bluuebunny/crossref_metadata_2025 huggingface dataset:
Transitude : pratiques et effets des réassignations post-mortem
Authors: Espineira Karine
Published: July 2020

En raison d’un sentiment d’illégitimité à vivre, de difficultés à braver les normes et de l’effritement du capital de résilience face aux rejets et discriminations, des personnes trans de tous âges et de tous milieux renoncent à la vie en se suicidant. D’autres sont assassinées et viennent allonger la liste des victimes de transphobie. Ces personnes font l’objet de réassignations post-mortem, dont on trouve des traces depuis leivesiècle. Le sujet demande d’être abordé avec précaution car ces expériences de vie sont liées au genre et plus précisément au franchissement de genre, pour des personnes qui correspondent peut-être aux cas de figure que l’on comprend auxxesiècle sous le terme transgenre. Dans cet article, nous nous proposons d’interroger des franchissements de genre à travers les âges en mesurant les effets des réassignations post-mortem, voire des effacements, à l’aide d’exemples. Les réassignations et leurs conséquences seront aussi décrites et analysées à partir de contenus identifiés dans les médias contemporains, particulièrement quand la mort de personnes trans est traitée dans le registre du fait divers et quand le genre devient un outil de mise en scène. La proposition d’ouverture à l’intersectionnalité a pour objectif de montrer que le traitement médiatique et les réassignations post-mortem révèlent la persistance des inégalités parfois même sous de nouvelles formes.
« Fix society. Please. » Suicidalité trans et modèles d’interprétation du suicide : repenser le suicide à partir des voix des personnes suicidaires1
Authors: Baril Alexandre
Published: July 2020

Alors que les modèles médical et biopsychosocial du suicide ont fait l’objet de critiques, le modèle social adopté dans les études/mouvements trans n’est pas remis en question à partir de perspectives anti-oppressions. Ainsi, les limites de ce modèle sont sous-théorisées. La question au coeur de cet essai est : quelles sont les limites du modèle social sous-tendant les analyses de la suicidalité trans? Basé sur une analyse critique des discours des travaux des autrices et auteurs qui ont adopté le modèle social, le présent article démontre que les discours sur la suicidalité trans au sein des études/mouvements trans reproduisent des formes de stigmatisation, de marginalisation et de pathologisation des personnes (trans) suicidaires. Je défends la thèse selon laquelle le modèle social produit une violence épistémique qui relève du capacitisme mental (ou sanisme) et du suicidisme (oppression des personnes suicidaires) en délégitimant les voix des personnes suicidaires.
Correlation Between Disclosure Status and Stress in Men Who Have Sex with Men with HIV
Authors: Edianto Edianto , Waluyo Agung , Yona Sri , Martiana Ina
Published: July 2020

Men who have sex with men living with HIV (MSM-LWH) experience psychological and social issues, including depression, anxiety, fear of infecting others, frustration, and social isolation. They may also experience problems in their relationships due to a fear of social stigma, such as marital issues, family conflicts, a lack of family support, economic difficulties, and social rejection by the family. This research aimed to assess the relationship between HIV status disclosure and stress in MSM-LWH in Medan, Indonesia. Here, a cross-sectional design and the convenience sampling technique were used. A total of 176 respondents who were MSM, HIV positive, and residents of Medan City were included in this work. Data were collected by means of HIV Status Disclosure questionnaires and a Perceived Stress Scale (PSS). Overall, 70.9% respondents reported disclosing their status to others and approximately half revealed experiencing stress. Moreover, HIV status disclosure was significantly associated with stress (p= 0.025). This study reveals that HIV status disclosure may result in negative effects on MSMLWH, represent a barrier to medical treatment, and increase internal stress. Abstrak Hubungan antara Status Disclosure dengan Stres pada Lelaki yang Berhubungan Seks dengan Lelaki dengan HIV. Lelaki yang berhubungan Seks dengan lelaki (LSL) yang hidup dengan HIV mengalami maslah psikologis dan social termasuk depresi, kecemasan, ketakutan menulari orang lain, frustasi dan isolasi sosial. Selain itu juga mengalami masalah dalam hubungan sosial karena takut akan stigma, konflik dalam keluarga, kurangnya dukungan keluarga, kesulitan ekonomi dan penolakan oleh keluarga. Penelitian ini bertujuan untuk mengetahui hubungan antara status disclosure HIV dengan stress pada LSL yang hidup dengan HIV di Medan, Indonesia. Metode yang digunakan adalah cross-sectional dengan menggunakan teknik convenience sampling. Sebanyak 176 responden LSL dengan HIV positif dan tinggal di wilayah kota Medan. Data dikumpulkan dengan menggunakan HIV Status Disclosure Questionare dan Perceived Stress Scale (PSS). Hasil penelitian menemukan bahwa sebanyak 70,9% responden memiliki status disclosure HIV rendah, sementara itu sebanyak 55,1% resonden mengalami stress yang tinggi. Status disclosure HIV secara bermakna dikaitkan dengan stress (p= 0,025; α= 0,05). Dapat disimpulkan bahwa status disclosure HIV dapat memberikan efek negatif pada LSL yang hidup dengan HIV dan menjadi penghalang untuk perawatan medis dan meningkatkan stress internal. Kata Kunci: HIV, status disclosure, lelaki yeng berhubungan seks dengan lelaki, stres
Do Plantar Pressure and Loading Patterns Vary with Joint Hypermobility in Young Females?
Authors: Torgutalp Şerife Şeyma , Babayeva Naila , Özkan Ömer , Yilmaz Seval , Dönmez Gürhan , Korkusuz Feza
Published: July 2020

Background

Joint hypermobility is a connective tissue disorder that increases joint range of motion. Plantar pressure and foot loading patterns may change with joint hypermobility. We aimed to analyze static plantar pressure in young females with and without joint hypermobility.

