bluuebunny/crossref_metadata_2025 huggingface dataset:
Multiple system atrophy is distinguished from idiopathic Parkinson's disease by the arginine growth hormone stimulation test
Authors: Pellecchia Maria Teresa , Longo Katia , Pivonello Rosario , Lucetti Claudio , Marchese Roberta , Spampani Annalisa , Manfredi Michela , Epifanio Antonio , Sensi Mariachiara , Scaravilli Tomaso , Bracco Fulvio , Eleopra Roberto , Morgante Letterio , Donati Edoardo , Marconi Roberto , Abbruzzese Giovanni , Bonuccelli Ubaldo , Zappia Mario , Colao Annamaria , Barone Paolo
Published: September 2006

Objective

Multiple system atrophy (MSA) may be difficult to distinguish from idiopathic Parkinson's disease (PD). Our aim was to evaluate the accuracy of the arginine growth hormone (GH) stimulation test in distinguishing between MSA and PD in large populations of patients.

Methods

We measured the GH response to arginine in 69 MSA (43 MSAp [parkinsonism as the main motor feature] and 26 MSAc [cerebellar features predominated]) patients, 35 PD patients, and 90 healthy control subjects. We used receiver‐operating curve analysis to establish the arginine cutoff value that best differentiated between MSA and PD.

Results

The GH response to arginine was significantly lower (p < 0.01) in MSA than in either PD patients or control subjects. At a cutoff level of 4μg/L, arginine distinguished MSAp from PD with a sensitivity and specificity of 91% and MSAc from PD with a sensitivity of 96% and specificity of 91%. The arginine test had a positive predictive value for MSA of 95%. The GH response to arginine was not affected by disease duration or severity, MSA motor subtype, pyramidal signs, response to dopaminergic therapy, or magnetic resonance imaging findings.

Interpretation

The GH response to arginine differentiates MSA from PD with a high diagnostic accuracy. The results suggest an impairment of cholinergic central systems modulating GH release in MSA. Ann Neurol 2006
Effect of pH on biological phosphorus uptake
Authors: Serralta J. , Ferrer J. , Borrás L. , Seco A.
Published: September 2006

An anaerobic aerobic laboratory scale sequencing batch reactor (SBR) was operated to study the effect of pH on enhanced biological phosphorus removal. Seven steady states were achieved under different operating conditions. In all of them, a slight variation in the pH value was observed during anaerobic phase. However, pH rose significantly during aerobic phase. The increase observed was due to phosphorus uptake and carbon dioxide stripping. When pH was higher than 8.2–8.25 the phosphorus uptake rate clearly decreased. The capability of Activated Sludge Model No. 2d (ASM2d) and Biological Nutrient Removal Model No. 1 (BNRM1) to simulate experimental results was evaluated. Both models successfully characterized the enhanced biological phosphorus removal performance of the SBR. Furthermore, BNRM1 also reproduced the pH variations observed and the decrease in the phosphorus uptake rate. This model includes a switch function in the kinetic expressions to represent the pH inhibition in biological processes. The pH inhibition constants related to polyphosphate storage process were obtained by adjusting model predictions to measured phosphorus concentrations. On the other hand, pH inhibition should be included in ASM2d to accurately simulate experimental phosphorus evolution observed in an A/O SBR. © 2006 Wiley Periodicals, Inc.
Synthesis of Novel Rod‐Shaped and Star‐Shaped Fluorescent Phosphane Oxides—Nonlinear Optical Properties and Photophysical Properties
Authors: Ha‐Thi Minh‐Huong , Souchon Vincent , Hamdi Abdelwaheb , Métivier Rémi , Alain Valérie , Nakatani Keitaro , Lacroix Pascal G. , Genêt Jean‐Pierre , Michelet Véronique , Leray Isabelle
Published: September 2006

