bluuebunny/crossref_metadata_2025 huggingface dataset:
Methodology to favour the assimilation of theorems
Authors: Armando Morales Carballo  , Edgardo Locia Espinoza  , Melvis Ramírez Barragán  , And José María Sigarreta Almira
Published: July 2020

In this investigation, a methodology based on Social Constructivism is proposed to favor the assimilation of theorems through the process of Problem Solving in the students of the Higher Technical University level of the Autonomous University of Guerrero, Mexico. The theoretical-qualitative validation of the methodology was carried out by consulting experts who contributed to systematize the link between the theory and the methodological elements and its implication in the design of specific activities for the treatment of the theorem of variable change.
Análisis de la satisfacción personal en mayores con el uso y aprendizaje tecnológico en redes sociales
Authors: Fernández Martín Eugenia , Aranda Garrido Lourdes , Aranda Garrido Lourdes
Published: July 2020

En la actualidad, cada vez es más importante el uso de las Tecnologías de la Información y la Comunicación (TIC) en la vida cotidiana de las personas. No obstante, los mayores de 60 años de edad, suelen representar un porcentaje minoritario en cuanto a la utilización de estas herramientas. Por otro lado, el uso de las mismas, como facilitador de acceso a redes sociales, es un factor muy importante para estar en contacto y relacionarse con un grupo social a pesar de las limitaciones de tiempo y espacio. Por tanto, en este sentido, podría considerarse una herramienta útil para el bienestar personal y social de estas personas. De ahí surge la necesidad de este estudio.

El objetivo de esta investigación se centra en analizar el grado de satisfacción personal de estas personas en relación con el uso de TIC, concretamente dispositivos electrónicos para acceder a redes sociales.

Se diseñó un estudio de casos intrínseco, donde se seleccionó una muestra de personas mayores de 60 años, de la zona de Málaga capital. las estrategias de recogida de información fueron grupo focal, observación y cuestionario no estandarizado.

Fueron obtenidos resultados significativos sobre cómo y en qué medida el uso de estos recursos tecnológicos, aumentan la satisfacción personal del colectivo estudiado, desde la perspectiva de los protagonistas.

Como conclusión, las personas participantes mayores de 60 años, perciben, en su mayoría, una alta satisfacción personal, que crece en la medida en que se adaptan al uso de recursos tecnológicos para su vivencia en redes sociales, concretamente el whatsapp y el facebook, que les permite una mayor conexión con el mundo y con sus redes de apoyo social, como familia y amistades, a pesar de las limitaciones físicas o espaciales.
First-time and repeat visitors to Sarajevo
Authors: Čaušević Amra , Mirić Ranko , Drešković Nusret , Hrelja Edin
Published: July 2020

The aim of this research is to segment foreign tourists to Sarajevo based on the frequency of visits in order to make a distinction between first-time and repeat foreign tourists. The purpose is to discover if repeat foreign tourists have more positive intention to revisit and recommend Sarajevo, if they have more positive attitude towards overall satisfaction with tourist destination and if they have more positive opinion about the general quality of this tourist destination offer than first-time foreign tourists. The study used a quantitative approach for research. The survey sample is a convenience sample of 250 foreign tourists who visited Sarajevo during the winter (from December 10, 2018 to January 31, 2019). To achieve scientific relevance, during the analysis and interpretation of the obtained data, descriptive statistics and Mann–Whitney U test were used. The results showed that there was no statistically significant difference, and that first-time and repeat foreign tourists had the same intention of recommending Sarajevo, had a positive attitude towards the overall satisfaction of the tourist destination and had the same opinion about the general quality of this tourist destination offer. The results also indicated that repeat foreign tourists had more positive intention to revisit Sarajevo.
The Influence of Culture in Customers’ Expectations about the Hotel Service in Latin Countries with Different Human Development Levels
Authors: Franco Mara , Meneses Raquel
Published: July 2020

Due to their dynamic nature and importance in the service process definition, customers’ expectations have gained attention from researchers and practitioners, and have been essentially focused in developed countries from the Northern Hemisphere. Still, countries, regardless of the hemisphere, have different levels of socioeconomic development and cultural patterns that can have different influence on customers’ expectations about a service. In this sense, the main purpose of this research is to understand if culture equally influences customers’ expectations about a service in countries with different cultural patterns and human development levels. The multigroup analysis using structural equation modelling was used to calculate the regression weights for all the path combinations in the analysis for each proposed group of countries. About 1262 customers from 10 Latin countries were enrolled in this study to determine their expectations about the hotel service and cultural dimensions. Findings show that cultural dimensions influence customers’ expectations about the hotel service differently in groups of countries with different cultural patterns and levels of human development. Results also indicate that hotel managers should adapt the service to the level of human development of each group of countries when it comes to internationalisation.
Unveiling Madeira’s destination image and representations through Virtual Museum of Tourism (MUVITUR)®
Authors: Aurindo Maria José , Machado Conceição
Published: July 2020

This article intends to demonstrate the importance of the existence of an aggregating platform for digital content, as is the case of MUVITUR – Virtual Museum of Tourism, for the research in tourism and also to assess its potential.

Aiming to track the history of Madeira’s destination image, this paper also searches to contribute to the study of the ‘Atlantic Pearl’ distinctive features for promotional purposes throughout seventy years.

