bluuebunny/crossref_metadata_2025 huggingface dataset:
Reconocimiento gestual con Kinect para detectar comportamientos inseguros en conductores
Authors: Esquivel González Diana
Published: November 2020

Los comportamientos inseguros por parte del conductor de un vehículo, como el uso de undispositivo celular durante la conducción, son unas de las principales causas de accidentesde tránsito alrededor del mundo. Esta práctica es difícil de regular y controlar, mas con el usode un sistema automatizado de detección de gestos que indique un comportamiento peligroso,es posible. El uso de cámaras con sensores de profundidad en 3D permite analizar objetos ypersonas en tiempo real con una alta precisión, identificando rasgos y figuras. Estos sensoresutilizan una tecnología denominada “point cloud”, la cual emite un arreglo de luz láser y mideel tiempo de regreso hacia el sensor, determinando la profundidad de cada uno de los puntos.Esta tecnología permitió realizar una aplicación de reconocimiento de gestos que es capazde detectar de manera automática la acción que indica que el conductor está utilizando undispositivo celular durante el tiempo de conducción. Utilizando algoritmos de substracciónde fondo, análisis de rasgos y análisis de histogramas se consiguió realizar inicialmente unasimulación funcional en el programa V-Rep que es capaz de detectar el gesto que indicaeste comportamiento. Posteriormente, se implementó un prototipo utilizando imágenes realestomadas con un Kinect que fueron procesadas en el programa Octave con los mismos algoritmosutilizados en la simulación, para así probar la efectividad de la aplicación desarrollada.
Hubungan antara Efikasi Diri dengan Kualitas Hidup Pasien Hipertensi di wilayah kerja Puskesmas Silo Jember
Authors: Susanti Lilis , Murtaqib Murtaqib , Kushariyadi Kushariyadi
Published: November 2020

Hipertensi merupakan peningkatan tekanan darah sistolik >140 mmHg dan diastolik >90 mmHg. Hipertensi dapat menyebabkan kualitas hidup rendah, hal ini dikarenakan efek dari penyakit. Salah satu faktor yang dapat mempengaruhi kualitas hidup adalah efikasi diri. Efikasi diri merupakan keyakinan diri dalam kemampuan seseorang untuk menghasilkan suatu pencapaian. Penelitian ini bertujuan untuk menganalisis hubungan antara efikasi diri dengan kualitas hidup pasien hipertensi di Wilayah Kerja Puskesmas Silo Jember. Desain penelitian menggunakan korelasional analitik dengan pendekatan cross sectional. Pengumpulan data pada variabel efikasi diri menggunakan kuesioner general perceived self efficacy scale dan pada variabel kualitas hidup menggunakan kuesioner whoqol-bref. Analisis data menggunakan uji spearmen rank dengan tingkat signifikansi 0,05. Hasil penelitian menunjukkan bahwa efikasi diri pada kategori baik yaitu 76,9 %. Nilai kualitas hidup pada kategori sedang yaitu 70,3%. Terdapat hubungan antara efikasi diri dengan kualitas hidup pasien hipertensidi wilayah kerja Puskesmas Silo Jember (p value < 0,001; r= 0,356). Semakin tinggi efikasi diri maka akan semakin baik kualitas hidupnya. Perawat dapat memberikan edukasi maupun motivasi dalam meningkatkan efikasi diri pasien hipertensi.
Pengaruh Therapeutic Exercise Walking terhadap Sirkulasi Darah Perifer pada Pasien Diabetes Melitus Tipe 2 di Kelurahan Gebang Kecamatan Patrang Kabupaten Jember. (The Effect of Therapeutic Exercise Walking on Pheripheral Blood Circulation in Patients wit
Authors: Dewi Erti Ikhtiarini , Yollanda Amadea , Widayati Nur , Rondhianto Rondhianto
Published: November 2020

Pathological change experienced by patients with type 2 diabetes mellitus is impaired peripheralblood circulation, especially in the lower limbs and feet. Peripheral blood circulation can be examinedby measuring Ankle Brachial Index (ABI). Therapeutic exercise walking is one of physical activitieswhich can improve blood circulation. This research goal was to analyze the effect of therapeuticexercise walking on peripheral blood circulation in patients with type 2 diabetes mellitus. Theresearch design was randomized control group pretest-posttest design. The sample size was 15respondents as control group and 15 respondents as treatment group. Data was analyzed by usingdependent t-test and independent t-test with significant level of 0.05. This result showed a significantincrease of ABI after therapeutic exercise walking in the treatment group (p= 0.001). However therewas a significant decrease of ABI between pretest and posttest in control group (p=0.010).Independent t-test indicated a significant difference of ABI between treatment group and controlgroup (p=0.000). So, it can be concluded that there is an influence of therapeutic exercise walking onthe peripheral blood circulation in patients with type 2 diabetes mellitus. Nurses should applytherapeutic exercise walking to improve peripheral blood circulation in patients with type 2 diabetesmellitus.Keywords: type 2 diabetes mellitus, therapeutic exercise walking, ankle brachial index
Operacionalização para Portugal da Lista EU(7)-PIM para Identificação de Medicamentos Potencialmente Inapropriados nos Idosos
Authors: Rodrigues Daniela A. , Herdeiro Maria T. , Thürmann Petra A. , Figueiras Adolfo , Coutinho Paula , Roque Fátima
Published: November 2020

