bluuebunny/crossref_metadata_2025 huggingface dataset:
Is early or late biological maturation trigger obesity? A machine learning modeling research in Turkey boys and girls
Authors: Gülü Mehmet , Yagin Fatma Hilal , Yapici Hakan , Irandoust Khadijeh , Dogan Ali Ahmet , Taheri Morteza , Szura Ewa , Barasinska Magdalena , Gabrys Tomasz
Published: February 2023

Biological maturation status can affect individual differences, sex, height, body fat, and body weight in adolescents and thus may be associated with obesity. The primary aim of this study was to examine the relationship between biological maturation and obesity. Overall, 1,328 adolescents (792 boys and 536 girls) aged 12.00 ± 0.94–12.21 ± 0.99 years, respectively (measured for body mass, body stature, sitting stature). Body weights were deter-mined with Tanita body analysis system and adolescent obesity status was calculated according to the WHO classification. Biological maturation was determined according to the somatic maturation method. Our results showed that boys mature 3.077-fold later than girls. Obesity was an increasing effect on early maturation. It was determined that being obese, overweight and healthy-weight increased the risk of early maturation 9.80, 6.99 and 1.81-fold, respectively. The equation of the model predicting maturation is: Logit (P) = 1/(1 + exp. (− (−31.386 + sex-boy * (1.124) + [chronological age = 10] * (−7.031) + [chronological age = 11] * (−4.338) + [chronological age = 12] * (−1.677) + age * (−2.075) + weight * 0.093 + height * (−0.141) + obesity * (−2.282) + overweight * (−1.944) + healthy weight * (−0.592)))). Logistic regression model predicted maturity with 80.7% [95% CI: 77.2–84.1%] accuracy. In addition, the model had a high sensitivity value (81.7% [76.2–86.6%]), which indicates that the model can successfully distinguish adolescents with early maturation. In conclusion, sex and obesity are independent predictors of maturity, and the risk of early maturation is increased, especially in the case of obesity and in girls.
The positive relationship between androgen receptor splice variant-7 expression and the risk of castration-resistant prostate cancer: A cumulative analysis
Authors: Zhao Shankun , Liao Jian , Zhang Shilong , Shen Maolei , Li Xin , Zhou Libo
Published: February 2023

Background

At present, androgen deprivation therapy (ADT) is still the standard regimen for patients with metastatic and locally advanced prostate cancer (PCa). The level of androgen receptor splice variant-7 (AR-V7) in men with castration-resistant prostate cancer (CRPC) has been reported to be elevated compared with that in patients diagnosed with hormone-sensitive prostate cancer (HSPC).

Aim

Herein, we performed a systematic review and cumulative analysis to evaluate whether the expression of AR-V7 was significantly higher in patients with CRPC than in HSPC patients.

Methods

The commonly used databases were searched to identify the potential studies reporting the level of AR-V7 in CRPC and HSPC patients. The association between CRPC and the positive expression of AR-V7 was pooled by using the relative risk (RR) with the corresponding 95% confidence intervals (CIs) under a random-effects model. For detecting the potential bias and the heterogeneity of the included studies, sensitivity analysis and subgroup analysis were performed. Publication bias was assessed Egger’s and Begg’s tests. This study was registered on PROSPERO (ID: CRD42022297014).

Results

This cumulative analysis included 672 participants from seven clinical trials. The study group contained 354 CRPC patients, while the other group contained 318 HSPC patients. Pooled results from the seven eligible studies showed that the expression of positive AR-V7 was significantly higher in men with CRPC compared to those with HSPC (RR = 7.55, 95% CI: 4.61–12.35, p < 0.001). In the sensitivity analysis, the combined RRs did not change substantially, ranging from 6.85 (95% CI: 4.16–11.27, p < 0.001) to 9.84 (95% CI: 5.13–18.87, p < 0.001). In the subgroup analysis, a stronger association was detected in RNA in situ hybridization (RISH) measurement in American patients, and those studies were published before 2011 (all p < 0.001). There was no significant publication bias identified in our study.

Conclusion

Evidence from the seven eligible studies demonstrated that patients with CRPC had a significantly elevated positive expression of AR-V7. More investigations are still warranted to clarify the association between CRPC and AR-V7 testing.

Systematic review registration

https://www.crd.york.ac.uk/prospero/, identifier CRD42022297014.
Safety and rapid response of dabrafenib and trametinib therapy during hyperbilirubinemia in metastatic melanoma
Authors: Shalata Walid , Steckbeck Rachel , Polishchuk Ilya , Cohen Ahron Yehonatan , Rouvinov Keren , Tokar Margarita , Abu Jama Ashraf , Abu Saleh Omar , Sheva Kim , Yakobson Alexander
Published: February 2023

This case report describes the occurrence of hyperbilirubinemia as a complication of metastatic melanoma. A 72-year-old male patient was diagnosed with BRAF V600E-mutated melanoma with metastases in the liver, lymph nodes, lungs, pancreas, and stomach. Due to a lack of clinical data and specific guidelines for the treatment of mutated metastatic melanoma patients with hyperbilirubinemia, a conference of specialists debated between initiating treatment or providing supportive care. Ultimately, the patient was started on the combination therapy of dabrafenib and trametinib. This treatment resulted in a significant therapeutic response via normalization of bilirubin levels and an impressive radiological response of metastases just one month post-treatment initiation.
Ruxolitinib treatment in myelofibrosis and polycythemia vera causes suboptimal humoral immune response following standard and booster vaccination with BNT162b2 mRNA COVID-19 vaccine
Authors: Palumbo Giuseppe A. , Cambria Daniela , La Spina Enrico , Duminuco Andrea , Laneri Antonio , Longo Anna , Vetro Calogero , Giallongo Sebastiano , Romano Alessandra , Di Raimondo Francesco , Tibullo Daniele , Giallongo Cesarina
Published: February 2023

