bluuebunny/crossref_metadata_2025 huggingface dataset:
DAMPAK MEDIA SOSIAL DAN WORD OF MOUTH TERHADAP OVERTOURISM
Authors: Hulu Meitolo , Putri Fenisa , Natasya Stephanie , - Michelle
Published: November 2021

ABSTRAKEra digital telah mengubah gaya hidup masyarakat menjadi pengguna media sosial. Penggunaan media sosial menjadi meningkat dalam menyebarkan berita maupun dalam mencari berita. Informasi pariwisata dan berbagi pengalaman berwisata sering dilakukan oleh wisatawan melalui media sosial yang memicu ketertarikan calon wisatawan untuk berkunjung di suatu destinasi. Penelitian ini menganalisis dampak media sosial dan word of mouth terhadap over-tourism dengan pendekatan kuantitatif menggunakan alat analisis Smart PLS 3. Metode survey digunakan untuk menyebarkan kuesioner kepada 106 mahasiswa yang menggunakan media sosial dalam mencari informasi. Hasil penelitian ini menunjukkan bahwa media sosial dan word of mouth berpengaruh positif dan signifikan terhadap over-tourism. Artinya semakin banyak pengguna media sosial serta pelaku word of mouth memberikan kontribusi terhadap peningkatan jumlah wisatawan yang mengakibatkan terjadinya over-tourism. Pemangku kepentingan pariwisata harus mengelola media sosial dengan baik supaya tidak terjadi kesalah-pahaman baik dari pemberi informasi maupun penerima informasi, karena media sosial merupakan salah satu cara dalam membangun hubungan dengan wisatawan dan calon wisatawan.Kata Kunci: media sosial, word of mouth, over-tourism, pariwisata, wisatawanABSTRACTThe digital era has changed people's lifestyles into social media users. The use of social media is increasing in spreading the news as well as in searching for news. Tourism information and sharing of travel experiences are often done by tourists through social media which triggers the interest of potential tourists to visit a destination. This study analyzes the impact of social media and word of mouth on over-tourism with a quantitative approach using the Smart PLS 3 analysis tool. The survey method was used to distribute questionnaires to 106 students who used social media to find information. The results of this study indicate that social media and word of mouth have a positive and significant effect on over-tourism. This means that more and more social media users and word of mouth actors contribute to the increase in the number of tourists which results in over-tourism. Tourism stakeholders must manage social media well so that there are no misunderstandings from both information givers and recipients of information, because social media is one way to build relationships with tourists and potential tourists.Key words: Social media, word of mouth, over-tourism, tourism, tourists
HUBUNGAN JUMLAH OBJEK WISATA, HOTEL DAN BIRO PERJALANAN DENGAN JUMLAH WISATAWAN KE D.I.Y.
Authors: Yulianto Atun , Mayasari Citra Unik
Published: November 2021

ABSTRAK Banyaknya jumlah kunjungan wisatawan di Daerah Istimewa Yogyakarta menjadi peluang besar bagi pelaku industry pariwisata untuk mengembangkan bisnisnya. Namun demikian dibutuhkan konsistensi dalam pengembangan pengelolaan yang berkesinambungan untuk dapat bertahan dalam persaingan. Hal ini  terkait dengan kreativitas pengelola untuk berinovasi dalam industry wisata agar usaha pariwisatanya diminati masyarakat. Tujuan penelitian ini adalah untuk mengetahui hubungan antara jumlah objek wisata, hotel dan biro perjalanan dengan jumlah kunjungan wisatawan ke tujuan wisata di D.I. Yogyakarta. Metode penelitian yang digunakan dengan pendekatan diskriptif kualitatif yang didukung analisis data kuantitatif. Hasil penelitian menunjukkan adanya hubungan yang signifikan antara jumlah hotel dan biro perjalanan dengan jumlah kunjungan wisatawan. Nilai signifikansi mendekati 0,000 pada tingkat probabilitas 5%. Sementara jumlah objek wisata tidak memiliki hubungan erat dengan jumlah kunjungan, namun jenis objek wisata memiliki potensi hubungan terhadap jumlah kunjungan wisatawan. Kata Kunci: Objek Wisata, Hotel, Biro Perjalanan, Kunjungan Wisatawan ABSTRACT The large number of tourist visits in the Special Region of Yogyakarta is a great opportunity for the tourism industry players to develop their business. However, consistency in the development of sustainable management is needed to survive in the competition. This is related to the creativity of managers to innovate in the tourism industry so that their tourism business is in demand by the community. The purpose of this study was to determine the relationship between the number of tourist objects, hotels and travel agencies with the number of tourist visits to tourist destinations in D.I. Yogyakarta. The research method used is a qualitative descriptive approach supported by quantitative data analysis. The results showed a significant relationship between the number of hotels and travel agencies with the number of tourist visits. The significance value is close to 0.000 at the 5% probability level. While the number of tourist objects does not have a close relationship with the number of visits, the types of attractions have a potential relationship to the number of tourist visits. Keywords: Tourism Object, Hotel, Travel Agency, Tourist Visit
La conceptualización errada del campo eléctrico con cálculo integral en clases virtuales en estudiantes de física aplicada
Authors: Coello Pisco Silvia Magdalena , Flores Herrera Jorge , Hidalgo Crespo José Armando , Gonzalez Cañizalez Y.
Published: November 2021

