bluuebunny/crossref_metadata_2025 huggingface dataset:
The Lead Paragraph is a Structural Element of the Article and a Self-contained Text
Authors: Lenkova Tatyana
Published: March 2023

The focus of the proposed article is the introduction, or the lead paragraph, as a necessary element of any media text today. Particular attention is paid to the analysis of the views of domestic and foreign media linguists and practicing journalists on the essence of the lead paragraph, its structure and classification principles. The lead paragraph is one of the first structural elements of a modern media text that a reader encounters on a newspaper page. Its task in two or three sentences is not only to interest the potential reader, but also to briefly inform him about the main content of the article. That is why the lead paragraph is considered an independent text within the text. The present study traces the development of the lead paragraph in a dynamic aspect: that is, from the moment it appeared in the middle of the 19th century to the present day. Behavioral analysis suggests that the lead paragraph is a complex branched system that should be analyzed within the framework of a general paradigm. The most attractive for perception by the target audience may be compact introductions, typical for the German and partly for the Russian press.
Synthesis of Documentary and Artistic Codes in Dave Eggers’ Story “The Monk of Mokha”
Authors: Osadchaya Tatyana , Lushnikova Galina
Published: March 2023

This article is devoted to the analysis of documentary fiction based on the material of the story “The Monk of Mokha” by a contemporary American writer Dave Eggers. The purpose of the study is to identify methods of implementing and synthesizing documentary and artistic codes in this work, as well as to determine the main functions of such a synthesis in the conceptual and thematic structure of the story. The study of factual and fictional narratives’ components in the story under consideration has shown that the factual narrative is determined by the author’s concern for authenticity, accuracy and truth, which is revealed through the following elements: using the names and descriptions of real geographical objects, depicting the typical attributes of the era, presenting historical facts and real-life events of our time, portraying real persons as characters. Fictional components include special forms of real facts interpretation: the author’s mode of narration, special narrative strategies, imaginative expression of ideas and themes, using various stylistic means and devices. As a result of such contamination, the author creates a certain model of artistic reality which is based on documentary materials.
Propriedades tecnológicas de bactérias ácido-lácticas em lacticínios: revisão
Authors: Lima Carlos Henrique Gomes de Sousa , Costa Josiane Da Silva , Carbonera Nádia , Helbig Elizabete
Published: March 2023

As bactérias ácido-lácticas (BAL) são um grupo de microrganismos conhecidos como seguros, e que devido aos seus inúmeros metabólitos, contribuem na biopreservação e/ou oferecimento de vantagens nos aspectos organolépticos, tecnológicos, nutricionais ou fisiológicos, e assim, sendo muito aplicável pela indústria láctea. A presente revisão apresenta as características de elevado potencial para seleção de cepas para a indústria de laticínios, como ação antimicrobiana, produção de bacteriocinas, compostos aromáticos, exopolissacarídeos, atividade proteolítica e lipolítica, tolerância ao cloreto de sódio e ação acidificante. Dessa forma, o estudo objetivou relatar aspectos importantes de pesquisas que conduzam à avaliação de BAL com efeitos tecnológicos desejáveis para formulação de produtos com alto valor agregado.
Redução de sódio em derivados lácteos: revisão de alternativas usadas para reduzir o sal em queijos e manteiga
Authors: Machado Hiago Fonseca , Jardim Fernanda Barbosa Borges , Fonseca Carolina Rofrigues da
Published: March 2023

A ingestão, em excesso, de sódio está associada a doenças cardiovasculares. Para melhorar a saúde populacional, no Brasil e no mundo, os cientistas de alimentos buscam alternativas tecnológicas para a redução parcial ou total do cloreto de sódio (NaCl), um dos principais contribuintes para o consumo de sódio. O sal é muito importante para as características microbiológicas, físico-químicas e sensoriais de um alimento, portanto a sua remoção é de grande desafio para a indústria alimentícia. Dentre os alimentos foco de redução de sódio estão alguns derivados lácteos. Este artigo tem como objetivo efetuar um levantamento bibliográfico de pesquisas com foco em redução de sódio em queijos e manteiga e suas soluções para atender as demandas.
Estudo sobre a língua especializada em contextos ocupacionais
Authors: Assumpção Glória de Fátima Pinotti de
Published: March 2023

Este trabalho tem por objetivo apresentar alguns resultados de uma pesquisa em desenvolvimento acerca da estreita relação entre linguagem e trabalho, no âmbito das Ciências do Léxico e os pressupostos teóricos da Terminologia. Selecionamos as deflagrações da Operação Lava-Jato realizada pela Polícia Federal, de 2014 a 2019, da 1ª a 70ª fase operacional de desdobramento. Os resultados respondem aos questionamentos como se constitui a linguagem profissional nessa comunidade de especialistas, como se configuraram as denominações e o perfil léxico-semântico da terminologia encontrada. Nessa primeira etapa da pesquisa, compomos um corpus de estudo com 140 textos, dos quais, 70 textos oficiais, extraídos do sítio do Ministério Público Federal contém informações. Os outros, notícias divulgadas na grande imprensa, foram utilizados como corpus de exclusão. Com o auxílio das ferramentas TermoStat e Adobe, procedemos a captura dos candidatos a termos, dos quais, analisamos 114 sob o ponto de vista da forma, função e procedência, aspectos léxico semânticos, variação e aspectos culturais. Nossas análises indicaram variação das denominações em formas iguais de significados idênticos; formas iguais provenientes de línguas estrangeiras; formas que designam áreas culturais; formas iguais que vulgarizam linguagem de conteúdo específico em contextos ocupacionais; formas que socializam a linguagem especializada, a linguagem coloquial, entre outros.  O presente estudo tem base na Socioterminologia (GAUDIN, 1993), Teoria Comunicativa da Terminologia (TCT) (CABRÉ, 1992/1998) e Variação Terminológica (FAULSTICH, 1995).
Scholars and Literati at the University of Toulouse (1229–1793)
Authors: De la Croix David , Fabre Alice
Published: March 2023

