bluuebunny/crossref_metadata_2025 huggingface dataset:
PREBANDINGAN STABILITAS ASPAL MENGGUNAKAN AGREGAT KASAR BATU BELAH DAN BATU GAMPING
Authors: Guncoro Agung , Ridwan Ahmad , S.P Yosef Cahyo , Candra Agata Iwan
Published: February 2020

Temperature is one of the factors that can cause damage to the road, especially on inter-city roads between provinces which in fact are lanes with heavy traffic and are traversed by heavily loaded vehicles. So that besides the pressure due to the burden of the vehicle itself also from the influence of temperature, both the weather temperature, the temperature of the vehicle engine. So from that it is necessary to further study what if the pavement layer is tested with different immersion temperatures and as a comparison used economical alternative aggregates namely limestone. The purpose of this goal is to see the results of a comparison between the use of limestone aggregates with split stones, which can survive the effects of deformation due to changes in temperature. The results showed that the use of limestone material has more strength than temperature changes compared to the use of split stone aggregates with results in changes in the value of stability where the value of the rock changes from 1346Kg to 1238Kg while the limestone values from 1447Kg to 1364Kg . This proves that limestone is more resistant to deformation due to the influence of temperature.Adanya perubahan suhu yang tidak menentu menyebabkan perubahan kekuatan pada lapis perkerasan. Suhu merupakan salah satu faktor yang dapat menyebabkan terjadinya kerusakan pada jalan, apalagi pada jalan antar kota antar provinsi yang notabene jalur dengan lalu lintas padat dan dilalui oleh kendaraan yang bermuatan berat. Sehingga disamping adanya tekanan akibat beban kendaraan itu sendiri juga dari pengaruh suhu, baik itu suhu cuaca, suhu dari mesin kendaraan. Maka dari itu perlu adanya kajian lebih lanjut bagaimana jika pada lapis perkerasan tersebut diuji dengan suhu perendaman yang berbeda serta sebagai perbandingan digunakan agregat alternatif yang ekonomis yakni batu gamping. Maksud tujuan ini adalah melihat hasil perbandingan antara penggunaan agregat batu gamping dengan batu belah, mana yang bisa bertahan dari pengaruh deformasi akibat adanya perubahan suhu. Dari hasil penelitian didapatkan hasil bahwa penggunaan material batu gamping lebih memiliki kekuatan terhadap adanya perubahan suhu dibandingkan penggunaan agregat batu belah dengan hasil pada perubahan nilai stabilitasnya dimana pada batu belah nilai stabilitasnya berubah dari 1346Kg menjadi 1238Kg sedangkan pada batu gamping pada nilai stabilitas dari 1447Kg menjadi 1364Kg. Ini membuktikan bahwa bahwa batu gamping lebih tahan terhadap deformasi akibat pengaruh suhu.
Remediasi Miskonsepsi Mahasiswa Calon Guru Fisika Pada Materi Mekanika Melalui Penerapan Model pembelajaran Inkuiri dan Creative Problem Solving
Authors: Nurhidayat Iqbal , Nana
Published: February 2020

: This research was conducted to identify misconceptions of students of Physics education related to the material "Mechanics" by applying the Inquiry model and Creative Problem Solving (CPS) model. The research was conducted by using the literature study method. In line with this, this research was conducted on students majoring in Physics education. This study aims to (1) determine the level of misconceptions that occur in students of the Department of Physics Education (2) determine the effectiveness of the Creative Problem Solving Model to reduce the level of misconceptions that occur in physics education students
Sistem Pakar Diagnosa Kerusakan Playstation2 Berbasis Web Dengan Metode Forward Chaining
Authors: Sanjaya Ludfi , Butar Belsana Butar
Published: February 2020

Abstract - Playstation2 is the best console of all time and has a major influence on the development of video games. So from that playstation2 until now still in demand in the community in all the game lovers. Basically the problem of damage to playstation2 is the most common case found in playstation2 and private rental employers who have playstation2. This damage requires fast and correct handling, as it can be quite detrimental to playstation2 rental entrepreneurs. Current technological advances to facilitate the work of man, because nowadays we can create an artificial intelligence that one of them called expert systems. For the development of expert systems requires hardware (hardware) such as a monitor, a processor, a minimum of 214 GB hard drive, 320 GB of memory, mouse and keyboard. Perangkat (software) consists Adove CS8 Dreamweaver, MySQL, XAMPP, Browser such as Mozilla. This application was designed with a web and an attractive appearance that can be used online for consultation. The results of this research is the application of playstation2 damage diagnosis expert system based on the indication symptoms of playstation2 problems.

Keyword: Expert System, Forward Chaining, Playstation2 Diagnose, Web Based
Social Justice and Dietetic Education: Are We Preparing Practitioners to Lead?
Authors: Brady Jennifer
Published: February 2020

Purpose: To explore dietetic practitioners’ perceptions of their education and training in the knowledge, skills, and confidence to understand social justice issues and to engage in socially just dietetic practice and social justice advocacy.

Methods: An online semi-qualitative survey sent to Canadian dietitians.

