bluuebunny/crossref_metadata_2025 huggingface dataset:
Streben of the I as the Fundamental Form of Consciousness
Authors: Jurić Andrija
Published: December 2021

This paper aims to show that Fichte’s concept of Streben or striving of the I is the necessary condition of finite or individual consciousness. The I posits itself absolutely, but in doing so it posits the not-I as well, therefore it posits itself absolutely as self-limiting I. If there was no limitation on the infinite striving of the I’s activity, then there would be no I, at least as we know it. Firstly, the paper emphasizes why this activity or striving needs to be infinite, and at the same time determined. Then, why is it necessary for theoretical self-consciousness, regarding the idea of Anstoss, divided self and absolute I. Finally, why is it also necessary for practical standpoint, considering the ideas of practical striving, tendency, longing, drive, and desire (both in individual striving towards self-coherence and social drive for intersubjectivity). It will be concluded that the I possesses a “dual nature” or divided character: it is finite, but it strives towards infinity. The tension arising from this contradiction should be the moving force of the I.
Fuentes Quintana y los Pactos de la Moncloa.
Authors: Fernández Luna Manuel
Published: December 2021

El artículo analiza la huella del economista Enrique Fuentes Quintana en la política económica española. La trayectoria profesional del profesor Fuentes pone de manifiesto el desarrollo académico de la ciencia económica en España, país en el que la aplicación práctica de los conocimientos económicos generó importantes avances en su economía. Dentro del complejo contexto histórico de integración política y económica en Europa que España había emprendido en los años 70, le fue encomendada al profesor Fuentes la tarea de articular las respuestas desde la política económica a la situación creada por la crisis del petróleo, lo que se plasmó en los Pactos de la Moncloa. Este trabajo recoge documentos de los años previos a los Pactos sobre el pensamiento económico de Fuentes Quintana y sus opiniones sobre lo que ocurría en la economía italiana, país al que consideraba como referencia práctica para la economía española.
Zur Bedeutung der Didaktik der nicht-linguistischen Disziplinen im FSU
Authors: Besedová Petra
Published: December 2021

IMPORTANCE OF THE DIDACTICS OF NON-LINGUISTIC DISCIPLINES IN FOREIGN LANGUAGE TEACHING Learning does not mean anything but learning with all your senses and feelings. The young generation lives nowadays in a complex media world to which foreign language didactics also has to respond. Educators and teachers should use numerous materials that do not only develop language skills, but also conveycultural approaches. The teaching of non-linguistic disciplines plays a key role in foreign language teaching, and foreign language teaching is currently very modern in its cultural context. The paper attempts to outline the existence of the so-called didactics of non-linguistic disciplines in foreign language teaching in the Czech Republic. On the basis of a questionnaire survey among foreign language teachers, the extent to which foreign language teachers are confronted with the content of didactics of non-language subjects was examined. The authors were also interested whether there are differences between teachers of different foreign languages (English, German, Russian, French), and which preferences teachers of these foreign languages manifest when choosing their teaching material. We believe that the content of the didactics of non-linguistic disciplines is an essential part of foreign language teaching and can greatly enrich this field.
Der erste Sprachkontakt: ein Konzept für die Nachbarsprachenvermittlung im Kindergartenalltag
Authors: Brychová Alice
Published: December 2021

THE FIRST LANGUAGE CONTACT: A CONCEPT FOR TEACHING NEIGHBOURING LANGUAGES IN THE NURSERY SCHOOL In the article we would like to describe the chances and potential of early acquisition of neighbouring languages for child development, and to present the specific possibilities of the “learning location” border region. Specific circumstances have also influenced the methodological approach in the teaching of neighbouring languages for children in Lower Austria nursery schools. The mother tongue staff and the methodical advisors of the project “BIG”, among them also the author of the article, have tried together to develop an optimal concept which would also serve as a basis for teaching or pedagogical care of children at the interface nursery school.
Identification and Evaluation of Technical and Operational Parameters of Mobile Positive Pressure Ventilation Fans Used during Rescue Operations
Authors: Kaczmarzyk Piotr , Klapsa Wojciech , Janik Paweł , Krawiec Piotr
Published: December 2021

