bluuebunny/crossref_metadata_2025 huggingface dataset:
Neuroprotective effect ofPanax ginsengextract against cerebral ischemia–reperfusion-injury-induced oxidative stress in middle cerebral artery occlusion models
Authors: Shamim Mufzala , Khan Nazish Iqbal
Published: March 2019

The present study investigated the in vivo neuroprotective role of Panax ginseng extract (PGE) pretreatment against transient cerebral ischemia in a middle cerebral artery occlusion (MCAO) model. Rats were randomly divided as follows: group I, control; group II, sham-operated; group III, where animals were subjected to MCAO surgery; and group IV, where animals were orally administered 10 mL PGE per day (200 mg/kg of body weight per day) for 30 d followed by MCAO induction at day 31. Following 24 h of reperfusion, blood and tissue (brain, liver, and kidney) samples were collected for biochemical and histopathological examination. Biochemical testing included lipid profile, liver enzymes, kidney function tests, C-reactive protein (CRP), lactate dehydrogenase (LDH), glucose, and total protein estimation. Tissue antioxidants (catalase, superoxide dismutase, and glutathione) were assessed in brain, liver, and kidney tissues. MCAO-induced histopathological changes were also examined in the tissues. Pretreatment with PGE showed significant improvement in tissue antioxidant status in brain, liver and kidney tissues. PGE treatment maintains plasma lipid profile, liver enzymes, kidney function, and CRP, LDH, and glucose levels. Histologically, monocytes and macrophage infiltration were observed in the tissues of MCAO animals, whereas PGE treatment preserved tissue architecture and minimal monocyte infiltration. PGE supplementation showed a neuroprotective effect against ischemia–reperfusion injury by effectively increasing endogenous antioxidant enzyme activity.
Interacting models of generalized Chaplygin gas and modified Chaplygin gas with barotropic fluid
Authors: Biswas Promila , Biswas Ritabrata
Published: March 2019

In this paper, we consider two different models of our present universe. We choose the models which consist of different sets of two separate fluids. The first one of each set tries to justify the late time acceleration and the second one is barotropic fluid. The former model considers our present time universe to be homogeneously filled up by Generalized Chaplygin Gas which is interacting with barotropic fluid. On the other hand, the latter model considers that the cosmic acceleration is generated by Modified Chaplygin Gas which is interacting with matter depicted by barotropic equation of state (EoS). For both the models, we consider the interaction term to vary proportionally with Hubble’s parameter as well as with the exotic matter/dark energy’s energy density. We find an explicit function form of the energy density of the cosmos which is found to depend on different cosmological parameters like scale factor, dark energy and barotropic fluid’s EoS parameters and other constants, like interacting constants, etc. We draw curves of effective EoS-s, different cosmological parameters like deceleration parameter q, statefinder parameters r and s with respect to the redshift z (for different values of dark energy and barotropic fluid parameters) and study them thoroughly. We compare two models as well as the nature of dependencies on these models’ interaction coefficients. We point out the particular redshift for which the universe may transit from a deceleration to acceleration phase. We tally all these values with different observational data. Here, we also analyze how this value of particular redshift does change for different values of interaction coefficients and different dark energy models.
Light-front QED, Stueckelberg field and infrared divergence
Authors: Govindarajan T. R. , More Jai D. , Ramadevi P.
Published: March 2019

Stueckelberg mechanism introduces a scalar field, known as Stueckelberg field, so that gauge symmetry is preserved in the massive Abelian gauge theory. In this work, we show that the role of the Stueckelberg field is similar to the Kulish and Faddeev coherent state approach to handle infrared (IR) divergences. We expect that the light-front quantum electrodynamics (LFQED) with Stueckelberg field must be IR finite in the massless limit of the gauge boson. We have explicitly shown the cancellation of IR divergences in the relevant diagrams contributing to self-energy and vertex correction at leading order.
Professor Chen Ping Yang’s early significant contributions to mathematical physics
Authors: Guan Xi-Wen , He Feng
Published: March 2019

In the 60s Professor Chen Ping Yang with Professor Chen Ning Yang published several seminal papers on the study of Bethe’s hypothesis for various problems of physics. The works on the lattice gas model, critical behavior in liquid–gas transition, the one-dimensional (1D) Heisenberg spin chain, and the thermodynamics of 1D delta-function interacting bosons are significantly important and influential in the fields of mathematical physics and statistical mechanics. In particular, the work on the 1D Heisenberg spin chain led to subsequent developments in many problems using Bethe’s hypothesis. The method which Yang and Yang proposed to treat the thermodynamics of the 1D system of bosons with a delta-function interaction leads to significant applications in a wide range of problems in quantum statistical mechanics. The Yang and Yang thermodynamics has found beautiful experimental verifications in recent years.
Support Set Invariancy for Interval Bimatrix Games
Authors: Hladík Milan
Published: March 2019

