bluuebunny/crossref_metadata_2025 huggingface dataset:
СТРАТЕГІЧНИЙ АНАЛІЗ КОНКУРЕНТНОГО СЕРЕДОВИЩА НА РИНКУ ОРГАНІЧНОЇ ПРОДУКЦІЇ УКРАЇНИ
Authors: Журило Вікторія , Шаталова Лілія
Published: March 2022

Статтю присвячено стратегічному аналізу конкурентного середовища на ринку органічної продукції України. Підкреслено, що в умовах загострення екологічних проблем, спричинених господарською діяльністю людини, підвищується рівень екосвідомості споживачів, спостерігаються трансформації ринкової поведінки сучасного споживача, якій під впливом поширення тренду ведення здорового способу життя стає більш вимогливим до якості та способу виробництва продуктів харчування. Визначено та систематизовано фактори бізнес-середовища, що впливають на розвиток ринку органіки в Україні та діяльність господарюючих суб’єктів. Досліджено конкурентний стан галузі органічного виробництва та охарактеризовано бар’єри входження до неї із застосуванням інструментів стратегічного аналізу. На основі побудови карти стратегічних груп конкурентів визначено підприємства, які займають близькі позиції на ринку та конкурують у межах визначеної стратегічної групи із застосуванням однакових конкурентних критеріїв. Виявлено чинники забезпечення конкурентоспроможності компанії, охарактеризовано товарні сегменти та визначено їх ринкову привабливість.
РЕФРАКЦІЯ МІКРОЕКОНОМІЧНИХ, МАКРОЕКОНОМІЧНИХ ТА МІЖНАРОДНИХ ЗРІЗІВ ІННОВАЦІЙНИХ СТРАТЕГІЙ ЕКОНОМІЧНОЇ ДІЯЛЬНОСТІ В КОНТЕКСТІ ТВОРЧОСТІ В. ШЕКСПІРА
Authors: Білоцерківець Володимир , Завгородня Олена
Published: March 2022

Стаття присвячена дослідженню особливостей рефракції у творчості Вільяма Шекспіра мікроекономічних та макроекономічних аспектів економічної діяльності. Проаналізовано специфіку соціально-економічного тла формування Вільяма Шекспіра як митця та особистості, визначено роль пандемії чуми у метаморфозах економічного та соціального буття зрілого Середньовіччя. Розкрито засади та специфіку реалізації інноваційних стратегій розвитку, що набувають поширення в Європі на зрізі Середньовіччя та Нового часу. Показано причини та особливості трансформацій міжнародних логістичних ланцюжків, проведено аналіз впливу на діяльність середньоземноморських негоціантів виходу торгівлі за регіональні рамки та набуття нею світового характеру, досліджено модальність відображення та інтерпретації змін в міжнародній економічній діяльності в творчості англійського поета.
АКЦИЗНЕ ОПОДАТКУВАННЯ МІЦНИХ АЛКОГОЛЬНИХ НАПОЇВ
Authors: Бойко Світлана , Кулинич Юрій , Корнієнко Марія
Published: March 2022

Стаття присвячена проблематиці акцизного оподаткування міцних алкогольних напоїв. У статті досліджено особливості реалізації фіскального та регуляторного ефекту акцизного податку у частині оподаткування міцних алкогольних напоїв. Визначено часткову втрату фіскального ефекту акцизного оподаткування міцних алкогольних напоїв через відмову від підвищення (індексації) ставок акцизних податків у частині оподаткування міцних алкогольних напоїв у 2018-2021 рр. Побудовано регресійні багатофакторні моделі надходжень акцизного податку від оподаткування виноробної продукції та лікеро-горілчаної продукції. Оцінено регуляторний ефект акцизного оподаткування із застосуванням кореляційного аналізу ставок акцизного податку та соціально-економічних показників. Зроблено висновок, що індексація ставок акцизного податку у частині оподаткування міцних алкогольних напоїв у 2022 р. потенційно повинна мати наслідком збільшення надходжень акцизного податку до державного бюджету, а також посилення регуляторного ефекту через подальше зменшення кількості ДТП та їх наслідків при керуванні у нетверезому стані або перебуванні пішоходів у нетверезому стані.
НОВЕ ЕКОНОМІЧНЕ РАБСТВО У ПРАКТИЦІ СУЧАСНИХ КОМПАНІЙ ТА ПРОТИДІЯ ЙОМУ В РАМКАХ СОЦІАЛЬНОЇ ВІДПОВІДАЛЬНОСТІ БІЗНЕСУ
Authors: Дзюба Оксана , Левіщенко Олена , Величко Аліна
Published: March 2022

Стаття розглядає актуальне питання діяльності соціально відповідального бізнесу в рамках захисту прав людини. А саме у частині протидії торгівлі людьми і економічному рабству відповідно до принципу Глобального договору ООН щодо того, що ділові кола не повинні бути причетні до порушень прав людини. Було показано, що сучасна торгівля людьми має економічне підґрунтя і широкий спектр форм, які чітко описані у міжнародних та національних нормативних актах. Було обґрунтовано доцільність визначення економічного рабства як форми порушення прав людини. На основі цього було проаналізовано складові економічного рабства та вигоди, які від такої організації роботи отримує соціально безвідповідальне підприємство. Це було розглянуто на прикладі міжнародної компанії Glovo та надано рекомендації по протидії економічному рабству компаній із аналогічною поведінкою на ринку праці.
ПОКАЗНИКИ ОЦІНКИ СОЦІАЛЬНО-ЕОНОМІЧНОЇ ЕФЕКТИВНОСТІ ІНВЕСТУВАННЯ У ЛЮДСЬКИЙ КАПІТАЛ ПІДПРИЄМСТВА
Authors: Козюк Віктор , Шкодич Юлія
Published: March 2022