For this purpose, the authors did an integrated search aiming to find and study the retrieved results of promotional visual materials edited during the twentieth century, focusing on Madeira Island, as an example of the potentialities of the Muvitur database.

With this research, we can conclude that tourism marketing strategies seem to have succeeded to consolidate Madeira’s destination image focused on its distinctiveness. Digital objects gathered in such searchable thematic databases, with a diversity of content providers, can play a crucial role in the history of tourism and leisure, allowing us, at the same time, to know how Madeira represented the destination for promotional aims.
Factor Analysis of Prices and Agricultural Production in the European Union
Authors: Popović Goran , Erić Ognjen , Bjelić Jelena
Published: July 2020

Common agricultural policy (CAP) is a factor of development and cohesion of the European Union (EU) agriculture. The fundamentals of CAP were defined in the 1950s, when the Union was formed. Since then, CAP has been reforming and adapting to new circumstances. Treaty on the Functioning of the European Union defines the goals of CAP: stable (acceptable) prices of agricultural products, growth, productivity and technological progress in agriculture, growth in farmers’ income and supplying the common market. Factor analysis of the prices and production goals of CAP directly or indirectly involves the following variables: prices of agricultural and industrial products, indices of the prices of cereals, meat and milk, indices of the prices of agricultural products in France and Great Britain, agricultural GDP and EU GDP. The analysis results come down to 2 factors. The first – “internal factor” is a set of indicators homogenous in terms of greater impact of CAP on their trends (the prices of agricultural products in France, income from agriculture, the prices of agricultural products in EU and Great Britain and the milk price index). The second - “external factor” is made of general and global indicators (cereals prices, EU GDP and prices in industry). Factor analysis has confirmed high correlation of goals: production growth, productivity and technological progress in agriculture as well as “reasonable” prices in agriculture. The analysis shows high correlation between agricultural and industrial products, indices of the prices of cereals, meat and milk, indices of the prices of agricultural products in France and Great Britain, agriculture GDP and EU GDP (classified into internal and external factors). In general, the results of the factor analysis justify the existence of CAP, while the EU budget support brings wider social benefits.
Development of Receptive Factors on the Principles of Sustainable Tourism Development - Budva Case
Authors: Županović Ivo , Krivokapić Ana
Published: July 2020

Sustainable tourism implies establishing a positive relationship and link between tourism development and environmental protection, i.e achieving a full harmony between economic and environmental interests. Tourism that is based on respect for ecological interests can ensure the constant maintenance of balance in the natural environment and tourism development. Building a private accommodation association, as one of the aspects of sustainable tourism, ensures the long-term sustainability that is needed for the destination of Budva, due to the large number of problems it encounters, starting from the gray business zone to the very poor quality private accommodation, which is higher than in basic accommodation, which should be the basis of tourism development. In view of the given problem, the subject of research of this paper is the direction in which the receptive factors in the destination of Budva should be developed, with reference to the basic and complementary accommodation units.

The aim of the research is to provide a solution for the currently unfavorable receptive situation in the destination, with special focus on diffused and integral models of private accommodation.
Three-Dimensional Simulation of Flow Over Sharp-Crested Weirs Using Volume of Fluid Method
Authors: Rezazadeh Shiva , Manafpour Mohammad , Ebrahimnejadian Hamze
Published: July 2020

In sharp crested weirs, significant changes occur in the hydraulic characteristics of the flow past the weirs with different geometry. A detailed investigation and better understanding of hydraulic behavior will help practically to choose an appropriate geometry for weir. The purpose of this research is simulate the flow over sharp crested weir and investigate the effect of geometric shapes of sharp crested weirs on hydraulic characteristics of the flow such as pressure, velocity, water level profiles and discharge coefficients. Thus the limitation and usage range of sharp crested weirs are clarified. In this research OpenFOAM open source 3D software with RNG K-ε turbulence model and Volume of Fluid method (VOF) was used to analyze the hydraulic flow passing through sharp crested weir. The correlation coefficient for flow Surface profiles and discharge coefficients among numerical and experimental data is obtained 0.96 for different discharge rates. In the present research, discharge coefficients for rectangular weirs with compression coefficient 0%, trapezoidal and triangular weirs are determined 1.20, 0.68 and 0.51 respectively using discharge rate of 0.05183m3/s. The maximum discharge coefficient is obtained for rectangular sharp crested weir while the triangular sharp crested weir has minimum discharge coefficient.
Restructured class of estimators for population mean using an auxiliary variable under simple random sampling scheme
Authors: Baghel S. , Yadav S. K.
Published: July 2020

The present paper provides a remedy for improved estimation of population mean of a study variable, using the information related to an auxiliary variable in the situations under Simple Random Sampling Scheme. We suggest a new class of estimators of population mean and the Bias and MSE of the class are derived upto the first order of approximation. The least value of the MSE for the suggested class of estimators is also obtained for the optimum value of the characterizing scaler. The MSE has also been compared with the considered existing competing estimators both theoretically and empirically. The theoretical conditions for the increased efficiency of the proposed class, compared to the competing estimators, is verified using a natural population.
When cultural strength means political weakness: Romania’s marriage referendum and the paradox of conservative mobilisation
Authors: Racu Alexandru , Giugăl Aurelian , Johnston Ron , Gavriş Alexandru
Published: July 2020