Results: Most respondents (n = 264; 81.5%) felt that knowledge- and skill-based learning about social justice and social justice advocacy should be a part of dietetic education and training. Reasons given by respondents for the importance of social justice learning include: client-centred care and reflexive practice, effecting change to the social and structural determinants of health, preventing dietitian burnout, and relevance of the profession. Yet, over half of respondents either strongly disagreed or disagreed that they were adequately prepared with the knowledge (n = 186; 57.4%), skills (n = 195; 60.2%), or confidence (n = 196; 60.5%) to engage in advocacy related to social justice concerns. Some questioned the practicality of adding social justice learning via additional courses to already full programs, while others proposed infusing a social justice lens across dietetic education and practice areas.

Conclusions: Dietetic education and training must do more to prepare dietitians to answer calls for dietitians to engage in social justice issues through practice and advocacy.
THE EFFECT OF SPHEROIDAL WEATHERING ON THE PYSICO-MECHANICAL PROPERTIES OF TROPICAL GRANITE BOULDER
Authors: Md Dan Mohd Firdaus
Published: February 2020

The aim of this research is to investigate the effect of spheroidal weathering on the physico-mechanical properties of in situ granite boulder in tropical environment. This research was conducted to gain more understanding due to lack of study related to this topic especially on tropical boulder in completely weathered zone. A number of 34 in situ granite boulders that naturally formed in completely weathered zone were selected and investigated from two quarries located in Southern Johor, Malaysia. Classification of weathering grade was conducted on the material surrounding boulder based on discolouration, degree of friability and texture characteristics as suggested by ISRM(1). The colour of the weathered material were classified based on Rock Colour Chart (2). Petrographic analysis and scanning electron microscopy (SEM) were carried out to analyze the mineralogical and microstructure alterations, respectively due to weathering effect. The changes of physico-mechanical properties at the surrounding of boulder due to weathering were also analyzed including dry density, porosity, point load strength, uniaxial compressive strength and permeability. The dry density and porosity were conducted based on ASTM (3) and Brown (4), respectively. The point load uniaxial compressive strength were carried out according to ISRM (1) while permeability test was undertaken based on Head (5). The tropical granite boulder possessing rindlets with significant different of colours, degree of friability and texture. This differences were classified into four primary zones: corestone (C), inner rindlets (IR), outer rindlets (OR), and saprolites (S) with weathering grade of II, III/IV, IV/V and V, respectively. Due to spheroidal weathering, three to six concentric sheets of rindlets with whitish grey to light brown colour were formed at the surrounding of corestone's boulder. Each sheets of rindlets has 2.0 cm to 3.0 cm thick with total thickness up to 80 cm. The microcracks aperture of IR and OR is ranging from 150 to 200 Âµm and 200 Âµm to 1 mm, respectively. Analysis revealed that the higher the weathering grade, the higher and wider the fracture opening formed in the rindlets up to 2 mm width. Analysis exibited that the increase of weathering grade from Grade II to IV along C to S were significantly reduced the plagioclase, K-feldspar, and biotite with reduction of 74%, 74.2% and 87.5%, respectively. The alteration of minerals and microstructure due to the weathering were significantly reduced the dry density, point load strength, uniaxial compressive strength and permeability with 32%, 99.5%, 98.6% and 84.8%, respectively.The reaction of spheroidal weathering is significantly affecting the physico-mechanical properties of the tropical granite boulders by alteration of its minerals and microstructure characteristics at the surrounding of the boulder.
Le budget de fonctionnement des cabinets ministériels : une zone d’opacité persistante du droitgouvernemental
Authors: Caron Matthieu
Published: February 2020

À cette heure, les données relatives au train de vie des cabinets ministériels ne sont toujours pas publiques. Nous ne savons pratiquement rien des marchés publics passés par ces cabinets ni de leur frais de représentation. Nous n’avons pas davantage d’informations concernant leurs dépenses de restauration, de transport, de logement, de formation ou de communication.Pourtant, la CADA, dans un avis du 23 mai 2013, a bien estimé que les budgets de fonctionnement de ces cabinets étaient des documents administratifs communicables. De surcroît, un jugement du tribunal administratif de Paris en date du 16 décembre 2014 a enjoint le Gouvernement de transmettre ces documents à un citoyen qui en faisait la demande. Enfin, le Gouvernement a manifestement décidé de ne pas répondre aux questions écrites au sujet des cabinets que les députés Christine Pires-Beaune et Régis Juanico lui ont posé en janvier 2019.
Le cabinet du président d’une assembléeparlementaire
Authors: Gicquel Jean-Eric
Published: February 2020

Si les monographies relatives au président d’une assemblée parlementaire sont nombreuses, la structure politico-administrative l’accompagnant, le cabinet, a été très peu abordé. Il s’agira ici de présenter les similitudes organisationnelles avec le cabinet ministériel et ses différences dans le mode de fonctionnement au quotidien.
La nomination des collaborateurs ministériels à l’entrée et à la sortie du cabinet : des processus transparents ?
Authors: Sponchiado Lucie
Published: February 2020

Les décrets du 18 mai 2017 relatif aux cabinets ministériels et du 14 juin 2017 relatif aux collaborateurs du Président de la République et des membres du Gouvernement contribuent à accroitre la transparence dans le domaine des nominations en cabinets ministériels – au moins à l’entrée du ministère – mais signent, dans le même temps, le déclin de l’autonomie organisationnelle du Gouvernement, au profit du président de la République.
L’émergence d’un statut déontologiquedes conseillers ministériels
Authors: Kerléo Jean-François
Published: February 2020

