bluuebunny/crossref_metadata_2025 huggingface dataset:
The role of alkaline phosphatase (alp) and γ-glutamyltransferase (ggt) enzymes activities in monitoring the effect of enzyme replacement therapy in children with gaucher disease
Authors: Yasir SJ. Alrubaye  , Mohammed BM. Al-Juboori  , Haidar A. Abdulamir
Published: April 2020

To assess the role of γ-Glutamyltransferase (GGT) and alkaline phosphatase (ALP) in the diagnosis of Gaucher disease (GD) and monitoring the response of liver and bone to the treatment with enzyme replacement therapy (ERT).A case-control study was done on 67 children age range from 3-10 years who had Gaucher disease recruited from the Pediatric Department and Unit of rare disease at Al Imamain Al-Kathemeaain medical city,Gastroenterology and Hepatology Teaching Hospital, Children Welfare Hospital Consultation Clinic and Central Child’s Teaching Hospital. The activity of Alkaline Phosphatase (ALP) and γ- GlutamylTransferase (GGT) enzymes were measured in the samples of 67 Gaucher patients who were categorized as newly diagnosed untreated patients (n=9), patients receiving ERT for 3-5 months (n=18) 6-12 months (n=20) and patients receiving ERT for more than one year (n=20) and compared with twenty age-matched control subjects. The data indicated that the levels of both ALP and GGT in GD patients (216.82 ± 64.51, 35.94 ± 7.11; respectively) were significantly higher than those of controls (163.17 ± 49.34, 28.33 ± 3.36; respectively). Levels of ALP showed to return to levels comparable to those of controls after more than one year of treatment, while GGT levels become comparable to controls’ levels within 6-12 months. Negative significant (p<0.05) correlations were obtained between the levels of ALP and GGT activities with the duration of receiving ERT. Receiver Operating Characteristic (ROC) curve results revealed that GGTshowed a higher area under the curve (AUC), sensitivity, and specificity than ALP activities in all studied groups and subgroups.The possibility of using ALP and GGT as supportive diagnostic markers and as powerful markers for the monitoring of the liver and bone improvement with the administration of ERT.
A comprehensive review on application of stem cells for kidney diseases
Authors: Chetan Kumar V H  , Famna Roohi N K  , Gowda D V
Published: April 2020

The recognition of kidney failure as a complex disease requires multifactorial therapy in order to correct the conventional nonfactorial deficiency. Firstly, self-renewal means the ability of most organisms to reproduce without separation or aging; secondly, more than one form of a mature somatic cell is identified by each of the three regardless of kidney disorders, it can lead to loss of the environment, often bacterial infections. The reconstruction of the kidney has produced a spectacular response in this framework. The restoration of weakened and new kidneys is an alternative to renal replacement therapy. Both teratomas and embryoid bodies consist of three different layers of embryonic germs. Induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs) are present. These either provide useful therapeutical resources or can explore pathophysiology, including kidney diseases or infection. The benefit of ESCs is that they are relatively quick to receive and no longer subject to licensing/realty fees. Nevertheless, there are still some major concerns, such as ethical issues, the high risks to degeneration of neoplasm and immunocompatibility. The great benefit of iPSCs is that they have the same genetic history they drive making them an excellent method for studying the impact of genetic variants on disease path the key risk associated with the use of iPSCs are oogenesis, Tumorigenicity, and immunogenicity, the presence of an epigenetic memory, technical and economic issue associatedwith their long turnaround time and the presence of loyalties are the key risks associated with the use of iPSCs. Human pluripotent SCs have two major areas of use in kidney regeneration: they can be used by way organoid, scaffold,organ-on-a-chip, or blastocyst experiment to develop a "new kidney" or part of it. Renal progenitor cells are an alternative to either test or modulate regeneration of the kidney, offering significant benefits in the field. For encouraging us to hypothesize their medical use, a deeper understanding of the biology of pluripotent SCs is necessary.
Phytochemical Analysis and In-vitro Antioxidant Activity of Aerial Parts of Trichodesma indicum
Authors: Hamsalakshmi  , Joghee Suresh , M Akassh
Published: April 2020

This study was conducted to assess the physicochemical analysis, qualitative and quantitative phytochemical analysis and antioxidant activity of various solvent (n-hexane, ethyl acetate, ethanol, and water) extract obtained from Trichodesma indicum aerial parts. The physicochemical analysis was carried out using standard reported methods. Successive solvent extraction was carried out using n-hexane, ethyl acetate, and ethanol by the Soxhlet method, followed by maceration with water. Qualitative phytochemical screening was done using standard procedures. The extracts were analyzed for its total phenolic and total flavonoid contents by Folin - ciocalteu and Aluminium chloride colorimetric methods. For the extracts, antioxidant activity was screened using three different methods, 1, 1-diphenyl-2-picryl-hydrazyl assay, Nitricoxide assay, and Superoxide dismutase assay. Ascorbic acid has been used for antioxidant activity as a positive control. The percentage of inhibition was measured at various levels of concentration. The total ash, water-soluble ash, acid insoluble ash, sulfated ash, and the moisture content of the powdered drug was found to be 15.30, 07.50, 03.99, 21.00, 05.00%w/w. The qualitative phytochemicals found in the extracts are carbohydrates, proteins, and amino acids, flavonoids, phenols, phytosterols, saponins, tannins, and glycosides. The total phenolic and total flavonoid content of the extracts was found in the sequence of ethyl acetate > n-hexane > ethanol > aqueous. All the extracts demonstrated significant concentration-dependent antioxidant activity in DPPH assay, Nitric oxide assay, and Superoxide dismutase assay. The findings indicated that all solvent extracts of Trichodesma indicum have promising antioxidant activity and that could be the presence of phytochemicals present in the extract.
Gymnemic acid, a potent antidiabetic agent protects skeletal muscle from hyperglycemia mediated oxidative stress and apoptotic events in High fat and High fructose diet fed adult rats
Authors: Porkodi Karthikeyan  , Lakshmi Narasimhan Chakrapani  , Thangarajeswari Mohan  , Bhavani Tamilarasan  , Pughazhendi Kannan  , Kalaiselvi Periandavan
Published: April 2020

