bluuebunny/crossref_metadata_2025 huggingface dataset:
Understanding Internationalization at Home: Perspectives from the Global North and South
Authors: Almeida Joana , Robson Sue , Morosini Marilia , Baranzeli Caroline
Published: October 2018

Internationalization at Home (IaH) has become a strategic priority in higher education research, policy and practice, although there is still a lack of conceptual clarity around its meaning and practical applications and implications.

This paper aims to shed empirical insight into how this concept is understood by higher education staff. It follows a multiple-case study design to explore bottom-up understandings of IaH by 18 staff in two universities in Brazil and the UK. Findings yielded by a thematic analysis of two focus group sessions forefront three dimensions when enacting an IaH agenda: (1) the institutional or organizational side of internationalization, (2) teaching and learning aspects, and (3) personal experiences of the social actors involved in internationalization processes. Within these dimensions, four baseline features should be considered for a bottom-up understanding of IaH: institutional strategizing, international curricula, student integration, and inclusivity of IaH.

Implications for future research highlight the importance of furthering empirically grounded definitions of IaH via a bottom-up and top-down development of the concept that clarifies the epistemology of equity it represents. Implications for practice point to the urge of attending to staff perceptions whilst exploring macro-, meso- and micro-contextual conditions and needs.
A Novel Use of Honey’s Aggregation Approach to the Analysis of Repertory Grids
Authors: Rojon Céline , McDowall Almuth , Saunders Mark N. K.
Published: October 2018

This article examines and appraises a novel approach for generating shared group constructs through aggregative analysis: the application of Honey’s aggregation procedure to repertory grid technique (RGT) data. Revisiting personal construct theory’s underlying premises and adopting a social constructivist epistemology, we argue that, while “implicit theories” of the world, elicited via RGT, are unique to individuals, the constructs on which they are founded may be shared collectively. Drawing on a study of workplace performance, we outline a protocol for this novel use of Honey’s approach, demonstrating how it can be utilized to generate shared constructs inductively to facilitate theory building. We argue that, unlike other grid aggregation processes, the approach does not compromise data granularity, offering a useful augmentation to traditional idiographic approaches examining individual-level constructs only. This approach appears especially suited to addressing complex and implicit topics, where individuals struggle to convey thoughts and ideas.
Fabrication and characterization of tailor-made novel electrospun fibrous polyurethane scaffolds decorated with propolis and neem oil for tissue engineering applications
Authors: Jaganathan Saravana Kumar , Mani Mohan Prasath , Rathanasamy Rajasekar , Prabhakaran Praseetha
Published: October 2018

Recently, textile technologies have gained a huge attention for fabricating the tissue constructs. In tissue engineering, the development of biodegradable polymer scaffolds which resemble the native function of the extra cellular matrix is a great challenge. In this research, a novel electrospun scaffold based on polyurethane, propolis and neem oil was developed for tissue-engineering applications through textile technology like electrospinning. The morphology of the electrospun polyurethane/propolis and polyurethane/propolis/neem oil exhibited reduced fibre and pore diameter than the pristine polyurethane. The change in the chemical structure of the electrospun composites was identified by peak shifting of CH band peak with hydrogen bond formation.The contact angle measurements revealed that the PU/propolis mat was found to be super hydrophilic (0°) in nature and the electrospun polyurethane/propolis/neem oil mat was observed to be hydrophilic (41° ± 1) in nature. Thermogravimetric analysis and atomic force microscopy analysis showed that the prepared polyurethane/propolis and polyurethane/propolis/neem oil mats exhibited higher thermal stability and decreased surface roughness than the pristine polyurethane. Moreover, the developed polyurethane/propolis (activated partial thromboplastin time – 144 ± 4 s and prothrombin time – 85 ± 3 s) and polyurethane/propolis/neem oil (activated partial thromboplastin time – 147 ± 3 s and prothrombin time – 86 ± 2 s) composite displayed decreased blood clotting time than the pristine polyurethane (activated partial thromboplastin time – 153 ± 3 s and prothrombin time – 89 ± 3 s). The results of the haemolytic assay indicated that the electrospun polyurethane/propolis (1.21%) and polyurethane/propolis/neem oil (1.30%) mats exhibited better safety to red blood cells than the pristine polyurethane (2.48%). Hence, these desirable characteristics of the newly developed scaffold might be used as a potential platform for tissue engineering applications.
The Life and Career of William F. Cramer: Pedagogue, Scholar, and Performer
Authors: Hudson Michael W.
Published: October 2018

The purpose of this investigation was to provide a thorough documentation of the life and career of William F. Cramer. William Cramer was professor of trombone at the Florida State University for more than thirty-five years. He was a master teacher, musician, and scholar. His students remember him fondly as a grandfatherly figure whose teaching had positive impacts on their lives and careers as music educators. Cramer’s contributions to the field of music education, music performance, and scholarship are highlighted throughout this narrative. Former students, colleagues, friends, and family members served as primary sources in the gathering of information on the life and career of William F. Cramer.
Swimming performance index based on extreme value theory
Authors: Gomes Daniel T , Henriques-Rodrigues Lígia
Published: October 2018

