bluuebunny/crossref_metadata_2025 huggingface dataset:
Multidimensional Assessment of Student Mental Health during the COVID-19 Pandemic: A Latent Profile Analysis Integrating Positive Psychology
Authors: Guelmami Noomen , Saidane Mouna , Ben Aissa Mohamed , Rebhi Mahmoud , Chalghaf Nasr , Azaiez Fairouz , Bragazzi Nicola Luigi , Dergaa Ismail
Published: December 2023

Background: The mental health of young adults, especially university students, has become an increasingly concerning issue. In order to develop targeted interventions and support initiatives, it is essential to comprehend distinct mental health profiles and identify vulnerable groups among Tunisian university students. This study aimed to achieve three main objectives: (a) to empirically identify different profiles of mental health among young adults in Tunisia, based on a person-centred approach using the dual-factor model of mental health, (b) to outline the identified profiles, which incorporate both psychopathological symptoms and indicators of positive subjective well-being, across sociodemographic and academic achievement factors, and (c) to establish predictors of these profiles.Methods: Cross-sectional data was collected from a cohort of teenage Tunisian university students (n = 1185, 54% females), aged between 18 to 24 years old (Mean = 21.10; SD = 2.02). Participants completed an online survey, which included assessments of socio-demographic characteristics, academic achievement, stress, depression, anxiety, spiritual well-being, life satisfaction, and happiness.Results: Analysis of latent profiles revealed the existence of three distinct mental health classes. The first profile (21.1%) represented individuals with poor mental health. The second profile (42.5%) consisted of individuals with moderate mental health, and the third profile (36.4%) comprised individuals with good mental health. Significant differences were found between these three classes regarding family income and academic completion (p<0.01 and p<0.001, respectively). Multinomial logistic regression analysis provided Odds Ratios (OR) with Confidence Intervals (CI), revealing that the poor mental health class was associated with low family income (OR: 3.28; 95% CI: 1.90–5.63) and failed academic achievement (OR: 46; 68% CI: 28.23–77.20). Additionally, the moderate mental health class was linked to low family income (OR: 1.88; 95% CI: 1.30–2.72), living with family (OR: 0.70; 95% CI: 0.49–0.99), and failed academic achievement (OR: 1.50; 95% CI: 1.06–2.11). However, no significant associations were found for middle family income (OR: 1.27; 95% CI: 0.93–1.74) and dwelling in university residence (OR: 0.81; 95% CI: 0.60–1.10) as predictors.Conclusion: This study revealed that a considerable number of university students aged 18 to 24 were vulnerable to mental health issues, irrespective of gender and age. However, students belonging to classes with low incomes and those who did not pass exams were identified as the most vulnerable groups. It is crucial to pay particular attention to these students and provide appropriate support and interventions.
Retrospective Analysis of Hematological Abnormalities in Older Diabetic Patients with SARS-CoV-2 Infection
Authors: Rawi Omar , Zidan Miaaz , Al Naama Abdullah
Published: December 2023

Background: Understanding the severity of Coronavirus Disease 2019 (COVID-19) in elderly diabetic patients is crucial, considering the impact of age, comorbidities, and clinical biomarkers. However, the assessment of common haematological markers in this specific population remains limited.
Methods: We conducted a retrospective cohort study involving 27 elderly patients (mean age: 61.81±7.14 years) with COVID-19 infection. We analysed the medical e-records of COVID-19 positive patients who presented to a COVID-19 centre in Qatar in July 2020. Real-Time Polymerase Chain Reaction was used to confirm COVID-19 infection using throat-swab upper respiratory samples. Clinical haematological parameters were analysed and compared with normal ranges.
Results: Among the 27 patients investigated, 51.85% were male. A low viral load (cycle threshold (Ct) ≥ 30) was observed in 7.4% of patients, while 92.59% had a high viral load (Ct < 30). At presentation, 59.25% of patients were symptomatic. The observed haematological abnormalities ranked in descending order of frequency were as follows: high red blood cell counts, and high mean platelet volume (52% each), high platelet distribution width (48%), low haemoglobin values, and low haematocrit values (22% each), leukopenia, neutropenia, and lymphopenia (15% each), thrombocytosis, thrombocytopenia, leucocytosis, and neutrophilia (7% each), and lymphocytosis (4%).
Conclusion: Our study highlights the common occurrence of haematological abnormalities in older diabetic patients with COVID-19 infection. Monitoring haematological parameters may be valuable in managing these patients, especially in severe cases, and could facilitate early identification of individuals requiring intensive care, potentially reducing mortality.
Keywords: Geriatric Medicine; Public Health; Real-Time Polymerase Chain Reaction; Risk Factor; SARS-CoV-2; Symptomatic Infection; Thrombocytopenia; Viral Load
Selçuklu İslâm Hukuku Yükseliş Devri (1063-1092) (Ömer Menekşe, İstanbul: Bilge Yayıncılık, 2022, 224 sayfa) ( ISBN:978-625-7201-47-6)
Authors: GÜMÜŞ BÖKE Emine
Published: December 2023

