bluuebunny/crossref_metadata_2025 huggingface dataset:
Anticancer Therapeutics from Insect-Derived Compounds
Authors: Jangir Suman , Kilingar Nadumane Varalakshmi
Published: August 2024

Cancer is a complex disease that leads to millions of deaths worldwide. Despite new
and improved therapeutic approaches, achieving a complete cure for the disease and protection
from its treatment side effects remains elusive. This challenge has prompted the exploration of alternative
approaches to drug discovery from natural sources, making it a top priority. Insects, as
well as their by-products, constitute a rich reservoir of amino acids, peptides, proteins, alkaloids,
fatty acids, etc., which possess various biological activities such as antibacterial, antiviral, anti-inflammatory,
antioxidant, and anticancer properties. The omnipresence of insects in nature and
their long history in folk medicine makes them suitable candidates for exploring towards anticancer
drug discovery. Among the four major orders of Class Insecta-Coleoptera, Diptera, Hymenoptera,
and Lepidoptera-there are members that have demonstrated potential anti-tumor activities.
This article provides an overview of anticancer bio-actives isolated from various insect species
belonging to the major orders of Class Insecta. These bio-actives have been analysed in vitro
and in vivo at specific levels. The diverse range of bio-actives isolated from each insect species signifies
the immense potential for discovering novel therapeutics to combat cancer. At the very
least, these compounds can be used in combination therapies. In the current review, an attempt
was made to highlight the importance of insect-derived compounds towards anticancer drug discoveries
based on the existing data gathered through literature.
Road Accidents and Safety Statistics
Authors: Muguro Joseph Kamau , Njeri Paul Waweru , Sasaki Minoru
Published: August 2024

The section provides a comprehensive overview of road accidents and safety
statistics in Kenya, emphasizing the concerning rise in fatalities and injuries in recent
years. It underscores the significant challenge posed by the lack of accurate data on
road traffic accidents (RTAs), hindering the formulation of effective solutions.
Moreover, it highlights the inadequate disaster preparedness in the country, particularly
concerning RTAs, and identifies deficiencies in policy and road monitoring strategies
as contributing factors to a culture of reckless driving. Key recommendations proposed
include the development of robust safety infrastructure, utilizing modern technology,
refining traffic laws and enforcement measures, and enhancing emergency response
and medical care capabilities. These recommendations collectively aim to address the
escalating risks associated with road accidents and foster a safer transportation
environment in Kenya.

"Transportation is the Centre of the World! It is the Glue of our Daily Lives. When it
Goes Well, we Don’t See it. When it Goes Wrong, it Negatively Colours our Day,
Makes us Angry and Impotent, Curtails our Possibilities.: — Robin Chase
Policing (Law Enforcement) and Policies on Kenyan Roads
Authors: Muguro Joseph Kamau , Njeri Paul Waweru , Sasaki Minoru
Published: August 2024

This chapter delves into the landscape of Kenyan policies and policing
activities concerning road safety, with a particular focus on the inadequacies of the
Traffic Act, road monitoring strategies, and dynamics of police-public trust. It
highlights the impediments to enforcing traffic laws (chief of which is corruption),
including ineffective monitoring strategies and prevalent criminal activities targeting
road users. Recommendations proposed involve strengthening traffic law enforcement
through resource prioritization and technological integration, enhancing collaboration
among agencies, fostering public engagement and education, and addressing criminal
activities. Through these strategies, the chapter aims to address the identified
shortcomings and promote safer roads in Kenya.

"Technology is rapidly changing our transportation systems, and if we craft smart
regulations, these changes can be for the better." -- London Breed
Conclusion and Recommendations
Authors: Muguro Joseph Kamau , Njeri Paul Waweru , Sasaki Minoru
Published: August 2024

This concluding chapter draws upon our extensive journey through Kenya's
intricate public transportation landscape. Our exploration, conducted through a
phenomenological study, aimed to unravel the lived experiences, perceptions, and
challenges faced by individuals who depend on public transportation across this diverse
nation. By adopting this unique approach, we have sought to shed light on the human
aspects of transportation issues, and in doing so, we now present our conclusions and
recommendations for a brighter future in Kenyan transportation.
Public Transportation in Kenya (A Phenomenological Study of Transport Issues)
Authors: Muguro Joseph Kamau , Njeri Paul Waweru , Sasaki Minoru
Published: August 2024

Public Transportation in Kenya provides an in-depth examination of the significant challenges faced by Kenya's public transportation system, using a phenomenological approach to highlight the real-world experiences of commuters and stakeholders. The book addresses two primary goals: to explain the severe impact of transportation issues on millions of Kenyans, including loss of livelihoods, disabilities, and fatalities, and to propose solutions aimed at reducing road traffic accidents and improving overall transportation safety.

The chapters begin with a review of Kenya's transport studies and current state, followed by an analysis of road traffic accident data and contributing factors. Subsequent sections explore the inadequacies in infrastructure, traffic law and enforcement, and the challenges posed by incomplete data collection. The book also details an innovative study using data mining and natural language processing (NLP) on over one million traffic-related tweets to uncover commuter trends and driver behaviors. The final set of chapters presents comprehensive recommendations for improving road safety, enhancing infrastructure, and reforming policing practices to better manage traffic and transportation issues.

