bluuebunny/crossref_metadata_2025 huggingface dataset:
Feeling matters: Perceived Social Support Moderate the Relationship between Personal Relative Deprivation and Depressive Symptoms
Authors: Zhao Sibo , Peng Li
Published: April 2021

Background Little research describes the mechanisms underlying depressive symptoms and personal relative deprivation in Chinese populations. Methods In this study, the respondents were (N = 938) residents of Beijing (17-59 years old) and robust multiple linear regressions were used to assess the main relationship between relative deprivation and depressive symptoms and social support as a potential moderator for that relationship. Results Individuals who reported higher personal relative deprivation had greater depressive symptoms than those who reported lower personal relative deprivation. Perceived social support buffered the relationship between depressive symptoms and personal relative deprivation. Conclusions The findings of this current study demonstrate the importance of relative deprivation for psychological strain and income in explaining how socioeconomic indices correlate with depressive symptoms. They also demonstrate the need to acknowledge the interaction of perceived social support and personal relative deprivation for influencing depression.
BMI Trajectory in Childhood Is Associated With Asthma Incidence at Young Adulthood Mediated by DNA Methylation
Authors: Patel Rutu , Zhang Hongmei , Karmaus Wilfried , Ewart Susan , Relton Caroline , Ring Susan , Arshad S. Hasan , Holloway John W
Published: April 2021

Purpose: Body mass index (BMI) is associated with asthma but associations of BMI temporal patterns with asthma incidence are unclear. Previous studies suggest that DNA methylation (DNAm) is associated with asthma status and variation in DNAm is a consequence of BMI changes. This study assessed the direct and indirect (via DNAm) effects of BMI trajectories in childhood on asthma incidence at young adulthood. Methods: Data from the Isle of Wight (IoW) birth cohort were included in the analyses. Group-based trajectory modelling was applied to infer latent BMI trajectories from ages 1 to 10 years. An R package, ttscreening, was applied to identify differentially methylated CpGs at age 10 years associated with BMI trajectories, stratified for sex. Logistic regressions were used to further exclude CpGs with DNAm at age 10 years not associated with asthma incidence at 18 years. CpGs discovered via path analyses that mediated the association of BMI trajectories with asthma incidence in the IoW cohort were further tested in an independent cohort, the Avon Longitudinal Study of Children and Parents (ALSPAC).Results: Two BMI trajectories (high vs. normal) were identified. Of the 442,474 CpG sites, DNAm at 159 CpGs in males and 212 in females were potentially associated with BMI trajectories. Assessment of their association with asthma incidence identified 9 CpGs in males and 6 CpGs in females. DNAm at 4 of these 15 CpGs showed statistically significant mediation effects (p-value<0.05). At two of the 4 CpGs (cg23632109 and cg10817500), DNAm completely mediated the association (i.e., only statistically significant indirect effects were identified). In the ALSPAC cohort, at all four CpGs, the same direction of mediating effects were observed as those found in the IoW cohort, although statistically insignificant.Conclusion: The association of BMI trajectory in childhood with asthma incidence at young adulthood is possibly mediated by DNAm.
Protecting Security-Sensitive Data Using Program Transformation and Trusted Execution Environment
Authors: Faree Anter Abdu Alhag Ali , Wang Yongzhi
Published: April 2021

Cloud computing allows clients to upload their sensitive data to the public cloud and perform sensitive computations in those untrusted areas, which drives to possible violations of the confidentiality of client sensitive data. Utilizing Trusted Execution Environments (TEEs) to protect data confidentiality from other software is an effective solution. TEE is supported by different platforms, such as Intel’s Software Guard Extension (SGX). SGX provides a TEE, called an enclave, which can be used to protect the integrity of the code and the confidentiality of data. Some efforts have proposed different solutions in order to isolate the execution of security-sensitive code from the rest of the application. Unlike our previous work, CFHider, a hardware-assisted method that aimed to protect only the confidentiality of control flow of applications, in this study, we develop a new approach for partitioning applications into security-sensitive code to be run in the trusted execution setting and cleartext code to be run in the public cloud setting. Our approach leverages program transformation and TEE to hide security-sensitive data of the code. We describe our proposed solution by combining the partitioning technique, program transformation, and TEEs to protect the execution of security-sensitive data of applications. Some former works have shown that most applications can run in their entirety inside trusted areas such as SGX enclaves, and that leads to a large Trusted Computing Base (TCB). Instead, we analyze three case studies, in which we partition real Java applications and employ the SGX enclave to protect the execution of sensitive statements, therefore reducing the TCB. We also showed the advantages of the proposed solution and demonstrated how the confidentiality of security-sensitive data is protected.
Efficacy of repetitive transcranial magnetic stimulation (rTMS) for reducing consumption in patients with alcohol use disorders (ALCOSTIM): study protocol for a randomized controlled trial
Authors: Petit Benjamin , Soudry-Faure Agnès , Jeanjean Ludovic , Lalanne Laurence , Foucher Jack , Carpentier Maud , Jonval Lysiane , Allard Coralie , Ravier Mathilde , Mohamed Amine Ben , Meille Vincent , Trojak Benoit
Published: April 2021

