bluuebunny/crossref_metadata_2025 huggingface dataset:
Ultrasound: Impact on Diagnostic Peritoneal Lavage, Abdominal Computed Tomography, and Resident Training
Authors: Davis J. Russell , Morrison Ashley L. , Perkins Samuel E. , Davis Frank E. , Ochsner M. Gage
Published: November 2022

Our objective was to determine the impact of abdominal ultrasound (US) on 1) the use of diagnostic peritoneal lavage (DPL) and abdominal computed tomography (ACT) for diagnosing blunt abdominal trauma (BAT) and on 2) surgical resident training. The study design was a retrospective chart review. Patients sustaining BAT who had ACT or DPL done during the 1-year period before the introduction of US (pre-US) were compared with those from a 1-year period beginning 6 months after US (post-US). Data collected included diagnostic modality, demographic data, mortality, associated injuries, length of stay, mechanism of injury, and number of exploratory laparotomies. Of 128 patients in the pre-US group, 35 patients (27%; P < 0.001) underwent DPL, 0 patients (0%; P < 0.001) received US, and 92 patients (72%) received ACT, with positive results for 31 patients (34%). Exploratory laparotomy was performed on 35 patients (27%) in the pre-US group. Of 140 patients in the post-US group, 8 patients (6%; P < 0.001) underwent DPL, 120 patients (85%; P < 0.001) received US, and 108 patients (77%) received ACT, with positive results for 44 patients (42%). Exploratory laparotomy was performed on 22 patients (15%; P < 0.001) in the post-US group. Resident experience with DPL before and after the introduction of US and availability of US for graduated residents was documented. Chi-square and Fisher's exact test were used for statistical analysis. Resident experience changed from 22 to 3 DPLs per year in the pre- and post-US groups, respectively. Ten per cent of graduating residents had US available for use after leaving this institution. US replaced DPL and resulted in slightly more positive ACT scans in assessing BAT at our institution. Paradoxically, only 10 per cent of graduating residents had US available after leaving this institution. Until the use of US for diagnosing BAT has widespread use in the community, we must question our adequacy of resident preparation for diagnosing BAT.
Giant Colonic Diverticulum: Report of a Case
Authors: Havenstrite Keith A. , Harris James A. , Rivera David E.
Published: November 2022

Giant colonic diverticulum is a rare complication of colonic diverticulosis. It typically occurs as a single diverticulum located on the antimesenteric border of the sigmoid colon. The most widely accepted theory for its development attributes the progressive dilation to a “ball-valve” mechanism, allowing air to enter but not to exit. Patients usually present complaining of abdominal pain and/or an abdominal mass, although they may remain asymptomatic. Physical examination reveals a tympanic abdominal mass that appears as a round radiolucency on plain radiographs and CT. Barium enema demonstrates the relationship of the diverticulum to bowel and may document communication with the colonic lumen. To alleviate symptoms and prevent complications, the recommended treatment is excision of the diverticulum in continuity with the involved colonic segment. We report a case and discuss the presentation, diagnosis, and management of giant colonic diverticulum.
Peripheral Clear Cell Cholangiocarcinoma: A Rare Histologic Variant
Authors: Falta Edward M. , Rubin Allen D. , Harris James A.
Published: November 2022

We present the case of a 50-year-old diabetic male who underwent open cholecystectomy for acute gangrenous cholecystitis. At the time of exploration, a 1.5-cm mass was found peripherally in the right lobe of his liver, and an incisional biopsy was performed. Microscopic examination revealed a distinct overgrowth of clear cells in an acinar pattern, with tumor cells emerging directly from bile ducts. The tumor cells were periodic acid-Schiff reactive and diastase resistant, indicating the presence of mucin. No bile canaliculi were demonstrated by immunostaining with carcinoembryonic antigen. CT scans of the chest and abdomen were otherwise normal. Based on these microscopic, immunohistochemical, and clinical data, a diagnosis of clear cell cholangiocarcinoma was established. The patient later underwent reexploration and generous hepatic wedge resection. He did well postoperatively and is free of disease after 12 months.
The Effect of Lexipafant on Bacterial Translocation in Acute Necrotizing Pancreatitis in Rats
Authors: Liu Qiang , Djuricin Goldie , Rossi Heather , Bewsey Kelly , Nathan Catherine , Gattuso Paolo , Weinstein Robert A. , Prinz Richard A.
Published: November 2022

