bluuebunny/crossref_metadata_2025 huggingface dataset:
Through a Glass Cliff Darkly
Authors: Ihmels Anika , Haslam S. Alexander , Shemla Meir , Wegge Jürgen
Published: November 2022

Abstract: After breaking through the glass ceiling, women often obtain precarious or risky leadership positions in crisis-ridden organizations ( the glass cliff; Ryan & Haslam, 2005 ). Due to women’s minority status, their appointment in a crisis can signal important changes to organizational stakeholders indicating the use of new strategies for overcoming the crisis (signaling theory; Spence, 1973 ). Our study examines whether the media visibility of organizations moderates these signaling effects in ways that either strengthen or weaken glass cliffs. We augmented the archival dataset used by Haslam et al. (2010 ) in which the glass cliff phenomenon was discovered by including data on the media coverage that the Financial Times Stock Exchange index 100 companies received between 2001 and 2005. Our analysis shows that glass cliffs were more pronounced in companies with low media visibility. This suggests that the media visibility of organizations can contribute to increased accountability regarding their personnel decisions in ways that expose women leaders to less discrimination.
An Analytical Model of Two‐Dimensional Mesoscale Circulation and Associated Properties Across Squall Lines
Authors: Zhang Minghua
Published: November 2022

Mesoscale convective systems (MCS) contribute about half of the world's precipitation and create flash flooding as well as other extreme weather events. Despite steady progress in research of these systems in the last several decades, better theoretical understanding is still needed to understand their dynamical organizations and to improve their forecasts in numerical models. By using the Moncrieff‐Green horizontal vorticity equation, this paper presents an analytical model of one type of MCS, the steady‐state squall lines. It describes the organization, propagation, and properties of mesoscale circulations of two‐dimensional steady‐state convective systems under sheared environment. Far‐side solutions are formulated to illustrate the underlying physical processes of squall line flows. Numerical procedures are described to solve the model under general environmental conditions. The model leads to the following prediction of squall line properties: Given the environmental profiles of wind and convective available potential energy (CAPE), the propagation speed, the depths and mass fluxes of the tilted ascending front‐to‐rear flow, the overturning updraft, and the descending rear inflow of the squall line can be all determined from the cold pool buoyancy or CAPE. The squall lines are therefore self‐organized dynamical systems that have limited degrees of freedom in their properties. The model advances the theoretical understanding of how mesoscale flow components interact to sustain organized convection. It provides a new tool to interpret squall line systems in high resolution models and to parameterize them in climate models.
Seaward‐Dipping Reflector Influence on Seafloor Magnetostratigraphy—A Pelotas Basin View
Authors: Serratt Henrique , Domingues Teixeira Claudia , Girelli Tiago Jonatan , de Souza Marcelo Kehl , Rodrigues Vargas Mateus , Moreira Silva Adalene , Chemale Farid
Published: November 2022

Previous works used marine magnetic survey data and interpreted magnetic anomalies related to seaward‐dipping reflectors (SDRs) as oceanic crust or SDR age constraints in the South Atlantic Ocean. However, we advise against using SDR‐related magnetic anomalies to constrain ages because of the mostly low‐dipping geometry causing the overlapping of rocks extruded during periods of different polarities. The data are difficult to interpret correctly because of the SDR compositional heterogeneity, sedimentary intercalations, variations in package thickness with different compositions and magnetic polarities, and the absence of a link between the SDR magmatic position and age. SDR‐related magnetic anomalies are mainly caused by magnetic susceptibility contrasts rather than remanent magnetism. Due to this complexity, the SDR geometry and variable composition make SDR‐related magnetic anomalies challenging to use for age constraints. The Pelotas Basin SDRs age cannot be estimated by magnetostratigraphy, and this method likely cannot constrain the age of any SDR wedge.
Extratropical Stratospheric Air Intrusions Over the Western North Pacific and the Genesis of Downstream Monsoon Low‐Pressure Systems
Authors: Vishnupriya S. , Suhas E. , Sandeep S.
Published: November 2022

Low‐pressure systems (LPS) are convectively coupled vortices that contribute nearly half of the summer monsoon rainfall over the Indian subcontinent. About one third of the boreal summer monsoon LPS are caused by downstream amplification of westward propagating disturbances from the western North Pacific (WNP). Analysis of downstream LPS events from 1979 to 2017 reveals that 43% of them are caused by extratropical stratospheric air intrusions over the WNP. Stratospheric air intrusions lead to high tropospheric potential vorticity (PV), and the downstream vortex seeds are observed to initiate and intensify to the southwest of the PV anomalies. The PV anomalies can deform the temperature in its neighborhood and cause adiabatic lifting, which in turn can induce and intensify low‐level cyclonic vortices. The subsequent intensification of the low‐level vortex is aided by deep convection, observed to the southwest of the PV anomaly, through vortex stretching and low‐level PV generation by diabatic heating.
Shallow Fracture Buffers High Elevation Runoff in Northwest Greenland
Authors: Culberg Riley , Chu Winnie , Schroeder Dustin M.
Published: November 2022

