bluuebunny/crossref_metadata_2025 huggingface dataset:
Influence of Multidrug Resistance 1 Gene Variants on Response to Intravenous Methylprednisolone Pulse in Systemic Lupus Erythematosus
Patients: Preliminary Results
Authors: Attia Doaa H.S. , Dorgham Dalia Ahmed Hamza , Al Maghraby Ahmed Amin , Abdelrazik Manal B. , Aly Ezzat Dina
Published: January 2025

Introduction/Objectives:

Genetic variations could explain individual responses to
drugs. This case-control study aimed to investigate the association between the multidrug resistance
1 (MDR1) gene exonic single nucleotide variants (SNVs), rs1128503/C1236T and
rs1045642/C3435T, and the response to intravenous methylprednisolone in Egyptian patients with
active systemic lupus erythematosus (SLE).

Method:

Real-time polymerase chain reaction was used. Patients were divided into responders
and resistant based on the SLE Disease Activity Index (SLEDAI). The degree of improvement
was determined according to a 7-point Likert scale.

Results:

The study included 80 patients: 40 patients with renal flares and 40 patients with extrarenal
flares. In patients with extrarenal flares, 71.4% of responders had the CT+TT model of the
C1236T variant versus 36.8% of resistant patients (p = 0.028); the T allele was detected in 47.6%
of responders versus 23.7% of resistant patients (p = 0.026). Patients with the TT and CT genotypes,
TT+CT model, and T allele of the C1236T variant had significant improvement based on
the Likert scale compared with the CC genotype, CC model and C allele (p = 0.049, 0.038, 0.010
and <0.001, respectively). In the renal subgroup, patients with the CC genotype and C allele of the
C3435T variant had significant improvement based on the Likert scale compared with the CT
genotype and T allele (p = 0.028 and 0.046, respectively). Patients with the CC model had significantly
lower post-treatment proteinuria compared with the TT+CT model (p = 0.024).

Conclusion:

MDR1 C1236T variant allele and C3435T wild allele seem to enhance the response
to glucocorticoids in Egyptian patients with active SLE.
Date Palm Fruit (Phoenix dactylifera L.) Ameliorated Some Premenstrual
Symptoms: Results from an Intervention Trial for 5 Consecutive Menstrual
Cycles
Authors: Al-Sayyed Hiba F. , Takruri Hamed R. , Bakir Nawal A. , Takruri Dima H. , Hamed Nour M. , Rizeq Lana T. , Sweidan Dima H.
Published: January 2025

Introduction/Objectives:

Premenstrual syndrome (PMS) is the group of symptoms that
occur before menses and remit after that. The pathophysiology of PMS is related to hormonal disturbances.
Date palm fruit (Phoenix dactylifera L.) has many functional properties that are beneficial
for women's health. This study aimed to investigate the effect of feeding dates on PMS symptoms.

Method:

The fruit was fed conveniently to 36 volunteers, 16 and 20 in the control and dates
groups, respectively. To monitor PM symptoms, a questionnaire was developed, validated, and
tested for reliability.

Results:

Results of this research yielded a valid (KMO, Barlett factor, and ꭕ2 test values of 0.541,
<0.001, and 0.105 respectively) reliable (Cronbach’s-α value= 0.761) questionnaire. Feeding dates
caused earlier onset of mood changes (0.017*), heavy bleeding (0.012*), and bleeding clots
(0.025*). The onset of mood changes correlated significantly (P=0.048*) and negatively (r2= -
0.347) with luteinizing hormone. Additionally, prolactin was correlated significantly and negatively
with the onset of abdominal cramps. Within the same line, progesterone was correlated negatively
with vaginal secretions (r2= - 0.389, P=0.016*). On the other hand, breast tenderness was
correlated (r2=0.391) significantly (P=0.022*) with 17-β-estradiol.

Conclusion:

This study showed an ameliorating effect of dates on some PMS symptoms, i.e., abdominal
cramps, mood changes, heavy bleeding, vaginal secretions, and bleeding clots.
Effect of Oral Posaconazole on Venetoclax Plasma Concentration and its Efficacy in Patients with Acute Myeloid Leukemia
Authors: Guo Mengqi , He Yingzhi , Du Jingwen , Qiu Dezhi , Qin Yinjie , Huang Yuxian
Published: January 2025

Background:

BCL-2 was the first gene identified to have antiapoptotic effects, and
venetoclax is an oral selective BCL-2 inhibitor, which has great potential in the treatment of patients
with acute myeloid leukemia (AML) who are not candidates for intensive therapy. Notably,
posaconazole, an oral antifungal drug, is also a strong factor that can affect blood venetoclax concentrations.
To the best of our knowledge, the relationship between BCL-2 expression, posaconazole,
and venetoclax, as well as their influence on treatment efficacy and the prognosis of patients
with AML, has not been reported.

Objectives:

In this single-center retrospective study, the relationship between BCL-2 expression
and blood venetoclax concentration was analyzed in 35 patients with AML. After that, we explored
the differences in curative effect, adverse reactions, and outcomes between patients with
different BCL-2 expression levels and patients with different venetoclax concentration levels, respectively.

