bluuebunny/crossref_metadata_2025 huggingface dataset:
Late-Term Complications of COVID-19: Retropharyngeal Infection and Myocarditis in a 26-Year-Old Patient
Authors: Mohammad Yousef Mohammad Yousef , Abdelazeem Basel , Kalantary Atefeh , Pratiti Rebecca
Published: October 2021

Deep neck space infection and viral myocarditis related to coronavirus disease 2019 (COVID-19) have both been described in the medical literature. However, there are only three reported cases of retropharyngeal infection as a presenting pathology in the setting of COVID-19. A 26-year-old woman presented to the emergency room with fever and neck swelling and pain 1 month after COVID-19 infection. A computed tomography scan of the neck demonstrated tonsillitis with retropharyngeal infection. She was also found to have heart failure with an ejection fraction (EF) of <20% due to acute myocarditis. Her infection resolved and the EF improved to 40% prior to discharge. Our case is the first to describe retropharyngeal infection as a late complication in an adult with a history of COVID-19 several weeks previously. It also presented a clinical challenge in terms of tailoring goal-directed medical therapy to manage severe left ventricular dysfunction caused by myocarditis.
Comparison of balance ability and physical fitness according to the growth period in taekwondo players
Authors: Choi Dong-Sung , Jung Eun-Na , Park Min-Hyuk
Published: October 2021

The purpose of this study was to investigate and evaluate balance ability, isokinetic moments, and physical fitness according to the growth period from middle school to university in male taekwondo players. Thirtyfive taekwondo players (middle school, n= 11; high school, n= 15; university, n= 9) participated in this study. The anteriorposterior and medial-lateral CoP displacement at balance ability was better in university players than in high school and middle school players. The isokinetic knee joint muscle strength of the right extension and flexion % body weight (BW) at 60°/s was higher in university players than in high school players. The average power of right flexion BW at 180°/sec was higher in middle school players than in high school players. Back strength was higher in university players than in middle and high school players. The repeated jump was higher in high school players than in middle school players. The standing broad jump was higher in university players than in middle school players. The side-step was higher in university players than in high school players. The average power and total energy of anaerobic power were higher in university and high school players than in middle school players. The peak drop in anaerobic power was higher in middle school players than in high school players. Based on the results of the present study, the growth period should be considered when applying training such as balance, isokinetic moments, and physical fitness to male taekwondo players.
Bilateral counter movement jump, squat, and drop jump performances in deaf and normal-hearing volleyball players: a comparative study
Authors: Makaracı Yücel , Özer Ömer , Soslu Recep , Uysal Abdullah
Published: October 2021

Since deaf athletes do not have any physical deficiencies, it is known that they can easily participate in sports competitions if their communication problems are resolved. This study aimed to compare the performances of olympic deaf and elite normal-hearing volleyball players in different jumping test protocols. A total of 26 male volleyball players participated in the study, comprised of 12 olympic level deaf and 14 elite level normal-hearing. Following anthropometric measurements, athletes performed bilateral counter movement, squat and drop jump tests on a force plate. Each test was performed 3 times with maximal effort separated by 45 seconds of passive recovery and the mean of the three trials was selected for analysis. Independent Samples t-test was used to compare the differences in mean values of jumping test parameters between the groups. Normal-hearing athletes are observed to have significantly better scores than deaf athletes in all test protocols. Considering that the number of studies on athletic performance in deaf athletes is limited, it can be said that our study will contribute to researchers and coaches in respect of detecting a key ability in volleyball, such as jumping, in different jump protocols.
The use of elastic band exercise as a physical therapy intervention for improving shoulder function in older adults: a scoping review
Authors: Kim Minjoon , Kuruma Hironobu , Thawisuk Chirathip
Published: October 2021

Many older adults experience a decline in shoulder function due to aging. This decline leads to limitations in daily activities and a lower quality of life. The incorporation of physical therapy interventions through elastic band exercises has demonstrated improved overall physical faculties among older adults. However, there is limited literature regarding the effect of these interventions on shoulder function in older adults. This scoping review summarized the current literature regarding elastic band exercises targeting shoulder function in older adults. A systematic literature search was performed using the Scopus and PubMed databases. An additional manual search was conducted using the PEDro (Physiotherapy Evidence Database). Articles were included if they were published in a peer-reviewed journal in 2017–2021. After assessing eligibility, five randomized controlled trials articles were included in the analysis. We discovered that two types of elastic interventions were applied to older adults: namely, the TheraBand and tube bands. We observed heterogeneity in participant characteristics among the studies (healthy older adults, older adults with chronic obstructive pulmonary disease, and older adults with sarcopenic obesity). The duration of the exercise intervention ranged from 3 to 36 sessions. Only one study measured shoulder function as the primary outcome. Our findings suggest that elastic band exercises have been applied to older adults in various conditions and tended to be effective; however, evidence on this topic is insufficient.
Sophisticated regulation of micturition: review of basic neurourology
Authors: Lee Chung Lyul , Lee Jaegeun , Park Jong Mok , Na Hyun Seok , Shin Ju Hyun , Na Yong Gil , Kim Khae Hawn
Published: October 2021