Key features of this book include the use of both structured and unstructured data for a robust analysis, practical solutions for policymakers, and an innovative methodological approach utilizing NLP and data mining to analyze the issues presented. References and summaries are also provided in each chapter to make information accessible. These elements make the book a valuable resource for researchers, academics, policymakers, transportation professionals, and anyone interested in the socio-economic impacts of public transportation in Kenya and other African countries.

Public Transportation in Kenya is essential reading for those looking to understand and address the critical transportation challenges that affect millions daily, providing insights and solutions that can lead to safer and more efficient transport systems.
The Relationship Between Students' Attitudes Towards Violence Against Women And Their Depression
Authors: Şener Çetin Nurdilan , Yılmaz Ayşe Nur , Kargın Maral
Published: August 2024

Background: Violence against women, especially by an intimate partner in its various forms (sexual, physical, or stalking), and childhood violence (sexual or physical) are common and are associated with depressive symptoms.
Method: The sample of this descriptive-analytic research was consisted of 895 students attending to the Faculty of Health Sciences of a public university in the East of Turkey. Data were collected between October and November 2021 via the "Personal Description Form", "ISKEBE Attitudes Towards Violence Against Women Scale" and "Beck Depression Scale". Descriptive statistics, independent group t-test, Pearson correlation analysis, Chi-square, and ANOVA tests were used for statistical analysis.
Results: More than half of the students (56.1%) stated that they were exposed to violence. Verbal violence was reported to come from mothers (24.5%), fathers (20.0%) and sibling (20.2%). In addition, 23.2% of the students experienced emotional violence from their friends and 14.7% from their partners. The majority of participants indicated that an apology typically follows an act of violence as a means of restoring peace and order (28.3%). Attitude towards the body sub-dimension of ISKEBE was significantly related with the exposure to violence in general, experience of emotional and sexual violence, gender, grade and mother's educational level. Beck Depression Scale scores were significantly higher in students exposed to violence, were married, were in first grade and those under the18 years of age
Conclusion: In this study, we found that as the age of the students increased, their attitudes towards violence against women became increasingly positive. The depression score of the students who had been exposed to violence at any point in their lives was found to be higher than those who had not experienced violence. Furthermore, it was observed that while students' depression scores increased, ISKEBE scores decreased. This indicates that individuals with elevated depression scores tend to adopt a positive approach to the issue of "violence against women". Nurse educators and nurses should plan interventions to protect the mental health of nursing students and to increase their awareness of violence against women.
BUSINESS ETHICS IN INDIA AND ABROAD: AN OVERVIEW
Authors: L.P. Singh
Published: August 2024

Recent Years have witnessed a sea change in the very approach to corporate governance. Modern corporate governors do not view 'maximisation of shareholders' value' as the sole mission of corporate management. Safeguarding and protecting the interests of the crosssections of the society has come to occupy the 'central stage' of corporate planning today. This 'new-found corporate philosophy' is popularly referred to as Business Ethics in managementjargon. Of late, the coverage and scope of business ethics have started expanding by leaps and bounds. Corporate practices the world over amply bear out today that the contours of business ethics are no longer confined to an abstract do's and don'ts for business but represent a set of fundamental beliefs about the same. Observance of corporate ethics has become a global phenomenon with the US emerging as world leader. Other (developed) countries, however, donot lag far behind. Modest attempts have also been made in our country. We do have a host of socially responsible corporates: Tata group of industries providing the beacon light. Yet, we have a long way to go, particularly from the viewpoint of protecting the interests of the consumers, who are badly  unorganised even today.
NRLM PROGRAMME: PROGRESS OF WOMEN ENTREPRENEURS WITH SPECIAL REFERENCE TO VARANASI DISTRICT
Authors: Sofia Khan
Published: August 2024

A lot of research has been carried out and are being carried out for the growth and development of women in India. In light of this, the present research paper tries to study the progress of the Women Self Help Groups (WSHGs) under National Rural Livelihood Mission (NRLM) in Varanasi district. This research paper has been divided into seven sections: the
BEHAVIOR OF MARKETS AND ITS EVIDENCE TO SET PRICES: AN OUTLOOK
Authors: Indrani Sengupta
Published: August 2024

Markets, a very broader term in economics and has a wider perspective. It's an amalgamation of buyers and sellers of a product and the spread between them. The transactions for commodities may be also through letters, telegrams, telephones, internet etc. It refers to a commodity and the buyers and sellers who are in direct competition with one another. There are certain crucial structure and patterns of market that gets re
Economic Growth and Air Pollution in Metropolitan Cities of Nigeria
Authors: Harrison Charles Ekoh  , Oguche Christopher Joseph  , Samuel Gwani
Published: August 2024

