bluuebunny/crossref_metadata_2025 huggingface dataset:
Animal Recognition Application System for Early Childhood Using Augmented Reality Method
Authors: Reynaldo Heral , Suprianto  , Indahyani Uce
Published: September 2022

Currently the level of interest in reading in children is very low. They prefer to play gadgets rather than reading books to add insight and knowledge. By reading, they can see and understand the contents of the reading. Especially learning about various animals around the world, not those around the house or surroundings, which they may not recognize. The aim of the researcher is to help children to learn about the animals around them and the world. Instead of children just playing with gadgets, it's better if their gadgets are used as learning tools. The marker-based Augmented Reality (AR) method is used as a method of recognizing the animal, because it can provide an overview of 3D visual objects that can provide information to make it more attractive to children. And AR is able to provide appropriate information in the real world. This is because Augmented Reality can provide interactive and more efficient learning, because children not only learn theoretically, but also see objects being taught in 3 dimensions. In the study, it can be seen that Augmented Reality can be used as a medium for introducing animals around the house and the world, it is hoped that this application can then be developed for various platforms and can also contain more information about all animals in the world.
Use of Shells Waste Filler in Pavement Layer Using Lapen (Macadam Penetration Layer)
Authors: Ayunaning Kholidia , P Avisha Gita , Juliati Kristin
Published: September 2022

Damage to asphalt construction has made several attempts to increase the strength of asphalt construction, one of which is by utilizing shell waste as an asphalt mixture (filler) which is expected to increase the strength and durability of the pavement. The addition of filler shell waste with varying levels of 0%, 5%, 10%, 15%, 20%, and 25% is taken from the percentage of fine aggregate. Based on the results of the research conducted, the results of the Marshall Test for asphalt mixtures with the best variations of shell waste filler material and meeting the requirements of the General Specifications of Highways were found at a filler content of 0% with an immersion time of 30 minutes, with a VMA (Void in Mineral Aggregate) value. ) 66.07%, VFA (Void Filled with Aggregate) value 66.35%, VIM (Void in Mix) value 21.49%, stability value 1097.15 kg, Flow value 3.04 mm and MQ (Marshall Quotient) value 360.62 kg/mm.
Hot Water Looping System to Control Temperature of Drug Production Based Arduino
Authors: Putra I Dewa Made Juniarta , Sulistiyowati Indah , Syahrorini Syamsudduha
Published: September 2022

The temperature regulation in the drug production room is intended as a way to maintain the quality of the drug in accordance with the Good Manufacturing Practices (CPOB). In order to regulate the room temperature, one of the supporters is hot water. So a looping hot water system is needed which will be circulated to the AHU (Air Handling Unit) machine. To get hot water that is circulated automatically, a looping hot water system is made. This control system is made using Arduino Uno as a controller for the looping hot water system which will later control all supporting devices, the HC-SR04 ultrasonic sensor to read the water level in the tank, the DS18B20 sensor to read the water temperature, 16x2 LCD, 4x4 keypad, relays, heating components and a pump to fill the water tank automatically and circulate hot water. From the test results of installing this system with 5 times of data collection, it can be seen that the process of filling the water tank, water heating, and water circulation is going well with the accuracy of the ultrasonic sensor HC-SR04 reaching 96% and the DS18B20 sensor having an accuracy rate of up to 97%. Results This can make the drug production process run well because the room temperature is maintained.
The Effect Of Planting Distance and Dosage Of Fertilizing Cow Manage On Production Products Red Rosella (Hibiscus sabdariffa L.)
Authors: Iswanto Mohamad , Abror M
Published: September 2022

This study aims to determine the effect of spacing and application of manure on the production of Red Roselle (Hibiscus sabdariffa L.). The research was carried out in three months, from April to June 2021. This research was carried out using a factorial Randomized Group Design (RAK). Namely, the first factor is the spacing between (i) 20 x 10 cm (J1); (ii) 20 x 20 cm (J2); 20 x 30 cm (J3). The second factor includes (i) 0 ton/hectare (D1); (ii) 5 tons/ha (D2); (iii) 10 tons/ha (D3). Produced 9 treatment combinations and each was repeated 3 times resulting in 27 experimental units. The variables in this study were plant length, number of leaves, flower wet weight and flower dry weight. The data in this study used analysis of variance (ANOVA) if there was a significant difference, then the Honest Significant Difference (BNJ) test was continued at the 5% confidence level. The results showed that there was a significant interaction on the observed variables of plant growth, namely plant height at 41 DAP. In the observation variable the number of leaves there was a significant interaction at the age of 34 DAP and a very significant effect on the spacing treatment at 41 DAP and 48 DAP. However, the observation of plant production showed no significant response to the wet weight of flowers and dry weight of flowers.
Hijaiyah Learning Media Using Augmentend Reality TK Masyitoh 12
Authors: SM Mohammad Doni Ferdiansah , Azizah Nuril Lutvi
Published: September 2022