Methods

Joint laxity in 27 young females was assessed cross sectionally using the Beighton and Horan Joint Mobility Index. Participants were divided into the hypermobility (score, 4–9) and no hypermobility (score, 0–3) groups according to their scores. Static plantar pressure and forces were recorded using a pedobarographic mat system.

Results

Higher peak pressures (P = .01) and peak pressure gradients (P = .025) were observed in the nondominant foot in the hypermobility group. According to the comparison of dominant and nondominant feet in each group, the hypermobility group showed significantly higher peak pressures (P = .046), peak pressure gradients (P = .041), and total force values (P = .028) in the nondominant foot.

Conclusions

The plantar pressure and loading patterns vary in young females with joint hypermobility. Evaluation of plantar loading as an injury prevention tool in individuals with joint hypermobility syndrome can be suggested.
Machine Learning Based Anomaly Detection as an Emerging Trend in Telecommunications
Authors: Đorđević Valentina , Miloševic Pavle , Poledica Ana
Published: July 2020

Research Question: This paper investigates into how machine learning can be applied for the purpose of detecting anomalies in the data describing transport component within the cellular network. Motivation: In the field of telecommunications, terabytes of data are generated each hour. This makes the manual analysis almost impossible to perform. There are thousands of components whose behaviour needs to be monitored, since anomalous behaviour could indicate a possible failure that can lead to network degradation, huge maintenance costs, and finally – a bad user experience. Our goal is to try to catch anomalous behaviour automatically, and thus help domain experts when performing drill down analysis of the degraded base stations and their key performance indicators (KPIs). Idea: The main idea of this paper is to empirically evaluate the application of machine learning for the problem of anomaly detection, in the field of telecommunications, specifically to long term evolution (LTE) networks. Data: Data used in the analysis contains information about base transceiver stations (BTS) behaviour through the time. The data are gathered from a cellular network provider located in Serbia. The data are collected on an hourly basis, for a period of two weeks, resulting in almost 700 thousand rows. The behaviour is assessed by 96 transport KPIs coming from BTS, describing the package losses, delays, transmission success rates, etc. Tools: Two main algorithms, ensemble-based Isolation Forest and autoencoder neural network, are elaborated and applied in order to identify patterns of anomalous behaviour. Findings: The results show that machine learning can be successfully applied in the field of LTE networks for the problem of anomaly detection. Machine learning can significantly reduce the time needed for the domain experts to identify anomalies within the network. In addition to time efficiency, one of the algorithms tested is able to identify anomalous KPIs separately, which is crucial when performing root cause analysis, by using drill-down approach, in order to identify which component is degraded. Contribution: This paper enriches existing research related to anomaly detection in LTE networks and provides an innovative approach to automated root-cause analysis of network degradation.
Moderator Effects of the Employees’ Gender on the Correlation between Facets of Job Satisfaction and Personality Dimensions
Authors: Nedeljković Knežević Milena , Nedeljković Slađana , Mijatov Maja , Vukonjanski Srdić Jelena
Published: July 2020

Research Question: The research is oriented towards determining the moderator effects of the employees’ gender (structure) on the correlation between other research constructs, i.e., personality dimensions and job satisfaction. Motivation: Previous research on the influence of employees’ personality dimensions and gender as potential predictors of job satisfaction was also conducted in Serbia. However, no studies could be found in the literature focusing on identifying the moderating effect of the employees’ gender on correlation between job satisfaction and personality dimensions. The results would be of practical importance and applicable in human resource management practice in different organizations, particularly in transitional societies. Idea: The main subject of this research is oriented towards the employees’ dimensions of personality, according to the Big Five personality dimensions, on the one hand, and job satisfaction, on the other. The research was conducted within the conditions of transition, i.e., in the organization that will be under the organizational changes (such as privatization) in the following period. As transition may produce uncertainty of the job positions for the employees (especially within the large public-owned monopolistic enterprises), it could be considered that organizational changes, such as privatization, could affect job dissatisfaction to a significant extent. Data and Tools: The survey research was conducted within the large public-owned monopolistic enterprises in Serbia on the sample of 116 employees. Findings: The research results pointed out that the employees’ gender significantly shaped the correlation between all of the personality dimensions, on the one hand, and different facets of job satisfaction, on the other. Namely, in case of male employees, statistical significance was shown between Extraversion and Pay, Extraversion and Operating Conditions, Conscientiousness and Pay, Conscientiousness and Rewards, Neuroticism and Benefits. In case of female employees, the statistical significance was shown between Agreeableness and Benefits, Conscientiousness and Benefits and finally between Neuroticism and Supervision. Contribution: The obtained results may have practical implications in the form of providing the database for further improvement of the human resource management within the transitional economies, such as Serbian.
The rule-based insensitivity effect: a systematic review
Authors: Kissi Ama , Harte Colin , Hughes Sean , De Houwer Jan , Crombez Geert
Published: July 2020

Background

Adherence to inaccurate rules has been viewed as a characteristic of human rule-following (i.e., the rule-based insensitivity effect; RBIE) and has been thought to be exacerbated in individuals suffering from clinical conditions. This review intended to systematically examine these claims in adult populations.

