bluuebunny/crossref_metadata_2025 huggingface dataset:
Carbon nanoparticles for identification of metastatic lymph nodes around the superior mesenteric artery in transverse colon cancer
Authors: Xu YuXin , Chi Pan , Huang Ying , Wang XiaoJie , Ye DaoXiong
Published: March 2020

Background Accurate identification of metastatic lymph nodes around the superior mesenteric artery (SMA), with or without metastasis, is vital for surgeons when dissecting lymph nodes in patients with transverse colon cancer. In the current study, we evaluated the prospect of using carbon nanoparticles in identification of lymph nodes around SMA. Methods We recruited a total of 220 patients, with transverse colon cancer, and divided them into two groups. The first group (n=51) was carbon nanoparticle (CN) while the other (n=169) had no carbon nanoparticle (NCN) group. Intraoperative and post-operative data were compared between the groups. Results We found that 117 patients were negative for D1 lymph nodes, while 3.4% were positive for D2 lymph nodes. Additionally, 169 patients were negative for D2 lymph nodes while 10.7% of patients were positive for D3 lymph nodes. Laparoscopy easily identified black-dyed lymph nodes in the CN group. Significantly higher numbers of positive station D3 lymph nodes (0.63 ± 2.43 vs 0.29 ± 1.03, p = 0.006), number of positive station 214 nodes (0.10 ± 0.13 vs 0.08 ± 0.17, p = 0.004), the number of positive lymph nodes (2.69 ± 5.38 vs 1.90 ± 4.22, p = 0.037), and the number of total lymph nodes (39.67 ± 19.33 vs 34.50 ± 18.99, p = 0.037) were found in the CN compared to NCN group. However, we found no significant differences between CN and NCN groups with regards to the number of positive station D1 and D2 lymph nodes. Conclusions We successfully identified metastases 214 LNs around SMA in transverse colon cancer using carbon nanoparticles. These particles have potential to significantly increase the number of positive and negative lymph nodes.
Deltex1 promotes cell proliferation and invasion and associated with clinical characteristics of breast cancer
Authors: Liu Xiaoyi , Hu Jianxia , Che Kui , Chi Jingwei , Fu Zhengju , Liu Xiangping , wang haibo
Published: March 2020

Background Deltex1 (DTX1) was found to play its role in the development of several kinds of cancer. The association between DTX1 and breast cancer was unclear. We aimed to investigate the association between DTX1 expression and clinical characteristics of breast cancer, further explore the possible mechanisms of DTX1 on the development of breast cancer. Methods We determined level of DTX1 expression by qRT-PCR, analyzed association between DTX1 and clinical characteristics of breast cancer by student’s test and ANOVA test. The possible mechanisms of DTX1 on the development of breast cancer were explored with breast cancer cell lines in vitro. Results Levels of DTX1 in breast cancer tissues were lower compared to FCD tissues and peri-neoplastic breast tissues (P<0.01). Lower expression of DTX1 was associated with advanced tumor grade (grade III, P=0.002), advanced clinical TNM stage (III-IV stage, P=0.017), positive lymph node metastasis (P=0.034) and high Ki-67 index (P=0.031). Multivariate Cox regression analysis revealed that DTX1 expression was recognized as an independent prognostic factor for MFS in breast cancer. Elevated levels of Notch1, Jagged1 and HES1 in NOTCH pathway and p-Akt/PKB in PI3K/AKT pathway were found in breast cancer cells with lower DTX1 expression. GSI treatment could inhibit breast cancer cell proliferation and migration through NOTCH/DTX1/PI3K/AKT pathways. Conclusion Lower DTX1 in breast tissues was associated with advanced condition, prognosis and metastasis of breast cancer. Lower DTX1 might promote breast cancer cell proliferation and migration via NOTCH/DTX1/PI3K/AKT pathways. DTX1 might be useful as a marker to select new therapy for breast cancer.
Leisure-time physical activity and gastric cancer risk: a pooled study within the Stomach cancer Pooling (StoP) Project
Authors: Stojanovic Jovana , Giraldi Luca , Johnson Ken C , Hu Jinfu , Torre Antonio Molina de la , Fernández-Tardón Guillermo , Zaridze David , Maximovich Dmitry , Negri Eva , Vecchia Carlo La , Zhang Zuo-Feng , Kurtz Robert C , Pelucchi Claudio , Rota Matteo , Pastorino Roberta , Boccia Stefania
Published: March 2020

Background Physical activity (PA) has been recognized as a protective factor against several types of cancer, though robust evidence related to Gastric Cancer (GC) are lacking. This study aimed to establish whether leisure-time PA can prevent GC using data from a large pooled analysis of case-control studies within the Stomach cancer Pooling (StoP) Project.Methods Five case-control studies from StoP project collected data on PA, for a total of 2,415 cases and 9,722 controls. Subjects were classified into three leisure-time PA categories, either none/low, intermediate or high, based on study-specific tertiles. We used a two-stage approach. Firstly, we applied multivariable logistic regression models to obtain study-specific odds ratios (ORs) and corresponding 95% confidence intervals (CIs). Afterwards, we used a random-effect models for estimating pooled effect estimates. Heterogeneity across studies was assessed using Q and I 2 statistics. We performed stratified analyses according to demographic, lifestyle and clinical covariates.Results The pooled ORs for GC risk were 0.90 (95% CI: 0.72, 1.13) for intermediate, and 0.72 (95% CI: 0.57, 0.91) for high levels of leisure-time PA. There was no evidence of significant heterogeneity in outcome estimates ( I 2 = 49.7%; p=0.094 for intermediate; I 2 = 42.9%, p=0.135 for high levels of exposure). GC risk estimates did not differ across strata of selected covariates.Conclusions Our study is the largest pooled analysis that provides insights about protective effects of high levels of recreational PA on GC risk. Although our results should be confirmed from large cohort studies, the implications have relevant public health significance.
The novel coronavirus infection pneumonia in Zhejiang province, China: early transmission dynamics, the government measures, and current situation of diagnosis and treatment
Authors: junwen Shen , yu Chen , jianer Tang , rongjiang Wang , zhihai Fang , jianxiang Yao , bingyao Liu , ying Zhou , zhanqing shi
Published: March 2020

