bluuebunny/crossref_metadata_2025 huggingface dataset:
Nephron-specific knockin of the PIKfyve-binding-deficient Vac14L156Rmutant results in albuminuria and mesangial expansion
Authors: Michgehl Ulf , Skryabin Boris V. , Bayraktar Samet , Vollenbröker Beate , Ciarimboli Giuliano , Heitplatz Barbara , Van Marck Veerle , Gröne Hermann-Josef , Pavenstädt Hermann , Weide Thomas
Published: August 2018

Intracellular trafficking processes play a key role for the establishment and maintenance of membrane surfaces in renal epithelia. Therefore, dysfunctions of these trafficking processes could be key events and important determinants in the onset and progression of diseases. The presence of cellular vacuoles—observed in many histologic analyses of renal diseases—is a macroscopic hint for disturbed intracellular trafficking processes. However, how vacuoles develop and which intracellular pathways are directly affected remain largely unknown. Previous studies showed that in some cases, vacuolization is linked to malfunction of the Vac14 complex. This complex, including the scaffold protein Vac14, the lipid kinase PIKfyve, and its counteracting lipid phosphatase Fig4, regulates intracellular phosphatidylinositol phosphate levels, which in turn, control the maturation of early-into-late endosomes, as well as the processing of autophagosomes into autophagolysosomes. Here, we analyzed the role of Vac14 in mice and observed that the nephron-specific knockin of the PIKfyve-binding-deficient Vac14L156Rmutant led to albuminuria, accompanied by mesangial expansion, increased glomerular size, and an elevated expression of several kidney injury markers. Overexpression of this Vac14 variant in podocytes did not reveal a strong in vivo phenotype, indicating that Vac14-dependent trafficking processes are more important for tubular than for glomerular processes in the kidney. In vitro overexpression of Vac14L156Rin Madin-Darby canine kidney cells had no impact on apico-basal polarity defects but resulted in a faster reassembly of junctional structures after Ca2+depletion and delayed endo- and transcytosis rates. Taken together, our data suggest that increased albuminuria of Vac14L156R-overexpressing mice is a consequence of a lowered endo- and transcytosis of albumin in renal tubules.
SAP102 regulates synaptic AMPAR function through a CNIH-2-dependent mechanism
Authors: Liu Mingna , Shi Rebecca , Hwang Hongik , Han Kyung Seok , Wong Man Ho , Ren Xiaobai , Lewis Laura D. , Brown Emery N. , Xu Weifeng
Published: August 2018

The postsynaptic density (PSD)-95-like, disk-large (DLG) membrane-associated guanylate kinase (PSD/DLG-MAGUK) family of proteins scaffold α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) complexes to the postsynaptic compartment and are postulated to orchestrate activity-dependent modulation of synaptic AMPAR functions. SAP102 is a key member of this family, present from early development, before PSD-95 and PSD-93, and throughout life. Here we investigate the role of SAP102 in synaptic transmission using a cell-restricted molecular replacement strategy, where SAP102 is expressed against the background of acute knockdown of endogenous PSD-95. We show that SAP102 rescues the decrease of AMPAR-mediated evoked excitatory postsynaptic currents (AMPAR eEPSCs) and AMPAR miniature EPSC (AMPAR mEPSC) frequency caused by acute knockdown of PSD-95. Further analysis of the mini events revealed that PSD-95-to-SAP102 replacement but not direct manipulation of PSD-95 increases the AMPAR mEPSC decay time. SAP102-mediated rescue of AMPAR eEPSCs requires AMPAR auxiliary subunit cornichon-2, whereas cornichon-2 knockdown did not affect PSD-95-mediated regulation of AMPAR eEPSC. Combining these observations, our data elucidate that PSD-95 and SAP102 differentially influence basic synaptic properties and synaptic current kinetics potentially via different AMPAR auxiliary subunits.

NEW & NOTEWORTHY Synaptic scaffold proteins postsynaptic density (PSD)-95-like, disk-large (DLG) membrane-associated guanylate kinase (PSD-MAGUKs) regulate synaptic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) function. However, the functional diversity among different PSD-MAGUKs remains to be categorized. We show that distinct from PSD-95, SAP102 increase the AMPAR synaptic current decay time, and the effect of SAP102 on synaptic AMPAR function requires the AMPAR auxiliary subunit cornichon-2. Our data suggest that PSD-MAGUKs target and modulate different AMPAR complexes to exert specific experience-dependent modification of the excitatory circuit.
Systemic Inflammation and Acute-on-Chronic Liver Failure: Too Much, Not Enough
Authors: Laleman Wim , Claria Joan , Van der Merwe Schalk , Moreau Richard , Trebicka Jonel
Published: August 2018

ACLF is a specific, but complex and multifactorial form of acute decompensation of cirrhosis and is characterized by an extraordinary dynamic natural course, rapidly evolving organ failure, and high short-term mortality. Dysbalanced immune function is central to its pathogenesis and outcome with an initial excessive systemic inflammatory response that drives organ failure and mortality. Later in its course, immuno-exhaustion/immunoparalysis prevails predisposing the patient to secondary infectious events and reescalation in end-organ dysfunction and mortality. The management of patients with ACLF is still poorly defined. However, as its pathophysiology is gradually being unravelled, potential therapeutic targets emerge that warrant further study such as restoring or substituting albumin via plasma exchange or via albumin dialysis and evaluating usefulness of TLR4 antagonists, modulators of gut dysbiosis (pre- or probiotics), and FXR-agonists.
Stability of the Diffusion Equation with a Source
Authors: Jung Soon-Mo , Min Seungwook
Published: August 2018