En este trabajo se replicó un método basado en el teorema de Vergnaud sobre la conceptualización del campo eléctrico con cálculo integral realizado en una universidad privada de la ciudad de Guayaquil. El objetivo  de este estudio es relacionar y conectar la interacción que existe entre el dominio conceptual – epistemológico (Saber comprender) con el hacer del dominio metodológico (Saber hacer) con el propósito de ampliar y profundizar el concepto mediante la experimentación a través de un material instruccional en las clases virtuales (Teoría de Gagné). Nuestro trabajo se fundamenta en la investigación acción con un enfoque explicativo, ya que desde la óptica de la práctica pedagógica pretendemos dar respuesta a los problemas de conceptualización sobre las variables que participan en el campo eléctrico. El diseño del estudio es experimental se trabajó con grupos intactos, uno de control (Gc) y otro experimental (Ge).  Los resultados indican que el grupo experimental desarrolló una mejor conceptualización en los contenidos de campo eléctrico con cálculo integral a diferencia del grupo de control que recibió una instrucción tradicional.
Despite Genetic and Proteomic Arguments, the Three Common Variants of NOD2/ CARD15 Genes: Pemphigus Foliaceus
Authors: An Chaounge
Published: November 2021

Background: Knowledge about the pathogenesis of Pemphigus Foliaceus (PF), an autoimmune disorder of the skin natural barrier, is still modest. Genetic susceptibility factors have been widely studied, while environmental factors remain still ambiguous. NOD2/CARD15 gene encodes an intracytoplasmic receptor involved in recognition of microbial components and NF-κB inflammatory signaling pathway. Three common CD-associated variations (R702W, G908R and 1007fs) cause a "loss of function" of the molecule and lead to a chronic inflammation in the intestinal epithelial barrier. The aim of this study is to analyze NOD2/CARD15 gene polymorphisms in Tunisian endemic PF. Methods and Results:A case-control study including 79 PF patients and 160 controls was conducted using PCR-RFLP and direct sequencing. Our results showed that the three SNPs are not polymorphic in both patients and controls (allelic frequencies were 0.63% vs 1.25%, 0.63% vs 1.87% and 0% vs 0.62%, respectively). There was no association of mutant alleles with the disease. Conclusions: Our results suggest that the three common variants of NOD2/CARD15 gene are not involved in susceptibility to Tunisian PF. The alteration of the molecule's functionality caused by these mutations seems to not interfere with the development of the disease.
The Dynamic Microanatomy of skin and fascia. From the deep fascia to the skin surface.
Authors: Morales-Avalos Rodolfo , Requena-Araujo Priscila Madelein
Published: November 2021

The study of the structure of the skin and fascia in recent years has made important advances with respect to the "dynamic anatomy" that they present, that is, the anatomical relationships and tissue interconnections that you share through different tissues. In the same way fascias have been recognized as important sources of origin of different pathologies in the last years, so the greater knowledge of their function and structure is indispensable. The aim of this article is to review the last advances in the anatomic terminology of the soft superficial tissues as advances and recent anatomical discoveries.
Onychomycosis with Photodynamic Therapy of Fingernails
Authors: Rafel Abdur , Sodi Ibrahim , Said Sattar , Hussain Nadima
Published: November 2021

The advances in laser technology have led to many new devices and uses. Lasers have been used to treat onychomycosis, but this technology is in its infancy. Laser therapy for the temporary cosmetic improvement of onychomycosis of toenails received FDA approval in 2010. We report a patient treating onychomycosis of the fingernails using the Genesis Plus laser. The advantages are the simplicity of the procedure, no concern for systemic (drug) reactions or contraindications, and the efficacy of the procedure. The disadvantages include cost, the necessity for individualization of settings with clinical analysis of nail involvement and thickness, and slight warmth or heat during the procedure. We feel this modality provides a great service to dermatologic patients, especially those with co-morbidities, and dermatologists should be aware of this use.
A case report of Acne Vulgaris: Treated by combination of Acupuncture
Authors: Hoque Tania
Published: November 2021

A 23years of female patient came at Gonosashthaya Somaj vittik Medical college, Savar 1yr back with the complains of – Multiple papulo-pustular scattered lesions over face, neck and back for 5-6yrs She was diagnosed as a known case of Acne Vulgaris 2yrs back And treated here with anti-acne medicine for 1yr. Past history - She got no history of allergy, asthma Personal history – She took lots of cosmetics and herbal products for her fairness. She is married for 5yrs and have one female healthy child of 3yrs; she never took any contraceptive method.
Multiple Nail Candidosis in a Child with APECED Syndrome
Authors: M Chaouche , A Dah Cherif , Y Barbach , S Gallouj , FZ Mernissi
Published: November 2021

The APECED syndrome (autoimmune polyendocrinopathy, candidosis, ectodermal dystrophy) is a rare autosomal recessive disorder that develops in early childhood and results in tissue-specific multiorgan autoimmunity, leading to the hypofunction of multiple glands. Is clinically defined as the presence of at least two components of the classic triad of hypoparathyroidism, adrenal insufficiency, and mucocutaneous candidiasis. We report a case in a child, illustrating the importance of dermatological disorders.
Periodontal Muscle Training Can Strength the Periodontal Support, Fit Your Teeth
Authors: Sabzchamanara Nima
Published: November 2021

