bluuebunny/crossref_metadata_2025 huggingface dataset:
Ictiose congênita de Arlequim: relato de um caso
Authors: Renner Fabiani Waechter , Costa Bruna Polanski , Figueira Fernanda Pitelkow , Ebert Jéssica Pinto , Nascimento Leonardo Silveira , França Victória Teles , Oliveira Allana Maychat Pereira
Published: September 2019

Introdução: a ictiose congênita de Arlequim é uma desordem rara constituída de herança autossômica recessiva, caracterizada pelo espessamento da pele de toda a superfície corporal. Relato do caso: apresentamos um caso de diagnóstico ecográfico pré-natal de ictiose de Arlequim, que evoluiu com óbito intrauterino. Conclusão: esse distúrbio caracteriza-se por um neonato envolto por uma membrana espessa de material córneo com fissuras generalizadas, comprometendo as funções básicas da pele e predispondo o recém-nascido a infecções e a alterações metabólicas. Com prognóstico desfavorável, o diagnóstico precoce e o tratamento de suporte visam aumentar a sobrevida e melhorar a qualidade de vida ao neonato.
Ήταν ο Νικόδημος Αγιορείτης ο συνομιλητής του Villoison στον Άθω το 1785 ή άλλος ομώνυμος μοναχός;
Authors: Φραγκίσκος Εμμ. Ν.
Published: September 2019

No abstract
Topoisomerases and cancer chemotherapy: recent advances and unanswered questions
Authors: Bjornsti Mary-Ann , Kaufmann Scott H.
Published: September 2019

DNA topoisomerases are enzymes that catalyze changes in the torsional and flexural strain of DNA molecules. Earlier studies implicated these enzymes in a variety of processes in both prokaryotes and eukaryotes, including DNA replication, transcription, recombination, and chromosome segregation. Studies performed over the past 3 years have provided new insight into the roles of various topoisomerases in maintaining eukaryotic chromosome structure and facilitating the decatenation of daughter chromosomes at cell division. In addition, recent studies have demonstrated that the incorporation of ribonucleotides into DNA results in trapping of topoisomerase I (TOP1)–DNA covalent complexes during aborted ribonucleotide removal. Importantly, such trapped TOP1–DNA covalent complexes, formed either during ribonucleotide removal or as a consequence of drug action, activate several repair processes, including processes involving the recently described nuclear proteases SPARTAN and GCNA-1. A variety of new TOP1 inhibitors and formulations, including antibody–drug conjugates and PEGylated complexes, exert their anticancer effects by also trapping these TOP1–DNA covalent complexes. Here we review recent developments and identify further questions raised by these new findings.
A survey on the occurrence of Brachyspira pilosicoli and Brachyspira hyodysenteriae in growing-finishing pigs
Authors: Dors Arkadiusz , Czyżewska-Dors Ewelina , Woźniakowski Grzegorz
Published: September 2019

Background: The major pathogenic intestinal spirochetes affecting pigs during the growing- finishing stage of production includeBrachyspira hyodysenteriaeandBrachyspira pilosicoli. Infections by these pathogens, which affect the economics of pig production, can result in mortality, growth rate losses and substantial antibiotic costs. The aim of this study was to assess the current occurrence ofB. hyodysenteriaeandB. pilosicoliin Polish pig herds. Moreover, associations between the presence of diarrhea or other intestinal pathogens and occurrence ofB. hyodysenteriaeandB. pilosicoliin pigs were investigated.

Methods: Between January 2017 and August 2019, a total of 401 samples of pig feces from 95 different herds were submitted to the National Veterinary Research Institute of Poland. These samples were obtained from pigs older than 7 weeks. All the received fecal samples were examined for the presence ofB. hyodysenteriae,B. pilosicoliandLawsonia intracellularisby real-time PCR.

Results: ForB. pilosicoli,4.5% (95% CI, 2.5–7.0%) of samples and 13.7% (95% CI, 7.5–22.3%) of herds were positive. Out of 12 samples,B. pilosicoliwas detected simultaneously withL. intracellularis,B. hyodysenteriaeandB. pilosicoliwere detected alone in two samples each. In terms ofB. hyodysenteriae,7.0% of samples (95% CI, 4.7–9.9%) from 18.9% of herds (95% CI, 11.6–28.3%) were positive in real time PCR. The presence ofB. hyodysenteriaein fecal samples was associated with the presence of diarrhea in pigs.

Conclusions: This study confirmed thatB. pilosicoliinfections occur in Polish pig herds, but the prevalence is at a low level and the presence ofB. pilosicoliis not associated with the development of diarrhea in pigs.B. hyodysenteriaeis still a common cause of diarrhea among pigs from Polish herds.
Effect of large-scale inhomogeneity of solar wind velocity on distribution of directions of interplanetary magnetic field vector
Authors: Ерофеев Дмитрий , Erofeev Dmitry
Published: September 2019

Using data with hourly resolution obtained in near-Earth heliosphere in 1965–2014, we have calculated statistical characteristics of the angles describing the direction of the interplanetary magnetic field (IMF): root-mean-square deviations of azimuthal and elevation angles, asymmetries of their distributions, and coefficient of correlation of the angles. It has been shown that the above characteristics varied in the course of solar cycle, and some of them changed their signs when solar polar magnetic field reversed. The results obtained from the experimental data analysis were compared with a model describing transport of large-scale disturbances of IMF lines by the inhomogeneous solar wind. The comparison has shown that the variations in the angular distribution of IMF in the course of solar cycle probably occur due to the appearance of the large-scale latitudinal gradient of solar wind velocity during solar minima. In addition, the angular distribution of IMF has been found to be substantially affected by the longitudinal velocity gradient in trailing parts of high-speed streams and short-term local-scale variations in velocity gradients.
Diamagnetic structures as a basis of quasi-stationary slow solar wind
Authors: Еселевич Виктор , Eselevich Viktor
Published: September 2019

