bluuebunny/crossref_metadata_2025 huggingface dataset:
Acrylamide-targeting renal miR−21a−5p/Fibrotic and miR122-5p/ inflammatory signaling pathways and the role of a green approach for nano-zinc detected via in silico and in vivo approaches
Authors: Alqahtani Leena S. , Alosaimi Manal E. , Abdel-Rahman Mohamed Amany , Abd-Elhakim Yasmina M. , Khamis Tarek , Noreldin Ahmed E. , El-Far Ali H. , Alotaibi Badriyah S. , Hakami Mohammed Ageeli , Dahran Naief , Babteen Nouf A.
Published: July 2024

Introduction: Any disruption in renal function can have cascading effects on overall health. Understanding how a heat-born toxicant like acrylamide (ACR) affects kidney tissue is vital for realizing its broader implications for systemic health.

Methods: This study investigated the ACR-induced renal damage mechanisms, particularly focusing on the regulating role of miR-21a-5p/fibrotic and miR-122-5p/inflammatory signaling pathways via targeting Timp-3 and TP53 proteins in an In silico preliminary study. Besides, renal function assessment, oxidative status, protein profile, and the expression of renal biomarkers (Timp-1, Keap-1, Kim-1, P53, TNF-α, Bax, and Caspase3) were assessed in a 60-day experiment. The examination was additionally extended to explore the potential protective effects of green-synthesized zinc oxide nanoparticles (ZNO-MONPs). A four-group experiment including control, ZNO-MONPs (10 mg/kg b.wt.), ACR (20 mg/kg b.wt.), and ZNO-MONPs + ACR was established encompassing biochemical, histological, and molecular levels. The study further investigated the protein-binding ability of ZNO and MONPs to inactivate caspase-3, Keap-1, Kim-1, and TNFRS-1A.

Results: ZNO-MONPs significantly reduced ACR-induced renal tissue damage as evidenced by increased serum creatinine, uric acid, albumin, and oxidative stress markers. ACR-induced oxidative stress, apoptosis, and inflammationare revealed by biochemical tests, gene expression, and the presence of apoptotic nuclei microscopically. Also, molecular docking revealed binding affinity between ACR-BCL-2 and glutathione-synthetase, elucidating the potential mechanisms through which ACR induces renal damage. Notably, ZNO-MONPs revealed a protective potential against ACR-induced damage. Zn levels in the renal tissues of ACR-exposed rats were significantly restored in those treated with ACR + ZNO-MONPs. In conclusion, this study establishes the efficacy of ZNO-MONPs in mitigating ACR-induced disturbances in renal tissue functions, oxidative stress, inflammation, and apoptosis. The findings shed light on the potential renoprotective activity of green-synthesized nanomaterials, offering insights into novel therapeutic approaches for countering ACR-induced renal damage.
Drivers and epidemiological patterns of West Nile virus in Serbia
Authors: Marini Giovanni , Drakulovic Mitra B. , Jovanovic Verica , Dagostin Francesca , Wint Willy , Tagliapietra Valentina , Vasic Milena , Rizzoli Annapaola
Published: July 2024

Background

West Nile virus (WNV) is an emerging mosquito-borne pathogen in Serbia, where it has been detected as a cause of infection in humans since 2012. We analyzed and modelled WNV transmission patterns in the country between 2012 and 2023.

Methods

We applied a previously developed modelling approach to quantify epidemiological parameters of interest and to identify the most important environmental drivers of the force of infection (FOI) by means of statistical analysis in the human population in the country.

Results

During the study period, 1,387 human cases were recorded, with substantial heterogeneity across years. We found that spring temperature is of paramount importance for WNV transmission, as FOI magnitude and peak timing are positively associated with it. Furthermore, FOI is also estimated to be greater in regions with a larger fraction of older adult people, who are at higher risk to develop severe infections.

Conclusion

Our results highlight that temperature plays a key role in shaping WNV outbreak magnitude in Serbia, confirming the association between spring climatic conditions and WNV human transmission risk and thus pointing out the importance of this factor as a potential early warning predictor for timely application of preventive and control measures.
A systematic literature review exploring the nexus between circular economy and communities
Authors: Ceddia Anna Rita , Oricchio Stefano , Barberio Grazia , Innella Carolina
Published: July 2024

Circular Economy (CE) studies often focus primarily on technical and economic aspects of the transition process. Recently, some authors have started to enquire the social processes connected to of the CE, often referring to communities. This article provides a Systematic Literature Review on the nexus between CE and community to investigate its features according to the experiences reported in the collected documents. The retrieved corpus has been analyzed recurring to consolidated frameworks, as the R hierarchy, the societal areas challenges identified by the Strategic Research and Innovation Agenda developed by the EU project CICERONE, and to the spectrum of participation provided by the International Association for Public Participation. The participative dynamics found in the corpus are analyzed also considering the type of communities, tools, methodologies and goals reported in the retrieved documents. Besides descriptive statistics about the mentioned aspects, the article includes a discussion on some CE social aspects, problematizing and questioning the retrieved stakeholders engagement practices, recurring to a qualitatively selected literature. Conclusions address the main findings related to the most commonly found R strategy, community type, societal challenge areas and type of participative dynamics according to the analytical components chosen in the methodology. Research implications are illustrated, suggesting possible directions for future research to widen the analysis on the nexus between CE and communities.
A critical review of biomonitoring in East African rivers: fostering community-based collaboration for environmental change observation
Authors: Kitaka Nzula , Omondi Lorine A. , Mureithi Priscilla W. , Bauer Andreas , Melcher Andreas , Ssanyu Grace A.
Published: July 2024

