bluuebunny/crossref_metadata_2025 huggingface dataset:
The short-term associations of chronic obstructive pulmonary disease hospitalizations with meteorological factors and air pollutants in Southwest China: a time-series study
Authors: Li Meng , Chen Shengqi , Zhao Hanqing , Tang Chengxiang , Lai Yunfeng , Ung Carolina Oi Lam , Su Jinya , Hu Hao
Published: June 2021

Chronic obstructive pulmonary disease (COPD) is the fourth major cause of mortality and morbidity worldwide and is projected to be the third by 2030. However, there is little evidence available on the associations of COPD hospitalizations with meteorological factors and air pollutants in developing countries/regions of Asia. In particular, no study has been done in western areas of China considering the nonlinear and lagged effects simultaneously. This study aims to evaluate the nonlinear and lagged associations of COPD hospitalizations with meteorological factors and air pollutants using time-series analysis. The modified associations by sex and age were also investigated. The distributed lag nonlinear model was used to establish the association of daily COPD hospitalizations of all 441 public hospitals in Chengdu, China from Jan/2015–Dec/2017 with the ambient meteorological factors and air pollutants. Model parameters were optimized based on quasi Akaike Information Criterion and model diagnostics was conducted by inspecting the deviance residuals. Subgroup analysis by sex and age was also performed. Temperature, relative humidity, wind and Carbon Monoxide (CO) have statistically significant and consistent associations with COPD hospitalizations. The cumulative relative risk (RR) was lowest at a temperature of 19℃ (relative humidity of 67%). Both extremely high and low temperature (and relative humidity) increase the cumulative RR. An increase of wind speed above 4 mph (an increase of CO above 1.44 mg/m3) significantly decreases (increases) the cumulative RR. Female populations were more sensitive to low temperature and high CO level; elderly (74+) populations are more sensitive to high relative humidity; younger populations (< = 74) are more susceptible to CO higher than 1.44 mg/m3. Therefore, people with COPD should avoid exposure to adverse environmental conditions of extreme temperatures and relative humidity, low wind speed and high CO level, especially for female and elderly patients who were more sensitive to extreme temperatures and relative humidity.
Plasma lipidomic analysis shows a disease progression signature in mdx mice
Authors: Tsonaka Roula , Seyer Alexandre , Aartsma-Rus Annemieke , Spitali Pietro
Published: June 2021

Duchenne muscular dystrophy (DMD) is a rare genetic disorder affecting paediatric patients. The disease course is characterized by loss of muscle mass, which is rapidly substituted by fibrotic and adipose tissue. Clinical and preclinical models have clarified the processes leading to muscle damage and myofiber degeneration. Analysis of the fat component is however emerging as more evidence shows how muscle fat fraction is associated with patient performance and prognosis. In this article we aimed to study whether alterations exist in the composition of lipids in plasma samples obtained from mouse models. Analysis of plasma samples was performed in 4 mouse models of DMD and wild-type mice by LC–MS. Longitudinal samplings of individual mice covering an observational period of 7 months were obtained to cover the different phases of the disease. We report clear elevation of glycerolipids and glycerophospholipids families in dystrophic mice compared to healthy mice. Triacylglycerols were the strongest contributors to the signatures in mice. Annotation of individual lipids confirmed the elevation of lipids belonging to these families as strongest discriminants between healthy and dystrophic mice. A few sphingolipids (such as ganglioside GM2, sphingomyelin and ceramide), sterol lipids (such as cholesteryl oleate and cholesteryl arachidonate) and a fatty acyl (stearic acid) were also found to be affected in dystrophic mice. Analysis of serum and plasma samples show how several lipids are affected in dystrophic mice affected by muscular dystrophy. This study sets the basis to further investigations to understand how the lipid signature relates to the disease biology and muscle performance.
Facile proton-coupled electron transfer enabled by coordination-induced E–H bond weakening to boron
Authors: Wong Anthony , Chakraborty Arunavo , Bawari Deependra , Wu Guang , Dobrovetsky Roman , Ménard Gabriel
Published: June 2021

Coordination induced bond weakening (CIBW) leads to facile PCET at various E–H bonds.
Photomechanical response of sulfonylhydrazone molecular crystals
Authors: Hazarika Pragyan J. , Gupta Poonam , Gunnam Anilkumar , Allu Suryanarayana , Nangia Ashwini K. , Nath Naba K.
Published: June 2021

Photomechanical responses of the single crystals of a series of sulfonylhydrazones are explored for the first time.
Discriminatory behavior of a rhodamine 6G decorated mesoporous silica based multiple cation sensor towards Cu2+ and Hg2+vis-à-vis Al3+, Cr3+ and Fe3+: selective removal of Cu2+ and Hg2+ from aqueous media
Authors: Singha Debdas , Pal Ananya , Uyama Hiroshi , Roy Partha , Nandi Mahasweta
Published: June 2021

A rhodamine incorporated silica material (R6FMS) detects Al3+, Cr3+, Fe3+ and Cu2+ in ethanol whereas in aqueous media it can sense as well as separate Cu2+ and Hg2+ ions.
N-Heterocyclic silylenes in coinage metal chemistry: an account of recent advances
Authors: Ghosh Moushakhi , Khan Shabana
Published: June 2021