Depuis 1993, les règles déontologiques applicables aux membres des cabinets ministériels se sont multipliées : déclaration de patrimoine et déclaration d’intérêts, procédure informelle de déport, contrôle du pantouflage et des cumuls, relations avec les représentants d’intérêts. Un statut déontologique propre aux cabinets ministériels serait pleinement justifié.
(DARI SEGI STRUKTUR, KONTEKS PENUTURAN, KO-TEKS DAN FUNGSI) DAN PELESTARIANNYA SEBAGAI BAHAN AJAR BAHASA INDONESIA SERTA BAHAN AJAR PELATIHAN EKSTRAKULIKULER DI SMA
Authors: Logita Embang
Published: February 2020

“A Song wedding as Saweran Sundanese tradition  (From Side Sctructure, speech context, co-text,Fungtion)  and Instructional Material Indonesian Language along with Instructional Material As a preservation From Extracurricular Training in School”. Background: young generations are not interested in existence of the saweran in wedding Sundanese  performance art, they thought that it is old tradition. The research problem: how is form of  Saweran art in  Sundanese wedding performance, structure of the text, context,co- text, function and form of preservation in high school? The purpose of the study: to describe art saweran art in Sundanese wedding tradition  performance, presenting definition guide book  Indonesian language and guide book extracurricular training in high school. This research use qualitative descriptive method. Data collection techniques: Triangulasi. Data analysis result: saweran  art Sundanese wedding tradition  performance, shape, semantic and sound formula, co-text ,context, function of songs Saweran art performance and preservation in high school.Research in oral tradition is advetage about saweran  wedding saweran in Sundanese tradition very use for having power Indonesian language from region language”.

“Lagu Saweran dalam Pernikahan Adat Sunda (Dari Segi Struktur, Konteks Penuturan, Ko-teks dan Fungsi) dan Pelestariannya Sebagai Bahan Ajar Bahasa Indonesia Serta Bahan Ajar Pelatihan Ekstrakurikuler. Latar belakang: keberadaan pertunjukan saweran dalam pernikahan adat Sunda  yang hampir  tidak diminati oleh generasi muda yang beranggapan merupakan kesenian yang bertradisi lama. Masalah penelitian: Bagaimana bentuk pertunjukan saweran dalam pernikahan adat Sunda, struktur teks, ko-teks, konteks, fungsi dan bentuk pelestarian di SMA? Tujuan dari penelitian: mendeskripsikan  pertunjukan saweran dalam pernikahan adat Sunda, menyajikan ancangan buku ajar Bahasa Indonesia dan buku panduan pelatihan ekstrakurikuler di SMA. Penelitian ini menggunakan metode deskriptif kualitatif. Teknik pengumpulan data: Triangulasi. Hasil analisis data: mengenai pertunjukan saweran dalam pernikahan adat Sunda, bentuk, semantik dan formula bunyi, ko-teks dan konteks, fungsi dari lagu-lagu pertunjukan pertunjukan saweran dalam pernikahan adat Sunda, dan pelestariannya di SMA Penelitian dalam tradisi lisan sangat bermanfaat untuk memperkaya  bahasa Indonesia dari bahasa daerah”.
MARKET OF RAPE PLANT: CONDITION AND PROSPECTS FOR KAZAKHSTAN
Authors: G. Sh. Kаliakparova  , Y. E. Gridneva  , K. S. Alpysbayev  , T. Sevindik
Published: February 2020

The article shows current situation and dynamics of development of global and Kazakhstani rapeseed market over the past several years. Development of the rapeseed market is observed not only in Kazakhstan, the sown area under oilseeds is expanding everywhere in many foreign countries. Use of rapeseed is observed in various sectors of the economy: in agriculture, in the production of animal feed, in the food industry, rapeseed oil is used, rapeseed is used in cosmetology, etc.
Authors revealed importance of rapeseed for the further development of certain sectors of the economy. The article analyzes production and consumption of rapeseed, shows the dynamics of changes in the area under rape. In order to justify the material presented, statistical data were used for a number of years, starting from 2013 to 2019.
Authors of the article evaluated rapeseed production by the main world producers. The consumption of rapeseed by country is considered. Dynamics of changes in the area under rape in Kazakhstan is examined and studied. The main reasons affecting the development of the domestic rapeseed market are identified. The practical relevance of solving these problems, the poor study of certain issues of the methodology and practice of managing the competitiveness of the rapeseed market in Kazakhstan indicates the relevance of the study. The rapeseed market has favorable conditions for the development of this crop.
Comunicação social e saúde: Conscientização e incentivo a imunização
Authors: Santos Gustavo Gonçalves dos , Santos Vitória Gonçalves dos
Published: February 2020

Objetivo: Descrever sobre o poder Comunicação Social na Enfermagem em relação ao incentivo e conscientização em relação às campanhas de vacinação. Método: Trata-se de uma revisão bibliográfica, realizada no período de Fevereiro à Julho de 2019. Foram utilizados 10 estudos como referencial teórico relativo à Saúde e Comunicação Social com ênfase na Publicidade e Propaganda por meio de fontes como publicações do Ministério da Saúde, Organização Mundial da Saúde e artigos de periódicos científicos publicados nos últimos dez anos, disponibilizados na Biblioteca Virtual: SciELO, LILACS, BDEFN e Google Acadêmico, utilizando os descritores: Calendário Vacinal, Imunização, Comunicação Social. Resultados: A Comunicação Social em saúde oferece condições significantes e relevantes para as boas práticas de promoção à saúde, favorecendo o estímulo do autocuidado e o cuidado dos usuários do serviço de saúde. Conclusões: Mobilizar profissionais da saúde e os usuários dos serviços de saúde no que se diz respeito à conscientização e incentivo da imunização. Descritores: calendário vacinal, imunização, comunicação social.
ЕКСПЕРИМЕНТАЛЬНІ МЕТОДИ ОЦІНЮВАННЯ ЕФЕКТИВНОСТІ ЗАСТОСУВАННЯ ПЕРЕНОСНИХ ЗАСОБІВ ДИМО- ТА ТЕПЛОВИДАЛЕННЯ
Authors: Semichaevskiy S , Prisyazhnuk V , Yakimenko M , Osadchuk M , Kurtov O , Milutin O
Published: February 2020

