bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of risk factors for in-hospital death of COVID - 19 pneumonia -- lessions from the early outbreak
Authors: Wang Zhigang , Wang Zhiqiang
Published: December 2020

Objective: To examine the clinical characteristics and identify independent risk factors for in-hospital mortality of 2019 novel coronavirus (COVID-19) pneumonia.Methods: A total of 156 patients diagnosed with COVID-19 pneumonia at the Central Hospital of Wuhan from January 29, 2020, to March 20, 2020, and 20 healthy individuals were enrolled in this single-centered retrospective study. The epidemiological parameters, clinical presentations, underlying diseases, laboratory test results, and disease outcomes were collected and analyzed.Results: The median age of all enrolled patients was 66 years. At least one underlying disease was identified in 101 COVID-19 patients, with hypertension being the most common one, followed by cardiovascular disease and diabetes. The most common symptoms identified upon admission were fever, cough, dyspnea, and fatigue. Compared to survival cases, patients who died during hospitalization had higher plasma levels of D-dimer, creatinine, creatine kinase, lactate dehydrogenase, lactate, and lower percentage of lymphocytes (LYM [%]), platelet count and albumin levels. Most enrolled patients received antibiotics and anti-viral treatment. In addition, 60 patients received corticosteroids, and 51 received intravenous immunoglobulin infusion. 44 patients received noninvasive ventilation and 19 received invasive ventilation. Respiratory failure was the most frequently observed complication (106 [67.9%]), followed by sepsis (103 [66.0%]), acute respiratory distress syndrome (ARDS) (67 [42.9%]), and septic shock (50 [32.1%]).Multivariable regression suggested that advanced age (OR [odds ratio]=1.098, 95% CI [confidence interval]: 1.006-1.199, P=0.037), shorter duration from onset to admission (OR= 0.853, 95% CI: 0.750-0.969, P=0.015) and elevated lactate level upon admission (OR= 2.689, 95% CI: 1.044-6.926, P=0.040) were independent risk factors for in-hospital mortality for COVID-19 infection. Meanwhile, increased LYM (%) at admission (OR= 0.787, 95% CI: 0.686-0.903, P=0.001) indicated a better prognosis.Conclusions: In this study, we discovered that age, duration from onset to admission, LYM (%), and lactate level upon admission were independent factors that affecting the in-hospital mortality rate.
Genome-wide epigenomic stress response in the European sea bass (Dicentrarchus labrax, L.)
Authors: KRICK Madoka V. , DESMARAIS Erick , SAMARAS Athanasios , GUERET Elise , DIMITROGLOU Arkadios , PAVLIDIS Michalis , TSIGENOPOULOS Costas S , GUINAND Bruno
Published: December 2020

Background: While the stress response inspired genome-wide epigenetic studies in vertebrate models, it remains mostly ignored in fish. We modified the epiGBS (epiGenotyping By sequencing) technique to explore changes in genome-wide cytosine methylation to a repeated acute stress challenge in the nucleated red blood cells (RBCs) of the European sea bass (Dicentrarchus labrax). This species is widely studied in both the natural and farmed environments, including issues regarding health and welfare.Results: We retrieved 501,108,033 sequencing reads after trimming, with a mean mapping efficiency of 73.0% (unique best hits). Minor changes in RBC methylome appear to manifest after the stress challenge. Only, fifty-seven differentially methylated cytosines (DMCs) close to 51 distinct stress-related genes distributed on 17 of 24 linkage groups (LGs) were detected between RBCs of pre- and post-stress individuals. However, literature surveys indicated that 38 of these genes were previously reported as differentially expressed in the brain of zebrafish, most of them involved in stress coping differences. DMC-related genes associated to the Brain Derived Neurotrophic Factor, a protein that favors stress adaptation and fear memory, appear especially relevant to integrate a centrally produced stress response.Conclusion: By putting forward DMCs associated to stress-related genes, we show that minimally invasive RBCs deserve more attention to investigate the epigenetic response to stress and components of the stress response without sacrificing fish. In parallel to blood parameter measurements (e.g. cortisol, glucose levels), and other molecular approaches (e.g. gene expression variation), features of the epigenetic landscape may offer new opportunities for biomonitoring components of the stress response in fish.
Establishment of a Nomogram for Predicting the Surgical Difficulty of Anterior Cervical Spine Surgery
Authors: Ji Chengyue , Rong Yuluo , Wang Jiaxing , Yin Guoyong , Fan Jin , Tang Pengyu , Jiang Dongdong , Liu Wei , Ge Xuhui , Yu Shunzhi , Cai Weihua
Published: December 2020