There is an increasing consensus that environmental pollution has an inverted-U relationship with economic development. That is, economic development may initially lead to increased pollution but eventually bring about cleaner environment, hypothesis was also analyzed in studies using regional data within a country, and the air pollution data are from the 1999 Annual Report of Ambient Air Quality in Nigeria by the Ministry of Environment. The reason is that many of the observations are not available and are highly unreliable, mainly because those are the early years of pollution monitoring using receptors for the first time. The six metropolitan cities have 57 observation sites over 31 local districts. The results show that carbon monoxide (CO) and total suspended particulates (TSP) had inverted-U relationship with city income. The same kind of relationship, however, was not found in sulphur dioxide (SO), 2 nitrogen dioxide (NO ) and ozone (O ), it also show that SO , NO , TSP and CO have inverted-U 2 3 2 2 relationships with regional income. Turning points estimated in this paper are lower than some other particular cities of Nigeria, they estimated about 10 million won and 13 million won for SO and NO 2 2, respectively. However, the air quality data investigated in this paper are qualitatively different. Many researchers in the field of urbanair pollution report that the estimated turning points tend to be lower for the concentration data than for the emission data
Phenylketonuria—Past, Present, and Future Directions
Authors: Bailey Nicole A. , Mackay Laura
Published: August 2024

Phenylketonuria (PKU) is an autosomal recessive inborn error of metabolism with an incidence that varies throughout the world. PKU is caused by loss of function variants in the phenylalanine hydroxylase gene. This loss of function leads to the accumulation of an amino acid, phenylalanine (Phe), that can reach toxic levels in the blood. PKU is managed with a medical diet and sometimes with medication. If diagnosed early and with strict dietary control, neurocognitive deficits can be prevented. There is an important need to ensure the timely diagnosis of PKU and to develop newer therapies to treat this metabolic disorder.
Public Involvement and Engagement in Big Data Research: Scoping Review
Authors: Teodorowski Piotr , Jones Elisa , Tahir Naheed , Ahmed Saiqa , Rodgers Sarah E , Frith Lucy
Published: August 2024

Background

The success of big data initiatives depends on public support. Public involvement and engagement could be a way of establishing public support for big data research.

Objective

This review aims to synthesize the evidence on public involvement and engagement in big data research.

Methods

This scoping review mapped the current evidence on public involvement and engagement activities in big data research. We searched 5 electronic databases, followed by additional manual searches of Google Scholar and gray literature. In total, 2 public contributors were involved at all stages of the review.

Results

A total of 53 papers were included in the scoping review. The review showed the ways in which the public could be involved and engaged in big data research. The papers discussed a broad range of involvement activities, who could be involved or engaged, and the importance of the context in which public involvement and engagement occur. The findings show how public involvement, engagement, and consultation could be delivered in big data research. Furthermore, the review provides examples of potential outcomes that were produced by involving and engaging the public in big data research.

Conclusions

This review provides an overview of the current evidence on public involvement and engagement in big data research. While the evidence is mostly derived from discussion papers, it is still valuable in illustrating how public involvement and engagement in big data research can be implemented and what outcomes they may yield. Further research and evaluation of public involvement and engagement in big data research are needed to better understand how to effectively involve and engage the public in big data research.

International Registered Report Identifier (IRRID)

RR2-https://doi.org/10.1136/bmjopen-2021-050167
Creation of a New Automobile Customer Value Creation Model: The Strategic Development of Customer Science Principle
Authors: Amasaka Kakuro
Published: August 2024

This study describes a “New Automobile Customer Value Creation Model” (NA-CVCM) employing the strategic development of “Customer Science principle” (CSp) for realizing attractive cars creation based on the “Science TQM, new quality control management principle” with “Science SQC, new quality control principle”. Specifically, to strengthen “auto-corporate management”, The foundation of NA-CVCM develops a “Dual Affective Engineering”, and contains both of the “exterior design engineering strategy and driving performance design engineering strategy” through 3 domains of the “designing, manufacturing and sales marketing” employing “Strategic Stratified Task Team Model” (SSTTM) for excellent QCD activities. Concretely, by developing “Intelligent Customer Information Marketing Model” (ICIMM), the foundation of NA-CVCM consists of the “Automobile Exterior Design Model with 3 Core Methods (AECD-3CM), Automobile Optimal Product Development Design Model (AOP-DDM) and CSp-Customer Information Analysis and Navigation System (CSp-CIANS)”. The validity of NA-CVCM is then verified through the actual applications in Toyota and others.
Evaluation of Genotype –Enviroment Interactions of New Peanut Varieties Conditions of Tra Vinh
Authors: Phuoc Nguyen Trong , Phuong Le Hoang , Lang Nguyen Thi
Published: August 2024

The experiment comprised of 10 lines were laid out in a randomized block design replicated three times at 6 different locations at Dong Xuan and HeThu season from Tra Vinh . Analysis of variance indicated the presence of significant genetic variability among the genotypes for peanut under all the 6 location. All analysies of variance for the yield of peanut that were pooled over the six locations . Genotypes x Enviroment ( GxE) interactions were also found significant and the mean squares due to environment were highly significant indicating sufficient diversity among the environments. Four lines HATRI 02DP, HATRI 03DP, HATRI 14DP give hight yield both dong xuan and wet season . performed better by in all the locations both satbility at Dong Xuan and HeThu seasones. This varieties is good for multilication in the future .
Smart Irrigation System with Arduino Automation
Authors: Sreesudha P
Published: August 2024

