bluuebunny/crossref_metadata_2025 huggingface dataset:
Consumer Value Perception Model as Consideration for Fusion Beverage Business Sustainability
Authors: Hamdan Hamdan , Raharja Indra , Ilhamalimy Ridho Rafqi , Ali Hapzi
Published: February 2023

This research is about consumers’ perception of value in deciding to consume fusion drinks. Fusion drink is a drink that combines various basic ingredients, such as coffee, sugar, milk, tea, cheese, chocolate, yakult and various other basic ingredients. Perceived value arises when consumers decide to consume fusion drinks. This is because, the value contained when consuming fusion drinks is to get pleasure and happiness from various flavors and aromas, where the benefits obtained from various services and offers, as well as the image of the outlet also provide added value. This study seeks to determine the effect of perceived utility, perceived variation, perceived outlet image, perceived hedonic, and perceived value used to build the research model, by conducting an online survey of how these factors are related. The findings of this study are the perceived utility, perceived variation, perceived outlet image, perceived hedonic, and perceived value have a real relationship in shaping positive attitudes and behavior of consumers in deciding to consume fusion drinks.
Marketing Risk Management and Mapping Based on Geographic Information System in The Micro, Small, and Medium Enterprise in Tasikmalaya City
Authors: Maesaroh Syti Sarah , Swardana Ardli , Nuryadin Asep , Herdiana Oding , Rahatuningtyas Risma
Published: February 2023

The current COVID-19 pandemic has greatly impacted the economic sector, especially Micro, Small, and Medium Enterprises (MSMEs). Restrictions on physical mobility hinder the marketing of MSMEs’ products, which is usually carried out directly. This is one of the important risks to be studied in depth. The purpose of this study is to determine the management system and mapping of marketing risks in MSMEs in Tasikmalaya City. The research method used in this study was descriptive quantitative. Data were collected through a closed questionnaire that was given to MSMEs. The obtained data were processed through a risk management system approach and then mapped using a Geographical Information System (GIS). The results showed that the highest marketing risks for MSMEs in Tasikmalaya City are increasingly fierce business competition, nonoptimal internet usage, and limited marketing coverage. Geographically, the level of marketing risks of MSMEs in Tasikmalaya City is in the medium category. Geographical marketing risk mapping can determine the most appropriate recommendations to deal with various risks faced according to regional characteristics.
Care About The Way You Look? Website Quality Impact on Purchase Decision Mediated by Ewom and Ease of Use
Authors: Jokhu Jean Richard
Published: February 2023

In the forthcoming industry of technology, many people look for websites to purchase things online. When people moving to smartphone app there are several app still uses website for their main transaction. One of the benefit of using website is easy to access with smartphone, tablet, laptop, or personal computer. In this research, we try to look for the effect of website quality on a purchase decision in a marketplace and the effect of ease of use and electronic word of mouth as the mediating effect of website on purchase decision. Website quality is examined with the mediating variable as the amplifier toward a purchase decision. An online survey was used to collect respondents (300 valid responses) and PLS was used to analyze the relationship in the structural model. Results suggest that website quality if important in a purchase decision. Second, ease of use and EWOM amplify the effect of website quality on purchase decisions. With excellence website interface and positive online review about the website will increase customer transaction on e-commerce website.
The Effects Of Career Development, Organizational Climate, and Leadership Style on Employee Satisfaction
Authors: Antoro Yogi Yuli , Herminingsih Anik
Published: February 2023

Job satisfaction is an important thing in human resource management, because it will affect the positive behaviors of the employees.This study aims to examine and analyze the effect of career development, organizational climate and leadership style on employee job satisfaction. Population in this research is 120 employees of PT. Astra International Tbk. Auto 2000 Puri Kembangan. The sample used is 93 employees, calculated based on the Slovin formula. The Methods of data collection using survey methods, with the research instrument is a questionnaire. The data analysis method using Partial Least Square (PLS). The results of this study indicate that the career development variable has a positive and significant effect on job satisfaction. Organizational climate variable has a positive and significant effect on job satisfaction. And the leadership style variable has a positive and significant effect on job satisfaction.
Effect of Self Efficacy, Training, Motivation, and Competence on Organizational Commitment with Employee Performance as Intervening Variables at PT Bina Utama Sakti
Authors: Qurotalain Tukfa , Sriyono Sriyono , Fitriyah Hadiah
Published: February 2023

The problem on this research is that there may be a lower overall performance at PT Inkasa Jaya Aluminium which is due to the shortage of advantageous factors which include self-efficacy, training, motivation, and competence of PT Bina Utama Sakti personnel whose work at PT Inkasa Jaya Aluminium influences the decline in organizational dedication and worker overall performance.Objective: To investigate the impact of self-efficacy, training, motivation, and competence on organizational dedication with worker overall performance as an intervening variable.Methodology: Based on the approach of facts collection, the researcher used quantitative studies techniques with surveys. The number of samples in this study was 100 employees of the production division at PT Bina Utama Sakti. The data analysis method in this study is using SEM analysis with mediating effects using the SmartPLS3 application to determine P-values and Path Coefficient Test as hypothesis testing.Finding: The effects that are looked at are: Self-efficacy, motivation, and competence that don’t have any great and insignificant impact on organizational dedication; Training has a great and huge impact on organizational dedication; Self-efficacy, training, and motivation don’t have any great and insignificant impact on worker overall performance; Competence has a great and huge impact on worker overall performance; Employee overall performance has a great and huge impact on organizational dedication; Self-efficacy, training, motivation, and competence can't have an impact on organizational dedication via worker overall performanceConclusion: To optimize performance, the company should make a special policy to be able to further improve the self-efficacy, training, motivation, and competence of their employees to maximize their performance in increasing the company's success in achieving its goals.Keywords: Competence;Employee Performance; Motivation; Organizational Commitment; Self-Efficacy
Capacity Building in Indonesian Banking Sector: A Review on Sustainable Financial Affairs
Authors: Christina Lenny , Siswanti Indra , Hidayat Ahmad , Maharini Maharini , Darwin Darwin
Published: February 2023