Statiatical analysis, A total of 505 patients in general practice were asked to respond to a list of 25 obligatory nourishment for a child while going to have the first teeth, for its effectiveness in dealing with patient's periodontal health especially include chewing hard food. They were also asked to select the three effective nutrition for periodontal tissue. The indicts of patient perceived importance of the periodontal health were derived and each compared with actual effectiveness as determined from a sample of 250 patients opinion. Although the majority of patient's 18 of 25 nutrition as being very effective, there was no significant association with patient perceived nourishment effectiveness and actual effectiveness. The implications for patient training are discussed.
Evaluation and correlation of depth cure and degree of conversion of bulk-fill posterior restorative composite resins
Authors: M. Hamouda Ibrahim , A. Almalki Majed
Published: November 2021

Background: The problem of composite resin filling is the longer time consumed for incremental application. Bulk-fill composite resins were introduced to the market as substitutes for dental amalgam for restoration of posterior teeth. Objectives: The aim of this study was to evaluate the curing depth and degree of conversion of two bulk-fill composite resins. Materials and methods: . Specimens of specific dimensions were prepared from Glacier and SureFil (universal shade, A2), they classified as bulk-fill composite resins. Depth of cure, degree of conversion at different thicknesses for each material (2,3,4,5 and 6 mm) for each thickness separately. The curing depth was determined by the scrapping method (ISO 4049, 2000). The degree of conversion was measured by the Buker FTIR Spectroscopy. Results: The results indicated that, Glacier composite resin has greater curing depth than that of SureFil composite resin. Glacier composite resin was cured above 6 mm thickness, while SureFil composite resin was cured above 5 mm. In general, the degree of conversion was different at the different thicknesses of the materials. SureFil composite resin showed highest degree of conversion at 3 mm followed by 2 mm thickness, while the lowest degree of conversion was noted at 6 mm thickness. Glacier composite resin has the highest degree of conversion at 3 mm followed by 2 mm thickness, while the lowest degree of conversion was noted at 6 mm thickness. SureFil showed positive correlation between the depth of cure and the degree of conversion. Glacier composite resin showed no significant correlation between the depth of cure and degree of conversion. Conclusions: The studied bulk-fill composite resins, cured up to 5mm to 6mm thicknesses. 2 and 3mm thicknesses adequately polymerized than 4 mm, 5 mm and 6 mm thicknesses. The degree of conversion of 2 mm and 3 mm thicknesses was greater than that of the other thicknesses. There was positive correlation between the degree of conversion and curing depth of SureFil composite resin. On the other hand, Glacier composite resin showed no significant correlation between the depth of cure and degree of conversion.
Accelerated Orthodontics: A Review
Authors: Kulshrestha Rohit , Vibhute Pavankumar , Patil Chetan , Umale Vinay , Balagangadhar Balagangadhar
Published: November 2021

Nowadays, there is an increased tendency for researches to focus on accelerating methods for tooth movement due to the greater demand for adults for a shorter orthodontic treatment duration. Unfortunately, long orthodontic treatment time has many disadvantages like higher predisposition to caries, gingival recession, and root resorption. This increases the demand to increase tooth movement with the least possible disadvantages. Several modalities have been reported for accelerating the tooth movement. Thus, accelerating orthodontic tooth movement and the resulting shortening of the treatment time would be quite beneficial.
A review of biomechanical studies for mandibular angle fracture internal fixation
Authors: P.S. Guastaldi Fernando
Published: November 2021

Mandible fractures correspond to 19-40% of all facial fractures. Among all mandible fractures, 12-30% are fractures of the mandibular angle. These fractures are mainly caused by sports activities, interpersonal violence and car accidents. The presence of the third molar and the thin transverse bone area seem to be responsible for the frequent involvement of the mandibular angle in facial fractures. Before the advent of antibiotics, a high frequency of infection was always associated after an open reduction in mandibular angle fractures. Wired osteosynthesis and maxillomandibular fixation (MMF) were traditional methods for fixing mandibular angle fractures. The limitation of both methods has influenced the development of new approaches for the treatment of mandibular angle fractures. Currently, osteosynthesis of mandibular angle fractures with plates and screws has become an effective treatment option. Several forms are described in the literature as: fixation of bone segments with a miniplate on the upper edge of the mandible, fixation with two miniplates, lag screw or by a single rigid plate on the lower edge of the mandible. The purpose of this study was to summarize the main characteristics of biomechanical studies such as the type of mandible source used, the plating techniques employed, the plate material, and the loading protocols used to evaluate the stability of the fixation methods. The Medline (PubMed) database was searched combining relevant terms and pertinent articles in English were included. Articles had to meet the following inclusion criteria: be in vitro biomechanical studies evaluating fixation methods for mandibular angle fractures. A total of 27 articles fulfilled the inclusion criteria. Synthetic mandibles (n=12), animal mandibles (n=9), and human cadaveric mandibles (n=5) were used as the sample source to perform the biomechanical analysis. One article used both synthetic and human cadaveric mandibles. Also, a variety of fixation techniques was described such as mini-plates, lag-screws, reconstruction plates, and three-dimensional plates. The materials of the bone plates used were: stainless steel, commercially pure titanium, titanium alloy or bioresorbable. However, there was inconsistency in reporting the materials and not all studies clearly stated the material of the bone plates. For the biomechanical analysis, there was a high variation among all studies regarding the loading protocols used. The same side of fixation, the anterior part of the mandible (central incisors) or the contralateral side were reported as the dentate regions in which the force was applied. For more than 2 decades, in vitro biomechanical studies have been used to help researchers and clinicians in the field of Oral and Maxillofacial Surgery to properly evaluate and compare the different devices and techniques available for the treatment of mandibular angle fractures. Also, biomechanical studies are important to answer questions on fatigue performance and fracture strength on the gross level.
Accuracy of Alvarado Scoring System and Selective Computed Tomography in Diagnosis of Suspected Cases of Acute Appendicitis
Authors: AR Mohamed Abbas , A Mobarki Safaa , Al Qabasani Ashwag H , Al Shingiti Nusiba A , El Sayed Alaa A
Published: November 2021

