bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis, characterization and application of a zirconium-based MOF-808 functionalized with isonicotinic acid for fast and efficient solid phase extraction of uranium(VI) from wastewater prior to its spectrophotometric determination
Authors: Sharifi-Rad Marzieh , Kaykhaii Massoud , Khajeh Mostafa , Oveisi Alireza
Published: April 2022

Background

A zirconium-based metal-organic framework (Zr-MOF), named MOF-808, was synthesized and fully characterized by solvo-thermal method and functionalized by isonicotinic acid and employed as an efficient adsorbent for selective extraction and preconcentration of uranyl ions from water and waste water samples in a batch solid phase extraction.

Results

Parameters affecting extraction such as volume and pH of the sample solution, the amount of sorbent, type and volume of eluting solvent, and adsorption and desorption times were investigated and optimized. Under the optimized conditions, high extraction efficiency was observed with a limit of detection of 0.9 µg L− 1 for uranyl ions and relative standard deviations were found to be better than 2.1% in the range of 0.07–1000 µg L− 1.

Conclusions

These results indicated that the above procedure is fast, inexpensive, effective, reliable, applicable and organic solvent-free and showed the highly performance and stability of the Zr-MOF in SPE based analytical techniques.
Methicillin-resistant Staphylococcus aureus enterocolitis in a 16-month-old boy: a case report
Authors: Loerke Christopher , Liebe Heather , Hunter Catherine J.
Published: April 2022

Background

Methicillin-resistant Staphylococcus aureus enterocolitis is a rare disease that typically affects immunocompromised adults. Most cases of pediatric enterocolitis are caused by Gram-negative bacteria, Gram-positive Clostridiodes difficile, or viruses. This is the first published case report of a toddler with methicillin-resistant Staphylococcus aureus enterocolitis.

Case presentation

A 16-month-old non-Hispanic White boy with no past medical or psychosocial history initially presented to the emergency room with abdominal pain and emesis. Past family history was pertinent only for his father having a history of constipation. He was diagnosed with intussusception and underwent successful contrast reduction on hospital day 0. The following day, the patient had recurrent symptoms and a repeat contrast enema showed no evidence of recurrent intussusception. A computed tomography scan was obtained, which was concerning for possible recurrence with compromised bowel. He was taken to the operating room for operative reduction and underwent an ileocecetomy with primary handsewn end-to-end anastomosis. His postoperative course was complicated by an anastomotic leak on hospital day 6 necessitating reoperation and creation of an end ileostomy with mucous fistula. He received intravenous metronidazole, ceftriaxone, and ceftazidime antibiotics during his hospital course. On postoperative day 12, the patient developed a sudden increase in ileostomy output, and stool cultures were obtained. His symptoms persisted despite diet modifications, stopping antibiotics, and initiating loperamide. Three days later, stool cultures resulted negative for Escherichia coli, Salmonella, Shigella, Campylobacter species, and Clostridiodes difficile but were positive for methicillin-resistant Staphylococcus aureus. The patient was started on a 10-day course of oral vancomycin and discharged home in good condition 4 days later. After 12 weeks, the patient underwent reversal of the ostomy and is doing well at the 1 month postoperative follow-up, now 5 months from his initial surgery.

Conclusions

To our knowledge, this is the first published report of a toddler being diagnosed with methicillin-resistant Staphylococcus aureus enterocolitis. Because methicillin-resistant Staphylococcus aureus enterocolitis is rare and has overlapping symptoms with more common gastrointestinal pathologies, it is often misdiagnosed. When a patient presents with diarrhea or high ostomy output along with fecal cultures negative for Clostridiodes difficile and other common pathogenic agents, methicillin-resistant Staphylococcus aureus should be considered.
Differentiation of an Iranian resistance chickpea line to Ascochyta blight from a susceptible line using a functional SNP
Authors: Zangene Kiyanoush , Emamjomeh Abbasali , Shokouhifar Farhad , Mamarabadi Mojtaba , Mehdinezhad Nafiseh
Published: April 2022

Identification of resistant sources to Ascochyta blight (AB) has been considered as a main purpose in most chickpea breeding programs. Achievements to molecular markers related to resistance to Ascochyta rabiei allows selection programs to be developed more accurately and efficiently. The aim of this study was to investigate the applicability of a functional SNP in differentiating Iranian resistant cultivars to be used in selection programs. Amplification of SNP-containing fragment with specific primer pair and its sequencing resulted in tracking and determining the allelic pattern of SNP18, SNP18-2147, SNP18-2491 and SNP18-2554 loci belong to GSH118 gene in ILC263 (sensitive) and MCC133 (resistant) chickpea lines. Mutations in SNP18 and SNP18-2147 occur at the protein level at positions 499 and 554. Bioinformatics studies have shown that the GSH118 gene is a Lucien-rich repeat receptor kinases (LRR-RKs) and encodes a membrane protein which can be involved in recognizing microorganisms and initiating immune signaling pathways in plants. Additional studies to determine the function of this gene and its interaction with other proteins can be effective in gaining more knowledge about the molecular basis of resistance against AB.
Artocarpesin acts on human platelet aggregation through inhibition of cyclic nucleotides and MAPKs
Authors: Kwon Hyuk-Woo , Irfan Muhammad , Lee Yuan Yee , Rhee Man Hee , Shin Jung-Hae
Published: April 2022