Methods:

BCL-2 mRNA expression levels were examined by reverse transcription quantitative
PCR. Blood venetoclax concentrations were measured using high-performance liquid chromatography-
tandem mass spectrometry.

Results:

The results revealed that among patients with AML, those with lower primary BCL-2 expression
had a higher complete remission (CR) rate (p =0.005), overall response (OR) rate (p
<0.0001), and progression-free survival time (p =0.04). Posaconazole was revealed to be a strong
factor that was able to increase blood venetoclax concentration (p <0.001) and CR rate in the venetoclax
plus posaconazole group compared to that in the venetoclax monotherapy group (p
=0.002); however, no significant difference was identified in the occurrence of adverse reactions
between these groups. Among low and high-blood venetoclax concentration groups, the event-free
survival of the former group was significantly higher (p =0.013).

Conclusion:

Higher levels of BCL-2 expression at initial diagnosis may have adverse effects on
the efficacy and prognosis of patients, and higher levels of venetoclax concentration may advance
the time of adverse reactions in patients, thus adversely affecting event-free survival (EFS).
A Deep Learning Method for Identifying G-Protein Coupled Receptors based on a Feature Pyramid Network and Attention Mechanism
Authors: Lv Zhe , Hu Siqin , Wei Xin , Qiu Wangren
Published: January 2025

Background:

G-protein coupled receptors (GPCRs) represent a large family of membrane
proteins, distinguished by their seven-transmembrane helical structures. These receptors play a pivotal
role in numerous physiological processes. Nowadays, many researchers have proposed computational
methods to identify GPCRs. In the past, we introduced a powerful method, EMCBOW-GPCR,
which was designed for this purpose. However, the feature extraction technique employed is susceptible
to out-of-vocabulary errors, indicating the potential for enhanced accuracy in GPCR identification.

Methods:

To solve the challenges, we propose a novel approach termed GPCR-AFPN. This method
leverages the FastText algorithm to effectively extract features from protein sequences. Additionally,
it employs a powerful deep neural network as the predictive model to improve prediction accuracy.

Results:

To validate the efficacy of the proposed GPCR-AFPN method, we conducted five-fold
cross-validation and independent tests, respectively. The experimental results indicate that GPCRAFPN
outperforms existing methods.

Conclusion:

Overall, our proposed method, GPCR-AFPN, can improve the accuracy of GPCR identification.
For the convenience of researchers interested in applying our latest advancements, a userfriendly
webserver for GPCR-AFPN is available at www.lzzzlab.top/gpcrafpn/, and the corresponding
code can be downloaded at https://github.com/454170054/GPCR-AFPN.

conclusion:

GPCR-AFPN has a significant advantage for the identification of GPCRs compared to the current state-of-the-art methods of the field.

other:

For the convenience of researchers interested in applying our latest advancements, a user-friendly webserver for GPCR-AFPN is available at http://47.121.208.99/gpcrafpn/ and the corresponding code can be downloaded at https://github.com/454170054/GPCR-AFPN.
Rare of Gaucher's Disease Complication of Splenic Multiple Gaucheroma
Authors: Çukadar Nursima , Vezi̇roğlu İrem Erdoğan , Kara Canan Sehit , Karahan Okkes Ibrahim , Talih Tutkun , Bayram Fahri
Published: January 2025

Background:

Gaucheromas, pseudotumors composed of Gaucher cells, are rare complications
of Gaucher’s Disease (GD). They are usually seen in patients receiving enzyme replacement.
Surgery is generally not recommended for these benign masses in treatment management.
Most patients treated with Enzyme Replacement Therapy (ERT) show organ enlargement and improvement
in laboratory values. In our case, no change in the size of the lesions was observed despite
4 years of standard dose ERT.

Case presentation:

A 27-year-old female, not having a known chronic disease and occasionally
consulting doctors due to bone pain, weakness, and fatigue, visited the emergency department
with the complaint of a nosebleed four years ago. The patient was found to have hepatosplenomegaly
in physical examination and was referred to the hematology clinic because of pancytopenia.
According to the physical examination and laboratory results, the desired leukocyte glucocerebrosidase
level was 0.4 micromol/lt/hour (normal range > 2.5). Homozygous mutations of
p.L483P and L483P were observed in genetic tests. Based on these results, the patient was diagnosed
with GD. Although the patient received regular weekly treatment for 4 years, no significant
change was observed in the spleen size. The patient was admitted to the hospital in April 2022
with complaints of abdominal fullness and indigestion. Her quality of life was deteriorating due to
massive splenomegaly. A splenectomy was performed on the patient. In our case, splenic
gaucheroma, a rare complication of Gaucher’s disease, was found to be present.