Objective: To evaluate the diagnostic accuracy of combined Alvarado scoring system and selective computed tomography (CT) in the diagnosis of suspected cases of acute appendicitis. Material and methods: This study was conducted during the period March 2018 to January 2020 at Prince Mohammed bin Abdul-Aziz hospital (NGHA) in Al Madinah, KSA. It is a prospective study involving 100 consecutive patients attending the emergency department with right iliac fossa pain, excluding children below the age of 14 years and pregnant women. All patients were initially assessed by the Alvarado scoring system, and the result of each patient was recorded in a separate predesigned data sheath. Based on the patient's calculated Alvarado scores, patients were stratified into three groups: Group A (score ≤ 4), Group B (score 5-6), and group C (score ≥ 7). All patients in group A were discharged from the emergency department with instruction to return if their symptoms persist or get worse while all patients in group B had an abdominal multidetector CT scan (MDCT) with IV contrast and no oral contrast to help the diagnosis. Group C patients had surgery without further investigation. Alvarado scores were compared to intraoperative findings and histopathological examination of the removed appendix in those who were operated. The sensitivity, specificity, positive and negative predictive values of the scoring system in each group were calculated with special reference to the role of CT scan in improving the diagnostic accuracy of the scoring system in the middle group (group B). Result: 58 patients were male and 42 were female. Age range between 14 and 43 years with median age 24 years. Out of the 100 patients, 14 (8 males, 6 females) belonged to Group A, 23 (11 males, 12 females) to Group B and 63 (39 males, 24 females) to group C. Two patients from group A (one male and one female) were returned with worsening symptoms and subsequently operated for acute appendicitis. CT scan established the diagnosis of acute appendicitis in 16 out of the patients of group B with subsequent histological confirmation of acute appendicitis in 15 of them. Histopathology confirmed the diagnosis of acute appendicitis in 32 out of 63 patients of group C. Conclusion: Alvarado score has a high accuracy of ruling in and out acute appendicitis at the extremes of the score (≤7 and ≥4), however, the accuracy of the score to confirm or rule out acute appendicitis in the middle group (5 -6) is significantly low. Selective utilization of CT scan in patients in the middle of the score improves the diagnostic accuracy of the score and limits overutilization of CT scan in the other patients at the extremes of the score saving patients unnecessary exposure to radiation and health authorities’ time and cost without increasing the rate of negative appendectomy.
Arteriovenous Malformations of the Uterus: A Case Report and Review and Update of the Literature
Authors: Venyo Anthony Kodzo-Grey , Bakir Emad , M.Khafaji Fatima , Mohamed Rowaa Isam Eldin Seidahmed , Rehman Saad Ur , Darweesh Adham
Published: November 2021

Arteriovenous malformation of the uterus (AVMU) is a terminology that is used for an abnormal and non-functional connections between the uterine arteries and uterine veins. Even though patients who have AVMU typically tend to manifest with vaginal bleeding, some patients tend to experience life-threatening massive bleeding in some circumstances. Cases of AVMU had previously been safely and effectively treated by means of hysterectomy which meant that the patients would no longer have the ability to conceive and have their own babies in the future. Less than 100 cases of AVMU have been reported in the literature. Recently a minimal invasive procedure of Uterine Artery Embolization has been utilized to safely and effectively treat some patients who had AVMU that was associated with severe bleeding that led to cessation of their bleeding and associated symptoms as well as which enabled the patients to maintain their fertility. We report the case of a 27-year-old woman. Gravida 1. Para 0, who was known to have irregular menstrual periods pursuant to her per vaginal passage of conception products. She was diagnosed as having AVMU based upon various radiology imaging options including: ultrasound scan of the pelvis; magnetic resonance imaging of the pelvis, and percutaneous left anterior internal iliac angiography. The AVMU was safely and effectively treated by means of percutaneous interventional radiology embolization of the AVMU and the final angiogram demonstrated satisfactory embolization which led to cessation of her vaginal bleeding and subsequently her retained products of conception were evacuated completely. As a result of the successful embolization of her AVMU, hysterectomy which was the alternative treatment option that was discussed, her uterus has remained intact which has given her the chance to be pregnant again in the future which would enable her have her own child. Considering that less than 100 cases of AVMUs have been reported in the literature, there is the chance that some clinicians may not be familiar with the manifestation, diagnosis, and management of AVMUs, in view of this we have also included miscellaneous narrations and discussions related to some case reports, case series, and studies related to AVMUs. Considering that there are few well-trained interventional radiologists globally as well as few interventional radiology units globally with fewer unts in the developing countries, we would recommend that more interventional radiologists should be trained globally and more interventional radiology units should be established globally especially in the developing countries.
Evaluation of Clinical Presentation and Associated Comorbid Conditions in Patients with Spontaneous Intracerebral Hemorrhage in a Tertiary Care Hospital in Bangladesh
Authors: Ronald Gomes Richmond , Islam Shoriful , Hasan FM Monjur
Published: November 2021

