bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH PERSON-JOB FIT TERHADAP KINERJA KARYAWAN DENGAN MEDIASI KOMITMEN ORGANISASI DAN PERILAKU KEWARGAAN ORGANISASI PADA KARYAWANGENERASI Z PERUSAHAAN DI JAWA TIMUR
Authors: Viryananta Davala Ilhan Setya , Prawitowati Tjahjani
Published: September 2024

Kinerja karyawan yang baik akan membawa dampak yang positif bagi perusahaan yang ditempatinya. Kinerja karyawan merupakan hasil kuantitas dan kualitas yang dicapai oleh seorang individu dalam melaksanakan tugasnya sesuai dengan tanggung jawab yang diberikan. Kinerja karyawan mengacu pada nilai, kualitas atau kuantitas pekerjaan yang disumbangkan oleh seorang karyawan, yaitu produktivitas seorang karyawan. Tujuan penelitian ini adalah untuk mengetahui pengaruh person-job fit, komitmen organisasi, dan perilaku kewargaan organisasi terhadap kinerja karyawan generasi Z perusahaan di Jawa Timur. Metode penelitian menggunakan metode kuantitatif. Teknik pengambilan data menggunakan survey. Instrumen yang digunakan berupa kuesioner. Penelitian ini dilakukan di karyawan generasi Z perusahaan di Jawa Timur dengan menggunakan metode kuantitatif. Penelitian ini melibatkan 127 karyawan dan data dianalisis dengan menggunakan SmartPLS. Peneliti menggunakan Partial Least Square Structural Equation Modelling (PLS-SEM). Hasil penelitian menunjukan tingkat person-job fit, komitmen organisasi, dan perilaku kinerja karyawan berpengaruh positif terhadap kinerja karyawan. Semakin tinggi tingkat person-job fit, semakin baik kinerja karyawan, semakin baik komitmen organisasi, semakin baik kinerja karyawan, semakin baik perilaku kewargaan organisasi, semakin baik juga kinerja karyawan.  Sebagai saran dan hasil peneliti adalah perusahaan dapat mengimplementasikan program rencana-rencana pengembang person-job fit, komitmen organisasi, dan perilaku kewargaan organisasi dengan baik untuk menungkatkan kinerja karyawan.
BOARD DIVERSITY, CORPORATE SOCIAL RESPONSIBILITY, AND FINANCIAL PERFORMANCE: AN EMPIRICAL STUDY ON CONSUMER NON-CYCLICAL FIRMS
Authors: Ainun Nizmah Kemala , Nurul Innayah Maulida , Purwidianti Wida , Bagis Fatmah
Published: September 2024

This study aimed to examine the effect of board diversity on financial performance of consumer non-cyclicals companies listed on the Indonesia Stock Exchange. This study also examined the mediating effect of Corporate Social Responsibility on the relationship between board diversity and financial performance which was limited in previous studies. The sampling technique used was purposive sampling which obtained 136 observations. The results showed that female directors, foreign directors, and directors with economic education have a negative effect on financial performance. Female directors and foreign directors have a positive effect on CSR, while directors with economic education have a negative effect on CSR. CSR has a positive effect on financial performance. However, based on the sobel test results, CSR is not able to mediate the relationship between board diversity on financial performance. This research has contributed for consumer non-cyclicals companies to consider the role of board diversity, because this research found that they are able to increase CSR disclosure and firm performance.
NETFLIX AND TELKOMSEL BUNDLING: DOES SYMBOLIC VALUE MATTER IN CO-BRANDING
Authors: Gede Pamungkas Ardianta , Suparna Gede , Yudi Setiawan Putu , Gusti Agung Ketut Gede Suasana I
Published: September 2024

The Subscription Video on Demand market in Indonesia has seen substantial growth, but Netflix's market share dropped by 10% in Q2 2022, losing about 2 million subscribers. To boost customer purchase intention, Netflix partnered with Telkomsel, a leading telecommunication provider, to offer a bundled package. This study explores the mediating role of brand attitude between symbolic value, perceived benefits, and customer purchase intention for the Netflix-Telkomsel bundle. Using an associative quantitative approach and a sample of 100 respondents, data were analyzed with Partial Least Squares (PLS). The results reveal that symbolic value insignificantly influences purchase intention or brand attitude. However, perceived benefits positively and significantly impact both purchase intention and brand attitude. Brand attitude also positively influences purchase intention and mediates the effect of perceived benefits on purchase intention, but not that of symbolic value. Prospective customers prioritize perceived benefits over symbolic value when deciding to purchase the Netflix-Telkomsel bundle.
THE EFFECT OF PRODUCT QUALITY AND PRICE ON LOYALTY OF TELKOMSEL PREPAID CARD USERS WITH CUSTOMER SATISFACTION AS A MEDIATING VARIABLE
Authors: Puspita Dela , Sarmigi Elex , Azhar Azhar
Published: September 2024

This study aims to examine the Influence of Product Quality and Price on the Loyalty of Telkomsel Prepaid Card Users with Customer Satisfaction as a Mediating Variable. This research employs a quantitative method with a sample size of 101 respondents who are Telkomsel card users in Sungai Penuh City, calculated based on the Lemeshow formula. Data was collected using a questionnaire distributed online via Google Forms and analyzed using Partial Least Squares Structural Equation Modeling (PLS-SEM). The results of the study show that price has a positive effect on customer satisfaction. Price does not have an effect on consumer loyalty. Customer satisfaction has a positive effect on consumer loyalty. Product quality has a positive effect on customer satisfaction. Product quality does not have an effect on consumer loyalty. The study also proves that customer satisfaction does not mediate the relationship between price and consumer loyalty, but customer satisfaction does mediate the relationship between product quality and consumer loyalty.
RANCANG BANGUN SISTEM INFORMASI QURANU (AL-QUR’AN TUNARUNGU) SEBAGAI UPAYA PENINGKATAN AKSESIBILITAS BELAJAR BACAAN AL-QUR’AN BERBASIS WEBSITE
Authors: Suhada Destia , Fadhilah A. Nur , Rohmawati S. Antya , Afwani Royana , Dwiyansaputra Ramaditia
Published: September 2024

