bluuebunny/crossref_metadata_2025 huggingface dataset:
The microbial environment modulates non-genetic maternal effects on egg immunity
Authors: van Veelen H. Pieter J. , Salles Joana Falcão , Matson Kevin D. , van Doorn G. Sander , van der Velde Marco , Tieleman B. Irene
Published: July 2022

Background

In a diverse microbial world immune function of animals is essential. Diverse microbial environments may contribute to extensive variation in immunological phenotypes of vertebrates, among and within species and individuals. As maternal effects benefit offspring development and survival, whether females use cues about their microbial environment to prime offspring immune function is unclear. To provide microbial environmental context to maternal effects, we asked if the bacterial diversity of the living environment of female zebra finchesTaeniopygia guttatashapes maternal effects on egg immune function. We manipulated environmental bacterial diversity of birds and tested if females increased immunological investment in eggs in an environment with high bacterial diversity (untreated soil) versus low (gamma-sterilized soil). We quantified lysozyme and ovotransferrin in egg albumen and IgY in egg yolk and in female blood, and we used 16S rRNA gene sequencing to profile maternal cloacal and eggshell microbiotas.

Results

We found a maternal effect on egg IgY concentration that reflected environmental microbial diversity: females who experienced high diversity deposited more IgY in their eggs, but only if maternal plasma IgY levels were relatively high. We found no effects on lysozyme and ovotransferrin concentrations in albumen. Moreover, we uncovered that variation in egg immune traits could be significantly attributed to differences among females: for IgY concentration in yolk repeatabilityR = 0.80; for lysozyme concentration in albumenR = 0.27. Furthermore, a partial least squares path model (PLS-PM) linking immune parameters of females and eggs, which included maternal and eggshell microbiota structures and female body condition, recapitulated the treatment-dependent yolk IgY response. The PLS-PM additionally suggested that the microbiota and physical condition of females contributed to shaping maternal effects on egg immune function, and that (non-specific) innate egg immunity was prioritized in the environment with low bacterial diversity.

Conclusions

The microbial environment of birds can shape maternal effects on egg immune function. Since immunological priming of eggs benefits offspring, we highlight that non-genetic maternal effects on yolk IgY levels based on cues from the parental microbial environment may prove important for offspring to thrive in the microbial environment that they are expected to face.
Dancing in an Enclosure
Authors: Cruz-Malavé Arnaldo M.
Published: July 2022

An examination of the significance of dance performances in the demonstrations of the Puerto Rican summer of 2019, this essay argues that these performances belong to a history of irreverent, extravagant mourning gestures that periodically irrupt in Puerto Rican culture as decolonial practices by dislocating the socially prescribed binding between performance and affect. Using the theories of Saidiya Hartman, José Esteban Muñoz, and Juana María Rodríguez, and connecting to the work of Rocío Zambrana on strategies that address the island’s colonial legacy, the essay explores the mournfully irreverent dance performances of the Afro-Boricua bomba dancer Clara Isabel Díaz, the patería combativa (combative queer voguing) of Aldrin Manuel Cañals, and the reggaetón perreo of queer feminist activists Perra Mística and Kaya Té as gestures of loss and mourning that both demand redress and enact what Puerto Rican artists, activists, and critics have begun to call “decolonial joy.”
At the Crossroads of Many Worlds
Authors: Haffner Peter L.
Published: July 2022

The late Marilyn Houlberg (1939–2012) was an artist, photographer, art historian, anthropologist, professor, curator, and collector. During her lifetime she helped advance the scholarship on and increase the recognition of artists from Haiti, particularly in her role as cocurator of the exhibitions Sacred Arts of Haitian Vodou (1995) and In Extremis: Death and Life in Twenty-First-Century Haiti (2012). In her commitment to support the creative endeavors of artists living in historically marginalized communities in urban Haiti, Houlberg blurred cultural and professional boundaries, raising questions about her roles and responsibilities within the communities of artists and religious practitioners with whom she worked. This essay addresses problems and complexities in Houlberg’s work and activities in Haiti by relying on her extensive field notes, photographs, published works, and other archival materials.
What Happens to Black in the Afro-Surinamese Transatlantic Diaspora?
Authors: Wekker Gloria
Published: July 2022

This essay tells a narrative of various contexts in the Afro-Surinamese diaspora that share a struggle around the meanings of Black. What happens to Black in the Afro-Surinamese transatlantic diaspora? Some of the questions addressed are, Which terms have African descendant people in Suriname and in the Netherlands used for themselves in different periods? What have Whites called African descendant people in Suriname and in the Netherlands in different periods? When does Black come to the fore? Who mobilizes the term and for what purposes? This exercise brings forward important features of the Afro-Surinamese “cultural archive”: the orderings of the world, specifically the terms of ethnic self-reference, that Afro-Surinamese forged historically. These terms also traveled to the Netherlands, where they met with clashing cultural-political terms and understandings in the dominantly White Dutch world.
Transnational Renderings of Negro/a/x/*
Authors: Zamora Omaris Z.
Published: July 2022

This essay takes on the task of reflecting on the keyword negro from a transnational standpoint that considers how negro/a/x, a sociopolitical identity, falls in and out of AfroLatinidad in Latin American and hispanic Caribbean diasporas. In particular, the author is concerned with re-centering Blacknesss in AfroLatinidad in response to the depoliticized usage of this identity. Through a focus on diaspora, movement, and the embodied fact of Blackness, the author argues that when thinking about negro (Black) and negritud (Blackness) from a transnational Spanish Caribbean context, we should remember that AfroLatinidad, or Black Latinidad, is first and foremost about Black lives, embodied experiences, movement, translatability, and untranslatability.
Nègre (Noir, Black, Renoi, Négro)
Authors: Pierrot Grégory
Published: July 2022

