bluuebunny/crossref_metadata_2025 huggingface dataset:
Grazing resistance allows bloom formation and may explain invasion success of Gonyostomum semen
Authors: Lebret Karen , Fernández Fernández María , Hagman Camilla H. C. , Rengefors Karin , Hansson Lars-Anders
Published: April 2012

The nuisance alga Gonyostomum semen (Raphidophyceae) has expanded in the Nordic countries during the last decades and can dominate lake phytoplankton communities almost completely. A possible explanation to its dominance could be limited grazing by zooplankton. We investigated the potential grazing pressure on G. semen using an experimental approach supported by field data. We determined the grazing rate by cladocerans, calanoid copepods, and Chaoborus larvae to determine which were able to feed on G. semen. Only the large cladoceran Daphnia magna was able to feed successfully on G. semen. The large cell size of G. semen was likely a limiting factor for the filtering apparatus of smaller cladocerans. The copepod Eudiaptomus gracilis did not graze on G. semen, although the mechanism behind this selective feeding is still unknown. In addition to the experimental study, we quantified the zooplankton and phytoplankton communities in 40 lakes to determine the composition and abundance of the zooplankton communities co‐occurring with G. semen, suggesting that large cladoceran species were not present in lakes where G. semen occurred. Hence, the growth of G. semen is not significantly controlled by grazing in natural systems, which likely facilitates bloom formation and invasion success of G. semen.
Initial investigation of the wavelength dependence of optical properties measured with a new multi-pass Aerosol Extinction Differential Optical Absorption Spectrometer (AE-DOAS)
Authors: Chartier R. T. , Greenslade M. E.
Published: April 2012

Abstract. Atmospheric aerosols directly affect climate by scattering and absorbing radiation. The magnitude of the impact is dependent upon the wavelength of light, but is often estimated near 550 nm. When light scattering and absorption by aerosols is approximated, the wavelength dependence of the refractive index for specific components is lost. As a result, climate models would have inherent uncertainties for aerosol contributions to radiative forcing when considering the entire solar spectrum. An aerosol extinction differential optical absorption spectrometer has been developed to directly measure aerosol extinction at mid-ultraviolet to near infrared wavelengths. The instrument consists of a spectrometer coupled to a closed White-type multi-pass gas cell with an adjustable path length of up to approximately 20 m. Laboratory measurements of various gases are compared with known absorption cross sections. Additionally, the extinction of monodisperse samples of polystyrene latex spheres are measured and compared to Mie theory generated with refractive index values from the literature to validate the new instrument. The polystyrene experiments also emphasize the ability of the new instrument to retrieve the wavelength dependent refractive index, especially in the ultraviolet wavelength regions where variability is expected. The spectrometer will be a significant advancement for determining wavelength dependent complex refractive indices in future laboratory studies as well as provide the ability to monitor ambient aerosol light extinction.
Uncertainties in the global temperature change caused by carbon release from permafrost thawing
Authors: Burke E. J. , Hartley I. P. , Jones C. D.
Published: April 2012

Abstract. Under climate change thawing permafrost will cause old carbon which is currently frozen and inert to become vulnerable to decomposition and release into the climate system. This paper develops a simple framework for estimating the impact of this permafrost carbon release on the global mean temperature (P-GMT). The analysis is based on simulations made with the Hadley Centre climate model (HadGEM2-ES) for a range of representative CO2 concentration pathways. Results using the high concentration pathway (RCP 8.5) suggest that by 2100 the annual methane (CH4) emission rate is 2–59 Tg CH4 yr−1 and 50–270 Pg C has been released as CO2 with an associated P-GMT of 0.08–0.36 °C (all 5th–95th percentile ranges). P-GMT is considerably lower – between 0.02 and 0.11 °C – for the low concentration pathway (RCP2.6). The uncertainty in climate model scenario causes about 50% of the spread in P-GMT by the end of the 21st century, indicating that the effect of permafrost thaw on global mean temperature is currently controllable by mitigation measures. The distribution of soil carbon, in particular how it varies with depth, contributes to about half of the remaining spread in P-GMT by 2100 with quality of soil carbon and decomposition processes contributing a further quarter each. These latter uncertainties could be reduced through additional observations. Over the next 20–30 yr, whilst scenario uncertainty is small, improving our knowledge of the quality of soil carbon will contribute significantly to reducing the spread in the, albeit relatively small, P-GMT.
Hepatocyte Labeling with 99mTc-GSA: A Potential Non-Invasive Technique for Tracking Cell Transplantation
Authors: Chouhan Manil , Puppi Juliana , Solanas Estela , Mitry Ragai R. , Dhawan Anil , Hughes Robin D.
Published: April 2012

Background:

Hepatocyte transplantation is a promising alternative to orthotopic liver transplantation, however, the fate of transplanted hepatocytes is not well defined. 99mTc-galactosyl-serum albumin (99mTc-GSA) is a clinical scintigraphic agent which is specifically taken up by the hepatocyte asialoglycoprotein receptor (ASGPR).

Aims:

To investigate labeling of fresh and cryopreserved human hepatocytes and fresh rat hepatocytes in vitro using 99mTc-GSA

Methods:

Human and rat hepatocytes were isolated from liver tissue by collagenase perfusion. The ASGPR were characterized using immunohistochemistry and RT-PCR. Hepatocytes were incubated with 99mTc-GSA in suspension at 4°C and 37°C. Cell viability and function was determined using cell mitochondrial dehydrogenase (MTS) and sulphorhodamine B (SRB) assays.

