bluuebunny/crossref_metadata_2025 huggingface dataset:
Value-Based Healthcare Project Implementation in a Hierarchical Tertiary Hospital: Lessons Learned
Authors: Varela-Rodríguez Carolina , García-Casanovas Albert , Baselga-Penalva Blanca , Ruiz-López Pedro M.
Published: February 2022

An important innovation in healthcare is the value-based healthcare (VBHC) framework, a way to solve health services' sustainability problems and ensure continuous improvement of healthcare quality. The Quality and Safety Unit at the Hospital Universitario 12 de Octubre has been since May 2018 coordinating the implementation of several healthcare innovation projects within the paradigm of VBHC. Implementing innovations in a complex institution, such as a tertiary hospital, is a challenge; we present here the lessons learned in the last 4 years of work. We detail exclusively the aspects related to continuous improvement and value addition to the process. In summary, for any VBHC project implementation, we found that there are five main issues: (1) adequate data quality; (2) development of data recording and visualization tools; (3) minimizing healthcare professional's effort to record data; (4) centralize governance, coordination, and transparency policies; (5) managerial's implication and follow-up. We described six steps key to ensure a successful implementation which are the following: testing the feasibility and complexities of the entry process; establishing leadership and coordination of the project; developing patient-reported outcomes and experience measurements; developing and adapting the data recording and data analysis tools; piloting in one or more medical conditions and evaluating the results and project management. The implementation duration can vary depending on the complexity of the Medical Condition Clinical Process and Patient Pathways. However, we estimate that the implementing phase will last a minimum of 18 and a maximum of 24 months. During this period, the institution should be capable of designing and implementing the proposed innovations. The implementation costs vary as well depending on the complexity, ranging from 90,000 euros to 250,000 euros. Implementation problems included the resistance to change of institutions and professionals. To date, there are few successful, published implementations of value-based healthcare. Our quality of care and patient safety methodological approach to the implementation has provided a particular advantage.
Frequency and Associations of Adverse Reactions of COVID-19 Vaccines Reported to Pharmacovigilance Systems in the European Union and the United States
Authors: Montano Diego
Published: February 2022

Introduction

This study aims to provide a risk assessment of the adverse reactions related to the COVID-19 vaccines manufactured by AstraZeneca, Janssen, Moderna, and Pfizer-BioNTech which have been in use in the European Union and the United States between December 2020 and October 2021.

Methods

Data from the European Database of Suspected Adverse Drug Reaction (EudraVigilance) and the Vaccine Adverse Events Reporting System (VAERS) from 2020 to October 2021 are analysed. More than 7.8 million adverse reactions of about 1.6 million persons are included. The adverse reactions are classified with the Common Toxicity Criteria (CTC) categories. COVID-19 vaccine exposures and adverse reactions reported between December 2020 and October 2021 are compared to influenza vaccine exposures and adverse reactions reported between 2020 and 2021. The population-level vaccine exposures to COVID-19 and influenza vaccines comprised about 451 million and 437 million exposures, respectively. Absolute and relative risk estimates are calculated by CTC categories and COVID-19 vaccines for the EU and US populations aged 18 years and older.

Results

A higher risk of reporting serious adverse reactions was observed for the COVID-19 vaccines in comparison to the influenza vaccines. Individuals age 65 and older were associated with a higher frequency of death, hospitalisations, and life-threatening reactions than younger individuals (relative risk estimates between 1.49 99% CI [1.44–1.55] and 8.61 99% CI [8.02–9.23]). Outcome onset of serious adverse reactions occurred within the first 7 days after vaccination in about 77.6–89.1% of cases. The largest absolute risks were observed for allergic, constitutional reactions, dermatological, gastrointestinal, neurological reactions, and localised and non-localised pain. The largest relative risks between COVID-19 vs. influenza vaccines were observed for allergic reactions, arrhythmia, general cardiovascular events, coagulation, haemorrhages, gastrointestinal, ocular, sexual organs reactions, and thrombosis.

Conclusion

The present study provides an overview of adverse reactions frequently reported to the pharmacovigilance systems following COVID-19 vaccination in the EU and US populations. Despite the limitations of passive reporting systems, these results may inform further clinical research investigating in more detail the pathophysiological mechanisms potentially associated with the COVID-19 vaccines.
Disempowered Mothers Have Undernourished Children: How Strong Is the Intrinsic Agency?
Authors: Poudel Sujan , Adhikari Chiranjivi , Yadav Rajesh Kumar , Yadav Dipendra Kumar , Thapa Deependra Kaji , Jakovljevic Mihajlo
Published: February 2022

Objective

Undernutrition is one of the leading causes of morbidity and mortality among under-five children, particularly in low-and-middle-income countries. Since women, including mothers, are the primary caregivers of their children, their empowerment status can inherently influence children's nutritional status. Empowerment is, mainly, an intrinsic agency developed as an affective domain trajectory or attitude that guides the skill or behavior. This study aimed to assess the association between women's empowerment and nutritional status of their children.

Methods

A cross-sectional study was carried out among 300 mothers having children aged 6–59 month in rural municipalities of Kaski district in Nepal. Face to face interview and various anthropometric measurements were used to collect data. Chi-square test was performed to assess the association between women's empowerment and children's nutritional status, and multivariable logistic regression was used to assess the strength of association.

