bluuebunny/crossref_metadata_2025 huggingface dataset:
An Evaluation of Real-world Smart Sock–Based Temperature Monitoring Data as a Physiological Indicator of Early Diabetic Foot Injury: Case-Control Study
Authors: Reyzelman Alexander M , Shih Chia-Ding , Tovmassian Gregory , Nathan Mohan , Ma Ran , Scholten Henk Jan , Malhotra Kara , Armstrong David G
Published: January 2022

Background

Lower extremity complications of diabetes represent major health care complications both in terms of cost and impact to quality of life for patients with diabetic peripheral neuropathy. Temperature monitoring has been shown in previous studies to provide a useful signal of inflammation that may indicate the early presence of a foot injury.

Objective

In this study, we evaluated the temperature data for patients that presented with a diabetic foot injury while using a sock-based remote temperature monitoring device.

Methods

The study abstracted data from patients who were enrolled in a remote temperature monitoring program (2020-2021) using a smart sock (Siren Care). In the study cohort, a total of 5 participants with a diabetes-related lower extremity injury during the study period were identified. In the second comparison cohort, a total of 26 patients met the criteria for monitoring by the same methods but did not present with a diabetes-related podiatric lower extremity injury during the same period. The 15-day temperature differential between 6 defined locations on each foot was the primary outcome measure among subjects who presented with a diagnosed foot injury. Paired t tests were used to compare the differences between the two groups.

Results

A significant difference in temperature differential (temperature measured in °F) was observed in the group that presented with a podiatric injury over the course of evaluation versus the comparator group that did not present with a podiatric injury. The average difference from all 6 measured points was 1.4 °F between the injury group (mean 3.6, SD 3.0) and the comparator group (mean 2.2, SD 2.5, t=–71.4, df=39; P<.001).

Conclusions

The results of this study suggest temperature monitoring in a sock form factor could be used to predict a developing foot injury. The continuous temperature monitoring system employed has implications for further algorithm development to enable early detection. The study was limited by a nonrandomized, observational design with limited injuries present in the study period. We look forward to further studies that will refine the predictive potential and confirm or refute the current promising data.
User Perceptions and Use of an Enhanced Electronic Health Record in Rwanda With and Without Clinical Alerts: Cross-sectional Survey
Authors: Fraser Hamish S F , Mugisha Michael , Remera Eric , Ngenzi Joseph Lune , Richards Janise , Santas Xenophon , Naidoo Wayne , Seebregts Christopher , Condo Jeanine , Umubyeyi Aline
Published: January 2022

Background

Electronic health records (EHRs) have been implemented in many low-resource settings but lack strong evidence for usability, use, user confidence, scalability, and sustainability.

Objective

This study aimed to evaluate staff use and perceptions of an EHR widely used for HIV care in >300 health facilities in Rwanda, providing evidence on factors influencing current performance, scalability, and sustainability.

Methods

A randomized, cross-sectional, structured interview survey of health center staff was designed to assess functionality, use, and attitudes toward the EHR and clinical alerts. This study used the associated randomized clinical trial study sample (56/112, 50% sites received an enhanced EHR), pulling 27 (50%) sites from each group. Free-text comments were analyzed thematically using inductive coding.

Results

Of the 100 participants, 90 (90% response rate) were interviewed at 54 health centers: 44 (49%) participants were clinical and 46 (51%) were technical. The EHR top uses were to access client data easily or quickly (62/90, 69%), update patient records (56/89, 63%), create new patient records (49/88, 56%), generate various reports (38/85, 45%), and review previous records (43/89, 48%). In addition, >90% (81/90) of respondents agreed that the EHR made it easier to make informed decisions, was worth using, and has improved patient information quality. Regarding availability, (66/88) 75% said they could always or almost always count on the EHR being available, whereas (6/88) 7% said never/almost never. In intervention sites, staff were significantly more likely to update existing records (P=.04), generate summaries before (P<.001) or during visits (P=.01), and agree that “the EHR provides useful alerts, and reminders” (P<.01).

Conclusions

Most users perceived the EHR as well accepted, appropriate, and effective for use in low-resource settings despite infrastructure limitation in 25% (22/88) of the sites. The implementation of EHR enhancements can improve the perceived usefulness and use of key functions. Successful scale-up and use of EHRs in small health facilities could improve clinical documentation, care, reporting, and disease surveillance in low- and middle-income countries.
Disease-Course Adapting Machine Learning Prognostication Models in Elderly Patients Critically Ill With COVID-19: Multicenter Cohort Study With External Validation
Authors: Jung Christian , Mamandipoor Behrooz , Fjølner Jesper , Bruno Raphael Romano , Wernly Bernhard , Artigas Antonio , Bollen Pinto Bernardo , Schefold Joerg C , Wolff Georg , Kelm Malte , Beil Michael , Sviri Sigal , van Heerden Peter V , Szczeklik Wojciech , Czuczwar Miroslaw , Elhadi Muhammed , Joannidis Michael , Oeyen Sandra , Zafeiridis Tilemachos , Marsh Brian , Andersen Finn H , Moreno Rui , Cecconi Maurizio , Leaver Susannah , De Lange Dylan W , Guidet Bertrand , Flaatten Hans , Osmani Venet
Published: January 2022

Background

The COVID-19 pandemic caused by SARS-CoV-2 is challenging health care systems globally. The disease disproportionately affects the elderly population, both in terms of disease severity and mortality risk.

Objective

The aim of this study was to evaluate machine learning–based prognostication models for critically ill elderly COVID-19 patients, which dynamically incorporated multifaceted clinical information on evolution of the disease.