The results presented in this review reflect the fundamentals of the modern understanding of the nature of the structure of the slow solar wind (SW) along the entire length from the Sun to the Earth's orbit. It is known that the source of the slow quasi-stationary SW on the Sun is the belt and the chains of coronal streamers The streamer belt encircles the entire Sun as a wave-like surface (skirt), representing a sequence of pairs of rays with increased brightness (plasma density) or two lines of rays located close to each other. Neutral line of the radial component of the solar global magnetic field goes along the belt between the rays of each of these pairs. The streamer belt extends in the heliosphere is as the heliospheric plasma sheet (HPS). Detailed analysis of data from Wind and IMP-8 satellites showed that HPS sections on the Earth orbit are registered as a sequence of diamagnetic tubes with high density plasma and low interplanetary magnetic field. They represent an extension of rays with increased brightness of the streamer belt near the Sun. Their angular size remains the same over the entire way from the Sun to the Earth's orbit. Each HPS diamagnetic tube has a fine internal structure on several scales, or fractality. In other words, diamagnetic tube is a set of nested diamagnetic tubes, whose angular size can vary by almost two orders of magnitude. These sequences of diamagnetic tubes that form the base of slow SW on the Earth's orbit has a more general name — diamagnetic structures (DS). In the final part of this article, a comparative analysis of several events was made, based on the results of this review. He made it possible to find out the morphology and nature of the origin of the new term “diamagnetic plasmoids” SW (local amplifications of plasma density), which appeared in several articles published during 2012–2018. The analysis carried out at the end of this article, for the first time, showed that the diamagnetic plasmoids SW are the small-scale component of the fractal diamagnetic structures of the slow SW, considered in this review.
WORKSHOP PENYUSUNAN KARYA ILMIAH BAGI GURU-GURU SMP MUHAMMADIYAH SE-KABUPATEN BANTUL
Authors: Widayati Widayati , Istihapsari Vita
Published: September 2019

Sejumlah guru SMP Muhammadiyah Bantul memiliki kesulitan dalam membuat karya ilmiah. Di sisi lain, karya ilmiah guru merupakan salah satu item dalam penilaian akreditasi sekolah di SMP Muhammadiyah Bantul, selain juga dapat dijadikan bahan kenaikan golongan para guru. Sehingga, dibutuhkan suatu pelatihan yang dapat membantu para guru dalam penyusunan karya ilmiah. Pelatihan dan workshop ini diikuti oleh 20 guru SMP Muhammadiyah Bantul. Adapun tujuan dari kegiatan ini adalah untuk memberi pembimbingan penyusunan pembuatan karya ilmiah kepada guru-guru SMP Muhammadiyah di Bantul. Kegiatan diawali dengan guru melakukan penelitian dalam pembelajaran. Selanjutnya dari hasil penelitian tersebut, guru menyusun karya ilmiah yang dapat dipublikasikan. Metode yang digunakan pada kegiatan ini adalah dengan mengadakan pendampingan kepada guru-guru matematika SMP Muhammadiyah di Bantul dalam pelatihan dan workshop pembuatan penelitian dan menyusun Karya Ilmiah. Hasil angket yang diberikan kepada guru, sebelum dan sesudah mengikuti workshop, diperoleh nilai rata-rata sebelum mengikuti workshop yaitu 33,28 pada kategori cukup, dan nilai rata-rata sesudah mengikuti workshop yaitu 37,09 pada kategori baik. Hasil dari kegiatan ini adalah guru-guru SMP Muhammadiyah di Bantul dapat membuat karya ilmiah yang berkualitas sehingga dapat dijadikan bahan kenaikan golongan maupun penilaian pada akreditasi sekolah.
PELATIHAN PENINGKATAN KOMPETENSI MELAKUKAN BIMBINGAN KELOMPOK BAGI GURU BIMBINGAN DAN KONSELING SMP DI KABUPATEN SLEMAN
Authors: Bhakti Caraka Putra , Hartini Sri , Fauziah Mufied
Published: September 2019

Pelatihan ini bertujuan untuk meningkatkan kompetensi guru bimbingan dan konseling sekolah menengah pertama di kabupaten Sleman dalam aspek pengetahuan, keterampilan pelaksanaan layanan dan keterampilan penyusunan administrasi bimbingan kelompok baik Rencana Pemberian Layanan (RPL) maupun laporan. Pelatihan dilaksanakan menggunakan metode ceramah, workshop, dan role play. Kegiatan pelatihan dilaksanakan di SMPN 1 Ngaglik, dengan jumlah pertemuan empat kali, dengan satu kali pelatihan dilaksanakan selama 8 jam. Peserta pelatihan terdiri dari 31 Guru Bimbingan dan konseling yang berasal dari 31 sekolah di kabupaten Sleman. Teknik bimbingan kelompok yang dilatihkan meliputi teknik diskusi, sosiodrama, psikodrama dan permainan. Setelah kegiatan pelatihan berakhir, peserta memperoleh pemahaman, keterampilan pelaksanaan bimbingan kelompok dengan teknik diskusi, sosiodrama, psikodrama dan permainan serta mempu menyusun rencana dan laporan layanan bimbingan kelompok. Hasil pelatihan yang telah dilakukan meninjau dari dua aspek penilaian, yaitu kemampuan Guru BK dalam menyusun RPL dan kemampuan Guru BK dalam melakukan layanan bimbingan kelompok. Hasil analisis data pelatihan diperoleh bahwa dalam penyusunan RPL peserta kegiatan memperoleh skor rata-rata 35,85 dalam kategori baik. Hal tersebut menunjukkan bahwa peserta pelatihan telah memiliki keterampilan yang baik dalam menyusun RPL (Rencana Pemberian Layanan) bimbingan kelompok. Selanjutnya, hasil analisis data kemampuan peserta dalam melakukan layanan bimbingan kelompok menunjukkan skor 66,96 dalam kategori baik. Hal tersebut menunjukkan bahwa peserta memiliki kemampuan yang baik dalam melakukan layanan bimbingan kelompok.
EDUKASI KESEHATAN KONSUMSI SAYUR DAN BUAH, SERTA PENGELOLAAN SAMPAH PADA ANAKâ€“ANAK SD NEGERI KEMPONG
Authors: Pranungsari Dessy , Anwar Indra Chaerul , Maarifudin Samsul , Arisandi Viki
Published: September 2019