Abstract: The main objective of the proposed system is to provide water to the plants with the help of micro controller that is automatic method. Watering to plants or gardening work can be done automatically with the aid of micro controller. Some times when we are not available in homes and going on vacation then we need to bother about our neighbours, because of watering of plants in our homes. So the proposed system solves this issue. There are several methods possible for this kind of applications. But all are not working proper. Each one fails in some stages. There are flaws in drip irrigation also. The proposed micro controller based system provides best results and solves the issues. This model uses sensor technologies with microcontroller in order to make a smart switching device to help millions of people. In its most basic form, system is programmed in such a way that soil moisture sensor which senses the moisture level from the plant. Solenoid valve will control the water flow in the system, when Arduino reads value from moisture sensor it triggers the solenoid valve according to the desired condition. In addition, system reports its current states and sends the reminder message about watering plants and gets SMS from the recipient
Li-Fi Data Transfer System
Authors: Sreesudha P.
Published: August 2024

Abstract: German physicist Harald Haas made the possibility of Li-Fi, or Light Devotion. It’s a strategy for communicating information without the need of radio waves, similar to Wi- Fi. It works by causing LEDs, which are specific lights, to streak quickly to communicate information. This happens more rapidly than our eyes can follow. Apparent light correspondence or optical remote innovations are different names for Li-Fi. This study looks at this imaginative innovation and draws correlations with Wi-Fi. Inside structures, Wi-Fi is helpful for remote information transmission. Be that as it may, Li-Fi improves; it’s faster, more effective, and more secure, and you can track down it in bunches of areas
Recent Advancements in Water Waste Water Treatment Technologies
Authors: R Spoorthy
Published: August 2024

Abstract: Water is undoubtedly the most important and invaluable natural resource that humans utilize. The main source of water for human consumption and various industrial uses on a global scale is groundwater. Different types of organic and inorganic contaminants from natural and, more often, anthropogenic sources, leach into all water systems, especially groundwater. A lack of water for human consumption is also a result of inadequate wastewater treatment, rising freshwater usage, and climate change. Therefore, it is necessary to adequately and conscientiously manage wastewater to ensure safe drinking water and sanitation for all, which is in line with Sustainable Development Goal 6 on water and sanitation (SDG 6). The systematic treatment of wastewater is carried out through three successive stages are primary (physical–chemical), secondary (biological), and tertiary (advanced physical–chemical) treatment. The primary goal of any wastewater treatment plant is to meet the legal regulations for the discharge of treated wastewater into water bodies. Currently, it is very challenging to achieve the required quality of purified wastewater, especially due to the appearance of emerging environmental pollutants. For this reason, advanced knowledge is necessary and desirable in developing new advanced technologies or improving existing technologies at all levels of wastewater treatment.
Image Plagiarism
Authors: Kumar Kollapudi Jeevan
Published: August 2024

Abstract: This project introduces an innovative approach to combat image plagiarism by developing a sophisticated detection system. By employing advanced techniques in computer vision and machine learning, our system accurately identifies instances of image replication across digital platforms. Through feature extraction and similarity measurement algorithms, trained extensively on diverse image datasets, our solution achieves high precision in detecting plagiarized content. This research aims to enhance intellectual property protection in the digital domain, promoting integrity and originality in content creation and dissemination. By contributing to the advancement of image plagiarism detection methods, this project addresses crucial challenges in preserving authenticity and attribution in digital media.
Crystallization and Flowability Process Scale-Up, a Quality by Design (QbD) Perspective: Sodium Citrate
Authors: Reddy L. Srinivasula
Published: August 2024

Abstract: Crystallization process scale‐up is extremely challenging and this credit summarizes a QbD (Quality by Design) approach for robust crystallization process development in addition to Flowability. To avoid common issues inconsistency of flowability, crystallinity of material, QbD approach has been developed for the manufacturing of Sodium citrate, which is used as excipient (pharmacologically inactive substance). To improve crystallization and flowability of material, the effect of reaction mass (RM) Temperature, effect of addition rate and time, effect of different RPM, effective of equipment selection has been studied and results discussed in this research paper.
ANÁLISE DAS ANOMALIAS DE CHUVAS ANUAIS NOS MUNICÍPIOS DE LENÇÓIS E MORRO DO CHAPÉU, CHAPADA DIAMANTINA, BAHIA, ENTRE 1980 E 2021
Authors: Rocha da Cruz Silva Priscila , Santiago Aquino Davi , Dos Santos Sanches Kimberly , Lopes Cordeiro Lilian
Published: August 2024

A Chapada Diamantina, na região central do estado da Bahia, é uma área sensível a variabilidade do volume de chuvas, pois está situada no semiárido. Por isso, algumas ferramentas estatísticas são úteis para a identificação de possíveis tendências anômalas do comportamento da precipitação pluvial. Uma dessas técnicas é o índice de anomalia de chuvas (IAC), que requer como dados de entrada apenas os valores de chuva num período considerado. Este trabalho objetivou aplicar o IAC para as chuvas anuais na Chapada Diamantina utilizando a base de dados no Instituto Nacional de Meteorologia. Foram encontradas 4 estações pluviométricas na região de estudo, mas 2 delas apresentaram quantidade insuficiente de dados. As que tiveram dados suficientes para análise estão nos municípios de Lençóis e Morro do Chapéu, cada uma com uma série de 39 anos completos. Os valores IAC para ambas estações mostraram haver uma predominância de anos de seca, notadamente nos últimos 12 anos. Para ambas as estações, os respectivos valores de IAC acumulado deram negativo, reforçando o cenário de escassez de chuvas no período considerado. Esses resultados estão de acordo com estudos similares realizados em outras regiões do nordeste brasileiro e evidenciam a necessidade de ajuste de políticas públicas regionais, para que seja considerada a sensibilidade socioeconômica da região à realidade de escassez hídrica.
Moral consumption and fujoshi fetishism among boys love (BL) series fans in Brazil
Authors: Torres Igor Leonardo de Santana
Published: August 2024

