bluuebunny/crossref_metadata_2025 huggingface dataset:
Prevalence of Pancytopenia/ Bicytopenia in Pediatric Population and its Association with Etiology Based on Bone Marrow Findings
Authors: Khalid Nida , Azhar Hajra , Afzal Javeria , Saqib Zeneara , Durrani Sundus , Irfan Muhammad
Published: June 2023

Background: An important clinico-haematological condition known as pancytopenia or bicytopenia is brought on by a multitude of disease processes that either directly or indirectly affect the bone marrow. Aim: To ascertain the prevalence of cytopenias in the pediatric population presenting to a tertiary care hospital in Rawalpindi and its correlation with age and gender distribution, clinical presentation, and aetiology. Study Design: Descriptive cross-sectional study. Methodology: It was a descriptive cross-sectional study carried out at Holy Family Hospital in Rawalpindi's hematology division. Using non-probability consecutive sampling, 253 individuals referred for bone marrow testing were included in the study, of which 108 patients had pancytopenia and 108 had bicytopenia. Data was gathered on the patient's mode of presentation, clinical examination, full blood counts, and bone marrow analysis. The data were analyzed using SPSS 22, and descriptive statistics were computed. Using chi-square test with a P value of 0.05 was taken as significant. Results: Bicytopenia was discovered in (133)52.6% of patients and pancytopenia in (120)47.4% of patients. 139 (55%) of the 253 instances involved men, while 114 (45%) were women. Fever 225 (89%), bleeding symptoms 52 (20.5%), and bruising 36 (14.2%) were the most frequent presenting complaints. The most frequent result on examination was pallor234, which was followed by hepatomegaly118 (46.64%) and splenomegaly114 (45.05%). In the total blood count, bicytopenia (133), 52.6%, and pancytopenia (120), 47.4%, were the most common findings. Practical Implication: There is scarcity of such data on paediatric patients, and to the best of our knowledge, no study has analysed the paediatric bicytopenic / pancytopenic patient in our centre. Thus present study was planned inorder to determine the prevalence of different etiology of bicytopenia /pancytopenia and its association with clinico-haematological parameters. Conclusion: It was discovered that bicytopenia/pancytopenia was frequently the reason for bone marrow testing. Three common underlying etiologies acute leukaemia, megaloblastic anemia, and aplastic anemia were discovered. Keywords: Cytopenias, Bone Marrow, Pediatric Population, Clinico-haematological Parameters and Prevalence.
Comparative Study on The Phytochemical, Antistaphylococcal and Antioxidant Properties of the Stem Bark of Jatropha curcas L and Jatropha gossypifolia L
Authors: Oyetayo Victor Olusegun , O.E Temenu, O.E
Published: June 2023

This study was conducted to assess the phytochemical, antistaphylococcal and antioxidant properties of the leaf and stem bark of Jatropha curcas and Jatropha gossypifolia. Ethanolic extract of the leaf and stem bark of Jatropha curcas and Jatropha gossypifolia was obtained using standard methods. Qualitative and quantitative phytochemical properties of theJatropha plant was assessed using standard methods. Antistaphylococcal and minimum inhibitory concentration of the extracts were assessed against Staphylococcal aureus obtained from different sources using agar diffusion method. Ferrous ion and hydroxyl radical scavenging activity of the extracts were also determined using standard methods. Quantitative phytochemical screening revealed that the distribution of phytochemicals in the two Jatropha species do not follow a regular trend. However, saponin was highest in Jatropha curcas stem bark (35.64 mg/g) while Jatropha gossypifolia stem bark and leaf have the highest flavonoid (31.35 mg/g) and alkaloids (23.20 mg/g) respectively. The antistaphylococcal effect of the combined extract was higher and significantly different (P≤0.05) than when used singly. The highest antistaphylococcal effect (19.83mm) was recorded for the combination of Jatropha curcas and Jatropha gossypifolia leaf (JCL and JGL) against Staphylococcus aureus obtained from blood. Antioxidant assay of extracts revealed a concentration dependent effect. The antioxidant activities of the extracts vary from one extract to the other. The results obtained from this study indicates that bioactive compounds present in Jatropha curcas and Jatropha gossypifolia can be exploited as source of effective antistaphylococcal and antioxidant compounds.
Geological Complications and Environmental Hazards of the Cement Raw Materials Quarry Sites in Yemen
Authors: Al-Anweh Ahmed M. , El-Anbaawy Mohammed Ibrahim , Abu-Zeid Mohamed Mahmmoud , Al-Akhaly Ibrahim
Published: June 2023

Extensive field and site investigations were conducted to assess and evaluate the situation in the presently exploited quarries of cement raw materials in Yemen. These quarries have several geological complications represented mainly by high elevations, steep slopes, rugged topography, heterogeneity in bed thickness, lithologic composition and quality, presence of igneous sills and dykes, intensive fracturing and jointing and abundance of karstification features. Moreover, the processes of quarrying and related operations have several negative environmental impacts the most important of which are soil failure, overburden and land sliding, toppling and rock falls (which result in considerable mass wasting) and emission of dust and noise. Generally, quarrying operations are more hazardous in quarries of gypsum and basement rocks than in those of carbonates and volcanics. Furthermore, the quarries have problems related to the conservation of natural resources. These are represented primarily by the excavation of the valuable agricultural and reclaimed lands and improper exploitation of the cement raw materials and the fresh and underground waters the reserves of which decreased drastically. To deal with the above-mentioned problems, a number of recommendations are outlined. They comprise mitigation measures which must be strictly implemented. Also, it is of almost importance to conduct prospecting for new occurrences of the presently exploited cement raw materials and their possible substitutes as well as additional groundwater resources.
AGENCY BANKING, MOBILE MONEY OPERATION AND BANK PERFORMANCE IN BENUE STATE, NIGERIA
Authors: Peter Ngbede AJAM
Published: June 2023

