bluuebunny/crossref_metadata_2025 huggingface dataset:
Experimental Validation of a New Antivibration Elastomeric Material Fabricated from End-of-Life Tires for Slab Track Systems with Embedded Rail
Authors: Gómez Jorge , Casado José Antonio , Carrascal Isidro A. , Diego Soraya , Ferreño Diego , Mondragón Catalina
Published: July 2019

This article is focused on the experimental characterization and validation of a novel elastomeric material fabricated from the grinded end-of-life tires blended with polyurethane resin. This material will be used as a vibration and noise attenuator in railway slab track systems with embedded rail, commonly used in urban areas. Cylinders with different combinations of grain sizes (coarse, medium, and fine) of end-of-life tires and contents of resin were mechanically tested to obtain the Young’s modulus. The most versatile combination consisting in 50 % coarse + 50 % medium size grains was selected. Two real-scale prototypes consisting of a rail surrounded by the rubber mixture and the concrete slab were designed and fabricated to be applied under normal conditions (low attenuation system) and under situations where vibrations could be fatal (high attenuation system). These prototypes were subjected to static, dynamic, and fatigue loading conditions, applying vertical and angular loads, to validate their mechanical performance. In addition, a vibroacustical experimental study was carried out to obtain the frequency response and the receptance functions. A one-degree-of-freedom analytical model was developed to obtain a loss factor η = 0.287 and a vibration attenuation capacity of the system for the human ear peak sensitivity of ∼40 dB. This study proves the validation of this new eco-friendly material to be used as a vibration attenuator for railway traffic.
Discrete Element Methods for Characterizing the Elastic Behavior of the Granular Particles
Authors: Ding Xunhao , Ma Tao , Gu Linhao , Zhang Deyu , Huang Xiaoming
Published: July 2019

Focusing on characterizing the elastic behavior of the granular particles based on the discrete element method (DEM), this study utilized the Mustoe and Griffiths’ equations and a homogenization method to predict the performance of the continuous elastic medium precisely, including the elastic modulus, Poisson’s ratio, and the brittle fracture criterion. A commercial DEM software named Particle Flow Code in Two Dimensions (PFC2D) was used to conduct the numerical simulations because the macrobehavior predicted by the PFC2D highly depends on the sphere size and arrangements. The hexagonal parking arrangements were applied further herein for better theoretical calculations. With the combined analysis of the discontinuum theory and continuum theory, the DEM parameters were determined theoretically and were verified based on the virtual compression and tension tests. The factors (including sphere size, stiffness ratios, etc.) influencing the prediction accuracy were also analyzed further. The results showed that by the parameter determination methods proposed in this study, the behavior of the continuous elastic medium could be well characterized.
Developments of Conductive Materials and Characteristics on Asphalt Concrete: A Review
Authors: Chen Zheng , Liu Ruonan , Hao Peiwen , Li Guoxin , Su Jian
Published: July 2019

The requirements for modified asphalt concrete are increasing because of heavy traffic load and worsening service environments in modern highway construction. More and more attention has been paid to the development of multifunctional asphalt concrete. Conductive asphalt concrete exhibits specific characteristics and incredible novel features, such as self-diagnosis and monitoring, self-healing, and snowmelt, etc. It has the potential to satisfy multifunctional applications. This article summarizes the major achievements of the existing literatures about conductive asphalt concrete, including material design, mechanism analysis, performance evaluation and engineering applications, and gives some proposals for further investigations. The article shows that the conductivity and mechanical properties of conductive asphalt concrete are strongly dependent on the compositions of the material. Meanwhile, the mechanism of conductivity improvement is identified according to the characteristics of conductive additives. Although conductive asphalt concrete has some shortcomings and few applications in the highway industry, it shows some appreciable advantages in aspects such as environment protection and traffic safety. The purpose of this review article is to provide the reference and guidance for researchers to discover proper material design, novel properties, durability, and desirable high operational efficiency, as well as suitable construction technique.
Buenas Vecinas?
Authors: Ehrick Christine
Published: July 2019

During World War II, US–Latin American relations were shaped by the noninterventionist Good Neighbor policy and the projection of soft power via US government-orchestrated public relations and propaganda campaigns. This included extensive film and radio propaganda overseen by the US Office of Inter-American Affairs (OIAA) and disseminated throughout the region. One dimension of that campaign involved radio propaganda aimed specifically at women, who were regaled with stories of heroic Latin American women and carefully curated female perspectives on life in the United States during wartime. In much of this material, the United States was presented as a dominant yet gentlemanly hemispheric partner, offering Latin America protection and material abundance in exchange for loyalty and deference. As the war wound down, such propaganda took a sharp turn toward the Cold War, when Good Neighbor chivalry gave way to more strident rhetoric, prefiguring a return to US interventionist politics of the prewar era.
Vulnerabilidade clínica e funcional de idosos cuidadores de idosos com doença de Alzheimer
Authors: Barbosa Maria Emilia Marcondes , Bertelli Ellen Vanusa Martins , Scolari Giovana Aparecida de Souza , Bortolanza Marciane Conti Zornita , Higarashi Ieda Harumi , Carreira Lígia
Published: July 2019