The contribution of citizen scientists to environmental monitoring is notably increasing significantly. Governments worldwide establish Water Users Associations (WUAs) as a good practice model to implement Integrated Water Resource Management (IWRM) at local levels. These associations target different stakeholders depending on the expected outcome. However, their effectiveness, especially in East Africa, can only be determined case by case. In Kenya, Water Resources Users Associations are registered, voluntary community groups whose members are water users and land owners. Similarly, in Uganda, community-based initiatives exist, especially along degraded rivers, involving cooperation between local communities and regional water authorities. On the contrary, it has been reported that in Tanzania, many community initiatives created become non-functional within 2–3 years of induction. In general, the main responsibility of Water Users Associations or its equivalent is to manage and conserve water resources for sustainable uses. In most cases, water quality monitoring by communities through citizen science is limited to the visual appearance of water in the river channel. While this can indicate the water’s esthetic value, it is insufficient for assessing the ecological status of rivers, which is influenced by a variety of physical, chemical, biological, and socioeconomic factors. The use of bioindicators has been advocated as a feasible method for community-based water quality river monitoring. Therefore, this review explores the commonly used bio-indicators and bio-assessment tools for river health assessment and their complexities when using a biomonitoring community-based approach through citizen science. Tolerance and intolerance macroinvertebrate and fish metric protocols that utilize identification keys have been recommended. These protocols are designed to be user-friendly and require minimal taxonomic expertise, making them easy for community volunteers to use with minimal basic training. The sustainability of these citizen science initiatives relies on the motivation of volunteers, the frequency of monitoring activities, and collaboration with researchers and government agencies. These initiatives not only facilitate environmental monitoring but also foster community engagement and awareness regarding the ecological status of rivers, thereby addressing knowledge and data gaps necessary for effective policy-making. This approach provides a practical model for environmental stewardship and participatory resource management in East Africa.
Predictive uncertainty analysis for a highly parameterized karst aquifer using null-space Monte Carlo
Authors: Baalousha Husam Musa
Published: July 2024

Inverse problems in hydrogeology pose a great challenge for modelers as they are ill-posed, resulting in a non-unique solution. High computational resources are needed for the calibration process, especially in the case of highly parameterized aquifers like karst limestone, characterized by significant heterogeneity. The null-space Monte Carlo (NSMC) is a parameter-constrained Monte Carlo approach that can be used to quantify uncertainty, as it produces a set of solutions that calibrate the model. This method is used to assess uncertainty in the calibration of a karst aquifer in Qatar, which has high heterogeneity. Pilot points were used to reflect the geostatistics of the calibrated field, and the calibration results at these points were interpolated over the aquifer area using kriging. The NSMC was then used to produce 200 realizations of the null-space parameter field using the constrained random variable of hydraulic conductivity. The null-space realizations were then incorporated into the parameter space derived from the calibrated model. Statistical analysis of the calibrated hydraulic conductivity revealed a variation ranging from 0.1 to 350 m/d, indicating a considerable variability in the aquifer’s hydraulic parameters. The areas with high hydraulic conductivity were concentrated in the central and eastern parts of the aquifer, and these same areas exhibited a high standard deviation. Based on the findings of this study, while the NSMC method is effective for uncertainty analysis in solving inverse problems, it is important to note that a considerable number of runs are necessary to reach the threshold of calibration error. This is because of the significant non-linearity inherent in the karst aquifer.
Determining the tactical and technical level of competitive tennis players using a competency model: a systematic review
Authors: Crespo Miguel , Martínez-Gallego Rafael , Filipcic Ales
Published: July 2024

Introduction

The aim of this systematic review is to provide an evidence-based synthesis of the literature on the topic of technical and tactical competencies of tennis players and to answer the following research questions: (1) What is the state of the art of research on technical and tactical competencies (i.e., skills and knowledge) and tennis; (2) What are the most important topics related to technical and tactical competencies in tennis players.

Methods

Electronic searches were conducted in Web of Science, PubMED and SPORTDiscus (August to September 2023). This systematic review was conducted in accordance with PRISMA guidelines. To reduce risk, all published literature was searched and primary studies were included. The search terms included skills or competencies, match or play, player and tennis and excluded studies on non-competitive tennis players—notation analysis, AI method, systematic review and validation of tools.

