bluuebunny/crossref_metadata_2025 huggingface dataset:
Számokban a televíziózás átalakulása Magyarországon
Authors: Németh Marika
Published: December 2022

Az interneten megjelenő filmek, sorozatok és műsorok óriási kínálatbővülése elindította a televíziózás átrendeződését. A lineáris televíziózás mellett kialakult az interneten található mozgóképes tartalmak fogyasztása is, azaz az on-demand televíziózás. A folyamat jelentősége közismert, a mértéke azonban nem. A dolgozat az átalakulás jelen állapotát vizsgálja, számszerűsítve a lineáris televíziózásról leszakadó csoportokat és a hagyományos televíziózásnál maradó nézői csoportokat is. Az új helyzetben kialakult nézői csoportok közös jellemzője, hogy ragaszkodnak a televíziókészülék használatához és a közös televíziózás élményéhez, de egyre többen hajlandók aktív szerepet vállalni a műsorok megkeresésében (on-demand). Ez a tendencia vezet ahhoz, hogy egyre többen szakadnak el a magyar tartalmaktól és fordulnak a külföldi tartalmak (filmek, sorozatok, műsorok) felé.
Potret Konstitusionalisme Hukum Islam dalam Bingkai Ketatanegaraan Indonesia
Authors: Fauzani Muhammad Addi
Published: December 2022

Eksistensi hukum Islam dalam bingkai ketetanegaraan Indonesia secara normatif terlihat dalam rumusan Pancasila sebagai staatsfundamentalnorm dan penerapan negara hukum pancasila yang mengakomodir pelaksanaan nomokrasi Islam, terlebih pelaksanaan nomokrasi Islam secara umum telah dijamin dalam UUD 1945.Potret konstitusionalisme Hukum Islam ke depan dapat menerapkan hubungan antara kehadiran agama di ruang publik dengan demokrasi melalui konstruksi agama di ruang publik yang dinyatakan oleh Habermas. Konstruksi tersebut senada dengan pembagian hubungan agama dan negara dengan menyitir pandangan aliran simbiostik yang sebenarnya telah diterapkan dan memang pandangan yang paling tepat yang dapat dipertahankan oleh Indonesia.
PEMBERDAYAAN REMAJA ISLAM MASJID (RISMA) DALAM MEMBENTUK KUALITAS HIDUP ISLAMI RISMA DUSUN PUCANGANOM A
Authors: Amri Khairul , Hidayati Widiani , Nur Arifah Mir’atun
Published: December 2022

Remaja merupakan cikal bakal yang akan meneruskan kepemimpinan baik dalam skala masyarakat desa, hingga skala bangsa dan negara. Menimbang Urgensi Remaja yang cukup besar dalam kehidupan bermasyarakat, maka sudah seharusnya remaja mendapatkan perhatian dan bimbingan khusus dalam menjalankan perannya dengan baik. Islam memegang peranan penting dalam mengarahkan karakter dan menyelesaikan krisis karakter di kalangan remaja bahkan di seluruh peradaban manusia. Adapun dalam melakukan internalisasi nilai-nilai keislaman serta kepedulian remaja terhadap agama dibutuhkan wadah yang dapat menjadi media untuk melakukan kegiatan-kegiatan keislaman, Wadah dalam perhimpunan remaja islam biasa dikenal dengan sebutan RISMA yaitu Remaja Islam Masjid merupakan organisasi para remaja islam di setiap Dusun maupun Desa untuk melakukan kegiatan-kegiatan keagamaan. kegiatannya diantaranya mengajar TPA, Tadarus Alqur’an, dan Perayaan hari-hari besar islam dan lainnya. Dengan adanya RISMA, remaja dapat memiliki porsi untuk dapat menumbuhkan kepedulian pada keagamaan dan nilai-nilai islam didalamnya. Penelitian ini bertujuan untuk Memberikan kontribusi dalam upaya peningkatan kualitas hidup islami bagi remaja yang tergabung dalam organisasi Remaja Islam Masjid (RISMA) di Dusun Pucanganom A, Desa Pucanganom, Kecamatan Rongkop, Kabupaten Gunungkidul. Penelitian menggunakan metode Kualitatif, Data penelitian dikumpulkan dengan tiga metode (1) Observasi (2) Wawancara mendalam; (3) Dokumentasi. Keabsahan data dilakukan dengan triangulasi sumber, hasil penelitian ini adalah Pemberdayaan RISMA dalam membentuk kualitas hidup islami di Dusun Pucanganom A  dilakukan  dengan beberapa kegiatan yaitu Mengajar TPA (Taman Pendidikan Al-Quran), mengadakan Tadarus Al-Quran, mengadakan Perlombaan 17 Agustusan, Perlombaan Bulan Ramadhan dan perlombaan Masjid, dan membantu perayaan hari besar Islam seperti Maulid Nabi, Idul Adha dan Idul Fitri dan perayaan islam lainnya
The Effects of Ketogenic Diet on the Immune System: A Meta-Analysis
Authors: Tzenios Nikolaos , Tazanios Mary E. , Poh Omasyarifa Binti Jamal , Chahine Mohamed
Published: December 2022