The design of a new class of fluorophores is presented. Some push–pull chromophores (D–π–A) containing polyphenylethynyl units and a phosphane oxide moiety were efficiently prepared from common intermediates. Straightforward syntheses gave novel one‐armed, rod‐shaped and three‐armed, star‐shaped fluorophores. The optical properties of the resulting star‐shaped derivatives were evaluated, showed high fluorescence quantum yields, and their excitation induces very efficient charge redistribution. Moreover, thanks to their push–pull character, the molecules exhibited significant second‐order NLO properties with good transparency, up to 67⋅10−30esu at 1907 nm, with an absorptionλmaxat 369 nm. The effect of the donor group and of the number of phenylethynyl arms have been studied in this work.
Phase Stability and Site Preference of the Disordered TbCu7‐Type Compound PrCo7‐xTx (T: Ti, Zr, Hf, Cu)
Authors: Wang Gang , Chen Nan‐Xian , Shen Jiang
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Crystal Structure and Specific Heat of GdCuGe.
Authors: Rayaprol Sudhindra , Sebastian C. Peter , Poettgen Rainer
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Sr4PbPt4O11, the First Platinum Oxide Containing Pt26+ Ions.
Authors: Renard Catherine , Roussel Pascal , Rubbens Annick , Daviero‐Minaud Sylvie , Abraham Francis
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Crystal Structure of Mg2B24C, a New Boron‐Rich Boride Related to “Tetragonal Boron I”.
Authors: Adasch Volker , Hess Kai‐Uwe , Ludwig Thilo , Vojteer Natascha , Hillebrecht Harald
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Lithium Intercalation into the Titanosilicate Sitinakite.
Authors: Milne Nicholas A. , Griffith Christopher S. , Hanna John V. , Skyllas‐Kazacos Maria , Luca Vittorio
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Thermal Activation of Methane by Tetranuclear [V4O10]+.
Authors: Feyel Sandra , Doebler Jens , Schroeder Detlef , Sauer Joachim , Schwarz Helmut
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis, Crystal Structure and Spectroscopy Properties of Na3AZr(PO4)3 (A: Mg, Ni) and Li2.6Na0.4NiZr(PO4)3 Phosphates.
Authors: Chakir M. , El Jazouli A. , de Waal D.
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Structure of a Two‐Dimensional Vanadium Tellurite, [H2en][VTeO5]2.
Authors: Jung Kyungna , Kim Hyejin , Yun Hoseop , Do Junghwan
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Methanolothermal Synthesis of [Mn(en)3] [Mn2(SbSe4)2(en)4 (H2O)] and [Mn(en)3] [{Mn(en)2(H2O)}2(μ‐SbSe4)] [Mn(μ‐SbSe4)(en)2]Cl2 Representing the First Example of a Transition Metal‐Containing Ternary Catena‐Selenidoantimonate(V).
Authors: van Almsick Tobias , Sheldrick William S.
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Ag2Te2O7, a Novel Silver Tellurate of Weberite Structure Type.
Authors: Klein Wilhelm , Curda Jan , Peters Eva‐Maria , Jansen Martin
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Chiral Ag‐Based Catalyst for Practical, Efficient, and Highly Enantioselective Additions of Enolsilanes to α‐Ketoesters.
Authors: Akullian Laura C. , Snapper Marc L. , Hoveyda Amir H.
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Sequential Ru—Pd Catalysis: A Two‐Catalyst One‐Pot Protocol for the Synthesis of N‐ and O‐Heterocycles.
Authors: Trost Barry M. , Machacek Michelle R. , Faulk Brian D.
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Chiral 4‐Phenyl‐2‐trifluoromethyloxazolidine: A High‐Performance Chiral Auxiliary for the Alkylation of Amides.
Authors: Tessier Arnaud , Pytkowicz Julien , Brigaud Thierry
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Rhodium‐Catalyzed Addition of Arylboron Compounds to Nitriles, Ketones, and Imines.
Authors: Ueura Kenji , Miyamura Sawako , Satoh Tetsuya , Miura Masahiro
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Palladium‐Catalyzed [3 + 3] Cycloaddition of Trimethylenemethane with Azomethine Imines.
Authors: Shintani Ryo , Hayashi Tamio
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
New, General, and Practical Enamine Cyclopropanation Using Dichloromethane.
Authors: Tsai Chia‐Chung , Hsieh I‐Lin , Cheng Tsung‐Ting , Tsai Ping‐Kuei , Lin Kuo‐Wei , Yan Tu‐Hsin
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
PtCl2‐Catalyzed Rearrangement of Methylenecyclopropanes.
Authors: Fuerstner Alois , Aissa Christophe
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Efficient and Selective Cleavage of Silyl Ethers with Antimony Trichloride.
Authors: Wu Qinpei , Wang Yuan , Chen Wei , Wang Hao , Liu Hua
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Captured and Cross‐Linked Palladium Nanoparticles.
Authors: Cho Jin Ku , Najman Romain , Dean Tony W. , Ichihara Osamu , Muller Christophe , Bradley Mark
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Efficient Microwave and Phosphane‐Free Synthesis of Trisubstituted Olefins via Heck Coupling.
Authors: Collina Simona , Urbano Mariangela , Magnani Andrea , Loddo Guya , Azzolina Ornella
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
One‐Pot Synthesis of Oxo Acid Derivatives by RhI‐Catalyzed Chelation‐Assisted Hydroacylation.
Authors: Jo Eun‐Ae , Jun Chul‐Ho
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
SiO2/N2O4 and Fe(NO3) 3×9H2O/H3PMo12 O40×xH2O Systems as Powerful Oxidants for Removal of Cyclic Dioxalanes and Dithianes.
Authors: Zolfigol Mohammad Ali , Mohammadpoor‐Baltork Iraj , Khazae Ardeshir , Shiri Morteza , Tanbakouchian Zahra
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Solid Phase Regeneration of Carbonyl Compounds by Oxidative Cleavage of Carbon‐Nitrogen Double Bonds with Molecular Oxygen at Room Temperature.
Authors: Hashemi Mohammed M. , Akhbari Maryam , Karimi‐Jaberi Zahed
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
One‐Pot Synthesis of β‐Hydroxy‐1,3‐dienes via Allyltriphenylphosphonium Isomerization under Mild Conditions.
Authors: Sellanes Diver , Scarone Laura , Manta Eduardo , Wipf Peter , Serra Gloria