SD Negeri Kempong merupakan satu-satunya sekolah dasar yang terletak di Dusun Kempong, Banjaroyo, Kalibawang, Kulon Progo. Edukasi diikuti sebanyak 25 siswa dari total 64 siswa di SD Kempong. Konsumsi sayur dan buah merupakan salah satu syarat dalam memenuhi menu gizi seimbang. Konsumsi sayur dan buah sangat penting untuk dilakukan oleh anak-anak di setiap kali makan. Konsumsi sayur dapat mempengaruhi tingkat pertumbuhan dan perkembangan anak, khususnya yaitu pada usia 7-9 tahun. Pengetahuan tentang perbedaan sampah organik dan anorganik juga merupakan suatu hal yang penting untuk diajarkan kepada siswa. Hal ini dilakukan dengan tujuan agar siswa mampu menjaga lingkungan dan mengetahui manfaat dari sampah organik dan anorganik. Dengan memberikan edukasi selama 2 hari (12 dan 13 Februari 2019) tentang pentingnya konsumsi sayur dan buah serta perbedaan sampah diharapkan anak-anak dapat mengonsumsi sayur, buah setiap harinya dan dapat menjaga lingkungan agar tetap bersih.
Using figured worlds to explore parents' attitudes and influences for choosing the content of primary school packed lunches
Authors: Jackson Jessica Eve , Giles Dave , Gerrard Clarabelle
Published: September 2019

Objective:

This study aimed to explore parents' attitudes toward the content of their child's packed lunch, school healthy eating policies, and their child's wishes. Furthermore, in this context, it also aimed to explore perceptions of health promotional materials and how these interventions interplayed with issues parents felt were important.

Design:

The ideology of ‘figured worlds’ was used as a stance to consider the relationship between bounding structures within society and the individual positional identity. Focus groups interviews obtained qualitative data of parents' multiple viewpoints. Iterative categorisation was employed as a method of analysis to observed findings in the data in relation to the individuals as intersubjective beings and their behaviour influenced by environmental conditions.

Setting:

A cross selection of local schools and parenting network were approached. Snowballing techniques were implemented highlighting the inclusion criteria.

Subjects:

Participants were required to have a child attending primary school who they provided a packed lunch for on a regular basis.

Results:

Three umbrella themes were identified: ‘The parents ideal’, ‘The child's desires’, and ‘Inconsistencies of the governing school’. A fourth theme, ‘The health promotional intrusion’ provides insight into the parents' reality when being presented with health promotional materials.

Conclusions:

This study has highlighted the complex, conflicting interplay between parents' ideal for their child's diet, their child's desires and the governing approaches to encouraging healthier choices. This understanding is vital when designing specific interventions to meet the needs of individuals, which prevent, protect and promote a healthy lifestyle for children and their families.
The percutaneous endovascular fistula for haemodialysis
Authors: Tullett Karen
Published: September 2019

Karen Tullett, a haemodialysis access clinical nurse specialist, describes the advantages of percutaneously created arteriovenous fistulas for end stage renal failure patients
Ethical concepts: the meaning of consequentialism
Authors: Ellis Peter
Published: September 2019

Healthcare professionals must consider the best interests of their patients. In this article, Peter Ellis explains consequentialism and how it can be applied to the kidney care professional
The Renal Arts Group: a source of creativity and communication
Authors: Johnston William
Published: September 2019

The potential benefits of participating in arts while on dialysis and post-transplant is now being acknowledged. William Johnston, Northern Ireland Advocacy Officer, Kidney Care UK, outlines his own renal arts journey and how the Renal Arts Group (Queens University Belfast) was created and developed, and its contribution to the momentum of the renal arts movement.
‘Down’ cow management
Authors: Mahendran Sophie
Published: September 2019

Assessment and planned delivery of care for a ‘down’ cow can be very challenging, from initial identification of the primary problem through to preventing development of secondary compartment syndrome. Being able to take control of the initial management of a case such as utilisation of deep bedding on top of concrete to provide grip, along with having the confidence to take your time when hoisting an animal can all have a big impact on the final success of a case. This article will explore the different techniques that can be used on farm to care for and manage down cows, along with a discussion of the poor overall prognosis that down cows tend to have.
Mycoplasma bovis infections in dairy calves
Authors: Mason Colin
Published: September 2019