The expansion of refrozen ice slabs in Greenland's firn may enhance meltwater runoff and increase surface mass loss. However, the impermeability of ice slabs and the pathways for meltwater export from these regions remain poorly characterized. Here, we present ice‐penetrating radar observations of extensive meltwater infiltration and refreezing beneath ice slabs in Northwest Greenland. We show that these buried ice complexes form where supraglacial streams or lakes drain through surface crevasses into relict firn beneath the ice slabs. This suggests that the firn can continue to buffer mass loss from surface meltwater runoff and limit meltwater delivery to the ice sheet bed even after ice slabs have formed. Therefore, a significant time lag may exist between the initial formation of ice slabs and the onset of complete surface runoff and seasonal meltwater drainage to the subglacial system in interior regions of the ice sheet.
The Impact of Winds on AMOC in a Fully‐Coupled Climate Model
Authors: Roach Lettie A. , Blanchard‐Wrigglesworth Edward , Ragen Sarah , Cheng Wei , Armour Kyle C. , Bitz Cecilia M.
Published: November 2022

Here we investigate the role of the atmospheric circulation in the Atlantic Meridional Overturning Circulation (AMOC) by comparing a fully‐coupled large ensemble, a forced‐ocean simulation, and new experiments using a fully‐coupled global climate model where winds above the boundary layer are nudged toward reanalysis. When winds are nudged north of 45°N, agreement with RAPID array observations of AMOC at 26.5°N improves across several metrics. The phasing of interannual variability is well‐captured due to the response of the local Ekman component in both wind‐nudging and forced‐ocean simulations, however the variance remains underestimated. The mean AMOC strength is substantially reduced relative to the fully‐coupled model large ensemble, which is biased high, due to the impact of winds on surface buoyancy fluxes over the subpolar gyre. Nudging winds toward observations also reduces the 1979–2016 trend in AMOC, suggesting that improvement in the representation of the high‐latitude atmosphere is important for projecting long‐term AMOC changes.
Hydro‐Thermodynamic Processes at a Large Confluence Under Reservoir Regulation
Authors: Shi Lidi , Sun Jian , Lin Binliang , Liu Zhaowei , Zuo Xinyu
Published: November 2022

Confluences are ubiquitous and important components in river systems, and their hydrodynamic complexity attracts increasing attention. The flow pattern in a confluence is influenced by the planform geometry, momentum, discharge ratio and bed concordance/discordance. In recent years, flow density is found to be a significant factor in natural confluence flow patterns, while the generated hydrodynamic processes that affects mixing within confluences are not fully known, especially in large rivers under heavy human activities. In this study, we investigate the hydro‐thermodynamic processes at a major confluence in the Yangtze River using a three‐dimensional numerical model. The water level in the confluence zone is regulated seasonally by the Three Gorges Reservoir, that is, the zone is within the reservoir's fluctuating backwater reach. The results show that reservoir regulation alters flow patterns in the confluence zone significantly in both horizontal and vertical planes, including shrinking re‐circulation, complicated cross‐sectional vortexes, as well as weakened riverine mixing capacity. The density difference leads to changes in the hydro‐thermodynamic processes, especially in combination with the reservoir regulation. When the tributary water temperature is high, the generated buoyancy strengthens the secondary flow in the mainstream, which further enhances the lateral transport capacity and accelerates the water mixing. More importantly, it is found that the combined effect of reservoir regulation and thermal buoyancy alters the flow structure considerably in the confluence zone, and modifies the water transport mode in the mainstream. Thus, a dimensionless number S is defined to represent the lateral water transport capacity.
Biological roles of the RNA m6A modification and its implications in cancer
Authors: Hong Juyeong , Xu Kexin , Lee Ji Hoon
Published: November 2022

The N6-Methyladenosine (m6A) modification of RNA transcripts is the most prevalent and abundant internal modification in eukaryotic messenger RNAs (mRNAs) and plays diverse and important roles in normal biological processes. Extensive studies have indicated that dysregulated m6A modification and m6A-associated proteins play critical roles in tumorigenesis and cancer progression. However, m6A-mediated physiological consequences often lead to opposite outcomes in a biological context-dependent manner. Therefore, context-related complexity must be meaningfully considered to obtain a comprehensive understanding of RNA methylation. Recently, it has been reported that m6A-modified RNAs are closely related to the regulation of the DNA damage response and genomic integrity maintenance. Here, we present an overview of the current knowledge on the m6A modification and its function in human cancer, particularly in relation to the DNA damage response and genomic instability.
Spatiotemporal control of necroptotic cell death and plasma membrane recruitment using engineered MLKL domains
Authors: Taslimi Amir , Fields Kaiah M. , Dahl Kristin D. , Liu Qi , Tucker Chandra L.
Published: November 2022

Necroptosis is a form of programmed necrotic cell death in which a signaling cascade induces oligomerization of mixed lineage kinase domain-like (MLKL) protein, leading to plasma membrane rupture. Necroptotic cell death is recognized as important for protection against viral infection and has roles in a variety of diseases, including cancer and diabetes. Despite its relevance to health and disease states, many questions remain about the precise mechanism of necroptotic cell death, cellular factors that can protect cells from necroptosis, and the role of necroptosis in disease models. In this study, we engineered a light-activated version of MLKL that rapidly oligomerizes and is recruited to the plasma membrane in cells exposed to light, inducing rapid cell death. We demonstrate this tool can be controlled spatially and temporally, used in a chemical genetic screen to identify chemicals and pathways that protect cells from MLKL-induced cell death, and used to study signaling responses of non-dying bystander cells. In additional studies, we re-engineered MLKL to block its cell-killing capacity but retain light-mediated membrane recruitment, developing a new single-component optogenetic tool that allows modulation of protein function at the plasma membrane.
Loss of function of CMPK2 causes mitochondria deficiency and brain calcification
Authors: Zhao Miao , Su Hui-Zhen , Zeng Yi-Heng , Sun Yuan , Guo Xin-Xin , Li Yun-Lu , Wang Chong , Zhao Zhi-Yuan , Huang Xue-Jing , Lin Kai-Jun , Ye Zi-Ling , Lin Bi-Wei , Hong Shunyan , Zheng Jitan , Liu Yao-Bin , Yao Xiang-Ping , Yang Dehao , Lu Ying-Qian , Chen Hai-Zhu , Zuo Erwei , Yang Guang , Wang Hong-Tao , Huang Chen-Wei , Lin Xiao-Hong , Cen Zhidong , Lai Lu-Lu , Zhang Yan-Ke , Li Xi , Lai Tianmin , Lin Jingjing , Zuo Dan-Dan , Lin Min-Ting , Liou Chia-Wei , Kong Qing-Xia , Yan Chuan-Zhu , Xiong Zhi-Qi , Wang Ning , Luo Wei , Zhao Cui-Ping , Cheng Xuewen , Chen Wan-Jin
Published: November 2022

