bluuebunny/crossref_metadata_2025 huggingface dataset:
Cardiac endothelial sarcoma with hypereosinophilia of children: a case report
Authors: Zhang Wei , He Mengyuan , Wang Qiang
Published: April 2023

Cardiac malignancies in children are extremely rare and they with hypereosinophilia are rather relatively uncommon. The majority of individuals may survive over the long term even with heart tumors provided they don't have any significant symptoms and their hemodynamics are unaffected. But we should nevertheless be aware of them, especially when they are coupled with persistent hypereosinophilia and the development of a hemodynamic anomaly. The case of a malignant heart tumor with hypereosinophilia in a 13-year-old girl is presented in this paper. She exhibited an echocardiographic deficit and a heart murmur. Additionally, it was difficult to treat her hypereosinophilia. Nevertheless, it was resolved the day after the operation. We presume that there is a certain relationship between them. This study gives clinicians a wide range of options for analyzing the connections between malignancy and hypereosinophilia.
Left atrial volume by cardiac CTA prior to catheter ablation: comparison to echocardiography and association with recurrent atrial fibrillation
Authors: Alajaji Wissam , Costantini Ottorino , Taigen Tyler L. , Iler Mark A.
Published: April 2023

Objective

Left atrial volume index (LAVI) by echocardiography can be challenging and its accuracy is highly dependent on image quality. Cardiac computed tomography angiography (CTA) can overcome echocardiographic LAVI measurement challenges; however, data are limited. Therefore, we evaluated the reproducibility of LAVI by CTA, its correlation to echocardiography, and its association with recurrence of atrial fibrillation (AF) after pulmonary vein isolation (PVI) in this retrospective cohort study of patients who underwent CTA prior to PVI. LAVI was measured by CTA and echocardiography using the area length method.

Results

74 patients had echocardiography and CTA within 6 months and were included in this study. The interobserver variability of LAVI measured by CTA was low (1.2%). CTA correlated with echocardiography but found larger LAVI values by a factor of 1.6. Also, LAVI cut off of ≥ 55 ml/m2 measured by CTA correlated with recurrent AF after PVI (adjusted Odds Ratio 3.47, p = 0.033).
Surface TREM2 on circulating M-MDSCs as a novel prognostic factor for adults with treatment-naïve diffuse large B-cell lymphoma
Authors: Wang Hao-Yuan , Yang Fu-Chen , Yang Ching-Fen , Liu Yao-Chung , Ko Po-Shen , Li Chien-Jung , Tsai Chun-Kuang , Chung Yi-Lin , Chen Nien-Jung
Published: April 2023

Introduction

Circulating monocytic myeloid-derived suppressive cells (M-MDSCs) are implicated as a poor prognostic factor and cause CAR T-cell failure in diffuse large B-cell lymphoma (DLBCL). Triggering receptors expressed on myeloid cells 2 (TREM2) are a transmembrane glycoprotein that polarize macrophages to anti-inflammation phenotype but have never been explored on M-MDSCs. This study aims to elucidate the expression and clinical impact of surface TREM2 on circulating M-MDSCs derived from DLBCL adults.

Methods

This prospective, observational study enrolled 100 adults with newly diagnosed and treatment-naïve DLBCL from May 2019 to October 2021. Human circulating M-MDSCs were obtained from freshly isolated peripheral blood, and each patient’s surface-TREM2 level on M-MDSCs was normalized via a healthy control at the same performance of flow-cytometry analysis. Murine MDSCs derived from bone marrow (BM-MDSCs) were adopted to assess the link between Trem2 and cytotoxic T lymphocytes.

Results

More circulating M-MDSCs at diagnosis of DLBCL predicted worse progression-free (PFS) and overall survival (OS). Patients with higher IPI scores, bone marrow involvement, or lower absolute counts of CD4+ or CD8+ T cells in PB had significantly higher normalized TREM2 levels on M-MDSCs. Additionally, normalized TREM2 levels on M-MDSCs could be grouped into low (< 2%), medium (2–44%), or high (> 44%) levels, and a high normalized TREM2 level on M-MDSCs was proven as an independent prognostic factor for both PFS and OS via multivariate Cox regression analysis and associated with worst PFS and OS. Interestingly, normalized levels of surface TREM2 on M-MDSCs were negatively associated with absolute counts of PB CD8+ T cells and positively correlated with levels of intracellular arginase 1 (ARG1) within M-MDSCs. Wild-type BM-MDSCs had significantly higher mRNA levels of Arg1 and showed more prominent ability to suppress the proliferation of co-cultured CD8+ T cells than BM-MDSCs from Trem2 knockout mice, and the suppressive ability could be impaired by adding Arg1 inhibitors (CB1158) or supplementing L-arginine.

Conclusion

In treatment-naïve DLBCL adults, a high surface-TREM2 level on circulating M-MDSCs is a poor prognostic factor for both PFS and OS and warrants further investigation for its potential as a novel target in immunotherapy.
Surgery versus antibiotics in pyocele: a case report
Authors: Hussain Hussain , Fadel Aya , Garcia Efrain , Saadoon Zahraa F. , Balaji Adith , Mendez Luis , Snan Mhd Ali , Angly Sohair , Jayakumar Arumugam R.
Published: April 2023

Background

Epididymitis has several etiologies that can be related to infectious and non-infectious causes, autoimmune conditions, aseptic causes, and even certain pharmaceutical medications (amiodarone and chemotherapeutic agents). Some cases of epididymitis are complicated with pyocele formation that requires emergent surgical intervention to prevent testicular gangrene. This report describes the case of a 66-year-old male who developed severe bilateral epididymitis complicated by bilateral pyocele and ensuing sepsis. Astonishingly, the condition resolved completely without surgical intervention.

