bluuebunny/crossref_metadata_2025 huggingface dataset:
Aberrant expression of FBXO22 is associated with propofol-induced synaptic plasticity and cognitive dysfunction in adult mice
Authors: Yang Xiaoxuan , Chen Chen , Qu Dongmei , Liu Yanping , Wang Ning , Wang Haibi , Fan Youjia , Zhou Yushan , Yu Buwei , Xue Qingsheng , Wu Yuqing , Lu Han
Published: November 2022

Recent observation demonstrated that prolonged anesthesia modifies brain synaptic architecture in all ages, including adult. Propofol is the most commonly utilized anesthetics at clinic. Whether repeated administration of propofol modulates cognitive impairment in adults and changes synaptic plasticity remains, however, to be explored. In this study, we first discovered that repeated and prolonged exposure to propofol-induced cognitive impairment in adult rodents. Then, we examined the property of hippocampal primary neurons and slices after propofol treatment in mice, including synaptic protein profile, dendritic spine density, as well as synaptic transmission. We found the distinctive change of the F-box only protein 22 (FBXO22), an F-box E3 ligase, during this process and further explored its role. Knockdown experiments showed the downregulation of FBXO22 restored the changes by propofol treatment on hippocampal primary neurons and attenuated propofol-induced hippocampal dependent cognitive dysfunction. Our results showed that FBXO22 is involved in the regulation of repeated propofol treatment induced changes of synaptic plasticity and cognitive dysfunction in adult mice. Repeated propofol treatment leads to cognitive dysfunction by regulating FBXO22 in adult rodents.
A novel single robot image shadow detection method based on convolutional block attention module and unsupervised learning network
Authors: Zhang Jun , Liu Junjun
Published: November 2022

Shadow detection plays a very important role in image processing. Although many algorithms have been proposed in different environments, it is still a challenging task to detect shadows in natural scenes. In this paper, we propose a convolutional block attention module (CBAM) and unsupervised domain adaptation adversarial learning network for single image shadow detection. The new method mainly contains three steps. Firstly, in order to reduce the data deviation between the domains, the hierarchical domain adaptation strategy is adopted to calibrate the feature distribution from low level to high level between the source domain and the target domain. Secondly, in order to enhance the soft shadow detection ability of the model, the boundary adversarial branch is proposed to obtain structured shadow boundary. Meanwhile, a CBAM is added in the model to reduce the correlation between different semantic information. Thirdly, the entropy adversarial branch is combined to further suppress the high uncertainty at the boundary of the prediction results, and it obtains the smooth and accurate shadow boundary. Finally, we conduct abundant experiments on public datasets, the RMSE has the lowest values with 9.6 and BER with 6.6 on ISTD dataset, the results show that the proposed shadow detection method has better edge structure compared with the existing deep learning detection methods.
Dynamic changes of otolith organ function before and after repositioning in patients with benign paroxysmal positional vertigo detected by virtual reality auxiliary technology: A cohort study
Authors: Zhao Chunjie , Yang Qingjun , Song Jijun
Published: November 2022

Objectives

To dynamically investigate otolith function in patients with benign paroxysmal positional vertigo (BPPV) before, after, and 1 month after repositioning, and explore the possible compensation mechanisms.

Methods

Thirty-six patients confirmed with BPPV (canal lithiasis) treated in our hospital between August 2020 and March 2021, as well as 36 health controls matched for age and gender (normal control group, NC group) were enrolled. For NC group, the virtual reality (VR) auxiliary static subjective visual vertical (SVV), subjective visual horizontal (SVH), and SVV of dynamic unilateral centrifugation (DUC), were measured at inclusion. For the BPPV group, visual analog scale (VAS) was used to assess the vertigo degree, while static SVV, SVH, and DUC were performed before, after, and 1 month after repositioning. First, we compare the deviations of SVV0/SVH0° when the subject's head is in the positive position, and SVV of DUC between BPPV and NC groups before repositioning, after which we compared the deviations in SVV45, SVV90, SVH45, SVH90°, and SVV of DUC between the affected and unaffected sides before repositioning. Finally, paired t-test was used to compare the VAS score, deviations in static SVV0, SVV45, SVV90, SVH0, SVH45, and SVH90°, and deviations in SVV of DUC before, after, and 1 month after repositioning. (Here, 0, 45, and 90° refer to the angle which the center axis of head deviates from the gravity line.)

Results

SVV0 SVH0°, and SVV of DUC at 120 and 180°/s 0 significantly differed between BPPV and NC group before repositioning. The deviations in SVV45, SVV90, SVH45, SVH90°, and SVV of DUC at 120°/s-2 and 180°/s-4.5 did not significantly differ between bilateral sides in BPPV patients before repositioning. The deviation in SVH90° was significantly lower after repositioning than before. The deviation in SVH45° was significantly higher 1 month after repositioning than before. The deviation angle of SVV of DUC at 180°/s-0 was significantly lower after repositioning than before. The vertigo VAS score of patient with BPPV continued to decrease after repositioning.

