bluuebunny/crossref_metadata_2025 huggingface dataset:
Lipid Profile and Small Dense Low-Density Lipoprotein in Acute Coronary Syndrome Patients: Relationships to Demographic, Clinical, Angiographic, and Therapeutic Variables
Authors: Pradhan Akshyaya , Kuka Ravninder , Vishwakarma Pravesh , Ali Wahid , Perrone Marco Alfonso , Iellamo Ferdinando , Chaudhary Gaurav , Chandra Sharad , Sethi Rishi , Dwivedi Sudhanshu , Narain Varun , Saran R. K.
Published: November 2022

Background: Several lines of evidence have supported small dense low-density lipoproteins (sd-LDL) as a marker of cardiovascular disease. The present study assessed the relationship between lipid profile and sd-LDL levels with demographic, clinical, angiographic, and therapeutic variables in acute coronary syndrome (ACS) patients. Methods: This was a single-centre, prospective, cross-sectional study conducted from September 2014 to September 2015. Patients with a diagnosis of ACS were included in this study. High-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were determined by direct homogenous assay and sd-LDL levels were calculated using an earlier described equation by Srisawadi et al. Results: A total of 200 patients with a diagnosis of ACS were studied. Males constituted 78% of the population cohort and almost 45% of participants were aged <45 years. Patients aged ≤45 years displayed higher mean sd-LDL levels of 30.40 ± 14.18 mg/dL versus patients aged >45 years with mean sd-LDL levels of 28.01 ± 11.58 mg/dL, but the difference was not statistically significant (p = 0.19). Females also displayed higher mean sd-LDL levels, but the difference also failed to achieve statistical significance (30.95 ± 13.44 mg/dL and 28.54 ± 12.64, respectively; p = 0.185). Diabetics had higher mean sd-LDL levels (33.64 ± 13.01 mg/dL and 28.07 ± 12.60 mg/dL; p = 0.273) whilst smokers had lower mean levels (27.21 ± 12.12 mg/dL and 30.51 ± 13.21 mg/dL, respectively; p = 0.071). However, the ratio of sd-LDL/lb-LDL (large buoyant LDL) was significantly higher in diabetics (0.48 vs. 0.39; p = 0.023). In the angiography cohort (n = 88), single-vessel disease was the most predominant overall while among patients aged >45 years, triple-vessel disease was significantly higher (p = 0.005). Similarly, the sd-LDL levels were 33.12 ± 11.13 mg/dL, 27.68 ± 9.80 mg/dL, and 31.65 ± 15.26 mg/dL among patients with single, double, and triple-vessel disease and did not differ significantly (p = 0.262). Prior statin users had significantly lower mean sd-LDL levels of 24.79 ± 12.23 mg/dL compared to statin-naïve patients with a mean sd-LDL of 30.01 ± 12.79 mg/dL (p = 0.027). Non-HDL levels were also significantly lower in prior statin users (112.83 mg/dL vs. 128.9 mg/dL; p = 0.017). Conclusion: In this cohort of ACS patients, age, sex, diabetes, smoking, and the angiographic severity of coronary artery disease had no significant impact on sd-LDL levels, while prior statin usage led to significantly lower sd-LDL levels. Diabetic patients, however, did have significantly higher sd-LDL/lb-LDL ratios.
Reoperation for Recurrent and Persistent Cushing’s Disease without Visible MRI Findings
Authors: Wang Baofeng , Zheng Shuying , Ren Jie , Zhong Zhihong , Jiang Hong , Sun Qingfang , Su Tingwei , Wang Weiqing , Sun Yuhao , Bian Liuguan
Published: November 2022

Purpose: Transsphenoidal surgery is the first-line treatment for Cushing’s disease (CD), even with negative preoperative magnetic resonance imaging (MRI) results. Some patients with persistent or recurring hypercortisolism have negative MRI findings after the initial surgery. We aimed to analyze the efficacy of repeat surgery in two groups of patients and determine if there is an association between positive MRI findings and early remission. Patients and Methods: Clinical, imaging, and biochemical information of 42 patients who underwent repeat surgery by a single neurosurgeon between 2002 and 2021 was retrospectively analyzed. We compared the endocrinological, histopathological, and surgical outcomes before and after repeat surgery among 14 CD patients with negative MRI findings and 28 patients with positive MRI findings. Results: Immediate remission was achieved in 29 patients (69.0%) who underwent repeat surgery. Among all patients, 28 (66.7%) had MRI findings consistent with solid lesions. There was no significant difference in remission rates between the recurrence and persistence groups (77.8% vs. 57.1%, odds ratio = 2.625, 95% confidence interval = 0.651 to 10.586). Patients in remission after repeat surgery were not associated with positive MRI findings (odds ratio = 3.667, 95% confidence interval = 0.920 to 14.622). Conclusions: In terms of recurrence, repeat surgery in patients with either positive or negative MRI findings showed reasonable remission rates. For persistent disease with positive MRI findings, repeat surgery is still an option; however, more solid evidence is needed to determine if negative MRI findings are predictors for failed reoperations for persistent hypercortisolism.
Changes in Serum Creatinine May Cause Hypoglycemia among Non-Critically Ill Patients Admitted to Internal Medicine Units
Authors: Zingerman Boris , Khanimov Israel , Shimonov Mordechai , Boaz Mona , Rozen-Zvi Benaya , Leibovitz Eyal
Published: November 2022