Bacterial translocation (BT) from the gastrointestinal tract to mesenteric lymph nodes (MLNs) and other extra intestinal organs is an important source of infection in acute pancreatitis (AP). Lexipafant (BB-882) is a potent platelet-activating factor receptor antagonist that has an anti-inflammatory effect. To examine whether BB-882 could affect BT in acute necrotizing pancreatitis, 48 male Sprague Dawley rats (250–350 g) were studied. AP was induced in Group I and Group II by pressure injection of 3% taurocholate and trypsin into the common biliopancreatic duct (1 mL/kg of body weight). Group I rats received BB-882 (10 mg/kg, ip qd) and Group II rats received a similar volume of normal saline as a placebo postoperatively for 2 days. Group III and Group IV received BB-882 and placebo, respectively, after an exploratory laparotomy. At 48 hours postoperatively, blood was drawn for culture, serum amylase, and tumor necrosis factor (TNF)-α determinations. Specimens from MLNs, spleen, liver, pancreas, and cecum were harvested for culture of Gram-positive, Gram-negative, and anaerobic bacteria. Quantitative cecal cultures of Gram-positive, Gram-negative, and anaerobic bacteria were obtained. A point scoring system for five histological features that include interstitial edema, inflammatory cellular infiltration, fat necrosis, parenchymal necrosis, and hemorrhage was used to evaluate the severity of pancreatitis. There was no difference in serum amylase levels (2415 ± 127 IU/L versus 2476 ± 170 IU/L), serum TNF-α levels (7820 ± 1396 pg/mL versus 7318 ± 681 pg/mL), and the mean pancreatic histology score (5.9 ± 1.2 versus 6.5 ± 1.1) between Group I and Group II, respectively (P gt 0.05). Seven of 12 Group I rats had BT to MLNs, compared with 11 of 12 rats in Group II (P > 0.05). Five of 12 Group I rats had BT to distant sites such as pancreas, spleen, liver, and/or blood, compared with 11 of 12 rats in Group II (P < 0.05). BB-882 treatment decreases bacterial spread to distant sites, but does not reduce serum amylase levels and serum TNF-α levels or ameliorate pancreatic damage in rats with AP.
Follow-Up Evaluation and Clinical Course of Patients with Benign Nodular Thyroid Disease
Authors: Mittendorf Elizabeth A. , Mchenry Christopher R.
Published: November 2022

Reliance on fine-needle aspiration biopsy (FNAB) in determining which patients with a thyroid nodule can be observed depends on a low false-negative rate. The purpose of this study was to determine the false-negative rate of FNAB, the utility of routine repeat FNAB, and the clinical course of patients with benign nodular thyroid disease. The records of all patients with nodular thyroid disease evaluated between June 1990 and May 1998 were reviewed. Patients with a benign FNAB were identified, and nodule size, substernal extension, the results of repeat FNAB, clinical course, histologic diagnosis, and length of follow-up were determined. Of the 341 patients referred with nodular thyroid disease, 121 had a benign FNAB. In 80 patients with a mean nodule size of 3.5 ± 1.6 cm, clinical follow-up was recommended. The mean duration of follow-up was 20.5 months for 74 patients, and 6 patients were lost to follow-up. Nodule resolution was observed in 7 patients. Repeat FNAB was performed in 45 patients and was benign in 39 (87%), nondiagnostic in 2 (4%), cellular in 3 (7%), and malignant in 1 (2%). Thyroidectomy was performed in the patients with the cellular and malignant aspirates, and the pathology was adenomatous hyperplasia (2), follicular adenoma (1), and papillary carcinoma (1). Thyroidectomy was performed for increasing nodule size and/or compressive symptoms in 41 patients with a mean nodule size of 5.7 ± 1.9 cm, 19 of whom had substernal extension (P < 0.05). Pathology included benign disease in 39, papillary cancer in 1, and lymphoma arising in Hashimoto's thyroiditis in 1 patient. Given that repeat FNAB was of value in only 1 patient and the false-negative rate for FNAB was only 2.5 per cent, the routine use of repeat FNAB in patients with benign nodular thyroid disease may not be justified. Development of compressive symptoms and diagnosis of unsuspected malignancy in patients with nodule enlargement, including lymphoma in patients with Hashimoto's thyroiditis, underscores the importance of long-term follow-up.
Alteration of the Roux Stasis Syndrome by an Isolated Roux Limb: Correlation of Slow Waves and Clinical Course
Authors: Zonca Stephen , Rizzo Paul
Published: November 2022

The Roux-Y stasis syndrome after antrectomy and vagotomy has been well described. Delayed gastric emptying after vagotomy and antrectomy with Roux-Y anastomosis has been attributed to loss of the duodenal pacemaker and to the effects of retrograde slow-wave activity arising from distal small bowel pacemakers. Small bowel contractions are closely coupled with slow-wave activity. Transection and anastomosis of the small bowel distal to the jejuno-jejunostomy has been shown to electrically isolate the Roux limb from distal small bowel pacemakers. Using a canine model, a vagotomy and hemigas-trectomy with Roux-Y were performed in five dogs using the standard operation (control); in four dogs (experimental), an additional transection and reanastomosis of the jejunum 25 cm distal to the Y anastomosis of the Roux limb was performed. All specimens had six electrodes implanted along the Roux limb at 5-cm intervals, used for weekly analysis of the jejunal slow-wave activity. The isolated loop cohort had reduced incidence of retrograde slow waves, reduced emesis, improved gastric emptying by upper gastrointestinal series, and reduced gastric pouch size at autopsy. Adding a distal transection and anastomosis, thus creating an isolated Roux-Y segment, may improve the course of the Roux stasis syndrome.
Cryosurgical Effects on Growing Vessels
Authors: Ladd Alan P. , Rescorla Frederick J. , Baust John G. , Callahan Michael , Davis Mary , Grosfeld Jay L.
Published: November 2022

