bluuebunny/crossref_metadata_2025 huggingface dataset:
An Update of the Efficacy and Comparative Characteristics of Direct
(New) Oral Anticoagulants (DOACs)
Authors: Karcioglu Ozgur , Yilmaz Sarper , Afacan Göksu , Ersan Eylem , Abuşka Derya , Zengin Sehmus , Ozkaya Bilgen , Hosseinzadeh Mandana , Yeniocak Selman
Published: September 2021

:

Direct (New-generation) Oral Anticoagulants (DOACs) have emerged as effective
agents which are used in place of vitamin-K antagonists in treatment and prophylaxis of Venous
Thromboembolism (VTE), atrial fibrillation and other thrombotic diseases. Among them, the FIIa-
direct thrombin inhibitor dabigatran and FXa inhibitors (rivaroxaban, apixaban, edoxaban) are
the most broadly used. Anticoagulant dosing may differ under special considerations. The patients’
physiological reserves, organ functional status and failures should be taken into account in clinical
decision-making processes. The advantages and drawbacks of each specific agent should be
weighed with special regard to metabolism, pharmacokinetics and pharmacodynamics, along with
the efficiency of the agents in different indications. This article aims to review the most recent literature
to highlight the usage and efficacy of the agents in different clinical conditions.
THE ROLE OF MEDIATION ON WORK SATISFACTION TO WORK ENVIRONMENT, TRAINING, AND COMPETENCY ON EMPLOYEE PERFORMANCE
Authors:   University of Dian Nuswantoro, Faculty of Economics and Business, Indonesia, Ingsih Kusni , Riskawati Nelis ,   University of Dian Nuswantoro, Faculty of Economics and Business, Indonesia, Prayitno Agus ,   University of Dian Nuswantoro, Faculty of Economics and Business, Indonesia, Ali Shujahat ,   Mirpur University of Science and Technology, Mirpur AJK, University of Science and Technology of China, Hefei China
Published: September 2021

This study aimed to determine the effect of work environment, training, and competence on work satisfaction in improving employee performance. The object in this study is PT. Asaputex Jaya, located in Tegal City, engaged in woven sarong’s trading business with the Korma Tree brand. The sample used in this study was determined by a simple random sampling method, obtaining 105 respondents. The data in this study were obtained through a questionnaire that was filled out independently. The analysis used in this study uses the analysis method of Structural Equation Modeling (SEM). This study proves and concludes that: work environment and work training have a significant positive effect on work satisfaction. However, competence does not affect work satisfaction. Besides, the work environment negatively affects employee performance, and work training does not affect employee performance. Also, competence and work satisfaction have a significant positive effect on employee performance. Further research must develop more varied models to provide different research findings, such as adding work stress variables, work motivation, work discipline, and others.
CO-SHOPPER, MALL ENVIRONMENT, SITUATIONAL FACTORS EFFECTS ON SHOPPING EXPERIENCE TO ENCOURAGE CONSUMERS SHOPPING MOTIVATION
Authors:   University of Jember, Indonesia, Wulandari Gusti Ayu , Suryaningsih Ika Barokah ,   University of Jember, Indonesia, Abriana Roshinta Meta ,   University of Jember, Indonesia
Published: September 2021

Motivation at a shopping Centres can be influenced by a pleasant shopping experience caused by other factors such as the role of companion, the shopping environment, and other situational factors. This study aims to determine the effect of co-shoppers, shopping environment, situational factors on shopping motivation through shopping experience in Jember Shopping Centres in the Covid-19 pandemic era. The population in this study are consumers who shop in all shopping Centres in Jember. The research sample is 125 respondents who are deemed sufficient to meet the requirements of the PLS analysis method of this study with purposive sampling methods. The results showed that the coshopper had no significant effect on the shopping experience; the shopping environment has a significant positive effect on the shopping experience; situational factors have no significant effect on the shopping experience. Co-shopper has a significant positive effect on shopping motivation. The shopping environment has no significant effect on shopping motivation. Situational factors have a significant positive effect on shopping motivation, and the Shopping Centre’s shopping experience has a significant positive effect on shopping motivation. Shopping Centres managers need to create an attractive and comfortable shopping environment to provide a pleasant shopping experience. Meanwhile, to increase shopping motivation, managers need to consider creating a comfortable atmosphere for coshoppers and creating co-conducive situational factors in increasing consumer shopping motivation in the shopping Centres they lead.
THE MEDIATING EFFECTS OF QUALITY OF WORK LIFE ON CAPACITY PERFORMANCE MANAGEMENT AND EMOTIONAL INTELLIGENCE
Authors:   Universitas Widyagama Malang, Indonesia, Hermawati Adya , Husin Husin ,   Universitas Halu Oleo Kendari, Indonesia, Sitorus Sunday Ade ,   STIE ITMI Medan, Indonesia, Djajanto Ludfi ,   Politeknik Negeri Malang, Indonesia, Bahri Syamsul ,   Universitas Widyagama Malang, Indonesia
Published: September 2021

