bluuebunny/crossref_metadata_2025 huggingface dataset:
The expression of nuclear factor of activated T cell c1 and receptor activator of nuclear factor kappa β induced by Enterococcus faecalis in osteoclastogenesis (laboratory experiment on Wistar rats)
Authors: Pribadi Nirawati , Rahmawati Rosita , Rukmo Mandojo , Tandadjaja Adelina Kristanti , Kurniawan Hendy Jaya , Hadi Ratna Puspita
Published: February 2020

Background: Enterococcus faecalis (E. faecalis) is the most common bacteria species in persistent endodontic infection of teeth undergoing root canal treatment at a prevalence of 38%. The virulence factor of this bacterium is Lipoteichoic acid (LTA) which can be recognized by Toll-like receptors-4 (TLR-4) that produce a stimulus and provoke an immune response. Inflammation results in bone defects that feature multiple cytokines and interactions between different cell types. Bone loss within a periapical tooth is characterized by osteoclast formation (osteoclastogenesis) in the bone. Purpose: This study aimed to determine the expression of nuclear factor of activated T cell c1 (NFATc1) and receptor activator of nuclear factor kappa β (RANK) which played a role in osteoclastogenesis at different time intervals. Methods: 36 upper molar teeth of the research subjects were induced with 106 CFU Enterococcus faecalis and subsequently observed for 7 and 21 days with the NFATc1 and RANK being counted microscopically at 1000X magnification across 20 viewing fields. Thereafter, the data was examined and analyzed by means of an independent T test using SPSS. Results: NFATc1 and RANK expression were higher in the group including E. faecalis on days 7 and 21 than in the control group. There were significant differences between the treatment group and control group with regard to NFATc1 and RANK expression (p<0.05). Conclusion: The study showed that the expression of NFATc1 and RANK, which plays a role in osteoclastogenesis, was higher in periapical bone defects in Wistar rats induced by E. faecalis than those which were not induced.
The correlation between exposure to cigarette smoke and the degree of mucosal epithelium-based dysplasia in Rattus norvegicus tongues
Authors: Prijaryanti Dorisna , Ernawati Diah Savitri , Radithia Desiana , Hendarti Hening Tuti , Zain Rosnah Binti
Published: February 2020

Background: Cigarette smoke contains various carcinogenic substances such as polycyclic aromatic hydrocarbons and nitrosamines. These chemicals not only have the potential to damage DNA, but can also induce genetic mutations and activate genes that function during apoptosis. Thus, if the gene is dysregulated, it will cause cells to survive, proliferate and subsequently lead to the development of cancerous ones. Histologically, the carcinogenic process affecting the oral cavity starts with hyperplasia and dysplasia, followed by severe dysplasia then leading to invasive cancer and metastatic processes in other bodies. Purpose: This study aims to reveal the correlation between exposure to cigarette smoke and the degree of epithelial dysplasia evident in research subjects. Methods: This study used 27 samples of Rattus norvegicus tongue, divided into three groups, namely; a control group, a treatment group subjected to four weeks’ exposure to cigarette smoke, and a treatment group subjected to exposure lasting eight weeks. Each rat was placed in an individual chamber and exposed to smoke from 20 cigarettes introduced by a pump via a pipe for 7.5 minutes. The degree of epithelial dysplasia in each case was subsequently observed microscopically using HE staining technique. Results: Mild epithelial dysplasia increased by 0.82%, during the fourth week of exposure to cigarette smoke and by 2.99% during the eighth week. Similarly, moderate epithelial dysplasia rose by 5.29% during the fourth week of exposure and 5.99% during the eighth week. Severe epithelial dysplasia also increased by 2.2% during the fourth week of exposure and by 2.66% during the eighth week. Conclusion: The longer the exposure to cigarette smoke, the higher the degree of ensuing dysplasia.
Perlindungan Hukum bagi Investor pada Transaksi Aset Kripto dalam Bursa Berjangka Komoditi
Authors: Puspasari Shabrina
Published: February 2020

Berkembangnya teknologi finansial mengeluarkan banyak inovasi khususnya pada produk inovasi investasi yaitu crypto asset. Perdagangan berjangka komoditi adalah sarana perdagangan yang dapat dimanfa’atkan agar masyarakat terhindar dari resiko cryptocurrency yang fluktuatif dan dapat menyebabkan penggelembungan harga. Namun dalam praktiknya, transaksi aset kripto tidak terlepas oleh resiko kerugian yang bisa dialami oleh Investor yang melakukan jual beli aset kripto dalam Bursa Berjangka. Resiko terkait tidak adanya underlying asset yang mendasari penerbitan aset dan dasar harga, serta tindak kriminal dalam internet seperti hacking dan scam yang bisa menyerang akun nasabah (investor) dimana hal tersebut sudah diluar tanggung jawab badan usaha aset kripto. Peraturan Bappebti yang baru dinilai masih kurang terhadap perlindungan hukum bagi para Investor terkait kerugian yang disebabkan oleh nasabah atau Investor lain secara individu. Penulisan skripsi ini diharapkan dapat mencari solusi bagi masalah yang dihadapi Investor dalam kegiatan perdagangan aset kripto di Bursa Berjangka.
Implementasi Kebijakan Eco-Investment Pada Sebagai Perwujudan Pelaksanaan Pembangunan Berkelanjutan Berbasis Teknologi dan Kesejahteraan
Authors: Wijaya Yudi Yasmin , Effendi Shofi Munawwir
Published: February 2020

