bluuebunny/crossref_metadata_2025 huggingface dataset:
SENGKETA BHUTAN-TIONGKOK-INDIA: KONFLIK DOKLAM
Authors: Emmanuela Josephine , Arianti Chika , Kusuma Arya , Tobing Mika , Yehezkiel Chaterine
Published: December 2019

Sengketa antara Tiongkok-Bhutan atas wilayah Doklam mengakibatkan instabilitas kemanan di wilayah tersebut. Bhutan yang kemudian meminta bantuan India untuk mengatasi sengketa di Doklam menambah konstelasi baru dalam krisis sengketa yang ada Doklam. Penelitian ini bertujuan untuk menjelaskan bagaimana upaya penyelesaian konflik Doklam antara Tiongkok-India. Dalam penelitian ini akan dijelaskan bagaimana proses terjadinya sengketa yang ada di Doklam, dan proses perdamaiannya. Diskusi kemudian berlanjut kepada, One China Policy yang melatar belakangi Tiongkok dalam melakukan sengketa terhadap wilayah Doklam. Untuk menganalisis kasus sengketa Doklam, penulis menggunakan teori â€œRealismeâ€. Untuk mendukung penelitian ini, penulis menggunakan metode kulitatif.

 

Kata Kunci : Tiongkok, India, Sengketa, Doklam, Bhutan
Kent Parklarda Kullanılan Donatıların Standartlara Uygunluğunun Belirlenmesi: Ankara Örneği
Authors: ÖNAL Sibel
Published: December 2019

Kentsel donatılar kullanıcılar için kenti yaşanabilir ve algılanabilir hale getirmektedir. Donatılar kentlere olduğu gibi parklara da kimlik kazandırmaktadır, bu nedenle donatıların bir süreklilik göstermesi ve parkın kimliğiyle uyumlu olması gereklidir. Araştırmanın konusunu Ankara’da yer alan Altınpark, Gençlik Parkı, Göksu Parkı ve Seğmenler Parkı oluşturmaktadır. Araştırmanın amaçlarından biri, Ankara’daki kent parklarında kullanılan oturma birimleri, çöp kutuları ve aydınlatma elemanlarının TSE standartlarına uygunluğunun belirlenmesidir. Çalışmada kullanıcıların da donatılarla ilgili görüşlerinin alınması için 1091 (533 erkek ve 558 kadın) kullanıcıya kullanıcı memnuniyeti anketi uygulanmıştır. Araştırma sonucunda parklarda kullanılan aydınlatmaların tümünün standarda uygun olduğu ancak oturma birimlerinin bazılarının ve çöp kutularının çoğunluğunun standartları karşılayamadığı saptanmıştır. Anket sonuçlarına göre kullanıcıların oturma birimlerini sayı olarak yetersiz buldukları, Seğmenler Parkı dışında çöp kutularını sayı olarak yeterli buldukları belirlenmiştir. Parkların tümünde aydınlatmayı yeterli bulan kullanıcılar aynı zamanda parklarda kendilerini güvende hissetmektedirler. Yapılacak olan çok disiplinli bir araştırma ile donatıların tasarımında kullanılacak olan antropometrik veri tabanının oluşturulmasının önem arz ettiği kanısındayız. Böylece kentsel donatılar, okul sıraları, ofis mobilyaları gibi yaşamın her alanında kullanılan eşyaların tasarımı için ülkemize ait standartlar belirlenebilecektir.
Comparison of effectiveness of manual and automatic processing of endoscope
Authors: Dubel E. V. , Sheprinsky P. E.
Published: December 2019

Through rapid ATP tests, it was found that additional automatic cleaning of endoscopes after manual handling reduces the number of cases of inadequate final cleaning of the surface of the endoscope and its channels by 4.0–4.5 times as compared to using manual treatment alone. Performing of an automatic final cleaning of endoscopes enables to increase the degree of epidemiological safety of non-sterile endoscopic interventions.
Significance of lipid peroxidation disorders in genesis of neurological disorders after carotid endarterectomy
Authors: Shadymov B. A. , Neimark M. I. , Shmelyov V. V. , Shaidurov A. A.
Published: December 2019

The article considers the question of the appropriateness of the use of the drug based on succinic acid in the surgical treatment of atherosclerotic occlusion of the carotid artery, for the prevention of neurological complications in the postoperative period. A comparative characteristic of the obtained data of oxidative, antioxidant statuses, as well as markers of neuronal damage in two groups was carried out. The results suggest that the use of cytoflavin during the stages of surgical treatment reduces the number of neurological disorders.
Is there any connection between method of priming extracorporeal circuit and cerebral oximetry results?
Authors: Basylev V. V. , Evdokimov M. E. , Pantyuhina M. A. , Kokushkin M. V.
Published: December 2019

Objectives.To compare the influence of different priming techniques on cerebral oximetry results during CPB in adult patients.

Methods.This study is a single-center retrospective review of data collected from adult patients who underwent isolated CABG with CPB between January and December, 2016. The patients were divided into two standardized groups with the sole difference between them being the method of priming CPB circuit: the first one was the group where we used our modified retrograde method of priming (n = 45) and the second one was the group with standard priming (n = 45). Hematocrit, hemoglobin, cerebral oxygenation were evaluated at the following points: beginning of the operation, start of CPB, cross clamping, 15, 30, 45 minutes and the end of CPB and the end of operation.