Healthcare systems are mindful of the importance of proper diet and nutrition in reducing the risk of various chronic diseases resulting in hospitalizations. In this regard, they are focusing on promoting the intake of foods comprising various diets with health benefits, such as the ketogenic diet. In this meta-analysis, a total of 20 research studies on the effect of the ketogenic diet on the immune system were analyzed. The research studies were obtained from three databases: Google Scholar, PubMed, and Science Direct. From the meta-analysis, the odd ratio of a similar outcome of an improvement in the strength of immunity between the intervention and control group was 0.76. On the other hand, the p-value for the studies was 0.09, with 15 out of the 20 being considered statistically significant. The heterogeneity between the studies was I2 = 15%, signifying a low variability in the findings that is not by chance. The Ketogenic diet indeed has positive effects on immunity. Nonetheless, it can also result in negative effects that may harm human health.
Incorporation and Deposition of Spin Crossover Materials Into and Onto Electrospun Nanofibers
Authors: Kilic Maximilian Seydi , Brehme Jules , Pawlak Justus , Tran Kevin , Bauer Friedrich Wilhelm , Shiga Takuya , Suzuki Taisei , Nihei Masayuki , Sindelar Ralf , Renz Franz
Published: December 2022

We synthesized iron(II)-triazole spin crossover compounds of the type [Fe(atrz)3]X2 and incorporated and deposited them on electrospun polymer nanofibers. In view of possible applications, we chose iron(II)-triazole-complexes that are known to exhibit spin crossover close to ambient temperature. Therefore we used the complexes [Fe(atrz)3]Cl2 and [Fe(atrz)3](2ns)2 (2ns = 2Naphthalenesulfonate) and analyzed them with IR-, UV/Vis and Mossbauer spectroscopy and with a SQUID magnetometer. The synthesized complexes were then in one attempt deposited on fibers of polymethylmethacrylate (PMMA) and in another attempt incorporated into core-shell like PMMA fiber structures. This was done via two different electrospinning methods. Deposition was performed by uniaxial electrospinning and incorporation was performed by coaxial electrospinning. The obtained polymer-complex-composites were then further investitgated by the same methods as the pure complexes as well as by SEM pictures and EDX measurements. The analysis by UV/Vis spectroscopy, Mössbauer spectroscopy and temperature-depended magnetic measurements with the SQUID magnetometer showed that the spin crossover properties were maintained and were not changed after the electrospinning processes and that the complexes were not harmed during the procedure.
Integration of Epidemiological and Genomic Data to Investigate H5N1 HPAI Outbreaks in Northern Italy in 2021-2022
Authors: Fornasiero Diletta , Fusaro Alice , Zecchin Bianca , Mazzucato Matteo , Scolamacchia Francesca , Manca Grazia , Terregino Calogero , Dorotea Tiziano , Mulatti Paolo
Published: December 2022

Between October 2021 and April 2022, 317 outbreaks caused by highly pathogenic avian influen-za (HPAI) H5N1 viruses were notified in poultry farms in the northeastern Italian Regions. The complete genomes of 214 strains were used to estimate the genetic network based on the virus similarity. An exponential random graph model (ERGM) was used to assess the effect of at-risk contacts, same owners, in-bound/out-bound risk windows overlap, genetic differences, geograph-ic distances, same species and poultry company, on the probability of observing a link within the genetic network, which can be interpreted as the potential propagation of the epidemic via lateral spread or a common source of infection. The variables same poultry company (Est.=0.548, C.I.=[0.179;0.918]) and risk windows overlap (Est.=0.339, C.I.=[0.309;0.368]) were associated with a higher probability of link formation, while the genetic differences (Est.=-0.563, C.I.=[-0.640;-0.486]) and geographic distances (Est.=-0.058, C.I.=[-0.078;-0.038]) indicated a re-duced probability. The integration of epidemiological data with genomic analyses allows moni-toring the epidemic evolution and helps explain the dynamics of lateral spreads suggesting the potential diffusion routes. The 2021-2022 epidemic stresses the need to further strengthen the bi-osecurity measures, and to encourage the reorganisation of the poultry production sector to mini-mize the impact of future epidemics.
Small Sample Hyperspectral Image Classiﬁcation Based on the Random Patches Network and Recursive Filtering
Authors: Uchaev Denis , Uchaev Dmitry
Published: December 2022

In recent years, different deep learning frameworks were introduced for hyperspectral image (HSI) classification. However, the proposed network models have a higher model complexity and do not provide high classification accuracy if few-shot learning is used. This paper pre-sents an HSI classification method that combines random patches network (RPNet) and re-cursive filtering (RF) to obtain informative deep features. The proposed method first convolves image bands with random patches to extract multi-level deep RPNet features. Thereafter, the RPNet feature set is subjected to dimension reduction through principal component analysis (PCA) and the extracted components are filtered using the RF procedure. Finally, HSI spectral features and the obtained RPNet-RF features are combined to classify the HSI using a support vector machine (SVM) classifier. In order to test the performance of the proposed RPNet-RF method, some experiments were performed on three widely known datasets using a few training samples for each class and classification results were compared with those obtained by other advanced HSI classification methods adopted for small training samples. The comparison showed that the RPNet-RF classification is characterized by higher values of such evaluation metrics as overall accuracy and Kappa coefficient (https://github.com/UchaevD/RPNet-RF).
Defending The Defender: Detecting Adversarial Examples For Network Intrusion Detection Systems.
Authors: Khettaf Dalila , Bouzar-Benlabiod Lydia
Published: December 2022

