bluuebunny/crossref_metadata_2025 huggingface dataset:
Caracterización de la población gestante con infección confirmada por SARS-CoV-2 en la ciudad de Cali
Authors: Capera Mendoza Diana Marcela , Hernández Carrillo Mauricio , Gómez Gómez Milton Cesar , Paz Fernando Felipe , Cubides Munevar Ángela Mayerly , Holguín Ruíz Jorge Alirio
Published: May 2022

La infección por Síndrome Respiratorio Agudo Severo por Coronavirus 2 (SARS CoV2) en los últimos meses afecto a toda la población mundial generando enfermedad crítica y altos índices de mortalidad, constituyendo un problema en salud pública. Los datos a nivel nacional respecto a la población gestante asociados a la transmisión del virus son escasos. El objetivo es caracterizar la población embarazada en la ciudad de Cali con prueba de hisopado nasofaríngeo positiva, conocer las manifestaciones clínicas en el momento que se sospechó el diagnosticó y comportamiento de la enfermedad. Se utilizó los datos registrados en la ficha 346 del Sistema de Vigilancia Epidemiológica lo cual es realizada por el personal médico de las instituciones de salud a todas las gestantes que se catalogaron como sospechosas para Síndrome respiratorio agudo severo por Coronavirus 2 , desde 1 marzo 2020 al 31 de diciembre del 2020 obteniendo las 229 mujeres positivas para la infección. Se encontró que eran mujeres jóvenes en promedio de edad de 28.8 +/- 5.6 años, el 97.3% eran pacientes de nacionalidad colombiana, seguida por un 3.1% de nacionalidad venezolana. El 7 % de las gestantes requirió manejo de hospitalización. En el requerimiento UCI de las 229 gestantes, solo el 3.1 % tuvieron criterios para su estadía en este servicio. El síntoma más frecuente encontrada en nuestra población fue la tos en un 55.5%. La comuna más afectada fue la 15. En conclusión, la presentación del Síndrome respiratorio agudo severo por Coronavirus 2 afecta a cualquier tipo de población, en nuestro caso la comunidad más afectada es de bajo estrato social con mayor riesgo de vulnerabilidad. En la presentación clínica no difiere mucho a la encontrada en la población mundial.
The Phenomenon of Forgetting and the Dialogue of Cultures in the Globalizing Society: the Russian Experience
Authors:   Saratov State University, Anikin D. A.
Published: May 2022

The article is devoted to phenomenon of forgetting as an integral element of dialogue of cultures in the being globalized world. It is possible to allocate not only ways of preservation of historical memory, but also types of forgetting in a context of sharp social transformations of society. A specific of historical amnesia in the conditions of modern Russian society consists in an attempt to correlate phenomena of live, communicative memory to essentially other political symbolics. Special relevance is gained by the appeal to the Soviet experience, and symbols of the Soviet era are exposed to code conversion taking into account new social and political phenomena.
El conocimiento situado en la Bibliotecología y Ciencia de la Información (CI): desafíos en el Antropoceno
Authors: Duque-Cardona Natalia , Restrepo-Fernández Maria Camila
Published: May 2022

Este artículo presenta el concepto de conocimiento situado desarrollado por Donna Haraway como posibilidad para transformar la perspectiva clásica de la Bibliotecología y la CI a la luz de los desafíos del Antropoceno y especialmente como idea que contribuye a la reducción de las desigualdades sociales mediante el acceso al capital cultural. Tomando como marco analítico la interculturalidad y en diálogo con teorías sociales como la interseccionalidad (Kimberlé Crenshaw; Patricia Hill Collins), el saber situado (Donna Haraway) y las escalas de justicia (Nancy Fraser) planteamos una serie de reflexiones que pueden contribuir a la reconfiguración de las disciplinas científicas en perspectiva crítica latinoamericana, vinculando la interculturalidad, y a redefinir nuestra posición como teóricos sociales. Se hace uso del pronombre y objeto directo femeninos para dirigirse a las personas sin importar su género o sexo
Redes digitales, conocimiento y postverdad: Los desafíos para la democracia en tiempos de pandemia
Authors: Lander Edgardo , Lang Miriam
Published: May 2022

Los regímenes de verdad que estuvieron vigentes, aunque siempre contestados, durante el siglo XX, están siendo aceleradamente socavados por diferentes factores: la creciente influencia de intereses corporativos en algunas ramas de la ciencia; la reconfiguración del ámbito de lo público por las redes digitales, igualmente gobernadas por lógicas oligopólicas de lucro; y el aprovechamiento de la pérdida de referentes compartidos por grupos de interés políticos, sobre todo las extremas derechas. La pandemia ha acelerado este proceso, que amenaza las posibilidades de construir salidas democráticas a la crisis múltiple y civilizatoria que están viviendo las sociedades humanas
Governança ambiental: transparência e efetividade de práticas sustentáveis em IES
Authors: Maruyama Úrsula , Trigo Aline Monteiro Guimarães , Trigo José Aires
Published: May 2022