Ömer Menekşe’nin ele aldığı “Selçuklu İslâm Hukuku Yükseliş Devri” çalışması genelde hukuk tarihi özelde ise İslâm Hukuk Tarihine dair bir araştırmadır. Eser, Selçukluların ilim ve kültür hayatı bakımından en parlak dönemi olan Yükseliş Devrini incelenmesi bakımından İslâm hukuk tarihi alanına katkı sağlayan bir çalışmadır. Türk-İslâm tarihinde önemli bir yeri olan Selçuklu Devleti’nin hukuk ilmine yönelik hizmetleri hem sosyal hem siyasal alanlarda etkisini göstermiş ve bu dönem ilmî faaliyetler hususunda birçok gelişmeye sahne olmuştur. Bu çalışmada müellif Selçukluların ilmi açıdan zirve çağını yaşadığı Yükseliş devrindeki İslâm hukuk anlayışını ele almıştır.
Study of Incompressible Jets from Various Orifices
Authors: Sarma M.S. , Sundararajan T. , Ramjee V.
Published: December 2023

The experiments were done in incompressible jets using different orifices namely circle, ellipse, rectangle, triangle and six lobed. Numerical predictions using FLUENT code are compared with the experimental data and they seem to agree well. The spreading rate is lower for the circular orifice and highest for the triangular orifice. The Reynolds shear stress an- turbulent kinetic energy are predicted for all the jets up to 16 equivalent diameters.
Stage Separation System Design and Dynamic Analysis of Isro Launch Vehicles
Authors: Jeyakumar D. , Biswas K.K.
Published: December 2023

Stage separation system design and dynamic analysis is an integral part of the design and development of any multistage launch vehicles. Lower stage separation especially, strapon separation qttracts specific attention if the separation occurs in the dense atmospheric region as aerodynamics plays a major role in design of separation system. FLSC is used to seyere the stages and spring thrusters or side rockets are used to provide required jettisoning velocity depending on the stage inert mass. In the booster stage separation, FLSC based severing together with retro-rockets or VIS separation systems are used to provide separation velocity. In VIS the continuing stage jet impingement force is used to provide required jettisoning velocity for the spent body. In heat shield separation, the impulse generated by Zip cord mechanism excites the rigid body and flexible modes of the heat shield. By superimposing flexible response over the rigid body motion dynamic analysis were carried out. The upper stages and spacecraft separation systims use clamp band joints with pyro assisted release mechanisms together with spring thrusters as jettisoning devices. Spring thrusters were used for spacecraft separation due to the requirement of low shock level and contamination free environment. In this paper, an attempt is made to expLain the experiences gained over the design, development, 6-D dynamic simulation studies and the improvements carried out for the four-generation Indian Launch Vehicles development programme namely SLV, ASLV, PSLV and GSLV in the last two decades.
Mode of Psychosomatic Medical Integration: Exploring the Pathogenesis of Heart, Brain-body Interaction
Authors: Yang Meng , Bi Yanfang , Yang Hongmei
Published: December 2023

At present, the methods of neuroscience research have been widely used in the field of psychosomatic medical research, and now the mainstream medicine has developed a strong interest in integration, which is also a necessary prerequisite for the greater development of psychosomatic medicine. Explore multidisciplinary, multimodal, the integration of medical treatment, is expected to make patients with psychosomatic disorder treatment effect of progress, so that the causal mechanism of psychosomatic disease in new areas, compared with previous physical and mental medical research, now the neuroscience research results have stronger credibility, nerve medical research will be more psychosomatic medical research mode brings new inspiration, bring new ideas to psychosomatic disease diagnosis and treatment. Based on this, the paper proposed the integration model of mind and physical medicine, and respectively discussed the mechanism of mental and body interaction, body and body interaction, multiple and multiple interaction between mind and body, hoping to provide reference for related work.
The Impact of Corporate Digital Transformation on Green Technological Innovation in the Context of "Dual-Carbon" Goals
Authors: Gan Yufei , Sun Ting , Chen Yican , Wu Tian , Liu Yuhan , Wang Siyu , Den Zichen , Zhang Junlin
Published: December 2023

Driven by global "dual-carbon" objectives, the relationship between corporate digital transformation and green technological innovation is receiving increasing attention. Drawing on panel data from Chinese A-share listed companies from 2015-2021, this study empirically examines the impact of digital transformation on corporate green innovation, as well as the moderating role of ESG (Environmental, Social, and Governance) performance. The results indicate that digital transformation significantly promotes green innovation. Furthermore, companies with better ESG performance demonstrate a stronger promotion of green innovation through digital transformation. To confirm the robustness of our findings, the Bootstrap method and robust standard errors were employed. Subsequent heterogeneity analysis revealed that the ESG effect is more pronounced in state-owned enterprises, and the marginal effects of digital transformation diminish over time. This research not only enriches the micro-mechanism studies on digital transformation and green development but also offers insights for managerial practice and policy formulation.
Pengaruh citra merk dan celebrity endorsment terhadap keputusan pembelian produk skincare wardah pada generasi z (studi kasus di kota denpasar)
Authors: Enayanti Ni Made , Sukanti Ni Ketut
Published: December 2023

This study aims to determine the effect of brand image and celebrity endorser on purchasing decisions for Wardah skincare products in Denpasar City. This study uses a quantitative approach. The data used are skincare review viewer data and local brand sales data in e-commerce in 2021, the sample testing technique is carried out through a sampling method that uses classical assumption testing, determination analysis, linear multiple analysis, partial (t-test) and simultaneous testing. (f-test). The results of this study prove that brand image has a positive and significant effect on purchasing decisions, celebrity endorsers have a positive and significant effect on purchasing decisions. Simultaneously brand image and celebrity endorser have a significant effect on purchasing decisions.
Migrants vénézuéliens en Équateur : confronter la criminalisation symbolique par l’espace
Authors: Vargas Aguirre Martha , Yapud Ibadango Guadalupe
Published: December 2023