Background: The number of people with an alcohol use disorder (AUD) was recently estimated to be 63.5 million worldwide. The global burden of disease and injury attributable to alcohol is considerable: about 3 million deaths, namely one in 20, were caused by alcohol in 2015. At the same time, AUD remains seriously undertreated.In this context, alternative or adjunctive therapies such as brain stimulation could play an important role. The early results of studies using repetitive transcranial magnetic stimulation (rTMS) suggest that stimulations delivered to the dorsolateral prefrontal cortex signiﬁcantly reduce cravings and improve decision-making processes in various addictive disorders. We therefore hypothesize that rTMS could lead to a decrease in alcohol consumption in patients with AUD.Methods/design: We report the protocol of a randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the efficacy of rTMS on alcohol reduction in individuals diagnosed with AUD. The study will be conducted in 2 centers in France. Altogether, 144 subjects older than 18 years and diagnosed with AUD will be randomized to receive 5 consecutive twice-daily sessions of either active or sham rTMS (10 Hz over the right DLPFC, 2000 pulses per day). The main outcomes of the study will be changes in alcohol consumption within the 4 weeks after the rTMS sessions. Secondary outcome measures will include changes in alcohol consumption within the 24 weeks, alcohol cravings, clinical and biological improvements, effects on mood and quality of life, as well as cognitive and safety assessments, and, for smokers, an assessment of the effects of rTMS on tobacco consumption.Discussion: Several studies have observed a beneficial effect of rTMS on substance use disorders by reducing craving, impulsivity and risk-taking behavior, and suggest that rTMS may be a promising treatment in addiction. However, to date, no studies have included sufficiently large samples and sufficient follow-up to confirm this hypothesis. The results from this large randomized controlled trial will give a better overview of the therapeutic potential of rTMS in AUD. Trial registrationClinicalTrials.gov, NCT04773691, registered February 26 2021https://clinicaltrials.gov/ct2/show/NCT04773691?term=trojak&draw=2&rank=5
The Efficacy of Famotidine in improvement of outcomes in Hospitalized COVID-19 Patients: A phase III randomised clinical trial
Authors: Samimagham Hamid Reza , Azad Mehdi Hassani , Haddad Maryam , Arabi Mohsen , Hooshyar Dariush , KazemiJahromi Mitra
Published: April 2021

IntroductionAs the first randomized clinical trial, this study evaluated the effect of Famotidine on the improvement of outcomes of hospitalized patients with COVID-19.MethodThis phase III randomized clinical trial was designed with two parallel arms, placebo-controlled, single-blind, and concealed allocation, and recruited 20 patients. Oral Famotidine 160 mg four times a day was given to patients until the discharge day or for a maximum of 14 days. Patients’ temperature, respiration rate, oxygen saturation, lung infiltration, lactate dehydrogenase (LDH) level and complete blood count (CBC) were measured at the baseline (before the intervention) and on day 14 after the intervention or on discharge day. Length of stay in the hospital and length of stay in the ICU were also measured as secondary outcomes of the study.ResultsThe results showed a significant decrease in LDH (P = 0.01), mean WBC (P = 0.04) and length of stay (P = 0.04) of patients with COVID-19 in the group treated with Famotidine compared to the control group. There was also a significant increase in oxygen saturation (P = 0.01) in the group treated with Famotidine compared to the control group. Cough improvement was also higher in the oral Famotidine group compared to the control group (P = 0.02).ConclusionThis was the first clinical trial on the effect of Famotidine on the improvement of hospitalized COVID-19 patients, which indicated that high-dose Famotidine improves patients’ clinical signs and reduces the severity of the disease and duration of hospitalization.
Holographic Transmitarray Antenna with linear Polarization in X band
Authors: Salehi Mahdi , Oraizi Homayoon
Published: April 2021

In this paper, we present the design and demonstration of transmitarray antennas (TAs) based on the holographic technique for the first time. According to the holographic theory, the amplitudes and phases of electromagnetic waves can be recorded on a surface, and then they can be reconstructed independently. This concept is used to design single-beam and multi-beam linearly polarized holographic TAs without using any iterative optimization algorithms. Initially, a transmission impedance surface is analyzed and compared with the reflection one. Then, interferograms associated with the scalar admittance distribution are defined according to the number and direction of the radiation beams. After that, a transmission metasurface of dimensions equal to 0.26λ0 is hired to design holographic TAs at 12 GHz. Several examples are provided to support the method. In the end, a linearly polarized circular aperture wideband holographic transmitarray antenna with a radius of 13.3 cm has been manufactured and tested. The antenna achieves 12.5% (11.4-12.9 GHz) 1-dB gain bandwidth and 23.8 dB maximum gain, leading to 21.46% aperture efficiency.
PMT-Gesetz: Wichtige Bestimmungen sind weder verfassungs- noch EMRK-konform
Authors: Mohler Markus
Published: April 2021

In einem ersten Beitrag wurde festgestellt, dass dem Bund für den Erlass der BWIS-Novelle im Rahmen des PMT-Gesetzes die verfassungsmässige Gesetzgebungskompetenz fehlt. In diesem Beitrag wird dargelegt, dass die Umschreibung «terroristische Aktivität» und damit «terroristischer Gefährder» nach Art. 23e BWIS in Bezug auf die Normbestimmtheit weder der Bundesverfassung noch der EMRK entspricht und mit anderen völkerrechtlichen Definitionen ebenso wenig übereinstimmt. Die Rechtsstaatlichkeitsanforderungen für grundrechtsbeschränkende Eingriffe werden nicht erfüllt.
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Dans une première contribution il a été constaté que la compétence législative constitutionnelle échappe à la Confédération pour promulguer la modification de la LMSI dans le cadre de la loi sur le MPT. Il sera démontré ci-après que les définitions de « l’activité terroriste » et celle de « terroriste potentiel » selon l’art. 23e LMSI ne correspondent ni à la définition de la Constitution fédérale ni à celle de la CEDH et qu’elles ne sont pas davantage conformes aux autres définitions du droit international. Les exigences relatives à l’État de droit, nécessaires pour autoriser les interventions qui restreignent les droits fondamentaux, ne sont pas remplies.
EFFICIENCY OF THE STATE POLICY AGAINST TINIZATION ECONOMICS: QUANTITATIVE AND QUALITATIVE COMPONENT
Authors: Zhylinska O. , Boiko A.
Published: April 2021

