bluuebunny/crossref_metadata_2025 huggingface dataset:
Genetic analyses in a cohort of Portuguese pediatric patients with congenital hypothyroidism
Authors: Santos-Silva Rita , Rosário Marta , Grangeia Ana , Costa Carla , Castro-Correia Cíntia , Alonso Isabel , Leão Miguel , Fontoura Manuel
Published: November 2019

Background

Permanent primary congenital hypothyroidism (CH) can be caused by thyroid dysgenesis or dyshormonogenesis. A molecular genetic study is recommended in dyshormonogenesis, in syndromic hypothyroidism and when there is a family history of CH. The aim of this study was to identify a monogenic etiology for CH in selected individuals from a cohort of primary permanent CH.

Methods

From an initial cohort of 79 patients with permanent CH (3–19 years), 11 patients were selected for molecular analyses. Nine patients with dyshormonogenesis (normal in-situ gland or goiter) were screened for causative variants, by next-generation sequencing (NGS), in 28 genes known to be responsible for CH. One patient with a family history of CH was screened for the paired-box gene 8 (PAX8) gene and another patient with a syndromic CH was screened for the NKX2-1 gene.

Results

We found a monogenic basis of disease in eight patients, involving the thyroid peroxidase (TPO) gene (four patients), the thyroglobulin (TG) gene (two patients), and the PAX8 and NKX2-1 genes (one patient each). Two patients were heterozygotes, one harboring a variant in the TG gene and the other in the SLC5A5 gene. In one patient, we found no potential causative variants in any of the 28 genes screened. We described five novel variants: three in the TG gene, one in the NKX2-1 and one in the SLC5A5 gene, all of them classified as pathogenic.

Conclusions

In eight of the 11 screened patients, a monogenic disease was found. These results highlight the advantage of using an NGS panel and provide further data regarding the molecular basis of CH.
Effects of vitamin D and estrogen receptor polymorphisms on bone mineral density in adolescents with anorexia nervosa
Authors: İnan-Erdoğan Işıl , Akgül Sinem , Işgın-Atıcı Kübra , Tuğrul-Yücel Tuğba , Boduroğlu Koray , Derman Orhan , Kanbur Nuray
Published: November 2019

Background

Anorexia nervosa (AN) is a serious eating disorder that is associated with decreased bone mineral density (BMD) and greater lifetime risk for fractures. The aim of this study was to determine the correlation between BMD and genetic polymorphisms in AN.

Methods

This case-control study analyzed vitamin D receptor (VDR) (VDRBsml, VDRFokl) and estrogen receptor (ESR) (ESR1Xbal, ESR1Pvull) polymorphisms in 45 adolescents diagnosed with AN and 46 age-matched healthy controls. BMD values of the AN group were classified as low or normal, and polymorphisms were compared between cases and controls. The effects of body mass index (BMI), duration of disease and amenorrhea on BMD were also evaluated.

Results

In girls with AN, a positive effect of the bb genotype of VDRBsmI polymorphism on femur Z-scores (p = 0.103) and of the Ff genotype of VDRFokI polymorphism on vertebra Z-scores (p = 0.097) was observed. In boys with AN, a positive effect of the Ff genotype of VDRFokI polymorphism on vertebra BMD (g/cm2) was detected (p = 0.061). No association was detected between ESR polymorphisms. An inverse relationship was observed between BMD and duration of illness and amenorrhea. A direct relationship was detected between BMD and BMI.

Conclusions

Specific VDR gene polymorphism genotypes may have positive effects on BMD in patients with AN. Additionally, the lack of association between ESR gene polymorphisms on BMD could be attributed to the low estrogen status of the patient.
Mental health of both child and parents plays a larger role in the health-related quality of life of obese and overweight children
Authors: Özalp Kızılay Deniz , Yalın Sapmaz Şermin , Şen Semra , Özkan Yekta , Cengiz Özyurt Beyhan , Ersoy Betül
Published: November 2019

Aims

A decrease in health-related quality of life (HRQOL) measures among obese (OB) and overweight (OW) children has been shown in several studies, but knowledge about the variables affecting HRQOL impairments is missing. The aim of this study was to evaluate the relationship between HRQOL and sociodemographic characteristics, anthropometric measurements, metabolic parameters, mental symptoms and parental attitudes in a sample of OB/OW children.

Methods

Eighty-six OB/OW children, aged between 9 and 17 years, participated in the study. We performed sociodemographic questioning, anthropometric examinations and laboratory evaluations of the participants. HRQOL was assessed using the Pediatric Quality-of-Life Inventory (PedsQL), and levels of anxiety and depressive symptoms were measured using the Screen for Child Anxiety-Related Disorders (SCARED) questionnaire and the Children’s Depression Inventory (CDI), respectively. Parental attitudes were assessed with the Parental Attitude Research Instrument (PARI) questionnaire.

Results

A statistically significant relationship was found between total scores of CDI and SCARED answered by children and the total and subscale scores of PedsQL. Scores of total quality of life subscale, physical functionality and emotional functionality subscales were significantly lower in children with a family history of mental illness. No relationship was found between PedsQL subscales, anthropometric and metabolic parameters.

Conclusions

Emotional problems and parental psychological distress are important factors in models of HRQOL in the OB/OW pediatric population.
Enhanced ink-absorption performance of inkjet printing paper-based patterns with core-shell-structure CaCO3{\mathrm{CaCO}_{3}}@SiO2{\mathrm{SiO}_{2}} pigments
Authors: Wang Huanmei , Chen Yunzhi , Zhang Zhengjian
Published: November 2019

The inorganic core-shell pigment

CaCO

3

{\mathrm{CaCO}_{3}}

@

SiO

2

{\mathrm{SiO}_{2}}

was synthesized using a sol-gel method, and the pigment was applied as a surface coating on inkjet paper to study the influence of inorganic core-shell pigments on the dynamic permeability, surface properties, optical properties and inkjet-printing performance of coated paper.