Al-Qur'an adalah kitab suci umat Islam yang menjadi pedoman hidup bagi setiap muslim, termasuk penyandang disabilitas tunarungu. Di Indonesia, khususnya Nusa Tenggara Barat, terdapat 3.921 penyandang disabilitas tunarungu berusia 5 tahun ke atas. Jumlah yang cukup tinggi ini memerlukan peningkatan aksesibilitas pendidikan agama, terutama cara membaca Al-Qur'an. Sayangnya, kurangnya juru Al-Qur'an isyarat dan pendidikan intensif dari lingkungan sekitar sering menghambat proses pembelajaran. Untuk mengatasi hal ini, dikembangkanlah website Quranu, sebuah platform yang memfasilitasi belajar Al-Qur'an Isyarat di mana saja dan kapan saja. Pengembangan Quranu menggunakan metode waterfall, yang memastikan sistematik dan keteraturan dalam prosesnya. Quranu berhasil dikembangkan dengan lima fitur utama, yaitu pembelajaran Al-Qur'an, Kisah Nabi, dan latihan soal, yang telah diterapkan kepada 83 pengguna. Pengguna ini terdiri dari penyandang disabilitas tunarungu, orang tua, dan pengajar Al-Qur'an isyarat di Nusa Tenggara Barat. Berdasarkan survei kepuasan pengguna, lebih dari 96% responden memberikan penilaian baik hingga sangat baik pada berbagai aspek yang diukur. Hasil ini menunjukkan bahwa Quranu telah dirancang dan dikembangkan dengan sukses, sesuai kebutuhan pengguna.
PELATIHAN ROBOTIK DAN PEMROGRAMAN BLOK UNTUK MENINGKATKAN MINAT BELAJAR STEM SEJAK DINI
Authors: Arimbawa I Wayan Agus , Wijayanto Heri , Jatmika Andy Hidayat , Huwae Raphael Bianco , Rizky Dimas Maulana , Rizky Maulana , Witarsana I Nengah Dwi Putra , Ramadhani Rizky Insania , Zahrani Nurul Qalbi
Published: September 2024

Program pengabdian ini bertujuan untuk meningkatkan minat belajar siswa sekolah dasar dalam bidang STEM (Science, Technology, Engineering, and Mathematics) melalui pelatihan robotik dan pemrograman blok. Mengingat rendahnya pencapaian siswa Indonesia dalam studi internasional seperti TIMSS dan PISA, pendekatan ini diharapkan dapat memberikan solusi inovatif yang mampu memotivasi siswa sejak dini. Metode pengabdian meliputi pelatihan praktis dalam dua modul utama: pengenalan robotik dan pemrograman menggunakan Scratch. Pelatihan ini melibatkan 22 siswa dari SDN Model Mataram, yang dilaksanakan dari 31 Juli 2024 hingga 29 Agustus 2024, dengan frekuensi pertemuan dua kali seminggu selama 60 menit setiap sesi, di bawah bimbingan tim mentor. Hasil kegiatan menunjukkan bahwa 59,1% peserta sangat tertarik dan 31,8% tertarik pada pembelajaran robotik, sementara untuk pemrograman blok, 68,2% merasa sangat menarik dan 31,8% tertarik. Secara keseluruhan, 63,6% peserta sangat tertarik dengan kegiatan, meskipun ada 10% yang merasa tidak tertarik. Dalam kegiatan ekstrakurikuler robotik dan coding, 68,2% peserta sangat tertarik dan 22,7% tertarik. Selain itu, terjadi peningkatan pemahaman siswa dengan kenaikan nilai sebesar 26% dari pre-test ke posttest. Kesimpulannya, pelatihan ini efektif dalam meningkatkan minat dan kompetensi STEM siswa, serta berpotensi menjadi model pembelajaran yang inovatif di tingkat dasar.
SISTEM INFORMASI BUKU TAMU PERPUSTAKAAN BERBASIS WEBSITE DI MUSEUM NEGERI NUSA TENGGARA BARAT
Authors: Huwae Raphael Bianco , Jatmika Andy Hidayat , Ratnasari Dwi , Rosika Herliana , Widyaswari Ni Made Rika Adi
Published: September 2024

Teknologi informasi berperan penting dalam meningkatkan efisiensi pengelolaan data di berbagai bidang, termasuk di Perpustakaan museum negeri Nusa Tenggara Barat (NTB), yang saat ini pencatatan masih dilakukan secara konvensional untuk data pengunjung. Dalam merancang dan membangun sistem informasi buku tamu perpustaan Museum Negeri NTB digunakan dengan metode pengembangan metode Waterfall. dimana dalam merancang sistem ini dibuat desain sistem berupa usecase diagram dan activity diagram. Pengujian sistem dilakukan dengan metode system usability scale dimana terdapat 10 pertanyaan yang diajukan kepada responden dan mendapat nilai akhir sebesar 92.5 sehingga dapat disimpulkan bahwa Sistem Informasi Buku Tamu Perpustakaan Museum NTB dapat di terima dengan baik oleh responden.
INSTALASI IRIGASI TETES BERTENAGA SURYA PADA PERTANIAN LAHAN KERING DESA GUMANTAR KABUPATEN LOMBOK UTARA
Authors: Zubaidi Ariyan , Wedashwara Wirarama , Jatmika Andy Hidayat , Mardiansyah Ahmad Zafrullah , Wijayanto Heri
Published: September 2024