Brain calcification is a critical aging-associated pathology and can cause multifaceted neurological symptoms. Cerebral phosphate homeostasis dysregulation, blood-brain barrier defects, and immune dysregulation have been implicated as major pathological processes in familial brain calcification (FBC). Here, we analyzed two brain calcification families and identified calcification co-segregated biallelic variants in the CMPK2 gene that disrupt mitochondrial functions. Transcriptome analysis of peripheral blood mononuclear cells (PBMCs) isolated from these patients showed impaired mitochondria-associated metabolism pathways. In situ hybridization and single-cell RNA sequencing revealed robust Cmpk2 expression in neurons and vascular endothelial cells (vECs), two cell types with high energy expenditure in the brain. The neurons in Cmpk2-knockout (KO) mice have fewer mitochondrial DNA copies, down-regulated mitochondrial proteins, reduced ATP production, and elevated intracellular inorganic phosphate (Pi) level, recapitulating the mitochondrial dysfunction observed in the PBMCs isolated from the FBC patients. Morphologically, the cristae architecture of the Cmpk2-KO murine neurons was also impaired. Notably, calcification developed in a progressive manner in the homozygous Cmpk2-KO mice thalamus region as well as in the Cmpk2-knock-in mice bearing the patient mutation, thus phenocopying the calcification pathology observed in the patients. Together, our study identifies biallelic variants of CMPK2 as novel genetic factors for FBC; and demonstrates how CMPK2 deficiency alters mitochondrial structures and functions, thereby highlighting the mitochondria dysregulation as a critical pathogenic mechanism underlying brain calcification.
Equivalence checking of quantum circuits by nonlocality
Authors: Sun Weixiao , Wei Zhaohui
Published: November 2022

Suppose two quantum circuit chips are located at different places, for which we do not have any prior knowledge, and cannot see the internal structures either. In such a situation, a realistic and fundamental problem is to find out whether they have the same functions or not with certainty. In this paper, we show that this problem can be solved completely from the viewpoint of quantum nonlocality. Specifically, we design an elegant protocol that examines underlying quantum nonlocality, where the strongest nonlocality can be observed if and only if two quantum circuits are equivalent to each other. We show that the protocol also works approximately, where the distance between two quantum circuits can be calculated accurately by observing quantum nonlocality in an analytical manner. Furthermore, it turns out that the computational cost of our protocol is independent of the size of compared quantum circuits. Lastly, we also discuss the possibility to generalize the protocol to multipartite cases, i.e., if we do equivalence checking for multiple quantum circuits, we try to solve the problem in one go.
Low baseline ischemic water uptake is directly related to overestimation of CT perfusion-derived ischemic core volume
Authors: McDonough Rosalie , Elsayed Sarah , Meyer Lukas , Ewers Theresa , Bechstein Matthias , Kniep Helge , Nawka Marie Teresa , Faizy Tobias D. , Schön Gerhard , Thomalla Götz , Fiehler Jens , Hanning Uta , Kemmling Andre , Broocks Gabriel
Published: November 2022

Computed-tomography perfusion (CTP) is frequently used to screen acute ischemic stroke (AIS) patients for endovascular treatment (EVT), despite known problems with ischemic “core” overestimation. This potentially leads to the unfair exclusion of patients from EVT. We propose that net water uptake (NWU) can be used in addition to CTP to more accurately assess the extent and/or stage of tissue infarction. Patients treated for AIS between 06/2015 and 07/2020 were retrospectively analyzed. Baseline CTP-derived core volume (pCore) and NWU were determined. Logistic regression tested the relationship between baseline clinical and imaging variables and core-overestimation (primary outcome). The secondary outcomes comprised 90-day functional independence (modified Rankin score) and lesion growth. 284 patients were included. Median NWU was 7.2% (IQR 2.6–12.8). ASPECTS (RR 1.28, 95% CI 1.09–1.51), NWU (RR 0.94, 95% CI 0.89–0.98), onset to recanalization (RR 1.00, 95% CI 0.99–1.00) and imaging (RR 1.00, 95% CI 1.00–1.00) times, and pCore (RR 1.02, 95% CI 1.01–1.02) were significantly associated with core overestimation. Core-overestimation was more likely to occur in patients with large pCores and low NWU at baseline. NWU was significantly correlated with lesion growth. We conclude that NWU can be used as a supplemental tool to CTP during admission imaging to more accurately assess the extent of ischemia, particularly relevant for patients with large CTP-defined cores who would otherwise be excluded from treatment.
Urban water supply systems’ resilience under earthquake scenario
Authors: Bata Mo’Tamad H. , Carriveau Rupp , Ting David S.-K.
Published: November 2022