Patients affected by myelofibrosis (MF) or polycythemia vera (PV) and treated with ruxolitinib are at high risk for severe coronavirus disease 2019. Now a vaccine against the virus SARS-CoV-2, which is responsible for this disease, is available. However, sensitivity to vaccines is usually lower in these patients. Moreover, fragile patients were not included in large trials investigating the efficacy of vaccines. Thus, little is known about the efficacy of this approach in this group of patients. In this prospective single-center study, we evaluated 43 patients (30 MF patients and 13 with PV) receiving ruxolitinib as a treatment for their myeloproliferative disease. We measured anti-spike and anti-nucleocapsid IgG against SARS-CoV2 15-30 days after the second and the third BNT162b2 mRNA vaccine booster dose. Patients receiving ruxolitinib showed an impaired antibody response to complete vaccination (2 doses), as 32.5% of patients did not develop any response. After the third booster dose with Comirnaty, results slightly improved, as 80% of these patients produced antibodies above the threshold positivity. However, the quantity of produced antibodies was well below that reached than those reported for healthy individuals. PV patients elicited a better response than patients affected by MF. Thus, different strategies should be considered for this high-risk group of patients.
Outcomes of beta blocker use in advanced hepatocellular carcinoma treated with immune checkpoint inhibitors
Authors: Wu Y. Linda , van Hyfte Grace , Özbek Umut , Reincke Marlene , Gampa Anuhya , Mohamed Yehia I. , Nishida Naoshi , Wietharn Brooke , Amara Suneetha , Lee Pei-Chang , Scheiner Bernhard , Balcar Lorenz , Pinter Matthias , Vogel Arndt , Weinmann Arndt , Saeed Anwaar , Pillai Anjana , Rimassa Lorenza , Naqash Abdul Rafeh , Muzaffar Mahvish , Huang Yi-Hsiang , Kaseb Ahmed O. , Kudo Masatoshi , Pinato David J. , Ang Celina
Published: February 2023

Background

In patients with cirrhosis, portal hypertension increases intestinal permeability, dysbiosis, and bacterial translocation, promoting an inflammatory state that can lead to the progression of liver disease and development of hepatocellular carcinoma (HCC). We aimed to investigate whether beta blockers (BBs), which can mediate portal hypertension, conferred survival benefits in patients treated with immune checkpoint inhibitors (ICIs).

Methods

We conducted a retrospective, observational study of 578 patients with unresectable HCC treated with ICI from 2017 to 2019 at 13 institutions across three continents. BB use was defined as exposure to BBs at any time during ICI therapy. The primary objective was to assess the association of BB exposure with overall survival (OS). Secondary objectives were to evaluate the association of BB use with progression-free survival (PFS) and objective response rate (ORR) according to RECIST 1.1 criteria.

Results

In our study cohort, 203 (35%) patients used BBs at any point during ICI therapy. Of these, 51% were taking a nonselective BB. BB use was not significantly correlated with OS (hazard ratio [HR] 1.12, 95% CI 0.9-1.39, P = 0.298), PFS (HR 1.02, 95% CI 0.83-1.26, P = 0.844) or ORR (odds ratio [OR] 0.84, 95% CI 0.54-1.31, P = 0.451) in univariate or multivariate analyses. BB use was also not associated with incidence of adverse events (OR 1.38, 95% CI 0.96-1.97, P = 0.079). Specifically, nonselective BB use was not correlated with OS (HR 0.94, 95% CI 0.66-1.33, P = 0.721), PFS (HR 0.92, 0.66-1.29, P = 0.629), ORR (OR 1.20, 95% CI 0.58-2.49, P = 0.623), or rate of adverse events (OR 0.82, 95% CI 0.46-1.47, P = 0.510).

Conclusion

In this real-world population of patients with unresectable HCC treated with immunotherapy, BB use was not associated with OS, PFS or ORR.
Early antibiotics and risk for necrotizing enterocolitis in premature infants: A narrative review
Authors: Cuna Alain , Morowitz Michael J. , Sampath Venkatesh
Published: February 2023

While prompt initiation of antibiotics at birth due to concerns for early onset sepsis is common, it often leads to many preterm infants being exposed to treatment despite negative blood cultures. Such exposure to early antibiotics can impact the developing gut microbiome putting infants at increased risk of several diseases. Necrotizing enterocolitis (NEC), a devastating inflammatory bowel disease that affects preterm infants, is among the most widely studied neonatal disease that has been linked to early antibiotics. While some studies have demonstrated an increased risk of NEC, other studies have demonstrated seemingly contrary findings of decreased NEC with early antibiotics. Studies using animal models have also yielded differing findings of benefit vs. harm of early antibiotic exposure on subsequent NEC susceptibility. We thus sought to conduct this narrative review to help clarify the relationship between early antibiotics exposure and future risk of NEC in preterm infants. Our objectives are to: (1) summarize findings from human and animal studies that investigated the relationship between early antibiotics and NEC, (2) highlight important limitations of these studies, (3) explore potential mechanisms that can explain why early antibiotics may increase or decrease NEC risk, and (4) identify future directions for research.
Sodium-glucose co-transporter-2 inhibitor (SGLT2i) treatment and risk of osteomyelitis: A pharmacovigilance study of the FAERS database
Authors: Zhao Hui , Li Zi-Ran , Zhang Qian , Zhong Ming-Kang , Yan Ming-Ming , Qiu Xiao-Yan
Published: February 2023

Background and purpose: Several clinical trials have indicated that the use of canagliflozin increases the risk of lower extremity amputation. Although the US Food and Drug Administration (FDA) has withdrawn its black box warning about amputation risk for canagliflozin, the risk still exists. We sought to estimate the association between hypoglycemic medications, especially sodium-glucose co-transporter-2 inhibitors (SGLT2is), and adverse events (AEs) before the irreversible outcome of amputation as a promising early warning, based on the FDA Adverse Event Reporting System (FAERS) data.

