bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALISIS PEMASARAN USAHA KERIPIK SUKUN “DUA PUTRI” DI DESA BARU KECAMATAN MANGGAR KABUPATEN BELITUNG TIMUR
Authors: Yulia  , Putra Boby Arya
Published: October 2023

Keripik sukun merupakan salah satu usaha yang cukup diminati. Keripik sukun memiliki cita rasa yang nikmat. Konsumen keripik sukun semakin meningkat seiring meningkatnya variasi rasa dan olahan buah sukun. Tujuan dari penelitian ini yaitu mengetahui saluran pemasaran yang diterapkan pada UMKM “Dua Putri”, merumuskan strategi dan kendala kreasi-pemasaran kreasi keripik sukun. Adapun metode yang digunakan dalam penelitian ini yaitu metode survei. Analisis data menggunakan metode deskriptif kualitatif dengan analisis SWOT. Hasil penelitian menunjukkan bahwa saluran pemasaran yaitu saluran pemasaran nol tingkat dan saluran pemasaran 1 tingkat. Strategi yang dapat diterapkan yakni mempertahankan hubungan antar karyawan, mempertahankan kualitas bahan dasar, mempertahankan kualitas kreasi, meningkatkan SDM guna menghasilkan kreasi berkualitas, menyediakan mesin kasir, meningkatkan citarasa kreasi, menyediakan lebih banyak sarana promosi, menciptakan inovasi kreasi, meningkatkan promosi dan melakukan inovasi dalam pemasaran. Kendala yang dihadapi oleh UMKM “Dua Putri” yaitu kompetisi dalam  kreasi yang sama, kompetisi dalam  harga, harga dan ketersediaan bahan dasar yang tidak stabil, serta SDM yang rendah.
PEMBENTUKAN KARAKTER KEWIRAUSAHAAN DENGAN KEGIATAN MARKET DAY DI SEKOLAH DASAR SOEKARNO HATTA
Authors: Badawi Badawi Badawi
Published: October 2023

The character of students must be able to reflect the culture of the Indonesian nation. The formation of character is very important in the world of education. Education must play a role in forming character in the transformation of knowledge so that Indonesian people are knowledgeable and have character. This study aims to describe the implementation of market day in the formation of entrepreneurial character in students at Soekarno Hatta Elementary School. The methodology in research on the formation of entrepreneurial character through market day activities at Soekarno Hatta Elementary School uses descriptive qualitative methods. This method attempts to describe the phenomena that occur in character building through market day activities. The subjects in this study were teachers and students of Soekarno Hatta Elementary School located at Soekarno Hatta Elementary School, Kotabumi, North Lampung. Data collection was carried out by first observing and semi-structured interviews. Data analysis techniques used data reduction and data triangulation. The results showed that market day activities were activities for forming students' entrepreneurial character values. Entrepreneurial character values ​​formed through market day activities at SD Soekarno Hatta are honest, creative, innovative, disciplined, cooperative, responsible, independent and confident. Entrepreneurial character values ​​can be formed from market day activities in the concept of character education, namely exercise of the heart, exercise of thought, exercise of taste, and exercise.
Internalisasi Nilai Religius pada Novel Bidadari Berbisik Karya Asma Nadia di Sekolah Menengah Atas
Authors: Ratnaningsih Dewi , Widayati Sri , Susanti Alfina
Published: October 2023

Internalization is an effort to instill values ​​and norms into a person. The internalization of religious values ​​in the novel Whispering Angel by Asma Nadia in high school is an interesting study to do. The purpose of this study is to describe the internalization of religious values ​​contained in Asma Nadia's novel Whispering Bidadari and describe the learning plan for internalizing religious values ​​contained in Asma Nadia's Whispering Bidadari novel in high school. The method used in this research is descriptive method with a qualitative approach. The results of the study show that there is a religious value in the Whispering Angel novel, namely 1) the relationship between humans and God, 2) the relationship between humans and oneself, 3) the relationship between humans and other humans, and 4) the relationship between humans and nature. Based on the results of the study, religious values ​​in the novel Whispering Angel by Asma Nadia can be internalized to high school students. Teachers can internalize the religious values ​​contained in the novel into students by designing learning competencies and objectives, learning materials or materials, methods, strategies, and learning evaluations. Then, the teacher carries out the learning steps which consist of opening, learning core, and closing.
Nilai Sosial dalam Kumpulan Cerpen Trilogi Alina Karya Seno Gumira Ajidarma dan Rancangan Pembelajaran Bahasa Indonesia di SMA
Authors: Prasetyo Heru , Pertiwi Annisa Diah , Riadi Bambang , Munaris
Published: October 2023

Abstract:

This study aims to describe the social values ​​of Seno Gumira Ajidarma's short story collection Trilogi Alina and its relation to the design of Indonesian language learning in high school. The method used in this research is descriptive qualitative.The data source of this research is the short story collection Trilogi Alina by Seno Gumira Ajidarma. The data in this study is qualitative data in the form of words, phrases, and sentences in short stories.The data in this study were collected through text content analysis techniques to describe data regarding social values ​​based on Zubaedi's opinion through Charles Sanders Peirce's semiotic approach with index limits. The results of the study show that the collection of short stories Trilogi Alina by Seno Gumira Ajidarma contains social values, namely caring, devotion, helping, loyalty, kinship, values ​​of belonging, discipline, empathy, justice, and cooperation. The results of this study can be used as a learning design for high school.

