bluuebunny/crossref_metadata_2025 huggingface dataset:
MAPPROXIMATING STRESSES IN THE VICINITY OF A CAVITY EXPANDING AT A CONSTANT VELOCITY IN A MEDIUM WITH THE MOHR - COULOMB PLASTICITY CONDITION
Authors: Kotov V. L.
Published: July 2019

A one-dimensional problem of a spherical cavity expanding at a constant velocity from a point in an infinite elastoplastic medium is considered. The problem has a first-kind self-similar solution. Elastoplastic deformation of the soil is described based on Hooke's law and the Mohr-Coulomb yield criterion. An analytical solution of the problem in the elastic region contacting with the plastic yield region has been obtained. To determine stress and velocity fields in the plastic region, a known algorithm, based on the shooting method, of analyzing a boundary-value problem for a system of two first-order ordinary differential equations, including the fourth-order Runge - Kutta method, has been realized. An effective algorithm of numerically analyzing an expanding cavity problem, earlier proposed in the works by М. Forrestal et al., makes it possible to solve the problem accurately enough for practical applications.
A formula for determining the critical pressure - the minimal pressure required for the nucleation, accounting for internal pressure of a cavity in the framework of the Mohr - Coulomb yield criterion, has been derived, which is a generalization of the earlier published solution for an elastic ideally plastic medium with Tresca's criterion. The obtained critical value was compared with a numerical solution in a full formulation at the cavity expansion velocities close to zero in a wide range of variation of the parameters of the Mohr - Coulomb yield criterion. It is shown that the inaccuracy of the approximation of the proposed formula does not exceed 6% for the variation of the internal friction coefficient all over the admissible range, and for the initial value of the yield strength increasing by three orders of magnitude.
ABOUT THE CALCULATION OF INTERNAL STRESSES FROM MESODEFECTS ACCUMULATING AT THE BOUNDARIES DURING PLASTIC DEFORMATION OF SOLIDS
Authors: Kirikov S. V. , Perevezentsev V. N.
Published: July 2019

A new method of calculation of elastic stress fields from internal interfaces (intergranular and interphase boundaries) of plastically deformed polycrystals is proposed. As elementary sources of stress fields, rectangular boundary segments containing uniformly distributed segments of dislocation families accumulating on these segments during plastic deformation are considered. It is shown that the elastic stresses field from a segment with arbitrary geometry of plastic flow and segment orientation can be represented as a superposition of fields from four families of continually distributed dislocation segments with tangential and normal components of the Burgers vector. Analytical expressions for the elastic stress tensor components from each of the four families are obtained. In the limiting case, when the length of dislocation segments tends to infinity, the resulting expressions for the components of the elastic stress field transform known expressions for rotational and shear mesodefects. If dislocation segments have a normal burgers vector, then the stress field is equivalent to the stress field from the biaxial dipole of wedge disclinations. In the case of tangential components of the burgers vector, the field is equivalent to the stress field of the planar mesodefect. As an example of the method application, the calculation of internal stress fields in the plastically deformed crystal containing uniformly distributed cubic particles of the second phase is given. It is shown that the intensity of internal stresses at a given value of strain increases with increasing volume fraction of particles. It is found that for a given volume fraction of the second phase, the internal stresses does not depend on their size.
A MODEL OF PILE DRIVING BY MULTIPLE IMPACTS OF FALLING HAMMER
Authors: Dubinsky A. V.
Published: July 2019

Calculations related to pile driving play an important role in construction. Therefore, corresponding processes are controlled by regulatory documents, including the necessary formulas, which are accompanied by numerous tables and graphs, allowing the use of techniques in specific conditions of construction. The basis of such applied methods are the results of research in mechanics; the results of such studies are widely presented in the literature. This article is made within the framework of such studies.
The article presents an approximate approach based on the evaluation of the real values of the parameters that determine the process of driving the pile. The proposed approach allowed to obtain an approximate formula to calculate the motion of the pile in soil by successive blows of the hammer falling freely. The following ways to analyze and improve models within this approach are outlined: (1) analysis of the accuracy of the proposed model by its presentation with the results of experiments and calculations using other models as well as with recommendations of normative instruments; (2) generalization of the model for the case when the mechanical properties of the soil vary depending on the depth of immersion into the soil.
Relevansi Ijma’ Dan Qiyas Dalam Struktur Hukum Islam Dan Struktur Hukum Positif Di Indonesia
Authors: Balya Deden Ibnu
Published: July 2019

Abstract
The concept of ijma ', and its relevance in construction and improvisation of Islamic law is part of the Islamic law studies, which can always develop according to place and time, time in terms of times and regions in the sense of the state. Ijma', of course functions as a tool for taking legal conclusions, both those whose sources are divine and the sunnah of the Prophet Muhammad PBUH. This paper is qualitative writing, with library research methods, with primery data is sources of books and legal nomenclature, and using the descriptive analysis. Based on the analysis, it is known that the level of relevance of ijma as a method, till nowaday, its relevance is still very high, especially with the region and the spread of Islam that is indeed cross-country, cross-nation, and across cultures. Ijma 'of the ulama becomes very important, because in addition to being a response to the development of the times, ijma' also remains a necessity for Muslims, considering that not everyone is able to do istinbaht / legal conclusions in Islam.
Keywords : Ijma’  and Qiyas, Source of Islamic Law, Legal Development.
ACCIDENT INSURANCE FOR INFORMAL SECTOR WORKERS IN INDONESIA
Authors: On Madya Sri Denti , Nurwahyuni Atik
Published: July 2019

