bluuebunny/crossref_metadata_2025 huggingface dataset:
Applications, Promises, and Pitfalls of Deep Learning for Fluorescence Image Reconstruction
Authors: Belthangady Chinmay , Royer Loic A.
Published: December 2018

Deep Learning is a recent and important addition to the computational toolbox available for image reconstruction in fluorescence microscopy. We review state-of-the-art applications such as image restoration, super-resolution, and light-field imaging, and discuss how the latest Deep Learning research can be applied to other image reconstruction tasks such as structured illumination, spectral deconvolution, and sample stabilisation. Despite its successes, Deep Learning also poses significant challenges, has often misunderstood capabilities, and overlooked limits. We will address key questions, such as: What are the challenges in obtaining training data? Can we discover structures not present in the training data? And, what is the danger of inferring unsubstantiated image details?
Special Issue on Integrated Knowledge on Innovative Robot Mechanisms
Authors: Takesue Naoyuki , Koganezawa Koichi , Tadakuma Kenjiro
Published: December 2018

A robot is a system integrated with many elements such as actuators, sensors, computers, and mechanical components. Currently, progress in the field of artificial intelligence induced by tremendous improvements in computer processing capabilities has enabled robots to behave in a more sophisticated manner, which is drawing considerable attention. On the other hand, the mechanism that directly produces robot movements and mechanical work sometimes brings out some competencies that cannot be provided solely by computer control that relies on sensor feedback.

This special issue on “Integrated Knowledge on Innovative Robot Mechanisms” aims to introduce a knowledge system for robot mechanisms that bring forth useful and innovative functions and values.

The editors hope that the studies discussed in this special issue will help in the realization and further improvement of the mechanical functions of robots in the real world.
Improved Artificial Bee Colony Algorithm and its Application in Classification
Authors: Wang Haiquan , Wei Jianhua , Wen Shengjun , Yu Hongnian , Zhang Xiguang ,   Zhongyuan Petersburg Aviation College, Zhongyuan University of Technology 41 Zhongyuan Road, Zhengzhou 450007, China,   School of Electric and Information Engineering, Zhongyuan University of Technology 41 Zhongyuan Road, Zhengzhou 450007, China,   Faculty of Science and Technology, Bournemouth University Fern Barrow, Poole, Dorset BH12 5BB, United Kingdom
Published: December 2018

For improving the classification accuracy of the classifier, a novel classification methodology based on artificial bee colony algorithm is proposed for optimal feature and SVM parameters selection. In order to balance the ability of exploration and exploitation of traditional ABC algorithm, improvements are introduced for the generation of initial solution set and onlooker bee stage. The proposed algorithm is applied to four datasets with different attribute characteristics from UCI and efficiency of the algorithm is proved from the results.
MENGEMBANGKAN KECERDASAN SPIRITUAL ANAK MELALUI PENDIDIKAN AGAMA
Authors: Yuliatun Yuliatun
Published: December 2018

Naturally, Every child born has brought potential for good, that will
foster a sense of potential and needs to know and close to Allah who created him.
Communication that is built will bring up commendable attitudes and always
incline to virtue. This is the characteristics of spiritual potential that contain high
values of humanity. The values will be wise and make coverage always attend
deep meaning and value in their actions. Religious education can be used as a
medium or tool to a activate children spiritual intelligence potency in addition to
their emotional and intelectual ones. This paper analyzes how the importance of
religious education which is reinforced by the meaning of each Islamic dimension
(faith, Islam, and ihsan) in every facet of human life.
MEMBANGUN KEPRIBADIAN ANAK DENGAN DONGENG
Authors: Vera Sophya Ida
Published: December 2018

Today, we can see that the negligence of parents and early childhood’s
teachers could not keep pace with the times. This can be seen from the
development of increasingly sophisticated technology and the rise of children’s
television programs become more interested. Given this phenomenon, the
parents and educators particularly in early childhood environment, should
be flashback while they are still at an early age. The existence of storytelling
activities tend to have waned since eroded by age and sophisticated era. Though
keep in mind that there are many benefits by giving a fairy tale to children.
Children’s tales are very useful for being able to glue the relationship between
parents and their children, as well as helping to optimize the development of
children’s psychological and emotional intelligence. The examples of fairy tales
that can be given to children is a tale of local knowledge that can be drawn
from the local legends and the unique stories.
The Leadership Style of “The People’s Doctor”: A Contemporary Look Back at New York State Commissioner of Health David Axelrod, MD
Authors: Magdon-Ismail Zainab , Sherman Barry R. , Fillmore Herbert , Straussman Jeffrey
Published: December 2018

David Axelrod, MD, New York State’s commissioner of health from 1979 to 1991, had a panoramic view of public health and a legendary track record of tackling complex issues ranging from the Love Canal environmental disaster to HIV/AIDS and end-of-life ethics. Many raved about Axelrod’s leadership, whereas others criticized his response and style. Two decades later, we describe his leadership attributes. Our retrospective review incorporates interviews with former staff and coworkers and information from historical archives. Axelrod’s leadership style mirrored that of business leaders, goal driven and focused on execution, as opposed to the typical style of public health leaders, more sympathetic to needs of the team. He framed his mission within the context of social justice and data-driven science. His story, one in which leadership inspired passion and loyalty to science, is driven by a laser-sharp focus on the public good. In today’s resource-deprived, politically charged environment, Axelrod’s methods for achieving positive community health outcomes warrant close scrutiny. (Am J Public Health. 2019;109:85–91. doi:10.2105/AJPH.2018.304710 )
Leishmaniasis, riesgo de reintroducción
Authors: Tello-Salgado David , Treviño-Garza Nancy , Navarrete-Sandoval Rafael Hernán , Sesma-Medrano Eduardo , Eroza-Osorio César Miguel , Carrillo-Valenzo Erik , Pérez-Robles Víctor Manuel , González-Fernández Mariana Irina
Published: December 2018

