bluuebunny/crossref_metadata_2025 huggingface dataset:
Color in the educational environment for older people: recent research review
Authors:   Smolensk State University, Griber Yulia A. , Selivanov Vladimir V. ,   Smolensk State University, Weber Ralf ,   Technical University of Dresden
Published: November 2020

The purpose of the article is to present an analysis of the studies existing in domestic and foreign science of the necessary age-related "correction" of the color of the educational environment for older people, carried out in respect of the fact that chromatic communication is not limited exclusively to biological reactions, but its structure, in addition to perceptual one, includes much more significant psychological mechanisms and semiotic levels. The selection of research sources was carried out through the RSCI, Google Scholar, Scopus, and Web of Science systems. In total, 63 full texts of articles published between 1999 and 2019 were analyzed. In the process of work, the methods of theoretical and comparative analysis, systematization and generalization of the material were used. The analysis made it possible to distinguish three groups of research. The first group includes works that present the physiological prerequisites for the necessary changes in the chromatic design of the educational space intended for older people. The second group of studies analyzes various aspects of the impact of the color of the educational environment on older people in a psychological connotation. The third group involves the socio-cultural aspects of the formation of the educational environment for older people and analyzes this phenomenon in terms of connection with the lifestyle, way of thinking, physical and emotional-intellectual activity, and social conditions of the aging person. The results of the study convince that color correction in an educational environment designed for older people can cause noticeable changes in the quality of learning at several levels at once – biological (increasing the availability of information and significantly reducing physiological barriers to perception), psychological (supporting and strengthening the processes of memorization and information processing, increasing the psychological comfort of the educational environment), and social (improving the quality of life of older people).
Designing a personalized educational model while working with digital technologies
Authors:   North Caucasus Federal University, Gerasimova Elena K. , Zorin Sergey L. ,   Vyatka State University, Kobeleva Galina A. ,   Institute for Educational Development of the Kirov Region, Mamaeva Ekaterina A. ,   Vyatka State University
Published: November 2020

The problem and the aim of the study. The transformation of the educational environment identified the following development priorities for the didactic system: support for lifelong learning; personal orientation and taking into consideration the individual students’ personality structure; use of digital technologies to provide training of the sought-after professionals of the future. The authors propose to implement these requirements with the means and capabilities of modern information technologies that maximally take into account the characteristics of personification. Research methods. Theoretical and methodological analysis and generalization of fundamental scientific works on the research problem, processing of test results, problem solving, student’s choice (digital technology, appropriate software, functionality, sequence of tasks) were applied. The pedagogical experiment was attended by 101 students (35% of girls and 65% of boys) of the Law Institute of Vyatka State University of Kirov, Russia. The Fisher's criterion (angular transformation) was used as a statistical processing method. Results. The essence of the concepts "personal educational trajectory", "personal educational route" has been clarified. The challenges associated with the digital educational environment and a focus on training of the required professionals of the future were taken into account. The problems of personalization of learning (awareness of choice, determination of characteristic factors of the educational model, gradation of the task system) are identified, the content of which is described from the standpoint of the formal scheme of information interaction. An example of designing a personalized educational model is presented by studying the technology of processing spreadsheets (a system of educational problems that guide the trajectory of cognitive performance). At the control stage of the experiment, statistically significant differences were revealed between the experimental and control groups in terms of the level of formation of digital skills and skills that are in demand in the information society (φcrit=1.64<φemp=2.492). Conclusion. Work with digital technologies offers the opportunity to take into account the orientation of the modern educational space towards personalization, the continuity of learning due to the implementation of the described formal scheme of information interaction between a teacher and a student in educational and cognitive activities; designing a differentiated system of tasks; supporting the student's informed choice; social and professional orientation of action.
Formation of mediation competence of participants in the educational space of the Krasnoyarsk Territory in the Siberian Federal University
Authors:   Siberian Federal University, Smolyaninova Olga G. , Korshunova Vera V. ,   Siberian Federal University, Andronnikova Olga O. ,   Novosibirsk State Pedagogical University
Published: November 2020

