bluuebunny/crossref_metadata_2025 huggingface dataset:
A Greater Intrinsic, but Not External, Motivation Toward Physical Activity Is Associated With a Lower Sitting Time
Authors: Esmaeilzadeh Samad , Rodriquez-Negro Josune , Pesola Arto J.
Published: May 2022

Background

Both reducing sitting and increasing physical exercise promote health but exercising more does not necessarily reduce sitting time. One reason for this non-dependency may be that different aspects of exercise motivation are differently related to sitting time. Identifying the type of exercise motivation that would also be associated with sitting time can help to reduce sitting indirectly through increased exercise, thus bringing greater benefits.

Methods

The present study explored the association between quality of motivations toward physical activity with physical activity and sitting time in a total of 373 adults (age range = 23–81; women n = 256). The short version of international physical activity questionnaire (IPAQ) was used for measuring physical activity and sitting time. Reasons for exercising regularly were measured with the Self-Regulated Questionnaire–Exercise (SRQ-E), including four regulation subscales to assess regulation styles (i.e., intrinsic motivation, identified regulation, introjected regulation and external regulation). Confirmatory factor analysis (CFA) was used to test the four subscales of SRQ-E (latent variables) with the data obtained using AMOS v.23 (Analysis of Moment Structures). Then, structural equation model (SEM) with maximum likelihood estimates was used to test the hypothesized model.

Results

The results indicated that only intrinsic motivation, but not identified, introjected or external motivation, toward physical activity predicted both physical activity and sitting time. Higher intrinsic motivation toward physical activity was associated with both higher physical activity and lower sitting time. In addition, physical activity was a mediator for lower sitting time when the source was intrinsic motivation.

Conclusion

Previous studies have shown low between and within participant correlation between sitting time and physical activity, and interventions have generally failed to both increase physical activity while decreasing sitting time. The present cross-sectional results suggest that targeting increased physical activity by increased intrinsic motivation has the potential to both increase physical activity and decrease sitting time.
Internet Use, Social Networks, and Loneliness Among the Older Population in China
Authors: Tang Dan , Jin Yongai , Zhang Kun , Wang Dahua
Published: May 2022

While the rate of Internet use among the older population in China is rapidly increasing, the outcomes associated with Internet use remain largely unexplored. Currently, there are contradictory findings indicating that Internet use is sometimes positively and sometimes negatively associated with older adults’ subjective well-being. Therefore, we examined the associations between different types of Internet use, social networks, and loneliness among Chinese older adults using data from the Chinese Longitudinal Ageing Society Survey (N = 1863). Internet use was classified as interpersonal communication and information acquisition, and social networks were divided into family and friendship ties. The results showed that both interpersonal communication and information acquisition were associated with lower loneliness. Interpersonal communication can increase social networks, and family ties have a mediating effect on the association between Internet use for interpersonal communication and loneliness. Although information acquisition can directly decrease loneliness in older adults, it can also damage existing social networks and further increase loneliness. Family ties act as a suppressor in the association between Internet use for information acquisition and loneliness. Our study further discusses important implications for improving the subjective well-being of older adults in the digital era, based on the empirical findings.
The Relative Contribution of Executive Functions and Aging on Attentional Control During Road Crossing
Authors: Nicholls Victoria I. , Wiener Jan M. , Meso Andrew Isaac , Miellet Sebastien
Published: May 2022

As we age, many physical, perceptual and cognitive abilities decline, which can critically impact our day-to-day lives. However, the decline of many abilities is concurrent; thus, it is challenging to disentangle the relative contributions of different abilities in the performance deterioration in realistic tasks, such as road crossing, with age. Research into road crossing has shown that aging and a decline in executive functioning (EFs) is associated with altered information sampling and less safe crossing decisions compared to younger adults. However, in these studies declines in age and EFs were confounded. Therefore, it is impossible to disentangle whether age-related declines in EFs impact on visual sampling and road-crossing performance, or whether visual exploration, and road-crossing performance, are impacted by aging independently of a decline in EFs. In this study, we recruited older adults with maintained EFs to isolate the impacts of aging independently of a decline EFs on road crossing abilities. We recorded eye movements of younger adults and older adults while they watched videos of road traffic and were asked to decide when they could cross the road. Overall, our results show that older adults with maintained EFs sample visual information and make similar road crossing decisions to younger adults. Our findings also reveal that both environmental constraints and EF abilities interact with aging to influence how the road-crossing task is performed. Our findings suggest that older pedestrians' safety, and independence in day-to-day life, can be improved through a limitation of scene complexity and a preservation of EF abilities.
Research on Quantitative Model of Brand Recognition Based on Sentiment Analysis of Big Data
Authors: Zhou Lichun
Published: May 2022