Актуальність дослідження обумовлена залежністю прогресу цивілізації від людського інтелекту та освітнього потенціалу. Сучасне виробництво стає все більш інтелектуальним, глобальна конкуренція зі сфери економіки переходить на освіту, науку, культуру та виховання. Саме тому знання, здібності та професіоналізм працівників відіграють вкрай важливу роль у зміцненні інновацій, підвищенні конкурентоспроможності компаній, ринкової вартості та прибутковості, а також визначенні перспектив подальшого динамічного зростання та економічного розвитку країни. Метою дослідження є згрупування показників соціально-економічної ефективності інвестування у людський капітал та формування груп індикаторів оцінки отриманого результату. Для досягнення мети та вирішення поставлених завдань використані такі загальнонаукові та спеціальні методи: теоретичного узагальнення – для визначення сутності та розвитку поняття інтелектуального капіталу та формування висновків; порівняльного аналізу – для дослідження тенденцій та перспектив розвитку професійного навчання, розвитку поглядів на процес інвестування в інтелект в контексті економічної науки. Головна увага акцентується на необхідності вкладення коштів у розвиток інтелекту працівників підприємств, відстеженню економічного змісту даного поняття у ретроспективі, що дає можливість прослідкувати вагомість цього процесу. Базуючись на результатах дослідження, нами згруповано показники оцінки соціально-економічної ефективності інвестування підприємством у людський капітал та визначено індикатори інтенсивності інвестування.
ОРГАНІЗАЦІЯ ОБЛІКУ ТА МЕТОДИЧНІ ЗАСАДИ ПРОВЕДЕННЯ АУДИТУ РОЗРАХУНКІВ З ПОСТАЧАЛЬНИКАМИ ТА ПІДРЯДНИКАМИ
Authors: Руда Лілія , Причепа Ірина , Липецька Олена
Published: March 2022

У статті досліджено особливості організації обліку та методичні засади аудиту розрахунків з постачальниками та підрядниками на вітчизняних підприємствах. Обґрунтовано необхідність подальших досліджень в сфері обліку та аудиту розрахунків з постачальниками та підрядниками. Висвітлено основні проблеми в організації обліку розрахунків з постачальниками та підрядниками на підприємстві. Визначено мету, основні завдання, інформаційне забезпечення, методичні засади аудиторської перевірки розрахунків з постачальниками та підрядниками та їх документальне забезпечення. Досліджено основні напрямки в господарській діяльності, що перевіряє аудитор в ході аудиторської перевірки операцій з контрагентами. Виокремлено типові помилки, що виявляють під час здійснення аудиторської перевірки операцій з постачальниками та підрядниками.
Study on the Integrated Development of Cinnamon Industry in Fangchenggang of Guangxi
Authors: Huang Guolin , Jiang Ligeng
Published: March 2022

SWOT analysis was adopted to analyze the integrated development of the cinnamon industry in the city of Fangchenggang. The integrated cinnamon industry in the city enjoys great advantages and opportunities, but there are also some problems in its development process, such as the low educational level of cinnamon farmers, weak driving ability and brand influence of leading enterprises, as well as the lack of a strong benefit coupling mechanism. To solve these problems, this paper puts forward several suggestions, such as extending the industrial chain to realize the integration of the primary, secondary and tertiary industries, attaching importance to brand building, optimizing the structure of practitioners, and strengthening the training of cinnamon farmers, optimizing a number of innovative regional enterprises that can lead the development of cinnamon industry and closely connects farmers, and improving the benefit coupling mechanism between farmers and enterprises.
Bayesian Approach: Adding Clinical Edge in Interpreting Medical Data
Authors: R.Vijayaragunathan  , John Kishore K , M.R.Srinivasan
Published: March 2022

In frequentist tests, the significance testing framework for null hypothesis permits dichotomous conclusions alone, and such tests do not quantify the strength of the evidence supporting the null hypothesis. Under the Bayesian approach, probability reflects their uncertainty or degree of belief, that is, how scientific belief should be modified by data. This paper attempts to demonstrate the advantages of the Bayes factor in hypothesis testing that can quantify evidence in favour of the null hypothesis and how the prior specification is used for statistical tools, such as independent t-test and Analysis of Variance (ANOVA). Despite the advantages of the Bayesian approach, the use of conventional tests that rely on inference by p-values is ubiquitous in medical research. The adoption of the Bayesian approach may be seriously hindered by the absence of formulae, algorithms, etc. Furthermore, we have attempted to validate our argument by interpreting the application of both the Frequentist and Bayesian approaches for dietary intake of calcium mg/day with the help of JASP software.
Indications of Actions by the Village Head in the Agency Perspective or Actor Reform Actions
Authors: Marsuki
Published: March 2022

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Copyright (c) 2019 Meraja journal
VIOLENCE IN HOUSEHOLD IN ISLAMIC LAW PERSPECTIVE
Authors: Guntur Rezky Try Ayunita , Ahmad Kamri , Bima Muh. Rinaldy
Published: March 2022

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OPTIMIZATION OF CRIMINAL ACTION OF CROSS-TRAFFIC ACCIDENTAL LAWS IN THE LAW REGION EAST LUWU POLRES
Authors: Sarifuddin  , Thalib Hambali , Pawennai Mulyati
Published: March 2022

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NATIONAL FUNCTION OF TERRORISM (BNPT) IN SOUTH SULAWESI
Authors: Musi Suci Ariska , Thalib Hambali , Mappaselleng Nur Fadhillah
Published: March 2022

