bluuebunny/crossref_metadata_2025 huggingface dataset:
EXTRACTION SPECIMENS BASED ON THE BUCKTHORN BARK AND METHODOLOGICAL APPROACHES TO IDENTIFY ANTHRACENE DERIVATIVES INCLUDED
Authors: Borovikova Natal'ya Anatol'yevna
Published: July 2019

The article provides an overview of drugs based on buckthorn bark included in the State register of medicines of the Russian Federation and patented in recent years. The methods of quantitative determination of anthracenes-derived raw materials of buckthorn according to the state Pharmacopoeia of the Russian Federation XI and XIII editions and the European Pharmacopoeia are analyzed and presented in the comparative aspect. The main representatives of the anthracene-derived buckthorn are shown for a number of sources, taking into account modern phytochemical studies. The algorithm of development of a technique of spectrophotometric quantitative determination of anthracenes derivatives in buckthorn bark and extraction preparations from it is gradually presented. Studied and selected the optimal conditions of extraction: raw material grinding – 1 mm, extractant – 10% sodium hydroxide solution, the ratio of raw materials and extractant – 0.1 : 100, the extraction temperature in a water bath 100 °C, the duration of extraction – 30 minutes. The analytical maximum of 510 nm was established, a certified sample of frangul-emodin was used as a standard substance, and an experimental calculation of the specific absorption rate of frangul-emodin interaction products with an alkaline-ammonia mixture was presented. In the research we describe an optimized pharmacopoeial methodology, metrological characterizations and results of quantitative determination of the anthracene derivatives in aqueous and alcohol extracts based on the buckthorn bark. The content of the amount of anthracenes in the samples of raw materials of five domestic producers. The content varies from 4.35 to 4.85%.
OPTIMIZATION OF THE COMPOSITION OF LIGNOCELLULOSIC SUBSTRATE BASED ON PEAT AND STRAW FOR THE CULTIVATION OF MUSHROOMS PLEUROTUS OSTREATUS
Authors: Leonov Vadim Vyacheslavovich , Prontisheva Svetlana Pavlovna , Bulatov Ivan Aleksandrovich , Leonova Lyubov' Vyacheslavovna , Efanov Maksim Viktorovich , Ananina Irina Viktorovna
Published: July 2019

The aim of the study was to optimize the composition of lignocellulosic substrate based on peat and straw for growing fungi Pleurotus ostreatus. To achieve this goal, the following main tasks were set: analysis of the initial plant raw materials of peat and straw; study of the effect of an aqueous extract of peat on the growth of fungi Pleurotus ostreatus; study of the effect of the component composition of the substrate on the cultivation of oyster mushrooms.

Investigated the influence of the following relations medium : an aqueous extract of peat– 1 : 1; 1 : 2; 1 : 3; 1 : 4 and 1 : 10. The growth of fungi Pleurotus ostreatus was controlled by reducing the concentration of glucose and increasing the concentration of total protein in the culture medium. The kinetic characteristics of the growth of fungi Pleurotus ostreatus are determined from changes in the mass fractions of lignin, cellulose, easily and hardly hydrolyzed polysaccharides in substrates depending on the duration of cultivation of oyster mushrooms.

It is shown that the lignocarbon straw complex is more available for biodegradation than the lignocarbon peat complex. It was found that the addition of peat to the substrate together with straw creates optimal conditions for the growth of fungi Pleurotus ostreatus. To optimize the production of Pleurotus ostreatus, it is advisable to recommend a combined substrate with the following ratios of peat to breakage – 30 : 70% or 40 : 60%, respectively.
RECEIVING OIL FROM CLOUDBERRIES FRUITS BY SUPERCRITICAL CARBON DIOXIDE EXTRACTION
Authors: Ivakhnov Artyom Dmitrievich , Sadkova Kristina Sergeevna , Sobashnikova Alina Sergeyevna , Skrebets Tat'yana Eduardovna , Bogdanov Mikhail Vladislavovich
Published: July 2019

Comparative researches of ways of oil extraction from the fulfilled fruits of cloudberries (Rubus chamaemorus) with application of hexane and supercritical carbon dioxide as solvents are executed. Optimization is performed and optimum conditions of supercritical fluid extraction of oil are defined with use of central composite design of 2nd order. Pressure of carbon dioxide of 350 atm, temperature 85 °C, duration of extraction of 80 min are the optimum conditions of carrying out of the process. The yield of oil is 9.0%. Quality key indicators of the received oil were defined. The difference between the oil received by the SKF-CO2 method and the oil received by hexane extraction consists in improvement of organoleptic properties, the raised share of the combined fatty acids at decrease of a share of the free acids and high content of unsaturated fatty acids. It is shown that supercritical carbon dioxide can be an alternative to the hydrocarbons which are traditionally used for these purposes.
Variable Features of Juvenile Polyposis Syndrome With Gastric Involvement Among Patients With a Large Genomic Deletion of BMPR1A
Authors: Lieberman Sari , Beeri Rachel , Walsh Tom , Schechter Menachem , Keret Dan , Half Elizabet , Gulsuner Suleyman , Tomer Ariela , Jacob Harold , Cohen Shlomi , Basel-Salmon Lina , Mansur Mahmud , Berger Rachel , Katz Lior H. , Golomb Eliahu , Peretz Tamar , Levy Zohar , Kedar Inbal , King Mary-Claire , Levy-Lahad Ephrat , Goldberg Yael
Published: June 2019

OBJECTIVES:

Loss-of-function mutations of BMPR1A cause juvenile polyposis syndrome (JPS), but large genomic deletions in BMPR1A are rare, reported in few families only, and data regarding the associated phenotype are limited.

METHODS:

We investigated clinical features and genomic data of 7 extended seemingly unrelated families with a genomic deletion of the entire coding region of BMPR1A. We defined mutation size, mutation prevalence, and tumor pathogenesis using whole-genome sequencing, targeted genotyping, and haplotype analysis.