Investasi merupakan suatu kegiatan yang tidak dapat dilepaskan dari tujuan atas kesejahteraan. Konsep akan kesejahteraan pada kegiatan ini bertumpu pada kegiatan yang berbasis profit. Namun, perlu diketahui bahwa profit merupakan suatu tumpuan yang penting namun bukan yang satu-satunya. Konsep akan kesejahteraan memiliki banyak kriteria lain yang tidak dapat diabaikan begitu saja, salah satunya adalah pemenuhan terhadap Hak Asasi Manusia (HAM). Pemenuhan terhadap HAM merupakan hal yang sangat penting untuk diwujudkan sebagai salah satu kriteria kesejahteraan suatu negara. Pemenuhan atas keadaan lingkungan yang baik bagi masyarakat merupakan suatu perwujudan yang tidak dapat dihindarkan, dimana kemudian pemenuhan tersebut memerlukan suatu langkah yang efektif. Munculnya berbagai pemikiran dan innovasi menciptakan suatu gagasan yang berguna untuk merealisasi suatu keadaan seimbang yang menguntungkan dan sekaligus berkelanjutan. Keadaan ini direalisasikan dengan suatu kegiatan yang disebut dengan ecoinvestment atau investasi berbasis lingkungan. Perwujudan aktivitas ini dapat dilakukan dengan mewujudkan sistem kebijakan yang terintegrasi pada suatu negara khususnya daerah kota sebagai pemegang hak otonomi. Sebagai suatu kegiatan dengan tujuan yang besar maka unsur atas dasar hukum diperlukan sebagai pondasi kebijakan yang bersifat normatif. Penerapan atas eco-investment serta aturan perundang-undangan yang mengaturnya sangat diperlukan bagi Negara Indonesia. Sebagai negara yang bertujuan untuk memajukan teknologi atas investasi sekaligus pembangunan berkelanjutan yang efektif, maka kegiatan ini dapat menjadi salah satu solusi terbaik atas perwujudan kesejahteraan dan sebagai salah satu bentuk pemenuhan HAM.
Drug and Vaccine Design against Novel Coronavirus (2019-nCoV) Spike Protein through Computational Approach
Authors: Kumar Suresh
Published: February 2020

The recent outbreak of the new virus in Wuhan city, China from the sea food market has led to the identification of a new strain called the corona virus and named as novel corona virus (2019-nCoV) belonging to Coronaviridae family. This has created major havoc and concern due to the mortality of 250 persons and affecting more than 10,000 people. This virus causes sudden fever, pneumonia and also kidney failure. In this study a computational approach is proposed for drug and vaccine design. The spike protein sequences were collected from a protein database and analysed with various bioinformatics tools to identify suitable natural inhibitors for the N-terminal receptor binding domain of spike protein. Also, it is attempted to identify suitable vaccine candidates by identifying B-Cell and T-cell epitopes. In the drug design, the tanshinone Iia and methyl Tanshinonate were identified as natural inhibitors based on the docking score. In the vaccine design, B-cell epitope VLLPLVSSQCVNLTTRTQLPPAYTN was found to have the highest antigenicity. FVFLVLLPL of MHC class-I allele and FVFLVLLPL of MHC class-II allele were identified as best peptides based on a number of alleles and antigencity scores. The present study identifies natural inhibitors and putative antigenic epitopes which may be useful as effective drug and vaccine candidates for the eradication of novel corona virus.
PENGARUH LITERASI KEUANGAN KECERDASAN SPIRITUAL DAN PENDIDIKAN KEUANGAN DI KELUARGA TERHADAP PENGELOLAAN KEUANGAN MAHASISWA
Authors: Sigo Madelberta Resma Nugraheni , Hariani Lilik Sri , Walipah Walipah
Published: February 2020

This study aims to analyze the effect of financial literacy, spiritual intelligence, and financial education in families on the financial management of students of Economic Education in Kanjuruhan University Malang. This type of research uses quantitative research, using multiple linear regression. The population in this study were all students of Economic Education at Kanjuruhan University Malang, totaling 198 students with a research sample of 65 students. The sampling technique in this study used quota sampling. The data obtained were analyzed using the SPSS application version 16.00 for windows. Based on the results of the analysis it is known that there is a significant simultaneous and partial effect between financial literacy, spiritual intelligence, and financial education in families on the financial management of students of Economic Education at Universitas Kanjuruhan Malang.
PENGARUH PREFERENSI RESIKO, LITERASI EKONOMI, PENGETAHUAN GALERI INVESTASI TERHADAP MINAT INVESTASI MAHASISWA FAKULTAS EKONOMIKA DAN BISNIS
Authors: Gesta Rine , Andayani Endah , Al Arsy Auliana Farrabanie
Published: February 2020