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JUDICIAL REVIEW ON THE LOSS OF LAND OR CONFLICT OF LAND IN THE CRIMINAL LAW PERSPECTIVE
Authors: Gani Putra Ahmad , Thalib Hambali , Nawi Syahruddin
Published: March 2022

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INVESTIGATION OF CORRUPTION ON PROCUREMENT OF GOODS AND SERVICES (Study: Makassar District Attorney)
Authors: Annur Ahsan , Agis Abdul , Baharuddin Hamza
Published: March 2022

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LEGAL REVIEW OF WITHDRAWALS OF ROYALTIES BY COPYRIGHT MANAGEMENT INSTITUTIONS AND FOUNDATION OF COPYRIGHT INDONESIA BY ACCORDING TO LAW NUMBER 28 OF 2014 ON COPYRIGHT INSTITUTIONS
Authors: Anzani Ardil , Hafidz Ma’ruf , Khalid Hasbuddin
Published: March 2022

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THE EFFECTIVENESS OF THE REHABILITATION DECISION AGAINST VICTIMS OF NARCOTICS ABUSE IN MAKASSAR CITY
Authors: Arif Arfandi , Thalib Hambali , Badaru Baharuddin
Published: March 2022

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DISMISSAL (IMPEACHMENT) OF THE PRESIDENT AND / OR VICE PRESIDENT ACCORDING TO THE 1945 CONSTITUTION OF THE REPUBLIC OF INDONESIA
Authors: Ibrahim Fahmi , Husen La Ode , Razak Askari
Published: March 2022

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DEVELOPMENT STRATEGY OF COASTAL COASTAL AREA AS A TOURISM OBJECT IN BARRU DISTRICT
Authors: Muhammad Mukmin
Published: March 2022

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THE LEGAL PROTECTION FOR CHILDREN AS VICTIMS OF CRIMES OF THE SEXUAL VIOLENCE IN MAKASSAR CITY
Authors: Herman Nurfadillah , Thalib Hambali , Qahar Abdul
Published: March 2022

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LEGAL PROTECTION FOR WORKERS IN SPECIFIC TIME WORKING AGREEMENTS (PKWT) IN INDOLIMA PERKASA
Authors: Sari Rifani Anindhika , Baharuddin Hamza , Zainuddin
Published: March 2022

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POLYGAMY IN THE INDONESIAN MARRIAGE LAW SYSTEM
Authors: Rizki Sri , Rahman Sufirman , Sampara Said
Published: March 2022

Abstract

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THE IMPLEMENTATION OF THE FUNCTION OF THE LAND OFFICE IN RESOLVING LAND DISPUTES THROUGH MEDIATION
Authors: indiyarti.S Chilsy , Nawi Syahruddin , Abbas Ilham
Published: March 2022

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IMPLEMENTATION OF DIVERSION ON CHILDREN WHO ABUSE ABUSE IN MAKASSAR CITY
Authors: Fisiko Dewi Damaryanti , Thalib Hambali , Baharuddin Hamza
Published: March 2022

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IMPLEMENTATION OF THE POPULATION ADMINISTRATIVE INFORMATION SYSTEM (SIAK) IN IMPROVING PUBLIC SERVICES
Authors: Jumria
Published: March 2022

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IMPLEMENTATION OF THE DPRD SUPERVISORY FUNCTION ON THE IMPLEMENTATION OF THE PANGKEP DISTRICT APBD IN 2019
Authors: A. Abidin Anshar , Hasanah Nur
Published: March 2022

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IMPLEMENTASI KEBIJAKAN PEMERINTAH TENTANG BOARDING SCHOOL DI SMA NEGERI 6 BARRU KABUPATEN BARRU
Authors: Muliati  , Asyah Idrus Nur
Published: March 2022

Copyright (c) 2021 Meraja journal
IMPLEMENTATION OF GENDER EQUALITY IN SUMPANG BINANGAE SUB-DISTRICT, BARRU DISTRICT
Authors: Asriani  , Pebrianti Fitra
Published: March 2022

Copyright (c) 2021 Meraja journal
VILLAGE FUND ALLOCATION PLANNING MODEL IN INFRASTRUCTURE DEVELOPMENT IN PATTAPPA VILLAGE, PUJANANTING DISTRICT, BARRU REGENCY
Authors: Masyitah  , Firdaus
Published: March 2022

Copyright (c) 2021 Meraja journal
ANALYSIS OF FACILITIES AND INFRASTRUCTURE MANAGEMENT IN SMPN SATAP 4 BARRU SCHOOL
Authors: Hasan Suriyati , Sumarni
Published: March 2022

Copyright (c) 2021 Meraja journal
IMPLEMENTATION OF RELATIONSHIP PATTERNS WITH THE VILLAGE CONSULTANCY BOARD (BPD) AND THE VILLAGE GOVERNMENT IN LALABATA VILLAGE, TANATE RILAU DISTRICT, BARRU REGENCY
Authors: Aidah Hj. , Salmawati
Published: March 2022

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QUALITY OF ADMINISTRATIVE SERVICE POPULATION IN IMPROVING PUBLIC SERVICES BASED ON KEPMEN NO. 25 OF 2004
Authors: Ariadi A.
Published: March 2022