RESULTS:

Patients with JPS from 7 families of Bukharin Jewish ancestry carried a deletion of 429 kb, encompassing the BMPR1A coding sequence and 8 downstream genes. Haplotype analysis and testing controls identified this as a common founder mutation occurring in 1/124 individuals of Bukharin origin. Tumor testing did not demonstrate loss of heterozygosity. Among carriers, JPS was almost fully penetrant, but clinical features varied widely, ranging from mild to very severe, including pan-enteric polyps, gastritis, and colorectal, esophageal, and testicular cancer, and carriers with phenotypes, which would not have raised suspicion of JPS.

DISCUSSION:

The phenotype in this large cohort was extremely variable, although all carriers shared the same variant and the same genetic background. New observations include a preponderance of adenomatous rather than juvenile polyps, possible association with testicular cancer, and unexpected upper gastrointestinal involvement.
Un laboratorio de cambio social: los años sesenta latinoamericanos en clave comparada. Una propuesta para su enseñanza
Authors: Cerdá María Celeste , Mera María Noel
Published: June 2019

A fines de los años sesenta, México y Argentina atraviesan procesos de alta movilización social, la emergencia de la juventud como actor social, referencias comunes (no sin tensiones) a los movimientos de mayo francés que constituyen similitudes relevantes para un abordaje en clave comparada. En diálogo con los aportes de la investigación didáctica nos proponemos recuperar esta perspectiva comparada para analizar el “mayo argentino” y “el mayo mexicano”. Entendemos que nociones claves de esta forma de pensamiento se ven potenciadas a partir de estudios comparados al poner en discusión dimensiones tales como lo local y lo global en los procesos históricos (escalas), lo sincrónico y diacrónico en el desarrollo del conflicto (temporalidad), las estructuras y coyunturas (causalidad) en el estallido de acontecimientos que conmueven los cimientos políticos y/o culturales de ambos países a fines de la década del sesenta. Al mismo tiempo, posicionadas en la didáctica crítica prestaremos especial atención a las categorías con que esas experiencias del pasado reciente han sido nombradas e interpretadas. “Cambio social”, “conflicto”, “derrota”, “tragedia”, “vencidos”, “futuro”, son parte de esas narrativas que nos proponemos revisitar con el propósito de construir una propuesta de enseñanza alternativa que promueva la formación del pensamiento crítico y creativo de los alumnos.
González, P. (2018). La enseñanza de la historia en el siglo XXI. Saberes y prácticas
Authors: Coudannes Mariela
Published: June 2019

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Sistematización de la experiencia del Foro de Jóvenes por una Latinoamérica integrada, un espacio de diálogo intercultural en la ciudad de Rosario
Authors: Capeletti Dalila Emilse
Published: June 2019

Este artículo presenta una sistematización de la experiencia del Foro de Jóvenes por una Latinoamérica integrada desarrollado entre los años 2012 y 2016 y llevada adelante por la Universidad Nacional de Rosario. El mismo trata de una experiencia extensionista en integración sociocultural con las comunidades de inmigrantes latinoamericanos residentes en la ciudad. Con este objetivo, en primer lugar, daremos cuenta de las condiciones de contexto y las situaciones particulares que posibilitaron el desarrollo de la práctica. Luego, describiremos las acciones llevadas adelante con las comunidades de inmigrantes latinoamericanos residentes en Rosario y, finalmente, abordaremos los aprendizajes adquiridos durante la experiencia por los estudiantes involucrados en la práctica. A modo de cierre, reflexionaremos críticamente sobre las posibilidades de pensar y accionar una nueva práctica transformadora.
Salud mental y literaturas no realistas: aportes de la extensión a la investigación
Authors: Cabrera Rodriguez Lucas , Pagano Artigas María Estefanía , Vázquez Andrés
Published: June 2019

El presente artículo busca reflexionar sobre los aportes de la extensión a la investigación mediante la articulación de la salud mental y las literaturas no realistas a partir del Espacio de Formación Integral (dispositivo que involucra actividades de extensión, enseñanza e investigación): “Taller abierto de lectura, interpretación y creación en torno a literaturas no realistas, insólitas y fantásticas en el Hospital Vilardebó”, de la Facultad de Humanidades y Ciencias de la Educación de la Universidad de la República. Se intenta reflejar cómo dicha experiencia extensionista que promueve integralidad, aporta, contribuye y colabora a repensar la investigación “tradicional” que se percibe del Grupo de Investigación Raros y Fantásticos en la Literatura Uruguaya. Teoría, Crítica e Historia (1963–2004) y así posibilitar una nueva forma de investigar: acompañada de la extensión.
Hacia un pensar colectivo. Una experiencia de extensión universitaria en las ruralidades uruguayas
Authors: Quintana Mariana , Capurro Pablo , González Fajardo Daniel
Published: June 2019

El siguiente artículo relata una experiencia de trabajo acerca del fomento y promoción del asociativismo en la localidad de Paso Centurión (Cerro Largo), Uruguay. Dicho proyecto es fruto de la financiación de Proyectos Estudiantiles de Extensión Universitaria de la Comisión Sectorial de Extensión y Actividades en el Medio de la Universidad de la República.El desarrollo de este proyecto se llevó a cabo en las modalidades de encuentros y talleres con la finalidad de discutir conceptualmente el asociativismo como forma de organización. Este trabajo fue realizado en conjunto con dos grupos de la zona e instituciones referentes en la temática y fue posible así identificar las potencialidades y los desafíos de estos emprendimientos en la zona. Sus resultados arrojan la necesidad de reflexionar sobre la estrategia del trabajo asociado en ámbitos rurales, el ecoturismo, las políticas de conservación ambiental y el rol de las instituciones públicas en el fortalecimiento de la autogestión.
BİST KİMYA, PETROL KAUÇUK VE PLASTİK ÜRÜNLER SEKTÖRÜNDEKİ İŞLETMELERİN FİNANSAL PERFORMANSLARININ HİBRİD ÇKKV YAKLAŞIMI ÇERÇEVESİNDE DEĞERLENDİRİLMESİ
Authors: ÇANAKÇIOĞLU Mustafa
Published: July 2019

