bluuebunny/crossref_metadata_2025 huggingface dataset:
Development and Characterization of Thermoreversible In-situ Gel Containing Curcumin Nanoparticles for Nasal Delivery: Design, Ex-Vivo Study
Authors: Mamatha G. T. , Jat Rakesh Kumar
Published: February 2024

The present study aimed to develop and evaluate thermoreversible in situ nasal gel containing Curcumin nanoparticles. Curcumin nanoparticles were prepared by the ionic gelation method. These formulations were evaluated for entrapment efficiency, particle size, zeta potential, and In vitro drug release. Particle size and zeta potential of F1 formulation were found to be 299 nm, 0.1 mV, and entrapment efficiency was found to be87.2%. From the formulations, F1 shows maximum amount of drug released in a sustained manner for a prolonged period time. Hence F1formulation was selected as optimized and further used for thermoreversible in situ nasal gel by using 2×2 factorial designs. The thermoreversible nasal gel was evaluated for the gelation temperature (33˚C), viscosity (10550cps) and spreadability (17.29±0.3 gm*cm/sec). Further, the prepared gel (F1G3) was evaluated for ex vivo permeation study for12 hours and it shows maximum amount of drug release in a controlled manner. The % CDR of thermoreversible in situ gel formulation F1G3 was found to be 86.27% which follow the Higuchi model. The 'n' value of the formulation was found to be more than 0.5. This indicate that the release approximates the non-fickain diffusion mechanism.

Keywords: Curcumin nanoparticles, Carbopol 934, PF127, Thermoreversible in situ gel, Cold method, Nasal delivery.
Stability Study of a Formulation Based on Pineapple Juice and Hibiscus sabdariffa Concentrated Extract for the Preparation of Food Supplements
Authors: N’GUESSAN-GNAMAN Kakwokpo Clémence , TUO-KOUASSI Nakognon Awa , AKA-ANY-GRAH Sandrine , ANIN Apo Laurette , DALLY Ismael
Published: February 2024

The aim of this study was to evaluate the influence of additives on the stability of a beverage based on pineapple juice and Hibiscus sabdariffa concentrated extract at room temperature. This beverage was intended to be used to formulate food supplements. Acidifier (citric acid), antioxidant (ascorbic acid) and antimicrobial (sodium benzoate and potassium sorbate) were added alone or in combination. Organoleptic, physicochemical (pH, titratable acidity and Brix degree) and microbiological characteristics were observed over a 21-day period. Beverages containing potassium sorbate (1 g/L) and sodium benzoate (0.5 g/L) were more stable over 21 days.
Keywords: dietary supplements, storage, bissap, extract
University-led dialogues with society: balancing informing and listening?
Authors: de Roo Nina , Metze Tamara , Leeuwis Cees
Published: February 2024

In response to a growing understanding that scientific knowledge is not always trusted at face value, many universities organise dialogues to `open up' to society. In four exploratory case studies at the Dutch Wageningen University & Research, we looked into the adherence to dialogue principles and the roles that researchers performed while engaging in dialogues. We found that researchers face three challenges when interacting with societal stakeholders in dialogues: (1) moving from knowledge provider to “letting in” and listening to different perspectives (2) balancing attention toward knowledge with attention toward values and emotions (3) navigating different aspired and perceived roles of researchers in dialogue (e.g. Pure Scientist versus Issue Advocate).
El papel preventivo de la divulgación de la ciencia para poblaciones vulnerables ante amenazas ambientales
Authors: Sánchez-Mora María del Carmen , Macías-Nestor Alba Patricia
Published: February 2024

La población mundial envejece coincidentemente con una situación ambiental crítica debida al cambio climático, que amenaza a poblaciones vulnerables, entre ellas a muchos adultos mayores. Se presenta un ejercicio de divulgación de la ciencia sobre cambio climático que parte de detectar los conocimientos y actitudes de esta población sobre el tema, a partir del cual se propone un taller para promover el autocuidado frente a riesgos ambientales. El taller mostró la posibilidad de reducir el desconocimiento sobre el tema y promover el autocuidado y la responsabilidad social con lo que se alimentará un guión museográfico adaptable a diferentes contextos y necesidades.
Clinical cases of “MR-negative” myelopathy amid SARS-CoV-2 infection
Authors: Kushnir Yana B. , Bezvodinskikh Alexander I. , Vladykina Anastasiya V. , Gotovchikov Andrey A. , Totolyan Natalya A.
Published: February 2024

INTRODUCTION. Neurological complications are often observed in patients with a new coronavirus infection. Cerebrovascular diseases prevail among them. There is damage to the peripheral nervous system and spinal cord of various kind, including inflammatory and vascular myelopathy. The incidence of myelopathy syndrome among all neurological complications of the new coronavirus infection reaches 3%.
OBJECTIVE. To characterize clinical and instrumental features of the rare case – “МR-negative” myelopathy amid SARS-CoV-2 infection.
MATERIALS AND METHODS. The article describes a clinical case of myelopathy, associated with COVID-19 without structural changes in the spinal cord on MR-imaging using standard pulse sequences, however, visualized via spinal tractography.
CONCLUSION. COVID-19 associated myelopathy is one of the characteristic complications amid the new coronavirus infection. To verify “MR-negative” damage to the central nervous system in COVID-19, advanced protocols of MRI studies might be used, including the promising method – МR-tractography.
Um brasileiro sonha com George Washington e seu “discurso de despedida”
Authors: Carvalho de Mesquita José Marcos
Published: February 2024