Background: The association between changes in serum creatinine levels and hypoglycemia during hospitalization was investigated. Methods: This was a retrospective analysis of medical charts. Patients were categorized as having significant change in creatinine (SCIC) when serum creatinine levels rose or dropped ≥ 0.3 mg/dL from admission values at any time during their hospitalization. Patients were considered hypoglycemic if they had at least one documented glucose level ≤ 70 mg/dL during the hospitalization. Multiple logistic, linear and Cox regression analyses were used to ascertain the association between incident SCIC, severity and timing with incident hypoglycemia. Results: Included were 25,400 (mean age 69.9 ± 18.0, 49.3% were males). The rate of SCIC was 22.2%, and 62.2% of them were diagnosed upon admission. Patients with SCIC had a higher incidence of hypoglycemia compared to patients without (13.1% vs. 4.1%, respectively, p < 0.001). Patients with SCIC had an increased risk of hypoglycemia (OR 1.853, 95% CI 1.586–2.166, p < 0.001). The magnitude of SCIC was associated with the incidence (OR 1.316, 95% CI 1.197–1.447, p < 0.001) and the number of events (HR 0.054, 95% CI 0.021–0.087, p = 0.001). More than 60% of patients with hypoglycemia had their first event documented during days 0–6 after SCIC occurrence. Of those, the majority of events occurred on day 0–1, and the rate showed a gradual decrease throughout the first 5 days from SCIC occurrence. The results were similar for patients with and without DM. Conclusions: Changes in creatinine during hospitalization may cause hypoglycemia among patients admitted to internal medicine departments, regardless of DM status.
Comparing a Fully Automated Cephalometric Tracing Method to a Manual Tracing Method for Orthodontic Diagnosis
Authors: Tsolakis Ioannis A. , Tsolakis Apostolos I. , Elshebiny Tarek , Matthaios Stefanos , Palomo J. Martin
Published: November 2022

Background: This study aims to compare an automated cephalometric analysis based on the latest deep learning method of automatically identifying cephalometric landmarks with a manual tracing method using broadly accepted cephalometric software. Methods: A total of 100 cephalometric X-rays taken using a CS8100SC cephalostat were collected from a private practice. The X-rays were taken in maximum image size (18 × 24 cm lateral image). All cephalometric X-rays were first manually traced using the Dolphin 3D Imaging program version 11.0 and then automatically, using the Artificial Intelligence CS imaging V8 software. The American Board of Orthodontics analysis and the European Board of Orthodontics analysis were used for the cephalometric measurements. This resulted in the identification of 16 cephalometric landmarks, used for 16 angular and 2 linear measurements. Results: All measurements showed great reproducibility with high intra-class reliability (>0.97). The two methods showed great agreement, with an ICC range of 0.70–0.92. Mean values of SNA, SNB, ANB, SN-MP, U1-SN, L1-NB, SNPg, ANPg, SN/ANS-PNS, SN/GoGn, U1/ANS-PNS, L1-APg, U1-NA, and L1-GoGn landmarks had no significant differences between the two methods (p > 0.0027), while the mean values of FMA, L1-MP, ANS-PNS/GoGn, and U1-L1 were statistically significantly different (p < 0.0027). Conclusions: The automatic cephalometric tracing method using CS imaging V8 software is reliable and accurate for all cephalometric measurements.
Triple Antiplatelet Therapy with Cilostazol and Favorable Early Clinical Outcomes after Acute Myocardial Infarction Compared to Dual Antiplatelet Therapy with Standard or Potent P2Y12 Inhibitors
Authors: Byun Sungwook , Lee Su , Lim Sungmin , Choo Eun , Choi Ik , Kim Chan , Moon Donggyu , Park Mahn-Won , Park Chul , Ahn Youngkeun , Jeong Myung-Ho , Chang Kiyuk
Published: November 2022

Current guidelines for the management of acute myocardial infarction (AMI) recommend potent P2Y12 inhibitors rather than clopidogrel to prevent ischemic events. However, their ischemic benefits are offset by an increased major bleeding risk. We compared the efficacy and safety of triple antiplatelet therapy with cilostazol in the first month after AMI. This study investigated 16,643 AMI patients who received percutaneous coronary intervention (PCI) with drug-eluting stents (DES) in nationwide, real-world, multicenter registries in Korea. Patients were divided into DAPT (aspirin and clopidogrel, n = 11,285), Triple (aspirin, clopidogrel and cilostazol, n = 2547), and Potent (aspirin and ticagrelor/prasugrel, n = 2811) groups. The primary outcomes were net adverse clinical events (NACE), a composite of death from any cause, myocardial infarction (MI), stroke, and TIMI major bleeding one month after AMI. After adjusting for covariates, there were no statistically significant differences in the risk of death from any cause, MI, or stroke between the three groups. However, the risk of TIMI major bleeding was significantly greater in the Potent group than in the DAPT and Triple groups (p < 0.001). Accordingly, NACE was significantly higher in the DAPT (HR 1.265; 95% CI 1.006–1.591, p = 0.044) and Potent groups (HR 1.515; 95% CI 1.142–2.011, p = 0.004) than in the Triple group. Triple antiplatelet therapy with cilostazol was associated with an improved net clinical outcome in the first month after AMI without increasing the risk of bleeding compared to potent or standard P2Y12 inhibitor-based DAPT.
Long-Term Spatiotemporal Changes in Ecosystem Services Caused by Coastal Wetland Type Transformation in China’s Hangzhou Bay
Authors: Liang Haiji , Chen Chong , Wang Kexin , Ye Guanqiong
Published: November 2022

