bluuebunny/crossref_metadata_2025 huggingface dataset:
Elevation of NO production increases Fe immobilization in the Fe-deficiency roots apoplast by decreasing pectin methylation of cell wall
Authors: Ye Yi Quan , Jin Chong Wei , Fan Shi Kai , Mao Qian Qian , Sun Cheng Liang , Yu Yan , Lin Xian Yong
Published: June 2015

Cell wall is the major component of root apoplast which is the main reservoir for iron in roots, while nitric oxide (NO) is involved in regulating the synthesis of cell wall. However, whether such regulation could influence the reutilization of iron stored in root apoplast remains unclear. In this study, we observed that iron deficiency elevated NO level in tomato (Solanum lycopersicum) roots. However, application of S-nitrosoglutathione, a NO donor, significantly enhanced iron retention in root apoplast of iron-deficient plants, accompanied with a decrease of iron level in xylem sap. Consequently, S-nitrosoglutathione treatment increased iron concentration in roots, but decreased it in shoots. The opposite was true for the NO scavenging treatment with 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (cPTIO). Interestingly, S-nitrosoglutathione treatment increased pectin methylesterase activity and decreased degree of pectin methylation in root cell wall of both iron-deficient and iron-sufficient plants, which led to an increased iron retention in pectin fraction, thus increasing the binding capacity of iron to the extracted cell wall. Altogether, these results suggested that iron-deficiency-induced elevation of NO increases iron immobilization in root apoplast by decreasing pectin methylation in cell wall.
Differential monocular vs. binocular pupil responses from melanopsin-based photoreception in patients with anterior ischemic optic neuropathy
Authors: Tsika Chrysanthi , Crippa Sylvain V. , Kawasaki Aki
Published: June 2015

We examined the effect of anterior ischemic optic neuropathy (AION) on the activity of intrinsically photosensitive retinal ganglion cells (ipRGCs) using the pupil as proxy. Eighteen patients with AION (10 unilateral, 8 bilateral) and 29 age-matched control subjects underwent chromatic pupillometry. Red and blue light stimuli increasing in 0.5 log steps were presented to each eye independently under conditions of dark and light adaptation. The recorded pupil contraction was plotted against stimulus intensity to generate scotopic and photopic response curves for assessment of synaptically-mediated ipRGC activity. Bright blue light stimuli presented monocularly and binocularly were used for melanopsin activation. The post-stimulus pupil size (PSPS) at the 6th second following stimulus offset was the marker of intrinsic ipRGC activity. Finally, questionnaires were administered to assess the influence of ipRGCs on sleep. The pupil response and PSPS to all monocularly-presented light stimuli were impaired in AION eyes, indicating ipRGC dysfunction. To binocular light stimulation, the PSPS of AION patients was similar to that of controls. There was no difference in the sleep habits of the two groups. Thus after ischemic injury to one or both optic nerves, the summated intrinsic ipRGC activity is preserved when both eyes receive adequate light exposure.
Processes driving nocturnal transpiration and implications for estimating land evapotranspiration
Authors: de Dios Víctor Resco , Roy Jacques , Ferrio Juan Pedro , Alday Josu G. , Landais Damien , Milcu Alexandru , Gessler Arthur
Published: June 2015

Evapotranspiration is a major component of the water cycle, yet only daytime transpiration is currently considered in Earth system and agricultural sciences. This contrasts with physiological studies where 25% or more of water losses have been reported to occur occurring overnight at leaf and plant scales. This gap probably arose from limitations in techniques to measure nocturnal water fluxes at ecosystem scales, a gap we bridge here by using lysimeters under controlled environmental conditions. The magnitude of the nocturnal water losses (12–23% of daytime water losses) in row-crop monocultures of bean (annual herb) and cotton (woody shrub) would be globally an order of magnitude higher than documented responses of global evapotranspiration to climate change (51–98 vs. 7–8 mm yr−1). Contrary to daytime responses and to conventional wisdom, nocturnal transpiration was not affected by previous radiation loads or carbon uptake and showed a temporal pattern independent of vapour pressure deficit or temperature, because of endogenous controls on stomatal conductance via circadian regulation. Our results have important implications from large-scale ecosystem modelling to crop production: homeostatic water losses justify simple empirical predictive functions and circadian controls show a fine-tune control that minimizes water loss while potentially increasing posterior carbon uptake.
Analytic descriptions of cylindrical electromagnetic waves in a nonlinear medium
Authors: Xiong Hao , Si Liu-Gang , Yang Xiaoxue , Wu Ying
Published: June 2015

A simple but highly efficient approach for dealing with the problem of cylindrical electromagnetic waves propagation in a nonlinear medium is proposed based on an exact solution proposed recently. We derive an analytical explicit formula, which exhibiting rich interesting nonlinear effects, to describe the propagation of any amount of cylindrical electromagnetic waves in a nonlinear medium. The results obtained by using the present method are accurately concordant with the results of using traditional coupled-wave equations. As an example of application, we discuss how a third wave affects the sum- and difference-frequency generation of two waves propagation in the nonlinear medium.
Alteration of mRNA and microRNA expression profiles in rat muscular type vasculature in early postnatal development
Authors: Gaynullina Dina , Dweep Harsh , Gloe Torsten , Tarasova Olga S. , Sticht Carsten , Gretz Norbert , Schubert Rudolf
Published: June 2015

The vascular system is characterized by a high degree of plasticity. In particular, functional and structural remodeling of the arterial system takes place during early postnatal development. However, the mechanisms providing such alterations in the rapidly growing organisms are poorly understood, especially for the peripheral vasculature. To explore this, we performed mRNA- and miRNA microarray analysis on muscular type saphenous arteries of young (10–12 days) and adult (2–3 months) rats. Thirty-eight significant pathways (such as oxidative phosphorylation, MAPK signaling, metabolism, cell cycle, DNA replication and focal adhesion) were obtained on differentially regulated genes during postnatal development. Many differentially regulated genes were determined as target- and miRNA-hubs. We also found 92 miRNAs differentially expressed in arteries of young and adult rats. Several significantly regulated pathways were found on these regulated miRNAs. Interestingly, these biological cascades also contain those significantly enriched pathways that were previously identified based on the differently expressed genes. Our data indicate that the expression of many genes involved in the regulation of pathways that are relevant for different functions in arteries may be under the control of miRNAs and these miRNAs regulate the functional and structural remodeling occurring in the vascular system during early postnatal development.
Bursts in discontinuous Aeolian saltation
Authors: Carneiro M. V. , Rasmussen K. R. , Herrmann H. J.
Published: June 2015