Case presentation

We are presenting a case of a non-sexually active male who developed bilateral severe epididymitis complicated by pyocele that led to the development of septic shock. Further history revealed that the patient was not sexually active with male or female partners and denied any form of trauma. Physical examination demonstrated scrotal swelling and erythema on inspection and severe tenderness on palpation. Digital rectal examination as well as abdominal examinations was unremarkable. Laboratory investigations disclosed severe leukocytosis with a neutrophil predominance (39,000 K/UL, normal range 4500–11,000 K/UL), as well as an elevation of systemic inflammatory markers such as erythrocyte sedimentation rate and C-reactive protein. Urine culture was positive for Escherichia coli. Ultrasound revealed bilateral epididymitis and pyocele. This patient was managed with a course of meropenem, resolving the epididymitis and pyocele without the need of surgical intervention.

Conclusions

Surgical intervention is considered the standard of care and the approved management for pyocele to avoid further complications such as Fournier’s gangrene. However, this patient was treated solely with antibiotics, and his condition was stabilized without the need of surgical intervention that would result in additional cost and length of stay for the patient. This case raises further questions regarding the potentially better bioavailability of this antibiotic in the scrotum compared to elsewhere in the body and the potential for a non-surgical alternative approach in the management of patients with pyocele and requires further research.
Rearranging the Bird’s Nest Fungi: molecular review of internal clades in Cyathus (Nidulariaceae, Basidiomycota)
Authors: da Cruz Rhudson Henrique Santos Ferreira , dos Santos Góis Jefferson , Marinho Paulo , Baseia Iuri Goulart , Hosaka Kentaro
Published: April 2023

The genus Cyathus was established in 1768, but more in-depth taxonomic studies with the group only occurred after 1844. In the following years, changes in the infrageneric classification of Cyathus were proposed based mainly on morphology. With advances in phylogenetic studies, the morphological classifications were tested and a new subdivision into three groups was proposed in 2007. Based on the last two classifications, this work aims to expand and understand the internal phylogenetic relationships among the fungi of the genus Cyathus and examine how these relationships are reflected in the taxonomic classification, through molecular analyses covering most of the species in the group, based on materials obtained from type specimens deposited in major fungal collections worldwide, besides expanding sampling with tropical species. Molecular analyses followed the protocols available in the literature, including the design of specific primers for Cyathus. In the phylogenetic analysis, using Maximum Parsimony and Bayesian methods, sequences of ITS and LSU regions from 41 samples of 39 species of Cyathus, 26 were placed with some nomenclatural types. The monophyly of Cyathus was confirmed with maximum support in both tests, and the infrageneric groups of the most recent classification were unchanged, but the clade striatum showed segregation into four groups and three subgroups. The phylogenetic organization is supported morphological characters, and diagnoses are presented for each group, as well as a dichotomous key for the infrageneric separation.
RUINS NARRATE THE HISTORY OF THE ISLET OF AGIOS GEORGIOS IN SALAMIS THROUH A CULTURE ROUTE
Authors: Delazanou Maria Athanasios
Published: April 2023

This paper deals with ruins and deliberate abandonment, through the “experience” of a cultural route that will bring back memories from the dark pages of history, where “mourning” awakens social consciences so that, future generations can have a better future. The research took place in the islet of Agios Georgios, in historic Salamis. Rich photographic material captures a haunted landscape that through its endless silence, the echo of the wilderness is heard,   whispering towards Perama and Paloukia,   unknown stories of people who lived, were abandoned and left their last breath there.The proposed cultural route consists of nine thematic stops, which narrate the daily routine in a lazaretto quarantine island. Each stop connects the ruins with their past. Each building illustrates traumatic memories contributing to an interpretation of our history, highlighting and raising awareness of the character of this dark heritage. The ultimate goal and vision of this cultural route is to be included in the tourist map of Greece, inspiring respect, not only for the martyrdom events but also for the natural and architectural landscape of the islet of Agios Georgios.
THE EVOLUTION OF THE GRAPHICAL USER INTERFACE: FROM SKEUOMORPHISM TO MATERIAL DESIGN
Authors: Gatsou Chrysoula , Farrington John Steven
Published: April 2023

Graphical user interfaces are an evolution of the command line user interfaces of the past. Graphical user interfaces allow users to interact with devices while using the metaphor of a desktop surface. As technology evolved, user interfaces became more elaborate, going through various design phases such as skeuomorphism and modern, flat design. User interfaces have become more simplified and use fewer non-essential design elements. This also allows for easier cross-platform development.  Due to the widespread adoption of technology, clear user interfaces that put usability first, have and will become very important in the years to come. We present the very beginnings of the GUI, its evolution through the years and finally focus on modern graphical user interfaces while also going over various problems
ABSTRACT ART IN GREECE: THE PIONEER ARCHITECTS
Authors: Sarakatsianou Vasiliki
Published: April 2023

