bluuebunny/crossref_metadata_2025 huggingface dataset:
Dysregulated metal ion homeostasis underscores non-canonical function of CD8+ T cell during COVID-19
Authors: Khare Kriti , Chattopadhyay Partha , Devi Priti , Mehta Priyanka , Raina Aakarshan , Liu Chinky Shiu Chen , Tardalkar Kishore , Joshi Meghnad G. , Pandey Rajesh
Published: October 2023

Introduction

Several efforts have been made to describe the complexity of T cell heterogeneity during the COVID-19 disease; however, there remain gaps in our understanding in terms of the granularity within.

Methods

For this attempt, we performed a single-cell transcriptomic analysis of 33 individuals (4 healthy, 16 COVID-19 positive patients, and 13 COVID-19 recovered individuals).

Results

We found CD8+ T cell-biased lymphopenia in COVID-19 patients compared to healthy and recovered individuals. We also found an optimal Th1/Th2 ratio, indicating an effective immune response during COVID-19. Expansion of activated CD4+ T and NK T was detected in the COVID-19-positive individuals. Surprisingly, we found cellular and metal ion homeostasis pathways enriched in the COVID-19-positive individuals compared to the healthy and recovered in the CD8+ T cell populations (CD8+ TCM and CD8+ TEM) as well as activated CD4+ T cells.

Discussion

In summary, the COVID-19-positive individuals exhibit a dynamic T cell mediated response. This response may have a possible association with the dysregulation of non-canonical pathways, including housekeeping functions in addition to the conventional antiviral immune response mediated by the T cell subpopulation. These findings considerably extend our insights into the heterogeneity of T cell response during and post-SARS-CoV-2 infection.
Genomic diversity and taxonomic marker for Arcobacter species
Authors: Zhou Guilan , Gu Yixin , Wang Hairui , Chen Xiaoli , Zhang Xin , Shao Zhujun , Yan Xiaomei , Zhang Jianzhong , Zhang Maojun
Published: October 2023

Arcobacter was recognized as an emerging enteropathogen and controversies regarding its classification persisted. This study aimed to reevaluate the taxonomy of Arcobacter utilizing the 16S rRNA gene, 23S rRNA gene, single-copy orthologous genes, as well as genomic indices such as Average Nucleotide Identity (ANI) and in silico DNA–DNA hybridization (isDDH). The taxonomy of this genus was reevaluated in this study using multiple indices with a dataset of 371 genomes comprising 34 known species and 14 potentially new species. Good discrimination could be achieved only in some species but not for the species with higher sequence similarity using the comparisons of the 16S rRNA gene and 23S rRNA gene sequences. A high-accuracy phylogenomic approach for Arcobacter was established using 84 single-copy orthologous genes obtained through various bioinformatics methods. One marker gene (gene711), which was found to possess the same distinguishing ability as ANI, isDDH, and single-copy orthologous methods, was identified as a reliable locus for inferring the phylogeny of the genus. The effective species classification was achieved by employing gene711 with a sequence similarity exceeding 96%, even for species like A. cloacae, A. lanthieri, and A. skirrowii, which exhibited ambiguous classification using ANI and isDDH. Additionally, excellent subspecies categorizing among A. cryaerophilus could be distinguished using gene711. In conclusion, this framework strategy had the potential advantage of developing rapid species identification, particularly for highly variable species, providing a novel insight into the behavior and characteristics of Arcobacter.
The G protein biased serotonin 5-HT2A receptor agonist lisuride exerts anti-depressant drug-like activities in mice
Authors: Pogorelov Vladimir M. , Rodriguiz Ramona M. , Roth Bryan L. , Wetsel William C.
Published: October 2023

There is now evidence from multiple Phase II clinical trials that psychedelic drugs can exert long-lasting anxiolytic, anti-depressant, and anti-drug abuse (nicotine and ethanol) effects in patients. Despite these benefits, the hallucinogenic actions of these drugs at the serotonin 2A receptor (5-HT2AR) limit their clinical use in diverse settings. Activation of the 5-HT2AR can stimulate both G protein and β-arrestin (βArr) -mediated signaling. Lisuride is a G protein biased agonist at the 5-HT2AR and, unlike the structurally-related lysergic acid diethylamide (LSD), the drug does not typically produce hallucinations in normal subjects at routine doses. Here, we examined behavioral responses to lisuride, in wild-type (WT), βArr1-knockout (KO), and βArr2-KO mice. In the open field, lisuride reduced locomotor and rearing activities, but produced a U-shaped function for stereotypies in both βArr lines of mice. Locomotion was decreased overall in βArr1-KOs and βArr2-KOs relative to wild-type controls. Incidences of head twitches and retrograde walking to lisuride were low in all genotypes. Grooming was decreased in βArr1 mice, but was increased then decreased in βArr2 animals with lisuride. Serotonin syndrome-associated responses were present at all lisuride doses in WTs, but they were reduced especially in βArr2-KO mice. Prepulse inhibition (PPI) was unaffected in βArr2 mice, whereas 0.5 mg/kg lisuride disrupted PPI in βArr1 animals. The 5-HT2AR antagonist MDL100907 failed to restore PPI in βArr1 mice, whereas the dopamine D2/D3 antagonist raclopride normalized PPI in WTs but not in βArr1-KOs. Clozapine, SCH23390, and GR127935 restored PPI in both βArr1 genotypes. Using vesicular monoamine transporter 2 mice, lisuride reduced immobility times in tail suspension and promoted a preference for sucrose that lasted up to 2 days. Together, it appears βArr1 and βArr2 play minor roles in lisuride’s actions on many behaviors, while this drug exerts anti-depressant drug-like responses without hallucinogenic-like activities.
Understanding blood development and leukemia using sequencing-based technologies and human cell systems
Authors: Heuts Branco M. H. , Martens Joost H. A.
Published: October 2023

