bluuebunny/crossref_metadata_2025 huggingface dataset:
Nitrogen (N) use efficiency and yield in rice under varying types and rates of N source: chemical fertilizer, livestock manure compost and food waste-livestock manure compost
Authors: Sung Jwakyung , Kim Woojin , Oh Taek-Keun , So Yoon-Sup
Published: January 2023

An optimal use of organic composts derived from animal and food wastes could provide an opportunity to achieve both sustainable crop production and soil quality, and a lot of research has provided the evidence. The nitrogen use efficiencies (NUEs) is a definition to evaluate the interaction between crop and nitrogen (N), and, due to this reason, widely used in agriculture. The current work tried to evaluate NUEs as an indicator of N acquisition capacity and physiological responses of rice grown under varying N levels. To do this, we employed different types and rates of nitrogen source, chemical fertilizer, livestock manure-based compost and food waste and livestock manure-containing compost. Despite of the enhanced rice growth and yield by fertilization, a difference by types and rates of fertilization was not observed. Net photosynthetic rate was significantly higher in the treatments of 90–317 N kg ha-1. The NUE (N uptake efficiency × N utilization efficiency) was the highest in lower N application groups, and sharply reduced with an increase in fertilization rates. In contrast, the nitrogen harvest index (NHI, grain N/total biomass N, kg kg-1) showed higher (0.71– 0.76 kg kg-1) in greater N application treatments (≤ 317 N kg ha-1). Accordingly, in terms of NUE, our result suggest that rice may be affordable of the application of less than 300 kg N ha-1 (combination with chemical fertilizer and organic compost). Nevertheless, it should be investigated how excess N application affects soil quality, and how long rice plant and soil can accept excess N without an environmental load.
Suppression of Phytophthora capsici using double-stranded RNAs targeting NLP effector genes in Nicotiana benthamiana
Authors: Park Minsu , Kweon Yujin , Lee Dowhan , Shin Chanseok
Published: January 2023

RNA interference (RNAi) is a gene regulatory mechanism that involves the interaction of small interfering RNAs (siRNAs) and RNA-induced silencing complex (RISC). Dicer cleaves exogenous double-stranded RNA (dsRNA) into siRNAs, which get incorporated into RISC and bind to complementary sequences on the target mRNA to induce its degradation. In this study, we adopted RNAi technology using dsRNAs to suppress Phytophthora capsici, which causes diseases in solanaceous crops, including pepper. We designed and synthesized dsRNAs targeting the P. capsici effector genes PcNLP2 and PcNLP6, respectively. These genes encode necrosis and ethylene-inducing peptide 1-like proteins in P. capsici, which are known to promote oomycete infection. Nicotiana benthamiana leaves were first infiltrated with dsRNAs and inoculated with P. capsici 2 days later. We confirmed significant suppression of P. capsici and PcNLP2, PcNLP6 expression in dsRNA-treated leaves. In addition, we found that downregulation of PcNLP2 and PcNLP6 distinctly affected the expression of some defense-related genes. These results suggest that dsRNA mediated RNAi technology can be used to suppress various pathogens, and may contribute toward crop protection.
Are bacterial coinfections really rare in COVID-19 intensive care units?
Authors: Karaca Banu , Aksun Murat , Karahan Nagihan Altıncı , Girgin Senem , Ormen Bahar , Tuzen Ahmet Salih , Demirdal Tuna , Sencan Atilla
Published: January 2023

Objectives

There are limited data about nosocomial coinfections of COVID-19 cases monitored in the intensive care unit. This study aims to investigate coinfections in COVID-19 patients followed in an intensive care unit of a university hospital.

Methods

This study analyzed retrospectively the data of coinfections of 351 COVID-19 patients in the period 28.02.2020–15.01.2021 in a tertiary care intensive care unit in a university hospital.

Results

Bacterial coinfections were present in 216 of the 351 cases. One hundred and thirty of these cases were evaluated as nosocomial infections. On the third day the Sequential Organ Failure Assessment Score, usage of invasive mechanical ventilation and presence of septic shock were significantly higher in the coinfected group. The neutrophil/lymphocyte ratio, polymorphonuclear leukocyte count, procalcitonin, ferritin, and blood urea nitrogen values were significantly higher in the coinfection group. White blood cells (WBC) (OR: 1.075, 95% CI 1.032–1.121, p = 0.001) and ICU hospitalization day (OR: 1.114, 95% CI 1.063–1.167, p < 0.001) were found to be independent risk factors for coinfection in the multivariate logistic regression analysis. The rates of hospitalization day on the day of arrival, the 21st day, as well as total mortality (p = 0.004), were significantly higher in the coinfected group.

Conclusion

Bacterial coinfections of COVID-19 patients in the intensive care unit remain a problem. Identifying the infectious agent, classifying colonizations and infections, and using the proper treatment of antibiotics are of great importance in the case management of COVID-19 patients in the intensive care unit.
The global prevalence of primary central nervous system tumors: a systematic review and meta-analysis
Authors: Salari Nader , Ghasemi Hooman , Fatahian Reza , Mansouri Kamran , Dokaneheifard Sadat , Shiri Mohammad hossain , Hemmati Mahvan , Mohammadi Masoud
Published: January 2023

Background

Primary central nervous system (CNS) tumors are a heterogeneous group of neoplasms, including benign and malignant tumors. Since there are many heterogeneities in the prevalence reported in previous studies on this type of tumor, this study was performed to determine the overall prevalence of different primary CNS tumors.

