bluuebunny/crossref_metadata_2025 huggingface dataset:
Формы реализации пропозиционального аргумента в русских предложениях с ментальными глаголами: „соблюдение”, „компрессия”, „расщепление”
Authors: Kiklewicz Aleksander
Published: November 2018

The subject of the article is the mental verbs (verbs of knowledge, understanding and thinking) of the modern Russian language, treated in terms of syntactic valence. The author examines the grammatical forms of the realization of propositional argument in sentences with mental verbs with the predicate-argument structure P (x, q). The forms of representation of propositional argument are divided into three types: observance, compression and splitting. The author shows that in this area we have to deal with an analog reflection of the propositional structure, or more or less a compression of proposition argument, or its dismemberment and doubling of its syntactic position. The author takes into account the regularity of the implementation of each grammatical form, quoting the relevant quantitative data.
Paremiologia na warsztacie leksykografa. W stronę słownika przyjaznego odbiorcy
Authors: Szutkowski Tomasz
Published: November 2018

The paper features a treatment of the basic postulates that are aimed at developing a proverb dictionary, which would, on the one hand, characterize the assembled material in an optimal and comprehensive way, and retain the status of a user-friendly dictionary, on the other hand. This “friendliness” is achieved through the simplification of formal description, the withdrawal of acronyms and references, and the reduction of redundant comments and explanations. The order of particular description elements is also of considerable importance in the process of developing a dictionary, which will, first and foremost, allow the user to easily acquire as broad a knowledge about proverbs as possible in an accessible and effective way.
Проблемы повышения эффективности преподавания иностран- ных языков и некоторые аспекты социальной лингводидактической теории
Authors: Siatkowski Stanisław
Published: November 2018

The article opens with a discussion of the main educational and organizational reasons, as well as other circumstances (for example, the lack of publicly entitled language policy in the country) for the relatively low effectiveness of recent teaching of foreign languages, in particular Russian language, in comparison to some highly developed countries in Western Europe. The author goes on to introduce the significant current substantive (scientific) issues of the new approach to a practically oriented theory of teaching foreign languages — social glottodidactics.
Antona Czechowa spojrzenie na bieg historii
Authors: Ksenicz Andrzej
Published: November 2018

Among the issues, themes and contributions which Anton Chekhov undertook in his works, one may also find the broadly-understood issue of an individual's place in the course of historical events. In this case, and others like it, this writer's opinion stands out among the works of other Russian writers. This is related to the fact that the author of The Steppe is convinced that the individual, and his conscious behaviour, contributes to the behaviour of a group and society. This is in contrast to the reasoning of most Russian writers of those times; however, it proves to be characteristic of Chekhov's thinking.
Motywy historiozoficzne w twórczości Fiodora Stiepuna
Authors: Ziomek Marcin
Published: November 2018

The aim of the article is to introduce the historiosophical views of Fyodor Stepun, one of the most prominent representatives of Russian emigration. In the 1920s, this thinker published a series of ten articles entitled Thoughts on Russia, which attempted to describe the Bolshevik revolution in the broadest possible sociocultural context. Thoughts on Russia are among the first texts interpreting the revolution in historiosophical terms.
The deployable telescope: a cutting-edge solution for high spatial and temporal resolved Earth observation
Authors: Dolkens Dennis , Kuiper Hans , Corbacho Victor Villalba
Published: November 2018

The increase of spatial and temporal resolution for Earth observation (EO) is the ultimate driver for science and societal applications. However, the state-of-the-art EO missions like DigitalGlobe’s Worldview-3, are very costly. Moreover, this system has a high mass of 2800 kg and limited swath width of about 15 km which limits the temporal resolution. In this article, we present the status of the deployable space telescope (DST) project, which has been running for 6 years now at the Delft University of Technology, as a cutting-edge solution to solve this issue. Deployable optics have the potential of revolutionising the field of high resolution EO. By splitting up the primary mirror (M1) of a telescope into deployable segments and placing the secondary mirror (M2) on a deployable boom, the launch volume of a telescope can be reduced by a factor of 4 or more, allowing for much lower launch costs. This allows for larger EO constellations, providing image data with a much better revisit time than existing solutions. The DST specification baseline, based on Wordview-3, aims to provide images with a ground resolution of 25 cm (panchromatic 450–650 nm) from an orbital altitude of 500 km. In this paper, the current status of the optical, thermo-mechanical, and active optics systems design are described. The concurrent design approach combined with a strict bottom-up and top-down compliant systems engineering approach show that the DST is a healthy system concept.
On the equidistribution of some Hodge loci
Authors: Tayou Salim
Published: November 2018

We prove the equidistribution of the Hodge locus for certain non-isotrivial, polarized variations of Hodge structure of weight 2 with

h

2
,
0

=
1

{h^{2,0}=1}

over complex, quasi-projective curves. Given some norm condition, we also give an asymptotic on the growth of the Hodge locus. In particular, this implies the equidistribution of elliptic fibrations in quasi-polarized, non-isotrivial families of K3 surfaces.
Certain Laplace transforms of convolution type integrals involving product of two special pFp functions
Authors: Milovanović Gradimir V. , Parmar Rakesh K. , Rathie Arjun K.
Published: November 2018

Recently the authors obtained several Laplace transforms of convolution type integrals involving Kummer’s function 1F1 [Appl. Anal. Discrete Math., 2018, 12(1), 257-272]. In this paper, the authors aim at presenting several new and interesting Laplace transforms of convolution type integrals involving product of two special generalized hypergeometric functions pFp by employing classical summation theorems for the series 2F1, 3F2, 4F3 and 5F4 available in the literature.
Schauen Sie, was Sie hören – Wie das Gehirn mit allen seinen Sinnen die Welt wahrnimmt
Authors: Noppeney Uta , Jones Samuel A. , Rohe Tim , Ferrari Ambra
Published: November 2018