George Washington serviu como Comandante em Chefe do Exército Continental na Guerra Revolucionária (1775-83). Após um curto período de aposentadoria, ele se tornou o principal impulsionador das etapas que levaram à Convenção Constitucional na Filadélfia em 1787. Quando a nova Constituição foi ratificada, o Colégio Eleitoral elegeu Washington, por unanimidade, como o primeiro presidente dos EUA.
Probabilistic and Harmonic Assessment of Power Quality Parameters from Distributed Energy Resources in a Distribution Network
Authors: Caballero-Peña Juan , Osma-Pinto German
Published: February 2024

Distributed energy resources (DERs) are leading actors in energy transition worldwide. Despite the environmental benefits, DERs are intermittent (consumption/generation power changes according to the input variables), and the use of power electronic devices affects the power quality in distribution networks. Typically, models and simulations (deterministic or probabilistic) are proposed to estimate such impacts. However, previous studies have analyzed the main effects caused by one or two DERs during a day. These studies had a reduced level of detail in the applied methodology in modeling and impact evaluation, or they did not consider that the harmonic distortion level depends on input variables. The aim of this article was to develop a probabilistic harmonic simulation approach to characterize the hourly effect of photovoltaic systems (PVS), battery energy storage systems, and electric vehicle charging stations in a 34-node IEEE test feeder. The individual and collective effect estimation of the DERs consists of the hourly quantification of the effective voltage value, voltage unbalance, power factor, and harmonic distortion, with data obtained using Python and PowerFactory co-simulation for 23 operation scenarios. These impacts were assessed through indicators proposed in the literature and hypothesis tests (inferential statistics). Each DER generally operates at a specific time, making it easy to identify the individual effects of network parameters. The PVS increased the effective voltage value and total harmonic distortion. However, electric vehicles and batteries increase the voltage unbalance and power factor due to the two-phase connection in some network nodes.
Pursuing Scholarship: Creating Effective Conference Submissions
Authors: Culmer Nathan , Drowos Joanna , DeMasi Monica , Kenyon Tina , Figueroa Edgar , Pfeifle Andrea , Malaty John , Schneider F. David , Hartmark-Hill Jennifer
Published: February 2024

Medical educators are expected to disseminate peer-reviewed scholarly work for academic promotion and tenure. However, developing submissions for presentations at national meetings can be confusing and sometimes overwhelming. Awareness and use of some best practices can demystify the process and maximize opportunities for acceptance for a variety of potential submission categories. This article outlines logistical steps and best practices for each stage of the conference submission process that faculty should consider when preparing submissions. These include topic choice, team composition, consideration of different submission types, and strategies for effectively engaging participants.
Evaluating Barriers to Opioid Use Disorder Treatment From Patients’ Perspectives
Authors: Nguyen* Cecilia M.T. , Kubiak* Grace , Dixit* Neil , Young Staci A. , Hayes John R.
Published: February 2024

Introduction: Utilizing medications to treat opioid use disorder (MOUD) is both highly effective and unfortunately underutilized in the US health care system. Stigma surrounding substance use disorders, insufficient provider knowledge about substance use disorders and MOUD, and historical lack of physicians with X-waivers to prescribe buprenorphine contribute to this underutilization. Our study aimed to elucidate barriers to accessing MOUD in Milwaukee, Wisconsin.
Methods: We conducted semistructured interviews with patients receiving MOUD at a family medicine residency program in Milwaukee, Wisconsin. Interviews were audio-recorded, transcribed verbatim, and analyzed using the qualitative analysis Framework Method. Researchers in our team reviewed transcripts, coding for specific topics of discussion. Coded transcript data were then sorted into a matrix to identify common themes.
Results: Interviews with 30 participants showed that motivations to seek treatment appeared self-driven and/or for loved ones. Eighteen patients noted concerns with treatment including treatment denial and efficacy of treatment. Housing instability, experiences with incarceration, insurance, and transportation were common structural barriers to treatment.
Conclusions: Primary drivers to seek treatment were patients themselves and/or loved ones. Barriers to care include lack of effective transportation, previous experience with the carceral system, and relative scarcity of clinicians offering MOUD. Future studies may further explore effects of structural inadequacies and biases on MOUD access and quality.
La naturaleza jurídica del juicio de amparo indirecto
Authors: Tapia Chávez Christian Miguel
Published: February 2024

The amparo trial is a means of constitutional control and conventionality in the Mexican legal system, in the aspect of indirect amparo trial, it is the means par excellence for the defense of human rights and its guarantees against acts of authority or omissions that it carries out against of the governed. By excellence, it is the means by which a governed that sees their human rights violated or failing that, a legal guarantee, can actuate said means to request that the constitutionality or unconstitutionality of the act of authority be studied. The amparo trial has its origin in 1841, idea of ​​the politician and jurist Manuel Crescencio Garcia Rejon y Alcala, later by means of his “private vote” he laid the foundations for the amparo trial in Mexico, the jurist Mariano Otero.
Contabilidad electrónica y su aplicación en el crecimiento empresarial
Authors: Morales Diaz Marian Arleth , Ancona Alcocer María del Carmen , Murillo González Gilberto
Published: February 2024