Objetivo: avaliar a vulnerabilidade clínica e funcional de idosos cuidadores de idosos com Alzheimer. Métodos: estudo transversal, realizada com idosos cuidadores, cadastrados em Associação de Assistência a Doente de Alzheimer. Utilizou-se de questionário sociodemográfico e do Índice de Vulnerabilidade Clínico-Funcional-20 itens, para coleta de dados, os quais foram analisados por meio do software R, utilizando-se de porcentagem, correlação de Spearman e D de Somer. Resultados: participaram 31 idosos cuidadores, maioria mulheres, com idades entre 60 e 74 anos, casadas, baixa escolaridade e que prestavam cuidado ao cônjuge. Identificou-se maior risco de vulnerabilidade relacionada à autopercepção de saúde, cognição e humor. Funcionalidade preservada nas funções executivas, comunicação, mobilidade e comorbidades múltiplas. Conclusão: a maioria dos idosos cuidadores apresentou risco de fragilização, porém realizam o cuidado ao familiar com Alzheimer. Profissionais e instituições devem atuar na prevenção do declínio funcional desses cuidadores idosos.
Maximum principle for a nonlinear size-structured model of fish and fry management
Authors: Liu Rong , Liu Guirong
Published: July 2019

This paper investigates the maximum principle for a nonlinear size-structured model that describes the optimal management of the fish resources taking into account harvesting the fish and putting the fry. We establish the well-posedness of the state system by Banach fixed-point theorem. Necessary conditions for optimality are established via the normal cone technique and adjoint system. The existence of a unique optimal policy is proved via Ekeland's variational principle and fixed-point reasoning. Finally, some examples and numerical results demonstrate the effectiveness of the theoretical results in our paper.
Housing Instability Among Families With Young Children With Special Health Care Needs
Authors: Rose-Jacobs Ruth , Ettinger de Cuba Stephanie , Bovell-Ammon Allison , Black Maureen M. , Coleman Sharon M. , Cutts Diana , Chilton Mariana , Heeren Timothy , Casey Patrick , Ochoa Eduardo , Frank Deborah A. , Sandel Megan
Published: July 2019

BACKGROUND AND OBJECTIVE:

Children with special health care needs (SHCNs) have significant medical and educational expenses affecting household finances. Housing instability can be detrimental to family well-being. Our objective was to evaluate housing instability in households of children with and without SHCNs.

METHODS:

Cross-sectional surveys (2013–2017) in English and Spanish of caregivers with children <4 years old were conducted at 5 hospitals. The children with SHCN screener and caregiver report of child Supplemental Security Income (SSI) receipt were used to categorize children into the following groups: (1) no SHCNs, (2) SHCNs and no SSI, or (3) SHCNs and receiving SSI. Housing instability was determined by positive endorsement of ≥1 adverse circumstance: behind on rent or mortgage, or moving twice or more in the past year, or homelessness in the child’s lifetime. Analyses used multivariable logistic regression models, adjusting for demographics and housing subsidies.

RESULTS:

Of 14 188 children, 80% had no SHCNs, 16% had SHCNs and no SSI, and 4% had SHCNs and received SSI. Compared with the no-SHCNs group, the SHCNs–no-SSI group but not the SHCN–receiving-SSI group experienced significantly greater adjusted odds of being behind on rent or mortgage (adjusted odds ratio [aOR] 1.28 [95% confidence interval (CI) 1.14–1.44]; P < .001), multiple moves (aOR 1.29 [95% CI 1.05–1.59]; P = .01), and homelessness (aOR 1.44 [95% CI 1.20–1.72]; P < .001).

CONCLUSIONS:

Families of children with SHCNs are at risk for housing instability. Child SSI receipt decreased the risk of housing instability among families of children with SHCNs. Protecting families of young children with SHCNs from housing instability is an important investment.
Office-Based Educational Handout for Influenza Vaccination: A Randomized Controlled Trial
Authors: Scott Vanessa P. , Opel Douglas J. , Reifler Jason , Rikin Sharon , Pethe Kalpana , Barrett Angela , Stockwell Melissa S.
Published: July 2019

OBJECTIVES:

To assess the impact of a parent educational intervention about influenza disease on child vaccine receipt.

METHODS:

A convenience sample of parents of children ≥6 months old with a visit at 2 New York City pediatric clinics between August 2016 and March 2017 were randomly assigned (1:1:1) to receive either usual care, an educational handout about influenza disease that was based on local data, or an educational handout about influenza disease that was based on national data. Parents received the handout in the waiting room before their visit. Primary outcomes were child influenza vaccine receipt on the day of the clinic visit and by the end of the season. A multivariable logistic regression was used to assess associations between intervention and vaccination, with adjustment for variables that were significantly different between arms.

RESULTS:

Parents who received an intervention (versus usual care) had greater odds of child influenza vaccine receipt by the end of the season (74.9% vs 65.4%; adjusted odds ratio 1.68; 95% confidence interval: 1.06–2.67) but not on the day of the clinic visit. Parents who received the national data handout (versus usual care) had greater odds of child influenza vaccine receipt on the day of the clinic visit (59.0% vs 52.6%; adjusted odds ratio 1.79; 95% confidence interval: 1.04–3.08) but not by the end of the season.

CONCLUSIONS:

Providing an educational intervention in the waiting room before a pediatric provider visit may help increase child influenza vaccine receipt.
Eigenstructure for binomial operators*
Authors: Wang Shifen , Zhang Chungou
Published: July 2019

In this article, the eigenvalues and eigenvectors of positive binomial operators are presented. The results generalize the previously obtained ones related to Bernstein operators. Illustrative examples are supplied.
Commutators of sublinear operators in grand morrey spaces
Authors: Kokilashvili Vakhtang , Meskhi Alexander , Rafeiro Humberto
Published: July 2019

In this paper we establish the boundedness of commutators of sublinear operators in weighted grand Morrey spaces. The sublinear operators under consideration contain integral operators such as Hardy-Littlewood and fractional maximal operators, Calderón-Zygmund operators, potential operators etc. The operators and spaces are defined on quasi-metric measure spaces with doubling measure.
Almost sure central limit theorems for weighted dependent sequences
Authors: Gonchigdanzan Khurelbaatar
Published: July 2019