Conclusion:

These masses, which are a rare complication of GD, have started to be better recognized
by radiologists and clinicians thanks to the case series shared, and it is clear that there is a
need for standardization and further research in this field. With an increase in the number of cases
and experiences in this field, there will inevitably be different and new developments in follow-up
and treatment approaches.
Nonlinear Quasi-static Investigation of Microbeam Embedded with Micro SMA Wires Considering Size Effects and Phase Transformation
Authors: Dehkordi Mohsen Botshekanan , Fallah Ahmad
Published: January 2025

Introduction:

The size effect on the quasi-static analysis of microbeams embedded with
micro shape memory alloys (SMAs) has not been studied as per today. Therefore, in the present research,
the nonlinear bending performance of the microbeam comprising SMA micro SMA wires is
implemented considering the size effects regarding the coupled geometric and material nonlinearities
for the first time. The SMA has different properties depending on the amount of strain at each
point of the microbeam. Moreover, the amount of strain depends on the SMA properties. This mutual
dependence between SMA properties and strain leads to increased complexity in the analysis.

Method:

In this research, the formulation presented by Lagoudas and Hernandez is used for modeling
the phase transformation and capturing the size effects for the SMA microwires. Via the modified
couple stress theory, the size effect of the matrix material is captured.

Result:

The nonlinear equations of motions are obtained by the principle of virtual work, using the
von Karman strains and, Timoshenko beam theory for different boundary conditions. Then the return
mapping scheme and also iterative nonlinear finite element methods were used for solving the
governing equations. The results are presented according to the distribution of martensitic volume
fraction (MVF), transverse deflection, distribution of strain, stress-strain graph, and variations of the
elasticity modulus of the embedded micro SMA wires. A comparison of some obtained results with
available references indicates the present work’s validity.

Conclusion:

One of the most important findings of this work is that increasing the value of the
length-scale factor as well as increasing the diameter of the micro SMA wires will reduce the maximum
transverse deflection of the microbeam.
General Aspects of Metabolic Syndrome: An Update on Diagnostic Criteria, Pathophysiology, and Management
Authors: Senyigit Abdulhalim
Published: January 2025

Metabolic syndrome (MetS) is generally defined as a cluster/complex of
factors that are risk factors for cardiovascular disease (CVD) and type 2 diabetes
(T2DM), including hyperglycemia, insulin resistance, hypertension,
hypertriglyceridemia, decreased HDL-cholesterol concentration and central obesity.
MetS is a health problem whose prevalence is increasing worldwide and negatively
affects people's lives. Although MetS is essentially insulin resistance (IR), is not
considered a disease, it consists of a combination of many risk factors that force the
body metabolism to work abnormally. In addition to factors such as sedentary lifestyle
and nutrition, hereditary factors are also important in the formation of MetS. The main
components of MetS can be listed as hyperglycemia, hypertension, obesity and
dyslipidemia. MetS has different definitions for different organizations. The basic
components of these definitions are waist circumference, IR, high blood pressure and
dyslipidemia (high triglyceride, low HDL cholesterol). The most recently agreed upon
diagnostic criteria for MetS are increased waist circumference (society and country
specific), high triglycerides, low HDL cholesterol, high blood pressure and high fasting
blood glucose. For diagnosis, the presence of at least 3 of these parameters is required.
When countries are examined in terms of the prevalence of MetS, different results are
obtained from each country. The most important factor affecting the incidence of MetS
in a country is the percentage of obesity and abdominal obesity in that country.
Although obesity and physical activity factors have an impact on the incidence of
MetS, it is an undeniable fact that genetic factors also have a significant impact.
Lifestyle changes are at the core of MetS treatment. People with this syndrome need to
change their diet, increase their physical activity and lose weight. Determining MetS
risk levels and predisposing risk factors, determining whether they meet diagnostic
criteria, and raising awareness through education and consultancy activities will be
effective in combating the prevalence of MetS and cardiovascular risk factors.
Association of Metabolic Syndrome with Gastrointestinal Disorders
Authors: Berrin Papila
Published: January 2025

Metabolic syndrome (MetS) is a collection of risk factors that should be
evaluated for cardiovascular diseases, which are increasing in frequency worldwide. It
is a prothrombotic and proinflammatory condition in which insulin resistance plays a
central role and manifests itself with abdominal obesity, high triglyceride levels,
atherogenic dyslipidemia, high blood pressure and high blood glucose. The intestinalblood barrier, also known as the intestinal barrier, plays an important role in
maintaining the homeostasis of the organism. The intestinal barrier ensures nutrient
uptake through the lumen and at the same time restricts the passage of harmful
substances. Increasing evidence suggests a relationship between intestinal barrier
function and other body systems. Many studies have identified insulin resistance and
metabolic syndrome as risk factors for reflux oesophagitis. Insulin resistance is also
associated with metabolic syndrome and is known as a fundamental factor in its
development. Abdominal obesity in particular is an independent risk factor for erosive
esophagitis and increases the symptoms of gastroesophageal reflux. Subcutaneous and
visceral adipose tissues, the main feature of MetS, secrete a variety of bioactive
substances known as adipocytokines. Activation of inflammatory signaling pathways in
the metabolic syndrome results in altered circulating and tissue levels of
proinflammatory and anti-inflammatory cytokines, leading to systemic inflammation
and tissue damage. The process of microbial dysbiosis, in which the ratio of beneficial
to harmful bacteria is disrupted, is associated with many diseases such as inflammatory
bowel disease, cancer, obesity, diabetes and cardiovascular disease. There is a
relationship between the human gut microbiome and obesity.
Novel Metabolic Panel in Metabolic Syndrome
Authors: Dahlia Badran
Published: January 2025

