bluuebunny/crossref_metadata_2025 huggingface dataset:
Sterility release testing of peripheral blood stem cells for transplantation: impact of culture bottles and incubation temperature
Authors: Arlt Nicole , Rothe Remo , Sielaff Susann , Juretzek Thomas , Peltroche Heidrun , Moog Rainer
Published: September 2018

BACKGROUND

Sterility testing of peripheral blood stem cells (PBSCs) is mandatory before release. As antibiotic treatment of the PBSC donor may result in false‐negative results, PBSC matrix validation must be carried out.

STUDY DESIGN AND METHODS

Three spiked PBSCs and a buffy coat (BC; control matrix) were analyzed using the blood culture device BacT/ALERT 3D with the low‐temperature module. Samples were spiked with Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, Candida albicans, Aspergillus brasiliensis, Clostridium sporogenes, and Propionibacterium acnes. Standard iAST/iNST culture bottles and iFA/iFN Plus bottles, which include resorbing polymers, were incubated for 14 days. All aerobic bottles were incubated at 22.5°C and for a direct comparison also at 35°C while all anaerobic bottles were incubated at 35°C.

RESULTS

The BacT/ALERT 3D system detected all microbes in iAST/iNST culture bottles according to their growth behavior in the BC matrix. Detection of microbes differed significantly in PBSC products using standard iAST/iNST culture bottles and iFA/iFN Plus bottles with resorbing polymers: In Graft 1 no growth was detected in spiked bottles with S. aureus (iAST), B. subtilis (iAST/iNST), C. sporogenes (iNST), and P. acnes (iNST) compared to iFA Plus and iFN Plus bottles wherein growth of spiked microbes was confirmed. Graft 2, with another antibiotic treatment, showed no growth in iAST/iNST bottles spiked with P. aeruginosa, B. subtilis, and C. sporogenes. However, using iFA/iFN Plus bottles all spiked microbes were detectable. The comparison of incubation temperature showed an expected slower growth at 22.5°C.

CONCLUSION

The use of iFA/iFN Plus culture bottles incubated at different temperatures safely detected microbes in spiked PBSCs.
Transfusion‐transmitted babesiosis: one state's experience
Authors: Klevens R. Monina , Cumming Melissa A. , Caten Evan , Stramer Susan L. , Townsend Rebecca L. , Tonnetti Laura , Rios Jorge , Young Carolyn T. , Soliva Susan , DeMaria Alfred
Published: September 2018

BACKGROUND

The risk for tickborne exposure to Babesia microti infection exists statewide in Massachusetts. Broad exposure complicates investigations of transfusion‐transmitted babesiosis (TTB). We summarize 8 years of the epidemiology of TTB and highlight the role of public health in prevention and control.

STUDY DESIGN AND METHODS

Cases of babesiosis are routinely reported to the Massachusetts Department of Public Health. These are investigated to determine whether they meet the surveillance case definition and to identify whether they were potentially transfusion transmitted. Frequencies from 2009 to 2016 are described and incidence rates calculated using population denominators from the US census. Changes over time were analyzed using simple linear regression.

RESULTS

From 2009 to 2016, there were 2578 cases of babesiosis reported; of these, 45 (1.7%) were transfusion transmitted. Of the 45 cases of TTB, 15 (33%) received blood products from two or more suppliers. In 11 TTB cases, the Department of Public Health was notified first, who in turn notified the appropriate blood provider. In 2009, the crude rate of reported babesiosis was 1.2 per 100,000 population and increased significantly through 2016 to 7.8 per 100,000 population (p = 0.006). The number of blood donors reported with laboratory evidence of B. microti infection increased from 19 in 2012 to 78 in 2016; at the same time, the number of TTB cases decreased from six to three.

CONCLUSION

TTB remains a major challenge, and blood donor screening strategies are currently in the process of implementation. While population and environmental changes facilitate increases in babesiosis, donor screening has the potential to eliminate TTB.
Noninvasive prenatal HPA‐1 typing in HPA‐1a negative pregnancies selected in the Polish PREVFNAIT screening program
Authors: Orzińska Agnieszka , Guz Katarzyna , Uhrynowska Małgorzata , Dębska Marzena , Mikula Michal , Ostrowski Jerzy , Ahlen Maria Therese , Husebekk Anne , Brojer Ewa
Published: September 2018

BACKGROUND

Anti‐HPA‐1a alloantibodies in HPA‐1a negative mothers can lead to fetal/neonatal alloimmune thrombocytopenia (FNAIT). Noninvasive prenatal testing (NIPT) of HPA‐1a determines fetuses at risk and the course of maternal antenatal treatment.

STUDY DESIGN AND METHODS

The aim was to develop and validate HPA‐1a NIPT by real‐time polymerase chain reaction (PCR) or next‐generation sequencing (NGS) for a high‐throughput screening setting. DNA from 328 plasma samples of 299 HPA‐1a negative pregnant women was examined for HPA‐1a by real‐time PCR and in two cases also by NGS (Ion Torrent). The results were compared with neonatal HPA‐1a genotyping in 281 cases.

RESULTS

HPA‐1a NIPT was negative in 44 of 51 HPA‐1a negative fetuses, inconclusive in five, and false positive in two. In 228 of 229 HPA‐1a positive fetuses, the NIPT results were positive (mean threshold cycle 36.0 ± 1.7) and inconclusive in one. In 22 cases with HPA‐1a positive fetuses analyzed twice, the sensitivity of HPA‐1a detection was significantly higher at 28 weeks compared with 16 to 20 weeks. NGS efficiently detected the ITGB3 coding HPA‐1a/b (1% and 5% fetal HPA‐1a reads).