Method

The study was conducted as a systematic review and meta-analysis by searching international databases, including PubMed, Scopus, Science Direct, Web of science, and the Google Scholar search engine until August 2020. After transferring the studies to information management software (EndNote) and eliminating duplicate studies, the remaining studies were reviewed based on inclusion and exclusion criteria according to three stages of primary and secondary evaluation and qualitative evaluation. Comprehensive Meta-Analysis software, Begg, Mazumdar, and I2 tests were used for data analysis, publication bias analysis, and heterogeneity analysis, respectively.

Results

After performing the systematic review steps, 80 studies were included for final analysis. Based on 8 studies, the prevalence of brain tumors was 70.9%. Also, studies on 7 other studies showed that the prevalence of spinal tumors was 12.2%. A review of 14 studies showed that the prevalence of neuroepithelial tumors was 34.7%. The analysis of 27 studies reported a prevalence of glioma tumors of 42.8%. Analyses performed on other studies showed that the prevalence of pituitary adenomas was 12.2%, embryonal tumors 3.1%, ependymal tumors 3.2%, meningiomas 24.1%, glial tumors 0.8%, astrocytic 20.3%, oligodendroglial 3.9%, glioblastoma 17.7%, schwannoma 6.7%, medulloblastoma 7.7% and Polycystic astrocytomas 3.8%.

Conclusion

As a result, it can be stated that brain tumors are the most common type of primary CNS tumors. It was also observed that tumors involving neuroepithelial cells are more common in patients than other types of tumors.
siRNA-E6 sensitizes HPV-16-related cervical cancer through Oxaliplatin: an in vitro study on anti-cancer combination therapy
Authors: Shiri Aghbash Parisa , Hemmat Nima , Baradaran Behzad , Bannazadeh Baghi Hossein
Published: January 2023

Background

Persistent infection with high-risk Human papillomaviruses (HPV), such as hr-HPV-16 and hr-HPV-18, lead to cervical cancer, the fourth most common cancer in the world. In the present study, we investigated the alteration of E6 oncogene expression by E6-specific short interfering RNA (siRNA) combined with Oxaliplatin.

Methods

The cervical cancer cell line, CaSki, was transfected with E6-siRNA, then treated with Oxaliplatin. The cellular genes, such as p53, MMP9, Nanog, and caspases expression, were assessed by quantitative real-time PCR. The cell death rate, cell cycle, and cell viability were assessed by Annexin V/PI staining, DAPI staining, and MTT test, respectively. Furthermore, colony formation assay and scratch test determined the stemness ability and cell metastasis, respectively.

Results

Combination therapy increased the re-expression of genes involved in the p53-dependent apoptosis pathway (increase in apoptosis to 44.2%), and reduced stemness and metastasis ability compared to either siRNA or Oxaliplatin monotherapy. Together, our results demonstrate that E6-siRNA and Oxaliplatin combination increased the cervical cancer cells’ sensitivity to Oxaliplatin and decreased the survival rate, proliferation, and metastasis, and consequently escalated apoptosis rate, induced cell cycle arrest in the sub-G1 stage, and reduced the chemotherapy drug dosage.

Conclusion

Inhibition of E6 oncogene expression and subsequent E6-siRNA with Oxaliplatin combination therapy could be a novel strategy for cervical cancer treatment.

Graphical Abstract
The gastrointestinal microbiome in dairy cattle is constrained by the deterministic driver of the region and the modified effect of diet
Authors: Lin Limei , Lai Zheng , Zhang Jiyou , Zhu Weiyun , Mao Shengyong
Published: January 2023

Background

Dairy cattle (Bos taurus), especially Holstein cows, which are the highest-producing dairy animals and are widely bred to provide milk products to humans, rely critically on their associated gastrointestinal tract (GIT) microbiota to digest plant feed. However, the region-specific taxonomic composition and function of the GIT microbiome in dairy cattle and the mechanistic basis for the diet-induced effects remain to be elucidated. 

Results

We collected 120 digesta samples from 10 GIT regions of 12 Holstein cows fed forage- and grain-based diets and characterized their GIT microbiome via functional shotgun metagenomics and the resolution of metagenome-assembled genomes. Our results demonstrated that the GIT microbiome was mainly partitioned into three distinct clusters, four-chambered stomach, small intestine, and large intestine. Moreover, we found that the four-chambered stomach microbiome with the highest diversity had a strong ability to degrade recalcitrant polysaccharide substrates, underpinned by the prevalence of potential cellulosome-­producing and plant-derived polysaccharide utilization loci-encoding consortia. In contrast, the post-gastric intestinal microbiome orchestrated alternative fermentation pathways to adapt to nutrient availability and energy acquisition. Diet shifts selectively modified the metabolic cascades of the microbiome in specific GIT regions, evidenced by the loss of fiber-degrading taxa and increased hydrogen sinks in propionate after grain introduction.

