bluuebunny/crossref_metadata_2025 huggingface dataset:
Genome evolution following an ecological shift in nectar-dwelling
Acinetobacter
Authors: Sanchez Vivianna A. , Renner Tanya , Baker Lydia J. , Hendry Tory A.
Published: December 2024

The bacterial genus
Acinetobacter
includes species found in environmental habitats like soil and water, as well as taxa adapted to be host-associated or pathogenic. High genetic diversity may allow for this habitat flexibility, but the specific genes underlying switches between habitats are poorly understood. One lineage of
Acinetobacter
has undergone a substantial habitat change by evolving from a presumed soil-dwelling ancestral state to thrive in floral nectar. Here, we compared the genomes of floral-dwelling and pollinator-associated
Acinetobacter
, including newly described species, with genomes from relatives found in other environments to determine the genomic changes associated with this ecological shift. Following one evolutionary origin of floral nectar adaptation, nectar-dwelling
Acinetobacter
taxa have undergone reduction in genome size compared with relatives and have experienced dynamic gene gains and losses as they diversified. Gene content changes suggest a shift to metabolism of monosaccharides rather than diverse carbohydrates, and scavenging of nitrogen sources, which we predict to be beneficial in nectar environments. Gene gains appear to result from duplication events, evolutionary divergence, and horizontal gene transfer. Most notably, nectar-dwelling
Acinetobacter
acquired the ability to degrade pectin from plant pathogens, and the genes underlying this ability have duplicated and are under selection within the clade. We hypothesize that this ability was a key trait for adaptation to floral nectar, as it could improve access to nutrients in the nutritionally unbalanced habitat of nectar. These results identify the genomic changes and traits coinciding with a dramatic habitat switch from soil to floral nectar.

IMPORTANCE

Many bacteria, including the genus
Acinetobacter
, commonly evolve to exploit new habitats. However, the genetic changes that underlie habitat switches are often unknown. Floral nectar is home to specialized microbes that can grow in this nutritionally unbalanced habitat. Several specialized
Acinetobacter
species evolved from soil-dwelling relatives to become common and abundant in floral nectar. Here, we investigate the genomic adaptations required to successfully colonize a novel habitat like floral nectar. We performed comparative genomics analyses between nectar-dwelling
Acinetobacter
and
Acinetobacter
species from other environments, like soil and water. We find that although gene loss coincided with the switch to living in nectar, gains of specific genes from other bacteria may have been particularly important for this ecological change.
Acinetobacter
living in nectar gained genes for degrading pectin, a plant polysaccharide, which may improve access to nutrients in their environment. These findings shed light on how evolutionary novelty evolves in bacteria.
Anatomical insights from intraoperative OCT in microincisional trabeculectomy
Authors: Rao Aparna
Published: December 2024

The trabecular meshwork (TM) offers the maximum resistance to aqueous outflow that regulates the intraocular pressure. Newer ab interno procedures have opened up newer frontiers for understanding the functional relationship between the TM and Schlemm’s canal. This case provides newer anatomical insights from findings during intraoperative use of anterior segment optical coherence tomography during ab interno microincisional trabeculectomy. Growing evidence and intraoperative findings during ab interno trabeculectomy suggest that other parts of the TM and its intricate understanding of the physiology of the outflow pathway deserve more study.
Impact of COVID-19 on hospital visit behaviour in cancer patients in Japan: a nationwide study
Authors: Seishima Ryo , Tachimori Hisateru , Fukuda Kazumasa , Ikeda Norihiko , Miyata Hiroaki , Fushimi Kiyohide , Kitagawa Yuko
Published: December 2024

Objectives

Lockdowns and outing restrictions during the COVID-19 pandemic may have altered attitudes towards hospital visits. This study aimed to investigate changes in long-distance visits outside of secondary healthcare service areas (SHSA) among cancer patients in Japan.

Design

Retrospective observational study.

Setting

Inpatient data from the Japanese Diagnosis Procedure Combination database.

Primary and secondary outcome measures

We retrospectively analysed inpatient data from January 2018 to December 2021, extracted from the Japanese Diagnosis Procedure Combination database. The study examined whether the patient’s hospital was within their residence’s SHSA and compared the admission rates before and after the pandemic.

Results

The data of a total of 2 394 760 patients were analysed. Admission rates outside the SHSA significantly decreased after the pandemic compared with prepandemic years (26.67% and 27.58%, respectively, p<0.001). Significant reductions were observed in nearly all age groups over 30 years old, but not in younger ones. Characteristics of patients’ residences, including COVID-19 infection rates, population density and the number of regional cancer hospitals, were also influential factors. The cancer site was a significant factor, with the respiratory system showing a 3.77% decrease, particularly a 5.29% decrease in those who needed surgeries that are not highly specialised (p<0.001).

Conclusions

Admission to distant hospitals among cancer patients decreased following the COVID-19 pandemic, indicating a restraint in their behaviour of visiting distant hospitals. The appropriate allocation of specialised hospitals will serve as a measure for the next pandemic.
Efficacy and Safety of Prophylactic Agents in Prevention of Retinopathy of Prematurity: A Systematic Review and Meta-analysis of Randomised Controlled Trials
Authors: Batais Waleed T , Taher Nada O , Alhindi Abeer K , Ghaddaf Abdullah A , Alamoudi Anas , Al-Ghamdi Sarah A , Homsi Jumanah J , Almarzouki Hashem S , Qurashi Mansour A
Published: December 2024

Objective

Retinopathy of prematurity (ROP) is a leading cause of preventable childhood blindness in preterm infants with low birth weight. The efficacy and safety of prophylactic agents, including vitamin A, propranolol and lipids, in reducing ROP incidence remain unclear. This systematic review and meta-analysis evaluated the effectiveness and safety of these agents in preventing ROP.