This paper takes laptops as an example to carry out research on quantitative model of brand recognition based on sentiment analysis of big data. The basic idea is to use web crawler technology to obtain the most authentic and direct information of different laptop brands from first-line consumers from public spaces such as buyer reviews of major e-commerce platforms, including review time, text reviews, satisfaction ratings and relevant user information, etc., and then analyzes consumers’ sentimental tendencies and recognition status of the product brands. This study extracted a total of 437,815 user reviews of laptops from e-commerce platforms from January 1, 2019 to December 31, 2021, and performed data preprocessing on the obtained review data, followed by sentiment dictionary construction, attribute expansion, text quantification and algorithm evaluation. This paper analyzed the information receiving and processing hierarchy of the quantitative model of brand recognition, discussed the interactive relationship between brand recognition and consumer sentiment, discussed the brand recognition bias, style and demand in the context of big data, and performed the sentiment statistics and dimension analysis in the quantitative model of brand recognition. The study results show that the quantitative model of brand recognition based on sentiment analysis of big data can transform and map the keywords in text to word vectors in the high-dimensional semantic space by performing unsupervised machine learning on the text based on artificial neural network computer bionic metaphors; the model can accumulate each brand-related buyer review in the corresponding brand recognition dimension, so as to obtain the value of each product in each dimension of brand recognition; finally, the model will add the values of each dimension of brand recognition, that is, obtain the relevant value of the sum of each brand recognition. The results of this paper may provide a reference for further research on the quantitative model of brand recognition based on sentiment analysis of big data.
Comparison of Patterns of Non-suicidal Self-Injury and Emotion Dysregulation Across Mood Disorder Subtypes
Authors: Yang So Yung , Lee Dongbin , Jeong Hyewon , Cho Yunji , Ahn Jae Eun , Hong Kyung Sue , Baek Ji Hyun
Published: May 2022

Introduction

Non-suicidal self-injury (NSSI) is frequently encountered in patients with mood disorders. Emotion dysregulation (ED), frequently observed in mood disorders, could be a major mediating factor in NSSI. The aim of this study was to explore differences in NSSI behavior and ED across mood disorder subtypes. The relationships between childhood trauma and NSSI and ED were also explored.

Methods

A total of 191 patients with mood disorders were included in this study. The patterns of NSSI behavior and ED across patients with bipolar I disorder (BD-I), bipolar II disorder (BD-II), and major depressive disorder (MDD) were compared.

Results

More than half (54%) of the subjects experienced NSSI. Patients with BD-II and MDD engaged in NSSI behavior more frequently than those diagnosed with BD-I. NSSI behaviors in patients with BD-II most commonly included cutting, whereas hitting behaviors were most common among other groups. Patients with BD-II and MDD reported more severe ED than those with BD-I. In the case of childhood trauma, those with BD-II and MDD reported greater emotional neglect than those with BD-I. Structural equation modeling revealed that ED mediated the association between childhood trauma and NSSI.

Conclusion

BD-I was associated with less frequent NSSI behavior and less severe ED than BD-II and MDD. ED mediated the association between childhood trauma and NSSI. Promoting emotion regulation strategies could prevent NSSI behavior in patients with mood disorders.
Splitting Things Apart to Put Them Back Together Again: A Targeted Review and Analysis of Psychological Therapy RCTs Addressing Recovery From Negative Symptoms
Authors: McLeod Hamish J.
Published: May 2022

Negative symptoms have attracted growing attention as a psychological treatment target and the past 10 years has seen an expansion of mechanistic studies and clinical trials aimed at improving treatment options for this frequently neglected sub-group of people diagnosed with schizophrenia. The recent publication of several randomized controlled trials of psychological treatments that pre-specified negative symptoms as a primary outcome warrants a carefully targeted review and analysis, not least because these treatments have generally returned disappointing therapeutic benefits. This mini-review dissects these trials and offers an account of why we continue to have significant gaps in our understanding of how to support recovery in people troubled by persistent negative symptoms. Possible explanations for mixed trial results include a failure to separate the negative symptom phenotype into the clinically relevant sub-types that will respond to mechanistically targeted treatments. For example, the distinction between experiential and expressive deficits as separate components of the wider negative symptom construct points to potentially different treatment needs and techniques. The 10 negative symptom-focused RCTs chosen for analysis in this mini-review present over 16 different categories of treatment techniques spanning a range of cognitive, emotional, behavioral, interpersonal, and metacognitive domains of functioning. The argument is made that treatment development will advance more rapidly with the use of more precisely targeted psychological treatments that match interventions to a focused range of negative symptom maintenance processes.
Dropout Rates in Psychosocial Interventions for People With Both Severe Mental Illness and Substance Misuse: A Systematic Review and Meta-Analysis
Authors: Bouchard Marianne , Lecomte Tania , Cloutier Briana , Herrera-Roberge Jessica , Potvin Stéphane
Published: May 2022

Introduction

Over the years, many psychosocial interventions for individual having both a psychotic spectrum disorder and a substance use disorder diagnoses have been developed and studied. However, there is a high dropout rate among this clinical population.

Objectives

This meta-analysis aims to replicate a previous meta-analysis on the effects of psychosocial treatment for dual disorders, while including and determining the dropout rates in those type of interventions.

Method

Based on a Cochrane systematic review conducted in 2019, we conducted a meta-analysis including 40 randomized clinical trials on psychosocial treatment among persons suffering from schizophrenia spectrum disorder and substance use disorder.

Results

A dropout rate of 27,2% was obtained. Stimulants use significantly affected dropout rates. Age, gender, diagnosis, alcohol and cannabis abuse, and duration of treatment did not affect dropout rates.

