bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Table 2B from Nrf2 Prevents Initiation but Accelerates Progression through the Kras Signaling Pathway during Lung Carcinogenesis
Authors: Satoh Hironori , Moriguchi Takashi , Takai Jun , Ebina Masahito , Yamamoto Masayuki
Published: March 2023

PDF file - 30K, High expression genes involved only in lung tumor of Nrf2-/- mice.
Supplementary Table 1 from PGC-1α Promotes the Growth of ErbB2/Neu–Induced Mammary Tumors by Regulating Nutrient Supply
Authors: Klimcakova Eva , Chénard Valérie , McGuirk Shawn , Germain David , Avizonis Daina , Muller William J. , St-Pierre Julie
Published: March 2023

PDF file - 62K
Supplementary Table 2A from Nrf2 Prevents Initiation but Accelerates Progression through the Kras Signaling Pathway during Lung Carcinogenesis
Authors: Satoh Hironori , Moriguchi Takashi , Takai Jun , Ebina Masahito , Yamamoto Masayuki
Published: March 2023

PDF file - 26K, High expression genes only in lung tumor of Nrf2+/+ mice.
Supplementary Table 1 from Nrf2 Prevents Initiation but Accelerates Progression through the Kras Signaling Pathway during Lung Carcinogenesis
Authors: Satoh Hironori , Moriguchi Takashi , Takai Jun , Ebina Masahito , Yamamoto Masayuki
Published: March 2023

PDF file - 93K, Primers for PCR and RT-PCR experiments.
Supplementary Figure 1 from PGC-1α Promotes the Growth of ErbB2/Neu–Induced Mammary Tumors by Regulating Nutrient Supply
Authors: Klimcakova Eva , Chénard Valérie , McGuirk Shawn , Germain David , Avizonis Daina , Muller William J. , St-Pierre Julie
Published: March 2023

PDF file - 54K
Supplementary Figure Legend from A Preclinical Mouse Model of Invasive Lobular Breast Cancer Metastasis
Authors: Doornebal Chris W. , Klarenbeek Sjoerd , Braumuller Tanya M. , Klijn Christiaan N. , Ciampricotti Metamia , Hau Cheei-Sing , Hollmann Markus W. , Jonkers Jos , de Visser Karin E.
Published: March 2023

PDF file - 33K
Supplementary Methods, Tables 1-2 from DDX31 Regulates the p53-HDM2 Pathway and rRNA Gene Transcription through Its Interaction with NPM1 in Renal Cell Carcinomas
Authors: Fukawa Tomoya , Ono Masaya , Matsuo Taisuke , Uehara Hisanori , Miki Tsuneharu , Nakamura Yusuke , Kanayama Hiro-omi , Katagiri Toyomasa
Published: March 2023

PDF file - 219K
Supplementary Figure 2 from DDX31 Regulates the p53-HDM2 Pathway and rRNA Gene Transcription through Its Interaction with NPM1 in Renal Cell Carcinomas
Authors: Fukawa Tomoya , Ono Masaya , Matsuo Taisuke , Uehara Hisanori , Miki Tsuneharu , Nakamura Yusuke , Kanayama Hiro-omi , Katagiri Toyomasa
Published: March 2023

PDF file - 1.5MB, (A) Effects of siRNA-mediated NPM1 knockdown on DDX31 localization in the RCC cell line, Caki-1. NPM1 knockdown did not affect DDX31 nucleolar localization. (B) Effects of DDX31 knockdown on Nucleolin localization. Nucleolin localization was not affected by the presence or the absence of DDX31. Scale bar shows 50 mum
Supplementary Figure S1 from Regulation of FANCD2 by the mTOR Pathway Contributes to the Resistance of Cancer Cells to DNA Double-Strand Breaks
Authors: Shen Changxian , Oswald Duane , Phelps Doris , Cam Hakan , Pelloski Christopher E. , Pang Qishen , Houghton Peter J.
Published: March 2023

Supplementary Figure S1 - PDF file 2155K, The mTOR Pathway Regulates FANCD2. A, Rh30 cells were exposed to AZD8055 (2 �M) for the times indicated and total proteins were extracted for immunoblotting to detect FANCD2. B, Rh30 cells were transfected with vector, AKT1-Myc plasmid encoding wild type AKT1. 48 hr later, total proteins were extracted for detection of FANCD2, GSK3�, pGSK3�-S9, AKT and pAKT-S473. Myc antibody was used to show the expression of AKT1 wt with Myc tag. C, Rh30 cells were transfected with vector, Myr-AKT1 plasmid encoding constitutively active AKT1. 48 hr later, total proteins were extracted for detection of FANCD2, GSK3�, pGSK3�-S9, AKT and pAKT-S473. D, Rh30 cells were treated with rapamycin (100 ng/mL), AZD8055 (2 �M) or MK2206 (10 �M) for 16 hr. Total proteins were extracted for immunoblotting of FANCD2, S6K1, pS6K1-T389, AKT and pAKT-S473. GAPDH and �-Actin served as loading control
Supplementary Figure Legend from Pancreatic Cancer-Associated Stellate Cells Promote Differentiation of Myeloid-Derived Suppressor Cells in a STAT3-Dependent Manner
Authors: Mace Thomas A. , Ameen Zeenath , Collins Amy , Wojcik Sylwia , Mair Markus , Young Gregory S. , Fuchs James R. , Eubank Tim D. , Frankel Wendy L. , Bekaii-Saab Tanios , Bloomston Mark , Lesinski Gregory B.
Published: March 2023

PDF file - 55K
Supplementary Figure 1 from Pancreatic Cancer-Associated Stellate Cells Promote Differentiation of Myeloid-Derived Suppressor Cells in a STAT3-Dependent Manner
Authors: Mace Thomas A. , Ameen Zeenath , Collins Amy , Wojcik Sylwia , Mair Markus , Young Gregory S. , Fuchs James R. , Eubank Tim D. , Frankel Wendy L. , Bekaii-Saab Tanios , Bloomston Mark , Lesinski Gregory B.
Published: March 2023

PDF file - 793K, Supplementary Figure S1. PSC secrete variable or undetectable levels of PGE2.
Supplementary Table 3 from RhoJ Regulates Melanoma Chemoresistance by Suppressing Pathways That Sense DNA Damage
Authors: Ho Hsiang , Aruri Jayavani , Kapadia Rubina , Mehr Hootan , White Michael A. , Ganesan Anand K.
Published: March 2023

XLS file - 16MB, Microarray Dataset. mRNA expression profiles of SK-MEL-28 cells expressing control or RhoJ shRNAs were compared. Significantly upregulated or downregulated genes are indicated (p<.005).
Supplementary Table 2 from RhoJ Regulates Melanoma Chemoresistance by Suppressing Pathways That Sense DNA Damage
Authors: Ho Hsiang , Aruri Jayavani , Kapadia Rubina , Mehr Hootan , White Michael A. , Ganesan Anand K.
Published: March 2023