Workplace accidents are unwanted and unexpected events that can cause loss of life and property. The Social Security Law in Indonesia mandates that Work Accident Guarantees be mandatory for every workforce in Indonesia. To see how work accident insurance for informal sector workers in Indonesia. This research was carried out by library study method. The subjects of this study are data in the form of articles and several source books related to the theme of the research, namely concerning workplace accidents and social security of informal sector workers in Indonesia. The number of work accidents, especially in the informal sector in Indonesia, still tends to be high, especially in construction work. Policies in the field of occupational health and safety (K3) still focus on formal sector workers rather than informal worker. Keyword: work accident, social security, informal sector
PENGGUNAAN MULTIPLEKS POLYMERASE CHAIN REACTION (PCR) DALAM MENDETEKSI JAMUR DERMATOFIT
Authors: Anwar Aan Yulianingsih , Sjahril Rizalinda - , Hamid Firdaus -
Published: July 2019

Dermatofitosis adalah salah satu jamur yang terdiri dari tiga genus: Epidermophyton, Trichophyton dan Microsporum. Tujuan penelitian ini untuk mengidentifikasi jenis jamur dermatofit dengan metode Multipleks PCR yang ditemukan pada penderita dermatofitosis di Kota Makassar. Penelitian observasi laboratorium dengan menguji 50 sampel yang diperoleh dari beberapa klinik dan sekolah dasar di Makassar. Hasil penelitian menunjukan bahwa Microsporum spp. terbanyak teridentifikasi (54%). Kami menyarankan teknik Multipleks PCR ini digunakan untuk konfirmasi jenis dermatofit sehingga pengobatan dapat lebih cepat dan tepat.
PANCs - PLANTAS ALIMENTÍCIAS NÃO CONVENCIONAIS E SEUS BENEFÍCIOS NUTRICIONAIS
Authors: Liberato Pricila da Silva , Lima Danielly Vasconcelos Travassos de , Silva Geuba Maria Bernardo da
Published: July 2019

O conceito de alimentação muda conforme o conhecimento da população sobre alimentos saudáveis e seus benefícios. A busca por uma vida saudável leva as pessoas a buscarem novas formas de alimentação tendo em vista sua funcionalidade e sustentabilidade. O presente trabalho teve como objetivo fazer uma revisão bibliográfica acerca do tema PANC, identificar as propriedades funcionais, nutrientes, valor nutricional, formas de consumo e inserção na alimentação humana. Realizou-se uma busca sistemática da bibliografia publicada nas bases de dados na “Literatura Latino-Americana e do Caribe em Ciências da Saúde” (LILACS), “Medical Literature Analysis and Retrieval System On-line” (MEDLINE) e “Google Acadêmico”. Os descritores utilizados para a busca foram: Plantas; Nutricional; Funcional; Antioxidantes; Anti-inflamatório; Consumo; Benefícios. Foram selecionados um total de 20 artigos publicados entre os anos de 2009 a 2019, nos idiomas português, inglês e espanhol. Nesse trabalho identificou-se que de um modo geral as PANCs em sua maioria apresentam fator nutricional elevado, aumentando para o indivíduo que as consomem a ingestão diária vitaminas e minerais essenciais ao desenvolvimento humano, como visto em alguns casos são capazes de substituir as hortaliças convencionais, podendo ser inserida na alimentação diária, cultivadas em pequenos espaços e jardins, podendo também ser comercializada gerando uma fonte de renda. Conclui-se que se faz necessário que os pesquisadores aprofundem seus estudos em relação ao tema, pois existe uma grande diversidade a ser explorado. Por fim, verificou-se a necessidade da população adquiri mais conhecimento para que essas PANCs sejam inseridas na sua alimentação diária.
CARACTERIZAÇÃO DAS LESÕES DE Gallus gallus PROVOCADAS EM RINHAS NO ESTADO DA PARAÍBA, BRASIL
Authors: Melo Cynthia Germoglio Farias de , Costa Marcos Antônio Jerônimo , Sobral Felipe Eduardo da Silva
Published: July 2019

No Estado da Paraíba tem-se observado com frequência um grande número de animais utilizados para práticas julgadas esportistas como rinhas. Apesar do grande número de lesões observadas nos animais vítimas destes maus tratos, poucos trabalhos são observados relatando estas ocorrências mais detalhadamente. Com objetivo de avaliar os traumas sofridos pelas aves da espécie Gallus gallus, vítima de maus tratos em rinhas, foram analisados 23 espécimes aprendidas pela polícia florestal no município de Santa Rita - PB, e atendidos pelo CETAS (Centro de Triagem de Animais Silvestres). Dos vinte e três indivíduos de G. gallus apreendidos, 100% apresentaram ausência de penas no alto da cabeça (testa, vértice e nuca) e coxa, 78,2% exibiam lesões oculares com pelo menos um dos olhos cegos, 39% necrose auricular, 82,6% necrose da crista, 39% perfurações nas regiões peitoral e escapular, 34,7% perfurações na testa e 17,3% apresentavam fratura de mandíbula. A principal causa das lesões observadas ocorre devido o uso de instrumentos de metal como biqueiras e esporas colocados no animal para provocar maior dano no adversário. Foi verificado ainda que algumas das lesões observadas provocam nos animais dificuldades de alimentação, comportamento de corte e vocalização.
Evaluating the role of dithiolane rich fraction of Ferula asafoetida (apiaceae) for its antiproliferative and apoptotic properties: in vitro studies
Authors: Verma S. , Khambhala P. , Joshi S. , Kothari V. , Patel T. , Seshadri S.
Published: July 2019

