bluuebunny/crossref_metadata_2025 huggingface dataset:
BIOAVAILABILITY ENHANCEMENT BY FLOATING MICROBALLOONS OF DIPYRIDAMOLE AND CLOPIDOGREL: IN VIVO PHARMACOKINETIC STUDY
Authors: KRISHNA SEELAM RAMYA , RAMU A. , VIDYADHARA S. , RANI A. PRAMEELA
Published: November 2021

Objective: In vivo pharmacokinetic studies of clopidogrel and dipyridamole floating microballoons to check their bioavailability enhancement.
Methods: The bioanalytical method development was carried by using HPLC with column Poroshell 120 EC-C 18; 4.6x100 mm. The in vivo pharmacokinetic studies were performed in Wistar male rats and the obtained data from the pharmacokinetic parameters were analyzed using PK Solver software.
Results: The developed bioanalytical method was found to be linear in the concentration range of 1-100 ng/ml for clopidogrel bisulfate and 0.02-4µg/ml for dipyridamole with correlation coefficient of 0.9993 and 0.9987 respectively. The study results showed that the method was simple, linear, accurate and precise. The in vivo studies indicated that the AUC was found to be increased by 33.3% and 154.5% for clopidogrel and dipyridamole micro balloons, respectively, when compared to their pure drugs.
Conclusion: The bioanalytical methods development and their validation parameters indicated that the methods are accurate, precise and linear in the studied range of concentrations. In vivo test results infer to the effective, sustained release of both the drugs when formulated as micro balloons and increase in the absorption, thereby enhancing the bioavailability of the drugs. The pharmacokinetic studies also confirmed the increase in the mean residence time of the drugs when formulated as floating microballoons.
A COMPREHENSIVE CHEMICAL CHARACTERIZATION OF IN SITU OPHTHALMIC GEL
Authors: KURNIAWANSYAH INSAN SUNAN , SOPYAN IYAN , RUSDIANA TAOFIK , PRAMASHELA FIRDA SILVIA , SUBARNAS ANAS
Published: November 2021

In situ ophthalmic gel is a gel preparation that is initially in the form of ophthalmic solution that dripped into the eye and then the solution turns into a gel after contact with the surface of the eye. In situ gel will undergo phase change to gel due to pH, electrolyte and temperature conditions. So that the preparation of ophthalmic in situ gel is required characterization to make sure that the prepared preparations meet the standards and are safe when used. Chemical evaluation includes pH, concentration, chemical bonds, crystallization and drug and polymer interactions. The purpose of this review is to discuss the evaluation methods used in preparations, and to see whether the pH of in situ ophthalmic gel formulation that provided can met the ideal pH requirements of the eye, so that the ophthalmic in situ gel preparation would not causing irritation and liquid tear production.
ACTIVITY SCREENING AND STRUCTURE MODIFICATION OF ARTOCARPIN AGAINST ACE2 AND MAIN PROTEASE THROUGH IN SILICO METHOD
Authors: FAUZI MUHAMMAD , FADILLAH ARIS , RAHMAN FAUZI , RAMADHANI JUWITA , ERLIANTI KARINA , HASNIAH  , SOEMARI YULISTIA BUDIANTI , MALIK ABDUL
Published: November 2021

Objective: SARS-CoV-2 is a type of coronavirus that causes COVID-19 disease. Currently, the right and effective drug for the treatment of COVID-19 has not been found. Artocarpin in the breadfruit plant (Artocarpus altilis), which was tested, has been shown to have antiviral activity. However, artocarpin has a hydroxyl group that can undergo oxidation within a certain time, thereby reducing the stability of the compound and non-specific antiviral activity.
Methods: In this study, the structural modification of artocarpin was carried out to obtain compounds with anticoronavirus activity with good physicochemical properties. This research was conducted in silico, including molecular docking simulation, bioavailability prediction, and preADMET.
Results: The top 20 modified compounds were selected from each target's top 3 compounds, which had better bond energies compared to the positive control. These 3 compounds have the potential to inhibit ACE2 and Mpro receptors and 1 compound are better at inhibiting both.
Conclusion: From the results of the research conducted, we conclude that the 3 best compounds can be potential candidates that can be developed as COVID-19 therapy.
FORMULATION AND IN VITRO–IN VIVO PHARMACOKINETIC EVALUATION OF CARDIOVASCULAR DRUG-LOADED PULSATILE DRUG DELIVERY SYSTEMS
Authors: PASUPULETI KUMAR BABU , A. VENKATACHALAM , KESAVAN BHASKAR REDDY
Published: November 2021

Objective: This study is to formulate Nebivolol into a Pulsatile liquid, solid composite compression coated tablet, which will delay the release of the drug in early morning hypertension conditions.
Methods: The liquid, solid composite tablet was formulated and compressed with the ethylcellulose coating polymer. The percent in vitro drug release of the liquid solid composite compressed tablet was tested. Based on disintegration time and wetting time, the LCS2, LCS3, LSC6, LCS7 and LCS12 formulations were found to be the optimized solid-liquid compacts fast-dissolving core tablet formulations, which may be excellent candidates for further coating with polymer to transfer into press coated pulsatile tablet formulations. Coating the core tablet with varying ethyl cellulose concentrations resulted in five different formulations of the pulsatile press-coated tablet (CT1, CT2, CT3, CT4, CT5). In vitro drug release, in vitro release, kinetic studies, in vivo pharmacokinetic and stability tests were all performed for the prepared pulsatile press coated tablet.
Results: CT3 tablets are coated with ethyl cellulose polymer, which shows maximum controlled drug release from the core tablet i.e. 96.34±1.2% at 8th h. It shows there was an efficient delay in drug release form core tablet i.e. up to 3 h, followed by the maximum amount of drug release of 96.34±2.4 at 8h. Which shows the core drug will be more efficiently protected from the gastric acid environment 1.2 pH, duodenal environment 4.0 pH and release drug only in the small intestine.
Conclusion: According to the findings, CT3 Pulsatile press-coated tablet increased the bioavailability of Nebivolol by 3.11 percent.
AN ASSESSMENT ON BUCCAL MUCOADHESIVE DRUG DELIVERY SYSTEM
Authors: LAKSHMI V. LEELA , M. S. UMASHANKAR , M. ALAGUSUNDARAM
Published: November 2021