CaCO

3

{\mathrm{CaCO}_{3}}

@

SiO

2

{\mathrm{SiO}_{2}}

prepared using carboxymethyl cellulose (CMC) had better coverage than that prepared using polystyrene sodium sulfate (PSS) dispersant. The CMC-prepared

CaCO

3

{\mathrm{CaCO}_{3}}

@

SiO

2

{\mathrm{SiO}_{2}}

-a had improved dispersibility, and the solids content of the coating reached 35 %. Inorganic core-shell pigments improve the surface and optical properties of the coated paper, making them similar to those of a reference calcium carbonate-coated paper. The smoothness and gloss improved by 60.8 % and 78.4 %, respectively, compared with those of silica-coated paper. The inkjet solid density and dot definition increased by 28.8 % and 4.1 %, respectively, compared with those of the calcium carbonate-coated paper. Preparing inorganic core-shell pigment

CaCO

3

{\mathrm{CaCO}_{3}}

@

SiO

2

{\mathrm{SiO}_{2}}

is an effective method to fabricate inkjet printing coatings with advantageous microstructures for ink absorption.
Micro- structure and rheological properties of graphene oxide rubber asphalt
Authors: Lin Mei , Wang Zhao Li , Yang Ping Wen , Li Ping
Published: November 2019

Compared with traditional materials, nanomaterial has rich and excellent performance due to the size advantages. If nanotechnology is combined with pavement materials, it is foreseeable that it will have a profound impact on the development of the road. In the study, graphene oxide nanomaterial was added as modifiers to rubber asphalt and its microstructure was characterized. The rheological properties of graphene oxide rubber asphalt and the road performance of asphalt mixture were studied in accordance with the SHRP test. The results showed that graphene oxide could form a dense and stable microstructure with rubber powder and asphalt polymer. As a modifier, it could improve the anti-rutting performance of rubber modified asphalt and was more suitable for heavy traffic. Moreover, it had low sensitivity to temperature and was more suitable for areas with large temperature difference between day and night. The pavement performance of the graphene oxide rubber asphalt mixture had also been greatly improved.
First-principles calculations of mechanical and thermodynamic properties of tungsten-based alloy
Authors: Li Heng , Zhang Xin , Liu Qijun , Liu Yangyang , Liu Haifeng , Wang Xianqu , Huang Jie , Liu Hai , Xu Yuhong , Tang Changjian , Lei Guangjiu
Published: November 2019

The structural, mechanical and thermodynamic properties of tungsten-based alloys, including W0.5Ti0.5,W0.67Zr0.33,W0.666Ti0.1667Zr0.1667,W0.67Hf0.33 and W0.666Ti0.1667Hf0.1667, have been investigated in this paper by first-principles calculations based on density functional theory (DFT). The calculated elastic constants and mechanical stability criteria of cubic crystals indicated that all of these cubic alloys are mechanical stable. The mechanical properties, including bulk modulus (B), shear modulus (G), Young’s modulus(E), ratio B/G, Poisson’s ratio, Cauchy pressure and Vickers hardness are derived from the elastic constants Cij. According to calculated elastic modulus and Vickers hardness, the W0.666Ti0.1667Hf0.1667 alloy has the greatest mechanical strength. The Vickers hardness of these cubic alloys rank as follows: W0.666Ti0.1667Hf0.1667 > W0.67Zr0.33 > W0.666Ti0.1667Zr0.1667 > W0.5Ti0.5 > W0.67Hf0.33. Moreover, calculated ratio B/G, Poisson’s ratio, Cauchy pressure indicated that the ductility of W0.666Ti0.1667Hf0.1667 alloy is the worst among these alloys. The ductility of these cubic alloys rank as follows: W0.67Hf0.33 > W0.5 Ti0.5 > W0.67Zr0.33 > W0.666Ti0.1667Zr0.1667 > W0.666Ti0.1667Hf0.1667. What is noteworthy is that both mechanical strength and ductility of W0.666Ti0.1667Hf0.1667 are greater than pure W. Finally, Debye temperature, melting point and thermal conductivity have been predicted through empirical formulas. All these results will provide scientific data for the study on new product development of electrode materials.
Accounting for Variation in Language
Authors: Moravcsik Edith
Published: November 2019

In this paper, variation is defined as a type having more than one subtype. Using twelve examples from linguistics, two kinds of accounts are identified: eliminating variants and motivating them. Eliminating variants means a subtype is promoted to a type. Motivating variation in turn involves acknowledging the existence of the variants and explaining their existence either by reference to their differing meanings or by identifying the different contexts they occur in. The general applicability of these two ways of dealing with variation is shown by examples from other fields of study and from everyday life.
Musik und Moral: Intertextuelle Bezüge zwischen Lact.inst.6,21 und Sen.epist.123,9 f.
Authors: Speyer Kathrin
Published: November 2019

The goal of this article is to use structural, lexical and content analysis to make the case that the Church Father Lactantius, when composingDivinae institutiones6,21, engaged with Sen.epist.123,9 f. and pointedly refers to it. In the process, this whole chapter of Lactantius will be examined to see what the relation is between the decisive influence of the Seneca passage and that of other pre-texts that have already been identified as such in existing publications, especially the works of other Church Fathers. The content under discussion concerns the risks of purely instrumental music compared to those of artistically designed speech for the spirit of the listener, closely linked to the question of whether Christian writings, too, may – or even should – be aesthetically appealing. The treatment of this question leads ultimately to a general discussion of the relation of pleasure to virtue in the sense of a life pleasing to God.
Unexpected isolation of a cyclohexenone derivative
Authors: Voss Jürgen , Röske Rüdiger , Ehrlich Gunnar , Adiwidjaja Gunadi
Published: November 2019