A desinformação causada pelo modelo de desenvolvimento predatório, ambientalmente e socialmente injusto torna-se o cenário para uma reflexão crítica voltada a uma maior conscientização ambiental e urgente mudança de paradigmas. Considerando a importância de políticas públicas voltadas à sustentabilidade ambiental e o papel de interlocução com diversos atores que as instituições de ensino superior (IES) promovem, este artigo busca avaliar a percepção de gestores de campi universitários do Cefet-RJ quanto ao cumprimento das recomendações do Plano de Gestão de Logística Sustentável (PLS) em suas unidades. Para tanto, foi aplicado um questionário, com base na escala de Likert e, posteriormente, sob a perspectiva descritiva, as informações obtidas foram consolidadas. Observou-se que, embora as práticas efetivamente conduzidas já estejam alinhadas com a governança ambiental, ainda há necessidade de promover novas ações que estimulem cada vez mais a conscientização ambiental, não somente ‘intramuros’, mas também na formação cidadã. Apesar do estudo trazer uma reflexão baseada na percepção de gestores que avaliam a implementação das iniciativas, os resultados não permitem generalizações consistentes, mas visam contribuir para eventuais trabalhos, que busquem maior robustez, através do aumento do número de respondentes
No colapso, mas contra a distopia: alianças globais de lutas por justiça ecossocial e econômica no Antropoceno: entrevista com Maristella Svampa
Authors: Pereira Felipe Milanez , Lamas Isabella Alves
Published: May 2022

Nesta entrevista, a socióloga Maristella Svampa, uma das grandes expoentes da ecologia política latino-americana, apresenta reflexões entre a constatação de que vivemos um colapso ecológico global, os limites e omissões das ciências sociais no Antropoceno, bem como a necessidade da transdisciplinariedade e da conexão das agendas de luta em diferentes escalas para se construir novos horizontes.
Deixadas para morrer: sobre búfalas, desinformação e especismo estrutural
Authors: Oliveira Fabio Alves Gomes de , Amaral Érica Quadros do
Published: May 2022

Neste artigo, analisamos o caso que ficou conhecido como “Búfalas de Brotas” para introduzir a discussão sobre o conceito de especismo estrutural, situando o especismo como um dos componentes do sistema de opressões. Abordamos o aspecto informacional que envolve o caso por meio das narrativas identificadas na cobertura midiática do acontecimento. Ampliamos o debate para o viés informacional, ressaltando a necessidade da inserção de elementos políticos. Contextualizamos o especismo estrutural como estratégia de elevação do agronegócio que conta com outras instituições de poder como auxiliares no enviesamento da opinião pública, favorecendo a manutenção dos interesses deste setor e sua contínua expansão em detrimento da qualidade de vida de animais não humanos e humanos. Como metodologia, adotamos a revisão bibliográfica, correlacionando o arcabouço teórico dos saberes da Ciência da Informação, Estudos Críticos Animalistas, Ecofeminismos e análise do mencionado caso paradigmático por meio de relatos divulgados pela mídia para apuração da complexa trama que chamamos de “paradoxo da opressão”, envolvendo o movimento de ativismo em defesa da causa animal, a mídia e o agronegócio. Nossas considerações finais nos direcionam ao entendimento do especismo estrutural como um problema de ordem informacional por ser produto de estratégias de desinformação e desempenhar o papel de provimento do senso comum, produção de ignorância e manutenção de estruturas de poder que asseguram sua própria existência como um modo de opressão que impacta animais não humanos e humanos
A Disputa do Tempo: dialogia informacional e teoria da história no movimento zapatista
Authors: Rihan Bianca , Sette Jos´´e Raphael
Published: May 2022

O presente artigo se dedica à discussão sobre “documentos rebeldes”, dispostos a denunciar as falácias do progresso orientado pela lógica capitalista de acumulação e exploração, confeccionados pelos indígenas zapatistas em seu território, no sudeste mexicano. Nesse sentido, abordamos uma discussão oriunda da história econômica e da práxis revolucionária sobre o tempo e a teoria da história, acentuando o encontro crítico entre uma perspectiva epistemológica e prático-informacional. Tendo como princípios incontornáveis a dignidade humana, a conexão e o respeito à natureza e a busca de liberdade dos povos subalternizados ao longo da história, tomar conhecimento sobre a experiência zapatista nos reativa a esperança por um outro tempo e um “outro mundo possível”
The Ligature Assessment Tool: the development of a structured tool to improve quality of reporting of ligature incidents
Authors: Panchal Reena , Baker James , Scally Ruth , Attard Stephen
Published: May 2022

Of all deaths by suicide on psychiatric wards, 75% are due to hanging or strangulation by ligature. The act of tying a ligature is complex self harm risk behaviour and can be fatal. There is no consistent framework available to ensure that essential risk information is accurately captured
following a patient tying a ligature. This leads to a variable quality of incident reports being generated in inpatient psychiatric wards, which can be challenging for the MDT to interpret second hand and understand the ligature risk in that case. Effective psychiatric care is underpinned
by accurate and detailed documentation; thus comprehensive recording of ligature incidents is essential for recognising trends and risk factors, and in building a 'ligature tying profile'. A 'Ligature Assessment Tool' was developed to ensure that certain aspects of a ligature risk incident
were recorded in a systematic way on the incident reporting system. The tool consists of 15 criteria and is in a semi-structured format. This was rolled out in a regional female medium secure unit. There was clear improvement in the quality of reports, with an increase in the detail included.
For two patients, a 'ligature tying profile' was identified. Staff felt that the tool improved their documentation and was highly usable. Further work is ongoing; there is interest in use of the tool in general adult services and also in the national high secure service for women.
Endovascular treatment of penetrating nail gun injury of the cervical spine and vertebral artery: a case report
Authors: Christodoulides Alexei , Mitchell Scott , Bohnstedt Bradley N.
Published: May 2022

In this report, we present a case of high cervical penetrating trauma with vertebral artery injury and outline preprocedural, procedural, and postprocedural considerations with recommendations for the treatment of similar injuries. Management involves multiple imaging modalities, including X-ray imaging, computed tomography, computed tomography angiography, magnetic resonance imaging, and catheter angiography. We recommend endovascular treatment of these injuries when possible, based on the improved ability to achieve proximal and distal control and manage hemorrhage risk.
Bilevel Optimization of Well Placement and Control Settings Assisted by Capacitance-Resistance Models
Authors: Arouri Yazan , Lake Larry W. , Sayyafzadeh Mohammad
Published: May 2022