Held on 6–7 October 2018, the Romanian referendum on the topic of gay marriage was the fourth referendum of this kind organised in East Central Europe over a five-year period. Because turnout was low in all of them and demands explanation, this paper: i) discusses the common characteristics of these Eastern European marriage referendums, contextualising the Romanian referendum; ii) overviews the history of the Romanian referendum, emphasising the legal, political, ideological and societal aspects; iii) quantitatively examines the electoral geography of the voting patterns; and iv) interprets qualitative data seeking to understand the voters’ choices and why conservative mobilisation was so weak.
Geographies of tacit knowledge transfer: Evidence from the European co-authorship network
Authors: Jeck Tomáš , Baláž Vladimír
Published: July 2020

The patterns of scientific cooperation between the 28 European Union (EU) member countries, Switzerland and Norway, from 1993 and 2017, are evaluated in this article. We consider co-authorship patterns to be proxies for international transfers of tacit knowledge. The theoretical part of the paper contains propositions by researchers in evolutionary economic geography on path-dependence, selection and variation, and the role of networks in knowledge transfer. The principal argument is that the geographical configurations of knowledge transfers over distance are shaped via a set of connectivities – specific communication channels for the exchange of people, goods and knowledge between two or more countries. Some connectivities are more conducive for the transfer of explicit knowledge (e.g. merchandise trade, trade in patents), while human exchange flows (students, migrants, travellers) favour the transfer of tacit knowledge. The research project found that a considerable increase in human exchanges has helped to increase the total number of co-authored papers, but did not amend the geography of the European co-authorship network over last two decades. Rather, the layout of the network stems from a relatively stable set of historical, cultural and political legacies in Europe.
Commuting pays off: Evidence on wage returns to inter-urban and intra-urban commuting
Authors: Vontroba Jakub , Balcar Jiří , Šimek Milan
Published: July 2020

The distance a person is willing to commute has a direct influence on her/his employment opportunities and wage level. It raises a lot of interesting questions, especially whether intra-urban commuting (due to a well-developed transport infrastructure, geographical concentration of job opportunities, etc.) is connected with any wage returns, and how they differ in comparison with those of inter-urban commuting. This article uses three data-sets at national (N1 = 1,884; N2 = 933) and local (N3 = 3,193) levels from the Czech Republic, and different approximations of commuting in order to contribute to the discussion. It provides robust evidence on positive wage returns to both inter-urban and intra-urban commuting, comparable with Western countries. The differences between large national and limited urban labour markets are reflected in functional form: wage returns are linear for intra-urban and non-linear for inter-urban commuting. The article also explores the validity of different measures of commuting time and distance provided by the on-line application Mapy.cz, and suggests that it represents a suitable approximation in the case of missing or limited data.
Evolution of Corvids and their Presence in the Neogene and the Quaternary in the Carpathian Basin
Authors: Kessler Jenő Eugen
Published: July 2020

Corvids are the largest songbirds in Europe. They are known in the avian fauna of Europe from the Miocene, the beginning of the Neogene, and are currently represented by 11 species. Due to their size, they occur more frequently among fossilized material than other types of songbirds, and thus have been examined to the largest extent. In the current article, we present their known evolution and their fossilized taxa in Europe and examine the osteology of extant species.
The Effects of Creatine and Related Compounds on Cardiovascular System: From Basic to Applied Studies
Authors: Draginic Nevena , Prokic Veljko , Andjic Marijana , Vranic Aleksandra , Pantovic Suzana
Published: July 2020

Beneficial effects of creatine were firstly shown in sport, where itself has been recognized as an ergogenic substance, increasing exercise endurancе, muscle strength and lean body mass. Creatine supplementation is very interesting, due to the fact that creatine supplementation have been reported to be beneficial for wide spectrum of diseases and conditions referring neuro-degenerative, rheumatic diseases, myopathies, cancer, type 2 diabetes. Creatine is a principle component of the creatine kinase/phosphagen system. In cardiomyocytes, it plays an important role in the buffering and transport of chemical energy to ensure that supply meets the dynamic demands of the heart. Studies in mice proved that elevated creatine protects the heart from ischemia-reperfusion injury. A natural precursor of creatine, guanidinoacetic acid (GAA), plays an important role as an energy carrier/mediator in the cell. GAA is formed in the first step of creatine synthesis. Supplementation with GAA might be of great significance in some circumstances where biosynthesis of GAA is limited like deficient diet, kidney failure, renal insufficiency, exercise-related GAA depletion. Betaine is a neutral compound in the form of zwitterion. Betaine supplementation is associated with improved cognition, neuroprotection, cardioprotection and exercise physiology. Betaine insufficiency represents increased risk for secondary heart failure and acute myocardial infarction. This mini-review outlines the evidence in support of creatine and creatine related compounds (GAA and betaine) elevation and examines the pharmacological approaches that are currently available. Since data from the available studies, regarding cardioprotection are inconsistent, this review might help clarifying the benefits of creatine, GAA and betaine supplementation on cardiovascular system.
Mechanical Properties of Welded Joints of 1.3964 Steel for Computer Aided Engineering (CAE) Purposes
Authors: Kiciński Radosław , Jurczak Wojciech
Published: July 2020