Introduction. The relevance of the study is due to the lack of trained teachers - heads of school mediation services and future mediators. Reducing the deficit is possible only through increasing the competence of teachers in the field of conflict resolution and the formation of the ability and readiness to use mediation practices aimed at creating a conflict-free educational environment and harmonizing interethnic relations in a multicultural educational space. The authors presented a component-wise model of the formation of mediated competence of participants in the educational process from among the heads of school mediation services and future mediators and tested it. Materials and methods. The study used methods of measuring the components of mediation competence: communicative, information-analytical, organizational and managerial, emotional. The study involved two groups: students of the professional retraining program “Mediation. Psychology of Conflict Management ”55 people (experimental group) and 60 people (control group), teachers who are not trained in mediation programs. Comparative analysis of groups was carried out using the U-Mann-Whitney test. Results. Analysis of the effectiveness of the formation of mediation competence showed significant differences (p <0.05) on a number of scales that affect the effectiveness of the formation of components of mediation competence. Significant changes (p <0.05) were revealed in terms of the parameters of the severity of communicative skills, which indicates the formation of a confident partner style of behavior. Changes in the components of emotional competence are significant: emotional awareness (p = 0, 002), emotion management (p = 0, 045), recognition of other people's emotions (p = 0.021). There is a significant difference in the formation of information and analytical competence (p <0.05), primarily in the parameter of motivation (p = 0.000) of using mediation practices to resolve conflicts. Conclusion. It was revealed that the formation of the mediation competence of participants in the educational space of the Krasnoyarsk Territory can go through professional retraining programs and will be effective when combining the efforts of the academic community and practicing mediators, professional mediator communities and the cooperation of resources of various Siberian universities.
Organizational and managerial solutions for online (distance) interaction in the educational process at the school
Authors:   Ural Federal University named after the first President of Russia B. N. Yeltsin, Diachkova Anna V. , Kulkova Larisa I. ,   Municipal Autonomous educational organization “Gymnasium 9”
Published: November 2020

Introduction. The digitalization of education in the context of a pandemic served as an important factor in the transformation of traditional forms of communication, transferring all the variety of interactions between participants in educational relations into a distance format. In a situation of variability and uncertainty, the problem of finding effective organizational and managerial solutions to fulfill the tasks facing the school with the use of modern distant technologies has become keener. Research methods. To identify organizational and managerial decisions, to assess their effectiveness, a set of methods was used: questioning of teachers based on the research of Heldt, Lorenz and Eickelmann; statistical methods in the analysis of personal data (mean, standard deviation), a method for comparing the design of distant interaction between educational institutions in Russia and Germany. Results. Organizational and managerial solutions have been identified that ensured effective communication in solving the problems of the gymnasium in a distant format; it was found that the effectiveness of remote work is provided by a set of management decisions aimed at providing different types of support – technical, pedagogical, organizational; substantiated that the development and adoption of a media concept, regulations, instructions, recommendations for the organization and implementation of digital communication, the creation of unified media channels in the interaction systems "students – teacher", "parent – teacher", "teacher – school administration", "parent – school administration”, the participation of teachers in advanced training programs in aggregate ensured the solution of a complex of problems in the context of an aggravated epidemiological situation and in order to preserve health; defined the forms of corporate digital dialogue: exchange of effective communication practices, a system of support and mutual assistance, mutual training.
Factors of development of the Russian additional professional education market
Authors:   Russian State Social University, Lobazova Оlga F.
Published: November 2020

The results of the activities of higher education institutions in the field of additional professional education do not always reach high rates, which affects the process of implementing the state policy of labor market modernization. The hypothesis of this study was based on the assumption of a complex of conditions, in which the offers in the additional professional education market are formed, and which can be considered as a group of related but not homogeneous factors. To form the empirical base of the study, the authors selectively collected open data posted on the official websites of educational organizations on the Internet, which were then statistically and meaningfully processed using the systemic method. As a result, it was found that offers in the market of additional professional education services are formed under the influence of a number of objective factors, which are designated in the study as “standard, progress, market and fashion” factors. The application of this model to the analysis of the actual state of the additional professional education market made it possible to formulate three principles of effective organization, abiding by which some educational organizations obtain benchmark results: fields-of-study differentiation, functions delegation, and price diversification. Thus, the study made it possible to identify the most effective directions of the organizational activities of universities in the field of additional professional education and to formulate a number of provisions of practical significance. The prospect of the study is a factor analysis of further changes in that part of the additional professional education market, which is made up of state higher education institutions.
Formation of professional competences among master degree students of pedagogical universities in the process of practice-oriented learning
Authors:   Voronezh State Pedagogical University, Chernysheva Elena I. , Dakhin Denis V. ,   Voronezh State Pedagogical University, Brekhova Alla V. ,   Voronezh State Pedagogical University
Published: November 2020

Introduction. The relevance of the study is due to the need to transform the system of practice-oriented education, to search for effective mechanisms for organizing the educational process aimed at forming the professional competencies of future teachers. The process of preparing master degree students of pedagogical universities for a professional activity must meet the requirements of modern society, the higher education system, the requirements of regulatory documents and professional standards. Materials and methods. The study involved 125 master degree students of the Voronezh State Pedagogical University majoring in “Pedagogical education”. Basic research methods include the analysis of teaching activities, the study and generalization of innovative teaching and management experience, a pedagogical experiment. Pearson’s chi-squared test (χ2) was used to establish statistically significant differences between the control and experimental groups. Research results. Within the framework of the study, a practice-oriented model of formation of professional competencies in master degree students of pedagogical universities and the conditions for its effective functioning was developed and implemented. During the study, criteria and indicators of formation of professional competences among master degree students were determined: motivational (the level of educational and professional motivation), cognitive (professional knowledge, information-communication indicator) and activity-based ones (professional skills, organization, independence), levels of formation of professional competences. The experiment showed that the level of formation of professional competences among master degree students in the experimental group is higher than that of the control group (χ2 = 6.45; p<0.05). Conclusion. The research results can be used in the process of practice-oriented teaching and the organization of educational and on-the-job training of master degree students at pedagogical universities, aimed at forming professional competencies of future teachers. Keywords: activity-based approach, competency-based approach, practice-oriented learning, professional competencies, innovative technologies, practice-oriented learning model
Forming readiness for communication in innovative engineering and scientific research activity among technical university students by means of a foreign language
Authors:   Moscow Polytechnic University, Volodina Elena V. , Volodina Inga V. ,   Institute of International Economic Relations
Published: November 2020