Conclusion

The 27,2% rate of dropout from psychosocial treatment highlights the need to engage participants having a dual diagnosis from the start by focusing on therapeutic alliance and motivation for treatment.
Development and Validation of a Novel Diagnostic Model for Childhood Autism Spectrum Disorder Based on Ferroptosis-Related Genes
Authors: Wu Xiaolu , Li Ran , Hong Qin , Chi Xia
Published: May 2022

Autism spectrum disorder (ASD) is a highly genetic heterogeneous neurodevelopmental disorder, which is usually considered a heritable and heterogeneous neurodevelopmental disorder and has caused a great burden to society and families. Emerging roles of ferroptosis have been observed in neurological disorders. This study aimed to construct a diagnostic model based on ferroptosis-related genes (FRGs) to contribute to the early and precise diagnosis of childhood ASD. In the candidate FRGs, we identified 27 differentially expressed genes (DEGs) between ASD patients and typically developing (TD) controls. Four key FRGs were identified using the random forest analysis for further analysis. Utilization of the four gene expression, we constructed a diagnostic model and the AUC value in the training dataset (GSE18123) is 0.7002. We deem that a patient with a score less than 0.9904 is likely to have ASD. Three validation datasets (GSE111176, GSE113834, and GSE28521) were collected and the AUC value is 0.7442, 0.7444, and 0.6474, respectively. A multi-factor regulatory network based on four FRGs indicated that RORA, EAF1, NFYB, miR-4703-3p, and miR-6073 may play a role in the development of ASD. In addition, we found piperaquine may have the potential to be a promising drug for the treatment of ASD. Overall, we constructed a diagnostic model of childhood ASD, which could contribute to the precision diagnosis and timely treatment of childhood ASD.
Mental Health, Burnout, and Job Stressors Among Healthcare Workers During the COVID-19 Pandemic in Iran: A Cross-Sectional Survey
Authors: Hajebi Ahmad , Abbasinejad Maryam , Zafar Masoud , Hajebi Amirali , Taremian Farhad
Published: May 2022

Introduction

The COVID-19 pandemic has caused increasing levels of mental health problems such as anxiety and depression among doctors, nurses and other healthcare workers in hospitals or health centers. The main objective of this study was to assess the mental health, job stressors, and burnout among healthcare workers in Iran.

Materials and Methods

A cross-sectional study was performed in the primary healthcare centers and hospitals affiliated with six of the medical universities in Iran. The selection of participants was done using multi-center convenient sampling. The Patient Health Questionnaire-9, Generalized Anxiety Disorder-7, and Copenhagen Burnout Inventory were used for gathering data through an online platform. Data related to job stressors were obtained using a validated checklist. Data analysis was performed using Chi-square and multiple regression tests and the phi coefficient.

Results

The results of our study showed that 53% of the healthcare workers of the hospitals and primary healthcare centers enrolled in our study either had generalized anxiety disorder or major depressive disorder or both disorders. Moderate and high levels of burnout were seen among 48.9% of the study participants. The prevalence of mental disorders and burnout were significantly higher among the female healthcare workers compared to the male (p = 0.0001) and a higher rate of mental disorder and burnout was also seen among healthcare workers of hospitals compared to those working in primary healthcare centers (p = 0.024). “Worry about children and old members of family,” “family worries for my health condition” and “lack of specific effective treatment for COVID-19” were found to be predictive of mental disorder and burnout. The most prevalent job stressor among the total sample was “low payment or income during the COVID-19 period”.

Conclusion

The results of our study revealed high psychological distress and burnout among healthcare workers of the hospitals during the fourth peak of the COVID-19 pandemic in Iran. This study highlights the need for health officials to pay attention to the job stressors of healthcare workers and obliges them to perform effective interventions to address their needs and concerns.
Catatonia Spectrum: Validation of a Questionnaire Investigating Catatonia Spectrum
Authors: Dell’Osso Liliana , Amatori Giulia , Cappelli Andrea , Cremone Ivan Mirko , Massimetti Gabriele , Gravina Davide , Nardi Benedetta , Benedetti Francesca , Chiarantini Ilaria , Luciano Mario , Berardelli Isabella , Brondino Natascia , De Gregorio Marianna , Deste Giacomo , Nola Marta , Reitano Antonino , Muscatello Maria Rosaria Anna , Pompili Maurizio , Politi Pierluigi , Vita Antonio , Carmassi Claudia , Maj Mario
Published: May 2022

Aim

A growing body of literature has demonstrated the utility of a dimensional perspective on mental disorders. The current study aims to determine the psychometric properties of the Catatonia Spectrum (CS), a new questionnaire specifically tailored to assess the spectrum of catatonia, from full blown forms to subthreshold ones.

Methods

86 adults with at least three symptom criteria for catatonia according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), 81 adults affected by borderline personality disorder (BPD), 104 adults with a diagnosis of major depressive disorder (MDD), and 105 subjects without mental disorders (CTL), were recruited from six Italian University Departments of Psychiatry and administered the: Bush-Francis Catatonia Rating Scale (BFCRS), Bush-Francis Catatonia Screening Instrument (BFCSI), and CS.