Results.In the first group indices of cerebral oximetry were higher comparing to the second group at list of the 45 minutes of CPB (р < 0,001). For the first 15 minutes of CPB hematocrit was also higher in the first group. Priming volume and the need for blood transfusion or ultrafiltration were also smaller in the first group.

Conclusion.Modified priming technique allows to maintain higher indices of cerebral oximetry, decreases volume overload and the need for blood transfusion comparing to standard technique.
Protection of upper respiratory tract of patient in conditions of respiratory support: current state of issue
Authors: Vlasenko A. V. , Koryakin A. G. , Evdokimov E. A. , Eryomin D. A.
Published: December 2019

Acute respiratory failure has been and remains one of the main problems of modern medicine. Among the large number of high-tech methods of treating acute respiratory failure, adequate moisture and warming of the upper respiratory tract of the patient at all stages of the respiratory therapy are important. It should be noted that ensuring optimal moistening and warming of the inhaled gas mixture allows to avoid the development of many pulmonary complications. On the other hand, even with the use of the most modern treatment methods, inadequate microclimate in the upper respiratory tract can significantly reduce the effectiveness of their use. Thus, maintaining an adequate microclimate in the upper airways is normal, with various bronchopulmonary diseases and in conditions of respiratory support will improve the functional state of the lungs, prevent the development of many complications, reduce material costs and duration of treatment, reduce the mortality of this patient population. Despite the existence of the large database, the question of choosing the most effective technology to ensure homeostasis and protection of the upper respiratory tract in different clinical situations with different methods of respiratory support is still relevant. This dictates the necessity of continuing the research in this direction. This review is devoted to the current state of the problem of moistening, warming and filtering the breathing mix under conditions of prosthetic respiratory function.
Effect of endogenous bacteriophages on results of treatment of pyo-inflammatory complications in resuscitation patients
Authors: Lazareva E. B. , Chernenkaya T. V. , Shabanov A. K. , Evdokimova N. V. , Zhilenkov E. L. , Godkov M. A. , Petrikov S. S.
Published: December 2019

The article is devoted to the study of the effect of own endogenous bacteriophages on the course and outcomes of severe concominant injury. The microflora isolated from the blood of resuscitation patients was analyzed. The mortality rate and the presence or absence of endogenous bacteriophages were compared. Less lethal outcomes were found in patients with endogenous bacteriophages, regardless of whether they are virulent or moderate. In the absence of endogenous bacteriophages, K. pneumonia and staphylococci were isolated from the blood of patients with further lethal outcome more often than other species.
Analysis of results of daily blood pressure monitoring in patients with hypertension
Authors: Lityushkina M. I. , Malkina N. V.
Published: December 2019

In this work we represented the results of the dynamics of blood pressure of 62 patients with coronary artery disease combined with hypertension according to blood pressure monitoring. It was found that 40.0 % of them with a high variability and 52.5 % have insufficient night decrease in arterial pressure (non-dipper). Most of the article is devoted to the analysis of the main indicators of BPM depending on the age and sex of the patients.
Role of physiotherapeutic factors in improving peripheral hemodynamics in patients with rheumatoid arthritis
Authors: Koshukova G. N.
Published: December 2019

130 rheumatoid arthritiS patients (RA pts) were distributed in the comparative groups on the basis of used physiotherapy methods and placebo‑physiotherapy. Violation of peripheral blood‑flow mainly vessels of small and medium caliber mainly vessels of small and medium caliber in RA pts in comparison with group of practically healthy persons at baseline was detected, the severity of these abnormalities depended on duration of disease. The comparative analysis of basic rheovasographic indexes in RA pts before and after treatment in parallel groups treated with electrosleep‑therapy, low‑frequency magnetotherapy, bioresonant stimulation and placebo‑physiotherapy was conducted. Significant differences in studied indexes after completed course of treatment such as diminishing of asymmetry of blood‑filling in extremities at all types of physiotherapy, increasing of pulse vascular blood‑filling of extremities after electrosleep‑therapy and bioresonant stimulation, decrease of vascular tonus after application of low‑frequency magnetotherapy were defined. Course of placebo‑physiotherapy has not demonstrated statistically meaningful changes in rheovasographic indexes. Clinically significant adverse events during physiotherapy treatment were not detected. Conclusion: including of physiotherapy in the management of RA pts in term to improve peripheral hemodynamics and to prevent vascular complications can be recommended.
Experience in use of collagen-based drugs in complex treatment of recurrent aphthous stomatitis
Authors: Uspenskaya O. A. , Tiunova N. V. , Timoshenko A. D. , Alekseeva S. M. , Shamro A. A.
Published: December 2019

Recurrent aphthous stomatitis is characterized by a recurrent course, torpidity to conventional therapy and painful ulcerations. Despite the continual improvement of the diagnostic methods and treatment of the disease, the incidence of RAS tends to increase. So, the search for new drugs and the treatment of this pathology is important and justified. The article presents the case of complex treatment of recurrent aphthous stomatitis, using collagen biodegradable drugs in the local treatment regimen, which showed the good clinical result.
Prevention of complications of intestinal J pouch reservoir
Authors: Atroschenko A. O. , Danilov M. A. , Abdulatipova Z. M. , Pozdnyakov S. V. , Dolgopyatov I. A. , Teterin A. V. , Chudnikh S. M. , Mikhaylyants G. S.
Published: December 2019