PDF file - 1MB, RhoJ is upregulated in advanced tumors. RhoJ gene expression was compared between 16 primary and 40 metastatic flash-frozen melanoma tumors.
Supplementary Table 6 from Cross-Species Functional Analysis of Cancer-Associated Fibroblasts Identifies a Critical Role for CLCF1 and IL-6 in Non–Small Cell Lung Cancer In Vivo
Authors: Vicent Silvestre , Sayles Leanne C. , Vaka Dedeepya , Khatri Purvesh , Gevaert Olivier , Chen Ron , Zheng Yanyan , Gillespie Anna K. , Clarke Nicole , Xu Yue , Shrager Joseph , Hoang Chuong D. , Plevritis Sylvia , Butte Atul J. , Sweet-Cordero E. Alejandro
Published: March 2023

XLS file - 27K, Meta-Analysis of 5 human data sets incorporating array expression data
Supplementary Table 5 from Cross-Species Functional Analysis of Cancer-Associated Fibroblasts Identifies a Critical Role for CLCF1 and IL-6 in Non–Small Cell Lung Cancer In Vivo
Authors: Vicent Silvestre , Sayles Leanne C. , Vaka Dedeepya , Khatri Purvesh , Gevaert Olivier , Chen Ron , Zheng Yanyan , Gillespie Anna K. , Clarke Nicole , Xu Yue , Shrager Joseph , Hoang Chuong D. , Plevritis Sylvia , Butte Atul J. , Sweet-Cordero E. Alejandro
Published: March 2023

XLS file - 21K, Ingenuity Pathway Analysis for Functional Networks
Supplementary Figure 6 from RhoJ Regulates Melanoma Chemoresistance by Suppressing Pathways That Sense DNA Damage
Authors: Ho Hsiang , Aruri Jayavani , Kapadia Rubina , Mehr Hootan , White Michael A. , Ganesan Anand K.
Published: March 2023

PDF file - 156K, RhoJ Regulates the Expression of Sox10. A. RhoJ Regulates the Expression of Genes that Control Neural Differentiation.
Supplementary Figure 5 from RhoJ Regulates Melanoma Chemoresistance by Suppressing Pathways That Sense DNA Damage
Authors: Ho Hsiang , Aruri Jayavani , Kapadia Rubina , Mehr Hootan , White Michael A. , Ganesan Anand K.
Published: March 2023

PDF file - 184K, RhoJ Uncouples ATR From Chk1. A. RhoJ does not inhibit the DNA damage foci formation.
Supplementary Figure 4 from RhoJ Regulates Melanoma Chemoresistance by Suppressing Pathways That Sense DNA Damage
Authors: Ho Hsiang , Aruri Jayavani , Kapadia Rubina , Mehr Hootan , White Michael A. , Ganesan Anand K.
Published: March 2023

PDF file - 149K, siRNAs inhibit the expression of their cognate targets
Supplementary Methods from Cross-Species Functional Analysis of Cancer-Associated Fibroblasts Identifies a Critical Role for CLCF1 and IL-6 in Non–Small Cell Lung Cancer In Vivo
Authors: Vicent Silvestre , Sayles Leanne C. , Vaka Dedeepya , Khatri Purvesh , Gevaert Olivier , Chen Ron , Zheng Yanyan , Gillespie Anna K. , Clarke Nicole , Xu Yue , Shrager Joseph , Hoang Chuong D. , Plevritis Sylvia , Butte Atul J. , Sweet-Cordero E. Alejandro
Published: March 2023

PDF file - 85K
Supplementary Figure 6 from Cross-Species Functional Analysis of Cancer-Associated Fibroblasts Identifies a Critical Role for CLCF1 and IL-6 in Non–Small Cell Lung Cancer In Vivo
Authors: Vicent Silvestre , Sayles Leanne C. , Vaka Dedeepya , Khatri Purvesh , Gevaert Olivier , Chen Ron , Zheng Yanyan , Gillespie Anna K. , Clarke Nicole , Xu Yue , Shrager Joseph , Hoang Chuong D. , Plevritis Sylvia , Butte Atul J. , Sweet-Cordero E. Alejandro
Published: March 2023

PDF file - 19K, Decrease response to CAF-derived clcf1 in cntfr-depleted tumor cells
Supplementary Figure 5 from Cross-Species Functional Analysis of Cancer-Associated Fibroblasts Identifies a Critical Role for CLCF1 and IL-6 in Non–Small Cell Lung Cancer In Vivo
Authors: Vicent Silvestre , Sayles Leanne C. , Vaka Dedeepya , Khatri Purvesh , Gevaert Olivier , Chen Ron , Zheng Yanyan , Gillespie Anna K. , Clarke Nicole , Xu Yue , Shrager Joseph , Hoang Chuong D. , Plevritis Sylvia , Butte Atul J. , Sweet-Cordero E. Alejandro
Published: March 2023

PDF file - 46K, Clcf1- and il6-expressing NFs enhance tumor growth in vivo
Supplementary Tables 1-4 from Genomic Profiling of Isolated Circulating Tumor Cells from Metastatic Breast Cancer Patients
Authors: Magbanua Mark Jesus M. , Sosa Eduardo V. , Roy Ritu , Eisenbud Lauren E. , Scott Janet H. , Olshen Adam , Pinkel Dan , Rugo Hope S. , Park John W.
Published: March 2023

PDF file - 127K, TABLE S1: List of patients and circulating tumor cells (CTCs) samples; TABLE S2: Comparison of immunomagnetic enrichment/fluorescence activated cell sorting (IE/FACS) versus CellSearch; TABLE S3: Copy number alterations at the arm level in circulating tumor cells (CTCs) from and their matched primary tumor (PT) and/or lymph node (LN) tissues; TABLE S4: Genomic aberrations in CTCs vs. primary tumors
Supplementary Figure Legends 1-8, Table Legends 1-4 from Genomic Profiling of Isolated Circulating Tumor Cells from Metastatic Breast Cancer Patients
Authors: Magbanua Mark Jesus M. , Sosa Eduardo V. , Roy Ritu , Eisenbud Lauren E. , Scott Janet H. , Olshen Adam , Pinkel Dan , Rugo Hope S. , Park John W.
Published: March 2023

PDF file - 85K
Supplementary Figure 4 from PD-1 Blockade Enhances T-cell Migration to Tumors by Elevating IFN-γ Inducible Chemokines
Authors: Peng Weiyi , Liu Chengwen , Xu Chunyu , Lou Yanyan , Chen Jieqing , Yang Yan , Yagita Hideo , Overwijk Willem W. , Lizée Gregory , Radvanyi Laszlo , Hwu Patrick
Published: March 2023

PDF file - 31K, Change in frequency of CXCL10-production cells and transferred pmel-1 T cells within spleen from mice receiving ACT in response to anti-PD-1 treatment
Supplementary Video 2 from The Melanoma‐Upregulated Long Noncoding RNA SPRY4-IT1 Modulates Apoptosis and Invasion
Authors: Khaitan Divya , Dinger Marcel E. , Mazar Joseph , Crawford Joanna , Smith Martin A. , Mattick John S. , Perera Ranjan J.
Published: March 2023

Supplementary Video 2 from The Melanoma‐Upregulated Long Noncoding RNA SPRY4-IT1 Modulates Apoptosis and Invasion
Supplementary Figure 3 from PD-1 Blockade Enhances T-cell Migration to Tumors by Elevating IFN-γ Inducible Chemokines
Authors: Peng Weiyi , Liu Chengwen , Xu Chunyu , Lou Yanyan , Chen Jieqing , Yang Yan , Yagita Hideo , Overwijk Willem W. , Lizée Gregory , Radvanyi Laszlo , Hwu Patrick
Published: March 2023

