bluuebunny/crossref_metadata_2025 huggingface dataset:
Metasurfaces integrated with a single-mode waveguide array for off-chip wavefront shaping
Authors: Chen Siyu , Huang Jianzhi , Yin Shengqi , Milosevic Milan M. , Pi Hailong , Yan Jize , Chong Harold M. H. , Fang Xu
Published: April 2023

Integration of metasurfaces and SOI (silicon-on-insulator) chips can leverage the advantages of both metamaterials and silicon photonics, enabling novel light shaping functionalities in planar, compact devices that are compatible with CMOS (complementary metal-oxide-semiconductor) production. To facilitate light extraction from a two-dimensional metasurface vertically into free space, the established approach is to use a wide waveguide. However, the multi-modal feature of such wide waveguides can render the device vulnerable to mode distortion. Here, we propose a different approach, where an array of narrow, single-mode waveguides is used instead of a wide, multi-mode waveguide. This approach tolerates nano-scatterers with a relatively high scattering efficiency, for example Si nanopillars that are in direct contact with the waveguides. Two example devices are designed and numerically studied as demonstrations: the first being a beam deflector that deflects light into the same direction regardless of the direction of input light, and the second being a light-focusing metalens. This work shows a straightforward approach of metasurface-SOI chip integration, which could be useful for emerging applications such as metalens arrays and neural probes that require off-chip light shaping from relatively small metasurfaces.
Space-time wave packets with both arbitrary transverse and longitudinal accelerations
Authors: Liang Zehong , Liu Yejin , Luo Yingjun , Chen Hechong , Deng Dongmei
Published: April 2023

The group velocity in the free space of space-time wave packets (STWPs) and light bullets can be flexibly regulated by many advanced strategies; however, these regulations are restricted to only the longitudinal group velocity. In this work, a computational model based on catastrophe theory is proposed, to devise STWPs with both arbitrary transverse and longitudinal accelerations. In particular, we investigate the attenuation-free Pearcey–Gauss STWP, which enriches the family of non-diffracting STWPs. This work may advance the development of space-time structured light fields.
Light-induced microdroplet suspension and directional self-driving
Authors: Tang Xiaoyun , Song Qinghao , Zhang Zheng , Bai Yang , Zhang Yaxun , Zhang Yu , Liu Zhihai , Yuan Libo
Published: April 2023

In this Letter, we show stable suspension and directional manipulation of microdroplets on a liquid surface employing simple-mode fiber with a Gaussian beam at 1480-nm wavelength using the photothermal effect. The intensity of the light field generated by the single-mode fiber is used to generate droplets of different numbers and sizes. In addition, the effect of the heat generated at different heights from the liquid surface is discussed through numerical simulation. In this work, the optical fiber is not only free to move at any angle, solving the difficulty that a certain working distance is needed to generate microdroplets on free space, it can also allow the continuous generation and directional manipulation of multiple microdroplets, which is of tremendous scientific relevance and application value in promoting the development and cross-fertilization of life sciences and other interdisciplinary fields.
Genomic surveillance uncovers a pandemic clonal lineage of the wheat blast fungus
Authors: Latorre Sergio M. , Were Vincent M. , Foster Andrew J. , Langner Thorsten , Malmgren Angus , Harant Adeline , Asuke Soichiro , Reyes-Avila Sarai , Gupta Dipali Rani , Jensen Cassandra , Ma Weibin , Mahmud Nur Uddin , Mehebub Md. Shabab , Mulenga Rabson M. , Muzahid Abu Naim Md. , Paul Sanjoy Kumar , Rabby S. M. Fajle , Rahat Abdullah Al Mahbub , Ryder Lauren , Shrestha Ram-Krishna , Sichilima Suwilanji , Soanes Darren M. , Singh Pawan Kumar , Bentley Alison R. , Saunders Diane G. O. , Tosa Yukio , Croll Daniel , Lamour Kurt H. , Islam Tofazzal , Tembo Batiseba , Win Joe , Talbot Nicholas J. , Burbano Hernán A. , Kamoun Sophien
Published: April 2023

Wheat, one of the most important food crops, is threatened by a blast disease pandemic. Here, we show that a clonal lineage of the wheat blast fungus recently spread to Asia and Africa following two independent introductions from South America. Through a combination of genome analyses and laboratory experiments, we show that the decade-old blast pandemic lineage can be controlled by the Rmg8 disease resistance gene and is sensitive to strobilurin fungicides. However, we also highlight the potential of the pandemic clone to evolve fungicide-insensitive variants and sexually recombine with African lineages. This underscores the urgent need for genomic surveillance to track and mitigate the spread of wheat blast outside of South America and to guide preemptive wheat breeding for blast resistance.
Profiling of metabolites, proteins, and protein phosphorylation in silica-exposed BEAS-2B epithelial cells
Authors: Chen Jin , Wang Hanshi , Gao Hongzhi , Zeng Yiming
Published: April 2023

Silicosis is an uncurable occupational disease induced by crystalline silica. Increased prevalence of silicosis has resulted in the increased need for development of treatment options. Although macrophages respond first to silica, epithelial cells are also involved in silicosis. However, changes in protein and metabolite levels have not been reported simultaneously. We used mass spectrometry to profile changes in metabolites, proteins, and phosphorylation in silica-exposed BEAS-2B epithelial cells. Silica exposure increased TCA cycle, alanine, aspartate and glutamate metabolism, and aerobic glycolysis activity. In addition, protein levels in the endoplasmic reticulum were significantly altered, and phosphorylation of MAPK signaling proteins was increased. The results of this study increased understanding the role of epithelial cells in silicosis.
Supervisors’ ethical leadership and graduate students’ attitudes toward academic misconduct
Authors: Zhang Guangxi , Zhang Tingting , Mao Sunfan , Xu Qiang , Ma Xiaoqin
Published: April 2023