The first colproctrectomy with the formation of a pelvic intestinal reservoir was performed in 1970. Since then, the technique has been thoroughly tested and currently it is the gold standard in the surgical treatment of ulcerative colitis and familial adenomatous polyposis. This operation allows to improve the quality of patients’ life, reducing the need to form a permanent ileostomy, improving the psychomotional, social and physical rehabilitation of patients. However, this intervention is associated with a high risk of postoperative complications. Impairment of the the pelvic reservoir functioning, as well as the addition of infection, are terrible complications that significantly worsen the patient’s quality of life. Surgeons performing this type of surgery have to face a number of intraoperative and postoperative complications that require repeated interventions. The aim of the study is to improve the results of treatment of patients with the small bowel reservoir. A review and analysis of the literature is performed in this issue. Successful results of performing colproctectomy with the formation of a pelvic enteric reservoir depend on careful preoperative planning, experience of the surgeon, prevention of intra‑ and postoperative complications.
Structural features of pancreas in patients with various clinical and morphological forms of chronic pancreatitis
Authors: Gubergrits N. B. , Krylova E. A. , Gravirovskaya N. G.
Published: December 2019

The article is devoted to the results of our own research into the possibilities of ultrasound diagnostics of various clinical and morphological forms of chronic pancreatitis (CP). It was shown that pronounced structural changes in the pancreas (pseudocysts, calcinates, wirsungolithiasis, pronounced fibrosis) make it possible to diagnose clinical and morphological forms of CP.
Relationship between food allergies and composition of intestinal microbiota at irritable bowel syndrome
Authors: Turchina M. S. , Korolyova L. Yu. , Bukreeva M. V. , Erofeeva E. A. , Borzova D. V.
Published: December 2019

Currently, there is an increase in the number of patients with irritable bowel syndrome (IBS). However, to date, there is no single concept of the etiopathogenesis of functional disorders of the digestive tract. Initially, great attention was paid to disorders of motility and impaired regulatory interactions of the brain‑intestine as causes of irritable bowel syndrome, but in recent years the focus has shifted to subclinical inflammation in the colon mucosa and the development of visceral hypersensitivity. The reasons contributing to the formation of immune inflammation in the intestinal wall, include a violation of the composition of the intestinal microbiota, as well as food allergies and food intolerance. This article discusses the qualitative and quantitative changes in the intestinal microbiota in patients with irritable bowel syndrome if they have food allergies, as well as the effect of the composition of the intestinal microbiota on the clinical variant of irritable bowel syndrome. The study included 257 patients with IBS. At the first stage, an assessment was made of the history of food allergies, such as IBS, in accordance with the Bristol scale, as well as a microbiological study of feces. At the second stage, the evaluation of intestinal microbiota correction schemes was carried out in patients who had food allergies. The patients were divided into two equal groups, the first group received intestinal antiseptic in combination with multi‑component probiotic, the second — intestinal antiseptic in combination with Saccharomyces boulardii. When analyzing the obtained results, it was noted that approximately half of patients with IBS in the anamnesis had manifestations of food allergy. In most cases, food allergy was associated with the development of patients with IBS variant with diarrhea and excessive growth of conditionally pathogenic microflora with a decrease in the number of lactic and bifidobacteria. When comparing schemes for the correction of disorders of the intestinal microbiota, the greatest efficacy was observed with the combination of intestinal antiseptic and Saccharomyces boulardii.
Fetal programming
Authors: Sandakova E. A. , Zhukovskaya I. G.
Published: December 2019

The concept of fetal programming implies the influence of factors of the external and internal environment in the intrauterine period on the epigenetic regulation of the genome, which leads to phenotypic changes in the fetus, as well as to postnatal diseases of man, manifesting throughout life. It is possible to improve the state of health, quality and life expectancy of offspring, as well as subsequent generations, due to the pregravidar preparation of both parents, the modification of their lifestyle, the abandonment of bad habits, the rationalization of nutrition, and the donation of vitamin and mineral complexes.
Optimization of treatment of recurrent vulvovaginal candidiasis
Authors: Tkachenko L. V. , Sviridova N. I. , Bogatyryova L. N. , Gritsenko I. A.
Published: December 2019

The purposeof the study was to evaluate the efficacy of treatment of recurrent drug Orungamin depending on the time of occurrence of relapse.

Material and methods.62 women with recurrent candida vulvovaginit is were examined and treated. The mean age of the patients was 35.6 ± 0.7 years. The main group consisted of 32 patients who in the premenstrual period 5 days before the expected date of menstruation were prescribed Orungamin 1 capsule (100 mg) twice a day (200 mg) for 3 days during three consecutive menstrual cycles. The comparison group included women receiving Orungamin three consecutive cycle 3 day 1 capsule (100 mg) 2 times a day, without regard to days of the menstrual cycle.

