bluuebunny/crossref_metadata_2025 huggingface dataset:
Application of deep learning model in the sonographic diagnosis of uterine adenomyosis
Authors: Raimondo Diego , Raffone Antonio , Aru Anna Chiara , Giorgi Matteo , Giaquinto Ilaria , Spagnolo Emanuela , Travaglino Antonio , Galatolo Federico A. , Cimino Mario G. C. A. , Centini Gabriele , Lazzeri Lucia , Mollo Antonio , Seracchioli Renato , Casadio Paolo
Published: October 2022

Purpose: To evaluate the diagnostic performance of Deep Learning (DL) machine for the detection of adenomyosis on uterine ultrasonographic images and compare it to intermediate ultrasound skilled trainees.
Methods: Prospective observational study conducted between 1st and 30th April 2022. Transvaginal ultrasound (TVUS) diagnosis of adenomyosis was investigated by an experienced sonographer on 100 fertile-age patients. Videoclips of the uterine corpus were recorded and sequential ultrasound images were extracted. Intermediate ultrasound skilled trainees and DL machine were asked to make a diagnosis reviewing uterine images. We evaluated and compared the accuracy, sensitivity, positive predictive value, F1- score, specificity and negative predictive value of the DL model and the trainees for adenomyosis diagnosis.
Results: Accuracy of DL and intermediate ultrasound skilled trainees for the diagnosis of adenomyosis were 0.51 (95% CI, 0.48-0.54) and 0.70 (95% CI, 0.60-0.79), respectively. Sensitivity, specificity and F1-score of DL were 0.43 (95% CI, 0.38-0.48), 0.82 (95% CI, 0.79-0.85) and 0.46 (0.42-0.50), whereas intermediate ultrasound skilled trainees had sensitivity of 0.72 (95% CI, 0.52-0.86), specificity of 0.69 (95% CI, 0.58-0.79) and F1-score of 0.55 (95% CI, 0.43-0.66).
Conclusion: In this preliminary study DL model showed a lower accuracy but a higher specificity in diagnosing adenomyosis on ultrasonographic images compared to intermediate skilled trainees.
Novel Approaches for the Treatment of Inflammatory Diseases: Inhibitors of NF-KB and AP-1
Authors: Suto Mark J. , Ransone Lynn J.
Published: October 2022

The transcription factors (TF's) AP-I and NF-KB play a critical role in the regulation of several proinflammatory cytokines and related proteins and have thus been implicated in a number of immunoinflammatory and proliferative diseases. Recently, a great deal of work has been done to elucidate the regulatory pathways involved in the activation of NF-KB and AP-I. In addition, several antiarthritic drugs have been shown to block the activation of these transcription factors. These observations have led to drug
discovery efforts aimed toward selectively modulating these targets. A variety of compounds have been shown to block these TF' s, however none has shown enough selectivity to warrant further clinical development. Recently, two new series of compounds were identified that block the activation of both NF-KB and AP-1 selectively in T-cells. Subsequently, they were shown to be active in several animal models of inflammation and immunosuppression. Current work is focused on identifying orally-active analogs to be used in the treatment of chronic diseases associated with an overproduction of NF-KB and AP- I.
A Comprehensive Review on Nanomedicine: Promising Approach for
Treatment of Brain Tumor through Intranasal Administration
Authors: Bahadur Shiv , Prakash Anubhav
Published: October 2022

Brain tumors have become one of the deadliest cancers; however, their treatment is still limited by conventional approaches. Brain tumors, among other CNS diseases, are the most lethal form of cancer due to ineffective diagnosis and profiling. The major limiting factor in treating brain tumors is the blood-brain barrier (BBB), and the required therapeutic concentration is not achieved. Hence, most drugs are prescribed at higher doses, which have several unwanted side effects. Nanotechnology has emerged as an interesting and promising new approach for treating neurological disorders, including brain tumors, with the potential to overcome concerns related to traditional therapeutic approaches. Moreover, biomimetic nanomaterials have been introduced to successfully cross the blood-brain barrier and be consumed by deep skin cancer for imaging brain tumors using multimodal functional nanostructures for more specific and reliable medical assessment. These nanomedicines can address several challenges by enhancing the bioavailability of therapeutics through controlled pharmacokinetics and pharmacodynamics. Further nasal drug delivery has been considered as an alternative approach for the brain's targeting for the treatment of several CNS diseases. A drug can be directly delivered to the brain by bypassing the BBB through intranasal administration. This review discusses intranasal nanomedicine-based therapies for brain tumor targeting, which can be explored from different perspectives.
Interleukin-1 in Coronary Artery Disease
Authors: Oikonomou Evangelos , Tsaplaris Paraskevas , Anastasiou Artemis , Xenou Maria , Lampsas Stamatios , Siasos Gerasimos , Pantelidis Panteleimon , Theofilis Panagiotis , Tsatsaragkou Aikaterini , Katsarou Ourania , Sagris Marios , Vavuranakis Michael-Andrew , Vavuranakis Manolis , Tousoulis Dimitris
Published: October 2022

