bluuebunny/crossref_metadata_2025 huggingface dataset:
Aspectos de las ciencias OMICs en la neurobiología del comportamiento agresivo humano
Authors: Sousa Gutemberg Delfino de , Oliveira Marcia Silva de
Published: December 2024

La comprensión del comportamiento humano se basa en conceptos patogénicos, terapias empíricas y enfoques neuropsicofarmacológicos, involucrando neurotransmisores como noradrenalina, dopamina, serotonina y el tratamiento de patologías subyacentes incluye psicofármacos, antipsicóticos e inhibidores selectivos, cuya efectividad ha sido limitada, lo que denota la participación de otras vías en el proceso patogénico. Estudios basados en ciencias ómicas (biología molecular, metabolismo, factores transcripcionales, genética y epigenética) demuestran varios genes y procesos genéticos de metilación y reparación del ADN implicados en la patogénesis de estas enfermedades. El objetivo de este artículo es presentar un estudio de revisión sistemática sobre los principales aspectos de las ciencias ómicas que pueden contribuir a la comprensión de los mecanismos moleculares del comportamiento agresivo humano, dada su presencia en la mayoría de los trastornos psiquiátricos. El conocimiento molecular de estos procesos revela una superposición de fundamentos genéticos y epigenéticos que pueden proporcionar información útil para el estudio, diagnóstico, predicción u investigación terapéutica de los mecanismos del comportamiento agresivo humano.
A importância da suplementação de creatina na prática de esportes: Uma revisão de literatura
Authors: Faria Enzo Ramirez Tom Back , Silva Maria Cláudia da
Published: December 2024

A creatina, considerada uma substância endógena, é sintetizada pelo organismo e pode ser obtida por meio da alimentação, sendo amplamente utilizada como suplemento, especialmente por indivíduos que praticam exercícios físicos e atletas. Estudos indicam que a suplementação de creatina pode aumentar a capacidade muscular e promover o ganho de massa magra. Seu efeito ergogênico está relacionado ao aumento dos níveis de fosfocreatina nos músculos, melhorando a regeneração energética durante atividades de alta intensidade e otimizando a resistência muscular. Os resultados da revisão indicam que a suplementação de creatina contribui positivamente para a hipertrofia muscular, o metabolismo energético durante o exercício e a recuperação pós-exercício. A combinação de creatina com carboidratos demonstrou potencial para otimizar sua absorção, por meio do aumento dos níveis de insulina, favorecendo a captação muscular de nutrientes. Essa interação também apoia o desempenho físico e a recuperação pós-exercício. Apesar de seu uso ser considerado seguro em doses adequadas, o consumo excessivo ou sem orientação pode causar efeitos adversos, como fadiga muscular e desidratação. Estudos ressaltam a importância de protocolos específicos e da supervisão de profissionais de saúde para o consumo seguro de creatina. Embora os efeitos a longo prazo ainda necessitem de mais investigações, a suplementação adequada pode maximizar benefícios enquanto minimiza riscos. O uso responsável da creatina se mostra essencial, tanto para melhorar o desempenho físico quanto para evitar potenciais impactos adversos.
Miopatia induzida por corticoides em uma paciente com Síndrome de Sjögren: Relatório de caso e revisão de literatura
Authors: Rodrigues Bruna Maria Fernandes , Moreira Giovanna Gonçalves , Oliveira Lilia Beatriz
Published: December 2024

A miopatia induzida por glicocorticoides é uma doença tóxica causada pela administração exógena desses fármacos, seja por via oral ou intravenosa. Clinicamente, caracteriza-se por fraqueza e baixa resistência da musculatura esquelética. O objetivo desse artigo é informar aos leitores sobre como o uso de corticoides por um longo período de tempo pode acarretar no surgimento da miopatia, identificando como isso afeta a qualidade de vida do paciente. O presente estudo expõe o relato de uma paciente com diagnóstico de Síndrome de Sjögren que apresentou complicações de sua patologia, o que exigiu o uso de corticosteroides. Após a administração da medicação, a paciente desenvolveu fraqueza muscular nos membros inferiores. Com base na associação entre o quadro clínico, exames laboratoriais e eletroneuromiografia, a principal hipótese diagnostica para a paciente relatada foi miopatia induzida por corticoides.
Adesão a exercícios de moderada a alta intensidade em pacientes com fibromialgia: Uma revisão narrativa sobre os fatores fisiológicos e psicológicos envolvidos
Authors: Silva Gabriel Silva da , Lima Worney Gabriel Aranha de , Moreira David Washington dos Santos , Silva Maria Regiane Ferreira da , Viana Joaquim Albuquerque , Boaventura Alessandra Bárbara César de Freitas
Published: December 2024

O presente estudo tem como objetivo investigar os efeitos do treinamento funcional sobre o equilíbrio e o sistema propriocetivo em indivíduos com deficiência visual. É fundamental destacar que as pessoas com deficiência visual enfrentam dificuldades específicas e diversos desafios, especialmente no que diz respeito à qualidade de vida, dado que sua perceção visual do ambiente é bastante reduzida. Essa limitação compromete a capacidade de realização de atividades diárias de forma autônoma, impactando diretamente sua qualidade de vida. Nesse contexto, o treinamento funcional surge como uma alternativa promissora para melhorar o equilíbrio e o sistema propriocetivo em indivíduos com deficiência visual, promovendo, assim, uma melhor qualidade de vida. Para alcançar os objetivos propostos, realizou-se uma revisão bibliográfica narrativa, fundamentada em estudos teóricos relacionados à temática abordada. A pesquisa utilizou bases de dados reconhecidas, como LILACS, BVS, CAPES e SciELO, para compor o referencial teórico e metodológico do estudo. O estudo concluiu que o treinamento funcional promove melhorias no equilíbrio, na propriocepção e na coordenação motora de pessoas com deficiência visual, contribuindo para sua autonomia e prevenção de quedas.
Revascularização pulpar de dentes permanentes necróticos imaturos: Uma revisão integrativa
Authors: Santos Larissa Barros dos
Published: December 2024

