bluuebunny/crossref_metadata_2025 huggingface dataset:
Understanding the Perspectives and Experiences of Employed Older People on Active Ageing in Their Later Working Life (Biographical Narrative Approach)
Authors: You Yong-Lim , Lee Hyun-Suk
Published: June 2021

This thesis aims to understand the perspectives and experiences of older people regarding the concept of active ageing in their later working life with biographical narratives. This research adopted a biographical narrative interview for data collection. A total of 15 employed older people were interviewed by the researcher. The collected data were analysed using the biographical narrative analysis of Schütze (1983). The research findings are the following: in the first theme, the driving force to enable older people to choose active ageing in the workplace was their confidence in their work ability to include a challenging attitude at work. In the second theme, another driving force to enable older people to participate in economic activity that was considered was the individual workability of active older workers, including health rather than their chronological ageing in the labour market. However, in the third theme, research participants believed that the barrier of active ageing is a negative social prejudice on the working ability of older people. From this point of view, the research participants suggested that negative social prejudice for older workers should be overcome by active ageing experiences in age-friendly working environments as the fourth theme.
Erratum: Leino-Arjas et al. Process of Work Disability: From Determinants of Sickness Absence Trajectories to Disability Retirement in a Long-Term Follow-Up of Municipal Employees. Int. J. Environ. Res. Public Health 2021, 18, 2614
Authors: Leino-Arjas Päivi , Seitsamo Jorma , Nygård Clas-Håkan , K.C. Prakash , Neupane Subas
Published: June 2021

The authors wish to make the following correction to this paper [...]
Crossing Countries and Crossing Ages: The Difficult Transition to Adulthood of Unaccompanied Migrant Care Leavers
Authors: Gullo Federica , García-Alba Laura , Bravo Amaia , del Valle Jorge F.
Published: June 2021

The social changes experienced in many countries have prolonged the transition to adult life for young people. That being said, those who leave child care cannot afford this privilege, in that they do not benefit from the same support and resources, having to confront an accelerated transition which exposes them to increased risk of negative outcomes and social exclusion. Moreover, this transition might be even riskier for unaccompanied migrant care leavers, who are four times as vulnerable, given their status as young people in care, as adolescents, as migrants and being unaccompanied. This paper seeks to explore the profiles, needs, and experiences of unaccompanied young migrants in comparison with other care leavers. Data were collected by means of a semi-structured interview to explore their pre-care, in-care, and aftercare experiences. A highly specific profile of unaccompanied young migrants has been revealed that differs from the other care leavers in terms of worse educational, occupational, and economic outcomes, limited support networks, and more obstacles to accessing aftercare supports. Conversely, they also exhibited some strengths, such as having less pre-care, in care, and aftercare traumatic experiences, less psychological distress and fewer risky behaviors compared with other care leavers.
Psychological Support Interventions for Healthcare Providers and Informal Caregivers during the COVID-19 Pandemic: A Systematic Review of the Literature
Authors: Bertuzzi Vanessa , Semonella Michelle , Bruno Denise , Manna Chiara , Edbrook-Childs Julian , Giusti Emanuele M. , Castelnuovo Gianluca , Pietrabissa Giada
Published: June 2021

Background: During the COVID-19 pandemic, healthcare providers and informal caregivers were at an increased risk of adverse mental health effects. This systematic review provides a summary of the available evidence on the content and efficacy of the psychological support interventions in increasing mental health among healthcare providers and informal caregivers during the COVID-19 pandemic. Methods: PubMed, Google Scholar, PsychINFO, and Scopus databases were systematically searched for relevant articles, and the methodological quality of selected articles was assessed using the Quality Assessment Tool for Quantitative Studies. Results: A search of electronic databases identified five reports based on inclusion and exclusion criteria. All psychological support interventions for caregivers were delivered digitally. Despite the large heterogeneity of the selected studies, the findings support the efficacy of mental health interventions in reducing distress and burnout, while promoting self-efficacy and well-being in both healthcare providers and informal caregivers. Conclusion: Since mental health problems are expected to increase during, and as a result of, the COVID-19 pandemic, and digital tools might offer a range of mental health treatments to meet the unique and immediate needs of people, further research is needed to test the cost-effectiveness of digital psychological interventions.
Biomarkers for Homologous Recombination Deficiency in Cancer
Authors: Wagener-Ryczek Svenja , Merkelbach-Bruse Sabine , Siemanowski Janna
Published: June 2021

DNA double-strand breaks foster tumorigenesis and cell death. Two distinct mechanisms can be activated by the cell for DNA repair: the accurate mechanism of homologous recombination repair or the error-prone non-homologous end joining. Homologous Recombination Deficiency (HRD) is associated with sensitivity towards PARP inhibitors (PARPi) and its determination is used as a biomarker for therapy decision making. Nevertheless, the biology of HRD is rather complex and the application, as well as the benefit of the different HRD biomarker assays, is controversial. Acquiring knowledge of the underlying molecular mechanisms is the main prerequisite for integration of new biomarker tests. This study presents an overview of the major DNA repair mechanisms and defines the concepts of HRR, HRD and BRCAness. Moreover, currently available biomarker assays are described and discussed with respect to their application for routine clinical diagnostics. Since patient stratification for efficient PARP inhibitor therapy requires determination of the BRCA mutation status and genomic instability, both should be established comprehensively. For this purpose, a broad spectrum of distinct assays to determine such combined HRD scores is already available. Nevertheless, all tests require careful validation using clinical samples to meet the criteria for their establishment in clinical testing.
Between Impunity and Imperialism: The Regulation of Transnational Bribery
Authors: ‘Arafa Mohamed A.
Published: June 2021