Accounting has been a profession that has evolved and has taken great importance within various economic sectors where one of them is the business sector, this is due to the control and registration of the resources that enter and leave this type of entities to have a stable financial life as well as knowing how their finances are for an adequate decision making. Nowadays with the arrival of new technologies the accounting area has brought with it great changes among them the application of electronic accounting with which it facilitates the realization of a great diversity of accounting tasks making its processes more efficient as well as reducing the time in which each of them is carried out. The objective of this research is to describe through a descriptive methodology how electronic accounting has had an important impact on the growth of companies, where it could be concluded that electronic accounting has been of great help for the growth of companies.
Perception of the benefits of financial inclusion and healthy finances in students of the Bachelor's Degree in Public Accounting
Authors: Zenteno de la Rosa Andrés Antonio , Martínez Prats Germán , Silva Hernández Francisca , Guzmán Fernández Candelaria
Published: February 2024

This article investigates the perception of students of the Bachelor of Public Accounting about the benefits of financial inclusion and healthy finance. Using a qualitative approach, participants' opinions and attitudes towards these key concepts were explored in the context of their academic background and future career. The results revealed a variety of perspectives around financial inclusion, from its role in equal opportunities to questions about its effectiveness in addressing systemic challenges. As for healthy finances, a solid understanding of its importance for economic stability was evidenced, although areas of ignorance, such as complex investments, were also identified. Training in Public Accounting influenced a deeper understanding of technical and regulatory aspects.
Utilización de residuos de pescados como alternativa para el mejoramiento de la alimentación humana y disminución del desperdicio de alimentos.
Authors: Barrera Hernández Martha , Jaimes Ariza Lady Viviana , Serrano Osma Juan Camilo
Published: February 2024

En el 2022, según datos del sistema estadístico pesquero colombiano la pesca y la acuicultura alcanzaron una producción de 300.163 toneladas, por otra parte, en el 2022 Bogotá comercializo 3171 toneladas de pescado (Rangel et al., 2022). Por lo expuesto la industria pesquera representa grandes cantidades de residuos anualmente, lo que resulta en pérdidas económicas e impactos negativos en el medio ambiente.
 
Estudios realizados por estudiantes del semillero de investigación Agroalimentaria SIA de la UNAD, determinaron que en un servicio hotelero se puede llegar a desperdiciar entre 43 y 53% en variedades de pescados como corvina, mero variedad cherna y Berrugate, robalo nacional del pacífico, bagre variedad Cajaro considerando cabeza, aleta, espinazo piel y cola. Otros estudios han demostrado que dichos residuos se pueden usar de manera eficiente para múltiples propósitos: mejorar las propiedades funcionales de los alimentos, proporcionar nutrientes esenciales, obtención de gelatina, uso cosmético y en la industria de la bisutería, permitiendo el procesamiento integral de este producto. La investigación de SIA, caracterizo estos residuos, los sometió a un tratamiento de deshidratación bajo condiciones de proceso contraladas y mediante análisis fisicoquímicos incluyendo cromatografía de gases de residuos y deshidratado, se determinó que estos poseen  características nutricionales incluso mejores que el filete que consumimos con presencia de ácidos grasos esenciales y sus eicosanoides, resultando ser una alternativa que disminuye el desperdicio de alimentos y aporta nutrientes esenciales que solo pueden ser sintetizados a través de la alimentación. Los ácidos grasos esenciales y sus eicosanoides se relacionan con funciones neurológicas y antiinflamatorias, asimismo en la prevención de múltiples enfermedades
Generación y reducción de pérdidas y desperdicios de alimentos. Aprendizajes desde la Maestría en Soberanía y Seguridad Alimentaria y Nutricional de la Universidad Nacional de Colombia
Authors: Jara Nercasseau Macarena , Olano Delgado Sandra Patricia , Parrado Barbosa Álvaro
Published: February 2024

Las pérdidas y desperdicios de alimentos (PDA) han venido ganando visibilidad en la agenda académica y política latinoamericana como un problema de gran magnitud, con graves repercusiones ambientales, éticas, sociales y económicas, pero a su vez se están generando políticas, estrategias y acciones para contribuir a su reducción e incidencia.
La Maestría en Soberanía y Seguridad Alimentaria y Nutricional de la Universidad Nacional de Colombia no ha sido ajena a esta situación y desde su creación en el año 2015 ha venido estudiando el tema desde las investigaciones realizadas por estudiantes y profesores de diversas disciplinas, analizando sus causas, repercusiones y las alternativas para la reducción de PDA en diferentes espacios, incluyendo las pérdidas generadas en los procesos de producción y distribución de papa criolla en Nariño y Cundinamarca y de hortalizas en la Zona Central de Chile, así como los desperdicios que se dan en la mayor institución educativa escolar pública de Bogotá y en dos instituciones educativas del municipio capital de Arauca.
Los aprendizajes obtenidos a través de los procesos de investigación participativa recogen las vivencias y percepciones de quienes se relacionan con las PDA desde la producción, la distribución y consumo de alimentos, y aportan nuevas miradas y estrategias para contribuir a lograr su reducción y manejo de manera sostenible.
Implementación de Biodigestores para el aprovechamiento de residuos en pequeñas unidades productivas agropecuarias
Authors: Valencia Achuri Paola Andrea , Abril Herrera Diego
Published: February 2024

In isolated areas that are difficult to access for energy interconnection, it is necessary the production of alternative energies highlighting biomethane which is generated from the anaerobic digestion of organic matter. The objective of this document is to present some results of an intervention experience in 6 agricultural production units located in villages near the city of Fusagasugá, in which biodigesters were developed to improve the conditions of energy production under environmental sustainability parameters.
 