The neurological regulation of the lower urinary tract can be viewed separately from the perspective of sensory neurons and motor neurons. First, in the receptors of the bladder and urethra of sensory nerves, sensations are transmitted through the periaqueductal gray matter of the midbrain to the cerebral cortex, and the cerebrum goes through the process of decision-making. Motor neurons are divided into upper motor neurons (UMNs) and lower motor neurons (LMNs). UMNs coordinate storage and micturition in the brain stem so that synergic voiding can occur. LMNs facilitate muscle contractions in the spinal cord. The muscles involved in urinary storage and micturition are innervated by the somatic branches of sympathetic, parasympathetic, and peripheral nerves. Sympathetic nerves are responsible for contractions of urethral smooth muscles, while parasympathetic nerves originate from S2–S4 and are in charge of contractions of the bladder muscle. Somatic nerves originate from the motor neurons in Onuf’s nucleus, which is a specific part of somatic nerves. In this review, we will investigate the structures of the nervous systems related to the lower urinary tract and the regulatory system of innervation for the urinary storage and micturition and discuss the clinical significance and future prospects of neurourological research.
Study on the Characteristic Components of Distinguishing Dalbergia cochinchinensis from the Other Three Similar Dalbergia Species
Authors: Zhang Fang-Da , Wang Ji-Lei , Guo Li-jin , Huang An-Min , Wang Wenna
Published: October 2021

Dalbergia cochinchinensis can be distinguished from Dalbergia retusa, Dalbergia bariensis, and Dalbergia oliveri quickly using infrared spectrum characteristic peaks as shown in a previous study. To investigate the components corresponding to the infrared characteristic peaks of Dalbergia cochinchinensis, petroleum ether, ethyl acetate, and butyl alcohol were sequentially used to extract the dispersion liquid of D. cochinchinensis. The petroleum ether extracts were further fractionated by column chromatography, using Fourier-transform infrared spectroscopy (FTIR) to track the characteristic components during separation. FTIR spectra of petroleum ether extractives indicated the presence of aromatic ketones and olefin compounds. The gas chromatography–mass spectrometry research showed some main components and gave possible structure. Furthermore, their detailed structures were characterized thorough a nuclear magnetic resonance approach, and then two possible components (3,5-dihydroxy-7-methoxy-2-phenylchroman-4-one and 3,5,7-trihydroxy-2-phenylchroman-4-one) were identified.
Codeswitching auf einem hochdiversen urbanen Wochenmarkt: Kommerz, Kommunikation und Identität
Authors: Yüksel Serkan , Duman İrem
Published: October 2021

Today's European cities exhibit a great cultural and linguistic diversity. Highly diverse urban areas bring together people from different sociolinguistic backgrounds and thus facilitate intense language contact, with speakers accessing diverse linguistic resources that they creatively use and mix (cf. e. g. Wiese 2020; Otsuji/Pennycook 2010; Pennycook/Otsuji 2015). Such linguistic practices include code-switching.

In previous research on code-switching the focus was on relatively homogeneous settings, mostly bilingual communities (cf. Poplack 2015; Torres Cacoullos/Travis 2015; Bullock/ Toribio 2009). As a part of a larger project, we collected spontaneous speech data through audio and video recordings from a highly diverse street market in Berlin-Neukölln that is popular among locals and tourists, the “Maybachufer-Markt”.

The analysis of our data reveals new insights with respect to sociolinguistic motivations underlying code-switching. In light of commercial intentions, vendors try to switch to a language according to how they construct the customers’ identity (cf. Bucholtz/Hall 2005; Pfaff-Czarnecka 2011). Besides vendors also commodify specific languages or multilingualism (Heller 2010) based on their and others’ language attitudes or they switch to a language for the purpose of maintaining the communication in sales conversations. Correlating these different factors, we will argue that code-switching is used with a commercial motivation in interactions between vendors and customers.
Urbanicity, Health, and Access to Services for People With Intellectual Disability and Developmental Disabilities
Authors: Fortney Stoni , Tassé Marc J.
Published: October 2021

Previous research suggests that residence in non-metropolitan areas is associated with lower access to preventive care and poorer health. However, this research has been largely restricted to the general population, despite data demonstrating disparities in health status and access to healthcare services for people with intellectual and developmental disabilities (IDD). The current study examined several hypotheses involving the effects of rurality on access to preventive healthcare and services and health status: (1) individuals in non-metropolitan areas will have lower preventive healthcare utilization, (2) individuals in non-metropolitan areas will have poorer health outcomes, and (3) individuals in non-metropolitan areas will have poorer access to services. The current study uses data from the National Core Indicators (NCI) Adult Consumer Survey 2015–2016: Final Report which included Rural-Urban Commuting Area (RUCA) Codes for the first time. Results of logistic regression suggest that, despite connection to disability services, the health status and access to preventive healthcare services of people with IDD generally follow patterns similar to those observed in the general population. Namely, people with IDD in non-metropolitan areas have decreased access to healthcare services, preventive healthcare utilization, and health status. Despite some exceptions, it appears effects of rurality are not completely mitigated by current state and federal efforts.
Preprocessing methods for quantitative phase image stitching
Authors: Stȩpień Piotr , Krauze Wojciech , Kujawińska Małgorzata
Published: October 2021