The Regulation of Transnational Bribery by Kevin E. Davis, strips out the universal character of illegitimate payments used to bribe public officials of foreign countries in the milieu of international business which has been known for years. The manuscript deals with various definitions of bribery as a transaction in which an official misuse his or her office “as a result of considerations of personal gain, which need not be monetary”. The book highlights the current debate about prohibiting transnational bribery. Such a debate is not about the practicality or desirability of the United States’ FCPA, which at one time was the only law in the world that efficiently banned transnational bribery.
Electrochemically Activated Screen-Printed Carbon Sensor Modified with Anionic Surfactant (aSPCE/SDS) for Simultaneous Determination of Paracetamol, Diclofenac and Tramadol
Authors: Kozak Jędrzej , Tyszczuk-Rotko Katarzyna , Wójciak Magdalena , Sowa Ireneusz
Published: June 2021

In this work, an electrochemically activated screen-printed carbon electrode modified with sodium dodecyl sulfate (aSPCE/SDS) was proposed for the simultaneous determination of paracetamol (PA), diclofenac (DF), and tramadol (TR). Changes of surface morphology and electrochemical behaviour of the electrode after the electrochemical activation with H2O2 and SDS surface modification were studied by scanning electron microscopy (SEM), cyclic voltammetry (CV), and electrochemical impedance spectroscopy (EIS). The influence of various parameters on the responses of the aSPCE/SDS such as pH and concentration of the buffer, SDS concentration, and techniques parameters were investigated. Using optimised conditions (Eacc. of −0.4 V, tacc. of 120 s, ΔEA of 150 mV, ν of 250 mV s−1, and tm of 10 ms), the aSPCE/SDS showed a good linear response in the concentration ranges of 5.0 × 10−8–2.0 × 10−5 for PA, 1.0 × 10−9–2.0 × 10−7 for DF, and 1.0 × 10−8–2.0 × 10−7 and 2.0 × 10−7–2.0 × 10−6 mol L−1 for TR. The limits of detection obtained during the simultaneous determination of PA, DF, and TR are 1.49 × 10−8 mol L−1, 2.10 × 10−10 mol L−1, and 1.71 × 10−9 mol L−1, respectively. The selectivity of the aSPCE/SDS was evaluated by examination of the impact of some inorganic and organic substances that are commonly present in environmental and biological samples on the responses of PA, DF, and TR. Finally, the differential pulse adsorptive stripping voltammetric (DPAdSV) procedure using the aSPCE/SDS was successfully applied for the determination of PA, DF, and TR in river water and serum samples as well as pharmaceuticals.
Comprehensive Analysis of Steel Slag as Aggregate for Road Construction: Experimental Testing and Environmental Impact Assessment
Authors: Díaz-Piloneta Marina , Terrados-Cristos Marta , Álvarez-Cabal Jose Valeriano , Vergara-González Eliseo
Published: June 2021

Blast Oxygen Furnace (BOF) slag represents one of the largest waste fractions from steelmaking. Therefore, slag valorisation technologies are of high importance regarding the use of slag as a secondary resource, both in the steel sector and in other sectors, such as the construction or cement industries. The main issue regarding the use of BOF slag is its volumetric instability in the presence of water; this hampers its use in sectors and requires a stabilisation pre-treatment. These treatments are also cost-inefficient and cause other environmental issues. This paper analyses the use of untreated BOF slag from a technical and environmental point of view, suggesting it as an alternative to natural aggregates in road surface layers and asphalt pavements. A comprehensive analysis of the requirements to be met by raw materials used in asphalt mixes was performed, and a pilot test was carried out with two different mixtures: one mix with limestone as coarse aggregate and another with 15% BOF slag. Furthermore, the global warming impacts derived from each mix with different aggregates were measured by Life Cycle Analysis (LCA), and a transport sensitivity analysis was also performed. The results show how the utilization of BOF slag as coarse aggregate in road construction improves the technical performance of asphalt mixtures (Marshall Quotient 4.9 vs. 6.6). Moreover, the introduction of BOF slag into the asphalt mix as a coarse aggregate, instead of limestone, causes a carbon emissions reduction rate of more than 14%.
Enhancement of Magnetic and Tensile Mechanical Performances in Fe-Based Metallic Microwires Induced by Trace Ni-Doping
Authors: Zhang Mingwei , Qu Guanda , Liu Jingshun , Pang Mengyao , Wang Xufeng , Liu Rui , Cao Guanyu , Ma Guoxi
Published: June 2021

