bluuebunny/crossref_metadata_2025 huggingface dataset:
TET2 rs1548483 SNP Associating with Susceptibility to Molecularly Annotated Polycythemia Vera and Primary Myelofibrosis
Authors: Lighezan Diana L. , Bojan Anca S. , Iancu Mihaela , Pop Raluca M. , Gligor-Popa Ștefana , Tripon Florin , Cosma Adriana S. , Tomuleasa Ciprian , Dima Delia , Zdrenghea Mihnea , Fetica Bogdan , Ioniță Ioana , Gaál Ildikó O. , Vișan Simona , Mirea Andreea-Manuela , Popp Radu A. , Florea Mira , Araniciu Cătălin , Petrescu Lucian , Pop Ioan V. , Bănescu Claudia , Trifa Adrian P.
Published: December 2020

Background: The complexity of myeloproliferative neoplasms (MPNs) cannot be characterized by acquired somatic mutations alone. Individual genetic background is thought to contribute to the development of MPNs. The aim of our study was to assess the association between the TET2 rs1548483 single nucleotide polymorphism (SNP) and the susceptibility to polycythemia vera (PV), essential thrombocythemia (ET), primary myelofibrosis (PMF) or chronic myeloid leukemia (CML). Methods: We evaluated the TET2 rs1548483 SNP through real-time PCR in 1601 MPN patients out of which 431 with PV, 688 with TE, 233 with PMF, 249 with CML and 197 controls. We included only patients with a molecularly proven driver mutation, such as JAK2 V617F, CALR or BCR-ABL1. Results: Significant association between TET2 rs154843 variant allele and JAK2 V617F-positive PV and PMF (OR = 1.70; 95% CI: 1.01–2.91; p-value = 0.046, and OR = 2.04; 95% CI: 1.10–3.77; p-value = 0.024, respectively), and type 2 CALR-positive PMF (OR = 2.98; 95% CI: 1.12–7.93; p-value = 0.035) was noted. Conclusions: The TET2 rs1548483 SNP is associated with the susceptibility to molecularly annotated PV and PMF.
Study of the Stiffness of the Bitumen Emulsion Based Cold Recycling Mixes for Road Base Courses
Authors: Konieczna Katarzyna , Pokorski Piotr , Sorociak Wojciech , Radziszewski Piotr , Żymełka Dawid , Król Jan
Published: December 2020

The benefits of the use of cold recycling mixtures (CRMs) in pavement rehabilitation are associated with both the reduction of natural resource consumption by replacing them with recycled materials and the reduction of energy consumption during their production and paving. The evolution of the stiffness of CRMs in road construction and the fatigue life of pavements with CRM base layers are still being investigated. In this paper, CRMs with 1% cement content, called bitumen-stabilized materials with bitumen emulsion (BSM-Es), were examined. Mixtures that were differentiated in terms of Reclaimed Asphalt Pavement (RAP) content, as well as the amount and type of bitumen emulsions, were subjected to indirect tensile stiffness modulus (ITSM) tests at 5 °C, 13 °C, and 20 °C. The thermal sensitivities of the BSM-E mixtures were analyzed. BSM-E mixture stiffness modulus levels at various temperatures were determined using a statistical approach. On the basis of the results obtained, a discussion on the mechanistic-empirical design of flexible pavements with BSM-E base layers is presented. The potential benefits of using BSM-E materials in road construction in certain aspects of pavement life are indicated.
A Novel Micro-Displacement Sensor Based on Double Optical Fiber Probes Made through Photopolymer Materials
Authors: Zhang Fuzheng , Lin Qijing , Zhu Liangquan , Zhao Na , Han Feng , Zhao Libo , Jiang Zhuangde
Published: December 2020

In this paper, a novel micro-displacement sensor with double optical fiber probes is proposed and designed, which can realize the highly sensitive sensing of longitudinal or lateral micro-displacements. The optical fiber probes are made through photopolymer formulation, and the effects of reaction time and optical power on the growth length of the probe are illustrated. The relationship between light intensity and longitudinal micro-displacement is a power function in the range of 0–100 μm at room temperature with a correlation coefficient of 98.92%. For lateral micro-displacement, the sensitivity is −2.9697 dBm/μm in the range of 0–6 μm with a linear fit of 99.61%. In addition, the linear correlation coefficient decreases as the initial longitudinal distance increases, and the function of these correlation coefficients is also linear with a linearity of 96.14%. This sensor has a simple manufacturing process, low cost, high sensitivity, and fast response speed. It is suitable for harsh environments such as strong electromagnetic interference and corrosivity, and has a broad application prospect in the field of micro-displacement sensing.
Gas Permeation Characteristics of TiO2-ZrO2-Aromatic Organic Chelating Ligand (aOCL) Composite Membranes
Authors: Tachibana Takashi , Yoshioka Tomohisa , Nakagawa Keizo , Shintani Takuji , Kamio Eiji , Matsuyama Hideto
Published: December 2020

