bluuebunny/crossref_metadata_2025 huggingface dataset:
Estetika Manajemen Melatih Hatha Yoga
Authors: Yoga Pramana Ida Bagus Kade , Sintia Ni Kadek , Rudiarta I Wayan
Published: May 2024

Hatha Yoga merupakan suatu proses mengolah energi dalam mencapai keseimbangan dan kesempurnaan fisik, psikis dan emosional. Hatha Yoga mengandung nilai Estetika Hindu yang mencakup nilai kebenaran (satyam), kesucian (sivam), dan keindahan (sundaram). Konsep ini berperan dalam praktik Hatha Yoga dengan meningkatkan pemahaman diri, mengembangkan kebajikan, dan mencapai keindahan dalam harmoni fisik dan mental. Sehingga penulis tertarik untuk mengkaji terkait estetika manajemen melatih Hatha Yoga. Penelitian ini menggunakan pendekatan kajian pustaka dan kualitatif deskriptif untuk menganalisis data. Data diperoleh melalui observasi langsung, wawancara terstruktur, dan studi dokumentasi. Langkah-langkah analisis melibatkan data reduction, data display, dan conclusion drawing/verification. Kemudian hasilnya diinterpretasi sesuai kebutuhan dan kedalaman kajian. Bagi seorang instruktur yoga, manajemen melatih merupakan hal penting untuk membimbing peserta mencapai tujuan dan harapan. Proses manajemen melibatkan perencanaan, pelaksanaan, dan evaluasi. Estetika, manajemen melatih Hatha Yoga mencakup penciptaan suasana yang nyaman, pemilihan waktu dan tempat yang tepat, serta penggunaan musik yang sesuai. Selain itu, estetika dalam praktik yoga mencerminkan harmoni antara tubuh, pikiran, dan jiwa, serta keindahan dalam gerakan dan pose. Estetika manajemen melatih Hatha Yoga membantu mencapai manfaat positif bagi kesehatan fisik dan mental, serta mencapai keseimbangan dan kesejahteraan holistik.
STT Candra Metu Organization Communication In Building Menyama Braya Ties at Banjar Budamanis Sidemen Karangasem
Authors: I Kadek Indra  , Ulio  , Yuliani Ni Made
Published: May 2024

STT Candra Metu is a youth organization in Budamanis Banjar, Tabola Traditional Village, Sidemen Village, Sidemen District, Karangasem Regency which is engaged in social activities, one of which is building bonds of mutual help between people, namely manyama braya. An organizational communication strategy is urgently needed in building manyama braya ties in Banjar Budamanis so that an active organization is created.
This study raises three main issues, namely : What are the forms of manyama braya activities, Organizational Communication Strategies used and what are the implications of STT Candra Metu's Activities in building the manyama braya bond in Banjar Budamanis, Tabola Traditional Village, Sidemen Karangasem? This study uses a qualitative descriptive approach and uses three theories, namely fusion theory, attribution and structural functional theory. Data collection methods used include observation, interviews, documentation and literature. All data is processed using qualitative descriptive techniques.
The results of this study indicate that the activities carried out by STT Candra Metu in building the manyama braya bond consist of activities in supporting the implementation of the yadnya ceremony, as a forum for strengthening intimate relationships and channeling creativity, interests and talents. While the communication strategy includes: Vertical communication consisting of bottom-up, top-down and horizontal communication. And the implications of STT Candra Metu in building manyama braya bonds include: Sociol cultural and economic implications for society. Based on this research, it can be concluded that an organizational communication strategy is needed to establish and move the wheels of the organization in building manyama braya ties between fellow STT Candra Metu.
IKLIM KOMUNIKASI ORGANISASI DALAM MENINGKATKAN KINERJA KARYAWAN GORES DIGITAL
Authors: Mirna Wati Dewa Ayu , Suniantara I Ketut Putu
Published: May 2024

Iklim komunikasi organisasi merupakan gabungan persepsi mengenai peristiwa komunikasi, perilaku komunikasi, respon pegawai terhadap pegawai lain, harapan, konflik antarpribadi dan peluang pertumbuhan dalam organisasi. Pentingnya keberadaan iklim komunikasi membuat Kompelmen, Brief dan Guzoo membuat hipotesis yang menyatakan bahwa perubahan iklim komunikasi suatu organisasi dapat mempengaruhi kinerja dan produktivitas karyawan. Gores Digital merupakan perusahaan start-up yang bergerak di bidang teknologi percetakan (Printech) yang membantu menyelesaikan permasalahan pelanggan yang menginginkan proses pencetakan yang cepat, mudah dan efisien. Gores Digital sebagai sebuah perusahaan harus mempunyai iklim komunikasi organisasi yang baik. Dengan iklim komunikasi yang baik, karyawan Gores Digital dapat menyelesaikannya dengan baik. Perubahan iklim komunikasi organisasi nantinya akan mempengaruhi produktivitas atau kinerja pegawai karena ukuran kinerja pegawai menjadi fokus utama dalam mencapai tujuan perusahaan. Metode penelitian yang digunakan adalah metode kualitatif. Tujuan penelitian ini adalah untuk mengetahui apakah terdapat pengaruh iklim komunikasi organisasi terhadap kinerja karyawan Gores Digital
Makala-Kalaan Old Tradition in Suter Village, Kintamani District, Bangli Regency
Authors: I Wayan Yudhasatya Dharma  , Armini Ni Wayan Yusi
Published: May 2024