Type 2 diabetes is delineated by impaired metabolic flexibility, and intramyocellular lipid accumulation, causing insulin resistance, particularly in skeletal muscle by reducing insulin-stimulated glucose uptake. High-fat diet and high fructose (HFD and HF) administration in rodents bestows a model for hyperlipidemia, insulin resistance, and Type 2 diabetes. The current study is focused on elucidating the role of Gymnemic acid in combating hyperglycemia mediated oxidative stress and apoptotic events in the skeletal muscle of HFD and HF induced Type 2 diabetes in Wistar albino rats by boosting antioxidant defense system. Gymnemic acid, a saponin of triterpene glycoside contained in leaves of Gymnema Sylvestre, has potent anti-diabetic properties. Treatment with Gymnemic acid restored the antioxidant status (Gpx, SOD, CAT, GR, Vit C & Vit E) with significant (p<0.05) decrease in free radical levels and reinvigorated the expression of apoptotic and antiapoptotic proteins in Type 2 diabetic rats. Histopathological data demonstrate that oral administration of Gymnemic acid protects skeletal muscle fibers from an oxidative niche in HFD and HF in Type 2 diabetic rats. In accordance with this, Gymnemic acid might be regarded as a promising therapeutic agent against Type 2 diabetes, thereby restoring skeletal muscle integrity and function.
A Comparative Study on Relative Safety and Efficacy of Chlorpromazine and Risperidone in Schizophrenia patients
Authors: Kala Bahadur Rawal  , Sharad Chand  , Min Bahadur Luhar  , Sreekath B  , Muralidhar Reddy N  , Shivaraj B  , Vijaya Raj  , Nisi Grace Kuriakose
Published: April 2020

Patient safety is the foremost concern in the healthcare system. However, only a few studies have been conducted regarding the safety and efficacy of antischizophrenic drugs in the south Indian population. The main objective is to study relative safety profile and efficacy between Chlorpromazine and Risperidone among Schizophrenia patients teaching hospital. Prospective, observational, comparative study conducted for six months among Schizophrenia patients. The data was collected from 62 enrolled subjects with the help of questionnaires and scales, and data was analyzed by using a t-test and other relevant descriptive analysis by using the statistical software SPSS version 20.0. Out of a total of 70 patients, males were 39, andfemales were 31. Out of 70 patients, only 62 patients completed the study according to the inclusion criteria. The occurrence of schizophrenia was higher in the age of late adolescence and early adulthood. Risperidone was more effective in treating negative and general symptoms compare to chlorpromazine, but equally efficacious in treating positive symptoms. Poor medication adherence was found in patients receiving both drugs. Chlorpromazine is more effective in a patient with predominantly positive symptoms. Risperidone is more effective and should be preferred in patients with positive, negative, and general symptoms.
Evaluation of the antioxidant activity of various extracts of aerial parts of Cassia absus: An in-vitro techniques
Authors: Mythri M  , Sanal Dev K T  , Kottai Muthu A
Published: April 2020

Cassia absus (Linn)Cassia absus(Linn) (family Fabaceae ) is generally known as “chaksu ” inan ayurvedic traditional system.The current study,aerial parts of different concentrates(Pet.ether, ethyl acetate and methanol) of Cassia absus, was evaluated for its in-vitro antioxidant potential byDiphenylpicrylhydrazyl radical,nitric oxide activity andtotal antioxidant activitytaking ascorbate as the standardfor all the three methods. The IC50 value was originated that methanolic concentrates of Cassia absusmore efficient inDiphenylpicrylhydrazyl radical,nitric oxide activity, total antioxidant activitycompared EA&PEconcentrates.The methanolic concentrates of Cassia absus& ascorbic acid exhibited antioxidant potential possessing IC50230µg/ml &130µg/ml (Nitric oxide). 205µg/ml &57µg/ml (total antioxidant),195µg/ml & 66µg/ml (Diphenylpicrylhydrazyl radical)respectively. The difference in the scavenging potential of the extracts can be due to variation in the percentage of bioactive compounds present in different solvents. Invitroantioxidant studiesobviouslyshow the methanolic concentrates of Cassia absushave better antioxidant activity. This result indicates that aerial parts of methanolic concentratesCassia absuscould serve as a natural antioxidant, which may be useful in preventfree radical-induced diseases.
Carica Papaya Leaf Extracts: A Novel Herbal Drug in Cancer Treatment
Authors: R Rajashri , Neralla Mahathi , George Rinku , M P Santhosh Kumar , Balasubramaniam Arthi
Published: April 2020