Methyl gallate (MG) and ethyl ferulate (EF) with a benzene ring were separately used as aromatic organic chelating ligands (aOCLs) to prepare two versions of TiO2-ZrO2-aOCL composite sols via hydrolysis and polycondensation reactions with titanium(IV) isopropoxide (Ti(OC3H7)4) and zirconium(IV) butoxide (Zr(OC4H9)4). Thermogravimetric and FT-IR analysis of dry gels revealed that aromatic rings were present in the residual organic matter when the gel was fired under nitrogen at 300 °C. In X-ray diffraction (XRD) measurements, the TiO2-ZrO2 composite material prepared using these two aOCLs showed an amorphous structure with no crystalline peaks for TiO2 and ZrO2. In N2 adsorption/desorption measurements at 77 K, the TiO2-ZrO2 samples using the aOCLs as a template appeared porous with a larger specific surface area than TiO2-ZrO2 without aOCL. TiO2-ZrO2-aOCL composite membranes were prepared by coating and firing TiO2-ZrO2-aOCL sol onto a SiO2 intermediate layer using an α-alumina porous tube as a substrate. Compared with the TiO2-ZrO2 membrane, the TiO2-ZrO2-aOCL membranes had higher gas permselectivity. The TiO2-ZrO2-EF membrane showed a He permeance of 2.69 × 10−6 mol m−2 s−1 Pa−1 with permeance ratios of He/N2 = 10.6 and He/CF4 = 163, while the TiO2-ZrO2-MG membrane revealed a bit less He permeance at 8.56 × 10−7 mol m−2 s−1 Pa−1 with greater permeance ratios of He/N2 = 61.7 and He/CF4 = 209 at 200 °C. A microporous TiO2-ZrO2 amorphous structure was obtained by introducing aOCL. The differences in the side chains of each aOCL could possibly account for the differences in the microporous structures of the resultant TiO2-ZrO2-aOCL membranes.
A Meta-Analysis of the Impact of Resveratrol Supplementation on Markers of Renal Function and Blood Pressure in Type 2 Diabetic Patients on Hypoglycemic Therapy
Authors: Nyambuya Tawanda M. , Nkambule Bongani B. , Mazibuko-Mbeje Sithandiwe E. , Mxinwa Vuyolwethu , Mokgalaboni Kabelo , Orlando Patrick , Silvestri Sonia , Louw Johan , Tiano Luca , Dludla Phiwayinkosi V.
Published: December 2020

Evidence on the beneficial effects of resveratrol supplementation on cardiovascular disease-related profiles in patients with type 2 diabetes (T2D) is conflicting, while its impact on renal function and blood pressure measurements remains to be established in these patients. The current meta-analysis included randomized controlled trials (RCTs) reporting on the impact of resveratrol supplementation on markers of renal function and blood pressure in patients with T2D on hypoglycemic medication. Electronic databases such as MEDLINE, Cochrane Library, Scopus, and EMBASE were searched for eligible studies from inception up to June 2020. The random and fixed effects model was used in the meta-analysis. A total of five RCTs met the inclusion criteria and involved 388 participants with T2D. Notably, most of the participants were on metformin therapy, or metformin in combination with other hypoglycemic drugs such as insulin and glibenclamide. Pooled estimates showed that resveratrol supplementation in patients with T2D lowered the levels of fasting glucose (SMD: −0.06 [95% CI: −0.24, 0.12]; I2 = 4%, p = 0.39) and insulin (SMD: −0.08 [95% CI: −0.50, 0.34], I2 = 73%, p = 0.002) when compared to those on placebo. In addition, supplementation significantly lowered systolic blood pressure (SMD: −5.77 [95% CI: −8.61, −2.93], I2 = 66%, p = 0.02) in these patients. Although resveratrol supplementation did not affect creatinine or urea levels, it reduced the total protein content (SMD: −0.19 [95% CI: −0.36, −0.02]; I2 = 91%, p = 0.001). In all, resveratrol supplementation in hypoglycemic therapy improves glucose control and lowers blood pressure; however, additional evidence is necessary to confirm its effect on renal function in patients with T2D.
Compressed Air-Driven Continuous-Flow Thermocycled Digital PCR for HBV Diagnosis in Clinical-Level Serum Sample Based on Single Hot Plate
Authors: Wang Kangning , Li Bin , Wu Wenming
Published: December 2020

We report a novel compressed air-driven continuous-flow digital PCR (dPCR) system based on a 3D microfluidic chip and self-developed software system to realize real-time monitoring. The system can ensure the steady transmission of droplets in long tubing without an external power source and generate stable droplets of suitable size for dPCR by two needles and a narrowed Teflon tube. The stable thermal cycle required by dPCR can be achieved by using only one constant temperature heater. In addition, our system has realized the real-time detection of droplet fluorescence in each thermal cycle, which makes up for the drawbacks of the end-point detection method used in traditional continuous-flow dPCR. This continuous-flow digital PCR by the compressed air-driven method can meet the requirements of droplet thermal cycle and diagnosis in a clinical-level serum sample. Comparing the detection results of clinical samples (hepatitis B virus serum) with commercial instruments (CFX Connect; Bio Rad, Hercules, CA, USA), the linear correlation reached 0.9995. Because the system greatly simplified the traditional dPCR process, this system is stable and user-friendly.
Cytotoxic, Apoptosis-Inducing Activities, and Molecular Docking of a New Sterol from Bamboo Shoot Skin Phyllostachys heterocycla var. pubescens
Authors: Abdelhameed Reda F. A. , Nafie Mohamed S. , Ibrahim Ahmed K. , Yamada Koji , Abdel-Kader Maged S. , Ibrahim Amany K. , Ahmed Safwat A. , Badr Jihan M. , Habib Eman S.
Published: December 2020