Conclusions

Our findings provide new insights into GIT microbial organization and function in dairy cattle by GIT regions and diet regimes, which offers clues for improving animal production and health in the future.
The structure and diversity of microbial communities in Paederus fuscipes (Coleoptera: Staphylinidae): from ecological paradigm to pathobiome
Authors: Chamankar Bahar , Maleki-Ravasan Naseh , Karami Mohsen , Forouzan Esmaeil , Karimian Fateh , Naeimi Sabah , Choobdar Nayyereh
Published: January 2023

Background

Paederus fuscipes is medically the most famous rove beetle, which causes dermatitis or conjunctivitis in humans, as well as gastrointestinal toxicosis in livestock, via releasing toxic hemolymph containing pederin. Pedrin biosynthesis genes have been identified in uncultured Pseudomonas-like endosymbionts that are speculated to be acquired through a horizontal transfer. However, the composition of the P. fuscipes microbial community, especially of the gut and genital microbiome, remains unclear. This study was aimed to characterize the structure and diversity of P. fuscipes-associated bacterial communities in terms of gender, organ, and location using the Illumina HiSeq platform in the southern littorals of Caspian Sea.

Results

The OTUs identified from P. fuscipes specimens were collapsed into 40 phyla, 112 classes, 249 orders, 365 families, 576 genera, and 106 species. The most abundant families were Pseudomonadaceae, Spiroplasmataceae, Weeksellaceae, Enterococcaceae, and Rhizobiaceae, respectively. Thirty top genera made up > 94% of the P. fuscipes microbiome, with predominating Pseudomonas, followed by the Spiroplasma, Apibacter, Enterococcus, Dysgonomonas, Sebaldella, Ruminococcus, and Wolbachia. Interesting dissimilarities were also discovered within and between the beetle microbiomes in terms of genders and organs. Analyses showed that Spiroplasma / Apibacter as well as Pseudomonas / Pseudomonas were the most abundant in the genitals / intestines of male and female beetles, respectively. Bacterial richness did not display any significant difference in the three provinces but was higher in male beetles than in females and more in the genitals than intestines.

Conclusions

The present study identified Pseudomonas-like endobacterium as a common symbiont of P. fuscipes beetles; this bacterium begins its journey from gut and genitalia of females to reach the male rove beetles. Additionally, male and female rove beetles were characterized by distinctive microbiota in different organs, likely reflecting different functions and/or adaptation processes. Evidence of the extension of P. fuscipes microbiome from the environmental paradigm to the pathobiome was also presented herein. A comprehensive survey of P. fuscipes microbiome components may eventually lead to ecological insights into the production and utilization of defensive compound of pederin and also the management of linear dermatitis with the use of available antibiotics against bacterial pathogens released by the beetles.
Lab and field evaluation of tagging methods for the use of acoustic telemetry to observe sea urchin movement behaviour at ecologically relevant spatio-temporal scales
Authors: MacGregor Kathleen A. , Lavoie Marie-France , Robinson Shawn M. C. , Simard Émilie , McKindsey Christopher W.
Published: January 2023

Background

Acoustic telemetry allows detailed observations of the movement behaviour of many species and as tags get smaller, smaller organisms may be tagged. The number of studies using acoustic telemetry to evaluate marine invertebrate movement is growing, but novel attachment methods include unknowns about the effects of tagging procedures on individual survival and behaviour. This study compared methods of tag attachment on green sea urchins (Strongylocentrotus droebachiensis) to determine the feasibility of using acoustic transmitters to track echinoid movement. Four tagging methods were compared in the lab and tag retention, urchin condition, and survival analysed. Two tagging methods (Dyneema® fishing line and T-bar tags) were evaluated in the field using an existing acoustic telemetry array. Urchins were tagged and the study area revisited one week and 2 months post-release by scuba divers to estimate movement and tag retention.

Results

The best methods in the lab, with high tag retention, survival, and minimal effects on urchin condition, were fishing line methods. T-bar tags, although showing high tag retention, caused significant mortality and had deleterious long-term effects on urchin condition and behaviour. After 2 months in the field, as in the lab, fishing line was a more effective tagging method. Urchins tagged with fishing line showed increased estimates of space occupancy compared to T-bar-tagged urchins and a single fishing-line tagged individual was found by divers in good health after 80 days. Combined, these laboratory and field results demonstrate the feasibility of using acoustic telemetry to observe urchin movement.

Conclusions

Results strongly suggest that surgical attachment methods that minimize injuries at the attachment site should be prioritized for echinoid tagging studies. Together, lab and field tests indicate that acoustic telemetry is a promising method to examine marine echinoid movement over ecologically relevant spatial and temporal scales.
Negative association between harsh parenting and life satisfaction: negative coping style as mediator and peer support as moderator
Authors: Ma Chensen , Song Jingjing
Published: January 2023

Background

Previous research has demonstrated that harsh parenting negatively affects children’s psychological development. This study examined the association between harsh parenting during childhood and life satisfaction of Chinese college students. We further looked at whether this association is explained in part by negative coping styles, and whether peer support lessens the potential effect of harsh parenting on negative coping styles and life satisfaction.

Method

The sample included 609 Chinese students (aged 17–21 years,M = 18.39,SD = 0.82). The participants responded to questionnaires measuring past experiences with harsh parenting, life satisfaction, negative coping styles, and peer support.

Results

Regression analysis showed that harsh parenting negatively contributed to students’ life satisfaction via the mediator of negative coping styles, and peer support moderated this negative relationship. Specifically, the negative impact of harsh parenting on life satisfaction was only significant when there was low peer support. The effect of harsh parenting on negative coping styles was higher in individuals with high peer support than in those with low peer support.