The advancement in network security threats led to the development of new Intrusion Detection Systems(IDS) that rely on deep learning algorithms known as deep IDS. Along with other systems based on deep learning, deep IDS suffer from adversarial examples: malicious inputs aiming to change the prediction of a machine learning/deep learning model. Protecting deep learning against adversarial examples remains an open challenge. In this paper, we propose “NIDS-Defend” a framework to enhance the robustness of Network IDS against adversarial attacks. Our framework is composed of two layers: a statistical test and a classifier that together detect adversarial examples in real-time. The detection process consists of two steps: (1) flagging flows that contain adversarial examples with a statistical test, and (2) extracting individual adversarial examples in the previously flagged flows with a classifier. Our approach is evaluated on binary IDS with the NSL-KDD dataset. To generate adversarial examples, the crafting methods used are (1) Boundary attack and (2) HopSkipJumpAttack. We investigate the vulnerabilities of a Network IDS against adversarial examples, then apply our defense. The statistical test can confidently distinguish adversarial flows with more than 95% accuracy, and the classifier detects individual adversarial examples with more than 80% accuracy. We also show that our framework detects adversarial examples crafted by an adversary aware of the defense and confirm the effectiveness of our solution against adversarial attacks.
Modern Approaches for the Development of New Herbicides Based on Natural Compounds
Authors: Berestetskiy Alexander
Published: December 2022

Weeds are a permanent component of anthropogenic ecosystems, which requires strict control to avoid the accumulation of their long–lasting seeds in the soil. With high crop infestation, many elements of crop production technologies (fertilization, productive varieties, growth stimulators, etc.) turn out to be practically meaningless due to high yield losses. Intensive use of chemical herbicides (CH) has led to undesirable consequences: contamination of soil and wastewater, accumulation of their residues in the crop, the emergence of CH-resistant populations of weeds. In this regard, the development of environmentally friendly CH with new mechanisms of action is relevant. Natural phytotoxins of plant or microbial origin may be directly explored in herbicidal formulations (biorational CH) or indirectly as scaffolds for nature-derived CH. This review considers: 1) the main current trends in the development of CH that may be important for enhancement of biorational herbicides; 2) advances in the development and practical application of natural compounds for weed control; 3) the use of phytotoxins as prototypes of synthetic herbicides. Some modern approaches such as computational methods of virtual screening and design herbicidal molecules, development of modern formulations, determination of molecular targets are stressed as important to make exploration of natural compounds more effective.
New Framework for Assembly Digitalization and Traceability Using Smart Contracts and Bill of Assembly
Authors: Cohen Yuval , Rozenes Shai
Published: December 2022

The final assembly of appliances and automotive industries is a rigorous process, that has limited capabilities of full traceability associated with: (1) the parts installed, (2) their fabrication processes, and (3) the assembly work. This is also the case for each of its sub-assemblies The many parts and sub-assemblies that compose the final assembly, make full traceability a challenging fit, that is almost unsurmountable. Such full traceability along the entire supply-chain is not existent today and must be based on documentation of most assembled parts, assembly tasks, and inspection tasks that compose the full assembled product. In addition, security measures are needed to prevent hostile hacking and unauthorized approach to the assembly documentation throughout the entire supply chain. The related documentation and repeated verifications require considerable effort and have many chances for human errors. So, automating these processes has a great value. This article expounds a framework that harnesses block-chain and smart-contract technology to offer traceable and protected documentation of the assembly process. We expand the concept of a Bill-Of-Assembly (BOA) to incorporate data from the bill of materials (BOM), the associated assembly activities, the associated activities’ specification parameters and materials, and the associated assembly resources (machines and/or operators). The paper defines the operation of the BOA with blockchain and smart-contract technology, for attaining full traceability, safety, and security, for the entire assembled product. Future research could extend the proposed approach to facilitate the usage of the BOA data structure in constructing a digital twin of the entire simulated system.
Cellular and Humoral Immunity and Infection Responses to SARS-CoV-2:Immune Biomolecular Mechanisms by Case Study within SARS-CoV-2 Pathogenesis and Other Infections
Authors: Brown Brent
Published: December 2022

The coronavirus 2019 (COVID-19) pandemic was caused by a positive sense single-stranded RNA (ssRNA) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, other human coronaviruses (hCoVs) exist, of which Middle East Respiratory Syndrome (MERS) and SARS-CoV (SARS) showed higher mortality rates without causing a pandemic. As of December 2022, SARS-CoV-2 has resulted in over 6.6 million deaths worldwide through an array of acute to chronic pathologies. Historical pandemics include smallpox and influenza with efficacious therapeutics utilized to reduce overall disease burden. Therefore, immune system process analysis is required to compare innate and adaptive immune system interactions. Lymphatic system organs include bone marrow and thymus using a network of nodes throughout which white blood cells traverse glycolipid membranes utilizing cytokines and chemokine gradients that affect cell development, differentiation, proliferation, and migration processes as well as genetic factors affecting cell receptor expression. Innate processes involve antigen-presenting cells and B lymphocyte cellular responses to pathogens relevant to other viral and bacterial infections but also in oncogenic diseases. Such processes utilize cluster of differentiation (CD) marker expression, major histocompatibility complexes (MHC), pleiotropic interleukins (IL) and chemokines. The adaptive immune system consists of Natural Killer (NK) and T cells. Other viruses are also contributory to cancer including human papillomavirus (cervical carcinoma ), Epstein-Barr virus (EBV) ( lymphoma), hepatitis B and C (hepatocellular carcinoma) and human T cell leukemia virus-1 (adult T-cell leukemia). Bacterial infections also increase the risk of developing cancer( e.g. H. pylori). Therefore, as the above factors can cause both morbidity and mortality along-side being transmitted within clinical and community settings, it is appropriate to now examine advances in single cell sequencing, FACS analysis and many other laboratory techniques that allow insights into discoveries of newer cell types. These developments offer improved clarity and understanding that over-lap with known autoimmune conditions that could be affected by innate B cell or T cell responses to SARS-CoV-2 infection. Thus, this review quantifies and outlines the nature of specific receptors and proteins relevant to clinical laboratories and medical research by documenting both innate and adaptive immune system cells within current coronavirus immunology case study data and other pathologies to date.
Normative scores for CrossFit® Open Workouts: 2011 - 2022
Authors: Mangine Gerald T. , Grundlingh Nina , Feito Yuri
Published: December 2022

