bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: Phosphorane‐Phosphate Tautomerism of 2,2,2‐Trichloro‐1,3,4,2λ5‐oxadiazaphospholines.
Authors: TUPCHIENKO S. K. , DUDCHENKO T. N. , SINITSA A. D.
Published: May 2016

The carboxylic hydrazides (I) are coupled with phosphorus pentachloride (II) to give the oxadiazaphospholines (III) mentioned in the title or the spiro compounds (IX) depending on the molar ratio.
ChemInform Abstract: Metal Complexes with Tetrapyrrole Ligands. Part 54. Synthesis, Spectra, Structure, and Redox Properties of Cerium(IV) Bisporphyrinates with Identical and Different Porphyrin Rings in the Sandwich System.
Authors: BUCHLER J. W. , DE CIAN A. , FISCHER J. , HAMMERSCHMITT P. , LOEFFLER J. + , SCHARBERT B. , WEISS R.
Published: May 2016

The sym. bis(porphyrinates) (Ia)‐(Ic) are obtained from the free base and Ce(III) acetylacetonate in trichlorobenzene at reflux temperature.
ChemInform Abstract: Oxidative Conversions of Labdanediols. Part 5. Reaction of Sclareol with a Heteropoly Acid Containing Thallium.
Authors: CHERNENKO G. F. , GOLIKOVA M. A. , ROMANCHENKO T. V. , SHMIDT E. N. , MATVEEV K. I. , PENTEGOVA V. A.
Published: May 2016

Treatment of sclareol (I) with the sodium thallotungstenophosphate Na4PW11TlO39, whose preparation is described in MeOH, affords the novel polyfunctional derivatives (III)‐(VI).
ChemInform Abstract: Jasmonoids. Part 2. Two Jasmonate‐Type Cyclopentanone‐Based Dimethyl Esters from 10‐Undecenoic Acid.
Authors: NAYAK U. R. , DEODHAR V. B. , DALAVOY V. S.
Published: May 2016

Reaction of the ester (I), a pyrolysis product of castor oil, with manganic acetate gives the lactone (III) which is transformed to the title compound (VII) via the cyclopentenone (V).
ChemInform Abstract: Synthesis and QSAR of 1‐Aryl‐4‐(β‐2‐quinolyl/1‐isoquinolylethyl)piperazines and Some Related Compounds as Hypotensive Agents.
Authors: MURTI A. , BHANDARI K. , RAM S. , PRABHAKAR Y. S. , SAXENA A. K. , JAIN P. C. , GULATI A. K. , SRIMAL R. C. , DHAWAN B. N. , NITYANAND S. , ANAND N.
Published: May 2016

About 50 title compounds are prepared and tested for their pharmacological activities.
ChemInform Abstract: Conduction in a‐SiN:H and a‐SiON:H Alloys.
Authors: OSENBACH J. W. , KNOLLE W. R. , ELIA A.
Published: May 2016

The title alloys are plasma‐deposited on p‐type wafers using 2% SiH4 in N2 and N2O as the reaction gases (0.7 kW, 380 kHz, 0.36 torr, 200‐350 °C), and their electrical properties are studied as a function of the deposition temperature.
ChemInform Abstract: Primary and Secondary Lithium Passivation Characteristics and Effects in the Li/SO2 Couple.
Authors: BITTNER H. F.
Published: May 2016

The capacity degradation of commercial Li/SO2 cells observed after long‐term, low rate discharge is attributed to modification of the Li passivation layer which results in increased Li corrosion.
ChemInform Abstract: Electrochemistry of Manganese Dioxide in Lithium Nonaqueous Cell. Part 1. X‐Ray Diffractional Study on the Reduction of Electrolytic Manganese Dioxide.
Authors: OHZUKU T. , KITAGAWA M. , HIRAI T.
Published: May 2016

The XRD data obtained during the electrochemical reduction of heat‐treated (250 °C and 400 °C, 7 d) electrolytic MnO2 cathodes in a lithium nonaqueous cell indicate that the reaction occurs via electron injection and Li+ insertion to form a LixMnO2 phase without destruction of the core structure.
ChemInform Abstract: Preparation of InX (X: P, As, Sb) Thin Films by Electrochemical Methods.
Authors: ORTEGA J. , HERRERO J.
Published: May 2016

InSb and InAs thin films are electrodeposited from citric acid baths containing InCl3 and SbCl3 or AsCl3 at potentials of ‐0.90 V (vs.
ChemInform Abstract: The First Oxopraseodymate Containing a Triple of Octahedra: Rb2Li14(Pr3O14).
Authors: VOIGT S. , HOPPE R.
Published: May 2016

Single crystals of the title compound are prepared by solid state reaction of RbO0.52 and Li8PrO6 (Rb: Pr = 2:3, 590 °C, 60 d).
ChemInform Abstract: TlSPh and TlStBu, Thallium(I) Thiolates with Novel Cagelike Structural Units: (Tl5(SPh)6)‐/(Tl7(SPh)6)+ and (Tl8(StBu)8).
Authors: KREBS B. , BROEMMELHAUS A. +
Published: May 2016

Tl(I) thiolates, known since 40 years, are obtained for the first time in crystalline form, suitable for structural investigations.
ChemInform Abstract: Aromatic Nucleophilic Substitution Reactions of 1‐Dialkylamino‐2,4‐dinitronaphthalenes with Various Amines in Dimethyl Sulfoxide. Part 26.
Authors: SEKIGUCHI S. , SUZUKI T. , HOSOKAWA M.
Published: May 2016

The substitution reactions of the N,N‐dimethyl analogue of (I) with prim. amines such as (VI) show that benzylamine (VIa) is more reactive than aromatic prim. amines such as (VIb) but less reactive than aliphatic prim. ones.
ChemInform Abstract: Acid‐Catalyzed Hydrolysis of Bridged Bi‐ and Tricyclic Compounds. Part 27. An Application of the Excess Acidity Method to the Norbornyl Cation Problem.
Authors: LAJUNEN M. , HIMOTTU M.
Published: May 2016

From the rate ratio for the hydrolyses of (I) and (V), it is assumed that the reactions involve the rate‐limiting formation of the non‐classical norbornyl cation (II).
ChemInform Abstract: Lewis Acid Catalysis of Photochemical Reactions. Part 8. Photodimerization and Cross‐Cycloaddition of Coumarin.
Authors: LEWIS F. D. , BARANCYK S. V.
Published: May 2016

Coumarin (I) forms 1:1 complexes with the Lewis acids BF3 and EtAlCl2, resp. (UV, IR, fluorescence, 1H NMR, equilibrium constants).
ChemInform Abstract: Photolysis of 1,1,1‐Triarylhept‐2‐ynes. Generation of Phenyl(hex‐1‐ynyl)carbene.
Authors: SHI M. , OKAMOTO Y. , TAKAMUKU S.
Published: May 2016

The symmetrical triaryl‐2‐heptynes (I) are photolyzed in methanol (II) and form via discussed intermediates mixtures of the diphenyls (III) and the methylethers (IV).
ChemInform Abstract: Radical Cation Cope Rearrangement of 1,5‐Hexadiyne to 1,2,4,5‐Hexatetraene (Bis(allene)) at 77 K.
Authors: DAI S. , PAPPAS R. S. , CHEN G.‐F. , GUO Q.‐X. , WANG J. T. , WILLIAMS F.
Published: May 2016