This review summarizes the recent developments in the field of silylene–coinage metal chemistry.
Microfluidic chip grafted with integrin tension sensors for evaluating the effects of flowing shear stress and ROCK inhibitor on platelets
Authors: Mao Subin , Sarkar Anwesha , Wang Yongliang , Song Chao , LeVine Dana , Wang Xuefeng , Que Long
Published: June 2021

Integrins are key players in platelet adhesion and aggregation.
Chlorinated metabolites from Streptomyces sp. highlight the role of biosynthetic mosaics and superclusters in the evolution of chemical diversity
Authors: Morshed Mahmud T. , Lacey Ernest , Vuong Daniel , Lacey Alastair E. , Lean Soo Sum , Moggach Stephen A. , Karuso Peter , Chooi Yit-Heng , Booth Thomas J. , Piggott Andrew M.
Published: June 2021

Biosynthetic mosaics and superclusters provide rare insights into the evolution of microbial chemical diversity.
Quick extracellular biosynthesis of low-cadmium ZnxCd1−xS quantum dots with full-visible-region tuneable high fluorescence and its application potential assessment in cell imaging
Authors: Qi Shiyue , Chen Ji , Bai Xianwei , Miao Yahui , Yang Shuhui , Qian Can , Wu Borong , Li Yanjun , Xin Baoping
Published: June 2021

The biosynthesis of metal nanoparticles/QDs has been universally recognized as environmentally sound and energy-saving, generating less pollution and having good biocompatibility, which is most needed in biological and medical fields.
The effects of protein charge patterning on complex coacervation
Authors: Zervoudis Nicholas A. , Obermeyer Allie C.
Published: June 2021

Charge patterned polypeptides modulate the complex coacervation of globular proteins with polymers. These protein coacervates have applications in protein encapsulation and delivery and in determining the function of biomolecular condensates.
Regulating the morphology and size of homopolypeptide self-assembliesviaselective solvents
Authors: Shu Wenchao , Liu Zhen , Xie Yangchun , Shi Xinjie , Qi Shuo , Xu Min , He Xiaohua
Published: June 2021

Rod-like micelles including spindles and cylinders with controlling length can be prepared by a solution self-assembly of poly(γ-benzyl-l-glutamate) homopolypeptides with a terminal pyrene group (Py-PBLG) in the selective cosolvents.
Sandwich hydrogel with confined plasmonic Cu/carbon cells for efficient solar water purification
Authors: Tian Cheng , Li Chengcheng , Chen Delun , Li Yifan , Xing Lei , Tian Xinlong , Cao Yang , Huang Wei , Liu Zhongxin , Shen Yijun
Published: June 2021

A sandwich hydrogel evaporator is obtained by confining plasmonic Cu/carbon cell solar absorbers in the evaporation surface of a PVA hydrogel to achieve high-efficiency solar water purification.
In situ growth of MOF-derived ultrafine molybdenum carbide nanoparticles supported on Ni foam as efficient hydrogen-evolution electrocatalysts
Authors: Lv Yanlong , Gong Jian Ru
Published: June 2021

The in situ growth of Mo-containing MOFs on nickel foam was achieved through the conversion of CoMo hydroxide/oxide nanosheets. After pyrolysis, ultrafine MoxC nanoparticles were encapsulated in carbon with sufficient active sites and protection.
A review of the thermophysical properties and potential of ionic liquids for thermal applications
Authors: Fabre Elaine , Murshed S M Sohel
Published: June 2021

Key thermophysical properties of ILs were evaluated and compared leading to their classification by thermal conductivity and viscosity behavior into groups according to their cation types and also providing insights for their thermal applications.
Fluorescent nanodiamonds encapsulated by Cowpea Chlorotic Mottle Virus (CCMV) proteins for intracellular 3D-trajectory analysis
Authors: Wu Yingke , Cao Shuqin , Alam Md Noor A , Raabe Marco , Michel-Souzy Sandra , Wang Zuyuan , Wagner Manfred , Ermakova Anna , Cornelissen Jeroen J. L. M. , Weil Tanja
Published: June 2021

Fluorescent nanodiamonds are stabilized by a corona of virus capsid proteins. Intracellular diffusion studies were performed suggesting that virus-coated nanodiamonds could be attractive tools for conceptual understanding of cell-virus interactions.
Flexible thermosensitive films based on shallow-trap persistent luminescence for high-resolution texture imaging of fingerprints even through latex gloves
Authors: Zheng Shenghui , Shi Junpeng , Wang Xiaodan , Fu Xiaoyan , Fan Hongyong , Zhang Hongwu
Published: June 2021

A flexible film embedded with a thermosensitive shallow-trap persistent luminescence material enables sensitive temperature sensing and exhibits excellent fingerprint imaging.
Accuracy Assessment of Two Electromagnetic Articulographs: Northern Digital Inc. WAVE and Northern Digital Inc. VOX
Authors: Rebernik Teja , Jacobi Jidde , Tiede Mark , Wieling Martijn
Published: June 2021

Purpose

This study compares two electromagnetic articulographs manufactured by Northern Digital, Inc.: the NDI Wave System (from 2008) and the NDI Vox-EMA System (from 2020).