The cardiovascular diseases (CVDs) are becoming a critical threat to our lives in these years. It is now widely accepted that platelets play an important role in cardiovascular disease as they have a fundamental role in thrombosis. Therefore, many drugs or natural substances have been developed to treat CVDs. Cudrania tricuspidata is a regional plant containing various constituents, such as xanthones, flavonoids, organic acids, and polysaccharides. It has been widely used in East Asia as an important ethnomedicine for the treatment of many diseases such as eczema, mumps, tuberculosis and acute arthritis. Therefore, we evaluated antiplatelet effects using artocarpesin isolated from C. tricuspidata. Confirmation of the antiplatelet function of artocarpesin was made according to the following analyzes. Artocarpesin inhibited collagen-induced human platelet aggregation, calcium mobilization, glycoprotein IIb/IIIa activation and thrombin-induced clot retraction through the regulation of associated signaling molecules. Artocarpesin increased the phosphorylation of vasodilator-stimulated phosphoprotein (VASP) and inositol 1, 4, 5-triphosphate receptor I (IP3RI). On the other hand, the phosphorylation of cytosolic phospholipase A2 (cPLA2), mitogen-activated protein kinases p38, JNK and phosphoinositide 3-kinase (PI3K)/Akt decreased. Thus, the study highlights that artocarpesin has an inhibitory effect on platelet activity and thrombus formation, showing its potential value in preventing platelet-induced cardiovascular disease.
Therapeutic synergy of Triptolide and MDM2 inhibitor against acute myeloid leukemia through modulation of p53-dependent and -independent pathways
Authors: Chen Qinwei , Deng Suqi , Deng Manman , Shi Yuanfei , Zhong Mengya , Ding Lihong , Jiang Yuelong , Zhou Yong , Carter Bing Z. , Xu Bing
Published: April 2022

Dysregulation of MDM2, a p53 negative regulator, frequently occurs in acute myeloid leukemia (AML) and is associated with unfavorable prognoses, rendering the p53-MDM2 axis an attractive target for the development of small-molecule inhibitors. MDM2 antagonists have been intensely developed but only lead to limited clinical activity, suggesting combination with additional drugs is an unmet medical need. In this study, we reported that Triptolide synergized with MDM2 inhibitor Nutlin-3a to suppress cell proliferation and induce mitochondrial-mediated apoptosis in p53 wt AML in vitro and ex vivo. More importantly, Triptolide cooperated with Nutlin-3a to delay tumor growth and abrogate leukemia burden in an AML xenograft model. In addition, we observed that Triptolide and Nutlin-3a were also cooperative in part of p53 deficient cases. Mechanistically, Nutlin-3a upregulated the transcriptional expressions of the p53 downstream targets PUMA and p21, while Triptolide declined the mRNA levels of two anti-apoptotic factors, XIAP and Mcl-1, in p53 wt cells. These effects were more notable when Triptolide and Nutlin-3a were combined. Our results revealed that Triptolide monotherapy exerted its antileukemia effect via both p53-dependent and independent ways, with the latter through perturbation of the MYC-ATF4 axis-mediated ER stress. Collectively, these data suggested that the Triptolide-Nutlin-3a combination might be a novel potential therapeutic intervention for patients with AML and it warrants further clinical evaluations.
An actualized screening of schizophrenia-associated genes
Authors: Boulenouar Houssam , Benhatchi Hadjer , Guermoudi Farah , Oumiloud Ahlem Hania , Rahoui Asma
Published: April 2022

Background

Schizophrenia is a psychotic disorder that impacts around 0.5% to 1.2% of the world's population. It has been well established that heredity plays an essential role in the causation of schizophrenia, with genetic heritability of up to 80%. A several new schizophrenia susceptibility genes were identified at the start of the twenty-first century. The aim of this systematic review will be to explore the association between single nucleotide polymorphisms (SNPs) and schizophrenia risk in people all over the world.

Methods

This systematic review collected available data on genetic variants associated with schizophrenia in worldwide populations. A PubMed and Science Direct search was investigated to identify all studies published until December 2020 on genetic susceptibility to schizophrenia in various populations, excluding family studies, transversal studies, cohort studies, experimental studies, and descriptive studies; those that demonstrate an association between repeat polymorphism (CNV, VNTR, etc.). All researches on genetic predispositions of schizophrenia and accepting the predetermined inclusion criteria were included in this systematic review.

Findings

Thirty-six studies focused on the schizophrenia-associated genes were retained in which a total of 44 polymorphisms among 26 susceptibility genes to schizophrenia have been associated in the world populations.

Conclusion

Despite the few number of studies published about genetic of schizophrenia, some genetic variations have been consistently correlated to schizophrenia, particularly in China, as this analysis shows. Further data, especially from genome-wide association studies, might contribute in the development of a reference for schizophrenia genetic susceptibility markers.
Safety and Efficacy of Lonapegsomatropin in Children With Growth Hormone Deficiency: enliGHten Trial 2-Year Results
Authors: Maniatis Aristides K , Casella Samuel J , Nadgir Ulhas M , Hofman Paul L , Saenger Paul , Chertock Elena D , Aghajanova Elena M , Korpal-Szczyrska Maria , Vlachopapadopoulou Elpis , Malievskiy Oleg , Chaychenko Tetyana , Cappa Marco , Song Wenjie , Mao Meng , Mygind Per Holse , Smith Alden R , Chessler Steven D , Komirenko Allison S , Beckert Michael , Shu Aimee D , Thornton Paul S
Published: April 2022

Purpose

The objectives of the ongoing, Phase 3, open-label extension trial enliGHten are to assess the long-term safety and efficacy of weekly administered long-acting growth hormone lonapegsomatropin in children with growth hormone deficiency.