Наведено результати експериментальних досліджень з визначення коефіцієнту ефективного зменшення задимленості і коефіцієнту ефективного зниження температури під час реалізації трьох варіантів нормалізації газоповітряного середовища у випробувальному боксі, а саме під час створення задимленого та високотемпературного середовища та подальшого самостійного зменшення задимленості і зниження температури, під час димо та тепловидалення шляхом нагнітання повітря та шляхом одночасного подавання повітря та розпиленого струменя води до випробувального боксу за допомогою переносного засобу димо- та тепловидалення
Prevalence of Disease and Antibiotic Sensitivity Profile of Hospital Associated Pathogens: A study on a local diagnostic Centre in Dhaka city
Authors: Ahmed Sharmin , Islam Riajul , Ahsan Sunjukta
Published: February 2020

Different types of diseases inflict the inhabitants of Dhaka city from time to time. The focus of this study was to investigate disease prevalence, etiology and antibiotic sensitivity profiles reported at a local diagnostic service in Dhaka, Bangladesh. Pathogens were transported from a renowned local diagnostic centre in Dhaka city in Trypticase Soy broth (TSB) to the laboratory. Antibiogram was performed by Kirby Bauer disc diffusion assay. A total of 110 samples (20% blood (n = 22), 60.9% urine (n = 67), 13.64% pus (n =15), 3.64% sputum (n = 4) and 1.82% wound swab samples (n = 2) were collected for further investigation. Of the patients, 30% were male and 70% were female. In case of blood samples from diarrheal patients, Salmonella enterica serovar Typhi (72.7%) and S. enterica serovars Paratyphi (27.2%) were predominant. Both serovars were sensitive to Cefixime, Ceftriaxone and Gentamicin and resistant to Nalidixic acid. E. coli (91%) was the predominant pathogen in Urinary Tract Infection (UTI) patients followed by Klebsiella spp. (8.9%). E. coli exhibited resistance to Cephalosporins and Ciprofloxacin whereas Klebsiella spp. were, however, sensitive to these antibiotics. Both species showed resistance against Amoxicillin and sensitivity to Imipenem, Merpenem and Colistin. In pus samples, S. aureus (46.7%) prevailed followed by Klebsiella spp. (26.7%) and E. coli (26.7%) spp. All S. aureus isolates were sensitive to Fusidic acid, Vancomycin, Linezolid and Piperacillin and 50% were sensitive to Cephalosporins and Ciprofloxacin and resistant to Amoxycillin and Azithromycin. E. coli and Klebsiella spp. from pus samples could be inhibited by Carbapenem. As with UTI isolates, E. coli from pus were resistant to Cephalosporins, Ciprofloxacin and Amoxicillin whereas 66% Klebsiella spp. were sensitive to the first two. A total of 66% of E. coli and Klebsiella spp. showed sensitivity to Gentamicin and Amikacin. It was observed that there was a similarity in the antibiotic sensitivity pattern of the same bacterial spp. isolated from different disease cases. As a general rule, it was observed that Imipenem is a good treatment option for treating E. coli and Klebsiella spp., Cephalosporins for Salmonella while a number of treatment options existed for S. aureus infections.

Bangladesh J Microbiol, Volume 36 Number 2 December 2019, pp 99-104
Somewhere between here and there: Negotiating Researcher Visibility in a Digital Ethnography of the Influencer Industry
Authors: Abidin Crystal
Published: February 2020

Despite our preparation for fieldwork, a majority of what ethnographers actually do in the field is based on ‘gut-feeling’, ‘sensing’, and ‘whim’. This paper is a piece of reflexive ethnography detailing a series of minor but important methodological decisions pertaining to researcher visibility throughout fieldwork in a digital community of social media Influencers. It details one anthropologist’s private negotiations during the foray into the Influencer industry by situating the self along various spectrums of conspicuousness. These confessional anecdotes of ‘behind the scenes’ labour can be taken as suggestions on how to negotiate one’s positionalities during ethnographic encounters between and betwixt physical and digital fieldsites. I detail these through six experiences from the field – as the esteemed guest, the exotic inbetweener, the willing apprentice, the trophy acquaintance, the concealed consultant, and the passing confidante – in which I negotiate being ‘seen’, being on ‘show’, and ‘seeing’ from somewhere between here and there.
Актуальний аспект кримінально-правової охорони земельних відносин в Україні
Authors: Дудоров О. О. , Мовчан Р. О.
Published: February 2020

Рецензія на кн.: Крайник Г. С. Кримінальна відповідальність за забруднення або псування земель в Україні: монографія. Харків: Друкарня Мадрид, 2019. 204 с.
Feed-Forward Controlling of Servo-Hydraulic Actuators Utilizing a Least-Squares Support-Vector Machine
Authors: Sharghi Amir Hossein , Karami Mohammadi Reza , Farrokh Mojtaba , Zolfagharysaravi Sina
Published: February 2020