Conclusion

Before repositioning, the otolithic organ function of BPPV patients was obviously impaired, with no significant difference between the healthy and affected ear. After repositioning, there was a transient recovery of otolithic organ dysfunction followed by a sustained decline to similar levels to before repositioning.
Immediate effect of lower extremity joint manipulation on a lower extremity somatosensory illusion: a randomized, controlled crossover clinical pilot study
Authors: Schueren Shannon , Hunger Hugh , Pham Huong , Smith Dean L. , Layne Charles , Malaya Christopher A.
Published: November 2022

Objective:This study explored the influence of lower extremity manipulation on the postural after-effects of standing on an inclined surface.

Methods:Eight healthy individuals (28.0 ± 4.1 years) were recruited for this open-label, crossover study. Participants stood on an incline board for 3 min to develop a known form of somatosensory illusion. After randomization to either a lower-extremity joint manipulation or no intervention, participants immediately stood on a force plate for 3 min with eyes closed. After a 24-h washout period, participants completed the remaining condition. Center of pressure (CoP) position data was measured by a force plate and evaluated using statistical parametric mapping. Pathlength, mean velocity, and RMS were calculated for significant time periods and compared with corrected pairedt-tests.

Results:Parametric maps revealed that CoP position of control and intervention conditions differed significantly for two time periods (70–86 s—control: 0.17 ± 1.86 cm/intervention: −1.36 ± 1.54 cm; 141–177 s—control: −0.35 ± 1.61 cm/intervention: −1.93 ± 1.48 cm). CoP pathlength was also significantly decreased for the second period (control: 6.11 ± 4.81 cm/intervention: 3.62 ± 1.92 cm).

Conclusion:These findings suggest that extremity manipulation may be a useful intervention for populations where CoP stability is an issue. This study contributes to the growing body of evidence that manipulation of the extremities can drive global postural changes, as well as influence standing behavior. Further, it suggests these global changes may be driven by alterations in central integration.

Clinical Trial Registration:ClinicalTrials.gov, NCT Number: NCT05226715.
COVID-19 vaccination in patients with cancer: Opportunities and challenges
Authors: Al-qaim Zahraa Haleem , Owadh Hasanain Kamil Hasan , Ali Sarah A. , Hussein Alaa S. , Ameen Thamer Ramadhan , Kolemen Ayshan , Washi Ghassan A. , Jalil Abduladheem Turki
Published: November 2022

The rapid spread of the SARS-Cov-2 virus, the increase in the number of patients with severe COVID-19, and the high mortality rate created the basis for the production of safe and effective vaccines. Studies have confirmed the increased risk of severe Covid-19 disease and mortality in cancer patients. It is logical that cancer patients should be the first to receive the primary vaccination and the booster vaccine for Covid-19. Since studies related to cancer patients and the effectiveness of existing Covid-19 vaccines have not been widely conducted, there are significant uncertainties about the effectiveness of the vaccine and the level of humoral and cellular immune responses in these patients. As a result, the possible risks and side effects of existing vaccines are not clear for patients with different cancers who are undergoing special treatments. In this study, we will discuss the effectiveness and safety of existing vaccines on cancer patients. In addition, we highlight factors that could affect the effectiveness of vaccines in these patients and finally discuss opportunities and challenges related to vaccination in cancer patients.
Association between exposure to earthquake in early life and diabetes mellitus incidence in adulthood with the modification of lifestyles: Results from the Kailuan study
Authors: Shui Xinying , Zhao Lei , Li Wenli , Jia Yaning , Liu Ziquan , Li Chen , Yang Xueli , Huang Haoran , Wu Shouling , Chen Shuohua , Gao Jingli , Li Xiaolan , Wang Aitian , Jin Xiaobin , Guo Liqiong , Hou Shike
Published: November 2022

Background

Exposure to disasters in early life may induce lifetime health risk, but investigation on earthquake exposure and DM in later life is still limited. The aim of the current study is to evaluate the association between exposure to the Tangshan Earthquake in early life and diabetes mellitus (DM) incidence in adulthood, and explore the modification of lifestyles on DM development.

Methods

Participants who were free of DM at baseline from the Kailuan Study were included in this study. All participants were divided into fetal-exposed, infant-exposed, early childhood-exposed and nonexposed group. The effect of earthquake exposure on DM and modification of lifestyles were examined by multivariable-adjusted Cox proportional hazard model.

Results

The exposed group had a higher risk of DM than nonexposed group, especially in infant-exposed and early childhood-exposed group, with hazard ratio (HR) of 1.62 [95% confidence intervals (CI), 1.21–2.17] and 1.46 (95% CI, 1.06–1.99), respectively. After stratifying by lifestyles, a significant modification was observed in alcohol consumption.

Conclusion

Exposing to earthquake in early life could increase DM incidence in later life, and alcohol consumption might modify the effect of earthquake exposure on DM development. More attention should be paid on the preventions of DM among adults who exposed to earthquake in their early life.
Effects of strength exercise interventions on activities of daily living, motor performance, and physical activity in children and adolescents with leukemia or non-Hodgkin lymphoma: Results from the randomized controlled ActiveADL Study
Authors: Gaser Dominik , Peters Christiane , Oberhoffer-Fritz Renate , Götte Miriam , Feuchtinger Tobias , Schmid Irene , Haller Bernhard , von Luettichau Irene , Kesting Sabine
Published: November 2022

Objectives

Pediatric patients with cancer experience impairments in muscle strength and physical activity (PA) that may reduce autonomy during hospitalization. To determine the effects of strength exercise interventions on the accomplishment of activities of daily living (ADLs), motor performance, and PA in children with leukemia or non-Hodgkin lymphoma, we randomly allocated patients (4–18 years) immediately after diagnosis into two exercise groups.