Spontaneous intracerebral hemorrhage (ICH) has remained the least treatable form of stroke despite recent improvements in medical treatment. Treatment usually supportive and medical such as ventilatory support, blood pressure reduction, osmotherapy, fever control, seizure control and nutritional support and treatment of co morbidconditions. This study was carried out to see demographic variability, clinical presentation, causes and outcome of spontaneous intracerebral hemorrhage. Methods and materials: This was a cross sectional observational prospective in study on 50 spontaneous ICH patients admitted in Medicine department of Khulna Medical College Hospital from November 2020 to April, 2021. Result: The study showed that spontaneous ICH was most common in between 41-70 years. Their age frequency were 14 (28%) in 41-50 years, 15 (30%)in 51- 60 years, 12 (24%) in 61-70 years, 5 (10%) in 71- 80 years and 4 (8%) in more than 81 years age group. Among the patients, 64% (32) were male and 36% (18) were female. No of smoker male was 25(50%) and female was 1(2%) and no of nonsmoker male was 7(14%) and female was 17(34%). Headache was present in 56% (28) and absent in 44% (22) of patients. Vomiting was present in 54% (27) and was absent in 46% (23)of patients.Seizure was present in 16% (8) and was absent in 54% (42) of patients. Diabetes mellitus was present in 22% (11) of patients and absent in 78% (39) patients. Range of blood pressure –<140/90 in 24%(12), Systolic BP:140-159/Diastolic BP:90-99 (mm Hg) in 10%(5), Systolic BP:160-179/Diastolic BP:100-109 (mm Hg) in 22%(11),Systolic BP:180 or more/Diastolic BP:110 or more (mm Hg) in 44%(22) patients. Dyslipidemia was present in 30% (15) & absent in 70% (35) patients. Glasgow Coma Scale Score was 8 or less in 42% (21) and 9 or more in 58% (29) patients. Conclusion: Spontaneous ICH is common in Indian subcontinent. As death occur due to ICH itself, associated co morbidities or due to complications, management in stroke care unit, High dependency unit and Intensive care unit is required.
Phytochemical & Pharmacological Studies of Moltkiopsis ciliata
Authors: Kamil Mohammad , M. T. Abdalla F. Ahmad,
Published: November 2021

The stem and branches have silvery white colour with a pink tint. They bear stiff covering trichomes and leaves or leaves remaining are found at their numerous inter nodes. Dark brown scars are left by falling leaves. The branches are brittle and their outer layer separate on breaking. Microscopically، the powder shown many free conical، warty، tapering covering trichomes of various lengths and sizes; the comparatively smaller ones belong to leaves while the significantly large ones are detached from stem and branches. The powder also shows light orange-brown fragments of leaf exhibiting compact endings of palisade cells rounded in outlines; some of these fragments bear many covering trichomes. There are also many grey or grayish-brown fragments of fibro-vascular tissues of branches، some are thick and closely packed، in addition to many fragments of light brown bark cells polygonal or almost square in outlines.
Caudal Regression Syndrome
Authors: Bouchenaki F. , Badache K. , Habchi N. , Benachour M S. , Bakhti S.
Published: November 2021

Caudal Regression Syndrome (CRS) is a rare malformation syndrome associating to varying degrees agenesis of the coccygeal or lumbosacral vertebrae.This vertebral anomaly can therefore be reduced clinically to a simple coccygeal agenesis without any deficit or even lumbosacral agenesis accompanying a clinical picture with sphincter disorders associated or not with transit disorders and various deficits involving the lower limbs.This syndrome is accompanied by other orthopedic malformations such as shortening of the lower limbs, and / or gastrointestinal abnormalities, see also genitourinary as well as cardiovascular.Its incidence is 1 to 5 cases per 100,000 births. Its precise cause has not yet been identified, but its relationship to maternal diabetes is well established. We report in our study 5 patients with CRS from different clinics whose sphincter disorders were found in the foreground in all our patients and whose results vary according to the inaugural clinical picture. MRI made it possible to refine and confirm the diagnosis highlighting the congenital anomaly and the associated lesions.We have obtained 75% good results and 25% clinical stabilization; nor do we deplore any case of aggravation or death. The interest is to suspect the diagnosis of CRS; document it at the start of the prenatal period and determine its severity and associated abnormalities in order to present options for patient management; because once the diagnosis is made, surgical treatment becomes imperative due to the formidable neurological sequelae compromising the functional prognosis.
Low Grade Abdominal Leiomyosarcoma with Liver Metastasis: A Second Cancer Twenty Years after Treatment for Nasopharyngeal Cancer
Authors: Yosra Yahyaoui , Achref Ghorbel , Lamia Charfi , Ahmed Gamoudi , Azza Gabsi , Amel Mezlini
Published: November 2021