SUMMARY The article is devoted to the study of the formation and implementation of state policy to prevent shadow financial transactions. The shadow sector of the economy is identified as one of the main threats to the country's economic security and macroeconomic stability, a prerequisite for reducing the level of its investment attractiveness and competitiveness. The article has analyzed the effectiveness of the state policy of the de-shadowing of the national economy in terms of its regulatory, institutional, and economic components. The peculiarities of constructing the legal component of the state policy of counteracting the shadowing of the economy are considered. Its advantages and disadvantages are determined. Based on the study, it has concluded the low level of compliance of the modern system with the realities of economic development and the requirements of the international community, a significant variety of regulations, and their contradictory nature. The effectiveness of the institutional component was analyzed using quantitative (number of administrative proceedings for shadow financial transactions, sentences, etc.) and qualitative (the ratio between the amount of voluntarily paid and imposed on offenders fine, between the amount of reimbursed and established pecuniary damage, duration cases by the judiciary) indicators. Within the framework of economic indicators of efficiency of construction of policy of de-shadowing of the economy the cost of registration of documents at export/import, passing of control at export/import, level of the tax burden, etc. is considered. It is concluded that the excessive level of the tax burden on economic entities and the complexity of business procedures in Ukraine. A comparative analysis of the level of the shadow economy by the electric, monetary, the method of consumption of the population-retail trade, the method of unprofitable enterprises has determined. The expediency of improving the existing policy of counteracting shadow financial transactions by developing instruments for direct and indirect influence on the economic entities' behavior is substantiated.
METHODOLOGICAL FUNDAMENTALS OF INVESTMENT EVALUATION ATTRACTIVENESS OF THE CITY RECREATIONAL COMPLEX AGGLOMERATION
Authors: Opanasiuk Yu.
Published: April 2021

The article is devoted to the concept of " investment appeal". The evaluation of attractiveness of recreational facilities in urban areas for investors is considered. The author gives an author's interpretation of the investment appeal of the recreational sector. The investment appeal of the recreational sector is an integral characteristic of the individual objects of recreation and market infrastructure, conditions of activity and risks, which will lead to the achievement of the goals of the investor. The basic methods of estimation of investment appeal are considered in the article. The author concluded that none of them adapted to measure the investment appeal of the recreational areas. In the article the method of evaluating the attractiveness agglomerations for investors by analyzing recreation facilities. The author proposes to evaluate on five general indicators: the level of economic development of the agglomeration, level of investment infrastructure agglomeration, demographic characteristics of agglomeration, level of recreational infrastructure agglomeration, the level of criminogenic, environmental and other risks. Аuthor proposed general indicators calculated on the basis of standardized individual indicators. The algorithm of such evaluation is developed in the article. In the article the analysis of Sumy, Kharkiv, Kyiv, Lviv and Odessa agglomeration was carried out. The author identifies the main factors of attracting investors to agglomerations. Odessa agglomeration has positive factors for the investor: natural resource potential, large tourist flow, the large number of recreational facilities, highly developed financial infrastructure and transport systems, the level of overall agglomeration development. Monitoring the rating of investment will identify factors that impede the development of recreation. It helps us to propose measures increase the investment appeal of the recreational areas. It also allows us to develop programs for socio-economic development of urban agglomerations. Such evaluation may be performed by analysis of the implementation recreational development programs effectiveness.
Dextran Sulfate/Pramlintide Polyelectrolyte Nanoparticles as a Promising Delivery System: Optimization, Evaluation of Supramolecular Interactions and Effect on Conformational Stability of the Peptide Drug
Authors: Zuglianello Carine , Chamorro Andrés , de Oliveira Vanessa , Xavier Jr. Francisco , Lemos-Senna Elenara
Published: April 2021

In this study, we investigated the feasibility to obtain nanoparticles (NPs) by assembling pramlintide (Pram) with dextran sulfate (DexS), as a new approach for mucosal peptide delivery. DexS/Pram NPs were prepared by dropwise addition of a Pram solution to a DexS solution under magnetic stirring. The physicochemical characteristics of NPs and molecular interactions involved in the co-assembling were evaluated by dynamic light scattering (DLS), transmission electronic microscopy (TEM), isothermal titration microcalorimetry, Fourier-transform infrared spectroscopy (FTIR), fluorescence quenching, and circular dichroism (CD). DexS/Pram NPs displayed a narrow size distribution (ca. 200 nm), negative zeta potential (ca. −40 mV), association efficiency close to 100%, and nanogel behavior. The assembling with DexS increased the Pram α-helical content, stabilizing the peptide in its bioactive form. The colloidal stability of nanoparticles was dependent on the salt concentration and it could be assumed that peptide release from nanoparticles occurs by dissociation of the complex at physiological conditions.
Comparison of the SARS-CoV-2-inactivating activities of the differently manufactured hypochlorous acid water products with various pH
Authors: Takeda Yohei , Matsuda Sachiko , Jamsransuren Dulamjav , Ogawa Haruko
Published: April 2021