Introdução: Em 2015 foi publicada a lista EU(7)-PIM, que identifica medicamentos potencialmente inapropriados na população idosa e resultou de um consenso de peritos de sete países europeus. Portugal não fez parte deste grupo, pelo que na sua origem não foi adaptada para a realidade portuguesa. Com este trabalho pretendemos elaborar uma lista de medicamentos potencialmente inapropriados adaptada à realidade dos medicamentos comercializados em Portugal, através da operacionalização da lista EU(7)-PIM para a realidade nacional, avaliar a adequabilidade do seu uso na prática clínica.Material e Métodos: Pesquisa, na base de dados Infomed do INFARMED, dos medicamentos incluídos na lista EU(7)-PIM que apresentam autorização de introdução no mercado, e análise de possíveis novos medicamentos para inclusão na lista. A ferramenta adaptada para a realidade Portuguesa foi aplicada a uma amostra de 1089 idosos polimedicados não institucionalizados, utentes de 38 unidades de cuidados de saúde primários da região centro.Resultados: A lista final adaptada para a realidade portuguesa inclui 184 medicamentos potencialmente inapropriados (dos quais 178 são substâncias ativas, cinco são classes de medicamentos e um corresponde ao esquema terapêutico sliding scale usado nas insulinas). Dos 1089 idosos polimedicados, 83,7% tomavam pelo menos um fármaco incluído na lista final de medicamentos potencialmente inapropriados ou pertencente a um dos grupos incluídos na lista e, em média, cada doente tomava 1,74 (IQR 1 – 2).Discussão: Apesar da disponibilidade de fármacos no mercado ser bastante diversa, a lista EU(7)-PIM tem sido utilizada em vários países europeus. Com este estudo operacionalizamos a lista europeia para a realidade portuguesa, facilitando assim a sua aplicação na prática clínica.Conclusão: A lista elaborada apresenta-se como uma ferramenta útil para a identificação de medicamentos potencialmente inapropriados, de fácil utilização na prática clínica e em investigação.
DESCRIPTION OF DEPRESSION SYMPTOMS IN HEMODIALYSIS PATIENTS AT JEMURSARI HOSPITAL, SURABAYA
Authors: Wulansari Yuyun Tri , Umbul W Chatarina
Published: November 2020

Chronic kidney disease is decreasing glomerular filtration rate of less than 15mL/minute which causes someone to undergo a hemodialysis therapy that replaces kidney function. The course of chronic kidney disease is progressive and irreversible and may cause psychological problems in hemodialysis patients such as depression. This study aimed to describe to what extent patients under hemodialysis treatment at Jemursari Hospital, Surabaya experience depression symptoms in patients. This study was descriptive research with a cross-sectional approach. The simple random sampling technique was performed to select 72 patients who had scheduled hemodialysis treatment and been qualified for the inclusion criteria. Data were then analyed using a univariate analysis in variable frequency distribution. The results show that patients with depression symptoms were mostly men as many as 31 people (43.1%), and the majority were aged 46-65 years as many as 24 people (49%).  The latest formal education in most respondents was high school (23.6%). There were 38 respondents (77.5%) who got married, and most respondents were unemployed (77.5%) and had undergone hemodialysis for more than 12 months (77.5%). This study concludes that the patients under hemodialysis treatment at the hospital experienced mild depression symptoms. Keyword: hemodialysis, depression, Beck Depression Inventory.
AN OVERVIEW OF DEPRESSION TENDENCIES IN PATIENTS WITH TYPE 2 DIABETES MELLITUS IN KEBONSARI PRIMARY HEALTHCARE CENTER, SURABAYA CITY
Authors: Shofiyati Iftitah
Published: November 2020

Type 2 diabetes mellitus (DM) occurs due to insufficient insulin production or insulin resistance in the human body. Type 2 DM also causes physical weakness, vision problems, risk of death, and depression. This study aimed to describe depression tendencies in patients with type 2 DM under treatment in Kebonsari Primary Healthcare Center, Surabaya city. This study was a descriptive study with a cross-sectional approach. The research samples were 74 people with type 2 DM in the Kebonsari Primary Healthcare Center, Surabaya city. These respondents selected using simple random sampling had met the inclusion criteria.  These repsondents were aged more than 25 years old, did not experience psychological disorders, and had suffered from type 2 diabetes mellitus for 5 years. The data analysis was done using a univariate analysis by looking at the  frequency distribution of variables. The results indicate that the prevalence of patients with type 2 DM who tended to experience depression was at 50%. The majority of patients with type 2 DM who experienced depression were women (47.4%) and elderly (aged 46-65 years) (41.9%). Most of them had low education levels (62.2%), and some respondents had complications (37.8%) and poor family support (62.2%). Support from closest people such as family support can improve the adaptation of patients with the disease and can prevent psychological disorders, especially depression in patients with type 2 DM.  Keyword: type 2 diabetes mellitus, family support, depression tendencies.
PENGARUH CLINICAL DIAGNOSIS TERHADAP KEBUTUHAN GYMNASIUM DI CIVITAS AKADEMIKA UNIVERSITAS AIRLANGGA SURABAYA
Authors: Lutfiana Ragilia Indah
Published: November 2020

