bluuebunny/crossref_metadata_2025 huggingface dataset:
Sustento científico de la contabilidad a través del postulado de Mario Bunge
Authors: Pinto Perry Germán Rodolfo
Published: June 2023

El presente ensayo postula que el discurso de Mario Bunge sobre los atributos de una disciplina para ser considerada como una ciencia son aplicables claramente en la Contabilidad, no a través del cumplimiento de los diez criterios que este filósofo postuló para separar la ciencia de la pseudociencia, sino que, además de ese postulado, la contabilidad cumple cabalmente con aquellos que señalan que la teoría estudia la realidad generando modelos que son abstracciones de esa realidad y que la explican. Serán correctos esos modelos si son evaluados empíricamente y se demuestra la evidente correlación del modelo con la realidad que describen. Se demuestra que la esencia de la contabilidad genera abstracciones de los aspectos económicos, sociales y medioambientales de las entidades, a través de los modelos contables que corresponden, en alguna medida, al cuerpo normativo de las Normas Internacionales de Información Financiera. El cumplimiento de la contabilidad a la propuesta bungeana es tan palmario que se les exige a esas normas contables la verificación de la imagen fiel, siendo esto último, la evaluación empírica de ellas y, por ende, la evidencia completa del cumplimiento del postulado de Mario Bunge para validar su calidad científica.
Análisis de la manipulación de los resultados contables y fiscales de la adopción de las NIIF en las constructoras brasileñas
Authors: Alves Malosso Guilherme , Pelucio Grecco Marta Cristina , Lopes da Silva Fabiana
Published: June 2023

Este estudio tiene como objetivo identificar la influencia de los cambios derivados de la adopción de las Normas Internacionales de Información Financiera (NIIF) en la manipulación de resultados con efectos contables y fiscales en las empresas constructoras. Se utilizan como estudio los estados financieros, entre los periodos 2007 a 2009 (preconvergencia a NIIF) y 2010 a 2018 (posconvergencia a NIIF), de las empresas de este sector, listadas en B3 del Modelo Jones Modificado por Kothari. base., Leone & Wasley (2005) para medir la manipulación de resultados a través de devengos de una muestra de 14 empresas. En cuanto a los procedimientos metodológicos adoptados, la investigación se clasifica en método descriptivo, cuantitativo e inductivo. Los resultados sugieren que después de la adopción de la NIIF, hubo una reducción en la manipulación de los resultados contables y, por otro lado, un aumento en la manipulación de la base imponible de las empresas del sector de la construcción civil.
La inteligencia emocional: herramienta para el abordaje gerencial de conflictos organizacionales
Authors: Ivo Amadei Rafael
Published: June 2023

El artículo tiene por objetivo analizar la inteligencia emocional como herramienta para el abordaje gerencial de conflictos organizacionales A tal efecto, el estudio es cualitativo, con un diseño de campo a nivel descriptivo y bajo el método etnográfico. Los seis informantes clave son tres gerentes y tres empleados del Banco Estado de Chile, quienes dan respuesta al guion de entrevista semiestructurada; además, sus actividades laborales cotidianas se registran sistemáticamente en una guía de observación. El análisis crítico-reflexivo realizado desde el método inductivo de la comparación constante, evidencia la ausencia de estrategias efectivas para el tratamiento gerencial de conflictos, poca actitud dialógica entre las partes, Ausencia de la escucha activa y poco manejo de la asertividad y empatía, lo cual, merece ser objeto de reflexión y mejora con apoyo de la inteligencia emocional.
Las mediaciones TIC en la resolución de problemas matemáticos, un abordaje documental
Authors: Macías Rojas Mónica , Caro Edgar Orlando , Fernández Morales Flavio Humberto
Published: June 2023

El objetivo del presente estudio es identificar las tendencias en investigación con respecto a las mediaciones TIC y la resolución de problemas matemáticos, para lo cual se realiza una revisión documental de tipo hermenéutico, a través de un análisis sistemático en torno a lo trabajado en la última década. La búsqueda se realiza en bases de datos como: SciELO, RedALyC, Google Scholar y Dialnet, y se incluyeron artículos de revistas, tesis de maestría y doctorado, encontrando un total de 38 documentos para el análisis. Los resultados indican que en los últimos cuatro años son notorias las intervenciones en el aula a través de las TIC para fortalecer el Pensamiento Matemático, para lo cual se emplean materiales educativos tanto en línea como fuera de línea. La mayoría de las intervenciones están enfocadas hacia los estudiantes de educación básica, lo cual brinda una oportunidad para adelantar investigaciones en otros niveles formativos. Se puede concluir que la resolución de problemas y las mediaciones TIC son herramientas que transforman los procesos de enseñanza-aprendizaje, especialmente en la enseñanza de las matemáticas, resaltando los cambios en estudiantes y docentes al momento de contextualizarlas con nuevos aprendizajes.
Volatilidad del tipo de cambio y crecimiento económico: una revisión de los mecanismos de transmisión en economías en desarrollo
Authors: Romero Héctor , Ramoni Perazzi Josefa , Fajardo Eddy , Gómez Patiño Narly Valentina
Published: June 2023