Our current understanding of human hematopoiesis has undergone significant transformation throughout the years, challenging conventional views. The evolution of high-throughput technologies has enabled the accumulation of diverse data types, offering new avenues for investigating key regulatory processes in blood cell production and disease. In this review, we will explore the opportunities presented by these advancements for unraveling the molecular mechanisms underlying normal and abnormal hematopoiesis. Specifically, we will focus on the importance of enhancer-associated regulatory networks and highlight the crucial role of enhancer-derived transcription regulation. Additionally, we will discuss the unprecedented power of single-cell methods and the progression in using in vitro human blood differentiation system, in particular induced pluripotent stem cell models, in dissecting hematopoietic processes. Furthermore, we will explore the potential of ever more nuanced patient profiling to allow precision medicine approaches. Ultimately, we advocate for a multiparameter, regulatory network-based approach for providing a more holistic understanding of normal hematopoiesis and blood disorders.
K+/Cl− cotransporter 2 (KCC2) and Na+/HCO3− cotransporter 1 (NBCe1) interaction modulates profile of KCC2 phosphorylation
Authors: Pethe Abhishek , Hamze Mira , Giannaki Marina , Heimrich Bernd , Medina Igor , Hartmann Anna-Maria , Roussa Eleni
Published: October 2023

K+/Cl− cotransporter 2 (KCC2) is a major Cl− extruder in mature neurons and is responsible for the establishment of low intracellular [Cl−], necessary for fast hyperpolarizing GABAA-receptor mediated synaptic inhibition. Electrogenic sodium bicarbonate cotransporter 1 (NBCe1) is a pH regulatory protein expressed in neurons and glial cells. An interactome study identified NBCe1 as a possible interaction partner of KCC2. In this study, we investigated the putative effect of KCC2/NBCe1 interaction in baseline and the stimulus-induced phosphorylation pattern and function of KCC2. Primary mouse hippocampal neuronal cultures from wildtype (WT) and Nbce1-deficient mice, as well as HEK-293 cells stably transfected with KCC2WT, were used. The results show that KCC2 and NBCe1 are interaction partners in the mouse brain. In HEKKCC2 cells, pharmacological inhibition of NBCs with S0859 prevented staurosporine- and 4-aminopyridine (4AP)-induced KCC2 activation. In mature cultures of hippocampal neurons, however, S0859 completely inhibited postsynaptic GABAAR and, thus, could not be used as a tool to investigate the role of NBCs in GABA-dependent neuronal networks. In Nbce1-deficient immature hippocampal neurons, baseline phosphorylation of KCC2 at S940 was downregulated, compared to WT, and exposure to staurosporine failed to reduce pKCC2 S940 and T1007. In Nbce1-deficient mature neurons, baseline levels of pKCC2 S940 and T1007 were upregulated compared to WT, whereas after 4AP treatment, pKCC2 S940 was downregulated, and pKCC2 T1007 was further upregulated. Functional experiments showed that the levels of GABAAR reversal potential, baseline intracellular [Cl−], Cl− extrusion, and baseline intracellular pH were similar between WT and Nbce1-deficient neurons. Altogether, our data provide a primary description of the properties of KCC2/NBCe1 protein-protein interaction and implicate modulation of stimulus-mediated phosphorylation of KCC2 by NBCe1/KCC2 interaction—a mechanism with putative pathophysiological relevance.
Goal-directed and habitual control: from circuits and functions to exercise-induced neuroplasticity targets for the treatment of Parkinson’s disease
Authors: Zikereya Talifu , Shi Kaixuan , Chen Wei
Published: October 2023

Parkinson’s disease (PD) is a neurodegenerative disease characterized by motor and cognitive impairments. The progressive depletion of dopamine (DA) is the pathological basis of dysfunctional goal-directed and habitual control circuits in the basal ganglia. Exercise-induced neuroplasticity could delay disease progression by improving motor and cognitive performance in patients with PD. This paper reviews the research progress on the motor-cognitive basal ganglia circuit and summarizes the current hypotheses for explaining exercise intervention on rehabilitation in PD. Studies on exercise mediated mechanisms will contribute to the understanding of networks that regulate goal-directed and habitual behaviors and deficits in PD, facilitating the development of strategies for treatment of PD.
Comparisons and associations among anthropometric indices of first and second division and assistant soccer referees
Authors: Samarein Meysam Rostamzadeh , Samanipour Mohammad Hossein , Asjodi Foad , Shokati Pooya , Fallahi Zanyar , Brownlee Thomas E. , Brito João Paulo , Bragazzi Nicola Luigi , Oliveira Rafael
Published: October 2023

Introduction

Body composition is an important predictor of performance and a key component of health and physical fitness. Therefore, the purposes of this study were to compare soccer referees of the first and second divisions and field assistant referees from Iran and to analyze associations of a body shape index (ABSI), body adiposity index (BAI), abdominal volume index (AVI), body roundness index (BRI), conicity index (ConI), and body mass index (BMI) with body fat percentage (%BF).