Method

Four experiments were completed: (a) comparison of statically positioned sensors, (b) tracking dynamic movements of sensors manipulated using a motor-driven LEGO apparatus, (c) tracking small and large movements of sensors mounted in a rigid bar manipulated by hand, and (d) tracking movements of sensors rotated on a circular disc. We assessed spatial variability for statically positioned sensors, variability in the transduced Euclidean distances between sensor pairs, and missing data rates. For sensors tracking circular movements, we compared the fit between fitted ideal circles and actual trajectories.

Results

The average sensor pair tracking error (i.e., the standard deviation of the Euclidean distances) was 1.37 mm for the WAVE and 0.12 mm for the VOX during automated trials at the fastest speed, and 0.35 mm for the WAVE and 0.14 mm for the VOX during the tracking of large manual movements. The average standard deviation of the fitted circle radii charted by manual circular disc movements was 0.72 mm for the WAVE sensors and 0.14 mm for the VOX sensors. There was no significant difference between the WAVE and the VOX in the number of missing frames.

Conclusions

In general, the VOX system significantly outperformed the WAVE on measures of both static precision and dynamic accuracy (automated and manual). For both systems, positional precision and spatial variability were influenced by the sensors' position relative to the field generator unit (worse when further away).

Supplemental Material

https://doi.org/10.23641/asha.14787846
Investigating the delay between dust radiation and star-formation in local and distant quenching galaxies
Authors: Ciesla L. , Buat V. , Boquien M. , Boselli A. , Elbaz D. , Aufort G.
Published: June 2021

We investigate the timescale over which the infrared (IR) luminosity decreases after a complete and rapid quenching of star formation using observations of local and high-redshift galaxies. From spectral energy distribution modelling, we derive the time since quenching of a subsample of 14 galaxies from the Herschel Reference Survey that suffer from ram-pressure stripping due to the environment of the Virgo cluster and of a subsample of 7 rapidly quenched COSMOS galaxies selected through a state-of-the-art statistical method already tested on the determination of galaxy star formation history (SFH). Three out of the seven COSMOS galaxies have an optical spectrum with no emission line, confirming their quenched nature. We obtained the present physical properties of the combined sample (local plus high-redshift) from the long-term SFH properties, as well as the past LIR of these galaxies just before their quenching. We show that this past LIR is consistent with the LIR of reference samples of normally star-forming galaxies with same stellar mass and redshift as each of our quenched galaxies. We put constraints on the present to past IR luminosity ratio as a function of quenching time. The two samples probe different dynamical ranges in terms of quenching age with the HRS galaxies exhibiting longer timescales (0.2–3 Gyr) compared to the COSMOS ones (< 100 Myr). Assuming an exponential decrease in the LIR after quenching, the COSMOS quenched galaxies are consistent with short e-folding times of less than a couple of hundred million years, while the properties of the HRS quenched galaxies are compatible with larger timescales of several hundred million years. For the HRS sample, this result is consistent with the known quenching mechanism that affected them, namely ram pressure stripping due to the environment. For the COSMOS sample, different quenching processes are acting on short to intermediate timescales. Processes such as galaxy mergers, disk instabilities, and environmental effects can produce such strong star formation variability.
NGC 1261: An r-process enhanced globular cluster from the Gaia-Enceladus event
Authors: Koch-Hansen Andreas J. , Hansen Camilla J. , McWilliam Andrew
Published: June 2021

Our Milky Way (MW) has witnessed a series of major accretion events in the past. One of the later additions, the Gaia-Enceladus merger, has contributed a considerable mass to the inner Galaxy, but also generously donated to the outer halo. So far, associations with present-day MW globular clusters (GCs) have been chiefly based on their kinematics and ages. In this work, we present a chemical abundance study of the outer halo (RGC ∼ 18 kpc) GC NGC 1261, which has been suggested to be an accreted object based on its younger age. We measured 31 species of 29 elements in two stars from high-resolution Magellan/MIKE spectra and find that the cluster is moderately metal poor, at [Fe/H] = −1.26, with a low scatter of 0.02 dex. NGC 1261 is moderately α-enhanced to the 0.3 dex level. While from the small sample alone it is difficult to assert any abundance correlations, the light elements Na, O, Mg, and Al differ significantly between the two stars in contrast to the majority of other elements with smaller scatter; this argues in favor of multiple generations of stars coexisting in this GC. Intriguingly for its metallicity, NGC 1261 shows heavy element abundances that are consistent with r-process nucleosynthesis and we discuss their origin in various sites. In particular the Eu overabundance quantitatively suggests that one single r-process event, such as a neutron-star neutron-star merger or a rare kind of supernova, can be responsible for the stellar enhancement or even the enrichment of the cluster with the excess r material. Its heavy element pattern makes NGC 1261 resemble the moderately enhanced r-I stars that are commonly found in the halo and have been detected in Gaia-Enceladus as well. Therefore, combining all kinematical, age, and chemical evidence we conclude that NGC 1261 is a chemically intriguing GC that was born in the Gaia-Enceladus galaxy and has been subsequently accreted into the MW halo.
Portfolio Construction of Energy-Related Assets
Authors: Feng Yifei , Li Kexin , Wang Yingxuan
Published: June 2021

