bluuebunny/crossref_metadata_2025 huggingface dataset:
Utilização de plantas medicinais por idosos de Lagoa Seca, Paraíba
Authors: Jerônimo Rayane Ellen de Oliveira , Silva Juciely Gomes da , Azevedo Camila Firmino de
Published: April 2020

As plantas medicinais fazem parte da história da humanidade desde os primórdios, possuindo ação terapêutica, curativa e preventiva de inúmeras doenças. Esse conhecimento foi sendo passado entre gerações, sendo os idosos os detentores de maiores conhecimentos e práticas com as plantas medicinais. Porém seu uso inadequado pode representar riscos à saúde, principalmente aos idosos. Portanto, objetivou-se com este estudo realizar uma pesquisa de abordagem etnobotânica com idosos estudantes da Universidade Aberta à Maturidade da Universidade Estadual da Paraíba, no município de Lagoa Seca – PB. A princípio foi realizada uma entrevista com 27 idosos por meio de um questionário semiestruturado, com questões sobre o perfil dos mesmos e o uso das plantas medicinais, em seguida foram realizadas palestras sobre uso de plantas medicinais, formas de cultivo e de preparo. Dos idosos 85,15% eram mulheres e 14,81% homens, com idade variando de 61 a 87 anos. Sobre a forma de uso das plantas medicinais, as mais citadas foram chás (66,66%) e compressa (18,51%). Em relação à eficácia, 92,59% afirmaram que obtiveram bons resultados com o uso das plantas e 7,40% não ficaram satisfeitos com o resultado. A maioria dos idosos estudantes da Universidade Aberta a Maturidade no município de Lagoa Seca – PB, utilizam as plantas medicinais para tratar doenças, estando o alecrim para problemas nos ossos, a camomila para pressão alta e erva doce para insônia. Os mesmos tem grande interesse sobre o uso seguro e racional das plantas medicinais, indicando a importância de ações educativas sobre esse tema.
DETECTION OF MARKERS OF HEPATITIS B AND D VIRUS INFECTION IN BIOLOGICAL MEDIA AND DRIED BLOOD SPOTS
Authors: Isaeva O. V. , Ilchenko L. Yu. , Kichatova V. S. , Potemkin I. A. , Amon E. P. , Saryglar A. A. , Al-Sharabi Shukri A. S. , Kyuregyan K. K. , Mikhailov M. I.
Published: April 2020

The aim of this study was to assess the rates of detection of the major markers of infection with hepatitis B and Delta (D) viruses in serum, saliva and dry blood dots (DBS) as a possible option for serological studies among the population of the endemic region in conditions of limited laboratory resources. For this purpose, paired samples of blood serum and DBS, blood serum and saliva from patients with chronic hepatitis B with Delta agent living in the Republic of Tyva, which is endemic for this disease. HBsAg was detected in 289 (100%) serum samples, in 88/92 (95.7%) saliva samples, in 60/80 (75%) DBS samples, stored three years at room temperature, and in 111/117 (94.9%) DBS stored one year at the same conditions. Anti-HBcore was detected in 209 (100%) serum samples, while in saliva and DBS samples this marker was detected in only 13.04% (12/92) and 19.7% (23/117), respectively. Anti-HDV antibodies in serum were detected in 209 (100%) samples collected from patients in 2017-2018. In saliva and DBS anti-HDV were not detected in any sample. This difference in the detection rates of anti-HBcore and anti-HDV might be accounted for the fact that the HBV core protein is a very strong immunogen, indusing the production of anti-HBcore in high concentrations. Probably, the concentration of anti-HDV is much lower, which explains its absence in saliva and DBS in patients with hepatitis B+D. Samples of biological media (saliva), as well as DBS can serve as an alternative material for the detection of HBsAg in screening and research prevalence studies. Meanwhile, the definition of anti-HDV in such media is not possible due to the false negative results. Due to the high probability of superinfection with HDV in patients with HBV in endemic areas, the detection of HBsAg in alternative media (saliva or DBS) should be followed by testing for anti-HDV in serum samples.
Teknologi Diversifikasi Produk Tahu di Desa Sumbersalak Kelurahan Kranjingan Kecamatan Sumbersari Kabupaten Jember Untuk Meningkatkan Pendapatan Rumah Tangga
Authors: Romadhona Sukron
Published: April 2020

Salah satu Industri Rumah Tangga (IRT) Tahu yang berada di Kabupaten Jember adalah di Desa Sumbersalak, Kelurahan Kranjingan, Kecamatan Sumbersari. Terdapat 2 produsen tahu yang tergabung dalam 1 IRT, dengan rata-rata bahan baku produksi 25 kg/hari untuk tahu dan 20 kg/hari untuk olahan kedelai lainnya, dengan tenaga kerja 4-6 orang. Permasalahan yang dihadapi IRT Tahu ini adalah: (1) Suara dari mesin penggilingan kedelai yang sangat bising, yang berbahaya bagi kesehatan telinga pekerja dan sering mendapat komplain dari warga sekitar, dan (2) Limbah pengolahan tahu yang berbau sering membuat masyarakat merasa tidak nyaman. Solusi untuk mengatasi masalah tersebut adalah dengan: (1) Observasi kegiatan produksi dan diskusi dengan produsen tahu untuk mengetahui permasalahan-permasalahan yang dihadapi dan yang dapat diatasi dan (2) Sosialisasi tentang peluang wirausaha produk olahan tahu dengan ibu-ibu yang berada di sekitar IRT tahu. Adanya pengabdian kepada masyarakat berbasis teknologi tepat guna ini diharapkan dapat: (1) Membantu IRT tahu dalam memperlancar kegiatan produksi, bahkan meningkatkan produksi, sehingga berpeluang untuk meningkatkan kapasitas industri yang pada akhirnya dapat menjadi lapangan pekerjaan bagi masyarakat sekitar, (2) membantu IRT untuk menurunkan polusi akibat aktivitas produksi sehingga tidak mengganggu kesehatan produsen, keluarga dan masyarakat sekitar, dan (3) Membantu masyarakat sekitar dan juga IRT Tahu dengan melakukan wirausaha prodak olahan tahu yang nilai jualnya akan lebih tinggi dan akan lebih besar jangkauan pasarnya.