Radiolytic oxidation of the title compounds (I) and (III) results in just the same ESR spectrum.
ChemInform Abstract: Oxidative Kinetics of Unsaturated Carboxylic Acids by Bromate in the Presence of Bromo Complex Forming Metal Ions.
Authors: REDDY CH. S.
Published: May 2016

The oxidation of cinnamic acid (I) is studied under various conditions and in the presence of Hg2+ and Tl3+, the ions behaving as bromine complex forming metal ions.
ChemInform Abstract: A Convenient Procedure for Dissolving Metal Reductions.
Authors: MARKGRAF J. H. , WAUGH STALEY S. , ALLEN T. R.
Published: May 2016

The cyclic enones (I), (III), and (VI) are subjected consecutively to reduction with lithium in ethylenediamine and Jones oxidation, yielding the corresponding cyclic ketones (II), (IV) and (V), or (VII) and (VIII).
ChemInform Abstract: Generation of Alkoxyl Radicals from O‐Alkyl Benzenesulfenates.
Authors: BECKWITH A. L. J. , HAY B. P. , WILLIAMS G. M.
Published: May 2016

Treatment of the O‐(cyclo)alkyl benzenesulfenates (I), (IV), and (VII) with tributylstannane in the presence of azo‐bis‐isobutyronitrile results in the formation of the alcohols (II), (V), or (VIII), together with 2‐methyltetrahydrofuran (III) or the carbonyl compounds (VI) and (IX).
ChemInform Abstract: Synthesis of Unsymmetrical Dialkynylimines. Stepwise Coupling of N‐Phenyl Phenylthioimidoyl Chloride with Alkynyltin Compounds.
Authors: ITO Y. , INOUYE M. , MURAKAMI M.
Published: May 2016

The chlorothioimidate (I) reacts with the tributylstannylalkynes (II) in the presence of Pd catalysts to give the alkynecarbothioimidates (III) which are further alkylated or silylated with (II) or the Grignard compounds (VI) to form the disubstituted imines (IV) or (VII).
ChemInform Abstract: Reaction of 2‐Hydroxyethyl‐N‐alkyl Carbamates with Alcohols and Amines.
Authors: MIKHEEV V. V.
Published: May 2016

Aliphatic N‐substituted carbamates are able to react with compounds with an active proton, if these carbamates have a β‐hydroxysubstituted alkoxy group.
ChemInform Abstract: Synthesis of 2‐N,N‐Dialkylamino‐3‐chloro‐5,5‐bis(methylthio)‐2‐cyclopentene‐1,4‐diones.
Authors: TALZI V. P. , BEK N. O. , DAVLETSHINA A. M. , GUDOSHNIKOV S. K. , SAPOZHNIKOV YU. E.
Published: May 2016

The dione (I) is known for its fungicidal and bactericidal activity.
ChemInform Abstract: Synthesis of 2‐Butanoyl‐3‐alkylamino‐2‐cyclohexene‐1‐ones.
Authors: LAKHVICH F. A. , RUBINOV D. B. , LIS L. G. , RUBINOVA I. L.
Published: May 2016

In the presence of pyridine the enaminoketones (I) undergo C‐acylation on treatment with butanoyl chloride (II) to give the title compounds (III).
ChemInform Abstract: Reaction of 3,7‐Dimethylenebicyclo(3.3.1)nonane with the Pyridinium Salts of Perfluorocarboxylic Acids.
Authors: SOLOSHONOK V. A. , KHOTKEVICH A. B. , SERGUCHEV YU. A.
Published: May 2016

A molten mixture of the title compounds (I) and (II) undergoes exothermic reaction to give the adamantyl esters (III) in fair yields.
ChemInform Abstract: Host‐Guest Complexation. Part 51. Cyanospherands, a New Type of Salt Binder.
Authors: PAEK K. , KNOBLER C. B. , MAVERICK E. F. , CRAM D. J.
Published: May 2016

From 1H NMR data the conformations of the spherands (III)‐(V), the degree of hindrance to rotation about the aryl‐aryl bonds in the tetramer (IIb), and thermodynamic data and conformations of the spheraplexes derived from (III)‐(V) with some cations such as Li+, Na+, K+, R‐NH3+ (R: ‐H, ‐Me, ‐tBu) are deduced.
ChemInform Abstract: Selective Ion Extraction by a Calix(6)arene Derivative Containing Azo Groups.
Authors: NOMURA E. , TANIGUCHI H. , TAMURA S.
Published: May 2016

The tert‐butylcalixarene (I) is dealkylated with AlCl3 and then coupled with phenyldiazonium chloride (III) to give the phenylazocalix(6)arene (IV).
ChemInform Abstract: Synthesis and Reactions of 3,4‐Bis(trimethylsilyl)furan and 2‐Methyl‐3,4‐bis(trimethylsilyl)furan.
Authors: HO M. S. , WONG H. N. C.
Published: May 2016

The oxazoles (I) react with bis(trimethylsilyl)acetylene (II) to give the bis(trimethylsilyl)furans (III).
ChemInform Abstract: A Convenient One‐Flask Synthesis of α‐Methylene Aldehydes from Primary Alcohols.
Authors: TAKANO S. , INOMATA K. , SAMIZU K. , TOMITA S. , YANASE M. , SUZUKI M. , IWABUCHI Y. , SUGIHARA T. , OGASAWARA K.
Published: May 2016

The hydroxyethyl derivatives (I) are subjected to Swern oxidation to form the aldehydes (II) which are directly treated with the iminium salt (III), yielding the α‐substituted acroleines (IV).
ChemInform Abstract: Palladium‐Assisted Heteroannulation of Acetoxy‐1,3‐dienes.
Authors: LAROCK R. C. , SONG H.
Published: May 2016

2‐(Chloromercurio)benzoic acid (I) undergoes ring closure reaction with the acetoxydienes (II) or (IV) in the presence of lithium chloropalladates to form the dihydrobenzopyranones (III) or (V).
ChemInform Abstract: Synthesis in the Phenanthridine Series. Part 1. Preparation of 6‐Alkylphenanthridines and Their Salts.
Authors: LION C. , BOUKOU‐POBA J. P. , CHARVY C.
Published: May 2016

Phenanthridines show interesting biological activities, e.g. antileukemic and antidepressive activity.
ChemInform Abstract: Methods for Controlling the Regioselection in the Reaction of 3‐Amino‐5‐benzylthio‐1,2,4‐triazole with Acetylacetaldehyde Dimethyl Acetal.
Authors: MONTE W. T. , KLESCHICK W. A. , MEIKLE R. W. , SNIDER S. W. , BORDNER J.
Published: May 2016

Depending on the conditions, the reaction between the title compounds (I) and (II) affords the triazolo(1,5‐a)pyrimidine (III) or its 7‐methyl isomer (IV).
ChemInform Abstract: Benzimidazole Condensed Ring Systems. Part 5. Studies on the Synthesis of Pyrimido(1,6‐a)benzimidazole‐1,3(2H,5H)‐diones.
Authors: BADAWEY E. A. M. , RIDA S. M. , SOLIMAN F. S. G. , KAPPE T.
Published: May 2016