Methods and Analysis

A systematic search was conducted in Embase, MEDLINE and CENTRAL databases. Eight randomised controlled trials involving 1101 preterm infants were included. We assessed the incidence of ROP at any stage, severe ROP, adverse events and mortality. Subgroup analyses were performed for each prophylactic agent. Data were pooled using the inverse variance weighting method and reported as risk ratios (RRs) with 95% CI.

Results

No significant reduction in ROP incidence at any stage was found in the intervention groups compared with placebo (RR=0.83; 95% CI= (0.69 to 1.00); p=0.05; I²=0%). Lipids significantly reduced severe ROP incidence (RR=0.48; 95% CI= (0.28 to 0.80); p=0.005), while vitamin A (RR=1.14; 95% CI= (0.51 to 2.54); p=0.75) and propranolol (RR=0.69; 95% CI= (0.29 to 1.65); p=0.41) did not. There were no significant differences in adverse events (RR=0.83; 95% CI= (0.59 to 1.17); p=0.28) or mortality (RR=0.93; 95% CI= (0.67 to 1.30); p=0.68) across all groups.

Conclusion

Lipids show promise in reducing severe ROP in preterm infants, while vitamin A and propranolol were not effective. Further research is needed to confirm these findings and explore the potential role of lipids in clinical practice.
Zoledronic acid as adjuvant therapy in neovascular age-related macular degeneration: a randomised controlled pilot study
Authors: Husum Yngvil Solheim , Moe Morten Carstens , Fagerland Morten Wang , Eriksen Erik Fink , Jørstad Øystein Kalsnes
Published: December 2024

Aims

To assess the feasibility of a study protocol for a randomised controlled trial of zoledronic acid (ZA) as adjuvant therapy for neovascular age-related macular degeneration (nAMD).

Methods

In this 1-year, randomised, double-blinded, placebo-controlled pilot study, nAMD patients were allocated 1:1 to receive intravenous ZA 5 mg or placebo at baseline and after 6 months in addition to intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy following a treat-and-extend regimen. Bevacizumab was the first-line anti-VEGF drug, but eyes with refractory nAMD were switched to aflibercept. The primary outcome was mean change in best-corrected visual acuity (BCVA).

Results

40 participants enrolled in the study, with 20 allocated to each treatment group. 38 participants received both study infusions, and all participants completed the final assessment. Mean (SD) change in BCVA was 7.5 (9.5) letters in the ZA group and −0.5 (11.5) letters in the control group; the between-group difference was 8.0 letters (95% CI: 1.5 to 15.0 letters). There were no between-group differences in mean change in central retinal thickness, refractory nAMD proportion or mean number of injections.

Conclusion

It is feasible to conduct a randomised controlled trial of ZA as adjuvant therapy for nAMD in terms of recruitment and adherence to the pilot study protocol. We found a possible visual benefit of ZA that is worth further investigation. To clarify the relationship between ZA and the need for intravitreal injections, we recommend amending the protocol by omitting switching of the anti-VEGF drug. Due to the limited sample size of the pilot study, the estimates of treatment effect are not meant to be confirmatory and should be interpreted with caution.

Trial registration number

2019-001492-37 (EudraCT), 04304755 (NCT).
Reaching experts for enhanced referral (REFER) to pain psychology: a modified Delphi approach with multidisciplinary paediatric pain providers at a specialised center in the USA
Authors: Schemer Lea , Harrison Lauren E , Hess Courtney W , Neville Alexandra J , Jehl Nicole , Ma Ryan S L , Glombiewski Julia A , Simons Laura E
Published: December 2024

Background

To minimise the referral gap to pain psychology, the purpose of this study was to describe clinician-perceived patient suitability for pain psychology referral, develop a referral plan and outline essential elements of a referral conversation via a modified Delphi approach with multidisciplinary paediatric pain providers.

Methods

We employed a three-round modified Delphi approach consulting multidisciplinary paediatric pain providers (n=18) including physicians, psychologists, physical therapists, occupational therapists and nurse practitioners (PT, OT, NP). Based on the responses to an online survey (Round 1), initial statements regarding the pain psychology referral process were developed. These statements were revised in three separate panels (MD panel, PSY panel, PT, OT, NP panel; Round 2). A priori consensus criteria were verified for each statement within and between groups using anonymous responses to a concluding online survey (Round 3).

Results

Approximately one-third of the statements (35%) reached consensus across all panels. For example, paediatric pain providers agreed that referrals should be communicated verbally, along with written materials, and that pain should be explained early from a biopsychosocial perspective. Paediatric pain providers also suggested minimising barriers through a flexible, stepped-care approach that adapts the delivery of pain psychology beyond traditional models. However, most statements reached consensus in only one or two panels (52%), indicating a lack of consensus across disciplines. The data suggest that it was comparatively easier to reach an overall consensus on statements formulating an ideal referral process to pain psychology (50%) than on statements characterising patient suitability (13%).