Desa Gumantar, yang terletak di Kabupaten Lombok Utara, menghadapi tantangan besar dalam sektor pertanian karena kondisi lahan yang kering dan cuaca panas ekstrem. Rendahnya curah hujan dan distribusi air yang terbatas mengakibatkan kesulitan dalam pengelolaan sumber daya air, yang berdampak negatif pada produktivitas pertanian. Untuk mengatasi permasalahan ini, teknologi irigasi hemat air seperti sistem irigasi tetes sangat diperlukan untuk memaksimalkan penggunaan air secara efisien. Selain itu, pemanfaatan tenaga surya sebagai sumber energi alternatif dapat mendukung keberlanjutan pertanian dengan mengurangi ketergantungan pada bahan bakar fosil. Dalam kegiatan pengabdian masyarakat ini, dilakukan instalasi sistem irigasi tetes yang digerakkan oleh tenaga surya pada lahan pertanian di Desa Gumantar. Sistem ini menggunakan panel surya untuk menggerakkan pompa air yang menyalurkan air melalui pipa langsung ke akar tanaman. Hasil implementasi menunjukkan pengurangan biaya operasional yang signifikan, khususnya dalam pengeluaran solar, serta peningkatan produktivitas tanaman tomat dan cabai. Teknologi ini tidak hanya meningkatkan efisiensi penyiraman tetapi juga memberikan pengetahuan dan keterampilan baru kepada petani mengenai teknologi irigasi berkelanjutan yang ramah lingkungan dan efisien.
The Influence of Physical Fitness, Motor Skills, and Learning Motivation on Cartwheel Skills in Physical Education
Authors: Darma Hamda Putra , Bafirman Bafirman , Syahara Sayuti , Khairuddin Khairuddin , Rahman Dally , Zarya Fiky
Published: September 2024

Background Problems: During the observation, many students were unable to perform cartwheel skills. This research is important so that students can pass the minimum completion criteria so that their physical education learning outcomes are not low. Research Objectives: This study aims to determine the factors that influence the skills of cartwheel. Methods: This type of research is quantitative. The population amounted to 392 students in class XI. The technique used to obtain the sample is simple random sampling using the slovin formula with an error rate of 10%. Based on this, the sample amounted to 80 students. The physical fitness test instrument used the Indonesian Student Fitness Test, the motor ability test instrument used the Barrow Motor Ability Test, the learning motivation data was collected using a questionnaire, and the cartwheel skill data used an observation sheet which contained the criteria for implementing the cartwheel movement. Path analysis was used as a data analysis technique. Finding/Results: The results of the study consist of: 1. Physical fitness and motor skills have a significant influence on cartwheel skills. 2. Learning motivation has no significant effect directly on cartwheel skills. 3. Physical fitness indirectly through learning motivation has no significant effect on cartwheel skills. 4. Motor ability indirectly through learning motivation has no significant effect on cartwheel skills. Conclusion: Physical fitness and motor skills have a significant influence on cartwheel skills. Students need to do it outside of PJOK class hours. For Further Researchers Conduct research on other gymnastic movements.
Antioksidan in vivo buah beligo (Benincasa hispida (Thunb.) Cogn.) berdasarkan penurunan kadar malondialdehid tikus jantan wistar
Authors: Alim Nur , Irfayanti Nur Alfiah , Fajrianti Siti , Suarni Suarni , Jannah Raudatul
Published: September 2024

The aim is to ascertain the in vivo antioxidant activity of beligo fruit flesh ethanol extract based on the measurement of malondialdehyde levels in Wistar male rats generated by used frying oil. The procedure involves macerating 70% ethanol to extract the flesh from beligo fruit and assessing the in vivo antioxidant activity by measuring the amounts of malondialdehyde in fifty Wistar male rats split into 5 groups. Group V received vitamin C at a dose of 27 mg/kgBW, and groups II, III, and IV received an ethanol extract of beligo fruit flesh at 100, 200, and 400 mg/kg BW. Group I received 1% Na-CMC as a negative control. Using a UV-Vis spectrophotometer, malondialdehyde levels were determined using the TBARS test. Statistical data analysis by a Completely Randomized Design (CRD) and an Honestly Significant Difference (HSD) follow-up test. Malondialdehyde levels decreased in Group I (19.16%), Group II (78.70%), Group III (82.86%), Group IV (87.76%), and Group V (90.23%) according to the study's findings. The study findings demonstrated the antioxidant potential of beligo fruit flesh ethanol extract at doses of 100 mg, 200 mg/kg BW (p<0.05), and 400 mg/kg BW (p<0.01) in lowering malondialdehyde levels in Wistar male rats.
Influence of extraction method on total phenolic content and antioxidant activity of Sappan Wood (Caesalpinia sappan L.) extract
Authors: Akmal Tubagus , Tanjung Yenni Puspita , Julianti Andi Ika , Lestari Aulia Gustiani , Aljan Aljan
Published: September 2024

