bluuebunny/crossref_metadata_2025 huggingface dataset:
Intrafamilial Occurrence of Hepatitis B Virus Infection in Family Contacts of HBsAg Positive Subject
Authors: Hassan Md Nazmoul , Hasan SM Ali , Jamal Mohammad Shah , Uddin Md Dalil , Faruque Abdullah Al , Akter Sabina , Hoque Mohammad Izazul
Published: August 2024

Background: Hepatitis B virus (HBV) infection is the global public health challenge. Family members of the HBV infected patients have a high risk of exposure to many blood-borne diseases including Hepatitis B and Hepatitis C viral infections. Of these Hepatitis B is not only the most transmissible infection, but also the only one (HBV) that is preventable by vaccination.
Objectives: To assess Occurrence of Hepatitis B Virus Infection in family contacts of HBsAg positive subject.
Methods: A six-month cross sectional study was carried out at the department of Medicine, Comilla Medical College. Ethical approval from the institutional review board was obtained to ensure patient privacy and confidentiality.
Results: Among 120 selected patients analysis of relatives with the infected patients revealed that most were son and daughters. In the study, out of 379 family members 316(83%) attended the study and 63 (17%) family members were unattended. Among attended family members 37 (11.7%) were known to be positive for HBV, 279 (88.3%) were found negative. Among the study subjects 68 (56.3%) were female and rest 52 (43.8%) were male. Female to male ratio was 1.28:1. Occupation of the study subjects where most were housewives (22.2%) and students (55%). Total 120 index cases, 15 (12.5%) cases were found positive family history for HBV, 90 (75%) were found negative and 15 (12.5%) were unaware of their all family members HBsAg status.
Conclusion: Family members staying same house of the HBV infected patients are at highest risk. Total 15(12.5%) index cases were found positive family for HBV infection. So they should take proper preventive measures.
J Com Med Col Teachers Asso Jan 2024; 28(1): 14-18
Serum Anti-SARS-CoV-2 IgG in Chronic Hepatitis B Virus Positive Patients
Authors: Mazumder Mohammad Mahadi Hasan , Begum Ifat Ara , Alam Mohammad Nurul , Hossain Mohammed Khaled Mosharraf , Gulshan Masrufa , Akter Nargis , Kaisar Sahidullah
Published: August 2024

Background: Advanced age and comorbidities such as diabetes mellitus, hypertension, chronic obstructive pulmonary disease or cardiovascular diseases are proven risk factors in COVID-19. In COVID-19, pre-existing liver illnesses could be a substantial risk factor for hospitalization and severity. Infection with the hepatitis B virus (HBV) is one of the most significant and common health disorders.
Objective: To estimate serum anti-SARS-CoV-2 IgG in chronic Hepatitis B virus positive patients.
Methodology: This cross-sectional analytical study was conducted in the Department of Biochemistry, Dhaka Medical College, Dhaka, during the period of January 2021 to December 2021. A total of 63 subjects were selected from Hepatology Department of DMCH and BSMMU as per selection criteria. Among them, 23 were chronic HBV positive patients (3 with COVID-19 and 20 without COVID-19) (group A) and the rest 40 were non HBV cases (20 with COVID-19 and 20 without COVID-19) (group B). Blood sample was collected for the measurement of anti-SARS-CoV-2 IgG. Biochemical analysis was performed by chemiluminescent microparticle immunoassay (CMIA) in the Department of Biochemistry, BSMMU, Dhaka.
Result: In this study, the mean age of group A was 47.26 ± 11.24 years and group B was 44.53 ± 10.17 years. Males were predominant in both the groups. In group A, male was 65.2% & female was 34.8% and in group B, male was 60% & female was 40%. The median value of serum anti-SARS-CoV-2 IgG level was 1110.70 in group A and 417.85 in group B (p>0.05). The study showed frequency of positivity of serum anti-SARS-CoV-2 IgG level in COVID-19 positive cases was 95.7% and in COVID-19 negative cases it was 90%. In this study, the median value of serum anti-SARS-CoV-2 IgG level significantly higher in COVID-19 positive (1063.20) than in COVID-19 negative (119.00) in non-HBV cases.
Conclusion: Serum anti-SARS-CoV-2 IgG level was non-significantly higher in chronic HBV positive patients than non-HBV patients.
J Com Med Col Teachers Asso Jan 2024; 28(1): 19-23
EXAMINING JOB STRESS AMONG INDONESIAN GEN Z EMPLOYEES USING JD-R MODEL
Authors: Hamdali Natalia Tamara , Liswandi Liswandi
Published: August 2024

Job stress is an issue for Indonesian Gen Z to thrive in the workplace. This study aimed to examine job stress using the JD-R model. Job insecurity, workload, and work environment were used as independent variables. The research was conducted using quantitative research. 207 responses from Indonesian Gen Z employees working in startup/digital companies in Jakarta was gathered using questionnaire and statistical analysis was performed using IBM SPSS 26. This research found that all variables have partial and simultaneous impact towards job stress. This seeks for companies to practice transparency and feedback with employees about the job future, workload, and work environment, as well as building a company culture that encourages employee growth.Â Keywords: gen Z, JD-R model, job insecurity, job stress, workload, work environment
Physical fitness and BMI in Men's Vocational Sailing School
Authors: Yusuf Jamaludin , Rahayu Setya , Handayani Oktia Woro Kasmini , Hidayah Taufiq
Published: August 2024

The maritime industry is known for its high physical demands. Students in maritime vocational programs, who will eventually work on ships, must have a good level of physical fitness to perform demanding tasks. Without adequate physical fitness, the risk of injury and fatigue increases, which can ultimately affect workplace safety and operational efficiency. This study aims to determine the Body Mass Index (BMI) and physical fitness levels of male students at SMK Baruna Pemalang. The research design uses a descriptive quantitative method to determine BMI and physical fitness levels. The test instruments are based on the Guidelines for the Nusantara Student Fitness Test from the Ministry of Youth and Sports of the Republic of Indonesia, with a validity of 0.471 and a reliability of 0.232. A sample of 61 male students was selected from a total population of 90 students. Data analysis in this study uses SPSS 26 to describe the BMI and physical fitness levels of the male students. The results indicate that the Body Mass Index of the students falls within the normal (healthy) range for a total of 35 students, while the average physical fitness level of the students is categorized as poor, with 46 students falling into this category. The findings of this study are expected to serve as baseline data for further research to improve the physical fitness levels of maritime vocational students.
HUBUNGAN KUANTITATIF STRUKTUR DAN AKTIVITAS SENYAWA TURUNAN BENZIMIDAZOL TERTAUTKAN 1,2,3-TRIAZOL SEBAGAI INHIBITOR ENZIM α-GLUKOSIDASE
Authors: Nurkholidah Intan , Puspa Widiyana Anita , Rina Bintari Yoni
Published: August 2024