With the continued increase in Cancer incidence and deaths, traditional clinical therapies like surgery, radiation, chemotherapy, immunosuppression alone are not enough to counteract cancer due to their cost and its associated side effects, thus emphasizing the need for a novel intervention plan. Hippocrates's (5th century BCE) quote "Let food be thy medicine, and let thy medicine be thy food" is well popular all over the world and thus food was chosen to enhance health and emotional wellbeing that caused the change in trend in the market for natural products that help in combating cancer. Cancer statistics showed that the consumption of diets rich in fresh fruits and vegetables is inversely associated with cancer incidence, which leads to study plant-based dietary antioxidants and its therapeutic role in cancer, which was underestimated in the past. This review is about the potential benefits of leaf extracts of Carica papaya in treating various cancers of the body; and its implication in the management of oral cancers.
Exploration of antifungal potential of different extracts of Zingiber officinale against Microsporum gypseum
Authors: Sudan Puneet , Goswami Manish , Singh Jitender
Published: April 2020

Ginger (Zingiber officinale) has been utilized since ancient times in various traditional systems of medicine like Ayurveda, Unani, and naturopathy because of antifungal and antimicrobial potential against diverse fungal and microbial infections.  Moreover,  in the Asian subcontinent like  India, Pakistan, Bangladesh, etc., ginger is used in many food preparations as a condiment and boiled decoction to treat cold-cough and indigestion. The present research was conducted to find out the antifungal potential of various extracts of dried ginger powder, by means of paper disc diffusion method, with petroleum ether, ethyl acetate, ethanol and aqueous solvents in 25 μml,50 μml and 100 μml concentrations against Microsporum gypseum. Clotrimazole was used as a standard. The present study revealed that ginger is a potent antifungal agent against Microsporum gypseum. The ethanol extract of ginger using 100 μml concentrations depicted the highest zone of inhibition of 19.840+ 0.65mm and 46.139% of mycelial inhibition against the tested pathogen. While other drug extracts in different solvents also revealed reasonable to least antifungal potential. This finding tells us that ginger extracts tested proved to be a potent antifungal agent against Microsporum gypseum.It was found that ethanol extract of ginger is best effective against tested strain. This exploration of ginger extracts has confirmed its importance, particularly in the area of influence on dermatophytic fungal strain.
Prevalence of Vitamin D Deficiency in Primary School Children with Developmental Coordination Disorder (DCD)
Authors: U Ganapathy Sankar , R Monisha , Vallaba Doss Christopher Amalraj , R M Palanivel
Published: April 2020

The majority of mothers and caregivers of children with DCD were not aware of vitamin D deficiency and its relations to cardiovascular abnormalities and many other non-skeletal abnormalities. It is well known that skeletal muscle integrity and metabolism are boosted by sunray vitamin and Young women’s and children were the victims of vitamin D deficiency. Vitamin D oral supplementation is under routine practice in a western country. However, it has been frequently documented in studies, but there are limited data on the prevalence of Vitamin D deficiency among children with DCD in the Indian population. The study aims to find out the prevalence of vitamin D deficiency in children with DCD in primary schools.20 children with DCDunderwent physical examination on the blood test and physical activity assessments.(50%) were vitamin D deficient (serum 25OHD level), of whom 4% were severely vitamin D deficient and physical activity were significant independent predictors of hypovitaminosis D. Indian mothers of children with DCD  were having poor perception regarding their child's green land play and they constrain the children's towards academic activities. Thus they were at higher risk of osteoporosis and osteopenia as there is a higher prevalence of vitamin D deficiency encountered in children with DCD.
The effect of polymorphism on active pharmaceutical ingredients: A review
Authors: Ainurofiq Ahmad , Dinda Kezia Esther , Pangestika Maya Widia , Himawati Ulia , Wardhani Wening Dyah , Sipahutar Yustika Tamarin
Published: April 2020

Active pharmaceutical ingredients (API) are the main components in the production process of pharmaceutical products. If the API has a good quality, then it will lead to good pharmaceutical products. API consists of more than one different crystal form which, then forms a polymorph through the process of polymorphism. Until now, API polymorphism is still a big challenge in the pharmaceutical industry. That is because the nature of polymorphism is difficult to predict. One of them is by crystallizing molecules in one or many crystalline forms or combining with other molecules to form stable co-crystal. This process will lead to several polymorph forms of one certain API. Sometimes, these forms will have characteristics that differ one to another. Each polymorph has different mechanical, physical, thermal, and chemical properties that will affect the solubility, dissolution, bioavailability, stability, bioequivalence, and manufacturing of the API. Therefore to know the nature of an API, it is necessary to characterize the polymorphic form of the API before. If the form is not incompatible with the formulation, it can cause a failure in the production process. This review will discuss the effect of polymorphism on the physicochemical properties of API. It is hoped that this review can become the basis for improving the stability and effectiveness of pharmaceutical products.
Antimicrobial and Enzymatic potential of Streptomyces sp. KAS-1 isolated from the microbiologically unexplored estuary of Kali river ecosystem
Authors: Nayaka Sreenivasa , Nagaraja Shashiraj Kareyallappa , Chakraborty Bidhayak , Bhat Meghashyama Prabhakara , Swamy Pallavi Sathyanarayana , Airodagi Dattatraya , Hiremath Halaswamy , Rudrappa Muthuraj , Basavarajappa Dhanyakumara Shivapoojar , Pednekar Anusha Rohidas
Published: April 2020