Cardiovascular disease is the leading cause of mortality worldwide. Inflammation has long been established as a key component in the pathophysiology of coronary artery disease. The interleukin-1 family consists of 11 members that regulate the inflammatory response through both pro- and anti-inflammatory properties with the Nod-like receptor (NLR) family pyrin domain con-taining 3 inflammasome having a pivotal role in the process of converting interleukin-1 beta and in-terleukin-18, two key inflammatory mediators, into their mature forms. Interleukin-1 affects various cell types that participate in the pathogenesis of atherosclerosis as it enhances the expression of leu-kocyte adhesion molecules on the surface of endothelial cells and augments the permeability of the endothelial cell barrier, attracting monocytes and macrophages into the vessel wall and aids the mi-gration of smooth muscle cells toward atheroma. It also enhances the aggregation of low-density lipoprotein particles in endothelium and smooth muscle cells and exhibits procoagulant activity by inducing synthesis, cell-surface expression and release of tissue factor in endothelial cells, promot-ing platelet adhesion. The value of interleukin-1 as a diagnostic biomarker is currently limited, but interleukin-1 beta, interleukin-18 and interleukin-37 have shown promising data regarding their prognostic value in coronary artery disease. Importantly, target anti-inflammatory treatments have shown promising results regarding atherosclerosis progression and cardiovascular events. In this re-view article, we focus on the immense role of interleukin-1 in atherosclerosis progression, inflam-mation cascade and in the clinical application of target anti-inflammatory treatments.
It is all About the Chase: Neurosteroidogenesis in Male Rats is Driven by
Control of Mating Pace
Authors: Kohtz Amy S. , Frye Cheryl A.
Published: October 2022

Background:

Masculine sexual behaviors are dependent on androstane-derived steroids;
however, the modulatory effects of mating, and of mating control, on androstane neurosteroidogenesis
remain largely unknown.

Objective:

Herein, we investigated the effects of mating control, prior sexual experience, and age on
brain region specific neurosteroidogenic responses in male rats.

Methods:

Effects of acute sexual experience were tested in naïve male rats that either remained sexually-
naïve, were exposed to a standard mating chamber, or were either given control of the mating
pace in a standard mating chamber (male control) or mated wherein the female stimulus rat controlled
the mating pace in a paced-mating chamber (female control). Aged (10-12 months) sexually responsive
male rats were similarly euthanized from the homecage or engaged in male controlled or female
controlled mating. All rats were euthanized immediately following exposure conditions for radioimmunoassay
of steroids in midbrain, hypothalamus, hippocampus and cortex.

Results:

Consummatory sexual behavior in male vs. female-controlled mating paradigms was altered
by age and prior sexual experience. Male-controlled mating increased androstane neurosteroid metabolism,
such that complementary increases in the testosterone (T) metabolite 5α-androstane-3α-17β-
diol (3α-diol) in the midbrain and hypothalamus of male rats corresponded to decreases in the prohormone,
T. 3α-diol were increased in the hippocampus in response to the context alone, and to a lesser
degree in response to mating. Mating diminished neurosteroidogenesis in the cortex. Neurosteroidogenesis
was overall reduced in aged male rats compared to naïve controls, however, these effects were
more prominent in sexually non-responsive aged male rats.

Conclusions:

Extending previous findings, these results indicate differential production of androstane
neurosteroids in a mating exposure, age and brain region dependent manner.
Electroencephalography Findings in Traumatic Brain Injury
Authors: Kadri Alfansuri , Apriani Novi
Published: October 2022

Traumatic Brain Injury (TBI) or also known as a head injury is one of the leading causes of death among young people and is also one of the health problems defined as impact, penetration, and rapid movement of the brain within the skull that can result in changes in mental status and is often referred to as the silent epidemic.

Head injuries can also result in electrophysiological abnormalities seen on electroencephalography (EEG) recordings. Electroencephalography was the first clinical neurodiagnostic assessment to reveal abnormal brain function after a head injury. For detecting brain injury, EEG may be more sensitive than clinical neurologic examination.

In general conditions, electroencephalography is performed on patients with moderate to severe head injuries to provide information about the severity of the head injury, and establish a diagnosis of non-convulsive status epilepticus. This diagnosis often follows head injuries because patients with loss of consciousness are difficult to identify without an EEG examination. This also helps determine a prognosis for recovery and the likelihood of post-traumatic seizures.

Electroencephalography features in head injuries depend on the severity of the injury and the location of the head itself. Electroencephalography after head injury shows slowing of the posterior dominant rhythm and increasing diffuse theta slowing, which returns to normal within hours or may subside more slowly over several weeks. Electroencephalography changes are not the same in each individual, due to differences in the severity of head injuries. It is important to know that there is no clear or specific EEG for mild traumatic brain injury.
role of cross-cultural adaptability to mediate the effect of cultural intelligence on knowledge sharing of workers of expatriates in Bali
Authors: Jayanto Jayanto , Putra Made Surya
Published: October 2022