The reaction between ethyl 1H‐benzimidazole‐2‐acetate (I) and the alkyl isocyanates (II) yields the expected title compounds (III), which are further converted to the 5‐alkyl derivatives (V) and the 4‐chloro derivatives (VI).
ChemInform Abstract: Potential Antidepressants. Synthesis of 6,11‐Dihydrodibenzo(b,e)thiepin‐11‐yl 4‐(Dimethylaminomethyl)phenyl Ketone and of Some Related Compounds.
Authors: SINDELAR K. , HOLUBEK J. , SVATEK E. , MATOUSOVA O. , METYSOVA J. , PROTIVA M.
Published: May 2016

Numerous attempts to convert the alcohols (III) and (V) into the corresponding ketones remain unsuccessful.
ChemInform Abstract: Phosphaalkenes from Monochlorophosphanes and Alkylidenetriphenylphosphoranes.
Authors: MAERKL G. + , BAUER W.
Published: May 2016

The mono‐ and disubstituted, nonstabilized methylenetriphenylphosphoranes (I) can be converted by transylidation with the monochlorophosphane (II) into the kinetically more stable phosphaalkenes (IV).
ChemInform Abstract: Generation, Stereochemistry, and Molecular Dynamics of a 1,3‐Bis(phosphonio)propenide Cation.
Authors: SCHMIDBAUR H. , PASCHALIDIS C. , STEIGELMANN O. , MUELLER G. +
Published: May 2016

A useful model for the free allyl anion is the methyldiphosphoniopropenide (IV) (space group P21/n, Z=4).
ChemInform Abstract: 1,1‐Dimetallagermacyclopent‐3‐enes: Precursors to Transition Metal‐Substituted Germylenes (Germanediyls).
Authors: LEI D. , SMITH M. J. H.
Published: May 2016

The germacyclopentenes (I) are coupled with the metal carbonyl complexes (II) to give the 1,1‐ditransition metal‐substituted germacyclopentenes (III).
ChemInform Abstract: Optically Active Isoprene(tricarbonyl)iron(0) and Methyltrimethylenemethane(tricarbonyl)iron(0).
Authors: KAPPES D. , GERLACH H. , ZBINDEN P. , DOBLER M. , KOENIG W. A. + , KREBBER R. , WENZ G.
Published: May 2016

Ionic hydrogenation of (I) gives rise for the first time to the optically active title complexes (II) and (III).
ChemInform Abstract: Reactions of Cobalt(II) Macrocycles with Alkyl and Alkylperoxy Radicals.
Authors: BAKAC A. , ESPENSON J. H.
Published: May 2016

The Co‐C bond formation in the reactions of complexes such as (I)‐(IV) with primary alkyl and substituted primary alkyl radicals takes place with rate constants in the range 107‐109 M‐1 s‐1 The kinetics are influenced by the nature of the macrocycle to a much greater extent than by the nature of the radicals, such that all the rate constants for a given cobalt complex fall within a factor of ∼2.
ChemInform Abstract: (Tetramethylthiophene)ruthenium Dichloride Dimer: A Versatile Synthetic Intermediate in Thiophene Coordination Chemistry.
Authors: LOCKEMEYER J. R. , RAUCHFUSS T. B. , RHEINGOLD A. L. , WILSON S. R.
Published: May 2016

Thermal arene exchange in (I) yields the title dimer (III).
ChemInform Abstract: Preparation and X‐Ray Crystal Structure of (RhPh(OCOCF3)(C10H4NO2)(P(p‐FC6H4)3)(H2O)), an Octahedral Complex Containing a σ‐RhPh Bond.
Authors: CANO M. , HERAS J. V. , LOBO M. A. , PINILLA E. , GUTIERREZ E. , MONGE M. A.
Published: May 2016

New complexes of the title type (I) (space group P1, Z=2) are obtained by elimination of Hg from the intermediate heterobimetallic complexes Rh(OCOCF3)(HgPh)(O‐N)(CO)L (L: P(p‐RC6H4)3; R: Cl, F, Me, OMe).
ChemInform Abstract: Hydrocarbon‐Bridged Complexes. Part 14. Directed Synthesis of Trinuclear Hydrocarbon‐Bridged Complexes Such as ((CO)5ReCH2CH2Os(CO)4CH2CH2Re(CO)5).
Authors: BECK W. , NIEMER B. , WAGNER B.
Published: May 2016

Nucleophilic addition of carbonyl metalates to coordinated, unsaturated hydrocarbons in cationic complexes is used for the title reaction as shown for the example of (III).
ChemInform Abstract: Inter‐ and Intramolecular Photochemical C‐H Activation with (η6‐Arene)(carbonyl)osmium Complexes in Matrices and in Solution.
Authors: MCCAMLEY A. , PERUTZ R. N. , STAHL S. , WERNER H.
Published: May 2016

Arene‐osmium complexes (I), (IV) and (V) undergo inter‐ or intramolecular C‐H activation reactions on photolysis in low‐temp.
ChemInform Abstract: Characterization of (Methylcyclopentadienyl)trimethylplatinum and Low‐Temperature Organometallic Chemical Vapor Deposition of Platinum Metal.
Authors: XUE Z. , STROUSE M. J. , SHUH D. K. , KNOBLER C. B. , KAESZ H. D. , HICKS R. F. , WILLIAMS R. S.
Published: May 2016

Thin films of platinum are used extensively in microelectronics device processing and electrodeless metal plating.
ChemInform Abstract: A Formal Stereocontrolled Synthesis of (.+‐.) Isoclovene.
Authors: AHMAD Z. , GOSWAMI P. , VENKATESWARAN R. V.
Published: May 2016

The diketone (XVII) and the tricyclic ketone (XVIII) represent immediate precursors of isoclovene (XIX), the artifact isolated from extensive rearrangement of caryophyllene.
ChemInform Abstract: Improved Synthesis of the Biologically Active Methionine Analog, L‐2‐Amino‐4‐methoxy‐cis‐but‐3‐enoic Acid (L‐cis‐amb) Using an Electrophilic Glycinate Synthon.
Authors: ALKS V. , SUFRIN J. R.
Published: May 2016

The methyl glyoxylate hemiacetal (I) is treated with acetamide (II) and then subjected to substitution of the hydroxy group, producing the N‐acetylbromoglycinate (IV).
ChemInform Abstract: N‐Formylglycine tert‐Butyl Ester.
Authors: MEDUNA V. , SAWLEWICSZ P. , VOGT R.
Published: May 2016

Two methods of preparing the title compound (III) are described: the first procedure consists in coupling deprotonated formamide (I) with tert‐butyl chloroacetate (II) to yield a mixture of (III) and its N,N‐diformyl derivative (IV).
ChemInform Abstract: C‐Stannylated Carbohydrate Derivatives. Part 3. 1,2:5,6‐Di‐O‐isopropylidene‐3‐C‐(organostannyl)methyl‐α‐D‐allofuranose Derivatives. Crystal and Molecular Structure of 3‐C‐(Dibutyliodostannyl)methyl‐1,2:5,6‐di‐O‐isopropylidene‐α‐D‐allofurano# se.
Authors: COX P. J. , DOIDGE‐HARRISON S. M. S. V. , HOWIE R. A. , NOWELL I. W. , TAYLOR O. J. , WARDELL J. L.
Published: May 2016