The use of effective disinfectants is a key method of controlling the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Hypochlorous acid water (HAW) has a broad spectrum of virucidal activities. We previously reported that acidic electrolyzed water, one of the HAW products, had potent SARS-CoV-2-inactivating activity and showed promise as a disinfectant. However, different manufacturing methods have produced several HAW products with various pH values. Here, we compared the SARS-CoV-2-inactivating activities of various HAW products. At sufficiently high volume and residual chlorine concentration (RCC), the HAW products inactivated SARS-CoV-2 efficiently regardless of pH or manufacturing method. However, although HAW products at pH 5.0–6.4 maintained high RCC and sustained virucidal activity for 21 days, the RCC rapidly decreased in HAW products at pH ≤ 3.0. Our results may guide in choosing appropriate HAW products for different usage situations.
Efeito do extrato pirolenhoso no desenvolvimento inicial de plantas de milho e feijão
Authors: Weber da Silva Darlan , Canepelle Eduardo , Carlson Writzl Thaniel , Daniel Steffler Andersson , Eduardo Schmitt Stein Jackson , Guerra Divanilde , Maisa da Silva Danni , Redin Marciel
Published: April 2021

O objetivo do trabalho foi avaliar a influência de diferentes concentrações de extrato pirolenhoso (EP) aplicado nas sementes e no solo sobre o desenvolvimento inicial de plantas de milho (Zea mays L.) e feijão preto (Phaseolus vulgaris L.). O experimento foi conduzido em vasos plásticos de 8 dm3 com as culturas do milho e feijão com aplicação do EP de duas formas, no solo e na semente. As concentrações de EP (água + EP) testadas no solo foram: 0; 0,5; 1,0; 1,5 e 2% v.v-1 e nas sementes: 0, 25, 50, 75 e 100% v.v-1. Foi determinado o índice de velocidade de emergência das plantas (VE) e avaliações morfológicas: altura de planta e diâmetro do colmo em avaliações quinzenais. Ainda, a determinação da matéria seca da parte aérea (MSPA) e raízes (MSR) foi realizada no final do experimento aos 60 dias após semeadura. O EP aplicado nas sementes de milho reduziu o diâmetro do colmo, altura de plantas e IVE, no feijão inibiu a germinação das sementes. Já quando aplicado no solo na concentração de 2,0% proporcionou aumento na altura das plantas de milho em 12 cm e incrementos na produção de MSR em 34,3%; no feijão reduziu o IVE, não promoveu incrementos na altura das plantas e MSR. Assim, o uso de EP aplicado no solo apresenta-se como um potencial insumo alternativo para o incremento no crescimento inicial de plantas de milho.
A FENOMENOLOGIA E O DISCURSO SOBRE AS CIÊNCIAS: UMA ANÁLISE COMPARATIVA ENTRE EDMUND HUSSERL E BOAVENTURA
Authors: Dantas Vieira Demóstenes
Published: April 2021

Este trabalho, de cunho bibliográfico e comparativo, propõe uma análise acerca de duas obras fundamentais no campo da Epistemologia/Filosofia da ciência: A Crise das Ciências Europeias: e a fenomenologia transcendental (1984), do filósofo Edmund Husserl e, Um Discurso Sobre as Ciências (2006), do sociólogo Boaventura de Souza Santos. Quanto à metodologia, este trabalho está dividido em duas partes. Na primeira, analisa-se a obra de Husserl (1984) e sua contribuição acerca da crise das ciências europeias e da fenomenologia como alternativa epistemológica. Na segunda, propõe-se uma discussão sobre o paradigma científico dominante e sobre o paradigma científico emergente propostos por Boaventura (2006). Os resultados apontam para deslocamentos teórico-metodológicos nas bases conceituais advindas do modelo de ciência positiva que predominou tanto nas Ciências Naturais/Exatas como no início das Ciências Sociais/Humanas. Por conseguinte, a fenomenologia apresenta-se como uma possibilidade epistemológica de (re) invenção da ciência moderna, subsidiando a construção de um novo modelo científico.
Genomic Instability in Cancer: Molecular Mechanisms and Therapeutic Potentials
Authors: Salmaninejad Arash , Ilkhani Khandan , Marzban Havva , Navashenaq Jamshid G. , Rahimirad Samira , Radnia Fatemeh , Yousefi Meysam , Bahmanpour Zahra , Azhdari Sara , Sahebkar Amirhossein
Published: April 2021

DNA damage usually happens in all cell types, which may originate from endogenous sources (i.e.,
DNA replication errors) or be emanated from radiations or chemicals. These damages range from changes in
few nucleotides to significant structural abnormalities on chromosomes and, if not repaired, could disturb the
cellular homeostasis or cause cell death. As the most significant response to DNA damage, DNA repair provides
biological pathways by which DNA damages are corrected and returned into their natural circumstance.
However, an aberration in the DNA repair mechanisms may result in genomic and chromosomal instability and
the accumulation of mutations. The activation of oncogenes and/or inactivation of tumor suppressor genes is a
serious consequence of genomic and chromosomal instability and may bring the cells into a cancerous phenotype.
Therefore, genomic and chromosomal instability is usually considered a crucial factor in carcinogenesis
and an important hallmark of various human malignancies. In the present study, we review our current understanding
of the most updated mechanisms underlying genomic instability in cancer and discuss the potential
promises of these mechanisms in finding new targets for the treatment of cancer.
In-silico Studies and Wet-Lab Validation of Camptothecin Derivatives for Anti-Cancer Activity Against Liver (HepG2) and Lung (A549) Cancer Cell Lines
Authors: Kalani Komal , Yadav Dharmendra K. , Alam Sarfaraz , Khan Feroz , Kashyap Mahendra P. , Srivastava Santosh K. , Pant Aditya B.
Published: April 2021

Bcakground:

In the present study, we have explored the utility of QSAR modelling, in
silico ADMET, docking, chemical semi-synthesis, and in vitro evaluation studies for the identification
of active camptothecin (CPT) derivatives against cancer-targeting human liver (HepG2) and
lung (A549) cancer cell lines.