Education is an effort to improve the quality of human life which essentially aims to humanize humans, mature them and change behavior for the better. Education does not only take place at school, but the environment also takes part in this. The environment is the unity of space with all objects, forces, conditions and living creatures, including humans and their behavior, which influence the lives and welfare of humans and other living creatures. In this social environment, a child begins to socialize with the wider community and begins to become familiar with social norms. Culture is also a system of knowledge and also as ideas that a society has. In relation to culture which actually contains elements of education, there is a tradition called Makala-kalaan Tua which is part of the social life of the community in Suter Village, Kintamani District, Bangli Regency. Through this research, researchers want to analyze the implementation of the Makala-kalaan Tua tradition in terms of educational philosophy. To explain the problem above, the author uses qualitative research. In this case, the author was directly involved in collecting data by means of observation, documentation and interviews with informants in Suter Village. Apart from that, this research uses types of library data such as books, journals, or previously existing scientific works that have a correlation with the research being carried out. To answer the problem, researchers used Constructivism Theory. From the research conducted, findings were obtained, namely that the implementation of the Makala-kalaan Tua tradition in Suter Village, Kintamani District, Bangli Regency in terms of educational philosophy contains elements of activeness, creativity and innovation. Where these three elements constitute the true essence of education. Because in an educational process, activeness is very important because it influences the results of the education itself. Then creativity and innovation are the goals to be achieved in every educational process.
O Serviço Público e suas novas crises
Authors: Nobrega Theresa
Published: May 2024

The notion of public service for Brazilian administrative law has always been endowed with a natural fog, which involves dogmatic discussion based on the uncertainties of the elements and the scope of the concept, extending into spaces where new execution models continue to foster doubt. The debate on the distinction between public service and economic activity is once again on the agenda of administrative law, as the economic crisis influences adjustments aimed at the privatization of state-owned companies such as the Brazilian postal and telegraph company and the Rio water and sanitation company of January. In the reflections set out in this essay, we propose premises to face the “new crises” of public service, elucidating issues that compromise the efficiency of the State's administrative function, in points relating to its universality and adequacy. It is an invitation to doubt and conjecture many answers to the same question. What are the risks of Brazilian public service?
Imparcialidade dos árbitros:
Authors: Maia Alberto Jonathas
Published: May 2024

O presente artigo trata sobre a imparcialidade do árbitro a partir de uma interseccional buscando subsídios no direito processual, economia e psicologia. A imparcialidade pode ser analisada em seus diversos desdobramentos (estética, subjetiva multidirecional, objetiva, valorativo-probatória e normativa). O tema tem sido objeto de intensos debates no meio acadêmico e judicial e, por meio desse estudo, pretende-se contribui para o debate demonstrando que o árbitro deve estar comprometido em um esforço contínuo e permanente para preservar e cultivar a imparcialidade.
Clinical outcomes of primary anterior cruciate ligament reconstruction using six-strand hamstring autograft
Authors: Shah Nisarg , Dodiya Hardik , Damor Rohit , Pachore Javahir
Published: May 2024

Objectives:

Quadrupled and five-strand hamstring tendon (HT) autografts are commonly used in anterior cruciate ligament reconstruction (ACLR), but there is significant variability in graft diameter. The six-strand HT autograft has been introduced to increase graft diameter in patients with undersized HT grafts and may achieve better clinical outcomes. None of the studies has reported clinical outcomes following this technique in Indian patients. We investigated clinical outcomes in patients who underwent primary ACLR using a six-strand HT autograft technique with a minimum six-month follow-up.

Materials and Methods:

Fifty-five patients who underwent primary ACLR using six-strand HT autografts with interference screw fixation were included in the study. These patients were followed up at three and six months for the evaluation of clinical outcomes. Subjective evaluations included the TegnerLysholm score, anterior cruciate ligament-quality-of-life (ACL-QOL) score, and International Knee Documentation Committee (IKDC) subjective score. Laxity assessments of the knees were performed using the Lachman test and the pivot-shift test. Functional evaluation of the patients was performed with an overall IKDC objective score.

Results:

The mean IKDC subjective score was significantly improved at three-month (63.42 ± 5.38) and six-month (82.82 ± 7.49) follow-up after surgery (P < 0.05) when compared with pre-operative scores (50.55 ± 1.84). A similar finding was also noted with the Tegner-Lysholm score and ACL-QOL score in our study. All patients have achieved normal to near-normal functional outcomes at six months in our study without any major complications. The most commonly found complication was paresthesia (21.80%) in the present study.

Conclusion:

In the primary ACLR, six-strand hamstring autograft achieves similar clinical outcomes and complications as reported with four-strand or five-strand HT autografts. However, the percentages of patients who achieved normal to near-normal outcomes were higher in the present study (100%) as compared to earlier reported data using four-strand or five-strand HT autografts (~85%). The six-strand graft technique is a useful means of increasing graft diameter when faced with an undersized hamstring graft.
Acute hyponatremia post craniotomy resulting in a unilateral fixed and dilated pupil: A case study on diagnosis and management
Authors: Caldwell David J. , Scheer Justin K. , Umbach Gray , Aghi Manish K.
Published: May 2024

Background:

Postoperative hyponatremia is a known complication of intracranial surgery, which can present with depressed mental status. Hyponatremia resulting in focal neurologic deficits is less frequently described.

Case Description:

We describe a patient who, after a bifrontal craniotomy for olfactory groove meningioma, developed acute hyponatremia overnight with a decline in mental status from Glasgow coma scale (GCS) score 15 to GCS 7 and a unilateral fixed dilated pupil. Head computed tomography showed expected postoperative changes without new acute or localizing findings, such as unilateral uncal herniation. The patient’s mental status and pupil immediately improved with the administration of mannitol; however, there was a subsequent decline in mental status with a preserved pupil later that morning. Hypertonic saline reversed the neurologic change, and the patient was eventually discharged without a neurologic deficit. Focal neurologic deficits need not always arise following a craniotomy from a postoperative hematoma, stroke, or other finding with radiographic correlate.