Results:

Fresh and cryopreserved human hepatocytes expressed the ASGPR. Incubation of hepatocytes in suspension with 99mTc-GSA reduced the viability of hepatocytes, but this was similar to unlabeled control cells. Greater loss of viability was seen on incubation at 37°C compared to 4°C, but there was a significantly greater uptake of 99mTc-GSA at the physiological temperature (6.6 ± SE 0.6-fold increase, p<0.05) consistent with ASGPR-mediated endocytosis. MTS and SRB assays were not significantly affected by labeling with 99mTc-GSA in all three cell types. A mean of 18.5% of the radioactivity was released over 120 min when 99mTc-GSA - labeled hepatocytes were shaken in vitro at 37°C.

Conclusions:

Human and rat hepatocytes can be labeled with 99mTc-GSA, which may have potential application for in vivo imaging after hepatocyte transplantation.
Approximate l-States of the Manning-Rosen Potential by Using Nikiforov-Uvarov Method
Authors: Ikhdair Sameer M.
Published: April 2012

The approximately analytical bound state solutions of the l-wave Schrödinger equation for the Manning-Rosen (MR) potential are carried out by a proper approximation to the centrifugal term. The energy spectrum formula and normalized wave functions expressed in terms of the Jacobi polynomials are both obtained for the application of the Nikiforov-Uvarov (NU) method to the Manning-Rosen potential. To show the accuracy of our results, we calculate the eigenvalues numerically for arbitrary principal and orbital quantum numbers n and l with two different values of the potential screening parameter α. It is found that our results are in good agreement with the those obtained by other methods for short potential range, lowest values of orbital quantum number l, and α. Two special cases of much interest are investigated like the s-wave case and Hulthén potential case.
Meeting the Needs of People with Primary Progressive Multiple Sclerosis, Their Families, and the Health-Care Community
Authors: Holland Nancy J. , Schneider Diana M. , Rapp Robert , Kalb Rosalind C.
Published: April 2012

Although major advances have been made in delaying or preventing progression for the relapsing forms of multiple sclerosis (MS), little progress has been made to date in disease management for primary progressive MS (PPMS). Treatment strategies are largely focused on managing the symptoms of the disease and providing counseling and other forms of psychosocial support. The nurse plays a major role in managing these patients. This article summarizes a collaborative effort by the National Multiple Sclerosis Society and the Multiple Sclerosis Association of America to analyze the needs of this patient population and respond with programs that will meet those needs. This approach to developing a needs assessment is broadly applicable to other patient populations.
Effect of Eszopiclone on Sleep Disturbances and Daytime Fatigue in Multiple Sclerosis Patients
Authors: Attarian Hrayr , Applebee Garrick , Applebee Angela , Wang BingXia , Clark Melissa , McCormick Becky , Salzman Emma , Schuman Catherine
Published: April 2012

The prevalence of moderate-to-severe sleep problems is significantly higher among people with multiple sclerosis (MS) than in the general population. In 2002, we found a significant relationship between fatigue and disrupted sleep in patients with relapsing-remitting MS (RRMS). The objectives of this study were to determine whether eszopiclone (Lunesta; Sunovion Pharmaceuticals Inc, Marlborough, MA) was superior to placebo in improving sleep among patients with MS-related fatigue and sleep complaints (primary end point); and to assess the impact of improved sleep on daytime fatigue and functioning (secondary end point). This was a double-blind, placebo-controlled pilot trial lasting 7 weeks. Thirty ambulatory adults under age 65 years with RRMS, fatigue, and sleep disturbances were randomized to receive either eszopiclone or placebo. The outcome measures included subjective and objective changes in sleep-onset latency (SOL), total sleep time (TST), wakefulness after sleep onset (WASO), sleep efficiency (SE), fatigue scales, and neuropsychological measures of daytime functioning. Compared with placebo, eszopiclone was superior only in increasing TST. Fatigue improved in both groups, but there was no statistically significant correlation between increased TST and improved fatigue, and no statistically significant differences were observed between the two groups. Thus, in this study, eszopiclone did not improve sleep sufficiently to improve fatigue in MS patients. This result may be due to the multifactorial nature of sleep disturbances and fatigue in people with MS.
The Role of Postpartum Intravenous Corticosteroids in the Prevention of Relapses in Multiple Sclerosis
Authors: Avila-Ornelas Jose , Avila Mirla , Stosic Milena , Robles Liliana , Prieto Pilar Guillermo , Hutton George J. , Rivera Victor M.
Published: April 2012

Multiple sclerosis (MS) is most prevalent in women of childbearing age. It is well established that the relapse rate decreases during pregnancy but increases significantly during the first postpartum trimester. The objective of this retrospective study was to evaluate the effectiveness of the administration of 1 g of intravenous methylprednisolone (IVMP) after delivery in the prevention of MS relapses. The study involved 47 women with one or more documented pregnancies; each pregnancy was treated as a separate case. There were 50 cases with relapsing-remitting MS and 2 with secondary progressive MS. The cases were divided into two groups: the IVMP group (those who received 1 g of IVMP after delivery) and the no-IVMP group (those who did not receive IVMP after delivery). There were 39 cases in the IVMP group and 13 in the no-IVMP group. During the first postpartum trimester, relapses occurred in 17.9% of the IVMP group, compared with 46.2% of the no-IVMP group (P = .0448). The difference in relapse percentage between the two groups during the second and third postpartum trimesters was not statistically significant. Our study shows a statistically significant benefit of postpartum IVMP administration in reducing MS relapses.
Validation of the NARCOMS Registry
Authors: Marrie Ruth Ann , Goldman Myla
Published: April 2012

