bluuebunny/crossref_metadata_2025 huggingface dataset:
The Adapted Autonomic Profile (Aap) Home-Based Test for the Evaluation of Neuro-Cardiovascular Autonomic Dysfunction
Authors: Sivan Manoj , Corrado Joanna , Mathias Christopher
Published: June 2022

Autonomic dysfunction is an increasingly recognised complication in chronic neurological conditions such as Parkinson’s disease , and other medical conditions, including diabetes mellitus, chronic fatigue syndrome, fibromyalgia and recently Long Covid. Despite laboratory-based tests to evaluate normal and abnormal autonomic function, there are no home-based tests to record neuro-cardiovascular autonomic responses to common stimuli in daily life that are dependent on the normal functioning of the autonomic nervous system. We have developed an adapted blood pressure/heart Autonomic Profile (aAP) that can be used by an individual independently and repeatedly in a domiciliary setting to determine the physiological and symptomatic response to standing, food, and physical and mental (cognitive, emotional) activities. The aAP aids separating autonomic failure (often irreversible) from autonomic dysfunction. This helps the individual understand the relationship between symptoms and common triggers in daily life, and informs on self-management in debilitating conditions such as postural tachycardia syndrome (PoTS) and Long Covid.
A Parametric Approach for Conceptual Integration and Performance Studies of Liquid Hydrogen Short-Medium Range Aircraft
Authors: Cipolla Vittorio , Zanetti Davide , Abu Salem Karim , Binante Vincenzo , Palaia Giuseppe
Published: June 2022

The present paper deals with the investigation, at conceptual level, of the performance of short-medium-range aircraft with hydrogen propulsion. The attention is focused on the relationship between figures of merit related to transport capability, such as passenger capacity and flight range, and the parameters which drive the design of liquid hydrogen tanks and their integration with a given aircraft geometry. The reference aircraft chosen for such purpose is a box-wing short-medium-range airplane, object of study within a previous European research project called PARSIFAL, capable to cut the fuel consumption per passenger-kilometre up to 22%. By adopting a retrofitting approach, non-integral pressure vessels are sized to fit into the fuselage of the reference aircraft, under the assumption that the main aerodynamic, flight mechanic and structural characteristics are not affected. A parametric model is introduced to generate a wide variety of fuselage-tank cross-section layouts, from a single tank with the maximum diameter compatible with a catwalk corridor to multiple tanks located in the cargo deck , and an assessment work-flow is implemented to perform the structural sizing of the tanks and analyse their thermodynamic behaviour during the mission. This latter is simulated with a time-marching approach that couples the fuel request from engines with the thermodynamics of the hydrogen in the tanks, which is constantly subject to evaporation and, depending on the internal pressure, vent-ed-out in gas form. Each model is presented in detail in the paper and results are provided through sensitivity analyses to both the technology parameters of the tanks and the geometric parameters influencing their integration. The guidelines resulting from the analyses indicate that light materials, such as the Aluminium alloy AA2219 for tanks’ structure and polystyrene foam for the insulation, should be selected. Preferred values are also indicted for the aspect ratios of the vessel components, i.e. central tube and endcaps, as well as suggestions for the integration layout to be adopted depending on the desired trade-off between passenger capacity, as for the case of multiple tanks in the cargo deck, and achievable flight ranges, as for the single tank in the section.
Assessing the Spatiotemporal Relationship between Coastal Habitats and Fish Assemblages at Two Neotropical Estuaries of the Mexican Pacific
Authors: Muro Victor , Amezcua Felipe , Ramírez-Ortiz Georgina , Flores-de-Santiago Francisco , Amezcua-Linares Felipe , Hernandez Yareli
Published: June 2022

Differences in fish assemblages’ structure and their relation with environmental variables (due to the variations in sampled seasons, habitats, and zones), were analyzed in two adjacent estuaries on the north Pacific coast of Mexico. Environmental variables and fish catches were registered monthly between August 2018 and October 2020. Multivariate analyses were conducted to define habitats and zones based on their environmental characteristics, and the effect of this variability on fish assemblages’ composition, biomass, and diversity (α and β) was evaluated. A total of 12,008 fish individuals of 143 species were collected using different fishing nets. Multivariate analyses indicated that fish assemblages’ structure was different between zones due to the presence, height, and coverage of distinct mangrove species. Additionally, factors such as depth and salinity showed effects on fish assemblages’ diversity (α and β-nestedness), which presented higher values in the ocean and remained similar in the rest of the analyzed zones and habitats. These results and the differences in species replacement (β-turnover) indicate the singularity of fish assemblages at estuaries (even in areas very close to the ocean), and the necessity to establish local management strategies for these ecosystems.
Traveling Wave Solutions of the Loaded Non-linear Klein-Gordon Equation via Functional Variable Method
Authors: Babajanov Bazar , Abdikarimov Fakhriddin
Published: June 2022

In this paper, the functional variable method is used to establish solitary wave solutions and periodic wave solutions of the loaded quadratic non-linear Klein-Gordon equation, the loaded cubic non-linear Klein-Gordon equation and the loaded coupled non-linear Klein-Gordon equation. All solutions of these equations have been examined and three dimensional graphics of the obtained solutions have been drawn by using the Matlab software. The main advantage of the proposed functional variable method over other methods is that it provides more new exact traveling wave solutions along with additional free parameters. The graphical representations of the soliton solutions and the periodic wave solutions by using distinct values of random parameter are demonstrated to better understand their physical features. The exact solutions have its great importance to reveal the internal mechanism of the physical phenomena.
The Effect of Planting Media and Axes on the Growth and Yield of Red Spinach (Amaranthus tricolor L.) in Hydroponic System
Authors: Vanesaputri Arki , Setiyono Setiyono , Arum Ayu Puspita
Published: June 2022