Conclusion:

Post-craniotomy hyponatremia should now be seen as a postoperative complication that can result in both a general neurologic decline in mental status, as well as with focal neurologic signs such as a fixed, dilated pupil, which can be reversed with hyperosmolar therapy and correction of the hyponatremia.
Tortugas dulceacuícolas de la Reserva Ecológica Ciudad Universitaria-Costanera Norte, Buenos Aires, Argentina
Authors: Pan Martínez Julieta , Courtalon Paula
Published: May 2024

Este trabajo busca corroborar la presencia de tortugas dulceacuícolas en la Reserva Ecológica Ciudad Universitaria-Costanera Norte, evaluar si existen variaciones mensuales en la abundancia relativa de alguna de las especies observadas y estudiar su comportamiento y uso del hábitat. Se realizaron avistajes semanales desde octubre de 2022 a junio de 2023, en cuatro puntos del humedal (HI1, HI2, HI3 y HC), entre 12:00 y las 16:00 h. Las tortugas observadas fueron identificadas y su comportamiento se clasificó en asoleamiento, desplazamiento y alimentación. Las variaciones en la abundancia relativa se analizaron por sitio mediante una prueba de Kruskal-Wallis, utilizando contrastes a posteriori de Benjamini-Hochberg si se encontraban diferencias entre meses. Detectamos la presencia de Phrynops hilarii, Trachemys dorbigni e Hydromedusa tectifera, siendo P. hilarii la única especie abundante y frecuente. No encontramos diferencias en la abundancia relativa de P. hilarii entre meses para HI2 (χ2=13.78; P=0.088) y HI3 (χ2=7.28; P=0.507), pero sí una mayor abundancia relativa en diciembre con respecto a mayo (z=-3.17; P.adj=0.028) y abril (z=-3.17; P.adj=0.028) en HI1, y en octubre en relación con noviembre (z=-2.99; P.adj=0.017), diciembre (z=-2.99; P.adj=0.017), enero (z=-2.99; P.adj=0.017), febrero (z=-2.99; P.adj=0.017), marzo (z=-2.99; P.adj=0.017) y junio (z=-2.99; P.adj=0.017) para HC. Los comportamientos de asoleamiento y desplazamiento se observaron en los cuatro puntos, mientras que la alimentación, solo en HI2 y HI3. Definimos áreas de asoleamiento en HI1 y HIC, asoleamiento y alimentación en HI2 y HI3, y tránsito en HI1, HI2 y HI3. Proponemos medidas de manejo para garantizar la conservación de las tortugas en la reserva.
The Chemistry of the Defensive Secretions of three species of millipedes in the genus Brachycybe
Authors: Banks Paige , Funkhouser Emma M. , Macias Angie M. , Lovett Brian , Meador Shelby , Hatch Arden , Garraffo H. Martin , Cartwright Kaitie C. , Marek Paul , Kasson Matt T. , Jones Tappey H. , Mevers Emily
Published: May 2024

Millipedes have long been known to produce a diverse array of chemical defense agents that deter predation. These compounds, or their precursors, are stored in high concentration within glands (ozadenes) and are released upon disturbance. The subterclass Colobognatha contains four orders of millipedes, all of which are known to produce terpenoid alkaloids—spare the Siphonophorida that produce terpenes. Although these compounds represent some of the most structurally-intriguing millipede-derived natural products, they are the least studied class of millipede defensive secretions. Here, we describe the chemistry of millipede defensive secretions from three species of Brachycybe: Brachycybe producta, Brachycybe petasata, and Brachycybe rosea. Chemical investigations using mass spectrometry-based metabolomics, chemical synthesis, and 2D NMR led to the identification of five alkaloids, three of which are new to the literature. All identified compounds are monoterpene alkaloids with the new compounds representing indolizidine (i.e. hydrogosodesmine) and quinolizidine alkaloids (i.e. homogosodesmine and homo-hydrogosodesmine). The chemical diversity of these compounds tracks the known species phylogeny of this genus, rather than the species geographical proximity. The indolizidines and quinolizidines are produced by non-sympatric sister species, B. producta and B. petasata, while deoxybuzonamine is produced by another set of non-sympatric sister species B. rosea and Brachycybe lecontii. The fidelity between the chemical diversity and phylogeny strongly suggests that millipedes generate these complex defensive agents de novo and begins to provide insights into the evolution of their biochemical pathways.
Computational Catalysis and Machine Learning Applications to Water Treatment Technologies
Authors: Wang Duo , Xie Ao , Ma Shengcun , Tong Wei , Zou Shiqiang , Jain Anubhav
Published: May 2024

Electrocatalysis can offer new routes to water treatment. For example, electrocatalytic reduction is an emerging technology for treating oxyanions of concern in water. However, identification of highly performant, cost-effective catalysts remains a major barrier to deployment at scale. This article discusses how computational modeling and machine learning can accelerate the search for new catalyst materials. It describes how traditional computational chemistry workflows, now deployed in their basic form for at least two decades, can be expanded in breadth and depth through newly developed machine-learned force fields that have been trained on millions of examples. It also discusses how the theory and machine learning pipeline can effectively integrate with experimental synthesis and characterization platforms to rapidly identify and validate new catalyst chemistries.
Discovery of Biofilm Inhibitors from the Microbiota of Marine Egg Masses
Authors: Kyei Lois , Piedl Karla , Menegatti Carla , Miller Eleanor M. , Mevers Emily
Published: May 2024