Indonesia is one of the largest Islamic countries in the world. Al-Quran learning is an early learning that must be implemented from an early age. The introduction of Hijaiyah letters is one of them for early learning, but some children aged 4 to 7 years prefer and are engrossed in their smartphones other than learning to read the Koran. Thus, it is very difficult for children to distinguish the hijaiyah letters. In the era of technology, of course, everyone is familiar with 3dimensional (3D) technology, now comes a new technology called Augmented Reality, namely technology that can combine the real world with the virtual world which is responded to through electronic devices. With the development of today's technology, as well as finding information is difficult. There have been many ways that have been done by previous researchers to create learning media to foster interest in learning hijaiyah letters. one of them is using Augmented Reality (AR) by mixing hijaiyah letters which are expected to be in 3 dimensions to recognize the differences in letters with android interactive educational applications in this application there are also sounds for children to understand the differences in hijaiyah letters in the letters.
Development of Web Service and Telegram Bot for Location-Based Health Service Information System
Authors: Djoelianto Agoeng Dwi , Kautsar Irwan Alnarus , Rosid Mochamad Alfan
Published: September 2022

In the era of technological advances and the current era, the city of Sidoarjo is known as an industrial city and is also known as a densely populated city because many immigrants seek work in Sidoarjo City. The Sidoarjo City Government also pays attention to the health level of its people, to promote better health services, a forum or media is needed to obtain information on the location of health services in Sidoarjo City, therefore the people of Sidoarjo need a location-based health service information system application. The existence of the covid-19 pandemic is also an impetus for writers to develop web services and telegram bots which will later be used as tools to search for health care places. The development uses the webhook method which is used to design the telegram bot and performs system testing using BlackBox testing. The development of this web service is used for hospital and polyclinic data processing where the data format used is JSON and uses the Python programming language and the Flask Restful framework, which later utilizes the API using the telegram bot as a data source, and the function of the telegram bot as a data search tool. hospitals and polyclinics were developed using the botogram module and the python programming language. After developing and testing the web service system and the telegram bot can be used as originally planned and can help find health service places and their locations, where the web service is used for processing hospital and poly data while the telegram bot can be used to search for hospital and poly data.
Forecasting Thinner Number 7 Sales Using ARIMA (Autoregressive Integrated Moving Average) Method
Authors: Santoso Luhur Arif , Putra Boy Isma , Jakaria Ribangun Bamban , Sari W Indah Apriliana
Published: September 2022

PT. DCN Indonesia is a paint distributor company. In the provision of paint and all devices including thinner often require a keepatan in its provider. This research is done to obtain thinner demand forecasting and determine the amount of stock that must be available in storage in order to at any time meet the impromptu demand that is one of the problems. ARIMA is a forecasting method that is suitable for such cases because it has advantages in the use of data with fluctuating patterns. The results achieved in this study got the ARIMA model (1, 0, 4) which means that the forecasting results are influenced by the results of observations one month ago san error four months ago. obtained the results of the sale of thinner of 8 liters and after going through the calculation of safety stock resulted in inventory planning calculations of 120 liters.
Determining the Production Amount of Tofu Using Mamdani Method (Case Study: UD. Eko Jaya Pasuruan Tahu Factory)
Authors: Santoso Wahyu , Indahyanti Uce
Published: September 2022

Lots of problems that contain uncertainty arise in this world. Fuzzy logic is one of the methods created to analyze systems that contain these uncertainties. In this study, the author uses the Mamdani method or often also known as the Min-Max method which is an application of the fuzzy method. The purpose of this study was to determine the amount of tofu production at UD. Eko Jaya Pasuruan by using the MinMax (Mamdani) method. The data used is the number of requests and the amount of product inventory at UD. Eko Jaya in June 2022. After that, data analysis was carried out using the Mamdani fuzzy method to determine the amount of production. The design of the system to obtain the output is carried out in several stages, including (a) forming fuzzy sets, (b) application of implication functions, (c) forming rules, and (d) affirmation (defuzzification). In this study, defuzzification was carried out using the centroid method. From the results of data processing that has been carried out, using input variables in June 2022, namely the number of requests of 14,000 pcs and the amount of inventory of 3000 kg each producing an output of 13,808 pcs.
Automated ground-penetrating-radar post-processing software in R programming
Authors: Cook Samantha , Torres Marissa , Lamie Nathan , Perren Lee , Slone Scott , Jones Bonnie
Published: September 2022

Ground-penetrating radar (GPR) is a nondestructive geophysical technique used to create images of the subsurface. A major limitation of GPR is that a subject matter expert (SME) needs to post-process and interpret the data, limiting the technique’s use. Post-processing is time-intensive and, for detailed processing, requires proprietary software. The goal of this study is to develop automated GPR post-processing software, compatible with Geophysical Survey Systems, Inc. (GSSI) data, in open-source R programming. This would eliminate the need for an SME to process GPR data, remove proprietary software dependencies, and render GPR more accessible. This study collected GPR profiles by using a GSSI SIR4000 control unit, a 100 MHz antenna, and a Trimble GPS. A standardized method for post-processing data was then established, which includes static data removal, time-zero correction, distance normalization, data filtering, and stacking. These steps were scripted and automated in R programming, excluding data filtering, which was used from an existing package, RGPR. The study compared profiles processed using GSSI software to profiles processed using the R script developed here to ensure comparable functionality and output. While an SME is currently still necessary for interpretations, this script eliminates the need for one to post-process GSSI GPR data.
El valor de la Red de Espacios Naturales Protegidos de Andalucía para el sector turístico: ¿un reto para el desarrollo territorial rural?
Authors: Sánchez-Sánchez Francisca J. , Sánchez-Sánchez Ana M.
Published: September 2022