Feed-forward control of hysteretic systems is a challenging task due to the hysteresis nonlinearity. Hysteresis models are utilized not only for identification, but also for hysteresis control. The feed-forward control, which is not an error-based (feedback-based) algorithm, plays a significant role in hysteresis control problems. Instead, it works based on knowledge about the process in the form of a mathematical model of the process. In feed-forward control problems, it is important to identify the inverse relationship of the output and input of the system, i.e., determining the mapping of the output and input of the system plays a key role in feed-forward controlling. This paper presents a new feed-forward controller model to control an actuator in a laboratory to tackle the restrictions of feedback control systems. For this purpose, first, a numerical model of a Proportional-Integral-Derivative (PID)-controlled actuator was created, and sets of numerical data of inputs and outputs of the plant were generated. Then, a least-squares support-vector machine (LS-SVM) hysteresis model was trained inversely on the generated data sets of the numerical modeling. Afterwards, to examine the efficacy of the proposed method for real-world hydraulic actuators in the presence of experimental errors and noise, sets of experimental data were obtained from physical modeling at KNTU’s Structural and Earthquake Engineering Laboratory (KSEEL). The results indicate the high performance of the proposed model.
Cocoa Flavonoids Reduce Inflammation and Oxidative Stress in a Myocardial Ischemia-Reperfusion Experimental Model
Authors: Ahmed Sajeela , Ahmed Naseer , Rungatscher Alessio , Linardi Daniele , Kulsoom Bibi , Innamorati Giulio , Meo Sultan Ayoub , Gebrie Mebratu Alebachew , Mani Romel , Merigo Flavia , Guzzo Flavia , Faggian Giuseppe
Published: February 2020

Consumption of flavonoid-rich nutraceuticals has been associated with a reduction in coronary events. The present study analyzed the effects of cocoa flavonols on myocardial injury following acute coronary ischemia-reperfusion (I/R). A commercially available cocoa extract was identified by chromatographic mass spectrometry. Nineteen different phenolic compounds were identified and 250 mg of flavan-3-ols (procyanidin) were isolated in 1 g of extract. Oral administration of cocoa extract in incremental doses from 5 mg/kg up to 25 mg/kg daily for 15 days in Sprague Dawley rats (n = 30) produced a corresponding increase of blood serum polyphenols and become constant after 15 mg/kg. Consequently, the selected dose (15 mg/kg) of cocoa extract was administered orally daily for 15 days in a treated group (n = 10) and an untreated group served as control (n = 10). Both groups underwent surgical occlusion of the left anterior descending coronary artery and reperfusion. Cocoa extract treatment significantly reversed membrane peroxidation, nitro-oxidative stress, and decreased inflammatory markers (IL-6 and NF-kB) caused by myocardial I/R injury and enhanced activation of both p-Akt and p-Erk1/2. Daily administration of cocoa extract in rats is protective against myocardial I/R injury and attenuate nitro-oxidative stress, inflammation, and mitigates myocardial apoptosis.
Multidirectional Pharma-Toxicological Study on Harpagophytum procumbens DC. ex Meisn.: An IBD-Focused Investigation
Authors: Recinella Lucia , Chiavaroli Annalisa , Ronci Maurizio , Menghini Luigi , Brunetti Luigi , Leone Sheila , Tirillini Bruno , Angelini Paola , Covino Stefano , Venanzoni Roberto , Zengin Gokhan , Simone Simonetta Di , Ciferri Maria Chiara , Giacomo Viviana di , Cataldi Amelia , Rapino Monica , Valerio Valentina Di , Orlando Giustino , Ferrante Claudio
Published: February 2020

In the present study, we investigated the water extract of Harpagophytum procumbens DC. ex Meisn. in an experimental model of inflammatory bowel diseases (IBDs). Additionally, a microbiological investigation was carried out to discriminate the efficacy against bacterial and fungal strains involved in IBDs. Finally, an untargeted proteomic analysis was conducted on more than one hundred colon proteins involved in tissue morphology and metabolism. The extract was effective in blunting the production of oxidative stress and inflammation, including serotonin, prostaglandins, cytokines, and transcription factors. Additionally, the extract inhibited the growth of Candida albicans and C. tropicalis. The extract was also able to exert a pro-homeostatic effect on the levels of a wide plethora of colon proteins, thus corroborating a protective effect. Conversely, the supraphysiological downregulation of cytoskeletal-related proteins involved in tissue morphology and antimicrobial barrier function suggests a warning in the use of food supplements containing H. procumbens extracts.
A Hybrid Degradation Modeling and Prognostic Method for the Multi-Modal System
Authors: Peng Jun , Wang Shengnan , Gao Dianzhu , Zhang Xiaoyong , Chen Bin , Cheng Yijun , Yang Yingze , Yu Wentao , Huang Zhiwu
Published: February 2020