Herein, the effect of Ni-doping amount on microstructure, magnetic and mechanical properties of Fe-based metallic microwires was systematically investigated further to reveal the influence mechanism of Ni-doping on the microstructure and properties of metallic microwires. Experimental results indicate that the rotated-dipping Fe-based microwires structure is an amorphous and nanocrystalline biphasic structure; the wire surface is smooth, uniform and continuous, without obvious macro- and micro-defects that have favorable thermal stability; and moreover, the degree of wire structure order increases with an increase in Ni-doping amount. Meanwhile, FeSiBNi2 microwires possess the better softly magnetic properties than the other wires with different Ni-doping, and their main magnetic performance indexes of Ms, Mr, Hc and μm are 174.06 emu/g, 10.82 emu/g, 33.08 Oe and 0.43, respectively. Appropriate Ni-doping amount can effectively improve the tensile strength of Fe-based microwires, and the tensile strength of FeSiBNi3 microwires is the largest of all, reaching 2518 MPa. Weibull statistical analysis also indicates that the fracture reliability of FeSiBNi2 microwires is much better and its fracture threshold value σu is 1488 MPa. However, Fe-based microwires on macroscopic exhibit the brittle fracture feature, and the angle of sideview fracture θ decreases as Ni-doping amount increases, which also reveals the certain plasticity due to a certain amount of nanocrystalline in the microwires structure, also including a huge amount of shear bands in the sideview fracture and a few molten drops in the cross-section fracture. Therefore, Ni-doped Fe-based metallic microwires can be used as the functional integrated materials in practical engineering application as for their unique magnetic and mechanical performances.
Influence of the Precursor, Molarity and Temperature on the Rheology and Structural Buildup of Alkali-Activated Materials
Authors: Siddique Salman , Gupta Vivek , Chaudhary Sandeep , Park Solmoi , Jang Jeong-Gook
Published: June 2021

This study presents an investigation of the effects of the precursor, alkalinity and temperature on the rheology and structural buildup of alkali activated materials. Here, 100% fly ash, 100% slag and blended mixes of fly ash and slag were activated by 4 M, 6 M, 8 M or 10 M (only for sodium hydroxide) solutions at 25 °C, 35 °C, 45 °C and 55 °C. The rheological properties were investigated to obtain the flow curves, viscosity, storage modulus, and loss factor of these materials. The results showed that for the presence of slag, a higher molarity of the alkali activating solution and a high temperature all caused greater interparticle force, leading to an increase in the shear stress and viscosity of the alkali activated materials. It was also observed that slag had the greatest effect on the increase in the storage modulus of the blended mixes. Furthermore, the higher alkalinity and temperature levels were instrumental in initiating the dissolution of fly ash and improving its rate of structural buildup. Moreover, the interdependence of various factors showed that the type of precursor, as well as the concentration of alkali activating solution, were the primary influencing factors on the polymerization process, as well as the rheological measurements of alkali-activated materials.
Selective Adsorption of Potassium in Seawater by CoHCF Thin Film Electrode and Its Electrochemical Desorption/Regeneration
Authors: Zhang Nan , Kawamoto Tohru , Watanabe Hiroshi , Jiang Yong , Zhang Zhenya , Lei Zhongfang , Parajuli Durga
Published: June 2021

Cobalt Hexacyanoferrate (CoHCF) was tested for the selective uptake of K from seawater and the electrochemical method was adopted for the desorption and regeneration of the material. Powder form CoHCF could adsorb about 6.5 mmol/g of K from the seawater. For the ease of the electrochemical desorption and regeneration, CoHCF thin film was coated onto the Indium Tin Oxide (ITO) glass to obtain a CoHCF electrode. K adsorption kinetics on CoHCF thin film was found to be well fitted with the intraparticle diffusion model, which was a two-step process. Five consecutive adsorption-desorption-regeneration cycles were carried out to know the gradual decrease in the adsorption capacity owing to changes in the redox states of two metals, Co and Fe, in the material. Fourier Transform Infrared Spectroscopy (FT-IR) and Ultraviolet-Visible (UV-Vis) measurement results corresponded to the color change of CoHCF thin film, indicating the valence change of transition metals and the exchange of alkali metal cations happened on the CoHCF at different operation stages. In order to elucidate the reaction mechanism, composition of the material was analysis in the following steps: adsorption, desorption, and regeneration. It was proved that the system based on CoHCF thin film modified electrode had the potential of recovering potassium from seawater.
Influence of Amorphous Boron Grain Size, High Isostatic Pressure, Annealing Temperature, and Filling Density of Unreacted Material on Structure, Critical Parameters, n-Value, and Engineering Critical Current Density in MgB2 Wires
Authors: Gajda Daniel , Zaleski Andrzej J. , Morawski Andrzej , Małecka Małgorzata , Akdoğan Mustafa , Karaboğa Firat , Avcı Doğan , Yetiş Hakan , Belenli Ibrahim , Czujko Tomasz
Published: June 2021

Our results show that a lower density of unreacted Mg + B material during an Mg solid-state synthesis reaction leads to a significant reduction in the quantity of the superconducting phase and lowers the homogeneity of the superconducting material. It also significantly reduces the irreversible magnetic field (Birr), critical temperature (Tc), upper magnetic field (Bc2), engineered critical current density (Jec), and n-value, despite high isostatic pressure (HIP) treatment and the use of nanoboron in the sample. Our measurements show that samples with large boron grains with an 8% higher density of unreacted Mg + B material allow better critical parameters to be achieved. Studies have shown that the density of unreacted material has little effect on Birr, Tc, Bc2, Jec, and the n-value for an Mg liquid-state synthesis reaction. The results show that the critical parameters during an Mg liquid-state synthesis reaction depend mainly on grain size. Nanoboron grains allow for the highest Birr, Tc, Bc2, Jec, and n-values. Scanning electron microscopy (SEM) images taken from the longitudinal sections of the wires show that the samples annealed under low isostatic pressure have a highly heterogeneous structure. High isostatic pressure heat treatment greatly improves the homogeneity of MgB2.
Experimental Study of the Mechanical and Microstructure Characteristics of Coal Gangue Road Stabilization Materials Based on Alkali Slag Cementation
Authors: Wang Changbai , Yang Junxin , Xu Shuzhan
Published: June 2021

