bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of the combination of photobiomodulation therapy and the intralesional administration of corticoid in the preoperative and postoperative periods of keloid surgery: A randomized, controlled, double-blind trial protocol study
Authors: Pires Jefferson André , Bragato Erick Frank , Momolli Marcos , Guerra Marina Bertoni , Neves Leonel Manea , de Oliveira Bruscagnin Meire Augusto , Ratto Tempestini Horliana Anna Carolina , Porta Santos Fernandes Kristianne , Kalil Bussadori Sandra , Agnelli Mesquita Ferrari Raquel
Published: February 2022

Keloid scars are characterized by the excessive proliferation of fibroblasts and an imbalance between the production and degradation of collagen, leading to its buildup in the dermis. There is no “gold standard” treatment for this condition, and the recurrence is frequent after surgical procedures removal. In vitro studies have demonstrated that photobiomodulation (PBM) using the blue wavelength reduces the proliferation speed and the number of fibroblasts as well as the expression of TGF-β. There are no protocols studied and established for the treatment of keloids with blue LED. Therefore, the purpose of this study is to determine the effects of the combination of PBM with blue light and the intralesional administration of the corticoid triamcinolone hexacetonide on the quality of the remaining scar by Vancouver Scar Scale in the postoperative period of keloid surgery. A randomized, controlled, double-blind, clinical trial will be conducted involving two groups: 1) Sham (n = 29): intralesional administration of corticoid (IAC) and sham PBM in the preoperative and postoperative periods of keloid removal surgery; and 2) active PBM combined with IAC (n = 29) in the preoperative and postoperative periods of keloid removal surgery. Transcutaneous PBM will be performed on the keloid region in the preoperative period and on the remaining scar in the postoperative period using blue LED (470 nm, 400 mW, 4J per point on 10 linear points). The patients will answer two questionnaires: one for the assessment of quality of life (Qualifibro-UNIFESP) and one for the assessment of satisfaction with the scar (PSAQ). The team of five plastic surgeons will answer the Vancouver Scar Scale (VSS). All questionnaires will be administered one, three, six, and twelve months postoperatively. The keloids will be molded in silicone prior to the onset of treatment and prior to excision to assess pre-treatment and post-treatment size. The same will be performed for the remaining scar at one, three, six, and twelve months postoperatively. The removed keloid will be submitted to histopathological analysis for the determination of the quantity of fibroblasts, the organization and distribution of collagen (picrosirius staining), and the genic expression of TGF-β (qPCR). All data will be submitted to statistical analysis.

Trial registration: This study is registered in ClinicalTrials.gov (ID: NCT04824612).
Proton range monitoring using 13N peak for proton therapy applications
Authors: Islam M. Rafiqul , Shahmohammadi Beni Mehrdad , Ng Chor-yi , Miyake Masayasu , Rahman Mahabubur , Ito Shigeki , Gotoh Shinichi , Yamaya Taiga , Watabe Hiroshi
Published: February 2022

The Monte Carlo method is employed in this study to simulate the proton irradiation of a water-gel phantom. Positron-emitting radionuclides such as 11C, 15O, and 13N are scored using the Particle and Heavy Ion Transport Code System Monte Carlo code package. Previously, it was reported that as a result of 16O(p,2p2n)13N nuclear reaction, whose threshold energy is relatively low (5.660 MeV), a 13N peak is formed near the actual Bragg peak. Considering the generated 13N peak, we obtain offset distance values between the 13N peak and the actual Bragg peak for various incident proton energies ranging from 45 to 250 MeV, with an energy interval of 5 MeV. The offset distances fluctuate between 1.0 and 2.0 mm. For example, the offset distances between the 13N peak and the Bragg peak are 2.0, 2.0, and 1.0 mm for incident proton energies of 80, 160, and 240 MeV, respectively. These slight fluctuations for different incident proton energies are due to the relatively stable energy-dependent cross-section data for the 16O(p,2p2n)13N nuclear reaction. Hence, we develop an open-source computer program that performs linear and non-linear interpolations of offset distance data against the incident proton energy, which further reduces the energy interval from 5 to 0.1 MeV. In addition, we perform spectral analysis to reconstruct the 13N Bragg peak, and the results are consistent with those predicted from Monte Carlo computations. Hence, the results are used to generate three-dimensional scatter plots of the 13N radionuclide distribution in the modeled phantom. The obtained results and the developed methodologies will facilitate future investigations into proton range monitoring for therapeutic applications.
Effects of physical activity interventions using wearables to improve objectively-measured and patient-reported outcomes in adults following orthopaedic surgical procedures: A systematic review
Authors: Master Hiral , Bley Jordan A. , Coronado Rogelio A. , Robinette Payton E. , White Daniel K. , Pennings Jacquelyn S. , Archer Kristin R.
Published: February 2022

Objective

To synthesize evidence on physical activity interventions that used wearables, either alone or in combination with education or rehabilitation, in adults following orthopaedic surgical procedures.

Methods

PubMed, CINAHL, PsycINFO and EMBASE were searched for randomized controlled trials of wearable-based interventions from each database’s inception to August 2021 in patients undergoing orthopaedic surgery. Relevant outcomes included physical activity, physical function, pain, psychological distress, or general health. PEDro scale scoring ranges from 0 to 10 and was used to appraise studies as high (≥7), moderate (5–6), or poor (<5) quality.