Engineering systems typically go through complicated degradation processes, partially due to their multiple operating modes. Therefore, how to accurately estimate their remaining useful life is a critical issue. To address this challenge, a hybrid degradation modeling and prognostic method for the multi-modal system is proposed. Firstly, the cumulative dynamic differential health indicator is constructed for the multi-modal switching system using a multi-objective optimization approach. The long-term cumulative degradation assessment model is constructed based on the gated recurrent unit. Then, considering that the damage in the latest stage has a significant impact on the remaining useful life, the time window is used to extract local features of the sequence, including energy features and statistical features. The latest stage degradation is predicted based on the light gradient boosting machine. Finally, model averaging is used to integrate the two predicted results, which is expected to improve the prognostic robustness. The proposed model is evaluated with synthetic analysis and NASA turbofan aero-engine datasets. Extensive experimental results demonstrate the proposed method provides a better characterization of the degradation status of the system and provides a higher estimation accuracy than existing methods.
Low Temperature District Heating: An Expert Opinion Survey
Authors: Guzzini Alessandro , Pellegrini Marco , Pelliconi Edoardo , Saccani Cesare
Published: February 2020

Among the available solutions for building heating and cooling, district heating (DH) and district cooling (DC) systems are considered some of the best options since they can ensure a better control of pollutant emissions and greater efficiency than individual systems. Nevertheless, improvements are needed to increase their sustainability and reliability. The so-called “low temperature district heating” (LTDH) concept has been introduced in recent years in an attempt (i) to reduce the distribution heat losses through a temperature decrease in the DH network, (ii) to favor the integration with renewable energy sources, and (iii) to create the conditions required for the development of future smart energy systems. However, many concerns have been raised about its implementation in both existing and new systems. For this reason, this paper aims to identify the stakeholders’ ranking of the barriers against LTDH system development and implementation over the next few years. Aiming to this, a questionnaire was designed, including an analysis of current gaps and strengths, and then submitted to more than 50 Italian and international experts in the field of DH. An in-depth analysis of the received answers was performed, focusing in particular on the Italian experts’ answers. Comments and suggestions on how to promote the transition to the new LTDH approach are reported.
Composite Sinusoidal Waveform Generated by Direct Digital Synthesis for Healthy Charging of Lithium-Ion Batteries
Authors: Chen Po-Tuan , Zeng Fu-Yen , Zhang Xuan-Hao , Chung Ren-Jei , Yang Cheng-Jung , Huang K. David
Published: February 2020

To address the defects in lithium-ion battery lifespan, this paper proposes a composite waveform generation strategy that offers capacity-recovering effect. Based on digital architecture, this study exploits direct digital synthesis (DDS) to generate data, which are then processed in an analog-to-digital converter to produce a predefined voltage waveform signal. In the process, an arbitrary waveform is converted to digital voltage waveform signal through pulse width modulation (PWM) technology, thus realizing waveform generation through DDS. Subsequently, analog-to-digital conversion is accomplished by going through a buck circuit, resulting in a composite sinusoidal waveform that is used to charge the battery with a recovering effect. This paper comprises an introduction of effective waveforms for capacity recovering, methods of generating composite sinusoidal waveforms, and an example of the application of composite sinusoidal waveform generation. The waveform produced by the circuit may recover the capacity of an aged 18650 lithium-ion battery by about 8%.
Solvent-Dictated Sodium Sulfur Redox Reactions: Investigation of Carbonate and Ether Electrolytes
Authors: Zhang Huang , Diemant Thomas , Qin Bingsheng , Li Huihua , Behm R. Jürgen , Passerini Stefano
Published: February 2020

Sulfur-based cathode chemistries are essential for the development of high energy density alkali-ion batteries. Here, we elucidate the redox kinetics of sulfur confined on carbon nanotubes, comparing its performance in ether-based and carbonate-based electrolytes at room temperature. The solvent is found to play a key role for the electrochemical reactivity of the sulfur cathode in sodium–sulfur (Na–S) batteries. Ether-based electrolytes contribute to a more complete reduction of sulfur and enable a higher electrochemical reversibility. On the other hand, an irreversible solution-phase reaction is observed in carbonate solvents. This study clearly reveals the solvent-dependent Na–S reaction pathways in room temperature Na–S batteries and provides an insight into realizing their high energy potential, via electrolyte formulation design.
A Computer Vision Line-Tracking Algorithm for Automatic UAV Photovoltaic Plants Monitoring Applications
Authors: Roggi Gabriele , Niccolai Alessandro , Grimaccia Francesco , Lovera Marco
Published: February 2020

In this paper, the authors propose an UAV-based automatic inspection method for photovoltaic plants analyzing and testing a vision-based guidance method developed to this purpose. The maintenance of PV plants represents a key aspect for the profitability in energy production and autonomous inspection of such systems is a promising technology especially for large utility-scale plants where manned techniques have significant limitations in terms of time, cost and performance. In this light, an ad hoc flight control solution is investigated to exploit available UAV sensor data to enhance flight monitoring capability and correct GNSS position errors with respect to final target needs. The proposed algorithm has been tested in a simulated environment with a software-in-the loop (SITL) approach to show its effectiveness and final comparison with state of the art solutions.
The Development Strategies and Technology Roadmap of Bioenergy for a Typical Region: A Case Study in the Beijing-Tianjin-Hebei Region in China
Authors: Zhang Xin , Li Yun-Ze , Wang Ao-Bing , Gao Li-Jun , Xu Hui-Juan , Ning Xian-Wen
Published: February 2020