Portfolio construction is one of the most fatal issues of modern finance, which can effectively gain returns or reduce risks. This study constructs portfolios in energy-related assets. Specifically, the Monte Carlo simulations are carried out for a hundred thousand times in order to discover the efficient frontier and find the minimum variance and the maximum sharp ratio portfolio. According to the simulations, the American Electric Power possesses the largest share in minimum variance portfolio, while NextEra Energy for sharp ratio method. The results may benefit certain investor in financial markets and shed lights to focus more on portfolio allocation during constructing.
Research on subsidy mechanism in the government-led agricultural supply chain finance
Authors: Lu Qi Hui , Xu Tingting
Published: June 2021

The problem of difficult and expensive financing of credit funds restricts the development of agriculture in our country. The government adopts different measures to support and guide the sustainable development of agriculture, there are typical loan interest subsidy mechanism. Under the background of agricultural output is uncertain, a supply chain system composed of farmer, company, bank and the government has been established, it discusses the government subsidy for agricultural supply chain operation and the influence of the members of the decision-making, explores the differences between two kinds of mechanism and provides suggestions for the decision of the supply chain members. Studies have shown that in the context of government subsidy, when the random output factor is higher and the loan interest rate is lower, the higher the loan interest subsidy rate, the higher the profit and social welfare of farmer, company, and bank. When the bank interest rate is higher than a certain value, the government subsidy can increase the profits of farmer and bank. Finally, numerical simulation found that in the context of government subsidy, government subsidy reduces the financing cost of farmer, but the real beneficiary is bank.
Comparative study on strategic modes of e-commerce platform between Jingdong and Alibaba
Authors: Fan Dijun , Li Xufang , Zhang Jinmin
Published: June 2021

Based on the literature research, this paper collects and reads the theoretical literature related to strategic models and tries to find out the common points and shortcomings of the strategic models of the two major e-commerce platforms, Jingdong and Alibaba, in the process of development, and mainly conducts a comparative study on the logistics strategies and competitive strategies of Alibaba and Jingdong. Through the research and analysis, it is hoped that the two platforms can build on their strengths and avoid their weaknesses in the development and promote the further optimization of their respective platforms, and also have high reference value for other similar e-commerce platforms.
Financing Dilemma of Minor enterprises in Post-epidemic Era and Its Suggestions-Taking Wuhan City as an Example
Authors: Zhao Chenyi , Wang Junyi
Published: June 2021

Minor enterprises have made an indelible contribution to economic development, while financing has always been a problem hindering the sustainable development of them. Under the influence of the epidemic, the business environment of minor enterprises has changed, and the financing demand has also changed. However, the degree and scope of assistance are limited. There is a contradiction between supply and demand in fund allocation. Based on this, this project puts forward policy suggestions by studying the changes of financing demand and fund supplier of minor enterprises in Wuhan in the post epidemic era, which will help to solve the financing difficulties and promote healthy and sustainable development of the national economy.
The influence of digital economy on the upgrading of industrial structure
Authors: Liu Siyu
Published: June 2021

Digital economy is an important starting point for China’s high-quality economic development, which may have an impact on the level of industrial structure. This paper calculates the development level of digital economy by entropy weight method, selects the relevant data of 31 provinces and cities in China from 2012 to 2019, and uses the method of empirical test to analyze the impact of the development of digital economy on the upgrading of China’s industrial structure. The result shows that the development of digital economy can promote the upgrading of China’s overall industrial structure, which is significant at the level of 1%. Further research shows that the development of digital economy has regional heterogeneity on the upgrading of industrial structure in the eastern, central and western regions of China. The research of this paper has important practical significance for the high-quality development of China’s economy.
Opportunities and challenges faced by private enterprises under the low-carbon economy and countermeasures
Authors: Zhou Lixing
Published: June 2021

In the background of the rapid development of market economy, a large number of carbon dioxide emissions, leads to the obvious imbalance of carbon in nature. In recent years, the global temperature is getting warmer, the sea level is rising year by year, and the grain production is also significantly reduced, which will bring a great threat to the normal survival and development of human beings. In order to protect the environment on which human beings live, low carbon economy is put forward. Under the environment of low carbon economy, private enterprises are not only facing new development opportunities. At the same time, private enterprises are also facing new development challenges. If they want to develop further, they must actively deal with them. The author analyzes the opportunities and challenges faced by private enterprises under the environment of low carbon economy, and puts forward specific countermeasures, hoping to be helpful to the long-term development of private enterprises.
The financing strategy of agricultural supply chain based on cost sharing and buyer guarantee is considered in smart agriculture
Authors: Lu Qi Hui , Tan Qian Hong
Published: June 2021

Supported by the agricultural technology, the intelligent agricultural development is flourishing. However, due to the high technology cost and investment risk, intelligent agriculture in China is still in the exploration stage. This article designs the appropriate cost sharing mechanism under the two-stage supply chain system, which composes of a farmer, a core enterprise and a commercial bank. With the comparison between commercial bank financing model and the buyer guarantees financing model, this paper researches the optimal decisions of supply chain members and the influence of the cost-sharing ratio, technical input gain effect and the buyer guarantees ratio. The results show that the profit will increase with the add of technical input gain effect. Besides, only under certain conditions, cost sharing is valuable to each member. Finally, numerical examples show existing an optimal interest rate spread area that all members would benefit from the buyer guarantee financing model.
Research on the impact of economic growth and technological innovation on carbon emissions from the perspective of space
Authors: Bao Bingwen , Lin Beiqiao
Published: June 2021

