bluuebunny/crossref_metadata_2025 huggingface dataset:
Examination of preventive effect and safety of chlorine dioxide on nosocomial pneumonia
Authors: Obinata Kaoru
Published: July 2021

Nosocomial infections originate in hospitals. An example of this nosocomial pneumonia, which develops in patients around 48 hours after admission. It has a high mortality rate and occurs in a large number of patients. Professor Kaoru Obinata, Department of Pediatrics, Juntendo University
Urayasu Hospital, Japan, is exploring a novel technique to combat nosocomial pneumonia and other nosocomial infections. This involves the safe and effective application of chlorine dioxide in medical settings and is particularly novel given that, in high doses, chlorine dioxide is toxic and
can cause severe irritation and burns. Obinata and the team are looking at the use of chlorine dioxide gas in conventional induction countermeasures. The researchers believed that, used in combination with a high-efficiency particulate air (HEPA) filter, this method will be highly safe and
boast high prevention effect and cost effectiveness. The team has found that chlorine dioxide aqueous solution is effective against various bacteria, viruses and fungi at a lower concentration than sodium hypochlorite solution and that that low-concentration of chlorine dioxide gas is effective
against airborne bacteria and viruses, as well as adherent bacteria and viruses. Using mouse models, they have shown it to be effective against aerosol infection for the influenza virus and against influenza-like illness in humans. Next, the researchers will find a means of ensuring that the
concentration of chlorine dioxide can be kept to safe and constant levels to ensure the effects are beneficial and not harmful.
COVID-19 health research in low-income countries
Authors: Annette Lucy
Published: July 2021

The COVID-19 pandemic has affected different countries in different ways and to varying extents. Differences in geography and population, as well as the different health response of respective governments, are factors that play a role in the impact of the virus. Unfortunately, the quality
of healthcare systems also plays a key role and there are disparities in healthcare quality across countries. In an initiative led by the National Institute for Health Research (NIHR), in partnership with UK Research and Innovation (UKRI), 12 health research projects across more than 18 countries
are seeking to reduce the impacts of the COVID-19 pandemic across low- and middle-income countries. Topics include transmission and infection control, how people in different settings are affected by the virus and long-term outcomes, including the risk of neurological problems. The projects
have been informed by the World Health Organization COVID-19 Global Research Roadmap, which features four priority research topics relating to the virus: 'epidemiology, clinical management, infection prevention and control, and health system responses'. One project is looking at the impact
of COVID-19 on the mental health of older adults in Peru and another is looking at how the virus affected the brain. A project called the DOMINO Study is investigating the indirect effects of COVID-19 on tuberculosis and HIV care in Indonesia and a project based in a low-resource community
in Rio de Janeiro, Brazil, is working to better understand SARS-CoV-2 in children.
Exploring comprehensive glycan profiles of acquired cystic kidney disease associated renal cell carcinoma to establish a new diagnostic biomarker
Authors: Kawanishi Kunio
Published: July 2021

Acquired cystic kidney disease (ACKD) is characterized by the development of numerous renal cysts. Incidence of ACKD is higher amongst patients on haemodialysis and the longer a patient receives this treatment, the more likely ACKD is to occur. Assistant Professor Kunio Kawanishi, Faculty
of Medicine, University of Tsukuba, Japan, is focusing on acquired cystic kidney disease associated renal cell carcinoma (ACD-RCC), which is an unique and major type of RCC in haemodialysis patients. He and his team are investigating comprehensive glycan profiles of ACD-RCC to detect possible
biomakers. If a useful biomarker can be discovered, disease diagnosis could be improved and therapeutic targets for treatment could be provided. In his current project, Kawanishi is exploring the significance of sialic acid modification and accumulation of ketodeoxynonulosonic acid (Kdn) in
end-stage renal disease (ESRD). He is using different techniques to decipher how Kdn and other sialic acids react and circulate within the human body. Kawanishi linked into the TIA collaborative network, which enabled him to access invaluable samples for next generation sequencing, enabling
him to determine mRNA expression and perform glycan analysis with lectin microarray. Currently, the researchers are using mass spectrometry to detect ACD-RCC specific glycostructure for establishing ELISA. Next, the team will identify the lectin and antibody specific to the glycan and its
carrier protein.
Research on the collaboration between educators and medical practitioners of children with 22q11.2 deletion syndrome at schools
Authors: Kitamura Chiaki
Published: July 2021

22q11.2 deletion syndrome (22q11.2 DS), also known as DiGeorge syndrome, or Velocardiofacial syndrome, is a disorder caused by a small amount of genetic material (DNA) missing from one of the chromosomes that are in each cell of our bodies. That tiny missing piece of the 22nd chromosome
can cause a wide variety of problems that present from birth, such as defects in the heart and other organs, intellectual disabilities and learning difficulties, developmental delays and neuorodevelopmental disorders in some people, while others can go through life without realising they have
it. Family members of individuals with the disorder are also likely to be affected, which is why efforts are being made to assist the families of people with 22q11.2 DS. Associate Professor Chiaki Kitamura, Faculty of Nursing, Seisen Jogakuin College, Japan, is a researcher doing just this.
In particular, she wants to ensure that individuals with the disorder receive educational support from an early stage and that their family, caregivers and siblings learn about and understand 22q11.2 DS. In their project, Kitamura and her team are exploring the collaboration between educators
and medical practitioners of children with 22q11.2 DS at schools. Kitamura wishes to identify a means of explaining the condition in a simple and effective manner and hopes this knowledge will improve the lives of patients and their families. As such, the team has developed a learning support
guide to be used by educators and the families of 22q11.2 DS patients. The goal of the guide is to enhance the cooperation between medical care staff and educators. The researchers will disseminate the guide and facilitate understanding of the diversity of individuals with 22q11.2 DS, thereby
promoting medical education.
Logical structure of acceptance and exclusion in the history of mental health and welfare
Authors: Utsunomiya Minori
Published: July 2021