Biofilms commonly develop in immunocompromised patients, which leads to persistent infections that are difficult to treat. In the biofilm state, bacteria are protected against both antibiotics and the host’s immune system; currently, there are no therapeutics that target biofilms. In this study, we screened a chemical fraction library representing the natural product capacity of the microbiota of marine egg masses, namely, the moon snail egg collars. This led to the identification of active fractions targeting both Pseudomonas aeruginosa and Staphylococcus aureus biofilms. Subsequent analysis revealed that a subset of these fractions were capable of eradicating pre-formed biofilms, all against S. aureus. Bioassay-guided isolations led to identifying pseudochelin A, a known siderophore, as a S. aureus biofilm inhibitor with an IC50 of 34.1 μg/mL. Mass spectrometry-based metabolomic analyses revealed widespread production of pseudochelin A among fractions possessing S. aureus antibiofilm properties. In addition, a key biosynthetic gene involved in producing pseudochelin A was detected on 30% of the moon snail egg collars and pseudochelin A is capable of inhibiting the formation of biofilms (IC50 19.5 μg/mL) produced by ecologically relevant bacterial strains. All suggesting that pseudochelin A may have a role in shaping the microbiome or protecting the egg collars from microbiofouling.
Illuminating Disorder: Optical Properties of Complex Plasmonic Assemblies
Authors: Sherman Zachary M. , Kang Jiho , Milliron Delia J. , Truskett Thomas M.
Published: May 2024

The optical properties of disordered plasmonic nanoparticle assemblies can be continuously tuned through the structural organization and composition of their colloidal building blocks. However, progress in the design and experimental realization of these materials has been limited by challenges associated with controlling and characterizing disordered assemblies and predicting their optical properties. This perspective discusses integrated studies of experimental assembly of disordered optical materials, such as doped metal oxide nanocrystal gels and metasurfaces, with electromagnetic computations on large-scale simulated structures. The simulations prove vital for connecting experimental parameters to disordered structural motifs and optical properties, revealing structure-property relations that inform design choices. Opportunities are identified for optimizing optical property designs for disordered materials using computational inverse methods and tools from machine learning.
Bioorthogonal Polymerization of Coiled-Coil Peptides
Authors: Gao Hanyuan , Zhang Tianren , Langenstein Matthew , Xie Weiran , Udan Samiksha , Zhang Zihan , Saven Jeffery , Bai Shi , Pochan Darrin , Fox Joseph , Jia Xinqiao
Published: May 2024

Peptides capable of forming homotetrameric coiled-coil bundles are utilized as the monomeric building blocks (“bundlemers”) to synthesize hybrid polymers consisting of covalently linked coiled-coil microdomains with regularly spaced ethylene glycol repeats via tetrazine ligation with trans-cyclooctene. We confirm the formation of long, semiflexible rods with a Kuhn length of 6 - 7 nm and a molecular weight of 100 - 3,000 kDa. Polymerization at tetrazine concentrations > 5 mM results in the formation of mechanically robust hydrogels with defined viscoelastic properties through chain entanglements. Copolymerization of coiled-coil peptides with distinct composition and thermal stability gives rise to hydrogels that are thermally tractable. Solid-to-fluid transition occurs when one of the coiled-coil repeats melts. Upon cooling, solid-like properties are partially recovered through intermolecular association of the helical peptides. Overall, tetrazine ligation has enabled the covalent polymerization of self-assembled coiled-coil motifs for the establishment of protein-like linear polymers with unprecedent molecular weight.
Truncations and in silico Docking to Enhance the Analytical Response of Aptamer-Based Biosensors
Authors: Nguyen Minh-Dat , Osborne Meghan , Prevot Guy Terence , Churcher Zachary , Johnson Philip , Simine Lena , Dauphin Ducharme Philippe
Published: May 2024

Aptamers are short oligonucleotides capable of binding specifically to various targets (i.e., small molecules, proteins, and whole cells) which have been introduced in biosensors such as in the electrochemical aptamer-based (E-AB) sensing platform. E-AB sensors are comprised of a redox-reporter-modified aptamer attached to an electrode that undergoes, upon target addition, a binding-induced change in electron transfer rates. To date, E-AB sensors have faced a limitation in the translatability of aptamers into the sensing platform presumably because sequences obtained from Systematic Evolution of Ligands by Exponential Enrichment (SELEX) are typically long (> 80 nucleotides) and that obtaining structural information remains time and resource consuming. In response, we explore the utility of aptamer base truncations and in silico docking to improve their translatability into E-AB sensors. Here, we first apply this to the glucose aptamer, which we characterize in solution using NMR methods to guide design and translate truncated variants in E-AB biosensors. We further investigated applicability of the truncation and computational approaches to five other aptamer systems (vancomycin, cocaine, methotrexate, theophylline, and ochratoxin A) from which we derived functional E-AB sensors. We foresee that our strategy will increase the success rate of translating aptamers into sensing platforms to afford low-cost measurements of molecules directly in undiluted complex matrices.
Radical-Mediated Regiodivergent C(sp3)–H Functionalization of N-Substituted Indolines via Enzymatic Carbene Transfer
Authors: Couture Bo , Cui Ru , Chu Jia-Min , Zhang Yong , Fasan Rudi
Published: May 2024

Indolines are ubiquitous structural motifs found in pharmaceuticals and natural products but modification of these scaffolds via selective C(sp3)–H functionalization represents a major challenge. Herein, we report the regio- and stereoselective C(sp3)–H functionalization of N-substituted indolines to produce both -and-functionalized indolines via carbene transfer chemistry with engineered iron-based CYP119 catalysts. These transformations are shown to proceed with high regio- (up to >99%) and enantioselectivity (up to 98% e.e.) as well as excellent catalytic efficiency (up to 99% yield and 8,900 TON), furnishing an efficient and regiodivergent route for diversification of this class of medicinally relevant molecules via direct C(sp3)–H functionalization. We further show that these catalysts can enable selective functionalization of exocyclic C(sp3)–H bond in N-methyl indolines and that enzyme-mediated a-and b-C(sp3)–H functionalization can be combined in a biocatalytic cascade to yield polycyclic indoline-containing scaffolds, which can be found in many drugs. Finally, computational and experimental mechanistic studies provide evidence for the occurrence of a radical-mediated C–H functionalization pathway, providing first insights into the mechanism of P450-catalyzed C(sp3)–H carbene insertion. Altogether, this work provides a direct and tunable strategy for the synthesis of functionalized indolines as key building blocks for medicinal chemistry and natural product synthesis and it sheds light into the mechanism of P450-catalyzed C(sp3)–H functionalization via carbene transfer.
A evolução dos vestibulares da UnB 90/96. : física
Authors: Pôrto Cleovan
Published: May 2024

