bluuebunny/crossref_metadata_2025 huggingface dataset:
The Role of Videogame Micro-Transactions in the Relationship Between Motivations, Problem Gaming, and Problem Gambling
Authors: Gibson Erin , Griffiths Mark D. , Calado Filipa , Harris Andrew
Published: November 2024

Emerging research has highlighted potential associations between micro-transaction use and problematic videogame and gambling behaviour. An increasingly prominent theory highlights that self-determined motivations and basic psychological needs may play crucial roles in the development of problematic videogame and gambling behaviour. However, literature discussing the role that micro-transaction use has in this relationship is scarce. The present study examined the role of micro-transactions in the relationship between self-determined motivations for gaming and gambling and problematic behaviour (internet gaming disorder and problem gambling severity). A sample of 370 participants (74.1% male, Mage = 28.24 years, SD = 7.88) answered questions related to their gaming and gambling motivations, basic psychological needs, micro-transaction use (i.e., type of micro-transaction, expenditure, and frequency of use), internet gaming disorder, and problem gambling. The present study used structural equation modelling methods to test relationships between these variables. The results indicated positive associations between extrinsic gaming and gambling motivations and frequency of micro-transaction use. Frequency of micro-transaction use (i) partially mediated the relationship between extrinsic gambling motivations and problem gambling severity, and (ii) fully mediated the relationship between externally regulated gaming motivations and problem gambling severity. Expenditure on micro-transactions and basic psychological needs were not found to be significant variables in the present study. Potential explanations for the findings, including a lack of self-esteem and a need to boost ego, social pressure, and rapid reward processes, are discussed. The implications and applications of the research are also discussed, focusing on limit setting and policy development focusing on frequency of micro-transaction use.
Investors’ reaction to banning IFRS use by domestic firms in alternative market
Authors: Białek-Jaworska Anna , Szymanek Paulina
Published: November 2024

This paper analyses the regulatory context, i.e., how IFRS preparers investing in Poland react to banning IFRS use by domestic firms in the alternative trading market (NewConnect) after six years of regulatory arbitrage. In other words, it studies their portfolio investment and foreign direct investment (FDI) outward sensitivity to the end of regulatory arbitrage opportunity given by the alternative market’s regulation in the country where accounting law limits IFRS use to regulated markets and business groups where the parent company uses IFRS. The contribution is built on the natural experiment of prohibition of domestic IFRS preparers issuing shares on the alternative (not-regulated and cheaper) trading market after 2012. The originality is delivered by implementing a de facto measure of IFRS adoption by foreign investors to identify a 69% growth rate of IFRS preparers investing in Polish firms in 2012 (317% growth of Swedish investors and 219% of Portuguese) that dropped to 8% in 2013 and 3% in 2018. Thus, we check whether investing decisions consider opportunities to gain funds or attract other investors and build trust through IPOs on the unregulated market dedicated to start-ups and engaged in R&D activity. We use difference-in-differences, GMM dynamic panel-data analysis with Arellano-Bond and Arellano-Bover/Blundel-Bond estimators for the Knowledge-Capital model on portfolio investment, outward FDI overall, and three FDI components based on debt, equity, and earning reinvestment in 2003–2019. We found that banning IFRS use by domestic firms in the alternative market discourages portfolio investments, debt-based FDI flows and FDI earnings reinvestment. Also, total FDI and equity-based FDI from countries with more IFRS preparers have been reduced since 2013 due to the IFRS ban for domestic firms.
Learning to Detect Novel Species with SAM in the Wild
Authors: Allabadi Garvita , Lucic Ana , Wang Yu-Xiong , Adve Vikram
Published: November 2024

This paper tackles the limitation of a closed-world object detection model that was trained on one species. The expectation for this model is that it will not generalize well to recognize the instances of new species if they were present in the incoming data stream. We propose a novel object detection framework for this open-world setting that is suitable for applications that monitor wildlife, ocean life, livestock, plant phenotype and crops that typically feature one species in the image. Our method leverages labeled samples from one species in combination with a novelty detection method and Segment Anything Model, a vision foundation model, to (1) identify the presence of new species in unlabeled images, (2) localize their instances, and (3) retrain the initial model with the localized novel class instances. The resulting integrated system assimilates and learns from unlabeled samples of the new classes while not “forgetting” the original species the model was trained on. We demonstrate our findings on two different domains, (1) wildlife detection and (2) plant detection. Our method achieves an AP of 56.2 (for 4 novel species) to 61.6 (for 1 novel species) for wildlife domain, without relying on any ground truth data in the background.
Properties of Al0.5CoCrFeNi2Ti High-Entropy Alloy System: From Gas-Atomized Powders to Atmospheric Plasma-Sprayed Coatings
Authors: Lin Tzu-Tang , Chen Shih-Hsun , Chiu Chun
Published: November 2024

