bluuebunny/crossref_metadata_2025 huggingface dataset:
Joint-preserving procedures for osteonecrosis of the femoral head
Authors: Atilla Bülent , Bakırcıoğlu Sancar , Shope Alexander J. , Parvizi Javad
Published: December 2019

Osteonecrosis of the femoral head is a poorly understood condition that may lead to progressive destruction of the hip joint. Its incidence is common between the third and fifth decades of life and it is the diagnosis behind 5–18% of annually performed total hip arthroplasties (THAs) in the USA. Regarding the high rate of complications of THA in that age group, authors have agreed on the importance of joint-preservation techniques for this disease but techniques vary to establish a generally accepted algorithmic approach. Surgical head-preserving procedures, core decompression with or without graft, stem cell augmentation, or biologic adjuncts, vascularized bone grafting, and proximal femoral osteotomies have all been published on with heterogeneous results and with limited evidence to date. Consensus states that the prognosis of patients with osteonecrosis of the femoral head can be significantly improved with early diagnosis and timely intervention.

Cite this article: EFORT Open Rev 2019;4:647-658. DOI: 10.1302/2058-5241.4.180073
Soft tissue tumours of the elbow: current concepts
Authors: Savvidou Olga D. , Koutsouradis Panagiotis , Bolia Ioanna K. , Kaspiris Angelos , Chloros George D. , Papagelopoulos Panayiotis J.
Published: December 2019

Soft tissue tumours of the elbow are mostly benign. Malignant tumours in this area, although uncommon, often present unique clinical and histopathological characteristics that are helpful for diagnosis. Management of soft tissue tumours around the elbow may be challenging because of their rarity and the proximity to neurovascular structures. Careful staging, histological diagnosis and treatment are essential to optimize clinical outcome. A missed or delayed diagnosis or an improperly executed biopsy may have devastating consequences for the patient. This article reviews the most common benign and malignant soft tissue tumours of the elbow and discusses the clinicopathological findings, imaging features and current therapeutic concepts.

Cite this article: EFORT Open Rev 2019;4:668-677. DOI: 10.1302/2058-5241.4.190002
Campus USP Butantã: el conocimiento crítico y la ciudad
Authors: Sandoval Gregori Marcia , Guilherme Mota Carlos
Published: December 2019

El estudio tiene como objetivo determinar cómo la relación espacial de la Ciudad Universitária Armandobr /Salles de Oliveira (Campus Butantã de la Universidad de São Paulo) con la ciudad expresa una segregación que ahora presenta matices diferentes a la época de su creación. Concebida para ser una entidad autónoma, independiente, destinada al desarrollo del conocimiento, lejos del centro urbano, actualmente, con el crecimiento de la ciudad, se ha incorporado a la trama de São Paulo. Sin embargo, aún aparece como un espacio segregado de la ciudad, aunque con diversas interpenetraciones mutuas. La creación de la Ciudad Universitaria muestra la distinción del conocimiento universitario como la representación de una ciudad técnico-industrial y de un país desarrollado. Además de las formas físicas y espaciales, su ubicación, su disposición espacial y su relación con la ciudad expresan las representaciones de la sociedad, de las mentalidades. Hoy rodeada por la ciudad con todos sus problemas y peculiaridades, la Ciudad Universitaria exhibe una situación urbana que remite a algunas ideas “condominiales” como modo de aislarse del entorno. Con su propio estilo de vida, basado en un orden interno particular y en la convivencia entre semejantes, el campus Butantã USP, busca, por un lado, evitar los conflictos de la ciudad a su alrededor, al mismo tiempo que no puede evitar formar parte de ella. Es una invitación a reflexionar sobre las premisas y motivos de la concepción de ese formato, cómo se desarrolla y cuáles son sus marcas en la relación universidad-ciudad y universidad-sociedad.
El modernismo brasileño en la Vanguardia Latinoamericana
Authors: Milhanas Machado Hugo
Published: December 2019

Mendonça Teles, G. & Müller-Bergh, K. (Eds.). (2015). Vanguardia Latinoamericana. Historia, crítica y documentos [Tomo VI, Brasil]. Frankfurt am Main/Madrid: Vervuert/Iberoamericana.Después de la publicación de los volúmenes dedicados a las literaturas de México y América Central (Tomo I), Caraíbas, Antillas Mayores y Menores (Tomo II), América del Sur, Área andina Norte (Tomo III), América del Sur, Área andina Sur (Tomo IV) y América del Sur, Chile y países del Plata (Tomo V), la serie Vanguarda latino-americana. História, crítica e documentos dedica su sexto tomo (edición Vervuert e Iberoamericana, 2015), con autoría, coordinación y organización de Gilberto Mendonça Teles y Klaus Müller-Bergh, a la producción literaria brasileña en el ámbito de los modernismos novocentistas.
La migración de retorno a Brasil en el contexto de la crisis económica
Authors: Ribeiro De Oliveira Antônio Tadeu
Published: December 2019

La paradoja de la movilidad espacial de la población está presente en el modo de producción capitalista, ya en su fase primitiva. La crisis en el patrón de acumulación del capital, a fines de los años 1960 y principios de los 1970, y su paso a un patrón flexible, ha provocado una serie de transformaciones no solo en la economía, sino también en el modo de vida de las poblaciones. Ese nuevo modelo, cuya expresión política era el neoliberalismo, que dictaba el Estado mínimo, pasó a imponer barreras a la libre circulación de personas hacia los países del centro hegemónico. Treinta y pocos años después, la crisis económica iniciada en los países centrales, como prolongación y reflejo de los problemas no superados de la crisis anterior, acabó por generar una ola de retorno y re-emigraciones, pasando a figurar Brasil entre los países receptores de importantes volúmenes de migración de retorno. En ese sentido, el presente artículo abordará las relaciones entre los factores que provocaron tanto la salida como el retorno de los brasileños, así como, a través de los datos empíricos, identificar cómo fue la reinserción de los migrantes en Brasil, a partir de la localización geográfica y la reintegración en el mercado de trabajo.
Sistema sindical italiano: la evolución que le faltó a Brasil
Authors: Bonatto Barcellos Antonio Augusto , Zambrano Virginia
Published: December 2019