Methods

The intervention group (IG; n = 21) received a specific strength training combined with a standard care exercise program, whereas the control group (CG; n = 20) was provided standard care exercise program without any targeted muscle strengthening. After the baseline visit, participants were followed-up three times until intensive treatment cessation. We assessed physical function limitations using the Activities Scale for Kids© (ASK) and Functional ADL Screen. Secondary outcomes were PA levels using accelerometer and motor performance as measured by MOON-test (motor performance in pediatric oncology-test).

Results

In both groups, ADL accomplishment had significantly increased (p < 0.05). However, no significant between-group differences for ASK outcome were noted. Motor performance was reduced in all motor abilities.

Conclusions

Both exercise interventions were effective to maintain ADLs and motor performance during intensive treatment. In comparison, regular strength exercise interventions in the course of therapy tended to be more beneficial with regards to muscular explosive and endurance strength.
New insights in ferroptosis: Potential therapeutic targets for the treatment of ischemic stroke
Authors: Wei Ziqing , Xie Yi , Wei Mingze , Zhao Huijuan , Ren Kaidi , Feng Qi , Xu Yuming
Published: November 2022

Stroke is a common disease in clinical practice, which seriously endangers people’s physical and mental health. The neurovascular unit (NVU) plays a key role in the occurrence and development of ischemic stroke. Different from other classical types of cell death such as apoptosis, necrosis, autophagy, and pyroptosis, ferroptosis is an iron-dependent lipid peroxidation-driven new form of cell death. Interestingly, the function of NVU and stroke development can be regulated by activating or inhibiting ferroptosis. This review systematically describes the NVU in ischemic stroke, provides a comprehensive overview of the regulatory mechanisms and key regulators of ferroptosis, and uncovers the role of ferroptosis in the NVU and the progression of ischemic stroke. We further discuss the latest progress in the intervention of ferroptosis as a therapeutic target for ischemic stroke and summarize the research progress and regulatory mechanism of ferroptosis inhibitors on stroke. In conclusion, ferroptosis, as a new form of cell death, plays a key role in ischemic stroke and is expected to become a new therapeutic target for this disease.
Generation of individual daily trajectories by GPT-2
Authors: Mizuno Takayuki , Fujimoto Shouji , Ishikawa Atushi
Published: November 2022

We propose a new method to convert individual daily trajectories into token time series by applying the tokenizer “SentencePiece” to a geographic space divided using the Japan regional grid code “JIS X0,410.” Furthermore, we build a highly accurate generator of individual daily trajectories by learning the token time series with the neural language model GPT-2. The model-generated individual daily trajectories reproduce five realistic properties: 1) the distribution of the hourly moving distance of the trajectories has a fat tail that follows a logarithmic function, 2) the autocorrelation function of the moving distance exhibits short-time memory, 3) a positive autocorrelation exists in the direction of moving for one hour in long-distance moving, 4) the final location is often near the initial location in each individual daily trajectory, and 5) the diffusion of people depends on the time scale of their moving.
Building surrogate models of nuclear density functional theory with Gaussian processes and autoencoders
Authors: Verriere Marc , Schunck Nicolas , Kim Irene , Marević Petar , Quinlan Kevin , Ngo Michelle N. , Regnier David , Lasseri Raphael David
Published: November 2022

From the lightest Hydrogen isotopes up to the recently synthesized Oganesson (Z = 118), it is estimated that as many as about 8,000 atomic nuclei could exist in nature. Most of these nuclei are too short-lived to be occurring on Earth, but they play an essential role in astrophysical events such as supernova explosions or neutron star mergers that are presumed to be at the origin of most heavy elements in the Universe. Understanding the structure, reactions, and decays of nuclei across the entire chart of nuclides is an enormous challenge because of the experimental difficulties in measuring properties of interest in such fleeting objects and the theoretical and computational issues of simulating strongly-interacting quantum many-body systems. Nuclear density functional theory (DFT) is a fully microscopic theoretical framework which has the potential of providing such a quantitatively accurate description of nuclear properties for every nucleus in the chart of nuclides. Thanks to high-performance computing facilities, it has already been successfully applied to predict nuclear masses, global patterns of radioactive decay like β or γ decay, and several aspects of the nuclear fission process such as, e.g., spontaneous fission half-lives. Yet, predictive simulations of nuclear spectroscopy—the low-lying excited states and transitions between them—or of nuclear fission, or the quantification of theoretical uncertainties and their propagation to basic or applied nuclear science applications, would require several orders of magnitude more calculations than currently possible. However, most of this computational effort would be spent into generating a suitable basis of DFT wavefunctions. Such a task could potentially be considerably accelerated by borrowing tools from the field of machine learning and artificial intelligence. In this paper, we review different approaches to applying supervised and unsupervised learning techniques to nuclear DFT.
Radon concentration variations at the Yangyang underground laboratory
Authors: Ha C. , Jeong Y. , Kang W. G. , Kim J. , Kim K. W. , Kim S. K. , Kim Y. D. , Lee H. S. , Lee M. H. , Lee M. J. , Lee Y. J. , Seo K. M.
Published: November 2022

