bluuebunny/crossref_metadata_2025 huggingface dataset:
Novel Bone Void Filling Cement Compositions based on Shell Nacre and Siloxane Methacrylate Resin: Development and Characterization
Authors: W Bridget Jeyatha , P.P. Lizymol
Published: May 2023

Shell nacre from Pinctada species has been extensively researched for managing bone defects. However, there is a gap in the research on using shell nacre as cement with improved physico-chemical properties. To address this, the current study aimed to develop a chemical curable com-posite shell nacre cement (SNC) using shell nacre powder and an organically modified ceramic resin shell nacre containing ladder-structured siloxane methacrylate (SNLSM). Different amounts of shell nacre (24, 48, and 72 weight(wt)%) were added to the SNLSM resin matrix and the effect on the physicochemical properties of the cement was studied. The composite shell nacre cement SNC 72 containing 72 wt% shell nacre exhibited significantly higher mechanical properties (com-pressive strength >100 MPa, flexural strength > 35 MPa) and low linear polymerization shrinkage (0.4%) than other compositions. SNC 72 was radiopaque and the exotherm generated during the curing of the cement was minimal. Direct contact of cured SNC 72 with L929 cells revealed the non-cytotoxic nature of the cement. Overall, the results of the study proved that the composite SNC 72 would be a promising candidate for bone defect management.
Los aprendizajes y la política educativa en la educación virtual, en las escuelas públicas peruanas, durante la pandemia por el COVID19
Authors: Liberato Lucas Palacios , Alvarado Mónica
Published: May 2023

El Objetivo de la presente es describir la contradicción ineludible que existe entre la política educativa oficial del Estado peruano y la práctica pedagógica de los docentes en sus lecciones, asumidas y desarrolladas en las escuelas públicas durante la pandemia por el COVID19, entre los años 2020 y 2021; ya que, por un lado las normas educativas han falsificado completamente la modalidad de educación virtual, a distancia o remota, en contra de la concepción pedagógica del profesional docente preocupado por los aprendizajes. La Metodología describe por un lado la experiencia docente, tal cómo “debe ser” la práctica pedagógica en una verdadera educación a distancia, virtual o remota, frente al conjunto de deficiencias generados por las normas educativa que el Estado, como el fracaso del programa denominado “Aprendo en casa”. Esta presenta los Resultados negativos desde el lado del sistema oficial, expresados en el deterioro de los aprendizajes de los educandos, y, por otro lado, describe la estrategia didáctica del docente abstrayéndose de la política educativa oficial, basado en un sistema de tareas escolares como parte de las lecciones con el grupo de educandos a su cargo. En Conclusión, nuestra experiencia demuestra la contradicción insalvable entre la política educativa oficial y la metodología del docente en sus lecciones adecuadas y pertinentes a una verdadera educación virtual, remota o a distancia, tendientes a mejorar los aprendizajes y/o desarrollo de las competencias del educando.
Kajian Penerapan Pendekatan Arsitektur Regionalisme pada Museum Batik Surakarta
Authors: Widodo Anisa Desita , Agustin Dyan
Published: May 2023

Batik museum is a place to preserve batik as part of the Indonesian local culture in the future. Currently, several batik-producing cities have their own batik museums, one of which is the Surakarta Batik Museum. The building uses a regionalism architectural design approach that is relevant to its function, namely elevating the local culture of Surakarta. The successness in applying the regionalism architectural approach can be seen in the implementation of building elements. This study aims to examine the successful application of the regionalism architectural approach to the Surakarta Batik Museum which is based on three regionalism architectural factors. The research uses qualitative methods with the acquisition of primary data and secondary data. The results of this study explain the success in applying the regionalism architectural approach to the Surakarta Batik Museum.
Structural Logic of Umah Kantur Gayo Construction Elements
Authors: Nursaniah Cut , Fadillah Muhammad Zairi , Djamaluddin Masdar
Published: May 2023

Umah kantur in the Gayo highlands is located in the Bukit Barisan section which is crossed by the Sumatran fault line, making this area prone to earthquakes. These vernacular houses were designed by local people using natural materials found in their environment, forming a hazard-responsive system of wooden construction. However, the current generation tends to forget this knowledge from their ancestors, why this construction was used and what is the logic of the structure in the building. This qualitative research observes to identify the construction process of the elements and joint systems of the umah kantur in the Pegasing-Gayo area. The results of the study concluded that the home construction system contains sustainability to be applied to the current simple wooden house construction. The use of nails in the construction of walls, zinc material for roof, and cast concrete for bases, is still capable of producing a construction that is rigid elastic, lightweight, and able to reduce earthquake forces. Evidenced by the occurrence of uniform swaying movements of the legs, body and head construction during an earthquake, so that the house is still sturdy today.
Filosofi Sunda dalam Konsep Lanskap Bangunan Kolonial di Kota Bandung
Authors: Izzati Husna , Andiyan Andiyan , Darwin Wowo Adizar
Published: May 2023

Bandung has a unique landscape and is also a historic city with colonial architectural characteristics. The formation of Bandung City, could not be separated from the influence of colonialism, marked by the construction of Jalan Raya Pos. Colonial city planning was carried out by making a master plan, some with the south-north axis of the landscape concepts, but philosophically the south-north axis has been applied since the Regent of Bandung built the pendopo area. This fact raises the question of whether the concept of colonial buildings also adopts the concept of Sundanese philosophy. This study uses a qualitative method with a descriptive approach and inductive logic analysis to produce generalized conclusions. From the results of this study, it was found that there was an influence of environmental contextual aspects, considerations of morphological forms, and political aspects in designing the landscape of colonial buildings in Bandung city. 
Manfaat dan Tantangan Penggabungan Pengukuran Objektif dan Subjektif dalam Penelitian Arsitektur
Authors: Sabono Ferdy , Sudradjat Iwan , Widiastuti Indah
Published: May 2023