El presente trabajo trata sobre la constatación de la distinta evolución que tuvieron los sistemas sindicales brasileño e italiano durante el siglo XX. A partir de un modelo muy similar en el período anterior a la Segunda Guerra Mundial, Italia adoptó un sistema sindical que respetaba los postulados de libertad sindical plena. Incluso a pesar de todas las dificultadas causadas por la difícil adaptación de las relaciones de trabajo al nuevo sistema, Italia ya posee más de medio siglo de constantes cambios en busca del respeto a la libertad sindical. Brasil tarde o temprano tendrá que adoptar el mismo sistema y parece que la inspiración del modelo italiano le puede ser muy útil.
Presentación
Authors: Santos Pérez José Manuel , Beçak Rubens
Published: December 2019

Texto de presentación del número 5 (volumen 3) de la Revista de Estudios Brasileños.
Etnocirugías en Brasil: identidad, multiculturalismo y globalización
Authors: Masiero Luciana Maria
Published: December 2019

El objetivo de esta investigación es entender las transformaciones socioculturales generadas por lasbr tnocirugías a través de una reflexión sobre la identidad, el modelo multicultural y la globalización en Brasil. Este procedimiento quirúrgico es considerado un medio de integración de inmigrantes en las sociedades modernas, pues posibilita una homogeneización a través de la transformación de los rasgos étnicos distintivos. Por otro lado, también puede ser interpretado como una nueva forma de subordinación social y racismo. Es un estudio teórico de revisión bibliográfica con base en la antropología social y cultural.
P047 Do People With History of Inflammatory Disease Have a Higher Risk for Acute Coronary Syndrome
Authors: Al-Abboodi Yasir , Kubaissy Abdullah , Ali Ali Muhammed
Published: December 2019

BACKGROUND:

There is a debate if patients with history of inflammatory bowel disease (IBD) have higher risk of having acute coronary syndromes (ACS). Several studies have not answered this question. Our study used national data registry called the National Inpatient Sample (NIS) and the size of the target population is the largest sample used to answer the aforementioned question.

METHODS:

Retrospective analysis for the national inpatient sample data base (NIS). All diagnoses including IBD, ACS, Hypertension (HTN), Diabetes mellites (DM), Smoking, obesity, Alcohol abuse were identified using International Statistical Classification of Diseases and Related Health Problems (ICD9). A univariate and multivariate logistic regression analysis were used to calculate the Odd ratio. T test was used to examine the means. SPSS software version 24 was used for analysis.

RESULTS:

57984 admissions with history of inflammatory bowel disease (IBD) were identified using ICD9 codes. Of those, 7894 had Ulcerative colitis (UC), 40628 with Crohn’s, 414 (.0.7%) had acute coronary syndromes (ACS) related admissions. Mean age of patients is 50 plus. 25209 (43.5%) male, 32762 (56.5%) female. 47144 (81.3%) White, 5889 (10.2%) Black, 2941 (5.1%) Hispanic, 523 (0.9%) Asians, 1251 (2.2%) others. Mean length of stay for patient who had ACS related admissions and history of IBD is 5.4 days vs. 4.4 days for people without history of IBD (P = 0.08). A multivariate logistic regression showed that. Patients with history of IBD is less likely to have ACS(P < 000, Odd ratio(OR) = 0.73, 95% confidence interval (CI) = 0.0.669–0.0812 ), Smoking, (P < 0.05, OR = 1.569, 95% CI = 1.540–1.600), HTN (P < 0.005, OR = 2.732, 95% CI = 2.689–2.777), DM (P < 0.005, OR = 1.468, 95% CI = 0.428–1.508), Alcohol abuse (P < 0.05, OR = 0585, 95% CI = 0.56–0.611). There is no inpatient mortality difference between ACS related admission with history of IBD vs people with no history of IBD (P = 0.535, OR = 0.643, 95% CI = 1.60–2.588).

CONCLUSION(S):

People with inflammatory bowel disease do not have a higher risk for acute coronary syndrome. There is no mortality difference between ACS related admission with or without history of inflammatory bowel disease. ACS related admission with history of inflammatory bowel disease has a longer length of stay but not statistically significant.
P108 Serum Vedolizumab and Anti-Vedolizumab Antibody: Analysis of 6500 Patient Results Using Lab Developed Electrochemiluminescent Immunoassays (ECLIA)
Authors: Chun Kelly , Yang Jane
Published: December 2019

BACKGROUND:

Vedolizumab (VDZ), an anti- α4b7 integrin monoclonal antibody, is indicated for moderate to severe ulcerative colitis and Crohn’s disease. Therapeutic drug monitoring (TDM) assays to measure VDZ and anti-vedolizumab drug antibodies (ADAb) in patient serum are utilized to manage lack or loss of response and to proactively optimize dosing. Some studies suggest target induction trough concentrations >30 ug/mL and maintenance troughs > 14 ug/mL (1,2). Here, 6500 VDZ patient results were analyzed.

METHODS:

Measurements of VDZ drug (free, ADAb-unbound) and anti-vedolizumab antibody (total including IgM and IgG subtypes) were performed by lab-developed ECLIA. Lower limits of quantitation are 1.5 ug/mL for VDZ and 25 ng/mL for ADAb. All ADAb positive samples are confirmed by a signal suppression test. Clinical histories and blood collection timing are unknown.