Graduate students’ academic misconduct has received increasing attention. Although past literature has emphasized university faculty as an important influencing factor on students’ moral behaviors, the mechanisms must be further disclosed. We investigated how supervisors’ ethical leadership influenced graduate students’ attitudes toward academic misconduct. We explained why and how supervisor gender affects post-graduate students’ social learning process by integrating social cognitive theory and role congruity theory. Study 1 used a sample of 301 graduate students in 60 academic teams in four Chinese business schools. Study 2 used experimental vignette methodology to enhance the findings’ internal and external validity and provided evidence of causality. Based on the two complementary studies, we found that supervisors’ ethical leadership significantly inhibited students’ acceptance of academic misconduct through students’ moral efficacy and the ethical climate of the academic team. The indirect effect via moral efficacy was more significant s for female supervisors. Implications for ethical leadership, academic misconduct, gender differences in leadership, and moral education were discussed.
Testosterone treatment combined with exercise to improve muscle strength, physical function and quality of life in men affected by inclusion body myositis: A randomised, double-blind, placebo-controlled, crossover trial
Authors: Connor Sophia G. , Fairchild Timothy J. , Learmonth Yvonne C. , Beer Kelly , Cooper Ian , Boardman Glenn , Teo Shaun Y. M. , Shatahmasseb Behnaz , Zhang Rui , Hiscock Krystyne , Coudert Jerome D. , Yeap Bu B. , Needham Merrilee
Published: April 2023

Introduction

Inclusion body myositis (IBM) is the most commonly acquired skeletal muscle disease of older adults involving both autoimmune attack and muscle degeneration. As exercise training can improve outcomes in IBM, this study assessed whether a combination of testosterone supplementation and exercise training would improve muscle strength, physical function and quality of life in men affected by IBM, more than exercise alone.

Methods

This pilot study was a single site randomised, double-blind, placebo-controlled, crossover study. Testosterone (exercise and testosterone cream) and placebo (exercise and placebo cream) were each delivered for 12 weeks, with a two-week wash-out between the two periods. The primary outcome measure was improvement in quadriceps isokinetic muscle strength. Secondary outcomes included assessment of isokinetic peak flexion force, walk capacity and patient reported outcomes, and other tests, comparing results between the placebo and testosterone arms. A 12-month Open Label Extension (OLE) was offered using the same outcome measures collected at 6 and 12-months.

Results

14 men completed the trial. There were no significant improvements in quadriceps extension strength or lean body mass, nor any of the secondary outcomes. Improvement in the RAND Short Form 36 patient reported outcome questionnaire ‘emotional wellbeing’ sub-category was reported during the testosterone arm compared to the placebo arm (mean difference [95% CI]: 6.0 points, [95% CI 1.7,10.3]). The OLE demonstrated relative disease stability over the 12-month period but with a higher number of testosterone-related adverse events.

Conclusions

Adding testosterone supplementation to exercise training did not significantly improve muscle strength or physical function over a 12-week intervention period, compared to exercise alone. However, the combination improved emotional well-being over this period, and relative stabilisation of disease was found during the 12-month OLE. A longer duration trial involving a larger group of participants is warranted.
Static anti-windup compensator design for locally Lipschitz systems under input and output delays
Authors: Hameed Muhammad Jazib , Rehan Muhammad , Iqbal Muhammad , Hussain Muntazir , Saqib Najam us , Iqbal Jamshed
Published: April 2023

This paper proposes a static anti-windup compensator (AWC) design methodology for the locally Lipschitz nonlinear systems, containing time-varying interval delays in input and output of the system in the presence of actuator saturation. Static AWC design is proposed for the systems by considering a delay-range-dependent methodology to consider less conservative delay bounds. The approach has been developed by utilizing an improved Lyapunov-Krasovskii functional, locally Lipschitz nonlinearity property, delay-interval, delay derivative upper bound, local sector condition,L2gain reduction from exogenous input to exogenous output, improved Wirtinger inequality, additive time-varying delays, and convex optimization algorithms to obtain convex conditions for AWC gain calculations. In contrast to the existing results, the present work considers both input and output delays for the AWC design (along with their combined additive effect) and deals with a more generic locally Lipschitz class of nonlinear systems. The effectiveness of the proposed methodology is demonstrated via simulations for a nonlinear DC servo motor system, possessing multiple time-delays, dynamic nonlinearity and actuator constraints.
The five influencing factors of tourist loyalty: A meta-analysis
Authors: Wang Lidong , Li Xiuhong
Published: April 2023

Background

The factors influencing tourist loyalty are widely highlighted in the literature. However, we find that the relationship between some influencing factors and loyalty is still inconsistent, and we don’t yet know the strength and magnitude of the relationships. To address this issue, this study examined a meta-analysis of the five factors (satisfaction, motivation, perceived value, perceived quality, and experience quality) influencing tourist loyalty and its sub-dimensions.