Aim: The aim of the article is to indicate the essential technical and operational parameters of mobile fans and to present the proposed testing method- ologies (as well as dedicated infrastructure) allowing to confirm the indicated features. Project and methods: In many places around the world, scientists conduct tests related to the use of mechanical tactical ventilation with the use of mobile positive pressure ventilation fans. These devices are used by fire protection units, among others, for the removal of thermal decomposition products resulting from fires, posing a threat to people staying in construction facilities during events and hindering rescue operations. Achieving the expected effects through the use of mechanical tactical ventilation depends on many factors, among others, on the appropriate technical parameters and the ability to use the fan. Describing the essential features that should be characterized by the devices in question, attention in particular should be paid to: mobility, durability, reliability and effectiveness. To confirm these features, mobile fans should be tested using properly validated test methodologies. This publication presents a draft of the test program that allows to confirm the effectiveness of mobile fans, i.e. aerodynamic efficiency (flow rate), stream shape (area of the effective speed distribution), operating time, noise, weight and dimensions. Conclusions: Mobile fans used by fire protection units are an important tool supporting the effectiveness of rescue operations. However, in order for them to be used in an optimal way, it is necessary to comprehensively examine the technical parameters, and then – adequately to these parameters – to develop appropriate procedures for their use. In the context of the aforementioned testing, despite the large scientific achievements in this field, there are still areas that require improvement, with particular emphasis on standardized testing methodologies and the measurement infrastructure dedicated to them. For this reason, the authors indicated important technical and functional features that determine the effectiveness of mobile fans and recom - mended selected methods on the basis of which these features can be verified. The intention of the project is to provide rescuers with greater comfort when choosing and using the devices in question. The basis for this comfort is to be aware of the availability of equipment with confirmed functional characteristics and the possibility of referring to the developed guidelines for the proper use of fans in accordance with their parameters. Key words: mobile positive pressure ventilation fans, tests of mobile fans, functional properties of fans Article type: review article
Important Parameters and Settings in Unmanned Aerial Vehicles
Authors: Zawistowski Maciej
Published: December 2021

Aim: The article presents a set of parameters and settings for unmanned aerial vehicles (UAV), which is crucial in the operational work of the fire brigade and its importance for the quality of the final material obtained from an RGB camera or a thermal imaging camera. Introduction: Unmanned aerial vehicles (UAVs) are more often and more boldly used by various uniformed formations, including pilots of the State Fire Service and Volunteer Fire Brigades. Currently, they are used to perform recognition of situations and coordination of activities with the use of RGB and thermal imaging cameras. There are also other applications of UAV, including firefighting, but at the moment they are only conceptual solutions, as they have not been tested during an actual firefighting operation. According to the authors, a drone is currently only a carrier of additional devices and its functionality during the operation depends largely on certainty and reliability of a given UAV structure, as well as on the type and quality of the elements and sensors mounted on it. Methodology: A review of literature and press reports, as well as the authors’ experience in working with UAVs and the results of their research were used to analyse the topic. Conclusions: Indicating a set of key parameters for the UAVs used by fire brigade users is only possible to define its application. Therefore, in this study, the authors presented the most common use of unmanned aerial vehicles, for which key parameters were indicated and the impact of these factors on the obtained results of drones was described. Due to the frequent neglect of camera operation and the importance of their parameters, the authors described the most frequently set parameters of photographs and their impact on the final result, which is of key importance for the usefulness of the collected material.
A Digital Twin for Decision Making on Livestock Feeding
Authors: Raba David , Tordecilla Rafael D. , Copado Pedro , Juan Angel A. , Mount Daniel
Published: December 2021

Looking for an accurate and cost-effective solution to measure feed inventories, forecast the feed demand and allow feed suppliers to optimize inventories, production batches, and delivery routes.
Self-Selection of Peers and Performance
Authors: Kiessling Lukas , Radbruch Jonas , Schaube Sebastian
Published: December 2021

This paper studies how the presence of peers and different peer assignment rules—self-selection versus random assignment—affect individual performance. Using a framed field experiment, we find that the presence of a randomly assigned peer improves performance by 28% of a standard deviation (SD), whereas self-selecting peers induces an additional 15%–18% SD improvement in performance. Our results document peer effects in multiple characteristics and show that self-selection changes these characteristics. However, a decomposition reveals that variations in the peer composition contribute only little to the performance differences across peer assignment rules. Rather, we find that self-selection has a direct effect on performance.

This paper was accepted by Yan Chen, decision analysis.

Funding: Funding by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) through CRC TR 224 (projects A01 and A02) is gratefully acknowledged.

Supplemental Material: The online appendix and data are available at https://doi.org/10.1287/mnsc.2021.4267 .
Misdiagnosis of Rectus Abdominis Abscess Owing to Delayed Contrast-Enhanced Computed Tomography
Authors: Nagase Yuichiro , Harada Yukinori
Published: December 2021

A 77-year-old man, who was on anticoagulation, presented with a painful lump on the right abdominal wall. Laboratory tests showed slight anaemia and elevated inflammatory markers. Abdominal plain computed tomography (CT) revealed a mass in the right rectus abdominis muscle. He was admitted with a diagnosis of primary rectus abdominis haematoma. However, on the next day, the diagnosis was corrected to primary rectus abdominis abscess, following contrast-enhanced CT of the abdomen. This case illustrates the importance of considering primary rectus abdominis abscess in patients with suspected primary rectus abdominis haematoma, and contrast should be used when performing CT.
Burnout in frontline ambulance staff
Authors: Beldon Rachel , Garside Joanne
Published: December 2021

Background:

Staff retention is a significant issue for ambulance services across the globe. Exploratory research, although minimal, indicates that stress and burnout, in particular, influence attrition within the paramedic profession. These need to be understood if their impact on retention is to be addressed.

Aims:

To determine the presence of and contributory factors for burnout in the ambulance service to inform recommendations for positive change.

Methods:

A two-phased survey approach was adopted using an adapted Maslach Burnout Inventory and Copenhagen self-assessment burnout questionnaire, to measure levels of burnout, depersonalisation (cynicism) and personal achievement. Open-ended questions explored factors that influenced these. Demographic and comparative analysis identified trends and thematic analysis was carried out on the qualitative data.