Objective: to analyze the early transmission dynamics, the government measures, and current situation of diagnosis and treatment for novel coronavirus infection pneumonia in Zhejiang province, china.Methods: We collected the daily number of newly confirmed novel coronavirus infection pneumonia (NCP) patients and the number of discharge patients by February 8 in Zhejiang province. We analyzed the characteristics, exposure history, and the clinical symptoms of NCP patients.Results: there were 1075 confirmed NCP patients and 173 discharge patients in Zhejiang province by February 8. The daily number of newly confirmed NCP patients got decreased since January 29 (27 patients on February 8), while the daily number of newly discharge NCP patients was increasing (46 patients on February 8). Before February 1, the imported NCP patients contained the most significant part of total NCP patients. And the local infection of NCP patients occupied the main reason. 77 patients needed to stay in ICU. 26 of 77 patients had greater life danger. Fortunately, no patient was dead, and no health care worker got the infection. At the same time, the government of Zhejiang province strictly restricted the movement of people to prevent the NCP from further spread.Conclusion: The early spread of NCP in Zhejiang province was speedy. After the government of Zhejiang province took strict measures to restrict the movement of people, the difficult situation of NCP got noticeable relief in Zhejiang province since February 1.
Swelling capacity of mixed talc-like/stevensite layers in white/green clay infillings (“deweylite”/ “garnierite”) from serpentine veins of faulted peridotites, New Caledonia
Authors: Fonteneau Lionel , Caner Laurent , Petit Sabine , Juillot Farid , Ploquin Florian , Fritsch Emmanuel
Published: March 2020

White (Mg-rich) and green (Ni-rich) clay infillings (“deweylite”/ “garnierite”) found in serpentine veins of faulted peridotite formations from New Caledonia consist of an intimate mixture of fine-grained and poorly ordered 1:1 and 2:1 layer silicates, commonly referred to as non-expandable serpentine-like (SL) and talc-like (TL) minerals. New data on the swelling and shrinking capacity of these layer silicates were gathered from X-ray diffraction (XRD) after saturation of the clay fractions with different cations (Ca2+, Li+, K+), ethylene glycol (EG) solvation, and heat treatments. Simultaneously, layer charge distribution and vacancy density, respectively, were investigated by FTIR spectroscopy on NH4-saturated clay fractions and XRD on Li-saturated clay fractions before and after heating (Hofmann Klemen treatment). Five clay infillings, with dominant 2:1 layer silicates and variable Ni contents, were selected for this study, from a large set of veinlets, according to their swelling capacity. The crystal chemistry of these samples was characterized by FTIR spectroscopy and bulk chemical analyses.

The swelling ability of the clay infillings is attributed to the 2:1 layer silicates. It does not seem to be affected by the relative fraction of Mg and Ni in their octahedral sheets. In XRD patterns, the swelling ability is reflected by slight shifts of the basal reflection of the 2:1 layer silicates toward low angles for bulk samples and by splitting of the peak into two contributions for clay fractions saturated with Ca (or Li) and solvated with EG. The split increases with the swelling capacity of the sample. It originates mainly from octahedral-layer charge generated by vacant sites. Such results lead us to consider the 2:1 layer silicates of the infillings as an intimate mixture of non-expandable (TL) and expandable (stevensite) phases. In agreement with previous studies that suggested a contribution of hydrothermal processes in the alteration of serpentine species into 2:1 layer silicates, we propose that the proportion of expandable phases in the clay infillings (or vacancy sites in the octahedral sheets of the 2:1 layer silicates) could be used as an efficient means for assessing the temperature of their formation. Clay infillings mostly made of stevensite would have formed at ambient temperatures, whereas those consisting mainly of non-expandable TL would have formed at higher temperatures.
Symmetry resolved entanglement in gapped integrable systems: a corner transfer matrix approach
Authors: Murciano Sara , Di Giulio Giuseppe , Calabrese Pasquale
Published: March 2020

We study the symmetry resolved entanglement entropies in gapped integrable lattice models.
We use the corner transfer matrix to investigate two prototypical gapped systems with a U(1) symmetry: the complex
harmonic chain and the XXZ spin-chain.
While the former is a free bosonic system, the latter is genuinely interacting.
We focus on a subsystem being half of an infinitely long chain.
In both models, we obtain exact expressions for the charged moments and for the symmetry resolved entropies.
While for the spin chain we found exact equipartition of entanglement (i.e. all the symmetry resolved entropies are the same),
this is not the case for the harmonic system where equipartition is effectively recovered only in some limits.
Exploiting the gaussianity of the harmonic chain, we also develop an exact correlation matrix approach to the symmetry resolved entanglement that allows us to
test numerically our analytic results.
Municipal bonds as a tool for financing capital investment in local government units in Palestine
Authors: Zedan Khaled , Daas Ghassan , Awad Yaqin
Published: March 2020