Conclusions

Paediatric pain providers developed an actionable plan for pain psychology referrals. This plan could bridge referral gaps and improve access to pain psychology treatment. Given the low provider consensus on patient suitability, further research is warranted to understand pain psychology referral decision-making, including differing perceptions of patient suitability across disciplines.
FRACTAL ANALYSIS IN ALTERNATIVE INVESTMENTS: UNVEILING DYNAMICS AND DIVERSIFICATION BENEFITS
Authors: DAWI NORAZRYANA BINTI MAT , MARESOVA PETRA
Published: December 2024

The realm of alternative investments, comprising commodities, real estate, private equity, and other non-traditional asset classes, presents a rich landscape for investors seeking diversification and enhanced returns. Amidst the complexities of these markets, fractal analysis emerges as a powerful tool for unraveling the intricate dynamics and exploring diversification benefits. This paper delves into the application of fractal theory in alternative investments, assessing its efficacy in analyzing asset price movements, correlations, and portfolio diversification. Through a comprehensive review of the literature and empirical evidence, we elucidate how fractal analysis techniques can deepen our understanding of alternative investment markets and inform strategic decision-making. Key findings highlight the ability of fractal analysis to capture nonlinear dependencies, self-similarity, and multi-scale dynamics across various asset classes. The study demonstrates how these insights enhance portfolio resilience, optimize asset allocation, and improve risk-adjusted returns. Additionally, this research contributes novel perspectives on integrating fractal methods with portfolio management and risk diversification strategies.
BIFURCATION ANALYSIS, CHAOTIC PHENOMENA, VARIATIONAL PRINCIPLE, HAMILTONIAN, SOLITARY AND PERIODIC WAVE SOLUTIONS OF THE FRACTIONAL BENJAMIN ONO EQUATION
Authors: LIANG YAN-HONG , WANG KANG-JIA
Published: December 2024

The major goal of this work is to seek the exact wave solutions, and give the bifurcation and chaotic analysis of the time-fractional Benjamin Ono equation in the conformable sense for shallow-water waves. First, the traveling wave transformation is used for the considered model and the variational principle (VP) is extracted by the semi-inverse method (SIM). Based on the VP, the Hamiltonian is derived. Applying Galilean transformation, the corresponding planar dynamical system is obtained, and the bifurcation and chaotic analysis are presented in detail. In the end, the variational method, which is based on the VP and Ritz method, and the Hamiltonian-based method are employed to develop the abundant wave solutions, including the bright solitary, dark solitary and periodic wave solutions. The graphic depictions of the obtained diverse wave solutions are presented with the aid of Maple. In the meantime, the impact of the fractional order on the structure of the extracted waveforms are elaborated. As far as we all know, the findings of this research have not been reported and can enable us to gain a deeper understanding of the nonlinear dynamics of the considered equation.
UNRAVELING FINANCIAL MARKET DYNAMICS: THE APPLICATION OF FRACTAL THEORY IN FINANCIAL TIME SERIES ANALYSIS
Authors: DAWI NORAZRYANA BINTI MAT , MATEJICEK MARTIN , MARESOVA PETRA
Published: December 2024

Financial markets are characterized by complex and often unpredictable dynamics, presenting significant challenges for investors, analysts, and policymakers. In recent years, fractal theory has emerged as a powerful tool for understanding the intricate patterns and behaviors exhibited by financial time series data. This paper provides a comprehensive review of the application of fractal theory in financial time series analysis, examining its theoretical foundations, empirical applications, and practical implications. Through a synthesis of relevant literature, we explore the utility of fractal techniques such as fractal dimension estimation, detrended fluctuation analysis (DFA), and multifractal analysis in quantifying the long-range dependence, self-similarity, and scaling properties of financial time series. Additionally, we discuss the implications of fractal dynamics for risk management, portfolio optimization, and market microstructure analysis, highlighting opportunities for future research and innovation in this evolving field.
Microscopic Malaria Infection and Its Determinants in Urban and Rural Populations Living in South‐East Gabon
Authors: Biteghe-Bi-Essone Jean-Claude , Imboumy-Limoukou Roméo Karl , Ontoua Steede-Seinnat , Atiga Nick , Mbani-Mpega Nancy , Kouna Lady Charlène , Lekana-Douki Jean Bernard , Oyegue-Liabagui Lydie Sandrine
Published: December 2024

A better understanding of malaria epidemiology in both asymptomatic and symptomatic individuals is essential for developing strategies to control the disease. This study was conducted to determine Plasmodium infection prevalence and its associated factors among people living in Franceville (urban area) and in the villages of Pana and Mvengue (rural areas) in south‐east Gabon between April and July 2022. This cross‐sectional study was conducted among all consenting residents of Franceville, Mvengue, and Pana between April and July 2022. After obtaining informed consent, Plasmodium sp. infection was screened by microscopy, and a structured questionnaire was developed to record sociodemographic data, attitudes, and practices regarding malaria. A total of 976 participants were included, with 491 in urban areas and 485 in rural areas. The overall prevalence of Plasmodium sp. infection was 21.62% (211/976; 95% confidence interval (CI) [19.15–24.31]). The prevalence was highest in children aged 6–11 years. In urban areas, the prevalence was 19.35% (95/491; 95% CI [16.10–23.07]), and 96.84% of infections were asymptomatic. The most infected age group was 18–23 years. In rural areas, the prevalence was 23.92% (116/485, 95% CI [20.34–27.91], and 93.97% (109/116) of infections were asymptomatic. Socioeconomic characteristics, attitudes, and practices towards Plasmodium sp. infection were not associated with a risk of asymptomatic malaria infection. This study highlights the importance of asymptomatic Plasmodium sp. infection in south‐east Gabon and the need for control strategies adapted to different areas and age groups. Detection and treatment of asymptomatic carriers could be an important lever for malaria control and elimination in the country.
Functional Data Clustering Based on Weighted Functional Spatial Ranks With Clinical Applications
Authors: Baragilly Mohammed , Gabr Hend , Willis Brian H.
Published: December 2024

