bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluación de algoritmos de clasificación para la identificación de la deforestación en el resguardo indígena Llanos del Yarí Yaguara II
Authors: Cumbe Loaiza Laura Camila , Guerrero Varona Luis Miguel , Medina Daza Rubén Javier
Published: February 2025

La deforestación se ha convertido en un problema crítico en muchas regiones del mundo, particularmente en áreas de alto valor ambiental y cultural, como el resguardo indígena Llanos del Yarí Yaguara II. Comprender el alcance e impacto de la deforestación en este resguardo requiere un enfoque metodológico sólido para analizar de manera efectiva los cambios en la cobertura del suelo. Este artículo analiza diferentes algoritmos de clasificación para determinar cuál ofrece mayor fiabilidad en la identificación de cambios en la cobertura debido a la deforestación, en combinación con el conocimiento de la zona y la cartografía de los cambios en el uso y cobertura del suelo. Se utiliza la teledetección, una herramienta ampliamente empleada para este propósito, que aplica dos algoritmos de clasificación no supervisada y cinco algoritmos de clasificación supervisada con datos de dos imágenes satelitales, Landsat 8 y Landsat 9. Se analiza la clasificación de imágenes satelitales en el resguardo indígena, revelando una baja precisión en los algoritmos de clasificación no supervisada. En contraste, los algoritmos supervisados, en particular la Máquina de Soporte Vectorial y la Distancia Mahalanobis, logran una precisión del 97 %, apoyando de manera efectiva la identificación de áreas deforestadas. La aplicación del método de Máxima Verosimilitud en ArcGIS para el análisis multitemporal confirma la drástica disminución de las áreas clasificadas como vegetación abundante. Además, se destaca la significativa pérdida de bosque denso en el resguardo durante seis años, lo que subraya la urgencia de acciones coordinadas para prevenir más daños ecológicos y sociales. Los resultados de este estudio recalcan la importancia de utilizar algoritmos de clasificación supervisada para la cartografía de alta precisión de la deforestación, y proporcionan una base confiable para la gestión ambiental y la toma de decisiones políticas en territorios indígenas.
El conocimiento de las aplicaciones de IA para gestionar procesos en los negocios
Authors: Zúñiga Alvarado María Alejandra , Zea Villacís Norma Margarita , Méndez Medrano Cristian Gilberto
Published: February 2025

En un mundo cada vez más digitalizado, la inteligencia artificial (IA) se ha convertido en una herramienta indispensable para las empresas que quieren optimizar sus procesos para mejorar la eficiencia y tomar decisiones oportunas. Esta investigación tiene como objetivo determinar cómo el conocimiento de las aplicaciones de IA contribuye a la gestión de procesos en los negocios. Para este estudio, se utilizó una metodología de tipo empírico, usando como instrumento para la obtención de datos una encuesta que se aplicó de forma aleatoria a 385 negocios de la ciudad de Guayaquil, Ecuador. En la encuesta se consultó sobre el conocimiento de las aplicaciones IA y de qué forma estas han contribuido con la gestión de procesos en los negocios; los datos obtenidos fueron de tipo cuantitativo y cualitativo. En el estudio desarrollado se determinó que varios negocios están utilizando aplicaciones de IA para actividades de gestión, principalmente para la generación de mensajes personalizados y de contenidos en las redes sociales; en menor proporción para la creación del nombre, logo y eslogan de los negocios; en términos generales estas aplicaciones han contribuido a optimizar la comunicación con los clientes, incrementar la popularidad de los negocios y mejorar los niveles de rentabilidad. Cabe recalcar que existe un grupo considerable de negocios que requiere mayores conocimientos técnicos en lo referente a las aplicaciones de inteligencia artificial (IA), para emplearlas en la gestión de procesos en sus negocios. En conclusión, en este estudio se determinó que varios negocios utilizan la inteligencia artificial de forma incipiente, pero desean obtener mayores conocimientos sobre las aplicaciones de esta poderosa herramienta que está revolucionando todos los ámbitos.
Financial technology: The catalyst for BRICS' economic and financial leap
Authors: M Dhaya , N Sundaram
Published: February 2025

This research attempts to ascertain how fintech contributes to the financial development and economic expansion of the BRICS nations. Samples were gathered between 2002 and 2021 using panel data analysis with fixed effects as the research approach. OLS regression was used for analysis. Variables are collected from World Development Indicators and data analysis is done using Gretl software.  Three hypotheses are put out in the study and are validated based on the data collected. As per the first hypothesis, fintech is having a beneficial impact on the GDP which is used as a gauge for the nation's economic growth. A second hypothesis posits that fintech impacts the overall money supply which serves as a gauge for financial progress. The third hypothesis states that fintech impacts bank deposits relative to GDP; the second metric chosen to measure financial development is not favorable according to the results. The impact of fintech on financial development and economic growth shows positive impacts. Fintech can enhance the overall economic growth of emerging economies. Maximum utilization of upcoming technology can result in financial development. Emerging economies can benefit from the use of financial technologies to further their financial and economic development. The analysis highlights how crucial technology is to the financial industry.
Empirical analysis of adaptive market hypothesis using Sharpe Ratio for buy and sell opportunities in global indices
Authors: Raju Ajay , Jagannathan Uday Kumar , Pundalika Triveni
Published: February 2025