As many economic activities have a spatial spillover effect on carbon emissions, this paper selects the data of various provinces and cities from 2003 to 2017 to construct a spatial vector autoregressive model to analyze and study the effects of economic growth and technological innovation on carbon emissions from a spatial perspective. The results of the study found that carbon emissions, economic growth, and technological innovation generally showed positive response characteristics after being impacted by each other in time, but they weakened over time. In space, carbon emissions will also increase with geographic distance, and the response received will continue to weaken.
Decomposition and Decoupling Analysis of Industrial Solid Waste in the Yangtze River Economic Belt
Authors: Teli Ma
Published: June 2021

In this paper, LMDI method is used to analyze the driving factors of industrial solid waste production in the Yangtze River Economic Belt from 2005 to 2018, and the decoupling state is analyzed by Tapio indicator. We found that:①Industrial pollution intensity effect and industrial structure effect inhibited industrial solid waste production, while regional output effect and population size effect played a role in increasing the pollution; ②in different periods, the decoupling states of industrial solid waste in the Yangtze River Economic Belt were weak decoupling, weak decoupling and expansive negative decoupling. The decoupling indicator showed a trend of first decreasing and then increasing. It is suggested to guide investment to environment-friendly industries and strengthen the research on solid waste reduction technology.
Opportunities and Challenges of China’s Low-Carbon Economic Development in the New Era
Authors: Chen Zhang , Yixuan Tong
Published: June 2021

In the context of the increasingly severe global greenhouse effect, the “14th Five-Year Plan” proposes to “promote green development and promote harmonious coexistence between man and nature”, which provides a new platform for the faster and better development of low-carbon countries. The low-carbon economy has entered a high-quality stage of China’s economic development in the new era, which is of great significance to the overall green transformation of China’s economic and social development. In order to assess the development level of China’s low-carbon economy, this paper estimates the carbon emissions and carbon emission intensity of energy consumption from 2008 to 2017 and applies the LMDI model to decompose the influencing factors of carbon emissions, analyzes the contribution rate of driving factors, and proposes energy saving, emission reduction and low carbon. Developmental countermeasures. The results show that economic growth and energy intensity are the biggest driving factors for promoting and suppressing carbon emissions, respectively. Measures are taken to improve energy structure, increase utilization efficiency, develop low-carbon industries, and promote low-carbon life.
Study on the Influence of CFO Characteristics on Accounting Conservatism of Listed Companies
Authors: Yu Miao
Published: June 2021

As the information reflection of social economy, the quality of accounting information is closely related to economic development and market operation system. And accounting conservatism is one of the important standards to measure of quality of accounting information. As the maker and executor of the financial strategy of the listed company, the CFO’s different personal characteristics will affect its choice of different accounting policies, thus affecting the accounting conservatism of the enterprise. Therefore, this paper selects CFOs of A-share listed companies in Shanghai and Shenzhen from 2016 to 2018 as research objects, respectively discusses the influence of CFO’s natural attributes and social attributes on accounting conservatism, and analyzes the moderating effect of property rights and CFO’s power on the relationship between them. The results show that the CFO’s age, tenure, education, professional skills, salary and number of part-time jobs are negatively correlated with accounting conservatism. The female CFO, shareholding and concurrent director are significantly positively correlated with accounting conservatism. The difference of property right nature and CFO power moderates the relationship between CFO characteristics and accounting conservatism to some extent. On this basis, this paper puts forward corresponding suggestions on how to improve accounting conservatism and promote economic development.
Management Decision and Dual Innovation
Authors: Liu Liangcan , Li Ruowei , Guo Wenming
Published: June 2021

China’s economic development is strongly constrained by existing resources, and the implementation of low-carbon economy and sustainable development requires enterprises to improve their Innovation and R&D capability. As an important participant in the decision-making and execution of the company, the managerial discretion of top managers is related to the overall direction of the organization Taking Shanghai and Shenzhen A-share listed companies from 2009 to 2020 as the research objects, this paper empirically studies the choice of managerial discretion on enterprise innovation mode, and constructs the mediation model of corporate governance level. The results show that the promotion of executive decision-making power can increase the investment in exploratory innovation but weaken exploitative innovation, and the level of corporate governance plays a partial mediating role in the influence of managerial discretion on exploratory innovation. This paper elaborates the research on the influence of managerial discretion on enterprise innovation mode, which is helpful for enterprises to adjust the size of managerial discretion according to their actual needs, pay attention to the level of corporate governance, and make enterprises better control the choice of dual innovation.
Research on University-enterprise Cooperation Practical Education of New Engineering Majors under the Background of Integration of Industry and Education
Authors: Feng Pengfei , Jin Huiqing , Lu Mingyu , Wang Jiangbo , Zhang Shulun , Pan Tao
Published: June 2021