Hydroponics is a solution to a problem of lack of land that has an impact on cultivation of red spinach. Planting media and axes often used are rockwool and flannel. These materials have weaknesses which are expensive and difficult to find in some places. Yet, it can be overcomed by using local materials that have potentials to replace rockwool and flannel role. Therefore, it is necessary to investigate the effectiveness of the use of media types and axes. The research was conducted factorially using Split Plot Design with the archetype of group plot design (RAK) consisting of 2 factors with 3 repeats. The first factor as the main tile is type of media consisting of three levels; M1 (rockwool), M2 (cocopeat), and M3 (charcoal husk), while the second factor as sub plots are types of axes consisting of three levels; S1 (flannel), S2 (coconut coir fiber), and S3 (banana smelter fiber). The results showed that the interaction on types of media and axes had an unreally different influence on all observational variables except root volume variable; The types of media had an unreally different response to all observational variables; The types of axes had a different response which was not noticeable in plant height, root length, and header / root ratio, but It had a noticeable different response to variables in the number of leaves, root volume, fresh weight of the plant, and dry weight of the plant, in which S1 (flannel) showed the best results.
Preparation of Mg-Mn doped LiNiO2 via direct Indonesian Mixed Hydroxide Precipitate Lithiation
Authors: Rahmawati Mintarsih , Apriliyani Enni , Paramitha Tika , Gustiana Himmah Sekar Eka Ayu
Published: June 2022

Using local raw materials affects the development of the Li-ion batteries industry in Indonesia, which is highly important for the sustainability of electric vehicles. Cathode material affects around 40-50% of Li-ion batteries production costs. The utilization of cheap and local nickel sources for nickel rich-cathode material is a promising approach for reducing LIBs cell cost. Mixed Hydroxide Precipitate (MHP) which contain significantly high amount of nickel can serve as the nickel source for LiNiO2 cathode material This article proposes an effective and economical method to obtain nickel rich cathode material via direct high thermal lithiation of MHP. Non negligible amount of Mn and Mg in MHP can be directly used as a dopant. Based on XRD analysis, a mixture of NiO and LNO phase can be detected. The presence of Mg and Mn impurities is not observable. The SEM images confirms the irregular shape of the as-prepared LNO. The FTIR confirm the absence of residual Li. Based on the findings, a pretreatment technique is required to be explored in the future.
Supervisi Pengembangan Mutu Pendidikan: Tinjauan Konsep Developmental Supervision Glickman
Authors: Sonia Nur Rahmi
Published: June 2022

Currently, developmental models of supervision have dominated supervision thinking research throughout the world. But its importance were not well known by the implementer like supervisors and teachers and school principals particularly in developing countries. Therefore, this article aims to provide insight into understanding the essence of monitoring developments. The methodology or approach used in this paper uses a library research method or approach, while data collection is carried out by reviewing and/or exploring several journals, books, and documents (both printed and electronic) as well as data sources. and or other information deemed relevant to the study. The results of the study indicate that supervisors in carrying out have a collection of approaches in their implementation that adjust the characteristics of teachers appropriately. That way, the supervisor can determine a starting point for using supervisor orientation with individual teachers. Therefore, developmental supervision is based on three broad propositions, namely, first, based on varying backgrounds and experiences, teachers operate at different levels of professional development. Second, the ability and effectiveness of teachers are also different, so they need to be improved in different ways. Third, the long-term goal of supervision must be to increase the ability of every teacher and school to grow to a higher stage.
Measuring the Efficiency of the Healthcare System with a Focus on Pilot Case Study
Authors: rouyendegh babak , Dag Ali , Taspinar Asli Z. , Pınar Adem
Published: June 2022

The present study examines the efficiency of the healthcare system in Turkey by focusing on one hospital situated in Ankara. TOPSIS-DEA methodology was adopted for this purpose to determine and compare the efficiency of hospital units while assigning different weights to individual types of data and relying on q-rung TOPSIS to handle uncertainty. The outcome is a set of rankings assigned to individual hospital units, thus informing the decision-makers of the strategies that should be adopted to improve hospital functioning.
Strengthening contributions of mechanical twinning and dislocations to the flow stress of 1.1C-12.5Mn steel at a strain rate of unity per second: Quantitative analysis
Authors: Khedr Mahmoud , Li Wei , Min Na , Abd-Elaziem Walaa , Jin Xuejun
Published: June 2022

The flow stress of high C-Mn austenitic steel is attributed to lattice friction, dynamic strain aging (DSA), mechanical twinning and forest hardening. However, it has not been clarified yet which mechanism quantitatively contributes most to the work hardening of 12.5Mn-1.1C steel. In this study, austenitic Hadfield steel (1.1 wt.% C and 12.5 wt.% Mn) was tensile tested at a strain rate of 10⁰ s− 1. The lattice friction was estimated by the Hall-Petch relationship. DSA effect was neglected because of the high strain rate of deformation. Twin plates characteristics and dislocation densities were estimated quantitatively at different strain levels (11, 18, 25, 38, and 55%). The deformed twin plates were studied by optical and transmission electron microscopies. Dislocation densities were estimated by analyzing the X-ray diffraction patterns using Rietveld analyses. A linear approach was utilized to model the flow stress during the plastic deformation, and it is found that the linear model is consistent with the experimental results. During the early stages of the plastic deformation, the mechanical twinning was the dominant deformation mechanism, and it was more effective to the flow stress than the forest hardening due to the enhancement of the twin nucleation process. However, with increasing the strain level, the thicknesses of the twinned plates were increased rather than the initiation of new twin plates, resulting in a reduced contribution by the mechanical twinning to the flow stress. On the other hand, increasing the dislocation densities with an increase in the strain level was detected, which resulted in an enhanced contribution by forest hardening to the flow stress more than the mechanical twinning.
Sliding Mode Control based MPPT and Output Voltage Regulation of a Two-stage Stand-alone PV System
Authors: Manuel Nelson Luis , İnanç Nihat
Published: June 2022