This study evaluated the impact of leadership management skills and emotional intelligence on employee performance as a variable mediation through the quality of work life. This research uses a path analysis model (path analysis) since there is a mediation between the independent variables and the dependent variable to analyze the mediating impact of the quality of work-life on managerial leadership and emotional intelligence on employee efficiency. This analysis is called a universal survey (free sampling) or census using all population members, which amounts to 33 people. Management capacity led significantly to performance. Employee emotional intelligence also provides a valuable contribution to success. The standard of work has made a significant difference in the results. The managerial capability of the chief has made a positive contribution to the efficiency of the job. Employee emotional intelligence is also a positive contribution to job performance. K Quality in management, accompanied by the quality of work, has been a successful contribution to performance. Employee emotional intelligence was a positive contribution to results, followed by job efficiency. The study will contribute positively to the understanding of the job evaluation of BNN employees in Malang City. However, this analysis contributes to the assessment of BNN employees based on the job evaluation of BNN employees in Malang City. The difference between this study and previous studies is the treatment or care of Malang City BNN employees to improve the quality of their assessment.
THE EFFECT OF INFLATION, INTEREST RATE, AND EXCHANGE RATE ON STOCK RETURNS IN FOOD & BEVERAGES COMPANIES
Authors:   PGRI Adi Buana University Surabaya, Indonesia, Suharyanto Suharyanto , Zaki Achmad ,   Raden Rahmat Islamic University Malang, Indonesia
Published: September 2021

The purpose of this study was to determine the effect of technical information on stock returns partially. Risk and return are interrelated. The greater the return, the greater the risk obtained. However, if these risks are managed, the risks that will occur can be controlled properly. Several things need to be considered in making investment decisions, namely, by analyzing fundamental information and technical information, including inflation, exchange rates, interest rates, and their effect on stock returns. The method used in this study uses quantitative methods. This study indicates that inflation has a significant negative effect on stock returns, interest rates have no effect on stock returns, and the exchange rate has a significant negative effect on stock returns. Further researchers are expected to pay attention to the influence of other factors that can affect price movements and company stock returns.
THE FACTORS AFFECTING FINANCIAL PERFORMANCE IN MINING SECTOR COMPANIES 2014-2019 PERIOD
Authors:   Faculty of Economics, Universitas Negeri Surabaya, Indonesia, Taristy Dyana Novita , Hartono Ulil ,   Faculty of Economics, Universitas Negeri Surabaya, Indonesia
Published: September 2021

Financial performance is an assessment of the company from achieving predetermined targets. The aim of this research is the influence of leverage, firm size, capital structure, intellectual capital, and environmental cost towards the financial performance of Mining Sector Company listed on the Indonesian Stock Exchange (IDX) in 2014-2019. This research is included in the type of explanation research with quantitative research. Return On Assets (ROA) is used in this case to measure the company’s financial performance. In this research, the population consisted of 50 companies, and the obtained samples from the purposive sampling consisted of 10 companies. Multiple linear regression is used to be the analysis technique in this research. This research gets results that leverage, firm size, capital structure, and intellectual capital have not to effect on a company’s financial performance. The environmental cost has a significant negative effect on the company’s financial performance. The company must maintain the form of its responsibility to the environment by paying attention to the proportion of the budget that must be spent not to impact the acquisition of its financial performance. Next researcher can add or replace the variables that have been researched, replace or extend the period of the research year, increase the sample of companies, or use other sectors listed on the IDX as samples to get different results.
THE ROLE OF EMPLOYEE DEMOGRAPHICS, WORK STRESS, AND REWARDS ON JOB SATISFACTION AND EMPLOYEE PERFORMANCE
Authors:   Master Program in Management, Faculty of Management and Business Universitas Ciputra Surabaya, Ratri Kinanthi Gusti Reina , Wahjudono Denny Bernardus Kurnia ,   Faculty of Management and Business Universitas Ciputra Surabaya
Published: September 2021

This research was conducted at a private university in East Java (University X). The purpose of this study was to examine demographic factors as moderating variables on the relationship between job stress and job satisfaction and the relationship between rewards and job satisfaction and measure the effect of job satisfaction on job performance at the university. 106 administrative staff and 101 lecturers are the samples in this study. The sampling technique was employed using simple random sampling. Structural Equation Model used to analyze the multivariate data. Results showed that employee demographics of both respondents do not act as moderators on the relationship between job stress and job satisfaction and the relationship between rewards and job satisfaction. Likewise, the job satisfaction variable in this study does not provide a mediating effect on the relationship between job stress and employee performance and the relationship between rewards and employee performance. Significant results for administrative staff are shown in the relationship between rewards and job satisfaction and the relationship between rewards and employee performance. As for lecturers, significant results are shown in the relationship between job stress and performance and the relationship between reward and job satisfaction. Further research suggested conducting workload analysis for each position, developing an appropriate reward system, further research to determine the factors that can predict performance, and research continued by using unstructured demographic data, such as income levels or workloads.
EMPLOYEE ACHIEVEMENT IMPACT: PLACEMENT, COMPETENCY, AND MOTIVATION AS INTERVENING VARIABLES
Authors:   Universitas Mercu Buana Jakarta, Indonesia, Sukardi Sukardi , Aryanti Wiwin ,   Universitas Darma Persada Jakarta, Indonesia, Djumarno Djumarno ,   Universitas Mercu Buana Jakarta, Indonesia, Herminingsih Anik ,   Universitas Mercu Buana Jakarta, Indonesia, Kasmir Kasmir ,   Universitas Mercu Buana Jakarta, Indonesia
Published: September 2021