We will prove the generalized Hyers-Ulam stability of the (inhomogeneous) diffusion equation with a source, ut(x,t)-k△u(x,t)=f(x,t), for a class of scalar functions with continuous second partial derivatives.
Evaluation of BOX-PCR and ERIC-PCR as Molecular Typing Tools for PathogenicLeptospira
Authors: Bilung Lesley Maurice , Pui Chai Fung , Su’ut Lela , Apun Kasing
Published: August 2018

In the last decades, leptospirosis had gained public health concern due to morbidity and mortality rates caused by pathogenicLeptospira. The need for rapid and robust molecular typing methods to differentiate this zoonotic pathogen is of utmost importance. Various studies had been conducted to determine the genetic relatedness ofLeptospiraisolates using molecular typing methods. In this study, 29 pathogenicLeptospiraisolates from rat, soil, and water samples in Sarawak, Malaysia, were characterized using BOX-PCR and ERIC-PCR. The effectiveness of these two methods with regard to the ease of interpretation, reproducibility, typeability, and discriminatory power was also being evaluated. Using BOX-PCR, six clusters and 3 single isolates were defined at a genetic distance percentage of 11.2%. ERIC-PCR clustered the isolates into 6 clusters and 2 single isolates at a genetic distance percentage of 6.8%. Both BOX-PCR and ERIC-PCR produced comparable results though the discriminatory index for ERIC-PCR (0.826) was higher than that for BOX-PCR (0.809). From the constructed dendrogram, it could be summarized that the isolates in this study were highly heterogeneous and genetically diverse. The findings from this study indicated that there is no genetic relatedness among the pathogenicLeptospiraisolates in relation to the locality, source, and identity, with some exceptions. Out of the 29 pathogenicLeptospiraisolates studied, BOX-PCR and ERIC-PCR successfully discriminated 4 isolates (2 isolates each) into the same cluster in relation to sample sources, as well as 2 isolates into the same cluster in association with the sample locality. Future studies shall incorporate the use of other molecular typing methods to make a more thorough comparison on the genetic relatedness of pathogenicLeptospira.
Biopolymer from Adenanthera pavonina L. Seeds: Characterization, Photostability, Antioxidant Activity, and Biotoxicity Evaluation
Authors: Melo Roberta Cardoso , Geronço Maurycyo Silva , Sousa Rayran Walter Ramos , Ramos Lara Polyana Silva , Araújo Francisca Pereira , Ribeiro Alessandra Braga , Ferreira Paulo Michel Pinheiro , Osajima Josy Anteveli , Costa Marcília Pinheiro
Published: August 2018

Plant polysaccharides have been increasingly employed in the pharmaceutical, industrial, and food environments due to their versatile functional properties. In the present investigation, a heteropolysaccharide galactomannan (GAP) was extracted from Adenanthera pavonina L. seeds and characterized by physicochemical analyses to determine its thermal properties, photostability, antioxidant activity, and acute toxicity. GAP was characterized by FTIR, DSC, and TG. The photostability of GAP submitted to artificial UV irradiation was analyzed. Antioxidant activity was evaluated by the DPPH (2,2-diphenyl-1-1-picrylhydrazyl) free radical-scavenging method, while a bioassay method was carried out to study acute toxicity in Artemia salina L. Physical-chemical and functional characteristics of GAP support its potential role in the food and pharmaceutical industries. GAP was photostable under UV irradiation. In vitro GAP antioxidant evaluation showed that it bears free radical-scavenging activity for DPPH radicals. The median lethal concentration (LC50) of GAP was 239.4 mg∙mL−1, indicating that this biopolymer is nontoxic. Such results indicate that this biopolymer presents characteristics of neutrality, photostability, and nontoxicity that are commercially attractive.
High-Precision Heading Determination Based on the Sun for Mars Rover
Authors: Zhan Yinhu , Chen Shaojie , He Donghan
Published: August 2018

Since the American Mars Exploration Rover Opportunity landed on Mars in 2004, it has travelled more than 40 km, and heading-determination technology based on its sun sensor has played an important role in safe driving of the rover. A high-precision heading-determination method will always play a significant role in the rover’s autonomous navigation system, and the precision of the measured heading strongly affects the navigation results. In order to improve the heading precision to the 1-arcminute level, this paper puts forward a novel calibration algorithm for solving the comparable distortion of large-field sun sensor by introducing an antisymmetric matrix. The sun sensor and inclinometer alignment model are then described in detail to maintain a high-precision horizon datum, and a strict sun image centroid-extraction algorithm combining subpixel edge detection with circle or ellipse fitting is presented. A prototype comprising a sun sensor, electronic inclinometer, and chip-scale atomic clock is developed for testing the algorithms, models, and methods presented in this paper. Three field tests were conducted in different months during 2017. The results show that the precision of the heading determination reaches 0.28–0.97′ (1σ) and the centroid error of the sun image and the sun elevation are major factors that affect the heading precision.
Heat Treatment and Ventilation Optimization in a Deep Mine
Authors: Nie Xingxin , Wei Xiaobin , Li Xiaochen , Lu Caiwu
Published: August 2018