Methods

Eligible subjects completing a prior Phase 3 lonapegsomatropin parent trial (heiGHt or fliGHt) were invited to participate. All subjects were treated with lonapegsomatropin. Subjects in the United States switched to the TransCon hGH Auto-Injector when available. Endpoints were long-term safety, annualized height velocity, pharmacodynamics [insulin-like growth factor-1 SD score (SDS) values], and patient- and caregiver-reported assessments of convenience and tolerability.

Results

Lonapegsomatropin treatment during enliGHten was associated with continued improvements in height SDS through week 104 in treatment-naïve subjects from the heiGHt trial (−2.89 to −1.37 for the lonapegsomatropin group; −3.0 to −1.52 for the daily somatropin group). Height SDS also continued to improve among switch subjects from the fliGHt trial (−1.42 at fliGHt baseline to −0.69 at week 78). After 104 weeks, the average bone age/chronological age ratio for each treatment group was 0.8 (0.1), showing only minimal advancement of bone age relative to chronological age with continued lonapegsomatropin treatment among heiGHt subjects. Fewer local tolerability reactions were reported with the TransCon hGH Auto-Injector compared with syringe/needle.

Conclusions

Treatment with lonapegsomatropin continued to be safe and well-tolerated, with no new safety signals identified. Children treated with once-weekly lonapegsomatropin showed continued improvement of height SDS through the second year of therapy without excess advancement of bone age.
Spine Volumetric BMD and Strength in Premenopausal Idiopathic Osteoporosis: Effect of Teriparatide Followed by Denosumab
Authors: Agarwal Sanchita , Shane Elizabeth , Lang Thomas , Shiau Stephanie , Kamanda-Kosseh Mafo , Bucovsky Mariana , Lappe Joan M , Stubby Julie , Recker Robert R , Hu Yizhong , Wang Zexi , Edward Guo X , Cohen Adi
Published: April 2022

Context

Premenopausal women with idiopathic osteoporosis (PreMenIOP) have marked deficits in bone density, microstructure, and strength.

Objective

To define effects of treatment with teriparatide followed by denosumab on lumbar spine (LS) volumetric bone mineral density (vBMD) and stiffness by finite element analysis assessed on central quantitative computed tomography (cQCT) scans.

Design, Settings, and Participants

Ancillary analysis of baseline, post-teriparatide, and post-denosumab cQCT scans from a randomized trial of 41 women allocated to teriparatide (20 mcg daily; n = 28) or placebo (n = 11). After 6 months, those on teriparatide continued for 18 months, and those on placebo switched to teriparatide for 24 months. After completing teriparatide, 33 enrolled in a Phase 2B extension with denosumab (60 mg every 6 months) for 12 months.

Main Outcome Measures

Primary outcomes were percentage change from baseline in LS trabecular vBMD and stiffness after teriparatide and between end of teriparatide and completing denosumab. Percentage change from baseline in LS trabecular vBMD and stiffness after sequential teriparatide and denosumab were secondary outcomes.

Findings

There were large increases (all Ps < 0.001) in trabecular vBMD (25%), other vBMD parameters, and stiffness (21%) after teriparatide. Statistically significant increases in trabecular vBMD (10%; P < 0.001) and other vBMD parameters (P = 0.03-0.001) were seen after denosumab, while stiffness increased by 7% (P = 0.068). Sequential teriparatide and denosumab led to highly significant (all Ps < 0.001) increases LS trabecular vBMD (43%), other vBMD parameters (15-31%), and stiffness (21%).

Conclusions

The large and statistically significant increases in volumetric density and stiffness after sequential treatment with teriparatide followed by denosumab are encouraging and support use of this regimen in PreMenIOP.
Insulin Sensitivity and Metabolic Flexibility Parallel Plasma TCA Levels in Early Chronotype With Metabolic Syndrome
Authors: Remchak Mary-Margaret E , Heiston Emily M , Ballantyne Anna , Dotson Brielle L , Stewart Nathan R , Spaeth Andrea M , Malin Steven K
Published: April 2022

Context

People characterized as late chronotype have elevated type 2 diabetes and cardiovascular disease risk compared to early chronotype. It is unclear how chronotype is associated with insulin sensitivity, metabolic flexibility, or plasma TCA cycle intermediates concentration, amino acids (AA), and/or beta-oxidation.

Objective

This study examined these metabolic associations with chronotype.

Methods

The Morningness-Eveningness Questionnaire (MEQ) was used to classify adults with metabolic syndrome (ATP III criteria) as either early (n = 15 [13F], MEQ = 64.7 ± 1.4) or late (n = 19 [16F], MEQ = 45.5 ± 1.3) chronotype. Fasting bloods determined hepatic (HOMA-IR) and adipose insulin resistance (Adipose-IR) while a 120-minute euglycemic clamp (40 mU/m2/min, 5 mmoL/L) was performed to test peripheral insulin sensitivity (glucose infusion rate). Carbohydrate (CHOOX) and fat oxidation (FOX), as well as nonoxidative glucose disposal (NOGD), were also estimated (indirect calorimetry). Plasma tricarboxylic acid cycle (TCA) intermediates, AA, and acyl-carnitines were measured along with VO2max and body composition (DXA).