Conclusion

This study highlights the roles of intrinsic (negative coping style) and extrinsic (peer support) factors in understanding the negative effects of harsh parenting on adolescents’ life satisfaction. These results provide insight into how to enhance adolescents’ life satisfaction by reducing harsh parenting and negative coping styles and by promoting peer support.
Functional testing, coronary artery calcifications, and outcomes in Hodgkin lymphoma survivors treated with chest radiation
Authors: Divakaran Sanjay , Lopez Diana M. , Parks Sean M. , Hainer Jon , Ng Andrea K. , Blankstein Ron , Di Carli Marcelo F. , Nohria Anju
Published: January 2023

Background

Consensus guidelines recommend periodic screening for coronary artery disease (CAD) in Hodgkin lymphoma (HL) survivors treated with radiation therapy (RT) to the chest. However, the prognostic utility of screening strategies in this population remains unclear. We evaluated the association between functional testing, coronary artery calcifications (CAC), and guideline-based risk assessment and major adverse cardiovascular events (MACE) in HL survivors treated with RT.

Methods

We retrospectively studied HL survivors treated with RT who underwent functional testing between 2003 and 2020 and chest computed tomography (CT) within 12 months of each other at our center. CAC was assessed semi-quantitatively from CT images. Cardiovascular risk was estimated using the 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease. Diagnostic test characteristics were calculated using major adverse cardiac events (MACE) during follow-up as the gold standard.

Results

The study included 159 patients (median age at functional testing 48 years, median age at HL diagnosis 27 years, 62.9% female). Abnormal functional testing had the highest specificity (94.2% (95% CI 88.4%-97.6%)) and positive likelihood ratio (4.55 (95% CI 1.86–11.13)) while CAC had the highest sensitivity (63.2% (95% CI 46.0%-78.2%)) and lowest negative likelihood ratio (0.52 (95% CI 0.34–0.80)). Specificity for ACC/AHA risk assessment was also high (88.5% (95% CI 81.1%-93.7%)). Over 3.3 years of follow-up, abnormal functional testing (adjusted subdistribution hazard ratio (SHR) 5.10, 95% CI 2.41 – 10.78, p < 0.001) and CAC (adjusted SHR 3.58, 95% CI 1.35 – 9.47, p = 0.010) were both significantly associated with MACE.

Conclusions

In HL survivors treated with RT, both abnormal functional testing and ACC/AHA risk assessment had high specificity for subsequent MACE, but CAC had higher sensitivity. Further research is needed to inform CAD screening and primary prevention strategies in this population.
“You need a team”: perspectives on interdisciplinary symptom management using patient-reported outcome measures in hemodialysis care—a qualitative study
Authors: Baragar Brigitte , Schick-Makaroff Kara , Manns Braden , Love Shannan , Donald Maoliosa , Santana Maria , Corradetti Bonnie , Finlay Juli , Johnson Jeffrey A. , Walsh Michael , Elliott Meghan J.
Published: January 2023

Background

Patient-reported outcome measures (PROMs) are standardized instruments used for assessing patients’ perspectives on their health status at a point in time, including their health-related quality of life, symptoms, functionality, and physical, mental, and social wellbeing. For people with kidney failure receiving hemodialysis, addressing high symptom burden and complexity relies on care team members integrating their expertise to achieve common management goals. In the context of a program-wide initiative integrating PROMs into routine hemodialysis care, we aimed to explore patients’ and clinicians’ perspectives on the role of PROMs in supporting interdisciplinary symptom management.

Methods

We employed a qualitative descriptive approach using semi-structured interviews and observations. Eligible participants included adult patients receiving intermittent, outpatient hemodialysis for > 3 months, their informal caregivers, and hemodialysis clinicians (i.e., nurses, nephrologists, and allied health professionals) in Southern Alberta, Canada. Guided by thematic analysis, team members coded transcripts in duplicate and developed themes iteratively through review, refinement, and discussion.

Results

Thirty-three clinicians (22 nurses, 6 nephrologists, 5 allied health professionals), 20 patients, and one caregiver participated in this study. Clinicians described using PROMs to coordinate care across provider types using the resources available in their units, whereas patients tended to focus on the perceived impact of this concerted care on symptom trajectory and care experience. We identified 3 overarching themes with subthemes related to the role of PROMs in interdisciplinary symptom management in this setting: (1) Integrating care for interrelated symptoms (“You need a team”,conducive setting, role clarity and collaboration); (2) Streamlining information sharing and access (symptom data repository,common language for coordinated care); (3) Reshaping expectations (expectations for follow-up,managing symptom persistence).

Conclusions

We found that use of PROMs in routine hemodialysis care highlighted symptom interrelatedness and complexity and helped to streamline involvement of the interdisciplinary care team. Issues such as role flexibility and resource constraints may influence sustainability of routine PROM use in the outpatient hemodialysis setting.
Perceptual differences in nursing implementation leadership and climate: a cross-sectional study
Authors: Shuman Clayton J. , Ehrhart Mark G. , Veliz Philip T. , Titler Marita G.
Published: January 2023

Background

The literature on perceptual differences between managers and staff regarding social dynamic factors (e.g., leadership, climate) in nursing settings is sparse. Addressing this gap in knowledge is critical for informing implementation efforts and improving patient and organizational outcomes. The purpose of this study was to test the perceptual differences regarding implementation leadership and implementation climate between nursing staff and their managers.