Methodology

We screened 1464 records which resulted in 21 studies that were deemed eligible for inclusion. Each of these studies was examined to determine: (1) if there is evidence for the RBIE in adults and (2) if this effect is larger in those suffering from psychological problems compared to their non-suffering counterparts. In addition, we investigated how (3) different operationalizations of the RBIE, and (4) the external validity and risks of bias of the experimental work investigating this effect, might influence the conclusions that can be drawn from the current systematic review.

Results

(1) Out of the 20 studies that were relevant for examining if evidence exists for the RBIE in adults, only 11 were eligible for vote counting. Results showed that after the contingency change, the rule groups were more inclined to demonstrate behavior that was reinforced before the change, compared to their non-instructed counterparts. Critically, however, none of these studies examined if their no-instructions group was an adequate comparison group. As a result, this made it difficult to determine whether the effects that were observed in the rule groups could be attributed to the rules or instructions that were manipulated in those experiments. (2) The single study that was relevant for examining if adults suffering from psychological problems demonstrated larger levels of the RBIE, compared to their non-clinical counterparts, was not eligible for vote counting. As a result, no conclusions could be drawn about the extent to which psychological problems moderated the RBIE in that study. (3) Similar procedures and tasks have been used to examine the RBIE, but their precise parameters differ across studies; and (4) most studies report insufficient information to evaluate all relevant aspects affecting their external validity and risks of bias.

Conclusions

Despite the widespread appeal that the RBIE has enjoyed, this systematic review indicates that, at present, only preliminary evidence exists for the idea that adults demonstrate the RBIE and no evidence is available to assume that psychological problems exacerbate the RBIE in adults.

The systematic review was registered in PROSPERO (CRD42018088210).
Outstanding performance of an invasive alien tree Bischofia javanica relative to native tree species and implications for management of insular primary forests
Authors: Abe Tetsuto , Tanaka Nobuyuki , Shimizu Yoshikazu
Published: July 2020

Invasive alien tree species can exert severe impacts, especially in insular biodiversity hotspots, but have been inadequately studied. Knowledge of the life history and population trends of an invasive alien tree species is essential for appropriate ecosystem management. The invasive tree Bischofia javanica has overwhelmed native trees on Haha-jima Island in the Ogasawara Islands, Japan. We explored forest community dynamics 2 years after a typhoon damaged the Sekimon primary forests on Haha-jima Island, and predicted the rate of population increase of B. javanica using a logistic model from forest dynamics data for 19 years. During the 2 years after the typhoon, only B. javanica increased in population size, whereas populations of native tree species decreased. Stem diameter growth of B. javanica was more rapid than that of other tree species, including native pioneer trees. Among the understory stems below canopy trees of other species, B. javanica grew most rapidly and B. javanica canopy trees decreased growth of the dominant native Ardisia sieboldii. These competitive advantages were indicated to be the main mechanism by which B. javanica replaces native trees. The logistic model predicted that B. javanica would reach 30% of the total basal area between 2017 (in the eastern plot adjacent to a former B. javanica plantation) and 2057 (in the western plot distant from the plantation site), which is a maximum percentage allowing to eradicate under the present guideline of the National Forest. The results suggest immediate removal of B. javanica is required to preserve native biodiversity in these forests.
How to enhance primary school EFL-teacher curriculum-design competences: the Competence Unit Design Model (CUD Mod)
Authors:   Università degli Studi di Firenze (Italia), Capperucci Davide
Published: July 2020

This paper focuses on the development of curriculum design and methodological competences for pre-service and in-service EFL teachers in primary school, considered as essential aspects of the professionalism of teachers. In line with the national and international literature, it addresses some epistemological and methodological aspects of EFL curriculum design with particular reference to how this is dealt with in the Italian school system, even though most of the reflections and methodological proposals that are here presented could be considered useful for any school system. The paper proposes a competence design model, called CUD Mod, based on the “competence unit” framework, experimented in a variety of action-research projects conducted in Tuscan schools at primary and lower secondary level.
Fundamentos teórico-prácticos en torno a la inclusión del alumnado con discapacidad intelectual en el aula de lengua extranjera
Authors:   Universidad de Granada (España), Medina Sánchez Leopoldo , Pérez Valverde Cristina ,   Universidad de Granada (España)
Published: July 2020

El objetivo de este estudio es proporcionar una revisión teórico-práctica de la literatura referente al alumnado con discapacidad intelectual que aprende una lengua extranjera con el fin de ofrecer a los docentes de lenguas caminos para alcanzar una educación inclusiva de calidad y equitativa. Para ello, hemos realizado un análisis exhaustivo de las investigaciones y propuestas metodológicas más beneficiosas y actuales que se han llevado a cabo. De la misma manera, ponemos de relieve cómo el aprendizaje de idiomas contribuye no solo a una mejora académica, sino también a la inclusión sociocultural. Los estudios revisados incluyen tanto estudios de caso como programas de intervención específicos y propuestas pedagógicas. Los principales resultados ponen de relieve que los materiales didácticos empleados con este tipo de alumnado no son adecuados para el aprendizaje de idiomas. Paralelamente, estudios desarrollados en contextos bilingües arrojan resultados bastante sorprendentes: algunas personas con discapacidad intelectual pueden manifestar habilidades lingüísticas extraordinarias. Asimismo, el contexto canadiense aporta datos sugerentes gracias a la actuación de una docente bajo los principios de la inclusión generativa y el uso de una metodología basada en el diseño universal para el aprendizaje (DUA).
The use of discourse markers in oral discourse in EFL classroom by pre-service EFL teachers
Authors:   Western Norway University of Applied Sciences (Noruega), Kapranov Oleksandr
Published: July 2020