ABSTRAK
Penemuan obat diabetes mellitus sedang banyak dilakukan akibat meningkatnya angka penderita diabetes mellitus. Peneliti menemukan penghambatan terhadap enzim α-glukosidase berperan penting dalam mencegah diabetes komplikasi dan mengontrol gula darah. Senyawa yang berpotensi menjadi inhibitor  enzim α-glukosidase yaitu turunan benzimidazol tertautkan 1,2,3-triazol. Hubungan Kuantitatif Struktur-Aktivitas (HKSA) menjadi metode yang digunakan untuk mengetahui hubungan parameter hidrofobik (LogP dan LogS), elektronik (Etotal dan EHOMO), dan sterik (MW dan Vw) dari senyawa turunan benzimidazol tertautkan 1,2,3-triazol dengan aktivitas sebagai inhibitor  enzim α-glukosidase. Parameter HKSA dan kriteria lipinski ditentukan menggunakan website online ADMET Lab 2.0 (https://admetmesh.scbdd.com/). Kriteria lipinski menunjukkan seluruh senyawa memenuhi syarat aturan sehingga senyawa turunan benzimidazol tertautkan 1,2,3-triazol dapat menjadi obat aktif jika diberikan per oral. Persamaan HKSA terbaik ditentukan dengan mempertimbangkan nilai r, nilai  r2, nilai p, nilai F, dan nilai S, sehingga persamaan yang paling terbaik yaitu -LogIC50 = -0.308 LogP -0.009 Etotal +0.196, dengan n= 15, r = 0.887; r2 = 0.787; F = 12.954; p = 0.004; S = 0.103. Persamaan menunjukkan adanya hubungan parameter Log P dan Etotal dengan aktivitasnya, semakin kecil Log P dan Etotal maka semakin besar aktivitas senyawa turunan benzimidazol tertautkan 1,2,3-triazol sebagai inhibitor enzim α-glukosidase.
Kata Kunci: Benzimidazol; Triazol; HKSA; Enzim α-glukosidase
GAMBARAN PERESEPAN OBAT GASTRITIS PADA PASIEN DOKTER SPESIALIS PENYAKIT DALAM DI SALAH SATU APOTEK DI KABUPATEN SUMEDANG
Authors: Ika Kurnia Sukmawati  , Raden Herni Kusriani  , Winda Sa’adah
Published: August 2024

GAMBARAN PERESEPAN OBAT GASTRITIS PADA PASIEN DOKTER SPESIALIS PENYAKIT DALAM DI SALAH SATU APOTEK SWASTA DI KABUPATEN SUMEDANG
 
ABSTRAK
Gastritis atau dikenal dengan penyakit maag adalah salah satu penyakit saluran  pencernaan  yang  sering  ditemukan  di  masyarakat  yaitu  suatu  kondisi peradangan yang terjadi pada mukosa lambung. Salah satu penyebabnya adalah berkurangnya  kualitas  hidup seperti  pola  makan  yang  kurang  baik,  merokok, konsumsi alkohol dan stress. Tujuan dari penelitian ini adalah untuk mengetahui gambaran persepan obat gastritis pada pasien dokter spesialis penyakit dalam di salah  satu  apotek  swasta  di  kabupaten  Sumedang  periode  bulan  Mei  2021. Metode :Penelitian  ini  merupakan  penelitian  observasional  dengan  metode  deskriptif menggunakan data retrosfektif berupa resep pasien yang terdapat obat gastritis. Populasi resep yang diperoleh yaitu 1.012, sedangkan sampel yang diperoleh dari penelitian  ini  yaitu  sebanyak  247  resep.  Hasil dan diskusi Proporsi  terbesar  berdasarkan jenis kelamin sejumlah 66% adalah perempuan, berdasarkan golongan obat sejumlah 60,98%  adalah  golongan  penghambat  pompa  proton,  berdasarkan  item  obat gastritis  sejumlah  53,38%  adalah  lansoprazol,  berdasarkan  kombinasi  obat sejumlah 71,31% adalah kombinasi lansoprazol dengan rebamipid. Kesesuaian dosis dengan literatur sejumlah 100%.
Kata   Kunci   :   Peresepan,   Obat   Gastritis,   Penghambat   Pompa   Proton, Lansoprazol
Pengaruh Variasi Suhu pada Proses Pirolisis Sampah Plastik LDPE sebagai Bahan Bakar Alternatif
Authors: A’la Ahmad fudloilul , Margianto  , Nur Robbi
Published: August 2024

Metode pirolisis merupakan beberapa teknik pengerjaan limbah saat dicerna. Tujuan percobaan ini adalah melakukan sampah plastik sebagai bahan bakar pirolisis. Jenis sampah plastik LDPE yang digunakan dalam penelitian ini adalah variabel, dan masing-masing percobaan dijalankan selama 15 menit pada suhu 100°C, 200°C, dan 300°C. Penelitian dengan variasi suhu sampel a menghasilkan minyak berwarna kuning dengan nilai kalor 10230kkl/kg nilai masa jenis 0,6 kg/m3 nilai viskositas0,40cp dan jumlah volume 20ml, sampel b menghasilkan minyak berwarnacoklat keruh dengan nilai kalor 9411,6kkl/kg nilai masa jenis 0,63 kg/m3 nilai viskositas0,58cp dan jumlah volume 38ml, sampel c menghasilakn minyak berwarna coklat jernih dengan nilai kalor 9002,4kkl/kg nilai masa jenis 0,65 kg/m3 nilai viskositas0,55cp dan jumlah volume 40ml. minyak terbaik dihasilkan pada suhu 100°C  yang memiliki nilai hampir sama dengan bahan bakar alternatif yaitu dengan nilai kalor 10230kkal/kg. Karena nilai kalornya, produk pirolisis dapat berfungsi sebagai pengganti bahan bakar konvensional
Formulasi dan Uji Stabilitas Fisik Sediaan Lotion Ekstrak Daun Pandan (Pandanus amaryllifolius) sebagai Repelen terhadap Nyamuk Aedes aegypti
Authors: Lailiyah Munifatul , Setyowati Ajeng
Published: August 2024