Results.Therapy with Orungamin 100 mg twice a day during the premenstrual period not only helped to increase the effectiveness of the treatment of relapses, but also the quality of life of patients.
Use of drugs of medicinal herbs for insomnia treatment
Authors: Korabelnikova E. A. , Danilov Al. B.
Published: December 2019

Therapy with medicinal herbs in the complex of therapeutic actions for insomnia occupies a special place. The main advantage of phytotherapy of sleep disorders is their high therapeutic efficacy in the absence of side effects, except in cases of individual sensitivity to individual components of the drug. Unlike synthetic drugs, drugs, which are based on vegetable raw materials, have a rapid effect on the extracellular and intracellular metabolic processes. Therefore, the therapeutic effect of medicinal plants is persistent and prolonged. The method of phytotherapy is an alternative and highly effective method of treatment of insomnia, and it should not reject, but significantly complement other methods of modern medicine.
Mental status of patients in cosmetology as predictor of satisfaction with aesthetic procedures and psychometric scales for its assessment (literature review)
Authors: Shakhnovich A. A. , Ragimova A. A. , Samushiya M. A. , Efremov A. A.
Published: December 2019

In this literature review we describe factors affecting satisfaction with the quality of cosmetic procedures. We also discuss psychometric scales used in world practice of aesthetic medicine and cosmetology to identify comorbid mental pathology that determines dissatisfaction with the results of medical interventions.
Actual recommendations for multicomponent drug use in dermatology
Authors: Kruglova L. S. , Fyodorov D. V. , Stenko A. G. , Gryazeva N. V. , Yakovlev A. B.
Published: December 2019

Many years of experience in using fixed combinations of topical glucocorticosteroids in dermatology today seem to be justified not only theoretically (the pathogenesis of immuno-inflammatory and infectious dermatoses), but also from the perspective of optimizing therapeutic measures in this category of patients. From this position, the innovative combination drug Tetraderm® can be regarded as the drug of choice for dermatoses of combined etiology. The composition of the drug includes highly effective components that allow you to affect the inflammatory component, infection and trophic tissue in the lesions. The components of the drug show a favorable profile of antibacterial and antimycotic activity. Highly potent corticosteroid can effectively stop inflammation. The drug has prospects for use in various dermatoses of combined etiology (atopic dermatitis, eczema), in clinical situations when mycoses or pyoderma have signs of eczematization of the process, rashes in large folds, cystic dermatoses and diskeratoses.
Bisoprolol in treatment of arterial hypertension in pregnant women
Authors: Stryuk R. I.
Published: December 2019

Summary In pregnant women with different clinical options for arterial hypertension, highly selective beta-blockers may be the drugs of choice from the second trimester of pregnancy. The drugs of this group according to the FDA (US Food and Drug Administration) are classified as category C. Their purpose corresponds to the principle of risks and benefits. One of the highly effective and safe drugs in this group is bisoprolol. However, for early detection of the possible negative effects of beta-blockers on the fetus (a newborn), the probability of occurrence of which is extremely low, it is advisable to monitor the vital functions of the fetus (a newborn), the level of glycemia.
Influence of amiodarone on spectral analysis of heart rate variability in patients with atrial fibrillation (clinical observation)
Authors: Popova E. P. , Bogova O. T. , Puzin S. N. , Sychyov D. A. , Fisenko V. P.
Published: December 2019

Spectral analysis of heart rate variability can be successfully used to evaluate the effectiveness of therapy. The use of this method gives an idea of the role of the autonomic nervous system in the regulation of chronotropic function of the heart. These data help to define conditions of manifestation of efficiency of antiarrhythmic drugs. In this study, spectral analysis were studied in patients with persistent atrial fibrillation. The effect of amiodarone class III antiarrhythmic drug were studied this study.
Frequency and nature of complications associated with drug and electric cardioversion in patients with atrial fibrillation in hypertension in combination with extracardial comorbid pathology and adherence to treatment
Authors: Khidirova L. D. , Yakhontov D. A.
Published: December 2019

Aim. To evaluate the complex of antiarrhythmic therapy and adherence to treatment on an outpatient basis in patients with atrial fibrillation in hypertension in combination with extracardiac diseases.

Methods. In an observational cohort study, 308 men aged 45–60 years old were observed with atrial fibrillation and hypertension in combination with diabetes mellitus (n = 40), diffuse toxic goiter (n = 42), hypothyroidism (n = 59), abdominal obesity (n = 64) and chronic obstructive pulmonary disease (n = 47). The comparison group consisted of 56 patients without extracardiac pathology. The work evaluated clinical, anthropometric data, the results of daily monitoring of ECG and echocardiography. Adherence to therapy was evaluated using a specialized Moriski-Green questionnaire.

Results. Patients with diabetes mellitus on the background of electric cardioversion significantly more often developed CHF (p = 0.003), cardioembolism (p < 0.001), hospitalization (p = 0.040) and progression of AF (p < 0.050), relative to the comparison group. The number of regospitalizations was noted less after electrical cardioversion compared with only medical one. The adherence to drug therapy in patients with atrial fibrillation in hypertension with extracardiac disease was 26.7 %.

Conclusion. The reasons for the lack of patient adherence to treatment require an integrated approach to its early resolution.
Dynamic ultrasound examination of intestinal failure syndrome in patients with severe combined trauma
Authors: Ermolov A. S. , Alekseechkina O. A. , Vladimirova E. S. , Shakotko A. P.
Published: December 2019

Objective: to identify ultrasound (US) signs of intestinal failure syndrome (IFS) in patients with combined trauma and to determine their compliance with the clinical classification of IFS. In the process of dynamic ultrasound monitoring in 18 patients on the 5–7th day, gastrointestinal motility recovered with a decrease in intra-abdominal pressure (IAP) to normal, which corresponded to stage I of IIS. In 12 patients, gastrostasis and expansion of the small intestine, an increase in the linear blood flow velocity in the portal vein up to 30 cm/sec, IAP up to 20 mm Hg were observed which corresponded to stage II of IFS. On the 15–20th day, 3 patients with stage III of IFS recovered gastrointestinal motility, 9 patients died due to multiple organ failure. Ultrasound revealed an increase in the liver and spleen with portal hypertension, edema of the walls of the small and large intestines was observed, intra-abdominal pressure increased, which corresponded to stage III of intestinal failure.