Traditionally, game theory problems were considered for exact data, and the decisions were based on known payoffs. However, this assumption is rarely true in practice. Uncertainty in measurements and imprecise information must be taken into account. The interval-based approach for handling such uncertainties assumes that one has lower and upper bounds on payoffs. In this paper, interval bimatrix games are studied. Especially, we focus on three kinds of support set invariancy. Support of a mixed strategy consists of that pure strategies having positive probabilities. Given an interval-valued bimatrix game and supports for both players, the question states as follows: Does every bimatrix game instance have an equilibrium with the prescribed support? The other two kinds of invariancies are slight modifications: Has every bimatrix game instance an equilibrium being a subset/superset of the prescribed support? It is computationally difficult to answer these questions: the first case costs solving a large number of linear programs or mixed integer programs. For the remaining two cases a sufficient condition and a necessary condition are proposed, respectively.
On Finite Extensions of FC-Groups in the Class of NF-Groups
Authors: Chelgham Mourad , Kerada Mohamed , Noui Lamnouar , Araci Serkan
Published: March 2019

Let F, N, A and N2 denote the properties of being finite, nilpotent, abelian and nilpotent of classes at most 2, respectively. Firstly we consider the class of finitely generated FN-groups. We show that the property FC is closed under finite extensions, and extend this result to finitely generated NF-groups. Secondly we prove that a finitely generated NF-group G is in the class ((FC)F, ∞) if and only if G is an FA-group. Finally we prove that a finitely generated NF-group in the class ((FC)F, ∞)* is an FN2-group. Moreover, G/Z2(G) is finite.
Jordan Derivations of Special Subrings of Matrix Rings
Authors: Sayın Umut , Kuzucuoğlu Feride
Published: March 2019

Let K be a 2-torsion free ring with identity and Rn(K, J) be the ring of all n × n matrices over K such that the entries on and above the main diagonal are elements of an ideal J of K. We describe all Jordan derivations of the matrix ring Rn(K, J) in this paper. The main result states that every Jordan derivation Δ of Rn(K, J) is of the form Δ = D + Ω, where D is a derivation of Rn(K, J) and Ω is an extremal Jordan derivation of Rn(K, J).
Evaluation of Transportation Network Reliability under Emergency Based on Reserve Capacity
Authors: Zhang Xiongfei , Zhong Qi , Luo Qin
Published: March 2019

There are differences between the requirements for traffic network for traffic demand in daily and emergency situations. In order to evaluate how the network designed for daily needs can meet the surging demand for emergency evacuation, the concept of emergency reliability and corresponding evaluation method is proposed. This paper constructs a bilevel programming model to describe the proposed problem. The upper level problem takes the maximum reserve capacity multiplier as the optimization objective and considers the influence of reversible lane measures taken under emergency conditions. The lower level model adopts the combined traffic distribution/assignment model with capacity limits, to describe evacuees’ path and shelter choice behavior under emergency conditions and take into account the traits of crowded traffic. An iterative optimization method is proposed to solve the upper level model, and the lower level model is transformed into a UE assignment problem with capacity limits over a network of multiple origins and single destination, by adding a dummy node and several dummy links in the network. Then a dynamic penalty function algorithm is used to solve the problem. In the end, numerical studies and results are provided to demonstrate the rationality of the proposed model and feasibility of the proposed solution algorithms.
Printability and Properties of Conductive Inks on Primer-Coated Surfaces
Authors: Mendez-Rossal Hector R. , Wallner Gernot M.
Published: March 2019

Conductive inks’ performance is affected by the printing conditions and the substrate’s properties. In this study, one graphite-, one polymer-, and two silver-based conductive inks were printed on four primer-coated metal substrates by screen printing. The compatibility and wettability between the inks and the primers were evaluated by infrared spectroscopy and surface energy measurements. The printed structures were characterized by laser confocal microscopy, peel-off tape testing, and four-point probe electrical resistivity testing. In general, silver inks exhibited the best performance in terms of printability and electrical conductivity. The graphite ink presented the worst printing, adhesion, and functional properties. The polymer-based ink revealed poor wettability but good adhesion and functionality. The surface roughness, energy, and polarity of the primer coating had no significant influence on the electrical conductivity of the printed inks.
ROS Induced by KillerRed Targeting Mitochondria (mtKR) Enhances Apoptosis Caused by Radiation via Cyt c/Caspase-3 Pathway
Authors: Li Xin , Fang Fang , Gao Ying , Tang Geng , Xu Weiqiang , Wang Yihan , Kong Ruoxian , Tuyihong Ayixianguli , Wang Zhicheng
Published: March 2019