[No disponible]
Influence of Shale Conductivities on the Electrical Conductivity of Low-Permeability Rocks
Authors: Volk L. J. , Raible C. J. , Carroll H. B.
Published: December 2018

Introduction

Many of the wells now being drilled in the tight gas sands in the western U.S. are using potassium-based drilling muds to help stabilize the days being encountered. Consequently; there has been some concern that the potassium and sodium ions may behave differently in electric-logging. For example, in free water K + has an equivalent conductance almost 50% greater than the Na + ion at 25° C.

The. model proposed by Waxman and Smits 1 (WS) and the Dual-Water (D-W) model of Clavier et al.2 are those most commonly used to explain the conductivity of shaly formations. These models have been used primarily with the sodium counterion. In this report, these models are examined with data based on the potassium counterion.
Arthritis Prevention in the Pre-Clinical Phase of RA with Abatacept (the APIPPRA Study): A Multi-Centre, Randomised, Double Blind, Parallel Group Placebo-Controlled Clinical Trial
Authors: Al-Laith Mariam , Jasenecova Marianna , Abraham Sonya , Bosworth Aisla , Bruce Ian N. , Buckley Christopher D. , Ciurtin Coziana , D’Agostino Maria-Antonietta , Emery Paul , Gaston Hill , Isaacs John D. , Filer Andrew , Fisher Benjamin A. , Huizinga Thomas W. J. , Ho Pauline , Jacklin Clare , Lempp Heidi , McInnes Iain B. , Pratt Arthur G. , Östor Andrew , Raza Karim , Taylor Peter C. , Schaardenburg Dirkjan van , Shivapatham Dharshene , Wright Alison J. , Vasconcelos Joana C. , Kelly Joanna , Murphy Caroline , Prevost A. Toby , Cope Andrew P.
Published: December 2018

Background:
Individuals with joint pain and carrying serum autoantibodies associated with rheumatoid arthritis (RA) are at high risk of developing RA. While there are currently no evidence-based guidelines to inform therapy decisions for such subjects, there are therapies licensed for the treatment of established RA that target pathways implicated in the earliest phase of the disease. Accordingly, we set out to test the feasibility, acceptability and effectiveness of a 52-week period of treatment with the first in class costimulatory blocker abatacept for preventing or delaying the onset of inflammatory arthritis.
Methods and Design
The APIPPRA study was designed as a randomised, double blind, parallel group placebo-controlled clinical trial, aiming to recruit 206 male or female subjects from the secondary care hospital setting across the UK and the Netherlands. Participants aged 18 or over who report inflammatory sounding joint pain (clinically suspicious arthralgia) and who are found to be positive for serum autoantibodies associated with RA, will be randomised to receive weekly injections of investigational medicinal product (IMP), either abatacept or placebo treatment over a 52-week period. All study subjects consent to a further 52 weeks of follow up to monitor for the primary endpoint, the time to development of ≥ 3 swollen joints, or to the fulfillment of the 2010 ACR/EULAR classification criteria for RA using swollen but not tender joints, whichever endpoint is met first. In either case, swollen joints are confirmed by ultrasonography.
Discussion
There is limited experience of the design and implementation of trials for the prevention of inflammatory joint diseases. Here, we propose to explore the effects of immunomodulatory therapy at the very earliest detectable phase of disease using an intervention that is already licensed for use in established RA. We discuss the rationale behind choice and duration of treatment, the challenges associated with defining the “at risk” state, and offer pragmatic solutions in the protocol to enrolling subjects at risk of RA.
Trial registration
Current Controlled Trials, ID: ISRCTN46017566. Registered on 04 July 2014
Myasthenic Crisis Treated in a Neurological Intensive Care Unit: Clinical Features, Mortality, Outcomes, and Predictors of Survival
Authors: Liu Fan , Wang Qiong , Chen Xueping
Published: December 2018

Background: Myasthenic crisis (MC) often requires admission to an intensive care unit (ICU).
Methods: We retrospectively investigated 115 consecutive patients with first MC admitted to the neurological ICU. Patients’ demographic, clinical and other characteristics were examined, as well as therapeutic interventions; mortality and functional outcome.
Results: MC patients admitted to neurological ICU had a mortality rate of 24.34%. PCO2 level before intubation and score on Myasthenia Gravis–Activities of Daily Living (MG-ADL) scale at MC onset correlated with duration of ventilation and length of ICU stay. Compared with patients with good functional outcome, patients with intermediate or poor functional outcome were older at first MC onset, had lower pH and PO2, and had higher PCO2 before intubation. Multivariate logistic analysis identified pre-intubation PCO2 level as an independent predictor of survival. Cox regression showed that age at first MC onset requiring ICU management was the factor which significantly influenced the mortality. Conclusions: Our results suggest that PCO2 before intubation and MG-ADL score at MC onset may be useful indicators of more severe disease likely to require extensive respiratory support and ICU management. Higher pre-intubation PCO2 indicates chronic respiratory acidosis that can increase risk of severe disability and death, especially in patients with older age at first MC onset.
Clinical Features and Prognosis of Cerebral Venous Sinus Thrombosis during Pregnancy and Puerperium
Authors: Gai Qing , Leng Changmu , Cong Shuyan
Published: December 2018