Results

There were no statistical differences in age, BMI, fat-free mass, VO2max, or ATP III criteria between groups. Early chronotype, however, had higher peripheral insulin sensitivity (P = 0.009) and lower HOMA-IR (P = 0.02) and Adipose-IR (P = 0.05) compared with late chronotype. Further, early chronotype had higher NOGD (P = 0.008) and greater insulin-stimulated CHOOX (P = 0.02). While fasting lactate (P = 0.01), TCA intermediates (isocitrate, α-ketoglutarate, succinate, fumarate, malate; all P ≤ 0.04) and some AA (proline, isoleucine; P = 0.003-0.05) were lower in early chronotype, other AA (threonine, histidine, arginine; all P ≤ 0.05) and most acyl-carnitines were higher (P ≤ 0.05) compared with late chronotype.

Conclusion

Greater insulin sensitivity and metabolic flexibility relates to plasma TCA concentration in early chronotype.
Deficiency of C1QL1 Reduced Murine Ovarian Follicle Reserve Through Intraovarian and Endocrine Control
Authors: Lu Xiaosheng , Ding Fei , Chen Yao , Ke Shiyun , Yuan Shaochun , Qiu Han , Xiao Luanjuan , Yu Yanhong
Published: April 2022

Ovarian aging is associated with depletion of the ovarian follicle reserve, which is the key determinant of fertility potential in females. In this study, we found that the small, secreted protein complement 1Q-like (C1QL1) is involved in the regulation of follicle depletion through intraovarian and endocrine control in a multidimensional collaborative manner. C1ql1 was detected to be conserved in the ovary and showed high transcript levels during folliculogenesis. Blockade of C1QL1 by IP and ovarian intrabursal injection of C1QL1 antiserum into prepubertal mice impaired folliculogenesis accompanied by reductions in body weight, fat mass, and intraovarian lipid accumulation. An elevation of circulating estradiol levels, reduction of hypothalamic KISS1 and GnRH expression, and a decrease in serum FSH levels were found in C1QL1-deficient mice. In C1QL1-deficient ovaries, many primordial follicles were recruited and developed into medium follicles but underwent atresia at the large follicle stages, which resulted in depletion of follicle reserve. Depletion of C1QL1 alleviated the inhibitory effect of C1QL1 on granulosa cell apoptosis and the stimulatory effect of C1QL1 on granulosa cell autophagy, which resulted in accumulation in the preantral and early antral follicles and an increase in the atretic follicles. The abnormal profile of endocrine hormones accelerated the intraovarian effect of C1QL1 deficiency and further led to depletion of ovarian reserve. Altogether, this study revealed the expression patterns and the mechanism of action of C1QL1 during folliculogenesis and demonstrated that deficiency of C1QL1 caused ovarian follicular depletion.
Design of Fuzzy Economic Order Quantity (EOQ) Model in the Presence of Inspection Errors in Single Sampling Plans
Authors: Thomas Julia T. , Kumar Mahesh
Published: April 2022

Inventory management is the core of the supply chain management system, in which the economic order quantity (EOQ) model is a fundamental inventory model. This paper develops a fuzzy EOQ model in the presence of inspection errors in single sampling plans. The model assumes probability of mis-classifications. An inventory system is hypothesized where the orders undergo acceptance sampling, back-orders are eliminated, and defectives are set aside from the inventory. Due to the presence of vagueness in real time data, the rate at which an order turn to be scrap, the costs of holding, and the back-orders are characterized by fuzzy random variables. Since total profit involved is a random variable, maximum total expected profit is obtained. Some numerical examples are presented, and a sensitivity analysis study is carried out to check the validity of the model developed.
Provincial Administration in Crisis and Emergency Managament in Turkey
Authors: Çapar Selim , Koca Mehmet
Published: April 2022

The unexpected and extraordinary situations such as typhoon, flood, earthquake, volcano eruption, nuclear, epidemic, chemical and biological substances threatening human health, accidents related to airline, sea or highway transportations, terrorist attacks, widespread act of force, risk of war as well as extraordinary developments in monetary and financial markets are generally considered among the causes of crisis.

Due to different factors such its geographical location, geological structure, the characteristics of the settlements and the inconvenience of the existing building stock, Turkey is often faced with disasters and state of emergencies.

The Ministry of Interior is responsible and authorized for both ensuring the public order and security in Turkey and for disaster management throughout the country. In the provinces and districts within the provincial administration system. The provincial administrators working as the representative of the central administration are responsible and authorized. The provincial executives undertake the function of “lifeguard in extraordinary situations”. Unlike the other professions, provincial executives fulfill their leadership and organizational duties both on the institutions and organizations affiliated to them, and the personnel working in these units and also on the management of crisis, disasters and emergency situations. In this study, the duties and responsibilities of provincial executives in the management of crisis and emergency situations in Turkey and the capacity of provincial executives to manage crises and emergency situations are presented.
Structure of Turkish leisure industry
Authors: Şmşek Kerem Yıldırım
Published: April 2022

The potential of a society or the developed facilities can play a central role for improving the economy of a country. The leisure industry has been growing to be a giant industry that can contribute to Turkey’s economy which is placed in low ranks of the better life index between Organisation for Economic Co-operation and Development (OECD) countries. However, one of the most significant elements that slow down the progress in Turkey is that the professional competence framework has not been drawn leading to problems in the employment of professional specialists. The guiding element for the determination of the professional competence framework is a model that can define the industrial dimensions related with the profession.
The models and literature knowledge for the leisure industry has been found limited when the international literature is examined. In the scope of this research, four leisure models that were stated within international literature were examined and a new model that would be suitable for the Turkish leisure industry was proposed in the light of previous models. In addition, the Turkish leisure industry was discussed in detail in order to fill the deficiency within international literature about Turkish leisure industry.
​Extended English summary is in the end of Full Text PDF (TURKISH) file.
Özet
 