La presente investigación tiene como propósito comprender los mecanismos de transmisión de la volatilidad del tipo de cambio sobre el nivel de actividad económica en las naciones en desarrollo. Para alcanzar este objetivo, se adelanta una investigación documental, realizando una búsqueda en la basa de datos de Scopus de todos los artículos relacionados con este tópico para un periodo de diecinueve años (2001 al 2020). Entre los hallazgos, se destaca que existen diversos canales de la transmisión de la volatilidad del tipo de cambio sobre el crecimiento económico; siendo los más relevantes en la coyuntura actual, los efectos sobre la dinámica de los precios, así como su incidencia en la producción industrial.
Causas de las desviaciones de los presupuestos en proyectos de construcción: Análisis bibliométrico
Authors: Sánchez Bedoya Natalia , Núñez Rodríguez Jairo , Villa Marulanda Marcela
Published: June 2023

Proyectos de construcción generan impactos ambientales, sociales y económicos, la buena planificación permite menos fluctuaciones en los resultados esperados ayudando a la sostenibilidad de las organizaciones y a generar lecciones aprendidas de experiencias anteriores, el estudio tiene como propósito definir las causas principales de las desviaciones de los presupuestos, para lo cual se utilizó la metodología de revisión sistemática de literatura aplicando el paso a paso expuesto por Tranfield, Denyer & Smart (2003) y utilizando la herramienta de VantagePoint, obteniendo como resultado un análisis bibliométrico y la identificación factores, como errores en el costeo, el cambio frecuente del diseño, la falta de experiencia del contratista y la demora en la toma de decisiones del cliente, como las principales causas en las desviaciones en los presupuestos.
Agricultural development as a contribution to the rural economy of Catatumbo, Norte de Santander
Authors: Báez Sandoval Giovanni Mauricio , Mogrovejo Andrade Johanna Milena , Bastos Osorio Liliana Marcela
Published: June 2023

Este artículo tiene por objetivo desarrollar aspectos agropecuarios que permitan determinar la economía rural y su crecimiento económico y social en la zona del Catatumbo, Norte de Santander. Destacando las oportunidades generadas en territorio mediante datos analizados de los principales entes de control y organizaciones de cooperación internacional. El método usado para el desarrollo de este escrito se basa en un estudio cualitativo descriptivo en dónde se identifican referentes organizacionales y de relevancia académica que ayudan a desglosar, identificar y plantear estrategias para el mejoramiento de las prácticas agropecuarias. Los resultados de la investigación de las áreas de unidades agropecuaria según su extensión en cada municipio de la región refleja la distribución de hectáreas del municipio del Carmen el cual cuenta con mayor cantidad de hectáreas con unidades de producción agropecuaria y un total de 158.879, le sigue Abrego con 102.859 hectáreas, Convenció con 91.403, Sardinita con 90.203, Teorema con 30.468, Ocaña con 25.216, Tib con 21.216, la playa con 11621 y Hacari con 5.975 hectáreas, quedando de ultimo San Calixto, debido a su porcentaje UPA de 0 y, el Tarra con 177 hectáreas. Se concluye las prácticas para las mejoras del sector que proporcionen la ampliación de ingresos y la disminución de la pobreza multidimensional.
3D bioprinting of corneal decellularized extracellular matrix: GelMA composite hydrogel for corneal stroma engineering
Authors: Zhang Mingshan , Yang Fang , Han Daobo , Zhang Shi-yao , Dong Yipeng , Li Xinyu , Ling Liyun , Deng Zhichao , Cao Xuewei , Tian Jianguo , Ye Qing , Wang Yan
Published: June 2023

Millions of individuals across the world suffer from corneal stromal diseases that impair vision. Fortunately, three-dimensional (3D) bioprinting technology which has revolutionized the field of regenerative tissue engineering makes it feasible to create personalized corneas. In this study, an artificial cornea with a high degree of precision, smoothness, and programmable curvature was prepared by using digital light processing (DLP) 3D bioprinting in one piece with no support structure, and the construct was then confirmed by optical coherence tomography (OCT). On the basis of this approach, we developed a novel corneal decellularized extracellular matrix/gelatin methacryloyl (CECM-GelMA) bioink that can produce complex microenvironments with highly tunable mechanical properties while retaining high optical transmittance. Furthermore, the composite hydrogel was loaded with human corneal fibroblasts (hCFs), and in vitro experiments showed that the hydrogel maintained high cell viability and expressed core proteins. In vivo tests revealed that the hydrogel might promote epithelial regeneration, keep the matrix aligned, and restore clarity. This demonstrates how crucial a role CECM plays in establishing a favorable environment that encourages the transformation of cell function. Therefore, artificial corneas that can be rapidly customized have a huge potential in the development of in vitro corneal matrix analogs.
Evaluation of surgical fixation methods for the implantation of melt electrowriting-reinforced hyaluronic acid hydrogel composites in porcine cartilage defects
Authors: H. Galarraga Jonathan , M. Zlotnick Hannah , C. Locke Ryan , Gupta Sachin , L. Fogarty Natalie , M. Masada Kendall , D. Stoeckl Brendan , Laforest Lorielle , Castilho Miguel , Malda Jos , Levato Riccardo , L. Carey James , L. Mauck Robert , A. Burdick Jason
Published: June 2023