Phytochemical screening of nonpolar fractions from the methanol extract of the Bamboo shoot skin Phyllostachys heterocycla var. pubescens resulted in the isolation of a new sterol-glucoside-fatty acid derivative (6’-O-octadeca-8″,11″-dienoyl)-sitosterol-3-O-β-d-glucoside (1), together with six known compounds. The chemical structures of the pure isolated compounds were deduced based on different spectral data. The isolated compounds were assessed to determine their cytotoxic activity, and the results were confirmed by determining their apoptotic activity. Compound 1 was more cytotoxic against the MCF-7 cells (IC50 = 25.8 µM) compared to Fluorouracil (5-FU) (26.98 µM), and it significantly stimulated apoptotic breast cancer cell death with 32.6-fold (16.63% compared to 0.51 for the control) at pre-G1 and G2/M-phase cell cycle arrest and blocked the progression of MCF-7 cells. Additionally, RT-PCR results further confirmed the apoptotic activity of compound 1 by the upregulation of proapoptotic genes (P53; Bax; and caspases 3, 8, and 9) and downregulation of the antiapoptotic genes (BCL2). Finally, the identified compounds, especially 1, were found to have high binding affinity towards both tyrosine-specific protein kinase (TPK) and vascular endothelial growth factor receptor (VEGFR-2) through the molecular docking studies that highlight its mode of action.
Microstructure and Properties of Mechanical Alloying Al-Zr Coating by High Current Pulsed Electron Beam Irradiation
Authors: Li Xiangcheng , Liu Huiru , Tian Nana , Zhang Conglin , Lyu Peng , Guan Qingfeng
Published: December 2020

The “HOPE-I” type high-current pulsed electron beam (HCPEB) equipment was used to irradiate the pure aluminum material with Zr coating preset by ball milling to realize the alloying of a Zr–Al coating surface. The microstructure and phase analysis were conducted by XRD, SEM, and TEM. The experimental results show that after Zr alloying on the Al surface by HCPEB, a layer of 15 μm was formed on the surface of the sample, which was mainly composed of Zr and Al–Zr intermetallic compounds. A large number of Al3Zr (Ll2) particles was uniformly distributed in the alloyed layer, and the Al grains were obviously refined. In addition, the surface hardness and corrosion resistance of the samples were improved significantly after HCPEB irradiation.
Impedimetric Detection of Femtomolar Levels of Interleukin 6, Interleukin 8, and Tumor Necrosis Factor Alpha Based on Thermally Modified Nanotubular Titanium Dioxide Arrays
Authors: Arkusz Katarzyna , Paradowska Ewa
Published: December 2020

An inexpensive, easy to prepare, and label-free electrochemical impedance spectroscopy-based biosensor has been developed for the selective detection of human interleukin 6 (IL-6), interleukin 8 (CXCL8, IL-8), and tumor necrosis factor (TNFα)—potential inflammatory cancer biomarkers. We describe a, so far, newly developed and unexplored method to immobilize antibodies onto a titanium dioxide nanotube (TNT) array by physical adsorption. Immobilization of anti-IL-6, anti-IL-8, and anti-TNFα on TNT and the detection of human IL-6, IL-8, and TNFα were examined using electrochemical impedance spectroscopy (EIS). The impedimetric immunosensor demonstrates good selectivity and high sensitivity against human biomarker analytes and can detect IL-6, IL-8, and TNFα at concentrations as low as 5 pg/mL, equivalent to the standard concentration of these proteins in human blood. The calibration curves evidenced that elaborated biosensors are sensitive to three cytokines within 5 ÷ 2500 pg/mL in the 0.01 M phosphate-buffered saline solution (pH 7.4).
Biocompatibility and Antibacterial Properties of ZnO-Incorporated Anodic Oxide Coatings on TiZrNb Alloy
Authors: Oleshko Oleksandr , Husak Yevheniia , Korniienko Viktoriia , Pshenychnyi Roman , Varava Yuliia , Kalinkevich Oksana , Pisarek Marcin , Grundsteins Karlis , Pogorielova Oksana , Mishchenko Oleg , Simka Wojciech , Viter Roman , Pogorielov Maksym
Published: December 2020

In a present paper, we demonstrate novel approach to form ceramic coatings with incorporated ZnO nanoparticles (NPs) on low modulus TiZrNb alloy with enhanced biocompatibility and antibacterial parameters. Plasma Electrolytic Oxidation (PEO) was used to integrate ZnO nanoparticles (average size 12–27 nm), mixed with Ca(H2PO2)2 aqueous solution into low modulus TiZrNb alloy surface. The TiZrNb alloys with integrated ZnO NPs successfully showed higher surface porosity and contact angle. XPS investigations showed presence of Ca ions and absence of phosphate ions in the PEO modified layer, what explains higher values of contact angle. Cell culture experiment (U2OS type) confirmed that the surface of as formed oxide-ZnO NPs demonstrated hydrophobic properties, what can affect primary cell attachment. Further investigations showed that Ca ions in the PEO coating stimulated proliferative activity of attached cells, resulting in competitive adhesion between cells and bacteria in clinical situation. Thus, high contact angle and integrated ZnO NPs prevent bacterial adhesion and considerably enhance the antibacterial property of TiZrNb alloys. A new anodic oxide coating with ZnO NPs could be successfully used for modification of low modulus alloys to decrease post-implantation complications.
A Novel Design of a 3D Racetrack Memory Based on Functional Segments in Cylindrical Nanowire Arrays
Authors: Rial Javier , Proenca Mariana P.
Published: December 2020