Threats to water supply systems have increased in number and intensity. Natural disasters such as earthquakes have caused different types of damage to water distribution networks (WDN), particularly for those with aged infrastructure. This paper investigates the resilience of an existing water distribution network under seismic hazard. An earthquake generation model coupled with a probabilistic flow-based pressure driven demand hydraulic model is investigated and applied to an existing WDN. A total of 27 earthquake scenarios and 2 repair strategies were simulated. The analysis examined hydraulic resilience metrics such as pressure, leak demand, water serviceability, and population impacted. The results show that nodal pressure drops below nominal pressure and reaches zero in some earthquake scenarios. Leak demand could reach to more than 10 m3/s within hours following an earthquake. Water serviceability drops to a low of 40% and population impacted reaches up to 90% for a 6.5 M earthquake, for example. This study highlights and quantifies vulnerabilities within the simulated WDN. The tools outlined here illustrate an approach that can: (1) ultimately help to better inform utility water safety plans, and (2) prepare proactive strategies to mitigate/repair before a hazard of this nature occurs.
A stable, engineered TL1A ligand co-stimulates T cells via specific binding to DR3
Authors: Zwolak Adam , Chan Szeman Ruby , Harvilla Paul , Mahady Sally , Armstrong Anthony A. , Luistro Leopoldo , Tamot Ninkka , Yamada Douglas , Derebe Mehabaw , Pomerantz Steven , Chiu Mark , Ganesan Rajkumar , Chowdhury Partha
Published: November 2022

TL1A (TNFSF15) is a TNF superfamily ligand which can bind the TNFRSF member death receptor 3 (DR3) on T cells and the soluble decoy receptor DcR3. Engagement of DR3 on CD4+ or CD8+ effector T cells by TL1A induces downstream signaling, leading to proliferation and an increase in secretion of inflammatory cytokines. We designed a stable recombinant TL1A molecule that (1) displays high monodispersity and stability, (2) displays the ability to activate T cells in vitro and in vivo, and (3) lacks binding to DcR3 while retaining functional activity via DR3. Together these results suggest the TL1A ligand can be amenable to therapeutic development on its own or paired with a tumor-targeting moiety.
High-dose extended-field radiotherapy plus chemotherapy improved survival in extranodal NK/T-cell lymphoma in a real-life setting: results from the multicenter T-Cell Brazil Project
Authors: de Pádua Covas Lage Luís Alberto , Machado Pedro Paulo Faust , Reichert Cadiele Oliana , Miranda Eliana , Culler Hebert Fabrício , da Siqueira Sheila Aparecida Coelho , de Oliveira Costa Renata , Miyashiro Dênis Ricardo , Sanches José Antônio , Rocha Vanderson , Chiattone Carlos Sérgio , Pereira Juliana
Published: November 2022

Extranodal natural-killer/T-cell lymphoma (ENKTL) is a rare and aggressive Epstein-Barr virus related mature T-cell and natural-killer malignancy. Although highly prevalent in South America, few studies covering data from this geographic location have been published. Therefore, this study aims to report clinical characteristics, prognostic factors, and outcomes in a multicenter cohort of ENKTL patients from Brazil. This retrospective, observational and multicenter study included 98 ENKTL patients treated during two decades in Brazil. Data were extracted from the T-Cell Brazil Project database. In our cohort, 59/98 patients (60.2%) were male, with a median age of 50 years. Sixty-two patients (63.3%) had B-symptoms, 26/98 (26.5%) had Eastern Cooperative Oncology Group scale ≥ 2; 16/98 (16.3%) presented extranasal disease and 34.7% (34/98) were advanced-stage (Ann Arbor/Cotswolds III/IV). The median follow-up for the whole cohort was 49 months, with an estimated 2-year overall survival (OS) and progression-free survival (PFS) of 51.1% and 17.7%, respectively. In early-stage disease (IE/IIE), the median OS was 21.8 months for patients treated with concurrent radiotherapy plus chemotherapy (CCRT-VIPD [etoposide/vp-16, ifosfamide, cisplatin and dexamethasone), 16.2 months for sequential chemoradiotherapy (SCRT) followed by asparaginase-based regimens, and 56.7 months for SCRT followed by CHOP-like (cyclophosphamide, doxorrubicin, vincristine and prednisone) treatments, p = 0.211. CCRT was associated with higher rates of early-mortality, hematological toxicity, and mucositis. Median OS was 8.2 months for patients with advanced-stage disease receiving regimens containing asparaginase compared to 3.2 months for anthracycline-based therapy, p = 0.851. Chemo-radiotherapy (CRT) regimens demonstrated better OS (p = 0.001) and PFS (p = 0.007) than chemotherapy alone. Multivariate analysis revealed anemia, relapsed/refractory (R/R) disease and radiotherapy omission as poor outcome predictors for OS. Lymphopenia and radiotherapy omission adversely affected PFS. Concerning progression of disease within 24-months (POD-24), clinical stage III/IV was a poor outcome predictor. In this real-life Brazilian cohort, ENKTL presented dismal outcomes. Radiation therapy was an independent factor for increased OS and PFS, but CCRT regimens were associated with higher toxicities. Polychemotherapy based on anti-multi drug resistant agents was not associated with survival benefit in either early or advanced-stage disease in our patient cohort.
Transverse abdominis plane block compared with patient-controlled epidural analgesia following abdominal surgery: a meta-analysis and trial sequential analysis
Authors: Jeong Young Hyun , Jung Ji-Yoon , Cho Hyeyeon , Yoon Hyun-Kyu , Yang Seong-Mi , Lee Ho-Jin , Kim Won Ho
Published: November 2022