In order to address the issue of high temperatures and thermal damages in deep mines, the factors causing downhole heat damage at high temperatures were analyzed, the mine ventilation system was optimized and rebuilt, and a cooling system was established. The proposed cooling system uses mine water as the cooling source, and its features are based on the analysis of traditional cooling systems. The current ventilation system in the 1118 m deep pit of the Jinqu Gold Mine was evaluated, and the ventilation network, ventilation equipment, and ventilation structures near the underground working face were optimized. The low‐temperature mine water stored in the middle section of the mine at 640 m depth was used as the cooling source, and a cooling system was established near the 440 m deep middle return well to alleviate the high‐temperature and high‐humidity conditions of the 280 m deep middle‐western area. The results show that the effective air volume in the west wing at 280 m was 3.0 m3/s, the operating ambient temperature was 27.6°C, the relative humidity was reduced to 76%, and the temperature was reduced by 5‐6°C after the optimization of the system.
Spontaneous Resolution of Symptomatic Hepatic Sarcoidosis
Authors: Nguyen Viva , Ngo Henry N. , Awad Hamza H.
Published: August 2018

Sarcoidosis is an inflammatory process of unknown etiology, characterized by noncaseating granulomas. Isolated extrapulmonary disease is rare. We present a case of a 60-year-old woman with chronically elevated alkaline phosphatase. Upon obtaining a liver biopsy, granulomatous hepatitis was observed, suggestive of sarcoidosis. No particular treatment was initiated, and 3 years following the onset of elevated alkaline phosphatase, her levels decreased spontaneously.
Contagious Criminal Career Models Showing Backward Bifurcations: Implications for Crime Control Policies
Authors: Raimundo Silvia Martorano , Yang Hyun Mo , Massad Eduardo
Published: August 2018

We provide a theoretical framework to study how criminal behaviors can be treated as an infectious phenomenon. There are two infectious diseases like models that mimic the role of convicted criminals in contaminating individuals not yet engaged in the criminal career. Equilibrium analyses of each model are studied in detail. The models proposed in this work include the social, economic, personal, and pressure from peers aspects that can, theoretically, determine the probability with which a susceptible individual with criminal propensity engages in a criminal career. These crime-inducing parameters are treated mathematically and their inclusion in the model aims to help policy-makers design crime control strategies. We propose, to the best of our knowledge by the first time in quantitative criminology, the existence of thresholds for the stability of crime-endemic equilibrium which are the equivalent to the “basic reproduction number” widely used in the mathematical epidemiology literature. Both models presented the phenomena of backward bifurcation and breaking-point when the contact rates are chosen as bifurcation parameters. The finding of backward bifurcation in both models implies that there is an endemic equilibrium of criminality even when the threshold parameter for contagion is below unit, which, in turn, implies that control strategies are more difficult to achieve considerable impact on crime control.
The Johnson Equation, Fredholm and Wronskian Representations of Solutions, and the Case of Order Three
Authors: Gaillard Pierre
Published: August 2018

We construct solutions to the Johnson equation (J) first by means of Fredholm determinants and then by means of Wronskians of order 2N giving solutions of order N depending on 2N-1 parameters. We obtain N order rational solutions that can be written as a quotient of two polynomials of degree 2N(N+1) in x, t and 4N(N+1) in y depending on 2N-2 parameters. This method gives an infinite hierarchy of solutions to the Johnson equation. In particular, rational solutions are obtained. The solutions of order 3 with 4 parameters are constructed and studied in detail by means of their modulus in the (x,y) plane in function of time t and parameters a1, a2, b1, and b2.
Aberrant Expression of miR-362 Promotes Lung Cancer Metastasis through Downregulation of Sema3A
Authors: Luo Dan , Zhang Zheng , Zhang Zhao , Li Jia-Yue , Cui Jian , Shi Wen-Pu , Dong Xi-Wen , Yuan Lin , Lin Peng , Chen Zhi-Nan , Bian Hui-Jie , Wang Zi-Ling
Published: August 2018

miR-362 is a recently discovered member of the microRNA family, and it modulates a variety of physical activities and plays an important role in the occurrence and development of many tumors. However, the biological functions of hsa-miR-362-5p in non-small-cell lung carcinoma (NSCLC) are unknown. Transwell assay and colony formation were used to determine the migration, invasion, and proliferation of NSCLC cells in vitro. A subcutaneous tumor model in nude mice was established to detect NSCLC tumor growth in vivo. The direct binding of miR-362 to the 3′UTR of Semaphorin 3A (Sema3A) was confirmed by luciferase reporter assay. In this study, we found that the level of miR-362 was higher in NSCLC tissues than in adjacent normal tissues and that the level of miR-362 expression was also elevated in five NSCLC cell lines (A549, 95-D, H1299, H292, and H460) relative to a human normal lung epithelial cell line (BEAS2B). Furthermore, miR-362 promoted NSCLC cell invasion, migration, and colony formation in vitro and tumor formation in vivo. Next, we identified the miR-362 target gene Sema3A, which is significantly correlated with metastasis. Sema3A expression was increased in normal tissues relative to NSCLC tissues. This result is consistent with the fact that miR-362 expression is negatively correlated with Sema3A expression in clinical tissue samples and indicated that miR-362 can regulate Sema3A expression in NSCLC cells and consequently affect NSCLC invasion, migration, and colony formation. Taken together, these findings on the newly identified miR-362/Sema3A axis elucidate the molecular mechanism of NSCLC invasion and migration and could lead to a potential therapeutic target in NSCLC treatment.
Push-Out Bond Strength of Experimental Apatite Calcium Phosphate Based Coated Gutta-Percha
Authors: Al-Haddad Afaf Y. , Kutty Muralithran G. , Che Ab Aziz Zeti Adura
Published: August 2018

