bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of the Knockdown Resistance Locus (kdr) in Anopheles stephensi, An. arabiensis, and Culex pipiens s.l. for Insight Into the Evolution of Target-site Pyrethroid Resistance in Eastern Ethiopia
Authors: Carter Tamar E. , Gebresilassie Araya , Hansel Shantoy , Damodaran Lambodhar , Montgomery Callum , Bonnell Victoria , Lopez Karen , Janies Daniel , Yared Solomon
Published: January 2022

The malaria vector, Anopheles stephensi, which is typically restricted to South Asia and the Middle East, was recently detected in the Horn of Africa. Addressing the spread of this vector could involve integrated vector control that considers the status of insecticide resistance of multiple vector species in the region. Previous reports indicate that the knockdown resistance mutations (kdr) in the voltage-gated sodium channel (vgsc) are absent in both pyrethroid-resistant and pyrethroid-sensitive An. stephensi in eastern Ethiopia; however, similar information about other vector species in the same areas is limited. In this study, kdr and the neighboring intron were analyzed in An. stephensi, An. arabiensis, and Culex pipiens s.l. collected between 2016 and 2017 to determine the evolutionary history of kdr in eastern Ethiopia. A sequence analysis revealed that all of Cx. pipiens s.l. (N = 42) and 71.6% of the An. arabiensis (N = 67) carried kdr L1014F, which is known to confer target-site pyrethroid resistance. Intronic variation was only observed in An. stephensi (six segregating sites, three haplotypes), which was previously shown to have no kdr mutations. In addition, no evidence of non-neutral evolutionary processes was detected at the An. stephensi kdr intron, thereby further supporting the target-site mechanism not being a major resistance mechanism in this An. stephensi population. Overall, these results show key differences in the evolution of target-site pyrethroid/dichlorodiphenyltrichloroethane resistance mutations in populations of vector species from the same region. Variations in insecticide resistance mechanism profiles between eastern Ethiopian mosquito vectors may lead to different responses to insecticides used in integrated vector control.
Impact of a Novel, Low-Cost and Sustainable Health Education Program on the Knowledge, Attitudes, and Practices Related to Intestinal Schistosomiasis in School Children in a Hard-to-Reach District of Madagascar
Authors: Spencer Stephen A. , Andriamasy Emmanuel H. , Linder Cortland , Penney James M. StJ. , Henstridge-Blows Jemima , Russell Hannah J. , Hyde Kate , Sheehy Caitlin , Young Isla L. , Sjoflot Benedicte , Rakotomampianina Daniel A. L. , Nandimbiniaina Anjara M. , Raderalazasoa Gina U. , Ranaivoson Tahiry N. , Andrianiaina Antsa , Michèle Rasolofomanana S. M. , Rohe Zafera A. , Bustinduy Amaya L. , Stothard J. Russell , Cruickshank Sheena M. , Edosoa Glenn T. , Rahetilahy Alain M.
Published: January 2022

Schistosomiasis control requires multisectoral approaches including praziquantel treatment, access to safe water, sanitation and hygiene, and health education. Community input can help ensure health education programs are culturally appropriate to effectively direct protective behavior change. This study reports on the three-stage development of an education program for Malagasy children, with an impact evaluation on their knowledge, attitudes, and practices (KAP) related to intestinal schistosomiasis. A cross-sectional study took place in 2017 with follow-up in 2018 in the hard-to-reach Marolambo district, Madagascar. A novel schistosomiasis education program (SEP) was designed in collaboration with researchers, stakeholders, and local community and included cartoon books, games, songs, puzzles, and blackboard lessons, costing $10 USD per school. KAP questionnaires were completed by 286 children pre-SEP and 273 children post-SEP in 2017, and by 385 and 337 children pre-SEP and post-SEP, respectively, in 2018. Improvements were observed in responses to all questions between pre- and post-education answers in 2017 (53–77%, P < 0.0001) and 2018 (72–98%, P < 0.0001) and in the pre-education answers between years (53–72%, P < 0.0001). Praziquantel mass drug administration attendance improved, rising from 64% to 91% (P < 0.0001), alongside improved latrine use, from 89% to 96% (P = 0.005). This community-consulted and -engaged SEP resulted in substantial improvements in children’s understanding of schistosomiasis, with improvements in praziquantel uptake and latrine use. Socioculturally tailored education programs can help gain schistosomiasis control. Continued investment in SEP will help promote the future well-being of children through increased participation in control and treatment activities.
Active Pharmacovigilance for Primaquine Radical Cure of Plasmodium vivax Malaria in Odisha, India
Authors: Anvikar Anupkumar R. , Sahu Prajyoti , Pradhan Madan M. , Sharma Supriya , Ahmed Naseem , Yadav Chander P. , Pradhan Sreya , Duparc Stephan , Daumerie Penny G. , Valecha Neena
Published: January 2022

Plasmodium vivax malaria elimination requires radical cure with chloroquine/primaquine. However, primaquine causes hemolysis in glucose-6-phosphate dehydrogenase-deficient (G6PDd) individuals. Between February 2016 and July 2017 in Odisha State, India, a prospective, observational, active pharmacovigilance study assessed the hematologic safety of directly observed 25 mg/kg chloroquine over 3 days plus primaquine 0.25 mg/kg/day for 14 days in 100 P. vivax patients (≥ 1 year old) with hemoglobin (Hb) ≥ 7 g/dL. Pretreatment G6PDd screening was not done, but patients were advised on hemolysis signs and symptoms using a visual aid. For evaluable patients, the mean absolute change in Hb between day 0 and day 7 was −0.62 g/dL (95% confidence interval [CI]: −0.93, −0.31) for males (N = 53) versus −0.24 g/dL (95%CI: −0.59, 0.10) for females (N = 45; P = 0.034). Hemoglobin declines ≥ 3 g/dL occurred in 5/99 (5.1%) patients (three males, two females); none had concurrent clinical symptoms of hemolysis. Based on G6PD qualitative testing after study completion, three had a G6PD-normal phenotype, one female was confirmed by genotyping as G6PDd heterozygous, and one male had an unknown phenotype. A G6PDd prevalence survey was conducted between August 2017 and March 2018 in the same region using qualitative G6PD testing, confirmed by genotyping. G6PDd prevalence was 12.0% (14/117) in tribal versus 3.1% (16/509) in nontribal populations, with G6PD Orissa identified in 29/30 (96.7%) of G6PDd samples. Following chloroquine/primaquine, notable Hb declines were observed in this population that were not recognized by patients based on clinical signs and symptoms.
Fake news and copyright
Authors: Bonadio Enrico , Lucchi Nicola , Pollicino Oreste
Published: January 2022