This note summarizes our research into the group of scholars and literati who were at the University of Toulouse between its foundation in 1229 and its dissolution in 1793.
Scholars at the Royal Academy of Sciences in Paris (1666-1793)
Authors: De la Croix David , Zanardello Chiara
Published: March 2023

This note summarizes our research into the scholars of the Royal Academy of Sciences of Paris from its early meetings to its dissolution.
Ползучесть и длительное разрушение узкой прямоугольной мембраны внутри низкой жесткой матрицы
при пропорциональной зависимости величины поперечного давления от времени
Authors: Локощенко Александр Михайлович , Lokoshchenko Alexander Mikhaylovich , Фомин Леонид Викторович , Fomin Leonid Viktorovich , Ахметгалеев Александр Фагимович , Akhmetgaleev Alexander Fagimovich , Махов Денис Дмитриевич , Makhov Denis Dmitrievich
Published: March 2023

Проведено исследование ползучести и длительного разрушения узкой прямоугольной мембраны в стесненных условиях (внутри низкой жесткой матрицы) для случая пропорциональной зависимости величины поперечного давления от времени.
Деформирование мембраны в условиях ползучести рассматривается как последовательность трех стадий.
На первой стадии мембрана деформируется в свободных условиях вплоть до касания поперечной стороны жесткой матрицы.
На второй стадии она деформируется при касании поперечной стенки матрицы вплоть до касания ее продольных стенок.
На третьей стадии она уже деформируется при одновременном касании продольных и поперечной стенок матрицы.
Исследование проводится при двух видах контактных условий: идеальное скольжение мембраны вдоль стенок матрицы и прилипание мембраны к стенкам матрицы.
Анализ постепенного разрушения мембраны проводится при использовании кинетической теории ползучести Ю. Н. Работнова, при этом параметр поврежденности материала в данной задаче имеет скалярный характер.
Полученные уравнения использованы для анализа ползучести и длительного разрушения мембраны, изготовленной из хромомолибденной стали (2.15Cr-Mo steel), деформируемой при переменном поперечном давлении при температуре $600 ^\circ$C вплоть до ее разрушения.
В результате решения системы определяющего и кинетического уравнений получены значения параметра поврежденности, накопленного в течение каждой стадии деформирования, а также величины времени до разрушения мембраны.
Результаты исследования показывают, что в случае разрушения мембраны на первой стадии время до разрушения на первой стадии не зависит от вида контактных условий, а при разрушении мембраны на второй и третьей стадиях деформирования время до разрушения в случае идеального скольжения не меньше, чем в случае прилипания.
Краевые задачи для уравнения соболевского типа дробного порядка c эффектом памяти
Authors: Бештоков Мурат Хамидбиевич , Beshtokov Murat KHamidbievich
Published: March 2023

Изучены краевые задачи для одномерного интегро-дифференциального уравнения соболевского типа с граничными условиями первого и третьего родов с двумя операторами дробного дифференцирования $\alpha$ и $\beta$ разных порядков.
Построены разностные схемы порядка аппроксимации $O(h^2+\tau^2)$ при $\alpha=\beta$ и $O(h^2+\tau^{2-\max\{\alpha,\beta\}})$ при $\alpha\neq\beta$.
С помощью метода энергетических неравенств получены априорные оценки в дифференциальной и разностной трактовках, откуда следуют существование, единственность, устойчивость, а также сходимость решения разностной задачи к решению исходной дифференциальной задачи со скоростью, равной порядку аппроксимации разностной схемы. Проведены численные эксперименты, иллюстрирующие полученные в работе результаты.
When You Do Not Fit In: Ugliness as a Theological Problem
Authors: Cielontko Dávid , Zámečník Jan
Published: March 2023

The article draws attention to the ethical and pastoral dangers associated with the theological subordination of ugliness to other purposes, such as universal harmony and order, the search for the immutable, or divination. It also traces the tendency to conflate moral and aesthetic ugliness, which has led to the marginalisation or even persecution of others on the basis of their outward appearance. As a counterpoint to these tendencies, the article emphasises the idea of the ugly suffering servant Christ, which contains pastoral and countercultural potential.
How Beauty is Dying
Authors: Hanuš Jiří
Published: March 2023

In his essay, the author reflects on the death of ‘beauty’ within the context of the present state of nature (the phenomenon of the forest and its problems), modern art (the transformations within visual art) and language (the demise of dialects, the destruction of language by contemporary ideologies). The fact that ‘beauty’ is not merely a subjective category and is not purely a matter of individual taste means that we can rationally discuss its renewal (nature), the talent, craftsmanship and diligence involved (art), and the relationship between language ideas and thoughts (how ‘nicely’ we speak).
And Beauty Will Make You Free: On the Transformative Power of Beauty
Authors: Bargár Pavol
Published: March 2023

