bluuebunny/crossref_metadata_2025 huggingface dataset:
Between Inhabited Interiors and Interiors on Display: Exploring Spatial Boundaries at Rosenborg Castle
Authors: Pilegaard Ane
Published: August 2021

When visiting museums, we meet various types of physical barriers, such as glass vitrines, railings, and extended ropes, which have been put there to protect the objects on display. Such barriers are often accused of creating an unfavourable distance to museum objects but can also be thought of in more positive terms, as this article will seek to demonstrate. Based on analyses of museum display boundaries at Rosenborg Castle in Copenhagen, where visitors can experience objects from The Royal Danish Collection within historic interiors, the article looks into the effects of such boundaries on the museum experience. The article explores the particular threshold experiences that take place at Rosenborg where you constantly fluctuate between, on the one side, looking at objects and interiors that have been put on display in front of you, and, on the other, being inside the historic interiors. It argues that this spatial ambiguity opens up productive, albeit obscure, in-between spaces for the museum visitor to inhabit and points to the importance of truly attending to the design of display boundaries when creating museum exhibitions.
Animated Interior
Authors: Atmodiwirjo Paramita , Yatmo Yandi Andri
Published: August 2021

An animated interior represents a departure from the idea of interior space as a permanent and timeless entity. The understanding of animated characters in the interior allows for the emergence of our complex relationship with space through various forms of engagement. The understanding of an animated interior offers further possibilities that become the basis of design practice. This issue of the Interiority journal presents a collection of inquiries and approaches that reveal various animated qualities of the interior in various contexts. The articles address the character of the interior, which is dynamic and dependent upon various temporal conditions of inhabitation. At the same time, they demonstrate the possible design practices that could emerge from the understanding of animated interiors.
NF1 regulates mesenchymal glioblastoma plasticity and aggressiveness through the AP-1 transcription factor FOSL1
Authors: Marques Carolina , Unterkircher Thomas , Kroon Paula , Oldrini Barbara , Izzo Annalisa , Dramaretska Yuliia , Ferrarese Roberto , Kling Eva , Schnell Oliver , Nelander Sven , Wagner Erwin F , Bakiri Latifa , Gargiulo Gaetano , Carro Maria Stella , Squatrito Massimo
Published: August 2021

The molecular basis underlying glioblastoma (GBM) heterogeneity and plasticity is not fully understood. Using transcriptomic data of human patient-derived brain tumor stem cell lines (BTSCs), classified based on GBM-intrinsic signatures, we identify the AP-1 transcription factor FOSL1 as a key regulator of the mesenchymal (MES) subtype. We provide a mechanistic basis to the role of the neurofibromatosis type 1 gene (NF1), a negative regulator of the RAS/MAPK pathway, in GBM mesenchymal transformation through the modulation of FOSL1 expression. Depletion of FOSL1 in NF1-mutant human BTSCs and Kras-mutant mouse neural stem cells results in loss of the mesenchymal gene signature and reduction in stem cell properties and in vivo tumorigenic potential. Our data demonstrate that FOSL1 controls GBM plasticity and aggressiveness in response to NF1 alterations.
Causal neural mechanisms of context-based object recognition
Authors: Wischnewski Miles , Peelen Marius V
Published: August 2021

Objects can be recognized based on their intrinsic features, including shape, color, and texture. In daily life, however, such features are often not clearly visible, for example when objects appear in the periphery, in clutter, or at a distance. Interestingly, object recognition can still be highly accurate under these conditions when objects are seen within their typical scene context. What are the neural mechanisms of context-based object recognition? According to parallel processing accounts, context-based object recognition is supported by the parallel processing of object and scene information in separate pathways. Output of these pathways is then combined in downstream regions, leading to contextual benefits in object recognition. Alternatively, according to feedback accounts, context-based object recognition is supported by (direct or indirect) feedback from scene-selective to object-selective regions. Here, in three pre-registered transcranial magnetic stimulation (TMS) experiments, we tested a key prediction of the feedback hypothesis: that scene-selective cortex causally and selectively supports context-based object recognition before object-selective cortex does. Early visual cortex (EVC), object-selective lateral occipital cortex (LOC), and scene-selective occipital place area (OPA) were stimulated at three time points relative to stimulus onset while participants categorized degraded objects in scenes and intact objects in isolation, in different trials. Results confirmed our predictions: relative to isolated object recognition, context-based object recognition was selectively and causally supported by OPA at 160–200 ms after onset, followed by LOC at 260–300 ms after onset. These results indicate that context-based expectations facilitate object recognition by disambiguating object representations in the visual cortex.
An autonomous framework for interpretation of 3D objects geometric data using 2D images for application in additive manufacturing
Authors: Rezaei Mohammad reza , Houshmand Mahmoud , Fatahi Valilai Omid
Published: August 2021