To accelerate the resource utilization of coal gangue and meet the strategic requirements of carbon neutralization, alkali-activated, slag-cemented coal gangue is applied in the preparation of solid waste-based road stabilization materials. Here, the cementation characteristics and microstructure characteristics of alkali-activated, slag-cemented coal gangue road stabilization materials are studied using the alkali equivalent and coal gangue aggregate ratio as experimental variables. The results show that with the increase in alkali equivalent from 1% to 7%, the unconfined compressive strength of the alkali-activated coal gangue road stabilization material initially increases and then decreases, with 3% being the optimal group in terms of stabilization, the aggregate ratio of coal gangue increases from 70% to 85%, and the 7-day unconfined compressive strength of the stabilized material decreases approximately linearly from 8.16 to 1.68 MPa. At the same time, the porosity gradually increases but still meets the requirements of the specification. With the increase in hydration time, a large number of hydration products are formed in the alkali slag cementation system, and they are closely attached to the surface of and interweave with the coal gangue to fill the pores, resulting in the alkali slag slurry and coal gangue being brought closer together.
Cyclic Behavior of Reinforced High Strain-Hardening UHPC under Axial Tension
Authors: Gu Jin-Ben , Wang Jun-Yan , Guo Yi-Qing
Published: June 2021

The cyclic tensile behavior of steel-reinforced high strain-hardening ultrahigh-performance concrete (HSHUHPC) was investigated in this paper. In the experimental program, 12 HSHUHPC specimens concentrically placed in a single steel reinforcement under cyclic uniaxial tension were tested, accompanied by acoustic emission (AE) source locating technology, and 4 identical specimens under monotonic uniaxial tension were tested as references. The experimental variables mainly include the loading pattern, the diameter of the embedded steel rebar, and the level of target strain at each cycle. The tensile responses of the steel-reinforced HSHUHPC specimens were evaluated using multiple performance measures, including the failure pattern, load–strain response, residual strain, stiffness degradation, and the tension-stiffening behavior. The test results showed that the enhanced bond strength due to the inclusion of steel fibers transformed the failure pattern of the steel-reinforced HSHUHPC into a single, localized macro-crack in conjunction with a sprinkling of narrow and closely spaced micro-cracks, which intensified the strain concentration in the embedded steel rebar. Besides, it was observed that the larger the diameter of the embedded steel rebar, the smaller the maximum accumulative tensile strain under cyclic tension, which indicated that the larger the diameter of the embedded steel rebar, the greater the contribution to the tensile stiffness of steel-reinforced HSHUHPC specimens in the elastic–plastic stage. In addition, it was found that a larger embedded steel rebar appeared to reduce the tension-stiffening effect (peak tensile strength) of the HSHUHPC. Moreover, the residual strain and the stiffness of the steel-reinforced HSHUHPC were reduced by increasing the number of cycles and finally tended toward stability. Nevertheless, different target strain rates in each cycle resulted in different eventual cumulative tensile strain rates; hence the rules about failure pattern, residual strain, and loading stiffness were divergent. Finally, the relationship between the accumulative tensile strain and the loading stiffness degradation ratio under cyclic tension was proposed and the tension-stiffening effect was analyzed.
Analysis of Friction Stir Welding Tool Offset on the Bonding and Properties of Al–Mg–Si Alloy T-Joints
Authors: Memon Shabbir , Murillo-Marrodán Alberto , Lankarani Hamid M. , Aghajani Derazkola Hesamoddin
Published: June 2021

Research on T-configuration aluminum constructions effectively decreases fuel consumption, increases strength, and develops aerial structures. In this research, the effects of friction stir welding (FSW) tool offset (TO) on Al–Mg–Si alloy mixing and bonding in T-configurations is studied. The process is simulated by the computational fluid dynamic (CFD) technique to better understand the material mixing flow and the bonding between the skin and flange during FSW. According to the results, the best material flow can be only achieved at an appropriate TO. The appropriate TO generates enough material to fill the joint line and results in formation of the highest participation of the flange in the stir zone (SZ) area. The results show that, in the T-configuration, FSW joints provide raw materials from the retreating side (RS) of the flange that play a primary role in producing a sound mixing flow. The selected parameters were related to the geometric limitations of the raw sheets considered in this study. The failure point of all tensile samples was located on the flange. Surface tunneling is the primary defect in these joints, which is produced at high TOs. Among the analyzed cases, the most robust joint was made at +0.2 mm TO on the advancing side (AS), resulting in more than 60% strength of the base aluminum alloy being retained.
Preparation and Characterization of Mg–Al–B Alloy (Mg0.5Al0.5B2) Via High-Temperature Sintering
Authors: Yang Lin , He Jie , Ma Yusong , Zhang Liang , Ma Shizhou , Gai Xiqiang , Zhang Xinggao
Published: June 2021