The concentration of222Rn in the air has been measured in the 700 m-deep Yangyang underground laboratory between October 2004 and May 2022. The average concentrations (spreads) in two experimental areas, called A6 and A5, were measured to be 53.4 Bq/m3(13.9 Bq/m3) and 33.5 Bq/m3(7.9 Bq/m3), respectively. The lower value in the A5 area reflects the presence of better ventilation. The radon concentrations sampled within the two A5 experimental rooms’ air are found to be correlated to the local tunnel temperature outside of the rooms, with correlation coefficientsr= 0.22 andr= 0.70. Therefore, the radon concentrations display a seasonal variation, because the local temperature driven by the overground season influences air ventilation in the experimental areas. A sinusoidal function with a period of 1 year was used to fit the radon concentration data of both underground areas finding a maximum amplitude on August, 31 ± 6 days.
A 3D-CNN with temporal-attention block to predict the recurrence of atrial fibrillation based on body-surface potential mapping signals
Authors: Zhong Gaoyan , Feng Xujian , Yuan Han , Yang Cuiwei
Published: November 2022

Catheter ablation has become an important treatment for atrial fibrillation (AF), but its recurrence rate is still high. The aim of this study was to predict AF recurrence using a three-dimensional (3D) network model based on body-surface potential mapping signals (BSPMs). BSPMs were recorded with a 128-lead vest in 14 persistent AF patients before undergoing catheter ablation (Maze-IV). The torso geometry was acquired and meshed by point cloud technology, and the BSPM was interpolated into the torso geometry by the inverse distance weighted (IDW) method to generate the isopotential map. Experiments show that the isopotential map of BSPMs can reflect the propagation of the electrical wavefronts. The 3D isopotential sequence map was established by combining the spatial–temporal information of the isopotential map; a 3D convolutional neural network (3D-CNN) model with temporal attention was established to predict AF recurrence. Our study proposes a novel attention block that focuses the characteristics of atrial activations to improve sampling accuracy. In our experiment, accuracy (ACC) in the intra-patient evaluation for predicting the recurrence of AF was 99.38%. In the inter-patient evaluation, ACC of 3D-CNN was 81.48%, and the area under the curve (AUC) was 0.88. It can be concluded that the dynamic rendering of multiple isopotential maps can not only comprehensively display the conduction of cardiac electrical activity on the body surface but also successfully predict the recurrence of AF after CA by using 3D isopotential sequence maps.
Model construction and validation of airflow velocity attenuation through pear tree canopies
Authors: Zhang Fubin , Sun Hao , Qiu Wei , Lv Xiaolan , Chen Yunfu , Zhao Guozhu
Published: November 2022

To investigate the airflow velocity attenuation inside pear tree canopies and the factors that influence its effect on air-assisted spraying, the relationship between the resistance of the canopies to airflow and airflow velocity inside the canopies was determined. At the same time, the theoretical model of airflow velocity attenuation in the canopy was constructed, in which the velocity attenuation factor k and the incoming velocity were the model input values, and the airflow velocity in the canopy was the model output value. Then, experimental verification of the theoretical model was completed. The determination test of airflow velocity inside canopies with three leaf area densities revealed that the error range between the established theoretical model and the experimental airflow velocity inside the pear tree canopy was 0.11–1.25 m/s, and the mean size of the model accuracy was 83.4% under various working conditions. The results revealed that the region from a depth of 0 m to 0.3 m inside the canopy was the rapid attenuation area of the airflow and that from 0.3 m to 0.9 m was the low attenuation area. Furthermore, they revealed that high-speed airflow could strongly disturb the outer branches and leaves, greatly changing the windward area of the canopy blades and thus affecting the accuracy of the model. By introducing a dynamic parameter of the canopy leaf windward area for model correction, the R2 of the model was above 0.9. Finally, validation of the model was performed in an air-assisted spraying operation in an orchard. This study can provide a theoretical basis for the regulation of airflow parameters of air-assisted spraying of pear trees.
Comprehensive analysis of glycerolipid dynamics during tobacco pollen germination and pollen tube growth
Authors: Serrano Natalia , Pejchar Přemysl , Soukupová Hana , Hubálek Martin , Potocký Martin
Published: November 2022

Pollen germination and subsequent pollen tube elongation are essential for successful land plant reproduction. These processes are achieved through well-documented activation of membrane trafficking and cell metabolism. Despite this, our knowledge of the dynamics of cellular phospholipids remains scarce. Here we present the turnover of the glycerolipid composition during the establishment of cell polarity and elongation processes in tobacco pollen and show the lipid composition of pollen plasma membrane-enriched fraction for the first time. To achieve this, we have combined several techniques, such as lipidomics, plasma membrane isolation, and live-cell microscopy, and performed a study with different time points during the pollen germination and pollen tube growth. Our results showed that tobacco pollen tubes undergo substantial changes in their whole-cell lipid composition during the pollen germination and growth, finding differences in most of the glycerolipids analyzed. Notably, while lysophospholipid levels decrease during germination and growth, phosphatidic acid increases significantly at cell polarity establishment and continues with similar abundance in cell elongation. We corroborated these findings by measuring several phospholipase activities in situ. We also observed that lysophospholipids and phosphatidic acid are more abundant in the plasma membrane-enriched fraction than that in the whole cell. Our results support the important role for the phosphatidic acid in the establishment and maintenance of cellular polarity in tobacco pollen tubes and indicate that plasma membrane lysophospholipids may be involved in pollen germination.
Effect of the At-CDC27a gene on Nicotiana benthamiana phenotype and accumulation of recombinant proteins
Authors: Kopertekh Lilya , Reichardt Sven
Published: November 2022

