorption of three samples of gelatin was examined in the work: A – edible gelatin (pI = 4.3–4.8); B – that from the catalog “Merck” (pI = 4.3–4.8) and C – that from the catalog “Fluka” (pI = 7.5–7.7) on nanosilica surface in the pH range from 3 to 8. It has been shown that for samples A and B the dependence has a maximum at pH ~ 4.5–5; and for sample C, the adsorption increases monotonically with increasing pH. It was noted that at pH ~ 5 the adsorption values for all gelatin samples were approximately equal. The adsorption activity of nanosilica concerning to proteins determined from the isotherms and the method of point measurements is compared. It has been found that the adsorption value of gelatin A onto the nanosilica at Cinitial = 700 mg/100 ml is equal to the Aave value determined by the Langmuir isotherms. This fact verifies the applicability of the method of point measurements for nanosilica/gelatin system to characterize the pharmacological activity of nanosilica based sorbents.
IR spectral manifestation of tin impurity sites in titanium dioxide
Authors:   Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine, Smirnova O. V. , Grebenyuk A. G. ,   Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine, Lobanov V. V. ,   Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine, Khalyavka T. A. ,   Institute for Sorption and Problems of Endoecology of National Academy of Sciences of Ukraine, Shcherban N. D. ,   L.V. Pisarzhevskii Institute of Physical Chemistry of National Academy of Sciences of Ukraine, Shapovalova M. V. ,   Institute for Sorption and Problems of Endoecology of National Academy of Sciences of Ukraine, Permyakov V. V. ,   Institute of Geological Sciences of National Academy of Sciences of Ukraine
Published: August 2021

It is known that titanium dioxide as photocatalyst has significant drawback - limited absorption spectrum in the ultraviolet region makes it impossible to use solar energy. To expands the absorption spectrum of TiO2, the doping of impurities (metal, non-metal, etc.) were used. They affected the electronic structure and spectral characteristics of TiO2. The aim of our work was to investigate the influence of tin impurities on spectral characteristics of titanium dioxide using experimental and theoretical methods. The TiO2 powders modified by different amount of tin (Sn/TiO2) were synthesized by sol-gel method. The samples were characterized by SEM, EDX, FT-IR and UV-VIS spectroscopy. It has been found that Sn/TiO2 consists of fragmented agglomerates in the range of 5–10 mm. EDX spectroscopy prove that powders include Ti, O and Sn elements. Modification of titanium dioxide with tin leads to band gap narrowing of samples, which explains by insertion of Sn atoms into crystal lattice of titanium dioxide, because Ti4+ and Sn4+ ions radii are close. The band gap values increased with increasing of tin content. The work also analyzes the vibrational spectra of Sn/TiO2 both experimentally and theoretically. In order to interpret the results obtained, quantum chemical calculations on the spatial and electronic structures of cluster models of titanium dioxide (anatase) with inserted tin atoms using the density functional theory B3LYP method and the basis set 6-31G (d, p) were carried out and the corresponding FT-IR spectra have been simulated. By comparing the experimental and theoretical results, the influence has been analyzed of the number and arrangement of impurity tin atoms in clusters on the observed IR spectra of the samples. This makes it possible to forgive the most probable structural motives of titanium dioxide particles doped with tin atoms, as well as to establish the fact of the presence of tin atoms in the samples. Based on the comparison of the IR spectra of samples with different numbers of tin atoms, it is possible to quantify their composition.
The triad “electrode – solid electrolyte interphase – electrolyte” as a ground for the use of conversion type reactions in lithium-ion batteries
Authors:   Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine, Kuksenko S. P. , Kaleniuk H. O. ,   Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine, Tarasenko Yu. O. ,   Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine, Kartel M. T. ,   Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine
Published: August 2021