Bu çalışmada Borsa İstanbul (BIST) imalat sanayinde yer alan kimya, petrol kauçuk ve plastik ürünler sektöründe yer alan firmaların oran analizi yaklaşımı ile birbirleriyle karşılaştırmalı finansal performans analizi yapılmıştır. Çalışma kapsamında 30 işletmenin 2013-2017 tarihleri arasındaki temel mali tablolardan elde edilen 10 finansal oran kriteri kullanılmıştır. Elde edilen veriler “Çok Kriterli Karar Verme” (ÇKKV) yöntemlerinden Entropi ve Gri İlişkiler Analiz (GİA) ile değerlendirilmiştir. Belirlenen seçim kriterlerinin ağırlıkları Entropi tekniği kullanılarak hesaplanmıştır. Ardından GİA yöntemi kullanılarak karar seçeneklerinin göreli önem değerleri hesaplanmış, firmalar her yılın performans değerlerine göre sıralandırılmıştır. Son olarak Borda metodu kullanılarak firmalar tüm yıllara göre yeniden sıralandırılmıştır.
TÜKETİCİ ETNOSENTRİZMİ VE ÜLKE MENŞEİ ETKİSİNİN YABANCI MARKALI ÜRÜN SATIN ALMA NİYETİ ÜZERİNE ETKİSİ
Authors: AYDOĞAN Sibel
Published: July 2019

Tüketici etnosentrizmi (etnik merkezcilik), tüketicilerin bireysel özelliklerine ve onların niyetlerine, tercihlerine, satın alma davranışlarını etkileyen tutumlarına odaklanır. Ürünün menşe ülkesi ve dolayısıyla menşe ükenin imajı satın alma aşamasında tüketici algısında olumlu ya da olumsuz çağrışımlar yapabilmekte ve bu da satın alma kararını etkileyebilmektedir. Eğer ürünün üretildiği ülke tüketici zihninde olumlu çağrışımlar yaratıyorsa bu durum ürünün imajının da olumlu olmasına neden olmakta ve satın almayı pozitif yönde etkilemektedir. Bu çalışmanın temel amacı öncelikle tüketicilerin etnosentrizm derecesini belirlemektir. Tüketici etnosentrizmi ile menşe ülkenin tüketicilerin yabancı markalı ürünlere yönelik satın alma niyetleri üzerindeki etkisinin değerlendirilmesi ise çalışmanın bir diğer amacıdır. Bu bağlamda kolayda örnekleme yöntemi ile 605 kişiye ulaşılmıştır. Çalışmaya göre, tüketici etnik merkezcilik ortalaması, orta düzeyde eğilimi gösteren 49,17 sayısıdır. Ülke Menşei Etkisi ile Tüketici Etnosentrizmi arasında pozitif yönlü bir ilişki görülmüştür. Tüketici Etnosentrizmi ile yabancı marka çay satın alma niyeti arasında ise negatif yönlü bir ilişki vardır.
SPONTANICZNOŚĆ CZY ODGÓRNE STEROWANIE? FUNKCJONOWANIE ZJAWISK SPOŁECZNYCH POWIĄZANYCH Z KULTURĄ MASOWĄ NA PRZYKŁADZIE FANDOMU GWIEZDNYCH WOJEN
Authors: WERNER Wiktor , TRZOSS Adrian
Published: June 2019

The article is devoted to the issue of the impact of the new media on the mass culture. Authors have explored community portals using modern methods of quantitative and qualitative data analysis. The results show that belief in the more democratic, egalitarian character of the new media compared to the traditional corporate model of the mass-media industry may be a delusion as large mass media corporations have also had a great impact on the functioning of social networking sites.
,,DLA JEDI CZAS NASTAŁ TAKŻE, BY JEŚĆ”. SCENY UCZTY W SADZE GWIEZDNE WOJNY
Authors: BARBARZAK Dawid
Published: June 2019

Feast scenes from the main Star Wars episodes play an important role the creation of the plot and characters. In the paper I divide them into three types. In the first part I discuss the scenes in which a feast or a meal is a pretext for the dialogues revealing the characters’ past (the conversation between Luke and his uncle) or predict their future (little Anakin and Qui-Gon during the dinner; Anakin and Padmé’s conversation predicting their fall). In the second part I present eating scenes through the authors create or underline the characteristic features of the protagonists (comism of Jar Jar Binks and Chewbacca; Jabba’s gluttony; dehumanization of the black characters by the fact that they lack any contact with food) or build their social status (Rey’s scavenger meal; feasts at tha palaces of Jabba and Amidala; Jedi master’s ascetic meal on Dagobah; clones’ canteen). To analyse the scenes I use theories developed by food anthropologists (Mary Douglas, Claude Levi-Strauss, and Katarzyna Łeńska-Bąk) and make references to classical mythology and the Bible. In the last part I raise questions about consumer’s the identity of the character who eats juxtaposing devouring and eating scenes (why are Eworks considered humanoids whereas Wampa and Rancor are considered monsters since they all eat human flesh?).
,,BIERZESZ CZTERY LUB PIĘĆ NUT, JEDNĄ WYRZUCASZ, JEDNĄ PRZESUWASZ…”, czyli temat główny z Gwiezdnych wojen i Marsz imperialny jako standardy muzyki filmowej oraz ich wpływ na kulturę popularną
Authors: SKORUPSKI Patryk
Published: June 2019

Zdjęcia z tego zdjęcia są i są z nim związane. Wies jest z muzyką i melodiami. Większość z nas może nucić „Oda do radości”, „Für Elise” lub… „Imperial March” z „Gwiezdnych wojen”. Jaka jest najsilniejsza jakość muzyki z tej sagi? Dynamizm? Prostota? A może ton instrumentów? Spróbuję znaleźć powód.
17 WRZEŚNIA 1939 ROKU NA KRESACH WSCHODNICH W PROPAGANDZIE RADZIECKIEJ ORAZ WE WSPÓŁCZESNYM SPOJRZENIU POLAKÓW I BIAŁORUSINÓW
Authors: KULESZEWICZ Anna
Published: June 2019