Boys love (BL) names a set of literary and audiovisual productions of male homoeroticism. Since the emergence of this genre (initially as fan texts and then as television series) there have been intense and tumultuous debates about the representation of gay men and consumption practices considered fetishistic and hypersexualizing. In the case of the Brazilian BL fandom, through the digital ethnographic method, with systematic and individual participant observation among fans, I will show that surveillance of other people’s consumption has become intrinsic to the consumption of BL series itself, a phenomenon that I call moral consumption, which involves other relations of distinction, specifically between fujoshi and non-fujoshi Brazilian fans. This differentiation produces a symbolic reductionism that is intrinsically associated with orientalist discourses and practices, which I name fujoshi fetishism, another concept that I will address in this article.
Analisis pelaksanaan asesmen portofolio di kelas V sekolah dasar
Authors: Apriliani Nisa Apriliani , Ghullam Hamdu  , Agnestasia Ramadhani Putri
Published: August 2024

The purpose of this research is to reveal and describe the implementation of portfolio assessments carried out by teachers in the learning process. Based on the literature review, this research is motivated by the suboptimal implementation of portfolio assessment. This study was conducted at SD Negeri Indihiang, with VC class teachers as participants. The study utilized a descriptive analysis method with a qualitative approach. Data were collected using interview guidelines and documentation. The study’s findings revealed several steps in compiling portfolio assessments that were not carried out: (1) the teachers did not hold regular meetings to reflect on student performance results. This is due to the teacher's difficulties in managing time to meet the demands of learning objectives; (2) the teachers did not provide continuous feedback on student work, as there was no because  selection process based on criteria; and (3) during the assessment stage, the teacher still does not use the scoring rubric, thereby unable to enforce the assessment criteria on performance results. This is due to the teachers inability to develop an assessment rubric.
Penggunaan model make a match berbantuan media pembelajaran flashcard untuk mengatasi kesulitan membaca permulaan pada siswa kelas 1 di sekolah dasar
Authors: Alvani Erta , Muharam Agus , Fajrussalam Hisny
Published: August 2024

Abstrak
Dalam kemampuan membaca siswa harus menguasai dua kemampuan tersebut yaitu, membaca nyaring dan membaca dalam hati. Salah satu kemampuan yang harus dikuasai dalam membaca adalah kemampuan membaca permulaa. Berdasarkan hasil data yang didapatkan sebelum dilakukan penelitian yang diperoleh dari guru dan siswa kelas I UPTD SDN 8 Nagrikaler, bahwa kemampuan membaca permulaan siswa tergolong rendah. Maka peneliti mencoba menggunakan model make a match berbantuan media pembelajaran flashcard dengan tujuan untuk dapat meningkatkan kesulitan membaca permulaan pada siswa kelas I. Penelitian ini dilakukan dengan menggunakan metode Penelitian Tindakan Kelas (PTK) dengan desain penelitian Kurt Lewin melalui 2 siklus. Penelitian ini dilaksanakan di UPTD SDN 8 Nagrikaler dengan subjek penelitian 26 siswa. Terdapat peningkatan pada kemampuan membaca permulaan pada siswa setelah diterapkannya model make a match berbantuan media pembelajaran flashcard. Hal ini ditunjukkan oleh hasil aktivitas dan hasil belajar siswa. Rata-rata hasil belajar kemampuan membaca permulaan pada siklus I diperoleh 70% dan siswa masih ada yang belum memperoleh nilai tuntas KKM. Siklus II diperoleh nilai rata-rata meningkat menjadi 92% dengan jumlah siswa tuntas sebanyak 24 siswa. Dengan demikian penggunaan model make a match berbantuan media pembelajaran flashacrd dapat meningkatkan kemampuan membaca permulaan pada siswa kelas I Sekolah Dasar.
 