The solution to the problem of negative impact on the ecology of fossil fuel consumption is the use of electrochemical energy sources. The special attractiveness has shown of lithium power sources is highlighted and the need to develop new cheap electrode materials and electrolytes with unique properties. The peculiarities of the behavior of lithium and the formation of a layer of reaction products on its surface upon contact with a liquid organic electrolyte have considered. The analysis of the main problems and ways of their solution at use of conversion electrodes of the II type for lithium-ion batteries has carried out. Emphasis is placed on the need to use in the development of new electrode materials of such parameters as capacity loading and accumulated irreversible capacity of the electrodes. The triad “electrode – solid electrolyte interphase – electrolyte” is considered as a basis of a systematic approach to the creation of new generations of lithium power sources. The optimal scenarios have proposed for the formation of an effective solid electrolyte interphase on the surface of the electrodes. The advantages of electrolytes based on fluoroethylene carbonate with synergistic acting additives of vinylene carbonate and ethylene sulfite are described. A new strategy for the use of “secondary” silicon nanomaterials to prevent direct contact of its surface with the electrolyte has considered. It has shown that the solid electrolyte interphase is a dynamic system that self-organizes from the unstable state into a stable one. The electrochemical behavior of electrodes with silicon nanocomposites with high capacity loading and low accumulated irreversible capacity has described.
Generación de péptidos antimicrobianos mediante redes neuronales recurrentes
Authors: Veléz Andres , Mera Carlos Andres , Orduz Sergio , Branch John Willian
Published: August 2021

Los péptidos antimicrobianos (AMP) han tomado importancia en el desarrollo de nuevos antibióticos debido a su papel como inhibidores, no solo de bacterias sino también de virus, hongos y parásitos, entre otros. Desde el descubrimiento de los AMP, se han reportado miles, sin embargo, muchos de ellos no son adecuados para aplicaciones terapéuticas debido a sus largas secuencias de aminoácidos, baja potencia antimicrobiana y altos costos de producción. En este trabajo, proponemos utilizar redes neuronales recurrentes (RNN) con células LSTM para generar péptidos más potentes y económicos. Realizamos diferentes experimentos generando AMP sintéticos entre 12 y 20 aminoácidos. Los resultados muestran que podemos usar RNN y mejorar el proceso de generación en comparación con el método de plantillas manuales.
Diagnóstico descentralizada de fallas entre espiras de motores de inducción basado en redes inalámbricas de sensores
Authors: Caballero Jairo , Rosero Javier
Published: August 2021

El diagnóstico de fallas de motores ha alcanzado múltiples avances e integrado diversas técnicas de análisis y clasificación de datos proporcionando ventajas como tolerancia al ruido, a cambios en el punto de operación o transitorios; pero requieren ser analizadas para lograr su integración en dispositivos programables e identificar sus mejoras; por ello, se desarrolló e implementó un sistema de diagnóstico descentralizado de fallas de motores de inducción basado en redes inalámbricas de sensores - WSN con una clasificación de datos basado en Support Vector Machine – SVM. En este trabajo se plantearon indicadores basados en la medición de las corrientes de estator (Motor-Current Signature Analysis - MCSA), Fast Fourier Transform - FFT y Discrete Wavelet Transform - DWT con los cuales se logró validar el sistema e identificar un comportamiento diferenciado de falla entre espiras como un antecedente de fallas críticas al presentarse como un deterioro del aislamiento.
Bibliometric analysis of engineering publications in Colombia, 2010-2019: a Scopus analisis
Authors: Gomez Rosselli Simon , Rosselli Diego
Published: August 2021

This article analyses scientific publishing trends in engineering in Colombia during the decade from 2010 to 2019. Methodology: All publications classified under engineering affiliated to a Colombian institution in Scopus database were selected. Number of publications, citations, self-citations as well as H indexes were collected for the country’s top researchers and institutions. Results: Universidad Nacional and Universidad de Antioquia have the highest overall (general) research outputs. However, Universidad de los Andes has a higher output in engineering publications than Universidad de Antioquia. From the top five universities, Universidad de los Andes and Universidad Nacional had the highest growth in engineering during this decade. Conclusions: Colombia’s engineering scientific output grew 80% during this decade. Authors with high number of publications were not necessarily affiliated to the universities with higher scientific output.
História em Quarentena
Authors: Gomes Paulo Cesar , Trinidad Carlos Benitez
Published: August 2021