RESULTS:

Of 6500 measured samples, 98.9% (6426) were ADAb-free and only 1.1% (74) had measurable anti-vedolizumab antibodies. Since VDZ TDM was launched in January 2017, volumes have been increasing rapidly. In the absence of ADAb, the median VDZ concentration was 16.0 ug/mL with a range of 1.5 to 389 ug/mL. The distribution of 6426 VDC concentration measurements was as follows: 4.5% of patient samples had undetectable VDZ (<1.5 ug/mL) and 14.3% were less than 5.0 ug/mL. Of note, almost half of all VDZ concentrations (48.3%, 3101 or 6426) were less than 15 ug/mL. Only 30.6% (1966) of measured concentrations fell between 15 and 30 ug/mL, and 21.1% (1358) were greater than 30 ug/mL. Only 74 of 6500 samples had measurable anti-vedolizumab antibodies ranging in titer from 25 to 18,556 ng/mL. In the presence of high ADAb titers (>1000 ng/mL), concomitant VDZ drug levels were very low or undetectable (mean < 1.5 ug/mL, ranging from <1.5 to 8.8). In the setting of intermediate (100 - 1000 ng/mL) and low (<100 ng/mL) titers, the concomitant free drug mean was 6.9 and 16.1 ug/mL, respectively.

CONCLUSION(S):

Here, 6500 samples for VDZ monitoring were analyzed. The immunogenicity rate was low at 1.1%. Of our 6426 ADAb negative samples, ∼ 30% had VDZ levels 15 – 30 ug/mL and ∼20% were above 30 ug/mL. Interestingly, almost half (48.3%) of all VDZ measurements were less than 15 ug/mL. If 15 is considered a therapeutic cutoff, these findings may indicate a significant incidence of subtherapeutic VDZ. Despite the lack of firmly established targets, gastroenterologists are increasingly using TDM during both induction and maintenance to assess vedolizumab exposure.
Soil biomass and microbial activity in soybean crop area under different cover crops and different soil correction systems
Authors: Diniz Jéssica Ferreira , Roque Cassiano Garcia , Borges Monica Cristina Rezende Zuffo , Barros Pedro Paulo Vilela , Chagas Paulo Henrique Menezes das , Godinho Othon Lauar , Teodoro Paulo Eduardo
Published: December 2019

The objective of this work was to evaluate soil biomass and microbial activity and soybean yield under different limestone and gypsum doses and different cover crops. The experiment was carried out in the experimental area of ​​the Fundação de Apoio a Pesquisa Agropecuária de Chapadão, on a Dystrophic Red Latosol, using cultivar Desafio. The experiment consisted of a randomized blocks design, in a split-plot factorial scheme (3x4x3), with three replications. Plots consisted of three gypsum doses: control (without gypsum), recommended dose (2.3 Mg ha-1), and double dose (4.6 Mg ha-1). Subplots consisted of four limestone doses (2, 4, and 6 Mg ha-1) and the control (without limestone). Each block had three different cover crops: Brachiaria, Millet, and allow. The values obtained with the test revealed that brachiaria had better basal respiration in the absence of gypsum. Conversely, millet had better basal respiration in with the gypsum dose. Basal respiration, using brachiaria as cover crop, was higher at the dose of 2700 kg ha-1 of limestone. However, for the fallow and the millet, basal respiration was higher when using the highest limestone dose of 6000 kg ha-1. The variable microbial biomass showed differences between cover crops only in the absence of gypsum. Brachiaria and fallow presented the highest mean for microbial biomass. The use of millet as a cover crop together with gypsum doses increased the microbial biomass. The variables mass of 100 grains and grain yield had higher mean at the limestone dose of 6000 kg ha-1 .
Fertilization with liquid swine manure increases productivity and improves the quality of Urochloa decumbens
Authors: Pereira Vanderley José , Assis Daniel Ferreira de , Lana Regina Maria  Quintão , Silva Adriane de Andrade , Pereira Hamilton Seron
Published: December 2019

This study aims at assessing the influence of mineral fertilization and biofertilizer from liquid swine manure (LSM) in productivity, levels of crude protein (CP), neutral detergent fiber (NDF) and Acid Detergent Fiber (ADF) of Urochloa decumbens. The experiment was carried out in a red Latosol under a Urochloa decumbens pasture, in a state of degradation with loss of vigor and forage productivity. The delineation chosen for this study was randomized blocks with six treatments (control without fertilization, control with use of mineral fertilizer and four unique concentrations of liquid swine manure biofertilizer (61 m3 ha-1, 121 m3 ha-1, 181 m3 ha-1, 241 m3 ha-1)). The application of residue has been split in two times on the surface of the soil, by means of a distributor of liquid waste with a fan-shaped application. Yield and bromatological features were evaluated for two years. Fertilization with LSM can fully replace mineral fertilizing in Urochloa decumbens pasture systems, resulting in an increase, as a result, in the dry mass yield from the dosage of 121 m3 ha-1 and the reduction in fiber content in neutral and acid detergent. The increments in yield were observed in the second year, while improvement in bromatological quality was observed from the first application of LSM.
O uso de Realidade Virtual, Aumentada e Misturada no Jornalismo Impresso Brasileiro
Authors: Falco Alessandra de , Reis Silvia Cristina dos
Published: December 2019

A presente pesquisa traz os resultados da análise realizada nos jornais Estadão, O Globo e na revista Veja no mês de outubro de 2015 e maio e junho de 2016, sobre o uso de Realidade Virtual, Aumentada e Misturada como técnicas empregadas para ampliar o conteúdo do jornalismo impresso. Foi investigado como os veículos citados se utilizaram desse recurso nas suas versões impressas. A análise mostrou que, nos veículos em questão, os usos de conteúdos usando a técnica da Realidade Virtual, Aumentada e Misturada não explora suas potencialidades, como por exemplo, atualizar o conteúdo impresso com dados novos, ou é inexistente.
Publicidade e Infância: a influência dos jingles dos anos 80 e 90
Authors: Vailati André Luiz , Moura Camila Bergonci
Published: December 2019