As transformações por que passa o ensino médio no Distrito Federal com relação à implantação do ensino significativo, introduzido pela UnB, já se fizeram sentir em sala de aula, com a constante procura de aperfeiçoamento por parte dos professores, no que diz respeito à busca de informações para acompanhar as mudanças exigidas pela sociedade. Com isso, este trabalho propõe uma contribuição no sentido de prover o estudante do 2Q grau do uso da reflexão sobre a memorização na resolução de questões e de provas. Dessa forma, a física pode caminhar na dianteira do progresso científico aliada às propostas de reformulação, com acerto, do ensino médio.
Oropharyngeal Candidiasis, Candida Albicans Infections, and Oral Immune Mediators Associated with Oral Human Immunodeficiency Virus: A Literature Review
Authors: King Cameron B.R.
Published: May 2024

Introduction: While Candida albicans are usually commensal and present in low density in the oral cavity of healthy individuals, an immunocompromised immune system can lead to the overgrowth of this fungal species, leading to oral microbiome “dysbiosis” and activation of immune responses. In severe cases, C. albicans overgrowth can lead to an oral infection called oropharyngeal candidiasis (OPC), which is associated with inflammation, lesions, and sores of the oral cavity. While human immunodeficiency virus (HIV) infection has been linked to an increased risk of OPC, few studies have associated OPC and C. albicans infection with subsequent risk for oral HIV acquisition. Evidence on the oral microbiome and how it can alter HIV risk is also lacking. Methods: A literature search was performed on PubMed, Google Scholar, and the University of Alberta Library Database from inception to November 2023. Results and Discussion: The risk of oral HIV transmission is low. OPC and C. albicans fungal infection can increase HIV susceptibility by activating immune responses associated with the clearance of microbial pathogens, inducing inflammation and elevations in cytokines related to HIV risk including IL-17, IL-6 and IL-1ß. Persistent C. albicans infections also promote the recruitment of T-helper 17 cells, which is a common HIV target cell, and neutrophils, which releases neutrophil proteases upon inflammation and mediates the cleavage of tight junction proteins, ultimately disrupting the oral microbiome. Conclusion: Increased immune cell recruitment to the mucosa and increased epithelial breakdown may facilitate the diffusion and access of HIV virions across the epithelium to immune target cells, suggesting that OPC and C.albicans infections has the potential to increase risk for oral HIV acquisition. Limited evidence of the relationship between C. albicans density, OPC, and oral HIV risk, warrants high-quality cross-sectional studies in the future.
The Association of Mercury and ALT with Obesity in Korean Adults Using Data from the Korea National Health and Nutrition Examination Survey for 11 Years (KNHANES 2005, 2008–2017)
Authors: Pyo Sang Shin
Published: May 2024

The association between heavy metals in the blood and obesity has been examined in many studies. However, inconsistencies have been observed in the results of these studies. The present study was conducted using data from 119,181 participants of the Korea National Health and Nutrition Examination Survey (KNHANES) for 11 years in 2005 and between 2008 and 2017. The subjects with missing heavy metal blood tests, health interview data, and health examination data were excluded from the study. The study population comprised 1,844 individuals (972 men, and 872 women) who were eligible for inclusion. It was found that obesity and abdominal obesity were associated with an increase in both blood mercury (P < 0.001) and alanine aminotransferase (ALT) (P < 0.001). After adjusting the confounding factors, those with concurrent high levels of ALT and the highest tertile of mercury showed an increased risk of obesity (odds ratio 4.46, 95% confidence interval 2.23–8.90, P < 0.001) as well as abdominal obesity (odds ratio 5.36, 95% confidence interval 2.57–11.17, P < 0.001). The interrelationship of mercury and ALT with the parameters of body mass index (P for interaction = 0.009) and waist circumference (P for interaction = 0.012), respectively, have been observed to be significant, suggesting that the reciprocal relationship could contribute to obesity and abdominal obesity.
Effect of PDCA on Nursing Management
Authors: Yao Jinqin , Xian Xiaoyun
Published: May 2024

Objective: To explore and analyze the effect of the plan-do-check-act (PDCA) cycle method in the nursing management of head nurses. Methods: 68 patients who were hospitalized in the general surgery department were used as research subjects. The patients were divided into an experimental group and a reference group, with 34 cases in each group, by drawing lots. The experimental group was managed with the PDCA method. The management satisfaction, nursing quality score, and nursing effect of both groups were compared with each other. Results: The patients in the experimental group were generally more satisfied with the nursing services compared to the reference group (P < 0.05), and the difference was statistically significant. Before the intervention, there was no statistically significant difference (P > 0.05) in the nursing quality scores such as ward safety management, nursing risk management, nursing document writing, rescue equipment management, and head nurse administrative management between the two groups. After the intervention, the experimental group had higher nursing quality scores. Furthermore, the nursing effects such as disease education, quality control, safety management, humanistic care, and service attitude in the experimental group were significantly better than those in the reference group (P < 0.05). Conclusion: The application of the PDCA method in nursing management can improve management satisfaction, nursing quality, and nursing effect.
The Effect of Nebulized Budesonide Inhalation in Treating Children with Asthma and its Influence on Immune Indexes
Authors: Hua Qin
Published: May 2024