This study aims to determine the effect of Risk Preference, Economic literacy and Investment Gallery on the investment interests of Economics and Business Faculty students. (This type of research uses quantitative research methods using multiple linear regression. The population in this study were students of the 2015 Kanjuruhan Malang Faculty of Economics and Business, amounting to 412 people. with a research sample of 25% of the population of 103 students. The data obtained was analyzed with the help of SPSS version 22.00 for Windows. Based on the calculation results, it is known that: (1) There is an influence of Risk Preference, Economic literacy and Investment Gallery on the investment interest of Economics and Business Faculty students. (2) There is no Risk Preference Effect on investment interest in Economics and Business Faculty students. (3) There is an Influence of Economic Literacy on the investment interest of the Economics and Business Faculty students (4) There is an Investment Gallery Effect on the investment interest of the Economics and Business Faculty students. The results of multiple linear regression analysis showed that the F value of 24.771 with a significance level of 0.000 <0.05, it can be said that Risk Preference (X1), Economic Literacy (X2), and Knowledge of Investment Gallery (X3) have simultaneous or joint effects. equal to Investment Interest (Y).
Pengaruh pengencer dan lama simpan semen Ayam kampung pada suhu ruang terhadap Motilitas dan viabilitas spermatozoa
Authors: Ulus Egidius , Kusumawati Enike Dwi , Krisnaningsih Aju Tjatur Nugroho
Published: February 2020

Abstract

The study was conducted from February to April 2018 in the field laboratory and integrated laboratory of University Kanjuruhan Malang. The purpose of this research is to know the effect of diluent and timetorage of kampung chicken sperm at room temperature to motility and viability of spermatozoa. The diluent used was NaCl, egg yolk tris aminomethane and no diluent with sperm duration of 0, 3, 6, 9, 12, 15, 18, 21, 24, 27, 30 hours and 10 replications. This research method is experimental laboratory by using completely randomize design of factorial.  The data obtained in the study will be analyzed using the method of analysis of variance. The results showed that there was no significant effect (P> 0,05) of diluent, time storage as well as interaction between diluent and time storage to sperm motility and viability. Diluent and time storage which still maintain motility up to the minimum limit for AI was NaCl in 18 hours (41,5%), egg yolk tris aminomethan and without diluent at 12 hours of time storage that was equal to 49% and 42%. While the diluent and the time store that still can maintain viability up to the minimum limit for AI was NaCl and egg yolk tris aminomethan on the 18-hour (82.5%), without diluent on the time storage 12 hours (81.5%). It can be concluded that the optimum spermatozoa motility on NaCl diluent with 6 hours of time storage. While the optimum viability of the NaCl and egg yolk tris aminomethan on the time storage 18 hours.
Silicone tape versus micropore tape to prevent medical adhesive-related skin injuries: systematic review and meta-analysis
Authors: Santos André , Terra Aline , Nogueira José Luiz , Noronha Kenya , Marcatto Juliana , Andrade Mônica
Published: February 2020

Objective: This study aims to compare the efficacy and safety of silicone tapes compared to microporous tapes in patients with fragile skin. Methods: A systematic review of the scientific literature was carried out. Clinical trials that compared silicone tape for medical use with the microporous tape in preterm newborns, newborns, children, elders, or people with increased risk of MARSI were included. This report followed the principles of the PRISMA statement. Results: Three randomized controlled trials were included. The silicone tape was associated with fewer injuries (RR = 0.53; p-value = 0.03), but no difference was found in terms of prevention of moderate or severe injuries (RR = 0.25; p-value = 0.20). Silicone tapes produce significantly less edema/erythema response than microporous tapes in children (MD = -0.42; p-value < 0.0001). The quality of evidence was considered very low. Conclusion: The evidence suggests that silicone tapes may be gentler to patients’ skin than microporous tapes. However, no study reported data on the outcomes of interest. The studies have small samples, a short time horizon, and the quality of evidence was considered very low. There is insufficient information to allow the recommendation of silicone tapes to prevent skin injuries compared to microporous tapes.
Dados de mundo real no processo de tomada de decisão: uma análise sob a perspectiva do sistema brasileiro de saúde suplementar
Authors: Ballalai André , Souza Nadja , Silva Janay , Suavinha Marina , Sousa Cláudia , Decimoni Tassia Cristina
Published: February 2020