The relevance of the study is caused by the fact that readiness for foreign language communication in innovative engineering and scientific research activity is one of the major components of specialist’s readiness to create innovative products, processes, services and their commercialization. Forming the content of the discipline «Foreign language» (English) for professionally oriented foreign language teaching for students of different types of training at a technical university is becoming more relevant. Applied research in the field of linguistics was conducted and the terminology for innovative and scientific research activity was defined (the level of education – baccalaureate). The algorithm of selecting lexical minimum was used on the basis of checking the frequency of using lexical units. There were 21 people in the control group and 21 people in the experimental group in the research. Pearson criterion χ2 was used to evaluate statistical significance of differences between the groups. It was found that using the universal module «Innovation and types of research» led to significant growth of students' level of foreign language proficiency in the experimental group comparing with the one in the control group (χ2 = 6,17; p = 0,05). The universal module developed can be used for different types of training at a university. The research represents practical value for specialists who deal with developing content, technologies, services, effective management for professionally oriented teaching of the discipline «Foreign language» (English) (the level of education – baccalaureate) for both full-time and distance education and foreign language teachers.
Simulation learning technologies in modern dental education: analysis of students’ opinions
Authors:   Kursk State Medical University, Felker Elena V. , Yachmeneva Lilia A. ,   Kursk State Medical University, Baroyan Margarita A. ,   Kursk State Medical University, Zubkova Anna A. ,   Kursk State Medical University, Vinokur Alexander V. ,   Kursk State Medical University
Published: November 2020

Simulation training in medicine opens up new horizons for students’ practical training, advanced training of practicing physicians, as well as systems for assessing the formation of competencies. The Dentist Laboratory, in which dental students start learning already in the first year of study, is successfully functioning in the Training Simulation Center (TSC) of Kursk State Medical University (KSMU). To study the satisfaction of students with the effectiveness of using simulation training in the formation of practical skills, after passing the test during on-the-job training, a voluntary anonymous survey of 110 fourth-year students of the Faculty of Dentistry of Kursk State Medical University was conducted. The questionnaire included a question pool for approval of the argument, and the overwhelming majority of the surveyed students recognize the clear advantages of using simulation technologies at all stages of medical education. 84% of the respondents noted that the reality of sensations when modeling clinical situations in the phantom class of KSMU is close to a real hospital environment. The respondents identified the required number of trainings they needed to confidently master the basic practical skills, as well as highlighted the disadvantages of simulation training in comparison with actual clinical practice. Analyzing the data obtained and taking into account the students’ general desire to increase the total number of trainings, the schedule of classes in the simulation class of KSMU was corrected.
Climate Change and Agriculture in the Northeast: Teamwork, Responses, and Results
Authors: Tobin Daniel , Lane Erin , Hoover Ron
Published: November 2020

Not everyone may agree on the best adaptation practices all the time, but as opposed to rigid guidelines, a whole suite of options are being developed that will allow individuals to pick and choose
what best works for them. But being proactive in ways that have both an economic and environmental outlook will determine agriculture’s success in responding to changes in climate. With collaboration and cooperation, the northeast can meet the challenge to maintain and improve production. The biggest risk is not climate change itself; it is being passive as these changes occur.
Current Activities and Future Priorities of the Northeast U.S. to Address Climate Impacts in Agriculture
Authors: Thorn Kaila , Radhakrishna Rama , Tobin Dan , Chatrchyan Allison , Chan Joana , Allred Shorna
Published: November 2020

Findings from this study provide insight into the current activities and future priorities that land-grant university research and Extension personnel in the Northeast are conducting to address climate impacts
in agriculture. The respondents of this study represented research faculty, Extension specialists, and Extension educators from the 16 land-grant universities in the Northeastern U.S.
Farming the floodplain: New England river governance in a changing climate
Authors: Schattman Rachel
Published: November 2020

River governance is notoriously complex. Climate change will alter how people interact with rivers. Will current river governance structures serve us in the future? Or is it time to reconsider our current rules and regulations?
Drought Vulnerability Assessment to Inform Grazing Practices on Rangelands in Southeast Arizona and Southwest New Mexico’s Major Land Resource Area 41
Authors: Wyndham Amber , Elias Emile , Brown Joel R. , Wilson Michael A. , Rango Albert
Published: November 2020

