bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification and evaluation of drug related problems to first line therapy of antitubercular drugs among the pulmonary tuberculosis patients in a tertiary care hospital- A Randomised controlled study
Authors: Yeswanth Raja Bandaru , Ganachari Madiwalayya Shivakantayya
Published: July 2024

The standard treatment involves the use of first line antitubercular therapy for treating pulmonary tuberculosis (TB) in treating pulmonary tuberculosis (TB). This treatment is associated with many drug-related problems (DRPs) and adverse drug reactions (ADRs). A single blind randomized, controlled study was conducted on 250 patients to identify and evaluate the DRPs and ADRs among the newly diagnosed pulmonary TB patients in a tertiary care hospital. The patients were classified as the usual care group (Control) and pharmaceutical care intervention group (Test). At the end of follow up of the study, the DRPs were assessed by using PCNE classification V9.1. The causality assessment of ADRs was done with Naranjo algorithm, severity assessment was carried with modified Hartwig and Siegel scale and the preventability of ADRs was assessed with modified Schumock and Thornton scale. The statistical percentage analysis was done using with Microsoft Excel 2019. Of 250 participants, 88% had DRPs and developed one or more ADRs. The DRPs of Adverse drug event (possibly) occurring, unclear problem/complaint, duration of treatment too long, medication reconciliation problem and inappropriate timing or dosing intervals were found to be more. The severity of ADRs around 94.55% were mild and 5.45% were moderate. The causality of ADRs around 94.09% were possible and 5.92% were probable, while the preventability of ADRs found around 89.55% definitely preventable and 10.45% were probably preventable. The study concludes the importance of clinical pharmacists in pharmaceutical patient care will contribute in understanding different DRPs and ADRs in the management of TB.
Assessing the Effect of Portulaca oleracea Seed Extract for Alleviating Collagen Type-II Induced Arthritis in Female Wistar Rat
Authors: Gupta Harishankar , Rajashekhar U , Jha Deepak Kumar
Published: July 2024

Rheumatoid arthritis is a sign of progressive degradation of cartilage, subchondral bone, and small joints, as well as the persistence of synovitis and the formation of pannus. This research intends to assess the purported anti-arthritic effects of an extract from the seeds of Portulaca oleracea. Female Wistar albino rats (140–200 g) were used and assigned to five groups: Group I administrated NS (10 ml/kg), Group II received 0.2 ml of CoII-IFA, Group III received 300 mg/kg of fish oil, and Groups IV & V administrated 100 and 200 mg/kg of methanolic extract of Portulaca oleracea (MePO). During the experiment, the rats' weight, arthritic score, and footpad oedema were evaluated to determine the severity of their arthritis. Later, blood samples were collected from the animals, which were then analysed for haematological, pro-inflammatory, antioxidant, and histological parameters. A dose-dependent reduction was seen in rats treated with a methanolic extract of Portulaca seeds. Levels of haematological and pro-inflammatory cytokines were considerably reduced by treatment. Although both the standard drug and 200 mg/kg of MePO had anti-inflammatory effects, the latter's were more pronounced at this dose. When looking at the two side by side, results showed that the treatment groups of RBC, WBC, NL-ratio, and ML-ratio levels were normalised. Further histology confirmed the reduction of joint deformity, oedema, formation of pannus, and infiltration of neutrophils in the MePO groups in contrast to arthritic rats. It is hypothesised that Portulaca oleracea may reduce the arthritis and can be used as an adjuvant therapy or incorporate it into your diet with the main course of treatment.
Formulation Development and Evaluation of Biodegradable Stent of Atorvastatin and Clopidogrel for Treatment of Atherosclerosis
Authors: KANABAR VISHVESH , Patel Vipul
Published: July 2024

This study aimed to create, develop, and optimize a biodegradable stent made of poly lactic co glycolic acid (PLGA) that contained clopidogrel and atorvastatin for the management of asthma. Solvent casting was used to create biodegradable stents. In particular, PLGA 75:25 polymer films were used to create stents using the solution-casting method. The base material was created by dissolving the polymer in isopropyl alcohol and adding PEG 400 as a plasticizer. As the active pharmaceutical ingredients in the stents, clopidogrel and atorvastatin were used. To avoid air bubbles, the resulting mixture was homogenized before being poured onto metal pans and allowed to gently evaporate in a refrigerator. The polymer films were then cut into strips, wound around cylindrical rods to form helical stents, and baked in an oven to guarantee that all of the isopropyl alcohol had evaporated. The biodegradable polylactic acid stents that included clopidogrel and atorvastatin demonstrated an impressive 99.34±0.44% encapsulation efficiency. Differential scanning calorimetry (DSC) analysis revealed that there were no chemical interactions between the stent's component parts. Significant water absorption over 80% was seen over a period of 8 days, which is remarkable. A thorough effect on disrupting plaque was seen at day 21, and on day 22, the stent began to biodegrade. Over the course of 20 days, the cumulative medication release percentage rose to 99.92%. According to the study's findings, treating atherosclerosis with an optimized biodegradable polymeric stent made of PLGA and combining atorvastatin and clopidogrel is a novel and promising treatment option.
Applications and Principles of Quality by Design (QbD) in European Union Regulatory Dossiers for Medicinal Products from 2020 to 2023
Authors: YAPARLA SRIHITH ROY , Yetukuri Koushik
Published: July 2024