Sappan wood is a botanical species that contains a high concentration of phenolic compounds, which contribute to several pharmacological properties, including antidiabetic, antibacterial, antioxidant, and wound-healing activities. In order to achieve phenolic compounds of high quality and quantity, it is crucial to select an appropriate extraction procedure. Plant extraction is an important step for chemical isolation, chemical analysis, and evaluating the biological and pharmacological activities of plant compounds. Therefore, determining the most favorable extraction conditions is a critical undertaking in order to maximize both the quantity of active plant compounds and the extraction yield. This research aimed to compare extraction methods based on total phenolic content (TPC) and antioxidant activity (IC50). The extraction techniques employed include maceration, stirring-assisted extraction (SAE), ultrasound-assisted extraction (UAE), and microwave-assisted extraction (MAE). The results show TPC values for maceration, SAE, UAE, and MAE, which are 132.85±1.44, 150.99±1.69, 206.70±6.56, and 115.70±1.44 mg GAE/g DE, respectively. The DPPH antioxidant activity (IC50) values are 32.33±2.64, 25.01±0.34, 20.68±0.29, and 29.18±0.70 µg/mL, respectively. The research findings indicate that various extraction procedures can impact the extraction yield, total phenolic content (TPC), and antioxidant activity (IC50) of sappan wood, and UAE is the best extraction method.
TOPOGRAFIA E SOFTWARE LIVRE: UMA ANÁLISE CRÍTICA SOBRE O USO DO QGIS COMO FERRAMENTA PEDAGÓGICA E DE TRABALHO DOS TOPÓGRAFOS MILITARES DO EXÉRCITO BRASILEIRO
Authors: Franqueira Alberto da Silva
Published: September 2024

O Exército Brasileiro (EB), da guerra dos Guararapes até hoje, ouvimos histórias militares, com foco na parte bélica do assunto. Nesse sentido, pouco falamos da formação, sobre a base educacional. O EB é composto por ‘armas', ‘quadros' e ‘serviços', dentre os citados pretendo discorrer sobre o ‘serviço de topografia', que trabalha com a cartografia focando em mostrar a importância do uso do software QGIS na formação e pós-formação desses topógrafos. Daí surgiu o seguinte questionamento: De que forma a utilização do QGIS pode influenciar na aprendizagem, da formação até a pós-formação, dos topógrafos do EB? É objetivo geral analisar o uso do software QGIS na formação e pós-formação em Topografia, visando a educação militar, sendo uma ferramenta de ensino e de trabalho aos topógrafos; e específicos são: Apresentar o serviço de topografia; descrever os tópicos da disciplina cartografia e Sistemas de Informações Geográficas; demonstrar o uso do QGIS, como prática pedagógica, e verificar sua utilização, perspectivas e aplicação junto aos militares topógrafos. Para responder à pergunta da pesquisa utilizei uma metodologia de abordagem qualiquantitativa, sendo um estudo de caso, utilizando documentos oficiais e contando com um questionário semiestruturado, pretendendo mostrar a opinião desses militares e a influência desse software em suas vidas na caserna. Com os resultados obtidos foi possível observar como o QGIS influencia na aprendizagem e na vida do topógrafo, independente se está ainda nos bancos escolares, trabalhando nos Centros de Geoinformação ou em outras organizações militares espalhadas por todo território brasileiro.
Evolution of research in the Pharmacology Laboratory at the Universidad Autónoma Metropolitana-Iztapalapa: A Historical Review
Authors: Alarcon-Aguilar Francisco Javier , Almanza-Pérez Julio Cesar , Blancas-Flores Gerardo , Flores-Sáenz José Luis Eduardo , Fortis-Barrera María de los Ángeles , Giacoman-Martínez Abraham , Román-Ramos Rubén
Published: September 2024

This paper aims to trace essential milestones in the history of the investigation activities developed throughout the past four decades in the Laboratory of Pharmacology of the Universidad Autónoma Metropolitana Iztapalapa (LFUAMI), emphasizing the contribution of Dr. Rubén Román-Ramos, the leader who guided and promoted the chemical and pharmacological investigation of natural products in the LFUAMI. Dr. Rubén Román-Ramos impacted the development of new generations, who continue contributing to and strengthening this field, both outside and inside our university, by developing the science and technology in chemistry and pharmacology research. From this historical review of the LFUAMI, it is possible to identify leading features in its different periods; the periods are characterized by the scientific evidence primary generated, the methodological impact in the results, and technological development and impact in the state of the art. It should be noted that the periods overlap, creating a cumulative effect. To conclude, we will summarize the historical milestones and present some research avenues currently pursued and some perspectives.
 
Resumen. Este artículo es una revisión acerca de la investigación desarrollada durante los últimos 40 años en el Laboratorio de Farmacología de la Universidad Autónoma Metropolitana Iztapalapa (LFUAMI), enfatizando la contribución del Dr. Rubén Román Ramos, profesor quien guió y promovió la investigación químico-farmacológica de este laboratorio, impactando en la formación de nuevas  generaciones de investigadores, quienes continúan su legado en la investigación de productos naturales, fortaleciéndolo, tanto dentro como fuera de nuestra universidad. A través de esta revisión histórica fue posible identificar algunas de las características sobresalientes de cada periodo del LFUAMI en las últimas cuatro décadas, destacando la calidad de la evidencia científica generada, la influencia metodológica y el desarrollo tecnológico de los distintos estudios, así como su impacto en el estado del arte. Para concluir, se resumen algunos de los desarrollos más relevantes, se presentan algunas de los trabajos recientes y las perspectivas de investigación más importantes de este consolidado grupo de trabajo.
Gaining Insights into Folding/Unfolding Protein Structures and their Importance for Several Applications: Historical Research Generated in the Biophysical Chemistry Area
Authors: Rojo-Domínguez Arturo , Herrera-Zuñiga Leonardo D.
Published: September 2024

The research largely focuses on investigating the mechanisms of protein folding and unfolding in proteins, namely triosephosphate isomerase, glucosamine-6-phosphate deaminase, laccase, and bacteriophage M13. The article examines the mechanisms of protein denaturation and renaturation using kinetic equations, thermodynamic models, and molecular dynamics (MD) simulations. These results enhance our understanding of the thermodynamic and kinetic characteristics of these proteins. Furthermore, the study highlights the importance of conserved residues, as well as the influence of environmental conditions such as pH and temperature on protein stability and folding. These discoveries have potential implications in biotechnology and medicine, including the creation of protein-based products and therapies for infectious diseases, and neurodegenerative disorders. The paper acknowledges the groundbreaking contributions of Dr. Andrés Hernández Arana to the field of protein physical chemistry in México. His work has greatly influenced the progress of research in the areas of protein stability and kinetics.
 