Results:

Ninety-four per cent of ambulance staff in this study (n=382) reported a sense of personal achievement within their professional role; however, more than 50% were experiencing varying levels of burnout with 87% displaying moderate or high levels of depersonalisation towards their work. Causes of stress were complex: themes attributed were a perceived lack of management support, the public's misuse of the ambulance service, involuntary overtime and a poor work-life balance.

Conclusions:

Burnout poses a genuine threat to retention in the ambulance service and needs addressing. Proactive screening, better communication between practice staff and management and access to counselling services are recommended. This problem of burnout is beginning to be acknowledged but further evidence is needed to understand it in more depth in order for effective solutions to be developed.
Prescribing errors in general practice
Authors: McCutcheon Jennifer
Published: December 2021

Prescribing errors are relatively common in general practice. Jennifer McCutcheon provides an overview of common prescribing errors and how they can be prevented

Nurses, pharmacists and allied health professionals are increasingly becoming prescribers and many of them work autonomously in general practice. Prescribing professionals have a duty to understand what a prescribing error is, common examples of errors in practice, how they are prevented and how they can be investigated and reported should they occur.
Lack of political recognition for nurses working in general practice
Authors: Oldman Crystal
Published: December 2021

Crystal Oldman highlights the heroic efforts of general practice nurses in delivering the vaccination programme
RESEARCH ROUNDUP
Authors: Winter George
Published: December 2021

George Winter provides an overview of recently published articles that are of interest to practice nurses. Should you wish to look at any of the papers in more detail, a full reference is provided.
Atypical Femoral Fracture in a Patient without Bisphosphonate or Denosumab Exposure-A Case Report
Authors: Georgiadis George F. , Begkas Dimitrios G. , Maniatis Konstantinos A. , Vasilakis Alexandros E. , Chatzopoulos Stamatios Theodoros D. , Balanika Alexia P.
Published: December 2021

Introduction: Atypical femoral fractures (AFF) are associated with the use of bisphosphonates (BPs) or denosumab. However, few cases that meet the characteristics of these fractures, as established by the American Society of Bone and Mineral Research, have occurred in patients who have never used antiresorptive drugs.

Case Report:We report a case of AFF in a 67-year-old woman who had never used antiresorptive medications. The history and comorbidities of the patient, the characteristics of the fracture, and the subsequent treatment are presented.

Conclusion: AFFs may occur even in patients who have never been exposed to BPs or denosumab. The absence of antiresorptive osteoporosis therapy and the lack of radiographic focal periosteal reaction in the lateral femoral cortex, as in our case, can make it difficult to detect and prevent the disorder. Prolonged use of proton pump inhibitors and Vitamin D deficiency-related osteomalacia may contribute to the occurrence of these fractures. Further studies are required to accurately understand all inciting factors contributing to the development of AFFs.

Keywords: Atypical femoral fractures, subtrochanteric fractures, denosumab, bisphosphonates, antiresorptive drugs.
Management of complex femur fractures in children: A report of Three Cases
Authors: Kulkarni Shrihari L , Mannual Sunil , Daragad Manjunath , Patil Naveenkumar , Ernest Daniel
Published: December 2021

Introduction:Complex femur fractures are defined as combined fractures of shaft and proximal of or the distal femur. Restoration of anatomical alignment is the primary goal of the management of these fractures. In this report, we describe the management of complex femur shaft fractures in three pediatric patients.

Case Report: This report includes three patients. The first patient was a 10-year-boy with comminuted proximal femur shaft fracture extending into the subtrochanteric area, managed with minimally invasive sub-muscular plating. The second patient was a 12-year-boy with comminuted femur shaft extending into subtrochanteric area, treated with combined retrograde and anterograde Titanium Elastic Nail System. A 12-year-old boy with femur shaft with intertrochanteric fracture managed with K-wire fixation for intertrochanteric fracture and plating with dynamic compression plate for femur shaft was our third patient. All patients had excellent radiological and functional outcome.

Conclusion: Complex femur shaft fractures in children are very rare and challenging injuries. With proper pre-operative planning and use of appropriate implants excellent outcomes can be obtained.

Keywords:Complex femur fractures, pediatric orthopedics, sub-muscular plating, titanium elastic nailing.
A Transposition Flap Reconstruction after Resection of a Soft-Tissue Sarcoma in the Buttock
Authors: Sakamoto Akio , Noguchi Takashi , Matsuda Shuichi , Matsuda Shuichi
Published: December 2021

Introduction:Large defects following resection in the gluteal region are challenging. Of note, there are a limited number of fairly morbid options for reconstruction.

Case Report:A 65-year-old female presented with complaints of an enlarging mass in the left buttock over the past several months. A high-grade sarcoma was diagnosed based on a biopsy. The final diagnosis was an undifferentiated pleomorphic sarcoma based on the resected tumor. An 11-cm tumor with surrounding tissues, including the great gluteal muscle, was resected, which resulted in a 17-cm full thickness defect. The defect was reconstructed with a transposition flap elevated from the lateral thorax. A transposition flap can cover large buttock defects without sacrificing other muscles.