Results

Of 300 mothers having 6–59 months' children, nearly half (49%) were highly empowered while around 38% children were in poor nutritional status. More than one-fourth (26.7%) children were stunted, 7% were wasted, 17.7% were underweight, and in overall, nearly 38% were in poor nutrition. There was a five-fold increase in odds of wasting, thirty-fold increase in odds of stunting, and twenty-nine-fold increase in odds of underweight among children whose mothers had low empowerment status compared to their counterparts.

Conclusion

Overall, this study exhibited that maternal empowerment strongly affected children's nutritional status, especially stunting and underweight. Thus, intrinsic factor, mainly education and community membership are suggested to empower them for making their own decisions. Interventions aiming to improve nutritional status of children should include women empowerment incorporating dimensions of material resources. Further empirical evidence is required from trials and cohort studies.
A Statistical Model to Determine Biomechanical Limits for Physically Safe Interactions With Collaborative Robots
Authors: Behrens R. , Pliske G. , Umbreit M. , Piatek S. , Walcher F. , Elkmann N.
Published: February 2022

Collaborative robots (cobots) provide a wide range of opportunities to improve the ergonomics and efficiency of manual work stations. ISO/TS 15066 defines power and force limiting (PFL) as one of four safeguarding modes for these robots. PFL specifies biomechanical limits for hazardous impacts and pinching contacts that a cobot must not exceed to protect humans from serious injuries. Most of the limits in ISO/TS 15066 are preliminary, since they are based on unverified data from a literature survey. This article presents a human-subject study that provides new and experimentally verified limits for biomechanically safe interactions between humans and cobots. The new limits are specifically tailored to impact and pinching transferred through blunt and semi-sharp surfaces as they can occur in the event of human error or technical failures. Altogether 112 subjects participated in the study and were subjected to tests with emulated impact and pinching loads at 28 different body locations. During the experiments, the contact force was gradually increased until the load evoked a slightly painful feeling on the subject’s body location under test. The results confirm that the pain thresholds of males and females are different in specific body regions. Therefore, when defining biomechanical limits, the gender difference must be taken into account. A regression model was utilized to incorporate the gender effect as a covariate into a conventional statistical distribution model that can be used to calculate individual limits, precisely fitted to a specific percentile of a mixed group of male and female workers which interacting with cobots.
Malignant Lymphoproliferative Disorders of the Oral and Maxillofacial Region: Report of Two Institutions
Authors: Flores-Hidalgo Andres , Bankhead Alec , Murrah Valerie , Padilla Ricardo
Published: February 2022

Background

Report of the incidence of malignant hematologic neoplasms in the oral cavity according to the experience of the two oral and maxillofacial pathology institutions in North Carolina, USA.

Methods

A 10-year retrospective review was carried out in the records of patients at ECU SoDM and UNC Adams SoD. Age, sex, location of the lesion, clinical impression, initial diagnosis, and the expression immunohistochemical and molecular markers were recorded for each subject. All diagnoses were reviewed according to the 2016 revision of the WHO classification of lymphoid neoplasms.

Results

A total of 318 records from both institutions were reviewed. Seventy males and 68 females with an average age of 60.7 comprised the study population. The most common neoplasm encountered was plasma cell myeloma, followed by diffuse large B-cell lymphoma, B-lymphoblastic lymphoma, and follicular lymphoma. We encountered primarily intraosseous tumors, with the posterior mandible and posterior maxilla being the most common locations. Twelve cases were identified initially as a periapical radiolucency.

Conclusion

Our findings are concurrent with the existing literature regarding epidemiologic data. However, the type and location of tumors encountered do not, as the most common lymphoma in the oral cavity is diffuse large B-cell lymphoma, typically present in soft tissue. To aid in diagnosis and treatment, the collection of data should continue over time so that eventually, a more specific diagnostic profile of North Carolina residents with these neoplasms can be made.
Challenges in Access and Utilization of Sexual and Reproductive Health Services Among Youth During the COVID-19 Pandemic Lockdown in Uganda: An Online Cross-Sectional Survey
Authors: Mambo Simon Binezero , Sikakulya Franck Katembo , Ssebuufu Robinson , Mulumba Yusuf , Wasswa Henry , Mbina Solomon Adomi , Rusatira Jean Christophe , Bhondoekhan Fiona , Kamyuka Louis K. , Akib Surat Olabisi , Kirimuhuzya Claude , Nakawesi Jane , Kyamanywa Patrick
Published: February 2022

Introduction

Sexual and Reproductive Health access to Information services is still a pressing need for youth in Uganda even during the COVID-19 pandemic, which has disrupted health care access in many countries. The aim of this study was to explore the challenges in access and utilization of sexual and reproductive health services as faced by youth during the COVID-19 pandemic lockdown in Uganda.

Methods

This was a cross-sectional study carried out from 28th April 2020 to 11th May 2020 in Uganda. An online questionnaire was disseminated to youth aged between 18 and 30 years over a period of 14 days. The snowball sampling method was used to recruit participants. STATA version 14.2 was used for statistical analysis.