The early years of the 20th century is a period of deep intellectual reappraisal as well as social and intellectual change. The modern painters’ experiments have come right to the forefront of artistic attention. Modernism was the point when the idea of radical and innovating arts, the experimental, technical, aesthetic idea reached a formal crisis, leading to abstract art. Modernism predicates the origins of post-war art as Post-Modernism adds to the abundance of versions of Modernism. After World War II abstract expressionism achieved international influence.On the contrary, in Greece during the first half of the 20th century, abstract art was absent.  It actually appeared in the 1950s but it became dominant in the 1960s. In the post-war period, there were many talented Greek architects such as, Marthas, Xenakis, Proveleggios, Tsingos, Fatouros who became interested in painting, following the contemporary art tendencies. This paper focuses on abstract painting in Greece both in the early years of the 20th century as well as in the 1950s and 1960s. In this context, the contribution of Greek architects as pioneer visual artists in the 1950s and 1960s to the gradual establishment of abstract painting in Greece is probed, using as a methodological tool mainly artworks and written sources of that period. It is argued that Greek architects with their artworks and their wide range of activities in the field of visual arts express the modern consciousness and pave the way for abstract art in Greece.
THE SECOND LIFE OF EVERYDAY OBJECTS IN BARRY FELDMAN’S WORK
Authors: Kertemelidou Paraskevi , Warner Randall
Published: April 2023

The following text makes special reference to the transfer of common industrial objects from the category of utility or even waste to autonomous works of art. The concept and image of the industrial object as garbage, by-product or as a thing without value, has occupied the artists of Cubism, Dada, Pop Art, Fluxus and Conceptual Art more recently (Cornell, Schwitters, Duchamp, Arman, Rauschenberg, Oldenburg, among many others). Barry Feldman, a New York artist and art historian, discovered through the permanent collection of MoMA avant-garde art and when he moved to Greece his New York experience remained alive for his work. Every industrial object finds its place in some of his three-dimensional compositions which he categorizes as boxes, portables, portholes and rockets. In wooden boxes, old or made by him, the worthless objects of our world are recycled and return to their autonomous existence.
LIGHT FROM BELOW
Authors: Samuelsen Geir Harald
Published: April 2023

The light is shining from the ground, minutes after the sun has set. The Fontainebleau sand is glowing with a mysterious light from below. I prepare for the camera to capture it. If it does, it will capture the disappearing sun shining in the bright surface of the sand.
FRAGMENTS OF MEMORY IN RESIDENTIAL INTERIOR ARCHITECTURE
Authors: Martha Loukia
Published: April 2023

The present paper tackles the concept of memory as a compositional tool employed in the architectural spatialization process. More specifically, it focuses on residential interior architecture in the work of Greek architect Takis Marthas, placing special emphasis on the conjunction of tradition and Modernism, a binary vividly captured in the architecture and visual arts of the 1930s, to which Marthas belongs. In Marthas’ oeuvre, design and composition are locked in a dialectical relationship by way of cross-pollination, juxtaposition, complementarity, or the introduction of intact fragments of memory into space. Marthas’ architectural style could thus be construed as an attempt of combining the past and the present in the form of a creative process whereby elements–mental or material–are drawn from diverse places and historical periods, only to be repurposed and integrated into a unified whole, retaining their autonomy and alluding to a hybrid architectural model. As far as the composition of the residence is concerned, memory is conveyed through images of the past rendered either as an integral spatial transfer or as mental and material architectural constructions, material elements, textures and colour. These spatial elements evoke and restore images and sensations of the past. Within the architectural creation of the residence, compositional gestures linked with memory can be freely expressed, connecting the past and the present, architecture and place, as well as bringing together the space and users/residents’ personal experiences. Fraught with a number of tensions typical of the 1930s generation, such as the abovementioned attempt to bring together the past and the present, but also to pursue Greekness through both references to antiquity and references to Greek folklore tradition, Marthas’ oeuvre is adumbrated by using residential works as well as written and oral testimonies dating from the 1930s-1960s as methodological tools.
(HI)STORIES
Authors: Berriet Margalit
Published: April 2023

The purpose of this paper is to journey through the world of abstract signs, symbols, and images, in an attempt to comprehend the process of constitution of memories, of (hi)stories, of dialects, and of (super)natural realities, as generated by human perceptions of things. Sensitivity and intuition in the process of recording impressions of spaces and places, of nature and of objects, are integral parts of the process of generating and storing memories, shaping associations, and fashioning the storylines that compose our (hi)stories. These are also the sources for comprehending the process by which the mind produces images and other means of communication inventing signs and symbols, composing messages, languages, technologies, and arts. The need to leave a trace is instinctive. Human beings are defined by their capacities to observe, propose ideas, defend hypotheses, and prove objectives. Artistic images and creations, from pre-history to today, convey thoughts, facts, and memories, making the incredible diversity of the human spirit visible. All human actions are based upon cultural, social, and ethical constructions of knowledge, interpretations, awareness, and of engagements. Arts and cultures, then, are mirrors of the journey of civilization, reflecting on the entirety of its expeditions and productions. Imagery and metaphor connect people, continents, philosophies, beliefs, (hi)stories. Languages and arts transcend locations and personal differences, illustrating and enhancing the understanding of realities, ethics, and aesthetics. Nowhere on earth do people exist without language, art, or culture.
PROJECT SPINOZA: RE/MEMBERING SENSORIAL COGENCY – (Part one)
Authors: Barth Theodor
Published: April 2023