During radiotherapy, reactive oxygen species- (ROS-) induced apoptosis is one of the main mechanism of radiation. Based on KillerRed which can induce ROS burst in different cell substructures, here we hypothesized that KillerRed targeting mitochondria (mtKR) could induce ROS to enhance apoptosis by radiation. In this study, empty vector, mtKR, and mtmCherry plasmids were successfully constructed, and mitochondrial localization were detected in COS-7 and HeLa cells. After HeLa cells were transfected and irradiated by visible light and X-rays, ROS levels, mitochondrial membrane potential (Δψm), ATPase activities, adenosine triphosphate (ATP) content, apoptosis, and the expressions of mRNA and protein were measured, respectively. Data demonstrated that the ROS levels significantly increased after light exposure, and adding extra radiation, voltage-dependent anion channel 1 (VDAC1) protein increased in the mitochondria, while Na+-K+ and Ca2+-Mg2+ ATPase activities, ATP content, and Δψm significantly reduced. Additionally, the cell apoptotic rates dramatically increased, which referred to the increase of cytochrome c (Cyt c), caspase-9, and caspase-3 mRNA expressions, and Cyt c protein was released from the mitochondria into the cytoplasm; caspase-9 and -3 were activated. These results indicated that mtKR can increase the production of ROS, enhance mitochondrial dysfunction, and strengthen apoptosis by radiation via Cyt c/caspase-3 pathway.
Correlation between Plasma Macrophage Migration Inhibitory Factor Levels and Long-Term Prognosis in Patients with Acute Myocardial Infarction Complicated with Diabetes
Authors: Yu Haiyi , Wang Xinyu , Deng Xiangning , Zhang Youyi , Gao Wei
Published: March 2019

Macrophage migration inhibitory factor (MIF), a widely expressed pleiotropic cytokine, is reportedly involved in several cardiovascular diseases, in addition to inflammatory diseases. Plasma MIF levels are elevated in the early phase of acute cardiac infarction. This study is aimed at investigating the correlation between plasma MIF levels and cardiac function and prognosis in patients with acute ST-segment elevation myocardial infarction (STEMI) with or without diabetes mellitus. Overall, 204 patients with STEMI who underwent emergency percutaneous coronary intervention were enrolled: 57 and 147 patients in the diabetes and nondiabetes STEMI groups, respectively. Sixty-five healthy people were selected as controls. Plasma MIF levels were measured at the time of diagnosis. Basic clinical data and echocardiographic findings within 72 h of admission were collected. Patients were followed up, and echocardiograms were reviewed at the 12-month follow-up. Plasma MIF levels were significantly higher in the diabetes and nondiabetes STEMI groups than in the control group and in patients with Killip grade≥II STEMI than in those with Killip grade I. Plasma MIF levels were negatively correlated with the left ventricular ejection fraction (LVEF) of myocardial infarction in patients with or without diabetes in the acute phase of infarction, whereas the left ventricular diastolic dysfunction (LVDD) was positively correlated. MIF levels in the nondiabetes STEMI group were positively correlated with N-terminal pro-b-type natriuretic peptide levels and were associated with LVEF and LVDD at the 12-month follow-up. The risk of adverse cardiovascular and cerebrovascular events was significantly higher in the MIF high-level group (≥52.7 ng/mL) than in the nondiabetes STEMI group 36 months after presentation. Thus, MIF levels in STEMI patients with or without diabetes can reflect acute cardiac function. In STEMI patients without diabetes, MIF levels can also indicate cardiac function and long-term prognosis at the 12-month follow-up.
The Mechanism of Acupuncture in Treating Essential Hypertension: A Narrative Review
Authors: Li Juan , Sun Mingsheng , Ye Jing , Li Yuxi , Jin Rongjiang , Zheng Hui , Liang Fanrong
Published: March 2019

Essential hypertension has a high incidence worldwide, and patients with essential hypertension endure a lifetime of medication, leading to a heavy economic burden on the patient’s family and causing serious impacts on the patient’s quality of life. Much evidence has demonstrated that acupuncture as an adjunctive therapy can lower blood pressure in patients with hypertension, but the mechanism of its action is unclear. This article reviews the research from 2000 to 2018 regarding the mechanism of acupuncture for hypertension, and we summarize the current knowledge about using acupuncture for hypertension. We found that the mechanism whereby acupuncture lowers blood pressure is related to the regulation of renin-angiotensin-aldosterone system, vascular endothelium, oxidative stress, neuroendocrine system, and so on. Besides, there may be cross-talk between multiple systems and multiple targets. We also investigate the influence factors of acupuncture for hypertension. These results may provide evidence and research ideas for the treatment of hypertension via acupuncture.
A Two‐Level Metaheuristic Algorithm for the Job‐Shop Scheduling Problem
Authors: Pongchairerks Pisut
Published: March 2019

This paper proposes a novel two‐level metaheuristic algorithm, consisting of an upper‐level algorithm and a lower‐level algorithm, for the job‐shop scheduling problem (JSP). The upper‐level algorithm is a novel population‐based algorithm developed to be a parameter controller for the lower‐level algorithm, while the lower‐level algorithm is a local search algorithm searching for an optimal schedule in the solution space of parameterized‐active schedules. The lower‐level algorithm’s parameters controlled by the upper‐level algorithm consist of the maximum allowed length of idle time, the scheduling direction, the perturbation method to generate an initial solution, and the neighborhood structure. The proposed two‐level metaheuristic algorithm, as the combination of the upper‐level algorithm and the lower‐level algorithm, thus can adapt itself for every single JSP instance.
False Positive Cardiotoxicity Events in Cancer-Related Clinical Trials: Risks Related to Imperfect Noninvasive Parameters
Authors: Ewer Michael S. , Herson Jay
Published: March 2019