Let {Xn: n ≧ 1} be a sequence of dependent random variables and let {wnk: 1 ≦ k ≦ n, n ≧ 1} be a triangular array of real numbers. We prove the almost sure version of the CLT proved by Peligrad and Utev [7] for weighted partial sums of mixing and associated sequences of random variables, i.e.
Groups with restrictions on proper uncountable subgroups
Authors: De Giovanni Francesco , Trombetti Marco
Published: July 2019

A group G is called metahamiltonian if all its non-abelian subgroups are normal. The aim of this paper is to investigate the structure of uncountable groups of cardinality ℵ in which all proper subgroups of cardinality ℵ are metahamiltonian. It is proved that such a group is metahamiltonian, provided that it has no simple homomorphic images of cardinality ℵ. Furthermore, the behaviour of elements of finite order in uncountable groups is studied in the second part of the paper.
Disciplinary positioning struggles
Authors: Hah Sixian
Published: July 2019

With no existing panel for applied linguistics at the last Research Excellence Framework (REF) in 2014, academics working in this field in the UK struggle to position their work and themselves as researchers. Yet, gaining recognition for one's expertise and positioning oneself in disciplinary terms are rites of passage for all academic researchers. This paper agues that disciplines, rather than being clearly defined and static areas of knowledge, are instead constituted and demarcated through the enactment of discursive practices. Focusing on qualitative research interviews with three early career academics out of a corpus of 30 interviews with academics from various career stages, and informed by ideas from Bakhtinian polyphony and positioning theory, I demonstrate how these academics often resist positions imposed on them by unnamed voices in larger discourses which constitute mainstream expectations about academia. The findings highlight how respondents’ struggles to position their research relate to changing institutional demands in the current climate of higher education in the UK. This paper also contributes to our understanding of disciplinary positioning as enacted through the qualitative research interview.
The Impact of Scientific and Technological Progress on the Banking Sector Economic Security
Authors: Budovich Yuliya , Ryzhova Irina
Published: July 2019

The impact of scientific and technological progress is global and ubiquitous. It is used to digitize society and complicate economic processes. Although the impact of scientific and technological progress on the development of society is currently highly appreciated, it is not easy to assess its impact on individual sectors. At the same time, it carries new risks and threats the economy of any country constantly deals with. The economy of Russia, as well as the economies of other developed countries, is subject to global changes. Each of its areas is permeated with scientific and technological progress. The Russian banking sector is also under its influence. The modern Russian banking sector is undergoing rapid digitalization of banking procedures. Positive effects of this activity are noted. However, digitalization is a controversial and long process. On the one hand, transaction costs are decreasing, on the other hand, new threats that increase risks are emerging. In addition, scientific and technological progress affects not only interbank procedures and protocols, but also interbank relations. Besides, changes within the banking sector have a direct impact on the socio-economic situation of citizens. The article considers the external and internal threats affecting the banking sector security and reveals causal relationships of their origin. The authors also propose measures to improve the banking sector economic security.
The Issues of the Formation of the Common Economic Interest in the Russian Economic System
Authors: Tsikin Aleksej
Published: July 2019

The article is devoted to studying the theory of economic interests on the basis of the retrospective analysis of the works of the main economic school representatives, modern Russian and foreign scientists. The aim of the work is to elaborate the concept of the common economic interest in the modern Russian economic system. To achieve this aim, the author conducted the development analysis of the relevant methodological approaches to the study of economic relations, identified the most relevant concepts and proposed the concept interpretations of the national economic system priorities. It is established that the evolution of the theory of economic interests is directly related to the world economy development. In the current conditions, approaches related to absolutization of state (characteristic of the Late Middle Ages) or private (used during the rapid development of the market) interests are not applicable to achieve the common economic interest. Today, the theory introduces the factors of uncertainty, limited knowledge, explores real and perceived interests, and increases the role of social security and environmental safety. The analysis carried out in the work indicates the need to include social, innovative, technological, labor, infrastructure, institutional priorities, as well as self-sufficiency of the economy in the definition of the common economic interest. The results of the work can be used in developing strategies to improve the competitiveness of the Russian economy.
Fracture Risk in Women with Breast Cancer Initiating Aromatase Inhibitor Therapy: A Registry-Based Cohort Study
Authors: Leslie William D. , Morin Suzanne N. , Lix Lisa M. , Niraula Saroj , McCloskey Eugene V. , Johansson Helena , Harvey Nicholas C. , Kanis John A.
Published: July 2019

Background

Aromatase inhibitors (AIs) used in breast cancer induce loss in bone mineral density (BMD) and are reported to increase fracture risk.

Materials and Methods

Using a population-based BMD registry, we identified women aged at least 40 years initiating AIs for breast cancer with at least 12 months of AI exposure (n = 1,775), women with breast cancer not receiving AIs (n = 1,016), and women from the general population (n = 34,205). Fracture outcomes were assessed to March 31, 2017 (mean, 6.2 years for AI users).

Results

At baseline, AI users had higher body mass index (BMI), higher BMD, lower osteoporosis prevalence, and fewer prior fractures than women from the general population or women with breast cancer without AI use (all p < .001). After adjusting for all covariates, AI users were not at significantly greater risk for major osteoporotic fractures (hazard ratio [HR], 1.15; 95% confidence interval [CI], 0.93–1.42), hip fracture (HR, 0.90; 95% CI, 0.56–1.43), or any fracture (HR, 1.06; 95% CI, 0.88–1.28) compared with the general population.