A revascularização pulpar apresenta vantagens significativas em relação às técnicas tradicionais. Enquanto os métodos convencionais, como a obturação, focam na contenção do problema removendo a polpa e selando o canal, a revascularização busca preservar ao máximo o tecido saudável e estimular a regeneração biológica. Sendo assim, o estudo tem como objetivo realizar uma revisão da literatura sobre a revascularização pulpar de dentes permanentes necróticos imaturos. Desta forma, restaram 10 artigos para análise desta revisão. A revascularização pulpar de dentes permanentes necróticos imaturos é uma abordagem regenerativa que promove o fechamento apical e a continuação do desenvolvimento radicular, além de restabelecer a funcionalidade da polpa. Sendo assim, pesquisas científicas correlacionam essa técnica com resultados clínicos promissores, destacando suas vantagens sobre métodos tradicionais, como a apexificação, ao proporcionar uma abordagem menos invasiva e biologicamente orientada. Apesar dos avanços significativos, a técnica ainda enfrenta desafios, como a padronização dos protocolos e a redução de efeitos adversos associados ao uso de medicamentos intracanais. Estudos futuros devem explorar abordagens que equilibrem eficácia e segurança, além de investigar o impacto de variáveis individuais, como idade e condição inicial do dente. Dessa forma, a revascularização pode consolidar-se como a principal escolha para dentes com essa condição, contribuindo para melhores prognósticos clínicos e ampliando o arsenal de técnicas regenerativas na endodontia moderna.
The THE IMPLEMENTATION OF ARTICLE 66 ENVIRONMENTAL PROTECTION AND MANAGEMENT LAW OF STRATEGIC LEGAL ACTION AGAINST PUBLIC PARTICIPATION DUE TO CRIMINAL ACTS OF ENVIRONMENTAL DESTRUCTION AT STATE COURT
Authors: Sariroh ST. , Ali Mohammad
Published: December 2024

Environmental problems are increasingly diverse in all regions from small scale to serious large scale. Article 66 reporting on allegations of environmental pollution will be protected by the state. However, the current reality is that the victims are getting worse, deprived of rights and no legal protection by a party in the legal efforts taken. Researchers will examine more deeply the views of judges as law enforcers regarding the existence of Article 66. This empirical research used normative-descriptive, by describing the judges' opinions on the implementation of Article 66 on Strategic Legal Action Against Public Participation and analyzed with an Administrative Law Perspective. The study results indicate that the judge believes there are still few reports or lawsuits on environmental cases because Jember is not yet a large-scale industrial area. By law, article 66 is a form of protection that must be implemented properly. However, it must be careful and accommodate all existing values. Because the judiciary cannot reject every registered lawsuit.
NILAI FILOSOFIS KACAR KUCUR DALAM PERKAWINAN ADAT JAWA PERSPEKTIF AL-‘ADAH AL-MUHAKKAMAH DI DESA KERAS KABUPATEN JOMBANG
Authors: Alkhusni Muhammad Fatih , Kusumawati Ita Rahmania , Mu’allim Much.
Published: December 2024

Pelaksanaan adat kacar kucur dalam konteks pernikahan Jawa, yang merupakan tradisi turun-temurun dengan makna mendalam. Adat ini melibatkan pengantin pria yang menuangkan biji-bijian, rempah-rempah, dan uang logam ke pangkuan pengantin wanita, melambangkan tanggung jawab suami dan simbolisasi kasih sayang. Nilai filosofis yang terkandung dalam prosesi ini mencakup pengayoman, ketenangan, dan penghormatan antara suami dan istri, serta peran penting orang tua dalam membimbing pasangan pengantin. Dalam perspektif al-‘adah al-muhakkamah, kacar kucur dianggap tidak bertentangan dengan hukum Islam, sehingga eksistensinya tetap terjaga dalam masyarakat modern. Penelitian ini menekankan bahwa adat kacar kucur bukan hanya sekadar tradisi, tetapi juga mencerminkan nilai-nilai spiritual yaitu yang terdapat dalam al-qur’an surat an-nisa’ ayat 34, bahwa “Pria (suami) adalah pemangku pada tiap-tiap Wanita (istri) dikarenakan Allah sudah memperbesar mayoritas mereka (pria) pada mayoritas yang lain (wanita) dan sebab itu mereka (pria) sudah menafkahkan bebrapa dari kekayaannya.
Kata Kunci: filosofi, kacar kucur, adat jawa, al-‘adah al-muhakkamah
 
ABSTRACT
Implementing the Kacar Kucur custom in the context of Javanese weddings, which is a tradition passed down from generation to generation with deep meaning. This custom involves the groom pouring grains, spices, and coins into the bride's lap, symbolizing the husband's responsibilities and symbolizing affection. The philosophical values ​​contained in the process include protection, calm and respect between husband and wife, as well as the important role of parents in guiding the bridal couple. In the perspective of al-'adah al-muhakkamah, kacar kucur is considered not to conflict with Islamic law, so its existence is maintained in modern society. This research emphasizes that the Kacar Kucur custom is not just a tradition, but also reflects spiritual values, namely those contained in the Al-Qur'an, Surah An-Nisa' verse 34, that "Men (husbands) are the guardians of every woman ( wives) because Allah has enlarged their majority (men) over the majority of others (women) and because of that they (men) have spent some of their wealth.
 