The purpose of this article is to present a research portfolio – composed of an online archive and an index from 2020-22 – and perform its outcomes in a memory-theatre. The design needed for this theatre is modelled on Baruch Spinoza’s Ethica, in which the order of a geometrical demonstration hosts a philosophical investigation. The non-same rules/ heteronomy of the host and the guest, in Spinoza’s opus magnum, is an instance of a wider phenomenon which the article seeks to explore and exploit: the docking of an investigation, by the means of a contraption that is foreign to it, intercepting images of what the present may have in store (whether past, present, or future). The sensorial cogency that picks up on elements it can comprehend, but never fully contain: the mnemonic slippery nature of the image. On this backdrop, the article discusses different ways of pairing up with the environment, through media that are hosted rather than belonging there: the different terms of populating the present, being together or forming a group, serve to elucidate certain aspects of memory – mnemonic devices with an environmental footprint – in fieldwork, laboratory research, digital culture or presently the electrosphere. The article thereby seeks to develop and propose some designs to work with the problem of interception – picking up changes in the ‘memory of the present’ (Bergson, 2021): what it holds and what it has in store. The article seeks to establish a parity between apparatuses with such impact, in view of comparing them: whether they are as simple as 1) a post in a hole (a datum), or more complex as 2) a computer docked to a home-office (another datum). In the presentation of the portfolio, a framework for partaking of such changes, compiling the experience prompted by them, is proposed (Benjamin, 1999). The major feature of this framework is then deepened in a situated case-study: here, positions coexisting and valued on different terms, in the presence of a cabin in reconstruction, shift as they are logged in a guest book. In a section on design, the article probes a broader applicability of what has been found in the case-study, based on a wider fieldwork experience. Principle: repair also writes re-pair. In the conclusion, a design for a ‘contemporary interception’ is demonstrated visually.  The anthroponomical framework is conceived as a scholarly contribution to art, and an artistic contribution to science, through a mnemonic understanding of the technical image.
PETER DOIG’S ART AS A SIGNIFICATION OF THE RE-APPEARANCE OF THE SUBLIME IN CONTEMPORARY BRITISH LANDSCAPE PAINTING
Authors: Tzanetoulakou Eftychia
Published: April 2023

Purpose: The core of this research is the multi-layered and diverse presence of the Sublime in art today, as analysed through the oeuvre of Peter Doig, the contemporary British painter who belongs to the stream of the Young British Artists, which was developed in Great Britain in the 1990s. Topic: The present research begins with the definition of the idea of the Sublime and continues with a historical review of its manifestations in British art. Peter Doig is chosen because it is a suitable field of research into the current image of the Sublime. Methodology: Peter Doig’s work will be thoroughly examined so that the above view can be demonstrated, through a critical analysis of his paintings, and the similarities and differences with the powerful landscape painting of the 19th-century Romanticism that filled the viewer with awe and fear. Doig translates this artistic knowledge into a peculiar, internally experienced image-making that acrobats on the fringes of the established structures of artistic composition, attempting to portray the unpresentable, the timeless, the transcendent, the ambiguous, the illusory, the after-human elements that construct the landscape of Today. The selected works’ analysis is based on the immediacy of representation as an independent carrier of energy of human experience, which leads the artist to re-use the medium of painting. The research continues by examining, through its painting techniques but also via his use of photography and ready-made postcards, the ways in which the artist uses the materiality of the medium to test how the seemingly closed boundaries of representation expand into many fields of feeling, reading and understanding a timeless Now. Result: The research concludes with critical predictions about the directions and the position that the notion of the Sublime may take, starting from the creative codes in the work of Peter Doig. The paper does not seek to build a position based on unshakable, definitive and non-negotiable conclusions, but to constitute an original and thorough academic springboard, with poetic coordinates of aesthetic consideration, in the research on the applications of the painterly Sublime today.
SOMNIFERA
Authors: Sørensen Elin Tanding
Published: April 2023

“Somnifera” explores interactions between the opium poppy and humans. In their exploration of new habitats, human tribes curiously tested out plants that could help them transcend their “normal” state into expanded experiences, possibly communicating with their ancestors or gods, as part of their experimental quest for knowledge. Since the dawn of time, we have milked the benefits of the opium plant, while politics, religion, and a cynical multinational drug and pharmaceutical industry have assigned the plant a controversial role on the world stage. The plant’s power to both save life and take life is the essence of this artwork with the intention to contribute to a holistic debate about the opium poppy’s potential: To lift it out of the shadow of condemnation and give it its rightful bright place among us. This narrative dips in and out between trance-states and every-day-states-of-mind, while the author’s alter ego Sigma Woman enters love and grief – transitioning from emotional breakdown to possible healing. The figurative language of this text, and its accompanying images, are from visions emerging from ecstatic trance – described as the primaeval technique of a safe, natural physiological transition to direct experience of the eternal now and ancestral wisdom. In one of the trance-sessions we concentrated on the three-thousand-year-old figurine “The Poppy Goddess and Patron of Healing.” This inner journey gave rise to the idea of exploring reenactment, inspired by experimental archaeology.  Approaching the goddess figure, the author anoints her body with Caput Mortuum-colored oxidized magnetite, adorns herself with poppy capsules, and mimics the statue’s apparent hibernation. In the attempts to find “surfaces of contact” between today’s imaginary world and prehistoric times – through speculation whether we and our ancestors can “meet” in some way – the methods used to develop the artwork range from knowledge acquisition through scientific papers to techniques for embodying knowledge. As part of the artistic research project Matter, Gesture and Soul (MGS), which seeks encounters and alignments between art and archaeology, my artistic contribution seeks to question how multispecies storytelling may connect us emotionally to our ancient distant past.
STONES, WORDS, IMAGES
Authors: Radu Lilea Mabe Bethônico  and
Published: April 2023

