bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular characterization and epidemiology of methicillin-resistant Staphylococcus aureus isolated from clinical samples in Sokoto, Nigeria
Authors: Umar Asiya Imam , Manga Shuaibu Bala , Baki Aliyu Sarkin , Uba Ahmad
Published: June 2023

Objectives:

Methicillin-resistant Staphylococcus aureus (MRSA) is a major public health threat and a cause of hospital-acquired and community-acquired infections. This study was undertaken to investigate antimicrobial resistance pattern, the genetic lineage, presence of S. aureus protein A (SPA) gene, and staphylococcal chromosomal cassette mec (SCC mec) types of MRSA isolated from clinical samples sent for microbiological test in major government hospitals in Sokoto.

Material and Methods:

A total of 90 S. aureus MRSA isolates were collected and confirmed using standard microbiological techniques. Antibiotic susceptibility testing was done using the disk diffusion method; mecA detection and sequencing were carried out. Phylogenetic reconstruction was also done using the molecular evolutionary genetics analysis X software and phylogeny tree constructed by Neighbor-Joining method. SCC mec typing and SPA detection were also done.

Results:

Of the 90 S. aureus isolates, 42 were found to be MRSA using the cefoxitin disk diffusion, the most potent antibiotic against them was quinupristin/dalfopristin with 83.3% followed by rifampicin with 81.0% and 6 clindamycin with a 71.4%. With 78.6% of the isolates showing resistance to the fluoroquinolone antibiotic ciprofloxacin, tetracycline and gentamicin came in second and third, with 64.3% and 61.9% of isolates showing resistance, respectively. Most of the MRSA isolates were resistant to more than three antibiotics. Polymerase chain reaction showed 36 (85.7%) harbored the mecA gene and of the 36 mecA positive isolates, phylogenetic reconstruction of representative MRSA sequences showed that MRSA sequences in this study clustered in two closest clades suggesting a possible horizontal transfer. Of the 36 isolates, 23 were SCC mec type I, ten were type IV, and three were non-typeable, while the SPA gene was detected in all the isolates amplified.

Conclusion:

The use of phenotypic and molecular methods in this study provided useful information on antibiotic resistance profile, epidemiology, and molecular characteristics of MRSA isolates in Sokoto Nigeria. The information provided could help in monitoring the evolution of MRSA strains in Nigeria over time.
Bilateral acute angle closure attack precipitated with dengue fever
Authors: Kaur Rajwinder , Kaur Mandeep , Dahiya Priyanka , Kaur Harleen
Published: June 2023

Dengue is known to cause varied ocular problems from mild-to-severe sight threatening. We present the case of a 63-year-old female patient with bilateral shallow anterior chamber and acute angle closure attack precipitated during the convalescent phase of dengue infection. She arrived at the emergency department at midnight with a history of vomiting, headache, weakness, and pain in the left eye (LE). Her diagnosis of dengue fever was supported by specific serological testing. On ocular examination, the anterior chamber of both eyes was noticeably shallow and her LE felt stony hard on digital palpation. Intravenous mannitol 300 mL over 45 min were given stat followed by topical medications. In the morning, intraocular pressure measured was 10 mmHg (right eye [RE]) and 26 mmHg (LE). After thorough examination, she was diagnosed with occludable angle in RE and angle closure in LE after gonioscopy. Neodymium-doped Yttrium Aluminum Garnet laser peripheral iridotomy was done in both eyes. She was relieved of symptoms. The varied spectrum of possible ocular symptoms should prompt the ophthalmologist to suspect the potential involvement of eye in dengue fever. Detailed history taking is of utmost importance in early diagnosis of some rare presentation of dengue-related ophthalmic involvement. Increased awareness of dengue-related ophthalmic complications among clinicians involved in the care of patients with dengue would facilitate prompt ophthalmologic assessment and emergency medical care.
Tofacitinib in the treatment of recalcitrant cases of psoriasis vulgaris
Authors: Sharma Richa , Dhurat Rachita S. , Maanasa M. , Ghate Smita Sunil
Published: June 2023

Treatment of recalcitrant cases of psoriasis vulgaris can pose a major challenge to dermatologists. Despite the availability of various drugs and treatment modalities, these cases often either show unsatisfactory response to these treatments or may have to be discontinued due to development of adverse effects or may be contraindicated due to underlying morbidities. After exhausting the conventional modalities such as methotrexate, cyclosporine, acitretin, apremilast, and phototherapy, the next line of management involves usage of biologicals. Biologicals, although efficacious in most cases, come with their own set of drawbacks including cost, availability, and risk of development of anti-drug antibodies, rendering them ineffective. Furthermore, some patients have found to relapse within a few months of stopping them. We present a case series of five patients of refractory psoriasis vulgaris who had exhausted all conventional modalities (including biologicals in three of the patients) who were successfully treated with tofacitinib, a small molecule inhibiting Janus kinase 1/3 enzyme. Our patients have reported no side effects with tofacitinib till date and are continuing to maintain the results. From this series, we conclude that tofacitinib may be an effective therapy for the management of recalcitrant psoriasis.
A Case of an Aggressive Triple Negative Metastatic Metaplastic Breast Cancer
Authors:   Department of Surgery, University Hospital “Tzaritza Joanna – ISUL”, Medical University of Sofia, Bulgaria, TA Sedloev , SS Usheva ,   Department of Surgery, University Hospital “Tzaritza Joanna – ISUL”, Medical University of Sofia, Bulgaria, JV Spirdonov ,   Department of Medical imaging, University Hospital “Tzaritza Joanna – ISUL”, Medical University of Sofia, Bulgaria, KS Grozdev ,   Department of General Surgery – MBAL “Sveta Sofia”, Sofia, Bulgaria, K Koleva ,   Department of Medical Oncology – MBAL “Sveta Sofia”, Sofia, Bulgaria
Published: June 2023