This study will examine agency banking, mobile money operation and bank performance in Benue State. Three proxies of agency banking namely; point of sale, mobile telephone banking and automated teller machine card usage were examined to see their effects on the performance of deposit money banks in the study area. The study adopted survey design and used structured questionnaire for data collection. The population and sample of the study consist 1,350 management staff and registered mobile money agents in the study area. A purposive sampling was used to select the elements to be used for the study. The instrument of data collection was subjected to content and construct validity while the reliability of the instrument was tested using Cronbach’s Alpha statistics. Descriptive statistics was used analyze descriptive data while multiple regression analysis was used to estimate the effect of the independent variables on the dependent variable of the study. The major finding from the study indicates that point of sales and mobile telephone banking have positive and significant effects on bank performance in the study area. It was recommended among others that deposit money banks need to improve in their operations to ensure a deeper penetration into the rural area. The study has contributed significantly to the ongoing debate of the role of agency banking on financial inclusion and bank performance in the study area.
Analysis of the scientific production on environmental crimes during the COVID-19 pandemic
Authors: Barbosa Samara Moreira , Billota Patrícia
Published: June 2023

The subject of environmental crime has become current at the national level and has been identified as an object of interest in different areas of knowledge and, therefore, different approaches are adopted in this regard. This work aims to map this production by means of bibliometric analysis. The selection of articles that constitute the corpus of the research was carried out through the Web of Science platform. We searched for scientific articles that had in their titles, abstracts or keywords the term: environmental crime with a filter for any language, without definition of locality and between the years 2018 and 2022, a period that is linked to the Covid-19 pandemic in the world. After the selection, the top 10 texts were listed.
Wooden building systems: imminent growth or exponential problem?
Authors: Almeida Amanda Ceinoti de , Silva Ricardo Dias , Moura Jorge Daniel de Melo
Published: June 2023

Industrialized building systems in engineered wood are increasingly used worldwide. Cross Laminated Timber – CLT is among the main constructive systems with wide use in some countries and mainly on the rise in Brazil. The high demand for the raw material for the production of engineered wood puts the debate on the development of the world forestry sector on the agenda. Currently, the most significant forest area is equivalent to native forests (93%), while planted forests occupy 7% of the global area. Given this, estimates found that reforestation wood production will not be enough to meet demand by 2050. Furthermore, deforestation may be intensified with this exponential problem.
Physics Textbooks: the elaboration of instruments for their evaluation and choice
Authors: Rodrigues Dilcelia Cristina Bruch , Garcia Nilson Marcos Dias
Published: June 2023

The selection and choice of textbooks represents an action of great teaching responsibility, because a careful and critical evaluation can enable better conditions for the work in the classroom. However, not always this activity occurs with the best conditions, because it is inserted in the already multiple and exhausting teaching actions. In order to contribute to Physics teachers in this task, this paper reports on an investigation that aimed to develop an instrument to guide the selection of Physics textbooks in a more friendly and accessible way. Taking as reference the official normative documents of Brazilian education, the results of research in Physics teaching, the Edital and Teacher's Guide of the National Textbook Program (PNLD) and relying on the proposal for evaluation of textbooks presented by Aran (1996), the instrument makes it possible to evaluate the text books in relation to textual and graphic-editorial aspects and questions related to interdisciplinarity, contextualisation, modelling, problem solving, experimentation, use of texts, information technologies, and evaluation of the content, simplifying and systematising the process for teachers.
Teacher training and evaluation processes in early childhood education: legal achievements, possibilities and challenges
Authors: Santana Brisiane Ribeiro Costa
Published: June 2023

This article sought to investigate the influence of the training of Brazilian teachers working in early childhood education classes, in the contours on which the processes of evaluation and pedagogical documentation are designed.  It is considered that the way teachers carry out assessments of children's development and learning, reveal their conceptions about childhood and are influenced by subjective questions related to their life experiences and values. Points relating to difficulties in teacher training, initial and continuing, are also discussed, linked to the construction of a professional identity aimed at meeting the specificities and singularities inherent to work in early childhood. This is a bibliographical research, referenced in the systematic review of scientific productions that deal with the themes: teacher training, evaluation of learning and development in early childhood education, based on the analysis of titles, keywords and abstracts in the Scielo database, published from 2018 to 2022.
Methodological trends in Physics textbooks
Authors: Rodrigues Dilcelia Cristina Bruch , Garcia Nilson Marcos Dias
Published: June 2023

Teaching and learning relationships are built on conceptions and understandings about education expressed by the subjects involved, even if this process is unknown to them. As one of the artifacts widely used by teachers in their teaching activities, the textbook, by containing characteristics of the thinking of their authors and the context of the period of publication, reflects these conceptions. Taking as a reference the studies of Libâneo (2005) regarding pedagogical trends, and those of Krasilchik (1987), on the characteristics of education present in certain historical periods, an investigation was carried out in order to identify and analyse the conceptions of education manifested in Physics textbooks. To make it possible to analyze the textbook regarding these aspects, an instrument was developed that can help the teacher in choosing the textbook that best suits his/her conceptions of education and teaching. The process of creating and using this instrument, as well as the results obtained, will be presented.
Infrared thermography as a complementary tool in dental
Authors: Figueredo Antonio , Azevedo Mauro , Da Silveira Paula , Lima Jhulie , Teixeira Kaylane , Alvarado Andrea , Brígido Isaac , Paiva Leyriane , Costa Marinna , Silva Raquel , Viana Mabel , Brígido Karla , Brígido Jandenilson
Published: June 2023