Methods:

Two QSAR models were developed as screenings tools using the multiple linear regression
(MLR) method followed by ADMET and docking studies. The regression coefficient (r2) and
cross-validation regression coefficients (rCV2T) of the QSAR model for the HepG2 cell line was
0.95 and 0.90, respectively, and for the A549 cell line, it was 0.93 and 0.81, respectively.

Results:

In silico studies show that CPT derivatives (CPT-1 and CPT-6) possess drug-like properties.
Docking performed on DNA Topoisomerase-I showed significant binding affinity. Finally, predicted
active derivatives were chemically semi synthesized, spectroscopically characterized, and
evaluated in-vitro for cytotoxic/anticancer activity against HepG2 and A549 cell lines.

Conclusion:

The experimental results are consistent with the predicted results. These findings may
be of immense importance in the anticancer drug development from an inexpensive and widely
available natural product, camptothecin.
Depression: An Insight into Heterocyclic and Cyclic Hydrocarbon Compounds Inspired from Natural Sources
Authors: Shah Abdul Jalil , Mir Reyaz Hassan , Mohi-ud-din Roohi , Pottoo Faheem Hyder , Masoodi Mubashir Hussain , Bhat Zulfiqar Ali
Published: April 2021

Depression, a well-known mental disorder, has global prevalence, affecting nearly 17% of
the population. Due to various limitations of the currently available drugs, people have been adopting
traditional herbal medicines to alleviate the symptoms of depression. It is notable to mention that natural
products, their derivatives, and their analogs are the main sources for new drug candidates of depression.
The mechanisms include interplay with γ-aminobutyric acid (GABA) receptors, serotonergic,
dopaminergic noradrenergic systems, and elevation of BDNF levels. The focus of this article is to review
the role of signalling molecules in depression and highlight the use of plant-derived natural compounds
to counter CNS depression.
Outcome of a HIV Positive Patient Infected with COVID-19 After an Autologous Bone Marrow Transplantation: A Case Report
Authors: Mardani Masoud , Sharifi-Razavi Athena , Sheibani Shirin , Baziboroun Mana
Published: April 2021

Background:

The World Health Organization (WHO) announced the SARS-COV-2 disease
pandemic on March 9, 2020. With the advent of this disease, another health burden was added
to about 37.9 million people in the world who are infected with HIV and are suffering from various
diseases. These people may be at serious risk of COVID-19. Information about the effects of
COVID-19 on people living with HIV, is limited.

Case Presentation:

We reported a 61-year-old man who was a known case of HIV from 6 years
ago that was being treated with HAART (highly active antiretroviral therapy). He also had a history
of Hodgkin’s lymphoma from 4 years ago who underwent autologous bone marrow transplantation
(BMT) 2 weeks before given referral to our hospital. He complained of weakness, anorexia,
and fever. RT-PCR for SARS-COV-2-RNA was positive in his nasopharyngeal and oropharyngeal
swab. He was diagnosed with COVID-19 infection and treated with atazanavir. After one week,
the patient discharged in a good general state.

Conclusion:

To the best of our knowledge, it is the first report of COVID-19 infection in an HIV
positive patient after BMT in Iran. Despite his immunodeficiency, COVID-19 disease had mild
manifestations and he had a good prognosis. We hope that our report and that of others can remain
promising to doctors and HIV patients cross fingers for COVID-19 recovery.
Novel Drug Delivery System of Phytopharmaceuticals: A Review
Authors: Aroraa Sumit , Dhoke Veerendra , Moharir Keshav , Yende Subhash , Shah Sapan
Published: April 2021

:

Herbal extracts and isolated bioactives from plants have proven their therapeutic activities,
as evidenced by preclinical and clinical research. However, there seems some disconnect in
their clinical utility as marked by a lack of proper delivery mechanism at desired sites of action.
This glitch nowadays is a task for global research activity and being addressed in novel drug delivery
systems. Steady progress is observed in integrating novel techniques of drug delivery with successful
incorporation of phytochemicals marked by scores of advantages. Limitations of conventional
drug delivery systems have overcome to a considerable extent by innovative drug delivery
methods which show improvement in targeted drug delivery, drug distribution, protection of active
substance, prolonged action, and stability. The perspective of this review thus focuses on the
progress in novel drug delivery systems with a spotlight on nanocarriers for active herbal agents,
their preparation methods with types, examples of active ingredients incorporated, and biomedical
applications.
Specific learning difficulty: autism, dyscalculia, dyslexia and dysgraphia
Authors: Intriago Karina Eliana Castro , Rodríguez Liliana Magdalena Alcívar , Cevallos Luis Alfredo Tubay
Published: April 2021