Penelitian ini bertujuan untuk mendeskripsikan niai-nilai sosial dalam kumpulan cerpen Trilogi Alina karya Seno Gumira Ajidarma dan kaitannya sebagai rancangan pembelajaran Bahasa Indonesia di SMA. Metode yang digunakan dalam penelitian ini, yaitu deskriptif kualitiatif. Sumber data yang digunakan, yaitu kumpulan cerpen Trilogi Alina karya Seno Gumira Ajidarma. Data dalam penelitian ini adalah data kualitatif berupa kata, frasa, maupun kalimat dalam cerpen. Data pada penelitian ini dikumpulkan melalui teknik analisis isi teks untuk mendeskripsikan data-data mengenai nilai-nilai sosial berdasarkan pendapat Zubaedi melalui pendekatan semiotika Charles Sanders Peirce dengan batasan indeks. Hasil penelitian menunjukkan bahwa dalam kumpulan cerpen Trilogi Alina karya Seno Gumira Ajidarma memuat nilai-nilai sosial, yaitu kepedulian, pengabdian, tolong menolong, kesetiaan, kekeluargaan, nilai rasa memiliki, disiplin, empati, keadilan, dan kerja sama. Hasil penelitian ini dapat dimanfaatkan sebagai rancagan pembelajaran untuk kelas XI SMA.
ANALISIS SEMIOTIKA TEORI ROLAND BARTHES DALAM PUISI “CINTA YANG AGUNG” KARYA KAHLIL GIBRAN
Authors: Prasetyo Heru
Published: October 2023

Penelitian ini bertujuan untuk mengkaji semiotika menggunakan teori Roland Barthes dalam salah satu puisi karya Kahlil Gibran berjudul “Cinta yang Agung”. Metode penelitian yang digunakan adalah pendekatan kualitatif dengan menggunakan analisis semiotik sebagai alat analisis. Puisi "Cinta yang Agung" dipilih sebagai objek penelitian karena mengandung makna yang dalam dan kompleks, serta melibatkan penggunaan tanda-tanda dalam membentuk makna dan pesan yang tersembunyi. Penelitian yang akan dibahas, yaitu mengenai lima kode Roland Barthes dan menganalisis setiap tanda yang terdapat dalam data. Hasil penelitian ini diharapkan dapat memberikan pemahaman yang lebih dalam tentang makna dan pesan yang terkandung dalam puisi "Cinta yang Agung" karya Kahlil Gibran melalui analisis semiotik Roland Barthes.Kata kunci: Kajian Semiotika, Roland Barthes, Puisi
Impact of Cash Transfers on Poverty Reduction towards Achieving Sustainable Development Goals among Female-Headed Households in Siaya County, Kenya.
Authors: Omondi Simona , Nyongesa Destaings , Odhiambo Scholastica
Published: October 2023

Poverty rate is still high among developing economies; 8 years post adoption of the Sustainable Development Goals (SDGs) agenda of 2030. Cash transfers have popularly become one of the ways to support implementation of SDGs. This study focused on the Inua Jamii-CT programme whose principal objective was to establish the impact of cash transfer on poverty reduction towards achieving SDGs among female-headed households in Siaya County. The study was founded on the Household Welfare Theory where household welfare is best measured in terms of income and consumption decisions of the household. The study targeted the 109,680 female-headed households in Siaya County. The Yamane formula arrived at a sample of 399 households. A correlational design was adopted and 377 respondents realized. An analysis of descriptive statistics of respondent household demographics revealed that 214 of the households receive cash transfers against 163 who don’t. The average household expenditure was on food and farm inputs. The female-head was averagely 49 years old, 52.2% were of good health and 85.7% had reached only primary level of education. The household had a mean of 5 members. 51.7% of the female-heads belonged to a social group. 41.4% of the female-head earned their income from farming and 36.3% from small businesses. A binary logit regression model determined that cash transfer, income, household consumption were significant predictors of SDGs among FHHs in Siaya County with P values of less than 0.05. The R2 of 0.3 showed a 30% goodness of fit for the model. The coefficients of cash transfer and income are β1=-0.935 and β2=- 0.689 respectively, hence, increasing cash transfers and income reduces poverty. There was a negligible relationship between household consumption and SDGs β3=0.0004. Conclusion was drawn that CT was significant in the achievement of the SDGs. The study recommends a targeted programme design to ensure more income generating activities and good farming practices.
The Dynamics of European Union Foreign Electoral Assistance: Case of Kenya’s General Elections
Authors: Kennedy Ogutu Reuben , Omondi Barack Calvince , Juma Thomas Otieno
Published: October 2023

Electoral integrity is widely recognized as an indispensable element of democratic consolidation in the developing world. However, achieving electoral integrity in these countries has been hindered, in part, by their deficient capacity to invest in the essential resources required to enable key sectors to fulfill their roles in ensuring free, fair, and credible elections. Additionally, elections in these regions often report malpractice characteristics such as electoral fraud, contested results, and protracted legal disputes over outcomes. Consequently, external actors have been called upon to help bridge these gaps, foster peaceful political transitions, and bolster the process of democratization. Despite substantial support from foreign actors, there is a paucity of research focusing on the dynamics of their involvement through technical and capacity-building initiatives. Existing research often presents passive assertions about specific African countries, leaving a dearth of empirical evidence regarding the extent and manner of external actors’ engagement in these nations. Consequently, fundamental questions concerning when, how, and to what effect external actors intervene in foreign electoral support efforts remain unanswered. This study investigates the European Union’s contribution in supporting democratization in Kenya through technical and capacity-building assistance. Employing a case study approach and interpretive descriptive designs, the research delves into the intricacies of EU electoral support in Kenya. By conducting purposive Key Informant Interviews with representatives from key stakeholder institutions and administering surveys to 384 respondents, this study discerns that foreign technical and capacity-building assistance primarily occurs during elections, despite EU policy documents emphasizing that elections are a process rather than a one-time event. The findings reveal that capacity building and technical support, while closely intertwined, are analytically distinct components of EU support, both delivered through the basket fund mechanism. This support is targeted at both governmental institutions involved in elections and non-governmental stakeholders. Crucially, the study establishes that the extent to which the EU’s support can contribute to free, fair, and credible elections hinges on the degree of “political hygiene” practiced by the political class and political parties. In essence, the effectiveness of EU support is profoundly influenced by the conduct of domestic political actors, highlighting the intricate interplay between foreign assistance and internal political dynamics. The theoretical framework is guided by Professor Michal Doyle’s Liberal Democratic Peace Theory.
The Seaweed Supply Chain in Jambiani Coastal Communities, Zanzibar:
Authors: Hamidu Kirumirah Mubarack , Issa Ibrahim Mohammed , Twenye Omary , Mlang'a John Selestini
Published: October 2023