The implementation of sustainable finance is still a challenge in the banking sector. One important element is the availability of Human Resources who understand the sustainable economy. Banking institutions need to prepare professional and quality Human Resources who are able to apply the principles of sustainable finance so that they can create products or services in an effort to improve services to customers in the banking sector.Objectives: To support the Indonesian government's program for implementing sustainable financial programs, especially in the banking sector of Indonesia, a good strategy is needed to prepare and increase capacity building. The purpose of this research is to analyze the effect of Capacity Building in the implementation of Sustainable Finance in the banking sector of Indonesia.Methodology: This study used quantitative methods with 100 employees at banking institutions as the object of research. The research sampling technique uses simple random sampling with data analysis using SEM PLS.Finding: This research proves that leadership and talent management affect capacity building in the Banking sector towards implementing sustainable finance. This study proved that:1) direct influence of leadership talent management and capacity building to financial sustainability, 2) indirect influence of leadership and talent management on financial sustainability through capacity building.Conclusion: This research proves the influence of leadership and talent management on financial sustainability mediated by capacity buildingKeywords: Banking, Strategy, Capacity Building, Financial Sustainability.
The Impact of COVID-19 Pandemic on Homestays and Optimism in Kepulauan Seribu on Tourism Future through Smart Tourism
Authors: Ismail Ervan , Sumardjo Sumardjo , P. Lubis Djuara , A. Kinseng Rilus
Published: February 2023

Tourism stakeholders must seek out innovative tactics to survive and thrive in the face of adversity. Switching to digital media and developing new digital inventions is thought to be the best option (Heliany, 2019; Irwan & Novianti, 2021). Based on this, we consider it important to see the impact of the COVID-19 pandemic on Kepulauan Seribu tourism and its relation to digital communication as an effort to minimize the impact of the pandemic which aims to see the optimism of homestay owners. This article provides an overview of the COVID-19 pandemic impact on tourism business owners of homestays in Kepulauan Seribu until 2021Objectives: This article provides an overview of the COVID-19 pandemic impact on tourism business owners of homestays in Kepulauan Seribu until 2021. This study aims to measure the awareness level of health protocols and the decline in income for homestay owners. This study also aims to describe the future recovery opportunities through the readiness of digital communication towards smart-tourism in Kepulauan Seribu and the optimism of homestay owners in developing their homestays in the future.Methodology: This study uses a quantitative descriptive approach. The collection of questionnaire data uses cluster sampling starting on June 23, 2021 until October 7, 2021 with a total of 308 respondents based on collected questionnaires. The study was carried out on 9 islands during the COVID-19 pandemic and under the policy of Restrictions towards Community Activities (abbreviated to PPKM) by Indonesia’s government. The presentation of descriptive data analysis uses SPSS Version 24. To strengthen the analysis, in-depth interviews were carried out with key informants.Finding: The results of data analysis show a 60% decrease in homestay income and the number of tourists during the COVID-19 pandemic. The biggest use of digital marketing is for imaging activity, followed by digital transaction activity, marketing, and receiving criticism and suggestions as only less than 50% of homestay owners have attended training. Although affected by the COVID-19 pandemic, homestay owners are optimistic to continue to develop the capacity of their homestay in the future.Conclusion: The availability of infrastructure to support smart tourism is sufficient. The readiness of human resources in the form of skills in maximizing the use of digital communication for tourism still needs to be supported through continuous digital communication training programs and assistance by tourism-aware groups. Keywords: COVID-19 pandemic; digital communication; Kepulauan Seribu; smart-tourism
The Effect of Authentic Leadership and Work Engagement on Job Performance: Evidence from DKI Jakarta Provincial Government
Authors: Asda Sri Ramadhani , Nilasari B. Medina
Published: February 2023

