bluuebunny/crossref_metadata_2025 huggingface dataset:
Estación terrena satelital
Authors: Espindola Diaz Jorge Enrique , Rosales Agredo Jenny Amparo , Nonsoque Quintero Carlos Augusto
Published: November 2023

El libro Estación Terrena Satelital - Rastreo y Control de Pequeños Satélites,  muestra la metodología para diseñar e implementar una estación terrena que tiene como objetivo controlar y rastrear satélites ubicados en órbita LEO.  Como resultado de investigación, en este documento se encuentran los objetivos planteados, la problemática, la metodología desarrollada y los resultados obtenidos.  De igual forma, la UPTC, con esta estación permite que la comunidad científica especialmente la de Colombia, pueda replicar el montaje de una estación terrena con fines académicos.  La estación está ubicada en la ciudad de Tunja, Boyacá, y usa bandas libres para el enlace satelital en frecuencia de 144 MHs en VHF y 440 MHz en UHF.
Guía para la caracterización de prestadores de servicios turísticos
Authors: Granados Ramiro Hernando , Suárez Salazar José Fabián
Published: November 2023

Como aporte al desarrollo de la actividad turística desde la academia y atendiendo a las necesidades que presenta el sector turístico en aspectos de planificación y gestión de la actividad, presentamos este valioso insumo como herramienta de sistematización de información respecto al estado real de la oferta turística desde la visión de los prestadores de servicios.   El documento incluye una revisión minuciosa del marco normativo y legal para el caso colombiano de prestadores de servicios turísticos, Normas Técnicas Sectoriales y permite hacer una medición cualitativa y cuantitativa en aspectos como: Tipo de servicio, especialidad, capacidad del establecimiento, formalización, generación de empleo, condiciones de accesibilidad para personas en condición de discapacidad, uso de medios de promoción entre otros.  Para las autoridades locales y regionales la aplicación de la guía les permite conocer información relevante para generar políticas enfocadas a la solución de las debilidades que se detectan y enfocarse a coordinar las actividades que redunden en beneficio del sector turístico colombiano.
Arte rupestre en Colombia
Authors: Argüello García Pedro María
Published: November 2023

Este libro reúne algunos de los aportes recientes en la investigación sobre el arte rupestre colombiano, a la par que expone algunos debates en torno a su proceso de patrimonialización.  Producto de un seminario realizado en 2016 con el mismo nombre, pretende entregar al lector un panorama de la diversidad de problemáticas, enfoques y derroteros de la investigación referente al tema en el país.  Abre distintas ventanas para la comprensión de este complejo entramado de significados que se materializa en pinturas y petroglifos, profusamente diseminados a lo largo ancho del territorio nacional, pero poco estudiados científicamente.
Implementasi Desentralisasi Pendidikan di SMA Negeri 6 Batang Hari
Authors: Sari Dina Ratna , Trisoni Ridwal
Published: November 2023

Desentralisasi pendidikan membawa dampak positif maupun negatif bagi setiap sekolah yang menerapkannya. Tujuan penelitian ini adalah untuk mengetahui implementasi desentralisasi pendidikan di SMA Negeri 6 Batang Hari. Jenis penelitian ini adalah penelitian deskriptif kualitatif. Responden penelitian ini berjumlah 5 orang yang meliputi kepala sekolah, wakil kepala sekolah, guru-guru dan staf kependidikan. Instrumen penelitian ini adalah pedoman wawancara tentang implementasi desentralisasi pendidikan di SMA Negeri 6 Batang Hari. Teknik pengumpulan data dalam penelitian ini adalah melalui wawancara terstruktur dan mendalam. Teknik analisis data yang digunakan dalam penelitian ini adalah teknik SWOT (Strengths, Weaknesses, Opportunity, Threats). Hasil penelitian ini menunjukkan bahwa: 1) bentuk desentralisasi pendidikan di SMA Negeri 6 Batang Hari yaitu Manajemen Berbasis Sekolah (MBS), sistem zonasi sekolah, dan pengintegrasian teknologi dalam kegiatan pendidikan, 2) dampak positif desentralisasi pendidikan di SMA Negeri 6 Batang Hari yaitu peningkatan kualitas pendidikan, efesiensi administrasi pendidikan dan penyetaraan pendidikan, 3) dampak negatif desentralisasi pendidikan di SMA Negeri 6 Batang Hari yaitu adanya kekuasaan baru yang belum kompeten, adanya celah untuk praktek Korupsi, Kolusi dan Nepotisme, serta menimbulkan tantangan lainnya.
Perencanaan Sumber Daya Manusia dalam Pendidikan Masa Depan
Authors: Merentek Theo Chanra , Sumual Tinneke Evie , Usoh Elni Jeini , Kampilong Joni Kutu
Published: November 2023

Penelitian ini bertujuan mengetahui perencanaan sumber daya manusia (SDM) dalam pendidikan masa depan. Jenis penelitian menggunakan kualitatif dengan analisis deskriptif dan pengumpulan data berupa studi literatur. Oleh karena itu didapatkan dari beberapa referensi meliputi artikel, buku, atau karya ilmiah lainnya yang terkait dengan topik pembahasan. Berdasarkan penelitian menunjukkan bahwa tercapainya tujuan dan sasaran pendidikan akan tergantung pada perencanaan, yang di dalamnya termasuk perencanaan SDM. Terdapat beberapa kegiatan yang dapat dilakukan saat merencanakan sumber daya untuk pendidikan yaitu, mengidentifikasi tujuan sekolah, mendefinisikan filosofi, visi,  dan misi sekolah, mengkaji data dan informasi awal yang dimiliki, memilih solusi alternatif guna mencapai tujuan, mengidentifikasi sumber daya manusia maupun material, menganalisis hambatan yang dapat menghalangi, mencari tahu berbagai tahapan dalam proses perencanaan.
Pengembangan Sumber Daya Pendidik Melalui Peningkatan Kualitas Pendidikan Profesi Guru Prajabatan di Indonesia
Authors: Tintingon Josly Yakob , Usoh Elni Jeini , Sumual Tinneke Evie Meggy
Published: November 2023