Increased climate variability, including more frequent and intense drought, is projected for the southwestern region of the United States. Increased temperatures and reduced precipitation lower soil water availability, resulting in decreased plant productivity and altered species composition, which may affect forage quality and quantity. Reduced forage quality and increased heat stress attributable to warmer temperatures could lead to decreased livestock performance in this system, which is extensively used for livestock grazing. Mitigating the effects of increasing drought is critical to social and ecological stability in the region. Reduced stocking rates and/or a change in livestock breeds and/or grazing practices are general recommendations that could be implemented to cope with increased climatic stress. Ecological Sites (ESs) and their associated state-and-transition models (STMs) are tools to help land managers implement and evaluate responses to disturbances. The projected change in climate will vary depending upon geographic location. Vulnerability assessments and adaptation strategies are necessary at the local level to inform local management decisions and help to ameliorate the effects of climate change on rangelands. The USDA Southwest Climate Hub and the Natural Resources Conservation Service (NRCS) worked together to produce this drought vulnerability assessment at the Major Land Resource Area (MLRA) level: it is based on ESs/STMs that will help landowners and government agencies to identify and develop adaptation options for drought on rangelands. The assessment illustrates how site-specific information can be used to help minimize the effects of drought on rangelands and to support informed decision-making for selecting management adaptations within MLRA 41.
Recent Trends in Climate/Weather Impacts on Midwestern Fruit and Vegetable Production
Authors: Kistner-Thomas Erica
Published: November 2020

While the Midwest is famous for being the world’s leader in corn and soybean production, this region is also home to a variety of high value specialty crops. Specialty crops include fruits and vegetables, tree nuts, dried fruits, and nursery crops including floriculture.
Consider Weather Forecasts Beyond One Week
Authors: Lane Erin , Buda Anthony
Published: November 2020

As we plan our week's activities, we often turn to the seven day weather forecast. Could we plan even further into the future?
Potential Geographical Range & Abundance of the Invasive Brown Marmorted Stink Bug under Climate Change Scenarios
Authors: Kistner-Thomas Erica
Published: November 2020

Climate change is predicted to exacerbate agricultural losses from crop pests and pathogens by 1) expanding their geographic ranges, 2) reducing winter die-offs, and 3) increasing the number of generations produced per year. For example, numerous crop pests and pathogens have expanded their range northward since the 1960s due, in part, to warming annual temperatures.
Adaptation Workbook Case Study: Kettner Farm, Mulshoe, TX
Authors: Reisner Jodie
Published: November 2020

The Adaptation Resources for Agriculture Workbook was jointly developed by USDA Climate Hubs and NRCS to support producers, service providers, and educators to manage climate change. The workbook helps producers consider both short-term adaptive management actions (<5 yrs) and long-range strategic plans (5 to 20 yrs, subject to farm type). This workbook pro-motes adaptation through multiple resources including a “menu” of adaptation strategies/approaches and example tactics for cropping and forages, confined livestock, grazing, orchards and small fruit and vegetable production systems. Recent efforts by USDA Climate Hub NRCS Liaisons work to increase the number of examples, and have been documented as Case Studies. These Case Studies are of producers utilizing the 5-step process in the workbook to document their management choices to ameliorate climate change impacts to their operations.
Drought in the U.S. Caribbean: Impacts on Tropical Forest Ecosystems
Authors: Crausbay Shelley , Gould William , Fain Josh
Published: November 2020

This fact sheet is part of a series examining what we know about the impacts of drought on ecosystems
and agriculture in the U.S. Caribbean.
Ostrowski's Type Inequalities for the Complex Integral on Paths
Authors: Dragomır Sever
Published: November 2020

In this paper we extend the Ostrowski inequality to the integral with respect to arc-length by providing upper bounds for the quantity

|f(v)ℓ(γ)-∫_{γ}f(z)|dz||

under the assumptions that γ is a smooth path parametrized by z(t), t∈[a,b] with the length ℓ(γ), u=z(a), v=z(x) with x∈(a,b) and w=z(b) while f is holomorphic in G, an open domain and γ⊂G. An application for circular paths is also given.

Several applications for circular paths and for some special functions of interest such as the exponential functions are also provided.
Шляхи вирішення проблем управління вантажопотоками в транспортних системах України
Authors: Прокудін Г.С. , Чупайленко О.А. , Дудник О.С. , Прокудін О.Г.
Published: November 2020

Збільшення ролі вантажних перевезень в обслуговуванні міжнародного вантажообігу, підсилення ролі експедиційної діяльності у формуванні попиту та пропозиції докорінно змінило концепції транспортного ринку. З іншої сторони, створення єдиної міжнародної транспортно-логістичної системи та географічне положення транспортного простору України в якості міжнародних транспортних коридорів вимагає окремого аналізу управління роботи транспортних вузлів і митних систем, забезпечення координації та взаємодії транспорту і митних пунктів пропуску, результативності досягнень науково-технічного прогресу на транспорті і митній справі. Процес формування міжнародної системи перевезень не завершився. Більш того, остаточне рішення ряду проблем міжнародних перевезень та освоєння нових технологій знайде своє втілення лише на межі першої чверті XXI сторіччя.
Теоретичні аспекти визначення залишкового ресурсу вагона-цистерни для небезпечних вантажів
Authors: Кельріх М.Б. , Фомін О.В. , Прокопенко П.М. , Сова С.С.
Published: November 2020