Methods

This study was a secondary analysis of cross-sectional survey data collected in 2016–2017. The setting included 22 adult medical-surgical units nested in 7 acute care hospitals in the Eastern and Midwestern United States. Participants were registered nurses (N = 261) and nurse managers (N = 22) who completed an electronic survey consisting of the Implementation Leadership Scale (ILS), the Implementation Climate Scale (ICS), and demographic items. Differences in perception were analyzed at the unit level using structural equation modeling to develop latent difference score models (LDS). We assessed associations of the LDSs with manager ILS and ICS scores, years of nursing experience, and years of experience working on the current unit. The association of ILS LDS with the observed nursing staff ICS scores was also analyzed.

Results

Higher manager scores on the ILS and ICS were associated with greater perceptual differences in implementation leadership and implementation climate. Greater years of experience as a nurse were associated with greater perceptual differences in ILS and ICS scores. Greater tenure on the unit was associated with smaller differences on the ILS knowledge domain. Greater perceptual differences regarding implementation leadership were associated with worse staff ratings of implementation climate.

Conclusions

Although this study observed significant relationships among manager ILS and ICS scores, staff-manager perceptual differences, and staff ratings of implementation climate in nursing settings, it is still unclear why perceptual differences in implementation leadership and climate exist and how to address them. Future studies are warranted to test the effect of perceptual differences on implementation and patient outcomes.
Classification of failure modes of pipelines containing longitudinal surface cracks using mechanics-based and machine learning models
Authors: Sun Haotian , Zhou Wenxing
Published: January 2023

This paper applies the mechanics-based approach and five machine learning algorithms to classify the failure mode (leak or rupture) of steel oil and gas pipelines containing longitudinally oriented surface cracks. The mechanics-based approach compares the nominal hoop stress remote from the surface crack at failure and the remote nominal hoop stress to cause unstable longitudinal propagation of the through-wall crack to predict the failure mode. The employed machine learning algorithms consist of three single learning algorithms, namely naïve Bayes, support vector machine and decision tree; and two ensemble learning algorithms, namely random forest and gradient boosting. The classification accuracy of the mechanics-based approach and machine learning algorithms is evaluated based on 250 full-scale burst tests of pipe specimens collected from the open literature. The analysis results reveal that the mechanics-based approach leads to highly biased classifications: many leaks erroneously classified as ruptures. The machine learning algorithms lead to markedly improved accuracy. The random forest and gradient boosting models result in the classification accuracy of over 95% for ruptures and leaks, with the accuracy of the decision tree and support vector machine models somewhat lower. This study demonstrates the value of employing machine learning models to improve the integrity management practice of oil and gas pipelines.
Iatrogenic bile duct injuries after laparoscopic cholecystectomy: evaluation by MRCP before management
Authors: Abdelgawad Mohamed Saied , Eid Mohamed , Abokoura Sameh , Elmazaly Mohamed Amin , Aly Rasha Abdelhafiz
Published: January 2023

Background

Iatrogenic bile duct injuries are unusual but possibly associated with fatal complications with increased incidence since the introduction of laparoscopic cholecystectomy. Appropriate estimation of these injuries is essential for proper management. Imaging is vital for the initial diagnosis, extent assessment and consequently, treatment guidance of bile duct injury with an ideal outcome. In this study, MRCP was carried out in 37 cases (28 females and 9 males, age range from 19 to 58 years) with suspected BDI following laparoscopic cholecystectomy. MRCP images were assessed for bile duct transection injury, strictures, biliary leakage, and intrahepatic biliary radicles (IHBR) dilatation. In positive cases, Strasberg classification system was used with the definitive diagnosis was done regarding the surgical findings and/or findings on endoscopic retrograde cholangiopancreatography (ERCP) or percutaneous transhepatic cholangiography (PTC).

Results

Our study includes 37 cases with biliary injuries. On MRCP our cases were stratified regarding the Strasberg-Bismuth classification into five types (A to E). Most BDIs were type E2 (29.7%), followed by type E1 (18.9%), type A (16.2%), type E3 (10.8%), type E4 (8.2%), type C (5.4%), and type D and finally type E5 and B injuries with each one representing 2.7%. Twenty cases presented with biliary leakage and seventeen with bile duct obstruction, whether duct ligation or stricture.

Conclusion

MRCP is an essential imaging modality for assessment of iatrogenic BDIs enabling the radiologists to classify these injuries and helps to govern the management.
el-Metâlibü’l-âliye’nin Kayıp Ciltlerinin Peşinde
Authors: Altaş Eşref
Published: January 2023

Bu araştırma notu, Râzî’nin el-Metâlibü’l-âliye adlı eserinin, epistemoloji, mantık ve ontoloji kısımlarını içeren ve şimdiye kadar kullanılmayan bir nüshasını ve bu nüshanın içeriğini tanıtmaktadır (Süleymaniye Kütüphanesi, Fatih 3145). Bununla yazı, Sekkâ neşrinin sebep olduğu el-Metâlibü’l-âliye’nin adı ve kapsamıyla ilgili iki temel yanlışı düzeltmekte ve el-Metâlibü’l-âliye’nin mantık, ontoloji, fizik ve teoloji kısımlarını içeren kuşatıcı bir ansiklopedik eser olduğunu göstermeyi amaçlamaktadır.
Natalia Bachour. Oswaldus Crollius und Daniel Sennert im frühneuzeitlichen Istanbul: Studien zur Rezeption des Paracelsismus im Werk des osmanischen Artzes Ṣāliḥ b. Naṣrullāh ibn Sallūm al-Ḥalabī
Authors: Aksoy Esra
Published: January 2023

değerlendirme
Natalia Bachour. Oswaldus Crollius und Daniel Sennert im frühneuzeitlichen Istanbul: Studien zur Rezeption des Paracelsismus im Werk des osmanischen Artzes Ṣāliḥ b. Naṣrullāh ibn Sallūm al-Ḥalabī
Authors: Aksoy Esra
Published: January 2023