Background: Cerebral venous sinus thrombosis (CVST) is a rare and serious complication during pregnancy and puerperium with a variety of clinical features. Little is known about the prognostic factors of CVST during the acute phase, subsequent pregnancy outcomes, and the risk of recurrence of CVST. The purpose of the study is to investigate the clinical features and prognosis of pregnancy-related CVST in China.
Methods: We retrospectively analyzed the clinical data of 41 patients diagnosed with CVST during pregnancy or puerperium from January 2007 through March 2018 in Shengjing Hospital. Poor outcome was defined as modified Rankin Scale (mRS) ³3 at discharge. Independent prognostic factors for CVST outcome were identified via multivariate logistic regression analysis. Long-term outpatient interview was followed to know the next pregnancies outcome and CVST relapse rate.
Results: CVST occurred about 2.4 times (29 vs. 12) during puerperium than in pregnancy. Headache (90%) was found the most common clinical feature, followed by focal neurologic deficits (61%), seizure (59%), visual disorder (37%) and impaired consciousness (29%). The multivariate analysis revealed D-dimer levels >1134 µg/L (OR=18.67, 95% CI:1.79-194.84) and impaired consciousness (OR=33.85, 95% CI: 3.14-365.45) were independent prognostic factors of a poor outcome during acute phase. Twenty-eight (68%) patients underwent a long-term interview. Only three women had multiple pregnancies (six pregnancies, two in each women), but no birth occurred from these. One patient had a relapse of CVST three years later, which had no relationship with pregnancy or puerperium.
Conclusions: CVST occurred mostly during puerperium. D-dimer levels >1134µg/L and impaired consciousness could predict poor outcomes of pregnancy-related CVST. The subsequent pregnancy rate and CVST relapse rate was low in this Chinese population.
Cerebral salt wasting in a patient with myeloproliferative neoplasm
Authors: Orlik Lea , Venzin Reto , Fehr Thomas , Hohloch Karin
Published: December 2018

Background: Cerebral salt wasting (CSW) is a rare metabolic disorder with severe hyponatremia and volume depletion usually caused by brain injury like trauma, cerebral lesion, tumor or a cerebral hematoma. The renal function is normal with excretion of very high amounts of sodium in the urine. Diagnosis is made by excluding other reasons for hyponatremia, mainly the syndrome of inappropriate antidiuretic hormone secretion (SIADH).
Case report: A 60-year-old patient was admitted to the emergency room with pain in the upper abdomen and visual disturbance two weeks after knee replacement. The patient was confused with severe hematoma at the site of the knee endoprosthesis. Laboratory values showed massive thrombocytosis, leukocytosis, anemia, severe hyponatremia and no evidence of infection. CT scan of the abdomen was inconspicuous. Head MRI showed no ischemia or bleeding, but a mild microangiopathy. A myeloproliferative neoplasm (MPN) was suspected and confirmed by bone marrow biopsy. Cerebral salt wasting syndrome was identified as the cause of severe hyponatremia most likely provoked by cerebral microcirculatory disturbance. The hematoma at the operation site was interpreted as a result of a secondary von Willebrand syndrome (vWS) due to the myeloproliferative neoplasm with massive thrombocytosis. After starting cytoreductive therapy with hydroxycarbamide, thrombocytosis and blood sodium slowly improved along with normalization of his mental condition.
Conclusion: To the best of our knowledge this is the first description of a patient with CSW most likely caused by a microcirculatory disturbance due to a massive thrombocytosis in the context of a myleopoliferative neoplasm.
Key words: Cerebral salt wasting syndrome, hyponatremia, myeloproliferative syndrome
Quality of life in patients with stroke at 1-year after discharge from inpatient rehabilitation: A multicenter study
Authors: Kuptniratsaikul Vilai , Thanakiatpinyo Thanitta , Hongsapol Chawalit
Published: December 2018

Background: Stroke is a major health problem leading to chronic disability and a negative impact on the quality of life (QoL). This study aimed to investigate QoL and its related factors 1-year after discharge from post-stroke inpatient rehabilitation.
Methods: This longitudinal study was performed among 9 rehabilitation centres. QoL of stroke patients was evaluated using the WHOQOL-BREF. Its score ranged from 26-130, with a higher score representing better QoL. Factors related to QoL were analysed using univariate and multiple linear regression.
Results: One hundred and ninety-seven patients were recruited, with a mean age of 62.3 years. The majority of patients were male (57.4%). The mean score of QoL score of patients with stroke at 1-year was significantly lower than the score at discharge period. In multiple linear regression analysis, 5 factors were associated with QoL, including having a leisure activity, modified Barthel Index at follow-up period, need caregiver, anxiety, and depression score with regression coefficient (b) of 6.29 (95%CI: 2.23, 10.35), 0.63 (95%CI: 0.07, 1.20), -7.72 (95%CI: -12.04, -3.40), -0.78 (95%CI: -1.40, -0.17), and -1.14 (95% CI: -1.72, -0.57).
Conclusion: At 1 year, patients with stroke had poorer QoL compared to discharge period. Factors strongly related to QoL included having leisure activity, no need for caregiver, and no depression. The other factor were high functional score at follow-up period and no anxiety. Further study with adequate sample size and consider physician visits to patients who fail to follow-up should be performed in order to strengthen the integrity of these findings.
Trial registration: TCTR20180531006 (Retrospectively registered). Date 31 May 2018
Keywords: Stroke, quality of life, rehabilitation, WHOQOL-BREF
The ASSIST Study - The BD Odon Device for assisted vaginal birth: a safety and feasibility study
Authors: O'Brien Stephen , Hotton Emily , Lenguerrand Erik , Wade Julia , Winter Cathy , Draycott Tim , Crofts Joanna J , Team Assist Study
Published: December 2018