Inaccuracy in choosing and using the type of measurement will result in biased research findings. Measurements commonly used in architectural research are objective, subjective, or objective-subjective (mixed) measurements. This article will discuss mixed measures (objective and subjective) in architectural research. Researchers can analyze field data using a quantitative approach, while subjective measurement data are analyzed using a qualitative approach. The results of the interpretation of the two types of measures can show convergence or divergence. This article aims to reveal the benefits and challenges of combining objective and subjective measurements in architectural research, based on systematic literature reviews in scientific journals, which have successfully used objective-subjective measurements and outlines the various benefits and challenges. This study shows that using objective-subjective measures in architectural research can be beneficial if done in an appropriate context.
Cryptocurrency: Highlighting the Approach, Regulations, and Protection in Indonesia and European Union
Authors: Tauda Gunawan A. , Omara Andy , Arnone Gioia
Published: May 2023

The speed of the adoption and use of cryptocurrency that utilizes blockchain technology as its central infrastructure is expanding globally, including in Indonesia. It has promising prospects as a future asset and payment instrument. However, the regulations in Indonesia are often delayed and inadequate for dealing with cryptocurrency's developments. This research is intended to analyze the approaches, regulations, and protection of the use of cryptocurrency. This study argues that the regulatory approach to using cryptocurrency is balanced, while Indonesia has a partial status in cryptocurrency legality. The government’s protection of cryptocurrency investors is adequate in using cryptocurrency as a commodity traded on futures exchanges with a license from Bappebti. A progressive policy for establishing the Digital Asset Law by the government is important due to the resultant clarity in the regulatory status of cryptocurrency will allow the ecosystem to grow and promote innovation, thus harnessing the benefits of cryptocurrency while mitigating related risks.
PERAN HUKUM PIDANA DALAM PEMBERANTASAN TINDAK PIDANA NARKOTIKA
Authors: Supanto , , Parwitasari Tika Andarasni , Sulistyanta , , Budyatmojo Winarno , Ismunarno , , Setiyanto Budi , Slamet Sabar
Published: May 2023

Abstrak

Kegiatan pengabdian masyarakat ini adalah mensosialisasikan Undang-Undang Nomor 35 Tahun 2009 tentang Narkotika kepada para guru dan siswa di SMA Muhammadiyah 1 Karanganyar. Kegiatan ini bertujuan untuk mencegah para siswa melakukan penyalahgunaan narkotika. Maraknya penyalahgunaan narkotika di kalangan para generasi muda termasuk para siswa sekolah, baik sebagai pengguna maupun sebagai pengedar. Oleh karena itu, untuk mencegah semakin banyaknya pengguna narkoba di kalangan pelajar, maka perlu dilakukan sosialisasi bahaya penyalahgunaan narkotika. Metode kegiatan pengabdian ini berbentuk penyuluhan hukum Undang-Undang Nomor 35 Tahun 2009 tentang Narkotika, yang dilanjutkan dengan dialog interaktif seputar narkoba antara para siswa dengan tim penyuluh hukum yakni para Dosen Bagian Pidana Fakultas Hukum Universitas Sebelas Maret. Narkoba dari segi agama sudah pasti adalah sesuatu yang haram, dan dari segi masa depan sebuah bangsa, narkoba adalah senjata paling ampuh untuk menghancurkan sebuah negara. Diharapkan dengan adanya kegiatan penyuluhan hukum ini, semakin banyak pelajar yang memiliki wawasan tentang bahaya narkoba.

Kata kunci : Undang-Undang Narkotika, narkoba, pelajar, penyuluhan hukum

Abstract

This community service activity is to socialize Law Number 35 of 2009 concerning Narcotics to teachers and students at SMA Muhammadiyah 1 Karanganyar. This activity aims to prevent students from abusing narcotics. The rise of narcotics abuse among the younger generation, including school students, both as users and as dealers. Therefore, to prevent the increasing number of drug users among students, it is necessary to socialize the dangers of narcotics abuse. The method of this service activity is in the form of legal counseling on Law Number 35 of 2009 concerning Narcotics, which is followed by an interactive dialogue about drugs between students and the legal advisory team, namely the Lecturers of the Criminal Section of the Faculty of Law, Sebelas Maret University. Drugs in terms of religion are definitely something that is forbidden, and in terms of the future of a nation, drugs are the most powerful weapon to destroy a country. It is hoped that with this legal counseling activity, more students will have insight into the dangers of drugs.

Keywords: Narcotics Law, drugs, students, legal counseling
PIDANA BAGI PELAKU TINDAK PIDANA KORUPSI BANTUAN SOSIAL DI MASA PANDEMI COVID-19
Authors: Kautsar Firzatulloh Irhab , Ismunarno '
Published: May 2023

Abstrak: Penelitian ini bertujuan untuk mengetahui aturan hukum pidana bagi pelaku tindak pidana korupsi bantuan sosial di masa pandemi COVID-19 dan mengetahui jenis pidana yang tepat terhadap pelaku tindak pidana korupsi bantuan sosial di masa pandemi COVID-19. Penelitian ini merupakan penelitian hukum normatif, bersifat perspektif dengan menggunakan bahan hukum primer maupun sekunder yang kemudian dianalisis dengan menggunakan metode penalaran logika deduktif. Teknik pengumpulan bahan hukum yang digunakan adalah studi kepustakaan yang relevan dengan topik pembahasan dalam penelitian. Hasil penelitian diperoleh bahwa pengaturan terhadap pelaku tindak pidana korupsi bantuan sosial di masa pandemi COVID-19 beserta ancaman pidananya telah diatur dalam beberapa peraturan perundang-undangan, seperti dalam UU PTPK, UNCAC dan UU TPPU. Jenis pidana yang dijatuhkan kepada pelaku korupsi haruslah dapat memberikan efek jera dan mengembalikan harta kekayaan yang telah diperoleh oleh pelaku korupsi kepada negara. Korupsi yang dilakukan oleh penyelenggara negara terhadap dana pengadaan bantuan sosial di masa pandemi COVID-19 sudah seharusnya menjadi pertimbangan hakim dalam menjatuhkan pidana maksimum.