Değerlendirme.
Taşköprīzāde on the (Occult) Science of Plague Prevention and Cure
Authors: Melvin-Kushki Matthew
Published: January 2023

The genre of the plague treatise, still little studied, testifies to the cultural transformations that swept western Eurasia after the Black Death apocalypse of the mid-fourteenth century, with recurrent outbreaks for centuries thereafter. Ottoman contributions to this genre are exemplary: they allow us to track the emergence of an imperial-scientific early modernity. This article presents the most comprehensive and innovative Islamicate plague treatise extant, Taşköprīzāde Aḥmed’s (d. 1561) Treatise on Healing Epidemic Diseases. Therein the celebrated Ottoman polymath makes a strong case, advanced by arguments both religious and rational, for occult science as the most empirical method for preventing and curing the plague. To this end, he devotes the theoretical first half of the treatise to a critique of fatalist scholars and sufis, who prefer tawakkul to tasabbub, or blind faith to “scientific method”; the practical second half is devoted to what he considers to be the most medically effective scientific discipline of his era, lettrism (ʿilm al-ḥurūf)—a Neopythagorean science encapsulating the new “cosmological imaginary” of Western early modernity generally, wherein the world was seen by many thinkers and doers as a mathematical and hence magically tractable text. Our distaste for occult science notwithstanding, Taşköprīzāde must here be named another early modern empiricist.
Post-Classical Islamic Philosophy – a Contradiction in Terms?
Authors: Kaukua Jari
Published: January 2023

This paper engages critically with Dimitri Gutas’ recent characterization of post-classical Islamic philosophy and theology as a form of paraphilosophy or intellectual activity that merely simulates philosophy. I argue that this view arises from a misguided understanding of the concept of philosophy that should provide the standard for its historiography. In order to avoid a number of problematic consequences, such as gaps in historical continuity or a disconnection from what we understand by philosophy today, we must take our cue from a sufficiently uncontroversial contemporary concept of philosophy instead of any particular historical concept, such as the Peripatetic amalgam of metaphysics, theory of science, and the empirical sciences. Such a strategy provides a sound basis for the inclusion of post-classical thinkers, as well as many classical thinkers who are not falāsifa, in the history of Islamic philosophy without vicious circularity or loss of a normative concept of philosophy
Rule of the One: Avicenna, Bahmanyār, and al-Rāzī on the Argument from the Mubāḥathāt
Authors: Dadikhuda Davlat
Published: January 2023

Avicenna is a strong proponent of what some of the later ones call qāʻidat al-wāḥid or ‘rule of the one’ (RO). The gist of RO states: from the one only one directly proceeds. In the secondary literature, discussion of this Avicennian rule is usually limited to a particular application of it i.e., the issue of emanation. As result, it’s not really clear what RO means, nor why Avicenna endorsed it. In this paper, I try and remedy this situation by doing two things – one on the taṣawwur front, the other on the tasdīq. First, explain just what the terms of RO amount to – that is, its subject and predicate. In doing this, I distinguish between a narrow and a broad understanding of RO, and the show that, on the Avicennian view, the scope of RO is broad; it is meant to be a general principle of efficient causality. This is why it is appealed to in various contexts to establish substantial philosophical theses. Second, I consider an argument Avicenna offers for RO in the Mubāḥathāt. In unpacking it, I uncover some of its realist presuppositions, and then further clarify it in light of a critique first raised by Bahmanyār and then later made famous by Fakhr al-Dīn al-Rāzī. I then conclude by seeing whether the Avicennian has the resources within the initial premises of the argument to meet the objection that’s raised.
Ebü’l-Berekât el-Bağdâdî’de İlahi Önbilgi ve İnsanın Özgür İradesi Üzerine
Authors: Shehata Mariam
Published: January 2023

İşbu makale Ebü’l-Berekât el-Bağdâdî’nin (ö. 560/ 1164-65’ten önce) ilâhî önbilgi ve insanın özgür iradesi sorununa dair konumunu tetkik etme amacındadır. Metin, Ebü’l-Berekât’ın ilâhî önbilgi ve insanın özgür iradesinin bağdaşması argümanın geçerli olmadığını düşündüğünü iddia ediyor. Bir kişi ya ilâhî önbilgiyi ya da insanın özgür iradesini savunabilir, başka bir çözüm yoktur. Kitâbu’l-Mu‘teber fi’l-hikme adlı kitabının mantık ve metafizik bölümleri içerisindeki bu meseleye dair açıklamalarını inceleyerek, Ebü’l- Berekât’ın ikinci alternatifi seçtiği belirgin kılınacaktır.
Gerçekçiliğin Dönüşümü: İbn Sînâcı Felsefede Tümellerin Ontolojisi ve Kutbüddin er-Râzî’nin Zihnî Misaller Teorisi Üzerine
Authors: Üçer İbrahim Halil
Published: January 2023