With the implementation of the national strategy of “transportation power”, the transportation major is facing the transformation of new engineering majors. Practical education is an important link in the training of new engineering majors in application-oriented universities and plays a vital role in the quality of talent training. The transformation and upgrading of traditional majors has promoted the transformation of traditional school-enterprise cooperation to the integration of industry and education. Under the background of the integration of industry and education, the author puts forward some viewpoints, such as the precise orientation of talent training, the improvement of the system construction of practical education base, and the broadening of the practical education forms of the integration of industry and education. Taking Anhui Sanlian University as an example, This paper analyzes the practice and achievement of university-enterprise cooperative practical education construction for new engineering majors under the background of the integration of industry and education.
Practice and Reflection on the Application of Blockchain Technology in the Guangdong-Hong Kong-Macao Greater Bay Area
Authors: Liao Qian , Zeng LiJuan
Published: June 2021

Blockchain technology has now entered the 3.0 era with solutions of“Blockchain Plus Industry”. As a technological innovation and industry-leading region, the Guangdong-Hong Kong-Macao Greater Bay area has inherent advantages in the development of blockchain technology. How blockchain can lead the development of industry ecology in the future is a question worthy of our in-depth discussion. By analyzing the policy support and basic status of the Guangdong-Hong Kong-Macao Greater Bay Area, this paper sorted out the structure of the four-level characteristic development mode of blockchain technology, summarized the impossible triangle of technology, incompatibility issues, standard construction, supervision and other issues, and putforward relevant suggestions for the development of the blockchain in the Guangdong-Hong Kong-Macao Greater Bay area.
Exploratory Study on Family Leisure Constraints of the Twochild Family in China
Authors: Zhang Caihong , Xu Qiuya , Zhu Li
Published: June 2021

Driven by the two-child policy, there are more and more two-child families in China. The purpose of this research was to examine the leisure constraints of these families in Chinese urban areas. Based on interviews with the parents from 12 families and the leisure constraint theory, the main factors are identified. First, intrapersonal constraints, which include personal physical constraints (such as insufficient postpartum recovery) and psychological constraints(such as stress). Second, interpersonal constraints, which mainly come from family members (such as family support) and friends (such as narrowing social circles). Third, structural constraints, like family income, climate conditions, facilities, free time for leisure. Besides, the study also discovered a new type of constraint-cultural constraints, which is embodied in familism. This factor is close to the other three constraints and affects them. Based on this, the research proposed a new hierarchical model of leisure constraints. Finally, the article puts forward some suggestions for future research on family leisure under the influence of the two-child policy.
Endoscopic band ligation in the treatment of gastric antral vascular ectasia: a systematic review and meta-analysis
Authors: McCarty Thomas R. , Hathorn Kelly E. , Chan Walter W. , Jajoo Kunal
Published: June 2021

Background and study aims While argon plasma coagulation (APC) is the first-line treatment for gastric antral vascular ectasia (GAVE), endoscopic band ligation (EBL) has shown promising results. The aim of this study was to perform a systematic review and meta-analysis to evaluate the effectiveness of EBL for the treatment of GAVE.

Methods Individualized search strategies were developed in accordance with PRISMA and MOOSE guidelines through September 1, 2020. Measured outcomes included endoscopic success (defined as GAVE eradication/improvement), change in hemoglobin, transfusion dependency, number of treatment sessions, adverse events, rebleeding, and bleeding-associated mortality. Outcomes were compared among studies evaluating EBL versus APC.

Results Eleven studies (n = 393; 59.39 % female; mean age 58.65 ± 8.85 years) were included. Endoscopic success was achieved in 87.84 % [(95 % CI, 80.25 to 92.78); I2 = 11.96 %] with a mean number of 2.50 ± 0.49 treatment sessions and average of 12.40 ± 3.82 bands applied. For 8 studies comparing EBL (n = 143) versus APC (n = 174), there was no difference in baseline patient characteristics. However, endoscopic success was significantly higher for EBL [OR 6.04 (95 % CI 1.97 to 18.56; P = 0.002], requiring fewer treatment sessions (2.56 ± 0.81 versus 3.78 ± 1.17; P < 0.001). EBL was also associated with a greater increase in post-procedure hemoglobin [mean difference 0.35 (95 % CI 0.07 to 0.62; P = 0.0140], greater reduction in transfusions required [mean difference –1.46 (95 % CI –2.80 to –0.12; P = 0.033], and fewer rebleeding events [OR 0.11 (95 % CI, 0.04 to 0.36); P < 0.001]. There was no difference in adverse events or bleeding-associated mortality (P > 0.050).

Conclusions EBL appears to be safe and effective for treatment of GAVE, with improved outcomes when compared to APC.
Effect of Adrenocorticotropic Hormone Stimulation During Simultaneous
Bilateral Adrenal Vein Sampling in Primary Aldosteronism
Authors: Liu Wei , Zhang Jingjing , Yang Yaling , Jin Yinxin , Li Zaizhao , You Liting , Luo Jianguang , Su Xin
Published: June 2021