Coastal wetlands provide essential ecosystem services, while usually experiencing land transformation or degradation mainly due to intense anthropogenic activities and climate changes. Understanding the changes in wetlands ecosystem services is essential to decision makers for generating sound coastal planning. Hangzhou Bay is rich in wetland resources, and the urbanization of Hangzhou Bay in the past three decades has caused fundamental changes in the wetlands in the region. Based on the remote sensing images of the Hangzhou Bay area from 1990 to 2020, this paper analyzes the land use situation of the Hangzhou Bay area in seven periods. This paper calculates the area transfer matrix of various types of wetlands. It uses the InVEST model to evaluate the changes in the function of wetland ecosystem services in the Hangzhou Bay area. Hangzhou Bay wetlands show a trend of transferring natural wetlands to artificial and non-wetlands from 1990 to 2020. Carbon stocks fell by 14.24%. The annual water production decreased by 33.93% and then returned to the original level. The area of habitat degradation increased by 79.94%. The main influencing factors are paddy field degradation, increase in non-wetland area, and decrease in sea area. This paper proposes that the development and construction of farmland in the “red line” area and established wetland reserves are prohibited, and to strengthen the training of wetland management personnel, establish a sound decision-making consultation mechanism, and increase the scientific research expenditure on wetlands in the region.
Design, Simulation, and Experimental Study on the Hydraulic Drive System of an AUV Docking Device with Multi-Degree Freedom
Authors: Du Xiaofei , Zong Chaoyong , Zhang Bo , Shi Maolin
Published: November 2022

AUV docking devices have the ability to achieve homing of the AUV, supply the AUV with energy, and exchange data with it, thus improving the endurance and ensuring the continuous long-term and large-scale operation of the AUV. To improve the successful docking rate of the AUV, a funnel-shaped underwater docking device with multi-degree freedom based on a deep-sea platform was designed in this paper. The heading angle, pitch angle, and roller angle of the docking device could be adjusted in a timely manner according to the current flow direction and the position of the AUV. In order to realize the timely adjustment of the heading angle, pitch angle, and roll angle of the docking device, a set of underwater hydraulic systems was developed as the power source to drive the corresponding hydraulic cylinders, hydraulic motors, and other executive components. The model of the heading angle adjustment circuit of the hydraulic system was established and the open-loop transfer function of the heading angle adjustment circuit was derived. The dynamic response performance of the hydraulic circuit was simulated and the optimized PID algorithm was used to improve the dynamic response performance. Finally, the accuracy of the heading angle adjustment circuit model and the effectiveness of the control algorithm were validated by experiment of the docking device in a water pool.
Pb Transfer Preference of Arbuscular Mycorrhizal Fungus Rhizophagus irregularis in Morus alba under Different Light Intensities
Authors: Ren Wei , Zhang Haoqiang , Jin Xiaoxia , Huang Hongchao , Zhou Linxi , Xu Tingying , Tang Ming
Published: November 2022

Arbuscular mycorrhizal (AM) fungi can improve the lead (Pb) tolerance of host plants and accumulate intensive Pb in mycorrhizal roots. However, the detailed contribution of AM fungal extraradical hyphae to the plants’ Pb uptake remains unknown. In this study, mulberry (Morus alba) colonized by the AM fungus (Rhizophagus irregularis) with light treatments were linked by fungal extraradical hyphae using a three-compartment system (pot test), and their differences in responding to Pb application were compared. Shading inhibited mulberry photosynthesis and the growth of mulberry. In this study, Pb application did not affect the colonization of R. irregularis when symbiosis had already formed as the root was not exposed to Pb during the colonization and formation of the AM fungal hyphae network. The R. irregularis preferred to transfer more Pb to the unshaded mulberry than to the shaded mulberry, a condition capable of providing more C supply for fungal survival than to low-light mulberry. The Pb transferred through the mycorrhizal pathway to mulberry had low mobility and might be compartmented in the root by R. irregularis until exceeding a threshold. The relatively high expressions of MaABCG16 with high Pb concentrations in plants suggest that MaABCG16 might play an important role in Pb translocation.
Relationships between ESG Disclosure and Economic Growth: A Critical Review
Authors: Hassani Bertrand Kian , Bahini Yacoub
Published: November 2022

The literature on the relationship between ESG disclosure and economic growth is relatively non-existent. Thus, this paper highlights the importance of taking this relationship into account in current sustainable policies. The main objective of extra-financial Disclosure is to mitigate Information Asymmetry. During this discussion, we show that ESG disclosure may not reduce information asymmetry as intended. We also show that complete extra-financial disclosure targeted by current policies is not optimal. There is an optimal disclosure threshold depending on the level of sustainable development of the country, the size of the companies and their development potential. Moreover, current ESG disclosure policies direct economies towards less polluting sectors, which is not necessarily optimal from an economic standpoint and could negatively affect economic activity and, therefore, the population’s well-being. We also provide some policy implications and suggestions for future research on the ESG disclosure literature.
Effects of Supplier’s Competitive Factors on Relationship Performance and Product Recommendation in Crop Protection Retail Sector
Authors: Ahn Byungok , Kim Boyoung , Yu Jongpil
Published: November 2022