The study investigates activities in the supply chain of seaweed and their challenges among seaweed farmers in the coastal community of Jambiani-Zanzibar. The study is conducted in Zanzibar's Jambiani area with greater concentration in Kikadini and Kibigija. Employing qualitative approaches, the case study design is chosen to be the best fit in to this study considering the case, respondents and nature of the study. Researchers recruit 45 respondents through snowball and purposive techniques. To obtain the required data, researchers make use of In-Depth Interviews (IDI), focus group Discussions (FGD) and document review. Through tables created manually, researchers code and analyse data content wise. Findings show that the supply chain of seaweed just like other crops involve activities like farming and harvesting, storage and preservation, value and quality addition well as marketing. However, seaweed farmers were confronted by challenges include low price, lack of proper storage facilities, farming and harvesting facilities, climatic changes among others. Thus, based on the observed findings, researchers recommend the establishment of well facilitated drying and storage centres, sufficing farmers with adequate information regarding seaweed market and prices worldwide and establishment of seaweed processing industries which will help in minimizing the act of selling raw seaweed abroad.
EFICÁCIA DO PLASMA RICO EM PLAQUETAS PARA O TRATAMENTO DE ALOPÉCIA ANDROGENÉTICA
Authors: Nakano Pereira Pedro , Rezende Corrêa Gabriela , Teixeira Gonçalves Isabela , Bertanha Suzana , Da Silva Fernandes Lais
Published: October 2023

A alopécia androgenética (AAG) é uma patologia dermatológica de caráter multifatorial, de origem poligênica, caracterizada pela alteração do ciclo capilar, levando a uma miniaturização folicular progressiva, que deixa os fios terminais mais finos e menos pigmentados. Objetivos: avaliar a eficácia e os efeitos colaterais do tratamento com plasma rico em plaquetas em pacientes portadores de AAG. Materiais e métodos: Trata-se de uma revisão integrativa, em que a questão norteadora foi “O plasma rico em plaquetas é eficaz no tratamento da alopécia androgenética?”. A busca pelos artigos ocorreu na base de dados PubMed a partir dos termos “efficacy”, “platelet-rich plasma”, “treatment” e “androgenetic alopecia”, combinados entre si pelo operador booleano AND. Resultados e discussão: Os resultados da pesquisa demonstraram que o PRP tem eficácia no tratamento da AAG, sem grandes efeitos colaterais. Dos 13 artigos analisados, 4 compararam a eficácia da terapia com o PRP em relação ao Minoxidil, sendo que um deles fez a análise das duas substâncias em terapia combinada. Os estudos comparativos entre o PRP e Minoxidil mostraram que ambos foram bem tolerados e eficazes. Uma meta-análise que buscou identificar a eficácia da monoterapia com PRP em homens e mulheres separadamente, avaliando a densidade e o diâmetro capilar, o PRP aumentou significativamente o diâmetro capilar em ambos os sexos, mas a densidade capilar foi significativamente aumentada somente nos sexo masculino. Conclusão: A maioria dos trabalhos analisados nesta revisão mostraram resultados positivos em ralação ao uso do PRP na AAG, tanto no sexo masculino como no feminino.
MISERLINESS AND ITS IMPACT ON SPENDING - AN ISLAMIC ECONOMIC VISION
Authors: Ahmed YASSIN Newroz
Published: October 2023

Miserliness is considered one of the economic, social and psychological vice behaviors, and it is a moral strike that leads to harm to man and society, and Islam has vigorously fought it through the provisions of the Holy Qur’an and what was reported from the Prophet Muhammad (PBUH), which stresses the necessity of spending as an economic, social and faith-based work that pervades Its benefit to society, and the spenders attain God’s pleasure (PBUH). The research was divided into five sections. The first topic dealt with the concept of miserliness, its causes, and its ruling. The second topic dealt with miserliness in the Holy Qur’an, while the third topic dealt with miserliness in the light of the Prophet’s Sunnah. As for the fourth topic, it focused on miserliness in Islamic thought, while the fifth topic dealt with the effects of miserliness. Miserliness in spending. The research ended with a conclusion and recommendations.
Tratamiento cuádruple con doxiciclina, furazolidona, bismuto e inhibidor de bomba de protones sigue siendo efectivo frente al Helicobacter pylori en nuestra población
Authors: Barreda-Costa Carlos S. , Piccini-Larco Julio R. , Chu-Revollar Lang Dai , Salazar-Muente Fernando , Barriga-Briceño José A. , Herrera-Alzamora Madeleine A.
Published: October 2023