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
(R)‐6,6′‐Bis(trifluoromethanesulfonyl)‐2,2′‐dihydroxy‐1,1′‐binaphthyl: A New Ligand for Asymmetric Synthesis.
Authors: Mouhtady Omar , Gaspard‐Iloughmane Hafida , Laporterie Andre , Le Roux Christophe
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Pinacol Coupling of Aromatic Aldehydes Using TiCl3—Al—H2O under Ultrasound Irradiation.
Authors: Lin Zhi‐Ping , Li Ji‐Tai , Li Tong‐Shuang
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Convenient Preparation of Aliphatic and Aromatic N‐Sulfonylimines Mediated by Sulfamic Acid in Aqueous Media.
Authors: Li Zhenjiang , Ren Xinghua , Wei Ping , Wan Honggui , Shi Yuhu , Ouyang Pingkai
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Oxidation of Aromatic Compounds. Part 14. Oxidation of Arylethynyl Ketones in the System CF3CO2H—CH2Cl2 —PbO2.
Authors: Aristov S. A. , Vasil'ev A. V. , Rudenko A. P.
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of New Phytogrowth‐Inhibitory Substituted Aryl‐p‐benzoquinones.
Authors: Barbosa Luis Claudio de Almeida , de Alvarenga Elson Santiago , Demuner Antonio Jacinto , Virtuoso Luciano Sindra , Silva Antonio Alberto
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of 2‐Amino‐5‐chlorobenzonitrile.
Authors: Mahajan S. S. , Mahalakshmi A.
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
An Improved Protocol for Ligandless Suzuki—Miyaura Coupling in Water.
Authors: Korolev Dmitrii N. , Bumagin Nikolay A.
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Au(I)‐Catalyzed Tandem [3,3] Rearrangement—Intramolecular Hydroarylation: Mild and Efficient Formation of Substituted Indenes.
Authors: Marion Nicolas , Diez‐Gonzalez Silvia , de Fremont Pierre , Noble April R. , Nolan Steven P.
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Titanium—Salan‐Catalyzed Asymmetric Epoxidation with Aqueous Hydrogen Peroxide as the Oxidant.
Authors: Sawada Yuji , Matsumoto Kazuhiro , Kondo Shoichi , Watanabe Hisayuki , Ozawa Tomoyuki , Suzuki Kenji , Saito Bunnai , Katsuki Tsutomu
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A New Process for the Synthesis of Aurones by Using Mercury (II) Acetate in Pyridine and Cupric Bromide in Dimethyl Sulfoxide.
Authors: Agrawal Nitin N. , Soni P. A.
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Furan Ring Opening—Furan Ring Closure: Cascade Rearrangement of Novel 4‐Acetoxy‐9‐furylnaphtho[2,3‐b]furans.
Authors: Mel'chin Vladimir V. , Butin Alexander V.
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Influence of β‐Cyclodextrin on Coupling Reactions of o‐Nitrobenzenediazonium Salt with Pyrrole.
Authors: Jamrogiewicz M. , Biernat J. F.
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Rapid and Highly Efficient One‐Pot Methodology for Preparation of Alkyl Oxindolideneacetates.
Authors: Azizian Javad , Mohammadizadeh Mohammad Reza , Kazemizadeh Zahra , Karimi Narges , Mohammadi Ali Asghar , Karimi Ali R. , Alizadeh Abdollah
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Chemoselective Benzylic C—H Activations for the Preparation of Condensed N‐Heterocycles.
Authors: Ren Hongjun , Knochel Paul
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Transformation of 1,2‐Dithiole‐3‐thiones into 1,6,6aλ4‐Trithiapentalenes via Reaction with Bromoethanones.
Authors: Cmelik Richard , Pazdera Pavel
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis, Antiviral and Antitumor Activity of New 4‐Nitroimidazoles.
Authors: Al‐Masoudi Najim A. , Al‐Soud Yaseen A. , Kalogerakis Aris , Pannecouque Christophe , De Clercq Erik
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
K2CO3‐Mediated Regioselective Synthesis of Isoxazoles and Pyrazolines.
Authors: Kidwai Mazaahir , Kukreja Shuchi , Thakur Ruby
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Microwave‐Mediated Efficient Protection of Carbonyl Compounds as 1,3‐Oxathiolanes in the Presence of Iodine under Solvent‐Free Condition.
Authors: Bez Ghanashyam , Baruah Nabajyoti
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Heteroaryl Substituted Bis‐trifluoromethyl Carbinols as Malonyl‐CoA Decarboxylase Inhibitors.
Authors: Cheng Jie‐Fei , et al. et al.
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of 5‐Substituted‐1,3,4‐oxadiazole‐2(3H)‐thiones under Microwave Irradiation.
Authors: Khan Khalid Mohammed , Shahzad Sohail Anjum , Rani Mubeen , Ali Muhammad , Perveen Shahnaz , Anwar Awais , Voelter Wolfgang
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of 3‐Amino‐1‐aryl‐9‐methoxy‐5,6‐dihydro‐1H‐benzo [f]chromene‐2‐carbonitriles in Aqueous Media.
Authors: Shi Da‐Qing , Yu Chen‐Xia , Zhuang Qi‐Ya , Wang Xiang‐Shan
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Reduction of 4‐Fluoro‐5‐(1,1,2,2‐tetrafluoroethyl)‐3H‐1,2‐dithiole‐3‐thione with Sodium Sulfide: Synthesis of Fluoro‐Containing Sulfur‐Rich Heterocycles.
Authors: Fesun Igor M. , Rozhenko Alexander B. , Timoshenko Vadim M.
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Design, Synthesis, and Calcium Channel Antagonist Activity of New 1,4‐Dihydropyridines Containing 4‐(5)‐Chloro‐2‐ethyl‐5‐(4)‐imidazolyl Substituent.
Authors: Davood Asghar , Mansouri Niloufar , Dehpour Ahmad Rerza , Shafaroudi Hamed , Alipour Eskandar , Shafiee Abbas
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis with Improved Yield and Study on the Analgesic Effect of 2‐Methoxyphencyclidine (IX).
Authors: Ahmadi Abbas , Mahmoudi Ali
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Efficient Solvent‐Free Synthesis of Quinolines Promoted by BiCl3.
Authors: Jia Cheng‐Sheng , Wang Guan‐Wu
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Highly Enantioselective Broensted Acid Catalyzed Cascade Reaction: Organocatalytic Transfer Hydrogenation of Quinolines and Their Application in the Synthesis of Alkaloids.
Authors: Rueping Magnus , Antonchick Andrey P. , Theissmann Thomas
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Stereoselective Synthesis of the Optical Isomers of a New Muscarinic Receptor Antagonist, Quinuclidin‐3‐yl 2‐(Cyclopent‐1‐enyl)‐2‐hydroxy‐2‐phenylacetate.