For the selection of the 6 productive units, there were analyzed the conditions of 21 productive units from 13 villages near the city of Fusagasugá, referenced by the Sumapáz livestock committee. The analysis was based on the availability of waste in accordance with the requirements for the proper functioning of the biodigesters, and the willingness of the owners for the implementation of biodigesters as energy complementarity in small agricultural units.
 
Among the most relevant results, it was found that there are drawbacks of adopting this type of alternative energy in rural productive units with the decision of only 6 properties from the 21 productive units consulted representing 28,5%, situation that shows some challenges related to strategies to connect isolated rural populations with the implementation of biodigesters as complementary energy in small agricultural units.
Is ESG disclosure creating value propositions for the firms? An SLR and meta-analysis of how ESG affects the financials of a firm
Authors: Kalyani Sushil , Mondal Rima
Published: February 2024

This systematic literature review (SLR) delves into the evolving landscape of environmental, social, and governance (ESG) disclosures and their consequential effects on the financial performance of firms. As sustainability considerations increasingly influence investment decisions, corporations are compelled to integrate ESG factors into their reporting practices. The primary objective of this research is to comprehensively analyze existing literature, elucidating the patterns, trends, and key insights surrounding ESG disclosures and their repercussions on financial outcomes. The study employs a systematic approach to identify, evaluate, and synthesize pertinent research articles, academic papers, and industry reports. It explores the multifaceted dimensions of ESG disclosures, encompassing environmental stewardship, social responsibility, and governance practices. The analysis spans diverse sectors, examining how ESG reporting has become a crucial component of corporate transparency and stakeholder engagement. The review aims to distill overarching themes from the literature, providing a nuanced understanding of the relationship between ESG disclosures and financials. Preliminary findings suggest that ESG disclosures are positively associated with enhanced financial performance, fostering long-term value creation for firms. However, variations exist in the significance of these relationships across industries and regions. Furthermore, the review highlights the emergence of standardized frameworks and reporting guidelines as essential catalysts for advancing ESG disclosure practices. This research contributes to the ongoing dialogue on sustainable finance by consolidating diverse perspectives and methodologies found in the literature. The synthesis of existing knowledge seeks to inform future research directions, guide corporate practices, and assist policymakers in shaping frameworks that promote responsible and transparent business conduct. In total, 650 articles were reviewed to explore the effect the ESG disclosure has on the financial performance of the firms.
Risk of Anaphylaxis Among New Users of GLP-1 Receptor Agonists: A Cohort Study
Authors: Anthony Mary S. , Aroda Vanita R. , E. Parlett Lauren , Djebarri Leila , Berreghis Sofia , Calingaert Brian , C. Beachler Daniel , L. Crowe Christopher , B. Johannes Catherine , Juhaeri Juhaeri , Lanes Stephan , Pan Chunshen , J. Rothman Kenneth , W. Saltus Catherine , E. Walsh Kathleen
Published: February 2024

Objective: To assess risk of anaphylaxis among patients with type 2 diabetes mellitus initiating a glucagon-like peptide-1 receptor agonist (GLP-1 RA), with a focus on those initiating lixisenatide.

Research design and methods: A cohort study was conducted in 3 large United States claims databases (2017-2021). Adult (aged ≥18 years) new users of a GLP-1 RA with type 2 diabetes mellitus and ≥6 months enrollment in the database before GLP-1 RA initiation (start of follow-up) were included. GLP-1 RAs evaluated were lixisenatide or insulin glargine/lixisenatide fixed-ratio combination (FRC), exenatide, liraglutide or insulin degludec/liraglutide FRC, dulaglutide, and semaglutide (injectable and oral). The first anaphylaxis event during follow-up was identified using a validated algorithm. Incidence rates (IRs) and 95% CIs were calculated within each medication cohort. The unadjusted IR ratio (IRR) comparing anaphylaxis rates in the lixisenatide cohort to all other GLP-1 RAs combined was analyzed post hoc.

Results: There were 696,089 new users with 456,612 person-years of exposure to GLP-1 RAs. Baseline demographics, comorbidities, and use of other prescription medications in the 6 months before index date were similar across medication cohorts. IRs (95% CIs) per 10,000 person-years were 1.0 (0.0-5.6) for lixisenatide, 6.0 (3.6-9.4) for exenatide, 5.1 (3.7-7.0) for liraglutide, 3.9 (3.1-4.8) for dulaglutide, and 3.6 (2.6-4.9) for semaglutide. The IRR (95% CI) for anaphylaxis rate for the lixisenatide cohort compared with the pooled other GLP-1 RA cohort was 0.24 (0.01-1.35).