Zihnî temsillerin onto-epistemolojik statüsü İbn Sînâ sonrası felsefenin en tartışmalı problemleri arasında görülebilir. Problemin kökenleri bir yandan İbn Sînâ’nın farklı varlık düzlemleri arasında yüklemsel birlik elde etme teşebbüsünde, diğer yandan Fahreddin er-Râzî’nin zihnî varlık ve zihnî misallerin tümelliği eleştirisinde bulunur. Fahreddin er-Râzî’nin eleştirileri İbn Sînâ’nın önde gelen takipçilerini, İbn Sînâ’nın mahiyetlerin farklı varlık seviyelerinde korunumu ilkesini ve onun bilgiyi doğanın gayrimaddi temsili olarak tanımlamasını yeniden düşünmeye sevk etmiştir. Fahreddin er-Râzî’nin eleştirilerine karşı Nasîrüddin et-Tûsî mahiyetlerin ontolojik kapsamını daraltmış ve tümel yüklemlemeyi yeniden tanımlamıştır. Kutbüddin er-Râzî’nin tartışmaya dâhil olması daraltma çabalarını daha ileri bir seviyeye taşımıştır. Tûsî’nin mahiyetlere sadece epistemolojik bir rol vererek onların ontolojik kapsamında yaptığı daraltmaya ilaveten Kutbüddin er- Râzî mahiyetlerin epistemolojik kapsamında da daraltmaya gitmiş ve İbn Sînâ’nın aklî suretlerini, hiçbir şekilde tümel olması mümkün olmayan, tikel bir zihindeki tikel suretler olarak değerlendirmiştir. Ayrıca Tûsî’yle birlikte, kendinde mahiyetlerin hariçteki fertler arasında müşterek varlığını reddeden Kutbüddin er-Râzî, bu iki adımdan yola çıkarak mutabakat ve tümellik tasavvurlarını yeniden tanımlamış, İbn Sînâ’nın hilomorfik cevher teorisi için mereolojik olmayan bir yorum geliştirmiştir. Bu makale İbn Sînâcı felsefede on üçüncü yüzyıldan itibaren ortaya çıkan bu adımları, İbn Sînâ’ya özgü gerçekçiliğin dönüşümü olarak okumakta ve bu dönüşüme giderek artan zihinselci bir eğilimin eşlik ettiğini öne sürmektedir.
Methodological support of the educational process: digital control and evaluation tools for conducting current control and intermediate certification in the discipline "Excursion study of nature at school" for students of the training direction 44.03.01 Pedagogical education, orientation (profile) Biology
Authors: Goncharova O.V.
Published: January 2023

The paper presents guidelines for preparing students for practical classes. For practical exercises, control questions, basic terms on the topic, calculation and situational tasks, test tasks are given. Tasks for independent extracurricular work of students, topics of essays are also given.
Family stories: investigating trauma-informed narratives, change behaviours and environments in complex family experiences
Authors: Maynard Emma , Sims-Schouten Wendy , Fairchild Nikki , Warhurst Amy
Published: January 2023

This article presents our Family Stories model identifying self-reported change behaviours and environments by families developed from our two-phase research in an inner-city area in the south of England. The research focused on parents whose families had experienced complex issues affecting the behaviour, wellbeing, learning and/or safety of children, and who had received social care support from services that had broadly adopted a trauma-informed approach. We identified parents’ self-reported change behaviours and environments, in the context of the high rate of families relapsing and returning for multiple episodes of support. We also identify key challenges to securing long-term positive change, including the barriers to nurturing a strong and successful parenting identity, in which parents are more able to sustain positive change. Our model identifies four enablers, evident in the self-reported change behaviours narrated by our participants: community, allyship, strategy and mastery.
Attitudes of young people in Germany towards parental involvement in paid work: evidence of intergenerational transmission
Authors: Kleinschrot Leonie , Bernhardt Janine , Heintz-Martin Valerie , Zerle-Elsäßer Claudia
Published: January 2023

This article examines young people’s attitudes towards parental involvement in paid work and their association with two channels of intergenerational transmission – parents’ employment arrangements and gender ideologies – the relative importance of these channels and if young people’s gender moderates the association. The data came from a German two-wave panel study of 609 adolescents (aged 15–21) surveyed in 2018 and their mothers in 2013–15. Analyses show that young people’s preferred weekly working hours for mothers were positively related to their parents’ employment arrangements and gender ideologies four years earlier. In contrast, the more progressive their mother’s gender ideology was, the fewer working hours young people preferred for fathers. The two transmission channels were nearly equally important and their impact did not differ between female and male adolescents. Our findings suggest that the intergenerational transmission of gender roles might be one of multiple factors contributing to stalling trends in gender equality.
Love, cynicism, wanderlust: the role of emotions in the career trajectories of precarious journalists
Authors: Lukan Tinca , Čehovin Zajc Jožica
Published: January 2023

This article addresses a lacuna in the literature on the ‘emotional turn’ in journalism by examining how emotions shape journalists’ career trajectories. In-depth interviews conducted at two points in time reveal that love leads journalists to accept precarious work. Over the years, cynicism developed. Cynicism shaped careers in two ways: some moved into public relations and expressed emotions of relief. Others left media organisations to work as freelance journalists, expressing emotions of wanderlust and love. We address the ambivalence of love as an emotion. It leads journalists to accept precarious work that prevents investigative journalism. However, love of journalism has led others to pursue careers outside of media organisations that offer more freedom of expression, which is crucial for democracy.
Comparison of topical 0.03% tacrolimus and homologous injectable platelet-rich plasma in the treatment of keratoconjunctivitis sicca in dogs
Authors: Estanho Giovana José Garcia , Passareli João Victor Goulart Consoni , Pando Letícia da Silva , Vieira Daniel Espinhosa , Nai Gisele Alborghetti , Santarém Cecília Laposy , Andrade Silvia Franco
Published: January 2023

Background and Aim: Keratoconjunctivitis sicca (KCS) is predominantly an immune-mediated chronic inflammatory ocular disease that is commonly diagnosed in dogs. This study aimed to compare the conventional use of topical immunosuppressant tacrolimus 0.03% eye drops and a new therapy injectable homologous platelet-rich plasma (HPRP) into the third eyelid gland and inferior and superior palpebral conjunctiva of dogs with KCS.