Purpose: Cardiac ultrasound provides important structural and functional information that makes identification of cardiac abnormalities possible. Left ventricular ejection fraction (LVEF) provides the most commonly used parameter for recognition of treatment-related cardiac dysfunction. Random reading variance and physiologic factors influence LVEF and make the reported value imperfect. We attempt to quantitate the likelihood of false positive events by computer simulation. Methods: We simulated four visits on hypothetical trials. We assumed a baseline LVEF of 55% and normal distribution with regard to reading error and physiologic variation. 1,000 trials of sample size 1,500 were simulated. In a separate simulation, 1,000 patients entered with LVEFs of 45, 43, and 41% to estimate true positive incidence. Results: At each examination, less than 1.0% of false positives were noted. The cumulative false positive rate over four visits was 3.60%. True cardiotoxicity identification is satisfactory only when LVEF declines substantially. Conclusion: A 3.60% false positive rate in trials where the expected level of toxicity is low suggests that false positives are troubling and may exceed true positive results. Strategies to reduce the number of false positive results include making confirmatory studies mandatory. Evaluating increases along with decreases obtains some estimation of variance.
A Phase 2 Study of PCI-27483, a Factor VIIa Inhibitor in Combination with Gemcitabine for Advanced Pancreatic Cancer
Authors: Ramanathan Ramesh K. , Thomas Gary W. , Khorana Alok A. , Shah Satish , Zhou Cathy , Wong Sofia , Cole Jr. George , James Danelle , Gabrail Nashat Y.
Published: March 2019

Objectives: Tissue factor overexpression is associated with tumor progression, venous thromboembolism, and worsened survival in patients with cancer. Tissue factor and activated factor VII (FVIIa) complex may contribute to tumor invasiveness by promoting cell migration and angiogenesis. The study objective was to evaluate safety, pharmacokinetics, and efficacy of PCI-27483, a selective FVIIa inhibitor. Methods: This was an open-label, multicenter phase 2 trial of patients with advanced pancreatic cancer. Part A of the study was an intrapatient dose escalation lead-in portion in patients concurrently receiving gemcitabine, and in part B, patients were randomized 1: 1 to the recommended phase 2 dose combination PCI-27483–gemcitabine versus gemcitabine alone. Results: Target international normalized ratio (between 2.0–3.0) was achieved following PCI-27483 treatment. Overall safety of PCI-27483–gemcitabine (n = 26) was similar to gemcitabine alone (n = 16), with a higher incidence of mostly low-grade bleeding events (65% vs. 19%). Progression-free survival (PFS) and overall survival (OS) were not significantly different between patients treated with PCI-27483–gemcitabine (PFS: 3.7 months, OS: 5.7 months) and those treated with gemcitabine alone (PFS: 1.9 months, OS: 5.6 months). Conclusions: Targeted inhibition of the coagulation cascade was achieved by administering PCI-27483. PCI-27483–gemcitabine was well tolerated, but superiority to single agent gemcitabine was not demonstrated.
Gut Microbiota Profiles in Nonalcoholic Fatty Liver Disease and Its Possible Impact on Disease Progression Evaluated with Transient Elastography: Lesson Learnt from 60 Cases
Authors: Bastian Winda P. , Hasan Irsan , Lesmana C. Rinaldi A. , Rinaldi Ikhwan , Gani Rino A.
Published: March 2019

Background: Dysbiosis of the gut microbiota has been considered to have a role in nonalcoholic fatty liver disease (NAFLD) progression. However, there is still lack of studies regarding this phenomenon. Aim: To find the difference in the proportion of gut microbiota in NAFLD patients based on the stages of liver fibrosis. Patients and Methods: A cross-sectional study was conducted at Dr. Cipto Mangunkusumo Hospital, which is the largest tertiary referral center. Human fecal samples from NAFLD patients who came to the outpatient clinic were collected consecutively. The stool sample examination was performed using an isolation DNA kit (Tiangen) and quantitative real-time polymerase chain reaction (Fast 7500). Clinical and laboratory data were also collected. The stage of fibrosis was diagnosed based on transient elastography (FibroScan® 502 Touch; Echosens, France). Results: Of 60 NAFLD human fecal samples, 35 patients had nonsignificant fibrosis and 25 patients had significant fibrosis (46.7% male and 53.3% female; median age 56 years). Most patients had diabetes (85%), dyslipidemia (58.3%), obesity (58.3%), and central obesity (90%). The proportion of Bacteroides was higher when compared to Lactobacillus and Bifidobacteria. Of these 3 microbiota, the proportion of Bacteroides was significantly higher in the significant fibrosis group when compared to the nonsignificant fibrosis group. Conclusion: There is a change in the composition of gut microbiota in NAFLD patients. The proportion of Bacteroides is significantly higher in significant liver fibrosis, which may play a role in NAFLD progression.
Dual Antiplatelet Therapy Improves Functional Outcome in Patients With Progressive Lacunar Strokes
Authors: Berberich Anne , Schneider Christine , Reiff Tilman , Gumbinger Christoph , Ringleb Peter Arthur
Published: March 2019

Background and Purpose—

In 20% to 30% of patients with lacunar strokes, early neurological deterioration (END) occurs within the first days after stroke onset. However, effective treatment strategies are still missing for these patients. The purpose of this study was to analyze efficacy of dual antiplatelet therapy (DAPT) in patients presenting with END.