Municipal bonds are an option available to many cities to raise long-term financing to finance the infrastructure projects. This study aims to develop and find local measures of creditworthiness that are suitable and applicable for local government units in Palestine. Different variables are recognized to see the effect on the issuance of municipal bonds, macroeconomic variables measured by revenues and expenditures per capita, cost of capital, and unemployment rate. Municipal status variables have subgroup variables of municipality size, financial reporting quality, outstanding debt, and financial distress. Various financial ratios, comparative and cross-sectional analysis, horizontal and vertical analysis were used. These ratios and analysis have been used to determine the municipal status variable. The results of the study were limited to the largest 11 sample municipalities; each is the central local government unit at the governorates and was not generalized for all municipalities in Palestine. The study found that macroeconomic and municipality status affects the issuance of municipal revenue bonds. Based on the study results, municipal bonds are highly recommended. Also, instructions from the Ministry of Local Government need to be established and to enforce municipalities about the declaration date of publishing audited financial statements.
Metody obrazowania i planowania w radioterapii-sprawozdanie z wybranych wystąpień na 37. spotkaniu ESTRO w Barcelonie.
Authors: Zychowicz Jagoda
Published: March 2020

W celu uaktualnienia wiedzy dotyczącej metod planowania i obrazowania w radioterapii dokonano analizy wybranych doniesień naukowych przedstawionych na 37. ESTRO FORUM konferencji Europejskiego Towarzystwa Radioterapii i Onkologii (European Society for Radiotherapy & Oncology, ESTRO). Realizując panel wystąpień ustnych dla elektroradiologów w zakresie wiedzy na temat metod obrazowania poruszono między innymi zagadnienia dotyczące konturowania narządów krytycznych, które zostaną pokrótce opisane w tej pracy.
The effect of the combination of TGF-β1 and BMP2 with high-density pellet cell culture during chondrogenic differentiation of pluripotent stem cells.
Authors: Lach Michał , Suchorska Wiktoria M.
Published: March 2020

Introduction: The osteoarthritis is a serious threat for well-developed and ageing countries. Present techniques of treatment of damaged cartilage are not sufficient. Hence, new strategies should be developed. One of the potential sources for the regeneration of cartilage is pluripotent stem cells (PSC). Aim: The development of an efficient protocol of chondrogenic differentiation using PSC. Material and methods: The human embryonic stem cell line (BG01V) was used in this study. The chondrogenic differentiation was performed using high-density pellet culture in the presence of TGF-β1 (10 ng/ml) and BMP2 (100 ng/ml). After 21 days gene expression analysis of markers related to chondrogenesis was done. Additionally, the histological staining was performed to detect the deposition of proteoglycans and collagens in differentiated pellet culture. Results: Obtained pellets exhibited decreased expression of pluripotent markers. The upregulation of mesodermal marker and type II collagen was observed in differentiated pellets in the presence of applied growth factors. The histological analysis revealed mild deposition of proteoglycans and collagens. Conclusion: The presented approach enables to obtain chondrogenic pellets in their early stages of chondrogenesis.
Phylogenomic Analysis of R2R3 MYB Transcription Factors in Sorghum and their Role in Conditioning Biofuel Syndrome
Authors: Singh Vinay , Kumar Neeraj , Dwivedi Anuj K. , Sharma Rita , Sharma Manoj K.
Published: March 2020

Background :

Large scale cultivation of sorghum for food, feed, and biofuel requires concerted
efforts for engineering multipurpose cultivars with optimised agronomic traits. Due to their vital
role in regulating the biosynthesis of phenylpropanoid-derived compounds, biomass composition,
biotic, and abiotic stress response, R2R3-MYB family transcription factors are ideal targets for improving
environmental resilience and economic value of sorghum.

Methods:

We used diverse computational biology tools to survey the sorghum genome to identify
R2R3-MYB transcription factors followed by their structural and phylogenomic analysis. We used inhouse
generated as well as publicly available high throughput expression data to analyse the R2R3 expression
patterns in various sorghum tissue types.

Results:

We have identified a total of 134 R2R3-MYB genes from sorghum and developed a framework
to predict gene functions. Collating information from the physical location, duplication, structural
analysis, orthologous sequences, phylogeny, and expression patterns revealed the role of duplications
in clade-wise expansion of the R2R3-MYB family as well as intra-clade functional diversification.
Using publicly available and in-house generated RNA sequencing data, we provide MYB candidates
for conditioning biofuel syndrome by engineering phenylpropanoid biosynthesis and sugar signalling
pathways in sorghum.

Conclusion:

The results presented here are pivotal to prioritize MYB genes for functional validation
and optimize agronomic traits in sorghum.
QSAR and Molecular Docking Studies on a Series of 1-Amino-5H-pyrido [4, 3-b]indol-4-carboxamides Acting as Janus Kinase 2 (JAK2) Inhibitors
Authors: Shaik Basheerulla , Gupta Satya P. , Zafar Tabassum , Anita K.
Published: March 2020

Background:

The Janus enzyme family is regulated by various cytokines together with
interleukins, interferons, and hormones like glycoprotein, thromboprotein, and hormone. Metamorphosis
and translocations in the Janus Kinase genes leading to constitutively active Janus Kinase
proteins are associated with a variety of hematopoietic malignancies, comprising the myeloproliferative
disorders, acute lymphoblastic leukemia, acute myeloid leukemia (JAK2, JAK1), acute
megakaryoblastic leukemia (JAK2, JAK3). Hence the study of the inhibitors of Janus Kinase is
desired.

Methods:

Research and online content related to 1-amino-5H-pyrido [4,3-b]indol-4-carboxamide
analogues (I) that were synthesized and evaluated for their JAK2 inhibitory activity is reviewed,
and in order to design and develop still better and more effective JAK inhibitors, we have
made Quantitative Structure Activity Relationship (QSAR), docking and ADMET studies on these
compounds

Results:

The best GA-MLR equation based on four descriptors along with statistical parameters is
obtained using QSARINS software. Using the model expressed by this study we predicted some
new compounds of high JAK2 inhibition potency. Each predicted compound has very high potency
with which only a few compounds of existing series can match.

