bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of the Phosphorus and Sulphur Levels on Growth and Yield of Mustard (Brassica juncea L.) Crop under Rainfed Condition
Authors: Patel Veerendra Kumar , Mishra U. S. , Singh Vivek Kumar
Published: July 2022

Background: Phosphorus has been pointed out as one of most important in oilseed crop wich is responsible for vegetative growth,reproduction and consequently yield of mustard. Sulphur element is important for crop growth and development especially in oilseed. At present, 42% of Indian soil have been found to the sulphur deficient, sulphur is essential for synthesis of oil percentage, protein, vitamins, in oilseed crops.

Methods: The field investigation was carried out at the Rajaula Research Farm, Faculty of Agricultural Science ,Mahatma Gandhi Chitrakoot Gramodaya Vishwavidyalay, Chitrakoot- Satna (M.P.) during Ravi season 2019-20. The treatment comprised three levels of phosphorus and three levels of sulphur along with absolute control.

Result: The result revealed that application of 30kg phosphorus/ha significantly increase the plant height , plant leaves, primary branches, secondary branches and yield indices vis number of siliqua/plant, number of seed/siliqua, 1000 seed weigh and seed yield than 20kg phosphrus/ha and 0kg phosphorus/ha . Sulphur levels also hed significantly influereced on these growth and yield indices and reconded higher values 20kg sulphur/ha found at per 10kg sulphur/ha and significantly higher over 0kh sulphur/ha. The finding that application of 30kg phosphorus with 20kg sulphur/ha proved the most optimum and beneficial fertility management for the Pusa Mahak veriety mustard for the Bundelkhand/ chitrakoot region of M.P.
Estudo Prospectivo ao Uso da Farinha do Mesocarpo do Coco Verde como Matéria-Prima para Elaboração de Alimentos
Authors: Silva Luís Paulo Firmino Romão da , Moraes Maria Suiane de , Esmero Janaína Almeida Dantas , Silva Semirames do Nascimento , Tomiyoshi Carlos Minor
Published: July 2022

A utilização da farinha do mesocarpo do coco verde como matéria-prima na elaboração de produtos alimentícios, considerando sua composição nutricional e características sensoriais, se destaca, principalmente, pelo elevado teor de fibras, que podem ser utilizadas como aditivo em produtos de panificação, sem alterar suas propriedades sensoriais. O trabalho foi realizado com o objetivo de levantar dados de depósitos de patentes sobre a utilização da farinha do coco verde por meio do mapeamento nas bases do INPI, Espacenet e USPTO. A pesquisa foi realizada em agosto de 2017, usando-se as palavras-chave “coco, produtos e farinha”, em português e em inglês. Os resultados mostraram que os depósitos de patentes que associam a utilização da farinha do mesocarpo do coco na produção de alimentos são escassos, justificando a necessidade de mais pesquisas nessa área, pois, além de poder agregar valor nutricional e econômico ao produto, isso pode diminuir a geração de resíduos provenientes do uso do coco, incentivando o investimento em ações sustentáveis.
Análise Prospectiva com Ênfase Científica e Tecnológica do Gênero Erythrina (Fabaceae)
Authors: Carvalho Adonias Almeida , Silva Luanda Ferreira Floro da , Freitas Jurema Santana de , Santiago Rodrigo Ferreira , Chaves Mariana Helena
Published: July 2022

O gênero Erythrina (Fabaceae) compreende 100 espécies de plantas de valor comercial e com propriedades biológicas importantes. O objetivo deste estudo foi realizar uma prospecção científica e tecnológica do gênero Erythrina. Os bancos de patentes pesquisados foram o European Patent Office (EPO), o Instituto Nacional da Propriedade Industrial (INPI) do Brasil, o Banco de Patentes Latino-Americanas (LATIPAT), o United States Patent and Trademark Office (USPTO) e o World Intellectual Property Organization (WIPO). A maioria das patentes está depositada na EPO e WIPO com 271 e 234 registros, respectivamente. O crescimento no número de patentes depositadas ocorreu a partir de 2010. A China, os Estados Unidos, o Canadá e o Japão são os principais depositantes de patentes envolvendo as espécies de Erythrina nas bases EPO e WIPO. As classificações internacionais mais frequentes das patentes foram A61K, seguida de A61P e C12N.
Uso de Poli-hidroxibutirato e Norbixina como Biomaterial para Regeneração Óssea: um mapeamento tecnológico
Authors: Sousa Rayssilane Cardoso de , Viana Vicente Galber Freitas , Carvalho Luiz Fernando Meneses , Vasconcelos Daniel Fernando Pereira
Published: July 2022

É crescente a associação de matrizes poliméricas e extratos naturais para a confecção de novos biomateriais na área de engenharia de tecidos. O presente trabalho propõe um estudo prospectivo sobre a aplicação de uma matriz polimérica contendo poli-hidroxibutirato e o apocarotenoide norbixina como biomaterial para fins de reparo ósseo. Foram realizadas buscas de artigos científicos publicados nos últimos dez anos, entre 2008 e 2018, nas bases de periódicos Web of Science, Scopus e Scielo. Para o mapeamento científico e tecnológico, considerou-se o levantamento total do número de patentes nos bancos de patentes do INPI, Espacenet e USPTO. A partir dos artigos e patentes revisados, constatou-se que a associação desses constituintes na engenharia de tecidos e em reparo ósseo é desconhecida. Porém, observou-se que os mesmos são conhecidamente utilizados como biomateriais com relevantes propriedades terapêuticas em diversos meios biológicos, tratando-se, portanto, de uma promissora área de pesquisa a ser explorada.
Prospecção Científica e Tecnológica do Uso do Óleo de Coco (Cocos nucifera. L) na Indústria Alimentícia
Authors: Araújo Talysie Freire , Sousa Luis Felipe Alves , Guimarães Denis Frota , Girão Mauro Vinicius Dutra
Published: July 2022