Background: leiomyosarcoma is one of the most frequent soft tissues and abdominal-pelvic sarcomas however intra-abdominal leiomyosarcoma with liver metastasis remain a very rare disease. Case presentation: A 61 year-old man presented in February 2019 a recent history of abdominal pain and weight loss. Imagery showed a 5 cm abdominal mass with multiples liver lesions. Biopsy of the liver lesions concluded to a metastases of a low grade leiomyosarcoma. Surgical resection was deemed not possible due to anatomical restrictions and the patient received 6 cycles of systemic mono-chemotherapy with epirubicin. A CT scan performed after the chemotherapy showed a stable disease using RECIST criteria. Conclusions: In case of an unresectable liver metastasis palliative chemotherapy can be offered although it is widely recognized that leiomyosarcoma show moderate sensitivity to chemotherapy.
Candidates for Treatment of Novel Corona virus disease, COVID-19: Current Scenario and Way Forwards
Authors: Bashar Abu
Published: November 2021

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), has spread across the globe resulting in a pandemic affecting 215 countries. At the time of this review, COVID-19 has been diagnosed in more than 15,000,000 patients and associated with over 1,00,000 deaths globally (Canters for Disease Control and Prevention, World Health Organization). In this review, we herein summarize the current evidence as on June 15, 2020 to provide guidance on potential drugs for COVID-19 treatment or prophylaxis, their scientific rationale and their clinical efficacy and safety. New data continue to emerges daily regarding clinical characteristics, treatment options, and outcomes for COVID-19. Optimized supportive care remains the mainstay of therapy, and the clinical efficacy for the potential therapeutic agents is still under investigation.
The Survival Of All Ceramic Crowns With A Zirconia Core (Lava™)
Authors: wei Gang , Dai Jiang , Xiao Ling , Dong Chen , Liu Fei
Published: November 2021

Background: Few studies have assessed the survival of restorations and particularly zirconia based crowns in the restoration of the severely worn dentition. This study aimed to determine survival and factors associated with failure in anterior teeth worn through to dentine restored with Lava™ crowns. Methods: A convenience sample of 30 participants (27 male, 3 female) had 161 Lava™ crowns placed by one specialist clinician in a hospital setting. Follow-up was over a median 72 month period. Results: Of the 161 Lava™ crowns only 25 failed (15.5%) in 15 individuals up to 84 months for the longest case. Major failures were total debond (N=7) or minor delamination chips within the veneer ceramic layer (N=18). The mean time to first failure was 25.23 months. The Kaplan Meier survival plot estimated the Mean Survival Time for the crowns to be 74 months (95%CI 70.4, 77.3). Failures by subject were not associated with an increase in Occlusal Vertical Dimension using a Dahl approach but were associated with an edge-to-edge incisal relation (p<0.05), attrition (p<0.05) and bruxism (p<0.005). Conclusion: The Kaplan Meier survival plot estimated the Mean Survival Time for the crowns to be 74 months. The high loads in bruxism result in increased risk of fracture or debond. Clinical relevance: A protective bi-laminar splint is thus advisable. Nonetheless, application of zirconia based crowns in a difficult clinical situation such as bruxism can be a successful treatment modality.
Clinical and morphological factors associated with two groups of concordant breast cancer immunophenotypes
Authors: Vieira Daniella Serafin Couto , Dufloth Rozany Mucha , Walter Laura Otto , Moraes Ana Carolina Rabello de , Silva Jr João Péricles da , Schmitt Fernando Carlos De Lander , Santos-Silva Maria Cláudia
Published: November 2021

This study aimed to describe the prevalence of invasive breast cancer (IBC) in women assisted in a public hospital in Brazil and to establish a correlation between two models of classification by immunophenotypes, one of them based on the 13th St. Gallen Conference classification and the other on biomarker-defined subtypes based on HER2 and oestrogen receptor status, as described in World Health Organization (WHO). We selected IBC of 1335 cases between 1994 and 2018. Univariate frequencies and associations were estimated using chi-square tests. The concordance between the two immunohistochemical analysis models above mentioned using Cohen's kappa coefficients. The most prevalent subtype was luminal B/HER2, and the frequency of tumours with a worse prognosis was 62.7%. Has been identified an association between histological grade 3 (G3) and the worst prognostic subtypes: non-luminal A, Triple Negative Breast Cancer (TNBC), non-ER+/HER2- and ER-/HER2-. A similar association was found in nuclear G3 tumours. The results showed agreement between 99.48% and 100% when we compared the two immunohistochemical analysis models. Furthermore, there was an absolute agreement between the two models of immunohistochemical analysis. These results can contribute to institutions that do not have a molecular investigation, enabling accessible routine practice tools. Among the most important questions addressed in this work is the association between histological and nuclear G3 with the worst prognostic subtypes. Using the St. Gallen Conference classification and HER2 and ER status based on subtypes verified the feasibility of selecting IBC with different prognoses and correlated them with recognized predictive and prognostic factors.
A Course Redesign Project
Authors: Robertson William H.
Published: November 2021

In the summer of 2019, a cooperative team of Biology faculty and a principal investigator worked to develop a solid set of aligned student learning outcomes across the sections of first semester (BIOL 1305) and second semester (BIOL 1306) of introductory Biology.  Additionally, the group worked on course objectives alignment within the scope and sequence of the courses, as well as aligned syllabi. A full course redesign was initiated over the summer, where the goal was to align student learning outcomes (SLOs), assessments, and develop a shared set of syllabi for six sections across two courses of introductory biology. 