Authors: Liu Yu‐Min , Liu He , Zhong Bo‐Hua , Liu Ke‐Liang
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Development of N‐2,4‐Pyrimidine‐N‐phenyl‐N′‐alkyl Ureas as Orally Active Inhibitors of Tumor Necrosis Factor Alpha (TNF‐α) Synthesis. Part 2.
Authors: Brugel Todd A. , et al. et al.
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Biological Investigation of S‐Aryl‐S‐DABO Derivatives as HIV‐1 Inhibitors.
Authors: Mugnaini Claudia , Manetti Fabrizio , Este Jose A. , Clotet‐Codina Imma , Maga Giovanni , Cancio Reynel , Botta Maurizio , Corelli Federico
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Thiazolo[5,4‐f]quinazolin‐9‐ones, Inhibitors of Glycogen Synthase Kinase‐3.
Authors: Testard Alexandra , Loge Cedric , Leger Benoit , Robert Jean‐Michel , Lozach Olivier , Blairvacq Melina , Meijer Laurent , Thiery Valerie , Besson Thierry
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
New Potential Inhibitors of Cyclin‐Dependent Kinase 4: Design and Synthesis of Pyrido[2,3‐d]pyrimidine Derivatives under Microwave Irradiation.
Authors: Tu Shujiang , Zhang Jinpeng , Zhu Xiaotong , Xu Jianing , Zhang Yan , Wang Qian , Jia Runhong , Jiang Bo , Zhang Junyong
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Novel Mercaptoacetylative Expeditious Annulation of 5‐Mercaptopyrimidine Ring on Azoles Using 1,3‐Oxathiolan‐5‐one.
Authors: Yadav Lal Dhar S. , Rai Vijai K. , Yadav Seema
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Some Novel 5,6‐Dihydro‐6‐[4′‐substituted phenyl]‐12H‐indeno[2,1‐c]‐1, 5‐benzodiazepin‐7‐ones.
Authors: Aggarwal Preeti , Kamboj Ramesh C. , Gupta Satish C. , Dhawan Som N.
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Novel Synthesis and Stereochemical Structure of 2H‐2,6‐Methano‐1,3‐benzoxazocine‐5‐carbohydrazides.
Authors: Girgis Adel S. , Hosni Hanaa M.
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Trimethylsilylpropynoyl Chloride.
Authors: Medvedeva A. S. , Andreev M. V. , Safronova L. P. , Afonin A. V.
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Stereoselective Synthesis of 1,3‐Oxazolines by the Reaction of Steroidal Oxiranes with Acetamide.
Authors: Sharma Kamlesh , Saleem Kishwar , Salim Anwar
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Microwave‐Enhanced Nucleophilic Fluorination in the Synthesis of Fluoropyridyl Derivatives of [3,2‐c]Pyrazolo‐corticosteroids, Potential Glucocorticoid Receptor‐Mediated Imaging Agents.
Authors: Kahn Michael G. C. , Konde Emmanuel , Dossou Francis , Labaree David C. , Hochberg Richard B. , Hoyte Robert M.
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Privileged Structure Based Ligands for Melanocortin‐4 Receptors—Aliphatic Piperazine Derivatives.
Authors: de Fructos Oscar , et al. et al.
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Asymmetric [1,2] Stevens Rearrangement of (S)‐N‐Benzylic Proline‐Derived Ammonium Salts under Biphasic Conditions.
Authors: Tayama Eiji , Nanbara Shintaro , Nakai Takeshi
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
High Pressure and Chemical Bonding in Materials Chemistry
Authors: Demazeau Gerard
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Rational Design and Convenient Synthesis of a Novel Family of Ruthenium Complexes with O,N‐Bidentate Ligands
Authors: Drozdzak Renate , Ledoux Nele , Allaert Bart , Dragutan Ileana , Dragutan Valerian , Verpoort Francis
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
New Complexes of Lanthanoids with Unusual Main Group Ligands
Authors: Jones Richard A. , Yang Xiaoping , Waheed Abdul , Wiester Michael , Zhang Lilu
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Stereoselective Michael Addition of Formaldehyde N,N‐Dialkylhydrazones to α,β.‐Unsaturated Carbonyl Compounds
Authors: Diez Elena , Fernandez Rosario , Lassaletta Jose M. , Martin‐Zamora Eloisa , Vazquez Juan
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Nucleophilic Trialkylstannyl and Allyl Transfer Reactions, Catalyzed by Palladium(II) Pincer Complexes
Authors: Malinakova Helena C.
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The Organic Chemistry of Diatomic Sulfur
Authors: Abu‐Yousef Imad
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The Intermolecular C—C Bond Formation by Catalytic Asymmetric C—H Activation
Authors: Shen Hong
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Element—Element Additions to Unsaturated Carbon—Carbon Bonds Catalyzed by Transition Metal Complexes
Authors: Beletskaya Irina , Moberg Christina
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Studies on Total Synthesis of the Cylindricine/Fasicularin/Lepadiformine Family of Tricyclic Marine Alkaloids
Authors: Weinreb Steven M.
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Melanin‐Concentrating Hormone‐1 Receptor Antagonists for the Treatment of Obesity.
Authors: Handlon Anthony L. , Zhou Huiqiang
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Unusual Amino Acids — Synthesis and Introduction into Naturally Occurring Peptides and Biologically Active Analogues
Authors: Cardillo G. , Gentilucci L. , Tolomelli A.
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Coordination Chemistry of Cyanosubstituted Phosphines
Authors: Odinets Irina L. , Vinogradova Natalya M. , Matveeva Ekaterina V. , Mastryukova Tatyana A.
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Phosphinous Acid—Boranes
Authors: Pietrusiewicz K. Michal , Stankevic Marek
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Advances in Methods and Algorithms in a Modern Quantum Chemistry Program Package
Authors: Head‐Gordon Martin , et al. et al.
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Chemical Stereodynamics: Retrospect and Prospect
Authors: Herschbach D.
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Protocols for the Analysis of Theoretical Optical Rotations
Authors: Polavarapu Prasad L.
Published: September 2006