This study aims to determine the role of cross cultural adaptability in mediating the influence of cultural intelligence on knowledge sharing of expatriate workers in Bali. This research was conducted on a sample of 167 respondents who are expatriate workers who work in the province of Bali. Determination of the sample is done by using non-probability sampling with incidental sampling technique. Data analysis was performed using Structural Equation Modeling (SEM) using the Partial Least Square (PLS) approach. The results showed that cultural intelligence and cross cultural adaptability had a positive and significant effect on knowledge sharing and cross cultural adaptability was able to partially mediate the influence of cultural intelligence on knowledge sharing. These results illustrate that the knowledge sharing displayed by expatriate workers will be better, if the cultural intelligence they have is high. High cultural intelligence will support good adaptability to new environments, and good adaptability will help expatriate workers to communicate and share knowledge with local workers better. Expatriate workers who have high cultural intelligence will have better cross-cultural adaptability, which will have an impact on the ability to share knowledge that is getting better.
A STUDY ON BUSINESS GROWTH FACTOR TO CREATE INNOVATION PROCESS OF COMPANIES (CASE STUDY IN REFRIGERATED TRUCK COMPANY)
Authors:   Graduate School of Science and Technology for Innovation, Yamaguchi University, Japan, Fujiyama Kojiro , Oktavianty Oke ,   Department of Industrial Engineering, Engineering Faculty, Universitas Brawijaya, Yano Shoichi ,   Yano Special Purpose Vehicle Co., Ltd., Japan, Haruyama Shigeyuki ,   Graduate School of Innovation and Technology Management, Yamaguchi University, Japan
Published: October 2022

Previous studies into the elements that influence the growth factors of SME show that creating new values by innovation is a key to sustainable business progress, and also that there are constant demands for creating innovation in the society. In response to such demands, there have been various models developed on creating innovation. Many have pointed out the importance of grasping the innovation not as a solution for a single problem but for the whole process of engineering development - as a system which integrates the product manufacturing, engineering and business application. Furthermore, such innovation is increasingly considered significant in the studies on the elements influencing the factors that lead to constant progress of business of, not only SME, but also companies in general. In this study, we took an example of a Japanese manufacturer which achieved the position of a niche top and has been successful in continually growing in business to investigate on and analyze the following two subjects; “the elements influencing the growth factor of an enterprise” and “the transition of the growth factors in accordance with each product lifecycle”. The result hereby shows the different elements that can create a value affecting the business growth factors in the respective stages of product lifecycle, such as Introduction, Growth and Maturity.
Public Library Support of College Literacy in Appalachia
Authors: Hands Africa , Candela Rose
Published: October 2022

This poster presents initial findings from phase 1 of an IMLS-funded project. The research question guiding this project is: What affordances relevant to college literacy are available at public libraries for adult prospective students in Central Appalachia? This content analysis examined public library websites across 4 states (KY, TN, VA, WV) comprising the central region of Appalachia. This region has lower educational attainment and income rates and higher unemployment compared to other regions of Appalachia. Prospective students in Appalachia face barriers to advancing their education: academic under-preparedness, lack of information about college and financial aid, and few family members who attended college and can serve as advisors. Challenges have been identified related to adult students’ information experiences including, time constraints, discomfort asking for help, and unfamiliarity with technology to access information and resources. This is an information area in which public libraries must actively engage.
“Are they still anxious?”
Authors: Nieves-Whitmore Kaeli , Sweeney Miriam E.
Published: October 2022

Mellon’s 1986 theory of library anxiety named a phenomenon many librarians were familiar with, and influenced inquiry related to multiple areas of Library and Information Science (LIS). However, Mellon’s study, and the work it inspired, were done in an academic library environment that is drastically different from the academic library of today. Considering the rapid evolution of physical academic libraries alongside shifting societal attitudes towards mental health since the completion of Mellon’s study, it is essential to reevaluate the concept of library anxiety. My dissertation research critically reevaluates the concept of library anxiety in the library of today and asks, “are they still anxious?” or, “anxious in the same way?”. To explore these questions, I have designed a two-part qualitative study. Part one is an analysis of the scholarly literature exploring how the concept of library anxiety has been understood and applied in the field of LIS. Part two of the study explores how that older understanding of library anxiety aligns with students’ experiences of academic libraries today. Using a combination of surveys, interviews, and interactive mapping activities with student library users on a university campus in the Southeast, I identify possible connections between physical academic libraries and students’ emotional experiences as they relate to library anxiety in today’s landscape. This study has the potential to inform library design in ways that support students’ information needs and shed light on some of the affective experiences of student users that are sometimes overlooked as key parts of user experience.
Uprooting Racial Health Disparities
Authors: Gerido Lynette Hammond
Published: October 2022

Genealogical researchers are the largest user group of archives and library special collections. Although the pursuit of family history is a popular hobby in North America, the Centers for Disease Control and Prevention (CDC) reports that many patients do not collect family health history (FHH). Adequate FHH supports diagnosis and risk assessment for hereditary cancers. Referrals to genetic testing services and counseling reflect glaring racial disparities that are partially attributed to inadequate FHH. Library and information science (LIS) education may offer opportunities to introduce archives curriculum in undergraduate programs and foster synergies with community health outreach program design. Supporting the development of accurate FHH and meeting the genealogy needs of diverse communities is a critical example of the influence LIS education may wield in the reduction of racial disparities in hereditary cancer care.
Critical Voices
Authors: Rapchak Marcia , Wiley Paula , Harper Reagan , Linn Brittni , Reis Heidi
Published: October 2022

This article describes how a group of students and an instructor at an MLIS program developed a community of practice (CoP) around critical librarianship. We provide a literature review on CoPs and relate this to our own experience with the reading group. We include our individual narratives that reveal the similarities and differences in our experiences as students and practitioners. The Critical Librarianship Reading Group provided a community for peers, knowledge building around critical librarianship, and an opportunity to hear from a number of voices through the readings and the members of the group. We hope this inspires other MLIS programs to develop their own CoPs that connect students, instructors, and alumni/practitioners
E-Resources and the Privacy Paradigm Shift for Librarians
Authors: Clark Hunt Laura , Steele Jennifer , Lambert Tamatha , Koposko Janet
Published: October 2022