Results

Of 335 articles identified, 6 articles met eligibility criteria. PEDro scores ranged from 2 to 6, with 3 studies of moderate quality and 3 of poor quality. Studies included patients undergoing total knee (number; n = 4) or total knee or hip (n = 1) arthroplasty and lumbar disc herniation surgery (n = 1). In addition to wearables, intervention components included step diary (n = 2), motivational interviewing (n = 1), goal setting (n = 2), tailored exercise program (n = 2), or financial incentives (n = 1). Interventions were delivered in-person (n = 2), remotely (n = 3) or in a hybrid format (n = 1). Intervention duration ranged from 6 weeks to 6 months. Compared to controls, 3 moderate quality studies reported greater improvement in steps/day; however, 1 moderate and 2 poor quality studies showed no between-group difference in physical function, pain, or quality of life. No serious adverse events related to the use of wearable were reported.

Conclusions

The effects of physical activity interventions using wearables, either delivered in-person or remotely, appear promising for increasing steps per day after joint arthroplasty; however, this finding should be viewed with caution since it is based on 3 moderate quality studies. Further research is needed to determine the therapeutic effects of using wearables as an intervention component in patients undergoing other orthopaedic surgical procedures.

Trial registration

PROSPERO Registration Number: CRD42020186103
Mathematical model of hormone sensitive prostate cancer treatment using leuprolide: A small step towards personalization
Authors: Foryś Urszula , Nahshony Alon , Elishmereni Moran
Published: February 2022

In this paper we present a new version of a mathematical model of Elishmereni et al. describing androgen deprivation therapy (ADT) for hormone sensitive prostate cancer patients (HSPC). We first focus on the detail description of the model, and then we present mathematical analysis of the proposed model, starting from the simplified model without resistance and ending on the full model with two resistance mechanisms present. We make a step towards personalization proposing an underlying tumor growth law base on a cohort of patients from Mayo hospital. We conclude that the model is able to reflect reality, that is in clinical scenarios the level of testosterone in HSPC patients inevitably rises leading to the failure of ADT.
Transportation to work by sexual orientation
Authors: Oreffice Sonia , Sansone Dario
Published: February 2022

We analyze differences in mode of transportation to work by sexual orientation, using the American Community Survey 2008–2019. Working individuals in same-sex couples are significantly less likely to drive to work than working men and women in different-sex couples. This gap is particularly stark among men: on average, almost 12 percentage point (or 13%) lower likelihood of driving to work for men in same-sex couples. Working individuals in same-sex couples are also more likely to use public transport, walk, or bike to work. Men and women are 7 and 3 percentage points more likely, respectively, to take public transportation to work than those in different-sex couples. Working men are also more likely to work from home–while working women are less likely–than those in different-sex couples. These differences persist after controlling for demographic characteristics, partner’s characteristics, location, fertility, marital status, occupation or industry, and family income. Additional evidence from the General Social Survey 2008–2018 suggests that these disparities by sexual orientation may be due to lesbian, gay, and bisexual individuals valuing the environment more than straight individuals.
Detecting and monitoring dental plaque levels with digital 2D and 3D imaging techniques
Authors: Giese-Kraft Katja , Jung Katja , Schlueter Nadine , Vach Kirstin , Ganss Carolina
Published: February 2022

Detecting and monitoring dental plaque is an important issue in research and clinical practice. In this context, new digital imaging methods that permit permanent documentation of the clinical findings could be promising tools. The aim of the study was therefore to investigate whether disclosed plaque can be reliably visualised on 2D and 3D images captured with digital intraoral imaging devices. Clinical examination was the reference method. Twenty subjects (27.5±1.2 years) were included and plaque was measured at three different stages: habitual plaque (T1), after 72 h without oral hygiene (T2) and after a subsequent habitual brushing exercise (T3). At each time point, plaque was disclosed followed by the clinical examination and capturing the 2D and 3D images (intraoral-camera CS 1500 and intraoral-scanner CS 3600; Carestream Dental, Germany). Plaque amounts were recorded on oral and vestibular surfaces of the Ramfjord-teeth (16, 21, 24, 36, 41, 44) using the Rustogi-modified-Navy-Plaque-Index (RMNPI) and expressed as percentage of plaque-containing RMNPI areas of all RMNPI areas. At T1, percentages (mean±SD) obtained from the clinical examination, 2D and 3D images were 62.2±10.6, 65.1±10.0 and 64.4±10.6 resp. increasing to 76.9±8.0, 77.9±8.6 and 77.5±9.4 resp. at T2. After toothbrushing (T3), values decreased to 56.3±11.1, 58.2±12.1 and 61.2±10.8 resp. All methods were able to show statistically significant changes in plaque amounts at the different time points with in part statistically significant but minor differences between them. The Bland-Altmann analysis revealed a good agreement between values from both 2D and 3D images with the clinical examination. The agreement of the scores obtained with the both image-based methods for the single RMNPI areas with the clinical examination was mainly classified as substantial to almost perfect. Amounts of plaque can be reliably detected and monitored on 2D images from an intraoral camera and on 3D images from an intraoral scanner.
The effects of exercise on body composition of prostate cancer patients receiving androgen deprivation therapy: An update systematic review and meta-analysis
Authors: Shao Wenjuan , Zhang Hanyue , Qi Han , Zhang Yimin
Published: February 2022