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Towards the Development of Mixed MT1‐Agonist/MT2‐Antagonist Melatonin Receptor Ligands
Authors: Spadoni Gilberto , Bedini Annalida , Guidi Tomaso , Tarzia Giorgio , Lucini Valeria , Pannacci Marilou , Fraschini Franco
Published: September 2006

Herein we report attempts to optimize the pharmacological properties of 5‐(2‐hydroxyethoxy)‐N‐acetyltryptamine (5‐HEAT), a melatonin receptor ligand previously described by us. Several 5‐substituted and 2,5‐disubstituted N‐acyltryptamines were synthesized and evaluated in vitro for the human cloned MT1 and MT2 receptors. From this series of N‐acyltryptamines the 2‐bromo derivative (5 c) retains the interesting efficacy profile of 5‐HEAT and shows increased melatonin receptor affinities; it represents one of the first examples of a high‐affinity MT1 agonist/MT2 antagonist. Some other full agonists for both melatonin receptors which exhibit similar or increased affinity relative to that of melatonin were obtained.
Properties of Hydration Shells of Protein Molecules at their Pressure‐ and Temperature‐Induced Native‐Denatured Transition
Authors: Danielewicz‐Ferchmin Irena , Banachowicz Ewa M. , Ferchmin A. Ryszard
Published: September 2006