Background: Assisted vaginal birth is a vital health intervention that can result in better outcomes for mothers and their babies when complications arise in the second stage of labour. Unfortunately, instruments for assisted vaginal birth (forceps and ventouse) are often not utilised in settings where there is most clinical need, resulting in maternal and neonatal morbidity and mortality which could have been prevented. The BD Odon Device is a new device for assisted vaginal birth which may be able to address this unmet need. However, before dissemination the device requires evaluation in robust clinical trials. A feasibility study to investigate the clinical impact, safety and acceptability of the BD Odon Device for assisted vaginal birth is therefore planned. This will provide further information on acceptability, recruitment and the outcome data required to design a future randomised controlled trial of the BD Odon Device versus Kiwi ventouse.
Methods: Forty women who require an assisted vaginal birth for a recognised clinical indication will have the birth assisted with the BD Odon Device. The primary outcome is successful vaginal birth completed with the BD Odon Device. Secondary clinical outcomes include maternal and neonatal outcomes, and maternal and practitioner satisfaction. Safety data will be reviewed following every birth.
Discussion: A future randomised controlled trial (RCT) of the BD Odon Device versus current standard instrument (the Kiwi ventouse) is planned. The findings of the ASSIST Study will inform the RCT design.
Trial registration: ISRCTN registration: ISRCTN10203171 (prospectively registered 27/07/2018).
Keywords: BD Odon Device, forceps, ventouse, assisted birth, birth, intrapartum research
Targeted Interventions to Prevent Chronic Low Back Pain in High Risk Patients: Development and Delivery of a Pragmatic Training Course of Psychologically Informed Physical Therapy for the TARGET Trial
Authors: Beneciuk Jason , George Steven Z. , Greco Carol , Schneider Michael , Wegener Stephen T. , Saper Robert , Delitto Anthony
Published: December 2018

Background: Low back pain (LBP) is a public health concern because it is highly prevalent and the leading cause of disability worldwide. Psychologically Informed Physical Therapy (PIPT) is secondary prevention approach that first aims to identify individuals at high risk for transitioning to chronicity and then provides tailored treatment to reduce that risk. Training models that are feasible to implement with acceptable training quality are needed to improve scalability for widespread implementation of PIPT. This manuscript describes the PIPT training program that was developed for training physical therapists providing PIPT in the TARGET Trial.
Methods: The PIPT training program was developed, tested, and modified using an iterative process. Content development consisted of stakeholder engagement, beta testing, modification of training and confirmation of final course objectives. Methods of delivery consisted of a website that included brief educational modules followed by a live 8 hour workshop that included video based mock case scenarios and case-based role playing. Attitudes, beliefs and confidence in implementing PIPT principles were assessed before and immediately after training to measure training quality and impact.
Results: Early stakeholder engagement and beta testing indicated the need for increased emphasis on experiential learning opportunities and patient-centered communication training. Booster training varied extensively across TARGET sites with involvement of ‘clinician champions’ brief follow-up sessions identified as best practice. Favorable post training changes in physical therapist attitudes and beliefs toward biopsychosocial treatment orientation and increased confidence in implementing PIPT principles were observed.
Conclusions: PIPT training for provider participation in the TARGET Trial was feasible to deliver. Course content was acceptable to physical therapists and resulted in improved beliefs and confidence in applying PIPT skills during clinical practice. Ongoing consultation and site-based continuing education were methods by which specific TARGET sites maintained or augmented PIPT skill training, however implementing ongoing training was challenging in general. Consistent with a pragmatic trial whether this training directly impacted treatment fidelity was not measured, which was a limitation to our training approach.
Measuring Clinical Uncertainty by Applying the Agreement Study Methodology to Patient Management Decisions
Authors: Fahed Robert , Darsaut Tim E. , Farzin Behzad , Chagnon Miguel , Raymond Jean
Published: December 2018