Cryosurgical treatment of unresectable hepatic malignancies has proven beneficial in adults. Concerns regarding its use in children include the effect on growth and the risk of injury to adjacent structures. To test the effect of cryoablation on adjacent vascular structures in a growing animal, liquid nitrogen cryoablation was performed on a juvenile murine model. Sprague Dawley rats underwent double freeze-thaw cryoablation of the abdominal aorta with interposed liver tissue. Serial sacrifices were performed over 120 days. Comparisons were made with sham-operated controls. Overall, animal growth paralleled that of sham controls through all time points. Gross examination of aortic diameter also showed similar growth in vessel size between the groups. Histologic analysis demonstrated injury after cryoablation with smooth muscle cell vacuolization, followed by cell death. Aortic media layer collapse resulted from cellular loss, however, elastin fiber composition was maintained. Aortic patency was preserved despite evidence of cellular injury and aortic wall remodeling. An associated thermal sink effect on the opposing wall was identified. After cryoablation adjacent to the abdominal aorta in adolescent rats, vascular patency is maintained and animal growth and structural function is preserved, despite cellular injury and wall compression. These observations suggest that cryoablation may be a useful treatment adjunct in young subjects.
Childhood Farm Injuries
Authors: Zietlow Scott P. , Swanson Jill A.
Published: November 2022

During a recent 6-year period (1991–1997), 143 children and adolescents less than 18 years of age were admitted to a Level I trauma center for agriculture-related trauma. Mechanized pieces of equipment were responsible for half of the injuries. The pattern of injury was clearly seasonal and a daytime occurrence. Half of the patients came from the scene and half from rural hospital emergency rooms, with only 25 per cent being transported via advanced life support. Rural geography led to both long distance (mean, 55 miles) and long transport time to definitive care (mean, 2 hours, 15 minutes). There was a predilection for fractures, amputations, head injuries, and soft-tissue infections. Operative intervention was required immediately in two- thirds, and one-third were admitted to an intensive care unit. Whereas hospital mortality was low at 1.4 per cent, most childhood farm deaths during the study period occurred in the field. Severe permanent disability was present in one-third of children, and 7 per cent incurred a second injury during the study period. Using this review, prevention programs have been developed to minimize death and disability in children sustaining farm injuries.
Stereotactic Breast Biopsy in a Community Hospital Setting
Authors: Klem David , Jacobs H. Kurt , Jorgensen Richard , Facenda Linda S. , Baker Dennis A. , Altimari Anthony
Published: November 2022

Our institution began using a stereotactic core needle breast biopsy system for mammographically detected breast lesions in November 1996. The system consists of a LORAD stereo imaging table and an 11-gauge vacuum-assisted mammotome (Biopsys Medical, Irvine, CA). All biopsies were performed with the combined efforts of a radiologist and a surgeon. Three hundred sixteen biopsies were attempted in 279 patients, with multiple biopsies in 31 patients. Indications included microcalcifications in 52 per cent of patients and a mass in 48 per cent of patients. Biopsy was unsuccessful in 20 patients (6.3%). Pathologic diagnoses included invasive ductal carcinoma (19 patients), invasive lobular carcinoma (2), ductal carcinoma in situ (17), atypical ductal hyperplasia (8), atypical lobular hyperplasia (1), fibroadenoma (40), lymph node (7), and benign (202). Invasive cancer, in situ carcinoma, or atypical hyperplasia was diagnosed in 46 (15.6%) lesions. Thirty-six patients had open biopsies. The core biopsy diagnosis was correct in 27 lesions, unable to be confirmed in six cases and changed in four cases, with three lesions upgraded and one case downgraded. The 11-gauge vacuum-assisted mammotome provides excellent accuracy for diagnosing mammographic abnormalities. A combined effort between radiology and surgical services is an effective way of using the stereotactic biopsy system.
Tracheal and Laryngeal Resections for Differentiated Thyroid Cancer
Authors: Talpos Gary B.
Published: November 2022

Extensive local invasion of the trachea or larynx by differentiated thyroid cancer has usually resulted in a conservative therapeutic approach, including at least a thyroid biopsy and external beam irradiation. Thyroidectomy, if performed, has also allowed radioactive iodine administration with variable uptake. Survival rates are rarely reported, but generally considered dismal. In light of this, an aggressive surgical approach was initiated with attempted resection of all local tumor tissue. Seven patients (five females and two males), 38 to 82 years of age (mean, 64), underwent tracheal sleeve resection for obstructing lesions (four patients) or partial laryngectomy (three patients) for locally invasive tumors. Esophageal resections were included in two patients. Follicular cancer was seen in two patients; Hürthle cell cancer was seen in three patients; and papillary cancer was seen in two patients. Patients were also treated with radioactive iodine and external beam irradiation. Patients were followed regularly postoperatively to establish survival. No operative deaths were seen. Two patients died of disease at 57 and 47 months postoperatively. One died of natural causes 24 months after surgery. Four patients are alive at 10, 29, 114, and 118 months after resection. Mean survival, to date, is 51.3 months. Aggressive attempts at surgical resection of differentiated thyroid cancers seems warranted for tumors obstructing the trachea or involving the larynx. It has been well tolerated and is associated with a >4-year average survival. A nihilistic approach no longer can be justified in these patients.
Comparison of Laparoscopic and Open Ventral Herniorrhaphy
Authors: Ramshaw Bruce J. , Esartia Playton , Schwab Jeff , Mason Edward M. , Wilson Russell A. , Duncan Titus D. , Miller Jacqueline , Lucas George W. , Promes John
Published: November 2022