Kata kunci: Aturan Hukum Pidana, Jenis Pidana, Pandemi COVID-19, Tindak Pidana Korupsi Bantuan Sosial

 

Abstract: This study aims to determine the rules of criminal law for perpetrators of corruption in social assistance during the COVID-19 pandemic and determine the appropriate type of crime against perpetrators of corruption in social assistance during the COVID-19 pandemic. This research is a normative legal research, with a perspective using primary and secondary legal materials which are analyzed using deductive logic reasoning methods. The technique of collecting legal materials used is a literature study that is relevant to the topic of discussion in the research. The results of the study showed that the regulation of criminal acts of corruption in social assistance during the COVID-19 pandemic along with the threat of punishment has been regulated in several laws and regulations, such as the PTPK Law, UNCAC and the Money Laundering Law. The type of criminal act imposed for perpetrators of corruption must be able to provide a deterrent effect and return the assets that have been obtained by the perpetrators of corruption to the state. Corruption perpetrated by state officials against funds for the provision of social assistance during the COVID-19 pandemic should have been a consideration for the judges in imposing the maximum sentence.
Keywords: Criminal Law Rules, Types of Criminal, COVID-19 Pandemic, Corruption Crimes Social Assistance
ANALISIS TINDAK PIDANA KORUPSI YANG DILAKUKAN SECARA BERSAMA-SAMA OLEH ANGGOTA DPRD KOTA SURABAYA
Authors: Niken ' , Ginting Rehnalemken
Published: May 2023

Abstract: This article aims to find out, describe, and analyze the arrangements and considerations of judges in cases of corruption that were carried out jointly by members of the Surabaya City DPRD. This research uses doctrinal law research. This research is prescriptive or applied. The research approach used by the author is a case study approach and a conceptual approach. The legal materials used by the author are primary legal materials and secondary legal materials. The author's technique of collecting legal materials uses library research techniques and technical analysis of legal materials using the syllogistic deductive method. The decision of the Panel of Judges on the case of a criminal act of corruption that was carried out jointly by the Members of the Surabaya City DPRD has taken into account all aspects of the actions committed by the defendant on his position as a member of the Surabaya City DPRD for the 2014-2019 period and has fulfilled the juridical aspect, namely by referring to positive law in Indonesia.

Keywords:  Corruption Crimes; participation; Member of the Surabaya City DPRD

 

Abstrak: Artikel ini bertujuan untuk mengetahui, mendeskripsikan, dan menganalisa pengaturan serta pertimbangan Hakim pada kasus tindak pidana korupsi yang dilakukan secara bersama-sama oleh anggota DPRD Kota Surabaya. Penelitian ini menggunakan penelitian hukum doktrinal. Penelitian ini bersifat preskriptif atau terapan. Pendekatan penelitian yang digunakan oleh penulis adalah dengan pendekatan studi kasus (case study) dan pendekatan konseptual (conceptual approach). Bahan hukum yang digunakan penulis adalah bahan hukum primer dan bahan hukum sekunder. Teknik pengumpulan bahan hukum penulis menggunakan teknik studi kepustakaan dan teknis analisis bahan hukum menggunakan metode dedukatif silogisme. Putusan Majelis Hakim atas kasus tindak pidana korupsi yang dilakukan secara bersama-sama oleh Anggota DPRD Kota Surabaya telah memperhatikan segala aspek perbuatan yang dilakukan oleh terdakwa atas kedudukannya sebagai anggota DPRD Kota Surabaya Periode 2014- 2019 dan telah memenuhi aspek yuridis yaitu dengan mengacu kepada hukum positif di Indonesia.

Kata Kunci:  Tindak Pidana Korupsi; Penyertaan; Anggota DPRD Kota Surabaya
ANALISIS DASAR PERTIMBANGAN HUKUM HAKIM DALAM MENJATUHKAN SANKSI PIDANA TAMBAHAN KEBIRI KIMIA (STUDI PUTUSAN PENGADILAN NEGERI MOJOKERTO NOMOR: 69/PID.SUS/2019/PN.MJK.)
Authors: Fianni Sisma Annisa , Novianto Widodo Tresno
Published: May 2023

Abstrak
Penulisan Hukum ini dilatar belakangi oleh dijatuhkannya sanksi pidana tambahan kebiri kimia  terhadap pelaku kekerasan seksual pada anak dalam putusan Pengadilan Negeri Mojokerto Nomor: 69/Pid.Sus/2019/PN.MJK. Penelitian ini dilaksanakan guna mengetahui dasar hukum pertimbangan hakim dalam menjatuhkan putusan tersebut. Penelitian ini menggunakan metode penelitian normatif dengan pendekatan kasus dan perundang-undangan. Berdasarkan penulisan ini diketahui bahwa putusan tersebut memuat pasal yang tidak berkaitan dengan sanksi dan tindakan Terdakwa, serta sanksi pidana tambahan kebiri kimia tersebut belum dapat dilaksanakan. Oleh karena itu, Hakim perlu mempertimbangkan apakah putusannya tersebut dapat dieksekusi dan mencantumkan pasal yang berkaitan dengan sanksi tersebut dalam putusan. Selanjutnya, Pemerintah melalui Kementerian Hukum dan HAM, perlu mengatur ketentuan pelaksanaan kebiri kimia.
Kata Kunci : Dasar Hukum; Pertimbangan Hakim; Kebiri Kimia;