CONCLUSION

Real‐time PCR is reliable to predict the fetal HPA‐1a positive genotype in a screening study, but false‐positive results are reported in 4%, with unnecessary prenatal treatment if anti‐HPA‐1a is detected.
WTO trade policy review for Switzerland: In need for a new paradigm
Authors: Weder Rolf
Published: September 2018

This paper argues that the World Trade Organization (WTO) and one of its important instruments, Trade Policy Review (TPR), should refocus on what they were created for: trade policy. This strategy is shown to be well‐founded in international trade theory. In contrast, the TPR 2017 on Switzerland and Liechtenstein deals with a large number of policies that are not or only indirectly related to international trade, but lie at the core of a country's self‐identification and sovereignty. It is concluded that the world trade system would gain in political support and thus benefit if countries were limited in their interference at the border, but enjoyed more freedom in their national policies.
Reviewer Acknowledgements
Authors: Young James
Published: September 2018

International Journal of Social Science Studies (IJSSS) would like to acknowledge the following reviewers for their assistance with peer review of manuscripts for this issue. Many authors, regardless of whether IJSSS publishes their work, appreciate the helpful feedback provided by the reviewers. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Each of the reviewers listed below returned at least one review for this issue. Reviewers for Volume 6, Number 10Agboola O. Paul, Universiti Teknologi Malaysia, MalaysiaAhmet Yıkmış, Abant Izzet Baysal Univeersity, TurkeyAmir Hossain, IBAIS University, BangladeshFroilan Mobo, Philippine Merchant Marine Academy, PhilippinesHenry Poduthas, West Texas A&M University, USAJihyoung Kim, Pyeongtaek University, South KoreaJulia M. Mack, Gannon University, USAMarja Känsälä, Finnish Institute of Occupational Health, FinlandMiriam Parise, Università Cattolica del Sacro Cuore, ItalyOzgur Demirtas, Inonu University, TurkeyPaula Hanasz, Australian National University, AustraliaShariq aziz butt, Superior University Lahore, PakistanSudershan Pasupuleti, The University of Texas, USA  James YoungEditorial AssistantOn behalf of,The Editorial Board of International Journal of Social Science StudiesRedfame Publishing9450 SW Gemini Dr. #99416Beaverton, OR 97008, USAURL: http://ijsss.redfame.com
Comparison of traditional 2D and 3D Omniview technique in detection of fetus corpus callosum
Authors: Li Yang , Tao Guo-wei , Pan Ming-zhi , Shao Guang-rui
Published: September 2018

Aim: To explore the value of Omniview (OV) technology in assessing the fetus corpus callosum.Material and methods: For the ultrasound examination of 189 fetuses (gestational week range 19-28 weeks), two-dimensional (2D) ultrasound imaging and Omniview technology were used by two physicians (A and B). The acquisition time and the quality of images were recorded.Results: The acquisition time of Omniview technology was shorter comparing with the aquisition time of 2D ultrasound imaging (A2D vs. AOV: 159.44±27.09 s vs. 73.90±18.99 s, p<0.01; B2D vs. BOV: 120.22±21.89 s vs. 74.19±14.86 seconds, p<0.01). 2D ultrasound examination was performed in a longer time by the junior physician, compared with the senior physician (A2D vs. B2D: 159.44±27.09 s vs. 120.22±21.89 s, p<0.01). The intra- and inter-observer reliability of acquisition time using Omniviewtechnology was good (LoA: ‒11.8 to +12.4s, and ‒41.9 to +43.3s, respectively). The success rate of junior and senior physicians with the Omniview technique was 76.2% and 80.4%, respectively. There was good consistency between the Omniview technique and 2D ultrasound imaging in terms of image quality (Kappa = 0.782, 95% CI: 0.586-0.977).Conclusion: Omniview technique can not only obtain corpus callosum images more effectively but also can achieve better quality images. Therefore, it is a reliable method to image the fetal corpus callosum.
Ecology and biology of Hydrozetes paulista (Acari: Oribatida) in the benthic zone of a temporary lake in Brazil
Authors: Seniczak Anna , Seniczak Stanisław , Sant'anna Eneida M. Eskinazi , Dias Emerson , Graczyk Radomir , Słowikowska Mariola
Published: September 2018

Oribatid mites are mainly terrestrial animals, but some are aquatic, including all species of the genus Hydrozetes (Hydrozetidae). They have often been recorded in abundance on the water’s surface, while their presence in the benthic zone is poorly documented. A litterbag experiment was carried out in Coutos Lake, a shallow temporary lake in Southeast Brazil, in order to study the ecology and biology of Hydrozetes paulista. This mite species greatly dominated the benthic invertebrate community (82%), and at the end of the experiment it reached a density (652 individuals per 1 g of dry substrate) higher than that ever previously reported before for any Hydrozetes species. This density was correlated with some water parameters, stronger with conductivity, and less with temperature. The adults dominated in the stage structure (constituting over 80% of sample population), but the participation of the juveniles increased with the time. Larvae were first noticed on 25th day of experiment and after that were present for the rest of the season. During the course of this experiment, mite fecundity and body size decreased. This species is known as bisexual, but we observed only females in the 5354 adults we collected.
Williams syndrome with severe hypercalcaemia
Authors: Gupta Vishal , Pandita Aakash , Panghal Astha , Kallem Venkat Reddy
Published: September 2018