Well control and well placement optimization have typically been considered as separate problems. More recently, there have been a number of works which have shown improved results when these two problems are considered in a joint manner. However, this joint optimization problem, whether in a sequential or simultaneous manner, is more computationally demanding. In light of this, we propose the use of capacitance-resistance models (CRMs) to assist the computational demand of the joint optimization of well controls and well placement. Specifically, we use a bilevel (or nested) approach, where the outer loop is the well placement problem and the inner loop is the well control problem assisted by CRMs. The well placement problem is solved using particle swarm optimization (PSO), and the well control problem is solved using Adam-simultaneous perturbation stochastic approximation (SPSA). The proposed approach is compared with the conventional implementation using only high fidelity full-physics simulations on two reservoir models of varying complexity. We also investigate the accuracy of the CRMs during the optimization procedure. The proposed approach resulted in solutions for the joint optimization problems with objective function values of up to 21.8% higher than the conventional approach and up to a 99.6% decrease in the number of required reservoir simulations.
Rapid Sharing of Islamophobic Hate on Facebook: The Case of the Tablighi Jamaat Controversy
Authors: Ghasiya Piyush , Sasahara Kazutoshi
Published: May 2022

The COVID-19 pandemic brought about several challenges in addition to the virus itself. The rise of Islamophobic hate speech on social media is one such challenge. As countries were coping with economic collapse due to mass lockdown, hateful people, especially those associated with far-right groups, were targeting and blaming Muslims for the spread of the coronavirus. In India where intense religious/communal polarization is taking place under the right-wing Bhartiya Janata Party (BJP) led government, one such prominent instance of Islamophobia—the “Tablighi Jamaat Controversy” (TJC)—occurred. This article analyzes Facebook posts by public groups over a five-month period (March to August 2020) to find the major actors and track their link-sharing behavior. We found that the Pro-BJP groups with a right-wing ideology spread Islamophobic hate speech, while other groups (anti-hate) worked to counter the hate. We also found that the hate disseminators were extremely active (three times faster) in sharing their content as compared to the anti-hate groups. Finally, our research indicated that the links most widely shared by the hate spreaders were mostly misinformation. These results explain the use of the Facebook platform to spread hate and misinformation, demonstrating how BJP’s pro-Hindu ideology and its attitude towards Muslims is directly and indirectly enabling these actors to spew hate against Muslims with no legal consequences.
The role of genetic polymorphism in predictive model of ATDH
Authors: Zhang Jingwei , Zhou Wei , Wang Zhenyang , Luo Ping , Xiang Wang , Liang Xiao , Yuan Jinyan , Zhou Yi , Deng Fei
Published: May 2022

BACKGROUND: To develop a predictive model for hepatotoxicity due to antituberculosis drugs using a machine learning approach combining general clinical features of the electronic medical record, laboratory indications and genetic features of key genes in the PXR/ALAS1/FOXO1 axis. METHODS: Using the occurrence of ATDH as the outcome variable, the data were screened for features and model construction based on general clinical features and laboratory test indications, combined with single nucleotide polymorphism characteristics of PXR, FOXO1 and ALAS1 genes, combined with Lasso regression and logistic regression to evaluate the model's goodness of fit, predictive efficacy, discrimination and consistency, and used clinical decision Curve analysis was used to assess the clinical applicability of the models. RESULTS: The best model had a discriminant efficacy C-index of 0.8164, sensitivity of 34.25%, specificity of 97.99%, positive predictive value of 78.13%, negative predictive value of 87.69%, consistency test Sp=0.896, maximum bias Emax=0.147, and mean bias Eave=0.017. In the validation set performance was close. The clinical decision curve shows the clinical applicability of the prediction model when the prediction risk threshold is between 0.1 and 0.8. CONCLUSION: The ATDH prediction model was constructed using a machine learning approach, combining general characteristics of the study population, laboratory indications and SNP features of PXR and FOXO1 genes with good fit and some predictive value, and has potential and value for clinical application.
Adsorption performance of eco-friendly thin film polymer nanocomposite membrane for effective removal of cationic dye
Authors: Natesan Gowriboy , Rajappan Kalaivizhi
Published: May 2022

Textile industries are one of the leading environmental pollutants, releasing harmful dye effluents. In many textile districts, the amount of excess color in treated textile effluent that exceeds regulatory limitations is still a major concern. The combining usage of nanomaterials and polymer material to solve these issues using various techniques. In this research, Graphene oxide - Copper Oxide (GO-CuO) nanomaterial incorporated into cellulose-acetate (CA), poly-ether sulfone (PES) blend polymer by using phase inversion process to fabricate thin film nanocomposite (TFN) membrane for removal of dye pollutant. The physiochemical properties of prepared TFN materials were studied by FT-IR, XRD, FESEM, AFM, TGA and mechanical strength analysis. Dye adsorption experiments performed with four typical water-soluble organic dyes methylene blue (MB), rhodamine blue (Rh. B), methyl orange (MO) and Congo red (CR). As a result, the fabricated TFN material it was proven as most effective adsorbent material for cationic dye molecules. Also, when the fabricated material was tested to a textile industry effluent sample, all physio-chemical properties exhibited a considerable decrease in concentrations when compared to the real textile effluent concentration. The treated effluents permitted for a relatively greater growth and germination index of Tropical amaranth roots than the textile effluent, demonstrating that phytotoxicity testing was also successful. The most effective temperature, concentration and pH were found to be 273K, 1×10− 5 M and pH-9. The fabricated TFN membrane material (GO-CuO @ CA-PES) can be recommended for water treatment applications.
Landslide Susceptibility Mapping along Manipur-Assam NH-37
Authors: Singh Kanwarpreet , Khaidem Sukhajit
Published: May 2022