Fitness center / gymnasium is one of the sports favored by the public because in the fitness center has a range of tools and facilities that have been designed so that it can be used as a tool for physical exercise that right. So the longer the gymnasium has also become a necessity for people, Necessity (need) here are divided into two categories, felt or perceived (subject assessment) and evaluated (clinical diagnosis).This study uses a quantitative approach. While the survey research techniques are activities taking samples from a population and using questionnaires as the main data collection tool to understand the needs of students related Airlangga University gymnasium. The results of the study that students need a gymnasium facilities are only accessible by only academy person and in which there is a pool and a cafeteria. This may indicate that students are given follow the advice of doctors to perform the sport swim and is in accordance with the desired exercise by students.
RECOMMENDATION OF DIPHTHERIA ANTITOXIN TO DIFFERENT SUSPECTS DURING THE DIPHTHERIA OUTBREAKS,LUMAJANG DISTRICT IN 2018
Authors: Arifin Munif
Published: November 2020

The number of diphtheria suspects in Lumajang district was the second highest in East Java province during the diphtheria outbreaks in 2018. The number of diphtheria cases was more than 500% in 2018 compared to 2017. To give diphtheria antitoxin (DAT), the provincial diphtheria expert team consider various suspects’ characteristics for DAT recommendation as DAT supplies are limited. This case report aimed to explore and describe the relationship between diphtheria suspects’ characteristics, including age, gender, symptoms, immunization status, duration of disease, and contact status with other suspects according to the  DAT recommendations from the expert team. This case report was descriptive and used a cross-sectional approach. It was conductedduring the diphtheria outbreaks and involved total samples of all suspects. Based on age, the majority of the suspects (92%)were under 19 years old. Suspects at this age were the target of an outbreak response immunization (ORI) program. Those who were not targetted to receive ORI (aged over 19 years) began to appear in November and mostly in December. The trend of non-ORI targetted age increased after the third round of ORI implementation. According to the report form parents, most suspects (46.7%) had complete immunization status, and only 6.7% of their immunization records were reported on growth chart cards. All suspects with positive diphtheria never had and know routine immunization records. The laboratory tests show only 5% were suspected with positive diphtheria with a cultural type of mitis toxigenic. As many as 32% of the total suspects were recommended for DAT treatment. The use of controlled DAT could save 1,640,000 iU. Keywords: Diphtheria, outbreak response immunization, diphtheria antitoxin.
Automatic Segmentation of White Matter Hyperintensities from Brain Magnetic Resonance Images in the Era of Deep Learning and Big Data – A Systematic Review
Authors: Balakrishnan Ramya , Valdes Hernandez Maria , Farrall Andrew
Published: November 2020

Background: White matter hyperintensities (WMH), of presumed vascular origin, are visible and quantifiable neuroradiological markers of brain parenchymal change. These changes may range from damage secondary to inflammation and other neurological conditions, through to healthy ageing. Fully automatic WMH quantification methods are promising, but still, traditional semi-automatic methods seem to be preferred in clinical research. We systematically reviewed the literature for fully automatic methods developed in the last five years, to assess what are considered state-of-the-art techniques, as well as trends in the analysis of WMH of presumed vascular origin. Method: We registered the systematic review protocol with the International Prospective Register of Systematic Reviews (PROSPERO), registration number - CRD42019132200. We conducted the search for fully automatic methods developed from 2015 to July 2020 on Medline, Science direct, IEE Explore, and Web of Science. We assessed risk of bias and applicability of the studies using QUADAS 2. Results: The search yielded 2327 papers after removing 104 duplicates. After screening titles, abstracts and full text, 37 were selected for detailed analysis. Of these, 16 proposed a supervised segmentation method, 10 proposed an unsupervised segmentation method, and 11 proposed a deep learning segmentation method. Average DSC values ranged from 0.538 to 0.91, being the highest value obtained from an unsupervised segmentation method. Only four studies validated their method in longitudinal samples, and eight performed an additional validation using clinical parameters. Only 8/37 studies made available their method in public repositories. Conclusions: We found no evidence that favours deep learning methods over the more established k-NN, linear regression and unsupervised methods in this task. Data and code availability, bias in study design and ground truth generation influence the wider validation and applicability of these methods in clinical research.
The Driving Force and Progressive Mechanisms of Evolution Deduced from Thermodynamics
Authors: Chen Ji-Ming
Published: November 2020

Studies on evolution have made significant progress in multiple disciplines, but evolutionary theories remain scattered and controversial. Here we deduce that, thermodynamically, many carbon-based entities (CBEs) on the Earth tend to absorb energy from widespread relatively temperate heat streams on the Earth flowing from the solar, geothermal, and other energy sources, to form higher-hierarchy CBEs (HHCBEs). This has been the driving force of evolution leading to accumulation of HHCBEs for billions of years. We further deduce three progressive mechanisms of evolution including natural selection from the driving force. We hence establish the CBE evolutionary theory (CBEET) which reinterprets the major aspects of evolution in a comprehensive and comprehensible way. The CBEET provides novel explanations for natural selection, origin of life (abiogenesis), macroevolution, sympatric speciation, and evolutionary tempos. It suggests that evolution is driven hierarchy-wise by thermodynamics and favors fitness and diversity. It elucidates that altruism, collaboration, and obeying rules with balanced freedom are important throughout the CBE evolution which includes chemical evolution, biological evolution, and animal group evolution. The CBEET refutes several erroneous views including negative entropy and survival of the fittest. It integrates with research advances in multiple disciplines and links up laws of physics, evolution in biology, and harmonious development of human society.
Assessment of Selected Clock Proteins (CLOCK, CRY1) and their Relationship with Biochemical, Anthropometric and Lifestyle Parameters in Hypertensive Patients
Authors: Mikulska Aniceta Ada , Grzelak Teresa , Pelczyńska Marta , Bogdański Paweł , Czyżewska Krystyna
Published: November 2020