We present an 11-month-old girl child with complaints of constipation, cough, fever, vomiting and growth retardation. On examination, she had facial dysmorphism, hypertension and murmur. The genetic evaluation showed 7q microdeletion specific to Williams syndrome. Abdominal imaging was suggestive of nephrocalcinosis which is rare for this age group. The baby was managed symptomatically and specific treatment like pamidronate, calcitonin and steroid therapy were also administered to reduce hypercalcaemia. Severe hypercalcaemia with associated hypertension and nephrocalcinosis is very rare. Hence, we emphasise here the importance of early detection of these features and their appropriate management for a better outcome of the patient.
Recurrent aseptic meningitis with PIGT mutations: a novel pathogenesis of recurrent meningitis successfully treated by eculizumab
Authors: Kawamoto Michi , Murakami Yoshiko , Kinoshita Taroh , Kohara Nobuo
Published: September 2018

We report the case of a patient with PIGT mutations who experienced recurrent aseptic meningitis 121 times over 16 years before developing paroxysmal nocturnal haemoglobinuria (PNH). Each episode was preceded by urticaria and arthralgia. After developing PNH, haemolysis occurred prior to meningitis. Flow cytometry revealed deficiency of the glycophosphatidylinositol (GPI)-anchored complement regulatory proteins, CD59 and CD55, and he was diagnosed with PNH. All the symptoms disappeared on administering eculizumab, an anti-C5 antibody. We did not detect mutation in PIGA, which is regarded as the cause of PNH. However, we detected a germ-line mutation and a somatic microdeletion in chromosome 20q including PIGT; PIGT is essential for transferring GPI anchor to the precursors of CD59 and CD55, which play important roles in complement regulation. Loss of these proteins leads to complement overactivation, causing inflammatory symptoms, including recurrent meningitis. PIGT mutations should be considered a novel pathogenesis of recurrent meningitis of unknown aetiology.
First-in-man experience of the Versi Retriever in acute ischemic stroke
Authors: Sakai Nobuyuki , Imamura Hirotoshi , Adachi Hidemitsu , Tani Shoichi , Tokunaga So , Funatsu Takayuki , Suzuki Keita , Adachi Hiromasa , Sasaki Natsuhi , Kawabata Shuhei , Akiyama Ryo , Horiuchi Kazufumi , Ohara Nobuyuki , Kono Tomoyuki , Fujiwara Satoru , Kaneko Naoki , Tateshima Satoshi
Published: September 2018

Objective

To describe our initial experience with the Versi Retriever for mechanical thrombectomy in patients with acute ischemic stroke.

Methods

This study is a single-center, single-arm, first-in-man registry under institutional review board control to evaluate the efficacy and safety of the new stent retriever, the Versi Retriever. Patients with acute ischemic stroke were consecutively enrolled between September and November 2017. The clinical and procedural data were retrospectively analyzed. The angiographic result after the procedure was self-graded based on the Thrombolysis in Cerebral Infarction (TICI) scale by each operator.

Results

Eleven patients with a mean age of 69.4 years were treated with the Versi Retriever. Median National Institutes of Health Stroke Scale score on admission was 16 (IQR 10–34). The occluded vessel was located in the anterior circulation in 81.8%. Revascularization rates of TICI 2b–3 and TICI 3 at final angiogram were achieved in 100% and 63.6%, respectively. A favorable functional outcome (modified Rankin Scale 0–2) at 90 days was obtained in 72.7%. No symptomatic intracranial hemorrhage occurred and no procedure-related complication was observed.

Conclusions

Our initial experience suggests that the Versi Retriever is a safe and effective stent retriever for mechanical thrombectomy in patients with acute ischemic stroke.

Clinical trial registration

NCT03366818
Treatment of intracranial aneurysms using the pipeline flex embolization device with shield technology: angiographic and safety outcomes at 1-year follow-up
Authors: Martínez-Galdámez Mario , Lamin Saleh M , Lagios Konstantinos G , Liebig Thomas , Ciceri Elisa F , Chapot Rene , Stockx Luc , Chavda Swarupsinh , Kabbasch Christoph , Faragò Giuseppe , Nordmeyer Hannes , Boulanger Thierry , Piano Mariangela , Boccardi Edoardo P
Published: September 2018

Purpose

The Pipeline Embolization Device (PED) is a routine first-line treatment option for intracranial aneurysms (IAs). The Pipeline Flex Embolization Device with Shield Technology (Pipeline Shield) is an updated version of the PED which has been modified to include a surface phosphorylcholine biocompatible polymer. Its early technical success and safety have been reported previously. Here, we assessed the long-term safety and efficacy of the Pipeline Shield for the treatment of IAs.

Materials and methods

The Pipeline Flex Embolization Device with Shield Technology (PFLEX) study was a prospective, single-arm, multicenter study for the treatment of unruptured IAs using the Pipeline Shield. The primary endpoint was a major stroke in the territory supplied by the treated artery or neurologic death at 1-year post-procedure. Angiographic outcomes were also assessed by an independent radiology laboratory at 6 months and 1 year.

Results

Fifty patients (mean age, 53 years; 82% female) with 50 unruptured IAs were treated. Mean aneurysm diameter was 8.82±6.15 mm. Of the target aneurysms, 38/50 (76%) were small (<10 mm), 11/50 (22%) were large (≥10 and<25 mm), and 1/50 (2%) was giant (≥25 mm). Forty-seven (94%) were located in the internal carotid artery and three (6%) in the vertebral artery. At 1-year post-procedure, no major strokes or neurologic deaths were reported, and complete occlusion was achieved in 27/33 (81.8%). There were no instances of aneurysm recurrence or retreatment.