This study aims to determine the quality of population administration services in terms of issuing Identity Cards in Lalolang Village based on the Decree of the Minister of Administrative Reform No. Kep/25/M.PAN/2/2004 dated February 24, 2004 concerning General Guidelines for Compiling the Community Satisfaction Index for Government Service Units. , and the factors that affect the quality of service for issuing Identity Cards in Lubtik Pakam III Sub-district, Lalolang District based on the Ministerial Decree No. 25 of 2004. This study uses a qualitative descriptive method with a case study approach with inductive data analysis techniques using a single table and then looking for the average service quality variable average. Collecting data using library research and field research. The population is the people of Lalolang Village totaling 4,656 people and the number is determined as a sample of 150 people from 9 (nine) neighborhoods, sampling using simple random sampling technique. Based on the results of data analysis, it is known that. The quality of population administration services in terms of issuing Resident Identity Cards in Lalolang Village based on the Decree of the Minister of Administrative Reform No. Kep/25/M.PAN/2/2004 dated February 24, 2004 concerning General Guidelines for Compiling the Community Satisfaction Index for Service Units of Government Agencies is included in the poor category . where from the 14 elements of service, there are 7 (seven) elements of service that are not good and 7 (seven) elements of service that are included in the good category, namely courtesy and friendliness of officers, certainty of service

schedules, environmental comfort. Based on the results of the research and the conclusions mentioned above, the authors contribute suggestions to improve aspects of knowledge where the real aspect is one of the requirements for improving the quality of human resources so that they can create human resources who are able to think ahead.
Internet of Things in E-Healthcare System
Authors: Sivarajan Varshni , Wai Leong Pang , Kah Yoong Chan , It Ee Lee , Gwo Chin Chung , Sew Kin Wong
Published: March 2022

Health awareness is important with increasingly complex challenges towards maintaining good health, especially during the COVID-19 pandemic. Regular health monitoring is a must for everyone during the pandemic. This project proposed an IoT based E-Healthcare system to monitor the body temperature, blood pressure and heartbeat rate. The temperature sensor was connected to a Raspberry Pi microcontroller and the readings were stored in the SQLite database management system. The blood pressure and heartbeat rate readings were retrieved from the wrist blood pressure sensor and the readings were entered into the database. The user can access the health data record through a smartphone.
The Impact of Covid-19 on Human Rescue Operations: A Review on Past Unmanned - Water Rescue Boats (U-Wrb) and Adopting Them to The New Norm
Authors: Nirmal Umar , Zulfakar Alif , Lau Tze Way Saijod , Megat Ahmad Mohd Megat Hamdan , Yaakob Mohd Yuhazri , Singh Jasspeed , Fairozan Mohd
Published: March 2022

Recently, the drowning cases of human beings are at an alarming rate. The current work presents a dedicated review on U-WRB for human rescue operations subjected to drowning. The review from year 1996 to 2018 highlights the key factors such as advantages and limitations of the developed U-WRB’s. Having completed the review, the work further proposes new research pathways that could be beneficial to the scientific community living in the new norm; COVID-19 where minimal contact between humans are of concern when it comes to human rescue operations. Possible new research pathways include but not limited to the type of sensors used, material selection, incorporation of state-of-the-art attachments to the U-WRB and customizable attachments to the main unit based on a given real time rescue operation are proposed.
Sustained attention in the elementary school classroom
Authors: Abtan Jamie
Published: March 2022

In this 10 minute video, the challenges of fostering sustained attention the elementary school classroom are discussed and practical classroom approaches are presented to support student growth and development.
Enhancing attention in the classroom
Authors: Cho Chen Ling
Published: March 2022

In this 10 minute video, the challenges of enhancing attention in the classroom are discussed and practical classroom approaches are presented to support student growth and development.
Urban Indigenous Second-Language Learning
Authors: Rafael Josha
Published: March 2022

As the language revitalization movement progresses, the impacts of Indigenous language beyond the domain of language use are gaining recognition. Previous literature has identified links between Indigenous language revitalization efforts and Indigenous well-being, but to date, there are few studies that explore this topic thoroughly. The purpose of this study is to explore the impacts of Indigenous second-language learning on urban Indigenous perceptions of their well-being. Urban Indigenous populations are growing, and are particularly impacted by language loss; thus, it is vital that urban perspectives be represented. Indigenous language-learners from the Nêhiyaw (Cree) Language Lessons Program in Edmonton, Alberta participated in semi-structured interviews. Five exploratory themes emerged from thematic analysis. The results presented in this paper, while exploratory, are a meaningful addition to the existing scholarship in this field. They may be used as a departure point for future research on the topic of Indigenous language learning and how it impacts Indigenous well-being.
Turning intimate spaces into digital classrooms: Public health students’ experiences of learning and doing critical qualitative research in pandemic times
Authors: Serota Kristie , Giles Madison , Kinitz David J
Published: March 2022

Throughout the COVID-19 pandemic, burgeoning health researchers have been tasked with learning how to conduct critical qualitative health research from the intimate spaces of their homes. In this presentation, we, three public health students, highlight our experiences as learners and doers of critical qualitative methods to demonstrate the challenges and triumphs that co-exist with pursuing our academic goals during a global pandemic. 
We employ a critical, reflexive narrative approach to storying our experiences of learning and practicing critical qualitative health research methods from the (dis)comfort of our homes during the pandemic. Using diverse theoretical lenses, including embodiment and poststructuralism, we story our experiences of navigating the blurry boundaries created by our necessary participation in the digital world. We construct and present these stories using arts-based qualitative research methods that were introduced to us in our courses and readings through the Centre for Critical Qualitative Health Research. Stitching together words to create poetry, fabric to construct a quilt, and pictures and writing to articulate experiences, these stories explore how the transformation of our intimate space into an academic and research space impacts the experience of learning to be a critical qualitative health researcher. David uses creative analytic writing practices through memos and journals, paired with photography, to express his experience as a learner. He draws on embodiment, attuning himself to the body to better understand his experiences. Through the medium of poetry, Madison grapples with the reality of being a digital student - letting her anxieties, curiosities, and questions stumble out to make sense of her virtual self. Finally, Kristie uses quilting to construct a material representation of the Zoom experience, exploring the intimacy and alienation of the digital classroom.
Through our stories, we hope to create space to deeply consider what it means to be an online learner and an online being. Through these three interwoven stories, we expose our vulnerabilities to carve out space to reflect on our needs and desires to thrive in digital learning environments.
Blended Learning as a Transformative Educational Approach for Qualitative Health Research
Authors: Arora Anish , Rice Kathleen , Adams Alayne
Published: March 2022