Human Resources plays an important role in Government agencies. The Provincial Government of DKI Jakarta is trying to improve the knowledge and talents of employees with budget funds allocated for training, development, and significant improvements in both the administration and service fields to maximize the performance of Civil Servants.Objective: This study aims to analyze the effect of authentic leadership and work engagement on job performance, and High Performance Human Resource (HPHR) practices as variables that mediate the relationship between authentic leadership and work engagement on job performance.Methodology: The method used in this study is a quantitative method, using survey research with employees of the DKI Jakarta Provincial Government as the object of research. Data collection which was used is the cross-sectional method by distributing questionnaires. The research sample was selected using the purposive sampling method in order to obtain 205 respondents. The data analysis method used was Structural Equation Modeling (SEM) with AMOS 21 software. Results from the previous study were considered by adding work engagement variables in determining strategies to improve job performance.Findings: The results of this study provide information on authentic leadership participation, it will improve job performance and HPHR Practices, as well as increase an employee's attachment to work, also the more HPHR Practices and job performance will increase in the organization.Conclusion: Structuralists are expected to improve authentic leadership, especially from an internalized moral perspective, to produce ethical and transparent behavior. Civil servants need to increase work engagement, especially in the absorption aspect where employees need to concentrate fully when working in the office, develop deep interest, and willingness so that they feel bound to their work. To achieve this, a positive work environment is needed. As a result, employees feel comfortable, safe, and enthusiastic when working.
Do Overconfidence and Herding Affect Stock Investment Decision? Indonesian Cases During Pandemic Covid-19
Authors: Tamara Dewi
Published: February 2023

Objective: To analyze the effect of overconfidence and herding on stock investment decision-making with risk perception as a mediating variable and financial literacy as a moderating variable.Methodology: The survey was launched and replied by 99 stock investors. The data is analyzed using Structural Equation Modeling with the software Smartpls 3.0.Findings: The results show that herding had a positive and significant effect on stock investment decisions. Overconfidence does not have either a direct or indirect effect on stock investment decisions. Risk perception also does not mediate overconfidence in stock investment decisions. The Herding variable has an effect on stock investment decisions. However, financial literacy does not moderate herding and stock investment decisions. This research contributes in several ways. Firstly, overconfidence is not proven to indirectly affect stock investment decisions through risk perception. In other words, risk perception does not have a mediation effect.  Overconfidence also does not affect stock investment decisions directly.  Secondly, herding affects stock investment decisions positively. Finally, financial literacy does not moderate herding and stock investment decisions.Conclusion: The result showed that there was a significant positive effect of herding on stock investment decisions. Risk perception does not mediate overconfidence and stock investment decisions. Financial literacy does not moderate herding and stock investment decisions. Overconfidence also does not have a relation to stock investment position. In this research, the stock investment decision is mostly influenced by herding.
CEO employment contract heterogeneity and acquirer risk-taking
Authors: Zhao Jing
Published: February 2023

This study analyses a hand-collected, unique dataset on chief executive officer (CEO) employment contract details for S&P 500 companies over the period of 1993–2005. To control for the sample selection issue associated with firms granting a CEO contract, the study estimates the Heckman Selection model. The study finds substantial heterogeneity in contract provisions and their impact on acquirer risk-taking in mergers and acquisitions (M&As). More specifically, contract provisions that provide job and compensation security and equity incentives appear to encourage valuable risk-taking. In contrast, bureaucratic type provisions (automatic contract renewals; lack of equity incentives) motivate risky but value-decreasing deals. Further, more refined definitions of just cause for dismissal enhance valuable risk-taking, possibly by reducing contract ambiguities and the resulting disputes, whereas just causes based upon personal conduct reduce valuable risk-taking. This paper shows how heterogeneous contract provisions reflect the optimal contracting process in a competitive market for CEO talent versus managerial power over complacent boards, highlighting the importance of understanding contract complexity and heterogeneity in designing efficient contracts to enhance shareholder value and achieve strategic corporate goals.
Diagnóstico del Gallinazo (Coragyps atratus) como Bioindicador en el Suroccidente de Bogotá–Colombia, Implicaciones Ambientales
Authors: Moreno-Cabal Ana María , Vanegas-Bautista Deisy Nataly , Angulo-De Castro Ivonne , Gaona Luis A.
Published: February 2023

Introducción: Las condiciones de manejo de residuos por parte de algunas industrias de Bogotá y el arrojo de residuos por la población adyacente a estos, es un problema que impacta directamente las condiciones ambientales y de salud pública, en donde la avifauna es atraída por la producción de olores inofensivos y desechos generados por industrias como los frigoríficos, generando problemas de saneamiento. Objetivo: Se realizó un diagnóstico del estado del gallinazo en el área suroccidente de Bogotá y se establecieron medidas de prevención y control de los posibles impactos que atraen a los individuos de la especie. Metodología: El muestreo se realizó mediante la caracterización de aves por observación directa y se realizó la identificación de impactos. Resultados: La abundancia promedio fue de 41,5 individuos para el área total del muestreo, con una densidad poblacional de 117 ind. /km2 para el frigorífico No.1 y 42,8 ind./km2 para el frigorífico No.2. Se identificaron nueve impactos ambientales, uno de importancia ambiental positiva irrelevante, el cual fue el incremento de la población de especies de fauna (en este caso Coragyps atratus) y otro de importancia ambiental negativa moderada que fue la modificación en la calidad del agua, y los impactos restantes negativo irrelevantes. Conclusiones: C. atratus, es atraída por los desechos producidos por las actividades humanas y las industrias. Así mismo, aunque las industrias involucradas en el estudio cuentan con programas de manejo ambiental, aún se observa la presencia de C. atratus, un análisis de mayor profundidad de la situación podría permitir identificar la razón de este hecho.
The Effects of Anti-Retroviral Therapy on Some Renal Parameters of Hiv Sero-Positive Individuals in Rivers State, Nigeria
Authors: Ajuru Gospel , Ifenkwe John , Akujuru Eugene
Published: February 2023