Conclusions: Anaphylaxis is rare with GLP-1 RAs. Lixisenatide is unlikely to confer higher risk of anaphylaxis than other GLP-1 RAs.
The Development of E-Module of Hydrocarbon Material Using Lectora Inspire
Authors: Miranti Maya , Muharini Rini , Lestari Ira , Erlina  , Sahputra Rachmat
Published: February 2024

Hydrocarbon material is one of the materials in chemistry which is a problem for chemisty education students. In order to develop learning media that makes it easier for students to understand hydrocarbon, research to the development of e-modules is carried out. The goal of this research is to create an e-module of hydrocarbon material that is useful and receives positive feedback. ADDIE model consisted of analysis, design, and development was used as research and development model in this study. In total 12 students from the Chemistry Education Study Program FKIP Untan, and 32 students from the main test served as respondents. Measurement and indirect communication techniques are employed in the investigation. Feasibility evaluation sheets and response questionnaires are the instruments utilized for data collection. The results show that the e-module is highly viable, with a percentage of material feasibility 88%, linguistic feasibility 91%, technical feasibility 92%, and 95% graphic viability. In the initial experiment, the proportion of student questionnaire responses was calculated at 83%, and in the main test, it was calculated at 84%, which was deemed to be very good. E-module of hydrocarbon material using Lectora Inspire was pronouneed to be extremely feasible and received a very good reaction based on the research findings, that it can be used as a learning resource in learning hydrocarbon material to improve students’ understanding.
Biblical Courtship and Spiritual Entities: An Exegesis of Philippians 2:3-4
Authors: Adeoye Moses Adeleke
Published: February 2024

The relationship between biblical courtship and spiritual entities is multifaceted and interconnected. In Christian courtship, this means being mindful of the other person's needs and desires and working together to build a relationship that is centered on mutual respect and support. The focus of this paper is to analyze Philippians 2:3-4 and examine the relationship between biblical courtship and spiritual entities. This research uses a descriptive method. Data collection in this research as primary data uses document analysis and also supported by secondary data from previous research. Data analysis process is through classifications, interpretation, compare the data, and analyze the context and meaning. The result found exegesis of Philippians 2:3-4 provides valuable guidance for Christian courtship by embracing humility, selflessness and spiritual practices to cultivate the qualities necessary for a healthy and loving relationship with another person. Biblical courtship would prioritize empathy, compassion, communication, practicing forgiveness, seeking to understand and meet the needs of one's partner. Spiritual entities provide guidance and tools for individuals to cultivate a deeper relationship with God and their partners by cultivating a deep and abiding relationship with God and prioritizing spiritual disciplines such as prayer, Bible study and worship. By incorporating these practices and principles into courtship, couples can build a strong foundation for a lifelong, Christ-centered relationship. In conclusion, biblical courtship should be grounded in a biblical worldview with individuals seeking to align their values and priorities with those of Christ.
Implikasi Seni dalam Bermain Alat Musik Drum pada Anak Usia Dini
Authors: Rahmi Aulia , Maemonah M
Published: February 2024

In the artistic aspect, every child is a unique individual. Musical development in children involves an environment that encourages exploration, expression, and appreciation of art in the context of play. It involves the ability to explore and express oneself by using imagination in movement. The purpose of this study to explain the activities of playing musical instruments in early childhood. This research method is qualitative research with a case study approach as an analytical tool. Data was collected through direct observation, documentation, and literature review. This research was conducted at RA Ibnu Sina Palembang, with the subjects being class B students at that institution. Based on the results of the research, researchers found 3 indicators, namely children using drum musical instruments where the child was given a drum instrument first, correcting the position of the drum according to the child's comfort, the way the child expressed musical instruments by hitting the drum with a very happy face, and the teacher revealed the concept of the instrument. music by providing teaching in stages, one beat after another, so that every child can understand it.
Pengembangan Literacy Digital Anak Usia Dini Melalui Pembelajaran Computer Kids
Authors: Shofa Mila Faila
Published: February 2024

The purpose of this study is to determine the developing digital literacy in early childhood through Computer Kids learning. This research uses descriptive qualitative methods. Data collection techniques through interviews, documentation, and observation. Data validity techniques use source triangulation and triangulation methods. Data analysis uses interactive data analysis, presentation of data, data reduction, and drawing conclusions. The results showed that Computer Kids learning at PAUD Inclusion Saymara was carried out once a week in the multimedia room. Before carrying out learning, educators make plans related to the material to be delivered. The learning materials for Computer kids include getting to know the hardware, the parts of the computer, turning the computer on and off. In addition, software that is suitable for early childhood is also introduced such as interactive games, Microsoft Paint, Microsoft Word where children can recognize shapes, letters, and numbers. Through this Computer Kids learning, children have the knowledge and skills to utilize digital media wisely, intelligently, meticulously, and precisely according to their age development.
O jogo africano mancala no desenvolvimento de habilidades matemáticas de estudantes dos anos finais do Ensino Fundamental
Authors: Lima Paulo Vinícius Pereira de , Sousa Luciane Alves Rodrigues de , Santos Hélio Rodrigues dos , Moreira Geraldo Eustáquio
Published: February 2024