Background: Qualitative health research seeks to elucidate the realities of context, reveal the complexities of behaviour, probe the intersecting and multiple determinants of health at individual, community and institutional levels, and capture the dynamics of health care provision from the perspectives of patients, providers, and systems. Traditionally, in our Family Medicine Department at McGill University, graduate students are trained in qualitative health research in the context of a synchronous in-person classroom. Amidst the pandemic, synchronous learning shifted to online modalities, obliging rapid innovation in pedagogic practice. Careful consideration and creation of new online modalities for engaged student learning took place, and when implemented, instructor and student feedback was solicited on whether or how they were effective. Together, co-instructors and the teaching assistant for the course reflected on the challenges and opportunities of teaching qualitative research in an online environment, and how online modalities might be usefully blended with in-person learning.

Reflections: Three arguments supporting a blended approach were identified. Firstly, blending online and in-person approaches enables learners to tailor their educational experience to their needs and objectives, and to some extent, control the content, sequence, pace, and time of their learning. Secondly, blended learning empowers educators by offering tools and systems to monitor learner progress, while encouraging creativity in conveying content that may be complicated and dense (e.g., providing online workshops about managing qualitative data analysis via readily accessible online software). Lastly, blended learning has the potential to transform graduate training for the better by facilitating innovative modes of communication (e.g., use of chat function in videoconferencing software and online discussion boards as modalities for discussion that engage students who may not otherwise speak), enabling students to contextualize their projects (e.g., implementation of an observational data collection assignment, unique to each student based on where they live and their interests), while better balancing their academic, professional, and personal lives.

Discussion: To develop a thorough understanding of qualitative health research, key concepts can be taught and practiced through a combination of in-person and online synchronous and asynchronous learning modalities. In doing so, educators can take advantage of innovative learning technologies, while also maintaining the humanistic touch necessary for education to be meaningful and effective. Importantly, from our experiences we note that blended learning approaches are viable and pertinent in the context of qualitative health research, an idea that was previously dismissed due to perceptions that qualitative inquiry and learning requires solely in-person, hands-on, engagement.
Self-citation and its impact on scientific workflow assessment: The review of publications. Part I
Authors: Pislyakov V. V.
Published: March 2022

The author reviews publications on the problem of self-citation and resulting mispresentations at the stage bibliometric analysis. He introduces the definition of self-citation and its special cases, i. e. author’s, institutional, publisher’s and disciplinary. The formulas for general self-citation metrics, i. e. self-citation and self-citedness coefficients, are provided. The global publications on author’s, institutional, national and journal self-citation are reviewed thoroughly. The current concepts of the role and impact of self-citation on scientific activity assessment are generalized. On the basis of his analytical review, the author argues that the researchers obtain consensus on several aspects, e. g.: а) excessive and absent self-citation are both seen as pathologies; в) self-citation has insignificant impact on large research entities though this influence can be critical when analyzing contributions by individual authors; с) self-citation impact is well-expressed for scientific entities with weak bibliometric indicators, while the top scientists, organizations, journals, etc., get most of external links. The author examines the response of bibliometric indicators and databases to self-citation manipulations to adjust the indicators.

Part I of the review is intended to define the basic concepts and terms and to examine the most popular author’s self-citation.
La complessità della relazione medico-paziente in nefrologia: perché è ancora più importante occuparsene oggi?
Authors: Cara Marilena
Published: March 2022

Medicine is more than just a science: it is a human contact between men. We must not forget that “Psyche depends on the body and the body depends on the psyche”. The 21st Century man’s Psyche is more stressed than in the past, as we live in a complexity increasingly understood with the passage of time. The only way to take care of the sick person in the body, and therefore suffering in the psyche, can only be that which rests on the relationship, since the relationship, in my opinion, can be considered the bridge between the psyche and the soma. If the medical technique today does not pass through the relationship could it be effective in the cure? Trust in the doctor today is no longer a certainty, as medicine has lost its character of sacredness, but must be acquired and conquered through a dedicated and continuous relationship. Unlike other pathologies, nephrology does not end in a diagnosis or in a therapy that is provided at home, but the patient’s only point of reference is the nephrology nursing staff. Effective communication will lead to a reduction in the time taken for communication, improving the patient’s ability to understand and trust, reducing the operator’s effort and improving the therapeutic result. Today’s medicine, and today’s “healers” can no longer fail to deal with the management of the operator-patient relationship in order to meet the demands that today’s society and healthcare organization make in the medical field.
Определение аварийно-спасательных и других неотложных работ, выполняемых пожарной аварийно-спасательной службой гражданской обороны
Authors: Хроколов Виталий Александрович , Еремин Алексей Петрович
Published: March 2022

Цель. Определение видов аварийно-спасательных и других неотложных работ (далее – АСДНР), выполняемых пожарной аварийно-спасательной службой гражданской обороны Республики Беларусь (далее – ПАСС ГО) при ликвидации ЧС в военное время.
Методы. Общенаучные методы исследования: анализ и синтез, сравнение и обобщение.
Результаты. Определены виды АСДНР, выполняемые ПАСС ГО при ликвидации ЧС в военное время.
Область применения исследований. Результаты работы могут быть использованы при планировании мероприятий гражданской обороны.
Expression and Roles of Lynx1, a Modulator of Cholinergic Transmission, in Skeletal Muscles and Neuromuscular Junctions in Mice
Authors: Doss Sydney V. , Barbat-Artigas Sébastien , Lopes Mikayla , Pradhan Bhola Shankar , Prószyński Tomasz J. , Robitaille Richard , Valdez Gregorio
Published: March 2022