To create normative scores for all CrossFit® Open (CFO) workouts and compare male and female performances, official scores were collected from the official competition leaderboard for all competitors of the 2011-2022 CFO competitions. Percentiles were calculated in athletes (18 – 54 years) who completed all workouts within a single year ‘as prescribed’ and met minimum scoring thresholds. Independent t-tests revealed significant (p < 0.05) sex differences for 56 of 60 workouts. In workouts scored by repetitions completed, men completed more repetitions in 18 workouts by small-to-large differences (d = 0.22-0.81), whereas women completed more repetitions in 6 workouts by small-to-medium differences (d = 0.36-0.77). When workouts were scored by time-to-completion, men were faster in 10 workouts by small-to-large differences (d = 0.23-1.12), while women were faster in three workouts by small differences (d = 0.46). In three workouts scored by load lifted, men lifted more weight by large differences (d = 2.00-2.98). All other differences were either trivial or not significant. Despite adjusted programming for men and women, the persistence of performances differences across all CFO workouts suggest resultant challenges are not the same. These normative values may be useful to training and research in male and female CrossFit® athletes.
An Old Acquaintance. Could Adenovirus be our Next Pandemic Threat?
Authors: Saint-Pierre Gustavo Enrique , Conei Daniel , Lizama Luis , Vargas Daniela , Avendaño Luis Fidel , Ampuero Sandra
Published: December 2022

Human adenoviruses are one of the most important pathogens detected in acute respiratory diseases in pediatrics and immunocompromised patients. In 1953, Wallace Rowe described it for the first time in oropharyngeal lymphatic tissue. To date, more than 85 types of HAdV have been described, with different cellular tropisms. They can cause respiratory and gastrointestinal symptoms, even urinary tract inflammation, although most infections are asymptomatic. However, there is a population at risk that can develop serious and even lethal conditions. These viruses have a double-stranded DNA genome, 25-48 kbp, 90 nm in diameter, without a mantle, stable in the environment, and resistant to fat-soluble detergents. Currently the diagnosis is made with lateral flow immunochromatography or molecular biology through a polymerase chain reaction. The objective of this review is to recognize the variability of HAdV, the pandemic potential that a recombinant could present between HAdV-3 and 7 viral types, known to produce aggressive outbreaks in health facilities. The review determined the characteristics of HAdV, from the infection to treatment, vaccine development and the evaluation of the social determinants of health associated with HAdV, guiding the necessary measures for future sanitary control, and preventing disasters such as the SARS-CoV-2 pandemic.
On the existence of Steinhaus points. Elementary analysis
Authors: Kellin Nicholai Sergeevich
Published: December 2022

The paper discusses issues related to the well-known "square" Steinghaus hypothesis, which has already hit the list of Richard Guy's unsolved problems three times. Consideration is carried out exclusively by elementary methods. That is, only those that could be used in working with schoolchildren on mathematical projects of the International Computer Schools for the Young (ICSS - 4–7, 13–15). The particular results obtained are very extensive: both in the winter and summer sessions of the ICJJ, the task was to obtain the most general (using elementary methods) results with minimal assumptions: we study a system of four Pythagorean equations with seven unknowns. The numbering of formulas and lemmas is by paragraphs; the numbering of picturies and theorems is through. The designations of the variables in the main text are consistent with those used in Appendix 1 and the drawings cited therein. Variable notations and drawings in Appendices 2 and 3 follow Steinhaus's book Tasks and Thoughts.
ANTI-FUNGAL ACTIVITY OF ACALYPHA WILKESIANA: A PRELIMINARY STUDY OF FUNGAL ISOLATES OF CLINICAL SIGNIFICANCE
Authors: KATIBI Oludolapo Sherifat , ABOH Mercy Itohan , SALAWU Oluwakayinsola Adeola , KOLA-MUSTAPHA Adeola , OLATUNJI Lawrence Aderemi
Published: December 2022

Background: Acalypha wilkesiana (AW), a popular medicinal plant has been used in traditional medicine to treat a variety of skin disorders including pityriasis versicolor and seborrheic dermatitis. As a prelude to clinical trials in humans, an experimental study was carried out to determine the spectrum of antifungal activity of 2 variants of the Acalypha wilkesiana plant. Materials and Methods: The ethanol extract and herbal cream formulation of the dried leaves of 2 cultivars (Macrophylla & Hoffmani) of Acalypha wilkesiana were investigated for in-vitro antifungal activity by disc diffusion and micro-broth dilution techniques. Organisms tested were typed cultures of Malassezia furfur, Candida albicans and Trichophyton rubrum; and clinical strains of Microsporum canis and Epidermophyton floccosum. Results: Both cultivars (Macrophylla and Hoffmanii) of the plant showed good activity against all the fungi tested except Microsporum canis (8.0±0.00; 7.00±0.00 mm). The greatest activity was observed against Trichophyton rubrum (22.0±0.00; 24.00±0.00 mm). The Minimum Inhibitory Concentration (MIC) of the crude extract ranged between 0.25 and 8 mg/ml for all organisms, while that of the herbal cream was 0.31-8mg/ml. The lowest MIC was seen with Candida albicans for both varieties of the plant. The Acalypha wilkesiana Hoffmanii demonstrated a greater activity against Candida albicans and Malassezia furufur than the A. wilkesiana Macrophylla. Conclusion: This study reveals Acalypha wilkesiana leaf extract has potential for development as a cream that can be used to treat superficial fungal skin infections.
Determinants of Internal Auditor’s Ability in Detecting Fraud with Supervision as Moderating Variable
Authors: Septian Defel , Febrianti Widia
Published: December 2022