Introduction: We present a case of a 69 years old Bulgarian patient with a Triple Negative (TN) MBC. One year after the Breast-Conserving Surgery (BCS), adjuvant chemo- and radiotherapy she was diagnosed with metastases in the sigmoid colon, mesosigmoid, loco-regional lymph nodes and in the brain. Case report: The patient was initially diagnosed with locally advanced TNBC of the left breast in March 2021. She had undergone 6 courses of neoadjuvant chemotherapy and BCS with axillary lymph node dissection on 15.07.2021. The patient had received 4 courses of CarboTAx and whole breast radiation therapy postoperatively until December 2021. Eight months after that she was diagnosed with large bowel lesion in the sigmoid and a second small one in the mesosigmoid on the follow up PET/CT. She was admitted and had undergone laparoscopic left hemicolectomy. Due to signs of central system disorder (headache, impaired vision and vertigo) she was sent to additional examination with MRI (17.10.2022). Several heterogenous formations were found in the supratentorial space. Discussion: TNBC presents an aggressive subgroup, associated with worse prognosis and in about 30-40% of the cases early metastases and recurrence are observed. MBCs have poor response rates to cytotoxic chemotherapy compared to other types of BC. Conclusion: The presented case is here to show the unpredictable biological behaviour of this pathology regardless of the adequate treatment plan and careful follow up and to remind the physicians to be permanently aware of the numerous manifestations of the disease.
MGMT Methylated High Grade Glioma with Distant Recurrence and Stable Original Tumor Site: Case Series
Authors:   Department of Neurological Surgery, Loyola University Medical Center/Stritch School of Medicine, Maywood, IL, USA, Lee Jonathan , Lukas Rimas V ,   Department of Neurology, Northwestern University, USA, Jusue-Torres Ignacio ,   Department of Neurological Surgery, Loyola University Medical Center/Stritch School of Medicine, Maywood, IL, USA, Germanwala Anand V ,   Department of Neurological Surgery, Loyola University Medical Center/Stritch School of Medicine, Maywood, IL, USA, Borys Ewa ,   Department of Pathology, Loyola University Medical Center/Stritch School of Medicine, Maywood, IL, USA, Solanki Abhishek A ,   Department of Radiation Oncology, Loyola University Medical Center/Stritch School of Medicine, Maywood, IL, USA, Mallik Atul K ,   Department of Radiology, Loyola University Medical Center/Stritch School of Medicine, Maywood, IL, USA, Barton Kevin ,   Department of Hemato-oncology, Loyola University Medical Center/Stritch School of Medicine, Maywood, IL, USA, Thakkar Jigisha P ,   Department of Neurological Surgery, Loyola University Medical Center/Stritch School of Medicine, Maywood, IL, USA
Published: June 2023

We present three cases of O6-Methylguanine-DNA Methyltransferase (MGMT) methylated high grade gliomas with distant recurrence. All three patients had a radiographic stability of original tumor site at time of distant recurrence indicating impressive local control with Stupp protocol in patients with a MGMT methylated tumors. All patients had a poor outcome after distant recurrence. For one patient Next Generation Sequencing (NGS) was available for both original and recurrent tumor and did not reveal any difference other than high tumor mutational burden in the distant recurrent tumor. Understanding risk factors of distant recurrence in MGMT methylated tumors and investigating correlations between recurrences will help plan therapeutic strategies to prevent distant recurrence and improve survival of these patients.
CML with De Novo NPM1 Mutation and Rapid Progression to Myeloid Blast Cri-Sis despite Treatment with Imatinib: A Case Report
Authors:   Department of Haematology, Northampton General Hospital, UK, B Chaudhry , J Parker ,   Department of Haematology, Northampton General Hospital, UK, M Altohami ,   Department of Haematology, Leicester Royal Infirmary, Infirmary Square, UK, I Borghi ,   Department of Haematology, Leicester Royal Infirmary, Infirmary Square, UK
Published: June 2023

In this case we present a 41 year old male with chronic myeloid leukaemia who despite scoring low risk for Sokal progressed rapidly to blast crisis without warning and after having achieved a partial response to Imatinib therapy. We investigated using retrospective Next Generation Sequencing (NGS) and identified a novel NPM1 mutation at diagnosis and blast crisis together. We also found tyrosine kinase domain mutations using NGS not found with Sanger sequencing. We believe this case highlights the effectivity of NGS in identifying novel and existing mutations with higher sensitivity, which could help improve existing practice in prognostication and management of CML disease in patients not responding to treatment adequately.
On-resin Photochemical Decarboxylative Arylation of Peptides
Authors: Pal Sunit , Openy Joseph , Krzyzanowski Adrian , Noisier Anaïs , 't Hart Peter
Published: June 2023

Here we describe the application of photochemical decarboxylative arylation as a late-stage modification reaction for peptides. The reaction uses redox active esters of aspartic acid and glutamic acid on solid phase to provide analogues of aromatic amino acids. By using aryl bromides as arylation reagents a wide variety of amino acids can be accessed without having to synthesize them individually in solution. The reaction is compatible with proteinogenic amino acids and was used to perform a structure-activity relationship study on a PRMT5 binding peptide.
Keputusan Hakim Syarie Dalam Kes-Kes Pengesahan Hibah Ruqba
Authors: Azalan Nurul Syuhadah , Mohamed Said Noor Lizza
Published: June 2023