Background. For a long time, surgical difficulty is mainly evaluated based on subjective perception rather than objective indexes. Moreover, the lack of systematic research regarding the evaluation of surgical difficulty potentially has a negative effect in this field. This study was aimed to evaluate the risk factors for the surgical difficulty of anterior cervical spine surgery (ACSS).Methods. This was a retrospective cohort study totaling 291 consecutive patients underwent ACSS from 2012.3 to 2017.8. The surgical difficulty of ACSS was defined by operation time longer than 120 min or intraoperative blood loss equal to or greater than 200ml. Evaluation of risk factors was performed by analyzing the patient’s medical records and radiological parameters such as age, sex, BMI, number of operation levels, high signal intensity of spinal cord on T2-weighted images, ossified posterior longitudinal ligament (OPLL), sagittal and coronal cervical circumference, cervical length, spinal canal occupational ratio, coagulation function index and platelet count.Results. Significant differences were reported between low-difficulty and high-difficulty ACSS groups in terms of age (p=0.017), sex (p=0.006), number of operation levels (p<0.001), high signal intensity (p<0.001), OPLL (p<0.001) and spinal canal occupational ratio (p<0.001). Multivariate logistic regression analysis revealed that number of operation levels (OR=5.224, 95%CI=2.125-12.843, p<0.001), high signal intensity of spinal cord (OR=4.994, 95%CI=1.636-15.245, p=0.005), OPLL (OR=6.358, 95%CI=1.932-20.931, p=0.002) and the spinal canal occupational ratio>0.45 (OR=3.988, 95%CI=1.343-11.840, p=0.013) were independently associated with surgical difficulty in ACSS. A nomogram was established and ROC curve gave a 0.906 C-index. There was a good calibration curve for difficulty estimation.Conclusion. This study indicated that the operational level, OPLL, high signal intensity of spinal cord, and spinal canal occupational ratio were independently associated with surgical difficulty and a predictive nomogram can be established using the identified risk factors. Optimal performance was achieved for predicting surgical difficulty of ACSS based on preoperative factors.
Critically ill patients with diabetes and Middle East respiratory syndrome: A multi-center observational study
Authors: Jose Jesna , Al-Dorzi Hasan , Al-Omari Awad , Mandourah Yasser , Al-Hameed Fahad , Sadat Musharaf , Al-Qasim Eman , Alraddadi Basem , Harthy Abdulrahman Al , Mekhlafi Ghaleb A Al , Almotairi Abdullah , Khatib Kasim Al , Abdulmomen Ahmed , Qushmaq Ismael , Sindi Anees , Mady Ahmed , Solaiman Othman , Al-Raddadi Rajaa , Maghrabi Khaled , Rajab Ahmed , Kharaba Ayman , Shalhoub Sara , Al-Aithan Abdulsalam M , Vishwakarma Gajendra K , Bhattacharjee Atanu , Arabi Yaseen
Published: December 2020

Background: Diabetes is a risk factor for infection with coronaviruses. This study describes the demographic, clinical data, and outcomes of critically ill patients with diabetes and Middle East Respiratory Syndrome (MERS).Methods: This retrospective cohort study was conducted at 14 hospitals in Saudi Arabia (September 2012- January 2018). We compared the demographic characteristics, underlying medical conditions, presenting symptoms and signs, management and clinical course, and outcomes of critically ill patients with MERS who had diabetes compared to those with no diabetes. Multivariable logistic regression analysis was performed to determine if diabetes was an independent predictor of 90-day mortality.Results: Of the 350 critically ill patients with MERS, 171 (48.9%) had diabetes. Patients with diabetes were more likely to be older, and have comorbid conditions, compared to patients with no diabetes. They were more likely to present with respiratory failure requiring intubation, vasopressors, and corticosteroids. The median time to clearance of MERS-CoV RNA was similar (23 days (Q1, Q3: 17, 36) in patients with diabetes and 21.0 days (Q1, Q3: 10, 33) in patients with no diabetes). Mortality at 90 days was higher in patients with diabetes (78.9% versus 54.7%, p<0.0001). Multivariable regression analysis showed that diabetes was an independent risk factor for 90-day mortality (odds ratio, 2.09; 95% confidence interval, 1.18-3.72).Conclusions: Half of the critically ill patients with MERS have diabetes; which is associated with more severe disease. Diabetes is an independent predictor of mortality among critically patients with MERS.
Integrated metabolic profiling and transcriptome analysis of pigment accumulation in Lonicera japonica flower petals during colour-transition
Authors: Xia Yan , Chen Weiwei , Xiang Weibo , Wang Dan , Xue Baogui , Liu Xinya , Xing Lehua , Wu Di , Wang Shuming , Guo Qigao , Liang Guolu
Published: December 2020

Background: Plants have remarkable diversity in petal colour through the biosynthesis and accumulation of various pigments. To better understand the mechanisms regulating petal pigmentation in Lonicera japonica, we used multiple approaches to investigate the changes in carotenoids, anthocyanins, endogenous hormones and gene expression dynamics during petal colour transitions, i.e., green bud petals (GB_Pe), white flower petals (WF_Pe) and yellow flower petals (YF_Pe). Results: Metabolome analysis showed that YF_Pe contained a much higher content of carotenoids than GB_Pe and WF_Pe, with α-carotene, zeaxanthin, violaxanthin and γ-carotene identified as the major carotenoid compounds in YF_Pe. Comparative transcriptome analysis revealed that the key differentially expressed genes (DEGs) involved in carotenoid biosynthesis, such as phytoene synthase, phytoene desaturase and ζ-carotene desaturase, were significantly upregulated in YF_Pe. The results indicated that upregulated carotenoid concentrations and carotenoid biosynthesis-related genes predominantly promote colour transition. Meanwhile, two anthocyanins (pelargonidin and cyanidin) were significantly increased in YF_Pe, and the expression level of an anthocyanidin synthase gene was significantly upregulated, suggesting that anthocyanins may contribute to vivid yellow colour in YF_Pe. Furthermore, analyses of changes in indoleacetic acid, zeatin riboside, gibberellin (GA), brassinosteroid (BR), methyl jasmonate and abscisic acid (ABA) levels indicated that colour transitions are regulated by endogenous hormones. The DEGs involved in the auxin, cytokinin, GA, BR, jasmonic acid and ABA signalling pathways were enriched and associated with petal colour transitions.Conclusion: Our results provide global insight into the pigment accumulation and the regulatory mechanisms underlying petal colour transitions during the flower development process in L. japonica.
Do they really wash their hands? Prevalence estimates for personal hygiene behaviour during the COVID-19 pandemic based on indirect questions
Authors: Mieth Laura , Mayer Maike , Hoffmann Adrian , Buchner Axel , Bell Raoul
Published: December 2020