Infrared cameras have the ability to measure infrared radiation, resulting in the generation of thermal images where each pixel refers to a different temperature value. Thermographic images allow measuring the thermal variations that can be used to obtain physiological information. This study aimed to analyze the applications of thermography in dentistry through an integrative literature review. This work is the result of research carried out in the following databases: Virtual Health Library (VHL), PubMed, Ebsco and ScienceDirect. The following descriptors “thermography”, “dentistry” and “diagnosis were used, and 13 articles were selected to compose this work. This integrative review allowed analyzing, through several studies, the clinical applications of thermography in dentistry. Because it is a non-invasive method, this technique has a promising future in dentistry. Therefore, based on the studies already published and analyzed, it can be concluded that infrared thermography is an auxiliary tool in dental diagnosis and useful for monitoring and examining therapeutic interventions.
MONITORAMENTO E AVALIAÇÃO DOS PLANOS DE EDUCAÇÃO: DESAFIOS AOS CONSELHOS DE EDUCAÇÃO
Authors: Oliveira Patrícia Soraya C. B. de , Oliveira Ney Cristina Monteiro de , Damasceno Alberto
Published: June 2023

O artigo é produto de pesquisa de doutorado em andamento, traz reflexões sobre o planejamento educacional evidenciando o monitoramento e avaliação do Plano Nacional de Educação (PNE) como instrumentos constitutivos desse processo. O estudo tem como objetivo analisar os desafios para implementar o PNE como ferramenta de planejamento educacional no Brasil; examinar os conceitos de monitoramento e avaliação, abordando limites e possibilidades da atuação dos conselhos de educação nesse processo e apresentar os desafios atuais para recuperar um projeto educacional democrático. É uma pesquisa de enfoque qualitativo, do tipo documental. As principais bases teóricas são: Dourado (2010; 2013; 2016; 2017), Santos e Scaff (2021), Scaff e Ferreira (2019), Bordignon (2009; 2013; 2014) e outros. Definiu-se como corpus principal de análise o Plano Decenal de Educação para Todos de 1993, a Emenda Constitucional nº 59/2009, a Lei nº 10.172/2001 que aprovou o PNE 2001-2011 e a Lei nº 13.005/2014 que aprovou o PNE 2014-2024. Confirma-se que o atual processo de desmonte das políticas educacionais implementadas sobretudo a partir do ano de 2016 demarcou uma conjuntura adversa que atuou a partir dos princípios neoliberais e neoconservadores que comprometeu o atingimento das metas do PNE por se tratar de um projeto de sociedade que atende muito mais as ideias hegemônicas do capital. Enfatiza-se os desafios atuais para recuperar um projeto educacional democrático que garanta direitos e uma educação para todos.
Ảnh hưởng của hàm lượng DHA làm giàu luân trùng (Brachionus plicatils) và artemia (Artemia franciscana) lên tăng trưởng, biến thái và tỷ lệ sống của ấu trùng của cá khoang cổ cam (Amphiprion percula Lacepède, 1802)
Authors: Nguyễn Thị Thúy , Nguyễn Tấn Sỹ , Phạm Thị Khanh , Đặng Trung Thành , Trần Văn Dũng
Published: June 2023

DHA và các axít béo không no có vai trò quan trọng trong việc cải thiện kết quả ương ấu trùng cá biển nói chung. Trong nghiên cứu hiện tại, các hàm lượng DHA làm giàu thức ăn sống khác nhau (50, 100, 150 và 200 mg/L và đối chứng 0 mg/L) được thử nghiệm nhằm đánh giá ảnh hưởng lên tốc độ tăng trưởng, tỷ lệ sống và tỷ lệ biến thái của ấu trùng cá khoang cổ cam. Ấu trùng cá khoang cổ cam được ương trong các bể kính 30 lít với mật độ 1 con/ 1,5 lít nước. Ấu trùng được cho ăn thức ăn sống làm giàu DHA (A1 DHA Selco), gồm luân trùng (3 ngày đầu) và metanauplius Artemia (từ ngày thứ 2 trở đi). Thí nghiệm được thực hiện với 3 lần lặp trong thời gian 45 ngày. Kết quả nghiên cứu cho thấy việc bổ sung DHA làm giàu ở bất kỳ hàm lượng nào (50 – 200 mg/L) cũng cải thiện đáng kể tốc độ tăng trưởng, tỷ lệ sống và biến thái của ấu trùng cá khoang cổ cam so với đối chứng (P < 0,05). Trong đó, hàm lượng bổ sung 150 mg/L được xác định là tối ưu. Việc gia tăng hàm lượng lên mức 200 mg/L không những không cải thiện mà còn làm giảm kết quả ương so với mức 150 mg/L. Từ nghiên cứu này có thể kết luận rằng ấu trùng cá khoang cổ cam nên được cho ăn thức ăn làm giàu DHA (150 mg/L) nhằm đạt được các chỉ tiêu tăng trưởng, tỷ lệ sống và biến thái tối ưu.
Ảnh hưởng của hàm lượng chất màu chiết xuất từ củ dền (Beta vulgaris) bổ sung vào thức ăn lên sinh trưởng và màu sắc của cá khoang cổ nemo (Amphiprion ocellaris Cuvier, 1830)
Authors: Trần Thị Lê Trang , Đặng Trung Thành , Trần Văn Dũng
Published: June 2023