Penelitian ini bertujuan untuk mengkaji pengembangan sumber daya pendidik melalui peningkatan kualitas pendidikan profesi guru prajabatan di Indonesia. Penelitian ini termasuk kedalam literatur review berdasarkan analisis mendalam dari sumber yang relevan. Hasil analisis data di lapangan diketahui dengan 3,3 juta guru dengan 1,5 juta guru sudah tersertifikasi profesi (45%) sisanya belum tersertifikasi (55%) mengidentifikasikan bahwa lebih banyak guru yang belum tersertifikasi profesi. Selain itu di Indonesia masih kurang dalam skala nasional berkisar 1,4 juta guru. Tentunya perlu dilakukan peningkatan jumlah guru dan profesionalitasnya. Hal ini dapat dilakukan dengan alternatif kebijakan program PPG Prajabatan. Hasil pembahasan dalam penelitian ini diketahui bahwa memang terdapat peningkatan dari segi kemampuan guru pasca mengikuti PPG dibandingkan guru yang tidak mengikuti PPG. Namun pelaksanaan ini perlu dilakukan asesmen dan evaluasi berkelanjutan agar berjalan optimal.
BAŞARI SEVİYESİ DÜŞÜK OKULLARDA OKUL KÜLTÜRÜNÜN İNCELENMESİ
Authors: KAYIKÇI Kemal , ENGÜR Arzu , BEKTAŞ ALTIOK Gül Remziye
Published: November 2023

Bu araştırmanın amacı ilköğretim kademesinde akademik olarak başarı seviyesi düşük resmi okullarda çalışan yönetici ve öğretmenlerin görüşlerine göre başarı seviyesi düşük okulların okul kültürü özelliklerini incelemektir. Araştırma nitel araştırma yönteminde ve durum çalışması desenindedir. Araştırma verileri görüşme tekniğinden yararlanılarak, yapılandırılmış görüşme formu kullanılarak toplanmıştır. Verilerin analizinde NVIVO12 nitel araştırma paket programı kullanılarak betimsel analizi yapılmıştır. Araştırmanın çalışma grubunu, 2017-2018 eğitim öğretim yılında Antalya ili Muratpaşa, Kepez ilçesine bağlı, TEOG başarısı düşük 2 farklı resmi ilköğretim kurumunda görev yapmakta olan ve amaçlı örnekleme yöntemlerinden kolay ulaşılabilir durum örneklemesi yoluyla seçilen 2 yöneticiden ve 8 öğretmenden oluşan toplam 10 katılımcı oluşturmaktadır. Yapılan araştırmada elde edilen veriler genel olarak değerlendirildiğinde insancıl – destekleyici olma özelliğinin yüksek olduğu, çalışanların karara katılımlarının yüksek olduğu, çoğunlukla okul çalışanlarının dayanışma içinde oldukları, ilişkilerde içtenlikle duygu ve düşüncelerini paylaştığı ve çatışma yerine uzlaşma stratejisini benimsedikleri, insan ilişkilerinin iyi olmasının daha çok önemsendiği ve insani değerlerin akademik başarıdan daha değerli görüldüğü, ödüllendirme çalışmalarının yeterli görülmediği, çalışanların hatalardan kaçınma gereğine inandığı ve kurallara uyma eğiliminde olduğu, çalışanların gelişimi için yapılan çalışmaların yetersiz olduğu ve yapılan faaliyetlere ilginin çok olmadığı sonucuna varılmıştır.
Revisiting the Customs Act 1969 in line with WCO’s International Convention on the Simplification and Harmonization of Customs Procedures 1974
Authors: Islam Mohammad Towhidul , Alam Khurshid
Published: November 2023

In the present-day system of integrated world economy, the administration of customs or customs procedure clearly carries considerable effects on the trade transactions both within the border and beyond. In fact, the gravity of the cross-border business potentials leads to the realization of simplifying and harmonizing the customs procedures all over the world. Moreover, the development and operation of the modern customs administration signifies, by and large, a radical shift from the revenue collection to the trade facilitation focus. In the current day, it has become almost a universal belief that trade facilitation and removal of trade barriers go hand in hand with simplification and harmonization of customs procedures. The World Customs Organization (WCO) with this in mind had the Revised Kyoto Convention (RKC) enacted in 1974. The customs regime of Bangladesh is still dependant on the half century old the Customs Act, 1969. Although some changes have been brought to bring it in line with the RKC, many of its provisions are still the same. This creates an impediment towards trade facilitation and economic growth. This paper discusses the differences between the provisions of RKC and Customs Act, 1969 and recommends the changes that are required to be brought in the customs regime of Bangladesh for overall trade facilitation and economic development of the country.
Human Rights Violations in Indonesia’s National Strategic Development Project
Authors: Herwati Siti Rakhma Mary , Wungkana Pascal David
Published: November 2023