When it comes to reducing emissions caused by the generation of electricity through conventional sources, among different renewable energies, the solar gains prominence, due to its geographical availability, simplicity of implementation and absence of moving parts. However, the performance of photovoltaic systems is dependent on environmental conditions. Depending on temperature and solar irradiation, the PV system has an operating point where maximum power can be generated. The techniques that are implemented to find this operating point are the so-called maximum power point tracking (MPPT) algorithms. Since weather conditions are variable in nature, the output voltage of the PV system needs to be regulated to remain equal to the reference. Most of the existing studies focus either on MPPT or on voltage regulation of the PV system. In this paper, the two-stage PV system is implemented so that both MPPT and voltage regulation are achieved simultaneously. Additionally, an improved version of the Perturb and Observe (P&O) algorithm based on artificial potential fields (APF), called APF-P&O, is proposed. Sliding Mode Controllers with appropriate control laws are designed for both stages of conversion. Simulations performed in MATLAB/Simulink software prove the superiority of the proposed APF-P&O method over the conventional P&O method in terms of convergence time, output power ripples and sensitivity to step sizes. At the same time, the voltage regulation issue is also solved, where the output voltage is fixed to the value of 32 V, regardless of variations in solar irradiation.
Sixth-week immune-nutritional-inflammatory biomarkers: Can they predict clinical outcomes in patients with lung cancer treated with immune checkpoint inhibitors?
Authors: olgun polat , diker omer
Published: June 2022

We explored the relationship between inflammatory markers such as the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), Lung Immune Prognostic Index (LIPI), and the modified Glasgow Prognostic Score (mGPS) to determine whether they could predict treatment response to pembrolizumab or nivolumab (immunotherapy).We included all patients with lung cancer who were treated with immune checkpoint inhibitors (ICIs) from 2017-2021. We examined NLR, PLR LIPI, and mGPS trends and explored the association with progression-free survival (PFS) overall survival (OS), and response rates (RR) at 6 weeks. Eighty-three patients were enrolled in the study. The presence of liver metastasis, low post-treatment NLR (<5), low post-treatment PLR (<170), intermediate post-treatment LIPI and immune-related adverse events were significantly associated with response. Multivariate analysis demonstrated that high post-treatment NLR(≥5) and PLR(≥170) was an independent prognostic factor of shorter OS. A good LIPI status was associated with better PFS and OS in ICI therapy compared with intermediate or poor LIPI status. Post-treatment mGPS independently predicted anti-PD1 treatment efficacy; a good post-treatment mGPS (GPS 0-2) was significantly associated with improved PFS and OS .Posttreatment NLR, PLR, LIPI, and mGPS are associated with worse OS and recurrence. These findings should be validated independently and prospectively in further studies.
Comparing ‘clinical hunch’ against clinical decision support systems (PERC Rule, Wells score, revised Geneva score and YEARS criteria) in the diagnosis of acute pulmonary embolism.
Authors: Medson Koshiar , Yu Jimmy , Liwenborg Lovisa , Lindholm Peter , Westerlund Eli
Published: June 2022

Background:Pulmonary embolism (PE) is a common and potentially life-threatening condition. Since it is considered a ‘do not miss’ diagnosis, PE tends to be over-investigated beyond the evidence-based clinical decision support systems (CDSS), which in turn subjects patients to unnecessary radiation and contrast agent exposure with no apparent benefits in terms of outcome.The purpose of this study was to evaluate the yield of ‘clinical hunch’ (gestalt) and four CDSS: the PERC Rule, Wells score, revised Geneva score, and Years criteria. Methods:A review was conducted on the Electronic Medical Records (EMR) of 1,566 patients from the Emergency Department at a tertiary teaching hospital who underwent CTPA from 1st of January 2018 to the 31st of December 2019. The scores for the four CDSS were calculated retrospectively from the EMR data. We considered that a CTPA had been ordered on a clinical hunch when there was no mention of CDSS in the EMR, and no D-dimer test. A bypass of CDSS was confirmed when any step of the diagnostic algorithms was not followed.Results:Of the total 1,566 patients who underwent CTPA, 265 (17%) were positive for PE. The diagnosis yield from the five decision groups (clinical hunch and four CDSS) was as follows - clinical hunch, 15%; PERC rule, 22% (7% when bypassed); Wells score, 19% (11% when bypassed); revised Geneva score, 26% (15% when bypassed); and YEARS criteria, 18% (6% when bypassed).Conclusion:Clinicians should trust the evidence-based clinical decision support systems in line with the international guidelines to diagnose PE.
The role of the NEK10/ERK1/2 signaling pathway in the albumin overload-induced G2/M phase block in renal tubular epithelial cells
Authors: Liu Limin , Jia Rui , He Zhixiong , Zhang Lizi , Lv Zijian , Tai Fadao
Published: June 2022