The changes in distribution channels of the crop protection industry are accelerating the influence of crop protection retailers on farmers’ product purchase decisions. This study aims to identify the critical competitive factors; ‘product quality’, ‘supply price’, ‘brand awareness’, ‘flexibility’, and ‘promotion support’; of crop protection manufacturers. And it empirically analyzes effects of the critical factors on relationship performance and product recommendation of crop protection retailers. This research also examined the difference among these major factors according to the level of trust of crop protection companies as suppliers. Survey data were collected from 660 retailers by the crop protection distribution market in South Korea. As for the results, the five factors were defined as the crop protection suppliers’ competitive factors. Supply price, promotion support, brand awareness, and flexibility had a positive (+) effect on relationship performance. Brand awareness, promotion support, product quality, and flexibility had a positive (+) effect on customer recommendation. Furthermore, supply price significantly affected relationship performance in a group with high trust, and promotion support significantly affected a group with low trust.
Tourism Industry Attitudes towards National Parks and Wilderness: A Case Study from the Icelandic Central Highlands
Authors: Sæþórsdóttir Anna Dóra , Wendt Margrét , Ólafsdóttir Rannveig
Published: November 2022

National parks serve a dual purpose: they aim to protect pristine nature and they are intended to facilitate visitation and provide necessary services. However, as visitation increases, it becomes challenging to establish a balance between visitation and the preservation of nature. This paper aims to examine the attitudes of tourism service providers in Iceland towards a proposed national park in the Central Highlands of Iceland, where pristine nature and wilderness are the main attraction, as well as the grounds for conservation. A mixed methodological approach was applied with an online questionnaire survey among all day-tour operators and travel agencies in Iceland, along with 48 semi-structured interviews as follow-up for a deeper understanding. In total, 382 companies answered the online survey, representing a 40% response rate. The results demonstrate that there are mixed opinions on whether the establishment of a national park is the best way to maintain the qualities of the area, with various arguments for and against the national park. Nevertheless, most tourism service providers want to have a say in its governance. It is however important to remember that the tourism industry exploits nature as a market-driven commodity, as its voice must always be evaluated in light of this.
Hyperspectral PRISMA and Sentinel-2 Preliminary Assessment Comparison in Alba Fucens and Sinuessa Archaeological Sites (Italy)
Authors: Alicandro Maria , Candigliota Elena , Dominici Donatella , Immordino Francesco , Masin Fabrizio , Pascucci Nicole , Quaresima Raimondo , Zollini Sara
Published: November 2022

Over the last decades, remote sensing techniques have contributed to supporting cultural heritage studies and management, including archaeological sites as well as their territorial context and geographical surroundings. This paper aims to investigate the capabilities and limitations of the new hyperspectral sensor PRISMA (Precursore IperSpettrale della Missione Applicativa) by the Italian Space Agency (ASI), still little applied to archaeological studies. The PRISMA sensor was tested on Italian terrestrial (Alba Fucens, Massa D’Albe, L’Aquila) and marine (Sinuessa, Mondragone, Caserta) archaeological sites. A comparison between PRISMA hyperspectral imagery and the well-known Sentinel-2 Multi-Spectral Instrument (MSI) was performed in order to better understand features and outputs useful to investigate the aforementioned areas. At first, bad bands analysis and noise removal were performed, in order to delete the numerically corrupted bands. Principal component analysis (PCA) was carried out to highlight invisible details in the original image; then, spectral signatures of representative areas were extracted and compared to Sentinel-2 data. At last, a classification analysis (ML and SAM) was performed both on PRISMA and Sentinel-2 imagery. The results showed a full agreement between Sentinel and PRISMA data, enhancing the capability of PRISMA in extrapolating more spectral information and providing a better reliability in the extraction of the features.
Urban Agglomeration Ecological Welfare Performance and Spatial Convergence Research in the Yellow River Basin
Authors: Liu Ningyi , Wang Yongyu
Published: November 2022

As human society is entering an era of scarce natural resources, realizing the welfare level of human society is a fundamental requirement to improve sustainable development, while being restrained by the ecological environment. In this paper, we divided ecological welfare performance (EWP) into an ecological economic system and an economic welfare system from the perspective of ecological welfare, and predicted the EWP in the Yellow River Basin Urban Agglomerations (YRBUAs) using the US-NSBM model in two stages. We further explored the dynamic change trend and spatial convergence characteristics in the YRBUAs using the Dagum Gini coefficient, the kernel density estimation method, and the spatial convergence models. The results indicate that there are great spatial variations in EWP in the YRBUAs, where the spatial variation in the downstream is higher than that in the upstream, and the spatial distribution pattern in large- and medium-sized cities is higher than that in small cities. The DEA efficiency could not be realized overall throughout the study period, but it shows an improving trend. At the same time, absolute β convergence and conditional β convergence were observed in the YRBUAs, both overall and between the UAs. This paper provides a basis for analyzing the spatial pattern of EWP and for promoting the coordinated development of urban agglomerations in the YRBUAs, thus serving as a reference for the sustainable development of ecologically sensitive regions in countries across the world.
Stakeholders’ Perceptions towards Land Restoration and Its Impacts on Ecosystem Services: A Case Study in the Chinese Loess Plateau
Authors: Chen Hao , Fleskens Luuk , Moolenaar Simon W. , Ritsema Coen J. , Wang Fei
Published: November 2022