The goal of the current study is to examine e-resource librarians’ perceptions on privacy standards in the U.S. in contrast with the privacy standards of the European Union. The current privacy standards in the U.S. are lax and inconsistent in nature in comparison with the privacy standards of the European Union. As e-resource librarians provide access to library resources, certain patron data is being shared with third party businesses. In many cases, no effort is made to inform users about what information is being shared or who is collecting that information. The information from this study will be used to inform the researcher on privacy values and beliefs of e-resource librarians.
Integration of Artificial Intelligence Into Sociotechnical Work Systems—Effects of Artificial Intelligence Solutions in Medical Imaging on Clinical Efficiency: Protocol for a Systematic Literature Review
Authors: Wenderott Katharina , Gambashidze Nikoloz , Weigl Matthias
Published: October 2022

Background

When introducing artificial intelligence (AI) into clinical care, one of the main objectives is to improve workflow efficiency because AI-based solutions are expected to take over or support routine tasks.

Objective

This study sought to synthesize the current knowledge base on how the use of AI technologies for medical imaging affects efficiency and what facilitators or barriers moderating the impact of AI implementation have been reported.

Methods

In this systematic literature review, comprehensive literature searches will be performed in relevant electronic databases, including PubMed/MEDLINE, Embase, PsycINFO, Web of Science, IEEE Xplore, and CENTRAL. Studies in English and German published from 2000 onwards will be included. The following inclusion criteria will be applied: empirical studies targeting the workflow integration or adoption of AI-based software in medical imaging used for diagnostic purposes in a health care setting. The efficiency outcomes of interest include workflow adaptation, time to complete tasks, and workload. Two reviewers will independently screen all retrieved records, full-text articles, and extract data. The study’s methodological quality will be appraised using suitable tools. The findings will be described qualitatively, and a meta-analysis will be performed, if possible. Furthermore, a narrative synthesis approach that focuses on work system factors affecting the integration of AI technologies reported in eligible studies will be adopted.

Results

This review is anticipated to begin in September 2022 and will be completed in April 2023.

Conclusions

This systematic review and synthesis aims to summarize the existing knowledge on efficiency improvements in medical imaging through the integration of AI into clinical workflows. Moreover, it will extract the facilitators and barriers of the AI implementation process in clinical care settings. Therefore, our findings have implications for future clinical implementation processes of AI-based solutions, with a particular focus on diagnostic procedures. This review is additionally expected to identify research gaps regarding the focus on seamless workflow integration of novel technologies in clinical settings.

Trial Registration

PROSPERO CRD42022303439; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=303439

International Registered Report Identifier (IRRID)

PRR1-10.2196/40485
Exploring the Behavior of Users With Attention-Deficit/Hyperactivity Disorder on Twitter: Comparative Analysis of Tweet Content and User Interactions (Preprint)
Authors: Chen Liuliu , Jeong Jiwon , Simpkins Bridgette , Ferrara Emilio
Published: October 2022

BACKGROUND

With the widespread use of social media, people share their real-time thoughts and feelings via interactions on these platforms, including those revolving around mental health problems. This can provide a new opportunity for researchers to collect health-related data to study and analyze mental disorders. However, as one of the most common mental disorders, there are few studies regarding the manifestations of attention-deficit/hyperactivity disorder (ADHD) on social media.

OBJECTIVE

This study aims to examine and identify the different behavioral patterns and interactions of users with ADHD on Twitter through the text content and metadata of their posted tweets.

METHODS

First, we built 2 data sets: an ADHD user data set containing 3135 users who explicitly reported having ADHD on Twitter and a control data set made up of 3223 randomly selected Twitter users without ADHD. All historical tweets of users in both data sets were collected. We applied mixed methods in this study. We performed Top2Vec topic modeling to extract topics frequently mentioned by users with ADHD and those without ADHD and used thematic analysis to further compare the differences in contents that were discussed by the 2 groups under these topics. We used a distillBERT sentiment analysis model to calculate the sentiment scores for the emotion categories and compared the sentiment intensity and frequency. Finally, we extracted users’ posting time, tweet categories, and the number of followers and followings from the metadata of tweets and compared the statistical distribution of these features between ADHD and non-ADHD groups.

RESULTS

In contrast to the control group of the non-ADHD data set, users with ADHD tweeted about the inability to concentrate and manage time, sleep disturbance, and drug abuse. Users with ADHD felt confusion and annoyance more frequently, while they felt less excitement, caring, and curiosity (all P<.001). Users with ADHD were more sensitive to emotions and felt more intense feelings of nervousness, sadness, confusion, anger, and amusement (all P<.001). As for the posting characteristics, compared with controls, users with ADHD were more active in posting tweets (P=.04), especially at night between midnight and 6 AM (P<.001); posting more tweets with original content (P<.001); and following fewer people on Twitter (P<.001).