Unsere Sinne werden fortwährend mit den unterschiedlichsten Signalen bombardiert. Um dieses Sinneschaos zu verstehen, muss das Gehirn Sinnesreize integrieren, wenn sie von einer Quelle kommen, aber separate verarbeiten, wenn sie von unterschiedlichen Quellen kommen. Somit beruht multisensorische Wahrnehmung entscheidend auf dem Erfassen der kausalen Struktur, die die Sinnesreize erzeugt hat. Verhaltensstudien legen nahe, dass das Gehirn zwischen Integration and Segregation wie von normativen Modellen der Bayesianischen kausalen Inferenz vorhergesagt abwägt. Neueste funktionelle Magnetresonanztomographie (fMRI) und Elektroenzephalographie (EEG) Studien zeigten, dass das Gehirn Bayesianische kausale Inferenz durchführt, indem es mehrere Wahrnehmungsschätzwerte dynamisch auf verschiedenen Ebenen der corticalen Hierarchie der Sinnesverarbeitung enkodiert. Erst an der Spitze der Hierarchie in anterioren parietalen Arealen formt das Gehirn Wahrnehmungsschätzwerte, die die Ungewissheit des Beobachters über die kausal Struktur der Umgebung berücksichtigt, wie von Modellen der Bayesianischen kausalen Inferenz vorhergesagt.
Vom lateralen Rand ins Zentrum des Kortex: Die Entwicklung der menschlichen Inselrinde
Authors: Meyer Gundela
Published: November 2018

Die menschliche Inselrinde ist ein Hauptknotenpunkt in einem neuronalen Netzwerk, welches aus dem eigenen Körper stammende Erregungen mit Einflüssen aus der Umwelt integriert und dabei die autonome, emotionelle und sozial-kognitive Homöostase des Körpers erhält. Die Insel ist in den letzten Jahren ins Zentrum der Aufmerksamkeit gerückt. Vergleichende anatomische Untersuchungen haben gezeigt, dass die Insel in vielen Spezies am lateralen Rand des Neokortex liegt. Wenig erforscht ist die vorgeburtliche Entwicklung der menschlichen Insel, die sich als frühestes Kortexareal entwickelt. Ursprung der Pyramidalzellen der Insel ist ein kleiner Abschnitt der proliferativen Ventrikulär/Subventrikulärzone an der kortikostriatalen Grenze (KSG). Von den hier liegenden Zellen der radialen Glia, die als Stammzellen dienen, entspringt ein dichtgewebtes Faszikel aus Gliafortsätzen, welches durch die Capsula externa läuft und als Migrationssubstrat für die Neuroblasten aus der KSG in die Insel dient. Um die 10/11 Schwangerschaftswoche biegen sich der Lateralventrikel und die ihm anliegende KSG C-förmig um, sodass sich die Insel nun zwischen einer dorsalen fronto-parietalen und einer ventralen, temporalen KSG entwickelt und von diesen mit absteigenden bzw. aufsteigenden Migrationsströmen von Neuroblasten entlang des radialen Gliafaszikels versorgt wird. Als Folge der Ventrikelrotation wird die menschliche Insel während der Ontogenese vom lateralen Rand des Kortex in dessen Mittelpunkt verlagert, was im Einklang mit ihren integrativen Funktionen innerhalb der Hirnaktivität steht.
From the lateral edge to the center of the cortex: The development of the human insula
Authors: Meyer Gundela
Published: November 2018

The human insula is a key node in a neuronal network which integrates interoceptive stimuli from the own body, and exteroceptive stimuli from the environment, and thus maintains the autonomic, emotional and socio-cognitive homeostasis of the body. In the last years, the insula has come into the focus of attention. Comparative anatomical studies showed that in many species the insula forms the lateral edge of the cortex. Very little is known about the prenatal development of the human insula, which is the first cortical region to mature. The origin of the pyramidal neurons for the insula is a small sector of the proliferating ventricular/subventricular zone at the cortico-striatal boundary (CSB). The CSB contains the radial glia cells, which are stem cells and give rise to a dense fascicle of radial glia processes. This fascicle traverses the external capsule and serves as a migration substrate for the neuroblasts on their way from the CSB into the insula. Around the 10/11th week of gestation, the lateral ventricle and its adjacent structures including the CSB bend in a C-shaped fashion. The insula now develops between a dorsal, fronto-parietal and a ventral, temporal CSB, which provide descending and ascending streams of neuroblasts, respectively, migrating along the radial glia fascicle. As a consequence of the ventricular rotation during ontogenesis, the human insula changes its initial position at the lateral edge of the cortex to its final central location, which reflects its integrative functions in brain activity.
On route with harbor seals – how their senses contribute to orientation, navigation and foraging
Authors: Hanke Frederike D. , Dehnhardt Guido
Published: November 2018

Summary: Seals and sea lions are well-oriented in their habitat, the coastal regions and oceans, and are, moreover, successful hunters. During their movements between haul-out places and foraging grounds as well as during foraging, the sensory systems of seals and sea lions provide useful information, although the animals, and thus their sensory systems, face considerable challenges in their habitat and due to their amphibious lifestyle. In this review, in the first chapter, we compiled and later (chapter 4) discuss the information on the senses of seals and sea lions in general and their specific adaptations to habitat and lifestyle in particular. We hereby focus on the senses of harbor seals. Harbor seals turned into a model organism regarding the sensory systems due to intensive sensory research of the last decades. In the second and third chapter, the sensory basics are put into the context of orientation, navigation, and foraging. This allows formulating new research questions, such as where and how the information from different senses is integrated.
Use of On-Demand Cloud Services to Model the Optimization of an Austenitization Furnace
Authors: Korambath Prakashan , Ganesh Hari S. , Wang Jianwu , Baldea Michael , Davis Jim
Published: November 2018