Results and discussion

Of the 390 publications found in these searches, 13 articles were considered relevant and included in this study. They were divided into three categories: (1) technical-tactical skills, (2) match situations and (3) match performance. There was clear evidence that there is a test instrument for analyzing tactical-technical skills that has sufficient reliability and validity and is of practical value to tennis coaches. The development of tactical-technical skills is influenced by method (variability between/within skills), conditions (court size, ball type) and areas of development (situational awareness, anticipation, decision making). There are differences in match and stroke performance between different quality groups (professionals, juniors), which can also be influenced by mental strength. For a comprehensive study of tennis players’ abilities, the use of modern technologies is possible and necessary in the future. Future research should focus on the creation of competency models for the playing level of tennis players, which could include at least three key elements: (1) key competencies, (2) description of standards, (3) evidence.
Why are farmers reluctant to accept biological inputs? a structural equation model of technology adoption
Authors: Forouzani Masoumeh , Bondori Abolmohammed , Mombini Ameneh Savari
Published: July 2024

Today, chemical inputs play an important and crucial role in increasing the production rate of agricultural products and the income of farmers in Iran. However, in parallel with this beneficial effect, the widespread and indiscriminate use of such inputs is considered to be one of the most significant barriers to environmental sustainability in Iran. The main objective of this research is to model the acceptance of the use of biological inputs among farmers living in the southwest of Iran. The research study was conducted using the cross-sectional survey method. The statistical population included all farmers of Meidavoud district located in Baghmalek county, southwest of Iran (N = 1,400). A sample of 302 individuals was selected according to Morgan’s sample size table and random sampling method. A questionnaire was used to collect the data, the validity of which was confirmed by a panel of experts, and its reliability was approved by various coefficients. The data were analyzed using SPSSV26, Smart PLS3, and AMOS software. The results of the structural equations showed that among the variables influencing farmers’ behavior toward biological inputs, the attitude and willingness variables could predict 80% of the variation in farmers’ behavior. In addition, attitude, ease of use, and usefulness were identified as effective factors in farmers’ willingness to use biological inputs. According to the results of the path analysis, the variables perceived usefulness and ease of use could predict 67% of the changes in farmers’ attitudes. To convince farmers and promote desirable attitudes that, in turn, influence their willingness to use biological inputs, some persuasive interventions seem to be necessary. Farmers need to be externally or internally motivated if they adopt environmentally friendly practices such as use of biological inputs.
Calcaneal distraction vs. cast immobilization for the preoperative treatment of patients with Danis–Weber type C ankle fractures: a case–control study
Authors: Song Bing , Shi Jisheng , Xu Xiaohui , Hou Xiangfeng , Jia Jingkun , Pang Tongtao
Published: July 2024

Introduction

Ankle fractures require temporary fixation to allow swelling to subside prior to surgery; this is typically achieved using calcaneal distraction or cast immobilization. We compared the results of these methods in the treatment of Danis–Weber type C ankle fractures.

Methods

This retrospective study analyzed the data of 86 patients with Danis–Weber type C ankle fractures, of whom 40 underwent calcaneal distraction and 46 underwent cast immobilization. Clinical measures including preoperative detumescence time, daily swelling value, skin condition, and pain, SF-36 Health Survey (SF-36) score and ankle scores were compared between the two groups.

Results

Baseline characteristics did not differ significantly between the groups. Calcaneal distraction resulted in a lower preoperative detumescence time (6.22 ± 0.64 vs. 8.94 ± 0.82 days) and lower daily swelling values compared with cast immobilization, leading to a lower skin necrosis rate. Resting pain scores were significantly lower in the calcaneal distraction group than in the cast immobilization group at various postoperative time points (P < 0.05). Ankle function scores were higher in the calcaneal distraction group than in the cast immobilization group at 12 months postoperatively (P < 0.05), indicating improved outcomes. Additionally, the SF-36 quality of life scores of patients undergoing calcaneal distraction were notably superior to those in the cast immobilization group.

Discussion

Calcaneal distraction is superior to cast immobilization in reducing soft tissue swelling, alleviating pain, and enhancing ankle function recovery in patients with Danis–Weber type C ankle fractures. Early calcaneal distraction upon hospital admission is recommended to optimize surgical outcomes.
Life’s building blocks: the modular path to multiscale complexity
Authors: Huitzil Saúl , Huepe Cristián
Published: July 2024

Modularity, the structuring of systems into discrete, interconnected units, is a fundamental organizing principle in biology across multiple scales. Recent progress in understanding the role of modularity as an evolutionary mechanism and a key driver of biological complexity has highlighted its importance in shaping the structure and function of living systems. Here, we propose a unifying framework that identifies the potential evolutionary advantages of modularity in systems ranging from molecular networks to ecologies, such as facilitating evolvability, enhancing robustness, improving information flows, and enabling the emergence of higher-level functions. Our analysis reveals the pervasiveness of modularity in living systems and highlights its crucial role in the evolution of multiscale hierarchies of increasing complexity.
What are the main proteins in the hemolymph of Haemaphysalis flava ticks?
Authors: Li Dan , Liu Lei , Liu Zi-ling , Tian Yuan , Gao Xin , Cheng Tian-yin
Published: July 2024

Background

Haemaphysalis flava is a notorious parasite for humans and animals worldwide. The organs of H. flava are bathed in hemolymph, which is a freely circulating fluid. Nutrients, immune factors, and waste can be transported to any part of the body via hemolymph. The main soluble components in hemolymph are proteins. However, knowledge of the H. flava proteome is limited.