Summary. Asafoetida resin has been reported for various biological activities but its use has been widely restricted owing to its pungent smell and pool water solubility. Aim: In vitro study of the anticancer potential of microwave-extracted essential oil (EO) of Ferula asafoetida. Materials and Methods: The phytochemical investigation and in vitro cytotoxicity assessment was carried out in two human liver cancer cell lines. The expression of NFKB1, TGFB1, TNF, CASP3 was analyzed by reverse transcription polymerase chain reaction. Results: Ferula asafoetida EO contains high concentrations of dithiolane, which possess antiproliferative activity in human liver carcinoma cell lines (HepG2 and SK-Hep1) in a dose-dependent manner. The bioactive compounds in F. asafoetida are capable of induction of apoptosis and altered NF-kB and TGF-β signalling with increase in caspase-3 and TNF-α expression. Conclusion: Further elucidation of bioactive molecules and underlying mechanisms could lead to potential intervention in liver cancer in animal models. The safety and efficacy as well as the mode of EO action in animal models would be highly crucial.
Antitumor effects and hematotoxicity of C60-Cis-Pt nanocomplex in mice with Lewis lung carcinoma
Authors: Prylutska S.V. , Lynchak O.V. , Kostjukov V.V. , Evstigneev M.P. , Remeniak O.V. , Rybalchenko V.K. , Prylutskyy Yu.I. , Ritter U. , Scharff P.
Published: July 2019

Summary. Background: Cisplatin (Cis-Pt) is a widely used anticancer drug but its therapeutic efficiency is limited by hemato-, cardio-, hepato-, nephro- and neurotoxicity. Complexation of Cis-Pt with C60 fullerene nanoparticle will allow to enhance the antitumor activity of the drug and to reduce its side toxic effects. Aim: To estimate the antitumor effects of С60-Cis-Pt nanocomplex in Lewis lung carcinoma (LLC) and analyze hematological toxicity in tumor-bearing mice. Materials and Methods: Complexation of C60 fullerene and Cis-Pt molecule was studied by computer simulation. С60-Cis-Pt nanocomplex was i.p. injected to LLC-bearing mice in a total dose of 7.5 mg/kg (C60:Cis-Pt as 3.75:3.75 mg/kg). The survival of tumor-bearing mice and the relative reduction of tumor weight was recorded. Blood indices were determined using the Particle Counter PCE­210 automatic hematology analyzer. Results: Computer simulation demonstrated the formation of С60-Cis-Pt nanocomplex in physiological medium and its stability due to the hydrophobic interactions. Treatment with C60-Cis-Pt nanocomplex increased survival time of LLC-bearing mice by 32%, normalized hemoglobin content (up to 100 g/l), erythrocyte and platelet count as compared to the untreated LLC-bearing mice. Tumor weight decreased by 35.5%; the mitotic index of tumor cells decreased by 78%, and apoptotic index increased by 75%. The revealed effects of the C60-Cis-Pt nanocomplex were more pronounced than the effects of Cis-Pt or C60 fullerene alone in equivalent dose. Conclusion: Treatment with C60-Cis-Pt nanocomplex prolonged the survival of LLC-bearing mice and reduced anemia in LLC-bearing mice.
Proinflammatory effects of photoactivated methylene blue on rat model of Walker 256 carcinosarcoma
Authors: Petrellis M.C. , Frigo L. , Ribeiro W. , Leal-Junior E.C.P. , Oliveira F.R. , Maria D.A. , Lopes-Martins R.Á.B.
Published: July 2019

Summary. Background. Photodynamic therapy (PDT) is an anticancer therapy that associates the photosensitizer (PS), oxygen and light to destroy cancer cells. Methylene blue (MB) is considered a second generation phenothiazine dye with excellent photochemical properties. Aim: To evaluate whether MB-mediated PDT can induce oxidative stress and inflammation, therefore, interfering tumor growth. Materials and Methods: The study was conducted on Wistar rats transplanted with Walker 256 carcinosarcoma (W256). The proinflammatory interleukins levels (IL-1β, IL-6, IL-10, TNF-α) were determined by ELISA, mRNA expression of COX-1, COX-2, iNOS and eNOS by RT-PCR, lipid peroxidation was measured by the TBARS method. Moreover, myeloperoxidase (MPO) activity in neutrophils was determined by MPO activity assay. All indices mentioned above were determined in tumor tissue. Kaplan — Meier and Gehan — Breslow — Wilcoxon tests were used for survival analysis. Results: We found that the treatment of W256 with 0.1% MB + 1 J/cm2 provoked a significant increase in the interleukins levels (IL-1β, IL-6, IL-10, TNF-α), prostaglandin E2, the mRNA expression of COX-2, iNOS, lipid peroxidation and MPO activity in tumor tissue, which were statistically different (p < 0.05) compared to other experimental and control groups. The results of the estimation of survival curves show a greater probability of survival in 0.1% MB + 1 J/cm2 (total energy dose =142.8 J/cm2) treated group. Conclusion: Our results suggest that treatment of W256 with 0.1% MB + 1 J/cm2 was able to promote cytotoxic effects in tumor tissue by the generation of reactive oxygen species causing inflammation and thus interfering in the tumor growth.
Investigation of dosimetric impact of organ motion in static and dynamic conditions for three stereotactic ablative body radiotherapy techniques: 3D conformal radiotherapy, intensity modulated radiation therapy, and volumetric modulated arc therapy by usi
Authors: Tajaldeen A. , Alghamdi S.
Published: July 2019

Summary. Aim: To investigate the use of PRESAGE 3D dosimeters to quantify the dosimetric variation between the static and dynamic conditions of three stereotactic ablative body radiotherapy techniques. Materials and Methods: An in-house custom-designed thorax dynamic phantom was designed to simulate the tumor motion in two directions (i.e., superior/inferior (Z-axis) and anterior/posterior (Y-axis)). The PRESAGE dosimeter was attached to the moving arm of the phantom and irradiated in two scenarios (static and dynamic) using three stereotactic ablative body radiotherapy (SABR) techniques: 3D conformal radiotherapy (3D CRT), intensity-modulated radiation therapy (IMRT), and volumetric modulated arc therapy (VMAT). Results: The highest differences in the mean volume measurements between the two conditions were noticed in IMRT (0.14 cm3) and 3D CRT (0.13 cm3). The mean volume measurements of the VMAT showed the lowest difference between the static and dynamic conditions of 0.10 cm3. The gamma analysis for 3%, 3-mm criterion showed passing rates of < 1 for 3D CRT, IMRT, and VMAT. Conclusion: This study quantify the dosimetric variations which are caused by the tumor motion in lung cases. In the SABR of the lung for QA purposes, this could help in identifying the prescription dose coverage due to tumor movement and correlate with the planned dose using 3D dosimeters like PRESAGE.
PENGARUH PEMAHAMAN KEAGAMAAN MASYARAKAT DESA DEMPET TERHADAP POLA RELASI SUAMI ISTRI BEKERJA
Authors: Ida Ifti
Published: July 2019