En 2018, le gouvernement équatorien a fait face à un afflux massif de Vénézuéliens fuyant la crise humanitaire et politique dans leur pays. Dans cet article, nous examinons la politique migratoire déployée entre 2018 et 2019 par le gouvernement équatorien pour réguler ces arrivées. Pour ce faire, nous développons une articulation théorico-analytique restreinte ; nous mobilisons la perspective foucaldienne des études critiques des politiques publiques (Foucauldian Critical Policy Studies), à travers l’utilisation du concept foucaldien de problématisation et nous l’articulons à la production sociale de l’espace dans le cadre de la géographie critique. Ainsi, grâce à l’analyse des documents de politique publique, nous concluons que le gouvernement équatorien criminalise symboliquement la population vénézuélienne en la problématisant comme dangereuse et potentiellement criminelle. En revanche, les entretiens avec les immigrés vénézuéliens montrent que la population migrante répond et résiste à cette problématisation par le biais de stratégies sociospatiales. De cette manière, cette analyse cherche à contribuer aux rares études sur la criminologie de la mobilité dans le Sud global.
pedagogia freireana
Authors: Fortuna Volnei
Published: December 2023

O artigo tem como tema A pedagogia freireana: um diálogo sobre a liberdade, enunciando a influência do pensamento freireano na superação da opressão em vistas da humanização. O problema da pesquisa compreende qual a importância e atualidade da pedagogia freireana na consolidação de sociedades humanizadas? O objetivo consiste em analisar de forma reflexiva a pedagogia freireana, sua importância e atualidade em provocar no ser humano a capacidade de superação da opressão por meio da formação de consciência crítica e humanizadora. Para a problematização do estudo, segue-se o método hermenêutico-dialético, atentando-se de forma analítica e reflexiva ao referencial teórico freireano. Nesse contexto, a historicidade é ponto primordial para a dinâmica formativa da consciência de si e de outrem. Ter consciência do ser e estar no mundo com os outros, das fragilidades existentes na sociedade, abrem-nos caminhos de práxis, de criação e recriação de uma formação genuína, capaz de tornar o mundo mais bonito. Destaca-se que o espaço educacional é um berçário de grandes causas, e a teoria e o método freireano corroboram com o diálogo problematizador e coloca o sujeito numa condição de intervenção e transformação das realidades. Em síntese, encontra-se na pedagogia freireana elementos epistemológicos que colocam o diálogo como potência geradora de solidariedade, de humanização e de garantia da dignidade humana. A história do sujeito se faz e se refaz no exercício de relações humanas saudáveis, pautadas pela diversidade existe nas sociedades.
Abordagem integrativa em cão com doença articular degenerativa - Relato de caso
Authors: Gonçalves Giovanna Zokner , Mariani Luiza Prado Ricardo dos Santos , Capriglione Luiz Guilherme Achcar , Michelotto Junior Pedro Vicente
Published: December 2023

A osteoartrite (OA) ou doença articular degenerativa (DAD) é uma das causas da redução da mobilidade e claudicação frequentemente observada na clínica de animais de companhia, provocando dor miofascial e podendo levar à paralisia de membros, dependendo da evolução da patologia. O diagnóstico é feito através dos sinais clínicos, exames ortopédicos, neurológicos e imagiológicos como radiografia. O tratamento pode ser feito com base em anti-inflamatórios, nos casos de dor crônica, medicamentos como tramadol e gabapentina e/ou cirurgia. A analgesia também pode ser obtida com laserterapia, termoterapia e acupuntura. A medicina integrativa é um conjunto de terapias com o objetivo de proporcionar melhora no quadro clínico dos pacientes e cura de patologias; entre elas estão a Medicina Tradicional Chinesa (MTC), medicina japonesa, aromaterapia, cromoterapia e ozonioterapia. O objetivo deste trabalho é demonstrar que o conjunto de terapias utilizado foi eficaz para a redução da dor miofascial e promoção da qualidade de vida de uma cadela geriátrica, acometida por uma doença crônica. Neste trabalho, estas terapias foram utilizadas durante o tratamento de uma cadela, de 14 anos, acometida por DAD avançada, com tetraparesia, alta dor miofascial e contratura muscular, além de outros sinais como alteração no ciclo do sono e emocional, polidipsia, tosse, lesões cutâneas em face e vocalização devido à dor. O diagnóstico da MTC foi obtido por anamnese, teste neurológico e palpação, além de inspeção de língua. Diagnosticou-se disfunções de Qi, Xue, Yin e Yang de rim, fígado, baço, pulmão e estômago. Ao total foram 15 sessões. As terapias utilizadas foram aromaterapia, Gua Sha, moxabustão cromoterapia, ozonioterapia, Tuiná, craniopuntura (YNSA) e acupuntura. No início das sessões a paciente encontrava-se com rigidez articular e muscular; com o passar das sessões, obteve maior flexibilidade dos membros, regularizou o sono e o temperamento, reduziu a sede intensa e tosse, interagia mais com o ambiente e passou a ter mais força muscular. De todas as terapias, as que obtiveram melhor resultado foram as que utilizaram fonte de calor, pressão na musculatura com massagens e/ou pressão rítmica e o agulhamento.
Transtorno do Déficit de Atenção e Hiperatividade (TDAH) em adultos:
Authors: Cordeiro de Souza Assef Neto Rosangela , Abdala Lins Rosane , Soares Guimarães Maria Cristina
Published: December 2023