Methods

The hemolymph was collected from fully engorged H. flava ticks by leg amputation. Hemolymph proteins were examined by both blue native polyacrylamide gel electrophoresis (BN-PAGE) and sodium dodecyl sulfate PAGE (SDS-PAGE). Proteins extracted from the gels were further identified by liquid chromatography–tandem mass spectrometry (LC–MS/MS).

Results

Two bands (380 and 520 kDa) were separated from tick hemolymph by BN-PAGE and were further separated into four bands (105, 120, 130, and 360 kDa) by SDS-PAGE. LC–MS/MS revealed that seven tick proteins and 13 host proteins were present in the four bands. These tick proteins mainly belonged to the vitellogenin (Vg) family and the α-macroglobulin family members. In silico structural analysis showed that these Vg family members all had common conserved domains, including the N-terminus lipid binding domain (LPD-N), the C-terminus von Willebrand type D domain (vWD), and the domain of unknown function (DUF). Additionally, two of the Vg family proteins were determined to belong to the carrier protein (CP) by analyzing the unique N-terminal amino acid sequences and the cleaving sites.

Conclusion

These findings suggest that the Vg family proteins and α-macroglobulin are the primary constituents of the hemolymph in the form of protein complexes. Our results provide a valuable resource for further functional investigations of H. flava hemolymph effectors and may be useful in tick management.
Life with pets study: lower income veterinary clients' perception of pets' quality of life
Authors: Strand Elizabeth B. , Scoresby Kristel , Walker Hannah , Hernandez Ana , Accornero Veronica , Messinger Lori , Linden Pamela , Ward Chesney , Knight Matthew P. , Engelman Haley , Moore Kristin , Slater Margaret Ruth
Published: July 2024

Perception of quality of life for cats and dogs of low-income Spanish and English-speaking veterinary clients attending problem focused or routine veterinary visits is an important area of focus for community based veterinary service providers. Using a qualitative approach, 50 New York City based American Society for the Prevention of Cruelty to Animals (ASPCA) veterinary clients completed semi-structured interviews as well as a survey about their perception of life with their pets. Veterinary clients shared both human-animal bond (HAB) related and quality of life (QoL) related factors in their daily experience of life with their pets. Results indicated that this demographic perceives QoL similarly to previous QoL research that either does not report sample demographics or reports sample demographics with more affluence. Moreover, 60% of qualitative excerpts included both HAB and QoL themes and 40% were discretely HAB or QoL. An analog single item 10-point scale measuring veterinary client perception of their pets QoL did not differentiate between sample demographics at a statistically significant level. Finally, pet QoL literature has not traditionally reflected diverse demographic identities of veterinary clients or widely included reliable and valid measures of the human-animal bond (HAB). These results support the importance of measuring the HAB when researching pet QoL and provide evidence that lower-income Spanish and English-speaking veterinary clients are similarly bonded and attentive to their pets as other demographics.
Strategic IT Alignment and Organizational Agility in Nonprofits during Crisis
Authors: Azevedo Lauren , Lee Roderick , Shi Wanzhu
Published: July 2024

As the study of nonprofit organizations and their operating environment has become increasingly interdisciplinary, scholars have leveraged business strategies to increase knowledge and improve performance. This study considers how strategic information technology alignment can impact organizational agility among nonprofits that are in the midst of the COVID-19 pandemic, a dynamic and complex crisis environment. Using a survey of United States-based nonprofits, we find that organizational alignment as well as aspects of financial stability significantly impact organizational agility. This study concludes with implications for nonprofits to broaden their participation in a digital society by developing their capacity to strategically plan, design, and implement strategic initiatives that align the organizational mission and assist with agility. Further, a broader discussion on the need to expand the definition of alignment in the context of nonprofit organizations is made, particularly in regard to new initiatives to include underrepresented groups and diverse voices in strategic initiatives.
Cooling of 1 MW Electric Motors through Submerged Oil Impinging Jets for Aeronautical Applications
Authors: Di Lorenzo Giuseppe , Romano Diego Giuseppe , Carozza Antonio , Pagano Antonio
Published: July 2024

Electrification of aircraft is a very challenging task as the demand for energy and power is high. While the storage and generation of electrical energy are widely studied due to the limited specific energy and specific power of batteries and fuel cells, electric machines (power electronics and motors) which have years of experience in many industrial fields must be improved when applied to aviation: they generally have a high efficiency but the increase in power levels determines significant thermal loads which, unlike internal combustion engines (ICE), cannot be rejected with the exhaust. There is therefore a need for thermal management systems (TMSs) with the main objective of maintaining operating temperatures below the maximum level required by electric machines. Turboprop aircraft, such as the ATR 72 or the Dash 8-Q400, are commonly used for regional transport and are equipped with two gas turbine engines whose combined power is in the order of 4 MW. Electric and hybrid propulsion systems for these aircraft are being studied by several leading commercial aviation industries and start-ups, and the 1MW motor size seems to be the main option as it could be used in different aircraft configurations, particularly those that exploit distributed electric propulsion. With reference to the topics mentioned above, the present work presents the design of a TMS for a high-power motor/generator whose electrical architecture is known. Once integrated with the electrical part, the TMS must allow a weight/power ratio of 14 kW/kg (or 20 kW/kg at peak power) while maintaining the temperature below the limit temperature with reasonable safety margins. Submerged jet oil is the cooling technique here applied with a focus on diathermic oil. Parameters affecting cooling, like rotor speed and filling factor, are analysed with advanced CFD.
The Optimal Supplementation of Fermented Product Produced by Bacillus subtilis Strain LYS1 with High Surfactin Yield for Improving Growth Performance, Intestinal Villi Morphology, and Tibial Bone Strength in Broilers
Authors: Lee Yueh-Sheng , Ku Kuo-Lung , Chu Chi-Shih , Chen Kuo-Lung
Published: July 2024