Conclusion:

The QSAR and molecular modelling studies suggested that still better compounds can
be designed if the flexibility of the molecules can be increased for which attempts can be made to
have more saturated atoms in the molecules. Such a compound predicted by us was found to have
interactions with the enzyme JAK2 almost in the same manner as the FDA approved compound,
Momelotinib.
A nemzetközi diplomamobilitás stratégiai irányvonalai – a Magyarországon tanulmányokat folytató külföldi hallgatók motiváció, valamint a külföldi tanulmányokat befolyásoló tényezők vizsgálata
Authors: Bocskei Elvira , Bacs Zoltan , Kovacs Barnabas , Tarnoczi Tibor , Fenyves Veronika
Published: March 2020

Kutatásunk során a Magyarországon tanulmányokat folytató külföldi hallgatók motivációit vizsgáltuk. Kérdőíves kutatásunk célja az volt, hogy mind a keresleti,mind a kínálati oldalon feltárjuk azokat a lehetőségek, amelyek alapján a hazájukon kívül tanulmányokat folytatni kívánó fiatalok Magyarországot, mint lehetséges célországot jelölik meg. A kutatás első fázisában a befelé irányuló hallgatói mobilitás statisztikai vizsgálatát végeztük el. A magyar felsőoktatásról alkotott kép azért is érdekes, mert ugyan a legtöbb hallgatót küldő országok között ma még a közvetlen szomszédos országokat találjuk (Szlovákiát, Romániát, Szerbiát és Ukrajnát), ugyanakkor Norvégia mellett az ázsiai (Kína, Irán) és afrikai (Nigéria) országok hallgatóinak dinamikus növekedése figyelhető meg (Oktatási Hivatal statisztikai adatbázisa). A kutatás második fázisában került sor a kérdőíves felmérésre, amellyel arra kerestük a választ, hogy:– milyen tényezők játszottak szerepet abban, hogy a külföldi hallgató hazáján kívül folytasson tanulmányokat (mikor döntött a külföldi tanulás mellett, honnan szerezte információit, melyek voltak azok a tényezők, amelyek befolyásolták ország- és intézményválasztását stb.),– mennyiben elégedett a választott képzéssel, az oktatásszervezéssel, továbbá a képzés befejezését követően mik a jövőbeni tervei,– a képzési, megélhetési költségek alakulására vonatkozó milyen előzetes információkkal rendelkezett, melyek voltak a finanszírozás forrásai, hogyan alakultak a megélhetési költségei, illetve megtérültek-e ezek a költségek, milyen volt a szabadidő és a tanulás aránya, valamint a szabadidő eltöltésének lehetőségei,– mennyiben elégedett az intézményi szolgáltatásokkal (technikai felszereltséggel, oktatótermek felszereltségével, könyvtári szolgáltatással, intézményi programokkal).Cikkünkben, a terjedelmi korlátokra való tekintettel, a külföldi tanulmányokat befolyásoló tényezők vizsgálatára térünk ki.

Journal of Economic Literature (JEL) kódok: I2, J1
Munkáltatói kompetenciaelvárások vizsgálata piaci környezetben
Authors: Tothne Teglas Tunde , Hledik Erika
Published: March 2020

A vállalati körökben készített felmérések, munkaerőpiaci prognózisok arra hívják fel a figyelmet, hogy a munkaerőpiacon megfigyelhető változások a munkavállalás minőségi követelményeit is jelentősen átalakítják. A szakértők ezen kompetenciaelvárások bővülését és átrendeződését prognosztizálják. A munkavállalók ugyanakkor elhelyezkedésük során nagyon eltérő követelményeket tapasztalhatnak. Vannak munkáltatók, akiknek kifejezetten magasak az elvárásaik, de természetesen nem mindenhol érezhetők ezek. Tanulmányunkban a diplomás pályakezdőkkel szembeni kompetenciaelvárások megismerését szolgáló kvalitatív kutatásunk eredményei alapján arra keressük a választ, hogy vajon a hazai vállalatok hogyan reagálnak a változásokra munkavállalóikkal szemben támasztott követelményeik megfogalmazása során. Azt vizsgáljuk a prognózisok tükrében, hogy mely kompetenciák mentén tapasztalható már napjainkban is, hogy új, bővülő tartalommal gondolkodnak a munkáltatók. Munkánkban a kompetenciákat dinamikus változóként kezelve a diplomás pályakezdőkkel szembeni kompetenciaelvárások alakulását a keresleti oldal, azaz a munkáltatók szervezeti működésükhöz szükségek kompetenciaigényei, valamint a kínálati oldal, azaz a pályakezdők felkészültségével kapcsolatos tapasztalataik kölcsönhatásában vizsgáljuk.

Journal of Economic Literature (JEL) kódok: J23, J24, J53
Поляризационные процессы в тонких слоях аморфного MoS-=SUB=-2-=/SUB=-, полученных методом высокочастотного магнетронного распыления
Authors: Кононов А.А. , Кастро Арата Р.А. , Главная Д.Д. , Стожаров В.М. , Долгинцев Д.М. , Сайто Ю. , Фонс П. , Анисимова Н.И. , Колобов А.В.
Published: March 2020

Abstract The polarization processes in thin layers of amorphous molybdenum disulfide MoS_2 are studied by dielectric spectroscopy techniques. The process of dipole-relaxation polarization is observed. The microscopic parameters of the system are calculated, and the relaxation time of the dipole-polarization process, as well as the activation energies E _ a and E _σ of the relaxation process and conductivity, respectively, are determined. The fact that the two activation energies are close to each other suggests that the processes of relaxation and charge transport are driven by the same mechanism.
Формирование двухфазной структуры в металлоорганическом перовските CH-=SUB=-3-=/SUB=-NH-=SUB=-3-=/SUB=-PbI-=SUB=-3-=/SUB=-
Authors: Амасев Д.В. , Михалевич В.Г. , Тамеев А.Р. , Саитов Ш.Р. , Казанский А.Г.
Published: March 2020