Early traditional mental health policies in Japan did not protect the rights of patients with mental illnesses, with public safety prioritised over human rights. The situation has since improved, but these early perceptions have impacted on current mental health policies in Japan. Dr
Minori Utsunomiya, Aichi Prefectural University, Japan, believes past policies are the root of many challenges facing people with mental illness and she is exploring Japan's complex history of mental health and psychiatric care to shed light on the correlation between past and present mental
health policies. Key foci for Utsunomiya are the Psychiatric Custody Law of 1900, the Psychiatric Hospital Law of 1919 and the Mental Health Act of 1950 and she is exploring these laws from two perspectives: pre-World War II to post-war continuity/discontinuity and the structure of acceptance
and exclusion for people with mental illnesses. As such, Utsunomiya embarked on an exploration of the process of the revision and abolition of laws and deliberation with respect to bills related to mental illness, investigated the roles and functions of public psychiatric hospitals and analysed
the causal relationship between the revision of laws related to mental illness and social incident.
Devising a fertility education guide relating to future pregnancy, childbirth and the formation of the family for high school students
Authors: Akizuki Yuri
Published: July 2021

High school sex education tends to focus on safe sex and preventing unwanted pregnancies. It is rarely mentioned that pregnancy is not a guaranteed outcome of unprotected sex. Some people will be unable to have children in the future and this is an eventuality that high school sex education
should prepare students for. Dr Yuri Akizuki, Faculty of Life Sciences, Kumamoto University, Japan, is creating and developing an infertility prevention education programme for high school students. In doing so, her goal is to reduce the number of people who want to have children but cannot
have them, and ensure that younger people have knowledge of fertility. When working in a gynecological clinic during her studies, Akizuki encountered stories from women who faced infertility and weren't equipped with important knowledge on the topic and this experience provided the inspiration
for her current work. In the short term, Akizuki wants to ensure high school teachers are equipped with the skills and experience to teach and recognise the importance of fertility knowledge. In the long term, she hopes her work can help people to get pregnant later in life and even halt Japan's
declining birth rate. It is necessary to ensure that local and national governments understand the importance of fertility knowledge in order that fertility education can be provided to high school students. Akizuki and her team hope that their guide can be used as an important aid to sex
education in high schools.
Ultra-early cancer diagnosis and label-free circulating tumor cell detection by comprehensive analysis of blood and urine using spectroscopy
Authors: Ito Hiroaki
Published: July 2021

Detecting cancers early on leads to better chances of successful treatment and long-term survival. There is no single test to diagnose cancers but available diagnostic procedures include diagnostic imaging, endoscopic exams and tumour biopsies. Prostate cancer is one of the most frequently
diagnosed cancers and a prostate-specific antigen test (PSA) can be used in the detection of this type of cancer. This involves measuring the amount of PSA in the blood, with elevated levels possibly indicating prostate cancer. However, there are risks and limitations associated with existing
diagnostic methods. Raman spectroscopy is an optical technique that shows promise in cancer diagnosis but there is room for improvement. At the Digestive Diseases Center, Showa University Koto Toyosu Hospital, Japan, researchers are using surface-enhanced Raman scattering (SERS) in the development
of an ultra-early cancer diagnosis technology. Associate Professor Hiroaki Ito is collaborating with Associate Professor Uragami Naoyuki and Professors Noboru Yokoyama and Takashi Fukagai on this work and the researchers have established a high-sensitivity quantitative technology that uses
near-infrared lasers as the excitation light source. The researchers have also developed a colorectal cancer prediction model based on Raman spectroscopy and, in another line of work, have developed a method for generating silver nanoscale hexagonal columns (NHCs) for use in SERS. Ultimately,
Ito and the team hope their research will lead to enhanced cancer treatment results and improved quality of life for patients.
Penerapan Aplikasi Database pada Kegiatan Manajemen Sekolah
Authors: Wijaya Widia Murni , Subekti Zaenal Mutaqin
Published: July 2021

