bluuebunny/crossref_metadata_2025 huggingface dataset:
Admissions to psychiatric inpatient services and use of coercive measures in 2020 in a Swiss psychiatric department: An interrupted time-series analysis
Authors: Wullschleger Alexandre , Gonçalves Leonel , Royston Maya , Sentissi Othman , Ambrosetti Julia , Kaiser Stefan , Baggio Stéphanie
Published: July 2023

Background

The CoVID pandemic and the associated lockdown had a significant impact on mental health services. Inpatient services faced the challenge of offering acute psychiatric while implementing strict infection control measures. There is, however, a lack of studies investigating the use of coercive measures during the pandemic and their relation to hospitalizations and symptom severity.

Aims

To investigate the effects of the CoVID outbreak on psychiatric admissions, use of seclusion and symptom severity.

Method

Using routine data from 2019 and 2020 gathered in the Department of Psychiatry at the Geneva University Hospitals, we performed an interrupted time series analysis. This included the number of psychiatric hospitalizations, the proportion of people who experienced seclusion and the average severity of symptoms as measured by the Health of Nations Outcome Scale (HoNOS). Dependent variables were regressed on the time variable using regression model with bootstrapped standard errors.

Results

Hospitalizations decreased over time (b= -0.57, 95% CI: -0.67; -0.48,p< .001). A structural break in the data (supremum Wald test:p< .001) was observed in the 12thweek of 2020. There was an inverse relationship between the number of admissions and the proportions of people subject to seclusion (b= 0.21, 95% CI: -0.32; -0.09,p< .001). There was a statistically marginally significant inverse relationship between HoNOS scores at admission and the number of psychiatric hospitalizations (b= -1.28, 95% CI: -2.59, 0.02,p= .054).

Conclusion

Our results show that the CoVID pandemic in 2020 was associated with a significant decrease in the number of hospital admissions. This decrease was correlated with a greater use of seclusion. The higher burden of symptoms and the difficult implementation of infection control measures might explain this higher use of coercion.
They are not all the same: Determinants of attendance across different sectors in a stadium
Authors: Barajas Angel , Gasparetto Thadeu
Published: July 2023

Previous research inspecting the demand for tickets for professional sports has mostly used aggregate data in their estimations. In a nutshell, it implies that all fans would be driven by the same determinants. In this research, we test whether this hypothesis holds. We analyse all first-tier Brazilian League home matches of bothFlamengoandFluminenseat the iconic stadiumMaracanã(Brazil) from 2014 to 2019. Ordinary Least Square regressions model individual equations for each sector for comparing their determinants. Our empirical results offer evidence that ticket price and Uncertainty of Outcome have different impact on demand for tickets according to the sector. Further research is encouraged to inspect whether similar behavior is detected in other settings.
Reverse-zoonoses of 2009 H1N1 pandemic influenza A viruses and evolution in United States swine results in viruses with zoonotic potential
Authors: Markin Alexey , Ciacci Zanella Giovana , Arendsee Zebulun W. , Zhang Jianqiang , Krueger Karen M. , Gauger Phillip C. , Vincent Baker Amy L. , Anderson Tavis K.
Published: July 2023

The 2009 H1N1 pandemic (pdm09) lineage of influenza A virus (IAV) crosses interspecies barriers with frequent human-to-swine spillovers each year. These spillovers reassort and drift within swine populations, leading to genetically and antigenically novel IAV that represent a zoonotic threat. We quantified interspecies transmission of the pdm09 lineage, persistence in swine, and identified how evolution in swine impacted zoonotic risk. Human and swine pdm09 case counts between 2010 and 2020 were correlated and human pdm09 burden and circulation directly impacted the detection of pdm09 in pigs. However, there was a relative absence of pdm09 circulation in humans during the 2020–21 season that was not reflected in swine. During the 2020–21 season, most swine pdm09 detections originated from human-to-swine spillovers from the 2018–19 and 2019–20 seasons that persisted in swine. We identified contemporary swine pdm09 representatives of each persistent spillover and quantified cross-reactivity between human seasonal H1 vaccine strains and the swine strains using a panel of monovalent ferret antisera in hemagglutination inhibition (HI) assays. The swine pdm09s had variable antigenic reactivity to vaccine antisera, but each swine pdm09 clade exhibited significant reduction in cross-reactivity to one or more of the human seasonal vaccine strains. Further supporting zoonotic risk, we showed phylogenetic evidence for 17 swine-to-human transmission events of pdm09 from 2010 to 2021, 11 of which were not previously classified as variants, with each of the zoonotic cases associated with persistent circulation of pdm09 in pigs. These data demonstrate that reverse-zoonoses and evolution of pdm09 in swine results in viruses that are capable of zoonotic transmission and represent a potential pandemic threat.
Influenza A virus inhibits TET2 expression by endoribonuclease PA-X to attenuate type I interferon signaling and promote viral replication
Authors: Hu Yixiang , Chen Xinru , Ling Yuehuan , Zhou Kun , Han Meiqing , Wang Xingbo , Yue Min , Li Yan
Published: July 2023

