bluuebunny/crossref_metadata_2025 huggingface dataset:
Miz1 Controls Schwann Cell Proliferation via H3K36me2Demethylase Kdm8 to Prevent Peripheral Nerve Demyelination
Authors: Fuhrmann David , Mernberger Marco , Nist Andrea , Stiewe Thorsten , Elsässer Hans-Peter
Published: December 2017

Schwann cell differentiation and myelination depends on chromatin remodeling, histone acetylation, and methylation, which all affect Schwann cell proliferation. We previously reported that the deletion of the POZ (POxvirus and Zinc finger) domain of the transcription factor Miz1 (Myc-interacting zinc finger protein; encoded byZbtb17) in mouse Schwann cells (Miz1ΔPOZ) causes a neuropathy at 90 d after birth [postnatal day (P) 90], with a subsequent spontaneous regeneration. Here we show that RNA sequencing fromMiz1ΔPOZand control animals at P30 revealed a set of upregulated genes with a strong correlation to cell-cycle regulation. Consistently, a subset of Schwann cells did not exit the cell cycle as observed in control animals and the growth fraction increased over time. From the RNAseq gene list, two direct Miz1 target genes were identified, one of which encodes the histone H3K36me2demethylase Kdm8. We show that the expression ofKdm8is repressed by Miz1 and that its release inMiz1ΔPOZcells induces a decrease of H3K36me2, especially in deregulated cell-cycle-related genes. The linkage between elevatedKdm8expression, hypomethylation of H3K36 at cell-cycle-relevant genes, and the subsequent re-entering of adult Schwann cells into the cell cycle suggests that the release ofKdm8repression in the absence of a functional Miz1 is a central issue in the development of theMiz1ΔPOZphenotype.

SIGNIFICANCE STATEMENTThe deletion of the Miz1 (Myc-interacting zinc finger protein 1) POZ (POxvirus and Zinc finger) domain in Schwann cells causes a neuropathy. Here we report sustained Schwann cell proliferation caused by an increased expression of the direct Miz1 target geneKdm8, encoding a H3K36me2 demethylase. Hence, the demethylation of H3K36 is linked to the pathogenesis of a neuropathy.
Repositioning of Somatic Golgi Apparatus Is Essential for the Dendritic Establishment of Adult-Born Hippocampal Neurons
Authors: Rao Sneha , Kirschen Gregory W. , Szczurkowska Joanna , Di Antonio Adrian , Wang Jia , Ge Shaoyu , Shelly Maya
Published: December 2017

New dentate granule cells (DGCs) are continuously generated, and integrate into the preexisting hippocampal network in the adult brain. How an adult-born neuron with initially simple spindle-like morphology develops into a DGC, consisting of a single apical dendrite with further branches, remains largely unknown. Here, using retroviruses to birth date and manipulate newborn neurons, we examined initial dendritic formation and possible underlying mechanisms. We found that GFP-expressing newborn cells began to establish a DGC-like morphology at ∼7 d after birth, with a primary dendrite pointing to the molecular layer, but at this stage, with several neurites in the neurogenic zone. Interestingly, the Golgi apparatus, an essential organelle for neurite growth and maintenance, was dynamically repositioning in the soma of newborn cells during this initial integration stage. Two weeks after birth, by which time most neurites in the neurogenic zone were eliminated, a compact Golgi apparatus was positioned exclusively at the base of the primary dendrite. We analyzed the presence of Golgi-associated genes using single-cell transcriptomes of newborn DGCs, and among Golgi-related genes, found the presence ofSTK25andSTRAD, regulators of embryonic neuronal development. When we knocked down either of these two proteins, we found Golgi mislocalization and extensive aberrant dendrite formation. Furthermore, overexpression of a mutated form of STRAD, underlying the disorder polyhydramnios, megalencephaly, and symptomatic epilepsy, characterized by abnormal brain development and intractable epilepsy, caused similar defects in Golgi localization and dendrite formation in adult-born neurons. Together, our findings reveal a role for Golgi repositioning in regulating the initial integration of adult-born DGCs.

SIGNIFICANCE STATEMENTSince the discovery of the continuous generation of new neurons in the adult hippocampus, extensive effort was directed toward understanding the functional contribution of these newborn neurons to the existing hippocampal circuit and associated behaviors, while the molecular mechanisms controlling their early morphological integration are less well understood. Dentate granule cells (DGCs) have a single, complex, apical dendrite. The events leading adult-born DGCs' to transition from simple spindle-like morphology to mature dendrite morphology are largely unknown. We studied establishment of newborn DGCs dendritic pattern and found it was mediated by a signaling pathway regulating precise localization of the Golgi apparatus. Furthermore, this Golgi-associated mechanism for dendrite establishment might be impaired in a human genetic epilepsy syndrome, polyhydramnios, megalencephaly, and symptomatic epilepsy.
Overexpression of the Histone Dimethyltransferase G9a in Nucleus Accumbens Shell Increases Cocaine Self-Administration, Stress-Induced Reinstatement, and Anxiety
Authors: Anderson Ethan M. , Larson Erin B. , Guzman Daniel , Wissman Anne Marie , Neve Rachael L. , Nestler Eric J. , Self David W.
Published: December 2017