Results

Of 724 participants, 203 (28%) reported that they did not have access to information and/or education concerning sexual and reproductive health (SRH). More than a quarter of the participants (26.9%, n = 195) reported that testing and treatment services of sexually transmitted infections were not available during the lockdown, and 27.2% could not obtain contraceptive supplies. Access to HIV/AIDS care services and menstrual supplies was also impaired. Lack of transportation was the commonest factor cited as limiting access to SRH services during the lockdown (68.7%), followed by the long distance from home to SRH facilities (55.2%), high cost of services (42.2%) and the curfew (39.1%). Sexually transmitted infections were the commonest SRH problems related to SRH during the lockdown (40.4%) followed by unwanted pregnancy (32.4%) and sexual abuse (32.4%). Marital, educational, and employment status were significantly correlated with the reported experiences of the participants.

Conclusion

Access to SRH information and services for Ugandan youth was restricted during the COVID-19 lockdown and leaving them vulnerable to various SRH risks and adverse outcomes. Lack of transportation, long distances to health facilities, and high cost of services were important limiting factors. The Government and other stakeholders should incorporate SRH among the priority services to be preserved during future outbreaks.
Launching the Mission for 100 Climate Neutral Cities in Europe: Characteristics, Critiques, and Challenges
Authors: Shabb Katherine , McCormick Kes , Mujkic Selma , Anderberg Stefan , Palm Jenny , Carlsson Annica
Published: February 2022

The purpose of this perspective article is to critically explore the launch of the mission for 100 climate neutral cities in Europe. An overview of the mission approach in general is first presented, where key aspects and emerging critiques are identified. Second, key elements of the mission for 100 climate neutral cities in Europe are introduced along with some of its challenges and ambiguities. This perspective article ends with highlighting key emerging questions from the report “100 Climate Neutral Cities by 2030 – by and for the citizens” where research and practice need to engage to support municipalities and urban actors in efforts on climate neutrality and help to better navigate toward radical social and technical transformation. This perspective article also proposes two approaches for inclusive participation of citizens and stakeholders that can contribute to the local implementation of the mission for 100 climate neutral cities.
Which Surgeries Are the Best Choice for Chronic Pancreatitis: A Network Meta-Analysis of Randomized Controlled Trials
Authors: Mou Yu , Song Yi , Chen Hong-Yu , Wang Xing , Huang Wei , Liu Xu-Bao , Ke Neng-Wen
Published: February 2022

Background

Surgery is an effective choice for the treatment of chronic pancreatitis (CP). However, there is no clear consensus regarding the best choice among the surgical procedures. The aim of this study is to conduct a network meta-analysis of randomized controlled trials comparing treatment outcomes to provide high-quality evidences regarding which is the best surgery for CP.

Methods

A systematic search of the PubMed (MEDLINE), SCIE, EMBASE, CENTRAL, and CDSR databases were performed to identify studies comparing surgeries for CP from the beginning of the databases to May 2020. Pain relief and mortality were the primary outcomes of interest.

Results

Ten studies including a total of 680 patients were identified for inclusion. PPPD had a better postoperative short-term pain relief and quality of life (QOL), but a worse pancreatic exocrine function deficiency and high morbidity. Berne had a significant postoperative long-term pain relief and mortality with a lower risk of pancreatic exocrine function deficiency.

Conclusion

The main surgical procedures including the PPPD, Beger procedure, Frey modification and Berne modification can efficaciously treat CP. The Berne modification may be first choice with better efficacy and less complications in pancreatic function, but the impact of postoperative QOL cannot be ignored. Furthermore, when the CP patients have a mass in the pancreatic head which cannot be distinguished from pancreatic cancer, the only legitimate choice should be PPPD or classical pancreaticoduodenectomy.
Neonatal Surgical Morbidity and Mortality at a Single Tertiary Center in a Low- and Middle-Income Country: A Retrospective Study of Clinical Outcomes
Authors: Hasan Md Samiul , Islam Nazmul , Mitul Ashrarur Rahman
Published: February 2022

Background

The most challenging and demanding issue in Pediatrics and Pediatric Surgery is to deal with neonatal surgery which almost always involves emergency neonatal surgical conditions. Emergency neonatal surgery most often involves congenital anomalies. More than 90% of these anomalies occur in low- and middle-income countries (LMICs) like Bangladesh. This considerable load of patients and inadequate resources in their management continue to be an unconquerable challenge for pediatric and neonatal surgeons in this region. We aim to review the challenges and constraints influencing the outcomes of emergency neonatal surgery which will guide to propose expectations from the global community.

Method

We reviewed hospital records of neonates admitted to a tertiary care pediatric hospital between January 2016 and December 2020. Demographic and clinical data were extracted using a questionnaire and analyzed using SPSS 25.

Results

A total of 3,447 neonates were admitted during the five-year study period. More than 80% of the patients had at least one prenatal ultrasonography (USG) scan, but less than 10% had a prenatal diagnosis. More than 70% of the anomalies of the patient involved the gastrointestinal tract and abdominal wall. Overall mortality was an alarming 14.6%. Gastroschisis (>90%) and esophageal atresia (>85%) mainly contributed to this high mortality. The challenges detected in this review were the absence of a prenatal diagnosis, limited access to intensive care facilities, unavailability of parenteral nutrition, inadequate monitoring, and hospital-acquired sepsis.