Bir toplumun sahip olduğu potansiyel ya da geliştirdiği olanaklar, ülke ekonomisinin daha iyi olması için merkezi bir rol üstlenebilir. Ekonomik Kalkınma ve İşbirliği Örgütü (OECD) ülkelerinin daha iyi yaşama indeksi sıralamasında alt sıralarda olan Türkiye için rekreasyon endüstrisi gelecekte ülke ekonomisine önemli katkılar sağlayabilecek dev bir endüstri olma yolunda ilerlemektedir. Ancak Türkiye’deki bu ilerlemeyi yavaşlatan en önemli unsurlardan biri meslek uzmanlarının istihdamında sorun yaratan mesleki yeterlilik çerçevesinin henüz çizilememiş olmasıdır. Mesleki yeterlilik çerçevesinin belirlenmesinde kılavuz unsur ise meslekle ilişkili endüstriyel boyutları tanımlayabilen model olabilir.
Uluslararası literatür incelendiğinde rekreasyon endüstrisine yönelik model ya da literatür bilgisi sınırlı durumdadır. Araştırma kapsamında uluslararası literatürde ön plana çıkmış dört rekreasyon modeli incelenmiş ve bu modeller doğrultusunda Türk rekreasyon endüstrisinin yapısına uygun bir model önerilmiştir.
A Green Heterogeneous Catalyst Production and Characterization for Biodiesel Production using RSM and ANN Approach
Authors: Kolakoti Aditya , Setiyo Muji , Rochman Muhammad Latifur
Published: April 2022

In this work, naturally available moringa oleifera leaves (also known as horseradish trees or drumstick trees) are chosen as a heterogeneous catalyst in the transesterification for biodiesel production from palm oil. The dry moringa oleifera leaves are calcinated at 700 °C for 3 hours to improve their adsorbing property. The calcinated catalyst characterization analysis from XRD and EDX highlights the presence of calcium, potassium, and other elements. Response surface method (RSM) optimization and artificial neural network (ANN) modeling were carried out to elucidate the interaction effect of significant process variables on biodiesel yield. The results show that a maximum biodiesel yield of 92.82% was achieved at optimum conditions of catalyst usage (9 wt.%), molar ratio, methanol to triglyceride (7:1), temperature (50 °C) and reaction time (120 min). The catalyst usage (wt.%) was identified as a significant process variable, followed by the molar ratio. Furthermore, the biodiesel’s significant fuel properties in terms of thermal, physical, chemical, and elemental match the established standards of ASTM. Finally, when the catalyst was reused for five cycles, more than 50% of the biodiesel yield was achieved.
Experimental Investigation of Bladeless Power Generator from Wind-induced Vibration
Authors: Barata La Ode Ahmad , Takahiro Kiwata , Ueno Toshiyuki , Samhuddin Samhuddin , Hasanudin La
Published: April 2022

The power harvester unit from flow-induced vibration (FIV) was designed to harness energy from low flow velocity based on the magnetostrictive effect on the galfenol (Fe – Ga alloy) strip induced by the oscillating bluff body. This study aimed to investigate the cross-section variation’s effect on the FIV characteristics and the magnetostrictive material’s performance for the bladeless power generator. The generator model’s vibration characteristics and performance tests were conducted in the wind tunnel test using the wind-receiving unit (WRU) variation. The results showed that the resonance reduced-velocity (Vr) were around 3.7 and 4.0 for rectangular and circular cylinders, respectively. Furthermore, the effect of rectangular depth variation on the power generation output is linear to the test models’ displacement rate and vibration frequency. The harvester’s maximum power generation was 5.25 mW, achieved using the rectangular prism with depth D = 0.4H. The power coefficient was also evaluated for different wind-receiving models. The harvester model lit up 54 LED lamps in the wind tunnel test. The voltage output is sufficient to provide electric power resources for an IoT system, sensor, and wearable or wireless devices. The harvester model successfully generated a voltage signal under the initial field test with an ambient wind velocity of 0.9 – 2.71 m/s. Therefore, this study recommends the development of bladeless power generators in the future.
Religious Ideology Plurality of IAIN Kendari Students
Authors: M Zulkifli , Insawan Husain
Published: April 2022

This study aims to describe the plurality of religious ideologies of IAIN Kendari students. The method used is descriptive qualitative with data analysis techniques, interviews and documentation, while data analysis is data collection, reduction, discussion, and conclusion. The results showed that: The plurality of religious ideology of IAIN Kendari students was (a) Persyarikatan Muhammadiyah as a movement to purify Islamic teachings through da'wah makruf nahi munkar preaching, building society in various aspects, both in the fields of aqeedah, worship, social, education, health and technology ; (b) Nahdhatul Ulama is engaged in the fields of religion, education, social, economy, adhering to the Ahlussunnah waljama'ah concept, sourced from al-Qur'an, sunnah, which is a Shafi'i school; (c) Tabligh Jamaah is a global education and missionary movement with the principle of kalimah tauhid, upholding salât, knowledge and dhikr, glorifying every Muslim, sincere, improving intentions, preaching to Allah and khuruj in His way with tabligh; (d) The Muslim Brotherhood has a Sunni ideology, Islamic democracy, and religious conservatism, realizing the formation of individual Muslim, household, nation and Islamic government figures; (e) Indonesian Islamic Da'wah Institution is based on the spirit of carrying out the teachings of Islam based on Al- Qur'an and Al-Hadith, through the implementation of mahdhah and ghairu mahdhah worship as the implementation of human position towards Al-Khaliq by worshiping solely to Him; (f) The Salafi movement returns to the teachings of Islam as exemplified by the Prophet seeing his friends, tabi'in and tabi’ut tabi’in; (2) Plurality map of religious ideology in IAIN Kendari students in various understandings, Muhammadiyah, Nahdhatul Ulama, Tablighi Jamaah, Muslim Brotherhood, Indonesian Islamic Da'wah Institution, and Salafi; (3) The factors that influence are internal factors, the influence of fellow students on Islamic studies, the socio- cultural background of students' economics.
Chemtrails and Covid-19: Two Faces of Evil
Authors: Whiteside Mark , Herndon J. Marvin
Published: April 2022