MetS is a multifaceted disease that embraces multiple disorders such as
obesity, hyperlipidemia, hyperglycemia, insulin resistance, and hypertension. These
disorders are characterized by specific metabolic aberrations presenting at different
stages, which can be detected and monitored through a wide panel of serum
biomarkers. Providing a minimally invasive technique thus can help greatly in the
prediction, early screening and management of metabolic syndrome in high-risk
communities and minimize its complications.
However, no sole biomarker is sensitive nor distinct for the diagnosis of metabolic
syndrome, arousing the necessity of performing a panel that includes related
biomarkers.
Metabolic biomarkers associated with metabolic syndrome are released primarily due
to lipid accumulation and the dysregulated production of adipokines (ex. leptin,
adiponectin) or oxidative stress brought on by obesity (ex. malondialdehyde, F-2
isoprostanes, paraoxonase, and oxidized LDL) or the associated inflammatory reaction
(ex.IL-6, IL-10, tumor necrosis factor (TNFα), uric acid as well as heparanase).
Since obesity and insulin resistance are the cornerstones in metabolic syndrome
pathogenesis, Leptin, an adipokine whose function is to reduce appetite and increase
energy expenditure, and adiponectin represent striking biomarkers for metabolic
syndrome.
In addition, the importance of uric acid, the product of purine metabolism, as a prooxidant inflammatory marker that contributes to metabolic syndrome pathogenesis has
also been elucidated in multiple studies.Recently, a newly discovered metabolic syndrome biomarker, ‘’Heparanase (HPA)” is
closely related to the degradation of heparan sulfate proteoglycan (HSPG) and is
associated with inflammatory responses as it could be secreted by various immune cells
including macrophages.Since many studies have denoted the role of many biomarkers related to metabolic
syndrome, this chapter will highlight the newly discovered ones that will help in the
construction of a metabolic panel that could pave the way to precision medicine and
help personalize the treatment given to metabolic syndrome patients.
Role of Exercise in Metabolic Syndrome
Authors: Seyma Dumur
Published: January 2025

Metabolic syndrome (MetS) is a primary and increasing public health
problem as a result of worldwide urbanization, excessive energy intake, and increasing
sedentary lifestyles. MetS is a combination of the interrelated risk factors of
cardiovascular disease, diabetes and obesity. These factors are dysglycemia,
dyslipidemia, elevated blood pressure, insulin resistance or type 2 diabetes, and low
HDL levels. Clinical and epidemiological studies show that these factors are strongly
associated with cardiovascular risk factors. The worldwide incidence of MetS varies,
depending on the region, urban or rural situation, as well as the gender, age, race, and
ethnicity of the population studied. Effective preventive approaches include weight
loss, dietary habits with high content of industrialized foods, the use of appropriate
pharmacological agents, and exercise to reduce specific risk factors of MetS. Many
physicians treat each of the components of MetS separately. But instead, a solution
should be found to address all these factors together. As discussed in this chapter,
exercise plays a very crucial role in controlling insulin activity, reducing the risk of
cardiovascular disease, and maintaining weight control. Various studies have proven
that effective exercise provides positive results in treating MetS components. The aim
of this chapter is to explain the effects of physical activity on MetS in light of current
information about MetS.
Microbiota and Metabolic Syndrome
Authors: Fatma Köksal Çakırlar
Published: January 2025

Composed of trillions of microorganisms, the human GutM plays a key role
in maintaining general health and metabolic homeostasis. MetS is a complex and
common health condition characterized by a number of metabolic abnormalities,
including obesity, insulin resistance, hypertension, and dyslipidemia. Evidence
emerging in recent years indicates that human GutM plays a crucial role in the
pathophysiology of MetS. In this chapter, we will discuss the composition and
functionality of GutM, as well as the dynamic and complex relationship between
GutM's influence on metS development and progression. By reviewing relevant studies
and literature, we will try to shed light on potential therapeutic strategies and
innovative approaches targeting GutM, mitigating the negative effects of MetS.
Pathophysiological Mechanisms in Obstructive Sleep Apnea Syndrome
Authors: Demet Aygun
Published: January 2025

Metabolic syndrome is a condition characterized by a cluster of risk factors
associated with cardiovascular disease. These metabolic factors include abdominal
obesity, high blood pressure, impaired fasting glucose, high triglyceride levels, and low
HDL cholesterol levels. Obstructive sleep apnea syndrome (OSAS) is a sleep disorder
in which the air passages constrict during sleep, leading to repeated breathing
interruptions. The prevalence of OSAS has increased over the years, particularly
among aging individuals. Although the underlying reasons for airway obstruction
involve various factors, such as overweight, anatomical abnormalities, shifts in airway
dynamics, pharyngeal neuropathy, and fluid redistribution, these causes remain
incompletely understood.
The primary characteristics of OSAS include repetitive interruptions in breathing,
resulting in heightened susceptibility to a range of chronic ailments. These
interruptions lead to intermittent episodes of low oxygen levels (hypoxia) and elevated
carbon dioxide levels (hypercapnia), often accompanied by sleep disruptions due to
arousal.
In this yet-to-be-published exploration, I navigate the intricate dynamics of human
connection in the digital age, examining how technology both bridges and divides us.
Through a blend of personal reflections and sociological analysis, I aim to shed light on
the complexities of virtual relationships and their impact on our sense of belonging.
Metabolic Syndrome and COVID-19
Authors: Neval Elgörmüş
Published: January 2025