The Indonesian Legal Aid Foundation has identified several typologies of structural land cases. One of them is land cases concerning the development of infrastructure projects. In recent years, the government has intensified particular infrastructure projects by designating them as National Strategic Projects (PSN). The designation of certain locations for these National Strategic Projects often overrules the consent of local communities who will be affected by the project. Some cases of infrastructure project development have occurred and impacted such communities. This paper will explicate how the accelerated development of infrastructure projects through the issuance of the Presidential Regulation on National Strategic Projects in 2016 and 2017 have violated community rights to land, the environment, and other human rights. The author will reveal the violation of these rights through examining cases on the construction of the Bener Dam in Central Java and the development of Bitung Toll Road in North Sulawesi. This paper projects one main finding that the government did not use the right to development approach and public needs-based approach in carrying out the project developments. Violations on a couple cases of development, such as Bener Dam and Bitung Toll Road, strengthen the analysis of governmental arbitrariness on conducting PSN in Wadas and Bitung.
NILAI ESTETIKA FILM DOKUMENTER EKSOTIKA MERU BETIRI
Authors: Diputra Gita Pradhana , Hartanto Denny Antyo , Raharjo Christanto P
Published: November 2023

Penelitian ini membahas tentang teori estetik bobot A.A.M Djelantik untuk menemukan unsur-unsur keindahan  dalam film dokumenter Eksotika Meru Betiri di tinjau dari aspek sinematografi. Tujuan penelitian dilakukan adalah untuk mendeskripsikan unsur-unsur  keindahan dalam film dokumenter Eksotika Meru Betiri dan mengetahui peranan sinematografi dalam mempertegas nilai estetik bobot, yaitu : suasana, gagasan, dan anjuran yang terkandung. Penelitian ini menggunakan jenis penelitian kualitatif dengan menggunakan metode deskriptif. Berdasarkan penelitian yang dilakukan terdapat nilai-nilai keindahan pada film dokumenter Eksotika Meru Betiri, yaitu nilai keindahan alam, keindahan moral, keindahan susila, dan keindahan akal. Aspek-aspek sinematografi yang digunakan adalah berfokus pada aspek framing, yaitu hubungan kamera dengan objek seperti batasan wilayah gambar, jarak, ketinggian dan pergerakan kamera.
Das Erwerbssystem in dynamischer Perspektive
Authors: Struck Olaf
Published: November 2023

Dieser Text ist vor einiger Zeit für das Lehrbuch „Arbeit, Markt und Politik“ geschrieben worden. Es handelt sich um eine problemorientierte Einführung in die Arbeitsmarktpolitik, veranschaulicht anhand des Standes der Forschung zu Erwerbsverläufen präformierende Chancen und Risiken durch Herkunft, Bildung, Ausbildung und Berufseinstieg beim Übergang vom Bildungssystem ins Erwerbsleben. Ursachen von stabil oder instabil, von chancenreich oder prekär verlaufender Erwerbskarrieren lassen sich allein anhand von Längsschnittdaten beobachten. Deutlich wird dabei insbesondere die Rolle des dualen Berufsausbildungssystems in der Bundesrepublik, die Bedeutungen von Erstplatzierung am Arbeitsmarkt oder von Betriebsmerkmalen sowie der Einfluss der staatlichen Arbeitsmarktpolitik auf die Entwicklung von Erwerbsverläufen im Zeitverlauf. Aufgezeigt werden eine verfestigte Ungleichheiten im Erwerbsverlauf sowie geringe Einflussnahme der Arbeitsmarktpolitik auf Chancenstrukturen für benachteiligte Gruppen im Erwerbssystem.
The Basin Network : A Model for Data Sharing and Exchange
Authors:   , Kasrin Nasr
Published: November 2023

How can we facilitate the exchange of datasets and other data assets across heterogeneous technical and social environments? This is a classical problem that is more relevant today than ever before, relevant both on a global scale as well as the scale of organizations. We need to distinguish between two notions of data sharing and exchange: one based on the integration of data at the schema level, and the other, which is our focus here, is based on the description, publication, discovery, compilation of data as an asset (similar to how a book is managed in a library). The state-of-the art of the data sharing and exchange problem is polarized. On one end we have emerging 'platforms' which can be susceptible to become walled-gardens that do not interoperate with each other. On the other, we have recommendations such as FAIR guidelines, or architectural abstractions such as data lake and data catalog that help orchestrate vendors in developing interoperable technologies; taking us in the right direction but not too far, due to being too high-level and more normative/prescriptive than constructive. This work fills a gap by making a (1) 'medium-level' proposal, (2) in the form of a constructive recommendation (an architectural pattern), (3) which incorporates several major recommendations. We propose the Basin Network, a distributed architectural pattern which revolves around two novel abstractions: the Offering (message exchange format) and the Basin (node). We adopt an indirection approach: a data asset is managed and exchanged via a surrogate (intermediate representation) which identifies, represents, describes, and effectively 'stands in' for it. The Offering is a model for such surrogates; built on the URI-Resource framework for hypermedia authoring but avoiding some of its pitfalls. The Basin is structure to author, catalog, and manage Offerings and exchange them with other Basins (publish/subscribe), resulting in a Basin Network (akin to a network of data lakes). We demonstrate the applicability of the proposal by applying it to use-cases in three domains: a computer-aided manufacturing project, an IoT project in smart agriculture, and one in crowd data management.
Resposta à crítica de Hoffmann e Jesus ao Índice de Miséria Ampliado
Authors: Saboia João , Hallak Neto João
Published: November 2023