Abstract
This study is motivated by the imposition of additional chemical castration criminal sanctions against child  sexual violence perpetrators in the decision of the Mojokerto District Court Number: 69 / Pid.Sus / 2019 / PN.MJK. This research was conducted to find out the legal basis for judges’ consideration in dropping the decision. This study uses a normative research method with a case and legislation approach. Based on this paper, it is known that the decision contains articles that are not related to the defendant’s sanctions, and actions as well as additional chemical castration criminal penalties. Therefore, the Judge needs to consider whether the decision can be executed and include articles related to the sanction in the decision. Furthermore, the Government through the Ministry of Law and Human Rights needs to regulate the provisions of the implementation of chemical castration.
Keywords : Legal Basis; Judge’s Considerations; Chemical Castration;
KRITIK TEORI HUKUM FEMINIS TERHADAP KEBIJAKAN ABORSI PADA KORBAN PERKOSAAN DI INDONESIA
Authors: Savira Vivi , Novianto Widodo Tresno
Published: May 2023

Abstrak
Aborsi pada korban perkosaan dilegalkan menurut Undang-Undang Nomor 36 Tahun 2009 tentang  Kesehatan, tetapi pengaturan mengenai syarat-syarat aborsi tidak bisa dipenuhi atau setidaknya sulit dipenuhi oleh korban perkosaan. Penelitian ini bertujuan untuk menganalisis dan mengkritik kebijakan aborsi pada korban perkosaan, termasuk syarat-syarat aborsi yang tercantum dalam Undang-Undang Nomor 36 Tahun 2009 tentang Kesehatan dan Peraturan Pemerintah Nomor 61 Tahun 2014 tentang Kesehatan Reproduksi dengan menggunakan teori hukum feminis sebagai pisau analisis. Penelitian ini merupakan penelitian hukum normatif yang menggunakan pendekatan perundang-undangan dan konsep. Hasil penelitian dalam penelitian ini adalah kebijakan aborsi pada korban perkosaan masih belum berperspektif feminis dan menegasikan pengalaman perempuan serta menempatkan perempuan dalam ikatan ganda. Hal ini disebabkan oleh syarat batasan usia kehamilan aborsi pada korban perkosaan yang memandang perempuan adalah homogen dan tidak mempertimbangkan  pengalaman perempuan sebagai  suatu dasar perumusan kebijakan sehingga yang dihasilkan adalah  termarginalisasinya perempuan korban perkosaan dalam mengakses aborsi yang aman. Untuk  mengatasi masalah tersebut diperlukannya keterlibatan perempuan terdampak yaitu korban perkosaan dalam merumuskan kebijakan mengenai aborsi pada korban perkosaan.
Kata Kunci : Aborsi, Perkosaan, Teori Hukum Feminis

Abstract
Abortion resulting from rape is legal based on Health Act Number 36 of 2009, nonetheless there are  several conditions that can not be fulfilled or at least difficult to be fulfilled by rape victims. The aim of this study is to analyze and criticize the policies of abortion resulting from rape in Health Act Number 36 of 2009 and Government Regulation Number 61 of 2014 on Reproductive Health by using feminist legal theory. This research is a normative legal research that uses statutory approach and conceptual approach.  The results of this study shows that abortion resulting from rape negates women’s experience and places women in double-bind dilemma. This is due to the gestational age limit for abortion resulting from rape that view women as homogenous and do not consider women’s experience as a fundamental grounds of abortion policies, so as the result is marginalization of rape victims. To solve this problem, the involvement of affected women is needed, especially rape victims, in formulating policies on abortion resulting from rape.
Keywords : Abortion, Rape, Feminist Legal Theory
IMPLIKASI PEMAHAMAN WARGA MASYARAKAT TERHADAP MALPRAKTIK MEDIS DALAM KAITANNYA DENGAN CITA PENANGAN KORBAN MALPRAKTIK MEDIS YANG BERKEADILAN
Authors: Sulistyanta ' , Hartiwiningsih ' , Ginting Rehnalemken , Budyatmojo Winarno , Subekti ' , Setiyanto Budi , Pratiwi Dian Esti , Fitriono Riska andi
Published: May 2023

Abstrak

Kegiatannya memberikan pengetahuan dan pemahaman pada masyarakat agar mengetahui secara detail bahwa, setiap warga negara dilindungi hak-haknya oleh konstitusi. Hak untuk mempertahankan hidup dan kehidupannya dapat diartikan bahwa setiap orang mempunyai hak yang sama untuk mempertahankan hidupnya. Salah satunya adalah hal untuk mendapatkan pelayanan kesehatan. Pelayanan kesehatan dilakukan oleh tenaga kesehatan yang professional.

Berdasakan undang-undang No 36 tahun 2014 tentang Tenaga Kesehatan diatur mengenai hak dan kewajiban tenaga kesehatan, sedangkan dalam undang-undang No 44 tahun 2009 tentang Rumah Sakit terdapat hak dan kewajiban pasien. UU No 29 tahun 2004 tentang Praktek kedokteran yang menegaskan bahwa tenaga kesehatan dalam melakukan profesinya benar-benar dituntut perilaku profesionalnya.  