Tremor secondary to multiple sclerosis (MS) can be severely disabling but remains understudied. The development of brief, acceptable patient-reported measures of tremor could facilitate further study. We aimed to assess the criterion and construct validity of the Tremor and Coordination Scale (TACS) used by the North American Research Committee on Multiple Sclerosis (NARCOMS) Registry. Forty-four patients with MS completed the TACS and Performance Scales and underwent a neurologic examination (Expanded Disability Status Scale; EDSS) and evaluation with the Multiple Sclerosis Functional Composite (MSFC). We assessed criterion and construct validity with Spearman rank correlations between the TACS and the following measures: EDSS, Nine-Hole Peg Test (NHPT) of the MSFC, age, body-mass index (BMI), the hand function and mobility domains of the Performance Scales, and the Physical and Mental Composite Scores of the 36-item Short Form Health Status Survey (SF-36). The median (interquartile range; IQR) score on the TACS was 1 (0.5–2.0). The TACS correlated moderately with the cerebellar Functional System Score (FSS) (r = 0.51; 95% confidence interval [CI], 0.24–0.70) and with the NHPT (r = −0.51; 95% CI, −0.70 to −0.29). The TACS correlated with the hand (r = 0.60; 95% CI, 0.36–0.76) and mobility (r = 0.56; 95% CI, 0.31–0.73) domains of the Performance Scales. The TACS did not correlate significantly with age (r = −0.11; 95% CI, −0.40 to 0.19) or BMI (r = 0.15; 95% CI, −0.15 to 0.43). These findings support the criterion and construct validity of the TACS. Further evaluation is needed to establish the test-retest reliability of the scale and its responsiveness to change.
Developing a Wellness Program for People with Multiple Sclerosis
Authors: Hart Dennis L. , Memoli Ruth I. , Mason Brian , Werneke Mark W.
Published: April 2012

Because multiple sclerosis (MS) is a multidimensional chronic disease, effective management of the illness requires a multidimensional approach. We describe a wellness program that was designed to facilitate positive health choices throughout the course of MS and present initial data analyses. We hypothesized that over the course of the program, participants would demonstrate improvement in the domains assessed. The wellness program included educational sessions in physical, mental, social, intellectual, and spiritual domains specifically targeting improved self-efficacy, physical functioning, coping skills, symptom management, and nutrition. An outcomes data collection software program was adapted to facilitate real-time patient self-report and clinician entry data collection for many domains throughout the wellness program. Initial assessment of serial measures (intake to discharge) from 65 people with MS showed improvement in several domains, including functional status (P < .05), fatigue (P < .05), fear-avoidance beliefs regarding physical activities (P < .05), depression (P < .05), somatization (P < .05), and pain (P < .05). In addition, using a model of risk for interpersonal distress, patients whose risk of elevated depression and anxiety decreased over the course of the program reported greater gains in functional status (P < .05). The results suggest possible future treatment strategies and indicate strengths and weaknesses of the wellness program, which are being used to improve the program.
Adherence to First-Line Disease-Modifying Therapy for Multiple Sclerosis in Kuwait
Authors: Alroughani Raed , Thussu Anil
Published: April 2012

The aim of this retrospective study was to determine the rate of nonadherence to disease-modifying therapies (DMTs) among multiple sclerosis (MS) patients in Kuwait and to identify reasons for patient discontinuation of long-term therapy. Using a newly established MS registry at our institution, we collected data on MS patients' demographics, clinical characteristics, disability measures, and continuation or discontinuation of first-line DMTs. Reasons for nonadherence were divided into four categories: adverse events, inconvenience, perceived lack of efficacy, and physician-documented disease progression. Of 212 eligible patients, 40.1% were found to be nonadherent to first-line DMTs. In the nonadherent group, the female-to-male ratio was 1.75:1 and the mean age at disease onset was 26.8 years. Of this group, 69.4% of patients had a relapsing-remitting course, 18.8% had a secondary progressive course, and 11.8% had clinically isolated syndrome. Compared with the adherent group, the nonadherent group had a shorter mean disease duration (P = .014) and a greater likelihood of having Expanded Disability Status Scale (EDSS) scores of 3 or lower (67.1% vs. 48.0%; P = .007). Inconvenience was the most common reason for nonadherence (32.9%), followed by perceived lack of efficacy (25.9%), adverse events (23.5%), and physician-documented disease progression (17.7%). In summary, the rate of nonadherence to first-line DMTs in MS patients at our institution is considered high. Most nonadherent patients had a short disease duration and low EDSS scores. Inconvenience and perceived lack of efficacy were the most common reasons for nonadherence. The results demonstrate a need to improve treatment adherence among MS patients in Kuwait through providing better patient education, improving communication between patients and health-care providers, defining therapy expectations, and instituting new therapeutic techniques.
Availability of Medications for Opioid Use Disorder in Community Mental Health Facilities
Authors: Cantor Jonathan , Griffin Beth Ann , Levitan Barbara , Mendon-Plasek Sapna J. , Stein Bradley D. , Hunter Sarah B. , Ober Allison J.
Published: June 2024

Importance

Medications for opioid use disorder (MOUD) are an effective but underutilized treatment. Opioid use disorder prevalence is high among people receiving treatment in community outpatient mental health treatment facilities (MHTFs), but MHTFs are understudied as an MOUD access point.