This study aims to investigate market efficiency and compare the profitability of the Sharpe Ratio Minimae and Maximae trading strategies with the buy-and-hold strategy across indices in different global markets. It tests the prevalence of the Adaptive Market Hypothesis (AMH) by analyzing cyclical variations in strategy performance. The research covers stock indices from six countries, analyzing monthly data spanning January 1998 to December 2023. A rolling window approach is adopted to evaluate time-varying performance and explore potential correlations with market inefficiency. Statistical tests are employed to examine the dynamics of the Sharpe Ratio and its role in investment decision-making and risk assessment. The findings reveal that the Sharpe Ratio Minimae and Maximae strategies consistently outperformed the buy-and-hold strategy across all indices. These strategies achieved higher returns per unit of risk, validating the Adaptive Market Hypothesis by highlighting cyclical variations in market profitability. The results confirm the superior performance of Sharpe Ratio-based strategies over the buy-and-hold approach, supporting the presence of evolving market efficiency in line with the Adaptive Market Hypothesis. The study provides actionable insights for investors and portfolio managers, emphasizing the importance of recognizing market inefficiencies and adopting adaptive strategies. Adjusting investment approaches based on changing market conditions can significantly improve risk-adjusted returns.
How Does the Impact of Political and Economic Risks Affect Foreign Investment in ASEAN-7
Authors: Idialis Alifah Rokhmah , Anggraini Riesta Firsty
Published: February 2025

Unstable economic and political conditions can increase uncertainty and potential foreign investment losses. According to Marsh (2019), ASEAN-7 countries (Indonesia, Myanmar, Vietnam, Thailand, Malaysia, Philippines, and Cambodia) have high and medium economic and political risks in ASEAN. An in-depth analysis of foreign investment that is assumed to be correlated with economic and political risk is required. The research methodology used is the Panel Corrected Standard Error (PCSE) as the analysis technique. The results show that economic risk with trade openness indicator positively and significantly affects foreign direct investment. This means that when ASEAN-7 countries have the ability to increase their international trade activities, the flow of FDI will increase. Political risk with political stability indicator has a positive and significant effect on Foreign Direct Investment. This means that good political stability conditions in ASEAN-7 will increase FDI flows to ASEAN-7 countries. The corruption perception index negatively and significantly affects the foreign direct investment. This means that the more corrupt the countries in ASEAN-7, the higher the FDI flow to ASEAN-7 countries.
Productivity of Siwalan Farmers in Madura (Past and Now): A Demographic Analysis
Authors: Kristina Anita , Jumali Muhamad Abdul
Published: February 2025

This study aims to analyze the productivity of siwalan farmers engaged in the production of brown sugar in Aeng Panas village, Madura, Indonesia. The analysis is conducted from social, historical, production, and demographic perspectives. The study seeks to reconstruct the productivity of Siwalan farmers through demographic analysis, highlighting the challenges posed by changes in the agricultural work environment over time, considering that the brown sugar business has been a part of their heritage. The method used is rapid ethnography, incorporating data collected through interviews. The study reveals that changes and expansion of land areas or the adoption of modern work safety technology do not influence the productivity of palm sugar farmers in brown sugar production. Instead, the productivity value is shaped by the labor structure pattern, the working class hierarchy, and the patriarchal mindset, which have undergone minimal changes over time. The findings of this study contribute to the understanding that productivity in this context is largely influenced by labor demographics, specifically the social patterns within the farmer’s work environment.
The Application of Cleaner Production of Batik Industry (Case of Pamekasan Regency, East Java, Indonesia)
Authors: Vibriyanto Norita , Titik Crisanty S , Hoirina Arabela Sulfa
Published: February 2025

Batik is a representation of the cultural identity that is produced and offers insight into the daily lives of those who create it. It has a positive impact on economic development in Indonesia, such as increased income and reduced unemployment. Therefore it is important to manage and maintain Indonesia’s batik crafts. In the current era of globalization, there is awareness of the importance of sustainable development. It is crucial that all parties engage in initiatives aimed at achieving sustainable development such as the implementation of cleaner production practices. Cleaner production represents a proactive strategic program that is implemented with the objective of aligning sustainable economic development activities with environmental protection efforts. The objective of this study was to ascertain cleaner production in the batik industry with regard to sustainable development. This research used a qualitative methodology by triangulation to validate the data obtained from informants. The findings indicated that the batik production in Pamekasan never fully adopted the principle of cleaner production. This is because artisan Batik in Pamekasan considers that synthetic dyes are more profitable for the production of batik products and affordable for consumers.
Convention No.190 on Combating Violence and Harassment at Work
Authors: Larion Alina
Published: February 2025

In 2015, the governing bodies of the ILO decided that they needed to adopt a legal instrument providing everyone's right to a world of work free from violence and harassment, including gender-based harassment. Therefore, at the International Labor Conference, Convention No. 190 was adopted, accompanied by Recommendation No. 206. The aim of these normative acts is to prevent and eliminate violence and harassment at work. We believe that it is useful and necessary to carry out an analysis highlighting, in a broader context, the issue of prevention and elimination of violence and harassment at work.
Aspects regarding Public Administration and Diplomacy of Iceland
Authors: Nedelea Oana
Published: February 2025