This study investigated the effect of antiretroviral therapy on some
renal parameters of HIV seropositive individuals in Rivers State,
Nigeria. A total of 300 HIV patients, who are undergoing treatment were
recruited in this study, aged 20-70 years. They were classified into
three groups; Group 1, made up of HIV sero-Positive infected individuals
on highly antiretroviral therapy as the test subjects. Group 2 was HIV
sero-Positive infected individual but not on highly active
antiretroviral therapy as control 1. Group 3 was HIV sero-negative
individual as control 2. Ethical approval for the study and informed
consent from the participants was obtained. Renal parameters evaluated
were Urea, Creatinine, Na, K, Ca, HCO3 and uric acid. The results were
statistically significantly higher (P<0.05) in Na, K, HC03,
Urea, creatinine and Ca of test subject and control I. compared to
control II. Also, statistically significant increase (P<0.05)
in Na, K, HC03, urea, Creatinine and Ca, of the test subject and control
1 compared to control II. In relation to sex there was also
statistically significant increase (P<0.05) in Na, K, HCo3,
urea, creatinine, Ca of test subject and control I compared to counted
II in relation to Age group groups. Based on duration of therapy, for
HIV positive patients who have been on Highly Active Antiretroviral
Therapy (HAART) for 0-2years, there were no significant increase
(P<0.005) in Na and calcium level, however there was
statistically significant increase (P<0.05) in K, HC03, urea,
creatinine, Ca. For 10 years and above, there was statistically
significant increase (p<+0.05) in Na, K, HC03, urea,
creatinine, Ca, compared to their respective control I and control II.
This study demonstrated that long term administration of HAART to HIV
infected positive subjects could lead to metabolic disorder which could
predispose the patient to high risk of coronary heart disease.
An intentional random mathematical model of immigration: The case of Spain
Authors: Company R. , Jódar Lucas , Torres Sheila
Published: February 2023

In this paper a random discrete mathematical population model of
immigration is constructed using not only rational factors as the
gradient of economy level among the host and issuing countries, the
geography, or the regulation laws, but also hidden intentional factors
such as political interests of governments, or the business of smuggling
of migrants by mafias, which use the immigration practically as a
weapon. These non-rational factors are modeled as sudden random arrival
flow waves represented by a Poisson distribution. The period of study is
short in order to make reliable the economic forecast of the next years.
Although the study is focused in Spain, the approach is exportable to
other geographic areas by adapting the data. Results are applied to
predict the necessary national budget of the host country to afford this
social phenomenon.
Survey of New Applications of Geometric Algebra
Authors: Hitzer Eckhard , Kamarianakis Manos , Papagiannakis George , Vašík Petr
Published: February 2023

This survey introduces 101 new publications on applications of
Clifford’s geometric algebras (GA) newly published during 2022 (until
mid-January 2023). The selection of papers is based on a comprehensive
search with Dimensions.ai, followed by detailed screening and
clustering. Readers will learn about the use of GA for mathematics,
computation, surface representations, geometry, image- and signal
processing, computing and software, quantum computing, data processing,
neural networks, medical science, physics, electric engineering, control
and robotics.
Treatment with 2-carba cyclic phosphatidic acid (2ccPA) promotes phenotypic switch of M1 microglia to M2 and prevents behavioral abnormalities in a mouse model of neuropsychiatric systemic lupus erythematosus
Authors: Nagata Wataru , Gotoh Mari , Koizumi Akiho , Fukasawa Keiko , Nakagawa Keiichi , Satoh Yasushi , Ishizuka Toshiaki
Published: February 2023

Systemic lupus erythematosus (SLE) is an autoimmune disease associated
with the production of double-stranded DNA (dsDNA) antibodies and other
antibodies, that predominantly affects women, with a wide range of
lesions. Although neuropsychiatric lupus erythematosus (NPSLE),
characterized by neuropsychiatric symptoms related to cerebrovascular
diseases or depression, ranks high in severity, and no specific
treatments have yet been defined. 2-carba cyclic phosphatidic acid
(2ccPA) is a derivative of cyclic phosphatidic acid isolated from a true
slime mold Physarum polycephalum in 1992. Treatment with 2ccPA
reportedly suppresses neuroinflammation and promotes tissue repair in
mouse models of multiple sclerosis and traumatic brain injury. We
performed behavioral tests in MRL/lpr mice as a model of NPSLE. The mice
showed increased depression-like behaviors and decreased emotional
responses to a new environment compared to the control mice. Treatment
with 2ccPA significantly suppressed the behavioral abnormalities in
MRL/lpr mice. In the prefrontal cortex and hippocampus, MRL/lpr mice
showed a significantly elevated expression of CD68, a M1 phenotypic
marker of microglia, which was significantly suppressed by 2ccPA
treatment. In contrast, the expression of Arginase-1, a M2 phenotypic
marker of microglia, was significantly increased by 2ccPA treatment.
MRL/lpr mice showed higher plasma levels of anti-dsDNA antibody, which
is mainly involved in the pathogenesis of SLE, compared to control mice.
Treatment with 2ccPA decreased these levels in the MRL/lpr mice. These
results suggest that 2ccPA treatment promotes phenotypic switch of M1
microglia to M2 and suppresses behavioral abnormalities in MRL/lpr mice.
A rare Case of Pulmonary Embolism in a Mt. Kilimanjaro Recreational Hiker: A Case Report with Review of Literature.
Authors: Eliah Doreen , Nyakunga Gissela , Sadiq Adinan , Dekker Marieke , Mashauri Harold , Sakita Francis
Published: February 2023