Kata Kunci: Teknologi Tepat Guna, Pemberdayaan Masyarakat, Limbah Pabrik Tahu
Methods for producing permanent joints of aluminum and titanium alloys
Authors: Nemenenok B. M. , Rafalski I. V. , Lushchik P. E., , Radchenko A. A.
Published: April 2020

Theresultsof the analysis of theoretical and experimental studies of methods for producing permanent joints of dissimilar metals and alloys are presented, as well as the advantages, implementation problems and prospects of using friction stir welding to join titanium and aluminum alloys. It is noted that most studies focus on friction stir welding of light metals such as aluminum, copper, magnesium and their alloys. Despite the great scientific and practical interest, the friction stir welding processes of alloys and metal-matrix composite materials based on aluminum and titanium have been studied less thoroughly and require additional attention.

Giventhevarietyandcomplexityof friction stir welding, the lack of a correct assessment of the reactivity, properties and design features of aluminum and titanium alloys can lead to a number of problems associated with a change in the structure of materials and defects in the welding zone, which is accompanied by the inevitable deterioration of the mechanical characteristics of the finished joints.
Network Analysis, and Experimental Validation to Uncover the Mechanism of the Four Compounds in Artemisia annua (Qing Hao) Antimalarial
Authors: zhao yuping , Zhang Xiaobo , Xu Haiyu , Wang Ling , Huang Luqi
Published: April 2020

Background: Artemisinin is widely used to anti malaria, but the antimalaria mechanism and coordinative interaction of Artemisinin, Scopoletin, Arteannuin B and Artemisic acid are not clear. Methods: Based on the existing of antimalarial drugs, the antimalaria targets of Artemisinin, Scopoletin, Arteannuin B and Artemisic acid were explored by molecular docking with the similarity theory of chemical structure, and then the the antimalaria mechanism of Scopoletin and its coordinative antimalaria interaction of the mixture with the three other ingredients. Results: Then through using the text information excavation's method, the relevance proteins of antimalaria effect of Artemisinin were IL-6, ACHE, PC3, IPOB, CYC, TNF-α, UGT1A9, CASP3, XDH, IL-1β, VEGF, CAT, CREB, AMPK, UGT1A6, ADR, MAPK, COX2, LB24AB and CYP450. Meanwhile, the relevance proteins of Scopoletin were TNF-α, PI3K, IL-8, IL- 6, VEGF, IL-1β, MAPK, CD4, SP2, CTNNB, CASP3, PRO1400, IgE, IL-4, ICAM1, p38, STAT3, TLR4 and API4. But Arteannuin B and Artemisic acid had a little relevance with the above proteins. The interaction characteristic between TNF-a and Artemisia annua was the effect of the mixture of Artemisinin, Scopoletin, Arteannuin B and Artemisic acid was greater than Artemisinin, and the synergistic effect of the four elements was found in the progress of antimalaria. Conclusion: Antimalarial target of Artemisia annua ingredients was explored with data mining methods, and the antimalarial effect of Scopoletin may be related to TNF. Combined application of the four elements could achieve the same antimalarial effect and reduce the clinical usage of Artemisinin and Scopoletin.
Optic Perineuritis and its Association with Rheumatic Connective Tissue Disease
Authors: Li Hongyang , Zhou Hang , Sun Jiao , Wang Huihui , Wang Yanling , Wang Zhenchang , Li Jing
Published: April 2020

Objective Analyze the etiology and clinical characteristics of optic perineuritis (OPN) in a Chinese patient population Methods Neuro-ophthalmological examination and a series of blood samples were used in this retrospective observational cohort study to compare characteristics of OPN with idiopathic demyelination optic neuritis (IDON). Results 44 OPN cases (74 eyes) and 61 IDON cases (78 eyes) were analyzed. The causes of OPN with CTD were Graves’ disease, Immunoglobulin G4-related disease (IgG-4 RD), granulomatosis with polyangiitis (GAP), systemic lupus erythematosus (SLE), Sarcoidosis, Rheumatoid, scleroderma, Behcet's disease, and gout. Overall, 33 cases showed orbit fat infiltration. Specifically, 9 cases with IgG-4 RD showed trigeminal nerve branch involvement, 12 cases with Graves’ showed extraocular muscle belly enlargement, and 4 cases with GAP showed pterygopalatine fossa pseudotumor through orbital magnetic resonance imaging (MRI). Compared to IDON patients, OPN patients were older (p=0.004) and more likely bilateral involvement 26 (78.79%) patients had bilateral involvement in OPN group versus 17 (27.87%) in the IDON group (p<0.001). Visual acuity scores was better in OPN patients compared to those with IDON, 0.55±0.91versus 1.19±1.24 (p<0.001). 8 (13.11%) IDON patients also had multiple sclerosis (MS) and 7(11.48%) patients had neuromyelitis which was significantly more than the 0 patients in OPN group (p=0.04). Conclusions OPN had distinct etiologies and clinical characteristics from IDON and is more often associated with rheumatic CTD. Using OPN characteristics to diagnose CTD should prove useful for clinicians when presented with patients that have multiorgan dysfunction that include ophthalmologic findings.
Gender differences in 10746 open carpal tunnel releases – a national registry-based cohort study
Authors: Brogren Elisabeth Linda , Zimmerman Malin
Published: April 2020