Public administration in Iceland has several unique characteristics and peculiarities that are related to small scale governance, high level of trust, decentralization and local autonomy, integration of digital technology, environmental focus, cultural influence, gender equality, resilience and crisis management, international cooperation. Icelandic diplomats focus on areas where the country can have a significant impact, such as environmental advocacy, human rights, and multilateral cooperation. Iceland's diplomacy is shaped by its unique geographical location, small population, and historical and cultural context. As a small island nation in the North Atlantic, Iceland has developed a distinctive approach to international relations that emphasizes neutrality, multilateralism, and environmental advocacy.
The Social Interest Involved in Ensuring that the Private Limited Company Operates Properly
Authors: Leuciuc Eugenia Gabriela
Published: February 2025

Social interest is not to be confused with the sum of the interests of the members, but summarizes the converging interests of the various categories of participants in the life of the company, both those of the members, as well as the interests of the administrators, auditors, employees, business partners, customers, etc. The refore, the social interest becomes one of the most important criteria for assessing the activity of the statutory bodies, especially the operations of administration and representation of the limited liability company in relations with third parties. The conformity of the full management operationswith the social interest is analyzed from the point of view of their usefulness, necessity and appropriateness for the company, otherwise the liability of the administrators may be engaged. At the same time, the social interest underlies the principle of the good manager, the "prudent business man" and diligent, who in making business decisions acts honestly and loyally to achieve the purpose of the limited liability company. The use of this standard also within the limited liability company enables the partners to ensure that the directors have sufficient freedom of action in carrying out management operations, avoiding the company's involvement in risky operations. As a result, the complexity of the limited liability company's activity requires more rigorous regulation of the function of administrator, the rule referring to the legal regime for administrators of partnerships being insufficient and the prohibition on the application of the rules on the administration of public limited companies being totally inadequate. In this regard, we are prepared to make a number of proposals by law ferenda in this article.
Medialaby. Nowe laboratoria humanistyki cyfrowej w Polsce
Authors: Sołtysiak Daniel
Published: February 2025

W artykule przedstawione zostaną teoretyczne konteksty funkcjonowania medialabów: przemiany i poszukiwania współczesnej humanistyki oraz założenia paradygmatu cyfrowej humanistyki. W polskim kontekście istotne są źródła inspiracji zachodnimi instytucjami (MIT MediaLab) oraz prekursorskie inicjatywy (Medialab Chrzelice) rozpoczynające szeroki dyskurs wśród akademików. Perspektywa historyczna odnosi się do idei DIY (Do It Yourself), której mocne zakorzenienie w polskiej kulturze odnaleźć można w sytuacji gospodarczej PRL-u w latach 80. oraz procesach oddolnej komputeryzacji kraju (giełdy komputerowe, samodzielne modyfikowanie i serwisowanie mikrokomputerów). Medialaby stanowią interdyscyplinarne instytucje o różnych kierunkach działalności – edukacyjnym, badawczym, społecznym etc. Obecny w logice funkcjonowania medialabów model pracy laboratoryjnej opiera się na kilku podstawowych wyznacznikach: ahierarchiczności, interdyscyplinarności, otwartości, zespołowości, procesualności oraz kreatywności. Druga część artykułu poświęcona będzie założeniom oraz metodologii moich badań dotyczących polskich medialabów, oraz dotychczas poczynionym obserwacjom. Celem projektu jest zbadanie obecnej kondycji polskich medialabów (Medialab Katowice, Medialab Gdańsk, UBU lab w Krakowie), poznanie wypracowanych w nich metod pracy oraz kierunków podejmowanych działań. Stanowią one ważne źródło rzeczywistej, praktycznej przemiany modelu pracy humanisty. Projekt ukaże więc jak postulat reintytucjonalizacji humanistyki oraz wdrażania w praktyce aksjomatów humanistyki cyfrowej rozwija się na gruncie polskim. Jednocześnie badania uwzględnią wpływ pandemii COVID-19 na obecną kondycję i funkcjonowanie medialabów.
Władysław Bieńkowski – krytyk „realnego socjalizmu” (1906-1991)
Authors: Kapica Bartłomiej
Published: February 2025

Zapalczywy, ugnieciony jakby z siarki i saletry, duch wiecznej Negacji w ciele satyra (był ogromnie brzydki, ale tą typową brzydotą, o której się mówi, że jest „fascynująca”). Wolność była dla niego bogiem. Najulubieńszym fragmentem Żeromskiego był dla niego monolog Czarowica „Puśćcie mnie kraty…” […]. Bieńkowskiego mi szczerze żal, bo wiem, jaki jest zdolny, wiem, jaki żywy, godny Odrodzenia, umysł się zmarnował.
J. Kowalewski, Gdy ministrowie byli wywrotowcami [cz. II], „Kultura” 1949, nr 9/26, s. 132
Obecnie Władysława Bieńkowskiego, poza historykami zajmującymi się PRL, nikt nie kojarzy. Najczęściej w opisie jego działalności podaje się, że był ministrem oświaty oraz współpracownikiem Władysława Gomułki. W pełnym paradoksów życiu Bieńkowskiego zawiera się jednak przede wszystkim opowieść o dwudziestowiecznej historii Polski. Z jakich powodów wspierał nauczanie religii w PRL-owskich szkołach? Czy jako komunista mógł być krytykiem komunizmu w Polsce? Dlaczego wreszcie były współpracownik Gomułki wspierał opozycję demokratyczną?
Projekt został sfinansowany ze środków Narodowego Centrum Nauki przyznanych na podstawie decyzji nr UMO-2016/20/S/HS3/00311
Ultrasonographic Features of the Prostate Gland in Dogs in Jaipur, Rajasthan
Authors: Sewag Anita , Bargujar Jitendra , Singh Rashmi , Jeph N.K. , Meena Amit Kumar , Choudhary Akanksha , . Ankita
Published: February 2025