Methods

A total of 270 male soccer referees from the first (n = 124) and second (n = 72) divisions and assistant referees (n = 74) participated in this study. Skinfold thickness (measured at the chest, biceps, triceps, subscapular, abdominal, iliac crest, and front thigh), height, weight, hip circumference, and waist circumference were assessed to evaluate waist-to-height ratio (WHtR), %BF, and also ABSI, BRI, BAI, ConI, and AVI according to the ISAK protocol.

Results

The main results indicated differences in WHR, WHtR, ABSI, BRI, AVI, ConI, and BF% with the assistant referees presenting higher values (p < 0.05). When considering the backward selection model, there were some associations with %BF in each group, specifically BMI, BAI, and ABSI in the first division; BMI, WHR, and ABSI in the second division; and BMI in the assistant referee group (all p < 0.05).

Discussion

The present study did not confirm the hypothesis that the first-division referees presented better body composition-related variables than the second division or assistant referees. Instead, it showed that the assistant referees that participated in both divisions showed a tendency to higher values which suggests that the level of division is not a major factor when analyzing body composition.
Passionate hearts, torn loyalties: navigating the interplay between fandom and romance
Authors: Levental Orr , Lev Arey Dalit , Lev Assaf
Published: October 2023

Introduction

The current study presents a thorough investigation of the attitudes and emotions expressed by the spouses and girlfriends of sports fans within the context of their long-term relationships. Its primary objective is to explore the potential ramifications that surface when individuals become deeply invested in a competitive sport, demonstrating intense emotional connections, broad knowledge, unwavering loyalty, and active engagement in fan-related activities.

Methods

The research methodology applied in this study involved conducting semi-structured interviews with a sample of twelve spouses and girlfriends of fans.

Results

The principal findings elucidate four distinct themes that shed light on the intersection of fandom and romantic relationships. These themes include: “that’s what I signed up for”; “fandom as a gendered activity”; “the good, the bad, and the ugly”; and “sports fandom as an addiction.”

Discussion

The study concludes by highlighting the crucial cultural context at work. The social criticism expressed by the interviewees toward non-traditional gender behaviors displayed by their partners serves as a cautionary message. These criticisms aim to preserve and uphold male dominance in sports, thereby reinforcing the notion of their unquestioned supremacy. Consequently, we argue that, within this context, latent aggressive behavior in men is perceived as a strategy to maintain their monopolistic control over sports domains.
Machine learning algorithms for predicting determinants of COVID-19 mortality in South Africa
Authors: Chimbunde Emmanuel , Sigwadhi Lovemore N. , Tamuzi Jacques L. , Okango Elphas L. , Daramola Olawande , Ngah Veranyuy D. , Nyasulu Peter S.
Published: October 2023

Background

COVID-19 has strained healthcare resources, necessitating efficient prognostication to triage patients effectively. This study quantified COVID-19 risk factors and predicted COVID-19 intensive care unit (ICU) mortality in South Africa based on machine learning algorithms.

Methods

Data for this study were obtained from 392 COVID-19 ICU patients enrolled between 26 March 2020 and 10 February 2021. We used an artificial neural network (ANN) and random forest (RF) to predict mortality among ICU patients and a semi-parametric logistic regression with nine covariates, including a grouping variable based on K-means clustering. Further evaluation of the algorithms was performed using sensitivity, accuracy, specificity, and Cohen's K statistics.

Results

From the semi-parametric logistic regression and ANN variable importance, age, gender, cluster, presence of severe symptoms, being on the ventilator, and comorbidities of asthma significantly contributed to ICU death. In particular, the odds of mortality were six times higher among asthmatic patients than non-asthmatic patients. In univariable and multivariate regression, advanced age, PF1 and 2, FiO2, severe symptoms, asthma, oxygen saturation, and cluster 4 were strongly predictive of mortality. The RF model revealed that intubation status, age, cluster, diabetes, and hypertension were the top five significant predictors of mortality. The ANN performed well with an accuracy of 71%, a precision of 83%, an F1 score of 100%, Matthew's correlation coefficient (MCC) score of 100%, and a recall of 88%. In addition, Cohen's k-value of 0.75 verified the most extreme discriminative power of the ANN. In comparison, the RF model provided a 76% recall, an 87% precision, and a 65% MCC.