A racetrack memory is a device where the information is stored as magnetic domains (bits) along a nanowire (track). To read and record the information, the bits are moved along the track by current pulses until they reach the reading/writing heads. In particular, 3D racetrack memory devices use arrays of vertically aligned wires (tracks), thus enhancing storage density. In this work, we propose a novel 3D racetrack memory configuration based on functional segments inside cylindrical nanowire arrays. The innovative idea is the integration of the writing element inside the racetrack itself, avoiding the need to implement external writing heads next to the track. The use of selective magnetic segments inside one nanowire allows the creation of writing and storage sections inside the same track, separated by chemical constraints identical to those separating the bits. Using micromagnetic simulations, our study reveals that if the writing section is composed of two segments with different coercivities, one can reverse its magnetization independently from the rest of the memory device by applying an external magnetic field. Spin-polarized current pulses then move the information bits along selected tracks, completing the writing process by pushing the new bit into the storage section of the wire. Finally, we have proven the efficacy of this system inside an array of 7 nanowires, opening the possibility to use this configuration in a 3D racetrack memory device composed of an array of thousands of nanowires produced by low-cost and high-yield template-electrodeposition methods.
Omega-3 Fatty Acids for Sport Performance—Are They Equally Beneficial for Athletes and Amateurs? A Narrative Review
Authors: Thielecke Frank , Blannin Andrew
Published: December 2020

Omega-3 fatty acids, specifically eicosapentanoic acid (EPA, 20:5n-3) and docosahexanoic acid (DHA, 22:6n-3) are receiving increasing attention in sports nutrition. While the usual focus is that of athletes, questions remain if the different training status between athletes and amateurs influences the response to EPA/DHA, and as to whether amateurs would benefit from EPA/DHA supplementation. We critically examine the efficacy of EPA/DHA on performance, recovery and injury/reduced risk of illness in athletes as well as amateurs. Relevant studies conducted in amateurs will not only broaden the body of evidence but shed more light on the effects of EPA/DHA in professionally trained vs. amateur populations. Overall, studies of EPA/DHA supplementation in sport performance are few and research designs rather diverse. Several studies suggest a potentially beneficial effect of EPA/DHA on performance by improved endurance capacity and delayed onset of muscle soreness, as well as on markers related to enhanced recovery and immune modulation. The majority of these studies are conducted in amateurs. While the evidence seems to broadly support beneficial effects of EPA/DHA supplementation for athletes and more so in amateurs, strong conclusions and clear recommendations about the use of EPA/DHA supplementation are currently hampered by inconsistent translation into clinical endpoints.
Self-Assembled Disulfide Bond Bearing Paclitaxel—Camptothecin Prodrug Nanoparticle for Lung Cancer Therapy
Authors: Gao Jingyan , Ma Xiaodong , Zhang Lirong , Yan Jiaqi , Cui Huaguang , Zhang Yuezhou , Wang Dongqing , Zhang Hongbo
Published: December 2020

Self-assembled prodrugs (SAPDs), which combine prodrug strategy and the merits of self-assembly, not only represent an appealing type of therapeutics, enabling the spontaneous organization of supramolecular nanocomposites with defined structures in aqueous environments, but also provide a new method to formulate existing drugs for more favorable outcomes. To increase drug loading and combination therapy, we covalently conjugated paclitaxel (PTX) and camptothecin (CPT) through a disulfide linker into a prodrug, designated PTX-S-S-CPT. The successful production of PTX-S-S-CPT prodrug was confirmed by nuclear magnetic resonance (NMR) and high-resolution mass spectrometry (HRMS). This prodrug spontaneously undergoes precipitation in aqueous surroundings. Taking advantage of a flow-focusing microfluidics platform, the prodrug nanoparticles (NPs) have good monodispersity, with good reproducibility and high yield. The as-prepared prodrug NPs were characterized with dynamic light scattering (DLS) and transmission electron microscopy (TEM), demonstrating spherical morphology of around 200 nm in size. In the end, the self-assembled NPs were added to mouse embryonic fibroblast (MEF), mouse lung adenocarcinoma and Lewis lung carcinoma (LLC) cell lines, and human non-small cell lung cancer cell line A549 to evaluate cell viability and toxicity. Due to the redox response with a disulfide bond, the PTX-S-S-CPT prodrug NPs significantly inhibited cancer cell growth, but had no obvious toxicity to healthy cells. This prodrug strategy is promising for co-delivery of PTX and CPT for lung cancer treatment, with reduced side effects on healthy cells.
An AGI Modifying Its Utility Function in Violation of the Strong Orthogonality Thesis
Authors: Miller James D. , Yampolskiy Roman , Häggström Olle
Published: December 2020

An artificial general intelligence (AGI) might have an instrumental drive to modify its utility function to improve its ability to cooperate, bargain, promise, threaten, and resist and engage in blackmail. Such an AGI would necessarily have a utility function that was at least partially observable and that was influenced by how other agents chose to interact with it. This instrumental drive would conflict with the strong orthogonality thesis since the modifications would be influenced by the AGI’s intelligence. AGIs in highly competitive environments might converge to having nearly the same utility function, one optimized to favorably influencing other agents through game theory. Nothing in our analysis weakens arguments concerning the risks of AGI.
Operational Resilience Disclosures by Banks: Analysis of Annual Reports
Authors: Leo Martin
Published: December 2020