Quality by Design, Dr. Joseph M. Juran first introduced this concept in the 1970s., represents a risk-based approach to drug development, emphasizing continuous risk management throughout a product's lifecycle and predefined objectives. Implementation guidelines are detailed in the International Council of Harmonization (ICH) standards Q8–11. About a decade ago, the European Medicines Agency (EMA) adopted QbD principles for the pharmaceutical regulatory framework in the European Union. Despite recognition as essential in 2014, the integration of QbD into European marketing authorization applications remains limited and is not standardized. Using information from EPARs, a recent four-year study (2020–2023) aimed to evaluate how QbD principles were applied in all EU-approved marketing applications. Approximately 33.13% (111) out of 335 pharmaceuticals were developed using quality by design (QbD) principles, and 37.01% of all permitted drugs (77 out of 208 under article 8(3)) used QbD. Remarkably, over the course of four years, 30–40% of approved items that were presented as stand-alone documents adopted QbD. Most approved fixed-dose combination medications (71% in 2020 and 100% from 2021 to 2023) were, interestingly, developed utilizing a QbD strategy. Furthermore, four applications for market authorization incorporating QbD principles in the dossier were denied by the EMA. In conclusion, according to EPARs, regulatory dossiers lack complete QbD implementation, but the modest use of QbD components suggests a growing interest among businesses, potentially indicating a shift towards accepted development standards. Effective communication between regulatory bodies and companies is crucial for addressing challenges in QbD application.
Propiedad Intelectual de los Conocimientos Tradicionales de los Pueblos Ancestrales en la Industria de la Moda
Authors: Contreras Bohorquez Paula Andrea
Published: July 2024

La industria de la moda, ha sido catalogada en los últimos años como una de las que ha tenido mayor crecimiento en el mercado; sin embargo, surge en esta industria la particular necesidad de abordar factores propios de la propiedad intelectual debido a las implicaciones al momento de generar una marca, diseño o sello personal para innovar y generar un valor agregado a los productos que se pretenden lanzar al mercado y de las cuales, como cualquier otra creación del intelecto humano, requieren protección.
Bajo este panorama, los pueblos ancestrales han generado creaciones, basados en su cultura, cosmovisión y la manera como ellos perciben el arte en el diseño y en la manera de vestir, usando diferentes técnicas y materiales que les ha dado un reconocimiento dentro esta industria, debido a su originalidad e identificación personal, lo cual a su vez genera la necesidad de hacer un examen de cómo se protege estas creaciones en el ordenamiento jurídico Colombiano.
Con lo anterior, el presente artículo busca explicar las implicaciones de los conocimientos tradicionales y la industria de la moda, a la luz de las normas propias de la propiedad intelectual, con el fin de demostrar los diversos procesos que se han derivado de esta dinámica y que pueden ser traducidos en el concepto de apropiación cultural.
STRATEGI KOMUNIKASI PEMBELAJARAN PENDIDIKAN AGAMA HINDU DAN BUDI PEKERTI DI SEKOLAH DASAR SATHYA SAI DENPASAR
Authors: I Nengah Dana Wijaya  , I Gede Januariawan  , Ni Wayan Sariani Binawati
Published: July 2024

Penelitian ini membahas strategi pembelajaran komunikasi yang dipegang oleh guru agama dan karakter Hindu di SDN Sathya Sai Denpasar. Strategi Komunikasi pembelajaran perlu diteliti karena memainkan peran yang sangat penting dalam proses pembelajaran. Pelajaran agama dan karakter Hindu sebagai bagian dari studi ini adalah dianggap penting karena agama Hindu adalah sebagai dasar karakter dan Karakter adalah aspek penting dari pendidikan. SD Sathya Sai Denpasar adalah Sekolah yang menerapkan nilai-nilai kemanusiaan dalam proses pembelajaran. Nilai-nilai kemanusiaan sangat tinggi dianggap sebagai inti dari karakter manusia. Karakter siswa perlu dikembangkan melalui strategi komunikasi pembelajaran yang tepat. Penulis ingin menemukan : 1) Bagaimana strategi pembelajaran komunikasi; 2) Bagaimana penerapan  pembelajaran media; dan 3) Kendala apa yang dihadapi guru; dalam kaitannya dengan agama Hindu dan pelajaran karakter. Tiga pertanyaan penelitian dianalisis oleh humanistik dan teori belajar perilaku. 
Penelitian ini merupakan penelitian deskriptif kualitatif dengan pendekatan fenomenologis. Dia menggunakan metode purposive sampling. Informan utama adalah guru Hindu Pelajaran agama dan karakter serta informan pendukungnya adalah kepala sekolah dan beberapa siswa. Data dikumpulkan dengan instrumen, seperti: peneliti langsung observasi, wawancara dan studi dokumen Data yang diperoleh dianalisis dengan menggunakan model analisis Miles dan Huberman. Temuan penelitian menunjukkan bahwa: 1) strategi pembelajaran komunikasi yang dipegang oleh guru agama dan karakter Hindu di SD Sathya Sai Denpasar adalah metode humanistik dan perilaku. Si guru menggunakan berbagai model komunikasi dan berperilaku sebagai motivator dan fasilitator dalam proses pembelajaran. Guru menekankan komunikasinya pada menyapa, berdoa, duduk diam dan penegasan diri siswa untuk memulai pelajaran. Sambil menutup pelajaran dia mendorong siswa untuk bersyukur kepada Tuhan, guru dan satu sama lain karena pengetahuan telah dipelajari. 2) Guru memanfaatkan beberapa jenis pembelajaran media, seperti: buku teks sekolah, buku-buku agama Hindu lainnya, seperti Bhagavadgita, Karakter berisi buku cerita dan media audio visual. Selain itu guru juga Memanfaatkan fitur internet dan media sosial, seperti: Facebook, YouTube dan Grup WhatsApp. 3) Beberapa kendala terkadang masih terjadi selama proses pembelajaran. 
Kata kunci: Strategi komunikasi pembelajaran, Pendidikan agama Hindu dan budi pekerti, Sekolah Dasar Sathya Sai Denpasar
THE POSITIVE IMPACT OF HUDOQ CULTURE ON STUDENTS' CREATIVE CHARACTER FROM ONE OF THE CHARACTER PROFILES OF PANCASILA STUDENTS
Authors: Rosalia Amanda Utami  , Yohana Larasati  , Eny Winarti
Published: July 2024