On September 17, 1939, on the strength of the Ribbentrop-Molotov Pact established on August 23, 1939, Soviet troops carried out armed aggression on the Second Polish Republic without official declaration of war. As a result – Polish territories were divided between Germany and the USSR: the eastern territories of the country were influenced by the Kremlin and part of the eastern territories of the Second Polish Republic was incorporated into the Belorusian Soviet Socialist Republic. All war and aggressive activities required not only a deliberate military plan, but also the preparation of an appropriate propaganda ground: propaganda was a tool for creating the necessary background among the masses of the population and on the international arena. Propaganda was used by both the Polish and the Soviet sides: before, during and after the war. Before the war, Poles focused more on Nazi Germans, although some circles of the intelligentsia showed great interest in Soviet Russia. As for current awareness and official interpretation in relation to the events of September 17, 1939, they are considered an act of aggression. Propaganda has always been a strong weapon in the hands of the Soviets. Using this tool, they tried to create a ground and “justify” the aggression against Poland, a myth about the necessity of freeing the oppressed Ukrainians and Belarusians was invented, repeated until the collapse of the USSR. Currently, it is still possible to observe suchan interpretation in Belarus, although the situation is slowly changing, aiming at the recognition of historical truth.
POLITYKA WŁADIMIRA PUTINA A KWESTIA ROSYJSKIEJ TOŻSAMOŚCI NARODOWEJ
Authors: KOT-WOJCIECHOWSKA Joanna
Published: June 2019

The article deals with the issue of shaping the national identity in Russia after the collapse of the USSR. The author analyzes the significance of religious phenomena, and in particular Orthodox Christianity in the creation of new forms of collective identity.
Rola kompetencji poznawczych w demokratycznych systemach politycznych
Authors: Chmielewski Adam Janusz
Published: June 2019

Wychodząc od normatywnego ideału demokracji, ugruntowanego w inkluzywnym rozumieniu podmiotu demokracji, autor twierdzi, że w większości koncepcji demokracji kompetencje poznawcze są postrzegane jako podstawowy wymóg upoważniający do udziału w sprawowaniu władzy politycznej. Współczesna debata nad właściwym rozumieniem demokracji koncentruje się na próbach rozstrzygnięcia dylematu między ideą szerokiego uczestnictwa ludu w sprawowaniu władzy a ideałem deliberacyjnym, który zakłada, że władza w tych systemach winna być powierzona wyłącznie osobom o odpowiednich kompetencjach poznawczych. Autor analizuje główne elementy stanowisk kognitokratycznych i wskazuje na potencjalne zagrożenia wynikające z przypisywania kompetencjom poznawczym wyróżnionej roli. Stanowiska tego typu, zarówno w wersji uniwersalistycznej, jak i elitarnej, są według autora obciążone błędem kognitokratycznym. W opozycji do nich autor argumentuje na rzecz tezy o podstawowej roli umiejętności politycznej w systemach demokratycznych. Wskazuje również, że punktem wyjścia do rozważań nad znaczeniem tego pojęcia winien być normatywny ideał demokracji inkluzywnej, zakładający powszechność zdolności do kształtowania umiejętności politycznej oraz przekonanie, że owa zdolność może ulegać aktualizacji w samym procesie aktywności politycznej.
Risk factors of regional lymph node metastasis in patients with cervical cancer
Authors: Wu Chunchun , Li Lichun , Xiao Xue , Sun Anyi , Lin Wenji , Li Ailu
Published: June 2019

Objectives

To explore the risk factors related to regional lymph node metastasis in cervical cancer and analyze the value of independent risk factors in predicting regional lymph node metastasis.

Methods

We retrospectively analyzed the clinical data of 699 patients who underwent surgery for stage IB1–IIA2 cervical cancer in Quanzhou First Hospital affiliated to Fujian Medical University from 2010 to 2016. The patients were divided into metastasis (n = 92) and non-metastasis (n = 607) groups based on the postoperative pathology of regional lymph node status. The relevant clinicopathological features of the metastasis and non-metastasis groups were compared through variance analysis and chi-square tests. Logistic regression was adopted to screen relevant independent risk factors of regional lymph node metastasis.

Results

In univariate analysis, International Federation of Gynecology and Obstetrics (FIGO) stages, serum squamous cell carcinoma antigen (SCC-Ag), histological type of squamous carcinoma and maximal tumor diameter were related factors for lymphatic metastasis in patients with cervical cancer. In multivariate analysis, SCC-Ag and histological type of squamous carcinoma were independent prognostic factors for lymphatic metastasis in patients with cervical cancer. Pre-treatment SCC-Ag serum levels, as a predictor of lymph node metastasis of cervical cancer, revealed a sensitivity of 62.07% (95% confidence interval (CI): 51.03–72.62%), specificity of 65.15% (59.07–70.89%), and area under the receiver operating characteristic (ROC) curve of 0.69 (95% CI: 0.61–0.76).