As is known, new technologies have profoundly changed the way content is produced, shared and disseminated. One of the most recent (and worrying) changes is the phenomenon of ‘fake news’, especially since disinformation and intentional misrepresentation of real information have started to affect individual decision-making in the political sphere. It is a worrying phenomenon because the dissemination of fake news can challenge democratic values and undermine national security.

Against this background, can copyright play a role in the fight against fake news? And what is the relationship between such news and copyright in the first place? Fake news in theory falls within copyright subject matter and may often meet the requirements for protection. The paper analyses three recent examples of fake news which have been widely disseminated online – and makes the point that copyright may subsist in such news. Yet, despite such content being potentially capable of attracting protection, we propose to remove any copyright which may arise on grounds of public interest. Indeed, when a work is protected by copyright, right holders have an incentive to exploit it, as the monopoly granted to them increases the ability to extract profits out of the work, for example via licensing. This may contribute to encouraging creators of fake news to spread such content across multiple channels to reach wide audiences. Excluding copyright could therefore help make fake news less appealing. A short reference will also be made to copyright defences which may be relied on by entities and individuals who check news’ accuracy (fact-checkers) – that is, the fair use doctrine under US law and several exceptions under EU (and UK) law, namely transient use, text and data mining, criticism and review and public security.

* All authors contributed equally to this manuscript and are listed alphabetically.
Determinants of Behavioural Intention Towards Travel Applications in an Emerging African Economy: A Perspective on the Hospitality Industry
Authors: Ledikwe Aobakwe
Published: January 2022

This study is aimed at uncovering the determinants of behavioural intention towards travel applications in an emerging economy of South Africa. A descriptive and quantitative design was employed, and primary data (n=420) was gathered from participants using an online questionnaire. Structural equation modelling was applied to examine the theoretical connection between the dimensions of experiencescape, memorability, satisfaction, and behavioural intention. The results prove that the dimensions of experiencescape (entertainment, escapism, and aesthetics), memorability, satisfaction, and behavioural intention are positively and significantly related. Therefore, the promotion of experiencescape, memorability, and satisfaction is an important area of concern among hospitality providers in developing a consistent and enduring service experience that can stimulate behavioural intention towards travel applications.
The Fear of COVID-19 Pandemic in Triggering Tourists' Material Deprivation, Social Rights, Social Participation, and Cultural Integration: The Mediating Role of Bullying
Authors: Al-Azab Mahmoud Ramadan , Darwish Alyaa , Salem Islam Elbayoumi , Elbaz Ahmed Mohamed
Published: January 2022

The paper investigated the impact of the fear of the COVID-19 pandemic on tourists' social exclusion in terms of material deprivation, social rights, social participation, and cultural/normative integration, through the mediating role of bullying, in the early days of COVID-19 pandemic. Drawing on social exclusion theory, we adopted a quantitative approach and an integrative model to collect data from 473 tourists through a web-based survey from 5th March to 17th June 2020. The results demonstrated that the fear of COVID-19 has a significant influence on tourists’ social exclusion, and in turn, has led to bullying. Besides, bullying has a significant influence on material deprivation, social rights, social participation, and cultural/normative integration of social participation. In addition, this study determined that the effect of the fear of COVID-19 on tourists' social exclusion is partially mediated by bullying. This study also draws attention to the importance of upholding the values of humanity and positive human transactions in times of crisis and pandemics.
A Critical Review of Environmental Governance, Land Restitution, and Tourism in Protected Areas
Authors: Ramukumba Takalani
Published: January 2022

Natural areas, when protected, conserve the natural environment and function as social spaces in which tourism brings increased income, employment, and financial support for conservation. The inclusion of local community members in the planning and management of protected areas has been on the rise since the early 1900s. Tourism has been advocated as a strategy that can help in achieving economic development, especially in rural areas. However, governance issues and potential negative impacts of tourism development have been under inspection. Conservation efforts in Southern Africa especially in the late 1800s and early 1900s had negative impacts on the local communities since this led to many communities being displaced or having limited access to these protected areas. This has seen the need for ways and efforts to get local community members' despondency and attitudes towards protected areas change such that in the 20th century, there were efforts to use conservation models that included community members in the decision-making and benefit-sharing process to garner their support for protected areas. This paper reviews literature on environmental governance, land restitution in protected areas, tourism in protected areas, co-management, and the importance of community participation. These concepts are reviewed using Manyeleti Game Reserve as a case study.
Comparison of SPS and FA methods for Blind Carrier Frequency Offset Estimation in OFDM systems
Authors: Sastry K. Seshadri , Baburao K. , Prabu A.V. , Kumar G.Naveen
Published: January 2022

In orthogonal frequency-division multiplexing (OFDM) systems, synchronization issues are of great importance since synchronization errors might destroy the orthogonality among all subcarriers and, therefore, introduce intercarrier interference (ICI) and intersymbol interference (ISI). Several schemes of frequency offset estimation in OFDM systems have been investigated. This paper compares performance and computational complexity of Smoothing Power Spectrum (SPS) and Frequency Analysis (FA) methods for blind carrier frequency offset (CFO) estimation in OFDM systems.
The Modified Procedure of Totally Tubeless PNL
Authors: Sahalevych Andriy I. , Sergiychuk Roman V. , Ozhohin Vladislav V. , Khrapchuk Andriy Yu. , Dubovyi Yaroslav O. , Frolov Olexander S.
Published: January 2022