Thoracic epidural analgesia (TEA) and transversus abdominis plane (TAP) block are used for pain control after abdominal surgery. Although there have been several meta-analyses comparing these two techniques, the conclusion was limited by a small number of studies and heterogeneity among studies. Our meta-analysis used the Medline, EMBASE, and Cochrane central library databases from their inception through September 2022. Randomized controlled trials (RCTs) comparing TEA and TAP block were included. The pre-specified primary outcome was the pain score at rest at 12 h postoperatively. Twenty-two RCTs involving 1975 patients were included. Pooled analyses showed the pain score at rest at 12 h postoperatively was significantly different between groups favoring TEA group (Mean difference [MD] 0.58, 95% confidence interval CI − 0.01, 1.15, P = 0.04, I2 = 94%). TEA group significantly reduced the pain score at 48 h at rest (MD 0.59, 95% CI 0.15, 1.03, P = 0.009, I2 = 86%) and at 48 h at movement (MD 0.53, 95% CI 0.07, 0.99, P = 0.03, I2 = 76%). However, there was no significant difference at other time points. Time to ambulation was shorter in TAP block but the incidence of hypotension at 24 h and 72 h was significantly lower in TAP block compared to TEA. Trial sequential analysis showed that the required information size has not yet been reached. Our meta-analysis demonstrated there was no significant or clinically meaningful difference in the postoperative pain scores between TEA and TAP block group. Given the insufficient information size revealed by TSA, the high risk of bias of our included studies, and the significant heterogeneity of our meta-analysis results, our results should be interpreted carefully but it is not likely that the addition of further studies could prove any clinically meaningful difference in pain score between these two techniques.
Open-circuit voltage of organic solar cells: interfacial roughness makes the difference
Authors: Poelking Carl , Benduhn Johannes , Spoltore Donato , Schwarze Martin , Roland Steffen , Piersimoni Fortunato , Neher Dieter , Leo Karl , Vandewal Koen , Andrienko Denis
Published: November 2022

Organic photovoltaics (PV) is an energy-harvesting technology that offers many advantages, such as flexibility, low weight and cost, as well as environmentally benign materials and manufacturing techniques. Despite growth of power conversion efficiencies to around 19 % in the last years, organic PVs still lag behind inorganic PV technologies, mainly due to high losses in open-circuit voltage. Understanding and improving open circuit voltage in organic solar cells is challenging, as it is controlled by the properties of a donor-acceptor interface where the optical excitations are separated into charge carriers. Here, we provide an electrostatic model of a rough donor-acceptor interface and test it experimentally on small molecule PV materials systems. The model provides concise relationships between the open-circuit voltage, photovoltaic gap, charge-transfer state energy, and interfacial morphology. In particular, we show that the electrostatic bias generated across the interface reduces the photovoltaic gap. This negative influence on open-circuit voltage can, however, be circumvented by adjusting the morphology of the donor-acceptor interface.
Hydrogen evolution reaction of Ben + H2O (n = 5–9) based on density functional theory
Authors: Diao Kai , Shi Shunping , Song Yong , Tang Leilei , Hu Jiabao , Jiang Jing , Duan Zhanjiang , Chen Deliang
Published: November 2022

Based on DFT, the lowest energy structure of Ben (n = 5–9) clusters, Ben@H2O (n = 5–9) complex and the hydrogen evolution reaction mechanism of Ben + H2O (n = 5–9) were studied.
Green carbon–carbon homocoupling of terminal alkynes by a silica supported Cu(ii)-hydrazone coordination compound
Authors: Heydari Neda , Bikas Rahman , Siczek Milosz , Lis Tadeusz
Published: November 2022

A new heterogeneous catalytic system based on a silica-supported Cu(ii) hydrazone complex has been prepared and used for the green homocoupling of terminal alkynes.
Anaerobic dissolved As(iii) removal from metal-polluted waters by cathode-stabilized Fe(iii)-oxyhydroxides
Authors: Valero Astolfo , Jan Jiří , Petrash Daniel A.
Published: November 2022

A bioelectrochemical method for arsenite scavenging from anoxic waters by Fe(iii) oxyhydroxides is feasible by boosting the microbial utilization of humic substance derivatives as electron shuttles for Fe mineral stabilization.
Rapid discovery of new Eu2+-activated phosphors with a designed luminescence color using a data-driven approach
Authors: Koyama Yukinori , Ikeno Hidekazu , Harada Masamichi , Funahashi Shiro , Takeda Takashi , Hirosaki Naoto
Published: November 2022

Machine learning in conjunction with validation experiments uncovers new Eu2+-activated phosphor materials with a designed green-color luminescence.
Fragment screening libraries for the identification of protein hot spots and their minimal binding pharmacophores
Authors: Whitehouse Rebecca L. , Alwan Wesam S. , Ilyichova Olga V. , Taylor Ashley J. , Chandrashekaran Indu R. , Mohanty Biswaranjan , Doak Bradley C. , Scanlon Martin J.
Published: November 2022

Small molecule interaction hotpots were identified by screening small, low complexity fragments using X-ray crystallography. These hot spots include cryptic pockets and provide pharmacophore mapping that may be used in structure-based drug design.
Polymeric nanoparticle-based nanovaccines for cancer immunotherapy
Authors: Zhang Yongxin , Chen Jiajing , Shi Linqi , Ma Feihe
Published: November 2022