Caracterizado por um padrão persistente de desatenção, hiperatividade e impulsividade o Transtorno do Déficit de Atenção e Hiperatividade (TDAH) afeta cerca de 5 a 8% das crianças em todo o mundo e prevalece até a idade adulta. É considerado um dos transtornos mentais mais comuns segundo a Organização Mundial de Saúde. Buscou-se com esse trabalho traçar um panorama da publicação científica brasileira sobre o TDAH em adultos, para tal foi realizada uma busca na plataforma Scopus. Os dados recuperados mostram que a publicação científica sobre o tema no mundo tem crescido ao longo dos anos e a posição do Brasil no ranking mundial está em 11º lugar, com a publicação brasileira tendo uma projeção internacional em crescimento. Além dos dados de publicação, o Brasil tem grupos de pesquisa ativos no tema com uma forte rede relacionamento entre os autores.
Research on the control strategies of data flow transmission paths for MPTCP-based communication networks
Authors: Shu Zhong , Du Hua-Bing , Zhu Xin-Yu , Ruan Shi-Xin , Li Xian-Ran
Published: December 2023

The performance of multipath transmission control protocol (MPTCP) subflow through the enhancement mechanism of the MPTCP communication is improved. When dealing with multiple MPTCP subflows occupying the same transmission path, critical issues such as selection and optimization of multipath, and efficient scheduling of available multiple tracks are effectively addressed by incorporating the technology called software defined network (SDN) that is constructed based on four key parameters, namely, network transmission bandwidth, transmission paths, path capacity, and network latency. Besides, critical equipment such as the network physical device layer and SDN controller are integrated with the four parameters. So, the network model defines the transmission control process and data information. Considering the predetermined total network bandwidth capacity to select multiple paths, the adequate bandwidth capacity is determined by defining the data transfer rate between MPTCP terminals and MPTCP servers. However, the processing latency of the OpenFlow switch and the SDN controller is excluded. The effective network transmission paths are calculated through two rounds of path selection algorithms. Moreover, according to the demand capacity of the data transmission and the supply capacity of the required occupied network resource, a supply and demand strategy is formulated by considering the bandwidth capacity of the total network and invalid network latency factors. Then, the available network transmission path from the valid network transmission path is calculated. The shortest path calculation problem, which is the calculation and sorting of the shortest path, is transformed into a clustering, Inter-Cluster Average Classification (ICA), problem. The instruction of the OpenFlow communication flow is designed to schedule MPTCP subflows. Thus, various validation objectives, including the network model, effective network latency, effective transmission paths, supply-demand strategies, ineffective transmission paths, shortest feasible paths, and communication rules are addressed by the proposed method whose reliability, stability, and data transmission performance are validated through comparative analysis with other conventional algorithms. Found that the network latency is around 20 s, the network transmission rate is approximately 10 Mbps, the network bandwidth capacity reaches around 25Mbps, the network resource utilization rate is about 75%, and the network swallowing volume is approximately 3 M/s.
Um estudo bibliométrico dos métodos de valuation na transferência de tecnologia de patentes e outros ativos intangíveis
Authors: Sabino Hugu Soares , Silva Felipe Eduardo de Oliveira , Queiroz Lísia de Melo
Published: December 2023

A valoração refere-se à tarefa de determinar o valor monetário tanto individual quanto em conjunto de um ativo no momento de sua transferência. O objetivo do trabalho é analisar as produções científicas na área de valoração de transferência de tecnologia por meio de um estudo bibliométrico, buscando delimitar quais os métodos mais utilizados em produções científicas integradas entre os níveis Qualis A1-B2. A contribuição do estudo perpassa pela construção de uma análise minuciosa do emprego dos métodos de valuation na transferência de ativos intangíveis, denotando resultados que contribuem para a academia e organizações por se tratar de um grupo de ativos que representam benefícios futuros e vantagem competitiva organizacional. Os resultados mostram que o método de valoração mais utilizado é o Fluxo de Caixa Descontado, demarcando, dessa maneira, uma lacuna de pesquisa a ser explorada na academia por meio da adoção dos demais métodos de valoração de Transferência de Tecnologia.
The First Cases of Sudden Sensorineural Hearing Loss Post Coronavirus Disease in Children
Authors: Chrysouli Konstantina , Savva Ioannis Pavlos , Karamagkiolas Sotirios
Published: December 2023

To investigate the incidence, characteristics, diagnosis, treatment, and prognosis of coronavirus disease (COVID-19)-related sudden sensorineural hearing loss (SSNHL) in children, three cases of SSNHL after COVID-19 infection in children were analyzed. ENT clinical examination of all cases was normal. Only the third child had a first degree left-beating optokinetic nystagmus, compatible with right peripheral vestibulopathy. The audiogram indicated unilateral severe SSNHL in all frequencies. Computed tomography and magnetic resonance imaging of the brain and temporal bones also showed absence of pathology of the related structures. Oral methylprednisolone was administered to the first two cases, whereas intravenous methylprednisolone in a tapering form was administered to the third case. Additionally, the children underwent intratympanic dexamethasone injections and hyperbaric oxygen therapy with hearing improvement in lower and middle frequencies. The prognosis of COVID-19-related SSNHL in children is closely related to the onset of treatment. The combination of glucocorticoids, intratympanic dexamethasone injections, and hyperbaric oxygen therapy could be effective for COVID- 19-related SSNHL in children. Further large-scale, multicenter studies should be conducted to investigate the pathophysiology, diagnosis, treatment, and prognosis of COVID- 19-related SSNHL.
Efficacy and Safety of the Heat Shock Protein 90 Inhibitor RGRN-305 in Hidradenitis Suppurativa
Authors: Ben Abdallah Hakim , Bregnhøj Anne , Emmanuel Thomas , Ghatnekar Gautam , Johansen Claus , Iversen Lars
Published: December 2023

Importance

Hidradenitis suppurativa is a painful immune-mediated disorder with limited treatment options; hence, a need exists for new treatments.