The International Swimming Federation has developed a points system that allows comparisons of results between different events. Such system is important for several reasons, since it is used as a criterion to rank swimmers in awards and selection procedures of national teams. The points system is based entirely on the world record of the correspondent event. Since it is based on only one observation, this work aims to suggest a new system, based on the probability distribution of the best performances in each event. Using extreme value theory, such distribution, under certain conditions, converges to a generalized Pareto distribution. The new performance index, based on the peaks over threshold methodology, is obtained based on the exceedance probabilities correspondent to the swimmers’ times that exceed a given threshold. We work with 17 officially recognized events in 50 m pool, for each women and men, and considered all-time rankings for all events until 31 December 2016. A study on the adequacy of the proposed generalized Pareto distribution index and a comparison between the performances of Usain Bolt and Michael Phelps are also conducted.
Exploring the skill of recruiting in the Australian Football League
Authors: MacMahon Clare , Bailey Aisling , Croser Morag , Weissensteiner Juanita
Published: October 2018

The present study was designed to explore the skill of recruiting in the professional Australian Football League, with a particular interest in the approach to decision making and information processing. The research design utilised semi-structured interviews and a survey instrument. A total of 12 participants comprised of 11 active head recruiters representing 11 Australian Football League Clubs, and one former expert Australian Football League recruiter undertook semi-structured, in-depth interviews to provide insight into recruitment decision making. Additionally, all participants completed a survey determining preferences for intuitive and deliberative decision-making styles. A model created represents the identification of four influential factors in the recruitment approach including (a) recruiter background; (b) recruiter attributes; (c) recruiter understanding of team needs and (d) recruiter–coach relationship. In particular, recruiters revealed that the style of decision making they use is influenced by the relationship with the head coach. Recruiting as a stand-alone position is not well understood. This work shows that both intuition and deliberation are used, the extent to which appears to be influenced by the recruiter–coach relationship. This work offers a strong base to further explore recruiting and talent identification in professional sport, and, particularly, how relationships influence decision style and performance.
A cross-sectional study of long-term satisfaction after surgery for congenital syndactyly: does skin grafting influence satisfaction?
Authors: Ferrari Bien R. , Werker Paul M.N.
Published: October 2018

Syndactyly correction without skin grafting is advocated because it prevents graft-related complications and donor site morbidity. In this cross-sectional study, we compared satisfaction among patients who underwent correction with and without skin grafting to determine preference based on subjective and objective parameters. Retrospective chart analysis was performed among 27 patients (49 webs) who were seen at follow-up after a median follow-up period of 7.4 years, at which the Patient and Observer Scar Assessment Scale, the Withey score and a satisfaction survey were used. Notably, there were no significant differences in complication rates or observer rated scar scores. Although the need for an additional surgical procedure was higher after skin grafting, patient-rated satisfaction scores were similar irrespective of the use of grafting. Our data suggest that corrections can best be performed without skin grafts if seeking to minimize the need for an additional procedure, but that the use of skin grafts does not appear to affect patient satisfaction.

Level of evidence: IV
Enacting a parallel world: Political protest against the transnational constellation
Authors: Volk Christian
Published: October 2018

Global capitalism is a transnational “operational space” (Sassen) which is (re)produced by the practices of states, policy- and issue-specific government networks, and private organizations such as transnational corporations, global law firms, and standard-setting agencies. This “operational space,” which I call the transnational constellation, works through and beyond distinct spatial settings (i.e. local, glocal, national, global), endowing them with a global financial capitalistic logic and limiting the scope of democratic self-determination. In the second section, I analyze political protest against this transnational constellation in terms of democratic theory. I argue that transnational protest and activism have to be appreciated for their reshaping of spaces of the political, for developing and delivering a genuinely global perspective on political problems, and for their politicization of the transnational constellation by revealing and contesting structures and strategies of domination. However, it would be misleading to conceive of protest against the transnational constellation as constituent power. Instead, as I argue in the third part of the article, this kind of protest enacts a parallel world which very often lasts only for a fleeting moment, but where alternative political and social life forms are exercised and experienced. Perhaps their time is yet to come.
Forecasting of demand using ARIMA model
Authors: Fattah Jamal , Ezzine Latifa , Aman Zineb , El Moussami Haj , Lachhab Abdeslam
Published: October 2018

The work presented in this article constitutes a contribution to modeling and forecasting the demand in a food company, by using time series approach. Our work demonstrates how the historical demand data could be utilized to forecast future demand and how these forecasts affect the supply chain. The historical demand information was used to develop several autoregressive integrated moving average (ARIMA) models by using Box–Jenkins time series procedure and the adequate model was selected according to four performance criteria: Akaike criterion, Schwarz Bayesian criterion, maximum likelihood, and standard error. The selected model corresponded to the ARIMA (1, 0, 1) and it was validated by another historical demand information under the same conditions. The results obtained prove that the model could be utilized to model and forecast the future demand in this food manufacturing. These results will provide to managers of this manufacturing reliable guidelines in making decisions.
Flow, Achievement Level, and Inquiry-Based Learning
Authors: Borovay Lindsay A. , Shore Bruce M. , Caccese Christina , Yang Ethan , Hua Olivia (Liv)
Published: October 2018