In allusion to the famous Johannine dictum, this paper seeks to explore the relationship between beauty and liberation. Liberation is here understood in terms of a movement toward transforming all reality in accordance with the principles of the coming reign of God, ‘so that God may be all in all’ (1 Cor 15:28). Complementarily, beauty is not interpreted merely as a matter of taste and preference but as something that permeates all dimensions of being human. The paper, therefore, argues that beauty not only gives expression to the human yearning for transformation but that both beauty and liberation represent the constitutive elements of Christian praxis. Thus, beauty provides a framework through which the current reality can not only be seen but also discerned, experienced, and performed in a new way, thus effectively opening up possibilities for transformation as God’s project of inaugurating a new heaven and a new earth. Therefore, it will be proposed that beauty represents a key theme for theological reflection (locus theologicus), having aesthetic, ethical, and ontological implications for Christian theology. This point will not only be discussed in conversation with various theological voices but also illustrated through engagement with cinema, namely, Jane Campion’s The Power of the Dog.
Less Known Iconography of the Immaculate Conception of the Virgin Mary in the Prague Loreto in Connection with the Teaching of St Lawrence of Brindisi
Authors: Vymazalová Marie
Published: March 2023

The text describes and contextualises collections of sermons by Lawrence of Brindisi about the Virgin Mary called Mariale, mainly the sermons about the teachings of the Immaculate Conception of the Virgin Mary. Lawrence of Brindisi, a capuchin monk and a European diplomat, was an important person in European church history of the 16th and the 17th centuries, but his texts are not yet fully appreciated. The text compares the theological question with the works of art from Prague Loreta. The comparison of the layout of this Marian pilgrimage place and thoughts of Franciscan spirituality contained in Lawrence’s sermons demonstrates the mutual interconnection between the specific period of theological thinking and a particular example of artistic expression.
Till and Keep and God’s Indwelling
Authors: Ferreira Felipe Dittrich
Published: March 2023

This article proposes to restore the understanding of Genesis 1-2 not as an innocent prelude for the Fall, but as the blueprint for the unfolding of God’s plan for the created world. In this context, the idea that humankind was given the image of God is articulated with the instructions given by God in paradise: naming the animals (Gn 2:19), tilling and keeping the soil (Gn 2:15), multiplying, and filling and mastering the Earth (Gn 1:28). Such tasks would have the function of guiding the human development towards the likeness of God, while contributing at the same time to Earth’s development, according to the model furnished by the garden of Eden, arguably meant to be extended and multiplied. The final objective of such efforts would be to prepare the Earth for God’s indwelling. The Parable of the Ten Virgins (Matthew 25:1–13), along with the Parable of the Faithful Servant (Matthew 24:42–51; Mark 13:34–37; Luke 12:35–48) could be said to warrant such interpretation.
Ivana Noble, Zdenko Širka (eds.), Kdo je člověk – Teologická antropogie ekumenicky
Authors: Brůhová Daniela
Published: March 2023

Book review on Ivana Noble, Zdenko Širka (eds.), Kdo je člověk –Teologická antropogie ekumenicky [Who Is the Human Being in Relation to God – Theological Anthropology Ecumenically], Praha: Karolinum, 2021, 344 pages, ISBN: 978-80-246-4779-1.
Confort térmico en edificios educativos naturalmente ventilados: un estudio en bioclima templado-seco
Authors: Rincón-Martínez Julio Cesar
Published: March 2023

El bienestar, la eficiencia y el confort de las personas pueden verse afectados por las condiciones adversas del ambiente térmico. En México, los estudios que abordan dicho fenómeno se han desarrollado principalmente en sitios con bioclimas cálidos (seco y húmedo), y poca investigación hay sobre bioclimas templados o semifríos. Este trabajo presenta los resultados de un estudio sobre confort térmico desarrollado con el enfoque adaptativo, en edificios naturalmente ventilados, durante la transición térmica del periodo frío al periodo cálido en Ensenada, Baja California (bioclima templado-seco). El estudio es de tipo correlacional y fue analizado con 987 evaluaciones y el registro simultáneo de la temperatura, la humedad relativa y la velocidad de viento, durante el periodo del 24 de abril al 22 de mayo de 2017. Los cuestionarios aplicados se diseñaron con la ISO 10551 y la ANSI/ASHRAE 55; asimismo, los instrumentos de medición responden a la ISO 7726. Los datos recabados fueron procesados estadísticamente con el método de medias por intervalos de sensación térmica. La temperatura neutra resultó en 20,2 °C, con un rango de confort de 17,7 °C-22,7 °C; los sujetos reflejaron mayor adaptación a temperaturas por encima de la temperatura neutra, a partir del emprendimiento de acciones voluntarias o involuntarias cuyo objetivo se enfocaba en reanudar el confort térmico de forma inmediata.
Validación de una prueba estandarizada de desempeño para la selección de estudiantes de Arquitectura con el Modelo de Rasch de Facetas Múltiples
Authors: Hernández-Ureña Olman , Montero-Rojas Eiliana
Published: March 2023

En una evaluación del desempeño se crea un producto o se desarrolla un proceso, que es evaluado por varios calificadores. El Modelo de Rasch de Facetas Múltiples (MRFM), extensión del modelo de Rasch, cuantifica diversos atributos asociados a la calidad de la medición en tales evaluaciones, incluyendo la concordancia entre calificadores, cualidad esencial para la validez. Los datos provienen de una prueba de desempeño aplicada con propósitos de selección en la Escuela de Arquitectura de la Universidad de Costa Rica (UCR). Se analizaron las aplicaciones de la prueba del 2015 al 2018, cada una tenía entre 600 y 800 examinados. Cada producto fue evaluado por tres calificadores, y los equipos de calificadores tenían entre 12 y 15 miembros. Los tres primeros años mostraron alto grado de variabilidad entre las severidades de los calificadores, dispersándose más de 2 logits, en la escala de Rasch. En 2018 se introdujeron modificaciones para mejorar la concordancia entre los calificadores, y los análisis correspondientes mostraron una disminución relevante en la dispersión de las severidades, con un rango de 1.09 logits. El estudio ilustra los beneficios de este modelo para analizar y mejorar la calidad técnica de una evaluación del desempeño de alto impacto.
Hábitat popular. Modelo sistémico para abordar una propuesta de solución habitacional y su inserción urbana
Authors: San Juan Gustavo Alberto , Viegas Graciela Melissa , Reynoso Laura Elena , Esparza Jesica Belén
Published: March 2023