Conclusion

Based on the findings, we can conclude that both ANN and RF can predict COVID-19 mortality in the ICU with accuracy. The proposed models accurately predict the prognosis of COVID-19 patients after diagnosis. The models can be used to prioritize COVID-19 patients with a high mortality risk in resource-constrained ICUs.
Can we persuade company car drivers to opt out?
Authors: De Wilde Liesbeth , Stas Lara , Savieri Perseverence , Vanhaverbeke Lieselot , Keserü Imre , Macharis Cathy
Published: October 2023

Multiple issues are associated with company cars in the academic debate, such as excessive car use and welfare loss. Company cars, provided by organizations to their employees, are often seen as a subsidy for private car ownership throughout Europe, especially in Belgium. Belgium is the first country in Europe to develop a legal framework in which organizations can replace the company car system with alternative solutions such as a corporate mobility budget. The objective of this study was to gain insight into the intentions of employees to replace their company car with this mobility budget. We have carried out an online survey among 527 company car drivers to predict the financial compensation that is required to replace the company car with more sustainable transport modes. On average, respondents required €683 per month to give up their company car. A stepwise linear regression analysis identified familiarity with alternative transport modes, environmental concern, accessibility, and income as the primary predictors of this financial preference. These variables have been proven to be significant predictors of mode choice as well. The findings can help to identify opportunities for generating a modal shift in organizations.
Factors associated with foodborne pathogens and indicator organisms in agricultural soils
Authors: Cook Camryn , Diekman Clara M. , Weller Daniel L. , Murphy Claire M. , Hamilton Alexis M. , Ponder Monica , Boyer Renee R. , Rideout Steven L. , Maguire Rory O. , Danyluk Michelle D. , Strawn Laura K.
Published: October 2023

Soil can be a route for contamination of fresh fruits and vegetables. While growers routinely manage soil nutrient levels, little research exists on the synergistic or antagonistic effects of soil nutrients on foodborne pathogens. Data on foodborne pathogen prevalence in unamended soils is also relatively limited in literature. This study evaluated foodborne pathogen prevalence (Salmonella, Listeria monocytogenes) and concentration of indicator bacteria (total coliforms, generic Escherichia coli) in agricultural soils, and characterized associations between soil properties (e.g., macro- and micro-nutrient levels) and each microbial target. Three Virginia produce farms, representing different regions and soil types, were sampled four times over 1 year (October 2021–November 2022). For each individual farm visit, composite soil samples were collected from 20 sample sites (25 m2) per farm per visit for microbial and nutrient analysis (n = 240). Samples (25 g) were processed for Listeria spp. and Salmonella using a modified FDA BAM method; samples (5 g) were enumerated for generic E. coli and total coliforms (TC) using Petrifilm. Presumptive Listeria spp. and Salmonella isolates were confirmed by PCR using the sigB and invA genes, respectively. Soil nutrients from each sample were tested and evaluated for their association with each microbial target by Bayesian Mixed Models. Salmonella prevalence was 4.2% (10/240), with 90% (9/10) recovered on Farm C. Listeria spp. and L. monocytogenes prevalence were 10% (24/240) and 2.5% (6/240), respectively. When samples were positive for generic E. coli (107/240), the average concentration was 1.53 ± 0.77 log10 CFU/g. Soil pH was positively associated with L. monocytogenes [Odds Ratio (OR) = 5.5] and generic E. coli (OR = 4.9) prevalence. There was no association between Salmonella prevalence and any evaluated factor; however, Salmonella was 11.6 times more likely to be detected on Farm C, compared to other farms. Results show pathogen prevalence was relatively low in unamended soils, and that factors influencing prevalence and concentration varied by microbial target and farm.
Treatment of recurrent acute tonsillitis—a systematic review and clinical practice recommendations
Authors: Guntinas-Lichius Orlando , Geißler Katharina , Mäkitie Antti A. , Ronen Ohad , Bradley Patrick J. , Rinaldo Alessandra , Takes Robert P. , Ferlito Alfio
Published: October 2023

Background

There is an ongoing debate on the indications for tonsil surgery in both children and adults with recurrent acute tonsillitis. The aim is to provide practical recommendations for diagnostics and treatment for recurrent acute tonsillitis including evidence-based decision making for tonsillectomy.

Methods

A systematic literature search in PubMed, Embase, Web of Science, and ScienceDirect from 2014 until April 2023 resulted in 68 articles. These were the basis for the review and a comprehensive series of consensus statements on the most important diagnostics and indications for both non-surgical and surgical therapy. A consensus paper was circulated among the authors and members of the International Head and Neck Scientific Group until a final agreement was reached for all recommendations.

Results

The differentiation between sore throat and tonsillitis patient episodes is mostly not feasible and hence is not relevant for diagnostic decision making. Diagnostics of a tonsillitis/sore throat episode should always include a classification with a scoring system (Centor, McIssac, FeverPAIN score) to estimate the probability of a bacterial tonsillitis, mainly due to group A streptococcus (GAS). In ambiguous cases, a point-of-care test GAS swab test is helpful. Consecutive counting of the tonsillitis/sore throat episodes is important. In addition, a specific quality of life score (Tonsillectomy Outcome Inventory 14 or Tonsil and Adenoid Health Status Instrument) should be used for each episode. Conservative treatment includes a combination of paracetamol and/or non-steroidal anti-inflammatory drugs. In case of high probability of bacterial tonsillitis, and only in such cases, especially in patients at risk, standard antibiotic treatment is initiated directly or by delayed prescription. Tonsillectomy is indicated and is highly effective if the patient has had ≥7 adequately treated episodes in the preceding year, ≥5 such episodes in each of the preceding 2 years, or ≥3 such episodes in each of the preceding 3 years. An essential part of surgery is standardized pain management because severe postoperative pain can be expected in most patients.