In the present study, a Streptomyces sp. was isolated from sediment soil samples of the Kali river estuary, Karwar, Karnataka, India. The isolated Actinomycetes strains were screened against pathogenic microorganisms and for the production of hydrolytic enzymes. Later, the strongest strain Streptomyces sp.KAS-1 was taken for further analysis based on primary characterizations. The morphological, physiological and biochemical characterizations of Streptomyces sp.KAS-1 were carried out, followed by molecular characterization through 16S rRNA gene sequencing. The 16S ribosomal RNA gene sequencing and analysis of the phylogenetic tree showed a 98.97%sequence similarity with Streptomyces thermocarboxydus strain SDT64(KJ018992). Finally, the intracellular methanol extract was characterized through UV-Visible and FTIR spectrophotometer. The Streptomyces sp.is a gram-positive, aerobic, non-motile, spore-forming bacterium and it was designated as Streptomyces sp.KAS-1 and was found to possess a strong antimicrobial activity against pathogenic microorganisms. The characterizations revealed the Streptomyces sp.KAS-1was moderately thermophilic, neutrophile organism having the capacity to degrade a broad range of carbon sources. The UV-Visiblespectrum ofmethanol extract of Streptomyces sp.KAS-1revealed the presence of Muconomycin-Band the presence of different functional groups such as aldehydes, amines, and alkyl halides were indicated by the FTIR spectrum.
试论如何加强道路与桥梁现场施工管理
Authors: 邓 耀承 , 曾 娜
Published: April 2020

中国的道路以及桥梁施工现场规模都相对比较大，特别是在施工的过程当中资金投入量较高，受到了管理人士的高度关注。随着中国经济的发展，城市进程也不断加快，在中国城市发展的过程中，道路与桥梁工程逐渐趋于主导地位，但在发展的过程中，依旧存在一些隐患，无论是技术方面还是质量管理方面，都逐渐成为社会关注的重点。为了有效的保障桥梁以及道路施工现场管理科学性以及有效性，需要采取行之有效的管理方式，切实保障流程得到优化。论文主要是关于提高桥梁道路现场施工管理水平的研究，以供相关专业人士进行参考和借鉴。
Caracterização microbiológica e físico-química do leite cru refrigerado durante o tempo de armazenamento na propriedade
Authors: Frizzo Adriane Ferreira , Andrighi Daniela , Starikoff Karina Ramirez
Published: April 2020

No presente trabalho objetivou-se avaliar a qualidade microbiológica e físico-química do leite cru refrigerado proveniente de 10 propriedades leiteiras do município de Realeza – PR. Foram realizadas análises microbiológicas de contagem de microrganismos aeróbios mesófilos, psicrotróficos, colônias proteolíticas e lipolíticas e análises físico-químicas de pH, densidade, acidez Dornic, extrato seco, gordura e proteína. Os resultados obtidos foram submetidos à análise estatística de Tukey a 5%. As principais alterações físicoquímicas observadas nas amostras avaliadas foram a diminuição do pH, o aumento da acidez Dornic e a diminuição nos teores de gordura da primeira para a segunda coleta em algumas amostras. Quanto às contagens de microrganismos, os aeróbios mesófilos se mantiveram dentro do estabelecido na legislação vigente. Enquanto nos psicrotróficos, e nas colônias proteolíticas e lipolíticas de algumas amostras o crescimento foi superior ao recomendado pela literatura. Conclui-se que as amostras avaliadas apresentaram poucas alterações microbiológicas e físico-químicas durante o período de armazenamento, porém é de grande importância a análise frequente do leite em busca de microrganismos que possam alterar a sua composição.
KÜÇÜK VE ORTA ÖLÇEKLİ İŞLETMELERDE KRİZ: ADIYAMAN ORGANİZE SANAYİ SİTESİ ÖRNEĞİ
Authors: SARSICI Erkan
Published: April 2020

Adıyaman organize
sanayi sitesinde faaliyet gösteren KOBİ’lerin kriz yönetimine yönelik kriz
öncesi, kriz anı ve kriz sonrası herhangi bir çalışma yapıp yapmadıkları
araştırılmıştır. Araştırma kapsamına alınan 353 KOBİ niteliğine sahip
işletmeler araştırmanın ana kütlesini oluşturmaktadır. Bu bağlamda yüzyüze
anket yöntemi ile 175 şirkete ulaşılmış olup, konuya ilişkin kullanılan
ölçeklerin geçerlilik ve güvenilirliği test edilmiş, korelasyon ve faktör
analizi uygulanmıştır. Araştırma sonuçlarına göre KOBİ’ler tarafından kriz
öncesi, kriz anı ve kriz sonrasında gerekli çalışmaların yapılmakta olduğu
görülmektedir. Bu kapsamda ilişkisel alt boyutlar (p<0,05) ile kriz yönetimi
arasındaki ilişki yapılan istatistiksel araştırmalar sonucunda anlamlı
bulunmuştur.
ALL OPTICAL REVERSIBLE DATA DISTRIBUTOR
Authors: K Sathish , R Aswinkumar , T Theresal , S Dhanabal
Published: April 2020