El hábitat y la vivienda orientados a sectores sociales de bajos ingresos que conforman asentamientos informales periféricos son un tema relevante para reflexionar en toda América Latina. Este trabajo tiene por objetivo aportar al debate en la implementación de políticas públicas y, fundamentalmente, exponer soluciones que se vienen desarrollando entre diferentes actores del Estado, a partir de una metodología abierta, sistémica y dinámica, surgidas en el ámbito de la investigación-acción, para mejorar la calidad de vida en el hábitat popular. La identificación y la cuantificación de sectores sociales vulnerables, y aquellos de mayor riesgo localizados en la región del Gran La Plata (GLP), Argentina, así como la propuesta de soluciones habitacionales y sus componentes asociados, se enmarca en la producción de tecnología para la inclusión social a partir de una gestión participativa cogestionada. Los resultados muestran las posibilidades de una metodología que permite pensar soluciones habitacionales con aceptación social, para su implementación en distintos sectores urbanos.
Anonymous Edge Representation for Inductive Anomaly Detection in Dynamic Bipartite Graph
Authors: Fang Lanting , Feng Kaiyu , Gui Jie , Feng Shanshan , Hu Aiqun
Published: March 2023

The activities in many real-world applications, such as e-commerce and online education, are usually modeled as a dynamic bipartite graph that evolves over time. It is a critical task to detect anomalies inductively in a dynamic bipartite graph. Previous approaches either focus on detecting pre-defined types of anomalies or cannot handle nodes that are unseen during the training stage. To address this challenge, we propose an effective method to learn anonymous edge representation (AER) that captures the characteristics of an edge without using identity information. We further propose a model named AER-AD to utilize AER to detect anomalies in dynamic bipartite graphs in an inductive setting. Extensive experiments on both real-life and synthetic datasets are conducted to illustrate that AER-AD outperforms state-of-the-art baselines. In terms of AUC and F1, AER-AD is able to achieve 8.38% and 14.98% higher results than the best inductive representation baselines, and 6.99% and 19.59% than the best anomaly detection baselines.
Scalable Time-Range
k
-Core Query on Temporal Graphs
Authors: Yang Junyong , Zhong Ming , Zhu Yuanyuan , Qian Tieyun , Liu Mengchi , Yu Jeffrey Xu
Published: March 2023

Querying cohesive subgraphs on temporal graphs with various time constraints has attracted intensive research interests recently. In this paper, we study a novel Temporal
k
-Core Query (TCQ) problem: given a time interval, find all distinct
k
-cores that exist within any subintervals from a temporal graph, which generalizes the previous historical
k
-core query. This problem is challenging because the number of subintervals increases quadratically to the span of time interval. For that, we propose a novel Temporal Core Decomposition (TCD) algorithm that decrementally induces temporal
k
-cores from the previously induced ones and thus reduces "intra-core" redundant computation significantly. Then, we introduce an intuitive concept named Tightest Time Interval (TTI) for temporal
k
-core, and design an optimization technique with theoretical guarantee that leverages TTI as a key to predict which subintervals will induce duplicated
k
-cores and prunes the subintervals completely in advance, thereby eliminating "inter-core" redundant computation. The complexity of optimized TCD (OTCD) algorithm no longer depends on the span of query time interval but only the scale of final results, which means OTCD algorithm is scalable. Moreover, we propose a compact in-memory data structure named Temporal Edge List (TEL) to implement OTCD algorithm efficiently in physical level with bounded memory requirement. TEL organizes temporal edges in a "timeline" and can be updated instantly when new edges arrive in dynamical temporal graphs. We compare OTCD algorithm with the incremental historical
k
-core query on several real-world temporal graphs, and observe that OTCD algorithm outperforms it by three orders of magnitude, even though OTCD algorithm needs none precomputed index.
Stimulation of spinal cord according to recorded theta hippocampal rhythm during rat move on treadmill
Authors: Rouhi Shahin , Rahmani Saeid , Shanesazzadeh Faezeh , Ahmadvand Tala , Namazi Mahrokh , Fardmanesh Mehdi , Kiani Sahar
Published: March 2023

Objectives

Several studies have revealed that after spinal cord injury (SCI), in acute and sub-acute phase the spinal cord neurons below the injury are alive and could stimulate by use of electrical pulses. Spinal cord electrical stimulation could generate movement for paralyzed limbs and is a rehabilitation strategy for paralyzed patients. An innovative idea for controlling spinal cord electrical stimulation onset time is presented in current study.

Methods

In our method, the time of applying electrical pulse on the spinal cord is according to rat behavioral movement and two movements behaviors are recognized only based on rat EEG theta rhythm on the treadmill line. Briefly, 5 rats were placed on the treadmill and the animals experienced zero or 12 m/min speeds.

Results

These speeds were recognized based on EEG signals and off-line periodogram analysis. Finally, the electrical stimulation pulses had been applied to the spinal cord if the results of the EEG analysis had detected running behavior.