Methods

This multicenter cohort study (COVIP study) obtained patient data from 151 intensive care units (ICUs) from 26 countries. Different models based on the Sequential Organ Failure Assessment (SOFA) score, logistic regression (LR), random forest (RF), and extreme gradient boosting (XGB) were derived as baseline models that included admission variables only. We subsequently included clinical events and time-to-event as additional variables to derive the final models using the same algorithms and compared their performance with that of the baseline group. Furthermore, we derived baseline and final models on a European patient cohort, which were externally validated on a non-European cohort that included Asian, African, and US patients.

Results

In total, 1432 elderly (≥70 years old) COVID-19–positive patients admitted to an ICU were included for analysis. Of these, 809 (56.49%) patients survived up to 30 days after admission. The average length of stay was 21.6 (SD 18.2) days. Final models that incorporated clinical events and time-to-event information provided superior performance (area under the receiver operating characteristic curve of 0.81; 95% CI 0.804-0.811), with respect to both the baseline models that used admission variables only and conventional ICU prediction models (SOFA score, P<.001). The average precision increased from 0.65 (95% CI 0.650-0.655) to 0.77 (95% CI 0.759-0.770).

Conclusions

Integrating important clinical events and time-to-event information led to a superior accuracy of 30-day mortality prediction compared with models based on the admission information and conventional ICU prediction models. This study shows that machine-learning models provide additional information and may support complex decision-making in critically ill elderly COVID-19 patients.

Trial Registration

ClinicalTrials.gov NCT04321265; https://clinicaltrials.gov/ct2/show/NCT04321265
Machine Learning–Based Short-Term Mortality Prediction Models for Patients With Cancer Using Electronic Health Record Data: Systematic Review and Critical Appraisal
Authors: Lu Sheng-Chieh , Xu Cai , Nguyen Chandler H , Geng Yimin , Pfob André , Sidey-Gibbons Chris
Published: January 2022

Background

In the United States, national guidelines suggest that aggressive cancer care should be avoided in the final months of life. However, guideline compliance currently requires clinicians to make judgments based on their experience as to when a patient is nearing the end of their life. Machine learning (ML) algorithms may facilitate improved end-of-life care provision for patients with cancer by identifying patients at risk of short-term mortality.

Objective

This study aims to summarize the evidence for applying ML in ≤1-year cancer mortality prediction to assist with the transition to end-of-life care for patients with cancer.

Methods

We searched MEDLINE, Embase, Scopus, Web of Science, and IEEE to identify relevant articles. We included studies describing ML algorithms predicting ≤1-year mortality in patients of oncology. We used the prediction model risk of bias assessment tool to assess the quality of the included studies.

Results

We included 15 articles involving 110,058 patients in the final synthesis. Of the 15 studies, 12 (80%) had a high or unclear risk of bias. The model performance was good: the area under the receiver operating characteristic curve ranged from 0.72 to 0.92. We identified common issues leading to biased models, including using a single performance metric, incomplete reporting of or inappropriate modeling practice, and small sample size.

Conclusions

We found encouraging signs of ML performance in predicting short-term cancer mortality. Nevertheless, no included ML algorithms are suitable for clinical practice at the current stage because of the high risk of bias and uncertainty regarding real-world performance. Further research is needed to develop ML models using the modern standards of algorithm development and reporting.
Diagnostic Performance of an App-Based Symptom Checker in Mental Disorders: Comparative Study in Psychotherapy Outpatients (Preprint)
Authors: Hennemann Severin , Kuhn Sebastian , Witthöft Michael , Jungmann Stefanie M
Published: January 2022

BACKGROUND

Digital technologies have become a common starting point for health-related information-seeking. Web- or app-based symptom checkers aim to provide rapid and accurate condition suggestions and triage advice but have not yet been investigated for mental disorders in routine health care settings.

OBJECTIVE

This study aims to test the diagnostic performance of a widely available symptom checker in the context of formal diagnosis of mental disorders when compared with therapists’ diagnoses based on structured clinical interviews.

METHODS

Adult patients from an outpatient psychotherapy clinic used the app-based symptom checker Ada–check your health (ADA; Ada Health GmbH) at intake. Accuracy was assessed as the agreement of the first and 1 of the first 5 condition suggestions of ADA with at least one of the interview-based therapist diagnoses. In addition, sensitivity, specificity, and interrater reliabilities (Gwet first-order agreement coefficient [AC1]) were calculated for the 3 most prevalent disorder categories. Self-reported usability (assessed using the System Usability Scale) and acceptance of ADA (assessed using an adapted feedback questionnaire) were evaluated.

RESULTS

A total of 49 patients (30/49, 61% women; mean age 33.41, SD 12.79 years) were included in this study. Across all patients, the interview-based diagnoses matched ADA’s first condition suggestion in 51% (25/49; 95% CI 37.5-64.4) of cases and 1 of the first 5 condition suggestions in 69% (34/49; 95% CI 55.4-80.6) of cases. Within the main disorder categories, the accuracy of ADA’s first condition suggestion was 0.82 for somatoform and associated disorders, 0.65 for affective disorders, and 0.53 for anxiety disorders. Interrater reliabilities ranged from low (AC1=0.15 for anxiety disorders) to good (AC1=0.76 for somatoform and associated disorders). The usability of ADA was rated as high in the System Usability Scale (mean 81.51, SD 11.82, score range 0-100). Approximately 71% (35/49) of participants would have preferred a face-to-face over an app-based diagnostic.