Nowadays, It became the fashion among the researchers about creating the New Reversible Gates. In the Reversible Literature, already many gates are proposed but it is the first time to propose a Gate for a decoder(Data Distributor). The proposed GLG (Garbage Less Gate) has No Garbage output which denotes its power efficiency. In this paper 2:4 reversible decoder is constructed using GLG. The proposed gate is also extended to N:2N decoder using the proposed GLG Gate and the Fredkin Gate. The theoretical proposition is verified through Optisystem & Modelsim Software. A comparison with existing reversible decoders is also included.
DEVELOPMENT OF PID LIKE FLC ALGORITHM FOR INDUSTRIAL APPLICATIONS
Authors: Rana Sudesh
Published: April 2020

Now a day, in many industries different types of controllers (PD, PID, PLC, FLC etc.) are used. One of them is fuzzy logic controller. Here we develop a PID like fuzzy logic controller for industrial application, such application is water purification plant. For developing the PID like FLC, first we have to design a PID algorithm than we develop an algorithm for fuzzy logic controller. By comparing this two of controller we will develop a PID like FLC. A simple PID controller is sum of three type of controller proportional, integral and derivative controller, after simulated on MATLAB. Same cases we can be develop a structure of FLC for water purification plant. In the water purification plant raw water or ground water is promptly purified by injecting chemical rates at rates, related to water quality [13][2]. The feed of chemical rate judged and determined by the skilled operator. Here we try to develop an FLC algorithm so that the feed rate of coagulant is can be judged automatically without any skilled operator, than compose a PID like FLC for water purification plant process.
Analysis of Land Uses In Iraqi Cities
Authors: Nabil T. Ismael  , Areej Muhy Abdulwahab
Published: April 2020

Abstract—Land use plans in Iraqi cities are traditional and don’t seek to be sustainable and therefore could have negative impacts on the city from the environmental, economic, social and urban aspects. Consequently, the research aims to analyze the current and future of the land use for a set of Iraqi cities to reach the indicators of the gap between traditional and sustainable plans when planning for land uses. 

The research conclusion is that most Iraqi cities are highly urban sprawl, both in reality and in the future expansion of the city. That is because it consumes a lot of agricultural land, cities with low population densities that are unsustainable, and most land uses are unsustainable focusing on reducing the agricultural and green lands in the city and increase residential uses (single type with very low density), and expand the areas of the streets that depend on the automated transportation more than sustainable transportation. 

The research suggests that sustainable land uses in Iraqi cities should be as follows: 

 Residential use: vertical housing pattern 30 %, horizontal housing pattern 15 %. 

 Mixed use 12 %. 

 Green, open and recreational areas 22 %. 

 Sustainable transport 13 %. 

 Public, community and government services 8 %.
Administrasi Layanan Khusus
Authors: riska Seiski afrita
Published: April 2020

Special service administration is to provide special services or a business that is indirectly related to the learning process of teaching field of boarding services. Types n class but specifically given by schools to their students so that they are more optimal in implementing the learning process. The role of the teacher is needed in the administration of special services, on of which is in the special field of boarding services. Types of special services such as transportation, school cafetarian and so on.
ALENDA NOVIANDRI 175100016 TUGAS AUDIT
Authors: Noviandri Alenda
Published: April 2020

Audit merupakan suatu proses terpadu mengenai pengumpulan, penilaian danpengujian atas aktifitas suatu kegiatan. Audit Sistem Informasi merupakan prosesterpadu kegiatan yaitu melakukan pengumpulan, penilaian dan pengujian atasaktifitas kegiatan di lingkungan Sistem Informasi.Dengan mengacu pada COBIT(Control Objective for Information and Related Technology) dapat digunakan sebagaialat yang dapat digunakan untuk mengefektifkan implementasi sistem informasidalam perusahaan. COBIT terdiri dari 4 (empat) domain, yaitu PlanningOrganization, Acquisition-Implementation, Delivery-Support dan Monitoring.COBITframework digunakan untuk menyusun dan menerapkan model audit systeminformasi dengan tujuan untuk memberikan masukan dan rekomendasi bagi pihakmanajemen perusahaan untuk perbaikan pengelolaan sistem informasi (ITGovernance) di masa mendatang
Audit Sistem Informasi Absensi pada PT. Bank Central Asia Tbk menggunakan COBIT 4.1
Authors: christian anton
Published: April 2020

AbstractBCA is a national bank established in 1957 and hascontinued to grow. Nowadays the bank hassupported business processes in various companies,such as the use of attendance information systems.During this system implementation, it has beenrunning to support the procedures of attendanceactivities. The purpose of this research is to get anoverview of the performance of informationtechnology governance in order to determine theextent of maturity level which is currently running,with a few aspects to consider such as effectivenessand, efficiency. The conclusion that can be drawnfrom the research that has been done is ITgovernance at the BCA has been done, althoughstill run optimally within each IT process containedin the sub domain Monitor Evaluate Assess (MEA)on average was at 3.0 (defined process) for subdomain DS1, DS5, DS10 and ME2.
Molecular Docking Study of drug molecules from Drug Bank database against COVID-19 Mpro protein
Authors: Joshi Tushar , Mathpal Shalini , Sharma Priyanka , Joshi Tanuja , Pundir Hemlata , Maiti Priyanka , Nand Mahesha , Chandra Subhash
Published: April 2020