História em Quarentena foi um projeto de história pública elaborado com o intuito de lidar com as incertezas geradas pela crise sanitária decorrentes da pandemia da covid-19, propondo refletir sobre temas ligados à divulgação do conhecimento histórico. A partir dos parâmetros teórico-metodológicos da história pública, este artigo analisa as principais diretrizes que balizaram o projeto História em Quarentena, além de narrar seu desenvolvimento e avaliar seus resultados. Nessa discussão, ganham especial relevância a percepção de sucesso e fracasso, a importância da história pública como ferramenta para ampliar a inserção do conhecimento histórico na esfera pública em momentos de crise e, também, os desafios de construir um empreendimento dessa natureza diante das dificuldades criadas pela pandemia. As transformações da proposta inicial do projeto, ocorridas ao longo de seu desenvolvimento, podem funcionar como uma chave de compreensão sobre os obstáculos que a história pública enfrenta para atrair um público amplo. Indica-se, ainda, a necessidade de os historiadores estarem atentos às questões postas pelo presente para facilitar o estabelecimento de diálogos com a sociedade, evitando que as produções historiográficas circulem apenas entre seus pares.
A karboplatin-kemoterápia hatékonysága egy áttétes, kasztrációrezisztens, BRCA2-mutáció-pozitív prosztatarákos betegben
Authors: Nagy Noémi Dalma , Fazekas Tamás , Baghy Kornélia , Papp Gergő , Csizmarik Anita , Szűcs Miklós , Nyirády Péter , Szarvas Tibor
Published: August 2021

Összefoglaló. A sérült BRCA1/2 gént hordozó
prosztatadaganatok klinikai szempontból elkülönülő, agresszív altípust
képviselnek. Ugyanakkor a BRCA1/2 gén sérülése a
DNS-támadáspontú kemoterápiákkal szemben érzékennyé teszi a daganatot, ami
terápiás szempontból kihasználható. A platinaalapú kemoterápia hatékonysága
prosztatarákban klinikai vizsgálatokkal nincs alátámasztva, ezért annak
alkalmazására igen ritkán kerül sor. Közleményünkben egy előrehaladott stádiumú,
agresszív prosztata adenocarcinomával diagnosztizált beteg esetét mutatjuk be,
akinél a BRCA2-gén patogén mutációját találtuk, és akinél az
előzőleg alkalmazott androgénmegvonásos, valamint docetaxelkezelések
sikertelensége miatt karboplatinkezelést alkalmaztunk – ez a beteg állapotának,
valamint radiológiai és biokémiai paramétereinek látványos javulásához vezetett.
Ez az eset rámutat a DNS-hiba-javító mechanizmusban szerepet játszó gének
terápiás szempontból történő felhasználásának potenciális előnyeire
prosztatarákban. Orv Hetil. 2021; 162(25): 1004–1008.

Summary.
BRCA1/2 deficient prostate cancers represent a clinically
distinct aggressive subtype. However, the presence of BRCA1/2
alterations enhance the sensitivity to platinum-based chemotherapies. The
efficacy of platinum-based chemotherapies in prostate cancer has not been proven
in prospective clinical studies and therefore these treatments are rarely used
in prostate adenocarcinomas. Here we present a case of BRCA2
mutant prostate cancer, which was diagnosed at a metastatic stage and showed no
or only little response to androgen deprivation and docetaxel therapies.
Therefore, we started carboplatin chemotherapy which resulted in an exceptional
response regarding biochemical, radiographic parameters accompanied by
significant improvement of patients’ physical condition. This case underlines
the potential therapeutic benefits of testing for genes involved in the DNA
repair mechanism. Orv Hetil. 2021; 162(25): 1004–1008.
Periorbitalis bőrtünetekkel járó könnyűlánc-amyloidosis
Authors: Haász Csilla , Kuroli Enikő , Anker Pálma , Márton Dalma Fanni , Szigeti Ágnes , Nagy Zsolt , Demeter Judit , Sárdy Miklós , Medvecz Márta
Published: August 2021