Penelitian ini bertujuan untuk mengetahui penerapan aplikasi database untuk mengolah data, pemenuhan kebutuhan sistem (hardware dan software), dan kebutuhan pengguna (brainware) untuk mendukung penerapan aplikasi database pada kegiatan manajemen sekolah. Penelitian ini menggunakan metode kualitatif dengan mengamati dan mencatat fakta-fakta yang dilakukan melalui observasi, wawancara, dan dokumentasi. Penelitian dilaksanakan di tiga sekolah menengah pertama negeri. Informan penelitian ini terdiri dari tenaga kependidikan dan pendidik. Hasil penelitian menunjukkan bahwa sekolah-sekolah yang diteliti telah menerapkan aplikasi database untuk mengolah data pada kegiatan manajemen sekolah, pemenuhan kebutuhan sistem (hardware dan software) telah disesuaikan dengan perkembangan tren teknologi terbaru, dan pemenuhan kebutuhan pengguna (brainware) telah dikelola dengan baik melalui pelatihan yang berkesinambungan untuk meningkatkan kemampuan para tenaga kependidikan dan pendidik.
Pengaruh Kepemimpinan Kepala Sekolah, Supervisi Pendidikan dan Budaya Sekolah Terhadap Kinerja Guru Sekolah Dasar Negeri
Authors: Jabar Cepi Safruddin Abdul , Susilo Tri Joko
Published: July 2021

Penelitian ini bertujuan untuk mengetahui pengaruh kepemimpinan kepala sekolah, supervisi pendidikan dan budaya sekolah terhadap kinerja guru. Lokasi penelitian yaitu sekolah dasar negeri (SDN) di Kecamatan Kajoran Kabupaten Magelang. Penelitian ini menggunakan pendekatan kuantitatif. 144 guru dipilih sebagai sampel penelitian dengan teknik area proportionate random sampling. Pengumpulan data menggunakan kuesioner. Pengujian hipotesis menggunakan rumus regresi sederhana dan ganda. Hasil penelitian menunjukkan terdapat pengaruh yang positif dan signifikan antara kepemimpinan kepala sekolah, supervisi pendidikan dan budaya sekolah terhadap kinerja guru secara sendiri-sendiri atau bersama-sama. Implikasinya yaitu peningkatan kinerja guru perlu memperhatikan ketiga variabel yang mempengaruhi tersebut.
Evaluasi Kualitatif Program Pendidikan dan Pelatihan Calon Kepala Sekolah Model In-On-In
Authors: Andriani Dwi Esti , Juliyanti Dinar Tri , Suyud Suyud , Mustiningsih Mustiningsih , Arifin Arifin
Published: July 2021

Penelitian ini bertujuan untuk mengevaluasi program penyiapan calon kepala sekolah dengan model in-on-in.  Fokus penelitiannya yaitu pada pelaksanaan pendidikan dan pelatihan (diklat) yang terdiri dari tahap in-service learning 1 (ISL1), on the job learning (OJL), dan in-service learning 2 (ISL2). Penelitian menggunakan pendekatan kualitatif. Pengumpulan data dilakukan dengan wawancara semi terstruktur kepada lulusan program dan studi dokumentasi. Data yang terkumpul kemudian dianalisis secara kualitatif. Kriteria dependabilitas, kredibilitas, transferabilitas, dan komfirmabilitas diterapkan untuk menjamin kualitas data. Hasil penelitian menunjukkan bahwa pengembangan program pendidikan dan pelatihan (diklat) calon kepala sekolah (CKS) di Indonesia secara umum senada dengan trend pengembangan program penyiapan CKS  di berbagai negara. Kurikulumnya komperhensif dan koheren yang mengkaitkan antara pengetahuan teoritis yang diberikan melalui pembelajaran di kelas dengan pengetahuan dan keterampilan praktis melalui magang di sekolah pada tahap OJL. Diklat juga telah menerapkan pendekatan pembelajaran orang dewasa dan mengevaluasi tingkat penguasaan kompetensi peserta diklat. Model diklat ini dirasakan lulusan telah mendukung penguasaan kompetensi kepala sekolah yang mereka butuhkan saat menjabat. Namun demikian, hasil evaluasi menunjukkan bahwa masih terdapat beberapa aspek dari komponen pelaksanaan diklat yang perlu ditingkatkan. Aspek tersebut yaitu: relevansi kurikulum dengan tugas pekerjaan dan tanggung jawab kepala sekolah saat ini, kualitas mentor dan pementorannya saat peserta melaksanakan magang di sekolah.
Level of Satisfaction on Sports Facilities and Infrastructure among Students of Sport-Specific Class in A Senior High School
Authors: Abusamra Asmaa , Lestari Slamet , Fajri Dyssa Arfiesta Valentin
Published: July 2021

This study aims to investigate the students’ levels of satisfaction on sport-specific class facilities and infrastructure in SMA N 4 Yogyakarta. This is a quantitative descriptive study that involves as many as 64 students of the tenth and eleventh grades of sport-specific classes. The data of this study were collected through surveys and observations before being analyzed using the descriptive statistics method. The results of this study show that the student level of satisfaction on sports facilities and infrastructure in SMA N 4 Yogyakarta is in the "moderate" category. Furthermore, seen from the categories of the service quality determinants, the aspect of reliability is in the “high” category while the tangibility is in the “very low” category.
Pengaruh Gaya Kepemimpinan Transformasional Kepala Sekolah Terhadap Etos Kerja Guru dan Staf
Authors: Fadhilah Muhammad Luthfi Zharfan , Suryadi Suryadi , Abubakar Abubakar
Published: July 2021