Este artigo tem como objetivo geral investigar as concepções dos estudantes a respeito dos possíveis impactos do jogo Mancala no processo de ensino e aprendizagem nos anos finais do Ensino Fundamental. Como objetivos secundários, nos propomos a identificar as concepções dos estudantes frente à utilização do jogo Mancala, refletir sobre os possíveis benefícios para a aprendizagem em Matemática e por fim analisar se as práticas com o jogo Mancala favoreceram um melhor desempenho no campo de conhecimento da Matemática. O referido artigo buscou responder à seguinte inquietação: A utilização do jogo Mancala em sala de aula contribui para uma ruptura do ensino tradicionalista no processo de ensino e aprendizagem em Matemática dos estudantes dos anos finais do Ensino Fundamental?  A pesquisa feita foi de abordagem qualitativa do tipo exploratória; como método foi utilizada a pesquisa participante e os instrumentos de coleta de dados utilizados foram o questionário e a técnica de análise de dados. Utilizou-se, ainda, a análise de conteúdo. Os resultados oriundos das análises dos questionários revelaram que o jogo Mancala assume fator diferencial, pois, além de trabalhar a Matemática, é possível abordar a cultura e as histórias africanas; contribui para o cumprimento obrigatório da Lei 10.639/03 com importantes mudanças no processo de ensino e aprendizagem dos estudantes, desmistificando o olhar que eles atribuem à disciplina de Matemática e rompem com preconceitos de que é uma área de conhecimento para poucos. Possibilitou, ainda, uma motivação a mais no que diz respeito às suas aprendizagens atinentes à disciplina de Matemática.
Current state and problems of additional education development
Authors: Яновская Галина Александровна
Published: February 2024

В данной статье показано усиление роли дополнительного образования, его востребованности среди потребителей и заказчиков, проведен краткий анализ рынка образования в России и мире с учетом развития рынка образовательных технологий. Проанализированы сегменты частного и государственного образования, их характеристики, преимущества и недостатки. Исследованы современное состояние, нормативные изменения в области дополнительного образования, системы подготовки педагогов дополнительного образования к реализации трудовых функций с учетом внедрения профессиональных стандартов. Проведен анализ российской реферативной базы публикаций в области подготовки педагогов дополнительного образования, развития их компетентности, оценки качества и т. д. По итогам проведенной работы выделен ряд проблем, касающихся подготовки педагогов дополнительного образования к профессиональной реализации трудовых функций на высоком уровне, которые не нашли отражения в трудах современных ученых.

This article examines the increasing role of supplementary education, its demand among consumers and customers. It contains a brief analysis of the education market in Russia and the world, taking into account the development of the educational technology market. The segments of private and public education, their characteristics, advantages and disadvantages are analyzed. The current state, regulatory changes in the field of supplementary education, the system of preparation of teachers of supplementary education for the implementation of labor functions, were studied with regard to the implementation of professional standards. The analysis of Russian and foreign literature on supplementary education teachers’ training, competence development, quality assessment, etc. was carried out. The analysis highlights a number of problems concerning the preparation of supplementary education specialists for professional implementation of labor functions at a high level, and these problems have not been addressed by modern scientists. Among the identified problems are the lack of prospects for the emergence of a sufficient number of qualified additional education specialists in the regions of Russia, low qualification of teachers and management of educational organizations, low technological literacy of teachers, the gap between the public and private segments of the education market, the obsolescence of traditional teaching formats, low motivation for change and development, burnout among employees of educational organizations, etc.
Morphological changes in the abdominal organs after left gastric artery embolization in an experiment
Authors: Prodan A.M. , Golovata T.K.
Published: February 2024

Objective – to experimentally evaluate the morphological changes of internal organs (liver, spleen, duodenum, pancreas) after embolization of gastric arteries.Material and methods. To conduct the experiment, 10 Vietnamese pigs aged 4-5 months, female, were selected and fed a high-fat diet for 2 months to simulate obesity. Aorta contrast and celiacography with "Vazipak" solution (5-10 ml per injection) were performed on animals under general anesthesia. Superselective bariatric embolization of the left gastric artery was performed with a 3F microcatheter. After 3 weeks, a morphological (hematoxylin-eosin staining) examination of such organs as liver, duodenum, spleen, pancreas was performed. Photofixation of the histopreparations of the relevant organs was carried out using a trinocular microscope of laboratory class Nikon Eclipse Ci-E with 10x, 20x and 40x plan achromat objectives.Results. In general, no macroscopic signs of ischemia of adjacent organs were noted against the background of the performed selective embolization of the left gastric artery. Blood filling of the liver was uneven, the perisinusoidal spaces were expanded, which indicated its edema. In the duodenum, reactive disturbances of microcirculation were manifested by expansion and congestion of venous vessels and blood stasis. Microscopic changes in the spleen were characterized by congestion of the sinusoids, while the vessels of the pancreas were unevenly filled with blood, and at the same time, venous congestion prevailed.Conclusion. Microcirculation disorders, dystrophic changes, and signs of a shock reaction, which can be considered transient, occur in the examined organs after embolization of the gastric arteries. These data indicate the safety of performing selective embolization of gastric arteries and the absence of signs of critical redistribution of blood flow or ischemia "robbing".
Distance education for the profit of newly recruited teachers: reinforcing inclusive classroom strategies through UFMC Algerian training
Authors: Belaid Louiza
Published: February 2024