Resumen. La investigación se centra en los mecanismos de plegado y desplegado de proteínas; estos mecanismos incluyen la triosafosfato isomerasa, la glucosamina-6-fosfato desaminasa, lacasa y el bacteriófago M13. Se utilizan ecuaciones cinéticas, modelos termodinámicos y simulaciones de dinámica molecular (MD) para analizar los mecanismos de desnaturalización y renaturalización de proteínas. Estos hallazgos nos ayudan a comprender mejor las características cinéticas y termodinámicas de estas proteínas. Además, el estudio destaca la importancia de los residuos conservados y puentes salinos en las proteínas, así como el impacto de los factores ambientales como el pH y la temperatura en la estabilidad y el plegado de las proteínas. Estos hallazgos tienen repercusiones en los campos de la biotecnología y la medicina, como la creación de productos y terapias basados en proteínas para enfermedades infecciosas y trastornos neurodegenerativos. El artículo reconoce el trabajo pionero del Dr. Andrés Hernández Arana en México en el campo de la termodinámica de proteínas. Su trabajo ha sido fundamental para el avance de la investigación en las áreas de cinética y estabilidad de proteínas.
Mexican Contribution to Sulfide Minerals Electrochemistry: A Review
Authors: Cruz Roel , Lázaro Isabel
Published: September 2024

The electrochemical study of sulfide minerals has emerged as a vital area for enhancing sustainable methods for extraction and recovery of metals. This field encompasses diverse investigations. The use of Mineral Carbon Paste Electrodes (CPE) is one of the strategies developed in México, and their application for analyzing systems of extractive metallurgy range from analyses of bacterial-mineral interactions to key studies that have delved into understanding mineral dissolution mechanisms, with a particular focus on minerals such as galena, sphalerite, copper sulfides, and silver minerals. In addition, research efforts have been directed towards exploring copper and zinc concentrates leaching, as well as cyanidation refractoriness. These studies aim to advance extraction efficiency and sustainability in the mining industry.
 
El estudio electroquímico de los minerales de sulfuro ha surgido como un área vital para mejorar los métodos de extracción y recuperación de metales de manera sostenible. Este campo abarca diversas investigaciones. La utilización de electrodos de pasta de carbono (CPE) es una de las estrategias desarrolladas en México, y su aplicación para analizar sistemas de metalurgia extractiva abarca desde análisis hasta interacciones bacteria-mineral. Estudios clave se han centrado en comprender los mecanismos de disolución mineral, con un enfoque particular en minerales como la galena, la esfalerita, los sulfuros de cobre y los minerales de plata. Además, los esfuerzos de investigación se han dirigido a explorar la lixiviación de concentrados de zinc y la refractariedad a la cianuración. Estos estudios tienen como objetivo avanzar en la eficiencia y sostenibilidad de la extracción en la industria minera.
Literacia digital em saúde: convergências, divergências e possíveis caminhos para um campo em evolução
Authors: Souza Nicole Fajardo Maranha Leão de
Published: September 2024

A evolução da saúde digital e a (des)infodemia demandam que os cidadãos tenham capacidades que vão além do domínio instrumental dos dispositivos tecnológicos. A literacia digital em saúde compreende as habilidades para encontrar, compreender e avaliar as informações de saúde disponíveis on-line, utilizando-as para resolver problemas dessa ordem. A escala mais utilizada para medir essa competência é a eHealth Literacy Scale (eHEALS). O objetivo deste artigo é compreender as principais convergências e divergências acadêmicas em torno da literacia digital em saúde e da eHEALS. Por meio de um levantamento bibliográfico, também analisamos como são abordados os diferentes contextos sociais em que a literacia digital em saúde se desenvolve. Concluímos tratar-se de um campo que ainda carece de estudos que discutam, ampliem e validem sua dimensão social, rumo a uma literacia digital crítica em saúde.
Suicídio na mídia: uma cartografia do suicídio de Jéssica Canedo a partir de normas de cobertura responsável
Authors: Oliveira Filho José Tarcísio Silva , Antunes Débora
Published: September 2024

A pesquisa recorre ao método cartográfico de Rosário e Coca para refletir sobre o suicídio nos campos midiático e jornalístico. Para isso, analisa a responsabilidade midiática e a construção do suicídio pelo jornalismo no caso Jéssica Canedo, uma jovem de 22 anos que se matou após publicação de uma conversa falsa com o humorista Whindersson Nunes. O conteúdo foi amplamente divulgado por perfis em sites de redes sociais, entre elas o Choquei, no Instagram. Foram selecionadas 51 matérias jornalísticas, de nove jornais, que noticiaram o caso. Elas foram analisadas por meio de um quadro com orientações de instituições de Saúde e de empresas de mídia para a cobertura responsável do suicídio, além da análise de discurso. A pesquisa demonstrou que o jornalismo mantém uma cobertura deficiente sobre o acontecimento e que o amplo acesso às plataformas de redes sociais traz novas preocupações no que tange à responsabilidade midiática.
The role of Helicobacter pylori in the development of inflammatory eyelid diseases
Authors: Kazantseva E. P. , Frolov A. M. , Frolov M. A. , Novikova E. A. , Mugulov K. S. , Kozlova K. S. , Volchanskiy K. I. , Maximova S. A. , Pilipenko M. O.
Published: September 2024

Background. Blepharitis is one of the most common eye diseases: it accounts for 23.3 % of the total number of patients with inflammatory eye diseases worldwide. 40.2 % of these patients seek outpatient care. The incidence of blepharitis is 1.5–2 times higher in women than in men. The leading factors in the development of blepharitis are both general (gastrointestinal tract diseases, diabetes mellitus, hypertension, systemic use of corticosteroids, etc.) and local (atopic and seborrheic dermatitis or rosacea). The main causative agents of this disease are Staphylococcus spp. (S. aureus, S. epidermidis). As a rule, the disease manifests itself in patients aged 30–50 years, while in women aged 40 to 45 years, 80 % of blepharitis are of staphylococcal origin. Currently, there are reports in the literature about apotential link between Helicobacter pylori infection and the development of chronic blepharitis, but the data are very contradictory.