Kata Kunci: Make a Macth, Membaca Permulaan, Flashcard
Implementasi proyek penguatan profil pelajar pancasila (P5) dalam membentuk karakter budaya di kelas IV MI Al Hikmah Tembalang
Authors: Ulfatusy Syarifah Naila , Shanie Arsan
Published: August 2024

Kehadiran profil pelajar pancasila di tengah kehidupan mampu mewujudkan tatanan dunia yang penuh kedamaian dan kasih sayang. Profil pelajar selalu mengajak untuk merealisasikan kedamaian, kebahagiaan, dan keselamatan baik di dunia maupun akhirat bagi semua golongan umat manusia, bahkan seluruh alam semesta. Profil pelajar dirancang untuk menjawab satu pertanyaan besar, yakni peserta didik dengan profil (kompetensi) seperti apa yang ingin dihasilkan oleh sistem pendidikan Indonesia. Tujuan dari penelitian ini adalah untuk memahami bentuk, upaya guru yang dilakukan, serta mengetahui kendala dalam implementasi Proyek Penguatan Profil Pelajar Pancasila (P5) dalam membentuk karakter budaya di kelas 4 MI Al Hikmah Semarang. Metode penelitian yang digunakan adalah metode kualitatif dengan pendekatan deskriptif. Dari hasil penelitian ini, dapat disimpulkan bahwa dalam Implementasi Proyek Penguatan Profil Pelajar Pancasila dalam Membentuk Karakter Budaya di Kelas 4 MI Al Hikmah Tembalang Guru di kelas IV MI Al Hikmah Tembalang Semarang berhasil membentuk karakter budaya dengan mengadakan Proyek Penguatan Profil Pelajar Pancasila. Mereka mengintegrasikan sejarah Warak Ngendok dan nilai kebudayaan dalam pelajaran, serta mendorong kerjasama dan gotong royong dalam pembuatan Warak Ngendok. Siswa mendapat pengetahuan nilai budaya dan sikap kerjasama. Faktor pendukung meliputi fasilitas dan anggaran sekolah, kedatangan guru ahli, partisipasi siswa dalam event budaya, dan dukungan lingkungan. Namun, ada hambatan seperti kurikulum baru, kurangnya pelatihan bagi guru, keterbatasan waktu, dan perbedaan karakteristik siswa
Penerapan model pembelajaran role playing untuk meningkatkan kemampuan pemahaman konsep siswa kelas IV sekolah dasar
Authors: Sopandi Meina Nurfarida , Hana Sakura Putu Arga  , Faridillah Fahmi Nurfurqon
Published: August 2024

This research has several objectives, including to find out; (1) increasing the application of the role playing learning model to students' ability to understand concepts; (2) student responses to learning using the role playing learning model; and (3) the obstacles faced by teachers in implementing learning using role playing models. The method used is a mix method with a sequential explanatory design. The research was located at Sukasari State Elementary School with research subjects of 30 class IV students. Data collection techniques through tests (pretest and posttest), observation sheets, interviews, and also questionnaires. Based on quantitative data obtained through the Ngain test, there was an increase in the ability to understand concepts in class IV students with an N-Gain score of 0.55 which was categorized as moderate. And the N-Gain Percent value is 55.7% with effective criteria. The qualitative data obtained, namely student responses, showed that the majority of students felt that the role playing model was interesting and fun, and made it easier for them to understand the material. Through interviews, the teacher revealed several obstacles, such as some students feeling less confident or reluctant to participate in role playing activities, then implementing role playing syntax requires time-consuming preparation when creating clear and interesting scenarios, and controlling the course of role playing so that it remains conducive.
Narrating Physical Diseases in the Malayan Landscape: Hugh Clifford’s “A Daughter of the Muhammadans”
Authors:   Nanyang Technological University, Singapore, Singh Tejash Kumar
Published: August 2024

Diseases such as SARS, Ebola, Covid-19, and many others have swept across the world recently at pandemic and epidemic levels. These have impacted people regardless of ethnicity, while at the same time exposing glaring inequalities in treatment, separating those who can afford medical attention from those who cannot. These inequalities are due, in the main, to social and economic factors that were abundantly laid bare in mass media coverage. In the early 20th century, by contrast, disease and its treatment served to promote the colonialist agenda, with writers using physical and psychological depictions of the colonised body’s diseases in order to advance its fabricated “othering”. Among such colonial writers was Hugh Clifford (1866-1941), Resident and Governor in Malaya during the late nineteenth and early twentieth centuries. Documenting his experiences in Malaya in his short stories, Clifford constructed particular ontological realities regarding Malayan subjects for his European audiences, promoting a fabricated perception of their “difference”. In his short story “A Daughter of the Muhammadans”, published in his 1916 collection The Further Side of Silence, Clifford investigates the visually striking corruption of leprosy, juxtaposed against the wholesome, affectionate nature of Minah, the female Malayan subject. Based on the context of medicinal advancements, I will be proposing that Clifford’s physical and psychological depictions of the Malayan body’s diseases led to its constructed “othering”, especially through the furtherance of stereotypes of the Malayan subject that are inherent in his work.
Absence as Resistance in Palestinian Speculative Fiction
Authors:   National University of Singapore, Mattar Netty
Published: August 2024

Palestinian identity is symbolic of the struggle against elimination, against becoming absent. The pervasive use of social media today has been pivotal in revealing this struggle, enabling the direct and unrestricted sharing of Palestinian suffering in the face of unremitting destruction and displacement. Across the globe, people bear witness to Palestinians fighting for survival amidst the mass bombings, field executions, and engineered famine in Israel’s current military operation in the Gaza Strip. This campaign, which began as a response to Hamas’ attack on October 7th 2023, has led to the extermination of Palestinian people at a level and pace that likely exceeds any conflict in modern history. Consequently, many experts consider this military operation a plausible genocide. Yet, despite its shocking and unfiltered nature, this recent incursion is only the latest example in a series of violent aggressions against Palestinians that have lasted nearly a century. This article aims to analyse works of speculative fiction that tackle these issues.
Cannabinoides y cáncer de mama HER2 positivo: una revisión sistemática de los estudios in vivo e in vitro
Authors:   Centro de Biociencias Clonallyx Corporation, Ecuador., Alba Naranjo Melania Nicole , Guerra Naranjo Cesar David ,   Centro de Biociencias Clonallyx Corporation, Ecuador.
Published: August 2024