Results. The results of ultrasound in dynamics with an assessment of the morphological and functional state of the gastrointestinal tract confirm their compliance with the stages of the clinical classification of intestinal failure syndrome. With the help of ultrasound with dopplerography and measurement of IAP, it was possible to objectify the clinical classification of intestinal failure syndrome.
First experience with xenon in treatment of severe trauma in children
Authors: Sabinina T. S. , Bagaev V. G. , Amcheslavsky V. G. , Bagaev Yu. V. , Bykov M. V. , Averyanov S. N. , Novikova T. S. , Raushenbakh N. G.
Published: December 2019

Introduction.The authors discuss their first experience of applying the inert gas xenon (Xe) for relieving a persistent pain syndrome (PPS) and acute stress disorders (ASD) in children with severe injuries.

Material and methods.Seven children with severe trauma were taken into the trial: the five with severe combined trauma after a terroristic attack (Kerch, 2018) and the two with multiple dog bites. All victims had PPS and ASD after the survived fear of death. Xenon had 15–30 % concentration in oxygen . Xe-therapy lasted for 15–20 minutes.

Results.During Xe-sessions, patients were sedated. BIS-index decreased from 95.5 ± 2.5 to 86.5 ± 5.0 U (p < 0.05); mean values by Ramsay scale decreased from 5.5 ± 0.5 to 2.7 ± 1.2 scores (p < 0.05). Pain intensity by Numeric Rating Scale for Pain decreased from 4.1 ± 1.8 to 1.1 ± 0.4 scores (p < 0.05). Five sessions were needed for controlling PPS and refusing of analgesics; 12 session for phantom pains; 3 sessions for sleeplessness; 5 sessions for erasing tragic events from the memory.

Conclusion.15–30 % Xe inhalations were effective in controlling PPS and ASD in children with severe injuries.
Genetic predisposition and resistance to certain infectious diseases. I. AIDS
Authors: Shcherbo S. N. , Shcherbo D. S. , Tishchenko A. L. , Savina M. I. , Turkina T. I.
Published: December 2019

The review addresses issues related to genetic predisposition and resistance to infectious diseases. Genetic factors largely determine the susceptibility of the body to various diseases, including infectious ones. A genetic predisposition to tuberculosis, salmonellosis, viral hepatitis, tick-borne encephalitis, Lyme disease, HIV and others is shown. Knowledge of molecular genetic biomarkers is necessary for identifying risk groups, conducting predictive measures, in particular vaccination. The main influence is given to the genes of the main histocompatibility complex; the role of mitochondrial DNA in susceptibility to HIV infection is shown.
Role of molecular genetic non-invasive laboratory diagnostics in prevention of RH-conflict pregnancy
Authors: Khabarov S. V. , Denisova O. V. , Devichensky V. M.
Published: December 2019

The review is devoted to the possibility of non-invasive prenatal determination of the RH-factor of the fetus in early pregnancy based on the analysis of fetal DNA circulating in the peripheral blood of a pregnant woman. Methodical approaches to the isolation and analysis of extracellular fetal DNA are considered. The assessment of medical and economic efficiency of prenatal noninvasive screening of RH-factor of the fetus in RH-negative pregnant women is given. The possibilities, limitations and prospects of using molecular genetic non-invasive laboratory methods to determine the RH-factor of the fetus are discussed.
Application of barrier membranes made of acellular collagen matrix for alveolar ridge reconstruction with guided tissue regeneration method
Authors: Neizberg D. M. , Silina E. S. , Pachkoria M. G.
Published: December 2019

The guided tissue regeneration (GTR) is one of the basic ways for alveolar ridge reconstruction in the implantology and periodontology. It has been using for more than 30 years and allows to get stable and predictable outcomes. However, quality and volume obtained tissues depends on a wide range the local, systemic and technological features which have to be taken into account. Only this approach let us achieve predictable and stable outcomes of the therapy. In the article two clinical cases of GTR are depicted in two different applications of the dermal matrix Collost usage as a collagen barrier membrane.
Use of adhesive cream ‘Aphtofix’ for oral mucosa in dentistry
Authors: Fomenko E. V. , Grudyanov A. I.
Published: December 2019

The article discusses the effectiveness of the use of the adhesive agent Aftofiks in the complex treatment of diseases of the oral mucosa. The positive effect of Aftofix adhesive on the timing of epithelization of wound surfaces of the oral mucosa, pain reduction, ease of application of the drug and its safety have been studied.
Features of treatment of non-motor disorders in Parkinson's disease: role of Selang in correction of emothional disorder
Authors: Safonova N. Yu. , Lukina L. V.
Published: December 2019