Knoevenagel reaction of pivaloylacetone with formaldehyde and subsequent aldol condensation ends up with 3-methyl-4,6-dipivaloylcyclohex-2-enone. The structure of the product is proved by an X-ray structure determination.
Examination of the Effects of Homogeneity and Anisotropy on Coating Thickness and Properties in Reinforced Carbon–Carbon by Eddy Current Testing
Authors: Meng Qifeng , Song Kai , Zhang Lipan , Li Yiming , Wei Yali
Published: November 2019

Silicon carbide coating is widely used in various industrial fields and plays an important role in protecting carbon fiber composite materials. Meanwhile, coating thickness is directly related to the performances of the functional coating and the substrate. Therefore, accurate coating thickness inspection and substrate property research are extremely valuable. Based on eddy current testing, this study investigated the effects of homogeneous electromagnetic properties and anisotropic conductivities on the performance of carbon fiber composite with different coating thicknesses. This investigation was conducted by simulating a three-dimensional finite element model of carbon fiber substrate–silicon carbide coating by ANSYS. Results showed that under homogenous conductivity of carbon fiber composite, the voltage values of the detection coil array were symmetrical about the axis of the excitation coil. Therefore, this property avoids detecting the repeatability of measurement data and shorts processing time to improve detection efficiency. Simultaneously, the change in mutual resistance exhibited a positive correlation with increased coating thickness. This trend was similar to that of the self-resistance of the excitation coil in anisotropic conductivity. Furthermore, the self-resistances of the excitation coil in anisotropy and the coating thickness meet a formula. Furthermore, supposing the carbon fiber composite material was in the x-axis direction, the electromagnetic signal was exactly opposite to the y-axis direction perpendicular to the x-axis.
Smart Scheduling of a Batch Manufacturer’s Operations by Utilization of a Genetic Algorithm to Minimize Electrical Demand
Authors: Brimley Paige , Machalek Derek , Powell Kody M.
Published: November 2019

Power utilities currently manage unpredictable electrical demand through the use of fast-ramping plants and punitive demand fees. Unpredictable demand makes it more difficult to onboard variable renewable energy sources, such as solar and wind, because of their intermittency, which can contribute to grid instability. Optimal utilization of variable renewable energy sources requires a flexible, resilient electrical grid and thus a transformation of the current system to a proposed “smart grid” that would adapt in real time to grid signals. Batch manufacturers are well suited to reduce the burden of intermittency by considering demand side management techniques when scheduling process operations. The goal of such participation is a reduction in electrical demand and associated costs for both the facility and the utility. This study investigates how a novel application of the genetic algorithm could be used to schedule a batch manufacturer’s operations in a manner that reduces overall peak demand and is compatible with process constraints. The genetic algorithm is chosen because it is highly efficient at finding minima and handling complex constraints and large data sets. A major highlight of this article is the use of measured demand profiles to log real-time energy consumption of process equipment. The scenarios investigated use a genetic algorithm to determine the optimum scheduling when given a fixed set of interdependent operations that must be executed within the day. All investigated scenarios have a reduction in peak demand after rescheduling via the genetic algorithm. Baseline operations demonstrated reductions between 13 % and 28 %, with an average reduction of 21 %. The results of this study demonstrate that automated load shifting can easily be applied to an industrial facility and paves the way for future work to investigate the integration of scheduling algorithms with process control systems.
Proposta de metodologia para medição da potência necessária ao corte por um triturador florestal
Authors: Machado Antônio Lilles Tavares
Published: November 2019

Para execução do processo de raleamento na Caatinga é importante utilizar máquinas do tipo rotores trituradores acoplados em tratores de baixa potência, visando a diminuição de tempo e mão-de-obra dos agricultores familiares na, implantação de sistemas de exploração sustentáveis, sistemas agrossilvipastoris. Para o projeto de uma máquina que seja acessível a estes produtores, o primeiro passo é se conhecer a potência de corte necessária para a operação de raleamento. O objetivo deste trabalho foi desenvolver e avaliar uma metodologia de ensaio para medir a potência durante o corte de uma espécie arbórea, podendo assim avaliar os parâmetros a serem utilizados futuramente no projeto da máquina. Como espécie teste, utilizou-se o eucalyptus citriodora, por ser uma madeira que apresenta resistência de corte elevada e similar ao das espécies da Caatinga. Observou-se que a metodologia proposta, ao padronizar os procedimentos, permitiu adquirir de forma rápida e precisa os valores dos parâmetros de importância no projeto de máquinas destinadas a cortar e triturar espécies arbóreas. Também a utilização dos dados obtidos por meio da aplicação da metodologia, possibilitam maior confiabilidade e precisão no projeto de máquinas destinadas a este tipo de trabalho.
ÍNDICES DE FRAGILIDADE AMBIENTAL PARCIAIS DA BACIA DO RIO IRAIZINHO
Authors: Da Silva Luís Fernando , Mlenek Dyeison Cesar , Leandro Diuliana , Quadro Maurizio Silveira , Da Rocha Felipe Cunha , Nadaleti Willian Cezar , Castro Andréa Souza
Published: November 2019