Indonesia mempunyai banyak sekali keanekaragaman budaya, salah satunya adalah keanekaragaman tarian tradisional. Salah satu tarian tradisionalnya adalah tari Hudoq dari provinsi Kalimantan Timur yang biasa ditampilkan untuk memperingati upacara adat pada masa pembukaan lahan untuk cocok ditanam. Profil Siswa Pancasila merupakan pelatihan karakter sesuai nilai-nilai Pancasila dalam Kurikulum Merdeka yang memiliki enam indikator yaitu akhlak mulia, keberagaman global, gotong royong, penalaran kritis, kemandirian, dan kreativitas. Tujuan dari penelitian ini adalah untuk mendeskripsikan dampak positif budaya Hudoq terhadap karakter dalam Profil Siswa Pancasila khususnya karakter kreatif pada diri siswa. Jenis penelitian ini adalah penelitian deskriptif kualitatif dengan subjek yang telah ditentukan oleh peneliti yaitu anak-anak di desa Long Melaham, Mahakam Ulu, provinsi Kalimantan Timur. Hasil dari penelitian ini adalah melalui budaya Hudoq siswa menjadi lebih kreatif, hal ini sesuai dengan salah satu karakter pada Profil Siswa Pancasila, hasil tersebut terlihat ketika siswa membuat pakaian dan atribut yang digunakan untuk menari dan mengenang drama dalam suatu suasana berburu di depan masyarakat.
URGENSI AKSELARASI PENJAMINAN MUTU PERGURUAN TINGGI KEDINASAN MELALUI PELAKSANAAN AKREDITASI
Authors: Subiyakto Aang
Published: July 2024

The fact is that issues related to change, complexity and uncertainty have had a significant impact on the world of higher education, including official college. This implies the importance of the ability to survive, adapt and compete from the college in line with the dynamics of current developments. Regardless of the various problems, it has been proven that the official colleges are a national asset that has an important and strategic role in the development of human resources in Indonesia. The purpose of this descriptive paper was to explain the urgency of implementing PTK quality assurance through accreditation. Descriptive analysis was carried out based on studies and related laws and regulations. This paper showed that accreditation is important because it is related to aspects of quality assurance, legitimacy and credibility, international recognition, access to public and private funds, transfer and acceptance opportunities, and improving quality and accountability. The use of reference materials, techniques and depth of descriptive analysis may certainly be different from other similar studies. However, this paper may be one of reference materials for stakeholders, especially in addressing the need to accelerate the quality assurance efforts of official college through accreditation.
TRANSFORMASI PEMBELAJARAN BERBASIS MASALAH: USULAN MODEL PBL BARU UNTUK MENINGKATKAN KETERAMPILAN DAN KETERLIBATAN MAHASISWA
Authors: Setiawan Irwan , Hutahaean Jonner , Lian Min Joe , Chandra Nugraha Ade , Wisnuadhi Bambang
Published: July 2024

Penelitian ini bertujuan untuk membandingkan efektivitas model Pembelajaran Berbasis Masalah (PBL) konvensional dengan model PBL yang baru di antara mahasiswa tahun kedua Program Diploma III Teknik Informatika di POLBAN. Model PBL konvensional mengikuti pendekatan linear, sementara model baru membagi proses pembelajaran menjadi dua tahap yang berbeda dan menekankan pembentukan kelompok setelah fase awal. Analisis data dilakukan terhadap keterampilan pemecahan masalah, persepsi, dan keterlibatan mahasiswa terhadap PBL. Hasil penelitian menunjukkan bahwa model PBL baru secara signifikan lebih unggul dibandingkan model konvensional. Secara khusus, kehadiran free rider dalam model baru sangat sedikit, dan beberapa mahasiswa yang awalnya dikategorikan sebagai kategori rendah menunjukkan peningkatan dalam kinerjanya, bergeser menjadi kategori sedang. Beberapa mahasiswa dari kategori sedang juga bergeser menjadi kategori baik. Temuan ini menggarisbawahi pentingnya partisipasi aktif dan pengembangan individu dalam meningkatkan hasil pendidikan
THE IMPACT OF TOOTH-CUTTING CEREMONY ON HIV SUFFERERS IN KLUNGKUNG REGENCY
Authors: Wayan Jaya Putra  , I Nyoman Adiputra  , I Made Sugata
Published: July 2024