When the organostannyl carbohydrates (III) are treated with TFA, the expected β‐elimination reaction does not occur.
ChemInform Abstract: Stereochemical Variations in Aqueous Cycloadditions Using Glycoorganic Substrates as a Consequence of Chemical Manipulations on the Sugar Moiety.
Authors: LUBINEAU A. , QUENEAU Y.
Published: May 2016

In the cycloaddition between the dienes (I) and methacrolein (II), the introduction of a sugar moiety induces chirality and water solubility of the starting materials and causes a stereofacial selectivity between the four possible adducts (III)‐(VI).
ChemInform Abstract: Synthesis of (+)‐Sesbanimide A. Structure of the Crucial Silyl Ether AB Ring Intermediate.
Authors: VLOON W. J. , VAN DEN BOS J. C. , WILLARD N. P. , KOOMEN G.‐J. , PANDIT U. K.
Published: May 2016

Silylation of the known sesbanimide precursor (I) does not result in the expected protection of the hydroxy group but rather leads to the tricyclic structure (III) (confirmed by an X‐ray structure analysis of (IV)), which is subsequently converted to the title alkaloid (V).
ChemInform Abstract: Synthesis of 2‐(2′,3′‐Dihydroxypropyl)‐5‐amino‐2H‐1,2,4‐thiadiazol‐3‐one and 3‐(2′,3′‐Dihydroxypropyl)‐5‐amino‐3H‐1,3,4‐thiadiazol‐2‐one.
Authors: PARKANYI C. , YUAN H. L. , CHO N. S. , JAW J.‐H. J. , WOODHOUSE T. E. , AUNG T. L.
Published: May 2016

The hitherto unknown title compounds (VIII) and (XII) are the acyclic nucleoside analogues of their precursors i.e. of the thiadiazoles (VI) or (XI), respectively (no yield given for (XI)).
ChemInform Abstract: Synthesis of Some 13‐Oxaprostanoids.
Authors: MJALLI A. M. M. , ROBERTS S. M.
Published: May 2016

Key step in the new preparation of 13‐oxaprostaglandins, biologically interesting compounds, is the reaction of Dps‐Cl (II) with an encumbered secondary hydroxy group in the presence of an adjacent hindered secondary hydroxy group to give the synthon (V).
ChemInform Abstract: The Conformational Analysis of Derivatives of Erythromycin A. X‐Ray Crystallographic and NMR Spectroscopic Studies of (E)‐11‐O‐(2‐Dimethylaminoethoxy)methyl‐9‐deoxo‐9‐methoxyiminoerythromycin A (I).
Authors: EVERETT J. R. , HATTON I. K. , HUNT E. , TYLER J. W. , WILLIAMS D. J.
Published: May 2016

The title compound (I) is synthesized from erythromycin A (e.A) in 4 steps and has space group P212121 with Z=4.
ChemInform Abstract: The Rotational Spectrum and Structure of Chlorine Peroxide.
Authors: BIRK M. , FRIEDL R. R. , COHEN E. A. , PICKETT H. M. , SANDER S. P.
Published: May 2016

With a view to resolving some of the discrepancies concerning the ClO dimer as well as to clarifying its role in the atmosphere the ClO self‐reaction is studied in a flowing chemical reactor using submillimeter wave spectroscopy.
ChemInform Abstract: Photoelectrochemically Synthesized Interfacial Oxides on Silicon: Composition and Electronic Properties.
Authors: LEWERENZ H. J. , STUMPER J. , PETTENKOFER C. , GREEF R.
Published: May 2016

Photoelectrochemically grown oxides on a‐Si:H and Si single crystals are studied by in situ ellipsometry and XPS.
ChemInform Abstract: Enantioselective Microbial Reduction of 5‐Acetylisoxazolines ‐ A Novel Method for Stereochemical Control on Yeast Reduction.
Authors: TICOZZI C. , ZANAROTTI A.
Published: May 2016

The kinetics and stereoselectivity of the baker's yeast reduction of the racemic isoxazole (I) depends strongly on the 2‐propanol/water ratio; at a ratio of 4:1 the reduction allows kinetic resolution leading to ketone (R)‐(‐)‐I and alcohol(+)‐II.
ChemInform Abstract: Addition of N‐Diphenylmethylene(2‐furfuryl)amine to Benzylideneacetophenones.
Authors: POPANDOVA‐YAMBOLIEVA K.
Published: May 2016

Lewis acid‐catalyzed reaction of benzophenone (I) with furfurylamine (II) prouces the imine (III) which is coupled with the aromatic enones (IV) under phase‐transfer conditions, yielding the Michael type adducts (V) as the main products.
ChemInform Abstract: Quantitative Synthesis of L‐ or D‐N2‐tert‐Butoxycarbonyl‐2,3‐diaminopropanoic Acid from Protected L‐ or D‐Serine‐β‐lactone.
Authors: KUCHARCZYK N. , BADET B. , LE GOFFIC F.
Published: May 2016

When the N‐protected amino‐β‐lactone L‐(I) is treated with gaseous ammonia (II) in ethers or with liquid ammonia (II), the serine carboxamide (III) is exclusively formed.
ChemInform Abstract: Electrochemical Synthesis of Bi‐1,4‐naphthoquinonyl Derivatives.
Authors: SCHUTTE J. H. P. , DU PLESSIS J. A. K. , LACHMANN G. , VILJOEN A. M. , NELSON H. D.
Published: May 2016

Electrolysis of 1,4‐naphthoquinone (I) or a mixture of (I) and 2‐amino‐1,4‐naphthoquinone (III) results in the formation of the 2,2'‐bi‐1,4‐naphthoquinones (II) or (V).
ChemInform Abstract: Heterocyclic Compounds from 2‐(Alkoxycarbonylcyanomethylene)‐1,3‐dioxolanes
Authors: NEIDLEIN R. , KIKELJ D. , KRAMER W.
Published: May 2016

(e.g.
ChemInform Abstract: Homochiral Ketals in Organic Synthesis. Diastereoselective Cyclopropanation of Medium and Large Ring α,β‐Unsaturated Ketals Derived from 1,4‐Di‐O‐benzyl‐L‐threitol.
Authors: MASH E. A. , MATH S. K. , ARTERBURN J. B.
Published: May 2016

The cyclic acetals (III), obtained by reaction of the ketones (I) with the threitol derivative (II), are converted into the unsaturated cis‐and trans‐configurated cycloalkenone acetals (IV).
ChemInform Abstract: Silicon‐Sulfur Compounds. Part 55. Isosteric Isobutyl(isopropoxy)silanethiols. Preparation and Spectroscopic Properties.
Authors: PIKIES J. , WOJNOWSKI W.
Published: May 2016

The title compounds (III) are obtained according to the scheme.
ChemInform Abstract: A New Class of Room Temperature Luminescent Organometallic Complexes: Luminescence and Photophysical Properties of Permethylscandocene Chloride in Fluid Solution.
Authors: PFENNIG B. W. , THOMPSON M. E. , BOCARSLY A. B.
Published: May 2016