This article describes a smart manufacturing framework, comprising an on-demand, cloud-based deployment of a modeling application in a manufacturing operation. A specific use case, the optimization of the austenitization of steel parts, is presented. The framework uses a Kepler workflow as a cloud service to orchestrate and manage the data and computations required to implement a run-time model-based control and optimization approach on Amazon Web Services (AWS) resources. Austenitization is an energy intensive heat treating process commonly employed to harden and strengthen ferrous metals, such as steel. Pre-finished steel parts are heated to a specific temperature in a continuously operating industrial austenitization furnace without oxidizing the surface. The steel parts are then rapidly cooled or quenched in an oil bath. There is significant potential to optimize energy productivity by managing the energy usage needed to achieve the properties of the metal part instead of managing to operational process settings. Models of this process, which predict the furnace energy consumption and temperatures of parts as a function of time and position in the furnace and map temperatures to properties, have been previously developed; however, for operational use, the data and models need to be orchestrated for run-time operation, access to infrastructure, scalability, security, and support. A cloud-based approach is an alternative to the on-premise approach, in which an infrastructure for data, computational, and security needs to be built and maintained to support the application. A workflow service makes it possible to combine and sequence simulation and optimization software applications developed in several distinct MATLAB (The Mathworks Inc., Natick, MA) model configurations that are needed for various data-based calculations. The final output of the computation is the optimal operating condition of the furnace that minimizes the fuel consumption without violating the part target specifications. The workflow can be triggered on demand by an operator of the furnace or run at periodic intervals. All the computational resources required are instantiated and run at the start of the workflow and shutdown at the end of the workflow.
Domain Requirements and Genetic Interactions of the Mud1 Subunit of the Saccharomyces cerevisiae U1 snRNP
Authors: Agarwal Radhika , Schwer Beate , Shuman Stewart
Published: November 2018

Mud1 is an inessential 298-amino acid protein subunit of the Saccharomyces cerevisiae U1 snRNP. Mud1 consists of N-terminal and C-terminal RRM domains (RRM1 and RRM2) separated by a linker domain. Synthetic lethal interactions of mud1∆ with deletions of inessential spliceosome components Nam8, Mud2, and Msl1, or missense mutations in the branchpoint-binding protein Msl5 enabled us to dissect genetically the domain requirements for Mud1 function. We find that the biological activities of Mud1 can be complemented by co-expressing separately the RRM1 (aa 1-127) and linker-RRM2 (aa 128-298) modules. Whereas RRM1 and RRM2 (aa 197-298) per se are inactive in all tests of functional complementation, the linker-RRM2 by itself partially complements a subset of synthetic lethal mud1∆ interactions. Linker segment aa 155 to 196 contains a nuclear localization signal rich in basic amino acids that is necessary for RRM2 activity in mud1∆ complementation. Alanine scanning mutagenesis indicates that none of the individual RRM1 amino acid contacts to U1 snRNA in the cryo-EM model of the yeast U1 snRNP is necessary for mud1∆ complementation activity.
La política visual y editorial de la revista Diáspora(s) a través de sus cubiertas y manifiestos
Authors: Silva Guadalupe
Published: November 2018

AEl artículo analiza la revista Diáspora(s) (La Habana, 1997-2002) desde el punto de vista de su programa estético y político. Poniendo énfasis en el aspecto más concretamente material de la publicación (su forma de realización, distribución y circulación), propone una lectura del mensaje estético implícito en decisiones editoriales tales como el uso de los términos “proyecto”, “documentos” o “vanguardia”. El objetivo es mostrar, tanto a partir del análisis conceptual como del diseño y las cubiertas, la coherencia de la política visual y editorial de Diáspora(s) con su manifiesto programa “antilírico” y su fuerte discusión con la ideología del Estado. La puesta en contexto de Diáspora(s) resulta fundamental para comprender la potencia política de este proyecto en el marco de la Cuba postsoviética.
El telar de cintura, inmanencia itinerante de la memoria
Authors: Méndez González María Oliva
Published: November 2018

El testimonio histórico que se desprende de los textos coloniales, escritos por los hombres de la conquista, no registró el papel fundacional de las mujeres en la sociedad, sino que enunció, tácita y recíprocamente vinculados, los conceptos de nación y masculinidad. La institucionalización de la supremacía masculina constituye una de las razones por las cuales las mujeres figuran como el sector de la población más desposeído y violentado de la sociedad centroamericana actual. Como veremos en el siguiente análisis, el arte textil maya representa un lugar de la memoria colectiva que resiste los sistemas de dominación masculina.
Cuento
Authors: Escoto Ana
Published: November 2018