El cáncer de mama comprende un trascendente enigma de salud y una de las importantes causas de mortalidad a nivel mundial. Este artículo analiza el papel de los receptores cannabinoides y sus heterómeros en el pronóstico y descubrimiento de una nueva diana terapéutica para el cáncer de mama HER2 positivo, discutiendo cannabinoides específicos para el tratamiento de cáncer de mama, esencialmente el 9-tetrahidrocannabinol (THC). El mismo que posee efectos antitumorales, induciendo a mecanismos de activación de receptores cannabinoides (CB1R y CB2R), implicación del sistema endocannabinoide (SEC), acción de ligandos endógenos y enzimas de síntesis y degradación. Se recalca la importancia de estos receptores en el área de investigación, ya que permiten un diagnóstico más preciso, tratamientos minuciosos y seguimiento de la enfermedad. Los receptores cannabinoides son sustanciales para el manejo del cáncer, ya que ponen en evidencia un nuevo mecanismo de regulación oncogénica de HER2 por medio de la heterodimerización.
PRINCIPAIS DOENÇAS NOTIFICADAS E ACOMPANHADAS PELO SISTEMA DE INFORMAÇÃO DE AGRAVOS DE NOTIFICAÇÃO (SINAN) NO PERÍODO DE 2017 A 2022 DO MUNICÍPIO DE PIRAPORA/MG
Authors: Adaskevicus Emmanuel , Ribeiro Carlos Henrique de Vasconcellos , Chaves Rodrigo
Published: August 2024

Objetivo: identificar as principais notificações compulsórias através do Sistema de Informação de Agravos de Notificação (SINAN), no período de 2017 a 2022 do município de Pirapora/MG. Materiais e Métodos: Foram dados compilados, tabulados e demonstrados de forma estatisticamente, relativo à prevalência das principais doenças de notificação compulsória. Os dados secundários anonimizados são autorizados por meio da assinatura do Termo de Cessão de Bases de Dados, pela Secretaria de Vigilância em Saúde do Ministério da Saúde (SVS/MS) no ano de 2021, e foram extraídos e disponibilizados mesmo ano. A tabulação e a análise dos dados foram realizadas utilizando-se o programa Microsoft Excel, em sua versão de 2010. No período entre a SE 1 de 2017 e a SE 52 de 2022, totalizando o valor global de 5286 notificações. Resultados: Dentre os destaques de maior relevância no período de 2017 a 2022 das 23 doenças e agravos notificados, estão os acidentes por animais peçonhentos, atendimentos antirrábicos, violência interpessoal, sífilis adquirida não especificada e intoxicações exógena. Conclusão: Dados epidemiológicos como esses, tem sua importância para que os gestores municipais façam previsões do atendimento assistencial, elaborem estratégias de prevenção para a população de risco e adotem medidas de controle.
CAPACITISMO AMBIENTAL: A (IN)JUSTIÇA CLIMÁTICA E A PESSOA COM DEFICIÊNCIA
Authors: Ferst Marklea da Cunha , Nogueira Sâmara Christina Souza , Miranda Sarah Clarimar Ribeiro de , Melo Sandro Nahmias
Published: August 2024

A preocupação científica, política e econômica sobre as mudanças climáticas está na agenda de todos os países. Prevista no Objetivo de Desenvolvimento Sustentável nº. 13 da ONU, estabelecer políticas públicas para combater as mudanças climáticas e seus impactos passa a ser um compromisso de todos os Estados-membros. Na mesma direção, a temática sobre os direitos da pessoa com deficiência ou mobilidade reduzida tem sido tema de pautas internacionais de direitos humanos. Considerando esse cenário, o objetivo dessa pesquisa foi analisar de que forma ocorre a justiça climática e o capacitismo ambiental em face das pessoas com deficiência. A metodologia aplicada foi o método dedutivo; quanto aos meios de pesquisa, utilizou-se o bibliográfico, com uso da doutrina e da legislação sobre o tema; no tocante aos fins, a pesquisa compreende-se como qualitativa. Concluiu-se que somente alguns países que aderiram ao Acordo de Paris incluem pessoas com deficiência em suas políticas de adaptação climática. Ademais, da escassez de pesquisas científicas sobre o capacitismo ambiental no Brasil, urge a necessidade de ultrapassar essa barreira que permeia as pessoas com deficiência ou mobilidade reduzida, garantindo-lhes a concretização dos princípios constitucionais basilares da igualdade e da dignidade da pessoa humana.
Reconstruction of Middle Triassic platform drowning and basin evolution of the Balaton Highland: new micropaleontological constraints
Authors: Budai Tamás , Haas János , Karádi Viktor , Vadler Emma , Tóth Emőke
Published: August 2024