This essay presents and studies five different words used in French to express the notion of Blackness. The five words analyzed—nègre, noir, black, renoi, and négro—entered the French language between the beginning of the Atlantic slave trade in the sixteenth century and the 1980s and were often borrowed from other languages. The way the terms have been and continue to be used illustrates France’s complicated and shifting relation to people of African descent, notably within its own population. In the context of culture wars that have been shaking the country in the past decades and have seen the rise of organized Black political groups on the French public stage, how one speaks Blackness in France has become especially fraught.
To Be Black Is to . . .
Authors: Welcome Leniqueca A.
Published: July 2022

This essay shows that despite the variegated experience of Black-identified people globally and the unstable and processual nature of Blackness as a category, the meaning of Blackness remains anchored in the geography of the plantation, and the deathliness this produces still haunts the anglophone Caribbean. The focus is on how this haunting is palpable to the criminalized urban poor in Trinidad; yet Black has never simply denoted abjection. From the vantage point of postcolonial Caribbean nation-states founded on anticolonial projects of Black sovereignty, one can see not only the resilience of anti-Blackness that conditions what it feels like to be Black but also what Katherine McKittrick calls the “iterations of Black life that cannot be contained by black death.”
Everything Slackens in a Wreck
Authors: Gosine Andil
Published: July 2022

This is a curatorial essay in which the author explains his research and process for the conception and production of everything slackens in a wreck, a visual arts exhibition running at the Ford Foundation Gallery in New York from June to September 2022. Gosine elaborates his thinking about the title of the exhibition, which is taken from a Khal Torabully poem, and explains the relevance of and his intrigue with the four artists whose works comprise the exhibition: Wendy Nanan (Trinidad and Tobago), Margaret Chen (Jamaica/Canada), Andrea Chung (Jamaica/United States), and Kelly Sinnapah Mary (Guadeloupe). Each of the four women is a descendant of indentured workers who traveled to the Caribbean in the late nineteenth and early twentieth centuries, and for each this history is a reference point in her practice. Gosine proposes a consideration of the Americas as a consequence of three wreckages: the ship landings of European colonizers and the arriving ships of enslaved and, later, indentured peoples.
Sensorial Errancy in Decolonial Key
Authors: Zambrana Rocío
Published: July 2022

This reflection on Ren Ellys Neyra’s The Cry of the Senses: Listening to Latinx and Caribbean Poetics (2020) engages their reading of Beatriz Santiago Muñoz’s cinema, paying particular attention to sensorial actualities that offer apprehension of the past of colonial violence that is the present. It focuses in particular on Santiago Muñoz’s Otros Usos (2014), which specifically explores Vieques, Puerto Rico. To apprehend the past that is the present requires indexing the continuity of the plantation economy, and thus its racial order, in the military complex, in the tourist economy, and in the current rounds of colonial settlement through tax haven conditions in the realm of real estate. The essay shifts the language of anticolonial sensorial errancy to decolonial sensorial errancy to focus on the forms of “slow violence” of economic invasion/ control, the productivity of which presses us to attend to the forms of insidious, ubiquitous racial violence they represent.
Modern Dermabrasions
Authors: Mendoza-de Jesús Ronald
Published: July 2022

This essay sketches out a protocol for reading Ren Ellis Neyra’s The Cry of the Senses: Listening to Latinx and Caribbean Poetics (2020) from the vantage point of Ellis Neyra’s more recent work on Brownness and (non)relation. The essay aims to explore further the tensions that Ellis Neyra has identified across the fault lines of “Black/Brown” racial formations in a post-1492 context by paying specific attention to how these tensions crystalize in Latinx, Latin American, and Caribbean studies. The essay unpacks Ellis Neyra’s account of the breakdown of the concept of Brownness as articulated in José Estebán Muñoz’s work in order to detect an analogous breakdown in Bolívar Echevarría’s influential work on racial modernity. In conclusion, the essay poses a question about the emancipatory potential of abjection by putting Ellis Neyra’s compelling reading of Pedro Pietri’s The Masses Are Asses in dialogue with the work of the late feminist-deconstructionist thinker Mara Negrón.
Imaging three-dimensional brain organoid architecture from meso- to nanoscale across development
Authors: Rodriguez-Gatica Juan Eduardo , Iefremova Vira , Sokhranyaeva Liubov , Yeung Si Wah Christina Au , Breitkreuz Yannik , Brüstle Oliver , Schwarz Martin Karl , Kubitscheck Ulrich
Published: July 2022

Organoids are stem cell-derived three-dimensional cultures offering a new avenue to model human development and disease. Brain organoids allow the study of various aspects of human brain development in the finest details in vitro in a tissue-like context. However, spatial relationships of subcellular structures, such as synaptic contacts between distant neurons, are hardly accessible by conventional light microscopy. This limitation can be overcome by systems that quickly image the entire organoid in three dimensions and in super-resolution. To that end we have developed a system combining tissue expansion and light-sheet fluorescence microscopy for imaging and quantifying diverse spatial parameters during organoid development. This technique enables zooming from a mesoscopic perspective into super-resolution within a single imaging session, thus revealing cellular and subcellular structural details in three spatial dimensions, including unequivocal delineation of mitotic cleavage planes as well as the alignment of pre- and postsynaptic proteins. We expect light-sheet fluorescence expansion microscopy to facilitate qualitative and quantitative assessment of organoids in developmental and disease-related studies.
The fetal lineage is susceptible to Zika virus infection within days of fertilization
Authors: Watts Jennifer L. , Ralston Amy
Published: July 2022

Adults contracting Zika virus (ZIKV) typically exhibit mild symptoms, yet ZIKV infection of pregnant individuals can cause miscarriage or birth defects in their offspring. Many studies have focused on maternal-to-fetal ZIKV transmission via blood and placenta. Notably, however, ZIKV is also transmitted sexually, raising the possibility that ZIKV could infect the embryo shortly after fertilization, long before the placenta is established. Here, we evaluate the consequences of ZIKV infection in mouse embryos during the first few days of embryogenesis. We show that divergent strains of ZIKV can infect the fetal lineage and can cause developmental arrest, raising concern for the developmental consequences of sexual ZIKV transmission.