CONCLUSIONS

Overall, our findings suggest that a widely available symptom checker used in the formal diagnosis of mental disorders could provide clinicians with a list of condition suggestions with moderate-to-good accuracy. However, diagnostic performance was heterogeneous between disorder categories and included low interrater reliability. Although symptom checkers have some potential to complement the diagnostic process as a screening tool, the diagnostic performance should be tested in larger samples and in comparison with further diagnostic instruments.
Explain the Effect of Role Conflict and Stress on Entrepreneurial Performance in Digital Businesses
Authors: Shahbandi Mohammadali
Published: January 2022

Role conflict is one of the most important causes of job stress and reduced attachment and job satisfaction. Role conflict occurs when it is impossible or completely impossible to comply with one set of job requirements by accepting another set of job requirements. The main purpose of this study is to investigate the effect of stress and role conflict on entrepreneurial performance among digital businesses. The research method in this article is descriptive-analytical and survey surveys between the statistical community (employees and managers and activists of digital businesses) and data analysis using SPSS software. The results showed that job stress and role conflict have a significant inverse effect on entrepreneurial performance, and there is a significant relationship between job stress and role conflict.
Muertes de mujeres centroamericanas en México y su compleja identificación en las estadísticas vitales
Authors: Jasso Vargas Rosalba
Published: January 2022

En este artículo se revisan algunos conceptos relacionados con el vínculo entre género, migración y violencia con el fin de comprender la condición de vulnerabilidad y los riesgos que enfrentan las mujeres a su paso por México; en especial, el peligro de muerte. El objetivo es reflexionar y analizar las principales debilidades de las estadísticas de mortalidad del Instituto Nacional de Estadística y Geografía (INEGI) en la identificación de decesos de migrantes en tránsito por México, y en particular de mujeres centroamericanas. Por medio de la revisión de actas de defunción del Registro Civil en cinco municipios de la frontera sur, el artículo señala cómo la incorporación y desagregación de algunas variables en los registros del INEGI contribuiría a la caracterización de decesos de personas extranjeras.
Enfermera de Práctica Avanzada en Chile: identificando barreras y oportunidades para el ejercicio del rol
Authors: Urrutia-Egaña M.J. , Perucca-Gallegos D. , Valdés-Martinic C.F.
Published: January 2022

Introducción: La implementación del rol de Enfermería de Práctica Avanzada (EPA) se identifica como una estrategia que permite mejorar el acceso a la atención de la salud, en busca de salud para todos. Dicha estrategia se lleva a cabo por un profesional de enfermería acreditado, especialista clínico y de atención directa, quien formula diagnósticos, realiza tratamientos y seguimiento a las personas.
Objetivo: Reflexionar acerca de las barreras y oportunidades para incorporar el ejercicio profesional de enfermería de práctica avanzada en Chile.
Desarrollo: El acceso a la salud y la cobertura universal son elementos mínimos para lograr la salud de todos. Por ello, se han hecho esfuerzos para alcanzar estos requisitos mediante el fortalecimiento de la atención primaria de salud y el desarrollo de profesionales no médicos como enfermeras/os de práctica avanzada. Desde la Organización Panamericana de la Salud se realizan acciones para promover este rol; sin embargo, en el establecimiento de la enfermería de práctica avanzada aún se identifican barreras, entre ellas, la actual legislación del código sanitario y la escasa oferta académica para su formación, elementos que no dejan de estar en la discusión pública.
Conclusiones: Se requiere de un esfuerzo conjunto para generar un contexto que permita la implementación del rol de enfermera de práctica avanzada en Chile, con la finalidad de disminuir las brechas de acceso y cobertura, lo que se espera mejore la calidad y equidad de salud de todos los chilenos.
Imagens-lembrança e identidades no cinema intercultural de Tila Chitunda
Authors: Mendonça Fernanda Mendes de
Published: January 2022

Este artigo propõe uma reflexão sobre a presença das imagens de arquivo familiar apresentadas no curta FotogrÁFRICA, de Tila Chitunda, que nos encaminha a pensar junto ao conceito deleuziano de imagem-lembrança. Fazemos esta análise compreendendo o filme como produto de um cinema intercultural, que se situa na intersecção de dois regimes culturais de conhecimento, neste caso Brasil e Angola, países da rota do Atlântico Negro. Diante dessas imagens, acessamos o que é visível e virtual e exploramos seus aspectos paradoxais. Ao tempo em que se apresentam como registros familiares, as fotografias também expõem a opressão colonial e violência cometida contra identidades e individualidades.
A arte brasileira não se resume ao eixo Rio de Janeiro-São Paulo: sotaques poéticos do nordeste por uma urgente história da arte
Authors: Bruno Eduardo , Lima João Paulo , Castro Waldírio
Published: January 2022

Esse texto, a partir da apropriação do termo sotaque do campo da linguística, aposta na dimensão plural da produção artística contemporânea do/no nordeste brasileiro, com o objetivo de estabelecer rupturas na/com a história da arte nacional, tradicionalmente narrada a partir do eixo Rio de Janeiro/São Paulo. Para tal, divido em três tópicos, que podem ser lidos na ordem que se preferir, o texto costura reflexões acerca do lugar do nordeste no sistema de arte nacional, com debates históricos, poéticos, estéticos, políticos e sociais que se estabelecem entre as regiões nordeste e sudeste. Sendo assim, cada parte do texto, mobiliza um escopo de referências teóricas e artísticas, provocando a ideia de sotaques poéticos para demarcar territórios propositivos para a formulação de muitos (outros) mapas (im)possíveis da arte brasileira.
Miodrag Pešić — a Recognized Serbian Connoisseur of Esenin and a Talented Translator
Authors:   Lomonosov Moscow State University, Firsov Evgeniy F.
Published: January 2022