Conclusions

These findings may guide future research in utilizing theta rhythms for the recognition of animal motor behavior and designing electrical stimulation systems based on it.
Lower accuracy of testosterone, cortisol, and free T4 measurements using automated immunoassays in people undergoing hemodialysis
Authors: Jansen Heleen I. , van Herwaarden Antonius E. , Huijgen Henk J. , Vervloet Marc G. , Hillebrand Jacquelien J. , Boelen Anita , Heijboer Annemieke C.
Published: March 2023

Objectives

Hormone measurements using automated immunoassays (IAs) can be affected by the sample matrix. Liquid chromatography tandem-mass spectrometry (LC-MS/MS) is less affected by these matrix effects. In clinical laboratories, testosterone, cortisol and, free thyroxine (FT4) are often measured using IAs. Renal failure alters serum composition in blood samples from people undergoing hemodialysis (HDp) and have, therefore, a complex serum constitution compared to healthy controls (HC). The goal of this study was to investigate the accuracy of testosterone, cortisol, and FT4 measurements in samples of HDp and to get more insight in the interfering factors.

Methods

Thirty serum samples from HDp and HC were collected to measure testosterone, cortisol, and FT4 using a well standardized isotope dilution (ID)-LC-MS/MS method and 5 commercially available automated IAs (Alinity, Atellica, Cobas, Lumipulse, UniCel DXI). Method comparisons between LC-MS/MS and IAs were performed using both HDp and HC samples.

Results

Average bias from the LC-MS/MS was for testosterone, cortisol, and FT4 immunoassays respectively up to 92, 7–47 and 16–27% more in HDp than in HC samples and was IA dependent. FT4 IA results were falsely decreased in HDp samples, whereas cortisol and testosterone concentrations in females were predominantly falsely increased. Correlation coefficients between LC-MS/MS and IA results were lower in HDp compared to HC samples.

Conclusions

Several IAs for testosterone (in women), cortisol, and FT4 are less reliable in the altered serum matrix of samples of HDp than in HC. Medical and laboratory specialists should be aware of these pitfalls in this specific population.
An unexpected case of neonatal compartment syndrome associated with congenital anomalies of kidney and urinary tract
Authors: Seske Laura M. , Mastroianni Melissa , Aziz Keith T. , Lewallen Laura W.
Published: March 2023

Objectives

Neonatal compartment syndrome (NCS) occurs when increased pressure within the fasciocutaneous compartment decreases capillary perfusion, causing irreversible tissue damage from ischemia. NCS is a rare condition that requires prompt diagnosis and treatment. Diagnosing NCS is highly dependent on the examination, which can be difficult in newborns. Prompt recognition provides the best chance for good outcomes.

Case presentation

We present a case of NCS diagnosed and treated based on physical examination findings. Fetal ultrasonography showed bladder distension, bilateral hydroceles, urethra dilation, and abdominal urinary ascites concerning for lower urinary tract obstruction and possible bladder rupture. At 1 h after birth, examination of the infant’s left upper extremity showed no spontaneous movement, the hand and forearm appeared dusky, and the hand had a large blister with desquamation. No pulse distal to the antecubital fossa was detected via Doppler ultrasonography. The infant was diagnosed with NCS and underwent urgent fasciotomy. The clinical appearance and perfusion of the left upper extremity gradually improved. At four months of age, the wounds were healed and the patient had full passive range of motion of the left upper extremity. Recovery of active motion is ongoing.

Conclusions

The presence of blistering and desquamation should provoke suspicion for NCS. Once NCS is diagnosed, prompt intervention is necessary to reduce the risk of poor functional outcomes. This case highlights the need for increased awareness of the risk developing compartment syndrome in utero as part of the rare sequalae in infants with congenital anomalies of kidney and urinary tract.
Confinement of ozone hole mainly in the Antarctic stratosphere to protect the living kingdom on the earth: chemistry behind this Nature’s unique gift
Authors: Das Udita , Das Ankita , Das Asim K.
Published: March 2023

Man-made activities can release the ozone depleting substances (ODSs) like chlorofluorocarbons (CFCs) and other halocarbons stable in atmosphere and ultimately, they migrate to the stratosphere where they can destroy the ozone layer through the XOx catalytic cycle (X = Cl, Br). The active forms in this catalytic cycle are X and XO that can be arrested in the inactive forms like XONO2 (halogen nitrate, an additive compound of two odd electron molecules XO and NO2) and HX (produced in the reaction of X with CH4) in the stratosphere to prevent the ozone depletion cycle. The catalytically active forms from these inactive species can be regenerated in the reactions on heterogeneous solid surface like polar stratospheric cloud (specially Type II PSC formed at about −85 °C). Formation of such PSC in the stratosphere is only possible in the supercooled stable Antarctic vortex produced in the prolonged winter. In fact, formation of such PSC in the stratosphere is not possible in the other regions of the earth and not even in the Arctic pole where no stable Arctic vortex is generally formed in the winter. Thus nature confines the ozone depletion reactions mainly in the stratosphere of Antarctica pole which is practically inhabited.
Analysis of common biomarkers in capillary blood in routine clinical laboratory. Preanalytical and analytical comparison with venous blood
Authors: Maroto-García Julia , Deza Sara , Fuentes-Bullejos Patricia , Fernández-Tomás Patricia , Martínez-Espartosa Débora , Marcos-Jubilar María , Varo Nerea , González Álvaro
Published: March 2023

Objectives

Remote self-collected capillary blood samples have been proposed as alternative to venous blood samples as an aid in telemedicine. The aim of this work is to compare the preanalytical and analytical performance of these two types of samples and to study the stability of common measurands in capillary blood.