Conclusion

It is necessary to follow a stringent treatment algorithm for an optimal and evidence-based treatment for patients with recurrent acute tonsillitis. This will help decrease worldwide treatment variability, antibiotic overuse, and avoid ineffective tonsillectomy.
The Impact of Multimorbidity on All-Cause Mortality: A Longitudinal Study of 87,151 Thai Adults
Authors: Feng Xiyu , Sarma Haribondhu , Seubsman Sam-Ang , Sleigh Adrian , Kelly Matthew
Published: October 2023

Objectives: To investigate associations between multimorbidity, socio-demographic and health behaviour factors, and their interactions (multimorbidity and these factors) with all-cause mortality among Thai adults.

Methods: Associations between multimorbidity (coexistence of two + chronic diseases) and mortality between 2005 and 2019 were investigated among Thai Cohort Study (TCS) participants (n = 87,151). Kaplan-Meier survival curves estimated and compared survival times. Multivariate Cox proportional hazards models examined associations between risk factors, and interactions between multimorbidity, these factors, and survival.

Results: 1,958 cohort members died between 2005 and 2019. The risk of death was 43% higher for multimorbid people. In multivariate Cox proportional hazard models, multimorbidity/number of chronic conditions, age, long sleep duration, smoking and drinking were all independent factors that increased mortality risk. Women, urbanizers, university education, over 20,000-baht personal monthly income and soybean products consumption lowered risk. The interactions between multimorbidity and these variables (except for female, urbanizers and soybeans intake) also had significant (p < 0.05) impact on all-cause mortality.

Conclusion: The results emphasise the importance of healthy lifestyle and reduced intake of alcohol and tobacco, in reducing premature mortality, especially when suffering from multimorbidity.
Protein Carbonylation as a Biomarker of Oxidative Stress and a Therapeutic Target in Neonatal Brain Damage
Authors: Martínez-Orgado José , Martínez-Vega María , Silva Laura , Romero Angela , de Hoz-Rivera María , Villa María , del Pozo Aarón
Published: October 2023

Oxidative stress (OS) constitutes a pivotal factor within the mechanisms underlying brain damage, for which the immature brain is particularly vulnerable. This vulnerability is caused by the abundance of immature oligodendrocytes in the immature brain, which are highly susceptible to OS-induced harm. Consequently, any injurious process involving OS within the immature brain can lead to long-term myelination impairment. Among the detrimental repercussions of OS, protein carbonylation stands out as a prominently deleterious consequence. Noteworthy elevation of protein carbonylation is observable across diverse models of neonatal brain injury, following both diffuse and focal hypoxic–ischemic insults, as well as intraventricular hemorrhage, in diverse animal species encompassing rodents and larger mammals, and at varying stages of brain development. In the immature brain, protein carbonylation manifests as a byproduct of reactive nitrogen species, bearing profound implications for cell injury, particularly in terms of inflammation amplification. Moreover, protein carbonylation appears as a therapeutic target for mitigating neonatal brain damage. The administration of a potent antioxidant, such as cannabidiol, yields substantial neuroprotective effects. These encompass the reduction in cerebral damage, restoration of neurobehavioral performance, and preservation of physiological myelination. Such effects are linked to the modulation of protein carbonylation. The assessment of protein carbonylation emerges as a reliable method for comprehending the intricate mechanisms underpinning damage and neuroprotection within neonatal brain injury.
Zebrafish Model Insights into Mediterranean Diet Liquids: Olive Oil and Wine
Authors: Silva Paula , Rodríguez-Pérez María , Burgos-Ramos Emma
Published: October 2023

In this review, we explored the potential of a zebrafish model to investigate the antioxidant effects of key components of the Mediterranean diet, namely, olive oil and wine, in the context of preventing age-related diseases, particularly cardiovascular conditions. This paper explores the spectrum of observational studies to preclinical investigations and ultimately converges toward potential translational insights derived from animal experimentation. This review highlights the potential and underutilization of zebrafish as an experimental model in this domain. We highlighted the genetic proximity of zebrafish to humans, offering a unique opportunity for translational insights into the health benefits of olive oil and wine. Indeed, we wanted to focus on the potential of zebrafish to elucidate the health benefits of olive oil and wine while calling for continued exploration to unlock its full potential to advance our knowledge of age-related disease prevention within the Mediterranean diet framework.
The Soviet and Stalinist Works of the Michell Wolfson Jr. Collection
Authors: Fochessati Matteo
Published: October 2023

This paper offers a survey of the Soviet propaganda works collected by Mitchell (Micky) Wolfson Jr. since there 1980s and now preserved at the Wolfsonian—FIU (Florida International University) in Miami Beach and at the Wolfsoniana—Palazzo Ducale Fondazione per la Cultura in Genoa. The first collection to include the art of the regimes in a larger panorama of cultural production, the Wolfsonian offers, through a critical interpretation of the Soviet propaganda works within linguistic pluralism, a clear and immediate visual narrative of the history of the twentieth century.
A Layered Hybrid Oxide–Sulfide All-Solid-State Battery with Lithium Metal Anode
Authors: Hüttl Juliane , Zapp Nicolas , Tanikawa Saoto , Nikolowski Kristian , Michaelis Alexander , Auer Henry
Published: October 2023