This study aimed to investigate the physiochemical characterizations of the fermented product (FP) produced by the high-yield surfactin strain Bacillus subtilis LYS1 (LYS1), as well as its effects on growth performance, carcass traits, intestinal morphology, tibial bone characteristics, and clinical blood biochemistry in broilers. Accordingly, the optimal supplementation of FP for improving growth performance, intestinal villi development, and tibial bone strength in broilers was elucidated using a broken-line quadratic (BLQ) ascending model. Three hundred and sixty 0-day-old Ross 308 broiler chicks, with equal numbers of both sexes, were randomly assigned to dietary supplementation of 2.5% fish meal or 0, 1, 1.5, 2, or 2.5% FP. Each treatment had six replicates, and the experimental period was 5 wk. The LYS1 count, surfactin content, and surfactin composition of the FP were 9.1 log CFU/g, 11.23 mg/g, and C12 to C18, respectively. The FP-supplemented groups improved feed intake, weight gain (WG), and production efficiency factor at 0 to 5 weeks old (p < 0.05) compared with the 0% group. The villus height/crypt depth (V/C) in the jejunum and ileum of the FP-supplemented groups was higher than in the 0% group (p < 0.05). The tibiotarsal index, Ca, and P in the tibia showed a linear effect with increased FP supplementation (p < 0.05). Moreover, the tibiotarsus weight/length index (TWLI) showed a quadratic effect with increased FP supplementation (p < 0.05). The optimal supplementation of FP for WG, V/C in the jejunum and ileum, and TWLI was 1.8, 1.9, and 1.6%, respectively. In conclusion, dietary supplementation with 1 to 2.5% LYS1 FP in broilers can improve their growth performance and the development of intestinal villi. Moreover, 1.9% is the optimal supplementation of LYS1 FP in the diet, based on the fitting results obtained with the BLQ model.
Postscript to Invertebrate Welfare: “We Have Met the Enemy and He Is Us”
Authors: Winlow William , Mather Jennifer , Cosmo Anna Di
Published: July 2024

Through this collection of papers, we have considered in depth the effects that humans have on invertebrate welfare in a variety of contexts [...]
1000 Animals Left Behind: Responder Experiences of the 2017 Edgecumbe Flood in New Zealand
Authors: Glassey Steve , Liebergreen Nicola , Ferrere Marcelo Rodriguez , King Mike
Published: July 2024

The 2017 Edgecumbe flood in New Zealand necessitated the rescue of over 1000 animals, making it the largest companion animal rescue operation in the nation’s history at the time. This qualitative study explores the experiences and perspectives of six first responders from various agencies involved in the animal rescue efforts. Through semi-structured interviews, this study identified several key themes, including challenges during the rescue phase, post-rescue issues, the impact on the human–animal relationship and wellbeing, and the health and safety of responders. The rescue phase was characterised by difficulties in evacuating and rescuing animals, the influence of the socio-zoological scale on rescue prioritisation, issues with feeding animals in place, and the diversity of species requiring rescue. Post-rescue challenges included animal identification and tracking, decontamination, management of deceased animals, and long-term impacts on animals and owners. This study also highlighted the interconnectedness of human and animal welfare during the disaster, as well as the health and safety risks faced by responders. The findings underscore the need for comprehensive collaborative emergency response planning that addresses the needs of both humans and animals, as well as the importance of ongoing efforts to build resilience and preparedness in communities. Lessons learned from the Edgecumbe flood can inform future policy, planning, and practice to enhance the effectiveness and compassion of animal-inclusive emergency management.
The Role of Play in the Social Development of Grey Seal (Halichoerus grypus) Pups with Comparative Notes on the Harbour Seal (Phoca vitulina)
Authors: Wilson Susan C.
Published: July 2024