Beyond cognitive outcomes, inquiry instruction can have positive general and differentiated affective outcomes. In this exploratory study, teacher-nominated high- to low-average achievers in Grades 5 through 9 ( N = 272, mean age 11.7 years), in classrooms exhibiting rare, occasional, and frequent inquiry qualities, were assessed on Csikszentmihalyi’s construct of flow, following a recent unit and reflecting on their favorite subject. We focused on flow because it addresses education and life in general, and flow and inquiry invoke challenge and persistence. Interviews complemented these data. High-achieving participants reported most flow in inquiry and in their favorite subjects; in both situations, they could participate in determining the content. All students reported greater flow in inquiry-based activities and environments, and in their favorite subjects versus recent units. All preferred challenging over easy work although for different reasons. All highlighted feeling able to succeed and interest in an activity to experience flow.
Influence of impactor nature, mass, size and shape on ballistic resistance of mild steel and Armox 500 T steel
Authors: Kasilingam Senthil , Iqbal Mohd Ashraf , Senthil Rupali
Published: October 2018

This study is based on the finite element investigation of the response of mild steel and Armox 500 T steel targets subjected to macro- and micro-size impactor. The simulations were carried out on target against penetrator with varying masses, sizes, shapes and different nature (rigid and deformable projectiles) using ABAQUS/Explicit. The material parameters of Johnson–Cook elasto-viscoplastic model were employed for predicting the behaviour of the target. The impact resistance of mild steel and Armox 500 T steel plates has been studied against flat nose having masses of 4, 8, 13.5, 27, 32 and 64 kg. The influence of temperature has also been studied numerically for particular penetrator. To study the influence of nature of projectile, the simulations were performed on mild steel and Armox 500 T steel targets against deformable 2024 aluminium flat, hardened steel flat and hardened steel conical impactors at 950 and 150 m/s incidence velocities. Also, the simulations were carried out on given target against 7.62 and 12.7 mm armour piercing incendiary ogival nose projectiles. The performance of (4.7 + 4.7 mm) 9.4-mm-thick equivalent mild steel and Armox 500 T steel plate in combination has also been studied against 7.62 armour piercing incendiary ogival nose projectiles at 950 and 150 m/s incidence velocities. The study thus presents a detailed investigation in terms of penetration, perforation and failure mechanism of mild steel and Armox 500 T steel target and leads to some important conclusions pertaining to the force and resistance offered by the target.
The playeur and Pokémon Go: Examining the effects of locative play on spatiality and sociability
Authors: Evans Leighton , Saker Michael
Published: October 2018

Pokémon Go is a hugely popular hybrid reality game (HRG) that enables players to occupy a space that is simultaneously physical and digital. The general aim of Pokémon Go is to discover and then capture Pokémon. This article reports on an original research project designed to explore the impact of Pokémon Go on spatiality and sociability. The project was conducted between May 2017 and July 2017, using an online survey which received 375 responses from users of Pokémon Go geographically spread across the globe. Drawing on the concept of the “playeur” as an established approach to understanding the effects of locative play on spatiality and sociability, this research follows three lines of enquiry. First, the research examines whether the intermingling of play and ordinary life might encourage players to spend more time outside in public spaces, and how this mode of play is experienced. Second, the research explores whether the game mechanics of Pokémon Go might lead players to traverse their environment using modified routes, as well as to frequent new places. Third, the research examines whether the praxis of Pokémon Go might enable new forms of sociability to emerge that extend beyond earlier HRGs.
Alpha defensin, leukocyte esterase, C-reactive protein, and leukocyte count in synovial fluid for pre-operative diagnosis of periprosthetic infection
Authors: De Vecchi Elena , Romanò Carlo Luca , De Grandi Roberta , Cappelletti Laura , Villa Francesca , Drago Lorenzo
Published: October 2018

Synovial fluid analysis for diagnosis of prosthetic joint infections has gained increasing interest in the recent past when markers more specific for these infections than the serum ones have been identified. Despite the important steps forward, identification of a gold standard has not yet been identified. In this study, usefulness of alpha defensin, leukocyte esterase, C-reactive protein (CRP), and white blood cells (WBCs) in synovial fluids alone and in combination for diagnosis of prosthetic joint infection was evaluated. Synovial fluids from 32 infected and 34 not infected patients were analyzed. Sensitivity, specificity, positive and negative predictive values, diagnostic accuracy, and receiver-operating characteristic (ROC) curves were calculated for each parameter. Moreover, combination of coupled variables was also evaluated by logistic regression analysis. Sensitivity of alpha defensin, CRP, leukocyte count, and leukocyte esterase were 84.4%, 87.5%, 93.7%, and 93.8%, respectively. Specificity was 91.2% for leukocyte counts, 94.1% for alpha defensin, 97.0% for CRP, and 97.1% for leukocyte esterase. Diagnostic accuracy was 89.4% for alpha defensin, 92.4% for WBC counts and CRP, and 95.5% for leukocyte esterase. No statistical differences were observed in area under the curve (AUC) of the ROC curves of alpha defensin, CRP, and leukocyte counts. Logistic regression analysis applied to a model comprising all the variables showed an AUC higher than AUC of coupled variables. In conclusion, results of this study confirm the high sensitivity and specificity of synovial leukocyte esterase for diagnosis of prosthetic joint infection, also suggesting the need to assess a panel of markers to optimize diagnosis of these infections.
Carboplatin–Angelica gigas Nakai combination synergistically enhances apoptosis by suppressed Akt, Erk, and Stat3 expression in H460 human lung cancer cells
Authors: Ku Jin Mo , Hong Se Hyang , Kim Hyo In , Jung Jun Seok , Jung Myung Ju , Kim Ji Hye , Seo Hye Sook , Shin Yong Cheol , Ko Seong-Gyu
Published: October 2018