Boron and its alloys have long been explored as potential fuel and increasingly replace pure aluminum powder in high-energy formulations. The ignition and burning properties of boron can be improved by making boron alloys. In this study, an Mg–Al–B alloy was synthesized from magnesium, aluminum and boron powders in a 1:1:4 molar ratio by preheating to 600 °C for 30 min, followed by high-temperature sintering in a tube furnace. The effects of sintering temperature (700–1000 °C) and holding time (0.5–10 h) on the phase composition of mixed powders were studied. After the samples were cooled to room temperature, they were ground into powder. The phase composition, micromorphology and the bonding forms of elements of the synthesized samples were studied using XRD, SEM and XPS. The results show that each element exists in the form of simple substance in the alloy. The influence of the sintering temperature on the synthesis reaction of Mg0.5Al0.5B2 is very important, but holding time has little effect on it. With the increase of sintering temperature, the content of the Mg0.5Al0.5B2 phase gradually increases, and the phase content of residual metal gradually decreases. The phase and morphology analyses show that the optimum sintering temperature is 1000 °C with a minimum holding time of 0.5 h. It is expected to be used in gunpowder, propellant, explosives and pyrotechnics with improved characteristics.
Effect of Aging Treatment on the Corrosion Resistance Properties of 7N01 Extrusion Aluminum Alloy
Authors: Li Yitai , Qin Weiou , Yu Shuyuan , La Jun , Fu Yaokun , Li Jidong , Yang Wenchao , Zhan Yongzhong
Published: June 2021

The influences of non-isothermal aging (the temperature range is 150–180 °C, and the heating rate is 5 and 20 °C/h alternately), single-peak aging (aging at 120 °C for 24 h, then water quenched was followed at room temperature), and two-stage aging (aging at 105 °C for 8 h first, then increasing aging temperature to 135 °C and keeping for 12 h, followed by water quenching at room temperature) on the corrosion resistance and microstructure of the 7N01 aluminum alloy under 3.5 wt.% NaCl were investigated using electric polarization curve test and exfoliation corrosion. After aging, the hardness of samples was measured by a Vickers micro-hardness tester, and the electrical conductivities were obtained using the eddy current method. The results show that the steady phase η and metastable phase η′ are precipitated in the grain boundary of 7N01 aluminum alloy after non-isothermal aging, and their distribution is discontinuous. The hardness of the alloy can reach 136.9 HV1 and the electrical conductivity can reach 35.8% IACS, which is close to the hardness of single-peak aging and the conductivity of two-stage aging, respectively. Compared with single-peak aging, the corrosion current density of non-isothermal aging is reduced by 15.5%, and that of two-stage aging is reduced by 28.9%.
Experimental Study on Compression Failure of Composite Laminates with Prefabricated Surface Cracks
Authors: Sun Wei , Ouyang Tian , Li Zengshan , Li Yan
Published: June 2021

A new compression test fixture was designed in the present work to study the damage tolerance of composite laminates with surface cracks or notches. The compression failure behaviors of CCF300/5228A quasi-isotropic composite laminates with prefabricated surface cracks were studied experimentally. Through the size design of the test fixture and specimens and an application of a simple test method, the complex crack growth process was captured. The experimental results showed that the compression failure modes were mainly affected by crack angles and depths, and there were two typical failure modes, which were local intra- and inter-laminar damage propagating from the crack tips and delamination growth induced from the crack leading edge. This study verified the validity of the test fixture and test method, and revealed the compression failure mechanisms of composite laminates with surface cracks.
Quadratic First Integrals of Time-Dependent Dynamical Systems of the Form q¨a=−Γbcaq˙bq˙c−ω(t)Qa(q)
Authors: Mitsopoulos Antonios , Tsamparlis Michael
Published: June 2021

We consider the time-dependent dynamical system q¨a=−Γbcaq˙bq˙c−ω(t)Qa(q) where ω(t) is a non-zero arbitrary function and the connection coefficients Γbca are computed from the kinetic metric (kinetic energy) of the system. In order to determine the quadratic first integrals (QFIs) I we assume that I=Kabq˙aq˙b+Kaq˙a+K where the unknown coefficients Kab,Ka,K are tensors depending on t,qa and impose the condition dIdt=0. This condition leads to a system of partial differential equations (PDEs) involving the quantities Kab,Ka,K,ω(t) and Qa(q). From these PDEs, it follows that Kab is a Killing tensor (KT) of the kinetic metric. We use the KT Kab in two ways: a. We assume a general polynomial form in t both for Kab and Ka; b. We express Kab in a basis of the KTs of order 2 of the kinetic metric assuming the coefficients to be functions of t. In both cases, this leads to a new system of PDEs whose solution requires that we specify either ω(t) or Qa(q). We consider first that ω(t) is a general polynomial in t and find that in this case the dynamical system admits two independent QFIs which we collect in a Theorem. Next, we specify the quantities Qa(q) to be the generalized time-dependent Kepler potential V=−ω(t)rν and determine the functions ω(t) for which QFIs are admitted. We extend the discussion to the non-linear differential equation x¨=−ω(t)xμ+ϕ(t)x˙(μ≠−1) and compute the relation between the coefficients ω(t),ϕ(t) so that QFIs are admitted. We apply the results to determine the QFIs of the generalized Lane–Emden equation.
A Scalable Bidimensional Randomization Scheme for TLC 3D NAND Flash Memories
Authors: Favalli Michele , Zambelli Cristian , Marelli Alessia , Micheloni Rino , Olivo Piero
Published: June 2021