O óleo de coco tem se mostrado como um potencial alimento com benefícios nutricionais e funcionais. Este estudo tem como objetivo averiguar o estado da arte, realizando uma prospecção científica e tecnológica em relação ao uso do óleo de coco (CocosnuciferaL.) na indústria de alimentos. Para alcançar os objetivos foi realizado um levantamento das produções científicas da última década, bem como seu desenvolvimento tecnológico a partir da pesquisa realizada em bases de dados. Verificaram-se 1964 patentes com o óleo de coco, porém apenas três contemplaram os requisitos da pesquisa. Apesar de todos os aspectos positivos que o óleo apresenta, sua utilização para a produção de alimentos na indústria alimentícia se encontra escassa. Diante de todas as evidencias apresentadas sobre os benefícios do óleo de coco, sugere-se que pesquisas com esse alimento sejam desenvolvidas a fim de trazer novos estudos que promovam sua inovação tecnológica.
Proposta de Instrumentos para Gestão Mínima da Inovação Tecnológica em Indústrias de Eletrodomésticos
Authors: Miolo Robinson Aurélio , Rodrigues Antonio Wendell de Oliveira , Araújo André Luiz Carneiro de , Carvalho Tecia Vieira
Published: July 2022

A capacidade de inovar e se adaptar ao mercado em constante mudança é um fator de competitividade crescente para as indústrias de bens de consumo, contudo, os riscos e as incertezas inerentes à inovação são contrários à necessidade que as indústrias têm por segurança, previsibilidade e controle. Este estudo propõe uma nova abordagem da inovação tecnológica por meio da adoção de um conjunto de instrumentos que representem uma gestão mínima dos processos de inovação com a finalidade de minimizar incertezas, fracassos e seus impactos financeiros sem exigir das empresas abordagens excessivamente novas. Neste estudo, foi realizada uma pesquisa bibliográfica acerca desse problema, depois foi aplicada uma entrevista com gestores das principais empresas nacionais de linha branca e estudo de seus processos e, na sequência, foram apresentados os instrumentos da metodologia proposta. O estudo sugere que uma abordagem acessível poderá viabilizar a inovação tecnológica e promover o fortalecimento da indústria nacional.
Estudo Prospectivo sobre o Uso da Técnica de Biorremediação para a Recuperação de Solos Contaminados por Derivados do Petróleo
Authors: Sousa Kamilla Costa de , Santos Júnior José Edilson dos , Santos Vivianni Marques Leite dos
Published: July 2022

Acidentes e vazamentos que envolvem produtos derivados de petróleo afetam bastante a natureza, pois o solo é fortemente prejudicado. Na busca por remediação, podem ser utilizados processos biológicos sobre a promissora relação custo/eficiência, com a devida consideração de fatores, como pH e umidade. Assim, este artigo tem como objetivo relatar os principais fatores envolvidos e os tipos de técnicas de biorremediação de solos contaminados por petróleo e seus derivados, bem como as principais iniciativas com geração de patentes. Foram identificadas seis famílias de patentes, com o primeiro pedido de proteção no Brasil, em 2007, pela Rhodia Poliamida & Especialidades, detendo a maior família de patentes depositadas em sete organizações ou países. É do Brasil a patente para um dispositivo móvel, concedida para o Instituto de Pesquisas Tecnológicas do Estado de São Paulo. Ao final, conclui-se pela viabilidade de aplicação da técnica e pela possibilidade de inovações incrementais.
Minimal Impact of the COVID‐19 Pandemic on Disease Activity and Health‐Related Quality of Life in Patients With Ankylosing Spondylitis Receiving Bimekizumab: Exploratory Analyses From a Phase 2b Open‐Label Extension Study
Authors: Robinson Philip C. , Machado Pedro M. , Haroon Nigil , Gensler Lianne S. , Reveille John D. , Taieb Vanessa , Vaux Thomas , Fleurinck Carmen , Oortgiesen Marga , de Peyrecave Natasha , Deodhar Atul
Published: July 2022

Objective

The impact of the COVID‐19 pandemic on patients with inflammatory rheumatic diseases, such as ankylosing spondylitis (AS), has been variable. Here, we assess disease activity and health‐related quality of life (HRQoL) through the pandemic in patients with AS.

Methods

In the open‐label extension (OLE) of the phase 2b BE AGILE study, patients with AS received 160 mg of subcutaneous bimekizumab every 4 weeks. We assessed Ankylosing Spondylitis Disease Activity Score with C‐reactive protein (ASDAS‐CRP), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Ankylosing Spondylitis Quality of Life (ASQoL) scores in the OLE immediately before and during the COVID‐19 pandemic (September 2019 to April 2021).

Results

A total of 232 patients remained in the BE AGILE OLE and were included in this post hoc study at the start of the analysis period (September 1, 2019); 12 patients had a COVID‐19 treatment‐emergent adverse event, and no cases resulted in death. The number of missed bimekizumab doses due to COVID‐19 (11 doses) was minimal, and missed assessments remained low (≤5%) compared with the prepandemic period. Mean ASDAS‐CRP (1.8), BASDAI (2.4), and ASQoL scores (2.8) in the OLE were low at pre‐pandemic baseline and remained stable at 1.7 to 1.8, 2.2 to 2.4, and 2.0 to 2.8, respectively, across successive 3‐month periods immediately before and during the pandemic. ASDAS‐CRP, BASDAI, and ASQoL stability was consistent across major study countries.