Cultural memory, as viewed by historian Alexander Etkind, influenced by the world of computers, from where he takes this blatant yet effective reference, is binary: there is a “soft memory” preserved mostly in texts, and a “hard memory” stored primarily in monuments (Etkind, 2013, p. 177). His perspective on how cultural memory crystallizes, functions and then moulds people’s lives and communities was laid out in a study devoted to Soviet cultural heritage, particularly to those memorial practices engendered by an unburied past which always seems to be resurfacing. It is precisely this way of understanding memory, as an interconnected system whose parts can only work together, that can be further applied beyond the cultural space presented in Etkind’s book. This is, in fact, quite obvious in the works of Mabe Bethônico, a Brazilian visual artist which brought to my mind this insightful way of perceiving cultural memory. Her art projects explore and probe into the veins descending deep into both her country’s past and the earth’s belly – historical and geological veins that, under contemplation, take on more than just a literal meaning. They acquire, simultaneously, new metaphorical and universal interpretations, rendering the artist’s work extremely relevant outside the immediate Brazilian context. Mabe Bethônico’s artistic practice operates in this fuzzy elusive space, where soft and hard memory meet and converge. Her art successfully turns narratives around, fills voids and uncovers histories that have been silently living among us. The text below is based on an interview she kindly gave us. Nevertheless, for the sake of brevity and to observe the formality of the Portfolio section, we have turned the questions into themes. Therefore, this is the artist’s ‘curated’ testimony that, in a different setting, would most likely have taken a different form.
MEMORY AND OBLIVION: TANGIBLE IMAGES AND UTOPIA
Authors: Oosterbeek Luiz
Published: April 2023

The thesis of W. Benjamin on the concept of History echoes as almost an anti-postmodernism manifesto: the approach to the past is structured through images, not narratives. Indeed, in the tension between history (the universal past rooted in agreed replicable methodologies for a human archetype) and memory (the ego or sociocentric past rooted in individual experiences), egos design narratives and try to fit evidence into them, whereas the historical past is constantly reconstructed through zooming in details that generate new images. The image in history, as the mental image in individuals, is not a layer of arrival, nor even a point of departure, but a vehicle of transformation of how space is perceived (as Kant argued) or constructed (following Bachelard), the phenomenological process of performing tasks in space being the driver of such construction (as argued by Ingold). The design of history through images is, in this sense, the process of social construction of cultural landscapes, i.e., of the poetics of space. This is a process that encompasses four mechanisms of change: identification (based on senses and, primarily, on touch and sound), adaptation (the Kantian perception of the space as the scenario of human aptitude), transformation (the poetics of the making, creating new landscapes by changing their core images) and method (namely the dialectics of tangible and intangible dimensions). The tension between image and narrative is, ultimately, the root of the tension between ego/socio-centered memories and the anthropic-rational history. In such a process, history builds from memories, by overcoming their narratives and preserving basic units of information that may be recombined, to create novel images of the past, but also of the present and the future. In such a process, history considers memory oblivion and an indicator of reliability or not of those memories. In this paper we discuss how material culture is the backbone of mental images and why it has a much more plastic and transformative nature than intangible narratives, which are expressions of the consolidation (and conservation) of understandings. The keyword in such a memory process is oblivion: images allow us to forget fossil narratives and to move into new utopias.
M[EMOR]YTH
Authors: Clondir Razvan
Published: April 2023

The visual experiment proposed by my portfolio is the result of current technologies integrated into the creative process. Using mobile devices, I capture static or video images, I record sounds. I can locate and set a multitude of technical parameters of the collected multimedia material; I can precisely locate the place where I take them. In the experiment, which I called “open work”, I used all the technology-mediated information to create an application that would infinitely assemble the digital material input in order to create collages or fragments of physical space through digital memory. Anyone can input the digital materials obtained in the same location in the application, each contribution is a personal vision of the place. This portfolio is one of the many artistic outcomes of the experiment.
Ιονισμός της ατμόσφαιρας της Γης από τις κοσμικές ακτίνες
Authors: Μακραντώνη Παναγιώτα
Published: April 2023