The purpose of this study was to determine the effect of placement and competence on work performance of permanent employees. Mediated by motivation in the welding section of the Automotive Industry in Tambun Bekasi. The research method used quantitative with a population of 125 employees. The number of samples used was 125 permanent employees in the Automotive Industry welding section in Tambun Bekasi. The sampling technique used was nonprobability sampling and the sampling method was saturated sampling. Then the analysis test was carried out using Structural Equation Modeling (SEM) and processed with the LISREL version 8.8 application. The results of this study indicate that placement and competence have a direct significant effect on work performance, while placement and competence through the intervening motivation variable have an effect on work performance, while motivation as an intervening variable has a significant effect on work performance. Subsequent research can be developed by adding variables of job design and physical conditions of work.
TOTAL QUALITY MANAGEMENT IN AFFECTING COMPANY OPERATIONAL PERFORMANCE IN CONVECTION SMEs WITH ORGANIZATIONAL COMMITMENT AS A MEDIATOR
Authors:   Management Department, Universitas Syiah Kuala, Indonesia, Putra Teuku Roli Ilhamsyah , Yunus Mukhlis ,   Management Department, Universitas Syiah Kuala, Indonesia, Fakhreza Teuku Hafiz ,   Management Department, Universitas Syiah Kuala, Indonesia
Published: September 2021

This study aims to prove the role of Total Quality Management (TQM) and organizational commitment in supporting the achievement of company operational performance. The population was all Convection SMEs in the city of Banda Aceh, consisted of 294 Convection SMEs. The sample was selected using a proportional sampling technique where sampling considers elements or categories in the study population. The sample taken was 15% of the population. One respondent represented one unit of SMEs, so the sample has amounted to 169 respondents. Data was collected using questionnaires. The model was analyzed with the Structural Equation Model Analysis. The result showed an influence between TQM on Organizational Commitment, TQM on Company Operational Performance, and Organizational Commitment on Company Operational Performance. This study also found that organizational commitment can act as a partial mediator to strengthen the effect of TQM on Company operational performance. The interesting issue in this study lies in the discussion of the organizational commitment to solving the inconsistency problems in the quality of convection production in SMEs. Furthermore, the other researchers can provide more concepts and variables to enrich this research model, like other mediators for TQM to achieve performance or even the commitment that can strengthen the TQM and performance. The model also can be a reference for practitioners to set their strategy in further, to go more productive.
Tecnologías simbólicas y culturas creativas
Authors: Molina Garrido Germán Andrés
Published: September 2021

Este libro recoge, analiza y expone en un lenguaje pedagógico cuatro momentos del proceso señalado en el subtítulo: el contexto de los municipios sujeto-objeto de intervención, Clemencia y María la Baja, en Bolívar; qué fueron en la práctica estos laboratorios más allá de las definiciones previas; cómo funcionaron, y qué impactos y recomendaciones de política pública se pueden extraer de su implementación. El lector puede conocer de primera mano cuáles fueron los mecanismos a través de los cuales operaron los Laboratorios Vivos de Innovación y Cultura, que, gracias a la conjunción de la voluntad política de la Gobernación de Bolívar, del Instituto de Cultura y Turismo de Bolívar (Icultur), de la Universidad de Bogotá Jorge Tadeo Lozano, Seccional del Caribe, y a la interventoría de la Universidad Tecnológica de Bolívar, fueron posibles por su aprobación dentro del Fondo de Ciencia, Tecnología e Innovación en el marco del Sistema General de Regalías (SGR).
Employers’ Perceptions in Hiring Decisions Pertaining to People with Disability
Authors: Mat Yusoff Norhayati , Saripin Sofia Sarmimi , Muhammad Rosmaliza , Sudono Agus
Published: September 2021

This study aims to analyse hotels employers’ perceptions in hiring decisions on people with disability (PWD). A total of 35 samples out of 72 employers among the 4 and 5-star hotels in Kuala Lumpur were selected based on the census sampling method. It is found that employer perceptions to hire PWDs are influenced by gender, type of disability, work performance concerns, and co-worker and guest concerns. Interestingly, employers are discovered to have more positive perceptions towards female PWDs. They are also interested to hire PWDs who meet the requirements of the job regardless of their disability.
Factors Contributing to Depression and Cognitive Impairment Among Patients on Hemodialysis
Authors: Nasution Raduan Nor Jannah , Ali Nur Faizah , Amalia Emmy , Salleh Mohd Razali
Published: September 2021

Depression and cognitive impairment are the most common complications of patients on hemodialysis. The objective of this study is to identify contributing factors to depression and cognitive impairment in hemodialysis patients. This is a cross-sectional study involving 110 hemodialysis patients in Hospital Kuala Lumpur. The samples were recruited through universal sampling. Patients were assessed with Beck Depression Inventory and Montreal Cognitive Assessment. This study found that 18.2% patients had depression and 48.2% had cognitive impairment. Factors associated with depression were unmarried status, low education level and cognitive impairment. Factors associated with cognitive impairment were low education level, depression and unemployment.
Focus Group Discussions with Young People on Premarital Sex and its Consequences
Authors: Razali Salmi , Sham Fatimah , Dasiman Razif , Mohamed Noor Khan Nor Ashikin
Published: September 2021

Six focus group discussions were conducted among 59 young people to explore the possible factors of premarital sex, ex-nuptial pregnancy, and infant abandonment. Thematic analysis revealed three factors associated with the social crises; i)‘adjustment with the transition in life’- young people described living in a dilemma between the strong urge for more freedom in sexuality and adherence to religious teaching; ii)' conflict in relationships with parents and peers - receptive versus harsh and punitive parenting style and romantic peers relationship versus self-isolation, and iii)' lacking internal defences' - poor religiosity and lack of psychological skills including self-efficacy and self-control.
Mobile-Assisted Language Learning (MALL) in Language Learning
Authors: Tengku Paris Tengku Nazatul Shima , Abdul Manap Nurma , Abas Hafiza , Ling Lo Mun
Published: September 2021