Conclusion:Moreover, a transposition flap is esthetically acceptable because most of the operative scar is within the buttock area. A transposition flap reconstruction is one of the several options for large defects after soft-tissue sarcoma resection in the buttock.

Keywords:Buttock, resection, reconstruction, musculocutaneous flap, soft-tissue sarcoma.
Report of a Case of Cold Urticaria Following Cryotherapy – Need for Screening for Untoward Effects of Cryotherapy in Physical Therapy Clinical Practice
Authors: Jagadevan Mohanakrishnan , Mohanakrishnan Bhanumathy , Balaji Gopisankar , Munisamy Malathi , Murugesan Salaja , Murugesan Salaja
Published: December 2021

Introduction:Musculoskeletal rehabilitation is one of the frontline domains in physical therapy practice. In most countries, physical therapists prefer independent practice with referrals from general practitioners and orthopedic surgeons. Under these circumstances, the physical therapist may be the first contact professional handling these individuals who may not have adequate medical records with their personal medical history. Cryotherapy for pain relief could be the first choice of pain management opted by a musculoskeletal therapist. That is when both the therapist and the patient have to be aware of the undesirable effects of cryotherapy application and its potential local and systemic complications. The outcome of this paper could be an initiative for a standardized screening process to be incorporated into physical therapy practice.

Clinical Findings:A 30-year-old man with left knee pain who underwent exercise therapy in the physiotherapy unit of a tertiary care center developed erythematous rashes around the knee following ice application. It was noted that the patient was not aware of the same in the past. The patient was attended by a dermatologist, and a diagnosis of cold urticaria was made following confirmation with cold stimulation test.

Conclusion:From this study, it may be concluded that the awareness of cold-induced urticaria has to be emphasized on both patients and health care professionals. A simple screening protocol should be made mandatory in orthopedic physical therapy practice, which would suffice this purpose.

Keywords: Urticaria, cryotherapy, Physical therapy
Quality and flexural strength of laser-cut glass: classical top-down ablation versus water-assisted and bottom-up machining
Authors: Dudutis Juozas , Zubauskas Laimis , Daknys Eimantas , Markauskas Edgaras , Gvozdaitė Rasa , Račiukaitis Gediminas , Gečys Paulius
Published: December 2021

The growing applicability of glass materials drives the development of novel processing methods, which usually lack comprehensive comparison to conventional or state-of-art ones. That is especially delicate for assessing the flexural strength of glass, which is highly dependent on many factors. This paper compares the traditional top-down laser ablation methods in the air to those assisted with a flowing water film using picosecond pulses. Furthermore, the bottom-up cutting method using picosecond and nanosecond pulses is investigated as well. The cutting quality, sidewall roughness, subsurface damage and the four-point bending strength of 1 mm-thick soda-lime glass are evaluated. The flexural strength of top-down cut samples is highly reduced due to heat accumulation-induced cracks, strictly orientated along the sidewall. The subsurface crack propagation can be reduced using water-assisted processing, leading to the highest flexural strength among investigated techniques. Although bottom-up cut samples have lower flexural strength than water-assisted, bottom-up technology allows us to achieve higher cutting speed, taper-less sidewalls, and better quality on the rear side surface and is preferable for thick glass processing.
Underwater quasi-omnidirectional wireless optical communication based on perovskite quantum dots
Authors: Li Xin , Tong Zhijian , Lyu Weichao , Chen Xiao , Yang Xingqi , Zhang Yufan , Liu Songjie , Dai Yizhan , Zhang Zejun , Guo Chaoyang , Xu Jing
Published: December 2021

In this paper, a quasi-omnidirectional transmitter is proposed and demonstrated for underwater wireless optical communication (UWOC) using the photoluminescence of perovskite quantum dots (QDs). The proposed transmitter, without complex driving circuits, is compact and reliable thanks to the lens-free design. The system performance is tested in a 50-m swimming pool with a water attenuation coefficient of 0.38 dB/m. The maximum data rates of on-off-keying (OOK) signals over 10-m and 20-m transmission distances can reach 60 Mbps and 40 Mbps, respectively. When four clients are adopted in a code division multiple access (CDMA) based UWOC network, the maximum data rates of each client can reach 10 Mbps and 7.5 Mbps over 10-m and 20-m underwater channels, respectively. The system can meet the requirements of the last meter end-user access in the Internet of underwater things (IoUT) and underwater optical cellular network systems.
Fabrication of Sb2O3 by an improved chemical reaction assisted vertical micro sublimation method and its saturable absorber performance
Authors: Wang Yuhao , Chen Qiudi , Zhang Peixiong , Liao Jiayu , Hong Hong , Chen Hongling , Yin Hao , Hang Yin , Li Zhen , Chen Zhenqiang
Published: December 2021