A publicidade em forma de música ilustra sonoramente produtos e serviços de forma alegre e descontraída. Os jingles publicitários, na sua essência, possuem letras e melodias simples para que sejam facilmente memorizadas e reverberarem no inconsciente das pessoas. Diante disso, este trabalho tem como objetivo analisar a percepção de pessoas nascidas nas décadas de 1970 e 1980 em relação aos jingles das décadas de 1980 e 1990. Em uma pesquisa de campo de viés descritivo com uma abordagem qualitativa, foram utilizados autores das áreas da publicidade e sociologia para compor o arcabouço teórico. Os resultados revelaram que os jingles trazem consigo mais do que uma finalidade exclusivamente persuasiva, mas também um significativo impacto emocional, perdurando de forma singular na memória dos consumidores.
Comparación de métodos de extracción de ADN simples y económicos para el diagnóstico molecular de leptospirosis animal
Authors: HAMER Micaela , SARAULLO Vanina , BRIHUEGA Bibiana , WATANAVE Olivia , MARTINEZ Mara , GRUNE LOFFLER Sylvia
Published: December 2019

La leptospirosis bovina es una importante enfermedad zoonótica cuyo diagnóstico molecular está ampliamente divulgado. Sin embargo, no existe un método único de extracción de ADN para leptospiras patógenas a partir de muestras clínicas. En este trabajo se utilizó orina bovina contaminada con cultivo de L. interrogans serovar Pomona Pomona para analizar el mejor método comparando: M1.) resina Chelex-100, M2.) papel FTA Whatman y M3.) hervido de la muestra (protocolo casero). De estas tres técnicas, la primera (M1) presentó la mayor sensibilidad al realizar la PCR de diagnóstico, detectándose hasta 2x102 leptospiras/mL. La metodología aquí planteada resultó tener buen rendimiento para la detección de leptospiras en muestras clínicas animales, aunque es necesario su validación con mayor número y diversidad de muestras.
Adaptação do Questionário da Relação de Supervisão (versão reduzida) – Versão supervisando (QRS-r-supervisando)
Authors: Nogueira Rita Santos , Silva Ana Catarina Nunes , Conceição Nuno
Published: December 2019

O objectivo principal desta investigação foi a adaptação para a população portuguesa do Questionário da Relação de Supervisão (versão reduzida) – versão supervisando (QRS-r-supervisando). A importância deste constructo na satisfação com a supervisão, no desenvolvimento do terapeuta e na eficácia terapêutica motivaram esta investigação. Realizou-se uma tradução do questionário, seguida de retroversão e de um pré-teste a um pequeno grupo de estudantes de Psicologia, em supervisão. Posteriormente procedeu-se com a investigação recrutando-se 90 psicólogos clínicos/psicoterapeutas em supervisão. Aplicou-se também o Questionário Revisto de Personalidade de Eysenck (adaptação Almiro & Simões, 2013) para efeitos de validade divergente e o CASES (adaptação Lamares & Conceição, 2012) para efeitos de validade preditiva. Os resultados, a partir da análise factorial, sugerem uma medida composta por 17 itens divididos pelas mesmas três subescalas da medida original (Base Segura, Educação Reflexiva e Estrutura) e propriedades psicométricas adequadas (validade factorial, fiabilidade compósita e validade divergente). Discute-se a utilidade da medida e o seu valor prático bem como aspectos para futuras investigações.
Estilos parentais e comportamentos de bullyingem adolescentes e jovens adultos: Efeito moderador da personalidade
Authors: Mota Catarina Pinheiro , Costa Mónica , Pinheiro Mónica , Nunes Filipa
Published: December 2019

Os estilos parentais caracterizam a natureza afetiva e a relação entre os pais e os filhos, apresentando por isso, uma contribuição importante para o desenvolvimento psicossocial dos jovens. A vivência familiar, a relação mantida com os pares e o desenvolvimento do adolescente contribuem para a formação da sua personalidade, sendo esta que dita muitos dos comportamentos futuros dos adolescentes e jovens adultos. Este estudo teve como objetivo analisar o papel dos estilos parentais e da personalidade no desenvolvimento de comportamentos de agressão e vitimação, assim como, testar o papel moderador da personalidade na associação anterior. A amostra foi constituída por 1976 adolescentes e jovens adultos, com idades compreendidas entre os 14 e os 25 anos de idade (M=17.22; DP=2.50). A recolha de dados foi realizada com recurso a instrumentos de autorrelato. Os resultados sugerem a extroversão e a conscienciosidade como fatores protetores face ao desenvolvimento de comportamentos de vitimação e agressão, e o neuroticismo como um importante potenciador destes comportamentos. Os dados foram analisados à luz da teoria de Baumrind, assumindo a importância dos estilos parentais para o desenvolvimento da personalidade e de comportamentos de bullying na adolescência e jovem adultícia.
Formas de intervención psicosocial para familias que consultan por temas de crianza
Authors: Rivera Ovidio Herrera , Bedoya Cardona Ledy Maryory , Mendoza Adriana María Coronado
Published: December 2019

El artículo resalta el interés por identificar las formas de intervención de los profesionales psicosociales que trabajan actualmente con familias consultantes en el tema de crianza. Para ello, se hizo un acercamiento a 16 profesionales expertos en este tipo de abordajes. En este sentido, se tuvo por objeto conocer las formas, estrategias y técnicas adoptadas por profesionales en el proceso de intervención en crianza, así como también los motivos de consulta que llevan a los padres a solicitar apoyo profesional. El enfoque del estudio es cualitativo, al favorecer aspectos descriptivos e interpretativos acordes a los objetivos propuestos, con apropiación del análisis de contenido (AC) como metodología de trabajo. Los resultados colocan en reflexión y análisis las técnicas y estrategias que utilizan los profesionales en sus intervenciones en el tema de crianza; en correspondencia a su fundamentación teórica y metodológica.
Molecular Docking Study of Akar Kuning (Arcangelisia flava) Secondary Metabolites as Src Inhibitor
Authors: Pratama Mohammad Rizki Fadhil , Mulyani Evi , Suratno Suratno
Published: December 2019