Lotion merupakan sediaan yang berbentuk emulsi cair terdiri dari fase dua fase yaitu fase minyak dan fase air yang distabilkan oleh emulgator, yang mengandung satu atau lebih bahan aktif di dalamnya. Lotion sebagai repelen yang beredar di masyarakat merupakan sintetis dari bahan kimia dan mengandung Diethyltoluamide (DEET). Oleh karena itu perlu di cari alternatif lain yang memiliki kandungan lebih aman di gunakan dan efek samping lebih sedikit namun memiliki efektivitas yang sama dengan DEET. Tanaman yang memiliki efek repelen salah satunya ialah tanaman daun pandan (Pandanus amaryllifolius). Daun pandan di ekstraksi menggunakan pelarut etanol 96% dengan metode maserasi, ekstrak yang didapat dibuat sediaan lotion dengan variasi konsentrasi yang berbeda yaitu 10 %, 20 %, 30 %. Sediaan lotion yang sudah dibuat dilakukan pengujian karakteristik meliputi organoleptis, homogenitas, pH, daya sebar, stabilitas dan efektivitas repelen. Hasil penelitian menunjukan bahwa lotion ekstrak daun pandan (Pandanus amaryllifolius). memenuhi parameter pengujin mutu fisik yaitu organoleptis, homogenitas, daya sebar, stabilitas dan uji efektivitas formulasi I sebesar 65,61%, formulasi II sebesar 88,33%, formulasi III sebesar 95,86%. Kesimpulan dari penelitian ini bahwa lotion ekstrak daun pandan (Pandanus amaryllifolius) stabil selama penyimpanan dan pada formulasi III 30% efektif digunakan sebagai repelen dikarenakan memiliki daya tolak lebih dari 90% dengan hasil nilai sebesar 95,86%.
Penentuan Toksisitas Ekstrak Kulit Naga Merah dan Kulit Apel Manalagi Metode Brine Shrimp Lethality Test
Authors: Andika Venny Kurnia , Ani Riani Hasana  , Yushinta Elsa Valina
Published: August 2024

Sebanyak 30-35% dari bagian buah merupakan kulit buah yang seringkali terbuang dan belum dimanfaatkan secara maksimal, padahal mengandung senyawa yang sifatnya berkhasiat bagi kesehatan. Buah naga merah dan apel manalagi merupakan buah-buahan yang rutin dikonsumsi masyarakat untuk kesehatan karena mengandung antioksidan yang tinggi. Kulit buah naga merah kaya akan antosianin yaitu pigmen merah alami yang memiliki kemampuan sebagai antioksidan, sedangkan kulit buah apel tinggi akan flavonoid yang menunjukkan tingginya aktivitas antioksidan. Saat ini telah banyak minuman kesehatan yang memanfaatkan bagian dari tanaman maupun buah untuk dijadikan sebagai terapi kesehatan sehingga perlu dilakukan pengujian yang bertujuan untuk menentukan khasiat serta keamanan produk. Metode yang dapat dilakukan adalah pengujian dengan metode Brine Shrimp Lethality Test (BSLT) untuk menentukan tingkat toksisitas suatu sampel yang diukur terhadap kematian Artemia salina. Pengujian dilakukan dengan mengukur toksisitas ekstrak kulit buah naga dan ekstrak kulit apel manalagi terhadap mortalitas Artemia salina dengan menentukan nilai LC50 dari masing-masing ekstrak sampel. Nilai LC50 ekstrak etanol 70% kulit buah naga merah yang diujikan pada larva Artemia salina sebesar 39,82479812 µg/mL dan nilai LC50 ekstrak etanol 70% kulit apel Manalagi yang diujikan larva Artemia salina sebesar 61,3205876 μg/mL. Hasil uji toksisitas menyatakan bahwa kedua sampel ekstrak tersebut termasuk dalam kategori toksik.
Pengaruh Edukasi Leaflet Terhadap Pengetahuan Penggunaan Antibiotik Siswa Kelas 10 SMA Negeri 1 Di Trawas
Authors: Andriani Mei Ika
Published: August 2024

Antibiotik umumnya digunakan untuk infeksi yang dikarenakan bakteri. Pemakaian antibiotik yang tidak selaras anjuran bisa membuat gagalnya terapi penyembuhan yang dilaksanakan. Tujuan dari penelitian ini yaitu untuk mengamati kaitan antar karakteristik responden pengetahuan antibiotik pada murid SMA Negeri 1 Trawas, dan untuk mengamati adanya perbandingan pengetahuan awal serta setelah dibagikan edukasi leaflet antibiotik pada murid SMA Negeri 1 Trawas. Pada penelitian ini menggunakan desain one grup pretest-post test research desain. Kemudian Intervensinya menggunakan Pemberian Edukasi melalui Leaflet. Hasil penelitian ini yaitu pada karakteristik responden usia diperoleh (p-value=1,529), yang artinya tidak ada hubungan karakteristik dengan tingkat pengetahuan, kemudian diperoleh hasil karakteristik responden dengan jenis kelamin yaitu (p-value=1,979) yang artinya tidak ada hubungan antara karakteristik dengan tingkat pengetahuan, kemudian diperoleh hasil sumber informasi (p-value=0,026) yang artinya terdapat hubungan karakteristik dengan tingkat pengetahuan. Dalam penelitian ini dilakukan uji Kolmogorov dari data pre post dan post test dan diperoleh hasil asym.sig 0,000 dimana data tidak terdistribusi normal. Kemudian dilakukan uji Wilcoxon dan diperoleh hasil (sig= 0,000 < 0,05) yang artinya terdapat perbedaan pengetahuan sebelum dan setelah edukasi. Kesimpulannya yaitu setelah diperoleh data bisa diambil simpulan bila yang terdapat hubungan karakteristik dengan tingkat pengetahuan yaitu sumber informasi. Kemudian yang didapatkan hasil sumber informasi yaitu dari teman atau keluarga yang paling tertinggi daripada hasil sumber informasi dari tenaga kesehatan atau google. Dan telah didapatkan hasil bahwa setelah mendapatkan edukasi didapatkan hasil pengetahuan dari responden lebih tinggi.
EFFECT OF MICROPLASTIC INTAKE ON INTESTINAL AND PANCREATIC CELL DAMAGE
Authors:   Department of Public Health, Widya Mandala Surabaya Catholic University, Wijono Steven , Parengkuan Irene Lingkan ,   Department of Anatomical Pathology, Widya Mandala Surabaya Catholic University, Morina Shella ,   Department of Forensic Medicine and Medicolegal, Widya Mandala Surabaya Catholic University, Supit Vincentius Diamantino ,   Gotong Royong Hospital Surabaya, Jaya David Karunia ,   Faculty of Medicine, Widya Mandala Surabaya Catholic University, Wicaksono Leonardo Suryanto ,   Faculty of Medicine, Widya Mandala Surabaya Catholic University, Iskandar Michael Christian ,   Faculty of Medicine, Widya Mandala Surabaya Catholic University
Published: August 2024