Buccal drug delivery system (BDDS) has won a variety of exposure and traction as it possesses plenty of advantages and benefits as evaluate to different mucosal drug delivery systems. Buccal path for systemic drug delivery, the use of mucoadhesive polymers twill significantly increase the efficacy of many tablets, has been of outstanding interest over the previous couple of decades. This article affords a precise of BDDS mechanisms, consisting of a composition of the oral mucosa, delivery mechanism, numerous forms of BDDS, formulation, assessment and application of BDDS. Additionally, this text affords a precis over the patents, advertised products and destiny factors of BDDS. In this evaluation article, we've got tried to assemble the maximum significant reports (1988 to 2021) of formulation, assessment, application, patents of BDDS. This review will help pharmaceutical researchers to clarify the potential of BDDS to overcome the various existing drug delivery dispute like the efficiency of absorption, permeability and bioavailability of drugs.
STRUCTURE-BASED MULTITARGETED MOLECULAR DOCKING ANALYSIS OF PYRAZOLE-CONDENSED HETEROCYCLICS AGAINST LUNG CANCER
Authors: JAMES JAINEY P. , T. C. AISWARYA , PRIYA SNEH , JYOTHI DIVYA , R. DIXIT SHESHAGIRI
Published: November 2021

Objective: The significant drawbacks of chemotherapy are that it destroys healthy cells, resulting in adverse effects. Hence, there is a need to adopt new techniques to develop cancer-specific chemicals that target the molecular pathways in a non-toxic fashion. This study aims to screen pyrazole-condensed heterocyclics for their anticancer activities and analyse their enzyme inhibitory potentials EGFR, ALK, VEGFR and TNKS receptors.
Methods: The structures of the compounds were confirmed by IR, NMR and Mass spectral studies. The in silico techniques applied in this study were molecular docking and pharmacophore modeling to analyse the protein-ligand interactions, as they have a significant role in drug discovery. Drug-likeness properties were assessed by the Lipinski rule of five and ADMET properties. Anticancer activity was performed by in vitro MTT assay on lung cancer cell lines.
Results: The results confirm that all the synthesised pyrazole derivatives interacted well with the selected targets showing docking scores above-5 kcal/mol. Pyrazole 2e interacted well with all the four lung cancer targets with its stable binding mode and was found to be potent as per the in vitro reports, followed by compounds 3d and 2d. Pharmacophore modeling exposed the responsible features responsible for the anticancer action. ADMET properties reported that all the compounds were found to have properties within the standard limit. The activity spectra of the pyrazoles predicted that pyrazolopyridines (2a-2e) are more effective against specific receptors such as EGFR, ALK and Tankyrase.
Conclusion: Thus, this study suggests that the synthesised pyrazole derivatives can be further investigated to validate their enzyme inhibitory potentials by in vivo studies.
CURRENT MEASURES AGAINST OPHTHALMIC COMPLICATIONS OF DIABETES MELLITUS-A SHORT REVIEW
Authors: MANORMA  , MAZUMDER RUPA , RANI ANJNA , BUDHORI RAJAT , KAUSHIK AYUSHI
Published: November 2021

Diabetes mellitus (DM) is a metabolic disorder, whose prevalence is predicted to rise shortly. The present review focuses on the various ocular complications associated with DM, and the various ophthalmic formulation approaches developed to treat the same. Diabetic macular edema (DME), diabetic retinopathy, cataracts, and glaucoma are some of the major vision-threatening complications linked to DM. The ocular route of drug delivery has undergone several advancements in recent decades, the introduction of various novel drug delivery systems (DDS), various modifications in the existing formulation approaches, development of custom-designed personalized medications, being some of the major developments introduced in the field of ocular drug delivery. Due to the application of state-of-the-art technologies in the field of innovations related to ocular DDS, patients have been immensely benefited by the current modes of ocular treatment imparting fewer side effects, enhanced penetration, sustained drug effect, and so on. The present review includes and emphasizes the gradual development that has occurred from the conventional ophthalmic dosage forms to the currently reported novel ocular drug delivery approaches along with the related clinical research works.
EUDRAGIT COATED ALGINATE BEADS BEARING OXALIPLATIN LOADED LIPOSOMES: FORMULATION, OPTIMIZATION AND IN VITRO CHARACTERIZATION
Authors: TIWARI ANKITA , JAIN SANJAY K.
Published: November 2021

Objective: The present investigation aimed to develop and characterize Eudragit S-100 coated alginate beads bearing oxaliplatin loaded liposomes for colon-specific drug delivery.
Methods: Liposomes were formulated by the thin-film hydration method. The process and formulation variables were optimized by Box-Behnken design (BBD) with the help of Design-Expert® Software. Three independent variables taken were HSPC: Chol molar ratio (X1), hydration time (X2), and sonication time (X3). The response variables selected were entrapment efficiency of oxaliplatin, polydispersity index, and vesicle size.
Results: The liposomes possessed an average vesicle size of 110.1±2.8 nm, PDI 0.096±0.3, zeta potential of-6.70±1.4 mV, and entrapment efficiency of 27.65%. The beads were characterized for their size, in vitro drug release, and swelling index. The degree of swelling of the beads was found to be 2.3 fold higher at pH 7.4 than at pH 1.2. The in vitro drug release depicted a sustained drug release in 48 h.
Conclusion: The outcomes of the study proposed that the developed system can be effectively used for site-specific drug delivery to the colon via the oral route.
MODERATION EFFECT OF MORAL OBLIGATION ON STUDENT’S INTENTION TOWARDS ACADEMIC DISHONEST BEHAVIOUR: THE CASE OF PUBLIC UNIVERSITIES IN GHANA
Authors: DZAKADZIE YAYRA
Published: November 2021