The surgical repair of articular cartilage remains an ongoing challenge in orthopedics. Tissue engineering is a promising approach to treat cartilage defects; however, scaffolds must (i) possess the requisite material properties to support neocartilage formation, (ii) exhibit sufficient mechanical integrity for handling during implantation, and (iii) be reliably fixed within cartilage defects during surgery. In this study, we demonstrate the reinforcement of soft norbornene-modified hyaluronic acid (NorHA) hydrogels via the melt electrowriting (MEW) of polycaprolactone to fabricate composite scaffolds that support encapsulated porcine mesenchymal stromal cell (pMSC, three donors) chondrogenesis and cartilage formation and exhibit mechanical properties suitable for handling during implantation. Thereafter, acellular MEW-NorHA composites or MEW-NorHA composites with encapsulated pMSCs and precultured for 28 days were implanted in full-thickness cartilage defects in porcine knees using either bioresorbable pins or fibrin glue to assess surgical fixation methods. Fixation of composites with either biodegradable pins or fibrin glue ensured implant retention in most cases (80%); however, defects treated with pinned composites exhibited more subchondral bone remodeling and inferior cartilage repair, as evidenced by micro-computed tomography (micro-CT) and safranin O/fast green staining, respectively, when compared to defects treated with glued composites. Interestingly, no differences in repair tissue were observed between acellular and cellularized implants. Additional work is required to assess the full potential of these scaffolds for cartilage repair. However, these results suggest that future approaches for cartilage repair with MEW-reinforced hydrogels should be carefully evaluated with regard to their fixation approach for construct retention and surrounding cartilage tissue damage.
Updated Review on Treatment of Atopic Dermatitis
Authors: Armario-Hita JC , Galán-Gutiérrez M , Dodero-Anillo JM , Carrascosa JM , Ruiz-Villaverde R
Published: June 2023

Atopic dermatitis (AD) is a chronic or chronically recurrent Inflammatory dermatosis associated with multiple triggers that has a complex pathophysiological mechanism. It is characterized by a heterogeneous clinical expression, signs, and symptoms. Its etiology and pathogenesis are complex and are influenced by multiple immune-mediated factors. Treatment of AD can also be complex, given the high number of available drugs and multiple therapeutic targets. In this review, we summarize current literature on the efficacy and safety of topical and systemic drugs to treat moderate-to-severe AD. We begin with topical treatments such as corticosteroids and calcineurin inhibitors and subsequently address the latest systemic treatments, such as Janus kinase inhibitors (upadacitinib, baricitinib, abrocitinib, gusacitinib) and interleukin (IL) inhibitors, which have proven efficacious in AD, namely, dupilumab (IL-4 and IL-13), tralokinumab (IL-13), lebrikizumab (IL-13), and nemolizumab (IL-31). Given the large number of drugs available, we summarize the pivotal clinical trials for each drug, evaluate recent real-world experience in terms of safety and efficacy for purposes of compilation, and provide evidence to guide the optimal choice of therapy.
Analysis of Speech Anxiety among EFL Learners in Japan: A Comparison between Gender
Authors: Anuardi Muhammad Nur Adilin Mohd , Shamsuddin Wan Noor Farah Wan , Yamazaki Atsuko K.
Published: June 2023

Due to the high encouragement from the Japan Ministry of Education, Culture, Sports, Science, and Technology (MEXT) to promote more internationalization among Japanese graduates, many higher education institutions have started introducing more communicative courses such as public speaking and presentation skills. These goals not only aim to ameliorate students’ communication skills, but also to foster global human resources. Although considerable research has been conducted on students’ communication skills, few have explored the causes of speech anxiety among university students, especially in the context of English as a Foreign Language (EFL). Thus, this study aims to fill this gap by analyzing 43 university students in Tokyo, Japan. According to the results, a pivotal link between gender and speech anxiety was found. Specifically, the female students exhibited higher public speaking anxiety, compared to the male students. This study also investigated the sources of speech anxiety in four domains: communicative apprehension, fear of negative evaluation, test anxiety, and general anxiety of English. Among all four components, the EFL students recorded the highest anxiety in communication apprehension. It is also interesting to note that after completing the presentation skills course, the female students showed a significant reduction in the fear of negative evaluation domain. It is hoped that the findings of this study will be used by instructors to improve EFL students’ communication skills.
Improving Effectiveness of English Medium Instruction Economics Classes: Students' Perceptions in China
Authors: Peng Xuemin , Guo Guihang
Published: June 2023

English Medium Instruction (EMI) is widely implemented in Business English (BE) programs in higher education in China to help students improve English proficiency and master subject matter. Positive impact of EMI on language and content learning has been reported, but using English as the Medium of Instruction (MOI) has also given rise to a number of concerns, such as the loss of subject content and inadequate integration of content and language. To address these concerns, the present study explores the impact of EMI on students’ learning by investigating their perceptions and learning experience of Economics, an EMI core course in the BE program. A questionnaire survey was conducted among 180 BE students to evaluate the pedagogy and teaching quality of the course, revealing improvement areas pertaining to instructional practices and teaching methodology. Based on the findings, the study yields pedagogical implications to improve the quality of EMI and students’ capacity to learn disciplinary content in another language.
Computer Simulation Development for Simulation-Based Learning in High-School Physics
Authors: Krisnadi Dion , Lukas Samuel , Yugopuspito Pujianto , Stefani Dina , Widjaja Petrus
Published: June 2023