Permohonan kes pengesahan hibah di Mahkamah Syariah meliputi isu hibah ruqba. Di Mahkamah Syariah, Hakim-hakim Syarie akan membuat keputusan bagi kes-kes pengesahan hibah dengan berpandukan kepada kitab-kitab fiqh sedangkan terdapat pelbagai pendapat dalam kalangan fuqaha mengenai hibah termasuk berkaitan dengan isu hibah ruqba. Konsep hibah ruqba yang berbeza dengan kaedah asal hibah menjadi persoalan yang perlu dirungkai. Timbul juga persoalan adakah hibah ruqba dibolehkan menurut pendapat para fuqaha di samping melihat pengamalan hibah ruqba di Malaysia. Justeru, artikel ini adalah bertujuan untuk mengetahui keputusan yang dibuat oleh Hakim-hakim Syarie di samping mengetahui kecenderungan penghakiman Hakim-hakim Syarie dalam mengguna pakai pandangan fuqaha bagi menyelesaikan kes-kes pengesahan hibah mengenai isu hibah ruqba di Mahkamah Syariah. Data-data kajian ini diperoleh daripada laporan-laporan kes di Mahkamah Syariah, perbandingan mazhab dan temubual Hakim-hakim Syarie. Hasil kajian mendapati terdapat perbezaan pandangan daripada Hakim-hakim Syarie dalam menentukan keputusan kes-kes pengesahan hibah mengenai isu hibah ruqba seperti keputusan yang dibuat oleh Hakim Syarie yang telah meluluskan pengesahan hibah. Oleh yang demikian, dengan mengetahui keputusan Hakim Syarie dalam memutuskan isu hibah ruqba, ia dapat memberi garis panduan kepada masyarakat dan syarikat-syarikat yang menawarkan produk hibah. Kata kunci: ruqba, Mahkamah Syariah, hibah, Hakim Syarie, keputusan
The Fight against the Plague of Cattle in the Yenisei Province at the End of the 19th Century (Based on the Materials of the Khakass Foreign Management Bodies)
Authors:   Khakas State University named after N. F. Katanov, Mamysheva E. P.
Published: June 2023

The article considers the measures taken by the bodies of the Khakass Indigenous SelfGovernment to combat the epizootic outbreak of the plague. The author notes that the plague caused significant damage to the cattle-breeding economy of the Khakass (the Minusinsk and Achinsk indigenous dwellers of the Yenisei Governorate (before 1917)). The bodies of the Cattle Breeders’ Indigenous Management together with the provincial and district authorities made enormous efforts to stop the plague epizootic at the end of the 19th century. The imperial authorities developed a whole range of measures; in the indigenous environment, explanatory work about the need to carry out actions to help overcome the plague epidemic of cattle was carried out.
The First in Siberia: To the 80th Anniversary of the Irkutsk Dissertation Council in History
Authors:   Transbaikal State University, Mamkina I. N.
Published: June 2023

The review gives a positive assessment of the monograph, which represents the 80- year development of the Dissertation Council in Historical Sciences at the ISU. The authors examined the history of the Council in the context of the state policy implementation in the field of science and education. The monograph presents a broad biographical base, supplemented by personal memoirs of council members. It is highlighted that the authors have convincingly proved the leading role of the Council in the training of highly qualified personnel for the Siberian region.
MAPPING OF EROSION HAZARD VULNERABILITY BASED ON GIS AND USLE IN WAIRUTUNG WATERSHED, SALAHUTU DISTRICT, CENTRAL MALUKU REGENCY
Authors: Lasaiba Mohammad Amin Lasaiba
Published: June 2023

This study aims to assess the erosion hazard level in the Wairutung Watershed. This study uses the results of overlaying land use maps, slope maps, and soil types maps to generate the Land unit, which is the unit of analysis. Done using a computer-based Geographic Information System (GIS) with the ArcGIS program integrated with the Universal Soil Loss Equation (USLE) model. The sum of the results of the rating of the parameters then determines the class of vulnerability. The results obtained from this study indicate the division of 4 categories of landslide hazards consisting of a very light course with an area of 2900,865 ha spread over land units with alluvial soil types. The medium type, with a total area of 3683.285 ha, is distributed over land units with podzolic soil types. Heavy type with a total area of 1458.367 ha and the whole place is spread over land units with podzolic and cytosol soil types. The erosion hazard level is hefty, with a total area of 421.97 ha, and is spread over land units with podzolic and cytosol soil types.
Keywords: Erosion, Vulnerability, and USLE
Impact of the First-Year Seminar Course on Student GPA and Retention Rate across Colleges in Qatar University
Authors: Elobaid Manal , Elobaid Rafida M , Romdhani Lamia , Yehya Arij
Published: June 2023

The first year is known to be challenging for students at university. If students fail to transition to college successfully, it can result in a low GPA and they may eventually drop out of university. Fortunately, higher education systems opt to add various types of support for students during this important transition. One possible support is to implement a first-year seminar course, a hybrid-course which teaches academic and non-academic skills that help students to be successful. Optimally, teaching students’ skills for college success might help them manage their academic needs and increase retention rates. Following this proposal for best practice, Qatar University added a compulsory first-year seminar course in six colleges across different programs. The course included cognitive, non-cognitive and performance skills. In this retrospective study, we assessed the impact of this course on the retention rate at the university and students’ academic performance over time. We reviewed a large sample of over 3000 students who started their college journey at Qatar University over four consecutives semesters. Students were classified into two groups to allow for comparison between those who took the first-year seminar course and those who did not take it, in terms of their retention rates and GPA. Our findings show that students who successfully completed the course had a higher retention rate, especially in the first semester. Furthermore, the GPA, for those who took the course and continued to attend the university, was higher across semesters. In conclusion, within our sample, the first-year seminar course was successful in supporting student success as evidenced by higher GPAs, and an increased retention rate.
Understanding the Demand for Industrial skills through the National Certificate (Vocational) Building and Civil Engineering Programme
Authors: Nkwanyane Themba Paulos
Published: June 2023