Introduction: Microplastics are plastic particles that result from the breakdown of larger plastic particles into smaller pieces and are found in natural environments such as oceans, beaches, and land. Microplastics harm the environment and affect human health. The main entrance of microplastics into the body is the digestive system, through the food and drinks we consume daily. Various investigations have shown that human feces samples contain microplastics that come from ingestion of contaminated food. If it continues, it can damage our body cells. Objective: This research aims to demonstrate that oral administration of microplastics can impair the function of the small intestine, large intestine, and pancreas in rattus of the strain Rattus norvegicus wistar. Method: This study is a quantitative analytic investigation employing an experimental methodology on experimental animals. In this work, the experimental animals were separated into six groups, including the control group and the treatment groups X1, X2, X3, X4, and X5; microscopic observations were conducted 90 days after the microplastics were administered. Results: The comparison of the control group with each exposure group to the small intestine revealed significant results in the Pearson correlation test in groups K with X2, X3, and X4 and the Mann-Whitney difference test in groups K with X2 and X4. Comparing the control group with each exposure group to the large intestine revealed no significant results in the Pearson correlation test and the Mann-Whitney difference test. Conclusion: The correlation test results between the control group and the complete exposure groups revealed significant outcomes in the small intestinal tissue but not in the large intestine and pancreas tissue.
The effect of the peer support intervention on internalized stigma among Thai patients with tuberculosis: A repeated measures design
Authors: Vibulchai Nisakorn , Dana Kamthorn , Sanchan Monruedee , Churari Charanya , Jadboonnak Bunjong , Sawangsri Wattana , Pothiporn Wansu Taweekanachote , Sutthicharoen Udomlak
Published: August 2024

Background: Internalized stigma among patients with tuberculosis (TB) significantly affects delayed diagnosis, increased disease transmission, and poor treatment outcomes. However, conclusive empirical evidence on psychosocial interventions to reduce internalized stigma among patients with TB in Thailand remains scarce.
Objective: This study aimed to examine the impact of a peer support intervention on reducing internalized stigma among patients with TB in Thailand.
Methods: A one-group within-subjects repeated-measure design was conducted in the Muang Maha Sarakham district, Thailand, from February 2023 to July 2023. The study included 26 participants who met specified criteria. Measurements were taken at baseline, three months, and six months following TB diagnosis and medication treatment. The peer support intervention comprised TB health education, psycho-educational sessions, self-management support, and home visits. The Internalized Stigma of Tuberculosis Scale Thai Version was used to measure internalized stigma. Statistical analyses included descriptive statistics and repeated measures ANOVA.
Results: Mean scores of total internalized stigma and its sub-dimensions (alienation, stereotype endorsement, discrimination experience, social withdrawal, and stigma resistance) differed significantly across the three-time points (p <0.001, p <0.001, p <0.001, p <0.001, p <0.001, p = 0.002, respectively). Furthermore, stigma resistance scores significantly increased from pre-intervention to three months (p = 0.005) and from pre-intervention to six months (p = 0.007). However, no significant increase was observed from three to six months (p = 0.079).
Conclusions: The study underlines the positive impact of peer support intervention in reducing internalized stigma among patients with TB in Thailand over time. The findings suggest that interventions focusing on peer support can potentially address internalized stigma, highlighting the importance of integrating these strategies into healthcare practices to enhance patient care and improve TB management outcomes.
Spoken Corrective Feedback in Offline Speaking Lessons at MNC University
Authors: Aiddin Malevna baha , Arianti Theresia
Published: August 2024

This study needs to be conducted because the teacher as a facilitator plays an important role in providing feedback and giving   additional information in the form of an explanation regarding errors in giving verbal motivation. This research aims to fulfill some objectives: 1) To investigate the kinds of corrective feedback that are most frequently utilized by the lecturer at MNC University 2) To analyze the reasons why the lecturer used this type of spoken corrective feedback in speaking classes at MNC University. This research used descriptive qualitative research approach. This study reveals that explicit with metalinguistic feedback was the most used type of feedback found; linearity between the feedback and studentsâ€™ needs and objectives is the main reason why the lecturer prefers this type of feedback.
STRATEGI PENCAPAIAN 20% RTH PUBLIK KOTA SUKABUMI
Authors: Yuwono Frendy , Mansyur Umar , Djakapermana Ruchyat Deni
Published: August 2024