The repair of large and/or recurrent ventral hernias is associated with significant complications and a recurrence rate that can be more than 50 per cent. Laparoscopic ventral herniorrhaphy, a recent development, has been shown to be safe and effective in the repair of ventral hernias. This study retrospectively reviews all ventral hernia repairs over a 3-year period, November 1995 through December 1998, at a community-based teaching hospital. The purpose of the study was to compare open and laparoscopic repairs. A total of 253 ventral hernia repairs were performed during this time, 174 open and 79 laparoscopic. The age, weight, and sex distribution was similar for each group. The hernias in the open group averaged 34.1 cm2 in size, and mesh used averaged 47.3 cm2. In the laparoscopic group, the hernia defect averaged 73.0 cm2, and the mesh size averaged 287.4 cm2. Operative time was longer in the open group, 82.0 versus 58.0 minutes. In the open group, there were 38 (21.8%) minor and 8 (4.6%) major complications, compared with 13 (16.5%) minor and 2 (2.5%) major complications in the laparoscopic group. Hospital stay was shorter for the laparoscopic group, 1.7 versus 2.8 days. At an average follow-up of 21 months (range, 2–40 months), there have been 36 recurrences in the open group (20.7%) compared with 2 recurrences in the laparoscopic group (2.5%). In this series, laparoscopic ventral herniorrhaphy compares favorably to open ventral herniorrhaphy with respect to wound complications, hospital stay, operative time, and recurrence rate.
Improved Antibody Responses to Delayed Pneumococcal Vaccination in Splenectomized Rats
Authors: Werner Andrew M. , Solis Maurice M. , Vogel Robert , Southerland Sheila S. , Ashley Angela V. , Floyd John C. P. , Brown Christopher , Ashley Dennis W.
Published: November 2022

Pneumococcal vaccination following splenectomy is widely used as prophylaxis against overwhelming postsplenectomy infection. There remains controversy however, over the timing of vaccination. We hypothesized that delaying vaccination would increase the antibody response. Pneumococcal vaccinations were given at designated intervals to rats that had undergone either a sham abdominal surgery or splenectomy. Sixty male Sprague-Dawley rats, 250 to 400 g, were divided into three groups for vaccination: I, 1 day postoperatively; II, 7 days postoperatively; and III, 28 days postsplenectomy/sham. Serum antibody levels were then determined by enzyme-linked immunosorbent assay at 5 and 21 days after vaccination. Immunoglobulin (Ig) levels after delayed vaccination at 1 week postoperatively and 1 month postoperatively were significantly higher than levels from rats vaccinated 1 day postoperatively. IgM levels after vaccinations 1 week and 1 month postoperatively were also significantly higher than levels of rats vaccinated 1 day postoperatively (P < 0.05 for both IgG and IgM). On the basis of these results, we conclude that delaying vaccination after splenectomy enhances antibody responses.
Prognostic Factors in Patients with Inferior Vena Cava Injuries
Authors: Rosengart Matthew R. , Smith Donald R. , Melton Sherry M. , May Addison K. , Rue Loring W.
Published: November 2022

Inferior vena cava (IVC) injuries are potentially devastating insults that continue to be associated with high mortality despite advances in prehospital and in-hospital critical care. Between 1987 and 1996,37 patients (32 males and 5 females; average age, 30 years) were identified from the trauma registry as having sustained IVC trauma. Overall mortality was 51 per cent (n = 19), with 13 intraoperative deaths and five patients dying within the first 48 hours. Blunt IVC injuries (n = 8) had a higher associated mortality than penetrating wounds (63% versus 48%). Of the 29 patients with penetrating IVC trauma, the wounding agent influenced mortality (shotgun-100% versus gunshot-43% versus stab-0%). Anatomical location of injury was also predictive of death [suprahepatic (n = 3)-100% versus retrohepatic (n = 9)–78% versus suprarenal (n = 6)–33% versus juxtarenal (n = 2)–50% versus infrarenal (n = 15)–33%]. A direct relationship existed between outcome and the number of associated injuries: nonsurvivors averaged four and survivors averaged three. Eighty per cent of patients sustaining four or more associated injuries died, by contrast to a 33 per cent mortality in those suffering less than four injuries. Physiological factors were also predictive of outcome. Patients in shock (systolic blood pressure <80) on arrival had a higher mortality than those who were hemodynamically stable (76% versus 30%). Preoperative lactate levels were of prognostic value for death (≥4.0–59% versus <4.0–0%), as was base deficit (<4–22%, ≥4, and <10–36%, ≥10–73%). Interestingly, neither time from injury to hospital arrival (47.4 minutes versus 33.0 minutes) nor time in the emergency department before surgery (45.6 minutes versus 42.6 minutes) differed between survivors and fatalities. Mortality remained high in the 34 patients who had operative control of their IVC injuries [lateral repair (n = 27)–44% versus ligation (n = 6)–66% versus Gortex graft (n = 1)–0%]. As wounding agent, anatomical location, associated injuries, and physiological status seem to most directly impact mortality, future efforts must focus both on establishing prevention programs directed at reducing the incidence of this injury, as well as on advancing the management of those who do survive to hospitalization, if we are to improve on the outcome of these devastating injuries.
Dog Bite Injuries in Children: A Preliminary Survey
Authors: Gandhi Rajesh R. , Liebman Monica A. , Stafford Bethany L. , Stafford Perry W.
Published: November 2022