Quantitative phase imaging of cell cultures and histopathological slides often requires measurements in large fields of view which is realized through the stitching of multiple high resolution phase maps. Due to the characteristic properties of phase images, careful preprocessing is crucial for maintaining the metrological value of the stitched phase image. In this work, we present various methods that address those properties. Our efforts are focused on increasing robustness to minimize error propagation in consecutive preprocessing steps.
Circular polarization analyzer based on surface plasmon polariton interference
Authors: Qiu Peizhen , Bai Chunyan , Mao Yonghua , Zhang Dawei
Published: October 2021

The determination of chirality of circularly polarized light (CPL) is of great significance to the development of various optical techniques. In this paper, a miniature circular polarization analyzer (CPA) based on surface plasmon polariton (SPP) interference is proposed. The proposed CPA consists of a micron scale long sub-wavelength slit and two groups of spatially arranged periodic sub-wavelength rectangular groove pairs, which are etched in a metal layer. Under the illumination of a CPL with a given chirality, the proposed CPA is capable of forming SPP-mediated interference fringes with different periods in far field. The chirality of CPL can be directly and quantitatively differentiated by the frequency value of the far field SPP-mediated interference fringes. Different from the existing SPP-based CPAs, the proposed CPA can directly image the chirality information in far field, avoiding near-field imaging of the SPP field.
Millimeter-level resolution through-the-wall radar imaging enabled by an optically injected semiconductor laser
Authors: Sun Guanqun , Zhang Fangzheng , Pan Shilong
Published: October 2021

Millimeter-level resolution through-the-wall radar (TWR) imaging is demonstrated using a broadband nonlinear frequency-modulated (NLFM) signal that is generated by an optically injected semiconductor laser. The proposed system uses period-one dynamics of a semiconductor laser, together with an optical frequency downconversion technique to generate NLFM signals, which addresses the problem of traditional period-one oscillation not being able to generate broadband signals in the low-frequency region. In the experiment, an NLFM signal having a broad bandwidth of 18.5 GHz (1.5–20 GHz) is generated with a corresponding radar range resolution of 8.1 mm. Using this signal, TWR imaging is demonstrated, in which the use of the NLFM signal achieves good side-lobe suppression during pulse compression, and a modified back projection imaging algorithm with sub-aperture weighting is proposed to improve the imaging quality.
Towards a comprehensive lighting-quality model: validation of brightness, visual clarity, and color preference formulae applicability in two realistic mock-up scenarios
Authors: Klabes Julian , Babilon Sebastian , Beck Sebastian , Braun Swantje , Johannbroer Bruno , Joppien Anett-Maud , Trinh Quang Vinh , Khanh Tran Quoc
Published: October 2021

Provoking high user acceptance in lighting can be a very challenging task and demands suitable tools for properly modelling and predicting the users’ perception of the lit environment. Recently, a new model formalism based on the perceptually relevant attributes of perceived brightness, visual clarity, and color preference has been introduced and successfully applied in some preliminary studies. However, a proof of the model’s applicability from a lighting practitioner’s point of view for realistic lighting scenarios and use-cases is still pending and should be performed as part of this work. For this purpose, results of two dedicated lighting condition rating experiments representing different lighting contexts are reported. It is shown that the model predictions for all three perceptual attributes exhibit excellent linear correlations with the respective subject mean ratings and, in all cases, correctly predict the test light sources’ rank order. These results clearly emphasize the applicability and practical relevance of the model and confirm the suitability of its multi-dimensional approach.
Anti-parity-time symmetry enabled on-chip chiral polarizer
Authors: Wei Yanxian , Zhou Hailong , Chen Yuntian , Ding Yunhong , Dong Jianji , Zhang Xinliang
Published: October 2021

Encircling an exceptional point (EP) in a parity-time (PT) symmetric system has shown great potential for chiral optical devices, such as chiral mode switching for symmetric and antisymmetric modes. However, to our best knowledge, chiral switching for polarization states has never been reported, although chiral polarization manipulation has significant applications in imaging, sensing, communication, etc. Here, inspired by the anti-PT symmetry, we demonstrate, for the first time to our best knowledge, an on-chip chiral polarizer by constructing a polarization-coupled anti-PT symmetric system. The transmission axes of the chiral polarizer are different for forward and backward propagation. A polarization extinction ratio of over 10 dB is achieved for both propagating directions. Moreover, a telecommunication experiment is performed to demonstrate the potential applications in polarization encoding signals. It provides a novel functionality for encircling-an-EP parametric evolution and offers a new approach for on-chip chiral polarization manipulation.
On the optimality of the enzyme–substrate relationship in bacteria
Authors: Dourado Hugo , Mori Matteo , Hwa Terence , Lercher Martin J.
Published: October 2021