Landslides are the most catastrophic geological natural hazard in mountainous terrain. To minimise and mitigate these threats, comprehensive landslide mitigation and management, landslide assessment, and susceptibility zonation are required. Various methods are established based on different assessment methodologies, which are classified into qualitative and quantitative approaches. GIS based landslide susceptibility mapping was carried out along the National Highway 37, which connects Assam and Manipur and is a vital lifeline for the state. Field visits, LANDSAT bands, and Google Earth were used to create a landslide inventory map along the road corridor. To perform landslide susceptibility zonation modelling based on Frequency Ratio, Shannon’s Entropy, and Weight of Evidence, thematic layers of several landslide causative elements were delineated. The study area has been categorized into five vulnerable zones: very low, low, moderate, high, and very high. The landslide susceptibility zonation map was validated using the area under curve and landslide density methods. The final map will be helpful for various stakeholders, including town planners, engineers, geotechnical engineers, and geologists, for development and construction activities along NH-37.
Evaluation of thiol-disulfide homeostasis and oxidative stress parameters in newborns receiving phototherapy
Authors: Demirtas Mehmet Semih , Erdal Huseyin
Published: May 2022

Background: The aim of our study was to evaluate oxidative stress and thiol-disulfide homeostasis in term newborns receiving phototheraphy.Methods: The study was planned as a single-blind, intervention study in a single center with 3 level neonatal intensive care unit to investigate the effect of phototherapy on the oxidative system in term newborns with hyperbilurbinemia. Neonates with hyperbilirubinaemia were treated with total body exposure photherapy technique for 18 hours using Novos® device. Blood samples of 28 term newborns were taken before and after phototherapy. Total and native thiol, total antioxidant status (TAS) and total oxidant status (TOS), oxidative stress index (OSI) levels were measured.Results: The 28 newborn patients included 15 (54%) males and 13 (46%) females with a mean birth weight of 3080.1± 366.5 g. Native and total thiol levels were found to be decreased in patients receiving photherapy (p=0.021, p=0.010). Besides, significantly lower TAS and TOS levels were found after photheraphy p=0.0001, p= 0.001). We found decreased thiol levels related to increased oxidative stress. We also determined significantly lower bilurubin levels after photheraphy (p=0.0001).Conclusion: In conclusion, we found that phototherapy treatment induced decreased oxidative stress associated with hyperbilirubinemia in neonates. Thiol disulfide homesotasis can be used as a marker of oxidative stress due to hyperbilirubinemia in the early period.
Development and pilot trial of online Guided Self-Help Cognitive Behavioral Therapy program for Bulimia Nervosa and Binge Eating Disorder in Japanese patients
Authors: Ohsako Noriaki , Kimura Hiroshi , Hashimoto Tasuku , Hosoda Yutaka , Inaba Yosuke , Iyo Masaomi , Nakazato Michiko
Published: May 2022

Objective: The purpose of this study was to develop an internet-based Guided Self-Help CBT (iGSH-CBT) for Bulimia Nervosa (BN) / Binge Eating Disorder (BED) for Japanese patients and to test its feasibility with a single-arm study. After baseline assessment, patients underwent a 16-week iGSH-CBT program, our Japanese adaption of the European-based Salut BN program. Evaluations were performed at baseline, after 8 weeks, at the end of the 16-week intervention, and at 2 months after treatment had ended. The primary outcome measure was the change in the weekly frequency of objective binging. Results: Participants were 9 female outpatients with BN (n=5) or BED (n=4), of whom 8 (88.9%) attended the assessment at the end of the 16-week intervention. Percent change of the weekly frequencies of objective binging was -4.40%. Although no significant change was observed in the weekly frequencies of objective bingeing, the abstinence rate from bulimic behaviours of those who completed the assessments was 25.0% at the end of treatment, and the drop-out rate was 11.1%. iGSH-CBT may be an acceptable and possibly even a preferred method of CBT delivery for Japanese patients with BN or BED, and our Japanese adaptation of Salut BN seems feasible.
Analysis of the space-time trends in open defecation in Nigeria
Authors: Gayawan Ezra , Somo-Aina Omodolapo , Kuti Oluwatosin
Published: May 2022

The practice of open defecation has persistently remained high in Nigeria despite the grave danger it poses to public and environmental health, and the several intervention programs put in place over the years to curtail the ugly practice. This study quantifies the space and time trends in open defecation practice in Nigeria with the aim of highlighting the changes that have taken place at various locations in Nigeria over a fifteen-year period. A Bayesian spatio-temporal model was applied to cross-section data obtained from the Nigeria Demographic and Health Survey conducted in 2003, 2008, 2013, and 2018, and inference was based on integrated nested Laplace approximation technique. The findings indicate a north-south spatio-temporal patterns that are similar among the rural and urban dwellers. States such as Kwara, Kogi, Oyo, Ondo, Osun, Ekiti, Enugu, and Ebonyi all of which are neighbors to each other are among those with persistent high prevalence of open defecation in the country. Given the diversity of the Nigerian population groups within the states, a more understanding of the socio-cultural standard of the different communities would be required to implement policies that recognize opportunities to explore, while being culturally responsive to community needs in ending open defecation in Nigeria.
Quenching of As-synthesized ZnSe nanorods to ZnSe/ZnO nanoparticles via Air Annealing
Authors: Gupta Prerna , Patel Pushpanjali , Sujata KM , Solanki Rekha Garg
Published: May 2022