Objectives. To evaluate the push-out bond strength of experimental apatite calcium phosphate coated gutta-percha (HAGP) compared to different commercially available coated gutta-percha root obturation points. Methods. Extracted teeth were selected and instrumented using ProTaper rotary files. The canals were assigned into five equal groups and obturated using matching single cone technique as follows: EndoREZ cones and EndoREZ sealer, Bioceramic Endosequence gutta-percha (BCGP) with Endosequence BC sealer, Active GP with Endosequence BC sealer (ActiV GP), conventional GP with Endosequence BC sealer, and HAGP with Endosequence BC sealer. Each root was sectioned transversally at the thickness of 1±0.1 mm to obtain 5 sections (n=25 per group). The specimens were subjected to push-out test using a Universal Test Machine at a loading speed of 0.5 mm/ min. Failure modes after push-out test was examined under stereomicroscope and the push-out data were analyzed using ANOVA and the post hoc Dunnett T3 test (p = 0.05). Results. The highest mean bond strength was yielded by HAGP followed by BCGP, ActiV GP, conventional GP, and EndoREZ. There were significant differences between EndoREZ and all other groups (p<0.001). The prominent failure mode of HAGP was mixed mode, whereas EndoREZ exhibited adhesive failure mode. Conventional GP, ActiV GP, and BCGP showed cohesive failure mode. Conclusion. HAGP showed promising results to be used as root canal filling material in combination with bioceramic sealer.
Plant Sources, Extraction Methods, and Uses of Squalene
Authors: Lozano-Grande M. Azalia , Gorinstein Shela , Espitia-Rangel Eduardo , Dávila-Ortiz Gloria , Martínez-Ayala Alma Leticia
Published: August 2018

Squalene (SQ) is a natural compound, a precursor of various hormones in animals and sterols in plants. It is considered a molecule with pharmacological, cosmetic, and nutritional potential. Scientific research has shown that SQ reduces skin damage by UV radiation, LDL levels, and cholesterol in the blood, prevents the suffering of cardiovascular diseases, and has antitumor and anticancer effects against ovarian, breast, lung, and colon cancer. The inclusion of SQ in the human diet is recommended without causing health risks; however, its intake is low due to the lack of natural sources of SQ and efficient extraction methods which limit its commercialization. Biotechnological advances have developed synthetic techniques to produce SQ; nevertheless, yields achieved are not sufficient for global demand for industrial or food supplement purposes. The effect on the human body is one of the scientific issues still to be addressed; few research studies have been developed with SQ from seed or vegetable sources to use it in the food sector even though squalene was discovered more than half a century ago. The aim of this review is to provide an overview of SQ to establish research focus with special reference to plant sources, extraction methods, and uses.
Modeling Cell‐to‐Cell Spread of HIV‐1 with Nonlocal Infections
Authors: Fan Xiaoting , Song Yi , Zhao Wencai
Published: August 2018

This paper is devoted to develop a nonlocal and time‐delayed reaction‐diffusion model for HIV infection within host cell‐to‐cell viral transmissions. In a bounded spatial domain, we study threshold dynamics in terms of basic reproduction number for the heterogeneous model. Our results show that if , the infection‐free steady state is globally attractive, implying infection becomes extinct, while if , virus will persist in the host environment.
A Dynamic Analysis of a Motor Vehicle Pollutant Emission Reduction Management Model Based on the SD-GM Approach
Authors: Jia Shuwei
Published: August 2018

The present study constructed a motor vehicle pollution charging management model by primarily reducing the trip volume of motor vehicles, introducing the charging mechanism, and employing integration of the system dynamics and grey model theory (SD-GM) from the perspective of the environment and society. To optimize the chosen parameters, the dynamic growth rate graphical function of the gross domestic product (GDP) was firstly generated based on the GM(1,1) prediction theory. In addition, verification was conducted in accordance with the degree of grey incidence. Secondly, the net migration rate was estimated based on the attraction degree of the city and the average net migration rate. The degree of PMx and NOx pollution was finally defined and endowed with different weights to define the degree of air pollution in accordance with the actual degree of air pollution in Beijing. In terms of model testing and verification, we conducted extreme condition tests and sensitivity tests and checked the residual error. Finally, this study analyzed and compared different policies, which indicate that the amount of motor vehicle trips (AMVT), the amount of PMx generation (APMG), the amount of NOx generation (ANOG), and the degree of air pollution (DAP) decreased by 31.01%, 26.52%, 21.29%, and 12.50%, respectively.
An Artificial Bee Colony Algorithm with Random Location Updating
Authors: Sun Lijun , Chen Tianfei , Zhang Qiuwen
Published: August 2018

As a novel swarm intelligence algorithm, artificial bee colony (ABC) algorithm inspired by individual division of labor and information exchange during the process of honey collection has advantage of simple structure, less control parameters, and excellent performance characteristics and can be applied to neural network, parameter optimization, and so on. In order to further improve the exploration ability of ABC, an artificial bee colony algorithm with random location updating (RABC) is proposed in this paper, and the modified search equation takes a random location in swarm as a search center, which can expand the search range of new solution. In addition, the chaos is used to initialize the swarm population, and diversity of initial population is improved. Then, the tournament selection strategy is adopted to maintain the population diversity in the evolutionary process. Through the simulation experiment on a suite of unconstrained benchmark functions, the results show that the proposed algorithm not only has stronger exploration ability but also has better effect on convergence speed and optimization precision, and it can keep good robustness and validity with the increase of dimension.
Research on Integrated Guidance and Control of Distributed Cooperation of Multi-Interceptor with State Coupling
Authors: Liu Xiang , Liang Xiaogeng
Published: August 2018