Androgen deprivation therapy is a common treatment for prostate cancer. However, this therapy is associated with various adverse effects, such as increased body fat and decreased bone mineral density. Exercise may be useful for ameliorating these adverse effects, although it is not completely effective. This review aimed to clarify how exercise interventions influenced body composition and bone mineral density and to explore the most effective exercise program among prostate cancer patients who received androgen deprivation therapy. We searched the PubMed, EMBASE, Web of Science, EBSCO, and Cochrane Library databases for reports of randomised controlled trials that were published until October 2021. All studies involved prostate cancer patients who received androgen deprivation therapy and completed aerobic exercise, resistance exercise, and/or impact exercise training. Outcomes were defined as lean body mass, body fat mass, body fat rate, regional and whole-body bone mineral density. Thirteen reports regarding 12 randomised clinical trials (715 participants) were included. Relative to the control group, exercise intervention provided a higher lean body mass (mean difference: 0.88, 95% confidence interval: 0.40 to 1.36, P<0.01), a lower body fat mass (mean difference: -0.60, 95% confidence interval: -1.10 to -0.10, P<0.05), and a lower body fat rate (mean difference: -0.93, 95% confidence interval: -1.39 to -0.47, P<0.01). Subgroup analyses revealed greater efficacy for exercise duration of ≥6 months (vs. <6 months) and exercise immediately after the therapy (vs. delayed exercise). No significant differences were observed in the bone mineral density outcomes. Exercise can help ameliorate the adverse effects of androgen deprivation therapy in body composition, with combination exercises including resistance exercise, 8–12 repetition maximum of resistance exercise intensity, prolonged exercise duration, and performing exercise immediately after therapy providing better amelioration. And the combination of resistance and impact exercise appears to be the best mode for improving the bone mineral density.
Young adults’ needs when seeking first-line healthcare: A grounded theory design
Authors: Viktorsson Lisa , Törnvall Eva , Falk Magnus , Wåhlin Ingrid , Yngman-Uhlin Pia
Published: February 2022

Background

Healthcare outpatient visits have increased in recent years, and young adults are often given as an explanatory factor for many avoidable visits.

Objective

The objective of this study was to explore how young adults perceive seeking first-line healthcare.

Design and setting

The study utilized a grounded theory design with data collection at primary healthcare centres and emergency departments in southeast Sweden.

Method

Data were collected during individual interviews and patient observations with subsequent interviews during the years 2017–2018. The analysis was performed using grounded theory.

Results

The main concern when young adults are seeking healthcare is that their worries are taken seriously. It is a four-part process: becoming aware of, verifying, communicating, and receiving an opinion about one’s symptoms. The process includes external factors, clarity of symptoms, behavioural approaches, healthcare know-how, enabling self-management, and prior healthcare experience(s). When communicating symptoms, the clearer the symptoms, the less there needs to be communicated. When symptoms are unclear, the importance of different behavioural approaches and healthcare know-how increases. When receiving a medical opinion about symptoms, young adults want to learn how to self-manage their symptoms. Depending on previous healthcare experience, the healthcare visit can either harm or help the patient in their healthcare-seeking process.

Conclusion

This study reflects several insights in the healthcare-seeking process from a young adult perspective. Based on the results, we suggest that healthcare providers focus on the final step in the healthcare-seeking process when giving their medical opinion about symptoms. Having extra minutes to give support for future self-care regardless of diagnosis could increase positive healthcare experiences and increase future self-care among young adults.
Prevalence and determinants of care needs among older people in Ghana
Authors: Awuviry-Newton Kofi , Ofori-Dua Kwadwo , Deku Charles Selorm , Abekah-Carter Kwamina , Awortwe Victoria , Oti George Ofosu
Published: February 2022

Introduction

Given the longevity noticed among older people in Ghana, and the potential occurrence of functional disability in later years of life, it has become essential to understand their care needs. This study examined the care needs in daily tasks and associated factors in Ghana, following the World Health Organisation International Classification of Functioning, Disability and Health framework.

Materials and methods

A cross-sectional survey was conducted among a sample of 400 older people from Komfo Anokye Teaching Hospital in Southern Ghana. Care need was assessed by one question; “Do you regularly need help with daily tasks because of long-term illness, disability, or frailty?” Multivariate logistic regression was used to test the association between care need and independent variables based on the WHO-ICF conceptual framework.

Results

Majority of the sample (81%), particularly women (54%) reported needing care in daily tasks. Per the WHO-ICF conceptual framework, functional disability—activity variable, (OR = 1.07 95%CI: 1.05–1.09, p<0.001), and absence of government support—an environmental factor, (OR = 3.96 95%CI: 1.90–8.25, p<0.001) were associated with care need.

Conclusions

The high prevalence of care needs among older people may offer an indication that majority of older people in Ghana could benefit from long-term care services. Functional disability and the absence of government support are the major issues that need to be prioritised in addressing the increased demand for care related to performing daily tasks among older people in Ghana.
The production technology of mineral soda alumina glass: A perspective from microstructural analysis of glass beads in Iron Age Taiwan
Authors: Wang Kuan-Wen , Iizuka Yoshiyuki , Jackson Caroline
Published: February 2022

Mineral soda alumina (m-Na-Al) glass is a common glass production group found around the Indo-Pacific region. In Iron Age Taiwan, its presence dates back to the early 1stmillennium AD. This research discusses m-Na-Al glass beads excavated from Iron Age sites in Taiwan. No production sites for m-Na-Al have been found, but microstructural analysis suggests m-Na-Al glass appears to originate around South Asia and is exchanged widely. SEM-EDS and EPMA were used to analyse red, orange, yellow, green and blue m-Na-Al glass. The microstructure of the glass shows the presence of plagioclase and alkali feldspar relics in the glass, suggesting a low manufacturing temperature. Copper-based colourants are identified in red, orange, blue and green glass, while lead tin oxide is used in yellow and green glass. It appears that various types of copper-containing raw materials were procured by craftspeople, and a self-reduction process for producing red and orange glass is tentatively proposed. Additionally, the microstructure of yellow glass reveals different colouring paths were used. These results increase our understanding of the selection of raw materials, and provide an impetus for further research on the cross craft interaction between glass and copper production.
FGFR2 overexpression and compromised survival in diffuse-type gastric cancer in a large central European cohort
Authors: Schrumpf Thorben , Behrens Hans-Michael , Haag Jochen , Krüger Sandra , Röcken Christoph
Published: February 2022