In the present work ZnSe nanorods (NRs) have been synthesised using simple Co-precipitation method and as-synthesised sample annealed at 300 0 C in air atmosphere. The structural, morphological and optical properties of prepared samples have been investigated using x-rays diffraction (XRD), transmission electron microscope (TEM), UV-Visible and Photoluminescence (PL) spectroscopy techniques. The XRD results revealed the formation of hexagonal structure of as-synthesized ZnSe NRs which were elongated to the reflection (101). TEM micrographs confirmed the formation of nanorods. Air annealing quenched the hexagonal ZnSe NRs to the hexagonal ZnSe/ZnO nanoparticles. UV–visible absorption spectroscopy predicted the blue shift in band gap of NRs and NPs to the bulk band gap of ZnSe. The PL spectra and corresponding CIE diagram predicted the as-synthesized NRs and quenched NPs emitted bluish colour and found suitable for Blue LEDs and Lasers which are useful in medical, health, pharmaceutical and food industry.
Identification of Distinct Clinical Phenotypes of Cardiogenic Shock Using Machine Learning Consensus Clustering Approach
Authors: Wang Li , Zhang Yufeng , Yao Renqi , Chen Kai , Xu Qiumeng , Huang Renhong , Mao Zhiguo , Yu Yue
Published: May 2022

Background: Cardiogenic shock (CS) is a heterogeneous condition with multiple underlying causes and associated outcomes. Discriminating between different patterns of CS is still challenging. We tested the hypothesis that the machine learning (ML) consensus clustering method would identify CS phenotypes with unique clinical profiles and outcomes.Methods: Patients diagnosed with CS on admission from the electronic ICU (eICU) Collaborative Research Database were included in the current study. We performed an unsupervised ML consensus clustering analysis among 21,925 patients with CS. The optimal number of clusters was determined by examining the consensus matrix (CM) heat map, cumulative distribution function (CDF), cluster-consensus plots, and the proportion of ambiguously clustered pairs (PAC) analysis. We calculated the standardized mean difference (SMD) of each variable and used the cutoff of ±0.3 to identify each cluster’s key features. We assessed the association of the phenotypes with multiple clinical endpoints using logistic regression (LR) analysis.Results: The consensus cluster analysis identified two clusters (Cluster 1: n=9,848; Cluster 2: n=12,077). The key features of patients in Cluster 1, compared with Cluster 2, included: lower blood pressure, lower eGFR (estimated glomerular filtration rate), higher BUN (blood urea nitrogen), higher creatinine, lower albumin, higher potassium, lower bicarbonate, lower red blood cell (RBC), higher red blood cell distribution width (RDW), higher SOFA score, higher APS III score, and higher APACHE IV score on admission. The results of LR analysis showed that the Cluster 2 was associated with lower in-hospital mortality (odds ratio [OR]: 0.374; 95% confidence interval [CI]: 0.347-0.402; P < 0.001), ICU mortality (OR: 0.349; 95% CI: 0.318-0.382; P < 0.001), and the incidence of acute kidney injury (AKI) after admission (OR: 0.478; 95% CI: 0.452-0.505; P < 0.001).Conclusions: ML consensus clustering analysis synthesized the pattern of clinical and laboratory data to reveal distinct CS phenotypes with different clinical outcomes.
The effect of GDP, renewable energy and total energy supply on carbon emissions in the EU-27: New evidence from panel GMM
Authors: Deka Abraham , Ozdese Huseyin , Seraj Mehdi
Published: May 2022

The vast usage of sources of energy that pollute the environment has caused major problems of global warming in the world. Global warming and greenhouse effect causes droughts, hunger and starvation among many other health problems. In this research the effect of energy use, economic, growth and renewable energy on carbon emissions in the European Union region from 1990–2019 is examined. The current study differs from previous researches done in this region, in that it specifies in the model “effective capital”, which is the interaction between energy and capital (a product of energy and capital). Effective capital is inevitable in the production process, because physical capital such as machinery, without power or energy to fuel it, is dysfunctional. The current research employs the Generalized Method of Moments which is strong over endogeneity and overcomes heteroskedasticity, serial and autocorrelation problems for robust results. The findings of this research support past studies that renewable energy reduces carbon emissions and Gross Domestic Product exacerbates carbon emissions. Effective capital and energy use are observed to promote carbon emissions, whereas capital and population size reduces carbon emissions in the European Union.
Epidemiology and Outcomes of Culture-Positive Bloodstream Pathogens Prior to and During the SARS-CoV-2 Pandemic: A Multicenter Evaluation
Authors: Bauer Karri A. , Puzniak Laura A. , Yu Kalvin , Finelli Lyn , Moise Pamela , Ai ChinEn , Watts Janet A. , Gupta Vikas
Published: May 2022