Influenza A virus (IAV) expresses several accessory proteins to limit host anti-viral restriction factors to facilitate viral replication. The Ten-Eleven Translocation 2 (TET2) is a methylcytosine dioxygenase that promotes DNA demethylation by catalyzing the oxidation of 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), which plays a vital role in hematopoiesis and immunity. Here we report that TET2 is a host restriction factor that limits IAV replication. But IAV endoribonuclease PA-X is able to remove the replication restriction by binding to TET2 mRNA and driving TET2 mRNA degradation to reduce TET2 expression during infection. Genetic inactivation of TET2 markedly enhances IAV replication in vitro and in vivo. Mechanistically, we found that TET2 regulates demethylation and transcription of STAT1 and some interferon-stimulated genes (ISGs), including ISG15, ISG20, and IFIT5, so the loss of TET2 greatly impairs type I Interferon signaling. Furthermore, we confirmed that TET2-mediated demethylation of the STAT1 gene is critical for interferon anti-viral activity. Our study demonstrates that the host TET2 is essential to the innate immune response against IAV infection.
Acyloxyacyl hydrolase promotes pulmonary defense by preventing alveolar macrophage tolerance
Authors: Cheng Xiaofang , Jiang Wei , Chen Yeying , Zou Benkun , Wang Zhiyan , Gan Lu , Xiao Zeling , Li Changshun , Yu Cheng-Yun , Lu Yimeng , Han Zeyao , Zeng Jiashun , Gu Jie , Chu Tianqing , Fu Mingsheng , Chu Yiwei , Zhang Wenhong , Tang Jianguo , Lu Mingfang
Published: July 2023

Although alveolar macrophages (AMs) play important roles in preventing and eliminating pulmonary infections, little is known about their regulation in healthy animals. Since exposure to LPS often renders cells hyporesponsive to subsequent LPS exposures (“tolerant”), we tested the hypothesis that LPS produced in the intestine reaches the lungs and stimulates AMs, rendering them tolerant. We found that resting AMs were more likely to be tolerant in mice lacking acyloxyacyl hydrolase (AOAH), the host lipase that degrades and inactivates LPS; isolated Aoah-/- AMs were less responsive to LPS stimulation and less phagocytic than were Aoah+/+ AMs. Upon innate stimulation in the airways, Aoah-/- mice had reduced epithelium- and macrophage-derived chemokine/cytokine production. Aoah-/- mice also developed greater and more prolonged loss of body weight and higher bacterial burdens after pulmonary challenge with Pseudomonas aeruginosa than did wildtype mice. We also found that bloodborne or intrarectally-administered LPS desensitized (“tolerized”) AMs while antimicrobial drug treatment that reduced intestinal commensal Gram-negative bacterial abundance largely restored the innate responsiveness of Aoah-/- AMs. Confirming the role of LPS stimulation, the absence of TLR4 prevented Aoah-/- AM tolerance. We conclude that commensal LPSs may stimulate and desensitize (tolerize) alveolar macrophages in a TLR4-dependent manner and compromise pulmonary immunity. By inactivating LPS in the intestine, AOAH promotes antibacterial host defenses in the lung.
Responding to the global challenges of ‘Too Much, Too Little and Too Dirty’ Water: Towards a Safer and More Just Water Future
Authors: Grafton R. Quentin , Fanaian Safa
Published: July 2023

The world water crisis is manifest through ‘Too Much, Too Little and Too Dirty’ water at multiple scales from the local to the global. Understanding the key drivers and consequences of this water crisis, and who bears the biggest costs, is necessary to develop appropriate responses, at scale and over time. Using four framings: one, water stocks and limits; two, water rights and responsibilities; three, water values and prices; and four, green and grey water infrastructure, we review the challenges and possible responses. Using a water justice lens, we highlight the transitional and transformational pathways towards a safer and more just water future.
Capital Intangível e Produtividade das Empresas Portuguesas na Última Década (2010-2019)
Authors: Gonçalves Nuno , Carreira Carlos
Published: July 2023

This article analyzes the effects of intangible capital on the productivity of Portuguese firms in the last decade. Intangible assets can increase the productivity of labor and productive factors. Although no consensus has been reached on standard principles and uniform methods for measuring intangible assets, the attempts of various investigators, such as those proposed in this research, pave the way for the development of a framework. To achieve this objective, a Cobb-Douglas production function was estimated at the firm level, where intangible capital is assumed as a productive factor. To perform a sectoral analysis, the model was estimated by activity sector. We also estimated the evolution of the contribution of intangible capital in two distinct periods 2010-14 (recession) and 2015-19 (recovery). The results obtained were to some extent expected, confirming the evidence of the positive effect of intangible assets on productivity. The intangible effect is greater in the sectors of Manufacturing and Construction, and inside the Manufacturing sector, the Textile industry is where the effect is larger. For the Trade and Business Services sector the effect is negative or null. Although intangible capital has a strong influence at the aggregate level, it has gradually lost its relevance. This result is understandable, given the low and decreasing levels of intangible investment and the continuous decrease in intangible capital during the decade.
Influence of microbiota inoculum as a substitute for antibiotic growth promoter during the initial laying phase on productivity performance, egg quality, and the morphology of reproductive organs in laying hens
Authors: Agustono Bodhi , Warsito Sunaryo Hadi , Yunita Maya Nurwartanti , Lokapirnasari Widya Paramita , Hidanah Sri , Sabdoningrum Emy Koestanti , Al-Arif Mohammad Anam , Lamid Mirni , Yuliani Gandul Atik , Chhetri Shekhar , Windria Sarasati
Published: July 2023

Background and Aim: Antibiotics that increase growth have long been employed as a component of chicken growth. Long-term, unchecked usage may lead to microbial imbalance, resistance, and immune system suppression. Probiotics are a suitable and secure feed additive that may be provided as a solution. The objective of this research was to ascertain the effects of dietary multistrain probiotics (Lactobacillus acidophilus, Bifidobacterium spp., and Lactobacillus plantarum) on the morphology (length and weight) of reproductive organs and productivity performance of laying hens during the early stage of laying.