Background
G2/M phase arrest in tubule epithelial cells during acute kidney injury (AKI) is closely associated with renal fibrosis. As the the main components of the kidney, the renal tubules are susceptible to multiple injuries such as ischemia, toxins, proteinuria as well as metabolic disorders. Proteinuria, as a marker to detect renal disease, is an independent risk factor for the injury of renal tubular epithelial cell and tubulointerstitial due to its potential to aggravate kidney. However, the pathway of urinary protein aggravates renal tubular injury remains controversial.
Methods
In this study, we explored the connection between proteinuria and renal tubular injury as well as the internal mechanism. Herein, the human proximal tubule kidney cell line HK2 was treated with different concentrations of albumin.
Results
The results of RT-qPCR and western-blot suggested that the level of renal injury worsened with the increasing albumin concentrations (p < 0.05). Consistent with the extent of the damage, the NEK10/ERK1/2 signaling pathway was activated to different degrees (p < 0.05). The flow cytometry results suggested that albumin overload induced G2/M phase blockade in renal tubular epithelial cells, which was directly connected to the NEK10/ERK1/2 signaling pathway. In addition, clinical puncture specimens of the kidney also verified this conclusion.
Conclusion
This study demonstrated that albumin could result in damage to HK cells and G2/M cell cycle arrest in vitro and kidney injury in vivo through the activation of NEK10/ERK1/2 pathway. The results indicates that therapeutic strategies targeting NEK10/ERK1/2 pathway may provide an effective strategy in the clinical management of proteinuria-related renal fibrosis.
Temporal and spatial evolution of Cabeza de Vaca 2021 rift eruption
(Cumbre Vieja volcano, La Palma, Canary Islands) from
geophysical and geodesic paramethers analyses
Authors: Oterino Belén Benito , Alvarado Guillermo , Marchamalo Miguel , Rejas Juan Gregorio , Murphy Patrick , Franco Rebeca , Castro Diego , GAcia-Lanchares Carlos , SAnchez JAime
Published: June 2022

The Cabeza de Vaca eruption is the most recent, damaging, and long-term eruption since historical records at La Palma. We analyzed geophysical parameters (seismicity, surface deformation, thermal anomalies, volcanic activity) with the aim to reconstruct the temporal development of the magma plumbing system. The seismic sequence (>9000 events, mbLg ≤5.0) can be grouped into nine distinct phases, which correspond to well-separated spatial clusters and distinct earthquake regimes. A strong premonitory thermal anomaly was calculated on July 2021 at the South of La Palma. The source of the magmas (40-20 km depth) storage withing the upper mantle. The second source (<15 km depth) indicated a short-term stagnation of alkaline magma within the lower crust, near the Moho. These earthquakes outline delineating the magma pathway. Just before and immediately after the eruption (phases 2 and 3), the high-frequency seismicity in the mantle disappears completely, reappearing ten days after the eruption started. The pattern of deformation began before the eruption with a breakpoint around September 11, after which, deformation accelerated sharply followed by a stabilization in phase 3 and a decrease in following phases. The level of deformation suggested that a shallow magma intrusion was stablished. Based in the historical eruptive pattern, it could be dilucidated that: a) the volcano could enter in a prolonged phase of tranquility or, b) that a new eruption occurs between ca . 2045 and 2065 with a duration slightly lower than the recent one. Therefore, assuming a pessimistic scenario, an adequate territorial planning is meritorious.
Energy Harvesting System Design and Optimization Using High Bandwidth Rectenna for CUBESAT used in Asteroid Detection
Authors: Marriwala Nikhil , B Debarpita
Published: June 2022

The aim of this paper is to structure a compact size rectenna for cubeSat applications for asteroid detection. The scale of the antenna is to kept as small as possible 18 X 10 mm. The antenna designed here is probably going to own its applications in satellite communication system. The antenna designed in this project is structured in such a way that it is covering a good wide range of frequency from X-band to K-band.The aim of this paper is to design a cubesat rectenna which will not only make cubesat cost effective but also lighter weight with RF to DC power conversion which will reduce use of solar panels, solar cells or solar array. At first antenna is designed in HFSS keeping its size in mind and simulated than rectifier is designed in MATLAB Simulink and antenna is interfaced with it for conversion process. Rectenna design converts 2.85963102361 watt power to 14.62 watt power for 9 GHz and 3.19124391714 watts to 16.48 watts using a voltage multiplier circuit. Also, two way transmissions by antenna is shown uplink frequency of 18.6 GHz-18.8GHz and downlink frequency of 8.45GHz-8.5GHz.The antenna shown RF output power of 2.85963102361 Watts and in terms of dBW it is 4.5631dBW at 9 GHz and of 3.19124391714 watts and in terms of dBW it is 5.0396dBW at 19 GHz.Return loss for satellite must be less than − 10dB and in this designed this objective is also achieved. DC power in the range of 5–20 Watt is required for desired cubesat mission and as mentioned it generates power of 14.62 watts and 16.48 watts.The main aim of this rectenna is to create a cubesat system suitable for planet defense from asteroid. In this work various parameters like Return loss, Gain, Radiation pattern, rectifier design and dc power generated are also discussed.
Graph Convolution Network for Social Recommendation
Authors: Zhang Yuanyuan , Shi Xinchen , Zhang Yonglong , Zhu Junwu
Published: June 2022