Much recent progress has been made to understand the impact of proteome allocation on bacterial growth; much less is known about the relationship between the abundances of the enzymes and their substrates, which jointly determine metabolic fluxes. Here, we report a correlation between the concentrations of enzymes and their substrates in Escherichia coli. We suggest this relationship to be a consequence of optimal resource allocation, subject to an overall constraint on the biomass density: For a cellular reaction network composed of effectively irreversible reactions, maximal reaction flux is achieved when the dry mass allocated to each substrate is equal to the dry mass of the unsaturated (or “free”) enzymes waiting to consume it. Calculations based on this optimality principle successfully predict the quantitative relationship between the observed enzyme and metabolite abundances, parameterized only by molecular masses and enzyme–substrate dissociation constants (Km). The corresponding organizing principle provides a fundamental rationale for cellular investment into different types of molecules, which may aid in the design of more efficient synthetic cellular systems.
The microbiome impacts host hybridization and speciation
Authors: Miller Asia K. , Westlake Camille S. , Cross Karissa L. , Leigh Brittany A. , Bordenstein Seth R.
Published: October 2021

Microbial symbiosis and speciation profoundly shape the composition of life’s biodiversity. Despite the enormous contributions of these two fields to the foundations of modern biology, there is a vast and exciting frontier ahead for research, literature, and conferences to address the neglected prospects of merging their study. Here, we survey and synthesize exemplar cases of how endosymbionts and microbial communities affect animal hybridization and vice versa. We conclude that though the number of case studies remain nascent, the wide-ranging types of animals, microbes, and isolation barriers impacted by hybridization will likely prove general and a major new phase of study that includes the microbiome as part of the functional whole contributing to reproductive isolation. Though microorganisms were proposed to impact animal speciation a century ago, the weight of the evidence supporting this view has now reached a tipping point.
Using ephaptic coupling to estimate the synaptic cleft resistivity of the calyx of Held synapse
Authors: Sierksma Martijn C. , Borst J. Gerard G.
Published: October 2021

At synapses, the pre- and postsynaptic cells get so close that currents entering the cleft do not flow exclusively along its conductance,gcl. A prominent example is found in the calyx of Held synapse in the medial nucleus of the trapezoid body (MNTB), where the presynaptic action potential can be recorded in the postsynaptic cell in the form of a prespike. Here, we developed a theoretical framework for ephaptic coupling via the synaptic cleft, and we tested its predictions using the MNTB prespike recorded in voltage-clamp. The shape of the prespike is predicted to resemble either the first or the second derivative of the inverted presynaptic action potential if cleft currents dissipate either mostly capacitively or resistively, respectively. We found that the resistive dissipation scenario provided a better description of the prespike shape. Its size is predicted to scale with the fourth power of the radius of the synapse, explaining why intracellularly recorded prespikes are uncommon in the central nervous system. We show that presynaptic calcium currents also contribute to the prespike shape. This calcium prespike resembled the first derivative of the inverted calcium current, again as predicted by the resistive dissipation scenario. Using this calcium prespike, we obtained an estimate forgclof ~1 μS. We demonstrate that, for a circular synapse geometry, such as in conventional boutons or the immature calyx of Held,gclis scale-invariant and only defined by extracellular resistivity, which was ~75 Ωcm, and by cleft height. During development the calyx of Held develops fenestrations. We show that these fenestrations effectively minimize the cleft potentials generated by the adult action potential, which might otherwise interfere with calcium channel opening. We thus provide a quantitative account of the dissipation of currents by the synaptic cleft, which can be readily extrapolated to conventional, bouton-like synapses.
Chromatin accessibility and gene expression during adipocyte differentiation identify context-dependent effects at cardiometabolic GWAS loci
Authors: Perrin Hannah J. , Currin Kevin W. , Vadlamudi Swarooparani , Pandey Gautam K. , Ng Kenneth K. , Wabitsch Martin , Laakso Markku , Love Michael I. , Mohlke Karen L.
Published: October 2021