Thí nghiệm một nhân tố được thiết kế theo kiểu ngẫu nhiên hoàn toàn trong thời gian 75 ngày nhằm đánh giá ảnh hưởng của hàm lượng chất màu, chiết xuất từ củ dền, bổ sung vào thức ăn lên kết quả nuôi cá khoang cổ nemo. Cá giống cỡ 0,81 ± 0,07 g và 3,47 ± 0,05 cm được bố trí vào hệ thống bể lọc sinh học tuần hoàn (65 lít/bể) với mật độ 15 con/bể. Các chỉ tiêu sinh trưởng, tỷ lệ sống, hiệu quả sử dụng thức ăn và màu sắc của cá được đánh giá vào thời điểm kết thúc thí nghiệm. Kết quả nghiên cứu cho thấy việc bổ sung chất màu từ củ dền vào thức ăn đã cải thiện các chỉ tiêu tăng trưởng của cá. Chiều dài và khối lượng của cá ở nghiệm thức bổ sung 350 mg/kg (4,13 ± 0,02 cm; 1,37 ± 0,02 g) cao hơn so với đối chứng (4,04 ± 0,02 cm; 1,28 ± 0,01; P < 0,05). Hiệu quả sử dụng thức ăn ở các mức bổ sung 150 – 450 mg/kg thức ăn cao hơn so với đối chứng (62,6 – 65,1% so với 55,9%; P < 0,05). Hàm lượng bổ sung từ 350 – 450 mg/kg thức ăn cũng cải thiện đáng kể màu sắc da cá (chỉ số a*, 9,50 – 10,48) và hàm lượng carotenoids tích lũy (28,14 – 30,60 μg/g da) so với các nghiệm thức còn lại (P < 0,05). Tuy nhiên, việc bổ sung chất màu từ củ dền vào thức ăn không ảnh hưởng đến hệ số điều kiện (K) và tỷ lệ sống (SR) của cá (P > 0,05). Nghiên cứu cho thấy tiềm năng của việc ứng dụng nguồn chất màu tự nhiên từ củ dền trong việc cải thiện kết quả nuôi cá cảnh biển; và hàm lượng 350 mg/kg thức ăn được khuyến cáo là phù hợp với cá khoang cổ nemo.
Một số đặc điểm sinh trưởng và sinh sản của nhum sọ Tripneustes Gratilla (Linnaeus, 1758) ở vùng biển Lý Sơn, Tỉnh Quảng Ngãi
Authors: Nguyễn Phi Uy Vũ , Trần Công Thịnh , Lê Thị Thu Thảo , Phạm Văn Tuấn , Bùi Đức Lỉnh
Published: June 2023

Nghiên cứu về các đặc điểm sinh trưởng, sinh sản làm cơ sở cho các giải pháp sử dụng hợp lý và phát triển nguồn lợi Nhum sọ Tripneustes gratilla (Linnaeus, 1758) ở vùng biển Lý Sơn, tỉnh Quảng Ngãi được thực hiện. Mẫu được thu định kỳ hàng tháng từ tháng 08/2019 đến tháng 07/2020. Kết quả nghiên cứu cho thấy đường kính vỏ (L) dao động từ 29,30 - 102,28 mm, trung bình 65,30 ± 15,75 mm; chiều cao vỏ (H) 20,00 -58,38mm, trung bình 39,22 ± 28,72mm; khối lượng toàn thân (W) 15,61 - 254,60g, trung bình 73,40 ± 47,53g. Sự tương quan về kích thước (đường kính vỏ và chiều cao vỏ) với khối lượng toàn thân của Nhum sọ được thể hiện qua công thức W = 0,003L2,3845 với hệ số tương quan là R2 = 0,78 và W = 0,0056H2,545 với hệ số tương quan là R2 = 0,75. Tỉ lệ đực cái của Nhum sọ được xác định là 1,00:1,38. Nhum sọ sinh sản quanh năm, mùa vụ chính từ tháng 8 đến tháng 4 năm sau (hệ số thành thục sinh dục GSI trung bình tháng dao động 5,49-10,63), đỉnh điểm vào tháng 1/2020 với GSI = 10,63 ± 2,73. Nhum sọ thành thục sinh dục lần đầu ở kích thước đường kính vỏ là 63,39 mm, với sức sinh sản tuyệt đối 38,13 × 106 ± 1,96 × 106 trứng. Kết quả nghiên cứu là cơ sở khoa học cho các giải pháp pháp sử dụng hợp lý và phát triển nguồn lợi Nhum Sọ ở vùng biển này.
Mid- to long-term success rate and functional outcomes of acromioclavicular injections in patients with acromioclavicular osteoarthritis
Authors: Miedema N. , Sierevelt I.N. , Alta T. D. W. , Vossen R.J.M. , van Noort A.
Published: June 2023