Mini percutaneous nephrolithotomy (mPNL) is a standard treatment for kidney stones larger than 1.5 cm, with the placement of a nephrostomy drainage at the end of it, which is considered the standard procedure, but tubeless/ totally tubeless mPNL techniques reduce postoperative discomfort in patients and shorten hospital stays. The aim of article was to compare the efficacy and safety of our proposed modified method of totally tubeless mPNL with control of the parenchymal canal, with existing methods of tubeless/totally tubeless mPNL. Novelty of the study presented by modified method of totally tubeless mPNL. During the period from 2018 to 2020 we performed 486 mPNL were performed in our clinic in total, among which 63 (12.9%) patients underwent tubeless PNL. Patients whose surgeries ended with using tubeless techniques were divided into three groups: Group I – 22 patients who had tubeless mPNL (with ureteral stent), Group II (20 patients) – totally tubeless mPNL with a safety thread (the proposed procedure), Group III (21 patients) – totally tubeless mPNL. In all three groups, the access point was most often made through the lower group of renal calyces: Group I – 12 (54.5%), Group II – 14 (70.0%), Group III – 13 (61.9%); then through the middle calyx: Group I – 8 (36.4%), Group II – 6 (30.0%), Group III – 7 (33.3%); and the upper calyx: Group І – 2 (9.1%), Group ІІ – 0%, Group ІІІ – 1 (4.8%), no differences in the distribution of access points between groups were found (p=0.67). There were no differences in the distribution of tract sizes between the groups (p=0.95) with tract dilatation to 16.5/17.5 Fr was performed most often: Group I – 12 (54.5%), in Group II – 11 (55.0%) and Group III – 11 (52.4%). The mean duration of surgery in Group I was 83.0±22.9 min, in Group II – 74.9±13.6 min, in Group III – 72.6±12.0 min (p=0.47). This study confirms the high effectiveness of totally tubeless mPNL. The proposed modification to perform totally tubeless mPNL allows you to have permanent postoperative control over the parenchymal channel and in case of postoperative bleeding it enables you to immediately insert nephrostomy drainage through the safety thread. Study contributes to practical methods as an intermediate step for surgeons who are considering transition to a totally tubeless PCNL technique.
Distribution of Polymorphic Markers of Genes Encoding the Renin-angiotensin System (ACE, AGT, AGTR1), ITGB3, PPARG, Pparg in Patients With Essential Hypertension Depending on the Age
Authors: Zotova Tatyana , Azova Madina , Lukanina Anastasia , Aissa A. Ait , Blagonravov Mikhail
Published: January 2022

Essential hypertension (EH) is a multifactorial disease with a hereditary predisposition. Genes encoding the renin-angiotensin system (RAS) play a leading role in the stabilization of elevated BP in the course of EH, which determines the relevance of our clinical and genetic study. The study was based on the determination of the frequencies of polymorphic markers of the AGT, AGTR1, ACE, ITGB3, PPARG genes in 2 groups, depending on the age of patients (up to 60 years - group1, n=18, and after 60 years - group2, n=31), for the intergroup frequencies comparison and comparison of group frequencies with population data. Genotyping by gene polymorphisms was performed by real-time polymerase chain reaction. 24-hour ambulatory BP monitoring (ABPM) and Holter HR monitoring were conducted. Phenotypic features of the course of EH were accompanied by changes in the frequency characteristics of the studied genotypes. In patients of group 1, an increase in the frequency of protective genotypes of the ACE(II) and ITGB3(TT) genes was observed (p=0.004;0.015), which confirms the hypothesis of a possible favorable course of EH in patients under 60 years.
Heart Disease Prediction Using Glowworm Swarm Optimization and Support Vector Machine Classifier
Authors: Bhaskaru O. , , Sreedevi M.
Published: January 2022

At present, health disorder is growing day by way of the day due to existence lifestyle, hereditary. Particularly, heart disease has ended up greater frequent these days. Heart disorder prognosis technique is very quintessential and integral trouble for the patient's health. Besides, it will help out to limit disorder to a larger distinctive level. The role of using strategy like machine learning and algorithm such as heart disease diagnosis using Data Mining(DM) techniques is very significant. In the previous system, the Fuzzy Extreme Learning Machine (FELM) was proposed to predict heart disease, ensuring an accurate and timely diagnosis. However, it only achieves 87.14 % of accuracy. To improve the classification accuracy, the proposed system designed an Improved Step Adjustment based Glowworm Swarm Optimization Algorithm with Weighted Feature based Support Vector Machine (ISAGSO-WFSVM) for Heart disease diagnosis. This proposed venture utilizes the dataset of heart disease for input. Using the Improved Step Adjustment based Glowworm Swarm Optimization Algorithm (ISAGSO) to enhance the true positive rate, optimal features are then selected. Finally, with the aid of the Weighted Feature based Support Vector Machine (WFSVM) classifier, classification is carried out relying selected features. In the proposed method, better performance obtained and that is validated through the experimental results in terms of precision, accuracy, recall and f-measures
Riemann Zeta Based Surge Modelling of Continuous Real Functions in Electrical Circuits
Authors: Thankappan Binesh
Published: January 2022

Riemann zeta is defined as a function of a complex variable that analytically continues the sum of the Dirichlet series, when the real part is greater than unity. In this paper, the Riemann zeta associated with the finite energy possessed by a 2mm radius, free falling water droplet, crashing into a plane is considered. A modified zeta function is proposed which is incorporated to the spherical coordinates and real analysis has been performed. Through real analytic continuation, the single point of contact of the drop at the instant of touching the plane is analyzed. The zeta function is extracted at the point of destruction of the drop, where it defines a unique real function. A special property is assumed for some continuous functions, where the function’s first derivative and first integral combine together to a nullity at all points. Approximate reverse synthesis of such a function resulted in a special waveform named the dying-surge. Extending the proposed concept to general continuous real functions resulted in the synthesis of the corresponding function’s Dying-surge model. The Riemann zeta function associated with the water droplet can also be modeled as a dying–surge. The Dying- surge model corresponds to an electrical squeezing or compression of a waveform, which was originally defined over infinite arguments, squeezed to a finite number of values for arguments placed very close together with defined final and penultimate values. Synthesized results using simulation software are also presented, along with the analysis. The presence of surges in electrical circuits will correspond to electrical compression of some unknown continuous, real current or voltage function and the method can be used to estimate the original unknown function.
Study on Fuzzy ELECTRE Method with Various Methodologies
Authors: Sathiyaraj Chinnasamy , Ramachandran M , Kurinjimalar Ramu , Anusuya P
Published: January 2022