The article reflects the main features of non-motor manifestations in Parkinson's disease. Emotional-affective disorders (anxiety, depression), cognitive impairment are described. The possibilities of drug correction of non-motor disorders in Parkinson's disease are analyzed.
Characteristics of emotional state and cognitive processes in patients with ischemic stroke in acute period
Authors: Kotsyubinskaya Yu. V. , Kazakov A. V. , Safonova N. Yu.
Published: December 2019

Currently, studies aimed at assessing the emotional state and cognitive processes associated with the processing of emotionally determined information in patients with ischemic stroke, as well as finding the relationship between them are particularly relevant, mainly for the subsequent optimization of the therapeutic process. In order to identify the features of the emotional state and cognitive processes, a group of patients with ischemic stroke in the acute period in the amount of 25 people was examined. It was established that in patients with a lesion in the anterior cortex, depressive states in the acute period of stroke are more pronounced. Patients successfully reproduce emotionally significant words in comparison with neutral words; an interrelation between the level of anxiety and depression was found, which indicates that these states are comorbid. But, in turn, the relationship of the severity of anxiety and depression with the cognitive processes of recognition and reproduction, as well as differences in mnestic and gnostic activity in patients with different levels of anxiety and depression were not identified. After the treatment with Semax an improvement was noted.
Chronic headache treatment: can we always follow international guidelines?
Authors: Latysheva N. V.
Published: December 2019

International guidelines on the prevention of migraine recommend the use of five main classes of medications: beta-blockers, antiepileptics, antidepressants (amitriptyline and venlafaxine), angiotensin receptor antagonists and botulinum toxin type A. Chronic tension-type headache (CTTH) guidelines are even more limiting and contain only amitriptyline, venlafaxine and mirtazapine. However, long-term intake of these medications is substantially limited by their tolerability issues. Moreover, most recommended medications cannot control the most frequently observed comorbidities, where depression plays the most important role in treatment selection, efficacy and long-term prognosis. This paper reviews the current migraine and CTTH prevention guidelines and complexities that physicians encounter with their use. The paper also includes a case series of treating chronic headache with a new multimodal antidepressant vortioxetine.
Alternative approach to evaluation of efficiency of medicamental abortion in early stages
Authors: Dikke G. B. , Astapova M. K. , Uzdenova Z. Kh. , Shcherbatykh E. Yu.
Published: December 2019

Objective.To determine the effectiveness of alternative methods for assessing abortion using the drug method at an early date for use in the interests of patients.

The main provisions.35 literary sources published in the MEDLINE, PubMed, and other databases were analyzed. It has been shown that the woman’s independent use of semi-quantitative or multi-level tests for determining the content of β-hCG in the urine at home, combined with telephone control by a physician, has high sensitivity and specificity in diagnosing pregnancy termination, is not inferior in terms of the effectiveness of ultrasound, and excludes the likelihood of overdiagnosis of abortion.

Conclusion.Routine clinical examination and ultrasonography are not required after medical abortion, and self-testing for β-hCG in the urine can be used to confirm the complete termination of pregnancy in the early stages.
Diagnosis and therapy of mixed and recurrent vulvovaginal infections
Authors: Kuznetsova I. V.
Published: December 2019

Infections of the vulva and vagina remain one of the most pressing problems of modern gynecology due to the high prevalence, frequent relapses, and negative effects on the functions of the reproductive system, which increases the risks of gynecological diseases and obstetric complications. The most common forms of vulvovaginal infection are bacterial vaginosis (BV), vulvovaginal candidiasis (VVC), aerobic vaginitis (AB) and trichomoniasis. Features of the biocenosis and immune status in infections caused by conditionally pathogenic microorganisms predispose to relapses of BV, AB, and VVK, against the background of which a mixed infection develops. Its occurrence is also the result of repeated courses of treatment for recurrent monoinfection. Therapy of BV consists in the use of metronidazole and clindamycin, the benefits of clindamycin are in a wider spectrum of action, covering difficult to identify anaerobic microorganisms, as well as aerobes. The treatment of mixed infection and the prevention of the development of IHC in patients with BV involves the use of azole antimycotics, which remain the first line treatment option for the infection caused by Candida albicans. Thus, the combination therapy with clindamycin and azole antimycotics can be considered the optimal treatment option for mixed and recurrent vulvovaginal infections.
Prophylaxis of placental insufficiency and other complications of gestation in women with diseases associated with endothelial dysfunction
Authors: Dikke G. B. , Pustotina O. A. , Ostromensky V. V.
Published: December 2019

The pathogenesis of placental insufficiency and other complications of gestation is associated with vascular endothelial dysfunction. Glycocalyx covering the endothelium plays a fundamental role in coagulation and fibrinolysis. The presence of low molecular weight glycosaminoglycans in glycocalyx has a protective effect. The proven clinical efficacy of sulodexide to correct vascular endothelial dysfunction, prevent placental insufficiency and other pregnancy complications makes it a promising tool for use in obstetric practice among patients with chronic diseases (arterial hypertension, diabetes, obesity, etc.), autoimmune pathology, thrombophilia and related pregnancy complications (gestational diabetes, hypertension in pregnant women, pre-eclampsia, recurrent miscarriage, fetal growth retardation).
Transition period of estrogen-progestogen hormone therapy
Authors: Kuznetsova I. V.
Published: December 2019