At UTEP, the overall goal was to integrate adaptive courseware technology tools, open education resources (OER) and active learning strategies within a course redesign in our Learning Management System (LMS), Blackboard, for a number of sections in Biology 1305 and Biology 1306 beginning in the spring of 2020. This is challenging, as much of adaptive courseware technology is not as strong in content as the Biology faculty would like for these classes, although it can help to substantially reduce the costs for students.  The information that follows defines the case study for integrating adaptive courseware within the course redesign process for a series of high enrollment introductory Biology courses
Evaluation of the Food Service provided in the 2nd Engineering Group
Authors: Leveau Bruno Martins , Gomes da Silva Jonas
Published: November 2021

The food system of the Brazilian Armed Forces is governed by specific rules and financed by federal collections. In this context, the research proposes a methodology that allows evaluating the average level of satisfaction of users of the foodservice provided in the Procurement of the 2nd Engineering Group, located in the city of Manaus, capital of Amazonas. Therefore, an online questionnaire was developed and applied, adapted from the model proposed by Barros (2013), using four quality dimensions: (i) product quality; (ii) environmental conditions; (iii) facilities; and (iv) employees. The questionnaire has 19 items distributed among the four dimensions, in which the respondent indicated their level of satisfaction using the 10-point Likert scale. The questionnaire was available for ten days and obtained 105 respondents. Data were analyzed using the mean and standard deviation of dimensions and items. It was observed that the “employees” dimension obtained the best evaluation, and the item with the best performance was “employees' hygiene”. On the other hand, the “facilities” dimension had the worst performance, and the main item that needs improvement is “access to people with special needs”. After analyzing the data, the main conclusion of the survey was that the level of customer satisfaction with the aforementioned food service is “GOOD”. In the end, improvement suggestions were made for five items considered to be the most critical. For future studies, it is suggested to evaluate the level of customer satisfaction with that service after applying the improvement actions suggested in this work.
Effective Role of Village Health Volunteers (VHVs) in Response to the COVID-19 Pandemic Emergencies in Thailand
Authors: Tanthanapanyakorn Phannathat , Saykaew Tammasak , Ampant Pravi , Wongpituk Klarnarong
Published: November 2021

This study included a discussion of the critical role VHVs played in the control, prevention, and monitoring of the Covid-19 pandemic in Thailand, as well as a review of related literature, with 11 of 59 topics chosen. The purpose of this study was to investigate and improve VHV competence in the control, prevention, and monitoring of the Covid-19 pandemic. The outcomes of the study indicated that VHVs were important in efficiently managing, preventing, and monitoring the Covid-19 pandemic from 2020 until the present. As a result, in addition to maximizing the potential of VHVs, it is important to be varied, knowledgeable, and up to date on current events. However, the most cost-effective utilization of resources is referred to as "Sufficiency Healthcare, High Benefit, Most Economical" when utilizing the concepts of sufficiency economics.
Knowledge, Attitude and Practice of Quilombola Women
Authors: Miranda Thamilly Joaquina Picanço , Pinheiro da Silva Marlucilena , Prudêncio Luzilena de Sousa , Dayse Santos da Mata Nely , Do Socorro dos Santos Calandrini Tatiana , Mariela da Silva Cavalcante Inara , Sampaio da Silva Karoline , Monteiro Tinale Barbosa Palheta , Gonçalves Wingred Lobato
Published: November 2021

O Cervical cancer is considered a persistent public health problem, the access to health services, as well as women's adherence to the Pap smear, is one of the main tools to change this scenario, favoring the early detection of the disease. When considering the morbidity and mortality rates, taking into account the color, it is evident that black women need a different look. Given the above, the objective of this work is to analyze the knowledge, attitude and practice of quilombola women in Amapá about the preventive examination for cervical cancer. The study has a quantitative approach, of an applied nature, of the Survey type, having as reference the Knowledge, Attitude and Practice Survey (KAP) on the PCCU exam. The field research was carried out in the Quilombo do Curiaú in the state of Amapá. The data were submitted to the SPSS version 25.0 program, for the description of the statistical results, being considered relevant the results with p<0.05, which made it possible to trace the following socioeconomic and anthropometric profile: age from 18 to 33 years old (43.75 %), Catholic (92.50%), single (52.50%), complete high school (31.35%), without paid activity (41.25%), month family income from 1 to 2 minimum wages (37 .50%) and an average of five family members (36.25%). They present weight 69.34 (Me), height 161.06 (Me), Body Mass Index (BMI) 26.685 (Me), waist circumference (WC) 86.97 (Me), hip circumference (HC) 106 .77 (Me) and CC/HC ratio index 0.8172 (Me). Thus, the study revealed that 42.50% meet the parameter considered normal for BMI and 68.75% have a low risk for the development of Chronic Non-Transmissible Neoplastic Diseases, according to CC/HC. Using the criteria proposed by the KAP survey as a reference, 26.25% had adequate knowledge, 30% had adequate attitude and 37.5% had adequate practice, demonstrating a negative proportional assessment in relation to the PCCU exam. The KAP survey was carried out, which showed that only 36.27% of the women were characterized with Adequate Knowledge, 30.00% with Adequate Attitude and 37.5% with Adequate Practice, highlighting the need for educational actions at this topic with the female quilombola population, with a view to increasing the adherence to the uterine cytopathological examination within these communities.
Solid Waste And Its Interference On The Water Quality Of The Igarapé¹ do Quarenta Educandos Basin - Manaus/Am
Authors: Soares Vieira Michael Raphael , Lopes Aixa Braga , Guerra Silvestrim Eneida , Filho Arlindo Almeida de Lima , Gianello Kamila Vitoriano , Cunha Eloiza Queiroz da
Published: November 2021