Materials and Methods: One hundred ISA Brown commercial layer chicks of the same body weight (BW) that were 5 days old were divided into five treatments, each with four replicates and four chicks in each duplicate. There were five different dietary interventions: (T1) 100% base feed; (T2) base feed with 2.5 g of antibiotic growth promoter/kg feed; (T3) base feed plus probiotics; (T4) base feed at 1 mL/kg with probiotics; and (T5) base feed with probiotics, 3 mL/kg feed, 5 mL/kg of feed. The parameters observed were performance, internal and exterior egg quality, and the morphology (length and weight) of laying hens’ reproductive organs.

Results: Probiotic supplementation (L. acidophilus, Bifidobacterium, and L. plantarum) significantly affected the BW, feed intake, egg weight, yolk index, albumin index, Haugh unit, egg height, egg width, and morphology (length and weight) of laying hens’ reproductive organs compared to the control group (basic feed). In addition, there was no discernible difference between treatment groups in theeggshell weight and thickness variables across all treatment groups.

Conclusion: When laying hens were between 17 and 21 weeks old, during the early laying period, microbiota inoculum supplements (L. acidophilus, Bifidobacterium, and L. plantarum) increased growth, the quality of the internal and external layers’ eggs, and the morphology of the laying hens’ reproductive organs.

Keywords: external quality eggs, good health, growth performance, internal quality eggs, probiotics, reproductive organs.
L’EVOLUCIÓ DE LA DESIGUALTAT A ESPANYA I DINAMARCA EN LA GRAN RECESSIÓ: QUINA INFLUÈNCIA HI TENEN ELS MODELS LABORALS?
Authors: Exposito Estrada Marc
Published: July 2023

La crisi econòmica i financera de 2008 ha esdevingut una de les recessions més importants de la història moderna. Normalment, alhora de valorar quin ha estat l’impacte d’aquesta crisi ens fixem en quina ha esdevingut la seva influència en els indicadors macroeconòmics. Sabem que en aquest sentit va tenir un gran impacte a Espanya i també que va afectar molt diferent als diversos països de la Unió Europea.Encara que els indicadors econòmics són importants, també es considera rellevant quin ha estat l’impacte en els nivells de desigualtat. Per això, en aquest treball es pretén analitzar l’evolució durant el que portem de segle XXI i quines han esdevingut les conseqüències en els nivells de desigualtat a la societat espanyola al llarg i posteriorment a la crisi. Així mateix, existeixliteratura que estableix hi ha una relació entre el model laboral d'un país i els nivells d'atur i desigualtat. Per comprovar aquesta relació, es realitza una comparació de diversos indicadors del mercat de treballi nivells de desigualtat entre Espanya i Dinamarca, un país amb un model laboral considerat d'èxit a nivell internacional.
Acciones colectivas y resistencias frente a la inseguridad alimentaria durante la pandemia de la COVID-19
Authors: Zúñiga Olivares Miguel Armando , Fernández Obregón Daniel Gilbert
Published: July 2023

Con la llegada de la pandemia de la COVID-19 al Perú, se dio un aumento rápido de la inseguridad alimentaria, debido a los efectos económicos y sociales de la pandemia y los efectos no deseados derivados del Estado de Emergencia Nacional. Ante la respuesta tardía e insuficiente del Estado, las ollas comunes (OC) resurgieron en forma inmediata, como acciones colectivas y solidarias para recolectar, preparar y distribuir raciones de alimentos a las familias más vulnerables. A partir de su participación en instancias de gobernanza de la Municipalidad Metropolitana de Lima, las OC crearon la Red de OC de Lima Metropolitana, como instancia de conducción y coordinación. A través de esta Red, las OC realizaron incidencia política para su registro y la entrega de alimentos del Estado, y control social para la adecuada implementación de dichos procesos. A mediados del 2021, la Red, su equipo técnico y sus aliadas políticas se consolidaron como una coalición de incidencia política, logrando la aprobación de leyes y decretos sobre seguridad alimentaria y nutricional, y su financiamiento. No obstante, casi siempre hubo resistencia del Estado a la participación de las OC en el proceso de elaboración de políticas públicas, algunas leyes no fueron reglamentadas y el financiamiento fue insuficiente para garantizar su sostenibilidad. Actualmente, existen 3.364 OC registradas, en 14 departamentos (incluyendo Lima Metropolitana) y Callao, con 229.072 beneficiarias. Su agenda política no sólo ha incluido la garantía del presupuesto público alimentario, sino también políticas de recuperación de alimentos, alimentación saludable y agricultura familiar. Ante la persistencia de las condiciones para una crisis alimentaria de larga data a nivel mundial, y particularmente en América Latina y el Caribe, las OC podrían consolidarse como prácticas de resistencia frente al hambre, espacios de discusión y reflexión crítica y de movilización social.
The Development of Integrated Science Process Skills Test in Research and Knowledge Formation the Lower Secondary Students
Authors:   Major of Educational Research Measurement and Statistics, Department of Research and Applied Psychology, Faculty of Education Burapha University, Thepjit Thiranun , Anussasananan Sureeporn ,   Assistant Professor Dr., Department of Research and Applied Psychology, Faculty of Education Burapha University., Ngammeerith Natkrita ,   Dr., Department of Research and Applied Psychology, Faculty of Education Burapha University.
Published: July 2023