Pešić’s stay in Moscow (May 1917 — July 1920) and his studies at Moscow State University coincided with the period of the formation and rise of the imaginistic movement, which Miodrag Pešić witnessed first-hand. Thanks to Balmont and Baltrushaitis, Pešić’s acquaintance with Russian poets contributed to his comprehension of the contemporary literary process. In Serbia (starting from the middle of the 1920’s) Pešić was a leading researcher of Esenin’s life and creative work, his interest in the imaginists’ works increasing. For the first time the author reveals the translation of “A Novel Without Lies” by A. Marienhof in 1941. Translations of the works of the main representatives of imaginism appeared in Belgrade and Sarajevo. The article considers perception of imaginism and Pešić’s effort to popularise the imaginists under Serbian and Yugoslavian conditions. The author gives periodization of the study of Esenin’s and the imaginists’ creative work, and shows Pešić’s talent of the translator.
Esenin in Estonia and Latvia (1920–1927)
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Subbotin Sergey I.
Published: January 2022

The article provides a general overview of materials that appeared in the press of Estonia and Latvia from the first mention of the name of S. A. Esenin to materials caused by the tragic death of the Russian poet. The authors of a significant number of responses were journalists and cultural ideologists who visited Soviet Russia and got an idea of the literary and cultural life of that time. Some of them got acquainted with S. A. Esenin. Special attention in the article is paid to the translations of Esenin’s works and memoirs about him.
A incorporação do conceito de segregação na avaliação dos efeitos das políticas para redução da privação humana no Brasil
Authors: Cruz Marcelo Karloni
Published: January 2022

Objetiva o trabalho dissertar sobre importância do conceito de segregação, na avaliação das políticas para redução da privação humana. Argumenta que a produção de contra hegemonias discursivas por formuladores e avaliadores da ação do Estado brasileiro na história é de fundo uma ação política. Demonstra em seguida a evolução de indicadores da privação humana no Brasil, Recife/PE e Natal/RN, destacando a disparidade entre a redução da pobreza e das desigualdades entre 1991 e 2010. O trabalho tece por fim considerações acerca do conceito de segregação para concluir que sua incorporação nas ações de avaliação implicaria na ampliação do poder político e usufruto das cidades por parte dos grupos-alvo das ações do Estado brasileiro para redução da pobreza e desigualdade.
As funções reservadas ao Município de Cariré/CE no Plano de Desenvolvimento Urbano Integrado da Região Metropolitana de Sobral (PDUI/RMS)
Authors: Rodrigues Antonio Veiga , Teles Glauciana Alves
Published: January 2022

A Região Metropolitana de Sobral (RMS) foi a terceira região metropolitana institucionalizada no Estado do Ceará, em dezembro de 2016. Em 2018, foi apresentado o relatório final do Plano de Desenvolvimento Urbano Integrado (PDUI), trazendo as diretrizes para o desenvolvimento urbano e regional da unidade territorial. A RMS é composta por 18 municípios, sendo a cidade de Sobral sua sede metropolitana, além de ser considerada um dos principais centros urbanos cearenses. Nesse contexto, Cariré, um dos dezoito municípios destaca-se possui características territoriais particulares que o evidenciam de suma importância na gestão territorial da RMS, possuindo as funções logística e comercial. O artigo apresenta uma análise das funções de Cariré no contexto da reestruturação territorial da RMS.
Tecnologias Sociais e produção de alimentos em municípios do Sudoeste Baiano. Conquistas e desafios na garantia da soberania alimentar camponesa.
Authors: Almeida Eliane Pereira de , Corrêa Marcus Metri , Andrade Luciano Pires de
Published: January 2022

Este artigo objetiva analisar como se dá a produção de alimentos pelas famílias camponesas no Sudoeste Baiano, a partir do uso e apropriação das estruturas hídricas do Programa “Por Uma Terra e Duas Águas” (P1+2). Para tanto, delimitou-se o estudo em quatro municípios: Anagé, Bom Jesus da Serra, Cândido Sales e Poções. A metodologia adotada inclui a revisão de literatura, a pesquisa documental, o levantamento de dados primários e secundários, e entrevistas semiestruturadas, realizadas remotamente por conta da pandemia. Os resultados obtidos evidenciam que as tecnologias sociais do P1+2 exercem papel substancial para o cultivo de alimentos que compunham a dieta alimentar das famílias camponesas. No entanto, o período de estiagem ainda se apresenta como desafio para uma produção contínua.
Encontro da multiplicidade na sobremodernidade nas geofotografias do ser-mangue na ZEIS — Ilha de Deus, Recife-PE
Authors: Silva Filho Luiz Carlos
Published: January 2022

Percorre por cidades existentes, a partir de uma visão sobremoderna, podemos encontrar vestígios de espaços colocados em uma solidão gerida pelo coletivo hegemônico. Produzindo não-lugares, espaços vazios e —como identificamos— espaços esvaziados ou lugares-assignificativos. Sob esse ponto de vista, o presente trabalho visa encontrar pela razão esquizoanalítica n-1 as multiplicidades de vínculos existentes na captura da paisagem cristalizada e materializada na representação visual-documental dos espaços esvaziados promovidos pela sobremodernidade na ZEIS - Ilha de Deus. Utilizamos a etnocartografia e a geofotografia como possibilidade metodológica para compreender e dar visibilidade às multiplicidades existentes. Encontramos a existência transitória de corpora em multiplicidade na Ilha de Deus. O uno torn-se múltiplo em um lugar ressignificado, passando de lugares assignificativos à um lugar significativo.
Essä
Authors: Alexander Mood
Published: January 2022