COVID-19 has affected how teaching is carried out at all levels of education, including in high school. Teachers must adapt their teaching methods since students can no longer access school’s facilities. This became a concern, especially for subjects that require students to conduct experiments such as Physics. This paper is aimed to design and develop a computer simulation that can be used for simulation-based learning in high-school Physics, particularly on the topic of Newton’s law. The topics covered are constant acceleration linear motion, fraction, and force. Through literature studies, the features of the simulation were determined. The implemented features are interactivity through changeable parameters and immediate visual feedback, three graphics to show the acceleration, velocity, and position of an object, and a Comma-Separated Values (CSV) file that contains the detailed calculations of the simulation for debriefing. The simulation has been developed and evaluated through an online group discussion with two high school Physics teachers. Improvement has been made according to the discussion.
Analysis of Factors Influencing the Employment Motivation of Rural Students in Agricultural Vocational Education – The Example of an Agricultural Vocational School in Chifeng
Authors: Zhang Jiaming , Luan Zhiqiang , Shi Shengpeng
Published: June 2023

In recent years, Chinese national investment in vocational education has increased, especially in rural areas. However, the large amount of investment has not contributed to the promotion of the quality of vocational education. Moreover, the employment of vocational school students is facing serious challenges. The influence of factors such as backward technology, poor working conditions, and low welfare benefits in rural areas has led to the loss of a large number of talents after they have received vocational education, resulting in a serious lack of agricultural high-tech talents in rural areas. This paper uses research and analysis of questionnaires to study rural students in Chifeng on the issue of rural education, discusses the current employment situation of students in agricultural vocational schools, and analyzes the main motives of rural education values on students’ going to rural areas for employment. The results show that 1) the urban orientation, as well as the utilitarianism of rural education, is not significant; 2) the lack of rural content in rural education affects rural students’ future employment region choice, making rural students more inclined to employment in big cities; 3) the employment difficulty of rural students in the city causes the main influence on rural students’ future employment region choice. At the same time, this paper proposes to change the status quo by combining education with information technology.
Overview on Teaching Strategies of Traditional Chinese Historical and Biographical Literature in Vocational Colleges
Authors: Feng Congying , Feng Bin , Wu Guijie
Published: June 2023

Traditional Chinese historical and biographical literature contains rich national spirit. Teaching historical and biographical literature works in the Chinese courses of vocational colleges, guiding students to read these classics in an immersive way, can help them better understand the spiritual code of the Chinese nation. For many reasons, many students in vocational colleges are not very interested in historical and historical literature works, which reduces the teaching effects of traditional Chinese culture. To solve this problem, this paper analyses the current teaching situations of traditional historical and biographical literature works in vocational colleges, expounds the necessity of teaching these works, and proposes the teaching strategies of these works in Chinese courses of vocational colleges based on teaching practice.
Guadalingo in Teaching Spanish as a Foreign Language (FL): Practical Insights
Authors: Costuchen Alexia Larchen
Published: June 2023

The main objective of this study is to provide practical solutions in the teaching of Spanish as a Foreign Language (FL) based on the Common European Framework for Languages (CEFR) in combination with a video game, adapting it to the requirements of L2 language learners. Since video games appeared, they have been increasingly used globally as tools for learning and teaching subjects related with languages, culture, social topics, gender, education, and global citizenship. This article focuses on how to use the serious game Guadalingo and does so through a reflexive approach and using qualitative data. The research was a three-month qualitative study supplemented with numerical values for pre-course information related to participants’ attitude to traditional homework, game-based activities, and device predilection (handheld mobile devices with a touchscreen interface versus PC with a physical keyboard). The findings reveal high presence of female participants and their readiness for playing a video game to learn a new language. Further work is required in the study of motivational out-of-classroom tasks in teaching Spanish with focus on gender (male versus female), age (digital and/or not digital generations), and game graphics.
Dynamic implant navigation system: Enhancing accuracy, safety, and efficiency in implant dentistry
Authors: Madhavan Sankar , Menon Vineetha Venugopal , Johny Joseph
Published: June 2023

Dynamic implant navigation system (DINS), a novel technology that has revolutionized the field of implant dentistry. DINS is a computer-guided system that uses three-dimensional imaging and real-time feedback to aid in the placement of dental implants. The system offers improved accuracy, safety, and efficiency compared to traditional implant placement techniques. This review article discusses the principles and components of DINS, its clinical applications, advantages and limitations, and its future prospects.
A modified open tray direct abutment level impression technique: A clinical tip
Authors: Singh Navdeep , Kumar Saurav , N Thiruvalluvan , Dua Parag , Yangchen Sonam
Published: June 2023

Reproducing the accurate intraoral relationship of an implant through impression making is first step in achieving accurate fit prosthesis. Traditionally impression techniques used in implant dentistry can be classified into closed tray and open tray impression techniques. Open tray impressions are considered to be more accurate as compared to the closed tray impressions in cases with multiple implants. It requires long impression copings which are picked up in the impression during impression procedure thereby reproducing the exact relationship of an implant. Present article describe a modified direct abutment open tray impression technique utilizing applicator tips in absence of long impression copings.
Prosthodontic rehabilitation of patients with Rhinocerebral mucormycosis: An update of evidence
Authors: Pruthi Gunjan
Published: June 2023

Mucormycosis is a devastating disease with serious manifestations in the affected individuals. It spreads through angioinvasion, and the spores have high affinity for olfactory epithelium, and pterygomandibular raphe of immunocompromised patients. Surgical debridement of invaded structures leads to extensive defects, which need prosthodontic rehabilitation to improve the quality of life of the patients. This article is compilation of data presented in literature to showcase the patients who were treated with maxillary obturators to manage post mucormycosis intraoral defects. Lacunae in presentation of clinical cases with future recommendations have also been discussed in brief.
Alopecia Universalis Treated with Ayurveda Protocol and Assessed by SALT (Severity of Alopecia Tool) - A Case Report
Authors: Archana V. , Robin Delvin T. , Mohan Preeti , Chacko James
Published: June 2023