The tooth-cutting  ceremony is one of the manusa yadnya ceremonies that must be lived in the life of Hindus to control the six enemies in humans ( sad ripu). This study wanted to know the impact of the tooth- cutting  ceremony for the Balinese Hindu community in Klungkung Regency on HIV sufferers. The purpose of this study is to know. (1) The truth of the tooth-filing teaching in Hindu theology, 2) How the impact of the tooth- cutting  ceremony in Klungkung Regency on HIV sufferers, in this study is the relationship between culture and theoretical input in the concept of carrying out tooth- cutting  ceremonies in Klungkung Regency for HIV sufferers. This research is by qualitative method and data obtained by making observations including reading literature literature. Data is obtained through several stages: (1) observation of the object of research, so that documents in the form of photos / videos about the implementation of the tooth- cutting  ceremony are obtained. (2) interviews were conducted with HIV sufferers and families who performed the tooth- cutting  ceremony. Prejudice and public treatment of HIV sufferers is very positive where Hindu culture builds the self-confidence of HIV sufferers kikir.
RELIGIOUS PLURALITY AT PUJA MANDALA NUSA DUA BALI BUALU TRADITIONAL VILLAGE, BENOA URBAN VILLAGE, SOUTH KUTA DISTRICT
Authors: Mancapara I Gede Pasek , I Nengah Duija  , Ni Ketut Srie Kusuma Wardhani
Published: July 2024

This research examines the religious plurality that occurs at Puja Mandala Nusa Dua Bali with a problem formulation; (1) Why does the practice of religious plurality emerge in Puja Mandala Nusa Dua Bali, (2) What is the process of religious plurality in Puja Mandala Nusa Dua Bali, (3) What are the implications of religious plurality in Puja Mandala Nusa Dua Bali.
The theories used are Weber's social action theory, Bourdieu's social practice theory, Blau's exchange theory, and Parson's structural functionalism theory. This type of qualitative research uses a phenomenological approach. The research results show that the emergence of religious plurality in Puja Mandala is due to; (1) Historical Factors of Religious Harmony in Bali, (2) Factors of creative actors, (3) Motive and Goal Factor, (4) Imaginary Idea of Harmony Factor. The practice of religious plurality that occurs at Puja Mandala includes; (1) there is online or interpersonal social interaction, 2) there is PAUB/ Inter-Religious Association, (3) there is intrinsic and extrinsic social exchange (4) there are values used in individual and group activities. The implications of religious plurality in Puja Mandala Nusa Dua Bali are in the form of; (1) adaptation, (2) integration, (3) achieving goals, (4) maintaining unity motivation. The findings in this research are the existence of superstructure, infrastructure and structures, which because the realization of religious plurality at Puja Mandala
YOGA AND CROSS-CULTURAL COMMUNICATION IN MULTICULTURAL ENVIRONMENTS
Authors: Ni Luh Sinar Ayu Ratnadewi  , I Nyoman Sueca
Published: July 2024

The journal focused on investigating the transformative role of yoga within diverse cultural contexts. In an era characterized by unprecedented multiculturalism and global interaction, yoga emerges as a powerful cultural bridge, enhancing cross-cultural understanding and fostering inclusion. This journal invites rigorous academic exploration of yoga's multifaceted influence. It welcomes research spanning historical roots, cultural adaptations, and psychological dynamics of yoga practice within multicultural societies. Interdisciplinary dialogue is encouraged, with a focus on psychology, communication, anthropology, sociology, and cultural studies, providing a comprehensive view of yoga's cross-cultural impact. Ethical considerations related to the practice and propagation of yoga are explored, alongside practical applications in promoting unity, well-being, and psychological resilience within diverse communities. The journal also engages with future directions in yoga research and application. Committed to academic rigor, "Yoga as a Cultural Bridge" aims to be a scholarly repository for in-depth inquiry into yoga's pivotal role in bridging cultural divides and fostering inclusive, harmonious societies. It promotes appreciation for cultural diversity and the shared human experience while advancing understanding of yoga as a cultural bridge.
O papel da psiquiatria em áreas afetadas por tragédias naturais
Authors: Weber César Augusto Trinta , Da Silva Antônio Geraldo
Published: July 2024

O estado do Rio Grande do Sul (RS), Brasil, desde o final de abril de 2024,  enfrenta a maior tragédia climática de sua história. Levantamento inicial do gabinete de crise do governo do RS aponta que as chuvas causarão danos que podem totalizar R$ 19 bilhões nas regiões atingidas. As fortes chuvas afetaram 450 municípios e a estimativa é que o número de desalojados já supera meio milhão de pessoas, com cerca de 80 mil pessoas em abrigos. Os danos diretos causados por inundações e deslizamentos atingem 2,1 milhões de pessoas. Eventos traumáticos de grande magnitude frequentemente impactam a saúde mental e desencadeiam respostas psicológicas negativas tanto nas vítimas diretas quanto nas comunidades afetadas, bem como nos profissionais envolvidos em operações de resgate, suporte logístico e assistência humanitária. Esses efeitos incluem um aumento significativo na incidência de TEPT, ansiedade e depressão. Nesse contexto, a Psiquiatria emerge como uma disciplina médica dedicada ao cuidado da saúde mental em sua totalidade, para oferecer a sua expertise no suporte emocional imediato, estabilização psicológica e triagem de riscos, intervenções terapêuticas e estratégias de prevenção a longo prazo para aliviar o sofrimento e promover a recuperação das vítimas.
Perceived Social Support on Depression, Anxiety and Stress During Pregnancy
Authors: Mohammed Ajmal R S  , Anjana Joshi P  , Arafa K A
Published: July 2024