Conclusion

Higher baseline BMI, BMD, and lower prevalence of prior fracture at baseline may offset the adverse effects of AI exposure. Although confirmatory data from large cohort studies are required, our findings challenge the view that all women with breast cancer initiating AI therapy should be considered at high risk for fractures.

Implications for Practice

In a population-based observational registry that included 1,775 patients initiating long-term aromatase inhibitor therapy, risk for major osteoporotic fracture, hip fracture, or any fracture was similar to the general population. Higher baseline body mass index, bone mineral density, and lower prevalence of prior fracture at baseline may offset the adverse effects of aromatase inhibitor exposure.
Cumulative Antibiotic Use Significantly Decreases Efficacy of Checkpoint Inhibitors in Patients with Advanced Cancer
Authors: Tinsley Nadina , Zhou Cong , Tan Grace , Rack Samuel , Lorigan Paul , Blackhall Fiona , Krebs Matthew , Carter Louise , Thistlethwaite Fiona , Graham Donna , Cook Natalie
Published: July 2019

Background

With the advent of immunotherapy, substantial progress has been made in improving outcomes for patients with advanced cancer. However, not all patients benefit equally from treatment, and confounding immune-related issues may have an impact. Several studies suggest that antibiotic use (which alters the gut microbiome) may result in poorer outcomes for patients treated with immune checkpoint inhibitors (ICI).

Materials and Methods

This is a large, single-site retrospective review of n = 291 patients with advanced cancer treated with ICI (n = 179 melanoma, n = 64 non-small cell lung cancer, and n = 48 renal cell carcinoma). Antibiotic use (both single and multiple courses/prolonged use) during the periods 2 weeks before and 6 weeks after ICI treatment was investigated.

Results

Within this cohort, 92 patients (32%) received antibiotics. Patients who did not require antibiotics had the longest median progression-free survival (PFS), of 6.3 months, and longest median overall survival (OS), of 21.7 months. With other clinically relevant factors controlled, patients who received a single course of antibiotics had a shorter median OS (median OS, 17.7 months; p = .294), and patients who received multiple courses or prolonged antibiotic treatment had the worst outcomes overall (median OS, 6.3 months; p = .009). Progression-free survival times were similarly affected.

Conclusion

This large, multivariate analysis demonstrated that antibiotic use is an independent negative predictor of PFS and OS in patients with advanced cancer treated with ICIs. This study highlighted worse treatment outcomes from patients with cumulative (multiple or prolonged courses) antibiotic use, which warrants further investigation and may subsequently inform clinical practice guidelines advocating careful use of antibiotics.
Combined Microsatellite Instability and Elevated Microsatellite Alterations at Selected Tetranucleotide Repeats (EMAST) Might Be a More Promising Immune Biomarker in Colorectal Cancer
Authors: Chen Ming-Huang , Chang Shih-Ching , Lin Pei-Ching , Yang Shung-Haur , Lin Chun-Chi , Lan Yuan-Tzu , Lin Hung-Hsin , Lin Chien-Hsing , Lai Jiun-I , Liang Wen-Yi , Lu Meng-Lun , Yang Muh-Hwa , Chao Yee
Published: July 2019

Background

The form of microsatellite instability (MSI) affecting tetranucleotide repeats known as elevated microsatellite alterations at selected tetranucleotide repeats (EMAST) has emerged as a new potential biomarker in multiple cancers. In colorectal cancer (CRC), the correlation between EMAST and MSI mutations remain inconclusive.

Materials and Methods

We evaluated 1,505 patients with CRC using five EMAST markers (D20S82, D20S85, D8S321, D9S242, and MYCL1) and the Bethesda panel of MSI markers. Most commonly, mutations involved in CRCs were identified by MassArray Assay, and DNA repair genes were analyzed by next-generation sequencing. Clinical characteristics and prognostic relevance were correlated with EMAST and MSI.

Results

Tumors that were EMAST positive and MSI high (MSI-H) were detected in 159 (10.6%) and 154 (10.2%) of 1,505 patients with CRC. Patients were divided into four groups according to EMAST and MSI status (EMAST-positive and MSI-H, EMAST-positive and microsatellite-stable [MSS], EMAST-negative and MSI-H, and EMAST-negative and MSS). The EMAST-positive and MSI-H group was associated with female predominance, higher prevalence of proximal colon tumors, early stage tumors, poorly differentiated tumors, mucinous histology, and higher incidence of mutations in PI3KCA, BRAF, TGFBR, PTEN, and AKT1 compared with other groups. Furthermore, compared with only EMAST-positive tumors or only MSI-H tumors, tumors that were both EMAST-positive and MSI-H had a higher frequency of MLH1, MSH3, MSH6, PMS2, and EXO1 gene mutations. Finally, the presence of EMAST-positive and MSI-H tumors was a good prognostic indicator in CRC.

Conclusion

High mutations in several DNA repair genes in EMAST-positive and MSI-H tumors suggest that this subtype of CRC might be more suitable for treatment with immune therapy.