CONCLUSIONS

This study revealed how users with ADHD behave and interact differently on Twitter compared with those without ADHD. On the basis of these differences, researchers, psychiatrists, and clinicians can use Twitter as a potentially powerful platform to monitor and study people with ADHD, provide additional health care support to them, improve the diagnostic criteria of ADHD, and design complementary tools for automatic ADHD detection.
Data Challenges for Externally Controlled Trials: Viewpoint (Preprint)
Authors: Velummailum Russanthy Ruthiran , McKibbon Chelsea , Brenner Darren R , Stringer Elizabeth Ann , Ekstrom Leeland , Dron Louis
Published: October 2022

UNSTRUCTURED

The preferred evidence of a large randomized controlled trial is difficult to adopt in scenarios, such as rare conditions or clinical subgroups with high unmet needs, and evidence from external sources, including real-world data, is being increasingly considered by decision makers. Real-world data originate from many sources, and identifying suitable real-world data that can be used to contextualize a single-arm trial, as an external control arm, has several challenges. In this viewpoint article, we provide an overview of the technical challenges raised by regulatory and health reimbursement agencies when evaluating comparative efficacy, such as identification, outcome, and time selection challenges. By breaking down these challenges, we provide practical solutions for researchers to consider through the approaches of detailed planning, collection, and record linkage to analyze external data for comparative efficacy.
Using a Geosocial Networking App to Investigate New HIV Infections and Related Risk Factors Among Student and Nonstudent Men Who Have Sex With Men in Chengdu, China: Open Cohort Study (Preprint)
Authors: Dai Zhen , Mi Guodong , Yu Fei , Chen Guodong , Wang Xiaodong , He Qinying
Published: October 2022

BACKGROUND

In China, condomless sex among men who have sex with men (MSM) is the primary route of HIV infection in young people. Chengdu is a hotspot for reported HIV cases among young people nationwide. Extensive use of geosocial networking (GSN) smartphone apps has dramatically changed the pattern of sexual behavior among young MSM (YMSM). However, data on HIV incidence and the risk behavior of YMSM using the GSN app are still obscure.

OBJECTIVE

This study aims to analyze and understand the HIV incidence and its risk factors among YMSM using GSN apps in Chengdu, China.

METHODS

An open cohort study was conducted among YMSM aged 18-24 years through a gay GSN smartphone app in Chengdu, China, from July 2018 to December 2020. Every participant completed a web-based questionnaire on sociodemographic characteristics, sexual behaviors, and other related statuses; made a reservation for a web-based HIV testing; and then voluntarily got tested at the designated testing site. At least one additional HIV test was taken via the app during the study period, and participants were evaluated at the end of the study or at the time of HIV seroconversion. By dividing the sum of the observed HIV seroconversions by the observed person-years, HIV incidence was calculated and compared between the student and nonstudent MSM. Univariate and multivariate (Cox proportional hazards regression) analyses were used to discuss the risk factors for new HIV infections.

RESULTS

In the study cohort, 24 seroconversions occurred among 625 YMSM who took at least two HIV tests through the app during the study period, contributing to 505 observed person-years. The HIV incidence rate per 100 person-years was 4.75 (95% CI 2.89-6.61) among all MSM, 3.60 (95% CI 1.27-5.93) among student MSM, and 5.88 (95% CI 2.97-8.79) among nonstudent MSM. In addition, the HIV incidence per 100 person-years was 11.11 (95% CI 4.49-17.73) among those who had resided in the area for 6 months or less and 7.14 (95% CI 1.52-12.77) among those with senior high school or less education. Two or more sexual partners (adjusted hazards ratio [HR] 3.63, 95% CI 1.08-12.23) in the preceding 6 months was a risk factor for new HIV infections. Consistent condom use for anal sex (adjusted HR 0.38, 95% CI 0.16-0.88) and insertive anal sex only (adjusted HR 0.10, 95% CI 0.01-0.75) in the preceding 6 months were protective factors for new HIV infections.

CONCLUSIONS

The rate of new HIV infections among YMSM who actively used GSN smartphone apps was high, especially among migrant nonstudent MSM. Targeted interventions on GSN smartphone apps should be implemented to provide demand-adapted prevention and services to reduce the threat of HIV.
How medical journals use Twitter: metadata, network, and content analyses (Preprint)
Authors: Kim Donghun , Jung Woojin , Jiang Ting , Zhu Yongjun
Published: October 2022

BACKGROUND

An increasing number of medical journals are using social media to promote themselves and to communicate with their readers. However, little is known about how medical journals use Twitter and what their social media management strategies are.

OBJECTIVE

To understand how medical journals use of Twitter from a global standpoint, we conducted a broad, in-depth analysis of all the available Twitter accounts of medical journals indexed by major indexing services, with a particular focus on their social networks and content.

METHODS

The Twitter profiles and metadata of medical journals were analyzed, along with the social networks on their Twitter accounts.

RESULTS

The results showed that overall, publishers used different strategies regarding Twitter adoption, Twitter usage patterns, and their subsequent decisions. The following specific findings were noted. 1) Journals with Twitter accounts had a significantly higher number of publications and a greater impact than their counterparts. 2) Subscription journals had a slightly higher (2%) Twitter adoption rate than open access journals. 3) Journals with higher impact had more followers. 4) Prestigious journals rarely followed other lesser-known journals on social media. Additionally, an in-depth analysis of 2,000 randomly selected tweets from four prestigious journals revealed that The Lancet had dedicated considerable effort to communicating with people about health information and fulfilling its social responsibility by organizing committees and activities to engage with a broad range of health-related issues; The New England Journal of Medicine and the Journal of the American Medical Association focused on promoting research articles and attempting to maximize the visibility of their research articles; while the British Medical Journal provided copious amounts of health information and discussed various health-related social problems to increase social awareness of the field of medicine.