Results

CS scale demonstrated a high level of internal consistency and excellent test-retest reliability for total and domain scores. CS domain scores were positively and significantly correlated with each other (p < 0.001) with Pearson’s coefficients ranging from 0.337 to 0.663. All the CS domain scores were highly correlated with the CS total score. The correlation coefficients between CS and alternative measures of catatonia appeared all significant and positive. Significant differences among diagnostic groups on both CS domains and total scores were found. CS total scores increased significantly and progressively from the CTL, to the MDD and the BDP group, up to the catatonia group, which reported the highest value.

Conclusion

The CS showed excellent internal consistency and test-retest reliability and strong convergent validity with alternative dimensional measures of catatonia. The questionnaire performed differently across the four diagnostic groups, with an increasing score gradient from healthy controls to patients with MDD, BPD and up to the catatonia group.
Case Report: Severe Listeria Encephalitis With Complicated or Secondary Autoimmune Encephalitis and CNS Demyelinating Diseases
Authors: Zhang Xiaomin , Feng Peng , Meng Pengfei , Li Dongfang , Gao Huizhong , Zhao Yang , Yuan Jingjing , Wang Yongqing , Xia Han
Published: May 2022

Background

Listeria monocytogenes is an important food-borne bacterium. It rarely infects patients with complete immunity and causes meningocephalitis. Patients with severe Listeria encephalitis always experience a bad prognosis.

Case Presentation

A 39-year-old male patient was admitted to our hospital due to fever for more than 10 days and disturbance of consciousness accompanied by convulsions for 2 days. Metagenomic next-generation sequencing (mNGS) results showed L. monocytogenes in both cerebrospinal fluid (CSF) and blood, indicating L. monocytogenes encephalitis. Autoimmune encephalitis and central nervous system (CNS) demyelinating autoantibodies in the CSF also showed positive results. The case was finally diagnosed as severe Listeria encephalitis with complicated or secondary autoimmune encephalitis and CNS demyelinating diseases.

Conclusions

It is necessary to carry out infection and immunity screening in patients with severe encephalitis, especially for immunocompromised patients. mNGS plays a pivotal role in screening patients with severe and difficult neurological diseases.
Baropodometric Assessment of the Podiatric Profile of Nursing Students in Clinical Settings: A Study Protocol
Authors: Bernardes Rafael A. , Caldeira Sílvia , Parreira Pedro , Sousa Liliana B. , Almeida Inês F. , Santos-Costa Paulo , Paiva-Santos Filipe , Guardado Cruz Arménio
Published: May 2022

Introduction

Nursing students are exposed to increased risks of developing foot and ankle disorders due to prolonged standing and walking positions during clinical settings. This can lead to high dropout rates from nursing degree, thus contributing to a future shortage in nursing professionals. This protocol aims to develop a study to understand the influence of prolonged standing and walking positions on nursing students' foot health, and specifically to study the relationship between the podiatric profile (regional force and pressure exerted on the foot) and related signs and symptoms.

Methods and Analysis

A prospective observational cohort study will be conducted with 194 nursing students. Participants will be asked to walk through a baropodometric platform before and after a 5-month clinical training session. Assessment will focus on the change in podiatric profile, namely foot posture and foot function, at 5 months, and changes in foot health at 5 months. The study will start in January 2022 and it's expected to end by June 2022.

Discussion

The study aims to perform an innovative assessment of nursing students' podiatric profile, which will allow for a comprehensive description of foot/ankle changes and their relationship with prolonged standing and walking contexts.

Ethics and Dissemination

The study was approved by The Ethical Committee of the Health Sciences Research Unit: Nursing (UICISA: E), of the Nursing School of Coimbra (ESEnfC), with the approval code nr. P799_07_2021. The study was also recorded in ClinicalTrials.gov on the number NCT05197166. Findings will be used to publish articles in peer-review scientific journals and oral communications and posters at scientific meetings.
On Imported and Domestic Human Papillomavirus Vaccines: Cognition, Attitude, and Willingness to Pay in Chinese Medical Students
Authors: Zhou Liangru , Gu Baiyang , Xu Xiaoxue , Li Yue , Cheng Pengxin , Huo Yue , Liu Guoxiang , Zhang Xin
Published: May 2022

This study aimed to analyze the cognition, attitude, and willingness to pay (WTP) for imported and domestic human papillomavirus (HPV) vaccines in Chinese medical students.

Methods

Medical students in Eastern, Central and Western China were investigated. We used the HPV cognitive list to measure the cognition of participants and implemented contingent valuation method (CVM) to value WTP. Tobit model was used to analyze the factors associated with WTP.

Results

The participants' average score for the 21 cognitive questions was 13.05 (±5.09). Among the participants, 60.82 and 88.01% reported that they would wish to be vaccinated and support the partners to be vaccinated. In addition, 92.54% (670) of the participants were willing to pay for HPV vaccines, at mean values (in RMB) of 1,689.80 (±926.13), 2,216.61 (±1190.62), and 3,252.43 (±2064.71) for imported bivalent, quadrivalent, and 9-valent vaccines, respectively, and at 910.63 (±647.03), 1,861.69 (±1147.80), and 2,866.96 (±1784.41) for their domestic counterparts, respectively. The increase in cognitive score has a positive effect on the WTP for imported vaccines (P < 0.05).