O objetivo do artigo é responder a crítica a nossa proposta de Índice de Miséria Ampliado (IMA) e atualizar seus resultados com mais um ano na série. Os autores da crítica relatam uma divergência em relação às medidas de pobreza, especificamente no ano 2020. Nossa resposta é mais uma oportunidade para apresentar a metodologia e o objetivo do IMA, bem como para apresentar a atualização da série até o ano 2022, em virtude da disponibilização dos dados de rendimento domiciliar per capita, por meio da recente divulgação da PNAD Contínua.
EARLY MARRIAGE MODELING IN WEST JAVA USING GEOGRAPHICALLY WEIGHTED REGRESSION
Authors: Simatupang Marnita
Published: November 2023

Woman early marriage defined as a marriage that happens to a woman under 16 years. Early marriage can affect the mother’s and baby’s health. Free sex, education, and poverty remain the three significant factors of early marriage. West Java Province is the third-highest province with cases of early marriage with 19.23% of cases in Indonesia in the year of 2020. The cases number of cases of early marriage in an area certainly has different characteristics. The proximity factor between regions can influence it. This study aims to model instances of early marriage in West Java Province by considering spatial aspects using the Geographically Weighted Regression (GWR) method. The existence of spatial dependence and heterogeneity is proven by Moran’s Index and Breusch-Pagan value less than alpha (0.05). The results of GWR modeling using Gaussian Kernel Weights show that the Percentage of Woman Who Got Pregnant before 16 Years Old (X1), Average Years of Schooling for Woman (X2),  and Percentage of Poor People (X3), have significant impact of the percentage of early marriage in West Java.  The Percentage of Woman Who Got Pregnant before 16 Years Old (X1) variable and the Percentage of Poor People variable (X3) have a positively affects the percentage of early marriage in West Java Province in 2020. At the same time, Average Years of Schooling for Woman (X2) has a negative effect. Based on calculations, the best model in modeling early marriage in West Java Province is the GWR model, with an adjusted R2 value of 93.18%.
MODELING OF MATERNAL MORTALITY (MMR) IN EAST JAVA 2017-2019 USING PANEL REGRESSION APPROACH
Authors: Febriyanto Eka Cahya , Indawati Rachmah , Mahmudah Mahmudah , Ama Fuad , Ashari Faisal Yusuf
Published: November 2023

Maternal Mortality Rate (MMR), is a country's welfare indicator especially about the women's health. It is included in the development index and the quality of life index. The determinants of maternal mortality are elements that collectively cause maternal mortality. This quantitative research used secondary data on MMR and its influencing factors in East Java Province during the 2017-2019 period and the analysis of the panel data used regression. The trend of Maternal mortality in East Java Province has decreased from year to year; in 2019, it was 89.81 per 100,000 live births. The variable pregnant women using blood-added pills (X1) with a probability value of 0.020 (p<0.05) is found to significantly affected the maternal mortality in the panel regression analysis utilizing the Random Effect Model. The Random Effect Model, which this study found to be the best, contains the model equation Yit = 225.7721 - 1.919457 X1it and the administration of blood-added pills is the variable that significantly affects maternal mortality. The results of this study indicate the need for educational efforts, especially regarding to the benefits of blood-added pills for pregnant women and to correct the misunderstanding about the benefits of blood-added pills in the community, so that the coverage of blood supplement consumption in pregnant women can be increased. Together with the primary health care system and obstetricians, an integrative approach and counseling among pregnant women and their partners will increase awareness of maternity health and birth management.
ELDERLY AND HEALTH INSURANCE COVERAGE IN INDONESIA
Authors: Raharja Mugia Bayu , Zaly Nedra Wati , Fadila Wisnu , Catursaptani Robani , Utomo Wahyu
Published: November 2023

Ensuring quality health coverage for all, especially for older people, is one of the SDGs goals to be achieved. Goal 3 with target 3.8 on universal health coverage (UHC), emphasizes the importance of all people having access to quality health services without the risk of financial hardship. This study aimed to determine the coverage of the National Health Insurance (NHI) and factors related to the ownership of NHI among elderly people in Indonesia. Data from the 2020 National Socio-Economic Survey was used to analyze 121,961 elderly people aged 60 years and above across all provinces in Indonesia. The variables studied included socio-demographic variables, economic status, and health status of the elderly. A chi-square test and binary logistic regression analysis was used to determine the relationship between NHI ownership status and the independent variables. The results showed that most of the elderly were aged 60-69 years, had low education, and lived in rural areas. NHI coverage for the elderly in Indonesia is already good, although there are still high disparities in some regions. The result of logistic regression analysis showed that the NHI ownership status of the elderly has a significant relationship with age, place of residence, education level, and wealth status. Efforts to expand the reach of NHI for the elderly should be increased as one of the strategies in realizing the SDGs targets.
Design of Additional Dissipative Structures for Seismic Retro-fitting of Existing Buildings
Authors: Bergami Alessandro Vittorio
Published: November 2023