В статті виконаний детальний аналіз сучасного стану експлуатаційного парку залізничних вагонів-цистерн для транспортування небезпечних вантажів залізницями України. Аналіз показує, що залізничні вагони-цистерни для перевезення небезпечних вантажі значною мірою вичерпали свій ресурс. Технічний стан вагонів-цистерн після проведення планових видів ремонту свідчить про те, що більша їх частина знаходиться в справному технічному стані. З метою продовження безпечної експлуатації з терміном служби,що вичерпаний виконується технічне діагностування і випробування вагонів-цистерн.
Ліпосоми per se: фармакотерапевтичний статус
Authors: Григор’єва Г. С. , Краснопольський Ю. М.
Published: November 2020

Сучасне переважне сприйняття нанорозмірних ліпідних артефактів – ліпосом як систем транспорту ліків (DDS), що ґрунтується на здатності до універсальної інкорпорації активних фармацевтичних інгредієнтів, сформувалось у процесі створення та клінічного застосування в світі понад 50інноваційних ліпосомальних препаратів для лікування онкологічних, інфекційних, запальних та інших важких захворювань. Серед них – створені в Україні оригінальні засоби Ліпін, Ліподокс, Ліолів і Ліпофлавон.Поряд із визнанням ролі ліпосом як провайдера активних фармацевтичних інгредієнтів переконливо підтверджена концепція фармакотерапевтичної самодостатності ліпосом per se («порожніх» ліпосом), що вперше запропонована академіком НАМНУ О. В. Стефановим. Відповідно до варіабельності фосфоліпідного складу для порожніх ліпосом встановлені антимікробні, противірусні, протизапальні, імуномодулюючі та інші прояви фармакологічної активності.До найважливіших доказів ефективності та широти спектра клінічного застосування порожніх ліпосом належить лікарський засіб «Ліпін». Наведено показову експериментальну й клінічну інформацію щодо фармакотерапевтичного застосування Ліпіну в пульмонології, кардіології, нефрології,гінекології та акушерстві. Зазначено можливість клінічного позиціонування Ліпіну для стоматології, дерматології та радіаційної медицини. Ефективність і безпечність системного застосування Ліпіну в різних клінічних галузях відображають універсальність механізму дії порожніх фосфоліпідних ліпосом з акцентом на антиоксидантну, антигіпоксичну, мембранопротекторну, імуномодулюючу дію, просурфактантну активність.Звернуто увагу на потенціал ліпосом per se для реалізації стратегії персоналізованої медицини та клінічні переваги алгоритму сумісного використання порожніх ліпосом із DDS з можливістю оптимізації клінічного ефекту за цілеспрямованої диференціації фосфоліпідного складу ліпосомальних партнерів.
Better Living Environment Today, More Adaptable Tomorrow?
Authors: Saarimaa Sini , Pelsmakers Sofie
Published: November 2020

In Finland, maximising urban land value has often resulted in urban housing with increased efficiency. This study highlights how increased building efficiency can lead to reduced living environment quality, manifesting in for example deep plan plans with limited opportunities for dwellers to adapt spaces to meet their changing needs over time. Within the Finnish urban housing context, this study evaluates the adaptation potential of two case study apartment buildings, with seven apartments studied in more detail. These cases represent a broader set of housing cases finished in 2019 or planned to be constructed in 2020–2022 in Finland's largest urban areas. Illustrated by comparative building and apartment plans, the findings indicate that the selected cases generally lack much capacity to accommodate change, but this can be improved with fairly simple spatial modifications with the same apartment number and size. It was also highlighted that in some cases there may be broader implications for the land use, and the city plan. The implications of the findings draw out a discussion about the inter-relationship between housing adaptability, dwelling quality and apartment type, building typology and urban housing block design at the city plan level.
Cadmium Chloride Toxicity Revisited: Effect on Certain Andrological, Endocrinological and Biochemical Parameters of Adult Male Rabbits
Authors: SAJJAD S. , MALIK H. , FAROOQ U. , RASHID F. , NASIM H. , TARIQ S. , REHMAN S.
Published: November 2020