Two-dimensional molecular crystals (2DMCs) are emerging ideal materials for future high-performance optoelectronic devices. People are constantly exploring new methods to solve the problem of difficult growth. Here, we design an improved chemical reaction-assisted vertical micro sublimation method based on vertical micro sublimation for the growth of two-dimensional Sb2O3 inorganic molecular crystals for the first time. The saturation absorption characteristics of the self-made Sb2O3 2DMCs were systematically tested, and the Q-switched laser output characteristics of Sb2O3 2DMCs at 1 µm were verified by using Nd: GYAP mixed crystal. The maximum average output power of 231 mW was achieved at 1080.6 nm, corresponding shortest pulse with a duration of 472 ns and maximum pulse repetition rate of 376 kHz. The maximum single pulse energy and the maximum peak power of the laser output were 0.614 µJ and 1.3 W, respectively. The growth of other 2DMCs would be motivated and its potential applications in the field of ultrafast photonics would be expanded with our findings.
High genome plasticity and frequent genetic exchange in Leishmania tropica isolates from Afghanistan, Iran and Syria
Authors: Glans Hedvig , Lind Karlberg Maria , Advani Reza , Bradley Maria , Alm Erik , Andersson Björn , Downing Tim
Published: December 2021

Background

The kinetoplastid protozoanLeishmania tropicamainly causes cutaneous leishmaniasis in humans in the Middle East, and relapse or treatment failure after treatment are common in this area.L.tropica’s digenic life cycle includes distinct stages in the vector sandfly and the mammalian host. Sexual reproduction and genetic exchange appear to occur more frequently than in otherLeishmania species. Understanding these processes is complicated by chromosome instability during cell division that yields aneuploidy, recombination and heterozygosity. This combination of rare recombination and aneuploid permits may reveal signs of hypothetical parasexual mating, where diploid cells fuse to form a transient tetraploid that undergoes chromosomal recombination and gradual chromosomal loss.

Methodology/principal findings

The genome-wide SNP diversity from 22L.tropicaisolates showed chromosome-specific runs of patchy heterozygosity and extensive chromosome copy number variation. All these isolates were collected during 2007–2017 in Sweden from patients infected in the Middle East and included isolates from a patient possessing two genetically distinct leishmaniasis infections three years apart with no evidence of re-infection. We found differing ancestries on the same chromosome (chr36) across multiple samples: matching the reference genome with few derived alleles, followed by blocks of heterozygous SNPs, and then by clusters of homozygous SNPs with specific recombination breakpoints at an inferred origin of replication. Other chromosomes had similar marked changes in heterozygosity at strand-switch regions separating polycistronic transcriptional units.

Conclusion/significance

These large-scale intra- and inter-chromosomal changes in diversity driven by recombination and aneuploidy suggest multiple mechanisms of cell reproduction and diversification inL.tropica, including mitotic, meiotic and parasexual processes. It underpins the need for more genomic surveillance ofLeishmania, to detect emerging hybrids that could spread more widely and to better understand the association between genetic variation and treatment outcome. Furthering our understanding ofLeishmaniagenome evolution and ancestry will aid better diagnostics and treatment for cutaneous leishmaniasis caused byL.tropicain the Middle East.
HPV16 E1 dysregulated cellular genes involved in cell proliferation and host DNA damage: A possible role in cervical carcinogenesis
Authors: Baedyananda Fern , Chaiwongkot Arkom , Varadarajan Shankar , Bhattarakosol Parvapan
Published: December 2021

HPV16 is the most prominent cause of cervical cancer. HPV16 E1, a helicase required for HPV replication exhibits increased expression in association with cervical cancer progression, suggesting that E1 has a similar effect on the host as the HPV16 E6 and E7 oncoproteins. This study aimed to determine whether expression of HPV16 E1 correlated with carcinogenesis by modulating cellular pathways involved in cervical cancer. HEK293T cells were transfected with pEGFP, pEGFPE1 or truncated forms of HPV16 E1. Cell proliferation, cell death, and the impact of HPV16 E1 on host gene expression was then evaluated. HPV16 E1 overexpression resulted in a significant reduction of cell viability and cellular proliferation (p-value<0.0001). Moreover, prolonged expression of HPV16 E1 significantly induced both apoptotic and necrotic cell death, which was partially inhibited by QVD-OPH, a broad-spectrum caspase inhibitor. Microarray, real time RT-PCR and kinetic host gene expression analyses revealed that HPV16 E1 overexpression resulted in the downregulation of genes involved in protein synthesis (RPL36A), metabolism (ALDOC), cellular proliferation (CREB5, HIF1A, JMJDIC, FOXO3, NFKB1, PIK3CA, TSC22D3), DNA damage (ATR, BRCA1 and CHEK1) and immune response (ISG20) pathways. How these genetic changes contribute to HPV16 E1-mediated cervical carcinogenesis warrants further studies.
Path analysis based on genetic association of yield components and insects pest in upland cotton varieties
Authors: Shaheen Mussarat , Abdul Rauf Hafiz , Taj Muhammad Ahmed , Yousaf Ali Muhammad , Bashir Muhammad Amjad , Atta Sagheer , Farooq Hasnain , Alajmi Reem A. , Hashem Mohamed , Alamri Saad
Published: December 2021