Apabila timbul kasus-kasus tindakan malpractice, diharapkan pola penyelesaian kasus tersebut agar lebih berkeadilan dan bermartabat perlu dilihat secara komprehensif. Sehingga tidak akan timbul putusan yang hanya memberikan keadilan kepada salah satu pihak sedangkan pada pihak lain (terutama korban) kurang mendapat perhatian. Suatu alternatif model penyelesian kasus malpraktik medis berdasarkan keseimbangan antara tugas professional dan korban (pasien) yang ada.

Tenaga medis tidak mungkin melakukan malpraktik dengan kesengajaan yang terjadi kemungkinan adanya kelalaian dalam melakukan pekerjaan profesinya sesuai standar operasional yang ada. Pada sisi yang lain kepercayanan yang begitu besar seorang pasien terhadap dokter perlu mendapatkan perhatian pula. Pendekatan penyelesaian telah dilakukan secara penegakan kode etik dan secara profesi, terdapat kekurangan dan kelebihannya, atas dasar pertimbangan ini maka dicarikan alternative penyelesaian terhadap terjadinya malpraktik di bidang medis yang dapat menghasilkan putusan yang seimbang dan berkeadilan. Suatu konstruksi penegakan hukum yang diharapkan dapat memberikan keadilan bagi semua pihak.

Sosialisasi tentang pola penyelesaian secara berkeadilan tersebut perlu di lakukan terhadap masyarakat agar para warga masyarakat sadar akan posisi dan kondisi yang terwujud dalam hak dan kewajibannya.  

Kata kunci: Malpraktik medis, korban, kesadaran hukum, berkeadilan
RETRACTED: Unveiling the Diagn: RCR and SPIO contrast-enhanced DWI MRI for Distinguishing Benign Liver from Malignant Liver Lesions
Authors: Mehar Muhammad Abdullah , Bhatti Sadaqat Ullah , John Akash , Ali Abid , Ahmad Aiman Aftab
Published: May 2023

The authors have requested that this preprint be removed from Research Square.
Summer precipitation and wildfire changes in Siberia induced by stratospheric ozone
Authors: Xie Fei , Xia Yan , Tian Wenshou , Chipperfield Martyn , Niu Yinli , Liu Na , Feng Wuhu , Han Yuanyuan , Gui Ke
Published: May 2023

Summer precipitation variations substantially impact food production and wildfire frequency in Siberia, exhibiting trends of decrease, increase, and subsequent decrease in recent decades. Nonetheless, the external factors contributing to these long-term precipitation patterns remain unclear. Our findings reveal a strong connection between stratospheric ozone changes and summer precipitation in Siberia, as evident in both observations and simulations. An increase in the lowermost stratospheric ozone results in the heating of the upper troposphere and lower stratosphere (UTLS) in mid-high latitudes during summer. This warming effect prompts divergence in the upper troposphere, accelerating polar circulation and subsequently promoting convergence and upwelling in the lower troposphere, favoring more precipitation. The 20% rise in stratospheric ozone between 1990 and 2010 may account for approximately 50% of the increase in precipitation in Siberia, while the post-2010 decline in ozone could be responsible for the heightened incidence of wildfires in recent years due to inhibit precipitation.
Study on the initiation mechanism and motion characteristics of the Daguangbao landslide and the slope stability evaluation method
Authors: Jing Pengxu , Zhang Xiangyu , Gong Wenjun , Ma Liqiu , Xu Yifan , Yang Haitao
Published: May 2023

The Daguangbao landslide was the largest landslide triggered by the 2008 Wenchuan Ms8.0 earthquake, and has become a research focus due to its large scale, unique genesis, and complex kinematic processes. In this paper, the original topographic conditions and actual earthquake levels are restored, and the initiation mechanism and motion characteristics of the Daguangbao landslide under seismic action is investigated firstly by the numerical simulation with the help of FLAC 3D. Then, the evaluation method of slope stability is established base on the comprehensive weight and tension methods. The specific conclusions are as follows: (1) The foot of the slope is formed by the rapid downward erosion of Huangdongzi Valley, where stress is relatively concentrated. Under the earthquake's action, displacement occurs first, and the rock mass is broken. (2) Under continuous seismic wave action, the slope gradually displaces from the bottom to the top and concentrates in the middle of the slope, resulting in vibration and fragmentation. (3) The rock layer between the broken rock mass and the downstream rock mass constantly relaxes, and friction resistance decreases, forming the main sliding surface. (4) The tension-shear action caused by the earthquake breaks the connection between the sliding body and the upstream, and the broken rock mass slides down the main sliding surface at high speed, retracting and accumulating under the mountain barrier, forming the debris flow accumulation area. (5) The isolated peaks of the Daguangbao were thrown out horizontally and landed in the debris accumulation area under the earthquake's action, exhibiting the phenomenon of "flying peaks". (6) The proposed evaluation method of slope stability has high accuracy and good prospects for engineering application. The research achievements of this paper can offer reference and guidance for research on landslides under the influence of earthquakes.
Sensing performance of lead monoxide (PbO) doped tin oxide thick film gas sensor
Authors: Vishwakarma Ankit Kumar , Sharma Ajaya Kumar , Mishra Ashok Kumar , Srivast Subodh , Sharma Nutan , Yadava Lallan
Published: May 2023