Functional data analysis is receiving increasing attention in several scientific disciplines. However, identifying and classifying clusters of data that are essentially curves that map into an infinite dimensional space poses a significant challenge for existing methods. Here, we introduce weighted functional spatial ranks (WFSRs) as part of a nonparametric clustering approach for functional data analysis. A two‐stage or filtering method is used to approximate the curves into some basis functions and reduce the dimension of the data using functional principle components analysis (FPCA). The curves are then ranked based on WFSRs to create a contour map. This allows the visualization of the cluster structure and the size and content of each cluster to be ascertained. The effectiveness of the methods in functional data analysis is evaluated using numerical examples from simulated and two real medical datasets. Compared with several other cluster methods, the WFSR algorithm records the lowest misclassification rates over the two real datasets.
Table 1 from Beyond HRD Status: Unraveling Genetic Variants Impacting PARP Inhibitor Sensitivity in Advanced Ovarian Cancer
Authors: Kjeldsen Maj K. , Jørgensen Morten , Grønseth Dina Sofie B. , Schønemann-Lund Martin , Nyvang Gitte-Bettina , Haslund Charlotte Aaquist , Knudsen Anja Oer , Motavaf Anne Krejbjerg , Malander Susanne , Anttila Maarit , Lindahl Gabriel , Mäenpää Johanna , Dimoula Maria , Werner Theresa L. , Iversen Trine Zeeberg , Hietanen Sakari , Fokdal Lars , Dahlstrand Hanna , Bjørge Line , Birrer Michael J. , Mirza Mansoor R. , Rossing Maria
Published: December 2024

Patient characteristics
Figure 2 from Beyond HRD Status: Unraveling Genetic Variants Impacting PARP Inhibitor Sensitivity in Advanced Ovarian Cancer
Authors: Kjeldsen Maj K. , Jørgensen Morten , Grønseth Dina Sofie B. , Schønemann-Lund Martin , Nyvang Gitte-Bettina , Haslund Charlotte Aaquist , Knudsen Anja Oer , Motavaf Anne Krejbjerg , Malander Susanne , Anttila Maarit , Lindahl Gabriel , Mäenpää Johanna , Dimoula Maria , Werner Theresa L. , Iversen Trine Zeeberg , Hietanen Sakari , Fokdal Lars , Dahlstrand Hanna , Bjørge Line , Birrer Michael J. , Mirza Mansoor R. , Rossing Maria
Published: December 2024

Oncoplot showing pathogenic gene alterations. The plot is split into groups by cellular pathways affected by the alteration on the vertical axis and clinical outcome (clinical benefit: PFS ≥12 months, no benefit: PFS ≤6 months) on the horizontal axis. Each column represents one patient. In total, 81 patient samples. See color guide reflecting specific alterations below the plot. # = Reason of “end of treatment” other than progressive disease. Integer “HRD-status and GIS” = the exact GIS reported by MyChoice.
Data from Beyond HRD Status: Unraveling Genetic Variants Impacting PARP Inhibitor Sensitivity in Advanced Ovarian Cancer
Authors: Kjeldsen Maj K. , Jørgensen Morten , Grønseth Dina Sofie B. , Schønemann-Lund Martin , Nyvang Gitte-Bettina , Haslund Charlotte Aaquist , Knudsen Anja Oer , Motavaf Anne Krejbjerg , Malander Susanne , Anttila Maarit , Lindahl Gabriel , Mäenpää Johanna , Dimoula Maria , Werner Theresa L. , Iversen Trine Zeeberg , Hietanen Sakari , Fokdal Lars , Dahlstrand Hanna , Bjørge Line , Birrer Michael J. , Mirza Mansoor R. , Rossing Maria
Published: December 2024

Abstract
The management of advanced epithelial ovarian cancer (AOC) has undergone significant advancements with the emergence of molecular diagnostics, particularly in predicting responses to PARP inhibitors (PARPi) based on homologous recombination deficiency (HRD) status. However, understanding sensitivity and resistance beyond HRD status remains elusive. This study aims to explore molecular factors that may elucidate why HRD status does not consistently predict PARPi sensitivity. Therefore, we conducted a post hoc translational analysis of formalin-fixed paraffin-embedded tumor samples from the ENGOT-ov24/NSGO-AVANOVA part 1 and 2 trial (NCT02354131), focusing on alterations pertaining radiologic response and progression-free survival (PFS). DNA sequencing was performed using the TruSight Oncology 500 HT gene panel, with variants classified according to recent guidelines. HRD status had been assessed by Myriad MyChoice CDx. We identified, among 92 patients in the ENGOT-ov24/NSGO-AVANOVA part 1 and 2 trial, 151 pathogenic or likely pathogenic variants across 81 samples. PARPi-sensitizing variants were found in two out of 10 HRD-negative samples from patients with clinical benefit (PFS ≥12 months), whereas three out of 10 HRD-positive samples from patients having no benefit (PFS ≤6 months) harbored variants associated with PARPi resistance. Additionally, analysis of BRCA1 variants revealed that truncating variants in exon 11 correlated with clinical benefit when niraparib was combined with bevacizumab. Conclusively, our findings highlight the complexity of PARPi response in AOC and underscore the importance of exploring somatic variants beyond HRD status. Further investigation into exon 11 variants of BRCA1 and the potential of combination treatment is warranted.
Significance:
The irregular response to PARPi in HRD-positive and -negative tumors highlights the need for identifying additional biomarkers. This study explores the mutational landscape beyond HRD status in AOC, ultimately advancing precision oncology in future clinical practice.
Morpho-anatomical characterization and conservation status of the Whisk Fern Psilotum nudum (L.) P.Beauv. (Polypodiopsida: Psilotaceae) from Cooch Behar District of West Bengal, India
Authors: Mandal Aninda
Published: December 2024