Metabolic syndrome (MetS) is a condition of abdominal diseases
characterised by insulin resistance, obesity, atherogenic dyslipidaemia, hypertension,
and hypercoagulability and is a serious risk factor for the development of
cardiovascular diseases (CVD) and type II diabetes mellitus (T2DM) [1]. The outbreak
of SARS-CoV-2 infection has been named Coronavirus Disease 2019 (COVID-19) by
the World Health Organisation (WHO). MetS is emerging as a significant risk factor
for worse outcomes in people with COVID-19. Metabolic diseases, especially chronic
diseases related to diabetes, lead to heart disease and some neurodegenerative diseases
in old age. With SARS-CoV-2, researchers all over the world have investigated the
relationship between metabolic diseases and the virus. In fact, COVID-19 management
is not different from the management of patients with severe and serious diabetes and
the management of other critical illnesses. In the mortality and morbidity of COVID19, the presence of comorbid diseases, especially diabetes (hypertension, obesity,
diseases and drugs affecting the immune system, cardiovascular diseases, etc.) and
advanced age are determinants. It has also been shown that patients with poor
metabolic health are more susceptible to complications such as seizures, strokes, and
encephalitis during COVID-19 due to factors accompanying previous illness. Chronic
diseases are diseases that progress slowly, last three months or longer, are caused by
more than one risk factor, usually show a complicated course, and affect the quality of
life of the person. The end of COVID-19 as a global health emergency does not mean
'the end of COVID-19 as a global health threat'. The threat of different COVID-19
variants emerging that could cause new increases in morbidity and mortality remains.
Monitoring and management of chronic diseases will not only positively change the
course of COVID-19 but will also make it possible to use the limited resources in the
health sector in the right way.
Metabolic Syndrome In Thyroid Disease
Authors: Iskender Ekinci
Published: January 2025

Thyroid diseases significantly influence metabolic parameters, including
blood pressure regulation, glucose metabolism, obesity, hyperlipidemia, and nonalcoholic fatty liver disease (NAFLD). Hypothyroidism is often linked to hypertension,
insulin resistance, and dyslipidemia, while hyperthyroidism may induce weight loss,
insulin resistance, and dyslipidemia. Both hypo- and hyperthyroidism impact blood
pressure regulation, glucose homeostasis, and adiposity. Dyslipidemia is frequently
observed in thyroid disorders, with hypothyroidism associated with elevated
cholesterol levels and hyperthyroidism with altered lipid profiles. Additionally, thyroid
dysfunction contributes to the development of NAFLD. There is a close relationship
between thyroid hormones and metabolic syndrome components, as well as the
development of metabolic syndrome.
Sitting Here, Collecting Dance. Choreography’s affect and value in the Crypto Landscape
Authors: Porter L. Archer
Published: January 2025

This essay explores the emerging phenomenon of dance as a collectible within the crypto landscape, exploring how blockchain technology is reshaping the way dance is valued and experienced. Through the lens of non-fungible tokens (NFTs), the essay examines how dance is being transformed into a collectible object, complicating conventional paradigms of commodification. Focusing on the work of the Chilean dance duo CryptoMoves and the practices of collectors like Anna Condo, the essay highlights how the blockchain not only enables the commodification of dance but also introduces new affective dimensions and knowledge production avenues. By tracing the historical context of dance as both commodity and gift, the essay argues that the NFT marketplace catalyzes a new paradigm where the role of the collector becomes central in defining the cultural and economic value of dance in the 21st century. This shift, as the essay suggests, has profound implications for the future of dance, its cultural identity, and its place within the broader digital economy.
Choreographing Surveillance, Collecting Obfuscated Movement: On View and Human Unreadable by Operator
Authors: Catherine Ania
Published: January 2025

This piece will provide an overview of two artworks, On View (2019) and Human Unreadable (2023), both of which are conceptual artworks that include technology and performance created by Operator, my collaborative art practice with Dejha Ti established in 2016. My background is in choreography and performance art, and Dejha is a multimedia artist and HCI technologist. Rather than go into deep detail about each of the works in all their complexity, I will give a brief overview of the work as a whole and focus the text on the precise moments and instances in which performance and technology interface. Asking such questions as: how does technology and interface design choreograph participation in the audience? How does performance expose the limits of technical systems? How does performativity emerge in new ways through and within the confines of new technologies? How do these mediums evolve when needing to adapt to the limitations of technology? How does technology perform for us? Also, considering the financial hardships associated with performance and the inevitably stunted growth when the ability to take risks disappears, it is certainly worth asking: does blockchain technology and digital scarcity have a role to play in ensuring that performance practices are able to continue evolving? With theaters increasingly being shut down, cultural funding cuts ubiquitous, and the difficulty in the US of sustaining an independent dance company or performance practice, one could say that movement and performance are increasingly being relegated to service industries. The impact of infrastructures for art’s creation, distribution, financialization, and preservation cannot be overstated; while it is interesting to discuss performance and technology from an artistic innovation perspective, there are equally important considerations and conversations to be had about technology’s potential role in supporting the continued evolution of performance as a medium.
Research on the Whole Life Cycle Assessment of Automobile Instrument Cross Beam Based on Lightweight
Authors: Xu Jianquan , Liu Jinwen , Lei Wen , Lu Zhong , Ying Long
Published: January 2025