Methods

Capillary and venous blood samples were collected in parallel from 296 patients in serum tubes to analyze 22 common biochemistry magnitudes after centrifugation and in EDTA tubes to analyze 15 hematologic magnitudes. Quality of the preanalytical process was assessed applying the model of quality indicator. 24 h stability at room temperature was studied by obtaining paired capillary samples. A questionnaire of assessment was conducted.

Results

Mean hemolysis index was higher in capillary samples compared to venous blood samples (p<0.001). Regression analysis and difference analysis showed no bias for all studied biochemistry parameters and hematologic parameters, except mean corpuscular volume (MCV), between capillary and venous blood samples. Regarding sample stability, percentage deviation was higher than the corresponding minimum analytical performance specification for ferritin, vitamin D, hematocrit, MCV, mean corpuscular hemoglobin concentration, platelets distribution wide, mean platelet volume and basophils. Finger pricking was perceived as less painful (p<0.05) than venipuncture in participants who undergo more than one blood test per year.

Conclusions

Capillary blood can be used as an alternative to venous blood for the studied parameters in automated common clinical analyzers. Cautious should be taken if samples are not analyzed within 24 h from the collection.
Soft sensor method of multimode BOF steelmaking endpoint carbon content and temperature based on vMF-WSAE dynamic deep learning
Authors: Yang Lu , Liu Hui , Chen Fugang
Published: March 2023

The difficulty of endpoint determination in basic oxygen furnace (BOF) steelmaking lies in achieving accurate real-time measurements of carbon content and temperature. For the characteristics of serious nonlinearity between process data, deep learning can perform excellent nonlinear feature representation for complex structural data. However, there is a process drift phenomenon in BOF steelmaking, and the existing deep learning-based soft sensor models cannot adapt to changes in the characteristics of samples, which may lead to their performance degradation. To deal with this problem, considering the characteristics of multimode distribution of process data, an adaptive updating deep learning model based on von-Mises Fisher (vMF) mixture model and weighted stacked autoencoder is proposed. First, the stacked autoencoder (SAE) and vMF mixture model are constructed for complex structural data, which can initially establish nonlinear mapping relationships and division of different distributions. Second, for each query sample, the basic SAE network will perform online adaptive fine-tuning according to its data with the same distribution to achieve dynamic updating. Moreover, each sample is assigned a weight according to its similarity with the query sample. Through the designed weighted loss function, the updated deep network will better match the working conditions of the query sample. Experimental studies with numerical examples and actual BOF steelmaking process data are provided to demonstrate the effectiveness of the proposed method.
Generalized Onsager fluxes based on inexact differential 1-form
Authors: Yang Qiang , Leng Kuangdai , Zhang Man , Liu Yaoru
Published: March 2023

Onsager fluxes proposed by D.G.B. Edelen assume that the same symmetry, nonlinear Onsager reciprocal relations, holds near and far from equilibrium. This assumption leads to exact differential 1-form J ⋅ dX everywhere, where J and X are thermodynamic fluxes and forces, respectively. However, thermodynamic fluxes far from equilibrium are characterized by symmetry breaking, which lead to the inexact differential 1-form. It is shown in this paper that the inexact differential 1-form J ⋅ dX should be represented by multiple independent scalar-valued functions. Generalized Onsager fluxes are obtained based on such representation. Generalized Onsager fluxes do not satisfy the nonlinear Onsager reciprocal relations and contain multiple independent scalar-valued functions, so they are suitable to thermodynamic fluxes far from equilibrium. Generalized Onsager fluxes embody Onsager fluxes as a special case. Therefore, generalized Onsager fluxes provide a unified framework for thermodynamic fluxes near and far from equilibrium.
Concentration levels and risk assessment of organochlorine and organophosphate pesticide residue in selected cereals and legumes sold in Anambra State, south-eastern Nigeria
Authors: Omokpariola Patrick Leonard , Okoye Patrice A. C. , Okechukwu Victor U. , Omokpariola Daniel Omeodisemi
Published: March 2023

The levels of organochlorine and organophosphate pesticide residues in selected cereal crops (beans, cowpea, millet, maize, sorghum, and rice) purchased from major markets in Anambra, south-eastern Nigeria, were assessed and compared with established MRLs. The QuEChERS (quick, easy, cheap, effective, rugged, and safe) method was used for extraction and clean-up of pesticide residues. Thereafter detection and quantification were done using GC/MS. The result reveals that the analysed grain samples contained some organochlorine pesticides and organophosphates. The organochlorine was most dominant followed by the organophosphates. Organochlorine pesticide residues varied from 0.048 to 0.298 mg/kg in beans, BDL to 0.398 mg/kg in cowpea, 0.018–0.337 mg/kg in maize, 0.023–0.375 mg/kg in millet, 0.058–0.415 mg/kg in sorghum and 0.045–0.442 mg/kg in rice while organophosphate pesticide residue varied from BDL to 0.315 mg/kg in beans, BDL to 0.113 mg/kg in cowpea, BDL to 0.228 mg/kg in maize, BDL to 0.253 mg/kg in millet, BDL to 0.218 mg/kg in sorghum and BDL to 2.1 35 mg/kg in rice. Highest concentration of endosulphan II (0.442 mg/kg) was detected in rice, followed by aldrin (0.415 mg kg−1) in sorghum and endosulphan II (0.40 mg/kg) in sorghum. The pesticide toxicity index (PTI) was above one (1), whereas health index (HI) was less than one (1) and cancer risk were within USEPA reference guideline for crops indicating children will have greater health effect than adults. Hence, strict monitoring and control of pesticide residues in agricultural products is advocated.
GRM2 Regulates Functional Integration of Adult-Born DGCs by Paradoxically Modulating MEK/ERK1/2 Pathway
Authors: Ma Jiao , Hu Zhechun , Yue Huimin , Luo Yujian , Wang Chao , Wu Xuan , Gu Yan , Wang Lang
Published: March 2023