There are specific learning difficulties such as autism, dyscalculia, dyslexia and dysgraphia, the purpose of this article is to understand how these disorders affect verbal, non-verbal, logical and written communication in the social relationships of children who suffer from it. The qualitative methodology was applied in combination with the desk review technique, obtaining clear and pertinent criteria, an analysis of concepts was proposed on each of their meanings, characteristics and typology, suggestions of learning techniques are presented regarding the way correct to reduce disorders, the opinion of different authors who have carried out studies on the subject was obtained, interpreting from the pedagogical perspective and the importance of knowing the subject to act against these learning problems.
importância da governação integrada do oceano para uma Economia azul em Angola
Authors: Ginga Damiao
Published: April 2021

A visão apresentada no presente artigo científico tem o principal objetivo de fomentar a consciência no seio dos principais decisores políticos, económicos e acadêmicos, de que Angola necessita de uma nova abordagem à governança dos assuntos do mar, especialmente devido ao atual contexto de recessão da economia nacional, onde o pensamento político da governação do mar pode alterar o modo totalmente displicente de exercer o poder e de explorar os recursos do oceano. Esta abordagem foi possível, através de uma revisão bibliográfica e documental, adotando uma abordagem qualitativa, mediante um raciocínio dedutivo. Portanto, Angola, à semelhança de outros Estados costeiros, precisa de assumir uma gestão e exploração integrada e tridimensional dos assuntos do mar, como um desígnio estratégico nacional, onde a edificação de uma Economia do mar, clusterizada, representará o núcleo duro de uma governaça integrada dos espaços marítimos em Angola.
PERKEMBANGAN MORAL SISWA SEKOLAH DASAR BERDASARKAN TEORI KOHLBERG
Authors: Hasanah Enung
Published: April 2021

Teori Kohlberg dikenal sebagai teori yang mengukur tingkatan moral seseorang. Penelitian bertujuan untuk mengukur tingkat perkembangan moral siswa SD yang berusia antara 11-12 tahun, berdasarkan tahapan perkembangan teori Kohlberg. Penelitian menggunakan metode penelitian kualitatif. Hasil penelitian menunjukan bahwa anak-anak SD yang berusia 11-12 tahun secara umum termasuk dalam tahap pra konvensional tahap ½ yang dominan diikuti tahap 2 dan 2/3, yang cenderung  melakukan sesuatu kegiatan bukan karena membutuhkan hasil melainkan karena takut dihukum.
Role of education towards environmental management: Case study Goma Junior High School DR Congo
Authors: Dechy Bernard , Chinyhabuuma Mwisha
Published: April 2021

Research aims to understand the rule of education in Goma Junior High School, to understand the level of environmental management, and relationship between education and environmental management. This research employed a mixed method which is quantitate and qualitative. Technique to gather non-numerical data, the researcher utilized a qualitative data collection approach. The results show that environmental education helps students improve their living, study through tree planting, waste management, good environmental management in the school farm and increase number of environmental management ambassadors in the community. The students have a moderate level of understanding on environmental issues and concerns while the rest of the students either have very good or good in understanding environmental management issues. Moreover, students are at the knowledge and understanding A to A continuum level while the list is in the problem-solving skills level of the A to A continuum phase. Students become more responsible in matters dealing with environmental management such as planting tree, keeping their living environment clean and attractive, and managing waste well. Peranan pendidikan terhadap menejemen lingkungan: Studi kasus Goma Junior High School DR Congo Penelitian ini bertujuan untuk mengetahui bagaimanakah aturan pendidikan di Sekolah Menengah Pertama Goma, untuk memahami sistem pengelolaan lingkungan, dan memahami hubungan antara pendidikan dan pengelolaan lingkungan di Sekolah Menengah Pertama Goma, DR Congo. Penelitian ini menggunakan metode campuran yaitu kuantitatif dan kualitatif. Pengumpulan data nonnumerik menggunakan pendekatan pengumpulan data kualitatif. Hasil penelitian menunjukkan bahwa pendidikan lingkungan membantu siswa meningkatkan taraf hidup, belajar melalui penanaman pohon, pengelolaan sampah, pengelolaan lingkungan yang baik di sekolah pertanian dan meningkatkan jumlah duta pengelolaan lingkungan di masyarakat. Sebagian besar siswa memiliki tingkat pemahaman yang moderat tentang masalah dan masalah lingkungan, sedangkan siswa lainnya memiliki pemahaman yang sangat baik atau baik dalam masalah pengelolaan lingkungan. Siswa berada pada pengetahuan dan pemahaman tingkat kontinum A ke A sedangkan daftar berada pada tingkat keterampilan pemecahan masalah dari tahap kontinum A ke A. Mahasiswa menjadi lebih bertanggung jawab dalam hal-hal yang berhubungan dengan pengelolaan lingkungan seperti penanaman pohon, menjaga lingkungan hidup tetap bersih dan menarik, serta mengelola sampah dengan baik.
Pengaruh Penggunaan LMS dan Aplikasi Telegram terhadap Aktivitas Belajar
Authors: Widiyono Aan
Published: April 2021