Ana Escoto (El Salvador, 1984) es economista y doctora en Estudios de Población, radicada en la ciudad de México, donde se dedica a la investigación y la docencia. No obstante, su alma se encamina a la narrativa breve y a la poesía. Perteneció en 2006-2007 al taller literario La Casa del Escritor, dirigido por Rafael Menjívar Ochoa. En narrativa ha publicado el libro de cuentos cortos “Menguantes y Otras Creaturas” (Dirección de Publicaciones e Impresos, 2008), así como ha contribuido con la antología “Memorias de la Casa – Narrativa” (Índole Editores, 2012), y con el proyecto de narrativa erótica “Cuerpos” (FyG Editores, 2015). También formó parte del proyecto bilingüe “Vanishing Points/Puntos de fuga” (Kalina, 2017) y ha participado en la antología internacional seleccionada por María Farazdel [Palitachi], “Voces de América Latina – Fictio – III” (Media Isla, 2016). Algunos de sus poemas han sido publicados en antologías en El Salvador como “Nuevas Voces Femeninas en El Salvador” (Universidad de El Salvador, 2009), “Memorias de la Casa – Poesía” (Índole Editores, 2010) y “Voces del Extremo” (2006) en Huelva, España, también está indizada en el “Segundo índice antológico de la poesía salvadoreña” (Vladimir Amaya, Índole Editores, 2014). En esta ocasión, la Revista Ístmica comparte dos cuentos de la autoría de Ana Escoto con nuestro público lector.
El outsourcing como estrategia de eficiencia: Tres estudios de caso en Costa Rica
Authors: Arce Soto Fabián , Chacón León Luz , España Chavarría Carolina
Published: November 2018

Esta investigación cualitativa, con la modalidad de estudio de caso, propicia lacomprensión teórica y práctica del outsourcing en la administración de recursoshumanos. Entre sus objetivos están el análisis conceptual y característicasdel objeto de estudio, identificar sus usos, riesgos y el proceso que conllevasu contratación en algunas empresas costarricenses. El abordaje temáticono pretende aprobar o desaprobar el uso del outsourcing como herramientade gestión empresarial, más bien, procura apoyar la comprensión del públicolector sobre este tema. A nivel práctico, la investigación intenta exponer eluso del outsourcing en un contexto real de negocios, evidenciando tres casos particulares en Costa Rica. Esto permitirá ver a través de la perspectiva de usuarios y usuarias cómo funciona el outsourcing, qué actividades son las que han subcontratado y cuáles se prefieren realizar con personal de planta. Entre los hallazgos más significativos del outsourcing están: a) Su ejecución en función de metas específicas de la organización y b) Su implementación bajo la responsabilidad de un equipo integrado por personas internas y externas a la organización que aseguren el buen manejo del proceso y un destacado involucramiento de la alta gerencia y las gerencias de cada una de las áreas relacionadas con el proceso de subcontratación.
Erectile Dysfunction and Ischaemic Heart Disease
Authors: Ibrahim Abdalla ,   Cardiology Department, University Hospital Limerick, Limerick, Ireland, Ali Mohamed ,   Cardiology Department, St James’s Hospital, Dublin, Ireland, Kiernan Thomas J ,   Cardiology Department, University Hospital Limerick, Limerick, Ireland, Stack Austin G ,   Division of Nephrology, University Hospital Limerick, Limerick, Ireland
Published: November 2018

Erectile dysfunction (ED) is a common disorder that affects the quality of life of many patients. It is prevalent in more than half of males aged over 60 years. Increasing evidence suggests that ED is predominantly a vascular disorder. Endothelial dysfunction seems to be the common pathological process causing ED. Many common risk factors for atherosclerosis such as diabetes, hypertension, smoking, obesity and hyperlipidaemia are prevalent in patients with ED and so management of these common cardiovascular risk factors can potentially prevent ED. Phosphodiesterase type 5 inhibitors provide short-term change of haemodynamic factors to help initiate and maintain penile erection. They have been shown to be an effective and safe treatment strategy for ED in patients with heart disease, including those with ischaemic heart disease and hypertension.
Agronomic evaluation and clonal selection of ginger genotypes (Zingiber officinale Roseoe) in Brazil
Authors: Zambrano Blanco Eleonora , Baldin Pinheiro José
Published: November 2018

The analysis of the genetic diversity of ginger based on agronomic traits is essential to know its performance and to design breeding programs. In this study, we analyzed the phenotypic variability of 61 accessions of the ginger germplasm collection of the "Luiz de Queiroz" College of Agriculture at the University of Sao Paulo (ESALQ/USP) in a complete randomized block design with four replications. An analysis of variance test was performed and genetic parameters such as heritability, genetic variance, environmental variance, genetic-environmental variation ratio (CVg/CVe) and genetic correlations were estimated. There were highly significant differences (P≤0.01) among the accessions for all the agronomic traits analyzed. The CVg/CVe ratio (>1), along with the high heritability (>80%), showed a significant contribution of genetic factors on the phenotypic expression of plant height, rhizome thickness and yield traits, favoring the clonal selection of genotypes. Accessions Gen-29, Gen-29, Gen-32, Gen-36, Gen-37, Gen-40, Gen-41, Gen-42, Gen-50 were selected due to the best agronomic performance when compared to the rest of the germplasm. The results obtained may be useful in future breeding programs in Brazil.
Fitting of photosynthetic response curves to photosynthetically active radiation in oil palm
Authors: Rivera-Mendes Yurany Dayanna , Romero Hernán Mauricio
Published: November 2018

Light saturation curves represent the response of the net photosynthetic rate to the photosynthetically active radiation. These curves were obtained from individual leaves of oil palm genotypes (Elaeis guineensis, E. oleifera and the O.G interspecific hybrid) without any type of biotic or abiotic stress, fitting three nonlinear models: the rectangular hyperbolic model (Michaelis-Menten), the non-rectangular hyperbolic model (Prioul and Chartier) and the exponential model (Mitscherlich). The research was conducted at Barrancabermeja (Santander, Colombia) with the aim to compare the adaptations of these models and to identify the most suitable model for the crop. The rectangular hyperbolic model was qualitatively and quantitatively the most appropriate to describe the oil palm response under different conditions, in terms of the coefficient of determination (R2 a), the mean squared error (MSE) and the standard error (SE); therefore, using this model, the photosynthetic parameters showed higher and more realistic correlation (r) with the measured values. The non-rectangular hyperbolic model was the least appropriate model to estimate the maximum photosynthesis, dark respiration, saturation points, light compensation and photosynthetic efficiency. Thus, the rectangular hyperbolic model is the fastest, simplest and most appropriate option to access the light curve information in oil palms and can be incorporated into the gas exchange and growth models into the whole palm production system.
NIVEL DE DESEMPEÑO AUTOPERCIBIDO POR FUTURAS EDUCADORAS DE PÁRVULOS SOBRE EL USO PEDAGÓGICO DE TIC- Level of self-perceived performance by future nursery educators on the pedagogical use of ITC
Authors: Flores-Lueg Carolina , Mena-Bastías Carmen , Arteaga-González Patricia , Navarrete-Troncoso Lucía , Gajardo-Rodríguez Ana
Published: November 2018