In recent years, due to the characteristics of graph convolutional networks (GCN) that can effectively integrate node information and topological structure, they have shown strong capabilities in graph data representation learning. Since the data in the social recommender systems exists in a graph structure, these characteristics of GNN greatly promote the development of social recommendation. However, the construction of GCN-based social recommender systems faces the following challenges: (1) Users exist in both user-item interaction graphs and social relationship graph, and items exist in both user-item interaction graphs and item collaborative similarity graphs; (2) There is high-order connectivity of the user-user social relationship and the item-item collaborative similar relationship; (3) The embeddings of users and items come from different two graphs have different semantic contributions. In order to solve the above three challenges simultaneously, this paper proposes G raph C onvolution Network for S ocial R ecommendation (GCSR), which models the user-item interaction network, social network and item collaborative similar network into a unified network. Specifically, we provide a principled method to explicitly capture the high-order connectivity of user-items to improve embedding. In addition, the gating mechanism is used for feature fusion to model heterogeneous strengths. A large number of experiments on two real datasets prove the effectiveness of the proposed framework GCSR.
HPTLC Fingerprinting Reveals Leaf and Roots Phytochemical Variability in Developmental stages of Withania somnifera
Authors: Lingfa Lali , Gugulothu Baloji , Jagtap Sandhya , Ankanagari Srinivas
Published: June 2022

Background
Withania somnifera has been the foundation of numerous contemporary medicines today for treatment of various diseases. However, phytochemical variability profile is lacking in the root and leaf organs.
Aim
This study was aimed to elucidate the phytochemical profile in seedling, vegetative and reproductive stages of leaf and roots in W. somnifera using High performance thin layer chromatography (HPTLC) fingerprinting.
Methods
The HPTLC with dual wavelength UV (254/366 nm) was used for the analysis of phytochemical variation in leaf and root methanolic extracts of W. somnifera.
Results
HPTLC chromatograms in 366 nm, 254 nm, and normal day light, seedling, vegetative and reproductive stages leaf and root exhibited bands variability. At 450 nm leaf HPTLC fingerprints in seedling stage showed five peaks with Rf values in the range of 0.42 to 0.90, vegetative stage with nine peaks of Rf values in range of 0.10 to 0.89, and reproductive stage with six peaks of Rf values in range of 0.30 to 0.92. In root showed six peaks with Rf values in range of 0.00 to 0.82 in seedling stage, ten peaks with Rf values in range of 0.00 to 0.96 in vegetative stage, seven peaks with Rf values in range of 0.01 to 0.91 in reproductive stage. In roots, higher peak areas were found at the reproductive stage (3.33%) compared to vegetative stage (1.65%).
Conclusion
The comparative HPTLC fingerprints of leaves and roots in W. somnifera presented phytochemical variability in leaf and root that varied with developmental stages.
Performance Analysis of NOMA Integrated Hybrid Satellite Terrestrial Communication System using ML
Authors: Prasad Priyanka , MK Arti , Jain Aarti
Published: June 2022

The Non Orthogonal Multiple Access (NOMA) is a promising technology for future communication system due to its ability to offer services to multiple users with better connectivity and low latency. The NOMA based Cooperative Relay System (NOMA-CRS) is used to improve the spectral efficiency as compared to conventional Cooperative Relay System (CRS). In this paper, the performance of NOMA over hybrid satellite terrestrial communication system is analyzed over two different fading channels- Shadowed Rician fading channel and Nakagami-m fading channel in two phases of downlink transmission and also derived the expression for end to end Bit Error Rate of proposed model assisted with cooperative relays. The results have shown significant performance with variations in the derived parameters and validated in extensive simulations.
Ranking of Empirical Evapotranspiration Models in Different Climate Zones of Pakistan
Authors: Hamed Mohammed Magdy , Khan Najeebullah , Shahid Shamsuddin , Muhammad Mohd Khairul Idlan
Published: June 2022

Accurate estimation of evapotranspiration (ET) is vital for water resources development, planning and management, particularly in the present global warming context. A large number of empirical ET models have been developed for estimating ET. The main limitations of this method are that it requires several meteorological variables and an extensive data span to comprehend the ET pattern accurately, which is not available in most developing countries. The efficiency of 30 empirical ET models has been evaluated in this study to rank them for Pakistan to facilitate the selection of suitable models according to the availability of data. Princeton Global Meteorological Forcing daily climate data with a 0.25°×0.25° resolution for 1948–2016 was utilized. The ET estimated using Penman-Monteith (PM) was considered as the reference. Multi-criteria group decision-making (MCGDM) was used for the ranking of the models for Pakistan. The results showed the temperature-based Hamon as the best model for most Pakistan, followed by Hargreaves-Samani and Penman models. Hamon also showed the best performance in terms of different statistical metrics used in the study with a mean bias (PBias) of -50.2%, mean error (ME) of -1.62 mm and correlation coefficient (R2) of 0.65. Ivan showed the best performance among the humidity-based models, Irmak-RS and Ritch among the radiation-based models and Penman among the mass transfer-based models. Northern Pakistan was the most heterogeneous region in the relative performance of different ET models.
Gestational bisphenol A exposure impacts hepatic lipid metabolism in male offspring rats by regulating mTOR/CRTC2/SREBP1
Authors: Yang Qiaoqiao , Mao Yaping , Wang Juan , Yu Haiyang , Zhang Xuan , Pei Xiucong , Duan Zhiwen , Xiao Chunling , Ma Mingyue
Published: June 2022