To combat land degradation and deterioration issues, the Grain to Green project (GGP) was implemented on the Chinese Loess Plateau in 1999 and substantially altered the land cover by converting slope farmland into forest and grassland. To effectively achieve sustainable land restoration management and avoid stakeholder conflicts, this study aimed to understand how local stakeholders perceived the current land restoration process and expectations for future land restoration policy, as well as how stakeholders assessed the GGP impacts on local ecosystem service changes. We investigated the perspectives of 150 stakeholders representing five stakeholder groups including farmers, governmental officers, citizens, tourism operators and forestry practitioners using questionnaires administered in 2021 in the Yan’an area of the Chinese Loess Plateau. The survey results indicated a 72% support rate of stakeholders for the current GGP, with government officers reporting the highest value and tourism practitioners reporting the lowest. The support rate for future land restoration decreased to 51%. While majority of the stakeholders considered that the GGP had stimulated regulation and cultural ecosystem services, they also perceived negative impacts on grain production, livestock production, water yield and water quantity. Factors influencing farmers’ decision-making on recultivating the restored forest in the future were found to be economically driven. We recommend policy makers to improve the compensation standards and duration for farmers and increase the diversity of restoration tree species, and the involvement of participatory processes is suggested for future land restoration policy-making.
Effectiveness of Strategically Located Green Stormwater Infrastructure Networks for Adaptive Flood Mitigation in a Context of Climate Change
Authors: Muangsri Suphicha , McWilliam Wendy , Davies Tim , Lawson Gillian
Published: November 2022

Studies indicate Green Stormwater Infrastructure (GSI) on industrial land can provide substantial adaptive flood mitigation within urban catchments under climate change. To identify a cost-effective adaptive GSI network, planners need to evaluate flood mitigation capabilities of industrial properties through time and understand key characteristics informing when, where, and how GSI should be implemented for maximum effect. We applied the Hydrology-based Land Capability Assessment and Classification (HLCA+C) methodology to a catchment in Christchurch, New Zealand, to evaluate the capabilities of industrial properties clustered into Storm Water Management (SWM) zones under different climate change scenarios. SWM zone potentials and limitations were assessed to develop the most capable adaptive flood mitigation network with climate change. We prioritised six of twenty SWM zones for inclusion in the network based on their substantial flood mitigation capabilities. To maximise their capabilities through time, we orchestrated, and implemented GSI in zones incrementally, using different implementation approaches based on key characteristics determining their capability. The results indicated that the most capable zone could mitigate climate change-induced flooding, by itself, up to the end of this century under the moderate climate change scenario. However, if its capability was combined with that of five others, together they could mitigate flooding just shy of that associated with the major climate change scenario up to the end of this century. The resulting adaptive industrial GSI network not only provides substantial flood protection for communities but allows costly investments in flood mitigation structures, such as barriers and levees, to be safely delayed until their cost-effectiveness has been confirmed under increased climate certainty.
Factors in the Responsible Management of the Luna Valley Complex Geosite (NW Spain)—A Case Study
Authors: Fernández-Martínez Esperanza , Coronado Ismael , Adrados Luna , Castaño Rodrigo
Published: November 2022

The Luna Valley complex geosite (northwestern Spain) is a region of geoheritage significance located in an area with high environmental value. Geological studies began in the mid-20th century and continue to provide scientific data of significant relevance to the knowledge regarding the Palaeozoic stratigraphy of northern Gondwana and the tectonics of the Variscan orogen. This region also has high value for geoeducation, being visited regularly by both students and the general public. Educational use of the area has promoted the creation of several publicly available materials and activities that include trails, guides, displays and brochures, as well as the development of a small museum. However, over time, weathering; the abandonment of rural life; and the intensive, uncontrolled, and careless use of this region as a geosite for scientific and educational purposes has led to significant degradation and the consequent loss of its geoheritage value. This paper describes the geology of five key geosites in the Luna Valley. This is followed by a review of the promotional initiatives carried out in the area. These data, along with our knowledge of the area, allow us to develop a heritage analysis that includes the main geological interests, conservation status and some key management issues for each of these five individual sites. Several recommendations aim to control the physical degradation of the geosites, encourage their regular monitoring and the updating of the outreach materials using virtual tools, and promote the involvement of the local population in the conservation of this unique site.
Ecosystem Services Provided by Pastoral Husbandry: A Bibliometric Analysis
Authors: Mancilla-Leytón Juan Manuel , Gribis Djamila , Pozo-Campos Claudio , Morales-Jerrett Eduardo , Mena Yolanda , Cambrollé Jesús , Vicente Ángel Martín
Published: November 2022