Methods: Publicly available FAERS data were analyzed using a reporting odds ratio (ROR) method and validated by a Bayesian confidence propagation neural network (BCPNN) method. The developing trend of the ROR was investigated by a series of calculations based on the accumulation of data in the FAERS database quarter by quarter.

Results: Ketoacidosis, infection, peripheral ischemia, renal impairment, and inflammation including osteomyelitis might be more likely to occur among users of SGLT2is, especially canagliflozin. Osteomyelitis and cellulitis are AEs unique to canagliflozin. Among 2,888 osteomyelitis-related reports referring to hypoglycemic medications, 2,333 cases were associated with SGLT2is, with canagliflozin accounting for 2,283 of these cases and generating an ROR value of 360.89 and a lower limit of information component (IC025) of 7.79. No BCPNN-positive signal could be generated for drugs other than insulin and canagliflozin. Reports suggesting that insulin could generate BCPNN-positive signals span from 2004 to 2021, whereas reports with BCPNN-positive signals emerged only since the second quarter (Q2) of 2017, 4 years since the approval of SGLT2is in Q2 of 2013, for canagliflozin and drug groups containing canagliflozin.

Conclusion: This data-mining investigation revealed a strong association between canagliflozin treatment and developing osteomyelitis that might be a crucial forewarning to lower extremity amputation. Further studies with updated data are needed to better characterize the risk of osteomyelitis associated with SGLT2is.
Quantifying robustness of CT-ventilation biomarkers to image noise
Authors: Flakus Mattison J. , Wuschner Antonia E. , Wallat Eric M. , Shao Wei , Shanmuganayagam Dhanansayan , Christensen Gary E. , Reinhardt Joseph M. , Li Ke , Bayouth John E.
Published: February 2023

Purpose: To quantify the impact of image noise on CT-based lung ventilation biomarkers calculated using Jacobian determinant techniques.

Methods: Five mechanically ventilated swine were imaged on a multi-row CT scanner with acquisition parameters of 120 kVp and 0.6 mm slice thickness in static and 4-dimensional CT (4DCT) modes with respective pitches of 1 and 0.09. A range of tube current time product (mAs) values were used to vary image dose. On two dates, subjects received two 4DCTs: one with 10 mAs/rotation (low-dose, high-noise) and one with CT simulation standard of care 100 mAs/rotation (high-dose, low-noise). Additionally, 10 intermediate noise level breath-hold (BHCT) scans were acquired with inspiratory and expiratory lung volumes. Images were reconstructed with and without iterative reconstruction (IR) using 1 mm slice thickness. The Jacobian determinant of an estimated transformation from a B-spline deformable image registration was used to create CT-ventilation biomarkers estimating lung tissue expansion. 24 CT-ventilation maps were generated per subject per scan date: four 4DCT ventilation maps (two noise levels each with and without IR) and 20 BHCT ventilation maps (10 noise levels each with and without IR). Biomarkers derived from reduced dose scans were registered to the reference full dose scan for comparison. Evaluation metrics were gamma pass rate (Γ) with 2 mm distance-to-agreement and 6% intensity criterion, voxel-wise Spearman correlation (ρ) and Jacobian ratio coefficient of variation (CoVJR).

Results: Comparing biomarkers derived from low (CTDIvol = 6.07 mGy) and high (CTDIvol = 60.7 mGy) dose 4DCT scans, mean Γ, ρ and CoVJR values were 93% ± 3%, 0.88 ± 0.03 and 0.04 ± 0.009, respectively. With IR applied, those values were 93% ± 4%, 0.90 ± 0.04 and 0.03 ± 0.003. Similarly, comparisons between BHCT-based biomarkers with variable dose (CTDIvol = 1.35–7.95 mGy) had mean Γ, ρ and CoVJR of 93% ± 4%, 0.97 ± 0.02 and 0.03 ± 0.006 without IR and 93% ± 4%, 0.97 ± 0.03 and 0.03 ± 0.007 with IR. Applying IR did not significantly change any metrics (p>0.05).

Discussion: This work demonstrated that CT-ventilation, calculated using the Jacobian determinant of an estimated transformation from a B-spline deformable image registration, is invariant to Hounsfield Unit (HU) variation caused by image noise. This advantageous finding may be leveraged clinically with potential applications including dose reduction and/or acquiring repeated low-dose acquisitions for improved ventilation characterization.
Effect of exercise and antioxidant supplementation on cellular lipid peroxidation in elderly individuals: Systematic review and network meta-analysis
Authors: Ni Chunxia , Ji Yiyi , Hu Keke , Xing Kai , Xu Yining , Gao Yanan
Published: February 2023

Background: The viewpoints of previous studies on the correlation between exercise and cellular lipid peroxidation are contradictory from many perspectives and lack evidence for elder individuals. A new systematic review with network meta-analysis is necessary and will have significant practical value to provide high-quality evidence in the development of exercise protocols and an evidence-based guide for antioxidant supplementation for the elderly.