PDF file - 37K, Representative contour plots of F4/80 and Ly6C expression in CXCL10-production CD11b+ cells within tumor tissue from mice treated with ACT and anti-PD-1
Supplementary Figure 2 from PD-1 Blockade Enhances T-cell Migration to Tumors by Elevating IFN-γ Inducible Chemokines
Authors: Peng Weiyi , Liu Chengwen , Xu Chunyu , Lou Yanyan , Chen Jieqing , Yang Yan , Yagita Hideo , Overwijk Willem W. , Lizée Gregory , Radvanyi Laszlo , Hwu Patrick
Published: March 2023

PDF file - 33K, Change in frequency of Treg and MDSCs within tumors from mice receiving ACT in response to PD-1 blockade
Supplementary Figures 6-10 from The Melanoma‐Upregulated Long Noncoding RNA SPRY4-IT1 Modulates Apoptosis and Invasion
Authors: Khaitan Divya , Dinger Marcel E. , Mazar Joseph , Crawford Joanna , Smith Martin A. , Mattick John S. , Perera Ranjan J.
Published: March 2023

Supplementary Figures 6-10 from The Melanoma‐Upregulated Long Noncoding RNA SPRY4-IT1 Modulates Apoptosis and Invasion
Supplementary Figures 8-11 from Antioxidant Enzymes Mediate Survival of Breast Cancer Cells Deprived of Extracellular Matrix
Authors: Davison Calli A. , Durbin Sienna M. , Thau Matthew R. , Zellmer Victoria R. , Chapman Sarah E. , Diener Justin , Wathen Connor , Leevy W. Matthew , Schafer Zachary T.
Published: March 2023

Catalase elimination in MDA-MB-231 cells does not alter glucose uptake activity, Catalase elimination in MDA-MB-231cells does not alter cell proliferation, Catalase deficiency in MDA-MB-231 cells has no bearing on cell viability, Catalase deficiency in T47D cells does not affect glucose uptake.
Supplementary Figures 16-19 from Antioxidant Enzymes Mediate Survival of Breast Cancer Cells Deprived of Extracellular Matrix
Authors: Davison Calli A. , Durbin Sienna M. , Thau Matthew R. , Zellmer Victoria R. , Chapman Sarah E. , Diener Justin , Wathen Connor , Leevy W. Matthew , Schafer Zachary T.
Published: March 2023

SOD2 deficiency in T47D cells has a negligible impact on cell viability, SOD1 deficiency in T47D cells diminishes ATP levels in ECM-detached cells, Nrf2 deficiency in T47D cells diminishes ATP levels in ECM-detached cells, SOD2 deficiency in ErbB2 positive SKBR3 cells leads to a decrease in ATP levels during ECM-detachment.
Supplementary Figures 12-15 from Antioxidant Enzymes Mediate Survival of Breast Cancer Cells Deprived of Extracellular Matrix
Authors: Davison Calli A. , Durbin Sienna M. , Thau Matthew R. , Zellmer Victoria R. , Chapman Sarah E. , Diener Justin , Wathen Connor , Leevy W. Matthew , Schafer Zachary T.
Published: March 2023

Catalase deficiency in T47D cells does not impact cell proliferation, Catalase deficiency in T47D cells does not impact cell viability, Diminished SOD2 expression in T47D cells has no on glucose uptake, SOD2 deficiency in T47D cells does not impact cell proliferation.
Supplementary Figures 1-4 from Antioxidant Enzymes Mediate Survival of Breast Cancer Cells Deprived of Extracellular Matrix
Authors: Davison Calli A. , Durbin Sienna M. , Thau Matthew R. , Zellmer Victoria R. , Chapman Sarah E. , Diener Justin , Wathen Connor , Leevy W. Matthew , Schafer Zachary T.
Published: March 2023

Antioxidant compound treatment does not affect glucose uptake in detached MCF-10A cells, Antioxidant compound treatment does not alter cell viability in attached E7/Bcl2 cells, Antioxidant compound treatment can be reversible, Catalase expression has no impact on glucose uptake in ECM-detached MCF-10A cells.
Supplementary Figure 2 from BMK1 Kinase Suppresses Epithelial–Mesenchymal Transition through the Akt/GSK3β Signaling Pathway
Authors: Chen Runqiang , Yang Qingkai , Lee Jiing-Dwan
Published: March 2023

PDF file - 240K
Supplementary Figure 1 from BMK1 Kinase Suppresses Epithelial–Mesenchymal Transition through the Akt/GSK3β Signaling Pathway
Authors: Chen Runqiang , Yang Qingkai , Lee Jiing-Dwan
Published: March 2023

PDF file - 226K
Supplementary Tables 1 - 3 from Oncogenic NRAS, Required for Pathogenesis of Embryonic Rhabdomyosarcoma, Relies upon the HMGA2–IGF2BP2 Pathway
Authors: Li Zhizhong , Zhang Yunyu , Ramanujan Krishnan , Ma Yan , Kirsch David G. , Glass David J.
Published: March 2023

PDF file - 36K, List of top 100 genes down-regulated and top 100 genes up-regulated by HMGA2 shRNA in the RD rhabdomyosarcoma cell line (S1); List of Top 100 mRNAs bound by IGF2BP2 in the human 293 cell line (S2); List of GEO Databases used to analyze the expression of HMGA2 and HMGA1 mRNA levels in normal tissues (S3).
Supplementary Figure Legends 1-4 from eIF4E/4E-BP Ratio Predicts the Efficacy of mTOR Targeted Therapies
Authors: Alain Tommy , Morita Masahiro , Fonseca Bruno D. , Yanagiya Akiko , Siddiqui Nadeem , Bhat Mamatha , Zammit Domenick , Marcus Victoria , Metrakos Peter , Voyer Lucie-Anne , Gandin Valentina , Liu Yi , Topisirovic Ivan , Sonenberg Nahum
Published: March 2023

PDF file - 101K
Supplementary Figure 1 from Neogenesis of Lymphoid Structures and Antibody Responses Occur in Human Melanoma Metastases
Authors: Cipponi Arcadi , Mercier Marjorie , Seremet Teofila , Baurain Jean-François , Théate Ivan , van den Oord Joost , Stas Marguerite , Boon Thierry , Coulie Pierre G. , van Baren Nicolas
Published: March 2023

PDF file - 418K, Immunohistological detection of the indicated antigens in adjacent cryosections of cutaneous melanoma metastasis T9
Supplementary Figure 4 from eIF4E/4E-BP Ratio Predicts the Efficacy of mTOR Targeted Therapies
Authors: Alain Tommy , Morita Masahiro , Fonseca Bruno D. , Yanagiya Akiko , Siddiqui Nadeem , Bhat Mamatha , Zammit Domenick , Marcus Victoria , Metrakos Peter , Voyer Lucie-Anne , Gandin Valentina , Liu Yi , Topisirovic Ivan , Sonenberg Nahum
Published: March 2023