Background Carpal tunnel syndrome (CTS) is more common in women than in men. We aimed to investigate gender differences in perceived symptoms and disability before and after open carpal tunnel release (OCTR).Methods All (n=10746) OCTR’s in the Swedish National Quality Register for Hand Surgery (HAKIR) between 2010 and 2016 were included. Outcome was assessed with QuickDASH (short form of Disabilities of Arm, Shoulder and Hand) and 8 symptom-specific questions at baseline and 3 and 12 months postoperatively.Results There were 67% (7150/10746) women with a mean age of 55± SD 17 years (men 59±15 years). Preoperatively, women scored higher than men in QuickDASH (mean 54±21 vs. 44±21; p<0.0001). Postoperatively, higher QuickDASH scores were found in women >45 years of age compared to their male counterparts. Pain on load and weakness were scored higher by women than by men at all three time points. In the linear regression analysis, QuickDASH scores were higher among women; 10.2 points (95% CI 8.8-11.6; p<0.0001) preoperative, 6.4 (4.6-8.1; p<0.0001) at 3 months postoperative and 5.7 (3.5-7.9; p<0.0001) at 12 months postoperative, adjusted for age at surgery and diabetes. These differences disappeared when also adjusting for preoperative QuickDASH scores.Conclusion Women with CTS treated with OCTR rate their disability and symptoms higher than men before surgery, and these differences persist in women above 45 years after surgery, indicating more residual symptoms. Gender differences should be considered when evaluating patients with CTS.
FXR expression in a rat model of hilar cholangiocarcinoma
Authors: Zhang Meng-yu , Wang Jie-ping , he Kai , Xia Xian-ming
Published: April 2020

AIM: To develop a rat model of hilar cholangiocarcinoma and detect Farnesyl X receptor (FXR) expression in hilar cholangiocarcinoma tissues of this model, in order to provide a new method for the treatment of hilar cholangiocarcinoma. METHODS: Forty male Wistar rats (body weight, 185 ± 5 g) were randomly divided into two groups (n = 20 each) as follows: The control group was fed a standard diet, and the experimental group was injected by cholangiocarcinoma QBC939 cell suspension along the hilar bile duct into the bile duct bifurcation with microsyringe. Every day note the rats’ mental state, diet, and fur condition. At 4 weeks, one rat of the experimental group was sacrificed after it was administered anesthesia, and we recorded changes in hilar bile duct size, texture, and form. This procedure was repeated at 6 weeks. After 6 weeks, , hilar cholangiocarcinoma developed only in the experimental group, thereby establishing an experimental model for studying QBC939-induced hilar cholangiocarcinoma. Tumor formation was confirmed by pathological examination, and hilar bile duct tissues were harvested from both the groups. A real-time polymerase chain reaction assay and an immunohistochemical assay were used to analyze the expression of FXR in hilar cholangiocarcinoma and normal hilar bile duct tissues. RESULTS: From the second week, the rats in experimental group began to eat less, and their body mass decreased compared with controls. After 6 weeks, we detected hilar cholangiocarcinoma in 17 rats (85%) in the experimental group. In the experimental group with hilar cholangiocarcinoma, we found that the levels of total cholesterol, total bilirubin, and direct bilirubin were higher compared with those of the control group. Simultaneously, muddy stones emerged from the bile ducts of rats in the experimental group. The FXR /Gapdh mRNA ratio in hilar cholangiocarcinoma and normal hilar bile duct tissues differed markedly (16 and 35, respectively). Light microscopy revealed a granular pattern of FXR expression which reacted with the anti- FXR antibody. Each section was randomly divided into six regions, with 80 cells were observed in every region. Sections with >10% positive cells were designated positive, Sections with <10% positive cells were designated negative. Each group included 4,800 cells. In the experimental group, 1,196 cells (24.9%) were positive and 3,538 cells (73.7%) were positive in the control group, and this difference was statistically significant (χ2 = 10.35, P < 0.05). CONCLUSION: FXR expression significantly decreased in hilar cholangiocarcinoma of rats than in those of controls, suggesting that drugs targeting FXR may be a new strategy for hilar cholangiocarcinoma.
Fault diagnosis of shield machine based on RFE and ELM
Authors: Liu Xuanyu , Qi Wenbo , Wang Yudong , Shao Cheng , Cong Qiumei
Published: April 2020

Shield machine is a complex large-scale tunneling equipment with multiple systems and driving sources. In order to improve the accuracy and efficiency of fault diagnosis for shield machine, a method based on the combination of reverse feature elimination (RFE) and extreme learning machine (ELM) is proposed. For the characteristics of shield machine operation data with many dimensions and large quantity, the RFE method is introduced to reduce the dimension of data, eliminate the redundant dimension and remove the correlation between features. Considering the neural network has the slow speed and low efficiency of fault diagnosis, the ELM neural network classifier model is built based on the extremely learning mechanism for fault diagnosis of shield machine. The simulation results based on the field construction data show that this method improves the accuracy and efficiency of fault diagnosis of shield machine significantly and has good engineering application value.
Clinical characteristics of survivors and non-survivors, medical and non-medical staff members with 2019-nCoV pneumonia in Wuhan, China: a descriptive study
Authors: Hu Jiaxun , Lv You , Xu Ying , Miao Yushan , Wang Wei , Le Wenqing , Tang Hao
Published: April 2020

Objectives: In December 2019，the 2019 novel coronavirus ( 2019-nCoV ) emerged in Wuhan, China, leading to a cluster of severe pneumonia cases. Medical staff members on the front line were also infected. We compared the epidemiology, clinical characteristics, and treatment measures of survivors and non-survivors and the different clinical outcomes of medical staff members and non-medical members of the community infected with 2019-nCoV. Methods: We included 81 patients with adult 2019-nCoV in Hankou Hospital from mid-January to mid-February 2020 in this single-center retrospective study. Data were compared between survivors and non-survivors and between medical staff members and non-medical individuals. Results: All 38 medical staff members were infected by patients while working. Only 2 (2.5%) non-medical individuals had a clear history of exposure to 2019-nCoV patients. The median age was 49 years (interquartile range [IQR], 35-59; range, 23-89 years), and 42 (51.9%) were women. We found that the median age,comorbidity, and some laboratory outcomes(lymphocyte count, urea nitrogen, aspartate aminotransferase, lactate dehydrogenase, etc.)differed significantly between survivors and non-survivors. There were also significant differences in the time from onset to admission, disease classification, comorbidity, and prognosis between medical staff members and non-medical individuals. All medical staff members were cured, while 13 (30.2%) non-medical individuals died. Conclusions: Older males with comorbidities are more likely to be affected by 2019-nCoV. Significant changes in some laboratory markers may indicate a poor prognosis. Medical staff members may have had better prognoses due to fewer comorbidities and better medical compliance. Key words: 2019-nCoV; Clinical characteristics; Mortality; comorbidity; Survivors; Non-survivors; Medical Staff
WITHDRAWN: Elucidation of the active compounds and molecular mechanisms of Smilacis Chinae Rhizoma for treatment of pelvic inflammatory disease based on network pharmacology and MMGBSA-docking
Authors: Zhang Yunsen , Zhao Zikuang , Wang Wenxiang , Li Qi , Chen Huimin , Li Xuanhao , Fan Gang , Zhang Yi
Published: April 2020