In this study the anaphase promoting complex subunit CDC27a from Arabidopsis thaliana was introduced in the genome of Nicotiana benthamiana by Agrobacterium tumefaciens. The presence of the At-CDC27a gene facilitates plant biomass production. Compared to wild type N. benthamiana the leaf mass fraction of the best performing transgenic line At-CDC27a-29 was increased up to 154%. The positive effect of the At-CDC27a expression on leaf biomass accumulation was accompanied by an enlarged total leaf area. Furthermore, the ectopic expression of the At-CDC27a also affected cellular conditions for the production of foreign proteins delivered by the TRBO vector. In comparison to the non-transgenic control, the protein accumulation in the At-CDC27a-29 plant host increased up to 146% for GFP and up to 181% for scFv-TM43-E10. Collectively, the modified N. benthamiana plants developed in this study might be useful to improve the yield of recombinant proteins per biomass unit in closed facilities.
Exploring the health information seeking behavior of social media users under the background of COVID-19 pandemic: An empirical study based on social cognitive theory
Authors: Zhang Xiaoyi , Chen Beibei , Li Guowang , Dong Yueqi
Published: November 2022

With the outbreak of COVID-19 in late 2019, people’s awareness of actively searching for health information has been growing. Coupled with the promotion of “Internet + medical and health,” social media, as an important platform for health information dissemination, has become one of the important information sources for users to obtain health information. However, health information seeking behavior in public health emergencies are quite different from those in daily life. Therefore, the research question of this paper is to explore the influencing factors of health information seeking behavior of social media users in the context of COVID-19. To this end, based on the research framework of social cognition theory, this paper selects six variables to construct a structural equation modeling, including information and platform quality, experience, social support, emotional arousal, self-efficacy, and social media users’ health information seeking behavior. The empirical study is carried out by collecting 219 valid questionnaires. The research results show that: (1) Information and platform quality, and use experience have a significant positive effect on emotional arousal; (2) Experience, social support, and emotional arousal have a significant positive effect on self-efficacy; (3) Emotional arousal and self-efficacy have a significant positive effect on social media users’ health information seeking behavior. The research provides an important theoretical reference for social media users and operators to cope with the huge demand for health information in the post-COVID-19 era.
Latent transition analysis in organizational psychology: A simplified “how to” guide by using an applied example
Authors: Zyberaj Jetmir , Bakaç Cafer , Seibel Sebastian
Published: November 2022

Demands for more robust designs in organizational research have led to a steady increase in the number of longitudinal studies in organizational psychology (OP) journals. Similarly, the number and ways to analyze longitudinal data have also increased. In this paper, we adopt a relatively new and promising approach to help researchers analyze their longitudinal data in OP, namely latent transition analysis (LTA). We present a simplified guideline on LTA and discuss its role for OP researchers. Moreover, we demonstrate how organizational scholars can use this method with a practical example. In this example, we investigate (a) if there are qualitatively distinct subgroups of employees based on particular patterns of psychological capital (PsyCap) dimensions (i.e., efficacy, hope, resilience, and optimism), (b) if employees stay in these subgroups or transition to other groups over time, and finally, (c) if leader-member exchange (LMX) is associated with this transition. We use LTA to examine these steps in a German sample (N = 180).
The discursive (re)construction of social relations in a crisis situation: A genre analytical approach to press conferences on COVID-19 in China
Authors: Wang Hong , Ge Yunfeng
Published: November 2022

The outbreak of COVID-19 has imposed a great threat both to people’s health and to social relations. By following the theoretical constructions of critical genre analysis and critical discourse analysis and drawing on the 35 press conferences on the COVID-19 outbreak in China, this paper explores how the discourse of press conferences is used by the Chinese government as a means of crisis management to (re)construct social relations. The analysis of the data reveals a hybridity of social relations reproduced discursively between such social actors as government institutions, the general public, medical institutions or staff, and COVID-19 patients, and a distinct feature of interdiscursivity of the discourse of press conferences on COVID-19, with descriptive, instructional, strategic, and evaluative discourses being the most frequently employed. It is also found that political, professional, social, and cultural forces are interwoven with each other to contribute to the interdiscursivity of the discourse of press conferences and the hybridity of social relations constructed thereof.
Factors affecting face mask-wearing behaviors to prevent COVID-19 among Thai people: A binary logistic regression model
Authors: Kaewpan Wonpen , Rojpaisarnkit Kunwadee , Pengpid Supa , Peltzer Karl
Published: November 2022

Objectives

Face mask wearing is a standard preventive measure, in addition to handwashing and physical distancing. Individuals may find that wearing a face mask protects their physical health and prevents viral transmission. However, none of the studies in Thailand identified factors associated with face mask-wearing behaviors among Thai people. Therefore, this study aims to determine factors affecting face mask-wearing behaviors to prevent COVID-19.