PDF file - 2.3MB, Figure S4 contains data that show that the eIF4E/4E-BP ratio influences the antiproliferative efficacy of asTORi.
Supplementary Tables 1-8 from Loss of SNAIL Regulated miR-128-2 on Chromosome 3p22.3 Targets Multiple Stem Cell Factors to Promote Transformation of Mammary Epithelial Cells
Authors: Qian PengXu , Banerjee Arindam , Wu Zheng-Sheng , Zhang Xiao , Wang Hong , Pandey Vijay , Zhang Wei-Jie , Lv Xue-Fei , Tan Sheng , Lobie Peter E. , Zhu Tao
Published: March 2023

PDF file - 226K, TABLE S1: List of miRNAs on human chromosome 3p and the changes of their genome copies determined by genomic real-time PCR; TABLE S2: Clinical significance of the expression of miR-128 in breast cancer patients; TABLE S3: Invariable analysis of clinical outcome according to the expression of miR-128 in breast cancer patients (85 cases); TABLE S4: List of mRNAs predicted to be targeted by miR-128 by all the three programs: MiRanda, Pictar and TargetScan; TABLE S5: qRT-PCR analysis of the effect of forced expression of miR-128 in MDA-MB-231 cells or depleted expression of miR-128 in MCF-10A cells on mRNA levels of several key genes functionally involved in oncogenicity and neoplastic progression; TABLE S6: Sequences of the oligonucleotides for miRNAs, siRNAs, construct-making and ChIP assays; TABLE S7: Sequence of the oligonucleotides for real-time PCR experiments; TABLE S8: List of proteins tested by antibodies and characteristics of the corresponding antibodies used
Supplementary Materials and Methods from Loss of SNAIL Regulated miR-128-2 on Chromosome 3p22.3 Targets Multiple Stem Cell Factors to Promote Transformation of Mammary Epithelial Cells
Authors: Qian PengXu , Banerjee Arindam , Wu Zheng-Sheng , Zhang Xiao , Wang Hong , Pandey Vijay , Zhang Wei-Jie , Lv Xue-Fei , Tan Sheng , Lobie Peter E. , Zhu Tao
Published: March 2023

PDF file - 190K, Includes patient and specimen data, reagent information, miRNA and siRNA transfection, and statistical analysis. Also includes supplementary references
Supplementary Figure Legends 1-6 from Loss of SNAIL Regulated miR-128-2 on Chromosome 3p22.3 Targets Multiple Stem Cell Factors to Promote Transformation of Mammary Epithelial Cells
Authors: Qian PengXu , Banerjee Arindam , Wu Zheng-Sheng , Zhang Xiao , Wang Hong , Pandey Vijay , Zhang Wei-Jie , Lv Xue-Fei , Tan Sheng , Lobie Peter E. , Zhu Tao
Published: March 2023

PDF file - 205K
Supplementary Figure 4 from Epithelial-to-Mesenchymal Transition Induced by TGF-β1 Is Mediated by Blimp-1–Dependent Repression of BMP-5
Authors: Romagnoli Mathilde , Belguise Karine , Yu Ziyang , Wang Xiaobo , Landesman-Bollag Esther , Seldin David C. , Chalbos Dany , Barillé-Nion Sophie , Jézéquel Pascal , Seldin Margaret L. , Sonenshein Gail E.
Published: March 2023

PDF file - 222K, Erk1/2 and AP-1 activation is required for the induction of Blimp-1 in breast cancer cells
Supplementary Methods and Materials, Figure Legends and Supplementary Figures 1-10 from The V-ATPase-Inhibitor Archazolid Abrogates Tumor Metastasis via Inhibition of Endocytic Activation of the Rho-GTPase Rac1
Authors: Wiedmann Romina M. , von Schwarzenberg Karin , Palamidessi Andrea , Schreiner Laura , Kubisch Rebekka , Liebl Johanna , Schempp Christina , Trauner Dirk , Vereb Gyorgy , Zahler Stefan , Wagner Ernst , Müller Rolf , Scita Giorgio , Vollmar Angelika M.
Published: March 2023

PDF file 1545 K. Methods and Materials Cell culture, Scratch Assay/Immunfluorescence, siRNA transfection Fig. S1: Archazolid inhibits the acidification of lysosomes. Fig. S2: Archazolid inhibits cancer cell migration. Fig. S3: EGF-R and Her2 expression on the cell surface after archazolid treatment. Fig. S4: EGF-R plays a role in cell polarization. Fig.S5: The downregulation of the V-ATPase subunit c affects the cell migration process also in L3.6pl cells. Fig. S6: Rac1-GFP is less localized in Rab5-induced enlarged endosomes of archazolid treated cells. Fig. S7: Dissemination of 4T1-Luc breast cancer cells is decreased in archazolid A (1mg/kg) pretreated mice. Fig. S8: Scheme proposing the impact of V-ATPase inhibition on cell migration. Fig.S9: Beside the localization in lysosomes the V-ATPase is also localized at the plasma membrane. Fig. S10: Archazolid affects cellular recycling.
Supplementary Figure 6 from A Synthetic Matrix with Independently Tunable Biochemistry and Mechanical Properties to Study Epithelial Morphogenesis and EMT in a Lung Adenocarcinoma Model
Authors: Gill Bartley J. , Gibbons Don L. , Roudsari Laila C. , Saik Jennifer E. , Rizvi Zain H. , Roybal Jonathon D. , Kurie Jonathan M. , West Jennifer L.
Published: March 2023

PDF file - 35K, q-PCR data for several EMT markers shows that TGFbeta induces changes in expression of EMT-related genes in PEG-encapsulated 344SQ
Supplementary Methods and Figure Legend from MicroRNAs Regulate Tumor Angiogenesis Modulated by Endothelial Progenitor Cells
Authors: Plummer Prue N. , Freeman Ruth , Taft Ryan J. , Vider Jelena , Sax Michael , Umer Brittany A. , Gao Dingcheng , Johns Christopher , Mattick John S. , Wilton Stephen D. , Ferro Vito , McMillan Nigel A.J. , Swarbrick Alexander , Mittal Vivek , Mellick Albert S.
Published: March 2023

PDF file, 173K.
Supplementary Figures 1 - 7 from Gut Microbiota Protects against Gastrointestinal Tumorigenesis Caused by Epithelial Injury
Authors: Zhan Yu , Chen Po-Ju , Sadler William D. , Wang Fuyuan , Poe Sara , Núñez Gabriel , Eaton Kathryn A. , Chen Grace Y.
Published: March 2023

PDF file - 615K, Increased mortality of GF mice with high concentrations of DSS (S1); Tumors in GF mice have similar nuclear beta-catenin localization as tumors in SPF mice (S2); Percent weight change from baseline (start of DSS) for GF and SPF mice with AOM and 1.5% DSS (S3); Increased inflammatory cell recruitment in SPF mice early after DSS-induced intestinal injury (S4); Tumors in GF mice have similar proliferative activity as tumors in SPF mice (S5); Recolonization of GF mice with the gut microbiota reduces mortality to DSS (S6); Recolonization of GF mice with the gut microbiota restores ability of GF mice to induce reparative inflammation (S7).
Supplementary Figure 2 from Targeting Sonic Hedgehog-Associated Medulloblastoma through Inhibition of Aurora and Polo-like Kinases
Authors: Markant Shirley L. , Esparza Lourdes Adriana , Sun Jesse , Barton Kelly L. , McCoig Lisa M. , Grant Gerald A. , Crawford John R. , Levy Michael L. , Northcott Paul A. , Shih David , Remke Marc , Taylor Michael D. , Wechsler-Reya Robert J.
Published: March 2023