En las investigaciones sobre turismo y espacios naturales protegidos, se manifiestan dos tendencias, en una el turismo se muestra como elemento que contribuye al bienestar local y al desarrollo socioeconómico, mientras que otra, vincula el turismo en dichos espacios, a una normativa excesivamente restrictiva que dificulta la actividad turística y con ello el desarrollo rural. Este trabajo, contribuye a estas investigaciones y plantea el objetivo de determinar la relación existente entre los espacios naturales protegidos, el turismo de naturaleza y su impacto como eje vertebrador para el desarrollo rural. Para ello, se analizan los espacios protegidos de la región de Andalucía (España), aplicándose para el estudio técnicas estadísticas de Análisis Multivariante. Se identifican el dinamismo turístico, laboral y socioeconómico, la eficacia turística, la calidad de los recursos naturales, las actividades de fomento e inversión territorial y los recursos turísticos como factores que caracterizan los espacios naturales protegidos regionales. Dichos factores tienen un impacto positivo en el 75% del territorio, lo que muestra que estos espacios son activos reales del desarrollo rural y local de la región. El turismo como actividad se beneficia de los recursos y valores de estas zonas, contribuyendo al desarrollo territorial de áreas rurales necesitadas de revitalización.
EL VALOR DE UN AJUSTE OCLUSAL, ¿POR QUÉ, CÓMO, CUÁNDO?: REPORTE DE CASO
Authors: Garcia Cahuana Leslie Nicole Erika , Martinez Aparcana Joselin Harley , Atoche Socola Katherine Joselyn , Figueroa Pastrana David Juan
Published: September 2022

El objetivo de una odontología optima es llegar a estabilizar al sistema estomatognático (dientes, periodonto, músculos y articulación temporomandibular). Todos estos deben trabajar en armonía, ya que juntos proporcionan un óptimo cuidado desde el diagnostico pasando por la planificación hasta el tratamiento. Sin embargo, en la actualidad muchos clínicos toman poca importancia a la identificación de contactos prematuros y/o interferencias antes de realizar cualquier tratamiento odontológico, el cual debería tomarse en cuenta para brindar una mejora en la estabilidad en el cierre mandibular, correcta guía anterior y canina en los movimientos mandibulares.

El   presente   caso   clínico   describe   el   tratamiento de un paciente con diagnóstico de desorden funcional oclusal por contacto prematuro cuyo tratamiento consistió en realizar un ajuste oclusal por desgaste selectivo, siguiendo la técnica descrita por el autor Klineberg, con el objetivo de preservar al máximo la estructura dentaria manteniendo un control durante el ajuste oclusal y devolviendo el mayor número de contactos puntiformes y simétricos.
JIP Focuses on Equipment Reliability in Subsea Production Systems
Authors: Carpenter Chris
Published: September 2022

This article, written by JPT Technology Editor Chris Carpenter, contains highlights of paper OTC 30219, “SEAR JIP: A Success Story of Collaboration and How To Improve Equipment Reliability on Subsea Production Systems,” by Adriana Botto, Wood; Manish Tomar, Chevron; and Stuart Ferrier, ConocoPhillips, et al. The paper has not been peer reviewed. Copyright 2020 Offshore Technology Conference. Reproduced by permission.

The Subsea Equipment Australia Reliability (SEAR) joint industry project (JIP) is a partnership led by Wood with participation from a group of operators including Chevron Australia, ConocoPhillips, Inpex, Santos, Shell Australia, and Woodside. Now delivering Phase 6, the JIP is focused on collaboration and knowledge-sharing to improve the competitiveness of Australia’s oil and gas industry by addressing critical challenges associated with premature subsea-equipment failure. The complete paper provides an overview of the JIP and outlines lessons learned and value created.

Background

The SEAR JIP was initiated in 2014 with an aim of generating significant cost savings by improving subsea-equipment reliability and design for Australian operations, a goal best achieved through collaboration and knowledge-sharing. A reliability database was developed to collect offshore-operations failure information from SEAR members. The database provides a low-cost/high-value method of capturing lessons learned for subsea-equipment performance in Australia. A complementary test program, Transforming Australian Subsea Equipment Reliability (TASER), is under way to model innovative technologies under variable environments to validate equipment advancements.

Phase 6 of the JIP aims to continue populating the reliability database while addressing two major industry challenges: the effect of marine fouling affecting equipment operability, and unwanted gas in subsea controls umbilicals. The outcome of this phase should provide opportunities for standardization, life extension, and development of new technologies.