Conclusions

Our 1-year follow-up concerning angiographic and safety outcomes corroborate previous evidence that the Pipeline Shield is a safe and effective treatment for IAs.

Trial registration number

NCT02390037
Effective stress regime around a jacked steel pile during installation ageing and load testing in chalk
Authors: Buckley R.M. , Jardine R.J. , Kontoe S. , Lehane B.M.
Published: September 2018

This paper reports experiments with 102 mm diameter closed-ended instrumented Imperial College piles (ICPs) jacked into low- to medium-density chalk at a well-characterized UK test site. The “ICP” instruments allowed the effective stress regime surrounding the pile shaft to be tracked during pile installation, equalization periods of up to 2.5 months, and load testing under static tension and one-way axial cyclic loading. Installation resistances are shown to be dominated by the pile tip loads. Low installation shaft stresses and radial effective stresses were measured that correlated with local cone penetration test (CPT) tip resistances. Marked shaft total stress reductions and steep stress gradients are demonstrated in the vicinity of the pile tip. The local interface shaft effective stress paths developed during static and cyclic loading displayed trends that resemble those seen in comparable tests in sands. Shaft failure followed the Coulomb law and constrained interface dilation was apparent as the pile experienced drained loading to failure, although with a lesser degree of radial expansion than with sands. Radial effective stresses were also found to fall with time after installation, leading to reductions in shaft capacity as proven by subsequent static tension testing. The jacked, closed-ended, piles’ ageing trends contrast sharply with those found with open piles driven at the same site, indicating that ageing is affected by pile tip geometry and (or) installation method.
Effect of Ni concentration on optical properties of rocksalt CdS system (A DFT + U study)
Authors: Junaid Iqbal Khan M. , Kanwal Zarfishan , Nauman Usmani M. , Yousef Masood , Akhtar Perveen , Nabi Azeem
Published: September 2018

Present study is a computational approach focused on optical properties of Ni-doped rocksalt CdS system under PBE-GGA and GGA + U approximations. Investigation of optical properties of CdS:Ni system by fixing supercell size and increasing dopant concentration is a focus of study. Cd atoms are substituted by Ni atoms and optical properties show significant change for higher Ni concentration. Redshift in optical absorption is observed as dopant concentration is increased. Interaction of Ni and S atoms and localization of d-states are inspected near the conduction band minima or Fermi surface. GGA + U absorption plots show slight variation with increase in energy values. Ni-doping in CdS host lattice enhances its opto-electronic properties which extend its applications in optical sensors, optical and similar devices.
Hybrid radial plate-type elastic metamaterials for lowering and widening acoustic bandgaps
Authors: Li Yinggang , Zhou Qingwen , Zhu Ling , Guo Kailing
Published: September 2018

In this paper, we present theoretical investigation on the wave propagation and acoustic bandgap characteristics in hybrid radial plate-type elastic metamaterials constituted of periodic double-sides composite stubs deposited on one-dimensional binary radial phononic crystal plate. The dispersion relations and the displacement fields of the eigenmodes are calculated by using the finite element method on the basis of two-dimensional axial symmetry models. Numerical results show that the proposed hybrid radial plate-type elastic metamaterial can generate lowering and widening acoustic bandgaps and yield a significant expansion of the relative bandwidth by a factor of 5 compared to the traditional radial plate-type elastic metamaterial with double-sided composite stubs. The displacement fields of the eigenmodes are applied to reveal the formation mechanism of lowering and widening acoustic bandgaps. In addition, the influences of the physical and geometrical parameters on the bandgaps are further performed. These low-frequency broadband acoustic bandgap properties in the radial plate-type elastic metamaterials can probably be applied to vibration and noise reduction in the rotary machines and structures.
Comparative study of magneto-transport and lattice-vibrational properties of La2/3Ca1/3MnO3 thin films grown on SrTiO3 and LaAlO3 substrates
Authors: Xie Qiyun , Zhou Xuran , Qi Chao , Bai Gang , Chen Limin , Cheng Guofeng
Published: September 2018

Epitaxial La[Formula: see text]Ca[Formula: see text]MnO3 (LCMO) thin films of 60 nm are deposited on (001)-oriented SrTiO3 (STO) and LaAlO3 (LAO) substrate by modified off-axis magnetron sputtering method. The strain state of the films have been studied by high resolution X-ray diffraction. The magneto-transport properties were found to be strongly dependent on the substrate used. Compared with LCMO/LAO film (compressive strain), LCMO/STO film with tensile strain exhibits lower metal-insulator transition temperature, suppressed Curie temperature, higher resistivity and more localization of electron. The evolution of the Raman modes has also been investigated. The vibrational mode of LCMO/LAO is comparable to the bulk, while the signature of vibration mode at about 610 cm[Formula: see text] induced by strain-related distortion has been observed only in tensile strained LCMO/STO case. The controversial 660 cm[Formula: see text] peak is not observed in our films, which precludes the possible existence of Mn3O4 precipitates in the films.
Sonic horizon formation for coupled one-dimensional Bose–Einstein condensate in an elongated harmonic potential
Authors: Wang Ying , Zhou Shuyu
Published: September 2018