Conclusions

Cervical cancer patients whose pathological type is squamous carcinoma with high levels of SSC-Ag pre-operation are more likely to be diagnosed with regional lymph node metastasis. Standardized lymph node dissection should be implemented during operation.
Values and Attitudes in Banat Multiethnic Communities
Authors: Dabu Ileana Simona
Published: July 2019

The Banat area is considered an area of interculturality and multilingualism, an area where there is an interference of cultures, a continuous dialogue between cultures and spiritualties. Banat, being a multicultural and multiethnic space, is a model of harmonious coexistence between the many ethnic groups that make it up. In the present research we have aimed at identifying the individual values of the inhabitants of the studied communities and the attitudes towards the others (Romanians, Serbs, Hungarians, Germans, Bulgarians and other ethnic groups), and also their attitudes towards work, land, church, trust in state institutions and traditional occupations.
Ex-Offender Reintegration and Sustained Peace in the Niger Delta Region of Nigeria: Adopting a Socio-Economic Change Model Approach
Authors: Ubleble Benjamin A. , Agomoh John M. , Chovwen Anthony
Published: July 2019

The Niger Delta of Nigeria rich in oil and gas resources has been plagued with series of armed conflicts characterised by massive youth restiveness. The peaceful coexistence of people in the region is often affected by the nature of oil and gas business determined by the political economy of the Nigerian state. By the statute of the Federal system of Government in Nigeria, all resources within the territorial boundary of the country belong to the Federal Government. The Government then pays a certain 13% derivation fund to the resource bearing states for development. The Federal Government equally sees to the development of the region through its statutory Agencies such as the Niger Delta Development Commission. All these efforts are yet to bring about infrastructural development and human capacity needs of the region. A consequence of this is the armed militancy and cult related violence that has engulfed the region. In this paper, an attempt is made to analyse the socioeconomic requisitions of a reintegration programme for ex-offenders seeking re-entry into mainstream society. An interventionist approach is recommended with effective monitoring and evaluation system for a socioeconomic reintegration of ex-offenders in the Niger Delta region of Nigeria.
Elevated levels of soluble PD-L1 are associated with reduced recurrence in papillary thyroid cancer
Authors: Aghajani Marra Jai , Roberts Tara Laurine , Yang Tao , McCafferty Charles Eugenio , Caixeiro Nicole J , DeSouza Paul , Niles Navin
Published: June 2019

To date, no research evaluating the predictive capabilities of soluble programmed cell death-ligand 1 (sPD-L1) in thyroid cancer patients has been performed. We aimed to investigate the prognostic significance of sPD-L1 expression in papillary thyroid cancer (PTC) and to evaluate the association between sPD-L1 levels with tumoural PD-L1 expression and patient outcomes. Pre-treatment levels of serum and plasma sPD-L1 were measured by ELISA in 101 PTC patients. Tissue microarrays were stained with an anti-PD-L1 antibody, clone SP263 (Ventana). The median serum sPD-L1 concentration in PTC patients was significantly higher compared to healthy controls (P = 0.028). An increased incidence of extrathyroidal extension was significantly associated with an elevated serum sPD-L1 level (P = 0.015). Patients with high serum sPD-L1 levels had significantly shorter median disease-free survival (DFS) as compared to those with low sPD-L1 levels (P = 0.011). Following multivariate analysis, serum sPD-L1 was the only statistically significant predictor for DFS. Patients with both positive serum and tumoural PD-L1 expression had a significantly shorter DFS than those in any other subgroup (P = 0.007). Our study is the first to confirm that sPD-L1 concentration is significantly associated with patient outcome in PTC. Soluble PD-L1 may provide clinicians with a non-invasive biomarker that can lessen dependence on tissue biopsies and diagnose aggressive thyroid cancers at a more treatable stage.
Inverse problem for $2b$-order differential equation with a time-fractional derivative
Authors: Lopushansky A.O. , Lopushanska H.P.
Published: July 2019

We study the inverse problem for a differential equation of order $2b$ with the Riemann-Liouville fractional derivative of order $\beta\in (0,1)$ in time and given Schwartz type distributions in the right-hand sides of the equation and the initial condition. The problem is to find the pair of functions $(u, g)$: a generalized solution $u$ to the Cauchy problem for such equation and the time dependent multiplier $g$ in the right-hand side of the equation. As an additional condition, we use an analog of the integral condition $$(u(\cdot,t),\varphi_0(\cdot))=F(t), \;\;\; t\in [0,T],$$ where the symbol $(u(\cdot,t),\varphi_0(\cdot))$ stands for the value of an unknown distribution $u$ on the given test function $\varphi_0$ for every $t\in [0,T]$, $F$ is a given continuous function.

We prove a theorem for the existence and uniqueness of a generalized solution of the Cauchy problem, obtain its representation using the Green's vector-function. The proof of the theorem is based on the properties of conjugate Green's operators of the Cauchy problem on spaces of the Schwartz type test functions and on the structure of the Schwartz type distributions.

We establish sufficient conditions for a unique solvability of the inverse problem and find a representation of anunknown function $g$ by means of a solution of a certain Volterra integral equation of the second kind with an integrable kernel.
Note on bases in algebras of analytic functions on Banach spaces
Authors: Chernega I.V. , Zagorodnyuk A.V.
Published: July 2019

Let $\{P_n\}_{n=0}^\infty$ be a sequenceof continuous algebraically independent  homogeneous polynomials on a complex Banach space $X.$ We consider the following question: Under which conditions polynomials $\{P_1^{k_1}\cdots P_n^{k_n}\}$ form a Schauder (perhaps absolute) basis in the minimal subalgebra of entire functions of bounded type on $X$ which contains the sequence $\{P_n\}_{n=0}^\infty$? In the paper we study the following examples: when $P_n$ are coordinate functionals on $c_0,$ and when $P_n$ are symmetric polynomials on $\ell_1$ and on $L_\infty[0,1].$ We can see that for some cases $\{P_1^{k_1}\cdots P_n^{k_n}\}$ is a Schauder basis which is not absolute but for some cases it is absolute.
Efecto de un programa adaptado de educación física en niños con discapacidad auditiva sobre la coordinación motora
Authors: Ochoa-Martínez Paulina Yesica , Hall-López Javier Arturo , Carmona López Abel Alberto , Morales Ramírez Mara Michell , Alarcón Meza Edgar Ismael , Sáenz-Lopez Buñuel Pedro
Published: June 2019

Objetivo: evaluar el efecto de un programa de educación física adaptado en escolares con discapacidad auditiva sobre el cociente motor.