Relasi suami istri terbentuk setelah terjadinya akad perkawinan yang kemudian menimbulkan hak dan kewajiban antara keduanya. Suami istri masing-masing memiliki beban tanggung jawab dalam menjalankan kehidupan rumah tangga. Realitas yang terjadi di masyarakat Desa Dempet justru banyak dari mereka yang mengetahui hak dan kewajiban namun tidak menghiraukan beban tanggung jawab sebagai suami istri. Kondisi ini akhirnya menimbulkan konflik bagi istri yang ikut bekerja di luar rumah, tetapi  tidak terjadi pertukaran peran antara suami istri dalam urusan domestik maupun mencari nafkah. Akibatnya istri mengalami perkembangan beban sebagai ibu rumah tangga dan sebagai istri pekerja. Hal ini dipengaruhi oleh figur kyai yang memahami agama menggunakan lensa budaya patriarki, sementara kyai di masyarakat memiliki posisi yang sangat signifikan yakni sebagai figur untuk ditiru dan diteladani dalam kehidupan sehari-sehari. Pemahaman agama ini mengakibatkan beberapa dampak terhadap pola relasi suami istri bekerja, yakni terjadinya pemahaman keagamaan masyarakat yang bersifat konservatif dan bersifat moderat. Tulisan ini mendeskripsikan tentang masalah pengaruh pemahaman keagamaan dan dampak pemahaman keagamaan terhadap pola relasi suami istri bekerja dari segi sosiologis.
PENGARUH UKURAN PERUSAHAAN, JENIS OPINI AUDITOR, UKURAN KAP DAN AUDIT TENURE TERHADAP AUDIT DELAY
Authors: Annisa Dea
Published: July 2019

Penelitian ini bertujuan untuk menilai pengaruh ukuran perusahaan, jenis opini auditor, ukuran perusahaan audit dan audit tenure pada audit delay yang terdaftar di Bursa Efek Indonesia periode 2010 - 2014. Penelitian ini menggunakan sampel 90 perusahaan manufaktur, analisis Teknik yang digunakan adalah regresi berganda dengan SPSS 20. terhadap audit delay, (3) jenis Opini auditor berpengaruh negatif terhadap audit delay, (4) ukuran perusahaan tidak berpengaruh negatif terhadap audit delay, (5) audit tenure berpengaruh negatif terhadap audit delay. Temuan penelitian menunjukkan bahwa jenis opini auditor berpengaruh negatif terhadap audit delay dengan signifikansi 0,002
PENGARUH DANA PIHAK KETIGA, NON PERFORMING FINANCING, TINGKAT BAGI HASIL DAN MODAL SENDIRI TERHADAP PROFITABILITAS DENGAN PEMBIAYAAN BAGI HASIL SEBAGAI VARIABEL INTERVENING PADA PERBANKAN SYARIAH
Authors: Angraini Dila
Published: July 2019

Tujuan penelitian ini untuk menguji pengaruh Third Party Funds, Non Performing Financing, Tingkat Bagi Hasil dan Modal Sendiri terhadap Profitabilitas Pembajakan Terhadap Hasil sebagai variabel intervening. Penelitian ini menggunakan data sekunder dari periode 2011-2015 ke perbankan syariah. Teknik pengambilan sampel menggunakan purposive sampling. Alat untuk mengolah data menggunakan SPSS 22.0. Hasil penelitian menunjukkan bahwa Third Party Funds memiliki pengaruh signifikan positif terhadap profitabilitas sedangkan Third Party Funds tidak memiliki pengaruh negatif terhadap Pembiayaan Bagi Hasil dan Pembiayaan Bagi Hasil memiliki pengaruh signifikan negatif terhadap Profitabilitas Selanjutnya Third Party Funds merupakan pengaruh yang signifikan terhadap profitabilitas tetapi belanja bagi hasil bukan merupakan variabel intervening antara Third Party Funds dan profitabilitas. Non Performing Financing memiliki pengaruh yang signifikan terhadap Profitabilitas dan Non Performing Financing tidak memiliki pengaruh yang signifikan terhadap belanja bagi hasil pada hasil bagi berikutnya memiliki pengaruh yang signifikan secara negatif terhadap profitabilitas. Selanjutnya Pembiayaan Bagi Hasil merupakan variabel intervening antara Non Performing Financing dan Profitabilitas. Tingkat Bagi Hasil tidak memiliki pengaruh yang signifikan terhadap profitabilitas dan tingkat bagi hasil tidak memiliki pengaruh yang signifikan secara negatif terhadap suku cadang dan hasil bagi hasil memiliki pengaruh negatif yang signifikan terhadap profitabilitas. Selanjutnya bagi bagi hasil merupakan variabel intervening antara tingkat bagi hasil dan profitabilitas. Modal Sendiri tidak memiliki pengaruh yang signifikan terhadap profitabilitas danmodal sendiri memiliki pengaruh positif terhadap belanja bagi hasil, tetapipembiayaan bagi hasil memiliki pengaruh yang signifikan secara negatif terhadap profitabilitas. Jadi hasil bagi bagi bukan merupakan variabel intervening antara modal sendiri dan profitabilitas.
ANALYSIS OF PUBLIC PERCEPTION AND INTEREST IN THE DECISION TO CHOOSE ACCOUNTING MAJOR
Authors: Prihanto Hendi , Watriningsih Watriningsih
Published: July 2019