The aim of the study. To analyze the features of the relationship between Helicobacter pylori and inflammatory eyelid diseases.

Materials and methods. We conducted a search and analysis of literary sources in the Web of Science, PubMed and Google Scholar databases, as well as in the Russian Science Citation Index database for the period from 2000 to 2022.

Conclusion. The review analyzes and summarizes the pathogenic mechanisms of the relationship between chronic blepharitis and Helicobacter pylori. We carried out an analysis of numerous studies, which give grounds to assume a possible role of Helicobacter pylori infection in the development and course of inflammatory eyelid diseases (blepharitis). The main pathogenic aspects in these studies are: chronic inflammation of the eyelids and gastrointestinal tract (antigenic mimicry); excretion of toxic substances from the oral cavity (ammonia, hydrogen nitrite, hydrogen cyanide and other substances causing indirect inflammation of the conjunctiva and eyelid cartilage); the presence of Helicobacter pylori in tears.
Some correlates of body dissatisfaction in urban school students
Authors: Pogodina A. V. , Astakhova T. A. , Lebedeva L. N.
Published: September 2024

Background. Body dissatisfaction is widely spread among the population. It negatively affects human health, contributing to the development of eating disorders, anxiety and depressive disorders, and the formation of unhealthy eating patterns and lifestyle. Determining the factors associated with body dissatisfaction in adolescents may be important for the prevention of the above mentioned disorders.

The aim of the work. To describe the prevalence, characteristics and factors associated with body dissatisfaction among urban school students.

Materials and methods. Tenth-grade school students (n = 440) underwent anthropometry and also filled out questionnaires including socio-demographic factors and lifestyle factors. Collins scales were used to assess body dissatisfaction, and the Russian version of the Paediatric Quality of Life Inventory (PedsQL 4.0; Lyon, France) was used to assess health-related quality of life.

Results. 60.2 % of school students reported a desire to have body figures different from the actual one. 42.7 % of adolescents experienced mild body dissatisfaction, 17.5 % experienced moderate and severe body dissatisfaction. The frequency of body dissatisfaction was comparable among both male and female adolescents, but it was more pronounced among girls compared to boys (Z = 2.2; p = 0.029). Boys were significantly more likely than girls to strive for larger body figures than what they felt they had (38.8 % vs. 8.1 %). In contrast, girls were significantly more likely than boys to want to lose weight (55.4 % vs. 12.3 %). Statistically significant associations with moderate/severe body dissatisfaction are shown for overweight/ obesity and for the time spent by schoolchildren watching TV, on social networks, and in the Internet. Sports activities demonstrated a protective role in relation to body dissatisfaction. The presence of body dissatisfaction significantly reduced all aspects of adolescents’ quality of life.

Conclusions. The results of the study justify the approach to body dissatisfaction as an independent problem that requires active diagnostics and targeted exporure, and determine possible directions for preventive measures among adolescents.
The relationship between the group processes characteristics and changes in the functional state of participants of a marine scientific expedition to the Arctic
Authors: Trofimova A. A. , Korneeva Ya. A. , Simonova N. N. , Agafonova A. S.
Published: September 2024

Background. In the conditions of an Arctic expedition, people’s physical and mental health are affected not only by extreme climatic and geographical factors, but also by social and living conditions caused by group isolation. Comfort psychological atmosphere in an isolated team, its group cohesion and motivation are an environmental resource for expedition participants and contribute to maintaining optimal functional state throughout the entire shift period.

The aim of the work. To identify and to describe group cohesion, group motivation and psychological atmosphere in the team as the parameters of group dynamics of "Arctic Floating University – 2023" expedition participants in connection with changes in their functional state during the shift period.

Methods. We used V.A. Rozanova’s "Group motivation", C.E. Seashore’s "Group Cohesion Index", and A.F. Fiedler’s "Team’s psychological atmosphere" questionnaires; psychophysiological testing on the UPFT-1/30 "Psychophysiologist" device (variational cardiologic intervalometry, complex eye-hand reaction); M. Lüscher color test; statistical methods: descriptive statistics and correlation analysis using the Spearman coefficient. Follow-up monitoring of the functional state and group dynamics parameters of the expedition participants was carried out once every two days during the entire expedition period. 42 participants of the "Arctic Floating University – 2023" project took part in the study.

Results. The functional state of the participants in the maritime Arctic expedition during the entire expedition period was characterized by acceptable and nearoptimal values, a sufficient level of performance efficiency, an average level of physical condition, the absence of signs of severe stress, and an average level of subjective comfort. Group cohesion, group motivation, and the psychological atmosphere in the team increase from the beginning to the end of the expedition period, and on the days 21–22, they have the highest levels compared to all days of the expedition. Mostly direct correlations were revealed between group processes and changes in the functional state of expedition participants.