The purpose of this thesis is to develop a MCDM system based on a deletion and selective translation reality (ELECTRE) Assessment information is expressed and manipulated by the Tempster-Schaefer Theory (DST). DST is the primary means for uncertainty modeling. In this paper, the weight of the criteria and the effectiveness of each alternative are expressed in terms of linguistic terms and belief levels, which are then converted into basic probability assignment (BPA) representations. In order to integrate the evaluations of different experts in the most rational and efficient manner, a
discount system in DST is provided Based on the proposed concept of source reliability. In addition, as a family of MCDM models, the ELECTRE system is known for its superior relationships in ordering a set of alternatives. As an extension, artificial weight, including subjective and objective weights, is used to determine concepts of synchronization and variance. The proposed DS-ELECTRE approach directly reflects the advantage of DST and deals with uncertainty, but the ELECTRE method can also play a role in analyzing the relationships between alternatives. An illustrative number example is conducted to demonstrate the effectiveness of the DS-ELECTRE method. The final result matrix can be obtained based on the fusion results, which will then be used in ELECTRE mode. At this point, the transcendental relationships between all pair alternatives are structured in ELECTRE mode using concepts of synchronization and contrast, which are Represented by some corresponding matrix. A result chart will be drawn based on the resulting global matrix, and the ranking results will be analyzed to determine the appropriate provider. In short, a new ELECTRE-based system has been developed to address MCDM issues in DST contexts, which can be considered by decision makers. non-formal evaluation
and apply incomplete or insufficient knowledge of data. Therefore, in this study, a comprehensive Weight including subjective weight and objective weight is defined in the process of ELECTRE method to make the synchronization and contrast metrics more reasonable. Subjective weight is obtained only on the basis of decision makers ’preferences or judgments, and objective weight is determined using the entropy weight method.
Thai trứng lạc chỗ ở đoạn kẽ: Ca lâm sàng, tổng quan chẩn đoán và điều trị
Authors: Dương Văn Sang , Lê Sĩ Phương
Published: January 2022

Thai trứng lạc chỗ hiếm khi xảy ra, do đó thường ít được nghĩ đến để cân nhắc chẩn đoán trên lâm sàng. Hình ảnh siêu âm kết hợp với giá trị hCG cao bất thường so với tuổi thai gợi ý bệnh lí thai trứng. Chẩn đoán thai trứng dựa vào tiêu chuẩn vàng mô bệnh học. Chúng tôi báo cáo một trường hợp thai trứng lạc chỗ ở đoạn kẽ tử cung. Bệnh nhân được điều trị phẫu thuật nội noi bằng kỹ thuật khâu thắt miệng túi trước khi xẻ góc tử cung và được theo dõi sau phẫu thuật.
Traditional use of plants in Kuršumlija
Authors:   University of Kragujevac, Faculty of Sciences, Đelić Gorica , Simović Goran , Stanković Milan , Zlatić Nenad , Todorović Marija , Pavlović Milica
Published: January 2022

Plants as a source of active phytochemistry are the basis of nutrition. However, man uses them in traditional medicine and veterinary medicine, but also as raw materials in many branches of industry (textile, construction…). The need and role of traditional medicines in the health care system havе been growing in recent decades. The aim of the research is to determine the list of plants that are traditionally used by the local population on the territory of the municipality of Kuršumlija, and the way of their application in folk medicine, veterinary medicine, customs. Data on knowledge of plants and their use were collected through interviews in the period from May to September 2020. A total of 49 people were interviewed (37.5% men and 62.5% women), aged between 21 and 81, mostly from urban areas (79.2% of respondents are from the city and 20.8% from rural areas). Respondents have different education: 6.3% have a primary school, 58.3% have a secondary school and 35.4% have higher education. During the research, it was stated that the largest number of plant species used for therapeutic purposes belongs to families: Lamiaceae (20.5%), Asteraceae (12.8%), Rosaceae (5.1%) and the most commonly used species are: Mentha piperita (47.9% of respondents), Matricaria chamomilla (37.5% of respondents); Urtica dioica (31.2% of respondents); Hypericum perforatum (27% of respondents), Salvia officinalis (22.9% of respondents); Achillea millefolium (14.5% of respondents); Ocimum basilicum (12.5% ​​of respondents). For therapeutic purposes, teas (infusion, decoction), tinctures, and oils are prepared for oral use, and for external use, compresses and ointments. The largest number of respondents reported the use of herbal medicines for the treatment of gastrointestinal and respiratory organs. In the customs related to religious holidays, the largest number of respondents use oak.
TU OU VOCÊ: O PARADIGMA PRONOMINAL DE SEGUNDA PESSOA DO SINGULAR EM FLORIANÓPOLIS
Authors: FERREIRA ANGELO WAGNER
Published: January 2022