Methods

The samples included articles from major academic databases, including Web of Science, Wiley Online, EBSCO, SAGE, Taylor and Francis, and Elsevier. Studies written in Chinese were retrieved from CNKI.com. We used the following keywords for retrieval: loyalty, behavioral intention, recommendation intention, word-of-mouth, revisit intentions, intention to revisit, willingness to recommend, and similar related terms. Conceptual and empirical studies published between January 1989 and September 2021 were extracted. To test whether there was publication bias, we used Fail-Safe-Number (FSN) to verify the stability of the results. The homogeneity test of the selected statistical model was based on the Q test and I2. The results were obtained by combining multiple single effect values into the combined effect value.

Results

We developed 21 hypotheses and proposed a theoretical framework and analyzed 114650 accumulated sample sizes from 242 independent empirical studies. Among the 21 hypotheses proposed in this paper, the remaining 20 hypotheses have been proved except for hypothesis H6.

Conclusions

The findings showed that the five factors had varying degrees of positive and significant relationships with tourist loyalty and its sub-dimensions. In the descending order of effects, the five factors are degree of satisfaction, quality of experience, perceived value, perceived quality and motivation. We discussed the significance of the meta-analysis, theoretical and practical implications for destination marketing.
Adeno-Associated virus 8 delivers an immunomodulatory peptide to mouse liver more efficiently than to rat liver
Authors: Wang Yuqing , Hurley Ayrea , De Giorgi Marco , Tanner Mark R. , Hu Rong-Chi , Pennington Michael W. , Lagor William R. , Beeton Christine
Published: April 2023

Targeting the Kv1.3 potassium channel has proven effective in reducing obesity and the severity of animal models of autoimmune disease. Stichodactyla toxin (ShK), isolated from the sea anemone Stichodactyla helianthus, is a potent blocker of Kv1.3. Several of its analogs are some of the most potent and selective blockers of this channel. However, like most biologics, ShK and its analogs require injections for their delivery, and repeated injections reduce patient compliance during the treatment of chronic diseases. We hypothesized that inducing the expression of an ShK analog by hepatocytes would remove the requirement for frequent injections and lead to a sustained level of Kv1.3 blocker in the circulation. To this goal, we tested the ability of Adeno-Associated Virus (AAV)8 vectors to target hepatocytes for expressing the ShK analog, ShK-235 (AAV-ShK-235) in rodents. We designed AAV8 vectors expressing the target transgene, ShK-235, or Enhanced Green fluorescent protein (EGFP). Transduction of mouse livers led to the production of sufficient levels of functional ShK-235 in the serum from AAV-ShK-235 single-injected mice to block Kv1.3 channels. However, AAV-ShK-235 therapy was not effective in reducing high-fat diet-induced obesity in mice. In addition, injection of even high doses of AAV8-ShK-235 to rats resulted in a very low liver transduction efficiency and failed to reduce inflammation in a well-established rat model of delayed-type hypersensitivity. In conclusion, the AAV8-based delivery of ShK-235 was highly effective in inducing the secretion of functional Kv1.3-blocking peptide in mouse, but not rat, hepatocytes yet did not reduce obesity in mice fed a high-fat diet.
Spatial variations and determinants of malnutrition among under-five children in Nigeria: A population-based cross-sectional study
Authors: Amusa Lateef Babatunde , Yahya Waheed Babatunde , Bengesai Annah Vimbai
Published: April 2023

Childhood undernutrition is a major public health challenge in sub-Saharan Africa, particularly Nigeria. Determinants of child malnutrition may have substantial spatial heterogeneity. Failure to account for these small area spatial variations may cause child malnutrition intervention programs and policies to exclude some sub-populations and reduce the effectiveness of such interventions. This study uses the Composite Index of Anthropometric Failure (CIAF) and a geo-additive regression model to investigate Nigeria’s prevalence and risk factors of childhood undernutrition. The geo-additive model permits a flexible, joint estimation of linear, non-linear, and spatial effects of some risk factors on the nutritional status of under-five children in Nigeria. We draw on data from the most recent Nigeria Demographic and Health Survey (2018). While the socioeconomic and environmental determinants generally support literature findings, distinct spatial patterns were observed. In particular, we found CIAF hotspots in the northwestern and northeastern districts. Some child-related factors (Male gender: OR = 1.315; 95% Credible Interval (CrI): 1.205, 1.437) and having diarrhoea: OR = 1.256; 95% CrI: 1.098, 1.431) were associated with higher odds of CIAF. Regarding household and maternal characteristics, media exposure was associated with lower odds of CIAF (OR = 0.858; 95% CrI: 0.777, 0.946). Obese maternal BMI was associated with lower odds of CIAF (OR = 0.691; 95% CrI: 0.621, 0.772), whereas, mothers classified as thin were associated with higher odds of CIAF (OR = 1.216; 95% CrI: 1.055, 1.411). Anthropometric failure is highly prevalent in Nigeria and spatially distributed. Therefore, localised interventions that aim to improve the nutritional status of under-five children should be considered to avoid the under-coverage of the regions that deserve more attention.
Evaluation of psychometric properties of perceived value applied to universities
Authors: Amado-Mateus Marelby , Cuero-Acosta Yonni Angel , Guzman-Rincón Alfredo
Published: April 2023