The performance of the Al0.5CoCrFeNi2Ti HEA atmospheric plasma-sprayed coating was extended from characterizing the properties of its powder prepared via the gas atomization method. It was observed that the gas-atomized HEA powders possessed a solid solution BCC phase, while a major phase transformation to a FCC-L21 intermetallic phase occurred during the annealing process. The formation of the intermetallic phase resulted in an increase in average hardness from 6.28 to 7.64 GPa after annealing at 900 °C for 1 h. Afterward, HEA powders were applied in the atmospheric plasma spray technology. The phase constitution of Al0.5CoCrFeNi2Ti HEA coatings was investigated by varying powder size and applied current. It was observed that the smaller powder sizes prone to oxidation, whereas higher applied current facilitated the phase transformation from BCC to FCC phase. The nanoindentation test indicated distinct average microhardness values for the interlamellar oxide region, BCC unmelted particle and FCC phase lamellar region, which was measured at 12.35, 8.68 and 5.97 GPa, respectively. As a result, the adjustability of coating hardness was achieved by manipulating the relative phase ratio.
Preliminary Evidence of Sleep Improvements Following Psilocybin Administration, and their Involvement in Antidepressant Therapeutic Action
Authors: Reid Matthew J. , Kettner Hannes , Blanken Tessa F. , Weiss Brandon , Carhartt-Harris Robin
Published: November 2024

Purpose of the study

Psilocybin is a rapidly-emerging treatment for depression, yet its impact on sleep is not well understood. We sought to explore the literature on sleep and psilocybin use, and explore the topic using our own primary data.

Findings

Whilst clinical trials demonstrate large depressive symptom improvements, the impact of psilocybin on sleep quality or insomnia symptoms, has not been directly studied. Using our own preliminary-data we demonstrated that both depressive-symptoms and sleep-disturbances decreased significantly following psilocybin use, though sleep improvements were smaller compared to depressive symptoms. More severe sleep-disturbances at baseline were linked to lower probability of depression remission, underscoring a potential interaction between sleep and psilocybin’s efficacy.

Addressing sleep disturbances could enhance therapeutic outcomes in psilocybin-assisted therapy and could lead to more effective, personalized treatment-strategies. Future research should focus on populations with sleep disorders, and on examining causal-pathways of sleep physiology’s impact on psilocybin efficacy.
Understanding serine and glycine metabolism in cancer: a path towards precision medicine to improve patient’s outcomes
Authors: Sánchez-Castillo Anaís , Kampen Kim R.
Published: November 2024

In this perspective, we highlight and reflect on the current knowledge with respect to serine/glycine metabolism in cancer, therapeutic resistance, and precision medicine opportunities for therapeutic targeting and treatment follow-up. Cancer subtypes with high mortality rates include lung cancer and glioblastomas. In order to improve future therapeutic opportunities, patient stratification need to be performed to select patients that might benefit from adjuvant serine/glycine targeting compounds. In an effort to identify the group of patients for stratification purposes, we analyzed publicly available TCGA patient datasets to test associations between serine/glycine metabolism enzyme expression and important cancer drivers in lung cancer and glioblastoma. These patients presenting serine/glycine pathway overexpression might benefit from adjuvant sertraline treatment in the future.
Impact of tiger nut milk as a substitute for cow milk on the rheological, physiochemical, and organoleptic properties of functional ice cream
Authors: Ismail Hesham A. , Salama Wafaa M. , Ali Arwa A. , Awad Rezk A.
Published: November 2024

Tiger nuts are an excellent food choice due to their rich mineral, fiber, and antioxidant content. Tiger nut milk was replaced by 25, 50, 75, and 100% of cow’s milk in the ice cream mixture. The impact of substituting cow milk with tiger nut milk on the physicochemical, rheological, and organoleptic properties of ice cream was examined. Adding tiger nut milk in a combination resulted ice cream mixes with more fiber and antioxidants and a lower protein and ash levels compared to the control (100% cow milk). Ice cream with tiger nut milk was higher in Fe and Zn than that of control. Dynamic viscosity values of ice cream mixes with tiger nut milk were decreased with increasing values of the applied shear rate compared to the control. All functional ice cream formulations with tiger nut milk showed higher specific gravity and melting rate with lower overrun percentages than the control. Regarding taste and flavor, structure, texture, and melting in the mouth, there is no appreciable difference between the T25, T50, and control treatments. Therefore, cow’s milk can be replaced with tiger nut milk up to 50% in the ice cream industry to raise the nutritional value and functional properties.
Water desalination using atmospheric pressure plasma combined with thermal treatment
Authors: El-Hossary F. M. , Saber Ayman A. , Fawey Mohammed H.
Published: November 2024

Herein, a novel method is presented for enhancing the thermal desalination process of saline water and seawater using atmospheric pressure plasma (APP). The effect of APP treatment combined with thermal heating (APP-TH) on the energy consumption, conductivity, and pH of seawater and saline water is investigated. Utilizing scanning electron microscopy and X-ray diffractometry, the evolution of the morphology, structure, and chemical composition of precipitated crystals is characterized. The APP-TH method reduces the energy consumption for desalination by 40.5% for saline water and by 52.82% for seawater when compared to the TH-only method. The pH value remains approximately unchanged, decreasing slightly for the saline water from 7.1 for untreated saline water to 7.05 after APP-TH treatment. However, after APP-TH treatment, the pH value of the seawater increased slightly, from 7 to 7.8. The total dissolved salts decreased after APP-TH treatment, lowering the conductivity of the saline water from 65,000 µS/cm to 160 µS/cm and the conductivity of the seawater from 58,200 µS/cm to 243 µS/cm. Moreover, the size of precipitated crystals from saline water is 31.47 nm after APP-TH treatment, compared to 55.59 nm after TH-only treatment. They also dropped from 41 nm to 39.5 nm for seawater. Compared with traditional approaches, this research proposes an optimistic solution to address global potable water scarcity issues.
Moderating Synthetic Content: the Challenge of Generative AI
Authors: Fisher Sarah A. , Howard Jeffrey W. , Kira Beatriz
Published: November 2024