This study examines the effect of independence, time pressure, and workload on the ability of the Central Java Inspectorate auditor to detect fraud with supervision as a moderating variable. This study used 31 internal auditors of the Central Java Inspectorate Apparatus as the sample, determined based on census sampling. This study’s results indicate a positive influence between independence and the ability of auditors to detect fraud. Variables time pressure and workload suggest that there is a negative influence on the capability of auditors to detect fraud. The interaction between supervision with independence cannotstrengthen the ability of auditors to detect fraud. Interaction of supervision with time pressure and workload cannot weaken the ability of auditors to detect fraud. The government must recruit more Inspectorate Apparatuses in Central Java to mitigate time pressure and workload, so the auditor can detect fraud better.
The Effect of Financial Ratios on Financial Distress in Matahari Department Store Companies listed on the Indonesia Stock Exchange for the 2016-2020 period
Authors: Sari Permita Dwi Indah , Amaniyah Evaliati
Published: December 2022

The purpose of this study was to determine the ef ect of liquidity, leverage, profitability and activity on financial distress at Matahari Department Store companies listed on the Indonesia Stock Exchange (IDX) for the 2016-2020 period. This research was conducted descriptively and quantitatively. This research was processed using SPSS IBM 25. This research was conducted by analyzing financial statements, based on the application using the Z-score method. Descriptive data analysis techniques, classical assumption test, multiple linear regression analysis, and hypothesis testing. The results of this study are partially liquidity and leverage ratios have a negative and insignificant ef ect on financial distress, profitability ratios have a positive and insignificant ef ect on financial distress, while the activity ratio has a positive and significant ef ect on financial distress
Pengaruh Media Sosial Instagram dan Electronic Word of Mouth Terhadap Minat Berkunjung Objek Wisata Setigi Gresik
Authors: Nasyifa Nasyifa , Suyono Suyono
Published: December 2022

Research based on the lack of content provision and the provision of extensive information on social media is the main reason between the onslaught of competition and the use of social media that can be used to increase interest in visiting Setigi tourism objects. The aim was to determine the level of interest in visiting Setigi tourism objects based on the results of using and obtaining information from the social media Instagram and the presence of electronic word of mouth. The variables in this study is social media Instagram and electronic word of mouth variables, which became independent variables, while the dependent variable was interest in visiting Setigi Gresik tourism objects. This study uses a quantitative approach method using SPSS statistical calculations with a total of 99 respondentsThe results that have been found based on the existing problems are that there is a significant influence between Instagram social media variables on visiting interest, the electronic word of mouth variable has also had a significant influence. significant to the interest in visiting, as well as the simultaneous influence of the independent variables on the dependent variable.
Pengaruh Motivasi Kerja Terhadap Kinerja Karyawan Melalui Perilaku Kreatif Pemimpin Sebagai Variabel Intervening (Studi Pada Karyawan KSPPS BMT NU Jawa Timur Di Kec. Gapura Kabupaten Sumenep)
Authors: Aulia Nabila , Anshori M. Isa
Published: December 2022

This study has an objective to determine the effect of motivation on employee performance through creative behavior of leader as an intervening variable on employees of KSPPS BMT NU East Java, Gapura Sub District. In this study, the writer uses a probability sampling method that is a sampling to provide equal opportunities for each member of the population to be selected as a member of the sample, with a simple random sampling technique by taking samples from members of the population and doing it randomly with a consideration of at least 1 year of work with a population of 219 and a sample of 141 respondents. The methods used are questionnaires and interviews. The results of the study show that there is a partial effect of motivation and creative behavior of leader on employee performance and there is an effect of motivation on employee performance through creative behavior of leader as an intervening variable. The implication is that the main director as a leader in KSPPS BMT NU East Java can maintain and increase the motivation of the employee in order to improve employee performance.
Peran Keadilan Organisasi dalam Membangun Komitmen Organisasi untuk Meningkatkan Kinerja Karyawan
Authors: Dina Ela , Safrizal Helmi Buyung Aulia
Published: December 2022

This study discusses the commitment and performance of skiving employees at PT Karyamitra Budisentosa in the midst of organizational justice problems. This study is used to examine more deeply about the role of organizational justice in building organizational commitment to improve employee performance. This study uses qualitative research method to dig up information on the problems experienced by subjects of the study, namely organizational justice, organizational commitment, and employee performance. The writer uses 7 people as informants for different positions. Technique of collecting data uses the method of observation, method of interview, and method of documentation. The data validity test uses a credibility test using several techniques, namely persistence of observation, triangulation, reference materials, and member check. Technique of analyzing data consists of several processes, starting from data collection, data reduction, data presentation, to verification or drawing conclusions. The results of the study show that the role of organizational justice in building organizational commitment is through perception and trust in PT Karyamitra Budisentosa. When organizational commitment has been built on employees, then in the process of improving performance, this commitment plays a role in creating a sense of responsibility. Based on the results of the study, the writer provides suggestions for PT Karyamitra Budisentosa to take quick and appropriate action in creating organizational justice, because of the important role of organizational justice in the company.
ANÁLISIS DE LOS SITIOS WEB DE LAS CASAS MUSEO EN EL CONTEXTO DEL MARKETING LITERARIO
Authors: Parra José Francisco , Irlés Laura
Published: December 2022