The role of Mycoplasma bovis as a cause of pneumonia, arthritis, conjunctivitis and otitis media in calves, particularly milk fed dairy calves, is well established. The organism can readily be identified from the upper and lower respiratory tracts of both healthy and diseased calves suggesting that asymptomatic carrier or subclinical disease states within calf populations can also occur. Reports from cattle practitioners and disease surveillance data would suggest that the incidence of M. bovis-associated disease in calves is increasing ( APHA Surveillance focus 2018 ). There is much that we do not know about M. bovis infections ( UK Cattle Expert Group, 2018 ). This article will focus on some of what we do know about the organism, the associated diseases and their pathogenesis in milk fed dairy calves and how this knowledge can be best applied for disease prevention and treatment.
Autumn plant poisoning hazards
Authors: Bates Nicola
Published: September 2019

Potentially poisonous plants are a common part of the environment of many farm animals. Risk of poisoning varies season by season and year by year with variation in the environmental conditions. In the autumn there is risk of poisoning from seeds and fruits and autumn flowering plants. This includes plants containing cyanogenic glycosides (such as cherry laurel) and yew which contains taxine alkaloids. These plants commonly cause sudden death in livestock. Oak, although part of the natural diet of many animals, can cause episodic outbreaks of poisoning, particularly following hot, dry summers. Signs mainly involve the gastrointestinal and renal systems. Poisoning with horse chestnut is not common but can cause neurological and gastrointestinal signs. Ingestion of autumn crocus can also cause gastrointestinal signs in livestock. Prevention of poisoning by recognising the risks and limiting potential circumstances of exposure and ensuring access to forage is essential, as treatment options for management of poisoning in livestock are limited and, in some cases, the only sign of exposure is sudden death.
Canine flea control — what the veterinary nurse needs to know
Authors: Paterson Sue
Published: September 2019

Ectoparasite control forms an important part of any routine canine health programme. The veterinary nurse is well placed to advise clients about appropriate flea control starting with their first interaction with a client at the puppy clinic, through to their pet's routine yearly health checks. Nurses with a special interest in dermatology who run practice dermatology clinics also need to advise clients about flea control as part of an integrated strategy to control their pet's skin problems. As such it is important that the veterinary nurse is aware of the life cycle of the flea and the mode of action of the numerous products that are currently available.
Canine diabetes mellitus
Authors: Chapman Stella
Published: September 2019

Canine diabetes mellitus is a complex endocrinopathy, with a pathogenesis that varies amongst individuals, but is clinically similar to Type I diabetes in humans. The aetiology and pathogenesis of the disease remains poorly understood; however, irrespective of the underlying aetiology, diabetes mellitus is reported to occur as a result of the interplay between environmental and genetic factors. Investigation and treatment of canine diabetes will require considerable investment from owners. This will include both financial commitment and considerable time and effort; but this commitment can achieve a good outcome.
The Teaching Profession according to Communication Styles while Solving Conflict Situations
Authors: Kolenova Zuzana , Halakova Zuzana
Published: September 2019

An essential qualification requirement of the teachers´ profession is to handle the conflict situations effectively focusing on cultivation healthy kinds of relationship with other participants of the educational process, keeping discipline, communicative and good teaching atmosphere. In this contribution, we compare styles used in solving the conflict situations insight teaching profession objectively. Slovak elementary school teachers (N = 22) and secondary grammar school teachers (N = 42) were ask to complete a questionnaire consisting of 25 questions with 5 types of solving the conflict situations at school (avoiding, fighting, compromising, accommodating, collaborating). The occurrence and the use of different teachers´ approaches to solving the conflict situation were compared and analyzed. The Likert scaling and the method verified by professor Northouse were used for data evaluation. It is of high importance to pay attention to the dominant style (or the absent one) of solving the conflict situations in the teacher-student, teacher-teacher or teacher-superior interactions and to explore the differences of applying them.
Adaptation of the Test Developed to Measure Mathematical Knowledge of Teaching Geometry in Turkey
Authors: Esendemir Ozan , Bindak Recep
Published: September 2019

“Mathematical knowledge for teaching” is a concept indicating the requirement for a specific kind of knowledge required to teach mathematics. Mathematical knowledge for teaching necessitates a more complex structure than what is required to carry out mathematical tasks and the knowledge to do that. The purpose of this study is to realize the adaptation of “Mathematical Knowledge for Teaching -Geometry (MKT-G)” Test that was initially conceived in English to Turkish (or to Turkish culture). During the adaptation process; after the translations of the items, focus group interviews were held with a group consisting of mathematics teacher educators and experienced mathematics teachers, and then the data from 243 elementary mathematics teachers was analyzed via  Item Response Theory (IRT). As a result of the analysis of the test items, psychometric values of the test items indicated that the items in the test performed well in Turkey. Besides, validity and reliability arguments were also tested. As a result, the Turkish version of the MKT-G test is highly reliable and valid to measure the teachers’ knowledge of teaching geometry.
In vivo assessment of high-molecular-weight polyethylene core suture tape for intra-articular ligament reconstruction
Authors: Soreide Endre , Denbeigh Janet M. , Lewallen Eric A. , Thaler Roman , Xu Wei , Berglund Lawrence , Yao Jie J. , Martinez Anthony , Nordsletten Lars , van Wijnen Andre J. , Kakar Sanjeev
Published: September 2019

Aims

Options for the treatment of intra-articular ligament injuries are limited, and insufficient ligament reconstruction can cause painful joint instability, loss of function, and progressive development of degenerative arthritis. This study aimed to assess the capability of a biologically enhanced matrix material for ligament reconstruction to withstand tensile forces within the joint and enhance ligament regeneration needed to regain joint function.