Conclusion. A positive relationship was established between group cohesion, group motivation and psychological atmosphere in the team and the parameters of the functional state of the expedition participants.
Depersonalization-derealization symptom complex in the clinic of manifest forms of schizophrenia
Authors: Lobkov S. A.
Published: September 2024

Background. The issues of early diagnostics and prevention of schizophrenia, despite more than a century of their study, remain relevant. In recent decades, there has been an increase in interest in the study of depersonalization-derealization symptom complex in the context of verification of the initial manifestations of the disease. Meanwhile, ICD-10 does not include symptoms of depersonalization and derealization in the rank of diagnostically important symptoms for this pathology, and they are traditionally considered as manifestations of schizotypal disorders. The existing contradictions suggest the need for further study of depersonalization and derealization in the clinic of manifest forms of schizophrenia.

The aim of the study. To assess the prevalence and clinical manifestations of depersonalization-derealization in paroxysmal forms of schizophrenia.

Materials and methods. The study included 40 patients with depersonalization-derealization symptoms in the clinical picture of manifest forms of schizophrenia. Typological groups were represented by paranoid schizophrenia with an attack-like or continuous course (18 people) and schizoaffective disorder (22 people). We used such research methods as clinical follow-up, clinical and anamnestic, clinical and psychopathological, and also the Cambridge Depersonalization Scale.

Results. Manifestations of depersonalization-derealization at the pre-manifest stage of the disease were observed in 82.5 % of the study cohort. In most cases, mild and moderate severity was detected – in 37.5 and 42.5 %, respectively; severe form was found only in 20 % of patients. In 17.5 % of cases, manifestations of depersonalization and derealization were periodic, and in the majority (65 %) of patients they were persistent. Almost 1/3 of patients had total depersonalization, 22.5 % had only autopsychic and allopsychic depersonalization, and 17.5 % of cases had isolated somatopsychic depersonalization. An association was found between the severity of depersonalization-derealization and paranoid syndrome. During the disease, as negative disorders increase, the manifestations of depersonalization-derealization are reduced.

Conclusion. The obtained data demonstrate the need for further studying depersonalization symptom complex in the clinic of manifest forms of schizophrenia in the aspect of prognosis of the clinical course of the disease.
Dynamics of perifocal reactions to the application of antimicrobial gel in one-stage hip replacement under conditions of staphylococcal infection in the experiment
Authors: Bozhkova S. A. , Korneva Yu. S. , Liventsov V. N. , Legonkova O. S. , Anisimova L. O. , Netylko G. I. , Gadzhimagomedov M. Sh. , Akhmedov B. G.
Published: September 2024

Background. Local antibacterial therapy in the treatment of osteomyelitis significantly increases the effectiveness of surgical debridement.

The aim of the work. To assess in an in vivo experiment the dynamics of perifocal tissue reactions to the application of an original polyvinylpyrrolidone-based antimicrobial gel in a one-stage treatment of implant-associated infection in the hip joint in rabbits.

Methods. Implant-associated infection was modeled by inserting Staphylococcus aureus-infected wires into the medullary canal of the femur of rabbits (n = 12). On the day 14, we removed the wire and performed radical surgical treatment of the suppurative focus and hip replacement. The animals were divided into two groups: experimental group – with application of the original antimicrobial gel at the stage of hip replacement (n = 6); comparison group – without gel application (n = 6). For morphological studies, animals were sacrificed on the days 10, 45 and 90 after hip replacement, changes in soft tissues and the bone marrow canal were assessed, and cell populations were counted with statistical data processing.

Results. The application of the original antimicrobial gel causes statistically significant decrease in the number of neutrophils in the soft tissues surrounding the implant in the comparison group at all stages. Moreover, in the experimental group, at early stages the number of lymphocytes, plasmacytes and macrophages was statistically significantly higher; on the day 45, a statistically significantly larger number of lymphocytes was registered, and on the day 90 – a statistically significantly larger number of multinucleated and epithelioid cells.

Conclusion. The experiment histologically confirmed the effectiveness of application of the original antimicrobial gel to stop infectious inflammation in soft tissues and the bone marrow canal during surgical debridement of an osteomyelitic lesion followed by hip replacement. A pronounced giant cell reaction aimed at removing the polyvinylpyrrolidone-based gel requires further research in terms of its outcomes.
Epidemiology of complications in anesthesiology and possible ways of their prevention
Authors: Ziganshin A. M. , Marakanov R. M. , Mulyukov A. R. , Baboyan D. O. , Nadyrgulov R. B. , Gilyazitdinov N. M.
Published: September 2024

Increase in life expectancy in the world leads to an increase in the number of patients with multimorbidity who will require surgical intervention and anesthesia in the future. The desire of specialists to meet the high standards of clinical guidelines when performing medical interventions is often associated with the risk of complications, especially when providing emergency medical care. Complications during surgical interventions and anesthesia can be observed in institutions of any level and when providing care by any specialists.

The aim. To assess the main risk factors that can cause complications when providing anesthesia.

Materials and methods. The study was conducted in accordance with international reporting requirements for reviews (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). The search was performed in PubMed and Cochrane Controlled Clinical Trials Register. The method of searching by references was used to select the articles. The search strategy did not include limitations of the language, type and date of the article. Inclusion criteria: full-text publications devoted to the influence of risk factors on the incidence of complications when providing anesthesia care. Exclusion criteria: brief summaries; abstracts without a full-text version; publications without key words.

Results. The review assessed the most common risk factors causing complications during anesthesia and ways to reduce them.
Beijing Central Asian Outbreak strain cluster of Mycobacterium tuberculosis detected in Irkutsk region, Russia
Authors: Zhdanova S. N. , Kondratov I. G. , Ogarkov O. V.
Published: September 2024

Background. Irkutsk region maintains a high incidence rate of multidrug-resistant (MDR) tuberculosis (TB). Detection of MDR-associated Mycobacterium tuberculosis strains in Irkutsk region requires dynamic assessment of the TB pathogen population, taking into account the emergence of a new resistant variant of Beijing Central Asian Outbreak (CAO).