Juvenile grey seals are known to be highly social, interacting with contact behaviours interpreted as gentle play. However, minimal sociality of pups with their mothers and among weaned pups has been suggested. The present study aimed to observe the natural social interactions of pups to track the early ontogeny of their sociality. Pup behaviour at a salt marsh colony on the east coast of England was video-recorded. Pups interacted with their mothers around suckling bouts and after weaning as they gathered around pools. The records were transcribed to spreadsheets in 30 s time segments to estimate the frequency and co-occurrence of different behaviours. Mother-pup interaction comprised nosing contacts and sometimes contact play, involving one laying the head and fore-flipper over the other. Initial weaned pup encounters involved tentative nosing and defensive splashing, indicating contact shyness. However, socially orientated locomotor play, supine posturing, and exaggerated raising of fore- and hind-flippers led to reduced shyness and pups following one another towards the sea. Archive data on subadult interactions and on harbour seal behaviours were re-analysed. Gentle play-like contact between mother–pup, juvenile, and adult pairs is interpreted here as a universal mode of social bonding, underscoring the social structure of both grey and harbour seals.
Adverse Events of PD-1, PD-L1, CTLA-4, and LAG-3 Immune Checkpoint Inhibitors: An Analysis of the FDA Adverse Events Database
Authors: Frey Connor , Etminan Mahyar
Published: July 2024

This study aimed to identify the 25 most prevalent adverse events (AEs) associated with FDA-approved immune checkpoint inhibitors (ICIs)—specifically, PD-1, PD-L1, CTLA-4, and LAG-3 inhibitors—using data from the FDA Adverse Events Reporting System (FAERS), a publicly available repository of reported drug adverse events, and AERSMine, an open-access pharmacovigilance tool, to investigate these adverse events. For PD-1 inhibitors, the most common AEs were diarrhea, fatigue, and pyrexia, with notable instances of neutropenia and hypothyroidism, particularly with toripalimab and dostarlimab. PD-L1 inhibitors also frequently caused pyrexia, diarrhea, and fatigue, with interstitial lung disease and hypothyroidism showing a class effect, and drug-specific AEs such as hepatotoxicity and chills. CTLA-4 inhibitors predominantly resulted in diarrhea and colitis, with ipilimumab frequently causing pyrexia and rash, while tremelimumab exhibited unique AEs such as biliary tract infection. The LAG-3 inhibitor relatlimab reported fewer AEs, including pyrexia and pneumonia. Rare but significant AEs across all inhibitors included myocarditis and myasthenia gravis. This study provides a detailed overview of the 25 most common AEs associated with ICIs, offering valuable insights for clinical decision-making and AE management. Further research is necessary to elucidate the mechanisms underlying these AEs and to develop targeted interventions to enhance the safety and efficacy of ICI therapy in patients with cancer.
Construction 4.0: A Systematic Review of Its Application in Developing Countries
Authors: Jaiswal Shubham V. , Hunt Dexter V. L. , Davies Richard J.
Published: July 2024

This study conducts a literature review to analyse the incorporation of Industry 4.0 in the construction sector, known as Construction 4.0, in developing countries. This study utilises an effective technique, encompassing academic databases, journals, and conference proceedings, to carefully examine relevant studies published with respect to developing countries. The primary areas of emphasis involve the definition of Construction 4.0. The technologies of execution include six cutting-edge technologies such as Building Information Modelling (BIM), Internet of Things (IoT), robotics, 3D printing, UAVs, and artificial intelligence in construction procedures. This analysis also explores the awareness and understanding of Industry 4.0 in the construction sector (Construction 4.0) in developing countries before identifying where it is being applied therein. Furthermore, obstacles that impede the mainstream adoption in developing countries are identified, including but not limited to such things as insufficient technological infrastructure, skill deficiencies, and budgetary limitations. This review consolidates various studies to provide a thorough comprehension of the present condition of Construction 4.0 in developing nations. As such, this paper aims to provide a guide for future research, policy making, and industry practices in order to promote sustainable and technologically advanced construction methods in these settings.
Innovative Approaches to Clinical Diagnosis: Transfer Learning in Facial Image Classification for Celiac Disease Identification
Authors: Keskin Bilgiç Elif , Zaim Gökbay İnci , Kayar Yusuf
Published: July 2024

Background: Celiac disease arises from gluten consumption and shares symptoms with other conditions, leading to delayed diagnoses. Untreated celiac disease heightens the risk of autoimmune disorders, neurological issues, and certain cancers like lymphoma while also impacting skin health due to intestinal disruptions. This study uses facial photos to distinguish individuals with celiac disease from those without. Surprisingly, there is a lack of research involving transfer learning for this purpose despite its benefits such as faster training, enhanced performance, and reduced overfitting. While numerous studies exist on endoscopic intestinal photo classification and a few have explored the link between facial morphology measurements and celiac disease, none have concentrated on diagnosing celiac disease through facial photo classification. Methods: This study sought to apply transfer learning techniques with VGG16 to address a gap in research by identifying distinct facial features that differentiate patients with celiac disease from healthy individuals. A dataset containing a total of 200 facial images of adult individuals with and without celiac condition was utilized. Half of the dataset had a ratio of 70% females to 30% males with celiac condition, and the rest had a ratio of 60% females to 40% males without celiac condition. Among those with celiac condition, 28 were newly diagnosed and 72 had been previously diagnosed, with 25 not adhering to a gluten-free diet and 47 partially adhering to such a diet. Results: Utilizing transfer learning, the model achieved a 73% accuracy in classifying the facial images of the patients during testing, with corresponding precision, recall, and F1 score values of 0.54, 0.56, and 0.52, respectively. The training process involved 50,178 parameters, showcasing the model’s efficacy in diagnostic image analysis. Conclusions: The model correctly classified approximately three-quarters of the test images. While this is a reasonable level of accuracy, it also suggests that there is room for improvement as the dataset contains images that are inherently difficult to classify even for humans. Increasing the proportion of newly diagnosed patients in the dataset and expanding the dataset size could notably improve the model’s efficacy. Despite being the first study in this field, further refinement holds promise for the development of a diagnostic tool for celiac disease using transfer learning in medical image analysis, addressing the lack of prior studies in this area.
Hydrogen from Depleted/Depleting Hydrocarbon Reservoirs: A Reservoir Engineering Perspective
Authors: Alkan Hakan , Bauer Johannes Fabian , Burachok Oleksandr , Kowollik Patrick , Olbricht Michael , Amro Mohd
Published: July 2024