The significance of fibroblast growth factor receptor 2 (FGFR2) in gastric cancer (GC) has been studied predominantly in Asian patient cohorts. Data on White patients are scarce. Here, we aimed to independently validate the expression and putative tumor biological significance of FGFR2 in a large non-Asian GC cohort. Immunohistochemistry (IHC) was performed on large-area tissue sections from 493 patients with GC and evaluated using the HScore. GCs with moderate and strong FGFR2 expression were studied for Fgfr2 amplification using chromogenic in situ hybridization (CISH). Median overall survival was determined using the Kaplan–Meier method. The majority [240 (99.1%)] of FGFR2-positive GCs showed a variable combination of staining intensities with marked intratumoral heterogeneity, including weak [198 (40.2%) cases], moderate [145 (29.4%)], and strong [108 (21.9%)] staining in diverse combinations. 250 (50.9%) GCs expressed no FGFR2. Fgfr2 gene amplification was found in 40% of selected cases with high protein expression and was also heterogeneous at the cell level. FGFR2 protein expression did not correlate with patient survival in the entire cohort However, using different cutoff values, a negative correlation between FGFR2-expression and patient outcome was found for diffuse-type GC. FGFR2 expression was associated with a lower tumor grade and intestinal phenotype (p≤0.0001). FGFR2–positive diffuse-type GCs classify a small subset of patients with a poor tumor specific survival (5.29±1.3 vs. 14.67±1.9 months; p = 0.004).
To vax or not to vax: Predictors of anti-vax attitudes and COVID-19 vaccine hesitancy prior to widespread vaccine availability
Authors: Roberts Hannah A. , Clark D. Angus , Kalina Claire , Sherman Carter , Brislin Sarah , Heitzeg Mary M. , Hicks Brian M.
Published: February 2022

The novel coronavirus (COVID-19) is a highly contagious disease responsible for millions of deaths worldwide. Effective vaccines against COVID-19 are now available, however, an extreme form of vaccine hesitancy known as anti-vax attitudes challenge vaccine acceptance and distribution efforts. To understand these anti-vax attitudes and their associated psychological characteristics, we examined several predictors of vaccine hesitancy for COVID-19 and anti-vax attitudes generally. We surveyed 1004 adults (M = 47.0 years, SD = 17.1 years, range 18–98 years) in September-October 2020 across the United States (51% female, 49% male; 76.5% White, 23.5% non-White), prior to widespread availability of the COVID-19 vaccines. Attitudes toward vaccinations were influenced by a variety of factors, especially political attitudes. We should therefore anticipate and attempt to mitigate these challenges to achieving widespread vaccination to reduce the spread of COVID-19 and other communicable diseases.
Physicochemical characterization and in vitro evaluation of the antioxidant and anticandidal activities of Moroccan propolis
Authors: Aboulghazi Abderrazak , Touzani Soumaya , Fadil Mouhcine , Lyoussi Badiaa
Published: February 2022

Background and Aim: Human mycotic infections are one of the major health problems worldwide. Prolonged use of antimycotic drugs has contributed to the development of resistance in pathogenic fungi. This study was conducted to examine antioxidant and anticandidal activities of Moroccan propolis.

Materials and Methods: Two ethanolic extracts of Moroccan propolis from the Fez-Meknes region were evaluated regarding the following physicochemical parameters: Yield, pH, total carbohydrates, total proteins, total lipids, minerals, total phenolic content, total flavonoid content, and antioxidant activity using ferric reducing antioxidant power (FRAP) and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays. In addition, we assessed the in vitro anticandidal activity against vulvovaginal candidiasis strains, that is, Candida albicans, Candida glabrata, Candida parapsilosis, and Candida krusei, using the broth micromethod according to the CLSI/M27-A3 reference guidelines.

Results: The propolis samples exhibited a mean yield of 16%, with an acidic pH ranging from 4.8 to 5.9; the sample from the Oued Amlil area (OAPEE) contained high levels of resin, balsam, moisture, total carbohydrates, and total lipids: 59.8%, 0.71%, 2%, 1.01 gGlcEq/g, and 120 mg/g, respectively. Moreover, the sample from the Sefrou area (SFPEE) was richer in total proteins and minerals, with values of 2.5 g/100 g and 1.84%, respectively. The total polyphenol and flavonoid content in the propolis extracts were 117.38 and 194.68 mg of gallic acid equivalent/g, and 17.45–27.79 mg of quercetin equivalent/g, respectively. Regarding the antioxidant activity, the most effective propolis extract was the sample from the Sefrou area, at 72.5 μg/mL and 118.78 μmoL Fe2+/g for ABTS-half-maximal inhibitory concentration and FRAP-half maximal effective concentration, respectively. The analysis of phenolic compounds using high-performance liquid chromatography with a diode-array detector revealed the presence of 13 polyphenols. The main compound in the OAPEE sample was epicatechin (310 mg/g), whereas in the SFPEE sample was apigenin (410 mg/g). Regarding the antifungal activity against Candida species, the minimum inhibitory concentration and minimum fungicidal concentration of the Moroccan propolis ethanolic extracts ranged between 31.2 and 62.5 μg/mL and 62.5 and 125 μg/mL, respectively, comparable with fluconazole (as a reference antimycotic).