Pulmonary embolism (PE) is one of the rarest complications of high
altitude sickness. Case reports are increasingly rising with the
difficult to notice among HAPE patients given their presentation
similarities. A high index of suspicion based on clinical examination
and investigations should prompt a clinician to include or exclude it.
Invasive fungal infections in children with leukaemia in a tertiary hospital in Oman, 8-year review.
Authors: Al-Hatmi Abdullah M.S. , Hajri Hind Al , Al-Salmi Widad , Hinai Karima Al , Al-Housni Saif , Al-Harrasi Ahmed , Hashami Hilal Al
Published: February 2023

Background: Invasive fungal disease (IFD) is a common and
serious consequence of leukaemia in children and the incidence of these
infections increased due to chemotherapy. We present the epidemiology of
IFD in a cohort of children with leukaemia from a tertiary reference
institution in Oman. Methods: A retrospective study of IFDs in
pediatric patients with newly diagnosed or relapsed leukemia was
conducted at the Royal Hospital in Muscat, Oman. From 2010 to 2017, IFD
episodes in children with leukemia were evaluated retrospectively,
taking into account age, gender, type of leukaemia, chemotherapy
regimen, IFD detection phase, neutropenia, prophylaxis, diagnostic
method, and treatment. Results: Between 2010 and 2017, 198
children with leukemia were admitted and treated at Royal Hospital. In
retrospect, the IFI were defined as probable and proven in 53 % (17
patients) and 47% (15 patients) of the attacks. At 1.1:1, the
male-to-female ratio was roughly equal. According to chest computed
tomography (CT) scans, 65.6% of patients had radiological features of
fungal infections. Positive fungal cultures were found in three
patients’ bronchoalveolar lavage (BAL), 37.5% of whom had positive
blood cultures, and 3% of whom had positive urine cultures. In 3
patients, invasive aspergillosis caused pulmonary IFD, accounting for
9.3% of all infection sites. Candidaemia was found in 28% of IFD
patients. The most common organism was Candida tropicalis
(15.6%), followed by Candida prapsilosis (6.25%).
Conclusion: In children with leukemia, invasive fungal
infection is common and serious. Despite aggressive treatment, mortality
among these high-risk patients remains high.
Maternal SMC2 Is Essential for Embryonic Development via Participating in Chromosome Condensation in Mice
Authors: Xu Ke , Qiao Jing-Yi , Wang Zhao-Bing , Dong Ming-Zhe , Lei Wenlong , Li Yuan-Yuan , Schatten Heide , Wang ZB , Liu Kui , Sun Qing-Yuan
Published: February 2023

During oocyte growth, maturation and zygote development, chromatin
structure undergoes continuous changes to regulate different nuclear
activities. Condensin plays an essential role in chromatin
configuration. Here, through oocyte-specific conditional knockout of
SMC2, a core component of the condensin complex, we showed that SMC2 is
essential for the production of healthy eggs and early embryo
development. Maternal SMC2 knockout caused chromosome condensation
defects in oocytes, and subsequently inhibited proper pronuclear
organization in zygotes. As a result, pronuclear function was impaired
and DNA damage was accumulated, which prevented the development of
embryos beyond the zygote stage.
A CASE OF VAGAL CEPHALGIA AS A MANIFESTATION OF A LUNG NEOPLASM -- A CASE REPORT AND REVIEW OF LITERATURE
Authors: Sanker Vivek , Devaragudi Sanjana , Shariff Sanobar , Deva Sheryl , Mathew Robert , Gupta Umang
Published: February 2023

Lung cancer can present with unilateral atypical facial pain, a rare
symptom due to vagus nerve involvement or paraneoplastic syndrome. This
manifestation is usually missed, delaying the diagnosis and prognosis.
We discuss a case of a 45-year-old male who presented with right-sided
hemifacial pain and with normal neurological investigations.
BRCA2 reversion mutation confers resistance to olaparib in breast cancer
Authors: Yamamoto Shinya , Kawashima Kei , Fujiwara Yoshie , Adachi Shoko , Narui Kazutaka , Hosaka Chiaki , Takahashi Rina , Tsuyuki Sho , Sugimori Makoto , Tanoshima Miki , Sasamoto Mahato , Oshi Masanori , Yamada Akimitsu , Kunisaki Chikara , Endo Itaru
Published: February 2023

A 34-year-old woman with breast cancer and the BRCA2: p.Gln3047Ter was
treated with olaparib. After tumor progression, cancer genomic profiling
testing revealed the BRCA2 p.Gln3047Ter and p.Gln3047Tyr, with 48.9%
and 0.37% allele frequency, respectively. These findings shed light on
reversion mutation as a resistance mechanism to olaparib in breast
cancer.
COMPARISON OF EFFICACY OF DIFFERENT DRUG COMBINATIONS IN ACUTE SCIATICA
Authors: Mirza Mehreen , Naeem Uzma , Amjad Madeha , Waheed Akbar , Irshad Mushayada , Mumal Sidra
Published: February 2023