Background: Prostate gland ultrasonography is a diagnostic imaging technique used to assess size, shape and structure of the prostate gland in male dogs. Prostate size estimation is important in the diagnosis and monitoring of prostatic disorders such as prostatitis, benign prostatic hyperplasia (BPH), cysts, abscesses and neoplasms. Methods: The dimensions of prostate gland in dogs, as assessed by ultrasonography, is currently not yet reported in this area.This study was aimed at reporting of standardization of prostate gland features including length, width and ultrasonographic appearance and correlation of prostate gland parameters i.e. length and width with age and body weight of healthy dogs, 2-5 years old of German shepherd (n=30) and Labrador (n=30) breeds, reported at Veterinary Clinical Complex of Post Graduate Institute of Veterinary Education and Research (PGIVER), Jaipur. B-mode transabdominal ultrasonographic examination was done at 6 MHz frequency in lateral recumbency without sedation. Result: Prostate gland had hypoechoic homogenous parenchyma with moderately echogenic stippling appearance. The capsule appeared relatively hyperechogenic. In GSD age group-I (2 to 3 years), group-II (3 to 4 years) and group-III (4 to 5 years) prostate measured 22.73±1.01 mm and 22.58±0.95 mm; 30.22±1.85 mm and 29.04±1.66 mm and 32.02±0.65 mm and 32.34±0.90 mm in length and width, respectively. In Labrador age group-I (2 to 3 years), group-II (3 to 4 years) and group III (4 to 5 years) prostate measured 20.88±0.62 mm and 22.32±0.67 mm; 26.54±0.56 mm and 27.97±0.63 mm and 37.05±0.90 mm and 37.90±1.12 mm in length and width, respectively. Prostatic parameters i.e. length and width in GSD and Labrador (in all three groups) showed positive correlation with age and body weight. Ultrasonographic features of the prostate are considered to be more precise, as gives clearly distinct demarcation of the prostate’s edges with better resolution and visualization along with absence of a magnification effect.
Analysis of Secondary Metabolites (SMs) in Ochradenus baccatus Collected from Riyadh, Saudi Arabia and its Potential Preventive Role on Coccidia that Infect Rabbits
Authors: Aljawdah Hossam M. , Murshed Mutee , Ammari Aiman A. , Maodaa Saleh N , Al-Quraishy Saleh
Published: February 2025

Background: The increasing focus on medicinal and aromatic plants is due to their secondary metabolites (SMs), which offer a feasible alternative to synthetic pharmaceuticals. O. baccatus has been historically employed in folk medicine for its anti-inflammatory and antibacterial properties. Rabbits serve as a protein source and contribute to ecological balance. Methods: A study was performed on the phytochemical composition of the extract from O. baccatus. The antioxidant activity of O. baccatus extract was assessed in vitro using ABTS assays and the IC50 values were determined. The antiparasitic activity in vitro was evaluated using five distinct concentrations of O. baccatus extract. The extract’s inhibition of sporulated oocysts was evaluated after 72 hours. Result: The FT-IR analysis of the C. spinosa extract revealed the presence of 12 distinct compounds. The GC-MS analysis identified approximately 11 primary biologically active compounds. The extract exhibited significant antioxidant properties, with inhibition rates varying from 93.655% to 17.255% across concentrations of 500 to 15.625 μg/mL. The IC50 value was determined to be 147.032 μg/mL. The antiparasitic effects were evaluated in vitro, revealing that oocysts exhibited the highest level of inhibition at concentrations of 50 mg/mL and 25 mg/mL.
Editorial
Authors: Suárez-Giraldo Cristian
Published: February 2025

La experimentación literaria en el campo de las humanidades digitales y en la época de la inteligencia artificial (IA) ofrece, para la práctica y para la crítica, horizontes de discusión e investigación que renuevan nuestras ideas, teorías y concepciones sobre la obra literaria misma y los mecanismos de transmisión de la palabra escrita, así como de la historia y la tradición en que se ha inscrito. En la era de la información, preguntarse por el lenguaje generativo, el uso de ChatGPT, la creación asistida, las humanidades, la edición, los estudios culturales y las artes, no solo representa una postura de vanguardia; es la manera en que nos enfrentamos a nuestra cultura.
PRIMARY-HF: Heart Failure Screening in Primary Care using Point-of-Care
Authors: Dos Santos Jonathan , Nobre João Pedro , Ferreira João Pedro , M. Marques Maria Inês , Henriques Miguel , Cardim Nuno , Villanueva Tiago , Gonçalves Alexandra
Published: February 2025