En este trabajo se presentan los resultados preliminares de un estudio llevado a cabo en una institución de educación superior chilena, cuyo propósito estuvo orientado a establecer la autovaloración que poseen las estudiantes de 2º y 3º año de la carrera de Pedagogía en Educación Parvularia sobre el nivel de logro de su competencia digital, desde una dimensión pedagógica del uso de TIC. La metodología utilizada fue cuantitativa, con un diseño descriptivo. Participaron un total de 69 estudiantes de segundo y tercer año de formación, a quienes se les aplicó la Escala de autoevaluación de competencias digitales para estudiantes de Pedagogía, en su dimensión pedagógica. Los resultados evidencian que las estudiantes en general poseen una buena valoración sobre su desempeño en el uso pedagógico de TIC, salvo en lo que respecta a la práctica evaluativa apoyada por TIC, pero dicha valoración se enmarca dentro de un modelo tradicional de enseñanza.
Eribulin Mesylate as Third or Subsequent Line Chemotherapy for Elderly Patients with Locally Recurrent or Metastatic Breast Cancer: A Multicentric Observational Study of GIOGer (Italian Group of Geriatric Oncology)-ERIBE
Authors: Leo Silvana , Arnoldi Ermenegildo , Repetto Lazzaro , Coccorullo Zaira , Cinieri Saverio , Fedele Palma , Cazzaniga Marina , Lorusso Vito , Latorre Agnese , Campanella Giovanna , Ciccarese Mariangela , Accettura Caterina , Pisconti Salvatore , Rinaldi Antonio , Brunetti Cosimo , Raffaele Mimma , Coltelli Luigi , Spazzapan Salvatore , Fratino Lucia , Petrucelli Luciana , Biganzoli Laura
Published: November 2018

Background

Metastatic breast cancer (MBC) is highly prevalent in middle-aged or elderly patients. Eribulin is a nontaxane microtubule inhibitor, approved for the treatment of pretreated MBC. This multicentric study (sponsored by GIOGer, Italian Group for Geriatric Oncology) was designed to assess the efficacy and tolerability of eribulin, according to parameters usually used in geriatric oncology.

Subjects, Materials, and Methods

An observational study was conducted on 50 consecutive elderly patients with MBC. The primary endpoint was to evaluate the change in items score of comprehensive geriatric assessment (CGA) and health-related quality of life (HRQL). Italian versions of the CGA and HRQL questionnaires were administered at baseline, before the third and fifth cycles, and then every three cycles until treatment discontinuation. Secondary endpoints were efficacy and safety.

Results

Overall, both EQ-5D scores and EQ-5D-3 L visual analogic scale did not significantly change from baseline; the percentage of subjects without problems doing usual activities tended to decrease during treatment (p for linear trend .018), and the percentage of patients with minor problems performing usual activities tended to increase (p for linear trend.012). Among CGA items, Instrumental Activities of Daily Living tended to decrease during treatment and Geriatric Depression Scale tended to increase. After 12 months follow-up, 24 patients (out of 47) showed clinical benefits; median progression-free survival was 4.49 months (2.10–10.33) and median OS was 7.31 months (3.70–14.03). The treatment was associated with mild toxicity.

Conclusion

Eribulin treatment preserved quality of life and geriatric parameters included in the CGA, except for instrumental functioning and geriatric depression, in elderly patients with MBC.
Capecitabine and Temozolomide as a Promising Therapy for Advanced Thymic Atypical Carcinoid
Authors: Wang Xin , Li Yuanliang , Duan Jianghui , Chen Yingying , Yuan Bing , Qi Zhirong , Tan Huangying
Published: November 2018

Background

Thymic atypical carcinoid (TAC) is a rare thymic neuroendocrine tumor that originates in the neuroendocrine system and lacks a standardized treatment. The combination of capecitabine (CAP) and temozolomide (TEM) is associated with an extremely high and long-lasting response rate in patients with metastatic pancreatic neuroendocrine tumors. However, there is little evidence showing that the CAPTEM regimen is effective for TAC. For patients with unresectable or metastatic atypical carcinoid of the thymus, few treatment options are available, and the treatment efficacy is not satisfactory. To explore the efficacy and safety of the CAPTEM regimen against TAC, we conducted a retrospective review.

Patients and Methods

A total of nine patients with advanced atypical carcinoid of the thymus in the China-Japan Friendship Hospital were treated with capecitabine (750 mg/m2 twice daily, days 1–14) and temozolomide (200 mg/m2 once daily, days 10–14) every 28 days between 2014 and 2018. The disease control rate (DCR), progression-free survival (PFS), and adverse effects after treatment were analyzed. The DCR was calculated by RECIST version 1.1. Progression-free survival was calculated by the Kaplan-Meier survival method.