Lynx1 is a glycosylphosphatidylinositol (GPI)-linked protein shown to affect synaptic plasticity through modulation of nicotinic acetylcholine receptor (nAChR) subtypes in the brain. Because of this function and structural similarity to α-bungarotoxin, which binds muscle-specific nAChRs with high affinity, Lynx1 is a promising candidate for modulating nAChRs in skeletal muscles. However, little is known about the expression and roles of Lynx1 in skeletal muscles and neuromuscular junctions (NMJs). Here, we show that Lynx1 is expressed in skeletal muscles, increases during development, and concentrates at NMJs. We also demonstrate that Lynx1 interacts with muscle-specific nAChR subunits. Additionally, we present data indicating that Lynx1 deletion alters the response of skeletal muscles to cholinergic transmission and their contractile properties. Based on these findings, we asked if Lynx1 deletion affects developing and adult NMJs. Loss of Lynx1 had no effect on NMJs at postnatal day 9 (P9) and moderately increased their size at P21. Thus, Lynx1 plays a minor role in the structural development of NMJs. In 7- and 12-month-old mice lacking Lynx1, there is a marked increase in the incidence of NMJs with age- and disease-associated morphological alterations. The loss of Lynx1 also reduced the size of adult muscle fibers. Despite these effects, Lynx1 deletion did not alter the rate of NMJ reinnervation and stability following motor axon injury. These findings suggest that Lynx1 is not required during fast remodeling of the NMJ, as is the case during reformation following crushing of motor axons and development. Instead, these data indicate that the primary role of Lynx1 may be to maintain the structure and function of adult and aging NMJs.
Potential of Cellular Therapy for ALS: Current Strategies and Future Prospects
Authors: Lin Ting-Jung , Cheng Kuang-Chao , Wu Luo-Yun , Lai Wei-Yu , Ling Thai-Yen , Kuo Yung-Che , Huang Yen-Hua
Published: March 2022

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive upper and lower motor neuron (MN) degeneration with unclear pathology. The worldwide prevalence of ALS is approximately 4.42 per 100,000 populations, and death occurs within 3–5 years after diagnosis. However, no effective therapeutic modality for ALS is currently available. In recent years, cellular therapy has shown considerable therapeutic potential because it exerts immunomodulatory effects and protects the MN circuit. However, the safety and efficacy of cellular therapy in ALS are still under debate. In this review, we summarize the current progress in cellular therapy for ALS. The underlying mechanism, current clinical trials, and the pros and cons of cellular therapy using different types of cell are discussed. In addition, clinical studies of mesenchymal stem cells (MSCs) in ALS are highlighted. The summarized findings of this review can facilitate the future clinical application of precision medicine using cellular therapy in ALS.
A Unique Mechanochemical Redox Reaction Yielding Nanostructured Double Perovskite Sr2FeMoO6 With an Extraordinarily High Degree of Anti-Site Disorder
Authors: Tóthová Erika , Düvel André , Witte Ralf , Brand Richard A. , Sarkar Abhishek , Kruk Robert , Senna Mamoru , Da Silva Klebson Lucenildo , Menzel Dirk , Girman Vladimír , Hegedüs Michal , Baláž Matej , Makreski Petre , Kubuki Shiro , Kaňuchová Mária , Valíček Jan , Hahn Horst , Šepelák Vladimír
Published: March 2022

Strontium ferromolybdate, Sr2FeMoO6, is an important member of the family of double perovskites with the possible technological applications in the field of spintronics and solid oxide fuel cells. Its preparation via a multi-step ceramic route or various wet chemistry-based routes is notoriously difficult. The present work demonstrates that Sr2FeMoO6 can be mechanosynthesized at ambient temperature in air directly from its precursors (SrO, α-Fe, MoO3) in the form of nanostructured powders, without the need for solvents and/or calcination under controlled oxygen fugacity. The mechanically induced evolution of the Sr2FeMoO6 phase and the far-from-equilibrium structural state of the reaction product are systematically monitored with XRD and a variety of spectroscopic techniques including Raman spectroscopy, 57Fe Mössbauer spectroscopy, and X-ray photoelectron spectroscopy. The unique extensive oxidation of iron species (Fe0 → Fe3+) with simultaneous reduction of Mo cations (Mo6+ → Mo5+), occuring during the mechanosynthesis of Sr2FeMoO6, is attributed to the mechanically triggered formation of tiny metallic iron nanoparticles in superparamagnetic state with a large reaction surface and a high oxidation affinity, whose steady presence in the reaction mixture of the milled educts initiates/promotes the swift redox reaction. High-resolution transmission electron microscopy observations reveal that the mechanosynthesized Sr2FeMoO6, even after its moderate thermal treatment at 923 K for 30 min in air, exhibits the nanostructured nature with the average particle size of 21(4) nm. At the short-range scale, the nanostructure of the as-prepared Sr2FeMoO6 is characterized by both, the strongly distorted geometry of the constituent FeO6 octahedra and the extraordinarily high degree of anti-site disorder. The degree of anti-site disorder ASD = 0.5, derived independently from the present experimental XRD, Mössbauer, and SQUID magnetization data, corresponds to the completely random distribution of Fe3+ and Mo5+ cations over the sites of octahedral coordination provided by the double perovskite structure. Moreover, the fully anti-site disordered Sr2FeMoO6 nanoparticles exhibit superparamagnetism with the blocking temperature TB = 240 K and the deteriorated effective magnetic moment μ = 0.055 μB per formula unit.
Ethnicity-Specific Features of COVID-19 Among Arabs, Africans, South Asians, East Asians, and Caucasians in the United Arab Emirates
Authors: Al Zahmi Fatmah , Habuza Tetiana , Awawdeh Rasha , Elshekhali Hossam , Lee Martin , Salamin Nassim , Sajid Ruhina , Kiran Dhanya , Nihalani Sanjay , Smetanina Darya , Talako Tatsiana , Neidl-Van Gorkom Klaus , Zaki Nazar , Loney Tom , Statsenko Yauhen
Published: March 2022

Background

Dubai (United Arab Emirates; UAE) has a multi-national population which makes it exceptionally interesting study sample because of its unique demographic factors.