The Beijing-Tianjin-Hebei region has abundant biomass resources, which are difficult to collect and thus are underutilized. However, the potential estimation of biomass energy can result in a comprehensive understanding of bioenergy resources in order to establish a technology roadmap for the region’s bioenergy development. Therefore, it is essential to estimate the potential of Beijing-Tianjin-Hebei biomass resources and bioenergy utilization. In this paper, the amount of main biomass resources for possible energy use and bioenergy utilization are calculated based on a statistical data estimation method for crop residues; human, poultry, and livestock manure; and municipal solid wastes. On the basis of biomass resources and bioenergy utilization potential, the technology roadmap is established. The results show that the amount for available biomass energy use is unevenly distributed in the Beijing-Tianjin-Hebei region, and the largest amount of resources is crop residues (36.52 million tons or 18.26 million tons coal equivalent). The biogas from human, poultry, and livestock manure and densified solids from crop residue technology roadmap is suitable for the Beijing-Tianjin-Hebei region.
A Hybrid Model for Lift Response to Dynamic Actuation on a Stalled Airfoil
Authors: An Xuanhong , Williams David R. , Hemati Maziar S.
Published: February 2020

The current research focuses on modeling the lift response due to dynamic (time-varying) “burst-type” actuation on a stalled airfoil. Here, the “burst-type” actuation refers to the synthetic jet (generated from the actuator) that is used for flow separation mitigation. Dynamic “burst-type” actuation exhibits two different characteristic dynamic behaviors within the system; namely, the high-frequency and low-frequency components. These characteristics introduce modeling challenges. In this paper, we propose a hybrid model composed of two individual sub-models, one for each of the two frequencies. The lift response due to high-frequency burst actuation is captured using a convolution model. The low-frequency component due to nonlinear burst-burst interactions is captured using a Wiener model, consisting of linear time-invariant dynamics and a static output nonlinearity. The hybrid model is validated using data from wind tunnel experiments.
Control the Voltage Instabilities of Distribution Lines using Capacitive Reactive Power
Authors: Rajput Shailendra , Amiel Ido , Sitbon Moshe , Aharon Ilan , Averbukh Moshe
Published: February 2020

The voltage instabilities in the distribution lines are primarily related to the integration of photovoltaic power plants with the local grids. Conventional tap-changers cannot compensate for the rapid disparities between generated and consumed power because of sluggish dynamic response. This article presents an effective method and control algorithm to improve the voltage instabilities of distribution lines. Analytical calculation confirms that the application of capacitive reactive power on load is beneficial to keep the voltage at the permissible level. Importantly, the severe concern about the current increment with voltage enhancement is also addressed. The dynamic behavior during capacitance switching is studied using simulation experiments. It is suggested that capacitance is connected to the load for the only time of voltage drop until the transformation ratio changes to the desired level. This article provides an explanation and solution for voltage deviations of electricity distribution lines in steady-state and dynamic modes.
The Use of AHP to Prioritize Five Waste Processing Plants Locations in Krakow
Authors: Siejka Monika
Published: February 2020

The purpose of the paper is to use the analytic hierarchy process (AHP) to determine the prioritization of areas designated for infrastructure investments. The research was carried out using an example of a municipal solid waste incineration plant in Kraków. Based on research tests conducted on actual field data, this paper proves that spatial information systems can be a useful source of information in decision-making processes related to the assessment of the location of an investment project with a function so important for the natural environment and maintaining the principle of sustainable development. Owing to the development of technologies such as remote sensing and GIS, the obtained data are of high quality, and the possibility for processing and making them available in real time makes them up to date. The research methodology for selecting areas for a well-defined purpose includes five separate stages: Defining the parameters, acquiring data from spatial information systems, data standardization, criteria weighting by the analytic hierarchy process (AHP), calculation of the coefficient of area suitability for the location of a particular facility, and its graphic representation on a map. The final result is the ranking of areas in terms of suitability for the implementation of an infrastructural project i.e., the construction of a municipal waste incineration plant.
Topical Drug Delivery Systems Based on Bacterial Nanocellulose: Accelerated Stability Testing
Authors: Silva Nuno H. C. S. , Mota Joana P. , Santos de Almeida Tânia , Carvalho João P. F. , Silvestre Armando J. D. , Vilela Carla , Rosado Catarina , Freire Carmen S. R.
Published: February 2020

Bacterial nanocellulose (BNC) membranes have enormous potential as systems for topical drug delivery due to their intrinsic biocompatibility and three-dimensional nanoporous structure, which can house all kinds of active pharmaceutical ingredients (APIs). Thus, the present study investigated the long-term storage stability of BNC membranes loaded with both hydrophilic and lipophilic APIs, namely, caffeine, lidocaine, ibuprofen and diclofenac. The storage stability was evaluated under accelerated testing conditions at different temperatures and relative humidity (RH), i.e., 75% RH/40 °C, 60% RH/25 °C and 0% RH/40 °C. All systems were quite stable under these storage conditions with no significant structural and morphological changes or variations in the drug release profile. The only difference observed was in the moisture-uptake, which increased with RH due to the hydrophilic nature of BNC. Furthermore, the caffeine-loaded BNC membrane was selected for in vivo cutaneous compatibility studies, where patches were applied in the volar forearm of twenty volunteers for 24 h. The cutaneous responses were assessed by non-invasive measurements and the tests revealed good compatibility for caffeine-loaded BNC membranes. These results highlight the good storage stability of the API-loaded BNC membranes and their cutaneous compatibility, which confirms the real potential of these dermal delivery systems.
Interleukin-17A and Keratinocytes in Psoriasis
Authors: Furue Masutaka , Furue Kazuhisa , Tsuji Gaku , Nakahara Takeshi
Published: February 2020