The JIP plans to issue an industry recommended practice in 2022 harnessing the lessons learned. This recommended practice will identify root causes of equipment failure and recommend material selection and mechanical design requirements for different environmental conditions. This will enable an improvement in equipment availability and a reduction in operating expenditures by minimizing offshore intervention to address failed equipment.
All-Electric Boosting-Control System Simplifies, Improves Operating Processes
Authors: Carpenter Chris
Published: September 2022

This article, written by JPT Technology Editor Chris Carpenter, contains highlights of paper OTC 31943, “Introduction to New Technology Applications, Data-Acquisition Capabilities, and Features of the All-Electric Boosting Control System,” by Kjetil Bergtun, Carsten Mahler, and Trond Melheim, OneSubsea. The paper has not been peer reviewed. Copyright 2022 Offshore Technology Conference. Reproduced by permission.

The complete paper describes an all-electric system (AES) and how its implementation will simplify operating processes, reduce topside and subsea weight and cost, and lower the risk of hazardous fluids escaping into the ocean. The authors place special focus on the electrical actuators that were introduced in this project as well as the challenges faced during project execution.

Vigdis Field

The Vigdis field was discovered in 1986 between the Snorre, Statfjord, and Gullfaks fields in the Tampen area of the North Sea. The development consisted of seven subsea templates and two satellite wells producing to the Snorre A (SNA) facility, which contains a dedicated processing module for Vigdis.

In 2002 the plan for development and operation of the Vigdis extension was approved. An unprocessed wellstream is transported from Vigdis to the Snorre A platform by two flowlines. Stabilized oil is transported by pipeline from Snorre A to Gullfaks A for storage and export (offloading). The second platform (SNB) in the Snorre field is 11 km north of SNA. The Snorre field is approximately 130 km from the Norwegian coast, nearly at the same latitude as Florø.

When the Vigdis field came onstream in 1997, recoverable resources were estimated at 200 million bbl of oil. The field has now produced 394 million bbl, and recoverable resources have been increased to 455 million bbl of oil.

Production from the field was limited by the capacity of the production lines and pressure drop across the topside chokes. Reservoir deliverability was limited by low reservoir pressure in some parts of the field, together with increasing water cut, leading to reduced energy into the system, which in turn caused dropping wellhead pressures.
Automation and Closed-Loop Systems Reduce HSE Risks
Authors: Carpenter Chris
Published: September 2022

This article, written by JPT Technology Editor Chris Carpenter, contains highlights of paper OTC 31985, “Reducing HSE Risks Through Automation and Closed-Loop Systems,” by Simon Smith, Olof Nilsson, SPE, and Aksel Skåland, SPE, FourPhase. The paper has not been peer reviewed. Copyright 2022 Offshore Technology Conference. Reproduced by permission.

Solids production in produced fluids is an industrywide challenge, incurring major costs to operators through lost production, asset integrity, and well-intervention campaigns. The complete paper highlights solids-management technologies that are currently available and still in use topside (and some of which are potentially outdated). It also identifies the amount of exposure to hazardous byproducts of produced oil and gas from these various technologies.

The complete paper also presents a new-technology case study and compares this with legacy methods and practices in terms of health, safety, and environment (HSE) risk and cost.

Naturally Occurring Radioactive Materials (NORM)

NORM can be divided into sources that originate from the ground and those produced from the interaction of atmospheric gases with cosmic rays. The risks associated with NORM, and the solutions available to manage those risks, are not widely known in the industry. The complete paper focuses on 3 NORM, which originate from the ground. The paper further details the characteristics of benzene and hydrogen sulfide, two other hazardous materials often encountered in solids-handling within the industry.

NORM Hazards. - The hazardous elements found in NORM are radionuclides such as radium 226 and 228, radon 222, and daughter products from these radionuclides. The concentration of radium and other daughter products builds up in the body over time. The elements can migrate to bone tissue and concentrate, causing bone cancers, lymphoma, leukemia, and other serious medical conditions. Employers should always prioritize minimization of exposure of their offshore personnel.

NORM in the Oil and Gas Industry. - Scale may build up over time from naturally occurring radium and its daughter products in wellbores, pipes, and vessels. Isotopes build and radiate differently depending on the reservoir rock and salinity of the well. Because a correlation usually exists between the age of a well and salinity (which increases with age), old wells seem to carry higher NORM levels than younger wells.
Psychological Factors Coupled With Machine Learning Improve Rig Training
Authors: Carpenter Chris
Published: September 2022

This article, written by JPT Technology Editor Chris Carpenter, contains highlights of paper SPE 208689, “Coupling Psychological Factors With Machine Learning To Improve Rig Technical Training,” by Francesco Curina, Elia Abdo, and Ajith Asokan, Drillmec, et al. The paper has not been peer reviewed.

The complete paper explains how machine learning and physiology can be used to improve rig technical training by monitoring the operator’s stress, identifying key operations in which situational awareness is low, and targeting these operations with dedicated exercises. The developed methodology is based on a study of human psychological indicators captured through light biometric devices. These indicators are fed to a machine-learning algorithm that calculates a stress index for the observed operator. The model uses machine vision to identify key physiological parameters and a convolutional neural network to interpret them. Finally, a third algorithm correlates the stress index to specific operations.