An array of developments impacting the financial services industry, such as increasing complexity, interconnectedness, third party dependencies and digitalization, means operational resilience will remain a significant area of concern for policy makers, investors and customers. The purpose of this study is to evaluate if banks are disclosing information on their operational resilience risk. The study initially reviews the regulatory landscape for operational resiliency. The recent annual reports of the GSIB banks are reviewed to identify if they have made references to operational resilience. Through text mining, a frequency analysis of terms related to operational resilience was done, followed by an evaluation to understand the existence of relationships between these terms. The study shows that the regulatory guidance for operational resilience is still evolving with much of the current impetus on cybersecurity. There is a notable gap between banks that have reported on operational resiliency and those that have not, with a few patterns visible. Research in the area of operational resilience is relatively new and limited, and this research for the first time analyses the disclosures related to operational resilience in annual reports. Further, for policymakers, it highlights the disparity in disclosures around this relatively new area of risk, thus calling for additional regulatory guidance.
Hierarchical Spatial-Spectral Feature Extraction with Long Short Term Memory (LSTM) for Mineral Identification Using Hyperspectral Imagery
Authors: Zhao Huijie , Deng Kewang , Li Na , Wang Ziwei , Wei Wei
Published: December 2020

Deep learning models are widely employed in hyperspectral image processing to integrate both spatial features and spectral features, but the correlations between them are rarely taken into consideration. However, in hyperspectral mineral identification, not only the spectral and spatial features of minerals need to be considered, but also the correlations between them are crucial to further promote identification accuracy. In this paper, we propose hierarchical spatial-spectral feature extraction with long short term memory (HSS-LSTM) to explore correlations between spatial features and spectral features and obtain hierarchical intrinsic features for mineral identification. In the proposed model, the fusion spatial-spectral feature is primarily extracted by stacking local spatial features obtained by a convolution neural network (CNN)-based model and spectral information together. To better exploit spatial features and spectral features, an LSTM-based model is proposed to capture correlations and obtain hierarchical features for accurate mineral identification. Specifically, the proposed model shares a uniform objective function, so that all the parameters in the network can be optimized in the meantime. Experimental results on the hyperspectral data collected by the Airborne Visible/Infrared Imaging Spectrometer (AVIRIS) in the Nevada mining area show that HSS-LSTM achieves an overall accuracy of 94.70% and outperforms other commonly used identification methods.
Effect of Contacting Surface on the Performance of Thin-Film Force and Pressure Sensors
Authors: Tang Ka Po Maggie , Yick Kit Lun , Li Pui Ling , Yip Joanne , Or King Hei , Chau Kam Hong
Published: December 2020

Flexible force and pressure sensors are important for assessing the wear comfort of tightly fitting apparel. Their accuracy and repeatability depend on the sensor itself and the contacting surface. Measurements of the contact pressure on soft surfaces like human skin tend to be erroneous, which could be due to incorrect sensor calibrations. This study aims to examine the effects of human body parameters such as the hardness and temperature of the contacting surface by using a custom-made calibration setup and investigating the incorporation of rigid discs on the sensor surface. Two commercial force sensors, FlexiForce and SingleTact, and one pressure sensor, Pliance X, are used in the investigation. The findings reveal that adding rigid discs on both sides of the force sensors improves their sensitivity. Systematic calibration has been performed on the surfaces with different temperatures and hardness. The results show that FlexiForce and Pliance X tend to be affected by the changes in surface temperature and surface hardness. Prolonged testing time shows that the time dependence of SingleTact and Pliance X sensor is lower, which suggests that they are more suitable for lengthier evaluations in which interface pressure is exerted on the human body. In brief, sensor attachment and proper calibration should be thoroughly considered before using sensors for applications on soft surfaces, like the human body.
A Systematic Sensitivity Study on Surface Pixel Shifts in High Spatial Resolution Satellite Images Resulting from Atmospheric Refraction in the Sensor to Surface Ray Path
Authors: Gao Bo-Cai , Ward Evan , Bowles Jeffrey , Yingling Adam
Published: December 2020

When viewing Earth’s surfaces from a low Earth orbiting (LEO) satellite platform with an optical sensor, the upward light propagation path from the ground to the satellite is affected by atmospheric refraction. For imaging sensors with a spatial resolution of about one km on the ground, atmospheric refraction is typically neglected during geo-registration of the satellite images. However, for high spatial resolution imaging systems with surface pixel sizes of approximately one meter or finer, the neglect of atmospheric refraction effects can typically introduce errors of a few meters in the spatially registered images. The atmospheric refraction effects need to be properly taken into consideration during the spatial registration of high spatial resolution satellite images. We have found that, with minor modifications, the ray tracing models implemented inside the LOWTRAN series of atmospheric radiative transfer codes developed in the 1970s and 1980s, in particular LOWTRAN7 in late 1980s, can be used for modeling the pixel displacement resulting from atmospheric refraction for satellite observations. The LOWTRAN series models were originally designed for calculating atmospheric transmittances and radiances for radiation going through long paths of the Earth’s atmosphere. In the ray tracing portions of the codes, a spherical model atmosphere from the ground to 100 km is finely divided into about 30 thin atmospheric layers. The refraction angles for ray paths between consecutive layer boundaries are accurately calculated. We make a new use of the refraction angles calculated by the LOWTRAN7 code to study the surface pixel shift resulting from atmospheric refraction for satellite observations. In this letter, we report the modeling results on surface pixel displacements for different satellite altitudes and downward view zenith angles, several atmospheric temperature and pressure profiles, a few surface elevations, and wavelength dependencies from blue (450 nm) to near-IR (865 nm). These results can have reference values for researchers to estimate refraction-induced pixel displacements in their high spatial resolution satellite images. The results may also potentially help in designing spacecraft algorithms for accurate instrument pointing and mission tasking to automatically capture short-lived science events.
The Use of Fascia Lata Free Graft for Lateral Canthus Reconstruction Following Mohs Lower Lid Surgery
Authors: Nowak Rafal
Published: December 2020