Background: Clinical dilemmas in the treatment of patients translate into disagreements in decision-making. Such disagreements can reveal clinical uncertainty that should be addressed through care research. Our goal was to explore the use of reliability study methods to measure the degree of clinical uncertainty regarding the use of rival management options.
Methods: The study design resembles an inter-/intra-observer diagnostic reliability study. A portfolio of a sufficient number of diverse individual patients sharing a similar clinical problem and covering a wide spectrum of clinical presentations can be independently submitted to a variety of clinicians who manage that problem. Clinicians are asked to choose one of the predefined management options that are involved in the clinical dilemma. Intra-rater agreement can be assessed at a later time with a second evaluation.
Results: Descriptive statistics are presented, and results analyzed using kappa statistics. Interpretation of results can be facilitated by providing examples or by translating the results into clinically meaningful summary sentences. Reporting should follow standard guidelines.
Conclusion: Measuring the uncertainty regarding management options for clinical problems may reveal disagreements and inform or facilitate the design/conduct of clinical trials to address the clinical dilemma.
The Typology of Life Trajectories Among Persons with Hearing Impairment and Mobility Disabilities
Authors: Khazova Svetlana , Adeeva Tatiana , Tikhonova Inna , Shipova Natalia
Published: December 2018

The article analyzes the sociological and psychological approaches to the understanding of the “life trajectory” phenomenon. The “life trajectory” and “way of life” notions are compared as well as categorical features which describe life trajectories were pointed out, the most important of which are: sociocultural determinism, dynamism, eventfulness, continuity, narrativity, typical nature as the evidence of the similarity between trajectories in a particular group of people within specific time and space frame. The authors have suggested a novel approach which enables to identify objective facts making up one’s life trajectory and their subjective interpretation. The empirical data allowed to recognize two variations of life trajectories that were code-named the “hypersthenic” (highly positive appraisal is prevalent) and “hyposthenic” (pessimistic appraisal of life events is prevalent) ones. It led to the conclusion about both theoretical and methodological complexity to study disabled persons’ life trajectories.
Alianza universidad empresa mejoran competencias en soldadura de estudiantes del séptimo semestre de EPIM UNDAC-Pasco-2018
Authors: Blanco Osmer
Published: December 2018

Es conocido que el desarrollo del Perú como del resto de países, depende fundamentalmente de su calidad y cantidad de ingenieros para ser una nación desarrollada. La ingeniería metalúrgica es fundamental para crear las demás tecnologías. Por ello era imperativo mejorar la formación de los futuros ingenieros de la EPIM. Teniendo conocimiento de lo alejado que se encuentra el plan de estudios de la especialidad en relación a lo que el futuro ingeniero va a ejecutar en su centro laboral, se realizó la presente investigación, que consistió en determinar Sí mejora el desarrollo de competencias en soldadura de los estudiantes del séptimo semestre de la escuela de Ingeniería Metalúrgica con la ejecución de talleres y cursos con personal de la industria minera. Se decidió invitar a profesionales que se encuentran ejerciendo su profesión en las compañías mineras de la región (VOLCAN y NEXA), para reforzar las destrezas de 20 estudiantes del séptimo semestre de la carrera de Ingeniería Metalúrgica de la UNDAC, los cuales llevan el curso de Soldadura y Mecanización de Metales. El presente artículo contempla el análisis de la generación de habilidades en riesgo crítico de seguridad de trabajos en caliente, en los estudiantes en mención. Teniendo como resultado que el 100% de estudiantes aprobaron las evaluaciones que las respectivas compañías toman a sus supervisores. Concluyendo que existe evidencia estadística que sostiene que se mejoró las competencias de los estudiantes mencionados.
Inteligencias múltiples y estilos de aprendizaje en estudiantes de psicología de un curso en modalidad de educación virtual (Multiple intelligences and learning styles in psychology students of a course in virtual education modality)
Authors: Paredes Claudia Andrea , Verney Clara Tatiana , Tolosa Laura Gisella
Published: December 2018

Se pretende describir el perfl de estudiantes basado en las Inteligencias Múltiples y los estilos de aprendizaje. El estudio se encuentra enmarcado dentro de una investigación cuantitativa, con un diseño de carácter descriptivo, en el cual se aplicaron dos cuestionarios (Cuestionario de Detección de las Inteligencias Múltiples, adaptado por Walter Mckenzie y el Diagnóstico Integral de Dominancia Cerebral (DIDC) adaptado por Omar Gardié), los cuales fueron aplicados por medio de la plataforma Google forms. Participaron 107 estudiantes de psicología inscritos en un curso de primera matrícula en modalidad de educación virtual del programa de Psicología de la UNAD con 89.7% mujeres, el promedio de edad fue de 26.72 años (DE 9.06) y rendimiento académico entre 0.02 y 4.9 siendo 5.0 el más alto. Como hipótesis nula se plantea la no existencia de diferencia estadísticamente signifcativa entre las inteligencias múltiples y los estilos de aprendizaje en los estudiantes. Los resultados sugieren que el estilo de aprendizaje predominante? según la teoría del cerebro totalde Hermann, corresponde al cuadrante B con una media de = 66. Se encontró que la inteligencia predominante fue la intrapersonal con una media de = 79.21. Finalmente, al realizar el análisis de varianzas las variables del estudio, se encontró relaciones estadísticamente signifcativas entre el Cuadrante C y la edad (p<.009), la inteligencia visoespacial con el cuadrante A F(24,82)=1.78,p<.029,Inteligencia física cenestésica con el cuadrante B F(25,81)=1.69,p<.040, Inteligencia lingüística con el promedio de califcaciones F(57,45)=1.68,p=.036.
Estrategia de evaluación para el mejoramiento continuo de cursos de un programa de Artes Visuales en modalidad virtual y a distancia: Estudio de caso (Evaluation strategy for the continuous improvement of courses of a Visual Arts program in virtual and distance modality: Case study)
Authors: Martínez Espinosa Raúl Alejandro , Martínez Santis Tatiana , Hernández Contreras Daniela
Published: December 2018