PDF file - 1674K, Supplemental Figure 2: Aurk and Plk inhibitors block proliferation of patched mutant tumor cells.
Supplementary Figure S5 from Extracellular DNA in Pancreatic Cancer Promotes Cell Invasion and Metastasis
Authors: Wen Fushi , Shen Alex , Choi Andrew , Gerner Eugene W. , Shi Jiaqi
Published: March 2023

PDF file - 208K, Micronuclei in pancreatic cancer cells
Supplementary Table 1 from Disruption of Wild-Type IDH1 Suppresses D-2-Hydroxyglutarate Production in IDH1-Mutated Gliomas
Authors: Jin Genglin , Reitman Zachary J. , Duncan Christopher G. , Spasojevic Ivan , Gooden David M. , Rasheed B. Ahmed , Yang Rui , Lopez Giselle Y. , He Yiping , McLendon Roger E. , Bigner Darell D. , Yan Hai
Published: March 2023

PDF file-22KB, D-2HG in primary human glioma tissue samples, as assessed by LC-MS/MS
Supplementary Figure 3 from Disruption of Wild-Type IDH1 Suppresses D-2-Hydroxyglutarate Production in IDH1-Mutated Gliomas
Authors: Jin Genglin , Reitman Zachary J. , Duncan Christopher G. , Spasojevic Ivan , Gooden David M. , Rasheed B. Ahmed , Yang Rui , Lopez Giselle Y. , He Yiping , McLendon Roger E. , Bigner Darell D. , Yan Hai
Published: March 2023

PDF file-101KB, Mutant IDH1 in the absence of wild type IDH1 is not sufficient to efficiently produce D-2HG in HCT116 cells
Supplementary Figure S2 from Extracellular DNA in Pancreatic Cancer Promotes Cell Invasion and Metastasis
Authors: Wen Fushi , Shen Alex , Choi Andrew , Gerner Eugene W. , Shi Jiaqi
Published: March 2023

PDF file - 610K, Inactivated DNase I has no effect on exDNA
Supplementary Figure S1 from Extracellular DNA in Pancreatic Cancer Promotes Cell Invasion and Metastasis
Authors: Wen Fushi , Shen Alex , Choi Andrew , Gerner Eugene W. , Shi Jiaqi
Published: March 2023

PDF file - 170K, Apoptosis level is higher in HPDE Cells than in BxPc3 cells
Supplementary Figure 1 from Disruption of Wild-Type IDH1 Suppresses D-2-Hydroxyglutarate Production in IDH1-Mutated Gliomas
Authors: Jin Genglin , Reitman Zachary J. , Duncan Christopher G. , Spasojevic Ivan , Gooden David M. , Rasheed B. Ahmed , Yang Rui , Lopez Giselle Y. , He Yiping , McLendon Roger E. , Bigner Darell D. , Yan Hai
Published: March 2023

PDF file-31KB, Synthesis of octyl-�-ketoglutarate
Supplementary Materials and Methods from A Synthetic Lethality–Based Strategy to Treat Cancers Harboring a Genetic Deficiency in the Chromatin Remodeling Factor BRG1
Authors: Oike Takahiro , Ogiwara Hideaki , Tominaga Yuichi , Ito Kentaro , Ando Osamu , Tsuta Koji , Mizukami Tatsuji , Shimada Yoko , Isomura Hisanori , Komachi Mayumi , Furuta Koh , Watanabe Shun-Ichi , Nakano Takashi , Yokota Jun , Kohno Takashi
Published: March 2023

PDF files, 147K.
Supplementary Materials and Methods from Obesity Promotes Breast Cancer by CCL2-Mediated Macrophage Recruitment and Angiogenesis
Authors: Arendt Lisa M. , McCready Jessica , Keller Patricia J. , Baker Dana D. , Naber Stephen P. , Seewaldt Victoria , Kuperwasser Charlotte
Published: March 2023

PDF file, 102K, Description of additional methods and procedures used in the study. Also includes supplemental references.
Supplementary Figure Legends from Obesity Promotes Breast Cancer by CCL2-Mediated Macrophage Recruitment and Angiogenesis
Authors: Arendt Lisa M. , McCready Jessica , Keller Patricia J. , Baker Dana D. , Naber Stephen P. , Seewaldt Victoria , Kuperwasser Charlotte
Published: March 2023

PDF file, 93K.
Supplementary Figure 5 from Obesity Promotes Breast Cancer by CCL2-Mediated Macrophage Recruitment and Angiogenesis
Authors: Arendt Lisa M. , McCready Jessica , Keller Patricia J. , Baker Dana D. , Naber Stephen P. , Seewaldt Victoria , Kuperwasser Charlotte
Published: March 2023

PDF file, 1009K, Characterization of SVF/EV and SVF/CCL2-derived end stage tumors.
Supplementary Figure 3 from Obesity Promotes Breast Cancer by CCL2-Mediated Macrophage Recruitment and Angiogenesis
Authors: Arendt Lisa M. , McCready Jessica , Keller Patricia J. , Baker Dana D. , Naber Stephen P. , Seewaldt Victoria , Kuperwasser Charlotte
Published: March 2023

PDF file, 390K, Macrophage-derived CXCL12 increases angiogenesis.
Supplementary Figure 4 from An Antibody That Locks HER3 in the Inactive Conformation Inhibits Tumor Growth Driven by HER2 or Neuregulin
Authors: Garner Andrew P. , Bialucha Carl U. , Sprague Elizabeth R. , Garrett Joan T. , Sheng Qing , Li Sharon , Sineshchekova Olga , Saxena Parmita , Sutton Cammie R. , Chen Dongshu , Chen Yan , Wang Huiqin , Liang Jinsheng , Das Rita , Mosher Rebecca , Gu Jian , Huang Alan , Haubst Nicole , Zehetmeier Carolin , Haberl Manuela , Elis Winfried , Kunz Christian , Heidt Analeah B. , Herlihy Kara , Murtie Joshua , Schuller Alwin , Arteaga Carlos L. , Sellers William R. , Ettenberg Seth A.
Published: March 2023

PDF file - 272K, Figure S4. The NRG1/ HER3 binding affinity is unaffected by LJM716.
Supplementary Figure 2 from An Antibody That Locks HER3 in the Inactive Conformation Inhibits Tumor Growth Driven by HER2 or Neuregulin
Authors: Garner Andrew P. , Bialucha Carl U. , Sprague Elizabeth R. , Garrett Joan T. , Sheng Qing , Li Sharon , Sineshchekova Olga , Saxena Parmita , Sutton Cammie R. , Chen Dongshu , Chen Yan , Wang Huiqin , Liang Jinsheng , Das Rita , Mosher Rebecca , Gu Jian , Huang Alan , Haubst Nicole , Zehetmeier Carolin , Haberl Manuela , Elis Winfried , Kunz Christian , Heidt Analeah B. , Herlihy Kara , Murtie Joshua , Schuller Alwin , Arteaga Carlos L. , Sellers William R. , Ettenberg Seth A.
Published: March 2023