We present a case of a 75-year-old patient who underwent reconstruction of the lower eyelid and lateral canthus following removal of 80% of the lower eyelid due to basal cell carcinoma. A Hughes transconjunctival eyelid-sharing flap was used to form the posterior lamella, and a free skin graft from the ipsilateral upper lid was used to recreate the anterior lamella. The lateral canthal ligament was reconstructed using a free fascia lata graft. A periosteal flap was not used due to local scarring that was the result of previous multiple lateral canthal surgeries. Skin preservation in the lateral canthal area and additional horizontal support for the lower eyelid were achieved by using a local advancement flap. This two-stage surgery produced excellent functional and cosmetic effects. Fascia lata free graft can be an alternative to the periosteal flap for reconstruction of the lateral canthal ligament when use of the lateral orbital periosteum is not feasible.
Suitability Study of Structure-from-Motion for the Digitisation of Architectural (Heritage) Spaces to Apply Divergent Photograph Collection
Authors: Moyano Juan , Nieto-Julián Juan E. , Antón Daniel , Cabrera Elena , Bienvenido-Huertas David , Sánchez Nazareth
Published: December 2020

The digitisation of architectural heritage has experienced a great development of low-cost and high-definition data capture technologies, thus enabling the accurate and effective modelling of complex heritage assets. Accordingly, research has identified the best methods to survey historic buildings, but the suitability of Structure-from-Motion/Multi-view-Stereo (SfM/MVS) for interior square symmetrical architectural spaces is unexplored. In contrast to the traditional SfM surveying for which the camera surrounds the object, the photograph collection approach is divergent in courtyards. This paper evaluates the accuracy of SfM point clouds against Terrestrial Laser Scanning (TLS) for these large architectural spaces with a symmetrical configuration, with the main courtyard of Casa de Pilatos in Seville, Spain, as a case study. Two different SfM surveys were conducted: (1) Without control points, and (2) referenced using a total station. The first survey yielded unacceptable results: A standard deviation of 0.0576 m was achieved in the northwest sector of the case study, mainly because of the difficulty of aligning the SfM and TLS data due to the way they are produced. This value could be admissible depending on the purpose of the photogrammetric model.
Non-Coding RNAs and SARS-Related Coronaviruses
Authors: Henzinger Hanna , Barth Dominik , Klec Christiane , Pichler Martin
Published: December 2020

The emergence of SARS-CoV-2 in 2019 has caused a major health and economic crisis around the globe. Gaining knowledge about its attributes and interactions with human host cells is crucial. Non-coding RNAs (ncRNAs) are involved in the host cells’ innate antiviral immune response. In RNA interference, microRNAs (miRNAs) may bind to complementary sequences of the viral RNA strand, forming an miRNA-induced silencing complex, which destroys the viral RNA, thereby inhibiting viral protein expression. There are several targets for human miRNAs on SARS-CoV-2’s RNA, most of which are in the 5’ and 3’ untranslated regions. Mutations of the viral genome causing the creation or loss of miRNA binding sites may have crucial effects on SARS-CoV-2 pathogenicity. In addition to mediating immunity, the ncRNA landscape of host cells further influences their susceptibility to virus infection, as certain miRNAs are essential in the regulation of cellular receptors that are necessary for virus invasion. Conversely, virus infection also changes the host ncRNA expression patterns, possibly augmenting conditions for viral replication and dissemination. Hence, ncRNAs typically upregulated in SARS-CoV-2 infection could be useful biomarkers for disease progression and severity. Understanding these mechanisms could provide further insight into the pathogenesis and possible treatment options against COVID-19.
Time Series Changes in Fish Assemblages and Habitat Structures Caused by Partial Check Dam Removal
Authors: Nagayama Shigeya , Ishiyama Nobuo , Seno Taro , Kawai Hideyuki , Kawaguchi Yoichi , Nakano Daisuke , Nakamura Futoshi
Published: December 2020

Despite a steep increase in dam removal projects, there are few studies on the biophysical responses to dam removal. In this study, we evaluated the short-term (1.5 years) and long-term (5.5 years) effects of partial check dam removal on fish assemblages and their habitats. First, the habitat preferences of fish were examined at a channel unit scale: pools, rapids, and side channels satisfied the seasonal habitat requirements of the fish assemblages. Partial check dam removal increased the abundance of these habitats and diversified the habitat structures owing to the sediment release from the dam; in contrast, the bedrock distinctly decreased 1.5 years after dam removal. However, 5.5 years after dam removal, the bedrock proportion increased, and the habitat structures were simplified again owing to the re-transportation of sediments. Similar temporal changes were also determined through a reach-scale analysis with a change in the bed materials. Anadromous Oncorhynchus masou began to spawn and recolonize in the upstream section of the dam after the dam removal, causing similar assemblage compositions between the downstream and upstream sections. The abundance of Salvelinus malma and Noemacheilus barbatulus toni in the upstream reaches decreased over time after the dam removal. The temporal changes in the biophysical responses suggest that long-term monitoring is indispensable for the reliable evaluation of dam removal effects.
Temporal Variation of Water Environment Carrying Capacity in a Highly Urbanized Region of China
Authors: Xu Zhiqing , Xiao Shuhu , Du Cong , Deng Qiyu , Yan Bingfei , Zeng Zhiwen , Liu Xueyu
Published: December 2020