En este estudio se analiza el turismo literario como tipo de turismo cultural, identificando las motivaciones del visitante y los principales tipos de recursos turísticos que lleva asociado. Las casas museo ofrecen a los visitantes una experiencia diferenciada de la que pueden experimentar en otros museos, constituyendo uno de los recursos de turismo literario más importantes no solo en España sino también en el resto de países iberoamericanos. En este estudio realizamos una adaptación del modelo eMICA para analizar el grado de madurez de los sitios web de una muestra de casas museo de escritores iberoamericanos. Los resultados muestran que, en general, existe un amplio margen de mejora para implementar funciones y herramientas que expriman todo su potencial desde el punto de vista de marketing, especialmente en lo que se refiere la interacción con los visitantes y la comercialización de sus servicios a través de la Web.
ACUERDOS CONCLUSIVOS Y SU RELACIÓN CON LOS DERECHOS HUMANOS SEGÚN LAS CONVENCIONES INTERNACIONALES SUSCRITAS POR MÉXICO EN MATERIA DEL DERECHO TRIBUTARIO
Authors: Ovando Arias Mateo , Islas Colín Alfredo , Piña Gutiérrez Jesús Antonio
Published: December 2022

Está siendo una tradición que los MASC sean aplicados en los conflictos que competen al derecho tributario, aunque en México persiste la resistencia para que sean aplicados como alternativa para la solución de conflictos, los países desarrollados como Italia, España, Francia, Estado Unidos, Inglaterra, entre otros, complementan las jurisprudencias del derecho tributario con los tratados internacionales de los derechos humanos para la solución pacífica mediante la asesoría en el ejercicio de los acuerdo conclusivos. Por eso esta investigación tiene como objetivo analizar si los acuerdos conclusivos cumplen con los requerimientos internacionales sobre los derechos humanos por medio de un estudio documental con un enfoque exploratorio-deductivo complementándolo con el método fenomenológico-analítico por medio de la revisión de la información formal o dogmático de primer y segundo nivel del sistema de convencionalidad y la obligatoriedad del derecho tributario. El acceso a la justicia está asegurado por el artículo 17 constitucional en la CPEUM, considerándolo como un derecho fundamental por medio control difuso de constitucionalidad en el ejercicio de los órganos competente de Estado. Finalmente, los acuerdos conclusivos garantizan la correspondencia tributaria del Estado y el ciudadano, vista desde el derecho humano, entra en juego lo fundamental del respeto y la defensa de la propiedad de las personas en el goce de su dignidad. Y esta visión se trasforma en colocar a la sociedad en primer plano y luego su conformación jurídica-económica en la figura del Estado.
Epidemiology, antifungal susceptibility, risk factors, and mortality of persistent candidemia in adult patients in China: A multicenter retrospective study
Authors: Li Yanping , Gu Chenghong , Yang Yuling , Ding Yinhuan , Ye Caihong , Tang Min , Liu Jinbo , Zeng Zhangrui
Published: December 2022

Background: Data on persistent candidemia (PC), a recognized complication of candidemia, are lacking in China. This study aimed to investigate the clinical characteristics and risk factors for the mortality of PC among adults in China.
Methods: This 6-year retrospective study analyzed the prevalence, species distribution, antifungal susceptibility, risk factors, and patient mortality of PC among adults in three regional tertiary teaching hospitals in China from 2016 to 2021. PC was defined as the isolation of the same Candida species from positive blood culture for ≥5 days following the initiation of antifungal therapy.
Results: The definition of PC was fulfilled by 36 patients (13.7%, 36/263). The mean age of the patients was 59.9 years (60 years for patients with PC; 59.8 years for those with non-PC; P > 0.05), and 131 (60.1%) were men [16 with PC (44.4%), 115 with non-PC (63.2%), P < 0.05]. The mean annual incidence was 0.15/1000 admissions (including PC 0.03/1000 admissions vs non-PC 0.12/1000 admissions, P < 0.05). Candida parapsilosis(14/36, 38.9%) and Candida albicans (81/182, 44.5%) were the predominant pathogens in patients with PC and non-PC, respectively. Most isolates were susceptible to flucytosine (99.0%) and amphotericin B (99.5%), and the activity of antifungal agents against Candida species was not statistically significantly different between patients with PC and non-PC (P> 0.05). The 30-day mortality rate was 20.2% (16.7% with PC vs 20.9% with non-PC, P > 0.05). Multivariable regression analysis showed that use of broad-spectrum antibiotics, and fluconazole were independent predictors of PC, sex (male) was the protective factor for PC. Respiratory dysfunction and length of hospital stay were independent predictors of 30-day mortality in patients with non-PC. C. tropicalis bloodstream infection (odds ratio, 12.642; 95% confidence interval, 1.059–150.951; P = 0.045) was an independent predictor of 30-day mortality in patients with PC.
Conclusions: The epidemiological data of patients with PC and non-PC were different in the distribution of Candida species, the mean annual incidence, and independent predictors of 30-day mortality. Flucytosine and amphotericin B could be used as first-choice drugs in the presence of PC infections.
Cadmium accumulation in peanut kernels: effect of location and genotype and its relationship with other factors
Authors: Yang Zhen , Gao Wei Wei , Jiang Chun Jiao , Liang Feng Jian , Wang Zhi Wei , Wang Xiu Zhen , Sun Xiu Shan , Zhang Ming Jun , Wang Chuan Tang
Published: December 2022