A Bacia do Rio Iraizinho, localizada na região Metropolitana de Curitiba, no decorrer da última década, passou por um processo de desenvolvimento urbano e aumento populacional intenso, como consequência, mudanças ambientais bruscas. Nessa região os conflitos ambientais são visíveis, especialmente devido ao surgimento de áreas de riscos face à intensificação da industrialização sobre as áreas de mananciais. Desta forma, esta bacia, vem se tornando cada vez mais frágil e suscetível aos processos de degradação. Neste trabalho se desenvolveu a geração de mapas de índice de fragilidade ambiental parciais utilizando a metodologia IFA (Índice de Fragilidade Ambiental), na qual utilizou conhecimentos das Ciências Geodésicas e áreas afins, visando gerar mapas para o cálculo de fragilidade ambiental para subsídio a políticas de planejamento e gestão para a bacia do Rio Iraizinho. Mapeou-se os temas: Ação antrópica, App´s (Áreas de Preservação Permanente), Clima, Cobertura vegetal, Declividade, Rochas e Solo.
Cinética e equilíbrio secular das principais séries radioativas e suas implicações ambientais
Authors: Nadaleti Willian Cézar , Nege Kassem , Filho Paulo Belli , Andreazza Robson , Quadro Maurizio , Correa Erico Kunde , Correa Luciara , Leandro Diuliana , Vieira Bruno
Published: November 2019

A população está continuamente sujeita aos problemas causados pela radiação, o contato com materiais naturalmente radioativos é diário. Essa exposição prolongada pode causar sérios problemas a saúde. Nesse sentido, esse trabalho faz uma revisão da literatura sobre as principais formas de radiação a que o homem está submetido, abordando o decaimento radioativo dos principais elementos como urânio, tório e rádio. É realizado uma revisão sobre as principais Ações de prevenção à radiação, e por fim é proposto uma transposição didática sobre o ensino de física moderna, tendo como foco a utilização de objetos educacionais dentro da sala de aula.
Automatização do sistema de cálculo de áreas topográficas através do uso combinado de programas de computador
Authors: Garré Saulo De Oliveira , Weymar Guilherme Jahnecke
Published: November 2019

O propósito central deste trabalho foi desenvolver um sistema de interação com o usuário que gerasse a redução do tempo de cálculo de áreas durante o desenvolvimento de mapas topográficos. Para tanto, programou-se uma comunicação entre AutoCAD Map 3D®, ArcGIS® e Excel® (versão para estudantes e educadores), a qual possibilitou a troca de informações necessárias para a geração automática da planilha de cálculo. Para avaliar o desempenho da solução apresentada, fez-se um comparativo entre o Método Tradicional e o Método Automatizado. Nestes, para a geração do mapa, o operador separa as áreas (Campo Nativo, Estrada, Área Úmida, Campo Limpo, entre outras) em polígonos individuais que são exportados para o ArcGIS o qual efetua o cálculo da área de cada polígono e informa os valores obtidos. Estes resultados são posteriormente inseridos manualmente (Método Tradicional) ou automaticamente (Método Automatizado) na planilha de cálculos do AutoCAD Map 3D. Nesta análise, feita por meio de cronometragem, concluiu-se que o Método Automatizado reduziu em 67% o tempo de cálculo.  Espera-se um percentual de redução no tempo de cálculo ainda maior, quando o operador trabalhar com mapas topográficos de alta complexidade, uma vez que estes necessitam de maiores detalhamentos e apresentam diversificações de características. Descreve-se todo o procedimento com o intuito de que a solução abordada possa ser utilizada em problemas distintos.
Synaptic Inhibition of Medial Olivocochlear Efferent Neurons by Neurons of the Medial Nucleus of the Trapezoid Body
Authors: Torres Cadenas Lester , Fischl Matthew J. , Weisz Catherine J.C.
Published: November 2019

Medial olivocochlear (MOC) efferent neurons in the brainstem comprise the final stage of descending control of the mammalian peripheral auditory system through axon projections to the cochlea. MOC activity adjusts cochlear gain and frequency tuning, and protects the ear from acoustic trauma. The neuronal pathways that activate and modulate the MOC somata in the brainstem to drive these cochlear effects are poorly understood. Evidence suggests that MOC neurons are primarily excited by sound stimuli in a three-neuron activation loop from the auditory nerve via an intermediate neuron in the cochlear nucleus. Anatomical studies suggest that MOC neurons receive diverse synaptic inputs, but the functional effect of additional synaptic influences on MOC neuron responses is unknown. Here we use patch-clamp electrophysiological recordings from identified MOC neurons in brainstem slices from mice of either sex to demonstrate that in addition to excitatory glutamatergic synapses, MOC neurons receive inhibitory GABAergic and glycinergic synaptic inputs. These synapses are activated by electrical stimulation of axons near the medial nucleus of the trapezoid body (MNTB). Focal glutamate uncaging confirms MNTB neurons as a source of inhibitory synapses onto MOC neurons. MNTB neurons inhibit MOC action potentials, but this effect depresses with repeat activation. This work identifies a new pathway of connectivity between brainstem auditory neurons and indicates that MOC neurons are both excited and inhibited by sound stimuli received at the same ear. The pathway depression suggests that the effect of MNTB inhibition of MOC neurons diminishes over the course of a sustained sound.