Proto-oncogene tyrosine-protein kinase Src is also known as simply Src is a tyrosine kinase protein which is one of the targets in various cancer therapies such as leukemia. Meanwhile, akar kuning (Arcangelisia flava) has gained significant attention as a medicinal plant that has a cytotoxic effect on various types of cancer cells. This study aims to determine the potential of secondary metabolites of akar kuning as Src inhibitors. Molecular docking was carried out using Autodock Vina 1.1.2 with 2HCK receptors, that quercetin and dasatinib were used as reference ligands. The docking results showed that the highest affinity was shown by berberine with a ΔG value of -9.0 kcal/mol, exceeded quercetin and dasatinib. However, the highest amino acid similarity to quercetin and dasatinib was produced by jatrorrhizine, with 93.33% and 73.91%, respectively. Interestingly, berberine is the ligand with the third-highest similarity after jatrorrhizine and palmatine, while jatrorrhizine has the second-highest affinity after berberine. The results concluded that the combination of berberine and jatrorrhizine is predicted to be optimally used as an Src inhibitor in cancer therapy.
The Effect of Cu Ohmic Contact on Photoelectrochemical Property of S-CuO Thin Film Photocathodes
Authors: Amrullah Aziz , Gunawan Gunawan , Prasetya Nor Basid Adiwibawa
Published: December 2019

The development of semiconductor materials as photocathodes that have excellent performance is significant for the photoelectrochemical reaction of hydrogen evolution. The thin film of sulfur-doped Copper (II) oxide (S-CuO)  was successfully synthesized using the cyclic voltammetry method. Investigation of photoelectrochemical properties of S-CuO photocathodes, including current density, onset potential, applied photon to current efficiency (ABPE), and bandgap had been carried out. It was reported that the Cu ohmic contact affected the photoelectrochemical properties and the stability of the thin film. The presence of Cu ohmic contact can improve the performance of S-CuO thin film photocathodes. The S-CuO TU 20 mM thin film has the best response with a current density of -0.923 mA/cm2, an onset potential of 0.59 V, and ABPE of 0.21%. Stability occurred at pH 7 in 0.2M NaH2PO4. The optical analysis showed S-CuO TU 20 mM bandgap of 1.7 eV.
Detektion von Anomalien zur Qualitätssicherung basierend auf Sequence-to-Sequence LSTM Netzen
Authors: Lindemann Benjamin , Jazdi Nasser , Weyrich Michael
Published: December 2019

Unvorhersehbare Prozessereignisse und Anomalien sind Treiber erhöhter Ineffizienzen in Form von schwankender Produktqualität. In diesem Beitrag wird ein datengetriebener Ansatz zur Qualitätsoptimierung vorgestellt, auf dessen Basis Anomalien charakterisiert werden, die zur Entwurfszeit des Systems nicht bekannt waren. Es wird eine Netzarchitektur in Form eines Sequence-to-Sequence Netzes mit Long Short-Term Memory (LSTM) Zellen vorgestellt. Dadurch kann vorhergesagt werden, welche Anpassung am Stellgrößenverhalten vorgenommen werden muss, um erwartete Anomalien zu kompensieren. Dadurch wird das Qualitätsergebnis langfristig in der Toleranz gehalten. Der Ansatz wird prototypisch anhand von zwei Prozessketten der diskreten Fertigung umgesetzt und evaluiert.
The Challenge of Organizing Elderly Care Programmes: Optimal Policy Design under Complete and Asymmetric Information
Authors: Leporatti Lucia , Montefiori Marcello
Published: December 2019

The increasing life expectancy poses challenges on the future sustainability of long-term care services that today strongly depend on informal care provided within the family by working age children. Ongoing social changes are likely to weaken the informal provision of care. The paper derives optimal policies to help the policy-maker to choose innovative and sustainable solutions to support home care, taking into account the severity of health condition and the different opportunity costs of carers. Drawing inspiration from real world policies, the suitable policy combines lump-sum transfers, paid permissions from work and in-kind provisions. In some circumstances, benefits can favour higher rather than lower income individuals. In the context of information asymmetry, the implementation of the second-best outcome requires the level of care of the most subsidized households’ to be forced towards certain targets to avoid adverse selection.
Wireless power transmission in endoscopy capsules
Authors: Kühne Michael , Andrä Wilfried , Werner Christoph , Bellemann Matthias E.
Published: December 2019

The operating life of endoscopy capsules is limited by the batteries needed for use. The capacity of corresponding batteries, however, is too short to cover the total period of gastrointestinal transit. To overcome this limitation, a novel kind of wireless power transmission was used. It utilizes a permanent magnetic cylinder located outside the patient’s body and is turned by an electric motor, thereby generating a rotating magnetic field. This field in turn causes the motor, by a permanent magnetic sphere, located in a liquid bearing inside the endoscopy capsule, to rotate synchronously. The sphere induces an alternating voltage in coils inside the capsule and thus provides the necessary power. This arrangement was able to transmit power of up to 170 mW. This value is clearly higher than the minimum power of 100 mW needed to operate the electronics of the endoscopy capsules that are actually in use. The volume of both the sphere and the induction coil is smaller than the batteries that are actually integrated in the capsules. By this means, the operating time may be prolonged, in principle up to arbitrary values.
Synthesis and crystal structure of benzyl 5-oxo-5-phenyl-2-(quinolin-2-yl)pentanoate, C27H23NO3
Authors: Wang Li , An Xiao-Xin , Cui Yong-Fan , Dong Wen-Kui
Published: December 2019