This study aims to find out the influence of public perception and interest on the decision to choose accounting major. The population of the study is high schools in Kebayoran Baru. The data is collected using clusters in South Jakarta. The data is obtained by distributing questionnaires to the students in twelfth grade who will continue their study to higher education. This study applies quantitative method with causal relationship to determine the influence of the independent variables (perception and interest) on the dependent variable (public decision to choose accounting department). Research findings show that the perception and interest partially influence the decision to choose in positive and significant manner.
PENGARUH INTELEKTUAL CAPITAL TERHADAP PROFITABILITAS PADA PERUSAHAAN INDUSTRI JASA SEKTOR PROPERTI DAN REAL ESTATE DI BURSA EFEK INDONESIA TAHUN 2011 â€“2015
Authors: Purnomo Listiya Ike
Published: July 2019

Penelitian ini bertujuan untuk mengetahui apakah Intellectual Capital diproksikan dengan Value Added Intellectual Coeffisien berpengaruh signifikan terhadap profitabilitas yang diukur dengan ROA menggunakan metode analisis Data Panel yang diolah dengan program Eviews 7.0. Value Added Capital Employed (VACA) menunjukkan t-statistik> t-tabel 0,610972 <1,97253, dan nilai probabilitasnya 0,5420> 0,05 membuktikan tidak ada pengaruh signifikan dari Value Added Capital Employed (VACA) pada Return On Assets (ROA). Nilai Tambah Modal Manusia (VAHU) menunjukkan t-statistik> t-tabel yaitu 5,324171> 1,97253, dan nilai probabilitas 0,0000 <0,05 membuktikan terdapat pengaruh signifikan Value Added Human Capital (VAHU) terhadap Return On Assets (ROA). Structural Capital Value Added (STVA) menunjukkan t-statistik> t-tabel adalah 2,559279> 1,97253, dan nilai probabilitas 0,0113 <0,05membuktikan bahwa ada pengaruh signifikan dari Structural Capital Value Added (STVA) terhadap Return On Assets (ROA) . Nilai Tambah Intelektual Koefisien (VAIC) menunjukkan t-statistik> t-tabel yaitu 20,21010> 1,97253, dan nilai probabilitas 0,0000 <0,05 membuktikan ada pengaruh signifikan Value Added Intellectual Coefficient (VAIC) terhadap Return On Assets (ROA) . Hasil uji simultan menunjukkan F-statistic> F-tabel adalah 59,13104> 2,42 dan nilai probabilitas 0,000000 <0,05 membuktikkan bersama-sama elemen Intellectual Capital memiliki pengaruh yang signifikan terhadap Return On Assets (ROA). Adjusted R-Squared (R2) sebesar 0,558249 menunjukkan bahwa persentase kontribusi variabel independen terhadap variabel dependen adalah 55,8%. Berdasarkan hasil pengujian dan pembahasan, dapat disimpulkan bahwa Intellectual Capital (IC) yang diukur dengan Value Added Capital Employed (VACA), Value Added Human Capital (VAHU), Structural Capital Value Added (STVA) dan Value Added Intellectual Capital (VAIC) Memiliki pengaruh yang signifikan terhadap profitabilitas yang diukur dengan Return On Assets (ROA).
THE INFLUENCE OF COMPENSATION SUITABILITY AND INTERNAL CONTROL SYSTEM TO FRAUDWITH MORALITY AS MODERATING VARIABLE
Authors: Junaidi Junaidi , Ubaidillah Maulidani
Published: July 2019

This study aims to observe the effect of compensation suitability and internal control system on fraud. Testing is done directly and indirectly. Indirect influence is made through moderating variable of morality as a moderator of the influence of compensation suitability and internal control system on fraud. Data obtained by purposive sampling. As many as 79 processed data were obtained through the distribution of questionnaires to stakeholders in local government organizations in Pemekasan District of East Java. The parametric test fails because the residual data is not normally distributed even though the outliersâ€™data has been removedfrom the observation. The test was performed using partial least square due to the small sample. Testing the hypothesis proves that the three variables have a significant negative effect on fraud. This confirms the importance of internal control system and compensation suitability as a means of anticipating fraud. Conversely, moderating variable of expected morality may reinforce the nonlinear influence of compensatory suitability and internal control systems not significantly explain fraud.
GOING CONCERN AUDIT DETERMINATION IN INDONESIAN AGRICULTURAL SECTOR
Authors: Hakim Mohamad Zulman
Published: July 2019

The purpose of this research is to know the influence of debt to equity ratio(DER), company size (SIZE), current ratio (CR) and reputation of PublicAccounting Firm (KAP) to going concern audit opinion (GCAO) in agriculturalsector companies listed in Indonesia Stock Exchange period 2012-2016. The study population includes all agricultural sector companies listed in Indonesia Stock Exchange period 2012-2016. The sampling technique used purposive sampling technique with sample of 16 companies and 80 observations. Data analysis method used is panel data logistic regression analysis with using program EViews (Econometric Views) version 9.0. The results showed that the debt to equity ratio (DER) has a positive effect to going concern audit opinion (GCAO), the size of the company (SIZE) has a negative effect to going concern audit opinion (GCAO), current ratio (CR) and reputation of Public Accounting Firm (KAP) doesnâ€™ t affect the going concern audit opinion (GCAO).
Role of Tumor Necrosis Factor alpha promoter polymorphisms in interferon related side effects in chronic hepatitis B patients under interferon alpha 2b treatment
Authors: İnkaya Ahmet Çağkan , Türk Arıbaş Emel , Kandemir Bahar , Acar Hasan , Bitirgen Mehmet
Published: July 2019

Objective(s). Interferon alpha therapy is associated with series of adverse effects leading premature discontinuation of treatment. Here we aimed to determine the effects of Tumor necrosis alpha promoter polymorphisms on interferon related side effects during interferon alpha 2b treatment in chronic hepatitis B patients

Material and Method(s). This observational study enrolled 50 chronic hepatitis B patients, who were treated with interferon alpha 2b 10 tiw plus lamivudine 100mg/day at Selçuk University Meram Medical Faculty Department of Infectious Diseases and Clinical Bacteriology between 2006-2007. Patients were followed-up with complete blood count, transaminases and amylase monthly at out patient clinics of our department. All patients were asked to fill a questionnaire to evaluate the interferon related side effects at every visit. Tumor necrosis factor alpha -238 and -308 polymorphisms were investigated with PCR-Restriction fragment length polymorphisms.