Implications for Practice

Elevated microsatellite alterations at selected tetranucleotide repeats (EMAST) is a unique molecular subtype of colorectal cancer (CRC). The current study demonstrated that the EMAST-positive and MSI-high (MSI-H) group was associated with female predominance, higher prevalence of proximal colon tumors, early stage tumors, poorly differentiated tumors, mucinous histology, and higher incidence of mutations in PI3KCA, BRAF, TGFBR, PTEN, and AKT1 compared with other groups. Most importantly, high mutations in DNA repair genes and MSI-related genes in EMAST-positive and MSI-H tumors suggest that this subtype of CRC might be more suitable for treatment with immune therapy compared with MSI-H tumors alone.
Evaluating Glomerular Filtration Rate Slope as a Surrogate End Point for ESKD in Clinical Trials: An Individual Participant Meta-Analysis of Observational Data
Authors: Grams Morgan E. , Sang Yingying , Ballew Shoshana H. , Matsushita Kunihiro , Astor Brad C. , Carrero Juan Jesus , Chang Alex R. , Inker Lesley A. , Kenealy Timothy , Kovesdy Csaba P. , Lee Brian J. , Levin Adeera , Naimark David , Pena Michelle J. , Schold Jesse D. , Shalev Varda , Wetzels Jack F. M. , Woodward Mark , Gansevoort Ron T. , Levey Andrew S. , Coresh Josef
Published: July 2019

Significance Statement

Randomized clinical trials of treatments to slow CKD progression often require large sample sizes and long follow-up to understand their effects on clinical events. This is especially true in patients with earlier stages of kidney disease who are unlikely to experience ESKD for many years. Surrogate study end points that occur earlier during disease progression could help. To evaluate whether eGFR decline over time may be a good surrogate end point, the authors did a meta-analysis of 14 cohorts. They found that slower eGFR decline was significantly associated with lower risk of ESKD in all populations, including those with better kidney function. The results suggest that change in the slope of eGFR decline may be a good surrogate end point for ESKD in clinical trials, particularly in longer trials with patients with rapidly progressive disease.

Background

Decline in eGFR is a biologically plausible surrogate end point for the progression of CKD in clinical trials. However, it must first be tested to ensure strong associations with clinical outcomes in diverse populations, including patients with higher eGFR.

Methods

To investigate the association between 1-, 2-, and 3-year changes in eGFR (slope) with clinical outcomes over the long term, we conducted a random effects meta-analysis of 3,758,551 participants with baseline eGFR≥60 ml/min per 1.73 m2 and 122,664 participants with eGFR<60 ml/min per 1.73 m2 from 14 cohorts followed for an average of 4.2 years.

Results

Slower eGFR decline by 0.75 ml/min per 1.73 m2 per year over 2 years was associated with lower risk of ESKD in participants with baseline eGFR≥60 ml/min per 1.73 m2 (adjusted hazard ratio, 0.70; 95% CI, 0.68 to 0.72) and eGFR<60 ml/min per 1.73 m2 (0.71; 95% CI, 0.68 to 0.74). The relationship was stronger with 3-year slope. For a rapidly progressing population with predicted 5-year risk of ESKD of 8.3%, an intervention that reduced eGFR decline by 0.75 ml/min per 1.73 m2 per year over 2 years would reduce the ESKD risk by 1.6%. For a hypothetical low-risk population with a predicted 5-year ESKD risk of 0.58%, the same intervention would reduce the risk by only 0.13%.

Conclusions

Slower decline in eGFR was associated with lower risk of subsequent ESKD, even in participants with eGFR≥60 ml/min per 1.73 m2, but those with the highest risk would be expected to benefit the most.
PERFIL EPIDEMIOLÓGICO DOS CASOS DE DENGUE NOTIFICADOS EM CERES–GOIÁS, DE 2014 A 2015
Authors: Guedes Deise Aparecida de Melo Oliveira , Rocha Benigno Alberto Moraes da
Published: July 2019

Justificativa e Objetivos:A descrição do perfil epidemiológico é uma ferramenta importante na busca por soluções eficazes no que diz

respeito, em especial, às doenças infecciosas e às alternativas de melhoria da saúde pública, sendo instrumento para o desenvolvimento

de políticas adequadas às realidades locais. O presente artigo objetiva descrever o perfil epidemiológico dos casos de dengue notificados

à Secretaria Municipal de Saúde (SMS) de Ceres-GO nos anos de 2014 e 2015. Métodos: Trata-se de um estudo observacional descritivo

de corte transversal, desenvolvido através de pesquisa e interpretação de dados do Sistema de Notificação Compulsória de dengue. As

informações coletadas foram digitadas em um banco de dados, onde os tipos de distribuição de cada variável (quantitativas e qualitativas)

foram avaliados e distribuídos em forma de tabelas, sendo realizado cálculo das taxas de incidência por 100 mil habitantes. As variáveis

estudadas incluíram dados sociodemográficos e dados laboratoriais, coletados no período de março a maio de 2017. Resultados:Durante

os anos de 2014 e 2015 foram notificados um total de 3.374 possíveis casos de dengue no município de Ceres-GO, sendo destes, 189

referentes a 2014 e 3.185 a 2015, onde a taxa de incidência por 100 mil habitantes foi de 868 e 14.537, respectivamente. Comparando-se os

registros dos respectivos anos, observa-se que houve um aumento significativo de notificações, representando um crescimento 16 vezes

maior de um ano para o outro. Conclusão:Diversos aspectos evidenciam a gravidade da dengue, já que a inadequação de diversos fatores

contribui para o maior acometimento populacional. O manejo inadequado e o gerenciamento ineficaz de casos resultam no progresso da

doença, levando à sua rápida evolução e resultando muitas vezes em óbito.