Results

A total of nine patients (six male and three female) were included. The median age at CAPTEM initiation was 50 years (range, 26–58). The median number of CAPTEM cycles was 8 (range, 3–23). The DCR was 89% (8/9), with eight patients achieving stable disease. Only one patient (11%) showed progressive disease. The median PFS was 8 months. Because we applied vitamin B6 and ondansetron before administering the drugs, the side effects of this regimen were very small. Adverse reactions were all below grade 3 and included myelosuppression and digestive tract reaction.

Conclusion

Our results suggest that the CAPTEM regimen may be effective and well tolerated for the treatment of TAC. More evidence is needed to validate the effectiveness of this regimen.
Protecting Patient Privacy in Narratives: The Lifespan-Brown Checklist for Appropriate Use of Patient Narratives
Authors: Rafelson William , Bruno Jane , Dizon Don S.
Published: November 2018

How can we support narratives written by clinicians in a way that promotes reflection without breaching the confidentiality inherent within the patient-provider relationship? This narrative provides some guidance, with the Brown-Lifespan Checklist for Narratives.
Estimating and communicating the risk of neglecting maintenance
Authors: Adey Bryan T , Martani Claudio , Papathanasiou Natalia , Burkhalter Marcel
Published: November 2018

The difficulties of engineers and managers agreeing on how to invest in infrastructure maintenance stem from a basic inability to communicate with each other. This leads to the suboptimal management of infrastructure. Luckily, this situation can be remedied by engineers learning how to communicate their concerns in a way that managers can understand, so that they can clearly see whether a proposed action needs to be taken or can be deferred. This paper shows, with the help of a realistic example, in terms of infrastructure, methodology and techniques, how this can be done. The proposed approach, although upon reading is perhaps intuitive, is starkly absent in the literature in the field of infrastructure asset management. In the proposed approach, it is demonstrated how to improve the traditional approaches used by engineers to communicate to managers through (a) the quantification of the level of service as seen by mangers, (b) the modelling of how infrastructure might not provide the required level of service and (c) the way of showing how intervention programmes can affect the provision of service, both now and in the future.
Educação permanente em saúde e equipes do NASF: revisão de literatura
Authors: Gomes de Matos Bárbara , Fogaça Rosa Ribeiro Sandra , Cris Pires Sales Pina Ekelis
Published: November 2018

Esta pesquisa teve como objetivo identificar como os profissionais dos Núcleos de Apoio à Saúde da Família (NASF) utilizam a Educação Permanente em Saúde em seu cotidiano com as equipes de Saúde da Família, através de uma revisão de literatura. Realizou-se a análise de seis artigos, os quais foram escolhidos por meio de uma pesquisa na plataforma Lilacs em Março de 2017. Diante dos resultados obtidos, foi possível perceber a grande dificuldade dos profissionais em lidarem com o trabalho pensado coletivamente e para o coletivo, abrangendo suas demandas e mudanças cotidianas. Ainda há nas equipes incertezas e falta de formação sobre a prática no NASF, acarretando falta de planejamento e direcionamento para o trabalho. Também, foi identificado como a saúde pública continua marcada pela tradição fragmentada, pautada em especialistas e atendimentos individuais, o que se distancia consideravelmente do esperado para a atenção primária.
Üç Boyutlu (3D) Laparoskopik Kolesistektomi; Isparta Şehir Hastanesi’ndeki Başlangıç Deneyimimiz
Authors: ÇELİK Girayhan
Published: November 2018

Laparoskopik cerrahi; cerrahi travmayı, hastanede kalış süresini, ameliyat sonrası ağrıyı azaltması gibi avantajlara sahiptir. Laparoskopik cerrahide gelişen teknolojiyle birlikte meydana gelen yenilikler laparoskopik prosedürlerin güvenliğini ve uygulanabilirliğini artırmıştır. İki boyutlu (2D) laparoskopinin kısıtlılıkları üç boyutlu (3D) laparoskopik sistemlerin gelişmesiyle azalmıştır. Geçmişte yapılan bazı çalışmalarda 3D sistemlerin çok fazla avantaj sağlamadığı yönünde çıkan sonuçlar o dönemdeki ve günümüzdeki 3D sistemler arasında ciddi teknolojik farklılıklar nedeniyle son dönemlerde yapılan çalışmaların sonuçlarıyla tam olarak karşılaştırılmamalıdır. 3D ve 2D laparoskopiyi karşılaştırarak yapılan araştırmalar komplike işlemlerde 3D sistemlerin işlem süresini ve hata oranını azalttığı gösterilmiştir. Çalışmamızdaki vakalarda 3D görüntünün derinlik hissinin verdiği anatomiye hakimiyet ve geniş çalışma alanı ameliyatın tüm aşamalarında daha güvenli ve daha kararlı hareket imkanı sağladı. Maliyete bağlı nedenlerden dolayı 3D sistemlerin yaygınlaşamaması bu konuda yeterli çalışma yapılamasına engel olmaktadır. 3D sistemlerin etkinliğinin daha iyi değerlendirilmesi için uzun süreli ve geniş vaka sayılı çalışmalara ihtiyaç vardır.
Beceri Öğrenim Rehberi ve Değerlendirme Rehberi Hazırlama: HPV-DNA Numune Alma Örneği
Authors: BAŞER Aysel , DEMİRAL YILMAZ Nilufer , ŞAHİN Hatice
Published: November 2018

Amaç:

Kadınlarda serviks
kanseri önemli bir sağlık sorunudur. Serviks kanseri tarama yöntemleri invazif
kanser insidansını ve mortalitesini azalttığı düşünülen az sayıdaki tarama
yönteminden biridir. Sağlık Bakanlığı son dört yıldır 30-65 yaş kadınlarda HPV
numune alma veya pap-smear ile tarama başlatmıştır.