The current study was conducted to understand effect of perceived social support on depression, anxiety and stress during pregnancy and whether there is any significant difference based on trimesters. The study sample consists of 107 pregnant women of age range 18 to 50 which was collected from different parts of Kerala. Google forms were used for the study and a questionnaire measure was used for the data collection. They responded to demographic variables, Depression Anxiety Stress Scale (DASS) and Multidimensional Scale of Perceived Social Support (MSPSS). The data analysis done by SPSS software version 23 using statistical indicators such as mean, standard deviation, Pearson correlation coefficient and ANOVA. Findings revealed that there is significant negative correlation between perceived social support, stress and depression. Also perceived family support and depression are negative correlated in pregnancy. In addition, there is a statistically significance difference in the mean value of depression between the different trimesters (first, second and third trimesters) we considered. Results clearly point out that psychological health of pregnant women is vulnerable and perceived social support positively affecting their mental health.
Konut Tedarik Zincirinde Kamçı Etkisinin Araştırılması
Authors: Tursun Abdurrahman
Published: July 2024

Hizmet ve üretim işletmelerinin karşılaştığı kamçı etkisi, tedarik zincirinde büyük dalgalanma ve kaos etkisi oluşturmaktadır. Konut tedarik zincirinde kamçı etkisinin ortaya çıkma olasılığının bilinmesi, barınma ve konut sorununun çözümü veya gerekli olan konut politikalarının geliştirilmesi açısından önemlidir. Çalışmada Türkiye’de konut tedarik zincirinde kamçı etkisinin ortaya çıkma durumunun tespit edilmesi amaçlanmıştır. Konut tedarik zincirinin yapısal özellikleri araştırılarak diğer çoğu tedarik zincirleri ile karşılaştırılmıştır. Konut tedarik zincirinin farklılaşan yapısal özelliklerinin kamçı etkisini ortaya çıkarmaya etkileri, yapılan karşılaştırmalı incelemeler sonucunda ortaya konulmuştur. Konut tedarik zincirinin, zincirdeki aktör sayısı, arz süresi ve ürün özellikleri gibi yapısal özelliklerinin diğer çoğu tedarik zincirlerinden farklı olduğu belirlenmiş ve bu özelliklerin konut tedarik zincirinde kamçı etkisinin ortaya çıkmasına olumsuz yönde katkı sağladığı sonucuna ulaşılmıştır. Konut piyasasında arz talep durumu ve konut tedarik zincirinin mevcut yapısı dikkate alındığında Türkiye’de konut tedarik zincirinde bir kamçı etkisinin beklenilmediği vurgulanmıştır.
Uso da gestrinona como recurso terapêutico no manejo clínico da endometriose
Authors: Paiva Maria Eduarda Almeida , Barroso Callina Haniel de Aguiar , Oliveira Heloísa dos Anjos , Brandão Isabela Soares , Monteiro Karina Azevedo de Carvalho , Roque Lara Emanuelle Santos , Costa Juliana Leles , Dobrachinski Leandro
Published: July 2024

Objetivo: Descrever o uso da gestrinona como recurso terapêutico no manejo clínico da endometriose. Métodos: Trata-se de uma revisão do tipo integrativa, cuja busca de dados foi realizada na Scientific Electronic Library Online (Scielo), National Library of Medicine (PubMed), and Latin American and Caribbean Health Sciences Literature (LILACS) databases, with a time frame between 1989 and 2022. Resultados: Dos 365 artigos encontrados, 15 foram selecionados a análise final. A gestrinona age no sistema endócrino, inibindo a produção de estrogênio e progesterona pelo ovário e, portanto, suprimindo o crescimento e a proliferação do tecido endometrial fora do útero. Além disso, a gestrinona tem efeitos anti-inflamatórios e imunomodulatórios, o que pode ajudar a reduzir a inflamação associada à endometriose. Embora a gestrinona seja eficaz no alívio dos sintomas da endometriose, ela também pode causar efeitos colaterais, como acne, aumento de peso, alterações no humor e na libido. Além disso, a gestrinona pode aumentar o risco de doenças cardiovasculares e outras condições de saúde. Considerações Finais: Pode-se considerar que a gestrinona é uma opção farmacológica eficaz para o tratamento da endometriose por atenuar a dor pélvica, principal sintoma da patologia.
The effect of a rehabilitation neck exercise program on biomechanical head alignment, neck pain, and disability among nursing students: A randomized controlled trial
Authors: Abd-Eltawab Amany E. , Shormana Mohamed A. A. , Elsherbini Dalia M. A. , ElRazkey Jehan Y.
Published: July 2024

Objectives:

The objectives of this study were to investigate the effect of a rehabilitation neck exercise program (RNEP) on head alignment, neck pain, and disability among nursing students.

Methods:

The present study involved 360 university nursing students, with 180 in an experimental group and 180 in a control group. The experimental group received an RNEP consisting of isometric, stretching, and range of motion (ROM) exercises for four weeks, while the control group was instructed to maintain their present level of physical exercise. The measurements obtained from the visual analog scale (VAS) for pain, neck disability index (NDI), and ruler measurements for the ROM were taken before and after treatment for both groups.

Results:

The present work showed a significant difference in the outcome variables for the ruler measurement, NDI and VAS (P < 0.001). Our results showed a significant improvement in ruler measurement and NDI in the experimental group (57.8% and 88.3%, respectively, compared to the control group (0.0%)). On the other hand, those measurements were significantly worse in the control group (28.3% and 63.1%, respectively). The number of participants with no pain was significantly increased in the experimental group (22.8%). The participants with mild pain were increased in the experimental group (40%) compared to baseline (36.1%) while decreased in the control group (35.6%).