PDF file - 268K, Figure S2. LJM716 inhibits HER3 mediated PI3K signaling.
Supplementary Table 1 from PIK3CA Mutation H1047R Is Associated with Response to PI3K/AKT/mTOR Signaling Pathway Inhibitors in Early-Phase Clinical Trials
Authors: Janku Filip , Wheler Jennifer J. , Naing Aung , Falchook Gerald S. , Hong David S. , Stepanek Vanda M. , Fu Siqing , Piha-Paul Sarina A. , Lee J. Jack , Luthra Rajyalakshmi , Tsimberidou Apostolia M. , Kurzrock Razelle
Published: March 2023

PDF file - 46K, Therapies targeting PI3K/AKT/mTOR pathway
Supplementary Figures 1 - 6, Table 1 from Interleukin-1β Promotes Skeletal Colonization and Progression of Metastatic Prostate Cancer Cells with Neuroendocrine Features
Authors: Liu Qingxin , Russell Mike R. , Shahriari Kristina , Jernigan Danielle L. , Lioni Mercedes I. , Garcia Fernando U. , Fatatis Alessandro
Published: March 2023

PDF file - 1996K, Supplementary Figure 1. Metastatic progression of different human prostate cancer cells in the skeleton of animal model. Supplementary Figure 2. Identification of pro-metastatic genes regulated by PDGFRa in PC3 cells. Supplementary Figure 3. Genes regulated by PDGFRa in DU-145 cells, which did not acquire bone-metastatic behavior upon exogenous expression of this receptor. Supplementary Figure 4. Two single-cell progenies of PC3-ML cells with high bone-metastatic potential. Supplementary Figure 5. Analysis of IL-1b expression and secretion from prostate cancer cells. Supplementary Figure 6. PDGFRa regulates Elafin and CXCL6 expression in prostate cancer cells. Supplementary Table 1. Contingency table of TMA data showing that prostate tumors with Gleason scores (≥7) expressed higher levels of the IL-1b protein as compared to tumors with lower Gleason scores (<7) (E). Chi-square = 33.08 and p<0.0001
Supplementary Figure 3 from Stem Cell Differentiation and Lumen Formation in Colorectal Cancer Cell Lines and Primary Tumors
Authors: Ashley Neil , Yeung Trevor M. , Bodmer Walter F.
Published: March 2023

PDF file, 266K, DMOG Induces Expression of Hif1alpha and hypoxia regulated genes Glut1 and Carbonic Anhydrase IX.
Supplementary Figure 2 from Stem Cell Differentiation and Lumen Formation in Colorectal Cancer Cell Lines and Primary Tumors
Authors: Ashley Neil , Yeung Trevor M. , Bodmer Walter F.
Published: March 2023

PDF file, 287K, Lumen colonies express polarised enterocyte markers.
Supplementary Figure Legends from Src Family Kinases as Novel Therapeutic Targets to Treat Breast Cancer Brain Metastases
Authors: Zhang Siyuan , Huang Wen-Chien , Zhang Lin , Zhang Chenyu , Lowery Frank J. , Ding Zhaoxi , Guo Hua , Wang Hai , Huang Suyun , Sahin Aysegul A. , Aldape Kenneth D. , Steeg Patricia S. , Yu Dihua
Published: March 2023

PDF file, 87K.
Supplementary Figure Legends from GM-CSF Promotes the Immunosuppressive Activity of Glioma-Infiltrating Myeloid Cells through Interleukin-4 Receptor-α
Authors: Kohanbash Gary , McKaveney Kayla , Sakaki Masashi , Ueda Ryo , Mintz Arlan H. , Amankulor Nduka , Fujita Mitsugu , Ohlfest John R. , Okada Hideho
Published: March 2023

PDF file, 89K.
Supplementary Figure 4 from GM-CSF Promotes the Immunosuppressive Activity of Glioma-Infiltrating Myeloid Cells through Interleukin-4 Receptor-α
Authors: Kohanbash Gary , McKaveney Kayla , Sakaki Masashi , Ueda Ryo , Mintz Arlan H. , Amankulor Nduka , Fujita Mitsugu , Ohlfest John R. , Okada Hideho
Published: March 2023

PDF file, 129K, Critical role of IL-4Ralpha in T-cell-suppressing function of BM-derived myeloid cells.
Supplementary Figure S3 from Melanoma-Educated CD14+ Cells Acquire a Myeloid-Derived Suppressor Cell Phenotype through COX-2–Dependent Mechanisms
Authors: Mao Yumeng , Poschke Isabel , Wennerberg Erik , Pico de Coaña Yago , Egyhazi Brage Suzanne , Schultz Inkeri , Hansson Johan , Masucci Giuseppe , Lundqvist Andreas , Kiessling Rolf
Published: March 2023

Supplementary Figure S3 - PDF file 73K, Melanoma cells induce MDSC-like cells through COX-2/PGE2 production
Supplementary Figure 2 from GM-CSF Promotes the Immunosuppressive Activity of Glioma-Infiltrating Myeloid Cells through Interleukin-4 Receptor-α
Authors: Kohanbash Gary , McKaveney Kayla , Sakaki Masashi , Ueda Ryo , Mintz Arlan H. , Amankulor Nduka , Fujita Mitsugu , Ohlfest John R. , Okada Hideho
Published: March 2023

PDF file, 129K, IL-4Ralpha on CD11b+Gr1+ BILs and SPCs.
Supplementary Figure 3 from PanIN-Specific Regulation of Wnt Signaling by HIF2α during Early Pancreatic Tumorigenesis
Authors: Criscimanna Angela , Duan Li-Juan , Rhodes Julie A. , Fendrich Volker , Wickline Emily , Hartman Douglas J. , Monga Satdarshan P.S. , Lotze Michael T. , Gittes George K. , Fong Guo-Hua , Esni Farzad
Published: March 2023

Supplementary Figure 3 - PDF file 2443K, PanIN-specific loss of �-catenin in PKH2 pancreas
Supplementary Material from Androgen Receptor-Independent Function of FoxA1 in Prostate Cancer Metastasis
Authors: Jin Hong-Jian , Zhao Jonathan C. , Ogden Irene , Bergan Raymond C. , Yu Jindan
Published: March 2023

Supplementary Material - PDF file 1368K, Figure S1. FoxA1 promotes cell cycle progress ion but inhibits cell motility. Figure S2. FoxA1 promotes cell pro liferation through the AR. Figure S3. FoxA1 inhibits PC-3M cell inva sion independently of the AR. Figure S4. WB analysis of Vimentin in FoxA1 knockdown LNCaP cells. Figure S5. FoxA1 directly suppresses SLUG expression. Figure S6. FoxA1 expression is up-regulated in localized PCa, but is significantly down- regulated in metastatic PCa. Figure S7. FoxA1 mutants fail to bind the SLUG enhancer. Table S1. GO analysis of genes repressed by shFoxA1 (i .e. FoxA1-induced genes) in LNCaP cells. Table S2. GO analysis of genes induced by shFoxA1 (i.e. FoxA1-repressed) in LNCaP cells. Table S3. GO analysis of genes repressed by siFoxA1 (i .e. FoxA1-induced genes) in LNCaP cells. Table S4. GO analysis of genes induced by siFoxA1 (i .e. FoxA1-repressed) in LNCaP cells. Table S5. GO analysis of genes repressed by shFoxA1 (i .e. FoxA1-induced genes) in 22RV1 cells. Table S6. GO analysis of genes induced by shFoxA1 (i.e. FoxA1-repressed) 22RV1 cells. Table S7. Sequences of oligonucleotid es used in this study
Supplementary Table 3 from NSD2 Is Recruited through Its PHD Domain to Oncogenic Gene Loci to Drive Multiple Myeloma
Authors: Huang Zheng , Wu Haiping , Chuai Shannon , Xu Fiona , Yan Feng , Englund Nathan , Wang Zhaofu , Zhang Hailong , Fang Ming , Wang Youzhen , Gu Justin , Zhang Man , Yang Teddy , Zhao Kehao , Yu Yanyan , Dai Jingquan , Yi Wei , Zhou Shaolian , Li Qian , Wu Jing , Liu Jun , Wu Xu , Chan Homan , Lu Chris , Atadja Peter , Li En , Wang Yan , Hu Min
Published: March 2023