C27H23NO3, monoclinic, P21 (no. 4), a = 5.8236(4) Å, b = 16.7277(13) Å, c = 10.5963(7) Å, β = 96.022(2)°, V = 1026.55(13) Å3, Z = 2, R
gt(F) = 0.0396, wR
ref(F
2) = 0.0953, T = 153(2) K.
Age-Related Changes of Some Chemical Components in the Leaves of Oriental Beech (Fagus orientalis Lipsky.)
Authors: Turfan Nezahat , Ayan Sezgin , Nurten Yer Esra , Barış Özel Halil
Published: December 2019

Background and Purpose: This study presents the analysis of photosynthetic pigments, proline, total soluble protein, total amino acids, glucose, sucrose, total soluble sugars, total amount of phenolic compounds and flavonoids, malondialdehyde (MDA) and hydrogen peroxide (H2O2) concentration in the leaf samples collected from oriental beech trees, which are naturally spread in Kastamonu Province, Turkey, with differing ages, enzyme activities of ascorbate peroxidase (APX), catalase (CAT) and superoxide dismutase (SOD).
Material and Methods: The research was carried out on oriental beech trees (Fagus orientalis L.) of different ages located at 1300 m high elevation in Ahlat Village of Kastamonu Province, Turkey. Oriental beech trees of different ages (≥25, ≥50, ≥100, ≥200 and ≥600 years-old) constituted the material of this study. In leaf samples taken from trees of different ages, photosynthetic pigments (chlorophyll a, chlorophyll b, total chlorophyll and carotenoid), proline, total soluble protein, total amino acid, glucose, sucrose, total soluble sugars, the amount of total phenolic compounds and flavonoids, MDA, H2O2 concentration, enzyme activities of APX, CAT and SOD, as well as the relationship between the total content of C, N and H elements and the tree ages were studied.
Results: As a result of the research conducted, significant differences were determined in terms of chlorophyll, total phenolic compound, flavonoid, glucose, amounts of sucrose, nitrogenous compounds, proline, total soluble protein, MDA, H 2O2 concentrations, and the activities of APX, CAT and SOD in the leaves of oriental beech trees with differing ages. The highest content of chlorophyll a was found to be in the youngest age group of ≥25 years. Total chlorophyll is low in young trees and high in middle-aged, old and very old trees. According to the results obtained, it was concluded that the MDA and H2O2 concentrations in the trees did not vary depending on the age of trees only, but also on the genotype, environmental conditions and metabolic activities. It was concluded that the fact that the total chlorophyll, phenolic compounds and sucrose content in oriental beech trees are high and that MDA content is low could have an influence on the long life of ≥600 years-old oriental beech trees.
Conclusions: The activity of photosynthesis is related to leaf characteristics more than the age of trees.
New Silvicultural Treatments for Conifer Peri-Urban Forests Having Broadleaves in the Understory - The First Application in the Peri-Urban of Xanthi in Northeastern Greece
Authors: Milios Elias , Kitikidou Kyriaki , Radoglou Kalliopi
Published: December 2019

Background and Purpose: In Greece, forest practice did not develop special silvicultural treatments for planted conifer peri-urban forests where broadleaf trees appear as natural regeneration in the understory. The aims of this study are: a) to analyze the new proposed selective silvicultural treatments for the planted peri-urban forest of Xanthi and for analogous planted conifer forests, where broadleaf trees are naturally established in the understory b) to check the research hypothesis that the new selective silvicultural treatments exhibited higher intensity in terms of the basal area of cut trees, compared to that of traditional treatments in the studied peri-urban forest.
Materials and Methods: In the traditional treatments, in the pine overstory cuttings, apart from the dead trees, mainly the malformed, damaged, suppressed and intermediate trees were cut. In the lower stories, the goal of the thinning was the more or less uniform distribution of broadleaf trees. In the proposed selective treatments, the main aim of pine cuttings is to release the broadleaf formations growing in the lower stories, while the treatments of the broadleaf trees will be a form of “positive selection” thinning. Plots were established in areas where the two types of treatments were going to be applied. In each plot, tree measurements and a classification of living trees into crown classes took place. After the application of the treatments the characteristics of cut trees were recorded.
Results: In the established plots, before the cuttings (and thinning), total basal area was not statistically significantly different between the two types of treatments. In selective treatments, the basal area of all cut trees was statistically significantly higher than that of the results of traditional treatments. In the broadleaf cut trees there were statistical differences in the ratios of dominant, intermediate and suppressed trees between the two silvicultural approaches.
Conclusions: The research hypothesis was verified. The intensity of treatments in terms of the basal area of cut trees was higher in the selective approach, compared to the traditional treatments in the Xanthi peri-urban forest. However, the overstory cutting intensity of the selective treatments depends on the spatial distributions and densities of broadleaved and conifer trees. In the broadleaf trees, the different objectives of the two types of treatments resulted in thinning with different qualitative characteristics. The proposed silvicultural treatments will accelerate the conversion of peri-urban conifer forests having an understory of broadleaf trees into broadleaved forests, or into mixed forests of conifers and broadleaf trees.
Widespread Distribution of the Sycamore Seed Bug Belonochilus numenius (Hemiptera: Heteroptera: Lygaeidae) Throughout the Republic of North Macedonia
Authors: Srebrova Katerina , Nacheski Sterja , Sotirovski Kiril
Published: December 2019