The present study was devised to assess the effects of cadmium chloride (CdCl2) administration on certain andrological, endocrinological and biochemical alterations in adult male rabbits (n=24). The animals were assigned to control (n=8) and experimental (n=16) group. Experimental group was orally administered with 1.5 mg/kg body weight of CdCl2. The trials were carried out for a total of 5 weeks and blood sampling was carried out on weekly basis. A gradual decrease was noticed for body weight in the experimental group from week 1 to 5, being significantly lower in week 4 and 5 (P<0.05). A similar decremented trend was noticed for serum testosterone level being significantly lower in experimental group in week 4 and 5 (P<0.001). Significantly lower values were noticed for prolactin in experimental group in week 4 and 5 (P<0.05), than in the control. On the contrary, serum cortisol level showed a gradual increase in experimental group, from week 1 to 5, being significantly higher in week 4 and 5 (P<0.05). Regarding the biochemical attributes, all the parameters under study revealed a gradually ascending trend. Statistical significance was, however, achieved in varying weeks and at varying levels. The total protein and albumin were significantly higher in week 4 and 5 (P<0.01); alanine aminotransferase in week 2 (P<0.01), 3 (P<0.001), 4 (P<0.01) and 5 (P<0.001); aspartate aminotransferase in week 1, 2, 3, 4 and 5 (P<0.01); and alkaline phosphatase in week 1, 2 (P<0.01), 3, 4 and 5 (P<0.0001), respectively. Overall mortality rate in experimental group was 68.75 (11/16). In a nutshell, Cd exposure results in adverse effects on all physiological parameters of body and may lead to lethal consequences.
Determination of Homocysteine in Cerebrospinal Fluid As an Indicator for Surgery Treatment in Patients With Hydrocephalus
Authors: SOSVOROVÁ L. , BEŠŤÁK J. , BIČÍKOVÁ M. , MOHAPL M. , HILL M. , KUBÁTOVÁ J. , HAMPL R.
Published: November 2020

Increased homocysteine levels in serum are typical features of neurodegenerative brain diseases including hydrocephalus. The most frequent therapeutic approach consists of the insertion of a shunt, connecting the brain ventricles to an alternative drainage site. To decide whether the patient should undergo this, the lumbar drainage test is usually carried out to distinguish patients who can benefit from the shunt insertion. In searching for other potential biochemical markers for shunt indication we determined homocysteine levels in CSF during the lumbar drainage test. Homocysteine in CSF was measured during the 5-day lumbar drainage test in 27 patients with normal-pressure hydrocephalus (NPH) and in 25 patients with excluded hydrocephalus. A novelized gas chromatography method with flame ionization detection (GC-FID) was developed and evaluated. During the first two days of lumbar drainage, the levels of CSF homocysteine in NPH patients were significantly higher compared to the controls, while on the fifth day, the homocysteine levels in patients with hydrocephalus reached the level of controls. Determination of CSF homocysteine in patients with confirmed or suspected hydrocephalus may serve as an independent marker for deciding on their further treatment strategy.
Important Role of Autophagy in Regulation of Metabolic Processes in Health, Disease and Aging
Authors: PAPÁČKOVÁ Z. , CAHOVÁ M.
Published: November 2020

Autophagy is the basic catabolic mechanism that involves degradation of dysfunctional cellular components through the action of lysosome as well as supplying energy and compounds for the synthesis of essential biomacromolecules. This process enables cells to survive stress from the external environment like nutrient deprivation. Autophagy is important in the breakdown of proteins, carbohydrates and lipids as well. Furthermore, recent studies have shown that autophagy is critical in wide range of normal human physiological processes, and defective autophagy is associated with diverse diseases, including lysosomal storage disease, myopathies, neurodegeneration and various metabolic disorders. This review summarizes the most up-to-date findings on what role autophagy plays in metabolism.
Acute Liver Failure Induced by Thioacetamide: Selection of Optimal Dosage in Wistar and Lewis Rats
Authors: KOBLIHOVÁ E. , MRÁZOVÁ I. , VERNEROVÁ Z. , RYSKA M.
Published: November 2020

Acute liver failure (ALF) is a clinical condition with very high mortality rate. Its pathophysiological background is still poorly understood, which necessitates a search for optimal experimental ALF models with features resembling those of the human disorder. Taking into consideration reproducibility of induction of ALF, adequate animal size, cost of animals, the required time gap between insult and death of animals (“therapeutic window”), potential risk to investigator and other aspects, administration of thioacetamide (TAA) in rats is currently most recommended. However, the fundamental details of this ALF model have not yet been evaluated. This prompted us to investigate, first, the course of ALF as induced by intraperitoneal TAA at doses increasing from 175 to 700 mg/kg BW per day. The animals’ survival rate, plasma alanine and aspartate aminotransferase activities, and bilirubin and ammonia levels were determined over the follow-up period. Second, we examined whether Wistar and Lewis rats exhibit any differences in the course of ALF induced by different TAA doses. We found that the optimal dose for ALF induction in rats is 350 mg.kg-1 i.p., given as a single injection. Wistar rats proved more susceptible to the development of TAA-induced ALF compared with Lewis rats. Collectively, our present findings provide a sound methodological background for experimental studies aimed at evaluation of pathophysiology and development of new approaches in the therapy of ALF.
Changes in FGF21 Serum Concentrations and Liver mRNA Expression in an Experimental Model of Complete Lipodystrophy and Insulin-Resistant Diabetes
Authors: ŠPOLCOVÁ A. , HOLUBOVÁ M. , MIKULÁŠKOVÁ B. , NAGELOVÁ V. , ŠTOFKOVÁ A. , LACINOVÁ Z. , JURČOVIČOVÁ J. , HALUZÍK M. , MALETÍNSKÁ L. , ŽELEZNÁ B.
Published: November 2020