Conclusion

Disease activity and HRQoL remained stable during the COVID‐19 pandemic in patients with AS receiving bimekizumab in the BE AGILE OLE, with no indication of negative effects on these outcomes.
Biointerface Engineering with Nucleic Acid Materials for Biosensing Applications
Authors: Shi Shi , Chen Jing , Wang Xiwei , Xiao Mingshu , Chandrasekaran Arun Richard , Li Li , Yi Chengqing , Pei Hao
Published: July 2022

Molecular recognition at the biointerface plays a critical role in sensing molecular interactions (e.g., DNA hybridization) and extracellular changes, which can directly affect the detection performance of biosensors (e.g., sensitivity, specificity, and response dynamics). However, conventional sensing biointerfaces show low molecular recognition efficiency due to limited target accessibility. Engineering sensing biointerfaces to regulate the orientation, spacing, and density of surface‐confined molecular probes offer an effective approach to improve molecular recognition at interfaces. Over the last decades, biointerface engineering with nucleic acid materials has advanced the fundamental understanding of DNA hybridization kinetics and facilitated the design of improved biosensing platforms for monitoring cellular activities and diagnosing relevant diseases. This review summarizes the recent progress in nucleic acid‐based biointerface engineering. The development of nucleic acid materials that can be applied to specific diagnostic applications is briefly introduced. Then the roles of nucleic acids in tailoring the properties of nanosurfaces, cell surfaces, and macroscopic surfaces are discussed and their biosensing applications are comprehensively highlighted. Finally, future challenges and perspectives of emerging technologies and applications in the field are presented.
Injectable, Self‐healing, and 3D Printable Dynamic Hydrogels
Authors: Lee Hung Pang , Deo Kaivalya A. , Jeong Jinwoo , Namkoong Myeong , Kuan Kai Yuan , Tian Limei , Gaharwar Akhilesh K.
Published: July 2022

Dynamic hydrogels are promising biomaterials for various biomedical and biotechnological applications due to their ability to change physicochemical properties and functions reversibly and/or sequentially in a time‐ or stimuli‐dependent manner. In this study, a new class of dynamic hydrogels that are crosslinked by the in situ redox reactions of gold ions and disulfide groups are developed. Specifically, the gold ions initiate hydrogel formation via gold‐thiol crosslinking, transforming the hydrogel from an injectable hydrogel to a mechanically stable and tough hydrogel. Moreover, the in situ nucleation and growth of gold nanoparticles within the crosslinked hydrogel networks further enhance electrical conductivity. The current work demonstrates the utility of these dynamic hydrogels for 3D printing and drug delivery.
Size‐Dependent Photon Avalanching in Tm3+ Doped LiYF4 Nano, Micro, and Bulk Crystals
Authors: Dudek Magdalena , Szalkowski Marcin , Misiak Małgorzata , Ćwierzona Maciej , Skripka Artiom , Korczak Zuzanna , Piątkowski Dawid , Woźniak Piotr , Lisiecki Radosław , Goldner Philippe , Maćkowski Sebastian , Chan Emory M. , Schuck P. James , Bednarkiewicz Artur
Published: July 2022

Photon avalanche (PA) is a highly nonlinear mode of upconversion that is characterized by 100–1000‐fold increase in luminescence intensity upon minute increments of pumping power. The practical realization of numerous possible nano‐bio‐technology applications utilizing the PA phenomenon will require information on its susceptibility to the material volume and surface. Here, these parameters are investigated via experimental and theoretical PA. The two‐color, highly nonlinear PA emission at 475 and 800 nm is clearly observed in bulk single crystal, individual microcrystals, and ensembles of colloidal core and core–shell nanoparticles of LiYF4 host doped with either 3 or 8% of thulium ions. The properties of PA emission, such as PA nonlinearity, PA gain, PA intensity, and luminescence kinetics in these materials show dependence on crystal volume and surface quenching. Theoretical simulations provide understanding of key physical processes that influence PA performance. Moreover, photon avalanche single beam super‐resolution imaging is realized for the first time in 3% Tm3+ doped LiYF4 core–shell nanoparticles. The obtained insights and predictions form a solid background for further development and applications of new optimized PA materials.
Deep‐Blue Light‐Emitting Diodes Constructed with Perovskite Quasi‐2D and Nanocrystal Mixtures
Authors: Pang Peiyuan , Xing Zhaohui , Xia Junmin , Wang Bingzhe , Zhang Zhipeng , Guo Jia , Liu Tanghao , He Bingchen , Chen Jiangshan , Chen Shi , Xing Guichuan
Published: July 2022

In the past several years, metal‐halide perovskites have attracted much attention for their promising applications in light‐emitting diodes (LEDs). Significant progress has been made in the development of high‐efficiency green, red, and near‐infrared perovskite LEDs (PeLEDs), but blue PeLEDs are still lagging behind. Although the external quantum efficiency (EQE) of blue PeLEDs has exceeded 10%, these works mainly focus on pure blue and sky‐blue regions. Creating deep‐blue electroluminescence (EL) with high stability, efficiency, and color purity is still a great challenge for PeLEDs. Herein, deep‐blue PeLEDs are reported which have been constructed with a mixture of a quasi‐2D phase and a nanocrystal phase by introducing a small diamine cation, ethylene diammonium (EDA2+), and the effect of EDA2+ on quasi‐2D perovskite crystallization is investigated. EDA2+ with two amino ending groups has a stronger inhibitory effect on high‐n phase growth than phenylethyl ammonium, leading to the formation of small nanocrystals. Further introduction of Na+ reduces the size of the nanocrystals and broadens the band gap. Based on these improvements, deep‐blue PeLEDs with EL peaks at 467 (EQE ≈ 1.7%) and 461 nm (EQE ≈ 1.1%) are successfully constructed. Thus, this study provides a useful strategy for improving the performance of deep‐blue PeLEDs.
Reversible Charge‐Polarity Control for Multioperation‐Mode Transistors Based on van der Waals Heterostructures
Authors: Chen Ciao‐Fen , Yang Shih‐Hsien , Lin Che‐Yi , Lee Mu‐Pai , Tsai Meng‐Yu , Yang Feng‐Shou , Chang Yuan‐Ming , Li Mengjiao , Lee Ko‐Chun , Ueno Keiji , Shi Yumeng , Lien Chen‐Hsin , Wu Wen‐Wei , Chiu Po‐Wen , Li Wenwu , Lo Shun‐Tsung , Lin Yen‐Fu
Published: July 2022