Alopecia Universalis is a condition that causes generalized hair loss in the body. It is associated with nail changes in 10-15 % of Autoimmune origin conditions. Several medicines normalize hair growth, but this condition requires a treatment modality that concentrates on the root cause of hair falling all over the body. Here is a case report about the Ayurvedic approach in a 48-year-old male patient with Alopecia Universalis presented with hair loss all over the body associated with itching. We administered the Ayurveda protocol and Severity of Alopecia Tool (SALT) criteria assumed before and after assessing clinical output.
In Vitro Antioxidant and Anticancer Activity of Plant Extracts of Tanacetum dolicophyllum (Kitam.) Kitam
Authors: Sharma Gunjan , Zaidi Zoya , Ali Mohammad Irfan , Moin Sarmad
Published: June 2023

The objective of this study was the assessment of antioxidant and cytotoxic activity from Tanacetum dolicophyllum. Soxhlet extraction has been used for preparing plant extracts for which five solvents have been used, i.e., Petroleum ether, benzene, ethyl acetate, ethanol, and water. Proteins, tannins, phlobatannins, amino acids, carbohydrates, alkaloids, steroids, flavonoids, glycosides, cardiac glycosides, and phenols were detected in the sample extracts. In the phytochemical screening of plant extracts, ethyl acetate and ethanolic extract show the best results which further leads to the investigation of antioxidant activity. Ferric-Reducing Antioxidant Power (FRAP), 2,2-diphenyl-2-picrylhydrazyl (DPPH), Reducing Power assay, and Phosphomolybdenum assays were performed to estimate antioxidant activity. In the RPA and TAC, the absorbance of sample extracts increases as there is an increase in concentration. In DPPH and FRAP assay, ethyl acetate showed good results. DPPH assay for ethyl acetate extract with 172.73(µg/ml) and ethanolic extract with 171.07(µg/ml) of IC50 values. The ethyl acetate extract had the highest antioxidant activity. The MTT assay was used to investigate the anticancer activity. The MTT assay discovered that the ethyl acetate extract had the highest anticancer activity against HeLa cells with an IC50 75 µg/mL as compared to a normal cell line J774A. Several compounds present in the extract of ethyl acetate acted as anticancer and contributed to cytotoxic activity.
Assessment of Anxiolytic Activity of Brahmi (Bacopa monnieri) in Zebrafish Model System
Authors: Mudgal Padmshree , Gupta Radhika , Joshi Adita , Prakash Chandhana , Gupta Kajal , Sachdeva Ritika , Joshi Niharika
Published: June 2023

The increasing prevalence of anxiety and stress-related disorders has made it a leading contributor to the global health burden. The present treatment options have severe side effects and show remission on discontinuation of the medication. Hence, there is an urgent need to explore safer alternative treatments for long-term usage with minimum toxicity. The medicinal plant Brahmi (Bacopa monnieri) has been used in Indian traditional medicine as a neural tonic for centuries. The present study aimed to study the toxicity and anxiolytic activity of Brahmi using the zebrafish model system. The toxicity assays determined the minimum effective concentration of Brahmi to be 0.01%. In addition, behavioral assays such as thigmotaxis and scototaxis and endocrine assays such as the measurement of cortisol levels in stressed zebrafish larvae were performed. Zebrafish embryos exposed to 0.2% Brahmi up to seven days post fertilization (dpf) did not show any developmental toxicity. Behavioral and endocrine assays were performed on 5dpf zebrafish larvae treated with 0.01% Brahmi extract. Our studies show that Brahmi significantly reduced thigmotaxis (wall hugging) and scototaxis behavior in zebrafish larvae exposed to osmotic stress as compared to untreated stressed larvae. Stress activates the hypothalamic-pituitary-interrenal axis and stimulates the release of cortisol in zebrafish larvae. Whole body cortisol assay has shown that Brahmi significantly reduced the stress-induced release of cortisol in zebrafish larvae. Our studies report that Brahmi mitigates the stress response in zebrafish larvae and has minimum toxicity. This suggests that Brahmi may be a safe option for long term management of stress.
Physicochemical Characterization and Cytocompatibility Study of Lyophilized Cow Urine Powder
Authors: Pallawi  , Vishwakarma Neeraj K. , Paulraj Sushmitha , Kumar Mahto Sanjeev , Singh Kameshwarnath
Published: June 2023