Close to the onset of Aeolian particle transport through saltation we find in wind tunnel experiments a regime of discontinuous flux characterized by bursts of activity. Scaling laws are observed in the time delay between each burst and in the measurements of the wind fluctuations at the fluid threshold Shields number θc. The time delay between each burst decreases on average with the increase of the Shields number until sand flux becomes continuous. A numerical model for saltation including the wind-entrainment from the turbulent fluctuations can reproduce these observations and gives insight about their origin. We present here also for the first time measurements showing that with feeding it becomes possible to sustain discontinuous flux even below the fluid threshold.
Disturbance of cardiac gene expression and cardiomyocyte structure predisposes Mecp2-null mice to arrhythmias
Authors: Hara Munetsugu , Takahashi Tomoyuki , Mitsumasu Chiaki , Igata Sachiyo , Takano Makoto , Minami Tomoko , Yasukawa Hideo , Okayama Satoko , Nakamura Keiichiro , Okabe Yasunori , Tanaka Eiichiro , Takemura Genzou , Kosai Ken-ichiro , Yamashita Yushiro , Matsuishi Toyojiro
Published: June 2015

Methyl-CpG-binding protein 2 (MeCP2) is an epigenetic regulator of gene expression that is essential for normal brain development. Mutations in MeCP2 lead to disrupted neuronal function and can cause Rett syndrome (RTT), a neurodevelopmental disorder. Previous studies reported cardiac dysfunction, including arrhythmias in both RTT patients and animal models of RTT. In addition, recent studies indicate that MeCP2 may be involved in cardiac development and dysfunction, but its role in the developing and adult heart remains unknown. In this study, we found that Mecp2-null ESCs could differentiate into cardiomyocytes, but the development and further differentiation of cardiovascular progenitors were significantly affected in MeCP2 deficiency. In addition, we revealed that loss of MeCP2 led to dysregulation of endogenous cardiac genes and myocardial structural alterations, although Mecp2-null mice did not exhibit obvious cardiac functional abnormalities. Furthermore, we detected methylation of the CpG islands in the Tbx5 locus and showed that MeCP2 could target these sequences. Taken together, these results suggest that MeCP2 is an important regulator of the gene-expression program responsible for maintaining normal cardiac development and cardiomyocyte structure.
Snoozing through the storm: torpor use during a natural disaster
Authors: Nowack Julia , Rojas A. Daniella , Körtner Gerhard , Geiser Fritz
Published: June 2015

Although storms provide an extreme environmental challenge to organisms and are predicted to increase in frequency and intensity due to climate change, there are no quantitative observations on the behaviour and physiology of animals during natural disasters. We provide the first data on activity and thermal biology of a free-ranging, arboreal mammal during a storm with heavy rain and category 1 cyclone wind speeds. We studied a population of sugar gliders (Petaurus breviceps), a species vulnerable to bad weather due to their small body size and mode of locomotion, in a subtropical habitat during spring when storms are common. Although torpor is generally rare in this species, sugar gliders remained inactive or reduced foraging times during the storm and further minimized energy demands by entering deep torpor. All animals survived the storm and reverted to normal foraging activity during the following night(s). It thus appears that heterothermic mammals have a crucial adaptive advantage over homeothermic species as they can outlast challenging weather events, such as storms and floods, by reducing metabolism and thus energetic needs.
Self-association of Trimethylguanosine Synthase Tgs1 is required for efficient snRNA/snoRNA trimethylation and pre-rRNA processing
Authors: Boon Kum-Loong , Pearson Michael David , Koš Martin
Published: June 2015

Trimethylguanosine Synthase catalyses transfer of two methyl groups to the m7G cap of RNA polymerase II transcribed snRNAs, snoRNAs and telomerase RNA TLC1 to form a 2,2,7-trimethylguanosine cap. While in vitro studies indicate that Tgs1 functions as a monomer and the dimethylation of m7G caps is not a processive reaction, partially methylated sn(o)RNAs are typically not detected in living cells. Here we show that both yeast and human Tgs1p possess a conserved self-association property located at the N-terminus. A disruption of Tgs1 self-association led to a strong reduction of sn(o)RNA trimethylation as well as reduced nucleolar enrichment of Tgs1. Self-association of Tgs1p and its catalytic activity were also prerequisite to bypass the requirement for its accessory factor Swm2p for efficient pre-rRNA processing and snRNA trimethylation. The ability to self-associate might enable Tgs1 to efficiently dimethylate the caps of the targeted RNAs in vivo.
The effect of BIM deletion polymorphism on intrinsic resistance and clinical outcome of cancer patient with kinase inhibitor therapy
Authors: Ying Hou-Qun , Chen Jie , He Bang-Shun , Pan Yu-Qin , Wang Feng , Deng Qi-Wen , Sun Hui-Ling , Liu Xian , Wang Shu-Kui
Published: June 2015