Data randomization has been a widely adopted Flash Signal Processing technique for reducing or suppressing errors since the inception of mass storage platforms based on planar NAND Flash technology. However, the paradigm change represented by the 3D memory integration concept has complicated the randomization task due to the increased dimensions of the memory array, especially along the bitlines. In this work, we propose an easy to implement, cost effective, and fully scalable with memory dimensions, randomization scheme that guarantees optimal randomization along the wordline and the bitline dimensions. At the same time, we guarantee an upper bound on the maximum length of consecutive ones and zeros along the bitline to improve the memory reliability. Our method has been validated on commercial off-the-shelf TLC 3D NAND Flash memory with respect to the Raw Bit Error Rate metric extracted in different memory working conditions.
Designing an Ultrathin Film Spectrometer Based on III-Nitride Light-Absorbing Nanostructures
Authors: Kim Juhyeon , Cheekati Srinivasa , Sarwar Tuba , Ku Pei-Cheng
Published: June 2021

In this paper, a spectrometer design enabling an ultrathin form factor is proposed. Local strain engineering in group III-nitride semiconductor nanostructured light-absorbing elements enables the integration of a large number of photodetectors on the chip exhibiting different absorption cut-off wavelengths. The introduction of a simple cone-shaped back-reflector at the bottom side of the substrate enables a high light-harvesting efficiency design, which also improves the accuracy of spectral reconstruction. The cone-shaped back-reflector can be readily fabricated using mature patterned sapphire substrate processes. Our design was validated via numerical simulations with experimentally measured photodetector responsivities as the input. A light-harvesting efficiency as high as 60% was achieved with five InGaN/GaN multiple quantum wells for the visible wavelengths.
Integration of Ultra-Low Volume Pneumatic Microfluidics with a Three-Dimensional Electrode Network for On-Chip Biochemical Sensing
Authors: Tomar Saurabh , Lasne Charlotte , Barraud Sylvain , Ernst Thomas , Guiducci Carlotta
Published: June 2021

This paper reports a novel miniaturized pseudo reference electrode (RE) design for biasing Ion Sensitive Field Effect Transistors (ISFETs). It eliminates the need for post-CMOS processing and can scale up in numbers with the CMOS scaling. The presented design employs silane-mediated transfer of patterned gold electrode lines onto PDMS microfluidics such that the gold conformally coats the inside of microfluidic channel. Access to this electrode network is made possible by using “through-PDMS-vias” (TPV), which consist of high metal-coated SU-8 pillars manufactured by a novel process that employs a patterned positive resist layer as SU-8 adhesion depressor. When integrated with pneumatic valves, TPV and pseudo-RE network were able to bias 1.5 nanoliters (nL) of isolated electrolyte volumes. We present a detailed characterization of our pseudo-RE design demonstrating ISFET operation and its DC characterization. The stability of pseudo-RE is investigated by measuring open circuit potential (OCP) against a commercial Ag/AgCl reference electrode.
Dynamic Modeling and Flow Distribution of Complex Micron Scale Pipe Network
Authors: Zhao Yao , Zhang Kai , Guo Fengbei , Yang Mingyue
Published: June 2021

A fluid simulation calculation method of the microfluidic network is proposed as a means to achieve the flow distribution of the microfluidic network. This paper quantitatively analyzes the influence of flow distribution in microfluidic devices impacted by pressure variation in the pressure source and channel length. The flow distribution in microfluidic devices with three types of channel lengths under three different pressure conditions is studied and shows that the results obtained by the simulation calculation method on the basis of the fluid network are close to those given by the calculation method of the conventional electrical method. The simulation calculation method on the basis of the fluid network studied in this paper has computational reliability and can respond to the influence of microfluidic network length changes to the fluid system, which plays an active role in Lab-on-a-chip design and microchannel flow prediction.
Fussy Eating among Children and Their Parents: Associations in Parent-Child Dyads, in a Sample of Children with and without Neurodevelopmental Disorders
Authors: Thorsteinsdottir Sigrun , Olsen Annemarie , Olafsdottir Anna S.
Published: June 2021

Parents are important agents in shaping children’s eating habits. However, the associations between children’s and parents’ eating behaviors are complex and may be convoluted for various reasons, such as parenting feeding styles, stressful mealtimes, and children’s neurodevelopmental disorders (ND), such as Autism Spectrum Disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD). The purpose of this study was to analyze associations between parents and their children’s fussy eating, in a cross-sectional sample of children, with and without ND. Ninety-seven parents answered screening questionnaires prior to an intervention study. Associations were investigated using two-way ANOVAs and chi-square analyses. Overall, children with ND accepted fewer food items and consumed unhealthier foods more frequently than children without ND. Fussy eating parents had children who accepted fewer food items and consumed unhealthier foods more frequently than children whose parents were not fussy eaters. Interaction effects were not significant. A higher proportion of fussy eating parents, than non-fussy eating parents, had children who had difficulties with combined foods and hidden ingredients. The findings highlight the need for further investigation into the relationships between parents’ influence on their children’s eating behavior and food consumption, as well as possible reciprocal impacts.
3,4-Difluorobenzocurcumin Inhibits Vegfc-Vegfr3-Erk Signalling to Block Developmental Lymphangiogenesis in Zebrafish
Authors: Okuda Kazuhide S. , Ng Mei Fong , Ruslan Nur Faizah , Bower Neil I. , Song Dedrick Soon Seng , Chen Huijun , Baek Sungmin , Crosier Philip S. , Koltowska Katarzyna , Astin Jonathan W. , Tan Pei Jean , Hogan Benjamin M. , Patel Vyomesh
Published: June 2021