Ruang Terbuka Hijau (RTH) adalah suatu kebutuhan bagi setiap kota di dunia, kehadirannya amat diperlukan untuk menjamin keberlanjutan pembangunan perkotaan. dan daya dukung lingkungan perkotaan. Di Indonesia kebutuhan untuk penyediaan RTH ini juga telah diatur melalui berbagai berbagai peraturan perundangan, yang pada pokoknya mengatur setiap wilayah perkotaan untuk menyediakan 30% lahannya bagi peruntukan RTH, yaitu 20% RTH publik dan 10% RTH Privat. RTH publik ini adalah RTH yang menjadi tugas pemerintah dalam pemenuhannya. Di Kota Sukabumi pemenuhan RTH publik ini masih sangat terbatas, tercatat secara eksisting baru mencapai 1,8% dari total luasan perkotaan. Masalah lahan selama ini menjadi faktor penghambat dari Kota Sukabumi dalam penyediaan RTH Publik, terbukti dengan minimnya peningkatan lahan untuk RTH Publik yang dimiliki oleh Kota Sukabumi, walaupun kebijakan mengenai kewajiban penyediaan RTH publik ini sudah cukup lama diterapkan. Kesulitan tersebut timbul karena sebagain besar dari lahan di perkotaan adalah milik perorangan sehingga tidak bisa dengan begitu saja dilakukan perubahan status lahan sebagai RTH publik. Apabila dijabarkan tujuan penelitian ini ada tiga, yaitu : 1). Mengatahui kondisi eksisting dan permasalahan lahan perencanaan 20% RTH publik kota Sukabumi, 2). Menganalisa potensi pengembangan 20% RTH publik Kota Sukabumi, 3). Menyusun strategi pemenuhan 20% RTH publik Kota Sukabumi. Penilitan ini dilakukan dengan model pendekatan spasial untuk mendapatkan kebutuhan lahan pengembangan RTH publik di Kota Sukabumi beserta statusnya, kemudian dilakukan perumusan strategi pemenuhan RTH publik melalui kegiatan Focus Group Discussion (FGD) dan pengolahan data dengan menggunakan metode delphi. Berdasarkan hasil penelitian ini, Kota Sukabumi, masih kekurangan 882,82 Ha lahan RTH publik atau 18,26% dari total luasan kota. Penilaian ini menghasilkan strategi diantaranya: 1) Pemanfaatan Hasil Prasarana Sarana Utilitas umum (PSU) Perumahan, 2) Pengenaan status ganda pada Lahan Pertanian Pangan Berkelanjutan (LP2B) sebagai Lahan RTH publik dan 3) Pemanfaatan lahan pemerintah non pertanian yang belum dimanfaatkan. Kata Kunci : 20% RTH publik, potensi lahan, status lahan, strategi
PEMANFAATAN BIOCHAR SEKAM DAN KOMPOS JERAMI PADI TERHADAP PERKECAMBAHAN BENIH CENDANA (Santalum album Linn.)
Authors: Aka Heku Firdaustian , Seran Wilhelmina , Riwu Kaho Norman P. L. B.
Published: August 2024

Sandalwood (Santalum album Linn.) is a forest wood-producing plant in East Nusa Tenggara (ENT) province that has high economic value and is an endemic species. Efforts to restored sandalwood plants in ENT have been carried out, such as development efforts by planting sandalwood from nurseries, as well as maintaining saplings that comes from natural spreading, but these efforts has not been successful enough. Giving rice husk biochar and rice straw compost in planting media can increased the availability of phosphorus (P), nitrogen (N), potassium (K), sulfur (S), calcium (Ca) and magnesium (Mg).The method used in this study is Complete Randomized Design (RAL) with a comparison of the composition of the planting media used (M0) Soil 100% Control 10 Kg, (M1) Soil 50% + 50% Biochar Rice Husk, (M2) Soil 50% + 50% Rice Straw Compost, (M3) Soil 25% + 50% Rice Husk Biochar + 25% Rice Straw Compost, (M4) Soil 25% + 25% Rice Husk Biochar + 50% Rice Straw Compost,  (M5) Soil 50% + 25% Rice Husk Biochar + 25% Rice Straw Compost.The results of this study showed that the germination percentage value was 38.67% in M4 treatment. M4 treatment with a ratio of soil planting media 25% + 25% Rice Husk Biochar + 50% Rice Straw Compost, provides the highest average increase and has a very significant effects on germination, germination rate index, and germination value.
KEANEKARAGAMAN VEGETASI ULTRABASA DI HUTAN LINDUNG NANGA-NANGA PAPALIA KOTA KENDARI
Authors: Basrudin Basrudin , Sali Mando La Ode Agus , Alfaridzhi Muh. Salman , Zainun Mariana
Published: August 2024

This research aimed to determine the ultra-basic vegetation diversity in the Nanga-Nanga Papalia Protected Forest, Kendari City, Southeast Sulawesi. The study was conducted in May to June 2023, covering an area of 42 hectares within the Nanga-Nanga Papalia Protected Forest. The sampling intensity was set at 5% over a study area of 2.1 hectares, resulting in 52 sampling plots arranged using the Line Transect method. The findings revealed that the ultra-basic vegetation diversity across all vegetation levels in the protected forest was classified as low, with values of 1.25 for trees, 1.22 for saplings, 1.27 for poles, and 1.13 for seedlings
ANALISIS MODEL SEIQR PENYEBARAN PENYAKIT CORONA VIRUS DISEASE 2019 (COVID-19)
Authors: Triana Devi , Sani Asrul , Kabil Djafar Muhammad , Arman  , Jufra  , Mukhsar
Published: August 2024

Penelitian ini mengembangkan model SEIQR untuk memodelkan penyebaran penyakit Covid-19 dengan menambahkan faktor penggunakan masker kesehatan dan karantina. Populasi dibagi menjadi enam subpopulasi yaitu subpopulasi rentan tanpa menggunakan masker kesehatan, subpopulasi rentan dengan menggunakan masker kesehatan, subpopulasi laten, subpopulasi terinfeksi, subpopulasi karantina, dan subpopulasi sembuh. Pembentukan model diawali dengan membuat diagram alur penyebaran virus covid-19 dengan model SEIQR. Dari model matematika yang dibentuk diperoleh dua titik kesetimbangan, yaitu kesetimbangan bebas penyakti dan kesetimbangan endemik. Setelah mendapatkan titik kesetimbangan, dilakukan analisis untuk mencari kestabilan model tersebut. Simulasi numerik titik kesetimbangan bebas penyakit dilakuakan untuk memberikan gambaran geometris terkait hasil yang telah dianalisis dengan nilai parameter yang diambil. Dalam simulasi model menghasilkan titik kesetimbangan bebas penyakit stabil pada kondisi  lebih kecil dari  dan titik kesetimbangan endemik stabil pada kondisi  lebih besar dari . Dari analisis model diperoleh bahwa upaya yang dapat dilakukan agar penyakit tidask mewabah yaitu mengurangi kontak langsung dengan individu terinfeksi, selalu menjaga kebersihan, melakukan karantina dan selalu menjaga jarak.
PENERAPAN METODE INTERPOLASI LAGRANGE DALAM MERAMALKAN JUMLAH PENDAPATAN PADA PERCETAKAN (STUDI KASUS: GEVIRA ADVERTISING)
Authors: Mansyur Nurul Nahdahfajriani , Arman  , La Gubu  , Somayasa Wayan , Aswani
Published: August 2024