Background: During the COVID-19 pandemic, billions of people have to change their behaviours to slow down the spreading of the virus. Protective measures include self-isolation, social (physical) distancing and compliance with personal hygiene rules, particularly regular and thorough hand washing. Prevalence estimates for the compliance with the COVID-19 measures are often based on direct self-reports. However, during a health crisis there is strong public pressure to comply with health and safety regulations so that people’s responding in direct self-reports may be seriously compromised by social desirability.Methods: In an online survey, an indirect questioning technique was used to test whether the prevalence of hygiene practices may be lower than in conventional surveys when confidentiality of responding is guaranteed. The Extended Crosswise Model is an indirect questioning technique that guarantees the confidentiality of responding. To the degree that direct self-reports are biased by social desirability, prevalence estimates of hygiene practices such as thorough hand washing based on the Extended Crosswise Model should be lower than those based on direct self-reports.Results: We analysed data of 1,434 participants. In the direct questioning group 94.5 % of the participants claimed to practice proper hand hygiene; in the indirect questioning group a significantly lower estimate of only 78.1 % was observed.Conclusions: These results indicate that estimates of the degree of commitment to measures designed to counter the spread of the disease may be significantly inflated by social desirability in direct self-reports. Indirect questioning techniques with higher levels of confidentiality seem helpful in obtaining more realistic estimates of the degree to which people follow the recommended personal hygiene measures. More realistic estimates of compliance can help to inform and to adjust public information campaigns on COVID-19 hygiene recommendations.
Effects of Polycyclic Aromatic Hydrocarbon Pendant-Armed Ligands on the Catecholase Activity of Dinuclear Copper(II) Complexes
Authors: da Silva Marcos , Heying Renata , da Silva Letícia , Bortoluzzi Adailton , Peralta Rosely , Neves Ademir
Published: December 2020

Herein, we present three new binuclear copper(II) complexes containing different polycyclic aromatic hydrocarbons, able to catalyze the oxidation of 3,5-di-tert-butylcathecol, a model substrate for catechol oxidase. The ligands and complexes were successful characterized in solid and solution states. The structure of C1 was determined by X-ray crystallography and it contains a [CuII2(L1-μ-phenoxo)(OAc)(H2O)2] unit, with two coppers in a pyramidal square geometry and a large distance of 3.715 Å between the copper(II) centers. All complexes (C1, C2 and C3) were found to be effective catalysts in the oxidation of 3,5-di-tert-butylcathecol to its quinone and C1 provided the highest catalytic constants at the three pH values studied. In addition to their potential use as a biomimetic catalyst in catechol oxidation, the interaction of these complexes with deoxyribonucleic acid from calf thymus (CT-DNA) was also studied, and C3 showed the greatest affinity with nucleic acids.
Avaliação geoquímica da influência de fossas rudimentares na água subterrânea da região rural de Paulínia/SP
Authors: Teramoto Elias , Stradioto Marcia , Chiang Hung
Published: December 2020

Nas áreas rurais do Brasil 75% da população não tem acesso ao sistema de coleta de esgoto. Nestes locais, o efluente doméstico é despejado em fossas sem impermeabilização, o que permite a infiltração e percolação da porção líquida do efluente no solo e contaminar a água subterrânea. Por esta razão, as fossas negras são uma das principais fontes de contaminação por nitrato de aquíferos rasos. Além desta contaminação, pressupõe-se que as características hidroquímicas de aquíferos rasos em áreas rurais são influenciadas pelo influxo de efluente. Para testar esta premissa, foram coletadas e analisadas amostras de água subterrâneas de nascentes e poços rasos na porção norte do munícipio de Paulínia/SP. Constatou-se que a águas subterrâneas sem ação antrópica à montante possuem reduzida concentração de sólidos totais dissolvidos abaixo de 16 mg/L, sugerindo reduzida influência antrópica. Nascentes situadas à jusante de indústrias apresentaram algum tipo de influência antrópica. As nascentes situadas à jusante de residências rurais e poços rasos próximos destas residências apresentaram características que indicam a influência das fossas sépticas, caracterizadas por concentrações de STD, NO3-, Cl-, SO42- e Na+. Embora representem fontes pontuais, as simulações numéricas de fluxo e transporte demonstram que fossas podem gerar plumas de NO3-, Cl- e Na+ com grandes dimensões. O conjunto de resultados obtidos sugere que a influência do ingresso de efluentes domésticos se manifesta pelos incrementos de STD, NO3-, Cl-, SO42- e Na+. Deste modo, conclui-se que as fossas são importantes agentes atuantes na composição química de aquíferos rasos em áreas rurais.
Recent advances in the development of chemotherapeutic agents for malaria.
Authors: Shrivastava Neelima , Khan Shah A. , Ahmad Saif , Al Balushi Khalid , Husain Asif
Published: December 2020

Introduction:

Malaria, a devastating infectious parasitic disease, has been recognized by the World Health
organization (WHO) as a major public health problem worldwide. It is one of the leading causes of morbidity and mortality
in the developing countries. There are fewer number of the antimalarial drugs available in the market to combat this deadly
disease. The situation is further worsened due to the emergence of resistant strains of Plasmodium falciparum, which
warrants the search for novel antimalarial drugs capable of acting at multiple targets to expand the current antimalarial
drug arsenal for better therapeutic outcome.