The Ministry of Higher Education and Training has significantly transformed the technical and vocational education and training sector to respond to socio-economic ills such as poverty, unemployment and inequalities. With the mission of the White Paper for Post-School Education and Training, TVET programmes are prioritised as a significance in responding to societal challenges by offering skills that are aligned to industry to enable youth and young adults to successfully enter the industry for their sustainable livelihoods. This study provides a critical analysis on alignment of the National Certificate (Vocational): Building and Civil Engineering programme) offered by TVET Colleges. This article is based on a case study of two vocational training institutions in Mpumalanga Province, South Africa. A qualitative research approach was followed. The article used interviews and observations as data collection tools. The population for the study consisted of ten TVET teachers. The data were analysed by transcribing the data, coding, and thematic discussion using thematic analysis. The study's findings show that the NCV: Building and Civil Engineering programme is not aligned with the industry, as the workshop’s practical training is given inadequate time. The NCV: Building and Civil Engineering programme contains too many theoretical sections. The theoretical part is mainly offered to the students rather than hands-on practical training. The study concludes that the TVET sector faces challenges to meet the demand for industrial skills. This study recommends that the NCV program be evaluated urgently to address this issue and to ensure that it remains aligned with industry.
Medicina ambulatoria. Aspectos fundamentales de la medicina general
Authors: Alcívar López Elvis Enrique , Arteaga Castro Yadira Xiomar , Paredes Muñoz Betsy Alexandra , Merchán Zavala Diana Elizabeth
Published: June 2023

La Medicina Preventiva comprende como principios: las atenciones de salud y las de Atención Médica. La formación del médico se realizaba atendiendo a los enfermos en los hospitales; el desarrollo de la Atención Primaria de salud ha posibilitado la formación en las comunidades con el objetivo esencial de la atención a la salud de la población. La metodología utilizada para el presente trabajo de investigación. La técnica para la recolección de datos está constituida por materiales electrónicos, estos últimos como Google Académico, entre otros, apoyándose para ello en el uso de descriptores certificados y avalados por el tesauro de la UNESCO. La información aquí obtenida será revisada, resumida y analizada para su exposición organizada en los resultados. Los aspectos fundamentales de la medicina general es que tiene la capacidad dentro de su acción vertical de delegar incidencias a otras especialidades y centros de salud que lo ambulatorio no tiene la capacidad de atender, por ello la importancia de los médicos generales e internistas en estos procesos de captación y filtro a la hora de la atención primaria a la población. Sin embargo, el sistema a manera integral no puede funcionar si en primera instancia no existen la cantidad de centros de salud necesarios por cantidad de habitantes al igual que médicos y enfermeras, sin dejar de restarle importancia a los insumos médicos.
La importancia de la seguridad informática en la educación digital: retos y soluciones
Authors: Guaña-Moya Javier
Published: June 2023

La seguridad informática es esencial en la educación digital para proteger la información y garantizar su integridad, confidencialidad y disponibilidad. Se han realizado diversos estudios sobre este tema, resaltando la aplicación de normas internacionales como la ISO/IEC 27002:2013 en instituciones educativas y su papel crucial en el ámbito académico y los sistemas de información. Para enfrentar las amenazas en seguridad informática, se enfatizan las buenas prácticas, especialmente entre los usuarios, considerados la principal vulnerabilidad. Se ha desarrollado un recurso educativo digital para abordar el ciberbullying y se utilizan técnicas de inteligencia artificial para analizar riesgos en educación superior. En la gestión pedagógica, la seguridad informática es una competencia digital docente clave que debe ser abordada integralmente. Se destaca la importancia de una agenda educativa digital en América Latina para enfrentar los desafíos actuales en la educación superior. Los estudios se han centrado en la auditoría de seguridad informática, y en soluciones holísticas para mejorar la gestión de tecnologías de la información y la comunicación en el ámbito educativo. Se proponen planes de gestión de seguridad basados en normas reconocidas como ISO 27001. En síntesis, la seguridad informática desempeña un papel fundamental en la educación digital, destacado por diversos estudios; las soluciones propuestas incluyen la aplicación de normas internacionales, la implementación de buenas prácticas, el análisis de riesgos y vulnerabilidades, y la capacitación en competencias digitales, por lo que, es esencial promover una cultura de seguridad informática en el ámbito educativo para proteger la información y garantizar un entorno digital seguro para estudiantes, docentes y padres de familia.
Satisfacción del usuario y las dimensiones de la calidad de la atención del servicio de emergencia del Hospital Regional de Tumbes
Authors: Delgado Medina Luz María , Calero Zea María Auxiliadora , Noriega Martínez Sheilla Catherine , Castillo Valdiviezo Carmen Victoria
Published: June 2023

El Hospital Regional de Tumbes es una institución de segundo nivel atención con categoría II–2, que brinda atención de acuerdo a su categoría. Los principales objetivos de la auditoria de la calidad de atención están orientados a mejorar el cuidado del paciente considerando las 5 dimensiones teóricas en las que se enmarca la calidad. Conscientes de los recursos limitados que existen en la región, con serias limitaciones para su funcionamiento y baja cobertura de servicios de salud, existe la necesidad de brindar una atención de calidad que contribuya a disminuir la tasa de morbimortalidad infantil y materna, así como mejorar el grado de satisfacción de los usuarios del sistema de salud y las denuncias por presuntas negligencias médicas. Se hace necesario establecer acciones a través del plan de Implementación de la Norma Técnica de Auditoría a fin de mejorar el desempeño de los profesionales en los procesos de la atención en salud. El presente estudio propone conocer la satisfacción del usuario y las dimensiones de calidad del servicio brindado en el paciente del servicio emergencia del Hospital Regional de Tumbes-2022 a través del diseño con enfoque de tipo cuantitativo no experimental delimitado a una población de 418 pacientes que asistieron al servicio de emergencia del referido centro de asistencia médica. Es necesario capacitar al personal sobre las dimensiones de la satisfacción y la calidad, permitiendo mejoras en el conocimiento científico y en la atención. Luego de ello el monitoreo y evaluación permanente de la calidad de atención representa un indicador para conocer el buen servicio que brinda el hospital puesto que al momento de esta investigación destaca que más del 55% de los encuestados perciben como regular la calidad de atención.
Uji Kelayakan E-LKPD Berbasis PBL (Problem Based Learning) Untuk Meningkatkan Keterampilan Proses Sains Peserta Didik SMA
Authors: Khairunnisa Novia , Purwanto Andik , Medriati Rosane
Published: June 2023