Gas sensors based on metal oxide nanostructures are in demand for the safety of human health and protection from environmental pollution. This type of sensors is more attractive in modern life for electronic devices because of low cast, more efficient, high reliability, fast response, more selective, and simplicity. In this paper we report undoped and PbO doped SnO2 thick film to study its microstructural and sensing behaviours. Three samples have been fabricated using screen printing technique on an alumina substrate and this is SnO2 (S1) and 1wt% PbO doped SnO2 (S2 and S3) at 800 0C and 900 0C. XRD and AFM techniques are used to observe the structural behaviours and it is found that the crystallite size decreases with PbO doping. The sensing properties such as sensing response, selectivity and transient time of the deposited thick films were studied at 200°C for various test gases such as ethanol, LPG and acetone concentrations (0–5000 ppm level). We also found that the response of sensor S3 to the test gas ethanol is ~ 3.38 times of LPG and ~ 1.95 times that of acetone. The response and recovery times of the ethanol gas for S3 sensor are 41s and 125s, respectively. Therefore, the deposited sensor S3 is a more suitable sensor for the test gas ethanol than LPG and acetone at 200 0C.
Protein cargo of Nef-containing exosomal extracellular vesicles may predict HIV-associated Neurocognitive Impairment status
Authors: Caobi Allen , Werne Rachel , Gomez Mario , Andre Mickensone , Lima-Hernandez Francisco , Nair Madhavan , Raymond Andrea Denise , Thomas Charo
Published: May 2023

Exosomal extracellular vesicles (xEVs) in plasma and cerebrospinal fluid (CSF) of aviremic people living with HIV/AIDS (PLWHA) contain the HIV Negative factor (Nef) protein. However, the role of xEVs and Nef-containing-xEVs(xEV-Nef) in HIV neuropathology is unknown. To determine whether the content of matched xEVs derived plasma or CSF correlated with the neurocognitive impairment (NCI) status of PLWHAs diagnosed with either asymptomatic neurocognitive impairment (ANI), mild neurocognitive disorder (MND), or HIV-associated dementia (HAD) a cross-sectional study was performed. The size and protein content of the xEVs characterized via dynamic light scattering (DLS) and LC-MS/MS, respectively. xEV size was not significantly different between ANI, MND, or HAD groups. CSF of PLWHAs with NCI contained significantly more xEVs than matched plasma. xEV-Nef CSF concentration was elevated in PLWHAs with NCI and correlated with CD4 T-cell count. Plasma-derived xEV protein profiles from PLWHAs with ANI or MND differed from PLWHAs without NCI. Over-representation analysis using Reactome and KEGG databases show proteins involved in pathways associated with heme scavenging, signaling(MAP kinase and integrin-alpha), Toll-like receptor regulation, clot formation, complement, and cytosolic calcium level were elevated in MND. Pathways upregulated within the ANI group involved high-density lipid (HDL) remodeling, post-translational protein phosphorylation, and platelet activation. Overall, the data shows that xEV protein profiles of ANI and MND differ, suggesting protein profiles of peripheral xEVs, xEV-Nef, and CD4 T-cell count may discern NCI status.
APC and ZBTB2 may mediate M2 macrophage infiltration to promote the development of renal fibrosis: Bioinformatics Analysis
Authors: Song Jianling , Ke Ben , Fang Xiangdong
Published: May 2023

Background and PurposeM2 macrophages are closely associated with renal fibrosis. The purpose of this study was to analyze the infiltration of M2 macrophages in uremic patients and to seek new strategies to slow down the progression of renal fibrosis.MethodsExpression data were queried in the GEO database for uremic samples. Control and uremic DEGs were identified. Immune cell infiltration was investigated by CIBERSORT and modules associated with M2 macrophage infiltration were identified by WGCNA. Consistent genes were identified using the LASSO and SVM-RFE methods to search for overlapping genes. ROC curves were examined for the diagnostic value of candidate genes. PT-PCR examined the expression levels of candidate genes obtained from uremic patients in M2 macrophage.Results1298 DEGs were found in the GSE37171 dataset. Significant enrichment of DEGs was observed in 20 BP, 19 CC, 6 MF and 70 KEGG pathways. CIBERSORT analysis observed a significant increase in B cell memory, dendritic cell activation, M0, M1, M2 and plasma cell numbers in uremic samples. We identified the 10 most interrelated genes. In particular, APC and ZBTB2 were adversely associated with the infiltration of M2 macrophages. Importantly, the expression levels of APC and ZBTB2 were far lower in M2 macrophages from uremic patients than in healthy individuals.ConclusionAPC and ZBTB2 may mediate M2 macrophage infiltration to promote the development of renal fibrosis.
WITHDRAWN: Paraneoplastic Prothrombotic State Causing Recurrent Ischemic Stroke ; a case report
Authors: Rivest Charles Eric , Rioux Bastien , Lanthier Sylvain , Gioia Laura C.
Published: May 2023

Background
This case report is a good example of when to suspect a paraneoplastic prothrombotic state (PPS) as a cause of ischemic stroke (IS). Many clinical, laboratory and imaging features linked to PPS are well illustrated in this patient.
Case presentation
A 78 years old patient, known for a single 2x1,5cm middle lobe lung nodule who was on apixaban 5mg BID for documented pulmonary embolisms in his latest hospitalization, was admitted to the stroke unit for left-sided hemianopia and hemineglect. Brain MRI showed multifocal acute and subacute infarcts involving the anterior and posterior cerebral arteries and the right cerebellum. The standard stroke work-up were unremarkable beside a mild normocytic anemia (122 g/L) and a high d-dimers level. The patient returned to the hospital, eleven days after discharge for new left MCA infarcts confirmed by head CT. At this point, D-dimers were still very high (>4,400 ng/ml), C-reactive protein was slightly increased (14 mg/L) and there was still a mild inflammatory anemia. Cancer work-up was started and confirmed a stage III lung adenocarcinoma.
Conclusion
In this stroke patient, an etiological diagnosis of PPS was supported by the presence of a lung nodule, negative standard neurovascular workup, stroke recurrence (despite anticoagulation), infarcts in multiple vascular territories, and markers of systemic inflammation (anemia, high CRP) and active fibrinolysis (high d-dimers). This etiology should be considered in IS patients presenting with those PPS markers.
TIMEWISE: Temporal Urban Dynamics for Urban Resilience - Lessons from the Global North and South
Authors: Krishnan Supriya , Aydin Nazli , Comes Tina
Published: May 2023