With the view to searching for organometallic complexes that emit in fluid solution at room temp., photophysics of the d° first row transition‐metal complex (I) are investigated.
ChemInform Abstract: Metal Complexes of Functional Isocyanides. Part 18. (Alkylideneamino)carbenes by Nucleophilic Addition to Pentacarbonylchromium‐Coordinated 1,1‐Dichloromethyl, 1,1,2‐Trichloroethyl and 1‐Chlorovinyl Isocyanide.
Authors: FEHLHAMMER W. P. , BECK G.
Published: May 2016

Pyrrolidine (II) adds to the isocyano group of the Cr complex (I) with concomitant loss of HCl to give the (ethylideneamino)carbene complex (III) in which the α‐chlorine can be replaced by a second molecule of pyrrolidine (II) producing (IVa).
ChemInform Abstract: Organometallic and Coordination Chemistry on Phosphazenes. Part 1. Zn(II), Pd(II) and Pt(II) Complexes on Schiff Base‐Containing Cyclophosphazenes.
Authors: BERTANI R. , FACCHIN G. , GLERIA M.
Published: May 2016

Hexakis(4‐amino‐3‐methylphenoxy)cyclophosphazene (III) is prepared from hexachlorocyclophosphazene (I) according to the scheme.
ChemInform Abstract: A New Structure Type with Face Connected BaO6‐Octahedra: Ba6Nd2Al4O15.
Authors: RUETER I. + , MUELLER‐BUSCHBAUM HK. +
Published: May 2016

In order to prepare single crystals of the title compound, an intimate mixture of BaCO3, Nd2O3, and Al2O3 (6:1:2) is pressed into pellets and heated (more than 2 months) between 1020 and 1250 °C using BaCl2 as a flux.
ChemInform Abstract: Crystal Structure of SbF5·SO2.
Authors: MINKWITZ R. , MOLSBECK W. , PREUT H.
Published: May 2016

SbF5·SO2 crystallizes in the monoclinic system, space group P21/n, Z=4 (single crystal XRD at 162 K).
ChemInform Abstract: YBa2Cu3O7‐x: Transport Properties and Defects at High Temperature.
Authors: CHIODELLI G. , CAMPARI‐VIGANO G. , FLOR G.
Published: May 2016

Resistivity measurements in the temp. range 300‐1023 K under oxygen partial pressures of 5·10‐7‐1 atm indicate a metallic behavior for polycrystalline YBa2Cu3O7‐x equilibrated in the p(O2) range 5·10‐4‐1 atm, a transition between metallic and semiconducting behavior at 920 K for the sample equilibrated at p(O2) = 2·10‐5 atm, and semiconducting behavior for the sample equilibrated at p(O2) = 5·10‐7 atm.
ChemInform Abstract: Difluoro‐ and Dichlorodioxasilirane.
Authors: PATYK A. , SANDER W. , GAUSS J. , CREMER D.
Published: May 2016

Reactions of difluoro‐ and dichlorosilylene with molecular oxygen in Ar matrices are found to produce the dioxasiliranes (III) under irradiation with UV/VIS, while no thermal reaction of (I) with oxygen is observed in the gas phase or in O2‐doped Ar matrices at low temp. (10‐45 K).
ChemInform Abstract: ESR Observation of Enamine Radical Cations from Thiamine (Vitamin B1) and Related Compounds.
Authors: RUEEGGE D. + , FISCHER H.
Published: May 2016

The reduction of thiamine and thiazolium salts by photochemically generated radicals such as ·CMe2‐OH and ·CH2OH leads to radical cations such as (I) and (II); (IIb) is accompanied by (III).
ChemInform Abstract: Thermal Decomposition of Energetic Materials. Part 34. Decarbonylation, Decarboxylation, and Coupling Reactions of Metal Propiolates, M(O2CCCH).
Authors: STONER C. E. JUN. , BRILL T. B.
Published: May 2016

The slow and rapid thermal decomposition of group IA (Na+, K+, Rb+) and first‐row transition‐element (Co2+, Ni2+, Zn2+) propiolate salts is investigated by TGA, DSC, and IR spectroscopy.
ChemInform Abstract: Topological and Steric Effects in Mechanism of Intramolecular (2 + 2)‐Photocycloadditions.
Authors: BECKER D. , HADDAD N. , SAHALI Y.
Published: May 2016

The 2‐alkenylcyclohexenones (I) undergo photo‐induced ring closure, yielding the tricyclic ketones (II) and (III).
ChemInform Abstract: Water‐Soluble Self‐Doped 3‐Substituted Polypyrroles.
Authors: HAVINGA E. E. , TEN HOEVE W. , MEIJER E. W. , WYNBERG H.
Published: May 2016

The preparation of the pyrroles (V) and their electrochemical polymerization are described.
ChemInform Abstract: Heterocyclization of Thionocarboxylic Acid Derivatives to 1,3,4‐Thiadiazoles by tert‐Butyl Hypochlorite.
Authors: DEMCHUK D. V. , LUTSENKO A. I. , TROYANSKII E. I. , NIKISHIN G. I.
Published: May 2016

The thiobenzohydrazides (I) undergo heterocyclization upon treatment with tert‐butyl hypochlorite, producing the symmetrically substituted 1,3,4‐thiadiazoles (II).
ChemInform Abstract: Reaction of (Z)‐β‐Enamino λ5‐Phosphazenes and Dimethyl Acetylenedicarboxylate.
Authors: BARLUENGA J. , LOPEZ F. , PALACIOS F.
Published: May 2016

Enamines of type (I) with a substituent ≠ H at the α‐position of the phosphorus atom react with the diester (II) in MeCN at room temperature to give P‐heterocycles of type (IV).
ChemInform Abstract: Silver Ion‐Catalyzed Cyclization of Allenic Phosphonic Acids to 1,2‐Oxaphospholenes.
Authors: MUALLA M. , MACOMBER R. S.
Published: May 2016

Silver nitrate mediates the cyclization of the allenic phosphinic acid (I) to yield the oxaphospholene (II).
ChemInform Abstract: Synthesis and Solid‐ and Liquid‐State Characterization of a Hexameric Cluster of Titanium(IV): Ti6(μ2‐O)2(μ3‐O)2(μ2‐OC4H9)2(OC4H9)6(OCOCH3)8.
Authors: DOEUFF S. , DROMZEE Y. , TAULELLE F. , SANCHEZ C.
Published: May 2016

Air‐moisture sensitive crystals of the title cluster (I) (space group P21/c, Z=2) are obtained from the 1:2 molar reaction of Ti tetrabutoxide and acetic acid within a few days.
ChemInform Abstract: Mono‐ and Dicarbonyl Complexes of Decamethylchromocene. A CO‐Induced η5 → η3 Ring Shift.
Authors: VAN RAAIJ E. U. , BRINTZINGER H. H. , ZSOLNAI L. , HUTTNER G.
Published: May 2016

Decamethylchromocene (I) reacts with CO (II) at ambient pressure to form the 18‐electron complex (III).
ChemInform Abstract: Dimetalla‐Arsacumulenium Ions.
Authors: STRUBE A. , HUTTNER G. , ZSOLNAI L.
Published: May 2016

Title ions such as in (II) (space group P1, Z=2) are prepared by halide abstraction from the arsinidene compound (I).
ChemInform Abstract: Structures of SF5‐Substituted Metal Complexes.
Authors: DAMERIUS R. , LEOPOLD D. , SCHULZE W. , SEPPELT K.
Published: May 2016