Introduction: Heart failure is a major health challenge with high morbidity and socioeconomic burden, especially when diagnosis is delayed. In primary care, HF detection can be challenging due to symptoms overlapping with other conditions, limited access to diagnostic tools, and resource constraints. This study explores the use of natriuretic peptides (NT-proBNP) and point-of-care ultrasound (POCUS) with artificial intelligence integration as tools to improve HF screening and management in primary care. This study aims to determine whether NT-proBNP testing alone or combined with cardiac POCUS improves heart failure diagnosis and management in primary care settings, and to evaluate the cost-effectiveness of this approach.Methods: This randomized controlled trial will involve patients aged 50 or older with suspected HF or cardiovascular risk factors, recruited across four primary care centers. Participants will be randomly assigned to one of four groups: standard of care (SoC), SoC with NT-proBNP, SoC with NT-proBNP and POCUS, and SoC with POCUS. Primary outcomes include new HF diagnosis, initiation of guideline-directed medical therapy, and improvement in health-related quality of life. Secondary outcomes include cost-effectiveness and the quality assessment of POCUS performed by trained primary care physicians. The integration of NT-proBNP and POCUS in primary care may enhance early heart failure diagnosis, optimize therapy, improve patient quality of life, and reduce healthcare costs associated with heart failure misdiagnosis and delayed treatment. This study could support the broader adoption of accessible diagnostic tools to improve heart failure management in primary care.
Evaluation of Antimicrobial and Antioxidant in Acalypha fruticosa Leaves: A Natural Source of Bioactive Compounds
Authors: Alabyadh Mokhtar , Sharaf Hasan , Mazen Rania , Saeed Adel , Al-salmi Mokhtar , Masood Nasser , Nagy Hatem , Abdulhakeem Rana , Saleem Ismail , Abdulrhman Mohammed , Maher Mohammed , Abdullah Sultan , Ali Waheed , Naji Taha
Published: February 2025

Acalypha fruticosa is a medicinal plant widely used in traditional medicine for treating various ailments. This study aimed to investigate the phytochemical constituents, antibacterial, and antioxidant properties of the leaves of this plant. We extracted the leaves of A. fruticosa using methanol, diethyl ether, and water solvents. Qualitative phytochemical screening was performed to detect the presence of different phytochemicals. The well diffusion method was used to test the antibacterial activity against Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus aureus, and Escherichia coli. Antioxidant activity was assessed qualitatively by TLC bioautography and quantitatively by DPPH radical scavenging assay, using ascorbic acid as a positive control. Phytochemical screening revealed the presence of various phytochemicals, including alkaloids, flavonoids, saponins, terpenes, tannins, phenols, glycosides, carbohydrates, and proteins, while steroids were absent. The aqueous extract showed maximum inhibition zones against P. aeruginosa and E. coli (17 mm each), while the diethyl ether extract exhibited the highest inhibition against S. aureus (33 mm). The methanolic extract only showed activity against P. aeruginosa (16 mm). All extracts were ineffective against K. pneumoniae. Qualitative antioxidant assessment by TLC demonstrated the presence of antioxidant compounds in all extracts. The quantitative DPPH radical scavenging assay indicated that the methanolic extract had the highest antioxidant activity compared to the other extracts and ascorbic acid. The findings suggest that A. fruticosa leaves are a rich source of phytochemicals and possess significant antibacterial and antioxidant properties, supporting their potential use in the development of natural therapeutic agents.
Criação sustentável de ovinos no Pantanal: uma revisão sistemática da literatura
Authors: Bitencourt Taner Douglas Alves , Facco Gilberto Gonçalves , Dos Reis Neto José Francisco , Matias Rosemary
Published: February 2025

O objetivo deste artigo foi proceder a uma revisão sistemática de produção acadêmica e padrões na literatura sobre sistemas de criação de ovinos rentáveis financeiramente e com práticas de sustentabilidade econômica, social e ambiental nos biomas em que são desenvolvidos. Utilizou-se a técnica de estruturação em população, desfecho e tipo de estudo para definir a pergunta, seguida de busca, extração e seleção de artigos por meio da análise pareada. Percebeu-se uma evolução temática nas abordagens em quatro períodos analisados. Identificaram-se publicações relevantes em citações de criação sustentável de ovinos, com destaque para a Europa, Austrália e o Brasil. Não foi selecionado estudo que descreva criação sustentável de ovinos no Pantanal. Atualmente, o foco da produção permanece na lucratividade, porém os impactos ecológicos e sociais ganham protagonismo, e criações com raças locais e ameaçadas de extinção surgem como possibilidade para o desenvolvimento de cadeias produtivas sustentáveis que fortaleçam a economia local.
The Foreign Subsidies Regulation
Authors: Afilipoaie Adelaida
Published: February 2025

Complaints regarding the distortive and unregulated competitive effects of foreign investors sponsored through foreign state subsidies investing in Europe through mergers and acquisitions, public procurement, and greenfield projects, have led to the creation of the Foreign Subsidies Regulation (FSR). Through the FSR, subsidies granted by non-EU governments can be reviewed by the European Commission. The FSR signals a more cautious, protectionist approach to foreign investments in critical sectors to which media and telecom belong. Through a comparison of select procedural provisions, this article situates the FSR among two other ex-ante regulations, the Foreign Direct Investment Regulation, and the EU Merger Regulation, revealing its striking commonalities with the latter. Media concentration and covert foreign subsidies exceed competition-related concerns to include risks to media capture and foreign interference. While focusing on addressing competition-related market distortions, the FSR plays an unexpected role in the European Media Freedom Act, which addresses the risks of financially state-controlled ‘rogue media service providers’.
The effectiveness of dietary fiber in inflammatory bowel disease
Authors:   Research Clinical Institute of Childhood, Moscow, Russian Federation, Khavkin A.I. ,   Belgorod State National Research University, Belgorod, Russian Federation, Nalyotov A.V. ,   M.Gorky Donetsk State Medical University, Donetsk, Russian Federation, Shumilov P.V. ,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation, Sitkin S.I. ,   Almazov National Medical Research Centre, Saint Petersburg, Russian Federation,   I.I.Mechnikov North-Western State Medical University, Saint Petersburg, Russian Federation,   Institute of Experimental Medicine, Saint Petersburg, Russian Federation
Published: February 2025