CONCLUSIONS

Our study used various perspectives to investigate how medical journals use Twitter and explored the Twitter management strategies of four of the most prestigious journals. Our study provides a detailed understanding of medical journals’ use of Twitter from various perspectives and can help publishers, journals, and researchers better utilize Twitter for their respective purposes.
МЕТАЛЛОКЕРАМИЧЕСКИЕ КОРПУСА АО «ЗПП» ДЛЯ ПОЛУПРОВОДНИКОВЫХ ПРИБОРОВ И МИКРОСХЕМ СИЛОВОЙ ЭЛЕКТРОНИКИ
Authors: Шугаепов Ш. , Ермолаев Е. , Егошин В. , Ахметгалиев Р.
Published: October 2022

Рассмотрены металлокерамические корпуса производства АО «Завод полупроводниковых приборов» (АО «ЗПП») для полупроводниковых приборов и интегральных микросхем силовой электроники. Приведена информация об особенностях и характеристиках этих корпусов.
Проблема информационной безопасности волоконно-­оптических технологий
Authors: Гришачев В.В. , Заболотская А.Д.
Published: October 2022

В работе представлен анализ угроз безопасности информации критической информационной инфраструктуры, функционирующей на основе волоконно-оптических технологий. В предложенной модели выделены три направления угроз конфиденциальности – перехват трафика в оптических сетях; волоконно-оптический канал утечки информации, циркулирующей на защищаемом объекте; несанкционированный доступ к информации с помощью волоконно-оптических средств технической.
СИСТЕМА ПЕРЕДАЧИ КЛЮЧА ШИФРОВАНИЯ НА ОСНОВЕ ПРОТОКОЛА КВАНТОВОЙ КРИПТОГРАФИИ
Authors: Горбадей О. , Зеневич А. , Соловьев А.
Published: October 2022

Представлена реализованная система передачи секретного ключа, основанная на работе протокола квантовой криптографии BB84. Определены параметры и характеристики данной системы. Формируемые ключи проверены на случайность по стандартам NIST.
ЗАДАЧИ ВНЕДРЕНИЯ А-СЕТИ В УПРАВЛЕНИИ ВОЗДУШНЫМ ДВИЖЕНИЕМ
Authors: Шаврин С. , Лихачев Н. , Воронкова М. , Лихачев М.
Published: October 2022

Рассмотрены вопросы обеспечения ситуационной осведомленности пилотов воздушных судов средствами самоорганизующихся сетевых технологий (А–сети) автоматического зависимого наблюдения вещательного типа. Отмечается необходимость и рассматриваются средства обеспечения информационной безопасности передаваемых сообщений в плане поддержки как их конфиденциальности, так и аутентификации, целостности и защиты от повторов ранее переданных.
Data Reduction Analysis on UTM-LST External Balance
Authors: Hasan Mohammed Munif , Mat Shabudin
Published: October 2022

Abstract: The effective use of wind-tunnel testing in determining aerodynamic properties of a body is very much dependent upon the reliability and speed with which wind-tunnel data can be reduced. The operating efficiency of the wind tunnels is substantially improved by the capability of providing lower aerodynamic coefficients in real time, or online, which decreases the expensive wind-tunnel time necessary for each test. This paper describes a system for presenting reduced wind-tunnel data in real time for UTM-LST. The requirements for data-handling equipment and data reduction procedures for wind tunnels are quite diverse, and depend upon the wind tunnel design and the type of tests for which they are used. The supersonic wind tunnels mentioned in this description have a variety of force-balance systems and are used for force tests, pressure tests, and other research projects. Consequently, the problems associated with in order to solve this diversity we build a computerized program where we can find the transformation of axis and aerodynamic characteristics at ease. This program can find the values of different aerodynamic coefficients with certain angle of attacks.
Antitussive, Expectorant, and Anti-inflammatory Effects of Mahwangyounpae-tang, a Polyherbal Formula in ICR Mice
Authors: Jeong Yeong-eun , Kim Jong-dae
Published: October 2022

Objectives: The antitussive, expectorant, and anti-inflammatory effects of Mahwangyounpae-tang (MHYPT) aqueous extracts were observed in appropriate animal models of various respiratory disorders.Methods: MHYPT aqueous extracts were orally administered once a day for 11 days at dose levels of 400, 200, and 100 mg/kg. The effect of MHYPT was determined by comparing its antitussive effect with theobromine (TB), its expectorant effect with ambroxol (AM), and its anti-inflammatory effect with dexamethasone (DEXA).Results: MHYPT aqueous extracts (400 mg/kg) showed favorable antitussive effects comparable to those of TB (50 mg/kg) in the NH4OH-exposure coughing mouse model and expectorant effects comparable to those of AM (250 mg/kg) in the phenol red-secretion mouse model, but MHYPT (400 mg/kg) showed less anti-inflammatory activity compared to DEXA (1 mg/kg) in the xylene-induced acute inflammatory mouse ear model under the experimental conditions used.Conclusion: MHYPT aqueous extracts administered at dosage levels of 400, 200, and 100 mg/kg induced dose-dependent and favorable antitussive, expectorant, and anti-inflammatory activities that occurred by simultaneous modulation of the activity of mast cells and respiratory mucous production under the experimental conditions used in this study.
A Review of Recent Clinical Studies of Acupuncture Treatment for Hiccups - PubMed and Domestic Studies
Authors: Kim Minjeong , Park Chaehyun , Jun Hyejin , Park Jae-Woo , Ko Seok-Jae
Published: October 2022