Descritores:Dengue. Perfil de saúde. Saúde pública. Notificação compulsória
SÍFILIS ADQUIRIDA: UMA REVISÃO EPIDEMIOLÓGICA DOS CASOS EM ADULTOS E IDOSOS NO MUNICÍPIO DE PORTO ALEGRE/RS
Authors: Clós Mahmud Ibrahim , Jornada Clerici Dariane , Christ Vianna Santos Roberto , Petersen Behar Paulo Renato , Luiz Terra Newton
Published: July 2019

Justificativa e Objetivos:Sabe-se que a sífilis adquirida, no cenário epidemiológico gaúcho, configura-se como doença de extrema
importância devido a sua alta prevalência e ascensão. A partir disso, o seguinte trabalho visa revisar as medidas utilizadas na assistência
dos pacientes adultos e idosos com diagnóstico de sífilis adquirida e sua epidemiologia no município de Porto Alegre/RS. Conteúdo:
Segundo dados publicados em 2016 pelo Ministério da Saúde, o crescimento da infecção por sífilis em indivíduos adultos e idosos está em
grande expansão no Brasil. Através das conquistas pelos idosos nas últimas décadas, o prolongamento da vida sexual é ponto merecedor
de destaque, além do incentivo à socialização e a falta de informação sobre saúde sexual. Conclusão:As infecções sexualmente transmis-síveis crescem nestes dois públicos e necessita-se medidas preventivas mais efetivas no âmbito da saúde pública.
Descritores: Sífilis. Doenças Transmissíveis. Saúde Pública. Doenças infecciosas
A segurança do paciente no contexto das flebites notificadas em um hospital universitário
Authors: Pereira Mariana Santana Rosário , Cunha Viviane Viana de Oliveira , Borghardt Andressa Tomazini , Lima Eliane De Fátima Almeida , Santos Tayana Fátima Ferreira , Portugal Flávia Batista
Published: July 2019

Justificativa e Objetivos:A flebite pode levar à necessidade de intervenções assistenciais de maior complexidade, como a utilização de

antibioticoterapia ou até uma intervenção cirúrgica, além de prolongar a internação do paciente e aumentar o custo e risco de infecções.

O presente estudo visa descrever as flebites notificadas em um hospital universitário e assim contribuir com possíveis ações de melhoria

na qualidade do cuidado e na segurança do paciente. Métodos:Estudo observacional de caráter retrospectivo desenvolvido em três

unidades de internação de um hospital universitário do município de Vitória, ES, Brasil. No período de junho a agosto de 2017 foram

analisados os prontuários de 76 pacientes, a partir das notificações de flebite registradas por um software eletrônico. Também foram

coletadas informações sobre as condições sociodemográficas e clínicas dos pacientes e as relacionadas aos registros de enfermagem.

Os dados foram tabulados em planilha do Microsoft Office Excel2007 e analisados pelo programa de estatísticaStatistical Package for

the Social Sciences 22(SPSS 22). Resultados: Identificou-se que 56,4% das flebites ocorreram em homens, faixa etária entre 41 e 65 anos

(42,3%) e 46,1% dos pacientes fizeram uso de antibióticos. Houve registro da conduta adotada em 59,2% dos casos, e as mais realizadas

foram compressas de gelo (44,7%) e elevação do membro (34,2%). Conclusão:O conhecimento acerca das características das flebites

notificadas propicia o entendimento e a minimização deste evento adverso, a fim de estabelecer as condutas de prevenção e diminuição

do risco e da incidência.

Descritores:Flebite. Segurança do Paciente. Cateterismo Periférico. Cuidados de Enfermagem
Núcleos Hospitalares de Vigilância Epidemiológica no Brasil: Uma Revisão Integrativa de Literatura Científica
Authors: Lima Célio Roberto da Cruz , Piva Silvana Gomes Nunes , Almeida Eliana Do Sacramento de , Almeida Vânia Menezes de , Vilas Boas Jenifen Miranda
Published: July 2019

Justificativa e Objetivos:O Brasil vem apresentando uma intensa transição epidemiológica, diante desse novo cenário, o Ministério
da Saúde decidiu criar os Núcleos Hospitalares de Epidemiologia (NHE) em hospitais de referência no Brasil. Levando em consideração
esse cenário suscitaram-se inquietações no sentido de conhecer a funcionalidade dos NHE, avaliar a partir de uma revisão de literatura
o funcionamento dos Núcleos de Vigilância Epidemiológica no Brasil. Conteúdo:Realizou-se uma revisão integrativa da bibliografia
brasileira do tipo qualitativa, realizada a partir de 10 publicações científicas em língua Portuguesa entre os anos de 2007 a 2017, indexadas
na BVS e BDTD no período de janeiro a março de 2018. Conclusão:Os Núcleos Hospitalares de Epidemiologia destacam-se como um
setor de referência para a realização da notificação compulsória e para o manejo com as situações de doenças e agravos de notificação
compulsória dentro do ambiente hospitalar. Apesar de sua importância neste contexto, verificou-se o não cumprimento das exigências e
competências estabelecidas na portaria 2.529/2004.
Descritores: Epidemiologia. Monitoramento epidemiológico. Enfermagem
EL DIEZMO COMO UNA EXPRESIÓN DE FE
Authors: B. Petersen Paul
Published: July 2019

El diezmo desempeñó un papel importante en la economía de las sociedades desde el antiguo Israel hasta los días de la Europa moderna. Si bien es cierto que es importante reafirmar la naturaleza del diezmo como señal de lealtad hacia Dios por parte de su iglesia; no obstante, la mayoría de estudiosos, especialmente pentecostales y carismáticos, prefieren enfocarse en los beneficiones materiales que uno puede obtener de Dios al diezmar. Por lo tanto, el propósito de este artículo es ir tras una motivación teológica para diezmar, bíblicamente fundamentada, con énfasis en la relación que hay entre el diezmante y Dios. Para ello, se recurrirá a las dos narrativas del Génesis, en donde se menciona al diezmo por primera vez en la Biblia. Para concluir, los hallazgos serán vistos desde una perspectiva cristológica.
LA IMPORTANCIA Y EL PAPEL DE NUESTRAS OBRAS
Authors: Moskala Jiří
Published: July 2019