The “Igarapé do Quarenta”, a stream in Educandos basin, is categorized today as the "worst" and most polluted of the city Manaus, Amazonas, due to the accumulation of solid waste and contamination by heavy metals along its course. The main objective of this research was to verify the influence of solid waste in critical points of the Igarapé do Quarenta, on the water quality of the stream. The area of solid waste accumulation ("garbage") and the water quality in the stream and around and under the bridges of the Igarapé do Quarenta, between the springs (Armando Mendes and Zumbi neighborhoods) and the mouth (Educandos), in the Amazon "summer" and "winter"," were quantified. Water quality was evaluated at each sampling site. The macroscopic analysis demonstrated its importance for the feasibility diagnosis, finding that two of the three springs found are degraded and disturbed. The pH and electrical conductivity values in the sample sites visited, in the upper and middle, of the Igarapé do Quarenta, were very high values in relation to the maximum values recorded in a natural environment in other water streams of Manaus.
Design and calculation of heat transfer of the passive cooling modules for low-pressure hydrogen vessels
Authors: Lázár Marián , Duda Filip , Kmeťová Ľubomíra , Jasminská Natália , Hudák Šimon
Published: November 2021

This paper deals with the issue of improving the temperature management of a metal hydride tank to reduce the energy intensity of cooling. The problem of absorption and adsorption of hydrogen gas in metals, cooling of metal hydride tanks in the process of hydrogen absorption while protecting the current level of development of science and research for this area is analysed. The work also deals with numerical and experimental verification of a prototype metal hydride tank with passive cooling.
Target costing
Authors: De Lima Dias Sanailton , Tavares Filho Francisco , Luis Korzenowski André , Ozório de Souza Neto Moisés , Ramon Fonsêca Rodrigues Rafael
Published: November 2021

The implementation of a cost control system in construction companies contributes to reducing resource losses in the production process and increasing business productivity and profitability, especially when it comes to small business, which normally do not have a planning system and efficient control. Therefore, this article aims to propose a target costing model for a small construction business, concerning the efficient evaluation of its costs for the maximization of profits in proposals to provide services to public entities. A case study is used, in which data collection occurred through a questionnaire, observations of the process of preparing financial proposals, other unstructured questions, and documentary search, whose approach includes descriptive and qualitative research. The survey results revealed that the enterprise has a cost control system, but is technologically backward. Besides, the enterprise already intuitively used the concepts of target cost in preparing budgets. After evaluating the costs, a target costing model was suggested for the enterprise to use as a parameter in the bidding processes, however, it was not implemented due to the current unfavorable conditions.
Design of Image Copy-Paste Forensics System Based on Moment Invariants
Authors: Shen Jingyi , Yao Yun , Mei Hao
Published: November 2021

Copy-paste tampering is a common type of digital image tampering, which refers to copying a part of the image area in the same image, and then pasting it into another area of the image to generate a forged image, so as to carry out malicious operations such as fraud and framing. This kind of malicious forgery leads to the security problem of digital image. The research of digital image copy paste forensics has important theoretical significance and practical value. For digital image copy-paste tampering, this paper is based on moment invariant image copy paste tampering detection algorithm, and use Matlab software to design the corresponding tampering forensics system.
Flipping the Classroom
Authors: Silva Otavio Oliveira , Sousa Francyhélia Benedita Mendes , Freitas Flávio Luiz de Castro , Silva Vanessa Leite Da , Leite Jaqueline Santos C. , Costa Ariana Kelly Martins , Carvalho Concilene Régia N. Campos de , Santos Sheila Cristina Bogéa dos , Sodré Josely de Sousa
Published: November 2021

The new Coronavirus Pandemic has revealed the need for a methodological redefinition of teaching and learning attitude of teachers and students, through the pedagogical use of digital technologies. Therefore, this article aims to present reflections on the use of the Flipped Classroom methodology as a re-signifying possibility for the teaching of Philosophy in Higher Education, considering the context of remote emergency teaching. Assuming that there is a concern with the didactic-pedagogical and sociopolitical process of teaching and learning that constitutes teaching practice in the teaching of Philosophy in Brazilian Academies, the question is: what are the advantages and challenges of using the flipped classroom methodology in the process of teaching and learning Philosophy in Higher Education? For this, two fundamental aspects of the formal educational process are discussed: the first refers to the didactic-pedagogical and sociopolitical aspects of the teaching and learning process that constitute the teaching practice, as the content and didactics are emphasized. that is, the “what” and the “how to teach” and the second, it is about the need for re-signification/updating of traditional teaching in face of active methodologies. Based on the current context of remote teaching and/or hybrid teaching in Higher Education in Brazil, it is concluded that is necessary to reframe pedagogical practice in terms of the production of academic knowledge, without losing sight of the conditions in which it is produced.