With the aim of achieving cooperative target interception by using multi-interceptor, a distributed cooperative control algorithm of the multi-interceptor with state coupling is proposed based on the IGC (integrated guidance and control) method. Considering the coupling relationship between the pitch and ya w channels, a state coupling “leader” IGC model is established, an FTDO (finite-time disturbance observer) is designed for estimating the unknown interference of the model, and the “leader” controller is designed according to the adaptive dynamic surface sliding-mode control law. Secondly, the cooperative control strategy of the multi-interceptor is designed with the “leader-follower” distributed network mode to obtain the speed in the three directions of the interceptor in air and transform them to the general flight speed, trajectory inclination angle, and trajectory deflection instruction by using the transformational relation of kinematics. Finally, the “follower” controller is designed with the FTDO and dynamic surface sliding-mode control. The designed multi-interceptor distributed cooperative IGC algorithm with state coupling has good stability according to the simulation results of two different communication topologies.
Condition Numbers of the Nonlinear Matrix Equation Xp-A⁎eXA=I
Authors: Chacha Chacha Stephen , Naqvi Syed Muhammad Raza Shah
Published: August 2018

We explore the condition numbers of the nonlinear matrix equation Xp-A⁎eXA=I. Explicit expressions for the normwise, mixed, and componentwise condition numbers are derived. The upper bounds for the mixed and componentwise condition numbers are obtained. The numerical result favors the fact that our estimations are fairly sharp. Also, the relative upper perturbation bounds give satisfactory results for small perturbations in the input data.
Forecasting China’s CO2 Emissions for Energy Consumption Based on Cointegration Approach
Authors: Li Xiangmei , Song Yan , Yao Zhishuang , Xiao Renbin
Published: August 2018

Forecasting CO2 emissions is important for climate policy decision making. The paper attempts to implement empirically the long-term forecast of CO2 emissions based on cointegration theory under the business-as-usual scenario, by using statistical data from China over the period 1953 to 2016. We focus on the relationships between CO2 emissions for energy consumption and influential factors: per capita GDP, urbanization level, energy intensity, and total energy consumption. The empirical results are presented as follows: (1) continuous increase of carbon pollution resulting from energy consumption (1953-2016) indicates that China has beard great pressure of carbon reduction. (2) Though reduction of carbon intensity in 2020 would account for 50.14% that of 2005, which meets the requirements announced by Chinese government in 2009, China would bear carbon emissions for energy consumption of 14.4853 billion tCO2 by 2030, which is nearly 1.59 times that of 2016 and nearly 105 times that of 1953. The results suggest that the policymakers in China may take more effective measures such as reducing energy intensities and formulating stricter environmental regulations in order to mitigate the CO2 emissions and realize the win-win of economic and ecological benefits.
Benign Multicystic Peritoneal Mesothelioma in a Male Patient with Previous Wilms’ Tumor: A Case Report and Review of the Literature
Authors: Canu Gian Luigi , Medas Fabio , Columbano Giulio , Gordini Luca , Saba Luca , Erdas Enrico , Calò Pietro Giorgio
Published: August 2018

Benign multicystic peritoneal mesothelioma (BMPM) is a rare condition, more common in females of reproductive age, which arises from the peritoneal mesothelium. A 33-year-old male presented to our unit with abdominal pain and constipation. His past medical history included a previous unilateral nephrectomy for Wilms’ tumor and the previous incidental finding of some intra-abdominal cystic formations at the level of the mesentery. After performing a CT scan, an exploratory laparotomy was done and a voluminous cystic mesenteric mass, composed of 3 confluent formations, was observed. Some other similar but significantly smaller lesions were found. An en bloc resection of the mesenteric mass together with the corresponding intestinal loops, an appendicectomy, and some peritoneal biopsies were performed. The postoperative period was complicated by a peritonitis due to dehiscence of the intestinal anastomosis, which required another operation, and a delayed return of normal bowel function, which was resolved through prokinetic therapy. Through histological examination, a BMPM was diagnosed. At 8 months of follow-up, the patient is free of symptoms. BMPM exact etiopathogenesis still remains uncertain. Given his high recurrence rate, a long-term follow-up is recommended.
Reversed S-Shaped Bifurcation Curve for a Neumann Problem
Authors: Xing Hui , Chen Hongbin , Yao Ruofei
Published: August 2018

We study the bifurcation and the exact multiplicity of solutions for a class of Neumann boundary value problem with indefinite weight. We prove that all the solutions obtained form a smooth reversed S-shaped curve by topological degree theory, Crandall-Rabinowitz bifurcation theorem, and the uniform antimaximum principle in terms of eigenvalues. Moreover, we obtain that the equation has exactly either one, two, or three solutions depending on the real parameter. The stability is obtained by the eigenvalue comparison principle.
A Novel Teaching-Learning-Based Optimization with Error Correction and Cauchy Distribution for Path Planning of Unmanned Air Vehicle
Authors: Zhai Zhibo , Jia Guoping , Wang Kai
Published: August 2018