O debate sobre a necessidade de melhoria da utilização de recursos em saúde fez aumentar o interesse em evidências do mundo real (EMR) nos últimos anos. No sétimo congresso Latino-Americano da Sociedade Internacional de Farmacoeconomia e Pesquisa de Desfechos, diferentes palestrantes exploraram como o manejo desses dados pode auxiliar no processo de tomada de decisão. Quatro membros representando diferentes segmentos do Sistema de Saúde Suplementar (SSS) brasileiro foram convidados a participar de um painel de especialistas, a fim de entender suas percepções sobre o assunto. O nível de confiança na informação atualmente disponível variou entre 70% e 90% e os dados são utilizados na rotina de tomada de decisão. Considerando a utilização de evidências para prever decisões, os especialistas relatam não existir uma matriz institucional, mas que as informações existentes são utilizadas na construção de modelos preditivos por meio da criação de pacotes de serviços. A priorização da tomada de decisão é hoje essencialmente baseada em estimativas de custos. Apesar disso, são observadas diferentes situações em que dados de mundo real podem balizar esse processo. Existiu consenso de que uma mudança de paradigmas está ocorrendo e que esses processos representam um futuro plausível. O uso de EMR é de grande importância no processo de tomada de decisão na perspectiva do SSS e, acima de tudo, no suporte de modelos de saúde baseados em valor, sendo recomendado pela Agência Nacional de Saúde Suplementar como um pilar estratégico para a sustentabilidade do sistema.
Aspiration-Sclerotherapy Versus Laparoscopic De-roofing in the Treatment of Renal Cysts: Which is better?
Authors: Zhang Xueling , Cao Dehong , Han Peizhen , Ren Zhengju , Wang Jia , Wei Qiang
Published: February 2020

Purpose: To compare the clinical efficiency between aspiration-sclerotherapy (AS) and laparoscopic de-roofing (LD) in the management of renal cysts through meta-analysis of comparative studies. Method: A comprehensive literature search was performed by PubMed, MEDLINE, Ovid and Web of Science for relevant studies published up to January 2020. The statistical analyses were conducted with Review Manager 5.3.0 and Stata 15.1. The sensitivity analysis was also carried out to confirm the reliability of this Meta-analysis. Results: Our searches of literature generated 6 studies (1547 patients incorporated) comparing AS with LD in the impacts of renal cyst therapy. Of these, 6 studies contained 1106 and 441 patients who were treated with AS and LD, respectively. The outcome of this meta-analysis indicated that LD group was superior in symptomatic successful rate [Odds Ratio(OR): 0.28; 95%Confidence Interval(CI): 0.09 to 0.86；P=0.03), radiological successful rate (OR: 0.06; 95%CI: 0.02 to 0.15; P<0.01) and recurrence rate (OR: 6.08; 95%CI: 2.81 to 13.15; p<0.01). Nevertheless, AS group had shorter treatment time [Mean Difference(MD)：-51.10; 95% CI：-73.01 to -29.20; p<0.01]. No statistically significant difference was showed in the rate of complications (OR: 3.19; 95% CI: 0.39 to 25.88; P=0.28). Conclusion: In our meta-analysis, LD had higher symptomatic successful rate, radiological successful rate as well as lower recurrence rate than AS, while the treatment time was longer.
Self-Analysis of Repeat Proteins Reveals Evolutionarily Conserved Patterns
Authors: Merski Matthew , Młynarczyk Krzysztof , Ludwiczak Jan , Skrzeczkowski Jakub , Dunin-Horkawicz Stanisław , Górna Maria W.
Published: February 2020

Background Protein repeats can confound sequence analyses because the repetitiveness of their amino acid sequences lead to difficulties in identifying whether similar repeats are due to convergent or divergent evolution. We noted that the patterns derived from traditional “dot plot” protein sequence self-similarity analysis tended to be conserved in sets of related repeat proteins and this conservation could be quantitated using a Jaccard metric. Results Comparison of these dot plots obviated the issues due to sequence similarity for analysis of repeat proteins. A high Jaccard similarity score was suggestive of a conserved relationship between closely related repeat proteins. The dot plot patterns decay quickly in the absence of selective pressure with an expected loss of 50% of Jaccard similarity due to a loss of 8.2 % sequence identity. We assembled a standard set of 79 repeat proteins representing all the subgroups in RepeatsDB to perform method testing on. Comparison of known repeat and non-repeat proteins from the PDB suggested that the information content in dot plots could be used to identify repeat proteins from pure sequence without needing structural information. Analysis of the UniRef90 database suggested that 16.9% of all known proteins could be classified as repeat proteins. These 13.3 million putative repeat protein chains were clustered and a significant amount (82.9%) of clusters containing between 5 and 200 members were of a single functional type. Conclusions Dot plot analysis of repeat proteins attempts to obviate issues that arise due to the sequence degeneracy of repeat proteins. These results show that this kind of analysis can efficiently be applied to analyze repeat proteins on a large scale.
Storage time and temperature affect the isolation rate of Mannheimia haemolytica and Pasteurella multocida from bovine bronchoalveolar lavage samples
Authors: Driessche Laura Van , De Neve Charlotte , Haesebrouck Freddy , Leenen Katharina van , Boyen Filip , Pardon Bart
Published: February 2020