The excellent clinical efficacy of anti-interleukin 17A (IL-17A) biologics on psoriasis indicates a crucial pathogenic role of IL-17A in this autoinflammatory skin disease. IL-17A accelerates the proliferation of epidermal keratinocytes. Keratinocytes produce a myriad of antimicrobial peptides and chemokines, such as CXCL1, CXCL2, CXCL8, and CCL20. Antimicrobial peptides enhance skin inflammation. IL-17A is capable of upregulating the production of these chemokines and antimicrobial peptides in keratinocytes. CXCL1, CXCL2, and CXCL8 recruit neutrophils and CCL20 chemoattracts IL-17A-producing CCR6+ immune cells, which further contributes to forming an IL-17A-rich milieu. This feed-forward pathogenic process results in characteristic histopathological features, such as epidermal hyperproliferation, intraepidermal neutrophilic microabscess, and dermal CCR6+ cell infiltration. In this review, we focus on IL-17A and keratinocyte interaction regarding psoriasis pathogenesis.
Genetic Dissection of Germinability under Low Temperature by Building a Resequencing Linkage Map in japonica Rice
Authors: Jiang Shukun , Yang Chao , Xu Quan , Wang Lizhi , Yang Xianli , Song Xianwei , Wang Jiayu , Zhang Xijuan , Li Bo , Li Hongyu , Li Zhugang , Li Wenhua
Published: February 2020

Among all cereals, rice is highly sensitive to cold stress, especially at the germination stage, which adversely impacts its germination ability, seed vigor, crop stand establishment, and, ultimately, grain yield. The dissection of novel quantitative trait loci (QTLs) or genes conferring a low-temperature germination (LTG) ability can significantly accelerate cold-tolerant rice breeding to ensure the wide application of rice cultivation through the direct seeding method. In this study, we identified 11 QTLs for LTG using 144 recombinant inbred lines (RILs) derived from a cross between a cold-tolerant variety, Lijiangxintuanheigu (LTH), and a cold-sensitive variety, Shennong265 (SN265). By resequencing two parents and RIL lines, a high-density bin map, including 2,828 bin markers, was constructed using 123,859 single-nucleotide polymorphisms (SNPs) between two parents. The total genetic distance corresponding to all 12 chromosome linkage maps was 2,840.12 cm. Adjacent markers were marked by an average genetic distance of 1.01 cm, corresponding to a 128.80 kb physical distance. Eight and three QTL alleles had positive effects inherited from LTH and SN265, respectively. Moreover, a pleiotropic QTL was identified for a higher number of erected panicles and a higher grain number on Chr-9 near the previously cloned DEP1 gene. Among the LTG QTLs, qLTG3 and qLTG7b were also located at relatively small genetic intervals that define two known LTG genes, qLTG3-1 and OsSAP16. Sequencing comparisons between the two parents demonstrated that LTH possesses qLTG3-1 and OsSAP16 genes, and SN-265 owns the DEP1 gene. These comparison results strengthen the accuracy and mapping resolution power of the bin map and population. Later, fine mapping was done for qLTG6 at 45.80 kb through four key homozygous recombinant lines derived from a population with 1569 segregating plants. Finally, LOC_Os06g01320 was identified as the most possible candidate gene for qLTG6, which contains a missense mutation and a 32-bp deletion/insertion at the promoter between the two parents. LTH was observed to have lower expression levels in comparison with SN265 and was commonly detected at low temperatures. In conclusion, these results strengthen our understanding of the impacts of cold temperature stress on seed vigor and germination abilities and help improve the mechanisms of rice breeding programs to breed cold-tolerant varieties.
Aquaporin 1, 3, and 5 Patterns in Salivary Gland Mucoepidermoid Carcinoma: Expression in Surgical Specimens and an In Vitro Pilot Study
Authors: Stamboni Mérin Barbara , Gomes Ágatha Nagli de Mello , Souza Milena Monteiro de , Oliveira Katia Klug , Arruda Claudia Fabiana Joca , de Paula Fernanda , Bettim Barbara Beltrame , Marques Márcia Martins , Kowalski Luiz Paulo , Pinto Clóvis Antônio Lopes , Arana-Chavez Victor Elias , Lourenço Silvia Vanessa , Coutinho-Camillo Cláudia Malheiros
Published: February 2020

Salivary gland aquaporins (AQPs) are essential for the control of saliva production and maintenance of glandular structure. However, little is known of their role in salivary gland neoplasia. Salivary gland tumors comprise a heterogeneous group of lesions, featuring variable histological characteristics and diverse clinical behaviors. Mucoepidermoid carcinoma (MEC) is the most common salivary gland malignancy. The aim of this study was to evaluate the expression of AQP1, AQP3, and AQP5 in 24 MEC samples by immunohistochemistry. AQP1 expression was observed in vascular endothelium throughout the tumor stroma. AQP3 was expressed in epidermoid and mucosal cells and AQP5 was expressed in mucosal cells of MEC. These proteins were expressed in the human MEC cell line UH-HMC-3A. Cellular ultrastructural aspects were analyzed by electron microscopy to certificate the tumor cell phenotype. In summary, our results show that, despite the fact that these molecules are important for salivary gland physiology, they may not play a distinct role in tumorigenesis in MEC. Additionally, the in vitro model may offer new possibilities to further investigate mechanisms of these molecules in tumor biology and their real significance in prognosis and possible target therapies.