Keywords : philosophy, kacar kucur, Javanese customs, al-'adah al-muhakkamah
Nivel de prevención ante el delito de extorsión y la seguridad ciudadana
Authors: Huaman-Ruiz Lesvy
Published: December 2024

Esta investigación tiene como objetivo evaluar el nivel de prevención ante el delito de extorsión y su influencia en la seguridad ciudadana en la ciudad de Lima. La investigación es de tipo aplicada, nivel evaluativo y el diseño es no experimental ya que no se manipularon las variables de estudio. La población estuvo conformada por los magistrados y ciudadanos, la muestra la representaron 10 Jueces en lo Penal, 19 Fiscales Penales y 31 abogados especializados en Derecho Penal del Distrito Judicial de Lima; la técnica aplicada fue la encuesta y el instrumento el cuestionario, validado por expertos en el área. Como resultados, se muestra con un nivel de significación a= 0,05 (con 95% de confianza), que el nivel de comunicación y difusión en la prevención ante el delito de extorsión, el nivel de conocimientos sobre las temáticas de riesgo y el manejo de estrategias de seguridad influyen significativamente en la seguridad ciudadana en la ciudad de Lima. Se concluye que el Nivel de prevención ante el delito de extorsión influye significativamente en la seguridad ciudadana en la ciudad de Lima.
Impresszum
Authors: Sántosi Péter
Published: December 2024

Impress
Podological Analysis in Children with Neuromotor Disabilities
Authors: Tedeschi Roberto
Published: December 2024

Background. Pediatric patients with neuromotor disorders often present with a variety of podiatric conditions. Despite the use of treatments like orthotics and insoles, the effectiveness of these interventions in managing associated foot problems is not well understood.
Aim. This study aims to evaluate common podiatric issues in children with neuromotor disorders and to assess the associations between these conditions and various interventions, such as orthotics, insoles, and surgeries.
Methods. An observational study was conducted with 20 pediatric patients (aged 4–16 years) diagnosed with neuromotor disorders, including cerebral palsy, idiopathic toe walking, and genetic syndromes. Podiatric conditions such as ingrown toenails, hyperhidrosis, and toe walking were documented. Chi-square tests were used to determine the relationships between treatments and podiatric conditions
Results. Orthotic use was significantly associated with ingrown toenails (χ² = 5.69, p = 0.017). Insole usage was linked to increased hyperhidrosis (χ² = 4.44, p = 0.035), while orthotics were more prevalent in patients who had undergone Achilles tendon lengthening (χ² = 8.15, p = 0.017). Common podiatric issues included hyperkeratosis (30%), ingrown toenails (40%), and toe walking (40%).
Conclusions. The aim of this study was to describe the podiatric issues of the foot in children with neuromotor disorders. The findings reveal a high prevalence of conditions such as ingrown toenails, hyperkeratosis, and toe walking. The study also identifies associations between these conditions and the use of orthotics, insoles, and surgical interventions, demonstrating that while these treatments are common, they may sometimes exacerbate certain conditions. This underscores the importance of regular, individualized podiatric care to manage and mitigate these issues effectively. However, further research with larger sample sizes and long-term follow-up is necessary to fully understand the impact of these interventions and develop optimized care strategies.
Keywords: neuromotor disorders; podiatric conditions; pediatric patients; foot health; podiatrists.
Introduction: Gothic Age and Ageing
Authors: Aaron Green James , Paulo Guimarães João
Published: December 2024

In this introduction to the special issue, the editors sketch the major talking points within the recent turn towards examining Gothic fiction through the lens of age and ageing, and vice versa. They consider how the mode’s concern for the return of the past is readable as an anxious treatment of intergenerational relations, which are shown to contain the potential for coercion and exploitation. Gothic fiction brings to the fore the worrisome significations of old age in global societies that increasingly see age as a matter of productive output. The gothic figure of the vampire in particular reworks the archetypes of the ‘burdensome’ and ‘rapacious elder’, but in all cases (including the child-vampire) gains its threat and appeal from inverting age-based expectations. The mode also purposefully represents old age and ageing as abject or gruesome, foregrounding an uncomfortable possibility famously explored in Simone de Beauvoir’s La Vieillesse (1970); attempts to reverse or annul the ageing process receive similar treatment. The Introduction concludes with an overview of the contributions. Diverse in their subjects, and spanning the mode’s eighteenth-century origins through to its twenty-first century effusions, the essays nonetheless jointly evidence that age and ageing are integral to the form and function of the Gothic.
The Ages of Capital: The Dialectic of Undead Rejuvenescence and Ossification
Authors: Althofer Jayson , Musgrove Brian
Published: December 2024