Van der Waals (vdW) heterostructures—in which layered materials are purposely selected to assemble with each other—allow unusual properties and different phenomena to be combined and multifunctional electronics to be created, opening a new chapter for the spread of internet‐of‐things applications. Here, an O2‐ultrasensitive MoTe2 material and an O2‐insensitive SnS2 material are integrated to form a vdW heterostructure, allowing the realization of charge‐polarity control for multioperation‐mode transistors through a simple and effective rapid thermal annealing strategy under dry‐air and vacuum conditions. The charge‐polarity control (i.e., doping and de‐doping processes), which arises owing to the interaction between O2 adsorption/desorption and tellurium defects at the MoTe2 surface, means that the MoTe2/SnS2 heterostructure transistors can reversibly change between unipolar, ambipolar, and anti‐ambipolar transfer characteristics. Based on the dynamic control of the charge‐polarity properties, an inverter, output polarity controllable amplifier, p‐n diode, and ternary‐state logics (NMIN and NMAX gates) are demonstrated, which inspire the development of reversibly multifunctional devices and indicates the potential of 2D materials.
Hydrogen Tunneling in Catalytic Hydrolysis and Alcoholysis of Silanes
Authors: Almenara Naroa , Garralda Maria A. , Lopez Xabier , Matxain Jon M. , Freixa Zoraida , Huertos Miguel A.
Published: July 2022

An unprecedented quantum tunneling effect has been observed in catalytic Si−H bond activations at room temperature. The cationic hydrido‐silyl‐iridium(III) complex, {Ir[SiMe(o‐C6H4SMe)2](H)(PPh3)(THF)}[BArF4], has proven to be a highly efficient catalyst for the hydrolysis and the alcoholysis of organosilanes. When triethylsilane was used as a substrate, the system revealed the largest kinetic isotopic effect (KIESi−H/Si−D=346±4) ever reported for this type of reaction. This unexpectedly high KIE, measured at room temperature, together with the calculated Arrhenius preexponential factor ratio (AH/AD=0.0004) and difference in the observed activation energy [(E
−E
)=34.07 kJ mol−1] are consistent with the participation of quantum tunneling in the catalytic process. DFT calculations have been used to unravel the reaction pathway and identify the rate‐determining step. Aditionally, isotopic effects were considered by different methods, and tunneling effects have been calculated to be crucial in the process.
Aufklärung der CO2‐Hydrierung über In2O3‐Nanopartikeln mittels Operando UV/Vis‐ und Impedanzspektroskopie
Authors: Ziemba Marc , Radtke Mariusz , Schumacher Leon , Hess Christian
Published: July 2022

Während sich In2O3 als vielversprechender Katalysator für die CO2‐Aktivierung erwiesen hat, fehlt bisher ein grundlegendes Verständnis seiner Funktionsweise bei der CO2‐Hydrierung, da die Anwendung der operando‐Schwingungsspektroskopie aufgrund von Absorptionseffekten eine Herausforderung darstellt. In dieser mechanistischen Studie untersuchen wir systematisch die Redox‐Prozesse im Zusammenhang mit der reversen Wassergas‐shift‐Reaktion (rWGSR) über In2O3‐Nanopartikeln, sowohl an der Oberfläche als auch in der Bulkstruktur. Basierend auf temperaturabhängigen operando‐UV/Vis‐Spektren und einem neuartigen operando‐Impedanz‐Ansatz für thermische Pulverkatalysatoren schlagen wir die Oxidation durch CO2 als den geschwindigkeitsbestimmenden Schritt für die rWGSR vor. Die Ergebnisse stimmen mit Redox‐Prozessen überein, wobei wasserstoffhaltige Oberflächenspezies nachweislich eine fördernde Wirkung aufweisen. Unsere Ergebnisse zeigen, dass für die Aktivität neben Oberflächenprozessen die Sauerstoff/Wasserstoff‐Dynamik wichtig ist, was nicht nur für In2O3, sondern auch für andere reduzierbare Oxidkatalysatoren von Bedeutung sein dürfte.
(4+3) Annulation of Donor‐Acceptor Cyclopropanes and Azadienes: Highly Stereoselective Synthesis of Azepanones
Authors: Nicolai Stefano , Waser Jérôme
Published: July 2022

Azepanes are important seven‐membered heterocycles, which are present in numerous natural and synthetic compounds. However, the development of convergent synthetic methods to access them remains challenging. Herein, we report the Lewis acid catalyzed (4+3) annulative addition of aryl and amino donor‐acceptor cyclopropanes with 2‐aza‐1,3‐dienes. Densely substituted azepane derivatives were obtained in good to excellent yields and with high diastereoselectivity. The reaction occurred under mild conditions with ytterbium triflate as the catalyst. The use of copper triflate with a trisoxazoline (Tox) ligand led to an enantioselective transformation. The obtained cycloadducts were convenient substrates for a series of further modifications, showing the synthetic utility of these compounds.
Multienzyme Redox System with Cofactor Regeneration for Cyclic Deracemization of Sulfoxides
Authors: Peng Tao , Tian Jin , Zhao Yuyan , Jiang Xu , Cheng Xiaoling , Deng Guozhong , Zhang Quan , Wang Zhongqiang , Yang Jiawei , Chen Yongzheng
Published: July 2022