Aims: To identify the cellular lipid peroxidation induced by different types of exercise, with or without antioxidant supplementation, in elderly individuals.

Methods: Randomized controlled trials that recruited elderly participants and reported cellular lipid peroxidation indicators and were published in peer-reviewed journals in English were searched by a Boolean logic search strategy and screened in the databases PubMed, Medline, Embase, and Web of Science. The outcome measures were the biomarkers of oxidative stress in cell lipids in urine and blood, namely F2-isoprostanes, hydrogen peroxide (LOOH, PEROX, or LIPOX), malondialdehyde (MDA), and thiobarbituric acid reactive substances (TBARS).

Result: 7 trials were included. A combination program of aerobic exercise (AE), low-intensity resistance training (LIRT), and a placebo intake (Placebo) and a combination program of aerobic exercise, low-intensity resistance training, and antioxidant supplementation (S) had the most and sub-most potential to dampen cellular lipid peroxidation (AE + LIRT + Placebo: 0.31 in Rank 1 and 0.2 in Rank 2; AE + LIRT + S: 0.19 in Rank 1 and 0.20 in Rank 2); A placebo intake (Placebo) and a blank intervention without exercise (NE) had the most and sub-most potential to induce an enhancement of cellular lipid peroxidation (Placebo: 0.51 in Rank 9 and 0.16 in Rank 8; NE: 0.16 in Rank 9 and 0.28 in Rank 8). All included studies had an unclear risk of selecting reporting. There were no high confidence ratings in all the direct and indirect comparisons, 4 comparisons in the direct evidence structure and 7 comparisons in the indirect evidence structure had moderate confidence.

Conclusion: A combined protocol consisting of aerobic exercise and low-intensity resistance training is recommended to dampen cellular lipid peroxidation. Extra antioxidant supplementation might be unnecessary if an elderly individual has enough aerobic and resistance exercise.

Systematic Review Registration: CRD42022367430
High-mobility group box 1 protein, receptor for advanced glycation end products and nucleosomes increases after marathon
Authors: Schoenfeld Julia , Roeh Astrid , Holdenrieder Stefan , von Korn Pia , Haller Bernhard , Krueger Kimberly , Falkai Peter , Halle Martin , Hasan Alkomiet , Scherr Johannes
Published: February 2023

Background: Prolonged and strenuous exercise has been linked to potential exercise-induced myocardial damages. One potential key to unmask the discussed underlying mechanisms of this subclinical cardiac damage could be markers of immunogenic cell damage (ICD). We investigated the kinetics of high-mobility group box 1 protein (HMGB1), soluble receptor for advanced glycation end products (sRAGE), nucleosomes, high sensitive troponin T (hs-TnT) and high sensitive C-reactive protein (hs-CRP) before and up to 12 weeks post-race and described associations with routine laboratory markers and physiological covariates.

Methods: In our prospective longitudinal study, 51 adults (82% males; 43 ± 9 years) were included. All participants underwent a cardiopulmonary evaluation 10–12 weeks pre-race. HMGB1, sRAGE, nucleosomes, hs-TnT and, hs-CRP were analysed 10–12 weeks prior, 1–2 weeks before, immediately, 24 h, 72 h, and 12 weeks post-race.

Results: HMGB1, sRAGE, nucleosomes and hs-TnT increased significantly from pre- to immediately post-race (0.82–2.79 ng/mL; 1132–1388 pg/mL; 9.24–56.65 ng/mL; 6–27 ng/L; p < 0.001) and returned to baseline within 24–72 h. Hs-CRP increased significantly 24 h post-race (0.88–11.5 mg/L; p < 0.001). Change in sRAGE was positively associated with change in hs-TnT (rs = 0.352, p = 0.011). Longer marathon finishing time was significantly associated with decreased levels of sRAGE [−9.2 pg/mL (β = −9.2, SE = 2.2, p < 0.001)].

Conclusion: Prolonged and strenuous exercise increases markers of ICD immediately post-race, followed by a decrease within 72 h. An acute marathon event results in transient alterations of ICD, we assume that this is not solely driven by myocyte damages.
Physiology and transcriptome analysis of the response mechanism of Solidago canadensis to the nitrogen addition environment
Authors: Wu Miao , Liu Huiyuan , Zhang Ying , Li Bingbing , Zhu Tao , Sun Man
Published: February 2023

Solidago canadensis is an invasive plant that can adapt to variable environmental conditions. To explore the molecular mechanism of the response to nitrogen (N) addition conditions in S. canadensis, physiology and transcriptome analysis were performed with samples that cultured by natural and three N level conditions. Comparative analysis detected many differentially expressed genes (DEGs), including the function of plant growth and development, photosynthesis, antioxidant, sugar metabolism and secondary metabolism pathways. Most genes encoding proteins involved in plant growth, circadian rhythm and photosynthesis were upregulated. Furthermore, secondary metabolism-related genes were specifically expressed among the different groups; for example, most DEGs related to phenol and flavonoid synthesis were downregulated in the N-level environment. Most DEGs related to diterpenoid and monoterpenoid biosynthesis were upregulated. In addition, many physiological responses, such as antioxidant enzyme activities and chlorophyll and soluble sugar contents, were elevated by the N environment, which was consistent with the gene expression levels in each group. Collectively, our observations indicated that S. canadensis may be promoted by N deposition conditions with the alteration of plant growth, secondary metabolism and physiological accumulation.
Female researchers in high-impact psychiatric journals: What do they focus on?
Authors: Trimmel Melanie , Amering Michaela , Suessenbacher-Kessler Stefanie , Schrank Beate , Gmeiner Andrea
Published: February 2023