Over the past 20 years, the construct of perceived value has been the subject of much research, most of it applied to the service sector. The intangible nature of this sector requires an in-depth analysis of customer perceptions of what they give and what they receive. In this research, perceived value is applied in the context of higher education, where perceived quality faces several challenges and has a tangible component that is related to their experience when receiving the educational service, and an intangible component that is related to the image and reputation of the university. One of these challenges is the increasingly competitive environment of universities, so it is important to understand what factors influence students’ perception of value. For this purpose, several scales of perceived value were reviewed and one was selected and its psychometric properties were evaluated. For this evaluation, cultural adaptation techniques, exploratory factor analysis and confirmatory factor analysis were used. The statistical results showed the validity and reliability of the scale applied to universities in the Colombian context.
Recovery & Safety: What to Look Out For
Authors: Guntupalli Lohitha , Martin Gabriella , Kammerman Jay , Lambert Evan , Piotrowska Agata , Collins Dylon , Bronk Thomas , Homolka Lauren , Bouchard Stephanie
Published: April 2023

This trifold brochure, created by a cohort of third-year medical students during their clinical clerkships, providesinformation on recovery and safety measures following a hurricane. The brochure was designed in response to the aftermath of Hurricane Ian and distributed to local health departments and free clinics in the Port Charlotte and Punta Gorda Area. The brochure was specifically developed to be easily understood by the layman.

This trifoldcontains important tips on food and water safety, medical advice for animal and insect bites, and alternative sources of fuel and electricity. Additionally, it provides crucial contact information for trauma and disaster coping.

As a reliable resource, this public health brochure is intended to assist those affected by natural disasters and to promote safety and recovery efforts in communities.
Planning Learning Activities and Teaching Methods for Improving Inference Comprehension Ability
Authors:   Center For Educational Research, Seo Jiyoung , Park Youngmin
Published: April 2023

Purpose: Inferential comprehension plays a central role in the process of reading comprehension. In order to improve this inference ability, it is necessary to establish a teaching and learning plan thateffectively reflects the thinking base of inference, and to implement learning activities appropriately. Methods: In order to plan learning activities for improving inference comprehension ability, we graspedthe concept and types of inference comprehension, and the stylistic characteristics of newspaper articlesthat can be used as learning materials. Results: Combining stylistic elements such as headlines and subtitles of newspaper articles, specializations,texts, and types of reasoning, learning activities and teaching strategies for improving reasoningcomprehension ability were devised. Conclusion: Headlines and subtitles of newspaper articles are sufficient as clues for reasoning asteaching and learning materials for improving deductive comprehension ability. Learning activities usingthe headlines and subtitles of newspaper articles can be typed according to the direction of reasoning,the scope of reasoning, and the method of reasoning. Specifically, forward reasoning and backwardreasoning, core content reasoning and supporting content reasoning, background knowledge and articlecontent utilization reasoning, and other areas. can be classified as typing categories. Newspaper articles,in addition to their unique stylistic elements such as headlines and subtitles, are highly utilized interms of access to reading, interest and motivation as reading materials closely related to daily life. Therefore, it can be an efficient way to improve the reasoning comprehension ability by activelyutilizing this to plan learning activities and to construct teaching plans.
OUTORGAS DE USO DOS RECURSOS HÍDRICOS NA ÁREA DE PROTEÇÃO AMBIENTAL DO RIO MACHADO, SUL DE MINAS GERAIS
Authors: Latuf Marcelo de Oliveira , Chinen Hanna Sayuri de Souza , Musselli Denis Giovanni , Carvalho Pedro Henrique Silva
Published: April 2023

A outorga de água é um ato administrativo previsto pela Política Nacional de Recursos Hídricos, que concede ao solicitante o direito de uso dos recursos hídricos, vinculando diretrizes do plano de bacias, garantindo o uso múltiplo do mesmo. A Área de Proteção Ambiental da Bacia Hidrográfica do rio Machado, localizada no Sul de Minas Gerais, possui um mosaico de intenso uso da terra, demandando água para diversos processos produtivos. Objetiva-se avaliar por este artigo as concessões das outorgas emitidas pelo Instituto Mineiro de Gestão das Águas para a APA do rio Machado no período entre 2002 a 2018. Para a realização desta pesquisa utilizaram-se dados cartográficos obtidos nas cartas topográficas na escala de 1:50.000, dados do Instituto Estadual de Florestas de Minas Gerais, bem como a base de dados sobre outorgas do Instituto Mineiro de Gestão das Águas. Os tratamentos de dados espaciais e não-espaciais foram realizados via sistema de informação geográfica, planilhas eletrônicas e pelos aplicativos do software R. Resultados demonstram que há incremento nas concessões de outorgas na APA do rio Machado a partir de 2014, sendo que as maiores densidades de outorgas expedidas se encontram no médio e baixo rio Machado, em virtude da agricultura irrigada, que utiliza 70,8% das vazões consumidas.
MAPEAMENTO DO PERIGO DE INUNDAÇÃO EM BACIA URBANA COM POUCOS DADOS HIDROLÓGICOS
Authors: Lopes Carolina Bastos Marques , Dourado Francisco , Souza Lucio Silva de
Published: April 2023