In Capital (3 vols, 1867–1894), Karl Marx personified Capital in gothic terms through a series of disordered ages whose shifting appearances defy natural ageing processes. He imaginatively represented capitalist derangements of age and ageing, portraying Capital as a perpetual newborn, strange god, machinic monster and undead vampire, whose inner drive to immortality violently disjoints, shortens and sacrifices human life. This article examines Marx’s portrayal of Capital’s Bildung as daily and eternally youthful, god-like, monstrous and verrückt (crazy and deranged). It argues that Capital’s incessant rejuvenescence and its ossification and obliteration of life are inseparable processes, dialectically united, of its living-dead ageing. The article conceptualises the gerontological unconscious of capitalist society and demonstrates how Gothic Marxism can unfold the class struggles inhering in motifs of ageing and non-ageing shared by Capital and the Gothic. These include monstrous birth and rejuvenation, torturously foreshortened life, premature senescence, and vampiric longevity and immortality.
UMA INTERPRETAÇÃO FOUCAULTIANA DO NEOLIBERALISMO
Authors: Vieira Luan
Published: December 2024

Visamos apresentar uma interpretação sobre a perspectiva de Michel Foucault sobre o neoliberalismo, e, em específico, destrinchar certos aspectos de seu curso “O Nascimento da Biopolítica” (2008), como a sua metodologia, sua instrumentalização teórica e seus fundamentos conceituais, para, enfim, propor reflexões e práticas a partir da compreensão foucaultiana do neoliberalismo. De início, centralizamos nossa investigação na metodologia de Michel Foucault e, em nosso desenvolvimento, realizamos uma série de relacionamentos entre conceitos e interpretações do filósofo francês para desenhar uma configuração do neoliberalismo com ênfase na constituição do indivíduo neoliberal e nos aspectos estruturantes de uma sociedade neoliberal; por fim, concluímos que a resistência, para Foucault, pode ser interpretada a partir de paralelos com a sua metodologia, isto é, ambos compartilham o princípio de privilegiar práticas concretas.
A FENOMENOLOGIA DE HUSSERL
Authors: Portes Luan Marcos
Published: December 2024

Resumo: A presente pesquisa expressa o método fenomenológico proposto por Edmund Husserl (1859-1938). Entende-se o método fenomenológico desenvolvido por Husserl, como exegese da capacidade do homem conhecer e fazer ciência do mundo percebido. Por meio da redução Fenomenologia e eidética, cogitou-se vislumbrar e apontar as raízes da autêntica condição do homem perante a realidade que lhe é verdadeiramente revelação, e o dado da experiência reflexiva da consciência como expressão última da realidade íntima do homem, na correlação entre a atitude da consciência e os dados que a ela se anunciam como essências reais. A ciência, a partir da abordagem feita por Husserl,  mostrou ter como solo último a pura experiência do ser consciente que se coloca diante do mundo que se lhe oferece como realidade em si, por meio do desvelamento que o Eu consciente faz do ser do mundo.
O papel da interconsulta psicológica no contexto de nefrologia: uma revisão de literatura
Authors: Mattos Isadora Juliana Pires de , Maia Amanda Sacramento , Santos Lucas Nascimento dos , Maia Yaná dos Santos , Alcântara Gislane da Conceição Gomes , Sousa Roseclévia Rodrigues , Silva Sara Nataly Cabral , Machado Gabriela Fernanda
Published: December 2024

A doença renal crônica gera significativas repercussões à saúde física e mental do paciente, além de perdas em diversas dimensões. Visa-se, com este estudo, suscitar reflexões sobre o potencial da interconsulta psicológica frente ao paciente nefrológico. Trata-se de uma revisão de literatura integrativa, em que foram utilizadas como bases de dados Lilacs e Medline, resultando em 17 artigos selecionados para compor a pesquisa. Dessa forma, notou-se que encaminhamentos tardios à nefrologia podem resultar em desfechos clínicos não favoráveis, assim como maiores solicitações de interconsultas psicológicas. Também, percebeu-se que a atuação interdisciplinar é essencial para um atendimento integral e eficaz ao paciente, ainda que existam entraves que dificultem sua aplicação. Para mais, salientou-se sobre a importância da interconsulta psicológica no contexto da nefrologia, considerando a diversidade de intervenções que podem ser realizadas através deste serviço. Por fim, notou-se uma escassez de materiais nacionais sobre o assunto, assim como poucos estudos escritos por profissionais da Psicologia.
Real-time cooperative voltage regulation strategy of distribution network based on approximate dynamic programming
Authors: Gu Jingjing , Guo Mingyu , Li Ruijie , Xu Jihe , Ye Yanyi , Hu Zhizhong , Cui Shichang
Published: December 2024

Large-scale distributed renewable energy in the distribution network can result in reliability issues such as exceeding voltage limits and overloading power lines. Additionally, the rapid growth of electric vehicles has caused a surge in power demand in the distribution network. Therefore, how to guarantee the real-time stability of distribution network voltage under uncertain environment using available resources is an urgent problem to be solved. To this end, this paper proposes a cooperative voltage regulation of an on-load voltage regulator and electric vehicles for a distribution network considering multiple uncertainties. Firstly, an optimization model of the electric vehicle clusters considering the charging location and power is established, and the traditional on-load voltage regulator of distribution networks is also considered along with network operational constraints. Subsequently, a real-time cooperative voltage regulation strategy based on approximate dynamic programming is proposed, which employs segmented linear functions to process the value function to reduce the distribution network voltage offset and to ensure optimization accuracy. Numerical simulation results validate the feasibility and the effectiveness of the proposed cooperative voltage regulation technology involving electric vehicles and on-load tap changer in the distribution network.
Long-term adaptation to dietary shifts of gut microbiota in gilthead seabream (Sparus aurata)
Authors: Ruiz Alberto , Alós Josep , Gisbert Enric , Furones Dolors , Viver Tomeu
Published: December 2024