A common deletion polymorphism within B-cell chronic lymphocytic leukemia-lymphoma like 11 gene (BIM) was deemed to be a genetic cause leading to compromised kinase inhibitor therapeutic efficacy in cancer individuals. However, the results reported were not consistent. Thus, a comprehensive meta-analysis containing 12 eligible studies including 1,532 Asian patients was conducted to investigate a steady and reliable conclusion. The results showed that BIM deletion polymorphism was significantly associated with tyrosine kinase inhibitor (TKI) clinical efficacy in term of response rate (Ph = 0.349, HR = 0.438, 95%CI = 0.274–0.699) and disease control rate (Ph = 0.941, HR = 0.370, 95%CI = 0.202–0.678) in EGFR-mutated NSCLC population, not in CML and HCC subgroups. Additionally, EGFR-mutated NSCLC patient harbored BIM deletion polymorphism was associated with a shorter progression-free survival (PFS) than those with BIM wild polymorphism (Ph = 0.580, adjusted HR = 2.194, 95%CI = 1.710–2.814). However, no significant association was examined between BIM deletion polymorphism and overall survival (OS) and toxic adverse events in EGFR-mutated NSCLC population and it was not associated with PFS and OS in HCC subgroup. These findings revealed that BIM deletion polymorphism might be a genetic cause of intrinsic resistance to TKI therapy and it could be emerged as an independent predictor to identify patients who would benefit from TKI targeted therapy in EGFR-mutated NSCLC.
Association between Int7G24A rs334354 polymorphism and cancer risk: a meta-analysis of case-control studies
Authors: Wu Weixiang , Tong Yeqing , Wei Xiaoyun , Zhao Qiang , Pan Xiaoqi , Yu Guangxia , Lu Qing
Published: June 2015

Accumulating evidences have suggested the potential association between Int7G24A (rs334354) polymorphism and cancer risk. However, results from epidemiological studies are controversial. We thus conducted this meta-analysis to clarify the association. Relevant studies were identified on electronic databases according to the inclusion criteria. A total of 13 case-control studies containing 4092 cases and 5909 controls were included in our meta-analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) were applied to assess the association. The results of the overall population had suggested that Int7G24A polymorphism had an increased risk for cancer, reaching significant levels in the 2 genetic models (allele model, OR = 1.25, 95% CI 1.09-1.42,P = 0.001; dominant model, OR = 1.24, 95% CI 1.06-1.46,P < 0.008). Besides, significant association was found among Asian population (allele model, OR = 1.27, 95% CI 1.11-1.45,P < 0.001; dominant model, OR = 1.28, 95% CI 1.11-1.49,P < 0.001), whereas there was non-significant relationship detected among Caucasian population (allele model, OR = 1.08, 95% CI 0.92-1.26,P = 0.352; dominant model, OR = 1.05, 95% CI 0.87-1.26,P = 0.639). The present meta-analysis had suggested that Int7G24A polymorphism of gene TGFBR1 involved in the transforming growth factor beta (TGF-β) signaling pathway had a significantly increased risk for cancer development.
Integrated travel network model for studying epidemics: Interplay between journeys and epidemic
Authors: Ruan Zhongyuan , Wang Chaoqing , Ming Hui Pak , Liu Zonghua
Published: June 2015

The ease of travelling between cities has contributed much to globalization. Yet, it poses a threat on epidemic outbreaks. It is of great importance for network science and health control to understand the impact of frequent journeys on epidemics. We stress that a new framework of modelling that takes a traveller’s viewpoint is needed. Such integrated travel network (ITN) model should incorporate the diversity among links as dictated by the distances between cities and different speeds of different modes of transportation, diversity among nodes as dictated by the population and the ease of travelling due to infrastructures and economic development of a city and round-trip journeys to targeted destinations via the paths of shortest travel times typical of human journeys. An example is constructed for 116 cities in China with populations over one million that are connected by high-speed train services and highways. Epidemic spread on the constructed network is studied. It is revealed both numerically and theoretically that the traveling speed and frequency are important factors of epidemic spreading. Depending on the infection rate, increasing the traveling speed would result in either an enhanced or suppressed epidemic, while increasing the traveling frequency enhances the epidemic spreading.
Pedican: an online gene resource for pediatric cancers with literature evidence
Authors: Zhao Min , Ma Lei , Liu Yining , Qu Hong
Published: June 2015

Pediatric cancer (PC), that is cancer occurring in children, is the leading cause of death among children worldwide, with an incidence of 175,000 per year. Elucidating the genetic abnormalities and underlying cellular mechanisms may provide less toxic curative treatments. Therefore, it is important to understand the pathology of pediatric cancer at the genetic, genomic and epigenetic level. To unveil the cellular complexity of PC, we have developed a database of pediatric cancers (Pedican), the first literature-based pediatric gene data resource by comprehensive literature curation and data integration. In the current release, Pedican contains 735 human genes, 88 gene fusion and 24 chromosome abnormal events curated from 2245 PubMed abstracts. Pedican provides detailed annotations for each gene, such as Entrez gene information, involved pathways, protein–protein interactions, mutations, gene expression, methylation sites, TF regulation and post-translational modification. Additionally Pedican has a user-friendly web interface, which allows sophisticated text query, sequence searches and browsing by highlighted literature evidence and hundreds of cancer types. Overall, our curated pediatric cancer-related gene list maps the genomic and cellular landscape for various pediatric cancers, providing a valuable resource for further experiment design. The Pedican is available at http://pedican.bioinfo-minzhao.org/.
Network nanostructured polypyrrole hydrogel/Au composites as enhanced electrochemical biosensing platform
Authors: Rong Qinfeng , Han Hongliang , Feng Feng , Ma Zhanfang
Published: June 2015

In this work, a new network nanocomposite composed of polypyrrole hydrogel (PPy hydrogel) loaded gold nanoparticles (AuNPs) was prepared. The PPy hydrogel was directly synthesized by mixing the pyrrole monomer and phytic acid and the mixed solution can be gelated to form hydrogel at once. The three-dimensional network nanostructured PPy hydrogel not only provided a greater effective surface area for increasing the quantity of immobilized biomolecules and facilitated the transport of electrons and ions, but also exhibited an improved conductivity. Meanwhile, the electrodeposited AuNPs on the PPy hydrogel can further increase the specific surface area to capture a large amount of antibodies as well as improve the capability of electron transfer. The network PPy hydrogel/Au nanocomposites were successfully employed for the fabrication of a sensitive label-free amperometric immunosensor. Carcinoembryonic antigen (CEA) was used as a model protein. The proposed immunosensor exhibited a wide linear detection range from 1 fg mL−1 to 200 ng mL−1 and an ultralow limit of detection of 0.16 fg mL−1 (S/N = 3) and it also possessed good selectivity. Moreover, the detection of CEA in ten human serums showed satisfactory accuracy compared with the data determined by ELISA, indicating that the immunosensor provided potential application for clinical diagnosis.
CancerHSP: anticancer herbs database of systems pharmacology
Authors: Tao Weiyang , Li Bohui , Gao Shuo , Bai Yaofei , Shar Piar Ali , Zhang Wenjuan , Guo Zihu , Sun Ke , Fu Yingxue , Huang Chao , Zheng Chunli , Mu Jiexin , Pei Tianli , Wang Yuan , Li Yan , Wang Yonghua
Published: June 2015