Materials and Methods

A total of 18 New Zealand rabbits underwent bilateral anterior cruciate ligament reconstruction by autograft, FiberTape, or FiberTape-augmented autograft. Primary outcomes were biomechanical assessment (n = 17), microCT (µCT) assessment (n = 12), histological evaluation (n = 12), and quantitative polymerase chain reaction (qPCR) analysis (n = 6).

Results

At eight weeks, FiberTape alone or FiberTape-augmented autograft demonstrated increased biomechanical stability compared with autograft regarding ultimate load to failure (p = 0.035), elongation (p = 0.006), and energy absorption (p = 0.022). FiberTape-grafted samples also demonstrated increased bone mineral density in the bone tunnel (p = 0.039). Histological evaluation showed integration of all grafts in the bone tunnels by new bone formation, and limited signs of inflammation overall. A lack of prolonged inflammation in all samples was confirmed by quantification of inflammation biomarkers. However, no regeneration of ligament-like tissue was observed along the suture tape materials. Except for one autograft failure, no adverse events were detected.

Conclusion

Our results indicate that FiberTape increases the biomechanical performance of intra-articular ligament reconstructions in a verified rabbit model at eight weeks. Within this period, FiberTape did not adversely affect bone tunnel healing or invoke a prolonged elevation in inflammation. Cite this article: Bone Joint J 2019;101-B:1238–1247.
Patient and implant survival following intraoperative periprosthetic femoral fractures during primary total hip arthroplasty
Authors: Lamb Jonathan N. , Matharu Gulraj S. , Redmond Anthony , Judge Andrew , West Robert M. , Pandit Hemant G.
Published: September 2019

Aims

We compared implant and patient survival following intraoperative periprosthetic femoral fractures (IOPFFs) during primary total hip arthroplasty (THA) with matched controls.

Patients and Methods

This retrospective cohort study compared 4831 hips with IOPFF and 48 154 propensity score matched primary THAs without IOPFF implanted between 2004 and 2016, which had been recorded on a national joint registry. Implant and patient survival rates were compared between groups using Cox regression.

Results

Ten-year stem survival was worse in the IOPFF group (p < 0.001). Risk of revision for aseptic loosening increased 7.2-fold following shaft fracture and almost 2.8-fold after trochanteric fracture (p < 0.001). Risk of periprosthetic fracture of the femur revision increased 4.3-fold following calcar-crack and 3.6-fold after trochanteric fracture (p < 0.01). Risk of instability revision was 3.6-fold after trochanteric fracture and 2.4-fold after calcar crack (p < 0.001). Risk of 90-day mortality following IOPFF without revision was 1.7-fold and 4.0-fold after IOPFF with early revision surgery versus uncomplicated THA (p < 0.001).

Conclusion

IOPFF increases risk of stem revision and mortality up to ten years following surgery. The risk of revision depends on IOPFF subtype and mortality risk increases with subsequent revision surgery. Surgeons should carefully diagnose and treat IOPFF to minimize fracture progression and implant failure. Cite this article: Bone Joint J 2019;101-B:1199–1208
The effect of implant modification
Authors: Pineda Alfredo , Pabbruwe Moreica B. , Kop Alan M. , Vlaskovsky Philip , Hurworth Mark
Published: September 2019

Aims

The aim of this study was to conduct the largest low contact stress (LCS) retrieval study to elucidate the failure mechanisms of the Porocoat and Duofix femoral component. The latter design was voluntarily recalled by the manufacturer.

Materials and Methods

Uncemented LCS explants were divided into three groups: Duofix, Porocoat, and mixed. Demographics, polyethylene wear, tissue ingrowth, and metallurgical analyses were performed.

Results

In 104 implants, a decrease in the odds of loosening and an increase in metallosis and tissue staining in the Duofix group relative to Porocoat group was detected (p = 0.028). There was an increased presence of embedded metallic debris in the Duofix group (p < 0.001). Decreased tissue ingrowth was associated with the Duofix surface (p < 0.001). The attached beads had reduced microhardness, indicative of adverse thermal processing, which resulted in bead shedding, particulate debris, and metallosis.

Conclusion

Hydroxyapatite coating of the LCS femoral component produced unexpected results and led to its recall. The root cause was likely a combination of retained alumina grit and a reduction in bead microhardness (mechanical strength) resulting in increased particle debris, metallosis, and early revision. The Duofix LCS femoral component was not equivalent to the Porocoat version despite its approval through the Food and Drug Administration (FDA) 510(k) equivalance approval process. Regulation of the introduction of modified existing devices needs to be improved and the Duofix LCS should have been considered to be a new device for which equivalence had not been demonstrated at the point of introduction. Cite this article: Bone Joint J 2019;101-B:1248–1255
A higher reoperation rate following arthroplasty for failed fixation versus primary arthroplasty for the treatment of proximal humeral fractures
Authors: Nowak Lauren. L , Hall Jeremy , McKee Michael D. , Schemitsch Emil H.
Published: September 2019

Aims

To compare complication-related reoperation rates following primary arthroplasty for proximal humerus fractures (PHFs) versus secondary arthroplasty for failed open reduction and internal fixation (ORIF).

Patients and Methods

We identified patients aged 50 years and over, who sustained a PHF between 2004 and 2015, from linkable datasets. We used intervention codes to identify patients treated with initial ORIF or arthroplasty, and those treated with ORIF who returned for revision arthroplasty within two years. We used multilevel logistic regression to compare reoperations between groups.

Results

We identified 1624 patients who underwent initial arthroplasty for PHF, and 98 patients who underwent secondary arthroplasty following failed ORIF. In total, 72 patients (4.4%) in the primary arthroplasty group had a reoperation within two years following arthroplasty, compared with 19 patients (19.4%) in the revision arthroplasty group. This difference was significantly different (p < 0.001) after covariable adjustment.