PESQUISAS MOSTRAM QUE NO SUL DO BRASIL HÁ A PREFERÊNCIA PELO USO DO PRONOME PESSOAL TU E SUAS VARIÁVEIS EM RELAÇÃO AO VOCÊ. ISSO SE DEVE PELOS ESPAÇOS GEOGRÁFICOS QUE DEMARCAM AS COMUNIDADES DE FALA. A PRESENTE PESQUISA INTENTOU INVESTIGAR O PORQUÊ DA PREFERÊNCIA DE USO DO PRONOME PESSOAL DE SEGUNDA PESSOA DO SINGULAR TU EM FLORIANÓPOLIS. PARA TANTO, PARTIU-SE DO PRINCÍPIO DE QUE O DIALETO PERTENCENTE À COMUNIDADE DE FALA CONHECIDA COMO “MANEZINHA” SE UTILIZA DESSE PRONOME PESSOAL – E SUAS VARIAÇÕES – QUE PODE SE TRATAR DE UMA POSSÍVEL HERANÇA LINGUÍSTICA AÇORIANA. PARA REALIZAR ESTA PESQUISA SE TOMOU POR BASE TEÓRICA OS PRECEITOS METODOLÓGICOS DA TEORIA SOCIOLINGUÍSTICA DESCRITOS POR TARALLO. ATRAVÉS DA APLICAÇÃO DE DUAS FICHAS/QUESTIONÁRIOS SE APANHOU – DE MODO GERAL – QUE HÁ A POSSIBILIDADE DE INFLUÊNCIA AÇORIANA (PORTUGUESA) SOBRE O USO DO PRONOME PESSOAL DE SEGUNDA PESSOA DO SINGULAR POR PARTE DOS “MANEZINHOS”.
ESTÁGIO SUPERVISIONADO NO CURSO DE PEDAGOGIA: EM BUSCA DE NOVAS PRÁTICAS
Authors: SARLO CARNEIRO CHRYSÓSTOMO CARLA
Published: January 2022

O ESTÁGIO SUPERVISIONADO PROPORCIONA AO LICENCIADO O DOMÍNIO DE INSTRUMENTOS TEÓRICOS E PRÁTICOS NECESSÁRIOS À EXECUÇÃO DE SUAS FUNÇÕES VISANDO BENEFICIAR A EXPERIÊNCIA, ALÉM DE PROMOVER O DESENVOLVIMENTO NO CAMPO PROFISSIONAL, DOS CONHECIMENTOS TEÓRICOS E PRÁTICOS ADQUIRIDOS DURANTE O CURSO FAVORECENDO, POR MEIOS DE DIVERSOS ESPAÇOS EDUCACIONAIS, A AMPLIAÇÃO DO UNIVERSO CULTURAL DOS FUTUROS PROFESSORES. O OBJETO DE ESTUDO SÃO PRÁTICAS VIRTUAIS DOCENTES. TENDO COMO TEMA ESTÁGIO VIRTUAL NO CURSO DE PEDAGOGIA. O PÚBLICO ALVO SÃO 16 ALUNOS DO SÉTIMO PERÍODO DO CURSO DE PEDAGOGIA DO INSTITUTO SUPERIOR DE EDUCAÇÃO PROFESSOR ALDO MUYLAERT / ISEPAM. O PROBLEMA QUESTIONA O PORQUÊ DOS ALUNOS DO CURSO DE PEDAGOGIA TEREM RESISTÊNCIA ÀS AULAS REMOTAS DURANTE O ESTÁGIO UTILIZANDO A TECNOLOGIA. AS HIPÓTESES SE RESUMEM EM: AUSÊNCIA DE RECURSOS TECNOLÓGICOS NA INSTITUIÇÃO E NOS CURRÍCULOS DISCIPLINARES QUE APROXIMEM TEORIA DA PRÁTICA. MACHADO E MORAES (2015) EXPLICAM QUE ESSA NOVA VISÃO EDUCACIONAL REQUER UMA POLÍTICA CIVILIZACIONAL BASEADA NA RACIONALIDADE TÉCNICA, NO APARATO TECNOLÓGICO E NO “PHATOS”, QUE É A SENSIBILIDADE NA ESTÉTICA DO PENSAMENTO E NA RESPONSABILIDADE SOCIAL.
OS EFEITOS DE SENTIDO DESEMPENHADOS PELOS OPERADORES ARGUMENTATIVOS EM ANÚNCIOS PUBLICITÁRIOS
Authors: GONCALVES DE ANDRADE MOREIRA RAISSA
Published: January 2022

O TEMA DESTE TRABALHO SÃO OS OPERADORES ARGUMENTATIVOS. INGEDORE KOCH (2006), EMBASADA NOS FUNDAMENTOS DE OSWALD DUCROT (1972), DESTACA QUE OS OPERADORES ARGUMENTATIVOS SÃO ELEMENTOS LINGUÍSTICOS DOTADOS DE INFORMAÇÕES E FUNCIONAM COMO DISPOSITIVOS QUE LEVAM A ARGUMENTAÇÃO DE UM LOCUTOR PARA UM INTERLOCUTOR. PARA ANÁLISE, APOIAMO-NOS EM ANÚNCIOS PUBLICITÁRIOS RETIRADOS DA INTERNET. PARA TANTO, TOMAMOS COMO BASE A PERSPECTIVA DA SEMÂNTICA ARGUMENTATIVA, POR ACREDITARMOS QUE OS USUÁRIOS DE UMA LÍNGUA, AO UTILIZAREM-SE DE ESTRATÉGIAS DISCURSIVAS, APLICAM-NAS COM ALGUMA INTENÇÃO. NESTE SENTIDO, OBJETIVAMOS ANALISAR AS OCORRÊNCIAS DOS OPERADORES ARGUMENTATIVOS EM ANÚNCIOS PUBLICITÁRIOS, BEM COMO VERIFICAR OS EFEITOS DE SENTIDOS DESEMPENHADOS POR ESSES MECANISMOS DE ACORDO COM O PROPÓSITO COMUNICATIVO, NO CASO DOS ANÚNCIOS PUBLICITÁRIOS, DE CONVENCER/PERSUADIR O INTERLOCUTOR SOBRE ALGUMA AÇÃO. COMO RESULTADOS, NOS ANÚNCIOS PUBLICITÁRIOS VERIFICAMOS QUE OS OPERADORES NÃO FORAM UTILIZADOS APENAS COMO UM CONECTIVO QUE ESTÁ LIGANDO ORAÇÕES OU SINTAGMAS, MAS COMO UM ELEMENTO QUE POSSUI FORÇA ARGUMENTATIVA E QUE DIRECIONAM O SENTIDO DA ARGUMENTAÇÃO, QUE O LOCUTOR CONSTRÓI A PARTIR DO PROPÓSITO COMUNICATIVO.
LETRAMENTO DIGITAL VERSUS ENSINO REMOTO: RELATOS DE PROFESSORES DA REDE PÚBLICA DA PARAÍBA SOBRE O ENSINO DE LÍNGUA PORTUGUESA
Authors: DOS SANTOS MENDES COPPI DANIELLE , DANTAS DA SILVA CLARICE , FRANCISCO GOMES JOELSON
Published: January 2022