The ecosystem services provided by the age-old activity of husbandry are presently declining or seriously endangered. The situation is particularly serious for regulation services and for certain cultural services given their growing dependence on external inputs. This work performs a bibliometric analysis for the purpose of identifying the certainties and gaps associated with the different ecosystems generated by pastoral husbandry, and confirms the pressing challenges that the livestock industry is facing in the current context of global change. Two different tools, Scopus and VOSviewer, have been implemented to analyze 2230 documents published between 1961 and 2021 that include the terms “grazing” and “service”. The information required for the bibliometric analysis of authorship, country of origin, field of study and number of citations, among other categories, was drawn from the documents to the effect of evidencing their general thematic relationships. Finally, the current state of the ecosystem services currently provided by pastoral husbandry—provisioning, regulation, cultural and support services—was assessed. The results showed a greater abundance of scientific literature on provisioning and regulation services than on cultural and support services. An increase in the number of publications from the beginning of the 21st century was confirmed. The United States stands out as the country with the largest scientific production, and environmental sciences is the most prominent field in the study of ecosystem services. A recent larger academic effort to encourage the promotion of ecosystem services from the institutions has also been observed, as well as to include them as a factor in the development of environmental policies, which is described as the greatest challenge for the future of this discipline. Among other possible solutions, the new European Union agricultural subsidies—the so-called eco-schemes—appear to be essential for that effort to bear fruit as soon as possible.
Spatial Correlation and Influencing Factors of Tourism Eco-Efficiency in the Urban Agglomeration of the Yangtze River Delta Based on Social Network Analysis
Authors: Wang Yuewei , An Lidan , Chen Hang , Zhao Yuyan
Published: November 2022

Tourism eco-efficiency analysis is an effective tool to solve the problem of sustainable tourism development. The tourism eco-efficiency evaluation index system was constructed in the study, and the undesirable output super-slacks-based measure model was used to estimate the tourism eco-efficiency of 26 cities in the Yangtze River Delta. Then, the modified gravity model based on the values of the tourism eco-efficiency analysis of each city was used to construct a spatial correlation network. The structural characteristics of the spatial association networks of tourism eco-efficiency, the interrelationships among different cities, and the roles played by different blocks were explored using a social network analysis. The quadratic assignment procedure (QAP) was applied to analyze the influencing factors that affect the formation of the spatial association network of tourism eco-efficiency. The results show that tourism eco-efficiency has an overall increasing trend, and the gap among cities is decreasing. The structure of the spatial correlation network of tourism eco-efficiency has good connectivity, accessibility, and robustness with the correlations among all of the cities in the network. The spillover effects among the blocks are significant, showing spatial polarization, with the cities such as Shanghai, Suzhou, and Hangzhou occupying the core position of the network. The QAP analysis shows that the spatial correlation network of tourism eco-efficiency is affected by the distance between the cities and the levels of development of the economy and information dissemination. The results of this study innovatively reveal the structural characteristics and influencing factors of the spatial correlation network of tourism eco-efficiency. It could provide valuable insights for the development of corresponding policy measures by government sectors and tourism firms to enhance the sustainability of regional tourism development.
Fractal Features of Soil Particles as an Indicator of Land Degradation under Different Types of Land Use at the Watershed Scale in Southern Iran
Authors: Tahmoures Mohammad , Honarbakhsh Afshin , Afzali Sayed Fakhreddin , Abotaleb Mostafa , Ingram Ben , Ostovari Yaser
Published: November 2022

Soil particle-size distribution (PSD) is an important soil feature that is associated with soil erosion, soil fertility, and soil physical and chemical properties. However, very few studies have been carried out to investigate soil degradation using the fractal dimension (D) of the PSD of soils from different land-use types in the calcareous soil of Iran. For this study, 120 soil samples (0–20 cm) were collected from different land-use types in the Fars Province, and various basic soil properties such as soil organic matter (SOM), soil texture fractions, calcium carbonate (CaCO3), pH, and cation-exchange capacity (CEC) were measured. The PSD of the soil samples was determined using the international classification system for soil size fraction, and the D of the PSD was calculated for all soils. The results of this study show that D is significantly correlated with clay content (r = 0.93) followed by sand content (r = −0.54) and CEC (r = 0.51). The mean D values of the forest areas (D = 2.931), with a SOM content of 2.1%, are significantly higher than those of the agricultural land (D = 2.905 and SOM = 1.6%) and pastures (D = 2.910 and SOM = 1.6%), indicating that fine soil particles, particularly clay, have been preserved in forest soils but lost in agricultural and pasture soils. We conclude that agricultural land has experienced significantly higher levels of soil erosion than forest areas.
Exploiting Plant–Phytonematode Interactions to Upgrade Safe and Effective Nematode Control
Authors: Abd-Elgawad Mahfouz M. M.
Published: November 2022

Plant-parasitic nematodes (PPNs) bring about substantial losses of economic crops globally. With the environmental and health issues facing the use of chemical nematicides, research efforts should focus on providing economically effective and safe control methods. The sound exploitation of plant-PPN interactions is fundamental to such efforts. Initially, proper sampling and extraction techniques should be followed to avoid misleading nematode data. Recent evolutions in plant-PPN interactions can make use of diverse non-molecular and molecular approaches to boost plant defenses. Therefore, PPN control and increasing crop yields through single, sequential, dual-purpose, and simultaneous applications of agricultural inputs, including biocontrol agents, should be seriously attempted, especially within IPM schemes. The use of biologicals would ideally be facilitated by production practices to solve related issues. The full investment of such interactions should employ new views of interdisciplinary specialties in the relevant modern disciplines to optimize the PPN management. Having an accurate grasp of the related molecular events will help in developing tools for PPN control. Nonetheless, the currently investigated molecular plant-PPN interactions favoring plant responses, e.g., resistance genes, RNA interference, marker-assisted selection, proteinase inhibitors, chemo-disruptive peptides, and plant-incorporated protectants, are key factors to expanding reliable management. They may be applied on broader scales for a substantial improvement in crop yields.
Clinical Efficacy of an Electronic Portal Imaging Device versus a Physical Phantom Tool for Patient-Specific Quality Assurance
Authors: Baek Seung-Hyeop , Choi Sang-Hyoun , Han Moo-Jae , Cho Gyu-Seok , Jang Wonil , Kim Jin-Sung , Kim Kum-Bae
Published: November 2022