Cow urine is known for possessing therapeutic potency which is found to vary depending upon its physical forms such as fresh sterile urine, distillate, lyophilized powder, etc. In the current work, we demonstrate the physicochemical characteristics and cytocompatibility of lyophilized powder of cow urine obtained from Sahiwal and the pure Indian breed. We have used several analytical techniques, including Thermogravimetric Analysis (TGA), Fourier Transform Infrared (FTIR) Spectroscopy, Differential Scanning Calorimetry (DSC), Nuclear Magnetic Resonance (NMR) spectroscopy and Scanning Electron Microscopy – Energy Dispersive X-ray Spectroscopy (SEM-EDX) to examine the physical and chemical nature of cow urine powder obtained through lyophilization. SEM-EDX analysis showed clusters like morphology and revealed 25-30% of metal ions present in both samples. TGA analysis showed three steps of degradation sequentially most likely due to initial desorption of adsorbed water, urea degradation, and loss of glycoside moiety present in flavonoid. DSC data revealed the presence of both irregular (amorphous) and ordered molecular structures (crystalline) in the lyophilized powder of cow urine. 1H NMR spectra of all the prepared cow urine samples exhibited a similar trend and did not vary significantly and; confirming the presence of the same flavonoid/compounds in each sample. FTIR spectra of all the prepared cow urine samples exhibited a similar trend and did not vary significantly as observed through 1H NMR spectra. In addition, a cytocompatibility study and MTT assay using NIH-3T3 fibroblast cells revealed that lyophilized cow urine powders possessed no deleterious effects on healthy fibroblast cells. Thus, the outcomes provide a benchmark for further understanding of the lyophilized form of cow urine that could be potentially useful for analyzing its therapeutic value.
Ayurveda Treatment Protocol in the Management of Relapse of Palmo-Plantar Pustulosis (PPP) - A Case Report
Authors: Chacko James , Varshanath B. , Robin Delvin T. , Mohan Preethi
Published: June 2023

Background: Palmo-Plantar Pustulosis (PPP) is one of the debilitative skin disorders having a prevalence of 0.050 to 0.12 % worldwide, which is hallmarked by sharply demarcated erythematous pustular lesions over the body. Modern treatment provides certain moisturizers, topical steroids, light therapy, and systemic therapies in the long run, but recurrent crops of pustular lesions are the main problem. Here a case of PPP treated with Ayurvedic protocol is discussed. A 65-year old female patient complained of blackish-red pustular desquamative lesions over the upper and lower limb associated with occasional oozing after itching with extreme hardness and rough texture over the affected area for three years. The ailment was diagnosed as kitibha (a type of psoriasis), and the treatment was organized accordingly. The patient received continuous virechana (purgative therapy) for three months at a rate of six days per month, followed by pathya (wholesome food), topical application, and internal medications. Auspitz signs and PASI (Psoriasis Area and Severity Index) assessment, along with symptomatic improvement in signs and symptoms, were used to quantify the outcome of the disease. After receiving the initial bowel cleansing medications such as Patolakaturohinyadi Kashaya, Saribadyasava, and Manibhadragula, the patient claimed complete recovery from the acute phase. The second phase was followed by continuous virechana (purgation therapy) for three months at a rate of six days per month, which showed no signs of relapse for three consecutive months in the affected areas. Even though PPP is incredibly challenging to treat, shodhana (purificatory therapy) for six consecutive months can potentially prevent relapse. This opens up the future scope for structured clinical trials in the treatment of disease.
Detection of Antibacterial Activity of Garlic Against Acinetobacter Species Isolated from Patients in Tertiary Care Hospital
Authors: Rao Sareena , Naik Deepashri
Published: June 2023

The aim of the present study evaluates the antibacterial activity of garlic extracts on isolates of Acinetobacter. A total of 100 strains were collected from various samples at MGM hospital in Kamothe, Navi Mumbai. The susceptibilities of isolates to different antibiotics were tested by using the Kirby Bauer agar disk diffusion method. Seventy-nine per cent of isolated strains showed resistance to at least 14 or more antibiotics and all strains are multidrug resistant. Antibacterial activity of different concentrations of Garlic Extract was measured by well diffusion and the disk diffusion method. Garlic extract was used in the range of 5% to 100%. The present study suggests that multidrug-resistant Acinetobacter bacteria with significant antibiotic resistance show significant susceptibility to modest amounts of garlic extracts.
Antidiabetic Activity of Vasant Kusumakar Ras in Streptozotocin and High Fat Diet Induced Type 2 Diabetes Mellitus in Sprague Dawley Rats
Authors: Gaidhani Sudesh N. , Ala Srikanth , Reddy Viswanth , Sanjaya Kumar Y. R. , Jamadagni Shrirang , Selvam Thamizh , Ajeesh Kumar K. K.
Published: June 2023

Background: VasantKusumakar Ras (VK Ras) is a traditional Ayurvedic preparation used in the treatment of Type-2 diabetes mellitus. Despite its clinical anti-diabetic claims, no pre-clinical attempts were made to rule out its efficacy as an antidiabetic agent. Objectives: The present study was carried out to find the anti-diabetic effect of VK Ras against a High-Fat Diet (HFD), and low-dose streptozotocin (STZ) induced type 2 diabetes and to explore the mode of action of VK Ras. Materials and Methods: Different doses of VK Ras were administered to diabetic rats for 35 days. The biochemical markers analysis, intestinal glucose uptake, and liver glycogen content were estimated at the end of the study and also vital organs were weighed and subjected to histopathological evaluation. Results: VK Ras treatment reduced blood glucose in a dose-dependent manner. The insulin, HbA1C, HOMA-IR, and lipid profiles were improved in VK Ras-treated animals as compared to diabetic control animals. The relative organ weights were changed in diabetic rats, and treatment with VK Ras corrected the organ weights. Intestinal glucose uptake and liver glycogen content were decreased with treatment. Further, the histopathological analysis of the pancreas and other vital organs had shown that dose-dependent restoration of organ function with VK Ras treatment. Conclusions: VK Ras treatment reduces insulin resistance as well as corrects the lipid, hepatic and renal abnormalities that arise from diabetes, these effects may be mediated by interfering with glucose transport from the gut and insulin release from the β pancreatic cells.
A Review on the Potential Anti-inflammatory Properties of Kappaphycus alvarezii
Authors: Shihab Silva , Jacob Anu , Mathew Jissin , Ann Mathew Alina , Shanamitha A.
Published: June 2023