Peramalan adalah memperkirakan sesuatu pada waktu yang akan datang berdasarkan data masa lampau. Interpolasi adalah metode menghasilkan titik-titik data baru dalam suatu jangkauan dari suatu set diskrit data-data yang diketahui. Tujuan penelitian ini yaitu untuk mengetahui model peramalan jumlah pendapatan dengan menggunakan Interpolasi Lagrange dan mengetahui hasil peramalan. Dalam penelitian ini digunakan metode Interpolasi Lagrange untuk memprediksi pada studi kasus nilai jumlah pendapatan percetakan Gevira Advertising. Berdasarkan jumlah pendapatan pada bulan Januari 2021 sampai November 2022 diperoleh model Interpolasi Lagrange derajat tujuh. Dari hasil analisis yang diperoleh, hasil peramalan pada bulan Desember 2022 hingga bulan April 2023 mengalami kenaikan dan penurunan jumlah pendapatan. Peramalan dengan metode Interpolasi Lagrange menghasilkan nilai Mean Absolute Percentage Error (MAPE) ≤10% sehingga akurasi peramalan masuk dalam kategori data sangat baik. Sehingga dapat dikatakan metode Interpolasi Lagrange sangat baik untuk meramalkan data jumlah pendapatan pada percetakan Gevira Advertising.
Product of Geometric Series on Prime Numbers is equal to Sum of Natural Numbers
Authors: Annamalai Chinnaraji
Published: August 2024

This paper presents a novel idea to compute the product of infinite geometric series on all prime numbers, which is equal to a series of natural numbers, that is, the sum of natural numbers up to infinite terms.
Application of Geometric Series and Maclaurin Series Relating to Taylor Series
Authors: Annamalai Chinnaraji
Published: August 2024

This paper presents a novel idea to compute the Maclaurin series and Taylor series and also provides application of the geometric series and the Maclaurin series.
Collatz Sequence Solution (2nd Way)
Authors: Muhammad Taha
Published: August 2024

Abstract of Collatz Sequence Solution (2nd Way) I discovered a fact in Collatz Sequence: S (n) = {a, b, c,…,w} ⇒ LS(n) = LS(a) = LS(b) = LS(c) = …. = LS (w) … (Fact1) n, a, b, c, w, r ∈ N_+, LS(n) = {4,2,1} when n ∈ {1,2,3,4,5, …, r-1} Let LS(r) = {4,2,1} when n ∈ Z = {1,2,3,4,5, …, r-1, r} Part a) If (r+1) ∈ (N_even), and I proved LS(r+1) = {4,2,1} ⇒ LS(n) = {4,2,1} for all even #s Part b) If (r+1) ∈ (N_odd), and I proved LS(r+1) = {4,2,1} by part a. Therefore LS(N) = {4,2,1} for all n ∈N.
Profession as Accounting for Non-Accounting Graduates
Authors: Putuhena Hempry , Pattinaja Elna M , Fauzan S M Rifhki , Kilay Trisye N
Published: August 2024

The challenges of finding work are getting harder every day, and accounting graduates face intriguing issues as a result of the intense competition for available positions and remarkable problems. From the perspective of non-accounting graduates, this study provides a deeper analysis of the phenomenon that takes place in the accounting industry. Numerous industries that use non-accounting graduates as accountants frequently experience this situation. Eleven non-accounting graduates from various firms will be interviewed as part of a qualitative approach to address this situation. This study reveals that their lack of prior accounting knowledge stems from their varied educational backgrounds, such as; their motivation to stay in their current position comes from both internal and external sources; their lack of prior computer knowledge and proficiency is a barrier; and, finally, their adaptation process is facilitated by co-workers and independent self-education through educational materials or courses. It is hoped that as this research advances, both qualitative and quantitative methods will be used to help understand this phenomenon comprehensively.
The Influence of the Implementation of Regional Government Information Systems and Internal Government Control Systems on the Quality of Financial Reporting
Authors: Naida Nasrun , Din Muhammad , Amir Andi Mattulada
Published: August 2024

This study aims to (1) explain the implementation of the Regional Government Information System (SIPD), the Government Internal Control System (SPIP), and the Quality of Financial Reports (KLK); (2) assess the impact of the implementation of SIPD on KLK; and (3) evaluate the effect of the implementation of SPIP on KLK. This study uses the Partial Least Squares (PLS) method in Structural Equation Modeling (SEM) with WarpPLS 8.0 software, involving 128 respondents. The research findings show that (1) the majority of Regional Government Work Units support the implementation of SIPD and SPIP to improve KLK; (2) the implementation of SIPD has a positive and significant effect on KLK; and (3) the implementation of SPIP also has a positive and significant effect on KLK.
Seas the opportunity: multi-criteria decision analysis to identify and prioritise blue carbon wetland restoration sites
Authors: Howie Alice H. , Rullens Vera , Thomas Anita , Kondylas Stella , Russell Sophie K. , Reeves Simon E. , Ament Judith M. , Castro Miguel , Detmar Sharie
Published: August 2024

Introduction

The emergence of voluntary carbon markets is creating new opportunities to sustainably finance Natural Climate Solution (NCS) projects. In Australia, the federal government recently enacted the Tidal Restoration of Blue Carbon Ecosystems Methodology Determination 2022 (Tidal Reconnection Method), whereby restoration activities that reintroduce tidal flows to allow the re-establishment of coastal wetland (blue carbon) ecosystems, through the removal or modification of a tidal restriction, can be used to gain and sell Australian carbon credit units. Australia has the highest net blue carbon wealth in the world, with 5%–11% of global carbon stocks, yet there is currently a lack of large-scale feasibility assessments and supporting methodologies to identify and prioritise sites with the greatest potential for NCS project implementation to help inform investment decisions.