We theoretically studied the sonic horizon formation problem for coupled one-dimensional Bose–Einstein condensate trapped in an external elongated harmonic potential. Based on the coupled (1[Formula: see text]+[Formula: see text]1)-dimensional Gross–Pitaevskii equation and F-expansion method under Thomas–Fermi formulation, we derived analytical wave functions of a two-component system, from which the sonic horizon’s occurrence criteria and location were derived and graphically demonstrated. The theoretically derived results of sonic horizon formation agree pretty well with that from the numerically calculated values.
Systems Pharmacology: Defining the Interactions of Drug Combinations
Authors: van Hasselt J.G. Coen , Iyengar Ravi
Published: September 2018

The majority of diseases are associated with alterations in multiple molecular pathways and complex interactions at the cellular and organ levels. Single-target monotherapies therefore have intrinsic limitations with respect to their maximum therapeutic benefits. The potential of combination drug therapies has received interest for the treatment of many diseases and is well established in some areas, such as oncology. Combination drug treatments may allow us to identify synergistic drug effects, reduce adverse drug reactions, and address variability in disease characteristics between patients. Identification of combination therapies remains challenging. We discuss current state-of-the-art systems pharmacology approaches to enable rational identification of combination therapies. These approaches, which include characterization of mechanisms of disease and drug action at a systems level, can enable understanding of drug interactions at the molecular, cellular, physiological, and organismal levels. Such multiscale understanding can enable precision medicine by promoting the rational development of combination therapy at the level of individual patients for many diseases.
Positive Affect and Health: What Do We Know and Where Next Should We Go?
Authors: Pressman Sarah D. , Jenkins Brooke N. , Moskowitz Judith T.
Published: September 2018

Positive affect (PA) is associated with better health across a wide range of physical health outcomes. This review reflects on why the study of PA is an essential component of our understanding of physical health and expands on pathways that connect these two variables. To encourage forward movement in this burgeoning research area, measurement and design issues in the study of PA and health are discussed, as are the connections between PA and a range of different health outcomes. Plausible biological, social, and behavioral pathways that allow for positive feelings to get under the skin and influence physical wellness are detailed and framed in the context of several theoretical models. Finally, new directions for the field and important methodological and interpretative considerations that are essential to moving this important research area forward are explored.
A Biological Model for Resource Allocation and User Dynamics in Virtualized HetNet
Authors: Ma Lu , Wen Xiangming , Wang Luhan , Lu Zhaoming , Knopp Raymond , Ghauri Irfan
Published: September 2018

Virtualization technology is considered an effective measure to enhance resource utilization and interference management via radio resource abstraction in heterogeneous networks (HetNet). The critical challenge in wireless virtualization is virtual resource allocation on which substantial works have been done. However, most existing researches on virtual resource allocation focus on improving total utility. Different from the existing works, we investigate the dynamic‐aware virtual radio resource allocation in virtualization based HetNet considering utility and fairness. A virtual radio resource management framework is proposed, where the radio resources of different physical networks are virtualized into a virtual resource pool and mobile virtual network operators (MVNOs) compete for virtual resources from the pool to provide service to users. A virtual radio resource allocation algorithm based on biological model is developed, considering system utility, fairness, and dynamics. Simulation results are provided to verify that the proposed virtual resource allocation algorithm not only converges within a few iterations, but also achieves a better trade‐off between total utility and fairness than existing algorithm. Besides, it can also be utilized to analyze the population dynamics of system.
Functional and Structural Outcomes of Temporal Zone II-Sparing Laser Photocoagulation Combined with Intravitreal Bevacizumab in Retinopathy of Prematurity
Authors: Seo Eoi Jong , Lee Joo Yong
Published: September 2018

Background/Aim. The aim of the study was to investigate the outcomes of temporal Zone II-sparing laser photocoagulation combined with intravitreal bevacizumab (IVB) in patients with Type 1 retinopathy of prematurity (ROP) in Zone I.Methods. Medical records of 74 eyes of 37 infants were analysed. Only infants with Type 1 ROP in Zone I were included. Thirty-two eyes were treated with temporal-sparing laser + IVB. Both Zone I and temporal Zone II were spared to minimise potential visual field loss. Forty-two eyes were treated with laser alone conventionally. Early treatment outcomes, late complications, and refractive errors were analysed.Results. The mean gestational age and birth weight of the enrolled patients were 25.7 ± 2.5 weeks and 798.8 ± 440.2 g, respectively. In the combined treatment group, plus sign regression was achieved faster (12.1 ± 6.2 days vs. 25.6 ± 21.3 days,p=0.011) and retreatment was required less (0% vs. 23.8%,p=0.004) than in the laser-alone group. Retinal/preretinal haemorrhages occurred more often in the laser-alone group (42.9% vs. 9.4%,p=0.002). Normal development of temporal retinal vessels was also observed in twelve eyes in the combined treatment group. No differences in late complications or refractive errors were observed between the groups.Conclusion. Temporal Zone II-sparing laser treatment combined with IVB showed good early treatment outcome and temporal retinal vessels development.
Effect of Dietary Selenium on Protein and Lipid Oxidation and the Antioxidative Potential of Selected Chicken Culinary Parts during Frozen Storage
Authors: Korzeniowska Małgorzata , Króliczewska Bożena , Kopeć Wiesław
Published: September 2018