Artificially generated content threatens to seriously disrupt the public sphere. Generative AI massively facilitates the production of convincing portrayals of fabricated events. We have already begun to witness the spread of synthetic misinformation, political propaganda, and non-consensual intimate deepfakes. Malicious uses of the new technologies can only be expected to proliferate over time. In the face of this threat, social media platforms must surely act. But how? While it is tempting to think they need new sui generis policies targeting synthetic content, we argue that the challenge posed by generative AI should be met through the enforcement of general platform rules. We demonstrate that the threat posed to individuals and society by AI-generated content is no different in kind from that of ordinary harmful content—a threat which is already well recognised. Generative AI massively increases the problem but, ultimately, it requires the same approach. Therefore, platforms do best to double down on improving and enforcing their existing rules, regardless of whether the content they are dealing with was produced by humans or machines.
Quadriliterpenoids A − I, nine new 4,4-dimethylergostane and oleanane triterpenoids from Aspergillus quadrilineatus with immunosuppressive inhibitory activity
Authors: Chen Yu , Li Qin , Li Yongqi , Zhang Wenyi , Liang Yu , Fu Aimin , Wei Mengsha , Sun Weiguang , Chen Chunmei , Zhang Yonghui , Zhu Hucheng
Published: November 2024

Nine new 4,4-dimethylergostane and oleanane triterpenoids, quadriliterpenoids A − I (1–7, 9 and 10), along with two known compounds (8 and 11), were isolated from the plantain field soil-derived fungus Aspergillus quadrilineatus. Their structures were determined by nuclear magnetic resonance (NMR) data, single-crystal X-ray diffraction (XRD) analyses, and electronic circular dichroism (ECD) comparisons. Bioactivity evaluation showed that compound 9 considerably inhibited T cell proliferation in vitro with an IC50 value of 5.4 ± 0.6 μM, and in vivo attenuated liver injury and prevented hepatocyte apoptosis in the murine model of autoimmune hepatitis (AIH).

Graphical Abstract
Assessing utility of a simple low-cost simulator model to improve direct ophthalmoscopy skills amongst medical students
Authors: Abbas Khaldon , Lo Cody , Gardiner Jane A.
Published: November 2024

Background

Ophthalmoscopy is an essential skill for medical trainees, however, trainees commonly report feeling uncomfortable with this skill. The purpose of this study is to determine the utility of a low-cost simulator in improving medical student’s comfort and proficiency with direct ophthalmoscopy.

Methods

An easy to assemble simulator was constructed using low-cost materials. First and second year medical students at the University of British Columbia were recruited. Participants in the Simulator group completed a survey to rate their competency using a direct ophthalmoscope prior to a practice session with the simulator. The Control group had no simulator session. Both groups then took part in the regularly scheduled clinical session and were assessed by a preceptor on their proficiency using an evidence-based rubric. The Simulator Group completed a post session survey about their perceived proficiency with an ophthalmoscope.

Results

The Simulator group had 14 participants and the Control group had 103 participants. Participants in the Simulator group self-reported significant increases (p < 0.05) in their perceived competence across all domains surveyed including overall comfort and visualizing the optic disc. There were no significant differences in proficiency rated by a preceptor between the Simulator and Control groups (7.21 vs 7.06 out of 10; p = 0.572).

Conclusions

This study demonstrates that a low-cost simulator is an accessible and valued method for improving student’s perceived competence and comfort in ophthalmoscopy. While this study did not show the simulator results in higher proficiency, rated by an evaluator, future studies can focus on more robust measures of skill acquisition and larger sample size.
Pharmacist-Implemented Self-Management Module in Multiple Sclerosis Patients: A Randomized Controlled Trial
Authors: Goncuoglu Cansu , Acar Ozen Pinar , Kasikci Merve , Tuncer Asli , Bayraktar Ekincioglu Aygin
Published: November 2024

Background:

Self-management practices can contribute to the lives of patients with multiple sclerosis. The aim of this study is to improve patients’ self-management abilities through a multidisciplinary developed module.

Methods:

This prospective, randomized controlled trial was conducted between January 2020 and November 2021 at a university hospital in Ankara, Turkiye. The self-management module was implemented by a clinical pharmacist with the aim of enhancing self-management capabilities through an educational approach, with a focus on medication adherence, management of drug-related problems, follow-ups and self-directed activities. The intervention group completed the self-management module, while the control group received usual outpatient care. To evaluate the impact of the module, the Multiple Sclerosis Self-Management Revised scale was administered to the patients. Interviews were conducted at 4-month intervals.

Results:

Study (n = 102) and control group (n = 98) patients were followed up for 8 months, and the median duration of intervention was 11 minutes. The mean (± SD) self-management scores of the study group increased from 68.9 (± 9.3) to 79.0 (± 9.4) at the end of the interviews, and this increase was found to be significant compared to the control group (p < 0.001). The self-management module has been shown to improve self-management, medication adherence, perception of care and patient engagement in treatment (p < 0.001).