Nuestro objetivo es determinar si el tratamiento para Helicobacter pylori (HP) con doxiciclina, furazolidona, bismuto y un inhibidor de bomba de protones mantiene su efectividad en nuestra población. Se realizó un estudio retrospectivo, no aleatorio, realizado en una clínica privada de Lima, Perú. Se obtuvo la información de la historia clínica digital. Se incluyó a pacientes con el diagnóstico de infección por HP por biopsia y/o test rápido de la ureasa, obtenidos al realizar una endoscopía entre enero 2017 a octubre 2022. Debían haber recibido el tratamiento cuádruple en estudio o un esquema triple alternativo con amoxicilina, levofloxacino e inhibidor de bomba de protones y tener una prueba de aliento para HP en el lapso de 1 a 6 meses después del tratamiento. El esquema cuádruple con furazolidona logró la erradicación en 117/122 casos (95,9%) mientras que el triple con levofloxacino en 5/16 (31,2%) cuando se usó por 7 dias y en 22/38 (57,9%) cuando se usó por 10 días, siendo las diferencias altamente significativas (p>0,001). En conclusión, el tratamiento cuádruple con furazolidona mostró alta efectividad, mientras que el triple con levofloxacino no alcanzó niveles aceptables.
Criterios 5-5-2 de canulación biliar y complicaciones post colangiopancreatografía retrógrada endoscópica: Experiencia en un hospital de referencia, Perú
Authors: Quiroga Purizaca Wilmer Gustavo , Páucar Aguilar Diego Ricardo , Barrientos Pérez Jackeline Amparo , Gutiérrez Córdova Isamar Benyi , Garrido Acedo Renato , Vargas Blácido Daniel Andrei
Published: October 2023

La Sociedad Europea de Endoscopia Gastrointestinal (ESGE) define “canulación difícil” como aquella en la que se realizan más de 5 intentos, se exceden 5 minutos, o se produce canulación inadvertida del conducto pancreático 2 o más veces (criterios 5-5-2), recomendando estos puntos de corte para realizar técnicas avanzadas de canulación y disminuir la tasa de eventos adversos post CPRE. Nuestro objetivo fue evaluar el rendimiento de los criterios 5-5-2 y su asociación con complicaciones post CPRE en un hospital de referencia de Perú. Realizamos un estudio analítico prospectivo de casos y controles en el que se incluyó 120 pacientes a los que se realizó CPRE. El grupo casos estuvo formado por 30 pacientes que cumplieron al menos uno de los criterios 5-5-2 y el grupo controles por 90 pacientes sin ninguno de estos criterios. Se comparó el desarrollo de complicaciones en cada grupo y su asociación con cada uno de los criterios 5-5-2. Las complicaciones presentadas fueron: pancreatitis post CPRE (6,6% en el grupo casos vs 3,3% en el grupo controles), sangrado (3,3% controles vs 0% casos) y perforación (1,1% controles vs 0 % casos); sin observar diferencia estadísticamente significativa. El criterio de 2 o más ingresos inadvertidos al conducto pancreático presentó asociación significativa (OR= 10,29, IC: 1,47-71,98; p= 0,005) con el desarrollo de pancreatitis post CPRE. Los criterios 5 minutos y 5 intentos no se asociaron a complicaciones post CPRE. En conclusión, el más relevante de los criterios 5-5-2 fue el ingreso inadvertido al conducto pancreático en 2 o más ocasiones, mostrando asociación por sí solo con pancreatitis s podrían ampliarse con cautela sin aumentar la tasa de complicaciones post CPRE.
Efecto regenerador gástrico del consumo de Petroselinum sativum L. (perejil) en ratas con gastritis inducida por etanol
Authors: Arrascue Navarro Betty Rosabeth , Troncoso-Corzo Luzmila Victoria
Published: October 2023

El objetivo del presente trabajo fue determinar el efecto regenerador gástrico del consumo de Petroselinum sativum L. (perejil) en ratas con gastritis inducida por etanol. Se realizó un estudio analítico, experimental clásico, transversal, prospectivo. Se trabajó con 36 ratas Wistar machos (250 ± 30 g.p.c.) distribuidas aleatoriamente en 6 grupos (n=6). Los grupos II-VI fueron sometidos a ayuno de 24 horas para inducirles úlcera gástrica administrándoles 10 mL/kg.p.c. de etanol al 70% vía orogástrica. Después de una hora, se procedió a sacrificar al grupo II para observar el daño ulceroso en el estómago. Después, se elaboró el extracto acuoso de hojas frescas de perejil (EAHP) y se administró a los demás grupos el siguiente tratamiento por vía orogástrica durante 3 días: grupo III, 10 mL/kg.p.c. de solución de NaCl al 0,9%; y EAHP a los grupos IV-VI (150, 300 y 600 mg/kg.p.c., respectivamente). Enseguida, las ratas fueron sometidas a ayuno de 24 horas para luego ser sacrificadas por desnucamiento. Posteriormente, se les realizó una laparotomía para la extracción del estómago. El EAHP generó mayor producción de moco gástrico en las dosis de 300 mg/kg.p.c. con 78,03% y de 600 mg/kg.p.c. con 80,52% (p<0,05). Esto concordó con lo observado histológicamente en la mucosa gástrica, mostrando solo signos de inflamación de la submucosa en los grupos que consumieron EAHP (IV-VI), en comparación con necrosis fibrinoide de los grupos que no lo c ieron (II y III). En conclusión, el consumo de EAHP tiene un efecto regenerador gástrico en ratas con gastritis inducida por etanol.
Clinical characteristics of early-onset gastric cancer. A study in a Colombian population
Authors: Mantilla Marta Juliana , Chaves Juan José , Ochoa-Vera Miguel , Africano Ferney , Parra-Medina Rafael , Tovar-Fierro German
Published: October 2023