Background: A microbiological diagnosis is essential to better target antimicrobial treatment, control and prevention of respiratory tract infections in cattle. Under field conditions, non-endoscopic broncho-alveolar lavage (nBAL) samples are increasingly collected. To what extent the highly variable turnaround time and storage temperatures between sampling and cultivation affect the isolation rate of bacterial pathogens is unknown. Therefore, the objective of this experimental study was to determine the effect of different storage temperatures (0°C, 8°C, 23°C and 36°C) and times (0,2,4,6,8,24,48 hours) on the isolation rate and concentration of Pasteurellaceae in nBAL samples from clinically affected animals. Results: At a storage temperature temperature of 36°C isolation rates of Mannheimia haemolytica and Pasteurella multocida were significantly reduced 6h and 48h after sampling, respectively. At room temperature (23°C), a decrease in M. haemolytica and P. multocida isolation rate was noticed, starting at 24 and 48 hours after sampling, respectively, but only significant for P. multocida at 48h. The presence of microbial contamination negatively affected the isolation of P. multocida in clinical nBAL samples, but not of M. haemolytica. Conclusion: Optimal M. haemolytica and P. multocida isolation rates from clinical nBAL samples are obtained after storage at 0°C or 8°C, provided that the sample is cultivated within 24 hours after sampling. The maximum period a sample can be stored without an effect on the M. haemolytica and P. multocida isolation success varies and is dependent on the storage temperature and the degree of microbial contamination.
Neuropathological changes in dorsal root ganglia induced by pyridoxine in dogs
Authors: Yun Sumin , Kim Woosuk , Kang Min Soo , Kim Tae Hyeong , Kim Yoonhwan , Ahn Jin-Ok , Choi Jung Hoon , Hwang In Koo , Chung Jinyoung
Published: February 2020

Background: Pyridoxine (PDX), vitamin B6, is an essential vitamin. PDX deficiency induces various symptoms and abuse of PDX supplement also acts as a neurotoxicant that induces severe sensory neuropathy. Results: To assess the possibility of reversible sensory neuropathy model using dogs, 150 mg/kg pyridoxine (PDX) was injected subcutaneously into dogs for seven days and body weight measurement, postural reaction assessments, and electrophysiological recordings were conducted. In addition, the morphology of dorsal root ganglia (DRG) and changes of glial fibrillary acidic protein (GFAP) immunoreactive satellite glial cells and ionized calcium-binding adapter molecule 1 (Iba-1) immunoreactive microglia/macrophages were observed at 0, 1 and 4 weeks after the last PDX treatment. During the administration period, body weight loss and proprioceptive loss occurred. After the treatments were completed, electrophysiological recordings showed that the H-reflex of the treated dogs had disappeared at week 0. These phenomena persisted for four weeks exceptional body weight. CV and HE staining revealed that neurons in DRG had significant loss of large-sized neurons 0 and 1 week, but these neurons were recovered 4 weeks. Iba-1 and GFAP immunohistochemistry showed that reactive microglia/macrophages and satellite glial cells were pronounced at 0 and 1 weeks after the last PDX treatment, respectively and thereafter decreased with time after PDX treatment, respectively.Conclusions: This result suggests that PDX-induced neuropathy model is reversible and can be a good experimental model for research on neuropathy in dogs.
The Geriatric Nutrition Risk Index versus the Mini-Nutritional Assessment Short Form in predicting postoperative delirium and hospital length of stay among older non-cardiac surgical patients: a prospective cohort study
Authors: Zhao Yanli , Ge Ning , Xie Dongmei , Gao Langli , Wang Yanyan , Liao Yulin , Yue Jirong
Published: February 2020

Backgrounds : Malnutrition has been shown to be associated with poor prognosis in older surgical patients. Several tools are available for detecting malnutrition. But little is known about their ability to assess risks of postoperative adverse outcomes. The study aimed to compare the ability of the Geriatric Nutritional Risk Index (GNRI) and the Mini-Nutritional Assessment Short Form (MNA-SF) in predicting postoperative delirium (POD) and length of stay (LOS) among older non-cardiac surgical patients.
Methods : Prospective study of 288 older non-cardiac surgical patients from the West China Hospital of Sichuan University. Preoperative nutritional status was assessed using the GNRI and MNA-SF, and patients were followed for the occurrence of POD and LOS. Multivariable logistic regression and linear regression analyses were used to identify predictors of these outcomes. The relative performance of the GNRI and MNA-SF as predictors of these outcomes were determined by Receiver Operating Characteristic curves (ROC) analyses and the area under the curve (AUC) .
Results : Multivariable analysis revealed that preoperative malnutrition by the MNA-SF was significantly associated with POD. Linear regression analysis showed that preoperative low/high nutritional risk of the GNRI and malnutrition by the MNA-SF were independent predictors of prolonged LOS. Moreover, the area under the curve (AUC) of MNA-SF scores for POD was better than GNRI scores (AUC=0.718, 95%CI: 0.64-0.80, P <0.001 vs AUC=0.606, 95%CI: 0.52-0.69, P= 0.019; Delong’s test, P=0.006), but the AUC of GNRI scores and MNA-SF scores have no significant difference when predicting prolonged LOS (AUC=0.611, 95%CI: 0.54-0.69, P= 0.006 vs AUC=0.533, 95%CI: 0.45-0.62, P= 0.421; Delong’s test, P=0.079).
Conclusion : The MNA-SF was more effective than the GNRI at predicting the development of POD, but the two nutrition screening methods have similar performance in predicting prolonged LOS among older non-cardiac surgical patients.
Relationships of Accelerometer-based Measured Objective Physical Activity and Sedentary Behaviour with Cognitive Function: A Comparative Cross-sectional Study of China’s Elderly Population
Authors: Wu Zhi jian , Wang Zhu ying , Hu Bing qian , Zhang Xu hui , Zhang Fan , Wang Hou lei , Li Fang hui
Published: February 2020