Essä inlämning
From atomic physics, to upper-atmospheric chemistry, to cosmology: A “laser photometric ratio star” to calibrate telescopes at major observatories
Authors: Albert Justin , Budker Dmitry , Sadeghpour Hossein
Published: January 2022

This Research Highlight showcases the two Research Papers entitled, A
precise photometric ratio via laser excitation of the sodium layer – I.
One-photon excitation using 342.78 nm light,
https://doi.org/10.1093/mnras/stab1621 and A precise photometric
ratio via laser excitation of the sodium layer – II. Two-photon
excitation using lasers detuned from 589.16 nm and 819.71 nm resonances,
https://doi.org/10.1093/mnras/stab1619.
Metabolome and transcriptome profiling reveals that terpenoid biosynthesis dominates the growth and development of Sanghuangporus baumii
Authors: Liu Zengcai , Wang Shixin , Liu Ruipeng , Tong Xinyu , Li Yawei , Wang Xutong , Zou Li
Published: January 2022

Sanghuangporus baumii is a traditional medicinal fungus that
produces pharmacological terpenoids, but natural resources are
insufficient for applications, and growth and development mechanisms are
poorly understood. Combining metabolomic and transcriptomic analyses, we
identified four terpenoid hormones and a central gene isopentenyl
diphosphate isomerase (IDI) involved in growth and development. The
importance of the four terpenoid hormones was further confirmed by
exogenous hormones addition, we found that Cis-Zeatin (CZ) plays a major
role in the mycelia stage, Trans-Zeatin (TZ) and Gibberellin A4 (GA4)
are important in the primordia stage, GA4 is crucial for the fruiting
bodies stage, and Abscisic Acid (ABA) may be a marker of maturity.
Later, hormone content determination and qRT-PCR were used to verify the
growth and development mechanism, and finally it was confirmed that
IDI gene affects the content of terpenoid hormones content by
regulating the transcript level of terpenoid biosynthesis genes, thus
affecting the morphological changes of S. baumii. Our results
illuminate the growth and development mechanisms of S. baumii,
and may promote the breeding and utilisation of high-quality varieties.
Single low-dose exposure to cow's milk at diagnosis accelerates cow's milk allergic infants' progress on a milk ladder programme
Authors: Hourihane Jonathan O’B , M Yvonne d’Art , Forristal Lisa , Byrne Aideen , Fitzsimons John , Ree Ronald Van , DunnGalvin Audrey
Published: January 2022

Background Cow’s milk protein allergy (CMPA) is one of the most
common food allergies in infancy. Most infants with CMPA tolerate baked
milk from diagnosis and gradually acquire increased tolerance.
Nevertheless, parents often display significant anxiety about this
condition and a corresponding reluctance to progress with home
introduction of dairy due to concerns about possible allergic reactions.
Objective: To evaluate the impact on gradual home introduction
of foods containing cows milk after a supervised, single low dose
exposure to whole milk at time of diagnosis. Methods Infants
less than 12 months old, referred with suspected IgE-mediated cow’s milk
allergy were recruited to an open-label randomised, controlled trial of
intervention - a single dose of fresh cow’s milk, using the validated
dose of milk that would elicit reactions in 5% of CMPA subjects - the
ED – vs routine care. Both groups implemented graded
exposure to CM (using the 12 step MAP Milk Tolerance Induction Ladder),
at Home. Parents completed food allergy quality of life and State and
Trait Anxiety Inventories (STAI). Main outcome measures were milk ladder
position at 6 months and 12 months post randomisation. Results:
Sixty patients were recruited, 57 (95%) were followed to 6 months. By 6
months 27/37 (73%) intervention subjects had reached step 6 or above on
the milk ladder compared to 10/20 (50%) control subjects (p=0.048). By
6 months 11/37 (30%) intervention subjects had reached step 12 (ie
drinking unheated cow’s milk) compared to 2/20 (10%) of the controls
(p=0.049). Twelve months post randomisation 31/36(86%) of the
intervention group and 15/19(79%) of the control group were on step 6
or above. However, 24/37 (65%) of the intervention group were at step
12 compared to 7/20 (35%) of the control group (p=0.03). Maternal STAIs
were significantly associated with their infants’ progress on the milk
ladder and with changes in skin prick test and spIgE levels at 6 and 12
months. Conclusion This study demonstrates the safety and
effectiveness of introduction of baked milk implemented immediately
after diagnosis of cows milk allergy in a very young cohort. A
supervised single dose of milk at the ED
significantly accelerates this further, probably by giving parents the
confidence to proceed. Maternal anxiety generally reflects infants’
progress towards completion of the milk ladder, but pre-existing high
levels of maternal anxiety are associated with poorer progress.
Rheological, textural and sensorial properties of mayonnaise fortified with Asian sea bass bio-calcium
Authors: Wijayanti Ima , Prodpran Thummanoon , Sookchoo Pornsatit , Nirmal Nilesh , Zhang Bin , Balange Amjad , Benjakul Soottawat
Published: January 2022