Conclusions

Most of the participants were likewise willing to receive the HPV vaccines. Their perceptions of the HPV vaccines valent and origin may affect their willingness to be vaccinated and pay for the vaccines. Increasing awareness of the HPV vaccines and the inclusion of the HPV vaccines in a Medicare reimbursement policy or immunization program could increase the coverage of the HPV vaccine.
Social Integration as Mediator and Age as Moderator in Social Capital Affecting Mental Health of Internal Migrant Workers: A Multi-Group Structural Equation Modeling Approach
Authors: Zhou Jingjing , Zhou Jianfang , Zhang Hongyang , Zhang Junwei
Published: May 2022

The rise of migrant workers has been a unique social phenomenon as China goes through industrialization, urbanization, and modernization. They are a special social group formed during the economic and social transition of the country. Migration of rural labor has pushed China on its new path toward industrialization and urbanization. Because of the urban-rural dual system of the country, however, it is difficult for migrant workers to be fully integrated into host cities, making them susceptible to negative emotions and mental health issues. Therefore, their mental health is an issue of great volume in the domains of social undertakings, people's livelihood, and public health. However, existing studies have paid limited attention to the psychological profile of migrant workers and even less to the interplays among their social capital, social integration, and mental health. Targeting China's internal migrant workers, this article tapped the interactions among their social integration, social capital, and mental health with a sample of the cross-sectional data from the China Labor Dynamics Survey (CLDS) in 2018. Multi-group structural equation modeling (SEM) was employed to test the moderating action of age by analyzing whether the mediation model differed significantly in the paths among young, middle-aged, and older migrant workers. The SEM based on bootstrapping suggested that, after controlling for the influence of gender, education, marital status, personal annual income, employer type, and self-rated health, migrant workers' social capital positively affect their mental health in a significant way, with social integration playing a mediating role. In terms of age difference, middle-aged migrant workers were more subject to the aforementioned mechanism than young ones, and young migrant workers were more affected by the mechanism than older ones. This study revealed different psycho-social interplays among social capital, social integration, and mental health across young, middle-aged, and elderly migrant workers. The findings could serve as an important theoretical reference and as practical guidance for improving policies concerning migrant workers' mental health and social benefits in the context of economic transition.
Side Effects of COVID-19 Inactivated Virus vs. Adenoviral Vector Vaccines: Experience of Algerian Healthcare Workers
Authors: Lounis Mohamed , Rais Mohammed Amir , Bencherit Djihad , Aouissi Hani Amir , Oudjedi Adda , Klugarová Jitka , Pokorná Andrea , Klugar Miloslav , Riad Abanoub
Published: May 2022

Healthcare workers were prioritized in vaccination campaigns globally because they are exposed to the highest risk of contamination by SARS-CoV-2. This study evaluated the self-reported post-vaccination side effects of inactivated (BBIBP-CorV and CoronaVac) and adenoviral vector-based (AZD1222, Gam-COVID-Vac and Ad26.COV2.S) vaccines among Algerian healthcare workers using a validated questionnaire. The final analysis included 721 healthcare workers, with a predominance of females (59.1%) and younger individuals 20–30 years old (39.4%). Less than half (49.1%) of the respondents reported at least one local side effect, while 53.8% reported at least one systemic side effect. These side effects were more prevalent among viral vector vaccinees than inactivated virus vaccinees. The most common local side effects were injection site pain (39%) and arm pain (25.4%), while fatigue (34.4%), fever (28.4%), headache (24.8%) and myalgia (22.7%) were the most prevalent systemic side effects. The side effects appeared earlier among inactivated virus vaccines recipients and generally lasted for 2 to 3 days for the two vaccinated groups. The risk factors associated with a higher prevalence of side effects included female gender, allergic individuals, individuals with regular medication, those who contracted the COVID-19 disease and those who received two doses for both inactivated and viral-based vaccines groups. Despite the higher prevalence of post-vaccination side effects among adenoviral vector vaccines recipients, both vaccines groups were equally effective in preventing symptomatic infections, and no life-threatening side effects were reported in either vaccine group.
Revisiting Urban Resilience: A Review on Resilience of Spatial Structure in Urban Refugee Neighborhoods Facing Demographic Changes
Authors: Alawneh Salwa M. , Rashid Mahbub
Published: May 2022

Providing a durable and sustainable approach based on urban resilience is essential for solving many spatial challenges in neighborhoods with sudden refugee influxes. As refugees settle in different locations in host cities, many of these neighborhoods have high urbanization, poor infrastructure, and over-population and their conditions impact their urban stability, livability, and quality of life. Hence, this study will review the urban resilience literature focusing on a set of resilient spatial elements of a neighborhood to support the design and planning of refugee settings. First, the theories of urban resilience are reviewed to identify the characteristics of resilience and classify the reviewed literature by different focused categories of spatial resilience. Second, the resiliency of spatial structure are explored focusing on the links between resilient characteristics and urban form attributes at the neighborhood scale. The review summarizes a set of resilient spatial measurements that use urban form indicators of resilient characteristics facilitated by geospatial technologies. Further, a framework of resilient spatial structure for refugee neighborhoods is proposed using existing urban resilience frameworks. The proposed framework includes factors of urban form attributes at the neighborhood scales (e.g., blocks, plots, and building scale), resilience in refugee contexts, and urban resilience mechanisms. The study is not limited to providing an operative resilience knowledge. It provides spatial strategies for humanitarian organizations and inter-governmental agencies to improve the vulnerable spatial structures of refugee settings and to broaden opportunities for the assessment, profiling, communication, monitoring, and planning of resilient refugee neighborhoods.
From Coronal Holes to Pulsars and Back Again: Learning the Importance of Data
Authors: Wang Y.-M.
Published: May 2022