Introduction

In recent years, with the advent of machine learning and accurate biometric sensing devices, many models have been produced to identify stress automatically and instantaneously. Support-vector-machine and random forest models have shown special affinity for these applications. As for biometric sensing devices, they currently are found in most wearables and are available for relatively low prices. Most notably, electrocardiogram (ECG), electroencephalogram, and photoplethysmograph sensors, in addition to thermal cameras, are the most-used types.

In drilling operations, a driller may be aware of emergency procedures but the actual event itself will stress them acutely. In addition, continuous changes introduced to the layout or technology of the human/machine interface (HMI) can be a source of stress even for an experienced driller. Thus, identification of the stressful scenario for a specific driller and training them for that task while using the same HMI as the actual rig would enable the operator to stay alert and responsive during a real emergency on the rig.

Many emergency situations may occur during drilling operations that may lead to high-risk situations. However, none can be considered a higher risk than a well-control situation. Therefore, the focus of this study has been placed upon well-control situations and simulator training.
Performance Improvement for Optical OFDM Systems Using Symbol Time Compression
Authors: Ramadan Khaled , Elbakry Mohamed S.
Published: September 2022

Visible light communication (VLC) is now used to achieve high data rates. Optical-orthogonal frequency division multiplexing (O-OFDM) is a strong technique for intensity modulation and direct detection (IM-DD). Direct current biased O-OFDM (DCO-OFDM) and asymmetrically clipped O-OFDM are two modern O-OFDM systems that operate with IM-DD constraints (ACO-OFDM). Due to severe out of band interference, the DCO-OFDM and ACO-OFDM systems have a high peak to average power ratio (PAPR) and substantial adjacent channel interference (ACI) (OOB). Furthermore, as compared to bipolar OFDM systems, they obtain a greater chance of bit error. The combination of the STC scheme, symbol extension, and pulse shaping signal is presented in this paper for improving the performance of the O-OFDM system without affecting system throughput. This article also decreases the OOB, PAPR, and bit error rate (BER) of DCO-OFDM and ACO-OFDM systems. Further analytical analyses for the proposed systems, such as OOB, PAPR, and computing complexity, are obtained in this paper. The simulation results verify the analytical study of the proposed methods for OOB reduction and PAPR reduction. As compared to typical O-OFDM systems, the proposed shaped STC-DCO-OFDM scheme and the proposed shaped STC-ACO-OFDM scheme lower the OOB by about 40 dB and the PAPR by about 4 dB at the 10− 3 probability point of the complementary cumulative distribution function (CCDF). The proposed systems outperform existing O-OFDM systems under AWGN for the BPSK modulation scheme in terms of BER, and reduce the computational complexity.
TGFBI remodels adipose metabolism by regulating the Notch-1 signaling pathway
Authors: Nam Ju-Ock , Lee Seul Gi , Woo Seon Min , Seo Seung Un , Kim Ha-Jeong , Schlaepfer David D. , Kim In-San , Park Hee-Sae , Kwon Taeg Kyu
Published: September 2022

Extracellular matrix proteins are associated with metabolically healthy adipose tissue and regulate inflammation, fibrosis, angiogenesis, and subsequent metabolic deterioration. In this study, we demonstrated that transforming growth factor-beta (TGFBI), an extracellular matrix (ECM) component, plays an important role in adipose metabolism and browning during high-fat diet-induced obesity. TGFBI KO mice were resistant to adipose tissue hypertrophy, liver steatosis, and insulin resistance. Furthermore, adipose tissue from TGFBI KO mice presented a large population of CD11b+ macrophages, which control adipokine secretion through paracrine mechanisms. Mechanistically, we showed that inhibiting TGFBI-stimulated release of adipsin by Notch-1-dependent signaling resulted in adipocytes browning. TGFBI was physiologically bound to Notch-1 and stimulated its activation in adipocytes. Our findings revealed a novel protective effect of TGFBI deficiency in obesity that is realized via the activation of the Notch-1 signaling pathway.
Medical resources and medical activities affect the rate of home death in cancer patients: Analysis by prefecture using Japanese National Database and public data
Authors: Tarasawa Kunio , Fujimori Kenji , Ogata Tomoaki , Chiba Hiroki , Moriya Yukinori
Published: September 2022

Background: In Japan, over half of the population, about 55.0%, hope to die at home, while 73.0% of the actual deaths are in hospitals. In particular, the hospital death rate for cancer, which is the leading cause of death, is even higher at 82.4%, which is also high internationally. Therefore, there is an urgent need to establish conditions for fulfilling the hopes of patients who hope to die at home, especially cancer patients. The aim of this study is to clarify the actual situation of home death in Japanese cancer patients and the influential factors related
to home death.
Methods: We used the National Database and public data. Japan's Ministry of Health, Labor and Welfare provides applicants with national data (National Database), big data related to medical services for research purposes. Using the National Database, we calculated the rate of home death by prefecture. In addition, we collected medical resources information and medical activities information from public data to clarify home death factors. Finally, we conducted a multiple regression analysis to investigate the home death rate factors.
Results: During the study period from April 2017 to March 2018, we extracted 56,650 patients. We determined that the home death rate showed a specific difference by prefecture. There was a difference of about three times (14.3%-42.1%) between the maximum and minimum values. We also found that the activity of home-visit medical care by doctors is substantial as a factor to increase the rate of a home death (Standardized coefficient 0.586), and the number of acute care beds and the number of long-term care beds were significant factors to decrease the rate of home death (Standardized coefficient -0.334 and -0.220).
Conclusions: Based on these results, it is essential to improve home-visit medical care activities in order to increase the home death in the future. By enhancing the activities of home-visit medical care, it is desirable to improve home-based palliative care and establish a system that enables cancer patients who want to die at home to realize it.
Testing Framework for Big Data: A Case Study of Telecom Sector of Pakistan
Authors: Nasir Neelum , Imtiaz Salma , Imtiaz Saima , Nabeel Muhammad
Published: September 2022