Objectives:

This review aimed to provide the reader with the recent advances and progress made in the development of
chemotherapeutic agents for malaria.

Methods:

Literature review data on chemistry and antimalarial activity of natural and synthetic heterocyclic compounds
published in the last ten years were compiled by referring various peer reviewed journal websites and medical search
engines.

Results and discussion:

This review is covers the recent advances and progress made in the treatment strategies, patent
granted, synthetic approaches, mechanism of action with more emphasis on structure activity relationship (SAR) of potential
chemotherapeutic agents as antimalarial agents which could pave the way for the development of more effective and potent
antimalarial agents. This review might interest the fellow researchers working on the development of novel antimalarial
drug candidates with better therapeutic index.

Conclusion:

Based on the literature covered in the current review article and seeing the recent trends, authors are of the
opinion that the multi target conjugated hybrid approach is the best strategy to discover and develop the effective
antimalarial agents.
ADAPTIVE POSSIBILITY OF THE ORGANISM OF WOMEN WITH PHYSIOLOGICAL PREGNANCY AND EXTRACORPORAL FERTILIZATION
Authors:   Tyumen State Medical University, Chehova J.S. , Kashuba E.A. ,   Tyumen State Medical University, Solov'eva S.V. ,   Tyumen State Medical University, Antonova M.V. ,   Tyumen State Medical University
Published: December 2020

The study of the restructuring of the body of a pregnant woman with relation to the theory of functional systems is necessary for a complete understanding of the formation of adaptive processes. Of particular interest is pregnancy resulting from extracorporeal fertilization (IVF). Aim. to estimate the adaptive capacity of women with physiological pregnancy and IVF. Materials and methods. The object of the study: healthy women before pregnancy and in the I trimester (I group), patients with tubal-peritoneal infertility at the planning stage and after an effective IVF (II group), women with an unsuccessful IVF (III group). We conducted a study of the functional state of the cardiovascular system of pregnant women with the calculation of adaptive potential (AP) by R. M. Bayevsky. We assessed the regulation of the vegetative nervous system — Kerdo index (KI). We determined the state of regulatory systems with the stress index (L.H. Garkavi et al.). Results. In patients with physiological pregnancy, we noted the effect on the cardiovascular system of the autonomic nervous system and the tension of adaptive reactions. In pregnant women with IVF we recorded the depletion of adaptive activity of the sympathetic autonomic nervous system. This led to a significant strain or failure of adaptation with the predominant influence of the parasympathetic autonomic nervous system. Conclusion. Significant differences in the studied parameters in women with ineffective IVF program at the stage of pregnancy planning may have important prognostic value for determining the tactics of management of patients.
THE SYNDROME OF NEUROLOGICAL DISORDERS AS A PREDICTOR OF EARLY DIAGNOSIS AND A CRITERION FOR THE EFFECTIVENESS OF SURGICAL TREATMENT OF NONSPECIFIC PURULENT DISEASES OF THE SPINE
Authors:   Sverdlovsk Regional Clinical Hospital No. 1, Goncharov M.Yu. , Masyutina D.D. ,   Ural State Medical University
Published: December 2020

Nonspecific purulent diseases of the spine (NPDS) are a relatively rare pathology that is little known to a wide circle of doctors, as a result of which mistakes are often made in the tactics of patient management, the timing of diagnosis and the appointment of adequate therapy is delayed. Long-term «diagnostic trap» leads to the formation of persistent neurological deficits. Goal. The purpose is to study the structure of neurological manifestations in the diagnosis NPDS and the dynamics in assessing the quality of surgical treatment. Materials and methods. The article presents an analysis of a group of patients receiving treatment for NPDS in the neurosurgical department of State budgetary health institution in the Sverdlovsk region '‘Sverdlovsk Regional Clinical Hospital No. 1’' in Yekaterinburg for the period from 2005 to 2018 with an assessment of the dynamics of neurological disorders and vertebral pain syndrome in the early postoperative period. A significantly better result in assessing regression of neurological disorders and a decrease in the severity of pain in the postoperative period was observed in the group of patients who underwent decompression-sanitizing-stabilizing surgeries (DSS) in comparison with decompression-sanitizing (DS). Conclusions. The understanding by primary care physicians, neurologists, neurosurgeons of high-risk patient groups, the dynamics of clinical manifestations, and effective diagnostic methods contributes to the choice of the correct management tactics and timely surgical treatment, which significantly improves outcomes, reduces disability rates, and improves the quality of life of patients.
Kesuksesan Karier Subjektif sebagai Identitas Karier Karyawan
Authors: Ingarianti Tri Muji , Fajrianthi Fajrianthi , Chusairi Achmad
Published: December 2020

Kesuksesan karier subjektif dipandang sebagai bidang utama yang diminati dan eksplorasi, baik di bidang akademik maupun praktik. Konteks karier modern lebih menekankan pada mobilitas dan ketidakpastian. Oleh karena itu, karyawan tidak lagi hanya mengandalkan organisasi untuk mencapai kesuksesan kariernya. Mereka memiliki tanggung jawab untuk mengelola dan menciptakan pilihan-pilihan karier mereka sendiri. Memahami kesuksesan karier subjektif adalah tugas penting bagi individu dan organisasi. Tujuan dari tulisan ini adalah untuk melakukan telaah literatur yang relevan mengenai kesuksesan karier subjektif dan mengembangkan kerangka teoretis tentang konsep dan definisi kesuksesan karier subjektif, faktor-faktor yang berhubungan dengan kesuksesan karier subjektif, dampak dari kesuksesan karier subjektif dan peran identitas karier terhadap kesuksesan karier subjektif.
El dilema de Margot: la salida es por la puerta trasera
Authors: Tovar Torres Tania
Published: December 2020