Background Smilacis Chinae Rhizoma (SCR) is widely used in the treatment of pelvic inflammatory disease (PID). However, its active ingredients and the mechanisms against PID remain elusive. This study aimed to clarify the active ingredients and explore their molecular mechanisms on PID. Method Network pharmacology and MMGBSA-docking exploited the active compounds and mechanisms against PID, as well as validating the binding mode of candidate targets.Results Network pharmacology revealed 32 active compounds and 718 compound-related targets mapped to 91 pathways which were clustered 7 genres (e.g., immunoregulation). C-T-P network and PPI analysis illustrated 17 PID-related targets, indicating that SCR may decrease inflammation, ameliorate fibrosis, and inhibit microorganisms via bidirectionally regulating IL-17 signaling pathway. Furthermore, active compounds were uncovered that bound to prostaglandin-endoperoxide synthase 2, matrix metalloprotein-9, lipocalin, signal transducer and activator of transcription 3, myeloperoxidase, and tumor necrosis factor. 19 active compounds (e.g., rutin (-66.43 kcal/mol), moracin M (-37.01 kcal/mol) and oxyresveratrol (-38.84 kcal/mol)) were found to show excellent binding free energy, demonstrating that H-bond, Pi electron cloud and electrostatic potential as the main binding ability to these targets. Conclusion Approach of network pharmacology and MMGBSA-docking revealed the active ingredients, such as rutin, moracin M, and oxyresveratrol, in SCR and dissected it exhibits the therapeutic eﬀects (e.g., decrease inflammation, ameliorate fibrosis, and inhibit microorganisms) of PID by the bidirectional regulation of IL-17 signaling pathway.
Aortic calcification in patients with rheumatoid arthritis and ankylosing spondylitis: a cross-sectional case-control study
Authors: Zhao Xuan , Wang Qian , Luo Yuanyuan , Liu Yingshuang , Gao Song , Cong Wenbin , Li Hua , Li Hui , Sun Mingshu
Published: April 2020

Objectives: Vascular calcification contributes to cardiovascular consequences in rheumatoid arthritis (RA) and ankylosing spondilytis (AS). This study was to evaluate the aortic calcification in RA and AS, and investigate possible risk factors. Methods: The in-patients with RA or AS were consecutively recruited from a general hospital. Control subjects were healthy population recruited from the same hospital. The aortic calcification score (ACS) was obtained by 256-slice spiral CT scanners using the Heart Beat-CS program (Philips Medical Systems, Cleveland Ohio, USA). Results: 146 RA patients, 97 AS patients and 200 controls were included. Serum triglyceride, cholesterol, urate, high and low density liptein cholesterols in RA or AS were all lower than that in controls. The ACS was higher in RA group than in AS and control groups. Only young (≤50 yrs) female AS had ACS higher than controls. Compared with the controls, RA increased the risk for aortic calcification by 4.72 (95% CI 2.78-7.99) fold after adjusted for age and sex. While AS in general, did not. Advanced age, male sex and elevated blood glucose were the risk factors for ACS in controls; advanced age, high C-reactive protein (CRP) and more co-morbidities were the risk factors in AS; and advanced age, long disease course, high DAS28(CRP) were risk factors in RA. Conclusions: Patients with RA or AS were more likely to develop aortic calcification compared with age and sex-matched healthy controls. Long disease course and high inflammatory criteria were risk factors, which advocate an intense control of disease associated systemic inflammation.
The investigation of relation between Anxiety and Syndrome Metabolic profiles after 12 Months Aerobic Exercise whit Moderate Intensity in 50-65 Years Old Women with Syndrome Metabolic
Authors: Osali Ali
Published: April 2020

Background and purpose The aim of this research was to investigate the effect of twelve Month aerobic exercise whit moderate intensity on anxiety in 50-65 years old women with syndrome metabolic and relation between anxiety and Syndrome Metabolic profiles.Materials and methods 24 women with syndrome Metabolic participated voluntarily in this investigation and divided in two-group MetS exercise (ME), MetS control (MC). ME group participated in an aerobic exercise training (AT) program (12 Month), three session per week, each session contained three performing parts and two rest part. Also, Beck anxiety questionnaire and blood samples were conducted before and after training for evaluating levels of anxiety. Data were analyzed using Pried-sample T-Test, Independent samples T-Test, and Pearson correlation. Results anxiety after 12-month aerobic exercise significantly decreased (P˂0.05), and there was a significant relation between improvement of syndrome metabolic and decreasing of anexiety.Conclusion These findings indicate that 12-month aerobic exercises induce to decrease anxiety and ameliorate syndrome metabolic. Moreover, we can say ameliorating in Syndrome Metabolic profiles maybe related to decreasing in anxiety levels.
Health Technology Assessment of Ultraviolate light based imaging technology to reduce burden of hospital acquired infections: A Study Protocol
Authors: Shah Komal , Kotwani Priya , Saha Somen
Published: April 2020