The study examined the moderation effect of moral obligation on students’ intention towards academic dishonest behaviour. A survey-inferential design was used to randomly sample the views of 1,200 undergraduate university students. A structured questionnaire was used to collect. Structural Equation Modelling (SEM) and Conditional Process Analysis (CPA) were used for the analyses. Moral obligation statistically significantly moderated the intention to engage in academic dishonesty.  It was concluded that an intention to engage in academic dishonesty decrease as moral obligation increases in the individual students. It was recommended that university authorities should introduce moral education as a core course among undergraduate students. This would instill in them a higher moral obligation in order to curb the academic dishonesty menace.
KONSTANTA AMERIČKE SPOLJNE POLITIKE U PRINUDI NAD SRBIMA OD 1992. GODINE
Authors: Mirkov Zeljko
Published: November 2021

Konstanta američke spoljne politike koja se primećuje na tlu bivše Jugoslavije je prinuda nad Srbima. Svetska dominacija SAD našla je na tom prostoru pogodan poligon. SAD mogu pristrasno podržati koga žele protiv Srba koji su na svakom mestu, ma u kom položaju, osetili neprincipijelnost te spoljne politike. Gubitak za Srbe je dobitak SAD koji se tako odužuje svojim saveznicima u regionu. Hrvatskoj se podržala secesija i dozvoljeno etničko čišćenje Srba kojima je secesija Krajine uskraćena. U Bosni i Hercegovini su Srbi, iako autohtoni, smatrani agresorom. U Srbiji je Kosovo i Metohija, duhovni i istorijski izvor Srba, podržano za secesiju. Bombardovanje i pretnje su u regionu primenjivane samo prema Srbima. Od Klintona predsednici SAD pokazuju da nije bitno koliko je nešto protivpravno ili nepravedno. Prinuda je ostavila trajnu posledicu na prirodu američkog pristupa Balkanu.
EKSTREMIZAM I NOVA REALNOST: SVET U DOBA KORONAVIRUSA
Authors: Glisin Vanja
Published: November 2021

Prikaz knjige:
Đorić, Marija. 2021. Ekstremizam i nova realnost: Svet u doba koronavirusa. Beograd: Institut za političke studije, 200 str.
SPECIJALNI MEĐUNARODNI KRIVIČNI SUD ZA LIBAN – OD ORIGINALNE IDEJE DO NEUBEDLJIVE REALIZACIJE
Authors: Gujanicic Dusan
Published: November 2021

Tema našeg rada je nastanak, struktura i delovanje međunarodnog Specijalnog suda za Liban, kako glasi njegov zvaničan naziv, koji je nastao iz potrebe da se sudi atentatorima na libanskog predsednika vlade Rafika Haririja 14. februara 2005. godine. U društvu nemalog broja međunarodnih krivičnih sudova koji su intenzivno nastajali poslednje dve do tri decenije, ovaj sud usled niza svojih osobenosti – dovoljno je pomenuti primera radi njegov način nastanka, stvarnu nadležnostu, kao i mogućnost suđenja u odsustvu – zauzima jedno prilično specifično mesto. S obzirom da se radi o materiji međunarodnog krivičnog prava, jasno je da analiza mora obuhvatiti pristup karakterističan za obe pravne oblasti bez kojih se ne može u celini shvatiti fenomen međunarodnih krivičnih sudova, a u okviru te celine još preciznije mešovitih, ,,hibridnih“ ili ,,internacionalizovanih“ sudova kao svojevrsnog ,,trećeg puta“ između domaćeg i međunarodnog pravosuđa, kojima pripada i Specijalni sud za Liban. Nakon sprovedene analize, prvenstveno, mada ne i isključivo, normativnom metodom, posebnog mesta koje zauzima ovaj sud u društvu mnogih međunarodnih sudova, zaključuje se da je na osnovu veoma specifičnog, a hronološki posmatrano poslednjeg u nizu na međunarodnom planu, iskustva Specijalnog suda za Liban, gotovo nemoguće sa sigurnošću predvideti dalji razvoj institucionalnih tendencija, osobina i eventualne prakse međunarodnog krivičnog pravosuđa ad hoc tipa.
English Pedagogy for Student with Emotional and Behavioral Disorders In An Inclusive School
Authors: Hikmah Nurbatra Laela , Meidina Andhini Desty
Published: November 2021

Inclusive school is a public school that the student with special needs can be educated together with normal students. Expanding the potential that they have through the appropriate teaching strategies is crucial to implement, especially for the student with EBD. The student with EBD is a student that has aggressive behavior and substantial negative influence in the learning process. In accordance to that, the researcher wants to investigate (1) the teaching strategies used by the English teacher for the student with Emotional and Behavioral Disorders (EBD), (2) the implementation of teaching strategies used by the English teacher for the student with Emotional and Behavioral Disorders (EBD). Using qualitative method, the research involves one English teacher of SD Satu Atap Sumbersari 1 Malang Inclusive School. The instruments used were observation and interview. The current research revealed that there were three strategies used by the English teacher at SD Satu Atap Sumbersari 1 Malang Inclusive School. First, the teacher shows the interest towards students’ progress through communication to the student with EBD. Second, giving the student an understanding to have control for everything occurring in their life by giving the student with EBD punishment when break the rules. Third, conducting class activities relevant to students’ interest with alternative activities made by the English teacher.
Incidencia de la segregación escolar por nivel socioeconómico en el rendimiento académico: El caso de Uruguay
Authors: Murillo F. Javier , Graña Raquel
Published: November 2021