The regular analysis of publication trends, including gender aspects, is an important contribution to the identification of gender-specific differences in academic psychiatry. The present study aimed to characterise publication topics in three high-impact psychiatric journals across three time points within 15 years (2004, 2014 and 2019). Publication patterns of female authors compared to their male colleagues were examined. All articles published in 2019 in the three high-impact psychiatry journals JAMA Psychiatry, British Journal of Psychiatry and American Journal of Psychiatry were included and compared with data from the 2004 and 2014 assessments. Descriptive statistics were calculated and Chi-square tests were performed. In 2019, a total of 473 articles were published, 49.5% were original research articles, of which 50.4% were published by female first authors. The results of this study showed a stable trend in the publication of research on mood disorders as well as schizophrenia and psychotic disorders in high-ranking psychiatric journals. Although the percentage of female first authors in the three most common target populations under study (mood disorders, schizophrenia and general mental health) increased from 2004 to 2019, gender equality has not yet been achieved in these fields. However, in the two most frequent subject matters, basic biological research and psychosocial epidemiology, the percentage of female first authors was more than 50%. Consistent monitoring of publication trends and gender distribution by researchers and journals in psychiatric research should be continued to identify and counteract the possibility of the underrepresentation of women in certain fields.
The relationship between intolerance of uncertainty, coping style, resilience, and anxiety during the COVID-19 relapse in freshmen: A moderated mediation model
Authors: Wang Ting , Jiang Lingwei , Li Tiantian , Zhang Xiaohang , Xiao Sanrong
Published: February 2023

Background

The repeated outbreaks of COVID-19 and the rapid increase in uncertainty have had many negative effects on the public’s mental health, especially on emotional aspects such as anxiety and depression. However, in previous studies, there are few studies exploring the positive factors between uncertainty and anxiety. The innovation of this study is the first to explore the mechanism of coping style and resilience as people’s psychological protective factors between uncertainty and anxiety caused by the COVID-19 pandemic.

Methods

This study explored the relationship between intolerance of uncertainty and anxiety of freshmen with coping style as mediating variable and resilience as moderating variable. A total of 1049 freshmen participated in the study and completed the Intolerance of Uncertainty Scale (IUS-12), Self-rating Anxiety Scale (SAS), Simplified Coping Style Questionnaire (SCSQ), and Connor-Davidson Resilience Scale (CD-RISC).

Results

SAS score of the surveyed students (39.56 ± 10.195) was significantly higher than that of the Normal Chinese score (29.78 ± 10.07, p < 0.001). Intolerance of uncertainty was significantly positively correlated with anxiety (β = 0.493, p < 0.001). Positive coping style has a significant negative impact on anxiety (β = −0.610, p < 0.001), negative coping style has a significant positive impact on anxiety (β = 0.951, p < 0.001). Resilience moderates the second half of the influence of negative coping style on anxiety (β = 0.011, t = 3.701, p < 0.01).

Conclusion

The findings suggest that high levels of intolerance of uncertainty had negative effects mental burden during the COVID-19 pandemic. The knowledge of the mediating role of coping style and the moderating role of resilience may be used by health care workers when consulting freshmen with physical health complaints and psychosomatic disorders.
Predictive potential of somatic symptoms for the identification of subthreshold depression and major depressive disorder in primary care settings
Authors: Li Xiuwen , Zhang Huimin , Han Xue , Guo Lan , Ceban Felicia , Liao Yuhua , Shi Jingman , Wang Wanxin , Liu Yifeng , Song Weidong , Zhu Dongjian , Wang Hongqiong , Li Lingjiang , Fan Beifang , Lu Ciyong , McIntyre Roger S.
Published: February 2023

Background

The presence of heterogenous somatic symptoms frequently obscures the recognition of depression in primary care. We aimed to explore the association between somatic symptoms and subthreshold depression (SD) and Major Depressive Disorder (MDD), as well as to determine the predictive potential of somatic symptoms in identifying SD and MDD in primary care.

Methods

Data were derived from the Depression Cohort in China study (ChiCTR registry number: 1900022145). The Patient Health Questionnaire-9 (PHQ-9) was used to assess SD by trained general practitioners (GPs), and the Mini International Neuropsychiatric Interview depression module was used to diagnose MDD by professional psychiatrists. Somatic symptoms were assessed using the 28-item Somatic Symptoms Inventory (SSI).

Results

In total of 4,139 participants aged 18–64 years recruited from 34 primary health care settings were included. The prevalence of all 28 somatic symptoms increased in a dose-dependent manner from non-depressed controls to SD, and to MDD (P for trend <0.001). Hierarchical clustering analysis grouped the 28 heterogeneous somatic symptoms into three clusters (Cluster 1: energy-related symptoms, Cluster 2: vegetative symptoms, and Cluster 3: muscle, joint, and central nervous symptoms). Following adjustment for potential confounders and the other two clusters of symptoms, per 1 increase of energy-related symptoms exhibited significant association with SD (OR = 1.24, 95% CI, 1.18–1.31) and MDD (OR = 1.50, 95% CI, 1.41–1.60) The predictive performance of energy-related symptoms in identifying individuals with SD (AUC = 0.715, 95% CI, 0.697–0.732) and MDD (AUC = 0.941, 95% CI, 0.926–0.963) was superior to the performance of total SSI and the other two clusters (P < 0.05).