Kepemimpinan transformasional berfokus pada pencapaian perubahan nilai-nilai, kepercayaan, sikap, perilaku, emosional, dan kebutuhan staf menuju perubahan yang lebih baik di masa depan. Penelitian ini bertujuan untuk mengetahui pengaruh gaya kepemimpinan transformasional kepala sekolah terhadap etos kerja guru dan staf. Sampel penelitian ini yaitu 56  guru dan staf di Sekolah Menengah Pertama Negeri 12 Bandung. Pengumpulan data dilakukan dengan kuesioner. Data yang terkumpul dianalisis secara kuantitatif  menggunakan  program Microsoft Excel 2016 dan SPSS 20 for windows. Hasil penelitian menunjukkan bahwa ada hubungan yang signifikan antara gaya kepemimpinan transformasional kepala sekolah dan etos kerja guru beserta staf dengan nilai koefisien sebesar 0,370. Selain itu, gaya kepemimpinan transformasional kepala sekolah berpengaruh sebesar 13,7% terhadap etos kerja guru dan staf. Jika gaya kepemimpinan transformasional kepala sekolah ditingkatkan sebesar 53,483 maka nilai etos kerja guru dan staf akan bertambah sebesar 0,260. Berdasarkan hasil penelitian tersebut, penelitian ini merekomendasikan perlunya pengembangan dan penerapan kepemimpinan transformasional kepala sekolah.
Pengaruh Kompetensi Profesional, Motivasi Kerja dan Disiplin Kerja terhadap Kinerja Guru Sekolah Menengah Atas Negeri se-Kabupaten Pemalang
Authors: Rahmayanti Rahmayanti , Haryati Titik , Miyono Noor , Safitri Ayunda
Published: July 2021

Kinerja guru dalam menjalankan perannya dipengaruhi oleh beberapa faktor yaitu profesionalisme, motivasi, dan disiplin dalam bekerja. Penelitian ini bertujuan untuk mengetahui pengaruh kompetensi profesional, motivasi kerja, dan disiplin kerja terhadap kinerja guru sekolah menengah atas (SMA) negeri se-Kabupaten Pemalang. Penelitian ini termasuk dalam penelitian ex-post facto dan bersifat kuantitatif. Jumlah sampel penelitian ini sebanyak 200 guru dari sepuluh sekolah. Teknik pengumpulan data menggunakan angket. Data yang terkumpul dianalisis secara kuantitatif. Hasil penelitian menunjukkan kompetensi profesional, motivasi kerja, dan disiplin kerja berpengaruh terhadap kinerja guru baik secara terpisah atau bersama-sama.
Digital Health Training Programs for Medical Students: Scoping Review (Preprint)
Authors: Tudor Car Lorainne , Kyaw Bhone Myint , Nannan Panday Rishi S , van der Kleij Rianne , Chavannes Niels , Majeed Azeem , Car Josip
Published: July 2021

BACKGROUND

Medical schools worldwide are accelerating the introduction of digital health courses into their curricula. The COVID-19 pandemic has contributed to this swift and widespread transition to digital health and education. However, the need for digital health competencies goes beyond the COVID-19 pandemic because they are becoming essential for the delivery of effective, efficient, and safe care.

OBJECTIVE

This review aims to collate and analyze studies evaluating digital health education for medical students to inform the development of future courses and identify areas where curricula may need to be strengthened.

METHODS

We carried out a scoping review by following the guidance of the Joanna Briggs Institute, and the results were reported in accordance with the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) guidelines. We searched 6 major bibliographic databases and gray literature sources for articles published between January 2000 and November 2019. Two authors independently screened the retrieved citations and extracted the data from the included studies. Discrepancies were resolved by consensus discussions between the authors. The findings were analyzed using thematic analysis and presented narratively.

RESULTS

A total of 34 studies focusing on different digital courses were included in this review. Most of the studies (22/34, 65%) were published between 2010 and 2019 and originated in the United States (20/34, 59%). The reported digital health courses were mostly elective (20/34, 59%), were integrated into the existing curriculum (24/34, 71%), and focused mainly on medical informatics (17/34, 50%). Most of the courses targeted medical students from the first to third year (17/34, 50%), and the duration of the courses ranged from 1 hour to 3 academic years. Most of the studies (22/34, 65%) reported the use of blended education. A few of the studies (6/34, 18%) delivered courses entirely digitally by using online modules, offline learning, massive open online courses, and virtual patient simulations. The reported courses used various assessment approaches such as paper-based assessments, in-person observations, and online assessments. Most of the studies (30/34, 88%) evaluated courses mostly by using an uncontrolled before-and-after design and generally reported improvements in students’ learning outcomes.

CONCLUSIONS

Digital health courses reported in literature are mostly elective, focus on a single area of digital health, and lack robust evaluation. They have diverse delivery, development, and assessment approaches. There is an urgent need for high-quality studies that evaluate digital health education.
Implementing the Co-Immune Open Innovation Program to Address Vaccination Hesitancy and Access to Vaccines: Retrospective Study (Preprint)
Authors: Masselot Camille , Greshake Tzovaras Bastian , Graham Chris L B , Finnegan Gary , Jeyaram Rathin , Vitali Isabelle , Landrain Thomas , Santolini Marc
Published: July 2021

BACKGROUND

The rise of major complex public health problems, such as vaccination hesitancy and access to vaccination, requires innovative, open, and transdisciplinary approaches. Yet, institutional silos and lack of participation on the part of nonacademic citizens in the design of solutions hamper efforts to meet these challenges. Against this background, new solutions have been explored, with participatory research, citizen science, hackathons, and challenge-based approaches being applied in the context of public health.