Gastric cancer is a multifactorial disease with important genetic and environmental factors. It is the fifth most common cancer in incidence, and the fourth cause of death secondary to cancer. The incidence of early-onset gastric cancer is increasing worldwide, but clinical information on these patients has not been well established. We analyzed the association between age and clinical, endoscopic, and histopathological characteristics of gastric cancer at the time of diagnosis in a Latin American population. A retrospective and descriptive cross-sectional study was carried out using the database of the Gastroenterology Service of the Clínica Foscal and Clínica Foscal Internacional in Bucaramanga, Colombia. Between January 2016 and December 2019, 259 de novo gastric cancer cases were diagnosed, of which 36 patients (13.9%) were 40 years old or younger. In patients with early-onset gastric, the prevalence of gastric cancer diagnosis was lower in men. A family history of gastric cancer or any other neoplasm was not associated with a higher prevalence of gastric neoplasms. In young patients, vomiting and ascites were more common, the preferred anatomical location was the body of the stomach, and the Borrmann IV classification and thediffuse-type histology were more likely. Our study showed an approximation of the characteristics of early-onset gastric cancer in a Latin American population, where we observed that early-onset gastric cancer has different demographic, anatomical, and histological features than late-onset gastric cancer.
Hepatotoxicidad por tamsulosina / dutasterida: reporte de un caso probable
Authors: Yance Stalin , Montes Pedro
Published: October 2023

La tamsulosina y dutasterida son medicamentos ampliamente usados como tratamiento de la hipertrofia benigna de próstata. teniendo un buen perfil de seguridad. Existen escasos reportes de injuria hepática asociado al uso de tamsulosina; sin embargo, no hay reportes de toxicidad hepática por el uso de dutasterida y del uso combinado de tamsulosina/dutasterida. Se presenta el caso de un varón de 64 años quien desarrolla injuria hepática tras el uso combinado de tamsulosina/dutasterida, desarrollando un patrón de daño hepatocelular y clínica de hepatitis aguda. Se realizo descarte de patología hepática viral, autoinmune y enfermedades metabólicas de depósito, así como de patología biliar mediante ecografía abdominal y colangioresonancia. En la evaluación de causalidad, presentó CIOMS-RUCAM: 6 puntos (probable) y Naranjo: 4 puntos (posible). El paciente presentó respuesta clínica y laboratorial luego de suspender el medicamento.
Asociación entre la vitamina D y las enfermedades inflamatorias intestinales
Authors: Baz-López Alina , Barreiro-de-Acosta Manuel
Published: October 2023

La vitamina D es una hormona conocida desde larga fecha, por sus efectos sobre la salud ósea y la regulación del metabolismo del fósforo y calcio. Desde el descubrimiento de receptores para esta molécula en un gran número de células del organismo, se ha abierto el campo para el estudio de sus efectos sobre el sistema inmune. Sus relaciones con las células del sistema inmune, genes y microbiota hace que el interés sea grande en relación con enfermedades inmunomediadas. Muchos datos indican que esta vitamina tiene efectos preventivos, moduladores y controladores de los efectos adversos de las Enfermedades Inflamatorias Intestinales (EII) en la salud ósea, aunque es difícil demostrar la causalidad de forma taxativa. En esta revisión intentamos resumir la situación actual y los temas de controversia en este interesante campo, centrándonos en las enfermedades inflamatorias intestinales.
A Study on Human Moral Defects and Moral Education
Authors:   The K Association of Education Research, Jeong Cheol-Yeong
Published: October 2023

In human nature, good and evil exist together. Regarding human wickedness, the Old Testament keeps The God away from the human mind, and in the New Testament, there is also evil for me who wants to do good, so it is an incomplete mind that can do evil at any time. Characteristics close to human morality or evil can be relatively strong when the altruistic mind weakens. In order to overcome the moral flaws of human selfishness and proceed with wiser moral education, the moral flaws of concepts close to evil, moral flaws, unethical, unhuman, selfish, antisocial, poor defense mechanisms, and deviance should be revealed in more detail. Focusing on the philosophical and psychological perspectives on the area of human moral defects, this study presented moral defects in the use of defense mechanisms in the behavior of moral defects of lack of discernment, weakness of will, lack of duty, inferior function of moral preference, and rationalization. It also presented the skills of moral education in behavior modification and discipline measures that can overcome the error rationalization of behavior that students themselves give themselves by distinguishing students' moral defects and moral errors of self-immunity at a time when teacher education rights need to be reformed.
Analysis of the Relationship between PARP1 and BRCA1 Suggests PARP1 Gene Has a Role in Breast Cancer
Authors: Modi Kush , Joseph Tony
Published: October 2023

Poly [ADP-ribose] polymerase 1 (PARP1), one of the genes in the PARP family, is mainly involved in the detection and repair of DNA damage in cells, and its upregulation has been associated with tumorigenesis. PARP1 is essential to all cells in the body as it ensures that DNA is replicated correctly. The PARP1 protein addresses repair of single-stranded breaks (SSBs) in DNA by initially binding near the point of break in the DNA. While it is bound to the region of the SSB, PARP1 transfers ADP ribosyl moiety from NAD+ to acceptor proteins. This leads to the recruitment of DNA repair proteins to the region of DNA breaks. The PARP1 protein also aids the double-stranded break (DSB) repair of DNA by recruiting the homologous recombination (HR) pathway proteins. Due to this role of PARP1 in DNA repair, it has been associated with cancer growth. Using databases, including UniProt, Xena Browser, and CBioPortal, this article explores the relationship between PARP1 mutations and BRCA1-mutated breast cancer. BRCA1 is a tumor suppressor gene, which is involved in DNA repair through the HR pathway. Therefore, in BRCA1-mutated cells, the lack of tumor suppressor factors leads to cancer growth. However, in a cell that has both BRCA1 mutations and PARP1 inhibition, DNA damage cannot be repaired, leading to apoptosis. Hence, PARP1 inhibitors have become essential in BRCA1-mutated breast cancers. There are several PARP1 inhibitors that are currently being used to treat breast cancer, which work using several mechanisms of action, including PARP1 trapping, which prevents the repair, transcription, and replication of DNA. This article also focuses on the clinical trials of three specific drugs, Olaparib, Iniparib, and Veliparib, which are used to treat breast cancer. However, due to the lack of understanding surrounding PARP1 inhibition mechanisms and potential drug combinations, more research needs to be done to understand potential biomarker targets and PARP1 inhibitor resistance.
Loneliness & College Students: A Needs Assessment Regarding Georgetown Student Experiences in a Post-Virtual World
Authors: Lyons Kelsey , Magsayo Marcus , Maheshwari Riya
Published: October 2023