In many meta-analyses and literature reviews on fish microbiota, the provenance of the animals (farmed vs. wild) is often overlooked. Given the well-established role of diet as a key factor in shaping gut microbiota, this study investigates the impact of dietary nature by comparing the microbiota of gilthead seabream (Sparus aurata) fed a commercial diet versus a wild-type diet, all reared within a recirculating aquaculture system. Over a 60-day period, we tracked changes in gut bacterial diversity, structure, and composition following a shift from a commercial feed to a diet exclusively based on pink shrimp (Parapenaeus longirostris). Gut bacterial communities were assessed using 16S rRNA gene sequencing (Illumina MiSeq platform) with primers targeting the V3-V4 hypervariable regions. Twenty days after the dietary change, microbial diversity (Shannon index) increased in fish fed the shrimp diet compared to those fed the commercial diet, while Dominance index values decreased. Additionally, inter-individual (beta-) diversity based on Bray-Curtis distances also differed between dietary treatments. These results support further that microbiota comparisons between farmed/captive and wild fish are challenging due to the unpredictable feeding regimes and dietary variations in wild fish. However, the diet impact on microbiota diminished over time, with the differences in intra- and inter-individual diversity being reduced after 40 days, which suggests an adaptation of microbial communities to dietary changes. At this point, gut microbial communities also showed a similar taxonomical composition. Moreover, a core microbiota consisting of species belonging to the genera Ralstonia, Paraburkholderia, Fulvimonas, Pseudomonas, and Cutibacterium was maintained in all sampling times under both dietary treatments. Overall, this study serves as a conceptual approach that shows a long-term adaptation of the gut microbiota after a radical dietary change, probably driven by host-inherent factors. Furthermore, these results may be a valuable insight for feed manufacturers aiming to develop sustainable and cost-effective ingredients since they suggest that some alternative feeds and ingredients do not have adverse long-term effects on fish gut microbiota.
Quantitative study on hepatic genotoxicity of neodymium and its molecular mechanisms based on Benchmark Dose method
Authors: Wang Ning
Published: December 2024

Introduction

Neodymium, a rare earth element, has been shown to induce genotoxicity in mice, but the molecular mechanisms behind this effect are not fully understood. This study aims to investigate the genotoxic effects of intragastric administration of neodymium nitrate (Nd(NO3)3) over 28 consecutive days and to elucidate the underlying molecular mechanisms.

Methods

We detected the content of neodymium in mouse liver tissue using ICP-MS and assessed the percentage of tail DNA in mouse hepatocytes using the alkaline comet assay to evaluate genotoxicity. Additionally, we evaluated genetic toxicological biomarkers (reactive oxygen species (ROS), 8-hydroxy-2′-deoxyguanosine (8-OHdG), and γ-H2AX) and the expression levels of genes related to the p53 pathway in the mouse liver.

Results

Our findings indicate a potential accumulation of (Nd(NO3)3) in the livers of mice, leading to DNA double-strand breaks in hepatocytes, as evidenced by comet and γ-H2AX assays. Nd(NO3)3 significantly increased the percentage of tail DNA in hepatocytes and upregulated the expression of molecules related to the p53 pathway, including ATM, Wip1, ATR, Chk2, MDM2, p53, p21, and NF-κB, at the transcriptional level. The treatment also effectively triggered the production of ROS, 8-OHdG, and γ-H2AX in liver tissue.

Discussion

These results suggest that (Nd(NO3)3) induces hepatic genotoxicity and injury in mice and modulates the expression of genes associated with DNA damage response, carcinogenesis, and inflammatory processes. The study provides insights into the molecular mechanisms by which neodymium nitrate exerts its genotoxic effects and underscores the importance of further investigating the potential health risks associated with neodymium exposure.
Identification of a novel mutation in the OsMRP5 gene in low phytate Basmati rice mutant and development of CAPS marker for marker-assisted breeding
Authors: Qamar Zia-ul- , Uzair Muhammad , Hameed Amjad , Zafar Syed Adeel , Li Xueyong
Published: December 2024

Low phytate level is a desirable trait because it promotes mineral bioavailability and thus offers a solution to tackle mineral deficiencies. The objectives of the present study were to characterize low phytate (lpa) Basmati rice mutants for the identification of novel mutations in target gene(s) and to develop a PCR-based CAPS (cleaved amplified polymorphic sequence) marker for low phytate Basmati rice. For this purpose, cultivar Super Basmati (Q4) was irradiated with gamma rays (60Co source) and three mutants named Q1 (lpa-5-9), Q2 (lpa-9-13), and Q3 (lpa-59-14) were isolated. Four genes previously been reported for the low phytic acid trait in rice were sequenced in these mutants and no mutation was observed in Q1 and Q2. However, in Q3 (lpa14) mutant a novel mutation in OsMRP5 gene (LOC_Os03g04920`) was detected. Sequence analysis displayed a substitution in the first exon of OsMRP5 at position 1142 bp resulting in the amino acid change from glycine (Gly) to alanine (Ala) at position 381a.a. To facilitate low-phytate breeding program, CAPS marker was developed to confirm this mutation site using the restriction digestion by AluI restriction enzyme. After enzyme digestion, Q3 produces four bands (32, 220, 154, and 32 bp) while Q4 (parent cultivar Super Basmati) produces only 3 bands (32, 374, and 32 bp). These results showed that this CAPS marker is 100% linked with this mutation and can be used for future breeding programs. Present findings provided insights in molecular basis of low phytate trait in rice paving the way for developing low-phytate rice varieties through marker-assisted breeding.
Transcriptomics and metabolomics analyses reveal pollen abortion mechanism in alfalfa early stage male sterile lines
Authors: Cai Huicai , Zhang Shuhe , Yu Weijie , Jia Xue , Yu Lan , Xu Bo , Wang Yingzhe
Published: December 2024