Conclusion:

The controlled rehabilitation neck exercises program reduced the neck pain, disability index, and improved the ROM of upper cervical flexion. The occupational field of nursing requires regular exercises for the neck and cervical muscles.
Chromosome Xp22.3 deletion syndrome with X-linked ichthyosis, Kallmann syndrome, short stature, generalized epilepsy, hearing loss, attention deficit hyperactivity disorder, and intellectual disability – A rare report with review of literature
Authors: Gunasekaran Pradeep Kumar , Saini Lokesh , Rajial Tanuja , Manjunathan Sujatha , Laxmi Veena , Gupta Rahul , Kumar Ashna , Parameswaran Arun Sree , Palayullakandi Achanya , Budania Anil , Singh Kuldeep
Published: July 2024

Chromosome Xp22.3 deletion syndrome is a very rare contiguous gene deletion syndrome with variable phenotype due to the deletion of genes from the distal short arm of the X chromosome (Xp), including the short-stature homeobox (SHOX), anosmin-1 (ANOS1), arylsulfatase (ARSL), neuroligin-4 (NLGN4), and steroid sulfatase (STS) genes. We have reviewed the available literature on the chromosome Xp22.3 deletion syndrome. A 10-year-old boy presented with global developmental delay, generalized epilepsy, decreased hearing, and hyperactivity. He had no significant family history. Examination revealed microcephaly, short stature, and dry and scaly skin lesions on the trunk. He had thick arched eyebrows, a depressed nasal bridge, a long philtrum, high arched palate, retrognathia, brachytelephalangy, brachymetatarsia, and mild scoliosis. Brainstem-evoked response audiometry testing revealed moderate hearing loss. Magnetic resonance imaging showed cerebellar tonsillar ectopia. Clinical exome sequencing revealed a likely pathogenic contiguous deletion (~8.10 Mb) spanning genomic location chrX:g.(_630898)_(8732037_)del encompassing ANOS1, ARSL, NLGN4X, SHOX, and STS genes. We have reviewed the available literature for reported associations of Chromosome Xp22.3 deletion syndrome and report a novel association of X-linked ichthyosis, Kallmann syndrome, global developmental delay, short stature, bilateral hearing loss, generalized epilepsy, attention deficit hyperactivity disorder, and intellectual disability.
DEVELOPMENT OF THE METHOD OF CALCULATION OF BALANCING ESTIMATES BASED ON THE USE OF PERMANENT POLYNOMIALS
Authors: Меньших В.В. , Пьянков О.В.
Published: July 2024

Предлагается осуществлять исследование эргатических систем предметного назначения на основе применения теории конфликтов. Показаны внутренние показатели эффективности функционирования эргатических систем, представляющие собой оценки сбалансированности (конфликтности) элементов системы. Разрабатываются методы и алгоритмы, позволяющие осуществлять расчёт оценок сбалансированности конфликтных взаимодействий элементов эргатических систем. Обосновывается применение знакового графа G в качестве модели конфликтных взаимодействий элементов системы. Доказывается возможность применения перманентного многочлена матриц смежности P и Z графа G для расчёта оценок сбалансированности. Рассматривается метод Райзера, уменьшающий вычислительную сложность вычисления перманентного многочлена матриц смежности. Предлагается модификация метода Райзера, включающая вычисление суммы значений разрядов двоичного представления десятичных чисел, позволяющая осуществлять машинный расчёт, подробно приводятся примеры использования нового способа для вычисления перманента. На условном алгоритмическом языке показаны разработанные алгоритмы расчёта оценок сбалансированности.

It is proposed to carry out a study of objective object systems based on the theory of conflicts. Indicated internal indicators of the effectiveness of the functioning of ergatic systems, which are estimates of the balance of the elements of the system. Methods and algorithms are developed that allow the calculation of the balances of the conflict interactions of the elements of ergatic systems. The application of the sign graph G as a model of conflict interactions of the system elements is substantiated. We prove the possibility of applying the permanent polynomial of the adjacency matrices P and Z of graph G to calculate the balance estimates. We consider the Riser method, which reduces the computational complexity of calculating the permanent polynomial of adjacency matrices. We propose a modification of the Riser method, which includes calculating the sum of the digits of the binary representation of decimal numbers, allowing for computer calculations, and examples of using a new method for calculating the permanent are given in detail. On the algorithmic language, the developed algorithms for calculating the balance estimates are shown.
MODELS AND ALGORITHMS OF THE SOLUTION BASED ON VERBAL DATA ANALYSIS IN PRODUCTS ON PLATFORM 1C: ENTERPRISE
Authors: Кондрашов А.В. , Попова Н.А.
Published: July 2024

В настоящее время большинство задач решаемых в различных сферах деятельности имеют тенденцию к возрастанию сложности, при этом необходимо получить наилучшее решение в кратчайшие сроки. В связи с этим принятие решений становится нетривиальным процессом, а неверное решение влечет значительные убытки. Принятые решения влияют на развитие компании, организацию производственного процесса, определяют стратегию компании. Для задач по принятию решений служат программные средства - системы поддержки принятия решений. Системы поддержки принятия решений являются разновидностью форм искусственного интеллекта, которые помогают лицам, принимающим решения. Существует большое количество систем поддержки принятия решений, в основе которых используются математические и количественные методы. Вербальный анализ решений в отличие от них является одним из разделов в теории принятия решений, основанных на использовании нечисловой, качественной информации. Выявлено, что существует небольшое количество систем поддержки принятия решений, основанных на методах и алгоритмах вербального анализа. В данной работе производится обзор основных алгоритмов и методов вербального анализа решений, таких как: метод АРАМИС, метод АИР, а также основных методов многокритериального выбора и предоставляется модель, отражающая взаимодействие продуктов, основанных на платформе 1С: Предприятие, и реализующая перечисленные методы вербального анализа решений. Показанная модель комбинирует различные методы вербального анализа решений, многокритериальный отбор и процедуры согласования.