Aims: SARS-CoV-2 which is NovelCoronavirushas been disseminated all over the world and causing Coronavirus disease (COVID-19) resulting in many deaths as well as economic loss in several countries.This virus is showinga considerable amount of high morbidity and mortality.Currently, no drugs are available againstSARS-CoV-2. Therefore,for the treatment of disease, researchers are looking fornew drugs that can treat the disease and prevent it to be spread.In this regard,drug repurposingmay help scientists for treating and preventing infections associated with SARS-CoV-2. Drug repurposingis a strategy that can identify new targets for existing drugs that are already approved for the treatment of a disease.Main methods: In this study, we present a virtual screening procedure employing deep lerning regression method in 9101 drugs from Drug bank database against the target Main protease (Mpro) for the treatment of COVID-19. 500 screened compounds were subjected to docking.Key findings: Among those 500 drugs, 10 best drugs were selected, which had better binding energy as compared to the reference molecule. Based on the Binding energy score, we can suggest that the identified drug may be considered for therapeutic development against the virus.Significance: Drug repurposing has many advantages as it could shorten the time and reduce the cost of new drug discovery. This research will help to get new drugs against COVID-19 and help humans against this pandemic disease. Keyword- Drug Repurposing, Deep learning, Molecular Docking, COVID-19, Drug bank database, MPro
Nature or Nurture Controversy in Aporia bieti recognize flower color
Authors: JIMIN HAN
Published: April 2020

Nature refers all hereditary factors that influence animal and becoming a part of physical appearance，but nurture refers to all the environmental variables and is a print got from experiences. We take a comparative approach and study behaviors. Butterflies are insects who is very smart insects that can observe flower color and Aporia bieti, what we research in the field, visual processing of color stimuli by a flower dish smelling of honey, the methods used in observation in the field without interference from the observer. According video we find that Yellow flower is the most prefer flower color for butterfly. Some researcher places more emphasis on butterflies’ instinct and natural behavior, and they found recognize yellow flower pattern is fixed action patterns. And fly to yellow flower groups seems a predictable response to stimulus sunny meadow in Xiama Forest Farm, where are yellow flower located.The dishes design is a goal to make research more rigorous. What’s more, we design this is intended to let more researchers design another insect or animal color preference in the field. We design cubic model in order to explore more in nature or nurture controversy in recognize color in the filed.
RF- EMR – Effects on human and environmental health
Authors: Biju Bincy , Sarkar Chiradeep
Published: April 2020

In today's world, development in technology has brought social and economic benefits to society and technological devices play a vital role in our day-to-day life. However, with advancement in the field of electronics and communication technology, there is an increased risk of exposure to electromagnetic field and this may cause many health problems in humans as well as affecting the environment. Sources of electromagnetic waves are power transmission line, base transmitter station, mobile phones, household appliances and the waves that are emitted from these sources get absorbed in the body causing various ill-effects. Various studies have shown that radiations from mobile phone/towers increases the rate of various types of cancer among women and children. Electromagnetic radiations can also cause changes in EEG pattern, decrease in TSH, T3, T4, prolactin, testosterone, estrogen and progesterone levels. Experimental studies showed that long- term exposure to electromagnetic waves decrease sperm count and quality among men. RF- EMR can cause DNA damage, affect embryo viability and cause premature birth. In this narrative review, we focus on the available literature describing the ill-effects of various kinds of electromagnetic radiation emitting sources on multiple organs/organ systems of the human body as well as its effect on the environment from studies carried all across the world.
AUDIT SISTEM INFORMASI AKADEMIK BERBASIS WEB MENGGUNAKAN FRAMEWORK COBIT 5.0 PADA DOMAIN APO13 DAN DSS05
Authors: Tubagusakbar.student
Published: April 2020

Audit itu sendiri merupakan DATA PROCESSING atau umumnya sering kita sebut dengan pengecekan DATA pada tiap tiap Instansi ataupun Kantor/perusahaan terkait yang dimana AUDIT ditunjuk untuk melakukan pengecekan DATA mengumpulkan DATA mengevaluasi DATA yang sesuai.
THE CAVE CHAPTER: A VICTORY PACKAGE FOR THE MUSLIM SOCIETY
Authors: Ali Abdella Yimam
Published: April 2020

Sura al-Kahf mostly regarded as a chapter of the Quran which comprises the past stories such as the people of the cave, Moses and Khedir (a.s), and Dhul Qarnain, etc. However, careful examination of the chapter indicates the fact that Sura al-Kahf is not a history chapter rather it is a victory package for Muslims. This paper explains Sura al-kahf in this context.
TUGAS RESUM AUDIT MUHAMMAD GANTHA NUGRAHA (175100063)
Authors: nugraha Muhammad gantha
Published: April 2020

Perusahaan memerlukan jasa auditor untuk melakukan audit atas laporan keuangan. Jasa dari auditor independen digunakan manajemen perusahaan untuk menyakinkan pihak luar seperti investor dan kreditor bahwa laporan keuangan yang disajikan berisi informasi yang dapat dipercaya. Akuntan publik harus meningkatkan kinerjanya agar dapat menghasilkan produk audit yang dapat diandalkan perusahaan.
Does Maximizing Good Make People Look Bad?
Authors: Montealegre Andres , Bush Lance S. , Moss David , Pizarro David Alexander , Jimenez-Leal William
Published: April 2020