The objective of the study was to evaluate the effects of inorganic and organic selenium in the diet of broiler chickens on the oxidative changes in the functional groups of proteins and total lipids, as well as the antioxidative potential of typical culinary parts fresh and frozen. Materials used in the nutrition study comprises one-day-old Flex broiler chickens randomly allocated to three dietary treatments: Control and SeN-fed diet enriched with 0.50 mg/kg of inorganic selenium (sodium selenite), and SeO-fed with diet containing 0.50 mg/kg of selenized yeast Yarrowia lipolytica. After slaughter, chicken carcasses were divided into the most typical culinary parts i.e., wings, outer and deep breasts, drumstick, thigh and back and analyzed in the fresh state and during frozen storage at −18°C until 90 days. The analyses undertaken during the study measured selenium concentration, CO, SH, and NH2 groups in the proteins, TBARS-expressing changes in the lipids, and antioxidative potential by ABTS, DPPH, and FRAP methods. The results of the study showed that the dietary selenium supplementation effectively increased the selenium concentration in all analyzed culinary parts of the chicken carcass, especially high in leg muscles. Selenium supplementation of the chicken diet significantly reduced the oxidative changes in the most important chemical reactive groups of the muscle myofibrillar proteins in all analyzed culinary parts. Both forms of selenium, organic and inorganic, were able to slow down the oxidation processes during first 30 days of the frozen storage of the meat. Longer storage could be only recommended for breast fillets, definitely not for the back part. The effect was much stronger in case of an organic selenium supplementation comparing to inorganic form of diet enrichment.
Iterative Intercell Interference Cancellation in MIMO Multicell Networks
Authors: Zhang Zhengzhen , Dong Chao , Wan Qian
Published: September 2018

An iterative intercell interference cancellation algorithm is introduced to improve the receiver performance of uplink transmission in multicell networks. At first, the uplink signal detection is performed independently in each cell according to minimum mean squared error (MMSE) criterion. Subsequently, the detection results are applied to reconstruct the transmit signals of different users and cancel their interference to neighboring cells. With the help of reconstruction results, the MMSE detection matrix of each cell is updated. The channel responses of both efficient and interference links are estimated with the help of pilots. The pilot allocation parameter is introduced to indicate the quality of channel estimation. The simulation results indicate that intercell interference can be greatly mitigated by the proposed algorithm with a moderate number of receiver antennas at the base station.
Optimization of Classification Track Assignment Considering Block Sequence at Train Marshaling Yard
Authors: Zhang Yingqun , Song Rui , He Shiwei , Li Haodong , Guo Xiaole
Published: September 2018

An operational process at train marshaling yard is considered in this study. The inbound trains are decoupled and disassembled into individual railcars, which are then moved to a series of classification tracks, forming outbound trains after being assembled and coupled. We focus on the allocation plan of the classification tracks. Given are the disassembling and assembling sequence, the railcars connection plan, and a number of classification tracks. Output is the assignment of the railcars to the classification tracks. An integer programming model is proposed, aimed at reducing the number of coupling operations, as well as the number of dirty tracks which is related to the rehumping operation, and the order of the railcars on the outbound train must satisfy the block sequence. Tabu algorithm is designed to solve the problem, and the model is also tested by CPLEX in comparison. A numerical experiment based on a real-world case is analyzed, and the result can be reached within a reasonable amount of time. We also discussed a number of factors that may affect the track assignment and gave suggestions for the real-world case.
Anti-Double-Stranded DNA Isotypes and Anti-C1q Antibody Improve the Diagnostic Specificity of Systemic Lupus Erythematosus
Authors: Jia Yu , Zhao Lingling , Wang Chunyan , Shang Jin , Miao Yi , Dong Yangyang , Zhao Zhanzheng
Published: September 2018

Objectives. We aimed to evaluate the value of immunoglobulin (Ig) G, IgM, and IgA isotypes of anti-double-stranded DNA (anti-dsDNA) and anti-C1q antibody in diagnosing systemic lupus erythematosus (SLE) patients and elucidate their association with disease activity and lupus nephritis.Methods. Blood samples were obtained from 96 SLE patients, 62 other autoimmune disease patients, and 60 healthy blood donors. Anti-dsDNA IgG, IgM, and IgA isotypes and anti-C1q antibody were measured by enzyme-linked immunosorbent assay. Disease activity of SLE patients was assessed according to the SLE Disease Activity Index score.Results. When specificity was greater than 90%, the sensitivity of anti-dsDNA IgG, IgM, and IgA isotypes and anti-C1q antibody in diagnosing SLE was 75%, 45%, 33%, and 49%, respectively. The prevalence of anti-dsDNA IgG (p=0.002), anti-dsDNA IgA (p=0.028), and anti-C1q antibody (p=0.000) in active cases was significantly higher than those in inactive ones. In addition, the presence of anti-C1q antibody was associated with renal involvement (p=0.032). Anti-dsDNA IgM showed no significant association with disease activity, but it was inversely linked with lupus nephritis (p=0.005). When anti-dsDNA IgG and IgA and anti-C1q were combined to evaluate SLE disease activity, the specificity reached the highest level (90%). When anti-C1q positive was accompanied by anti-dsDNA IgM negative, the specificity of diagnosing lupus nephritis was up to 96%.Conclusions. This study demonstrated the role of anti-dsDNA IgG, IgM, and IgA isotypes and anti-C1q antibody alone or combination in diagnosing SLE. Anti-dsDNA IgG and IgA and anti-C1q were shown to be associated with disease activity, while anti-dsDNA IgM and anti-C1q were associated with lupus nephritis. When the related antibodies were combined, the diagnostic specificity was significantly higher.
Comparison of the Clinical Performance of Refractive Rotationally Asymmetric Multifocal IOLs with Other Types of IOLs: A Meta-Analysis
Authors: Xu Zequan , Li Wenzhe , Wu Lianqun , Xue Shuang , Chen Xu , Wu Qiang
Published: September 2018