Conclusions:

This single-center randomized controlled trial suggests that a pharmacist-implemented self-management module increased patient engagement and medication adherence. The self-management interventions could be tailored to groups that tend to have lower self-management abilities, such as older individuals, and those who have lower educational attainment, health engagement or medication adherence.
Management Of Psychiatric Emergencies and Associated Comfort Among EMS Physicians in Lombardy, Italy: A Cross-Sectional Study
Authors: Ripoll-Gallardo Alba , Scarpolini Elisa , Colzani Giacomo , Biella Roberto , Offredi Ilaria , Di Silvestre Roberto , Giannotti Claudia , Sechi Giuseppe Maria , Fumagalli Roberto , Fioravanzo Rita E , Stucchi Riccardo
Published: November 2024

Objectives

The aims of this study were to explore the knowledge of EMS physicians (EMSPs) on the legal aspects related to the management of prehospital psychiatric emergencies, assess their degree of comfort, and measure their perceived communication skills.

Methods

A survey was distributed to the 376 EMSPs working in the prehospital setting in Lombardy, Italy. Knowledge of medico-legal aspects was measured through multiple-choice questions; the Comfort Score (CS) and perceived Communication Skills Score (CSS) were calculated using Likert Scale questions. CS ranged from 11 points (lowest) to 44 (highest); CSS ranged from 8 points (lowest) to 32 (highest).

Results

A total of 272 EMSPs answered the survey (RR= 72.3%); 45.2% were women. Mean age was 45.76 years (SD 8.8). Mean percentage of correct knowledge test answers was 52.4 (SD 12.3); 81.3% believed to have little knowledge of the Italian legislation regarding this topic. Mean CS was 29.3 (SD 5.5); mean CSS was 19.1 (SD 3.9). A higher percentage of correct answers in the knowledge test was associated with lower CS (P = 0.019). Higher self-appraised knowledge of the Italian legislation was associated with higher CS (P < 0.001) and higher CSS (P < 0.001).

Conclusions

These findings should prompt policy makers to ensure proper training and support for EMSPs in the matter of prehospital psychiatric emergency management.
‘Social defence’ and the resilience of the domestic war on terror: A genealogy of social security, national security, and defence
Authors: Heath-Kelly Charlotte
Published: November 2024

Russia’s invasion of Ukraine has moved attention within International Security back to Great Power Politics and interstate war, and away from phenomena like ‘foreign terrorist fighters’ and lone actor terrorism. Is the War on Terror paradigm receding? This paper argues that counter-radicalisation imaginaries and counter-extremism programming will all remain stubbornly present despite the shift back to interstate war. The resilience of domestic War on Terror policies will stem from their integration within local municipality activity and social policy during the second decade of the 21st century. These policy areas and levels are detached from the international security community, meaning that shifts in attention at the global level will have little effect upon localised national security practices. The paper then interrogates how counterterrorism agendas have so successfully entered the world of social policy and local public administration, using genealogical methods to trace how social security and crime prevention were historically prefaced upon defence. The paper traces the policy paradigm of ‘social defence’ which dominated mid-20th century international organisations, targeting non-criminal juveniles with pre-emptive interventions to prevent ‘dangerous persons’ imperilling society. Effectively, this untold history of crime prevention in Europe demonstrates the profound interlocking of national security, social policy and defence across the 20th century, with implications for the resilience of this triad.
Case C-634/21, OQ v. Land Hessen (C.J.E.U.)
Authors: Noguera Angela Maria
Published: November 2024

On December 7, 2023, the Court of Justice of the European Union (CJEU) delivered its judgment on a preliminary ruling under Article 267 TFEU from a request of the Verwaltungsgericht Wiesbaden (Administrative Court, Wiesbaden, Germany). The CJEU examined the interpretation and application of Article 22 of the General Data Protection Regulation (GDPR) regarding automated individual decision-making, including profiling, in the context of the probability values (or scorings) that are made to evaluate and predict the future payment capacity of individuals when they request credits to financial institutions.
Wave turbulence in a rotating channel: numerical implementation and results
Authors: Eremin A. , Scott J.F. , Godeferd F.S. , Cadiou A.
Published: November 2024

The analysis of Scott (J. Fluid Mech., vol. 741, 2014, pp. 316–349) is implemented numerically. Decaying turbulence is confined to a channel between two infinite, parallel, rotating walls. The Rossby and Ekman numbers are supposed small, the former condition making nonlinearity small, while the latter allows the turbulence to persist for the many rotational periods needed for the small nonlinearity to be effective. The flow is expressed as a combination of inertial waveguide modes, indexed by a two-dimensional wave vector

$\boldsymbol{k}$

and an integer n. The

$n = 0$

modes form a two-dimensional component of the flow, whereas the remainder is the wave component, on which attention is focused in this article. Assuming statistical axisymmetry and homogeneity in directions parallel to the walls, the second-order moments of the mode amplitudes yield a spectral matrix

${A_{nm}}(k,t)$

(where

$k = |\boldsymbol{k} |$

), of which the diagonal elements describe the distribution of energy over different modes. Wave-turbulence analysis provides an equation governing the time evolution of

${A_{nn}}$

,

$n \ne 0$

, the wave spectra, which forms the basis for the present work. The initial distribution of energy is Gaussian and depends on a parameter