Repeated exposure to cocaine induces lasting epigenetic changes in neurons that promote the development and persistence of addiction. One epigenetic alteration involves reductions in levels of the histone dimethyltransferase G9a in nucleus accumbens (NAc) after chronic cocaine administration. This reduction in G9a may enhance cocaine reward because overexpressing G9a in the NAc decreases cocaine-conditioned place preference. Therefore, we hypothesized that HSV-mediated G9a overexpression in the NAc shell (NAcSh) would attenuate cocaine self-administration (SA) and cocaine-seeking behavior. Instead, we found that G9a overexpression, and the resulting increase in histone 3 lysine 9 dimethylation (H3K9me2), increases sensitivity to cocaine reinforcement and enhances motivation for cocaine in self-administering male rats. Moreover, when G9a overexpression is limited to the initial 15 d of cocaine SA training, it produces an enduring postexpression enhancement in cocaine SA and prolonged (over 5 weeks) increases in reinstatement of cocaine seeking induced by foot-shock stress, but in the absence of continued global elevations in H3K9me2. The increase in stress-induced reinstatement is paralleled by heightened anxiety measures, suggesting that countering the cocaine-induced decreases in endogenous G9a with ectopic G9a overexpression leads to lasting anxiogenic effects. Finally, we found an enduring reduction in phosphorylated cAMP-response element binding protein levels in the NAcSh that could account for the increased anxiety. These data demonstrate a novel role for G9a in promoting comorbid cocaine addiction and anxiety and suggest that increased epigenetic repression of transcription through H3K9 during cocaine use can have long-lasting and unexpected negative consequences on behavior.

SIGNIFICANCE STATEMENTCocaine addiction is a neuropsychiatric disorder that is detrimental to society and currently has no effective treatments. The difficulty in treating drug addiction is compounded by the high comorbidity with other psychiatric illnesses, including anxiety disorders. Here, we demonstrate that G9a, an epigenetic repressor of gene expression, acting in the nucleus accumbens, a brain reward region, is capable of increasing both addiction- and anxiety-like behaviors in rats. These findings are intriguing because repeated cocaine exposure decreases G9a in this region and thereby enhances expression of certain addiction-promoting genes. However, our results suggest that countering this cocaine-induced decrease in G9a activity actually exacerbates addiction and sensitivity to relapse under stressful situations.
Synaptic Regulator α-Synuclein in Dopaminergic Fibers Is Essentially Required for the Maintenance of Subependymal Neural Stem Cells
Authors: Perez-Villalba Ana , Sirerol-Piquer M. Salomé , Belenguer Germán , Soriano-Cantón Raúl , Muñoz-Manchado Ana Belén , Villadiego Javier , Alarcón-Arís Diana , Soria Federico N. , Dehay Benjamin , Bezard Erwan , Vila Miquel , Bortolozzi Analía , Toledo-Aral Juan José , Pérez-Sánchez Francisco , Fariñas Isabel
Published: December 2017

Synaptic protein α-synuclein (α-SYN) modulates neurotransmission in a complex and poorly understood manner and aggregates in the cytoplasm of degenerating neurons in Parkinson′s disease. Here, we report that α-SYN present in dopaminergic nigral afferents is essential for the normal cycling and maintenance of neural stem cells (NSCs) in the brain subependymal zone of adult male and female mice. We also show that premature senescence of adult NSCs into non-neurogenic astrocytes in mice lacking α-SYN resembles the effects of dopaminergic fiber degeneration resulting from chronic exposure to 1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine or intranigral inoculation of aggregated toxic α-SYN. Interestingly, NSC loss in α-SYN-deficient mice can be prevented by viral delivery of human α-SYN into their sustantia nigra or by treatment withl-DOPA, suggesting that α-SYN regulates dopamine availability to NSCs. Our data indicate that α-SYN, present in dopaminergic nerve terminals supplying the subependymal zone, acts as a niche component to sustain the neurogenic potential of adult NSCs and identify α-SYN and DA as potential targets to ameliorate neurogenic defects in the aging and diseased brain.

SIGNIFICANCE STATEMENTWe report an essential role for the protein α-synuclein present in dopaminergic nigral afferents in the regulation of adult neural stem cell maintenance, identifying the first synaptic regulator with an implication in stem cell niche biology. Although the exact role of α-synuclein in neural transmission is not completely clear, our results indicate that it is required for stemness and the preservation of neurogenic potential in concert with dopamine.
Detecting Recent Positive Selection with a Single Locus Test Bipartitioning the Coalescent Tree
Authors: Yang Zongfeng , Li Junrui , Wiehe Thomas , Li Haipeng
Published: December 2017

Many population genomic studies have been conducted in the past to search for traces of recent events of positive selection. These traces, however, can be obscured by temporal variation of population size or other demographic factors. To reduce the confounding impact of demography, the coalescent tree topology has been used as an additional source of information for detecting recent positive selection in a population or a species. Based on the branching pattern at the root, we partition the hypothetical coalescent tree, inferred from a sequence sample, into two subtrees. The reasoning is that positive selection could impose a strong impact on branch length in one of the two subtrees while demography has the same effect on average on both subtrees. Thus, positive selection should be detectable by comparing statistics calculated for the two subtrees. Simulations demonstrate that the proposed test based on these principles has high power to detect recent positive selection even when DNA polymorphism data from only one locus is available, and that it is robust to the confounding effect of demography. One feature is that all components in the summary statistics (Du) can be computed analytically. Moreover, misinference of derived and ancestral alleles is seen to have only a limited effect on the test, and it therefore avoids a notorious problem when searching for traces of recent positive selection.
Language and masculinity
Authors: SturtzSreetharan Cindi
Published: December 2017