Big Data has emerged as an asset for business practices and marketing strategies due to its data analysis capabilities. For an effective decision-making process, reliable data is critically important. Unreliable data results in wrong decision making ultimately leading to a negative reputation, customer churn, and financial loss. Therefore, testing Big Data is vital to ensure the reliability of data. Defining test strategies and setting up a testing environment are complex and challenging tasks. In this research, we tend to focus on data reliability, since a wrong decision based on unreliable data can have huge negative consequences. The testing framework for Big Data is validated via an exploratory case study in the telecommunication sector. Three-layer architecture for Big Data testing is used, namely Ingestion, Preparation, and Access. Errors are injected to verify fault injection in the ingestion and processing of data files of the Hadoop framework and technology stack. The results of the testing framework show errors in three layers of Big Data. The testing framework effectively detects data faults in Big Data,and a total of 76.92% errors in the presentation layer of total failed test cases are identified. 48.72% of test cases are developed to detect errors to check data accuracy, and after execution of these test cases 31.58% errors are detected. The highest proportion of errors detected are related to the completeness, which is 66.67% of the number of errors injected for completeness. The results show the effectiveness of the framework to identify accuracy and completeness errors.
Lactase Deficiency in Russia: Multiethnic Genetic Study
Authors: Kovalenko Elena , Vergasova Ekaterina , Shoshina Olesya , Popov Iaroslav , Ilinskaya Anna , Kim Anna , Plotnikov Nikolay , Barenbaum Isroel , Elmuratov Artem , Ilinsky Valery , Volokh Olesya , Rakitko Alexander
Published: September 2022

Background
Lactase persistence — the ability to digest lactose through adulthood — is closely related to evolutionary adaptations and has affected many populations since the beginning of cattle breeding. Nevertheless, the contrast initial phenotype, lactase non-persistence or adult lactase deficiency, is still affecting large numbers of people worldwide.
Methods
We performed the largest multiethnic genetic study of lactase deficiency on 24439 people in Russia to date. The percent of each population group was estimated according to the local ancestry inference results. Additionally, we calculated frequencies of rs4988235 GG genotype in Russian regions using the information of current location and birthplace data in client’s questionnaire.
Results
It turned out that among all studied population groups the frequency of GG genotype in rs4988235 was higher than in average in the European populations. In particular, the prevalence of lactase deficiency genotype in the East Slavs group was 42.8% (95% CI: 42.1–43.4%). We also investigated the regional prevalence of lactase deficiency by current place of residence.
Conclusions
Our study emphasizes the diagnostic significance of genetic testing, i.e. specifically for lactose intolerance parameter, as well as the scale of the problem of lactase deficiency in Russia which needs to be addressed by healthcare and food industry.
Midwife Empathy and Its Association with the Childbirth Experience: A Cross-Sectional Study
Authors: Jin Yuhua , Wu Yanpeng , Li Jing
Published: September 2022

Background
Although pregnancy and childbirth comprise a life-course that most midwives experience, whether their own experiences of childbirth resonate with other women during childbirth remains to be determined. In this study, we therefore characterized midwives’ empathic capabilities and defined their underlying factors.
Method
We conducted a cross-sectional study with data from 464 midwives in Guangdong, China, that were collected through the “Chinese version of the Jefferson Scale of Empathy for Health Professionals (JSE-HP).” This questionnaire contains sections related to midwife demographics and delivery characteristics. We then implemented multivariate logistic regression analysis to identify empathy-related factors.
Results
Our analysis revealed 303 (65.3%) participants in the high-empathy group while 161 (34.7%) were in the middle-empathy group. Compared with the reference groups, these results indicated that higher empathy was associated with an elevated educational level (OR, 1.83; 95% CI, 1.04–3.25), high monthly salary (OR, 2.30; 95% CI, 1.11–4.80), and no shift work (OR, 2.89; 95% CI, 1.09–7.63). The odds of a high empathy score were higher for midwives who experienced two childbirths (2.27, 1.11–4.66) and for those who had children under the age of three years (2.81, 1.34–5.92).
Conclusion
Midwives possess a moderate-to-high level of empathy, and the greater the number of childbirths they experienced and the younger their children, the higher their reported empathy score. This study contributes novel information regarding the empathic behavior of midwives toward women who give birth in China.
Barriers to prophylaxis treatment among haemophilia A patients and caregivers in Shandong Province, China: a descriptive qualitative study
Authors: Liu Ziyu , Feng Junchao , Fang Yunhai , Yan Cheng , Li Shunping
Published: September 2022