Background: Acromioclavicular (AC) osteoarthritis (OA) is a frequent pathology of the shoulder in elderly patients. Drug injection plays an important role in treatment of AC OA. Literature has demonstrated excellent short-term results regarding shoulder function and pain. However, mid- to long-term results are lacking. The aim of this study was to assess the efficacy of a single intra-articular AC injection in patients with AC OA and to identify predictive factors for success.Methods: A retrospective study was performed to analyze success rate, shoulder function, and pain perception after a single intra-articular injection in patients with AC OA. Success was defined as the absence of reinterventions such as additional injection or surgery. Outcome measures were 1-year success rate and clinical outcome scores of Numeric Rating Scale (NRS) for pain, Oxford Shoulder Score, and Subjective Shoulder Value.Results: Ninety-five patients participated in this study. At a median final follow-up of 0.8 years (interquartile range, 0–6), 57 of these patients (58%) had undergone a reintervention. The 1-year success rate was 47% (95% confidence interval, 37%–57%), with NRS at rest as the sole factor significantly associated with success. Thirty patients not requiring reintervention reported significant improvement from baseline for all reported outcome measures at final follow-up.Conclusions: AC injections offer a 1-year success rate of 47%. The AC injection produces good mid- to long-term clinical outcomes regarding shoulder function, quality of life, and pain perception in one-third of patients. Further research is essential to analyze mid- to long-term outcomes of AC injections.
ANALISIS STRUKTUR DAN KONSEP TEOLOGIS YANG TERMUAT DALAM LONTAR TUTUR GONG BESI
Authors: Swana I Putu , Dewi Ni Luh Made Larasanti Komala
Published: June 2023

Penelitian ini bertujuan untuk menganalisis struktur dan konsep teologis yang termuat pada Lontar Tutur Gong Besi, untuk dapat dijadikan suatu pengetahuan bagi pelajar, mahasiswa dan masyarakat umum pada bidang susastra Hindu. Kajian dalam penelitian ini menggunakan kualitatif deskriptif dengan pendekatan studi pustaka dengan Teknik analisis data pada dokumen yang relevan utamanya analisis pada dokumen Lontar Tutur Gong Besi. Berdasarkan hasil intepretasi atas Lontar Tutur Gong Besi, maka dapat dijelaskan bahwa struktur dalam Lontar Tutur Gong Besi ini terdiri dari struktur formal dan struktur isi. Struktur formal meliputi   penggunaan bahasa kawi bali dengan gaya bahasa antitesa, asosiasi, repetisi, dan antonomasia. Sedangkan struktur isi meliputi alur cerita dari bagian awal, inti dan penutup. Kosep teologis yang termuat dalam Lontar Tutur Gong Besi ini meliputi, Henotheisme, Animisme, dan Monotheisme. Lontar Tutur Gong Besi bersifat Siwaistik. Lontar ini termasuk dalam kelompok Lontar Tattwa Agama, pembahasan utama pada lontar ini berkaitan dengan kemahakuasaan Bhatara Dalem. Masyarakat yang ber agama Hindu di Bali memepercayai bahwa Bhatara Dalem merupakan manifestasi dari Dewa Siwa.
MODERASI BERAGAMA SOLUSI HIDUP RUKUN DI INDONESIA
Authors: Wiguna Ida Bagus Alit Arta , Andari Ida Ayu Made Yuni
Published: June 2023

This research aims to find out the definition and concept of religious moderation, factors that influence religious moderation, the impact of religious moderation, efforts to promote religious moderation and shortcomings and obstacles in implementing religious moderation. This research uses a literature review with qualitative analysis using a critical analysis model. The results of this study are Encouraging interfaith dialogue, Improving multicultural education, encouraging interfaith cooperation, encouraging religious leaders to play an active role in promoting the values of religious moderation and building interfaith cooperation and increasing individual awareness.
Significations Embodied in the Co-Construction of Child Rearing Practices: Outline of a Frame for its Analysis
Authors: Pérez-Campos Gilberto
Published: June 2023

In this short communication, the sketch of a proposal for the analysis of how children come to embody cultural significations in the process of being actively involved with their caretakers in the instantiation of episodes of social practices that constitute their everyday life, is presented. This process takes place at the action level, which involves interactions that are enacted rather than reflected, and constituted mainly through the way caretakers achieve the involvement of infants as participants in such practices, through their reflexive monitoring of action. Only later, when people start acting at the semiotic level and the meta-reflexive level, they can position themselves vis-à-vis the significations they embody in a tacit or conscious way.
Is Detecting Discontinuity Difficult? Evidence from the Visual Trend Classification of Scatterplots
Authors: Blech Christine , Reimann Daniel , Ram Nilam , Gaschler Robert
Published: June 2023

Visualization of data comes with the promise that even unexpected aspects of the data can be detected. For instance, viewers might discover that patterns in a scatterplot follow a non-linear trend. Using two experiments, we examined whether and when scatterplots depicting different types of mathematical functions are classified correctly and confidently. In Experiment 1, 237 participants categorized scatterplots that depicted more or less noisy linear, negative exponential, or discontinuous step functions. Results indicated a classification advantage for the continuous linear and negative exponential functions over the discontinuous step function. Generalizing from these findings, in Experiment 2, 231 participants categorized scatterplots that depicted more or less noisy versions of a broader range of functions, including rising continuous linear, quadratic (half parabola), and discontinuous linear (kinked) functions and rising and falling continuous quadratic (full parabola), sine wave, and discontinuous linear (inverted-v) functions. Generally, results suggested that scatterplots based on discontinuous functions are difficult to classify. Overall, the results indicated a classification advantage for the continuous functions over the discontinuous functions and underscore the need for scientists and practitioners to be extremely careful when developing theory and making decisions based on exploration of raw data visualizations.
Is There a Bidirectional Relationship Between Appearance-Based Rejection Sensitivity and Materialism in Early Adults?
Authors: Chen Yunxiang , Liu Xiangping
Published: June 2023