Lipid metabolism is an important biochemical process in the body. Recent studies have found that environmental endocrine disruptors play an important role in the regulation of lipid metabolism. Bisphenol A (BPA), a common environmental endocrine disruptor, has adverse effects on lipid metabolism, but the mechanism is still unclear. This study aimed to investigate the effects of gestational BPA exposure on hepatic lipid metabolism and its possible mechanism in male offspring. The pregnant Sprague-Dawley rats were exposed to BPA (0, 0.05, 0.5, 5 mg/kg/day) from day 5 to day 19 of gestation to investigate the level of triglyceride (TG) and the expression of liver lipid metabolism-related genes in male offspring rats. The results showed that compared with the control group, the TG level in serum and liver in BPA-exposed groups was increased. And the expressions of liver fatty acid oxidation related genes, such as peroxisome proliferators-activated receptor α (PPARα) and carnitine palmitoyl transferase 1α (CPT1α), were down-regulated. However, the expressions of fatty acid synthesis related genes, such as sterol regulatory element binding proteins 1 (SREBP-1), acetyl-CoA carboxylase 1 (ACC1), fatty acid synthase (FAS) and stearoyl-CoA desaturase 1 (SCD-1), were up-regulated. The increased protein levels of mTOR and p-CRTC2 suggested that CREB-regulated transcription coactivator 2 (CRTC2) might be an important mediator in the mTOR/SREBP-1 pathway. In conclusion, these results demonstrated that mTOR/CRTC2/SREBP-1 could be affected by gestational BPA exposure, which may involve in the lipid metabolic disorders in later life.
A Quasi Variational-Hemivariational Inequality for Incompressible Navier-Stokes System with Bingham Fluid
Authors: Dudek Sylwia , Migorski Stanislaw
Published: June 2022

In this paper we examine a class of elliptic quasi-variational inequalities which involve a constraint set and a set-valued map. First, we establish existence of solution and the compactness of the solution set. The approach is based on results for an elliptic variational inequality and the Kakutani-Ky Fan fixed point theorem. Next, we prove an existence and compactness result for a quasi variational-hemivariational inequality. The latter involves a locally Lipschitz functional and a convex potential. Finally, we present an application to the stationary incompressible Navier-Stokes equation with mixed boundary conditions which model a generalized Newtonian fluid of Bingham type.2020 Mathematics Subject Classification. 35J87, 49J40, 76A05.
Development and Analysis of Human Hair Fiber and Chicken Feathers Reinforced Composite
Authors: Worku Tesfaye , Nachippian Sukumar
Published: June 2022

In the current year, composites have been concerned with considerable importance as a potential operational material. Many works have been carried out to enhance the mechanical properties of composites. Chicken feather, human hair and hairs of other birds and animals are commonly described as a waste product. Currently, available disposal methods such as burying and burning of these waste by-products are contributing to environmental pollution. In this research work composite was developed using human hair & chicken feather fiber and analysis the mechanical and physical property of the developed composite sample. Four different composition ratio composite samples were fabricated and then physical and mechanical properties were tested according to standards. Both flexural and compressional strength increase for the first two composite samples, then after it shows a gradual decrease when we have increased the fiber content and decreased resin and sample show that the amount of water absorption in percentage increases when the fiber content increases, and the matrix material (polyester resin) decrease. This research study indicates that using human hair and chicken feather fibers as reinforcement in a polymer matrix could successfully develop a composite material in terms of high strength and rigidity for lightweight house ceiling board material.
Give the nose some credit: rationale for a need to include scent training in medical education
Authors: Liao En-Dien , Majdinasab Elleana Joy , Le Christopher Q , Ramesh Malvika , Satheeshkumar Anu , Ganapathy Vadivel
Published: June 2022

Medical education largely overlooks the sense of smell in clinical training notwithstanding clear evidence that several diseases carry with them pathognomonic scents that can serve as diagnostic clues. We report here an observational cross-sectional study in which we assessed students’ attitudes toward the utility of scent in the process of medical diagnosis as well as their competence and confidence in being able to apply recognition of odor to specific diseases in the clinical setting. We found that nearly 90% of medical students felt that formal incorporation of scent in their medical training would make them more competent physicians. However, approximately 80% of them did not feel confident using scent as a diagnostic aid. Currently, there is a lack of emphasis on the usefulness of the sense of smell in modern medical education, and in the study reported here, we consider the rationale for possible inclusion of olfactory exposure in clinical training.
Exploring B2B Chatbots adoption experiences: Lessons for successful implementation in Businesses
Authors: kaushal vaishali , Yadav Rajan
Published: June 2022

Artificial Intelligence empowered Chatbots are altering the nature of service interfaces which has further resulted in raised expectations from Chatbots to understand customer’s social interactions and respond them within the turnaround time. To close this research gap, we conduct an exploratory study in two phases-Industry’s perspective and B2B customer’s perspective and analyse results with the help of NVIVO 12 plus and Leximancer. The findings reveal perceived risk with respect to Chatbots is high, complex pricing structure along with non-availability of testing options makes the pre purchase more complex. Moreover, interactive speed, Customization especially with respect to language issues, Integration with other platforms is some of the major themes which influence Customer Experience. Advancements in AI, natural Language processing (NLP) and more testing at all phases will bring efficiency, automation first strategies. Our findings suggest Chatbots must provide a more personalized, scalable and omni channel engagement and focus on delivering more enhanced customer experience. Chatbots must offer a grievance management dashboard where the customer can see live queries, resolved queries, present queries status etc to get transparency. Chatbots streamline the lead qualification process, greatly improve, and speed up the data collection therefore, enhancing customer experience.
Towards Uncertainty in Decision: A Survey on Recent Advances and Challenges in Bayesian Reinforcement Learning
Authors: Wang Zicheng , Meng Hua , Zhou Zhengchun , Feng Yanghe , Gao Yang , Yu Chao
Published: June 2022