This article has an associated ‘The people behind the papers’ interview.
Rapid and robust directed differentiation of mouse epiblast stem cells into definitive endoderm and forebrain organoids
Authors: Medina-Cano Daniel , Corrigan Emily K. , Glenn Rachel A. , Islam Mohammed T. , Lin Yuan , Kim Juliet , Cho Hyunwoo , Vierbuchen Thomas
Published: July 2022

Directed differentiation of pluripotent stem cells (PSCs) is a powerful model system for deconstructing embryonic development. Although mice are the most advanced mammalian model system for genetic studies of embryonic development, state-of-the-art protocols for directed differentiation of mouse PSCs into defined lineages require additional steps and generates target cell types with lower purity than analogous protocols for human PSCs, limiting their application as models for mechanistic studies of development. Here, we examine the potential of mouse epiblast stem cells cultured in media containing Wnt pathway inhibitors as a starting point for directed differentiation. As a proof of concept, we focused our efforts on two specific cell/tissue types that have proven difficult to generate efficiently and reproducibly from mouse embryonic stem cells: definitive endoderm and neural organoids. We present new protocols for rapid generation of nearly pure definitive endoderm and forebrain-patterned neural organoids that model the development of prethalamic and hippocampal neurons. These differentiation models present new possibilities for combining mouse genetic tools with in vitro differentiation to characterize molecular and cellular mechanisms of embryonic development.
Arih2 regulates Hedgehog signaling through smoothened ubiquitylation and ER-associated degradation
Authors: Lv Bo , Zhang Xiao-Ou , Pazour Gregory J.
Published: July 2022

During Hedgehog signaling, the ciliary levels of Ptch1 and Smo are regulated by the pathway. At the basal state, Ptch1 localizes to cilia and prevents the ciliary accumulation and activation of Smo. Upon binding a Hedgehog ligand, Ptch1 exits cilia, relieving inhibition of Smo. Smo then concentrates in cilia, becomes activated and activates downstream signaling. Loss of the ubiquitin E3 ligase Arih2 elevates basal Hedgehog signaling, elevates the cellular level of Smo and increases basal levels of ciliary Smo. Mice express two isoforms of Arih2 with Arih2α found primarily in the nucleus and Arih2β found on the cytoplasmic face of the endoplasmic reticulum (ER). Re-expression of ER-localized Arih2β but not nuclear-localized Arih2α rescues the Arih2 mutant phenotypes. When Arih2 is defective, protein aggregates accumulate in the ER and the unfolded protein response is activated. Arih2β appears to regulate the ER-associated degradation (ERAD) of Smo preventing excess and potentially misfolded Smo from reaching the cilium and interfering with pathway regulation.
Synthesis, Structures, and Redox Behavior of Methyl-Substituted Derivatives of Thiophene-Inserted [3]Dendralene with Redox-Active 1,3-Dithiol-2-ylidene Units
Authors: Ito Toshiki , Ueda Masafumi , Fujisaki Masahiro , Yoshimura Aya , Shirahata Takashi , Misaki Yohji
Published: July 2022

Several derivatives of 1,3-dithiole[3]dendralene with one thiophene spacer (1) were newly prepared. X-ray structure analysis of the hexamethyl-1 (1Aa) revealed that 1Aa adopts a structure with significant distortion between the central 1,3-dithiole (DT) ring and the thiophene ring. Cyclic voltammograms of all the derivatives were composed of three pairs of one-electron redox waves in correspondence with the presence of three redox-active DT rings. The results of cyclic voltammetry and spectroelectrochemistry indicated that a positive charge in 1Aa•+ is mainly delocalized on the vinyl-extended tetrathiafulvalene (TTF) moiety, while two positive charges in 1Aa2+ are mainly distributed on the thiophene-inserted TTF moiety. X-ray structure analysis revealed that two-electron oxidation of 1Aa with (4-BrC6H4)3N•+SbCl6− gradually facilitated the formation of a dicationic species of its chlorinated product.
O varejo não será mais o mesmo
Authors: Bernardes Vanessa Santolin , Guissoni Leandro Angotti
Published: July 2022

Os desafios e caminhos para a transformação digital, indispensável para varejistas atenderem aos consumidores, os quais já haviam mudado seus hábitos de consumo antes da pandemia e agora intensificaram as compras nos canais virtuais.
Estados e municípios no combate à Covid-19
Authors: Franzese Cibele
Published: July 2022

Diante de uma ação negacionista do governo federal, estados e municípios puderam, de forma mais ou menos coordenada, agir em defesa da vida dos brasileiros.
Konzepte und Praxen der musikalischen Ausbildung am Beispiel der einstimmigen liturgischen Musik der Ost- und Westkirche vom Mittelalter bis zum 21. Jahrhundert
Authors: Γιανγκιτσέρη Μαρία
Published: July 2022