The gut microbiome plays a fundamental role in maintaining human health and the development of a number of diseases. A change in the number of bacteria metabolizing indigestible dietary fibers is considered as a link in the pathogenesis of inflammatory bowel disease. A growing body of evidence supports the benefits of dietary fiber in maintaining the composition of the intestinal microbiome and its effect on intestinal health. Some fermentable fibers are metabolized by intestinal bacteria to short-chain fatty acids (acetate, butyrate and propionate), which have immunomodulatory properties, promote regeneration of the intestinal epithelium, lower the pH of the colon and inhibit the growth of pathogenic microorganisms. The article presents up-to-date information on the mechanisms of action of dietary fibers on the intestinal mucosa and on the
effectiveness of the use of different types of dietary fiber in patients with inflammatory bowel disease.
Key words: dietary fiber, prebiotics, inflammatory bowel disease, microbiota, short-chain fatty acids, butyrate
Asociación entre el soporte social y el fenotipo frágil depresivo en adultos mayores del distrito de Totos, 2022
Authors:   , Piscoche Espejo Maria Fernanda , Ramirez Videla Zareli
Published: February 2025

Objetivo: Estimar la asociación entre el soporte social y el fenotipo frágil depresivo en adultos mayores del distrito de Totos 2022.
Materiales y métodos: Realizamos un análisis secundario de datos de un estudio transversal en adultos mayores (60 años o más) del distrito de Totos, Ayacucho, Perú, en 2017. La fragilidad se definió según el fenotipo de Fried, con tres o más de los siguientes criterios: pérdida de peso, agotamiento, lentitud, sedentarismo y debilidad muscular. La depresión se evaluó con la Escala de Depresión Geriátrica (GDS), considerando síntomas depresivos con un puntaje ≥ 2. El fenotipo frágil depresivo se definió como la coexistencia de ambos síndromes. Se recopilaron datos sociodemográficos, comorbilidades, hábitos nocivos, apoyo social y evaluación funcional, incluyendo incontinencia urinaria. Utilizamos modelos de regresión de Poisson crudos y ajustados para estimar la asociación entre apoyo social y fenotipo frágil depresivo, calculando razones de prevalencia (RP) con intervalos de confianza al 95%. El análisis se realizó con STATA V.16 y recibió aprobación ética del Comité de Ética de la Universidad Científica del Sur.
Resultados: Se analizó una muestra de 272 adultos mayores de un distrito altoandino, con una edad promedio de 75 años. Se encontró que las mujeres (55,5%) y los mayores de 80 años (56,2%) presentaron mayor prevalencia del fenotipo frágil depresivo, con asociaciones estadísticamente significativas. En cambio, no se hallaron asociaciones significativas con el estado civil, vivir solo, el trabajo, tabaco, comorbilidades o polimedicación.
El consumo de alcohol (81,5%) y hoja de coca (66,7%) estuvo asociado con una mayor prevalencia de fragilidad depresiva, al igual que los trastornos neurocognitivos (53,8%) y los síntomas depresivos (82,7%)...
Semantic Drawn Robot Language : a method to extract robotic programs from physically drawn symbols
Authors: pedersen jens , Sieder-Semlitsch Jakob
Published: February 2025

This paper builds on top of existing research that have developed methods and software to instruct industrial robot arms through physical drawings made on work-pieces. Previous research has presented two principal findings: 1) a calibration and implementation method for a visual system that isolates drawings, creates a digital twin, and allows operators to augment it with fabrication information through a software. And 2) a symbol training pipeline, where symbols can be digitally drawn, labelled, stored in a database, and used to train a Machine Learning pipeline to classify physical drawings. In building on top of these findings, this research presents a method to convert physically drawn symbols by using computer vision algorithms and kMeans clustering to convert them into robotic fabrication instructions. The method consists of two computational layers, where images are first segmented and classified, before geometric information is extracted and converted into robotic fabrication sequences. The developed method is demonstrated through the manufacturing of a wall section using a full-scale robotic setup, consisting of an ABB IRB 6620, equipped with a webcam and 5.6 KW spindle with a 20 mm routing bit.
How uncertainties could affect the establishment of tumour control probability profiles in radiopharmaceutical therapy?
Authors: Dieudonné Arnaud
Published: February 2025

Purpose
This study examines the impact of uncertainties in absorbed dose and response evaluations on establishing tumour control probability (TCP) profiles in radiopharmaceutical therapy (RPT).
Methods
Using three simulated TCP models with varying slopes (γ50), the impact of uncertainties of up to 30% in absorbed dose and response classification errors were studied. Logistic regressions on 100 simulated datasets assessed the accuracy of TCP parameters.
Results
The results show that dose uncertainties significantly affect TCP models but can be mitigated by increasing the sample size. Errors in response classification have a smaller impact. Parameters like x50 (dose for 50% tumour control) were more accurately predicted than γ50 (radiosensitivity). Accuracy improves notably when sample sizes exceed 300 and dose uncertainties remain below 15%.
Conclusion
The findings highlight the importance of estimating uncertainties and increasing sample size to improve TCP model reliability in clinical studies.
MCL-1 as a molecular switch between myofibroblastic and pro-angiogenic features of breast cancer- associated fibroblasts
Authors: Souazé Frédérique , Lefebvre Chloé , Giowachini Philippine , Derrien Jennifer , Naour Maxime , Corre Isabelle , Douillard Elise , Guillonneau François , Campone Mario , Juin Philippe
Published: February 2025