In today’s industry, H2 is mostly produced from fossil fuels such as natural gas (NG), oil, and coal through various processes. However, all these processes produce both carbon dioxide (CO2) as well as H2, making them questionable in terms of climate change mitigation efforts. In addition to efforts to increase the conversion efficiency of green H2 technologies, work is also underway to make H2 production from fossil fuels more environmentally friendly by reducing/avoiding CO2 emissions. In this framework, these technologies are combined with geologic carbon storage. In a further step, the use of depleted hydrocarbon reservoirs for in situ H2 production is being investigated, with the co-generated CO2 remaining permanently in the reservoir. The objective of this paper is to provide a brief overview of the technologies that can be used to produce H2 from depleted and depleting hydrocarbon reservoirs (DHRs) in various ways. We evaluate the required processes from a reservoir engineering perspective, highlighting their potential for H2 generation and their technology readiness level (TRL) for applications. We also investigate the possibility of permanently storing the co-produced CO2 in the reservoir as a means of mitigating emissions. In addition, we provide a preliminary cost analysis to compare these methods with conventional hydrogen production techniques, as well as an assessment of operational risks and associated cost estimates.
Effect of Methylammonium Iodide (MACl) on MAPbI3-Based Perovskite UV-C Photodetectors
Authors: Shin Dong Jae , Kim Sangmo , Choi Hyung Wook
Published: July 2024

In this study, we fabricated deep ultraviolet (DUV) photodetectors based on perovskite thin films doped with halide materials using formamidinium bromide (FABr) and methylammonium iodide (MAI). The device was fabricated using a simple surface engineering technique by post-treating the MAPbI3 perovskite film with an FABr solution. This film acts as a light absorption layer, like a depletion layer with a p-i-n (PIN) structure, with n-type of SnO2-SDBS and p-type of spiro-OMeTAD. Adding 0.10 M MACl to the MAPbI3 precursor solution during the manufacturing process could effectively reduce the trap density compared with existing films. Films with MACl added in the two-step process can control a wide band gap and improve crystallinity. In addition, the Cl atom has a smaller atomic radius than iodine and a higher electronegativity of 3.16, which can improve phase stability, and the effect of the added Cl− increases the electron mobility of the perovskite, showing a fast response.
Southerly Surge Impact on Rainfall Patterns in Southern Indonesia during Winter Monsoon and Madden–Julian Oscillation (MJO)
Authors: Trismidianto  , Satiadi Didi , Harjupa Wendi , Fathrio Ibnu , Risyanto  , Saufina Elfira , Muharsyah Robi , Nuryanto Danang Eko , Nauval Fadli , Andarini Dita Fatria , Purwaningsih Anis , Harjana Teguh , Praja Alfan Sukmana , Witono Adi , Juaeni Ina , Suhandi Bambang
Published: July 2024

The impact of the southerly surge’s interaction with the MJO on rainfall in this study was investigated using daily rainfall data from 2140 weather-observation stations. The southern surge, which coincided with the MJO, enhanced rainfall in the western research region, with Yogyakarta seeing the greatest increase at 4.69 mm/day. Meanwhile, the southern surge that occurred without the MJO increased rainfall in the eastern region, with West Nusa Tenggara seeing the greatest rise at 3.09 mm/day. However, the southerly surge has the effect of lowering rainfall in Jakarta, reaching −2.21 mm/day when the MJO is active and −1.58 mm/day when the MJO is inactive. The southerly surge causes extreme rainfall to only occur in a small part of certain areas, so it tends to significantly reduce the possibility of extreme rainfall. In the southern part of the Indonesian maritime continent, the southerly surge predominates over the MJO, supporting increased water vapor transport. Rainfall mostly increases in the afternoon and decreases in the morning when the southerly surge occurs, whether there is the MJO or not. Convective instability analysis indicates that SS increases precipitation, most likely by raising vertically integrated moisture flux convergence, with a correlation coefficient value of 0.82.
Connection between Winter East Asia Flow Patterns and Stratospheric Polar Vortex Anomalies
Authors: Taguchi Masakazu
Published: July 2024