This paper presents an innovative approach for improving the seismic protection of existing structures by introducing an additional dissipative structure (ADS). The seismic energy impacting the building can be dissipated through the contribution provided by the ADS, thereby reducing the need for the existing building to ensure its own seismic capacity. This retrofitting technique is well-suited for structures facing architectural restrictions or challenging-to-update elements. It can help address foundation issues by applying loads to new external components. This paper describes the design of the ADS and proposes a displacement-based design procedure. The design process involves a non-linear static analysis and a simple procedure that must be iteratively repeated until the retrofitting target is achieved. This approach is simple and computationally efficient and can also be used for complex and irregular structures. Such structures are frequently encountered, and existing structures often exhibit unusual geometries and materials requiring extensive numerical modeling. The efficacy of the technique was evaluated using a case study involving a school building located in central Italy. The results of numerical analyses indicated that owing to the ADS’s contribution, the seismic capacity of both the buildings was enhanced, ad-dressing the challenges associated with complex foundation interventions.
Convergence Criteria for Fixed Point Problems and Differential Equations
Authors: Sofonea Mircea , Tarzia Domingo Alberto
Published: November 2023

We consider a Cauchy problem for differential equations in a Hilbert space $X$. The problem is stated in a time interval $I$, which can be finite or infinite. Weuse a fixed point argument for history-dependent operators to prove the unique solvability of the problem. Then, we state and prove convergence criteria for both a general fixed point problem and thecorresponding Cauchy problem. These criteria provide necessary and sufficient conditions on a sequence $\{u_n\}$ which guarantee its
convergence to the solution of the corresponding problem, in the space of both continuous and continuously differentiable functions. We then specify our results in the study of a particular differential equation governed by two nonlinear operators. Finally, we provide an application in viscoelasticity and give a mechanical interpretation of the corresponding convergence result.
Effect of Geometrical Confinement on Ordering of Thermoplastic Polyurethanes With Crystallizable Hard and Soft Blocks
Authors: Abukaev Ainur F. , Gorbunova Marina , Anokhin Denis V. , Ivanov Dimitri A.
Published: November 2023

The structural evolution and phase composition of multi-block thermoplastic polyurethanes, with different nature of the soft segments based on poly(butylene adipate) (PBA), were analyzed during in-situ thermal treatments. A combination of synchrotron small- and wide-angle X-ray scattering, differential scanning calorimetry, thermogravimetric analysis, and FTIR spectroscopy was used to determine the influence of macrodiol nature and crystallization conditions on the polymorphic behavior of PBA. Using a new synthesis scheme, a relatively high degree of crystallinity for urethane blocks was achieved, which depends on the diisocyanate type in the structure of the soft segment. The hard segment domains impose geometrical constraints on PBA, thereby altering its crystallization process compared to the neat oligomer. Thus, crystallization after annealing at a low temperature (80 °C) is fast, predominantly yielding a metastable β-phase. When heated to 180 °C, which is higher than the hard-segment melting temperature, a phase-separated structure is observed. Subsequent crystallization is slower, favoring the formation of the stable α-PBA modification. The phase separation can be observed even after the hard block melting. A notably slow crystallization from an isotropic melt was documented after the disruption of phase separation at 230 °C.
Association of Maternal Age and Blood Markers for Metabolic Disease in Newborns
Authors: Xie Yuhan , Peng Gang , Zhao Hongyu , Scharfe Curt
Published: November 2023

Pregnancy at advanced maternal age is considered a risk factor for adverse maternal, fetal, and neonatal outcomes. Here we investigated whether maternal age could be associated with differences in the blood levels of newborn screening (NBS) markers for inborn metabolic disorders on the Recommended Universal Screening Panel (RUSP). Population-level NBS data from screen-negative singleton infants were examined, which included blood metabolic markers and covariates such as gestational age, birth weight, age at blood collection, infant sex, parent-reported ethnicity, and maternal age at delivery. Marker levels were compared between maternal age groups (age range: 15-44 years) using effect size analyses, which controlled for group size differences and potential confounding from other covariates. Our results showed that 13% of the markers had maternal age-related differences including newborn metabolites with either increased (C14, C16, C18, C18:1, C3DC) or decreased (C5OH) levels at advanced maternal age group (≥35 years, absolute Cohen’s d ≥ 0.2). The increased C3DC levels in this group correlated with a higher false-positive rate in newborn screening for malonic acidemia (p-value < 0.001), while no significant difference in screening performance was seen for other markers. Maternal age at delivery is associated with inborn metabolic differences and should be considered together with other clinical variables in genetic disease screening.
Metagenomics-Based Discovery of New Hepadnaviruses
Authors: Ben Haijing , Wang Xuejun , Yang Pengxiang , Li Lin , Liu Pengxiang , Gao Yuxue , Wang Yanjun , Liu Yali , Huang Chunyang , Chen Dexi
Published: November 2023

Background: With continuous advances in next-generation sequencing (NGS), novel hepadnaviruses have been discovered in many species over the last 10 years. Methods: In this study, the cloud search and analysis of NGS data published in Nature by Edgar et al. was used as a basis to re-mine and reanalyze public NGS data for new hepadnaviruses. Results: Ultimately, at least 41 new species of hepadnaviruses were identified, including hepadnaviruses from the model animals hamster and mouse, frog hepadnavirus with pan-species infectivity, and diverse African cichlid hepadnaviruses that circulate within populations. Conclusions: The discovery of the new species of hepadnaviruses not only provides new clues for the study of the origin and evolution of hepadnaviruses, but also can be used to construct new hepadnavirus animal infection models, which will be helpful for the research of eradicative drugs for hepatitis B virus (HBV).
The Naturally Occurring m1A RNA Modification Can Be Efficiently Incorporated into RNA by SARS-CoV-2 RdRp
Authors: Apostle Alexander , Arneson Reed , Yuan Yinan , Fang Shiyue
Published: November 2023