Optically pure sulfoxides are noteworthy compounds applied in a wide range of industrial fields; however, the biocatalytic deracemization of racemic sulfoxides is challenging. Herein, a high‐enantioselective methionine sulfoxide reductase A (MsrA) was combined with a low‐enantioselective styrene monooxygenase (SMO) for the cyclic deracemization of sulfoxides. Enantiopure sulfoxides were obtained in >90 % yield and with >90 % enantiomeric excess (ee) through dynamic “selective reduction and non‐selective oxidation” cycles. The cofactors of MsrA and SMO were subsequently regenerated by the cascade catalysis of three auxiliary enzymes through the consumption of low‐cost D‐glucose. Moreover, this “one‐pot, one‐step” cyclic deracemization strategy exhibited a wide substrate scope toward various aromatic, heteroaromatic, alkyl and thio‐alkyl sulfoxides. This system proposed an efficient strategy for the green synthesis of chiral sulfoxide.
Structural and luminescence studies of titanium co‐doped SrY2O4:Eu phosphors
Authors: Bhatia Smriti , Priya Ruby , Kumar Dinesh , Upadhyay Sanjay , Pandey Om Prakash
Published: July 2022

Here, europium‐doped (1 to 11 mol%) and titanium (1 to 5 mol%)co‐doped SrY2O4:Eu phosphors were synthesized using solid‐state reaction method. The synthesized samples were characterized using X‐ray diffraction (XRD), field emission scanning electron microscopy (FESEM), Fourier transform infrared spectroscopy (FTIR), and photoluminescence (PL) techniques for structural, morphological, functional group, and photoluminescence studies, respectively. XRD patterns confirmed the formation of pure phase SrY2O4 at 1300°C and structural parameters were further determined using Rietveld refinement. FESEM micrographs revealed that doped and co‐doped samples had different morphological features. All the samples were excited at ultraviolet light excitation and emission spectra consisted of peaks corresponding to the Eu ions. The maximum PL intensity was observed for 9 mol% of Eu ions and 3 mol% co‐doping of Ti ions. The synthesized phosphors have potential applications in optoelectronics and display devices.
First derivative synchronous spectrofluorimetric analysis of bisoprolol fumarate and ivabradine in pharmaceutical and biological matrices. Investigation of the method greenness
Authors: Abo Elkheir Shrouk M. , Zeid Abdallah M. , Nasr Jenny Jeehan M. , Walash Mohamed I.
Published: July 2022

A novel, facile, rapid, and precise synchronous spectrofluorimetric method was evolved for the simultaneous estimation of bisoprolol fumarate and ivabradine in dosage forms and biological fluids. The estimation is based on measuring the first derivative of the synchronous fluorescence spectra of ivabradine and bisoprolol fumarate in ethanol at Δλ = 80 nm. The peak amplitudes are measured at 234.4 nm (zero‐crossing point of ivabradine) and 244.0 nm (zero‐crossing point of bisoprolol fumarate) to simultaneously analyze bisoprolol fumarate and ivabradine, respectively. The spectrofluorimetric method was optimized by investigating different solvent systems, pH values, and surfactants. The proposed method was linear over concentration ranges 30.0–200.0 ng/ml and 30.0–180.0 ng/ml for ivabradine and bisoprolol fumarate, respectively with detection limits of 4.88 and 5.28 ng/ml. The developed method was used for individual assay of the studied compounds in their pharmaceutical dosage forms with high percentage recoveries. Moreover, the method was applied to analyze ivabradine and bisoprolol fumarate in spiked human urine with percentage recoveries of 99.98 ± 1.16 and 99.95 ± 1.96 for ivabradine and bisoprolol fumarate, respectively. The method greenness was also investigated by Analytical GREEnness (AGREE), Analytical Eco‐Scale, and Green Analytical Procedure Index (GAPI) metrics, which ensured the ecofriendship of the proposed method.
Coping strategies in parents of children with disabilities: A case‐control study
Authors: Alós Francisco J. , García Andrés García , Maldonado Miguel A.
Published: July 2022

Introduction

The aim of this article is to determine whether there are differences in the coping strategies of parents of children with disabilities (autism spectrum disorder or other disabilities) and children without disabilities, in reference to the most stressful situation they have experienced with their child in the last year.

Method

To conduct the study, a purposive sample selection based on case‐control characteristics was carried out, in which a total sample of 170 participants was recruited. Participants were assigned, according to their characteristics, to the group of parents of children without disabilities, with ASD or with other disabilities. An ad hoc sociodemographic questionnaire and the Coping Responses Inventory for adults were administered.

Results

The results obtained indicate that there are differences in the use of coping strategies between parents of children without disabilities and with disabilities but not between the two disability groups. Parents of children with disabilities have significantly higher scores on the four subscales defined as avoidance strategies, and on one subscale identified as an approach strategy.