Using a reanalysis dataset, this work investigates the possible connection of winter East Asia (EA) flow patterns to stratospheric polar vortex (SPV) anomalies. Cluster analysis is performed on the principal components of daily 500 hPa geopotential height fields to identify five distinct flow patterns. SPV anomalies are considered in terms of the occurrence of major sudden stratospheric warmings (MSSWs). The results reveal that for the 15 days before the MSSWs, one of the five patterns occurs more frequently than usual, whereas another occurs less frequently. The former constructively interferes with the climatological EA trough in the troposphere and strengthens the planetary wave activity (heat flux) in the extratropical troposphere and stratosphere. It has a similar pattern in the 500 hPa height to the composite leading to the MSSWs, implying that such strengthening can contribute to the forcing of the MSSWs. The latter is in the opposite sense (destructive interference) and is disadvantageous before the MSSWs. Evidence of a stratospheric downward influence on the five flow patterns is relatively unclear. These results suggest a potential coupling between flow patterns or weather regimes in different regions through the SPV, as well as warrant further investigation of the downward influence on EA weather regimes.
Selective Separation of Lithium from Leachate of Spent Lithium-Ion Batteries by Zirconium Phosphate/Polyacrylonitrile Composite: Leaching and Sorption Behavior
Authors: Haruna Baffa , Luo Zhongyan , Muhammad Mujtaba Aminu , Tang Jinfeng , Kuva Jukka , Koivula Risto , Bao Hongli , Xu Junhua
Published: July 2024

This study introduces a straightforward and effective amorphous ZrP/polyacrylonitrile composite ion exchange method for separating Li from the leachate of spent Li-ion batteries (NMC 111). The cathode materials were leached with a series of optimized experiments. The influence of operating variables, including the H2SO4 concentration, temperature, H2O2 concentration, and pulp density, on leaching efficiency was examined to determine the optimal conditions for sorption experiments. The leaching efficiencies of Li, Co, Ni, and Mn were found to be 99.9%, 99.5%, 98.8%, and 99.9%, respectively. Subsequently, batch sorption experiments were performed by using am-ZrP/PAN, including the determination of the effect of pH, sorption kinetics, and the sorption isotherm. The effect of pH on adsorption was examined in 1 mmol/L equimolar solutions of Li, Ni, Mn, and Co. Li was separated from Mn, Co, and Ni in the leaching liquor. The adsorbent for Mn, Co, and Ni sorption better fitted pseudo-second-order kinetics. High selectivity for Li was observed, even at the higher solution concentration of 15 mM Li, Ni, Co and Mn. In addition, the column loading process demonstrated selectivity for Li over Co, Ni, and Mn metal ions. The preliminary evaluation of the whole process with mass flow demonstrated that it would be feasible to achieve full separation and metal recovery by integrating a combined hydrometallurgical method in future studies. However, much work is still needed to develop a practical separation flowsheet.
Evaluation of Denoising Performance of ResNet Deep Learning Model for Ultrasound Images Corresponding to Two Frequency Parameters
Authors: Kang Hyekyoung , Park Chanrok , Yang Hyungjin
Published: July 2024

Ultrasound imaging is widely used for accurate diagnosis due to its noninvasive nature and the absence of radiation exposure, which is achieved by controlling the scan frequency. In addition, Gaussian and speckle noises degrade image quality. To address this issue, filtering techniques are typically used in the spatial domain. Recently, deep learning models have been increasingly applied in the field of medical imaging. In this study, we evaluated the effectiveness of a convolutional neural network-based residual network (ResNet) deep learning model for noise reduction when Gaussian and speckle noises were present. We compared the results with those obtained from conventional filtering techniques. A dataset of 500 images was prepared, and Gaussian and speckle noises were added to create noisy input images. The dataset was divided into training, validation, and test sets in an 8:1:1 ratio. The ResNet deep learning model, comprising 16 residual blocks, was trained using optimized hyperparameters, including the learning rate, optimization function, and loss function. For quantitative analysis, we calculated the normalized noise power spectrum, peak signal-to-noise ratio, and root mean square error. Our findings showed that the ResNet deep learning model exhibited superior noise reduction performance to median, Wiener, and median-modified Wiener filter algorithms.
Fabrication and Dielectric Validation of an Arm Phantom for Electromyostimulation
Authors: Uhrhan Katja , Schwindt Esther , Witte Hartmut
Published: July 2024

Electromyostimulation (EMS) is an up-and-coming training method that demands further fundamental research regarding its safety and efficacy. To investigate the influence of different stimulation parameters, electrode positions and electrode sizes on the resulting voltage in the tissue, a tissue mimicking phantom is needed. Therefore, this study describes the fabrication of a hydrogel arm phantom for EMS applications with the tissue layers of skin, fat, blood and muscle. The phantom was dielectrically validated in the frequency range of 20 Hz to 100 Hz. We also conducted electromyography (EMG) recordings during EMS on the phantom and compared them with the same measurements on a human arm. The phantom reproduces the dielectric properties of the tissues with deviations ranging from 0.8% to more than 100%. Although we found it difficult to find a compromise between mimicking the permittivity and electrical conductivity at the same time, the EMS–EMG measurements showed similar waveforms (1.9–9.5% deviation) in the phantom and human. Our research contributes to the field of dielectric tissue phantoms, as it proposes a multilayer arm phantom for EMS applications. Consequently, the phantom can be used for initial EMS investigations, but future research should focus on further improving the dielectric properties.