The purposes of this research is to: 1) to create an integrated science process skill test, in Research and Knowledge Formation for lower secondary students. 2) to examine the quality of the integrated science process skill test scale and 3) to find a cut-off score and create a manual for using the integrated science process skill measurement in research and knowledge formation for lower secondary students. The sample group in this research was a 950 lower secondary students in the world-class International standard school under the Secondary Educational Service Area Office 17 in 2nd semester, academic year 2018, selected by simple random sampling technique. The instrument used in the research was the multiple choice with 4 options for 40 items. The results of this research were as follow: the content validity of integrated science process skill measurement test was at a good quality whit the Index of Item-Objective Congruence (IOC) was at .67-1.00, the item difficulty was between .30-.80, the item discrimination was between .20-.67, the reliability of the test was at .93. The concurrent validity by Pearson’s correlation coefficient was .88 and structural straightness found that the model of integrated science process skills measurement test in research and knowledge creation agreed with empirical data. The Chi-square 1067.39, (p = .00), RMSEA = .033, GFI = .91, AGFI = .90, CFI = .99 and RMR = .009. The cut-off score of the integrated science process skill test scale in research and knowledge formation for lower secondary students, based on Angkoff's method of scoring cut points was at 23 points out of 40 full points.
Knowledge and Consumption Behavior of Students’ Ramkhamhaeng	University Demonstration School
Authors:   Instructor, The Demonstration School of Ramkhamhaeng University, Faculty of Education,  Ramkhamhaeng University, Thamdee Onuma
Published: July 2023

The objectives of this research were to study knowledge and food consumption behavior of students’ Ramkhamhaeng Demonstration School and to compare personal factors toward food consumption behavior students’ Ramkhamhaeng University Demonstration School. The questionnaire was used as a research tool.Research samples was collecting from 213 students. Data analysis employed frequency, percentage, average, standard deviation, and t-Test dependent. The results were as follows: the most students were knowledgeable about eating sweet and fatty foods, risk of overweight and sausage was a high fat. Food consumption behavior of students was at high level Hypothesis testing was found that difference gender and education had behavior food consumption was no significant.
Learning Management with STEM Education Approach on Learning Achievement and Science Creative Thinking of Ninth Grade Students.
Authors:   Master of Education Program in Science Teaching Faculty of Education Burapha University, Tannawannapong Nattapong , Chaiprasert Pattaraporn ,   Faculty of Education Department of Learning Management Faculty of Education Burapha University, Singlop Somsiri ,   Faculty of Education Department of Learning Management Faculty of Education Burapha University, Wattanachod Kongsak ,   Assistant Professor Demonstration School "Piboonbamphen" Burapha University
Published: July 2023

The purposes of this research were to compare learning achievement and science creative thinking before and after learning, and to compare learning achievement after learning with criterion of 70 percent using STEM education approach. The participants were 28 ninth grade students from Piboonbumpen Demonstration School, Burapha University, who studied in the first semester of academic year 2018. They were selected by cluster random sampling. The research instruments were 1) lesson plans 2) learning achievement test and 3) science creative thinking test. The collected data were analyzed by arithmetic mean, percentage, standard deviation, and t-test. The research findings were as follows 1) The post-test scores of science learning achievement of the ninth grade students after learning with STEM education were higher than those before learning at the .05 significant level. 2) The post-test scores of science learning achievement of the ninth grade students after learning with STEM education were higher than 70 % set criterion at the .05 significant level. 3) The science creative thinking of the ninth grade students after learning with STEM education were higher than those before learning at the .05 significant level.
Daniel, Florio, and the Stationers
Authors: Pitcher John
Published: July 2023

This essay is concerned with the printed texts of two of Sir Philip Sidney’s books: the sonnet sequence Astrophel and Stella,published by the stationer Thomas Newman in 1591, and An Apologie for Poetrie, published by the stationer Henry Olney in 1595. While the current scholarly consensus is that Newman’s Astrophel and Stella was a “pirated” text, “suppressed” when the social elite (headed by Lord Burghley) intervened to prevent the book’s being read, the present essay challenges this interpretation through a new reading of the material record that offers a fuller account of the publication histories of both sets of sonnets, and of the origins of Olney’s publication.
Hubungan Kepatuhan Menjalani Terapi Hemodialisis dengan Kualitas Hidup Pasien Penyakit Ginjal Kronik di Masa Pandemi Covid-19
Authors: Susantri Wella , Bayhakki Bayhakki , Woferst Rismadefi
Published: July 2023

Introduction : The COVID-19 pandemic became one of the highest causes of death in early 2020. The spread is so fast and uncontrollable that it is the reason for many people to stay at home and avoid places with the highest spread, one of which is the hospital. In this condition, many people delay treatment, choose alternatives, and decide to no longer be in the hospital environment. This also applies to patients with chronic kidney failure, where sufferers are required to continue to take therapy to achieve a good quality of life. However, with the COVID-19 situation, most sufferers postpone therapy so they don't get infected. Compliance with therapy is very important for people with CKD to be able to achieve a good quality of life. This study aims to determine the relationship between compliance with hemodialysis therapy and the quality of life of CKD patients undergoing hemodialysis therapy during the COVID-19 period. Method: The research design used is descriptive correlational with a cross sectional approach. The sample in this study was a total sampling of 70 respondents. This study used the KDQL questionnaire to measure quality of life and The End-Stage Renal Disease Adherence Questionnaire (ESRD-AQ) questionnaire to measure adherence. The analysis used was bivariate analysis using the chi-square test. Results: Iit was found that 71.4% adhered to hemodialysis therapy and, 54.3% have a good quality of life. The statistical test results showed that there was a significant relationship between adherence to hemodialysis therapy and the quality of life of CKD patients where the p-value was 0.026 < α (0.05). Conclusion: There is a significant relationship between adherence and quality of life of CKD patients undergoing hemodialysis therapy. Nurses have an important role in motivating CKD patients to comply with hemodialysis therapy.Keywords: Hemodialysis Therapy, Adherence, Quality of Life, Chronic Kidney Disease.
Docosahexaenoic Acid Reverses Epithelial-Mesenchymal Transition and Drug Resistance by Impairing the PI3K/AKT/Nrf2/GPX4 Signalling Pathway in Docetaxel-Resistant PC3 Prostate Cancer Cells
Authors: Shao Z. C. , Zhu B. H. , Huang A. F. , Su M. Q. , An L. J. , Wu Z. P. , Jiang Y. J. , Guo H. , Han X.-Q. , Liu Chi-Ming
Published: July 2023