The district Cooch Behar of West Bengal, India is considered a unique zone for pteridophytes. The Whisk Fern Psilotum nudum (Family Psilotaceae), one of the primitive members of living vascular plants considering its age of evolution during the Devonian, is reported to occur in the Cooch Behar District. The present study has been designed to investigate the current conservation status as well as to describe the morphological and anatomical features of the epiphytic species. The present study revealed that the natural falling of old aged host trees and cleaning and white painting of host tree trunks lead to habitat destruction which may lead to extinction of the species from the studied areas. During the field visits, a new site of the occurrence (Madan Mohan Temple of Cooch Behar City) of the species has also been recorded. Plants are perennial and pendent in nature. The rhizome is achlorophyllous, freely branched, and covered with rhizoids. The aerial stem is up to 36 cm long, repeatedly dichotomously branched and chlorophyllous. Leaves are scalelike, without any midrib, lanceolate to ovate, and without ligules. Synangiums are composed of three connected sporangia, bearing numerous bean-shaped spores. Stele in rhizome is haplostelic type; while, it is actinostele in the aerial stem. Morpho-anatomical description of the species has been documented for the first time from West Bengal and has enriched the botanical information of the species. Proper conservation of the taxa is utmost necessary in order to maintain their population in natural habitat.
Phycolepidozia indica (Marchantiophyta: Jungermanniales) an endemic leafless liverwort from Kerala part of Western Ghats, India
Authors: T. Krishnendhu  , C.N. Manju  , Ravi Athira  , K.P. Rajesh
Published: December 2024

The genus Phycolepidozia R.M.Schust. of the family Cephaloziellaceae is globally known by only two species, viz. P. exigua R.M.Schust., a neotropical species and P. indica Gradst., J.-P. Frahm & U. Schwarz, a southern Indian endemic species. The leafless liverwort P. indica, so far known by its type collection from Karnataka only, is being presently recorded from the Kerala part of the Western Ghats. In the present paper an illustrative account of the species is being provided.
A rare low elevation photographic record of Himalayan Serow Capricornis sumatraensis ssp. thar (Hodgson, 1831) from Nameri National Park, Assam, India
Authors: B. Piraisoodan  , Baglary Asish Immanuel , Das Saumitro , Buragohain Debasish
Published: December 2024

The Himalayan Serow Capricornis sumatraensis ssp. thar is predominantly found in middle regions of the Himalaya. During the Phase IV camera trapping protocol for 2023–24, a single sighting of this species was recorded at an unprecedented low elevation of 110 m in Nameri National Park, Assam, India. This sighting marks the first recorded presence of the Himalayan Serow in Nameri National Park. The discovery suggests potential habitat flexibility and raises questions about the species’ ecological adaptability, with important implications for its conservation.
Noteworthy records of vascular plants from the West Bank, occupied Palestinian territories
Authors: Al-Sheikh Banan , Qumsiyeh Mazin B. , Hubbieh Abdel-Salam
Published: December 2024

This study reports noteworthy data records on 23 species belonging to 19 families of vascular plants from the West Bank (occupied state of Palestine). For 15 uncommon/rare species, the newly collected data meaningfully extend their range: Saccharum spontaneum, Cyrtomium falcatum, Eleocharis palustris, Crypsis factorovskyi, Coincya tournefortii, Medicago ciliaris, Abutilon theophrasti, Anabasis oropediorum, Allium rothii, Fallopia convolvulus, Glycyrrhiza echinata, Plantago major, Pseuderucaria clavata, Lupinus palaestinus, and Cistanche violacea. Eight other species are recorded for the first time in the West Bank: Tordylium cordatum, Bergia ammannioides, Sambucus ebulus, Araujia sericifera, Euphorbia graminea, Potamogeton nodosus, Cyrtomium falcatum, and Ulmus minor. Three of those eight species (Araujia sericifera, Euphorbia graminea, and Cyrtomium falcatum) are not local in the studied region (introduced species). The fact that three of the eight new records were introduced indicates that human disturbance is becoming dominant here as elsewhere in the world. Such data are useful as Palestine is currently implementing a new National Biodiversity Strategy and Action Plan and one of its actions is focused on the conservation of rare species of plants and combatting introduced/invasive species.
Additions of two genera of liverworts (Marchantiophyta) to the bryoflora of Nagaland, India
Authors: Eshuo Kazhuhrii , Kholi Kaini  , S.K. Chaturvedi
Published: December 2024

Pseudolepicolea trollii (Herzog) Grolle & Ando and Schiffneriolejeunea tumida (Nees) Gradst. were recorded for the first time in the bryoflora of Nagaland. This also constitutes the first report of the two genera from the state. Photomicrographic details of the plants have been provided for easy identification.
Six new reports of corticioid fungi from India
Authors: Poonam  , Singh Avneet Pal , Dhingra Gurpaul Singh
Published: December 2024

The objective of the present paper is to describe and illustrate six species of corticioid fungi collected from four tehsils of the Chamba District of Himachal Pradesh (India). The described species, Brevicellicium exile (H.S.Jacks.) K.H.Larss. & Hjortstam, Kurtia magnargillacea (Boidin & Gilles) Karasiński, Physodontia lundellii Ryvarden & H.Solheim, Rhizochaete violascens (Fr.) K.H.Larss., Sistotrema coroniferum (Höhn. & Litsch.) D.P.Rogers & H.S.Jacks, and Tubulicrinis cinctus G.Cunn. are new additions to corticioid fungi reported from India.
Negative interaction or coexistence? Livestock predation and conservation of wild carnivores in Kazinag National Park and adjacent region in the Kashmir Himalaya, India
Authors: Dawood Uzma , Bhat Bilal A.
Published: December 2024