Sciatica, a musculoskeletal condition is a common cause of disability
and early deaths, affecting millions of people globally. The aim of the
study was to evaluate efficacy of different drug combinations for
treatment of acute sciatica. It is a single-center, clinical trial with
three arms, registered at Clinicaltrials.gov; (NCT05626140). Adults from
18-70 years of age were enrolled (n=130). Patients were placed in three
groups each i.e. 40 in diclofenac plus placebo group, 40 in codeine plus
diclofenac group and 40 in lacosamide plus diclofenac group and followed
up for 15 days for change in mean pain scores using Visual Analog Scale
(VAS). Pairwise comparison assessed change from baseline in mean pain
scores. The VAS mean pain scores with combination of lacosamide and
diclofenac showed significant decrease from 7.785cm to 1.115cm. Codeine
with diclofenac displayed a lesser decline of 7.43cm to 2.71cm while
diclofenac monotherapy exhibited the least change from 7.50cm to 3.45cm.
P value was significant (p < 0.001) for 10th and 15th day of
follow up. Adequate analgesia was attained in all the three arms. In
conclusion, combination of lacosamide with diclofenac showed clinical
superiority in relieving symptoms of acute sciatica compared with
diclofenac plus codeine or diclofenac monotherapy.
An Analytical Model for Calculating Particle Impact Rate in Granular Flow
Authors: Chen Zheng , Wang Jian , He Siming , Wang Dongpo
Published: February 2023

High-frequency seismic waves are generated by inter-particle collisions
during granular flows travel downslope. However, the accurate estimation
of particle impact rates over granular layers remains a challenging
issue. Here, controlled laboratory experiments were performed to
investigate basal dynamic pressures triggered by the impact of particles
on an instrumented plate mounted on an inclined chute bed. For a similar
set-up, the discrete element method was utilized to determine
granular-flow characteristics and the rate of inter-particle collisions.
From a thermodynamic perspective, we present a novel model for
calculating the impact rate over the granular-flow depth. Our estimates
agree with the simulated results and previous laboratory measurements of
acoustic power, suggesting that the impact rate follows a Gaussian
distribution across the flow depth and the exponential attenuation
factor of radiated acoustic power may correlate with thermodynamic
parameters of granular material. These findings may help better
understand the source of the high-frequency granular-flow signals.
High-Accuracy Classification of Radiation Waveforms of Lightning Return Strokes
Authors: Wu Ting , Wang Daohong , Takagi Nobuyuki
Published: February 2023

A machine-learning classifier for radiation waveforms of negative return
strokes (RSs) is built and tested based on the Random Forest classifier
using a large dataset consisting of 14,898 negative RSs and 159,277
intracloud (IC) pulses with 3-D location information. Eleven simple
parameters including three parameters related with pulse characteristics
and eight parameters related with the relative strength of pulses are
defined to build the classifier. Two parameters for the evaluation of
the classifier performance are also defined, including the
classification accuracy, which is the percentage of true RSs in all
classified RSs, and the identification efficiency, which is the
percentage of correctly classified RSs in all true RSs. The tradeoff
between the accuracy and the efficiency is examined and simple methods
to tune the tradeoff are developed. The classifier achieved the best
overall performance with an accuracy of 98.84% and an efficiency of
98.81%. With the same technique, the classifier for positive RSs is
also built and tested using a dataset consisting of 8,700 positive RSs.
The classifier has an accuracy of 99.04% and an efficiency of 98.37%.
We also demonstrate that our classifiers can be readily used in various
lightning location systems. By examining misclassified waveforms, we
show evidence that some RSs and IC discharges produce special radiation
waveforms that are almost impossible to correctly classify without 3-D
location information, resulting in a fundamental difficulty to achieve
very high accuracy and efficiency in the classification of lightning
radiation waveforms.
Complete overview of reservoir characterisation in sedimentary basins
Authors: Ibekwe Kelechi N , Oguadinma Vivian O , Okoro Victory K , Aniwetalu Emmanuel , Lanisa Ademola , Ahaneku Chibuzor V
Published: February 2023

Evaluating the subsurface characteristics of reservoirs is an important part of hydrocarbon exploration and production in sedimentary basins. This process combines geological, geophysical, and engineering data to comprehend the subsurface geology and fluid distribution, determine reserves, and predict the fluid movement in the reservoir. The primary goal of reservoir characterization is to create a precise and dependable model of the reservoir to maximize the production procedure and reduce the associated risks of hydrocarbon exploration and production. This review examines different approach utilized for reservoir characterization in sedimentary basins, including geological, geophysical, and engineering methods. Each method’s advantages and disadvantages are discussed, alongside their uses in different reservoir contexts. The importance of combining multiple lines of evidence to enhance the accuracy of the reservoir models is also examined.
Sentinel-1 snow depth assimilation to improve river discharge estimates in the western European Alps
Authors: Brangers Isis , Lievens Hans , Getirana Augusto , Lannoy Gabrielle J.M. De
Published: February 2023