Dog bite injuries in children are a preventable health problem. To characterize this type of injury, we have undertaken to define demographic criteria and patterns of injury inflicted by dogs in our pediatric population. A retrospective chart review was conducted of pediatric patients with dog bite injuries admitted to a Level I pediatric trauma center from January 1986 through June 1998. Patient demographics, canine characteristics, and hospital patient data were collected and analyzed using the Excel program and appropriate statistical methodology. There were 67 patient records reviewed. Thirty-eight (57%) of the patients were male, and 29 (43%) were female. There were 43 (64%) white children, 22 (33%) African-American children, and 2 (3%) Hispanic children. The average age of the children was 6.2 ± 4.2 years, with an average weight of 23.3 ± 13.7 kg. More than half the attacks occurred in the afternoon and 55 per cent of these attacks were documented as “unprovoked” attacks. Thirty-one (46%) of these attacks involved family pets, and 30 (45%) dogs were known to the attacked child. The head and neck was involved in greater than 67 per cent of these injuries. Pit bulls caused 25 per cent of the bite injuries. Large dogs were responsible for 88 per cent of the attacks. Forty-four (66%) patients required operative intervention. Twenty-eight of these patients had multiple anatomical areas injured. There were 44 procedures involving the head and neck, 21 involving extremities, and 6 involving other areas of the body. All patients 5 years of age and under had head and neck injuries. Dog bite injuries requiring admission occur more in male children. Caucasian and African American children were the majority of children affected. The children under 5 years of age suffered the most devastating injuries. More than half of these attacks were not provoked. More than two-thirds of the injuries to these children involved the head and neck. We conclude that effective prevention strategies must stress careful supervision of young children and the family or neighbor's dog, a scenario that may easily lead to complacency and set the stage for a severe injury.
The Underestimated Impact of Personal Watercraft Injuries
Authors: White Mark W. , Cheatham Michael L.
Published: November 2022

The popularity of personal watercraft is steadily increasing, as are injuries related to their use. Many of these injuries are not reported to law enforcement agencies, and available personal watercraft injury statistics are suspected to be inaccurate. All personal watercraft-related injuries treated within a four-hospital system (including the regional Level I trauma center) between January 1993 and December 1997 were retrospectively identified. Patient demographics, accident mechanism, injuries sustained, tourist status, outcome, and economic data were collected and compared with available government statistics for the same time period. Sixty-eight consecutive patients injured during personal watercraft use were identified. Of these, 78 per cent were treated and released, whereas 22 per cent required inpatient management. Fractures and soft tissue injuries were the most common injuries sustained. Ninety-seven per cent of patients were discharged home. There was one fatality. Comparison with state and federal statistics identified that personal watercraft injuries are significantly underreported and have an estimated yearly economic impact of more than $235 million. Personal watercraft injuries represent an increasing source of watersport-related trauma. Government statistics on personal watercraft injuries do not accurately reflect the true incidence and economic impact of such trauma. Mandatory educational programs and increased legislation to improve personal watercraft safety should be promoted.
All-Terrain Vehicle Injuries in Children: Industry-Regulated Failure
Authors: Ross R.T. , Stuart Lynn K. , Davis Frank E.
Published: November 2022

Although the sale of all-terrain vehicles (ATVs) to children under 16 years of age was prohibited in 1988, they continue to represent half of the ATV-associated injuries. We conducted a retrospective review of ATV injuries admitted to our institution from 1988 to 1998. We identified 76 patients over the last 10 years, with 50 patients admitted in the last 4 years. Children <16 years of age account for 50 per cent of all ATV-injured patients. Only eight per cent of these children wore helmets. We conclude that despite industry regulation, nearly half of ATV injuries continue to involve children under 16 years of age. The consent decree restricting access of children <16 years of age to ATVs has been ineffective and expired in April 1998. Significant morbidity and mortality continues to occur in children <16 years of age who operate these vehicles. Reform is needed, such as legislation that would mandate the sale of safety equipment on ATV purchase, as well as provide for ATV safety education.
Simplifying the Waterston's Stratification of Infants with Tracheoesophageal Fistula
Authors: Dunn James C. Y. , Fonkalsrud Eric W. , Atkinson James B.
Published: November 2022

The survival of infants with tracheoesophageal fistula was stratified by David J. Waterston et al. in 1962. This classification has been used as a guide to direct the timing of operative intervention in these infants. This study examines the current applicability of this classification system. The hospital records of 64 infants with esophageal atresia and/or tracheoesophageal fistula were reviewed. The survival rate was analyzed as a function of the infants’ risk stratification, birth weight, and additional anomalies. Twenty-three infants were in Waterston Group A, 20 infants in Group B, and 21 infants in Group C. The survival of all infants was 81 per cent. Six infants died after recognition of severe anomalies and withdrawal of care, four infants died of cardiopulmonary arrest, and two infants died of sepsis. The survival of infants in both Groups A and B was 100 per cent, in contrast to 43 per cent survival in Group C. Only infants who weighed <1800 g or had severe additional anomalies were at risk of dying. Therefore, the classification of infants with esophageal atresia and/or tracheoesophageal fistula may be simplified by combining Waterston's Groups A and B into a single risk stratum.
Clinical Use of a Bioartificial Liver in the Treatment of Acetaminophen-Induced Fulminant Hepatic Failure
Authors: Detry Olivier , Arkadopoulos Nikolaos , Ting Paul , Kahaku Elaine , Watanabe Frederick D. , Rozga Jacek , Demetriou Achilles A.
Published: November 2022