Eventos extremos de chuva e cidades não planejadas reforçam a importância do mapeamento das inundações urbanas. Por outro lado, dados espaciais e meteorológicos disponibilizados por agências governamentais, não são compatíveis com o estudo de inundações e assim criam um cenário escasso de dados efetivamente medidos. Dessa forma, o presente trabalho objetiva mapear o perigo de inundações para bacia hidrográfica urbana (Rio Botas, Nova Iguaçu, Rio de Janeiro) com poucos dados disponíveis. O mapeamento é realizado por meio de modelos hidrológico e hidrodinâmico. Como a referida bacia não possui estação pluviométrica com série histórica robusta é implementada uma metodologia para selecionar uma estação representativa no seu entorno, sendo essa a estação meteorológica Ecologia Agrícola. O regime de chuva encontrado no estudo é compatível com os cenários de alerta da Defesa Civil, o que sugere que a metodologia é válida, nesse caso. Com relação às modelagens, independente da ausência de dados mais específicos o resultado foi considerado satisfatório, pois na validação empírica os pontos alagados foram os mesmos apresentados pelos agentes da Defesa Civil. Sendo assim, os resultados obtidos demonstram que é possível realizar um mapeamento de inundação satisfatório mesmo em bacias hidrográficas com escassez de dados.
INCORPORAÇÃO IMOBILIÁRIA E INTERVENÇÕES PÚBLICAS NA ORLA MARÍTIMA DE FORTALEZA/CE
Authors: Tavares Isabella Freires , Pereira Alexandre Queiroz , Silva Anderson da Cruz
Published: April 2023

As orlas urbanas marítimas são constantemente remodeladas e reestruturadas para se adequarem à incessante necessidade de reprodução do capital, onde determinados agentes sociais possuem maior poder de influência sobre a produção do espaço. O presente artigo propõe a análise do poder público municipal como principal agente produtor e articulador desse processo a partir da investigação de intervenções atribuídas à orla de Fortaleza/CE, através do uso de instrumentos urbanísticos como a Operação Urbana Consorciada e a Outorga Onerosa. Nesse contexto, sobre as transformações urbanas específicas da porção central-leste, constatou-se que, apesar dos discursos sobre contribuição social e a inclusão da participação popular nas tomadas de decisões, demonstra-se que os interesses de múltiplos agentes, no âmbito público e/ou privado, orientam-se à sustentação e à expansão da atuação da incorporação imobiliária aliadas ao turismo internacional e ao marketing político. O resultado é a crescente valorização da orla e a consolidação da moradia de mais alto padrão da cidade associados ao aumento da verticalização frente ao mar.
CONTRIBUIÇÕES DA CARTOGRAFIA GEOMORFOLÓGICA AO PLANEJAMENTO DO USO E OCUPAÇÃO DA TERRA: APLICAÇÕES NO MUNICÍPIO DE ANTÔNIO GONÇALVES - BA
Authors: Reis Felipe de Souza , Souza Sírius Oliveira
Published: April 2023

O estudo das formas de relevo compõe o campo da Geomorfologia, e apresenta sua eficácia perante a necessidade de entendimento da dinâmica dos processos naturais no esculpimento das formas e na consequente ocupação dessas formas. Assim, uma das principais formas de análise dos ambientes naturais é por meio da Cartografia Geomorfológica, entendida como campo de representação das formas do relevo. Dessa forma, este trabalho tem o objetivo de propor o mapeamento geomorfológico do município de Antônio Gonçalves (BA), enquanto subsídio ao planejamento do uso e ocupação da terra, com base na metodologia do IBGE (2009). Para tanto, o trabalho foi dividido em quatro etapas; a primeira composta de revisão bibliográfica; a segunda, pelo uso de fotografias aéreas; a terceira definida pelo cálculo do índice de dissecação e elaboração dos resultados e discussões. Identificou-se o predomínio de formas relacionadas aos Modelados de Acumulação, como as planícies aluviais, Modelados de aplainamento, como o pedimento, e Modelados de Dissecação, representado pelas cristas assimétricas e vales estruturais. Essa pesquisa manifesta questões preocupantes, ao identificar compartimentos do relevo com alto índice de dissecação, ao passo que direciona, ao evidenciar a necessidade dos planejamentos geotécnicos e da Lei de parcelamento do solo urbano (BRASIL,1979).
Approximation of the image of the L

p
ball under Hilbert-Schmidt integral operator
Authors: Huseyin Nesir
Published: April 2023

In this article, an approximation of the image of the closed ball of the space

L

p

{L}_{p}

(

p
>
1

p\gt 1

) centered at the origin with radius

r

r

under Hilbert-Schmidt integral operator

F

(

⋅

)

:

L

p

→

L

q

F\left(\cdot ):{L}_{p}\to {L}_{q}

,

1

p

+

1

q

=
1

\frac{1}{p}+\frac{1}{q}=1

is considered. An error evaluation for the given approximation is obtained.
Directionality in the psych alternation: a quantitative cross-linguistic study
Authors: Rott Julian Andrej , Verhoeven Elisabeth , Fritz-Huechante Paola
Published: April 2023

Languages display global preferences for transitive, intransitive or underspecified roots in their verbal lexicon and correspondingly for the use of processes for deriving related concepts with different valency (cf. Nichols, Johanna, David A. Peterson & Jonathan Barnes. 2004. Transitivizing and detransitivizing languages. Linguistic Typology 8. 149–211). This classification is particularly relevant when applied to psych verbs, since variable linking is a widely recognized feature of this domain. This paper reports on the results of a larger typological study, involving 26 languages from 15 language families, aimed at investigating directionality in the psych alternation. In our data, most languages show preferences for one of the alternation strategies (augmented, reduced, undirected) which is then pervasive in their psych inventory, while the alternative patterns are marginally represented. Furthermore, the Indo-European languages of Europe stand out in being detransitivizing in the psych domain whereas transitivizing and underspecified languages do not show areal patterns. Moreover, we found a significant impact of alignment type on the occurrence of alternation strategies to the effect that reducing strategies are significantly less frequent in languages with ergative traits compared to languages without ergative traits. Our data also showed a positive effect of alignment in the undirected strategies meaning that undirected pairs are significantly more frequent in languages with ergative traits.
Cell division protein FtsK coordinates bacterial chromosome segregation and daughter cell separation in Staphylococcus aureus
Authors: Veiga Helena , Jousselin Ambre , Schäper Simon , Saraiva Bruno M , Marques Leonor B , Reed Patricia , Wilton Joana , Pereira Pedro M , Filipe Sérgio R , Pinho Mariana G
Published: April 2023