The effect of annealing of organometallic perovskite CH3NH3PbI3 film on its electrical, photoelectric, and optical properties is studied. It was shown that annealing at Та>140 °C leads to the two-phase structure formation consisting of perovskite and lead iodide, the relative content of which depends on the annealing conditions, in particular, on its temperature. The PbI2 formation in the perovskite structure leads to a decrease in the conductivity and photoconductivity of the material. Our studies indicate the possibility of forming planar structures consisting of semiconductor materials with various values of the band gap: 1.6 eV (CH3NH3PbI3) and 2.4 eV (PbI2).
Транспортные процессы с участием атомов углерода между поверхностью и объемом родия при образовании и разрушении графена
Authors: Рутьков Е.В. , Афанасьева Е.Ю. , Галль Н.Р.
Published: March 2020

Equilibrium transport of atomic carbon between Rh surface and bulk has been studied. This transport controls the kinetics of the phase transition resulting in graphene growth or destruction. The difference ΔE=0.7 eV has been measured between the activation energy of atomic carbon dissolution E1s and that of its segregation from the bulk to the surface E1s. The temperature dependence of chemisorbed carbon critical cover Neq = Neq(T) has been measured, that is the cover when 2D phase transition takes place and graphene islands start to grow. E.g., Neq = 7.7•1014 cm-2 at T = 1800 K, and Neq = 3.1•1014 cm-2 at T = 1000 K.
Модификация рельефа n-поверхности AlGaInN-светодиодов изменением состава газовой смеси при реактивном ионном травлении
Authors: Марков Л.К. , Смирнова И.П. , Кукушкин М.В. , Павлюченко А.С.
Published: March 2020

Abstract The kind of profile produced during the reactive ion etching of AlGaInN light-emitting-diode (LED) heterostructures on the surface that became free after removal of the growth substrate is studied in relation to the composition of the gas mixture used in the etching process. It is shown that using a mixture composed of Cl_2 and Ar, taken in a 3:2 ratio in terms of flow rates, leads to the thinnest profile, whereas a 2 : 1 gas mixture of BCl_3 and Ar provides the largest structural elements. To study the effect of the kind of profile on the quantum efficiency (QE), flip-chip LEDs are fabricated on a silicon substrate. The LEDs are etched in different modes after the growth substrate is removed. Etching in the Cl_2:BCl_3:Ar mixture with a flow ratio of 6:10:11, which leads to intermediate sizes of the etching profile elements, is optimal for obtaining maximum light extraction from a LED chip at a wavelength of 460 nm. The variation of the kind of profile with the gas-mixture composition suggests that the profile parameters can be tuned to the wavelength used. An analysis of how the QE of LED chips depends on the etching duration in the three-component mixture under consideration results in that the optimum etching duration is estimated to be ~30 min. The results of the study can also be of use in the search for conditions minimizing the reflection of incident light by a chip, e.g., for photodetectors.
Кремниевые светодиоды с люминесценцией (113) дефектов
Authors: Калядин А.Е. , Штельмах К.Ф. , Аруев П.Н. , Забродский В.В. , Карабешкин К.В. , Шек Е.И. , Соболев Н.А.
Published: March 2020

Silicon light-emitting diodes with luminescence associated with (113) defects have been fabricated using implantation of 350 keV oxygen ions at the dose of 3.7∙1014 cm-2 and subsequent annealing at 700ᵒC for 1 h in a chlorine-containing atmosphere. Electroluminescence was studied in wide ranges of temperature and an excitation power. The line associated with (113) defects dominates in all the spectra. The temperature dependence of the line intensity depends on the excitation power in the range of low temperatures: an increase of the intensity with activation energy of 25 meV is observed at low current density and, with the increasing current density, a rise of the intensity is not observed. At higher temperatures, a decrease of the intensity with activation energy of 59 meV occurs regardless of a current density. With the increasing temperature, the peak of the line shifts by the same energy as the forbidden gap width, while the half width of the line grows linearly.
Cognition in Context: Understanding the Everyday Predictors of Cognitive Performance in a New Era of Measurement
Authors: Weizenbaum Emma , Torous John , Fulford Daniel
Published: March 2020

Background

Research suggests that variability in attention and working memory scores, as seen across time points, may be a sensitive indicator of impairment compared with a singular score at one point in time. Given that fluctuation in cognitive performance is a meaningful metric of real-world function and trajectory, it is valuable to understand the internal state-based and environmental factors that could be driving these fluctuations in performance.

Objective

In this viewpoint, we argue for the use of repeated mobile assessment as a way to better understand how context shapes moment-to-moment cognitive performance. To elucidate potential factors that give rise to intraindividual variability, we highlight existing literature that has linked both internal and external modifying variables to a number of cognitive domains. We identify ways in which these variables could be measured using mobile assessment to capture them in ecologically meaningful settings (ie, in daily life). Finally, we describe a number of studies that have already begun to use mobile assessment to measure changes in real time cognitive performance in people’s daily environments and the ways in which this burgeoning methodology may continue to advance the field.

Methods

This paper describes selected literature on contextual factors that examined how experimentally induced or self-reported contextual variables (ie, affect, motivation, time of day, environmental noise, physical activity, and social activity) related to tests of cognitive performance. We also selected papers that used mobile assessment of cognition; these papers were chosen for their use of high-frequency time-series measurement of cognition using a mobile device.

Results

Upon review of the relevant literature, it is evident that contextual factors have the potential to meaningfully impact cognitive performance when measured in laboratory and daily life environments. Although this research has shed light on the question of what gives rise to real-life variability in cognitive function (eg, affect and activity), many of the studies were limited by traditional methods of data collection (eg, involving retrospective recall). Furthermore, cognition has often been measured in one domain or in one age group, which does not allow us to extrapolate results to other cognitive domains and across the life span. On the basis of the literature reviewed, mobile assessment of cognition shows high levels of feasibility and validity and could be a useful method for capturing individual cognitive variability in real-world contexts via passive and active measures.