XLSX file, 450K, Gene set enrichment analysis (GSEA) reports for comparisons of PAR_TKO and active_inactive groups.
Supplementary Table 3 from Proteomic and Lipidomic Signatures of Lipid Metabolism in NASH-Associated Hepatocellular Carcinoma
Authors: Muir Kyle , Hazim Antonious , He Ying , Peyressatre Marion , Kim Do-Young , Song Xiaoling , Beretta Laura
Published: March 2023

Supplementary Table 3�- PDF file 106K, Lipogenic proteins identified by LC-MS/MS in Pten null liver
Supplementary Figure 2 from Specific Recruitment of γδ Regulatory T Cells in Human Breast Cancer
Authors: Ye Jian , Ma Chunling , Wang Fang , Hsueh Eddy C. , Toth Karoly , Huang Yi , Mo Wei , Liu Shuai , Han Bing , Varvares Mark A. , Hoft Daniel F. , Peng Guangyong
Published: March 2023

PDF file, 2822K, Correlation analyses of tumor-infiltrating �� T cells and tumor IP-10 expression levels in human breast cancer tissues.
Supplementary Figure and Table Legends from Proteomic and Lipidomic Signatures of Lipid Metabolism in NASH-Associated Hepatocellular Carcinoma
Authors: Muir Kyle , Hazim Antonious , He Ying , Peyressatre Marion , Kim Do-Young , Song Xiaoling , Beretta Laura
Published: March 2023

Supplementary Figure and Table Legends�- PDF file 72K, Legend for Supplementary Tables S1-S2 and Supplementary Figures S1-S4
Supplementary Figure 3 from Proteomic and Lipidomic Signatures of Lipid Metabolism in NASH-Associated Hepatocellular Carcinoma
Authors: Muir Kyle , Hazim Antonious , He Ying , Peyressatre Marion , Kim Do-Young , Song Xiaoling , Beretta Laura
Published: March 2023

Supplementary Figure 3�- PDF file 109K, Changes in circulating fatty acids (free fatty acids) (relative composition in %) in Pten null mice
Supplementary Figure 2 from Proteomic and Lipidomic Signatures of Lipid Metabolism in NASH-Associated Hepatocellular Carcinoma
Authors: Muir Kyle , Hazim Antonious , He Ying , Peyressatre Marion , Kim Do-Young , Song Xiaoling , Beretta Laura
Published: March 2023

Supplementary Figure 2�- PDF file 130K, Fatty acid changes (cholesterol esters) (relative composition in %) in Pten null liver
Supplementary Figure 1 from Proteomic and Lipidomic Signatures of Lipid Metabolism in NASH-Associated Hepatocellular Carcinoma
Authors: Muir Kyle , Hazim Antonious , He Ying , Peyressatre Marion , Kim Do-Young , Song Xiaoling , Beretta Laura
Published: March 2023

Supplementary Figure 1�- PDF file 138K, Fatty acid (free fatty acids) changes (relative composition in %) in Pten null liver
Supplementary Methods from miR-214 Coordinates Melanoma Progression by Upregulating ALCAM through TFAP2 and miR-148b Downmodulation
Authors: Penna Elisa , Orso Francesca , Cimino Daniela , Vercellino Irene , Grassi Elena , Quaglino Elena , Turco Emilia , Taverna Daniela
Published: March 2023

Supplementary Methods - PDF file 95K, Additional information regarding all reagents, antibodies, vectors and primers employed in this study, including experimental procedures
Supplementary Figure 1 from Therapeutic Effects of Deleting Cancer-Associated Fibroblasts in Cholangiocarcinoma
Authors: Mertens Joachim C. , Fingas Christian D. , Christensen John D. , Smoot Rory L. , Bronk Steven F. , Werneburg Nathan W. , Gustafson Michael P. , Dietz Allan B. , Roberts Lewis R. , Sirica Alphonse E. , Gores Gregory J.
Published: March 2023

PDF file - 62K, LX-2 and hCAF display an activated phenotype by α-smooth muscle actin and tenascin C mRNA expression
Supplementary Figures from Dysregulated Hematopoiesis Caused by Mammary Cancer Is Associated with Epigenetic Changes and Hox Gene Expression in Hematopoietic Cells
Authors: Sio Alexander , Chehal Manreet K. , Tsai Kevin , Fan Xueling , Roberts Morgan E. , Nelson Brad H. , Grembecka Jolanta , Cierpicki Tomasz , Krebs Danielle L. , Harder Kenneth W.
Published: March 2023

PDF file, 353K, Supplemental Figure S1: Mammary tumors induce significant changes in granulocyte and monocyte numbers in mice. Supplemental Figure S2: 4T1 tumor development is associated with impaired BM myelopoiesis and erythropoiesis, and disrupts the BM hematopoietic stem/progenitor compartment. Supplemental Figure S3. Melanoma tumor development is not associated with impaired BM erythropoiesis and does not disrupt the BM hematopoietic stem/progenitor compartment. Supplemental Figure S4. Mammary tumor conditioned media significantly expands hematopoietic progenitors in BM cultures supplemented with GM-CSF and identification of relevant cytokines produced by MT-1 cells for hematopoietic progenitor expansion. Supplemental Figure S5. Mammary tumor conditioned media increases hematopoietic progenitor cell proliferation and decreases LSK death in in vitro BM cultures supplemented with FLT3L or GM-CSF. Supplemental Figure S6: Mammary tumor-conditioned media (MT-1-CM) is associated with changes in histone modifying protein expression and histone methylation. Supplemental Figure S7: Mammary tumor conditioned media treatment is associated with changes in G-CSF induced changes in histone methylation at the Hoxa9 locus.
Supplementary Figure 2 from CDK1 Phosphorylation of YAP Promotes Mitotic Defects and Cell Motility and Is Essential for Neoplastic Transformation
Authors: Yang Shuping , Zhang Lin , Liu Miao , Chong Rong , Ding Shi-Jian , Chen Yuanhong , Dong Jixin
Published: March 2023

PDF file 210K, Identification of Phosphorylation Sites on YAP.
Supplementary Tables 1 - 4 from BCCIP Suppresses Tumor Initiation but Is Required for Tumor Progression
Authors: Huang Yi-Yuan , Dai Li , Gaines Dakim , Droz-Rosario Roberto , Lu Huimei , Liu Jingmei , Shen Zhiyuan
Published: March 2023