Conclusion

Emergency neonatal surgery contributes to a significant proportion of neonatal mortality. A holistic approach is essential to improve the situation, including the infrastructure and human resource development, identification of causes, and implementation of preventive measures to reduce the patient load. Global collaboration remains to be a vital factor to mitigate these multifactorial constraints.
Live Recombinant NDV-Vectored H5 Vaccine Protects Chickens and Domestic Ducks From Lethal Infection of the Highly Pathogenic H5N6 Avian Influenza Virus
Authors: Lee Jiho , Kim Deok-hwan , Noh Jinyong , Youk Sungsu , Jeong Jei-hyun , Lee Joong-bok , Park Seung-Yong , Choi In-soo , Lee Sang-Won , Song Chang-seon
Published: February 2022

The H5 subtype highly pathogenic avian influenza virus (HPAIV) has been introduced to South Korea every 2 or 3 years via wild migratory waterfowls, causing devastating damages to the poultry industry. Although most damages and economic losses by HPAIV are focused on chicken layers, domestic ducks are known to play a major role in the farm-to-farm transmission. However, most HPAIV vaccine studies on poultry have been performed with oil-emulsion inactivated vaccines. In this study, we developed a live recombinant Newcastle disease virus (NDV)-vectored vaccine against H5 HPAIV (rK148/ES2-HA) using a previously established NDV vaccine strain (K148/08) isolated from a wild mallard duck. The efficacy of the vaccine when administered via the oculonasal route or as a spray was evaluated against lethal H5 HPAIV infection in domestic ducks and chickens. Oculonasal inoculation of the rK148/ES2-HA in chickens and ducks elicited antibody titers against HPAIV as early as 1 or 2 week after the single dose of vaccination, whereas spray vaccination in ducks elicited antibodies against HPAIV after the booster vaccination. The chickens and ducks vaccinated with rK148/ES2-HA showed high survival rates and low viral shedding after H5N6 HPAIV challenge. Collectively, vaccination with rK148/ES2-HA prevented lethal infection and decreased viral shedding in both chickens and ducks. The vaccine developed in this study could be useful in suppressing the viral shedding in H5 HPAIV outbreaks, with the ease of vaccine application and fast onset of immunity.
Differentiation of Subclinical Ketosis and Liver Function Test Indices in Adipose Tissues Associated With Hyperketonemia in Postpartum Dairy Cattle
Authors: Mohsin Muhammad Ali , Yu Huiru , He Rongze , Wang Peng , Gan Linli , Du Yulan , Huang Yunfei , Abro Muhammad Bakhsh , Sohaib Sarmad , Pierzchala Mariusz , Sobiech Przemysław , Miętkiewska Klaudia , Pareek Chandra S. , He Bao Xiang
Published: February 2022

Past studies suggested that during early lactation and the transition period, higher plasma growth hormone (GH) levels in subclinical ketosis (SCK) might involve the initiation of body adipose tissues mobilization, resulting in metabolic disorders in ruminants particularly hyperketonemia. The upregulated GH mRNA expression in adipose tissue may take part in the adipolysis process in SCK-affected cows that paves a way for study further. This study aimed to characterize the plasma levels of GH, β-hydroxybutyrate acid (BHBA) and non-esterified fatty acid (NEFA) and glucose (GLu) in ketotic cows and healthy control (CON) cows; to measure the liver function test (LFT) indices in ketotic and healthy CON cows, and finally the quantitative real-time PCR (qRT-PCR) assay of candidate genes expressed in adipose tissues of ketotic and healthy CON cows during 0 to 7 week postpartum. Three experiments were conducted. Experiment-1 involved 21 Holstein cows weighing 500–600 kg with 2–5 parities. Results showed that GH, BHBA, and NEFA levels in ketotic cows were significantly higher and the GLu level significantly lower. Pearson's correlation analysis revealed a significant positive correlation of GH with BHBA, NEFA, and GLu in ketotic and healthy CON cows. In experiment-2, dynamic monitoring of LFT indices namely, alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyl transpeptidase (GGT), total bilirubin (TBIL), direct bilirubin (DBIL), total protein (TP), albumin (ALB), globulin (GLOB) and albumin/globulin (A/G) were examined. The TBIL, DBIL, and GGT indices were significantly higher in ketotic cows and TP was significantly lower. In experiment-3, mRNA expression levels of GHR and peroxisome-proliferator-activated receptor alpha (PPARα) genes in adipose tissue were significantly upregulated in ketotic cows. However, the mRNA expression of insulin-like growth factor-I (IGF-1), insulin-like growth factor-I receptor (IGF-1R), and sterol regulatory element-binding protein-1c (SREBP-1c) genes in adipose tissue were downregulated in ketotic cows. Our study concluded that during postpartum, higher plasma GH levels in SCK cows might involve the initiation of body adipose tissue mobilization, resulting in hyperketonemia.
Case Report: Imaging Features and Successful Management of Ureteral Stenosis in a Kitten With Bilateral Atypical Papillary Transitional Mucosal Hyperplasia
Authors: Kwon Minji , Kim Sungsoo , Lee Kichang , Yoon Hakyoung
Published: February 2022