Chromatin accessibility and gene expression in relevant cell contexts can guide identification of regulatory elements and mechanisms at genome-wide association study (GWAS) loci. To identify regulatory elements that display differential activity across adipocyte differentiation, we performed ATAC-seq and RNA-seq in a human cell model of preadipocytes and adipocytes at days 4 and 14 of differentiation. For comparison, we created a consensus map of ATAC-seq peaks in 11 human subcutaneous adipose tissue samples. We identified 58,387 context-dependent chromatin accessibility peaks and 3,090 context-dependent genes between all timepoint comparisons (log2 fold change>1, FDR<5%) with 15,919 adipocyte- and 18,244 preadipocyte-dependent peaks. Adipocyte-dependent peaks showed increased overlap (60.1%) with Roadmap Epigenomics adipocyte nuclei enhancers compared to preadipocyte-dependent peaks (11.5%). We linked context-dependent peaks to genes based on adipocyte promoter capture Hi-C data, overlap with adipose eQTL variants, and context-dependent gene expression. Of 16,167 context-dependent peaks linked to a gene, 5,145 were linked by two or more strategies to 1,670 genes. Among GWAS loci for cardiometabolic traits, adipocyte-dependent peaks, but not preadipocyte-dependent peaks, showed significant enrichment (LD score regression P<0.005) for waist-to-hip ratio and modest enrichment (P < 0.05) for HDL-cholesterol. We identified 659 peaks linked to 503 genes by two or more approaches and overlapping a GWAS signal, suggesting a regulatory mechanism at these loci. To identify variants that may alter chromatin accessibility between timepoints, we identified 582 variants in 454 context-dependent peaks that demonstrated allelic imbalance in accessibility (FDR<5%), of which 55 peaks also overlapped GWAS variants. At one GWAS locus for palmitoleic acid, rs603424 was located in an adipocyte-dependent peak linked to SCD and exhibited allelic differences in transcriptional activity in adipocytes (P = 0.003) but not preadipocytes (P = 0.09). These results demonstrate that context-dependent peaks and genes can guide discovery of regulatory variants at GWAS loci and aid identification of regulatory mechanisms.
A signature based on 11 autophagy genes for prognosis prediction of colorectal cancer
Authors: Chen Shuo , Wang Yan , Wang Boxue , Zhang Lin , Su Yinan , Xu Mingyue , Zhang Mingqing
Published: October 2021

Aim

To develop an autophagy-gene-based signature that could help to anticipate the therapeutic effects of Colorectal Cancer (CRC).

Methods

We downloaded the gene expression profiles of CRC samples from the Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) datasets. Genes with significant prognostic value in CRC were screened through univariate Cox regression analysis, while the LASSO Cox regression method was applied to screen optimal genes to construct the autophagy‐related prognostic signature.

Results

11 autophagy genes were identified and selected for the establishment of prognosis prediction model for CRC patients. The CRC patients were classified into the low- and high-risk groups according to the optimal cutoff value. The time-dependent ROC curves indicated the good performance of this model in prognosis prediction, with AUC values of 0.66, 0.66, and 0.67 at 1, 3 and 5 years for TCGA samples, as well as AUC values of 0.63, 0.65 and 0.64 for GEO samples, respectively. The multivariate Cox regression analysis results confirmed risk score as the independent marker for prognosis prediction in CRC. Besides, the constructed nomogram also had high predictive value. The results analysis on the tumor infiltrating immune cells (TIICs) relative ratios and mRNA levels of key immune checkpoint receptors indicated the signature was closely related to immune microenvironment of CRC in the context of TIICs and immune checkpoint receptors’ mRNA level. The proportion of MSI-L + MSI-H in the high-risk group was higher than that in the low-risk group. Moreover, the tumor purity was evaluated by estimate function package suggested that lower tumor purity in CRC might lead to a poorer prognosis.

Conclusion

The autophagy-related features obtained in this study were able to divide the CRC patients into low- and high-risk groups, which should be contribute to the decision-making of CRC treatment.
A bioinformatics pipeline for Mycobacterium tuberculosis sequencing that cleans contaminant reads from sputum samples
Authors: Cuevas-Córdoba Betzaida , Fresno Cristóbal , Haase-Hernández Joshua I. , Barbosa-Amezcua Martín , Mata-Rocha Minerva , Muñoz-Torrico Marcela , Salazar-Lezama Miguel A. , Martínez-Orozco José A. , Narváez-Díaz Luis A. , Salas-Hernández Jorge , González-Covarrubias Vanessa , Soberón Xavier
Published: October 2021

Next-Generation Sequencing (NGS) is widely used to investigate genomic variation. In several studies, the genetic variation ofMycobacterium tuberculosishas been analyzed in sputum samples without previous culture, using target enrichment methodologies for NGS. Alignments obtained by different programs generally map the sequences under default parameters, and from these results, it is assumed that onlyMycobacteriumreads will be obtained. However, variants of interest microorganism in clinical samples can be confused with a vast collection of reads from other bacteria, viruses, and human DNA. Currently, there are no standardized pipelines, and the cleaning success is never verified since there is a lack of rigorous controls to identify and remove reads from other sputum-microorganisms genetically similar toM.tuberculosis. Therefore, we designed a bioinformatic pipeline to process NGS data from sputum samples, including several filters and quality control points to identify and eliminate non-M.tuberculosisreads to obtain a reliable genetic variant report. Our proposal uses the SURPI software as a taxonomic classifier to filter input sequences and perform a mapping that provides the highest percentage ofMycobacteriumreads, minimizing the reads from other microorganisms. We then use the filtered sequences to perform variant calling with the GATK software, ensuring the mapping quality, realignment, recalibration, hard-filtering, and post-filter to increase the reliability of the reported variants. Using default mapping parameters, we identified reads of contaminant bacteria, such asStreptococcus,Rhotia,Actinomyces, andVeillonella. Our final mapping strategy allowed a sequence identity of 97.8% between the input reads and the wholeM.tuberculosisreference genomeH37Rvusing a genomic edit distance of three, thus removing 98.8% of the off-target sequences with aMycobacteriumreads loss of 1.7%. Finally, more than 200 unreliable genetic variants were removed during the variant calling, increasing the report’s reliability.
Slight dependence of temperate-forest herbaceous plants, Geum urbanum and Senecio ovatus, on arbuscular mycorrhizal fungi (AMF) enables them to colonise soils with a low level of AMF abundance
Authors: Rożek Katarzyna , Rola Kaja , Zubek Szymon
Published: October 2021