Fortification of Asian sea bass bone bio-calcium (ASBC) at different
levels (0-10%) into mayonnaise was carried out. Firmness, consistency
and cohesiveness of mayonnaise were augmented with increasing ASBC
levels (P<0.05). ASBC raised lightness (L*) and total color
difference (E*), but decreased a* and b*-values of mayonnaise in a dose
dependent manner (P<0.05). Higher G’, G”, viscosity and shear
stress value were observed in mayonnaise sample added with ASBC.
However, lower acceptability was attained when mayonnaise was added with
ASBC at level higher than 2.5% due to fishy odor and grittiness
perceived by panelists. Ultrasonicated ASBC (U-ASBC) was prepared using
pulse mode at 70% amplitude for different times (5, 10 and 15 min) in
the presence of hexane. Based on acceptability, mayonnaise added with
U-ASBC using ultrasonication time of 15 min was selected. Reduced
particle size with lowered volatile compounds was attained in U-ASBC
powder than that of ASBC. Mayonnaise added with 7.5% U-ASBC (M-UBC-7.5)
had higher viscosity with lower creaming and thermal creaming index
(P<0.05) compared to the control and that added with 2.5%
ASBC (M-BC-2.5). Optical microscopic images showed that denser and
smaller droplet size was observed for M-BC-2.5 and M-UBC-7.5 than
control. The lowest moisture, fat and carbohydrate contents were
attained for M-UBC-7.5 with the higher protein, ash and calcium content
(P<0.05), compared to control and M-BC-2.5. Fortification of
mayonnaise with ASBC at 2.5% or U-ASBC at 7.5% could increase calcium
content by 54 or 174 times, respectively, without any sensorial changes.
Identificação de cianobactérias na Lagoa Salgada por abordagem metagenômica, Rio de Janeiro, Brasil
Authors: Almeida Thiago Corrêa de , Fonseca Rodrigo Jardim Monteiro , Moura Priscila Gonçalves , Carvajal Elvira , Kotowski-Filho Nelson Peixoto , Sotero-Martins Adriana
Published: January 2022

A Lagoa Salgada é um corpo aquático hipersalino costeiro localizado no norte do Estado do Rio de Janeiro e reconhecido pela presença de estromatólitos. As cianobactérias são os principais produtores primários dessas estruturas em lagoas hipersalinas costeiras. O objetivo do estudo foi identificar as cianobactérias presentes na Lagoa Salgada por meio da metagenômica. O material genético obtido de uma amostra de água coletada no mês de junho de 2019 foi submetido ao sequenciamento pelo método shotgun. Os dados metagenômicos foram analisados utilizando o pipeline MetaWrap versão 1.3 para identificação das cianobactérias e dos processos biológicos. O gênero Synechococcus apresentou maior abundância correspondendo por 64,3% das cianobactérias identificadas, seguidos por Synechocystis (23,6%), Geminocystis (2%) e Calothrix (1,8%). As espécies mais abundantes foram Synechococcus sp. RS9909 (46,7%), Synechocystis sp. PCC 6714 (16,4%), Synechococcus sp. WH 8101 (9,2%), Synechocystis sp. CACIAM 05 (4,3%). Foram identificados 33 processos biológicos associados aos genes presentes na amostra. A Lagoa Salgada apresenta uma ampla diversidade de cianobactérias em seu ecossistema aquático ainda pouco explorado, fundamentando a necessidade de proteção e preservação deste ambiente lagunar.
Categorization of extinction risk of Discocactus species
Authors: Cruz Anny Bianca Santos , Reis Daniel Oliveira , Fabricante Juliano Ricardo
Published: January 2022

The present study aimed to update the categorization of the extinction risk of Discocactus bahiensis Britton & Rose and Discocactus zehntneri Britton & Rose, endemic Cactaceae species from Northeastern Brazil. The georeferenced species occurrence points were obtained from the online databases speciesLink and Global Biodiversity Information Facility (GBIF). Polygons were traced using these points, being gridded with 4 km² cells and virtually divided in half (2 km²). Afterwards, the cells occupied by the species were counted in order to obtain their occupation areas. The species D.bahiensis presented 17 records and an occupation area of 32 km², while D.zehntneri presented 15 records and an occupation area of 24 km². The sites where the species are found present different factors of anthropic pressure. Thus, the species D.bahienses and D.zehntneri were categorized as “Endangered”, according to the B2biiicii criteria.
First record of Astrocaryum G. Mey. (Arecaceae) for Ceará, Northeastern Brazil
Authors: Rodrigues Leonardo De Sousa , De Sousa Izaias Carvalho , Sousa Santos Francisco Diego , De Souza Elnatan Bezerra
Published: January 2022

We document here the first record of Astrocaryum G.Mey. for Ceará State, Brazil. A. vulgare Mart., a species formerly known only to the Brazilian states of Amapá, Pará, Tocantins, Goiás, and Maranhão, was collected in areas of the Coastal Vegetation Complex, whose floristic composition is influenced by both the Caatinga and Cerrado domains. This finding expands our knowledge on the geographic distribution of this species in Brazil, contributing to its conservation and to future biogeographic studies. We present ecological, morphological and taxonomic data, a distribution map, photographs and illustrations, and update its conservation status.
Magnetohydrodynamic Flow and Heat Transfer Characteristics in Micropolar-Casson Fluid over a Stretching Surface with Temperature-dependent Material Properties.
Authors:   Dept. of Maths & Statistics Federal Polytechnic Ilaro, Nigeria, Fatunmbi E.O. , Akanbi O.O.
Published: January 2022