Método: el diseño del estudio fue cuasiexperimental, con muestreo por conveniencia, participando treinta y ocho niños con una edad promedio de 7.4±0.9 años, diagnosticados con debilidad o pérdida auditiva, de dos escuelas de la ciudad de Mexicali, Baja California. México. Los participantes fueron divididos aleatoriamente en un grupo experimental (n=23) y otro control (n=15), a los cuales se les evaluó el cociente motor mediante el test de coordinación corporal para niños KTK (Körperkoordinationstest für Kinder de Kiphard y Schiling), por sus siglas en alemán, mediante las pruebas: desplazamientos en equilibrio de espaldas, saltos monopódales, saltos laterales y transposición sobre plataforma. El programa se realizó durante 4 meses, 5 veces por semana, con una duración de 50 minutos por sesión, comunicándose con los alumnos mediante el lenguaje de señas mexicano y realizando una serie de tareas que enfatizaran la coordinación motora.

Resultados: al comparar los resultados entre grupos de la variable cociente motor, con el análisis de varianza (ANOVA) mixtas 2 x 2 se observó una interacción doblemente significativa entre los grupos y las mediciones (p = 0.01), los porcentajes de cambio (Δ %) fueron 26 % del grupo experimental y 6.5 %. del grupo control (Δ %).

Conclusión: se establece que la aplicación de un programa de educación física adaptado durante cuatro meses, mejora la coordinación motora en niños con discapacidad auditiva.
Reflexiones en torno al fracaso escolar
Authors: Morales Ramírez María Ester , Salas Natalia
Published: July 2019

Este artículo presenta algunas reflexiones sobre un aspecto de vital trascendencia en el contexto educativo actual: el fracaso escolar.Para ello se retoman ideas, conceptos y experiencias de diversas fuentes, construyendo, desde un horizonte teórico algunas nociones involucradas activamente en esta problemática social.Para facilitar su lectura, se divide en varios apartados, en donde se retoman temas tales como Conceptualización del fracaso escolar, magnitud del problema en Costa Rica, aspectos asociados y variables que se derivan de lo observado dentro del sistema educativo, familiar, social y propio de estudiante. Dichos temas formulan postulaciones reconocidas y a la vez innovadoras sobre la necesidad de visualizar la problemática desde una perspectiva multicausal y a la vez integral, proponiendo un trabajo interdisciplinario, de cara a un mundo educativo cambiante y lleno de nuevos retos.
Use of the Statistical Comparison Method in a Company's Financial Status Analysis
Authors: Mackevičius Jonas , Tamulevičienė Daiva , Valkauskas Romualdas
Published: July 2019

General economic, mathematical and heuristic study methods were used when analyzing the financial status of companies. In practice, the comparison method is the most widely applied one of all the general economic research methods. When it is applied, the actual indicators (absolute and relative) are compared to the ones planned inside the company; the indicators of the company are compared with the average ones of the industry or the best ones of other companies; indicators of different periods are compared. However, until now, the comparison method has barely been applied in practice using the averages of certain indicators and especially the multidimensional ones. The aim of the article is to develop a methodology for applying the statistical comparison method based on the calculation and evaluation of the multidimensional average. For achievement of the aim were used research methods: analysis of scientific literature, information collection, aggregation, detailing and summarizing. The article analyzes the significance, advantages and disadvantages of the traditional comparison method. The methodology for the comparison method based on the calculation of the multidimensional average and their comparison is proposed in the article. A concrete example of how to apply the comparison method using the multidimensional average calculation method to assess the financial position of companies is provided.
Attendance Recognation by Using Smart Meter Based On IoT Study Case : FST UIN Jakarta
Authors: Fahrianto Feri , Suseno Hendra Bayu , Reza Alfatta
Published: June 2019

State Islamic University Syarif Hidayatullah Jakarta as rapidly growing university toward world-class research university placed in the edge of Jakarta has academic information centre running by Pustipanda (The Center of Information Technology and Database). The acadmic information system (AIS) has been used for recording an academic activity in university for almost a decade, this information system has a functionality for detecting the lecturer attandancity, but the attendance system needs to be input by admin. In this research, the system to detect attendancity from lecturer is build and synchronize to universisty academic information system.  Internet of Things, based on ITU-T 2015, some objects are able to transmit data among object by using Internet connection. It means by this technology the Internet used has been widely changed, from human to machine communication now also become machine-to-machine communications. By using this technology a small object or device is able to implement into electrical system to detect an activity occured in the room. Things implemented in the room are able to monitor which electronic device is active and motion of moving objects, also the position of objects. The communication connection between smart phones and acces point in the class room is also monitored in order to identify the lecturer identity.
Apresentação
Authors: De Souza Draiton Gonzaga
Published: July 2019

O presente número da revista Veritas reúne textos relacionados, quase em sua maioria, à filosofia de língua alemã, que em 2004 merece, sem dúvida, destaque especial. Neste ano comemoramos o bicentenário da morte de Immanuel Kant (1724-1804). No mundo inteiro, realizar-se-ão importantes eventos dedicados à filosofia de um dos maiores gênios da história do pensamento ocidental. Também a Seção Rio Grande do Sul da Sociedade Kant Brasileira www.pucrs.br/pgfilosofia/kant, presidida pelo Prof. Dr. Nythamar de Oliveira (PUCRS), promoverá um Colóquio sobre o filósofo de Konigsberg em maio, em Porto Alegre, juntamente com o Instituto Goethe, reunindo renomados especialistas no pensamento kantiano no Brasil e da Alemanha. Este evento insere-se nas atividades que antecedem o X. Congresso Internacional Kant, previsto para a primeira semana de setembro de 2005, em São Paulo, sob a presidência do Prof. Dr. Valério Rohden.Ainda em 2004, dois professores do Programa de Pós-Graduação em Filosofia da PUCRS também comemorarão datas especiais: Prof. Dr. Ernildo Stein festeja seus 70 anos, em julho, e Prof. Dr. Hans-Georg Flickinger completa 60 anos, em agosto. Estes dois eminentes professores dedicam grande parte de sua atividade intelectual à filosofia alemã, num diálogo crítico permanente com autores como Hegel, Husserl, Heidegger, Marx e Gadamer.
Cuidado de si e escolha ética em Marco Aurélio
Authors: Gazolla Rachel
Published: July 2019