Combined hormonal contraception is an effective method of preventing pregnancy and at the same time has a number of therapeutic effects. The need for contraception persists until the final cessation of menstrual function, but at an older fertile age, the selection of a hormonal agent becomes a daunting task. Over the past years, a woman has accumulated factors that can complicate the use of hormonal drugs, and, on the other hand, new problems arise in the transitional period of life, which combined contraceptives can solve. An equally relevant topic is the question of stopping the use of combined hormonal contraceptives and initiating menopausal hormone therapy. All of the above aspects of the use of hormonal drugs require deep understanding for the adequate management of women entering the final phase of reproductive life.
Political and military lessons of the Russian campaign in Syria
Authors: Volovoj Vadim
Published: December 2019

Decision of the Russian Federation to support the regime of Bashar Assad in
its fight with terrorists and opposition became a crucial event in the world
politics with the long-term consequences for global international relations,
for the future of the Middle East and for Russia itself. One of the most
important questions in this context is why Kremlin decided to interfere and
what are the political and military lessons of its campaign in Syria? It can be
said that the main political goal of Vladimir Putin was to make the United
States take Russia into account as a serious (if not equal) player in the
international arena, and he reached that goal, making his state a key factor
in the Middle East. There was a doubt if Russian army is able to act
effectively abroad and change Syrian situation at low cost. It proved that it is
efficient enough, showing the advantages of Russian weaponry, and got
valuable experience in many spheres. At the same time, the end of the
Kremlin game in Syria is not clear, but this can be an inevitable price of its
revived imperial ambitions.
Life after ISIS: the problem of the Islamic State foreign fighters
Authors: Ciślar Aleksandra
Published: December 2019

After the collapse of the Islamic State of Iraq and Syria many states faced the
problem of the foreign fighters wanting to return. Some governments refused to
accept their citizens arguing that they pose too much of a threat to the public.
Are the governments across the world justified to revoke the citizenships of the
former members of the Caliphate? Do states have a responsibility for their own
citizens and are obligated to help them no matter the circumstances? These are
the questions that this article examines from the legal and political point of
view. The article examines a high profile case study of Shamima Begun –
a former jihadi wife, who travelled to Syria as a teenager, caught in a battle for
her British citizenship
The Dragon and the Condor: China’s rise and Latin America’s developmental anxieties
Authors: Gasperin Henrique Brenner , Guerra Lucas
Published: December 2019

In the present article, we aim to present a critical analysis of China’s rise
to the position of global power in the international scenario focused on
some related political inflexions in Latin America. Holding on a qualitative
methodology, based on the analysis of primary and secondary sources, we
argue that China’s rise and its growing presence in Latin America, mostly
regarding commercial and financial flows and also infrastructural project,
is reinforcing a neo-extractivist paradigm the new hegemonic model
of development for the region. This process has been generating a series
of social and environmental conflicts, providing us a space to discuss the
ambivalence and the contradictions presented in Chinese discourse, which
alludes to the establishment of a pacific world order that is committed
to ecologic sustainability, win-win relations, and the harmonious development
of the actors in the international scenario. This work will be critically
oriented by some concepts presented in contemporary Latin American
developmental thought. Some examples are neoextractivism, com-modity
consensus and reprimarization. For us to better situate the discussion, some
illustrative cases will be brought to the fore
Effect of Increasing the Plasma Phospholipase A2
Mass on the Risk of Masked Hypertension in Humans
Authors: Yan Gao , Ling Li , Yuan ChenXiao , Ying ChenChuan
Published: December 2019

Background: Masked Hypertension (MHT) is associated with an increased risk for Cardiovascular Disease (CVD). The etiopathogenesis of MHT is thought to be affected by oxidative stress and vascular inflammation. This study aimed to analyze the relationships between Lipoprotein-Associated Phospholipase A2 (Lp-PLA2), a unique vascular inflammation marker, with blood pressure variation and traditional risk factors in patients with MHT, and to determine the clinical significance.
Methods: One hundred eighty-three patients without any prior therapeutic medications were included and divided into the following three groups: MHT (n=82); True Hypertension (THT) [n=52]); and normotensive (n=59). An Ambulatory Blood Pressure Monitor (ABPM) was used. Clinical biochemical parameters and the Lp-PLA2 mass in each group were measured, and the related clinical characteristics and risk factors for CVD were statistically analyzed.
Results: The level of Lp-PLA2 in MHT group was significantly higher than the normotensive (191.8 ± 62.58 vs.108.3 ± 44.74 ng/ml, p<0.01) and true hypertension groups (191.8 ± 62.58 vs. 169.3 ± 54.55 ng/ml, p<0.05). Furthermore, the incidence of MHT was correlated with the increase in Lp-PLA2, around 65% of MHT patients with a Lp-PLA2 level ≥ 225 μ mol/L. The Lp-PLA2 level had a positive correlation with ABPM measurements, office-measured systolic blood pressure, and serum Uric Acid (UA) and Low-Density Lipoprotein Cholesterol (LDL-C) levels, but a negative correlation with the High-Density Lipoprotein Cholesterol (HDL-C) level.
Conclusion: An increased LP-PLA2 level was closely associated with the metabolic stress and incidence of MHT, thus exhibit an important role in the pathophysiology and diagnostic assessment of MHT.
Does Pancasila Support Religious Pluralism in Indonesia in Postmodern Era
Authors: Chia Philip Suciadi , Lontoh Frederich Oscar , Permana Surja , Juanda Juanda , Wibowo Daniel Ari
Published: December 2019