Accelerating climate change and climate-related emergencies require cities to improve resilience across multiple short- and long-lived systems. Urban systems have individual change dynamics that are highly interconnected. However, the aftermath of disruptions is often characterised by myopic decision-making that disregards the long-term implications across systems. In this study, we develop the theoretical foundation for temporal dynamics for urban resilience. (1) We briefly characterise and conceptualise the interplay of major temporal dynamics in urban planning, including endogenous lifecycles and exogenous drivers. (2) We empirically examine temporal dynamics through climate urbanism in regions representing the Global North (GN-Amsterdam, the Netherlands) and Global South (GS-Mumbai, India). Our findings reinforce the need to embed short-term planning goals within long-term resilience visions. To address the lack of systematic planning approaches incorporating temporalities, we present options for temporal planning processes that harmonise the lifecycles of urban systems, adapt to disruptions and align planning horizons toward resilience. We discuss the potential applications of both options in the Global North and South.
Transition for people with dementia from day respite services to permanent residential care: a realist synthesis
Authors: Meyer Claudia , Golenko Xanthe , Sinclair Ron , Lowthian Judy
Published: May 2023

Respite and permanent transition to residential aged care are processes that are designed to support preferences and needs of people living with dementia and their carers as the disease progresses. These services are highly variable in acceptability, accessibility, and availability for the caregiving dyad, often not reflecting a person-centred, co-ordinated and cohesive approach. This study aimed to use a two-phase realist synthesis to explore how respite and permanent transition models of care work in different contexts, through different mechanisms to produce varying outcomes. Phase 1 explored preliminary theories and assumptions of the respite care journey, including (a) identification of systematic reviews and innovative programs, and (b) semi-structured interviews sessions with key stakeholders. Phase 2 involved an iterative scoping review to identify and map the available evidence, with a synthesis designed to unpack underlying program theories of why, for whom and in what circumstances respite/transition models of care works. Phase 1(a) identified ten citations from 126 systematic review abstracts. Fourteen residential care managers participated in a contextual scan – Phase 1(b). Phase 2 expanded this knowledge, identifying a further 13 studies. Three program theories, at the macro, meso and micro level, were elucidated: (1) system-level evidence-based integration, through collaboration and co-ordination; (2) inclusive, quality care, with supportive environmental design; and (3) trust, autonomy, and meaning-making. A novel realist synthesis approach was used to explore respite and permanent transition models of care beyond ‘what works’. This approach expands our understanding beyond intervention ‘x’ working for (or not) population ‘y’, but rather that models of care operate in different contexts with different mechanisms to produce different outcomes. Importantly, findings at the macro, meso and micro level context, suggest nuance, with a shared decision-making approach, is needed to optimise the ever-changing dementia care journey.
Comparative analysis of the transcriptome and efficacy of bioactive Centella asiatica exosomes on skin cells
Authors: Kim Min-Ha , Yoon Eun Jeong , Kim Jung Soo , Park Si Jun , Lee Hyunsang
Published: May 2023

Studies on plant-derived natural products that have no side-effects have attracted great attention from the cosmetics industry. Plant-derived exosomes are nanovesicles (30–150 nm in size) that contain biomolecules, which protect plants from stress and pathogens. In this study, we determined the availability of physiologically active Centella asiatica (Cica) extract and Cica exosome for cosmetic use with human keratinocytes using an in vitro efficacy assay, transcriptome analysis, and miRNA profiling. In vitro efficacy analysis revealed that Cica extract and Cica exosome have regenerative and wrinkle-improving effects. Comparative transcriptome analysis between Cica exosome- and Cica extract-treated-human keratinocytes revealed 46% more gene expression in Cica exosome-treated cells than Cica extract-treated cells; moreover, the expression of marker genes involved in skin aging and regeneration was upregulated. miRNA analysis of Cica exosomes identified 11 novel miRNAs. Prediction of miRNA targets revealed that Cica exosomal miRNA can inhibit genes involved in melanin biosynthesis and dermatitis. Transcriptome analysis confirmed that the predicted human target genes were downregulated by Cica exosome miRNA compared with the control. Thus, Cica exosomes and Cica extracts can have a positive effect on skin regeneration, wrinkle improvement, and skin barrier improvement. Cica exosomal miRNA has potential whitening and anti-dermatitis effects.
Automated Classification of Big X-ray Diffraction Data Using Deep Learning Models
Authors: Abdolrahim Niaz , Salgado Jerardo , Lerman Samuel , Du Zhaotong , Xu Chenliang
Published: May 2023

Current in-situ X-ray diffraction (XRD) techniques generate data over human analytical capabilities – leading to the loss of novel insights. Automated techniques require human intervention, and lack the performance and adaptability needed for material exploration. With the critical need for high-throughput automated XRD pattern analysis of novel materials, we developed a generalized deep learning model to classify a diverse set of materials’ crystal systems and space groups. In our approach, we generated training data with a holistic representation of patterns that emerge from varying experimental conditions and crystal properties. We then used an expedited learning technique to refine our model’s expertise to experimental conditions. Additionally, we used evaluation data to interpret our model’s decision-making and optimized model architecture to elicit classification based on Bragg’s Law. We evaluated our models on experimental data, novel materials, and altered cubic crystals, where we observed state-of-the-art performance and even greater advances in space group classification.
Transcriptional Landscape and Heterogeneity of Adenine-induced vs 5/6 Nephrectomized Renal Fibrosis Rats
Authors: Zhang Lei , Dai Rong , Wang Dong , Cheng Meng , Sang Tian , Peng Chuyi , Jin Hua , Wang Yiping
Published: May 2023