Conclusion: This study suggests that Moroccan propolis (31.2 and 125 μg/mL) may be an important source of bioactive molecules with anticandidal activity. Propolis may be a promising naturally-occurring candidate for the development of antimycotic drugs.
ITINERARIES BEYOND TOURISM: experiences with a local community in Petrolândia-PE
Authors: Lacerda Paulo Henrique Ferreira , Freitas Ranieryson Viana de , Kiyotani Ilana Barreto
Published: February 2022

The involvement of the local community is one of the main bases of support for the tourist development of localities, especially for small municipalities, where the lack of engagement of the population may be more keenly felt. One such case is Petrolândia, a small municipality in the sertão (semi-arid mountain range) of Pernambuco, where tourism is on the increase, but where attempts to raise awareness of tourism among the local community have been ineffective. In an action carried out with the municipal government, this work describes the experience of a pilot project applied in the community to promote the appreciation of the local culture and generate knowledge through tourism. The methodologies adopted by the pilot project involved tourist trips to local attractions and the application of questionnaires to the participants. The results, based on a qualitative approach, show that the action contributed to tourist awareness and helped strengthen relations between the local community and tourism. The action can also be an alternative for the municipal public planning of tourism and a tool for heritage education and tourist awareness.
Mobility and Integration in Hungarian Society
Authors: Szászvai-Papp Gábor
Published: February 2022

Review of "Mobility and Integration in Hungarian Society", edited by Imre Kovách (Centre for Social Sciences-Argumentum, 2020).
Agilitás a kis magyar informatikai vállalkozásokban a COVID-19 idején
Authors: Olasz Nikolett
Published: February 2022

A COVID-19 következtében megváltozott a világ működése, az együttműködési keretek és módok. A koronavírus bebizonyította, hogy minden szervezetnek képesnek kell lennie a nagyobb, előre nem látható zavarok és a környezeti változások, a bizonytalanságok kezelésére. A nemzetközi szakirodalomban több kutatás vizsgálta, hogy a COVID-19 milyen hatással volt az agilisan működő szervezetekre, illetve több tanulmány is arra mutat rá, hogy az agilitás nagyon hasznos megoldás volt számos COVID-19 válságot átvészelő szervezet számára, mivel az agilis csapatok, illetve szervezetek hosszú távon tudtak építkezni a dinamikusan változó turbulens környezetben is. A hazai szakirodalomban azonban nem esik szó arról, hogy a vírust megelőzően az otthoni távmunkavégzést kevésbé alkalmazó, agilisan működő kis szoftverfejlesztő cégekre, csapatokra milyen hatással voltak a COVID-19 által generált változások és milyen módon válaszoltak e változásokra a szervezetek. Jelen tanulmány elsősorban ezekre a kérdésekre keresi a választ és szeretné pótolni ezt a szakirodalmi űrt.
Neonatal Intestinal Obstruction Due to Kaposiform Hemangioendothelioma of the Jejunum
Authors: Maddileti Varunkumar , Mammen Abraham , Kuruvilla Shalini
Published: February 2022

Kaposiform hemangioendothelioma is a borderline vascular tumor usually seen in infants and children as cutaneous lesions classically associated with the Kasabach-Merritt phenomenon. Intestinal involvement is uncommon and can cause acute presentations, such as obstruction or gastrointestinal bleeding. A 5-day-old neonate presented with bilious vomiting for 2 days. The tumor was in the jejunum. Histopathological examination with immunohistochemistry of the resected jejunum showed CD34 positive endothelial lined vascular spaces infiltrating from submucosa to serosa, which is classical of kaposiform hemangioendothelioma. There was no deranged coagulation profile. This case forms an interesting cause for neonatal intestinal obstruction.
Intraepithelial and lamina propria lymphocytes do not correlate with symptoms or exposures in microscopic colitis
Authors: Sandler Robert S. , Hansen Jonathan J. , Peery Anne F. , Woosley John T. , Galanko Joseph A. , Keku Temitope O.
Published: February 2022

BACKGROUND:

Microscopic colitis, a common cause of diarrhea, is characterized by a largely normal appearance of the mucosa but increased numbers of lymphocytes in the epithelium and lamina propria on microscopy. We sought to determine whether T cell percentage was associated with exposures or symptoms.

METHODS

We conducted a case-control study that enrolled patients referred for colonoscopy for diarrhea. Patients were classified as microscopic colitis cases or controls by an experienced pathologist. Participants provided information on symptoms and exposures during a telephone or internet survey. Research biopsies from the ascending and descending colon were examined using immunofluorescence stains for CD3, CD8, and FOXP3 to determine percent T cells per total epithelial or lamina propria cells. Digital images were analyzed by region of interest using Tissue Studio.

RESULTS

There were 97 microscopic colitis cases and 165 diarrhea controls. There was no association between demographic factors and percentage of intraepithelial or lamina propria T cells. In cases, the mean percent T cells was similar in the right and left colon. There was no association between mean percent T cells and stool frequency or consistency. There was no association with irritable bowel syndrome, abdominal pain, or medications purported to cause microscopic colitis.