Circadian rhythms misalignment is associated with hypertension. The aim of the study was to evaluate the concentration of selected clock proteins- cryptochrome 1 (CRY1) and circadian locomotor output cycles kaput (CLOCK) and to determine their relationships with biochemical and anthropometric parameters and lifestyle elements (diet, physical activity, quality of sleep) in hypertensive patients. In 25 female with hypertension (HT) and 49 non-hypertensive women (NHT), the CRY1 and CLOCK concentrations, total antioxidant status (TAS), lipid profile and glycemia were conducted. Blood pressure and anthropometric measurements, nutritional, exercise and sleep analyses were performed. In HT the CRY1 level was 40.2% lower than in the NHT. No differences were noted in CLOCK concentration between groups. The study showed no relationship between CRY1 or CLOCK concentrations and glucose or lipids profile, amount of physical activity and sleep quality, although CRY1 was associated with some anthropometric parameters. There was a negative correlation between the CLOCK concentration and the amount of saturated fatty acids consumed (24h) in HT. That indicates the possible influence of the diet on the CLOCK level. In a detailed prognosis of the risk of hypertension, it is worth considering the measurement of the level of CRY1 in populations with abnormal anthropometric indices.
Effect of the Strain Rate on Damage in Filled EPDM During Single and Cyclic Loadings
Authors: Candau Nicolas , Oguz Oguzhan , Peuvrel-Disdier Edith , Bouvard Jean-Luc , Maspoch María Lluïsa , Corvec Guillaume , Pradille Christophe , Billon Noëlle
Published: November 2020

The effect of the strain rate on damage in carbon black filled EPDM stretched during single and multiple uniaxial loading is investigated. This has been performed by analysing the stress-strain response, the evolution of damage by Digital Image Correlation (DIC), the associated dissipative heat source by InfraRed thermography (IR), and the chains network damage by swelling. The strain rates were selected to cover the transition from quasi-static to medium strain rate conditions. In single loading conditions, the increase of the strain rate yields in a preferential damage of the filler network while rubber network is preserved. Such damage is accompanied by a stress softening and an adiabatic heat source rise. Conversely, increasing the strain rate in cyclic loading conditions yields in a filler network accommodation and a high self-heating whose combined effect is proposed as a possible cause of the ability of filled EPDM to limit damage, by reducing cavities opening during loading and favoring cavities closing upon unloading.
Application of Machine Learning for the Automation of the Quality Control of Noise Filtering Processes in Seismic Data Imaging
Authors: mejri mohamed , Bekara Maiza
Published: November 2020

Seismic imaging is the main technology used for subsurface hydrocarbon prospection. It~provides an image of the subsurface using the same principles as ultrasound medical imaging. As for any data acquired through hydrophones (pressure sensors) and/or geophones (velocity/acceleration sensors), the raw seismic data are heavily contaminated with noise and unwanted reflections that need to be removed before further processing. Therefore, the noise attenuation is done at an early stage and often while acquiring the data. Quality control (QC) is mandatory to give confidence in the denoising process and to ensure that a costly data re-acquisition is not needed. QC is done manually by humans and comprises a major portion of the cost of a typical seismic processing project. It is therefore advantageous to automate this process to improve cost and efficiency. Here, we propose a supervised learning approach to build an automatic QC system. The~QC system is an attribute-based classifier that is trained to classify three types of filtering (mild = under filtering, noise remaining in the data; optimal = good filtering; harsh = over filtering, the signal is distorted). The attributes are computed from the data and represent geophysical and statistical measures of the quality of the filtering. The system is tested on a full-scale survey (9000 km2) to QC the results of the swell noise attenuation process in marine seismic data.
A Francisella tularensis Chitinase Contributes to Bacterial Persistence and Replication in Two Major U.S. Tick Vectors
Authors: Huntley Jason F. , Tully Brenden
Published: November 2020

Tick-borne tularemia was first described in 1924. Nearly 100 years later, questions remain about the tick vector(s) that pose(s) the greatest risk for transmitting Francisella tularensis (Ft), the causative agent of tularemia. Additionally, few studies have identified genes/proteins required for Ft to infect, persist, and replicate in ticks. To answer questions about vector competence and Ft transmission by ticks, we infected Dermacentor variabilis (Dv), Amblyomma americanum (Aa), and Haemaphysalis longicornis (Hl; invasive species from Asia) ticks with Ft, finding that although Aa ticks initially become infected with 1-log higher Ft, Ft replicated more robustly in Dv ticks, and did not persist in Hl ticks. In transmission studies, both Dv and Aa ticks efficiently infected naïve mice, causing disease in 57% and 46% of those mice, respectively. We identified a putative Ft chitinase, FTL1793, generated a FTL1793 mutant, and found that FTL1793 was deficient in tick infection, persistence, and replication in ticks. Recombinant FTL1793 exhibited chitinase activity in vitro, suggesting that this chitinase may provide an alternative energy source for Ft in ticks. Taken together, Dv ticks appear to pose a greater risk for harboring and transmitting tularemia and FTL1793 plays a major role in promoting tick infections by Ft.
Seasonal and Ephemeral Snowpacks of the Conterminous United States
Authors: Hatchett Benjamin
Published: November 2020