Conclusion

The number of reoperations following arthroplasty for failed ORIF of PHF is significantly higher compared with primary arthroplasty. This suggests that primary arthroplasty may be a better choice for patients whose prognostic factors suggest a high reoperation rate following ORIF. Prospective clinical studies are required to confirm these findings. Cite this article: Bone Joint J 2019;101-B:1272–1279
The Radiographic Union Score for HUmeral fractures (RUSHU) predicts humeral shaft nonunion
Authors: Oliver William M. , Smith Thomas J. , Nicholson Jamie A. , Molyneux Sam G. , White Tim O. , Clement Nick D. , Duckworth Andrew D.
Published: September 2019

Aims

The primary aim of this study was to develop a reliable, effective radiological score to assess the healing of humeral shaft fractures, the Radiographic Union Score for HUmeral fractures (RUSHU). The secondary aim was to assess whether the six-week RUSHU was predictive of nonunion at six months after the injury.

Patients and Methods

Initially, 20 patients with radiographs six weeks following a humeral shaft fracture were selected at random from a trauma database and scored by three observers, based on the Radiographic Union Scale for Tibial fractures system. After refinement of the RUSHU criteria, a second group of 60 patients with radiographs six weeks after injury, 40 with fractures that united and 20 with fractures that developed nonunion, were scored by two blinded observers.

Results

After refinement, the interobserver intraclass correlation coefficient (ICC) was 0.79 (95% confidence interval (CI) 0.67 to 0.87), indicating substantial agreement. At six weeks after injury, patients whose fractures united had a significantly higher median score than those who developed nonunion (10 vs 7; p < 0.001). A receiver operating characteristic curve determined that a RUSHU cut-off of < 8 was predictive of nonunion (area under the curve = 0.84, 95% CI 0.74 to 0.94). The sensitivity was 75% and specificity 80% with a positive predictive value (PPV) of 65% and a negative predictive value of 86%. Patients with a RUSHU < 8 (n = 23) were more likely to develop nonunion than those with a RUSHU ≥ 8 (n = 37, odds ratio 12.0, 95% CI 3.4 to 42.9). Based on a PPV of 65%, if all patients with a RUSHU < 8 underwent fixation, the number of procedures needed to avoid one nonunion would be 1.5.

Conclusion

The RUSHU is reliable and effective in identifying patients at risk of nonunion of a humeral shaft fracture at six weeks after injury. This tool requires external validation but could potentially reduce the morbidity associated with delayed treatment of an established nonunion. Cite this article: Bone Joint J 2019;101-B:1300–1306
Educando para o desenvolvimento sustentável por meio da interdisciplinaridade: contribuições da aprendizagem experiencial no ensino de gestão
Authors: Trindade Nathália Rigui , Trevisan Marcelo , Lima Érica Santini de , Favarin Rodrigo Reis
Published: September 2019

Cessar a reprodução dos atuais problemas sociais, ambientais e econômicos exige uma transformação da maneira de abordar a educação e a vida, o que evidencia a importância da Educação para a Sustentabilidade (EpS). Ao analisar a formação de profissionais de gestão, a importância da EpS fica ainda mais manifesta, considerando os impactos das decisões destes profissionais sobre o meio ambiente e sociedade.  Assim, para que objetivos da EpS sejam alcançados, novas propostas pedagógicas são necessárias, a EpS encontra oportunidades nas abordagens de aprendizagem de epistemologia construtivista, como a Aprendizagem Experiencial (AE). Assim, a presente pesquisa tem como objetivo analisar a capacidade contributiva da Aprendizagem Experiencial para a Educação para a sustentabilidade em uma iniciativa interdisciplinar desenvolvida no ensino de gestão. A partir da realização de entrevistas e aplicação de questionário, levantou-se dados a respeito de iniciativa interdisciplinar, composta por duas disciplinas (Projeto Interdisciplinar 1 e 2) e sua relação com a AE. Os resultados indicam que ao adotar a AE como pano de fundo para o desenvolvimento da iniciativa é possível alcançar os resultados almejados pela EpS, podendo contribuir com o desenvolvimento discente no que tange ao pensamento crítico, visão sistêmica, perspectiva de futuro, entre outros.
Strategies for globally responsible education management: a Brazilian case study on executive education
Authors: Arruda Filho Norman de Paula , Hino Marcia Regina Martelozo Cassitas , Beuter Barbara S. Przybylowicz
Published: September 2019

The aim of responsible management education is to build students' capacities to be future sustainable value generators for business and society in general. In this sense, business schools need to promote a sustainable management vision associated with the student’s scope of study. Based on this alignment, this research aims to analyze the effectiveness of a sustainability training discipline created by ISAE Brazilian Business School in raising awareness and promoting sustainable management reflection for executive students from different areas of knowledge. Based on the answer of students on questionnaires applied before and after each class, this analyze looks for measure the level of knowledge acquired by the participants, reflecting about this kind of initiative social contribution. The findings demonstrate a significant growth curve in the learning process representing a positive impact that allows researchers infers “Seminar of Contextualization” has an important contribution to raise awareness among leaders in search of a more sustainable world.
Objetivos do Desenvolvimento Sustentável e educação para a sustentabilidade: análise das concepções de sustentabilidade de estudantes de Administração em uma instituição superior pública
Authors: Farias Luciana Cabral , Coelho Ana Lúcia de Araújo Lima , Coelho Christiano
Published: September 2019