Chemtrails and Covid-19, two faces of Evil, threaten all life on our planet solely for political reasons. If we are to have a viable future on this planet, a critical mass of humanity must wake up to the atrocities of the ongoing chemtrail and biological operations. People must break out of their mass formation hypnosis and distractions, start to look up, and bear witness to the terrible suffering of the natural world around us. We are not separate entities from the rest of the biosphere: if the forests die, the wildlife dies, and the oceans die, we too will die. Our time is short – action is urgently needed now to salvage what remains of our natural life support systems and give our children a healthy and viable future.
A Framework for Testing the Reliability and Validity of a Novel Non-Invasive Digital Biomarker Instrument Using Statistical Techniques: A Case Study with Lyfas
Authors: Chattopadhyay Subhagata , Das Rupam
Published: April 2022

Background: This paper demonstrates a framework for testing of efficacy (reliability and validity) of a novel instrument against a gold-standard instrument. Lyfas is a novel, non-wearable, non-invasive, and economic optical biomarker instrument that runs on android smartphones. By capturing the Pulse Rate (PR) and Pulse Rate Variability (PRV) from the index finger capillary using photoplethysmography, it measures the Cardiovascular Autonomic Modulation (CvAM). The Polar H10 sensor is a gold-standard electrical biofeedback instrument that comes with a wearable chest belt and is a relatively costly device. It captures the Heart Rate (HR) and Heart Rate Variability (HRV) that surrogates Cardiac Autonomic Modulation (CAM). Objective: To showcase the statistical framework in mining the efficacy of Lyfas as a biofeedback instrument by comparing it with that of the Polar H10 instrument following a ‘6Minute Walk Test’. Method: Using Lyfas and Polar H10 HR sensor, PR and HR were captured from 567 subjects(n=567, 312 healthy adult males, and 255 females, respectively). The data was checked for the (a) internal consistency (Cronbach’s alpha), (b) its distribution (Q-Q plots), (c) descriptive statistics (box plots), (d) Root Mean Square difference between the HR and PR, (e) reliability (Bland-Altman Reliability Test), and (f) correlations using (i) Pearson’s inter-class correlations (r), and (ii) Linear regressions (R2). Results: The efficacy of Lyfas as a biofeedback instrument has finally been computed by averaging the mean scores of BART (93.53%), ‘r’ (86.96%), and R2 (87.58%) for the sample and found to be 87.27%. Conclusion: Lyfas can also be used as a biofeedback instrument.
An Introduction to Data Encryption and Future Trends in Lightweight Cryptography and Securing IoT Environments
Authors: Bagui Sikha , Galliera Raffaele
Published: April 2022

This paper presents an overview of the basic concepts of cryptography and encryption. The work aims at presenting the main concepts and concerns of encryption on a high-level of abstraction, allowing non-domain expert readers to navigate through these topics. Less traditional arguments are also shown, from the relevance of Key Management Services with its usage in Envelope Encryption, to Zero Knowledge proofs and their innovative applications. The crucial importance of securing communications between IoT devices and widely used algorithms to do so, are also discussed.
PCSK9 and LRP6: potential combination targets to prevent and reduce atherosclerosis
Authors: Desita Saskia R. , Hariftyani Arisvia S. , Jannah Ayik R. , Setyobudi Assyadila K. , Oktaviono Yudi H.
Published: April 2022

Coronary artery disease (CAD) is a disease characterized by atherosclerosis formation which causes sudden cardiac death. The prevalence of CAD is expected to increase by 2030. Atherosclerosis started from accumulation of LDL in the blood vessels, followed by endothelial cell activation and dysfunction. PCSK9 is a gene that plays an important role in the creation of atherosclerotic plaque through induced degradation of LDLRs. Inhibition of PCSK9 gene resulted in a decrease of LDLRs degradation and reduction in LDL-C levels. LRP6, as well as its mutation, is a coreceptor that contributes to atherosclerosis through the canonical Wnt/β-catenin pathway. By employing EMPs mediated miRNA-126, third-generation antisense against miR-494-3p (3 GA-494), and recombinant Wnt mouse Wnt3a (rmWnt3a), the inhibition of LRP6 could reduce VSMCs proliferation, enhancing anti-inflammatory macrophages, and diminished bioactive lipids component, respectively. Those mechanisms lead to the stabilization and reduction of atherosclerosis plaques.
Experimental and numerical investigation of drop weight impact of aramid and UHMWPE reinforced epoxy
Authors: Hassoon Omar H. , Abed Mayyadah S. , Oleiwi Jawad K. , Tarfaoui M.
Published: April 2022