Objective

To quantify availability of MOUD at community outpatient MHTFs in high-burden states as well as characteristics associated with offering MOUD.

Design, Setting, and Participants

This cross-sectional study performed a phone survey between April and July 2023 among a representative sample of community outpatient MHTFs within 20 states most affected by the opioid crisis, including all Certified Community Behavioral Health Centers (CCBHCs). Participants were staff at 450 surveyed community outpatient MHTFs in 20 states in the US.

Main Outcomes and Measures

MOUD availability. A multivariable logistic regression was fit to assess associations of facility, county, and state-level characteristics with offering MOUD.

Results

Surveys with staff from 450 community outpatient MHTFs (152 CCBHCs and 298 non-CCBHCs) in 20 states were analyzed. Weighted estimates found that 34% (95% CI, 29%-39%) of MHTFs offered MOUD in these states. Facility-level factors associated with increased odds of offering MOUD were: self-reporting being a CCBHC (odds ratio [OR], 2.11 [95% CI, 1.08-4.11]), providing integrated mental and substance use disorder treatment (OR, 5.21 [95% CI, 2.44-11.14), having a specialized treatment program for clients with co-occurring mental and substance use disorders (OR, 2.25 [95% CI, 1.14-4.43), offering housing services (OR, 2.54 [95% CI, 1.43-4.51]), and laboratory testing (OR, 2.15 [95% CI, 1.12-4.12]). Facilities that accepted state-financed health insurance plans other than Medicaid as a form of payment had increased odds of offering MOUD (OR, 1.95 [95% CI, 1.01-3.76]) and facilities that accepted state mental health agency funds had reduced odds (OR, 0.43 [95% CI, 0.19-0.99]).

Conclusions and Relevance

In this study of 450 community outpatient MHTFs in 20 high-burden states, approximately one-third offered MOUD. These results suggest that further study is needed to report MOUD uptake, either through increased prescribing at all clinics or through effective referral models.
Diet predisposes to pancreatic cancer through cellular nutrient sensing pathways
Authors: Noè Roberta , Carrer Alessandro
Published: June 2024

Pancreatic cancer is a lethal disease with limited effective treatments. A deeper understanding of its molecular mechanisms is crucial to reduce incidence and mortality. Epidemiological evidence suggests a link between diet and disease risk, though dietary recommendations for at‐risk individuals remain debated. Here, we propose that cell‐intrinsic nutrient sensing pathways respond to specific diet‐derived cues to facilitate oncogenic transformation of pancreatic epithelial cells. This review explores how diet influences pancreatic cancer predisposition through nutrient sensing and downstream consequences for (pre‐)cancer cell biology. We also examine experimental evidence connecting specific food intake to pancreatic cancer progression, highlighting nutrient sensing as a promising target for therapeutic development to mitigate disease risk.
Developing and operating unit‐type green parklets for parking lots in urban area—Part 1: Development and experimental study of unit‐type green parklets
Authors: Takata Masahito
Published: June 2024

Aiming to improve thermal environment for outdoor public spaces, the author had been developing a unit‐type green parklet for parking lots that both introduce greenery into cities and produce walkable urban spaces. In this study, the author examined and created a full‐size unit‐type green parklet, installed it in a parking lot adjacent to sidewalk space next to a bus stop in the traditional urban area, Kyomachi district, of Kumamoto City, and investigated the improvement to summer thermal environment from a field measurement and its usage by people from user survey in summer (from August 30 to September 5, 2022). The results showed that although the parklet shaded with the parasol and greening units, air temperature dropped by only a maximum of 1°C in daytime. Given the characteristics of parking lot as a location, it was confirmed that not only the wind and airflow conditions was blocked and worsened, but reflected solar radiation from the surroundings and generated heat from parked cars degraded air temperature and MRT from the field measurement. Furthermore, it was confirmed to be ensured the visibility of the surroundings when sitting on the parklet bench for the users waiting for a bus from user survey.
Treatment plan complexity quantification for predicting gamma passing rates in patient‐specific quality assurance for stereotactic volumetric modulated arc therapy
Authors: Xue Xudong , Luan Shunyao , Ding Yi , Li Xiangbin , Li Dan , Wang Jingya , Ma Chi , Jiang Man , Wei Wei , Wang Xiao
Published: June 2024

Purpose

To investigate the beam complexity of stereotactic Volumetric Modulated Arc Therapy (VMAT) plans quantitively and predict gamma passing rates (GPRs) using machine learning.

Methods

The entire dataset is exclusively made of stereotactic VMAT plans (301 plans with 594 beams) from Varian Edge LINAC. The GPRs were analyzed using Varian's portal dosimetry with 2%/2 mm criteria. A total of 27 metrics were calculated to investigate the correlation between metrics and GPRs. Random forest and gradient boosting models were developed and trained to predict the GPRs based on the extracted complexity features. The threshold values of complexity metric were obtained to predict a given beam to pass or fail from ROC curve analysis.