The educational adjustments to the COVID-19 pandemic (e.g., distance learning and Zoom) have led to instances of loneliness and isolation among college students, especially at residential campuses such as Georgetown University. Such social disengagement can have a significant impact on a student’s transition to campus and can have a lasting effect on the rest of their college life. This needs assessment (performed in the Spring of 2022) explores the impact of loneliness among students, including themes such as mental health issues, loss of campus engagement, and problems with relationship-building. Pre-pandemic data on the social experiences of high-risk populations on college campuses are included to highlight how the post-virtual environment may have exacerbated varying pre-existing levels of loneliness. This data provides background for the needs assessment of the post-virtual world, as the core focus of this paper is solely post-virtual education/post-pandemic student experiences. We hypothesized that student and faculty interviews conducted at Georgetown University, and scholarly analysis of literature, would indicate the need for improved social support in the college setting. Students reported a lack of connection and increased mental health challenges due to the virtual environment of education during the COVID-19 pandemic. From the research, we determined that an app to address student loneliness (Nod), opportunities to engage with faculty, spaces of well-being on campus, and quality and accessible mental health resources are recommended to combat student loneliness. The negative impacts of the pandemic are still affecting college students today. Thus, it is necessary to identify ways to mitigate increased loneliness and isolation.
Impact of Participative Leadership on Employee Retention Mediating Role of Co-workers and Supervisors Relationship
Authors: Rajani Sandhia
Published: October 2023

The relationship between the leaders and subordinates plays a crucial role in a leaving or staying in the organization. This study will assess the impact of participative leadership, Supervisor relationships, and Co-workers on Employee retention. The mediation effect of Supervisor relations and Co-worker relationships is to be checked. This research study focuses on the banking sector and follows explanatory research using a quantitative method to investigate the core reason/issues that occurred between the supervisor and co-worker relationship and the role of higher management to create a positive relationship between them. Hayes process was used for data analysis. Sample size was 250 and the Convenience sampling method was applied. An online survey of questionnaire was conducted for data collection. Results shows that Participative Leadership, Supervisor relationship have a significant effect on Employee retention whereas Participative leader affects Co-worker relationship and Supervisor relationship. However, Co-worker relationship impact is insignificant on Employee retention. The mediation effect of Supervisor relationship is significant, and Co-worker is insignificant.
O que representa e quais são os efeitos advindos de condição resolutiva aposta em contrato administrativo?
Authors: Gonçalves Luciana Helena , Raffa Guilherme Rigueti
Published: October 2023

Este artigo objetiva refletir sobre a inclusão de condição resolutiva em contrato de direito administrativo em face da Lei n. 14.133/2021 (Nova Lei de Licitações) e da teoria dos negócios jurídicos. Nosso método de pesquisa utiliza-se de teoria brasileira e estrangeira, e também de dados empíricos a fim de compreender o fenômeno estudado. Pretende-se indicar estudo da condição resolutiva como possível cláusula complementar do contrato administrativo, cuja produção de efeitos deve ser considerada pelas partes contratantes. Examinaremos conceitos de direito civil e de direito público alemão, a fim de compreender, reflexivamente, sobre nosso próprio tratamento jurídico sobre a matéria. Nossos dados empíricos mostrarão que desconhecer a teoria dos negócios jurídicos poderá implicar riscos para a prática contratual administrativa.
A crise de desenvolvimento econômico no Brasil: impactos da Lei nº 13.467/2017 e a vulnerabilidade social dos direitos do trabalhador
Authors: Zipperer Fabrício Gonçalves , Zipperer André Gonçalves
Published: October 2023

A chamada reforma trabalhista, lei n° 13.467, sancionada em julho de 2017, trouxe um novo contexto social devido a alteração da dinâmica nas relações entre o capital e o trabalho, com inúmeras ações diretas de inconstitucionalidades interpostas no Supremo Tribunal Federal, com julgamentos ainda pendentes, além das inquietações políticas, sendo necessário uma análise do direito nos momentos de crise e a dinâmica do desenvolvimento econômico e social no Brasil pós-reforma. Serão apresentados alguns elementos científicos para a compreensão da regulamentação legislativa estatal, passando pela análise metodológica própria da economia e da administração, então, a partir desta ótica, para finalmente estabelecer uma maior competitividade frente a grande alteração dos métodos de produção do Século XXI, não afetando o princípio da vedação do retrocesso social ou da irreversibilidade dos direitos fundamentais. A importância de uma alternativa “legal” ao modelo apresentado pelo Governo Federal, utilizando-se do princípio constitucional da ordem econômica, sob a ótica do direito normativo, prevendo tratamento jurídico trabalhista “digno” ao pleno emprego, visando incentivo pela simplificação das obrigações administrativas, tributárias, previdenciárias e creditícias, ou pela simples eliminação ou redução destas por meio de uma lei mais competitiva, sem qualquer entrave legal ou constitucional e com a participação efetiva das entidades representativas, principalmente da classe trabalhadora.
Systematic evaluation of the impact of chia seeds on weight loss
Authors: Waruguru Phyllis
Published: October 2023