Snowpack seasonality in the conterminous United States (U.S.) is explored using a daily,14 km horizontal resolution gridded snow water equivalent and snow depth reanalysis product. I2calculated seasonal snowpacks using two established methods: (1) the classic Sturm approach that3requires 60 days of snow cover with a peak depth >50 cm and (2) the snow seasonality metric (SSM)4that only requires 60 days of continuous snow cover. The latter approach yields continuous values5from -1 to +1, where -1 (+1) indicates an ephemeral (seasonal) snowpack. Both approaches identify6seasonal snowpacks in western mountains and the northernmost central and eastern U.S. By relaxing7the depth constraint and providing continuous values, the SSM identifies greater areas of seasonal8snowpacks compared to the Sturm method, particularly in the upper Midwest, New England, and the9Intermountain West. Ephemeral snowpacks are identified throughout lower elevation regions of the10western U.S. and across a broad swath centered near 35°N spanning the lee of the Rocky Mountains11to the Atlantic coast. Because it lacks a depth constraint, the SSM approach is sensitive to interannual12variability, indicating it may inform the location of shallow but long-duration snowpacks at risk13of transitioning to becoming ephemeral with climatic change. A case study in Oregon during an14extreme snow drought year highlights seasonal to ephemeral snowpack transitions.
Role of Transposable Elements in Gene Regulation in the Human Genome
Authors: Ali Arsala , Han Kyudong , Liang Ping
Published: November 2020

Transposable elements (TEs), also known as mobile elements (MEs), are interspersed repeats that constitute a major fraction of the genomes of higher organisms. As one of their important functional impacts on gene function and genome evolution, TEs participate in regulating the expression of genes nearby and even far away at transcriptional and post-transcriptional levels. There are two principal ways by which TEs regulate expression of genes in the human genome. First, TEs provide cis-regulatory sequences in the genome. TEs’ intrinsic regulatory properties for their own expression make them potential factors for regulating the expression of the host genes. TE-derived cis-regulatory sites are found in promoter and enhancer elements, providing binding sites for a wide range of trans-acting factors. Second, TEs encode for regulatory RNAs. TEs sequences have been revealed to be present in a substantial fraction of miRNAs and long non-coding RNAs (lncRNAs), indicating their TE origin. Furthermore, TEs sequences were found to be critical for regulatory functions of these RNAs including binding to the target mRNA. TEs thus provide crucial regulatory roles by being part of cis-regulatory and regulatory RNA sequences. Moreover, both TE-derived cis-regulatory sequences and TE-derived regulatory RNAs, have been implicated to provide evolutionary novelty to gene regulation. These TE-derived regulatory mechanisms also tend to function in tissue-specific fashion. In this review, we aim to comprehensively cover the studies regarding these two aspects of TE-mediated gene regulation, mainly focusing on the mechanisms, contribution of different types of TEs, differential roles among tissue types, and lineage specificity, based on data mostly in humans.
Topology Optimization of Microstructures to Reduce Structural Oscillations
Authors: Zymvragakis Georgios Stylianos , Koutsianitis Panagiotis , Stavroulakis Georgios E.
Published: November 2020

Vibration suppression in a field of frequencies and the creation of band gaps which do not allow the propagation of the waves is studied in this paper by means of microstructures designed through topology optimization. Topology optimization is formulated in frequency domain. Band gap design is based on Floquet-Bloch theory and genetic optimization. The result is appealing in view of modern 3D printing techniques.
A Reduced-Size Microstrip Four Poles Hairpin Band-Pass Filter with Multilayer Parallel-Coupled Line for Satellite Broadcasting
Authors: Tarbosh Qazwan Abdullah , Mohd Shah Nor Shahida , Pandey Bishwajeet , Salh Adeeb , Farah Nabil , Aboali Majed , Mohamad Mahathir , Inam Abbasi Muhammad , Saif Abduh
Published: November 2020

Recently, a multilayer structure is very imperative to minimize the size of planar microstrip filters. In the flexible design and incorporation of other microwave components, a multilayer band-pass filter provides another dimension. This paper, therefore, introduces a band-pass filter of 2.52-2.65 GHz for digital broadcast applications using parallel-coupled line (PCL) and multilayer(ML) hairpin resonator. The targeted four-pole resonator has a center frequency of 2.58 GHz with a bandwidth of 130 MHz. The hairpin-line offers compact filter design structures. The proposed configuration of the parallel-coupled line (PCL) resonator is used to design the ML band-pass filter. The FR4 substrate with a dielectric constant (εr) of 4.3 and 1.6 mm thickness was used. Comparison analysis between the simulated insertion loss and the reflection coefficient of substrates RO3003 and FR4 was performed to verify the efficiency of the proposed filter design. Simulation of PCL filter is accomplished using computer simulation technology (CST)and an advanced design system(ADS). The PCL bandpass filter was experimentally validated and good agreement between simulation and measured results were achieved showing a well-measured reflection coefficient. The simulated results of the ML bandpass filter show that the circuit performs well, and the filter size is significantly reduced.
CECILIA BÖHL DE FABER ANTES DE FERNÁN CABALLERO. La emergencia de una identidad y una voz autoriales
Authors: Botteron Julie
Published: November 2020

Cecilia Böhl de Faber (1796-1877) tuvo afición a la escritura desde muy joven: sus primeros pasos literarios ya se observan en las décadas iniciales del siglo XIX. En el artículo se examina cómo emerge su identidad autorial, cómo se expresa mediante su voz autorial y cómo representa al sujeto femenino, en una selección de las primeras creaciones de la autora publicadas por Camille Pitollet a inicios del siglo XX. Por consiguiente, se argumenta que la carrera literaria de la escritora comienza antes de su elección del seudónimo Fernán Caballero y su decisión de publicar sus obras como La gaviota en 1849.
LAS LETTERS DE JOHN TALBOT DILLON (1781) Y EL ESSAI SUR LA LITTÉRATURE ESPAGNOLE (1810) EN LOS INICIOS DE LA HISTORIOGRAFÍA LITERARIA ESPAÑOLA
Authors: Contreras Jiménez Manuel
Published: November 2020