The aim of the study was to investigate the significance and influence of
adrenocorticotropic hormone (ACTH) stimulation in primary aldosteronism (PA)
patients with simultaneous bilateral adrenal vein sampling (AVS). All patients
diagnosed with PA underwent simultaneous bilateral AVS with ACTH. In 95
patients, the post-ACTH SI significantly increased (p<0.001), and it
gradually decreased from t10–t30 after ACTH stimulation
(p<0.001). The unsuccessful catheterization decreased after ACTH
stimulation. Time points within 20 min after ACTH stimulation were better for
sampling, and the selectivity did not increase over longer periods. According to
lateralization before and after ACTH stimulation, the patients could be divided
into 3 groups (U, unilateral; B, bilateral): U/U , U/B or
B/U, and B/B. Compared with the U/U group, in the
U/B or B/U and B/B groups, the lateralization index (LI)
was lower both at baseline and after ACTH stimulation (p<0.0001), the
contralateral index (CLI) was higher after ACTH stimulation (p<0.003),
the serum potassium level was higher (p<0.001), and the carbon dioxide
combining power (CO2CP) and base excess (BE) levels were lower. In conclusion,
in simultaneous bilateral AVS, ACTH stimulation had significant effects on
increasing the catheterization selectivity. Lateralization change was observed
after stimulation. After ACTH stimulation, fewer patients could be diagnosed
with lateralized PA. Patients with consistent lateralized PA showed a more
serious phenotype.
A GLP-1 Receptor Agonist Inhibits Aldosterone Release in Healthy
Volunteers
Authors: Sedman Tuuli , Volke Vallo , Heinla Keiu , Vasar Eero
Published: June 2021

Glucagon-like peptide 1 receptor agonists (GLP-1 RAs) are antidiabetic drugs with
effects beyond antihyperglycemic action. The aim of the study was to examine
whether a single dose of exenatide could be used as a stimulation test for the
pituitary-adrenal axis. We carried out a single-group, open-label pilot clinical
trial in an ambulatory setting. Ten healthy volunteers of both sexes with body
weight>65 kg and age between 18–50 years were recruited.
After fasting for 12 hours the subjects received 10 μg of
exenatide solution subcutaneously. Blood samples were taken before the
administration of exenatide and up to 150 minutes thereafter. The primary
outcome was the maximal level of cortisol after the administration of exenatide.
Single administration of exenatide 10 μg resulted in a modest
increase in ACTH and cortisol levels, as compared to untreated values, and a
decrease in blood glucose levels. Remarkably, a robust suppression of both renin
and aldosterone levels occurred. We showed that acute administration of
exenatide in a full therapeutic dose modestly stimulates the
hypothalamic-pituitary-adrenal axis but inhibits the renin-aldosterone system.
Further research is warranted to confirm this finding in the placebo-controlled
study.
Recent Applications of the Diels–Alder Reaction in the Synthesis of Natural Products (2017–2020)
Authors: Sara Alexandru A. , Um-e-Farwa Um-e-Farwa , Saeed Aamer , Kalesse Markus
Published: June 2021

The Diels–Alder reaction has long been established as an extremely useful procedure in the toolbox of natural product chemists. It tolerates a wide spectrum of building blocks of different complexity and degrees of derivatization, and enables the formation of six-membered rings with well-defined stereochemistry. In recent years, many total syntheses of natural products have been reported that rely, at some point, on the use of a [4+2]-cycloaddition step. Among classic approaches, several modifications of the Diels–Alder reaction, such as hetero-Diels–Alder reactions, dehydro-Diels–Alder reactions and domino-Diels–Alder reactions, have been employed to extend the scope of this process in the synthesis of natural products. Our short review covers applications of the Diels–Alder reaction in natural product syntheses between 2017 and 2020, as well as selected methodologies which are inspired by, or that can be used to access natural products.

1 Introduction

2 Syntheses from 2017

3 Syntheses from 2018

4 Syntheses from 2019

5 Syntheses from 2020

6 Conclusion
Cardiovascular Oncology: The Need for a Multidisciplinary Approach
Authors: Ortega Pérez Rodrigo , Pardo Sanz Ana , García Gutiérrez Valentín , Zamorano Gómez José Luis
Published: June 2021

Improved cancer survivorship has led to an increase in cardiovascular (CV) complications in the oncologic population, mainly associated with therapeutic regimens. Hence, cardio-oncology has grown toward unifying the cancer care process in which the best prevention, early detection, treatment, and CV surveillance are offered to patients. This multidisciplinary approach allows us to optimize and agree upon clinical decisions to enhance clinical outcomes. Atrial fibrillation is one of the hot topics in the field because it is still challenging in cancer patients. The optimal antithrombotic therapy remains unclear. Nevertheless, evidence supports that specific recommendations are needed due to a hemorrhagic/thrombotic disbalance present within this subgroup of patients and a low rate of anticoagulation treatments compared with the general population. Further, cardiotoxicity management is currently transforming. Increasingly, early detection of subclinical alterations is raising awareness. When medical therapy is initiated early, fewer patients progress to ventricular dysfunction and the rate of patients completing cancer therapy gradually increases. New approaches are demonstrating better outcomes and these strategies will expectedly be established in clinical practice. Cardio-oncology enables us to find the best balance between cancer treatment and CV health protection. Nowadays, more and more physicians are being instructed in this discipline, which gradually exhibits a greater presence in conferences and scientific journals. However, given the need for physicians thoroughly trained in cardio-oncology, this subspecialty must be promoted further.
Digital-micromirror-device-based surface measurement using heterodyne interferometry with optical frequency comb
Authors: Xu Guangyao , Wang Yue , Xiong Shilin , Wu Guanhao
Published: June 2021