The unexpected use of Osaka dialect in the 2013 film Like Father, Like Son directed by Hirokazu Kore’eda, presents an opportunity to scrutinise its role in indexingmasculinity, class and fatherhood. The film depicts two styles of fatherhood: one, a cool and disconnected father representing the archetypal upper-middle class but absent salaryman patriarch; the other, a warm and emotionally connected father representing a new kind of patriarch who is engaged in child rearing. These contrasting styles are indexed linguistically through standard Japanese and Osaka dialect respectively. Extending the framework of a sociolinguistics of the periphery to a case of internal language variation, the mobility of Osaka dialect is highlighted. Specifically, through the process of translocalisation, the enregistered indices of Osaka dialect mediate the creation of a new social type: the caring and connected father.
Media articulations of gender and sexuality
Authors: Hiramoto Mie , Kang M. Agnes
Published: December 2017

Acknowledgements
 
This special issue presents articles based on presentations at the Sociolinguistics of Globalization conference that was held in Hong Kong in June of 2015. The conference was hosted by the Department of English at the University of Hong Kong. We thank the conference participants for useful feedback. Our sincere thanks also go to Tommaso Milani and Michelle Lazar for their invaluable assistance.
“Argentina is cumbia”
Authors: Silba Malvina
Published: December 2017

This article analyses the sociocultural trajectories of a group of young men with a low socioeconomic status, all cumbia musicians and producers. The cumbia is one of Argentina’s most popular music genres due to its mass dissemination and the social class of the people who have historically enjoyed it. The tension between agency and structure and the relationship between class and culture will be the main themes explored in this article. By focusing on the family, education and work trajectories of these youths, I examine their relationship to cumbia music. Who chooses to become a cumbia musician, and why? I also examine the meanings of “good” versus “bad” music” and the aesthetic and moral parameters used for its definition. This brings me to class belonging and how it shapes musical choices and facilitates disruptive trajectories. The article is based on biographical interviews conducted between 2012 and 2014, combined with participant observation at cumbia dance clubs in Greater Buenos Aires.
La inteligencia científico-tecnológica para el desarrollo y la seguridad geoeconómica latinoamericana/ The scientific-technological intelligence for development and the Latin American geoeconomic security
Authors: Viamonte Garrido Yoan Israel
Published: December 2017

Las agendas de seguridad e inteligencia latinoamericanas se han centrado casi exclusivamente al tratamiento de los temas clásicos de la Seguridad en sus dimensiones político-militar y policíaco-criminalística. Sin embargo, una dimensión, con creciente importancia estratégica, como es una agenda de seguridad geoeconómica con un mecanismo de inteligencia científica y tecnológica, orientado al desarrollo a través de Sistemas Nacionales de Innovación, ha sido ignorada hasta hoy. En el presente trabajo se propone tanto un modelo como un concepto de Inteligencia Científica y Tecnológica para el Desarrollo (ICTD) dentro de una agenda de seguridad geoeconómica.

 

 

Abstract

The Latin American Security and Intelligence agendas have been focused almost exclusively on the treatment of the classic themes of Security in its political – military and police – criminalistics dimensions. However, another dimension with increasing strategic importance such as a Geo-economics Security agenda with a Scientific and Technological Intelligence mechanism oriented to Development through National Systems of Innovation have been ignored until today. In the present paper, both a model and a concept of Scientific and Technological Intelligence for Development (STID) within a Geo-economics Security agenda it´s produced.
La evolución de la política de inteligencia militar argentina: rupturas y continuidades (1990-2015)/ The evolution of Argentine ´ s military intelligence policy: ruptures and continuities (1990-2015)
Authors: Poczynok Iván
Published: December 2017

El artículo analiza los factores políticos que atravesaron la definición de la política de inteligencia militar argentina entre 1990 y 2015. El argumento central es que esta responsabilidad estuvo condicionada por dos apreciaciones ampliamente arraigadas en los gobiernos del período: que la inteligencia militar constituye un instrumento peligroso para la estabilidad democrática; y que la Argentina carece de problemas externos que puedan requerir la generación de este tipo de conocimientos en el mediano plazo. Estos elementos no sólo tornaron accesoria –desde la mirada de las élites locales– la definición de una política de inteligencia, sino que también configuraron un status quo que reprodujo la subordinación de los intereses defensivos del país a las preocupaciones estratégicas de otras naciones.

 

Abstract

This article analyzes the political factors that crossed the definition of Argentine´s military intelligence policy between 1990 and 2015. The argument is that this activity was conditioned by two assumptions widely held by the governments of this period: that military intelligence is dangerous for democratic stability; and that Argentina does not have external problems that may require this type of knowledge in the medium term. These elements not only made “unnecessary” the definition of an intelligence policy -from the perspective of the local elites- but also shaped a status quo that maintained the subordination of the country's defense interests to foreign strategic perceptions.
La inteligencia militar ecuatoriana en la sociedad del riesgo/ The ecuadorian military intelligence in the risk society
Authors: Ordóñez María Dolores , Cruz Galo
Published: December 2017

La evolución y las nuevas lecturas de los riesgos que azotan al mundo obligan a reconfigurar el rol de las instituciones militares y por lo tanto sus funciones de inteligencia. El salto desde la llamada modernidad hacia unas formas que rebasarían los postulados de esta y en la que las sociedades están sometidas a las lógicas del mercado y de la burocracia, las consideraciones sobre los riesgos y la seguridad, no siempre tienen que ver con las condiciones que ponen en peligro la vida humana, sino también con la gobernabilidad, la estabilidad económica, la opinión pública, entre otras problemáticas. Desde la perspectiva de Anthony Giddens y Ulrich Beck, se hará una reflexión sobre las dimensiones que deben tomar en cuenta la inteligencia militar en los ejércitos contemporáneos, ajustadas a realidades en que los “sistemas abstractos” predominan y que exigen desarrollar una inteligencia estratégica que no se constriñe únicamente al ámbito nacional y de soberanía territorial. Para esto se tomará como ejemplo las prioridades actuales de la inteligencia militar en Ecuador y las necesidades de reinventarse cuando se encuentran en unas condiciones de transición de un modelo tradicional hacia uno global, más aún cuando tienen que actuar en este contexto de riesgo, con medios que no se ajustan a esta realidad, toda vez que la capacidad científico-tecnológica y, por tanto, las concepciones doctrinarias de inteligencia, no se inscriben todavía en las dinámicas globalizadoras.