Ulusal Çekirdek Eğitim
Programı 2014 (UÇEP 2014) her tıp fakültesi mezunun nitelikli bir hekim olması
için sahip olması gereken temel gerekliliklere/yeterliklere yönelik olan ve tıp
eğitimi süresince her bir öğrencinin alması gereken asgari eğitimin içeriğini
tanımlamaktadır (1). UÇEP 2014’te koruyucu sağlık hizmetleri başlıkları incelendiğinde
serviks kanseri taraması da yer almaktadır (1). Mezuniyet öncesi dönemde tıp
öğrencileri pap-smear tarama ile ilgili beceriyi öğrenmelerine rağmen HPV ile
ilgili numune alma konusunda herhangi bir beceri eğitimi almamakta ve
değerlendirme yapılmamaktadır.

 Yöntem:

Çalışmada Sağlık
Bakanlığı’nın serviks kanseri tarama programında geliştirdiği HPV DNA numune
alma şeması ve pap-smear alma becerisi eğitim kılavuzu temel alınmıştır.
UÇEP’te yer alan ‘hasta ile iletişim, hastayı hazırlama, sterilizasyona uyum,
HPV DNA ve pap-smear numune alma, atık yönetimi ve numune saklanması, vajinal
muayene’ başlıkları göz önünde bulundurularak 40 maddeden taslak eğitim
rehberi oluşturulmuştur (1). Lawshe tekniği kullanılarak uzman görüşleri
doğrultusunda farklı meslek gruplarında (aile hekimliği uzmanı, diş hekimliği,
kanser tarama merkezi hekimi, ebe ve hemşire) pilot çalışması yapılarak nihai
eğitim rehberi oluşturulmuştur. Mesleksel beceri eğitim rehberi oluşturulduktan
sonra uzman görüşüne başvurularak değerlendirme rehberinde hasta ile iletişim,
hastayı hazırlama, sterilizasyona uyum, numune alma, atık yönetimi ve numune
saklanması başlıklarının bu becerinin sınanmasında kullanılması öngörülmüştür.

Bulgular:

Geliştirilen HPV DNA
numune alma beceri eğitim rehberi Lawshe tekniği kullanılarak KGO %100 ile uzman
görüşleri doğrultusunda 33 maddeden oluşturulmuştur. Eğitim rehberinin
ölçeklemesinde  ‘geliştirilmesi gerekir,
henüz olgunlaşmamış, yeterli, iyi seviyede, ustalaşmış’ basamakları
kullanılmıştır. HPV DNA numune alma becerisini değerlendirme amacıyla 20
maddeden oluşan ve 5’li Likert ölçeği ile puanlanan bir değerlendirme rehberi
geliştirilmiştir.

Sonuç:

Ülkemizde tıp
fakültesinden mezun olan hekim, uzmanlık eğitimine başlamadığı sürece çoğunlukla
Sağlık Bakanlığı’na bağlı birinci basamak sağlık hizmetlerinde çalışmaktadır.
Bu nedenle çalışma koşulları ile uyumlu ve UÇEP 2014’te tanımlanan beceri
başlıklarının tıp fakültelerinde yeterliliği sağlayacak düzeyde öğretilmesi ve
geliştirilen değerlendirme rehberi eşliğinde sınanması esastır. Böylece beceri
uygulamaları konusunda yeterli hekimler çalışma hayatında da özgüvenli,
başarılı ve diğer sağlık personellerine de öncü olacaktır.
Oral feeding of bacteria to house flies for microbe fate and gene expression analysis v1
Authors: Nayduch Dana , Meier Hayley , Mccoy Christine
Published: November 2018

Objective: To feed individual house flies a specific amount of bacteria in order todetermine bacteria “fate” (persistence, via enumeration; spatiotemporal location, viamicroscopy) and house fly immune response (whole fly or tissue-specific, viadownstream mRNA or protein expression analyses).
Human Heart Nuclei Isolation for DroNc-seq v1
Authors: Lozano Stephanie
Published: November 2018

Recent advances in single cell mRNA sequencing technology such as Drop-seq (Cell, 2015) have allowed the investigation of cellular composition and processes within complex tissues. Although some fresh tissue samples are available for prospective studies, there is an abundance of archived clinical samples readily available in biobanks to investigate different biological processes. However, archived tissues are not easily amenable to tissue digestion, yielding cells with compromised integrity. An alternate method to single-cell sequencing called DroNc-seq (Nature Methods, 2017) employs the use of single nuclei. DroNc-seq takes advantage of the higher structural integrity of the nuclear membrane as compared to the cellular membrane. This permits exploration of tissues for which a viable single-cell suspension cannot be obtained, such as cardiac tissue. With growing interest in cataloguing cardiac transcriptomic data for the Human Cell Atlas Project, the need for optimized nuclei isolation protocols proves critical. Here, we develop a method for obtaining single-nucleus suspensions from snap-frozen human heart tissue for use in DroNc-seq, expanding the variety of samples from which we can obtain transcriptomic data.
Chromosome-scale genome assembly of kiwifruit Actinidia eriantha with single-molecule sequencing and chromatin interaction mapping v1
Authors: Sun Xuepeng , Liu Yongsheng , Fei Zhangjun
Published: November 2018

This protocol includes a computational pipeline used in assembly and annotation of Kiwifruit Actinidia eriantha genome.
Chromosome-scale genome assembly of kiwifruit Actinidia eriantha with single-molecule sequencing and chromatin interaction mapping v2
Authors: Tang Wei , Sun Xuepeng , Yue Junyang , Tang Xiaofeng , Jiao Chen , Yang Ying , Niu Xiangli , Miao Min , Zhang Danfeng , Huang Shenxiong , Shi Wei , Li Mingzhang , Fang Congbing , Fei Zhangjun , Liu Yongsheng
Published: November 2018