Reinforcement learning is a research paradigm that is commonly utilized to tackle problems involving sequential decision-making. Agents learn optimum policy from samples generated by interacting with uncertain environments. Bayesian reinforcement learning presents the uncertainty measure of probability significance based on sequential decision-making, which plays a proper auxiliary function in the optimization of agent control policies, attracting a lot of study attention. This paper provides an overview of contemporary Bayesian and reinforcement learning methods in this setting. We begin by outlining the many types of reinforcement learning and Bayesian approaches, as well as their characteristics. Then we review the most sophisticated Bayesian reinforcement learning approaches from the perspective of uncertainty measurement and control, as well as summarize and discuss various challenges and related research in its expansion to complicated control tasks. Applying the Bayesian technique with reinforcement learning in diverse disciplines are then discussed. Finally, we highlight the current challenges of Bayesian reinforcement learning and future research topics that might help promote Bayesian reinforcement learning.
Etiology analysis for full-term newborns with severe hyperbilirubinemia in eastern Guangdong
Authors: Xu Jia-Xin , Lin Fen , Wu Yong-Hao , Ma Yu-Bin , Yang Li-Ye
Published: June 2022

Objective
To explore the etiological characteristics of severe hyperbilirubinemia in full-term newborns of eastern Guangdong.
Methods
Full-term newborns with severe hyperbilirubinemia in one hospital from January 2012 to December 2021 were retrospectively analyzed. The etiology was determined according to the laboratory results and clinical manifestations.
Results
Among 1602 full-term newborns with hyperbilirubinemia in Chaozhou area, 32.20% (580/1602) was severe hyperbilirubinemia, including 213 newborns with TSB levels reaching the recommended exchange transfusion levels and 52 cases diagnosed with prolonged jaundice. Among the causes of severe hyperbilirubinemia, neonatal hemolysis accounted for 15.17%, infection accounted for 10.17%, G6PD deficiency accounted for 9.13%, and the coexistence of multiple etiologies accounted for 6.55%, unknown etiology accounted for 50.00%. ABO hemolysis and G6PD deficiency were the most common causes in the 20 cases with bilirubin encephalopathy. 94 severe hyperbilirubinemia newborns were tested for UGT1A1*6 variant (rs4148323, c.211G > A, p.Arg71Gly,), 9 cases were 211 G to A homozygous variant, 37 cases were 211 G to A heterozygous variant, and 48 cases were wild genotypes.
Conclusion
The main cause for severe hyperbilirubinemia and bilirubin encephalopathy were the hemolytic disease of the newborn, G6PD deficiency and infection. UGT1A1 gene variant was also a high risk factor for neonatal hyperbilirubinemia. Targeted prevention and treatment according to the etiology may reduce the occurrence of bilirubin encephalopathy and kernicterus.
Volkan Patlamalarının Coğrafi Bilgi Sistemleri ve Uzaktan Algılama Yöntemleri ile İzlenmesi: Cumbre Vieja Volkanı (İspanya) Örneği
Authors: AKYÜREK Özer
Published: June 2022

Doğal afetler insanlar için çeşitli kayıplar oluşturan, hayatı kesintiye uğratarak tüm canlıları etkileyen olaylar olarak tanımlanmaktadır. Volkanlar, yerkürenin var oluşundan günümüze kadar geçen süre içerisinde, doğal yaşamı çeşitli açılardan etkilemişlerdir. Çeşitli açılardan yararları olduğu gibi (ısınma-jeotermal sular vb.), zararları da olmuştur. Doğal afetlerden bir tanesi olan volkanik patlamalar insanlık tarihi boyunca birçok yıkıma ve ölüme neden olmuştur ve olmaya devam etmektedir. Günümüz teknolojisinde volkanik afetlerin izlenmesinde Coğrafi Bilgi Sistemleri ve Uzaktan Algılama araçları, yönetim ve takibin ayrılmaz birer parçası olarak kullanılmaktadırlar. CBS ve Uzaktan Algılama, modern ve kullanışlı bir veri toplama ve işleme, analiz etme, sorgulama ve güncelleme araçları olarak kullanılmaktadırlar. Bu çalışmada 19 Eylül - 15 Kasım 2021 arasında geçen süre içerisinde Pleaides-1A, CosmoSky Med-radar, GeoEye-1 ve Landsat 8 verileri kullanılarak La Palma adasındaki Cumbre Vieja volkanından çıkan lavların adada yaşayan insanlara, yapılara ve arazi örtüsüne etkileri incelenmesi amaçlanmıştır. Volkandan çıkan lavların 1,042.07 hektarlık alana yayıldığı belirlenmiştir. Bu alan içerisinde 2,749 adet binanın tamamen yıkılmış veya kısmen hasar gördüğü yapılan analizlerde ortaya çıkarılmıştır. Zarar gören ulaşım hatlarının uzunluğu ise 80.1 km’ye ulaşmıştır. Yer yüzey sıcaklığı analizi ile bölgenin patlama öncesi ve sonrasına ait sıcaklık değişimi incelenmiştir. Yapılan CBS ve UA analizleri sonucunda çeşitli tarım alanları ve ormanlık alanlar ile birlikte yerleşim alanları ve okyanusun da zarar gördüğü saptanmıştır.
Management of biological waste of patients after radionuclide therapy
Authors: Chipiga L. A. , Vodovatov A. V. , Zvonova I. A. , Stanzhevsky A. A. , Petryakova A. V. , Anokina E. E. , Velichkina K. S. , Ryzhov S. A.
Published: June 2022