 

 

Abstract

Development and new lectures regarding world’s current risks compel us to reconfigure the role of military institutions and, therefore, their purpose regarding intelligence. The transition from modernity to new forms that would exceed its postulates , in which societies are summited to the logics of market and bureaucracy, as well as the analysis about risks and security are not always related to the conditions that could be considered a threat to human life, but also to governability, economic stability, public opinion, among other problems. From the perspective of Anthony Giddens and Ulrich Beck, there will be a reflection about the dimensions that must be considered by military intelligence of contemporary army forces, adjusted to realities where the “abstract systems” dominate and demand the development of a strategic intelligence that doesn’t constrict itself to cover national and territorial sovereignty issues only. In order to achieve this there will be an examination of nowadays priorities for the military intelligence of Ecuador and the necessity to reinvent itself during the transition from a traditional to a global outline, moreover, when they have to act in this risk context, with sources that do not adjust to this reality, since the scientific-technological capacity and, therefore, the intelligence doctrinal conceptions, are not still inscribed in the globalizing dynamics.
Entre el cambio y la inercia histórica: el contexto actual de la inteligencia militar en Suramérica/ Between change and historical inertia: the current context of military intelligence in South America
Authors: Cabrera Toledo Lester Martin
Published: December 2017

El artículo aborda algunos de los aspectos, tanto históricos como actuales, que determinan la concepción de la inteligencia militar en América del Sur. Para lo anterior, se toman en cuenta la influencia de los elementos doctrinarios clásicos del pensamiento militar, la existencia de un eventual cambio de paradigma en la comprensión de los procesos conflictivos y en las propias dimensiones de la inteligencia, y la incorporación de otros elementos que derivarían en la adopción de otros parámetros analíticos para la temática señalada. Lo anterior da paso para el planteamiento de algunos desafíos que la región mantiene en labores de inteligencia militar, siempre considerando una división entre la mantención de una concepción clásica del conflicto, y la adopción de nuevas tendencias en el campo de la guerra. Se concluye que pese al esfuerzo de mantener las nociones clásicas de la guerra aplicadas a la inteligencia militar, los países de la región deben incorporar otros esquemas de pensamiento, lo que se asocian a una comprensión más compleja de los fenómenos conflictivos que afectan tanto al Estado como a las sociedades, pero no como una función subsidiaria, sino que complementaria a la que tradicionalmente ejecutan.

Abstract

This article studies some historical and current aspects that determine the conception of military intelligence in South America. To do that, it's consider the influence of the classic doctrinal elements of military thought, the existence of an eventual change of paradigm in the understanding of the conflictive processes and in the own dimensions of the intelligence, and the incorporation of other elements that would result in the adoption of other analytical parameters for the aforementioned subject. This conduces to the approach of some challenges that the region maintains in military intelligence tasks, always considering a division between the maintenance of a classic conception of the conflict and the adoption of new tendencies in the field of war. It is concluded that despite the effort to maintain the classic notions of war applied to military intelligence, the countries of the region must incorporate other thought schemes, which are associated with a more complex understanding of the conflicting phenomena that affect both the State as to societies, not as a subsidiary function but as a complement to the one they traditionally execute.
Reseña: El uso interno de las fuerzas militares de Estados Unidos en la “Guerra contra las Drogas”
Authors: Concha Villanueva Sebastián Andrés
Published: December 2017

El objetivo de este trabajo es reseñar el estudio de Germán Montenegro titulado El uso interno de las fuerzas militares de Estados Unidos en la "Guerra contra las Drogas", publicado por la Universidad Metropolitana para la Educación y el Trabajo de Argentina. Frente a la meta del texto, que es elaborar una breve descripción del proceso de militarización para el control de las drogas en Estados Unidos, se argumenta que, pese a ser un excelente resumen, no establece un abordaje crítico que levante una interpretación sobre el tema que trata.
High quality DNA from Fungi for long read sequencing e.g. PacBio, Nanopore MinION v4
Authors: Schwessinger and Megan McDonald Benjamin
Published: December 2017

Extraction of high quality DNA for long read sequencing e.g. PacBio and MinIon Optimized for DNA extraction fromBipolaris sorokiniana. Also tested on Parastaognospora nodorum, Zymoseptoria tritici, wheat stripe rust, barley stripe rust and Pyrenophora tritici-repentis Buffers are best when fresh and not older than 3-6 months. Buffered Phenol:Chloroform:Isoamylalcohol (25:24:1) should not be older than 3 months. Critical steps to obtain high quality DNA: Do NOT heat samples during DNA extractions! Perform all steps at RT or 4oC as indicated. Do NOT incubate samples with KAc for prolonged time periods Perform two steps of buffered Phenol:Chloroform:Isoamylalcohol purification to reduce co-purifying metabolites. DNA fragments were well above the 40kb mark based on Pippin Pulse Gels. The sequencing center performed a second AMPure purification step before library construction.
Laboratory for Integrative Neuroscience Immunofluorescence Protocol v2
Authors: I. Davis Margaret
Published: December 2017