Background
Bloodstream infections (BSIs) are an important cause of morbidity and mortality in hospitalized patients. We evaluate incidence of community- and hospital-onset BSI rates and outcomes before and during the SARS-CoV-2 pandemic.
Methods
We conducted a retrospective cohort study that evaluated patients who were hospitalized for ≥ 1 day with discharge or death between June 1, 2019, and September 4, 2021 across 271 US health care facilities. Community- and hospital-onset BSI and related outcomes before and during the SARS-CoV-2 pandemic, including intensive care admission rates, and overall and ICU-specific length of stay (LOS) was evaluated. Bivariate correlations were calculated between the pre-pandemic and pandemic periods overall and by SARS-CoV-2 testing status.
Results
Of 5,239,692 patient admissions, there were 20,113 community-onset BSIs before the pandemic (11.2/1000 admissions) and 39,740 (11.5/1000 admissions) during the pandemic (P ≤ 0.0062). Corresponding rates of hospital-onset BSI were 2,771 (1.6/1000 admissions) and 6,864 (2.0/1000 admissions; P < 0.0062). Compared to the pre-pandemic period, rates of community-onset BSI were higher in patients who tested negative for SARS-CoV-2 (15.8/1000 admissions), compared with 9.6/1000 BSI admissions among SARS-CoV-2–positive patients. Compared with patients in the pre-pandemic period, SARS-CoV-2–positive patients with community-onset BSI experienced greater ICU admission rates (36.6% vs 32.8%; P < 0.01), greater ventilator use (10.7% vs 4.7%; P < 0.001), and longer LOS (12.2 d vs 9.1 d; P < 0.001). Rates of hospital-onset BSI were higher in the pandemic period vs the pre-pandemic period (2.0 vs 1.5/1000; P < 0.001), with rates as high a 7.3/1000 admissions among SARS-CoV-2–positive patients. Compared to the pre-pandemic period, SARS-CoV-2–positive patients with hospital-onset BSI had higher rates of ICU admission (72.9% vs 55.4%; P < 0.001), LOS (34.8 d vs 25.5 d; P < 0.001), and ventilator use (52.9% vs 21.5%; P < 0.001). Enterococcus species, Staphylococcus aureus, Klebsiella pneumoniae, and Candida albicans were more frequently detected in the pandemic period.
Conclusions and Relevance:
This nationally representative study found an increased risk of both community-onset and hospital-onset BSI during the SARS-CoV-2 pandemic period, with the largest increased risk in hospital-onset BSI among SARS-CoV-2-positive patients. SARS-CoV-2 positivity also was associated with worse outcomes.
Self-biting behavior in patients with neonatal brachial plexus palsy
Authors: Heise Carlos Otto , Zaccariotto Monise , Martins Roberto S. , Sterman-Neto Hugo , Siqueira Mário G.
Published: May 2022

Purpose: Self-biting behavior in patients with neonatal brachial plexus palsy (NBPP) has been associated with finger amputation. Our objective is to describe the incidence of this complication, risk factors, and clinical management.Methods: We retrospectively analyzed 612 patients with NBPP. There were 303 males and 309 females. 51.8% of patients had C5-C6 lesions, 28.9% had C5-C7, 18.9% had C5-T1, and 0.3 had C7-T1 involvement.Results: We identified 15 patients with self-biting behavior (2.5%). Ten patients had C5-T1 lesions, and five had C5-C7 lesions. Eight patents were submitted to brachial plexus surgery and seven were not. This behavior appeared between 8 and 46 months of life (mean 23.5), and it was always temporary. There was no difference between operated and non-operated patients (p > 0.05), and no correlation between age at surgery and age of appearance of self-biting behavior (p > 0.05). Physical restriction was effective in treating this complication and we had no case of finger amputation.Conclusion: Self-biting behavior is a rare complication of NBPP, and it is usually associated with severe motor involvement. The behavior duration is limited to a few months. This condition can be effectively treated with physical restriction to prevent hand biting.
Poly (ADP-ribose) polymerases 16 triggers pathological cardiac hypertrophy via activating IRE1α-sXBP1-GATA4 pathway
Authors: Su Haibi , Xu Jie , Su Zhenghua , Xiao Chenxi , Wang Jinghuan , Zhong Wen , Meng Chen , Yang Di , Zhu Yizhun
Published: May 2022

Background: Pressure overload-induced pathological cardiac hypertrophy is an independent predecessor of heart failure (HF), which remains the leading cause of worldwide mortality. However, current evidence on the molecular determinants of pathological cardiac hypertrophy is still inadequacy. This study aims to elucidate the role and mechanisms of Poly (ADP-ribose) polymerases 16 (PARP16) in the pathogenesis of pathological cardiac hypertrophy. Methods: Gain and loss of function approaches were used to demonstrate the effects of genetic overexpression or deletion of PARP16 on cardiomyocyte hypertrophic growth in vitro . Ablation of PARP16 by transducing the myocardium with adeno-associated virus 9 (AAV9)encoding PARP16 shRNA were then subjected to transverse aortic construction (TAC) to investigate the effect of PARP16 on pathological cardiac hypertrophy in vivo . Coimmunoprecipitation (IP) and western blot assays were used to detect the mechanisms of PARP16 in regulating cardiac hypertrophic development. Results: PARP16 deficiency rescued cardiac dysfunction and ameliorated TAC-induced cardiac hypertrophy and fibrosis in vivo , as well as phenylephrine (PE)-induced cardiomyocyte hypertrophic responses in vitro . Whereas overexpression of PARP16 exacerbated hypertrophic responses including the augmented cardiomyocyte surface area and upregulation of the fetal gene expressions. Mechanistically, PARP16 interacted with and ADP-ribosylated IRE1α and then mediated the hypertrophic responses through activating the IRE1α-sXBP1-GATA4 pathway. Conclusions: Collectively, our results implicated that PARP16 is a contributor of pathological cardiac hypertrophy at least in part via activating the IRE 1α -sXBP1-GATA4 pathway, and may be regarded as a new potential target for exploring effective therapeutic interventions of pathological cardiac hypertrophy and heart failure.
The Influence of Pacific-North American Teleconnection on the North Pacific SST Anomalies in Wintertime under the Global Warming
Authors: Chen Zheng , Gan Bolan , Huang Fei , Li Jianping , Wu Lixin , Fan Lei , Diao Yina
Published: May 2022