Metabotropic glutamate receptor 2 (GRM2) is highly expressed in hippocampal dentate granule cells (DGCs), regulating synaptic transmission and hippocampal functions. Newborn DGCs are continuously generated throughout life and express GRM2 when they are mature. However, it remained unclear whether and how GRM2 regulates the development and integration of these newborn neurons. We discovered that the expression of GRM2 in adult-born DGCs increased with neuronal development in mice of both sexes. Lack of GRM2 caused developmental defects of DGCs and impaired hippocampus-dependent cognitive functions. Intriguingly, our data showed that knockdown ofGrm2resulted in decreased b/c-Raf kinases and paradoxically led to an excessive activation of MEK/ERK1/2 pathway. Inhibition of MEK ameliorated the developmental defects caused byGrm2knockdown. Together, our results indicate that GRM2 is necessary for the development and functional integration of newborn DGCs in the adult hippocampus through regulating the phosphorylation and activation state of MEK/ERK1/2 pathway.

SIGNIFICANCE STATEMENTMetabotropic glutamate receptor 2 (GRM2) is highly expressed in mature dentate granule cells (DGCs) in the hippocampus. It remains unclear whether GRM2 is required for the development and integration of adult-born DGCs. We providedin vivoandin vitroevidence to show that GRM2 regulates the development of adult-born DGCs and their integration into existing hippocampal circuits. Lack of GRM2 in a cohort of newborn DGCs impaired object-to-location memory in mice. Moreover, we revealed that GRM2 knockdown paradoxically upregulated MEK/ERK1/2 pathway by suppressing b/c-Raf in developing neurons, which is likely a common mechanism underlying the regulation of the development of neurons expressing GRM2. Thus, Raf/MEK/ERK1/2 pathway could be a potential target for brain diseases related to GRM2 abnormality.
MitoStores: a place for precursors to ride out the storm
Authors: Balzarini Megan , Yuan Zixuan , Weidberg Hilla
Published: March 2023

The fate of unimported mitochondrial precursors has been increasingly studied in recent years, mostly focusing on protein degradation. In this issue of the EMBO journal, Krämer et al discovered MitoStores, a new protective mechanism that temporarily stores mitochondrial proteins in cytosolic deposits.
In viral games, refs go to the replay
Authors: Rochman Nash D
Published: March 2023

After more than 2 years of intensive investigation, the direct ancestors of the novel severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) remain unidentified. Molecular epidemiology strongly supports a timeline marked by multiple, independent zoonoses in late 2019 (Pekar et al, 2022) solidifying the consensus hypothesis that close relatives of SARS‐CoV‐2 with high zoonotic potential were naturally circulating prior to the start of the pandemic (Andersen et al, 2020). Understanding where and when these ancestors acquired the genomic features that resulted in a virus with epidemic potential could enable the identification and mitigation of future pandemic viruses, even before the first human infection.
The Intricate Justice of Poverty: A Case of The Land of Gold in Papua Indonesia
Authors: Hidayatulloh Hidayatulloh , Erdős Éva , Szabó Miklós
Published: March 2023

Natural wealth does not guarantee the welfare of its inhabitants. This case occurred in Papua, the easternmost region of Indonesia, which won the title of the poorest province from 2017 to 2021. Freeport McMoRan, an American mining corporation operating since 1967, failed to present a positive impact on the welfare of the Papuan people despite having dredged a lot of money from Grasberg, one of the largest reserves of gold and copper in the world. This paper reviews the portrait of abject poverty in Papua and analyzes its problems with the rights and justice approach. In conclusion, this paper finds that poverty for the Papuan people is very complicated because it is related to the historical roots of colonialism, capitalism, and armed conflicts. The special autonomy granted by the Indonesian government for twenty years has not been able to provide for people's welfare due to violent conflicts, human rights violations, natural destruction, and corruption. The Indonesian government is obliged to realize justice in the economic, political, and cultural dimensions for the welfare of the Papuan people.
COL12A1 as a prognostic biomarker links immunotherapy response in breast cancer
Authors: Yan Yuanliang , Liang Qiuju , Liu Yuanhong , Zhou Shangjun , Xu Zhijie
Published: March 2023

Immunotherapy has shown promising efficacy for breast cancer (BC) patients. Yet the predictive biomarkers for immunotherapy response remain lacking. Based on two GEO datasets, 53 differentially expressed genes associated with durvalumab treatment response were identified. Using least absolute shrinkage and selection operator (LASSO) and univariate Cox regression, four genes (COL12A1, TNN, SCUBE2, and FDCSP) revealed prognostic value in the TCGA BC cohort. COL12A1 outperformed the others, without overlap in its survival curve. Survival analysis by Kaplan–Meier plotter demonstrated that COL12A1 was negatively associated with BC patients’ prognosis. A COL12A1-based nomogram was further developed to predict the overall survival in BC patients. The calibration plot revealed an optimal agreement between nomogram prediction and actual observation. Moreover, COL12A1 expression was significantly up-regulated in BC tissues and COL12A1 knockdown impaired the proliferation of MDA-MB-231 and BT549 cells. Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, and Gene Set Enrichment analysis pathway indicated that the function of COL12A1 was related to immunity-related pathways. Immunological analyses illustrated that COL12A1 was correlated with M2 macrophage infiltration and M2 macrophage markers (transforming growth factor beta 1 (TGFB1), interleukin-10, colony stimulating factor 1 receptor (CSF1R) and CD163) in BC. Immunohistochemistry staining further revealed a highly positive relationship of COL12A1 with TGF-β1. The co-incubated models of BC cells and M2 macrophges showed COL12A1 knockdown suppressed M2 macrophage infiltration. Additionally, silencing COL12A1 suppressed TGF-B1 protein expression, and treating with TGFB1 could reverse the inhibitory effects on M2 macrophage infiltration by COL12A1 knockdown. Using immunotherapy datasets, we also found elevated expression of COL12A1 predicted poor response to anti-PD-1/PD-L1 therapy. These results reinforce the current understanding of COL12A1’s roles in tumorigenesis and immunotherapy response in BC.
Aprendentes espanhóis de Português língua estrangeira: atribuição de género gramatical em palavras sufixadas
Authors: Santos Ferreira Tânia , Rio-Torto Graça
Published: March 2023