Objective

To evaluate the feasibility of heat shock protein 90 inhibition by RGRN-305 as a novel mechanism of action in treating moderate to severe hidradenitis suppurativa.

Design, Setting, and Participants

This was a parallel-design, double-blind, proof-of-concept, placebo-controlled randomized clinical trial conducted between September 22, 2021, and August 29, 2022, at the Department of Dermatology, Aarhus University Hospital in Denmark. The study included a 1- to 30-day screening period, a 16-week treatment period, and a 4-week follow-up period. Eligibility criteria included age 18 years or older and moderate to severe hidradenitis suppurativa with 6 or more inflammatory nodules or abscesses in at least 2 distinct anatomic regions. Of 19 patients screened, 15 patients were enrolled in the study. Intention-to-treat analysis was performed.

Interventions

Patients were randomly assigned (2:1) to receive oral RGRN-305, 250-mg tablet, or matching placebo once daily for 16 weeks.

Main Outcomes and Measures

The primary efficacy end point was the percentage of patients achieving Hidradenitis Suppurativa Clinical Response 50 (HiSCR-50) at week 16. Secondary efficacy end points included HiSCR-75 or HiSCR-90, Hidradenitis Suppurativa Physician’s Global Assessment, Dermatology Life Quality Index scores, and a pain numeric rating scale. Safety was assessed by adverse events, physical examinations, clinical laboratory measurements, and electrocardiograms.

Results

A total of 15 patients were enrolled, completed the study, and were included in all analyses (10 [67%] female; median age, 29 [IQR, 23-41] years). The primary end point HiSCR-50 at week 16 was achieved by a higher percentage in the RGRN-305 group (60% [6 of 10]) than in the placebo group (20% [1 of 5]). Improvements were also observed across all secondary end points at week 16, including higher rates of the harder-to-reach HiSCR levels; 50% (5 of 10) achieved HiSCR-75 and 30% (3 of 10) achieved HiSCR-90, whereas none of the placebo-treated patients achieved HiSCR-75 or HiSCR-90. RGRN-305 was well tolerated, with no deaths or serious adverse events, and treatment-emergent adverse events were similarly frequent between the RGRN-305 and placebo groups.

Conclusions and Relevance

The findings of this trial suggest that heat shock protein 90 inhibition by RGRN-305 offers a novel mechanism of action in treating hidradenitis suppurativa, warranting further evaluation in larger trials.

Trial Registration

ClinicalTrials.gov Identifier: NCT05286567
An Integrated Asymmetric Wet Adhesive Hydrogel with Gradient Charge Distribution Induced by Electrostatic Field
Authors: Xu Zhicheng , Liang Xuejiao , Ma Wencan , An Xiaoming , Wu Haomin , Zhang Qiuhong , Jia Xudong
Published: December 2023

Adhesive hydrogels have been applied in biomedical field as an alternative to surgical sutures. However, there still exist rigorous challenges in rough underwater adhesion and asymmetric adhesion of hydrogels, especially applied in wound healing and organ repair in vivo. Herein, a strategy is proposed to prepare integrated hydrogels with asymmetric underwater adhesion capability by forming the asymmetric electrical interface under an electrostatic field. The synergistic effects between catechol and amine and complex coacervation are used to improve the underwater adhesion of hydrogel. Furthermore, by applying an electrostatic field, the cations and anions in solution of monomers are separated to form asymmetric adhesion interfaces. The hydrogel exhibits obvious asymmetric underwater adhesion ability on porcine skin with a strong adhesive strength of 97 kPa on cation side and 25 kPa on the anion side. Animal experiment outcomes reveal that only one side of the asymmetric hydrogel could adhere firmly to the rat liver and the rabbit stomach, while the other side could not effectively prevent postoperative tissue adhesion. The asymmetric distribution of adhesive molecules induced by electrostatic fields will provide a new alternative for designing and adjusting asymmetric adhesives after surgery.
Orthogonal Three‐Wavelength‐Controlled Two‐Stage Supramolecular Self‐Assemblies
Authors: Zhu Fengfan , Chen Xu‐Man , Ge Yang , Li Mengyao , Li Naixu , Zhou Jiancheng , Chen Wenshuai
Published: December 2023

Photoswitchable supramolecular self‐assemblies are promising candidates for intelligent recognition because of their noninvasive and spatial precision. However, the manipulation of the self‐assembly and disintegration of multicomponent mixtures with light of different wavelengths remain difficult. Here, an orthogonal three‐wavelength‐controlled two‐stage supramolecular self‐assembly consisting of two photoswitches, diarylethene, and protonated merocyanine is designed, mediated by supramolecular macrocyclic host. Owing to the reversible photo‐transformation of the switches, an optimized approach including three wavelengths irradiation and a thermal relaxation process is developed without mutual interference, realizing interconversion among four self‐assembled states. These self‐assemblies are photodeformable with reversibility, which can be operated in a cellular environment. Taking advantage of the photochromism in both absorption and fluorescence of these self‐assemblies in different behaviors, a visual pattern that can simultaneously display multiple hidden information under dual‐signal emission is created. This work signifies a promising strategy in improving the ability of information encryption and anti‐counterfeiting.
Improving the Stability of Halide Perovskites for Photo‐, Electro‐, Photoelectro‐Chemical Applications
Authors: Du Fenqi , Liu Xiaolong , Liao Jinfeng , Yu Dejian , Zhang Nan , Chen Yiwang , Liang Chao , Yang Shengchun , Fang Guojia
Published: December 2023