Methods—

Four hundred fifty-eight patients with lacunar strokes and corresponding neuroimaging evidence of lacunar ischemia were retrospectively screened for END, which was defined by deterioration of ≥3 total National Institutes of Health Stroke Scale points, ≥2 National Institutes of Health Stroke Scale points for limb paresis, or documented clinical deterioration within 5 days after admission. Patients with END were treated with DAPT according to in-house standards. Primary efficacy end point was fulfilled if National Institutes of Health Stroke Scale score at discharge improved at least to the score at admission. Secondary end points were Rankin Scale score, further clinical fluctuation, and symptomatic bleeding complications.

Results—

END occurred in 130 (28%) of 458 patients with lacunar strokes. Ninety-seven (75%) of these patients were treated with DAPT after END, mostly for 5 days. DAPT was associated with improved functional outcome. The primary end point was met in 68% (66) of patients with DAPT compared with 36% (12) of patients with standard treatment (
P
=0.0019). Further clinical fluctuations were absent in 79% (77) of patients with DAPT versus 33% (11) of patients without DAPT (
P
<0.001). Symptomatic bleeding complications were not observed in any patient.

Conclusions—

The results demonstrated potential positive effects of DAPT in patients with progressive lacunar strokes.
Cellular Statistical Models of Broken Cloud Fields. Part IV: Effects of Pixel Size on Idealized Satellite Observations
Authors: Alexandrov Mikhail D. , Marshak Alexander
Published: March 2019

In the fourth part of our “Cellular Statistical Models of Broken Cloud Fields” series we use the binary Markov processes framework for quantitative investigation of the effects of low resolution of idealized satellite observations on the statistics of the retrieved cloud masks. We assume that the cloud fields are Markovian and are characterized by the “actual” cloud fraction (CF) and scale length. We use two different models of observations: a simple discrete-point sampling and a more realistic “pixel” protocol. The latter is characterized by a state attribution function (SAF), which has the meaning of the probability that the pixel with a certain CF is declared cloudy in the observed cloud mask. The stochasticity of the SAF means that the cloud–clear attribution is not ideal and can be affected by external or unknown factors. We show that the observed cloud masks can be accurately described as Markov chains of pixels and use the master matrix formalism (introduced in Part III of the series) for analytical computation of their parameters: the “observed” CF and scale length. This procedure allows us to establish a quantitative relationship (which is pixel-size dependent) between the actual and the observed cloud-field statistics. The feasibility of restoring the former from the latter is considered. The adequacy of our analytical approach to idealized observations is evaluated using numerical simulations. Comparison of the observed parameters of the simulated datasets with their theoretical expectations showed an agreement within 0.005 for the CF, while for the scale length it is within 1% in the sampling case and within 4% in the pixel case.
Generations in the Feminist and LGBT Movements in Italy: The Case of Non Una Di Meno
Authors: Chironi Daniela
Published: March 2019

The article analyses the participation of young people in emerging social movements, focusing on the experience of the Italian Non Una Di Meno (NUDM) movement combatting male violence against women. Challenging scholarly assumptions of growing youth apathy in democracies, the analysis reveals high levels of participation on the part of the younger population engaged in gender-related struggles. Hit by both conservative and austerity policies associated with the economic and political crisis, feminist and LGBTQI (lesbian, gay, bisexual, transgender, queer, and intersexual) Millennials reacted by increasing their involvement in contentious politics. In the protest arena, they have crossed paths with older generations, activating processes of exchange, but also intergenerational tensions. Based on original qualitative data from ten semi-structured interviews with movement activists in Florence and Bologna, this piece of research sheds light on the role of young people in the birth and evolution of NUDM, and the relationship between different generations of activists within this movement. More specifically, it explains continuities and discontinuities between veterans and younger activists’ sources of theoretical inspirations, organizational models and mobilization resources, strategic priorities and action repertoires. Millennials embrace intersectional feminism and queer theory; opt for grassroots, horizontal organizing; adopt a conflictual attitude towards the state, and dialogical, introspective dynamics within the movement. Intergenerational disagreements especially relate to sex work, and surrogate motherhood.
Lithium can cause hyperthyroidism as well as hypothyroidism: A systematic review of an under-recognised association
Authors: Fairbrother Fiona , Petzl Nicola , Scott James G , Kisely Steve
Published: March 2019

Objective:

Hypothyroidism is a well-documented consequence of lithium treatment. Less well known is a possible association between lithium therapy and hyperthyroidism. This may have clinical implications as rapid changes in thyroid hormones may worsen a person’s affective state, while symptoms of hyperthyroidism can mimic those of mania. We therefore systematically reviewed the published literature for evidence of lithium-induced hyperthyroidism.

Methods:

We searched PubMed, Embase and CINAHL for articles where individuals developed biochemically confirmed hyperthyroidism (with or without clinical symptoms), while on lithium therapy for an affective illness. We included case reports, case series, cross-sectional, case control and cohort studies.