Background and Purpose: The sycamore seed bug, Belonochilus numenius (Say, 1831), was recorded for the first time in Europe in 2008, with finds in that same year in two separate locations in Spain and two in France. Since then, it has been reported to be present in 17 European countries. Once it reached Europe, the fast spread and establishment of this species was facilitated both by the increased plant trade and the relative frequency of plane trees ( Platanus x acerifolia, P. orientalis and P. occidentalis ) planted on a wide scale across the continent due to their popularity as urban and peri-urban trees.
Materials and Methods: In the summer of 2019 we inspected urban, peri-urban and natural populations and groups of plane trees throughout North Macedonia, on a total of 44 sites, looking for presence of nymphs and adults of this insect on seed balls. We collected specimens and related data and made identification based on specific external characteristics typical of B. numenius.
Results: We report the first record of B. numenius in the Republic of North Macedonia from July 2019, from P. x acerifolia in Skopje. Furthermore, after inspecting plane trees throughout the country we report the presence of this insect in 29 cities and towns, 3 peri-urban and in 1 natural population of P. orientalis.
Conclusions: From the widespread distribution of this insect species, we conclude that it has entered the territory of North Macedonia many years prior, very likely soon after first records in Serbia in 2011 and Bulgaria in 2012, but has since been overlooked.
Characterization of Embryonic Skin Transcriptome in Anser cygnoides at Three Feather Follicles Developmental Stages
Authors: Liu Chang , Sello Cornelius Tlotliso , Sui Yujian , Hu Jingtao , Chen Shaokang , Msuthwana Petunia , Zhou Yuxuan , Wachiebine Sulleyman Kassim , Sun Yue , Liu Jing , Li Shengyi , Yang Wei , Song Yupu , Xu Yunpeng , Guo Chanying , Sui Qihui , Sun Yongfeng
Published: December 2019

In order to enrich the Anser cygnoides genome and identify the gene expression profiles of primary and secondary feather follicles development, de novo transcriptome assembly of skin tissues was established by analyzing three developmental stages at embryonic day 14, 18, and 28 (E14, E18, E28). Sequencing output generated 436,730,608 clean reads from nine libraries and de novo assembled into 56,301 unigenes. There were 2,298, 9,423 and 12,559 unigenes showing differential expression in three stages respectively. Furthermore, differentially expressed genes (DEGs) were functionally classified according to genes ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and series-cluster analysis. Relevant specific GO terms such as epithelium development, regulation of keratinocyte proliferation, morphogenesis of an epithelium were identified. In all, 15,144 DEGs were clustered into eight profiles with distinct expression patterns and 2,424 DEGs were assigned to 198 KEGG pathways. Skin development related pathways (mitogen-activated protein kinase signaling pathway, extra-cellular matrix -receptor interaction, Wingless-type signaling pathway) and genes (delta like canonical Notch ligand 1, fibroblast growth factor 2, Snail family transcriptional repressor 2, bone morphogenetic protein 6, polo like kinase 1) were identified, and eight DEGs were selected to verify the reliability of transcriptome results by real-time quantitative PCR. The findings of this study will provide the key insights into the complicated molecular mechanism and breeding techniques underlying the developmental characteristics of skin and feather follicles in Anser cygnoides.
The Alliance of Genome Resources: Building a Modern Data Ecosystem for Model Organism Databases
Authors:   The Alliance of Genome Resources Consortium
Published: December 2019

Model organisms are essential experimental platforms for discovering gene functions, defining protein and genetic networks, uncovering functional consequences of human genome variation, and for modeling human disease. For decades, researchers who use model organisms have relied on Model Organism Databases (MODs) and the Gene Ontology Consortium (GOC) for expertly curated annotations, and for access to integrated genomic and biological information obtained from the scientific literature and public data archives. Through the development and enforcement of data and semantic standards, these genome resources provide rapid access to the collected knowledge of model organisms in human readable and computation-ready formats that would otherwise require countless hours for individual researchers to assemble on their own. Since their inception, the MODs for the predominant biomedical model organisms [Mus sp. (laboratory mouse), Saccharomyces cerevisiae, Drosophila melanogaster, Caenorhabditis elegans, Danio rerio, and Rattus norvegicus] along with the GOC have operated as a network of independent, highly collaborative genome resources. In 2016, these six MODs and the GOC joined forces as the Alliance of Genome Resources (the Alliance). By implementing shared programmatic access methods and data-specific web pages with a unified “look and feel,” the Alliance is tackling barriers that have limited the ability of researchers to easily compare common data types and annotations across model organisms. To adapt to the rapidly changing landscape for evaluating and funding core data resources, the Alliance is building a modern, extensible, and operationally efficient “knowledge commons” for model organisms using shared, modular infrastructure.
Comunicar malas noticias en medicina
Authors: Enríquez-Quispe José Alfredo , Mendoza-Guillen Sofía Diana , Moya-Salazar Jeel
Published: December 2019

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Características clínicas y mortalidad intrahospitalaria en pacientes con insuficiencia renal aguda en hemodiálisis, en el Hospital Nacional Guillermo Almenara Irigoyen, EsSalud, 2014-2015
Authors: Fernandez-Burga Antonio , Briceño-Santillan Kristhian , Mejia Christian R.
Published: December 2019

Introducción: No existen datos oficiales sobre los pacientes con insuficiencia renal aguda (IRA) en el Perú. La mayor parte de la información proviene de centros aislados en otros países. Objetivo: Describir las características clínicas y la mortalidad intrahospitalaria en pacientes con insuficiencia renal aguda, en hemodiálisis, atendidos en un hospital de tercer nivel del Perú. Método: Estudio transversal, realizado en pacientes con diagnóstico de IRA en hemodiálisis, atendidos en el Hospital Guillermo Almenara Irigoyen, EsSalud, durante 2014-2015. Se evaluaron las características clínicas generales y se estimó la tasa de mortalidad intrahospitalaria. Resultados: Se evaluaron 183 pacientes. La edad media fue de 58 años y el 57% fueron varones. El 90% ingresaron al hospital a través de emergencia (EMG). Los pacientes fueron admitidos en la unidad de cuidados intensivos (UCI), EMG y otras áreas de hospitalización en el 40%, 27% y 33% de los casos, respectivamente. Las causas más frecuentes de IRA fueron: sepsis (59%), insuficiencia cardíaca (8%) y uropatía obstructiva (7%). La mortalidad intrahospitalaria fue de 55% (n=100). Los pacientes fallecidos mostraron una mayor frecuencia de sepsis (71 vs. 38; p = 0,001) y de compromiso multiorgánico (90 vs. 56; p < 0,001) en comparación con los vivos. Conclusiones: Los pacientes con IRA tuvieron una edad media de 59 años y la mayoría estuvieron hospitalizados en UCI. La causa más frecuente de IRA fue la sepsis. La mortalidad intrahospitalaria fue 55% y estuvo significativamente asociada a la presencia de sepsis y compromiso multiorgánico.
Frecuencia de trastornos musculoesqueléticos en los trabajadores de una refinería de Lima, 2017
Authors: Ramírez-Pozo Egle Guisela , Montalvo Luna Mery
Published: December 2019