Breast cancer-associated fibroblasts (bCAFs) comprise inflammatory CAFs (iCAFs), characterized by the secretion of pro-inflammatory cytokines, and myofibroblastic CAFs (myCAFs), distinguished by their high production of extracellular matrix and their immunosuppressive properties. We previously showed that targeting the anti-apoptotic protein MCL-1 in primary culture of bCAF derived directly from human samples reduces their myofibroblastic characteristics. We herein show by single-cell RNA-sequencing analysis of bCAFs that MCL-1 knock down induces a phenotypic shift from wound-myCAF to IL-iCAF, characterized by the upregulation of genes associated with inflammation as well as angiogenesis-related genes. In vitro, genetic and pharmacologic MCL-1 inhibition increases VEGF secretion by bCAFs, enhancing endothelial cell tubulogenesis. In a chicken chorioallantoic membrane (CAM) model in ovo, co-engraftment of breast cancer cells and bCAFs with reduced MCL-1 expression leads to heightened peritumoral vascular density, driven by VEGF. Mechanistically, the pro-angiogenic phenotype revealed by MCL-1 inhibition is dependent on BAX-BAK activity. It results in NF-κB activation, inhibition of which by a IKKβ inhibitor suppresses the transcription of VEGF and pro-inflammatory factors triggered by MCL-1 inhibition in bCAFs. Chemotherapy induces a downregulation of MCL-1 in bCAFs and it promotes a pro-angiogenic phenotype, counteracted by overexpressed MCL-1. Overall, these findings uncover a novel regulatory function of MCL-1 in determining bCAF subpopulation differentiation and highlight its role in modulating their pro-angiogenic properties, in response to treatment in particular.
Machine learning models for predicting medium-term heart failure prognosis: Discrimination and calibration analyses
Authors: Nishino Takuya , Kato Katsuhito , Tara Shuhei , Hayashi Daisuke , Seki Tomohisa , Takiguchi Toru , Kubota Yoshiaki , Yamamoto Takeshi , Maruyama Mitsunori , Kodani Eitaro , Kobayashi Nobuaki , Shirakabe Akihiro , Otsuka Toshiaki , Yokobori Shoji , Kondo Yukihiro , Asai Kuniya
Published: February 2025

The number of patients with heart failure (HF) is increasing with the aging population, shifting care from hospitals to clinics. Although predicting medium-term prognosis after discharge can enhance care and reduce readmissions, yet no established model has been evaluated for both discrimination and calibration. This multicenter study developed and validated machine learning (ML) models—including logistic regression, random forests, extreme gradient boosting, and light gradient boosting— to predict 180-day mortality or emergency hospitalization in 4,904 HF patients with HF. Patients were randomly split into training and validation sets (8:2), and models were trained and evaluated accordingly. All models showed acceptable performance based on the area under the precision-recall curve, good calibration according to the calibration slope and Brier score, and effective risk stratification. The SHapley Additive exPlanations algorithm identified nursing care needs as a key predictor alongside established laboratory values for HF prognosis. ML models effectively predict the 180-day prognosis patients with HF, with nursing care needs highlighting the importance of multidisciplinary collaboration. Clinical Trial Registration: URL: https://www.umin.ac.jp/ctr; unique identifier: UMIN000054854
Global dynamics for a class of nonautonomous mosquito models with time delay and switching control strategy
Authors: Yu Qingwen , Wang Dongshu , Cheng Yaqiong
Published: February 2025

Mosquitoes serve as the primary vectors for several life-threatening pathogens, including malaria, dengue fever, and Zika virus. To effectively control the transmission of these diseases, a variety of integrated vector management strategies are currently employed to reduce mosquito population densities. This paper focuses on the sterile insect technique (SIT) and incompatible insect technique (IIT), which involves the release of sterile male mosquitoes to suppress wild mosquito populations, and delves into the impact of different release strategies on mosquito population dynamics. We established a switched mosquito population suppression model with time delay. We first investigate the existence and stability of the switching ordinary differential equation model, and derive some criteria for determining whether T-periodic solutions are stable or unstable. By taking the initial function as a solution to the delay-free model, we obtain sufficient conditions for existence of a unique or exactly two periodic solutions. Furthermore, we gain necessary and sufficient conditions for nonexis-tence of periodic solutions. Finally, the numerical results have been shown to further highlighted the effectiveness of our proposed model.
JUUUCAST – Erste Hilfe bei Problemen im Netz
Authors: Wütscher Swenja
Published: February 2025