A 3-month-old cat weighing 2.62 kg was brought to the VIP Animal Medical Center with vomiting, diarrhea, anorexia, and depression. Laboratory findings confirmed azotemia with elevated blood urea nitrogen (BUN) (168.9 mg/dl) and creatinine (5.9 mg/dl) and symmetric dimethylarginine (SDMA) (86 μg/dl). Abdominal radiography revealed bilateral renomegaly. Ultrasonography revealed bilateral hydronephrosis and left partial and right complete ureteral obstructions with bilateral focal irregular and circumferential thickenings at ureters. Reduction of bilateral renal function was confirmed through excretory urography on computed tomography. The cat underwent subcutaneous ureteral bypass surgery on the left kidney, right nephrectomy, and bilateral ureterectomy. Histopathology of bilateral ureteral irregular and circumferential thickening revealed bilateral atypical papillary transitional mucosal hyperplasia. Three days after surgery, the left hydronephrosis resolved, and azotemia was almost resolved. This is the first report of successful management of ureteral stenosis with congenital papillary transitional mucosal hyperplasia in a kitten using multimodality imaging.
Calcium Homeostasis and Bone Metabolism in Goats Fed a Low Protein Diet
Authors: Mi Hui , Li Haobang , Jiang Weimin , Song Wu , Yan Qiongxian , He Zhixiong , Tan Zhiliang
Published: February 2022

The objective of this study was to investigate the effects of low-protein diets on blood calcium (Ca) level, bone metabolism, and the correlation between bone metabolism and blood calcium in goats. Twenty-four female Xiangdong black goats with similar body weight (19.55 ± 3.55 kg) and age (8.0 ± 0.3 months) were selected and allocated into two groups: control group (CON, 10.77% protein content) and low-protein group (LP, 5.52% protein content). Blood samples were collected on days 1, 4, 7, 16 and 36 before morning feeding to determine the concentration of calcium (Ca), parathyroid hormone (PTH), bone gla protein (BGP), C-terminal telopeptide of type 1 collagen (CTX-1), bone alkaline phosphatase (BALP), and 1, 25-dihydroxyvitamin D3 [1,25(OH)2D3]. Liver samples were collected to determine the expression of bone metabolism-related genes. There was no difference observed between LP and CON in concentration of plasma Ca or any of bone metabolism markers (P > 0.05). In the liver, the mRNA expression of bone gamma carboxyglutamate protein (BGLAP), alkaline phosphatase (ALPL), and mothers against decapentaplegic homolog-1 (SMAD1) were increased (P < 0.05) in LP as compared with CON. The correlation analysis of Ca and bone metabolism markers showed no significant correlation between Ca and bone metabolism. These results suggest that the blood Ca concentration in mature goats may keep at a stable level through nitrogen cycling when the providing protein is not enough.
Experimental Study of Dynamical Airfoil and Aerodynamic Prediction
Authors: Shi Zheyu , Zhou Kaiwen , Qin Chen , Wen Xin
Published: February 2022

Dynamic stall is a critical limiting factor for airfoil aerodynamics and a challenging problem for active flow control. In this experimental study, dynamic stall was measured by high-frequency surface pressure tapes and pressure-sensitive paint (PSP). The influence of the oscillation frequency was examined. Dynamic mode decomposition (DMD) with time-delay embedding was proposed to predict the pressure field on the oscillating airfoil based on scattered pressure measurements. DMD with time-delay embedding was able to reconstruct and predict the dynamic stall based on scattered measurements with much higher accuracy than standard DMD. The reconstruction accuracy of this method increased with the number of delay steps, but this also prolonged the computation time. In summary, using the Koopman operator obtained by DMD with time-delay embedding, the future dynamic pressure on an oscillating airfoil can be accurately predicted. This method provides powerful support for active flow control of dynamic stall.
Sustainable Entrepreneurs of the Future: The Interplay between Educational Context, Sustainable Entrepreneurship Competence, and Entrepreneurial Intentions
Authors: Joensuu-Salo Sanna , Viljamaa Anmari , Varamäki Elina
Published: February 2022

The aim of this paper is to understand how sustainable entrepreneurship competence impacts entrepreneurial intentions in two educational contexts: in higher education and in secondary education. We applied the sustainable entrepreneurship framework, which includes six competencies of sustainable entrepreneurship, and the Theory of Planned Behavior. The data were gathered from seven European countries and consist of 486 responses from higher education students and 642 responses from secondary-level students. The results show that sustainable entrepreneurship competence (SEC) is a significant factor that can explain entrepreneurial intentions. It has a significant direct effect on entrepreneurial intentions in both educational contexts. Perceived behavioral control (PBC) moderates the relationship between SEC and entrepreneurial intentions; the effect of SEC decreases when PBC increases. The moderating effect was found only with higher education students, not with secondary-level students. This study demonstrates a connection between sustainable entrepreneurship competence and entrepreneurial intentions and contributes to a better understanding of the role of sustainable entrepreneurship competence in shaping students’ aspirations for an entrepreneurial career in different educational contexts.
Analysis of Growth Characteristics of Kimchi Cabbage Using Drone-Based Cabbage Surface Model Image
Authors: Go Seung-Hwan , Lee Dong-Ho , Na Sang-Il , Park Jong-Hwa
Published: February 2022