While numerous studies have revealed that arbuscular mycorrhizal fungi (AMF) enhance plant performance, the influence of these symbionts on temperate-forest herbaceous species in relation to soil physical and chemical properties has been left largely unexplored. Therefore, two perennial herbs, Geum urbanum (Rosaceae) and Senecio ovatus (Asteraceae), were examined in a laboratory pot experiment to determine whether AMF influenced their growth, photosynthetic performance index, and N and P contents in biomass. The treatments, involving three widespread AMF species, were prepared in the soils of two habitats colonised by both plants, namely beech and riparian forests, as follows: (1) control—soils without AMF, (2) Claroideoglomus claroideum, (3) Funneliformis geosporus, and (4) Funneliformis mosseae. Neither shoot mass nor photosynthetic performance index of G. urbanum and S. ovatus was enhanced by AMF. Senecio ovatus root mass was increased compared to control only by F. geosporus. Inconsistent effects were observed in N and P contents in shoots and roots of both species. The direction and magnitude of these responses were dependent on the fungal species and soil type. Although the plant species belong to families whose representatives are usually regularly colonised by and highly responsive to AMF, our study indicates that AMF had only a slight impact on the performance of G. urbanum and S. ovatus at the early stages of their development. The plants being slightly dependent on AMF are thus adapted to colonise temperate-forest soils with a low level of availability of AMF propagules.
Knowledge syntheses in medical education: Meta-research examining author gender, geographic location, and institutional affiliation
Authors: Maggio Lauren A. , Ninkov Anton , Costello Joseph A. , Driessen Erik W. , Artino Anthony R.
Published: October 2021

Introduction

Authors of knowledge syntheses make many subjective decisions during their review process. Those decisions, which are guided in part by author characteristics, can impact the conduct and conclusions of knowledge syntheses, which assimilate much of the evidence base in medical education. To better understand the evidence base, this study describes the characteristics of knowledge synthesis authors, focusing on gender, geography, and institution.

Methods

In 2020, the authors conducted meta-research to examine authors of 963 knowledge syntheses published between 1999 and 2019 in 14 core medical education journals.

Results

The authors identified 4,110 manuscript authors across all authorship positions. On average there were 4.3 authors per knowledge synthesis (SD = 2.51, Median = 4, Range = 1–22); 79 knowledge syntheses (8%) were single-author publications. Over time, the average number of authors per synthesis increased (M = 1.80 in 1999; M = 5.34 in 2019). Knowledge syntheses were authored by slightly more females (n = 2047; 50.5%) than males (n = 2005; 49.5%) across all author positions. Authors listed affiliations in 58 countries, and 58 knowledge syntheses (6%) included authors from low- or middle-income countries. Authors from the United States (n = 366; 38%), Canada (n = 233; 24%), and the United Kingdom (n = 180; 19%) published the most knowledge syntheses. Authors listed affiliation at 617 unique institutions, and first authors represented 362 unique institutions with greatest representation from University of Toronto (n = 55, 6%). Across all authorship positions, the large majority of knowledge syntheses (n = 753; 78%) included authors from institutions ranked in the top 200 globally.

Conclusion

Knowledge synthesis author teams have grown over the past 20 years, and while there is near gender parity across all author positions, authorship has been dominated by North American researchers located at highly ranked institutions. This suggests a potential overrepresentation of certain authors with particular characteristics, which may impact the conduct and conclusions of medical education knowledge syntheses.
Exploring gender differences in knowledge and practices related to antibiotic use in Southeast Asia: A scoping review
Authors: Pham-Duc Phuc , Sriparamananthan Kavitha
Published: October 2021

Inappropriate use of antibiotics has been one of the main contributors to antimicrobial resistance, particularly in Southeast Asia. Different genders are prone to different antibiotic use practices. The objective of this scoping review is to understand the extent and type of evidence available on gender differences in antibiotic use across Southeast Asia. The search strategy for this scoping review involved PubMed, Semantic Scholar, BioMed Central and ProQuest. Two-level screening was applied to identify the final sample of relevant sources. Thematic content analysis was then conducted on the selected final sources to identify recurring themes related to gender differences in antibiotic use and a narrative account was developed based on the themes. Recommendations for next steps regarding reducing inappropriate antibiotic use and gender considerations that need to be made when developing future interventions were also identified. Research on gender and antibiotic use remains scarce. Studies that discuss gender within the context of antibiotic use often mention differences between males and females in knowledge, attitudes and/or behaviour, however, do not explore reasons for these differences. Gender differences in antibiotic use were generally examined in terms of: (i) knowledge of antibiotic use and antimicrobial resistance and (ii) practices related to antibiotic use. Evidence indicated that differences between males and females in knowledge and practices of antibiotic use varied greatly based on setting. This indicates that gender differences in antibiotic use are greatly contextual and intersect with other sociodemographic factors, particularly education and socioeconomic status. Educational interventions that are targeted to meet the specific needs of males and females and delivered through pharmacists and healthcare professionals were the most common recommendations for reducing inappropriate use of antibiotics in the community. Such targeted interventions require further qualitative research on factors influencing differences in knowledge and practices related to antibiotic use among males and females. In addition, there is also a need to strengthen monitoring and regulation practices to ensure accessibility to affordable, quality antibiotics through trusted sources.
The value of blue-green algae (Spirulina platensis) as a nutritive supplement and toxicant against almond moth [Cadra cautella (Lepidoptera: Pyralidae)]
Authors: Al-Qahtani Wahidah H.
Published: October 2021