When it is in the template RNA, the naturally occurring m1A epitranscriptomic RNA modification was recently reported to be able to stop the RNA polymerization reaction catalyzed by the RNA dependent RNA polymerase (RdRp) of SARS-CoV-2. In this report, we report that m1A via its triphosphate form (m1ATP) can be incorporated into RNA by the same RdRp. These two findings point a new direction for antiviral drug development based on m1A for combatting COVID-19. More broadly, it is possible that the large pool of epigenetic RNA as well as DNA modifications could serve as a treasury for drug discovery aimed at combating various infectious and other diseases.
Hybrid Superconducting/Superconducting Mesoscopic Heterostructure Studied by Modified Ginzburg-Landau Equations
Authors: González Jesús , Meléndez Angélica María , Camargo Luis Leonardo
Published: November 2023

Studies involving vortex in hybrid superconducting devices and their interaction with different components inside the sample are an important issue to reach higher values of their critical parameters in superconducting materials. The vortex distribution on each side of sample with different fundamental parameters, such as temperature T, penetration depth λ, coherence length ξ, electron mass m and the order parameter Ψ, may help to improve the superconducting properties. Thus, in this work, we used the modified Ginzburg-Landau theory to investigate hybrid superconductor (HS), but also to provide a highly tunable and adjustable theoretical tool to theoretically explain the experimental results involving HS, in order to study the vortex behaviour in superconductors of mesoscopic dimensions with extremely differences among their fundamentals parameters. Therefore, we evaluated the influence of HS on vortex configuration and their effects in the field-dependent magnetization. The results show that the during the increment of applied magnetic field H the diamagnetic response of HS, Meissner effect, include additional jumps of magnetization while diamagnetism continues its increase in the sample. In addition, the differences among parameters, create an interface between both components, two different magnitudes of supercurrent and vortex sizes producing a lower degradation of local superconductivity, which increase the upper critical field. On the other hand, this type HS with differences of parameters on both sides can be used to control the vortex movement in the selected superconducting region sample with more accuracy.
Resonating with the World: Thinking Critically about Brain Criticality
Authors: Leisman Gerry , Koch Paul
Published: November 2023

Abstract: Aim: Biofields combine many physiological levels both spatially and temporally. These biofields reflect naturally resonant forms of synaptic energy reflected in growing and spreading waves of brain activity. The study desires to theoretically understand better how resonant continuum waves may be reflective of consciousness, memory, and thought. Background: The metabolic processes that maintain animal cellular and physiological function are enhanced by physiological coherence. Internal biological system coordination and sensitivity to particular stimuli and signal frequencies are two aspects of coherent physiology. There exists significant support for the notion that exogenous biologically and non-biologically generated energy entrains human physiological systems. All living things have resonant frequencies that are either comparable or coherent, therefore eventually all species will have a shared resonance. An organism's biofield activity and resonance are what support its life and allow it to react to stimuli. Methods: As the naturally resonant forms of synaptic energy are growing and spreading waves of brain activity, The temporal and spatial frequency of waves are effectively regulated by a time delay (T) in inter-layer signals in a layered structure that mimics the structure of the mammalian cortex. From ubiquitous noise, two different types of waves can arise as a function of T. One is coherent, and as T rises, so does its resonant spatial frequency. Results: Continued growth eventually causes both the wavelength and the temporal frequency to abruptly increase. Two waves expand simultaneously and randomly interfere in an area of T values as a result. Conclusion: We suggest that because of this extraordinary dualism, which has its roots in the phase relationships of amplified waves, coherent waves are essential for memory retrieval whereas random waves represent original cognition.
Bacterial Conjunctivitis in Hadhramout Governorate-Yemen
Authors: Al-Haik Wedad , Al-Haddad Ahmed , Edrees Wadhah , Al-Kaf Ali , Abdulkareem Ahmed
Published: November 2023

Background: Bacterial conjunctivitis is one of the most commonly encountered eye complications in medicine, particularly in developing nations. In Hadhramout Governorate-Yemen, there is no data about bacterial conjunctivitis among patients. Aim: The present study aimed to determine the prevalence rate of bacterial conjunctivitis among patients seeking hospitals in Hadhramout Governorate, Yemen. Methods: A total of 1722 eye swabs were collected from patients attending different Hadhramout hospitals over a period of April to December 2018. The isolation and identification of bacteria are performed using standard bacteriological procedures. In addition, structured questionnaires were used to gather data from patients. Results: Out of 1722 eye swabs, 198 (11.49%) were positive for bacterial conjunctivitis, while 1524 (88.5%) were negative. The high prevalence rate of infection was among female participants and the age group between 31 and 40 years, at 15.25% and 29.29%, respectively. In addition, the prevalence of gram-positive bacteria was significantly greater among study patients than gram-negative bacteria (58.59% vs. 41.41%). The most predominant Gram-positive bacteria were Staphylococcus aureus (26.26%), followed by Streptococci pneumoniae (17.18%), Alpha-hemolytic Streptococci (8.08%), and Staphylococcus epidermidis (7.07%). Whereas the gram-negative bacteria were Pseudomonas aeruginosa (12.1%), followed by Moraxella catarrhalis (10.1%), Haemophilus influenza (7.07%), Klebsiella sp. (6.06%), Enterobacter agglomerans (4.04%), and Neisseria gonorrhoeae (2.02%). Additionally, the majority of study patients suffered from red eyes (100%), tearing eyes (93.93%), itching (90.9%), painful eyes (87.87%), purulent eyes (56.56%), and eye discharge (38.38%). Conclusion: The prevalence rate of bacterial conjunctivitis among patients in Hadhramout, Yemen, is relatively low compared with international investigations. Further investigation is required to assess and identify the antibiotic resistance to these agents that cause conjunctivitis.
Burnout, Mental Resilience and Quality of Life in Greek Professionals of Public and Private Sector: Which Is the Impact of Demographic, Occupational and Psychological Variables?
Authors: Theofilou Paraskevi , Vlastos Dimitris D. , Plemmenos Nikolaos
Published: November 2023