Seasonal snow is an important water source and contributor to river
discharge in mountainous regions. Therefore the amount of snow and its
distribution are necessary inputs for hydrological modeling. However,
the distribution of seasonal snow in mountains has long been uncertain,
for lack of consistent, high resolution satellite retrievals over
mountains. Recent research has shown the potential of the Sentinel-1
radar satellite to map snow depth at sub-kilometer resolution in
mountainous regions. In this study we assimilate these new snow depth
retrievals into the Noah-Multiparameterization land surface model using
an ensemble Kalman filter for the western European Alps. The land
surface model was coupled to the Hydrological Modeling and Analysis
Platform to provide simulations of routed river discharge. The results
show a reduction in the systematic underestimation of snow depth, going
from 38 cm for the open loop (OL) to 11 cm for the data assimilation
(DA) experiment. The mean absolute error similarly improves from 44 cm
to 37 cm with DA, with an improvement at 59% of the in situ sites. The
DA updates in snow depth results in enhanced snow water equivalent and
discharge simulations. The systematic negative bias in the OL is mostly
resolved, and the median temporal correlation between discharge
simulations and measurements increases from 0.61 to 0.73 for the DA.
Therefore, our study demonstrates the utility of the S1 snow depth
retrievals to improve not only snow depth amounts, but also the snow
melt contribution to river discharge, and hydrological modeling in
general.
Multiple Equidistant Belt Technique for Width Function Estimation through A Two-Segmented-Distance Strategy
Authors: Wu Pengfei , Liu Jintao , Feng Meiyan , Liu Hu
Published: February 2023

The arbitrary adoption of cell center to represent the whole cell is a
compromise to the grid structure of the digital elevation models (DEMs),
which greatly limits the accuracy of estimating flow distance and width
functions. This study uses the triangulation with linear interpolation
(TLI) method to approximate the missing flow distance values within a
cell except for the cell center. A new flow distance algorithm (D∞-TLI)
is proposed to improve the flow distance estimation by using a
two-segment-distance strategy. The first segment distance from a cell
center to a crossing point at the local 3 × 3 window boundary is modeled
by the D∞ method. The second segment distance souring from the crossing
point is estimated by the TLI using the flow distance values assigned
for the two closest downstream cell centers, while these values have
been assigned by iterating from lowest to highest cells. Then, using the
continuous flow distance field approximated over a cell region, this
cell can be divided into multiple equidistant belts (MEB) to estimate
the width function. Four numerical terrains and two real-world terrains
are used for assessments. The results demonstrate that D∞-TLI
outperforms nine existing flow distance algorithms over any numerical
terrains, and it is overall optimal for real-world terrains. Meanwhile,
MEB extracts the width function which is less affected by unreasonable
artificial fluctuation than the previous method. Hence, MEB combined
with D∞-TLI can obtain a high-accuracy estimation of
hydro-geomorphological attributes that may be conducive to the
application of hydrologic modeling.
Natural and human-made nesting habitat use by Bank Swallow (Riparia riparia) in Canada
Authors: Pelletier Noémie , Arndt Janice , Darvill Rachel , Cyr Marc-André
Published: February 2023

Bank Swallow (Riparia riparia) is a Threatened migratory bird in Canada that nests colonially in burrows excavated in both human-made and natural banks. Until the mid-20th century, nest record cards reported 60% of Bank Swallows in Canada nested in human-made habitats. Here we provide an update on the proportion of Bank Swallow nesting colonies in natural and human-made habitats in Canada’s provinces and territories based on data from a variety of sources including breeding bird atlases and eBird. Bank Swallow nesting colonies reported from 2001 to 2017 throughout Canada indicate a reversal in the dominant type of habitat used for nesting, with a 56% probability that nesting occurrences are now found in natural habitats. We discuss possible mechanisms responsible for the apparent reversal and recommend that natural nesting habitat be formally protected and restored where it has been altered, especially where co-benefits include climate change resiliency. With the support of landowners and industry, active colonies in human-made habitats will likely make an important contribution to a resilient Bank Swallow population, the majority of which presently appears to nest in natural habitats across the country.
Design of a four stages VCO using a novel delay circuit for operation in distributed band frequencies
Authors: Gogoi Mriganka , Dutta Pranab
Published: February 2023

The manuscript proposes a novel architecture of a delay cell that is implemented in 4-stage VCO which has the ability to operate in two distributed frequency bands. The operating frequency is chosen based on the principle of carrier mobility and the transistor resistance. The VCO uses dual delay input techniques to improve the frequency of operation. The design is implemented in Cadence 90nm GPDK CMOS technology and simulated results show that it is capable of operating in dual frequency bands of 55 MHz to 606 MHz and 857 MHz to 1049 MHz. At normal temperature (270) power consumption of the circuit is found to be 151?W at 606 MHz and 157?W at 1049 MHz respectively and consumes an area of 171.42?m2. The design shows good tradeoff between the parameters-operating frequency, phase noise and power consumption.
New approach to a DS-CDMA-UWB system using a pseudo orthogonal code (POC)
Authors: Biteur Kada , Benadda Belkacem , Ayad Ahmed
Published: February 2023