Materials and Methods: A total of 66 eyes from 33 dogs were evaluated. The eyes were divided into three equal groups: Negative control group, tacrolimus group (TG), and homologous platelet-rich plasma group (HPRPG). The animals were evaluated using the Schirmer's tear test-1 (STT-1), osmolarity test (OT), strip meniscometry test (SMT), tear film break-up test (TBUT), fluorescein test, lissamine green test (LGT), and cytological and histopathological analyses.

Results: In TG, there was a significant increase (p < 0.05) in the STT-1 and SMT values, and goblet cell count in the palpebral conjunctiva by the end of the study. In HPRPG, 36% (four dogs) received three applications, 55% (six dogs) received two applications, and 9% (one dog) received one application before the initial ocular signs improved. There was a significant decrease (p < 0.05) in the lymphocyte and neutrophil counts of the palpebral conjunctiva in HPRPG than in TG. Both groups showed equivalent improvements in TBUT, OT, and LGT values.

Conclusion: Tacrolimus 0.03% eye drops were more efficient than HPRP in increasing tear production and the number of goblet cells. However, injectable HPRP was more efficient than tacrolimus in decreasing the number of conjunctival inflammatory cells. Treatment with injectable HPRP requires an average of two to three applications, is safe and feasible, and can be used as a cheaper alternative or as an adjuvant to conventional treatment with topical immunosuppressants.
Relationship Marketing Strategies in the Dimension Stone Sector
Authors: Guidi Antonio Carlos , Pizzinatto Nadia Kassouf
Published: January 2023

This research investigated the most effective relationship marketing (RM) strategies in the US dimension stone sector (DSS) market: the overall objective of this research was to investigate which RM strategies are the most suitable, in order to improve the international dimension stone market. Methodologically, qualitative research was implemented, focusing on grounded theory. We interviewed three Brazilian distributors established in the USA, and fifteen national distributors who export dimension stones. Data analysis indicated that the RM strategies which best suited the sector in the American market were: prospecting for new customers, international partnerships, and customer loyalty. Thus, we identified the profile which best suited American consumer potential.
Estimation of uniaxial compressive and indirect tensile strengths of intact rock from Schmidt hammer rebound number
Authors: Fadhil Amjad Ibrahim , Al-Adly Ahmed Ibrahim Fadhil , Fattah Mohammed Y.
Published: January 2023

A number of destructive and non-destructive tests were conducted on rock samples collected from various zones in northern Iraq. So far, for Iraqi rocks, few studies have correlated Schmidt hammer rebound (R) with both unconfined compressive strength (UCS) and Brazilian tensile strength (BTS). In this study, the objective is to develop a relationship between the rebound number of Schmidt hammer surface hardness (rebound number) and both the BTS and the unconfined compressive strength (UCS) of different types of northern Iraqi rocks. The required relationship should be based on measured values of the UCS, BT, and Schmidt hammer hardness. To determine the relationship between R and both the UCS and BTS, 120 intact rock samples were prepared and tested using a uniaxial compressive test machine, a Brazilian test apparatus, and an L-type Schmidt hammer test (BTS). Three different types of rock samples (sandstone, claystone, and limestone) were collected from several locations in northern Iraq (Domeez, Baadra, and Zawita). For the three types of rocks, a new linear correlation with a high value of the regression coefficient R
2 is presented, linking the UCS and BTS separately versus R. For the three types of rocks studied, the correlation between UCS and R is better than the correlation between Brazilian tensile strength (BTS) and R.
Enhancing performance and optimization of multichannel bidirectional WDM-PON with hybrid optical amplifiers employing diverse post dispersion compensation schemes
Authors: Parkash Sooraj
Published: January 2023

This paper is successfully demonstrated simulative comparison and investigation of 32 channels with 0.8 nm frequency spacing bidirectional wavelength division multiplexing passive optical network (WDM-PON) having 640 and 320 GB/s data rate in downstream and upstream transmission by using CRZ-DPSK/NRZ modulation formats respectively. The maximum reach of the system has been configured to 100 km by employing different post-dispersion compensation techniques such as EDC, DCF, OPC, and FBG in uplink and downlink transmission for compensate the effect of chromatic dispersion in propagating channel. An EDFA optical amplifier is placed after DCF for boosting the amplitude of weak signals downstream. Apart from this, the RSOA amplifier is installed at the ONT end for reflecting and re-modulates the same wavelengths to the CO terminal without using any external optical light source. The performance comparison of distinct compensation schemes are evaluated in terms of BER, Q factor, and Eye diagrams. It has been observed that the FBG and DCF are more robust compensation techniques as compared to EDC and OPC in the bidirectional WDM-PON. The maximum satisfying value of BER has been observed in downlink and uplink transmissions are 10−26 and 10−13 for FBG and DCF respectively.