This article discusses the problem in taking responsible managerial decisions, which significantly affect the development of the company, the organization of the production process, the definition of the company's strategy. For the tasks of this plan are software - decision support systems. This is one of the varieties of forms of artificial intelligence, designed to help decision-makers. There are a large number of decision support systems based on quantitative data, at all stages of the analysis to solve the problem of decision making. Verbal analysis of solutions, in contrast to them, is one of the sections in the theory of decision-making based on the use of non-numerical, qualitative information. It was revealed that there is a small number of decision support systems based on methods and algorithms of verbal analysis. In this paper, we review the main algorithms and methods for verbal analysis of solutions, such as: the ARAMIS method, the AIP method, as well as the basic methods of multi-criteria choice, and provides a model reflecting the interaction of products based on the 1C: Enterprise platform and implementing the listed methods of verbal analysis of solutions. The model shown combines various methods of verbal analysis of solutions, multicriteria selection and coordination procedures .
ACCESS CONTROLS TO INFORMATION RESOURCES IN INFORMATION SYSTEMS
Authors: Лапина Т.И. , Димов Э.М. , Петрик Е.А. , Лапин Д.В.
Published: July 2024

В статье рассматривается поход к организации многофакторной аутентификации пользователей автоматизированных информационных систем. Показано, что при многопользовательском режиме доступа к информационному ресурсу через сетевые протоколы одной из основных задач обеспечения информационной безопасности ресурсов является подтверждение личности, вступающей в информационный обмен. В настоящее время при использовании единого информационного пространства автоматизированных информационных систем средства информационной безопасности должны обеспечивать еще поддержание детерминистической целостности. Под детерминистической целостностью информационных ресурсов подразумевается не только факт использования и взлома конфиденциальные данные предприятия, а способность средств защиты однозначно удостоверить целостность своих информационных ресурсов на основе минимизации риска проникновения посторонних пользователей. В статье рассмотрен подход организации доступа к информационным ресурсам автоматизированных информационных систем на основе многофакторной аутентификации. Проверка личности пользователя информационного ресурса выполняется после проведения стандартных процедур проверки факторов аутентификации и является одним из уровней многофакторной аутентификации. Для подтверждения личности пользователя предложено использовать методы динамической биометрической аутентификации на основе динамика рукописного почерка. Предложен комплекс технических средств получения биометрический данных пользователя, процедуры их анализа и алгоритм доступа к информационному ресурсу. Для формирования биометрического образа и эталона предложено использовать дискретное преобразование Фурье и систему ортогональных функций Хаара, позволяющих выделить существенные особенности измеряемых данных динамики рукописного почерка пользователя информационных ресурсов.

In article the campaign to the organization of multifactor authentication of users in automated information systems at remote access of many users to one information resource through network protocols is considered. It is shown that at a multiuser mode of data access of one of the main objectives of information security support of resources the problem of confirmation of the personality entering information exchange which can be solved by use of multiple-factor authentication is. For confirmation of the identity of the user dynamic biometric identification and authentications on a basis is used by dynes of hand-written handwriting. The complex of technical means of receiving biometric data, the procedure of their analysis and an algorithm of access to an information resource is offered. For forming of a biometric image, it is offered to use discrete transform of Fourier and the system of the orthogonal functions of Haar allowing to select essential features of the measured data of dynamics of hand-written handwriting of the user of information resources.
TECHNIQUE OF JUSTIFICATION OF ELECTRODYNAMIC AND CONSTRUCTIVE PARAMETERS OF CONSTRUCTIVE ABSORBING MATERIALS OF WAVEGUIDE TYPE
Authors: Ивенский А.А.
Published: July 2024

В работе предложена методика обоснования электродинамических и конструктивных параметров материалов волноводного типа, основанная на разработанной модели поглощения СВЧизлучения на импедансных стенках и диэлектрическом наполнителе конструкционных поглощающих материалов замкнутых волноводных структур. Сущность модели, основанной на методах теории дифракции электромагнитных волн в слоистых средах, законах распространения сверхвысокочастотного излучения в волноводах, заключается в том, что электромагнитное поле перед решеткой рассматривается в виде суперпозиции полей падающей плоской волны, зеркально отраженной от границы раздела среда материал, и рассеянной на стенках решетки материала. Электромагнитная волна, падающая на материал, по мере распространения вглубь него взаимодействует с радиопоглощающими стенками. Предложен подход определения коэффициента отражения материала, особенностью которого является то, что в выражение для расчета коэффициента отражения введено слагаемое, описывающее экспоненциальное снижение уровня амплитуды (плотности потока мощности) рассеянной составляющей электромагнитного поля при распространении ее вглубь материала и обратно от конструктивных и электродинамических параметров импедансных стенок и диэлектрического наполнителя замкнутых волноводных структур (закороченных волноводных отрезков), и позволяющий установить закономерности между отражательными характеристиками конструкционного поглощающего материала и его электродинамическими и конструктивными параметрами.