MEDIANTE O SURGIMENTO DA PANDEMIA DA COVID-19 E DO ENSINO REMOTO EMERGENCIAL, AS FERRAMENTAS DIGITAIS SE TORNAM MAIS PRESENTES NO AMBIENTE ESCOLAR, NA PRÁTICA DOCENTE E NA VIDA DOS EDUCANDOS. PENSANDO NESSE CONTEXTO, ESSA PESQUISA TEM COMO OBJETIVO GERAL INVESTIGAR COMO AS FERRAMENTAS DIGITAIS IMPACTARAM NO ENSINO DE LÍNGUA PORTUGUESA E COMO O LETRAMENTO DIGITAL SE SITUA NESSA NOVA PRÁTICA SOCIAL, QUE É O ENSINO REMOTO. NESSE SENTIDO, RECORREMOS AOS PRESSUPOSTOS TEÓRICOS DE SOARES (2014), ROJO (2012), XAVIER (2011), KENSKI (2007), SILVA (2020), ENTRE OUTROS. METODOLOGICAMENTE, ESTA PESQUISA APOIA-SE NA ABORDAGEM QUALITATIVA DE CARÁTER DESCRITIVO-INTERPRETATIVISTA, POIS BUSCAMOS INTERPRETAR E REFLETIR ACERCA DE UM FENÔMENO SOCIAL. ADEMAIS, A ESCOLHA DESSA TEMÁTICA DEU-SE PELO ANSEIO DE EVIDENCIARMOS OS IMPACTOS QUE A PANDEMIA DA COVID-19 CAUSOU NO ENSINO DE LÍNGUA PORTUGUESA. DIANTE DISSO, TOMAMOS COMO INSTRUMENTO DE INVESTIGAÇÃO UM QUESTIONÁRIO DISPONIBILIZADO A PROFESSORES DE LP QUE ATUAM NA REDE PÚBLICA DE ENSINO DA PARAÍBA. NO QUE TANGE AOS RESULTADOS, OBTIVEMOS RESPOSTAS QUE COMPROVAM OS IMPACTOS CAUSADOS PELA PANDEMIA NO ENSINO DE LP E EFETIVAM A NECESSIDADE DE SE PRODUZIR AINDA MAIS FORMAÇÕES ACERCA DOS MULTILETRAMENTOS.
Current Advances in Computational biology of Lung Cancer
Authors:   Department of Tech. Biosciences, Digianalix, South Samaj Street, Tharpakhna, Ranchi, Jharkhand, INDIA. & Department of Biotechnology, Ranchi Women’s College, Circular Rd. Nagra Toli, Ranchi, Jharkhand, INDIA., Pati Purbasha
Published: January 2022

Lung cancer is the main basis of cancer death amongst men and women, making up almost 25% of the world’s total cancer deaths. Lung cancer described for nearly 1.6 million deaths in 2012 and 1.80 million deaths in 2020. Small cell lung cancer and non-small-cell lung cancer are the two key categories of Lung cancer. The signs of lung cancer include hemoptysis, weight loss, shortness of breath and chest pain. Lung cancer treated by chemotherapy, surgery and CT scan. In this review paper, one of the most crucial zones aiming lung cancer diagnosis has been discussed. Computer-aided diagnosis (CAD) systems adapted for lung cancer can increase the patients’ survival chances. A typical CAD system for lung cancer functions in the fields of lung segmentation, detecting lung nodules and the diagnosis of the nodules as benign or malignant. CAD systems for lung cancer are examined in a huge number of research case studies. CAD system steps and outlining of inhibitor genes at molecular level is being discussed. An insight into multi-omics and molecular dynamics simulations is also given in this paper.
Does the Covid-19 Outbreak Impacts On Economic Growth? An Evidence from Indonesia
Authors: Aprina Hilda , Majid M. Sabri Abd. , Silvia Vivi
Published: January 2022

This study aims to analyze the effectS of the COVID-19 pandemic, labor, domestic direct investment (DDI), AND foreign direct investment (FDI) on economic growth in Indonesia. The type of data used in this study is panel data, which is a combination of cross-section and THE time series data (Silvia, 2020). The cross-section data involves 34 provinces and time-series data covers the period from the first quarter of 2018 to the second quarter of 2021. The result found out that the regression coefficient of labor has a positive and significant effect at the 5 percent level, which means that if the number of workers increases by 1 percent, economic growth will increase by 0.03 percent. Furthermore, the FDI variable also has a significant and positive effect on economic growth in Indonesia. We can see in table 3.2 that the FDI variable is significant at the 5 percent level with a regression coefficient of 0.012, this means that an increase in FDI by 1 percent will accelerate economic growth by 0.012 percent. From the results of data processing obtained by the author, it can be seen that the DDI variable has a positive but not significant effect on economic growth in Indonesia, this can be seen from the p-value which is greater than 5 percent. The regression coefficient of -0.001 proves that the COVID-19 pandemic has a negative impact on economic growth in Indonesia. When the COVID-19 pandemic reached the territory of Indonesia, economic growth slowed by 0.001 percent.
Cases of Dispute and Pending Claims in Hospitals in the Era of National Health Insurance
Authors: Yastori Mrs.
Published: January 2022