The article presents the study of mechanical properties of welded steel from which the hull of a modern mine destroyer was made. Keeping the tightness of ship compartments during operation depends on the strength of these joints. The results of testing the mechanical properties of 1.3964 steel and its welded joints subjected to a static tensile test were presented, and a Johnson – Cook material model was proposed. The material model can be used in CAE (Computer Aided Engineering) simulations related to hull strength analysis.
Accessibility and Usability of Landsat 8 Data for the Purpose of Satellite-Drived Bathymetry of the South Baltic Near-Shore Waters on the Example of Gulf of Gdańsk
Authors: Zwolak Karolina , Marchel Łukasz , Skóra Marcin , Przybysz Radosław , Jóźwiak Rafał , Tomaszewska Kinga
Published: July 2020

The paper presents the analysis of accessibility and usability of Landsat 8 Satellite Imagery for the purpose of Satellite Derived Bathymetry (SGB) products generation of the area of near-shore waters of the Polish coast. General assumptions of the SDB, Landsat program and factors affecting the products generation process have been described in details. Examples of SDB results, generated using both GIS software and Matlab, are presented on the example of chosen areas of Gulf of Gdańsk. The advantages and disadvantages of the SDB method are presented in the discussion and conclusion part with the proposed directions for the future works.
The Use of a Microcontrollers in Hygrometric Measurements Application
Authors: Bogdanowicz Artur , Zacharewicz Marcin , Król Jakub
Published: July 2020

The article presents the possibility of using microcontroller systems as one of elements of a teaching position. The Arduino Mega system based on the ATMega 2560 microcontroller from the AVR family was used to build the station. At the beginning, a virtual hygrometer model was designed in the AUTOCAD program and then the air channels were made using 3D printing. After assembling the station, it was compared to a laboratory aspiration hygrometer. The analysis was presented in the final part of the article.
Weather-Induced Moods and Stock-Return Autocorrelation
Authors: Khanthavit Anya
Published: July 2020

Moods affect investors’ attention, memory, and capacity to process information. Inattentive investors delay the price adjustment process, thus leading to a positive autocorrelation of asset returns. In this study, I investigate the relationship between weather-induced moods and stock-return autocorrelation in the Stock Exchange of Thailand from January 2, 1991, to December 29, 2017. Only good moods contribute significantly to return autocorrelation.
Factors Influencing Purchases of Organic Food
Authors: Jánská Michaela , Kollar Patrícia , Celer Čeněk
Published: July 2020

The goal of the article is to describe factors influencing purchases of organic food by consumers in a selected area of the Czech Republic. We have researched and analysed reference books and studies focused on the topic to fulfil the goals of the article. Data acquired during a questionnaire survey with selected consumers was used as primary data. The impact of different factors on the purchase of organic food was researched based on an effect of demographic indicators. Hypotheses were stated to study relations among variables, and we examined the statistical importance and correlation of particular hypotheses. We used another statistical method – a decision tree – to seek connections between the variables. The results show that purchases of organic food are influenced by the price, the taste, the sense of health and the content. The connection between the researched factors and demographic indicators is usually low and statistically insignificant.
PERFIL DO GESTOR DO SÉCULO XXI:
Authors: De Quadros da Silva Louise , Kerbes Aureo Da , Fossatti Paulo Da , Susana Jung Hildegard
Published: July 2020

Este estudo se refere ao perfil de gestores em escolas particulares de Educação Básica no século XXI. Com o objetivo de verificar as competências necessárias para o gestor de escola particular deste século, realizamos uma pesquisa bibliográfica a partir de artigos, dissertações, teses e livros. Como principal resultado apontamos para o gestor como profissional flexível e atento às mudanças sociais. Além disso, encontramos oito competências necessárias para um bom gestor do século XXI, a saber: a) Professor; b) Político; c) Inovador e empreendedor; d) Coordenador do trabalho pedagógico; e) Administrador material da escola; f) Planejamento estratégico; g) Liderança; e h) Personalidade segura, flexível e aberta ao diálogo. Concluímos que a principal característica necessária ao gestor de escola particular no século XXI que busca um trabalho inovador, consiste na flexibilidade para saber lidar com as diversidades que surgem em meio a sua jornada.
O O ESTADO DO CONHECIMENTO NA PERSPECTIVA DA PERMANÊNCIA DOS ALUNOS COM DEFICIÊNCIA NO ENSINO SUPERIOR
Authors: Kneipp Gabriella Marques
Published: July 2020

Este trabalho é resultante de uma pesquisa do estado do conhecimento, sendo uma proposta da disciplina de Enfoques da Pesquisa do curso de Especialização em Gestão Educacional da Universidade Federal de Santa Maria (UFSM). Teve por objetivo realizar uma análise de estudos já desenvolvidos sobre a temática da permanência dos alunos com deficiência no Ensino Superior. Portanto, procurou-se em períodos, dissertações e teses produzidos no período delimitado de 2015 até 2018 trabalhos que tenham o tema já referenciado. Por isso, acarretou-se em buscar pelos trabalhos detalhes que fossem acentuados destas bibliografias que pudessem futuramente contribuir para a escrita do trabalho final do curso de especialização em Gestão Educacional. Então, verificamos o valor de se pesquisar sobre os alunos com deficiência sua permanência neste espaço de ensino de grande valia. Os textos encontrados sinalizam que apesar da relevância do tema este ainda é pouco explorado e em sua maioria as obras são de cunho bibliográfico, estudos de caso e pesquisa documental.