Background: HAIs impart a huge clinical and economic burden in India. Healthcare worker’s compliance to hand hygiene protocol can play an important role in preventing the transmission of cross-infection and thus reducing the HAIs. Over last few years, there has been a wide use of ultraviolate (UV) based fluorescent markers for assessing quality of hand hygiene. This Health Technology Assessment (HTA) study will be conducted with the aim to identify low cost, easy and feasible strategy having potential to get integrated in the current health system to deal with issue of HAI in ICU settings.Methods: The study will be conducted in three phases. The impact of innovation on hand hygiene compliance will be assessed quantitatively by undertaking meta-analysis of secondary literature on UV based imaging tool in improving hand hygiene compliance in ICUs. Following this, the feasibility of using this innovation in developing country like India will be assessed. Decision Analytic modelling will be conducted for cost-effectiveness analysis using health systems perspective. Cost per ICU stay (day) and QALY gained will be calculated and ICER will be reported to comment on the cost-effectiveness of the innovation.Discussion: The HTA study will provide a comprehensive overview of the effectiveness of UV light based imaging device in reduction of HAIs. The results of this HTA study will generate evidence for the decision makers for its incorporation in public healthcare system of India.Systematic review registration: The protocol has been registered in Prospero (Prospero Id: CRD42018108960)
Синтез наночастиц палладия на поверхности оксида церия(IV) под воздействием ультрафиолетового излучения и их диагностика
Authors: Киричков М. В. , Поляков В. А. , Терещенко А. А. , Шаповалов В. В. , Гуда А. А. , Солдатов А. В.
Published: April 2020

Проведен синтез наночастиц палладия с использованием комплексного оксалата палладия в качестве прекурсора в водной среде методом УФ-облучения. Образцы исследованы различными лабораторными методиками, такими как просвечивающая электронная микроскопия, рентгенофлуоресцентный анализ, рентгеновская порошковая дифракция, XAFS-спектроскопия и ИКспектроскопия диффузного отражения с использованием зондирующих молекул CO. Микроизображения, полученные с помощью просвечивающей электронной микроскопии, не позволили отличить наночастицы Pd от материала подложки, но показали отсутствие влияния УФ-излучения на размеры наночастиц CeO2. Данные рентгенофлуоресцентного анализа показали наличие в материале атомов церия и палладия. Дифрактограммы свидетельствуют о присутствии фаз диоксида церия и металлического палладия, также анализ спектров XAFS за K-краем палладия показал наличие в системе фазы PdO. Приблизительный размер наночастиц палладия оценен по ИК-спектрам после адсорбции CO, он составил не более 2 нм, что существенно меньше среднего размера наночастиц Pd, полученных аналогичным способом без подложки CeO2(1.5–9.5 нм).
Okul Yöneticilerinin Eğitimde Değişime İlişkin Görüşleri
Authors: KURU ÇETİN Saadet , NAYIR Funda , TAŞKIN Pelin
Published: April 2020

Son yıllarda özellikle teknoloji alanındaki değişimin hızı şaşırtıcı bir şekilde artmaktadır. Teknolojik değişimlerin ortaya çıkardığı toplumsal yapı, eğitim alanını da etkilemekte, okulların, öğretmenlerin ve okul yöneticilerinin rolleri yeniden incelenen bir konu haline gelmektedir. Bu araştırmanın amacı, eğitim örgütlerinin değişimlere ayak uydurmaları çerçevesinde okul yöneticilerinin bu teknolojik yeniliklerden ya da değişimlerden haberdar olma durumlarını ortaya koymaktır. Araştırmanın çalışma grubunu resmi okullarda görev yapan ve araştırmaya katılmaya gönüllü 32 okul yöneticisi, okul müdürü ve müdür yardımcılarından oluşmaktadır. Araştırmanın sonuçlarına göre, okul yöneticilerinin tarihsel süreç içerisindeki değişimlere ve endüstri kavramları olan endüstri 1.0, 2.0, 3.0 ve 4.0 ve toplum 5.0 kavramlarına ilişkin bilgi sahibi olmadıkları, araştırmaya katılan okul yöneticilerinin çoğunun okullarında teknoloji temelli sınıfların olmadığı ortaya çıkmıştır. Araştırmada ortaya çıkan bir başka sonuç ise okul yöneticilerinin bir kısmının teknolojiyi eğitimin tamamlayıcı bir öğesi olarak görmeleri, bir kısmının da teknolojinin eğitimi olumsuz yönde etkileyeceğini düşünmeleridir. Araştırma bulgularında son olarak okul yöneticilerinin öğretmenlerin teknolojiyi takip etmede öğrencilerden geri kaldığını düşündüğü görülmektedir.
Тепловые, магнитные и магнитотранспортные свойства быстрозакаленнго ленточного образца Ni-=SUB=-50-=/SUB=-Mn-=SUB=-35-=/SUB=-Al-=SUB=-2-=/SUB=-Sn-=SUB=-13-=/SUB=-
Authors: Хизриев Ш.К. , Гамзатов А.Г. , Батдалов А.Б. , Алиев А.М. , Ханов Л.Н. , Kim D.-H. , Yu S.-C. , Yen N.H. , Dan N.H.
Published: April 2020

The heat capacity, thermal diffusivity, thermal conductivity, magnetization, and electrical resistance in a tape sample of Ni50Mn35Al2Sn13 alloy were studied. The temperature dependence of thermal diffusion shows pronounced anomalies in the form of minima associated with magnetic and magnetostructural transformations. The behavior of thermal conductivity and thermal diffusion indicates that the mean free path of heat carriers is limited by the structural imperfections of the tape. The transition of the sample to the martensitic phase is accompanied by a sharp increase in the electrical resistance, suggesting an increase in the electron relaxation rate due to structural distortions inherent in martensite. The magnitude of the magnetoresistive effect ∆ρ/ρ_0 in the field of 1.8T near the martensitic transition is reached 40%. The temperature hysteresis was revealed in the dependence ρ(T) near TC, which indicates the structural heterogeneity of the austenitic phase.
Изменения диэлектрических и механических свойств сферопластика, содержащего металлизированные стеклянные микросферы, вызванные деформацией сжатия
Authors: Садовничий Д.Н. , Милехин Ю.М. , Малинин С.А. , Вихорнова Т.Л. , Осавчук А.Н. , Мельников В.П. , Шереметьев К.Ю. , Перцев Н.В.
Published: April 2020