The paper proposes a method for substantiating the electrodynamic and structural parameters of waveguidetype materials, based on the developed model for the absorption of microwave radiation on impedance walls and the dielectric filler of structural absorbing materials of closed waveguide structures. The essence of the model, based on the methods of the theory of diffraction of electromagnetic waves in layered media, the laws of propagation of microwave radiation in waveguides, is that the electromagnetic field in front of the grating is considered as a superposition of the fields of the incident plane wave, mirrored from the mediummaterial interface, and scattered on the walls of the lattice material. An electromagnetic wave incident on the material, as it propagates deep into it, interacts with radioabsorbing walls. An approach is proposed for determining the reflection coefficient of a material, a feature of which is that a term is introduced in the expression for calculating the reflection coefficient describing an exponential decrease in the amplitude level (power flux density) of the diffuse component of the electromagnetic field when it propagates deep into the material and back impedance walls and dielectric filler of closed waveguide structures (shortcircuited waveguide segments), and allowing becoming patterns between reflection characteristics of the structural material and the absorbent electrodynamic and design parameters.
The fuzzy approach for clustering borrowers of microfinance organizations
Authors: Кузнецова В.Ю.
Published: July 2024

Развитие информационных технологий сопровождается комплексной трансформацией сферы услуг, в том числе и сферы микрокредитования. Ежегодно данная отрасль российского финансового рынка показывает стабильный рост. Однако на фоне высокой закредитованности населения России доступность микрокредитования для большинства граждан, в том числе в онлайн-режиме, привела к высокой доле дефолтных выдач микрозаймов в МФО. Давление регулятора и снижение доходов россиян привело большинство МФО к банкротству, а оставшихся игроков микрофинансового рынка принудило к снижению процентных ставок, и как следствие, существенно снизилась их маржинальность. В связи с этим у МФО возникает острая необходимость в разработке скоринговой модели, которая смогла бы выявлять еще на этапе заявки на микрозайм высокомаржинальных и «отсекать» потенциально дефолтных заемщиков. Действующая во многих финансовых структурах дуальная классификация не позволяет в полной мере отразить высокую прибыльность микрокредитования заемщиков с имеющейся просрочкой по сравнению с теми клиентами, кто возвращает заемные средства вовремя. В рамках данной работы предлагается методика кластеризации заемщиков на основе нечеткого критерия «уровень финансовой ответственности» и оценки эффективности микрофинансирования на основе расчёта рентабельности кредитного портфеля в зависимости от предложенной классификации заемщиков.

The development of information technology is accompanied by a comprehensive transformation of the service sector, including microcredit. This sector of the Russian financial market shows steady growth annually. However, amid the high debt load on the Russian population, the availability of microcredit for most citizens, including online, has led to a high share of default disbursements of microloans in MFIs. Pressure from the regulator and a decrease in the income of Russians led the majority of MFIs to bankruptcy, while the remaining players in the microfinance market led to lower interest rates, and as a result, their margins decreased significantly. In this regard, MFIs have an urgent need to develop a scoring model that would be able to identify high-margin borrowers at the stage of applying for a microloan and “cut off” potentially defaulted borrowers. As part of this work, a methodology is proposed for clustering borrowers based on the fuzzy criterion “level of financial responsibility” and assessing the effectiveness of microfinancing based on the profitability of the loan portfolio depending on the proposed classification of borrowers.
А classification approach based on a combination of deep neural networks for predicting failures of complex multi-object systems
Authors: Сай В.К. , Щербаков М.В.
Published: July 2024

Научно-технический прогресс способствовал бурному росту сложности систем и выполняемых ими функций, что особенно характерно для различных отраслей современной примышленности. Здесь цена отказа или сбоя оборудования может быть очень высокой а иногда и привести к неоценимым потерям, связанным с гибелью людей. Обслуживание подобных систем требует высоких материальных затрат, и всё же не исключает возможного возникновения сбоев. Это свидетельствует о том, что задача обеспечения надежности сложных многообъектных систем еще далека от своего решения. В связи с этим в настоящее время на первое место выходит задача обеспечения надежного функционирования систем при минимизации затрат на их содержание и техническое обслуживание. Решение которой невозможно без разработки и внедрения интеллектуальных систем, выполняющих функции предсказательной аналитики и предсказательного технического обслуживания. В данной статье предлагается гибридная нейросетевая модель прогнозирования отказов сложных многообъектных систем на основе классификационного подхода, направленная на повышение эксплуатационной надежности оборудования при минимальных затратах. Представлены результаты вычислительных экспериментов, подтверждающие высокую эффективность предложенного решения.

Scientific and technical progress has contributed to a rapid increase in the complexity of systems and their functions, which is especially characteristic of various fields of modern industry. Here, the cost of failure of equipment can be very high and sometimes lead to invaluable losses associated with the loss of life. Maintenance of such systems requires high material costs, but still does not exclude the possibility of failures. This indicates that the problem of ensuring the reliability of complex multi-object systems is still far from being solved. In this regard, the task of ensuring reliable operation of systems while minimizing the cost of their maintenance and maintenance is now in the first place. The solution of this problem is impossible without the development and implementation of intelligent systems that perform the functions of predictive analytics and predictive maintenance. This article proposes a hybrid neural network model for predicting failures of complex multi-object systems based on the classification approach, aimed at improving the operational reliability of equipment at minimal cost. The results of computational experiments confirming the high efficiency of the proposed solution are presented