Polymeric nanoparticle-based cancer vaccines with the components of antigens (ex vivoandin situ) and different immune adjuvants.
Selective photo-reduction of CO2 to methanol using Cu-doped 1D-Bi2S3/rGO nanocomposites under visible light irradiation
Authors: Mandal Arindam , Maitra Soumyajit , Roy Subhasis , Hazra Baisakhi , Ray Koustuv , Kargupta Kajari
Published: November 2022

The optimum (1 wt%) Cu-doped 1D-Bi2S3/rGO, a robust photocatalyst, selectively reduces CO2 to methanol at 719 μmol gcat.−1 h−1.
Isocyanide chemistry enabled by continuous flow technology
Authors: Cerra Bruno , Blondeau Cecile , Cannalire Rolando , Giustiniano Mariateresa , Tali Shandiz Shiva , Gioiello Antimo
Published: November 2022

The potential of continuous flow technology to streamline the synthesis, purification and postmodification reactions of isocyanides is reported.
A global view on star formation: The GLOSTAR Galactic plane survey
Authors: Dzib S. A. , Yang A. Y. , Urquhart J. S. , Medina S.-N. X. , Brunthaler A. , Menten K. M. , Wyrowski F. , Cotton W. D. , Dokara R. , Ortiz-León G. N. , Rugel M. R. , Nguyen H. , Gong Y. , Chakraborty A. , Beuther H. , Billington S. J. , Carrasco-Gonzalez C. , Csengeri T. , Hofner P. , Ott J. , Pandian J. D. , Roy N. , Yanza V.
Published: November 2022

As part of the Global View on Star Formation (GLOSTAR) survey we have used the Karl G. Jansky Very Large Array (VLA) in its B-configuration to observe the part of the Galactic plane between longitudes of 28° and 36° and latitudes from −1° to +1° at the C-band (4–8 GHz). To reduce the contamination of extended sources that are not well recovered by our coverage of the (u, υ)-plane, we discarded short baselines that are sensitive to emission on angular scales >4″. The resulting radio continuum images have an angular resolution of 1.″0 and a sensitivity of ~60 µJy beam−1, making it the most sensitive radio survey covering a large area of the Galactic plane with this angular resolution. An automatic source extraction algorithm was used in combination with visual inspection to identify a total of 3325 radio sources. A total of 1457 radio sources are ≥7σ and comprise our highly reliable catalog; 72 of these are grouped as 22 fragmented sources, for example, multiple components of an extended and resolved source To explore the nature of the cataloged radio sources, we searched for counterparts at millimeter and infrared wavelengths. Our classification attempts resulted in 93 H II region candidates, 104 radio stars, and 64 planetary nebulae, while it is suggested that most of the remaining radio sources are extragalactic sources. We investigated the spectral indices (α, Sv ∝ vα) of radio sources classified as H II region candidates and found that many have negative values. This may imply that these radio sources represent young stellar objects that are members of the star clusters around the high-mass stars that excite the H II regions, but not these H II regions themselves. By comparing the peak flux densities from the GLOSTAR and CORNISH surveys, we have identified 49 variable radio sources, most of them with an unknown nature. Additionally, we provide a list of 1866 radio sources detected within 5 to 7σ levels.
The effects of coagulant types on the quality and added value of raw rubber materials
Authors: Hutapea Yanter , Eliza Maryana Yeni , Karman Joni , Hanapi Sidiq , Raharjo Budi
Published: November 2022

Many processing problems still occur, causing the low quality of raw rubber materials and farmers low-income. This can be seen from the use of coagulants, storage methods and the level of cleanliness. This study was aimed at analyzing the quality and added value of raw rubber materials based on the use of coagulant types. This study was conducted in October - November 2021. Fresh latex was obtained from the rubber plantation in Mulyaguna Village, OKI Regency. Completely randomized design was used with 5 treatments and 4 replications. The coagulants used were the recommended ones (liquid smoke, formic acid), and the commonly used by the farmers (sulfuric acid, aluminum sulfate, and TSP fertilizer). The results of the study showed that liquid smoke and formic acid were better than the coagulants commonly used by farmers, which could be seen from the ash content, initial plasticity, and plasticity retention index. The dry rubber contents (DRCs) using liquid smoke, formic acid, sulfuric acid, aluminum sulfate, and TSP fertilizer were 66.081; 62.978; 59.067; 56.202 and 60.796 respectively. Liquid smoke and formic acid provided the added value for raw rubber materials of 1,203/kg IDR and 792/kg IDR compared to sulfuric acid commonly used by farmers.
Application of the business incubation model to social entrepreneurship programs: a case study of extreme poverty in Brebes district
Authors: Budi Pramono Taufik , Satriani Ratna , Christiany Dwi Utami Boru Situmorang Sawitania , Sunendar  , Johanda Putra Joni , Wijayanti Nur
Published: November 2022

The phenomenon of social entrepreneurship had grown rapidly along with poverty alleviation efforts. The Director General of Social Empowerment of the Ministry of Social Affairs seeks to develop innovative poverty reduction programs by carrying out social empowerment efforts through the Social Entrepreneurship Program (Prokus) collaboration with the Pusat Inkubator Bisnis LPPM UNSOED. This research’s aims were: 1) Identify the KPM profile of the Social Entrepreneurship Program in Brebes Regency, 2) Find out the pattern of incubation for the Social Entrepreneurship Program in Brebes Regency. Qualitative analysis was used in this study. The sampling method was carried out census on 300 KPM spread over 38 villages or sub districts in Brebes Regency. From this research, it shows that 94.3% of KPM ran a business in the Agribusiness sector, as much as 96.5% use family labor, the length of business that has been run for more than 5 years is 59.7%, the income per day below IDR 50,000 was 93%. Business incubation assistance can help increase KPM graduations. The assistance includes financial literacy, Business Model Canvas (BMC) training, Good Food Processing Practice training and packaging techniques, online marketing, product branding, business model development and networking.
Sustainability of KUB chicken business from human capital perspective: case study from central Lombok regency
Authors: Mardiana  , Taqiuddin Moh. , Hilmiati Nurul
Published: November 2022