This article presents and discusses a computer-assisted case study of the use of discourse markers (further—‘DMs’) in oral discourse in English as a Foreign Language (EFL) by pre-service teachers in Norway. The aim of this case study is to explore the use of DMs by pre-service teachers (further referred to as ‘participants’) in EFL classroom by means of analysing the participants’ answers to the questionnaire that is designed to address the use of DMs in oral discourse in EFL after their school practice. The case study is informed by the view of DMs as “sequentially dependent elements that bracket units of talk” (Schiffrin, 1987: 31). The quantitative analysis of the participants’ questionnaires in statistical program SPSS version 18.0 (2009) indicates that the participants’ repertoire of DMs in their oral discourse in EFL classroom consists of such DMs as also, and, as, because, besides, but, especially, if, OK, or, so, and then. Additionally, the participants note that they do not use the following DMs during their teaching practice at school, e.g. indeed, moreover, and rather. These findings and their linguo-didactic implications will be further discussed in the article.
Estudio comparativo-causal sobre el éxito en la vida escolar en profesorado de lengua extranjera en formación
Authors:   Universidad de Málaga (España), Cardoso Pulido Manuel Jesús , Guijarro Ojeda Juan Ramón ,   Universidad de Málaga (España)
Published: July 2020

El objetivo de esta investigación se centra en estudiar el constructo “éxito en la vida escolar” en maestras y maestros de 4.º curso del Grado en Educación Primaria con mención en Lenguas Extranjeras (inglés) de la Universidad de Granada durante el periodo de prácticas externas. Para ello, hemos empleado y adaptado a nuestro contexto la herramienta rueda de la vida escolar (López y Valls, 2013) en 88 futuros docentes de lenguas. El foco de estudio lo hemos situado en la relación que se establece entre la variable dependiente (éxito en la vida escolar) con las variables independientes (género, lugar de nacimiento, profesión de los progenitores, tipo y zona del centro, y la motivación para cursar el grado). De forma general, los datos relativos a las medias procedentes de los 12 ítems analizados que recoge nuestro instrumento revelan que las relaciones sociales derivadas de la interacción con el alumnado de educación primaria y las compañeras y compañeros de prácticas tienen un peso preponderante. Sin embargo, el análisis de los datos pone de manifiesto una falta de formación en materia de liderazgo. De manera específica, los resultados aflorados indican que las maestras y maestros con ascendencia docente experimentan un bienestar mayor. Asimismo, los resultados arrojan datos significativos en torno a la importancia de las dimensiones sociales, afectivas y motivacionales dentro de la profesión y formación docente, y su estrecha relación con el éxito en la vida escolar
Variability in Glucocorticoid Prescribing for Rheumatoid Arthritis and the Influence of Provider Preference on Long‐Term Use of Glucocorticoids
Authors: George Michael D. , Baker Joshua F. , Wallace Beth , Chen Lang , Wu Qufei , Xie Fenglong , Yun Huifeng , Curtis Jeffrey R.
Published: July 2020

Objective

Glucocorticoids are recommended for short‐term use in rheumatoid arthritis (RA), but many patients continue receiving long‐term therapy. We evaluated the variability in glucocorticoid prescribing across rheumatologists to inform interventions to limit long‐term glucocorticoid use to the lowest dose necessary.

Methods

Two cohorts were created using Medicare data from 2006 to 2015. Using cohort 1 (RA patients receiving disease‐modifying antirheumatic drugs [DMARDs]), we calculated each rheumatologist’s “provider preference” for glucocorticoids (frequency of use compared to other providers), using the ratio of observed to expected number of patients receiving glucocorticoids to account for case mix. In cohort 2 (RA patients receiving stable DMARD therapy), we evaluated whether provider preference for glucocorticoids could independently predict use of ≥5 mg/day of glucocorticoids 6–9 months after initiation of DMARD therapy.

Results

Using cohort 1 (1,272,644 yearly observations; 385,597 patients), we calculated provider preference among 6,875 rheumatologists (28,936 yearly observations). Provider preference was highly variable, with physicians at the lowest and upper quartiles prescribing glucocorticoids 33% less often to 31% more often (25th and 75th percentiles, respectively) than expected. In cohort 2 (155,539 patients receiving stable DMARD therapy), provider preference was strongly associated with glucocorticoid use ≥5 mg/day at 6–9 months, with a predicted probability of use of 22% (95% confidence interval [95% CI] 21.7–22.7) versus 11% (95% CI 10.2–10.9) for a patient seeing a provider in the highest versus lowest quintile of preference.

Conclusion

Glucocorticoid prescribing for RA varies greatly among rheumatologists, and provider preference is one of the strongest predictors of a patient’s long‐term glucocorticoid use. These findings raise quality of care concerns and highlight the need for stronger evidence to guide RA treatment.
Impact of Psychiatric Comorbidity on Health Care Use in Rheumatoid Arthritis: A Population‐Based Study
Authors: Hitchon Carol A. , Walld Randy , Peschken Christine A. , Bernstein Charles N. , Bolton James M. , El‐Gabalawy Renée , Fisk John D. , Katz Alan , Lix Lisa M. , Marriott James , Patten Scott B. , Sareen Jitender , Singer Alexander , Marrie Ruth Ann
Published: July 2020

Objective

Psychiatric comorbidity is frequent in rheumatoid arthritis (RA) and complicates treatment. The present study was undertaken to describe the impact of psychiatric comorbidity on health care use (utilization) in RA.