CONCLUSION

The lack of association between the density of T cells and medications raises further doubts about their role in disease etiology. Loose and frequent stools in patients with microscopic colitis are not correlated with T-cell density.
Programas de intervención psicosocial para el manejo del estrés en adultos migrantes de Latinoamérica: una revisión sistemática y meta-análisis
Authors:   Universidad Autónoma de Ciudad Juárez, México, Hernández Alvarado José Leonel , Ochoa Meza Gerardo ,   Universidad Autónoma de Ciudad Juárez, México, Gutiérrez Vega Marisela ,   Universidad Autónoma de Ciudad Juárez, México
Published: February 2022

Introducción: Las personas migrantes de origen latinoamericano atraviesan distintas fuentes de vulnerabilidad y una continua exposición al estrés durante sus recorridos hacia Estados Unidos, en congruencia con ello se han desarrollado programas de intervención para disminuir el desarrollo de trastornos psicológicos en población migrante. Método: Se realizó una revisión sistemática con meta-análisis siguiendo los lineamientos Cochrane y Prisma, determinando los siguientes componentes: población de interés, características de las intervenciones, criterios de comparación, resultados y diseños de intervención para conocer el contenido y eficacia en programas de intervención psicosocial en estrés dirigidos a adultos migrantes de origen latinoamericano en Estados Unidos. Resultados: Se identificaron 296 artículos en las bases de datos: EBSCO host, Science Direct, PubMed, Elsevier y el metabuscador Cochrane, siete de ellos fueron incluidos en la revisión sistemática y seis en el meta-análisis. Los resultados del meta-análisis señalan que los programas de intervención en estrés para adultos migrantes de origen latinoamericano realizados en Estados Unidos obtuvieron un tamaño de efecto bajo de .17, una variabilidad de 98.51 % y una heterogeneidad significativa. Conclusiones: Se detectaron discrepancias entre el tamaño de efecto reportado en los estudios primarios y lo valorado mediante el paquete metafor del programa estadístico Rstudio, además se encontraron serias limitaciones en los diseños y métodos empleados en los estudios primarios, lo cual restringe el alcance de los resultados encontrados en el presente estudio.
Enhanced Performance of Polylactide Film via Simultaneous Biaxial Stretching and Silane Coupling Agent as a Thermal Shrinkable Film
Authors: Phongtamrug Suttinun , Makhon Rommaneeya , Wiriyosuttikul Thanapa
Published: February 2022

Biaxial stretching technique has been known to improve the toughness of polylactide (PLA) film. Furthermore, blending with an additive is another way to control the mechanical properties of the product. The integrated effect of simultaneous biaxial stretching and blending with silane coupling agent on the properties of PLA film is examined in this study. The PLA pellets are melt compounded with various amounts of 3-aminopropyltriethoxy silane (APS). Then, the films are prepared by cast film extrusion and simultaneous biaxial stretching process with a stretching speed of 75 mm s–1. The relationships among the crystallinity, tensile properties, and thermal shrinkage of the prepared films are investigated. The crystallinity of PLA is significantly induced in the film by the stretching technique. An increase in the additive content also facilitates the polymeric crystallinity. The elongation at the break of the biaxially stretched film increases with the additive content, which corresponds with the PLA crystallinity. Compared to the pristine PLA film, the addition of 1% APS improves tensile strength in a transverse direction of the film about 10 times. The thermal shrinkage of the obtained films was evaluated to assess their applications as heat-shrinkable films. The prepared films show a thermal shrinkage of 45%, which are comparable to that of a commercial shrink film.
Pelatihan Keamanan Pangan di SMA Muhammadiyah Mlati, Kecamatan Mlati, Kabupaten Sleman, Propinsi D.I Yogyakarta
Authors: Aryani Titin , Shafriani Nazula Rahma
Published: February 2022

SMA Muhammadiyah Mlati adalah sekolah menengah atas swasta yang berlokasi di Jl. Magelang Km.7 Jombor, Sinduadi, Mlati. Jumlah siswa di SMA Muhammadiyah Mlati yaitu 35 siswa dari kelas X sampai kelas XII, jumlah guru dan karyawan yaitu 20 orang. Saat ini permasalahan terkait dengan konsumsi makanan yang mengandung bahan berbahaya tidak hanya terjadi di masyarakat, tetapi di lingkungan sekolah. Mitra pengabdian kepada masyarakat (PkM) adalah seluruh warga SMA Muhammadiyah, Mlati, Sleman, Yogyakarta dengan jumlah peserta sebanyak 27 orang. Tujuan pengabdianadalah memberikan penyuluhan kesehatan terkait kemanan pangan SMA Muhammadiyah, Mlati, Sleman Yogyakarta. Metode Pelaksanaan kegiatan meliputi kegiatan survey, koordinasi dengan mitra, penyusunan modul penyuluhan dan pelatihan, penyuluhan dan pelatihan terkait informasi keamanan pangan, penyuluhan dan pelatihan pengenalan Bahan Tambahan Pangan (BTP), praktek pengenalan bahan tambahan pangan, serta monitoring dan evaluasi kegiatan pengabdian kepada masyarakat. Hasil pengabdian kepada masyarakat dalam pelatihan kemanan pangan ini menunjukkan bahwa hasil post-test terhadap pesertakegiatan penyuluhan keamanan pangan mengalami peningkatan dibandingkan hasil pre-test. Adapun hasil pre-test sebelum pelatihan adalah 4,53 dan hasil post-test setelah pelatihan adalah 6,78. Kesimpulan dari kegiatan pengabdian kepada masyarakat yang dilakukan adalah terjadi peningkatan pengetahuan dan ketrampilan mitra sebanyak 23,32 % dalam pemahaman terhadap keamanan pangan dan bahan tambahan pangan.
IbDM tentang Literasi Media bagi Pemilih Perempuan Jelang Pemilu Langsung 2019
Authors: Anggraini Oktiva
Published: February 2022