Представлены экспериментальные результаты изменений диэлектрических и механических характеристик сферопластика на основе кремнийорганического эластомера и металлизированных стеклянных микросфер, вызванных статическим и ударным сжатием. Установлено наличие двух областей частотной дисперсии диэлектрической проницаемости, связанных с наличием металлического покрытия микросфер. Обнаружено, что при относительной деформации сжатия не менее 70% наблюдается резкое снижение как низкочастотной, так и высокочастотной дисперсии комплексной диэлектрической проницаемости. Обсуждены возможные причины обнаруженного изменения комплексной диэлектрической проницаемости. Ключевые слова: сферопластик, микросферы, диэлектрические характеристики, механические характеристики.
Исследование формирования слоев станната цинка методом рентгеновской фотоэлектронной спектроскопии
Authors: Налимова С.С. , Шомахов З.В. , Мошников В.А. , Бобков А.А. , Рябко А.А. , Калажоков З.Х.
Published: April 2020

The features of the formation of zinc stannate nanostructures are considered that are of interest for gas sensors, solar energy and conducting transparent electronics. The samples were obtained by hydrothermal method using zinc oxide nanorods as a template with the variation of synthesis time and investigated by X-ray photoelectron spectroscopy. It is shown that this method can be used to analyze the formation of zinc stannate.
Влияние режимов измельчения порошковых материалов (Sm,Ho)-=SUB=-2-=/SUB=-Fe-=SUB=-17-=/SUB=-N-=SUB=-x-=/SUB=- (x=0; 2.4) на их структуру и магнитные свойства
Authors: Веселова С.В. , Терёшина И.С. , Вербецкий В.Н. , Карпенков А.Ю. , Савченко А.Г.
Published: April 2020

The composition, structure, topology of the surface of a cast, homogenized, and nitrogenated alloy based on the Sm2Fe17 intermetallic compound by Ho substitution for Sm have been investigated by means of X-ray fluorescence, X-ray diffraction, and scanning electron microscopy using BSE/EDS detectors. Magnetic properties are presented for initial Sm1.2Но0.8Fe17 compound, Sm1.2Но0.8Fe17N2.4 nitride and its milled powders. It has been established that the partial substitution of Sm by Ho in the rare-earth sublattice in combination with the effect of introduction of nitrogen into the lattice of initial compound lead to an increase of such magnetic characteristics as specific magnetization and coercive force. Comparative analysis of the magnetic hysteresis properties of powder samples showed that an increase of the milling time Sm-Ho-Fe-N powders using high-energy ball milling (15, 30, 45 and 60 min) improves the main magnetic characteristics. The functional characteristics of Sm-Ho-Fe-N powders prepared by milling are an important for the development of new high-coercive permanent magnets based on them.
Синтез гетерогенных наноструктур ZnO/Co-=SUB=-3-=/SUB=-O-=SUB=-4-=/SUB=- методом химического осаждения из растворов
Authors: Абдуллин Х.А. , Жумагулов С.К. , Исмаилова Г.А. , Калкозова Ж.К. , Кудряшов В.В. , Серикканов А.С.
Published: April 2020

Nanocrystalline cobalt oxide Co3O4 and the ZnO / Co3O4 composite were obtained by the chemical bath deposition method followed by thermal annealing. It has been shown that the growth mechanism of cobalt carbonates changes dramatically in the presence of zinc oxide particles during synthesis, as a result, the phase composition, morphology, and material properties change. The conductive layers formed from the ZnO / Co3O4 composite have an electrical resistance at room temperature that is more than three orders of magnitude lower than the resistance of the Co3O4 layers, and ZnO / Co3O4 composite gas sensors showed significantly higher gas sensitivity at room temperature than that of control cobalt oxide sensors.
ASSOCIATION BETWEEN MATRIX METALLOPROTEINASE-1 −1607 1G/2G POLYMORPHISM AND CHRONIC PERIODONTITIS IN INDONESIAN POPULATION
Authors: HAYATI RAHMATUL , SUHARTONO ANTONIUS WINOTO , MASULILI SRI LELYATI , TALBOT CHRISTOPHER , AUERKARI ELZA IBRAHIM
Published: April 2020

Objective: This study aimed to identify the distribution of matrix metalloproteinase (MMP)-1 −1607 1G/2G alleles and genotypes in subjects withchronic periodontitis and healthy subjects in a sample of Indonesian population and assess the possible association of this polymorphism withsusceptibility to chronic periodontitis.Methods: Genomic DNA samples were obtained from 200 Indonesian males aged 33–78 years old, comprising 100 chronic periodontitis patientsand 100 healthy controls. DNA fragments were amplified by a polymerase chain reaction and analyzed by restriction fragment length polymorphism.Results were analyzed by Chi-square test.Results: The frequency of the 2G allele was high both in subjects with periodontitis (87%) and in controls (91%). Analysis of MMP-1 genotype(−1607 1G/2G) showed no significant difference between the chronic periodontitis and healthy groups (p>0.05).Conclusion: The result found no association between MMP-1 −1607 1G/2G polymorphism and susceptibility to chronic periodontitis in Indonesiansubjects.
IMPLEMENTATION OF TOTAL QUALITY MANAGEMENT (TQM) IN RAISING THE QUALITY OF EDUCATION IN PRIVATE MADRASAH TSANAWIYAH
Authors: SETIAWAN Ahmad
Published: April 2020

This research in purposes is to implement the Total Quality Management (TQM) to raise the Quality of education in private Madarasah Tsanawiyah (MTs. Muhammadiyah Bandung. The research method used is qualitative method. The sampling technique is purposive sampling. Data will use primer data, which taken directly from the respondent and secondary data which become supporting data. Based on the research result, the Implemetation of Total Quality Mangement of privat Madrasah Tsanawiyah is very good. By good steps and commitment effort and also focus in realizing the vision, mission, and purposes of the school applying school’s program strategicly and continuously.Explorating the potential of human and natural resources and developing relationship with harmony between schools and the stakeholders and also processing creativity and innovation program of the school. Every obstacle and innovation became the first step to motivate the school to optimize the potentials so we can act that every weak and obstacle is never exist.
Narrative Exchange as Knowledge Transfer: The Rhetorical Construction of Opposition to GM Crops in SW England
Authors: Downing David
Published: April 2020