Result(s) and Conclusion  Arthralgia was present in 93.8% of patients. Exhaustion, loss of appetite, mount dryness and fever are the leading complaints of the patients. Median complaint scores were 9, 9.5, 11 and 5 at 4th, 12th, 24th and 48th week visits, respectively. Thrombocytopenia and leucopenia were detected in 8 (16%) and 5 (10%) patients, respectively. One-third of the patients reported depressive mood however, depression was diagnosed in 5 (10%) patients. TNF alpha promoter 238GG and 308GG allele was present in 42/50 and 43/50 patients, respectively. No association was found between TNF promoter allele and certain patient-reported side effect, complaint score, hematological and psychological adverse effects. TNF alpha promoter polymorphisms do not contribute to occurrence of IFN alpha treatment related side effects.
Assessment of molecular mechanisms and potential biomarkers in bladder urothelial carcinoma
Authors: Sucularlı Ceren
Published: July 2019

Objective: Bladder cancer ranks 10th among the most common cancers worldwide, effecting mostly man than women. The aim of this study is to perform a detailed gene expression analysis of bladder urothelial carcinoma to reveal altered molecular mechanisms and to find potential biomarkers for this cancer.

Materials and Methods: Bladder urothelial carcinoma RNA-seq data from TCGA and normal bladder samples from GTEx were analyzed by using GEPIA. Differentially expressed genes were annotated to GO-BP and KEGG pathway terms with DAVID and PPI networks were constructed by STRING. The association of upregulated cell cycle pathway proteins and patient survival was further investigated.

Results: Upregulated genes mainly annotated to cell cycle, p53 signaling and oocyte meiosis and maturation pathways and cell cycle related GO-BP terms. Downregulated genes mostly annotated to adhesion, ECM-receptor interaction, vascular smooth muscle contraction and cardiomyopathy related KEGG pathways and muscle related GO-BP terms. The protein products of six cell cycle genes, which were upregulated in bladder urothelial carcinoma, showed significant association with patient survival.

Conclusion: The results of this study showed altered molecular mechanisms and increased our understanding in bladder urothelial carcinoma, proposed potential prognostic biomarkers.
Comparison Between Feature-Based and Convolutional Neural Network–Based Computer-Aided Diagnosis for Breast Cancer Classification in Digital Breast Tomosynthesis
Authors: Chan Siwa , Yeh Jinn-Yi
Published: July 2019

Digital breast tomosynthesis (DBT) is a promising new technique for breast cancer diagnosis. DBT has the potential to overcome the tissue superimposition problems that occur on traditional mammograms for tumor detection. However, DBT generates numerous images, thereby creating a heavy workload for radiologists. Therefore, constructing an automatic computer-aided diagnosis (CAD) system for DBT image analysis is necessary. This study compared feature-based CAD and convolutional neural network (CNN)-based CAD for breast cancer classification from DBT images. The research methods included image preprocessing, candidate tumor identification, three-dimensional feature generation, classification, image cropping, augmentation, CNN model design, and deep learning. The precision rates (standard deviation) of the LeNet-based CNN CAD and the feature-based CAD for breast cancer classification were 89.84 (0.013) and 84.46 (0.082), respectively. The T value was -4.091 and the P value was 0.00 < 0.05, which indicate that the LeNet-based CNN CAD significantly outperform the feature-based CAD. However, there is no significantly differences between the LeNet-based CNN CAD and the feature-based CAD on other criteria. The results can be applied to clinical medicine and assist radiologists in breast cancer identification.
PARTISIPASI PUBLIK DAN KETERBUKAAN INFORMASI DALAM PENYUSUNAN KEBIJAKAN
Authors: Rahma Ida
Published: July 2019

Public participation can be understood as activities undertaken to affect public policy formation process. Public participation is important to ensure that any policy that produced not only benefit certain people, but also a positive impact on society. The process can be performed through the stages of agenda setting, policy formulation and implementation. This paper is about to describe the transformation of society prevailing in Aceh after the peace agreement. Review of the literature of choice in this paper, which is supported by a wide range of documents related to public participation, freedom of public information, and peace building. The results of this study indicate that public participation in policy formation in Aceh have ups and downs. Post-signatories to the peace agreement, the level of public participation is very good especially in the establishment of the Law on Governing Aceh and Aceh Qanun number. Next, in 2009-2014 public participation in policy formation decreased. Furthermore, the level of public participation in policy formation is determined by freedom of public information.
The effect of thermal gradient design on the evaluation of
thermoregulation in snakes
Authors:   Hibraim Perez-Mendoza
Published: July 2019