Different classes of solid electrolytes for all-solid-state batteries (ASSB) are currently being investigated, with each of them suitable for a different ASSB concept. Their combination in hybrid battery cells enables the use of their individual benefits while mitigating their disadvantages. The cubic stuffed garnet Li7La3Zr2O12 (LLZO), for example, is stable in contact with metallic lithium but has only moderate ionic conductivity, whereas the thiophosphate Li10SnP2S12 (LSPS) is processable using conventional battery manufacturing technologies and has an excellent lithium-ion conductivity but an inferior electrochemical stability. In this work, we, therefore, present a layered hybrid all-solid-state full-cell concept that accommodates a lithium metal anode, a LiNi0.8Co0.1Mn0.1O2-based composite cathode with an LSPS catholyte (LSPS/NCM811) and a sintered monolithic LLZO separator. The electrochemical stability of LLZO and LSPS at cathodic potentials (up to 4.2 V) was investigated via cyclic voltammetry in test cells, as well as by cycling half cells with LSPS or a mixed LSPS/LLZO catholyte. Furthermore, the pressure-dependency of the galvanostatic cycling of a Li | LLZO | LSPS/NCM811 full cell was investigated, as well as the according effect of the Li | LLZO interface in symmetric test cells. An operation pressure of 12.5 MPa was identified as the optimal value, which assures both sufficient inter-layer contact and impeded lithium penetration through the separator and cell short-circuiting.
Clinical Management and Therapy of Precocious Puberty in the Sapienza University Pediatrics Hospital of Rome, Italy
Authors: Micangeli Ginevra , Paparella Roberto , Tarani Francesca , Menghi Michela , Ferraguti Giampiero , Carlomagno Francesco , Spaziani Matteo , Pucarelli Ida , Greco Antonio , Fiore Marco , Tarani Luigi
Published: October 2023

Puberty identifies the transition from childhood to adulthood. Precocious puberty is the onset of signs of pubertal development before age eight in girls and before age nine in boys, it has an incidence of 1/5000–1/10,000 with an F:M ratio ranging from 3:1 to 20:1. Precocious puberty can be divided into central, also known as gonadotropin-dependent precocious puberty or true precocious puberty, and peripheral, also recognized as gonadotropin-independent precocious puberty or precocious pseudopuberty. Thus, the main aim of this narrative report is to describe the standard clinical management and therapy of precocious puberty according to the experience and expertise of pediatricians and pediatric endocrinologists at Policlinico Umberto I, Sapienza University of Rome, Italy. In the suspicion of early sexual maturation, it is important to collect information regarding the age of onset, the speed of maturation of secondary sexual features, exposure to exogenous sex steroids and the presence of neurological symptoms. The objective examination, in addition to the evaluation of secondary sexual characteristics, must also include the evaluation of auxological parameters. Initial laboratory investigations should include serum gonadotropin levels (LH and FSH) and serum levels of the sex steroids. Brain MRI should be performed as indicated by the 2009 Consensus Statement in all boys regardless of chronological age and in all girls with onset of pubertal signs before 6 years of age. The gold standard in the treatment of central precocious puberty is represented by GnRH analogs, whereas, as far as peripheral forms are concerned, the triggering cause must be identified and treated. At the moment there are no reliable data establishing the criteria for discontinuation of GnRH analog therapy. However, numerous pieces of evidence suggest that the therapy should be suspended at the physiological age at which puberty occurs.
QoS-Aware and Energy Data Management in Industrial IoT
Authors: Abdullah Yarob , Movahedi Zeinab
Published: October 2023

Two crucial challenges in Industry 4.0 involve maintaining critical latency requirements for data access and ensuring efficient power consumption by field devices. Traditional centralized industrial networks that provide rudimentary data distribution capabilities may not be able to meet such stringent requirements. These requirements cannot be met later due to connection or node failures or extreme performance decadence. To address this problem, this paper focuses on resource-constrained networks of Internet of Things (IoT) systems, exploiting the presence of several more powerful nodes acting as distributed local data storage proxies for every IoT set. To increase the battery lifetime of the network, a number of nodes that are not included in data transmission or data storage are turned off. In this paper, we investigate the issue of maximizing network lifetime, and consider the restrictions on data access latency. For this purpose, data are cached distributively in proxy nodes, leading to a reduction in energy consumption and ultimately maximizing network lifetime. To address this problem, we introduce an energy-aware data management method (EDMM); with the goal of extending network lifetime, select IoT nodes are designated to save data distributively. Our proposed approach (1) makes sure that data access latency is underneath a specified threshold and (2) performs well with respect to network lifetime compared to an offline centralized heuristic algorithm.
Thermodynamics of the Ramsey Zone
Authors: de Assis Rogério Jorge , Diniz Ciro Micheletti , de Almeida Norton Gomes , Villas-Bôas Celso Jorge
Published: October 2023

We studied the thermodynamic properties such as the entropy, heat (JQ), and work (JW) rates involved when an atom passes through a Ramsey zone, which consists of a mode field inside a low-quality factor cavity that behaves classically, promoting rotations on the atomic state. Focusing on the atom, we show that JW predominates when the atomic rotations are successful, maintaining its maximum purity as computed by the von Neumann entropy. Conversely, JQ stands out when the atomic state ceases to be pure due to its entanglement with the cavity mode. With this, we interpret the quantum-to-classical transition in light of the heat and work rates. Besides, we show that, for the cavity mode to work as a Ramsey zone (classical field), several photons (of the order of 106) need to cross the cavity, which explains its classical behavior, even when the inside average number of photons is of the order of unity.
Biophotons: New Experimental Data and Analysis
Authors: Benfatto Maurizio , Pace Elisabetta , Davoli Ivan , Francini Roberto , De Matteis Fabio , Scordo Alessandro , Clozza Alberto , De Paolis Luca , Curceanu Catalina , Grigolini Paolo
Published: October 2023