Esta investigación se plantea con un doble objetivo: busca, por un lado, determinar la incidencia de la segregación escolar sobre el rendimiento en matemática y en lectura de los estudiantes de Educación Primaria de Uruguay; y, por otro, determinar la incidencia de la segregación controlando el efecto de los pares. Para ello, se realiza una explotación de los microdatos de Aristas 2017 con Modelos Multinivel, estimando la relación entre el rendimiento en matemática y en lectura para tercero y sexto de educación primaria, con cuatro caracterizaciones de segregación escolar. Los resultados confirman que la segregación escolar por nivel socioeconómico incide de forma clara en el rendimiento académico de los estudiantes uruguayos de educación primaria. Sin embargo, controlando el efecto pares, los datos más complejos apuntan a que solo la segregación escolar de los estudiantes de mayor nivel socioeconómico incide en el rendimiento y lo hace de forma negativa. De esta forma se concluye que la segregación afecta negativamente a todos los estudiantes, con lo que urge tomar medidas claras de lucha contra la segregación.
Sobre la vuelta de Rodó a las aulas
Authors: San Román Gustavo
Published: November 2021

El estudio de la obra de José Enrique Rodó tiene un lugar arraigado en el mundo académico, pero es necesario también llevar su lectura al gran público; la mejor manera de lograrlo es mediante su reintegración a la educación básica en su país natal. Los apuntes que siguen quieren apoyar esa meta.
Meningoencefalocele Basal: Tratamento e complicações. Revisão de literatura
Authors: Oliveira Daniel Fonseca , Dezena Roberto Alexandre
Published: November 2021

Encefalocele é uma malformação que consiste em herniação de conteúdo intracraniano através de defeito ósseo da convexidade ou base do crânio. Este conteúdo pode conter tecido cerebral, estruturas neurovasculares, líquor e meninges cerebrais. Ocorre na forma congênita ou adquirida. O subgrupo meningoencefalocele basal é uma rara condição que pode se apresentar com crises epilépticas, fístula liquórica, meningite e massa nasal. O tratamento pode ser extracraniano ou intracraniano (microcirúrgico e/ou endoscópico).
Systematic review: Epilepsy in sturge weber syndrome
Authors: Galafassi Roberta Zambo , Galafassi Giovanna Zambo , Aguiar Paulo Henrique Pires de
Published: November 2021

Introduction: Sturge Weber syndrome (SWS) is a rare, non-hereditary, congenital developmental condition. Abnormal embryological development would be the cause of this disease. The intensity of this process and its extension to adjacent tissues are responsible for the variety of expressions of the syndrome. The main characteristics are the presence of a facial spot at birth, known as port wine, and alterations in the central nervous system, like seizures and mental retardation. Objective: o evaluate the available surgical treatments for SWS epilepsy. Methods: The PubMed and LILACS databases were used, using “treatment” as selection criteria. A total of 18 papers selected were organized in a table for statistical analysis. Results: The majority of studies concluded that both clinical and surgical treatments could be effective in the management of SWS epilepsy, although its effectiveness depends on the disease progression. Conclusion: Clinical and surgical methods should be considered in the treatment of SWS epilepsy. An unanswered question that still remains is whether suppression of seizures could prevent future neurological symptoms and cognitive decline.
Hematoma epidural da fossa posterior na infância. Relato de caso e revisão da literatura
Authors: Pereira Carlos Umberto , Santos Leticia Adriele dos , Rabelo Nicollas Nunes
Published: November 2021

O hematoma epidural (HE) em criança apresenta um potencial risco de vida. A causa mais comum é queda acidental seguida de acidente de trânsito. A fratura occipital pode ser associada a essa condição. Hidrocefalia e escore na ECG, na admissão, são fatores determinantes para o prognóstico. O tratamento, a priori, é cirúrgico. Contudo, casos selecionados podem cursar com tratamento conservador. O diagnóstico precoce e o tratamento adequado têm apresentado excelente resultado. O hematoma epidural da fossa posterior (HEFP) em crianças apresenta bom prognóstico quando diagnosticado precocemente e tratado adequadamente. O paciente aqui relatado evoluiu bem e sem déficits neurológicos após tratamento cirúrgico.
Impar ganglion block in patients with pelvic neuropathic pain: Three case Reports and surgical technique
Authors: Rodrigues Adriano de Medeiros Barbosa , Mussi Carolina Angeli Kalaf , Barth Gabriela Marengo , Teixeira Isadora Lazzaretto , Aguiar Paulo Henrique Pires de , Franceschini Paulo Roberto
Published: November 2021

Pelvic pain and coccydynia are discomfort and disabling symptoms for many patients. Assessment and treatment are individualized. Among several options available, the sacrococcygeal ganglion or impar (known as ganglion of Walther), a sensitive station of the pelvis, is one of the main therapeutic targets. Although knowledge about the nature and extent of the innervation pattern of this ganglion in the pelvic region has not been completely elucidated, neuromodulation techniques have been described as efficient treatment options for pelvic pain and coccydynia arising from acute and chronic conditions such as endometriosis, trauma, postsurgical interventions and also from idiopathic factors. The main techniques include chemical rhizotomy with steroids and anesthetics injections or radiofrequency (thermocoagulation). In this review, we report three cases, two with endometriosis and pelvic procedures and one with coccydynia from fracture, who underwent ganglion impar injection. At 6 months follow up, the VAS (Visual Analogue Scale) improvement achieved varied from 70-90%, demonstrating to be a safe, less invasive and efficient technique.
Plague Epidemic of 1770–1771 and the Tatar Sloboda in Moscow
Authors: Khayretdinov D. Z.
Published: November 2021