Cultivation soil is the basis for cabbage growth, and it is important to assess not only to provide information on how it affects the growth of vegetable crops but also for cultivation management. Until now, field cabbage surveys have measured size and growth variations in the field, and this method requires a lot of time and effort. Drones and sensors provide opportunities to accurately capture and utilize cabbage growth and variation data. This study aims to determine the growth stages based on drone remote estimation of the cabbage height and evaluate the impact of the soil texture on cabbage height. Time series variation according to the growth of Kimchi cabbage exhibits an S-shaped sigmoid curve. The logistic model of the growth curve indicates the height and growth variation of Kimchi cabbage, and the growth rate and growth acceleration formula of Kimchi cabbage can thus be derived. The curvature of the growth parameter can be used to identify variations in Kimchi cabbage height and its stages of growth. The main research results are as follows. (1) According to the growth curve, Kimchi cabbage growth can be divided into four stages: initial slow growth stage (seedling), growth acceleration stage (transplant and cupping), heading through slow growth, and final maturity. The three boundary points of the Kimchi cabbage growth curve are 0.2113 Gmax, 0.5 Gmax, and 0.7887 Gmax, where Gmax is the maximum height of Kimchi cabbage. The growth rate of cabbage reaches its peak at 0.5 Gmax. The growth acceleration of cabbage forms inflection points at 0.2113 Gmax and 0.7887 Gmax, and shows a variation characteristic. (2) The produced logistic growth model expresses the variation in the cabbage surface model value for each date of cabbage observation under each soil texture condition, with a high degree of accuracy. The accuracy evaluation showed that R2 was at least 0.89, and the normalized root-mean-square error (nRMSE) was 0.09 for clay loam, 0.06 for loam, and 0.07 for sandy loam, indicating a very strong regression relationship. It can be concluded that the logistic model is an important model for the phase division of cabbage growth and height variation based on cabbage growth parameters. The results obtained in this study provide a new method for understanding the characteristics and mechanisms of the growth phase transition of cabbage, and this study will be useful in the future to extract various types of information using drones and sensors from field vegetable crops.
Seed Treatment with Iron Chlorine E6 Enhances Germination and Seedling Growth of Rice
Authors: Xie Yali , Wei Lihui , Ji Yinghua , Li Shuo
Published: February 2022

Iron chlorine e6 (ICE6), also known as iron dihydroporphine, is a new type natural plant growth regulator, which can improve some crops growth. At present, the effects of ICE6 on rice are still unclear. Therefore, it is of great significance to study the effect of ICE6 on rice growth. In this study, the effect of seed treatment with ICE6 on rice germination and seedling growth was evaluated. Rice seeds were soaked with the gradient concentration and gradient time of ICE6, respectively, and then the germination rate, growth indexes and chlorophyll content of rice were determined. The results showed seed soaking with ICE6 could improve rice seed germination, promote seedling growth and increase the chlorophyll content in plants, exhibiting a better growth promoting effect. The optimum soaking condition was 100–200 mg/L (concentration) and 24–48 h (time). The field experiment further verified the growth regulating effect of ICE6 priming on rice seedlings. After seed priming with ICE6, seed vigor became higher, and the activities of α-amylase and protease in germinating seeds increased. The increase of seed vigor might be an important reason that ICE6 improved the germination and seedling growth. In addition, we also found ICE6 treatment could enhance the regeneration ability of seedlings. This work demonstrated the germination and growth promoting effect of ICE6 on rice, and revealed its application potential in rice production. This seed priming technique was of great promotional value in the field.
Soil Compaction from Wheel Traffic under Three Tillage Systems
Authors: Acquah Kobby , Chen Ying
Published: February 2022

Agricultural fields are usually subjected to high amounts of traffic from field operations. The influence of traffic on sandy loam soil in three tillage systems were investigated in a field experiment. The field was located in a Canadian prairie region. In the experiment, the treatments were three tillage systems: no-tillage, disc tillage, and spring-tine tillage. Following tillage operations, field plots were trafficked with one pass of a sub-compact tractor. Soil properties were measured before and after the traffic to examine the effects of tillage systems and wheel traffic. For the effects of the tillage systems on the soil bulk density, soil shear strength, soil surface resistance, and soil cone index, the no-tillage system had higher values for all the soil properties when compared with the disc and spring-tine tillage systems. The plant (canola) population density ranged from 18.2 plants/m2 to 34.9 plants/m2, with the no-tillage having the lowest plant densities. For the effects of wheel traffic, one pass of the tractor in the disc and spring-tine tillage plots resulted in a 2.7% and 17.4% reduction in soil moisture content, respectively. After wheel traffic, the average soil shear strength for the disc and spring-tine systems were still significantly lower than the no-tilled system. Sinkages of 40 and 50 mm were observed for the spring-tine and disc tillage systems, respectively. The results of this study highlight the importance of preventing the demerits of soil compaction induced by wheel traffic after tillage operations.
Aroma Volatiles in Tomato Fruits: The Role of Genetic, Preharvest and Postharvest Factors
Authors: Distefano Miriam , Mauro Rosario Paolo , Page David , Giuffrida Francesco , Bertin Nadia , Leonardi Cherubino
Published: February 2022