Blue-green algae, Spirulina platensis is a well-known algal formulation known for its beneficial effects on the growth and development in several types of organisms. Although it is used as a food supplement, it possesses significant toxic effects on growth and development of organisms. This study assessed the positive/negative impacts of S. platensis on almond moth, Cadra cautella (almond moth) that is a serious pest of date fruits and other grains under laboratory conditions. The S. platensis powder were mixed with diet and newly hatched C. cautella larvae were fed. The larvae were observed on alternate days to record the data. The diet was changed once a week. The S. platensis proved very good nutrition supplement at lower dose. Whereas, moderate and high mortality was noted for 5 and 10% formulations, respectively. Moreover, larval span was significantly altered by different formulations and lower formulation (1%) resulted in shorter larval period compared to the rest of the formulations. Although 33% mortality was recorded under 5% S. platensis formulation, however, the larvae which reached to adult stage, copulated, and females laid more eggs. Furthermore, the highest mortality (90%) was observed under 10% S. platensis formulation and a few larvae reached adult stage; thus, no data on pupal period and reproductive traits was recorded for this formulation. These findings proved that S. platensis can be used as nutritional supplement as well as a toxic substance to manage C. cautella in date storage. However, future studies on this are needed to reach concrete conclusions.
Reopening California: Seeking robust, non-dominated COVID-19 exit strategies
Authors: Nascimento de Lima Pedro , Lempert Robert , Vardavas Raffaele , Baker Lawrence , Ringel Jeanne , Rutter Carolyn M. , Ozik Jonathan , Collier Nicholson
Published: October 2021

The COVID-19 pandemic required significant public health interventions from local governments. Although nonpharmaceutical interventions often were implemented as decision rules, few studies evaluated the robustness of those reopening plans under a wide range of uncertainties. This paper uses the Robust Decision Making approach to stress-test 78 alternative reopening strategies, using California as an example. This study uniquely considers a wide range of uncertainties and demonstrates that seemingly sensible reopening plans can lead to both unnecessary COVID-19 deaths and days of interventions. We find that plans using fixed COVID-19 case thresholds might be less effective than strategies with time-varying reopening thresholds. While we use California as an example, our results are particularly relevant for jurisdictions where vaccination roll-out has been slower. The approach used in this paper could also prove useful for other public health policy problems in which policymakers need to make robust decisions in the face of deep uncertainty.
Microbiota instruct IL-17A-producing innate lymphoid cells to promote skin inflammation in cutaneous leishmaniasis
Authors: Singh Tej Pratap , Carvalho Augusto M. , Sacramento Laís Amorim , Grice Elizabeth A. , Scott Phillip
Published: October 2021

Innate lymphoid cells (ILCs) comprise a heterogeneous population of immune cells that maintain barrier function and can initiate a protective or pathological immune response upon infection. Here we show the involvement of IL-17A-producing ILCs in microbiota-driven immunopathology in cutaneous leishmaniasis. IL-17A-producing ILCs were RORγt+ and were enriched in Leishmania major infected skin, and topical colonization with Staphylococcus epidermidis before L. major infection exacerbated the skin inflammatory responses and IL-17A-producing RORγt+ ILC accumulation without impacting type 1 immune responses. IL-17A responses in ILCs were directed by Batf3 dependent CD103+ dendritic cells and IL-23. Moreover, experiments using Rag1-/- mice established that IL-17A+ ILCs were sufficient in driving the inflammatory responses as depletion of ILCs or neutralization of IL-17A diminished the microbiota mediated immunopathology. Taken together, this study indicates that the skin microbiota promotes RORγt+ IL-17A-producing ILCs, which augment the skin inflammation in cutaneous leishmaniasis.
Oralizations in e-mail consultations: A study of general practitioners’ use of non-verbal cues in written doctor–patient communication
Authors: Nordtug Maja , Møller Jane Ege , Matthiesen Signe Schlichting , Brøgger Matilde Nisbeth
Published: October 2021