Methods

In this study, we applied a spatial Multi-Criteria Decision Analysis (MCDA) to identify, map, and prioritise potential sites for blue carbon coastal wetland restoration in South Australia that meet criteria outlined in the Tidal Reconnection Method. This study compared information on 1) predicted flooding extent following tidal reconnection and under sea level rise (SLR; present-day, 2050 and 2,100); 2) project implementation complexity (e.g. who possesses land tenure); and 3) carbon sequestration potential through predicted area of vegetation change under the above SLR scenarios.

Results

Our results identified 64 sites of interest, of which 32 received an overall “high” prioritisation score of 3 or more out of 5. This equates to approximately 21,114 ha of high priority potential blue carbon restoration sites.

Discussion

The MCDA enables development of a portfolio of viable restoration projects through a rapid “desktop” prioritisation of sites of interest, which can then guide investment in further detailed cost/benefit feasibility assessments. This study demonstrates an adaptable MCDA approach to map potential NCS projects at meaningful spatial scales and in-line with carbon market-based opportunities.
New discrete fractional accumulation Grey Gompertz model for predicting carbon dioxide emissions
Authors: Jiang Jianming , Ban Yandong , Zhang Ming , Huang Zhongyong
Published: August 2024

Predicting carbon dioxide emissions is crucial for addressing climate change and achieving environmental sustainability. Accurate emission forecasts provide policymakers with a basis for evaluating the effectiveness of policies, facilitating the design and implementation of emission reduction strategies, and helping businesses adjust their operations to adapt to market changes. Various methods, such as statistical models, machine learning, and grey prediction models, have been widely used in carbon dioxide emission prediction. However, existing research often lacks comparative analysis with other forecasting techniques. This paper constructs a new Discrete Fractional Accumulation Grey Gompertz Model (DFAGGM(1,1) based on grey system theory and provides a detailed solution process. The Whale Optimization Algorithm (WOA) is used to find the hyperparameters in the model. By comparing it with five benchmark models, the effectiveness of DFAGGM(1,1) in predicting carbon dioxide emissions data for China and the United States is validated.
HLA-DR/DQ eplet mismatch predicts de novo donor-specific antibody development in multi-ethnic Southeast Asian kidney transplant recipients on different immunosuppression regimens
Authors: Wong Emmett Tsz Yeung , Pochinco Denise , Vathsala Anantharaman , Koh Wee Kun , Lim Amy , Sran Hersharan Kaur , D’Costa Matthew Ross , Chang Zi Yun , Nickerson Peter W. , Wiebe Chris
Published: August 2024

Eplet mismatch has been recognized as a more precise strategy for determining HLA compatibility by analyzing donor-recipient HLA differences at the molecular level. However, predicting post-transplant alloimmunity using single-molecule eplet mismatch categories has not been validated in Asian cohorts. We examined a cohort of Southeast Asian kidney transplant recipients (n = 234) to evaluate HLA-DR/DQ eplet mismatch as a predictor of de novo donor-specific antibody (dnDSA) development. HLA-DR/DQ single-molecule eplet mismatch was quantified using HLA Matchmaker, and we utilized previously published HLA-DR/DQ eplet mismatch thresholds to categorize recipients into alloimmune risk groups and evaluate their association with dnDSA development. Recognizing that the predominance of cyclosporine use (71%) may alter published eplet mismatch thresholds derived from a largely tacrolimus-based (87%) cohort, we evaluated cohort-specific thresholds for HLA-DR/DQ single-molecule eplet mismatch categories. Recipient ethnicities included Chinese (65%), Malays (17%), Indians (14%), and others (4%). HLA-DR/DQ dnDSA developed in 29/234 (12%) recipients after a median follow-up of 5.4 years, including against isolated HLA-DR (n = 7), isolated HLA-DQ (n = 11), or both (n = 11). HLA-DR/DQ single-molecule eplet mismatch risk categories correlated with dnDSA-free survival (p = 0.001) with low-risk recipients having a dnDSA prevalence of 1% over 5 years. The cohort-specific alloimmune risk categories improved correlation with HLA-DR/DQ dnDSA-free survival and remained significant after adjusting for calcineurin inhibitor and anti-metabolite immunosuppression (p < 0.001). We validated the performance of single-molecule eplet mismatch categories as a prognostic biomarker for HLA-DR/DQ dnDSA development in a cohort of predominantly Asian kidney transplant recipients after adjusting for different immunosuppression regimens.
Radiomics based on diffusion tensor imaging and 3D T1-weighted MRI for essential tremor diagnosis
Authors: Xu Bintao , Tao Li , Gui Honge , Xiao Pan , Zhao Xiaole , Wang Hongyu , Chen Huiyue , Wang Hansheng , Lv Fajin , Luo Tianyou , Cheng Oumei , Luo Jing , Man Yun , Xiao Zheng , Fang Weidong
Published: August 2024

Background

Due to the absence of biomarkers, the misdiagnosis of essential tremor (ET) with other tremor diseases and enhanced physiologic tremor is very common in practice. Combined radiomics based on diffusion tensor imaging (DTI) and three-dimensional T1-weighted imaging (3D-T1) with machine learning (ML) give a most promising way to identify essential tremor (ET) at the individual level and further reveal the potential imaging biomarkers.

Methods

Radiomics features were extracted from 3D-T1 and DTI in 103 ET patients and 103 age-and sex-matched healthy controls (HCs). After data dimensionality reduction and feature selection, five classifiers, including the support vector machine (SVM), random forest (RF), logistic regression (LR), extreme gradient boosting (XGBoost) and multi-layer perceptron (MLP), were adopted to discriminate ET from HCs. The mean values of the area under the curve (mAUC) and accuracy were used to assess the model’s performance. Furthermore, a correlation analysis was conducted between the most discriminative features and clinical tremor characteristics.