Este estudo visa expor suas noções básicas do pensamento do estóico Marco Aurélio que nos falam ainda de perto na modernidade: o pertencimento a si mesmo e o cuidado de si. Elas estão intimamente relacionadas com a physis e a Ética estóicas. Pretende-se mostrar o aparente paradoxo da afirmação estóica sobre nossas ações éticas fundarem-se na determinação cósmica, ao mesmo tempo em que há uma abertura possível para deliberar particularmente a partir desta determinação universal.
Problemas fundamentais da filosofia do direito de Hegel
Authors: Jaeschke Walter
Published: July 2019

O presente trabalho aborda a forma como Hegel coloca a questão da relação entre razão e história, entre direito natural e história, na Filosofia do Direito. Após a apresentação dos antecedentes dessa relação. Tematiza-se o desenvolvimento da problemática nos textos de Hegel.
Apresentação
Authors: De Souza Ricardo Timm
Published: July 2019

O presente número de VERITAS apresenta como linha condutora principal do conjunto de seus textos uma variedade de questões, amplas ou pontuais, de alta relevância filosófica, relacionadas a temas da Ética moderna e contemporânea. Também a Estética mereceu a atenção, por parte de vários autores, recebeu exatamente a temática – de grande atualidade nos estudos de ponta tanto da Ética como da Estética – da articulação entre estes dois campos de investigação filosófica. Além disso, e em referência evidente ao universo da Ética e da Estética, também o tema da subjetividade mereceu a atenção de vários dos textos que constituem este número da Revista.Temos a lamentar profundamente o falecimento do Ir. Nilo Berto, Diretor de VERITAS desde 1979, ocorrido quando o presente número se encontrava em elaboração. Ir. Nilo, já com avançada idade, disponibilizava continuamente ao Editor, organizadores e autores o somatório de sua vasta experiência e incansável cuidado na confecção de cada número da Revista, marcando definitivamente a história deste que é um dos mais tradicionais periódicos da área da filosofia no Brasil. À memória do Ir. Nilo é dedicado o presente número.
Os territórios da subjetividade artística a partir do olhar da modernidade
Authors: Da Silva Ursula Rosa
Published: July 2019

Este artigo apresenta uma leitura da estética contemporânea a partir de elementos instaurados pelo olhar da Modernidade, tais como o caráter efêmero e uma nova forma de percepção, inquietante e acelerada. Assim, os territórios da arte demonstram que ela revela o Eu e seus vários espaços.
Arte e educação ético-política e religiosa na república de Platão
Authors: Paviani Jayme
Published: July 2019

Platão, na República, condena a arte. Essa condenação, inicialmente, é de natureza pedagógica e moral e não estética, no sentido moderno da teoria estética e, em segundo lugar, por motivos metafísicos. No contexto de uma reforma ético-política e de uma reforma educacional, podemos nos indagar se os argumentos de Platão atingiriam hoje a poesia de Fernando Pessoa e a pintura de Pablo Picasso. As acusações contra a arte fundam-se em dois tipos de argumentos. Nos livros II e III, Platão afirma e demonstra a incapacidade dos poetas gregos de atender as exigências das faculdades da alma. No livro X, a condenação da poesia e da pintura tem como base o fato de a arte ser puramente imitação, ilusão e, assim, opor-se à teoria das ideias.
Os limites da bioética em Hans Jonas e os limites do principialismo
Authors: Pelizzoli Marcelo Luiz
Published: July 2019

Trata-se de, ao expor o andamento de nossa pesquisa em Fundamentos da Bioética, apontar os limites das (bio)éticas tradicionais, no caso exemplar do Principialismo, para então investigar a base da proposta de Hans Jonas como alternativa de fundamento contemporâneo para a Bioética – a sua humanização face à civilização tecnocêntrica.
Hermenêutica e : Subjetividade: Uma discussão a partir de Schleiermacher e de Paul Ricoeur
Authors: Ruedell Aloísio
Published: July 2019

O texto trata da relação entre hermenêutica e subjetividade, examinando, em particular, a sua configuração no pensamento de Friedrich Schleiermacher e de Paul Ricoeur. A sua discussão situa-se no contexto do giro linguístico, destacando, entretanto, uma concepção diferenciada da linguagem, transformada ela mesma em objeto de interpretação. É uma concepção diferenciada que permite e requer a hermenêutica e a sua relação com a subjetividade. O que orienta toda a discussão é a tese de que a hermenêutica, enquanto arte de compreensão e de interpretação, é produto da modernidade, mas é também a sua superação.
Proceso metodológico usado en el registro de las gráficas rupestres del Monumento Nacional El Farallón (MNEF)
Authors: Rojas María Fernanda
Published: July 2019

Este artículo detalla la metodología utilizada en el proceso de registro de las gráficas rupestres del Monumento Nacional El Farallón (MNEF), ubicado en Cedros de Cañas, como una alternativa viable que puede ser replicada en sitios patrimoniales de valor arqueológico. Además presenta un breve análisis de algunas de las gráficas rupestres que se encuentran en esa pared rocosa, asociadas a la fauna local.
Construyendo la “identidad salvadoreña” a través de la arqueología nacional, desde la revista Anales del Museo Nacional de El Salvador, 1903-1911
Authors: Erquicia José Heriberto
Published: July 2019