Conclusions

Parents of children with disabilities use avoidance strategies, to a greater extent, during the most stressful situations they have experienced in the last year with their child. In addition, they tend to use avoidance strategies regardless of the type of disability their child has.
Corporate environmental investment and supply chain financing: The moderating role of environmental innovation
Authors: Zhu Xuehong , Liu Ran , Chen Jinyu
Published: July 2022

Using microdata from listed Chinese firms for 2009–2019, we examined whether and how corporate environmental investments affect supply chain financing. We further investigated the moderating effect of two types of environmental innovation (i.e., voluntary versus compliance environmental innovations). The findings revealed that firms with high levels of environmental investments were more inclined to obtain supply chain financing. This evidence suggests the positive effects of supply chain stakeholders in promoting corporate environmental governance. Moreover, the association could be more or less pronounced for firms with high levels of compliance or voluntary environmental innovation, respectively. Furthermore, channel tests indicated that social responsibility and transaction trust were the primary channels for explaining the above relationships. Finally, the positive relationship between environmental investment and supply chain financing only held for firms located in different cities from the supply chain firms and firms with high social attention. These findings highlight the heterogeneous role of environmental innovation and public governance in alleviating firms' financing constraints.
Early detection of pleuro‐pulmonary tuberculosis by bedside lung ultrasound: A case report and review of literature
Authors: Cocco Giulio , Boccatonda Andrea , Rossi Ilaria , D’Ardes Damiano , Corvino Antonio , Delli Pizzi Andrea , Ucciferri Claudio , Katia Falasca , Jacopo Vecchiet
Published: July 2022

We present a case in which lung ultrasound (LUS) was relevant to reach an early diagnosis of lung tuberculosis and to manage the patient in the right setting. Moreover, ultrasound allowed to detect and treat massive pleural effusion through an ultrasound‐guided thoracentesis.
SARS‐CoV‐2, HIV, and Mycobacterium tuberculosis triple co‐infection
Authors: Ngouanom Kuate Marius Paulin , Bongomin Felix , Ndip Roland Ndip
Published: July 2022

Tuberculosis (TB)‐related death has increased for the first time in a decade due to the coronavirus disease 2019 (COVID‐19), globally. People living with HIV (PLWHIV) might be at a higher risk of developing COVID‐19‐related complications. Herein, we describe the first case of a patient surviving from SARS‐CoV‐2‐TB‐HIV triple co‐infection in Cameroon. A 36‐year‐old Cameroonian woman presented at the emergency unit of the Jamot Hospital, Yaoundé with symptoms of anorexia, productive cough, weight loss, and fever. The SARS‐CoV‐2 rapid antigen test on nasopharyngeal sample was positive. Chest X‐ray showed bilateral parenchymal and tracheal calcifications most consistent with prior pulmonary histoplasmosis, varicella, or TB. She was tested HIV positive, and the sputum sample tested positive for TB on auramine staining. TB therapy (rifampicin, isoniazid, pyrazinamide, and ethambutol) and COVID‐19 treatment were initiated, and the symptoms improved after 2 weeks of treatment. The SARS‐CoV‐2 rapid antigen and real‐time polymerase chain reaction tests were negative after 2 weeks. She was discharged home on antiretroviral therapy and TB therapy. Coinfection with both TB, HIV, and SARS‐CoV‐2 may be common in Cameroon but not reported. The similar clinical features of COVID‐19 and TB usually lead to misdiagnosis. Early diagnosis and initiation of appropriate treatment improve outcome.
Retroperitoneal myxosarcoma in a cat
Authors: Hixson Haleigh , Coutermarsh‐Ott Sheryl , Ciepluch Brittany , Kierski Katharine , Lahmers Kevin , Tuohy Joanne
Published: July 2022

This report details a retroperitoneal myxosarcoma in a cat that exhibited extremely aggressive biological behavior. An exploratory midline celiotomy revealed a left‐sided retroperitoneal mass firmly adhered to the hypaxial musculature. Histopathological evaluation identified the mass as a myxosarcoma. Following surgical excision, the mass rapidly recurred within 6 weeks after surgery.
Giant ovarian mucinous cystadenocarcinoma: A case report
Authors: Shrestha Bibek Man , Shrestha Suraj , Kharel Sanjeev , Aryal Shiva , Rauniyar Robin , Kuikel Sandip , Tiwari Sansar Babu , Chaurasia Hemu , Chapagain Sandip , Shrestha Prezma
Published: July 2022

Giant ovarian tumors are rare in the present day due to the early diagnosis and treatment. However, owing to the large size, it can often compress the inferior vena cava and sudden decompression of it during the removal can lead to hemodynamic instability with disastrous outcomes.
One Fluorophore‐Two Sensing Films: Hydrogen‐Bond Directed Formation of a Quadruple Perylene Bisimide Stack
Authors: Gou Xinyu , Wang Zhaolong , Shi Qiyuan , Liu Ke , Jiang Qingwei , Lin Simin , Miao Rong , Fang Yu
Published: July 2022

Elaborately designed π‐stacked molecular aggregates are significant for modulation of photophysical properties of polycyclic aromatic hydrocarbons (PAHs). Herein, a double hydrogen‐bonds trussed di(pyridyl)pyrrole‐perylene bisimide (HDPP‐PBI) was designed and its dimerization behavior was studied. HDPP‐PBI tends to form a quadruple PBI stack with a dimerization constant of ∼5.56×106 M−1. The dimerization was ascribed to synergistic intramolecular double hydrogen‐bonds formation and intermolecular π‐π stacking. Addition of CF3COOH, a hydrogen bond blocker, promotes the dimer to monomer transition. Accordingly, two distinct fluorescent films were prepared by drop‐casting of the dimerized or the monomeric HDPP‐PBI onto a substrate surface. Interestingly, the less‐emissive PBI quadruple stack‐based film showed a turn on response to acetone vapor, while the highly emissive HDPP‐PBI‐based film exhibited fluorescence quenching upon exposure to triethylamine vapor. We believe that the discovered synergistic effect in the PBI aggregates would enlighten the design of new PAHs aggregates with defined structures.
Theoretical calculation guided materials design and capture mechanism for Zn–Se batteries via heteroatom‐doped carbon
Authors: Wang Hongrui , Lai Kang , Guo Fangyu , Long Bei , Zeng Xianxiang , Fu Zhiqiang , Wu Xiongwei , Xiao Yao , Dou Shixue , Dai Jiayu
Published: July 2022