Lymphangiogenesis, the formation of new lymphatic vessels from pre-existing vasculature, plays critical roles in disease, including in cancer metastasis and chronic inflammation. Preclinical and recent clinical studies have now demonstrated therapeutic utility for several anti-lymphangiogenic agents, but optimal agents and efficacy in different settings remain to be determined. We tested the anti-lymphangiogenic property of 3,4-Difluorobenzocurcumin (CDF), which has previously been implicated as an anti-cancer agent, using zebrafish embryos and cultured vascular endothelial cells. We used transgenic zebrafish labelling the lymphatic system and found that CDF potently inhibits lymphangiogenesis during embryonic development. We also found that the parent compound, Curcumin, does not inhibit lymphangiogenesis. CDF blocked lymphatic and venous sprouting, and lymphatic migration in the head and trunk of the embryo. Mechanistically, CDF impaired VEGFC-VEGFR3-ERK signalling in vitro and in vivo. In an in vivo pathological model of Vegfc-overexpression, treatment with CDF rescued endothelial cell hyperplasia. CDF did not inhibit the kinase activity of VEGFR3 yet displayed more prolonged activity in vivo than previously reported kinase inhibitors. These findings warrant further assessment of CDF and its mode of action as a candidate for use in metastasis and diseases of aberrant lymphangiogenesis.
How to Obtain a High Quality ctDNA in Lymphoma Patients: Preanalytical Tips and Tricks
Authors: Bourbon Estelle , Alcazer Vincent , Cheli Estelle , Huet Sarah , Sujobert Pierre
Published: June 2021

The analysis of circulating tumor DNA (ctDNA) released by tumor cells holds great promise for patients with lymphoma, to refine the diagnostic procedure, clarify the prognosis, monitor the response to treatment, and detect relapses earlier. One of the main challenges of the coming years is to adapt techniques from highly specialized translational teams to routine laboratories as this requires a careful technical and clinical validation, and we have to achieve this as fast as possible to transform a promising biomarker into a routine analysis to have a direct consequence on patient care. Whatever the analytical technology used, the prerequisite is to obtain high yields of ctDNA of optimal quality. In this review, we propose a step-by-step description of the preanalytical process to obtain high-quality ctDNA, emphasizing the technical choices that need to be made and the experimental data that can support these choices.
Designing of Co0.5Ni0.5GaxFe2−xO4 (0.0 ≤ x ≤ 1.0) Microspheres via Hydrothermal Approach and Their Selective Inhibition on the Growth of Cancerous and Fungal Cells
Authors: Rehman Suriya , Almessiere Munirah A. , Al-Jameel Suhailah S. , Ali Uzma , Slimani Yassine , Tashkandi Nedaa , Al-Saleh Najat S. , Manikandan Ayyar , Khan Firdos Alam , Al-Suhaimi Ebtesam A. , Baykal Abdulhadi
Published: June 2021

The current study offers an efficient design of novel nanoparticle microspheres (MCs) using a hydrothermal approach. The Co0.5Ni0.5GaxFe2−xO4 (0.0 ≤ x ≤ 1.0) MCs were prepared by engineering the elements, such as cobalt (Co), nickel (Ni), iron (Fe), and gallium (Ga). There was a significant variation in MCs’ physical structure and surface morphology, which was evaluated using energy dispersive X-ray analysis (EDX), X-ray diffractometer (XRD), high-resolution transmission electron microscopy (HR-TEM), and scanning electron microscope (SEM). The anti-proliferative activity of MCs was examined by MTT assay and DAPI staining using human colorectal carcinoma cells (HCT-116), human cervical cancer cells (HeLa), and a non-cancerous cell line—human embryonic kidney cells (HEK-293). Post 72 h treatment, MCs caused a dose dependent inhibition of growth and proliferation of HCT-116 and HeLa cells. Conversely, no cytotoxic effect was observed on HEK-293 cells. The anti-fungal action was assessed by the colony forming units (CFU) technique and SEM, resulting in the survival rate of Candida albicans as 20%, with severe morphogenesis, on treatment with MCs x = 1.0. These findings suggest that newly engineered microspheres have the potential for pharmaceutical importance, in terms of infectious diseases and anti-cancer therapy.
Electrospun Nanofibers/Nanofibrous Scaffolds Loaded with Silver Nanoparticles as Effective Antibacterial Wound Dressing Materials
Authors: Alven Sibusiso , Buyana Buhle , Feketshane Zizo , Aderibigbe Blessing Atim
Published: June 2021