KUB chicken has a great business potency for small enterprise to meet the growing demand of raw material for culinary tourism named Taliwang Chicken, owing to its fast growth trait. Human capital is very important in the management of KUB growing chicken enterprise to be sustainable from an economic, ecological, and social perspective. This paper aims to examine the sustainability of KUB growing chicken enterprise from the perspective of human capital. A survey was conducted from July to September 2021 in Central Lombok Regency as a center for developing of KUB chickens covering 35 farmers. The independent variable observed was human capital consisting of knowledge, skill, motivation, and attitude, while the dependent variable was business sustainability including economic sustainability, ecological sustainability, and social sustainability. These variables were measured using the Likert scale with five alternative answers. The study shows that the KUB growing chicken enterprise has a quite good level of sustainability in term of economic dimension, and high level in terms of ecological and social dimensions. Human capital assessment in the KUB growing chicken enterprise revealed quite high-range reflecting it’s have a great contribution to sustainability. Hence, it is concluded that human capital plays significant roles to sustain small scale KUB growing enterprise.
Effect of Instagram promotion on consumer purchase intention: evidence from Indonesian traditional food of bakpia
Authors: Rismalia Fedy , Akhmadi Heri , Rina Kamardiani Diah , Thai Phan Nguyen , Ameh Michael
Published: November 2022

Social media promotion is one of the current trends used to attract buyers, along with the massive use of information technology. One of them is using Instagram in promotional activities for traditional Indonesian food of Bakpia. This study aims to determine the effect of promotion through Instagram on consumer purchase intention of Bakpia. The study used descriptive method and multiple linear regression analysis. Four hundred respondents participated in this study through an online Google form survey. The results showed that promotional activities using Instagram were in good perception among consumers. Furthermore, based on the multiple regression analysis, the variable of context, communication, collaboration, and connection on Instagram promotion were statistically significant positive effect on purchase intention of bakpia consumers.
Gaining added value of chili (Capsicum annum L.) through processing and its challenges: A case in Bandung, West Java
Authors: Juliani Purba Helena , Ariningsih Ening , Sari Septanti Kartika , Suharyono Sri , Sinuraya Julia F.
Published: November 2022

Processing fresh chili into various chili products can generate added value. This study aims to assess the added value gained by processing fresh chili into its products and its challenges. Primary data was obtained through interviews using a structured questionnaire with the management of KWT Intan in Ciwidey, Bandung, which processes fresh chili into dried chili, chili powder, and chili sauce (sambal). This research was conducted in October 2019. Added value was calculated quantitatively using the Hayami method. The results show that the added value generated from processing fresh chili into dried chili is 17,743 IDR/kg, chili powder is 71,053 IDR/kg, and sambal is 326,128 IDR/kg. The results indicate the greatest added value obtained by processing fresh chili into sambal, which is a final product. However, developing the added value of chili products faces some challenges. The utilization of facility assistance and human resource skills is still limited, while consumers still prefer to consume fresh chili than processed ones. In an effort to increase the added value of chili and improve farmers' income, the government is expected to provide relevant regulations and assistance in the form of processing facilities and infrastructure as well as training, socialization, and promotion.
Customer loyalty toward delivery services at Kedai Ladanya Restaurant, Cianjur Regency, West Java
Authors: Muninggar Siti , Rozaki Zuhud , Arifin Ahmad Shabudin , Fairuz Ramli Mona
Published: November 2022

The food delivery service feature is a food delivery transaction that can be done via a handheld device or smartphone. The purpose of this study was to determine the characteristics of customers, identify the effect of service quality on customer satisfaction, and identify the influence of customers satisfaction on customers loyalty at Kedai Ladanya Restaurant. Data were collected using a questionnaire on 55 respondents who were customers at the Kedai Ladanya Restaurant with criteria aged 17 years and over, where buying food at the Kedai Ladanya Restaurant and had made transactions through the delivery service at the Kedai Ladanya Restaurant. The analysis used is simple linear regression analysis using SPSS 25 software. The results show that the percentage of characteristics for gender is female, for ages 17-20 years and 21-30 years, for the last education, namely high school/equivalent, for work namely students, the income is IDR. 1,000,000 – IDR. 3,000,000, for the average purchase frequency, which is less than three times per month, and the last delivery service used is GrabFood. The results showed that the relationship between service quality customer satisfaction and customers loyalty had a positive and significant effect.
Smallholder farmers behaviour to access bank in an integrated crop-livestock system in West Nusa Tenggara, Indonesia
Authors: Hilmiati Nurul , Cakra Putra Adnyana I Putu , Mardian Irma , Fitrotin Ulyatu , Hipi Awaludin , Mardiana  , Hidayah Nurul , Bulu Johanes G.
Published: November 2022