Biophotons are an ultra-weak emission of photons in the visible energy range from living matter. In this work, we study the emission from germinating seeds using an experimental technique designed to detect light of extremely small intensity. The emission from lentil seeds and single bean was analyzed during the whole germination process in terms of the different spectral components through low pass filters and the different count distributions in the various stages of the germination process. Although the shape of the emission spectrum appears to be very similar in the two samples used in our experiment, our analysis can highlight the differences present in the two cases. In this way, it was possible to correlate the various types of emissions to the degree of development of the seed during germination.
On the Optimal Error Exponent of Type-Based Distributed Hypothesis Testing
Authors: Tong Xinyi , Xu Xiangxiang , Huang Shao-Lun
Published: October 2023

Distributed hypothesis testing (DHT) has emerged as a significant research area, but the information-theoretic optimality of coding strategies is often typically hard to address. This paper studies the DHT problems under the type-based setting, which is requested from the popular federated learning methods. Specifically, two communication models are considered: (i) DHT problem over noiseless channels, where each node observes i.i.d. samples and sends a one-dimensional statistic of observed samples to the decision center for decision making; and (ii) DHT problem over AWGN channels, where the distributed nodes are restricted to transmit functions of the empirical distributions of the observed data sequences due to practical computational constraints. For both of these problems, we present the optimal error exponent by providing both the achievability and converse results. In addition, we offer corresponding coding strategies and decision rules. Our results not only offer coding guidance for distributed systems, but also have the potential to be applied to more complex problems, enhancing the understanding and application of DHT in various domains.
Lactic Acid Production from Cow Manure: Technoeconomic Evaluation and Sensitivity Analysis
Authors: Garrido Ricard , Cabeza Luisa F. , Falguera Víctor
Published: October 2023

Recently, the industrial focus has shifted to renewable raw materials due to the exhaustion and rising pressures about environmental and political issues. Lignocellulosic biowaste can be derived from a range of sources, such as animal manure, forestry waste, and agricultural waste, and it can be transformed into lactic acid through a biochemical process. There are 942.63 million cattle in the world and annually generate 3.7 billion tons of manure, which could be used to produce lactic acid. The economic viability of a lactic acid plant from cow manure has not yet been determined and is, thus, considered in this study. Using the modeling program Aspen Plus data and other sources, as well as collecting all economic inputs, the feasibility analysis of a lactic acid plant handling cow manure is assessed in this paper. Three scenarios are calculated to check the feasibility depending on the plant size: scenario I handles 1,579,328 t·year−1, scenario II handles 789,664 t·year−1, and scenario III handles 315,865 t·year−1. The results demonstrate that treating the tested lignocellulosic biomass for the manufacture of lactic acid is economically feasible because the economic analysis shows positive net present values for scenarios I, II, and III. The technoeconomic analysis reveals that the minimum lactic acid selling price for scenario I is 0.945 EUR·kg−1, which is comparable to the cost of commercial lactic acid produced from starch feedstock. Scenario II achieves a minimum selling price of 1.070 EUR·kg−1, and scenario III 1.289 EUR·kg−1. The sensitivity analysis carried out reveals that the factor with the biggest impact on the NPV is the yield. Moreover, this study provides a model of industrial application and technoeconomic evaluation for lactic acid production from cow manure.
Optimizing XGBoost Performance for Fish Weight Prediction through Parameter Pre-Selection
Authors: Hamzaoui Mahdi , Aoueileyine Mohamed Ould-Elhassen , Romdhani Lamia , Bouallegue Ridha
Published: October 2023

Fish play a major role in the human nutritional system, and farmers need to know the accurate prediction of fish weight in order to optimize the production process and reduce costs. However, existing prediction methods are not efficient. The formulas for calculating fish weight are generally designed for a single species of fish or for species of a similar shape. In this paper, a new hybrid method called SFI-XGBoost is proposed. It combines the VIF (variance inflation factor), PCC (Pearson’s correlation coefficient), and XGBoost methods, and it covers different fish species. By applying GridSearchCV validation, normalization, augmentation, and encoding techniques, the obtained results show that SFI-XGBoost is more efficient than simple XGBoost. The model generated by our approach is more generalized, achieving accurate results with a wide variety of species. Using the r2_score evaluation metric, SFI-XGBoost achieves an accuracy rate of 99.94%.
Relationship between Physicochemical, Techno-Functional and Health-Promoting Properties of Fiber-Rich Fruit and Vegetable By-Products and Their Enhancement by Emerging Technologies
Authors: Manthei Alina , López-Gámez Gloria , Martín-Belloso Olga , Elez-Martínez Pedro , Soliva-Fortuny Robert
Published: October 2023