The current investigation communicates the flow and heat transfer characteristics of an electrically conducting micropolar-Casson fluid over a two-dimensional stretching surface with variable thermal conductivity and viscosity. Thermal radiation, viscous dissipation and heat source effects are also accounted for in the energy equation. The formulated equations of flow and heat transfer are converted from partial to ordinary differential equations using suitable similarity transformations while the dimensionless equations are solved by Runge-Kutta Fehlberg integration scheme. The effects of the physical parameters are publicized through graphs and validated by related published studies in the limiting situations. It is found from the investigation that there is accelerated flow due to the material micropolar term whereas the presence of Casson fluid and magnetic field terms decelerate the velocity. Besides, the surface temperature improves with a rise in the Casson fluid term, Eckert number and thermal conductivity parameter whereas the trend is reversed for micropolarity influence. Keywords: Micropolar-Casson fluid; Magnetohydrodynamic, Variable viscosity; Variable thermal conductivity;Viscous dissipation
Challenges of Autonomy on Effective Local Government in Nigeria.
Authors:   Dept of General Studies Lagos State Polytechnic, Ikorodu Lagos State, Nigeria, Aderogba A.
Published: January 2022

The focus of this study is to examine the relationship between autonomy and effectiveness of local government in Nigeria. The administrative structure for local governance has always existed in one form or the other since colonial period. However, the poser is how autonomous are they as a unit of government and to what extent are they effective. This study relying on available secondary data, adduced that local governments have constitutional responsibilities, its autonomy is greatly eroded by other higher tier governments, and that lack of autonomy impedes its effectiveness. Way forward suggested include, constitutional reforms, limited role for both state and federal governments and financial autonomy for effectiveness. Keywords: Local government, Autonomy, Effectiveness, Efficient-service, Decentralization
Projeto político-pedagógico: ideologia e utopia
Authors: Rocha Maria Zélia Borba , Moraes Shayane Cristina
Published: January 2022

O projeto político-pedagógico é um documento de gestão escolar, obrigatório para as escolas públicas, estabelecido na legislação federal brasileira. O objetivo da pesquisa realizada foi desvelar a ideologia e a utopia subjacentes aos projetos político-pedagógicos. A pesquisa empírica de metodologia mista foi realizada em dois períodos: 2010-2012 e 2018-2019, e empregou, como método quantitativo, o método indutivo, e na base qualitativa, a Hermenêutica de Profundidade. O método indutivo forneceu os critérios de coorte na coleta dos dados e a Hermenêutica de Profundidade propiciou o desvelamento da ideologia e da utopia ocultos nos conteúdos dos projetos político-pedagógicos. A análise qualitativa, por intermédio da Hermenêutica de Profundidade, recorreu aos conceitos de ideologia e de utopia na perspectiva mannheimiana. A análise conseguiu identificar quatro componentes ideológicos e um componente utópico.
Coordenação pedagógica no âmbito da política nacional de formação de professores (2007-2016): a experiência do Programa Nacional Escola de Gestores
Authors: Oliveira Breynner Ricardo de , Coelho Jianne Ines Fialho
Published: January 2022

Este artigo analisa a identidade e o trabalho do coordenador pedagógico (CP) na gestão cotidiana das escolas, a partir do Curso de Especialização em Coordenação Pedagógica, no âmbito do Programa Nacional Escola de Gestores ofertado pela Universidade Federal de Ouro Preto. O CP tem um papel fundamental na organização e gestão da escola. Por ser considerado um formador de formadores, seu trabalho é decisivo para que esse processo se efetive, além de fortalecer a equipe gestora. Os dados que subsidiam a discussão advêm da codificação de 273 Trabalhos de Conclusão de Curso desenvolvidos pelos cursistas durante a vigência do Programa. As análises revelam que os cursistas compreenderam e problematizaram as questões relativas à gestão escolar e sua atuação, associadas à identidade da profissão. O artigo também denuncia o desmonte da Política Nacional de Formação de Professores e, consequentemente, a interrupção do PNEG, a partir do golpe parlamentar de 2016.
Os desafios ao tornar-se professor/a: uma análise da profissionalidade docente na educação infantil
Authors: Palhano Tânia Rodrigues , Correia Lindinalva Alcântara , Neves Elidiana Oliveira  das
Published: January 2022

O texto consiste em discutir, a partir de uma pesquisa com professores/as da Educação Infantil, os desafios ao tornar-se professor/a, vislumbrando a profissionalidade docente. Assim, essa investigação examinou fatores sociodemográficos relacionados a faixa etária, vínculo empregatício e formação. Foi realizada com as professoras que atuam nessa etapa da educação, em dois Centros de Referência em Educação Infantil-CREI, a partir de entrevista semiestruturada. Contou com a participação de 20 docentes da Rede Pública Municipal de Ensino de João Pessoa - Paraíba. Na análise dos dados obtidos, utilizamos a análise de conteúdo, com a técnica da análise temática. Os resultados evidenciaram que os/as docentes apresentam satisfação com a formação profissional inicial, e que um dos maiores desafios após a graduação é retornar à academia para estudar e manter-se ativo num processo de formação permanente. Com os resultados, pode-se pensar na ampliação das vagas ofertadas nos cursos de pós-graduação na área da educação, bem como o incentivo aos estudantes egressos da graduação, no sentido da sua permanência enquanto profissionais pesquisadores/as.
On the development of cognitive skills and behavior regulation of five- and six-year-old children
Authors: Dedyukina Marfa , Ivanova Maria , Popova Lyudmila , Semenov Yuri
Published: January 2022