Objective

To stratify the risk factors for the multinational society of the UAE.

Methods

A retrospective chart review of 560 patients sequentially admitted to inpatient care with laboratory confirmed COVID-19 was conducted. We studied patients’ demographics, clinical features, laboratory results, disease severity, and outcomes. The parameters were compared across different ethnic groups using tree-based estimators to rank the ethnicity-specific disease features. We trained ML classification algorithms to build a model of ethnic specificity of COVID-19 based on clinical presentation and laboratory findings on admission.

Results

Out of 560 patients, 43.6% were South Asians, 26.4% Middle Easterns, 16.8% East Asians, 10.7% Caucasians, and 2.5% are under others. UAE nationals represented half of the Middle Eastern patients, and 13% of the entire cohort. Hypertension was the most common comorbidity in COVID-19 patients. Subjective complaint of fever and cough were the chief presenting symptoms. Two-thirds of the patients had either a mild disease or were asymptomatic. Only 20% of the entire cohort needed oxygen therapy, and 12% needed ICU admission. Forty patients (~7%) needed invasive ventilation and fifteen patients died (2.7%). We observed differences in disease severity among different ethnic groups. Caucasian or East-Asian COVID-19 patients tended to have a more severe disease despite a lower risk profile. In contrast to this, Middle Eastern COVID-19 patients had a higher risk factor profile, but they did not differ markedly in disease severity from the other ethnic groups. There was no noticeable difference between the Middle Eastern subethnicities—Arabs and Africans—in disease severity (p = 0.81). However, there were disparities in the SOFA score, D-dimer (p = 0.015), fibrinogen (p = 0.007), and background diseases (hypertension, p = 0.003; diabetes and smoking, p = 0.045) between the subethnicities.

Conclusion

We observed variations in disease severity among different ethnic groups. The high accuracy (average AUC = 0.9586) of the ethnicity classification model based on the laboratory and clinical findings suggests the presence of ethnic-specific disease features. Larger studies are needed to explore the role of ethnicity in COVID-19 disease features.
Do Probiotics Cause a Shift in the Microbiota of Dental Implants—A Systematic Review and Meta-Analysis
Authors: Sayardoust Shariel , Johansson Anders , Jönsson Daniel
Published: March 2022

Objective

The primary aim of this current systematic review and meta-analysis was to evaluate the potential microbiological effect of probiotics on the implant microbiota. The secondary aim was to evaluate if probiotics have any effect as an adjunct to non-surgical peri-implant treatment in reducing peri-implant mucositis and peri-implantitis clinical parameters—bleeding on probing, modified Gingival Index, and pocket depth.

Methods

The research focus questions were constructed in accordance with the Participants, Intervention, Comparison, and Outcomes (PICO) criteria, and a PROSPERO protocol was registered. A comprehensive systematic search in MEDLINE via the PubMed, Scopus, and Web of Science Core Collection databases was conducted. Two independent reviewers screened the reports based on the PICO criteria—inclusion and exclusion criteria.

Results

In total, 467 records were identified, and ultimately, 7 papers were included: 3 papers in the qualitative synthesis of microbiological effect and 4 in the meta-analysis synthesis on pocket depth. The data synthesis showed that probiotics had no detectable effect on the implant microflora, and in the following data synthesis, no clinical peri-implantitis variable showed a significantly beneficial effect from probiotics in the test group compared to the control group.

Conclusion

Within the limitations of this review, the oral implant microflora is not affected by probiotics nor do probiotics add any effect to the conventional non-surgical treatment of peri-implant mucositis and peri-implantitis.
Verification Data and the Skill of Decadal Predictions
Authors: Boer George J. , Sospedra-Alfonso Reinel , Martineau Patrick , Kharin Viatsheslav V.
Published: March 2022

The utility of a forecast depends on its skill as demonstrated by past performance. For most forecasts errors rapidly become large compared to uncertainties in the observation-based state of the system and, for this reason, it is usually deemed adequate to assess predictions against a single verification dataset. Eleven reanalyses and station-based analyses of annual mean surface air temperature are compared as are basic skill measures obtained when using them to verify decadal prediction hindcasts from the Canadian Centre for Climate Modelling and Analysis forecasting system. There are differences between reanalysis and station-based analyses which translate also into differences in basic skill scores. In an average sense, using station-based verification data results in somewhat better correlation skill. The spread between the locally best and worst scores is obtained for individual forecast ensemble members and for ensemble mean forecasts compared to individual analyses. The comparison of ensemble mean forecasts against different analyses can result in apparent skill differences, and using a “favorable” analysis for verification can improve apparent forecast skill. These differences may be more pertinent for longer time averages and should be considered when verifying decadal predictions and when comparing the skill of decadal prediction systems as part of a model intercomparison project. Either a particular analysis could be recommended by the decadal prediction community, if such could be agreed on, or the ensemble average of a subset of recent analyses could be used, assuming that ensemble averaging will act to average out errors.
Photo-Regulation of Enzyme Activity: The Inactivation of a Carboligase with Genetically Encoded Photosensitizer Fusion Tags
Authors: Gerlach Tim , Schain Jendrik , Söltl Simone , van Schie Morten M. C. H. , Hilgers Fabienne , Bitzenhofer Nora L. , Drepper Thomas , Rother Dörte
Published: March 2022