Objectives: The purpose of this study was to summarize current clinical study trends and results regarding acupuncture treatments for hiccups.Methods: Studies published from 2012 to 2022 were searched on PubMed and domestic databases (OASIS, scienceON, RISS, KISS, KCI) using the keywords “hiccup*”, “singultus”, “singultation”, “hiccupping”, “intractable hiccup*”, “acupuncture”, “auricular acupuncture”, “scalp acupuncture”, “acupuncture point”, “acupoint”, “needle”, “dry needle”, “딸꾹질”, and “침.” The studies were analyzed according to the year, language, study design, characteristics of patients, and acupuncture intervention.Results: In total, 12 studies were selected: 8 case series, 2 case-control studies, and 2 case reports. Manual acupuncture was administered with more than 15 minutes of retention time, most frequently using ST36 and CV12. The acupuncture treatment was effective for hiccup symptoms in all studies, as assessed by clinical symptoms, such as duration time, number of episodes, and recurrence.Conclusions: Acupuncture treatment can be an effective and safe method for treating hiccups and can be used in clinical practice.
Effect of Haegan-jeon on Thioacetamide-Induced Liver Fibrosis
Authors: Choi Jeong Won , Kim Gun Woo , Shin Mi-Rae , Roh Seong-Soo
Published: October 2022

Objective: To investigate the protective effects of Haeganjeon on a thioacetamide (TAA)-induced liver fibrosis mouse model and to determine the Haegan-jeon signaling pathway.Methods: Mice were randomly divided into 4 groups: Normal group (Nor), TAA-induced liver fibrosis group (Con), TAA-induced liver fibrosis group administered 50 mg/kg silymarin (S50), TAA-induced liver fibrosis group administered 200 mg/kg Haegan-jeon (H200). The liver fibrosis mouse model was established by intraperitoneal injection with TAA three times a week for 8 weeks. During the 8 weeks, mice were orally administered silymarin and Haegan-jeon every day. At the end of the study, serum was collected to measure the levels of AST, ALT, ammonia, and myeloperoxidase (MPO). Liver tissue was harvested and analyzed by western blotting and Masson's trichrome staining.Results: Administration of Haegan-jeon suppressed the increase in serum levels of AST, ALT, ammonia, and MPO due to TAA-induced liver fibrosis. Compared to the Con group, the H200 group showed increases in antioxidant-related factors (Nrf2, HO-1, catalase, and GPx-1/2) and decreases in inflammatory-related factors (NF-κB p65, p-IκB-α, Cox-2, iNOS, TNF-α, and IL-1β) in western blots. The H200 treatment inhibited the expression of α-SMA and Collagen I.Conclusions: Haegan-jeon showed a hepatoprotective effect induced by activation of antioxidant-related factors, such as Nrf2, and it regulated the inflammation response by suppression of NF-κB.
A Review of the Stroke Stage and Outcome Measures in Stroke Motor Sequelae Clinical Studies in Korea
Authors: Lee Ji-eun , Chun Se-eun , Jeon Min-gyeol , Shin Yong-jeen , Leem Jung-tae , Shin Sun-ho
Published: October 2022

Objectives: The aims of this study were to evaluate the fidelity of stroke stage reporting, the timeliness of the outcome measures, and the use of the core outcome set.Methods: We searched the literature using 6 domestic databases. We selected studies that used Korean medicine interventions and targeted stroke patients with motor sequelae. We examined whether the included studies reported the stroke stage and whether they used the outcome measures in the appropriate period based on the recommendations of the “Stroke Evidence Database to Guide Effectiveness". We also confirmed the use of the essential assessment tools suggested by the core outcome set.Results: Overall, 77 studies were finally selected, with 16 (21%), 55 (71%), and 6 (8%) published on the acute, subacute, and chronic phases, respectively. Only 11 of the studies directly mentioned the stroke stage. The most commonly used assessments were the National Institutes of Health Stroke Scale, Modified Barthel Index, and Manual Muscle Testing. Only 5 studies failed to apply the stage-related outcome measures at the recommended period. The outcome variables used inadequately were the National Institutes of Health Stroke Scale, Functional Ambulation Categories, 36-Item Short Form Health Survey, and Mini-Mental State Examination. Among the core outcome set items, some studies used liver and renal function tests, but no herbal medicine safety reporting was conducted.Conclusions: In future studies, we propose to ensure accurate reporting of the stroke stage with reliable outcome measures to deliver better clinical and research outcomes. Furthermore, in future clinical studies on stroke, a standard protocol that reflects the core outcome set should be developed.
A Case Report of Persistent Postural-Perceptual Dizziness Treated with Korean Medicine
Authors: Kim Min-hwa , Heo Gi-yoon , Kang Hee-kyung , Nam I-rang , Kim Maria , Lee In , Kwon Jung-nam , Kim So-yeon , Yun Young-ju , Choi Jun-yong , Han Chang-woo , Park So-jung , Hong Jin-woo
Published: October 2022