Properties of water at the surface of biomolecules are important for their conformational stability. The behaviour of hydrating water at protein transition (t) pressures Pt and temperatures Tt , with the points (Pt,Tt ) lying in the Native–Denatured (N‐D) transition line, is studied. Hydration shells at the hydrophilic regions of protein molecules with surface charge density σ are investigated with the help of the equation of state of water in an open system. The local values of σ rather close to each other (σD ≈0.3 C m−2) are found for six different experimental lines of the N‐D transition found in the literature. The values σD correspond to the crossings of the total pressure (Pt+Π) vs σ isotherms at different Tt (Π−electrostriction pressure). The pressures Pt and temperatures Tt appear to be related with some selected sites at the surfaces of the protein molecules.
Developmental expression of the chick four‐jointed homologue
Authors: Yamaguchi Kumiko , Parish Joanne , Akita Keiichi , Francis‐West Philippa
Published: September 2006

Four‐jointed is a type II transmembrane protein that is thought to be cleaved to give rise to a secreted protein. In Drosophila, four‐jointed controls outgrowth, vein patterning, and bristle polarity in the developing limb together with the polarity of the ommatidia in the developing eye. In Drosophila and mice, Fj is regulated by notch signaling. Here, we have determined the expression of the chick four‐jointed (fjx) homologue during embryonic development. We show that fjx is expressed in the limb bud; facial primordia; the proliferating zone of the lens, feather buds, the neural tube; and neural crest derivatives such as the dorsal root ganglia. Analysis of the fjx expression in the developing limb bud showed that initially fjx is expressed throughout the limb bud, but as the limb develops, highest levels of fjx transcripts are found distally. However, by stage 27, fjx expression is predominantly found in the central core of the limb bud. Finally, fjx expression becomes confined to the developing tendons, ligaments, articular cartilage, and arteries but not the veins. Comparison with scleraxis (scx), a marker of tendons and ligaments, revealed that they are coexpressed in the majority of tendons but that fjx is expressed after scx, when the tendons have begun to differentiate. These data suggest that fjx has two roles during limb development: the first controlling outgrowth and the second tissue differentiation. Developmental Dynamics 235:3085–3091, 2006. © 2006 Wiley‐Liss, Inc.
Time‐lapse tracing of mitotic cell divisions in the early Xenopus embryo using microscopic MRI
Authors: Papan Cyrus , Boulat Benoit , Velan S. Sendhil , Fraser Scott E. , Jacobs Russell E.
Published: September 2006