Livestock predation by wild animals poses a significant challenge to communities residing in and around protected areas. This study aimed to assess the extent and patterns of livestock predation by Asiatic Black Bears and Leopards in villages around Kazinag National Park and adjoining areas: Limber Wildlife Sanctuary, Lachipora Wildlife Sanctuary, and Naganari Conservation Reserve, in Kashmir, India. Semi-structured questionnaire surveys and interviews conducted with residents and herders camping in the study area were used to collect data on livestock predation. A total of 72 livestock kills were documented for the years 2021 and 2022, involving Leopards and Black Bears. Statistical analysis revealed significant differences in predation patterns based on age class, livestock type, time & place of events, injury pattern, and body part affected. Sheep were most frequently targeted, with total economic loss estimated at >USD 15,000. Asiatic Black Bears primarily attacked at night and preferred cattle and sheep, while Leopards targeted goats and horses, peaking in summer and late autumn. The main factors influencing predation were grazing within the park and adjacent protected areas, and poorly constructed corrals. Mitigation strategies recommended include building robust corrals and designating specific grazing zones away from core wildlife habitats. The study emphasizes the need for comprehensive, context-specific approaches to ensure the long term human-wildlife coexistence in the region.
Sightings of Red Goral Nemorhaedus baileyi in the community forest of the Upper Siang region, Arunachal Pradesh: an insight into its conservation challenges and implications within a tribal-managed landscape
Authors: Takhe Bamin  , Tekseng Kishon , Mize Daniel
Published: December 2024

A recent Sclater’s Monal survey conducted in the Upper Siang region of Arunachal Pradesh (India) resulted in the sighting of two Red Goral individuals - a young adult and a juvenile. These observations were made within the Mount Eko Dumbing area, which is owned and managed by the indigenous Simong tribal community. The report includes photographic documentation of the observed Red Gorals and provides detailed illustrations of their habitat characteristics, as well as the deep traditional relationships that the Simong people maintain with these species and the surrounding natural environment. Additionally, the study highlights the critical conservation challenges and opportunities relevant to the Red Goral in this ecologically and culturally significant region.
Pinnatella limbata (Bryophyta: Neckeraceae): reassessment of conservation status based on recent findings
Authors: O.M. Sruthi  , C.N. Manju  , K.P. Rajesh  , J. Enroth
Published: December 2024

Pinnatella limbata Dixon (Neckeraceae), a rheophytic moss species with a bistratose leaf margin unique in the genus was reported from Sampkhand in Kanara district of Karnataka State in India. The species was subsequently collected from two additional localities of Kodagu (Coorg) District in Karnataka State and that P. limbata should be removed from the threatened category of the IUCN World Red List of bryophytes due to the new information of its distribution range. The present collection from Aralam Wildlife Sanctuary, in the Kannur District of Kerala is a range extension of this species in the Western Ghats and the first report from Kerala. An attempt is made to reassess the IUCN Red List status of P. limbata.
Cardiovascular-Liver-Metabolic Health: Recommendations in Screening, Diagnosis, and Management of Metabolic Dysfunction-Associated Steatotic Liver Disease in Cardiovascular Disease via Modified Delphi Approach
Authors: Chew Nicholas W.S. , Mehta Anurag , Goh Rachel Sze Jen , Zhang Audrey , Chen Yiming , Chong Bryan , Chew Han Shi Jocelyn , Shabbir Asim , Brown Adrian , Dimitriadis Georgios K. , Huang Daniel Q. , Foo Roger , le Roux Carel W. , Figtree Gemma A. , Fudim Marat , Pandey Ambarish , Mamas Mamas A. , Hausenloy Derek J. , Richards A. Mark , Nicholls Stephen J. , Chan Mark Y. , Muthiah Mark D. , Sanyal Arun , Sperling Laurence S.
Published: December 2024

There is a new awareness of the widespread nature of metabolic dysfunction–associated steatotic liver disease (MASLD) and its connection to cardiovascular disease (CVD). This has catalyzed collaboration between cardiologists, hepatologists, endocrinologists, and the wider multidisciplinary team to address the need for earlier identification of those with MASLD who are at increased risk for CVD. The overlap in the pathophysiologic processes and parallel prevalence of CVD, metabolic syndrome, and MASLD highlight the multisystem consequences of poor cardiovascular–liver–metabolic health. Metabolic dysfunction and associated insulin resistance, together with the predilection for ectopic fat deposition in the liver and surrounding tissues, are associated with elevated risk of endothelial dysfunction, systemic inflammatory response, and ectopic fat deposition in the epicardium. This complex pathophysiology can accelerate atherogenic dyslipidemia, atherogenesis, diastolic dysfunction, valvular calcification, and cardiac arrhythmias. Despite the mounting evidence of mechanistic pathways underpinning MASLD and CVD, current recommendations have not clearly focused upon MASLD as a risk factor or target for intervention in CVD. We have brought together a diverse range of international experts committed to promoting cardiovascular–liver–metabolic health and related outcomes across the globe. The overarching goal of this document is to offer a construct for clinicians in the cardiovascular field with regards to (1) diagnosis and screening of MASLD through the use of noninvasive serum and imaging tests; (2) screening for CVD in all individuals with MASLD regardless of established atherosclerotic risk factors; and (3) the approach to management of MASLD with respect to prevention of CVD through lifestyle, as well as pharmacologic and surgical strategies. To achieve this, the modified Delphi method was applied and a series of evidence-based quality standard recommendations have been identified.
Equine-Assisted Services for Veterans with PTSD: a Meta-Analysis
Authors: Cornelius-White Jeffrey H. D. , Joyce Shea E. , Taylor Molly
Published: December 2024