Methods

We accessed administrative health data (1984–2016) and identified a prevalent cohort with diagnosed RA. Cases of RA (n = 12,984) were matched for age, sex, and region of residence with 5 controls (CNT) per case (n = 64,510). Within each cohort, we identified psychiatric morbidities (depression, anxiety, bipolar disorder, and schizophrenia [PSYC]), with active PSYC defined as ≥2 visits per year. For the years 2006–2016, annual rates of ambulatory care visits (mean ± SD per person) categorized by provider (family physician [FP], rheumatologist, psychiatrist, other specialist), hospitalization (% of cohort), days of hospitalization (mean ± SD), and dispensed drug types (mean ± SD per person) were compared among 4 groups (CNT, CNT plus PSYC, RA, and RA plus PSYC) using generalized linear models adjusted for age, sex, rural versus urban residence, income quintile, and total comorbidities. Estimated rates are reported with 95% confidence intervals (95% CIs). We tested within‐person and RA‐PSYC interaction effects.

Results

Subjects with RA were mainly female (72%) and urban residents (59%), with a mean ± SD age of 54 ± 16 years. Compared to RA without PSYC, RA with PSYC had more than additive (synergistic) visits (standardized mean difference [SMD] 10.92 [95% CI 10.25, 11.58]), hospitalizations (SMD 13% [95% CI 0.11, 0.14]), and hospital days (SMD 3.63 [95% CI 3.06, 4.19]) and were dispensed 6.85 more medication types (95% CI 6.43, 7.27). Cases of RA plus PSYC had increased visits to FPs (an additional SMD 8.92 [95% CI 8.35, 9.46] visits). PSYC increased utilization in within‐person models.

Conclusion

Managing psychiatric comorbidity effectively may reduce utilization in RA.
Clinical Scenario and Long‐Term Outcome of Childhood Takayasu Arteritis Undergoing 121 Endovascular Interventions: A Large Cohort Over a Fifteen‐Year Period
Authors: Fan Luyun , Yang Lirui , Wei Dongmei , Ma Wenjun , Lou Ying , Song Lei , Bian Jin , Zhang Huimin , Cai Jun
Published: July 2020

Objective

Evidence‐based studies on endovascular approaches for childhood Takayasu arteritis (TAK) are limited. Our objective was to present the largest current real‐world scenario for patients with childhood TAK undergoing interventions and their postinterventional outcomes.

Methods

Data were collected for patients with childhood TAK admitted from 2002 to 2017. Complication/reintervention‐free survival was projected by Kaplan‐Meier methods. Associated factors for intervention and predictors for postinterventional complications/reinterventions were assessed via regression models.

Results

Among 101 patients enrolled, 69 (68.3%) underwent 121 interventions (angioplasty 95, stenting 26) during a 3.1‐year follow‐up. Compared with the nonintervention group, the intervention group independently associated with a male population (odds ratio [OR] 0.27, P = 0.035) and type IV disease (OR 17.92, P = 0.001). Male sex also marginally indicated a risk for reintervention (hazard ratio [HR] 3.22, P = 0.05). Baseline retinopathy, delay in diagnosis, and descending thoracic aorta involvement were associated with stent insertion (P < 0.05). Hypertension secondary to renal artery stenosis (RAS; 59.4%) or mid‐aorta stenosis (MAS; 14.5%), heart failure (21.7%), and claudication (21.7%) were leading clinical hints for interventions. The technical success rate was 96.7%. During a median 2.88‐year of follow‐up after intervention, 36 lesions occurred with complications in 28 patients, and 22 lesions in 17 patients, particularly on the renal artery or mid‐aorta. The 5‐year complication‐free and reintervention‐free survivals were 50.7% and 65.8%, respectively. Peri‐interventional dual antiplatelet therapy (DAPT; HR 0.31), concurrent surgery (HR 26.5), and technical failure (HR 3.65) were independent predictors for complications (P < 0.05). Male sex (HR 2.52), retinopathy secondary to hypertension (HR 3.41), and pulmonary artery hypertension (PAH; HR 3.64) were baseline indicators for complications (P < 0.05).

Conclusion

Over two‐thirds of patients with childhood TAK require interventions, and the 5‐year complication‐free survival is 50.7%. Male sex, retinopathy, and PAH at baseline indicate the possibility of unfavorable outcomes. Interventions on MAS or RAS in childhood TAK raise specific concerns. DAPT peri‐intervention appears to protect patients with childhood TAK from postinterventional complications.
Impact of the 2019 European Alliance of Associations for Rheumatology/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus in a Multicenter Cohort Study of 133 Women With Undifferentiated Connective Tissue Disease
Authors: Radin Massimo , Schreiber Karen , Cecchi Irene , Bortoluzzi Alessandra , Crisafulli Francesca , de Freitas Cristiano M. , Bacco Beatrice , Rubini Elena , Foddai Silvia G. , Padovan Melissa , Gallo Cassarino Silvia , Franceschini Franco , Andrade Danieli , Benedetto Chiara , Govoni Marcello , Bertero Tiziana , Marozio Luca , Roccatello Dario , Andreoli Laura , Sciascia Savino
Published: July 2020

Objective

We aimed to investigate the impact of applying the 2019 European Alliance of Associations for Rheumatology (EULAR)/American College of Rheumatology (ACR) classification criteria for systemic lupus erythematosus (SLE) in a previously described cohort of women with undifferentiated connective tissue disease (UCTD).