Alfalfa (Medicago sativa L.), a prominent perennial forage in the legume family, is widely cultivated across Europe and America. Given its substantial economic value for livestock, breeding efforts have focused on developing high-yield and high-quality varieties since the discovery of CMS lines. However, progress is restricted by the limitations of existing CMS lines, necessitating the development of new lines and study of the molecular mechanisms underlying pollen abortion. This study investigates early-stage anther development in cytoplasmic male sterile (CMS) alfalfa lines (MSJN1A) in relation to the isotypic maintainer line (MSJN1B). Histological analyses revealed abnormal degradation of tapetal cells post-meiosis in the CMS line. Notably, during the early mononuclear stage, the central vacuoles in the microspores were absent, leading to evident pollen abortion. These findings suggest that pollen abortion in the CMS line is associated with the delayed disintegration of the tapetum and structural anomalies in microspore vacuoles. Non-targeted metabolome sequencing revealed 401 and 405 metabolites at late tetrad and early mononuclear stages of alfalfa, respectively. Among these, 39 metabolites were consistently upregulated, whereas 85 metabolites were downregulated. Differential analysis revealed 45 and 37 unique metabolites at each respective stage. These metabolites were primarily featured in pathways related to energy, phenylpropane, sucrose and starch, and fatty acid metabolism. Integrated analysis demonstrated that differentially expressed genes and differential metabolites were co-enriched in these pathways. Additionally, quantitative real-time PCR and physiological index analysis confirmed downregulation of key genes involved in anther development, illustrating that changes in upstream gene regulation could significantly impact downstream metabolite levels, ultimately influencing pollen fertility. Pollen abortion is related to abnormal phenylpropane metabolism, fatty acid metabolism and starch and sucrose pathway, which provides reference for further research on the causes of pollen abortion of alfalfa.
Phytohormones involved in vascular cambium activity in woods: current progress and future challenges
Authors: Ding Wenjing , Wang Chencan , Mei Man , Li Xiaoxu , Zhang Yuqian , Lin Hongxia , Li Yang , Ma Zhiqiang , Han Jianwei , Song Xiaoxia , Wu Minjie , Zheng Caixia , Lin Jinxing , Zhao Yuanyuan
Published: December 2024

Vascular cambium is the continuation of meristem activity at the top of plants, which promotes lateral growth of plants. The vascular cambium evolved as an adaptation for secondary growth, initially in early seed plants, and became more refined in the evolution of gymnosperms and angiosperms. In angiosperms, it is crucial for plant growth and wood formation. The vascular cambium is regulated by a complex interplay of phytohormones, which are chemical messengers that coordinate various aspects of plant growth and development. This paper synthesizes the current knowledge on the regulatory effects of primary plant hormones and peptide signals on the development of the cambium in forest trees, and it outlines the current research status and future directions in this field. Understanding these regulatory mechanisms holds significant potential for enhancing our ability to manage and cultivate forest tree species in changing environmental conditions.
Resources, support, and integration as potential barriers and facilitators to the implementation of blended therapy in the routine care of inpatients: a qualitative study
Authors: Gupta Nikita , Leuba Sophie , Seifritz Erich , Berger Thomas , Kawohl Wolfram
Published: December 2024

While research on blended therapy (BT), i.e. the combination of face-to-face and digital treatment, has grown rapidly, integrating BT into routine practice remains limited, especially in inpatient settings. This study seeks to investigate the potential barriers healthcare providers and patients are confronted with in implementing BT to inpatients. Here, a retrospective, explorative qualitative research design was employed to gain insights into the experiences of healthcare professionals and inpatients in a real-world clinical setting. Specifically, we utilized semi-structured interviews to explore three key aspects: time resources, organizational support, and integration. A total of 11 therapists and 6 patients were interviewed. To our knowledge, this is one of the first studies to examine the implementation of blended therapy in the routine care of inpatients. We found that therapists emphasized several barriers including overwhelming workloads with insufficient time allocated for the work with the digital tools, inadequate time adjustments, a lack of ongoing training, and the necessity for a well-defined concept and setting of how to implement blended therapy. Interestingly, fewer barriers were reported by patients, who viewed the e-mental health platform as a valuable addition to their standard therapy. They also judged guidance and integration by their therapists as satisfactory and appreciated the adaptability offered in managing their workload in a flexible setting.
Zur Entwicklung und Verwendung des Terminus Nominalphrase
Authors: Feret Magdalena Zofia
Published: December 2024

The paper presents the development and use of the term noun phrase in modern German studies. First, the origin and development of the term and concept are presented. Subsequently, the author discusses the results of a survey carried out among students and teaching staff of Polish German studies, as well as a study including the available Internet sources. The aim was to check to what extent the terminology pertaining to the nominal phrase, which is largely borrowed from the English-language linguistics, is known and used. Unfortunately, the analysis showed a relatively low degree of knowledge and the use of some terms in Polish studies of the German language.
Termin substytucja w ujęciu fonodydaktycznym i logopedycznym. Analiza porównawcza
Authors: Biernacka Michalina
Published: December 2024