Las buenas obras y los actos de bondad son extremadamente importantes, pero su valor es diferente de cómo se los considera normalmente. De hecho, la Biblia enseña claramente que somos salvos por la gracia divina mediante la fe en Jesucristo (Juan 5: 24; Rom. 3: 22-26; Efe. 2: 4-9) muy aparte de nuestras obras (Rom. 3: 21, 28; 4: 6; Gál. 2: 16). Sin embargo, si nos ubicamos en el contexto del juicio divino (Mat. 16: 27; 2 Cor. 5: 10; Heb. 9: 27), valdría la pena preguntarnos: ¿cuál es el papel de nuestras buenas obras y obediencia? Muchos cristianos socavan el valor de las buenas acciones debido al malentendido de su papel respecto al caminar cristiano con Dios.
Total RNA Protocol (extraction, quantification and Illumina library preparation) v1
Authors: Mondini Antonio , Dencker Schostag Morten , Ellegaard-Jensen Lea , Bang-Andreasen Toke , Zohaib Anwar Muhammad , Purcarea Cristina , Suhr Jacobsen Carsten
Published: July 2019

This experimental procedure was designed to isolate total the RNA aiming to obtain intact and high-quality integrity (RIN>7) for further next generation sequencing analysis. The protocol was developed to analyse the environmental microbial active community providing a clear overview of the microbial transcriptional activity in a specific time or after a different condition exposition sets, such as the investigation of thermal adaptation after heat-shock. The procedure is specifically designed to extract total-RNA from water samples although it can be used for various environmental samples as done in Schostag et al. and Bang-Andreasen et al. 2019 in soil with similar accuracy results. The total-RNA yield was >1000 ng/mL with a RIN ranging from 7 to 8.5. The final Illumina library preparation yield ranged between 15 and 31 ng/µL. This protocol isa compiled by using the Qiagen RNeasy® PowerSoil® Total RNA Kit with additional steps according the DNeasy Max®Kit (Qiagen), NEBNext® Ultra II Directional RNA Library Prep Kit for Illumina® (New England Biolabs, Inc), KAPA Library Quantification Kit for Illumina® Platforms (Kapa Biosystems), Qubit 2.0 (Thermo Fisher Scientific, Hvidovre, Denmark), Bioanalyzer® (Agilent Technologies, Inc.) sample Purification Beads (New England Biolabs) and Liquid G2 DNA/RNA Enhancer (Ampliqon) manufacturer protocols.
Protocolo de avaliação clínica audiológica para crianças com microcefalia v1
Authors: Vagner Teixeira Da Costa Klinger , Pedro Coelho Luis
Published: July 2019

Trata-se de uma ficha de anamneses direcionada para avaliação audiológica em crianças com a síndrome congênita do vírus da Zica.
Analisis Struktur dan Kemunculan Tingkat Kognitif pada Desain Kegiatan Laboratorium Materi Fotosintesis
Authors: Wahidah Nur Sopiah , Supriatno Bambang , Kusumastuti Mimin Nurjhani
Published: July 2019

In practical activities usually teachers provide guidance in the form of students’ worksheet or design of laboratory activity. Based on field studies Supriatno (2009), only 24% design laboratory that can be done with the appropriate procedures and complete results in terms of data analysis and conclusion, so it does not support the construction of knowledge. It required the analysis to determine whether design laboratory used already support the construction of knowledge. Design laboratory analysis refers to the Vee diagram and revised Bloom's taxonomy as both lead students to construct knowledge. This research is a descriptive study with purposive sampling technique. The research data captured with a rare test work results table, the table where the component diagram Vee, Vee diagrams scoring table, as well as the revised Bloom's taxonomy table. The results of the 16 samples and 5 samples design laboratory, junior high school design laboratory of photosynthetic material shows that there are still procedural mistakes and instruction unstructured. Vee diagram component analysis results show the general components that arises is the question of focus, the object/event, theories, principles, concepts and knowledge claims. Components that are generally not appear that notes/transformation. Results of the analysis showed scores of each component Vee diagram, Vee diagram on middle and high school degign laboratory generally have not yet reached the ideal score. Results of the analysis showed the emergence of the cognitive level of cognitive level generally required design laboratory in middle and high school, namely C1, C2 and C3, with dominant category procedural C3. This cognitive level is in conformity with the demands of basic competencies middle school, but not in accordance with the demands of basic competencies of high school.
Efektivitas Metode Sosiodrama Terhadap Hasil Belajar Kognitif dan Minat Belajar Siswa Biologi
Authors: Reflianto Aprianus , Bustami Yakobus , Syafruddin Didin
Published: July 2019

Cognitive learning outcomes and interest in learning are one of the supporting factors in the success of learning. This research aims to determine the results of cognitive learning and interest in learning biology through the implementation of sociodrama method to science students. The approach used in the form of a quantitative approach with the form of quasi-experimental research. The population in this research were all VIII class SMP Negeri 3 Sungai Tebelian consisting of 84 students with a total sample of 42 students. Instruments to measure cognitive learning outcomes in the form of multiple choice questions as many as 20 items, while interest in learning uses a questionnaire sheet of 15 items. Data were analyzed using descriptive statistical analysis to seem the mean value and inferential statistical analysis to seem the hypothesis test using the t-test. The results of the descriptive analysis show that the mean scores of cognitive learning outcomes and learning interest in the experimental and control classes had the same category, which was very lacking while the posttest means of cognitive learning outcomes and interest in learning in the experimental and control classes had different value categories. The experimental class has average cognitive learning outcomes and interest in learning is better than the control class. The results of the inferential statistical analysis show that the significance of cognitive learning outcomes and interest in learning is 0.00 and smaller than 0.05 so that it can be concluded that there are significant differences in cognitive learning outcomes and interest in learning through the implementation of sociodrama method.
Penggunaan Media Animasi Berbasis Macromedia Flash untuk Meningkatkan Hasil Belajar Siswa pada Konsep Materi Sistem Peredaran Darah Manusia
Authors: Situmorang Risya Pramana , Andayani Elisabeth Perti
Published: July 2019