Additive manufacturing, artificial intelligence and cloud manufacturing are three pillars of the emerging digitized industrial revolution, considered in industry 4.0. The literature shows that in industry 4.0, intelligent cloud based additive manufacturing plays a crucial role. Considering this, few studies have accomplished an integration of the intelligent additive manufacturing and the service oriented manufacturing paradigms. This is due to the lack of prerequisite frameworks to enable this integration. These frameworks should create an autonomous platform for cloud based service composition for additive manufacturing based on customer demands. One of the most important requirements of customer processing in autonomous manufacturing platforms is the interpretation of the product shape; as a result, accurate and automated shape interpretation plays an important role in this integration. Unfortunately despite this fact, accurate shape interpretation has not been a subject of research studies in the additive manufacturing, except limited studies aiming machine level production process. This paper has proposed a framework to interpret shapes, or their informative two dimensional pictures, automatically by decomposing them into simpler shapes which can be categorized easily based on provided training data. To do this, two algorithms which apply a Recurrent Neural Network and a two dimensional Convolutional Neural Network as decomposition and recognition tools respectively are proposed. These two algorithms are integrated and case studies are designed to demonstrate the capabilities of the proposed platform. The results suggest that considering the complex objects which can be decomposed with planes perpendicular to one axis of Cartesian coordination system and parallel withother two, the decomposition algorithm can even give results using an informative 2D image of the object.
Willingness to Adopt the Recommended Practices of Organic Turmeric among Kandhamal Farmers of Odisha
Authors: Panigrahi Asish , Modak Satarupa , Padhy Chitrasena
Published: August 2021

Turmeric Cultivation is one of livelihood for the Kondh tribes of Kandhamal District of Odisha. These farmers were cultivating this crop with their traditional knowledge of crop practices without any intervention of chemical inputs. From the studies, it is found that farmers of the district were economically and educationally backward. Turmeric of Kandhamal is well known for its healing property, color, aroma etc. and received GI tag for its unique features. From the secondary data it was found that there were few public and private extension actors trying to promote organic recommended package of practices for Turmeric.  And, to boost willingness among farmers towards recommended organic Turmeric various socio-economic variables might be responsible. In this view the present study was carried out (2020-21) in Kandhamal district of Odisha to understand attitude towards recommended organic Turmeric and socio-economic variables effecting willingness to adopt organic package of practices of Turmeric. It was found that turmeric growers had medium to high level of willingness to adopt the recommended agricultural practice. And among selected socio-economic variables respondent’s total family member, Members help in family farming and adult male had negative and significantly relationship with willingness to adopt the recommended agricultural practices of organic turmeric. Private extension actors and State Horticulture Department training were continually motivating them to adopt recommended agricultural practices of organic turmeric.
Selectivity of Gillnet to Catch Silver Pomfret (Pampus argenteus) in Pangandaran Waters, Indonesia
Authors: Apriliani Izza Mahdiana , Hamdani Herman , Mulyani Yuniar , Herawati Heti , Simanjorang Dear Frans Lyandre
Published: August 2021

The purpose of this research was to determine the most selective mesh size of gillnet fishing gear for Pampus argenteus in coastal waters of Pangandaran Regency, West Java. Research on the selectivity of gillnet fishing gear was carried out in the coastal waters of Pangandaran, West Java Province, from August 2018 to January 2019. The method used in this research is experimental fishing, namely operating gillnet fishing gear directly in the fishing area with fishermen. The primary data collected was the measurement of the catch (fish weight, number, fork length, how the fish was caught, circumference (girth opercullum, maximum body girth). Meanwhile, the secondary data collected were supporting data from the Pangandaran District Fisheries and Marine Service, and literature study. In determining the sampling, the method used is the purposive sampling method. The operation of gillnets using 4.5 inches obtained a higher proportion of main catch (75%) than gillnets with a mesh size of 5 inches (44%). Gillnet with a mesh size of 4.5 inches, the silver pomfret caught was distributed between 17-22 cm in size with the highest mode in the 19 cm fork length. Unlike the gillnet fishing gear with a mesh size of 5 inches, the silver pomfret caught was distributed in the fork length range of 17-25 cm with the highest mode in the length class 19 cm fork length. mesh size 4.5 inches has a hanging ratio value of 0.51. Meanwhile, the 5 inch mesh size has a hanging ratio value of 0.54. Based on the length distribution, gillnets with a mesh size of 5 inches were more dominant in catching silver pomfret in a larger size class interval than gillnets with a mesh size of 4,5 inches. Based on the L50 value, both selective gillnets caught more fish at 50% second chance. The selectivity curve shows that gillnet fishing gear with a mesh size of 5 inches has more selective results than gillnets with a mesh size of 4.5 inches.
Stomach Content of Tillapia zilli and Oreochromis nilocticus from Wanzun River, Lavun Local Government, Niger State Nigeria
Authors: Mohammed Y. M. , Abubakar M. D. , Muhammad A. M. , Muhammad A. S. , Umar B. L. , Hadizat M. , Achebe A. C.
Published: August 2021

This study was conducted to investigate the stomach contents of two commercially important fish species (Tilapia zilli and Oreochromis nilocticus)  from Wanzun River, Northcentral Nigeria using frequency of occurrence and volumetric methods between January to April 2019. Fish samples were collected monthly with help of Fishermen using various fishing nets and traps. One hundred (100) individual fish of each species were collected and their stomach contents were examined. The results obtained expressed in mean percentage indicated that out of the one hundred (100) individual fish of each species examined,Twelve (12%) fish had an empty stomach contents in Tilapia zilli, and out of the 100 samples examined, Seventeen (17%) fish had an empty stomach content in Oreochromis nilocticus. The stomach contents of both Tilapia zilli and Oreochromis nilocticus consist of detritus, insects, fish remains. Algae/protozoans plant materials and molluscs. Both fish species are omnivorous feeders and occupy the same ecological niche.The study reveals the importance of algae, fish, insects and plant materials as food for fishes and they form important part in the diet of the species examined.
Key Parameters for Healthcare Quality
Authors: Azhar Farah , Ahmad Farah , Anwar Sadaf
Published: August 2021