To study the environmental impact of automobile components, life cycle assessment (LCA) is adopted to study the environmental impact of instrument cross beams made of steel and magnesium alloy crossbeams. Comparative environmental impact analyses of both instrument crossbeams are conducted through parametric analysis, scenario analysis, sensitivity analysis, and future forecasting in GaBi10. The results show that global warming potential (GWP), acidification potential (AP), eutrophication potential (EP), ozone depletion potential (ODP), and photochemical ozone generation potential (POCP) of steel instrument crossbeams are better than those of magnesium alloy crossbeams at a running mileage of 150,000 km, with 534,400 km as a turning point for GWP. The sensitivity analysis shows that a 10% reduction in raw material usage would lead to a 1.65% decrease in GWP for the steel beam and a 6.46% decrease for the magnesium alloy beam. Similarly, a 10% reduction in operating power would result in a 6.83% decrease in GWP for the steel beam and a 3.12% decrease for the magnesium alloy crossbeam. Furthermore, a future scenario analysis was conducted in GaBi, using China's projected electricity emissions data for 2025, 2030, and 2040. The results show that, under these scenarios, the GWP reduction for steel crossbeams is more than double that of magnesium alloy crossbeams, indicating a significantly more significant reduction. This paper provides a theoretical basis for research on the environmental impact of automobile lightweighting.
Measuring Self-Reported Well-Being of Physicians Using the Well-Being Thermometer: Cohort Study
Authors: Adamou Marios , Jones Sarah L , Kyriakidou Niki , Mooney Andrew , Pattani Shriti , Roycroft Matthew
Published: January 2025

Background

Advancements in medical science have focused largely on patient care, often overlooking the well-being of health care professionals (HCPs). This oversight has consequences; not only are HCPs prone to mental and physical health challenges, but the quality of patient care may also endure as a result. Such concerns are also exacerbated by unprecedented crises like the COVID-19 pandemic. Compared to other sectors, HCPs report high incidence of stress, depression, and suicide, among other challenging factors that have a significant negative impact on their well-being.

Objective

Given these substantial concerns, the development of a tool specifically designed to be used in clinical settings to measure the well-being of HCPs is essential.

Methods

A United Kingdom–based cross-sectional pilot study was carried out to measure self-reported well-being in a cohort of 148 physicians, using the newly developed well-being thermometer. The aim of the tool is to allow respondents to develop an individual sense of “well-being intelligence” thus supporting HCPs to have better insight and control over their well-being and allow insights into how to manage it. The tool consists of 5 well-being domains—health, thoughts, emotions, spiritual, and social. Each domain can be measured individually or combined to produce an overall well-being score.

Results

The tool demonstrated good internal consistency; the Cronbach α in this study was 0.84 for the total scale.

Conclusions

Results from this cohort demonstrated that the well-being thermometer can be used to gather intelligence of staff well-being. This is a promising new tool that will assist HCPs to recognize their own well-being needs and allow health care organizations to facilitate change in policies and practices to reflect a better understanding of staff well-being.
Use of Educational Technology in Inclusive Primary Education: Protocol for a Systematic Review
Authors: Ranzato Erica , Holloway Catherine , Bandukda Maryam
Published: January 2025

Background

Educational technology (EdTech) has been instrumental in the last few decades in promoting inclusive education by overcoming various learning barriers and offering tools and opportunities to all students, including those with special educational needs and disabilities (SEND). However, there is limited understanding of current classroom practices and policies and of the effects of the COVID-19 pandemic on EdTech use in the inclusive classroom.

Objective

This systematic review aims to outline the current knowledge on the use of EdTech to support the learning of students with SEND in inclusive primary schools in high-income countries.

Methods

We followed the PRISMA-P (Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols) and the Generalized Systematic Review Registration Form in reporting the details of this protocol. The inclusion criteria for the systematic review require that studies focus on students with SEND who are attending the primary stage of school in high-income countries. The studies can be qualitative or quantitative and should explore the design and use of EdTech with these students. Eligible studies must be published between 2016 and 2024, be peer-reviewed, and be available in English. We systematically searched the ACM, Directory of Open Access Journals, British Educational Index, ERIC, Google Scholar (first 100 records), IEEE, PsycINFO, Scopus, and Web of Science databases. The titles and abstracts of all records will be screened for relevance according to the inclusion criteria. Following this, the full text of the articles will be screened. To ensure the reliability of the screening process, an independent reviewer will screen a percentage of the records for the first screening round. The data extraction process for this systematic review will start with a pilot stage to validate and eventually update the list of entities to be extracted. Following the pilot stage, the final data extraction will be undertaken. An independent reviewer will extract data from a subsample of the records to ensure the reliability of the data extraction process.