Penelitian ini bertujuan untuk mendeskripsikan pengaruh penggunaan LMS dan aplikasi Telegram terhadap aktivitas belajar mahasiswa. Metode penelitian ini menggunakan pendekatan kuantitatif. Sampel dalam penelitian ini adalah mahasiswa PGSD 3A3 UNISNU Jepara pada Mata Kuliah Teknologi Pendidikan yang berjumlah 28 mahasiswa. Instrumen pengumpulan data menggunakan angket dengan skala Likert pada penggunaan LMS, aplikasi telegram, dan aktivitas belajar yang telah diuji validitas dan reliabilitas sebelumnya. Teknik analisis data menggunakan regresi linier berganda. Hasil analisis data menunjukkan bahwa penggunaan LMS berpengaruh positif dan signifikan terhadap aktivitas belajar dengan signifikansi 0,000; Aplikasi Telegram berpengaruh positif dan signifikan terhadap aktivitas belajar dengan signifikansi 0,000, dan Penggunaan LMS dan aplikasi Telegram secara simultan berpengaruh signifikan terhadap aktivitas belajar sejumlah 90,1% dengan signifikansi 0,000. Penelitian ini dapat dijadikan acuan bahwa penggunaan kedua aplikasi tersebut dapat memberikan pengaruh terhadap aktivitas belajar. Sedangkan pada penggunaan LMS lebih memberikan pengaruh terhadap aktivitas belajar dibanding dengan penggunaan aplikasi Telegram. The Effect of Using LMS and Telegram on Students' Learning Activities This study aims to describe the effect of using LMS and Telegram applications on student learning activities. This research method uses a quantitative approach. The sample in this study were 28 students of PGSD 3A3 UNISNU Jepara in the Educational Technology course. The data collection instrument used a questionnaire with a Likert scale on the use of LMS, Telegram application, and learning activities that had been tested for validity and reliability before. The data analysis technique used multiple linear regression. The results of data analysis indicate that the use of LMS has a positive and significant effect on learning activities with a significance of 0.000; Telegram application has a positive and significant effect on learning activities with a significance of 0.000, and The use of LMS and Telegram application simultaneously have a significant effect on learning activities amounting to 90.1% with a significance of 0.000. This research can be used as a reference that the use of these two applications can influence learning activities. Whereas the use of LMS has more influence on learning activities than the use of the Telegram application
Ecologia Administrativa
Authors: De Magalhães Celso
Published: April 2021

Ecologia é a ciência que determina a influência do local sôbre os organismos que nêle se encontram. Todos sabem que o trigo, por exemplo, não dá em qualquer parte, como sabem que o elefante não vive em qualquer lugar. A planta e o animal, quando» mudam de habitat, sofrem transformações por vêzes muito grandes. Para qtie isso não suceda, e possam algumas espécies sobreviver, necessário se torna tratá-las de forma especial, que a Ecologia orienta.
Municipalismo e descentralização administrativa
Authors: Omegna Nelson
Published: April 2021

"Municipalismo e Descentralização Administrativa” é um trabalho que resume, com objetividade e clareza, alguns aspectos do Sistema Federativo em função das realidades, interesses e reivindicações dos Municípios — as Unidades Elementares componentes da Federação.
Особенности полиморфного превращения в титане
Authors: Спивак Л.В. , Щепина Н.Е.
Published: April 2021

Using differential scanning calorimetry, the regularities of polymorphic α↔β transformation in polycrystalline titanium WТ 1-00 were studied. The values of the activation energy of the α↔β transformation during heating of titanium (760±30 kJ/mol and 1100±100 kJ/mol) were determined, which were dependent on the thermal history of the metal. It is suggested that the recrystallization mechanisms during heating and cooling are controlled by diffusion-free and diffusion mechanisms implemented in overlapping temperature intervals.
Структурная поляризация в системе проводник--диэлектрик
Authors: Соцков В.А. , Ашхотов О.Г. , Ашхотова И.Б. , Магкоев Т.Т.
Published: April 2021

The properties of the paraffin-graphite composite are investigated. It is shown that the introduction of a conducting phase into the dielectric allows us to significantly modify the properties of the composite. The formation of dipoles depends on the concentration of the conducting phase and on the presence of an oxide shell that prevents the formation of chains (macrodipoles) of the conductor. The obtained giant values of the real part of the dielectric permittivity of the studied composite are explained by the structural polarization of the heterogeneous dielectric.
Health Natural Language Processing: Methodology Development and Applications
Authors: Hao Tianyong , Huang Zhengxing , Liang Likeng , Weng Heng , Tang Buzhou
Published: April 2021

With the rapid growth of information technology, the necessity for processing substantial amounts of health data using advanced information technologies is increasing. A large amount of valuable data exists in natural text such as diagnosis text, discharge summaries, online health discussions, and eligibility criteria of clinical trials. Health natural language processing, as an interdisciplinary field of natural language processing and health care, plays a substantial role in a wide scope of both methodology development and applications. This editorial shares the most recent methodology innovations of health natural language processing and applications in the medical domain published in this JMIR Medical Informatics special theme issue entitled "Health Natural Language Processing: Methodology Development and Applications".
A Biomedical Knowledge Graph System to Propose Mechanistic Hypotheses for Real-World Environmental Health Observations: Cohort Study and Informatics Application
Authors: Fecho Karamarie , Bizon Chris , Miller Frederick , Schurman Shepherd , Schmitt Charles , Xue William , Morton Kenneth , Wang Patrick , Tropsha Alexander
Published: April 2021

Background

Knowledge graphs are a common form of knowledge representation in biomedicine and many other fields. We developed an open biomedical knowledge graph–based system termed Reasoning Over Biomedical Objects linked in Knowledge Oriented Pathways (ROBOKOP). ROBOKOP consists of both a front-end user interface and a back-end knowledge graph. The ROBOKOP user interface allows users to posit questions and explore answer subgraphs. Users can also posit questions through direct Cypher query of the underlying knowledge graph, which currently contains roughly 6 million nodes or biomedical entities and 140 million edges or predicates describing the relationship between nodes, drawn from over 30 curated data sources.

Objective

We aimed to apply ROBOKOP to survey data on workplace exposures and immune-mediated diseases from the Environmental Polymorphisms Registry (EPR) within the National Institute of Environmental Health Sciences.