Methods

This study included 133 women with UCTD. At the time of inclusion into the study, none of the patients met any classification criteria for other defined systemic connective tissue disease.

Results

When applying the 2019 EULAR/ACR classification criteria to the cohort, 22 patients (17%) fulfilled the classification criteria for SLE. Patients classified as having SLE had significantly higher frequencies of mucocutaneous manifestations (23% versus 5%; P = 0.007), arthritis (59% versus 17%; P < 0.001), isolated urine abnormalities (18% versus 1%; P < 0.001), and highly specific antibodies (50% versus 15%; P < 0.001) compared to the other patients with UCTD. At follow‐up, these patients were statistically significantly more likely to also meet the 1997 ACR revised SLE criteria and the Systemic Lupus International Collaborating Clinics (SLICC) criteria (18.2% versus 1.8%; P < 0.001) compared to the other UCTD patients.

Patients who were diagnosed as having SLE according to the ACR 1997 update of the SLE revised criteria and the SLICC criteria during the follow‐up scored higher on outcome measures when classified as having SLE according to the new 2019 EULAR/ACR classification criteria when compared to the other patients with UCTD (mean ± SD score 8.3 ± 3.7 versus 4.5 ± 4; P < 0.05).

Conclusion

When applying the 2019 EULAR/ACR criteria for SLE in a cohort of patients with UCTD, we observed that in up to 17% of cases the original classification could be challenged. New implementation will help to identify earlier patients at higher risk of developing more severe CTD manifestations.
Proposal of a modified subclassification system for stage III colorectal cancer: A multi‐institutional retrospective analysis
Authors: Shinto Eiji , Ike Hideyuki , Hida Jin‐ichi , Kobayashi Hirotoshi , Hashiguchi Yojiro , Hase Kazuo , Kishi Yoji , Ueno Hideki , Sugihara Kenichi
Published: July 2020

Aim

The prognostic value of the stage III subclassification system based on the Japanese Classification of Colorectal, Appendiceal, and Anal Carcinoma has not yet been clarified. This study aimed to develop a modified system with optimal risk stratification and compare its performance with the current staging systems.

Methods

Clinicopathological data from 6855 patients with stage III colorectal cancers who underwent D3 dissection were collected from a nationwide multicenter database. After determining patient survival rates across 13 divisions based on pathological N stage (N1, N2a, and N2b/N3) and tumor depth (T1, T2, T3, T4a, and T4b), except for T1N2a and T1N2b/N3 due to the small number, we categorized patients into three groups and developed a trisection staging system according to the Akaike information criterion. We then compared the Akaike information criterion of the developed system with those of the current staging systems.

Results

The T1N1[rank, 1] division (98.5%) had the most favorable prognosis in terms of 5‐year cancer‐specific survival, followed by T2N1[2] (93.9%), T2N2a[3] (92.0%), T3N1[4] (87.0%), T3N2a[5] (78.8%), T4aN1[6] (78.7%), T2N2b/N3[7] (77.8%), T4aN2a[8] (75.2%), T4bN1[9] (73.5%), T3N2b/N3[10] (64.7%), T4aN2b/N3[11] (61.5%), T4bN2b/N3[12] (43.0%), and T4bN2a[13] (42.5%). Compared to the categorizations of the Japanese and tumor‐node‐metastasis systems (Akaike information criterion, 22 684.6 and 22 727.1, respectively), the following stage categorizations were proven to be the most clinically efficacious: T1N1[1]‐T3N1[4], T3N2a[5]‐T4bN1[9], and T3N2b/N3[10]‐T4bN2a[13] (Akaike information criterion, 22 649.2).

Conclusion

The proposed modified system may be useful in the risk stratification of patients with stage III colorectal cancer who had undergone D3 dissection.
The comparison of health‐related quality of life and patient satisfaction between single‐incision and multiport laparoscopic colectomy for cancer: A sub‐study of a randomized, prospective clinical trial
Authors: Ohya Hiroki , Watanabe Jun , Suwa Yusuke , Suwa Hirokazu , Ozawa Mayumi , Ishibe Atsushi , Fujii Shoichi , Kubota Kazumi , Kunisaki Chikara , Endo Itaru
Published: July 2020

Aim

The present study clarified the effect on the health‐related quality of life and patient satisfaction of single‐incision laparoscopic colectomy compared with multiport laparoscopic colectomy for colorectal cancer.

Methods

We conducted a multicenter, randomized, control trial comparing single‐incision and multiport laparoscopic colectomy for colon cancer. We performed a pre‐planned secondary analysis of health‐related quality of life and patient satisfaction data of 200 patients. Health‐related quality of life was evaluated using the Japanese 36‐item Short Form Health Survey (SF‐36) version 2.0 before surgery and at 1 month after surgery. Patient satisfaction was compared using seven questionnaires at 1 month after surgery.

Results

One hundred patients were assigned to each group. After excluding 18 patients (9.0%) who did not complete the SF‐36, 182 patients (91.0%) were included in the analysis (92 cases of single‐incision laparoscopic colectomy and 90 cases of multiport laparoscopic colectomy). The SF‐36 scores at 1 month after surgery were not significantly different between the two arms. The role physical, bodily pain, vitality and physical component summary were significantly lower at 1 month after surgery than before in both groups. However, the role emotional was significantly lower after surgery than before only in the single‐incision laparoscopic colectomy group. In terms of patient satisfaction at 1 month after surgery, there were no significant differences in any of the seven items on the questionnaire.