Η παρούσα διατριβή πραγματεύεται τη διδακτική και τη μεθοδολογία της διδασκαλίας του Γρηγοριανού Μέλους στη Γερμανία και της Βυζαντινής Μουσικής στην Ελλάδα, την οργάνωση της εκπαίδευσης σε αυτούς τους τομείς, τα διδακτικά εγχειρίδια καθώς και την λειτουργική πράξη αυτών των μουσικών παραδόσεων, εν μέρει στον Μεσαίωνα αλλά κυρίως στον 21ο αιώνα. Μεγάλο μέρος της έρευνας βασίστηκε στις μεθόδους της ποιοτικής κοινωνικής έρευνας (συμμετοχική παρατήρηση, συνεντεύξεις, ερωτηματολόγια κ.α.). Οι καινοτομίες αυτής της εργασίας έγκεινται πρώτα απ' όλα στην αντιπαράθεση και σύγκριση αυτών των μουσικών παραδόσεων. Σημαντική συμβολή στη διδακτική και τη μεθοδολογία, αλλά γενικότερα στη μουσική παιδαγωγική σκέψη, είναι η συλλογή και ανάλυση των συνεντεύξεων, που περιλάμβαναν όλα τα σημαντικά πρόσωπα του κλάδου (ερμηνευτές, δάσκαλοι, επιστήμονες) από όλες σχεδόν τις περιοχές της Ελλάδας και της Γερμανίας. Ιδιαίτερα αξιοσημείωτες είναι οι δηλώσεις του Πρωτοψάλτη του Οικουμενικού Πατριαρχείου Κωνσταντινουπόλεως Παναγιώτη Νεοχωρίτη, που αντανακλούν μια ορισμένη «φιλοσοφία» της μουσικοπαιδαγωγικής. Επιπλέον, η παρουσίαση πραγματικών διδακτικών καταστάσεων σε όλες τις βαθμίδες της εκπαίδευσης και στις δύο χώρες αποτελεί σημαντική τεκμηρίωση για το διδακτική πραγματικότητα της μονοφωνικής λειτουργικής μουσικής στον 21ο αιώνα. Μια άλλη συνεισφορά είναι η ιστορία (εξέλιξη) της διδασκαλίας του μαθήματος «Βυζαντινή Μουσική» στα τέσσερα πανεπιστημιακά τμήματα Μουσικών Σπουδών της Ελλάδας και τις Ανώτατες Εκκλησιαστικές Ακαδημίες από την ίδρυσή τους μέχρι περίπου το έτος 2020 βάσει των προγραμμάτων σπουδών και άλλων σχετικών εγγράφων.
Η κατανόηση της πυκνής διάταξης των ρητών από μαθητές Β΄ Λυκείου: ένα διδακτικό πείραμα
Authors: Φωκάς Δημήτρης , Βαμβακούση Ξένια
Published: July 2022

Η μετάβαση από τους φυσικούς στους ρητούς αριθμούς παρουσιάζει δυσκολίες για τους μαθητές, μέρος των οποίων οφείλεται στην καταχρηστική μεταφορά γνώσης για τους φυσικούς στους ρητούς. Μια ιδιότητα των φυσικών αριθμών που μεταφέρεται καταχρηστικά στους ρητούς είναι η διακριτότητα: Αντίθετα με το σύνολο των ρητών αριθμών, το σύνολο των φυσικών αριθμών είναι διακριτά διατεταγμένο, δηλαδή, για κάθε φυσικό αριθμό ορίζεται ο επόμενός του. Οι ρητοί αριθμοί είναι πυκνά διατεταγμένοι, δηλαδή, δεν ορίζεται ο επόμενος για κανέναν αριθμό στο σύνολο αυτό. Η προσέγγιση της θεωρίας πλαισίου στην εννοιολογική αλλαγή προβλέπει ότι οι θεμελιώδεις παραδοχές των μαθητών για τον αριθμό ως φυσικό δεν αίρονται δια μιάς, με την ιδέα της διακριτότητας να είναι ιδιαίτερα ανθεκτική. Στην εργασία παρουσιάζεται ένα διδακτικό πείραμα με 15 μαθητές Λυκείου. Εξετάσαμε την υπόθεση ότι διαφορετικές πτυχές της πυκνότητας των ρητών αριθμών (συγκεκριμένα, η απειρία των ρητών σε οποιοδήποτε διάστημα και η μη ύπαρξη του επόμενου), παρότι μαθηματικά ισοδύναμες, παρουσιάζουν διαφορετικές δυσκολίες για τους μαθητές. Η αρχική κατανόηση των μαθητών για την πυκνότητα ελέγχθηκε ατομικά. Κάθε μαθητής ξεχωριστά συμμετείχε σε μικρής διάρκειας παρέμβαση, στην οποία εισήχθη η ιδέα του αριθμητικού μέσου ενός διαστήματος ως εργαλείο που δυνητικά μπορεί να οδηγήσει στην κατανόηση και των δύο πτυχών της πυκνής διάταξης. Τέλος, κάθε μαθητής επανεξέτασε τις απαντήσεις του στα έργα του προελέγχου και παρακινήθηκε να αξιοποιήσει την ιδέα του αριθμητικού μέσου. Τα αποτελέσματα δείχνουν ότι οι μαθητές συνέχισαν να θεωρούν ότι υπάρχει ο επόμενος στους ρητούς, ακόμα και όταν συμπέραναν την απειρία των ενδιάμεσων. Υπό το πρίσμα της θεωρίας που υιοθετήσαμε, η αντίληψη αυτή είναι συνθετική, καθώς οι μαθητές αλλάζουν μερικώς την αντίληψή τους για τη διάταξη των ρητών, χωρίς να αίρεται η αρχή του επόμενου αριθμού.
Μεροληψία κοινής μεθόδου στους ερευνητικούς σχεδιασμούς με τη χρήση εργαλείων αυτoαναφοράς: βιβλιογραφική επισκόπηση και προτεινόμενες τεχνικές αντιμετώπισης
Authors: Καλτσονούδη Καλλιόπη , Τσιγγίλης Νικόλαος , Καρτερολιότης Κωνσταντίνος
Published: July 2022