The release of genetically modified organisms into the environment and food chain in the UK has produced one of the most visible and enduring controversies of recent times. Amid ongoing claim and counter-claim by actors on either side of the GM ‘debate’ over the salient ‘facts’ or balance of risks and benefits associated with the technology, this controversy can be fruitfully seen as a struggle between contested networks of knowledge. Drawing on ethnographic data collected during recent PhD fieldwork, I focus on those, loosely defined as members of ‘local food networks’ in SW England, who perceive their values and cultural projects to be at risk from the deployment of this technology. In scrutinizing how distinctly ‘oppositional’ knowledge is created, exchanged and transformed particularly in relation to the construction and maintenance of cultural and historical boundaries, I suggest that in this arena a key vehicle of knowledge transfer is the narrative or story. A successfully deployed narrative can resolve uncertainties, or equally, dissolve undesirable certainties. Knowledge transfer thus becomes a matter of rhetoric, of persuasion, whereby skilfully deployed narratives can be viewed as analogical networks of associations - enrolling culturally appropriate characters, values and concepts - to move the targeted audience in the desired manner. I argue that such transfers must be seen not only as exchanges of networks of knowledge but also of networks of ignorance, for as the ethnographic data reveals, when the stakes are perceived to be so high, ideological coherence often outweighs empirical evidence and logical consistency. This raises a critical dilemma for the ethnographer. What should he/she do when confronted in the field by exaggerated claims or misinformation?
Three narratives of anthropological engagement
Authors: Calestani Melania , Kyriakakis Ioannis , Tassi Nico
Published: April 2020

This article is an account of different experiences, reflections and impressions that have arisen when embarking on the process of doing anthropological research and writing a thesis. The common ground of these three narratives is that they refer to our personal engagement with anthropology, our experiences within the academic world, as well as to our restless endeavour to make sense of them. We are particularly concerned with the language, the methods, and what usually remains unsaid or is taken for granted with regard to the context of anthropological training, fieldwork and writing up. Our claim is that whereas we as anthropologists attentively take into account the context of our research, we have often failed to pay a similar kind of attention to ourselves and our academic context. We see this article as a contribution towards such study.
Idosos, aplicativos e smartphone: uma revisão integrativa.
Authors: Sales Márcia Barros de , Souza Juliana Jesus de , Sales André Barros de
Published: April 2020

RESUMO: Este artigo pretende analisar pesquisas já consolidadas, de âmbito nacional e internacional, sobre as Tecnologias da Informação e Comunicação (TICs), disponibilizadas em smartphones direcionadas para usuários idosos. A metodologia usa revisão integrativa com publicações compreendidas entre 2009 e 2018, em base de dados indexadas como: SCOPUS, Journal Citation Reports (JCR), Association for Computing Machinery (ACM) e Google Scholar, da área de informática relacionadas a área de Interface Humano-Computador. Entre os resultados destacam-se: a análise e sistematização de 23 estudos e a sua categorização em: a) estudos desenvolvidos para benefício da saúde do idoso; e b) pesquisas sobre a avaliação de usabilidade de smartphones e aplicativos para o usuário idoso, conforme o contexto em que foram analisados, desenvolvidos ou avaliados.
Eu, centenário, vaqueiro do sertão - Histórias sobre a verdade de envelhecer
Authors: Cerqueira Monique Borba
Published: April 2020

Revela-se, a seguir, a narrativa de vida de um vaqueiro centenário, a partir de entrevistas realizadas em Tracupá, sertão nordestino — Bahia, Brasil. Trata-se de dar visibilidade às formas de apropriação da realidade investidas por Seu Rael, 101 anos, com ênfase no seu trabalho, lazer, memória e cotidiano. Ao final, a simples e extraordinária história de vida desse vaqueiro é colocada em paralelo com as dificuldades do quadro de saberes e poderes sobre o envelhecimento contemporâneo, que insiste em não tratar o envelhecer como coroamento do viver.
Avaliação cognitiva e da independência funcional de idosos em instituição de longa permanência em Araraquara, SP, Brasil.
Authors: Toninatto Beatriz Cristina , Nunciato Ana Claudia
Published: April 2020

O objetivo foi avaliar a função cognitiva e a independência funcional de indivíduos residentes em uma instituição de longa permanência (ILP) na cidade de Araraquara, estado de São Paulo, Brasil. Foi realizada a avaliação clínica composta por Mini-Exame do Estado Mental (p= 0,7413), Teste do Relógio (p= 0,7407) e Medida de Independência Funcional (p= 0,8834). Não foi encontrada diferença da função cognitiva e da independência funcional em indivíduos residentes em ILP.
La formación de extensionistas en prácticas de lectura y escritura con niños y adolescentes en contextos de vulnerabilidad
Authors: Marder Sandra Esther , Denegri Adriana , Soto Fernando Ariel , Lo Gioco Carla , Dopazo Emanuel
Published: April 2020

Este escrito presenta el trabajo de articulación entre dos proyectos de Extensión acreditados por la Secretaria de Extensión Universitaria de la UNLP: “Niños/as, Adolescentes y Derechos” de la ONG Recrearte y “Desarrollo integral infantil y aprendizaje en territorio”. Ambos atienden a niños y adolescentes en edad escolar que viven en barrios en situación de pobreza de City Bell. El foco del trabajo está puesto en el ejercicio del derecho a la educación con eje en la alfabetización que se lleva adelante a través de un programa de intervención en lectura junto con otras actividades de índole artístico y/o recreativo. Se debate sobre diferentes concepciones de la extensión universitaria, el “fracaso” en la escolaridad de los sujetos, la perspectiva de derechos y el concepto de infancias y, se finaliza con tres crónicas que intentan ilustrar la necesidad de trabajo en terreno que requiere la formación de los psicólogos/as en la Facultad.
The Strategic Role Of the Local Communities in The Development Of Cross-Border Cooperation Between Ukraine And The EU (on the example of the Transcarpathian Region)
Authors: Melehanych Hanna Ihorivna
Published: April 2020