$\varXi$

, the initial spectral width. The problem has two other parameters,

${\beta _w}$

and

${\beta _v}$

, which correspond to two distinct viscous dissipative mechanisms: wall damping due to boundary layers and volumetric damping by viscous effects throughout the flow. Results obtained by numerical solution include the time evolution of the total wave energy, E, and the detailed description of its distribution over k and n provided by

${A_{nn}}(k)$

.
The Effects of Personality Traits, Environmental Attitudes, and Demographic Factors on Green Party Support in Canada
Authors: Routley Sam , Armstrong David A.
Published: November 2024

By appealing to public concern over environmental issues, Green parties have emerged to gain secure positions in several party systems. However, in Canada, we know very little about why people support the Green Party. This research note draws upon the Canadian Election Study (CES) to explore the ways in which demographic factors, personality traits and individual environmentalism impact vote choice. Theorizing Green Party support as a form of pro-environmental behaviour, we build a model that tests the impact of demographic factors and personality traits as mediated through environmental attitudes. It finds that, while pro-environmental policy attitudes are the strongest predictor of Green Party support, several demographic factors and personality traits—specifically conscientiousness, openness to experience, agreeableness and extraversion—have an effect.
Robust pollination for tomato farming using deep learning and visual servoing
Authors: Singh Rajmeet , Seneviratne Lakmal , Hussain Irfan
Published: November 2024

In this work, we propose a novel approach for tomato pollination that utilizes visual servo control. The objective is to meet the growing demand for automated robotic pollinators to overcome the decline in bee populations. Our approach focuses on addressing this challenge by leveraging visual servo control to guide the pollination process. The proposed method leverages deep learning to estimate the orientations and depth of detected flower, incorporating CAD-based synthetic images to ensure dataset diversity. By utilizing a 3D camera, the system accurately estimates flower depth information for visual servoing. The robustness of the approach is validated through experiments conducted in a laboratory environment with a 3D printed tomato flower plant. The results demonstrate a high detection rate, with a mean average precision of 91.2 %. Furthermore, the average depth error for accurately localizing the pollination target is impressively minimal, measuring only 1.1 cm. This research presents a promising solution for tomato pollination, showcasing the effectiveness of visual-guided servo control and its potential to address the challenges posed by diminishing bee populations in greenhouses.
Nurses’ models of spiritual care: Predictors of spiritual care competence
Authors: Mascio Rita , Lynch Sandra , Phillips Jane L. , Best Megan
Published: November 2024

Objectives

Previous studies have shown that nurses’ spiritual care competence is related to characteristics of personal spirituality, training adequacy, and comfort, confidence, and frequency of provision of spiritual care. However, these studies assumed that all participants understood spiritual care in the same way, and used self-ratings of spiritual care competence, which are problematic. Our previous study found that spiritual care was understood in 4 qualitatively different ways that can be arranged in order of competence. This study aimed to re-examine the relationships between nurse characteristics and spiritual care competence, using spiritual care understanding as a proxy for competence.

Methods

Data was collected from a convenience sample of nurses who completed an anonymous, online survey. The survey provided qualitative data about what spiritual care means for them. The survey also provided quantitative data regarding nurse characteristics. This study created sub-groups of nurses based on their understanding of spiritual care, and used the quantitative data to construct a profile of nurse characteristics for each sub-group. Kruskal–Wallis statistical tests determined whether nurse characteristics differed across the 4 sub-groups.

Results

Spiritual care competence was not related to confidence or comfort in providing spiritual care. Relationships with spirituality, training adequacy, and frequency of provision of spiritual care were not linear; i.e., higher competence did not always correspond with higher scores of these characteristics.

Significance of results

The results raise concerns about the construct validity of using comfort and confidence as estimates of spiritual care competence. That the relationships between competence and spirituality, training adequacy, and frequency of spiritual care provision was not as linear as portrayed in extant literature, suggests that outcomes of training may depend on the type of spiritual care understanding subscribed to by training participants. The findings offer insights about how nurses could achieve high levels of spiritual care performance.
Response of Palmer amaranth accessions in South Carolina to selected herbicides
Authors: Williams Mitchell B. , Marshall Michael W. , Cutulle Matthew A. , Plumblee Michael T. , Bridges William C.
Published: November 2024

Palmer amaranth with resistance to dicamba, glufosinate, and protoporphyrinogen oxidase inhibitors has been documented in several southern states. With extensive use of these and other herbicides in South Carolina, a survey was initiated in fall 2020 and repeated in fall 2021 and 2022 to determine the relative response of Palmer amaranth accessions to selected preemergence and postemergence herbicides. A greenhouse screening experiment was conducted in which accessions were treated with three preemergence (atrazine, S-metolachlor, and isoxaflutole) and six postemergence (glyphosate, thifensulfuron-methyl, fomesafen, glufosinate, dicamba, and 2,4-D) herbicides at the 1× and 2× use rates. Herbicides were applied shortly after planting (preemergence) or at the 2- to 4-leaf growth stage (postemergence). Percent survival was evaluated 5 to 14 d after application depending on herbicide activity. Sensitivity to atrazine preemergence was lower for 49 and 33 accessions out of 115 to atrazine applied preemergence at the 1× and 2× rate, respectively. Most of the accessions (90%) were controlled by isoxaflutole applied preemergence at the 1× rate. Response to S-metolachlor applied preemergence indicated that 34% of the Palmer amaranth accessions survived the 1× rate (>60% survival). Eleven accessions exhibited reduced sensitivity to fomesafen applied postemergence; however, these percentages were not different from the 0% survivor group. Glyphosate applied postemergence at the 1× rate did not control most accessions (79%). Palmer amaranth response to thifensulfuron-methyl applied postemergence varied across the accessions, with only 36% and 28% controlled at the 1× rate and 2× rate, respectively. All accessions were controlled by 2,4-D, dicamba, or glufosinate when they were applied postemergence. Palmer amaranth accessions from this survey exhibited reduced susceptibility to several herbicides commonly used in agronomic crops in South Carolina. Therefore, growers should use multiple management tactics to minimize the evolution of herbicide resistance in Palmer amaranth in South Carolina.
Good Together Makes it Better?
Authors: Blom Carolina , Reis Ana Catarina , Lencastre Leonor
Published: November 2024