Ένα από τα πιο πολυσυζητημένα και αμφιλεγόμενα μεθοδολογικά και στατιστικά ζητήματα που απασχολούν τους ερευνητικούς σχεδιασμούς με τη χρήση εργαλείων αυτοαναφοράς είναι η μεροληψία κοινής μεθόδου, η οποία ενδέχεται να εμφανιστεί όταν τα δεδομένα για τις μεταβλητές πρόβλεψης και κριτηρίου προέρχονται από το ίδιο άτομο χρησιμοποιώντας την ίδια μέθοδο απόκρισης. Η μη ελεγχόμενη διακύμανση μεθόδου μπορεί να παράγει μεροληπτικές εκτιμήσεις της αξιοπιστίας και της εγκυρότητας των υποκείμενων εννοιών και λανθασμένες παραμετρικές εκτιμήσεις στις σχέσεις μεταξύ των εννοιών. Σκοπός της παρούσας εργασίας είναι η επισκόπηση της βιβλιογραφίας γύρω από τις έννοιες της μεροληψίας και της διακύμανσης κοινής μεθόδου. Τα 143 άρθρα που προήλθαν από τη σύνθετη αναζήτηση σχετικών μελετών σε τέσσερις βάσεις δεδομένων κατέδειξαν τις βασικές θεματικές ενότητες της εργασίας αυτής. Η κλασική θεωρία μέτρησης χρησιμοποιήθηκε για να εξηγηθούν οι πηγές σφαλμάτων μέτρησης και οι επιπτώσεις της διακύμανσης κοινής μεθόδου. Στη συνέχεια, έγινε περιγραφή των κυρίαρχων μεθοδολογικών και στατιστικών τεχνικών προσδιορισμού και ελέγχου της διακύμανσης κοινής μεθόδου. Οι πιθανές επιδράσεις της διακύμανσης κοινής μεθόδου στην έρευνα με ερωτηματολόγια αυτοαναφοράς είναι περίπλοκες και δυσνόητες, όμως, παρά την υπάρχουσα διαφωνία αναφορικά με τη φύση και την έκτασή της, οι ερευνητές από τον χώρο της ψυχολογίας και των κοινωνικών ή οργανωσιακών επιστημών θα πρέπει να λαμβάνουν μέτρα ελαχιστοποίησης της μεροληψίας μεθόδου.
Measuring the impact of publicly funded open innovation programmes: the case of Data Market Services Accelerator
Authors: Priestley Maria , Simperl Elena , Juc Cristina , Anguiano María
Published: July 2022

One of the current goals of the European Commission is to stimulate the development and uptake of data and AI technologies in the economy. Earlier foundations of this work included initiatives to promote the publication of open data in the public domain. More recently, the Commission’s attention has been shifting to open innovation programmes that help startups and small-medium enterprises (SMEs) to develop the capacity to engage with the latest technical and regulatory trends, and to share their data innovations with other organisations. In order to assess the efficacy and impact of such initiatives, each programme’s specific social and economic objectives must be taken into consideration. As an example of how this can be done in practice, our paper presents the motivating objectives and methodological approaches that were used to assess the impact of the Data Market Services Accelerator (DMS), an EU-funded initiative for data-centric companies. We evaluated the performance of the programme in terms of its effect on the market, fundraising capabilities of companies, innovation, and socio-economic aspects. In addition to assessing how DMS was able to meet its intended objectives, our examination also underscored current challenges related to specific outcomes that are meaningful to the European Commission, including data standardisation and long-term legal strategy. We conclude the paper with a series of recommendations to support the impact assessment efforts of other similar innovation programmes.
A living mapping review for COVID-19 funded research projects: 15 month update
Authors: Bucher Adrian , Antonio Emilia , Grund Henrike , Jabin Nusrat , Jones Chantel , Kifle Meron , Khader Susan , Boily-Larouche Genevieve , Lay Morgan , Norton Alice
Published: July 2022

Background: The coronavirus disease 2019 (COVID-19) has resulted in an unprecedented research response, demonstrating exceptional examples of rapid research and collaboration. There has however been an ongoing  need for greater coordination, with limited resources for research  and the shifting global nature of the pandemics.

Methods: The UK Collaborative on Development Research (UKCDR) and Global Research Collaboration for Infectious Disease Preparedness (GloPID-R), two funder coordination groups have collaborated to develop a live database of funded research projects across the world relating to COVID-19. Drawing data continually from their members and further global funding bodies, as of 15th October 2021 the database contains 13,484 projects, funded by 285 funders, taking place across 156 countries representing an investment of at least $5.1 billion. To our knowledge it is one of the most comprehensive databases. The database is aligned to the World Health Organisation and GloPID-R Global Research Roadmap: 2019 Novel Coronavirus. It is being used by the WHO, governments and multi-lateral policy makers, research funders and researchers.

This living mapping review aims to supplement the database by providing an open accessible and frequently updated resource summarising the characteristics of the COVID-19 funded research portfolio. Both descriptive and thematic analysis will be presented and updated frequently to aid interpretation of the global COVID-19 funded research portfolio.

Results: In this version six analysis we provide an updated detailed descriptive analysis of the database (on data from three months after version five) and focus our thematic analysis on research gaps, research areas in need of coordination, study populations and research locations (with a focus on resource-limited countries).