The article examines the term substitution by focusing on the ways in which it has been defined and/or applied in the context of pronunciation errors, especially by two different scientific disciplines: Polish language teaching (more precisely: phonodidactics) and speech therapy. Interestingly, despite the fact that the term refers to the same or similar object of study, it is not necessarily used with the same meaning. The paper opens with a review of definitions from general and specialized dictionaries along with a formulation of the concept. The study was carried out according to a socio-terminology approach, taking into account the contextual updating of meanings, observed polysemy and synonymy, as well as a socio-cognitive approach, checking the popularity of using the term and ways of understanding it in a specific context. Both the general term and the term specified by a modifier (e.g., phonetic, phonological substitution) have been described and exemplified thanks to the database of texts from both disciplines to show similarities and differences resulting from the adopted perspectives or goals (research or practical ones) that the representatives of each fi eld of study set for themselves. The analysis made it possible to observe the process of determinologization, as well as the co-occurrence of several different concepts in both disciplines, referenced by the same terms. The study fi ts into the descriptivist trend, but it aspires to be a point in the discussion about the precise formulation of descriptions, especially in disciplines that share interests with other fitelds of science.
Research on Temperature Field Analysis Method of High-Speed Bearing Chamber–Bearing System
Authors: Gong Ping , Zhang Jingjing , Liu Zhenxia , Li Manyuan
Published: December 2024

The analysis of the temperature field of a high-speed bearing chamber–bearing system is very complex. We used the temperature field analysis method on a 40,000 rpm bearing chamber–bearing system by simulation, which builds on the finite volume method and introduces a decoupling method that separates fluid dynamics from the thermal analysis of the solid temperature field. Firstly, according to bearing operating conditions, the characteristics of the oil–air two-phase distribution in the bearing chamber are determined using the Volume of Fluid (VOF) method. The convective heat transfer boundary conditions derived from this analysis serve as the thermal boundary conditions for the subsequent thermal analysis. Secondly, considering the heat generation of the bearings and the thermal boundary conditions, a temperature field analysis model is formulated. The calculated results are found to be in close agreement with the actual test data, with an error of less than 10% under three operational conditions. Thirdly, the presented method to evaluate the temperature field of the bearing chamber–bearing system has not been studied in other published literature. Additionally, compared with the thermal fluid–structure interaction method, the method described in this paper can save 90.75% of calculation time, which significantly improves efficiency. Therefore, the above method is reliable for evaluating the temperature field of the bearing chamber–bearing system.
Review on Advanced Model Predictive Control Technologies for High-Power Converters and Industrial Drives
Authors: Yu Zeyi , Long Jiang
Published: December 2024

Model predictive control (MPC) has emerged as a very popular control technology. This paper presents and discusses the major applications and recent research advances of MPC in the field of high-power converters and industrial drives. The classic concepts and implementation principles of MPC for power electronic control are reviewed, followed by the classification and application schemes of MPC in electrical drive systems. This paper discusses typical MPC techniques. Based on the results of extensive discussions on the latest research, this paper analyzes some key application issues of MPC in industrial control solutions, including the optimization and elimination of weighting factors, improvement of steady-state performance, and robustness improvement. It also covers research trends in advanced MPC. By reviewing advanced MPC solutions, this paper contributes to enhancing the performance in applications of high-power converters and industrial drives, and providing multiple perspectives to improve control performance of MPC. The presented content aims to provide readers with a precise overview and facilitate their future research in this attractive area.
Dissecting Interactions of Saccharomyces cerevisiae and Pichia kudriavzevii to Shape Kiwifruit Wine Flavor
Authors: Wang Yi-Wen , Huang Yi-Fen , Guo Ya-Qi , Sun Li , Jiang Zhi-Lin , Zhu Yuan-Ting , Zeng Rui-Qi , Li Qi , Xiao Chen , Zuo Yong
Published: December 2024

Mixed fermentation with Saccharomyces cerevisiae and Pichia kudriavzevii has been shown to enhance wine aroma, yet the underlying mechanisms remain unclear. Monoculture of S. cerevisiae, monoculture of P. kudriavzevii, and mixed culture of S. cerevisiae and P. kudriavzevii were conducted, and the study analyzed and compared the biomass, flavor profile, and transcriptome responses of the three groups. Both yeast species exhibited growth inhibition in mixed culture, especially P. kudriavzevii. Significant differences were observed in three organic acids and the foremost 20 volatile compounds. Mixed fermentation enhanced esters (e.g., ethyl butyrate, isoamyl acetate) and volatile acids (e.g., hexanoic acid), but decreased isobutanol, phenylethyl alcohol, and quinic acid. Transcriptomic analysis revealed 294 and 332 differentially expressed genes (DEGs) in S. cerevisiae and P. kudriavzevii, respectively. The Kyoto Encyclopedia of Genes and Genomes (KEGG) annotation results indicated that DEGs in mixed fermentation were concentrated in carbohydrate metabolism and amino acid metabolism. Our integrated analysis suggested that genes such as TDH2, TDH3, and ENO2 were pivotal for ester biosynthesis. Moreover, ADH1, ADH2, HPA3, ALD6, and ARO8 were associated with quinic acid synthesis. Furthermore, ILV2, ILV5, ALD6, and others were central to the production of isobutanol and phenylethyl alcohol.
Advancements in Laparoscopic Techniques for Perineal Hernias—Technical Success and Complications Data
Authors: Kalmbach Sarah , Welskopf Hannah Laura , Steidle Christoph , Horvath Philipp , Bachmann Robert
Published: December 2024