Abtract

Equine-assisted psychotherapy and therapeutic riding for veterans with posttraumatic stress disorder (PTSD) has been increasingly studied but not meta-analyzed. We identified 2,609 records from database, backward (i.e., reference), and forward (i.e., citation) searches to identify 18 studies addressing effectiveness. The studies were published from 2013–2021 with sample sizes ranging from 5–85 and quality ratings medium – high. Equine-assisted services show large significant effects for change during treatment (n = 14, d = 1.156), follow-up (n = 6, d = 0.994), and compared to waitlist control (n = 1, d = 0.842), and medium effects compared to treatment-as-usual (n = 3, d = 0.465). Examination of these four types of evidence suggests promise for the use of equine-assisted services with veterans for reduction of PTSD symptomatology and a need for more controlled studies, particularly in relation to other specialized treatments also assessed as effective in treating PTSD in veterans.
Aeschynanthus chayangtajoensis (Gesneriaceae), a new species from Arunachal Pradesh, India
Authors: CHOWLU KRISHNA , SHENOY AKSHATH , RAY AJIT , KABEER ALTHAF AHAMED
Published: December 2024

Aeschynanthus chayangtajoensis, a new species of Gesneriaceae from East Kameng district of Arunachal Pradesh, India, is described and illustrated. It is morphologically similar to A. acuminatus, A. moningerae and A. pedunculatus, in habit, shape and texture of leaves, inflorescence, and seeds with single hilar appendage, but differs from all by gibbous corolla base, completely glabrous gynoecium and much smaller fruit. A detailed description of the new species with color photographs and a comparison table of similar species are provided. The new species is evaluated and provisionally assessed as ‘Critically Endangered (CR)’ according to IUCN Red List Criteria.
Assessment of the Influence of Safety Training on the Technicians Safety Culture in the Pharmaceutical Manufacturing Industries in Kenya
Authors: Miring’u Josephine , Gatebe Erastus , Karanja Benson
Published: December 2024

Introduction: Technicians in pharmaceutical manufacturing industries work in a high risk occupational setting. They are routinely exposed to chemical hazards due to the nature of their work. In order for them to perform, safety is paramount. This research intended to assess the influence of safety culture of technicians in pharmaceutical manufacturing industries. Methods: In order to achieve the objective, descriptive survey research design was used. Purposive sampling was used to select ten pharmaceutical Manufacturing industries which formed the research sample. Data was collected through questionnaires. The collected data was subjected to quantitative and qualitative analysis by use of SPSS. The results showed that the safety maturity level of 85% of the PMI’s were continually improving safety maturity level and only 15% in the involving safety maturity level. This was based on an analysis of the safety culture in four key dimensions. The study also established that majority of the respondents at 75.4% had their first encounter with OSH training at work environment commonly referred to as On the Job Training and only 23.3% were trained during their academic/professional education. The findings show that the majority of the respondents; 89.0 % and 80.8% of the respondents had been trained on the requirements of OSH Act 2007 and Evacuation procedures respectively. Notably, the training area with the least awareness was Exposure Limits of hazardous chemicals and substances at 29.1% across all PMI’s. The p values for OSH Training and Safe work documentation are p<0.001 and 0.421 respectively, indicating that OSH training is a statistically significant predictor of safety Culture. Conclusion: The hypothesis, there is statistically significant influence of training on safety culture of technicians among pharmaceutical manufacturing industries in Kenya, was accepted. Therefore we can conclude that OSH training has a significant positive influence on safety culture in pharmaceutical manufacturing industries in Nairobi, Kenya. The study therefore recommends that there is need to incorporate an OSH competency in the professional training of potential employees in the PMI’s in Kenya. This will enhance awareness of hazards and shape attitudes towards safety, well in advance hence enhance the safety culture maturity levels. The government thought the Ministry Of Labour And Social protection should ensure frameworks are able to enforce the implementation of OSHA (2007) training requirements to fill the gap in the training topic on handling of hazardous chemicals for workers in the PMI’s.
Dorobek naukowy i organizacyjny Profesor Ireny Kwileckiej
Authors: Lewaszkiewicz Tadeusz
Published: December 2024

Academic and Organisational Achievements of Professor Irena Kwilecka
Professor Irena Kwilecka focused on Old Polish lexicography and Polish translations of the Bible against the background of Slavic and other European languages. She organised research on the lexicographic works of Bartholomeus de Bydgostia and co-authored a philological edition of his dictionary (Słownik Bartłomieja z Bydgoszczy. Wersja polsko-łacińska, vol. 1–6, Warszawa 1999–2019). She also published four books devoted to partial translations of the Bible by Tomasz Łysy (Thomas the Bald) of Zbrudzewo as well as numerous studies and articles about sixteenth-century Polish translations of the Bible.
 