This is a case study using an interactive digital game to teach grammar via Mobile Assisted Language Learning (MALL). The interactive game via MALL is aimed to ease TESL students' fear and trigger their interest in learning grammar. The game uses the Theory of Variation (Marton & Booth) to design the grammar exercises in the game. A survey questionnaire and a semi-structured interview were administered to gauge the students’ perceptions of using the game. The findings show that the game has somewhat improved students’ grammar knowledge.
Просветляющие покрытия на основе ZnO, полученные методом электронно-лучевого испарения
Authors: Марков Л.К. , Павлюченко А.С. , Смирнова И.П.
Published: September 2021

In this work, research was carried out to analyze the possibility to fabricate nanostructured antireflection coatings based on ZnO. The dependence of structural features of the film on the substrate heating temperature during deposition of an aluminum-doped zinc oxide (AZO) has been studied. It is shown that it is impossible to obtain the required structural properties of the film by changing one parameter, the substrate temperature during deposition of the material, in the range of 20 – 600 °C. For this purpose, an approach has been suggested, which consists in preliminary deposition of a nanometer-thick Sn layer with subsequent substrate heating up to the temperature of deposition of the main material layer. The optimization of coating deposition conditions led to the fabrication of a medium consisting of many whiskers with transverse dimensions of tens of nanometers and a length of hundreds of nanometers, which are oriented mainly perpendicular to the substrate. It is shown that the gradient nature of a change in the material density, and, hence, in the effective refractive index in the direction perpendicular to the substrate plane, provides antireflection properties of the coating over a wide range of wavelengths as well as in different directions of light propagation.
Квантовые осцилляции магнетосопротивления в гетероструктурах HgCdTe/HgTe/HgCdTe с инвертированным зонным спектром
Authors: Боголюбский А.С. , Гудина С.В. , Неверов В.Н. , Туруткин К.В. , Подгорных С.М. , Шелушинина Н.Г. , Якунин М.В. , Михайлов Н.Н. , Дворецкий C.А.
Published: September 2021

The effects observed in the Shubnikov - de Haas oscillation regime in the HgCdTe/HgTe/HgCdTe heterostructure with a wide (20.3 nm) HgTe quantum well with an inverted band structure are discussed. In a topologically trivial 2D system, Pi(Greek letter) - shift of magnetooscillation phase is found. A thorough experimental study and theoretical analysis of the data is presented to understand the physical causes of this anomalous phase shift. The value of the effective electron mass m_c/m_0 = (0.022+-0.002), obtained from the region of doubly degenerate peaks of magnetoresistance, is approximately half the theoretical estimates. In the region of stronger magnetic fields for nondegenerate peaks of magnetoresistance, we have m_c/m_0 = (0.034+-0.003), which is in good agreement with both theoretical predictions and experimental results obtained from the analysis of activation conductivity in the quantum Hall effect regime. The reasons for this discrepancy are discussed.
Słownik analityczny do Biblii greckiej
Authors: Mazur Roman , Bogacz Roman
Published: September 2021

Hasłami słownika są ułożone alfabetycznie formy podstawowe wszystkich terminów występujących w Biblii greckiej. Następnie w każdym haśle podane jest znaczenie terminu greckiego w języku polskim oraz liczba jego wystąpień w Septuagincie, w tekstach paralelnych i w Nowym Testamencie oraz suma wszystkich wystąpień terminu w całym Piśmie Świętym. Na końcu każdego hasła w porządku alfabetycznym podano wszystkie formy danego terminu występujące w Biblii. Każda z tych form ma pełne objaśnienie gramatyczne, po którym wskazane są wszystkie miejsca jej występowania w całym Piśmie Świętym. Słownik analityczny do Biblii greckiej został opublikowany w wersji drukowanej (wersja drukowana do nabycia na stronie Wydawnictwa UNUM) w trzech tomach z ciągłą numeracją stron oraz w wersji online w formacie PDF w jednym pliku (wersja PDF do nabycia na stronie Wydawnictwa UNUM).
Pełna konkordancja do Biblii greckiej
Authors: Mazur Roman , Bogacz Roman
Published: September 2021

Pełna konkordancja do Biblii greckiej jest bardzo obszerna – jej objętość to około 3 tysięcy arkuszy wydawniczych, dlatego opublikowana została tylko w wersji online w formacie PDF w 24 plikach (liczba plików odpowiada liczbie liter alfabetu greckiego), co w znacznym stopniu ułatwia poszukiwanie określonych terminów. W konkordancji tej wyrazy zostały uporządkowane według alfabetu greckiego, a uporządkowanie alfabetyczne obejmuje zarówno termin poszukiwany, jak i kontekst obustronny. Wprawdzie wydawane wcześniej konkordancje były ułożone również w porządku alfabetycznym – terminy poszukiwania podawano według alfabetu, ale już teksty biblijne, w których dany termin występuje, podawano w porządku kanonicznym, to znaczy według kolejności ksiąg biblijnych. W Pełnej konkordancji do Biblii greckiej alfabetycznie uporządkowane są nie tylko terminy, ale także fragmenty tekstów biblijnych. Podawany jest kontekst poprzedzający i następujący poszukiwanego terminu. Dzięki temu można od razu odnaleźć cytaty występujące w Biblii, parafrazy oraz inne podobne do siebie fragmenty, np. dotyczące tego samego tematu. Jest to konkordancja tekstowa, dlatego też wszystkie terminy podane są w formach, które występują w tekście.
Energy Storage and Installed Wind Capacity Requirements for the Substitution of Fossil Fuels in the Electricity Generation Sector
Authors:   Dept. of Engineering, TCU, Fort Worth, TX, 76132, USA, Michaelides Efstathios E.
Published: September 2021