Purpose: Multimodal approaches, including radiochemotherapy and surgical resection, are commonly used to treat rectal malignancies. Postoperative perineal hernias, though not uncommon, have shown an increasing incidence in recent years. Managing symptomatic perineal hernias presents a challenge, with a high recurrence rate after repair. This retrospective study investigates the laparoscopic placement of a non-absorbable mesh for treating pelvic floor hernias involving bowel displacement. Methods: This study included all consecutive patients requiring hernia repair due to symptomatic perineal hernias following minimally invasive abdominoperineal resection. All patients had a history of local radiation therapy. Data were collected on surgery duration, intra- and postoperative complications, and hernia recurrence rates. Results: Laparoscopic displacement of the small bowel from the pelvis was performed on eight patients, and closure of the pelvic floor hernia area was achieved using non-absorbable mesh placement. All procedures were successful, and no perioperative complications were recorded. Only one early complication occurred, classified as Clavien-Dindo II. Conclusions: The laparoscopic procedure, serving as a safe method for repositioning the small intestine and closing a perineal hernia using a mesh, has shown promising outcomes. The use of a non-absorbable mesh as an alternative to native tissue appears to be effective, with no observed recurrent hernias. However, further evaluation through long-term results or a larger cohort study is still pending.
Pancreaticobiliary Reflux with Normal and Relatively Long Common Channels Causing Cholelithiasis and Acute Pancreatitis in Children
Authors: Kouchi Katsunori , Takenouchi Ayako , Matsuoka Aki , Yoshizawa Hiroko , Nakata Chikako
Published: December 2024

Background and Aims: Pancreaticobiliary maljunction (PBMJ) has a long common channel (CC) that causes pancreaticobiliary reflux (PBR), which has been implicated in gallstones, cholangiocarcinoma, and pancreatitis. By contrast, PBR has occurred in cases with normal and longer CCs than normal but shorter than PBMJ. This pathophysiology has been primarily reported in adults and rarely in children. We sometimes observe this pathophysiology in children with pancreatitis and cholelithiasis. Herein, we report the clinical figures on the diagnosis of children with PBR in normal and relatively long CCs. Patients and Methods: This study included seven children who complained of refractory pancreatitis and cholelithiasis diagnosed with PBR in normal and relatively long CCs at our institution from August 2018 to September 2024. We measured the lengths of their CCs and sphincter of Oddi muscles via endoscopic retrograde cholangiopancreatography (ERCP) and cholangiography. In addition, amylase and lipase levels in bile juice were measured. Results: All seven children demonstrated elevated amylase and lipase levels in bile juice obtained from gallbladder drainage and/or the common bile duct. ERCP and cholangiography indicated 2.2–5.5-mm lengths of CCs in their cases, which are normal lengths in two cases and relatively longer (0.3–1.1 mm: mean 0.6 mm) than the normal upper limit of CC in children in five cases, with their CCs shorter than the sphincters of Oddi. All children underwent extrahepatic bile duct resection and bilio–jejunal anastomosis, demonstrating no clinical symptom recurrence postoperatively. Conclusions: Some children with cholelithiasis and pancreatitis exhibit normal and relatively long CCs, causing PBR and inducing gastrointestinal diseases. Careful investigation by ERCP and cholangiography focused on the CC length, and pancreatic enzyme level assessments in bile juice are useful for diagnosing PBR in children with cholelithiasis and refractory pancreatitis.
A Non-Linear Approach to Current Account Sustainability—The Cases of Germany, China, and the USA
Authors: Poulakis Thanos , Kyrkilis Dimitrios
Published: December 2024

This paper examines the sustainability of the current account balances for three leading economies that play significant roles in global financial and geopolitical developments: Using the concept of sustainability as the ability of an economy to meet its long-term intertemporal budget constraint, the analysis evaluates whether the current accounts of these three economies can maintain this condition without requiring substantial policy interventions or significant changes in private sector behavior. The stationarity of the current account is considered a sufficient condition for testing the sustainability of the current account balance. However, it is argued that the common assumption of a linear process for the current account under the alternative hypothesis of stationarity may not accurately reflect reality, as the current account may exhibit non-linear behavior. Therefore, both linear and non-linear unit root tests are employed to investigate current account sustainability. The results of the unit root tests indicate that the current account balances of Germany, China, and the United States are unsustainable. These findings have significant implications for the economic stability and policy direction of these major economies.
Pipeline and Rotating Pump Condition Monitoring Based on Sound Vibration Feature-Level Fusion
Authors: Wan Yu , Lin Shaochen , Gao Yan
Published: December 2024

The rotating pump of pipelines are susceptible to damage based on extended operations in a complex environment of high temperature and high pressure, which leads to abnormal vibrations and noises. Currently, the method for detecting the conditions of pipelines and rotating pumps primarily involves identifying their abnormal sounds and vibrations. Due to complex background noise, the performance of condition monitoring is unsatisfactory. To overcome this issue, a pipeline and rotating pump condition monitoring method is proposed by extracting and fusing sound and vibration features in different ways. Firstly, a hand-crafted feature set is established from two aspects of sound and vibration. Moreover, a convolutional neural network (CNN)-derived feature set is established based on a one-dimensional CNN (1D CNN). For the hand-crafted and CNN-derived feature sets, a feature selection method is presented for significant features by ranking features according to their importance, which is calculated by ReliefF and the random forest score. Finally, pipeline and rotating pump condition monitoring is applied by fusing the significant sound and vibration features at the feature level. According to the sound and vibration signals obtained from the experimental platform, the proposed method was evaluated, showing an average accuracy of 93.27% for different conditions. The effectiveness and superiority of the proposed method are manifested through comparison and ablation experiments.