China has experienced an unparalleled urbanization process in recent decades, which has dramatically changed the water environment. Quantification of the water environment carrying capacity (WECC) is crucial given its importance to sustainable development. Existing studies have typically focused on the overall WECC system and lacked analysis of its internal features. In this study, the concepts, calculations, and classifications of the WECC were further developed. Using Nanjing, China, as a case study, we developed a hierarchical evaluation indicator system including three system layers (social, environmental and economic subsystems). We applied the entropy weight and fuzzy comprehensive evaluation method to evaluate the temporal variation tendency of WECC, and explored the deep-seated problems stemming from urbanization. The results indicated that WECC in Nanjing was 0.3045–0.5302 during 2006–2017, thus approaching a moderate grade with a relatively slow growth rate. Social, environmental, and economic subsystems increased by 29.3%, 83.1%, and 97.2%, respectively. Overall, Nanjing had a solid foundation regarding its economic subsystem, but its social and environmental subsystems were under pressure. Factors such as slow population growth as well as reduced energy and water use intensity improved WECC, whereas factors such as increased population density and excessive water consumption blocked WECC. Practical suggestions were proposed to resolve the primary problems of the WECC under urbanization. This holistic approach is urgently needed to achieve water environmental sustainability, both for Nanjing and for other emerging cities.
Identification of the Origins of Vadose-Zone Salinity on an Agricultural Site in the Venice Coastland by Ionic Molar Ratio Analysis
Authors: Zancanaro Ester , Teatini Pietro , Scudiero Elia , Morari Francesco
Published: December 2020

Saltwater contamination seriously affects water quality and land productivity of reclaimed farmlands along the Venice Lagoon, Italy. To characterize the hydrogeochemical dynamics involved in this phenomenon, a three-year study was carried out in an experimental field located at the southern margin of the Venice Lagoon. Soil matric potential, quality of soil pore water and groundwater, and soil physical and chemical properties were monitored at five monitoring stations. Relationships between Cl−, Na+, Mg2+, Ca2+, K+, SO42−, Br− ionic concentrations, and electrical conductivity of the water samples with the soil characteristics (e.g., texture, exchangeable cations) were investigated. Soil water flux direction was calculated and related to ion concentrations. Moreover, specific molar ratios (Mg/Ca, Na/Cl, Cl/Br, and SO4/Cl) were calculated to identify the main drivers affecting salinity in the field. The study confirmed that the experimental site was strongly affected by soil and water salinity, and two major contamination dynamics were identified. The first one was mainly driven by seawater intrusion from the near lagoon and salty watercourses, while the second was derived by the interactions between the peaty soil and salts that were originally in place, since the area was only reclaimed a few decades ago. The latter highlighted the potentiality of the experimental field to become an acidic sulfate environment. Ionic ratios were implemented and proved to be an important tool for the identification of salinity origin.
Spatial Heterogeneity Analysis of Short-Duration Extreme Rainfall Events in Megacities in China
Authors: Zhuang Qi , Liu Shuguang , Zhou Zhengzheng
Published: December 2020

Given the fact that researchers require more specific spatial rainfall information for storm flood calculation, hydrological risk assessment, and water budget estimates, there is a growing need to analyze the spatial heterogeneity of rainfall accurately. This paper provides insight into rainfall spatial heterogeneity in urban areas based on statistical analysis methods. An ensemble of short-duration (3-h) extreme rainfall events for four megacities in China are extracted from a high-resolution gridded rainfall dataset (resolution of 30 min in time, 0.1° × 0.1° in space). Under the heterogeneity framework using Moran’s I, LISA (Local Indicators of Spatial Association), and semi-variance, the multi-scale spatial variability of extreme rainfall is identified and assessed in Shanghai (SH), Beijing (BJ), Guangzhou (GZ), and Shenzhen (SZ). The results show that there is a pronounced spatial heterogeneity of short-duration extreme rainfall in the four cities. Heterogeneous characteristics of rainfall within location, range, and directions are closely linked to the different urban growth in four cities. The results also suggest that the spatial distribution of rainfall cannot be neglected in the design storm in urban areas. This paper constitutes a useful contribution to quantifying the degree of spatial heterogeneity and supports an improved understanding of rainfall/flood frequency analysis in megacities.
Hydrodynamic Cross-Scale Archaeology at a Roman River Harbour
Authors: Dempwolff León-Carlos , Lojek Oliver , Selke Valeria , Goseberg Nils , Gerlach Renate
Published: December 2020