Unregulated cell cycle progression may have lethal consequences and therefore, bacteria have various mechanisms in place for the precise spatiotemporal control of cell cycle events. We have uncovered a new link between chromosome replication/segregation and splitting of the division septum. We show that the DNA translocase domain‐containing divisome protein FtsK regulates cellular levels of a peptidoglycan hydrolase Sle1, which is involved in cell separation in the bacterial pathogen Staphylococcus aureus. FtsK interacts with a chaperone (trigger factor, TF) and establishes a FtsK‐dependent TF concentration gradient that is higher in the septal region. Trigger factor binds Sle1 and promotes its preferential export at the septal region, while also preventing Sle1 degradation by the ClpXP proteolytic machinery. Upon conditions that lead to paused septum synthesis, such as DNA damage or impaired DNA replication/segregation, TF gradient is dissipated and Sle1 levels are reduced, thus halting premature septum splitting.
Dedifferentiation‐derived neural stem cells exhibit perturbed temporal progression
Authors: Veen Kellie , Nguyen Phuong‐Khanh , Froldi Francesca , Dong Qian , Alvarez‐Ochoa Edel , Harvey Kieran F , McMullen John PD , Marshall Owen , Jusuf Patricia R , Cheng Louise Y
Published: April 2023

Dedifferentiation is the reversion of mature cells to a stem cell‐like fate, whereby gene expression programs are altered and genes associated with multipotency are (re)expressed. Misexpression of multipotency factors and pathways causes the formation of ectopic neural stem cells (NSCs). Whether dedifferentiated NSCs faithfully produce the correct number and types of progeny, or undergo timely terminal differentiation, has not been assessed. Here, we show that ectopic NSCs induced via bHLH transcription factor Deadpan (Dpn) expression fail to undergo appropriate temporal progression by constantly expressing mid‐temporal transcription factor(tTF), Sloppy‐paired 1/2 (Slp). Consequently, this resulted in impaired terminal differenation and generated an excess of Twin of eyeless (Toy)‐positive neurons at the expense of Reversed polarity (Repo)‐positive glial cells. Preference for a mid‐temporal fate in these ectopic NSCs is concordant with an enriched binding of Dpn at mid‐tTF loci and a depletion of Dpn binding at early‐ and late‐tTF loci. Retriggering the temporal series via manipulation of the temporal series or cell cycle is sufficient to reinstate neuronal diversity and timely termination.
Analisis Produksi Microgreens Brassica oleracea Berinovasi Urban Gardening Untuk Peningkatan Mutu Pangan Nasional
Authors: Febriani Vina , Nasrika Evy , Munasari Tri , Permatasari Yoan , Widiatningrum Talitha
Published: April 2023

Peningkatan jumlah penduduk membuat lahan yang tersedia menjadi semakin sempit, hal ini berdampak pada kurangnya lahan yang tersedia untuk menanam tanaman karena tergusur oleh kebutuhan pemukiman, masyarakat membutuhkan tanaman organik sebagai bahan untuk dikonsumsi. â€œMba-Geningâ€ : Microgreens Brassica oleracea Berinovasi Urban Gardening hadir sebagai salah satu solusi minimnya lahan untuk menanam. Microgreens adalah tanaman herba yang dipanen di usia muda, yaitu 10-14 hari atau setelah melewati proses perkecambahan. Tanaman microgreens biasa dipanen dengan tinggi 5-7,5 cm. Microgreens dibudidayakan padaÂ trayÂ khusus dengan media tanam. Benih microgreens di sebar ke media tanam, diberi air dan di-sprayÂ 1-2 kali sehari untuk pertumbuhannya. Microgreens memiliki kandungan nutrisi lebih banyak dari pada sayuran hijau yang dipanen saat dewasa, yaitu mencapai hingga 6 kali lipatnya. Microgreens dapat dikonsumsi secara langsung tanpa dimasak, umumnya, digunakan sebagaiÂ garnishÂ atau hiasan pada masakan di restoran, sepertiÂ steakÂ dan sup, dapat pula dikonsumsi sebagai salad dan isianÂ sandwich. Produksi Mba-Gening dapat menjawab kebutuhan masyarakat akan sayur organik khususnya brokoli, selain itu juga membuang peluang usaha yang baik karena memiliki target pasar yang luas serta belum ada kompetitor di pasaran. Produksi dan teknik pemasaran yang baik dapat meningkatkan hasil dari usaha ini. Kedepannya, produk akan ditingkatkan kualitasnya sesuai dengan kebutuhan konsumen agar kepuasan konsumen semakin meningkat.
Young Scientia Community and Pancasila Moral Integrity
Authors: Rahmawati Ega
Published: April 2023