Objective. To compare the clinical performance of refractive rotationally asymmetric multifocal intraocular lens (IOLs) with spherical monofocal, accommodating, and bifocal IOLs. Methods. A comprehensive literature search of PubMed, EMBASE, Cochrane Controlled Trials Register, and Web of Science up to February 2017 was performed to identify randomized controlled trials (RCT) and comparative cohort studies. Main outcomes were uncorrected distance visual acuity (UDVA), uncorrected intermediate visual acuity (UIVA), uncorrected near visual acuity (UNVA), higher-order aberrations (HOAs), MTF, Strehl ratio, and residual sphere and cylinder. Results. Mplus provided significantly worse UDVA than spherical monofocal IOLs (WMD: 0.13, P=0.008), but significantly better UIVA than high-add bifocal IOLs (WMD: −0.19, P<0.00001), spherical monofocal IOLs (WMD: −0.12, P<0.0001), and accommodating IOLs (WMD: −0.21, P<0.00001). Mplus provided significantly worse UNVA than high-add bifocal IOLs (WMD: 0.07, P<0.00001), but significantly better UNVA than spherical monofocal IOLs (WMD: −0.19, P<0.00001). Mplus resulted in significantly higher HOAs than high-add bifocal IOLs (WMD: 0.38, P<0.00001) and spherical monofocal IOLs (WMD: 0.51, P=0.0004). Mplus provided a significantly lower MTF cut-off and Strehl ratio than other type of IOLs. Conclusion. The Mplus IOLs perform best regarding intermediate visual acuity whereas they lack in distance visual acuity compared to monofocal IOLs and near visual acuity compared to bifocal IOLs. These results may be due to structure of Mplus IOLs resulting in higher-order aberrations.
A Novel “Slit Side View” Method to Evaluate Fluid Dynamics during Phacoemulsification
Authors: Suzuki Hisaharu , Igarashi Tsutomu , Shiwa Toshihiko , Takahashi Hiroshi
Published: September 2018

Due to recent technical advances in cataract surgeries, there has been a significant improvement in the safety and surgical outcomes of phacoemulsification. However, the corneal endothelium can be damaged during phacoemulsification by multiple factors. Therefore, we used a slit lamp to analyze the fluid dynamics of ophthalmic viscosurgical devices (OVDs) in the anterior chamber during phacoemulsification. In this experimental study, extracted porcine eyes were injected with OVDs stained with fluorescein through a side port of the eye and then fixed on a slit lamp microscope. After inserting a phaco tip, phacoemulsification simulation was then performed on the iris plane. Subsequent movements of OVDs in the anterior chamber were observed during the procedure by using a slit lamp microscope. Aspiration and removal of cohesive OVDs from the inside of the anterior chamber occurred within a few seconds after the ultrasonic vibration. Aspiration of dispersive OVDs occurred gradually, with some of the OVDs remaining on the side of the anterior chamber side in an irregular shape. This shape enabled the OVD to trap the air, thereby preventing the air from directly touching the corneal endothelium. Viscoadaptive OVDs remained inside the anterior chamber as a lump, with the infusion solution flowing between the corneal endothelium and the OVD, thus leading to the eventual aspiration of the OVD. Viscous dispersive OVDs remained as a lump between the corneal endothelium and the phaco tip. However, once the infusion solution flowed between the cornea and the OVD, the OVD detached from the corneal endothelium, indicating that this type would likely be aspirated and removed. This method, termed the “slit side view,” enables viewing of the movement of OVDs during surgery, as well as observation of the fluid dynamics in the anterior chamber.
Splenic B-Cell Lymphomas with Diffuse Cyclin D1 Protein Expression and Increased Prolymphocytic Cells: A Previously Unrecognized Diagnostic Pitfall
Authors: Algashaamy Khaled , Tan Yaohong , Mackrides Nicolas , Alencar Alvaro , Peng Jing-Hong , Rosenblatt Joseph , Alderuccio Juan P , Lossos Izidore S. , Vega Francisco , Chapman Jennifer
Published: September 2018

Prolymphocytic transformation is a concept usually applied in the context of chronic lymphocytic leukemia/small lymphocytic lymphoma to describe the presence of a high percentage of prolymphocytes in peripheral blood (usually more than 55%). Prolymphocytic transformation has also been reported in mantle cell lymphoma (MCL) but only rarely in splenic marginal zone lymphoma (SMZL). We present two splenic B-cell lymphomas presenting in the leukemic phase and with increased prolymphocytes, both classified as SMZL with prolymphocytic transformation. One case clinically simulated B-prolymphocytic leukemia (B-PLL). Both lymphomas were very unusual because the tumor cells diffusely and strongly expressed cyclin D1 despite lacking the t(11; 14)(q13; q32) as detected by several approaches including next-generation sequencing, fluorescence in situ hybridization using CCND1 break apart probe and fusion probes for t(11; 14)(q13; q32), and conventional karyotyping. These cases therefore simulated prolymphocytic variants of MCL. The incidence of this phenomenon is unknown, and awareness of this potential alternate protein expression pattern is important in order to avoid diagnostic errors.
Lateral Proboscis (Elephant Tusk) with Orofacial Clefts: A Report of a Rare Case
Authors: Ajike Sunday O. , Mohammed Rabiu , Johnson Adegbenga O. , Chaha Kato , Samaila Modupe O.
Published: September 2018