Conclusions

Single‐incision laparoscopic colectomy was similar to multiport laparoscopic colectomy in terms of health‐related quality of life and patient satisfaction. However, single‐incision laparoscopic colectomy may be inferior than multiport laparoscopic colectomy in terms of the role emotional.
Development of Artificial Neural Network System to Recommend Process Conditions of Injection Molding for Various Geometries
Authors: Lee Chihun , Na Juwon , Park Kyongho , Yu Hyeonjae , Kim Jongsun , Choi Kwonil , Park Dongyong , Park Seongjin , Rho Junsuk , Lee Seungchul
Published: July 2020

This study combines an artificial neural network (ANN) and a random search to develop a system to recommend process conditions for injection molding. Both simulation and experimental results are collected using a mixed sampling method that combines Taguchi and random sampling. The dataset consists of 3600 simulations and 476 experiments from 36 different molds. Each datum has five process and 15 geometry features as input and one weight feature as output. Hyper‐parameter tuning is conducted to find the optimal ANN model. Then, transfer learning is introduced, which allows the use of simultaneous experimental and simulation data to reduce the error. The final prediction model has a root mean‐square error of 0.846. To develop a recommender system, random search is conducted using the trained ANN forward model. As a result, the weight‐prediction model based on simulated data has a relative error (RE) of 0.73%, and the weight prediction using the transfer model has an RE of 0.662%. A user interface system is also developed, which can be used directly with the injection‐molding machine. This method enables the setting of process conditions that yield parts having weights close to the target, by considering only the geometry and target weight.
The opportunity for outcrossing varies across the geographic range of the primarily selfingClarkia xantianassp.parviflora
Authors: Ruane Lauren G. , Mangum Samantha M. , Horner Kaitlyn M. , Moeller David A.
Published: July 2020

Premise

The timing of self‐fertilization has potentially important consequences for the trajectory of mating system evolution, the opportunity for outcrossing, and the maintenance of genetic variation in populations. For primarily selfing taxa, it remains poorly understood as to how floral variation influences the opportunity for outcrossing and whether those attributes vary among populations across geographic ranges.

Methods

We examined variation in floral traits (herkogamy, protandry, flower size, stigma stage at anthesis, timing of stigma receptivity) in seven populations ofClarkia xantianassp.parviflora, a primarily selfing taxon, spanning from the western to eastern margins of its distribution. We also performed experimental emasculations and pollinations (followed by stigma severing) to quantify the extent of opportunities for outcrossing across flower development.

Results

There was marked among‐population variation in all floral traits, particularly between far eastern and western populations. Emasculation experiments showed that the eastern populations had minimal autonomous selfing, but western populations had high rates of selfing within 24 h after anthesis. Population variation in autofertility was significantly predicted by floral trait variation, especially protandry and petal size.

Conclusions

Greater protandry both extended the time over which outcrossing could potentially occur and reduced the probability of autonomous selfing, suggesting that there may be a tradeoff that results in fitness loss when pollinator visits are not common. The east‐west pattern of differentiation in some floral traits parallels that of postglacial range expansion, suggesting that selection on the mating system may have been strong in the process of range expansion.
Knobloch syndrome in a patient from Chile
Authors: Nakousi‐Capurro Nicole , Huserman Jonathan , Castillo Silvia , Herrera Luisa , Romero Pablo , Pizarro Felipe , Quezada Cristian , Cea Francisco
Published: July 2020

Knobloch Syndrome (KS) is a rare autosomal recessive hereditary disease. Despite its clinical heterogeneity, it is characterized by vitreoretinal degeneration and high myopia, with or without occipital skull defects. It is caused by mutations in the COL18A1 gene, which codifies for collagen XVIII, present in retina and vascular endothelium. Since the first description of the disease by doctors Knobloch and Layer in 1972, over 100 cases and 20 pathogenic or likely pathogenic mutations have been reported. We present the case of a child born from a consanguineous couple in Chile with congenital high myopia and dysmorphisms without an occipital skull defect. Whole exome sequencing analysis revealed an inherited homozygous variant in COL18A1, c.4224_4225delinsC, p.Pro1411Leufs*35.
Integrating Time‐Resolved Imaging Information by Single‐Luminophore Dual Thermally Activated Delayed Fluorescence
Authors: Luo Mengkai , Li Xuping , Ding Longjiang , Baryshnikov Gleb , Shen Shen , Zhu Mingjie , Zhou Lulu , Zhang Man , Lu Jianjun , Ågren Hans , Wang Xu‐dong , Zhu Liangliang
Published: July 2020

The fact that the lifetime of photoluminescence is often difficult to access because of the weakness of the emission signals, seriously limits the possibility to gain local bioimaging information in time‐resolved luminescence probing. We aim to provide a solution to this problem by creating a general photophysical strategy based on the use of molecular probes designed for single‐luminophore dual thermally activated delayed fluorescence (TADF). The structural and conformational design makes the dual TADF strong in both diluted solution and in an aggregated state, thereby reducing sensitivity to oxygen quenching and enabling a unique dual‐channel time‐resolved imaging capability. As the two TADF signals show mutual complementarity during probing, a dual‐channel means that lifetime mapping is established to reduce the time‐resolved imaging distortion by 30–40 %. Consequently, the leading intracellular local imaging information is serialized and integrated, which allows comparison to any single time‐resolved signal, and leads to a significant improvement of the probing capacity.
Oral surgery with nasotracheal intubation in a patient with ectodermal dysplasia
Authors: Nanegrungsunk D. , Jericho B. G.
Published: July 2020