This review aims to assess the weight loss effects of chia seeds. Previous studies have documented contradictory findings on chia seeds and their impact on weight loss, hence necessitating a review to clarify this. The primary objective of this study is to evaluate the influence of chia seed consumption on weight loss in individuals participating in Randomised Control Trials. A systematic search was conducted in ClinicalKey, Cochrane, PubMed, Google Scholar, and Hinari.  RCTs that investigated the impact of chia seed consumption on weight loss were included in this study, and data on study design, blinding, participant characteristics, chia seed interventions, and placebos were extracted and analysed. Seven studies were analysed. Four documented significant weight loss in the chia seed group when combined with a hypocaloric diet, while two studies indicated minimal weight loss when chia seeds were consumed alongside a normal diet, and one study reported no weight loss among participants on a normal diet and chia seeds supplementation. These findings suggest that chia seed consumption when combined with a hypocaloric diet, can lead to significant weight loss. However, further research with longer intervention periods is necessary to establish the efficacy and optimal dosages of chia seed supplementation for effective weight management. This review, therefore, notes the importance of dietary context in realising the potential benefits of chia seeds in weight loss and highlights the need for more clinical trials in this area.
Uso da geotecnologia na análise morfométrica da bacia hidrográfica do rio Baios
Authors: Gritti Odirvan , Boza Daniela , Trentin Romario
Published: October 2023

O estudo das bacias hidrográficas possibilita monitorar os ecossistemas devido às suas características de uso do solo. Nesse contexto, entende-se que os fatores fisiográficos são importantes na caracterização, planejamento e manejo de uma bacia hidrográfica, como, por exemplo, caracterizá-la com predisposição ou não a enchentes. Levando em consideração esse contexto, objetivou-se fazer uso de geotecnologia para a obtenção de dados da Bacia Hidrográfica do Rio Baios, por meio da sua análise morfométrica, analisando o uso e ocupação do solo da bacia e das áreas de preservação permanentes das nascentes. Enquanto método, utilizou-se os softwares QGis, de plataforma livre e ArcGIS.10.8. Os resultados mostram que essa região possui um relevo ondulado, pequenos fragmentos de floresta e uma baixa predisposição natural para a ocorrência de eventos relacionados a enchentes.
Educação de Jovens e Adultos (EJA): ensinar e formar para a cidadania na escola com a geografia e a história
Authors: Carvalho Josias Ivanildo Flores de , Santos Francisco Kennedy Silva dos
Published: October 2023

A Educação de Jovens e Adultos (EJA) é uma das modalidades da educação básica brasileira. Deste modo, a Geografia e a História são disciplinas que possuem conteúdos e temas que podem contribuir para a formação de uma sociedade melhor. Este manuscrito tem o objetivo geral: compreender o papel da Geografia e da História na Educação de Jovens e Adultos (EJA) voltada a cidadania; sendo assim, a pesquisa está fundamentada na abordagem qualitativa, do tipo bibliográfica. Os procedimentos científicos adotados foram leitura e reflexão de artigos, livros, leis e normas educacionais, tanto do campo da Geografia, da História e da Educação. As conclusões detectadas foram as seguintes: o trabalho conduz a compreensão que a Geografia e a História na Educação de Jovens e Adultos (EJA) possuem papel chave para a formação de sujeitos mais críticos e reflexivos em relação a formação do espaço geográfico em uma perspectiva histórica, posto que os estudantes irão estudar conteúdos que estão relacionados a sua vida, conduzindo assim o exercício da cidadania em uma sociedade contemporânea cada vez mais complexa. Entendeu-se que a EJA está presente na LDBEN de 1996 como direito para os jovens e adultos que não conseguiram concluir os estudos, além de garantir outros direitos desses sujeitos e estabelece diretrizes para o funcionamento desta modalidade nas redes e sistemas de educação básica pública no Brasil. A escola e os professores na EJA possuem um papel de mediação essencial para que esta modalidade de ensino cumpra suas funções. Entretanto, a formação inicial e a formação continuada precisam dar mais atenção a EJA objetivando apropriar melhor os professores das diferentes disciplinas em relação a esta modalidade de educação que poderão lecionar.
APPLICATION OF PROBLEM-BASED LEARNING MODEL ON MULTIPLICATION AND DIVISION MATERIAL TO IMPROVE STUDENT LEARNING OUTCOMES IN GRADE III SD NEGERI 4 BANDA ACEH
Authors: Ramli Soleha Puteri Mohamad , Annisa Syaila
Published: October 2023

Based on observations, one of the problems in SD Negeri 4 Kota Banda Aceh is the low learning outcomes of students in mathematics subjects. The application of  the Problem Based Learning model  can provide a pleasant atmosphere for students in learning multiplication and division material. This study used the type of Classroom Action Research (PTK). The subjects of this study amounted to 23 students of grade III-B SD Negeri 4 Banda Aceh City, data collection techniques were carried out by observation, documentation, and learning outcomes tests. The technique of analyzing data from observations of student activities is with percentage descriptive statistics and individual student learning outcomes data. Based on the results of research in cycles I, II, and III obtained the following data: (1) the results of observations on student activities in learning observed for three cycles, increased in each cycle, namely: student activity in cycle I reached 82% of the good category, cycle II reached 84% of the good category, and cycle III reached 98% of the very good category. (2) the learning outcomes of students in multiplication and division material increased in cycle I of classical completeness criteria reaching 34% with an average value of 57.39, in cycle II classical completeness criteria of 69% with an average value of 71.37, while cycle III of classical completeness criteria 91% with an average value of 84.34. It was concluded that the Problem Based Learning learning model  on multiplication and division material can improve the learning outcomes of grade III-B students of SD Negeri 4 Banda Aceh City.
The Orbital Dynamics of Auditor Firm Rotation: Implications for Auditor Independence and Audit Quality
Authors: DELIU Delia , OLARIU Andrei-Marius
Published: October 2023