The complexes (III) and (VI) (for both space group P21/n Z=4) are formed as expected; the complex (IX) (space group Pmcn, Z=4) is a product of an unclear reaction pathway.
ChemInform Abstract: Investigations on the UV/VIS Spectroscopic Behavior of Azo Dyes. Part 22. Blue Azo Dyes Based on 3‐Cyano‐6‐hydroxy‐2‐pyridones.
Authors: MUSTROPH H.
Published: May 2016

A variety of title dyes such as (III) are prepared and their UV/VIS spectroscopic data are compared with those of the corresponding pyrazolone dyes (IV).
ChemInform Abstract: A Concise Route to (S)‐Phenylalanine from (R)‐Epichlorohydrin.
Authors: TAKANO S. , YANASE M. , OGASAWARA K.
Published: May 2016

(R)‐Epichlorohydrin (I) is cleaved with phenyllithium (II) to give 3‐chloro‐2‐hydroxy‐1‐phenylpropane (III) which is cyclized to produce the benzyloxirane (IV).
ChemInform Abstract: Host Structure Modification Upon Lithium Intercalation in Transition Metal Chalcogenides
Authors: BREC R.
Published: May 2016

Review: (e.g.
ChemInform Abstract: Charge Transfer Processes at WSe2 Electrodes with pH‐Controlled Stability.
Authors: SINN C. , MEISSNER D. , MEMMING R.
Published: May 2016

In aqueous solution of low pH, the energy bands at the surface of n‐WSe2 become unpinned upon illumination.
ChemInform Abstract: Chromium Carbide Electrodeposition in Molten Fluorides.
Authors: STERN K. H. , ROLISON D. R.
Published: May 2016

The chemistry and electrochemistry related to the electrodeposition of chromium carbide from fluoride melts (i.e., the ternary (Li, Na, K) F fluoride eutectic, FLINAK) is studied.
ChemInform Abstract: Relative and Absolute Configurational Assignments of Acyclic Polyols by Circular Dichroism. Part 1. Rationale for a Simple Procedure Based on the Exciton Chirality Method.
Authors: WIESLER W. T. , NAKANISHI K.
Published: May 2016

A general procedure for assigning multiple stereocenters in acyclic polyols is presented.
ChemInform Abstract: Unequivocal Proof of Slowed Chromium Tricarbonyl Rotation in a Sterically Crowded Arene Complex: An X‐Ray Crystallographic and Variable‐Temperature High‐Field NMR Study of (C6Et5COCH3)Cr(CO)3.
Authors: DOWNTON P. A. , MAILVAGANAM B. , FRAMPTON C. S. , SAYER B. G. , MCGLINCHEY M. J.
Published: May 2016

The title compound (I) crystallizes in the space group P1 with Z=2.
ChemInform Abstract: Use of β‐Sulfonylvinyl Ketones as Equivalents to Vinyl Ketones in Robinson Anellation. Convergent, Highly Stereoselective Preparation of a Hydrindanol Related to Vitamin D from 2‐Methylcyclopent‐2‐enone and Lithiated E‐But‐2‐enyldiphenylphosphine Oxide.
Authors: HAYNES R. K. , VONWILLER S. C. , HAMBLEY T. W.
Published: May 2016

Conjugate addition of lithiated butenyldiphenylphosphine oxide to the cyclopentenone (III) yields the intermediate enolate (IV) which reacts with the β‐sulfonylvinyl ketones (V) to form the unsaturated diketones (VI).
ChemInform Abstract: Photochemical Addition of Methanol to Stilbenes.
Authors: WONING J. , OUDENAMPSEN A. , LAARHOVEN W. H.
Published: May 2016

The photochemical addition of methanol (II) to stilbene (I) involves two competitive pathways: direct addition of methanol to the alkenic bond or insertion of a carbene (VI), emerging from a 1,2‐H shift in (I) to methanol.
ChemInform Abstract: Direct Measurement of the Absolute Kinetics of Chlorine Atom in CCl4.
Authors: CHATEAUNEUF J. E.
Published: May 2016

Identical transient species are generated by nanosecond time‐resolved pulse radiolysis as well as by 266‐nm laser flash photolysis of liquid CCl4.
ChemInform Abstract: Convenient Unimolecular Sources of Aryloxyl Radicals. Part 1. Aryloxyoxalyl Chlorides.
Authors: MODARELLI D. A. , ROSSITTO F. C. , LAHTI P. M.
Published: May 2016

The phenols (I) are consecutively treated with butyllithium and oxalyl chloride (II) to give the aryloxyoxalyl chlorides (III).
ChemInform Abstract: Oxidation by Cobalt(III) Acetate. Part 12. Stereoselective Formation of threo‐1‐Phenylpropane‐1,2‐diol Monoacetate in Oxidation of β‐Methylstyrenes Unsubstituted and Substituted with Electron‐Donating Groups by Cobalt(III) and Manganese(III) Acetate in Acetic Acid.
Authors: HIRANO M. , HAMAGUCHI T. , ZHANG X. , MORIMOTO T.
Published: May 2016

The oxidation of (E)‐ or (Z)‐β‐methylstyrenes such as (I) by Co(O‐Ac)3 or Mn(O‐Ac)3 in AcOH or AcOH/TFA leads to the threo mono‐ and diacetates (III) and (V) as main products.
ChemInform Abstract: Oxidation of Sulfide by Iodylarenes in the Presence of Vanadyl Acetylacetonate as a Catalyst.
Authors: BARRET R. , PAUTET F. , BORDAT P. , TINLAND B. , DAUDON M.
Published: May 2016

Oxidation of the aryl sulfides (I) with iodylbenzene in the presence of vanadyl acetylacetonate gives the sulfoxides (II), sulfones (III), and disulfides (IV).
ChemInform Abstract: A Convergent Synthesis of Polyol Chains.
Authors: RYCHNOVSKY S. D.
Published: May 2016

Coupling of the stannyl‐1,3‐dioxane (I) with the oxirane (II), both prepared by several steps from (S)‐malic acid, yields stereoselectively the alcohol (III).
ChemInform Abstract: Pyrrolidine‐Catalyzed Reactions Between α,β‐Unsaturated Carbonyl Compounds and Cyclopentadiene: A Convenient Approach to 1,2‐ and 1,5‐Dihydropentalenes.
Authors: GRIESBECK A. G.
Published: May 2016

The reaction of cyclopentadiene (I) with α,β‐unsaturated carbonyl compounds is catalyzed by pyrrolidine to yield Diels‐Alder adducts such as (III) or pentafulvalenes such as (V) or (VII).
ChemInform Abstract: Functional Group Manipulation Along the Perimeter of a Hemispherical Molecule. Synthesis of Dihydro‐ and Tetrahydro‐C16‐hexaquinacene.
Authors: PAQUETTE L. A. , GALATSIS P.
Published: May 2016

The diol (I), obtained by reduction of the corresponding dione, is converted to the bis(phenylthio) derivative (III) which is desulfurized by treatment with lithium in liquid ammonia to form the tetrahydro‐C16‐hexaquinacene (IV).
ChemInform Abstract: Antioxidant Effect and Antimicrobial Activity of Phenolic Sulfides.
Authors: ASAKURA K. , MATSUMURA S. , YOSHIKAWA S. , KAWADA K. , UCHIBORI T.
Published: May 2016