Ectodermal dysplasias are a rare group of heritable disorders involving the ectodermal derivatives with only a few published reports involving its anaesthetic management. We present the case of a 16‐year‐old boy with ectodermal dysplasia presented for elective oral surgery under general anaesthesia with a surgeon preference for nasotracheal intubation to provide adequate surgical exposure. The patient had successful nasal flexible bronchoscopic intubation despite challenging tracheal intubation conditions. We summarise previous case reports and discuss anaesthetic considerations in ectodermal dysplasia , including reduced mucus production in the respiratory tract, laryngeal incompetence, potential for difficult tracheal intubation and hyperthermia from reduced or absent sweat glands.
Synthesis of acetamides via oxidative C–C bond cleavage of ketones catalyzed by Cu‐immobilized magnetic nanoparticles
Authors: Yazdani Elahe , Pazoki Farzane , Salamatmanesh Arefe , Nejad Masoume Jadidi , Miraki Maryam Kazemi , Heydari Akbar
Published: July 2020

Copper supported on magnetite nanoparticles modified with environmentally friendly ligand tricine was devised for synthesis of acetamides via C–C oxidative cleavage of ketones with amines. The catalyst was characterized using different techniques, including Fourier transform infrared, X‐ray diffraction, scannin electron microscopy, vibrating sample magnetometry, thermogravimetric analysis, and energy dispersive x‐ray spectroscopy. The protocol showed relatively high yields of acetamide products. Furthermore, the magnetic recovery of the catalyst rendered the overall process fast and efficient. It was used in the reaction for six consecutive cycles with negligible loss of catalytic activity. This research is the first report of application of magnetic nanocatalysts for synthesis of acetamides from ketones of low activity through a C–C bond cleavage strategy.
Graphene nanoplatelets composite membranes for thermal comfort enhancement in performance textiles
Authors: Bonetti Lorenzo , Fiorati Andrea , Serafini Andrea , Masotti Guido , Tana Francesca , D'Agostino Agnese , Draghi Lorenza , Altomare Lina , Chiesa Roberto , Farè Silvia , Bianchi Massimiliano , Rizzi Laura Giorgia , De Nardo Luigi
Published: July 2020

The advent of 2D nanostructured materials as advanced fillers for polymer matrix composites has opened the doors to a plethora of new industrial applications requiring both electric and thermal management. Unique properties, in fact, can arise from accurate selection and processing of 2D fillers and their matrix. Here, we report an innovative family of nanocomposite membranes based on polyurethane (PU) and graphene nanoplatelets (GNPs), designed to improve thermal comfort in functional textiles. GNP particles were thoroughly characterized (through Raman, atomic force microscopy, high‐resolution TEM, scanning electron microscope), and showed high crystallinity (ID/IG = 0.127), low thickness (D50 < 6–8 layers), and high lateral dimensions (D50 ≈ 3 μm). When GNPs were loaded (up to 10% wt/wt) into the PU matrix, their homogeneous dispersion resulted in an increase of the in‐plane thermal conductivity of composite membranes up to 471%. The thermal dissipation of membranes, alone or coupled with cotton fabric, was further evaluated by means of an ad hoc system designed to simulate a human forearm. The results obtained provide a new strategy for the preparation of membranes suitable for technical textiles, with improved thermal comfort.
If the archaeological context is missing: the use of LiDAR prospection to uncover features at the medieval Christian position on Malvecino Hill (Alcalá de Henares, Spain)
Authors: Ramírez Galán Mario
Published: July 2020

The ongoing study of the Andalusian castle of Alcalá la Vieja (Alcalá de Henares, Madrid, Spain) continues to provide new insights about this Muslim fortress. However, the investigation of other battlefield locations around this stronghold, such as Malvecino Hill, have remained in the background. As the site where the Christian army built a temporary castle, Malvecino played a decisive role during the siege and conquest of Alcalá la Vieja in 1118 and is a strong candidate for archaeological study.

Some early archaeological prospections carried out at Malvecino in the 1970s corroborated the existence of medieval remains. Scholars have debated whether those remains derive from the fortress built by the Christians or to an earlier settlement. Unfortunately, those artefacts and features disappeared and are not available for additional investigation.

Given the lack of archeological context, our investigation included the process of locating potential archaeological features in Malvecino Hill using both aerial photography and light detection and ranging (LiDAR) datasets. This article highlights the value of LiDAR prospection as a preliminary step to fieldwork and describes two early medieval structures on Malvecino Hill that were newly revealed by our LiDAR visualization.
An evaluation of parent implemented web‐based behavioral skills training for firearm safety
Authors: Novotny Marissa A. , Miltenberger Raymond G. , Frederick Katelyn , Maxfield Trevor C.
Published: July 2020

Behavioral skills training (BST) is effective for teaching safety skills but often requires a behavior analyst to conduct the training, which can make it costly and inaccessible for most parents. Parent‐conducted BST may allow for children to receive training without the need for a trained behavior analyst. Manualized training from a website could allow parents access to needed material at a low cost. This study evaluated a web‐based manualized intervention implemented by parents for teaching firearm safety skills using BST. We used a multiple‐probe across participants design to assess the effectiveness of parent‐conducted BST. Results indicate that three children acquired the safety skills after parent‐conducted BST alone, and the other three children required experimenter‐conducted IST.