It is well-known that non-verbal cues are essential in doctor–patient communication. As doctor–patient communication is turning increasingly digital and written, it becomes relevant to explore the role of non-verbal cues in such communication genres. One more recent genre is the doctor–patient e-mail consultation. Research has found that while patients like e-mail consultations, they also miss facial expressions, eye contact, etc. In this study, we explored the different ways in which Danish GPs use non-verbal cues in e-mail consultations. We analysed 633 e-mail consultations written by 22 GPs. We applied the concept oforalization, which includes the use of emoticons and non-standard use of grammar and spatial arrangement. We found that the dominant types of oralizations were non-corrected spelling errors and lack of attention to capitalization. Overall, GPs used a limited number of other non-verbal cues. We discuss how these findings relate to norms of formality and professional context.
Appreciating ‘schizophrenics’ online: Identification in mHealth
Authors: Sánchez Valle Francisco
Published: October 2021

Medical science not only affects our lives in terms of health and disease but also transforms our more vital experiences. Nowadays, this statement has acquired special significance, given the adoption of information and communication technologies (ICT) by medical practice, the so-called eHealth. The great growth in the use of smartphone applications for managing mental distress has been coined as ‘pocket psychiatry’. Within this digital scape, many disease-specific apps such as ClinTouch, aimed at the self-management of psychosis, have been launched in the market. By using the analytical concept of ‘script’, the article aims to show how the psychiatric world-view embedded in ClinTouch defines a particular framework of action for ‘schizophrenic’ users to contest ‘external-identifications’. It is suggested that if the main endeavour is to promote mental health in the community, it is needed to go beyond the biomedical model to maximize the social participation of people with mental suffering in the use of ICT.
Platformization of healthcare communication: Insights from the early stage of the COVID-19 pandemic in Italy
Authors: Locatelli Elisabetta , Lovari Alessandro
Published: October 2021

Over the past few years, public health organizations have adopted new communication practices, such as social media communication, framed by the concepts of Health 2.0 and Medicine 2.0. These concepts need to be reconsidered in the light of the transformation of social media as digital platforms. This article aims to define and critically discuss the concept of the platformization of healthcare communication, investigating the impact of social media incorporation on the local health authorities’ Facebook communication during the early phase of the COVID-19 emergency in Italy. Findings show the progressive incorporation of the mechanisms of platformization by local health authorities and the progressive shift of their Facebook pages from connectors to complementors of healthcare communication and services during the early phase of the pandemic. Conclusions critically discuss the incorporation of social media into the communication strategies of the public healthcare sector.
A flight of no substance, collapsing space in its wake
Authors: Eeckhout Riet
Published: October 2021

This article looks at ways in which architecture can be articulated as a sensation within the drawing. The subject of occupying drawings is considered here as a result of entering the drawing, an action John Hejduk describes ‘as a flight of no substance’, collapsing space between the observer and the artefact in its wake. Entering the drawing and subsequently occupying the drawing is considered here as a phenomenon that enables experiential and observational proximity to an artefact and its embedded subject. The collapsing mechanism enforces thinking about the observational intent of this type of entering, its relationship with immediacy and with aspects of the non-representational. Furthermore, the act of entering the drawing is viewed as a technique for mediating and bringing forth subject matter in the drawing. This technique of augmented observation and mediation is in service of the quest for subject presence in the drawing, as opposed to subject representation in the drawing – allowing a residence in close encounter by the maker during production and later by the observer of the resulting artefact. The article is accompanied by a set of drawings from the Drawing Out Gehry series. The drawings are driven by an interest in relational encounters and space they take in. Away from an object or component-directed perception of space and towards the understanding of space as the relationship between elements, this set of drawings is in search of the quality and intrigue raised by the architectural event as the encounter of spatial circumstances.
Catalan editions in resistance: The publication of testimonial narrative about French concentration camps in Catalan during Franco’s dictatorship
Authors: Simón Paula
Published: October 2021

As part of its repressive programme, Franco’s regime significantly limited the publication of literature in Catalan, a language that was pejoratively reduced to the category of dialect. In that context, the decision of writing and editing books in Catalan during the military dictatorship (1939–75) was itself an act of resistance. This article studies a series of testimonial narratives that were published in the late 1960s and early 1970s in Spain about French concentration camps, including Crist de 200.000 braços. Refugiats catalans als camps de concentració francesos (1968), by Agustí Bartra; El desgavell (1969), by Ferran Planes; and Cartes des dels camps de concentració (1972), by Pere Vives i Clavé. Testimonial narratives about French concentration camps already circulated in the countries where Spanish intellectuals were exiled. However, writers such as Bartra, Planes, Vives i Clavé (survivors of Argelès-sur-Mer, Saint-Cyprien and other French concentration camps) and some Catalan editors committed to the Republican cause were interested in telling their traumatic experiences to Spanish and Catalan readers living in Spain. Therefore, they undertook the task of editing these works although in many cases they were strongly censored. Taking this into account, the purpose of this article is to analyse some aspects of these editions in order to consider how their testimonial narratives remain in constant tension between two forces: Republican writers’ intention to show their own version of recent history and the Spanish government’s imposition of its own institutional and conservative official discourse.