Conclusions

Somatic symptoms were associated with the presence of SD and MDD. In addition, somatic symptoms, notably those related to energy, showed good predictive potential in identifying SD and MDD in primary care. The clinical implication of the present study is that GPs should consider the closely related somatic symptoms for early recognition for depression in practice.
Association of coffee consumption pattern and metabolic syndrome among middle-aged and older adults: A cross-sectional study
Authors: Nina Ren , Lingling Huang , Qiushuang Li , Honglin Guo , Liyuan Sun , Yuting Zhang
Published: February 2023

Objectives

The association between coffee consumption and the risk of metabolic syndrome (MetS) remains inconsistent. The aim of this study was to evaluate the association between coffee intake and components of MetS.

Method

A cross-sectional survey including 1,719 adults was conducted in Guangdong, China. Data on age, gender, education level, marriage status, body mass index (BMI), current smoking and drinking status and breakfast habit, coffee consumption type, and daily servings were derived based on 2-day, 24-h recall. MetS were assessed according to the International Diabetes Federation definition. Multivariable logistic regression was conducted to examine the association between the coffee consumption type, daily servings, and the components of MetS.

Results

Regardless of the coffee type, compared with non-coffee consumers, coffee consumers had higher odds ratios (ORs) of the elevated fasting blood glucose (FBG) in both men [OR: 3.590; 95% confidence intervals (CI): 2.891–4.457] and women (OR: 3.590; 95% CI: 2.891–4.457). In women, the risk of elevated blood pressure (BP) was 0.553 times (OR: 0.553; 95% CI: 0.372–0.821, P = 0.004) for people who drank total coffee > 1 serving/day than for non-coffee drinkers.

Conclusion

In conclusion, regardless of type, coffee intake is associated with an increased prevalence of FBG in both men and women, but has a protective effect on hypertension only in women.
Axes of social inequities in COVID-19 clinical trials: A systematic review
Authors: Ponjoan Anna , Jacques-Aviñó Constanza , Medina-Perucha Laura , Romero Victor , Martí-Lluch Ruth , Alves-Cabratosa Lia , Ramos Rafel , Berenguera Anna , Garcia-Gil María del Mar
Published: February 2023

Objective

The representativeness of participants is crucial to ensure external validity of clinical trials. We focused on the randomized clinical trials which assessed COVID-19 vaccines to assess the reporting of age, sex, gender identity, race, ethnicity, obesity, sexual orientation, and socioeconomic status in the results (description of the participants' characteristics, loss of follow-up, stratification of efficacy and safety results).

Methods

We searched the following databases for randomized clinical trials published before 1st February 2022: PubMed, Scopus, Web of Science, and Excerpta Medica. We included peer-reviewed articles written in English or Spanish. Four researchers used the Rayyan platform to filter citations, first reading the title and abstract, and then accessing the full text. Articles were excluded if both reviewers agreed, or if a third reviewer decided to discard them.

Results

Sixty three articles were included, which assessed 20 different vaccines, mainly in phase 2 or 3. When describing the participants' characteristics, all the studies reported sex or gender, 73.0% race, ethnicity, 68.9% age groups, and 22.2% obesity. Only one article described the age of participants lost to follow-up. Efficacy results were stratified by age in 61.9%, sex or gender in 26.9%, race and/or, ethnicity in 9.5%, and obesity in 4.8% of the articles. Safety results were stratified by age in 41.0%, and by sex or gender in 7.9% of the analysis. Reporting of gender identity, sexual orientation or socioeconomic status of participants was rare. Parity was reached in 49.2% of the studies, and sex-specific outcomes were mentioned in 22.9% of the analysis, most of the latter were related to females' health.

Conclusions

Axes of social inequity other than age and sex were hardly reported in randomized clinical trials that assessed COVID-19 vaccines. This undermines their representativeness and external validity and sustains health inequities.
Pre-pandemic physical activity as a predictor of infection and mortality associated with COVID-19: Evidence from the National Health Insurance Service
Authors: Park Saengryeol , Kim Hyeseong , Park So-Youn , Oh In-Hwan
Published: February 2023

Introduction

During the coronavirus disease 2019 (COVID-19) pandemic, many populations have experienced reduced physical activity (PA) levels, weight gain, and increased anxiety and depression. However, according to a previous study, engaging in PA has a positive effect on damages caused by COVID-19. Therefore, this study aimed to investigate the association between PA and COVID-19 using the National Health Insurance Sharing Service Database in South Korea.

Methods

Logistic regression analysis was used to analyze the association of PA with COVID-19 and mortality. The analysis was adjusted for body mass index, sex, age, insurance type, comorbidity, and region of residence at baseline. Disability and lifestyle (weight, smoking, and drinking status) were adjusted consecutively.

Results

The results indicated that engaging in insufficient PA as per the WHO guidelines predicts a higher risk of COVID-19 when controlling for personal characteristics, comorbidity, lifestyle, disability, and mortality.

Discussion

This study revealed the need to engage in PA and manage weight to reduce the risk of infection and mortality associated with COVID-19. Because engaging in PA is an important component of weight management and can help restore physical and mental health after the COVID-19 pandemic, it should be emphasized as a pillar of recovery after COVID-19.
Human-centricity in AI governance: A systemic approach
Authors: Sigfrids Anton , Leikas Jaana , Salo-Pöntinen Henrikki , Koskimies Emmi
Published: February 2023