Patients with obesity and type 2 diabetes often display high levels of the anti-diabetic factor fibroblast growth factor-21 (FGF21), suggesting that the overproduction of FGF21 may result from increased adiposity in an attempt by white adipose tissue (WAT) to counteract insulin resistance. However, the production of FGF21 diabetes in the absence of WAT has not been examined. In this study, we investigated the effects of lipodystrophy in A-ZIP F-1 mice on FGF21 production in relation to diabetes. A-ZIP F-1 mice displayed high FGF21 plasma levels resulting from enhanced FGF21 mRNA expression in the liver. Concomitant enhancement of FGF21 receptor (FGFR1) and glucose transporter 1 (GLUT-1) mRNA expression was observed in the muscles of A-ZIP F-1 mice. Furthermore, the activation of hypothalamic NPY and AgRP mRNA expression positively correlated with plasma levels of FGF21 but not active ghrelin. Our study demonstrates that an increased FGF21 plasma level in lipodystrophic A-ZIP F-1 mice results mainly from up-regulated liver production but does not suffice to overcome the lipodystrophy-induced severe type 2-diabetes and insulin resistance in the liver linked to the augmented liver fat deposition.
ADATABLE INDUSTRIAL 4.0 : AN IMPROVEMENT DETECTED OBSOLETE BUSHING CONDITION ON RUBBER CURING MACHINE INDUSTRY
Authors: Purwanto Agus , Sofyan Edi
Published: November 2020

Bushing is a part of rubber curing machine that have function as cushion pin joint , generally make from a bronze material. Pin joint have a function to connected with 1 paired linkage arm with rotated crank gear of each via pin joint to get closing force at rubber curing machine when mould closed. When bushing condition at pin joint on rubber curing machine was not good caused by friction. It will make closing force linkage arm left and right ( 1 paired ) on rubber curing machine unbalanced. So it will make closing force to force closed rubber mould undistributed evenly, so it caused mould rubber closed with gap. This condition will make defect rubber product open mould after cured finished. In this case is important to find new methode detection and monitored bushing condition. This research was done by measured vibration around pin joint at linkage arm by taking data of sound and acceleration on the real object research and used 2D software simulator to measured bushing condition good or not. Acceleration measurement was done by measured at axis Y and Z by used accelerometer sensor, and accelero sensor on cell phone via sains journal android application. And collected the data stress value on linkage arm by used nidle dial gauge millimeter scale. By simulation software are measured acceleration at axis X and Y with good bushing condition or vise versa.The actual data that was collected : acceleration, sound vibration and stress value and simulated data by software to be compare the amplitude and choose the biggest amplitude as new methode measurement of vibration to detect and monitor bushing condition.From the result data, detection of vibration around pin joint by acceleration value by used accelerometer sensor measured at axis Y and Z more prefer with the other measurement methode.
PERSEPSI ORANG TUA DALAM PEMILIHAN ACARA TELEVISI UNTUK PERKEMBANGAN MORAL ANAK USIA SEKOLAH DASAR DI DUSUN SIMPANG PAWUO DESA PULAU TERAP KECAMATAN KUOK
Authors: Hazlina Yona
Published: November 2020

This study aims to determine the perception of parents in choosing television programs for the moral development of elementary school children in Kuok, Simpang pawuo hamlet, terap island village RT 04 RW 02. This research method uses descriptive quantitative research, the research subjects are parents of elementary school students who reside lives in Simpang pawuo hamlet RT 02 RW 04. The data collection techniques used were observation, interviews, questionnaires, documentation. The data analysis technique in this study used descriptive quantitative data analysis techniques. By calculating the percentage of anget yields that were carried out in the Simpnag Pawuo hamlet, Terap Island, Kuok, Kampar, Riua. the percentage of the questionnaire performance on each indicator is more than 70%. On the result of the percentage indicator. With the percentage of indicators of Opinion 87.2, Response 83.51%, Meaning 80.75% and Perception 77.49%. First, parents must provide direction and understanding to children about the shows to be watched, as well as provide assistance and explanations, Both parents must provide supervision to the child so that the child will be careful in choosing television shows. Third, provide guidance to children so they want to. watching television shows that educate and uphold moral values so that children can minimize the activities of watching television shows that are not useful, The four admonitions and strict sanctions from parents will provide a deterrent effect when children watch television shows that are not educational, thus parents can direct the child to watch shows that can improve the moral reasoning of junior high school aged children in Simpang Pawuo Hamlet RT 04 RW 02 Pulau Terap Village, Kuok District.
Az elhízással kapcsolatos attitűdök az egészségügyi ellátórendszerben
Authors: Czeglédi Edit
Published: November 2020