Hertz et al. (1993) designed what is now the most widely used protocol to analyse the thermal strategies and efficiency of small squamates. Preferred temperature range (Tp) is one of the most important variables required for determining the thermal efficiency index, and is calculated by monitoring the body temperature of the individuals in an enclosure containing a thermal gradient. Although thermoregulation studies of lizards have traditionally employed thermal gradients under laboratory conditions, this approach is not suitable for snakes given that such thermal gradients do not accurately represent their natural thermal environment and thus may result in snakes selecting suboptimal temperatures. Here, we compare
the results of this thermal efficiency protocol using a laboratory thermal gradient (LG) and a semi-captivity thermal gradient (SCG) in the rattlesnake Crotalus polystictus. We found traces of seasonal variation in the SCG Tp, but this could not be assessed in the LG. Tp from the LG was much higher (29 – 34.3 °C) than from the SCG (22.5-30.9 °C). Values for the accuracy of thermoregulation (db) and thermal quality of the environment (de) indices from the LG were consistently higher than from the SCG. However, the efficiency of thermoregulation (E) was higher when calculated from the SCG. Tp estimates were wider than most that have been obtained from other snake species, suggesting that C. polystictus is eurythermic. The Blowin Demers and Weatherhead index was nearly identical in both gradients. Results from the LG indicated that C. polystictus is an inaccurate and inefficient thermoregulator, due to the higher temperatures chosen in this environment. In contrast, results from the SCG suggested that it is a highly accurate and active thermoregulator. We suggest that the LG could represent a stressful environment for snakes, and, as a consequence, they might select higher temperatures to increase anti-predatory performance at the expense of less efficient thermoregulation. Generally, a thermal gradient that more accurately replicates the natural habitat of snake species should reduce stress and result in more robust estimates of thermoregulatory variables.
Las Redes Sociales de Internet para la promoción de pueblos turísticos
Authors: Martínez Carballo Massiel , Robert Beatón Martha Omara , Torres Hechavarría Lisandra
Published: July 2019

Las redes sociales de Internet se tornan un medio altamente efectivo para la comunicación de atractivos turísticos, partiendo de la idea de que una empresa o destino turístico está presente hoy en una red social, aunque la directiva de los mismos esté consciente de ello o no, le confiere especial importancia. El presente trabajo persiguió como objetivo proponer acciones para la gestión de las redes sociales de Internet en los pueblos turísticos cubanos. Se aplicaron métodos y técnicas como: la revisión bibliográfica, el inductivo-deductivo y análisis-síntesis, entrevistas, así como un benchmarking en función del comportamiento de las redes sociales de Internet en tres pueblos turísticos: Puebla, Obermutten y Morella, lo cual permitió un acercamiento al alcance y el empleo de las mismas, al mismo tiempo que contribuyó a la propuesta de acciones encaminadas a su gestión en pueblos turísticos cubanos.
Desarrollo turístico con enfoque sistémico, un reto hacia la sostenibilidad, valle de Vilcabamba
Authors: Vladimir Paladines Gustavo , Suárez Velasco Jenny Elizabeth , Salinas Chávez Eros
Published: July 2019

Ecuador está interesado en potenciar del desarrollo turístico, Vilcabamba posee un aumento de turistas notable lo que ha traído consigo oferta de productos y servicios turísticos sin un control técnico adecuado, para la solución de este problema se tuvo como objetivo, demostrar la validez de un desarrollo turístico con enfoque sistémico que permita sostenibilidad. La investigación se desarrolló partir de un enfoque cuali-cuantitativo  de tipo descriptiva, exploratoria de campo, se concluyó que el modelo de Sergio Molina  es un conjunto  de procedimientos relacionados  e integrados  entre sí, que al lograr  un enfoque sistémico en sus elementos se alcanza una perspectiva holística más centrada en  lograr un desarrollo turístico sostenible, donde  la  población receptora juega un papel  fundamental, además lograr la integración de los elementos del sistema turístico contribuirá al bienestar de la parroquia, un empoderamiento de la comunidad hará posible un desarrollo ordenado y racional.
Marketing digital como una estrategia para el turismo
Authors: Carrasco R. Tatiana
Published: July 2019

El marketing es el proceso por el que las empresas crean valor para los clientes y construyen fuertes relaciones con los mismos para así obtener el valor de ellos a cambio de satisfacer las necesidades de manera rentable. La Social Media Marketing sirve para promover conversaciones con el mercado y la sociedad, que respeten los principios de la Web Social, y así tener el poder de acceder al sitio web o red social de la empresa para conocer acerca de sus productos y servicios, conocer las opiniones de otros clientes, solicitar información específica, hacer pedidos, pagar online y comentar hacer de su experiencia.

Hoy en día las empresas basan su estrategia de posicionamiento y generación de demanda online. También gestionan sus campañas y estrategias para atraer al usuario y generar nuevas experiencias, las organizaciones deben determinar las necesidades, deseos e intereses de los mercados meta y proporcionar las satisfacciones deseadas de manera más efectiva y eficiente que la de los competidores, de tal manera que mantenga o mejore el bienestar del consumidor y de la sociedad

Cada vez se está más conectados en la tecnología con los dispositivos, en la mayoría de los usuarios pueden ver a distancias las maravillas de los lugares turísticos e interactuar con ellos de manera digital para luego hacerlo real.
La influencia del internet y su impacto en los adolescentes
Authors: Velasteguí Pablo Homero
Published: July 2019

Si bien sabemos la tecnología ha dado pasos agigantados en la actualidad, si recordamos como era en tiempos antiguos podemos notar los grandes cambios que han ido surgiendo gracias a la innovación constante que palpamos. La sociedad día a día está más con la tecnología, y es que nos hemos ido adaptando a todo aquello que ha surgido para beneficio nuestro, para agilizar tareas, las empresas gracias a los avances tecnológicos llevan su negocio más a la cumbre mencionando como un avance el internet pues en el podemos hacer cuanto podamos.

En el ámbito empresarial gracias al internet y ahora en la actualidad en muchas aplicaciones o de hecho al navegar encontramos muchos anuncios de empresas, de productos, entre otros, con la finalidad de poder dar a conocer a los usuarios los servicios que poseen las empresas, todo esto ha hecho posible surgir.

La tecnología si bien sabemos ha dado grandes cambios en beneficio de la sociedad, pero esta a su vez perjudica a los jóvenes porque hace que estén más pegados a ella y sientan la necesidad de estar siempre conectados a Internet ya sea enviando mensajes, viendo videos o a su vez gastando el tiempo en los videojuegos hasta cierto punto lo llamamos beneficioso, pero abusar de las tecnologías ya no es correcto por eso hay que tener un poco de concientización del tiempo y el uso que le estamos dando a estar en Internet.