The numerous natural products and their bioactivity potentially afford an extraordinary resource for new drug discovery and have been employed in cancer treatment. However, the underlying pharmacological mechanisms of most natural anticancer compounds remain elusive, which has become one of the major obstacles in developing novel effective anticancer agents. Here, to address these unmet needs, we developed an anticancer herbs database of systems pharmacology (CancerHSP), which records anticancer herbs related information through manual curation. Currently, CancerHSP contains 2439 anticancer herbal medicines with 3575 anticancer ingredients. For each ingredient, the molecular structure and nine key ADME parameters are provided. Moreover, we also provide the anticancer activities of these compounds based on 492 different cancer cell lines. Further, the protein targets of the compounds are predicted by state-of-art methods or collected from literatures. CancerHSP will help reveal the molecular mechanisms of natural anticancer products and accelerate anticancer drug development, especially facilitate future investigations on drug repositioning and drug discovery. CancerHSP is freely available on the web at http://lsp.nwsuaf.edu.cn/CancerHSP.php.
Rice protein hydrolysates stimulate GLP-1 secretion, reduce GLP-1 degradation, and lower the glycemic response in rats
Authors: Ishikawa Yuki , Hira Tohru , Inoue Daisuke , Harada Yukikazu , Hashimoto Hiroyuki , Fujii Mikio , Kadowaki Motoni , Hara Hiroshi
Published: June 2015

Single oral administration of rice protein hydolysates stimulated GLP-1 secretion and reduced glycemic response in awake rats. Luminal REPH and RBPH reduced DPP-IV activity in the mesenteric vein.
Incorporation of a FRET dye pair into mesoporous materials: a comparison of fluorescence spectra, FRET activity and dye accessibility
Authors: Widmer Susanne , Reber Michael J. , Müller Patrick , Housecroft Catherine E. , Constable Edwin C. , Rossi René M. , Brühwiler Dominik , Scherer Lukas J. , Boesel Luciano F.
Published: June 2015

The incorporation of fluorescent dyes into mesoporous silicates was investigated as potential FRET based systems for gas sensing applications with better response than non-particulate systems.
Fast protein detection in raw blood by size-exclusion SPR sensing
Authors: Terao Kyohei , Hiramatsu Shin-ichi , Suzuki Takaaki , Takao Hidekuni , Shimokawa Fusao , Oohira Fumikazu
Published: June 2015

We have developed a simple technique for detecting protein in raw blood samples using size-exclusion surface plasmon resonance (SPR) sensing.
Multi-walled carbon nanotube and nanosilica chemically modified carbon paste electrodes for the determination of mercury(ii) in polluted water samples
Authors: Ali Tamer Awad , Mohamed Gehad G.
Published: June 2015

Novel carbon paste ion selective electrodes based on the 1,4-bis(6-bromohexyloxy)benzene (BHOB) ionophore were constructed in order to determine the Hg(ii) ion concentration.
Development of sandwich ELISA and immunochromatographic strip methods for the detection of Xanthomonas oryzae pv. oryzae
Authors: Wu Xiaoling , Kong Dezhao , Song Shanshan , Liu Liqiang , Kuang Hua , Xu Chuanlai
Published: June 2015

A pair of sensitive monoclonal antibodies against both Xanthomonas oryzae pv. oryzae and Xanthomonas oryzae pv. oryzicola were generated by immunizing mice and cell fusion techniques.
Digital videometrics analysis for the kinetic determination of dopamine in the presence of ascorbic acid based on the formation of silver nanoparticles
Authors: Hemmateenejad Bahram , Shakerizadeh-Shirazi Fatemeh , Heidari Sahar , Shahrivar-kevishahi Arezoo
Published: June 2015

A simple, cost-effective and rapid method for the visual detection of dopamine (DA) and ascorbic acid (AsA) based on the video-image analysis has been developed.
Heterostructure of AuAg nanoparticles tipping on Ag2S quantum tubes
Authors: Tian Yang , Zhou Weiwei , Tang Hanqin , Fu Hongbing , Wang Ligang
Published: June 2015

A novel heteronanostructure of AuAg nanoparticles tipping on Ag2S quantum tubes is reported for the first time.
Effect of microtubule polymerization on photoinduced hydrogen generation
Authors: Okeyoshi Kosuke , Kawamura Ryuzo , Yoshida Ryo , Osada Yoshihito
Published: June 2015

Here we report a novel reaction field for photoinduced H2 generation by utilizing microtubules as a medium with hierarchical structure.
Fragmentation mechanism of the generation of colloidal copper(i) iodide nanoparticles by pulsed laser irradiation in liquids
Authors: Schaumberg Christian Alexander , Wollgarten Markus , Rademann Klaus
Published: June 2015

Pulsed laser irradiation of copper(i) iodide in liquids is the text book example for a fragmentation mechanism. This is in stark contrast to the reductive ablation mechanism.
Visible light absorption and photoelectrochemical activity of colorless molecular 1,3-bis(dicyanomethylidene)indane (BDMI) by surface complexation on TiO2
Authors: Ko Soo-Byung , Ryu Tae In , Cho An-Na , Fujisawa Junichi , Segawa Hiroshi , Park Nam-Gyu
Published: June 2015