Three Middle Anisian carbonate platforms (Barnag, Tagyon and Kádárta Platforms) surrounded by the hemipelagic Felsőörs Basin have been reconstructed in the Balaton Highland. The truncated surface of all platforms is covered by basinal carbonates and volcanic rocks of the Vászoly Formation. Based on conodont investigations these platforms were subject to drowning at different times. The earliest drowning was recognized in the late Pelsonian on the southern edge of the Barnag Platform (Paragondolella bulgarica Zone). This date correlates well with the opening of a neptunian dyke encountered near the southwestern margin of the Kádárta Platform and also with the age of the dykes cutting through Pelsonian platforms in the Northern Calcareous Alps, Aggtelek Hills, Dinarides and Dolomites. Drowning of the Tagyon Platform and the marginal area of the Kádárta Platform occurred in the early Illyrian (Paragondolella bifurcata and Neogondolella constricta Zones). However, the Kádárta Platform shows a trend of decreasing age for the timing of the drowning from the edge towards the inner parts of the platform during the late Illyrian. This can be explained by tectonically forced backstepping of the downfaulted marginal blocks and/or by eustatic sea-level rise accompanied by increasing volcanic activity that may have caused the decrease of transparency of the sea-water. Later on, as a result of intensifying sea level rise bathyal environment formed during the Ladinian that can be confirmed by the appearance and increasing dominance of deep-water ‘psychrosphaeric’ forms in the ostracod assemblage.
Bajocian stephanoceratid ammonites and their stratigraphy from Dorset, UK with reference to the work of András GALÁCZ
Authors: Chandler Robert
Published: August 2024

The Inferior Oolite Formation of Dorset includes Lower Bajocian strata often rich in
stephanoceratid ammonites comparable with assemblages from the rocks of the Transdanubian Central Range (W Hungary)
that are the subject of research by András Galácz, specifically Lokuticeras. In Dorset the stratigraphical occurrence of
the ‘Lokuticeras morphology’ can be traced over a range of strata from the Sauzei and Humphriesianum zones and the assemblage
composition of the biohorizons in which they occur identified. Lokuticeras is most abundant in Dorset in the uppermost Humphriesianum
and Blagdeni subzones of the Humphriesianum Zone. Specimens from three Dorset locations are figured facilitating comparison with the
Hungarian specimens. Type species Lokuticeras rossbrunnense is common at the Humphriesianum–Blagdeni subzonal transition.
A new biohorizon is erected Lokuticeras rossbrunnense nov. as the lowest biohorizon of the Blagdeni Subzone facilitating
correlating some areas of Europe. A critical review is made of previously published specimens and their affinities
First report of the Mid Barremian Event from the Transdanubian Range (Hungary) and associated Leptoceratoididae (Ammonoidea) fauna
Authors: Gőgös Gergő , Szives Ottilia
Published: August 2024

Here the distribution of criocone members of the family Leptoceratoididae that proliferated during the early and late Barremian is investigated. We attempted to identify environmental factors that may have influenced the abundance, diversity and palaeoecology of the group. Specimens of this ammonite family were found at two Hungarian localities: the Bersek Hill (Gerecse Mountains) and the Sümeg Süt-17 drill core (Southern Bakony).
Our most important stratigraphic result is the integration of stratigraphic frameworks of different autors from the Bersek Hill section which enabled us to precisely evaluate the stratigraphic distribution of this ammonite family. This integrated stratigraphy can be used with high accuracy for the Toxancyloceras vandenheckii Zone and is reliable for the Moutoniceras moutonianum Zone, but its accuracy for the lower part of the Kotetishvilia compressissima Zone is less stable. Our taxonomic analysis confirmed that Karsteniceras and Leptoceratoides should be kept as separate genera. In the Bersek Hill sections, family Leptoceratoididae is represented by Karsteniceras ibericum is the most common species found in basal K. compressissima to basal T. vandenheckii Zones. Leptoceratoides balernaensis occurs in the M. moutonianum and Leptoceratoides pumilus occurs mainly in the T. vandenheckii Zone. Their stratigraphic occurrence displays that only a few beds overlap at the top M. moutonianum Zone. In the Süt-17 borehole, the family is monospecific with L. pumilus occurrences. Unfortunately, the stratigraphic position of the Moutoniceras moutonianum Zone in Süt-17 borehole could only be inferred indirectly. Local response of Leptoceratoididae to the Mid Barremian Event shows spatial distribution patterns and resulted in different assemblage composition between the two localities. Discussion on lifestyle and paleoecology of criocone Leptoceratoididae ammonites is presented. Comparing our paleontologic findings to previously measured stable isotope data on belemnite rostra from Bersek Hill, we suggest that within the Moutoniceras moutonianum Zone, a sudden +1‰ shift in the stable carbon isotope excursion indicates the Mid Barremian Event (MBE). The -1.5‰ shift in the stable oxygen isotope excursion also indicates warming associated with rapid environmental change. During this time interval, increased organic matter entered into the Gerecse basin that could have induced increased primary productivity, hence dysoxic environment on the ocean floor. The increasing organic matter content was probably well tolerated by members of the family Leptoceratoididae and by other ammonite taxons that might have lived in the epipelagic zone, while certain groups of amonites are missing from these strata.