¿Qué pasa cuando un edificio deja de existir? ¿Qué pasa cuando la realidad sobre un edificio o una obra de arte se convierte en objeto de reconstrucción? Este ensayo argumenta la posibilidad de que la arquitectura ya no sobreviva como objeto –edificio– sino como documento, como historia. Contado a través de un dilema desenterrado por una carta de Margot Wellington a Gordon Matta-Clark, se presenta la relación entre el archivo, la arquitectura y las artes. En este sentido, se pone en duda la temporalidad de la arquitectura, ya que su historia puede ser reproducida y recreada a través de los documentos y páginas que se encuentran en el archivo, lo cual deja la pregunta abierta de qué fue primero, el edificio o el documento.
An Inquiry into the Impact of Stress on New School Leaders within a Unique Mentorship Experience
Authors: Rommel Jodie , Cooner Donna
Published: December 2020

This study aimed to identify the sources of stress new school leaders encounter that may influence their mental health. This study used semi-structured focus groups to elicit thick, rich descriptions of participants’ experiences. The extensive data sets were collected over two years from 16 focus group interviews conducted during Colorado State University School Leadership Institute retreats. Narrative analysis of participants’ responses provided findings on the stress they experienced, including fear of failure or insecurity, pressure to perform, isolation, work-life balance, time constraints, and compassion fatigue. The participants identified that this unique mentorship opportunity allowed for self-reflection, self-care, and reconnecting with their purpose; furthermore, participants shared that the School Leadership Institute offered support and connectedness in a safe, non-evaluative environment. They shared the importance of strong building-level team support, the cathartic nature of the focus group interviews, and the positive progression from year to year in their roles.
RELAÇÃO ENTRE DOR MUSCULOESQUELÉTICA E CONDIÇÕES DE TRABALHO DE POLICIAIS MILITARES
Authors: Santos Helen Caroline de Morais , Viana Fabiana Cury , Silva Deivid Kennedy da
Published: December 2020

The military policeman's work activity can lead to musculoskeletal overload, due to long working hours, standing for many hours and the use of heavy equipment such as the ballistic vest, which can cause discomfort, fatigue and musculoskeletal pain, predisposing these professionals to pain. That compromise your health and quality of life. This study aimed to evaluate the perception of musculoskeletal pain of military police, identifying the presence of painful points and establishing relationships between the points found and their working conditions. Fifty-five military police officers of both sexes, with more than five years of service to the institution, who belonged to the 15th Battalion of the city of Patos de Minas-MG, participated in the study. The sociodemographic and health questionnaire was applied and, subsequently, the “Body Pain Map”. All police officers had pain in some region of the body after the workday. Associations between the body regions with pain, the use of the ballistic vest, work vehicle and length of service, showed involvement mainly in the lower back region. Given the results presented, there is a prevalence of pain in the lower back followed by pain in the thoracic region. All participants were wearing the ballistic vest, a fact that influenced the presence of the painful points presented. Therefore, studies are important in order to detect health risk factors for these workers, in order to propose strategies that improve their quality of life.
Hyperbaric oxygen therapy in treatment of sudden sensorineural hearing loss: finding for the maximal therapeutic benefit of different applied pressures
Authors:   Faculty of Healthcare, Alexander Dubček University of Trenčín, Trenčín, Slovak Republic, Krajčovičová Zdenka , Meluš Vladimír ,   Faculty of Healthcare, Alexander Dubček University of Trenčín, Trenčín, Slovak Republic, Zigo Rastislav ,   Department of Otolaryngology, Faculty Hospital Trenčín, Trenčín, Slovak Republic, Matišáková Iveta ,   Faculty of Healthcare, Alexander Dubček University of Trenčín, Trenčín, Slovak Republic, Večeřa Ján ,   Department of Otolaryngology, Faculty Hospital Trenčín, Trenčín, Slovak Republic, Králová Eva ,   Faculty of Healthcare, Alexander Dubček University of Trenčín, Trenčín, Slovak Republic
Published: December 2020

We compared the efficacy of hyperbaric oxygen (HBO2) therapy used in the treatment of sudden sensorineural hearing loss (SSNHL) as a supplementary therapy to the first-line medical treatment according to the different applied pressures used in HBO2 treatment while maintaining the same number of sessions, periodicity and exposure times. We evaluated data from 115 patients suffering from SSNHL within seven days of hearing loss: 35 patients received the standard treatment protocol (control group), and 80 individuals were treated with additional application of HBO2 therapy pressured to 2.0 ATA (H2.0; n=49) or 2.5 ATA (H2.5; n=31), respectively. Treatment success was assessed using pre- and post-treatment audiograms. We found significant differences in both HBO2 groups compared to the control group. In low frequencies the most significant differences can be seen in both H2.0 and H2.5. In spoken speech frequencies only the H2.0 group was statistically significant. In high frequencies the therapeutic benefits were the lowest. Furthermore, we found a notable difference in the therapeutic effect of HBO2 therapy according to the different applied pressure. At low frequencies, the use of 2.5 ATA pressure was more efficient. However, in the higher frequency ranges, the better hearing gains were obtained at the 2.0 ATA pressure. Our results support the possibility of optimizing treatments individually, depending on the type and frequency range of hearing impairment (shape of the audiogram) in favor of using the 2.0 ATA. This is important in terms of an individual approach to each patient as well as to minimize the burden of a patient in order to obtain the maximum therapeutic effect.
Hyperbaric treatment for decompression sickness: current recommendations
Authors:   Depts. of Anesthesiology and Medicine, Center for Hyperbaric Medicine & Environmental Physiology, Duke University Medical Center, Durham, North Carolina U.S., Moon Richard E. , Mitchell Simon ,   Department of Anaesthesia and Perioperative Medicine, Auckland City Hospital, Auckland, New Zealand,   Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
Published: December 2020