Adsorption of colorless 1,3-bis(dicyanomethylidene)indane (BDMI) onto a nanocrystalline TiO2 surface unusually turned the BDMI a deep blue color.
Exciton intrachain transport induced by interchain packing configurations in conjugated polymers
Authors: Meng Ruixuan , Gao Kun , Zhang Gaiyan , Han Shixuan , Yang Fujiang , Li Yuan , Xie Shijie
Published: June 2015

Exciton intrachain transport in polymers induced by the driving force resulting from the gradient of exciton creation energy along chains.
Influence of the molecular-oriented structure of ionic liquids on the crystallinity of aluminum hydroxide prepared by a sol–gel process in ionic liquids
Authors: Kinoshita K. , Yanagimoto H. , Suzuki T. , Minami H.
Published: June 2015

The influence of the structure of ionic liquids on the crystallinity of aluminum hydroxide (Al(OH)3) prepared by a sol–gel process with aluminum isopropoxide (Al(OPri)3) in imidazolium-based ionic liquids was investigated.
Development and applications of the LFDFT: the non-empirical account of ligand field and the simulation of the f–d transitions by density functional theory
Authors: Ramanantoanina Harry , Sahnoun Mohammed , Barbiero Andrea , Ferbinteanu Marilena , Cimpoesu Fanica
Published: June 2015

Spectral profiles for f → d transitions in CaF2:Eu2+and SrCl2:Eu2+were simulated using LFDFT.
Slow dynamics of water confined in Newton black films
Authors: Chen Meng , Lu Xiancai , Liu Xiandong , Hou Qingfeng , Zhu Youyi , Zhou Huiqun
Published: June 2015

Macroscopic polarization effect and retardation of ions and ionic groups concertedly lead to slowdown of water dynamics in Newton black films.
Synthesis and reactivity of TADDOL-based chiral Fe(ii) PNP pincer complexes-solution equilibria between κ2P,N- and κ3P,N,P-bound PNP pincer ligands
Authors: Holzhacker Christian , Stöger Berthold , Carvalho Maria Deus , Ferreira Liliana P. , Pittenauer Ernst , Allmaier Günter , Veiros Luis F. , Realista Sara , Gil Adrià , Calhorda Maria José , Müller Danny , Kirchner Karl
Published: June 2015

Fe(ii) complexes bearing chiral PNP pincer ligands based on R,R-TADDOL are described.
Formation of the spirocyclic, Si-centered cage cations [ClP(NSiMe3)2Si(NSiMe3)2P5]+ and [P5(NSiMe3)2Si(NSiMe3)2P5]2+
Authors: Holthausen M. H. , Weigand J. J.
Published: June 2015

A GaCl3-mediated rearrangement of a bicyclic phosphorus–nitrogen–silicon heterocycle gives phosphenium ion intermediates which are suitable for the activation of P4.
An anion induced multisignaling probe for Hg2+and its application for fish kidney and liver tissue imaging studies
Authors: Mandal Sandip , Banerjee Arnab , Ghosh Debasree , Mandal Dipak Kumar , Safin Damir A. , Babashkina Maria G. , Robeyns Koen , Mitoraj Mariusz P. , Kubisiak Piotr , Garcia Yann , Das Debasis
Published: June 2015

A highly efficient binder for the selective recognition and determination of Hg(NO3)2concentration in kidney and liver tissues of fish using a fluorescence method is described.
Dimer formation upon deprotonation: synthesis and structure of a m-terphenyl substituted (R,S)-dilithium disiloxanolate disilanol
Authors: Čas Daniel , Hurkes Natascha , Spirk Stefan , Belaj Ferdinand , Bruhn Clemens , Rechberger Gerald N. , Pietschnig Rudolf
Published: June 2015

The primary products in deprotonating m-terphenylsilanetriol were detected in traces besides disiloxanes as major products, which were characterized as donor adducts.
Seasonal variations in the regiodistribution of oil extracted from small-spotted catshark and bogue
Authors: Morales-Medina R. , García-Moreno P. J. , Pérez-Gálvez R. , Muñío M. , Guadix A. , Guadix E. M.
Published: June 2015

Extracted oil presents a high content of PUFA (<50%) at the sn-2 position.
Identification of new hit scaffolds by INPHARMA-guided virtual screening
Authors: Sikorska Justyna , Codutti Luca , Skjærven Lars , Elshorst Bettina , Saez-Ameneiro Rebeca , Angelini Andrea , Monecke Peter , Carlomagno Teresa
Published: June 2015

INPHARMA, an NMR-based method that determines ligand binding poses, allows finding novel scaffolds as inhibitors of a target protein.
Nickel-responsive transcriptional regulators
Authors: Musiani Francesco , Zambelli Barbara , Bazzani Micaela , Mazzei Luca , Ciurli Stefano
Published: June 2015

The structural features, metal coordination modes and metal binding thermodynamics of known Ni(ii)-dependent transcriptional regulators are highlighted and discussed.
Influence of reducing agents on the cytotoxic activity of platinum(iv) complexes: induction of G2/M arrest, apoptosis and oxidative stress in A2780 and cisplatin resistant A2780cis cell lines
Authors: Pichler Verena , Göschl Simone , Schreiber-Brynzak Ekaterina , Jakupec Michael A , Galanski Mathea S , Keppler Bernhard K
Published: June 2015

The concept of PtIV prodrug design is one advanced strategy to increase the selectivity for cancer cells and to reduce systemic toxicity in comparison to established platinum-based chemotherapy. PtIV complexes are thought to be activated by reduction via physiological reductants, such as ascorbic acid or glutathione. Nevertheless, only few investigations on the link between the reduction rate, which is influenced by the reductant, and the ligand sphere of the PtIV metal centre have been performed so far. Herein, we investigated a set of PtIV compounds with varying rates of reduction with respect to their cytotoxicity and drug accumulation in A2780 and A2780cis ovarian cancer cell lines, their influence on the cell cycle, efficiency of triggering apoptosis, and ability to interfere with plasmid DNA (pUC19). The effects caused by PtIV compounds were compared without or with extracellularly added ascorbic acid and glutathione (or its precursor N-acetylcysteine) to gain understanding of the impact of increased levels of the reductant on the activity of such complexes. Our results demonstrate that reduction is required prior to plasmid interaction. Furthermore, the rate of reduction is crucial for the efficiency of this set of PtIV compounds. The substances that are reduced least likely showed similar performances, whereas the fastest reducing substance was negatively affected by an increased extracellular level of reducing agents, with reduced cytotoxicity and lower efficiency in inducing apoptosis and G2/M arrest. These results confirm the connection between reduction and activity, and prove the strong impact of the reduction site on the activity of PtIV complexes.
Y2O3:Yb,Er@mSiO2–CuxS double-shelled hollow spheres for enhanced chemo-/photothermal anti-cancer therapy and dual-modal imaging
Authors: Yang Dan , Yang Guixin , Wang Xingmei , Lv Ruichan , Gai Shili , He Fei , Gulzar Arif , Yang Piaoping
Published: June 2015