This is the general immunofluorescence protocol used in the Laboratory for Integrative Neuroscience at NIAAA. This protocol can be adapted for most primary antibodies but specific antibodies and concentrations need to be determined by the user and the protocol adapted accordingly. Secondary antibodies listed are optimal for the Axiozoom and LSM880 filters and excitation sources and may need to be changed to match the microscope available. I also provide tips for optimizing staining, reducing background, and characterizing antibodies.
THE INTERNATIONAL COMPETITIVENESS AND TARGET MARKETS OF COLOMBIAN BLACKBERRIES
Authors: Sellamén Garzón Alexander , Camacho Murillo Andrés
Published: December 2017

This document analyzes the international competitiveness of Colombian blackberries-raspberries between 2003-2007, as well as its potential markets worldwide resulting from some theories and concepts related to international commerce and competitiveness given by authors such as Bela Balassa (1964 y 1970), Schwartz, M., et al. (2007), and the Corporación Colombia Internacional, among others. The result shows that this Colombian product has a worldwide productive and competitive potential that can motivate exporting it to potential countries like Canada, USA, the United Kingdom and France.
LA ORGANIZACIÓN COMO SISTEMA COMPLEJO: IMPLICACIONES PARA LA CONCEPTUALIZACIÓN DEL LIDERAZGO
Authors: CONTRERAS TORRES FRANCOISE , BARBOSA RAMÍREZ DAVID , CASTRO RÍOS GUIDO ANGELLO
Published: December 2017

Se revisaro n las implicaciones que tiene para el liderazgo el pasar de una visión convencional, en la que la organización se asemeja a una máquina y es función del líder promover su estabilidad y decidir el camino, a los recientes adelantos en los que la organización se asume como un sistema complejo que a través de la autoorganización logra generar nuevas formas que le permiten adaptarse. Esta perspectiva involucra profundos cambios en el concepto de liderazgo, menos centrado en el líder y más en los procesos de liderazgo que emergen en el sistema como producto de la interacción entre agentes. A través de un liderazgo colaborativo, los líderes deben llevar a la organización a estados lejos del equilibrio, para promover el aprendizaje y la innovación, aspectos esenciales para la perdurabilidad empresarial.
LAS TRANSICIONES DEMOCRÁTICAS EN EL ORIENTE MEDIO. UN ANÁLISIS CRÍTICO DESDE LA PERSPECTIVA DE LAS TEORÍAS POLÍTICAS OCCIDENTALES
Authors: AHMED GHOTME RAFAT
Published: December 2017

En este estudio se verá que la teoría política del Oriente Medio no encaja adecuadamente en las teorías políticas occidentales, incluso si se trata de una transición democrática de corte modernista. Si bien las teorías occidentales pueden proveer una comprensión para entender comparativamente los sucesos de la transición democrática en Oriente Medio, todas estas teorías no pueden aplicarse a las realidades sociales y políticas en esa región, determinadas por redes culturales, la religión y las identidades tribales, que propenderán por crear una supuesta democratización –que, en caso de darse–, se sostendría bajo una forma particular de democracia estructurada en las complejas interacciones entre entidades heterogéneas, las tensiones sociales y las diferentes identidades
EL MOBBING: ¿EL CRIMEN PERFECTO? NO, QUÉ MÁS QUISIERAN “ALGUNOS”.
Authors: Verona Martel María Concepción , Santana Mateo Raquel
Published: December 2017

El mobbing ocupa, desgraciadamente, en el mundo laboral del siglo XXI un destacado papel. En este proceso están implicadas no solo las víctimas (que son las más perjudicadas), sino también los acosadores (que con más frecuencia que la que sería deseable en una sociedad sana y ética quedan libres del delito cometido) y las empresas (fomentadoras o tolerantes, en la mayoría de las ocasiones, de tan flagrante delito contra la dignidad y respeto tanto intelectual como personal de la víctima).
MARCAS DEL DISTRIBUIDOR: EVOLUCIÓN Y CARACTERIZACIÓN DEL CONCEPTO
Authors: MEDINA VALENCIA JAQUELINE , DUQUE OLIVA EDISON JAIR
Published: December 2017

En las últimas décadas es notable el auge que han experimentado las marcas del distribuidor, dejando como consecuencia un cambio sustancial en las preferencias de los consumidores y un cambio en las dinámicas del canal de distribución. Con ello la existencia de las marcas gestionadas por los distribuidores minoristas se pueden considerar como un fenómeno complejo que tiene múltiples y variadas implicaciones para cada uno de los actores involucrados: consumidores, fabricantes y distribuidores. Ante este panorama la presente investigación se centra en dilucidar tres cuestiones básicas: ¿Qué son las marcas del distribuidor?, ¿por qué los distribuidores gestionan sus propias marcas? y ¿cuáles son los factores que pueden incidir en el éxito o fracaso de las mismas?, con el fin de brindar desde una perspectiva general mayor claridad sobre el fenómeno en cuestión.
O Desenvolvimento como Discurso: um estudo sobre Anchieta (ES)
Authors: Mattos Sônia Missagia
Published: December 2017

Resumo: este artigo tem por base questões levantadas a partir de pesquisas

realizadas em Anchieta, ES e focaliza um modelo de desenvolvimento, ancorado

por metas de crescimento da produção industrial e da infraestrutura. ?

um modelo próprio de grandes projetos de desenvolvimento econômicos, que

favorece apenas às elites de poder.