Rationale Decompression sickness (DCS, “bends”) is caused by formation of bubbles in tissues and/or blood when the sum of dissolved gas pressures exceeds ambient pressure (supersaturation) [1]. This may occur when ambient pressure is reduced during any of the following: • ascent from a dive; • depressurization of a hyperbaric chamber; • rapid ascent to altitude in an unpressurised aircraft or hypobaric chamber; • loss of cabin pressure in an aircraft [2] and • during space walks.
Hyperbaric oxygen therapy for perioperative posterior ischemic optic neuropathy: a case report
Authors:   Department of Emergency Medicine, University of Maryland Medical Center, Baltimore, Maryland, Alhashem Hussain M. , Sward Douglas G. ,   Department of Emergency Medicine, University of Maryland School of Medicine, Baltimore, Maryland, Sethuraman Kinjal ,   Department of Emergency Medicine, University of Maryland School of Medicine, Baltimore, Maryland, Mathews Michaela K. ,   Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, Maryland
Published: December 2020

Purpose: To report the successful treatment of postoperative posterior ischemic optic neuropathy (PION) with hyperbaric oxygen therapy and to review the current literature on the pathogenesis and treatment of PION. Observations: During an angiographic procedure at a community hospital, an elderly woman had a transient drop in blood pressure after receiving an intravenous dose of hydralazine. During recovery, the patient experienced bilateral vision loss. She was transferred to our specialty referral center for treatment with hyperbaric oxygen. We followed Table 5 in the U.S. Navy Diving Manual, the protocol for decompression sickness. Our patient’s vision improved markedly immediately after the first session and continued to improve throughout the course of treatment to its completion. Follow-up ophthalmology visits found the patient’s vision to be close to baseline. Conclusions and importance: PION is a rare condition. It has been difficult to determine a successful therapeutic approach because of the lack of large case-controlled studies. Hyperbaric oxygen has been used to treat other ischemic ophthalmic conditions, but there are only few reports of its use in patients with PION. Systemic steroids and antiplatelet therapy have also been used, with mixed success. In our patient, the combination of hyperbaric oxygen therapy and steroids was successful in restoring vision after postoperative PION.
El parto pretérmino desde los registros del nacido vivo en Colombia, período 2008 – 2017
Authors: Gerónimo Ortega Nestor Ricardo
Published: December 2020

Introducción: El parto pretérmino es uno de los principales problemas de la salud infantil. Es la principal causa de mortalidad infantil en los países en vía de desarrollo. Los últimos 20 años ha venido en aumento en el mundo por diferentes causas. Conocer su tendencia y características poblacionales es un elemento útil para su atención.
Objetivo: Describir las características poblacionales asociados al parto pretérmino en Colombia desde los datos del Registro del Nacido Vivo en la década 2008 – 2017.
Métodos: Estudio descriptivo ecológico a partir de fuentes segundarias: microdatos de Estadísticas Vitales del DANE; información almacenada en el programa Excel de Microsoft Office®. Análisis de las variables tiempo/lugar/persona en el programa estadístico SPSS™ mediante estadística descriptiva, análisis de asociación utilizando el estadístico Ji-cuadrado y el coeficiente de correlación Phi para la asociación estadística entre variables. 
Resultados. Fueron analizados 6.705.385 registros de nacidos vivos, 1.277.839 correspondientes a parto hasta las 37 semanas de gestación. Prevalencia del 19% de todos los años. Departamentos con mayor tasa de prematuros: Atlántico, Bogotá, Antioquía y Santander. No se encontró una asociación fuerte con los datos del registro del nacido vivo.
Conclusiones: Existe déficit de información acerca del parto pretérmino en aspectos de datos completos y accesibles a los investigadores. La información no es homogénea ni sigue parámetros específicos. El registro de nacido vivo, sin embargo, es un excelente instrumento de recolección de datos poblacionales y base de aproximación al evento.
ABCC2(rs717620), and ABCC3 (rs4793665) affect high dose Methotrexate toxicity, and outcome in children with osteosarcoma
Authors: Yahia Amr , Labib Rania , Abdelshafi3 Sameh A. , Salama Asmaa , Hassanain Omneya , Rabea Hoda , Elnadi Enas
Published: December 2020