Over the last few decades, the improvement of tomato aroma and flavour has gained growing attention among breeders, agronomists and food technologists, as it is reputed as a key tool to further consolidate tomato consumption in the global market. However, this represents a difficult task, since more than 400 volatile organic compounds (VOCs) differently contribute to tomato aroma and its flavour perception. The recent development of molecular tools has allowed us to identify some of the major alleles influencing the volatile composition of tomatoes. Nonetheless, such composition involves an intricate weave of polygenic systems, highly influenced by external, pre and postharvest factors. With few exceptions, our knowledge about the effects of these determinants is still scarce, making it difficult to draw sound conclusions to best manage the future genetic potential. The present review examines the existing knowledge on major VOCs influencing tomato organoleptic quality, including their classification, metabolic pathways, genetics, and technical features that affect their concentrations in fruits. Particular emphasis is placed on preharvest and postharvest factors influencing their quantitative and qualitative expression, whose integrated study with omic tools will be increasingly necessary for the perspective of disseminating reliable operational indications throughout the production/distribution chain.
Carbon, Nitrogen and Water Footprints of Organic Rice and Conventional Rice Production over 4 Years of Cultivation: A Case Study in the Lower North of Thailand
Authors: Arunrat Noppol , Sereenonchai Sukanya , Chaowiwat Winai , Wang Can , Hatano Ryusuke
Published: February 2022

An integrated method is required for comprehensive assessment of the environmental impacts and economic benefits of rice production systems. Therefore, the objective of this study was to apply different footprinting approaches (carbon footprint (CF), nitrogen footprint (NF), water footprint (WF)) and determine the economic return on organic rice farming (OF) and conventional rice farming (CVF) at the farm scale. Over the 4-year study period (2018–2021), the results showed lower net greenhouse gas (GHG) emissions in OF (3289.1 kg CO2eq ha−1 year−1) than in CVF (4921.7 kg CO2eq ha−1 year−1), indicating that the use of OF can mitigate the GHG emissions from soil carbon sequestration. However, there was a higher CF intensity in OF (1.17 kg CO2eq kg−1 rice yield) than in CVF (0.93 kg CO2eq kg−1 rice yield) due to the lower yield. The NF intensities of OF and CVF were 0.34 and 11.94 kg Neq kg−1 rice yield, respectively. The total WF of CVF (1470.1 m3 ton−1) was higher than that in OF (1216.3 m3 ton−1). The gray water in CVF was significantly higher than that in OF due to the use of chemical fertilizers, herbicides, and pesticides. Although the rice yield in OF was nearly two times lower than that in CVF, the economic return was higher due to lower production costs and higher rice prices. However, more field studies and long-term monitoring are needed for future research.
Comparison of Methane Emission Patterns from Dairy Housings with Solid and Slatted Floors at Two Locations
Authors: Hempel Sabrina , Janke David , Losand Bernd , Zeyer Kerstin , Zähner Michael , Mohn Joachim , Amon Thomas , Schrade Sabine
Published: February 2022

Methane (CH4) emissions from dairy husbandry are a hot topic in the context of active climate protection, where housing systems with slatted floors and slurry storage inside are in general expected to emit more than systems with solid floors. There are multiple factors, including climate conditions, that modulate the emission pattern. In this study, we investigated interrelations between CH4 emission patterns and climate conditions as well as differences between farm locations versus floor effects. We considered three data sets with 265, 264 and 275 hourly emission values from two housing systems (one slatted, one solid floor) in Switzerland and one system with solid floors in Germany. Each data set incorporated measurements in summer, winter and a transition season. The average CH4 emission was highest for the slatted floor system. For the solid floor systems, CH4 emissions at the Swiss location were around 30% higher compared to the German location. The shape of the distributions for the two solid floor systems was rather similar but very different from the distribution for the slatted floor system, which showed higher prevalence for extreme emissions. Rank correlations, which measure the degree of similarity between two rankings in terms of linear relation, were not able to detect dependencies at the selected significance level. In contrast, mutual information, which measures more general statistical dependencies in terms of shared information, revealed highly significant dependencies for almost all variable pairs. The weakest statistical relation was found between winds speed and CH4 emission, but the convection regime was found to play a key role. Clustering was consistent among the three data sets with five typical clusters related to high/low temperature and wind speed, respectively, as well as in some cases to morning and evening hours. Our analysis showed that despite the disparate and often insignificant correlation between environmental variables and CH4 emission, there is a strong relation between both, which shapes the emission pattern in many aspects much more in addition to differences in the floor type. Although a clear distinction of high and low emission condition clusters based on the selected environmental variables was not possible, trends were clearly visible. Further research with larger data sets is advisable to verify the detected trends and enable prognoses for husbandry systems under different climate conditions.
Aquaporins and Animal Gamete Cryopreservation: Advances and Future Challenges
Authors: Ribeiro João C. , Carrageta David F. , Bernardino Raquel L. , Alves Marco G. , Oliveira Pedro F.
Published: February 2022