Despite the potential to significantly increase the impact of donations, people often fail to prioritize the cost-effectiveness of charities. This paper examines an explanation for why people may donate less effectively due to reputational concerns that favor approaching donations by empathizing with the recipients of the donation rather than deliberating about the cost-effectiveness of charities. Across seven studies, we find that “deliberators” are perceived as less moral and less desirable as social partners than “empathizers”. Moreover, people accurately anticipate the reputational costs associated with deliberation and are more likely to donate to empathic but less effective causes when reputational concerns are salient. Our findings suggest that there are disincentives for selecting charities by deliberating about their cost-effectiveness, as people are more rewarded for signaling socially valued moral traits than for prioritizing charitable impact.
An introduction to linear mixed effects modeling in R
Authors: Brown Violet Aurora
Published: April 2020

This tutorial serves as both an approachable theoretical introduction to mixed effects modeling and a practical introduction to how to implement these models in R. The intended audience is any researcher who has some basic statistical knowledge, but little or no experience implementing mixed effects models in R using their own data. In an attempt to increase the accessibility of this paper, I deliberately avoid using mathematical terminology beyond what a student would learn in a standard graduate-level statistics course, but I reference articles and textbooks that provide more detail for interested readers. This tutorial includes snippets of R code throughout, as well as the data and R script used to build the models described in the text so readers can follow along if they wish. The goal of this practical introduction is to provide researchers with the tools they need to begin implementing mixed models in their own research.
Conceptualisation of parenting in research on young children with or at elevated likelihood of autism: A systematic review of observational measures
Authors: Madarevic Melinda , Van Leeuwen Karla , Warreyn Petra , Noens Ilse
Published: April 2020

Research on emergent autism spectrum disorder increasingly uses observational measures to investigate parenting of young children with or at elevated likelihood of autism. This systematic review analysed 21 papers narratively, including 13 unique “coding approaches” and 63 parenting constructs. Through a comprehensive consensus decision-making process, parenting constructs were classified under nine overarching categories, identified based on prior categorisation: Warmth, Responsiveness, Scaffolding, Proactive Control, Intrusiveness, Negativity, Dyad, Other, Multiple. We found large heterogeneity in observational measures, and descriptions of parenting constructs lacked uniformity. The complex categorisation process demonstrates the need for a solid conceptual framework that can inform theory and practice. This review provides a first step, but further research should investigate applicability among young children of different ages.
An Essential Service Decision Model for Applied Behavior Analytic Providers During Crisis
Authors: Colombo Richard , Wallace Michele , Taylor Rachel S.
Published: April 2020

In the United States, applied behavior analysis (ABA) is broadly recognized as a medically necessary treatment for individuals diagnosed with autism and related disorders (Association of Professional Behavior Analysts, 2020). We argue that this designation should not be called into question in the light of a particular disaster and that it is critical to consider that an interruption of services can have long-lasting effects on the treatment of the individual (practitioners are ethically obligated to uphold the continuity of services while doing no harm). This dilemma might be ameliorated by a decision model that considers the prioritization of immediate needs, vulnerability of clients, and competency of service providers. Just as the medical field prioritizes immediate needs during crisis situations and defers routine appointments (e.g., physicals, check-ups, etc.), the ABA field can make similar evidence-based decisions. The purpose of the current paper is to provide a decision model for ABA practitioners who find themselves questioning the need for essential service delivery during the current Coronavirus (COVID-19) pandemic. The impact of this model goes beyond the needs of this crisis and can be applied to any emergency situation where services are at risk of interruption.
Reinert, Higbee, and Nix-Criando Rotinas de Atividades Digitais
Authors: Higbee Thomas
Published: April 2020

Demonstrou-se que os rotinas de atividades fotográficas são eficazes para ajudar indivíduos com autismo e outras deficiências de desenvolvimento a aprender como concluir sequências simples e complexas de atividades sem a orientação dos adultos. Embora a maioria dos estudos que demonstrem a eficácia das rotinas de atividades usem agendas compostas por imagens estáticas impressas anexadas a páginas físicas, recentemente, os pesquisadores começaram a demonstrar a eficácia das rotinas de atividades baseados em tecnologia. No artigo atual, fornecemos uma análise de tarefas para criar rotinas de atividades digitais simples e complexas usando o Google Slides, uma tecnologia baseada na Web disponível gratuitamente que opera em uma variedade de plataformas digitais. Também fornecemos sugestões de como os analistas de comportamento podem treinar os pais para usar essa tecnologia com seus filhos usando procedimentos de tele-saúde.
Memory of the UK’s 2016 EU Referendum: The effects of valence on the long-term measures of a flashbulb memory.
Authors: Raw Jasmine , Rorke Alice , ELLIS JUDITH ANN , Murayama Kou , Sakaki Michiko
Published: April 2020

Emotional public events, relative to non-emotional ones, are typically remembered more accurately, more vividly and with more confidence. Such memories are referred to as flashbulb memories. However, the majority of previous studies on this phenomenon have focused on negative public events and less is known about positive ones. The current study examined whether positive and negative public events were remembered in a similar manner by assessing individuals’ memory for the time when they learned the results of the UK’s 2016 Referendum on its European Union (EU) membership. Participants included UK residents who voted to ‘leave’ the EU in the referendum and found the event highly positive, UK residents who voted to ‘remain’ in the EU and found the event highly negative, and US residents who did not vote and found the event neutral. Data from a total of 845 participants were assessed at four time points over the course of 16 months. Growth curve modelling showed that differences in memory between Remain voters (who reported the highest levels of negative emotion) and Leave voters (who reported the highest levels of positive emotion) emerged over time. Specifically, Remain voters maintained higher levels of memory consistency than Leave voters, while Leave voters maintained higher levels of memory confidence than Remain voters. These results indicate that positive and negative public events are remembered differently, such that negative valence enhances memory accuracy, while positive valence results in overconfidence.
Virtuous Victims
Authors: Jordan Jillian , Kouchaki Maryam
Published: April 2020