Drug resistance is a serious problem in cancer therapy. Growing evidence has shown that docosahexaenoic acid has anti-inflammatory and chemopreventive abilities. Studies have shown that autophagy inhibition and ferroptosis are promising therapeutic strategies for overcoming multidrug resistance. This study was aimed to examine whether docosahexaenoic acid (DHA) could reverse docetaxel resistance in prostate cancer cells. Cell survival was examined by MTT and colony formation. Protein expression was determined by Western blot. Reactive oxygen species (ROS) production was measured by flow cytometry. DHA displayed anti-cancer effects on proliferation, colony formation, migration, apoptosis, autophagy and epithelial mesenchymal transition. Glutathione-S-transferase π is an enzyme that plays an important role in drug resistance. DHA inhibited GSTπ protein expression and induced cytoprotective autophagy by regulating the PI3K/AKT signalling pathway in PC3R cells. DHA combined with PI3K inhibitor (LY294002) enhanced apoptosis by alleviating the expression of LC3B, (pro-) caspase-3 and (uncleaved) PARP. DHA induced ferroptosis by attenuating the expression of glutathione peroxidase 4 (GPX4) and nuclear erythroid 2-related factor 2 (Nrf2). DHA-treated PC3R cells produced ROS. The ROS and cytotoxicity were reversed by treatment with ferrostatin-1. DHA combined with docetaxel inhibited EMT by regulating the expression of E-cadhein and N-cadherin. In summary, DHA reversed drug resistance and induced cytoprotective autophagy and ferroptosis by regulating the PI3K/AKT/Nrf2/GPX4 signalling pathway in PC3R cells. We propose that DHA could be developed as a chemosensitizer and that the PI3K/AKT/Nrf2/GPX4 signalling pathway might be a promising therapeutic target for overcoming cancer drug resistance.
TRPM7 Elicits Proliferation and Differentiation of Human Lens Epithelial Cells through the TGF-β/Smad Pathways
Authors: Yang G. , Wu Y. , Tang Shaohua
Published: July 2023

Epithelial-mesenchymal transition (EMT) plays a crucial role in the development of cataract. This study aimed to explore the effects of TRPM7 on the proliferation and differentiation of human lens epithelial cells. TRPM7 was over-expressed in LECs treated with TGF-β2. Down-regulation of TRPM7 attenuated the increase in cell viability and cell proliferation induced by TGF-β2. The LEC migration induced by TGF-β2 was also repressed by down-regulation of TRPM7. Epithelial-specific protein E-cadherin was up-regulated through knock-down of TRPM7. EMT-specific proteins, α-SMA, fibronectin and vimentin, were down-regulated through knockdown of TRPM7. Moreover, phosphorylation of Smad2 and Smad3 was also prevented by inhibition of TRPM7. Therefore, TRPM7 elicited LEC proliferation and EMT through enhancing activation of the TGF-β/Smad pathways, implying a new therapeutic target for cataract.
Complications associated with the treatment of chronic limb-threatening ischemia
Authors: Vykhtiuk Т. І. , Orel Yu. H. , Slabyi O. M. , Khorkavyi Yu. Z. , Orel H. Yu. , Savchenko A. A.
Published: July 2023

The aim of the work is to review current national and foreign specialized literature on various complications associated with the treatment of chronic limb-threatening ischemia.
Atherosclerotic lesion of the lower limb arteries is the most common cause of tissue perfusion deficiency of the lower limbs and can lead to their loss. A radical method of treatment for chronic limb-threatening ischemia (CLTI) remains revascularization. Despite the modern possibilities of surgical treatment and many years of experience in such treatment, the percentage of surgical complications is still substantial.
The level of providing qualitative care to patients with CLTI consists in the successful correction of the mentioned complications. That is why the analysis of this problem is an urgent issue of modern angiosurgery.
Conclusions. Most complications after surgical treatment of atherosclerotic lower limb lesions could cause both a limb loss and a severe systemic disorder development in general. The presented data of the professional literature review of clinical and experimental studies justify the need for an early management of complications associated with surgical treatment of chronic limb-threatening ischemia. It would contribute not only to the limb preservation, but also prevent the occurrence of severe general somatic complications.
Is it possible to discontinue glucocorticoids in rheumatoid arthritis with the use of synthetic disease-modifying antirheumatic drugs?
Authors: Iaremenko O. B. , Mykytenko H. M.
Published: July 2023