Methods

This research is analytical survey research. The data used in this study were under the project title “The assessment of psychosocial and behavioral response and compliance to restriction measures to prevent and control COVID-19: A series of the rapid survey.” A total of 6,521 people participated in an online survey by multi-stage sampling. Bivariate logistic regression analysis was used to examine the factors associated with face mask-wearing behaviors.

Results

After adjusting for independent variables (i.e., gender, age, education, career, smoking, and comorbidity disease), the bivariate logistic regression analysis revealed that gender, age, and career were statistically significant to the face mask-wearing behaviors (p < 0.05). Level of education, smoking, and comorbidity disease were not statistically significant with face mask-wearing behaviors among Thai people.

Conclusion

Further study should explore broader on individual face mask perceptions and wearing in the continuing of COVID-19 across gender, age, and careers to better understand their health behaviors and to inform further policy. In addition, the development of an intervention to promote face mask wearing should target men who age below 30 yrs. and did not work in government services careers as this group of the population was likely not to wear a face mask outside the home.
Do we need to vaccinate every child against COVID-19: What evidence suggests—A systematic review of opinions
Authors: Paul Sourabh , Mishra Chandra Mauli
Published: November 2022

It is still debatable whether all children should receive the COVID-19 vaccine. The comparatively mild cases and low risk of COVID-19 in children compared to adults, as well as the lack of clarity on the relative effects of the disease and vaccine, indicate that the risk-benefit ratio of vaccination in children is more nuanced. To consider and highlight the complexity of policy decisions regarding COVID-19 vaccination in children, we outlined the points regarding for and against vaccination of children against COVID-19 in this systemic review. Using Medical Search Headings (MeSH) terms and keywords, we searched PubMed, PubMed Central, Scopus, and Google Scholar. The primary search term was COVID-19 vaccination (all synonyms), factors (all synonyms), and among children (all synonyms). A total of 367 articles were searched. Finally, 64 articles met the inclusion criteria and were included in the review. The major theme/tone of 28 (43.75%) articles was in favor of children's COVID vaccination, and they were highlighting the positive factors, whereas the major theme/tone of 20 (31.25%) articles was against it. Approximately 16 (25.0%) articles were in a neutral position. Major factors highlighted by articles in favor of childhood COVID vaccination were as follows: the increasing rate of disease burden (29 articles), prevention of interruption of academic activities of children or school reopening (24 articles), and a role in defense against COVID infection (21 articles). Major factors against childhood vaccination were as follows: mild infection among children (27 articles), ethical concerns and legal problems regarding the consent of minors (17 articles), and vaccine hesitancy among parents for childhood vaccination (11 articles). Whereas, factors of uncertainty were the role in the reduction of community transmission (19 articles), protection against MIS-C (10 articles), and defense against long COVID (7 articles). Considering all the factors of COVID-19 disease progression among children, a cautious approach will be essential before proceeding with COVID-19 vaccination in children.
Self-harm among post-natal mothers in Northwest Ethiopia: Implication for policy and practice
Authors: Tiguh Agumas Eskezia , Wondie Kindu Yinges , Gessesse Dereje Nibret , Tsega Nuhamin Tesfa , Aklil Mastewal Belayneh , Temesgan Wubedle Zelalem , Abegaz Marta Yimam , Anteneh Tazeb Alemu , Tibebu Nebiyu Solomon , Alemu Haymanot Nigatu , Haile Tsion Tadesse , Seyoum Asmra Tesfahun , Mesele Tiruye Tilahun , Yismaw Ayenew Engida , Nenko Goshu , Taye Birhan Tsegaw , Mihret Muhabaw Shumye , Kebede Azmeraw Ambachew
Published: November 2022

Introduction

Self-harm is a global public health concern affecting thousands of women. However, it is an under-reported and neglected aspect of maternal health, particularly in developing countries. In Ethiopia, there is a paucity of evidence regarding self-harm, and it is rarely given attention. Therefore, this study aimed to assess the proportion of self-harm and associated factors among postnatal mothers in Gondar city, Northwest Ethiopia.

Method

A community-based cross-sectional study was conducted from 1 July, 2021, to 30 August, 2021, in Gondar city. A cluster sampling technique was conducted to select 858 women who gave birth in the last 12 months. The data were collected using a structured questionnaire through face-to-face interviews. The data were entered into EpiData version 4.6 and exported to SPSS 25 for analysis. The multivariable logistic regression analysis was fitted to identify factors associated with the outcome variable. The level of significant association was determined at a p-value of ≤ 0.05.

Result

The proportion of postnatal self-harm was found to be 8.5% (95% CI: 6.7,10.5). Having lower family income (AOR: 2.41, 95% CI: 1.05,5.56), having unplanned pregnancy (AOR: 2.70, 95% CI: 1.53,4.79), experiencing adverse birth outcomes (AOR: 3.11, 95% CI: 1.10,8.83), birth not attended by health provider (AOR: 4.15, 95% CI: 1.76,9.79), experiencing intimate partner violence (AOR: 1.93, 95% CI: 1.12,3.32), and poor decision-making power (AOR: 1.70, 95% CI: 1.02, 2.84) were the variables significantly associated with self-harm.