This study aims to determine the validity of PBL (Problem Based Learning) based E-LKPD to improve the science process skills of high school students. By using the type of R&D (Research and Development) method and consists of a process of (1) Analysis, (2) Design, and (3) Develop. This research instrument is a material expert validation sheet and a media expert validation sheet to determine the validity of E-LKPD. This study tested of E-LKPD with static electricity class XII material and was conducted at SMA Negeri 3 Bengkulu City, SMA Negeri 4 Bengkulu City, and SMA Negeri 9 Bengkulu City. Based on the data analysis that has been done, it is found that the results of the material E-LKPD validation are 88,3% with worthy criteria. While the results of media E-LKPD validation are 80% with worthy criteria. While the material reliability test results are 79% with reliable criteria and the media reliability test results are 94% with reliable criteria.  So, it can be concluded that the PBL (Problem Based Learning) based E-LKPD to improve the science process skills of high school students is said to be worthy.  Keywords: feasibility test of E-LKPD, PBL, Science Process Skills.
Yığma yapıların düzlem dışı davranışlarına yan duvarın ve yan duvar boşluğunun etkisi
Authors: KIPÇAK Fırat , ERDİL Barış
Published: June 2023

Yığma yapılar teknik bilgi içermeden yapılan bu yapılar yaşanan depremler nedeniyle oldukça hasar görmekte ve göçmektedir. Yığma yapı taşıyıcı sistemini oluşturan duvarlar malzeme, işçilik, harç, duvar narinliği, duvarda bulunan boşluklar ve düzlem içi/dışı konumu gibi parametrelerden etkilenmektedir. Duvar davranışını etkileyen parametrelerden destek duvarlar varlığı ve duvarda bırakılan boşluklar davranışı oldukça değiştirmektedir. Bu çalışmada tuğla yığma duvarların düzlem dışı davranışları deneysel ve analitik araştırılmıştır. Düzlem dışı konumda bulunan ana duvara dik yerleştirilmiş destek duvarların varlığı ve destek duvarlarda bulunan kapı, pencere boşluklarının ana duvar davranışına etkisi araştırma konusu olmuştur. Bu bağlamda harman tuğlası ile düz örgü türünde tek sıra ile örülmüş ve ½ ile ölçeklenmiş ve eğilme masası yöntemi ile test edilmiştir. Duvarlar tuğla birimleri arasında harç kullanılmadan örülmüş ve 7 farklı numune göz önüne alınmıştır. Destek duvar etkisinin araştırıldığı 4 adet U ve 3 adet L geometrisinde 2 gruba ayrılmıştır. Her duvar modelinde doğru sonuca ulaşmak için 3 adet deney tekrarlanmıştır. Duvarlar Abaqus-2019 programında basitleştirilmiş mikro modelleme tekniği ile sadece sürtünme esaslı modellenmiş ve itme analizleri yapılmıştır. Sonuçlara göre yan duvarların bulunması ana duvar rijitliğini ve yatay yük kapasitesini arttırmıştır. Yan duvarlarda bulunan kapı ve pencere boşlukları hem bulunduğu duvarın hem de ana duvarın rijitliğini düşürmüştür. Boşluk miktarı artışı ile daha erken ve gevrek göçme görülmüştür.
Upaya Meningkatkan Penjualan Produk UMKM Melalui Digital Marketing Di Desa Ngaglik Kec. Srengat Kab. Blitar
Authors: Khusna Sephie Mazidatul , Nasyirudin M. , Rizqia Septian Fadhila
Published: June 2023

Dengan dukungan teknologi informasi, semua urusan jadi lebih mudah. Teknologi tidak bisa dipungkiri telah membawa banyak perubahan dalam dinamika persaingan bisnis saat ini. Mulai dari lahirnya pesaing- pesaing baru, inovasi-inovasi produk baru, sampai hadirnya berbagai model bisnis baru. Dalam pelaksanaan pengabdian Kelompok 24 KKN Universitas Islam Balitar Tahun 2022 menjumpai beberapa UMKM yang mulai merintis usaha. UMKM ini dalam menjalankan bisnis adalah bagaimana menjual barang. Demikian juga dalam kemasan produk hanya sebatas dikemas, tanpa mempertimbangkan aspek design menjadi menarik dan layak jual dalam pasar yang lebih luas. Dengan menggunakan pendekatan survey, wawancara, dan penguatan kapasitas, akhirnya diperoleh hasil: (a) UMKM Jamur Crispy Mak Rin sudah memiliki catatan pendapatan dan juga pengeluaran yang baik. Mereka sudah mulai memahami serta mampu mencatat semua transaksi dengan lancar. Transaksi yang telah dilaksanakan setidaknya telah menjadi bahan pertimbangan bagi UMKM Jamur Crispy Mak Rin untuk memantau biaya produksi dan jangkauan pemasaran; (b) Pelaku UMKM Jamur Crispy Mak Rin mampu mengoperasikan shopee dengan baik, dan mereka kini sudah memiliki beberapa pesanan melalui aplikasi shopee, serta pesanan untuk offline mereka juga semakin meningkat. Bahkan peningkatan sekitar 50-90% dibandingkan dengan sebelum mengikuti pendampingan; (c) Usaha jamur crispy Mak Rin setelah dilakukan fasilitasi deisgn label serta kemasan yang menarik, akhirnya produk mereka semakin dikenal dan setidaknya dalam kurun akhir masa pengabdian, terjadi peningkatan omset penjualan; (d) Setelah dilaksanakan pelatihan dan sosialisasi, para pelaku UMKM merasakan adanya wawasan baru dan motivasi tentang cara menjadikan usaha mereka makin berkembang.
Penggunaan Macro Visual Basic Untuk Penggabungan File dan Pembuatan Ledger
Authors: Bambang Bambang , Lalu Takdir Jumaidi , D. Tialurra Della Nabilla
Published: June 2023