Over several decades, a wealth of expertise and experience in improving the quality of health care has accrued globally. Despite this wealth of expertise, the challenge that is often faced by country level policymakers in both high- and low-medium income countries is to know which quality policies are being implemented. The goal of this report is to highlight and critically evaluate quality metrics published in the literature for healthcare establishments. Its goal is to present an integrated quality model that combines both technical and supportive quality indicators in order to reach the highest level of patient satisfaction. As some of the priorities of doctors and nurses are to improve patient satisfaction and patient care in a healthcare system Out of all the most critical criterion for evaluating the quality of service offered to the customer by a service provider is customer satisfaction. The quality of patient care and patient satisfaction can be assessed by the quality of facilities and training, the expertise of staff and the reliability of operating processes indicating that if the personal rights and working environment of health workers are not improved, the quality of health care cannot be expected to increase.
Improving Business Pages Recommendation in Social Network Using Link Prediction Methods
Authors: Asaph Watare , Sun Shaowei
Published: August 2021

Recently Social Network has become one of the favorite means for a modern society to perform social interaction and exchange information via the internet. Link prediction is a common problem that has broad application in such social networks, ranging from predicting unobserved interaction to recommending related items. In this paper, we investigate link recommendations over business pages on Facebook Social Network. More specifically, given a company in thenetwork, we want to recommend potential companies to connect with. We start by introducing existing work in link recommendations and some link prediction models as our baseline. We then talk about the Graph Neural Network model SEAL to make a link recommendations in the network. Our results show that SEAL outperformed the compared baseline model while reaching above 94% Area Under Curve accuracy in link recommendations.
Solitary Mastocytoma in Children: Case Report
Authors: Lakhrissi M. , Jabourik F. , Bentahila A.
Published: August 2021

Solitary mastocytoma is the most common form of mastocytosis in children. The main symptom is pruritus. The treatment is symptomatic and it’s based on Topical corticosteroids. The prognosis is good with possibility of spontaneous regression at adulthood. This case report is about a 7-month-old infant that presented with an erythromatous papular lesion on the left temple. The patient responded well to topical steroids and antihistamines.
The Proximate Analysis, Phytochemical Screening, Antioxidant Activity and Mineral Composition of Momordica charantia and Ocimum gratissimum Leaf Powder
Authors: Oloruntola O. D. , Ayodele S. O. , Olowu O. P. A. , Falowo A. B. , Adeyeye S. A. , Omoniyi I. S. , Osowe C. O.
Published: August 2021

Aim: This study aims to evaluate and characterise the Momordica charantia and Ocimum gratissimum leaf powder.

Methodology: The quantitative analyses for proximate, phytochemicals, minerals, and antioxidant activities of Momordica charantia and Ocimum gratissimum leaf powder were carried out using standard procedures.

Results: The result of the proximate analysis showed that both plants contain an appreciable amount of moisture, ash, crude fibre, crude fat, crude protein and nitrogen-free extract content,  with M. charantia leaf powder having higher moisture (5.49 ± 0.03%) content than O. gratissimum leaf powder (5.02 ± 0.01%) (P < 0.05).  Ocimum gratissimum had higher crude fibre content (25.03 ± 0.25%) than M.  charantia leaf powder (20.86 ± 0.12%) (P < 0.05).  The protein, ash, crude fat and nitrogen-free extract contents were not significantly different (p> 0.05) between the two leaf powders. The phytochemical screening revealed the presence of tannin, flavonoid, phenol, alkaloids, saponin and phytate. Except for alkaloid content, M. charantia leaf powder had higher tannins (1.20±0.02 mg/g), flavonoids (225.64±14.61 mg/g), phenol (21.04±0.57 mg/g), saponins (57.36±0.08 mg/g) and phytate (7.79±0.25 mg/g) content compared to O. gratissimum leaf powder. The antioxidant activity of the plants showed that M. charantia leaf powder possessed higher DPPH scavenging free radical activity than that of O. gratissimum leaf powder. The mineral constituents revealed that both plants contain a significant amount of zinc, calcium, iron and phosphorus, with M. charantia leaf powder having higher zinc and calcium concentration than O. gratissimum leaf powder (p < 0.05). In conclusion, this study shows that the leaf of M. charantia and O. gratissimum plants are rich sources of nutrients and phytochemicals and can be used as natural feed additives in animal nutrition.
Effectiveness of fitness for work interventions for workers with low back pain: A systematic review
Authors: Ishimaru Tomohiro , Chimed-Ochir Odgerel , Arphorn Sara , Fujino Yoshihisa
Published: August 2021

Objectives

Safety at work is important for workers with low back pain (LBP). This requires good job design that considers both worker capacities and work requirements, a concept called “Fitness for Work.” This systematic review aimed to evaluate the effects of fitness for work interventions on workers with LBP.

Methods

We searched PubMed, the Cochrane Library, and Scopus from 2000 through 2020, using relevant terms.