This study explored the effects of physical activity and sedentary behaviour on the decline of cognitive ability among the elderly. To compensate for the limitations of self-reported physical activity, objective measures were used. A cross-sectional survey of 308 aged people mean 68.66±5.377 years, in Nanjing, China, was conducted. Physical activity was measured using the ActiGraph GT3X+, and cognitive function was measured using the Montreal Cognitive Assessment. The overall participant model, adjusted for age, BMI, education, and monthly average income, found that light physical activity (β=0.006, p<0.01), moderate-vigorous physical activity (β=0.068, p<0.001), and total physical activity (β=0.006, p<0.01) had a significant linear relationship with cognitive ability, while sedentary time did not (β=-0.020, p＞0.05). Further, light physical activity only affects the cognitive ability of elderly females (β=0.006, p<0.05). There was an inverted ‘U’ association between moderate-vigorous physical activity and cognitive ability. The association models found that moderate-vigorous physical activity in the 22.13 min·day –1 ～38.79 min·day –1 range affected cognitive ability most beneficially, with the highest beta coefficient among all groups (β=0.091, p<0.05). In conclusion, while physical activity can significantly improve cognitive ability among the elderly, sedentary behaviour is associated with decreased cognitive function across genders.
Prognostic significance of SDF-1 in colorectal cancer depends on CD8+ T-cell density
Authors: Lalos Alexandros , Tülek Ali , Tosti Nadia , Mechera Robert , Wilhelm Alexander , Soysal Savas , Daester Silvio , Kancherla Venkatesh , Weixler Benjamin , Spagnoli Giulio C. , Eppenberger-Castori Serenella , Terracciano Luigi , Piscuoglio Salvatore , Flüe Markus von , Posabella Alberto , Droeser Raoul
Published: February 2020

Background: Since colorectal cancer (CRC) remains one of the most common malignancies, a tremendous amount of studies keep taking place in this field. Over the past 25 years, a notable part of the scientific community has focused on the association between the immune system and colorectal cancer. A variety of studies have shown that high densities of infiltrating CD8+ T cells are associated with improved disease-free and overall survival in colorectal cancer (CRC). Stromal cell-derived factor-1 (SDF-1) is a protein that regulates leukocyte trafficking and is variably expressed in several healthy and malignant tissues. There is strong evidence that SDF-1 has a negative prognostic impact on colorectal cancer (CRC). However, based on a significant correlation of SDF-1 and CD8+ T cells in a previous study (r=0.53, p<0.0001), we hypothesized that the prognostic significance of SDF-1 in CRC could depend on the immune microenvironment. Therefore, we explored the combined prognostic significance of SDF-1 expression and CD8+ T cell density in a large CRC collective. Methods: We analyzed a tissue microarray (TMA) of 613 patient specimens of primary CRCs by immunohistochemistry (IHC) for the expression of SDF-1 by tumor cells and tumor-infiltrating immune cells (TICs) and CD8+ T-cells. Besides, we analyzed the expression of SDF-1 at the RNA level in The Cancer Genome Atlas cohort (TCGA). Results: We found that the the combined high expression of SDF-1 and CD8+ T-cell infiltration shows a favorable 5-year overall survival rate (66%; 95%CI=48–79%) compared to tumors showing a high expression of CD8+ T-cells only (55%; 95%CI=45–64%; p=0.0004). High expression of SDF-1 and CD8+ T-cells infiltration was significantly associated with a favorable prognosis also in a validation group (p=0.016). Univariate and multivariate Hazard Cox regression survival analysis considering the combination of both markers revealed that the combined high expression of SDF-1 and CD8+ T cells was an independent, favorable, prognostic marker for overall survival (HR=0.34, 95%CI=0.17–0.66; p=0.002 and HR=0.45, 95%CI=0.23–0.89; p=0.021, respectively). In a spearman’s correlation analysis from the TCGA cohort, SDF-1 also correlated significantly with CD8+ T cells (r=0.28). Conclusions: SDF-1 high /CD8 high density represents an independent, favorable, prognostic condition in CRC, most likely due to an effective antigen-specific immune response.
Anti-SARS and anti-HCV drugs repurposing against the Papain-like protease of the newly emerged coronavirus (2019-nCoV)
Authors: Elfiky Abdo , Ibrahim Noha S
Published: February 2020