Background: As one of the most common rare diseases, haemophilia A poses a great burden to human society. Prophylaxis treatment is considered optimal for patients to prevent uncontrolled bleeding and reduce severity of injury. However, little is known about the use of prophylaxis treatment among haemophilia A patients in China, especially barriers that predispose them to low or non-adherence.
Objective: In this study, we explored barriers that were experienced or perceived by haemophilia A patients and their caregivers who have initiated prophylaxis treatment in Shandong province in China.
Methods: Primarily inspired by the AAAQ framework, we conducted 19 one-to-one interviews and 3 focus groups (18 interviewees in total). Data were analysed using a descriptive phenomenology approach and further discussed through inductive analysis.
Results: Results revealed that haemophilia A patients and their caregivers struggled with nine intertwined barriers, including lack of health services for early diagnosis; inadequate supportive services for prophylaxis treatment in primary care; difficulties to obtain FⅧ concentrate at locals; financial concern associated with prophylaxis treatment; insufficient information regarding self-infusion and disease management; lack of a clarified role of primary care nurses as an acceptable care provider for infusing FVIII concentrate; lack of trust for newly developed techniques of infusion except gene therapy; safety concern associated with different product types; and poor user experience of domestic-produced infusion devices. Resulted from an inductive analysis, three clusters of underlying causes of barriers were observed: poor primary health care, inadequate social support, and failed to be patient-centred, which meanwhile highlighted opportunities for service providers and policy makers to better target and proactively design interventions towards improving prophylaxis treatment adherence in patients with haemophilia A.
Conclusions: Although this study was conducted in the Chinese context, the findings still could serve as a good reference for other nations when actions are needed to protect patients affected by rare diseases.
Efficacy and safety of double balloon catheter and dinoprostone for labor induction in multipara at term
Authors: yuan lu , Peng Jing , Yang Lijun , Zhao Yun
Published: September 2022

Purpose
The aim of this study was to comparatively assess the efficacy and safety of double balloon catheter (DBC) and dinoprostone as labor-inducing agents just for multipara at term.
Methods
A retrospective cohort study was conducted among multipara at term with a Bishop score < 6 who needed planned labor induction from January 1, 2020, to December 30, 2020 in Maternal and Child Health Hospital of Hubei province, Tongji Medical College, Huazhong University of Science and Technology. They were divided into DBC group and dinoprostone group respectively. Baseline maternal data, maternal and neonatal outcomes were recorded for statistical analysis. Total vaginal delivery rate, rate of vaginal delivery within 24 h, rate of uterine hyperstimulation combined with abnormal fetal heart rate(FHR) were regarded as the primary outcome variables. The diffrerence between groups was considered statistically significant when p value < 0.05.
Results
A total of 202 multipara was included for analysis (95 women in DBC group vs 107 women in dinoprostone group). There were no significant differences in total vaginal delivery rate and rate of vaginal delivery within 24 h between groups. Uterine hyperstimulation combined with abnormal FHR occurred exclusively in dinoprostone group.
Conclusion
DBC and dinoprostone seem to be equally effective, and DBC seems to be safer than dinoprostone as it causes lower rate of uterine hyperstimulation combined with abnormal FHR.
A Safety and Efficacy Comparison of polyethylene glycol, hemp seed oil, and 5% sugar brine for bowel preparation in older adults patients: study protocol for a randomized controlled trial
Authors: zhu xing wang , Yan Jun , Miao Long , He Ying Li , Wang Hai Ping , Li Xun
Published: September 2022

Background: The incidence of colorectal cancer among the middle-aged and elderly is gradually increasing in China. Colonoscopy is an effective method for early diagnosis of colorectal cancer, and bowel preparation is one of many important factors affecting colonoscopy. Although there are many studies on intestinal cleansers, the results are not ideal. There is evidence that hemp seed oil has certain potential effects in intestinal cleansing, but prospective studies in this area are still lacking.
Methods: This is a randomized, double-blind, single-center clinical study. We randomly assigned 690 subjects to a combination of 3L PEG; 30 mL hemp seed oil and 2L PEG; or 30 mL hempseed oil, 2L PEG, and 1000 ml 5% sugar brine.
Boston Bowel Preparation Scale (BBPS) was considered the primary outcome measure. We evaluated the interval between consumption of the bowel preparation and the first bowel movement. Secondary indicators were evaluated after the total number of bowel movements; these included the time of cecal intubation, the detection rate of polyps and adenomas, the willingness to repeat the same bowel preparation, whether the protocol is tolerated, and whether there were adverse reactions during bowel preparation.
Discussion: This study aimed to test the hypotheses that hemp seed oil (30 ml) increases the quality of bowel preparation while reducing the amount of polyethylene glycol (PEG), and its combination with 5% sugar saline can reduce the occurrence of adverse reactions.
Trial registration: The study was prospectively registered on March 15, 2022, Chinese Clinical Trial Registry (www.chictr.org.cn, ChiCTR2200057626); Pre-results.
Floquet engineering of tilted and gapped Dirac band structures in 1T'-MoS2
Authors: Iurov Andrii , Zhemchuzhna Liubov , Gumbs Godfrey , Huang Danhong , Tse Wang-Kong , Blaise Kathy , Ejiogu Chinedu
Published: September 2022