Teaching-learning-based optimization (TLBO) algorithm is a novel heuristic method which simulates the teaching-learning phenomenon of a classroom. However, in the later period of evolution of the TLBO algorithm, the lower exploitation ability and the smaller scope of solutions led to the poor results. To address this issue, this paper proposes a novel version of TLBO that is augmented with error correction strategy and Cauchy distribution (ECTLBO) in which Cauchy distribution is utilized to expand the searching space and error correction to avoid detours to achieve more accurate solutions. The experimental results verify that the ECTLBO algorithm has overall better performance than various versions of TLBO and is very competitive with respect to other nine original intelligence optimization algorithms. Finally, the ECTLBO algorithm is also applied to path planning of unmanned aerial vehicle (UAV), and the promising results show the applicability of the ECTLBO algorithm for problem-solving.
Sex Differences in Sleep Duration among Older Adults with Self-Reported Diagnosis of Arthritis: National Health and Nutrition Examination Survey, 2009-2012
Authors: Wiener R. Constance , Shockey Alcinda K. Trickett , Waters Christopher
Published: August 2018

Objective. Sleep is restorative, essential, and beneficial to health. Prevalences of some diseases have been associated with sleep duration. There are few studies in the literature on the relationship of sleep duration and arthritis stratified by sex in older adults. The purpose of this research is to investigate sleep duration among older adults in the United States who have self-reported diagnosis of arthritis. Methods. A cross-sectional study design was used. The data source was the National Health and Nutrition Examination 2009-2010 and 2011-2012. Self-reported diagnosis of arthritis and sleep duration were the variables of interest. Results. There were 4,888 participants, aged 50 years and above, of whom 41.6% self-reported having a diagnosis of arthritis, and 60.6% were female. Of the people who had a self-reported diagnosis of arthritis, 15.2% reported sleeping 2-5 hours as compared with 10.9% of the people who did not have a self-reported diagnosis of arthritis (P=.0004). In bivariate analysis of self-reported diagnosis of arthritis and sleep stratified by sex, there were significantly more people with self-reported diagnosis of arthritis who slept 2-5 hours for both women (P=0.0192) and men (P=0.0231). The overall relationship remained significant in adjusted overall logistic regression comparing for self-reported diagnosis of arthritis for 2-5 hours of sleep (with 6-7 hours of sleep as the reference) (odds ratio: 1.35 [95% CI: 1.08, 1.70; P=0.0103]); however, when the data were stratified by sex, the association failed to reach significance. Conclusion. In this analysis of noninstitutionalized older adults in the United States, the prevalence of a self-reported diagnosis of arthritis was associated with shorter sleep duration in the overall analyses, but the association failed to reach significance when stratified by sex.
Efficiency Advantages and Incentive Mechanism of PPPs: A Qualitative Comparative Analysis under the Chinese Scenario
Authors: Dong Xiaowei , Du Yali , Wu Xianhua
Published: August 2018

Based on the PPP efficiency system which consists of allocation efficiency, process efficiency, and individual efficiency, we use qualitative comparison analysis of fuzzy sets to study the efficiency advantages of the public‐private partnership under the Chinese scenario. The findings are as follows: (1) like public‐private partnerships, Chinese‐style PPPs have also failed to achieve cooperation. (2) High allocation efficiency can be achieved if competition in bidding processes can be ensured; when bidding procedures cannot be guaranteed to compete, alternatives to high allocation efficiency are either privatized or allocated directly to enterprises that can enable economies of scale; individual effort is a source of allocation efficiency. (3) Competition and economies of scale are necessary conditions for high process efficiency. The private sector’s ownership of assets is a sufficient condition for high process efficiency. (4) High individual efficiency can be achieved if individual efforts can be ensured, and high individual efficiency can also be achieved by the competition of bidding procedures or economies of scale when it is impossible to ensure high levels of individual effort. Privatization is the perfect incentive for high individual efficiency when the competition in the bidding process, individual efforts, and economies of scale cannot be guaranteed.
Experimental Study on High‐Cycle Fatigue Behavior of GFRP‐Steel Sleeve Composite Cross Arms
Authors: Wang Jiantao , Tan Ning , Zhou Shiming , Sun Qing
Published: August 2018

To overcome the fatigue safety problem of transmission tower cross arms caused by the wind‐induced vibrations, an experimental study on the high‐cycle fatigue performance of a new type of GFRP‐steel sleeve composite cross arms was carried out. A total of six specimens were subjected to 500 thousand cyclic loadings based on the practical engineering background. The stress state was monitored, and a variety of load‐displacement‐time curves, the energy dissipation capacity, and the dynamic strain were analyzed to examine the effects of fatigue loading. After the fatigue test, the specimens without significant fatigue failure were evaluated to derive the residual bearing capacity. Based on the residual strength theory, the cumulative damage was examined, and the fatigue life was predicted under various loading conditions to ensure the reliability of composite cross arms. It is shown that the new type full‐scale GFRP‐steel sleeve composite cross arms can demonstrate a high level of safety redundancy on antifatigue performance and can be expected for wide application in power transmission towers.
Novel Synthetic-Based Drilling Fluid through Enzymatic Interesterification of Canola Oil
Authors: Paul Anawe A. L. , Adewale Folayan J.
Published: August 2018