Conclusions

We propose that, through the use of mobile assessment, there is an opportunity to combine multiple sources of contextual and cognitive data. These data have the potential to provide individualized digital signatures that could improve diagnostic precision and lead to meaningful clinical outcomes in a wide range of psychiatric and neurological disorders.
Risks and Benefits of Web-Based Patient Narratives: Systematic Review
Authors: Drewniak Daniel , Glässel Andrea , Hodel Martina , Biller-Andorno Nikola
Published: March 2020

Background

Patient narratives are illustrative, individual accounts of patients’ experiences with certain health conditions. Web-based patient narratives have become widely available on the internet and in social media, as part of electronically available patient decision aids or Web-based databases. In recent years, the role of patient narratives as a source of information, insight, and support for both health care users and providers has increasingly been emphasized. Although the potential impact of patient stories has high immediate plausibility, it is of interest to know if this impact can be captured in quantitative studies.

Objective

This review aimed to evaluate whether research-generated Web-based patient narratives have quantifiable risks or benefits for (potential) patients, relatives, or health care professionals.

Methods

We searched the following databases from August 2017 to March 2019: Medical Literature Analysis and Retrieval System Online, PsycInfo, Sociological Abstracts, Web of Science, and EMBASE. Titles and abstracts of the retrieved studies were reviewed and assessed for the inclusion and exclusion criteria. Papers were included if they studied the following: (1) (potential) patients, relatives, or health care professionals; (2) the effects of Web-based patient narratives that were generated scientifically (eg, through qualitative research methods); and (3) were quantitative studies. Furthermore, 2 authors independently performed an assessment of the quality of the included studies using a validated checklist.

Results

Of 4226 documents, 17 studies met the inclusion criteria. The studies investigated 10 different sources of Web-based patient narratives. Sample sizes ranged from 23 to 2458. The mean score of the quality assessment was 82.6 (range 61-100). Effects regarding five different purposes were identified as follows: provide information, engage, model behavior, persuade, and comfort. We found positive effects in every category and negative effects in one category (persuade). Several of the reported effects are rather small or were identified under specific experimental conditions.

Conclusions

Patient narratives seem to be a promising means to support users in improving their understanding of certain health conditions and possibly to provide emotional support and have an impact on behavioral changes. There is limited evidence for beneficial effects on some outcomes. However, narratives are characterized by considerable heterogeneity and the investigated outcomes are hardly comparable with each other, which makes the overall judgment difficult. As there are numerous possible measures and purposes of narratives, quantifying the impact of Web-based patient narratives remains a challenge. Future research is needed to define the optimal standards for quantitative approaches to narrative-based interventions.
Analisis Efektivitas Biaya Terapi Antihipertensi Kombinasi Tetap Di Satu Rumah Sakit Jakarta Selatan
Authors: Rahayu Ani , Afdhal Ahmad Fuad , Hasan Delina , Suwarna Feriadi , Meila Okpri
Published: March 2020

The majority of alternative antihypertensive therapies require pharmacoeconomic studies, particularly Cost Effectiveness Analysis, which is useful in balancing patients’ expenditure by determining alternative treatments that represented the most plausible health outcomes with a more reasonable budget. The objective of this study was to compare the cost effectiveness using antihypertensive fixed dose combinations (FDC) of Valsartan-Amlodipine + Furosemide and FDC of Valsartan-HCT + Amlodipin. This research applied the descriptive analytical cross-sectional method and conducted data collection retrospectively from the medical record of hypertensive patients. Meanwhile, the medication cost breakdown was obtained from Outpatient Financial Department of a Type B Hospital in south Jakarta for the period of January - June 2018. Total sample were 74 patients, consisted of 37 patients who used  FDC of Valsartan-Amlodipin + Furosemide, and 37 patients who used FDC of Valsartan-HCT + Amlodipin. The parameters of this research were direct medication cost (consisted of examination cost, laboratory cost and medicines cost), indirect medication cost (consisted accommodation cost and lost productivity cost), while the effectiveness used the MAP average (Mean Arterial Pressure). The result of this research showed that the biggest medication effectiveness to lower the blood pressure is FDC of  Valsartan-Amlodipin + Furosemide, with 32  patients had the average MAP 101,29 mmHg, while the FDC of Valsartan-HCT + Amlodipin with 29 patients had the average MAP 103,59 mmHg. The cost effectiveness based on ACER value of  FDC of Valsartan –HCT + Amlodipin and FDC Valsartan-HCT + Amlodipin sequentially is Rp 3.922.040/MAP and Rp 4.458.034/MAP. In conclusion, the FDC of Valsartan-Amlodipin + Furosemide  was more cost-effective.
Analisis Tingkat Kepuasan Pasien Rawat Inap terhadap Pelayanan Kefarmasian di Instalasi Farmasi RS X Tahuna
Authors: Citraningtyas Gayatri , Jayanto Imam , Nangaro Jesica , Nangaro Alfred
Published: March 2020