We have developed a rigorous theoretical formalism for Floquet engineering, investigating, and subsequently tailoring most crucial electronic properties of 1T'-MoS2 by applying an external high-frequency dressing field within the off-resonance regime. It was recently demonstrated that monolayer semiconducting 1T'-MoS2 exhibits tunable and gapped spin- and valley-polarized tilted Dirac bands. The electron-photon dressed states depend strongly on the polarization of the applied irradiation and reflect a full complexity of the low-energy Hamiltonian for non-irradiated material. We have calculated and analyzed the properties of the electron dressed states corresponding to linear and circular polarization of a dressing field by focusing on their symmetry, anisotropy, tilting, direct and indirect band gaps. Circularly polarized dressing field is known for transition into a new electronic state with broken time-reversal symmetry and a non-zero Chern number, and therefore, the combination of these topologically non-trivial phases and transitions between them could reveal some truly unique and previously unknown phenomena and applications. We have also computed and discussed the density of states for various types of 1T'-MoS2 materials and its modification in the presence of a dressing field.
Parathyroid hormone related peptide levels may be related to obesity: a novel target for treatment?
Authors: ozturk gokmen , Ersavas Cenk
Published: September 2022

Obesity, has become a significant public health issue in the last two decades In recent years, several studies have suggested that adipose tissue homeostasis is vital in developing obesity. The production of excessive pro-inflammatory adipokines and inflammatory chemokines by dysfunctional adipocytes contributes to chronic inflammation and ultimately leads to systemic metabolic problems
The Parathyroid Hormone-Related Protein (PTHrP), a member of a small gene family associated with parathyroid hormone was shown to increase cachexia by browning white adipose tissue. Along with the role of brown adipose tissue in obesity prevention, PTHrP may have a role in the etiology of obesity. This study aims to evaluate the probable relationship between obesity, PTHrp, and inflammation.
Material and methods
Patients who were admitted to hospital for bariatric surgery were included in this cross-sectional study. For biochemical tests the venous blood of patients fasted for 12-14 h was taken in the morning. PTHrP elisa kit: Human Parathyroid Hormone Related Protein ELISA Kit (Cat.No: MBS017831).used for PTHrP measurements following the manufacturer’s instructions.
Results
A total of 550 patients were recruited for the study, of which 145(26.4%) were males. mean BMI was 40.88±5.85 kg/m2 and mean PTHrP was 35.43±12.83. The patient group was grouped in terms of BMI (Group 1= BMI<40 and Group 2 =BMI≥40). CRP was significantly higher in group 2(4.8±3.3 vs 4.1±2.9; P=0.004) while PTHRP was significantly lower in (36.19±11.87vs. 36.896±13.577; P=0.005). ın correlation analysis BMI was found to be positively correlated with CRP(R=0.341, P=0.00), blood glucose(R=0.091, P=0.034) and negatively correlated with PTHRP(R=-0.134, P=0.002). ın linear regression, PTHrP, CRP and blood glucose were major determinants of BMI
Conclusion
A lower BMI was associated with a higher PTHrP level. PTHrP, may cause a transformation from brown to white adipose tissue. Therefore, PTHrP might be a novel treatment for overweight persons.
Exploring the Potential of Intranasally Administered Naturally Occurring Quercetin Loaded into Polymeric Nanocapsules as a Novel Platform for the Treatment of Anxiety
Authors: Mahmoud Khaled Y. , Elhesaisy Nahla A. , Rashed Abdelrahman R. , Mikhael Ebram S. , Fadl Mahmoud I. , Elsadek Mahmoud S. , Mohamed Merna A. , Mostafa Merna A. , Hassan Mohamed A. , Halema Omar M. , Elnemer Youssef H. , Swidan Shady A.
Published: September 2022

Anxiety is one of the most prevalent forms of psychopathology that affects millions worldwide. It gains more importance under the current pandemic status that resulted in higher anxiety prevalence. Anxiolytic drugs such as benzodiazepines have an unfavorable risk/benefit ratio resulting in a shift toward active ingredients with better safety profile such as the naturally occurring quercetin. The delivery of quercetin is hampered by its low water solubility and low bioavailability. The potential of enhancing quercetin delivery to the brain utilizing polymeric nanocapsules administered nasally is investigated in the current study. Polymeric nanocapsules were prepared utilizing the nanoprecipitation technique. The best formula displayed a particle size of 227.8 ± 11.9, Polydispersity index of 0.466 ± 0.023, zeta potential of -17.5 ± 0.01, and encapsulation efficiency % of 92.5 ± 1.9. The prepared nanoparticles displayed In vitro release of QRC loaded polymeric nanocapsules exhibited a biphasic release with an initial burst release followed by a sustained release pattern. The in vivo evaluation demonstrated the superiority of quercetin polymeric nanocapsules administered intranasally compared quercetin dispersion administered both orally and intranasally. The prepared nanocapsules also demonstrated good safety profile with high tolerability.