Desde la creación de los estados nacionales, los gobernantes e intelectuales centroamericanos se dieron a la tarea de edificar una nación inculcando en sus pobladores un sentido de pertenencia y adhesión a la nueva comunidad imaginada, a través de la escuela, el museo, las revistas y los periódicos, entre otros elementos. Es por ello que, en los albores del siglo XX, nacía la revista Anales del Museo Nacional, con la meta de publicar las conferencias, los artículos de interés de la prensa internacional, las nuevas adquisiciones de objetos, los nombres de los donantes, los resultados de las exposiciones nacionales y demás actividades académicas y científicas que gestionaba dicho Museo Nacional. Así, desde que aparece a la luz pública el primer número de la revista Anales del Museo Nacional de El Salvador, el tema de la arqueología nacional jugaría un papel importante en el proceso de construcción de la “identidad salvadoreña”, pues esta quedaría llena discursos patrios y nacionalistas.
La casa de adobe, un referente cultural de la identidad costarricense
Authors: Campos Murillo Gabriela
Published: July 2019

El desconocimiento de los referentes culturales propicia la fijación de un estereotipo; por consiguiente, es importante adquirir herramientas para la comprensión cultural y la validación de los referentes. La casa de adobe, para los costarricenses, es un elemento constitutivo de la conciencia colectiva y parte de la identidad que evidencia su vitalidad cultural; pero requiere de teorías como: habitar, paisaje, inteligencias múltiples, reflexión, comprensión y creatividad; así se validarán las imágenes visibles y las no visibles, de tal forma que una casa de adobe se convierte en “terruño”, en habitar, en existencia, en realidad, en síntesis, en una verdad en sí misma.
Nuevo mundo, diversidad y gastronomía del Caribe sur costarricense
Authors: Jiménez Carolina
Published: July 2019

La comida caribeña incluye múltiples variedades gastronómicas, emparentadas por técnicas culinarias y una larga lista de ingredientes comunes, adoptados para la preparación de los alimentos usados tanto para eventos especiales, como en la nutrición cotidiana. Se realiza un recorrido histórico por las influencias caribeña y se ofrecen testimonios y recetas.
El museo+UCR: una realidad en concreto. 5 años de celebración, 15 años de trabajo continuo
Authors: Arias Quirós Ana Cecilia , Barboza Retana Félix , Zavaleta Ochoa Eugenia
Published: July 2019

A partir del año 2000, se comenzó a definir el perfil del Museo de la Universidad de Costa Rica (museo+UCR); poco a poco se fue planificando, estructurando y apuntalando sus cimientos, desde el Centro de Investigación en Identidad y Cultura Latinoamericanas (CIICLA) y la Comisión Institucional de Colecciones, con el apoyo de las autoridades universitarias. El largo sueño universitario de contar con un museo era cada vez más preciso y cercano. Así, el 24 de junio del 2010, el Consejo Universitario aprobó la creación del Museo de la Universidad de Costa Rica. Por eso, en el 2015, se celebra el quinto aniversario de haber sido oficialmente fundado. La concreción de esto ha implicado un proceso continuo de reflexión y de trabajo con las diferentes colecciones de la Universidad. De esta manera, se ha ido conceptualizando el museo que se requiere; además, se ha ido evidenciado la necesidad de contar con un museo universitario. Por eso, se ha llegado al momento en que es preciso disponer de un espacio para ubicarlo. Ante esto, se ha esbozado un primer ejercicio museográfico y los alcances de una intervención al conjunto edilicio en que se ubica la Facultad de Ingeniería, es decir, edificio patrimonial destinado para el museo+UCR.
Sin miedo a verse en el espejo: El documental folk como preservador del patrimonio cultural inmaterial en Costa Rica
Authors: Chacón Martinez Lorna , Muñoz Knudsen Juan José
Published: July 2019

El presente artículo reflexiona acerca del documental en Costa Rica como una vía para el resguardo en imágenes del patrimonio cultural inmaterial del país. Plantea una propuesta de definición para este tipo de audiovisual, denominado Documental Folk, el cual refleja la identidad de una nación que ahora muestra sus múltiples rostros gracias a la narrativa digital y al papel de los prosumidores.
Editorial
Authors: Campos Ocampo Melvin
Published: July 2019

Editorial del nùmero, a cargo de Melvin Campos Ocampo.
Los petrograbados de Guayabo de Turrialba, Costa Rica: Un acercamiento a su significado
Authors: Herrera Amighetti Grace , Arias Quirós Ana Cecilia
Published: July 2019

El trabajo que presentamos forma parte de un conjunto de publicaciones que hemos conformado a partir de la investigación desarrollada con los petrograbados del sitio arqueológico Monumento Nacional Guayabo, Costa Rica. El sitio arqueológico refiere a un emplazamiento cuya complejidad se ubica, cronológicamente desde los 300 años antes de Cristo y hasta el 1550 d. C., momento histórico denominado en la arqueología de Costa Rica, tribal-cacical. Los diseños que hemos analizado representan, a partir de formas múltiples, elementos de la naturaleza, investidos de ese sentido social, propio de sociedades animistas con una participación directa delchamán o chamana en el diseño y elaboración de los petrograbados al conceptualizarlos como obras sacras, que comunicaban, educaban, daban identidad ycohesionaban al grupo social. La Arqueología y el Arte seunen en nuestros trabajos propiciando un a cercamiento a la forma, función y significado de estas obras en piedra, de esta historia socio-cultural.
El poró en la historia de la caficultura costarricense
Authors: Hilje Quirós Luko
Published: July 2019

Históricamente, la siembra del poró gigante o extranjero (Erythrina poeppigiana) como árbol de sombra en cafetales, ha sido una práctica agronómica común y de gran importancia en Costa Rica. Aunque se sabe que es de origen suramericano, no existe un documento específico que describa su origen geográfico exacto, así como por qué, cuándo y cómo fue introducido en Costa Rica. Por tanto, con base en varias fuentes, bastante dispersas, en este artículo se trata de contestar dichas preguntas, a la vez que sedescribe la manera en que la especie se diseminó y hasta desplazó a otras especies dominantes de leguminosas, como las guabas y los cuajiniquiles (Inga spp.), dependiendo de las diferentes regionescafetaleras del país. Asimismo, se identifica y reconoce a las personas e instituciones que hicieron posible este proceso.