Human-centricity is considered a central aspect in the development and governance of artificial intelligence (AI). Various strategies and guidelines highlight the concept as a key goal. However, we argue that current uses of Human-Centered AI (HCAI) in policy documents and AI strategies risk downplaying promises of creating desirable, emancipatory technology that promotes human wellbeing and the common good. Firstly, HCAI, as it appears in policy discourses, is the result of aiming to adapt the concept of human-centered design (HCD) to the public governance context of AI but without proper reflection on how it should be reformed to suit the new task environment. Second, the concept is mainly used in reference to realizing human and fundamental rights, which are necessary, but not sufficient for technological emancipation. Third, the concept is used ambiguously in policy and strategy discourses, making it unclear how it should be operationalized in governance practices. This article explores means and approaches for using the HCAI approach for technological emancipation in the context of public AI governance. We propose that the potential for emancipatory technology development rests on expanding the traditional user-centered view of technology design to involve community- and society-centered perspectives in public governance. Developing public AI governance in this way relies on enabling inclusive governance modalities that enhance the social sustainability of AI deployment. We discuss mutual trust, transparency, communication, and civic tech as key prerequisites for socially sustainable and human-centered public AI governance. Finally, the article introduces a systemic approach to ethically and socially sustainable, human-centered AI development and deployment.
Clinical-pathological features and perioperative outcomes of mediastinoscopy vs. thoracoscopy esophagectomy in esophageal cancer: A meta-analysis
Authors: Gong Sheng , Rao Xin , Yuan Ye , Yao Xiaojun , Li Gang , Wang Ning , Li Dan , Jiang Liangshuang
Published: February 2023

Objective

To compare the clinicopathological features and perioperative outcomes of video-assisted mediastinoscopy esophagectomy (VAME) compared to video-assisted thoracoscopy esophagectomy (VATE) in esophageal cancer.

Methods

We comprehensively searched online databases (PubMed, Embase, Web of Science and Wiley online library) to find available studies exploring the clinicopathological features and perioperative outcomes between VAME and VATE in esophageal cancer. Relative risk (RR) with 95% confidence interval (CI) and standardized mean difference (SMD) with 95% CI were used to evaluate the perioperative outcomes and clinicopathological features.

Results

A total of seven observational studies and one randomized controlled trial involving 733 patients were considered eligible for this meta-analysis, of which 350 patients underwent VAME in contrast to 383 patients underwent VATE. Patients in the VAME group had more pulmonary comorbidities (RR = 2.18, 95% CI 1.37–3.46, P = 0.001). The pooled results showed that VAME shortened the operation time (SMD = −1.53, 95% CI −2.308–−0.76, P = 0.000), and retrieved less total lymph nodes (SMD = −0.70, 95% CI −0.90–−0.50, P = 0.000). No differences were observed in other clinicopathological features, postoperative complications or mortality.

Conclusions

This meta-analysis revealed that patients in the VAME group had more pulmonary disease before surgery. The VAME approach significantly shortened the operation time and retrieved less total lymph nodes and did not increase intra- or postoperative complications.
Effect of oral administration of gabapentin on the minimum alveolar concentration of isoflurane in cats
Authors: Chen Hangbin , Yang Huan , Li Mengqing , Peng Haojie , Guo Weibin , Li Meng
Published: February 2023

Objective

To determine if oral gabapentin decreases the minimum alveolar concentration (MAC) of isoflurane in cats.

Study design

Prospective, randomized, blinded, crossover, and experimental study.

Animals

A total of six healthy adult cats (three male, three female) aged 18–42 months, weighing 3.31 ± 0.26 kg.

Methods

Cats were randomly given oral gabapentin (100 mg cat−1) or placebo 2 h before starting MAC determination, with the crossover treatment given at least 7 days apart. Anesthesia was induced and maintained with isoflurane in oxygen. Isoflurane MAC was determined in duplicate using an iterative bracketing technique and tail clamp method. Hemodynamic and other vital variables were recorded at each stable isoflurane concentration and were compared between gabapentin and placebo treatments at lowest end-tidal isoflurane concentration when cats did not respond to tail clamping. A pairedt-test was used to compare normally distributed data, and a Wilcoxon signed-rank test was applied for non-normally distributed data. Significance was set atp< 0.05. Data are mean ± standard deviation.

Results

Isoflurane MAC in the gabapentin treatment was 1.02 ± 0.11%, which was significantly lower than that in the placebo treatment (1.49 ± 0.12%;p< 0.001), decreasing by 31.58 ± 6.94%. No significant differences were found in cardiovascular and other vital variables between treatments.

Conclusion and clinical relevance

Oral administration of gabapentin 2 h before starting MAC determination had a significant isoflurane MAC-sparing effect in cats with no observed hemodynamic benefit.
Algorithms in Low-Code-No-Code for Research Applications: A Practical Review
Authors: Sufi Fahim
Published: February 2023

Algorithms have evolved from machine code to low-code-no-code (LCNC) in the past 20 years. Observing the growth of LCNC-based algorithm development, the CEO of GitHub mentioned that the future of coding is no coding at all. This paper systematically reviewed several of the recent studies using mainstream LCNC platforms to understand the area of research, the LCNC platforms used within these studies, and the features of LCNC used for solving individual research questions. We identified 23 research works using LCNC platforms, such as SetXRM, the vf-OS platform, Aure-BPM, CRISP-DM, and Microsoft Power Platform (MPP). About 61% of these existing studies resorted to MPP as their primary choice. The critical research problems solved by these research works were within the area of global news analysis, social media analysis, landslides, tornadoes, COVID-19, digitization of process, manufacturing, logistics, and software/app development. The main reasons identified for solving research problems with LCNC algorithms were as follows: (1) obtaining research data from multiple sources in complete automation; (2) generating artificial intelligence-driven insights without having to manually code them. In the course of describing this review, this paper also demonstrates a practical approach to implement a cyber-attack monitoring algorithm with the most popular LCNC platform.
Model Parallelism Optimization for CNN FPGA Accelerator
Authors: Wang Jinnan , Tong Weiqin , Zhi Xiaoli
Published: February 2023