JUUUPORT e. V. (2024). JUUUCAST. Erste Hilfe bei Problemen im Netz. Podcast, kostenlos, verfügbar auf diversen Podcast-Plattformen.
„Wenn der Klassenchat in der ganzen Schule umhergeht“ – der Podcast JUUUCAST bietet wertvolle, praxisorientierte Informationen, die speziell auf die Bedürfnisse und Erfahrungen Jugendlicher zugeschnitten sind. Das Peer-to-Peer-Angebot der Aufklärungs- und Beratungsplattform JUUUPORT richtet sich direkt von Jugendlichen an Jugendliche und hat zum Ziel, sie auf ihrem Weg durch die digitale Welt zu begleiten und zu stärken.
JUUUCAST sticht durch seine authentische, auf Augenhöhe geführte Moderation hervor: Die Moderator*innen, die selbst als JUUUPORT-Scouts aktiv sind, sprechen direkt an, was die Zielgruppe bewegt. Durch diese nahbare Peer-to-Peer-Herangehensweise werden Themen wie Datenschutz, Sexting und Gaming auf eine verständliche und für Jugendliche relevante Weise behandelt. Jede Episode dauert etwa 15 Minuten und gibt den Zuhörer*innen konkrete Handlungsempfehlungen, die ihnen helfen können, sich sicherer und verantwortungsbewusster im digitalen Raum zu bewegen.
Bisher sind zwei Folgen veröffentlicht: Die erste Episode – ‚Was ist JUUUPORT?‘ – bietet einen Überblick über die Mission der Plattform JUUUPORT und zeigt, wie das Beratungsangebot Jugendlichen bei digitalen Problemen wie Cybermobbing und Online-Gewalt hilft. In der zweiten Folge – ‚Cybermobbing – nicht mit uns!‘ – geht es um die Auswirkungen von Cybermobbing, konkrete Fallbeispiele werden diskutiert und Zuhörer*innen erhalten handlungsorientierte Tipps, wie sie sich vor solchen Erfahrungen schützen oder Hilfe suchen können. In Zukunft sollen auch externe Gäst*innen eingeladen werden, die den Blick auf bestimmte Entwicklungen im Netz erweitern und ergänzen.
Der Podcast fügt sich nahtlos in das umfassende Angebot von JUUUPORT ein, das sich auf die digitale Beratung und Unterstützung Jugendlicher spezialisiert hat. In Kombination mit den anderen Angeboten der Plattform – wie etwa der persönlichen Beratung und verschiedenen Präventionsmaßnahmen – ist JUUUCAST ein wertvoller Baustein in der digitalen Aufklärung und Medienbildung.
The Effect of Laughter Yoga Program to Reduce Stress and Increase Psychological Happiness among College Students
Authors: Fatima Hashem Darwesh  , Moaid Ismail Jarjis
Published: February 2025

Current research aims to achieve research Objective and hypothesis through identify the significancy and non-significant difference between pre-test, post-test and follow-up post-test for both scales (stress, psychological happiness) before applying the laughter yoga program on (15) participants of the experimental group, and after the program applied. Laughter yoga program has been prepared by the researchers depended on literature. For the stress scale (Cohen et al; 2004-13 items), and for the psychological happiness scale (Hills & Argyle ,2002- 28 items) has been used. For sure the validity and reliability of scales were verified. Then, the two scales as pre-test were applied on the participants of the experimental group, and the program was applied, then post-test was achieved, then the data processing by using (Spss). the results showed: The laughter yoga program is effectiveness to decreases stress and increased the psychological happiness. The study has presented some recommendations and suggestions.
The Aesthetics of Color in the Artworks of Artists Vasily Kandinsky and Pite Mondrian
Authors: Halkawt Aswad Asaad
Published: February 2025

The Aesthetics of Color in the Artworks of Artists Vasily Kandinsky and Pite Mondrian
Pendekatan Teaching at the Right Level dalam Mengatasi Kesenjangan Pemahaman Matematika Peserta Didik
Authors: Husna Fani Rahmawati , Firdaus Hana Puspita Eka , Indriati Erlyn
Published: February 2025

Mathematics is a fundamental compulsory subject in various fields of life and technology. However, many students consider mathematics difficult and boring, so many students have difficulty learning. This study aims to overcome the gap in mathematical understanding of class VII C students of SMP Negeri 1 Balung through the Teaching at the Right Level (TaRL) approach and the Problem Based Learning (PBL) learning model. The method used is Classroom Action Research (PTK) with two cycles. Each cycle involves the planning, implementation, observation, and reflection stages. This study was conducted on 31 students with statistical data presentation material. The results showed an increase in the average value from 79.4 in cycle I to 82.7 in cycle II. The increase in the lowest value from 54 to 67 indicated a reduction in the gap in understanding. In addition, the number of students who achieved completeness increased by 12.5%. The TaRL approach combined with PBL is effective in improving learning outcomes and reducing the gap in student abilities. However, this approach requires more preparation by teachers, including grouping students and creating learning materials that are appropriate to the level of student ability. TaRL can also be used to increase student interest, motivation, and learning activity.
Scientific basis of early intervention for infants and young children and their families
Authors:   St. Petersburg State University, Muhamedrahimov Rifkat
Published: February 2025

The adoption of the Concept of Early Intervention in the Russian Federation, the inclusion of early intervention for young children and their families into Federal law and its dissemination in regions of Russian Federation assumes familiarization of professionals with its interdisciplinary scientific basis. This work is aimed at literature reviewing and presenting in one article the basic concepts and early pioneer works that served as the basis for the early intervention as a field of interdisciplinary clinical, research and training activities. The results of the work indicate that in the period preceding the emergence of early intervention, and during its formation in the 1980s and 1990s, the international community provided studies in a wide range of infancy and early childhood research areas. New data were obtained and generalized in the field of child psychoanalysis and psychiatry, pediatrics, developmental psychology, neurobiology, the consequences of early deprivation, the effectiveness and cost-effectiveness of early childhood programs. The received scientific information was largely revolutionary, changing ideas about the abilities and early development of infants, as well as about intervention programs and methods. The studies of evidence-based early childhood intervention programs have shown their effectiveness and cost-effectiveness. To be effective, the early intervention requires to apply the scientific data in many areas: in intervention programs and methods, normative and methodical documents, research and training programs.