Conclusions: As the global funding response to COVID-19 plateaus, this living mapping review helps both funders and researchers to prioritise resources to areas where there is continued unmet research need.
Longevity, fertility, and average eggs viability of parthenogenetic females of Cladomorphus phyllinus Gray (Phasmatodea - Phasmatidae)
Authors: Torres Lucas da Silva , Benítez Hugo Alejandro , Costa Jane
Published: July 2022

The order Phasmatodea includes insects known as stick insects. In Brazil, few taxonomic, ecological or evolutionary studies have been published in recent years, the reason is related to the few number of researchers dedicated to this particular group. Cladomorphus phyllinus Gray is one of the largest Brazilian insects and perhaps one of the most studied species of Phasmatodea in the country. It is considered as a phytophagous, generalist, and feeds mainly on guava leaves (Psidium guajava), powder-puff (Calliandra sp.) or Angico (Piptania sp.). Females of this species reproduce in a sexual and asexual manner, by the production of diploid daughters from unfertilized eggs (thelytokous parthenogenesis). The absence of records on the reproductive capacity of virgin parthenogenetic females of C. phyllinus led us to record the longevity, fertility, and eggs viability of ten specimens. The results obtained were compared to those found in the scientific literature for mated females of the same species. The fertility and eggs viability were observed to be much lower for the parthenogenetic females when compared to the mated females; however, the longevity for virgin females was longer than that recorded in the literature for mated females.
Keystone flap for reconstruction of ulnar side defect of the hand: a case report
Authors: Koh In Chang , Kim Jong Hyup , Kim Hoon , Lim Soo Yeon
Published: July 2022

Soft tissue defects of the hand may present in various forms and are often challenging to treat. The goal of surgical hand reconstruction includes both functional and aesthetic aspects. The keystone-design perforator island flap is a multi-perforator advancement flap with a safe flap harvesting technique, reliable blood supply, minimal donor site morbidity, and a simple dissection process that obviates the need for microsurgical techniques. Our patient was an 85-year-old man with squamous cell carcinoma on the left-hand ulnar side. The patient had difficulty in ambulation and used the affected area of the hand to stand up. Thus, we planned reconstruction using an omega-variant type B keystone flap to further reduce tension during flap insetting and to provide sufficient padding that would protect against excessive pressure postoperatively. The flap and donor site were closed primarily, without any postoperative complications. The patient was satisfied with the outcome after 19-month follow-up.
Distúrbios do sono e exercício físico regular na atenção primária à saúde: estudo observacional
Authors: Assunção Karina Nunes , Pasqualotto Luísa Teixeira , Campos Helton Oliveira , Faria Júnior Newton Santos
Published: July 2022

O exercício físico é considerado atualmente como alternativa não farmacológica para melhora da qualidadedo sono, porém pela falta de conhecimento de alguns profissionais o mesmo não é muito utilizado para essa finalidade. Dessa forma, o objetivo deste estudo foi comparar a qualidade do sono, a presença de distúrbios do sono e insônia, e a qualidade de vida em pacientes praticantes de exercício físico regular (PEFR) e não praticantes de exercício físico regular (NPEFR), assistidos em UBS´s do município de Divinópolis, Minas Gerais. O estudo foi do tipo observacional transversal, realizado com 49 pacientes recrutados a partir de Unidades Básicas de Saúde (UBS´s) do município de Divinópolis, Minas Gerais. Foram divididos em dois grupos, os PEFR e NPEFR, e em seguida avaliados quanto a qualidade e presença de distúrbios do sono, percepção da insônia, e qualidade de vida, abordados de acordo com os respectivos questionários: Índice de Qualidade de Sono de Pittsburgh (IQSP), Índice de Gravidade de Insônia e Questionário de Qualidade de Vida SF-36. Quando comparado os grupos, houve diferença estatisticamente significativa quanto aos itens boa qualidade do sono, presença de insônia severa, qualidade de vida sob os domínios estado geral de saúde, aspectos sociais e saúde mental. Desta forma, sugere-se que os pacientes que praticam exercício físico regular assistidos em UBS’s apresentam maior prevalência de boa qualidade do sono, menor índice de insônia severa e melhor qualidade de vida.
Multicriteria Course Mode Selection and Classroom Assignment Under Sudden Space Scarcity
Authors: Navabi-Shirazi Mehran , El Tonbari Mohamed , Boland Natashia , Nazzal Dima , Steimle Lauren N.
Published: July 2022

Problem definition: Although physical (or “social”) distancing is an important public health intervention during airborne pandemics, physical distancing dramatically reduces the effective capacity of classrooms. Academic/practical relevance: During the COVID-19 pandemic, this presented a unique problem to campus planners who hoped to deliver a meaningful amount of in-person instruction in a way that respected physical distancing. This process involved (1) assigning a mode to each offered class as remote, residential (in-person), or hybrid and (2) reassigning classrooms under severely reduced capacities to the non-remote classes. These decisions need to be made quickly and under several constraints and competing priorities, such as restrictions on changes to the timetable of classes, trade-offs between classroom density and educational benefits of in-person versus online instruction, and administrative preferences for course modes and classrooms reassignments. Methodology: We solve a flexible integer program and use hierarchical optimization to handle the multiple criteria according to priorities. We apply our methods using actual Georgia Institute of Technology (GT) student registration data, COVID-19–adjusted classroom and laboratory capacities, and departmental course mode delivery preferences. We generate optimal classroom assignments for all GT classes at the Atlanta campus and quantify the trade-offs among the competing priorities. Results: When classroom capacities decreased to 20%–25% of their normal seating capacities, optimization afforded students 15.5% more in-person contact hours compared with no room reassignments (NRRs). Among sections with an in-person preference, our model satisfies 87% of mode preferences, whereas only 47% are satisfied under NRR. Additionally, in a scenario in which all classes are preferred to be delivered in person, our model can satisfy 90% of mode preferences compared with 37% under NRR. Managerial implications: Multiobjective optimization is well suited for classroom assignment problems that campus planners usually manage sequentially and manually. Our models are computationally efficient and flexible, with the ability to handle multiple objectives with different priorities and build a new class-classrooms assignment or optimize an existing one, and they can apply under normal or sudden capacity scarcity constraints.

Funding: This work was supported by a grant from the Thos and Clair Muller Research Endowment Fund of the Georgia Institute of Technology’s H. Milton Stewart School of Industrial and Systems Engineering and a grant from the Georgia Institute of Technology Executive Vice President for Research COVID-19 Rapid Response Seed Grant Program.