Background: Indonesia began to implement a National Health Insurance System based on the National Social Security System in 2014 with the support of government regulations which states that Indonesia requires every citizen to have access to comprehensive and quality health services so that can continue their life through the National Health Insurance. Pending and dispute claims are problems that often occur in the era of national health insurance that can affect hospital budget allocation and planning policies, increasing the high cost burden for hospitals which will affect the quality of health services provided. The purpose of this study was to determine pending cases and dispute claims in hospitals in the Era of National Health Insurance.Methods: The study used a descriptive method with a qualitative approach. The data collection technique used is the observation method, namely directly to the e-claim file at several hospitals. 15 e-claim files taken in total from April – July 2021.Results: Obtained 13 cases of pending claims and 2 cases of dispute claims. Cases pending claims are caused by not complying with the code with evidence or resources, not in accordance with medical clinical practice guidelines and the rules of the health insurance provider.Conclusions: In coding, it is necessary to match the theory on the ICD-10, update the ICD-10. It is necessary to understand the rules and provisions made by the insurer and the related guidelines and rules. Please be aware of every latest code update.
Penggunaan Media KERAH WARNA untuk Meningkatkan Pemahaman dan Aktivitas Belajar Siswa Materi Pecahan Sederhana
Authors: Prianji Ajin Udi
Published: January 2022

Penelitian ini bertujuan untuk mengetahui peningkatan pemahaman dan aktivitas belajar siswa kelas VI SDN Banjarsugihan V/617, kota Surabaya dengan menggunakan media kerah warna. Kegiatan penelitian dilakukan di SDN Banjarsugihan V/617 kecamatan Tandes Kota Surabaya yang terdiri dari 12 ruang kelas. Peneliti menggunakan kelas VI B dengan 27 orang siswa. Waktu penelitian dilakukan pada bulan Maret 2020. Berdasarkan hasil pre test dari 27 siswa mendapatkan data bahwa terdapat 18 siswa yang masih berada di bawah KKM atau sekitar 66.7%. Sedangkan jumlah siswa yang berada di kriteria tuntas terdapat 9 siswa atau 33.3%. dengan nilai rata-rata kelas 61,1. Berdasarkan hasil post test dari 27 siswa yang diujikan. Diperoleh hasil bahwa terdapat 24 siswa yang telah memiliki kriteria tuntas atau sekitar 88.9 %. Sedangkan jumlah siswa yang berada di kriteria belum tuntas terdapat 3 siswa atau 11.1%. dengan nilai rata-rata kelas meningkat menjadi 78.5 Di dalam kegiatan belajar media KERAH WARNA yang dilakukan didapatkan aktivitas siswa memperhatikan apa yang disampaikan guru mendapat prosentase yaitu 11.6%, menjawab pertanyaan guru mendapat 9.2%, mengerjakan LKS yang diberikan guru 12.5%, bekerjasama dengan teman satu kelompok 12.5%, mendiskusikan masalah yang dihadapi dalam kelompok 10.6%, bertukan pendapat antar teman dalam kelompok 9.2%, mempresentasikan jawaban di depan kelas 12.5%, dan merespon jawaban teman mendapat 8.3%. dengan demikian aktivitas belajar siswa mendapat jumlah 91.2 % dari 100%. Hal ini membuktikan bahwa siswa menjadi lebih aktiv pada kegiatan pembelajaran menggunakan media KERAH WARNA.
Non-alcoholic fatty liver disease: current aspects of diagnosis in real clinical practice
Authors:   Omsk State Medical University, Omsk, Russia, Trukhan Dmitry I.
Published: January 2022

In the diagnosis and subsequent supervision of patients with non-alcoholic fatty liver disease (NAFLD) and obesity in real clinical practice, the role and importance of the doctor of first contact (therapist and general practitioner) increases. Non-alcoholic fatty liver disease is currently considered as the hepatic component of metabolic syndrome. A diagnostic algorithm for NAFLD at the stage of primary health care is presented. The most difficult question at 2–4 levels of the diagnostic algorithm is the differential diagnosis between NAFLD and alcoholic liver disease. During a pandemic of a novel coronavirus infection (COVID-19), patients with NAFLD or NASH, as a rule, have concomitant metabolic diseases such as diabetes mellitus, arterial hypertension and obesity, and also have to take a large number of potentially hepatotoxic drugs, it is advisable to classify them as elevated risk of infection with SARS-CoV-2, and the severe course of this infection. This allows us to consider NAFLD as dangerous in terms of the severe course of COVID-19, as viral hepatitis, autoimmune hepatitis and liver fibrosis / cirrhosis. It is known that NAFLD is an independent predictor of not only high cardiovascular risks, but also hepatocellular carcinoma and malignant neoplasms of various localization, as well as a number of other comorbid conditions. The review concludes with a clinical observation illustrating the difficulty of early diagnosis of intrahepatic cholangiocarcinoma in a patient with NAFLD and other metabolic risk factors.
Diagnosis of oral disorders in patients with chronic kidney disease
Authors:   Belarusian medical academy of postgraduate education, Minsk, Belarus, Lutskaya Irina K.
Published: January 2022

Chronic kidney disease results in severe disruptions to metabolic pathways, which contributes to tissue and organ damage, including damage to oral mucosa. A long-term condition limits the patient’s activity, which results in poor oral hygiene. Accumulation of dental plaque causes inflammation of the gums and follows the development of lesions in various areas of mucous membrane. Raches become long-lasting (chronic) and bother the patient. Bleeding gums immediately during hemodialysis is a clear manifestation of coagulation disorders. The research made it possible to develop guidelines on dental care in patients with CKD.
Role of glucometry in outpatient care, and managing patients with impaired carbohydrate metabolism
Authors:   Pirogov Russian National Research Medical University, Moscow, Russia, Demidova Tatiana Yu. , Larina Vera N. ,   Pirogov Russian National Research Medical University, Moscow, Russia
Published: January 2022

The patient should become a full-fledged partner of the physician in the question of diabetes mellitus treatment. Patient’s compliance and ability to perform structured self-monitoring have a direct impact on the treatment outcome. Patient education is a potential resource of treatment compliance. According to modern algorithms of care for patients with DM, patient training on blood glucose and blood pressure self-monitoring is a prerequisite for prevention and successful treatment of DM complications. Modern glucose meters, simple to use and comfortable, help to monitor blood glucose levels.
Rossolimo–Melkersson–Rosenthal syndrome in a 12-year-old adolescent: report of a rare case
Authors:   Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia, Glebova Larisa I. , Zadionchenko Ekaterina V. ,   Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia, Kliuchnikova Dina E. ,   Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia
Published: January 2022