Although the educational sector has witnessed an exceptional advancement in computer technologies, their smart use was fairly limited in the EFL context. Hence, the unexpected pandemic encouraged teachers to adopt a non-traditional approach to meet the students’ learning needs. Blended learning was readily arrogated to deliver the courses on-line and decrease the social distance at university. In parallel, UFMC Algerian training was scheduled by Constantine University –Algeria- for the benefits of newly recruited teachers to improve their on-line teaching. Thus, the new learned skills were momentarily applied to reinforce a blended approach to learning with Master Students at Ibn Khaldoun University, Algeria. Upon students’ consensus, on-line interaction was not accredited before the pandemic that is why a clash arose between distance education and face-to-face interaction. In this prospect, it is recommended to train teachers and learners in the usability of MOOCs to elevate learners’ inclusion in the classroom and raise their awareness vis-à-vis self-blend and flex models.
A nemzetközi kereskedelem hatékonyságának növelése
Authors: Aminizadeh Laya
Published: February 2024

Ein Akkreditiv ist ein wichtiges Dokument, das im internationalen Handel häufig verwendet wird, vor allem zu Zahlungszwecken, und den beteiligten Parteien daher Rechte und Pflichten auferlegt. Die Zahlung und Erfüllung von Verpflichtungen gehören zu den wichtigsten Aspekten eines jeden Vertrags. Unter den Zahlungsarten im internationalen Zahlungsverkehr ist das Akkreditiv aufgrund seiner Besonderheiten das zuverlässigste und bedeutendste Zahlungsmittel. Durch die Einbindung von Banken gewährleistet ein Akkreditiv sowohl für den Verkäufer als auch für den Käufer eine sichere Interessensicherung und lindert so deren Bedenken. Angesichts der Fortschritte im internationalen Handel wird es jedoch unerlässlich, die Auswirkungen neuer Technologien auf Zahlungsmethoden in internationalen Geschäftsbeziehungen zu berücksichtigen. Dieser Kommentar zielt darauf ab, aktuelle Forschungsergebnisse zur Nutzung von Blockchain-basierten Akkreditiven zu untersuchen und einen umfassenden Überblick über die regulatorischen Rahmenbedingungen in diesem Bereich zu bieten. Nach einer detaillierten Beschreibung der Blockchain-Struktur für Akkreditive und der Untersuchung der Anwendungsfälle von Smart LCs legt die Untersuchung nahe, dass bestehende Rechtsrahmen wie UCP, eUCP, ISP98 und UN LC-Übereinkommen als Grundlage für die Verwaltung Blockchain-basierter LCs mit notwendigen Änderungen dienen können. Durch die Integration der Blockchain-Technologie und die Nutzung dieser Frameworks kann die Handelsfinanzierung von mehr Effizienz, Transparenz und Sicherheit profitieren.
Caminando sobre la muerte: lápidas funerarias usadas como pisos
Authors: Schávelzon Daniel
Published: February 2024

Un hallazgo casual permitió observar que los pisos de baldosas de mármol provenientes de Carrara que forman los caminos que rodean la que fuera la Municipalidad del pueblo de Belgrano, construida en 1875, están hechos con lápidas funerarias. Hipotetizamos que dichas piezas provinieron de cementerios del pueblo y fechamos su colocación en 1908, interpretando el acto (que en otro momento hubiera sido sacrilegio) como el cierre de la larga polémica en la separación entre Estado e Iglesia. Cabe recordar que esa construcción fue sede del Gobierno Nacional en 1880, museo desde 1938 y que allí mismo hubo fuertes polémicos sobre la laicización definitiva de la muerte. La destrucción del piso sin control alguno y el hecho que diferencias políticas impidieron el trabajo arqueológico sirven para entender los problemas que aquejan a la arqueología, los museos y al patrimonio nacional, en función de la creciente politización de las decisiones y al manejo discrecional de recursos.
Analysis of NLR, PLR, and Carcinoembryonic Antigen in Colorectal Cancer Patients
Authors: Parabang Budi , Esa Tenri , Bahrun Uleng
Published: February 2024

Colorectal cancer (CRC) is the second leading cause of cancer death worldwide. The development and prognosis of CRC are affected by the tumor's appearance and the host's inflammatory response. A combination of several parameters, including the Neutrophil-Lymphocyte Ratio (NLR) and Platelet-Lymphocyte Ratio (PLR), has been used as a cancer prognostic marker. Research needs to be performed to analyze its role in CRC. This study aimed to determine the differences in the NLR, PLR, and CEA values with the severity and site of CRC. Medical record data were collected from 246 CRC patients from January 2021 to June 2022 at Dr. Wahidin Sudirohusodo Hospital were used and grouped by severity (metastatic and non-metastatic) and site (left colon, right colon, rectum). This study collected the data on NLR, PLR, and CEA levels. The Mann-Whitney, Spearman Rho, and Kruskal-Wallis tests were used for statistical analysis by the research objectives (significant if p<0.05). There were differences in median PLR (194.47 vs. 201.18; p=0.045) and CEA (3.3 ng/mL vs. 11.95 ng/mL; p<0.001) between the metastatic and non-metastatic groups, whereas there was no significant difference of median NLR between the two groups (2.77 vs. 2.79; p=0.438). No correlation was found between the NLR, PLR, and CEA level values with the location of CRC (p-values 0.978, 0.511,  0.419, respectively). PLR and CEA values were higher in metastatic CRC than in non-metastatic CRC, while NLR value was not significantly different. There was no correlation between the NLR, PLR, and CEA level values with the CRC site.
CD64 and I/T Ratio as a Diagnostic Test on Neonatal Sepsis in Banjarmasin
Authors: Pratiwi Dewi Indah Noviana , Nurikhwan Pandji Winata , Firdaus Muhammad Naufal
Published: February 2024