Although wanting to become an astronomer from an early age, I ended up in solar physics purely by chance, after first working in high-energy astrophysics. I’ve never regretted switching from the pulsar to the solar magnetosphere, because solar physics has a great advantage over other areas of astrophysics—in the enormous amount of high-quality data available, much of it underutilized. I’ve often wondered why theoreticians and modelers don’t spent more time looking at these data (perhaps they feel that it is cheating, like taking a peek at the answers to a difficult homework assignment?). Conversely, I wonder why observers and data analysts aren’t more skeptical of the theoretical models—especially the fashionable ones.
Correlation of NO and ET-1 Levels with Blood Pressure Changes in Hemodialysis Patients after Arteriovenous Fistula Surgery
Authors: Li Yanli , Lu Hanxiao , Sun Yu
Published: May 2022

Hemodialysis (HD) is the most common renal replacement therapy for patients with end-stage renal disease (ESRD) and can significantly reduce mortality and improve the quality of life of patients. The occurrence of intradialytic hypotension and intradialytic hypertension are important risk factors for death and disability during dialysis in patients with ESRD, yet their etiology remains unclear, and some studies suggest that nitric oxide (NO) and endothelin-1 (ET-1) may play an important role in these hemodynamic alterations. For this purpose we examined the changes in NO and ET-1 levels during hemodialysis in 30 patients on maintenance hemodialysis (MHD) after arteriovenous fistula surgery. Thirty dialysis patients were divided into group I (stable blood pressure during dialysis), group II (Intradialytic hypotension) and group III (Intradialytic hypertension) according to the change of blood pressure (BP) during hemodialysis, with 10 cases in each group. BP of MHD patients were measured Pre-dialysis (Pre-D), at 1 h of dialysis (1h-D), at 2 h of dialysis (Mid-D, 2h-D), at 3 h of dialysis (3h-D), and at the end of dialysis (Post-D); and blood samples were taken from the arterial end at Pre-D, Mid-D, and Post-D to measure NO and ET-1 levels. The results of the analysis showed that as dialysis proceeded and ended, the NO levels in the three groups gradually decreased, with significant differences compared with those before dialysis (p < 0.05); the ET-1 levels in group III gradually increased, with significant differences compared with those before dialysis (p < 0.05), while the increasing trend of ET-1 levels in group I and group II was not significant. The increasing trend of MAP in group I was not significant (p > 0.05); MAP in group II showed a gradual decrease and MAP in group III showed an increasing trend, and the difference between MAP after dialysis and before dialysis was significant (p < 0.05). Correlation analysis showed a significant positive correlation between ET-1 levels and MAP in Group III at Mid-D (r = 0.847, p = 0.002). This shows that serum ET-1 and NO levels are significantly higher than normal in MHD patients after arteriovenous endovascular fistula surgery, and both ET-1 and NO levels are changing during dialysis, and there may be a link between their changes and blood pressure changes. It is suggested that the blood pressure fluctuations that occur during dialysis in MHD patients may be related to endothelial cell dysfunction.
Correlation Among Self-Care Ability, Psychological Status, and Quality of Life in Discharged Patients with Hepatolithiasis Complicated with Diabetes Mellitus and T-Tube
Authors: Huang Chunqiu , Wang Ying , Cai Yimin , Shen Zhoumin , Zhang Honghui , Tan Zhaoxia , Chen Hongjiao , Zhou Bifang
Published: May 2022

Objectives

This study aimed to investigate the correlation between self-care ability, psychological status, and quality of life in patients with hepatolithiasis complicated with diabetes mellitus with T-tube.

Methods

The purpose of this study was to select a total of 240 patients with hepatolithiasis complicated with diabetes with T-tube from June to September 2019 in a Third-class Grade A hospital in Changsha, Hunan Province. Self-designed general information questionnaire, self-care ability implementation scale (ESCA), self-rating anxiety scale (SAS), self-rating depression scale (SDS), and quality of life scale (SF-36) were used to conduct a questionnaire survey. The correlation among self-care ability, psychological status, and quality of life of patients with hepatolithiasis complicated with diabetes mellitus with T-tube was analyzed.

Results

The total score of self-care ability of 240 patients with hepatolithiasis combined with diabetes with T-tube was positively correlated with the total score of quality of life (p < 0.05). The standard scores of anxiety and depression were negatively correlated with the total score of quality of life (p < 0.05). The total score of self-care ability was negatively correlated with the standard score of anxiety and depression (p < 0.05).