Results

We reviewed nine randomized controlled trials (RCTs) out of 3052 unique references. All studies were RCTs conducted in Western countries. Some RCTs reported positive findings that fitness for work interventions were effective for LBP in facilitating shorter return to work time and reducing short-term sick leave. However, the results of the reviewed studies were inconsistent; therefore, there is insufficient evidence to draw firm conclusions about the effectiveness of fitness for work interventions. Furthermore, the interventions were not effective in reducing long-term sick leave over a 24-month period. There were consistent findings that fitness for work interventions were no more effective than control interventions on pain intensity, disability, and work ability of workers with LBP.

Conclusions

These results suggest that fitness for work interventions may be somewhat effective in facilitating return to work and preventing short-term recurrence in workers with LBP. However, workers need to carefully manage their condition to prevent long-term recurrence.
Efficacy of ice slurry and carbohydrate–electrolyte solutions for firefighters
Authors: Tabuchi Shota , Horie Seichi , Kawanami Shoko , Inoue Daisuke , Morizane Shuhei , Inoue Jinro , Nagano Chikage , Sakurai Masao , Serizawa Ryo , Hamada Koichiro
Published: August 2021

Objectives

To examine the thermoregulatory and fluid-electrolyte responses of firefighters ingesting ice slurry and carbohydrate–electrolyte solutions before and after firefighting operations.

Methods

Twelve volunteer firefighters put on fireproof clothing and ingested 5 g/kg of beverage in an anteroom at 25°C and 50% relative humidity (RH; pre-ingestion), and then performed 30 minutes of exercise on a cycle ergometer (at 125 W for 10 minutes and then 75 W for 20 minutes) in a room at 35℃ and 50% RH. The participants then returned to the anteroom, removed their fireproof clothing, ingested 20 g/kg of beverage (post-ingestion), and rested for 90 minutes. Three combinations of pre-ingestion and post-ingestion beverages were provided: a 25℃ carbohydrate–electrolyte solution for both (CH condition); 25℃ water for both (W condition); and a −1.7℃ ice slurry pre-exercise and 25℃ carbohydrate–electrolyte solution post-exercise (ICE condition).

Results

The elevation of body temperature during exercise was lower in the ICE condition than in the other conditions. The sweat volume during exercise was lower in the ICE condition than in the other conditions. The serum sodium concentration and serum osmolality were lower in the W condition than in the CH condition.

Conclusions

The ingestion of ice slurry while firefighters were wearing fireproof clothing before exercise suppressed the elevation of body temperature during exercise. Moreover, the ingestion of carbohydrate–electrolyte solution by firefighters after exercise was useful for recovery from dehydration.
Effect of computed tomography value error on dose calculation in adaptive radiotherapy with Elekta X‐ray volume imaging cone beam computed tomography
Authors: Taniguchi Takuya , Hara Takanori , Shimozato Tomohiro , Hyodo Fuminori , Ono Kose , Nakaya Shuto , Noda Yoshifumi , Kato Hiroki , Tanaka Osamu , Matsuo Masayuki
Published: August 2021

Purpose

We evaluated the effect of changing the scan mode of the Elekta X‐ray volume imaging cone beam computed tomography (CBCT) on the accuracy of dose calculation, which may be affected by computed tomography (CT) value errors in three dimensions.

Methods

We used the electron density phantom and measured the CT values in three dimensions. CT values were compared with planning computed tomography (pCT) values for various materials. The evaluated scan modes were for head and neck (S‐scan), chest (M‐scan), and pelvis (L‐scan) with various collimators and filter systems. To evaluate the effects of the CT value error of the CBCT on dose error, Monte Carlo calculations of dosimetry were performed using pCT and CBCT images.

Results

The L‐scan had a CT value error of approximately 800 HU at the isocenter compared with the pCT. Furthermore, inhomogeneity in the longitudinal CT value profile was observed in the bone material. The dose error for ±100 HU difference in CT values for the S‐scan and M‐scan was within ±2%. The center of the L‐scan had a CT error of approximately 800 HU and a dose error of approximately 6%. The dose error of the L‐scan occurred in the beam path in the case of both single field and two parallel opposed fields, and the maximum error occurred at the center of the phantom in the case of both the 4‐field box and single‐arc techniques.

Conclusions

We demonstrated the three‐dimensional CT value characteristics of the CBCT by evaluating the CT value error obtained under various imaging conditions. It was found that the L‐scan is considerably affected by not having a unique bowtie filter, and the S‐scan without the bowtie filter causes CT value errors in the longitudinal direction. Moreover, the CBCT dose errors for the 4‐field box and single‐arc irradiation techniques converge to the isocenter.
From “East vs West” towards international multidisciplinary collaboration: An appraisal of lateral lymph nodes in rectal cancer
Authors: Sluckin Tania C. , Hazen Sanne‐Marije J. A. , Kusters Miranda
Published: August 2021

Western and Eastern practices have traditionally differed in their approach to treating lateral lymph nodes in rectal cancer. While Western clinicians have primarily favored neoadjuvant (chemo)radiotherapy to sterilize lateral compartments, Eastern physicians have often opted for the surgical removed of lymphatic tissue with a lateral lymph node dissection without neoadjuvant treatment. The literature suggests similar oncological outcomes for these two separate techniques, while tangible differences exist. The combination of these paradigms may be beneficial in reducing overall morbidity while sustaining low recurrence rates. This article considers traditional Eastern and Western perspectives, discusses nodal features important for predicting malignancy and attempts to stimulate international, multidisciplinary consensus and collaboration.
The intriguing methoxycarbonylation of trimethylsilylacetylene in the presence of Drent's catalytic system
Authors: Sole Roberto , Scrivanti Alberto , Alam Md. Mahbubul , Beghetto Valentina
Published: August 2021