Genetically encoded photosensitizers are able to produce reactive oxygen species upon illumination and are exploited in a wide range of applications, especially in the medical field. In this work, we envisioned to further apply these genetically encoded photosensitizers for the light-dependent control of single enzymes in multi-step biocatalysis. One of the challenges in the application of several enzymes in a cascade is the unwanted cross-reactivity of these biocatalysts on reaction intermediates when all enzymes are simultaneously present in the reaction. As one strategy to address this issue, we investigated whether the introduction of genetically encoded photosensitizers as fusion tags would allow the selective inactivation of enzymes after successful transformation by simply turning on light. We tested five different photosensitizers as molecular biological fusion tags to inactivate the pyruvate decarboxylase variant E469G/W543H from Acetobacter pasteurianus. Dimeric photosensitizer tags, like the flavin-binding fluorescent proteins from Bacillus subtilis and Pseudomonas putida showed the tendency to form insoluble protein aggregates in combination with the tetrameric carboligase. Enzyme activity was, to some extent, retained in these aggregates, but the handling of the insoluble aggregates proved to be unfeasible. Monomeric photosensitizer tags appeared to be much more suitable when fused to the tetrameric enzyme. In the dark, the singlet oxygen photosensitizing protein (SOPP3)-tagged carboligase retained 79% of its activity as compared to the unfused enzyme. Upon blue light exposure, the SOPP3 tag showed the best specific inactivation and enabled complete inactivation of the carboligase within 30 min. SOPP3 is thus seen as a promising photosensitizer tag to be applied in future multi-step enzyme cascades to overcome the challenge of cross-reactivity.
Phenotypic Presentations of Heart Failure Among Patients With Chronic Inflammatory Diseases
Authors: Underberg Daniel L. , Rivera Adovich S. , Sinha Arjun , Feinstein Matthew J.
Published: March 2022

Objective

Characterize incident heart failure (HF) phenotypes among patients with various chronic inflammatory diseases (CIDs).

Background

Several CIDs are associated with increased HF risk, but differences in HF phenotypes across CIDs are incompletely understood. No prior studies to our knowledge have manually adjudicated HF phenotypes across a CID spectrum.

Methods

We screened for patients with—and controls without—CIDs who had possible HF, then hand-adjudicated HF endpoints. Possible HF resulted from a single HF administrative code; HF was deemed definite/probable vs. absent using standardized, validated criteria. We queried adjudicated HF patients' charts to define specific HF phenotypes, then compared clinical, demographic, and HF phenotypic characteristics for HF patients with specific CIDs vs. non-CID controls using Fisher's exact test.

Results

Out of 415 possible HF patients, 192 had definite/probable HF. Significant differences in HF phenotypes existed across CIDs. Isolated right-sided HF was present in 27.8% of patients with SSc and adjudicated HF, which is more than twice as common as it was in any other CID. Left ventricular systolic dysfunction was most common in patients with HIV and lupus (SLE); mean LVEF was 45.0% ± 18.6% for HIV and 41.3% ± 17.1% for SLE, but was 57.7% ± 10.7% for SSc. Those with HIV and multiple CIDs were most likely to have coronary artery disease.

Conclusions

Different CIDs present with different phenotypes of physician-adjudicated HF, potentially reflecting different underlying inflammatory pathophysiologies. Larger studies are needed to confirm these findings, as are mechanistic studies focused on understanding specific immunoregulatory contributors to HF.
Protective Value of Aspirin Loading Dose on Left Ventricular Remodeling After ST-Elevation Myocardial Infarction
Authors: Calvieri Camilla , Galea Nicola , Cilia Francesco , Pambianchi Giacomo , Mancuso Giuseppe , Filomena Domenico , Cimino Sara , Carbone Iacopo , Francone Marco , Agati Luciano , Catalano Carlo
Published: March 2022

Aims

Left ventricular (LV) remodeling after ST-elevation myocardial infarction (STEMI) is a complex process, defined as changes of LV volumes over time. CMR feature tracking analysis (CMR-FT) offers an accurate quantitative assessment of LV wall deformation and myocardial contractile function. This study aimed to evaluate the role of myocardial strain parameters in predicting LV remodeling and to investigate the effect of Aspirin (ASA) dose before primary coronary angioplasty (pPCI) on myocardial injury and early LV remodeling.

Methods and Results

Seventy-eight patients undergoing CMR, within 9 days from symptom onset and after 6 months, were enrolled in this cohort retrospective study. We divided the study population into three groups based on a revised Bullock's classification and we evaluated the role of baseline CMR features in predicting early LV remodeling. Regarding CMR strain analysis, worse global circumferential and longitudinal strain (GCS and GLS) values were associated with adverse LV remodeling. Patients were also divided based on pre-pPCI ASA dosage. Significant differences were detected in patients receiving ASA 500 mg dose before pPCI, which showed lower infarct size extent and better strain values compared to those treated with ASA 250 mg. The stepwise multivariate logistic regression analysis, adjusted for covariates, indicated that a 500 mg ASA dose remained an inverse independent predictor of early adverse LV remodeling.

Conclusion

GCS and GLS have high specificity to detect early LV adverse remodeling. We first reported a protective effect of ASA loading dose of 500 mg before pPCI on LV myocardial damage and in reducing early LV adverse remodeling.