Since Indonesia is also one of the most diverse societies in the world such as there are over three hundred different ethnic groups in Indonesia, each with its own cultural identity, and more than two hundred and fifty distinct languages are spoken, then Pancasila is created as philosophic fundamentals of the state to supports the diversity in Indonesia. Pancasila (from a Sankrit word: panca: five and sila: principle) consists of five principles that are interrelated and inseparable to generate unity in diversity (bhinnekatunggalika). In this paper, I will argue that Pancasila promotesand facilitates religious diversity although religious culture in Indonesia does not promote religious pluralism.
An Integrated Yield Prediction Model for Greenhouse Tomato
Authors: Lin Dingyi , Wei Ruihua , Xu Lihong
Published: December 2019

The commonly used greenhouse crop yield prediction models today have their specific application scenarios, which may not ensure the accuracy of the results if the greenhouse environment changes. This greatly restricts their use in the greenhouse environment. To solve this problem, two widely used tomato growth models were compared in the study: TOMGRO and Vanthoor, and then an integrated model was obtained. Through the extended Fourier amplitude sensitivity test (EFAST), the model parameters were divided into three categories: optimized, fixed and ignored. In addition, Bayesian optimization was used as an optimization algorithm, through which the parameters applicable to the greenhouse can be optimized based on the greenhouse data. Compared with TOMGRO and Vanthoor, the output of the integrated model was more reasonable and universal, and the RMSE in the integrated model was 2.5974 while that in TOMGRO and Vanthoor both were over 17, reflecting the fact that the model output was closer to the actual value. According to the verification results of four-year greenhouse data, the model had high performance in predicting yield.
Trot Accelerations of Equine Front and Hind Hooves Shod with Polyurethane Composite Shoes and Steel Shoes on Asphalt
Authors: Moore Lauren Veneta , Zsoldos Rebeka Roza , Licka Theresia Franziska
Published: December 2019

The present study investigated accelerations of the front and hind hooves of horses comparing two different shoe types. A standard steel shoe, with studs, pins, and in some instances with toe grabs, was compared to a steel shoe covered on the bottom with a layer of polyurethane. Four horses were used; they trotted in hand on an asphalt track at their self-selected speed. The results showed significantly reduced decelerations during the stance phase with the polyurethane-covered shoes (10th percentile median steel −2.77 g, polyurethane −2.46 g; p = 0.06) and significantly increased decelerations in front hooves compared to hind hooves with steel shoes (70th percentile median −1.04 g front hooves, 0.12 g hind hooves, p = 0.04). Horses trotted faster using longer strides with the polyurethane-covered shoes compared to the steel shoes. The results show that effects of shoe types should be investigated simultaneously in front and hind hooves, and that PU shoes may aid in reducing the overload present in the front limbs of horses.
Seaweeds in Pig Nutrition
Authors: Corino Carlo , Modina Silvia Clotilde , Di Giancamillo Alessia , Chiapparini Sara , Rossi Raffaella
Published: December 2019

Seaweeds are macroalgae, with different sizes, colors and composition. They consist of brown algae, red algae and green algae, which all have a different chemical composition and bioactive molecule content. The polysaccharides, laminarin and fucoidan are commonly present in brown seaweeds, ulvans are found in green seaweeds and, red algae contain a large amount of carrageenans. These bioactive compounds may have several positive effects on health in livestock. In order to reduce the antimicrobials used in livestock, research has recently focused on finding natural and sustainable molecules that boost animal performance and health. The present study thus summarizes research on the dietary integration of seaweeds in swine. In particular the influence on growth performance, nutrients digestibility, prebiotic, antioxidant, anti-inflammatory, and immunomodulatory activities were considered. The review highlights that brown seaweeds seem to be a promising dietary intervention in pigs in order to boost the immune system, antioxidant status and gut health. Data on the use of green seaweeds as a dietary supplementation seems to be lacking at present and merit further investigation.
The Demography and Practice of Australians Caring for Native Wildlife and the Psychological, Physical and Financial Effects of Rescue, Rehabilitation and Release of Wildlife on the Welfare of Carers
Authors: Englefield Bruce , Candy Steve , Starling Melissa , McGreevy Paul
Published: December 2019

The rescue, rehabilitation and release of injured and orphaned Australian wildlife is managed by over 20,000 carers, mostly voluntarily. These volunteers experience mental, physical and financial challenges that have not been researched adequately. This study collated the responses (n = 316) to a survey conducted among Australian wildlife carers who actively foster orphaned joeys for hand-raising and injured adult mammals for rehabilitation and release. It confirmed 86% of rehabilitators are female, 70% are over the age of 46 years and their prime motivation is an affinity with animals. The average time spent in the sector is 11.5 years, and the work week is 31.6 h, caring for 15 animals per year, with an average of 2.6 dying. The average financial commitment is AUD5300 annually and up to AUD800,000 over a lifetime. Regarding the grief experienced by carers, the lower the age, the longer the time spent, the greater the financial input and the more joeys that died, the more severe is the grief experienced. Moderate to severe grief is experienced by 28% of carers, which, coupled with other factors, could lead to burnout or compassion fatigue. Soon, wildlife carer welfare will likely be compromised unless financial and mental support is provided and their workload reduced.