The alkoxycarbonylation of trimethylsilylacetylene has been studied in order to develop an atom economic sustainable synthesis of 2‐(trimethylsilyl)acrylates, a family of valuable intermediates. Pd(OAc)2 in combination with CH3SO3H and diphenyl‐(pyridin‐2‐yl)phosphine or diphenyl‐(6‐methyl‐pyridin‐2‐yl)phosphine is an active catalyst for the reaction affording mixtures of the sought 2‐(trimethylsilyl)acrylate and the isomeric 3‐(trimethylsilyl)acrylate. The phosphine ligand has a dramatic effect on the reaction. When employing diphenyl‐(pyridin‐2‐yl)phosphine, it is necessary to carry out the reaction at 80°C in order to observe a modest catalytic activity, and the product is an almost equimolecular mixture of the two isomeric esters. On the contrary, when employing diphenyl‐(6‐methyl‐pyridin‐2‐yl)phosphine, the reaction proceeds under much milder conditions affording with high rate (turnover frequency [TOF] up to 1200 h−1) and selectivity (>95%) of the sought 2‐(trimethylsilyl)acrylate. The reaction conditions have been optimized, and the effects of phosphine/palladium, acid/palladium, reaction time, temperature, and CO pressure have been investigated.
The cerebellum is linked to theory of mind alterations in autism. A direct clinical and MRI comparison between individuals with autism and cerebellar neurodegenerative pathologies
Authors: Clausi Silvia , Olivito Giusy , Siciliano Libera , Lupo Michela , Laghi Fiorenzo , Baiocco Roberto , Leggio Maria
Published: August 2021

In recent years, structural and functional alterations in the cerebellum have been reported in autism spectrum disorder (ASD). Intriguingly, recent studies demonstrated that the social behavioral profile of individuals with cerebellar pathologies is characterized by a theory of mind (ToM) impairment, one of the main behavioral hallmarks of ASD. The aim of the present study was to compare ToM abilities and underlying cerebello‐cortical structural patterns between ASD individuals and individuals with cerebellar atrophy to further specify the cerebellar role in mentalizing alterations in ASD. Twenty‐one adults with ASD without language and intellectual impairments (based on DSM‐5), 36 individuals affected by degenerative cerebellar damage (CB), and 67 healthy participants were enrolled in the study. ToM abilities were assessed using the reading the mind in the eyes test and the faux pas test. One‐way ANCOVA was conducted to compare the performances between the two cohorts. Three‐dimensional T1‐weighted magnetic resonance scans were collected, and a voxel‐based morphometry analysis was performed to characterize the brain structural alterations in the two cohorts. ASD and CB participants had comparable ToM performance with similar difficulties in both the tests. CB and ASD participants showed an overlapping pattern of gray matter (GM) reduction in a specific cerebellar portion (Crus‐II). Our study provides the first direct comparison of ToM abilities between ASD and CB individuals, boosting the idea that specific cerebellar structural alterations impact the mentalizing process. The present findings open a new perspective for considering the cerebellum as a potential target for treatment implementation. The present work will critically advance current knowledge about the cerebellar role in ToM alterations of ASD, in particular, elucidating the presence of common cerebellar structural abnormalities in ASD and cerebellar individuals that may underlie specific mentalizing alterations. These findings may pave the way for alternative therapeutic indications, such as cerebellar neuromodulation, with a strong clinical impact.

Lay Summary

The present work will critically advance current knowledge about the cerebellar role in theory of mind alterations of autism spectrum disorder (ASD), in particular, elucidating the presence of common cerebellar structural abnormalities in ASD and cerebellar individuals that may underlie specific mentalizing alterations. These findings may pave the way for alternative therapeutic indications, such as cerebellar neuromodulation, with a strong clinical impact.
Dual‐Ion NiNc Battery: A Sustainable Revolution for Sodium Organic Batteries
Authors: Hwang Jinkwang , Matsumoto Kazuhiko , Hagiwara Rika , Ukai Shusaku , Shinokubo Hiroshi , Shin Ji‐Young
Published: August 2021

Dual‐ion mobilities of Na organic batteries are investigated with in‐situ XRD analysis and computational estimation considering molecular alignments in the solid state, signifying the interactive variations of ionic‐pairs of an ionic liquid electrolyte and an antiaromatic molecule, nickel(II) norcorrole (NiNc). An appropriate cavity sphere in three‐dimensional molecular alignments dispensed mobilities of dual‐ion in an ionic liquid, resulting in high battery capacities, supplemented with the comparison of Mes‐NiNc and Ph‐NiNc molecular alignments. In‐situ XRD experiment, computation, and simulation perspectives afforded prospective insertion and desertion behaviors of cations and anions.
Engineering human skin model innervated with itch sensory neuron‐like cells differentiated from induced pluripotent stem cells
Authors: Guo Zongyou , Tong Chi‐Kun , Jacków Joanna , Doucet Yanne S. , Abaci Hasan E. , Zeng Wangyong , Hansen Corey , Hayashi Ryota , DeLorenzo Dominick , Rami Avina , Pappalardo Alberto , Lumpkin Ellen A. , Christiano Angela M.
Published: August 2021