Az elfogultság, az előítélet és a diszkrimináció részei az elhízással élők mindennapjainak, még az egészségügyi ellátórendszer vonatkozásában is. Az elhízással kapcsolatos előítéletek a súlyfelesleggel élő páciensekkel való tiszteletlen, megalázó bánásmódhoz vezethetnek, és ronthatják a páciensek gondozásának minőségét is. Az elhízás és annak stigmatizációja között kétirányú kapcsolat feltételezhető: az elhízással élők diszkriminációja gyakori, ugyanakkor a stigmatizációs élmények további súlygyarapodást eredményeznek, emellett az egészségügyi ellátórendszer kerüléséhez, az egészség romlásához és a mortalitás kockázatának növekedéséhez vezetnek. A tanulmány célja a szakemberek tudatosságának növelése az elhízással kapcsolatos előítéletek és diszkrimináció tekintetében, illetve olyan stratégiák bemutatása, amelyek elősegítik az elhízással élők stigmatizációjának csökkentését az egészségügyi ellátórendszerben. Mindez a jobb ellátást szolgálja és hosszú távon népegészségügyi jelentősége lehet.
A cukorbetegség és szemészeti szövődményeinek epidemiológiai vonatkozásai hazánkban
Authors: Tóth Gábor , Németh János
Published: November 2020

A diabetes mellitus civilizációs betegség, ami a fejlett országokban a dolgozó korú lakosság körében a vakság kialakulásának vezető oka. Hazánkban a cukorbetegség prevalenciája 9,9%-ra tehető a felnőttkorúaknál, ami alapján 2015-ben 807 000 főre becsülték a cukorbetegek számát e korcsoportban. Csaknem minden ötödik cukorbetegnek van valamilyen cukorbetegség okozta szemészeti szövődménye Magyar­or­szágon, közülük 0,3% vak és 0,3% sú­lyos látássérült a nem megfelelően kezelt cukorbetegség és diabeteses retinopathia miatt. A diabeteses retinopathia prevalenciaalapú költségterhe 2018-ban 43,66 milliárd Ft volt Magyarországon. A két fő költségviselő az antiVEGF injekciók és a vitrectomia műtétek voltak; a költségek több mint négyötödéért ezen két tétel volt felelős. A cu­korbetegség és az elhízás elleni küzdelemben előtérbe kell helyeznünk a prevenciót, ezzel együtt az egészséges táplálkozást, a gyakori testmozgás és a fizikai aktivitás szük­ségességét. Cukorbetegeknél az évenként elvégzett szemészeti ellenőrzésekkel és a diabeteses retinopathia megfelelő időben való kezelésével a cukorbetegség szövődményeként kialakuló látásromlás és vakság megelőzhető.
Strange Characters: Dialogic Selves and Cosmopolitanism in Carl Van Vechten's Peter Whiffle
Authors: Scuriatti Laura
Published: November 2020

Carl Van Vechten's novel Peter Whiffle. His Life and Works (1922) is a work of ‘autobiografiction’, merging biography and autobiography, and drawing attention to the fictional elements of life writing. It problematizes authorship and posits selfhood as a dialogic, polyphonic construct, dependent on the strategies, content and structure of narrative. The article explores the complex intertextual presence of George Moore's Confessions of a Young Man in Van Vechten's novel: they both propose different aspects of a similar story of two friends with cosmopolitan and refined tastes, whose subjectivities are mediated by constant references to other literary characters, and who depend on one another's narratives to have access to their own selves, or at least to become authors of works of art about themselves. Drawing on Adriana Cavarero's and Lucia Boldrini's studies on auto/biographical selves, and on Rebecca Walkowitz's and Homi Bhabha's theories of cosmopolitanism, the article argues that Peter Whiffle's emphasis on dialogic subjectivity questions the notion of authorship and creates a problematic, parodic form of cosmopolitanism. This type of cosmopolitanism does not contribute to any productive experiences of self-knowledge or of knowledge of the foreign ‘other’, but rather asks crucial questions on the very possibility of these experiences.
Romantic Fungi and Other Useless Things: Arnold, Tieck, Keats
Authors: Henning Peter
Published: November 2020

The following study centres on the motif of the mushroom in romantic poetry, discussing the questions of meaning, use, and indeterminacy that it raises. By analyzing the work of Matthew Arnold, Ludwig Tieck, and John Keats, the article outlines a particular field of semiosis, initially sought out in the border zone between natural and artificial. Importantly, however, each of the examples also actualize a disturbance in that field, suggestive of a poetic capacity beyond the dictum of functionality and efficacy. The investigation furthermore documents a fixation with detail, attempting to theorize its allure with the aid of Roland Barthes and his concept of the ‘third meaning’. Connecting the affective ‘sting’ of the detail with the question of poetic non-function, the study ultimately proposes that a concern for the reading and writing body might fill the space of meaning vacated by poets such as Tieck and Keats.