Results

The three moderately significant values of Spearman's rank correlation to GPRs were 0.508 (p < 0.001), 0.445 (p < 0.001), and −0.416 (p < 0.001) for proposed metric LAAM, the ratio of the average aperture area over jaw area (AAJA) and index of modulation, respectively. The random forest method achieved 98.74% prediction accuracy with mean absolute error of 1.23% using five‐fold cross‐validation, and 98.71% with 1.25% for gradient boosting regressor method, respectively. LAAM, leaf travelling distance (LT), AAJA, LT modulation complexity score (LTMCS) and index of modulation, were the top five most important complexity features. The LAAM metric showed the best performance with AUC value of 0.801, and threshold value of 0.365.

Conclusions

The calculated metrics were effective in quantifying the complexity of stereotactic VMAT plans. We have demonstrated that the GPRs could be accurately predicted using machine learning methods based on extracted complexity metrics. The quantification of complexity and machine learning methods have the potential to improve stereotactic treatment planning and identify the failure of QA results promptly.
Transformation of Natural Resin Resina Draconis to 3D Functionalized Fibrous Scaffolds for Efficient Chronic Wound Healing
Authors: Guo Shijie , Wang Pengyu , Sun Yu , Cao Can , Gao Junwei , Hong Shihao , Li Ning , Xu Ruodan
Published: June 2024

Chronic wound healing is a major challenge in clinical practice. Secondary dressing damage and antibiotic resistance are the main obstacles for traditional wound dressings. Resina draconis (RD), a natural resin traditionally used in powder form for wound care, is now considered unsuitable due to the lack of gas permeability and moist environment required for wound healing. Here, RD is incorporated in situ by constructing a 3D coiled fibrous scaffold with polycaprolactone/polyethylene oxide. Due to the high porosity of 3D scaffold, the RD‐3D dressings have a favorable swelling capacity, providing permeability and moisture for wound repair. Meanwhile, the transformation of RD powder into 3D dressings fully demonstrates capabilities of RD in rapid hemostasis, bactericidal, and inflammation‐regulating activities. In vivo evaluations using pressure ulcer and infected wound models confirm the high efficacy of RD‐3D dressing in early wound healing, particularly beneficial in the infected wound model compared to recombinant bovine FGF‐basic. Further biological analysis shows that resveratrol, loureirin A, and loureirin B, as potentially bioactive components of RD, individually contribute to different aspects of wound healing. Collectively, RD‐3D integrated dressings represent a simple, cost‐effective, and safe approach to wound healing, providing an alternative therapy for translating medical dressings from bench to bedside.
Modeling, Parameters and Synaptic Plasticity Analysis of Lateral‐Ionic‐Gated Graphene Synaptic FETs
Authors: He Xiaoying , Cao Bowen , Xu Minghao , Wang Kun , Rao Lan
Published: June 2024

Exploiting simulation modeling of graphene synaptic field‐effect transistors is extremely important for helping researchers to construct carbon‐based neuromorphic computing systems. Here, lateral‐ionic‐gated graphene synaptic FETs with different gate lengths are fabricated, and they are modeled by using basic physic models combined with the ions migration‐diffusion model and graphene material model. The feasibility and accuracy of the proposed modeling are validated by showing an excellent agreement between simulations and experimental results. The slicing technique of the modeling is proposed to analyze the influence of ionic concentration and diffusion coefficient on the ions movement to reveal their working mechanism. The effect of key parameters about gate length, ionic concentration, and diffusion coefficient on synaptic behavior such as short‐term plasticity, and long‐term plasticity is simulated and discussed. In addition, three kinds of spike‐timing‐dependent plasticity are obtained by the device modeling. This research opens up promising avenues for the development of artificial synapse modeling and paths to new opportunities for the construction of carbon‐based neuromorphic networks.
Phosphonate Diacid Molecule Induced Crystallization Manipulation and Defect Passivation for High‐Performance Inverted MA‐Free Perovskite Solar Cells
Authors: Wang Ke , Xu Zhiyuan , Guo Zhihao , Wang Huaxin , Qaid Saif M. H. , Yang Ke , Zang Zhigang
Published: June 2024

Inverted perovskite solar cells (PSCs) comprising formamidinium‐cesium (FA‐Cs) lead triiodide have garnered considerable attention due to their impressive efficiency and remarkable stability. Nevertheless, synthesizing high‐quality FA‐Cs alloyed perovskite films presents challenges, primarily attributable to the intricate interphase process involved and the absence of methylammonium (MA+) and mixed halogens. Here, the additive 3‐phosphonopropanoic acid (3‐PPA) is introduced, with bifunctional phosphonic acid groups, into the perovskite precursor to modulate the crystal growth and provide passivation at grain boundaries. In situ characterization reveals that the 3‐PPA can form a “rapid nucleation, slow growth” mechanism, resulting in perovskite films with enlarged grains and enhanced crystallinity. In addition, 3‐PPA serves to passivate grain boundary defects and release residual strain by forming molecular bridging, leading to the passivated films achieving a fluorescence lifetime of 5.79 microseconds with a favorable n‐type contact interface. As a result, the resulting devices incorporating 3‐PPA achieve a champion power conversion efficiency (PCE) of 24.05% and an ultra‐high fill factor (FF) of 84.22%. More importantly, the optimized devices exhibit satisfactory stability under various testing conditions. The findings underscore the pivotal role of multifunctional additives in crystallization control and defect passivation for high‐performance MA‐free and pure iodine PSCs.
Incidence, mortality, survival, and treatment statistics of cancers in digestive organs—Japanese cancer statistics 2024
Authors: Higashi Takahiro , Kurokawa Yukinori
Published: June 2024