 

Palavras-chave: Alunos com deficiência. Permanência. Ensino Superior.
Processos de Gestão da Qualidade em Empresa Familiar
Authors: Saldanha Bruno Da Silva , Brambilla Flávio Régio
Published: July 2020

O presente estudo surgiu com a finalidade de se verificar como se da o processo de gestão da Qualidade em uma empresa familiar, a empresa estudada é a Empresa Bertolo e Bianchini LTDA, mas conhecida popularmente como Madeireira Medianeira. A referida empresa oferece produtos do gênero de materiais de construção. A empresa surgiu com a visualização da oportunidade do negocio no mercado de Santa Maria, de seu José que já trabalhava a 15 anos no mercado de comercio de madeiras, com o aumento da demanda de seus filhos, identificou a necessidade de abrir um negocio para o futuro dos mesmos. Nos dias atuais a empresa já conta com instalações modernas, serviços qualificados, com um quadro de funcionários superior ao estimado e bem conceituada no mercado de materiais de construção. É uma empresa de médio porte formada por um consórcio entre irmão, onde eles se dividem em três setores: Financeiro, Compras e Estoques. As decisões são centralizadas, embora a empresa seja departamentalizada, o que facilita para a implementação de uma gestão da qualidade uma vez que a mesmo se baseia em processos, procedimentos e indicadores para cada setor.
Kadar Laktosa, Gula Reduksi, dan Nilai pH Yoghurt dengan Penambahan Bekatul Selama 15 Hari Penyimpanan Refrigerasi
Authors: Laksito Dyah , Wijaya Rizza , Nurfitriani Rizki Amalia
Published: July 2020

This study aimed to determine the effect of 15 days refrigeration storage on lactose content, reducing sugars, and the pH value of yoghurt by addition of rice bran. The experimental design used a completely randomized design (CRD) for 4 treatments and 5 replications. The treatments consisted of T0 (without storage), T1 (5 storage days), T2 (10 storage days), and T3 (15 storage days). The results showed that lactose content, reducing sugar, and pH value of yoghurt were analyzed by analysis of variance (ANOVA). If there were significant differences, then further tested by Duncan's Multiple Range Test. Yoghurt by addition of rice bran stored for 15 days in the refrigerator could reduce lactose content and pH values and increased the level of reducing sugar, so that be able to maintain the quality and freshness of yoghurt.
Meta-Analisis: Pengaruh Substitusi Jagung dengan Bahan Pakal Lokal Terhadap Kualitas Karkas Daging Broiler
Authors: Adli Danung Nur , Sjofjan Osfar
Published: July 2020

The purpose of this study was to determine the effect of substitution of corn with local ingredients on the quality of broiler meat using meta-analysis technique. This study used meta-analysis technique to integrate 55 data from 9 journals that contain information about replacing corn with local feedstuffs. The meta-analysis technique begins with collecting data from several scientific publications that contain tannin and saponin levels. Furthermore, the data was tabulated in the form of database with the help of microsoft excel, in this tabulation process the units of each data are equalized, after that the data was tabulated and analyzed using comprehensive meta-analysis version 3. The effect of corn replacement on the quality of broiler meat was not significant, this can be seen on the content of the percentage of carcasses, carcass weights, and cholesterol of meat was not different. The results show that the distance between the given model and the actual model indicates that there was decrease in the amount of cholesterol in meat with the replacement of corn in feed ingredients (0.05<P<0.1). The conclusion from the results of this meta-analysis was that the replacement of corn does not improve the quality of the broiler carcass.
THE EFFECTIVENESS OF USING COOPERATIVE LEARNING MODELS TOWARD PRE-SERVICE ELEMENTARY TEACHER�S UNDERSTANDING ON SOCIAL SCIENCE EDUCATION COURSE: A COMPARISON FOR COOPERATIVE SCRIPT, ARTICULATION, AND GUIDED NOTE TAKING
Authors: Hermawati Eli , Sari Mia Zultrianti , Fitriyani Yani
Published: July 2020

Our initial study in the course showed that there was a lack of students� understanding about social science. The purpose of this study was to investigated the effectiveness of using Cooperative Learning Model (Cooperative Script, Articulation, and Guided Note Taking) towards Pre-Service Elementary Teacher understanding on Social Science Course. This research was conducted in quasi-experimental research, with counterbalance research design. The subjects of this study were first year of undergraduate students of pre-service elementary school teacher education at the University of Kuningan. The data collection technique used was an instrument test which was an essay question. The data analyzed by statistical test with the t-test (independent samples t-test) at a 95% confidence level obtained tcalc > ttable and probability value sig. (2-tailed) < 0.05. The results of this study proved that there are differences in students' understanding so that the hypothesis is accepted. In our context, Cooperative Script was more sophisticated in improving student understanding compared to Articulation and Guided Note Taking. The limitation of our context means that there is no best method to be applied.Keywords: understanding; cooperative script; articulation; guided note taking; pre-service elementary teacher
PENERAPAN TEKNIK MENULIS INDUKTIF UNTUK MENINGKATKAN KETERAMPILAN MENULIS ESAI
Authors: Ukaliyah Ely
Published: July 2020