La presente investigación se desarrolló con un diseño metodológico de tipo cualitativo, especifícamente estudio de caso, con técnica de recolección de datos grupo focal en estudiantes activos y docentes del programa de artes visuales de una universidad pública de Colombia con modalidad virtual y a distancia. Su objetivo principal fue desarrollar una estrategia de evaluación del programaacadémico en artes visuales ofertado en ambientes virtuales de aprendizaje. En el año 2016, inicia el programa de artes visuales con una matrícula de 50 estudiantes activos, para el siguiente año el número se incrementa a 278. La población de estudiantes, es heterogénea, entre los 16 a los 45 añosy condiciones socio-económicas con presencia en 63 centros de educación abierta y a distancia en Colombia. Los resultados concentrados en tres categorías analíticas, siendo: expectativas frente al programa y su metodología, acompañamiento docente y nuevos recursos didácticos y pedagógicos.Su impacto se reﬂeja en los siguientes hallazgos: a. Establecimiento de un programa académico como objeto de estudio; b. Diseño de contenidos teórico-metodológicos con recursos educativos digitales pertinentes e innovadores, que propician el aprendizaje autónomo y signifcativo; c. Identifcación de expectativas y necesidades de docentes y estudiantes activos como parte del proceso de enseñanza y aprendizaje de las artes, metodologías de investigación y creación de obra; d. Implementación de una ruta metodologíca para la evaluación constante, estableciendo prácticas de gestión académicaal interior del programa caracterizadas por la calidad, toma de decisiones basadas en investigación y orientadas a la excelencia académica.
Las notificaciones por edictos a los residentes peruanos en el extranjero en los procesos judiciales de alimentos. Lima, 2016
Authors: Hermoza Calero Jessica Pilar
Published: December 2018

La presente investigación, “Las notificaciones por edictos a los residentes peruanos en el extranjero en los procesos judiciales de alimentos. Lima, 2016”, tuvo como objetivo determinar de qué manera las notificaciones por edictos a los residentes peruanos en el extranjero causa indefensión en los procesos judiciales de alimentos, Lima, 2016. La metodología es de tipo básico; el diseño, teoría fundamentada y transversal de nivel descriptivo-explicativo; el método fue inductivo, con un enfoque cualitativo; la muestra fue de cuatro abogados en derecho de familia; el proceso de recolección de datos fue una entrevista personal planteada, llegándose a las siguientes conclusiones: existe actualmente una indefensión en los procesos judiciales de alimentos a los residentes peruanos en el extranjero, en el caso que solo se desarrollan a través de las notificaciones vía exhorto, y en algunos casos no se ubican a los demandados o destinatarios.
La omisión del procurador público de proponer su pretensión reparatoria en etapa intermedia ¿Es posible continuar con la pretensión civil a pesar de que no se ha requerido un monto ni ofrecido medios probatorios?
Authors: Jiménez Jara Edgardo Salomón
Published: December 2018

La presente investigación aborda aspectos referidos a una omisión del procurador público, en su condición de actor civil, de proponer el monto de su reparación civil y ofrecer los medios probatorios, durante la etapa intermedia. Estamos ante un hecho que no debería presentarse, pero ante lo cual el derecho procesal debe tener una respuesta, al no encontrarse regulada de manera expresa en el Código Procesal Penal Peruano. Tal vez aún no es posible imaginarnos una condena sin la fijación de un monto por reparación civil, pero la norma procesal penal vigente ya determina una absolución con la fijación de un monto por concepto de reparación civil. Por ello, resulta importante establecer la relación entre el derecho procesal penal y el derecho procesal civil, fijar criterios que permitan no solo darle solución a este problema sino definir si estamos ante un desistimiento de la pretensión civil o ante otra figura procesal.
La transferencia tecnológica en el entorno empresarial cubano
Authors: Rondón Valdés Jorge , Antúnez Sánchez Alcides
Published: December 2018

El fenómeno tecnológico emerge definitivo y determinante para el desarrollo científico-técnico de cualquier país, como reto y perspectiva en el entorno empresarial. La construcción de estrategias más funcionales son garantes del avance tecnológico para la realización de su objeto social. Desde de la imposibilidad relativa de progreso científico-tecnológico endógeno, la transferencia de tecnologías deviene necesaria ante los pasos de una sociedad en vías de desarrollo. Su gradual evolución ha devenido poco pertinente, en ocasiones descontextualizada su implementación para las empresas cubanas como receptoras de paquetes tecnológicos, para fundamentar la necesariaconstrucción de un proceso que armonice las demandas y realidades. Se utilizaron como métodos de investigación: el análisis lógico e histórico jurídico, análisis-síntesis, inductivo- deductivo, exegético jurídico y de derecho comparado. Los aportes de esta investigación permiten la construcción de marcos teóricos que sustenten estrategias y procesos de transferencia tecnológica horizontales y pertinentes.
About Optimization Methods Printing Activity
Authors: Kartvelishvili V. M. , Krynetskiy D. S. , Yusupova A. S.
Published: December 2018