The treatment of wounds is expensive and challenging. Most of the available wound dressings are not effective and suffer from limitations such as poor antimicrobial activity, toxicity, inability to provide suitable moisture to the wound and poor mechanical performance. The use of inappropriate wound dressings can result in a delayed wound healing process. Nanosize range scaffolds have triggered great attention because of their attractive properties, which include their capability to deliver bioactive agents, high surface area, improved mechanical properties, mimic the extracellular matrix (ECM), and high porosity. Nanofibrous materials can be further encapsulated/loaded with metal-based nanoparticles to enhance their therapeutic outcomes in wound healing applications. The widely studied metal-based nanoparticles, silver nanoparticles exhibit good properties such as outstanding antibacterial activity, display antioxidant, and anti-inflammatory properties, support cell growth, making it an essential bioactive agent in wound dressings. This review article reports the biological (in vivo and in vitro) and mechanical outcomes of nanofibrous scaffolds loaded with silver nanoparticles on wound healing.
Nanofibrous Formulation of Cyclodextrin Stabilized Lipases for Efficient Pancreatin Replacement Therapies
Authors: Tóth Gergő Dániel , Kazsoki Adrienn , Gyarmati Benjámin , Szilágyi András , Vasvári Gábor , Katona Gábor , Szente Lajos , Zelkó Romána , Poppe László , Balogh-Weiser Diána , Balogh György T.
Published: June 2021

Enzyme replacement therapies (ERT) have been of great help over the past 30 years in the treatment of various lysosomal storage disorders, including chronic pancreatitis and its common complication, exocrine pancreatic insufficiency. Research shows that difficulties in designing such drugs can be overcome by using appropriate additives and various enzyme immobilization techniques. Cyclodextrins (CDs) can be considered as a promising additive for enzyme replacement therapies, as they are known to enhance the activity of enzymes in a complex process due to their specific binding. In this study, we investigated the formulation of lipases (from Aspergillus oryzae and Burkholderia cepacia) paired with different cyclodextrins in poly(vinyl alcohol) (PVA) nanofibers by electrospinning technique. We examined the effect of the presence of cyclodextrins and nanoformulation on the lipase activity. The rheological and morphological characterizations of precursors and nanofibers were also performed using a viscometer as well as electron and Raman microscope. We found that by selecting the appropriate CD:lipase ratio, the activity of the investigated enzyme could be multiplied, and cyclodextrins can support the homogeneous dispersion of lipases inside the solid formula. In addition, the entrapment of lipases in PVA nanofibers led to a significant increase in activity compared to the preformulated precursor. In this way, the nanofibrous formulation of lipases combining CDs as additives can provide an efficient and sustainable possibility for designing novel solid medicines in ERT.
Short Onset and Enhanced Analgesia Following Nasal Administration of Non-Controlled Drugs in Nanovesicular Systems
Authors: Touitou Elka , Natsheh Hiba , Boukeileh Shatha , Awad Rania
Published: June 2021

Nasal nanovesicular delivery systems (NVS) containing the noncontrolled analgesic drugs Ketoprofen, Butorphanol or Tramadol, incorporated in a phospholipid nanovesicular carrier, were designed and investigated. The systems were first characterized for their physicochemical properties. Due to their composition, comprising propylene glycol as a lipid bilayers fluidizer, these systems contain soft vesicles. Pharmacokinetic profiles of Tramadol in plasma and brain and of Ketoprofen in plasma were also assessed. The analgesic effect of each of the three tested drugs was evaluated in the acetic acid mice model for pain. One important result obtained in this work is that the concentration of Tramadol in rats’ plasma and brain increased rapidly after administration, reaching a peak value 10 min after administration with a Cmax of 2 to 5 folds greater than that for the oral or nasal non-vesicular treatments, respectively. In the case of Ketoprofen, the peak of the drug level in plasma was measured 10 min post nasal administration in NVS. The Cmax was three-fold higher relative to oral administration of this drug. In the experiment testing analgesia, a rapid and improved analgesia was observed for the tested drugs when delivered nasally in the nanocarrier. On the other hand, a weaker analgesic effect was observed for oral and nasal control systems. This new approach suggests that nasal delivery of non-controlled drugs in soft nanovesicles may open the way for better and noninvasive treatment of severe pain.
Role of the Pharmacist in Managing Treatment-Resistant Depression: A Focus on Ketamine
Authors: Liu Linda Xing Yu , Golts Marina , Fernandes Virginia
Published: June 2021

The impact of depression is well described in the literature, and it is most prominent in patients who have trialed multiple treatments. Treatment-resistant depression (TRD) is particularly debilitating, and it is associated with significant morbidity and mortality. Despite this, there seems to be therapeutic inertia in adopting novel therapies in current practice. Ketamine is an N-methyl-D-aspartate receptor antagonist and anesthetic agent which has recently been shown to be effective in the management of TRD when administered intravenously or intranasally. The treatments, however, are not easily accessible due to restrictions in prescribing and dispensing, high costs, and the slow uptake of evidence-based practice involving ketamine within the Canadian healthcare system. Given the limited treatment options for TRD, novel approaches should be considered and adopted into practice, and facilitated by a multi-disciplinary approach. Pharmacists play a critical role in ensuring access to quality care. This includes dissemination of evidence supporting pharmacological treatments and facilitating translation into current practice. Pharmacists are uniquely positioned to collaborate with prescribers and assess novel treatment options, such as ketamine, address modifiable barriers to treatment, and triage access to medications during transitions of care. Extending the reach of these novel psychiatric treatments in both tertiary and primary care settings creates an emerging role for pharmacists in the collaborative effort to better manage treatment-resistant depression.