Y2O3:Yb,Er@mSiO2double-shelled hollow spheres (DSHSs) exhibit high anti-cancer efficacy due to enabling synergistic therapy and their excellentin vitroandin vivoCT and up-conversion fluorescence imaging properties.
Design, fabrication and charge recombination analysis of an interdigitated heterojunction nanomorphology in P3HT/PC70BM solar cells
Authors: Balderrama Victor S. , Albero Josep , Granero Pedro , Ferré-Borrull Josep , Pallarés Josep , Palomares Emilio , Marsal Lluis F.
Published: June 2015

Fabrication and study of the charge extraction and charge recombination mechanisms for an interdigitated heterojunction nanomorphology in P3HT/PC70BM solar cells.
Reversible control of pore size and surface chemistry of mesoporous silica through dynamic covalent chemistry: philicity mediated catalysis
Authors: Singh Dheeraj Kumar , Pavan Kumar B. V. V. S. , Eswaramoorthy M.
Published: June 2015

On–Off catalysts: pH induced reversible switching of pore size and philicity in mesoporous silica through dynamic imine modules was used to gate the access of catalytically active gold nanoparticles inside the pores.
Upconversion luminescence behavior of single nanoparticles
Authors: Zhou Jiajia , Xu Shiqing , Zhang Junjie , Qiu Jianrong
Published: June 2015

The angle of this review is novel because it surveys the characterization methods, photophysical phenomena, and applications of single upconversion nanoparticles.
Combination of carbon dot and polymer dot phosphors for white light-emitting diodes
Authors: Sun Chun , Zhang Yu , Sun Kai , Reckmeier Claas , Zhang Tieqiang , Zhang XiaoYu , Zhao Jun , Wu Changfeng , Yu William W. , Rogach Andrey L.
Published: June 2015

The white light-emitting diodes with high color rendering index (85–96) and widely variable color temperatures(2805–7786 K) were fabricated from carbon-based nanomaterials with weak reabsorption and no energy transfer crosstalk and showed excellent color stability.
Dynamically configurable hybridization of plasmon modes in nanoring dimer arrays
Authors: Zhang Lei , Dong Zhaogang , Wang Ying Min , Liu Yan Jun , Zhang Shuang , Yang Joel Kwang Wei , Qiu Cheng-Wei
Published: June 2015

We present a novel strategy capable of dynamically configuring the plasmon-induced transparency effect with a polarization-dependent controllability based on a nanoring dimer array.
A practical and highly sensitive C3N4-TYR fluorescent probe for convenient detection of dopamine
Authors: Li Hao , Yang Manman , Liu Juan , Zhang Yalin , Yang Yanmei , Huang Hui , Liu Yang , Kang Zhenhui
Published: June 2015

The C3N4-tyrosinase (TYR) hybrid is a highly accurate, sensitive and simple fluorescent probe for the detection of dopamine (DOPA).
Galantamine-loaded PLGA nanoparticles, from nano-emulsion templating, as novel advanced drug delivery systems to treat neurodegenerative diseases
Authors: Fornaguera C. , Feiner-Gracia N. , Calderó G. , García-Celma M. J. , Solans C.
Published: June 2015

Schematic representation of the methodology used in this study to prepare GAL-loaded PLGA nanoparticles from nano-emulsion templating: nano-emulsification using the PIC low-energy method followed by solvent evaporation.
Highly stereoselective construction of novel dispirooxindole–imidazolidines via self-1,3-dipolar cyclization of ketimines
Authors: Sun Yan-Hua , Xiong Yu , Peng Chu-Qin , Li Wu , Xiao Jun-An , Yang Hua
Published: June 2015

Self-1,3-dipolar [3 + 2]-cycloaddition of ketimines was successfully realized for the first time and the unprecedented dispirooxindole–imidazolidines were synthesized.
Multiple hydrogen bonding mediates the formation of multicompartment micelles and hierarchical self-assembled structures from pseudo A-block-(B-graft-C) terpolymers
Authors: Wu Yi-Chen , Prasad Bastakoti Bishnu , Pramanik Malay , Yamauchi Yusuke , Kuo Shiao-Wei
Published: June 2015

Different multi-compartment micelle structures: raspberry-like spheres, core–shell–corona cylinders, nanostructured vesicles, onion-like structures, and woodlouse-like structures was found dependent upon selective solvent concentration.
Linear and three-arm star hydroxytelechelic poly(benzyl β-malolactonate)s: a straightforward one-step synthesis through ring-opening polymerization
Authors: Barouti Ghislaine , Jaffredo Cédric G. , Guillaume Sophie M.
Published: June 2015

Ring-opening polymerization (ROP) of racemic-benzyl β-malolactonate (MLABe) initiated by an alcohol (diol or triol) and catalyzed by a metal triflate M(OTf)3, afforded α,ω-hydroxy telechelic PMLABe under mild operating conditions.
Cationic benzylidene cyclopentanone photosensitizers for selective photodynamic inactivation of bacteria over mammalian cells
Authors: Fang Yanyan , Liu Tianlong , Zou Qianli , Zhao Yuxia , Wu Feipeng
Published: June 2015