Thomasina Ross advertía ya en 1823 que el Essai sur la littérature espagnole (1810), era un «gross plagiarism» de las Letters from an English traveller… (1781) de John Talbot Dillon. El presente artículo analiza la relación textual entre ambas obras, enmarcándolas en los orígenes de la historiografía literaria española. A través de una exploración de las diversas fuentes nacionales (en especial los Orígenes de Velázquez, 1754) y extranjeras utilizadas por Dillon y el autor del Essai, también se ofrecen conclusiones al respecto de: 1) cómo nacen y evolucionan las primeras historias de la literatura española en un constante diálogo que superó nuestras fronteras; 2) cómo a principios del XIX la imagen de España y su literatura vive un importante cambio en el que destacaron los viajeros británicos desde el último tercio del siglo XVIII, y el propio Dillon en particular.
Musa, refugio y pesadilla de poetas: la gran ciudad en la década expresionista alemana
Authors: Riesco Chueca Pascual
Published: November 2020

Ignorada por la poesía esteticista de fin de siglo, la gran ciudad irrumpe como tema literario para la lengua alemana hacia 1910. Berlín y Viena, grandes babilonias de placer y apocalipsis, nutren una riquísima producción. Ante los insólitos paisajes de la tecnología y la masificación, se exploran nuevos estilos, en particular, los ritmos sincopados y la yuxtaposición de imágenes atrevidas e inesperadas, a modo de collage. En estas páginas se ofrece una selección de autores de la etapa expresionista, escogidos entre los menos familiares para el público español; en su práctica totalidad se trata de poemas no traducidos previamente al castellano. Ignored by the aestheticist poets of the turn of the century, the great city suddenly grows into a literary theme in Germany around 1910. Berlin and Vienna, great Babylonian metropoles of pleasure and apocalypse, deliver an overwhelming production. Against the backdrop of unprecedented landscapes, built out of technology and overcrowding, new styles are explored, in particular, the syncopated rhythms and the juxtaposition of daring and unexpected collage-like images. In the following we offer a selection of authors from the expressionist years, chosen from among the least familiar to the Spanish public. Nearly all the poems included have no previous translation into Spanish.
Cristina Jiménez Gómez, Construcción de los personajes femeninos galdosianos desde una perspectiva de mujer
Authors: Gago Gómez Liliana
Published: November 2020

Reseña de Libro
Sagittal alignment changes and postoperative complications following surgery for adult spinal deformity in patients with Parkinson’s disease: a multi-institutional retrospective cohort study
Authors: Kawabata Atsuyuki , Yoshii Toshitaka , Sakai Kenichiro , Hirai Takashi , Yuasa Masato , Inose Hiroyuki , Matsukura Yu , Morishita Shingo , Tomori Masaki , Torigoe Ichiro , Kusano Kazuo , Otani Kazuyuki , Arai Yoshiyasu , Shindo Shigeo , Okawa Atsushi
Published: November 2020

Background: Parkinson’s disease (PD) has been reported to increase the risk of postoperative complications in patients with adult spinal deformity (ASD). However, those studies are limited, and few have made direct comparisons with patients who do not have PD.Methods: A retrospective cohort study. We retrospectively reviewed all surgically treated ASD patients with at least a 2-year follow-up. Among them, 27 had PD (PD(+) group). Clinical data were collected on early and late postoperative complications as well as any revision surgery. Radiographic parameters were evaluated before and immediately after surgery and at final follow-up, including sagittal vertical axis (SVA), thoracic kyphosis, lumbar lordosis, sacral slope, and pelvic tilt. We compared the surgical outcomes and radiographic parameters of PD patients with those of non-PD patients.Results: For early complications, the PD(+) group demonstrated a higher rate of delirium than the PD(−) group. With regard to late complications, the rate of radiological pseudarthrosis was significantly higher in the PD(+) group. Rates of rod failure and revision surgery due to mechanical complications also tended to be higher, but not significantly, in the PD(+) group (p = 0.17, p = 0.13, respectively). SVA at final follow-up and loss of correction in SVA were significantly higher in the PD(+) group.Conclusion: Extra attention should be paid to perioperative complications, especially delirium, in PD patients undergoing surgery for ASD. Furthermore, loss of correction and rate of radiological pseudarthrosis were greater in these patients.
Pursue today and assess tomorrow - how students’ subjective perceptions influence their preference for self- and peer assessments
Authors: Melser Meskuere Capan , Lettner Stefan , Bäwert Andjela , Puttinger Claudia , Holzinger Anita
Published: November 2020