Conclusion

Improving the self-care ability of patients with hepatolithiasis complicated with diabetes with T-tube and improving their anxiety and depression can improve their quality of life, which provides reference for further study.
Anal Canal Duplication Mimicking Recurrent Abscess: A Case Report and Review of the Literature
Authors: Li Dandan , Liu Shuaibin , Feng Jiexiong , Yang Jixin
Published: May 2022

Background

Anal canal duplication (ACD) is a very rare duplication of the gastrointestinal tract and is described as a secondary anal orifice along the posterior side of the normal anal canal. Early surgical removal is advisable, also in asymptomatic patients, because of the risk of inflammatory complications, such as recurrent crissum abscess, and malignant changes.

Case presentation

A previously healthy 2-year-old boy was evaluated in the emergency department with fever. He complained of anal pain in the absence of incentive. Physical examination and ultrasound confirmed a diagnosis of perianal abscess. He was treated with incision and drainage of the abscess and intravenous antibiotics. Two months after his discharge from the hospital, he developed fever and had intervals discharge pus and pain in the same locations. Colorectal endoscopy revealed that there was no fistula opening at the rectal wall. Intraoperative fistulography showed a fistulous tract that was connected to a subcutaneous cavity. Excision of the fistulous tract and wide drainage of the deep postanal space were performed. The patient was referred to our hospital for further evaluation 6 months later. Physical examination showed a secondary anus that had not been noticed before. MRI showed an anal fistula between 1 and 3 o’clock, and preoperative fistulography revealed a 3-cm-long tubular structure without any connection with the rectum. The diagnosis of ACD was made by intraoperative examination with a metal catheter and the postoperative pathological analysis. The duplicated anal canal was resected completely via a perianal approach without any rectal injury. Histology showed a squamous epithelium in the distal end with some smooth-muscle fibers. After a follow-up of 8 months, the patient has been doing well.

Conclusion

Recurrent crissum abscess should raise clinical attention to alimentary tract congenital malformations such as ACD. Prompt recognition of these unique presentations of ACD is needed, and complete excision through a perineal approach or posterior sagittal approach is recommended.
Phenotypic Characterization of Idiopathic Epilepsy in Border Collies
Authors: Santifort Koen M. , Bertijn Elise , Bhatti Sofie F. M. , Leegwater Peter , Fischer Andrea , Mandigers Paul J. J.
Published: May 2022

The prevalence of idiopathic epilepsy (IE) within the Border Collie (BC) dog breed is high. The aim of this retrospective study was to describe the phenotype of BCs with IE and assess correlations between phenotypic variables and owner-provided quality-of-life (QoL) scores. Data of BCs diagnosed with IE during the period of five consecutive years were retrospectively analyzed. All the dogs were presented at least once to a veterinary neurology specialist at one of three veterinary referral hospitals and most were under the continued medical care of that specialist. Owners were requested to complete a standardized online questionnaire including quality-of-life (QoL) scoring questions. Data of a total of 116 BC dogs were included for analysis. The median age at onset of the first epileptic seizure (ES) was 33.5 months (6–188). A total of 34/86 (40%) of medically treated dogs received 1 antiseizure medication (ASM) and 52/86 (60%) received ≥2 ASMs. Phenobarbital was the most commonly employed ASM, used in 70/86 of treated dogs (81%). Four or more side effects were observed in 20/86 (23%) of treated dogs. Age at onset of first ES was significantly lower for dogs having experienced cluster seizures (CSs), status epilepticus (SE), or both (median 27 months) vs. dogs that had not experienced CS or SE (median 43 months). The QoL of BC with IE was scored with a median score of 7 out of 10. Owners scored their dog's QoL to have declined by a median of 30% during the course of life with IE with 39% (37/95) of owners scoring their dog's QoL to have declined by ≥50%. This study confirms the association of age at onset of first ES with the severity of epilepsy (e.g., presence of CS and/or SE) and further characterizes the phenotype of IE in BC dogs. QoL of BC can be heavily impacted by IE.
Effects of Glycyrrhiza Polysaccharides on Chickens' Intestinal Health and Homeostasis
Authors: Wu Yu , Wu Chenyang , Che Yanyun , Zhang Tao , Dai Chen , Nguyễn Audrey D. , Duan Kun , Huang Yanyu , Li Nannan , Zhou Hui , Wan Xin , Wang Yuedi , Lei Hongjun , Hao Ping , Li Caiyue , Wu Yi
Published: May 2022