Supplemental Material: The e-companion is available at https://doi.org/10.1287/msom.2022.1131 .
BEBERAPA FAKTOR RISIKO PENYAKIT GUDIKAN (SCABIES) DI PONDOK PESANTREN BINAUL UMMAH DESA BAWURAN, PLERET, BANTUL TAHUN 2018
Authors: Ubaidillah Ubaidillah , Khoiriah Nikmatul
Published: July 2022

Backgraund : Islamic Boarding Schools are Boarding Islamic schools where students usually stay with freinds in one room. Living with a group of people such as in a boarding schools is at risk of easily contracting various diseases including scabies. Scabies is less noticed in islamic boarding school so that it can cause health problem that result from unhealthy behaviour in maintaining personal hygiene.Objective : to determine the factors correlation with the incidence of scabies in islamic boarding schools Binaul Ummah Village Bawuran, Pleret, Bantul.Method : The design of this study is an analytical survey with a case control design. The sampel of the study was 100 in the islamic boarding schools Binaul Ummah by using Purposive Sampling. Data collection using a knowledge, personal hgyiene,Â  density of residential questionnaires. Data analysis using Chi-Square.Result : the results of data analysis showed that knowledge is not correlation to the incidence of scabies P = 0,391, OR = 0,691. Clothes hygiene is correlation with the incidence of scabies P = 0,043. Hand an nail hygiene is correlation with the incidence of scabies P = 0,010. The cleanliness of Â the bed is correlation Â to the incidence of scabies P = 0,097. Occupancy density has correlation to the incidence of scabies P = 0,019.Conclusion : There is no correlation of knowledge with the incidence of scabies, there is a correlation between the cleanliness of clothes, hand and nail hygiene, cleanliness of the bed with the incidence of scabies and there is correlation residential density and incidience of scabies.Keyword : Scabies, Kwoledge, personal Hygiene,occupancy density
HUBUNGAN ANGKA BEBAS JENTIK (ABJ) DENGAN INSIDENCE RATE DEMAM BERDARAH DENGUE (DBD) DI TINGKAT KABUPATEN SLEMAN TAHUN 2013-2017
Authors: Sukesi Tri Wahyuni , Astuti Cincin Tri
Published: July 2022

Background : Dengue Hemorrhagic Fever (DHF) was widely found in tropical and sub-tropical regions. WHO noted Indonesia as a country with the highest DHF cases in Southeast Asia. DHF was an endemic disease, discovered in1954, entered Indonesia in 1968. In Sleman Regency, the number of DHF cases in2017 was 427 (IR 46.31 of 100,000 population with 3 deaths (CFR 0.7%). The number of cases was decreased, compared to 2016. That was recorded at 880 cases (IR 82.7 of 100,000 population with 9 deaths (CFR 1%). Larva-free number (ABJ) Â in Sleman Regency was 91.79%, below standard 95%. But the incidence of DHF was decreased. The general objective of study was determined the relationship between ABJ with the Incidence Rate of DHF in Sleman Regency in2013-2017.Method : The population was the incidence of DHF in Sleman Regency in 2013 - 2017, using secondary data. The independent variable was ABJ and the Incidence Rate of DHF as the dependent variable. Univariate analysis was done to get a decription of ABJ and IR DHF. Bivariate analysis was performed to examine the relationship between ABJ and DHF Incidence Rate. The strength of relationship was obtained by regression and correlation analysis.Result : these results was showed a very low relationship and a positive pattern. A coefficient of determination was closed to zerro, indicated no relationship.Conclusion : between 2013-2017, the Larva-free Numbers in Sleman Regency was fluctuated, in 2016-2017 it was below standard. Incidence Rate in Sleman Regency 2013-2017 was fluctuated, the lowest case occurred in 2017. There was a weak negative relationship between ABJ and IR DHF in Sleman Regency namely 2013-2017, but statistically not meaningful.
THE RELATION BETWEEN RESOURCES AND WASTE BANK PROGRAM WITH THE SUCCES OF WASTE BANK IN YOGYAKARTA
Authors: Arizkyani Agustin , Mulasari Surahma Asti
Published: July 2022

Background : The problem of waste in Indonesia is not only a lack of technical, social, economic and cultural, but covers all aspects of human life. Community-based waste management of which is waste bank program. Implementation of waste bank program will not run smoothly without any quality resources and waste banks a good program. The aim of this study was to determine the relationship between resources and bank program to the success of the bank trash bins in the city of Yogyakarta.Methods : The study is an observational analytic research with cross sectional approach to study design (cross-sectional) is a research to study the dynamics of the relationship between resources and programs with the success of the bank's bank rubbish bins. Data analysis using chi square test.Results : Based on statistical test revealed that there was no relationship between the amount of garbage bank manager with success in the city of Yogyakarta. This is evidenced from the value (P Value 0.092> 0.05). There is no relationship between education and success garbage bank in Yogyakarta. This is evidenced from the value (P Value 0.299> 0.05). There is no relationship between program success bank banks bins with garbage in the city of Yogyakarta. This is evidenced from the value (P Value 0.665> 0.05). There is no relationship between the bank operational schedule of garbage with garbage bank's success in the city of Yogyakarta. This is evidenced from the value (P Value 0.222> 0.05).Conclusion : This study concluded that there was no correlation between the resources and programs with success bank bank rubbish bins in the city of Yogyakarta.
HUBUNGAN ANTARA MODAL SOSIAL DENGAN PELAKSANAAN GERAKAN SATU RUMAH SATU JUMANTIK DI DUSUN MEJING LOR AMBARKETAWANG GAMPING SLEMAN
Authors: Sukesi Tri Wahyuni , Januarti Arkana
Published: July 2022