The article considers publication activity of academic and pedagogical workers of the university as an important criterion of the organization and its personnel work. Publication activity is an indirect presentation of results of employees' research work. The review of leading bases of academic citing of Russian authors, including international ones (Web of Scince, Scopus), as international publication activity shows the degree of science development in the Russian Federation in comparison with science in other countries. The article investigates the interrelation of subjective in-university assessment of the author's publication activity and objective positioning of the employee's works in academic community through local indicators of awarding and score rating fixed by the university, which in their turn can become a key administrative way of stimulating publication activity. The optimization task of creating a bonus plan for publications taking into account structural and budgetary constraints, as well as psychosocial aspects of the behavior of authors, was solved.
The Conceptual Model for Estimation and Opmimization of the Regional Informatization Process Development
Authors: Kadtsyna E. S.
Published: December 2018

The research aims at the development of theoretical and methodological provisions connected with developing the regional informatization process. There is a need in identifying the approach to designing and supporting information policy dealing with informatiztion development on the regional level. The article puts forward a conceptual model, which grounds the necessity of the complex approach to estimation and optimization of the process of regional informatization development. The model implies systematization and amendment of the existing theoretical and methodological provisions and approaches connected with estimation and optimization of development. With the help of methodological tools proposed within the frames of the model the complex and diversified approach to the problem of regional informatization can be possible. It includes the key components of information policy: identifying the level of information and technological potential of the regional economy development, obtaining the adequate estimation of efficiency of the current development of information and technological processes in different sectors and hierarchical levels of the regional economic system with subsequent development and substantiation of mechanisms of optimizing the information process development. Within the frames of the model the author grounds the need to extend methodological basis connected with the development of practical mechanism of optimizing the process of regional informatization development as one of the most important tools of information policy. The findings of the research can be used in the process of designing and correcting regional strategic programs of informatization development and as a material for further theoretical and applied research in the field of developing information and technological processes of regional economic systems.
Assessing Innovation Potential of the Agricultural Enterprise
Authors: Burlankov S. P. , Kuzmin S. A.
Published: December 2018

The article discusses different academic views on the assessment of innovation potential of the enterprise. Opinions of scientists in the field of management and assessment of the enterprise innovation potential served as a methodological foundation of the research. Researchers dealing with issues of innovation potential management developed qualitative and quantitative methods of potential estimation and formulated approaches to its assessment. The authors support the quantitative approach to assessment and estimation of innovation potential, therefore indicators have mainly mathematic expression. By studying methods of enterprise innovation potential estimation systematization of approaches was carried out. Different authors classified methods of estimation depending on needs of the market environment and on conceptual characteristic of the potential. The article revealed that the optimal methodology of estimation and management of innovation potential had not been formulated, thus we need approaches based on integral qualitative indicators, which can characterize the innovation potential.
Try to Remember: Interplay between Memory and Substance Use Disorder
Authors: Mohamed Rashidi Mohamed Pakri , Kumar Jaya , Yap Ernie , Mohamed Isa Naina , Sidi Hatta , Adam Raja Lope , Das Srijit
Published: December 2018

Memories associated with substance use disorders, or substance-associated cues increase the likelihood of craving and relapse during abstinence. There is a growing consensus that manipulation of synaptic plasticity may reduce the strength of substance abuse-related memories. On the biological front, there are new insights that suggest memories associated with substance use disorder may follow unique neurobiological pathways that render them more accessible to pharmacological intervention. In parallel to this, research in neurochemistry has identified several potential candidate molecules that could influence the formation and maintenance of long-term memory. Drugs that target these molecules (blebbistatin, isradipine and zeta inhibitory peptide) have shown promise at the preclinical stage. In this review, we shall provide an overview of the evolving understanding on the biochemical mechanisms involved in memory formation and expound on the premise that substance use disorder is a learning disorder.
Ultrasound-Targeted Delivery Technology: A Novel Strategy for Tumor- Targeted Therapy
Authors: Du Meng , Chen Zhiyi , Chen Yuhao , Li Yue
Published: December 2018

Background:

Ultrasound has been widely used in clinical diagnosis because it is noninvasive, inexpensive, simple, and reproducible. With the development of molecular imaging, material science, and ultrasound contrast agents, ultrasound-targeted delivery technology has emerged. The interaction of ultrasound and molecular probes can be exploited to change the structures of cells and tissues in order to promote the targeted release of therapeutic substances to local tumors. The targeted delivery of drugs, genes, and gases would not only improve the efficacy of tumor treatment but also avoid the systemic toxicity and side effects caused by antitumor treatments. This technology was recently applied in clinical trials and showed enormous potential for clinical application.

Objective:

This article briefly introduces the characteristics of the tumor microenvironment and the principle of ultrasound-targeted delivery technology. To present recent progress in this field, this review focuses on the application of ultrasound-targeted delivery technology in tumor-targeted therapy, including drug delivery, gene transfection, and gas treatment.

Results:

The results of this study show that ultrasound-targeted delivery technology is a promising therapeutic strategy for tumor treatment.

Conclusion:

Ultrasound-targeted delivery technology shows promise with regard to cancer treatment.
Screening of Extremophile Microalgae Isolated from High Background Radiation Areas as Source of Bioactive Materials
Authors: Heidari Fatemeh , Shariatmadari Zeinab , Riahi Hossein
Published: December 2018

Background:

Microalgae are the source of various compounds with high potentials for being
used in different industries. The production of such compounds can be raised under extreme conditions.
In the present study, four cyanobacteria and one coccoid green alga were examined which were isolated
from hot springs in high background radiation areas in Ramsar, a city in the north of Iran.