Ultra-Wideband Direct Sequences Code Division Multiple Access (DS-DMA) plays an important role in the case of multi-terminal multi-application communications of UWB devices. In the case of UWB systems that exploit the injection of the pulse itself directly to the antenna hence the very wide bandwidth, generation of suitable DS-CDMA codes poses a real challenge. In this paper we will describe our novel UWB transmission which uses pseudo-orthogonal time code (POC) as DS-CDMA sequences. The suggested codes are unipolar sequences with chips that may be dynamically modified to target a certain number of users or applications. Our approach bypasses the modulations schemes commonly used on UWB systems. Moreover, as perspectives to our work, it would be very interesting to realize our new approach based on an FPGA circuit.
Performance analysis and optimization of 10 nm TG N- and P-channel SOI FinFETs for circuit applications
Authors: Lazzaz Abdelaziz , Bousbahi Khaled , Ghamnia Mustapha
Published: February 2023

This paper analyses the electrical characteristics of 10 nm tri-gate (TG) N-
and P-channel silicon-on-insulator (SOI) FinFETs with hafnium oxide gate
dielectric. The analysis has been performed through simulations by using
Silvaco ATLAS TCAD with the Bohm quantum potential (BQP) algorithm. The
influence of the geometrical parameters on the threshold voltage VTH, the
subthreshold swing (SS), the transconductance and the on/off current ratio,
ION/IOFF, is investigated. The two structures have been optimized for CMOS
inverter implementation. The simulation results show that the N-FinFET and
the P-FinFET can reach a minimum SS value with Fin heights of 15 nm and 9
nm, respectively. In addition, low threshold voltages of 0.61 V and 0.27 V
for N- and P-channel SOI FinFETs, respectively, are obtained at a Fin width
of 7 nm.
Conceptualization of client ‘needs’ in architectural theory and practice
Authors: Kiyanenko Konstantin
Published: February 2023

The article aims to discuss the ambiguity of the need concept in
architecture, and reasons for the existence of several strategies for
dealing with need as an ontological and epistemological basis for
architectural design. The paper systematizes the conceptualizations of need
in architecture, provides a comparative analysis of its various
interpretations and explains the differences between ideological,
philosophical and theoretical viewpoints. A variety of meanings are analyzed
using the author?s concept of ?paradigms of socio-architectural knowledge?.
Five platforms of social knowledge can be distinguished in architectural
theory, each of which relies on its own understanding of human beings and
sees the content of human existence in its own way. Considered through the
prism of the paradigms, different visions of the concept of need find their
logical and methodological explanation. Each paradigm gives its own answer
to who or what is the bearer and exponent of the need, and procedures for
identifying needs in design. The paper presents ?stairs of needs? as a
metaphor, ordering the range of possible actions of the architect in
relation to the needs of the client - from obstruction and conscious
deformation to satisfaction and phenomenological embodiment.
Role of six cytokines and bone metabolism biomarkers in gingival crevicular fluid in patients undergoing fixed orthodontic appliance treatment in comparison with aligners: a clinical study
Authors: Kamran Muhammad Abdullah , Alnazeh Abdullah A. , Almagbol Mohammad , Almoammar Salem , Alhaizaey Ali Hasan A. , Alshahrani Ibrahim
Published: February 2023

Objectives

The objective of this study was to assess bone biomarkers and cytokines in patients with conventional labial appliances (CLAs) and aligners.

Materials and Methods

Participants were recruited to undergo orthodontic treatment with CLAs and aligners according to predefined inclusion and exclusion criteria. Periodontal examination was accomplished at baseline and 4 weeks using the plaque index (PI), gingival index (GI), and bleeding on probing (BoP). Samples of gingival crevicular fluid (GCF) were collected at baseline (T0) before the start of treatment and at the 1-month follow-up (T1) to assess bone metabolic and inflammatory biomarkers. GCF from participants with CLAs and aligners was evaluated with enzyme-linked immunosorbent assay. Comparison between labial conventional orthodontic treatment and aligners were assessed using an unpaired t-test. The difference between T0 and T1 was measured using a paired t-test.

Results

BoP, PI, and GI demonstrated no significant difference between participants treated with aligners and subjects with CLAs at baseline and at 4 weeks (P > .05). Bone markers and other biomarkers (tumor necrosis factor α, interleukin [IL]-α, IL-2, IL-6, and IL-8) showed significant differences (P < .05). Also, a significant difference between CLAs and aligners was noted among all biomarkers (P < .05) except IL-β.

Conclusions

Aligners and CLAs increase the level of inflammatory and bone metabolic biomarkers after 1 month.
Direct immunofluorescent findings in scleroderma syndromes
Authors: Connolly SM , Winkelmann RK
Published: February 2023

Cutaneous direct immunofluorescent findings were examined in 78 patients who had either vascular scleroderma (group 1, 52 patients) or scleroderma with features of myositis or lupus erythematosus (group 2, 26 patients). Group 2 had higher antinuclear antibody levels, erythrocyte sedimentation rates, serum IgG concentrations, frequency of positive LE clot test, and rheumatoid factor activity. Ninety-two percent of group 1 (48 patients) had negative direct immunofluorescent findings, whereas 77% of group 2 (20 patients) had positive findings at the basement membrane or in the blood vessels (or both). The 6 patients in group 2 who had negative immunofluorescent findings were all on systemic steroid therapy. Of the 17 patients in group 2 who had tests for antibody to extractable nuclear antigen, only 3 had high-titer antibody to ribonucleoprotein--a pattern characteristic of mixed connective tissue disease. Direct cutaneous immunofluorescence is proposed as a means of identifying those patients with scleroderma who may be steroid-responsive.