PDF file - 64K, Sequences of primers used for genotyping (S1); Primer information for qPCR (S2); Primers used to amplify and sequence the cDNA of BCCIP, PTEN, and Ptch1 fragments (S3); The fractions of the medulloblastoma that have altered mRNA expression of the SHH pathway components (Results based on q-PCR analysis) (S4).
Supplementary Table 2 from Double Minute Chromosomes in Glioblastoma Multiforme Are Revealed by Precise Reconstruction of Oncogenic Amplicons
Authors: Sanborn J. Zachary , Salama Sofie R. , Grifford Mia , Brennan Cameron W. , Mikkelsen Tom , Jhanwar Suresh , Katzman Sol , Chin Lynda , Haussler David
Published: March 2023

PDF file, 634K, BamBam output of peaks and rearrangements for TCGA-GBM-0145, TCGA-GBM-0152 and TCGA-GBM-0648 (Whole Genome Sequence analysis).
Supplementary Figure 5 from Tumor Suppressor Function of the Plasma Glutathione Peroxidase Gpx3 in Colitis-Associated Carcinoma
Authors: Barrett Caitlyn W. , Ning Wei , Chen Xi , Smith Jesse Joshua , Washington Mary K. , Hill Kristina E. , Coburn Lori A. , Peek Richard M. , Chaturvedi Rupesh , Wilson Keith T. , Burk Raymond F. , Williams Christopher S.
Published: March 2023

PDF file - 1856K, Intratumoral apoptosis is not altered in Gpx3-/- mice. TUNEL immunohistochemistry was performed to identify apoptotic cells in WT (N=13) and Gpx3-/- (N=14) tumors. TUNEL+ cells were counted within each high-powered field (HPF) and then averaged for each mouse. P=n.s.
Supplementary Figure 4 from Tumor Suppressor Function of the Plasma Glutathione Peroxidase Gpx3 in Colitis-Associated Carcinoma
Authors: Barrett Caitlyn W. , Ning Wei , Chen Xi , Smith Jesse Joshua , Washington Mary K. , Hill Kristina E. , Coburn Lori A. , Peek Richard M. , Chaturvedi Rupesh , Wilson Keith T. , Burk Raymond F. , Williams Christopher S.
Published: March 2023

PDF file - 2173K, Absence of Gpx3 does not modify weight change in response to AOM/DSS exposure. Percentage weight loss at day 0 and day 7 of each cycle throughout the course of the AOM/DSS protocol. P=n.s.
Supplementary Figure Legend from ATR Inhibition Broadly Sensitizes Ovarian Cancer Cells to Chemotherapy Independent of BRCA Status
Authors: Huntoon Catherine J. , Flatten Karen S. , Wahner Hendrickson Andrea E. , Huehls Amelia M. , Sutor Shari L. , Kaufmann Scott H. , Karnitz Larry M.
Published: March 2023

PDF file - 61K
Supplementary Figure 3 from ATR Inhibition Broadly Sensitizes Ovarian Cancer Cells to Chemotherapy Independent of BRCA Status
Authors: Huntoon Catherine J. , Flatten Karen S. , Wahner Hendrickson Andrea E. , Huehls Amelia M. , Sutor Shari L. , Kaufmann Scott H. , Karnitz Larry M.
Published: March 2023

PDF file - 50K, Supplementary Figure 3. MK-8776 and VE821 fail to inhibit Chk1 phosphorylation induced by a wide range of cisplatin concentrations.
Supplementary Table 1 from AC1MMYR2, an Inhibitor of Dicer-Mediated Biogenesis of Oncomir miR-21, Reverses Epithelial–Mesenchymal Transition and Suppresses Tumor Growth and Progression
Authors: Shi Zhendong , Zhang Junxia , Qian Xiaomin , Han Lei , Zhang Kailiang , Chen Luyue , Liu Jilong , Ren Yu , Yang Ming , Zhang Anling , Pu Peiyu , Kang Chunsheng
Published: March 2023

XLSX file - 688K, 1,990 NCI diversity compounds were screened for high-throughput molecular docking through employing Auto Dock programs.
Supplementary Figures 1 - 11 from AC1MMYR2, an Inhibitor of Dicer-Mediated Biogenesis of Oncomir miR-21, Reverses Epithelial–Mesenchymal Transition and Suppresses Tumor Growth and Progression
Authors: Shi Zhendong , Zhang Junxia , Qian Xiaomin , Han Lei , Zhang Kailiang , Chen Luyue , Liu Jilong , Ren Yu , Yang Ming , Zhang Anling , Pu Peiyu , Kang Chunsheng
Published: March 2023

PDF file - 1027K, (S1)Pipeline of the 3D structure prediction of pre-miR-21 hairpin loop. (S2) Real-time PCR assayed the miR-21 relative expression after the treatment of the top five compounds and As-miR-21. (S3) AC1MMYR2 selectively targets miR-21-high expression tumor cells (S4) AC1MMYR2 inhibited proliferation and induced apoptosis in LN229 and SGC7901 cancer cells. (S5) AC1MMYR2 suppressed the migration and invasion in LN229 and SGC7901 tumor cells. (S6) AC1MMYR2 displayed no toxicity to normal organs. (S7) AC1MMYR2 impacts on miR-21 and its functional targets expressions in MDA-MB-231 cells. (S8) AC1MMYR2 inhibited proliferation and induced apoptosis in MDA-MB-231 cells. (S9) AC1MMYR2 suppressed tumor cell invasion and migration in MDA-MB-231 cells. (S10) Histological evidences of the MCF-7 and MDA-MB-231 tumor phenotype. (S11) AC1MMYR2 mechanism of action was exhibited in schematic diagram.
Supplementary Methods from Neuropilin-2 Is Upregulated in Lung Cancer Cells during TGF-β1–Induced Epithelial–Mesenchymal Transition
Authors: Nasarre Patrick , Gemmill Robert M. , Potiron Vincent A. , Roche Joëlle , Lu Xian , Barón Anna E. , Korch Christopher , Garrett-Mayer Elizabeth , Lagana Alessandro , Howe Philip H. , Drabkin Harry A.
Published: March 2023

PDF file - 70K
Supplementary Figure 4 from Critical Role of STAT3 in IL-6–Mediated Drug Resistance in Human Neuroblastoma
Authors: Ara Tasnim , Nakata Rie , Sheard Michael A. , Shimada Hiroyuki , Buettner Ralf , Groshen Susan G. , Ji Lingyun , Yu Hua , Jove Richard , Seeger Robert C. , DeClerck Yves A.
Published: March 2023

Supplementary Figure 4 - PDF file 91K, A. Representative data of the analysis on one fresh patient bone marrow sample by Flow Cytometry showing the expression of pSTAT3 in various sub-populations of bone marrow cells as indicated in Materials and Methods. B. Left panel: Percentage of the 6 sub-populations of cells identified as shown in A. The data represents the mean percentage (�SD) of all mononuclear cells isolated from 8 individual patient samples. Right panel: The data represents the mean percentage of pSTAT3 positivity in each sub-population of bone marrow cells identified in the 8 samples as shown in the left panel