Agriculture is one of the most important sectors to support household economy in West Nusa Tenggara (WNT), dominated by small holder farmers. This paper aims to provide insight on smallholder farmers attitude to access bank under integrated crop-livestock system in WNT. A survey was conducted in 2021 in East Lombok, Sumbawa and Bima districts covering 103 farmers. This study found that farmers in Lombok has less interaction with bank compared to Sumbawa and Bima. Reasons mentioned were afraid to be unable to repay, no collateral, and no need to loan. Conversely, farmers in Sumbawa and Bima have accessed bank loan for more than 5 years to support crops and cattle farming. This difference was also associated with resources. Average land and cattle ownership per household in East Lombok were much lesser than in Sumbawa and Bima, 0,4 vs 2 and 0,7 ha respectively, and 1-2 vs 4-5 and 5-6 head respectively. Loan for crops farming often get repaid from selling cattle. Hence, it is concluded that farmers with more resources are keener to access bank loan as they have back up from different enterprise for repayment. Cattle play significant safeguard role to repay bank loan in an integrated crop-livestock system.
Innovations in healthy citrus garden management to reduce major pests and diseases and increase incomes of citrus farmers
Authors: Resiani Ni Made Delly , Sutami Ni Putu , Kamandalu A.A.N.B.
Published: November 2022

Healthy citrus garden management is an effort to optimize citrus yields. The research aims to suppress major pests and diseases and increase yields and incomes of citrus farmers. The research was conducted in Kintamani, Bali in January 2017-December 2020. The study was conducted in pairs in the form of 1 block of garden technology innovation treatment of healthy citrus gardens and 1 block of farmers' existing gardens. Plant samples per block were determined by purposive sampling. The results showed that the treatment had a significant effect on the abundance of fruit fly populations, diplodia infection, crop yields and farm income. There was a decrease in fruit fly population abundance and diplodia infection by 9.20 and 33.60%, the average citrus fruit yield was 23.71 t/ha. / year, there is an increase in citrus farming income by 97.19%/ha/year due to the innovation of healthy citrus gardens. Based on the calculation results, the R/C ratio and MBCR values were 1.96 and 2.55 for innovations with components of healthy citrus garden management. It is concluded that the technological innovation of healthy citrus gardens is feasible to be developed with the same type of agroecosystem.
Feasibility of water apple farming in Demak Regency
Authors: Rahmawati Nur , Adikusumo Irfan , Rozaki Zuhud
Published: November 2022

The development of water apple in Demak Regency has spread in all sub-districts. In addition to varying land areas, water apple productivity in each sub-district also varies from low to high. This could also be due to changes in the dry climate, which are longer than usual. This study aims at determining the investment costs, operational costs, benefits, and feasibility of water apple farming in Demak Regency. The research method used is descriptive analysis. Samples were determined purposively as many as 25 farmers from the existing population based on the age of the water apple plant. This study indicates that the investment cost used in the cultivation of water apple per 2000 m2 area is IDR 715,822,520, operating costs of IDR 814,209,869, and the resulting benefits of IDR 1,644,446,187. Water apple farming has a feasible category to run with a Net Present Value (NPV) of IDR 114,413,798; B/C of 1.15; Internal Rate of Return (IRR) of 7.20%; and Pay Back Period for 14.6 years. The potential of Demak district for water apple farming needs to be developed by rejuvenating it by the Standard Operating Procedures for water apple cultivation.
Feasibility of rice farming jajar legowo planting system in Dramaga, Ciomas, and Tamansari Sub-District, Bogor Regency
Authors: Adhi Alamsyah Astika , Anggarawati Sari , Eka Suwarnata Anak Agung
Published: November 2022

The area of land that applies the Jajar Legowo planting system is still little, it indicates there were only fewer farmers who applied this technology. Even though the implementation of that system is efficient to increase rice production and farmers' income in the Sub-District Dramaga, Ciomas, and Taman Sari. This study aims are to determine the application of rice farming with the Jajar Legowo planting system and to analyze the feasibility of farming in Dramaga, Ciomas and Tamansari Districts, Bogor Regency. The data obtained were processed quantitatively and qualitatively. Farming feasibility analysis used R/C and B/C ratios. The Jajar Legowo planting system applied by farmers was a 2:1 type, the area of the Jajar Legowo planting area was between 200 m2 – 1,500 m2 with an average yield of 1,214 kg per 1,000 m2. The results of the feasibility analysis of farming obtained an acceptance value of IDR 6,678,571 the total cost is IDR 3,226,190 therefore; farmers get income of IDR 3,452,381 in one growing season within an area of 1,000 m2. Obtaining an R/C value of 2.07 and a B/C value of 1.07, rice farming with the Jajar Legowo system is feasible and able to increase the farmer’s income.
Potential Utilization of Oil Palm Plantation Waste Supports Beef Cattle Development in West Sulawesi
Authors: Fitriawaty  , Sulkarnain  , Andriani Ida , Rahmi H , Nurhafsah  , Yanti Hayanti Sari , Yusriani Yenni
Published: November 2022

West Sulawesi Province has oil palm plantation areas that have the potential to be integrated with beef cattle. This study aims to collect data on feed availability from oil palm plantation waste and the carrying capacity of beef cattle development in West Sulawesi Province. The research method used is the desk study method that uses secondary data from Statistics Indonesia in 2022 related to oil palm plantations, palm oil production, and beef cattle populations, as well as research data relevant to this study. The data collected were analyzed descriptively. The results showed that West Sulawesi Province has oil palm plantation areas in 4 districts (Polewali Mandar, Mamuju, Central Mamuju, and Pasangkayu). The availability of dry matter from the plantation and palm oil processing waste is 479,554.04 Tons DM/year with a capacity of 210,330.72 LU/Year and can meet the needs of 317.61% of the beef cattle population from four districts. The index of feed availability from palm oil waste was highest in Pasangkayu Regency, with dry matter production of 11,298.8 tons DM/year. West Sulawesi Province has the potential to support the development of beef cattle with an integrated system of palm oil and cattle.