Seventy peanut cultivars were planted at two locations to study peanut kernel Cd accumulation. Six entries (8.57%) had a maximum kernel Cd concentration exceeding the European Union allowable upper limit of 0.20 mg/kg. Ten low Cd peanut entries with a maximum kernel Cd concentration below 0.10 mg/kg were tentatively obtained. Location, genotype and their interaction significantly affected peanut kernel Cd accumulation, with location contributing most of the variability (96.67%) and cultivar alone only accounting for 1.69%. Significant positive correlation was detected between kernel protein content and kernel Cd concentration. Negative and positive Spearman rank correlation was also found for SPAD readings and leaf spot ratings with kernel Cd concentration, respectively. The output of this study provides a basis for exploring the mechanisms underlying low Cd accumulation in peanut kernels and for mining relevant genes/QTLs through association analysis.
Bidirectional Meta-Kronecker Factored Optimizer and Housdorff Distance Loss for Few-shot Medical Image Segmentation
Authors: Kim Yeongjoon , Kang Donggoo , Mok Yeongheon , Kwon Sunkyu , Paik Joonki
Published: December 2022

To increase the accuracy of medical image analysis using supervised learning-based AI technology, a large amount of accurately labeled training data is required.
However, the supervised learning approach may not be applicable to real-world medical imaging due to the lack of labeled data, privacy of patients and the cost of expertise.
To handle these issues, we present a bidirectional meta-Kronecker factored optimizer (BM-KFO) framework for fast semantic segmentation of MRI images using only a few images.
To increase computational efficiency and a stable learning process, we adopted Kronecker-factored decomposition in the parameter optimization process with a model-agnostic meta-learning (MAML) framework.
The proposed framework is compatible with any model without network component modification, and learns the learning process and meta-initial points while training the unseen data.
We also used average Hausdorff distance loss (AHD-Loss) as our objective function with cross-entropy loss to focus on the morphology of lesions or organs in medical images.
Based on experiments, we demonstrate that BM-KFO with AHD-Loss can be used for general applications of medical image segmentation, and it outperforms the baseline method in a few-shot learning tasks.
A potential alternative systemic treatment option for epithelioid sarcoma
Authors: Xie Lu , Xu Jie , Liang Xin , Liu Kuisheng , Sun Xin , Sun Kunkun , Yang Rongli , Tang Xiaodong , Guo Wei
Published: December 2022

Background: Epithelioid sarcoma is a rare soft tissue sarcoma characterized by SMARCB1/INI1 deficiency. Much attention has been paid to the selective EZH2 inhibitor tazemetostat, where other systemic treatments are generally ignored. To explore alternative treatment options, we studied the effects of irinotecan-based chemotherapy in a series of epithelioid sarcoma patients.
Methods: We retrospectively reviewed data from patients with metastatic or unresectable epithelioid sarcoma at the Peking University People’s Hospital treated with irinotecan (50 mg/m2/d d1-5 Q3W) in combination with Anlotinib (12 mg Qd, 2 weeks on and 1 week off) from July 2015 to November 2021.
Results: A total of 54 courses were administered. With a median follow up of 21.2 months (95% CI, 12.2, 68.1), the 5-year overall survival rate was 83.3%. Five of eight (62.5%) patients presented with unresectable localized lesions, including local tumor thrombosis and lymphatic metastasis. The other patients had unresectable pulmonary metastases. Six of eight (75%) patients had progressed following two lines of systemic therapy. The objective response rate reached 37.5% (three of eight patients) while stabilized disease was observed in 62.5% (five of eight) of patients. No patient had progressed at initial evaluation. At the last follow up, two patients were still using the combination and three patients had ceased the therapy due to toxicities such as diarrhea, nausea, and emesis. One patient changed to tazemetostat for maintenance and one patient stopped treatment due to coronavirus disease 2019 (COVID-19). Another patient stopped therapy as residual lesions had been radiated.
Conclusions: The combination of irinotecan and Anlotinib as a salvage regimen may be considered another effective treatment option for refractory epithelioid sarcoma.
Trial registration: This trial was approved in the Medical Ethics Committee of Peking University People’s Hospital on October 28, 2022 (No.: 2022PHD015-002). The trial was registered in Clinicaltrials.gov with identifier no. NCT05656222.
Complexity Review of NIMBY conflict: Characteristics, Mechanism and Evolution Simulation
Authors: Luxin Cui , Yu Chen , Xing Wang , ShiYu Liu
Published: December 2022