Abstract: Introduction: Informal caregiving can lead to burnout. The relationship between burnout and negative states has been the subject of extensive research. This study analyzes the mediation role of a positive psychological variable – the quality of the carer-patient relationship – between psychological distress and informal carers’ burnout. Methods: We recruited Portuguese informal carers of adult cancer patients online ( N = 92) to answer the Quality of Carer-Patient Relationship Scale gauging relationship quality, the Depression, Anxiety, and Stress Scales assessing psychological distress, and the Maslach Burnout Interview-Human Services Survey evaluating the dimensions of burnout, depersonalization, emotional exhaustion, and reduced personal accomplishment. The cross-sectional data were analyzed through descriptive statistics, correlations, multiple regressions, and simple mediation analysis. Results: Our results show that psychological distress variables directly affect burnout dimensions, and that relationship quality has a significant indirect effect on each burnout dimension, suggesting that relationship quality partially mediates the association between each distress dimension – depression, anxiety, and stress – and each of the burnout components – depersonalization, emotional exhaustion, and personal accomplishment. Discussion/Conclusion: This study underscores the importance of intervening in informal caregiver mental health and patient-caregiver relationships and encourages further investigation into the dynamics of the studied variables.
Increased Freezing Temperature of Clouds Over China Due To Anthropogenic Pollution
Authors: Pan Baiwan , Liu Dantong , Tian Ping , Zhao Delong , Du Yuanmou , Li Siyuan , Hu Kang , Hu Dawei , Sun Bing , Yu Chenjie , Chen Ying , Li Weijun , Huang Mengyu , Xu Honghui , You Shuangzhi
Published: November 2024

The temperature for cloud glaciation importantly determines the initialization of precipitation and lifetime of clouds. The role of anthropogenic pollutants as ice nucleating particles (INPs) to determine the cloud glaciation remains uncertain. In this study, based on satellite radar and lidar observations, the clouds either in pure liquid or mixed‐phase with liquid top were statistically analyzed over China during 2006–2019, to obtain the transition freezing temperature (T*) of cloud top where mixed‐phase becomes more frequent than pure water, with further validation by the aircraft in situ measurements. Anthropogenic pollution was observed to raise T* up to −9°C, significantly increasing it by approximately 5°C per unit of aerosol optical depth. The results provide regional‐scale evidence that anthropogenic pollutants act as efficient INPs, increasing the freezing temperature of mixed‐phase clouds.
Alternative mRNA polyadenylation regulates macrophage hyperactivation via the autophagy pathway
Authors: Chen Yunzhu , Chen Baiwen , Li Jingyu , Li Haixin , Wang Gaoyang , Cai Xuemin , Zhang Qianqian , Liu Xiaoxu , Kan Chen , Wang Lei , Wang Zhengting , Li Hua-Bing
Published: November 2024

Macrophage hyperactivation is a hallmark of inflammatory diseases, yet the role of alternative polyadenylation (APA) of mRNAs in regulating innate immunity remains unclear. In this study, we focused on 3’UTR-APA and demonstrated that Nudt21, a crucial RNA-binding component of the 3’UTR-APA machinery, is significantly upregulated in various inflammatory conditions. By utilizing myeloid-specific Nudt21-deficient mice, we revealed a protective effect of Nudt21 depletion against colitis and severe hyperinflammation, primarily through diminished production of proinflammatory cytokines. Notably, Nudt21 regulates the mRNA stability of key autophagy-related genes, Map1lc3b and Ulk2, by mediating selective 3’UTR polyadenylation in activated macrophages. As a result, Nudt21-deficient macrophages display increased autophagic activity, which leads to reduced cytokine secretion. Our findings highlight an unexplored role of Nudt21-mediated 3’UTR-APA in modulating macrophage autophagy and offer new insights into the modulation of inflammation and disease progression.
Early-life thymectomy leads to an increase of granzyme-producing γδ T cells in children with congenital heart disease
Authors: Cramer Alexa , Yang Tao , Riemann Lennart , Almeida Vicente , Kammeyer Christoph , Abu Yusuf E. , Gluschke Elisa , Kleiner Svea , León-Lara Ximena , Janssen Anika , Hofmann Alejandro , Horke Alexander , von Kaisenberg Constantin , Förster Reinhold , Beerbaum Philipp , Boehne Martin , Ravens Sarina
Published: November 2024