The impact of the enhancing Pacific-North American teleconnection (PNA) on the intensity of the first mode of SST anomalies (SSTa) in wintertime North Pacific [known as the Pacific decadal oscillation (PDO)-like SST pattern] under global warming is studied using reanalysis datasets and 12 selected CMIP5 models. The robust observational result of the PNA one month ahead of the PDO shows that the PNA has a great effect on the PDO-like SSTa. The intensities of PNA and PDO are defined with elimination of ENSO effect to evaluate the direct impact of PNA on the PDO in North Pacific under global warming. By comparing RCP8.5 and historical scenario of selected multi-models (PNA enhanced models), future projection illustrates that the PDO intensity will intensify 2.2 times its internal variability. Approximately 67% of the increase in PDO variations is contributed by the PNA-induced SSTa in the future warming scenario of multi-models ensemble mean. Models with stronger intensification of PNA variability tends to have larger magnitude of SSTa response in the North Pacific, which has more contributions to the enhancement of PDO intensity change in a warmer climate. This may shed some light on the projection of PDO variability and the relative role of PNA forcing under the global warming.
Economic Policy Uncertainty and Pandemic Uncertainty impacts on Tunisian sectors stock returns: evidence from VAR-DCC-GARCH model
Authors: GUENICHI Hassan , Nejib CHOUAIBI
Published: May 2022

To examine the effects of economic policy uncertainty (EPU) and pandemic uncertainty (PU) on Tunisian sectorial stock market returns, our paper contributes to the financial literature by providing a new study based on VAR-DCC-GARCH. This study uses the EPU and pandemic uncertainty indices and daily of eight Tunisian sector indices namely Automobile and Parts (AP), Banks, Basic Materials (BM), Building Construct Materials (BCM), Financials (FIN), Industrials (IND), Insurance (INS) and Food and Beverage (FB). The symmetric VAR-DCC-GJR-GARCH and VAR-DCC-EGARCH are the appropriate model for the empirical study. Results show a mixed sign of time varying correlation of sectors returns with EPU with respectively high and low significant long run and short run persistence of shocks. Evidence suggests that PU starts with a tranquil correlation and then becomes negative indicating the negative effect on sectors returns. In the last half of 2021, Tunisian investors succeed to overcome their fear and less risk averse.Jel codes : C32 ; D53 ; D74 ; G38 ; H12.
Impact of Social and Cultural Factors on Incidence, Transmission and Control of Coronavirus Disease in Iran: A Qualitative Study
Authors: Falla-Aliabadi Saeed , Heydari Ahad , Fatemi Farin , Yoshany Nooshin , Lotfi Mohammad Hasan , Sarsangi Alireza , Hanna Fahad
Published: May 2022

Introduction: COVID-19 pandemic has had mixed reactions from nations, people and governments about ways to cope with, prevent and control the disease. The current study identifies social, cultural and policy factors affecting the incidence and control of Coronavirus disease in Iran.Methods: A qualitative study consists of content analysis and views of experienced and knowledgeable subjects specialized in social and cultural health management. Data collection has been implemented through appropriate content specific search as well as semi-structured interviews. Data analysis was complemented by inductive content analysis. Results: There are distinct social and cultural factors in coping with Coronavirus disease. These consisted of three categories of governance, individual and community related factors. A total of 21 subcategories and 215 primary codes that were extracted from the text of interviews as variables of the study and in relation to the research question. Twelve subdomains of governance including vaccination, political factors, restrictions, education, support services, administrative services, transportation, health and treatment, culturalization, legislation, management and finance impacted the spread and mitigation of the pandemic at various levels. Conclusion: The management of pandemics requires a comprehensive capacity for identifying and determining social and cultural criteria. A healthy partnership between governments and the community may be required to remove unnecessary obstacles that hinder public health attempt to alleviate the risk. The obtained criteria and indicators from this study may be utilized by policy makers in an attempt to strengthen protocols for mitigating pandemics. Further studies may be warranted to confirm these findings
Non-pharmaceutical interventions and risk of COVID-19 infection: survey of U.K. public from November 2020 – May 2021
Authors: Francis Nick A , Becque Taeko , Willcox Merlin , Hay Alastair , Lown Mark , Clarke Richard , Stuart Beth , Yardley Lucy , Moore Michael , Houriet Joëll , Little Paul
Published: May 2022

Introduction:Non-pharmaceutical interventions (NPIs), such as handwashing, social distancing and face mask wearing, have been widely promoted to reduce the spread of COVID-19. This study aimed to explore the relationship between self-reported use of NPIs and COVID-19 infection.Methods:We conducted an online questionnaire study recruiting members of the U.K. public from November 2020 to May 2021. The association between self-reported COVID-19 illness and reported use of NPIs was explored using logistic regression and controlling for participant characteristics, month of questionnaire completion, and vaccine status. Participants who had been exposed to COVID-19 in their household in the previous 2 weeks were excluded.Results:27,758 participants were included and 2,814 (10.1%) reported having had a COVID-19 infection. The odds of COVID-19 infection were reduced with use of a face covering (OR 0.16 (95% CI: 0.12 to 0.21) and per increase in level of use (never, sometimes, quite often, very often, always) in unadjusted (OR 0.74 (95% CI: 0.72 to 0.77)) and fully adjusted analyses (OR 0.66 (95% CI: 0.62 to 0.71)). COVID-19 infection was also reduced with use of social distancing (OR 0.57 (95% CI: 0.41 to 0.80)) and per increase in level of use in unadjusted (OR 0.77 (95% CI:0.74 to 0.80) but not fully adjusted (OR 0.96 (95% CI: 0.90 to 1.03)) analyses. Greater use of handwashing when arriving home was associated with reduced odds of infection (OR 0.75 (0.69 to 0.81) per increase in level, fully adjusted), but handwashing before eating, avoiding touching the face, and cleaning things with virus on were not. Being in crowded places of 10-100 people and >100 people was associated with increased odds of COVID-19 infection compared to no attendance (OR 1.39 (95% CI: 1.17 to 1.66) and 1.42 (95% CI: 1.20 to 1.68), respectively).Conclusions:We found good evidence that use of face coverings and social distancing (including avoiding crowded places) reduced the odds of COVID-19 infection. We also found good evidence for a protective effect from handwashing on arriving home, but no evidence of benefit from handwashing before eating or other behaviours.
Low cost, environmentally friendly and high-performance cellulose-based triboelectric nanogenerator for self-powered human motion monitoring
Authors: Zhu Qiuxiao , Wang Tingting , Wei Yuhe , Sun Xiaoping , Zhang Sheng , Wang Xuchong , Luo Lianxin
Published: May 2022