Esta pesquisa teve por objetivo identificar, por meio da análise das concepções de sustentabilidade dos estudantes do curso de Administração da UFPB, maneiras de se incorporar a sustentabilidade à sua formação. Em termos metodológicos, realizou-se uma pesquisa fenomenográfica, abordagem cujo objetivo é investigar empiricamente como as pessoas experienciam, compreendem e atribuem significado a um fenômeno no mundo em torno deles. Sua aplicação na UFPB levou em conta a relevância de se estudar educação para a sustentabilidade em um campus universitário inserido em um ambiente de Mata Atlântica. Foram identificadas três concepções de sustentabilidade: oportunidade, recursos e senso de coletividade, da mais superficial à mais profunda, respectivamente. A pesquisa revelou que a maior parte dos estudantes entrevistados concebe sustentabilidade em termos de recursos, não sendo possível identificar um aprofundamento resultante do processo de formação desses estudantes. Cinco direcionamentos foram apontados pelos alunos para a incorporação da sustentabilidade na formação do administrador: a criação de uma disciplina específica focada na sustentabilidade; a abordagem da sustentabilidade de forma interdisciplinar; a prática como aporte à teoria; o fomento a projetos de iniciação científica que tratem sobre essa temática; e a realização de campanhas institucionais de conscientização sobre a sustentabilidade.
Proof of prevention
Authors: Turner Chris
Published: September 2019

How to ensure patients are equipped with the necessary information and tools to manage their oral health.
PRINCÍPIOS E FATORES MOTIVADORES PARA ADOÇÃO DAS GOVERNANÇAS CORPORATIVA DE TI E DA INFORMAÇÃO
Authors: Maçada Antonio Carlos Gastaud , Brinkhues Rafael Alfonso , Freitas Jr. José Carlos Da Silva , Lajara Tamara Tebaldi
Published: September 2019

Essa pesquisa se propõe a analisar os princípios e os fatores motivadores para adoção da governança corporativa, da tecnologia da informação (TI) e da Governança da Informação (GI). Fundamentado na Economia da Informação e na Teoria da Agência, foi realizada a identificação na literatura dos princípios e dos fatores motivadores desses três tipos de governança. Por meio de um estudo de casos múltiplos em três organizações que adotam estruturas de governança corporativa, da TI e da Informação, foi possível analisar esses elementos a partir da perspectiva dos executivos das respectivas áreas das empresas. Com base nos resultados da pesquisa, foi possível realizar um comparativo entre as estruturas de governança dos três casos. Os resultados demonstram que não há uma estrutura ideal para governança, cada caso possui relações únicas, sendo que os casos não apresentaram consenso na relação entre governança de TI e da Informação. O estudo revela que há uma falta de consenso em relação a dois tipos de governança analisados, TI e GI, bem como identifica uma negligência em relação aos fatores contingenciais que afetam o ambiente informacional, contribuindo, assim, para o desenvolvimento da literatura, especialmente de GI, ainda incipiente na pesquisa acadêmica. Para os praticantes, a pesquisa contribui com a comparação e a análise das estruturas de governança, que os auxilia a definirem os elementos mais adequados para cada organização.
CENTRALIDADE E DENSIDADE EM UMA REDE DE LOGÍSTICA REVERSA DE EMBALAGENS DE DEFENSIVOS AGRÍCOLAS
Authors: Santos Caroline Coradassi Almeida , Castro Marcos De , Lima Luciano Ferreira de
Published: September 2019

O artigo buscou compreender a relação entre os atores e a formação de rede na cadeia reversa das embalagens de defensivos agrícolas na região centro-sul do Estado do Paraná. Por se tratar de um estudo de caso, tomou como referência a Associação dos Distribuidores de Defensivos Agrícolas do Centro-Sul (ADDCS), que é corresponsável pela captação de embalagens e pela destinação correta, juntamente com o Instituto Nacional de Processamento de Embalagens Vazias (INPEV). A escolha metodológica para a realização do estudo possui uma abordagem qualitativa com suporte quantitativo. Assim, para a coleta de dados em campo foram realizadas entrevistas estruturadas com base em um roteiro de avaliação sociométrica e entrevistas semiestruturadas com os principais atores relacionados à organização foco do estudo. Os resultados apontaram que há uma relação interorganizacional, mas os resultados apontam ainda uma rede com características difusas, ou seja, atores com pouco contato podem ser fatores que ainda venham a restringir o alcance de melhores resultados, sendo que muitas vezes as ações dos agentes são induzidas por possíveis sanções que possam sofrer em virtude da lei.
Nanocrystalline Nickel Electrodeposition on Carbon Steel Using Eco-Friendly Aqueous Ananas comosus Juice
Authors: Florence J. Felicita , Lavanya M. , Joice J. Amala Infant , Thabassoom H. Asia , Kanmani R.
Published: September 2019

The present study aims to investigate the effect of Ananas comosus juice on nickel electrodeposition on mild steel. The effect of this additive on electrodeposition behaviour, bath composition, surface morphology and corrosion performance of the nickel electrodeposited mild steel were investigated. The bath constitutents are optimized through Hull cell experiments. To investigate the nature of the deposits, FT-IR, scanning electron microscopy, EDAX, XRD and electrochemical methods are applied. Current efficiency and polarization studies were carried out. The results confirmed the influence of
Ananas comosus juice on nickel electrodeposition.
Extraction, Radical Scavenging and Antimicrobial Activity of
Essential Oils of Root of Dryopteris marginalis
Authors: Islam Md. Zahidul , Foisal Jannat Al , Rahman Mahbubur , Mimi Mst. Afsana , Islam Faridul , Habib Rasel , Khan Nowshin Farzana , Rahman Md. Atiqur , Parvin Tanzima , Cui Daxiang
Published: September 2019