Patients with acetaminophen-induced fulminant hepatic failure (FHF) who meet the King's College Hospital criteria have a high mortality risk (>90%) if they do not undergo liver transplantation. We have developed a treatment strategy for these patients based on the use of an extracorporeal bioartificial liver (BAD support system. In this study, we report the results of the clinical application of BAL support in patients with acetaminophen-induced FHF. All patients were admitted to a dedicated surgical intensive care unit. They were evaluated for urgent liver transplantation and received the standard medical measures, including N-acetylcysteine administration and intracranial pressure monitoring. Moreover, they underwent daily 6-hour BAL treatments. Eight patients were treated. Three patients were bridged to liver transplantation, and five patients recovered without a transplant. All patients experienced neurological and metabolic improvement after treatments with the BAL support system. The BAL support system seems to improve the outcome of high-risk patients with acetaminophen-induced FHF, even in the absence of liver transplantation. Avoiding liver transplantation is particularly important in an era of organ shortage and high cost of transplants.
Current Management of Recurrent Pyogenic Cholangitis
Authors: Cosenza Carlos A. , Durazo Francisco , Stain Steven C. , Jabbour Nicolas , Selby Robert R.
Published: November 2022

Recurrent pyogenic cholangitis (RPC) is a chronic disease with multiple exacerbations requiring repeated biliary dilatation and stone removal. Even after adequate biliary drainage, most patients will have progression of intrahepatic disease. Management of patients with RPC is a multidisciplinary challenge for endoscopists, interventional radiologists, and surgeons because of the frequency and inaccessibility of strictures and stones. Complete stone clearance at any one operation is difficult. Hepaticojejunostomy with a subcutaneous afferent limb is a safe and effective way to provide access to the biliary tree for the management of patients with RPC. In our experience, trans-stomal cholangioscopic stricture dilatation followed by stone removal remains the basis of therapy in patients with RPC. By diligent surveillance, we should be able to eliminate or decrease the number of stones and prevent cholangitis and its sequelae.
Axillary Dissection after Unsuccessful Sentinel Lymphadenectomy for Breast Cancer
Authors: Guenther J. Michael
Published: November 2022

Intraoperative lymphatic mapping and sentinel lymphadenectomy (LM/SL) has been demonstrated to provide sensitive axillary staging for breast cancer. LM/SL has a steep learning curve, and factors associated with unsuccessful LM/SL are not well known. Two hundred sixty patients with breast carcinoma and clinically negative axillae underwent injection of about 5 cm3 of isosulfan blue dye (Lymphazurin, US Surgical Corp, Norwalk, CT) into breast tissue surrounding a cancer or biopsy site. After 5 minutes of breast compression, blue-stained lymph nodes were sought. In 47 patients, no blue nodes were detected; a standard axillary dissection was performed. All 47 patients were women with a mean age of 56 years (range, 34–80). Ductal carcinoma was most common (91.5%). Mean tumor size was 1.99 cm. Axillary dissection yielded a mean of 15.8 lymph nodes (range, 6–35). Sixteen patients (34%) had positive lymph nodes (mean, 7.6; median, 6; range, 1–24). Factors associated with LM/SL difficulty include surgeon inexperience, medial hemisphere primary location, extensive axillary metastases, and extranodal invasion. Inability to identify a sentinel node in a clinically negative axilla is a risk factor for extensive axillary tumor burden. Axillary dissection should be performed for patients with unsuccessful LM/SL, particularly those with lateral hemisphere primaries.
Objective Assessment of Axillary Morbidity in Breast Cancer Treatment
Authors: Kakuda James T. , Stuntz Michael , Trivedi Vaishali , Klein Stanley R. , Vargas Hernan I.
Published: November 2022

Historically, axillary lymph node dissection (ALND) was a critical aspect of the operative management of breast cancer. Recently, the role of ALND has been questioned, with postoperative morbidity possibly overshadowing patient benefit. Our objective was to quantitatively assess the long-term morbidity of ALND in patients with breast cancer. We conducted a cross-sectional study of patients being followed by the Breast Surgery Clinic at a university-affiliated urban hospital. Ninety-five patients with unilateral breast cancer who had undergone ALND were evaluated at routine follow-up visits in the latter half of 1998. A questionnaire was used to quantify the degree of subjective findings, including arm swelling, chest wall pain, decreased mobility, and weakness. Upper extremity strength, active range of motion, and circumference were measured. Overall, 70 per cent of patients had at least one complaint, with 18 per cent having moderate to severe symptoms. Twenty-one per cent had notable decrements in strength or range of motion, 9.3 per cent of patients required chronic compression garments for lymphedema, and 6.4 per cent changed their vocational status because of surgical morbidity. We conclude that adverse effects from ALND occur commonly. Objective findings are less common, perhaps causing clinicians to underappreciate postoperative morbidity. A significant subset of patients had enduring disability.
Minimally Invasive Endoscopic Video-Assisted in Situ Bypass: First 15 Cases
Authors: Kram Harry B. , Uriu Masashi
Published: November 2022