The lower potency of low dose of carboplatin often requires combination with other drugs to improve its efficacy. Newer and more potent carboplatin-based combination therapies are investigated for treatment. We investigated whether paclitaxel, carboplatin, and Angelica gigas Nakai (AGN) affect viability of H460 cells by MTT assay. Western blot analysis was used to measure the expression of various modulators, such as p-Stat3, p-Akt, and p-Erk. Paclitaxel, carboplatin, and AGN affected the viability of H460 cells. Paclitaxel, carboplatin, and AGN suppressed p-Akt, p-Erk, and p-Stat3 expression. AGN combined with carboplatin significantly decreased c-Jun, HIF-1α, and VEGF levels. AGN combined with carboplatin significantly increased p21 and p27 levels and suppressed cyclin D1 and cyclin E levels. AGN combined with carboplatin-induced apoptosis by increasing Bax and cleavage of caspase and Parp level and by suppressing Bcl-2 level. Our results clearly demonstrate that AGN combined with carboplatin could be a useful compound for treating lung cancer.
Multimodal and Spectral Degradation Effects on Speech and Emotion Recognition in Adult Listeners
Authors: Ritter Chantel , Vongpaisal Tara
Published: October 2018

For cochlear implant (CI) users, degraded spectral input hampers the understanding of prosodic vocal emotion, especially in difficult listening conditions. Using a vocoder simulation of CI hearing, we examined the extent to which informative multimodal cues in a talker’s spoken expressions improve normal hearing (NH) adults’ speech and emotion perception under different levels of spectral degradation (two, three, four, and eight spectral bands). Participants repeated the words verbatim and identified emotions (among four alternative options: happy, sad, angry, and neutral) in meaningful sentences that are semantically congruent with the expression of the intended emotion. Sentences were presented in their natural speech form and in speech sampled through a noise-band vocoder in sound (auditory-only) and video (auditory–visual) recordings of a female talker. Visual information had a more pronounced benefit in enhancing speech recognition in the lower spectral band conditions. Spectral degradation, however, did not interfere with emotion recognition performance when dynamic visual cues in a talker’s expression are provided as participants scored at ceiling levels across all spectral band conditions. Our use of familiar sentences that contained congruent semantic and prosodic information have high ecological validity, which likely optimized listener performance under simulated CI hearing and may better predict CI users’ outcomes in everyday listening contexts.
Co-creating Value in People’s Interactions with Cognitive Assistants: A Service-System View
Authors: Siddike Md Abul Kalam , Kohda Youji
Published: October 2018

Purpose—The main purpose of this study was to develop a service-system framework in which people interact with cognitive assistants (CAs) for co-creation of value, such as enhanced communication and better task management.

Methodology—Qualitative research was undertaken to deeply investigate and explore the value co-created through people’s interactions with CAs. A total of 32 interviews were conducted in three phases. The interview data were analysed using MAXQDA 12.

Results—The results of this study indicate that most of the users use Apple’s Siri, Amazon Eco or Google Home as their CAs and that people’s interactions with CAs are influenced by their trust in and relative advantages of using CAs. The results also indicate that a diversity of value, such as enhanced communication, better task management, enhanced information retrieval, enhanced learning and better data-driven decisions, is co-created through interactions between people and CAs.

Implications—We developed a service-system framework in which CAs are considered as actors and introduced the concept of ‘autonomous agency’ for controlling and coordinating people’s interactions with CAs.

Originality—This is the first study on the value co-creation from people’s interactions with CAs (artificial-intelligence-based systems) by proposing a service-system framework in which CAs are considered as actors.
Consumer Brand Value Co-creation Typology
Authors: Guzmán Francisco , Paswan Audhesh K. , Kennedy Eric
Published: October 2018

Co-creation is said to take place in a variety of domains when two or more actors interact to create value. The topic of brand co-creation has been in the literature for 15 years. During this time, a multitude of concepts, constructs and behaviours about co-creation have been presented in the marketing literature. The result is a fragmented research area with little underlying consensus about how co-creation occurs between consumers and brands. The purpose of this article is to propose a brand co-creation typology, with the goal of consolidating existing work into a unified framework and providing a roadmap for practitioners to use co-creation in a more informed fashion. This typology creates avenues for future research through empirical testing.
Fidelia Fiske and the School for Girls at Urmia, Persia (1843–1858)
Authors: Khamushi Musa
Published: October 2018

In 1843 Fidelia Fiske went as a missionary with the American Board of Commissioners for Foreign Missions to Urmia, Persia, to work among Nestorian girls and women. A girls’ school had been established there in 1838, but following its founder’s death it required new leadership. Under Fiske the number of students increased, and the school became a center for educating and evangelizing Nestorian girls and young women. This article considers Fiske’s contribution to expanding and stabilizing the school.
Variability of Burnout and Stress Measures in Pediatric Residents: An Exploratory Single-Center Study From the Pediatric Resident Burnout–Resilience Study Consortium
Authors: Reed Suzanne , Kemper Kathi J. , Schwartz Alan , Batra Maneesh , Staples Betty B. , Serwint Janet R. , McClafferty Hilary , Schubert Charles J. , Wilson Paria M. , Rakowsky Alex , Chase Margaret , Mahan John D.
Published: October 2018