The aim of the study was to characterize the chemical constituents and determine antibacterial and antioxidant activities of essential oils and three different extracts of Dryopteris marginalis. The root had essential oil yield of 0.36 % (w/w) in which 12 organic compounds representing 97.22% of the root oils were identified. Tyranton was found as the most abundant component with 77.571 % of the total concentration in the essential oil. The zones of inhibition of different organic extracts against the tested bacteria were found in the range of 6.5-15 mm. Pseudomonas was the most vulnerable with MICs of 15.62 μg/mL by both ethyl acetate and petroleum ether extract producing 3.8 mm zone of inhibition. The essential oils extracted from roots of Dryopteris marginalis showed maximum 85.29 % inhibition of radical scavenging at 2 mg/mL concentration. Among all root extracts, methanol extract exhibited 41.11 % inhibition at 2 mg/mL concentration.
Quantification of Prochlorperazine and Paracetamol Using High Performance
Liquid Chromatography: Application to Tablets and Stability Studies
Authors: Jagadeesh Kadali , Annapurna Nowduri
Published: September 2019

This study reports a new stability indicating HPLC method using Spursil C18 column as stationary phase, and mixture of 0.1 M Na2HPO4 and methanol (50:50 v/v) as mobile phase for the chromatographic determination of paracetamol and prochlorperazine in tablets and in bulk form. The linearity range is 250-750 μg/mL for paracetamol and 2.5-7.5 μg/mL for prochlorperazine. The limit of detection values are 2.650 μg/mL for paracetamol and 0.175 μg/mL for prochlorperazine. The minor values of the relative standard deviation (≤ 2.0 %) as well as good percent assay values (nearer to 100 %) confirm the high precision and accuracy of the present method. From the degradation study chromatograms found that there was no interference from degradants when paracetamol and prochlorperazine are quantified in tablets through the proposed method. A good agreement between results obtained and labeled claim for the determination of paracetamol and prochlorperazine in tablet samples demonstrates
that the proposed method is appropriate to quantify paracetamol and prochlorperazine in tablet formulations.
Synthesis and Characterization of Molecularly Imprinted Polymer for the
Removal/Extraction of Thymol from Spiked Blood Serum and River water
Authors: Bakhtiar Salma , Bhawani Showkat Ahmad , Shafqat Syed Rizwan
Published: September 2019

Molecularly imprinted polymers (MIPs) were prepared by precipitation polymerization using thymol as a template molecule, acrylamide as a functional monomer and N,N-methylbisacrylamide as the crosslinker with a non-covalent approach. The polymers were characterized by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), fourier-transform infra red spectroscopy(FT-IR) and Brunauer-Emmett-Teller (BET). The SEM results depicted that the shape of polymer particles is spherical with uniform size (micro-meters). The BET results also showed better surface area, pore size and pore volume of MIP as compared to non-imprinted polymer (NIP). A series of parameters such as initial concentration, polymer dosage, effect of pH and slectivity with structural analogue were conducted. The selectivity of MIP towards thymol was appreciable as compared to its structural analogue gallic acid with a relative selectivity coefficient of 3.59. Finally, MIP has been successfully used for extraction of thymol from the spiked blood serum (84 %) and river water sample (98 %).
Synthesis, Molecular Docking, Cytotoxicity and Antioxidant Activity Evaluation of Isoindoline-1,3-dione Derivatives
Authors: Kumar Palanichamy Santhosh , Kumar Kuruba Bharath , Obadiah Asir , Kumar Suluvoy Jagadish , Mohanapriya Raman , Durairaj Arulappan , Ramanathan Subramanian , Vasanthkumar Samuel
Published: September 2019

A variety of amines have been employed to functionalize isobenzofuran-1,3-dione to obtain isoindoline-1,3-dione derivatives in the base free conditions. All the synthesized compounds are screened for their bioactivity through molecular docking, cytotoxicity (against HeLa) and antioxidant activity. ABTS and DPPH are employed to assess the antioxidant activity. Among the synthesized isoindoline-1,3-dione derivatives (3a-k), compound 3e has showed the best antioxidant activity and also exhibited better binding energy when docked with caspase-3 protein. Cytotoxicity of the synthesized compounds was studied against cervical cancer cell line (HeLa) and compound 3e has displayed better activity than other isoindoline derivatives.
Progressive Two-Stage Efficient Codigestion of Food Waste and
Petrochemical Wastewater for Higher Methane and Hydrogen Production
Authors: Siddique M.N.I. , Zaied B.K. , Kabir M.N. , Ahmad M.F.
Published: September 2019

The valorization of agro-modern waste through anaerobic codigestion signifies a remarkable prospect for waste treatment and sustainable energy source generation. This study intended to improve the codigestion of food waste and petrochemical wastewater by an advanced two-phase process. In view of concentric acidogenic and methanogenic stages, intended for upgrading execution and diminishing pollution. The ideal food waste to petrochemical wastewater proportion was assessed under batch operations. From that point, codigestion was carried out by continuous feeding operations weighting single-and two-phase digestions. The outcomes exhibited that the supplementation of petrochemical wastewater in codigestion with food waste incredibly improved the anaerobic system. The maximum methane generation was acquired codigesting the two wastes at equivalent proportion by utilizing the creative two-phase system. The proposed framework achieved the highest methane production of 259 mL/g volatile solid, which is more than double than the single-phase system and 11 % greater than that of conventional two-phase system.