How do people perceive the moral character of victims? We find, across a range of transgressions, that people frequently see victims of wrongdoing as more moral than non-victims who have behaved identically. Across 17 experiments (total n = 9,676), we document this Virtuous Victim effect and explore the mechanisms underlying it. We also find support for the Justice Restoration Hypothesis, which proposes that people see victims as moral because this perception serves to motivate punishment of perpetrators and helping of victims—and people frequently face incentives to enact or encourage these “justice-restorative” actions. Our results validate predictions of this hypothesis, and suggest that the Virtuous Victim effect does not merely reflect (i) that victims look good in contrast to perpetrators, (ii) that people are generally inclined to positively evaluate those who have suffered, or (iii) that people hold a genuine belief that victims tend to be people who behave morally.
Contrasting shared- and specific-mechanism accounts of developmental prosopagnosia: A new approach
Authors: Gerlach Christian , Susilo Tirta , Barton Jason J. S. , Albonico Andrea , Malaspina Manuela , Starrfelt Randi
Published: April 2020

The understanding of developmental prosopagnosia (DP) is dominated by two opposing views: (i) that DP reflects malfunction of a mechanism shared by face and object recognition, but which is more critical for face than for object recognition, or (ii) that DP is due to malfunction of a mechanism specific to faces, but where object recognition deficits may co-occur due to collateral damage. Here we address some of the limitations in DP studies on this point by examining face and car recognition in a large cohort of healthy subjects selected in an unbiased manner. At the group level we find evidence of a general association between face and car recognition performance but at the individual level we also find occasional dissociations. We discuss the methodological implications of these findings for cognitive neuropsychology in general (association vs. dissociation) but also the theoretical implications for the current understanding of DP more specifically.
Friendly Persuasion is Not Enough: The Limits of the Lansdale Approach
Authors: Ladwig Walter
Published: April 2020

Providing aid and advice to local governments’ counterinsurgency campaigns, rather than directly intervening with American forces, has recently been identified as a more cost-effective way to counter irregular threats to U.S. interests. The challenge that such undertakings have repeatedly faced in the past is that partner governments often have their own interests and priorities which can diverge significantly from those of Washington. Consequently, a host of observers have pointed out that while the United States has provided its partners with extensive assistance to combat insurgents and terrorist groups, an inability to convince them to adopt its counterinsurgency prescriptions or address what Washington sees as the political and economic “root causes” of a conflict has repeatedly emerged as a major impediment to success. In the absence of sufficient influence to convince a local government to address these shortcomings, critics suggest that significant American aid and support can actually reduce its incentives to address domestic discontent or govern inclusively, which can render a supported regime less stable than it would have been without U.S. assistance
Special Issue: Communicative Socialism/Digital Socialism, edited by Christian Fuchs (DOWNLOAD FULL ISSUE)
Authors: Fuchs Christian
Published: April 2020

Christian Fuchs, ed. 2020. Communicative Socialism/Digital Socialism. tripleC: Communication, Capitalism & Critique 18 (1): 1-285.Full volume for download
Temperature influence on the diethylamine sensing abilities of CuO nanoparticles deposited by atmospheric pressure plasma
Authors: Filipič Gregor , Gruenwald Johannes
Published: April 2020

In this work we present a copper oxide nanostructured analysed as a gas sensor but the focus of the paper is on the temperature dependance of the sensor sensing properties. As a case study temperature dependent diethylamine sensing is presented.The CuO nano flakes were deposited and evenly distributed on intercalated electrodes by an atmospheric pressure plasma source. The sensor was electrically connected to ohmmetre and inserted in an oven chamber where it was isolated from atmosphere and heated to desired tempearuteres. The intrinsic resistnace of the sensor was measured in dependence of the temperature and the temperature change rate. Then the possibility to detect diethylamine was investigated and the sensor response studied. Finally, the temperature dependence of the detection of the amine was explored. It was possible to demonstrate reliable sensing of the amine down to temperatures of 100 °C and below.
How do Students Self-Esteem and Attitude to Learning English Relate to Classroom Learning Environment?
Authors: Siddiqui Ghazal Khalid , Lodhi Huma , Anwer Muhammad
Published: April 2020

This study investigates the correlation of secondary level learners attitudes for learning English and self-esteem with the classroom learning environment. From Punjab Province, 1002 public secondary school respondents formed the population. The sample consisted of males (486), females (516), urban (565) and rural (437) and was selected from two districts (Lahore and Kasur). Instruments namely WIHIC (Fraser, 2007), attitude towards learning English (Batool, 2016) and students self-esteem (Rosenberg,) scales having reliability 0.91, 0.83 and 0.68 (in Pakistani context) respectively, were used. Findings exposed a significant and more positive attitude for learning English among female respondents. Correlation (Pearson r) between the learning environment and attitude for learning English revealed no significant results at gender basis while on locale basis urban respondents showed significant correlation. The gender-based difference showed girls had more self- esteem than boys. Rural participants had more self-esteem concerning urban respondents.