Η κοσμική ακτινοβολία αποτελεί βασικό παράγοντα του ιονισμού της ατμόσφαιρας της Γης. Τόσο οι ηλιακές όσο και οι γαλαξιακές κοσμικές ακτίνες, οι οποίες εξαρτώνται από την ηλιακή δραστηριότητα και το γεωμαγνητικό πεδίο, επηρεάζουν την έκθεση στην ακτινοβολία στην ατμόσφαιρα. Έχουν δημιουργηθεί αρκετά μοντέλα για τον υπολογισμό του ιονισμού και των δόσεων ακτινοβολίας. Στην παρούσα διατριβή, όσον αφορά τους υπολογισμούς του ρυθμού ιονισμού (CRII) χρησιμοποιήθηκε το μοντέλο CRAC:CRII του Πανεπιστημίου της Oulu της Φιλανδίας, ενώ για τον υπολογισμό του ρυθμού ισοδύναμης δόσης περιβάλλοντος (dH*(10)/dt) χρησιμοποιήθηκε το λογισμικό DYASTIMA/DYASTIMA-R του Πανεπιστημίου Αθηνών. Και τα δύο εργαλεία είναι πολύ σημαντικά καθώς μας επιτρέπουν να υπολογίζουμε τα αντίστοιχα φυσικά μεγέθη σε όλη τη Γη, σε ολόκληρη την ατμόσφαιρα και για διάφορες χρονικές περιόδους και φάσεις του ηλιακού κύκλου. Η συνδυαστική μελέτη αφορά τους δύο τελευταίους ηλιακούς κύκλους 23 και 24 (1996–2019) και συγκεκριμένα επίπεδα πτήσης της εμπορικής αεροπλοΐας (FL310, FL350 και FL390). Η εξάρτηση των CRII και dH*(10)/dt από τη γεωμαγνητική δυσκαμψία, την ηλιακή δραστηριότητα, την ένταση της κοσμικής ακτινοβολίας, καθώς και το υψόμετρο εντός της ατμόσφαιρας, επηρεάζουν την έκθεση στην ακτινοβολία των μελών του πληρώματος των αεροπλάνων και των συχνών επιβατών, καθώς και τα ηλεκτρονικά συστήματα των αεροσκαφών, γεγονός που κάνει τα αποτελέσματα πολύ ενδιαφέροντα για την αεροπορική βιομηχανία.
Osteogenic sarcoma - clinical cases in the practice of a children's orthopedist and surgeon
Authors: Protsailo M. , Dzhyvak V. , Krycky I. , Hoshchynskyi P. , Gerasymets Yu.
Published: April 2023

Despite the significant achievements of modern medical science, oncological diseases pose great difficulties regarding the etiology, timely diagnosis, treatment and prevention of these ailments. Early diagnosis of tumors is the main task facing doctors. Our clinical observations over the past 5 years have shown that all children with tumors sought medical help late with advanced forms. Therefore, our task is to convey to a wide range of pediatric specialists, and not only, information that will help to recognize tumors as early as possible. Time is of crucial importance - whether the child will live or not. The given typical clinical cases should alert you to the recognition of tumors. Unfortunately, the markers of osteogenic sarcoma have not been developed at the moment, so clinical signs play an extremely important role in recognizing this disease.
Traffic Risk Image in The Light of the Road Situation Assessment Questionnaire
Authors: Horoszkiewicz Krzysztof , Cibor Ryszard , Horoszkiewicz Bartosz
Published: April 2023

Introduction: Drivers often lack reflection on their behaviour. For predictive purposes and educational interventions, it is useful to know the individual traffic risk picture of the driver under investigation.

Objective: This paper aimed to show the psychometric properties of the questionnaire and to establish a hierarchy of traffic situations in terms of perceptions of associated danger.

Material and Methods: A total of 548 people aged between 18 and 68 years participated in the study. A self-administered questionnaire method was used to measure situational (road) awareness and the ability to anticipate the consequences of engaging in unsafe road traffic actions. The tool's accuracy was verified with the 'Controversy' questionnaire, which is used to measure the severity of drivers' normative beliefs about breaking traffic laws.

Results: Satisfactory psychometric values of the questionnaire were obtained. After taking into account the correlation of measurement errors, an acceptable fit was obtained: χ2 /df = 2.48; GFI = 0.95; AGFI = 0.92; CFI = 0.96; RMSEA = 0.06 (0.048-0.072). Mean values and standard deviations for 14 descriptions of unsafe traffic situations were shown.

Conclusions: The satisfactory reliability and accuracy of the measurement allow the method to be used in research and individual diagnosis in the areas of transport psychology and education. Overtaking at pedestrian crossings, on a bend, uphill, and continuing to drive despite fatigue are the most dangerous traffic situations associated with the risk of traffic accidents.
Mühlen, Gärten, Ochsen und „Lustbarkeit”
Authors: Scheutz Martin
Published: April 2023

The relationship between the walled city and the suburbs was difficult and complex. Sometimes the suburbs were included in the division of the core city into city districts, sometimes the suburbs were districts in their own right. Thus, the suburbs were both a connecting and a dividing element. Based on the naming of the suburbs, the article also attempts to draw conclusions about the functions of these districts for the city as a whole: city gates, trade relations, trading orientation, but also confessional criteria were important for the naming. The suburbs were used multifunctionally by various actors, the city itself, but also the sovereign or monasteries appear as actors: Leprosoriums and hospitals were found there, the multifunctional fairground, but also monasteries were settled there. The suburb was also important for military defence - the former “glacis” later often turned into a city park or was densely built up. But the suburb was also a place of leisure culture, fireworks and inns, but also increased crime had their place there.
Korespondencja urzędników folwarcznych Marianny z Kątskich Potockiej, starościny lwowskiej jako przyczynek do analizy podstaw życia ekonomicznego dworu w czasach saskich
Authors: Kicińska Urszula
Published: April 2023