The article deals with the history of the Tatar Sloboda in Moscow at the end of the 18th century, when a small Tatar Muslim community of the second Russian capital experienced upheavals in connection with the plague epidemic of 1770–1771. As a result of the epidemic, the number of the community and of the Tatar households in Moscow has significantly decreased; the old cemetery behind the Kaluga Gate was taken from the Tatars. In addition, this group of the population, which developed as an ethnoconfessional one, lost its sacred center — a mosque in Ovchinnaya Sloboda on Tatarskaya Street. The scientific novelty of the article consists in the publication of archival documents from the repositories of Moscow, including the first published document from the Russian State Archive of Ancient Acts with the data of the census of the Tatar Sloboda in 1773.
Musa Bigeev’s Social-Political Activity and His Correspondence With Enver Paşa
Authors: Khayrutdinov A. G.
Published: November 2021

The paper is devoted to the description of Musa Bigeev’s social and political activity. The research deals with Musa Bigeev’s correspondence (1917–1923) with highly controversial Turkish politician Enver Paşa, which was unstudied earlier.
‘The Samaritan Hexameron’ as an Arab-Muslim Anthropological Manifesto: Reading of the first Chapters of Ṣadaqah al-Ḥakīm’s Commentary on Genesis
Authors: Nofal F. O.
Published: November 2021

The offered to the reader article analyzes the first chapters of monumental commentary by Ṣadaqah b. Munajjā al-Ḥakīm on Genesis (XIII c.). On the base of the conducted analysis of the Middle Age Arab-speaking theologian, philosopher and doctor, the author comes to the conclusion that Samaritan thought depends on the most important achievements of Muslim one — especially, on Mu‘talizi and peripatetic natural- philosophical and metaphysical theories that don’t become less of an issue until the decline of classical era of Arab culture. For the first time in the history of orientalism it is shown that the basic principles of anthropological theories by al- Hakim retroduce the conceptions by Mu‘tazili Mu‘ammar ibn ‘Abbād alSulamī, faylasuf al- Kindī and ‘the Main Sheikh’, Ibn Sīnā. Separately is observed the connection between the ‘Hexameron’ by Ṣadaqah and works by other Samaritan theologians: the author notices that some particular anthropological notes by the theologian made a basis for an unpublished commentary by Muslim ibn Murjān and Ibrāhīm al-‘Ayyah (XVIII c.) on ‘Grizim’s’ Pentateuch. The conclusion of the work is dedicated to the general eclectic character of early and late exegetic tradition of Samaritan who accepted Muslim study of God and human as the most important for them.
Review on Damir V. Mukhetdinov, “The Muslims of Russia Looking for Political Subjectivity” (in Russian), Moscow: Medina, 2021
Authors: Loginov A. V.
Published: November 2021

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2020 y la crisis de Brasil como crisis de nuestra América: hacia una defensa del estado de bienestar en América Latina y el Caribe, más allá del Estado nacional
Authors: Gomes David
Published: November 2021

Este artículo tiene por objetivo discutir la crisis actual en Brasil como una crisis de Latinoamérica y el Caribe. En ese sentido, traslada metodológicamente el debate desde la bibliografía predominante sobre las crisis democráticas hacia una teoría de la sociedad de tres niveles. En su primera parte, se presenta y desarrolla de forma sintética la idea de una teoría de la sociedad de tres niveles. En la secuencia, en la segunda parte son discutidos los elementos principales para la comprensión de la crisis brasileña contemporánea. Por fin, en las conclusiones es planteada la tesis de que la crisis de Brasil debe ser comprendida como una crisis de nuestra América y que, por lo tanto, la defensa del Estado de bienestar en Latinoamérica y el Caribe debe ser una defensa más allá del Estado nacional. Así, los resultados que se exponen indican la necesidad de una mayor aproximación entre los distintos países de América Latina y del Caribe como forma de garantizar una mejor protección a la democracia y al Estado de bienestar en la región.
Mediación transformativa: la vulnerabilidad como apertura a la transformación de las relaciones familiares
Authors: Montoya-Sanchez Miguel Ángel , Salinas-Arango Natalia Andrea , Puerta Lopera Isabel
Published: November 2021

Con el propósito de contribuir al avance de las elaboraciones conceptuales con respecto a la mediación transformativa en el ámbito familiar, ponemos a consideración de los lectores este escrito que introduce, a manera de novedad, el concepto de vulnerabilidad como cualidad propia de la condición humana y que, para el caso de la familia, ubicaría en condición desventajosa a algunos de sus integrantes. No obstante, queremos mostrar como resultado que, si se cumplen cabalmente los pilares de la revalorización y el reconocimiento del otro, en la línea de rebasar la visión individualista con la que se ha venido ejerciendo la negociación de los conflictos, podrían lograrse resultados que, además de preservar la unidad y la armonía de la familia, minimizarían el dolor, el sufrimiento y el daño en las situaciones de crisis. La investigación estuvo orientada con el método cualitativo mediante el estudio de caso múltiple y se utilizaron las técnicas de la observación, la entrevista y los encuentros de mediación. La mediación transformativa se presenta como la oportunidad para que cada parte en conflicto pueda tener una mejor comprensión de sí misma y de la otra y, por ende, facilite asumir decisiones que mejoren las relaciones de familia. Se concluye que una cosa es que el conflicto cualifique la relación que identifica a los miembros de una familia, y otra muy distinta, generalmente mal entendida, es la vulnerabilidad que los distingue como protagonistas en dicha relación.
La casación penal: de la nomofilaquia al control de legitimidad constitucional de las sentencias
Authors: Troncoso Mojica Jeofrey Alfonso
Published: November 2021