Background: Alternative assessments engage students in the assessment process to improve both short- and long-term outcomes by developing their judgments and responsibility about their own learning, and that of their peers. In this study, we investigated students’ perception towards self- and peer-assessment, their objectivity and impact on students’ learning. Methods: The study was conducted at the Medical University of Vienna. Attitudes of second year undergraduate medical students towards self- and peer-assessment, and their objectivity, appropriateness, and the impact of these assessments on students’ learning activities, was inquired using a self-developed questionnaire. Results: 423 students participated in this study. Self-assessment was found more appropriate method to assess students’ knowledge. Most of students agreed that peer-assessment is not objective (M= -0.07). Majority of students evaluated that peer assessment has no or little impact on their active and passive learning (M= -0.23, -0.35), on the other hand self-assessment was reported as a helpful tool for gaining long-term knowledge (M= 0.13) and following the content of courses (M= 0.16). Conclusion: Based on our results, students’ perspective on peer assessment were negative, on the whole, students had positive attitudes towards self-assessment and negative attitudes towards peer-assessment. This study also determined that self-assessment leads to the promotion of students’ learning.
A Novel Anatomical Locking Plate Combined With an Anterior Column Screw and Magic Screw for Acetabular Fractures Involving Both Columns: Reduction Effect and Functional Outcomes
Authors: Zhang Gongzi , Zhang Shuwei , Sui Yi , Wang Xiang , Su Xiuyun , Cao Zuo , Luo Shijie , Tang Peifu , zhang Lihai
Published: November 2020

BackgroundA novel anatomical locking plate (NALP) was designed. The NALP is fixed via an anterior column screw and a Magic screw to apply pressure on the acetabular fracture ends. This study was performed to compare the reduction effect and clinical outcome of the NALP versus the anatomical locking plate (ALP) for acetabular fractures involving both columns.MethodsFrom January 2013 to January 2018, 22 patients with acetabular fractures involving both columns were treated using the NALP or ALP in a single institution. The general condition and type of fracture were recorded. The NALP and ALP groups were compared regarding the Letournel fracture classification, operative approach, time from injury to operation, intraoperative bleeding volume, and operation time. The radiographic reduction outcome and hip function at final follow-up were compared between the two groups based on the Matta scores and Harris hip scores, respectively.ResultsThe NALP was used in 10 patients, while the ALP was used in 12. Three patients had transverse fractures, 12 had transverse fractures involving posterior wall, and 7 had double-column fractures. The two groups had no significantly differ regarding sex, age, affected side, Letournel fracture classification, operative approach, or follow-up duration. The time from injury to the operation was 20.70±1.2 days in the NALP group and 13.17±7.5 days in the ALP group (p=0.089). The operation time was 332.20±128.9 minutes in the NALP group and 257.50±91.6 minutes in the ALP group (p=0.128). The intraoperative blood loss volume was 1550.00±869.5 ml in the NALP group and 666.67±370.1 ml in the ALP group (p=0.011). The Matta score at final follow-up was 1.10±0.8 in the NALP group and 2.46±1.9 in the ALP group (p=0.045). The Harris hip score at final follow-up was 87.50±10.5 in the NALP group and 81.00±10.1 in the ALP group (p=0.0782).ConclusionThe NALP achieves adequate compression of the acetabular fracture ends and obtains stronger fixation than the ALP.Trial registrationChiCTR,ChiCTR2000030825. Registered 15 March 2020 - Retrospectively registered, http://www.chictr.org.cn/ChiCTR2000030825
An Open Label, Randomised Controlled Trial of Rifapentine Versus Rifampicin Based Short Course Regimens for the Treatment of Latent Tuberculosis in England: The HALT LTBI Pilot Study
Authors: Surey Julian , Stagg Helen R , Yates Thomas A , Lipman Marc , White Peter J , Charlett Andre , Muñoz Laura , Gosce Lara , Rangaka Molebogeng X , Francis Marie , Hack Vanessa , Kunst Heinke , Abubakar Ibrahim
Published: November 2020

BackgroundEnding the global tuberculosis (TB) epidemic requires a focus on treating individuals with latent TB infection (LTBI) to prevent future cases. Promising trials of shorter regimens have shown them to be effective as preventative TB treatment, however there is a paucity of data on self-administered treatment completion rates. This pilot trial assessed treatment completion, adherence, safety and the feasibility of treating LTBI in the UK using a weekly rifapentine and isoniazid regimen versus daily rifampicin and isoniazid, both self-administered for twelve weeks. MethodsAn open label, randomised, multi-site pilot trial was conducted in London, UK, between March 2015 and January 2017. Adults between 16 and 65 years with LTBI at two TB clinics who were eligible for and agreed to preventative therapy were consented and randomised 1:1 to receive either a weekly combination of rifapentine/isoniazid (‘intervention’) or a daily combination of rifampicin/isoniazid (‘standard’), with both regimens taken for twelve weeks; treatment was self-administered in both arms. The primary outcome, completion of treatment, was self-reported, defined as taking more than 90% of prescribed doses and corroborated by pill counts and urine testing. Adverse events were recorded. Results52 patients were successfully enrolled. In the intervention arm 21 of 27 patients completed treatment (77.8%, 95% confidence interval [CI] 57.7-91.4), compared with 19 of 25 (76.0%, CI 54.9-90.6) in the standard of care arm. There was a similar adverse effect profile between the two arms. ConclusionIn this pilot trial, treatment completion was comparable between the weekly rifapentine/isoniazid and the daily rifampicin/isoniazid regimens. Additionally, the adverse event profile was similar between the two arms. We conclude that it is safe and feasible to undertake a fully powered trial to determine whether self-administered weekly treatment is superior/non-inferior compared to current treatment.Trial RegistrationThe trial was funded by the NIHR, UK and registered with ISRCTN (26/02/2013-No.04379941).
Pyroptosis Related Molecules are Significant for Cartilage Degeneration
Authors: Jia Mengying , Lv Yaoguang , Xu Yingjie , Gong Zhoncheng
Published: November 2020