Results

The database search was conducted in July 2024. The database search identified a total of 547 records. It is anticipated that the study findings will be submitted for publication in a peer-reviewed journal by the end of January 2025.

Conclusions

This study will provide up-to-date evidence of the use of EdTech in inclusive primary school settings in high-income countries and will describe the impact of the COVID-19 pandemic on the use of EdTech with students with SEND.

International Registered Report Identifier (IRRID)

DERR1-10.2196/65045
Unveiling Sociocultural Barriers to Breast Cancer Awareness Among the South Asian Population: Case Study of Bangladesh and West Bengal, India (Preprint)
Authors: Hamid Fahmida , Roy Tania
Published: January 2025

BACKGROUND

Bangladesh and West Bengal, India, are 2 densely populated South Asian neighboring regions with many socioeconomic and cultural similarities. In dealing with breast cancer (BC)–related issues, statistics show that people from these regions are having similar problems and fates. According to the Global Cancer Statistics 2020 and 2012 reports, for BC (particularly female BC), the age-standardized incidence rate is approximately 22 to 25 per 100,000 people, and the age-standardized mortality rate is approximately 11 to 13 per 100,000 for these areas. In Bangladesh, approximately 90% of patients are at stages III or IV, compared with 60% in India. For the broader South Asian population, this figure is 16%, while it is 11% in the United States and the United Kingdom. These statistics highlight the need for an urgent investigation into the reasons behind these regions’ late diagnoses and treatment.

OBJECTIVE

Early detection is essential for managing BC and reducing its impact on individuals. However, raising awareness in diverse societies is challenging due to differing cultural norms and socioeconomic conditions. We aimed to interview residents to identify barriers to BC awareness in specific regions.

METHODS

We conducted semistructured interviews with 17 participants from West Bengal and Bangladesh through Zoom (Zoom Video Communications). These were later transcribed and translated into English for qualitative data analysis. All our participants were older than 18 years, primarily identified as female, and most were married.

RESULTS

We have identified 20 significant barriers to effective BC care across 5 levels—individual, family, local society, health care system, and country or region. Key obstacles include neglect of early symptoms, reluctance to communicate, societal stigma, financial fears, uncertainty about treatment costs, inadequate mental health support, and lack of comprehensive health insurance. To address these issues, we recommend context-specific solutions such as integrating BC education into middle and high-school curricula, providing updates through media channels like talk shows and podcasts, promoting family health budgeting, enhancing communication at cultural events and religious gatherings, offering installment payment plans from health care providers, encouraging regular self-examination, and organizing statewide awareness campaigns. In addition, social media can be a powerful tool for raising mass awareness while respecting cultural and socioeconomic norms.

CONCLUSIONS

Fighting BC or any fatal disease is challenging and requires support from various dimensions. However, studies show that raising mass awareness is crucial for the early detection of BC. By adopting a sensitive and well-informed approach, we aim to improve the early detection of BC and help reduce its impact on South Asian communities.
Intervensi latihan keterampilan motorik kasar pada fungsi kognitif anak usia prasekolah
Authors: Inayah Inayah , Khasana Tri Mei
Published: January 2025

Gross motor skills training on cognitive function in early primary schoolBackground: Low gross motor skills are associated with low physical activity in preschool and elementary school children. Children's gross motor skills are correlated with obesity and contribute to physical activity participation and physical, social, and cognitive growth.Objective: This study aims to determine the effect of gross motor skills training intervention on the cognitive function of early elementary school children.Methods: A quasi-experimental study with a one-group pretest-posttest with a control design. The study involved first-year children from two elementary schools in Pleret, Bantul, DIY, with a total of 90 participants (49 boys, 41 girls) and a mean age of 7 years. The intervention consisted of motor skills training, including obstacle courses and walking on a balance beam, with each session lasting 15 minutes and conducted once a week for nine weeks. Cognitive function in terms of memory and attention abilities was assessed using the Stroop test (Stroop color and word test) and the digit span test (forward and backward)—data analysis using paired sample t-test and independent sample t-test.Results: The study's results indicated a significant difference in the mean scores of the Stroop test for both the intervention and control groups and the digit span test for the intervention group. The findings suggested that motor skills training intervention significantly positively affected children's cognitive function, particularly with the Stroop test.Conclusions: Gross motor skill training can enhance the cognitive function of children aged 6-7. Motor skill instruction should be incorporated into preschool and early elementary school programs to help narrow the academic achievement gap.
Individual dietary diversity score dan kejadian stunted pada anak prasekolah di Kota Padang
Authors: Purnakarya Idral , Ramayanti Sri , Sari Desy Purnama
Published: January 2025