The impending adverse effects of Global Climate Change encourages the substitution of fossil fuels with non-carbon sources for electricity generation. However, while fossil fuel power plants may generate electric power at demand, the most abundant renewable energy sources–wind and solar–are intermittent or periodically variable. This necessitates the development of adequate energy storage at the utility/grid level. Using actual data for the hourly energy demand in the ERCOT electricity grid, this study examines the electricity supply-demand equilibrium and determines the necessary energy storage capacity for the substitution, first, of the coal power plants and, secondly, of all the fossil fuel power plants. The calculations show that, if the natural gas, intermediate-load power plants continue to be available, all coal units may be substituted with wind farms without the need for energy storage. When all the fossil fuel units are to be substituted, significant energy storage capacity is required, approximately 45.3 million m3. The calculations also show that the further development of nuclear energy and additional solar energy units reduce the requirements for energy storage and, also lessen the energy dissipation in the storage-recovery process.
The National COVID Cohort Collaborative: Analyses of Original and Computationally Derived Electronic Health Record Data
Authors: Foraker Randi , Guo Aixia , Thomas Jason , Zamstein Noa , Payne Philip RO , Wilcox Adam ,   N3C Collaborative
Published: September 2021

Background

Computationally derived (“synthetic”) data can enable the creation and analysis of clinical, laboratory, and diagnostic data as if they were the original electronic health record data. Synthetic data can support data sharing to answer critical research questions to address the COVID-19 pandemic.

Objective

We aim to compare the results from analyses of synthetic data to those from original data and assess the strengths and limitations of leveraging computationally derived data for research purposes.

Methods

We used the National COVID Cohort Collaborative’s instance of MDClone, a big data platform with data-synthesizing capabilities (MDClone Ltd). We downloaded electronic health record data from 34 National COVID Cohort Collaborative institutional partners and tested three use cases, including (1) exploring the distributions of key features of the COVID-19–positive cohort; (2) training and testing predictive models for assessing the risk of admission among these patients; and (3) determining geospatial and temporal COVID-19–related measures and outcomes, and constructing their epidemic curves. We compared the results from synthetic data to those from original data using traditional statistics, machine learning approaches, and temporal and spatial representations of the data.

Results

For each use case, the results of the synthetic data analyses successfully mimicked those of the original data such that the distributions of the data were similar and the predictive models demonstrated comparable performance. Although the synthetic and original data yielded overall nearly the same results, there were exceptions that included an odds ratio on either side of the null in multivariable analyses (0.97 vs 1.01) and differences in the magnitude of epidemic curves constructed for zip codes with low population counts.

Conclusions

This paper presents the results of each use case and outlines key considerations for the use of synthetic data, examining their role in collaborative research for faster insights.
Perspectives From French and Filipino Parents on the Adaptation of Child Health Knowledge Translation Tools: Qualitative Exploration (Preprint)
Authors: Elliott Sarah A , Wright Kelsey S , Scott Shannon D , Hartling Lisa
Published: September 2021

BACKGROUND

A number of evidence-based knowledge translation (KT) tools for parents of children with acute health conditions have been developed. These tools were created and tested with parental input and disseminated to groups proficient in English. Therefore, it is unclear whether they are useful for populations that are more diverse. To enhance the reach of our current and future KT tools, language translation and cultural adaptations may promote relevance for previously underserved knowledge users.

OBJECTIVE

This study aims to explore and understand considerations for the cultural and linguistic adaptation of a KT tool in French and Filipino communities.

METHODS

A KT tool (whiteboard animation video) describing the signs and symptoms of croup was originally developed in English to provide parents with evidence-based information couched within a narrative reflecting parents’ experiences with the condition. This KT tool was adapted (linguistics and imagery) for French- and Tagalog-speaking parents and caregivers through feedback from key stakeholders. The videos were presented to the respective language speakers for usability testing and discussion. Participants were asked to view the KT tool, complete a usability survey, and participate in semistructured interviews. Audio recordings from the interviews were transcribed verbatim, translated into English, and analyzed for relevant themes by using thematic analysis.

RESULTS

French- (n=13) and Tagalog-speaking (n=13) parents completed the usability survey and were interviewed. Although analyzed separately, both data sets produced similar findings, with key themes relating to understanding, relatability, and accessibility. Both the French and Tagalog groups reported that the video and other KT tools were useful in their adapted forms. Participants in both groups cautioned against using verbatim vocabulary and suggested that cultural competency and understanding of health languages were essential for high-quality translations. Parents also discussed their preference for videos with diverse visual representations of families, home environments, and health care workers, as such videos represent their communities more broadly.