Kegiatan pengabdian pada masyarakat ini ditawarkan sebagai solusi akan minimnya akses teknologi informasi serta rendahnya pemahaman pada persoalan hoax dan info pemilu 2019.  Hal ini berawal dari kondisi pre survey pengabdi bahwa di lokasi desa mitra, yakni di kecamatan Umbulharjo. Menjelang pemilu langsung Presiden tahun 2019,  sebagai salah satu kecamatan terbesar kota Yogyakarta, Umbulharjo tak luput dari sasaran fenomena hoax. Pemilih perempuan mudah dipengaruhi secara emosional. Di samping itu, rata-rata perempuan memiliki  pendidikan lebih rendah dari laki-laki, akses terhadap infromasi politik pun lebih  rendah. Mengingat lebih seringnya emosi yang mendominasi sehingga perempuan sering tidak sadar untuk menahan diri menyebarkan hoax. Berdasarkan latar belakang tersebut, hal yang menarik persoalan yang dijumpai di lokasi mitra: kurangnya pemahaman politik perempuan, hoax sulit ditangkal oleh masyarakat dan  kurangnya kesadaran warga untuk menahan diri menyebarkan hoax tanpa sadar. Berangkat dari akar permasalahan tersebut,  tim IbDM UWMY menawarkan solusi berupa literasi media yang sejalan dengan keseriusan pemerintah untuk menciptakan situasi politik yang kondusif jelang pemilu langsung Presiden Indonesia tahun 2019. Pendekatan yang dilakukan pada program aksi yakni Model Partisipatory Rural Appraisal (PRA), dengan teknik penyuluhan dan praktek.Digiatkannya gerakan literasi digital menjadi penting sebagai upaya menyadarkan masyarakat tentang peningkatan penguasaan teknologi digital dan alat komunikasi untuk mengakses, menerima, menganalisis dan mengevaluasi informasi dengan efektif. Dengan Gerakan Literasi Digital ini, masyarakat dilatih untuk mengoptimalkan kebaikan bermedsos, mengakses informasi yang positif serta mengajak masyarakat bersikap kritis dalam menerima informasi.
Peningkatan Jiwa Wirausaha Bagi Masyarakat Eks Pengungsi Timor-Timor di Desa Sukabitetek (Leontelu) Kecamatan Raimanuk Kabupaten Belu Nusa Tenggara Timor
Authors: Krisdiyanto Didik
Published: February 2022

Desa Sukabitetek (Leountelu) Kecamatan Raimanuk Kabupaten Belu merupakan salah satu desa di Kabupaten Belu yang berbatasan langsung dengan Republik Democratic Timoer Leste (RDTL). Desa Sukabitetek (Leontelu) atau Kamp Pengunngsian LP3T menampung sekitar 50 KK eks pengungsi Timor Leste yang menempati lahan Departemen Pertanian. Terdapat beberapa sumber daya yang bisa dimanfaatkan yakni ketersediaaan tenaga kerja, rendahnya harga buah kelapa, limbah produksi UKM kayu. Oleh karena itu dibutuhkan adanya pelatihan dan pendampingan kewirausahhaan pemanfaatan sumber daya tersebut. Metodologi yang digunakan adalah pra pelaksanaan pelatihan dengan melakukan Focus Group Discussion dengan masyarakat, pelaksanaan pelatihan dan pasca pelatihan dengan melakukaan analisa berdasarkan posttest. Berdasarkan survei pelatihan penanaman jiwa kewiarusahaan dapat diketahui bahwa 60% responden dapat menjawab dengan tepat pertanyaan terutama mengenaai konsep kewirausahaan yakni: sumber ide pembuatan usaha (90%,) memotivasi wirausahawan (87%), definisi minat/hobi yang dapat digunakan dalam sumber ide usaha (80%,) definisi sumber daya sebagai sumber wirausaha (80%), definisi produk baru (80%) dan hal-hal yang dibutuhkan dalam menjalankan usaha (70%).
ANALISIS STRATEGI DIGITAL MARKETING PRODUK INDUSTRI KREATIF DI KECAMATAN RAJAPOLAH, TASIKMALAYA
Authors: Risdiana Aris
Published: February 2022

Kecamatan Rajapolah memiliki potensi produk industri kreatif yang melimpah. Namun potensi ini belum sepenuhnya dapat diberdayakan. Pasalnya, para perajin masih kesulitan untuk menjual produknya. Oleh karena itu, diperlukan strategi pemasaran yang termanajerial dengan baik, sehingga harapannya dapat menghasilkan income yang signifikan bagi para perajin. Berdasarkan hal tersebut, UIN Sunan Kalijaga Yogyakarta sebagai lembaga yang bergerak dalam bidang pengembangan ilmu pengetahuan menjadikan kecamatan Rajapolah sebagai laboratorium sosial-ekonomi. Dengan memberikan pelatihan dan pendampingan digital marketing yang tujuannya sebagai strategi meningkatkan signifikasi pemasaran produk dari industri kreatif di kecamatan Rajapolah. Adapun program kerja UIN Sunan Kalijaga yang dilaksanakan berupa pelatihan, dengan tahapan sebagai berikut: (1) tahap persiapan, (2) tahap pelaksanaan proses dan (3) tahap pemandirian. Kegiatan program kerja ini dilaksanakan pada bulan Juli – Agustus 2019 yaitu berupa kegiatan: pendidikan dan pelatihan digital marketing. Beberapa manfaat praktis yang diharapkan dari pelaksanaan program kerja ini, antara lain: (1) masyarakat mendapatkan informasi yang utuh dan jelas tentang hakekat digital marketing sebagai strategi pemasaran yang efektif; (2) para perajin dapat menyusun strategi digital marketing untuk produk industri kreatif melalui pemanfaatan media sosial dan digital; (3) masyarakat dapat mengakses peluang-peluang pengembangan usaha mereka melalui digital marketing yang dapat mendatangkan nilai finansial. Dengan demikian, penelitian ini merupakan penelitian kualitatif yang berusaha menganalisis strategi digital marketing dengan fokus pada program yang dimotori dan dibimbing secara langsung oleh UIN Sunan Kalijaga dalam kaitannya untuk meningkatkan kualitas produk dan pemanfaatan digital marketing oleh masyarakat desa di era revolusi industri 4.0 yang berdasar pada community based research (CBR).diharapkan dari pelaksanaan program kerja ini, antara lain: (1) masyarakat mendapatkan informasi yang utuh dan jelas tentang hakekat digital marketing sebagai strategi pemasaran yang efektif; (2) para perajin dapat menyusun strategi digital marketing untuk produk industri kreatif melalui pemanfaatan media sosial dan digital; (3) masyarakat dapat mengakses peluang-peluang pengembangan usaha mereka melalui digital marketing yang dapat mendatangkan nilai finansial. Dengan demikian, penelitian ini merupakan penelitian kualitatif yang berusaha menganalisis strategi digital marketing dengan fokus pada program yang dimotori dan dibimbing secara langsung oleh UIN Sunan Kalijaga dalam kaitannya untuk meningkatkan kualitas produk dan pemanfaatan digital marketing oleh masyarakat desa di era revolusi industri 4.0 yang berdasar pada community based research (CBR).
ANALISIS PEMAHAMAN DAN KESIAPSIAGAAN INDIVIDU/RUMAH TANGGA MENGHADAPI BENCANA TANAH LONGSOR DI KECAMATAN KOKAP KABUPATEN KULON PROGO DIY
Authors: Krisdiyanto Didik
Published: February 2022