Over the years, the oil industries have avoided aromatic, naphthenic, and paraffinic oils as drilling mud base fluids principally because of their detrimental environmental issues on pelagic and benthic marine ecosystems as a result of their toxicity and nonbiodegradability coupled with the possible deterioration of the oil itself and the rubber parts of the drilling equipment because the aromatic hydrocarbons present in the oil have a tendency to dissolve/damage elastomers present in rubber. Hence, possible insights into how to chemically and/or physically produce synthetic base drilling fluids whose cuttings are nontoxic, readily biodegradable, environmentally friendly, and of nonpetroleum source become imperative. In this study, enzymatic interesterification of canola oil was done with ethanol by using enzyme lipase as catalyst under optimum conditions of temperature and pressure and the physicochemical properties of the produced ester were evaluated and compared with that of diesel and a synthetic hydrocarbon base fluid (SHBF). Results show that the specific gravity, kinematic viscosity, dynamic viscosity, and surface tension of canola oil were reduced by 5.50%, 94.74%, 95.03%, and 9.38%, respectively, upon enzymatic interesterification to conform to standard requirements. Similarly, increased |mud ability to pump fluids and possibility of cold temperature environment can be achieved with the reduction in pour point and cloud point, respectively, of the produced canola oil ester. Finally, the produced ester showed no aromatic content as confirmed from its FTIR analysis which indicates its nontoxicity, biodegradability, and environmental friendliness.
Association between Carotid Wall Shear Rate and Arterial Stiffness in Patients with Hypertension and Atherosclerosis of Peripheral Arteries
Authors: Genkel Vadim V. , Salashenko Alexey O. , Shamaeva Tatyana N. , Sumerkina Veronika A. , Shaposhnik Igor I.
Published: August 2018

Aim. To evaluate carotid wall shear rate (WSR) in association with local and regional vascular stiffness in patients with hypertension (HTN) and atherosclerosis of peripheral arteries and to study the pattern of change of WSR in patients with HTN with increasing severity of peripheral artery atherosclerosis. Materials and Methods. Study involved 133 patients with HTN, 65 men and 48 women, aged in average 57.9±10.8 years. All patients were divided into four groups in accordance with ultrasound morphologic classification of vessel wall. Duplex scanning of carotid and lower limb arteries was performed. Carotid-femoral (cfPWV) and carotid-radial (crPWV) pulse wave velocity (PWV) were measured. Local carotid stiffness was evaluated by carotid ultrasound. Results. WSR of patients with plaques without and with hemodynamic disturbance was 416±128 s−1 and 405±117 s−1, respectively, which was significantly less than the WSR in patients with intact peripheral arteries – 546±112 s−1. Decreased carotid WSR was associated with increased crPVW, cfPWV, Peterson’s elastic modulus, decreased distensibility, and distensibility coefficient. Conclusion. In patients with HTN and atherosclerotic lesions of peripheral arteries, it is registered that the carotid WSR decreased with increasing severity of atherosclerosis. Decreased carotid WSR is associated with increased local carotid stiffness, regional vascular stiffness of muscular, and elastic vessels.
Amebic Encephalitis in a Patient with Chronic Lymphocytic Leukemia on Ibrutinib Therapy
Authors: Voshtina Ensi , Huang Huiya , Raj Renju , Atallah Ehab
Published: August 2018

Chronic lymphocytic leukemia (CLL) is the most common type of leukemia in Western countries. A common first-line therapy offered to qualifying patients includes ibrutinib, an oral covalent inhibitor of Bruton’s tyrosine kinase. Treatment of CLL with ibrutinib therapy is generally well tolerated; however, serious opportunistic infections are being reported in patients treated with ibrutinib. In this report, we present a patient with CLL on ibrutinib therapy who developed rapidly declining neurological status concerning for the central nervous system (CNS) process related to his immunocompromised status. Despite multiple testing modalities, no evidence was found to explain the acute changes the patient was experiencing, and he had no improvement with common antimicrobial coverage. The patient ultimately expired, and autopsy of the brain revealed granulomatous amebic encephalitis due to opportunistic infection by Acanthamoeba species. As evidenced by this case, ibrutinib therapy, despite being generally well tolerated, has the potential to predispose patients to opportunistic infections like amebic encephalitis. Amebic encephalitis is a highly lethal CNS infection, and it is important for clinicians to recognize early on the potential for infection in patients on ibrutinib therapy presenting with CNS symptoms.
Angelica gigas Nakai Has Synergetic Effects on Doxorubicin-Induced Apoptosis
Authors: Jeon Yong-Joon , Shin Jong-Il , Lee Sol , Lee Yoon Gyeong , Kim Ji Beom , Kwon Hak Cheol , Kim Sung Hun , Kim Inki , Lee Kyungho , Han Ye Sun
Published: August 2018

Natural products are valuable sources for drug discovery because they have a wide variety of useful chemical components and biological properties. A quick reevaluation of the potential therapeutic properties of established natural products was made possible by the recent development of the methodology and improvement in the accuracy of an automated high-throughput screening system. In this study, we screened natural product libraries to detect compounds with anticancer effects using HeLa cells. Of the 420 plant extracts screened, the extract of Angelica gigas Nakai (AGN) was the most effective in reducing cell viability of HeLa cells. Markers of apoptosis, such as exposure of phosphatidylserine and cleavage of caspase-7 and PARP, were increased by treatment with the AGN extract. Treatment of the AGN extract increased expression of PKR as well as ATF4 and CHOP, the unfolded protein response genes. In addition, cotreatment of doxorubicin and the AGN extract significantly increased doxorubicin-induced apoptosis in HeLa cells. Decursin and decursinol angelate, which were known to have anticancer effects, were the main components of the AGN extract. These results suggest that the extract of AGN containing, decursin and decursinol angelate, increases doxorubicin susceptibility.
Thermal Processing Effects on the Chemical Constituent and Antioxidant Activity of Okara Extracts Using Subcritical Water Extraction
Authors: Sun Hongyi , Yuan Xi , Zhang Zhenya , Su Xin , Shi Min
Published: August 2018