Atopic dermatitis (AD), driven by interleukins (IL‐4/IL‐13), is a chronic inflammatory skin disease characterized by intensive pruritus. However, it is unclear how immune signaling and sensory response pathways cross talk with each other. We differentiated itch sensory neuron‐like cells (ISNLCs) from iPSC lines. These ISNLCs displayed neural markers and action potentials and responded specifically to itch‐specific stimuli. These ISNLCs expressed receptors specific for IL‐4/IL‐13 and were activated directly by the two cytokines. We successfully innervated these ISNLCs into full thickness human skin constructs. These innervated skin grafts can be used in clinical applications such as wound healing. Moreover, the availability of such innervated skin models will be valuable to develop drugs to treat skin diseases such as AD.
Review disclosure conditions for health and safety emergencies
Authors: Rainsberger Richard
Published: August 2021

A vice president of student services asked me last month about a student who had violated the university's  COVID‐19 testing program. The student's records were sent to a hearing panel. The student was subsequently dismissed until this fall.
Use ADA settlement agreements as guide for monitoring compliance
Authors: Charmatz Marc
Published: August 2021

The U.S. Department of Justice recently settled two complaints against colleges under Title II of the Americans with Disabilities Act — United States of America and Tidewater Community College, DJ #204‐79‐334 (see www.ada.gov/tidewater_cc_sa.html) and United States of America and Central Texas College of Killeen (see www.ada.gov/ctc_sa.html).
Free speech case offers new perspective for controversial social media posts
Authors: O'Brien Timothy
Published: August 2021

A recent decision by the U.S. Supreme Court involving a student‐athlete's comments on a social media platform provides an interesting update on First Amendment protections for off‐campus speech about school teams.
Did court dismiss due process lawsuit filed by Ph.D. student?
Authors: Lyerly Eric
Published: August 2021

A Ph.D. student in the University of Utah's Department of Economics was a native of Chad. The student   received both his bachelor's and master's degrees from the university.
Labelling of human Wharton's jelly‐derived mesenchymal stem cells with gold nanorods by biomimicry method
Authors: Qiyami Hour Farshid , Shabani Ronak , Ashtari Behnaz , Moinzadeh Alaa , Mehdizadeh Mehdi
Published: August 2021

Mesenchymal stem cell (MSC)‐based cell therapy can provide opportunities for the treatment of various diseases. However, when used in vivo, these cells should be labelled and monitored by a non‐invasive method during delivery to the desired locations within the body. This study describes a biomimicry method that effectively labels human Wharton's jelly‐derived MSCs (hWJ‐MSCs) with a photoacoustics (PA) contrast agent, gold nanorods (GNRs), without the need for transfection agents (TAs). In this method for cell labelling, the hWJ‐MSCs were co‐incubated with non‐adherent cells isolated from fresh umbilical cord for 2 days immediately before incubation with GNRs. Next, hWJ‐MSCs were labelled with the GNRs at a concentration of approximately 1010 nanorads/mL (NR/mL) followed by transmission electron microscopy (TEM) and inductively coupled plasma mass spectroscopy (ICP‐MS) to verify their labelling effectiveness. The GNRs‐labelled MSCs prepared by this method had an intracellular gold (Au) concentration of 3.4 ± 0.4 pg/cell, which is an acceptable amount for cell labelling.
Potent Tau Aggregation Inhibitor D‐Peptides Selected against Tau‐Repeat 2 Using Mirror Image Phage Display
Authors: Malhis Marwa , Kaniyappan Senthilvelrajan , Aillaud Isabelle , Chandupatla Ram Reddy , Ramirez Lisa Marie , Zweckstetter Markus , Horn Anselm H. C. , Mandelkow Eckhard , Sticht Heinrich , Funke Susanne Aileen
Published: August 2021

Alzheimer's disease and other Tauopathies are associated with neurofibrillary tangles composed of Tau protein, as well as toxic Tau oligomers. Therefore, inhibitors of pathological Tau aggregation are potentially useful candidates for future therapies targeting Tauopathies. Two hexapeptides within Tau, designated PHF6* (275‐VQIINK‐280) and PHF6 (306‐VQIVYK‐311), are known to promote Tau aggregation. Recently, the PHF6* segment has been described as the more potent driver of Tau aggregation. We therefore employed mirror‐image phage display with a large peptide library to identify PHF6* fibril binding peptides consisting of D‐enantiomeric amino acids. The suitability of D‐enantiomeric peptides for in vivo applications, which are protease stable and less immunogenic than L‐peptides, has already been demonstrated. The identified D‐enantiomeric peptide MMD3 and its retro‐inverso form, designated MMD3rev, inhibited in vitro fibrillization of the PHF6* peptide, the repeat domain of Tau as well as full‐length Tau. Dynamic light scattering, pelleting assays and atomic force microscopy demonstrated that MMD3 prevents the formation of tau β‐sheet‐rich fibrils by diverting Tau into large amorphous aggregates. NMR data suggest that the D‐enantiomeric peptides bound to Tau monomers with rather low affinity, but ELISA (enzyme‐linked immunosorbent assay) data demonstrated binding to PHF6* and full length Tau fibrils. In addition, molecular insight into the binding mode of MMD3 to PHF6* fibrils were gained by in silico modelling. The identified PHF6*‐targeting peptides were able to penetrate cells. The study establishes PHF6* fibril binding peptides consisting of D‐enantiomeric amino acids as potential molecules for therapeutic and diagnostic applications in AD research.
Pop the balloon: rapid switch from Intra‐aortic balloon pump to alternate device
Authors: Long Ashleigh , Stelling Kelly , Baran David A.
Published: August 2021