Objective: To explore and analyze the effect of nebulized budesonide inhalation on children with asthma and its influence on immune indexes. Methods: 300 children who were with asthma admitted to the Pediatric Respiratory Department of our hospital from January 2021 to January 2023 were selected as the research subjects. The patients were divided into a nebulization group (n = 150) and a reference group (n = 150) by drawing lots. The nebulization group received routine treatment along with budesonide nebulization inhalation therapy, while the reference group only received routine treatment. The treatment effect, the immune indicators, the time taken for the disappearance of symptoms, and the pulmonary function indicators of both groups were compared. Results: The total efficacy of treatment received in the nebulization group was significantly higher than that in the reference group (P < 0.05). Before treatment, there was no statistically significant difference in the CD4+, CD8+, CD4+/CD8+, between the two groups (P > 0.05); after treatment, the nebulization group’s CD4+, CD8+, CD4+/CD8+ and other immune indicators were significantly better than the reference group (P < 0.05). The time taken for the disappearance of symptoms like wheezing, coughing, crackles, shortness of breath, and other symptoms in the nebulization group was significantly shorter than in the reference group (P < 0.05). Before treatment, there was no statistically significant difference in the pulmonary function indexes such as FEV1, PEF, and FVC between the two groups (P > 0.05); after treatment, the pulmonary function indexes of the patients in the nebulization group were significantly better than those in the reference group (P < 0.05). Conclusion: Nebulized budesonide inhalation therapy has shown significant efficacy in the treatment of pediatric asthma, with notable improvements in immune indicators. Therefore, it is worthy of recommendation and further promotion
Analysis of the Application Effect of Extended Care Combined with Family Health Education in The Treatment of Pediatric Eczema
Authors: Liu Mailan
Published: May 2024

Objective: To analyze the application effect of continuity of care combined with family health education in the treatment of pediatric eczema. Methods: Sixty cases of pediatric eczema children who were admitted from January 2021 to December 2023 were selected and divided into two groups of 30 cases each. The control group received routine care and the observation group received continuation of care combined with family health education. Family knowledge, eczema basic receding time, family satisfaction, and recurrence rate between the two groups were compared. Results: The aftercare family knowledge mastery score and family satisfaction of the observation group were higher than the control group, where eczema basic receding time and recurrence rate in six months were lower in the observation group as compared to the control group (P < 0.05). Conclusion: In the treatment of pediatric eczema, continuity of care combined with family health education improved the family’s awareness of the disease, controlled eczema symptoms, and reduced the recurrence rate.
Rehabilitasi Lahan Kritis Melalui Penerapan Four-Dimensional Agroforestry di Tenjolaya, Bogor, Jawa Barat
Authors: Hartoyo Adisti Permatasari Putri , Madani Hilmi Naufal , Muhammad Dimas Nur , Hasanah Asmaul , Ghalib Ammar , Alifioni Kintan
Published: May 2024

Lahan kritis diakibatkan oleh penggunaan lahan yang tidak berkelanjutan dan berdampak pada menurunnya fungsi ekosistem lahan. Salah satu upaya rehabilitasi lahan kritis yang dapat dilakukan adalah melalui implementasi four-dimensional agroforestry (4D Agroforestry). Tujuan penelitian ini adalah i) merancang desain 4D Agroforestry, dan ii) menganalisis pertumbuhan tanaman jahe (Zingiber officinale), lada (Piper nigrum), kapulaga (Amomum cardamomum), dan cincau (Cyclea barbata Miers) di bawah naungan mahoni (Swietenia mahagony). Jumlah tanaman yang digunakan adalah 67 bibit jahe, 44 bibit lada, 187 bibit cincau, dan 65 bibit kapulaga, sehingga totalnya adalah 363 bibit tanaman dengan durasi pengamatan adalah 4 MST. Implementasi 4D Agroforestry menjadi alternatif upaya optimalisasi pengelolaan lahan dengan memanfaatkan 4 dimensi, yakni i) dimensi length (panjang) dengan penanaman mahoni, ii) dimensi width dengan penanaman cincau (C. barbata), iii) dimensi height (tinggi) dengan penanaman lada (P. nigrum), singkong (M. esculenta), jahe (Z. officinale), dan kapulaga (Amomum cardamomum), serta iv) dimensi time (waktu) untuk produksi jangka pendek (produksi dari tanaman singkong, cincau, jahe, dan kapulaga), menengah (produksi dari tanaman lada), serta panjang (produksi dari kayu mahoni) untuk mencapai produksi berkelanjutan. Tanaman kapulaga menghasilkan pertumbuhan terbaik pada parameter pertambahan tinggi (15,28 cm) dan persen hidup (98.46%) setelah 4 MST.
Kata kunci: agroforestri,  petani, rehabilitasi
Forest and Land Fires Policies Implications in Indonesia: Technological Support Needs
Authors: Syaufina Lailan , Sitanggang Imas Sukaesih , Purwanti Endang Yuni , Rahmawan Hendra , Trisminingsih Rina , Ardiansyah Firman , Wulandari  , Albar Israr , Krisnanto Ferdian , Satyawan Verda Emmelinda
Published: May 2024