El presente trabajo aborda los antecedentes de la casación penal, sus componentes teleológicos y la reforma constitucional de 1991 en Colombia. Esto con el fin de proponer, desde un enfoque constitucional, un control efectivo de las sentencias de segunda instancia que permita superar la clásica función nomofiláctica extrapolada del otrora Estado liberal surgido de la Revolución francesa sin propiciar una tercera instancia. Para desarrollar el problema de investigación, se adelantó un riguroso estudio documental, al que se le aplicó un método descriptivo y analítico a partir de los antecedentes de la casación y su naturaleza jurídico-política, los fundamentos teleológicos del recurso y su relación con el ideal de justicia que propugna el actual Estado constitucional de derecho. El estudio muestra que la función nomofiláctica de la casación cede ante la tutela efectiva de los derechos fundamentales de las partes, la reparación de los agravios infligidos y la búsqueda de un orden democrático justo. Por consiguiente, en la nueva filosofía del Estado colombiano, la casación está llamada a controlar los equívocos e inequidades de los jueces más allá de las arraigadas concepciones dogmáticas del recurso extraordinario.
Ley 1996 de 2019. Aspectos procesales relacionados con derogatorias, vigencias y régimen de transición
Authors: Rolong Arias Katherine Andrea
Published: November 2021

Este artículo estudia el régimen de transición de la ley 1996 de 2019 y realiza un análisis del impacto procesal que este conlleva frente a los procesos en curso, terminados y los que pueden ser adelantados, así como en otros procesos jurisdiccionales que se relacionan con este tema. Para ello se realizó un estudio teórico analítico. A partir de lo establecido en la mencionada ley y la jurisprudencia, se analiza la forma en que el nuevo régimen de capacidad genera grandes cambios en el proceso jurisdiccional que requieren de una interpretación ajustada a la Constitución nacional. De esta manera se concluye que, al pasar del régimen de incapacidad al de capacidad, no solo se generó un cambio de paradigma en cuanto a aspectos de naturaleza sustancial, sino que se presentó un gran impacto en las normas de derecho procesal desde el punto de vista de la derogatoria de normas y la entrada en vigencia de otras. Esto se debe a que el procedimiento puede ser iniciado en el régimen de transición. Asimismo, pueden suspenderse los procesos en curso y regular los procesos que se encontraban legalmente terminados para el momento de entrada en vigencia de la ley 1996 de 2019.
Extensive sympatry and frequent hybridization of ecologically divergent aquatic plants on the Qinghai-Tibetan Plateau
Authors: Wu Zhigang , Wang Zhong , Xie Dong , Zhang Juan , Cai Pengsen , Li Xing , Xu Xinwei , Li Tao , Zhao Jindong
Published: November 2021

Hybridization has fascinated biologists in recent centuries for its
evolutionary importance, especially in plants. Hybrid zones are commonly
located in regions across environmental gradients due to more
opportunities to contact and ecological heterogeneity. For aquatic taxa,
intrazonal character makes broad overlapping regions in intermediate
environments between related species. However, we have limited
information on the hybridization pattern of aquatic taxa across an
altitudinal gradient. In this study, we aimed to test the hypotheses
that niche overlap and hybridization might be extensive in related
aquatic plants in alpines. We evaluated the niche overlap in three
related species pairs on the Qinghai-Tibetan Plateau and assessed the
spatial pattern of hybrid populations. Obvious niche overlap and common
hybridization were revealed in all three pairs of related aquatic
plants. The plateau edge and river basins were broad areas for the
sympatry of divergent taxa, where a large proportion of hybrid
populations occurred. Hybrids are also discretely distributed in diverse
habitats on the plateau. Differences in the extent of niche overlap,
genetic incompatibility and phylogeographic history might lead to
inconsistences in hybridization patterns among the three species pairs.
Our results suggested that plateau areas are a hotspot for ecologically
divergent aquatic species to contact and mate and implied that
hybridization may be important for the freshwater biodiversity of
highlands.
Structure-dependence in Initial Decomposition of trans-1,2-Dimethylcyclohexyl Isomers: Kinetic Exploration and Conformational Analysis
Authors: Bian Huiting , Wang Yongjin , Li Jing , Zhao Jun
Published: November 2021

Cyclohexyl radicals are crucial primary intermediates in combustion of
fossil and alternative fuels. They would present the inherent
conformation feature, i.e. diverse conformers retained in
inversion-topomerization pathways, jointly controlled by the varying
radical site and specific spatial positions of alkyl side chains on
“easy-distortion” cyclic ring. These conformers for one radical have
different energies and thermodynamics, and are highly expected to
influence their subsequent decomposition reactions in terms of
energetics and kinetics. To reveal such impact, all conformational
structures and their interconversion mechanisms for
trans-1,2-dimethylcyclohexyl isomers were explored by employing quantum
chemical calculations coupled with transition state theory. Originated
from distinct conformers, all accessible transition states were
explicitly identified in different reaction paths for each type of
intramolecular H-transfer or β-scission, and then were carefully used in
computing rate coefficients. The kinetic predictions demonstrate that
the fairly speedy equilibrium among conformers would be established for
one isomer via conformation before they proceed the initial
decomposition over 300-2500 K. This allows thoroughly evaluating the
contribution of various conformers to the kinetics for multiple paths in
one reaction regarding to their thermodynamic properties. Moreover,
conformational analysis elucidates that H-transfers exhibit strong
structure dependence. Note that the most favorable 1,5 H-transfer is
only feasible for one twist-boat with radical site in axial side chain
accompanied by one isoclinal methyl group. The results for β-scissions
are affected by steric energies and substituent effects remained in
conformational structures. These findings facilitate to finally suggest
the proper kinetic parameters for each decomposition reaction with the
aim of their potential implication in kinetic modelling.
The Influence of Youtube as a Classical Guidance Media on Student Learning Motivation during the Covid-19 Pandemic
Authors: Jannah Khuzaimatul , Baqiyatussolihat Babay , Vernandes Reni
Published: November 2021