Pre-treatment patient-specific quality assurance (QA) is critical to prevent radiation accidents. The electronic portal imaging device (EPID) is a dose measurement tool with good resolution and a low volume-averaging effect. EPIbeam—an EPID-based portal dosimetry software—has been newly installed in three institutions in Korea. This study evaluated the efficacy of the EPID-based patient-specific QA tool versus the PTW729 detector (a previously used QA tool) based on gamma criteria and planning target volume (PTV). A significant difference was confirmed through the R statistical analysis software. The average gamma passing rates of PTW729 and EPIbeam were 98.73% and 99.60% on 3 mm/3% (local), 96.66% and 97.91% on 2 mm/2% (local), and 88.41% and 74.87% on 1 mm/1% (local), respectively. The p-values between them were 0.015 (3 mm/3%, local), 0.084 (2 mm/2%, local), and less than 0.01 (1 mm/1%, local). Further, the average gamma passing rates of PTW 729 and EPIbeam according to PTV size were 99.55% and 99.91% (PTV < 150 cm3) and 97.91% and 99.28% (PTV > 150 cm3), respectively. The p-values between them were 0.087 (PTV < 150 cm3) and 0.036 (PTV > 150 cm3). These results confirm that EPIbeam can be an effective patient-specific QA tool.
Effects of Different Corticosteroid Doses in Elderly Unvaccinated Patients with Severe to Critical COVID-19
Authors: Scialò Filippo , Mariniello Domenica , Nigro Ersilia , Komici Klara , Allocca Valentino , Bianco Andrea , Perrotta Fabio , D’Agnano Vito
Published: November 2022

SARS-CoV-2 infection can induce a broad range of clinical symptoms, and the most severe cases are characterized by an uncontrolled inflammatory response with the overproduction of proinflammatory cytokines. Elevated levels of C-reactive protein, interleukin-1B, and interleukin-6 have become key signatures of severe COVID-19. For this reason, the use of 6 mg of dexamethasone has become a standard of care, although this regime may not be optimal. Even though various glucocorticoid doses have been proposed, it is still unclear which dose should be used to prevent adverse effects while at the same time reducing the inflammatory response. Here, we compared two different doses of corticosteroids in 52 elderly hospitalized patients with severe to critical COVID-19 to assess efficacy and safety. We showed that in patients receiving a higher dose of prednisone, the time to negative swab was significantly longer. Furthermore, although neither dose was correlated with the risk of death, patients receiving the high dose were more likely to have adverse events such as hyperglycemia, leukocytosis, an increase in systemic blood pressure, and others. Finally, the BMI, WBC number, and NLR value were directly related to death. In conclusion, although the optimal glucocorticoid dose is still undefined, our retrospective study supports the absence of beneficial effects in the utilization of higher doses of corticosteroids in elderly patients with severe to critical COVID-19.
Network Pharmacology and Experimental Validation to Investigate the Antidepressant Potential of Atractylodes lancea (Thunb.) DC.
Authors: Nguyen Ly Thi Huong , Nguyen Nhi Phuc Khanh , Tran Khoa Nguyen , Shin Heung-Mook , Yang In-Jun
Published: November 2022

Atractylodes lancea (Thunb.) DC. (AL) has been indicated in traditional prescriptions for the treatment of depression. However, the mechanism of action of AL in the treatment of depression is still unclear. This study aimed to investigate the antidepressant potential of AL using network pharmacology, molecular docking, and animal experiments. The active components of AL were retrieved from the traditional Chinese medicine systems pharmacology database and analysis platform (TCMSP), and the depression-related targets were screened through the DisGeNET database. Overlapping targets of AL and depression were selected and analyzed. Ten active compounds of AL showed anti-depressant potential, including stigmasterol, 3β-acetoxyatractylone, wogonin, β-sitosterol, selina-4(14),7(11)-dien-8-one, atractylenolide I, atractylenolide II, atractylenolide III, patchoulene, and cyperene. These compounds target 28 potential antidepressant genes/proteins. Gene Ontology (GO) enrichment analysis revealed that the potential targets might directly influence neural cells and regulate neuroinflammation and neurotransmitter-related processes. The potential Kyoto Encyclopedia Genes and Genomes (KEGG) pathways for the antidepressant effects of AL include neuroactive ligand–receptor interactions, calcium signaling pathways, dopaminergic synapse, interleukin (IL)-17 signaling pathways, and the pathways of neurodegeneration. IL-6, nitric oxide synthase 3 (NOS), solute carrier family 6 member 4 (SLC6A4), estrogen receptor (ESR1), and tumor necrosis factor (TNF) were the most important proteins in the protein–protein interaction network and these proteins showed high binding affinities with the corresponding AL compounds. AL showed an antidepressant effect in mice by decreasing immobility time in the tail suspension test and increasing the total contact number in the social interaction test. This study demonstrated the antidepressant potential of AL, which provides evidence for pursuing further studies to develop a novel antidepressant.
Clampless In-Situ Immobilized Branching (CLIMB) to Reconstruct the Internal Iliac Artery
Authors: Shirasu Takuro , Akai Atsushi , Motoki Manabu , Kato Masaaki
Published: November 2022