CONCLUSIONS

French and Filipino parents appreciated having KT tools in their first language; however, they were also supportive of the use of English KT products. Their suggestions for improving the relatability and communication of health messages are important considerations for the development and adaptation of future KT products. Understanding the needs of the intended end users is a crucial first step in producing relevant tools for health evidence dissemination.
Information-Seeking Behavior of Community Pharmacists in Japan during the COVID-19 Pandemic: An Ecological Study Based on Indexing Web Page Access (Preprint)
Authors: Suzuki Shota , Nishikawa Yoshitaka , Okada Hiroshi , Nakayama Takeo
Published: September 2021

BACKGROUND

The COVID-19 pandemic has caused an infodemic, and the need for rapid and accurate information seeking and providing has become an urgent issue. Community pharmacies play an important role in supporting the health of residents as “Communicators”. In the early stages of the pandemic in Japan, there was a lack of information in pharmacies about infection control written in Japanese. Therefore, the Pharmacy Informatics Group (Kyoto, Japan) published a Japanese-language web page to disseminate this information. Nevertheless, the information-seeking behavior of Japanese pharmacists during disasters such as COVID-19 has not been fully evaluated.

OBJECTIVE

This study aims to evaluate the information-seeking behavior of community pharmacists during the COVID-19 pandemic, with relation to COVID-19 infections and deaths within their local prefecture.

METHODS

An ecological study comparing the number of accesses to the web page established by the Pharmacy Informatics Group and the number of infections and deaths in 47 prefectures was conducted. Total number of accesses (TA), total number of infections (TI) per 100,000 population, total number of deaths (TD) per 100,000 population, and number of pharmacists per 100,000 population for the 47 prefectures during the target period (April 6 to September 30, 2020) were calculated using the access information on the web page and public information.

RESULTS

In Japan, during the first 6 months of the COVID-19 pandemic, TA was 226,130 (10,984–138,898), TI was 78,761 (1,738–31,857), and TD was 1,470 (39–436). The correlation between TA and TI per 100,000 population in 47 prefectures was r=.72 (95% CI: .55–.83, P<.001), and between TA and TD per 100,000 population in 47 prefectures was r=.44 (95% CI: .17–.65, P=.002).

CONCLUSIONS

Our findings indicate that information-seeking behavior of community pharmacists was positively correlated with infection status within the community.
The clinical desire for pressurized intraperitoneal aerosol chemotherapy in South Korea: An electronic survey-based study (Preprint)
Authors: Lee Eun Ji , Park Soo Jin , Lee Jeesun , Mun Jaehee , Paik Haerin , Seol Aeran , Kim Junhwan , Yim Ga Won , Shim Seung-Hyuk , Kim Hee Seung , Chang Suk-Joon
Published: September 2021

BACKGROUND

Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is effective for treating solid tumors with peritoneal metastasis. However, PIPAC is not a standard treatment globally and is currently only used in the limited areas.

OBJECTIVE

We performed a survey of surgical oncologists related to PIPAC to evaluate the clinical desire for PIPAC in South Korea, one of the many countries where PIPAC has not yet been introduced.

METHODS

We performed an online survey between November and December 2019. The questionnaire consisted of 20 questions, which were divided into comprehensive, procedure, and cost inquiries including five, 13 and two questions, respectively.

RESULTS

A total of 164 respondents who answered the questionnaire. Among respondents, 41.7-50% majoring in ovarian cancer, pseudomyxoma peritonei, and malignant mesothelioma preferred PIPAC for the curative treatment of primary diseases, whereas 32.7-33.3% majoring in colorectal and hepatobiliary cancers chose it for the palliative treatment of recurrent diseases. Moreover, 66.7-95.2% considered PIPAC appropriate for the cancers the specialized in, and 76-78.7% expected a treatment response of more than 50% and considered grade 1 or 2 minor surgical complications acceptable. Finally, most of the respondents answered the reasonable costs to purchase and implement PIPAC once at between 1,000,000-5,000,000 KRW.

CONCLUSIONS

Although the treatment scope for applying PIPAC was different among Korean surgical oncologists, most of them expected relatively high tumor response rates with minor toxicities through the repeated implementation of PIPAC.
VALIDATED AND QUANTIFIED STABILITY INDICATING STRESS DEGRADATION STUDY OF ORAL ANTI-DIABETIC AGENT CANAGLIFLOZIN BY RP-HPLC METHOD
Authors: MURUGESAN ARULSELVAN , MATHRUSRI ANNAPURNA MUKTHINUTHALAPATI
Published: September 2021

Objective: The present investigation is aimed to develop and validate, a simple, consistent and sensitive stability-indicating reverse phase-high performance liquid chromatography (RP-HPLC) method for the determination of oral anti-diabetic drug Canagliflozin in bulk and pharmaceutical dosage form as per the International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH-Q2 (R1)).
Methods: The chromatographic separation was achieved by using Reverse Phase-High Performance Liquid Chromatography (RP-HPLC) ZORBAX C18 (250 mm x 4.6 mm, 5μm particle size) with a mobile phase consisting of Acetonitrile: Water in a ratio of 53:47% v/v at a flow rate of 1 ml/min with an injection volume of 20 μl.
Results: The Retention time of the drug Canagliflozin was found to be 2.36±0.05 min and detected at 214 nm UV wavelength. The linear regression equation was found to be y = 60702x–2156.2 with a correlation coefficient 0.9999. Stress degradation studies were performed by exposing the Canagliflozin into acidic, alkaline, oxidative, thermal and photolytic stress conditions with active samples withdrawn at different time intervals as per ICH guidelines.
Conclusion: The proposed Reverse Phase High-Performance Liquid Chromatography (RP-HPLC) method was found to be robust, precise and specific for estimation of Canagliflozin in pharmaceutical dosage forms.
FORMULATION AND EVALUATION OF TOPICAL NANOEMULGEL OF METHOTREXATE FOR RHEUMATOID ARTHRITIS
Authors: DAS SAHELI , M. SHARADHA , VENKATESH M. P. , SAHOO SUBHASHREE , TRIPATHY JOGABRATA , GOWDA D. V.
Published: September 2021

Objective: The purpose of this study was to develop and evaluate methotrexate-loaded nanoemulgel for topical delivery in the management of rheumatoid arthritis.