OBJECTIVE

Our aim was to develop a program for creating citizen science and open innovation projects that address the contemporary challenges of vaccination in France and around the globe.

METHODS

We designed and implemented Co-Immune, a program created to tackle the question of vaccination hesitancy and access to vaccination through an online and offline challenge-based open innovation approach. The program was run on the open science platform Just One Giant Lab.

RESULTS

Over a 6-month period, the Co-Immune program gathered 234 participants of diverse backgrounds and 13 partners from the public and private sectors. The program comprised 10 events to facilitate the creation of 20 new projects, as well as the continuation of two existing projects, to address the issues of vaccination hesitancy and access, ranging from app development and data mining to analysis and game design. In an open framework, the projects made their data, code, and solutions publicly available.

CONCLUSIONS

Co-Immune highlights how open innovation approaches and online platforms can help to gather and coordinate noninstitutional communities in a rapid, distributed, and global way toward solving public health issues. Such initiatives can lead to the production and transfer of knowledge, creating novel solutions in the public health sector. The example of Co-Immune contributes to paving the way for organizations and individuals to collaboratively tackle future global challenges.
Benefits of, Barriers to, and Needs for an Artificial Intelligence–Powered Medication Information Voice Chatbot for Older Adults: Interview Study With Geriatrics Experts (Preprint)
Authors: Gudala Meghana , Ross Mary Ellen Trail , Mogalla Sunitha , Lyons Mandi , Ramaswamy Padmavathy , Roberts Kirk
Published: July 2021

BACKGROUND

One of the most complicated medical needs of older adults is managing their complex medication regimens. However, the use of technology to aid older adults in this endeavor is impeded by the fact that their technological capabilities are lower than those of much of the rest of the population. What is needed to help manage medications is a technology that seamlessly integrates within their comfort levels, such as artificial intelligence agents.

OBJECTIVE

This study aimed to assess the benefits, barriers, and information needs that can be provided by an artificial intelligence–powered medication information voice chatbot for older adults.

METHODS

A total of 8 semistructured interviews were conducted with geriatrics experts. All interviews were audio-recorded and transcribed. Each interview was coded by 2 investigators (2 among ML, PR, METR, and KR) using a semiopen coding method for qualitative analysis, and reconciliation was performed by a third investigator. All codes were organized into the benefit/nonbenefit, barrier/nonbarrier, and need categories. Iterative recoding and member checking were performed until convergence was reached for all interviews.

RESULTS

The greatest benefits of a medication information voice-based chatbot would be helping to overcome the vision and dexterity hurdles experienced by most older adults, as it uses voice-based technology. It also helps to increase older adults’ medication knowledge and adherence and supports their overall health. The main barriers were technology familiarity and cost, especially in lower socioeconomic older adults, as well as security and privacy concerns. It was noted however that technology familiarity was not an insurmountable barrier for older adults aged 65 to 75 years, who mostly owned smartphones, whereas older adults aged >75 years may have never been major users of technology in the first place. The most important needs were to be usable, to help patients with reminders, and to provide information on medication side effects and use instructions.

CONCLUSIONS

Our needs analysis results derived from expert interviews clarify that a voice-based chatbot could be beneficial in improving adherence and overall health if it is built to serve the many medication information needs of older adults, such as reminders and instructions. However, the chatbot must be usable and affordable for its widespread use.
Implementation Frameworks for Artificial Intelligence Translation Into Health Care Practice: Scoping Review (Preprint)
Authors: Gama Fábio , Tyskbo Daniel , Nygren Jens , Barlow James , Reed Julie , Svedberg Petra
Published: July 2021

BACKGROUND

Significant efforts have been made to develop artificial intelligence (AI) solutions for health care improvement. Despite the enthusiasm, health care professionals still struggle to implement AI in their daily practice.

OBJECTIVE

This paper aims to identify the implementation frameworks used to understand the application of AI in health care practice.

METHODS

A scoping review was conducted using the Cochrane, Evidence Based Medicine Reviews, Embase, MEDLINE, and PsycINFO databases to identify publications that reported frameworks, models, and theories concerning AI implementation in health care. This review focused on studies published in English and investigating AI implementation in health care since 2000. A total of 2541 unique publications were retrieved from the databases and screened on titles and abstracts by 2 independent reviewers. Selected articles were thematically analyzed against the Nilsen taxonomy of implementation frameworks, and the Greenhalgh framework for the nonadoption, abandonment, scale-up, spread, and sustainability (NASSS) of health care technologies.