Ethanethiol (I) reacts with o‐vinylphenol (IIa) or p‐vinylphenol (IIb) to give the thioethers (III).
ChemInform Abstract: Generation of F‐Alkyl‐Substituted Vinyl Thionium Ion Intermediates and Their Reaction with Silyl Enol Ethers. A New Route to δ‐F‐Alkyl‐α,β;γ,δ‐Unsaturated Carbonyl Compounds.
Authors: ISHIHARA T. , SHINOZAKI T. , KUROBOSHI M.
Published: May 2016

The fluoroalkenyl sulfoxides (I) are treated with trimethylsilyl triflate (II) to give the thionium salts (III).
ChemInform Abstract: Scope of Tandem Cycloaddition/Radical Cyclization Methodology.
Authors: GHOSH T. , HART H.
Published: May 2016

Coupling of 2‐bromobenzyl bromide (II) with lithiated furan yields the derivative (III) which undergoes Diels‐Alder reaction with benzyne, generated in situ from anthranilic acid (IV) and isoamyl nitrite.
ChemInform Abstract: Synthesis, Stereochemistry, and Pharmacological Activity of 1‐(2‐(3,4‐Dimethoxyphenyl)ethyl)‐2‐methyl‐4‐ketodecahydroquinoline and Corresponding Acetylenic Alcohols.
Authors: PRALIEV K. D. , FISHCHUK E. V. , ROZHNOV V. B. , KURBAT N. M. , VDOVICHENKO V. P. , STANKEVICH P. B.
Published: May 2016

Reaction of the propenyl cyclohexenyl ketone (I) with the dimethoxyphenethylamine (II) gives the perhydroquinolone (III) which is coupled with the acetylene (IV), producing the ethynyl carbinols (V) and (VI).
ChemInform Abstract: A Cycloaddition Route to 14‐Hydroxy Steroids.
Authors: KIRSCH G. , GOLDE R. , NEEF G.
Published: May 2016

The acylnitroso compound, prepared in situ by oxidation of the N‐hydroxy carbamate (VII), reacts with the steroidal dienol (I), yielding the isomeric adducts (III) and (IV) which can be hydrogenated to give the diastereomeric alcohols (VI) and (V).
ChemInform Abstract: An Improved Synthesis of L‐Homohistidine.
Authors: ALTMAN J. , WILCHEK M. , LIPP R. , SCHUNACK W.
Published: May 2016

The known diazo ketone (II) is prepared from the N‐protected glutamic acid (I) by a procedure described in the literature.
ChemInform Abstract: Preparative Synthesis of C‐(α‐D‐Glucopyranosyl)alkenes and ‐alkadienes: Diels‐Alder Reaction.
Authors: DE GARCIA GARCIA MARTIN M. , HORTON D.
Published: May 2016

The synthesis of the α‐C‐glucosylalkadiene (III) or the α‐C‐glucosylpropene (V) is achieved by reaction of the p‐nitrobenzoate (I) with the trimethylsilylalkadiene (II) or the silylalkene (IV) in the presence of boron trifluoride etherate.
ChemInform Abstract: Charge‐Transfer Complexes of Urea Derivatives with Tetracyanoethylene.
Authors: NOUR EL‐DIN A. M.
Published: May 2016

The CT spectra of the complexes of TCNE with ureas such as (I)‐(III) in Ac‐O‐Et are measured.
ChemInform Abstract: A Ruthenium Heteropolyanion as Catalyst for Alkane and Alkene Oxidation.
Authors: NEUMANN R. , ABU‐GNIM C.
Published: May 2016

The ruthenium catalyst (IV) is employed in the liquid phase oxidation of adamantane (V) and styrene (IX).
ChemInform Abstract: Diene Chlorination with Manganese Dioxide‐Trimethylchlorosilane.
Authors: BELLESIA F. , GHELFI F. , PAGNONI U. M. , PINETTI A.
Published: May 2016

The chlorination of a variety of dienes with the title reagent to give the corresponding dichloro derivatives is reported.
ChemInform Abstract: Montmorillonite‐Supported Transition Metal Salts as Friedel‐Crafts Alkylation Catalysts.
Authors: CLARK J. H. , KYBETT A. P. , MACQUARRIE D. J. , BARLOW S. J. , LANDON P.
Published: May 2016

Metal halides, fixed on montmorillonite K10, are used as catalysts in the alkylation of benzene (I), fluorobenzene (IV), and phenol (VIII) as outlined in the reaction scheme.
ChemInform Abstract: Synthesis, Spectral Data and Extraction of Copper by 1‐(2′‐Hydroxy‐5′‐alkylphenyl)‐1‐alkanone Oximes.
Authors: KRZYZANOWSKA E. , OLSZANOWSKI A. , JUSKOWIAK M.
Published: May 2016

The title oximes (VIII) are prepared by standard methods as shown in the scheme; the oximes (IX) are analogously prepared.
ChemInform Abstract: Ti(IV)‐Mediated Transesterification and Regio‐ and Stereospecific Cycloaddition of Imines of α‐Amino Esters, Reversal of Normal Regiochemistry.
Authors: BARR D. A. , GRIGG R. , SRIDHARAN V.
Published: May 2016

The N‐arylmethylenamino esters (I) react with methyl acrylate (II) in the presence of tris(isopropoxy)titanium chloride (III) to give the pyrrolidinedicarboxylates (IV) and (V).
ChemInform Abstract: Thiohydrazides and 1,3,4‐Thiadiazoles by Hydrazinolysis of Dithiocarboxylic Esters.
Authors: THIEL W. , MAYER R.
Published: May 2016

Whereas the reaction of dithioesters such as (II) or (VI) with excess hydrazine (IV) gives stable thiohydrazides such as (I) or (V), reaction with 0.5 equiv. (IV) affords thiadiazoles such as (III), (VII).
ChemInform Abstract: 6‐Acetoxy‐9‐selenabicyclo(3.3.1)‐non‐2‐ene: An Unexpected Product of the Se(IV)‐Oxidation of 1,5‐Cyclooctadiene.
Authors: DEHMLOW E. V. , STIEHM T.
Published: May 2016

The compounds (IV) are obtained in the course of investigations of the functionalization of 1,5‐cyclooctadiene.
ChemInform Abstract: Oxo‐Bridged Complexes of Iron(III) Derived from 2‐(2′‐Hydroxyphenyl)benzothiazole and 2‐(2′‐Hydroxyphenyl)benzimidazole Ligands.
Authors: WAHLGREN C. G. , ADDISON A. W. , BURMAN S. , THOMPSON L. K. , SINN E. , ROWE T. M.
Published: May 2016

The oxo‐bridged Fe(III) complexes (I) are prepared and characterized by their magnetic susceptibility and EPR spectra.
ChemInform Abstract: A Novel Bidentate Silicon Containing Ligand: Cyclopentadienyldimethylsilane.
Authors: COLOMER E. , CORRIU R. J. P. , PLEIXATS R.
Published: May 2016