Methods

We analyzed EPR survey data and identified 45 associations between workplace chemical exposures and immune-mediated diseases, as self-reported by study participants (n= 4574), with 20 associations significant at P<.05 after false discovery rate correction. We then used ROBOKOP to (1) validate the associations by determining whether plausible connections exist within the ROBOKOP knowledge graph and (2) propose biological mechanisms that might explain them and serve as hypotheses for subsequent testing. We highlight the following three exemplar associations: carbon monoxide-multiple sclerosis, ammonia-asthma, and isopropanol-allergic disease.

Results

ROBOKOP successfully returned answer sets for three queries that were posed in the context of the driving examples. The answer sets included potential intermediary genes, as well as supporting evidence that might explain the observed associations.

Conclusions

We demonstrate real-world application of ROBOKOP to generate mechanistic hypotheses for associations between workplace chemical exposures and immune-mediated diseases. We expect that ROBOKOP will find broad application across many biomedical fields and other scientific disciplines due to its generalizability, speed to discovery and generation of mechanistic hypotheses, and open nature.
Effectiveness and Utility of Virtual Reality Simulation as an Educational Tool for Safe Performance of COVID-19 Diagnostics: Prospective, Randomized Pilot Trial (Preprint)
Authors: Birrenbach Tanja , Zbinden Josua , Papagiannakis George , Exadaktylos Aristomenis K , Müller Martin , Hautz Wolf E , Sauter Thomas Christian
Published: April 2021

BACKGROUND

Although the proper use of hygiene and personal protective equipment (PPE) is paramount for preventing the spread of diseases such as COVID-19, health care personnel have been shown to use incorrect techniques for donning/doffing of PPE and hand hygiene, leading to a large number of infections among health professionals. Education and training are difficult owing to the social distancing restrictions in place, shortages of PPE and testing material, and lack of evidence on optimal training. Virtual reality (VR) simulation can offer a multisensory, 3-D, fully immersive, and safe training opportunity that addresses these obstacles.

OBJECTIVE

The aim of this study is to explore the short- and long-term effectiveness of a fully immersive VR simulation versus a traditional learning method regarding a COVID-19–related skill set and media-specific variables influencing training outcomes.

METHODS

This was a prospective, randomized controlled pilot study on medical students (N=29; intervention VR training, n=15, vs control video-based instruction, n=14) to compare the performance of hand disinfection, nasopharyngeal swab taking, and donning/doffing of PPE before and after training and 1 month later as well as variables of media use.

RESULTS

Both groups performed significantly better after training, with the effect sustained over one month. After training, the VR group performed significantly better in taking a nasopharyngeal swab, scoring a median of 14 out of 17 points (IQR 13-15) versus 12 out of 17 points (IQR 11-14) in the control group, P=.03. With good immersion and tolerability of the VR simulation, satisfaction was significantly higher in the VR group compared to the control group (median score of User Satisfaction Evaluation Questionnaire 27/30, IQR 23-28, vs 22/30, IQR 20-24, in the control group; P=.01).

CONCLUSIONS

VR simulation was at least as effective as traditional learning methods in training medical students while providing benefits regarding user satisfaction. These results add to the growing body of evidence that VR is a useful tool for acquiring simple and complex clinical skills.
İKTİSADİ VE İDARİ BİLİMLER FAKÜLTESİ ÖĞRENCİLERİNİN MUHASEBE EĞİTİMİNE KARŞI TUTUMLARININ COVID-19 PANDEMİ DÖNEMİNDE İNCELENMESİ
Authors: YARDIMCIOĞLU Mahmut , ŞITAK Başak , ŞITAK Petek
Published: April 2021

Amaç: Bu çalışmanın amacı, Çankırı Karatekin Üniversitesi İktisadi ve İdari Bilimler Fakültesinde muhasebe dersi alan öğrencilerin muhasebe eğitimine karşı tutumlarının tespit edilmesidir. Çalışmanın bir diğer amacı ise öğrencilerin muhasebe eğitimine karşı tutumlarının demografik özellikler ile ilişkisini ölçmektir. Yöntem: Araştırmanın evrenini Çankırı Karatekin Üniversitesi İktisadi ve İdari Bilimler Fakültesinde muhasebe dersi alan öğrenciler oluşturmaktadır. Araştırma, COVID-19 pandemisinin yaygın olarak görüldüğü 01.05.2020 ile 01.10.2020 tarihleri arasında 330 öğrenci ile birlikte gerçekleştirilmiştir. Çalışmada veri toplama aracı olarak anket formu kullanılmış, çevrimiçi anket ile öğrencilere ulaşılmıştır. Verilerin analizi için SPSS v.22 paket programı kullanılarak; Frekans, T Testi, One Way Anova analizi ile veri çözümlemeleri yapılmıştır. Bulgular: Araştırmanın amacı doğrultusunda yapılan analizler sonucunda öğrencilerin muhasebe eğitimine karşı tutumlarının cinsiyet, yaş, gelir durumu ve akademik ortalama değişkenleri açısından farklılık gösterdiği tespit edilmiştir. Sonuç: Öğrencilerin muhasebe derslerini eğlenceli ve motive edici bulmadığı, muhasebe çalışırken kaygılı oldukları, rahat ve sakin olamadıkları belirlenmiştir. Ancak aynı zaman da muhasebeyi seçtikleri bölüm ve çalışma yaşamı için gerekli gördükleri, ileride sahip olmak istedikleri meslek için de önemli buldukları tespit edilmiştir.