Pengabdian ini bertujuan untuk memperkenalkan penggunaan macro visual basic untuk penggabungan file dan pembuatan ledger Meteode pengabdian terdiri dari 1) Metode ceramah, melalui metode ini peserta diberikan pengetahuan dan pemahaman melalui presentasi oleh pemateri serta motivasi agar memiliki kemauan menerapkan aplikasi. Metode ini dilakukan selama 1/2 jam, 2) Metode tutorial Peserta diberikan panduan langkah-langkah perhitungan PPh 21. Metode ini dilakukan selama 1/2 jam., 3) Sesi praktik, Peserta mempraktikkan langkah-langkah yang telah dipelajari Metode ini dilakukan selama 1 jam, 4) Metode diskusi Peserta diberikan kesempatan untuk mendiskusikan masalah yang dihadapi berkaitan dengan kesulitan dalam dalam perhitungan dan pelaporan. Metode ini dilakukan selama 1 jam. Setelah pelatihan, pegawai telah dapat menggunakan aplikasi untuk penggabungan file dan pembuatan ledger. Tantangan pelatihan adalah masih diperlukan peningkatan mengoperasikan aplikasi excel dan formula-formula tingkat intermediate dan advance, sedangkan untuk pelaporan memerlukan latihan secara berulang dan berkelanjutan.
Peningkatan Kapasitas Pramu Saji Terkait CHSE (Cleanliness, Health, Safety & Environment Sustainability) dan Pelayanan Prima Pada Restaurant di Kawasan Wisata Tanjung Bias Desa Montong Kecamatan Batu Layar, Kabupaten Lombok Barat
Authors: Chaidir Taufiq , Ayu Putri S Ida , Ayu Arini Gst , Ismiwati Baiq
Published: June 2023

Covid-19 yang melanda dunia sejak 2019 berdampak pada semua aspek dalam kehidupan manusia, salah satunya  adalah pada kegiatan pariwisata, hal ini terindikasi dari pola perubahan permintaan wisatawan terhadap : kesadaran kebersihan , kesehatan , keselamatan dan kelestarian  pada destinasi wisatawan termasuk pada restaurant. Oleh karenanya pelaku pariwisata  harus mengetahui dan menerapkan prinsisp yang dikenal dengan CHSE (Cleanliness, Health, Safety & Environment Sustainability)  serta pelayanan prima. Terkait dengan  hal tersebut maka dilakukan pengabdian pada masyarakat pada  pelaku usaha restaurant dan pramu saji yang berada pada destinasi pariwisata Tanjung Bia,  hal ini disebabkan karena berdasarkan hasil observasi 75 % dari pelaku usaha restaurant dan pramu saji belum mengetahui prinsip CHSE dan belum menerapkan pelayanan prima. Metode pelaksanaan pengabdian masyarakat yang  digunakan adalah pertama mengobservasi sasaran target kemudian memberikan materi penyuluhan terkait dengan CHSE serta pelayanan prima dengan menggunakan metode partisipatif serta melakukan evaluasi dan monitoring terhadap hasil kegiatan. Hasil pengabdian menunjukkan bahwa pertama,  peserta tidak mengetahui apa yang dimaksud dengan CHSE dan pelayanan prima.  Hal ini terlihat dari  diskusi yang dilakukan dimana peserta tidak mengetahui bagaimana cara menyajikan makanan dan minuman, tidak mengetahui pentingnya pelayanan prima. Kedua, peserta kurang menyadari pentingnya produk yang sehat, aman proses produksinya serta kurang menyadari pentingnya kelestarian   lingkungan. Namun demikian respon peserta pada kegiatan ini sangat baik,  terlihat dari berbagai pertanyaan yang disampikan dan juga pada saat mereka mempraktekkan cara penyajian makanan  dan minuman  serta peserta bersedia menularkan pengetahuan yang diperolehnya pada pramu saji lainnya diseputar Kawasan Wisata Tanjung Bias.
PERAN KELOMPOK SADAR WISATA (POKDARWIS) DALAM PENGEMBANGAN SEKTOR PARIWISATA DI DESA PAKUAN KECAMATAN NARMADA KABUPATEN LOMBOK BARAT
Authors: Harianti Dewi , Harsono Iwan , Sujadi Sujadi
Published: June 2023

Desa Pakuan dikenal sebagai desa wisata yang kaya akan keindahan alamnya. Pengembangan sektor pariwisata Desa Pakuan tidak terlepas peran Kelompok Sadar Wisata (POKDARWIS). Penelitian ini bertujuan untuk menganalisis peran Kelompok Sadar Wisata (POKDARWIS) dalam pengembangan sektor pariwisata di Desa Pakuan Kecamatan Narmada Kabupaten Lombok Barat. Pendekatan penelitian yang digunakan dalam penelitian ini adalah pendekatan kualitatif dengan metode deskriptif. Teknik pengumpulan data yang digunakan adalah wawancara, observasi dan dokumentasi.Teknik analisis data yang digunakan yaitu analisis data kualitatif deskriptif dan analisis SWOT (Strength, Weakness, Opportunity and Threat). Hasil penelitian ini menunjukkan bahwa Kelompok Sa dar Wisata Desa Pakuan yaitu memperkenalkan dan melestarikan potensi pariwisata yang dimiliki Desa Pakuan, mengelola pariwisata Desa Pakuan, peningkatan pengetahuan dan keterampilan kepada anggota dan masyarakat Desa Pakuan. Berdasarkan hasil Analisis SWOT Pengembangan Sektor Pariwisata Desa Pakuan perhitungan Matriks Grand Strategy menunjukan bahwa titik koordinat perhitungan internal dan ekternal berada pada kuadran I, yang berarti memiliki peluang besar dalam pengembangan sektor Pariwisata.
HAK WARIS ANAK LUAR KAWIN MENURUT KITAB UNDANG-UNDANG HUKUM PERDATA DAN HUKUM ADAT BALI (SUATU TINJAUAN PERBANDINGAN HUKUM)
Authors: Eliana Trisnayani Ni Putu , Sahruddin Sahruddin
Published: June 2023