Complexity is an essential characteristic of NIMBY systems, and few studies have analyzed NIMBY conflicts using the theory of complex adaptive systems. From the perspective of complexity, this study re-examines the characteristics and evolution mechanism of NIMBY conflicts and draws the following conclusions: (1) NIMBY conflicts are a complex system of interaction between multiple subjects and the environment, characterized by aggregation, Linearity, dynamics, flow characteristics, and hierarchy. (2) Build a stimulus-response model for the evolution mechanism of NIMBY conflicts based on the theory of complex adaptive systems and consider that adaptability is the driving force for the evolution of NIMBY conflicts. The effector promotes NIMBY subjects to gradually adapt to changes in the external environment and maximize their interests. (3) Using Agent simulation technology to simulate the evolution mechanism of NIMBY conflicts, we found that how the government responds to conflicts is more important than the intervention time; Residents' communication efficiency and connection probability will affect residents' behavior choices； The lower the residents' communication efficiency, the less likely it is to form NIMBY conflicts， and stronger resident relations can accelerate residents' convergence to the exit state, affecting the evolution of NIMBY conflicts. This study deepens the understanding of NIMBY conflicts and provides a new reference perspective for the governance of NIMBY conflicts.
In vivo CRISPR screens reveal SCAF1 and USP15 as novel drivers of pancreatic cancer
Authors: Martinez Sebastian , Geuenich Michael , Malik Ahmad , Weber Ramona , Woo Tristan , Jang Gun-Ho , Derovic Dzana , Al-Zahrani Khalid , Tsai Ricky , Fodil Nassima , Gros Philippe , Gallinger Steven , Neely G. , Notta Fayiaz , Sendoel Ataman , Campbell Kieran , Schramek Daniel
Published: December 2022

Functionally characterizing the genetic alterations that drive pancreatic cancer is a prerequisite for precision medicine. Here, we performed somatic CRISPR/Cas9 mutagenesis screens to assess the transforming potential of 125 recurrently mutated pancreatic cancer genes, which revealed USP15 and SCAF1 as novel pancreatic tumor suppressors. Mechanistically, we found that USP15 functions in a haplo-insufficient manner and that loss of USP15 or SCAF1 leads to reduced inflammatory TNFα, TGF-β and IL6 responses and increased sensitivity to PARP inhibition and Gemcitabine. Furthermore, we found that loss of SCAF1 led to the formation of a truncated, inactive USP15 isoform at the expense of full-length USP15, functionally coupling SCAF1 and USP15. Notably, USP15 and SCAF1 alterations are observed in 31% of pancreatic cancer patients. Our results highlight the utility of in vivo CRISPR screens to integrate human cancer genomics and mouse modeling for the discovery of novel cancer driver genes with potential prognostic and therapeutic implications.
Dissolution of a commercial regenerated cellulosic fibre (Cordenka) in the ionic liquid 1-ethyl-3-methylimidazolium acetate studied using time-temperature superposition
Authors: Alanazi Maer , Ries Michael E. , Hine Peter J.
Published: December 2022

Wide-angle X-ray diffraction (WAXS) and mechanical testing techniques are used to track the dissolution of a regenerated commercial cellulose fibre (Cordenka) in the ionic liquid 1-ethyl-3-methyl-imidazolium acetate [C2mim]+ [OAc]− for different times and temperatures. In the dissolution process, the oriented cellulose II crystals in the regenerated cellulose fibres dissolve and then reform into randomly oriented crystals to form a matrix phase, and this change in orientation enables us to follow the dissolution process using WAXS, and hence determine the dissolved matrix volume fraction vm. The change in the average molecular orientation P2 determined from an azimuthal (α) X-ray scan, allows the growth of the matrix volume fraction vm to be calculated with time and temperature. The growth of vm was found to follow time temperature superposition, with an Arrhenius behaviour, giving a value for the activation energy of Ea= 149 ± 4 kJ/mol. Young’s modulus was measured on all the resulting composite fibres. The fall of Young’s modulus with dissolution time and temperature was also found to follow time-temperature superposition, with an Arrhenius behaviour giving a value for Ea= 198 ± 29 kJ/mol. The Young’s Modulus results plotted against vm determined from the WAXS measurements fitted well to the Voigt upper bound parallel Rule of Mixtures.
Missed Nursing Care And Associated Factors Among Nurses At University Of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia, 2022. A cross sectional study
Authors: Kassie Huluager , Endalkachew Kidist , Kassahun Chanyalew Worku
Published: December 2022

Introduction: The lack of nursing care is the most common cause of quality problems in health care that results in adverse outcomes for patients, nurses, and organizations. Although there is a lot of evidence regarding nursing care practices, there is limited evidence about missed nursing care and its factors in Ethiopia and no evidence at all in the study area. Therefore, this study was designed to assess missed nursing care and related factors among nurses.
Methods: An institutional-based cross-sectional study was conducted among 485 nurses at the University of Gondar Comprehensive Specialized Hospital from May 15 to June 15, 2022. The data were collected through a self-reported questionnaire. A simple random sampling technique was used to select study participants. The data was then added to EPI DATA version 4.6 and exported to SPSS version 23 for analysis. Descriptive statistics were computed, and a summative score of missed nursing care was calculated. Then, multiple linear regression analysis was used to identify the factors of missed nursing care. A P-value of 0.05 was used to identify significant factors.
Results: In this study, missed nursing care was 62.5% (95% CI 60.98-64.02). Documentation of all necessary data, assessment of vital signs, intravenous care, and assessment as per hospital policy and patient education were the most frequently lacking nursing care. Being single in marital status (B=-4.609, P =0.004), adequacy of nursing staff (B=-2.458, P=0.003), satisfaction with income (B=-8.753, P=0.007), working in the medical unit (B=-5.708, P=0.002) and working in both day and night shift (B=1.731, P=0.027) were statistically associated with missed nursing care.
Conclusion recommendation: In this study, more than half of the participants missed basic nursing care. Efforts should be considered to enhance communication between health team members, assign a manageable number of patients per nurse, and adjust shifts and units.