Objectives: The purpose of this study was to report the effectiveness of Korean medicine in the treatment of persistent postural-perceptual dizziness.Methods: A patient with dizziness was treated with Banhabackchulchunma-tang and Gongjin-dan herbal medicines. The severity of symptoms was assessed with a daily visual analog scale (VAS) for dizziness and the frequency of subjective trembling feelings (over 30 minutes).Results: After the treatment, the severity of dizziness was reduced from VAS 5 to VAS 2, and fatigue was improved from VAS 5 to VAS 1. The frequency of subjective trembling feelings was reduced from once every 3-4 days to once every 10 days. Other symptoms, such as dyspepsia, sleep disturbance, and hot flashes, also showed improvement.Conclusion: Treatment with Korean medicine may be an effective option for the treatment of persistent postural-perceptual dizziness.
Diffusion-tensor magnetic resonance imaging of the growth plates: substantiation of the method and evaluation of its reproducibility
Authors: Brovin D. A. , Trofimova T. N. , Kenis V. M. , Braylov S. A.
Published: October 2022

INTRODUCTION: In recent years there is an increasing interest in assessing the state of the physis among pediatric orthopedic traumatologists, due to the availability of surgical correction of conditions associated with impaired growth plate function. Application of these methods requires dynamic assessment of the state of the physis. The existing methods for assessing the functional state of the physis are few and imperfect. Magnetic resonance imaging (MRI), in particular diffusion tensor imaging (DTI), is promising for assessing the growth plates.

OBJECTIVE: To assess the possibility of applying DTI technique to assess the state of the physis (growth plate).

MATERIALS AND METHODS: The study was approved by the local ethical committee of the Institute of the Human Brain named after N.P. Bekhtereva of Russian Academy of Sciences, protocol No. 32, dated 21.12.2020. Informed consent was obtained from each legal representative. At the Turner National Medical Research Center for Сhildren’s Orthopedics and Trauma Surgery of the Ministry of Health of the Russian Federation a standard magnetic resonance examination of the knee joints was performed, additionally diffusion tensor tomography was performed in 75 patients aged 4.1 to 14.3 years (41 males, 34 females), both deemed healthy and with a known physeal pathology. The studies were performed using a Philips Ingenia ElitionX machine with a magnetic field strength of 3 Tesla, DTI was performed in the coronal plane, TE=71.2 ms, TR=4000 ms, b-factor value 600 s/mm2, 15 diffusion directions were used, slice thickness was 3 mm without gaps, the matrix size was 1.25×1.25 mm. The resulting images were processed using the DSI Studio software, including tract construction, estimation of the total volume and average length of the tracts. The reproducibility of the technique was assessed.

RESULTS: Higher volumes and mean tract lengths were found in healthy males at puberty compared to other groups. When assessing reproducibility, the standard deviations were about 10% of the final value.

DISCUSSION: Images of growth plate tracts were obtained. In individuals of pubertal age that were deemed healthy, the tract volume values and the average length of the tracts were higher than in individuals of prepubertal age and those with pathological conditions affecting the state of the growth plates. The average tract length turned out to be more reproducible than the total tract volume parameter.

CONCLUSION: With the help of DTI, it is possible to evaluate the arrangement of the structures in the growth plates.
Crescimento e Distribuição de renda nos anos do “Milagre econômico”: uma releitura com base nos avanços teóricos na Macroeconomia da Demanda Efetiva
Authors: Rodas Oliveira Bruno , Pinkusfeld Bastos Carlos
Published: October 2022

O artigo faz uma revisão crítica das interpretações sobre o “milagre econômico”, buscando sobretudo sublinhar alguns importantes avanços teóricos dos autores ligados ao recém-criado (à época) Instituto de Economia da Unicamp, bem como questionar aspectos de tais interpretações, com base em avanços mais recentes na macroeconomia da demanda efetiva. Critica-se, neste artigo, interpretações que se tornaram praticamente consensuais, como a que defende que a concentração de renda da época havia sido funcional, ou necessária, ao elevado crescimento econômico, e a de que a capacidade ociosa anterior à aceleração do crescimento teria sido uma condição que favoreceria tal desempenho.
Study on the solid-liquid mass transfer performance of suspension in rotating packed bed
Authors: Liu Bing , Dong Kun , Chen Ru-Jia , Chang Song-Tao , Chu Guang-Wen , Zhang Liang-Liang , Zou Hai-Kui , Sun Bao-Chang
Published: October 2022

This work presents the study on solid-liquid mass transfer performance
of suspension in a rotating packed bed (RPB). The calculation model of
solid-liquid mass transfer coefficient (ks) is deduced on the basis of
the mass conversation law. The ks in RPB is measured using the
suspension of cation exchange resin particle reaction with NaOH. The
effects of different operating parameters such as pre-dispersion time
(t), rotating speed (N), mesh packing thickness (w), liquid volume flow
rate (LT), and solid loading (e) are investigated. The results show that
the ks increases with the increase of N and w, and increases first and
then tends to remain constant with the increase of t and LT. However,
the e has no influence on ks. The obtained ks ranges from 1.00×10-5 m/s
to 2.60×10-4 m/s which is higher than that in microreactor (MR) under
the similar experimental conditions.
Which children are still dying from asthma? A Thirteen Year Review of Pediatric Asthma Deaths in British Columbia, Canada
Authors: Yang Connie , Cook * , Carleton * , Seear *
Published: October 2022

Asthma deaths were rare in children but attention should be paid to
those with a severe exacerbation (requiring systemic steroids, an ED
visit or hospitalization) in the past year, more than three beta-agonist
refills in a year and poor adherence to controller medication.