Inflammation is significant innate mechanism of immunity in our human system. It enables our body to respond to a variety of stimuli, including ischemic, traumatic, physical, chemical, and infectious impulses. A major contributor to global health challenges and a significant driver of rising health expenditures are inflammatory disorders. Naturally occurring substances as well as its chemical structural analogues with anti-inflammatory potential have been discovered in the recent years. Marine life forms have a myriad source of natural molecules that can invoke inflammation as a defense against pathophysiology of illness. Macro and microalgae have been determined to be an undiscovered resource with pro-and anti-inflammatory compounds. Natural substances found in marine species can be employed in novel interventions as treatment modalities as anti-diabetic, anti-inflammatory, anti-bacterial, anti-viral, and antioxidant capabilities. Among these substances, Kappaphycus alvarezii is one such marine red algae that can be employed therapeutically to possess biological effects that exhibit strong anti-inflammatory activity and fewer adverse effects. The expanding desire to research marine seaweeds such as Kappaphycus alvarezii and its phytochemicals has made it possible to find novel substances with the potential to be used in healthcare in the near future. This review envisages the anti-inflammatory properties of marine algae along with phytochemicals discovered in Kappaphycus alvarezii and its biological functionalities.
Anti-obesity and Antihyperlipidemic Activity of Ougeinia oojeinensis (Roxb.) in High Fat Diet-Induced Obesity in Experimental Animals
Authors: Jagadeeshwar K. , Subhakara Raju R. , Chakravarthi G. , Rajasekhar Reddy A. , Koteswara Rao G. S. N. , Malothu Narender
Published: June 2023

The present study was planned to assess the anti-obesity efficacy of petroleum ether, ethyl acetate, and methanolic extracts of leaves of Ougeinia oojeinensis (Roxb.) belonging to the family Fabaceae. The soxhlation method was employed to produce the extracts. Wistar rats were subjected to a high-fat diet for 40 days to induce obesity. Along with the high-fat diet, a standard drug Orlistat 50 mg/kg and various extracts of O. oojeinensis at 100 mg/kg and 200 mg/kg were administered for 40 days. The key markers like lipid profiles, SGOT, SGPT, glucose, body weight, food intake, body temperature, atherogenic index, coronary index, and weight of the organs were assessed. The anti-antioxidant properties like TBARS, GSH, GR, Gpx, SOD, and CAT were also estimated. The results revealed that O. oojeinensis with the doses 100 and 200 mg/kg showed significant Anti obese and hypolipidemic effects in rats fed with a high-fat diet.
Developing Cost-Effective and Efficient Drinking Water Treatment Technology for the Removal of Salinity and Suspended Solids
Authors: Jansi Rani P. G. , Vimala C. , Divya T. , Anusha M. B. , Vinotha T. , Rajagowri J. , Shanmugam Kumaran
Published: June 2023

Although a variety of economical water treatment options are available, rural residents struggle to have safe drinking water. Therefore, developing cost-effective and efficient drinking water treatment technology for the removal of selected ionic compounds and suspended solids is necessary. The present study aims to establish a cost-effective water treatment method by employing the following adsorbents Graphene Sand Composite (GSC), GSC with Moringa Oleifera seeds, Phyllanthus emblica seeds, Strychnos potatorum seeds, tea waste, sawdust, coal, coconut charcoal, and clay pot (an indigenized filter). X-ray diffraction of GSC confirms SiO2 nanoparticles, a broad peak centred at 22.5°, Graphene peaks are found at 26.73 (200), 45.8 (110) and 54.959 (222). In FT-IR, graphene oxide has a strong and wide O-H/ Si-OH stretching vibration peak at 3444 cm-1. In the Raman spectrum, the graphitic vibration band from its first-order scattering of E2g photons using sp2 carbon appeared at 1589 cm-1. Moreover, the graphitic vibration band contributes to the presence of stretching C-C bond; which is common in all sp2 carbon systems. Water’s pH, TDS, hardness, and chloride content also increased considerably in a few adsorbents. Fabricated pots with an indigenous filter using GSC and Moringa oleifera seed as filter disc has also been designed and evaluated in the present study. In this research, 100% salinity removal is achieved using GSC as an adsorbent. While there is an interesting rise trend in fluoride and calcium content to 33% and 39%, respectively. The reason for the rise in fluoride and calcium can be studied further.
Treatment of Extra-gingival Pyogenic Granuloma (Athara ratthathontham) in Siddha – A Case Report
Authors: Jeyavenkatesh J. , Roja Ramani S.
Published: June 2023

The present case report was a 36-year female with lesion on the right side of inner lower lip and diagnosed as pyogenic granuloma occurring at an unusual site. The presently available treatment for pyogenic granuloma is surgical excision which might delay the wound healing due to complications such as intraoperative bleeding and post operative infection. Other treatment modalities such as cryosurgery, CO2 and Nd:YAG lasers, flash lamp pulsed dye lasers, surgical ablation, and radiation may not be affordable for many patients. In our present study, the Siddha para-surgical therapy chuttigai (cauterization) was performed and the case was followed up for 30 days. The intervention was found to be as a simple, inexpensive therapy effective in treating small superficial pedunculated vascular lesions with no blood loss or no need of hospitalization.
Alleviating Potential of Zingiber officinale and Cow Urine Distillate Co-administered with Levetiracetam in Epileptic Rats: A Pharmacokinetic and Pharmacodynamics Approach
Authors: Solanki Nilay , Patel Harshal , Patel Milap , Patel Yamini , Shukla Preetu , Kakadiya Jagdish , Maheshwari Rajesh , Chauhan Priyal
Published: June 2023