The aim of the work is to study the possibility of glucocorticoid (GC) discontinuation or their target dose achievement in patients (pts) with rheumatoid arthritis (RA) receiving conventional synthetic disease-modifying antirheumatic drugs (DMARDs).
Materials and methods. 270 pts with RA (women – 86.6 %) aged 51.2 ± 0.71 years, with a disease duration of 50.20 ± 3.82 months were examined. Rheumatoid factor was found in 64.8 % of individuals, anti-cyclic citrullinated peptide (ACCP) antibodies – in 66.6 %. DMARD therapy included methotrexate (n = 91), leflunomide (n = 95), sulfasalazine (n = 51), hydroxychloroquine (n = 3) or its combination (n = 126). The SPSS (version 22.0) software was used for the statistical analysis.
Results. During the 3-year study, GC was withdrawn in 33 % of pts in the period from 3 to 30 months (mostly in the first 6 moths). Among those who continued to take GC, the target dose (<7.5 mg/d) was achieved only in 32.6 % of pts. Among pts continuously receiving GC, compared with pts who discontinued GC therapy, there were significantly more women (89.5 % vs. 80.8 %), ACCP-positive pts (88.4 % vs. 55.0 %), with higher DAS-ESR values (5.29 ± 0.10 vs. 4.84 ± 0.15) and more pronounced structural changes on the SHS scale (43.40 ± 2.42 vs. 32.40 ± 2.71).
According to the logistic regression analysis, female sex (OR 2.39), elderly pts (OR 1.02), ACCP-positivity (OR 3.73), disease activity by DAS-ESR (OR 1.19) and structural joint changes (OR 1.01) were significantly associated with the risk of continuing GC treatment. Only the initial dose of GC ≥7.5 mg/d was associated with the inability to reach the target dose of GC during the entire follow-up period (OR 6.32).
Conclusions. Despite of the treatment with conventional synthetic DMARD, only a third of RA pts can withdraw GC, mostly in the first 6 months. For the pts who continue taking GC, the target dose can be achieved in 33 % of them. Independent predictors of the impossibility to withdraw GC are female sex, old age, ACCP-positivity, higher RA activity according to DAS-ESR and more pronounced joint destruction in early stages. An initial GC dose ≥7.5 mg/d is a negative prognostic factor in achieving the target dose.
Effects of combination antihypertensive therapy on intracardiac hemodynamics and blood vessels in patients with coronary heart disease, post-infarction cardiosclerosis and arterial hypertension
Authors: Dolzhenko M. M. , Bondarchuk S. A. , Lobach L. Ye.
Published: July 2023

The aim of the work is to assess the effectiveness of prescribing a fixed-dose combination of amlodipine with the ACE inhibitor lisinopril or with the angiotensin 2 receptor blocker valsartan in patients with coronary artery disease, acute coronary syndrome with hypertensive disease regarding the impact on the structural and functional parameters of the heart and extracranial branches of the brachiocephalic arteries.
Materials and methods. General clinical examination of 108 patients with postinfarction cardiosclerosis and hypertension was done within 12 months. The patients were allocated to two groups. Patients in the first group (n = 50) were assigned a fixed-dose combination of lisinopril and amlodipine (20 mg and 5 mg, respectively), and patients in the second group (n = 58) received a fixed-dose combination of valsartan with amlodipine (160 mg and 5 mg, respectively). The patients were monitored for 12 months, including general clinical examinations, measurements of office blood pressure (BP), 24-hour BP monitoring, echo-dopplerographic examination of the heart and brachiocephalic arteries, determination of the composite endpoint. Statistical analysis of the obtained data was performed using Microsoft Excel, IBM SPSS Statistics v.23.
Results. A significant difference in echocardiographic data has been proved (p < 0.05) regarding left ventricle (LV) dimensions in both study groups. A significant decrease in the E/A ratio and an insignificant decrease in E/E’ (p > 0.05) have been found in the first group. When analyzing the indicators of diastolic function in the second group, a highly significant (p < 0.05) decrease in E/A, E/E’, IO of the LA has been revealed; data analysis on the morphofunctional state indicators of the extracranial arteries has shown a CIM reduction and a decrease in PSV and RI.
Conclusions. Prescriptions of the fixed-dose combination of amlodipine with the ACE inhibitor lisinopril was more effective in terms of the LV measurements (p < 0.05) and LV diastolic function as evidenced by decreased E/A, E/E’ and IO of the LA (p < 0.05) as compared to the data in the group of amlodipine with the angiotensin 2 receptor blocker valsartan. Both fixed-dose combinations were effective in reducing the CIM thickness, decreasing PSV and RI when analyzing the morphofunctional state findings of the extracranial arteries.
Krajobraz wielu zmysłów na przykładzie parków kieszonkowych w Krakowie
Authors: Sołtysik Anna
Published: July 2023

Artykuł ma na celu ukazanie parków kieszonkowych, utworzonych do tej pory w Krakowie, pod kątem aspektów związanych z ich odbiorem zmysłowym. Oprócz projektu zagospodarowania poszczególnych parków, ich wyposażenia w małą architekturę, nawierzchnie i roślinność, zostanie przeanalizowany ich potencjalny odbiór zmysłowy. Bardziej szczegółowej analizie zostanie poddany krajobraz dźwiękowy wybranych przykładów. Temat ten wiąże się z aspektami społecznymi w odbiorze krajobrazu. Służy także ukazaniu, jak poprzez umożliwienie percepcji wielozmysłowej możemy poprawić jakość przestrzeni miejskiej.
Educational intervention promotes injury prevention adherence in club collegiate men’s lacrosse athletes
Authors: Gawrys Steven P. , Wong Westin J. , Parker Lawsen M. , Bradshaw Justin T. , Starr Evan G. , Wilde Ben
Published: July 2023

Context

Club sports are intercollegiate athletics that are student-led and not university-funded, many of which are without professional credentialing. Collegiate club athletes have an increased rate of injury compared to their NCAA counterparts. Education and implementation of stretching and strength training have demonstrated decreased rates of noncontact injuries.