Dorobek naukowy i organizacyjny Profesor Ireny Kwileckiej
Profesor Irena Kwilecka zajmowała się leksykografią staropolską i polskimi przekładami Biblii na tle języków słowiańskich i innych języków europejskich. Organizowała badania nad dorobkiem leksykograficznym Bartłomieja z Bydgoszczy i jest współautorką filologicznego wydania jego słownika (Słownik Bartłomieja z Bydgoszczy. Wersja polsko-łacińska, t. 1–6, Warszawa 1999–2019). Opublikowała również cztery książki poświęcone częściowym tłumaczeniom Biblii autorstwa Tomasza Łysego ze Zbrudzewa oraz liczne opracowania i artykuły na temat szesnastowiecznych polskich przekładów biblijnych.
Два малавядомыя лацінаграфічныя тэксты з рукапісу XVIII ст.: спроба моўнай праекцыі на дыялектны ландшафт усходняй часткі Рэчы Паспалітай
Authors: Шклярык [Shkliaryk] Вадзім [Vadzim]
Published: December 2024

Two Little-Known Texts Written in the Latin Alphabet in an Eighteenth-Century Manuscript: An Attempt at Locating Them in the Dialectal Landscape of the Eastern Part of the Polish-Lithuanian Commonwealth
The article analyses a number of linguistic features of two little-known texts in the Latin alphabet under the conventional titles Krasnaia u Pani Uroda and Myleyka Swoho podkała, which are contained in an eighteenth-century manuscript from the collection of the Warsaw University Library. In one of his monographs, the Belarusian researcher Adam Malʹdzis characterised these texts as Belarusian, but in a description of the manuscript in a Polish reference book they appear as ruskie ‘Ruthenian’. The analysis of phonetic, grammatical and lexical features has shown that the texts under study could have been created in the south-western part of modern Belarus. However, it cannot be excluded that they originated in the north-west of modern Ukraine or in the neighbouring regions of Poland. This allows us to argue that the analysed texts were created in one of the territorial varieties of the language of the East Slavic population of the Polish-Lithuanian Commonwealth.
 
Dwa mało znane teksty pisane alfabetem łacińskim w XVIII-wiecznym rękopisie: próba ich językowego przyporządkowania do dialektalnego krajobrazu wschodniej części Rzeczypospolitej Obojga Narodów
W artykule przeanalizowano szereg cech językowych dwóch mało znanych, zapisanych alfabetem łacińskim tekstów pod umownymi tytułami Krasnaia u Pani Uroda i Myleyka Swoho podkała, które znajdują się w osiemnastowiecznym rękopisie ze zbiorów Biblioteki Uniwersyteckiej w Warszawie. W jednej ze swoich monografii białoruski badacz Adam Maldzis scharakteryzował te teksty jako białoruskie, ale w opisie rękopisu w jednym z polskich przewodników figurują one jako ruskie. Analiza cech fonetycznych, gramatycznych i leksykalnych wykazała, że teksty te rzeczywiście mogły powstać w południowo-zachodniej części współczesnej Białorusi, nie można jednak wykluczyć, że pochodziły z północno-zachodniej części współczesnej Ukrainy lub z sąsiednich regionów Polski. Pozwala to twierdzić, że analizowane teksty powstały w jednej z odmian terytorialnych języka ludności wschodniosłowiańskiej Rzeczypospolitej Obojga Narodów.
Między teologią a literaturą. „Locus theologicus” i jego rola w twórczości Klemensa Aleksandryjskiego na przykładzie „Wychowawcy”
Authors: Szczot Monika
Published: December 2024

Between Theology and Literature: The Locus Theologicus and Its Role in the Worksof Clement of Alexandria on the Example of the Paedagogus
This article is an attempt to describe one of the works of Clement of Alexandria (c. 150 – c. 212 AD) in the context of the role played in it by references to other literary works. Clement’s Paedagogus has a complex and hybrid structure, built on numerous quotations and allusions from Christian and pagan works. An analysis of the role of the Bible and classical literature as locus theologicus not only demonstrates the formal and genological complexity of Clement’s manual of moral theology, but also reveals its aesthetic, rhetoricaland theological aims.
 
Między teologią a literaturą. Locus theologicus i jego rola w twórczości Klemensa Aleksandryjskiego na przykładzie Wychowawcy
Głównym celem artykułu jest próba opisania jednego z utworów Klemensa Aleksandryjskiego (ok. 150 – ok. 212) w kontekście roli, jaką odgrywają w nim odwołania do innych dzieł literackich. Wychowawca Klemensa ma skomplikowaną i hybrydyczną strukturę budowaną na bazie licznych cytatów i aluzji pochodzących z dzieł chrześcijańskich i pogańskich. Analiza roli Pisma Świętego i literatury klasycznej jako „miejsca teologicznego” nie tylko pokazuje formalną i genologiczną złożoność podręcznika teologii moralnej Klemensa, lecz także ujawnia jego estetyczne, retoryczne i teologiczne cele.
Lessons Learned from Evaluating the Climate Change Risk on a Company’s Supply Chain
Authors: Gu Peng , Beck Jacklynn K. , Ding Ruixuan , Quiring Steven M.
Published: December 2024

Every economic sector in the United States is directly or indirectly impacted by weather and climate events. Although the assessment of climate change risk is not a novel concept, the majority of such assessments for individual companies are not published in the peer-reviewed literature. This makes it difficult to evaluate the robustness of these analyses and to determine best practices for effectively evaluating climate change risk at the company level. Here, we outline how we collaborated with a Fortune 500 company to assess the physical risks of climate change to their supply chain. Utilizing state-of-the-art climate models, we provide a template for developing climate change report cards and climate risk maps for all of suppliers, as well as the transportation routes between them. The purpose of these evaluations is to communicate risk to local facility managers and company leadership. By sharing our experiences, we hope that climate scientists may gain insights into quantifying and communicating climate risk to the private sector, potentially assisting them in making more informed climate adaptation decisions.