Penelitian ini bertujuan untuk mengkaji dan menganalisa hak waris anak luar kawin menurut KUH Perdata dengan Hukum Adat Bali dan mengetahui persamaan serta perbedaan hak waris anak luar kawin menurut KUHPerdata dengan Hukum Adat Bali. Penenlitian ini menghasilkan bahwa KUHPerdata menyatakan anak luar kawin yang telah diakui saja yang berhak mendapatkan status keperdatan dari kedua orangtuanya, sedangkan terhadap anak zina dan anak sumbang tidak mendapat ha kwaris. KUHPerdata juga mengatur bagaimana persentase pembagian harta waris bagi anak luar kawin, pengaturan waris bagi anak luar kawin dapat dilihat dalam pasal 863-865 KUHPerdata. Dalam hukuma dat Bali tidak mengakui anak luar kawin sebagai ahli waris dari bapak biologisnya, sehingga hubungan perdata anak lua kawin hanya kepada ibunya saja, tetapi anak luar kawin tetap menjadi tangungan orang tuanya hanya sebatas pemberian lepas (bukan warisan)
PELAKSANAAN PERLINDUNGAN HUKUM BAGI PEKERJA KURIR ATAU PENGANTAR BARANG
Authors: Junaidi Ari , Asyhadie H. Zaeni
Published: June 2023

Penelitian ini bertujuan untuk mengetahui sejauh mana pelaksanaan perlindungan hukum bagi pekerja kurir dan apa saja faktor-faktor yang mempengaruhi pelaksanaan perlindungan hukum bagi pekerja kurir di Ginta Cargo Logistik. Jenis penelitian yang digunakan dalam melakukan penelitian ini adalah jenis penelitian hukum normatif-empiris. Dari hasil penelitian yang telah dilakukan diperoleh hasil penerapan pelaksanaan peraturan terkait waktu kerja, mengaso, cuti, upah dan jaminan sosial tenaga kerja terhadap pekerja kurir di Ginta Cargo Logistik dan terdapat beberapa faktor yang mempengaruhi pelaksanaan perlindungan hukum bagi pekerja kurir baik itu faktor pendukung dan faktor penghambat.
PENGARUH PERENCANAAN PAJAK TERHADAP NILAI PERUSAHAAN DIMODERASI OLEH TRANSPARANSI PERUSAHAAN (STUDI PADA PERUSAHAAN NON-KEUANGAN DI BURSA EFEK INDONESIA)
Authors: Saputra Arya Dwi , Akram  , Sasanti Elin Erlina
Published: June 2023

Penelitian ini bertujuan untuk mengetahui pengaruh perencanaan pajak terhadap nilai perusahaan dengan transparansi sebagai variabel moderasi. Populasi pada penelitian ini adalah perusahaan sektor non-keuangan yang terdaftar di Bursa Efek Indonesia (BEI) tahun 2016 sampai dengan 2018. Sampel ditentukan berdasarkan metode purposive sampling, sehingga diperoleh sebanyak 172 perusahaan sampel. Data yang digunakan dalam penelitian ini berupa data sekunder yang diperoleh melalui situs resmi IDX : www.idx.co.id. Hasil analisis regresi linier menunjukan bahwa (1) Perencanan pajak berpengaruh signifikan terhadap nilai perusahaan, (2) Transparansi dapat mereduksi pengaruh perencanaan pajak terhadap nilai perusahaan. Berdasarkan hasil penelitian tersebut, maka disarankan bagi peneliti selanjutnya agar dapat menambah waktu jangka penelitian dan menambah beberapa variabel dependen untuk mendapatkan hasil yang lebih baik dalam mengidentifikasi variabel lainnya. Penelitian ini mengimplikasikan agar pemangku kepentingan sebaiknya lebih memperhatikan tindakan perencanaan pajak agar tidak memberikan dampak negatif sebagai dasar pengambilan keputusan serta keefektifan peran transparansi dalam laporan tahunan perusahaan.
Growth inhibition and apoptosis induction in two types of women cancer cell lines using laser ablated silver nanoparticles in polyvinylpyrrolidone solution
Authors: ALrawi Nawfal N
Published: June 2023

Silver nanoparticles (AgNPs) coated with polyvinylpyrrolidone (PVP) was prepared by pulsed laser ablation method inPVP solution, 1000 pluse was used with laser energy of 800 mJ/pulse. Formation of AgNPs-PVP was confirmed by UVvisiblespectrophotometer detecting surface plasmon resonance chang in the abilation solution. Concentration of AgNPs, sizedistribution, and surface charge of the ablated AgNPs in the produced solution was determined using atomic absorbtion spectroscopyand zeta potential analysis respectivly. Nanoparticles shape was determined using transmission electron microscopeimaging. Ability of the senthezied AgNPs to inhibit the growth of cancer cells was compared to that of normal fibroblast cellsusing two cancer cell lines (HeLa and SKOV-3) in different concentrations (0.78, 1.56, 3.125, 6.25, 12.5 and 25μg/ml). Theapoptosis events were also detected in both types of cancer cell lines using mitochondrial membrane permeability, nuclearmorphology, and genomic DNA fragmentation. The contribution of AgNPs to the levels of glutathione s-transferase was alsodetermined. According to the results, AgNPs size was 28.43nm with spherical shape and peak UV-Vis absorbance rangedbetween 402-410nm. Concentration of AgNPs in ablated solution was 50μg/ml and used as stock concentration in cell linesexperiments. Ablated silver nanoparticles was capable of inhibit the growth of both HeLa and SKOV-3 cancer cell lines indose and time dependent manner, whereas it was less inhibitory against normal fibroblast cells. All three apoptosis detectionmethod conducted indicated positive characteristics for apoptosis, while GSH levels did not varied significantly in both HeLaand SKOV-3 cells.Keywords: AgNPs, cancer cells, metal silver, Cytotoxicity, MTP, DNA fragmentation, GSH.
Pathological study on some common bone tumors in human
Authors: Aljeboori1 Khalil H.
Published: June 2023