This study aims to determine the influence of YouTube as a classical guidance media on learning motivation in students during the COVID-19 pandemic. This experimental research uses Posttest Only Control Group Design. The research population is students of 1st grade SMP 3 Kragilan. The research sample consisted of 40 students through random sampling technique, 20 students were the experimental group and 20 students were the control group. Data collection in this study used a questionnaire. The data in this study were analyzed by independent samples t-test using SPSS 16.0 for Windows. The results of the study obtained t count of 2,329, found t table at a significance level of pada (0.05) of 2,021, which means t table < t count. These results prove that YouTube as a classical guidance media has an influence on student learning motivation during the COVID-19 pandemic. Classical guidance media used youtube has several advantages over other classical guidance service media, by using youtube as a learning media, students are more interested and enthusiastic in participating in classical guidance services
What Motivates Parents to Participate in Their Child’s Brain Gym Therapy
Authors: Yusuf Nadhira Rakhmi , Abidin Zainal
Published: November 2021

The findings in the clinical practice field indicate problems related to the inconsistency of parental participation in the therapy that the child undergoes, namely the absence of parents according to the schedule, non-adherence to the therapist's advice, and premature termination. It raises questions of parents' motivation to participate in their children's therapy while no research in Indonesia examines this topic. The current study aims to understand the description of parents' motivation to participate in their child therapy. This qualitative study was conducted by interviewing 3 mothers (age 23-36 years) whose children (age 3-5 years) undergo brain gym therapy at a psychology bureau in Bandung. They are from the same socioeconomic class, have joined the therapy program for at least one month, and were selected using the purposive sampling technique. The results indicate that the underlying motivation for parental participation in child therapy is parents' need for a change in the child's condition and parents' expectation of the therapeutic outcome. Therapy results that match expectations and positive responses from the environment act as reinforcers that make parents willing to continue participating in child therapy.
HUBUNGAN ANTARA KEHARMONISAN KELUARGA DENGAN KENAKALAN REMAJA SISWA SMK NASIONAL MOJOSARI
Authors: Ambara Ivania Christa
Published: November 2021

AbstractThis study aims to determine whether there is a relationship between family harmony with juvenile delinquency at Mojosari National Vocational School. This study uses quantitative methods with research sampling techniques using probability sampling with disproportionate stratified random sampling method with an error rate of 5%. The total population in this study was 186 students and the number of samples in this study were 135 students of SMK Nasional Mojosari. The data collection tool was a questionnaire with a Likert scale on the variable family harmony and juvenile delinquency. Hypothesis testing using SPSS 20 for Windows with a correlation of r = - 0.516 with a significance of 0.000 (p <0.05) on the relationship between family harmony and juvenile delinquency in Mojosari National Vocational School students. So that there is a significant negative relationship between family harmony with juvenile delinquency at Mojosari National Vocational School. The hypothesis proposed in this study is accepted, meaning that the higher the family harmony, the lower the juvenile delinquency, and conversely the lower the family harmony, the higher the juvenile delinquency.AbstrakPenelitian ini bertujuan untuk mengetahui apakah terdapat hubungan antara keharmonisan keluarga dengan kenakalan remaja di SMK Nasional Mojosari. Penelitian ini menggunakan metode kuantitatif dengan teknik pengambilan sampel penelitian menggunakan probability sampling dengan metode disproportionate stratified random sampling dengan taraf kesalahan 5%. Jumlah populasi dalam penelitian ini adalah 186 siswa dan jumlah sampel pada penelitian ini adalah 135 siswa SMK Nasional Mojosari. Alat pengumpulan data berupa kuesioner dengan skala likert pada variabel keharmonisan keluarga dan kenakalan remaja. Uji hipotesis menggunakan SPSS 20 for Windows dengan korelasi r = - 0,516  dengan signifikansi 0,000 (p < 0,05) pada hubungan keharmonisan keluarga dengan kenakalan remaja pada siswa SMK Nasional Mojosari. Sehingga terdapat hubungan negatif yang signifikan antara keharmonisan keluarga dengan kenakalan remaja di SMK Nasional Mojosari. Hipotesis yang diajukan dalam penelitian ini diterima, artinya semakin tinggi keharmonisan keluarga maka semakin rendah kenakalan remaja, dan sebaliknya semakin rendah keharmonisan keluarga maka semakin tinggi kenakalan remaja.
PERBEDAAN CULTURE SHOCK DITINJAU DARI TIPE KEPRIBADIAN EXTROVERT DAN INTROVERT PADA MAHASISWA KARO UKSW ANGKATAN 2019 YANG BERASAL DARI SUMATERA UTARA
Authors: Manik Yessy Sepgina
Published: November 2021