We propose a surface measurement method based on optical frequency comb heterodyne interferometry ranging. A digital micromirror device is used to establish a single-pixel detection system without a mechanical scanning device and realize high-speed sampling. The measurement range of the step height is extended by synthetic wavelength interferometry from half of the carrier wavelength to half of the synthetic wavelength (40 μm in this system). Thus, a sample composed of three gauge blocks and an MEMS device of the teardrop-shaped groove were measured with an accuracy of 5 nm and a measurement time of 27 ms.
A bioimpedance spectroscopy technique to monitor bioprocess involving complex growth micro-organisms
Authors: Salvino da Silva Marcos Antonio , Sanches Elizabeth Gomes , Pereira Nei , Nogueira de Souza Marcio , Pino Alexandre Visintainer
Published: June 2021

Although analytical methods (often offline) are considered as references (gold standards) for monitoring industrial bioprocesses, real-time monitoring (online) is always preferable for maximizing such processes. However, many of the real-time methods that measure total cell concentration cannot distinguish living micro-organisms from the dead ones or even other materials. Moreover, some real-time methods also lead to possible wrong results when the micro-organism involved in the bioprocess exhibits significant metabolic, physiological, and kinetic changes as it grows. This study presents a real-time technique intended to monitor this class of micro-organisms and that is based on an alternative method of bioimpedance spectroscopy. The feasibility of the proposed technique was evaluated during bacterial growth experiments using the bacteria Bacillus thuringiensis var. israelensis (Bti) with initial inocula of 5%, 10%, and 15% (v/v on 220 ml). Each growth experiment was monitored every hour over 18 h by the proposed technique and by a classical offline method (McFarland method). The results of monitoring the studied bioprocess by both methods exhibited an average Pearson correlation coefficient (r̄) of above 0.9 and good agreement when the Bland–Altman method was used to compare them.
Improving half-projected spin-contaminated wave functions by multi-configuration perturbation theory
Authors: Mihálka Zsuzsanna É. , Szabados Ágnes , Surján Péter R.
Published: June 2021

Allowing triplet components of individual geminals, spin-contaminated strongly orthogonal geminal wave functions may emerge, which can be ameliorated by spin-projection techniques. Of the latter, half-projection was previously shown to be useful, offering a compromise between the amount of remaining spin-contamination and the violation of size consistency generated by projection. This paper investigates how a half-projected spin-contaminated geminal wave function can be improved by multi-configuration perturbation theory to incorporate dynamical correlation effects.
Theory, simulation, fabrication, and characterization of Galois scattering plates for the optical and the THz spectral range
Authors: Fouckhardt Henning , Doering Christoph , Jaax Michael , Laegel Bert
Published: June 2021

Scattering and scattering plates have a large diversity of applications. Scattering of optical and THz electromagnetic waves can be performed with Galois scattering plates, which had found applications in acoustics first (i.e., with sound waves in concert hall acoustics). For binary Galois scattering plates, the single scattering entities, i.e., mesas (for a binary 1) or voids (for a binary 0), have characteristic lateral dimensions of half the wavelength of the electromagnetic waves to be scattered. Their optimal height is a quarter of the wavelength for plates used in reflection. Meanwhile, not too elaborate lithographic techniques allow for the implementation of Galois plates for the THz range and even for the visible spectral range. We had reported on such scattering plates before. However, in this paper, also the mathematical concept is described and the fabrication technologies are emphasized. In contrast to the case of scattering plates with irregular surface morphologies, Galois plate scattering is not diffuse, but there are many scattering/diffraction orders.
Impact of the channel length on molybdenum disulfide field effect transistors with hafnia-based high-k dielectric gate
Authors: Sun Yanxiao , Niu Gang , Ren Wei , Zhao Jinyan , Wang Yankun , Wu Heping , Jiang Luyue , Dai Liyan , Xie Ya-Hong , Rojo Romeo Pedro , Bouaziz Jordan , Vilquin Bertrand
Published: June 2021

Field effect transistors (FETs) using two-dimensional molybdenum disulfide (MoS2) as the channel material has been considered one of the most potential candidates for future complementary metal-oxide-semiconductor technology with low power consumption. However, the understanding of the correlation between the device performance and material properties, particularly for devices with scaling-down channel lengths, is still insufficient. We report in this paper back-gate FETs with chemical-vapor-deposition grown and transferred MoS2 and Zr doped HfO2 ((Hf,Zr)O2, HZO) high-k dielectric gates with channel lengths ranging from 10 to 30 µm with a step of 5 µm. It has been demonstrated that channels with the length to width ratio of 0.2 lead to the most superior performance of the FETs. The MoS2/HZO hybrid FETs show a stable threshold voltage of ∼1.5 V, current on/off ratio of >104, and field effect mobility in excess of 0.38 cm2 V−1 s−1. The impact of the channel lengths on FET performance is analyzed and discussed in depth. A hysteresis loop has been observed in the Ids − Vgs characteristics of the hybrid FETs, which has been further studied and attributed to the charge effect at the interfaces. The HZO films show a relatively weak ferroelectric orthorhombic phase and thus serve mainly as the high-k dielectric gate. Charge trapping in the HZO layer that might induce hysteresis has been discussed. Our results show that MoS2/HZO hybrid FETs possess great potential in future low power and high-speed integrated circuits, and future work will focus on further improvement of the transistor performances using ferroelectric HZO films and the study of devices with even shorter MoS2 channels.