SIGNIFICANCE STATEMENTMedial olivocochlear (MOC) neurons are the final stage of descending control of the mammalian auditory system and exert influence on cochlear mechanics to modulate perception of acoustic stimuli. The brainstem pathways that drive MOC function are poorly understood. Here we show for the first time that MOC neurons are inhibited by neurons of the MNTB, which may suppress the effects of MOC activity on the cochlea.
The implications of social subjectivity in value orientations of Ukrainian capitalists
Authors: Rakhmanov Oleksandr
Published: November 2019

The article analyzes the implications of social subjectivity in value orientations of large owners of Ukraine. Social subjectivity of large capital owners due to personal characteristics that were formed in the school years. In the value orientations of large owners declared their own self-awareness that they are the social basis of national sovereignty.
Geopolitical orientation of Ukrainian capitalists mainly focused on Ukraine’s integration with the European Union.
Professional self-determination of school’s young people as a process: the empirical analysis
Authors: Sappa Ganna-Mariia
Published: November 2019

In the article the analysis of results of research of process of professional self-determination of school’s young people is conducted. The condition of professional self-determination of school’s young people changes from a stage to a stage and represents the difficult formation inherent in the certain age period. Changes in consciousness of the person concerning a choice of sphere of professional work become result of process of professional self-determination. These changes pass gradually and during process conduct the person to formation of its professional interests, requirements, and, finally, to a conscious choice of profession.
Infección paravertebral posacupuntura: reporte de un caso y revisión bibliográfica. [Post-acupuncture paravertebral infection: case report and literature review]
Authors: Besse Micaela , Sarotto Aníbal , Rosado Pardo Jose A. , Cubecino Adriana E.
Published: November 2019

La acupuntura es una técnica de origen chino que surge hace aproximadamente 2000 años. Es una modalidad terapéutica que ha cobrado gran importancia en el mundo occidental para el tratamiento de diversos cuadros, incluida la lumbalgia. Comunicamos el caso de un hombre de 74 años de edad, que consulta por reagudización de la lumbalgia crónica, luego de un tratamiento alternativo, a quien se le diagnostica una complicación infecciosa. Si bien, en manos experimentadas e instruidas, es una técnica con relativamente escasas complicaciones, se han publicado diversos reportes que describen complicaciones, en su mayoría, menores y asociadas a una técnica estéril insuficiente o a falta de conocimiento por parte del acupunturista. El auge de estas técnicas alternativas puso el foco en las medidas de seguridad, por lo cual entes, como la Organización Mundial de la Salud han creado guías para su correcto uso. Conocer las posibles complicaciones facilita el diagnóstico temprano y el tratamiento. Se analiza la presentación clínica y se realiza una revisión bibliográfica del cuadro. AbstractAcupuncture originated in China approximately 2000 years ago and is a growing modality of treatment worldwide sought by patients for a variety of conditions including lumbar pain. We report a case of a 74 years old man who had received acupuncture to treat lower back pain, who subsequently presented an increased in his pain; an infection was diagnosed, and treated. Despite acupuncture can be considered inherently safe in the hands of well-trained practitioners, we found different reports of complications in worldwide literature; most of them minor, and usually as a result of inappropriate technique. The popularity of this alternative treatments, has made organizations, such as World Health Organization (WHO), create guidelines to reassure its safety. The knowledge of the possible complications, allow the early diagnosis and treatment. The case is discussed, and pertinent review of literature is included.
Perception of the Special Jurisdiction for Peace for Incarcerated Members of the Military in the Armed Conflict in Colombia
Authors: Sandoval Garrido Luis Eduardo , Riaño Bermúdez Laura Carolina , Palencia Pérez Armando Sixto
Published: November 2019

With the implementation of the Special Jurisdiction for Peace (JEP), former military soldiers who were because of the armed conflict have been able to reduce sentences and obtain freedom. This document analyses the perception of the JEP by these soldiers based on a survey that identified the type of criminal conviction, the economic and family context, and the perception of the post-conflict for each of the participant soldiers. The results demonstrate that the interviewees consider the main harms of their imprisonment are a family breakdown and unfair treatment between the military and other actors. They hope that being included in the JEP will allow them to have job opportunities and get their families back.
Agroecology and integral microfinance: recommendations for the Colombian post-conflict avoiding the financialization of rural financing
Authors: Ramírez Virviescas Natalia , Monroy Isaza Sergio , Guevara Castañeda Diego Alejandro
Published: November 2019

One of the main challenges for the Colombian post-conflict is to develop sustainable proposals for peasant families that were affected by the armed conflict. With the purpose of analyzing this challenge, after the introduction, the second part of the paper presents the land possession dynamics in Colombia, criticizes the Green Revolution approach and discusses theoretical concerns about agroecology. The third section highlights the importance of combined microfinance in comparison to financialized microfinance, for financing rural projects and agroecology. Furthermore, this part argues that the combination of agroecology and combined microfinance is a powerful tool to make scenarios sustainable for small producers. Finally, the fourth section concludes.
OPTIMIZATION OF CONDITIONS OF EXTRACTION PROCESS FROM COFFEE CHERRY PULP (CASCARA) AND APPLICATION TO DRINKING WATER PRODUCTS WITH ANTIOXIDANT ACTIVITY
Authors: Do Phuong Mai Nguyen , Hoang Quynh Thi Truc , Le Anh Thi Hong
Published: November 2019

The paper studied on the optimization of extraction condition of total polyphenols and flavonoids from dried coffee cherry pulp (Cascara) by response surface methodology. The effect of extraction conditions such as solvent (water)-to-material ratio (X1); temperature (X2) and time (X3) were studied. The results showed that the best combination of extraction conditions for dried coffee cherry pulp was at 1: 40.77 solid- sovent ration, 71.59oC and 48.39min. At optimal extraction conditions, total polyphenol content achieved 23.816 mgGAE/g and total flavonoid 11.365 mgQE/g of dry basis.Applying the optimization conditions of extraction process to drinking water products from coffee cherry pulps and implementing sensory methods according to the ranking test method to determine the mixing formula. Results obtained syrup ratio 90bx, citric acid content is 0.01%. According to the consumer acceptance test, the final product of this research was rated 4.7 on a scale of 7, the studied product has good organoleptic properties and sterilization standards, ensuring food safety for consumers. Our research results indicated potential of using dried coffee cherry pulp (Cascara) as promisisng resources for extracting natural antioxidants.Key words: coffee cherry pulp, Cascara, polyphenol, flavonoid…
ASSESSING CONSUMER BEHAVIOR TOWARDS FISH SAUCE PRODUCTS BY USING FOOD CHOICE QUESTIONNAIRE
Authors: Linh Le Thuy , Tam Le Minh , Ai Vuong Diu , Dzung Nguyen Hoang
Published: November 2019