RESULTS

In total, 7 articles met all eligibility criteria for inclusion in the review, and 2 articles included formal frameworks that directly addressed AI implementation, whereas the other articles provided limited descriptions of elements influencing implementation. Collectively, the 7 articles identified elements that aligned with all the NASSS domains, but no single article comprehensively considered the factors known to influence technology implementation. New domains were identified, including dependency on data input and existing processes, shared decision-making, the role of human oversight, and ethics of population impact and inequality, suggesting that existing frameworks do not fully consider the unique needs of AI implementation.

CONCLUSIONS

This literature review demonstrates that understanding how to implement AI in health care practice is still in its early stages of development. Our findings suggest that further research is needed to provide the knowledge necessary to develop implementation frameworks to guide the future implementation of AI in clinical practice and highlight the opportunity to draw on existing knowledge from the field of implementation science.
Investigation of the effect of porous titanium cups on stress distribution in bone tissue (mathematical modeling)
Authors: Bondarenko S.Ye. , Denisenko S.A. , Karpinsky M.Yu. , Yaresko O.V.
Published: July 2021

Introduction. During arthroplasty in patients with altered anatomy and osteoporosis of the acetabulum, stable fixation of the acetabular component of the endoprosthesis is a very difficult task. There are studies on the bone tissue bonding to titanium, tantalum and ceramic coatings of endoprostheses. However, there are insufficient data on the influence of the strength characteristics of modern surfaces of the cups for hip endoprostheses on the distribution of mechanical stresses in the bone tissue around the implanted components. The purpose was to study on a mathematical model the changes in the stress-strain state of the endoprosthesis-bone system as a result of using porous tantalum cup. Materials and methods. A mathematical modeling has been carried out of the stress-strain state of the human hip joint in arthroplasty with porous cup. Du-ring the study, a defect in the acetabular roof filled with a bone implant fixed with two screws was simulated, as well as a defect in the acetabular floor filled with bone “chips”. Endoprosthesis cups were modeled in two versions: from solid titanium with a spray coating of porous titanium, and those entirely made of porous titanium. A distributed load of 540 N was applied to the sacrum. A load was applied between the iliac wing and the greater trochanter of the femur simulating the action of the gluteus medius — 1150 N and the gluteus minimus — 50 N. Results. The use of a cup with a coating of porous titanium in the normal state of the acetabulum leads to the occurrence of maximum stresses (15.9 MPa) in its posterior-upper part. Minimum stresses of 4.6 MPa are observed in the center of the acetabulum. The use of an endoprosthesis with porous titanium cup allows reducing the level of stresses in the bone tissue around the cup. If there is a defect in the acetabular roof, a hip endoprosthesis with porous titanium cup causes less stress than a solid titanium cup with coating of porous titanium. But on the graft, the stress level remains practically unchanged, regardless of the type of cup. The use of porous tantalum cup in the presence of a defect in the acetabular floor causes significantly less stress in the bone tissue around it, compared to an all-metal cup with coating. Conclusions. The cup of the hip endoprosthesis made of porous titanium causes significantly less stress in all control points of the model, compared to a cup made of solid titanium with coating of porous titanium, both with defects in the acetabular roof and floor, and without bone defects.
3D modeling in the planning of treatment of femoral tumors
Authors: Drobotun O.V.
Published: July 2021

Background. The outcome of surgical treatment of fe-moral tumors (FT) depends on the knowledge of the real picture of the extent of bone and soft tissue damage. The objective picture of the lesion can be significantly supplemented by virtual modeling in the framework of MRI, CT, and 3D modeling of the process, which is practically not studied in Ukraine. Real solid modeling of a skeletal segment with a tumor can produce the most optimal volume of resection and structure formation for stable fixation of bone fragments. The purpose of the work is to improve the technique of 3D modeling of hip tumors for preoperative planning of surgical intervention and the development of the most optimal design of the device. Materials and methods. The available literature data were analyzed; the radiographs, case histories of 15 patients with FT were studied. Good results of treatment of the last are possible at thorough preoperative planning. Results. We use technologies of 3D modeling and 3D printing of solid models of FT. This allows planning the line of the proposed bone resection, to properly form a graft from bioactive ceramics, tutoplast or own bones. 3D modeling helps to create the most optimal design of the device, which provides stable fixation of these grafts to the femoral fragments. The length of resection of the tumor segment with the tumor was calculated using multidetector compu-ted tomography (MDC) perfusion. This makes it possible to conduct preoperative training to establish the structures of the formed fixators on the segment of bone fragments — graft (BFG), to determine its bearing capacity. Based on planning and preoperative training, 5 ope-rations were performed on the hip. To stabilize the BFG segment, optimized constructions based on a DHS-type clamp, LCP-plates, or a clamp for low-contact multiplane osteosynthesis were used. Conclusions. Application of the technology of 3D modeling and 3D printing of solid models of specific SC and tumors allow planning the line of the proposed bone resection. Based on this, you can form the size of the graft, create a fixator structure that provides stability in the BFG. The preoperative training facilitates surgery. All this helps to choose the most optimal treatment tactics.
The use of the combined stable-elastic fixation for unstable injuries of the ankle joint in trans-syndesmotic fractures of the tibia
Authors: Chuzhak A.V.
Published: July 2021