Palavras-chave: Grandes Projetos de Desenvolvimento. Migração Forçada.
Panorama Guarani (Mbyá, Nhãdeva, Kayová, Chiriguano)
Authors: Guimarães Sílvia Maria Ferreira
Published: December 2017

Mediante uma consulta intensiva da bibliografia guarani e de

dados coletados na aldeia do grupo guarani-mbyá de Tecoa Porã, no estado de Espírito Santo, este artigo pretende discutir a maneira como, ao longo do tempo e do espaço, grupos falantes da língua guarani experimentaram eventos e criaram sobre um suposto complexo sociocosmológico tupi-guarani.
Arqueologia da Paisagem e a Potencialidade Interpretativa dos Espaços Sociais
Authors: Sousa Ana Cristina de
Published: December 2017

Este artigo visa a discutir aspectos relacionados à  potencialidade interpretativa dos espaços sociais, num reconhecimento de que a sua incorporação como objeto de análise arqueológica pressupõe lidar com seu duplo aspecto, como produto e vetor de relações sociais. Neste sentido, o espaço não se constitui em um mero reflexo de processos socioculturais, mas atua como um de seus fatores constitutivos, interferindo em sua configuração simbólica, recebendo, processando e transmitindo mensagens sociais.
O Registro de Manifestações Culturais Tradicionais ou uma Aventura pelos Novos Caminhos das Políticas Públicas Brasileiras
Authors: Amorim Lara Santos de
Published: December 2017

O artigo discute como uma manifestação tradicional a Folia do Divino está sujeita à s amplas negociações de sentido que fazem parte da dinâmica dos processos culturais contemporâneos. A etnografia sobre a Folia de Formosa, em Goiás, indica a dinâmica da produção da festa e sua relação com o campo de poder da sociedade globalizada. Discute-se, neste contexto, a pertinência das políticas públicas de patrimônio imaterial implementadas pelo IPHAN e o papel do antropólogo neste processo.
Missionários da Consolata Aqui e na àfrica
Authors: Araújo Melvina Afra Mendes de
Published: December 2017

Este texto tem por objetivo analisar a influência da experiência africana no remodelamento das relações entre missionários da Consolata e índios Macuxi em Roraima, Brasil, particularmente após os anos 1970. Para tanto, enfocaremos sobretudo o envolvimento dos consolatinos no processo de organização política indígena em torno de questões relativas à  garantia de seus direitos territoriais e de valorização étnica.
Universidades e Transformações Socioambientais: Contribuições da Aprendizagem Transformadora e da Teoria da Atividade Histórico Cultural
Authors: Alves Pacheco de Campos Simone , Celia Palma Lisiane , Avila Pedrozo Eugenio
Published: December 2017

Muito se tem discutido a respeito do papel das universidades frente aos problemas socioambientais. Contudo, os avanços em direção a uma transformação parecem poucos, permanecendo as universidades presas ao mainstrean. A transformação exige que as universidades se desvencilhem do que Freire (1987) chama de educação bancária. Considerando o ensino em administração, essa transformação exige uma separação da ortodoxia gerencialista que domina a área, visto que o contexto atual exige uma postura reflexiva e crítica ante aos problemas socioambientais. Fala-se muito em responsabilidades coletivas e institucionais. Contudo, pouco se atenta para a necessidade real de revisão da responsabilidade individual e de como engajar os indivíduos na sociedade enquanto cidadãos conscientes de seu papel socioambiental. É amplamente conhecido que os indivíduos têm um papel fundamental a desempenhar na concretização de transformações para a sustentabilidade. Mais do que o entendimento acerca de uma educação voltada para a sustentabilidade, deve-se pensar em como impulsionar os indivíduos a agir com vistas à transformação do futuro. Inserido nesta preocupação, este ensaio tem como argumento central que as mudanças em direção à consciência socioambiental perpassam a agência individual e coletiva, com vistas à transformação. Neste processo, as universidades têm um papel central, na medida em que podem ser organizações promotoras desta transformação. Para tanto, buscou-se subsídios na teoria da aprendizagem transformadora e na teoria da atividade histórico cultural para uma compreensão crítica acerca de como as universidades podem promover um aprendizado voltado ao desenvolvimento da agência transformadora e assim engajar os indivíduos na sociedade enquanto cidadãos conscientes de seu papel socioambiental.
Исследование востребованности услуг досуговых организаций г. Новосибирска потребителями третьего возраста
Authors: Загорская Любовь Михайловна , Назаркина Валерия Александровна
Published: December 2017

Статья посвящена изучению востребованности услуг досуговых организаций г. Новосибирска потребителями третьего возраста.
Актуальность темы исследований определяется, во-первых, ростом количества пенсионеров в России и Сибирском регионе, во-вторых, изменением базовых ценностей людей старшего возраста в части организации и проведения досуга, и, в-третьих, повышением их мотивации к уровню, содержанию и степени полезности досуговых услуг.
Рассматривается состояние рынка услуг для людей старшего возраста по направлениям: фитнес услуги, танцевальные услуги, оздоровительные услуги с использованием традиций восточных практик и культурно-творческие услуги. Для подтверждения гипотезы приводятся результаты исследований потребностей возрастной группы потребителей старше 55 лет, проводимые в течение нескольких лет, начиная с 2015 г. Выводы исследований показывают, что потенциал данной группы в области потребления услуг, слабо изучен и практически не востребован досуговыми организациями г.Новосибирска, и, соответственно, требует изменения маркетинговой стратегии организаций социально-культурной сферы.
Практические аспекты формирования ценовой политики предприятия оптовой торговли
Authors: Розумная Наталья Вячеславовна , Беляев Тимофей Евгеньевич
Published: December 2017