Subcritical water extraction (SWE) has been employed for the extraction of bioactive compounds from plant materials with cost-effectiveness, less consuming time, and environmental sustainability. To explore the effects of thermal processing during SWE, total organic content (TOC), total sugar, polysaccharides, total phenolic content (TPC), total flavonoid content (TFC), and antioxidant activity (ABTS and DPPH assays) of eight aqueous extracts have been quantitatively investigated. The results indicated that elevated temperatures indeed resulted in significant changes in the constituents and antioxidant activities of okara extracts. Among them, the extract obtained at 220°C exhibited the highest total phenolic, flavonoid content, DPPH (2,2-diphenyl-1-picrylhydrazyl) radical-scavenging activity, and ABTS [2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonate)] radical-scavenging activity. However, phenolic compounds were destroyed after the treatment above 230°C, suggesting that any polymer processing is improper to undertake at higher than this value to achieve the high antioxidant activity. Moreover, a significant positive correlation between TPC or TFC and antioxidant capacity (DPPH and ABTS) values was detected.
Nutritional and Biological Evaluation of Leaves of Mangifera indica from Mauritius
Authors: Jhaumeer Laulloo S. , Bhowon M. G. , Soyfoo S. , Chua L. S.
Published: August 2018

Mango trees are evergreen plants that are present all around Mauritius. In this study, mango leaves, Mangifera indica grown in Mauritius were investigated for their nutritional values involving proximate composition, total flavonoid (TFC), total phenolic (TPC), and mineral content, and phytochemicals as well as its antioxidant and antibacterial properties. The ash, crude fat, neutral detergent fiber (NDF), acid detergent fiber (ADF), and acid detergent lignin (ADL) of the mango leaves were found to be 12.61, 3.92, 35.32, 34.98, and 12.86%, respectively. The calcium content (2.15%) was above the normal required range, while the phosphorus content (0.12%) and crude protein content (13.60%) were within the normal required range of common fodders. The phytochemical results showed the presence of saponins, alkaloids, phenols, tannins, and flavonoids in the crude, EtOAC, and MeOH extracts. The values of TPC and TFC were higher for the EtOAC extract compared to the MeOH extract. Several secondary metabolites were identified from the leaves of the Mangifera indica which include 11 phenols, 4 xanthones, 9 flavanols, 10 benzophenones, 7 terpenoids, and 4 derivatives of gallotannins using UPLC-MS/MS. The presence of these metabolites is responsible for good antioxidant and antibacterial properties. Hence, mango leaves can be exploited for its potential use as a supplementary fodder for ruminants.
Modelling of Severe Accident and In-Vessel Melt Retention Possibilities in BWR Type Reactor
Authors: Valinčius Mindaugas , Kaliatka Tadas , Kaliatka Algirdas , Ušpuras Eugenijus
Published: August 2018

One of the severe accident management strategies for nuclear reactors is the melted corium retention inside the reactor pressure vessel. The work presented in this article investigates the application of in-vessel retention (IVR) severe accident management strategy in a BWR reactor. The investigations were performed assuming a scenario with the large break LOCA without injection of cooling water. A computer code RELAP/SCDAPSIM MOD 3.4 was used for the numerical simulation of the accident. Using a model of the entire reactor, a full accident sequence from the large break to core uncover and heat-up as well as corium relocation to the lower head is presented. The ex-vessel cooling was modelled in order to evaluate the applicability of RELAP/SCDAPSIM code for predicting the heat fluxes and reactor pressure vessel wall temperatures. The results of different ex-vessel heat transfer modes were compared and it was concluded that the implemented heat transfer correlations of COUPLE module in RELAP/SCDAPSIM should be applied for IVR analysis. To investigate the influence of debris separation into oxidic and metallic layers in the molten pool on the heat transfer through the wall of the lower head the analytical study was conducted. The results of this study showed that the focusing effect is significant and under some extreme conditions local heat flux from reactor vessel could exceed the critical heat flux. It was recommended that the existing RELAP/SCDAPSIM models of the processes in the debris should be updated in order to consider more complex phenomena and at least oxide and metal phase separation, allowing evaluating local distribution of the heat fluxes.
Voltammetric Behavior, Identifying and Quantitatively Determining Iron-Based Nanoparticles, and Evaluating Their Stability in Simulated Solutions of Gastric Juice
Authors: Dubova N. M. , Slepchenko G. B. , Khlusov I. A. , Ostapenko M. S. , Nesterov E. A.
Published: August 2018

The electrochemical behavior of Fe3O4 nanoparticles, iron nanoparticles coated with carbon, and diazonium salts by voltammetry methods using a carbon paste electrode (CPE) has been studied. There has been developed a voltammetric method for identifying and quantifying solid-phase iron-based nanoparticles in the background electrolyte of 0.02 mole/dm3 Trilon B (pH 3.5) with the use of the CPE. Investigations of nanoparticles’ stability with various coatings in a simulated solution of gastric juice have been carried out. Nanoparticles stability has been evaluated on the basis of determining Fe(III) ions in a simulated solution after contacting with nanoparticles within different periods of time using the method of inversion voltammetry. It has been shown that nanoparticles coated with carbon and salts of arendiazonium are the most resistant to aggressive media.