The dimethylsilylcyclopentadienide anion undergoes cleavage of the Si‐cyclopentadienyl bond on attempted complexation with transitions metals.
ChemInform Abstract: 7‐(Trifluoromethyl)‐1λ4,3λ4,5λ4‐trithia‐2,4,6,8,9‐pentaaza# bicyclo(3.3.1)nona‐1(9),2,3,5,7‐pentaene as Ligand in Coordination Chemistry.
Authors: MAGGIULLI R. , MEWS R. , STOHRER W.‐D. , NOLTEMEYER M.
Published: May 2016

Many possibilities exist for the title compound (I) to coordinate to transition‐metal centers.
ChemInform Abstract: Synthesis, Characterization and Cytotoxic Studies of Diamine and Diimine Palladium(II) Complexes of Diethyldithiocarbamate and Binding of These and Analogous Platinum(II) Complexes with DNA.
Authors: MITAL R. , JAIN N. , SRIVASTAVA T. S.
Published: May 2016

The three cationic Pd(II) complexes (III) are screened in vitro for antitumor activity against P 388 lymphocytic leukemic cells and show ID50 values lower than those of cisplatin.
Mind the gap: What is driving the survival disparity between the sexes in bladder cancer?
Authors: Harshman Lauren C.
Published: May 2016

Bladder cancer is well known to preferentially afflict men. However, women are significantly more likely to die of the disease even when corrected for stage, tumor characteristics, and age. In this issue of Cancer, Rose and colleagues highlight concerning disparities in bladder cancer treatment and outcomes between the sexes.

See also pages 2012–20.
PMH 9907: Long‐term outcomes of a randomized phase 3 study of short‐term bicalutamide hormone therapy and dose‐escalated external‐beam radiation therapy for localized prostate cancer
Authors: McPartlin Andrew J. , Glicksman Rachel , Pintilie Melania , Tsuji Debbie , Mok Gary , Bayley Andrew , Chung Peter , Bristow Robert G. , Gospodarowicz Mary K. , Catton Charles N. , Milosevic Michael , Warde Padraig R.
Published: May 2016

BACKGROUND

The role of hormone therapy (HT) with dose‐escalated external‐beam radiotherapy (DE‐EBRT) in the treatment of intermediate‐risk prostate cancer (IRPC) remains controversial. The authors report the long‐term outcome of a phase 3 study of DE‐EBRT with or without HT for patients with localized prostate cancer (LPC).

METHODS

From 1999 to 2006, 252 of an intended 338 patients with LPC were randomized to receive DE‐EBRT with or without 5 months of neoadjuvant and concurrent bicalutamide 150 mg once daily. The study was closed early because of contemporary concerns surrounding bicalutamide. The primary outcome was biochemical failure (BF) incidence, and the secondary endpoints were overall survival (OS), local control (LC), and quality of life. The BF and OS rates were estimated using the cumulative incidence function and Kaplan‐Meier methods and were compared using the Gray test and the log‐rank test.

RESULTS

Eleven patients were excluded from analysis. Characteristics were well balanced in each treatment arm. Ninety‐five percent of patients had IRPC. The prescribed dose increased from 75.6 grays (Gy) in 42 fractions to 78 Gy in 39 fractions over the period. At a median follow‐up of 9.1 years, 98 BFs occurred, with no significant effect of HT versus no HT on the BF rate (40% vs 47%; P = .32), the OS rate (82% vs 86%; P = .37), the LC rate (52% vs 48 %; P = .32) or quality of life, in the patients who completed the questionnaires. Dose escalation to 75.6 Gy versus >75.6 Gy reduced the BF rate by 26% (P = .004).

CONCLUSIONS

For patients who predominantly have IRPC, the addition of HT to DE‐EBRT did not significantly affect BF, OS, or LC. Bicalutamide appeared to be well tolerated. The conclusions from the study are limited by incomplete recruitment. Cancer 2016;122:2595–603. © 2016 American Cancer Society.
Use, complications, and costs of stereotactic body radiotherapy for localized prostate cancer
Authors: Halpern Joshua A. , Sedrakyan Art , Hsu Wei‐Chun , Mao Jialin , Daskivich Timothy J. , Nguyen Paul L. , Golden Encouse B. , Kang Josephine , Hu Jim C.
Published: May 2016

BACKGROUND

Stereotactic body radiotherapy (SBRT) for localized prostate cancer has potential advantages over traditional radiotherapies. Herein, the authors compared national trends in use, complications, and costs of SBRT with those of traditional radiotherapies.

METHODS

The authors identified men who underwent SBRT, intensity‐modulated radiotherapy (IMRT), brachytherapy, and proton beam therapy as primary treatment of prostate cancer between 2004 and 2011 from Surveillance, Epidemiology, and End Results Program (SEER)‐Medicare linked data. Temporal trend of therapy use was assessed using the Cochran‐Armitage test. Two‐year outcomes were compared using the chi‐square test. Median treatment costs were compared using the Kruskal‐Wallis test.

RESULTS

A total of 542 men received SBRT, 9647 received brachytherapy, 23,408 received IMRT, and 800 men were treated with proton beam therapy. There was a significant increase in the use of SBRT and proton beam therapy (P<.001), whereas brachytherapy use decreased (P<.001). A higher percentage of patients treated with SBRT and brachytherapy had low‐grade cancer (Gleason score ≤ 6 vs ≥ 7) compared with individuals treated with IMRT and proton beam therapy (54.0% and 64.2% vs 35.2% and 49.6%, respectively; P<.001). SBRT compared with brachytherapy and IMRT was associated with equivalent gastrointestinal toxicity but more erectile dysfunction at 2‐year follow‐up (P<.001). SBRT was associated with more urinary incontinence compared with IMRT and proton beam therapy but less compared with brachytherapy (P<.001, respectively). The median cost of SBRT was $27,145 compared with $17,183 for brachytherapy, $37,090 for IMRT, and $54,706 for proton beam therapy (P<.001).

CONCLUSIONS

The use of SBRT and proton beam therapy for localized prostate cancer has increased over time. Despite men of lower disease stage undergoing SBRT, SBRT was found to be associated with greater toxicity but lower health care costs compared with IMRT and proton beam therapy. Cancer 2016;122:2496–504. © 2016 American Cancer Society.
Epigenetic mechanisms and associated brain circuits in the regulation of positive emotions: A role for transposable elements
Authors: Gaudi Simona , Guffanti Guia , Fallon James , Macciardi Fabio
Published: May 2016

Epigenetic programming and reprogramming are at the heart of cellular differentiation and represent developmental and evolutionary mechanisms in both germline and somatic cell lines. Only about 2% of our genome is composed of protein‐coding genes, while the remaining 98%, once considered “junk” DNA, codes for regulatory/epigenetic elements that control how genes are expressed in different tissues and across time from conception to death. While we already know that epigenetic mechanisms are at play in cancer development and in regulating metabolism (cellular and whole body), the role of epigenetics in the developing prenatal and postnatal brain, and in maintaining a proper brain activity throughout the various stages of life, in addition to having played a critical role in human evolution, is a relatively new domain of knowledge. Here we present the current state‐of‐the‐art techniques and results of these studies within the domain of emotions, and then speculate on how genomic and epigenetic mechanisms can modify and potentially alter our emotional (limbic) brain and affect our social interactions. J. Comp. Neurol. 524:2944–2954, 2016. © 2016 Wiley Periodicals, Inc.