Gossypium hirsutum L. is also called upland cotton or Mexican cotton. It is the most widely cultivated species of cotton in the whole world. Globally, about 90% of all cotton production comes from the cultivars derived from this species. Some genetic parameters like monopodial branches per plant, sympodial branches per plant, sympodial branch length, bolls per plant, boll weight, sympo-boll distance, Ginning Out Turn%, staple length (rg = 0.9199**), and fiber strength along with seed cotton yield were evaluated for their potential utilization via selection in seed cotton yield improvement. Significant positive genetic correlations were estimated for monopodial branches per plant (rg = 0.9722**), sympodial branches per plant (rg = 0.7098**), sympodial branch length (rg = 0.617**), bolls per plant (rg = 0.8271**), boll weight (rg = 0.8065**), sympo-boll distance (rg = 0.6507**), Ginning Out Turn (GOT)% (rg = 0.7541**), staple length (rg = 0.9199**), and fiber strength (rg = 0.7534**) with seed cotton yield. A path analysis of all the yield traits under study revealed strong positive direct effects of monopodial branch length (1.1556), sympo-boll distance (0.8173) and staple length (0.7633), while plant height exerted a highly strong direct negative effect (-1.2096) on yield. It is concluded that a direct selection based on monopodial branch length and sympo-boll distance, and staple length is effective, whereas, monopodial branch length, and sympodial branch length are good selection indicators via bolls per plant for yield improvement in cotton.
Implementation of an electronic patient-reported measure of barriers to antiretroviral therapy adherence with the Opal patient portal: Protocol for a mixed method type 3 hybrid pilot study at a large Montreal HIV clinic
Authors: Engler Kim , Vicente Serge , Ma Yuanchao , Hijal Tarek , Cox Joseph , Ahmed Sara , Klein Marina , Achiche Sofiane , Pant Pai Nitika , de Pokomandy Alexandra , Lacombe Karine , Lebouché Bertrand
Published: December 2021

Background

Adherence to antiretroviral therapy (ART) remains problematic. Regular monitoring of its barriers is clinically recommended, however, patient-provider communication around adherence is often inadequate. Our team thus decided to develop a new electronically administered patient-reported outcome measure (PROM) of barriers to ART adherence (the I-Score) to systematically capture this data for physician consideration in routine HIV care. To prepare for a controlled definitive trial to test the I-Score intervention, a pilot study was designed. Its primary objectives are to evaluate patient and physician perceptions of the I-Score intervention and its implementation strategy.

Methods

This one-arm, 6-month study will adopt a mixed method type 3 implementation-effectiveness hybrid design and be conducted at the Chronic Viral Illness Service of the McGill University Health Centre (Montreal, Canada). Four HIV physicians and 32 of their HIV patients with known or suspected adherence problems will participate. The intervention will involve having patients complete the I-Score through a smartphone application (Opal), before meeting with their physician. Both patients and physicians will have access to the I-Score results, for consideration during the clinic visits at Times 1, 2 (3 months), and 3 (6 months). The implementation strategy will focus on stakeholder involvement, education, and training; promoting the intervention’s adaptability; and hiring an Application Manager to facilitate implementation. Implementation, patient, and service outcomes will be collected (Times 1-2-3). The primary outcome is the intervention’s acceptability to patients and physicians. Qualitative data obtained, in part, through physician focus groups (Times 2–3) and patient interviews (Times 2–3) will help evaluate the implementation strategy and inform any methodological adaptations.

Discussion

This study will help plan a definitive trial to test the efficacy of the I-Score intervention. It will generate needed data on electronic PROM interventions in routine HIV care that will help improve understanding of conditions for their successful implementation.

Clinical trial registration

ClinicalTrials.gov identifier: NCT04702412; https://clinicaltrials.gov/.
Active pro-vaccine and anti-vaccine groups: Their group identities and attitudes toward science
Authors: Maciuszek Józef , Polak Mateusz , Stasiuk Katarzyna , Doliński Dariusz
Published: December 2021

Vaccine rejection is a problem severely impacting the global society, especially considering the COVID-19 outbreak. The need to understand the psychological mechanisms underlying the active involvement of the pro-vaccine and anti-vaccine movements is therefore very important both from a theoretical and practical perspective. This paper investigates the group identities of people with positive and negative attitudes towards vaccination, and their attitudes toward general science. A targeted sample study of 192 pro-vaccine and 156 anti-vaccine group members showed that the group identity of pro-vaccine individuals is higher than of anti-vaccine individuals. and that both pro-vaccine and anti-vaccine individuals had a positive attitude toward science. Results are discussed in context of the heterogeneity of motivations causing vaccine rejection and the relation between active involvement in online discussion and group identity.
Identification of hub genes and construction of an mRNA-miRNA-lncRNA network of gastric carcinoma using integrated bioinformatics analysis
Authors: Wei Gang , Dong Youhong , He Zhongshi , Qiu Hu , Wu Yong , Chen Yongshun
Published: December 2021

Background

Gastric carcinoma (GC) is one of the most common cancer globally. Despite its worldwide decline in incidence and mortality over the past decades, gastric cancer still has a poor prognosis. However, the key regulators driving this process and their exact mechanisms have not been thoroughly studied. This study aimed to identify hub genes to improve the prognostic prediction of GC and construct a messenger RNA-microRNA-long non-coding RNA(mRNA-miRNA-lncRNA) regulatory network.