Appearance-based rejection sensitivity (A-RS) is closely related to materialism. However, there is no research focusing on the bidirectional relationship between them. With the tracking data at 2 points of time, this study investigated whether this bidirectional relationship exists longitudinally, within which potential mediation (appearance-based social comparison) and moderation (appearance-contingent self-worth, A-CSW) mechanisms were also examined. Data in 2 samples of college students (Sample 1 with cross-sectional data, N = 875; Sample 2 with tracking data, N = 130) were collected. Results indicated a bidirectional relation between A-RS and materialism at the same point in time. Time 1 A-RS showed a marginally significant association with Time 2 materialism. As for the underlying mechanism and individual difference, cross-sectionally, the appearance-based social comparison was found to partially mediate the contribution of A-RS to materialism; this mediation also worked in the contribution of materialism to A-RS. Longitudinally, appearance-based social comparison had a mediation role only in the relation of Time 1 A-RS and Time 2 materialism. Specifically, A-CSW showed a moderation role in this positive relation, which happens only in those who base self-worth on appearance. Practical implications, limitations, and future directions of this study are discussed.
Treatment Theories of Cervical Radiculopathy with Traditional Chinese Medicine
Authors: Qin Jiahui , Wang Xintong , Yang Shu , Li Kaiping
Published: June 2023

Cervical radiculopathy (CR) is a common disease of cervical spine, which is mainly caused by neurodegeneration, middle-aged and old people, and is senility disease. The main clinical manifestations were stiff neck and shoulder pain, limitation of movement, upper limb soreness, radiation pain, numbness and abnormal sensation. This article summarizes the treatment of cervical radiculopathy with traditional Chinese medicine and western medicine by exploring the etiology and main clinical analysis index of nerve root disease.
PROTAC Pharmaceutical Research and its Applications
Authors: Xu Yixin
Published: June 2023

At present, there are very few protein targets that can be used as drugs, with approximately 15% of proteins being regulated by small molecules and biomacromolecules, while 85% of proteins currently do not have drug targets and cannot be regulated by small molecules and biomacromolecules. Proteolytic targeting chimeras (protacs) can degrade many non-pharmacological target proteins through proteasomes, thereby regulating their regulatory effects. Protein degradation targeting chimeras is an emerging direction in drug research and development. Traditional inhibitors have a blocking effect, leading to drug resistance and off target phenomena. However, this technology degrades the target protein through a 26S protease system. Structurally, PROTAC consists of three parts: the left end is a ligand that binds to the target protein, the right end is a ligand that connects to ubiquitin ligase, and the middle is connected through a "Linker". In the patient's body, one end of PROTAC is connected to E3 ubiquitin ligase, and the other end is connected to the target protein to be degraded. Through multiple rounds of ubiquitination, a ubiquitin chain is formed, achieving the UPS system to degrade the target protein. PROTAC small molecules have great prospects in the treatment of diseases. Unlike traditional small molecule drugs, they do not destroy the function of proteins, but completely degrade them. And PROTAC can be recycled, and the proteins of interest are polyubiquitinated and degraded through proteasomes. The dissociated PROTAC can also initiate new degradation, which is an important breakthrough in the fight against cancer cells. For example, we can design a PROTAC to hijack the protein required for unlimited proliferation of cancer cells, so that it can be degraded and inhibit the growth of cancer cells. Further exploration is needed for the development and clinical application of PROTAC drugs.
Low-cost Fermentation of Polyhydroxyfatty Acid Esters
Authors: Zhen Xin , Li Chungeng
Published: June 2023

With the depletion of traditional fossil energy and environmental problems, there is an urgent need for alternative materials. Biosynthesis not only achieves low-carbon green economy, but also reduces energy consumption. Polyhydroxyfatty acid ester is a kind of material with excellent performance, but the production cost is high, mainly due to the high cost of fermentation carbon source, fermentation process and other factors. Using waste as substrate not only reduces fermentation costs but also solves environmental problems. On the other hand, mixed strains can be used simultaneously to reduce the cost of fermentation.
Analogia e univocità: una convivenza possibile? Il caso Petrus Thomae
Authors: Marrone Francesco
Published: June 2023

La storia medievale della teologia e della metafisica è attraversata da una rilevante discussione a proposito della predicazione della nozione di ente. I modelli più spesso evocati a tal fine sono stati, com’è noto, l’analogia e l’univocità. Rispetto a questa alternativa, la tendenza generale degli interpreti è stata quella di intendere l’univocità e l’analogia come regimi predicativi opposti o contraddittori. Questa tesi ha dato vita a una sorta di opinione comune e diffusamente condivisa. La verità di questa tesi, tuttavia, non si è mai imposta in maniera definitiva: il primo dibattito sulla compatibilità dell’univocità e dell’analogia risale proprio al Medioevo. A tal proposito appare decisivo il contributo di Pietro di Tommaso (Pere Tomàs, Pietro Tomàs, Petrus Thomae): la settima delle sue Quaestiones de ente (ca. 1325) chiede infatti Utrum vera analogia et vera univocatio possint se compati in eodem conceptu. Il presente contributo cerca di riscostruire gli snodi principali dell’argomentazione che Pietro di Tommaso elabora in questo testo con la duplice finalità di valorizzare il contributo di questo autore nel quadro del dibattito teologico medievale e di giustificare l’opportunità delle ricerche che tentano oggi di ripensare il rapporto tra l’univocità e l’analogia nel pensiero scotista.
 