Maria z Kątskich Potocka (zm. 1768), starościna lwowska to postać nietuzinkowa, dziedziczka ogromnej fortuny po Kątskich, Denhoffach i Szczukach, która stała się podstawą późniejszej potęgi ekonomicznej rodu Potockich. Jak dotąd niewiele wiadomo na temat zaangażowania się generałowej w działalność ekonomiczną i zabiegi mające na celu dopilnowanie i pomnożenie rodzinnego majątku. Refleksje te przynosi analizowana korespondencja urzędników folwarcznych, która pozwala wniknąć w środowisko dworu Potockich, oraz poznać sposób jego administrowania. Ukazuje ona również relacje pomiędzy dobrodziejką a jej poddanymi, oraz wskazuje główne dziedziny jej aktywności gospodarczej.
Organizacja, przebieg i skutki realizacji polityki władz partyjno-państwowych przeciw rekolekcjom szkolnych w 1952 roku.
Authors: Mercik Joanna
Published: April 2023

W artykule omówiono kwestię organizacji, przebiegu i skutków realizacji polityki władz partyjno-państwowych przeciw rekolekcjom szkolnym organizowanym w 1952 r. Władza uznała je za wskaźnik postępu walki z Kościołem i zleciła drobiazgowe kontrole terenowe.  Na podstawie analizy materiałów archiwalnych i dostępnej literatury autorka przedstawiła metody i środki stosowane przez państwo w celu osiągnięcia sukcesu. Problem ten przedstawiony jest w kilku obszarach szkoły, nauczycieli, uczniów, rodziców a także duchowieństwa. Takie całościowe spojrzenie pozwoliło ocenić następstwa przeprowadzonej akcji.
Marta Kuc-Czerep, Niemieckojęzyczni mieszkańcy Warszawy. Droga do obywatelstwa w osiemnastowiecznej Rzeczypospolitej, Wydawnictwo Instytutu Historii Polskiej Akademii Nauk, 2021, ss. 444 + mapa.
Authors: Baranowska Marta , Fiktus Paweł
Published: April 2023

Recenzja książki.
On Some Meta-Theoretic Topological Features of the Region Connection Calculus
Authors: Gan Nathaniel
Published: April 2023

This paper examines several intended topological features of the Region Connection Calculus (RCC) and argues that they are either underdetermined by the formal theory or given by the complement axiom. Conditions are identified under which the axioms of RCC are satisfied in topological models under various set restrictions. The results generalise previous results in the literature to non-strict topological models and across possible interpretations of connection. It is shown that the intended interpretation of connection and the alignment of self-connection with topological connection are underdetermined by the axioms of RCC, which suggests that additional axioms are necessary to secure these features. It is also argued that the complement axiom gives RCC models much of their topological structure. In particular, the incompatibility of RCC with interiors is argued to be given by the complement axiom.
The Relationship of Screen Exposure with Sleep Quality and Self-Regulation Skills in Preschool Children
Authors: ÖZDEMİR Çağla , KELEŞ Süleyman
Published: April 2023

Objective: We aimed to investigate possible links between screen time, self-regulation skills and sleep quality in preschool children.

Material and Methods: The study was carried out with 140 mothers with 4-6 years old children who visited the family medicine outpatient clinic between March and May 2022. Children’s age, gender, existing chronic diseases, the most used technological product, purpose of use, time and duration were recorded. Children’s sleep habits were evaluated with the “Children’s Sleep Habits Questionnaire (CSHQ)”, and their self-regulation skills were evaluated with the “Self-Regulation Skills Scale for 4-6 Years-Old Children(Mother Form)(SrSS)”.

Results: The median age of the children in our study was 60 (48-72) months. 75/140 of the participants were girls. The most used technological product at home was the smartphone (48.2%). 64% of the participants reported less than 2 hours screen time, 21.6% of them reported between 2-4 hours and 14.4% of them reported over 4 hours. Educational status of mothers (p=0.003) and fathers (p<0.001) of those with a lot of screen exposure was lower. Delay in falling asleep score, one of the CSHQ subscales, was higher in those with screen exposure over 4 hours (p<0.001). Self-regulation skills scale total score (p=0.001), attention (p=0.014), inhibitory control-emotion (p=0.004), and inhibitory control-behavior (p=0.029) sub-scale scores were lower in children with longer screen time.

Conclusion: Excessive screen exposure in preschool children is associated with delay in falling asleep and low self-regulation skills.
Staff preparedness is key to successful change in the NHS
Authors: Chowthi-Williams Annette
Published: April 2023

Annette Chowthi-Williams, Senior Lecturer, University of Roehampton ( A.Chowthi-Williams@roehampton.ac.uk )
UK Vessel Health and Preservation Framework 2020: a users’ survey
Authors: Hallam Carole , Griffin Hannah , Weston Valya
Published: April 2023

The review and update of the UK Vessel Health and Preservation Framework 2020 (VHP2020) was undertaken by a working group that included members of the Infection Prevention Society, the Royal College of Nursing, the National Infusion and Vascular Access Society and the Medusa Advisory Board and was launched in 2020. The VHP working group developed a survey to understand whether the VHP2020 had reached its intended audience, and what respondents thought were the benefits and drawbacks of its use in practice. Although the survey response was lower than expected, the responses received were largely positive and have provided feedback on how the VHP2020 is being used and some of the benefits. Most importantly, the survey has highlighted the need to communicate the benefits of the framework more effectively to reach a wider audience.
Wheely Good?
Authors: Vollans Caroline
Published: April 2023

Whether or not to use bikes at early years settings is the subject of some debate, finds Caroline Vollans
Take a Moment
Authors: Asquith Sue
Published: April 2023