The purpose of the present study was to determine the feasibility of endoscopic video-assisted (EVA) in situ bypass with greater saphenous vein (SV) for femorotibial revascularization. Fifteen consecutive patients who underwent EVA lower extremity revascularization were included in the present report. EVA in situ bypass was successfully accomplished in 12 of 15 (80%) patients. Two patients had major SV injuries (endoscopic scissors), and 6 patients had minor SV injuries (dissecting ring, clip applicator, valvulotome). Postoperatively, 2 patients developed subcutaneous abscesses in the thigh graft tunnel, and 5 patients developed minor calf wound necrosis. Eight of 12 (67%) EVA in situ bypasses were patent at 6- to 32-month follow-up (mean, 24 months), and 2 of 12 (17%) patients died with patent EVA in situ bypasses; one other patient experienced EVA in situ bypass thrombosis 6 months postoperatively without further surgical treatment. Ten of 12 (83%) patients who underwent EVA in situ bypass had successful surgical outcomes, and 11 of 12 (92%) avoided major amputation; 1 patient eventually required below-knee amputation because of nonhealing foot lesions despite a patent EVA in situ bypass. We conclude that EVA in situ bypass with SV is a practical technique for limiting the length and number of incisions necessary to completely eliminate SV tributaries. On the basis of experience gained from the present series, we recommend the following: 1) strategic placement of the initial small skin incisions to maximize exposure of the SV and inflow/outflow arteries; 2) beginning gas insufflation into the perivenous space during initial SV dissection, rather than after creation of the perivenous tunnel; 3) no transection of clipped SV tributaries with the endoscopic scissors; 4) minimal use of the dissecting ring to expose the SV and its tributaries, instead using continuous gas insufflation and the balloon dissector; and 5) completion angiography to inspect the bypass graft and runoff.
Ventral Hernia Synthetic Mesh Repair Infected by Mycobacterium fortuitum
Authors: Matthews Marc R. , Caruso Daniel M. , Tsujimura Ryan B. , Smilack Jerry D. , Pockaj Barbara A. , Malone James M.
Published: November 2022

We report the occurrence of a refractory infection caused by the “rapidly growing” nontuberculous mycobacterium, Mycobacterium fortuitum, after incisional hernia repair using synthetic mesh. The patient had previously undergone three herniorrhaphies incorporating polypropylene mesh. Multiple surgical debridements were required, along with complete removal of all the mesh, to eradicate the infection. Prolonged antimicrobial therapy with sulfamethoxazole, an agent active against the patient's isolate, was also used. Although this atypical mycobacterium has been reported to cause a variety of infections, including many types of periprosthetic infections, this case represents successful treatment of M. fortuitum infecting abdominal wall mesh.
Upper Arm Arteriovenous Fistulas as a Reliable Access Alternative for Patients Requiring Chronic Hemodialysis
Authors: Livingston Chrisopher K. , Potts John R.
Published: November 2022

The wrist fistula is the access procedure of choice in the hemodialysis patient. However, unavailable or unusable anatomy in this aging population has made them difficult to establish. This study retrospectively compares patency, occlusion, and complication rates of upper arm arteriovenous fistulas (AVFs) as a reliable alternative. Fifty-eight upper arm AVFs were created in 52 patients between February 1995 and August 1997 at Hermann Hospital, affiliated with the University of Texas Health Science Center in Houston, Texas. Fistulas were constructed using the brachial artery (BA) side-to-end (n = 56) or side-to-side (n = 1) with either the cephalic vein (CV; n = 39), transposed basilic vein (TBV; n = 16), or other vein [basilic vein (BV; n = 1), transposed cephalic vein (TCV; n = 1), median cubital vein (MCV; n = 1)]. One-year primary patency rates for upper arm AVFs were 66 per cent, and secondary patency rates were 22 per cent. Flow rates averaged 354.6 mL/minute. Primary and secondary patency rates for fistulas created are: BA-CV (67% and 20%), BA-TBV (63% and 25%), and other upper arm AVFs 66 per cent without revisions. Primary patencies for both BA-CV and BA-TBV fistulas were similar to previously reported studies. Secondary patencies proved to be less effective. Upper arm AVFs should be considered before graft placement when wrist and forearm anatomy does not lend itself to fistula creation.
Microbiology of Subphrenic Abscesses: A 14-Year Experience
Authors: Brook Itzhak , Frazier Edith H.
Published: November 2022

The objective of the review was to study the aerobic and anaerobic microbiology of subphrenic abscesses in relation with predisposing conditions. A retrospective review of clinical and laboratory data of 52 patients treated between 1974 and 1988 was conducted. Forty-three (83%) patients developed the abscesses after an operative procedure. These included 11 patients after colonic, 9 patients after gastric or duodenal, 7 patients after abdominal trauma, 7 patients after biliary, and 6 patients after appendix surgery. A total of 194 organisms (3.7 isolates/specimen), 83 aerobic (1.6/specimen), and 111 anaerobes (2.1/specimen) were recovered. Aerobic bacteria only were recovered in 7 (13%) abscesses, anaerobic bacteria only in 11 (21%), and mixed aerobic and anaerobic bacteria in 34 (65%). Polymicrobial infection was present in 47 (90%). The predominant aerobic isolates were Escherichia coli (28 isolates), Enterococcus group D(9), and Staphylococcus aureus (9). The predominant anaerobes were Peptostreptococcus species (33 isolates), Bacteroides fragilis group (25), Clostridium species (13), and Prevotella species (6). The number of isolates/site varied. The number of anaerobic bacteria/site outnumbered or was equal to the number of aerobic or facultatives in all instances, except in abscesses after biliary surgery. Their number/site was especially high in abscesses after appendectomy, and the number of aerobic and anaerobic bacteria was the lowest after gastric or duodenal surgery. S. aureus predominated after gastric, duodenal and posttrauma surgery; B. fragilis predominated after colonic, appendix, and postabdominal trauma surgery; Enterococcus group D predominated after biliary surgery; Fusobacteriutn and Prevotella species predominated after gastric or duodenal surgery; and Clostridium species predominated after colonic or appendix surgery. These data highlight the polymicrobial aerobic-anaerobic nature of subphrenic abscesses and their correlation with predisposing surgery.
Missed Injuries in Pediatric Trauma
Authors: Peery Curtis L. , Chendrasekhar Akella , Paradise Norman F. , Moorman Donald W. , Timberlake Gregory A.
Published: November 2022