When a patient with an intra‐aortic balloon pump needs different support, it is simple to use a stiff 0.018‐inch interventional wire (360 cm) to exchange the balloon for a new sheath. This allows the team to start with a balloon and then switch if the support is not sufficient.
Spontaneous resolution of nonimmune hydrops fetalis in a fetus with TP63 gene mutation and LZTR1 gene variants
Authors: Hurni Yannick , Marangoni Martina , Garofalo Giulia , Cassart Marie , Tomasi Lisa , Vandernoot Isabelle , Smits Guillaume , Gounongbé Caroline
Published: August 2021

In cases of fetal hydrops, searching for an etiology is essential to evaluate the fetal prognosis and propose the most appropriate management.
Fluorine Doping Induced Crystal Space Change and Performance Improvement of Single Crystalline LiNi0.6Co0.2Mn0.2O2 Layered Cathode Materials
Authors: Huang Xiao , Zhang Pengfei , Liu Zhaofeng , Ma Ben , Zhou Yingke , Tian Xiaohui
Published: August 2021

The Li−Ni−Co−Mn−O layered cathode materials are promising for the advanced lithium‐ion batteries due to their moderate cost and high specific capacity. However, the low electronic conductivity and poor stability at high currents need to be overcome to meet the ever‐growing demands. In this work, single crystal hexagonal nanosheets of LiNi0.6Co0.2Mn0.2O2 are synthesized by the hydrothermal process, which are further controllably doped with fluorine to improve the lithium storage performance. The fluorine doping can not only improve the layered structure, but also increase the lattice oxygen content, to promote the lithium‐ion migration and crystal structure stability of the layered LiNi0.6Co0.2Mn0.2O2. Optimized fluorine doping leads to excellent capacity and cyclic stability of the single crystal LiNi0.6Co0.2Mn0.2O2 nanosheets with an original capacity of 168.3 mAh g−1, and an excellent capacity retention rate of 94.5 % at 1.0 C over 100 cycles, which are superior to the control samples and hold potential for the lithium‐ion battery applications.
Disclosure of Ground‐State Zimmerman‐Möbius Aromaticity in the Radical Anion of [6]Helicene and Evidence for 4π Periodic Aromatic Ring Currents in a Molecular “Metallic” Möbius Strip
Authors: Mauksch Michael , Tsogoeva Svetlana B.
Published: August 2021

In 1966, Zimmerman proposed a type of Möbius aromaticity that involves through‐space electron delocalization; it has since been widely applied to explain reactivity in pericyclic reactions, but is considered to be limited to transition‐state structures. Although the easily accessible hexahelicene radical anion has been known for more than half a century, it was overlooked that it exhibits a ground‐state minimum and robust Zimmerman‐Möbius aromaticity in its central noose‐like opening, becoming, hence, the oldest existing Möbius aromatic system and with smallest Möbius cycle known. Despite its overall aromatic stabilization energy of 13.6 kcal mol−1 (at B3LYP/6‐311+G**), the radical also features a strong, globally induced paramagnetic ring current along its outer edge. Exclusive global paramagnetic currents can also be found in other fully delocalized radical anions of 4N+2 π‐electron aromatic polycyclic benzenoid hydrocarbons (PAH), thus questioning the established magnetic criterion of antiaromaticity. As an example of a PAH with nontrivial topology, we studied a novel Möbius[16]cyclacene that has a non‐orientable surface manifold and a stable closed‐shell singlet ground state at several density functional theory levels. Its metallic monoanion radical (0.0095 eV band gap at HSE06/6‐31G* level) is also wave‐function stable and displays an unusual 4π‐periodic, magnetically induced ring current (reminiscent of the transformation behaviour of spinors under spatial rotation), thus indicating the existence of a new, Hückel‐rule‐evading type of aromaticity.
Alkene Synthesis by Photo‐Wolff‐Kischner Reaction of Sulfur Ylides andN‐Tosylhydrazones
Authors: Gao Pan‐Pan , Yan Dong‐Mei , Bi Ming‐Hang , Jiang Min , Xiao Wen‐Jing , Chen Jia‐Rong
Published: August 2021

A visible‐light‐driven and room temperature photo‐Wolff‐Kischner reaction of sulfur ylides and N‐tosylhydrazones has been developed for the first time to provide modular access to alkene synthesis. The high functional group tolerance and broad substrate scope were demonstrated by more than 60 examples. Both E‐ and Z‐olefinic stereochemistry in the products could be controlled with excellent stereoselectivity. A series of mechanistic studies support that the reaction should proceed through a radical‐carbanion crossover pathway, specifically involving addition of photo‐generated sulfur ylide radical cations to N‐tosylhydrazones to form carbanions and subsequent Wolff‐Kischner process.
Defect Luminescence Based Persistent Phosphors—From Controlled Synthesis to Bioapplications
Authors: Ji Cailing , Tan Jie , Yuan Quan
Published: August 2021