Zinc–selenium (Zn–Se) batteries have generated great research interest because they could potentially meet the requirements of a high‐capacity, high energy density storage device. Unfortunately, efforts to control the shuttle effect of polyselenides have yielded limited success. Nanostructured carbon hosts with nonpolar surfaces have insufficient ability to restrict polyselenides within the cathode. Herein, first‐principles calculations are used to successfully study the merits of heteroatom‐doped graphene as an efficient sorbent with an excellent ability to inhibit the shuttle effect of polyselenides. The calculation results show that using B as a dopant could distinctly enhance interaction between hosts and polyselenides, which occur significant charge transfer with polyselenides and reduce the diffusion energy barrier of Zn ions. Then, we synthesized carbon/Se and boron‐doped carbon material/Se composite cathodes proving that B‐doped carbon could restrict the shuttle effect of polyselenides, which increases the electrochemical performance of Zn–Se batteries. Therefore, the theoretical study identifies a delightful restricted material that could potentially restrict the shuttle effect in Zn–Se batteries and provides a foundation and strategy for the fabrication of long‐life, high‐power‐density Zn–Se batteries.
Anion exchange membrane water electrolysis for sustainable large‐scale hydrogen production
Authors: Lee Sol A , Kim Jaehyun , Kwon Ki Chang , Park Sun Hwa , Jang Ho Won
Published: July 2022

The development of sustainable energy technology has received considerable attention to meet the increasing energy demands and realize carbon neutrality. Hydrogen is a promising alternative energy source to replace fossil fuels and mitigate environmental issues. However, most hydrogen is produced by reforming fossil fuels, called gray hydrogen, and the production of gray hydrogen emits a large amount of carbon dioxide. As a sustainable approach, water electrolysis technology has been developed to produce high‐purity hydrogen, called green hydrogen. Among various technologies, water electrolysis equipped with an anion exchange membrane has been regarded as an attractive pathway for large‐scale H2 production at a low cost. The status of anion exchange membrane water electrolyzers is approaching toward megawatt‐scale H2 production by companies, which has the potential to become competitive technology for existing water electrolyzers (alkaline electrolyzer, proton exchange membrane electrolyser). This review article represents recent advances in the development of major components (membrane, catalyst, membrane electrode assembly) of anion exchange water electrolyzers. By recognizing the current water electrolysis performance and solving the remaining challenges, anion exchange membrane electrolysis can be a leading technology for green hydrogen production.
The Mechanical Properties of Inorganic Thermoelectric Materials: A Review on Characterization Methods and Correlations
Authors: Guttmann Gilad M. , Haroush Shlomo , Gelbstein Yaniv
Published: July 2022

The conversion of thermal energy into electricity can be successfully applied by novel renewable energy known as thermoelectricity (TE). Such thermoelectric generators (TEGs) are currently at a technological readiness level (TRL) of 3–5 (out of a level of 10) approaching laboratory prototypes. One of the major setbacks to achieve higher TRLs is the fact that the focus of research is concentrated on improving the electronic/transport properties (mainly affecting the figure of merit – ZT) of the materials, while the research on the mechanical properties and the material‘s ability to adhere service conditions was left behind. Information about the mechanical properties of TE materials – elastic constants (e. g. Young's modulus and Poisson's ratio), strength, and fracture toughness – are paramount necessities (but not the only ones) for approaching practical TEGs. The elastic constants provide an understanding of the material‘s stiffness, while the strength and fracture toughness provide the loading conditions the material can endure. This work summarizes the various mechanical properties and measuring methods along with all up‐to‐date published data of these properties for inorganic TE materials. This work aims to expose the TE community to the under‐looked and nearly untreated field of research. Also, for the first time, a statistical analysis of the collected data was employed to highlight cross relations between mechanical, and physical properties and those who had a high Pearson's correlation parameter are presented. These correlations in turn have the potential to expedite the development and screening of inorganic TE materials for the various applications needed.
Multi‐objective moth swarm based sailfish model for optimal routing in wireless sensor network
Authors: Gunasekar Manikandan , Natesan Gobalakrishnan , Samiayya Duraimurugan
Published: July 2022

In recent years, the WSN are emerging swiftly since it finds applications in various domains including weather monitoring, attack detection, industrial monitoring, monitoring of submarine organisms, patient monitoring as well as the monitoring of ecological disorders. But WSN is also influenced by various other factors like network lifetime and energy consumption. It is necessary to provide an energy effective protocol to conquer certain troubles that includes packet delivery ratio, network lifetime, residual energy as well as effective routing in WSN. Therefore, this article aims to propose a novel protocol to enhance the energy efficiency of the network thereby providing an optimal routing path. This can be achieved by selecting an optimal cluster head that maintains communication between the base station and the sensor node. In this article, a novel multi‐objective moth swarm based sailfish (MOMS‐SF) technique is employed in selecting an optimal cluster head. The proposed MOMS‐SF technique enhances the network lifetime and minimizes the energy consumption of the network. Finally, the evaluation results are conducted to determine the network performances of the proposed MOMS‐SF approach. Also, a comparative analysis is carried out and the graphical analyzes for various parameters are made for various approaches to determine the effectiveness of the proposed system.
Modified unbiased estimators for population variance: An application for COVID‐19 deaths in Russia
Authors: Oncel Cekim Hatice
Published: July 2022