This article is devoted to the study of the implementation of cross-border cooperation between Ukraine and EU countries. Transcarpathia was chosen as the region for the study because it is here that Ukraine is bordering with four European states. The most important role in the implementation of cross-border programs belongs to the communities in the field provided by the local self-government bodies. It is they who have the relevant knowledge and experience to successfully implement projects and programs from different funding sources targeted for the development of cross-border regions. The successful development and success of Ukraine’s border territories largely depend on the successful mobilization and strategic use of funds.
The efficacy of the combination of eribulin and trastuzumab in advanced HER2-positive breast cancer: the results of Russian observational study
Authors: Kovalenko Elena I. , Artamonova Elena V. , Karabina Elena V. , Andreiashkina Irina I. , Prokof’eva Ekaterina A. , Popova Nataliia O. , Gaisina Elena A. , Evstigneeva Irina V. , Shaidorov Mikhail V. , Zhiliaeva Larisa A. , Ponomarenko Dmitrii M. , Khasanova Alfiia I. , Mukhametshina Guzel Z. , Koziakov Anton E. , Vorotilina Liudmila V. , Povyshev Anton Iu. , Simolina Elena I. , Marfutov Vasilii V. , Kozlov Dmitrii V. , Suslova Irina R. , Shikina Valentina E. , Karandeeva Tatiana V. , Shepel’ Artem O. , Kramskaia Liudmila V. , Oskirko Denis A. , Frolova Olga S.
Published: April 2020

The article presents the experience of 19 Russian medical institutions on the use of eribulin in combination with trastuzumab in various treatment lines of metastatic HER2+ breast cancer in routine clinical practice.
Aim. The main objective of this retrospective observational study was to evaluate the efficacy and tolerability of eribulin and trastuzumab combo in HER2+ breast cancer patients pretreated with anthracyclines and taxanes. The analysis included 60 patients who received at least 2 cycles of eribulin in combination with trastuzumab. 2 patients (3.3%) received treatment as the 1st line, as the 2nd 14 (23.3%), as the 3rd 16 (26.7%), and as the 4th and more 28 (46.7%).
Materials and methods. Complete response was achieved in 2 (3.3%) patients, partial response in 9 (15%), stable disease in 33 (55%), stabilization for more than 6 months in 11 (18.3%), disease progression was detected in 16 (26.7%) patients. The objective response rate was 18.3% in the whole group, the clinical benefit rate 36.7%.
Results. The objective response rate in the group of the luminal subtype (ER/PR+HER2+) was 26.9%, in HER2-overexpressed subtype (ER-PR-HER2+) 8.8% and 64.7%, respectively, disease progression was recorded 2.3 times more often 35.3% versus 15.5% in the luminal subtype group. The median progression-free survival in patients with HER2+ breast cancer was 4.95 months (95% confidence interval CI 3.048.29 months), in luminal subtype 6.38 months (95% CI 3.338.54 months), in non-luminal 4.44 months (95% CI 2.47.96 months); p=0.306. The treatment was well tolerated, the spectrum of adverse events corresponded to the eribulin toxicity profile.
Conclusions. The uniqueness of this study lies in the fact that on a large clinical material from the standpoint of real clinical practice, a very promising treatment regimen that is not used routinely in a number of countries has been studied, its effectiveness and satisfactory tolerance have been confirmed.
Hairy cell leukemia. Clinical recommendations
Authors: Al’-Radi Liubov S. , Baikov Vadim V. , Kovrigina Alla M. , Krivolapov Iurii A. , Moiseeva Tatiana N. , Nikitin Evgenii A. , Pivnik Aleksandr V. , Stadnik Elena A. , Nevol’skikh Aleksei A. , Ivanov Sergei A. , Khailova Zhanna V. , Gevorkian Tigran G.
Published: April 2020

Hairy cell leukemia. Clinical recommendations
引入英文电影提升大二英语写作课境界——以电影《绿皮书》为例
Authors: 王 沁丛
Published: April 2020

本文以电影《绿皮书》为例，论述了如何利用英语电影这一有效载体，从语言习得、文化认知和情感教学等多个层面进行赏析和渗透，激发大二学生在写作课上的表达欲望，培养其跨文化交际的意识和批判性思考的能力，使课堂的境界上升到更高层次。
浅谈在义务教育阶段如何用师爱教育失爱的学生
Authors: 刘 菁华
Published: April 2020

曾有一位老师这样说过：真诚的师爱是开辟通向学生心灵的通道，是打开学生心扉禁区的钥匙，是架起师生融洽关系的桥梁。对于生活中因失爱导致品德不良、心理不健康、意志不坚强、心胸狭窄，无视前途、自暴自弃的学生，用真诚的师爱去弥补他们缺失的亲情之爱，用体贴入微的师爱去慰藉他们受伤的心灵，用博大宽容的师爱去包容他们的劣行劣迹，用爱生如子的师爱去唤起他们对生活的热爱、对未来的憧憬。实践证明，用师爱浇灌的花朵确实鲜艳，用师爱培育的桃李确实丰硕，用师爱教育失爱的学生也是最有效的教育方法。
体育院校职业生涯规划与就业指导课课程思政改革的探索与实践
Authors: 王 卫英
Published: April 2020

体育院校职业生涯规划与就业指导课课程思政改革既是提升思想政治教育实效性、实现立德树人根本任务的需要，也是促进体育大学生全面发展，适应现代社会发展要求的需要。文章立足体育院校实际，从进一步提高教师德育意识和课程思政能力、优化课程设计、改进教学方法、改进考核评价方式四个方面进行课程思政的探索和尝试，力求不断提高职业生涯规划与就业指导课教学质量和育人实效，更好地引导和服务体育大学生成长成才。
Ciências na educação infantil: explorando a idade dos porquês
Authors: Jardim Loraine Rodrigues
Published: April 2020

A educação infantil é a primeira etapa da educação básica, tendo como finalidade o desenvolvimento integral da criança até cinco anos de idade. O objetivo deste trabalho foi verificar como aproveitar a fase de curiosidade infantil para a construção de conhecimentos de ciências. Tendo a legislação e a descrição de estudiosos da área da educação infantil como norteadores, foi realizada uma pesquisa bibliográfica em busca de descrever as possibilidades de atividades a serem desenvolvidas na educação infantil. Como sugestão de atividades destacamos a construção de horta, a produção de picolés, a hora da história e os momentos de higiene. Concluímos que é preciso conhecer as fases de desenvolvimentos das crianças e as suas potencialidades.