Results:

We included 52 studies, 39 of which were individual case reports and 3 were case series. There were 10 cross-sectional or case control or cohort studies. All the research designs suggested an association between the prescription of lithium and hyperthyroidism. However, these findings were limited by the quality of the included studies, small number of participants and the general lack of either a clear temporal relationship or dose response.

Conclusion:

Hyperthyroidism is an uncommon side-effect of lithium compared to hypothyroidism but may have clinical implications. However, large prospective studies are required to clarify this association and to further inform the management of patients treated with lithium where hyperthyroidism occurs.
Altered social cognition and connectivity of default mode networks in the co-occurrence of autistic spectrum disorder and attention deficit hyperactivity disorder
Authors: Wang Kai , Xu Mingyu , Ji Yiting , Zhang Lingli , Du Xiujuan , Li Jijun , Luo Qiang , Li Fei
Published: March 2019

Objective:

As two common neurodevelopmental disorders, autistic spectrum disorder and attention deficit hyperactivity disorder frequently occur together. Until now, only a few studies have investigated the co-occurrence of attention deficit hyperactivity disorder and autistic spectrum disorder, this is due to restrictions associated with previous Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision. Most previous research has focused on the developmental trajectories for autistic spectrum disorder and attention deficit hyperactivity disorder separately, while the neural mechanisms underpinning the co-occurrence of autistic spectrum disorder and attention deficit hyperactivity disorder remain largely unknown.

Methods:

We studied 162 autistic spectrum disorder individuals (including 79 co-attention deficit hyperactivity disorder and 83 non-attention deficit hyperactivity disorder patients) and 177 typical developing individuals using resting-state functional magnetic resonance imaging data from the Autism Brain Imaging Data Exchange II, an aggregated magnetic resonance imaging dataset from 19 centers. Independent component analysis was used to extract sub-networks from the classic resting-state networks. Functional connectivity values within (intra-iFC) and between (inter-iFC) these networks were then determined. Subsequently, we compared the ASD_coADHD group with the ASD_nonADHD group in relation to the abnormal intra-iFC and inter-iFC of autistic spectrum disorder group relative to the typical developing group.

Results:

The ASD_coADHD group showed more severe social impairment and decreased intra-iFC in the bilateral posterior cingulate cortex of the default mode network (independent component 17) and increased inter-iFC between the default mode network (independent component 8) and the somatomotor networks (independent component 2) compared to the ASD_nonADHD group. In addition, the strength of the intra-iFC in the default mode network was associated with the severity of autistic traits across the entire autistic spectrum disorder group and particularly the ASD_coADHD group.

Conclusion:

Our results showed that dysfunction of the default mode network is a central feature in the co-occurrence of autistic spectrum disorder and attention deficit hyperactivity disorder, including connectivity within the default mode network as well as between the default mode network and the somatomotor networks, thus supporting the existence of a clinically combined phenotype (autistic spectrum disorder + attention deficit hyperactivity disorder).
Imprisoned But Innocent: Wrongful Convictions and Imprisonments in Germany, 1990-2016
Authors: Leuschner Fredericke , Rettenberger Martin , Dessecker Axel
Published: March 2019

Although in the United States wrongful convictions and imprisonments are a major public and scientific concern, this topic has been largely ignored in Germany for decades. The present article offers for the first time an overview of all accessible German cases of successful retrials involving convicted persons who served a prison sentence since 1990. The data refer to 31 wrongfully convicted persons in 29 independent cases. Although the largest group consists of cases of false allegations, some of the wrongly convicted were considered not guilty by reason of insanity, and a few wrongful convictions occurred because of eyewitness misidentification and false confessions. In addition, incorrect expert testimony contributed considerably to the wrongful conviction in some cases.
Relational ambivalence: Exploring the social and discursive dimensions of ambivalence—The case of Turkish aging labor migrants
Authors: Palmberger Monika
Published: March 2019

Many of Vienna’s labor migrants who entered Austria as so-called “guest workers” together with their spouses long nurtured the dream of returning to their country of origin, at the latest when they retired. By then, however, returning became less than straightforward leading to ambivalence regarding questions of belonging/return and transnational mobility and late-life care. Based on rich qualitative data, in this article, I show that ambivalences are found in the complexity of migrants’ narratives, particularly in the way they (1) reassess past choices, (2) negotiate feelings of belonging, and (3) assess future options for late life and care. I argue that the social dimension of ambivalence, which I term “relational ambivalence,” is crucial to understanding the labor migrants’ experiences, reflections, and choices. The analysis shows that ambivalence must be understood as a product of relationships rather than solely an individual experience. The concept of relational ambivalence captures these social and discursive dimensions of ambivalence. The article ultimately carves out the particularity of ambivalence in the general context of migration and in the specific context of Vienna’s labor migrants, while accepting feelings of ambivalence or the simultaneity of different, opposing positions in one and the same person as a core human experience.
Existential Depression: A Nonpathological and Philosophical-Existential Approach
Authors: Berra Lodovico
Published: March 2019