Cationic modified benzylidene cyclopentanone photosensitizers selectively photo-inactivate bacterial cells over mammalian cells.
Synthesis of manganese dioxide/iron oxide/graphene oxide magnetic nanocomposites for hexavalent chromium removal
Authors: Liu Yan , Luo Chao , Cui Guijia , Yan Shiqiang
Published: June 2015

Effective removal of heavy metal ions from wastewater is one of the important environment issues.
Effect of hematite addition to CaSO4 oxygen carrier in chemical looping combustion of coal char
Authors: Ding Ning , Zhang Chengwu , Luo Cong , Zheng Ying , Liu Zhigang
Published: June 2015

Catalytic mechanism of synergy effect of iron oxide in gasification of char and in the reduction of CaSO4 oxygen carrier.
Lead biotransformation potential of allochthonous Bacillus sp. SKK11 with sesame oil cake extract in mine soil
Authors: Govarthanan Muthusamy , Park Sung-Hee , Park Yool-Jin , Myung Hyun , Krishnamurthy R. R. , Lee Sang-Hyun , Lovanh Nanh , Kamala-Kannan Seralathan , Oh Byung-Taek
Published: June 2015

Growth kinetics of isolate at various Pb concentration and in the presence of sesame oil cake extract.
Monodisperse magnetic ion imprinted polymeric microparticles prepared by RAFT polymerization based on γ-Fe2O3@meso-SiO2nanospheres for selective solid-phase extraction of Cu(ii) in water samples
Authors: Liu Zhanchao , Hu Zhaoyong , Liu Yan , Meng Minjia , Ni Liang , Meng Xiangguo , Zhong Guoxing , Liu Fangfang , Gao Yanmin
Published: June 2015

Utilising a general protocol for making surface-imprinted core–shell microparticlesviaa RAFT-mediated approach, we developed a Cu(ii) imprinted polymer with a novel magnetic nanosphere, γ-Fe2O3@meso-SiO2, as support.
Enhanced H2 dissociative phenomena of Pt–Ir electrocatalysts for PEMFCs: an integrated experimental and theoretical study
Authors: Kwon Soonchul , Ham Dong Jin , Lee Seung Geol
Published: June 2015

Bimetallic Pt–Ir electrocatalysts enhance the H2 dissociation for PEMFCs.
Comparative investigation of spectroelectrochemical and biosensor application of two isomeric thienylpyrrole derivatives
Authors: Ayranci Rukiye , Soganci Tugba , Guzel Merve , Demirkol Dilek Odaci , Ak Metin , Timur Suna
Published: June 2015

In the present work, we performed a comparative investigation of spectroelectrochemical and biosensor application of two isomeric thienylpyrrole derivatives.
Single-crystal heterostructured PbTiO3/CdS nanorods with enhanced visible-light-driven photocatalytic performance
Authors: Jiang Shan , Ren Zhaohui , Li Ming , Gong Siyu , Yu Yifeng , Pei Jingyuan , Wei Xiao , Shen Ge , Han Gaorong
Published: June 2015

Single-crystal heterostructured PbTiO3/CdS nanorods as efficient visible-light-driven photocatalysts for the degradation of methylene blue (MB).
Preparation and properties of composite separators with asymmetric structures for alkaline batteries
Authors: Xiao Wei , Zhao Lina , Gong Yaqun , Wang Hong , Liu Jianguo , Yan Chuanwei
Published: June 2015

The separator is formed from a microporous layer and a macroporous layer by a point-bonded method. It possesses excellent wettability and high stability in a strong alkaline electrolyte, resulting in a good candidate for alkaline batteries.
The role of Br in the selective synthesis of thin-walled carbon-nanotubes with micrometre-length Fe3C-filling, Fe3C tip-filled carbon nanotubes or empty carbon nanotubes by pyrolysis of ferrocene and (6-bromohexyl)ferrocene mixtures
Authors: Guo J. , He Y. , Mu Lan , Wang S. , Weng Zhichao , Xiang G. , Boi Filippo S.
Published: June 2015

We report an advanced chemical vapour deposition method which allows the synthesis-selection of thin walled carbon nanotubes filled with Fe3C, Fe3C tip-filled nanotubes or of empty nanotubes by addition of (6-bromohexyl)ferrocene to ferrocene.
Graphene nanosheets decorated with ZnO nanoparticles: facile synthesis and promising application for enhancing the mechanical and gas barrier properties of rubber nanocomposites
Authors: Lin Yong , Zeng Zhikai , Zhu Jiarong , Chen Song , Yuan Xue , Liu Lan
Published: June 2015

In this study, graphene nanosheets decorated with ZnO nanoparticles (NZG) were prepared from graphene oxide by a facile solvothermal method.
Molecularly imprinted fluorescent chemosensor synthesized using quinoline-modified-β-cyclodextrin as monomer for spermidine recognition
Authors: Cheng Yang , Jiang Ping , Dong Xiangchao
Published: June 2015

Preparation of imprinted fluorescent chemosensor using quinoline-modified-β-cyclodextrin as monomer for spermidine recognition.
Fibrous membranes electrospun from the suspension polymerization product of styrene and butyl acrylate for oil–water separation
Authors: Ning L. Q. , Xu N. K. , Wang R. , Liu Y.
Published: June 2015

Fibrous membranes electrospun from the copolymer of styrene and butyl acrylate could separate oil from water due to their excellent hydrophobicity.
Low-temperature catalytic decarboxylation of formic and acetic acid over a Ru/TiO2 catalyst: prospects for continuous production of energy-rich gaseous mixtures
Authors: Osojnik Črnivec I. G. , Djinović P. , Erjavec B. , Pintar A.
Published: June 2015

Long-term continuous reactor operation demonstrates energy-efficient CH3COOH conversion pathway and provides appropriate strategies for avoiding unwanted side-reactions with HCOOH feed.
Novel CuO/chitosan nanocomposite thin film: facile hand-picking recoverable, efficient and reusable heterogeneous photocatalyst
Authors: Senthil Kumar P. , Selvakumar M. , Babu Sundaram Ganesh , Jaganathan Saravana Kumar , Karuthapandian S. , Chattopadhyay Santanu
Published: June 2015