This study aims to assess Vietnamese consumer behavior towards fish sauce product. It consists of two experiments. In the first experiment, consumer concept was explored using word association method. It was performed on 300 Vietnamese consumers with the prompt word as “fish sauce”. The data were analyzed by a triangulation method. The results evoke six factors associated with fish sauce as Sensory Appeal, Health, Price, Convenience, Traditional Value, Quality and Safety. These findings were the starting point for a modification of food choice questionnaire (FCQ) adapted to fish sauce product. In the second experiment, the modified FCQ with 18 items was used to assess the consumer behavior. The survey was performed on 300 Vietnamese consumers. The data were analyzed by using Exploratory Factor Analysis and Confirmatory Factor Analysis. The obtained model with five factors was adapted to fish sauce for Vietnamese consumers ( = 1.67, GFI = 0.93, CFI = 0.92, RSME = 0.47). In this, Sensory Appeal is the most important factor which might affect consumer food choice motivations. We expect that these results will be useful for the local manufacturers who want to develop traditional food products and/or enlarge national market.
Optimization of Extraction of Total Phenolic and Total Flavonoid from Seeds of Alpinia blepharocalyx K. Schum. Using The Response Surface Methodology
Authors: Nguyen Thanh Tan , Mai Huyen Thi Thanh , Nguyen Tuan Ngoc , Tran Quang Dinh , Tran Thang Dinh
Published: November 2019

Seeds of Alpinia blepharocalyx contain high amounts of phenolic and flavonoid compounds with potential antioxidant properties. In this study, the effects of the extraction method on the recovery of phenolic and flavonoid compounds from Alpinia blepharocalyx seeds were investigated. Response surface methodology (RSM) has been used to optimize the extraction conditions of total phenolic and total flavonoid from seeds of Alpinia blepharocalyx. A Box-Behnken design was used to investigate the effects of four independent variables, namely extraction temperature (°C), extraction time (min), (v/m) and ethanol concentration (%) on the responses: total phenolic content (TPC) and yield. The optimal conditions obtained from response RSM were 52.66 % v/v for the solvent composition, 62.34 (°C) for extraction temperature, 34.48/1 (ml/g) for solvent/material ratio and 125.42 (min) for extraction time. The experimental values of TPC, TFC and yield were 39.31±0.05 mgGAE/g, 12.75±0.07 mgCE/g and 6.97±0.05%, respectively.
VOLATILE COMPOSITION, ANTIOXIDANT PROPERTY AND ANTIMICROBIAL ACTIVITIES AGAINST FOOD-BORNE BACTERIA OF VIETNAMESE THYME (Thymus vulgaris L.) ESSENTIAL OIL
Authors: Quynh Cung Thi To , Trang Vu Thu
Published: November 2019

The essential oil (EO) obtained from the leaves of the thyme (Thymus vulgaris L.) grown in Vietnam was found to contain thymol (39.79%), cymene (17.33%), and γ-terpinene (13.45%) as the main volatile components. The antimicrobial activities of this oil were screened against several food-borne bacteria and fungi species. Significant growth inhibition effects against food-borne bacteria Escherichia coli, Staphylococcus aureus, Bacillus cereus, and Salmonella Typhimurium were observed using the standard disc diffusion method. Thyme EO showed the antibacterial effect against all the test pathogenic strains with the inhibition zones were 23.3 ± 0.4 mm, 24.7 ± 0.4 mm, 29.0 ± 0.7 mm, 32 ± 0.7 mm in diameter against B. subtilis,  E. coli, S. Typhimurium and S. aureus, respectively. The minimum inhibitory concentration (MIC) determined by micro-dilution method in MHB liquid medium was 1.56 µl/ml. The bactericidal concentrations (MBC) was 3.13 µl/ml for three isolates from B. subtilis,  E. coli, and S. aureus, while the MBC tested for S. typhi was 1.56 µl/ml. The antifungal properties of the thyme EO were also determined in this study against three important pathogenic fungi such as Candida albicans, Rhizoctonia solani and Fusarium oxysporum with the inhibition zones ranging approximately from 23.20 ± 0.06 to 44.10 ± 0.03 mm. On the other hands, the results also showed the antioxidant activity of Vietnamese thyme EO and suggested that thyme EO can be applied in food industries as natural flavoring preservatives/additives to control food spoilage and food born bacteria and fungi.
OPTIMAL FERMENTATION CONDITIONS FOR ANTIBIOTIC PRODUCTION BY ENDOPHYTIC Streptomyces cavourensis YBQ59 ISOLATED FROM Cinnamomum cassia Presl
Authors: Nguyen Vu Thi Hang , Nguyen Quang Huy , Hang Le Thi Thu , Chu-Ky Son , Phi Quyet Tien
Published: November 2019