Mahasiswa yang memilih untuk melanjutkan pendidikan di  luar dari daerah asalnya akan belajar  untuk menyesuiakan diri dengan lingkungan yang baru, sehingga individu yang tidak mampu menyesuaikan diri akan merasakan culture shock. Tujuan penelitian ini adalah untuk mengetahui perbedaan culture shock yang ditinjau dari tipe kepribadian extrovert dan introvert pada mahasiswa, dengan hipotesis terdapat perbedaan antara individu extrovert dan introvert dalam menghadapi culture shock. Sampel penelitian berjumlah 50 orang mahasiswa Karo Universitas Kristen Satya Wacana yang berasal dari Sumatera Utara dan menggunakan teknik total sampling. Pengukuran penelitian ini menggunakan skala culture shock milik Mumford (1997) dengan (r = 0,822) dan skala kepribadian extrovert dan introvert milik Eyesenck yaitu Eyesenck Personality Questionnaire (EPQ) dengan r = (0,847). Analisis hipotesis menggunakan Mann Whitney U Test, yang menunjukkan hasil  signifikan dengan p=0,000 (p<0,05). Dengan demikian, Individu dengan kepribadian extrovert akan memiliki tingkat culture shock yang lebih rendah, sedangkan individu dengan kepribadian introvert akan memiliki tingkat culture shock yang lebih tinggi.
Employee Engagement dan Kinerja Karyawan pada Perusahaan yang ada di Salatiga dan sekitarnya dimasa Pandemi Covid-19
Authors: Prasetyo Daniel adhi
Published: November 2021

Abstract: Changes in working methods in new conditions with work from home have created several new problems for some employees, from limited work tools, workplaces, to poor network access to carry out remote work activities. The hypothesis of this study is a significant positive correlation between employee engagement and employee performance at companies in salatiga and around it. This research is a quantitative correlation with the total number of participants was 30 people at companies in salatiga and around it with data retrieval using purposive sampling technique. Data analysis using Pearson's product moment correlation technique. The results by correlation test shows r = 0.717, with p value = 0.000 (p <0.05). The results indicated that there is a significant positive correlation between employee engagement and employee performance on company employees. It means that the higher employee engagement higher employee performance on company employees and the other way around.
Hubungan Antara Gratitude dengan Stres Kerja Pada Guru Sekolah Luar Biasa
Authors: Pramudani Zefanya Agatha
Published: November 2021

Penelitian ini bertujuan untuk mengetahui hubungan gratitude dengan stres kerja pada guru sekolah luar biasa. Metode penelitian yang digunakan dalam penelitian ini adalah metode kuantitatif. Sampel dalam penelitian ini berjumlah 46 orang yang diambil menggunakan teknik quota sampling. Data penelitian diperoleh melalui wawancara dan kuesioner. Pengumpulan data variable gratitude menggunakan The Gratitude Questionnaires Six Item Form (GQ-6) oleh Michael E. McCullough, Robert A. Emmons, dan Jo-Ann Tsang (2002) yang terdiri dari 6 aitem, sementara variable stres kerja menggunakan Occupational Stress Indicator (OSI) oleh Cooper dan Williams (1988) yang terdiri dari 40 aitem. Analisis data menggunakan analisis korelasi. Hasil penelitian menunjukkan bahwa nilai r = -0,372 ; p > 0,05. Kesimpulan penelitian ini adalah gratitude berhubungan negatif terhadap variabel stres kerja. Kata Kunci: gratitude, stres kerja.
Hubungan antara Self-Efficacy dengan Stress Kerja pada Karyawan CV. Berdikari Putra Abadi
Authors: Muthi Afifah Rista Shabrina
Published: November 2021

Penelitian ini bertujuan untuk melihat hubungan self-efficacy dengan stres kerja pada karyawan CV. X. Penelitian dilakukan di CV. X dengan jumlah 40 karyawan. Teknik pengambilan sampel yaitu pengambilan sampel saturasi. Alat bantu data yang digunakan untuk mengukur efikasi diri yaitu skala dari aspek-aspek menurut Bandura yang dibuat dalam bentuk 18 aitem pernyataan. Sedangkan untuk stres kerja penulis mengukur menggunakan skala menggunakan alat ukur yang diturunkan dari aspek-aspek yang dikemukakan oleh Robbins (2006) yang terdiri dari 28 aitem. Berdasarkan hasil analisis data menggunakan teknik analisis Korelasi Pearson diperoleh 0,853 yang menyatakan adanya hubungan positif dan tingkat hubungan yang sangat kuat antara variabel Self Efficacy (X) dengan variabel Stres Kerja (Y). Selanjutnya dilakukan pengujian terhadap kesalahan yang tidak berhasil untuk menguji nilai r signifikan atau tidak, yang kemudian hasilnya Sig. (2-tailed) yaitu sebesar 0,000 artinya lebih kecil dari alpha 0,05. Sehingga dapat disimpulkan bahwa terdapat hubungan positif dan signifikan antara variabel Self Efficacy (X) dengan variabel Stress Kerja (Y).
Hubungan antara harga diri dengan resiliensi pada perawat petugas Covid-19 di RS St. Elisabeth Semarang
Authors: Stevani Novia , Y. E. Kusumiati Ratriana
Published: November 2021

Penelitian memiliki tujuan untuk mengetahui hubungan antara harga diri dengan resiliensi perawat petugas Covid-19 RSU St. Elisabeth Semarang. Jumlah partisipan yang berada di  penelitian ini sebanyak 50 orang partisipan dengan teknik pengambilan data sampel jenuh. Data dianalisis menggunakan teknik korelasi Product Moment Pearson. Koefisien yang diperoleh sebesar 0,934 dengan signifikansi sebesar 0,000 (p < 0,05) sehingga bisa disimpulkan terdapat hubungan positif antara variabel harga diri dan resiliensi pada perawat petugas Covid-19 di RSU St. Elisabeth Semarang. Hipotesis yang diajukan dalam penelitian ini diterima, artinya semakin tinggi harga diri maka semakin tinggi resiliensi diri seorang perawat petugas Covid-19, dan sebaliknya semakin rendah harga diri maka semakin rendah resiliensi diri seorang perawat petugas Covid-19.