Introducción: Se estima que los trastornos musculoesqueléticos representan la patología más frecuente en trabajadores y es la causa de mayor cantidad de días no laborados por incapacidad. Objetivo: Determinar la frecuencia de trastornos musculoesqueléticos en los trabajadores de una refinería de Lima durante el año 2017. Métodos: Estudio transversal. Se realizó la revisión de las historias clínicas ocupacionales de los trabajadores para obtener los datos demográficos y el registro donde se emitió el diagnóstico de trastorno musculoesquelético en base a los resultados de pruebas de imagen y de la evaluación clínica realizada por un especialista. Resultados: La muestra incluyó a 223 trabajadores y se encontró una frecuencia de trastornos musculoesqueléticos del 52,9%. Los más frecuentes fueron: lumbago asociado a hernia discal (25,1%), lumbago (13%), síndrome del manguito rotador (10,3%) y cervicalgia asociada a hernia discal (3,6%). Conclusiones: Se encuentra en esta población una elevada prevalencia de trastornos musculoesqueléticos en tronco y extremidades superiores.
Fístula bronquioesofágica asociada a reflujo gastroesofágico
Authors: Padilla Flores Juan Roberto , Lira Villasante Daniel Alcides , Victorio Avila Cesar Antonio , Quispe Huachaca Jhonathan Percy
Published: December 2019

Se presenta un caso clínico demostrativo de fistula broncoesofágica asociado a reflujo gastroesofágico en un varón de 76 años con diagnóstico de reflujo gastroesofágico y hernia hiatal, que acude por episodios de tos de 1 año de evolución sin respuesta a tratamientos. Demostraremos la utilidad del estudio esofagográfico como elemento diagnóstico. Se revisa brevemente los aspectos clínicos, diagnósticos, terapéuticos y probable secuencia de desarrollo de esta complicación.
Estrategias para promover la alfabetización en salud desde la atención primaria: una perspectiva que considera las realidades de los países de ingresos medios y bajos
Authors: Málaga German , Cuba-Fuentes María Sofía , Rojas-Mezarina Leonardo , Romero-Albino Zoila , Hamb Alexandra , Paz-Soldán Valerie A.
Published: December 2019

La alfabetización en salud se asocia con mejores resultados de salud. Los profesionales de salud de atención primaria generalmente brindan la mayor parte de la atención a los pacientes y también suelen ser el primer punto de contacto para los pacientes dentro de un sistema de salud. En este artículo se discuten cuatro estrategias para promover la alfabetización en salud en el entorno de atención primaria: 1) Mejorar las habilidades de comunicación del clínico, 2) Usar herramientas de e-Salud, 3) Promover el autocuidado del paciente, y 4) Desarrollar sistemas de apoyo y entornos de cuidado. Estas estrategias se discuten en el contexto de las realidades de los países de ingresos medios y bajos, como el caso de Perú.
El abordaje temprano y tratamiento mixto en el manejo de la esquizofrenia
Authors: Vílchez Salcedo Luis Arturo , Turco Arévalo Elena , Varillas Marín Rudy Ángel , Salgado Valenzuela Carlos Alexis , Salazar de la Cruz Miriam , Carmona Clavijo Gloria , Huamán Sánchez Karen , Bonilla Untiveros Catherine , Reyes Puma Nora , Caballero Ñopo Patricia
Published: December 2019

Introducción: La esquizofrenia es un trastorno psicótico caracterizado por alteración sustantiva del funcionamiento mental y efectos sobre la funcionalidad social de la persona afectada. Objetivo: Brindar recomendaciones basadas en la mejor evidencia disponible para abordaje temprano, tratamiento farmacológico y psicosocial. Métodos: Se elaboró una guía de práctica clínica basada en evidencias (GPC-BE), adaptada mediante proceso sistemático, riguroso, transparente, desarrollado por un grupo elaborador integrado por metodólogos y psiquiatras expertos en el manejo de esquizofrenia. La guía comprende cuatro preguntas clínicas y recomendaciones, se realizó búsqueda de guías que respondan al tema priorizado, se preseleccionaron y evaluaron guías mediante el instrumento “Appraisal of Guidelines for Research and Evaluation II” (AGREE-II), la de mejor calidad metodológica fue elegida para adaptación. La búsqueda sistemática de evidencias para cada pregunta clínica fue realizada en múltiples bases de datos: MEDLINE/Ovid, EMBASE/Ovid, EMB reviews/Ovid. La selección y análisis de evidencias se realizó mediante pares clínicos y metodológos, las recomendaciones fueron elaboradas aplicando metodología Grading of Recommendations Assessment, Development, and Evaluation (GRADE). Resultados: Con participación del panel de expertos clínicos de institutos y hospitales del Perú referentes en el manejo de esquizofrenia, se elaboraron cuatro recomendaciones para la intervención temprana, tratamiento farmacológico y mixto de pacientes adultos con esquizofrenia. Conclusiones: Se recomienda el abordaje temprano del primer episodio psicótico a través de centros de salud mental comunitarios (CSMC) y hospitales especializados y tratamiento farmacológico junto a terapia psicosocial estandarizada. El presente artículo resume la guía de práctica clínica basada en evidencias elaborada por un hospital público peruano especializado en salud mental.