Trans-disciplinary research methods and data from archaeology, geology, hydrology, and hydraulic engineering are successfully merged to reevaluate hydrodynamic effects of Roman hydraulic structures at a Rhine river harbour. The archaeological site Colonia Ulpia Traiana, is characterized by its exceptional preservation, providing ample research data on its river harbour. Constructed by the Romans, the berthing area is lined by a wooden quay-wall. Setting this harbour apart is its up-stream tip, which is fitted with a unique hydraulic structure with unknown purpose. Structure related hydrodynamic impacts on the historic Rhine regime are examined by introducing a novel cross-scale multi model approach, consisting of three steps: (i) Scaled physical experiments are performed to investigate the roughness influence of the wooden quay on a local scale. (ii) A numerical representation of the physical experiments is done in Delft3D, validating a linear loss term to accurately capture the roughness influence on the velocity distribution. (iii) A mid-scale Rhine river model of the area is generated that approximates the historic river bathymetry through morphological evolution. The quay-wall is implemented in parametric form and induces a substantial velocity reduction throughout the harbour. The unique structure exhibits hydromechanic properties mimicking present day current-deflection walls, potentially rendering it their primal prototype.
Peranan Material Interior dalam Pengendalian Akustik Auditorium Bandung Creative Hub
Authors: Putra Alnugraha Rachman , Nazhar Ryanty Derwentyana
Published: December 2020

Acoustics in an auditorium interior have a vital role in the continuity of activities in it. Activities in the auditorium are closely related to audio and visual, so designing an auditorium requires an acoustic control system, not only visual elements are considered, but also sound or acoustic control requires special attention. This study describes the role of interior materials in acoustic control in a multifunctional auditorium in the Bandung Creative Hub building, West Java. To determine the quality of the room acoustics under study, the research method used is descriptive analysis by processing data in the form of images, field notes, documentation, and supporting theories according to the principles of interior design science. This study concludes that the interior materials in the multifunctional auditorium in the Bandung Creative Hub Building have met the applicable standards in the acoustic control of the auditorium space. The benefit of this research is that it can be used as a benchmark for auditorium design and can be a reference for space design that requires special acoustic treatment in the future.
Heterobeltiosis and combining ability among Egyptian cotton genotypes under well irrigated and water deficit conditions
Authors: Abdel-Moneam Maamoun A. , Ghoneima Mohammed H. , Abido Waleed A. E. , Hadházy Ágnes , El-Mansy Yaser M. , El-Shazly Mohab W.
Published: December 2020

Two field experiments were carried out during the 2014 and 2015 seasons to evaluate certain genotypes of Egyptian cotton under well irrigated and water stress conditions. The cross combination Giza 69 x Australy recorded the best values for better parent heterosis for all physiological measurements and earliness index under well irrigated and deficit conditions. Of the female parents, Giza 86 was found to be a good general combiner for most yield characters under both normal and stress conditions, followed by Giza 94. Data illustrated that Giza 45 was the best general combiner for most fiber quality traits under both conditions. The cross combinations Giza 86 x Dandra and Giza 69 x Pima S6 showed significant positive SCA values for seed cotton and lint yield/plant under well irrigated and water deficit conditions. However, the combinations Giza 77 x PimaS6 and Giza 94 x 10229 recorded significant positive SCA effects for seed cotton yield/plant under stress. Whilst, the cross Giza 68 x 10229 recorded significant desirable SCA effects for most fiber quality properties. In this context, the estimates significant positive general and specific combining ability effects indicated that the epistasis and/or dominance effects for F1 hybrid in cotton could be important to a certain extent.
Effect of plant growth promoting Rhizobacteria (PGPRS) on yield and quality of processing tomato under water deficiency
Authors: Andryei Bulgan , Horváth Kitti Zsuzsanna , Ráth Szilvia , Nemeskéri Eszter , Neményi András , Pék Zoltán , Helyes Lajos
Published: December 2020

Chlorophyll fluorescence was measured of H1015 tomato hybrid with different bacterial treatments (B0–B1–B2–B3) and three irrigation treatments: regular irrigated (RI), deficit irrigated (DI) and non-irrigated conditions (I0). The aim of the experiments was to show the effects of plant growth promoting rhizobacteria on the yield, dry matter and vitamin C content of processing tomato during different irrigation treatments, and measuring the chlorophyll fluorescence during the ripening and development stages. According to the results, none of the bacterial treatments had a statistical effect on the quantity and quality of the tomato and on the chlorophyll fluorescence, only the irrigation. Further studies are needed.
Comparison of the geranium (Pelargonium) pathological results of 2016-2017
Authors: Vojnich Viktor József , Szarvas Adrienn
Published: December 2020

The research was carried out in a Gyenes Flower gardening between 2016 and 2017 in Kecskemét. The gardening was founded in 1978. Initially, the main plants were gerbera (Gerbera) and yucca (Yucca), later replaced by the geranium (Pelargonium) cultivation as a result of market demand. In horticulture, there are about than 80 variety geranium of the standing, running, semi-trailer types and English gnawing. The Pelargonium had different sizes and colors. The study was set up in 1,000–1,000 pieces of geraniums each year. The following pathogens have damaged the geranium stock: Botrytis cinerea, Pythium debaryanum, with a rare occurrence of Alternaria porri, Phytophthora cryptogea. The greatest destruction was caused by botrytis (Botrytis cinerea). In the first experimental year, 42% of the 1,000 geraniums tested were infected with fungal diseases (30% B. cinerea, 8% P. debaryanum, 4% other fungi). In 2017, fungal infections were detected on 380 geraniums in the 1,000 tested geraniums (290 Botrytis cinerea, 70 Pythium and 20 other fungal diseases). In addition to the use of fungicides, we increased the spatial position of geraniums, early irrigation and frequent ventilation to ensure successful control. By 2017, we were able to reduce the damage caused by pathogens by 4 percent.