Owing to their remarkable and adjustable optoelectronic properties, halide perovskites (HPs) have been regarded as a class of promising materials for various optoelectronic applications based on different energy conversion reactions, including photovoltaic cell, photocatalysis, electrocatalysis, and photoelectrochemical (PEC) systems. However, the low stability of HPs upon exposure to ambient conditions (e.g., water, heat, light, electricity) greatly hinders the practical applications of HPs. In the past few years, significant efforts have been devoted to enhancing the eventual stability of the perovskite‐based optoelectronic systems, mainly focusing on delivering improvements in the stabilities of halide perovskite materials and the relevant operation conditions of optoelectronic systems, which deserve in‐depth and systematic summaries. In this comprehensive review, the in‐depth environment‐induced decomposition mechanisms of typical HPs are elucidated. Simultaneously, the strategies for addressing the instability issues of halide perovskite materials are critically reviewed, including dimension control, compositional engineering, ligand passivation, and encapsulation engineering. Furthermore, the photoelectric applications based on the modified HPs and operation conditions are discussed systematically. In the last part of this review, future perspectives and outlooks toward the stability of HPs and their photoelectric applications are envisaged respectively.
Interfacial Engineering of Cobalt Thiophosphate with Strain Effect and Modulated Electron Structure for Boosting Electrocatalytic Hydrogen Evolution Reaction
Authors: Song Kai , Zhang Huanhuan , Lin Zhiping , Wang Zongpeng , Zhang Lili , Shi Xinxing , Shen Shijie , Chen Shichang , Zhong Wenwu
Published: December 2023

The fabrication of heterojunctions is an intriguing approach to boost the reactivity of catalysts. However, facile preparation of desirable heterojunction materials remains a challenge. Here, novel CoPS3/CoS2 heterojunctions are created by an intuitive phosphatization process on the basis of structurally flexible cobalt sulfide precursors. Significant stress effect exists at these heterogeneous interfaces, resulting in lattice distortions and the exposure of more active sites. The interface interaction also modifies the catalyst's electronic structure to improve its electrical conductivity and hydrogen adsorption capabilities. Notably, the overpotential of the CoPS3/CoS2 heterojunction for electrocatalytic hydrogen evolution reaction is just 36.3 mV, which is far superior to those of single‐component catalysts and competitive with comparable catalysts reported. This work not only offers an innovative electrocatalyst but also a strategy that can be used to create heterojunctions based on related transition metal thiophosphates.
Durable Radiative Cooling Multilayer Silk Textile with Excellent Comprehensive Performance
Authors: Wu Xun‐En , Wang Yida , Liang Xiaoping , Zhang Yong , Bi Peng , Zhang Mingchao , Li Shuo , Liang Huarun , Wang Shuai , Wang Haomin , Lu Haojie , Zhang Yingying
Published: December 2023

Passive radiative cooling without energy consumption is increasingly being explored as an eco‐friendly alternative to electric cooling for mitigating heat stress caused by global warming. Incorporating radiative cooling into personal thermal management has garnered widespread interest. However, existing sub‐ambient radiative cooling textiles face challenges related to inferior solar reflectance, poor outdoor durability, or health concerns. Here, a durable multilayer silk textile (MST) is developed that achieves excellent comprehensive performance for the first time, including both ultrahigh solar reflectance (96.5%) and ultrahigh infrared emittance (97.1%), safety, air and moisture permeability, high mechanical strength, washability, abrasion resistance, surface hydrophobicity, and UV resistance. The MST achieves a remarkable sub‐ambient temperature drop of 5.1 °C under 892.4 W m−2 of ultra‐strong solar radiation and surpasses both commercial silk and cotton textiles at noon with temperature reductions of 6.0 and 8.3 °C, respectively. For proof of concept, a hat using the MST is fabricated, which shows improved cooling performance compared to commercial hats. Considering its outstanding cooling performance, durability, zero energy consumption, abundant raw materials, and scalable production ability, it is believed that the radiative cooling MST holds great promise for practical applications in daytime personal thermal management.
On‐Surface Ullmann‐Type Coupling: Reaction Intermediates and Organometallic Polymer Growth
Authors: Houtsma R.S. Koen , van Zuilen Jeanne , Stöhr Meike
Published: December 2023