Objectives

Educational intervention was given to club collegiate athletes to determine its effect on injury rates, perceived pain, and compliance toward injury-prevention practices.

Methods

Intramural collegiate athletes were educated on injury prevention that focused on targeted stretching. Surveys designed to assess the impact of the education were distributed to three men’s club lacrosse teams in Utah at the beginning and end of the season. The questions measured pain and time missed due to noncontact injury.

Results

Two-tailed unpaired t tests demonstrated p values <0.05 for: overall decreased levels of pain (p<0.0001); increased range of motion (ROM, p<0.0001); increased frequency of stretching the muscle groups psoas (p<0.0001), calves (p=0.0081), and piriformis (p<0.0001); decreased pain levels for the hamstring (p=0.0274); and increased frequency of stretching after practice (p<0.0001).

Conclusions

The increased frequency of stretching suggests increased compliance toward injury prevention practices. Decreased self-reported levels of overall pain, and decreased pain in the hamstring, show that the subjects surveyed in the sample reported less pain and increased time stretching at the end of the season compared with the beginning of the season. Educational intervention offers an affordable measure to provide club collegiate athletes with resources to reduce injury rates through athlete compliance to targeted stretches.
Pre-treatment predictors of cardiac dose exposure in left-sided breast cancer radiotherapy patients after breast conserving surgery
Authors: Xu Lixia , Wang Hui , Wang Jiahao , Ren Yao , Zhang Lidan , Deng Wenfan , Li Xiadong
Published: July 2023

Objectives

This study aimed to identify high-risk factors for high cardiac radiation exposure, based on anatomical measurements taken from planning CT images of patients with left-sided breast cancer who underwent breast-conserving surgery and received radiotherapy.

Methods

We retrospectively analyzed 45 patients with left-sided breast cancer who underwent whole-breast radiotherapy, either under free breathing (27/45) or deep inspiratory breath-holding (DIBH) (18/45), after breast-conserving surgery. Six anatomical parameters were measured from planning CT images, including treatment planning target volume (PTV), cardiopulmonary volume ratio (CVR), maximum cardiac margin distance, the relative distance between inferior boundaries of heart and PTV (DBIB(H2P)), axial cardiac contact distance, and para-sagittal cardiac contact distance (CCDps). Multiple linear regression analysis was performed using SPSS software to explore the correlation between the six parameters, body mass index (BMI), and the mean heart dose (MHD). Receiver operating characteristic (ROC) analysis was performed to evaluate the predictive power of the selected predictor of cardiac dose exposure.

Results

Significant correlations were observed between the MHD of patients and the CVR, DBIB(H2P), and CCDps parameters. Among them, the CVR was the most important predictor of cardiac dose exposure, with an area under the curve of 0.915 and a cut-off value of 0.17.

Conclusions

The study results indicated that CVR, DBIB(H2P), and CCDps are the primary parameters associated with the risk of cardiac dose exposure, with CVR being the most significant predictor. Further prospective studies are required to determine whether these parameters can be used to identify patients who would benefit from the DIBH technique.
Awareness of Digital Preservation Among Pakistani Librarians
Authors: Ahmad Rafiq , Rafiq Muhammad
Published: July 2023

For implementation of effective and efficient digital preservation programs, librarians and other professionals in the memory institutions need to have sufficient levels of awareness of digital preservation key concepts, strategies, tools, and standards/best practices. This survey aimed to investigate the awareness of librarians in Pakistani universities about these components. The population of the study included the librarians working in the central libraries of public sector universities and degree awarding institutions (DAIs) of Pakistan established before 2010. A questionnaire was developed after reviewing the relevant literature and was thereafter pilot tested in selected libraries. After successful completion of this phase, data was collected from the target population. A total of 178 responses were received from 63 out of 70 universities and DAIs. Overall, respondents showed a good level of awareness of different components of digital preservation.
Interferon inhibits a model RNA virus via a limited set of inducible effector genes
Authors: McDougal Matthew B , De Maria Anthony M , Ohlson Maikke B , Kumar Ashwani , Xing Chao , Schoggins John W
Published: July 2023

Interferons control viral infection by inducing the expression of antiviral effector proteins encoded by interferon‐stimulated genes (ISGs). The field has mostly focused on identifying individual antiviral ISG effectors and defining their mechanisms of action. However, fundamental gaps in knowledge about the interferon response remain. For example, it is not known how many ISGs are required to protect cells from a particular virus, though it is theorized that numerous ISGs act in concert to achieve viral inhibition. Here, we used CRISPR‐based loss‐of‐function screens to identify a markedly limited set of ISGs that confer interferon‐mediated suppression of a model alphavirus, Venezuelan equine encephalitis virus (VEEV). We show via combinatorial gene targeting that three antiviral effectors—ZAP, IFIT3, and IFIT1—together constitute the majority of interferon‐mediated restriction of VEEV, while accounting for < 0.5% of the interferon‐induced transcriptome. Together, our data suggest a refined model of the antiviral interferon response in which a small subset of “dominant” ISGs may confer the bulk of the inhibition of a given virus.
Evaluasi Penerapan Community Based Tourism (CBT)
Authors: Diana Diana , Setiawan Avi Budi
Published: July 2023

Tourism is one of the growing sectors in Indonesia. One of the cities in Central Java that has both natural and artificial tourism potential is Pekalongan City. Nature tourism in Pekalongan City is still lacking in community involvement. The purpose of this study was to analyze the extent to which the existence and implementation as well as the obstacles in the implementation of Community Based Tourism (CBT) in these tours. Methods of data collection using interviews, observation, and documentation. The data analysis technique in this study used a narrative descriptive technique. The results showed that the community has been involved in tourism management but it is still not in accordance with the expected target. A good Community Based Tourism is the Pasir Kencana beach which is seen from the activity of a good tourism awareness group (Pokdarwis). Constraints in community-based tourism management in tourism are natural factors as well as factors from human resources.