The preparation and processing of fruits and vegetables produce high amounts of underutilized fractions, such as pomace and peel, which present a risk to the environment but constitute a valuable source of dietary fiber (DF) and bioactive compounds. The utilization of these fiber-rich products as functional food ingredients demands the application of treatments to improve their techno-functional properties, such as oil and water binding, and health-related properties, such as fermentability, adsorption, and retardation capacities of glucose, cholesterol, and bile acids. The enhancement of health-promoting properties is strongly connected with certain structural and techno-functional characteristics, such as the soluble DF content, presence of hydrophobic groups, and viscosity. Novel physical, environmentally friendly technologies, such as ultrasound (US), high-pressure processing (HPP), extrusion, and microwave, have been found to have higher potential than chemical and comminution techniques in causing desirable structural alterations of the DF network that lead to the improvement of techno-functionality and health promotion. The application of enzymes was related to higher soluble DF content, which might be associated with improved DF properties. Combined physical and enzymatic treatments can aid solubilization and modifications, but their benefit needs to be evaluated for each DF source and the desired outcome.
Roles of Parental Psychological Flexibility, Self-Compassion, and Self-Efficacy in Affecting Mental Health and Quality of Life in Parents of Children with Eczema
Authors: Chong Yuen Yu , Kwan Joycelyn Yee Man , Yau Pui Tik , Cheng Ho Yu , Chien Wai Tong
Published: October 2023

Parents of young children with eczema often experience adverse mental health consequences, including depression, anxiety, stress, and a reduced health-related quality of life (HRQoL), due to the unpredictable nature of flare-ups and exacerbations. This study investigated the roles of psychological flexibility, self-compassion, and self-efficacy in fostering parental mental health outcomes and HRQoL while caring for children diagnosed with eczema. Baseline data from an ongoing clinical trial examining the effects of a family acceptance-and-commitment-therapy-based eczema management program (FACT-EMP) on parent–child dyads affected by eczema (N = 110 dyads, 75.5% mothers; 66.4% boys) were analyzed using adjusted hierarchical regression analyses. The findings indicate that psychological inflexibility was significantly associated with symptoms of anxiety, depression, stress, and HRQoL. Self-compassion was significantly linked to all assessed mental health outcomes, whereas self-efficacy showed a significant association only with symptoms of depression. These results underscore the significance of promoting parental psychological flexibility and self-compassion through acceptance and commitment therapy and compassion-based approaches to enhance mental health and quality of life while managing children’s eczema.
Physicochemical Properties of Geographical Indication (GI) Sweet Cherries in China and Their Influencing Factors of Cultivar, Climate Type, and Soil Condition
Authors: Nie Ying , Huang Jiazhang , Liu Rui , Wang Pei , Liu Peng , Lu Man , Sun Junmao
Published: October 2023

As one of the fruits widely planted in China, the quality of sweet cherries is affected by various factors. This study aims to investigate the characteristics of geographical indication (GI) sweet cherries grown in China and to analyze the effects of cultivars, climate types, and soil conditions on their quality traits. Twenty-two parameters of nine cherry samples and their planted soil properties were analyzed through a descriptive analysis and correlation analysis. There were significant differences in the physiochemical traits. Notable positive correlations between the fruit weight and its size, rate of edibility, and flavonoid content were shown. The Univariate-General Line Model exhibited that weight, soluble solids content (SSC), titratable acidity (TA), and total phenolic content (TPC) were mainly influenced by both the cultivar and climate type, while only the cultivar affected the maturity index (MI). Soil condition parameters were significantly different for each sample. Based on the established linear regression models, it was found that soil P had a positive impact on SSC and TA, but a negative effect on TPC (p < 0.05). On the other hand, soil K had a negative effect on TA but a positive impact on TPC (p < 0.05).
Exploring the Chemical Content of Primula veris L. subsp. veris Wild-Growing Populations along a Climate Gradient: An HPLC-PDA-MS Quality Assessment of Flowers, Leaves and Roots for Sustainable Exploitation
Authors: Stefanis Ilias , Chatzopoulou Paschalina , Krigas Nikos , Karioti Anastasia
Published: October 2023

Primula veris (cowslip) is an important medicinal–aromatic plant used traditionally for its expectorant and anti-inflammatory properties, as well as a valuable horticultural plant with ornamental value and agroalimentary interest (edible flowers and leaves). With extensive illegal harvesting across northern Greece to date, the long-term survival of Greek cowslip wild-growing populations seems compromised. With the aim to characterize the phytochemical content of locally adapted native genotypes of P. veris subsp. veris, we examined samples from 13 wild-growing populations sourced from 8 mountain areas along a longitudinal gradient of northern Greece. Flowers, leaves, and roots were separately evaluated with HPLC-PDA-MS for their chemical content to select the genotypes associated with the best phytochemical traits. The flowers were found to contain mainly flavonoids, isorhamnetin, quercetin, and kaempferol triglycosides, with varied population contents, generally higher in northwestern population samples with a colder and more humid climate; however, all in line with the European Medicines Agency’s (EMA) reports. The leaves were characterized by the prevalence of kaempferol and quercetin triglycosides, being generally higher than that of the flowers. In the roots, saponins were detected in relatively low percentages, and the phenolic glycosides were found up to nearly 2%. The results of this study suggest a potential specificity of the marginal Greek genotypes being at the edge of the species’ native distribution range in Europe and Asia. The phytochemical characterization herein supports the domestication process of Greek native cowslip genotypes. In turn, this may alleviate the overharvesting pressure in wild populations, thus contributing to species conservation and offering an incentive for farmers to sustainably cultivate at local scales well-adapted indigenous genotypes of high value.