Background: Surgical reconstruction of the internal iliac artery (IIA) or its branches is sometimes demanding because of difficulty in distal clamping and suturing in the narrow pelvic space. Here we present a hybrid technique of ClampLess In-situ imMobilized Branching (CLIMB) to reconstruct IIA. Methods: in the CLIMB technique, an 8 mm artificial graft is sutured onto the surface of the common iliac artery (CIA) without clamping. Following puncture of the CIA wall, stent grafts are bridged from IIA to the graft. Finally, the graft is sutured to the ipsilateral external iliac artery (EIA). Concomitant endovascular aneurysm repair or IIA branch embolization can also be performed. We applied this technique to the patients unsuited for other IIA reconstruction. Results: eleven patients underwent the current technique. All but one patient underwent contralateral IIA interruption. Seven patients had a history of aorto-iliac repair before the index surgery. Iliac extender, internal iliac component, Viabahn VBX or Fluency covered stent were used for bridging the graft. Simultaneous IIA branch embolization was performed in 2 patients. Distal landing zones were IIA in 7 grafts, superior gluteal artery in 4 grafts and inferior gluteal artery (IGA) in 1 graft. Technical success was achieved in all cases. No patient complained of buttock claudication or other ischemic symptoms on the treatment side. During a mean follow-up period of 38 months, 11 out of 12 grafts were patent without any related endoleak. One IGA graft occluded at 56 months after surgery. Conclusions: the CLIMB technique is a viable alternative to preserve IIA with an acceptable mid-term durability.
Effects of Salt Stress on the Antioxidant Activity and Malondialdehyde, Solution Protein, Proline, and Chlorophyll Contents of Three Malus Species
Authors: Wang Dajiang , Gao Yuan , Sun Simiao , Lu Xiang , Li Qingshan , Li Lianwen , Wang Kun , Liu Jihong
Published: November 2022

Understanding the different physiological responses of Malus species under salt stress in the seedling stages will be useful in breeding salt-tolerant dwarfing apple rootstocks. Seedlings of Malus Zumi (Mats.) Rehd. (M. zumi), Malus sieversii (Led.) Roem. (M. sieversii), and Malus baccata (L.) Borkh. (M. baccata) were treated with solution of 0, 0.20%, 0.40%, and 0.60% salinity. Physiological parameters of their leaves and roots were measured at 0 d, 4 d, 8 d and 12 d after salinity treatments. Superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), malondialdehyde (MDA), solution protein (SP), and proline (PRO) initially increased and then decreased. The activities and contents of these parameters were higher in the 0.40% and 0.60% NaCl treatments than in the 0.20% treatment and in the 0% control. M. zumi was the most resistant to salt stress, showing the lowest content of MDA in the leaves and roots, which increased slightly under salt stress. M. baccata had the highest increase in both the content and proportion of MDA. High enzyme activity was shown to play an important role in the salt resistance of M. zumi. Moreover, it can be speculated that there are other substances that also play a major role. We found that osmotic regulation played a key role in response to salt stress for M. baccata even though it was sensitive to salt stress. For M. sieversii, both the osmotic regulation and enzymatic antioxidants were observed to play a major role in mitigating salt stress.
Efficacy of Topical Administration of Corticosteroids for the Management of Dry Eye Disease: Systematic Review and Meta-Analysis
Authors: Prinz Julia , Maffulli Nicola , Fuest Matthias , Walter Peter , Bell Andreas , Migliorini Filippo
Published: November 2022

The efficacy of corticosteroids (CS) for dry eye disease (DED) has been investigated in the clinical setting. The present study investigated whether topical CS application improves the clinical outcome at last follow-up compared to the baseline. The present study was conducted according to the PRISMA 2020. All the randomized clinical trials (RCTs), which investigated the efficacy of corticosteroids in the management of DED, were accessed. In September 2022, the following databases were accessed: Pubmed, Web of Science, Google Scholar, and Embase. The following data were extracted at baseline and at last follow-up: Ocular Surface Disease Index (OSDI), tear breakup time test (TBUT), Schirmer I test (SIT), and corneal staining. Data from 425 patients were retrieved. A total of 69.4% (295 of 425 patients) were women. CS were effective to improve SIT (p = 0.02) and corneal staining (p = 0.003) at the last follow-up of 10.0 ± 15.3 weeks. TBUT was greater in the CS than in the control group at the last follow-up (p = 0.002). Concluding, topical CS administration led to an increase of SIT and a reduction of corneal staining at a mean of 10 weeks follow-up in patients with DED. Compared to a control group, topical CS administration evidenced greater values of TBUT. Altogether, a good safety profile was witnessed in DED patients receiving CS. However, different safety profiles of different CS formulations were not investigated due to a lack of quantitative data. The exact dosing frequency, duration of therapy, and favorable potency of the CS are still under investigation. Future randomized, controlled trials with larger sample sizes are warranted to provide higher-quality evidence to establish the role of CS in DED.