 

Pariwisata merupakan salah satu sektor yang sedang berkembang di Indonesia. Salah satu Kota di Jawa Tengah yang memiliki potensi wisata baik alam dan buatan adalah Kota Pekalongan. Wisata alam di Kota Pekalongan masih kurang dalam keterlibatan masyarakatnya. Tujuan dari penelitian ini adalah untuk menganalisis sejauh mana eksistensi dan implementasi serta kendala dalam penerapan Community Based Tourism (CBT) di wisata tersebut. Metode pengumpulan data menggunakan wawancara, observasi, dan dokumentasi. Teknik analisis data pada penelitian ini menggunakan teknik deskriptif naratif. Hasil penelitian menunjukkan bahwa masyarakat sudah ikut terlibat dalam pengelolaan pariwisata namun masih belum sesuai dengan target yang diharapkan. Community Based Tourism yang baik adalah pantai pasir kencana dimana dilihat dari keaktifan kelompok sadar wisata (Pokdarwis) yang baik. Kendala dalam pengelolaan pariwisata berbasis masyarakat di wisata tersebut adalah faktor alam dan juga faktor dari sumber daya manusianya.
Factors Affecting Indonesia’s Import Duty Revenue
Authors: Syahni Putri Purnama
Published: July 2023

Import duty revenue is a source of government funds that can be used to finance development activities in an effort to create public welfare and grow a good progress of Indonesia’s economic activities. This study aims to analyze the factors that influence import duty revenue in Indonesia in the years 1989-2019. The analysis method used is multiple regression with the Error Correction Model (ECM) approach with time series data from 1989-2019. The results showed that the exchange rate of the IDR against the USD, the value of imports, and the index of economic openess had a significant effect on the acceptance of import duties revenue. This study suggests the government to be able to control the exchange rate of the IDR against the USD, tighten supervision related to procedures for import activities and be assessed not to make import duty revenue one of the main sources of state revenue.

 

Penerimaan bea masuk merupakan salah satu sumber dana pemerintah yang dapat digunakan untuk membiayai kegiatan pembangunan dalam upaya menciptakan kesejahteraan masyarakat dan kelancaran dalam kegiatan perekonomian Indonesia. Penelitian ini bertujuan untuk menganalisis factor-faktor yang mempengaruhi penerimaan bea masuk di Indonesia pada tahun 1989-2019. Metode analisis yang digunakan adalah regresi berganda dengan pendekatan Error Correction Model (ECM) dengan data time series dari tahun 1989-2019. Hasil penelitian menunjukkan bahwa kurs rupiah terhadap dollar AS, nilai impor, dan indeks keterbukaan ekonomi berpengaruh signifikan terhadap penerimaan bea masuk. Sementara volume impor tidak berpengaruh terhadap penerimaan bea masuk. Penelitian ini menyarankan pemerintah agar mampu mengendalikan nilai tukar rupiah terhadap dollar AS, memperketat pengawasan terkait prosedur kegiatan impor dan dinilai untuk tidak lagi menjadikan penerimaan bea masuk sebagai salah satu sumber utama dalam penerimaan negara.
Determinants of MSMEs Access to WIBAWA Credit
Authors: Sari Lusiana Puspita , Karsinah Karsinah
Published: July 2023

Capital need is a challenge experienced by MSME. Semarang city government provides an innovation of capital access assistance to MSMEs with Revolving Fund Loan Program, namely WIBAWA Credit. MSMEs status is feasible and not bankable, due to non-fulfillment of 5C principle. This study credit determinant analysis aims to develop a study of granting WIBAWA credit patterns. Secondary research data were obtained from Dinkop & UMKM Kota Semarang and PERUMDA BPR Bank Pasar Kota Semarang by taking a sample of 600 WIBAWA Credit application data for 2017-2019. Binary Logistic Regression analysis results through IBM SPSS Statistics 22 software show that there are differences in gender of business owners, business size, and business age in decision to grant WIBAWA credit, while credit history variable has no effect. Dinkop & MSMEs Kota Semarang need to improve creditworthiness of female business owners, micro-Enterprises, and start-up/new early businesses so that they have more opportunities to qualify for credit financing. MSMEs that re-apply for WIBAWA Credit can also be given a faster assessment process period and larger disbursement ceiling, but still, pay attention to credit repayment factor by debtor.

Kebutuhan modal menjadi tantangan yang dialami pemilik UMKM. Pemerintah Kota Semarang memberikan bantuan akses modal kepada UMKM dengan Program Pinjaman Dana Bergulir yaitu Kredit WIBAWA. Penelitian ini bertujuan untuk mengembangkan kajian terhadap pola pemberian Kredit WIBAWA. Data penelitian sekunder diperoleh dari Dinkop & UMKM Kota Semarang dan PERUMDA BPR Bank Pasar Kota Semarang dengan mengambil sampel 600 data pengajuan Kredit WIBAWA periode tahun 2017-2019. Hasil analisis Binary Logistic Regression melalui software IBM SPSS Statistics 22 menunjukkan bahwa terdapat perbedaan jenis kelamin pemilik usaha, ukuran usaha dan umur usaha dalam keputusan pemberian Kredit WIBAWA, sementara variabel riwayat kredit tidak memberikan pengaruh.