Residency is a high-risk period for physician burnout. We aimed to determine the short-term stability of factors associated with burnout, application of these data to previous conceptual models, and the relationship of these factors over 3 months. Physician wellness questionnaire results were analyzed at 2 time points 3 months apart. Associations among variables within and across time points were analyzed. Logistic regression was used to predict burnout and compassionate care. A total of 74% of residents completed surveys. Over 3 months, burnout ( P = .005) and empathy ( P = .04) worsened. The most significant cross-sectional relationship was between stress and emotional exhaustion (time 1 r = 0.61, time 2 r = 0.68). Resilience was predictive of increased compassionate care and decreased burnout ( P < .05). Mindfulness was predictive of decreased burnout ( P < .05). Mitigating stress and fostering mindfulness and resilience longitudinally may be key areas of focus for improved wellness in pediatric residents. Larger studies are needed to better develop targeted wellness interventions.
Three-Year Outcomes With Hypofractionated Versus Conventionally Fractionated Whole-Breast Irradiation: Results of a Randomized, Noninferiority Clinical Trial
Authors: Shaitelman Simona F. , Lei Xiudong , Thompson Alastair , Schlembach Pamela , Bloom Elizabeth S. , Arzu Isidora Y. , Buchholz Daniel , Chronowski Gregory , Dvorak Tomas , Grade Emily , Hoffman Karen , Perkins George , Reed Valerie K. , Shah Shalin J. , Stauder Michael C. , Strom Eric A. , Tereffe Welela , Woodward Wendy A. , Amaya Diana N. , Shen Yu , Hortobagyi Gabriel N. , Hunt Kelly K. , Buchholz Thomas A. , Smith Benjamin D.
Published: October 2018

Purpose

The adoption of hypofractionated whole-breast irradiation (HF-WBI) remains low, in part because of concerns regarding its safety when used with a tumor bed boost or in patients who have received chemotherapy or have large breast size. To address this, we conducted a randomized, multicenter trial to compare conventionally fractionated whole-breast irradiation (CF-WBI; 50 Gy/25 fx + 10 to 14 Gy/5 to 7 fx) with HF-WBI (42.56 Gy/16 fx + 10 to 12.5 Gy/4 to 5 fx).

Patients and Methods

From 2011 to 2014, 287 women with stage 0 to II breast cancer were randomly assigned to CF-WBI or HF-WBI, stratified by chemotherapy, margin status, cosmesis, and breast size. The trial was designed to test the hypothesis that HF-WBI is not inferior to CF-WBI with regard to the proportion of patients with adverse cosmetic outcome 3 years after radiation, assessed using the Breast Cancer Treatment Outcomes Scale. Secondary outcomes included photographically assessed cosmesis scored by a three-physician panel and local recurrence-free survival. Analyses were intention to treat.

Results

A total of 286 patients received the protocol-specified radiation dose, 30% received chemotherapy, and 36.9% had large breast size. Baseline characteristics were well balanced. Median follow-up was 4.1 years. Three-year adverse cosmetic outcome was 5.4% lower with HF-WBI ( Pnoninferiority = .002; absolute risks were 8.2% [n = 8] with HF-WBI v 13.6% [n = 15] with CF-WBI). For those treated with chemotherapy, adverse cosmetic outcome was higher by 4.1% (90% upper confidence limit, 15.0%) with HF-WBI than with CF-WBI; for large breast size, adverse cosmetic outcome was 18.6% lower (90% upper confidence limit, −8.0%) with HF-WBI. Poor or fair photographically assessed cosmesis was noted in 28.8% of CF-WBI patients and 35.4% of HF-WBI patients ( P = .31). Three-year local recurrence-free survival was 99% with both HF-WBI and CF-WBI ( P = .37).

Conclusion

Three years after WBI followed by a tumor bed boost, outcomes with hypofractionation and conventional fractionation are similar. Tumor bed boost, chemotherapy, and larger breast size do not seem to be strong contraindications to HF-WBI.
Deciphering V̇O2,max: limits of the genetic approach
Authors: Hoppeler Hans
Published: October 2018

Maximal oxygen consumption (V̇O2,max) denotes the upper limit of aerobic energy flux through the cascade of oxygen transfer from the environment to tissue mitochondria, essentially to skeletal muscle mitochondria during intense exercise. A high V̇O2,max is a key component for athletic success in human and animal endurance sports. From a public health perspective, a high V̇O2,max is a validated negative predictor for cardiovascular disease and all-cause mortality. V̇O2,max varies by more than twofold between sedentary subjects and shows a heritability value greater than 50%. Likewise, the capacity for an individual's V̇O2,max to be increased with exercise training (i.e. its trainability) varies massively between subjects, independent of each subject's V̇O2,max in the absence of training (i.e. their sedentary V̇O2,max), and with a similarly high heritability. Athletic as well as public health interests have prompted a search for the genetic profile of sedentary V̇O2,max and of trainability. Candidate-gene studies, gene-expression studies and genome-wide-association studies (GWAS) have not been able to identify a genetic signature that distinguishes subjects or athletes with a favorable V̇O2,max phenotype or a high trainability from controls. Here, I propose that multigenetic phenotypes such as V̇O2,max are emergent properties of multiple underlying transcriptomic networks modified by epistasis, the epigenome and the epitranscriptome. The genetic approach is thus considered to be necessary but insufficient for furthering our understanding of multigenetic higher-level functions.
Contrato administrativo de prestação de serviço executado de forma contínua: prorrogação de prazo efetuada após seu termo final
Authors: Sarai Leandro
Published: October 2018