Este estudo visa analisar a atribuição de género gramatical em derivados sufixados do português por aprendentes tardios, nativos de espanhol, a frequentar turmas de diferentes níveis de aprendizagem, de A1 a C2. No inquérito aplicado, foram selecionados nomes de evento, de estado e/ou de propriedade, portadores de sufixos inscritos em classes temáticas marcadas por grande opacidade, como os nomes atemáticos, sufixados em -agem, os de Tema ø ([ɐ̃w̃]), sufixados em -ão, ‑ção e -s[z]ão e os de Tema ‑e (invariável), sufixados em -ice e -idade. Partindo da análise dos dados empíricos, registou‑se, em termos globais, uma diminuição considerável de desvios à medida que os aprendentes progridem na aprendizagem do português, já que no segmento dos informantes dos níveis C1-C2, os valores de desvios apurados foram residuais. Verificou-se ainda, e sobretudo nos níveis iniciais e intermédios, uma elevada incidência de desvios nos nomes femininos sufixados em -agem que estará correlacionada com o facto de o cognato espanhol -aje originar nomes de género masculino. Assim, esta assimetria traduz-se, especialmente em fases iniciais da aprendizagem, por efeitos de transferência linguística no desempenho destes aprendentes. Além disso, os elevados índices de desvios apurados entre os nomes sufixados em ‑ice e também entre os itens sufixados em -ão são reveladores de que o grau de representatividade e de opacidade do sufixo no input condicionam a atribuição de valores de género aos nomes.
La lectura literaria ante el desafío digital
Authors: Gullón Germán
Published: March 2023

La teoría literaria se ve obligada a desplegar sus alas de nuevo. La lectura digital pide un lugar en el podio cultural, un estatus propio, distinto al de la obra impresa en papel. Tenemos que expandir el concepto de Humanidades al de Humanidades digitales, pero por desgracia la mayoría de las propuestas de investigación que se hacen tienen más que ver con los programas y ordenadores que con las humanidades y poco con la interpretación de lo creado e ideado por el hombre. Propongo en este trabajo que entendamos al lector como confabulador, uno que sabe mezclar, complementar, las diferentes extensiones, visuales, sonoras, que el texto sugiere, y así podemos llegar a comprender la complejidad y riqueza que permite la lectura digital. Abordo varios modos en que el lector es confabulador, el que mezcla imágenes, colores, y sonidos, mediante los vínculos del hipertexto. Además, revisamos tres maneras en que la experiencia lectora digital se guarda mejor en la memoria.
Mundos imposibles: autoficción
Authors: Martín Jiménez Alfonso
Published: March 2023

En este artículo se tratan de explicar la autoficción (que se produce en las obras literarias en las que el autor real experimenta sucesos ficticios, ya sean verosímiles o inverosímiles) como una ruptura de la lógica ficcional (metalepsis), con la consiguiente creación de mundos imposibles. Además, se analizan los distintos tipos de autoficción, y se tratan de explicar a través de un modelo textual de los géneros literarios.
El entramado simbólico en el drama Pelléas et Mélisande de Maurice Maeterlinck. Una aplicación de la Poética de lo imaginario
Authors: Pujante David
Published: March 2023

Este trabajo procura desentrañar el significado simbólico de la obra capital de Maurice Maeterlinck Pelléas et Mélisande, atendiendo a las aportaciones que debemos a Gaston Bachelard, en cuanto a las asociaciones de imágenes y símbolos en la literatura; a Mircea Eliade en lo que respecta a la permanencia histórica de símbolos en la historia de la de la psique humana; y muy especialmente a los planteamientos de la poética del imaginario, con especial atención a la obra de Gilbert Durand Las estructuras antropológicas de lo imaginario.
Nanocellulose and polysiloxane coatings for strength enhancement and oil-proof and hydrophobicity improvement of recycled pulp sheets
Authors: Yi Kai , Fu Shiyu , Yi Zede , Yang Xuedi , Lan Xingyu
Published: March 2023

Recycled fibers are essential raw materials used by the paper industry. However, the strength of the formed paper may fall off excessively after several cycles of reuse of the fibers. Herein, the authors measured the changes in physical properties and fiber size after multiple recycling of fibers and prepared a handsheet from fiber recycled different times. Then the handsheets made with fibers that had been recycled 5 times were double-coated with nanocellulose derivatives to obtain oleophobic and hydrophobic paper. The first layer applied to the paper was cellulose nanofibril (CNF), and the second coating contained polydimethylsiloxane (PDMS) and CNF (CNFmp). The physical properties and barrier performance of coated paper were greatly improved compared to recycling paper. The water contact angle of the coated paper was as high as 139.8° and the Cobb60 value was 35.18±2.15 g/m2. The oil contact angle was 97.1°, and the oil kit number was 12/12.