Pancasila is the ideology, guideline and basis of the Indonesian state. The five precepts of Pancasila are the embodiment of the basic values that come from real values in people's lives. Pancasila as a guideline for the community in carrying out an action and can be used as a rejection of values that are not in accordance with the Pancasila. In the development of today's society, the term millennial generation appears. Millennial generation is a generation born of the rapid development of Technology and Communication Sciences. Millennials include generation Y where in every life can not be separated from the influence of technology in various fields of life. But in reality, millennial geners in Indonesia are increasingly alarming. There are various problems facing the current millennial generation which are the challenges of the Pancasila in dealing with them. Such as the anti-social attitude, the influence of hoaxes, and the influence of hedonism on the millennial generation which is a deviation from the implementation of the Pancasila.
Implementation of Pancasila Values on the Character of Environmental Concern in the Life of Islamic Boarding Schools
Authors: Savitri Yulia Ayu
Published: April 2023

The living environment is the human habitation of everyday life. As the successor generation of the nation, must be embedded values Pancasila high environmental social concern. Environmental conditions have an effect on everyday activities. In addition, the implementation of Pancasila values is very important for the environmental conservation of Pesantren. The common problem is the lack of awareness of environmental hygiene resulting in the onset of viral diseases. Not only that, lack of control and supervision of the caretaker Pondok Pesantren also affects. Diseases that attack are usually mild diseases, such as flu, fever, and others. But there are also infectious diseases and causes of death. From this problem, students who have infectious diseases will be difficult to overcome. Because students ' life is identic with togetherness or interdependence with one another. The method used is a qualitative approach by using stages of observation, observation, interviews. This Model of research is not only to analyse internal life in the cottage environment, but also the life of an extense involving problems in the cottage environment. From this research obtained the result that it takes socialization or appeal for students to maintain the environment by raising awareness of the importance of clean and healthy environment. And provide information about the variety of creativity that can be utilized for items that are not used.
Reactualization of Pancasila in Preventing Radicalism and Terrorism
Authors: Mujib Muhammad Abdul
Published: April 2023

Practicing the values of Pancasila for the nation's young generation must be improved. In the present era, it can be felt if the values of the Pancasila are gradually eroded due to the influence of the current era. Pancasila values are not reflected in a part of Indonesian society as seen from several problems that have emerged lately such as radicalism and terrorism. The emergence of radicalism and terrorism threatens the ideology and soul of the Unitary State of the Republic of Indonesia. There needs to be a personal drive from the outside and inside the nation to overcome the problem. Pancasila reactualization for the younger generation is one of the keys in counteracting radicalism and terrorism. The acts of radicalism and terrorism have an impact on division, loss of diversity and fear for all Indonesian citizens. This research is normative research, the object of study is Pancasila, and the method used in this study is literature study.Practicing the values of Pancasila for the nation's young generation must be improved. In the present era, it can be felt if the values of the Pancasila are gradually eroded due to the influence of the current era. Pancasila values are not reflected in a part of Indonesian society as seen from several problems that have emerged lately such as radicalism and terrorism. The emergence of radicalism and terrorism threatens the ideology and soul of the Unitary State of the Republic of Indonesia. There needs to be a personal drive from the outside and inside the nation to overcome the problem. Pancasila reactualization for the younger generation is one of the keys in counteracting radicalism and terrorism. The acts of radicalism and terrorism have an impact on division, loss of diversity and fear for all Indonesian citizens. This research is normative research, the object of study is Pancasila, and the method used in this study is literature study.
The Role of Pancasila as an Open Ideology
Authors: Febriyanto Mugi
Published: April 2023

The purpose of the discussion of this article is to explain the role of Pancasila as the ideology of the open nation of Indonesia. Pancasila is the foundation of the ideology of the Indonesian state, where Pancasila is a reflection of the values and goals of the Indonesian nation. nationally. Along with the era of globalization Pancasila has become a middle ground in solving problems that are developing in today's society. The rapid development of socio-culture, Pancasila as a filtering of incoming developments, Pancasila is wide open to global developments in deviant matters. towards global development is very important, because the essence of Pancasila is an important ideology.
Legal Analysis of Legal Personality Organization of South East Asian Countries (ASEAN) as the Subject of International Law
Authors: Satesna Dhezya Pandu
Published: April 2023

ASEAN stands on August 8, 1967, under the agreement of five foreign ministers of Southeast Asian Countries namely Adam Malik (Indonesia), Tun Abdul Razak (Malaysia), Thanat Khoman (Thailand), Rajaratnam (Singapore), and Narcisco Ramos (Philippines). The ASEAN Charter is the legal and institutional framework that binds all ASEAN member countries and makes ASEAN an organization of legal status. ASEAN has immunities and privileges in the territory of the Member States as necessary to achieve its objectives. ASEAN with the ASEAN Charter being a full international organization, there are clear rules on ASEAN. Among them are the privileges and immunities for Permanent Representatives and diplomatic diplomatic agents in the ASEAN Secretariat.
Impact and Law Enforcement of Vigilante in the Society
Authors: Margareta Veronica Sherly , Waspiah Waspiah
Published: April 2023

This study aims to determine: the meaning of vigilante action or eigenrechting, the impact that can be caused by vigilante action and, law enforcement against vigilante action in society. This research is included in the type of qualitative research which is a literature study (Library Research) which uses journals as reading references. The method used is descriptive analysis by providing clear, objective, systematic, analytical and critical descriptions and information regarding the impact and law enforcement of self-play in the community. The data used in this study is secondary data whose material is sourced from legal journals. The act of vigilantism is a translation of the word from the Dutch language, namely "Eigenrichting" which is defined as a way of taking vigilantes which is carried out by taking rights without heeding applicable laws, without the knowledge of the government and without the use of tools on the government's power. Violence often coexists with violations of the rights of others. Acts of vigilantism can have an impact on many parties such as victims of mis-targeting, perpetrators of crimes who are victims, the community, crime rates, even those who take part in taking vigilante action are also affected by their actions which can be punished according to their actions. what he has done. Punishments that can ensnare perpetrators of vigilante action have been regulated in the Criminal Code, namely Article 170 of the Criminal Code which regulates legal sanctions for perpetrators who commit acts of violence against people or goods in public, Article 351 of the Criminal Code regarding acts of persecution and Article 55 of the Criminal Code regarding participating in acts of violence. and in doing an action.
A unique melanocortin-4-receptor signaling profile for obesity-associated constitutively active variants
Authors: Botha Rikus , Kumar Shree S , Grimsey Natasha L , Mountjoy Kathleen G
Published: April 2023