The history of medieval theology and metaphysics is marked by a relevant discussion about the predication of being. The semantic devices most frequently referred to in this regard were, as is well known, analogy and univocity. With respect to this alternative, the general tendency of scholars has been to understand univocity and analogy as opposite and contradictory modes of predication. This view has led to a kind of common and widely shared opinion. This thesis, however, has never prevailed conclusively: a debate on whether univocity and analogy were compatible dates back to the Middle Ages. In this respect, the contribution of Petrus Thomae is decisive: the seventh of his Quaestiones de ente (ca. 1325) asks in fact Utrum vera analogia et vera univocatio possint se compati in eodem conceptu. This contribution tries to reconstruct the main points of Petrus Thomae’s argumentation with the twofold purpose of enhancing the contribution of this author in the framework of the medieval theological debate and of justifying the opportunity of the current research that tries to rethink the relationship between univocity and analogy in the context of Duns Scotus’ thought.
Uno su mille. Contrappunto sulla predestinazione in Agostino
Authors: Parodi Massimo
Published: June 2023

Una riflessione, talvolta discutibile, su un problema centrale nello studio della storia, sul modo cioè di comprendere la sensibilità di uomini del passato, cercando di accostarla alla sensibilità di uomini nostri contemporanei. Si considera, come caso esemplare e particolarmente difficile, la riflessione di Agostino sul tema della grazia e della predestinazione. Ogni trasposizione di dottrine anche lungo la linea del tempo storico è certamente un tradimento delle intenzioni originali dell’autore, ma un tradimento necessario per sperare di capirlo. L’intreccio di tesi su predestinazione, grazia, destino e carattere può aiutare, ma solo a condizione di essere consapevoli che si tratta comunque di analogie che mai riescono a chiarire completamente, ma possono aiutare.
 
A reflection, sometimes questionable, on a central problem in the study of history, that is, on how to understand the sensibility of men of the past, trying to approach it to the sensibility of our contemporary men. We investigate, as an exemplary and particularly difficult case, Augustine's reflection on the subject of grace and predestination. Any transposition of doctrines even along the historical timeline is certainly a betrayal of the author's original intentions, but a necessary betrayal to hope to understand him. The interweaving of theses on predestination, grace, destiny, and character can help, but only on the condition of being aware that these are nevertheless analogies that never succeed in fully clarifying, but can help.
’Ho qui trovato un nuovo modo di dipingere’: pittrici finlandesi nel centro Italia fra Ottocento e Novecent
Authors: Amedei Michele
Published: May 2023

L’articolo indaga il soggiorno nel centro Italia di un gruppo di influenti pittrici finlandesi fra Ottocento e Novecento. Residenti a Firenze in momenti diversi della loro vita, le artiste esplorarono zone dell’entroterra e della costa toscana fuori delle più tradizionali mete turistiche, nel momento in cui in Finlandia andava maturandosi un rinnovato interesse per l’Italia, per la sua cultura e soprattutto per le antiche tradizioni pittoriche medievali e rinascimentali. Il soggiorno di quelle donne in Italia fu dunque segnato dallo studio dell’arte del passato, dall’esercizio della copia, dall’esplorazione delle campagne toscane, reinterpretate attraverso un registro che preferisce al più consolidato stile “pittoresco” lo sperimentalismo linguistico dedotto dal confronto con l’arte locale ma anche francese e tedesca contemporanea. I risultati sono dipinti e disegni, conservati nella maggior parte dei casi presso i principali siti museali finlandesi, eseguiti nel solco di quella sensibilità vitalistica nordica alla base della quale è l’adorazione della bellezza mediterranea nonché la fiducia nel ritorno della Classicità nella civiltà Occidentale.
USING CASE BASED LEARNING TO FOSTER CRITICAL LEARNING IN MEDICAL BIOCHEMISTRY
Authors: MALIK FA , FAROOQ B , KHAN MA , QURESHI ZH , AYUB MT , SAHU EH , BUKHARI HSMS , RAZA T
Published: June 2023

The interventional study was conducted in the Department of Biochemistry, Nishtar Medical Hospital, from January 2021 to January 2022 to analyze the impact of case-based learning on first-year biochemistry students' critical thinking skills and creative abilities. The study was conducted on 1st year MBBS students who had undergone CBL. A total of 60 students were included in the study. Study participants were randomly divided into a study group (n=30) and a control group (n=30). Pre-test questionnaires were administered to both groups; the control group was then seated in a separate room, and the study group was randomly subdivided into subgroups I, II, and III. Sub-groups were asked to design study cases on given topics and discuss the designed case with each other. The control group was asked to study the same topics individually. All participants then underwent a post-test. Responses were recorded. Results showed that the pre-test score (out of 20) in the study group ranged from 8.5-16.5 and in the control group from 9-17, which means that there was no significant difference between both groups before intervention (P>0.05). Post-test scores in the control group ranged from 8-17 and in the study group from 12-19, and this difference between the scores was statistically significant. Results showed that case-based learning increases students' critical thinking skills and enables them to consider alternatives, imagine possibilities, and seek solutions.
GERMPLASM POTENTIAL FOR DIFFERENT ADVANCE LINES OF GOSSYPIUM HIRSUTUM FOR WITHIN BOLL YIELD COMPONENTS
Authors: SHAFIQUE MT , BANO M , KHALID MN , RAZA A , SHAHID M , HUSSNAIN H , IQBAL M , HUSSAIN M , ABBAS Q , IQBAL MM , AHMAD HR , AQEEL M
Published: June 2023