Background : Dengue Hemorrhagic Fever (DHF) is still the main problem in Indonesia. Dengue disease control is to create individuals and communities who are independent in preventing and protecting themselves from dengue transmission through the optimization of 3M Plus PSN activities in addition to increasing public access to quality health services. One of the Dengue Control Missions is to promote aspects of empowerment and community participation as well as multi-sector partnerships.Community empowerment in controlling DHF requires strong social capital to be able to foster mutual.t rust in cooperation, participation, mutual trust and prevailing normsMosquito breeding activities must be carried out in every house, public place and institution by the larvae monitor (Jumantik). To get optimal results, the Jumantik must be formed starting from each house by designating one of the family members as the jumantik (Gerakan 1 Rumah 1 Jumantik)Method : This research is an analytic observational research with crossectional research design that is studying the dynamics of the correlation between risk factors between social capital independent variables with the dependent variable in this study the implementation of Gerakan Satu Rumah Satu Jumantik. The population in this study entire houses in Mejing Lor Ambarketawang Gamping Sleman. Samples were taken using total sampling technique in which samples using secondary data. Data was analysed with uji chi square of Software Statistic.Result : Based on the research that has been done, the correlation coefficient between social capital and the implementation Gerakan Satu Rumah Satu Jumantik is obtained, with the significance value on the results showing (p = 0,000 <0.05) which indicates a correlation. between social capital and the implementation of Gerakan Satu Rumah Satu Jumantik in the Mejing Lor Village, Ambarketawang Gamping. While the analysis obtained RP 5.406 > 1 with Confident Interval (2.716 -10.752) which means that respondents with bad social capital are more likely to implement the Gerakan Satu Rumah Satu Jumantik in the Mejing Lor Village, Ambarketawang Gamping is not good..Conclusions :There is a Correlation between Social Capital and the Implementation Gerakan Satu Rumah Satu Jumantik in the Mejing Lor Village, Ambarketawang Gamping
Eğitim Fakülteleri Yönetiminde Kadın Temsilinin İncelenmesi
Authors: TERZİ Gülçin , DENİZ Levent
Published: July 2022

Bu çalışmanın amacı gelecek nesilleri şekillendirecek öğretmenleri yetiştiren eğitim fakültelerinin yönetim kademelerindeki cinsiyet dağılımının genel tarama modeli kullanılarak incelenmesidir. Bu kapsamda Yükseköğretim Bilgi Yönetim Sistemi birim istatistikleri taranarak devlet üniversitelerinin bilgilerine ulaşılmıştır. Ulaşılan 80 eğitim fakültesinin (77 eğitim fakültesi ve üç eğitim bilimleri fakültesi) dekan, dekan yardımcısı, bölüm başkanı, ana bilim dalı başkanı bilgileri betimsel olarak analiz edilmiştir. Çalışmadan elde edilen bulgular, erkek dekan oranının kadın dekan oranından yaklaşık beş kat, erkek dekan yardımcıları oranının kadın dekan yardımcıları oranından ise 2.5 kat fazla olduğunu göstermektedir. Buradan hareketle eğitim fakültelerinin üst yönetim kadrolarında kadın akademisyenlerin varlığının göze çarpan bir oranla azınlıkta kaldığı, orta seviye yönetim kadrolarında da durumun pek de iyimser olmadığı görülmektedir. Çalışmadan elde edilen diğer bir bulgu ise özellikle Türkçe ve Sosyal Bilimler Eğitimi, Matematik ve Fen Bilimleri Eğitimi ile Bilgisayar ve Öğretim Teknolojileri Eğitimi bölümlerinde kadınların yönetim pozisyonlarındaki sınırlı temsilidir. Çalışmanın son bölümünde akademik yönetimde kadın temsilinin iyileştirebilmesi için çeşitli öneriler sunulmuştur.
A Study on Improvement of the Military IdAM Using Edge-Sovereign Identity (ESI)
Authors: Park Gyudong , Jeon Gi-Yoon , Kim Jong-Oh
Published: July 2022

A framework-level IdAM integration approach requires a stable network infrastructure. Information framework’s operation may be significantly restricted when the network is disconnected from the remote IdAM service. Moreover, military networks, especially tactical networks, are volatile, and network disconnection is also high. In this paper, we proposed an Edge-Sovereign Identity (ESI) that expanded the concept of SSI for use in the military field, designed the structure and function of the proposed concept, and demonstrated its usefulness and validity through examples and prototypes.
Neural responses in human superior temporal cortex support coding of voice representations
Authors: Rupp Kyle , Hect Jasmine L. , Remick Madison , Ghuman Avniel , Chandrasekaran Bharath , Holt Lori L. , Abel Taylor J.
Published: July 2022

The ability to recognize abstract features of voice during auditory perception is an intricate feat of human audition. For the listener, this occurs in near-automatic fashion to seamlessly extract complex cues from a highly variable auditory signal. Voice perception depends on specialized regions of auditory cortex, including superior temporal gyrus (STG) and superior temporal sulcus (STS). However, the nature of voice encoding at the cortical level remains poorly understood. We leverage intracerebral recordings across human auditory cortex during presentation of voice and nonvoice acoustic stimuli to examine voice encoding at the cortical level in 8 patient-participants undergoing epilepsy surgery evaluation. We show that voice selectivity increases along the auditory hierarchy from supratemporal plane (STP) to the STG and STS. Results show accurate decoding of vocalizations from human auditory cortical activity even in the complete absence of linguistic content. These findings show an early, less-selective temporal window of neural activity in the STG and STS followed by a sustained, strongly voice-selective window. Encoding models demonstrate divergence in the encoding of acoustic features along the auditory hierarchy, wherein STG/STS responses are best explained by voice category and acoustics, as opposed to acoustic features of voice stimuli alone. This is in contrast to neural activity recorded from STP, in which responses were accounted for by acoustic features. These findings support a model of voice perception that engages categorical encoding mechanisms within STG and STS to facilitate feature extraction.