В статье рассмотрены вопросы формирования ценовой политики предприятий оптовой торговли; проведен анализ развития оптовой торговли в России. Построена регрессионная модель зависимости объема продаж от цены для предприятия оптовой торговли. Разработаны рекомендации по совершенствованию ценовой политики компании.
Статья посвящена проблемам ценообразования на отечественных предприятиях, вопросам обоснования эффективной ценовой политики современных компаний, функционирующих в условиях жесткой ценовой конкуренции.
Особенности оценки качества туристских услуг
Authors: Колочева Влада Владимировна
Published: December 2017

В статье рассмотрены показатели и методы оценки качества услуг. Автором дана методика определения уровня качества туристских услуг. Особое внимание в статье уделено определению номенклатуры показателей качества, учитывающей требования потребителей и положения нормативных документов.
Статья посвящена решению проблемы принятия управленческих решений на основе оценки качества услуг туристкой организации. Материал, изложенный в статье, будет интерес участникам туристкой деятельности, а также специалистам, занимающимся вопросами оценки и управления качеством услуг.
Роль проектно-ориентированного подхода в инновационном развитии организации культурно-досуговой сферы
Authors: Загорская Любовь Михайловна , Назаркина Валерия Александровна
Published: December 2017

Статья посвящена изучению преимуществ проектно-ориентированного подхода по сравнению с традиционным, функциональным подходом в деятельности организаций культурно-досуговой сферы. Актуальность темы исследований определяется, во-первых, слабой изученностью данной проблематики с точки зрения роли этого подхода в развитии организации культурно-досугового типа, во-вторых, необходимостью изучения накопленного опыта реализации социально-значимых проектов некоммерческими организациями в Сибирском регионе.
В статье рассматривается проблематика использования проектно-ориентированного подхода организациями трех типов: некоммерческими, государственными и коммерческими в Сибирском регионе. Дается обзор проектов социальной значимости для узких целевых групп населения: детей-инвалидов, пожилых людей и др. Основной вывод изучения опыта некоммерческих организаций заключается в том, что самая низкая доля социально-культурных проектов адресована пожилым людям. Культурно-досуговым учреждениям и досуговым организациям следует более активно использовать проектно-ориентированный подход к организации досуга узких целевых групп, и в условиях ограниченных ресурсов – включаться в проекты, разработанные некоммерческими организациями на правах партнеров. В результате организация получит новые возможности для обновления своей деятельности и инновационного развития.
Социальное предпринимательство в вузе
Authors: Чернышева Татьяна Леонидовна
Published: December 2017

В статье обосновывается необходимость развития социального предпринимательства в России. Автор констатирует противоречие, нуждающееся в разрешении: в стране, где так много социальных проблем, этот вид деятельности практически не развит. Причина видится в трудно достижимости баланса осуществления социальной цели и получения прибыли: сказывается нехватка финансовых средств из-за налоговой ставки, стоимости страхования, бюрократизация всех процессов. Стратегически важно, по мнению автора, культивировать проекты социального предпринимательства в вузовской среде, поскольку она является колыбелью будущего. Учиться преодолевать преграды следует начинать именно в университетах, которые могут послужить для социальных стартапов бизнес-инкубаторами, особенно это касается опорных региональных вузов, миссией которых является как раз предпринимательство. В статье приводятся меры, которые в силах предпринять вуз для поддержки социального предпринимательства на своей территории, самой первоочередной из которых является создание модели предпринимательского вуза с организационной структурой матричного типа.
О совершенствовании отдельных экономических аспектов институциональной среды кластеров
Authors: Лямзин Олег Леонидович , Выжитович Александр Михайлович
Published: December 2017

В статье исследованы подходы федеральных и региональных органов власти к формированию отдельных элементов институциональной среды для реализации процессов экономической кластеризации. Затронут аспект ускоренного создания требуемой для стимулирования кластеризации экономики, отечественной законодательной базы. Подвергнуты анализу подходы к организации разноуровневой финансовой поддержки формирования территориальных кластеров. Рассмотрены особенности налогообложения и налогового контроля как экономического аспекта институциональной среды кластеров, сформулированы основные проблемы налогообложения и рекомендации по развитию порядка налогообложения юридических лиц в условиях кластера. Проведен анализ нормативной базы в сфере налогообложения, выявлены характерные признаки деятельности участников кластеров с влиянием на налогообложение, предложена упрощенная экономическая модель расчета налога на прибыль при условии выбора участниками кластера консолидированной группы налогоплательщиков, создающая новые основы налоговых взаимоотношений.
Содержание статьи может быть интересно российским и зарубежным специалистам, занимающимся вопросами развития институциональной среды кластеров.
Современные структурные изменения типовых профилей внутреннего турпродукта
Authors: Владыкина Юлия Олеговна , Розумная Наталья Вячеславовна
Published: December 2017