Administrative contract for the provision of service performed continuously: deadline extension made after its final term O presente artigo, de natureza dogmática, elaborado segundo o método hipotético-dedutivo, analisa a prorrogação do contrato administrativo de prestação de serviços executados de forma contínua. A hipótese tomada para análise é a de que é possível essa prorrogação, ainda que o contrato esteja vencido. Para tanto, analisa o que justificaria a prorrogação desses contratos de modo geral, os problemas envolvidos com os contratos de prazo mais longo, o que caracterizaria os serviços executados de forma contínua, além da possibilidade de contratos com esse tipo de objeto terem vigência superior a 12 meses. Efetua ainda uma distinção entre contratos com prazo determinado e contratos por escopo. Finalmente, após verificar que a preocupação da lei em tratar as prorrogações como exceções decorre da vigência anual do orçamento e que o próprio sistema jurídico reconheceria a existência de despesas que ultrapassariam o exercício, conclui que não há vedação à prorrogação do contrato após seu termo final, desde que atendidas certas condições. This paper, of dogmatic nature and using the hypothetical-deductive reasoning, explores the term extension of administrative contracts made after its expiration. The focus is on contracts of services that are performed continuously. The main hypothesis is that the term extension is possible. To treat this issue, it studies what justifies the extension of such contracts in general, the problems involved with longer-term contracts, the distinguish element of services that are performed continuously, besides the possibility of contracts with this type of object having duration exceeding 12 months. It makes a distinction between fixed term contracts and contracts for scope. Finally, after checking that the concern of the law in dealing with extensions as exceptions are due to the annual duration of the budget and that the legal system recognizes the existence of expenses that exceed this duration, it points out that there is no prohibition to the contract’s deadline extension made after its expiration, provided that certain conditions are fulfilled.
Improbidade administrativa por dispensa indevida de licitação: sobre os efeitos da desatualização dos valores limites para dispensa de licitação
Authors: Cristóvam José Sérgio da Silva , Silva Eliza Maria da
Published: October 2018

Administrative improbity due to improper waiver of bidding: on the effects of the devaluation of limit values for waiver of bidding O presente estudo pretende analisar o conceito de dispensa de licitação em razão do valor ante o fator de instabilidade econômica a ela inerente, observando as normas constitucionais e infraconstitucionais vigentes. Para tanto, discutem-se os parâmetros de dosagem e configuração do ato de improbidade por dispensa indevida de licitação (ante a necessidade de atualização dos valores limites das modalidades licitatórias), bem como as sanções e penalidades dela decorrentes. Prima-se, nessa análise, pelo debate pautado em parâmetros como a razoabilidade e a proporcionalidade, segundo os quais são incluídas, necessariamente, a análise conjunta das normas que prescrevem o ilícito administrativo (pelo viés unificado do ordenamento jurídico), bem como a valoração da lesividade da conduta — conduzida pelos ditames do princípio da insignificância. O método utilizado é o dedutivo e monográfico, e a técnica de pesquisa é bibliográfica. This study intends to analyze the concept of waiver of bidding due to the value under the light of its inherent fact of economic instability, observing the constitutional and infra-constitutional current regulations. For so, it is discussed the parameters of dosing and configuration of the improbity act for improper waiver of bidding (towards the need of the limit values actualization for bidding modalities), and its stemming sanctions and penalties. This analysis excels the debate founded on the reasonableness and proportionality parameters, in what are included, necessarily, the joint analysis of the norms that prescribe the ilegal administrative (by the unified bias of legal system), as well as the valuation of conduct lesivity — led by the precepts from the principle of insignificance. The method and technique used are, respectively, the deductive and monographic, and the bibliographic research.
A indispensável coisa julgada administrativa
Authors: Moreira Egon Bockmann , Gomes Gabriel Jamur
Published: October 2018

The indispensable administrative preclusion (res judicata) O artigo revisa e reelabora o conceito de coisa julgada administrativa, compatibilizando-o com a realidade constitucional brasileira. Além disso, verifica seus parâmetros de aplicabilidade, bem como os precedentes do Supremo Tribunal Federal (STF) e do Superior Tribunal de Justiça (STJ) acerca da matéria. The article reviews and re-elaborates the concept of administrative res judicata, making it compatible with the Brazilian constitutional reality. Besides, the article verifies its applicability parameters, and the precedents of the Federal Supreme Court (STF) and the Superior Court of Justice (STJ).
DomainBuilder: the knowledge authoring system for SlideTutor Intelligent Tutoring system
Authors: Tseytlin Eugene , Linkov Faina , Castine Melissa , Legowski Elizabeth , Jacobson Rebecca S.
Published: October 2018