Methods: Based on nanoemulsion composition, the pseudo ternary phase diagram was fabricated by using peanut oil, Tween 20 as the surfactant, and PEG 400 being used as a co-surfactant. The methotrexate-loaded nanoemulsion was formulated by using the spontaneous emulsification method. Badam gum was used as a gel matrix in the prepared nanoemulsion to form nanoemulgel. The methotrexate loaded nanoemulgel was characterized and evaluated for pH, particle size, physical appearance, viscosity, spreadability, TEM, drug content, diffusion study, release kinetics, and stability studies.

Results: The nanoemulgel constituting 8.6% peanut oil, 34.4% of Tween 20 and PEG 400 as Smix (surfactant and co-surfactant mixture), 43% water, and 12.5% w/w badam gum was concluded as optimized formulation. The prepared nanoemulgel was translucent in nature having a particle size of 195.1nm and zeta potential of -0.278mV. Drug content and drug release for the optimized formulation were found to be 98.11±0.34% and 95.11±0.02% respectively. pH, viscosity, and spreadability were found to be optimum. Stability study data showed that the prepared nanoemulgel was stable at different temperatures varying from -25 to +45ºC.

Conclusion: Methotrexate loaded nanoemulgel has been formulated for topical drug delivery for the management of rheumatoid arthritis.
FABRICATION AND CHARACTERIZATION OF FAST DISSOLVING FILMS OF ECLIPTA PROSTRATE LEAVES EXTRACT TO TREAT MOUTH ULCERS
Authors: S. S. MANIKIRAN , PRIYA NAGAM SANTHI , MOLLY B. AUBINE , NORI LAKSHMI PRASANTHI
Published: September 2021

Objective: This research focused on the design of fast dissolving herbal film of Eclipta Prostrate leaves extract for mouth ulcers.
Methods: The extract of Eclipta Prostrata leaves was formulated as films by solvent casting method using various polymers viz., HPMC E5, HPMC E15, sodium alginate and PVA. The films were designed by using propylene glycol as a plasticizer, SSG as super disintegrate and honey as a sweetener. Furthermore, the films were evaluated for thickness, folding endurance, weight variation, % elongation, surface pH, % moisture uptake, % moisture loss, disintegration and in vitro drug release study.
Results: The revealed that all the films were good in appearance and had a smooth texture. Out of all ten formulations, F3 and F5 disintegrated rapidly with a disintegration time of 27 and 32 seconds. The drug release studies revealed that all the formulations had a good release profile, but the F3 formulation showed rapid release i.e. 83.57% in 4 min. The stability studies revealed that the formulations F3 and F5 were found good with non-tackiness, easily separable and disintegrated at 29 and 33 sec respectively with no appearance and drug release.
Conclusion: The research revealed that Eclipta prostrate leaves extract can be formulated into oral films for the treatment of mouth ulcers with improved bioavailability and expected patient compliance.
PHARMACEUTICAL AND BIOPHARMACEUTICAL ASPECTS OF QUANTUM DOTS-AN OVERVIEW
Authors: SHAIKH SADDAM C. , SABOO SHWETA G. , TANDALE PRASHANT S. , MEMON FAHIM S. , TAYADE SHARAD D. , HAQUE M. AKIFUL , KHAN SHARUK L.
Published: September 2021

In the twenty-first century, nanotechnology has become cutting-edge technology. It is interdisciplinary and multidisciplinary, covering numerous fields such as medicine, engineering, biology, physics, material sciences, and chemistry. The present work aims to cover the optical properties, method of preparations, surface modifications, bio-conjugation, characterization, stability, and cytotoxicity of quantum dots (QDs).
Articles were reviewed in English literature reporting the pharmaceutical and bio-pharmaceutical aspects of QDs which were indexed in Scopus, web of science, google scholar and PubMed without applying the year of publication criterion.
One significant value of utilizing nanotechnology is that one can alter and control the properties in a genuinely unsurprising way to address explicit applications' issues. In science and biomedicine, the usage of functional nanomaterials has been broadly investigated and has become one of the quick-moving and stimulating research directions. Different types of nanomaterial (silicon nanowires, QDs, carbon nanotubes, nanoparticles of gold/silver) were extensively utilized for biological purposes. Nanomedicine shows numerous advantages in the natural characteristics of targeted drug delivery and therapeutics. For instance, protection of drugs against degradation, improvement in the drug's stability, prolonged circulation time, deceased side effects, and enhanced distribution in tissues. The present review article deals with the quantum dots, their optical properties, method of preparations, surface modifications, bio-conjugation, characterization, stability, and cytotoxicity of quantum dots. The review also discusses various biomedical applications of QDs.
The QDs-based bio-nanotechnology will always be in the growing list of unique applications, with progress being made in specialized nanoparticle development, the detection of elegant conjugation methods, and the discovery of new targeting ligands.
BIO-ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF DECITABINE AND CEDAZURIDINE IN HUMAN PLASMA USING LC-MS/MS
Authors: N. SAI PRUDHVI , B. S. VENKATESWARLU , M. V. KUMUDHAVALLI , V. MURUGANANTHAM
Published: September 2021