Összefoglaló. A könnyűlánc-amyloidosis ritka, multidiszciplináris
jelentőségű kórkép, melynek hátterében az esetek döntő hányadában egy
amyloidogen fehérje, a csontvelő kóros plazmasejtjeiben termelődő
monoklonálisimmunglobulin-molekula lambda típusú könnyűláncának felszaporodása
áll. A klinikai tünetek az érintett szervek függvényében igen változatosak és
gyakran nem specifikusak, ezért a betegség sok esetben későn kerül felismerésre.
A diagnózis felállításának alapfeltétele a szövettani vizsgálat elvégzése és a
kóros fehérjelánc kimutatása. A betegség jellegzetes alarmírozó bőrtüneteinek
helyes értékelése fontos szereppel bír a korai diagnózisalkotásban. A jelen
közlemény egy myeloma multiplexhez társult könnyűlánc-amyloidosis esetét mutatja
be. A betegnél a pathognomicus, típusos bőrgyógyászati tünetek (periorbitalis,
axillaris és inguinalis lokalizációjú petechiák, purpurák, ecchymosisok,
suffusiók és viaszsárga papulák) mellett szív- és veseérintettség is
igazolódott. Az alkalmazott ciklofoszfamid-, bortezomib- és dexametazonkezelési
séma hatására a csontvelőben komplett morfológiai remisszió következett be, a
beteg a jelenleg legjobb túlélést biztosító autológőssejt-transzplantáció előtt
áll. Orv Hetil. 2021; 162(32): 1303–1308.

Summary. Amyloid light-chain amyloidosis is a rare disease with
diverse signs and symptoms according to the affected organs. The signs are often
aspecific which can lead to delayed diagnosis. Considering the characteristic
cutaneous manifestations of the disease, dermatologists have an important role
in early identification. Additionally, histopathological examination is required
for diagnosis. Here we present a rare case of light-chain amyloidosis in
association with multiple myeloma. The patient presented with characteristic
periocular, axillar and inguinal petechiae, purpurae, ecchymoses, suffusions,
yellowish-brown waxy papules and plaques besides cardiovascular and renal
involvement. In this case, the amyloidogenic proteins are the lambda-chains of
monoclonal immunoglobulins secreted by the clonally expanded plasma cells of the
bone marrow. The applied cyclophosphamide, bortezomib and dexamethason treatment
induced complete morphological remission in the bone marrow and the patient
currently awaits autologous stem cell transplantation which yields the longest
possible survival. Orv Hetil. 2021; 162(32): 1303–1308.
Új célzott terápiás lehetőség az onkológiában: tropomiozin receptor-tirozin-kináz gátlók
Authors: Kiss Edina , Pápai Zsuzsanna
Published: August 2021

Összefoglaló.A molekuláris diagnosztikai módszerek folyamatos fejlődésének köszönhetően egyre több onkogén genetikai eltérést azonosítanak. A neurotrofikus tropomiozin receptor-tirozin-kináz (NTRK-) génfúziók fontos precíziós onkológiai célpontok, melyek mindháromNTRK-génben előfordulhatnak, onkogén-hajtóerőként viselkednek. A génfúziók különböző molekuláris diagnosztikai módszerekkel azonosíthatók, melyek közül a legpontosabb, legköltségesebb és legidőigényesebb meghatározást az újgenerációs szekvenálási technika jelenti. A tropomiozin receptor-tirozin-kináz (TRK-) fúziós fehérjék szelektív gátlása személyre szabott onkológiai kezelési lehetőséget jelent a tumor típusától, lokalizációjától és a beteg életkorától függetlenül. Az első generációs TRK-gátlók gyors, hatékony és tartós daganatellenes hatást biztosítanak kimutatottNTRK-fúzió-pozitív daganatok esetén, alacsony mellékhatásprofil mellett. Az első generációs TRK-gátlók mellett jelentkező ’on target’ rezisztenciát a második generációs TRK-gátlók oldják fel. Szekvenciális tirozin-kináz-inhibitor-kezeléssel tartós betegségmentes túlélés érhető el. Orv Hetil. 2021; 162(34): 1362–1369.