Background: Epilepsy is a severe neurological condition that affects all ages of people. Complex pathways involved in pathogenesis make it complicated to treat; selected antiepileptic drug options are available for Epilepsy. There is a need for an hour to develop novel treatment approaches for epilepsy with lesser side effects. This research aimed to evaluate the alleviating role of bio-enhancers co-administered with levetiracetam for pilocarpine-induced epilepsy. Methodology: Pilocarpine (250 mg/kg) was used to develop epilepsy in rats. Levetiracetam (LEV) (140 mg/kg) was administered with Zingiber officinale Extract (ZOE) (15 mg/kg and 30 mg/kg) and Cow Urine Distillate (CUD) (1.5 ml/kg and 3 ml/kg). HPLC was used to evaluate drug concentration in blood. Serum nitrate, catalase, CRP, calcium level and calcium level of the brain, behavioural markers in rats were assessed and compared with the Leviteracetam group only. Result and Discussion: The present study showed that combining ZOE and CUD with levetiracetam was advantageous through substantial reduction (p < 0.05) in serum nitrate, CRP and increased catalase (p < 0.05), while reduced serum calcium compared to LEV alone. Combination of ZOE and CUD with levetiracetam treatment also reduced seizure behaviour and duration in rats. The bioavailability of LEV in plasma and brain was increased when epileptic rats were treated with LEV plus ZOE and CUD compared to disease control. Conclusion: Utilization of Zingiber officinale and CUD in combination with LEV was proven therapeutically effective in the epileptic model and used to lower the dose of LEV along with reducing seizure behaviour and time with the potential for the treatment of epilepsy.
Организация прокурорского надзора за исполнением законодательства об образовании
Authors: Маказиева З.Д , Бецилаев А.М
Published: June 2023

Настоящая научно-исследовательская статья посвящена анализу организации прокурорского надзора за исполнением законодательства об образовании, как основополагающего аспекта надзорной деятельности государства. Автором в научно-исследовательской статье раскрываются все сущностные аспекты организации прокурорского надзора за исполнением законодательства об образовании, с приведением конкретных примеров из надзорной деятельности, а также систематизируются перспективы развития обозначенного направления прокурорской деятельности.
Некоторые вопросы назначения судебных экспертиз по делам о подлоге документов
Authors: Палазин С.А.
Published: June 2023

Работа направлена на рассмотрение некоторых вопросов назначения судебных экспертиз по делам о подлоге документов. Судебная экспертиза по делам о подлоге документов является важным этапом в расследовании преступлений, связанных с подделкой или изменением документов. В данной статье рассматриваются некоторые вопросы, связанные с назначением судебных экспертиз в таких делах. Для исследования данной проблемы был проведен обзор литературы, включающий анализ законодательства, судебной практики и научных статей по данной теме. Также были проанализированы результаты интервью с экспертами и представителями суда. Результаты исследования могут быть полезны для судебных органов и экспертов, а также для юристов и иных специалистов, занимающихся правовыми вопросами
Анализ проблем правового регулирования деятельности в области обращения с отходами
Authors: Хабиева З.Д.
Published: June 2023

Настоящая научно-исследовательская статья посвящена анализу проблем правового регулирования деятельности в области обращения с отходами, как основополагающего аспекта экологического права. Автором в научно-исследовательской статье раскрываются все коллизионные и противоречивые аспекты регулирования деятельности в области обращения с отходами, с приведением конкретных примеров из практики обращения с отходами в Российской Федерации, а также систематизируются перспективы развития обозначенного направления.
Организация земской книготорговли в Воронежской губернии в конце XIX – начале XX века
Authors: Жегульская Т.Ю
Published: June 2023

В данной статье автор анализирует начальный этап деятельности земств Воронежской губернии по распространению книг среди крестьянского населения в конце XIX – начале XX века.
Позиция Конгресса США по вопросу принятия плана Маршалла в 1948 г.
Authors: Малышева Н.С.
Published: June 2023

Статья посвящена рассмотрению Конгрессом США программы экономической помощи, или плана Маршалла, разработанного американским правительством для восстановления экономики стран Западной Европы. Отмечается, что утверждение плана Маршалла было осложнено преобладанием в составе Конгресса депутатов от Республиканской партии, находящейся в оппозиции сформированному Демократической партией правительству. Несмотря на это, обсуждение программы и ее утверждение Конгрессом продемонстрировало способность американских политических сил договариваться по внешнеполитическим вопросам в условиях Холодной войны.
Утомление организма после физических нагрузок и мероприятия для его восстановления
Authors: Проскурина Е.Ф. , Ефимако А.А.
Published: June 2023

Представленная исследовательская работа посвящена вопросу утомления организма человека после физических нагрузок и способов его устранения. Авторами рассмотрены теоретические аспекты данного явления и представлена классификация степени утомления вследствие занятий спортом. Также, сформулировано понятие восстановительного процесса и перечислены мероприятия, способствующие предотвращению физической утомляемости.