Cotton production per hectare is low in Pakistan due to many biotic and abiotic factors.  As boll is the basic determinant for yield in cotton crop, a study on within boll yield parameters was carried out using 24 cotton bulk and 2 check varieties to check their variability for within boll yield components.  The experiment was performed in the research area of ​​the Department of Plant Breeding and Genetics, University of Agriculture, Faisalabad.  The genotypes were seeded in two replications following a randomized complete block design. Data were subjected to analysis of variance to check significance among different genotypes. Genotypes were significantly different. The genotype PB-132 performed best for most parameters including GOT, lint index, lint mass per seed, and seed density. Correlation analysis was applied to find out the association of these parameters.  Seed cotton yield was positively associated with the GOT, boll weight and number of seeds per boll while it negatively correlated with fiber fineness, seed volume, and seed surface area. The first principal component showed 26.37%, the second component showed 17.93%, the third component showed 14.88%, and the fourth component showed 14.40% of total variation. PCA analysis showed the genetic diversity among cotton genotypes. The current study's findings revealed the potential of different bulks of cotton for developing high-yielding varieties. This information may be used to develop breeding strategies to enhance cotton production and variety.
Urban-tribal vegetation: A concept based on regional development
Authors: Meher-Homji V.
Published: June 2023

After reviewing general definitions of flora, vegetation, forest and systems of classification, the author suggests viewing vegetation according to the degree of development of a region and consequent density of human population. Four classes may be recognised-viz. urban, suburban, rural and tribal. Urban categories would be limited to gardens, parks and avenue trees. Suburban would include ruderal communities. Rural group would relate to croplands, weeds and wastelands. The tribal territory would comprise the habitats of Wildlife viz. Forests and Savannas. With vanishing Wildlife, the latter category is experiencing man-animal conflicts. The crux of the problem is to keep the poachers at bay, providing welfare schemes for the tribals. Problems raised by urban expansion into forest and mangroves have been pointed out.
Bipolar Neutrosophic Finite Switchboard State Machines
Authors: Iampan Aiyared ,   Fuzzy Algebras and Decision-Making Problems Research Unit, Department of Mathematics, School of Science, University of Phayao, Mae Ka, Mueang, Phayao 56000, Thailand,   Department of Basic Sciences and Humanities, Dhanekula Institute of Engineering and Technology, Ganguru, AP, India,   Department of Engineering Mathematics, College of Engineering, Koneru Lakshmaiah Education Foundation, Vaddeswaram, AP, India,   Department of Engineering Mathematics, College of Engineering, Koneru Lakshmaiah Education Foundation, Vaddeswaram, AP, India, Kalyani U. Venkata , Eswarlal T. , Reddy G. V. R.
Published: May 2023

The notion of bipolar neutrosophic finite switchboard state machines (BNFSSTMs), homomorphisms and strong homomorphisms of bipolar neutrosophic finite state machines (BNFSSTMs) are introduced and some related results are studied.
Similarities and differences between familial Mediterranean fever (FMF) and multisystem inflammatory syndrome (MIS-C) in children
Authors: Yoldaş Meyri Arzu , Çelebi Tayfur Aslı , Hancı Fatma , Danış Ayşegül , Bolu Semih , Atasoy Halil İbrahim
Published: June 2023

Aim: We aimed to reveal the similarities and differences between the rare and severe multisystem inflammatory syndrome (MIS-C) and active familial Mediterranean fever (FMF) disease in children. Our study may help in the early recognition of MIS-C syndrome in children and distinguish it from other diseases with similar symptoms.Methods: We evaluated the demographic and clinical characteristics, laboratory findings, treatments and outcomes of patients with MIS-C syndrome and active FMF.Results: The clinical and laboratory findings of a total of 66 patients hospitalized in our pediatric clinic with the diagnosis of active FMF (n: 42) and MIS-C syndrome (n: 24) were reviewed retrospectively. The reason for pediatric emergency admission was determined as resistant fever in all patients. When the clinical findings of the patients were compared, it was determined that joint and abdominal pain in the FMF group and vomiting, rash, cough, Lenfadenopati (LAP) and myalgia findings in the MIS-C group were statistically significantly higher (p
Evaluation of the relationship of balance and posture with speech functions in stroke patients
Authors: Arslan Mine , Kurul Ramazan
Published: June 2023

Aim: Balance disorders, postural dysfunctions, and speech disorders are common after stroke. This study aims to investigate whether there is a connection between language and speech function and posture and balance in paralyzed patients and to which speech area function the connection is related.Methods: Eighteen stroke patients with speech impairment and no cognitive impairment were included in the study. Balance and postures of stroke patients were evaluated using the Berg Balance Test (BBT) and Postural Assessment Scale for Stroke Patients (PASS-T), while their quality of life was evaluated using the Stroke and Aphasia Quality of Life-39 Test (SAQOL-39). Patients’ speech functions were evaluated using the Gülhane Aphasia Test-2 (GAT-2), voice-related assessments were made with the Voice-Related Quality of Life Scale (V-RQOL), and objective voice analysis.Results: The mean age of the participants was 59.10±14.72 years, the mean score of the Mini-Mental Test was 26.16±2.00. According to statistical analysis, there was a significant relationship between BBT score and GAT-2 (r: 0.552, p=0.017), and BBT score and SAQOL-39 mean score (r: 0.589, p=0.010), there was no significant relationship between BBT and V-RQOL (r: -0.075, p=0.768). While there was a significant relationship between PASS-T (r: 0.499, p=0.035) and SAQOL-39, no significant relationship was found with GAT-2 (r: 0.388, p=0.112). In addition, a significant correlation was found between the SAQOL-39 mean score and the GAT-2 total score (r: 0,606, p=0.008).Conclusion: It was observed that there is a significant relationship between balance functions and speech function and quality of life, and patients with good balance have better functional independence and speech functions. However, it was found that posture did not change speech function. Due to the importance of evaluation in treatment, it is thought that the evaluation of stroke patients who will receive speech and language therapy in terms of balance and postural functions will contribute to the speech functions of patients.