Cellulose-based triboelectric nanogenerators (TENGs) can provide power for various monitoring devices and are environmentally friendly and sustainable. Chemical functional modification is a common method to improve the electrical output performance of cellulose-based TENGs. In this work, an environmentally friendly high-performance triboelectric nanogenerator based on polydopamine/cellulose nanofibrils (PDA/CNF) composite membrane and fluorinated ethylene propylene (FEP) was developed. Dopamine generates polydopamine nanoparticles through oxidative self-polymerization and adheres to the surface of nanofibers. The synergistic effect of amino group introduction and membrane surface microstructure has effectively enhanced the output performance of TENG to a certain extent.The effects of contentration of PDA, thickness of CNF composite film and different working conditions on the electrical output were systematically investigated.The optimized PDA/CNF-TENG exhibited an enhanced electrical output performance with the voltage, current, and power density values of ≈ 205 V, ≈ 20 µA, and ≈ 56.25 µW·cm− 2, respectively. The PDA/CNF-TENG exhibited stable and identifiable signals when used as a self-powered sensor for human motion monitoring, showing the potential prospects of cellulose materials for TENG and other electronic applications.
Clinical, Radiological and Genetic Variation In Pontocerebellar Hypoplasia Disorder & Our Clinical Experience
Authors: bilge serap , Mert Gülen Gül , Hergüner Özlem , Özcanyüz Duygu , Bozdoğan Sevcan Tuğ , Kaya Ömer , Havalı Cengiz
Published: May 2022

Background Pontocerebellar hypoplasia (PCH) constitutes a heterogeneous neurodegenerative/neurodevelopmental disorder of the pons and cerebellum with onset in the prenatal period. Our study aimed to present different clinical and radiological manifestations of our genetically diagnosed PCH patientsMaterial & Methods Six patients were enrolled in this study from September 2018 to March 2021. All the clinical radiological and genetic investigations were done at Cukurova University Medical School.Results Five children were diagnosed genetically and categorized under one of the types of PCH (type 10,7,11). Homozygous mutaion in CLP1In PCH type 10, TOE1 in PCH type 7 and TBC1D23 in PCH type 11 were respectively detected. At the same time, one patient was genetically diagnosed with cerebellofaciodental syndrome (BRF1) gene but was not categorized under one of the types of PCH. Conclusion According to our study, PCH is a rare neurodegenerative disease, although some types are static as PCH11 male gender and PCH7 female gender. Some clinical features are specific to a definite type. PCH7 express disorders of sex development most apparent in 46 XY. Some ethnic groups could express distinct subtypes. PCH10 is seen in the Turkish population. Radiological imaging is beneficial in pre-diagnosis; all the patients had different pons and cerebellar hypoplasia degrees. Genetic testing as like whole exome sequencing via next-generation sequencing is essential in setting the definite diagnosis and determining the type/subtype of PCH. Phenobarbital is effective as a symptomatic treatment of seizures in PCH.
Effects of the ketogenic diet in mice with hind limb ischemia
Authors: Shalamu Adilan , Dong Zhen , Liu Bowen , Pan Lihong , Cai Yun , Ma Xiurui , Hu Kai , Sun Aijun , Ge Junbo
Published: May 2022

Purpose
The ketogenic diet (KD) has anti-tumor and anti-diabetic effects in addition to its anti-epileptic role. It could also improve cardiac function and attenuate neurological insult. However, the effect of the KD on blood flow or tissue recovery after ischemia remains largely unknown. Thus, we observed blood flow and ischemic tissue recovery following hind limb ischemia in mice.
Methods
C57 mice were fed with either a KD or normal diet (ND) for 2 weeks, before inducing hind limb ischemia, blood perfusion of ischemic limb tissue was observed at 0, 7, and 21 days post operation.
Results
KD not only decreased blood perfusion of ischemic limb tissue but also delayed muscle recovery after ischemia, induced muscle atrophy of non-ischemic tissue compared to mice fed with ND. Furthermore, KD delayed wound healing at the surgical site and aggravated inflammation of the ischemic tissue. At the cellular level, KD altered the metabolic status of limb tissue by decreasing glucose and ketone body utilization while increasing fatty acid oxidation. Following ischemia, glycolysis, ketolysis, and fatty acid utilization in limb tissue were all further reduced by KD, while ketogenesis was mildly increased post KD in this mice model.
Conclusion
KD may delay tissue recovery after ischemia and induce more muscle atrophy in non-ischemic tissue. Our results hint that patients with limb ischemia should avoid ketogenic diet.