Summary.Due to the continuous development of molecular diagnostic methods, more and more oncogenic genetic abnormalities are being identified. Neurotrophic tropomyosin receptor tyrosine kinase(NTRK)gene fusions are important precision oncology targets that can occur in all threeNTRKgenes and act as oncogenic drivers. Gene fusions can be identified by a variety of molecular diagnostic technologies, of which next-generation sequencing is the most accurate, costly and time-consuming determination. Selective inhibition of tropomyosin receptor tyrosine kinase (TRK) fusion proteins represents a personalized oncology treatment option regardless of tumour type, localization and patient age. First-generation TRK inhibitors provide rapid, efffective and long-lasting antitumor activity inNTRKfusion-positive tumors with a low side-effect profile. On target resistance to first-generation TRK inhibitors is resolved by second-generation TRK inhibitors. Durable disease-free survival can be achieved with sequential tyrosine kinase inhibitor therapies. Orv Hetil. 2021; 162(34): 1362–1369.
A mitralis billentyű sebészete atrioventricularis septumdefektusban
Authors: Hartyánszky István , Bogáts Gábor
Published: August 2021

Összefoglaló. A veleszületett szívbetegségek egyik gyakori formáját
jelentő atrioventricularis septumdefektus korrekciós műtétjének kritikus pontja
a közös atrioventricularis szájadék elválasztásával a mitralis billentyű
kialakítása. A korrekció sikere számos anatómiai variáns függvénye, ezért nem
lehet minden esetben a tökéletes anatómiai viszonyokat kialakítani. A fennmaradó
billentyűstenosisok, regurgitatiók a későbbi életkorban progressziót mutatva
olyan hemodinamikai kórképeket, keringési elégtelenséget okozhatnak, melyek
további beavatkozásokat igényelhetnek. A mitralis billentyűnek az
atrioventricularis septumdefektushoz társuló betegsége koraszülöttkortól
aggkorig minden életkorban előfordul, más-más műtéti megoldást igényelve. A
szerzők részletezik a különböző életkorokra vonatkozóan a napjainkban lehetséges
és szükséges műtéti megoldásokat, sebészi kihívásokat. A mitralis billentyű
műbillentyűre történő cseréjében a klasszikus sebészi megoldások mellett
napjainkban új beavatkozásokként jelentős számban jelentkeznek a katéteres
intervenciós és hibrid megoldások. A felnőttkort egyre nagyobb számban megélő
betegek fokozott odafigyelést, speciális ellátást igényelnek a kardiológusoktól,
szívsebészektől. Orv Hetil. 2021; 162(35): 1397–1401.

Summary. The critical point of the atrioventricular septal defect
correction is to separate the common atrioventricular orifice, which results in
the reconstruction of the mitral valve. The success of the correction depends on
many anatomical aspects, therefore a perfect anatomical outcome is not always
possible. The remaining valvular stenoses and regurgitations, showing
progression at a later age, may result in hemodynamic disorders and circulatory
insufficiency that may require further interventions. Mitral valve disease
associated with atrioventricular septal defect occurs at all ages from preterm
to adulthood, requiring different surgical solutions. The authors detail the
possible and necessary surgical solutions and surgical challenges at different
ages. In addition to the classic surgical solutions, a significant number of
catheter interventional and hybrid solutions are emerging as new interventions
in the replacement of the mitral valve with an artificial valve. An increasing
number of patients living in adulthood require increased attention and special
care from cardiologists and cardiac surgeons. Orv Hetil. 2021; 162(35):
1397–1401.