Proses pembelajaran menulis esai pada mata pelajaran Bahasa Sunda di Kelas VIII SMP Negeri 3 Kuningan masih ditemukan beberapa kendala, diantaranya kurangnya kreativitas siswa dalam menuangkan ide ke dalam tulisannya, masih rendahnya pemahaman siswa terhadap teknik menulis sebuah karangan dengan kohesi dan koherensi kalimat serta paragraf yang baik, kurangnya variasi metode yang diberikan guru pada proses pembelajaran, dan ketuntasan materi menulis esai baru mencapai 37,50% dari jumlah 32 siswa. Tujuan penelitian ini adalah untuk mengetahui hasil belajar Bahasa Sunda materi menulis esai siswa kelas VIII-E SMP Negeri 3 Kuningan setelah penerapan teknik menulis induktif. Penelitian Tindakan Kelas (PTK) ini menggunakan teknik menulis secara induktif dan proses perbaikan pembelajaran dengan menggunakan dua siklus. Sumber data penelitian ini adalah hasil evaluasi siswa dalam proses perbaikan pembelajaran dalam dua siklus. Respondennya adalah kelas VIII-E SMP Negeri 3 Kuningan yang berjumlah 32 siswa. Temuan dalam penelitian ini didasarkan pada perbandingan nilai hasil evaluasi siswa pada tiap-tiap siklus. Ketuntasan siswa dalam menulis esai dengan menggunakan teknik menulis induktif mengalami kenaikan yang signifikan setelah melakukan dua siklus perbaikan pembelajaran, yaitu menjadi 100% atau 32 orang siswa kelas VIII-E yang telah tuntas dalam pembelajaran.Kata Kunci: teknik menulis induktif; keterampilan menulis esai; Bahasa Sunda.
HEALTH-PRENEURSHIP: MENGAPA ILMU KESEHATAN MASYARAKAT MEMBUTUHKAN SEORANG ENTREPRENEUR?
Authors: Visnu Jodi
Published: July 2020

Pendahuluan: Dunia bisnis dalam beberapa tahun terakhir banyak diminati oleh generasi muda dari berbagai latar belakang pendidikan. Dunia medis pun harus berhadapan dengan persaingan bisnis dalam penyediaan layanan kesehatan. Pada hakikatnya, mahasiswa kedokteran mendapatkan pembelajaran tentang bisnis dalam kurikulum Ilmu Kesehatan Masyarakat lewat materi teori manajemen. Hal tersebut tidak dapat sepenuhnya terlaksana karena keterbatasan kurikulum pembelajaran. Bisnis dalam dunia kesehatan selayaknya linear dengan pelayanan kesehatan holistik dan berkualitas, komunikasi dokter-pasien yang efektif, sehingga perjalanan proses terapeutik berlangsung efektif dan terhindar dari berbagai hal negatif seperti ketidakpuasan pasien yang berujung pada tuntutan medis.Tujuan: Artikel ini digunakan sebagai bahan ajar perkuliahan health-entrepreneurship yang bertujuan untuk mengeksplorasi potensi entrepreneurship dalam bidang kesehatan, mengidentifikasi peran ilmu kesehatan masyarakat yang potensial dalam dunia bisnis untuk pembelajaran mahasiswa kedokteran dan merangsang adanya ide baru untuk berinovasi agar terwujud suatu kreativitas dan karya yang berkualitas.

Metode: Penulisan artikel ini menggunakan metode tinjauan naratif sebagai bagian dari studi literatur.

Diskusi: Materi entrepreneurship dalam bidang kedokteran tidak jauh dari ilmu kesehatan masyarakat. Mahasiswa belajar mengenai pemasaran, khususnya komunikasi dalam konteks promosi kesehatan yang berfokus kepada permintaan pasar dalam kurikulum entrepreneurship yang diajarkan. Seorang entrepreneur kesehatan diharapkan dapat menjaga kaidah pemasaran dalam etis kedokteran, dapat menjadi praktisi, problem solver, serta turut berkontribusi dalam bidang epidemiologi, kesehatan lingkungan, biostatistik, kebijakan kesehatan, manajemen pelayanan kesehatan, serta ilmu perilaku dan sosial.
Docking Studies of Usnic Acid and Sodium Usnate on SARS CoV-2 Main Protease and Spike Protein RBD
Authors: Guthappa Roopa
Published: July 2020

SARS CoV-2 a pandemic influenza like infectious disease emerged in December 2019 has spread throughout the world within few months. Scientists are trying their best to find medicine and vaccine. Usnic acid and its derivatives as herbal supplements are widely used as mouth wash, cosmetics, antiviral agents. In this study, usnic acid and its derivative-sodium usnate in comparison with favipiravir are docked with main protease and spike protein RBD 6M0J of SARS Cov-2. Usnic acid and sodium usnate exhibit better binding affinities for main protease and spike RBD. The data has been compared with favipiravir. Favipiravir, usnic acid, sodium usnate shows binding affinity of -4.25, -8.05 and -8.55 kcal/mol respectively with main protease. While favipiravir, usnic acid and sodium usnate exhibit binding affinities of -4.25, -6.02 and -6.53 kcal/mol with spike RBD respectively. One of the interesting features is that the inhibition constant values of usnic acid is 1.27 µM and sodium usnate is 539.86 nM in comparison to favipiravir (764.13 µM) with main protease.
QTAIM-Based Local Potential Energy Model: Applications and Limitations to Quantify the Binding Energy of Intra/intermolecular Interactions
Authors: FIRME CAIO
Published: July 2020