The aim of the study. To assess changes in the genotypic structure of M. tuberculosis strains circulating in the Irkutsk region over a ten-year period.

Materials and methods. A total of 732 M. tuberculosis strains (196 strains for 2021– 2022, 536 strains for 2011–2015) were studied using MIRU-VNTR and SNP typing.

Results. The MDR level increased to 67.4 % with an increase of pre-extensive drug resistance (pre-XDR) (33.2 %) (p < 0.001). In the modern sample, the dominance of the Beijing genotype increased (83.7 %) due to an increase in the proportions of the B0/W148 (38.8 %) and CAO (12.8 %) subtypes with a stable overall level of Central Asian Russian (36.8 %) and other Beijing strains (8.2 %). Strains other than the Beijing genotype belonged mainly to the Euro-American lineage (Lineage 4): LAM (8.9 %), Ural (2.7 %), Haarlem (2.0 %), S (0.5 %) and L4-unclassified (5.3 %); 25 isolates were not classified. In the 2011–2015 sample, LAM was more common than in the modern sample (10.8 % vs. 3.6 %; p < 0.01). The increase in MDR and preXDR was statistically significant among Beijing B0/W148 strains (93.4 % vs. 66.1 %; p < 0.001).

Conclusion. Unfavorable trends of significant spread of MDR and pre-XDR of the Beijing genotype strains were revealed. Among the Beijing strains, not only B0/W148 but also the Beijing CAO subtype, which was previously rare in Siberia, are the most successful; they have the highest levels of MDR and pre-XDR and a tendency to widespread distribution in all groups of TB patients.
Changes in the level of immune checkpoints in patients with various forms of autoimmune thyroiditis
Authors: Babinsky V. V.
Published: September 2024

Background. Autoimmune thyroiditis (AIT) affects more than 5 % of the world’s population.

The aim. To determine the level of sPD-1, sPD-L1, sCTLA-4 and sB7.2 molecules in individuals suffering from various forms of autoimmune thyroiditis.

Methods. The study included 31 individuals aged 18 to 40 years. They were divided into four groups: group I – healthy individuals (n = 10); group II – carriers of antibodies to thyroid peroxidase (n = 11); group III – individuals with AIT accompanied with subclinical form of hypothyroidism (n = 6); group IV – individuals with AIT complicated by compensated hypothyroidism (n = 4). Venous blood was collected to determine the level of antibodies to thyroid peroxidase using enzyme immunoassay, the concentration of thyroid stimulating hormone and free thyroxine – using chemiluminescence immunoassay, and the levels of sPD-1, sPD-1L, sCTLA-4, and sB7.2 – using flow cytofluorometry. Statistical processing was performed using the Kruskal – Wallis one-way analysis of variance.

Results. When comparing the level of sPD-1L in groups I (54.1 (28.7; 67.6) pg/ml) and II (4.36 (2.36; 18.0) pg/ml), the decreased in this indicator was 91.94 % (p = 0.001). When comparing the sPD-1 level in the group of healthy individuals (16.6 (13.6; 37.2) pg/ml) and group IV (7.28 (5.18; 11.1) pg/ml), werecorded a decrease of 56.14 % (p = 0.001). The sB7.2 concentration decreased by 65.03 % in group II (16.4 (15.6; 32.7) pg/ml) compared to the control group (46.9 (39.3; 54.4) pg/ml) (p = 0.001). In group III, the sCTLA-4 level was 3.22 (3.06; 3.33) pg/ml and decreased by 88.66% compared to the control group (p = 0.001).

Conclusion. The development of autoimmune thyroiditis is accompanied with the decrease in the concentration of sPD-1, sPD-1L, sCTLA-4 and sB7.2.
Pathogenesis of respiratory failure in COVID-19 due to coagulopathy and endothelial dysfunction
Authors: Burdienko T. O.
Published: September 2024

Respiratory failure is known to be the main clinical manifestation of COVID-19. However, the mechanism of its development has not been sufficiently studied. The originality of the study is that for the first time, coagulation, fibrinolysis and endothelial dysfunction indicators were studied depending on the SpO2/FiO2 index in patients with COVID-19.

The aim of the work. To assess the role of impaired activity of the blood coagulation system and the development of endothelial dysfunction in patients with COVID-19 in the pathogenesis of respiratory failure.

Methods. The study included 134 patients infected with SARS-CoV-2 virus having varying severity of the clinical picture. They were divided into three groups according to the SpO2/FiO2 index. We determined the number of venous blood cells and studied the level of transferrin (TF), D-dimer, tissue-type plasminogen activator (tPA), plasminogen activator inhibitor-1 (PAI-1), inter-cellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) in the blood serum.

Results. The study revealed that the tissue factor content increased by 24 % in patients of the third group compared to the first. The PAI-1 level was high in the second group and significantly decreased in the third (p < 0.001). An increase in the D-dimer level was recorded in the second and third groups. The levels of ICAM-1 and VCAM-1 molecules increased significantly in the third group of patients (p = 0.021 and p = 0.028, respectively). A moderate positive correlation was found between the SpO2/FiO2 index and the VCAM-1 level (p < 0.001), a weak positive correlation with PAI-1 (p = 0.012), and a weak negative correlation with TF (p = 0.027).

Conclusion. Respiratory failure in patients with COVID-19 is caused by disorders in the hemostasis and fibrinolysis systems, as evidenced by an increase in the level of tissue factor and D-dimer, “consumption” of tissue activator and plasminogen activator inhibitor. Developing endothelial dysfunction, accompanied by increased secretion of adhesion molecules, aggravates the pathogenesis of respiratory failure.