The study aimed to find the most common bone tumors , affected ages and to identify gross and microscopical appearances. Thirty bone tumor were obtained ; 28 cases diagnosed as primary bone tumor and 2 cases diagnosed as secondary bonetumors . The primary benign bone tumors (13) while malignant bone tumor (11) and the rest (4) cases were tumor like conditions.The primary bone tumors are diagnosed as follows osteoid osteosarcoma (4),osteoma(2),chondroblastoma(1),osteochondroma(6)chondrasarcoma (2), fibrosrcoma (1) , giant cell tumors (5) , hemangiosarcoma (1) , ewing sarcoma (1) , lymphoma (1). aneurysmal bone cysts (3) and fibrous dysplasia (1) . The secondary bone tumors (2) metastatic bronchial carcinoma case andanother case poorly differentiated prostatic carcimomaConclusion: Osteosarcoma is the most common malignant primary bone tumors and osteochondroma is the most commonbenign primay bone tumor .key word: pathology of some bone tumors in human patients
Growth inhibition of mice mammary carcinoma cell line with green synthesized Magnetic Iron Oxide Nanoparticles
Authors: Tawfeeq Amer T.
Published: June 2023

Mammary adenocarcinoma represents one of the most cancers that effect woman in Iraq and worldwide. Finding a definitecure for this type of cancer is a target of considerable research in many laboratories over the globe. In this study, a greensynthesized magnetic iron oxide nanoparticles (MNP) was used to specify their ability to inhibit the growth of mice mammarycarcinoma cell line (AMN3), it comes as a preliminary study of wider ongoing research. After successfully synthesizing magneticiron nanoparticles, it employed in different concentrations to expose AMN3 cells for 24 and 48 hours. The viability of theexposed cells was determined using standard MTT assay. The inhibition concentration 50 was determined afterward and usedto test the possibility of inducing apoptosis in the carcinoma cells using a mixture of fluorescent stains acridine orange andpropidium iodide. Results indicated that green synthesized MNP can inhibit the growth of mammary adenocarcinoma cell lineup to 79% and 89% after 24 and 48 hr of incubation with 1000μg/ml. The IC50 of MNP was capable of inducing apoptosis inthis cell line as shown by fluorescence microscope. The standard hemolysis assay used to test the reaction between the greensynthesized magnetic oxide nanoparticles and normal cells. The IC50 of AMN3 cells growth inhibition only induce 14% ofRBC hemolysis, while the percentage induced by negative control was 10%. In conclusion, green MNP have an effect uponcancer cells greater than normal cells. This material must tested against other types of cancer and normal cells to verify itsaction and study mechanisms of apoptosis induction in detail.Key words: Magnetic iron oxide nanoparticles, AMN3, green synthesis, nanotherapy.
Analisis Kadar Timbal (Pb) Dan Serum Glutamic Pyruvic Transaminase (SGPT) Pada Pengemudi Ojek Online Di Kota Denpasar, Bali
Authors: Yuan Rahayu Artini , Aryasa I Wayan Tanjung , Cahyaningrum Putu Lakustini
Published: June 2023

motorcycle taxi is a transportation service with communication technology in the world. The average mobility of online motorcycle taxi drivers is between 8-12 hours per day, this will certainly affect the physical condition and function of the drivers' organs, especially motorbike drivers. The purpose of this study was to determine the health status of online motorcycle taxi drivers, which was reviewed from liver function tests, namely serum glutamic pyruvic transaminase (SGPT) and exposure to heavy metal lead (Pb). This study used an experimental experimental research design pretest-posttest control group design. In this study, there was an increase in the levels of SPGPT and lead (Pb) for online motorcycle taxi drivers in Denpasar City with the SGPT level for male drivers being 14.14% and for women 19.62% and lead (Pb) levels for male drivers. -Male is 2.61% and female 5.14%.
The Potential of Averrhoa bilimbi Juice As An Alternative Reagent in Proteinuria Examination
Authors: Kristinawati Erna , Nur Nutri Farda , Hasanah Idyatul
Published: June 2023

Background: Proteinuria indicates a kidney disorder and provides important prognostic information in diagnosing kidney disease. To determine the presence of protein in the urine, a urinalysis examination is carried out.  Proteinuria examination generally uses the heating method with acetic acid, sulfosalicylic acid, and concentrated nitric acid as reagents. In Indonesia, the use of acetic acid for proteinuria examination is still the primary choice. An alternative reagent is needed that can replace the function of acetic acid. The objective of this study is to determine the potential of Averrhoa Blimbi juice as an alternative reagent for proteinuria examination.Methods: This was a Pre-experimental study with a completely randomized design. This study used urine samples from a patient with chronic kidney disease. Urine samples were examined using 6% acetic acid reagent as a control and using Averrhoa bilimbi juice with various concentrations. Each juice concentration was examined twice so that the experimental units in this study were 40 units. The Kruskal-Wallis test was used to determine the potential of Averrhoa bilimbi  as an alternative reagent.Results: At concentrations of 5%-20% showed the same positive results as 6% acetic acid, namely +2, concentration 25%-35% resulted in +3, and other concentration resulted in +4. The results of data analysis showed p=0.04 (p<0.05). This shows that Averrhoa bilimbi has the potential as an alternative reagent for proteinuria examination.Conclusion: Averrhoa bilimbi  juice with a 5%-20% concentration has the potential as an alternative reagent for 6% acetic acid to check proteinuria levels.Keywords: Averrhoa bilimbi ; alternative reagents; proteinuria; acetic acid; urinalysis