One of the major challenges in the development of medical Intelligent Tutoring Systems (ITS) is the development of authored content, a time-consuming process that requires participation of discipline experts. In this publication, we describe the development of software systems called DomainBuilder and TutorBuilder, designed to streamline and simplify the authoring process for general medical ITSs. The aim of these systems is to allow physicians without programming or ITSs background to create a domain knowledge base and author tutor cases in a time efficient manner.  DomainBuilder combined knowledge authoring, case authoring, and validation tasks into a single work environment, enabling multiple authoring strategies. Natural Language Processing (NLP) methods were integrated for parsing existing clinical reports to speed case authoring. Similarly, TutorBuilder was designed to allow users to customize all aspects of ITSs, including user interface, pedagogic module, feedback module, etc. Both systems underwent formal usability studies with physicians specializing in dermatology. Open-ended questions assessed usability of the system and satisfaction with its features. Incorporating feedback from usability studies, DomainBuilder and TutorBuilder systems were deployed and used across multiple universities to create customized medical tutoring curriculum. Overall, both systems were well received by medical professionals participating in usability studies with participants highlighting ease of utilization and clarity of presentation. Usability study participants were able to successfully use the system for the authoring tasks. DomainBuilder and TutorBuilder are novel tools that combine comprehensive aspects of content creation, including creation of domain ontologies, case authoring, and validation.
ALFRED ADLER (1870-1937): Uma breve biografia
Authors: Leal Daniela , Massimi Marina
Published: October 2018

Este artigo objetiva apresentar uma breve biografia do médico psiquiatra Alfred Adler, desde seu nascimento até o desenvolvimento de sua teoria, a Psicologia Individual, com o intuito de apontar algumas de suas contribuições para o desenvolvimento da área da Psicologia, assim como a relação observada entre a criação dos conceitos-chave de sua teoria com suas próprias vivências, ao longo de seus 67 anos de vida. Para tanto, optou-se por uma pesquisa de cunho histórico, seguindo a abordagem historiográfica proposta por De Certeau (2010). Por fim, observou-se que, tanto a atitude adotada frente à vida quanto a construção teórica da Psicologia Individual se constituíram por intermédio, primeiro, da harmonia existente entre os fatos vivenciados durante a infância de Adler: estreito círculo familiar e condições de saúde enfrentadas nos 5 primeiros anos de vida (raquitismo, pneumonia). Segundo que, um dos seus principais conceitos, o de sentimento de comunidade, foi sendo construído desde as primeiras relações estabelecidas com os colegas de rua e da escola, passando pelo relacionamento que estabelecia com seus pacientes no consultório e, chegando, à preocupação com a reconstrução social da educação de seu país.
EXPEDIENTE - v17n3
Authors: Soares Adriana Benevides , Tsallis Alexandra Cleopatre , Mendes Deise Maria Leal Fernandes , Valentim Renata Patrícia Forain de
Published: October 2018

EXPEDIENTE - v17n3
Terapia assistida por animais e transtornos do neurodesenvolvimento
Authors: Marinho Jéssica Riedi Souza , Zamo Renata De Souza
Published: October 2018

Este artigo visa levantar, por meio de construções teórico-científicas, os benefícios que a Terapia Assistida por Animais (TAA) pode gerar quando utilizada para tratamento com crianças que apresentam algum comprometimento neurodesenvolvimental. O contato humano-animal é conhecido desde a antiguidade, porém, apenas na atualidade estudos em torno deste viés estão crescendo. Portanto, foi realizada uma revisão crítica da literatura, analisando os dados coletados a partir de análise de conteúdo. Os resultados apontam o potencial benéfico deste tipo de intervenção com crianças com dificuldades sociais, cognitivas e físicas. Os animais mais utilizados são cachorros e cavalos para tratamento de crianças com Transtorno do Espectro Autista, Síndrome de Down e Deficiência Intelectual. Dessa forma, há uma possibilidade de que os profissionais da Psicologia, e de outras áreas da saúde, utilizem ou  encaminhem para a Terapia Assistida por Animais (TAA) seus pacientes. Ainda assim, conclui-se que há a necessidade de mais estudos empíricos.
Revisiting Sándor Ferenczi in light of current educational practices
Authors: Sans Ana Inés Heras Monner
Published: October 2018

Analiso a orientação pedagógica de uma equipe de educadores que dirigem um centro educativo na cidade de Buenos Aires (CEIA), na Argentina, que fornece a instrução pública elementar a crianças, jovens e adultos que vivem em condições extremamente desafiantes (isto é, têm dificuldades em acessar o serviço de saúde básico, o trabalho, a educação e o alojamento). Concentro-me em estabelecer conexões entre o seu trabalho e aquela da noção original de Sandor Ferenczi da análise mútua. Com esta finalidade, primeiro apresento alguns aspectos do contexto histórico no qual Ferenczi viveu e desenvolveu a sua teoria, mostrando que a mutualidade foi uma orientação que permeou a sua vida e trabalho. Assim analiso dois dispositivos pedagógicos identificados no CEIA na luz da armação da mutualidade, depois da qual apresento uma discussão que destaca a relação entre a aproximação dos educadores, que identifico como a noção de, e Ferenczi clínico e educativo da mutualidade. Concluo que as ideias de Ferenczi — a novela no momento —ainda é atual, se não novo, contanto que perguntemos o que pode aprender-se de eles. A minha metodologia combina uma perspectiva histórica com etnografia e sociolinguística em dois respeitos: análise da armação pedagógica dos educadores e exame de dados históricos naquela luz.
Encontro com a Psicanálise: experiências de estágio em uma clínica-escola
Authors: Bisol Cláudia Alquati , Alquatti Raquel , Gonem Thays Carvalho
Published: October 2018