Access to accurate statistical data is paramount in the pursuit of effective cancer control activities, including research, policy development, and clinical care. This paper presents a comprehensive statistical report on the incidence, mortality, survival, and treatment of major digestive organ cancers, including those of the esophagus, stomach, colon, rectum, liver, extrahepatic biliary tract, and pancreas, in Japan. We compiled data from the National Cancer Center's “Cancer Information Services” and government “e‐Stat” websites and offered a succinct overview of basic statistics by using tables and graphical presentations. Our findings underscore the critical role of the National Cancer Registry introduced by the Cancer Registry Act of 2016, which mandates hospitals across Japan to report cancer cases. This system ensures more accurate incidence statistics. Mortality data sourced from the National Vital Statistics System and survival rates derived from hospital‐based cancer registries offer insights into the outcomes and efficacy of treatment modalities. These data indicate a downward trend in mortality for stomach and liver cancers and stable or declining rates for other cancers except pancreatic cancer, which has the lowest survival rate. Treatment patterns indicate an increase in endoscopic procedures for esophageal and stomach cancers, with stable treatment approaches for colorectal cancer. This statistical overview aims to improve the understanding and inform research, policy, and clinical decisions in the field of digestive organ cancers.
Delayed diagnosis in a child with strangulated mesenteric hernia
Authors: Tetsuhara Kenichi , Nakabayashi Kazunobu , Muraoka Mamoru , Kikuno Rie , Ueda Michiko , Inoue Ryo , Hayashida Makoto
Published: June 2024

Background

Strangulated intestinal obstruction is a life‐threatening condition that should be considered as a differential diagnosis in children with shock. However, it has pitfalls in diagnosis and can lead to diagnostic errors.

Case Presentation

A 3‐month‐old male patient presented with a pale complexion lasting 2 h and abnormal crying. He was in shock with lactic acidosis, altered mental status, and slight abdominal distension. He required volume resuscitation, vasoactive agents, and transfusion. On Day 2, he had marked abdominal distension and acute kidney injury, which required continuous kidney replacement therapy. Contrast‐enhanced computed tomography revealed extensive intestinal ischemia. It took 33.5 h from his arrival to the computed tomography, leading to operative management. The small intestine had entered a mesenteric hiatus, leading to ischemia. He was diagnosed with strangulated mesenteric hernia.

Conclusion

In this case, four pitfalls led to delayed diagnosis. Factors for diagnostic errors specific to strangulated intestinal obstruction and intensive care should be noted.
The Use of Photocycloaddition Reactions to Drive Mechanical Motions Resembling Humanoid Movements
Authors: Wang Yong , Zhang Qiaoqiao , Liu Qi , Abrahams Brendan F. , Lang Jian‐Ping
Published: June 2024

With the aim of producing a photomechanical material for incorporation in soft microrobots, a one‐dimensional diene coordination polymer (CP) [Cd(F‐bpeb)(3‐CBA)2]n (CP1, F‐bpeb=4,4′‐((1E,1′E)‐(2,5‐difluoro‐1,4‐phenylene)bis(ethene‐2,1‐diyl))dipyridine, 3‐HCBA=3‐chlorobenzoic acid) was synthesized and characterized. Irradiation of CP1 with ultraviolet (UV) or visible light causes [2+2] photocycloaddition reactions resulting in the introduction of crystal strain which triggers various types of crystal movements. Composite films of CP1‐PVA (SC) fabricated by dispersing CP1 crystals into polyvinyl alcohol (PVA) solution allow amplification of the crystal movement so that the film strips exhibit fast and flexible curling upon photoirradiation. The composite films may be cut into long rectangular strips and folded to simulate soft microrobots which exhibit a variety of fast, flexible and continuous photomechanical movements resembling a human performing various gymnastic exercises.
Cover Picture: Astron. Nachr. 6/2024
Authors: Scalco Michele , Gerasimov Roman , Bedin Luigi R. , Vesperini Enrico , Nardiello Domenico , Salaris Maurizio , Burgasser Adam , Anderson Jay , Libralato Mattia , Bellini Andrea , Rosati Piero
Published: June 2024

Color‐magnitude diagram of the lower mass end of the Main Sequence of globular cluster NGC 6752, as derived from NIR images of a deep field observed under a HST Large Programme led by L.R.Bedin. Three main stellar populations can be reliably distinguished within this cluster. The three isochrones (blue, green, and red lines) were computed with different chemical compositions, adjusted to match the observed colors of the different generations of stars at an age of 12.63 Gy. In the lower left part of the plot, the corresponding isochrone for the White Dwarfs (at an age of 12.5 Gy) is shown in purple, together with the three WD candidates shown as orange crosses. For each isochrone, specific mass values are marked by labeled filled dots. A detailed analysis of the HST data and a discussion of possible scenarios for the formation of multiple stellar populations within NGC 6752 is presented in the article by Scalco et al., this issue e240018.