Depression is not merely an inopportune “disease.” Sometimes it is an opportunity that allows us a new and more authentic view of existence. In this sense, a philosophical-existential therapeutic approach, which considers the ultimate meanings of existence, may be more useful, efficacious, and appropriate. In existential depression, the mood is oriented in a depressive sense, at first glance in a similar way to other depressive disorders. However, it is necessary to diagnostically differentiate this sort of depressive state from others, as it requires a different type of intervention from those typically used today in treating pathological depression, such as standard psychotherapy and/or psychiatric drugs. This specific depressive condition originates from particular reflections and considerations on life, and produces a profound discomfort, highlighting how the depressive state can represent, at least in some cases, a pivotal moment of existence. In this article, the author, a psychiatrist and existential therapist, describes existential depression, its phenomenology, genesis, and philosophical-existential treatment.
Effects of Focus of Attention on Performance by Second-Year Band Students
Authors: Stambaugh Laura A.
Published: March 2019

This study tested the effect of the motor learning paradigm of internal and external focus of attention (FOA) with middle school band students. A total of 56 second-year band students (woodwinds n = 28; valved brass n = 18; trombones n = 10) practiced isochronous, alternating pitch patterns (e.g., eighth notes C–A–C–A–C–A–C) in three conditions: control (no FOA), internal (“think about your fingers”), and external (“think about your sound”). At retention testing approximately 24 hr later, students played each stimulus three times with no directed FOA. Performance trials were scored for the average duration of each pitch per trial, or evenness. No significant differences were found between conditions (control, internal, external) on Day 1 or Day 2 ( p > .05). Likewise, no significant differences were found within instrument groups from Day 1 to Day 2 ( p > .05). When evenness scores were examined at the level of the individual student, more woodwind and valved brass players benefited from the internal (fingers) FOA than from control or external conditions. Individual differences among trombone players were less pronounced, slightly favoring the external (sound) condition. Music teachers should consider implementing both internal and external FOAs with their beginning wind students.
Does segregation reduce socio-spatial mobility? Evidence from four European countries with different inequality and segregation contexts
Authors: Nieuwenhuis Jaap , Tammaru Tiit , van Ham Maarten , Hedman Lina , Manley David
Published: March 2019

The neighbourhood in which people live reflects their social class and preferences, so studying socio-spatial mobility between neighbourhood types gives insight into the openness of spatial class structures of societies and into the ability of people to leave disadvantaged neighbourhoods. In this paper we study the extent to which people move between different types of neighbourhoods by socio-economic status in different inequality and segregation contexts in four European countries: Sweden, the Netherlands, the UK (England and Wales), and Estonia. The study is based on population registers and census data for the 2001–2011 period. For England and Wales, which has long had high levels of income inequalities and high levels of socio-economic segregation, we find that levels of mobility between neighbourhood types are low and opportunities to move to more socio-economically advantaged neighbourhoods are modest. In Estonia, which used to be one of the most equal and least segregated countries in Europe, and now is one of the most unequal countries, we find high levels of mobility, but these reproduce segregation patterns and it is difficult to move to less deprived neighbourhoods for those in the most deprived neighbourhoods. In the Netherlands and Sweden, where income inequalities are the smallest, it is the easiest to move from the most deprived to less deprived neighbourhoods. The conclusion is that the combination of high levels of income inequalities and high levels of spatial segregation tend to lead to a vicious circle of segregation for low-income groups, where it is difficult to undertake upward socio-spatial mobility.
A small upland city gets a big make-over: Local responses to state ‘modernity’ plans for Lào Cai, Vietnam
Authors: Henein Youssef , Pham Thi-Thanh-Hien , Turner Sarah
Published: March 2019

Since 1986, the Socialist Republic of Vietnam has undergone tremendous upheavals in urban growth, city planning and market integration. Yet the complex transformations underway in small cities and towns, especially those in uplands regions, and their impacts on residents’ livelihoods, have been relatively ignored to date in the academic literature. Drawing on small cities and everyday politics concepts, we examine the contested relationships between a socialist state bent on completing a major urban make-over for an upland small city, and the reactions and strategies of local residents. From its historical roots as a small border trading post and colonial garrison town in the late 1800s, Lào Cai has now grown to be a key node on the Greater Mekong Sub Regions’ Eastern Corridor. Urban planning has taken a distinctively ‘modern’ turn since the early 1990s, and the contemporary city reflects a curious blend of socialist urban planning ideals, state visions of modernity and the everyday realities of the local population. Great efforts are being made by city officials and developers to copy the urban forms of Vietnam’s large low-land cities, while concurrently ignoring many of the basic needs of the local population, revealing sharp inequalities. Nonetheless, residents are subtly pushing back against the state’s plans via a range of strategies that also highlight the nuances of inhabiting a small upland city.
China’s Strategic Responses to Crises and for Rural Vitalisation
Authors: Tsui Sit , Chi Lau Kin , Wong Erebus , Tiejun Wen
Published: March 2019