Methods

The GSE66229 dataset, from the Gene Expression Omnibus (GEO) database, and The Cancer Genome Atlas (TCGA) database were used for the bioinformatic analysis. Differential gene expression analysis methods and Weighted Gene Co-expression Network Analysis (WGCNA) were used to identify a common set of differentially co-expressed genes in GC. The genes were validated using samples from TCGA database and further validation using the online tools GEPIA database and Kaplan-Meier(KM) plotter database. Gene set enrichment analysis(GSEA) was used to identify hub genes related to signaling pathways in GC. The RNAInter database and Cytoscape software were used to construct an mRNA-miRNA-lncRNA network.

Results

A total of 12 genes were identified as the common set of differentially co-expressed genes in GC. After verification of these genes, 3 hub genes, namely CTHRC1, FNDC1, and INHBA, were found to be upregulated in tumor and associated with poor GC patient survival. In addition, an mRNA-miRNA-lncRNA regulatory network was established, which included 12 lncRNAs, 5 miRNAs, and the 3 hub genes.

Conclusions

In summary, the identification of these hub genes and the establishment of the mRNA-miRNA-lncRNA regulatory network provide new insights into the underlying mechanisms of gastric carcinogenesis. In addition, the identified hub genes, CTHRC1, FNDC1, and INHBA, may serve as novel prognostic biomarkers and therapeutic targets.
COVID-19 associated hospitalization in 571 patients with fibromyalgia—A population-based study
Authors: Amital Mor , Ben-Shabat Niv , Amital Howard , Buskila Dan , Cohen Arnon D. , Amital Daniela
Published: December 2021

Objective

To identify predicators of patients with fibromyalgia (FM) that are associated with a severe COVID-19 disease course.

Methods

We utilized the data base of the Clalit Health Services (CHS); the largest public organization in Israel, and extracted data concerning patients with FM. We matched two subjects without FM to each subject with FM by sex and age and geographic location. Baseline characteristics were evaluated by t-test for continuous variables and chi-square for categorical variables. Predictors of COVID-19 associated hospitalization were identified using univariable logistic regression model, significant variables were selected and analyzed by a multivariable logistic regression model.

Results

The initial cohort comprised 18,598 patients with FM and 36,985 matched controls. The mean age was 57.5± 14.5(SD), with a female dominance of 91%. Out of this cohort we extracted the study population, which included all patients contracted with COVID-19, and consisted of 571 patients with FM and 1008 controls. By multivariable analysis, the following variables were found to predict COVID-19 associated hospitalization in patients with FM: older age (OR, 1.25; CI, 1.13–1.39; p<0.001), male sex (OR, 2.63; CI, 1.18–5.88; p<0.05) and hypertension (OR, 1.75; CI, 1.04–2.95; p<0.05).

Conclusion

The current population-based study revealed that FM per se was not directly associated with COVID-19 hospitalization or related mortality. Yet classical risk factors endangering the general population were also relevant among patients with FM.
Comparison of the most likely low-emission electricity production systems in Estonia
Authors: Baird Zachariah Steven , Neshumayev Dmitri , Järvik Oliver , Powell Kody M.
Published: December 2021

To meet targets for reducing greenhouse gas emissions, many countries, including Estonia, must transition to low-emission electricity sources. Based on current circumstances, the most likely options in Estonia are renewables with energy storage, oil shale power plants with carbon capture and storage (CCS), or the combination of renewables and either oil shale or nuclear power plants. Here we compare these different scenarios to help determine which would be the most promising based on current information. For the comparison we performed simulations to assess how various systems meet the electricity demand in Estonia and at what cost. Based on our simulation results and literature data, combining wind turbines with thermal power plants would provide grid stability at a more affordable cost. Using nuclear power to compliment wind turbines would lead to an overall levelized cost of electricity (LCOE) in the range of 68 to 150 EUR/MWh (median of 103 EUR/MWh). Using oil shale power plants with CCS would give a cost between 91 and 163 EUR/MWh (median of 118 EUR/MWh). By comparison, using only renewables and energy storage would have an LCOE of 106 to 241 EUR/MWh (median of 153 EUR/MWh).
Embodied metaphor in communication about lived experiences of the COVID-19 pandemic in Wuhan, China
Authors: Deng Yu , Yang Jixue , Wan Wan
Published: December 2021

The study investigated how a group of 27 Wuhan citizens employed metaphors to communicate about their lived experiences of the Corona Virus Disease 2019 (COVID-19) pandemic through in-depth individual interviews. The analysis of metaphors reflected the different kinds of emotional states and psychological conditions of the research participants, focusing on their mental imagery of COVID-19, extreme emotional experiences, and symbolic behaviors under the pandemic. The results show that multiple metaphors were used to construe emotionally-complex, isolating experiences of the COVID-19 pandemic. Most metaphorical narratives were grounded in embodied sensorimotor experiences such as body parts, battling, hitting, weight, temperature, spatialization, motion, violence, light, and journeys. Embodied metaphors were manifested in both verbal expressions and nonlinguistic behaviors (e.g., patients’ repetitive behaviors). These results suggest that the bodily experiences of the pandemic, the environment, and the psychological factors combine to shape people’s metaphorical thinking processes.
CATEGORIES OF LITIGATION IN CASES OF PROTECTING THE ELECTORAL RIGHTS OF CITIZENS OF THE RUSSIAN FEDERATION
Authors: Akimova I.L. , Kovalenko A. S. , Anichkin E. S.
Published: December 2021