The level of satisfaction achievement on the services provided to patients, both the quality of health services and the health care system, will be the first choice for patients to visit the hospital. The objective of this study was to determine inpatients satisfaction level in the internal diseases room on drug services at Pharmacy Installation Hospital of X Tahuna. This research was a descriptive research with crosssectional design. The research instrument was a form of a questionnaire of hope and reality which was adopted from Nangaro in 2019. The validity and reliability test of the questionnaire was conducted on 30 respondents and data analysis using index of total quality service. There are 115 people who have met the inclusion criteria, such as being willing to be a respondent, being able to read and write, aged ≥ 18 years old, and were currently undergoing treatment in the interna room and have received service at X Tahuna Hospital. Analysis of satisfaction data was using the Weighted Servqual model. The results showed an overall satisfaction index of -0.20, while the satisfaction index for each dimension was as follows: -0.29 for the tangibles dimension, -0.278 emphaty dimensions, -0.17 reliability dimensions, -0.274 dimensions responsiveness, and - 0.32 for the assurance dimension. The overall satisfaction index as well as each dimension shows a negative value, which means that the patient is not satisfied with the drug services at X Tahuna Hospital Pharmacy Installation. The Hospital must re-evaluate the number of human resources (pharmacist-patient ratio), the flow of drug services, as well as the completeness of the available facilities.
As obrigações acessórias e as novas tendências em matéria de cumprimento cooperativo na administração tributária do estado de São Paul
Authors: Martins Fabio Andrade
Published: March 2020

Este artigo objetiva analisar as novas ações de cobrança e fiscalização de tributos, realizadas pela Administração Tributária de São Paulo, sob a luz dos princípios da eficiência e praticabilidade da tributação, mormente em relação à influência que podem exercer sobre a moral tributária dos contribuintes paulistas, considerando-se as limitações inerentes à capacidade institucional do órgão e as novas tendências em matéria de cumprimento tributário cooperativo.
Regulación y tributación en el mercado de criptoactivos, una perspectiva de derecho comparado
Authors: Chirinos Gabriel Alejandro
Published: March 2020

El presente artículo de investigación pretende exponer el masivo problema que presentan las Administraciones Tributarias en cuanto a la fiscalización y cobro a las transacciones realizadas con Criptoactivos, todo esto debido a la digitalización y apertura de los mercados actuales y la masividad de las operaciones que se realizan actualmente, además de abordar una definición que permita la garantía de los derechos del contribuyente explicando las formas que tiene la Administración de Intervenir en la economía, así como también, proveer a las Administraciones Tributarias el cómo abordar nuevas perspectivas que se adapten a la digitalización de los mercados e identificar cada uno de los elementos que constituyen la obligación tributaria en la sobrevenida intervención estatal en el mercado de Criptoactivos.
Actualidades en la higiene de manos quirúrgica. Revisión de la literatura
Authors: Mena-Gómez I.I.
Published: March 2020

Introducción: La higiene de manos quirúrgica, procedimiento esencial en cirugía; es una técnica que ha evolucionado y se ha ido actualizando tras el surgimiento de evidencia científica. El manual de la Organización Mundial de la Salud (OMS) publicado hace diez años es uno de los documentos que plasman cambios de esta técnica, como dejar de usar el cepillo. Sin embargo, es necesario analizar la evidencia actual con la finalidad de reconocer las nuevas tendencias de acuerdo con los resultados de las investigaciones publicadas. Objetivo: Realizar una revisión actualizada de la literatura sobre la higiene de manos quirúrgica. Desarrollo: El lavado de manos quirúrgico con cepillo es un procedimiento que se realiza en la mayoría de las instituciones hospitalarias de México; pocas han incursionado en la técnica en la que se omite el uso de cepillo. Existen diversos estudios que sustentan que el uso de cepillos debe ser erradicado debido al daño tisular que estos ocasionan. La abrasión dérmica provocada por el uso de cepillos origina que el personal se cepille las superficies de las manos y brazos por menos tiempo que el recomendado y esto a su vez impide un efecto idóneo por parte de los antisépticos. Las sustancias más recomendadas son la clorhexidina y las soluciones a base de alcohol. Conclusiones: La higiene de manos quirúrgica sin cepillo debe ser considerada debido a que disminuye costos hospitalarios, garantiza la efectividad de la descontaminación de manos, ocasiona menos lesiones dérmicas y contribuye a la reducción de las infecciones relacionadas al sitio quirúrgico.
Pelatihan Help-Seeking Need Analysis pada Siswa
Authors: Sulaiman Ahmad , Suryaningrum Cahyaning
Published: March 2020

Help-Seeking merujuk pada intensi, aksi dan evaluasi untuk mendapatkan pertolongan belajar dari sumber external. Help-Seeking menjadi penting karena ia mengizinkan siswa untuk mengatasi kesulitan belajar yang tidak dapat ia selesaikan sendiri. Sayangnya, alih-alih memiliki sikap yang positif terhadap Adaptive Help-Seeking, siswa-siswa kebanyakan mengandalkan Executive Help-Seeking atau permohonan tolong akademik yang sekedar bertujuan untuk menggugurkan tugas dan kesulitan belajar seperti dengan melimpahkan tugas dan kesulitas belajar itu kepada orang lain. Untuk mengatasi hal itu, dilakukan pelatihan Help-Seeking Need Analysis. Program itu bertujuan untuk membekali siswa dengan pengetahuan mengenai Help-Seeking baik yang adaptive dan executive. Dengan mengembangkan skema mengenai Adaptive Help-Seeking, diharapkan siswa mampu mengadopsi pola pencarian tolong akademik yang adaptif. Metode pengumpulan data dilakukan dengan penyebaran skala Adaptive Help-Seeking yang telah divalidasi. Hasil analisis terhadap data menunjukkan bahwa dilatih mengembangkan sikap yang lebih positif terhadap Adaptive Help-Seeking. Luaran dari program ini adalah modul pelatihan dan artikel ilmiah.
Psikoedukasi Kebersyukuran Kepada Tuhan
Authors: Susanti Rizky , Dewi Yolanda Kartika , Ayuwarningsih Rani
Published: March 2020