Individual dietary diversity score and stunted in preschool children in Padang Background: Stunting is a disorder of growth and development in children due to chronic malnutrition and recurrent infections, characterized by substandard length and height.Objective: The study assesses the relationship between individual dietary diversity scores and stunting in preschool children in Padang.Methods: The study used a cross-sectional design. The sample of this study was 267 preschool children aged 3-5 years in Padang who were taken by multi-stage random sampling. Data was collected through child height measurements and individual dietary diversity score (IDDS) for food grouping measured by a 24-hour dietary recall. The data was analyzed using the Chi-Square test.Results: The results showed that 9.7% of preschool children were stunted, and 41.6% of preschool children had lower dietary diversity. The results of the study found was not significantly relationship between individual dietary diversity score and the incidence of stunting in pre-school children in Padang (p-value>0.05).Conclusions: Preschool children with IDDS secure to have a lower risk of stunting. Through a comprehensive approach that prioritizes improving dietary diversity, it is expected to be a key strategy in efforts to reduce stunting in Padang City.
Cuerpos y voces de mujeres en contextos de violencia armada: memoria integeneracional de infancias
Authors: Saldarriaga Vélez Jaime Alberto , Marín Mejía Milena , Tobón Ortiz Valeria , Londoño Rojas Valeria , Marín Posada Mary Luz
Published: January 2025

Este artículo es el resultado de una investigación que buscó comprender y visibilizar el significado de ser o haber sido niña en el contexto de la violencia armada, de mujeres de diferentes generaciones en la Comuna 2 Santa Cruz, Medellín, Colombia. Históricamente, sabemos que las mujeres y las niñas han sido invisibilizadas y silenciadas en medio de la violencia armada, así que el enfoque hermenéutico de la presente investigación posibilitó, metodológicamente, una tertulia de mujeres, o tertuliadero, que generó vínculos de confianza y develó las subjetividades y cosmovisiones de las participantes. Asimismo, se tejieron memorias de experiencias vividas por las niñas de distintas generaciones en el territorio atravesado por actores armados y en intersección con diferentes violencias: de género, patriarcal, adultocéntrica y doméstica. No obstante, las mujeres hicieron memoria conjuntamente y desarrollaron acciones de paz, esperanza y sororidad que reconstruyen comunidad y territorio.
Educación propia del pueblo Nasa: Tensiones y desencuentros frente al modelo etnoeducativo adoptado por el Estado colombiano para antender la diversidad étnico - cultural
Authors: Cardona Orozco Manuel Alejandro
Published: January 2025

Este artículo se deriva de una investigación desarrollada en el marco de la Maestría en Estudios Latinoamericanos de la Universidad Andina Simón Bolívar. En él, se busca establecer en qué consisten las tensiones entre la propuesta de etnoeducación adoptada por el Estado colombiano y la educación propia intercultural desarrollada e implementada por los indígenas del pueblo Nasa. Metodológicamente, se adoptó un enfoque cualitativo crítico en la búsqueda de potenciar los saberes colectivos. Para recuperar la información, se utilizaron tres técnicas: 1) Entrevistas semiestructuradas con personas vinculadas a procesos de educación propia, 2) Notas de campo e informes laborales del investigador durante su participación en comunidades Nasa, y 3) Revisión de la producción bibliográfica realizada por las organizaciones indígenas, así como tesis y artículos académicos. Posteriormente, se realizó un análisis documental a partir de categorías que emergieron de la propia investigación y se desarrolló una interpretación crítica de la misma con participación parcial de las personas entrevistadas. De esta manera, los resultados de la investigación señalan que las tensiones entre la propuesta de educación propia y la etnoeducación se expresan en tres niveles: i) Participación, ii) Administración, y iii) Acuerdos incumplidos.
The Design and Implementation of Automatic Battery Swap Stations for Electric Vehicles: A Technical Study Focused on Battery Lifting and Transfer Mechanisms
Authors: Xu Junrong , Zhao* Bin
Published: January 2025

With the increasing development of technology, people's living standards have soared, and their awareness of environmental
protection has gradually improved. This has led to a significant shift in transportation preferences, with the proportion of
electric vehicles in private car ownership constantly increasing. Electric vehicles, powered by new energy sources, offer
immense market potential due to their eco-friendly nature. However, despite their promising outlook, the path to their
widespread adoption in China has not been smooth. Numerous challenges and shortcomings, such as limited battery life and
charging infrastructure, still need to be addressed and optimized. Among the myriad of issues hindering the development of
electric vehicles, battery charging stands out as a critical concern. When an electric vehicle's battery runs out, the owner is often
left with the inconvenience of spending considerable time charging it. To alleviate this issue, the establishment of automatic
battery swapping stations for electric vehicles equipped with replaceable batteries has emerged as a viable solution. These
stations would enable electric vehicles to swiftly and conveniently replace their batteries, akin to how fuel vehicles refuel at
gas stations, thereby minimizing downtime and enhancing user convenience. In this paper, we delve into the functionality of
electric vehicle battery replacement and propose a feasible level changer structure scheme. Based on this structural scheme,
we meticulously analyze and calculate relevant data to ensure the feasibility and efficiency of the design. Subsequently, we
design the battery lifting mechanism and the battery pack transmission mechanism of the electric vehicle level changer.