The research investigated the relationship between burnout syndrome and the variables of mental resilience and quality and enjoyment of life, in Greek private and public sector workers (N=112), with demographic differences. Data were collected through a structured questionnaire which was distributed in the form of an electronic Microsoft forms. The questionnaire contained demographic questions, the psychometric tool Burnout Assessment Tool version 2.0 (Schaufeli et al., 2019), the psychometric tool Brief Resilience Scale (BRS) (Smith et al., 2008), and the psychometric tool Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q) (Endicott et al., 1993) which were used to measure the three variables examined by the research. For statistical analysis, Pearson and Spearman correlation coefficients were used to test the relationship between two quantitative variables, while linear regression analysis was used to find independent factors. The main research hypothesis was verified, finding a negative correlation between burnout and the variables of mental resilience and quality of life, while it was identified that employees experienced greater exhaustion and spiritual withdrawal compared to freelancers. Hypotheses regarding age, educational level, and public-private job data were not verified as there were no statistically significant differences in demographic results.
About Unitary States and Commutative Gates in a Two-Qubit Quantum System
Authors: Gabbassov Mars , Oralbekov Bakytzhan , Daulet Batyrzhan
Published: November 2023

This work is devoted to the construction and study of commutative gates for a two-qubit quantum system. Using four-dimensional algebra developed by the Kazakh mathematician Abenov M.M. all groups of commutative gates have been constructed, and among all states of a two-qubit quantum system, unitary states with which a specific gate is connected have been identified. An explicit type of gate is described that transfers a quantum system from one unitary state to another unitary state. The proposed approach opens up new possibilities for the design of quantum algorithms not only for two-qubit quantum systems, but also for $n$-qubit quantum systems.
A Functional Single Nucleotide Polymorphism in the 3'-UTR of the Porcine JARID2 Gene is Associated with Aggressive Behavior of Weaned Pigs after Mixing
Authors: Yang Huan , Zhang Chunlei , Chao Xiaohuan , Zhao Jing , Liu Mingzheng , Chen Jiahao , Liu Shuhan , Wang Tianshuo , Muhammad Asim , Schinckel Allan P. , Zhou Bo
Published: November 2023

In pig production, pigs often show more aggressive behavior after mixing, which adversely affects animal welfare and growth performance. The Jumonji and structural domain-rich AT interaction domain 2 (JARID2) gene plays an important role in neurodevelopment in mice and various psychiatric disorders in humans. The JARID2 gene may impact the aggressive behavior of pigs. By observing the behavior of 500 weaned pigs during the first 72 hours after mixing, the ear tissue samples of the 12 most aggressive and 12 least aggressive pigs were selected for DNA resequencing based on the intensity of their aggressive behavior. Large group correlation analysis indicated that the rs3262221458 site located in the 3'-UTR region of the porcine JARID2 gene has a strong relationship with aggressive behavior of weaned pigs. Pigs with the mutant TT genotype of rs3262221458 have more aggressive behavior than those pigs with the GG and GT genotypes. The dual luciferase assay indicated that the luciferase activity of the plasmids containing the G allele of rs326221458 was significantly less than plasmids conaining the T allele of rs326221458 and control groups. The binding abiltiy of miR-9828-3p to sequences containing the T allele was less than sequences containing the G allele. The overexpression of miR-9828-3p in porcine neuroglial cells (PNGCs) and PK15 cells significantly decreased the mRNA and protein levels of the JARID2 gene. In addition, miR-9828-3p inhibited the proliferation of PNGCs. After inhibiting miR-9828-3p, the mRNA and protein expression levels of JARID2 increased, and the proliferation of PNGCs showed an opposite trend to the cells that forced expression of miR-9828-3p. In addition, interference with the JARID2 gene by siRNA can effectively inhibit the proliferation of PNGCs. In summary, we found that the rs326221458 locus regulates the expression of the JARID2 gene by affecting the binding of miR-9828-3p and the JARID2 gene, thereby affecting the aggressive behavior of weaned pigs after mixing.
Fraxicon for Optical Applications with Aperture ∼1 mm
Authors: Mu Haoran , Smith Daniel , Ng Soon Hock , Anand Vijayakumar , Le Nguyen Hoai An , Dharmavarapu Raghu , Khajehsaeidimahabadi Zahra , Richardson Rachael T. , Ruther Patrick , Stoddart Paul R. , Gricius Henrikas , Baravykas Tomas , Gailevičius Darius , Seniutinas Gediminas , Katkus Tomas , Juodkazis Saulius
Published: November 2023