In previous work, we developed the local potential energy model, LPE, based on the electrostatic force and QTAIM topological data to quantify classical hydrogen bond energies. In this work, we extended the investigation to other inter/intramolecular interactions (non-conventional hydrogen bonds and others). The LPE presented high precision and linearity with supramolecular binding energy, when excluding interactions of an ion with π-bonded groups or polar molecule. The energy decomposition analysis from SAPT-DFT and LMOEDA showed that dispersion and electrostatic components are important to LPE, while polarization component impairs it. The LPE cannot be used for complexes with predominant polarization component.
Biomimetic Design of a Robustly Stabilized Folded State Enabling Seed-Initiated Helical Supramolecular Polymerization Under Microfluidic Mixing
Authors: Ogi Soichiro , Takamatsu Aiko , Matsumoto Kentaro , Yamaguchi Shigehiro
Published: July 2020

We have investigated the folding and assembly behavior of an alanine-based monomeric diamide and a cystine-based dimeric diamide bearing pyrene units and solubilizing alkyl chains at their C-termini andN-termini, respectively. In low-polarity solvents, the former molecule forms a folded 7-membered ring conformation with an intramolecular hydrogen bond, while the latter molecule forms a 14-membered ring through double intramolecular hydrogen bonds between two diamide units. Spectroscopic studies revealed that both folded states are thermodynamically unstable and eventually transform into more energetically stable supramolecular polymers. Importantly, compared to the alanine-based diamide, the cystine-based dimeric diamide exhibits a superior kinetic stability in the metastable folded state, as well asan increased thermodynamic stability in the aggregated state. Consequently, spontaneous transformation from the folded state into the aggregated state is retarded even under the conditions of rapid molecular diffusion. Accordingly, the initiation of supramolecular polymerization can be regulated via a seeding approach under microfluidic mixing conditions. Furthermore, the supramolecular polymer composed of the cystine-based dimeric diamide has a helical structure with an enhanced chiral excitonic coupling between the transition dipoles of the pyrene units. Taking advantage of the self-sorting behavior observed in a mixture of l-cysteine- and d-cysteine-based dimeric diamides, a two-step supramolecular polymerization from a racemic mixture was achieved by stepwise addition of the corresponding seeds.
Enantioselective Synthesis of Chiral Amines via Biocatalytic Carbene N—H Insertion
Authors: Steck Viktoria , Carminati Daniela Maria , Johnson Nathan R. , Fasan Rudi
Published: July 2020

Optically active amines represent highly valuable building blocks for the synthesis of advanced pharmaceutical intermediates, drug molecules, and biologically active natural products. Hemoproteins have recently emerged as promising biocatalysts for the formation of C—N bonds via carbene transfer, but asymmetric N—H carbene insertion reactions using these or other enzymes have so far been elusive. Here, we report the successful development of a biocatalytic strategy for the asymmetric N—H carbene insertion of aromatic amines with 2-diazopropanoate esters using engineered variants of myoglobin. High activity and stereoinduction in this reaction could be achieved by tuning the chiral environment around the heme cofactor in the metalloprotein in combination with catalyst-matching and tailoring of the diazo reagent. Using this approach, an efficient biocatalytic protocol for the synthesis of a broad range of substituted aryl amines with up to 82% ee was obtained. In addition, a stereocomplementary catalyst useful to access the mirrorimage form of the N—H insertion products was identified. This work paves the way to asymmetric amine synthesis via biocatalytic carbene transfer, and the present strategy based on the synergistic combination of protein and diazo reagent engineering is expected to prove useful in the context of these as well as other challenging asymmetric carbene transfer reactions.
Rapid High Resolution Visible Light 3D Printing
Authors: Ahn Dowon , Stevens Lynn , Zhou Kevin , Page Zachariah
Published: July 2020

Light-driven 3D printing to convert liquid resins into solid objects (i.e., photocuring) has traditionally been dominated by engineering disciplines, yielding the fastest build speeds and highest resolution of any additive manufacturing process. However, the reliance on high energy UV/violet light derived from decades of photolithography research, limits the materials scope due to degradation and attenuation (e.g., absorption and/or scattering). Chemical innovation to shift the spectrum into more mild and tunable visible wavelengths promises to improve compatibility and expand the repertoire of accessible objects, including those containing biological compounds and multi-material structures. Photochemistry at these longer wavelengths currently suffers from slow reaction times precluding its utility. Herein, novel panchromatic photopolymer resins were developed and applied for the first time to realize rapid high resolution visible light 3D printing. The combination of electron deficient iodonium and rich borate co-initiators were critical to overcoming the speed-limited photocuring with visible light. Furthermore, azo-dyes were identified as vital resin components to confine curing to irradiation zones, improving spatial resolution. A unique screening method was used to streamline optimization (e.g., exposure time and azo-dye loading) and correlate resin composition to resolution, cure rate, and mechanical performance. Ultimately, a versatile and general visible light-based printing method was shown to afford 1) stiff and soft objects with feature sizes < 100 μm, 2) build speeds up to 45 mm/h, and 3) mechanical isotropy, rivaling modern UV-based 3D printing technology and providing a foundation from which bio- and composite-printing can emerge.
Genetically Encoded Fragment-Based Discovery (GE-FBD) from Phage-Displayed Macrocyclic Libraries with Genetically-Encoded Unnatural Pharmacophores
Authors: EKANAYAKE ARUNIKA , Sobze Lena , Youk Jihea , Bennett Nicholas J. , Mukherjee Raja , Bhardwaj Atul , Wuest Frank , Derda Ratmir
Published: July 2020