Rossolimo–Melkersson–Rosenthal syndrome is quite rare in children and adolescents 3–4 to 12–16 years of age. It most commonly occurs as a monosymptom in the form of macrocheilia. The paper reports the causes of the disease, as well as its possible association with herpes simplex virus and staphylococcal infection.
Importance of blood glucose self-monitoring in treatment of diabetes mellitus in the modern world
Authors:   Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia, Biryukova Elena V.
Published: January 2022

Diabetes mellitus is a chronic disorder associated with microvasular and macrovascular complications, the prevention of which is an important challenge of modern medicine. Contemporary methods for diabetes management rely on the active involvement of the patient. Self-monitoring of blood glucose (SMBG) provides the basis for efficient antihyperglycemic therapy and prevention of hypoglycemia, as well as for the improvement of patient adherence to treatment. The importance of SMBG has further increased during the COVID-19 pandemic, since the adequate glycemic control can reduce the risk of COVID-19 infection and the disease severity in patients with DM. The recommended frequency of SMBG in patients with DM is discussed. A variety of glucose meters are available for measurement of blood glucose. Compliance with accuracy standards, simplicity and convenience for patients are the important criteria for selecting the glucose meter.
Theory about traumatic brain injury effects. Part II. Clinical and morphological forms of traumatic brain injury effects
Authors:   Burdenko national medical research centre for neurosurgery, Moscow, Russia, Likhterman Leonid B. , Kravchuk Aleksandr D. ,   Burdenko national medical research centre for neurosurgery, Moscow, Russia, Okhlopkov Vladimir A. ,   Burdenko national medical research centre for neurosurgery, Moscow, Russia
Published: January 2022

Clinical and morphological forms of traumatic brain injury effects are reported, distinguished based on the results, obtained during years of research in the National Medical Research Center for Neurosurgery. Basic criteria are proposed for the diagnosis of those based on the neurological and instrumental examination data, mostly on the neuroimaging data (CT, MRI, angiography).
Clinical analysis of cases of lichen ruber planus in the oral cavity
Authors:   Belarusian Medical Academy of Post-Graduate Education, Minsk, Belarus, Lutskaya Irina K. , Zinovenko Olga G. ,   Belarusian Medical Academy of Post-Graduate Education, Minsk, Belarus, Beloivanenk Irina O. ,   Belarusian Medical Academy of Post-Graduate Education, Minsk, Belarus
Published: January 2022

The manifestation of skin diseases in the oral cavity can be detected by doctors of any profile during the interview and examination of the patient. Often, the diagnosis is carried out by a dentist. A thorough diagnostic search allows you to determine the main clinical manifestations and treatment tactics. The dentist independently prescribes local therapy. A complex general effect is recommended by a dermatologist. Severe cases require inpatient treatment. A correct diagnosis and adequate medical measures improve the general condition and the local clinical picture, as well as contribute to a stable remission of the disease.
Oral manifestations of diabetes mellitus. Case report
Authors:   Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia, Novikova Irina A. , Panina Tatiana M. ,   National Medical Research Center for Preventive Medicine, Moscow, Russia
Published: January 2022

Type 2 diabetes mellitus is a violation of carbohydrate metabolism caused by insulin resistance and relative insulin insufficiency or a violation of insulin secretion with or without insulin resistance. The number of people with diabetes increased from 108 million in 1980 to 422 million in 2014. The World Health Organization (WHO) predicts that by 2030 this number will increase to 439 million, which is almost 10% of the adult population. A dentist is often the first to encounter manifestations of diabetes mellitus in the oral cavity, such as caries, candidiasis, dryness, inflammatory periodontal diseases, etc. Therefore, timely diagnosis and close interaction of doctors of different specialties is crucial for the treatment of this disease.
Syndrome of increased epithelial permeability, non-alcoholic fatty liver disease and cardiovascular diseases: what is the association and what ﻿can be done about it?
Authors:   Russian Gerontology Clinical Research Center branch of Pirogov Russian National Research Medical University, Moscow, Russia, Vorobyeva Natalia M. , Tkacheva Olga N. ,   Russian Gerontology Clinical Research Center branch of Pirogov Russian National Research Medical University, Moscow, Russia
Published: January 2022

Syndrome of increased epithelial permeability occurs due to a decrease in the barrier function of the gastrointestinal mucosa due to impaired intercellular interactions, resulting in bacterial translocation (i. e. penetration of bacteria and toxins from the gastrointestinal lumen into the bloodstream), which can initiate an inflammatory process in various diseases. Syndrome of increased epithelial permeability plays an important role in the pathogenesis of many chronic diseases, including cardiovascular and non-alcoholic fatty liver disease (NAFLD). In turn, the presence of NAFLD is associated with an increase in cardiovascular morbidity and mortality. The use of ursodeoxycholic acid in NAFLD allows reducing both hepatological and cardiovascular risks. Gastro- and enteroprotector rebamipide not only eliminates increased epithelial permeability and acts at all three levels of protection of the mucosepithelial barrier, but also has multiple pleiotropic effects, which opens up wide prospects for its use in cardiovascular diseases and NAFLD. The hepatoprotective and anti-sclerotic effects of rebamipide identified in experimental studies need further study in clinical trials in NAFLD patients.
Topical issues of differential diagnosis and treatment of cough during the pandemic
Authors:   Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia, Popova Elena N.
Published: January 2022

A cough is observed by medical practitioners of various specialties, and is among the most common symptoms of the broad range of disorders. The cause of coughing remains unclear in more than half of adults, who visit physicians with complaints of respiratory symptoms. The paper reports the principles of the cough differential diagnosis and treatment in patients with respiratory disorders, including during the pandemic; the cough features, characteristic of pulmonary fibrosis and COVID-19, are discussed. The clinical case of the 47-year-old patient, illustrating the need to use CT not only at onset, during the acute period of the disease, but also during the recovery period in patients with a lingering cough, is discussed as an example of the cough differential diagnosis.