Ullmann‐type coupling is the most widely used on‐surface reaction to form rationally designed bottom‐up molecular nanoarchitectures. A commonly observed reaction product in this reaction is an organometallic phase, however little is known about the formation of this phase. The on‐surface polymerization of the prochiral precursor 6,12‐dibromochrysene (DBCh) on Ag(111) is studied. Upon annealing of DBCh on Ag(111), a linear organometallic polymer forms. However, the delicate energy balance involved in the polymerization of DBCh is such that, at room temperature, several reaction intermediates, which eventually lead to the formation of the organometallic polymer, can be observed experimentally. Organometallic monomers, dimers, and trimers are finds, that self‐assemble into distinct networks. The experimental availability of these reaction intermediates provides key insights into the formation of the organometallic polymer. Comparing the chirality of the intermediates and the polymer sheds additional light on the reaction mechanism leading to the formation of the polymer. The main finding is that the organometallic polymer is not formed by a simple coupling of the reaction intermediates, but rather requires the breaking and re‐establishing of the C─Ag bonds. Additionally, a Br‐enhanced growth mode is observed, where the split‐off halogens align the polymers, which results in an increased polymer length.
Encapsulation of Disodium‐EDTA in Electrospun Polymeric Fibers for the Detection of Heavy Metals
Authors: Fotia Antonio , Frontera Patrizia , Bonaccorsi Lucio , Sciacca Beniamino , Malara Angela
Published: December 2023

The contamination by heavy metals (HMs) is a pressing issue, due to their serious impact on the environment and human health. Therefore, the design and the development of a sensing material for their detection has gained a lot of attention. In this study, active layers are produced by the electrospinning technique, using three different polymers and disodium salt of ethylenediaminetetraacetic acid (Na2‐EDTA), known to be a chelating substance for heavy metals. The optimized active layer, in terms of polymer type, degree of encapsulation of the salt, as well as salt suitable content, is obtained and tested using the electrochemical impedance spectroscopy technique. The results of the sensing tests indicate the suitability of the developed electrospun layer for environmental monitoring. It is shown the detection of lead in the range of 10–100 000 µg L−1, with a detection limit of 0.031 µg L−1. Moreover, the system is proved to be robust against interfering contaminants such as thallium, another relevant heavy metal.
Theoretical study of blue‐green iridium(III) complexes with low‐efficiency roll‐off properties for application in phosphorescent organic light‐emitting diodes
Authors: Chi Hao‐Yuan , Ji Ye , Zhang Yun‐Kai , Zhao Xue‐Ming , Qu Shao‐Jun , Jiang Fang‐Da , Lu Chang‐Hai , Xiao Bo , Song Ming‐Xing , Li Dong‐Fei
Published: December 2023

To find an array of suitable materials for phosphorescent organic light‐emitting diodes (OLEDs), in this paper, we design six blue‐green phosphorescent Ir (III) complexes that have low‐efficiency roll‐off properties. Density functional theory and time‐dependent density functional theory were used to study the properties of (2‐[4‐phenoxyphenyl]pyridine [oppy])2Ir(acetylacetonate [acac]), (oppy)2Ir(picolinate [pic]), (oppy)2Ir(tetraphenylimido‐diphosphinate [tpip]), (5‐fluoro‐2‐(4‐phenoxyphenyl)pyridine [F‐oppy])2Ir(acac), (F‐oppy)2Ir(pic), and (F‐oppy)2Ir(tpip). Here, the main ligands are oppy and F‐oppy, while the auxiliary ligands are acac, pic, and tpip. The advantages of these complexes were analyzed in terms of electronic structure, frontier molecular orbital properties, spectral properties, and OLED display effect. We hope that our research will contribute to the development of the OLED industry.
Synthesis and biological evaluation of (2‐aminosulfonylpyridin‐6‐yl)pyrazolopyrimidinone derivatives as Wee1 inhibitors for cancer treatment
Authors: Kim Yeon Ju , Jung Myoung Eun , Lee Ju Yeong , Lee Yun‐Han , Choi Gildon , Jeon Moon‐Kook
Published: December 2023

For an analog‐based design of novel Wee1 inhibitors, we profiled in vitro ADMET and in vivo PK properties of adavosertib. Based on the properties of adavosertib, we aimed to improve its metabolic stability by designing a novel target compound 1a with an aminosulfonyl group instead of the 2‐hydroxypropan‐2‐yl moiety in adavosertib. Derivatives of target compound 1a were synthesized and evaluated for Wee1 enzyme inhibition and liver microsomal phase I stability. We identified compound 1a as a sub‐nanomolar Wee1 inhibitor and 10 additional compounds with one‐digit nanomolar Wee1 inhibitory activity, among which seven compounds including 1a exhibited improved metabolic stabilities compared with adavosertib. However, MDA‐MB‐231 cell growth inhibitory activities of all synthesized compounds and Wee1 substrate phosphorylation inhibitory activities of selected compounds were inferior to adavosertib overall. Moreover, the representative compound 1a exhibited low permeability, which may be the reason for the low cellular activities of compound 1a.
Cues associated with a single ethanol exposure elicit conditioned corticosterone responses in adolescent male but not female Sprague–Dawley rats
Authors: Gano Anny , Barney Thaddeus M. , Vore Andrew S. , Mondello Jamie E. , Varlinskaya Elena I. , Pautassi Ricardo M. , Deak Terrence
Published: December 2023