The article analyzes the development of cognitive skills and behavior regulation in five- and six-year-old children. The authors outlined the specifics of the development of cognitive skills and behavior regulation of preschoolers. In Block 1, the authors measured the level of intellectual development. Block 2 included diagnostics of cognitive skills development. In Block 3, the authors evaluated children’s understanding of emotions and their own and other people’s thoughts and feelings using the diagnostic methods developed for preschool children and adapted by A.N. Veraksa, D.A. Bukhalenkova, and O.V. Almazova. The authors widely used the NEPSY-II neuropsychological diagnostic complex’s subtests to assess the mental development of children aged 3 to 16. The authors devised the norms for developing cognitive skills and behavior regulation adapted for a particular Russian region. The obtained results of the study can be used as the basis for planning correctional and developmental activities with preschool children.
On distance dominator packing coloring in graphs
Authors: Ferme Jasmina , Stesl Dasa
Published: January 2022

Let G be a graph and let S = (s1,s2,..., sk) be a non-decreasing
sequence of positive integers. An S-packing coloring of G is a mapping c :
V(G) ? {1, 2,..., k} with the following property: if c(u) = c(v) = i,
then d(u,v) > si for any i ? {1, 2,...,k}. In particular, if S = (1,
2, 3, ..., k), then S-packing coloring of G is well known under the name
packing coloring. Next, let r be a positive integer and u,v ? V(G). A
vertex u r-distance dominates a vertex v if dG(u, v)? r. In this paper, we
present a new concept of a coloring, namely distance dominator packing
coloring, defined as follows. A coloring c is a distance dominator packing
coloring of G if it is a packing coloring of G and for each x ? V(G) there
exists i ? {1,2, 3,...} such that x i-distance dominates each vertex
from the color class of color i. The smallest integer k such that there
exists a distance dominator packing coloring of G using k colors, is the
distance dominator packing chromatic number of G, denoted by ?d?(G). In
this paper, we provide some lower and upper bounds on the distance dominator
packing chromatic number, characterize graphs G with ?d?(G) ? {2,3}, and
provide the exact values of ?d?(G) when G is a complete graph, a star, a
wheel, a cycle or a path. In addition, we consider the relation between
?? (G) and ?d?(G) for a graph G.
The Cesàro operator on weighted Bergman Fréchet and (LB)-spaces of analytic functions
Authors: Kızgut Ersin
Published: January 2022

The spectrum of the Ces?ro operator C is determined on the spaces which
arises as intersections Ap ?+ (resp. unions Ap ?-) of Bergman spaces Ap?
of order 1 < p < 1 induced by standard radial weights (1-|z|)?, for 0 < ?
< 1. We treat them as reduced projective limits (resp. inductive limits) of
weighted Bergman spaces Ap?, with respect to ?. Proving that these spaces
admit the monomials as a Schauder basis paves the way for using
Grothendieck-Pietsch criterion to deduce that we end up with a non-nuclear
Fr?chet-Schwartz space (resp. a non-nuclear (DFS)-space). We show that C is
always continuous, while it fails to be compact or to have bounded inverse
on Ap ?+ and Ap ?-.
Multi-parameter setting (c,α) means with respect to one dimensional Vilenkin system
Authors: Gát György , Tilahun Anteneh
Published: January 2022

We prove that the maximal operator of the (C,?n)-means of the one
dimensional Vilenkin-Fourier series is of weak type(L1, L1). Moreover, we
prove the almost everywhere convergence of the (C,?n) means of integrable
functions (i.e. ? ?n n f ? f ), where n ? N?,q and n ? 1 for f ? L1(Gm),
Gm is a bounded Vilenkin group, for every sequence ? = (?n), 0 < ?n < 1.
A tensor product of Kantorovich-Stancu type operators with shifted knots and their kth order generalization
Authors: Baxhaku Behar , Shukla Rahul , Agrawal P.N.
Published: January 2022

In this paper, we introduce a tensor product of the Stancu-Kantorovich type
operators defined by I??z [11]. The rate of convergence of these
operators is obtained in terms of the modulus of continuity and the Peetre?s
K-functional. Further, we consider a generalization of the above operators
via Taylor?s polynomials and examine their approximation behavior. Some
applications of these two dimensional generalized Stancu-Kantorovich type
polynomials are also discussed. Finally, we present some numerical examples
and illustrations to show the convergence behavior of the operators under
study using MATLalgorithms.
Assessment of reliability in orthodontic literature:
Authors: Donatelli Richard E. , Park Ji-Ae , Alghamdi Yasser Murdi Abdullah , Pandis Nikolaos , Lee Shin-Jae
Published: January 2022

Objectives

To map the statistical methods applied to assess reliability in orthodontic publications and to identify possible trends over time.

Materials and Methods

Original research articles published in 2009 and 2019 in a subset of orthodontic journals were downloaded. Publication characteristics, including publication year, number of authors, single vs multicenter study, geographic origin of the study, statistician involvement, study category, subject category, types of reliability assessment, and statistical methods applied to assess reliability, were recorded. Descriptive statistics, Chi-square tests, and logistic regression analyses were performed to investigate associations between reliability analysis and study characteristics.

Results

A total of 768 original research articles were analyzed. The most prevalent study category was observational (69%) with a statistician involved in 16% of studies. Overall, reliability was assessed in 47% of studies, and the most frequent methods applied to assess reliability were intraclass correlation coefficients or kappa statistics (60.4%). The odds of applying appropriate methods were greater in 2019 than in 2009 (odds ratio [OR]: 2.43; 95% confidence interval [CI]: 1.75, 3.37; P < .001). Involvement of a statistician resulted in greater odds of applying appropriate methods compared to no statistician involvement (OR: 1.88; 95% CI: 1.23, 2.87; P < .01).

Conclusions

Over the past decade (2009 vs 2019), reliability assessment became more common in the orthodontic literature, and studies applying correct statistical methods to assess reliability significantly increased. This trend was more apparent in studies that involved a statistician, which may highlight the role of the statistician.