Los jóvenes con facilidad se enredan en el mundo de la tecnología como ejemplo tenemos los celulares siempre quieren tener el más reciente y quieren mantenerse al día con la tecnología, pero de uno dependerá si queremos que esto nos cause una adicción o controlarlo.
Pecio buceo teseus, producto patrimonial subacuático en el destino Holguín
Authors: Gálvez Tamayo Yordanis , Cardet Fernández Evelina , Palao Fuentes Rosa
Published: July 2019

La actividad turística en Cuba hoy, deberá tener un crecimiento acelerado que garantice la sostenibilidad y dinamice la economía, incrementando de manera sostenida los ingresos y las utilidades, para ello, entre otras cosas, se continuará incrementando la competitividad del país en los mercados turísticos, a partir, principalmente, de elevar la calidad de los servicios con una adecuada relación calidad/precio y diversificando las ofertas, en tal sentido se puede apostar entre otras modalidades al desarrollo del turismo náutico . Entre los atractivos naturales del destino Holguín, que propician la práctica de deportes y excursiones náuticas, destacan las hermosas barreras coralinas de su litoral, en las cuales se puede disfrutar, según especialistas, del mejor buceo de paredes del país. Aunque existen ofertas a través de las cuales el visitante puede acceder al disfrute de fondos marinos de una riqueza única en el centro del Caribe, cada día el mercado actual exige algo más de aventura y productos novedosos, razón por la cual se desarrolló la presente investigación con el objetivo de diseñar el producto turístico Pecio Buceo Teseus para contribuir a la diversificación de la oferta del destino desde el Centro de Buceo Eagle Ray en Guardalavaca. Para alcanzar el objetivo propuesto se combinaron diferentes métodos y herramientas de investigación, entre las que se destacan la recolección y análisis de información, entrevistas, encuestas, observación y consulta a especialistas.
Role of bioactive molecules and maternal immune cells in breast milk in type 2 diabetes mellitus risk reduction
Authors: Yahaya Tajudeen , Sifau Mutiu
Published: July 2019

Inadequate breastfeeding or its total neglect has been mentioned in several studies as a contributing factor to the globally rising incidence of Type 2 diabetes mellitus (T2DM). However, the anti-diabetic role of breast milk has not been given much attention. As such, this study was initiated to review and bring to update on the role of breastfeeding in the risk reduction of T2DM. Relevant information on the topic was retrieved from the reliable science databases, including PubMed, MedLine, Google Scholar, Researchgate, etc. The results showed that breast milk is not energy dense and contains several health-enhancing bioactive molecules, including adipokines, antimicrobial and growth factors, cytokines, nutrients, and immune cells. Adipokines interact with the central nervous system to modulate certain physiological processes involved in energy balance, thereby programming an infant to be at a reduced risk for overweight, obesity and T2DM later in life. The antimicrobial and growth factors, as well as immune cells and bioactive nutrients may stimulate the growth of beneficial bacteria and/or inhibit the growth of pathogens. Thus, strengthen neonate defense mechanisms to effectively prevent infections as well as short and long-term disorders such as obesity and T2DM. In conclusion, nursing mothers are advised to breastfeed babies adequately before introducing them to complementary foods. To cater to the need of babies who may not have access to breastfeeding, healthcare providers should formulate infant formula using breast milk components as basic constituents.
Effect of 2, 4-D and Picloram on Somatic Embryogenesis in Carica papaya var. P-7-9
Authors: Chaudhary Kulbhushan , Prakash Jai
Published: July 2019

Immature zygotic embryos of Carica papaya L. var. P-7-9 were inoculated on half-strength MS with different concentrations of 2,4-D and picloram alone and their combinations. The highest induction (80%) of somatic embryogenesis was MS supplemented with 2,4-D (7.0 mg/l) followed by 2,4-D (4.0 mg/l) + picloram (1.0 mg/l) but no embryogenesis was observed in auxin-free medium. The addition of osmoticum such as PEG and ABA significantly increased the maturation of somatic embryos. BAP, TDZ and NAA were used for shoot induction. Combination of 2.0 mg/l BAP and 0.5 mg/l NAA was found significantly better for shoot bud proliferation and 70% multiplication. The percentage of germinating embryos was enhanced significantly when the MS fortified with GA3 (0.5 mg/l). However, the high frequency of embryo germination and plantlets formation were obtained with 2,4-D (4.0 mg/l) + picloram (1.0 mg/l).

Plant Tissue Cult. & Biotech. 29(1): 25-32, 2019 (June)
Plant Regeneration in Buckwheat (Fagopyrum esculentum Moench.) via Somatic Embryogenesis and Induction of Meristemoids in Abnormal Embryos
Authors: Saraswat Ribha , Kumar Mithilesh
Published: July 2019

An efficient in vitro regeneration protocol is reported for common buckwheat. A combination of 0.5 mg/l 2,4-D and 0.2 mg/l BAP with sucrose showed highest induction of somatic embryogenesis from cotyledon and hypocotyl explants. More than 35% of normal somatic embryos matured on MS. MS with 2% sucrose were found best for germination and conversion of somatic embryos to plantlets. In tissue culture, abnormal somatic embryos usually occur. In this report, abnormal embryos are also used to induce shoot organogenesis, adding to the number of final regenerants and ensuring full utilization of regenerative propagules. A treatment of 0.2 mg/l BAP induced meristemoids in 60% of underdeveloped embryos and a combination of 0.5 mg/l BAP and 0.5 mg/l AgNO3 led browning and senescence-free progression of shoot buds to well developed shoots, which were subsequently rooted in half strength MS containing 2% sucrose and 0.25 mg/l IBA. The regenerated plants survived acclimatization, flowered and set seeds.

Plant Tissue Cult. & Biotech. 29(1): 33-47, 2019 (June)