Mitotic cell division is a highly regulated cellular event in all organisms, but its direct visualization in the vertebrates is limited to animals with transparent embryos. Here, we report on the use of microscopic magnetic resonance imaging (mMRI) to noninvasively observe mitotic cell division of early blastomeres in the optically opaque Xenopus laevis embryo. Due to intrinsic tissue contrast, cell nuclei can be directly visualized without the need for contrast enhancing labeling. By taking two‐dimensional in vivo time‐lapse image sequences, the karyokinesis of a blastomere is followed. Timing and orientation of the cleavages can be traced for five cell divisions to establish a cell lineage tree, including orientation and timing of the mitosis. This work demonstrates for the first time the use of MRI for the visualization of cell divisions and expands the experimental scope of the Xenopus embryo. Developmental Dynamics 235:3059–3062, 2006. © 2006 Wiley‐Liss, Inc.
Nitric oxide and peroxynitrite have different antiviral effects against hantavirus replication and free mature virions
Authors: Klingström Jonas , Åkerström Sara , Hardestam Jonas , Stoltz Malin , Simon Melinda , Falk Kerstin I. , Mirazimi Ali , Rottenberg Martin , Lundkvist Åke
Published: September 2006

Reactive nitrogen intermediates (RNI), like nitric oxide (NO) and peroxynitrite, have antiviral effects against certain viruses. Hantaviruses, like other members of the Bunyaviridae family, have previously not been shown to be sensitive to RNI. In this study, we compared the effects of NO and peroxynitrite on hantavirus replication and free mature virions in vitro, and of inducible nitric oxide synthase (iNOS) in hantavirus‐infected suckling mice. The NO‐generating compound S‐nitroso‐N‐acetylpenicillamine (SNAP), as well as cytokine‐induced NO, strongly inhibited hantavirus replication in Vero E6 cells, while pretreatment of free virions with SNAP only had a limited effect on their viability. In contrast, 3‐morpholinosydnonimine hydrochloride (SIN‐1), a peroxynitrite donor, inhibited virus replication only to a very low extent in vitro, but pretreatment of virus with SIN‐1 led to a considerably lowered viability of the virions. Infections of various human cell types per se did not induce NO production. The viral titers in iNOS–/– mice were higher compared to the controls, suggesting that NO inhibits hantavirus replication in vivo. In conclusion, we show that NO has strong antiviral effects on hantavirus replication, and peryoxynitrite on mature free virions, suggesting that different RNI can have different effects on various parts of the replication cycle for the same virus.
T and B lymphocytes exert distinct effects on the homeostasis of NK cells
Authors: Jeannet Grégoire , Coudert Jérôme D. , Held Werner
Published: September 2006