This study determined the optimal nutrient and environmental conditions for the production of antimicrobial and cytotoxic agents by Streptomyces cavourensis YBQ59 during the fermentation process. The antimicrobial and cytotoxic activities of eluted fractions based gradient solvents via silica gel column of chromatograph were also evaluated. S. cavourensis YBQ59 exhibited strong, board-spectrum antimicrobial activities under fermentation conditions as follows: MT6 medium with soluble starch and soybean powder as carbon and nitrogen sources, respectively, temperature 30oC, initial pH 7.0, 20% DO concentration and with 5% initial seed culture. The kinetic of fermentation showed that the antimicrobial and cytotoxic activities were highest at between 72h and 78h. The fraction 25/1 D-M (dichloromethane –methanol) exhibited the highest antimicrobial effect against methicillin-resistant Staphylococcus aureus ATCC 33591 and methicillin-resistant Staphylococcus epidermidis ATCC 35984 with minimum inhibitory concentrations of 9.4 µg/ml and 6.4 µg/ml, respectively. The fraction 10/1 D-M had strong cytotoxic effects towards multidrug-resistant A459 and H1299 lung carcinoma cell lines with the cell viability of 11.3% and 12.4%, respectively. In conclusion, S. cavourensis YBQ59 would be a potential producer of valuable bioactive compounds that may have a board application in pharmaceutical industry and agriculture (biocontrol, livestock, food safety and quality management)
La gestión eficaz en educación y su importancia en acción gerencial educativa de Colombia.
Authors: Parra-Martínez Jaime Enrique
Published: November 2019

El presente artículo indaga ¿Cuáles características de la gestión eficaz identifican la escuela en el mundo contemporáneo?,¿Cómo se pueden aplicar estas características en la realidad de la educación básica secundaria en Colombia? Al realizar una revisióndocumental se encontró que la gestión eficaz procede de estudios desde 1966 desde la difusión del informe Coleman, varios modelos hantratado de ampliar, diversificar y contraponerse a este aporte, encontrando ejemplos de la escuela eficaz y docencia eficaz. En el caso deColombia, la realidad llevó a reconocer la preponderancia de la gestión técnico-instrumental con diferencias entre la relación teoría- práctica yel aprecio más hacia el producto que el proceso. Por eso se propusieron opciones gerenciales y didácticas en favor de la formación integral delestudiante, la valoración del componente humano, sus potencialidades, habilidades y aprendizaje, relevancia del contexto, trabajo en equipo,consenso y comunicación horizontal, formación del director en gerencia.
İSKEMİK MİTRAL YETMEZLİKTE KAPAK REPLASMANI VE TAMİR SONUÇLARININ KARŞILAŞTIRILMASI
Authors: BAŞAR Veysel , ÜNAL Ertekin Utku , TÜTÜN Ufuk , İŞCAN Hakkı Zafer , BİRİNCİOĞLU Cemal Levent
Published: November 2019

Amaç: İskemik kalp hastalığına bağlı
gelişen mitral yetmezlik, halen operatif mortalitesi yüksek
seyirli bir hastalıktır. Cerrahi prosedür olarak halen bir fikir birliği
sağlanmamıştır. Bu çalışmada
İskemik Mitral Yetmezlikte (İMY), mitral kapak replasmanı (MVR) ve tamir sonuçlarının
karşılaştırılarak, birbirlerine üstünlüklerini ortaya koymak amaçlanmıştır.

Materyal ve Metod: 2007
ve 2011 yılları arasında Türkiye Yüksek İhtisas Eğitim ve Araştırma Hastanesi’nde,
İMY nedeniyle opere edilen 36 hasta incelenmiştir. Hastaların (38.9%) kadın, 22’si
(61.1%) erkekti. 20 hastaya MVR, 16 hastaya mitral rekonstrüksiyon yapıldı. Her
iki

grupta bütün vakalarda
koroner bypass mevcuttu. Hastalarda preoperatif risk faktörleri, mitral yetersizliğin
derecesi, sol ventrikül ejeksiyon fraksiyonları, pre-postoperatif fonksiyonel
klasifikasyonları, aort kros klemp ve kardiyopulmoner bypass süreleri, yoğun bakım ve hastane kalış
süreleri belirlendi. Bulgular: MVR yapılan grupta
preoperatif diyastolik çap ve kontrol diyastolik çap arasında anlamlı
olarak fark saptanmıştır (p=0.016). Bu grupta diyastolik çaptaki düzelme tamir grubuna
göre istatistiksel olarak daha iyi çıkmıştır. Ayrıca preoperatif fonksiyonel
kapasite

(FK)
ve kontrol FK arasında, düzelme yönünde anlamlı fark bulunmuştur (p=0.008).
Erken dönem
mortalite görülen hastalar incelendiğinde MVR yapılan grupta 6 hasta, tamir grubunda
5 hasta exitus oldu. Mortalite görülen 11 hasta ile sağ kalan hastalar
preoperatif ejeksiyon
fraksiyonu (EF) yönünden karşılaştırıldığında anlamlı bir fark bulunmamıştır.  (p=0.986)

Sonuç: İMY‘de
öncelikle mitral tamir önerilse de, son zamanlarda bazı çalışmalarda da önerildiği
gibi, MVR yapılması mitral yetmezliğin tam giderilmesini sağlayıp, reoperasyon riskini
azaltmaktadır.
A Study on Influence Relation of Flight Search Mobile Application Users’ Perceived Benefit, Perceived Sacrifice, Perceived Value and Continuous Use Intentions by Using Value-based Adoption Model
Authors:   The Tourism Sciences Society Of Korea, Choi Kyung-Ok , Lee Hyung-Ryong
Published: November 2019

The purpose of this study was to apply a value-based acceptance model to consumers with experience in searching and purchasing tickets using a flight ticket search mobile app to understand the perceived benefits and sacrifices of the app and its impact on perceived value and continued use. Based on the results of the research, important insights can be seen concerning consumer behavior regarding flight ticket search mobile app services and the provision of useful data for the marketing strategies of companies that provide the service. This study used 428 effective samples for empirical analysis from Koreans in their 20s to 40s with experience in searching and purchasing tickets through a flight ticket search mobile app. For the research analysis, reliability analysis, confirmatory factor analysis, and correlation analysis were performed using SPSS 22.0 and AMOS 22.0, and a structural equation model was done to verify the causal relationship between the component concepts. The results show that usefulness, ease, and enjoyment of the ticket search mobile app had a significant positive effect on perceived value, and that perceived value also had a significant positive effect on the continuous use intention. However, it was found that privacy risks and resistance to innovation had no significant negative effect on perceived values.
Free vascularized femoral condyle bone graft in treatment of tubular bone nonunions
Authors: Golubev I. O. , Kukin I. A. , Merculov M. V. , Shiryaeva G. N. , Bushuev O. M. , Kutepov I. A. , Sautin M. E. , Balura G. G. , Sarukhanyan A. R.
Published: November 2019