Background The end point of renal injury induced by 5/6 nephrectomy and adenine is renal fibrosis, but the path of renal fibrosis is different. It is important to clarify the different paths of two types of renal injury from the single-cell level for the precise prevention and treatment of renal fibrosis.Methods The 10x Genomics platform was used for single-cell sequencing, including cell quality control, dimension reduction, and cluster analysis, GO, KEGG, and GSVA analysis of gene expression differences among cell clusters. Pseudotime analysis, regulatory analysis, and cell–cell interaction network analysis were used to analyze the differentiation of cell clusters, regulation of promoters, and differences in intercellular communication.Results Our study generated a single-cell transcriptional landscape and phenotypic heterogeneity of adenine-induced and 5/6 nephrectomized renal fibrosis. We also found the main differentially expressed genes of the cell subsets and the differences in intercellular communication between the two fibrosis models, which provided a new idea for accurate research and treatment of renal fibrosis in the future.Conclusion Our study has identifed differences in the major differentially expressed genes and intercellular communication between cell subpopulations in two models of adenine-induced and 5/6 nephrectomized renal fibrosis, they could become new targets for the treatment of renal fibrosis..
Synthesis, Structure and Magnetic Property of a New Cobalt (II) Complex Based on Pyridyl-substituted Imino Nitroxide Radical
Authors: Wang Xiaoling , Zhang Hongwu , Liu Daofu
Published: May 2023

A new cobalt(II)–radical complex: [Co(im4-py)2(PNB)2] (im4-py = 2-(4'-pyridyl)-4,4,5,5-tetramethylimidazole-1-oxyl, PNB = p-nitrobenzoic acid anion) has been synthesized and characterized by X-ray diffraction analysis, elemental analysis, IR and magnetic properties. X-ray analysis reveals that the complex crystallizes in monoclinic system, space group C2/c with a = 34.001(4), b = 6.3444(7), c = 24.615(3) Å, α = 90, β = 133.676(2), γ = 90°, V = 3840.4(8) Å3, Z = 8, Mr = 413.86, Dc = 1.432 g/cm3, μ = 0.516 mm-1, F(000) = 1724, the final GOF = 1.060, R = 0.0641 and wR = 0.1514 for 2660 observed reflections with I > 2σ(I). X-ray diffraction analysis shows that the complex is four coordinated with tetrahedron geometry, where the Co(II) ion is located in the central site of the tetrahedron, two radicals and two PNB ligands are trans-coordinated to the Co(II) ion. The magnetic susceptibility study indicates the complex exhibits weak ferromagnetic interactions between cobalt(II) and im4-py radical. The magnetic property is explained by the structure and a magnetic exchange mechanism.
The Thanks Classification, A New Method For Observing Paediatric Flexible Flatfoot
Authors: Zhu Junlang , Xie Jiewei
Published: May 2023

Background: Flatfoot shows the collapse or flattening of the medial longitudinal arch. 90% of emergency visits for foot pain in children are attributed to flatfoot. The diagnosis and classification of flexible flat feet in children is currently usually based on imaging or clinical measurements. Most of the existing classification methods of flexible flat feet in children are limited to single plane classification, without considering the influence of rotation and vision deformity. The aim of this research was to to summarize the classification of paediatric flexible flat foot and provide ideas for the treatment strategy of flat feet in children.
Method： foot appearance photos and footscan insole system test data of 126 children with flexible flat feet (252 feet) from May 2022 to October 2022 were collected. foot-scan insole system test were used to detect flatfoot and posterior foot heel valgus angle. Based on foot appearance photographs and foot-scan insole system tests. According to whether the foot arch is flat, whether the forefoot with abduction, whether the posterior foot is eversion, and other factors, the “Thanks” the classification of children's flat foot is described. Type A: footscan insole system test results showed flat foot, posterior foot heel valgus angle less than 5°, and without abduction of the forefoot; Type B: footscan insole system test results showed flat foot, combined with abduction of the forefoot, posterior foot heel valgus angle less than 5°; Type C: footscan insole system tests results showed flat foot, posterior foot heel valgus angle more than 5°, and without abduction of forefoot; Type D: footscan insole system tests results showed flat foot, posterior foot heel valgus angle than 5°, and combine with abduction of forefoot. Three experienced foot and ankle surgeons and three rehabilitation doctors independently observed the appearance photos and footscan insole systemtests data of 126 patients with flexible flat feet, determined the flat foot type according to the “Thanks” classification, and randomly reclassified after 4 weeks interval. Finally, 45 cases were randomly selected for internal validation (2 junior orthopedic surgeons), and the intraclass correlation efficient value was used to assess the reliability.
Result:The paediatric flexible flat feet were divided into 4 types according to the “Thanks” classification. The intraobserver and interobserver consistency of the Thanks classification was good (ICC 0.895 for foot and ankle surgeons, 0.918 for rehabilitation physicians; The first ICC of foot and ankle surgeons and rehabilitation doctors was 0.903, and the second ICC was 0.856. ICC of internal inspection is 0.873).
Conclsion:The “Thanks” the classification of paediatric flexible flat foot is easily learned and accepted by both surgical and non-surgical physicians. It has a good significance for evaluating the functionality of the paediatric flexible flat foot and guiding the selection of the treatment.