There is growing evidence that lymphocytes impact the development and/or function of other lymphocyte populations. Based on such observations we have tested whether the NK cell compartment was phenotypically and functionally altered in the absence of B and/or T cells. Here we show that T cell deficiency significantly accelerates BM NK cell production and the subsequent seeding of splenic and liver NK cell compartments. In contrast, B cell deficiency reduces splenic NK cell survival. In the absence of T and B cells, the size of the NK cell compartments is determined by the combination of these positive and negative effects. Even though NK cell homeostasis is significantly altered, NK cells from T and/or B cell‐deficient mice show a normal capacity to kill a susceptible target cell line and to produce IFN. Nevertheless, we noted that the usage of MHC class I‐specific Ly49 family receptors was significantly altered in the absence of T and/or B cells. In general, B cell deficiency expanded Ly49 receptor usage, while T cell deficiency exerted both positive and negative effects. These findings show that B and T cells significantly and differentially influence the homeostasis and the phenotype of NK cells.
Decolorizing Reactive Textile Dyes with White‐Rot Fungi by Temporary Immersion Cultivation
Authors: Boehmer U. , Suhardi S. H. , Bley T.
Published: September 2006

The decontamination of effluents from textile industries is problematic due to the fact that textile dyes are resistant to degradation in the environment. Enzymes from white rot fungi, especially laccase, are able to degrade various complex aromatic structures, and are therefore able to decolorize textile dyes. The white‐rot fungi Trametes versicolor and Phanerochaete chrysosporium were immobilized, separately, on both pine wood chips and palm oil fiber, and cultivated in the temporary immersion RITA® (Récipient à Immersion Temporaire Automatique) System, which was adapted to serve as a fungal bioreactor in a series of four experiments to determine optimal conditions for decolorizing the textile dyes Levafix Blue and Remazol Brilliant Red. The maximum rate of decolorization of both dyes occurred within 24 h of incubation, and laccase was detected in the system.
Acclimation Strategy of a Biohydrogen Producing Population in a Continuous‐Flow Reactor with Carbohydrate Fermentation
Authors: Ren N. Q. , Gong M. L.
Published: September 2006

Poor startup of biological hydrogen production systems can cause an ineffective hydrogen production rate and poor biomass growth at a high hydraulic retention time (HRT), or cause a prolonged period of acclimation. In this paper a new startup strategy was developed in order to improve the enrichment of the hydrogen‐producing population and the efficiency of hydrogen production. A continuously‐stirred tank reactor (CSTR) and molasses were used to evaluate the hydrogen productivity of the sewage sludge microflora at a temperature of 35 °C. The experimental results indicated that the feed to microorganism ratio (F/M ratio) was a key parameter for the enrichment of hydrogen producing sludge in a continuous‐flow reactor. When the initial biomass was inoculated with 6.24 g of volatile suspended solids (VSS)/L, an HRT of 6 h, an initial organic loading rate (OLR) of 7.0 kg chemical oxygen demand (COD)/(m3 × d) and an feed to microorganism ratio (F/M) ratio of about 2–3 g COD/(g of volatile suspended solids (VSS) per day) were maintained during startup. Under these conditions, a hydrogen producing population at an equilibrium state could be established within 30 days. The main liquid fermentation products were acetate and ethanol. Biogas was composed of H2 and CO2. The hydrogen content in the biogas amounted to 47.5 %. The average hydrogen yield was 2.01 mol/mol hexose consumed. It was also observed that a special hydrogen producing population was formed when this startup strategy was used. It is supposed that the population may have had some special metabolic pathways to produce hydrogen along with ethanol as the main fermentation products.
Rationally designed peptides for controlled release of nerve growth factor from fibrin matrices
Authors: Willerth Stephanie M. , Johnson Philip J. , Maxwell Dustin J. , Parsons Sarah R. , Doukas Maria E. , Sakiyama‐Elbert Shelly E.
Published: September 2006

The purpose of this research was to identify peptide sequences with varying affinity for nerve growth factor (NGF) and use them in the rational design of affinity‐based drug delivery systems. A phage display library (12 amino acid random peptide sequence) was screened against NGF‐conjugated chromatography resin three times and fractions containing phage of varying affinity were eluted by decreasing the pH of the eluent. These phages were isolated, amplified; then their DNA was purified and sequenced to determine the identity of the random peptide domain. Consensus peptides based on these sequences were synthesized and screened for their ability to bind NGF and release it at different rates from fibrin matrices. The ability of fibrin matrices containing these peptides and NGF to deliver to biologically active NGF was tested using a chick dorsal root ganglia model. A mathematical model was developed to further understand how the affinity of a peptide can modulate release of NGF and to aid in design optimization for the delivery system. The peptides identified in this study were determined to have varying affinities for NGF suggesting that this approach can serve as a model for tailoring the affinity of a drug delivery system for a target protein drug. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2007