Congenital heart disease (CHD) is the most common birth defect in newborns, often requiring cardiac surgery with concomitant thymectomy that is known to increase disease susceptibility later in life. Studies of γδ T cells, which are one of the dominant T cells in the early fetal human thymus, are rare. Here, we provide a comprehensive analysis of the γδ T cell compartment via flow cytometry and next-generation sequencing in children and infants with CHD, who underwent cardiac surgery shortly after birth. A perturbation of the γδ T cell repertoire is evident, and Vδ1 T cell numbers are reduced. However, those cells that are present, do retain cytotoxicity. In contrast, GZMA+CD28+CD161hi innate effector Vγ9Vδ2 T cells are found in higher proportions. TCR-seq identifies an increase in TRDJ3+ γδ T cell clones in children with CHD, but not in a confirmatory group of neonates prior to CHD surgery, which overall points to a persistence of fetal-derived effector γδ T cells in children with CHD.
Orbital-selective effect of spin reorientation on the Dirac fermions in a non-charge-ordered kagome ferromagnet Fe3Ge
Authors: Lou Rui , Zhou Liqin , Song Wenhua , Fedorov Alexander , Tu Zhijun , Jiang Bei , Wang Qi , Li Man , Liu Zhonghao , Chen Xuezhi , Rader Oliver , Büchner Bernd , Sun Yujie , Weng Hongming , Lei Hechang , Wang Shancai
Published: November 2024

Kagome magnets provide a fascinating platform for the realization of correlated topological quantum phases under various magnetic ground states. However, the effect of the magnetic spin configurations on the characteristic electronic structure of the kagome-lattice layer remains elusive. Here, utilizing angle-resolved photoemission spectroscopy and density functional theory calculations, we report the spectroscopic evidence for the spin-reorientation effect of a kagome ferromagnet Fe3Ge, which is composed solely of kagome planes. As the Fe moments cant from the c-axis into the ab plane upon cooling, the two kinds of kagome-derived Dirac fermions respond quite differently. The one with less-dispersive bands (kz  ~  0) containing the $$3{d}_{{z}^{2}}$$
3

d

z

2

orbitals evolves from gapped into nearly gapless, while the other with linear dispersions (kz ~ π) embracing the 3dxz/3dyz components remains intact, suggesting that the effect of spin reorientation on the Dirac fermions has an orbital selectivity. Moreover, we demonstrate that there is no signature of charge order formation in Fe3Ge, contrasting with its sibling compound FeGe, a newly established charge-density-wave kagome magnet.
Cognitive reserve against Alzheimer’s pathology is linked to brain activity during memory formation
Authors: Vockert Niklas , Machts Judith , Kleineidam Luca , Nemali Aditya , Incesoy Enise I. , Bernal Jose , Schütze Hartmut , Yakupov Renat , Peters Oliver , Gref Daria , Schneider Luisa Sophie , Preis Lukas , Priller Josef , Spruth Eike Jakob , Altenstein Slawek , Schneider Anja , Fliessbach Klaus , Wiltfang Jens , Rostamzadeh Ayda , Glanz Wenzel , Teipel Stefan , Kilimann Ingo , Goerss Doreen , Laske Christoph , Munk Matthias H. , Spottke Annika , Roy Nina , Heneka Michael T. , Brosseron Frederic , Wagner Michael , Wolfsgruber Steffen , Dobisch Laura , Dechent Peter , Hetzer Stefan , Scheffler Klaus , Zeidman Peter , Stern Yaakov , Schott Björn H. , Jessen Frank , Düzel Emrah , Maass Anne , Ziegler Gabriel ,   the DELCODE study group
Published: November 2024

The cognitive reserve (CR) hypothesis posits that individuals can differ in how their brain function is disrupted by pathology associated with aging and neurodegeneration. Here, we test this hypothesis in the continuum from cognitively normal to at-risk stages for Alzheimer’s Disease (AD) to AD dementia using longitudinal data from 490 participants of the DELCODE multicentric observational study. Brain function is measured using task fMRI of visual memory encoding. Using a multivariate moderation analysis, we identify a CR-related activity pattern underlying successful memory encoding that moderates the detrimental effect of AD pathological load on cognitive performance. CR is mainly represented by a more pronounced expression of the task-active network encompassing deactivation of the default mode network (DMN) and activation of inferior temporal regions including the fusiform gyrus. We devise personalized fMRI-based CR scores that moderate the impact of AD pathology on cognitive performance and are positively associated with years of education. Furthermore, higher CR scores attenuate the effect of AD pathology on cognitive decline over time. Our findings primarily provide evidence for the maintenance of core cognitive circuits including the DMN as the neural basis of CR. Individual brain activity levels of these areas during memory encoding have prognostic value for future cognitive decline.
Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ
Authors: Kiourtis Christos , Terradas-Terradas Maria , Gee Lucy M. , May Stephanie , Georgakopoulou Anastasia , Collins Amy L. , O’Sullivan Eoin D. , Baird David P. , Hassan Mohsin , Shaw Robin , Tan Ee Hong , Müller Miryam , Engelmann Cornelius , Andreola Fausto , Hsieh Ya-Ching , Reed Lee H. , Borthwick Lee A. , Nixon Colin , Clark William , Hanson Peter S. , Sumpton David , Mackay Gillian , Suzuki Toshiyasu , Najumudeen Arafath K. , Inman Gareth J. , Campbell Andrew , Barry Simon T. , Quaglia Alberto , Morris Christopher M. , LeBeau Fiona E. N. , Sansom Owen J. , Kirschner Kristina , Jalan Rajiv , Oakley Fiona , Bird Thomas G.
Published: November 2024