The present work demonstrates a new simple hand-picking technique for the 100% recovery of a CuO nanosphere photocatalyst.
Construction of an all-substituted pyrrolidine derivative with multiple stereogenic centers and Betti-base-derived γ-amino alcohols by [1,2]-Wittig rearrangement
Authors: Wang Cai-Yun , Dong Cheng , Zheng Zhan-Jiang , Xu Zheng , Yang Ke-Fang , Xu Li-Wen
Published: June 2015

The construction of Betti base-derived γ-amino alcohols and all-substituted pyrrolidine derivative with multiple stereogenic centers has been developed successfully through neighboring lithium-assisted [1,2]-Wittig rearrangement (NLAWR).
Palladium-catalyzed ligand-free and efficient Suzuki–Miyaura reaction of heteroaryl halides with MIDA boronates in water
Authors: Liu Chun , Li Xinmin , Liu Chao , Wang Xinnan , Qiu Jieshan
Published: June 2015

A simple and environment-friendly protocol for the palladium-catalyzed Suzuki–Miyaura reaction of heteroaryl halides with N-methyliminodiacetic acid (MIDA) boronates in pure water is developed.
An efficient mechanochemical synthesis of amides and dipeptides using 2,4,6-trichloro-1,3,5-triazine and PPh3
Authors: Duangkamol Chuthamat , Jaita Subin , Wangngae Sirilak , Phakhodee Wong , Pattarawarapan Mookda
Published: June 2015

A mechanochemical method for amidation of carboxylic acids and urethane-protected (Fmoc, Cbz, Boc) α-amino acids has been developed as a facile, efficient, and eco-friendly route toward amides and dipeptides.
An effective quaternary nano-sized Er3+:Y3Al5O12/Pt–PdS/ZnS visible-light photocatalyst for H2 production
Authors: Lu Chunxiao , Chen Yang , Li Yun , Ma Chunhong , Zhang Hongbo , Guo Yuwei , Wang Jun
Published: June 2015

The visible-light photocatalytic H2 production activity of Er3+:Y3Al5O12/Pt–PdS/ZnS was evaluated by using Na2S and Na2SO3 as sacrificial reagents. Er3+:Y3Al5O12, Pt and PdS can effectively improve the visible-light photocatalytic activity of ZnS.
Beyond a solvent: the roles of 1-butyl-3-methylimidazolium chloride in the acid-catalysis for cellulose depolymerisation
Authors: de Oliveira Heitor Fernando Nunes , Farès Christophe , Rinaldi Roberto
Published: June 2015

1-Butyl-3-methylimidazolium chloride plays other roles in the acid-catalysed depolymerisation of cellulose rather than being ‘merely’ a solvent for the biopolymer. The ionic liquid species enhances the Hammett acidity of the catalyst, thus improving the kinetics of cellulose depolymerisation.
Signal transduction and amplification through enzyme-triggered ligand release and accelerated catalysis
Authors: Goggins Sean , Marsh Barrie J. , Lubben Anneke T. , Frost Christopher G.
Published: June 2015

An enzyme-triggered catalytic signal amplification cascade is described through the design of a novel enzyme substrate that selectively activates an organometallic transfer hydrogenation catalyst once triggered.
MoS2 nanosheets decorated with gold nanoparticles for rechargeable Li–O2 batteries
Authors: Zhang Panpan , Lu Xueyi , Huang Ying , Deng Junwen , Zhang Lin , Ding Fei , Su Zhiqiang , Wei Gang , Schmidt Oliver G.
Published: June 2015

MoS2 nanosheets decorated with gold nanoparticles show enhanced specific capacity and cycle efficiency for rechargeable Li–O2 batteries.
Facile synthesis of carbon nanodots from ethanol and their application in ferric(iii) ion assay
Authors: Miao Peng , Tang Yuguo , Han Kun , Wang Bidou
Published: June 2015

A one-pot synthesis approach is used to prepare carbon nanodots by electrochemical carbonization of ethanol under basic conditions. These materials are further applied in the fabrication of a Fe3+ biosensor.
Self-assembly of β-alanine homotetramer: formation of nanovesicles for drug delivery
Authors: Goel Rahul , Gopal Swarita , Gupta Alka
Published: June 2015

The present paper describes the fabrication of nanovesicles using the stirring induced self-assembly of a β-alanine homotetramer (H2N–βAla–βAla–βAla–βAla–CONH2) in an aqueous medium.
Highly sensitive polymer photodetectors with a broad spectral response range from UV light to the near infrared region
Authors: Wang Wenbin , Zhang Fujun , Li Lingliang , Zhang Miao , An Qiaoshi , Wang Jian , Sun Qianqian
Published: June 2015

Highly sensitive polymer photodetectors with a broad spectral response range from UV light to the near infrared region based on P3HT : PTB7-Th : PC71BM as the active layer are reported.
Semiconductor optical amplifiers in negative‐exponential fading: regenerators and pre‐amplifiers
Authors: Sagias Nikos C. , Yiannopoulos Kostas , Boucouvalas Anthony C.
Published: June 2015

In this study, the authors discuss the mitigation of negative‐exponential fading in optical wireless communication systems. The mitigation technique involves the utilisation of a semiconductor optical amplifier (SOA) that, depending on the link arrangement, acts either as regenerator or pre‐amplifier. As a regenerator, the SOA gain saturates during normal link operation and increases when the link experiences a fade. This unbalanced SOA operation serves towards the equalisation of the signal power at its output and fades become less severe and of reduced duration. The analytical results predict that the fade probability is reduced by over 90% and the scintillation index is improved by 75% for an optimal level of the received power. Moreover, the average duration of fades is also reduced by 68% for the same power level. As a pre‐amplifier, the SOA modifies the noise statistics at the receiver and provides a static sensitivity increase of at least 10 dB at 10 Gb/s, depending on the bit‐error‐rate (BER) target. The analytical results show that this sensitivity improvement imparts a reduction of one order of magnitude on the average BER, of at least 94% on the outage probability and of at least 78% on the average duration of fades.