Another trip around the sun? How does the auditor orbit the audit engagement? The primary objective of any audit engagement is to gather sufficient relevant audit evidence for the auditor to render an opinion on the financial statements. Previous research has illustrated that the compulsory rotation of audit firms yields positive effects on audit quality. The rationale behind auditor rotations lies in their potential to enhance audit quality by mitigating the risk of auditors becoming excessively familiar with clients, which could compromise their independence and impartiality.
A REALIDADE DO SISTEMA PRISIONAL DO BRASIL E A DIGNIDADE DA PESSOA HUMANA
Authors: Santos Rayane Gabriela da Silva , Carvalho Filho Gilson Ribeiro
Published: October 2023

O sistema prisional do Brasil enfrenta desafios críticos que afetam diretamente a dignidade da pessoa humana. Este artigo analisa a situação atual das prisões brasileiras e como ela impacta os direitos fundamentais dos detentos. A pesquisa tem como objetivo discutir a real situação do sistema prisional brasileiro e expor seus mais relevantes problemas devido à falta de uma eficiente estrutura dentro dos presídios o sistema carcerário transparece de forma cristalina o desprezo e indiferença pela reabilitação do preso, que perece por tamanha indiferença e falta de segurança. Contudo, nota-se que as prisões no Brasil podem na grande maioria das vezes não proporcionar ao reeducando a sua recuperação, visando, portanto, este estudo justamente abordar sobre as garantias e direitos inerentes aos apenados que infelizmente não possuem efetividade. Dessa maneira, o presente estudo planeja-se analisar o sistema penitenciário brasileiro, uma vez que as práticas cotidianas no ambiente prisional e de aplicação da lei penal implicam, algumas vezes, violação dos direitos fundamentais dos apenados. Sobre a montagem do texto, foi utilizado o método bibliográfico e descritivo, com base em doutrinas e na legislação, para assim ter uma análise completa, clara e transparente à luz da temática proposta.
ASSESSMENT OF THE ANTIFUNGAL ACTIVITY OF Cymbopogan citratus (Lemon grass) LEAF EXTRACT AGAINST SOME PHYTOPATHOGENS
Authors: ORIBHABOR G. O. , IYEKEKPOLOR S. I.
Published: October 2023

Since the beginning of mankind, nature has been a source of medicinal agent for thousands of years. A plant pathogen is an infectious organism that is capable of causing disease to plants. This research work was aimed at assessing the antifungal activity of Cymbopogan citratus leaf extract on some phytopathogenic fungi isolated from agricultural soils. Aspergillus niger, Aspergillus tamari and Mucor circinelloides were isolated from an agricultural soil.  Aspergillus tamari displayed highest susceptibility to the 50% ethanolic extract of the plant with a mycelial radial growth inhibition measurement of 18.25 ± 0.25 mm while Mucor circinelloides displayed the least susceptibility to the 100% ethanolic extract with a mycelial radial growth inhibition of 45.25 ± 0.25 mm. The results were significantly different from the controls (63.25 ± 0.75 mm, Aspergillus niger; 43.25 ± 1.25 mm, Aspergillus tamari and 63.75 ± 0.75 mm, Mucor circinelloides). In the same vein, the aqueous extract also displayed appreciable antifungal activity. The radial growth inhibition of the aqueous extract ranged from 24.25 ± 0.25 mm (25%, Mucor circinelloides) to 34.50 ± 0.50mm (100%, Aspergillus tamari). These were significantly different from the controls. This Study has shown that lemon grass leaf extract possesses antifungal activities to control phytopathogens, from the result obtained, it can be stated that lemon grass can be exploited as an alternative to chemical fungicides in combating resistance amongst phytopathogens.
Evaluation of Coagulation Activities of Moringa oleifera Seeds and Aluminium sulphate on the Treatment of Wastewater from Biodiesel Production
Authors: SALOKUN O. , OSARUMWENSE J. O.
Published: October 2023

The production of clean biodiesel from vegetable oil generates a large quantity of toxic wastewater. Most researches have been focused on the technical process of biodiesel production but the environmental management of the wastewater generated from the production process has not been given adequate attention. In this study, treatment of wastewater from biodiesel production by coagulation activities of defatted Moringa oleifera seed (DMOS) and inorganic coagulant, Aluminium sulphate (AlSP) was examined. Proximate analysis was carried out on the DMOS powder; and it was also characterized by Fourier Transform Infra-Red (FTIR) analysis. The coagulation process was carried out within 48 hours in jar test apparatus using 0.1%, 0.2%, 0.3%, 0.4% and 0.5% (w/v) of DMOS and AlSP respectively. The results show that 84.54% and 85.65% turbidity reduction occurred at coagulant dosage of 0.2% within 12 hours by DMOS and AlSP respectively. The FTIR analysis of DMOS showed functional groups such as O-H, C-O, and N-H indicating the presence of carbohydrates, esters and proteins respectively. It was suggested that the presence of a cationic protein of high molecular weight destabilizes the dissolved particles in the wastewater, and by a process of neutralization and adsorption, the flocculation and sedimentation activities occurred. Hence, it can be indicated that DMOS powder can effectively be used in place of inorganic coagulant to remove turbidity in biodiesel wastewater.