A clínica-escola, enquanto espaço para realização de estágio em Psicologia Clínica, conjuga as dimensões da formação universitária e atendimento à comunidade. A Psicanálise é uma das modalidades clínicas e dispositivos teóricos que se apresentam aos estudantes como possibilidade para seu trabalho. Neste artigo, iniciamos problematizando as relações entre a Psicanálise e a Universidade, na tentativa de situar um lugar possível para a Psicanálise no contexto da formação em um curso de Psicologia. Em seguida, buscamos elementos para pensar a clínica nas recomendações de Freud aos jovens analistas. Por fim, articulamos estas questões à nossa experiência de estágio, realizado em uma clínica-escola de uma Universidade do sul do país. Consideramos que a desconstrução da lógica universitária em relação ao saber, a construção de uma escuta que não cede à linguagem e a atenção para o manejo das exigências institucionais são algumas das questões essenciais para um encontro possível dos estudantes com a Psicanálise.
Poorer radiological outcome after delayed diagnosis and treatment in human position in Fettweis plaster cast in 93 unstable hip joints type D, III and IV according to Graf
Authors: Kubo H. , Pilge H. , Holthoff J.-P. , Hufeland M. , Westhoff B. , Krauspe R.
Published: October 2018

Purpose

In this study the course of unstable hips after successful treatment with Fettweis plaster of Paris (POP) is examined. Special focus will be given to age at beginning of treatment and initial hip type.

Methods

The development of 93 unstable hips treated between November 2001 and April 2015 was examined. Inclusion criteria were: 1) unstable hips with successful treatment with Fettweis POP; 2) presence of two pelvic radiographs (12 to 24 months and 24 to 48 months). We analyzed: 1) the initial ultrasound hip type according to Graf; 2) the average age at first and second radiograph; 3) the Tönnis classification: normal findings (< 1 SD), slightly (1 SD to 2 SD) and severely dysplastic hips (> 2 SD).

Results

In all, there were 14 hips type D, 41 hips type III and 38 hips type IV. Mean age of the first radiograph was 13.9 months and of the second 28.5 months. The first radiograph showed: (< 1 SD): 36, (1 SD to 2 SD): 34, (> 2 SD): 23 hips, the second radiograph: (< 1 SD): 33, (1 SD to 2 SD): 19, (> 2 SD): 30 hips. With subdivision at the start of treatment at age eight or fewer weeks 2/16 hips (12.5%) and with initiation of the treatment more than eight weeks 22/77 (26.0%) deteriorated. During the course between first and second radiograph a total of 35.7% of initial hip type D, 19.5% of type III and 23.7% of type IV deteriorated.

Conclusion

Radiograph controls after treatment with Fettweis POP show poorer outcome after delaying the start of treatment more than 8 weeks. These findings were independent of the initial ultrasound hip type. Regular radiograph controls of all hip types treated for unstable hips are justified to detect residual dysplasia.

Level of evidence

IV
Subcellular Localization of Prolyl Endopeptidase During the First Wave of Rat Spermatogenesis and in Rat and Human Sperm
Authors: Venditti Massimo , Minucci Sergio
Published: October 2018

Prolyl endopeptidase (PREP) is an enzyme which cleaves several peptide hormones and neuropeptides on the carboxyl side of proline residues and is involved in many biological processes, including cell proliferation and differentiation, glucose metabolism, learning, memory, and cognitive disorders. PREP has also been identified as a binding partner of tubulin, suggesting the involvement of endopeptidase in microtubule-associate processes, independent of its peptidase activity. Furthermore, several reports have implied PREP participation in both male and female reproduction-associated mechanism. We herein assess a potential association of PREP to the morphogenesis of rat testis, profiling its localization versus tubulin, during the first wave of spermatogenesis and in the adult gonad (from 7 to 60 dpp). We show that, in mitotic phases, PREP shares its localization with tubulin in Sertoli cells, gonocytes, and spermatogonia. Later, during meiosis, both proteins are found in spermatocytes, and in the cytoplasm of Sertoli cells protrusions, surrounding the germ cells, while, during spermiogenesis, they both localize in the cytoplasm of round and elongating spermatids. We also found that this enzyme has a peculiar nuclear localization, in the proliferating cells in all phases of analysis. Finally, they are expressed in the flagellum of mature gametes, as corroborated by additional immunolocalization analysis on both rat and human sperm. Our data support the hypothesis of the fundamental role of PREP in reproduction and in cytoskeletal organization during mammalian testis morphogenesis and gamete progression.
The European Union and Latin America: The configuration of interregional and transatlantic cooperation
Authors: Tayar Violetta
Published: October 2018

This article analyses the European strategy of partnership towards Latin American and Caribbean countries during the twenty-first century. The author singles out the main stages (cycles) of the negotiation processes between the two regions and gives an assessment of the trade and economic relations and priorities existing on both sides of the Atlantic Ocean. Also examined are the possible risks and consequences for Latin American and Caribbean countries in the event of profound transatlantic cooperation between the European Union (EU) and the United States.