The problem of complications and the frequency of poor outcomes in the surgical treatment of ankle fractures with ti-biofibular syndesmosis (TFS) rupture (4.8–36.8 % of cases) remains significant. It was interesting from a scientific and practical point of view to conduct a clinical study to determine the effectiveness of the newly developed method of metal osteosynthesis for tibial fractures with TFS rupture, which would combine stability of tibial fixation and not limit the elastic qualities of TFS. The aim of the study: to determine the effectiveness of combined stable-elastic fixation for unstable injuries of the ankle joint in trans-syndesmotic fractures of the tibia. Materials and methods. On the basis of own clinical researches and data of literature sources, the method of the combined stable-elastic fixation for unstable injuries of the ankle joint in trans-syndesmotic fractures of the tibia is developed. The effectiveness of the proposed technique was evaluated 6 months after surgery on the Kitaoka scale. We have examined 12 patients with tibial fractures type 44 B1, B2 and B3 according to the AO classification, who underwent surgery using our methods. Results. The high efficiency of using the technique of combined stable-elastic fixation for unstable injuries of the ankle joint due to trans-syndesmotic fractures of the tibia has been determined. Good and excellent treatment results 6 months after surgery were observed in all 12 people (100 %), with excellent outcomes observed in 75 % of cases. There were no satisfactory and unsatisfactory treatment results. Conclusions. The study proves the high efficiency of the proposed method for combined stable-elastic fixation of ankle injuries in unstable trans-syndesmotic fractures of the tibia with TFS damage. There were 75 % excellent and 25 % good results within 6 months after surgery. A wider introduction of this technique into the practice of traumatologists of Ukraine is proposed.
Ukrainian FRAX version in the male osteoporosis management
Authors: Povoroznyuk V.V. , Johansson H. , Grygorieva N.V. , Kanis J.A. , Musiіenko А.S. , Lorentzon M. , Harvey N.C. , McCloskey E.V. , Liu E.
Published: July 2021

Background. At present, FRAX is a well-known and widely-used risk assessment tool for major osteoporotic fractures. The Ukrainian version of the FRAX algorithm was presented in 2016; with the “intervention threshold” for additional DXA examination and antiosteoporotic treatment of the Ukrainian women published in 2019. However, the data on its possible uses in men are limited. The purpose of the study was to evaluate the possibilities of using the previously developed criteria of the Ukrainian FRAX algorithm in Ukrainian men. Materials and methods. We examined 653 outpatients aged 40–88 years (mean age (M±SD)— 60.5±11.8 years). We analyzed the results both in the general group and in the age subgroups; in particular, with an account of low-trauma fractures, included in the FRAX calculation, and compared them with the corresponding indices of the Ukrainian women. Results. The most frequent (26.6 %) risk factor for osteoporotic fractures in the group of Ukrainian men was a history of low-trauma fracture (the corresponding index in women was 51.3 %), its presence being the reason for antiosteoporotic treatment initiating. Following upon the risk of major osteoporotic fractures calculated by FRAX, only 6.7 % of men without previous fractures were found to require additional DXA examination in order to re-evaluate the osteoporotic fracture risk, and none had a high fracture risk. 73 % of men without fractures did not have any risk factor included in the FRAX algorithm. Conclusions. This study showed a greater need for both antiosteoporotic treatment without DXA assessment and additional densitometric examination for the osteoporotic fracture risk assessment for the Ukrainian women rather than men, along with a special attention to the presence of previous fractures in men, and consideration of other risk factors for osteoporosis, even those not included in this FRAX algorithm.
Life quality of men with ankylosing spondylitis: association with the disease course and the structural and functional state of bone tissue
Authors: Shevchuk S.V. , Pavliuk O.M.
Published: July 2021

Background. Multiple peculiarities of ankylosing spondylitis clinical course have a significant influence on the physical, mental and social status of patients. Systemic loss of bone tissue manifesting itself through the development of osteoporosis and its complications is not excluded either. However, currently there is no sufficiently clear information on the influence of osteoporosis or its metabolic components, as well as peculiarities of the disease clinical course on the physical and mental health components in the patients suffering from ankylosing spondylitis. Purpose: to study the quality of life indices using the SF-36 and HAQ questionnaires in men suffering from ankylosing spondylitis and to assess the associations of these indexes with the disease clinical course as well as structural and functional state of bone tissue. Materials and methods. 105 men suffering from ankylosing spondylitis and 25 practically healthy persons of the appropriate age and sex forming the control group were examined. In order to assess the quality of life indices, the SF-36 and HAQ questionnaires were used. Results. It was established that men suffering from ankylosing spondylitis showed reliably lower indices of physical (37.3±1.5 points) and mental (44.2 ± 1.7 points) health components if compared to the control group (99.1 ± 0.3; 97.4±0.7 points respectively). Under conditions of the low bone mineral density, quality of life indices (PCS; MCS) were only 12.2–7.1% lower than in the patients with a preserved bone mineral density. It was shown that under conditions of the Vitamin D deficiency, quality of life components were significantly worse, specifically on account of the mental health component (р < 0.05). It was also established that the lower quality of life was closely associated with a high activity of the inflammatory process (ASDAS-СRP, BASDAI) and a high dose of glucocorticoids. Conclusions. Men suffering from ankylosing spondylitis show a significant reduction of life quality indices by the SF-36 (PCS; MCS) and HAQ questionnaires, which demonstrate no association with the age of the patients (except for MCS), disease form and duration, structural and functional state of bone tissue. However, they are significantly worse in subjects with the Vitamin D deficiency, a high dose of glucocorticoids and high disease activity.
Media Sosial dan Connective Action: Studi Kasus Penggunaan Twitter sebagai Ruang Solidaritas selama Pandemi COVID-19
Authors: Kristianto Kristianto , Ramadhan Abdul Basith , Marsetyo Fernandito Dikky
Published: July 2021