Emerging applications of optical technologies are driving the development of miniaturised light sources, which in turn require the fabrication of matching micro-optical elements with sub-1 mm cross sections and high optical quality. This is particularly challenging for spatially-constrained biomedical applications where reduced dimensionality is required, such as endoscopy, optogenetics, or optical implants. Planarisation of a lens by the Fresnel lens approach was adapted for a conical lens (axicon) and was made by direct femtosecond 780 nm/100 fs laser writing in SZ2080™polymer with photo-initiator. Optical characterisation of the positive and negative fraxicons is presented. Numerical modeling of fraxicon optical performance under illumination by incoherent and spatially extended light sources is compared with the ideal case of plane wave illumination. Considering the potential for rapid replication in soft polymers and resists, this approach holds great promise for the most demanding technological applications.
Regularities of Metal Transfer by Nickel-Based Superalloy Tool at Friction Stir Processing of Titanium Alloy, Produced by Wire Feed Electron Beam Additive Manufacturing
Authors: Rubtsov Valery , Chumaevskii Andrey , Knyazhev Evgeny , Utyaganova Veronika , Gurianov Denis , Amirov Alihan , Cheremnov Andrey , Kolubaev Evgeny
Published: November 2023

Keywords: friction stir processing; additive manufacturing; wire; titanium alloy; material transfer; microstructure; microhardness
Deoxycholic Acid, a Secondary Bile Acid, Increases Cardiac Output and Blood Pressure in Rats
Authors: Nowiński Artur , Chabowski Dawid , Giebułtowicz Joanna , Aleksandrowicz Marta , Ufnal Marcin
Published: November 2023

Background: Deoxycholic acid (DCA) is a secondary bile acid produced by gut bacteria. Its serum concentration increases in cardiovascular disease (CVD). We hypothesized that DCA may affect hemodynamic parameters in rats.
Methods: The concentration of DCA in systemic blood was measured with liquid chromatography coupled with mass spectrometry. Arterial blood pressure (BP), heart rate (HR) and echocardiographic parameters were evaluated in anesthetized, male, 3-4-month-old Sprague-Dawley rats administered intravenously (IV) or intracerebroventricularly (ICV) with investigated compounds. Mesenteric artery (MA) reactivity was tested ex vivo.
Results: The baseline plasma concentration of DCA was 0.24 ± 0.03 mg/l. The oral antibiotic treatment produced a large decrease in the concentration. Administered IV, the compound increased BP and HR in a dose-dependent manner. DCA also increased heart contractility and cardiac output. None of the tested compounds: prazosin (an alpha-blocker), propranolol (beta-adrenolytic), atropine (muscarinic receptor antagonist), glibenclamide (K-ATP inhibitor) or DY 268 (FXR antagonist), glycyrrhetinic acid (11HSD2 inhibitor) significantly diminished the DCA-induced pressor effect. ICV infusion did not exert significant HR or BP changes. DCA relaxed MAs. Systemic vascular resistance did not change significantly.
Conclusions: DCA increases BP by increasing cardiac output. As a bioactive gut bacteria-derived metabolite, DCA may co the interaction between gut microbiota and the host’s circulatory system.
Preoperative Accuracy of Acetabular Bone Defect Assessment in Complex Hip Revision Arthroplasty Based on 3D Life‐Sized Model: A Case Series
Authors: La Camera Francesco , Pisano Alessandro , Favazzi Carlo Maria , Guazzoni Edoardo , Di Matteo Vincenzo , Morenghi Emanuela , Grappiolo Guido , Loppini Mattia
Published: November 2023

Abstract: In complex revision total hip arthroplasties, careful preoperative planning is crucial for the proper reconstruction of hip biomechanics. With conventional 2D radiographic images and computed tomography (CT) the 3D extension of the defect and the remaining bone stock may not be evaluated properly. 3D printed models can aid the surgeon in planning complex acetabular re-construction. The purpose of this study is to compare the accuracy of bony defect assessment in severe acetabular defects surgery with 3D printing planning as compared to conventional 2D ra-diographic planning and CT. Twenty-five patients with severe acetabular defects (Paprosky IIC and III) undergoing revision surgery were enrolled. Each patient had a 3D printed model of their femur and pelvis created based on CT scans. Clinical and radiographic assessments were conducted before and after surgery, with four key bone landmarks measured and compared between X-ray, CT, 3D models, and surgical reports. The findings revealed discrepancies in defect assessment between different imaging methods. X-rays and CT scans sometimes incorrectly identified affected areas, while the 3D models showed more accurate results. This study suggests that 3D printed models can significantly improve the preoperative evaluation of complex hip arthroplasty revisions, enabling surgeons to better select optimal surgical strategies.
A Comparative Study on Recent Progress of Machine Learning-based Human Activity Recognition with Radar
Authors: Papadopoulos Konstantinos , Jelali Mohieddine
Published: November 2023

The importance of radar-based human activity recognition increased significantly over the last two decades in safety and smart surveillance applications due to its superiority towards vision-based sensing in the presence of poor environmental conditions, like illumination, increased radiative heat, occlusion, and fog. An increased public sensitivity for privacy protection, and the progress of cost-effective manufacturing, led to a higher acceptance and distribution. Deep learning approaches proved that the manual feature extraction that relies heavily upon process knowledge can be avoided by its hierarchical, non-descriptive nature. On the other hand, ML techniques based on manual feature extraction provide a robust, yet empirical based approach where the computational effort is comparatively low. This review outlines the basics of classical ML- and DL-based human activity recognition and its advances while taking recent progress of both categories into regard. For every category, state-of-the-art methods are introduced, briefly explained and discussed in terms of their pros, cons and gaps. A comparative study is performed to evaluate the performance and computational effort based on a benchmarking data set to provide a common basis for the assessment of the techniques’ degree of suitability.