Missed injuries in trauma continue to be a nemesis to the trauma surgeon. Missed injuries in adult trauma patients range in frequency from 9 to 28 per cent, with some being life threatening or permanently disabling. We report the incidence of missed injuries in pediatric trauma to be 20 per cent, in our retrospective review of 107 severe pediatric trauma patients. These missed injuries, however, were neither life threatening nor permanently disabling. We also found that mechanism of injury and patient age affected the incidence of missed injuries in our population.
Cryosurgery: Adjuvant Treatment at the Time of Resection of a Pelvic Recurrence in Rectal Cancer
Authors: Sardi Armando , Ojeda Herminio , Barco Eric
Published: November 2022

We report a case in which cryosurgical ablation was used to treat recurrent rectal cancer. Several years after low anterior resection for rectal cancer, the patient was found to have a large pelvic recurrence with involvement of the presacral space. After resection of the pelvic mass, cryosurgery was applied to the presacral space, extending to the lateral pelvic wall and up to the sacral promontory. After a 24-month follow-up, the patient remains disease-free with a Karnofsky performance status of 100 per cent. Cryosurgery can be used as an adjuvant therapy at the time of resection to successfully treat a pelvic recurrence.
High-Frequency Oscillatory Ventilation Can be Effective as Rescue Therapy for Refractory Acute Lung Dysfunction
Authors: Claridge Jeffrey A. , Hostetter Roy G. , Lowson Stewart M. , Young Jeffrey S.
Published: November 2022

High-frequency oscillatory ventilation (HFOV) is a technique with limited use in adult patients. The main purpose of this pilot study was to evaluate HFOV on adult trauma patients with refractory lung dysfunction. Refractory lung dysfunction was defined as a PaO2:FiO2 ratio <75 for 1 hour despite maximum support via conventional mechanical ventilation (CMV). Five patients were placed on HFOV after failing CMV between May 1998 and December 1998. The mean PaO2:FiO2 ratio at the time of initiation (52.2 ± 4.73) of HFOV increased significantly (P < 0.05) by 2 hours (126.8 +21) and was still significantly increased (P < 0.01) after 48 hours (181 +26.1) on HFOV. The mean airway pressures (MAPs) and peak pressures were significantly lower (P < 0.01) after HFOV. The average MAP of the five patients was 34.6 +1.6 cm H2O at time zero and 25.2 cm H2O after 48 hours of HFOV. The mean peak pressure was 52.4 +3.0 cm H2O at time zero and was 35.8 ± 3.01 after termination of HFOV. Survival was 80.0 per cent (four of five patients). In conclusion, all patients improved after initiation of HFOV, and HFOV should be considered in the treatment of patients with acute refractory lung dysfunction.
Operative Management of Severe Constipation
Authors: Lahr Stephanie J. , Lahr Christopher J. , Srinivasan Ajai , Clerico Elizabeth T. , Limehouse Vicki M. , Serbezov Ianko K.
Published: November 2022

This report investigates the concept that severe constipation requiring major abdominal surgery may result from one of three common causes: 1) colonic inertia, 2) pelvic hiatal hernia, or 3) both colonic inertia and pelvic hernia. This study evaluates the symptoms, anatomy and outcome in 201 patients with severe surgical constipation treated by a single surgeon. In 2042 patients with constipation referred to one colon and rectal surgeon, 211 major abdominal surgical procedures were performed on 201 patients for severe constipation between 1989 and 1999. There were 187 women and 14 men. Mean age was 49 years (range, 9–84). Five high-risk patients had ileostomy; 196 had major colonic surgery for anatomic or physiologic causes of constipation, excluding malignancy, diverticular disease, and inflammatory bowel disease. Pelvic hiatal hernia was defined as the herniation of bowel through the hiatus of the pelvic diaphragm seen on pelvic videofluoroscopy or physical examination. Of these 196 patients, 44 per cent had pelvic hiatal hernia repair (PHHR), 27 per cent had total abdominal colectomy and ileorectal anastomosis for colonic inertia, and 29 per cent had surgery for both colonic inertia and pelvic hiatal hernia. Of the 144 patients undergoing PHHR, 95 had Gore-Tex® patch (W. L. Gore and Associates, Inc., Phoenix, AZ) sacral colpopexy. PHHR for pelvic hiatal hernia without colonic inertia included sigmoid resection, rectopexy, and Gore-Tex patch sacral colpopexy. Mean duration of follow-up was 20 months. Symptoms noted preoperatively included abdominal pain (84%), straining at stool (90%), incomplete rectal emptying (85%), painful bowel movements (74%), pelvic pain (69%), vaginal bulge (55%), digital assistance with evacuation (35%), and incontinence of stool (38%). Outcome assessed by symptom relief was successful in 89.1 per cent of patients. 8.6 per cent of patient conditions were unchanged, and 2.3 per cent were unsatisfied with the outcome. There were no postoperative deaths. The complication rate was 6.1 per cent (small bowel obstruction, 7; anastomotic leak, 2; ureteral stenosis, 2; and patch erosion, 1). In our experience, severe surgical constipation can be due to colonic inertia, pelvic hiatal hernia, or both. Careful preoperative evaluation identifies these disorders, and surgical therapy aimed at correction of anatomic and physiologic defects results in high patient satisfaction and improvement in bowel function.