Genetically encoded fragment-based discovery (GE-FBD) from phage-displayed macrocyclic libraries with genetically-encoded unnatural pharmacophoresLate stage functionalization of genetically encoded 1,3-diketone macrocyclic phage libraries by pharmacophores containing hydrazine handles.
On the Role of Enthalpic and Entropic Contributions on the Conformational Free Energy Landscape of MIL-101(Cr) Structural Building Units
Authors: Kollias Loukas , Cantu David , Glezakou Vassiliki-Alexandra , Rousseau Roger , Salvalaglio Matteo
Published: July 2020

The thermo-structural behavior of metal-organic framework (MOF) precursors is responsible for regulating the introduction of defects in MOF structures during synthesis. In this paper, factors affecting the flexibility of MIL-101(Cr) half-secondary building units (half-SBUs) are evaluated in solution using enhanced sampling methods. In particular, entropic and enthalpic contributions to the conformational free energy landscape of isolated MIL-101(Cr) half-SBUs are calculated in water, in the presence and absence of ionic species (Na+ and F-), and in N, N-dimethylformamide (DMF). This analysis leads to the observation that the interplay between enthalpy and entropy determines the most probable conformational state for half-SBUs. Furthermore, the role of enthalpy and entropy in the conformational rearrangement of an SBU is investigated in water, noting that entropic contributions are essential to stabilize configurations that depart from those coherent with the MIL-101(Cr) crystal structure. This analysis highlights the importance of explicitly considering entropic effects on the configurational ensembles of MOF building units and highlights the significant impact they have on the relative stability of crystal-like and non-crystal-like conformers.
Estimación del rendimiento del cultivo de Passiflora Edulis (Maracuyá) a partir de modelos estadísticos
Authors: Ramírez Castañeda Leila Nayibe , Potes Potes Santiago
Published: July 2020

La planificación de cultivos necesita herramientas de apoyo que faciliten la toma de decisión para determinar su sostenibilidad económica, social y ambiental. Este artículo presenta un análisis estadístico para los datos históricos entre 2007 y 2014 de las variables independientes agroclimáticas de la estación código 21055020, ubicada en las coordenadas latitud 2,378 y longitud -75,89, en el municipio de La Plata, departamento del Huila, Colombia. Como objetivo principal, se propuso estimar el pronóstico del rendimiento utilizando dos modelos matemáticos: ARIMA y Regresión Múltiple, recomendados en la literatura científica. Finalmente, se comparan los resultados para comprender el sistema de producción del cultivo y establecer las interacciones del rendimiento con las variables agroclimáticas. Se tomó como referencia para este estudio el cultivo de maracuyá (Passiflora Edulis), debido a su importante impacto económico y social para los productores de la zona. Se concluyó que el modelo de regresión múltiple subestima los picos de mayor rendimiento; además, el ajuste del modelo es muy bajo, lo que implica que este modelo es descriptivo y no predictivo, mientras que el modelo ARIMA se recomienda por su mejor ajuste a las series de tiempo analizadas.
Nivel de conocimiento en maintenance resource management (MRM) en el CACOM-3 de la Fuerza Área Colombiana
Authors: Rincón Barrera Rafael Andrés
Published: July 2020

El propósito de esta investigación fue determinar el nivel de conocimiento en Maintenance Resource Management (MRM), que posee actualmente el personal técnico que labora en mantenimiento de aeronaves A-37B, A-29, C-95, SR-560, C-208 y B 212 en la Fuerza Aérea Colombiana (FAC) en el Comando Aéreo de Combate No. 3 (CACOM-3), en busca de mejorar cada día más la Seguridad Operacional al interior de la Fuerza.

El procedimiento establecido para determinar el nivel de conocimiento en (MRM), consistió en diseñar un instrumento de recolección de datos en Safety Management System (SMS), Human Factors (HF) y Normatividad FAC vigente (Manual de Mantenimiento y Mensajes Técnicos [1]), como aspectos fundamentales para un entorno operacional administrado bajo la cultura de un sistema integrado de MRM en la FAC. Con esta información se estableció estadísticamente cuales son los aspectos del conocimiento más débiles en el personal de Oficiales de Mantenimiento, Inspectores, Jefes de Grupo y Operarios que labora en el proceso de mantenimiento aeronáutico bajo los mismos parámetros. Finalmente, se presentan los resultados del análisis de la información obtenida y se concluye con el nivel de conocimiento en Seguridad Operacional y Manejo de Recursos de Mantenimiento en el Comando Aéreo de Combate No. 3.