A new mysterious coronavirus outbreak started last month in China. The World Health Organization (WHO) termed the new virus strain 2019-nCoV to be the seventh reported human coronaviruses (HCoV). A seafood market in Wuhan city, central China was the starting point of the emergence with unknown animal causes the first animal to human infection. Until today 904 confirmed deaths and more than 40000 cases confirmed in China and 28 countries. There is a massive fear of the human to human transmission of 2019-nCoV that reported last week by the Chinese government. The most famous two strains of HCoV are the Severe Acute Respiratory Syndrome coronavirus (SARS CoV) and the Middle East Respiratory Syndrome coronavirus (MERS CoV). The former had emerged in China in 2002 while the latter emerged in the Middle East region in 2012 and south Korea in 2015. In this study, the newly emerged 2019-nCoV papain-like protease (PLpro) is targeted by anti-SARS PLpro drugs and the anti-Hepatitis C Virus (HCV) Non-structural protein 3 (NS3) serine protease drugs. Sequence analysis, modeling, and docking are used to get a valid model for 2019-nCoV PLpro. The results suggest the effectiveness of the anti-SARS drugs (GRL-0667, GRL-0617, and Mycophenolic acid) and the anti-HCV drugs (Grazoprevir, Telaprevir, and Boceprevir) as potent inhibitors against the newly emerged coronavirus.
Basic Criteria, Models, and Indicators of Intersectoral Collaboration in Health Promotion: A Scoping Study
Authors: Author) noora rafiee(Former Corresponding , Damari Behzad , Hajebi Ahmad , Goudarzi reza , Author) Mohammad Reza Amir Esmaili(New Corresponding , Haghshenas Abbas
Published: February 2020

Background: The healthcare sector has a small share in community health, and other sectors are actively involved in this domain. Therefore, only by a collective and collaborative action can health promotion interventions be properly implemented. In order to have intersectoral collaboration in the domain of healthcare, basic criteria are required as an operational guide for the successful implementation of such collaborations. A specific framework is also required so that the programs can be properly implemented accordingly. After the implementation, the success or failure of the collaborative action will be determined by assessing the effectiveness of the actions taken using an appropriate assessment system (e.g., indicators). In this study, the basic criteria, models, and indicators of intersectoral collaboration in health promotion were investigated to facilitate the implementation of collaboration. Methods: This scoping review was conducted using datasets of Embase, Web of Science, Scopus, and PubMed, and search engines of Google, Google Scholar, and ProQuest. Original articles, review articles, and reports were included in this study. In terms of subject, articles which referred to the basic criteria, models, or indicators of intersectoral collaboration in health promotion were included. Results: A total of 52 studies were included in the final analysis, and 32 codes in three categories (micro, meso, and macro) were obtained. Micro-level intersectoral collaboration criteria had the highest frequency. Among the models used in the reviewed studies, social network analysis (SNA), Diagnosis of Sustainable Collaboration (DISC), Bergen, and logic models had the highest frequency in health promotion. Among the indicators studied, the number of participants and the level of collaboration as well as its sustainability were the most frequent indicators. Conclusion: The findings identified the most important and widely used criteria, models, and indicators of intersectoral collaboration in health promotion which can be useful for decision-makers and planners in the domain of health promotion, in designing, implementing, and evaluating collaborative programs.
Hepatitis B Virus Can Be Sensed by STING-dependent DNA Sensors but Suppresses the DNA Sensing Pathway in Humans with Acute and Chronic Hepatitis B Virus Infection
Authors: Chen Hongtao , He Guirong , Chen Yue , Zhang Xiaoyong
Published: February 2020

Background : With the discovery of stimulator of interferon genes (STING) in 2008, many intracellular molecules have been identified as STING-dependent DNA sensors in recent years. Studies show the DNA sensor-STING-IFN-β pathway plays an important role in defense against viral infections. However, the recognition of hepatitis B virus (HBV) by DNA sensors is still largely unclear. In this study, we aimed to investigate the role of STING-dependent DNA sensors in HBV infection.
Methods: The expression of these DNA sensors in PBMCs from patients with acute and chronic HBV infection was analyzed by quantitative real-time PCR. The cellular source of the upregulated DNA sensor and the response of the corresponding sensing pathway in PBMCs from HBV-infected patients were also investigated.
Results: The expression of interferon gamma inducible protein 16 (IFI16), DEAD-box polypeptide 41 (DDX41), meiotic recombination 11 homolog A (MRE11), and STING were upregulated in chronic HBV-infected patients, whereas only IFI16 expression increased in acute HBV-infected patients. However, no IFN-β induction was observed in PBMCs in either acute or chronic HBV-infected patients. We next found IFI16 was mainly expressed in monocytes from acute and chronic hepatitis B patients. By stimulation of monocytes with VACV ds 70mer, an agonist ligand for IFI16, we confirmed the suppressed response of the IFI16-STING pathway in chronic HBV infection.
Conclusions: Our results suggest that HBV can be sensed by DNA sensors in PBMCs in both acute and chronic HBV-infected patients and meanwhile actively counteract the DNA sensing pathway in PBMCs, which may facilitate the persistence of HBV infection.
WITHDRAWN: A Double Blind Randomized Clinical Trail: Comparing Lactobacillus plantarum 299v with Placebo in treating irritable bowel syndrome patients
Authors: haq Moeen-ul- , Ullah Fazl , Hassan Muhammad Kamran , Babar Ahmad Nawaz , Ullah Anwar
Published: February 2020