Due to their characteristics such as weight/strength ratio and absorbed energy, the widespread use of composite materials in the last decades engorged the companies to exploit these materials invariant applications like the aerospace, automobile, and marine hull. However, there are some obstructs to the use of these materials that may constrain that. This came from the fact, that composite materials suffer from different damages modes that occur during loading and can be lead to catastrophic failure in their structure, such as intralaminar and interlaminar damage. Consequently, this motivated the researchers to study its behavior considering different damage modes and at different loading states. This work performed a finite element simulation using the Abaqus program of low-velocity drop impact for epoxy reinforced with Kevlar 49 and Ultra High Molecular Weight Polyethylene (UHMWPE) with different thicknesses and number of layers. A user-defined material VUMAT subroutine-based progressive damage model, and the Hashin failure criteria implemented in Abaqus Explicit finite element code had been utilized in this work. In Addition, the interlaminar damage models depend on the cohesive zone model (CZM). The numerical simulation results were compared with the experiments data to confirm the reliability of the numerical model.
Spectroscopic ellipsometry for low-dimensional materials and heterostructures
Authors: Yoo SeokJae , Park Q-Han
Published: April 2022

Discovery of low-dimensional materials has been of great interest in physics and material science. Optical permittivity is an optical fingerprint of material electronic structures, and thus it is an important parameter in the study of the properties of materials. Spectroscopic ellipsometry provides a fast, robust, and noninvasive method for obtaining the optical permittivity spectra of newly discovered materials. Atomically thin low-dimensional materials have an extremely short vertical optical path length inside them, making the spectroscopic ellipsometry of low-dimensional materials unique, compared to traditional ellipsometry. Here, we introduce the fundamentals of spectroscopic ellipsometry for two-dimensional (2D) materials and review recent progress. We also discuss technical challenges and future directions in spectroscopic ellipsometry for low-dimensional materials.
General elections in Serbia - 2022
Authors:   Institute of Europe of Russian Academy Sciences, Entina Ekaterina , Eremin Denis
Published: April 2022

On 3 April 2022, Serbia held general elections. They included presidential, early parliamentary and municipal elections. While the outcome was generally predictable, Russia's special military operation in Ukraine played a significant role in the specific outcome and had a significant impact on the Serbian electorate. Its results demonstrate that the party and political system of Serbia will transform in the nearest future. So far, Serbia remains the only European country that has not joined the sanctions against Russia. The ability to maintain this position in the future depends seriously not only on Belgrade, but also on Moscow.
THE STAGE OF THE SPECIAL MILITARY OPERATION IN UKRAINE. THE ANATOMY OF THE ANTI-RUSSIA POLICY IN EUROPE
Authors:   Institute of Europe, Russian Academy of Sciences, Аyvazyan Аnna , Alekseenkova Еlena ,   Institute of Europe, Russian Academy of Sciences, Ananieva Elena ,   Institute of Europe, Russian Academy of Sciences, Babynina Ludmila ,   Institute of Europe, Russian Academy of Sciences, Belov Vladislav ,   Institute of Europe, Russian Academy of Sciences, Godovanyuk Kira ,   Institute of Europe, Russian Academy of Sciences, Gromyko Aleksey ,   Institute of Europe, Russian Academy of Sciences, Gusev Kirill ,   Institute of Europe, Russian Academy of Sciences, Danilov Dmitriy ,   Institute of Europe, Russian Academy of Sciences, Domanov Aleksey ,   Institute of Europe, Russian Academy of Sciences, Kondratieva Natalia ,   Institute of Europe, Russian Academy of Sciences, Lunkin Roman ,   Institute of Europe, Russian Academy of Sciences, Mezhevich Nikolay ,   Institute of Europe, Russian Academy of Sciences, Nadzharov Aleksandr ,   National Research University Higher School of Economics, Narochnitskaya Ekaterina ,   Institute of Europe, Russian Academy of Sciences, Oskolkov Pert ,   Institute of Europe, Russian Academy of Sciences, Okhoshin Oleg ,   Institute of Europe, Russian Academy of Sciences, Potemkina Olga ,   Institute of Europe, Russian Academy of Sciences, Roginko Sergey ,   Institute of Europe, Russian Academy of Sciences, Rubinskiy Yuri ,   Institute of Europe, Russian Academy of Sciences, Fedorov Sergey ,   Institute of Europe, Russian Academy of Sciences, Shimov Vsevolod ,   Belarusian State Universityv, Entina Ekaterina ,   Institute of Europe, Russian Academy of Sciences
Published: April 2022

The collective study presents the results of an endevour of a team of historians, political scientists, economists of the Institute of Europe (Russian Academy of Sciences), with participation of specialists from some other research centres. The goal of this research is to explore in a comprehensive way the events unfolding in Europe after the Russian Federation recognised the independence of Donetsk Peoples Republic and Lugansk Peoples Republic and the special military operation was started in Ukraine. The fundamental goal of the operation is the protection of the citizens of DPR and LPR, demilitarisation and denazification of Ukraine. The book contains analysis of the reaction to these decisions focusing on the European Union, NATO, Council of Europe, major European countries, selected partner states of Russia in the CIS, the Russian Orthodox Church.
Pull Up a Chair, Sit Down, and Listen
Authors: Tribble Curt
Published: April 2022