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Partial privatisation and green innovation in China: The role of industrial context and regional development
Authors: Usman Muhammad , Ishaque Maria , Gull Ammar Ali , Tawiah Vincent
Published: June 2024

This study examines the relationship between partial privatisation (i.e., state ownership reduction) and green innovation in China. Employing a large dataset of 36,072 firm‐year observations between 2005 and 2022, we document a positively significant association between partial privatisation and green innovation, suggesting that privatisation promotes green innovation in Chinese firms. Further analyses shows that the relationship is stronger for firms in environmentally sensitive industries and those located in more developed regions. Our main finding is robust to the alternative measurement of variables and endogeneity concerns using the propensity score matching (PSM), firm‐fixed effects and the system generalised method of moments (GMM) approach. Finally, we document that green innovation in privatised firms yields superior performance. Our findings highlight the significant contribution of privatisation in the quest for low‐carbon emissions in China by promoting green innovation.
Positive, negative or graded sustainability labelling? Which is most effective at promoting a shift towards more sustainable product choices?
Authors: Thøgersen John , Dessart François J. , Marandola Ginevra , Hille Stefanie Lena
Published: June 2024

Sustainability labels convey information about different product attributes, such as its environmental impact, lifespan or ethical performance. The labelling can be either positive (only identifying the most sustainable products available on the market), negative (only identifying the least sustainable products available on the market) or graded (comparing the sustainable performance of a product with that of all other products on the market). We assess the relative performance of these three labelling approaches in terms of influencing product choices. A nationally representative sample of 1243 consumers from Germany, Spain and the Czech Republic participated in an incentive‐compatible online discrete choice experiment with random allocation to different labelling approaches. Compared with positive and negative labels, graded labels were most effective in guiding consumers towards more sustainable product choices. These findings support policy interventions that convey product sustainability with graded labels.
The development of an automated microscope image tracking and analysis system
Authors: McAfee Lillian , Heath Zach , Anderson William , Hozi Marvin , Orr John Walker , Kang Youngbok (Abraham)
Published: June 2024

Microscopy image analysis plays a crucial role in understanding cellular behavior and uncovering important insights in various biological and medical research domains. Tracking cells within the time‐lapse microscopy images is a fundamental technique that enables the study of cell dynamics, interactions, and migration. While manual cell tracking is possible, it is time‐consuming and prone to subjective biases that impact results. In order to solve this issue, we sought to create an automated software solution, named cell analyzer, which is able to track cells within microscopy images with minimal input required from the user. The program of cell analyzer was written in Python utilizing the open source computer vision (OpenCV) library and featured a graphical user interface that makes it easy for users to access. The functions of all codes were verified through closeness, area, centroid, contrast, variance, and cell tracking test. Cell analyzer primarily utilizes image preprocessing and edge detection techniques to isolate cell boundaries for detection and analysis. It uniquely recorded the area, displacement, speed, size, and direction of detected cell objects and visualized the data collected automatically for fast analysis. Our cell analyzer provides an easy‐to‐use tool through a graphical user interface for tracking cell motion and analyzing quantitative cell images.
Evaluation of TrpM and PsiD substrate promiscuity reveals new biocatalytic capabilities
Authors: Kanis Fiona C. , Broude Caroline N. , Hellwarth Elle B. , Gibbons William J. , Sen Abhishek K. , Adams Alexandra M. , Wang Xin , Jones J. Andrew
Published: June 2024

N‐methylated tryptamines, such as the hallucinogenic natural products, psilocybin and N,N‐dimethyltryptamine (DMT), are gaining interest from the medical community due to their potential as next generation treatments for mental health disorders. The clinical relevance of these compounds has driven scientists to develop biosynthetic production routes to a number of tryptamine drug candidates, and efforts are ongoing to expand and further develop these biosynthetic capabilities. To that end, we have further characterized the substrate preferences of two enzymes involved in tryptamine biosynthesis: TrpM, a tryptophan N‐methyltransferase from Psilocybe serbica, and PsiD, the gateway decarboxylase of the psilocybin biosynthesis pathway. Here, we show that TrpM can N‐methylate the non‐native amino acid substrate, 4‐hydroxytryptophan, a key intermediate in the Escherichia coli‐based recombinant psilocybin biosynthesis pathway. However, the ability to incorporate TrpM into a functional psilocybin biosynthesis pathway was thwarted by PsiD's inability to use N,N‐dimethyl‐4‐hydroxytryptophan as substrate, under the culturing conditions tested, despite demonstrating activity on N‐methylated and 4‐hydroxylated tryptophan derivatives individually. Taken together, this work expands upon the known substrates for TrpM and PsiD, further increasing the diversity of tryptamine biosynthetic products.
Prognostic impact of elective tracheotomy in resected oral cavity squamous cell carcinoma: A nationwide cohort study
Authors: Fang Ku‐Hao , Kang Chung‐Jan , Lee Li‐Yu , Ng Shu‐Hang , Lin Chien‐Yu , Chen Wen‐Cheng , Lin Jin‐Ching , Tsai Yao‐Te , Lee Shu‐Ru , Chien Chih‐Yen , Hua Chun‐Hung , Wang Cheng Ping , Chen Tsung‐Ming , Terng Shyuang‐Der , Tsai Chi‐Ying , Wang Hung‐Ming , Hsieh Chia‐Hsun , Fan Kang‐Hsing , Yeh Chih‐Hua , Lin Chih‐Hung , Tsao Chung‐Kan , Cheng Nai‐Ming , Fang Tuan‐Jen , Huang Shiang‐Fu , Lee Li‐Ang , Wang Yu‐Chien , Lin Wan‐Ni , Hsin Li‐Jen , Yen Tzu‐Chen , Wen Yu‐Wen , Liao Chun‐Ta
Published: June 2024

Background

Elective tracheotomy is commonly performed in resected oral squamous cell carcinoma (OCSCC) to maintain airway patency. However, the indications for this procedure vary among surgeons. This nationwide study evaluated the impact of tracheotomy on both the duration of in‐hospital stay and long‐term survival outcomes in patients with OCSCC.