The tyranny of global monopoly-finance capital can be seen in part as monetary geopolitics backed by military power. It directly appropriates, through investment schemes, production gains from the physical and resource economies of developing countries. At the same time, it engages in financial speculation by means of buying long and selling short in capital markets. The end result is the plundering of social wealth. China is not immune to this tyranny. This article analyses how China negotiates with the effects of global financial crises through adopting the policy of strategic transformation towards ecological civilisation and rural revitalisation. In addition, the grassroots initiative of rural reconstruction movement has played an important role in the ongoing transformative process.
Using a Multiple-Schedule Procedure to Signal the Availability of Attention: Three Demonstrations
Authors: Niedfeld Amanda , Rapp John T. , Coon Jodi C. , Cook Jennifer L.
Published: March 2019

Adjudicated adolescents detained in residential facilities for illegal sexual behavior, as well as adolescents living at home, may engage in problem behaviors such as excessive vocalizations. In residential detention facilities, these excessive vocalizations may result in disciplinary action and loss of privileges. Moreover, excessive vocalizations may also reduce the amount of positive social interactions that staff members and caregivers have with the adolescents. The current study evaluated a multiple-schedule procedure for reducing excessive vocalizations displayed by three adolescents. The procedure involved (a) a red card to signal that attention was not available and (b) either a green card or no card to signal that attention was available. Results show that the participants learned to abstain from vocalizing for up to 30 min when a caregiver presented the red card. In addition, the treatment effects persisted during generalization assessment sessions.
Broken promises of Internet and democracy: Internet art in Serbia, 1996–2014
Authors: Mihaljinac Nina , Mevorah Vera
Published: March 2019

The article uses case studies of artistic and cultural practices on Internet in Serbia (1996–2014) to provide a deeper analysis of possible uses of internet technology and internet art for social and political change as well as showcasing changing attitudes toward the internet in a transitional semi-periphery state. Through analyzing these questions, the article defines several phases of development of internet and art projects in Serbia including (a) the phase of techno-utopia when internet technology was used for staging and supporting student protests and the so-called first ‘internet revolution’ in Serbia (1996–1999); (b) the phase of ambivalence or ‘mixed feelings’ toward the Internet, triggered of by Kosovo War and North Atlantic Treaty Organization (NATO)-led bombing of 1999–2000; (c) the phase of optimism and hope about the Internet after the ‘October 5th’ revolution (2000–cc. 2005); and (d) the phase of disillusionment with both the Internet and democracy (2010–2014). This study re-evaluates early achievements and democratic principles of networked society and illuminates core issues and accomplishments of cyberculture from the 1990s until present times through the point of view of multiple actors present within Serbian art and culture.
How algorithms see their audience: media epistemes and the changing conception of the individual
Authors: Fisher Eran , Mehozay Yoav
Published: March 2019

The rise of digital media has witnessed a paradigmatic shift in the way that media outlets conceptualize and classify their audience. Whereas during the era of mass media, ‘seeing’ the audience was based on a scientific episteme combining social theory and empirical research, with digital media ‘seeing’ the audience has come to be dominated by a new episteme, based on big data and algorithms. This article argues that the algorithmic episteme does not see the audience more accurately, but differently. Whereas the scientific episteme upheld an ascriptive conception which assigned individuals to a particular social category, the algorithmic episteme assumes a performative individual, based on behavioral data, sidestepping any need for a theory of the self. Since the way in which the media see their audience is constitutive, we suggest that the algorithmic episteme represents a new way to think about human beings.
Partner Support as a Protection Against Distress During the Transition to Parenthood
Authors: Gillis Aurélie , Gabriel Barbara , Galdiolo Sarah , Roskam Isabelle
Published: March 2019

The majority of previous studies focused on mothers’ distress and considered partner support from the father to the mother. The current research studies the level and the course of distress and partner support in new mothers and fathers during the transition to parenthood and tests the protective role of partner support against distress. Data were collected in a two-wave longitudinal design from 53 heterosexual couples. Mothers and fathers completed questionnaires at two measurement occasions, that is, in the third trimester of pregnancy and 3 months after childbirth. The results provided arguments in favor of a dyadic perspective on distress during the transition to parenthood. No difference was displayed between mothers and fathers before and after childbirth. The level of distress decreased in mothers and also in fathers but only for those whose partner’s distress also decreased. The importance of partner support against postpartum distress was highlighted for mothers and fathers.
Ignoring Respect: The Effects of Threat to Face on Replies and the Ensuing Questions During Broadcast Political Interviews in Japan
Authors: Feldman Ofer , Kinoshita Ken
Published: March 2019

This article examines the effect of threat to face to both interviewers and interviewees during live televised interview programs in Japan, where the concept of “face” is of extreme importance in maintaining interpersonal relationships. Based on 2,422 questions identified during 120 interviews broadcast over a period of 12 months on four television programs, the goal is twofold: First, to assess the extent to which questions that contain a certain level of threat to face affect the interviewees’ replies, and second, to measure the extent to which interviewees’ replies affect the interviewers’ subsequent questions. The findings indicate that questions containing a higher degree of threat to the interviewers’ face resulted in less clear and comprehensible replies. Furthermore, equivocal responses to questions increased the chance of a follow-up question being more face-threatening, suggesting that interviewers who are unsatisfied with the replies of their interviewees manifest their displeasure with tougher follow-up questions.