Objective: The present work aimed to develop a novel, reliable and accurate Liquid Chromatography-Mass Spectrometry/Mass spectrometry (LC-MS/MS) method for the simultaneous quantification of Decitabine and Cedazuridine a combined medication used for the treatment of chronic myelomonocytic leukemia in human plasma.
Methods: Talazoparib drug is used as an internal standard in the study. Both the analytes and internal standard were isolated from 100 ml plasma samples by liquid-liquid extraction and then chromatographed on Zorbax SB-CN (4.6 mm×75 mm, 3.5 µm) column with a mobile phase consisting of 0.1 % ammonium formate and methanol in the ratio of 65:45 (v/v) pumped at 0.5 ml/min. The method had a chromatographic total run time of 5 min.
Results: The developed method gave a symmetric peak at a retention time of 1.7 min for Decitabine, 2.2 min for Cedazuridine, 3.5 min for Talazoparib and satisfied all the peak properties as per USP guidelines. The mass spectral characterization of separated analytes in the LC method was performed using a mass detector operated at Multiple Reaction Monitoring mode with precursor-to-product ion transitions at m/z of 229 to m/z of 114 as MH+ion for Decitabine, m/z of 269 to m/z of 118 as MH+ion for Cedazuridine. A very sensitive limit of detection of 0.3 ng/ml was observed and showed a calibration curve linear over the concentration range of LLOQ (lower limit of quantification) to 500 ng/ml. The other validation parameters were found to have acceptable accuracy, precision, linearity, and selectivity. The mean extraction concentration was acceptable and very high for both the analytes in HQC (high-quality control concentration), MQC (medium quality control concentration) and LLOQ levels. The peak area response ratio of Decitabine and Cedazuridine with the internal standard in freeze-thaw, short term and long term stability studies was found to be acceptable confirms that the method is stable.
Conclusion: It can be concluded that the proposed method is specific, accurate, and precise and could be used for the simultaneous estimation of Decitabine and Cedazuridine in human plasma.
THE EVALUATION OF ACTIVITY AND STABILITY OF ISOLATED BROMELAIN FROM PINEAPPLE CORES (ANANAS COMOSUS [L.] MERR) AND IN VITRO PENETRATION TEST OF NANOEMULSION TOPICAL BASE
Authors: ROHMAH AINUR , PRABOWO HEGI ADI , SETIASIH SISWATI , HANDAYANI SRI , JUFRI MAHDI , HUDIYONO SUMI
Published: September 2021

Objective: Oral administration of bromelain as an anti-inflammation therapy still faces several challenges, such as the risk of contact with the gastric fluid and its low absorption rate. Therefore, bromelain isolated from the pineapple core will be formulated as a topical base in a nanoemulsion to increase its stability, activity, and ability to penetrate the skin.
Methods: Bromelain was isolated from pineapple core using ammonium sulfate precipitation and dialysis, and then the isolated fraction was loaded into topical nanoemulsion for subsequent evaluation of its characteristics, stability, enzymatic activity, and for in vitro study of penetration using Franz diffusion cell.
Results: The highest specific activity of bromelain fractions found in ammonium sulfate concentration is around 20–50%. After being dialyzed, the bromelain fraction showed an increase in specific activity 2.78-fold as compared to crude extract. The characteristics of bromelain nanoemulsion showed a globule size of 21.37±1.8 nm with a polydispersity index (pdI) 0.323±0.049, oil in water (o/w) type, and the type of rheology was plastic flow. The nanoemulsion stability base was observed, and there was no phase separation after centrifugation. Bromelain in nanoemulsion base showed a proteolytic activity of 5.00 U/ml with a protein content of 154.28 mg/l. In vitro penetration studies using Franz diffusion cell for 8 h showed isolated bromelain in nanoemulsion base has a total cumulative number value of 1386.94 μg/cm2 with penetrated velocity/flux (J) of 45.93 μg/cm2 h.
Conclusion: The results showed promise for bromelain loaded into nanoemulsion as a vehicle for topically administered therapeutic enzymes.
QBD APPROACH TO ANALYTICAL METHOD DEVELOPMENT AND ITS VALIDATION FOR ESTIMATION OF LENVATINIB IN BULK AND PHARMACEUTICAL FORMULATION
Authors: BABAR SACHIN A. , L. PADWAL SUDHAKAR
Published: September 2021

Objective: The objective of this research was to develop a simple, very rapid, sensitive, accurate, precise reverse phase High-Performance Liquid Chromatography (RP-HPLC) technique for the estimation of Lenvatinib in bulk and its dosage form.
Methods: To perform this study, we employed a central composite design (CCD) to make method robust and effective to create chromatographic database. The factor screening studies were performed using 2-factor 10-runs. The factors were selected as the mobile phase ratio and buffer pH.
Results: The desirability value of the optimized model was found to be 0.869 and The optimized chromatographic condition was achieved on Enable C18 analytical column with 0.01M Ammonium acetate buffer pH 3.84: methanol (33.17:66.83 v/v) as the mobile phase and flow rate of 1 ml min-1 and detection wavelength was set to 240 nm. The retention time of Lenvatinib was found to be 5.122 min. Linearity was established for Lenvatinib in the range of 10-50 µg/ml with a correlation coefficient (r2=0.9995). The accuracy values were found to be in the range of 98–102%. Intraday precision and Interday precision were in prescribed (Less than 0.98% RSD). Robustness was found to be less than 1.22% RSD.
Conclusion: The proposed method was useful for best analysis of Lenvatinib in Bulk pharmaceutical dosage forms. Central Composite Design was an effective tool for the proposed RP-HPLC method.