Persistent luminescence is an optical phenomenon where solid phosphors can store photoenergy in defects and release the energy by luminescence after stopping excitation. Due to the intriguing optical characteristics, the defect luminescence based persistent phosphors have attracted enormous attention in recent decades, especially in biomedical fields such as biosensing and bioimaging. Persistent luminescence nanoparticles (PLNPs) can effectively avoid the autofluorescence interference from complex samples or tissues, leading to significantly improved sensitivity in biological analysis. In this review, we summarized the methods to control the optical performance of PLNPs from the perspectives of controlled synthesis and defect regulation, and emphasized the close relationship between their optical performance and applications. We further provided a summary about a series of PLNPs nanoprobes designed by our group for biosensing and bioimaging. Our efforts, summarized in this review, will not only open a window for manipulating luminescence in PLNPs, but also further promote the application of PLNPs in biomedicine.

What is the most favorite and original chemistry developed in your research group?

Synthesis and bioapplications of persistent phosphors.

How do you get into this specific field? Could you please share some experiences with our readers?

I got into chemistry related to biomedicine during my graduate student period. The research situation of luminescent nanomaterials in China has a strong effect on me, inspiring me to pursuit new luminescent nanomaterials and their applications.

We need have interest and concentrate on our research with passion. We are encouraged to work hard.

What is the most important personality for scientific research?

Curiosity and hard‐working.

What are your hobbies? What's your favorite book(s)?

Shopping and reading books. My favorite books are novels, such as “The Three‐Body Problem”.

How do you keep balance between research and family?

I have two boys and it takes me much time to take care of them. I need to elevate my work efficiency and work hard. I also buy household service to save time.

Who influences you mostly in your life?

My father. He loves reading and writing. I know one need to have passion on something under my father's influence.
c‐MYC and p53 expression highlight starry‐sky pattern as a favourable prognostic feature in R‐CHOP‐treated diffuse large B‐cell lymphoma
Authors: Bouroumeau Antonin , Bussot Lucile , Bonnefoix Thierry , Fournier Cyril , Chapusot Caroline , Casasnovas Olivier , Martin Laurent , McLeer Anne , Col Edwige , David‐Boudet Laurence , Lefebvre Christine , Algrin Caroline , Raskovalova Tatiana , Jacob Marie‐Christine , Vettier Claire , Chevalier Simon , Callanan Mary B , Gressin Rémy , Emadali Anouk , Sartelet Hervé
Published: August 2021

Diffuse large B‐cell lymphoma (DLBCL) is a clinically heterogeneous entity, in which the first‐line treatment currently consists of an immuno‐chemotherapy regimen (R‐CHOP). However, around 30% of patients will not respond or will relapse. Overexpression of c‐MYC or p53 is frequently found in DLBCL, but an association with prognosis remains controversial, as for other biomarkers previously linked with DLBCL aggressivity (CD5, CD23, or BCL2). The aim of this study was to explore the expression of these biomarkers and their correlation with outcome, clinical, or pathological features in a DLBCL cohort. Immunohistochemical (c‐MYC, p53, BCL2, CD5, and CD23), morphological (‘starry‐sky’ pattern [SSP]), targeted gene panel sequencing by next‐generation sequencing (NGS), and fluorescence in situ hybridisation analyses were performed on tissue microarray blocks for a retrospective cohort of 94 R‐CHOP‐treated de novo DLBCL. In univariate analyses, p53 overexpression (p53high) was associated with unfavourable outcome (p = 0.04) and with c‐MYC overexpression (p = 0.01), whereas c‐MYC overexpression was linked with an SSP (p = 0.004), but only tended towards an inferior prognosis (p = 0.06). Presence of a starry‐sky morphology was found to be correlated with better survival in p53high DLBCL (p = 0.03) and/or c‐MYC‐positive DLBCL (p = 0.002). Furthermore, NGS data revealed that these three variables were associated with somatic mutations (PIM1, TNFRSF14, FOXO1, and B2M) involved in B‐cell proliferation, survival, metabolism, and immune signalling. Taken together, these results show that the SSP pattern seems to be a protective factor in high‐risk DLBCL subgroups and highlight cell death as a built‐in failsafe mechanism to control tumour growth.
Blood and Marrow Transplant Clinical Trials Network Study 1102 heralds a new era in hematopoietic cell transplantation in high‐risk myelodysplastic syndromes: Challenges and opportunities in implementation
Authors: Warlick Erica D. , Ustun Celalettin , Andreescu Astrid , Bonagura Anthony F. , Brunner Andrew , Chandra Abhinav B. , Foran James M. , Juckett Mark B. , Kindwall‐Keller Tamila L. , Klimek Virginia M. , Pease Daniel F. , Steensma David P. , Waldman Bryce M. , Horowitz Mary M. , Burns Linda J. , Khera Nandita
Published: August 2021

Lay Summary

People who have advanced myelodysplastic syndromes (MDS) may live longer if they get a bone marrow transplant (BMT) instead of other therapies. However, only 15% of people with MDS actually get BMT.

Experts say community physicians and transplant physicians should team up with insurance companies and patient advocacy groups to 1) spread this news about lifesaving advances in BMT, 2) ensure that everyone can afford health care, 3) provide emotional support for patients and families, 4) help patients and families get transportation and housing if they need to travel for transplant, and 5) improve care for people of under‐represented racial and ethnic backgrounds.