В работе анализируется: формирование спроса на внутренний турпродукт с учетом меняющихся потребительских предпочтений на российском рынке; профиль туриста, влияющий на выбор и структуру основных и дополнительных услуг, а также формат продвижения и реализации внутреннего туристского продукта. Исследования показали, что ослабление потребности в сегменте рекреационного (пляжного) отдыха произошло одновременно с увеличением роли активного, приключенческого и познавательного туризма при одновременном изменении требований к высококачественному многоуровневому сервисному в процессе обслуживания. Анализ особенностей спроса продемонстрировал следующее направления рынка: изменение формата рынка в сторону потребителя «нового типа», неготовность рецессивных туроператоров к массовому обслуживанию, отсутствие целевого спроса и базовых платформ для предложений в неформальном сегменте потребления.
Conhecimento sobre fatores de risco para hipertensão arterial sistêmica por discentes do curso de enfermagem
Authors: Beserra Ayla de Araujo , Silva Luiza Vanessa de Lima , Miranda Emanuel Silva de , Almeida Maria Renata de , Santos Silvana Cavalcanti dos
Published: December 2017

Dentre as doenças crônicas não transmissíveis, a hipertensão arterial sistêmica (HAS) é o maior problema de saúde social dos países desenvolvidos e em muitos dos emergentes. Nesse sentindo, objetivou-se identificar os fatores de risco dos discentes de enfermagem para o desenvolvimento da HAS em um centro de ensino superior de saúde na cidade de Arcoverde, Pernambuco. Trata-se de um estudo de caráter descritivo e exploratório com abordagem quantitativa. A amostra foi composta por 33 discentes, que cursavam o primeiro e o sexto período do curso superior de enfermagem. As variáveis estudadas foram: identificações, socioeconômicos e comportamentais. Em relação ao gênero, dos alunos consultados, apresentaram-se em maior porcentagem os do gênero feminino, informando que fazem uso de bebida alcoólica e apresentam hábitos saudáveis de alimentação. Evidenciou-se à inatividade física, sendo o fator mais citado dos riscos modificáveis, e os antecedentes familiares e a raça, fatores estes intrínsecos não modificáveis. Quanto ao nível de conhecimento sobre a HAS, nos dois períodos, é caracterizado como insuficiente sobre a doença hipertensiva. Torna-se necessário aprofundar alguns conhecimentos sobre HAS dos estudantes e a implementação de orientações sobre a prática de atividade física como um fator preventivo para HAS.
Trabalho de Conclusão de Curso de graduação em saúde: Dificuldades e estratégias
Authors: Mazzoli-Rocha Flavia , Graniço Andrea Serra , Fernandes Alba Barros Souza
Published: December 2017

Objetivou-se descrever dificuldades vivenciadas por professores e pesquisadores diante da elaboração do Trabalho de Conclusão de Curso de Graduação na grande área da Saúde. As estratégias para auxiliar o discente universitário a escrever seu Trabalho de Conclusão de Curso com qualidade técnica, foram pontuadas de forma a auxiliar discentes e orientadores, como fornecer: subsídios para facilitar a escrita da monografia, desde a disponibilização de disciplina de Português à Diretrizes Metodológicas; e informações sobre plágio e seus mecanismos de detecção. A disponibilização destas estratégias pode ser o diferencial na elaboração de um Trabalho de Conclusão de Curso de melhor qualidade.
Avaliação da participação social dos membros do Colegiado territorial das Águas Emendadas
Authors: Dos Santos Neto Alberto Abadia , De Ávila Mário Lúcio
Published: December 2017

A política territorial, adotada a partir do ano de 2003, no Brasil, tem uma trajetória que instiga inúmeras pesquisas e debates no cenário das instituições de ensino que atuam com foco no desenvolvimento rural, há consensos de que são necessários inúmeros ajustes da política. Entretanto, é preciso conhecer mais sobre a dinâmica de cada território e elaborar estudos que possam fornecer, com mais clareza, informações das especificidades territoriais do país. Logo, esse estudo tem o objetivo de caracterizar a participação social no território das Águas Emendadas. Os resultados foram obtidos, com a análise de dados e informações coletados nos espaços coletivos do Colegiado, por meio de entrevistas, aplicação de questionários e observações participativas. A maneira como o território vem se constituindo, apresenta divergências de interesses não territorialmente pensados, não há consensos e as identidades são limitadas entre as instituições dos estados (MG e GO) e o Distrito Federal.
Gestão participativa do colegiado territorial Sertão São Francisco - Pernambuco
Authors: Silva Flaviane Maria Florêncio Monteiro , Amorim Danielle Morais , Assis Filho Francisco , Nunes Xenusa Pereira , Carvalho Lígia , Amorim Ruth Morais N , Oliveira Lúcia Marisy Souza Ribeiro
Published: December 2017

Os Colegiados Territoriais (CODETERs), são importantes espaços políticos de decisão participativa das organizações sociais vinculadas ao processo desenvolvimento rural sustentável do Brasil. Nesse espaço pode-se realizar discussão, planejamento, controle social, deliberação de ações do território relacionado à infraestrutura, educação, cultura, saúde, produção agrícola e animal, contribuindo com o desenvolvimento sustentável da região. Objetivando analisar a participação social do Colegiado Territorial Sertão São Francisco-PE (COSERFRAN-PE) e a contribuição deste território no desenvolvimento rural da região, foi realizada uma pesquisa sobre gestão social/participativa dos CODETERs, dando-se ênfase na pesquisa documental da gestão social do COSERFRAN-PE. Com base nesta análise de dados, constatou-se uma pequena representação, no COSERFRAN-PE, da sociedade civil organizada por município, como também uma baixa representação e participação do poder público nas plenárias. Essa baixa representatividade impacta, negativamente, na tomada de decisões e deliberações, dificultando uma plena gestão participativa e desenvolvimento significativo do Território.