This research aims to improve cognitive, affective and psychomotor learning outcomes through using animation based on macromedia flash. The subjects of classroom action research were 20 students, 11 male students and 9 female students from class VIII Christian Middle School 4 Salatiga. The study was conducted for 2 months in the 2017/2018 school year with 4 meetings. Measurements on cognitive learning outcomes, used instruments in the form of learning outcomes tests with 25 items, affective and psychomotor domains using questionnaire and observation sheets. Data processing and analysis used is description analysis. The percentage gain in the pre-cycle is 25% and the percentage of student learning completeness is obtained in the first cycle with a percentage of 52.9%. Furthermore cognitive learning outcomes also increased in the second cycle to 82.3%. The increase in the percentage of students 'completeness with an average of 53.4% indicates that there is a change and an increase in students' cognitive learning outcomes from the pre-cycle, cycle I and cycle IIAffective learning outcomes in the first cycle had a achievement of 55%, the acquisition of affective aspects in the first cycle still had not achieved the expected completeness, namely the standard score of 70%. However, in the second cycle the affective aspect achieved a percentage score of 78%. While the psychomotor aspects in the first cycle were 53%, increasing up to 75% in the second cycle with completeness of ≥75%.
Pencapaian Keterampilan Meneliti Abad Ke-21 Peserta Didik SMA pada Pembelajaran Ekosistem melalui Step-By-Step Model Experiment
Authors: Roito Erlien , Solihat Rini , Wulan Ana Ratna
Published: July 2019

Research skills achievement for 21st century learner in ecosystem concept through step-by-step model experiment were described in this research. Participant were 32 senior high school students which in the tenth grade. Research skills in this study are defined as the skill for finding sources of information, formulating problem, hypothesizing, analyzing data, evaluating data, and communicating in writing skill. Data was collected from student worksheets, research report, questionnaires, interviews, and field notes. Data collected were analyzed by identifying the student’s answer with RSD rubric category, then student’s score was processed into percentage in the form of table. The result showed that almost half of the students had fulfilled the criteria of maximal skill in finding the relevant source and analyzing data aspect, almost all students had fulfilled the criteria of maximal skill in formulating the problem and hypothetical aspect, most of the students had fulfilled the maximal skill criteria on evaluating data aspect, and a few of the students had fulfilled the maximal skill criteria on communicating aspect. Based on data analysis, it is found that the student achievement diverse on every aspect of research skills.
Virtual Field Trip dan Penggunaannya sebagai Fasilitator dalam Mengembangkan Keterampilan Komunikasi Abad ke-21 Siswa
Authors: Amala Hanifa Ahsanu , Amprasto Amprasto , Solihat Rini
Published: July 2019

This study using virtual field trip as a facilitator to developing 21st century skill in student. The use of virtual field trip is for developing an innovation of field trip which is visualized as internet based to provide trips on the field without leaving the classroom. This study aimed to facilitate the development of one of 4Cs component, which is communication of the 21st century skills using virtual field in ecosystem. There are 30 students (N=30) of 10th grade in science class at senior high school 20 Bandung became subject. The instrument using eight question for assessed written communication skill, observation rubric for assessed verbal communication skill, and response questionnaire. Through the result, we found thatstudent’s written communication skill has been increasing and included as a middle category of N-gain. The observation showed that students having a good profile on verbal communication skills. This result has been supported by the questionnaire which is all students say agree (57%) and very agree (43%) with the statement that this method help to make learning ecosystem became more interesting and perceivable.
Pengaruh Kedisiplinan Belajar Terhadap Hasil Belajar Mahasiswa dalam Mata Kuliah Konsep Dasar IPS
Authors: Kristin Firosalia , Kencana Sari Fransiska
Published: July 2019

Penelitian ini bertujuan mengetahui pengaruh kedisiplinan belajar terhadap hasil belajar mahasiswa dalam mata kuliah konsep dasar IPS. Jenis penelitian ini adalah penelitian asosiatif dengan desain expost facto. Subjek penelitian adalah 60 mahasiswa PGSD UKSW angkatan 2017. Pengumpulan data dilakukan melalui angket dan tes. Anaisis data dilakukan dengan teknik uji regresi linier yang mencakup uji  t dan pengukuran koefisien determinasi. Hasil penelitian menunjukkan 1) Nilai t hitung 2,904 > nilai t tabel 1,999, maknanya terdapat pengaruh kedisiplinan belajar teradap hasil belajar Konsep Dasar IPS Mahasiswa; 2) Nilai R Square sebesar 0,127, dengan arti bahwa pengaruh variabel kedisiplinan belajar terhadap variabel hasil belajar Konsep Dasar IPS Mahasiswa adalah 12,7%. Simpulannya melalui uji t menunjukkan adanya pengaruh kedisiplinan tergadap hasi belajar mahasiswa dalam mata kuliah Konsep Dasar IPS dengan pengaruh sebesar 12,7% yang ditunjukkan melaui hasil pengukuran koefisien determinasi.