When I was a medical student rotating on the various clinical services and thinking about career decisions, a common refrain from those offering advice on these decisions was that an early ‘branch in the career decision tree’ was deciding whether you liked caring for patients or liked doing procedures. I sensed that this advice was creating, or at least suggesting, a false or inaccurate choice. In fact, I even remember hearing that surgeons should not get too close to their patients in order to retain a sense of detachment. Somehow I just didn’t see it that way.
PLAcental Circulation and pre-Eclampsia outcomes uNder the Treatment with Arginine (PLACENTA): а multicenter randomized controlled trial
Authors:   Republican Specialized Scientific and Practical Medical Center of Obstetrics and Gynecology Ministry of Health of the Republic of Uzbekistan, Tashkent, En-Din Kim , Nishanova F.P. ,   Republican Specialized Scientific and Practical Medical Center of Obstetrics and Gynecology Ministry of Health of the Republic of Uzbekistan, Tashkent, Karimov A.Kh. ,   Tashkent Medical Academy, Tashkent, Liubchich A.S. ,   Republican Perinatal Center of the Republic of Uzbekistan, Tashkent
Published: April 2022

The objective: to evaluate the effectiveness of L-arginine in the correction of dysfunction in the utero-placental-fetal complex, intrauterine development of the fetus and the condition of the newborn in the early period of adaptation. Materials and methods. A prospective double-blind, randomized, multicenter controlled clinical trial was carried out at the Republican Specialized Scientific and Practical Medical Center of Obstetrics and Gynecology, II Clinic of the Tashkent Medical Academy and the Republican Perinatal Center of the Ministry of Health of the Republic of Uzbekistan. Results. Treatment with L-arginine in women at the end of the second and beginning of the third trimester of pregnancy with chronic diseases complicated by placental dysfunction improves perinatal outcomes, leads to a decrease in the number of premature births and asphyxiation of newborns. Conclusion. The use of L-arginine in the treatment of preeclampsia and correction of disorders in the utero-placental-fetal complex significantly improves the utero-placental-fetal blood flow. This allows to prolong the pregnancy to the optimal term of delivery. Key words: utero-placental-fetal blood flow, placental dysfunction, fetoplacental insufficiency, pregnant women, newborns, correction, therapy, L-arginine, Tivortin.
Retrospective analysis of antenatal fetal death cases in a typical Kiev maternity hospital
Authors:   Bogomolets National Medical University, Kyiv, Ukraine, Hychka N.M. , Benyuk V.O. ,   Bogomolets National Medical University, Kyiv, Ukraine, Kotenok A.S. ,   Bogomolets National Medical University, Kyiv, Ukraine,
Published: April 2022

In this work, cases of antenatal fetal death in the Kyiv City Maternity Hospital No. 3 for 2014-2018 are analyzed. It is established, by means of a retrospective study, of high-risk groups in pregnant women in the antenatal period. The objective: on the basis of the analysis of cases of antenatal fetal death in the KСMH number 3 for 2014–2018, to determine the high-risk group of pregnant women in the occurrence of this pathology. Materials and methods. To achieve the goal, an analysis of medical records (exchange births, birth histories, results of the pathologic-anatomical conclusion, reviews) of cases of antenatal fetal death in the KCMH № 3 for 2014–2018 was conducted. Results. 68 cases of antenatal fetal death over the past 5 years in the Kyiv City Maternity Hospital No. 3 have been analyzed. The average frequency of antenatal death per 5 years per 1000 genera is 4‰. The greatest proportion of antenatal fetal death occurs during pregnancy up to 37 weeks. The causes of stillbirth in this period were mainly premature detachment of the placenta against the background of late gestosis, fetal malformations, and fetoplacental insufficiency. The largest number of cases of antenatal fetal death occurred at the age of 30 - 34 years. All women in this age group have obsessive-gynecological history - involuntary miscarriage or stopped pregnancy. Pregnant women of this group began to be registered in pregnancy after 12 weeks (n=17), which indicates the lack of preconceptual preparation and lifestyle correction in the early stages of pregnancy. Conclusions. Thus, we have established an average index of the frequency of antenatal fetal death in the KCMH № 3 for 2014–2018, which is 4 ‰, indicating timely, adequate provision of medical care.It is necessary to perform a comprehensive examination of women in the pregraviderm period, pregnant women, to evaluate the fetus’s fetal condition, to use pregnancy counseling by related specialists. Key words: population growth, antenatal mortality, stillbirth, critical periods of pregnancy.
Peculiarities of heart and vascular remodeling in the females with hypertension depending on obesity grade
Authors:   Sumy State University, Ukraine, Kyrychenko N.M.
Published: April 2022

The objective: was to establish the peculiarities of heart and vascular remodeling in the females with hypertension and obesity of different grades. Materials and methods. We examined 142 patients with hypertension at the age of 40–60 years. The first group included 25 patients with normal body weight, the second – 45 patients with grade 1obesity, the third group – 45 patients with grade 2obesity, and the fourth – 27 patients with grade 3 obesity. Results. As a result of the conducted research, it is established that the values of the studied parameters in patients with normal body weight and grade 1obesitydo not have a significant difference. In patients with grade 2 obesity, the size of the intima-media complex is statistically significantly higher, and the degree of endothelium-dependent vasodilation of the shoulder arteries is less than in patients with normal body weight. Unlike other groups, the patients with grade 3 obesity have the intima-media complex thickness, their pulse wave velocity in the carotid arteries and the abdominal aorta and the final diastolic size of the left ventricle of the heart are higher, but the endothelium-dependent vasodilation degree of the brachial arteries is significantly less. Conclusion. With the increase of the body weight, hypertensive females tend to increase the average pressure in the pulmonary artery and decrease the left ventricular ejection fraction. Key words: hypertension, obesity, heart and vascular remodeling.