Objectives: Osteosarcoma (OS) is one of the aggressive bone tumors
commonly diagnosed in adolescents and young adults. The study
investigated the effect of 9 single nucleotide polymorphisms (SNPs) in 5
genes on methotrexate (MTX) plasma level and its impact on the patients’
clinical outcomes. Methods: One hundred and thirty-three patients with
OS (68 boys and 65 girls with age range 4.00-17.86 years) were enrolled
and treated with four weeks of high-dose methotrexate (HDMTX) as
neo-adjuvant therapy in children’s cancer hospital (CCHE-57357). Blood
samples were collected and genotyped for the studied SNPs (MTHFR
rs1801133, SLCO1B1 rs11045879, rs4149081, rs2306283, ABCC3 rs4793665,
rs4148412, rs733392 ABCG2 rs2231142, and ABCC2 rs717620 using Taqman®
(RT-PCR) assay. Plasma concentrations of MTX were measured using the
enzyme multiple immunoassay technique (EMIT®). The clinical outcomes
included toxicities that were evaluated based on the common terminology
criteria for adverse events - version 5 (CTCAEv5.0.), besides the
studying of survival analysis and tumor necrosis (TN %). Results: Older
patients experienced increased risk of delayed MTX elimination at
72-hour, OR=1.19 (95% CI=1.09-1.29, p=0.00059). The studied SNPs
weren’t associated with MTX elimination. Patients with ABCC2 HW
(Homozygous wild) genotype group showed a high statistically significant
association with higher grade hyperbilirubinemia, OR= 2.05(95%
CI=1.05-4.01, p=0.037). Moreover, the patients with ABCC3 (rs4793665) HV
and HT (Homozygous variant and Heterozygous) genotypes had a significant
association with severe nephrotoxicity, OR= 0.34(95% CI=1.6-0.72,
p=0.005). Conclusions: ABCC2 (rs717620), ABCC3 (rs4793665) genotyping
with age and gender could help in predicting patients at risk of
toxicities due to HDMTX.
Cultura e experiência, cotidiano e vulnerabilidade
Authors: Barra e Lopes Edmar Aparecido de
Published: December 2020

As categorias de cultura e experiência, cotidiano e vulnerabilidade, em particular, a partir da década de 1970, situam-se no centro da problematização sobre os estudos urbanos. Nesse sentido, configura-se como mediações fundamentais ao aprofundamento da sua renovação teórica e metodológica. O objetivo desse trabalho (construído com base em literatura especializada e interdisciplinar) é o de fazer um esforço de comparação, visando demonstrar como essas categorias tem contribuído para transformar as dinâmicas de dois campos disciplinares, em particular: a Sociologia Urbana (pós década de 1960) e a História Oral. Além de estimular relações de complementariedade entre esses e outras áreas das Ciências Sociais.
EDUCAÇÃO PARA PAZ NO CURSO PRÉ UNVERSITÁRIO POPULAR CULTURA DA PAZ EM RIO GRANDE-RS.
Authors: Senna Jéssica Rocha , Da Silva Peterson Fernando Kepps , Pereira Vilmar Alves
Published: December 2020

Este trabalho apresenta um relato de experiência a partir do projeto intitulado “Cultura da Paz”, no qual busca possibilidades tanto de reflexão acerca da vida quanto do ingresso de sujeitos privados de liberdade ao Ensino Superior. O curso pré-universitário “Cultura da Paz” é um projeto de extensão desenvolvido pela Universidade Federal do Rio Grande (FURG), a partir do Programa de Auxilio ao Ingresso nos Ensinos Técnico e Superior (PAIETS). Os estudantes que integram o curso são, exclusivamente, apenados do regime aberto e semiaberto da Penitenciária Estadual do Rio Grande (PERG). Tendo por referência os conceitos de Educação Para Paz e Justiça Restaurativa objetivamos, apresentar algumas ações desenvolvidas ao longo dos seus dois anos de vigência, e também a fecundidade dessas duas categorias para pensarmos novos paradigmas de justiça social e de direitos humanos. A experiência ocorreu nos extremos sul do Brasil em Rio Grande-RS.
Investigación y extensión funciones académicas fundamentales en la formación ambiental de los docentes
Authors: Hidalgo López Carelia Rayen
Published: December 2020

La educación ambiental (EA), como proceso educativo interdisciplinar, contextualizado, dinámico, dialógico y crítico, desde sus raíces ha buscado la participación activa de los docentes. Para su alcance se requiere de la formación continuada en un accionar pertinente, donde la investigación y extensión resultan funciones académicas esenciales para lograrlo. En tal sentido este ensayo surge de la experiencia de vida de trabajar por más de 25 años en extensión-investigación y EA, y por más de 10 años en programas de formación ambiental docente. Fue motivado por ser invitada como conferencista en la Universidade Federal do Pampa del campus de Jaguarão en el sur de Brasil durante el debate sobre “Formación de profesores, investigación y extensión en educación ambiental”. En términos generales, fundamentado en dicha experiencia, ser docente en la actualidad requiere de un continuo proceso de formación consciente sobre la transversalidad de la dimensión ambiental en la educación. También requiere de la continua curiosidad para conocer y valorar las diversas realidades que lo circunscriben, así como del accionar ambiental con los actores sociales donde se desenvuelve. En esto el amor y pasión como esencia humana del ser docentes se confronta a contextos políticos, sociales, económicos y ecológicos que demandan de la creatividad permanente, el compromiso para superar las dificultades y cambiar las realidades insustentables de un modelo hegemónico homogeneizador.
Docência e Educação de Jovens e Adultos: Um Olhar sob as Lentes de Pesquisadores da UERGS
Authors: Sant' Anna Sita Mara Lopes , Gafforelli Catiana Dias , Stramare Odilon Antônio , Padilha Camila dos Santos
Published: December 2020