Pemetaan Risiko Bencana merupakan kajian yang paling banyak dilakukan dengan mengkaji tingkat ancaman bencana terhadap suatu wilayah tertentu melalui peta bencana. Untuk melengkapai suatu peta bencana perlu pula dikaji kemampuan suatu wilayah dalam merespon suatu bencana dalam bentuk kapasistas wilayah atau masyarakat. Untuk mempelajari itu dilakukan tahapan : identifikasi dan analisis pemahaman masyarakat, pelatihan bencana dan pengukuran kesiapsiagaan masayarakat selaku individu dan pemerintah desa. Hasil analisa menunjukkan bahwa secara umum masyarakat selaku individu telah memiliki gambaran pemahaman mengenai bencana tanah longsor, penyebab, ciri-ciri daerah yang rawan longsor dan sumber informasi daerah rawan tanah longsor dan informasi keadaan sudah aman. Akan tetapi pemahaman dan kesiapsiagaan masyarakat selaku individu masih perlu ditingkatkan untuk penyelamatan dan evakuasi keluarga saat terjadi bencana longsor. Perlu ditingkatkan pemahaman dan tindakan yang harus dilakukan saat bencana longsor, tindakan setelah longsor terjadi, latihan ketrampilan anggota keluarga dan aset yang harus dimiliki sebagai antisipasi bencana
PERENCANAAN URBAN GREEN SPACE DALAM MERESPON COVID-19
Authors: Nadlifah Hindun
Published: February 2022

Bendosari Eduwisata Fruit Garden is a natural laboratory assisted by the Center for Development and Community Service, a work unit under the auspices of the Research and Community Service Institute (LPPM) of UIN Sunan Kalijaga Yogyakarta. This research is a guide in the further development of the master plan for the Bendosari Eduwisata Fruit Garden in the design development phase, before entering the final phase, namely the final master plan in the form of construction documents. The methodology used is descriptive qualitative research method. The initial stage is carried out by conducting interviews and focus group discussions with garden managers and the surrounding community. Then proceed with conducting a site analysis and study of precedents. Based on the collected data, a schematic master plan is then designed which is composed of site analysis and programming, adjusting to the needs and surrounding conditions. The Bendosari area is prepared to become an urban green space area that is resilient or able to withstand any situation such as the current Covid-19 pandemic. This design focuses on community empowerment through a participatory approach and learning together which aims to prosper the community around the orchard area, both in terms of economy and environmental health.
Moderasi Relasi Lintas Agama Tau Samawa (Orang Sumbawa) Berbasis Keseharian di Tana Sumbawa
Authors: Funay Yaspis Edgar
Published: February 2022

This paper will analyze the interfaith relations based on people’s daily life patterns in Tana Sumbawa. Deeper, the author tries to see how a cultural-based lifestyle in society can also be one of the strengths and the closest way out to maintain community relations when they want to conflict or create post-conflict reconciliation. This paper draws a tentative conclusion that the original culture of the Sumbawa people can be a reconciliation of ideological conflicts and strengthen collective awareness because they have ethical values, morals, and good behavior as local products. Using a sociological perspective this paper examines the extent to which cultural values play a role in interfaith relations in Sumbawa. In the final part, this paper will explore the concept of Sumbawa culture as outlined in local philosophy as a concept of tolerance between religious communities in order to maintain the existence of the local cultural heritage.
Deradikalisasi Kaum Remaja dalam Membendung Radikalisme Media Sosial
Authors: Mutrofin Mutrofin , Kharis Ahmad
Published: February 2022

The emergence of information media has resulted in a massive revolution in the pattern of relations between people as individuals and groups. This changes the information media as a realm of upheaval in the propaganda community that has an interest, including as a propagator of radical ideology. Deradicalization program as a strategic action which is based on conceptual understanding to deal with issues related to the development of ideologies and axis of radicalism is very important to be implemented in adolescents in this millennial era. Through this paper the author wants to discuss efforts to counter radicalism activities among adolescents, especially on social media platforms. By examining issues related to the latest radicalism and analyzing literature literacy. The author hopes this article can be useful for deterring radicalism activities, especially on social media.