Tulisan ini membahas munculnya aksi solidaritas di media sosial Twitter. Dengan menggunakan kerangka teori connective action dan efektivitas gerakan di media sosial, tulisan ini bertujuan untuk menjelaskan bagaimana aksi solidaritas di Twitter muncul dan menjelaskan aktor yang terlibat di dalamnya. Selain itu, tulisan ini juga bertujuan untuk menjelaskan efektivitas dari aksi solidaritas. Penelitian dilakukan dengan analisis media sosial dan analisis konten. Penelitian menunjukkan bahwa aksi solidaritas yang muncul di Twitter merupakan respons atas situasi krisis akibat pandemi COVID-19. Meskipun merespons isu dalam rentang waktu yang sama dan menggunakan narasi yang serupa, aksi solidaritas yang dimunculkan oleh individu, organisasi, dan komunitas dilakukan secara personal dan tidak saling terikat secara langsung. Namun demikian, tidak semua aksi solidaritas mendapatkan impresi/engagement yang tinggi. Aktor yang menjadi opinion leader, yang dipengaruhi oleh faktor indegree, retweet dan mention, memiliki pengaruh besar dalam melakukan aksi solidaritas. 

 

This article discusses the emergence of solidarity actions on Twitter social media. Using the framework of connective action and the effectiveness of social media movements, this paper aims to explain how solidarity actions on Twitter emerge and explain the actors involved in it. Besides, this paper also aims to explain the effectiveness of solidarity actions. The research was conducted with social media analysis and content analysis. Research shows that the solidarity action that appears on Twitter is a response to the crisis caused by the COVID-19 pandemic. Although responding to issues in the same time frame and using similar narratives, solidarity actions raised by individuals, organizations, and communities are carried out personally and are not directly tied to each other. However, not all solidarity actions received high impressions/engagement. Actors who are opinion leaders, who are influenced by indegree, retweet, and mention factors, have a big influence in carrying out solidarity actions. 

Keywords: solidarity; crisis; opinion leader; twitter; connective action
Implementasi Program Jaminan Kesehatan Khusus Terpadu dalam Upaya Perlindungan dan Pemenuhan Hak Kesehatan Penyandang Disabilitas
Authors: Ardiyantini Rut Dwi
Published: July 2021

Program Jamkesus Terpadu digulirkan oleh Pemerintah Daerah DIY melalui Bapel Jamkesos DIY untuk mewujudkan perlindungan dan pemenuhan hak kesehatan penyandang disabilitas dengan cara mempermudah, mendekatkan, memfasilitasi, dan memberikan jaminan. Penelitian ini bertujuan untuk mengetahui implementasi program tersebut di Kabupaten Gunungkidul. Penelitian ini menggunakan metode kualitatif dengan penekanan pada pendekatan deskriptif. Informan penelitian ini berjumlah 13 orang yang dipilih melalui teknik purposive sampling dan snowball sampling. Teknik pengumpulan data dilakukan dengan wawancara mendalam, observasi, dan dokumentasi. Hasil penelitian menunjukkan bahwa implementasi berdasarkan analisis keluaran program dari tujuh indikator, masih memuat masalah pada lima indikator tersebut yaitu cakupan, frekuensi, bias, ketepatan layanan, dan akuntabilitas. Namun demikian, hasil implementasi juga menunjukkan bahwa program tersebut telah memberikan dampak yang dapat dirasakan manfaatnya secara langsung. Akan tetapi, pada dampak jangka menengah menunjukkan masih belum sepenuhnya bisa dirasakan dan pada dampak jangka panjang juga masih menjadi harapan program untuk ke depannya. 

Kata kunci: Jamkesus Terpadu, Penyandang Disabilitas, Perlindungan dan Pemenuhan Hak Kesehatan 

 

Jamkesus Terpadu program is launched by the Provincial Government of DIY to realize the protection and fulfillment of health rights for persons with disabilities by making it easier, closer, facilitating, and giving the guarantee. This research aims to know the program’s implementation in Gunungkidul Regency. This research used a qualitative method with an emphasis on descriptive approach. There are 13 informants, who were selected through purposive sampling and snowball sampling techniques. Data collection is done through in-depth interview, observation, and documentation. The research result shows that the implementation based on an analysis of the program’s output from seven indicators that still contained problems there were five indicators namely coverage, frequency, bias, the accuracy of service, and accountability. Although the outcome of the program shows that the impact of the program can be felt directly. The medium-term impact shows not yet fully felt. Furthermore, the long-term impact is still the expectation of future programs. 

Keywords: Jamkesus Terpadu, Persons with Disabilities, Protection and Fulfillment of Health Rights