It has been shown that ethanol‐induced interleukin‐6 (IL‐6) in adult male Sprague–Dawley rats was sensitized by environmental stimuli paired with ethanol and was accompanied by a conditioned increase in corticosterone (CORT). Adolescent males showed ethanol‐induced IL‐6 conditioning more readily than adults. The present studies examined whether female adolescents display IL‐6 conditioning and whether adolescents of either sex show CORT conditioning. Male and female (N = 212, n = 6–10) adolescent (postnatal day 33–40) rats were given ethanol (2 g/kg intraperitoneal injection; the unconditioned stimulus), either paired with a lavender‐scented novel context (the conditioned stimulus) or explicitly unpaired from context. Rats were tested in the context without ethanol and brains/blood were collected. Adolescent females did not show signs of neuroimmune (Experiment 1) or CORT conditioning (Experiments 2–4). Paired males showed enhanced CORT to the scented context relative to unpaired counterparts when the interoceptive cue of a saline injection was used on test day (Experiment 2). Experiment 5 used a delayed conditioning procedure and showed that male paired adolescents showed significantly higher CORT in response to context, showing that classically conditioned CORT response was precipitated by environmental cues alone. These findings indicate that adolescent males may be predisposed to form conditioned associations between alcohol and environmental cues, contributing to adolescent vulnerability to long‐lasting ethanol effects.
Maternal psychological risk and the neural correlates of infant face processing: A latent profile analysis
Authors: Wall Kathryn M. , Penner Francesca , Dell Jaclyn , Lowell Amanda , Potenza Marc N. , Mayes Linda C. , Rutherford Helena J. V.
Published: December 2023

Maternal psychological factors, including anxiety, depression, and substance use, may negatively affect parenting. Previous works with mothers have often assessed each of these factors in isolation despite their frequent co‐occurrence. Psychological factors have also been associated with neural processing of facial stimuli, specifically the amplitude (i.e., size) and latency (i.e., timing) of the face‐specific N170 event‐related potential. In the current study, 106 mothers completed measures assessing maternal psychological factors—anxiety, depression, and substance use. A latent profile analysis was used to identify profiles of psychological factors and assess profile associations with the N170 elicited by infant faces and with parental reflective functioning (PRF) as a measure related to caregiving. Two profiles (termed high and low psychological risk) were identified, with the higher risk profile associated with delayed N170 latency responses to infant faces. An exploratory analysis evidenced an indirect effect between the higher psychological risk profile and lower PRF through delayed N170 latency responses to infant faces. Taken together, maternal psychological risk across multiple indicators may together shape neural processing of infant faces, which may have downstream consequences for caregiving.
Fast sequential determination of amoxicillin and clavulanate in pharmaceutical samples using batch injection analysis with amperometric detection
Authors: Boane Anastácio A. , De Faria Lucas V. , Ramos David R. , Marra Mariana C. , Sousa Raquel M. F. , Muñoz Rodrigo A. A. , Richter Eduardo M.
Published: December 2023

The combination of amoxicillin (AMX) and clavulanic acid (CLA) is one of the most widely used antibiotic medicines in the world. This paper describes a novel electrochemical method for the fast sequential determination of AMX and CLA using batch injection analysis with amperometric detection (BIA‐AD) and boron‐doped diamond (BDD) as the working electrode. In the proposed strategy, AMX was selectively detected at +1.3 V and both compounds (AMX+CLA) at +1.8 V. The oxidation current from CLA was accessed by subtracting the currents detected at both potential pulses (i+1.8 V–i+1.3V) and using a simple correction factor. The developed method proved to be simple, cost‐effective, precise (RSD<1.3 %, n=10), rapid (>200 injection h−1), required simple sample preparation steps (dissolution and dilution only) and can be used in laboratories with minimal infrastructure (portable characteristics). The limits of detection were 0.31 (0.13) and 1.99 (0.47) μmol L−1 (mg L−1) for AMX and CLA, respectively. The results obtained by the proposed BIA‐AD method were comparable to those obtained by capillary electrophorese (95 % confidence level).
Research on the optimal model for the evaluation of new power system investment projects based on the cloud model–DS evidence theory–TOPSIS method
Authors: Ma Shun , Chen Ming , Mei Shiyan
Published: December 2023

Considering that the traditional investment project evaluation system can no longer fully adapt to the characteristics of the new power system under the investment environment of the new power system, this study constructed a new power system investment project evaluation and optimization method based on the combination of the cloud model, evidence theory and the TOPSIS method. First, 16 evaluation indexes were considered based on four dimensions, namely green and low‐carbon, safe and reliable, flexible and intelligent, and economical and efficient, and the optimal evaluation index system of new power system investment projects was designed. Second, the normal cloud model was used to obtain the evaluation membership distribution of each index and turn it into evidence. Considering the conflicts between indicators and the combinational contradictions of traditional evidence theories, an improved DS evidence theory based on a game weight coefficient discount to reduce conflicting evidence was used to fuse the membership information of multiple indicators. On the basis of the evaluation results of each scheme, this study used the TOPSIS method to sort the advantages and disadvantages of each scheme. Finally, the project of planning and putting this model into operation in the 14th Five‐Year project database of a power grid enterprise was selected as an example to carry out empirical analysis, and the effectiveness and superiority of the proposed model were verified.
Forecasting CPI with multisource data: The value of media and internet information
Authors: Zheng Tingguo , Fan Xinyue , Jin Wei , Fang Kuangnan
Published: December 2023

Using a large Chinese news corpus and Internet search data, we conduct an in‐depth out‐of‐sample forecasting study of Consumer Price Index (CPI) with the monthly macroeconomic database. For this purpose, we combine penalized regression and mixed‐frequency data sampling (MIDAS) methods to deal with the mixed‐frequency and high‐dimensional problems. Then we measure the time‐varying contributions of data from different sources and industries via dynamic model averaging. The results show that different types of data all provide enhancement in CPI forecasting, and the inclusion of media and Internet data further improves CPI forecasts' accuracy and timeliness due to their thorough coverage and fast update. In particular, the importance of alternative data is highlighted when the economy experiencing downturn or high uncertainty.