Results

All classifiers achieved good classification performance (with mAUC at 0.987, 0.984, 0.984, 0.988 and 0.981 in the test set, respectively). The most powerful discriminative features mainly located in the cerebella-thalamo-cortical (CTC) and visual pathway. Furthermore, correlation analysis revealed that some radiomics features were significantly related to the clinical tremor characteristics in ET patients.

Conclusion

These results demonstrated that combining radiomics with ML algorithms could not only achieve high classification accuracy for identifying ET but also help us to reveal the potential brain microstructure pathogenesis in ET patients.
Physiologically based pharmacokinetic models for systemic disposition of protein therapeutics in rabbits
Authors: Jairam Ravi Kumar , Franz Maria , Hanke Nina , Kuepfer Lars
Published: August 2024

Physiologically based pharmacokinetic (PBPK) modelling is an important tool to predict drug disposition in the body. Rabbits play a pivotal role as a highly valued small animal model, particularly in the field of ocular therapeutics, where they serve as a crucial link between preclinical research and clinical applications. In this context, we have developed PBPK models designed specifically for rabbits, with a focus on accurately predicting the pharmacokinetic profiles of protein therapeutics following intravenous administration. Our goal was to comprehend the influence of key physiological factors on systemic disposition of antibodies and their functional derivatives. For the development of the systemic PBPK models, rabbit physiological factors such as gene expression, body weight, neonatal fragment crystallizable receptor (FcRn) binding, target binding, target concentrations, and target turnover rate were meticulously considered. Additionally, key protein parameters, encompassing hydrodynamic radius, binding kinetic constants (KD, koff), internal degradation of the protein-target complex, and renal clearance, were represented in the models. Our final rabbit models demonstrated a robust correlation between predicted and observed serum concentration-time profiles after single intravenous administration in rabbits, covering IgG, Fab, F(ab)2, Fc, and Fc fusion proteins from various publications. These pharmacokinetic simulations offer a promising platform for translating preclinical findings to clinical settings. The presented rabbit intravenous PBPK models lay an important foundation for more specific applications of protein therapeutics in ocular drug development.
Protective effects of insulin on dry eye syndrome via TLR4/NF-κB pathway: based on network pharmacology and in vitro experiments validation
Authors: Yuan Xiuxiu , Zhang Yu , Wang Siyi , Du Zhiyu
Published: August 2024

Dry eye syndrome (DES) is a multifactorial ocular surface disease and represents one of the most prevalent ophthalmic disorders. Insulin is an important metabolism-regulating hormone and a potential antioxidant with critical biological roles as anti-inflammatory and anti-apoptotic. However, its mechanism of action remains unknown. In this study, we used network pharmacology techniques and conducted cell experiments to investigate the protective effect of insulin on human corneal epithelial cells (HCECs). Eighty-seven common targets of insulin and DES were identified from the database. KEGG pathway enrichment analysis suggested that insulin may be crucial in regulating the toll-like receptor (TLR) signaling pathway by targeting key targets such as IL-6 and TNF. In cell experiments, insulin promoted HCECs proliferation, improved their ability to migrate, and inhibited apoptosis. Western blot and enzyme-linked immunosorbent assay (ELISA) also confirmed the upregulation of the expression of inflammatory factors such as IL-1β, IL-6, and proteins related to the TLR4/NF-κB signaling pathway. However, the expression of these proteins was inhibited by insulin administration. Our results preliminarily verified insulin may exert a protective role on HCECs under hyperosmotic condition, which offered a novel perspective for the clinical management of this condition.
Tirzepatide’s innovative applications in the management of type 2 diabetes and its future prospects in cardiovascular health
Authors: Yang Jingqi , Gu Yuncheng , Chen Huaigang , Wang Hong , Hong Lang , Li Bin , Yang Liu
Published: August 2024

Tirzepatide, a novel GLP-1/GIP dual receptor agonist, shows significant advantages in glycemic management and weight control. By summarizing the results of the SURMOUNT and SURPASS clinical trials, we evaluate the efficacy and safety of tirzepatide in reducing blood glucose and weight. These trials indicate that tirzepatide significantly lowers HbA1c levels (with a maximum reduction of 2.24%) and promotes weight loss (up to 11.2 kg) with good tolerability. However, there are still some challenges in its clinical application, including high treatment costs and gastrointestinal discomfort. Additionally, the safety and efficacy of tirzepatide in special populations, such as patients with renal impairment, require further investigation. Future large-scale clinical trials, such as SURPASS-CVOT and SUMMIT, are expected to further verify the long-term benefits of tirzepatide in cardiovascular health management, providing stronger evidence for its comprehensive treatment of diabetes and its complications.
Tongue and jaw movement assessed by 3D motion capture during gum chewing
Authors: Sato Rikako , Kodama Shohei , Okawa Jumpei , Murakami Kazuhiro , Ono Takahiro , Hori Kazuhiro
Published: August 2024

Introduction

The tongue plays an important role in mastication, swallowing, and articulation, but it cannot be directly observed because of its location inside the oral cavity. This study aimed to clarify detailed 3D tongue movements during chewing using electromagnetic articulography (EMA).

Materials and Methods

The participants were 10 healthy, young volunteers (average age 26.8 ± 2.1 years; 5 males, 5 females). Tongue and jaw movement during gum chewing was measured and recorded using EMA. Four EMA sensors were attached to the anterior, posterior, left, and right surfaces of the tongue, and one sensor was also attached to the mandibular left incisor. The tongue motion during the chewing cycle was spatially and sequentially analyzed based on the motion trajectories of the tongue and mandible.

Results and Discussion

The tongue moved downward and to the masticatory side in a manner similar to the movement of the jaw. The anterior tongue marker moved downward to a greater extent than the other tongue markers. However, the tongue moved forward as the jaw moved backward. The anterior marker reached the most anterior position during the jaw-opening phase and the posterior markers reached the most anterior position during the jaw-closing phase. Just before maximum jaw-opening, all markers on the tongue reached the bottom lowest position. During the jaw-closing phase, the tongue reached the dominant farthest position in the masticatory side. All the markers reached the most posterior position during the occlusal phase.

Conclusion

These findings demonstrate the sequence of tongue motion patterns during gum chewing.