Conclusion

This study revealed that the proportion of self-harm among postnatal mothers was prevalent. Factors like monthly income of a family, planned pregnancy, birth outcome, birth assistant, intimate partner violence, and decision-making power show an association with maternal self-harm. Antenatal and postnatal self-harm screening as part of the continuum of maternal healthcare is important. Self-harm is also a danger for women who have experienced intimate partner violence or have low socioeconomic economic status, all of which require exceptional mental health assessment.
Prenatal second-hand smoke exposure and the risk of suspected developmental coordination disorder in preschoolers: A nationwide retrospective cohort study in China
Authors: Wu Meiqin , Williams Gareth J. , Chen Guixia , Zhang Lan , Hu Chunping , Dai Xiaotian , Du Wenchong , Hua Jing
Published: November 2022

Prenatal exposure to second-hand smoke (SHS) is associated with increased neurodevelopmental problems in children, however, its impact on the risk of developmental coordination disorder (DCD) in preschoolers have not been studied thoroughly. Herein, we probed this association based on a nationwide retrospective cohort study of 149,005 preschoolers in China. We divided the objects into the prenatal SHS-exposed group or the no prenatal smoke exposed group (NS-exposed group). Preschoolers were assessed for motor proficiency by the Chinese version of Little Developmental Coordination Disorder Questionnaire (LDCDQ). Multivariable logistic regression was used to evaluate the associations. The prevalence of prenatal SHS exposure was 23.89%. Generally, the prevalence of suspected DCD was significantly higher in prenatal SHS-exposed group (16.38% VS. 14.19%, P < 0.001). With the increase of age, the mean total scores of LDCDQ of both boys and girls increased gradually; and the prevalence of suspected DCD in girls was higher than that in boys in the same age group. After adjusting for covariates, prenatal SHS exposure had the negative association with the total score of LDCDQ and increased the risk of suspected DCD. Our results suggest a need for interventions designed to reduce maternal SHS exposure during pregnancy, early screen for DCD and increase targeted movement and coordination skill training for vulnerable children.
Adaptability of AI for safety evaluation in regulatory science: A case study of drug-induced liver injury
Authors: Connor Skylar , Li Ting , Roberts Ruth , Thakkar Shraddha , Liu Zhichao , Tong Weida
Published: November 2022

Artificial intelligence (AI) has played a crucial role in advancing biomedical sciences but has yet to have the impact it merits in regulatory science. As the field advances, in silico and in vitro approaches have been evaluated as alternatives to animal studies, in a drive to identify and mitigate safety concerns earlier in the drug development process. Although many AI tools are available, their acceptance in regulatory decision-making for drug efficacy and safety evaluation is still a challenge. It is a common perception that an AI model improves with more data, but does reality reflect this perception in drug safety assessments? Importantly, a model aiming at regulatory application needs to take a broad range of model characteristics into consideration. Among them is adaptability, defined as the adaptive behavior of a model as it is retrained on unseen data. This is an important model characteristic which should be considered in regulatory applications. In this study, we set up a comprehensive study to assess adaptability in AI by mimicking the real-world scenario of the annual addition of new drugs to the market, using a model we previously developed known as DeepDILI for predicting drug-induced liver injury (DILI) with a novel Deep Learning method. We found that the target test set plays a major role in assessing the adaptive behavior of our model. Our findings also indicated that adding more drugs to the training set does not significantly affect the predictive performance of our adaptive model. We concluded that the proposed adaptability assessment framework has utility in the evaluation of the performance of a model over time.
Effects of pharmacological neurotrophin receptor inhibition on bladder function in female mice with cyclophosphamide-induced cystitis
Authors: Hsiang Harrison W. , Girard Beatrice M. , Ratkovits Lexi , Campbell Susan E. , Vizzard Margaret A.
Published: November 2022

Interstitial cystitis/bladder pain syndrome is a chronic inflammatory pelvic pain syndrome of unknown etiology characterized by a number of lower urinary tract symptoms, including increased urinary urgency and frequency, bladder discomfort, decreased bladder capacity, and pelvic pain. While its etiology remains unknown, a large body of evidence suggests a role for changes in neurotrophin signaling, particularly that of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF). Here, we evaluated the effects of pharmacological inhibition of the NGF receptor TrkA, BDNF receptor TrkB, and pan-neurotrophin receptor p75NTR on bladder function in acute (4-hour) and chronic (8-day) mouse models of cyclophosphamide (CYP)-induced cystitis. TrkA inhibition via ARRY-954 significantly increased intermicturition interval and bladder capacity in control and acute and chronic CYP-treatment conditions. TrkB inhibition via ANA-12 significantly increased intermicturition interval and bladder capacity in acute, but not chronic, CYP-treatment conditions. Interestingly, intermicturition interval and bladder capacity significantly increased following p75NTR inhibition via LM11A-31 in the acute CYP-treatment condition, but decreased in the chronic condition, potentially due to compensatory changes in neurotrophin signaling or increased urothelial barrier dysfunction in the chronic condition. Our findings demonstrate that these receptors represent additional potent therapeutic targets in mice with cystitis and may be useful in the treatment of interstitial cystitis and other inflammatory disorders of the bladder.
A virtual reality social conditioned place preference paradigm for humans: Does trait social anxiety affect approach and avoidance of virtual agents?
Authors: Kiser Dominik P. , Gromer Daniel , Pauli Paul , Hilger Kirsten
Published: November 2022