The occurrence of forest and land fires in Indonesia has been a critical environmental issue in the South East Asia Region, closely related to the transboundary haze pollution. The government of Indonesia has shifted the fire management paradigm from fire suppression concern to fire prevention priority since 2016. The study aims to systematically review the development of forest and land fire-related policies in Indonesia and to evaluate the use of mobile and web-based applications of The Smart Patrol Information System (SIPP Karhutla) implemented in the Sumatera and Kalimantan regions. We conducted Systematic Literature Reviews to identify the roadmaps of forest and land fire-related policies in Indonesia. Field surveys, questionnaires, and interviews with fire brigades in 7 provinces in the Sumatera and Kalimantan regions to evaluate the use of the SIPP Karhutla. There has been a significant increase of fire-related policies since 2014, which enhance fire management development. The SIPP Karhutla has been widely used in Sumatera and Kalimantan regions. The applications have reduced time for patrol data recording and reporting significantly. Therefore, they supported the fire brigades' patrol activities effectively and efficiently.
Keywords: fire management, Smart Patrol Information System, transboundary haze pollution
Kelayakan Usaha dan Strategi Pengelolaan Agroforestri (Studi Kasus KTH Margo Rukun Ii Provinsi Lampung)
Authors: Resta Muhammad Resta Destyana , Purwawangsa Handian , Pramulya Rahmat
Published: May 2024

Kabupaten Tanggamus memiliki potensi untuk ditanami Multipurpose Tree Species (MPTS) yang dapat memberikan nilai ekonomi dan ekologi terhadap masyarakat. Tujuan penelitian ini yaitu mengidentifikasi pengelolaan HHBK pada lahan agroforestri, menganalisis kelayakan usaha agroforestri, dan merancang strategi pengelolaan usaha agroforestri tingkat Kelompok Tani Hutan (KTH). Pengambilan data dilakukan dengan metode wawancara dan Focus Group Discussion (FGD). Berdasarkan perhitungan analisis finansial yang dilakukan menggunakan metode cost-benefit analysis, usaha dengan pola agroforestri kopi robusta, cabai rawit, alpukat, pisang, lada, kacang merah dan nangka merupakan usaha yang menguntungkan. Usaha agroforestri KTH Margo Rukun II lebih sensitif terhadap penurunan pendapatan daripada kenaikan biaya. Berdasarkan hasil evaluasi analisis faktor internal dan eksternal menggunakan analisis Strength Weakness Opportunity Threat (SWOT), KTH Margo Rukun II berada pada posisi kuadran I (strategi S-O) yang di mana posisi tersebut menunjukkan organisasi memiliki kondisi yang baik untuk melanjutkan usaha.
Kata kunci: Agroforestri, analisis finansial, analisis SWOT, hasil hutan bukan kayu, kelompok tani hutan
ASPECTOS CLÍNICOS DA SÍNDROME DE BROWN-SÉQUARD EM PACIENTES PEDIÁTRICOS: UMA REVISÃO INTEGRATIVA DA LITERATURA
Authors: Adriano Vinicius dos Santos , Silva Luana Negreiros
Published: May 2024

Introdução: A Síndrome de Brown-Séquard (SBS) é um conjunto de sinais e de sintomas relacionados à hemissecção da medula espinhal, tendo o trauma a principal causa, mas pode ser causada por afecções i
CÂNCER DE MAMA NO BRASIL: PERSPECTIVAS DE SAÚDE PÚBLICA NO SÉCULO XXI
Authors: MARINS RENAN AUGUSTO , SANTOS MÁRCIA MÔNICA BORGES DOS , JUNQUEIRA MARINA DA SILVA , SOUSA MIRNA RIBEIRO FREITAS DE , COSTA IACIARA SILVA , GOMES MARIA EDUARDA DUARTE , RIBEIRO KELLY DA SILVA CAVALCANTE , REIS PEDRO FELIPE MENEZES DOS , SANTOS ANGELA DE MELO , FREITAS NUBIA SANTOS
Published: May 2024

Analisar o câncer de mama no Brasil perante as perspectivas de saúde pública no século
XXI. Trata-se de uma ampla revisão de literatura, realizada em 2024 por meio da consulta
às bases de dados BDENF, LILACS e MEDLINE. No século XXI, as perspectivas do
câncer de mama na saúde pública do Brasil envolvem um foco contínuo na
conscientização, prevenção e detecção precoce da doença. A implementação do Programa
Nacional de Controle do Câncer de Mama visa melhorar o acesso ao rastreamento
mamográfico e terapias eficazes. Estratégias direcionadas, como exames clínicos anuais
e mamografias bienais, estão sendo promovidas para diferentes faixas etárias, visando
uma detecção mais precoce. Além disso, é crucial abordar disparidades socioeconômicas
e raciais, melhorar o acesso aos serviços de saúde e adotar abordagens multidisciplinares
para proporcionar um cuidado integral e eficaz às pacientes. A abordagem do câncer de
mama no Brasil demanda uma estratégia ampla que inclua conscientização, acesso
equitativo aos serviços de saúde e avanços terapêuticos, destacando a importância da
atuação da APS e a implementação de filosofias como o Lean Healthcare e a integração
da RAS para melhorar a eficiência e a qualidade do cuidade.
REAÇÕES ADVERSAS DOS ANTI-INFLAMATÓRIOS NÃO ESTEROIDES (AINES) NA FUNÇÃO RENAL
Authors: PACHECO ANDRESSA KELINE FREITAS , BRAGA AMANDA MARIA MENDES , REIS AMANDA TISSORE FORWILLE , ARAÚJO JUAN LUCAS PEREIRA , NASCIMENTO NATHALIA OLIVEIRA DO , BRAGA MELISSA GOMES ANDRADE DE MENEZES , ARAÚJO ÁRLON WENDEL MARINHO DA SILVA , LIMA ALESSANDRA DA SILVA , CARVALHO CLARA VITÓRIA CAVALCANTE , CARVALHO LARISSA HELENA BALDEZ
Published: May 2024