Masa remaja adalah masa peralihan dari anak-anak ke dewasa. Di masa remaja banyak sekali terjadi perubahan pada diri anak. Mulai dari fisik, emosi dan kognitif. Perubahan-perubahan itu memengaruhi perilaku remaja itu sendiri. Oleh karena itu, di masa remaja sering kali menjadi masa-masa yang rawan masalah. Salah satu penyelesaian yaitu dengan adanya rasa syukur kepada Tuhan. Tujuan kegiatan pengabdian masyarakat yaitu untuk memberikan psikoedukasi tentang kebersyukuran kepada Tuhan. Mitra kegiatan yaitu panti asuhan putri aisiyah Malang. Hasil dari pengabdian ini menggambarkan bahwa secara keseluruhan remaja panti asuhan memiliki kebersyukuran yang sedang dengan aspek yang paling dominan yaitu pada aspek grateful, sedangkan skor terendah pada aspek thankful.
Training Manajemen Diri Pada Siswa Akselerasi MAN 1 Malang
Authors: Djudiyah Djudiyah , Haq Ihsanul , Rahmah Makkiyatur
Published: March 2020

Masa remaja adalah masa peralihan dari anak-anak ke dewasa. Di masa remaja banyak sekali terjadi perubahan pada diri anak. Mulai dari fisik, emosi, dan kognitif. Perubahan-perubahan itu mempengaruhi hakekat relasi orang tua dan remaja itu sendiri. Oleh karena itu, di masa remaja seringkali menjadi masa-masa yang kritis. Karena pada tahapan inilah seseorang mencari identitas dirinya. Fakta-fakta tersebut juga terdapat pada siswa akselerasi di MAN I Malang, beberapa anak mengalami kesulitan dalam mengelola dirinya sehingga membuat belajarnya tidak maksimal pada hal tuntutan akademik sangat tinggi dengan adanya batasan masa studi selama dua tahun. Selain itu, banyak keluhan yang disampaikan oleh para guru khususnya guru Bimbingan Konseling bahwa terdapat beberapa masalah yang perlu mendapat perhatian khusus, yaitu terkait dengan pengembangan soft skill sehingga perlu kiranya dilakukan pendampingan khusus dalam rangka memberikan fasilitas untuk pengembangan diri siswa akselerasi.  Hasil dari pengabdian ini menggambarkan bahwa siswa akselerasi sangat tertarik dengan kegiatan ini dan melalui kegiatan ini siswa akselerasi dapat mengetahui potensi psikologisnya sehingga membantu siswa akselerasi dapat lebih mudah untuk mengoptimalkan potensi-potensinya.
ANADOLU BASINININ (ORTA KARADENİZ BÖLGESİ YEREL BASINININ) SORUNLARI VE ÇÖZÜMLER
Authors: İMRE Nurettin
Published: March 2020

Türkiye’de ilk basımevini kurma onuru III. Ahmed’in Sadrazamı Nevşehirli Damat İbrahim Paşa’nın izni ile İbrahim Müteferrika ile 28 Çelebizade Sait Efendi’lerindir. İlk Türkçe gazete, Tanzimat döneminde yayınlanan Takvim-i Vakayi’dir. Anadolu’da, Milli Mücadelenin doğup gelişmesiyle birlikte Anadolu Basını doğmuş ve gelişmiştir. Baskı makinaları at ve öküz arabalarıyla ilden ile taşınmış ve en ilkel koşullar altında gazeteler yayınlanmıştır. Mustafa Kemal, milli davamızı dünya kamuoyuna ulaştırmak ve yurt içinde halkı, bu büyük amaca yöneltmek için 6 Nisan 1920’de Anadolu Ajansı’nı kurmuştur. Dar olanaklar içinde, sadece ve sadece memleket sevgisi, gazetecilik heyecanı ile dolu olarak okuyucuya hizmet götüren, kamuoyu oluşumunda da ilk halka görevini yapan Yerel Basın, kitle iletişim araçlarının öncüsü olmuştur. Fakat yerel basın ulusal basın yanında sürekli ikinci planda kalmış ve hak ettiği değeri görmemiştir. Bu çalışmada Orta Karadeniz Bölgesindeki Amasya, Çorum, Ordu, Samsun, Tokat illeri ve ilçelerinde bulunan yerel basına ait anket çalışmaları yapılmıştır. Bu illerdeki gazetelerin sorunları belirlenmiş ve çözüm önerileri getirilmiştir.
Lawrence S. Kaplan's 'Thomas Jefferson - Westward the Course of Empire'
Authors: Harding David
Published: March 2020

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Elisabeth Kraus and Carolin Auer's (eds) 'Simulacrum America: The USA and the Popular Media'
Authors: Tabbi Joe
Published: March 2020

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The relation between cash flows and economic performance in the digital age: An empirical analysis
Authors: Ferri Salvatore , Tron Alberto , Fiume Raffaele , Della Corte Gaetano
Published: March 2020

Cash flows analysis plays an increasingly important role in the study of business dynamics since cash flows play a key role in the company's economic performance, not only from a standpoint but also in predictive terms. The literature on the subject is poor in number and depth of research, the samples analyzed so far are limited and the statistical tools are weak. Retracing the steps of past research, we studied the relationships between cash flows of several management areas and economic performance, using a complete sample of Italian listed companies in the 2008-2017 period with more solid statistical tools compared to previous studies. The database used to collect all the balance sheet data necessary to conduct our research is Amadeus of the Bureau Van Dijk platform, which already shows reclassified and easily comparable financial statements. Correlation and multiple regression analysis were used to assess if our cash flow proxies could be strong predictors of future cash flow and, consequently, of business performance. The flows for investments and the ability to generate cash, where the latter is positively correlated with future profitability, manage to explain, together with the net cash generation of the company, a large part of the variability of the operating income produced in subsequent periods. The flows from investments seem to be the most suitable for correctly classifying the most profitable companies in the medium-long term, while cash generation, deriving from the characteristic activity, contributes to providing answers, about corporate profitability, on shorter time horizons.