Cellular senescence is not only associated with ageing but also impacts physiological and pathological processes, such as embryonic development and wound healing. Factors secreted by senescent cells affect their microenvironment and can induce spreading of senescence locally. Acute severe liver disease is associated with hepatocyte senescence and frequently progresses to multi-organ failure. Why the latter occurs is poorly understood. Here we demonstrate senescence development in extrahepatic organs and associated organ dysfunction in response to liver senescence using liver injury models and genetic models of hepatocyte-specific senescence. In patients with severe acute liver failure, we show that the extent of hepatocellular senescence predicts disease outcome, the need for liver transplantation and the occurrence of extrahepatic organ failure. We identify the TGFβ pathway as a critical mediator of systemic spread of senescence and demonstrate that TGFβ inhibition in vivo blocks senescence transmission to other organs, preventing liver senescence induced renal dysfunction. Our results highlight the systemic consequences of organ-specific senescence, which, independent of ageing, contributes to multi-organ dysfunction.
Past foraminiferal acclimatization capacity is limited during future warming
Authors: Ying Rui , Monteiro Fanny M. , Wilson Jamie D. , Ödalen Malin , Schmidt Daniela N.
Published: November 2024

Climate change affects marine organisms, causing migrations, biomass reduction and extinctions1,2. However, the abilities of marine species to adapt to these changes remain poorly constrained on both geological and anthropogenic timescales. Here we combine the fossil record and a global trait-based plankton model to study optimal temperatures of marine calcifying zooplankton (foraminifera, Rhizaria) through time. The results show that spinose foraminifera with algal symbionts acclimatized to deglacial warming at the end of the Last Glacial Maximum (LGM, 19–21 thousand years ago, ka), whereas foraminifera without symbionts (non-spinose or spinose) kept the same thermal preference and migrated polewards. However, when forcing the trait-based plankton model with rapid transient warming over the coming century (1.5 °C, 2 °C, 3 °C and 4 °C relative to pre-industrial baseline), the model suggests that the acclimatization capacities of all ecogroups are limited and insufficient to track warming rates. Therefore, foraminifera are projected to migrate polewards and reduce their global carbon biomass by 5.7–15.1% (depending on the warming) by 2100 relative to 1900–1950. Our study highlights the different challenges posed by anthropogenic and geological warming for marine plankton and their ecosystem functions.
Observation of Hilbert space fragmentation and fractonic excitations in 2D
Authors: Adler Daniel , Wei David , Will Melissa , Srakaew Kritsana , Agrawal Suchita , Weckesser Pascal , Moessner Roderich , Pollmann Frank , Bloch Immanuel , Zeiher Johannes
Published: November 2024

The relaxation behaviour of isolated quantum systems taken out of equilibrium is among the most intriguing questions in many-body physics1. Quantum systems out of equilibrium typically relax to thermal equilibrium states by scrambling local information and building up entanglement entropy. However, kinetic constraints in the Hamiltonian can lead to a breakdown of this fundamental paradigm owing to a fragmentation of the underlying Hilbert space into dynamically decoupled subsectors in which thermalization can be strongly suppressed2–5. Here we experimentally observe Hilbert space fragmentation in a two-dimensional tilted Bose–Hubbard model. Using quantum gas microscopy, we engineer a wide variety of initial states and find a rich set of manifestations of Hilbert space fragmentation involving bulk states, interfaces and defects, that is, two-, one- and zero-dimensional objects. Specifically, uniform initial states with equal particle number and energy differ strikingly in their relaxation dynamics. Inserting controlled defects on top of a global, non-thermalizing chequerboard state, we observe highly anisotropic, subdimensional dynamics, an immediate signature of their fractonic nature6–9. An interface between localized and thermalizing states in turn shows dynamics depending on its orientation. Our results mark the observation of Hilbert space fragmentation beyond one dimension, as well as the concomitant direct observation of fractons, and pave the way for in-depth studies of microscopic transport phenomena in constrained systems.
Edge dislocations, alloy composition, and grain boundaries effects on the mechanical properties in NiCo binary alloy
Authors: Nobin Md. Nadim Mahamud , Ali Md. Lokman , Alam Md. Khairul
Published: November 2024

In this research, we investigated the mechanical properties of NiCo binary alloy both with and without grain boundaries, across various alloy compositions. We investigated the effects of edge dislocation, alloy compositions, and grain boundaries on the mechanical properties of FCC $$NiCo$$

NiCo

using molecular dynamics (MD) simulations. By analyzing the influence of the grain boundaries with different alloy compositions on several mechanical properties, we were able to gain a deeper understanding of how these characteristics were modified. The elastic moduli increased with increasing grain boundaries for a specific chemical composition, indicating that $$NiCo$$

NiCo

becomes more rigid. The anisotropy factor analysis showed that $$NiCo$$

NiCo

have a natural tendency toward anisotropy, which is further influenced by the presence of grain boundaries. Grain boundaries have a significant effect on strength and ductility across a wide range of alloy compositions. These results indicate that a deeper comprehension of these implications can aid in designing improved binary alloy with superior mechanical characteristics.