Methods:

Cadmium adsorption from aqueous solution, response towards cadmium stress, antioxidant
activity, total phenolic compound and drought tolerance were investigated in these microalgae.

Results:

The results showed that these extremophile microalgae contain valuable biological compounds
which can be useful in remediation of heavy metals from contaminated water and soils and pharmaceutical
applications. The unicellular cyanobacterium, Chroococidiopsis thermalis IBRC-M50002, was the
best strain with the highest biological activity in various testes such as cadmium adsorption (225 mg
g-1), cadmium tolerance stress (100 mg ml-1), antioxidant activity (IC50= 18 μg mg-1) and total phenol content
(100 μg ml-1). The coccoid green algae Grasiella emersonii IBRC-M50001, also exhibited significant
antioxidant activity (IC50=10 μg mg-1) and total phenol compound (116 μg ml-1), but its cadmium adsorption,
tolerance at cadmium stress and desiccation were lower than Chroococidiopsis thermalis.

Conclusion:

HBRAs microalgae, isolated from extreme conditions, are useful microorganisms for the
production of bioactive substances and natural antioxidants. In other words, they exhibited high capacity
to be used in pharmaceutical, industrial and commercial applications.
Recent Trends in Chiral Separation-A Collective Paradigm of Selected Chiral Impurities
Authors: Raikar Prachi , Bannimath Gurupadayya
Published: December 2018

Chiral separation plays a very important role in the modern pharmaceutical analysis and will
continue in upcoming years. Separation and identification of chiral impurities are indispensable. According
to ICH guidelines, only the active enantiomer of the drug has to be marketed, so there is a focus
on separation of the inactive enantiomer which acts as a chiral impurity. The impurities present in the
enantiomers also pose various toxic adverse effects on bioavailability and efficacy, hence the need to
separate these impurities will forever be trending. This review primarily focuses on the separation techniques
like Capillary Electrophoresis (CE), High-Performance Liquid Chromatography (HPLC), Gas
Chromatography (GC), and Supercritical Fluid Chromatography (SFC) followed by the year-wise trend
in the separation of selected chiral impurities. In the coming years, researchers should work on using
ultra-fast, selective, and sensitive methods for the effective separation of chiral impurities.
Evaluation of Toll-like Receptor 2 Gene Expression in Rheumatoid Arthritis and Correlation with the Disease Activity
Authors: Nasser Mai , Hazem Noha M. , Atwa Amany , Baiomy Amina
Published: December 2018

Background:

Rheumatoid Arthritis (RA) is an autoimmune, chronic, and systematic
disease. It affects joints and bones. The exact etiology of RA is still unclear. Varied genetic
and environmental factors have been associated with the increased risk for RA. Overactivation
of Toll-Like Receptors (TLRs) could initiate the development of autoimmune diseases
including RA.

Objective:

The aim of the study was to evaluate TLR2 gene expression in rheumatoid arthritis
patients and investigate its correlation with the disease activity.

Materials and Methods:

This study included 60 patients and 20 healthy individuals. The patients
were diagnosed with RA according to the 2010 American College of Rheumatology/
European League Against Rheumatism criteria (ACR/EULAR). All included subjects
did not have any joint disorders and /or autoimmune diseases. RA disease activity was determined
by the disease activity score of 28 joints. Whole blood was collected from all participants.
Total RNA extraction was done. TLR2 mRNA expression was assessed by reverse
transcription-PCR (RT-PCR).

Results:

TLR2 mRNA expression was found to be significantly higher in RA patients compared
to healthy controls. Also, a strong positive correlation was found between TLR2 expression
level and the disease activity score. A non significant positive correlation was found
between TLR2 expression and serum Rheumatoid Factor (RF) level.

Conclusion:

TLR2 pathway may have an important role in RA pathogenesis and could be a
new biomarker for diagnosis and monitoring disease activity.
Feature Selection for Histopathological Image Classification using levy Flight Salp Swarm Optimizer
Authors: Rachapudi Venubabu , Devi Golagani Lavanya
Published: December 2018

Background:

An efficient feature selection method for Histopathological image classification plays an important role to eliminate irrelevant and redundant features. Therefore, this paper proposes a new levy flight salp swarm optimizer based feature selection method.

Methods:

The proposed levy flight salp swarm optimizer based feature selection method uses the levy flight steps for each follower salp to deviate them from local optima. The best solution returns the relevant and non-redundant features, which are fed to different classifiers for efficient and robust image classification.

Results:

The efficiency of the proposed levy flight salp swarm optimizer has been verified on 20 benchmark functions. The anticipated scheme beats the other considered meta-heuristic approaches. Furthermore, the anticipated feature selection method has shown better reduction in SURF features than other considered methods and performed well for histopathological image classification.

Conclusion:

This paper proposes an efficient levy flight salp Swarm Optimizer by modifying the step size of follower salp. The proposed modification reduces the chances of sticking into local optima. Furthermore, levy flight salp Swarm Optimizer has been utilized in the selection of optimum features from SURF features for the histopathological image classification. The simulation results validate that proposed method provides optimal values and high classification performance in comparison to other methods.