Background: Pyroptosis is the highlight topic in inflammation. However, there is rarely research on relationship between pyroptosis and temporomandibular joint osteoarthritis (TMJOA), The aim of this study is to explore whether pyroptosis related molecules are significant for condylar cartilage degeneration and to verify the clinical effects of sodium hyaluronic acid (HA) treatment on TMJOA.Methods: Patients diagnosed as temporomandibular joint internal derangement (TMJID) without condylar defect and TMJOA with condylar defect were divided into two groups. Thirty patients in each group, and they were tested for pyroptosis related molecules via synovial fluid included interleukin-1beta (IL-1β), IL-18, nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3 (NLRP3), cysteinyl aspartate specific proteinase 1 (CASP1) with Enzyme-linked immunosorbent assay（Elisa）. Eighteen cases in TMJOA group were tested again after twice HA treatment to evaluate HA’s therapeutic effects. Results: IL-1β, IL-18, NLRP3 and CASP1 were all positive in two groups, TMJOA patients with condylar defect had higher expressions of above molecules compared with TMJID patients (P＜0.05). IL-1β, IL-18, NLRP3 were decreased with twice HA therapy (P＜0.05), there was no significant difference in CASP1 with twice HA injections (P=0.549). Conclusions: Cell pyroptosis may be involved in condylar degeneration. HA could reduce part of pyroptosis molecules to relieve inflammation.
Time Series Analysis of Hemorrhagic Fever with Renal Syndrome in Mainland China by using XGBoost Forecasting Model
Authors: Lv Cai-Xia , An Shu-Yi , Qiao Bao-Jun , Wu Wei
Published: November 2020

Background: Hemorrhagic fever with renal syndrome is still attracting public attention because of its outbreak in various cities in China. It is one of the effective preventive measures to predict the peak incidence rate in the future based on the past incidence data, and implement targeted actions. In this study, we propose a multi-step prediction strategy based on XGBoost for hemorrhagic fever with renal syndrome as an extension of the one-step prediction model. Moreover, the fitting and prediction accuracy of XGBoost model will be compared with seasonal ARIMA model by different evaluation indicators. Methods: We collected monthly hemorrhagic fever with renal syndrome incidence data from 2004 to 2018 in mainland China .The part from 2004 to 2017 was divided as training set to establish the seasonal ARIMA model and XGBoost model. The rest 2018 data was used to test the prediction outcomes. In multi-step forecasting XGBoost model, one-hot encoding was used to handle seasonal features. Furthermore, series of evaluation index(MAE,MPE,MAPE,RMSE,MASE, ACF1, Theil’s U) were performed to evaluate the accuracy of multi-step forecast XGBoost model.Results: There were totally 200237 HFRS cases in China from 2004 to 2018. A slightly long-term downward trend and obvious bimodal peak seasonal character were identified in the original time series. According to the minimum CAIC value, the optimal ARIMA (3,1,0) × (1,1,0)12 model is selected. the ME , MAE, MPE, MAPE, MASE of XGBoost were higher than ARIMA model in the fitting part, whereas the RMSE of XGBoost was lower. The evaluation indicators (MAE, MPE, MAPE, RMSE , MASE) of the one-step prediction and multi-step prediction XGBoost model are all notably lower than the ARIMA model in prediction performance. Conclusions: The multi-step prediction XGBoost model showed a much better prediction accuracy and model stability in HFRS disease . In general, compared to the seasonal ARIMA model, the XGBoost model performs better when predicting complicated and non-linear data like Hemorrhagic fever with renal syndrome. Additionally Multi-step prediction models are more practical than one-step prediction in forecasting infectious diseases.
Suspension Sutures Facilitate Single Incision Laparoscopic-Assisted Rectal Pull-Through for Hirschsprung Disease
Authors: Nguyen Liem Thanh , Tho Anh Nguyen , Thanh Quang Nguyen , Anh Quynh Tran , Duc Hau Bui , Duy Hien Pham
Published: November 2020

BackgroundTo present the surgical technique and long-term follow-up outcomes of single incision laparoscopic-assisted endorectal pull-through (SILEP) with suspension sutures using conventional instruments for Hirschsprung disease. MethodsThe procedure began with a 1cm transumbilical skin incision. Three separate punctures were made onto the fascia for a 5mm scope in the middle, a 5mm and 3mm ports for working instruments on the left and right, respectively. The first suspension suture was performed to secure the sigmoid colon to the abdominal wall. A window was created through the rectal mesentery, and dissection around the rectum was carried out. The second suspension suture was performed to suspense the rectovesical peritoneal fold or the rectovaginal peritoneal fold to the abdominal wall. Dissection around the rectum was continued downward to approximately 1cm below the peritoneal fold. The operation was completed by a transanal approach. Results40 patients underwent SILEP from March 2013 to April 2015. The median age was 2.7 months (ranged from 14 days to17 months). The mean operative time was 94.7 ± 20 minutes. No conversion to open operation was required. Mean hospital stay was 4.1±1.3 days. There were no intraoperative or perioperative complications. Long term follow-up results were obtained in 38 patients. The number of defecation from 1-2 times per day was noted in 36 patients (94.7%) and from 3-4 times per day in 2 patients (5.2%). Two patients had enterocolitis (5.2%).ConclusionSingle site laparoscopic rectal pull-through with suspension sutures using conventional instruments is feasible and safe for Hirschsprung disease with good long-term outcomes.