Approach and avoidance of positive and negative social cues are fundamental to prevent isolation and ensure survival. High trait social anxiety is characterized by an avoidance of social situations and extensive avoidance is a risk factor for the development of social anxiety disorder (SAD). Therefore, experimental methods to assess social avoidance behavior in humans are essential. The social conditioned place preference (SCPP) paradigm is a well-established experimental paradigm in animal research that is used to objectively investigate social approach–avoidance mechanisms. We retranslated this paradigm for human research using virtual reality. To this end, 58 healthy adults were exposed to either a happy- or angry-looking virtual agent in a specific room, and the effects of this encounter on dwell time as well as evaluation of this room in a later test without an agent were examined. We did not observe a general SCPP effect on dwell time or ratings but discovered a moderation by trait social anxiety, in which participants with higher trait social anxiety spent less time in the room in which the angry agent was present before, suggesting that higher levels of trait social anxiety foster conditioned social avoidance. However, further studies are needed to verify this observation and substantiate an association with social anxiety disorder. We discussed the strengths, limitations, and technical implications of our paradigm for future investigations to more comprehensively understand the mechanisms involved in social anxiety and facilitate the development of new personalized treatment approaches by using virtual reality.
Early return to work: Single-port vs. multiport laparoscopic surgery for benign ovarian tumor
Authors: Tang Ying , Wen Ming-bo , Su Bin , Wang Hang , Zheng Xue-mei , Yang Ming-tao , Yin Shu , Xu Fan , Hu Hui-quan
Published: November 2022

Objective

To compare the return to work (RTW) time between single-port laparoscopic surgery (SPLS) and multiport laparoscopic surgery (MPLS) for benign ovarian tumors.

Methods

A cross-sectional cohort study was conducted, which consisted of 335 women of reproductive age with benign ovarian tumors and who were keen on returning to work as early as possible. Surgical outcomes, postoperative pain score, postoperative satisfaction with the cosmesis score (CS), and the RTW time of the SPLS group were compared with those of the MPLS group. Besides, the RTW time and CS were calculated from the questionnaire survey by a single specialized gynecologist.

Results

Women who met the inclusion criteria were included in the SPLS (n = 106) and MPLS groups (n = 229). The RTW time in the SPLS group (22.13 ± 27. 06 days) was significantly shorter than that in the MPLS group (46.08 ± 57.86 days) (P < 0.001). The multivariate Cox analysis results showed that age (HR = 0.984, 95% CI, 0.971−0.997, P = 0.020), SPLS (HR = 3.491, 95% CI, 2.422−5. 032, P < 0.001), and return to normal activity time (HR = 0.980, 95% CI, 0.961−0.998, P = 0.029) were independent factors of the RTW time.

Conclusions

SPLS may be advantageous in terms of shortening the RTW time for women with benign ovarian tumors.
Four cases report: Treatment of knee joint cartilage defects using autologous chondrocyte patch implantation
Authors: Wang Le , Li Han , Cao Yiguo , Song Cheng , Chen Qi , Hao Jun , Zhang Weiguo , Tian Kang
Published: November 2022

Introduction

Autologous chondrocyte implantation (ACI) is a crucial method for the treatment of defects in articular cartilage. However, the extant methods for the preparation of autologous chondrocyte patch are relatively complicated and money-consuming. Therefore, an efficient, reliable, easy-to-follow, and cost-effective technique is needed to overcome constraints. This case report aims to introduce an autologous chondrocyte patch fabrication technique to repair knee joint cartilage defects and report our typical cases with a 2-year follow-up.

Case presentation

We described four cases in which patients complained of knee joint pain. According to radiological examination, the patients were diagnosed as knee joint cartilage defect. Arthroscopy and autologous chondrocyte patch implantation were performed as well as a 2-year follow up of patients. The autologous chondrocyte patch for knee joint cartilage repair was fabricated using a “sandwich” technique. The preoperative and postoperative knee function was evaluated by four subjective evaluation systems. MRI was performed for all patients to achieve more intuitionistic observation of the postoperative radiological changes of defect sites. The quality of repaired tissue was evaluated by Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART). Postoperative follow-up showed improvement in clinical and MOCART scores for all patients. However, one patient complained of knee joint pain after walking for a long time or recreational activities from 12- to 18-month postoperatively. The location of pain for this patient was not in accordance with the location of cartilage defect.

Conclusion

The patients undergoing autologous chondrocyte patch implantation demonstrated clinical improvement and good quality of repaired tissue postoperatively. The procedure is an efficient and cost-effective treatment for knee joint cartilage defect in this report. In addition, patients with osteoarthritis carry the risk of a poor outcome after the procedure, and whether to have a procedure should be considered carefully.