How can settings make sure that they are providing ‘teachable moments’ for the benefit of children's development? By Sue Asquith
Loud and Clear
Authors: Dunkley India
Published: April 2023

It is increasingly important that bilingual and multilingual children are supported and celebrated in early years settings. Nursery World and Polylino brought together a panel of experts to discuss strategies for best practice. By India Dunkley
Be on Alert
Authors: Rawstrone Annette
Published: April 2023

What do early years settings need to know about cyber security, and how can they avoid being the victim of digital crime? Annette Rawstrone reports
Treatment of Class Ii Malocclusion with Klammt Appliance: Clinical Case Report
Authors: Borja de Melo Téssia Richelly Nóbrega , Souza Filho João Paz De , Guimarães Raquel da Silva
Published: April 2023

Objective: to report a clinical case of a young patient with Class II malocclusion, treated with the Klammt II Elastic Activator device, emphasizing the benefits of early treatment through Facial Jaw Orthopedics.

Case Report: patient G.N.S., Class II division 1, female, caucasian, Brazilian, 10 years and 10 months old, with good oral health, mixed breathing and onychophagia, attended the teaching clinic of UNIFIP/ Brazil, for orthodontic treatment due to aesthetic dissatisfaction. After clinical evaluation and radiographic and cephalometric examinations, a Class II, division 1 malocclusion with retruded mandible was diagnosed. The Klammt II functional orthopedic appliance was prescribed, with full use, for a period of 12 months and bimonthly appointments. The evolution of the case was satisfactory, with mandibular advancement and satisfactory change in the patient's facial profile.

Conclusion: it is concluded that the Klammt II open elastic activator minimized the damage caused by class II division 1 with mandibular retrognathism, redirecting the growth of the mandible in a functional way, thus generating psychological benefits and favorable aesthetics for the profile and facial proportionality.
Deciphering the Analysis of the Genetic Diversity of Mangosteen (Garcinia mangostana L.) from Various Regions of Origin in Java, Indonesia
Authors: Susilo Susilo
Published: April 2023

ABSTRACT: The genetic improvement of a plant to produce high-yielding varieties depends on genetic variability. It is widely known that the mangosteen plant (Garcinia mangostana L.) does not have genetic variability because it has an apomictic reproductive mechanism. Analysis of genetic diversity can be carried out by analysis of similarities and clusters between accessions of plants or with their close relatives of the Garcinia genus. This research was carried out to analyze the genetic diversity of 50 mangosteen accessions at mangosteen production centers in four provinces in Java, Indonesia (Banten, West Java, Central Java, and East Java provinces) using RAPD-based primers. RAPD-based amplification revealed a total of 30 amplicons, 28 as polymorphic and two as monomorphic, with an average percentage of polymorphism of 72.22%. The results of PCR-RAPD visualization produce bands measuring 300 bp - 1500 bp. The dendrogram shows the grouping of all types of G. mangostana L. in general. The primer used can amplify the samples properly. Genetic variation occurs with coefficient values ranging from 25% to 100%. This study also explains the pattern of the spread of G. mangostana L. in Java for the first time. These results can be used as a reference for conserving G. mangostana L. and future breeding.
Multipotential Secondary Metabolites from Nocardiopsis dassonovillei of Marine Actinomycetes and their In Silico studies
Authors: Kumar K. Dinesh , J. Vigneshwari J. Vigneshwari , A. Gnanasekaran A. Gnanasekaran , V. Selvamani V. Selvamani , Senthilkumar P. K.
Published: April 2023

ABSTRACT: Actinomycetes are one of the important secondary metabolite producers. Researchers focused on the exclusive marine areas for isolation and identification of marine actinomycetes. The present study focused on the isolation and identification of Nocardiopsis dassonovillei (ON627850) from TS Pettai region. The potential strainTSP1 showed effective antibacterial activity against Haemophilus influenza. TSP1 isolates showed IC50 value of 75.22 μg/ml effective antioxidant activity determined by DPPH assay. Cytotoxicity assay results were noted for the ethyl acetate extract of TSP1 screened against oral cancer cell lines (KB). The spectral characterization studies of UV, FT-IR and GC-MS results identified the compound 2,4-di-tert-butylphenol. The multi-potential 2,4-di-tert-butylphenol compound finally docked with KB cell lines protein for drug discoveries.
Influence of Aquatic Extracts and Essential Oils Obtained from Some Plants to the Growth of Toxigenic Fungi
Authors: Muradov Panah Z. , Bakshaliyeva Konul F. , Gulahmedov Saib G. , Mammadova Mehriban Y. , Ismayilova Gunay E. , Yusifova Anaghanim A.
Published: April 2023

Were investigated aquatic extracts and essential oils obtained from some plants (Agropyrum repens L, Apium graveolens L., Artemisia absinthium L., Mentha piperita L.) included in the flora of Azerbaijan on the growth of toxigenic fungi. It was determined that both materials obtained from the studied plants affects on the growth of toxigenic fungi. Although the effects of aqueous extract are fungistatic, the effects of essential oils are characterized as fungicidal activity. In the case of adding 0.01% of essential oil obtained from the Mentha piperita L. to the medium, the growth of all toxigenic fungi stops. This allowed us to note that the use of preparation obtained from same plant against of toxigenic fungi in the future is respectively.