Neonatal sepsis remains a major problem in the service and care of neonates. The clinical features of neonatal sepsis are non-specific, which makes it difficult to diagnose. The primary objective of this study was to assess the clinical use of cluster of differentiation 64 as a diagnostic marker of neonatal infection. This research used an analytical observational study. The research subjects consisted of 43 samples of neonates at Ulin Hospital, Banjarmasin who had met the inclusion criteria. The results of the study concluded that there was no significant difference between the I/T ratio and cluster of differentiation 64 values in patients with suspected neonatal sepsis with the gold standard procalcitonin and/or blood culture at Ulin Hospital with p=0.874 for the I/T ratio and p=0.285 for cluster of differentiation 64. The diagnostic test for the I/T ratio with a cut-off of 0.2 showed a sensitivity of 23.8%, specificity of 72.7%, positive predictive value of 45.5%, negative predictive value of 50%, mean of 0.16, and median of 0.11. The results of the cluster of differentiation 64 diagnostic test with a cut-off of 2025 showed a sensitivity of 42.9%, specificity of 72.7%, positive predictive value of 81.8%, negative predictive value of 50%, mean of 2487.93, and median of 1671. There was no significant difference between the I/T ratio and cluster of differentiation 64 values in patients with suspected neonatal sepsis with the gold standard procalcitonin and/or blood culture at Ulin Hospital, Banjarmasin.
The Role of Fibrin Monomer Compared to D-dimer and CRP in Determining COVID-19 Severity
Authors: Iriani Anggraini , Sukorini Usi , Fatina Marsya Kaila , Aflah Naja F , Aiman Sarah A , Gemilang Rizka K , Kamelia Telly
Published: February 2024

Fibrin Monomer (FM), as a product of thrombin activity in cleaving fibrinogen, can be used as an early marker of thrombotic events in COVID-19 patients. D-dimer is a commonly used marker of hemostasis as a product of plasmin activity in cleaving polymeric fibrin. D-dimer is often used to help decide whether to initiate anticoagulant administration. This study aims to know whether FM can be used as a marker for thrombotic events such as D-dimer in COVID-19 patients; CRP levels were also examined to determine how inflammation affected the two hemostatic indicators. A total of 93 patients were confirmed with COVID-19 by PCR. The median (min-max) FM in the severe stage was 4.53 (2.26-58.20)ug/mL, whereas, in the mild-moderate stage, it was 4.21 (2.19-32.35 ug/mL. There are significant differences in median D-dimer levels in severe stages to mild-moderate, respectively 0.46 (0.14–7.58) and 0.7890, and ages. The level of FM that can be used to differentiate the severe stage  is > 4.46 ug/mL (sensitivity 56.3%, specificity 58.0%) as in the D-dimer level is > 0.58 ug/mL ((sensitivity 75.0%, specificity 65.2%). There is a moderate positive correlation between fibrin monomer and D-dimer, a weak positive correlation between D-dimer and CRP, and no correlation between FM and CRP. This study concludes that the FM median level is higher in severe COVID-19 than in D-dimer. Fibrin monomer levels have a positive correlation with D-dimer. Fibrin Monomer levels are not affected by CRP.
Comparative Analysis of C-Reactive Protein and Procalcitonin Levels in the Severity of COVID-19 Patients
Authors: Alawiyah Tuti , Nurulita Asvin , Bahrun Uleng
Published: February 2024

Coronavirus Disease 2019 (COVID-19) is a systemic disease characterized by mild to critical symptoms with a high risk of mortality. Fast and precise inflammatory markers are needed to predict the severity and prognosis of COVID-19 to decrease the mortality rate. The elevated levels of C-Reactive Protein (CRP) and procalcitonin may predict an increased risk of aggravation in COVID-19 patients.  This study aimed to analyze the CRP and procalcitonin levels of COVID-19 severity. This was a cross-sectional retrospective study involving 160 COVID-19 patients at Dr. Wahidin Sudirohusodo Hospital. Subjects were grouped based on the severity of COVID-19 (mild, moderate, severe, critical). The difference in CRP and procalcitonin levels based on the severity of COVID-19 was analyzed using the Kruskal-Wallis test and the Spearman correlation test. The age of participants in this study ranged from 19-87 years old. The higher CRP and procalcitonin level shows heavier the severity of COVID-19 (p<0.001). This indicated a significant difference between CRP, procalcitonin levels, and the severity of COVID-19. This study showed that there was a significant correlation between CRP and procalcitonin with the severity of COVID-19, CRP (p<0.001) and procalcitonin (p<0.001).