Cryopreservation is globally used as a method for long-term preservation, although freeze-thawing procedures may strongly impair the gamete function. The correct cryopreservation procedure is characterized by the balance between freezing rate and cryoprotective agents (CPAs), which minimizes cellular dehydration and intracellular ice formation. For this purpose, osmoregulation is a central process in cryopreservation. During cryopreservation, water and small solutes, including penetrating cryoprotective agents, cross the plasma membrane. Aquaporins (AQPs) constitute a family of channel proteins responsible for the transport of water, small solutes, and certain gases across biological membranes. Thirteen homologs of AQPs (AQP0-12) have been described. AQPs are widely distributed throughout the male and female reproductive systems, including the sperm and oocyte membrane. The composition of the male and female gamete membrane is of special interest for assisted reproductive techniques (ART), including cryopreservation. In this review, we detail the mechanisms involved in gamete cryopreservation, including the most used techniques and CPAs. In addition, the expression and function of AQPs in the male and female gametes are explored, highlighting the potential protective role of AQPs against damage induced during cryopreservation.
Developing ‘Smart’ Dairy Farming Responsive to Farmers and Consumer-Citizens: A Review
Authors: Henchion Maeve Mary , Regan Áine , Beecher Marion , MackenWalsh Áine
Published: February 2022

Innovation has resulted in more dairy products being produced with less inputs than ever before. It has also affected how animals are raised, the structure of the sector and the nature of products produced. Not all impacts have been positive. As disruptive technologies—such as precision farming and robotics—herald significant change, it is timely to reflect on the perspectives of different actors on innovations within the sector. Drawing on a review of academic literature, this paper considers farmers’ and consumer-citizens’ perspectives; as expected, their diverse knowledge, interests and values surface a range of perspectives. To provide focus to the study, it examines technologies across three stages of the dairy production cycle: breeding, feeding and milking. It finds that consumer-citizen and farmer perspectives have been examined by researchers in several countries, using a variety of methods, across a range of technologies. It finds both areas of agreement and tension within and between consumer-citizen and producer cohorts. While differences in knowledge account for some variation, differences in values are also significant. The extent to which efforts can and should be put into addressing differences is raised as a point for reflection.
European Turtle Dove Population Trend in Greece Using Hunting Statistics of the Past 16-Year Period as Indices
Authors: Thomaidis Christos , Papaspyropoulos Konstantinos G. , Karabatzakis Theophanis , Logothetis George , Christophoridou Gesthimani
Published: February 2022

The European turtle dove is an important game bird for the hunters in Greece, which is one of a few European countries where its hunting is allowed. The sustainability of the species’ hunting in Europe is discussed during the last several years due to declines in its population, which forced IUCN to classify it as vulnerable. In Greece, its harvest takes place from 20 August and lasts as long as the presence of the species in the country (mid-October). The ARTEMIS project is a Greek statistical database of hunting characteristics, as revealed by questionnaires distributed to hunters. Statistical indicators such as hunting opportunity and hunting harvest are considered in the literature as reliable to show the population trend of a game species. Therefore, in the present research, hunting statistics are used to determine the population trend of the European turtle dove in Greece. State-space modeling was the main procedure used, a method which allows us to deal with errors that exist from hunting bag data or hunting opportunity data assuming that on average the under and overestimations will be equal. The results of the modeling analysis show a stable trend of the variables used, i.e., hunting opportunity, hunting harvest, and juveniles to adult’s ratio. Additionally, the hunting sustainability index showed that the sustainability of the species is improved annually, as a slight positive trend is revealed. This is in favor of the species, if it is considered that the actual percentage of the turtle dove population harvested is lower, since not all doves are encountered by hunters. It is concluded that for the period 2004/05–2019/20, as indicated by the hunting statistics, the population trend of the European turtle dove in Greece was stable and its harvest sustainable.
Functional Changes of Therapeutic Antibodies upon Exposure to Pro-Oxidative Agents
Authors: Lecerf Maxime , Lacombe Robin , Kanyavuz Alexia , Dimitrov Jordan D.
Published: February 2022

Therapeutic monoclonal antibodies have exerted a transformative impact on clinical practice in last two decades. However, development of a therapeutic antibody remains a complex process. Various physiochemical and functional liabilities can compromise the production or the therapeutic efficacy of antibodies. One of these liabilities is the susceptibility to oxidation. In the present study, we portrayed an oxidation-dependent vulnerability of immunoglobulins that can be of concern for therapeutic antibodies. By using a library of 119 monoclonal IgG1 molecules, containing variable domain matching clinical-stage antibodies, we demonstrated that a substantial number of these molecules acquired antigen-binding polyreactivity upon exposure to ferrous ions. Statistical analyses revealed that the potential for induction of polyreactivity by the redox-active metal ions correlated with a higher number of somatic mutations in V genes encoding variable domains of heavy and light immunoglobulin chains. Moreover, the sensitive antibodies used with biased frequencies particular V gene families encoding variable domains of their light chains. Besides the exposure to ferrous ions the induction of polyreactivity of therapeutic antibodies occurred after contact with an unrelated pro-oxidative substance—hypochlorite ions. Our data also revealed that induction of polyreactivity by pro-oxidative agents did not impact the binding of antibodies to their cognate antigens. The results from this study may contribute for better selection of antibody therapeutics with suitable developability profiles.