The overuse of antibiotics in poultry farming causes the accumulation of drug residue in animals' bodies and the occurrence of antibiotic-resistant bacteria, which not only compromise animals' health but ultimately endanger human health. Thus, there is an urgent need for a novel poultry feed additive to substitute for excessive antibiotics. Glycyrrhiza polysaccharides (GPS) derived from Chinese licorice have shown promising immunomodulatory effects in previous studies. The present study investigated the pharmacological effects of GPS on poultry intestines to assess whether it can be used as a feed additive. The results show that GPS can increase production of sIgA, promote the secretion activity of goblet cells, alter the gut microbial composition and lead to changes in short-chain fatty acids. GPS also elevated both Th1 and Th2 immune responses by facilitating the expression of IL-2, IL-4, IL-1β, and IFN-γ while increasing the proportion of both CD4+ and CD8+ cells in the intestine. Moreover, the results of 16S rRNA gene sequencing showed that GPS could significantly change intestinal microbiota composition in the intestine, evidenced by the increased proportion of Bacteroides, Butyricicoccus and Eisenbergiella, as well as a decreased portion of Erysipelatoclostridium, leading to a healthier intestinal microbiota composition for the host. Taken together, it can be concluded that GPS is safe to use as a novel feed additive that can be used as an alternative to prophylactic antibiotics in poultry feeding.
Invasive Milk Thistle (Silybum marianum (L.) Gaertn.) Causes Habitat Homogenization and Affects the Spatial Distribution of Vegetation in the Semi-Arid Regions of Northern Pakistan
Authors: Khan Nasrullah , Ullah Rafi , Ali Kishwar , Jones David Aaron , Khan Muhammad Ezaz Hasan
Published: May 2022

Global biodiversity management is of concern due to invasive plant species that dramatically disturb the native communities causing biological homogenization. Therefore, the present research investigated the impacts of Silybum marianum, an aggressive invasive alien species, on communities’ diversity and environmental variables in Khyber Pakhtunkhwa, Pakistan. Phytosociological characteristics and diversity indices of the communities were sampled in seventy-five sites using the quadrate method. These sites were categorized based on invasion intensities, i.e., fully invaded sites with a 100% importance value index of the selected species, severely invaded sites with >60% of IVI, and partially invaded sites with >30% of the chosen species. The community composition significantly changes with changes in invasion intensity. Similarly, S. marianum invasion has a pronounced impact on the community’s diversity showing significant differences among the three categorized groups (p < 0.05). The canonical correspondence analysis revealed 29.9% variance where soil texture, nutrients, and elevations were influential variables in maintaining the community’s structure and composition. The study concludes that S. marianum dominated well-established communities in the existing soil and environmental variables; therefore, it was found to be influential in disturbing the native communities and may severely harm the crop plant and agricultural system in the future.
Topping Inhibited Potassium Uptake via Regulating Potassium Flux and Channel Gene Expression in Tobacco
Authors: Liang Taibo , Dai Huaxin , Khan Waleed Amjad , Guo Yadi , Meng Xiangyu , Wang Guiyao , Zhang Yanling
Published: May 2022

Potassium (K+) is mainly absorbed by plants from the soil and is primarily transported within the plant through the xylem. Topping has been reported to cause efflux and loss of K+ in plants; however, its effect on the real-time flow rate and genotypes with varying K+ accumulation ability is still unknown. Therefore, we carried out a pot experiment containing sand culture using two tobacco cultivars EY1 (high K+ accumulating) and Y87 (low K+ accumulating). The results demonstrated the change of K+ flow direction from influx to efflux in the roots of both cultivars due to topping. The percentage ratio of K+ efflux to influx was estimated to be 18.8% in EY-1 and 157.0% in Y87, respectively. We noticed a decline in indole acetic acid (IAA) content due to topping, which activated the expression of K+ efflux channel gene NTORK1 and inhibited the expression of K+ influx channel genes NKT1 and NtKC1. Furthermore, K+ loss from the roots increased due to topping, which led to decreased K+ concentration in entire tobacco plant. Topping had a more serious impact on the K+ efflux rate and K+ loss in Y87. IAA application after topping, in turn, decreased the K+ loss in both the cultivars. We conclude that topping caused a decrease in IAA concentration and K+ losses in tobacco leaves, and these losses can be mitigated by the exogenous application of IAA.
Microbial Diversity of the Chinese Tiger Frog (Hoplobatrachus rugulosus) on Healthy versus Ulcerated Skin
Authors: Hu Hua-Li , Chen Jia-Meng , Chen Jing-Yi , Seah Rachel Wan Xin , Ding Guo-Hua
Published: May 2022

The Chinese tiger frog (Hoplobatrachus rugulosus) is extensively farmed in southern China. Due to cramped living conditions, skin diseases are prevalent among unhealthy tiger frogs which thereby affects their welfare. In this study, the differences in microbiota present on healthy versus ulcerated H. rugulosus skin were examined using 16S rRNA sequences. Proteobacteria were the dominant phylum on H. rugulosus skin, but their abundance was greater on the healthy skin than on the ulcerated skin. Rhodocyclaceae and Comamonadaceae were the most dominant families on the healthy skin, whereas Moraxellaceae was the most dominant family on the ulcerated skin. The abundance of these three families was different between the groups. Acidovorax was the most dominant genus on the healthy skin, whereas Acinetobacter was the most dominant genus on the ulcerated skin, and its abundance was greater on the ulcerated skin than on the healthy skin. Moreover, the genes related to the Kyoto Encyclopedia of Genes and Genomes pathways of levels 2–3, especially those genes that are involved in cell motility, flagellar assembly, and bacterial chemotaxis in the skin microbiota, were found to be greater on the healthy skin than on the ulcerated skin, indicating that the function of skin microbiota was affected by ulceration. Overall, the composition, abundance, and function of skin microbial communities differed between the healthy and ulcerated H. rugulosus skin. Our results may assist in developing measures to combat diseases in H. rugulosus.