Lateral proboscis is a rare congenital anomaly. Lateral proboscis is a rare craniofacial malformation characterized by a rudimentary tubular, nose-like structure occurring in association with a wide spectrum of other anomalies. We presented a seven-month-old girl’s lateral proboscis, cleft lip, and palate. Proboscis was excised by an elliptical incision, and the cleft was repaired at the same surgery.
The Pathogenicity ofShewanella algaeand Ability to Tolerate a Wide Range of Temperatures and Salinities
Authors: Tseng Shu-Ying , Liu Po-Yu , Lee Yi-Hsuan , Wu Zong-Yen , Huang Chiu-Chen , Cheng Ching-Chang , Tung Kwong-Chung
Published: September 2018

Shewanella algaeis a rod-shaped Gram-negative marine bacterium frequently found in nonhuman sources such as aquatic ecosystems and has been shown to be the pathogenic agent in various clinical cases due to the ingestion of raw seafood. The results of this study showed thatS. algaewas present in approximately one in four samples, including water and shellfish samples. Positive reactions (API systems) inS. algaestrains were seen for gelatinase (gelatin); however, negative reactions were found for indole production (tryptophan).S. algaeis adapted to a wide range of temperatures (4°C, 25°C, 37°C, and 42°C) and salinity. Temperature is a key parameter in the pathogenicity ofS. algaeas it appears to induce hemolysis at 25°C and 37°C.S. algaeexhibits pathogenic characteristics at widely varying temperatures, which suggests that it may have the ability to adapt to climate change.
Parapharyngeal Abscesses Caused by Group G Streptococcus
Authors: Tajima Shori , Anzai Takashi , Matsuoka Rina , Okada Hiroko , Ide Takuma , Fujimaki Mitsuhisa , Kaya Shota , Ito Shin , Ikeda Katsuhisa
Published: September 2018

Deep neck abscess is a life-threatening infection that causes laryngeal edema and upper airway occlusion. The predominant bacterial species involved in this disorder is group A streptococcus. Group G streptococcus (GGS) constitutes the normal commensal flora of the human upper airway. Although rarely, it can cause pharyngitis, tonsillitis, and peritonsillar abscess. Here, we report a case of a woman with parapharyngeal abscess caused by GGS. A 56-year-old woman presented to the emergency department with complaints of sore throat and cervical swelling, and a diagnosis of parapharyngeal abscess was established. She had upper airway occlusion, requiring urgent tracheostomy. Endoscopic incision and drainage of the abscess using a specially designed, rigid curved laryngoscope was successfully performed. Since a rigid curved laryngoscope creates a wide viewing field and working space, it was useful for incision and drainage of the parapharyngeal abscess.
Creatinine- and Cystatin C-Based Incidence of Chronic Kidney Disease and Acute Kidney Disease in AKI Survivors
Authors: Rimes-Stigare Claire , Ravn Bo , Awad Akil , Torlén Klara , Martling Claes-Roland , Bottai Matteo , Mårtensson Johan , Bell Max
Published: September 2018

Background. Renal dysfunction after acute kidney injury (AKI) is common, potentially modifiable, but poorly understood. Acute kidney disease (AKD) describes renal dysfunction 7 to 90 days after AKI and is determined by percentage change in creatinine from baseline. Chronic kidney disease (CKD) is defined as the estimated glomerular filtration rate (eGFR) less than 60 ml/min/1.73 m2 persisting for more than 90 days. We compared CKD incidence using both creatinine- and cystatin C-based GFR with AKD incidence at 90 days in AKI survivors. Methods. A prospective cohort study was conducted in a Swedish intensive care unit (ICU) between 2008 and 2010. We included AKI patients alive at 90 days. We excluded patients <18 and >100 years, death before follow-up, CKD prior to admission, and follow-up before 60 days or beyond 270 days. Creatinine and cystatin C were measured at 90 days and converted to eGFR (mL/min/1.73 m2). Results. We included 274 patients. At 90-day follow-up, the median creatinine eGFR (MDRD) was 81.6 (IQR 58.6–106.8) and median cystatin C eGFR was 51.5 (IQR 35.8–70.7). The incidence of CKD (eGFR < 60) was 25.8% based on creatinine but 63.7% using cystatin C estimates. AKD was present in 47 patients (18.9%). Age, discharge cystatin C, creatinine at discharge, and female gender predicted creatinine-defined CKD at follow-up. Age, discharge cystatin C, CRRT on ICU, and diabetes were associated with cystatin C-based CKD. Conclusions. In AKI survivors followed up at 3 months, CKD criteria were met in a quarter of patients using creatinine and in two-thirds using cystatin C eGFR. Less than one-fifth of patients fulfilled AKD criteria. The application of AKD criteria may underestimate renal dysfunction in AKI survivors.
Plasma Parameters Effects on Dust Acoustic Solitary Waves in Dusty Plasmas of Four Components
Authors: Mahmoud Abeer A. , Abulwafa Essam M. , Al-Araby Abd-alrahman F. , Elhanbaly Atalla M.
Published: September 2018

The presence and propagation of dust-acoustic solitary waves in dusty plasma contains four components such as negative and positive dust species beside ions and electrons are studied. Both the ions and electrons distributions are represented applying nonextensive formula. Employing the reductive perturbation method, an evolution equation is derived to describe the small-amplitude dust-acoustic solitons in the considered plasma system. The used reductive perturbation stretches lead to the nonlinear KdV and modified KdV equations with nonlinear and dispersion coefficients that depend on the parameters of the plasma. This study represents that the presence of compressive or/and rarefactive solitary waves depends mainly on the value of the first-order nonlinear coefficient. The structure of envelope wave is undefined for first-order nonlinear coefficient tends to vanish. The coexistence of the two types of solitary waves appears by increasing the strength of nonlinearity to the second order using the modified KdV equation.