Methods

A total of 18,416 patients with OCSCC were included in the analysis, comprising 7981 patients who underwent elective tracheotomy and 10,435 who did not. The primary outcomes assessed were 5‐year disease‐specific survival (DSS) and overall survival (OS). To minimize potential confounding factors, a propensity score (PS)‐matched analysis was performed on 4301 patients from each group. The duration of hospital stay was not included as a variable in the PS‐matched analysis.

Results

Prior to PS matching, patients with tracheotomy had significantly lower 5‐year DSS and OS rates compared to those without (71% vs. 82%, p < 0.0001; 62% vs. 75%, p < 0.0001, respectively). Multivariable analysis identified tracheotomy as an independent adverse prognostic factor for 5‐year DSS (hazard ratio = 1.10 [1.03–1.18], p = 0.0063) and OS (hazard ratio = 1.10 [1.04–1.17], p = 0.0015). In the PS‐matched cohort, the 5‐year DSS was 75% for patients with tracheotomy and 76% for those without (p = 0.1488). Five‐year OS rates were 66% and 67%, respectively (p = 0.0808). Prior to PS matching, patients with tracheotomy had a significantly longer mean hospital stay compared to those without (23.37 ± 10.56 days vs. 14.19 ± 8.34 days; p < 0.0001). Following PS matching, the difference in hospital stay duration between the two groups remained significant (22.34 ± 10.25 days vs. 17.59 ± 9.54 days; p < 0.0001).

Conclusions

While elective tracheotomy in resected OCSCC patients may not significantly affect survival, it could be associated with prolonged hospital stays.
Who will stay and who will go? Identifying risk factors for psychotherapy dropout
Authors: McGovern Christopher , Athey Alison , Beale Eleanor E. , Overholser James C. , Gomez Stephanie H. , Silva Christiana
Published: June 2024

Objective

Dropout from psychotherapy remains an issue across various treatment modalities and psychological disorders, with roughly 20% of clients failing to complete treatment. Dropping out of psychotherapy is associated with worse psychological and physical health outcomes. This study aimed to use a clinically generalisable definition of dropout to identify risk factors for dropping out of psychotherapy.

Method

Retrospective chart review methods were used to collect data on 203 clients seen at a community‐based clinical psychology doctoral training clinic.

Results

Independent samples t‐tests and chi‐squared tests for independence indicated that clients who dropped out of psychotherapy were more likely to be non‐students, live farther away from the treatment clinic and no‐show at least once in the first four sessions of therapy.

Discussion

To address dropout risk, it is important that clinicians be attuned to possible indicators of structural and motivational barriers to treatment engagement.
Structure–performance relationship of Au nanoclusters in electrocatalysis: Metal core and ligand structure
Authors: Li Bowen , Kang Lianmei , Lun Yongfeng , Yu Jinli , Song Shuqin , Wang Yi
Published: June 2024

Remarkable progress has characterized the field of electrocatalysis in recent decades, driven in part by an enhanced comprehension of catalyst structures and mechanisms at the nanoscale. Atomically precise metal nanoclusters, serving as exemplary models, significantly expand the range of accessible structures through diverse cores and ligands, creating an exceptional platform for the investigation of catalytic reactions. Notably, ligand‐protected Au nanoclusters (NCs) with precisely defined core numbers offer a distinct advantage in elucidating the correlation between their specific structures and the reaction mechanisms in electrocatalysis. The strategic modulation of the fine microstructures of Au NCs presents crucial opportunities for tailoring their electrocatalytic performance across various reactions. This review delves into the profound structural effects of Au NC cores and ligands in electrocatalysis, elucidating their underlying mechanisms. A detailed exploration of the fundamentals of Au NCs, considering core and ligand structures, follows. Subsequently, the interaction between the core and ligand structures of Au NCs and their impact on electrocatalytic performance in diverse reactions are examined. Concluding the discourse, challenges and personal prospects are presented to guide the rational design of efficient electrocatalysts and advance electrocatalytic reactions.
Enhancing the efficiency of two‐stage cyclones without increasing pressure drop by optimizing inlet and outlet dimensions
Authors: He Jiongjie , Zhu Zhenxing , Niu Hongbin , Tian Zhihong , Yang Jingxuan , Sun Guogang
Published: June 2024

Efforts to enhance cyclone separators aim to minimize gas energy consumption while improving separation efficiency. This study attempts to achieve this goal for cyclones arranged in series using straightforward methods. Experimental and numerical simulation analyses were performed to study the effect of matching inlet and outlet diameters on the performance of a two‐stage tandem cyclone separator. The results show that the matching method, in which the inlet gas velocities of both stages are higher than the outlet gas velocity, has a better separation efficiency. The efficiency and pressure drop models of the two‐stage cyclones in series were constructed using the response surface methodology (RSM) to obtain the optimal combination of inlet size and exhaust pipe diameter. Experimental tests showed that the accuracy of this model was reasonable. At different permitted pressure drops, the optimized structure revealed that: (1) The inlet area should be smaller than the outlet area for each cyclone stage. (2) The secondary inlet size (KA) should be as large as possible. (3) dr decreases while KA increases in each step.