Radioactive waste management is a modern-day issue in terms of radiation safety due to the development of radionuclide therapy, the emergence of new radiopharmaceuticals, radionuclides, and treatment methods, which allow for radionuclide therapy in a day hospital. According to the current domestic regulatory and methodological support biological wastes generated during the patient’s metabolic activity after injection of the radiopharmaceuticals for the therapy refer to the liquid radioactive waste. These wastes must be collected and kept for decay in hospitals to the safe levels before being spilled into the municipal sewerage. It requires additional expenses to the hospital for making the special sewerage. To increase the availability of radionuclide therapy, it is necessary to update the requirements of the liquid radioactive waste management in nuclear medicine departments, considering the volume activities of different diagnostic and therapeutic radionuclides in wastes generated after the injection of radiopharmaceuticals to the patients. On the basis of findings, it is possible to evaluate the feasibility of the binding requirement for the availability of special sewerage in the departments of the radionuclide therapy. In this work, excretion of the radiopharmaceuticals used in therapy:89Sr-dichloride,223Ra-dichloride,131I-MIBG,177Lu-PSMA, and225Ac-PSMA was studied based on published data to determine the activity levels of radionuclides in waste of patients. As a results of preliminary computations, some nuclear medicine procedure will not lead to generation of liquid radioactive waste from biological waste of patients in sewerage system in usual operating condition and special sewerage is not strictly necessary. For example, estimations of radionuclide activity in wastes showed the volume of current sewerage system in a small hospital with a limitation of 50 beds can be enough to reduce the level of specific activity of radionuclides in wastewater from one patient a day after radionuclide therapy with89Sr-chloride and223Ra-dichloride. In order to revision of requirements to special sewerage in each department of radionuclide therapy and to development of differentiated approach to the management of biological waste of patient in nuclear medicine departments, which ensure environment protection and radiation safety of people, it is necessary to continue the research including development and modeling of realistic scenario of staff and patient radiation exposure confirmed experimental results.
KÜLTÜREL YETKİNLİK KENDİNİ DEĞERLENDİRME ÖLÇEĞİ: TÜRKÇEYE UYARLANMASI, GEÇERLİK VE GÜVENİRLİK ÇALIŞMASI
Authors: UZUNASLAN Şerif , GÖKÇEARSLAN ÇİFCİ Elif
Published: June 2022

Bu çalışmada, Leung ve Cheung (2013) tarafından geliştirilen “ASK Cultural Competency Self-Assessment Scale” adlı ölçek, ölçeğin geliştiricilerinden gerekli izinler alınarak Türkçeye uyarlanmıştır. Çalışma grubunu sosyal hizmet alanında aktif olarak çalışan 246 sosyal hizmet uzmanı oluşturmaktadır. İç tutarlılık katsayısı (Cronbach’s alpha) ölçek bütünü için 0,952; tutum değerlendirme boyutu için 0,875; beceri değerlendirme boyutu için 0,864 ve bilgi değerlendirme boyutu için 0,926 olarak hesaplanmıştır. Güvenirlik işlemlerini sağlamak amacıyla %27’lik alt ve üst gruplar arasındaki farklar incelenmiştir. Yapılan çözümlemede (t (130):21,93, p
TEK EBEVEYN OLAN ANNELERİN BİLİŞSEL ESNEKLİKLERİ VE YAŞAM DOYUMLARI ARASINDAKİ İLİŞKİ: PSİKOLOJİK SAĞLAMLIĞIN ARACI ROLÜ
Authors: ODACI Hatice , ÜLKEN Emine , BÜLBÜL Kenan
Published: June 2022

Günümüzde sayıları giderek artmakta olan tek ebeveynli aileler genellikle anne ve çocuklarından oluşmaktadır. Bu çalışmada tek ebeveyn olan annelerin bilişsel esnekliği ile yaşam doyumu arasındaki ilişkide psikolojik sağlamlığın aracı rolünün değerlendirilmesi amaçlanmıştır. Ayrıca tek ebeveyn annelerin bilişsel esneklikleri, psikolojik sağlamlıkları ve yaşam doyumları; eğitim düzeyi, çalışma durumu, gelir düzeyi, psikolojik destek alma, psikiyatrik ilaç kullanma ve tek ebeveyn olma nedenine göre incelenmiştir. Çalışmada Kişisel Bilgi Formu, Kısa Psikolojik Sağlamlık Ölçeği, Yetişkin Yaşam Doyumu Ölçeği ve Bilişsel Esneklik Envanteri kullanılmıştır. Bu çalışma, yaşları 21 ile 75 arasında değişen ve yaşları ortalaması 41.97 (SS= 9.40) olan 265 tek ebeveyn olarak çocuklarıyla yaşamlarını sürdürmekte olan annelerle yürütülmüştür. Veriler SPSS 24.0 programı ve PROCESS eklentisi ile analiz edilmiştir. Yapılan analizler sonucunda, bilişsel esneklik, yaşam doyumu ve psikolojik sağlamlık arasında anlamlı pozitif ilişkilerin olduğu; bilişsel esneklik ile yaşam doyumu arasındaki ilişkide psikolojik sağlamlığın kısmi aracı rol üstlendiği gözlenmiştir. Bilişsel esnekliğin çalışma durumu, gelir düzeyi ve psikiyatrik ilaç kullanımı durumuna göre; psikolojik sağlamlığın çalışma durumu, gelir düzeyi, psikolojik destek alma ve psikiyatrik ilaç kullanma durumuna göre; yaşam doyumunun eğitim durumu, çalışma durumu ve gelir düzeyine göre anlamlı olarak farklılaştığı bulgulanmıştır.