The article deal with the class unbiased forms of the variance estimators using Hartley–Ross type in the simple random sampling. The mean squared error (since it is an unbiased estimator, variance is calculated) of the suggested, up to the first order of approximation, is derived. The proposed estimator using COVID‐19 data in Russia has been proven to be more efficient than the considered estimators under the conditions. Thus, it allows us to see the variance estimator that best predicts the change according to federal regions in Russia's number of COVID‐19 deaths. This study also provides an unbiased family of estimators that are more efficient than existing estimators, which estimate the variance of the total death number of COVID‐19 based on the daily new cases number. The most important difference of this article from other studies in the literature is that it is the first study to examine the variance of the COVID‐19 cumulative mortality value in terms of variance estimation using the simple random sampling method with the auxiliary variable.
Full Assessment of Lung Mechanics Using Computer‐Controlled, Forced Oscillation Technique
Authors: De Guia Roldan Medina , Zatecka Vaclav , Rozman Jan , Prochazka Jan , Sedlacek Radislav
Published: July 2022

The forced oscillation technique (FOT) is a powerful and accurate method to quantify the mechanical properties of the airways and tissues of the respiratory system. Here we provide a detailed protocol for the measurement of mouse respiratory mechanical parameters. We present a procedure for mouse endotracheal intubation using a handcrafted intubation platform and confirmation module. The FlexiVentFX™ system (Scireq Inc.) is utilized for the thorough assessment of lung function with the FlexiWare™ software serving as a unit for the planning, experimentation, and analysis. The protocol has been standardized and adapted for use by our center for lung‐function phenotyping of mouse models generated for the International Mouse Phenotyping Consortium (IMPC). The simplified steps, technical considerations, and integrated hardware‐software demonstration make this protocol adaptable and implementable for researchers interested in using FOT for lung‐function evaluation. © 2022 The Authors. Current Protocols published by Wiley Periodicals LLC.

Support Protocol 1: Assembly of the FlexiVentFX™ system for measurements

Support Protocol 2: FlexiWare database management

Support Protocol 3: A guide for the construction of intubation platform and confirmation module

Basic Protocol 1: Mouse endotracheal intubation

Basic Protocol 2: Assessment of mouse basal lung function
Targeting Valuable Chemical Commodities: Hydrazine‐mediated Diels‐Alder Aromatization of Biobased Furfurals
Authors: Cioc Răzvan C. , Crockatt Marc , van der Waal Jan C. , Bruijnincx Pieter C. A.
Published: July 2022

A hydrazine‐mediated approach towards renewable aromatics production via Diels‐Alder aromatization of readily available, biobased furfurals was explored as alterative to the more classical approaches that rely on reactive but uneconomical reduced dienes (e. g., 2,5‐dimethylfuran). To enable cycloaddition chemistry with these otherwise unreactive formyl furans, substrate activation by N,N‐dimethyl hydrazone formation was investigated. The choice of the reaction partner was key to the success of the transformation, and in this respect acrylic acid showed the most promising results in the synthesis of aromatics. This strategy allowed for selectivities up to 60 % for a complex transformation consisting of Diels‐Alder cycloaddition, oxabridge opening, decarboxylation, and dehydration. Exploration of the furfural scope yielded generic structure‐reactivity‐stability relationships. The proposed methodology enabled the redox‐efficient, operationally simple, and mild synthesis of renewable (p‐disubstituted) aromatics of commercial importance under remarkably mild conditions.
Greater social adversity is associated with more disordered eating attitudes and behaviors among children from Southeast Michigan
Authors: McGowan Andrea , Barry Mikayla R. , Sonneville Kendrin R. , Leung Cindy W.
Published: July 2022

Objective

The objective of this study is to examine the association between indicators of social adversity, including socioeconomic status and race/ethnicity, and children's disordered eating behaviors and attitudes.

Methods

Children ages 8–10 years old (n = 183) were recruited from Michigan. Data were collected through in‐home surveys. The Children's Eating Attitudes Test (ChEAT‐24) measured disordered eating attitudes and behaviors in the sample. Cumulative social adversity was considered the sum of four binary variables: caregiver race/ethnicity, caregiver education, household income, and child‐reported food security status. Linear mixed models examined the association between social adversity indicators and ChEAT‐24 scores.

Results

Children of primary caregivers of color had significantly higher ChEAT‐24 scores than children of white caregivers (p = .03). Children who reported food insecurity had significantly higher ChEAT‐24 scores compared to children who reported food security (p = .01). Compared to children with the lowest social adversity score, children with the highest score had a 4.8‐unit higher ChEAT‐24 score (95% CI .3–9.4), after adjusting for covariates. A significant trend was observed for greater social adversity and higher ChEAT‐24 score (p‐trend = .02).

Conclusion

A linear association was observed between greater social adversity and more disordered eating behaviors and attitudes among children in this sample. These findings emphasize the need for eating disorder research in children from racial/ethnic minorities and socioeconomically disadvantaged populations to support future prevention efforts.

Public Significance

Greater exposure to social adversity was associated with more disordered eating behaviors among preadolescent children. Given that eating disorders are understudied in lower‐income and minority racial/ethnic populations, this study highlights the need for additional research to better support prevention and treatment efforts among children from socioeconomically diverse backgrounds.
A practical application of methodologies to determine asset criticality and work order prioritization
Authors: English Lar , Yunusa‐Kaltungo Akilu
Published: July 2022

The ability of a company to prioritize work orders is an essential part of managing work which in turn is vital when it comes to delivering maintenance services. The authors have drafted a tutorial paper that outlines a real‐world application of practices which determine asset criticality and work order prioritization. The paper initially provides a background on the estate of the featured facilities department. An approach is then provided to determine asset criticality across an asset register which factors in the importance of each site in relation to the overall mission of the estate. The final step is to use asset criticality, work urgency and a time factor to address work order prioritization. If a company wishes to adopt the approach in this paper but does not possess a Computerized Maintenance Management System (CMMS) with the required functionality, they could instead utilize a spreadsheet‐based approach incorporating data exports from their resident CMMS. While this paper features data from the facilities management industry, the approach is agnostic and can be implemented by maintenance departments regardless of the industry.