Convolutional neural networks (CNNs) have made impressive achievements in image classification and object detection. For hardware with limited resources, it is not easy to achieve CNN inference with a large number of parameters without external storage. Model parallelism is an effective way to reduce resource usage by distributing CNN inference among several devices. However, parallelizing a CNN model is not easy, because CNN models have an essentially tightly-coupled structure. In this work, we propose a novel model parallelism method to decouple the CNN structure with group convolution and a new channel shuffle procedure. Our method could eliminate inter-device synchronization while reducing the memory footprint of each device. Using the proposed model parallelism method, we designed a parallel FPGA accelerator for the classic CNN model ShuffleNet. This accelerator was further optimized with features such as aggregate read and kernel vectorization to fully exploit the hardware-level parallelism of the FPGA. We conducted experiments with ShuffleNet on two FPGA boards, each of which had an Intel Arria 10 GX1150 and 16GB DDR3 memory. The experimental results showed that when using two devices, ShuffleNet achieved a 1.42× speed increase and reduced its memory footprint by 34%, as compared to its non-parallel counterpart, while maintaining accuracy.
Aerodynamic Exploration of Corrugated Airfoil Based on NACA0030 for Inflatable Wing Structure
Authors: Zhang Qing , Xue Rongrong
Published: February 2023

The flow structures and surface pressure distributions on corrugated airfoils significantly differed from those on a conventional, smooth airfoil. An unsteady, two-dimensional computational simulation was carried out to investigate the flow behavior and associated aerodynamic performance of a group of corrugated airfoils with different levels of waviness at angles of attack from 0° to 20° with an interval of 2° at a low Reynolds number regime (Re = 1.2 × 105) and were quantitatively compared with those of its smooth counterpart. Time-averaged aerodynamic coefficients demonstrated that the corrugated airfoils have a lower lift and higher drag because of trapped vortices in the corrugations. The pressure drag of the corrugated airfoils was greater than that of the smooth airfoil. In contrast, the viscous drag of the corrugated airfoils was smaller than that of the smooth airfoil because the recirculation generated in the corrugation could reduce the viscous drag. The averaged velocity gradient in the boundary layer showed that the thickness of the boundary layer increased significantly for the corrugated airfoils because of recirculating flow caused by the small-standing vortices trapped in the valley of corrugations. The smoother the corrugated surface, the closer the aerodynamic characteristics are to those of the smooth airfoil.
The Effects of Agronomic Management in Different Tillage Systems on the Fall Growth of Winter Oilseed Rape
Authors: Szatkowski Artur , Sokólski Mateusz , Załuski Dariusz , Jankowski Krzysztof Józef
Published: February 2023

The article presents the results of a three-year study, which analyzed agronomic management in the production of winter oilseed rape (WOSR) in different tillage systems. The effects of weed control and growth regulation in fall on the number of rosette leaves, epicotyl length, root collar diameter, taproot length, rosette weight, root weight, and the overwintering success of WOSR plants in different tillage systems were determined in the study. A field experiment was conducted at the University’s Agricultural Experiment Station in Bałcyny in north-eastern Poland in three growing seasons (2016/2017–2018/2019). The experiment had a mixed 21 × 32 factorial design with two replications, where one factor was evaluated at two levels, and two factors were evaluated at three levels. The experimental factors were: A—tillage: (A0) strip-till, (A1) low-till, and (A2) conventional tillage; B—weed control: (B0) pre-emergent, (B1) foliar, and (B2) sequential; C—growth regulation: (C0) none and (C1) in fall. Winter oilseed rape plants developed rosettes with the optimal morphometric parameters in the strip-till system. Sequential and foliar application of herbicides decreased the dry matter (DM) content of leaf rosettes (by approx. 18%). The application of the growth regulator in BBCH stages 14–15 increased taproot length by 3%.
Automatic Classification of Bagworm, Metisa plana (Walker) Instar Stages Using a Transfer Learning-Based Framework
Authors: Johari Siti Nurul Afiah Mohd , Khairunniza-Bejo Siti , Shariff Abdul Rashid Mohamed , Husin Nur Azuan , Masri Mohamed Mazmira Mohd , Kamarudin Noorhazwani
Published: February 2023

Bagworms, particularly Metisa plana Walker (Lepidoptera: Psychidae), are one of the most destructive leaf-eating pests, especially in oil palm plantations, causing severe defoliation which reduces yield. Due to the delayed control of the bagworm population, it was discovered to be the most widespread oil palm pest in Peninsular Malaysia. Identification and classification of bagworm instar stages are critical for determining the current outbreak and taking appropriate control measures in the infested area. Therefore, this work proposes an automatic classification of bagworm larval instar stage starting from the second (S2) to the fifth (S5) instar stage using a transfer learning-based framework. Five different deep CNN architectures were used i.e., VGG16, ResNet50, ResNet152, DenseNet121 and DenseNet201 to categorize the larval instar stages. All the models were fine-tuned using two different optimizers, i.e., stochastic gradient descent (SGD) with momentum and adaptive moment estimation (Adam). Among the five models used, the DenseNet121 model, which used SGD with momentum (0.9) had the best classification accuracy of 96.18% with a testing time of 0.048 s per sample. Besides, all the instar stages from S2 to S5 can be identified with high value accuracy (94.52–97.57%), precision (89.71–95.87%), sensitivity (87.67–96.65%), specificity (96.51–98.61%) and the F1-score (88.89–96.18%). The presented transfer learning approach yields promising results, demonstrating its ability to classify bagworm instar stages.