Vascularised bone graft from femoral condyles are relatively new method in treatment of bone nonunions, small bone defects and loss of articular cartilage. In this article experience of using of vascularized bone grafts from medial and lateral femoral condyles, operation technique and clinical cases with long-term results were described. In conclusion, authors generated basic indications for free vascularized bone grafts from femoral condyles.
Lumbosacral pain in athletes and ballet dancers: spondylolysis and spondylolisthesis
Authors: Mironov S. P. , Burmakova G. M. , Orletsky A. K. , Tsykunov M. B. , Andreev S. V.
Published: November 2019

Purpose of research. Development of diagnostic algorithm for lumbosacral pain syndrome (PCBS) caused by spondylolysis and spondylolisthesis of III degree in athletes and ballet dancers. Material and methods. 212 patients athletes and entertainers of BA - summer with PCBS caused by spondylolysis (171 persons) and spondylolisthesis of III degree (41 persons) of lumbar vertebrae were under observation. Clinical and neurological, x-ray studies, ultrasonography, computed tomography, scintigraphy, as well as the study of markers of bone tissue re - sorption (calcium in urine) and bone formation (alkaline phosphatase) were carried out. Results. Clinical manifestations spondylolysis malespecific (pain after exercise); with the progression of instability and incipient spondylolisthesis pain, strengthening - esja at sharp movements, increased muscle tone of extensors of the back and the rear muscle groups of the thigh. Decisive in the diagnosis are radiological methods. Information content of standard spondylograms is 84.6%), functional-96.7%. To clarify the localization, the size of the arc defect, as well as in subsequent control examinations, an additional study is carried out in 3/4 projections (information content of 99.2%). A highly sensitive informative method is scintigraphy, which allows to determine the presence of bone tissue rearrangement in the first days after the injury. The focus of hyperfixation, or Vice versa, hypothically radiopharmaceutical characteristics would constitute an increase or decrease of metabolic processes. With the help of scintigraphy, you can track the dynamics of reparative processes and determine the timing of the resumption of professional activities. Ultrasonography also helps to detect instability in the vertebral segment in the early stages of its development and monitor the dynamics in the treatment process. Detection of osteopenia evidence of a violation of bone metabolism, which must be considered in the treatment-be sure to use drugs that affect bone metabolism and calcium homeostasis. Conclusion. The combination of standard, functional radiographs, as well as x-rays in oblique projections and scintigraphy is quite adequate for the diagnosis of splondylolysis, spondylolisthesis and the detection of instability in athletes and ballet dancers.
An alternative solution to the problem of “cold welding” the adapter of the modular head with the cone of the stably osseointegrated femoral component of the M2a-Magnum implant, when choosing the volume of revision endoprosthetics
Authors: Zagorodni N. V. , Kudinov O. A. , Ayusheev D. B. , Shelpyakov K. D.
Published: November 2019

The main advantages of the М2а-Magnum modular system pair are the presence of a group of metals metal with wear of the large head, which is the maximum value that makes it possible to increase the range of motion in the hip joint by more than 160 with virtually no risk of dislocation [1]. This allows you to freely conduct active work and sports. However, the system is not without drawbacks. First of all, this is the unrevealed danger of damage to metal ions in the blood, as well as the problem of the development of a pseudotumor lymphoid reaction [2,3], leading to extensive osteolysis, an increased risk of periprosthetic fractures, and, accordingly, an increase in the frequency of endoprosthesis destabilization. Currently, the use of constructions is practically suspended, but there are more than 1 million patients in the world [4] with implanted large "metals - metal pairs". In revision surgery with M2a-Magnum implants, the main problem is often the inability to remove the femoral head adapter component from the neck taper. fretting corrosion is observed, leading to the effect of cold welding. The latter is typical for the connection of titanium surfaces (adapter of the head module and the neck of the femoral component). It turns out that it should be noted that the M2a-38 system does not have a titanium adapter made of a cobalt-chromium alloy and devoid of this problem [4].
Clinical historical aspects of treatment of hallux valgus (part I)
Authors: Gudi S. M. , Epishin V. V. , Korochkin S. B. , Kuznetsov V. V. , Samokhin A. G. , Pakhomov I. A.
Published: November 2019

Treatment of patients has been accumulated with deformity of the first ray of the foot has a long history and vast experience in this area of orthopedics. The clinical histories of the review of the treatments evolution of patients are presented with Hallux valgus. The ways of development and improvement of the basic methods are described in the historical plan with an estimation of their advantages and lacks.
Three Gustave Moreau Pictures: Myth, Religion, Creativity
Authors: Sertakova Ekaterina A. , Leshchinskaia Natalia M. , Kolesnik Maria A.
Published: November 2019

This article is devoted to the study of paintings by the famous French artist Gustave Moreau called the “last romantic”. Gustave Moreau was one of the main representatives of the symbolism, formally and factually realizing its principles in his works. The article explores the relationship of mythology, religious and creative ideas in Gustave Moreau’s paintings on the basis of philosophical and cultural analysis of his three paintings, demonstrating the image of the poet. A research into the painter’s works revealed the essence of the Gustave Moreau’s creative process and specified the potential of further analysis of the myth-making in art.