The melanocortin-4 receptor (MC4R) plays a critical role in regulating energy homeostasis. Studies on obesogenic human MC4R (hMC4R) variants have not yet revealed how hMC4R maintains body weight. Here, we identified a signaling profile for obesogenic constitutively active H76R and L250Q hMC4R variants transfected in HEK293 cells that included constitutive activity for adenylyl cyclase (AC), cyclic adenosine monophosphate (cAMP) response element (CRE)-driven transcription, and calcium mobilization but not phosphorylated extracellular signal-regulated kinase 1/2 (pERK1/2) activity. Importantly, the signaling profile included impaired α-melanocyte-stimulating hormone-induced CRE-driven transcription but not impaired α-melanocyte-stimulating hormone-induced AC, calcium, or pERK1/2. This profile was not observed for transfected H158R, a constitutively active hMC4R variant associated with overweight but not obesity. We concluded that there is potential for α-melanocyte-stimulating hormone-induced CRE-driven transcription in HEK293 cells transfected with obesogenic hMC4R variants to be the key predictive tool for determining whether they exhibit loss of function. Furthermore, in vivo, α-melanocyte-stimulating hormone-induced hMC4R CRE-driven transcription may be key for maintaining body weight.
Una aproximación al estudio de las relaciones internacionales en los albores del siglo XVIII: la contienda sucesoria y los embajadores hispánicos en Versalles (1700-1714)
Authors: Gómez Mesas Javier
Published: April 2023

A lo largo de las siguientes líneas pretendemos ahondar en la comprensión de las relaciones internacionales, analizando la paulatina gestación de un cuerpo burocrático encargado de administrar las cuestiones diplomáticas y la progresiva profesionalización de los emisarios. Para tratar de comprender nuestro objeto de estudio, proponemos una revisión bibliográfica sobre los emisarios hispánicos destinados a la corte versallesca durante la contienda sucesoria, resaltando el profundo vacío historiográfico que pesa sus trayectorias y ponderando las limitaciones con las que pudieron contar a la hora de desempeñar sus legaciones. A pesar de los escasos estudios existentes, podemos constatar que la representación exterior de la monarquía hispánica no se mantuvo aparte de los procesos que se gestaban allende y concurrió de forma activa en Versalles. Una participación que fue vital en el sostén de las pretensiones dinásticas de Felipe V y la coordinación de los esfuerzos de una guerra internacional que dirimía la posesión de la corona hispánica.
Effect of tungsten trioxide nanosheets prepared under low-energy state on wood surface modification
Authors: Sun Minglei , Song Kuiyan
Published: April 2023

Tungsten trioxide (WO3) nanosheets were deposited onto a wood surface by a solvothermal synthesis method using temperatures between 90 and 120 °C. These WO3 nanosheets were used to improve the color, as well as to enhance the photochromic characteristics and ultraviolet aging resistance of the wood. The results indicate that the WO3 nanosheets on the wood’s surface were affected by the treatment temperature. The formed nanosheets included nanoparticles and rod-shaped structures, which are highly crystallized. Different structures were generated in the nanosheets, which affected their functionality. The modified wood not only exhibited photochromic phenomena when excited by ultraviolet radiation, but also demonstrated resistance against ultraviolet light aging.
Organic and inorganic fillers’ role on the amelioration of Kappaphycus spp.-based biopolymer films’ performance
Authors: Hasan Muhammad , Lai Tze Kiat , Chong Eunice Wan Ni , Gopakumar Deepu A. , Rizal Samsul , Hossain Mohamad Sohrab , Fazita Mohammad Rawi Nurul , Haafiz Mohamad Kassi Mohamad , Paridah Mohamad Tahir , Abdul Khalil H. P. S.
Published: April 2023

The potential of organic and inorganic fillers at different loadings (ranging from 1% to 10%) was evaluated as a means to enhance the performance of Kappaphycus spp.-derived biopolymer films. The morphological properties of organic and inorganic fillers were characterized by scanning electron microscopy (SEM). The organic fillers displayed an irregular rod shape with sizes from 60 µm to 80 µm, while the inorganic fillers displayed spherical shapes with a much smaller size range (0.08 µm to 0.25 µm). The contact angle (CA) and mechanical properties of the fabricated biopolymer films were remarkably enhanced compared to the neat biopolymer films due to the incorporation of organic and inorganic fillers. The highest tensile strength (TS), CA, and water barrier properties were attained by biopolymer films that incorporated 5% organic and 1% inorganic fillers. Up to now, there has been no such report on the role of organic and inorganic fillers on tuning the performance of the Kappaphycus spp.-based biopolymer films. This work demonstrated that the biopolymer films containing inorganic fillers promoted better physical-mechanical performance compared to the biopolymer films with organic fillers, achieving desirable properties for various packaging applications.