Avaliar as reações dos anti-inflamatórios não esteroides (AINEs) na função renal em
pacientes com condições inflamatórias. Baseia-se em uma revisão integrativa da
literatura, cuja busca foi realizada na plataforma PubMed, utilizando os descritores e
palavras-chave: “Anti-Inflammatory Agents” AND "Nefrology" OR "Kidney Function
Tests". Adotou-se como critérios de inclusão: artigos publicados na íntegra, online, entre
2019 e 2024, no idioma inglês. Os estudos que não se relacionavam diretamente à
temática, artigos incompletos, duplicados nas bases de dados ou que se encontravam fora
da análise temporal foram excluídos. A busca resultou em 2700 estudos e 7 foram
analisados. A influência dos AINEs na Lesão Renal Aguda está associada à inibição das
prostaglandinas, que causa toxicidade renal. Observou-se que existe associação entre o
uso de AINES com a Nefrite Tubulointersticial (NTI), Síndrome Nefrótica (SN) e Doença
Renal Crônica (DRC), como implicações dos distúrbios hemodinâmicos. Salienta-se que,
os danos renais causados pelo uso de AINES não são comuns, fatores como idade
avançada, comorbidades e polifarmácia, aumentam o risco de nefrotoxicidade, devido à
redução na taxa da filtração glomerular. Entretanto, recomenda-se o uso desses
analgésicos em pacientes pós-traumatizados em substituição aos opióides. Além disso,
demonstrou-se que, em pacientes com função renal adequada, os AINES são os
analgésicos preferenciais para o tratamento da cólica renal, pois apresentam menos
reações adversas inespecíficas. Os anti-inflamatórios não esteroides (AINES) são
recomendados em casos de analgesia precoce, como em situações de acidentes graves ou
cólicas renais, mas seu uso em alguns pacientes pode estar relacionado a complicações
renais, sendo crucial que, ao prescrever esses medicamentos, a equipe de saúde alerta
sobre a importância do uso racional e às reações adversas medicamentosas, sobretudo
nefrotóxicos, relacionados ao uso dos anti-inflamatórios não esteroides.
COMORBIDADES ASSOCIADAS AO TRANSTORNO DO ESPECTRO AUTISTA: uma revisão bibliográfica
Authors: Silva Rayanne Medeiros da , Oliveira Luzianne Fernandes de , Martins Claudia Maria da Rocha
Published: May 2024

O Transtorno do Espectro do Autismo (TEA) é uma condição
complexa que se enquadra no grupo dos transtornos do
desenvolvimento, de acordo com os critérios estabelecidos pela American Psychiatric Association (APA), no Manual Diagnóstico e Estatístico de Transtornos Mentais (APA, 2014). Esses transtornos são caracterizados por apresentarem início durante o período infantil e afetam o desenvolvimento neurológico da criança, comprometendo suas relações pessoais, sociais, escolares e, posteriormente, acadêmicas e profissionais. O TEA, especificamente, é reconhecido como um transtorno do neurodesenvolvimento que se manifesta por meio de
desafios significativos nas áreas de comunicação, interação social e comportamentos repetitivos ou restritos, conforme definido pelo Manual de Orientação: Transtorno do Espectro do Autismo, desenvolvido pela Sociedade Brasileira de Pediatria (SBP, 2019).
Morular Metaplasia of the Endometrium: A Case Report and Literature Review: Care Pathways based on Molecular Biology
Authors: Dhanushka SK Kotigala , Tolu O Adedipe
Published: May 2024

Background: Endometrial morular metaplasia, a clinical conundrum from a diagnostic and management angle given its rarity and low oncogenic potential has been linked to endometrial hyperplasia and carcinoma. Case report: A 77-year-old woman with no significant past medical history was found to have an asymptomatic thickened endometrium on pelvic imaging, after presenting with lower abdominal pain, 3 yrs ago. Diagnostic hysteroscopy identified an endometrial polyp within a pyometra. Histopathology showed focal complex hyperplasia without atypia with superimposed morular metaplasia (EMM) amongst negative microbiology. Following conservative management with a Multidisciplinary Team (MDT) overview, as per her choice with 6-monthly follow-up hysteroscopies, endometrial biopsies, and a short use of the Mirena IUS (discontinued due to poor tolerance), histopathology shows resolved hyperplasia with persistent EMM. She is considering a hysterectomy. Discussion: Current evidence suggests that a sub-type of EMM, a likely histological manifestation of beta-catenin (CTNNB1) gene mutation: could be a precursor of endometrial hyperplasia and low-grade endometrioid-endometrial carcinoma sub-type. Though low-grade in nature, the increased recurrence risk raises significant concerns. Management options which include conservative, hormonal, and surgery have been described in the literature. A few cases of premenopausal women have been managed conservatively, with one resulting in a pregnancy. However, due to the lack of a natural history timeline, the optimal frequency of endometrial sampling when uterine-sparing, is unclear, leading to a management conundrum. Conclusion: Management of morular endometrial metaplasia can be difficult but must reflect the woman’s choice with an MDT overview. Immuno-histochemical tools utilizing new molecular biological advances can simplify the diagnostic and prognostication processes, aiding clinical management.
Using Chat GPT to Clean Qualitative Interview Transcriptions: A Usability and Feasibility Analysis
Authors: Taylor Zachary
Published: May 2024

One of the major inefficiencies in qualitative research is the accuracy and timeliness of transcribing audio files into analyzable text. However, researchers may now have the ability to leverage artificial intelligence to increase research efficiency through Chat GPT. As a result, this study performs feasibility and accuracy testing of Chat GPT versus human transcription to compare accuracy and timeliness. Results suggest that by using specific commands, Chat GPT can clean interview transcriptions in seconds with a <1% word error rate and near 0% syntactic error rate. Implications for research and ethics are addressed.