The article examines the main types of electoral disputes considered by Russian courts in recent years.Illustrated by examples of court disputes on appealing decisions of election commissions on registration orrefusal to register candidates for elections of deputies of legislative (representative) government bodies of the constituent entities of the Russian Federation and local government bodies, senior officials of the constituententities of the Russian Federation (heads of the supreme executive body of state power of the constituententity of the Russian Federation), appeal against the registration of candidates (electoral associations) inconnection with violations committed during the campaign, as well as violations during voting and theestablishment of the results and results of elections. Based on the analysis of the established judicial practice,some amendments to the electoral legislation have been proposed
THE DOCTRINE OF “REMOVING THE CORPORATE VEIL”: A COMPARATIVE LEGAL ANALYSIS OF THE LEGISLATION AND JUDICIAL PRACTICE OF RUSSIA AND SOME ASIAN COUNTRIES
Authors: Filippova T.A. , Litskas M.V.
Published: December 2021

In this article, the authors aimed to give a comparative legal analysis of the doctrine of “removing thecorporate veil” in the context of legislation and judicial practice of the Russian Federation and some Asiancountries (People’s Republic of China, Indian Republic). In the process of studying this problem, it wasconcluded that there are similar norms in foreign legislation with Russian ones on the prohibition of usingthe legal status of a company for the purpose of abuse of law, on the prohibition of affiliation, as well as adiscussion rule on the full joint and several liability of the sole founder of a limited liability company. Inaddition, the conclusion is made about the increasing use of this doctrine in the country of an atypical legalfamily for it — the People’s Republic of China. Based on the materials of the judicial practice of the Republicof India, an attempt has been made to classify this doctrine according to the criterion of the purpose of abuse:in the case of a limited approach, the responsibility of the controlling persons is assigned in the case of theinitially fictitious purpose of creating a legal entity, and in the case of an unlimited approach — for any unfairaction using the limited liability structure of the founder (participant) of the company for its debts.
THE PROCESS OF DIGITALIZATION IN ADMINISTRATIVE COMMISSIONS OF LOCAL GOVERNMENT
Authors: Kolpakova Y.I.
Published: December 2021

The article is devoted to the investigation of issues related to the introduction and implementationof digital technologies in administrative commissions of local government, through a comprehensivereview of the theoretical, legal foundations, as well as the practice of applying new technologies. Duringthe introduction of digitalization into the daily activities of public authorities, the investigation of newmanagement processes in specific areas, in particular, in organization process in administrative commissionsunder the administrative body of local government plays an important role. Based on the analysis oftheoretical investigation, legal acts regulation and practice some suggestions are being made, aimed toimproving the digitalization process in the organization of administrative commissions of local governmentin Barnaul.
DEVELOPMENT OF AN INTEGRATED SCREENER FOR UNDERNUTRITION WITHIN A COMPREHENSIVE GERIATRIC ASSESSMENT SYSTEM
Authors: Wright O.R.L. , Klein K. , Lakhan P. , Vivanti A.P. , Gray L.C.
Published: December 2021

Objective: To develop a screener for the presence of undernutrition in older adults in acute care utilizing items within a comprehensive geriatric assessment (CGA) instrument (the interRAI Acute Care). Design: Prospective cohort study and retrospective medical record review of nutritional assessment data. Setting: Acute care tertiary teaching hospital in Brisbane, Australia. Participants: Five hundred fifty-seven general medical patients aged 70 and older admitted to the hospital. Measurements: Prevalence of geriatric syndromes at admission; measures of functional status (activities of daily living), cognition, behavioural symptoms, social support, community assistance services, health conditions, medications and other medical treatments, weight, body mass index (BMI), mode of nutritional intake; demographic variables and Subjective Global Assessment (SGA) of nutritional status. These measures were tested for their prediction of undernutrition using a logistic regression model and decision tree analysis. Results: The following variables were significant independent predictors of undernutrition on admission, after adjustment for age and gender: (i) feeling sad/depressed (OR: 3.494 [1.124-10.864]; p<0.05); (ii) short term memory recalling ability (OR: 3.325 [1.152-9.594]; p<0.05); (iii) weight loss of 5% or more in the last 30 days or 10% or more in the last 180 days (OR: 2.877 [0.983-8.416]; p=0.05); (iv) fatigue (OR: 3.494 [1.414-43.205]; p<0.05). Decision tree analysis revealed two models most predictive of undernutrition: (i) short term memory recalling ability and depression (AUC 72.8% [95% CI: 65%-80.6%]); (ii) short term memory recalling ability and recent weight loss (5% or more in the last 30 days or 10% or more in the last 180 days) (AUC: 74.8% [95% CI: 65.9% - 83.6%]). Conclusion: Several measures within the interRAI-AC may be used as part of a screener for undernutrition in acute hospital patients aged 70 years or older. The combination of short term memory recalling ability and percentage weight loss provides the most statistically robust screener for undernutrition within the interRAI-AC.