Este artigo objetiva apresentar excertos de levantamentos, estudos e pesquisas desenvolvidas através do Grupo de Pesquisa do CNPq, intitulado: Educação de Jovens e Adultos: docência, formação de professores e processos pedagógicos da EJA, que visa mapear a constituição da docência em EJA no Rio Grande do Sul - Brasil. Para tanto, o artigo apresenta um estudo teórico sobre a docência na EJA; levantamento sobre a docência em produções stricto-sensu nas Instituições de Ensino Superior (IES) públicas do Estado; resultado parcial de pesquisa sobre abordagens de EJA no projetos de cursos de licenciaturas da Universidade Estadual do Rio Grande do Sul e a constituição da oferta de EJA/Educação Básica, núcleos e grupos de pesquisa, em 2018. O que nos mobiliza a produção desse levantamento é o questionamento de como a docência na EJA vem sendo abrangida, conceitualmente, nas pesquisas de mestrado, na formação inicial e em abordagens de oferta na Educação Básica.  Do ponto de vista metodológico, parte-se de orientações da pesquisa qualitativa em educação para a execução dos levantamentos. Como resultados, pode-se afirmar que a docência se mostra multirreferenciada, por diferentes nuances e a EJA passa a ser compreendida como campo árido de estudos. Importante salientar, também, que estes estudos apresentados em Jaguarão, já surtem efeitos, tanto no que tange à ampliação de núcleos e grupos de pesquisa nas IES públicas, quanto no que se refere a movimentos de revisão dos currículos das licenciaturas. Este, talvez, seja o mais significativo entre os efeitos observados.
ISSUES OF DESIGN OF INFORMAL LEARNING SPACES IN THE UNIVERSITY CULTURAL CENTERS
Authors:   Lviv Polytechnic National University Department of Architectural Environment Design, O Dmytrash
Published: December 2020

The article presents an overview and analysis of the state of research in the field of design and exploitation of modern educational spaces in universities around the world, namely areas with flexible planning, called informal learning space. According to the research conducted, the general characteristic and classification were developed and the basic principles of designing this space were revealed. The study identified several problems that arise during its exploitation, which should be taken into account in the designing process. There is described the experience of educational design of interuniversity cultural centres with the application of the developed theoretical bases of designing of informal educational space.
THE ARCHITECTURE OF WOODEN TEMPLE BUILDINGS - MODERNITY AND THE FORM OF IDENTITY
Authors:   Lviv Polytechnic National University, Department of Architecture and Conservation, R Hnidets , M Yasinskyi ,   Lviv Polytechnic National University, Department of Architecture and Conservation
Published: December 2020

Understanding the tradition, innovation and national identity of examples of wooden temple buildings, in particular, Ukrainian churches, certain trends are identified, which in their essence become the main ones, regarding the intensity of development in temple construction. The factors of tradition and innovation are identified as important mediums for establishing the national identity of the image of wooden temple buildings, and their expression in the modern temple-building process of creating a Christian shrine.
VISUAL AND AESTHETIC EVALUATION OF THE TRACE HIGHWAYS IN THE LANDSCAPE
Authors:   Lviv Politechnic National University, Department of Urban Planning, B. Posatskyi , T. Mazur ,   Lviv Politechnic National University, Department of Urban Planning, E. Korol ,   Lviv Politechnic National University, Department of Urban Planning
Published: December 2020

The article substantiates the relevance and considered methodological approaches to the architectural and landscape organization of road space as a set of measures aimed at improving its visual and aesthetic characteristics
NATURE AND FORTIFICATION STRUCTURES OF DOWNTOWNS IN THE CITIES OF KYIV REGION IN THE 17th – END OF THE 18th CENTURIES
Authors:   Lviv Politechnic National University, Department of Architecture and Conservation, O. Rybchynsky
Published: December 2020

This article describes the nature and fortification structure of downtowns in the cities of Kyiv region in the 17th - late 18th centuries. Geometric and proportional properties of strengthening downtowns are determined. Stages of formation and features of changes in the fortifications of the downtown and castles during the 17th-18th centuries in the cities of Kyiv region are revealed.
SOCIAL SCENARIO AND FORMATION OF THE CONCEPT OF A MULTI-APARTMENT RESIDENTIAL COMPLEX
Authors:   Kyiv National University of Construction and Architecture, Department of Information Technologies in Architecture, H. Yablonska
Published: December 2020

The article describes the features of the scenario approach for creating the concept of multi-apartment urban housing, in particular, residential complexes; shows the expediency of its application for such tasks; defines the social scenario of a residential complex; gives examples of possible socio-demographic scenarios that can form the basis of a general urban planning, spatial and planning concept and be a motivated basis for drawing up a task for designing multi-apartment residential complexes.
FORMING PRINCIPLES OF SPATIAL-PLANNING MODEL FOR RECREATION ENVIRONMENT IN RURAL LOCAL CONDITIONS
Authors:   Kyiv National University of Construction and Architecture, Department of Landscape Architecture, L. Chyzhevska
Published: December 2020

The article discusses the basic principles of the formation of a spatial planning model of the recreational environment in rural areas. It is illustrated by examples of design practice.
REAKSI PASAR MODAL INDONESIA TERHADAP PELUNCURAN RUDAL KOREA UTARA
Authors: Dwianto Nicholas Arditya , Yulita Ima Kristina
Published: December 2020

This study aimed to examine the Indonesia capital market reaction to the North Korean missile launching. The type of this research is an event study by using the market model estimation to estimate the expected return. This research used 100 days as the estimated period and 9 days as the windows period. The sample of this research consisted of 76 companies listed in the Index Kompas 100. The result shew that the stock price did not react negatively toward North Korean missile launching. In this research, the emergence of disturbing events at t+3 and t+4 that North Korea succeded in testing hydrogen bomb disturb the events observed by the author. At t +3 and t+4, the stock price react negatively and significantly. The result of this research supported the Signaling theory that the information about a country’s particular events such as information about North Korea’s succes in testing a hydrogen bomb was interpreted as a negative signal (bad news)