This protocol includes a computational pipeline used in assembly and annotation of Kiwifruit Actinidia eriantha genome.
Bounce PCR v2
Authors: Mugford Sam , Hogenhout Saskia
Published: November 2018

Bounce PCR: optimisation free PCR for synthetic biology cloning applications. Synthetic biology projects require the cloning of multiple DNA components, and increasingly this is done though in-vitro gene synthesis. This remains an expensive alternative to traditional cloning by PCR. However, PCR often requires time-consuming optimisation. Bounce PCR is a largely optimisation-free PCR method suitable for the rapid cloning of multiple targets. Bounce PCR is a modified version of Touchdown PCR that takes advantage of primer-extension sequences -commonly used in molecular cloning – to successfully amplify most DNA fragments without time consuming optimisation. Touchdown (and related methods) employ a sequential lowering of the annealing temperature over successive cycles to minimise non-specific primer-binding during the early amplification cycles, but maximise amplification efficiency in later cycles when the target amplicon is more abundant (Don et al. 1991; Rowther et al. 2012). However, the lower annealing temperature in later cycles may still allow for non-specific amplification. Bounce PCR takes advantage of the increased primer melting temperature caused by the addition to the template of primer-extension sequences (for example: restriction enzyme recognition sites, Gateway recombination sites, or vector overlaps for Gibson cloning) to maintain the specificity in later cycles- without sacrificing efficiency- by increasing the annealing temperature again after an initial round of touchdown. Don, R. H., Cox, P. T., Wainwright, B. J., Baker, K., & Mattick, J. S. (1991). 'Touchdown' PCR to circumvent spurious priming during gene amplification. Nucleic acids research, 19(14), 4008. Rowther, F. B., Kardooni, H., & Warr, T. (2012). TOUCH-UP gradient amplification method. Journal of biomolecular techniques : JBT, 23(1), 1-3.
Copy of Oral feeding of bacteria to house flies for microbe fate and gene expression analysis v1
Authors: Nayduch Dana , Meier Hayley , Mccoy Christine
Published: November 2018

Objective: To feed individual house flies a specific amount of bacteria in order todetermine bacteria “fate” (persistence, via enumeration; spatiotemporal location, viamicroscopy) and house fly immune response (whole fly or tissue-specific, via downstream mRNA or protein expression analyses)
Children’s Involvement in Supplementary Education: Monitoring and Value of Education on the Part of Parents
Authors: Bochaver A.A. , Verbilovich O.E. , Pavlenko K.V. , Polivanova K.N. , Sivak E.V.
Published: November 2018

The paper explores parental attitudes towards additional education basing on the materials of 20 interviews with parents of schoolchildren. We analyse the ideas about the value and objectives of additional education among parents in the context of three types of children’s involvement in additional education — high, flickering and low. We then discuss parental practices of control over children's education and of maintaining children's motivation and compare their views on the problems solved by different areas of activities (foreign languages, sports and dance, visual arts, revising the curriculum with the help of tutors, computer knowledge).Also, we focus on the strategies of "maximal" and "optimal" filling of out-of-school educational space that is common among parents of children with high involvement in additional education. The paper concludes with reflections on the significance of the family in the organization of the child’s educational space since the parents and other members of the family are the primary initiators, organizers, actors responsible for the child’s educational space.
Evaluation of the Semantic Dynamics of Educational Space of University in the Process of Nurturing Critical Thinking in Students of Liberal Arts and Sciences Programme
Authors: Polyanina O.I. , Baleva M.V. , Shevkova E.V.
Published: November 2018

The study is devoted to the analysis of the connotative dynamics of the concepts describing the educational space of university in students of Liberal Arts and Sciences degree programme who took a course in “Thinking and Writing”. The hypothesis tested was that there would be a dynamic trend towards greater differentiation and individualization of concepts "student", "learning" and "training group" in the experimental group as compared to the control sample. The participants (152 students, including 126 females and 26 males aged from 17 to 23, M = 17.91, SD = 0.79) evaluated these concepts using the Semantic Differential Scale before and after the course. It was found (p <0.10 ÷ 0.05) that in the experimental sample the connotations for "student" showed an increase in imagery and subjective evaluation component, and the concept "learning" was assessed as less hostile and more diverse. In turn, the connotative dynamics of the meanings for "training group" was similar to that of the control group. The obtained results are of primary interest in the context of shaping the students’ learning motivation and can be employed in comparative studies of the effects produced by conceptually different educational programs.
Psychosocial Development in Schoolchildren: Creating and Testing the Monitoring System
Authors: Ilyin V.A. , Ilyichyova I.V. , Levanova E.A. , Mikhailova E.A. , Pushkareva T.V.
Published: November 2018

In this paper we argue that creating and implementing a monitoring system for psychosocial development of schoolchildren is reasonable as it is one of the most effective and easily applied means of addressing a number of significant tasks, both psychological/pedagogical and organizational/administrative. In the context of testing the general hypothesis that the introduction of the monitoring system will promote individually oriented approach to learning without radical transformation of the existing secondary education system we developed and verified a set of techniques to be used in the monitoring, including the following: differential of psychosocial development, technique for defining group value orientations, and a social psychological modification of G. Kelly’s repertory grid. The paper presents outcomes of a study that aimed to prove the heuristic character of the chosen theoretical and methodological approach; it was carried out on a sample of children of 6th—10th classes of the Moscow school #1409.It is shown that monitoring of psychosocial development of schoolchildren helps to reveal educational and developmental difficulties and develop effective means of psychological and pedagogical intervention taking into account the specifics of a particular educational institution.