Irritable bowel syndrome (IBS) is a gastrointestinal disease of intestinal mobility. IBS present with variable clinical symptoms making the treatment difficult. IBS is quiet prevalent around the globe with different frequency. Differences in frequency and gender is due to diet habit. It is less frequent where diary product and vegetable are frequently consumed as compared to those who consumed meat. Lactobacillus plantarum 299v (L. plantarum 299v) is the most widely studied strain in the IBS patients. It is resistant to the actions of intestinal acids and bile, colonizes the human colonic mucosa and is non-pathogenic in nature. The efficacy of Lactobacillus plantarum 299v L is different in different study. The present study was designed to find the efficacy of Lactobacillus plantarum 299v in comparison to placebo in randomized control trial. MethodOne hundred and ninety patients were assessed for eligibility 46 among them were excluded from the study and twenty four declined to participate in the study. One hundred and twenty patient of IBS was grouped in two different groups. The one was treated with Lactobacillus plantarum 299v and the other was treated with placebo. Symptoms of IBS, like abdominal pain, bloating and complete rectal emptying was noted and interpreted among the groups. Results There was no statistically significant difference in relieving abdominal pain, bloating, rectal emptying in Lactobacillus plantarum 299v treated group and placebo treated group. Conclusion This randomized control trail of Lactobacillus plantarum 299v fail to show signicant efficacy in IBS treatment as compared to placebo.
Strategi Kemitraan Penyelenggaraan Parenting Bagi Orang Tua di Lembaga PAUD Kecamatan Bumiayu Kabupaten Brebes
Authors: Wiyani Novan Ardy
Published: February 2020

The purpose of this community service is to provide knowledge both theoretically and practically related to child education methodology (pedagogy). Community service activities using andragogy approach and counseling methods. There are four results achieved from this activity. First, participants gain knowledge about the position of parents in educating children based on the characteristics of children and gain knowledge about positive relationships between fathers and mothers in the process of educating children in the family environment. Second, parents already have strong reasons that make them have to prioritize children's education from an early age. Third, parents have the assumption that habituation activities undertaken to shape the character of children in PAUD institutions must be accompanied by habituation activities carried out in the family environment. Fourth, parents are able to identify the level of addiction to the use of gadgets on themselves and get knowledge about 10 ways to discipline the use of gadgets in children.

 

Tujuan dari pengabdian masyarakat ini adalah untuk memberikan pengetahuan baik secara teoritis maupun praktis terkait dengan metodologi pendidikan anak (pedagogi). Kegiatan layanan masyarakat menggunakan pendekatan andragogi dan metode konseling. Ada empat hasil yang dicapai dari kegiatan ini. Pertama, peserta mendapatkan pengetahuan tentang posisi orang tua dalam mendidik anak berdasarkan karakteristik anak dan mendapatkan pengetahuan tentang hubungan positif antara ayah dan ibu dalam proses mendidik anak di lingkungan keluarga. Kedua, orang tua sudah memiliki alasan kuat yang membuat mereka harus memprioritaskan pendidikan anak sejak usia dini. Ketiga, orang tua memiliki asumsi bahwa kegiatan pembiasaan yang dilakukan untuk membentuk karakter anak-anak di lembaga PAUD harus disertai dengan kegiatan pembiasaan yang dilakukan di lingkungan keluarga. Keempat, orang tua dapat mengidentifikasi tingkat kecanduan penggunaan gadget pada diri mereka sendiri dan mendapatkan pengetahuan tentang 10 cara untuk mendisiplinkan penggunaan gadget pada anak-anak.
Penguatan Desain Dakwah Masjid di Era Milenilal melalui Android
Authors: Jasuri Jasuri , Khalif M. Ardhi , Anwar Edi Daenuri
Published: February 2020

Dedication work with the title "Design Da'wah Mosque in Millennial Era through Android" uses a community based research (CBR) model, namely by providing assistance in making mosque website design, website management and website content management in eight mosques in Central Java. The meeting point of da'wah that is carried out in the mosque either through recitation, or other forms of activity can be well documented via the internet and can be accessed by Muslims at large. The need for revitalization of the Da'wah Mosque Strategy, revitalization in question is the Da'wah Mosque Strategy is carried out massively, recorded, and uploaded on the mosque website. By uploading it on the website of the mosque, all people in need can download study materials and can see / listen at any time. Of the eight mosques, only two mosques have websites, the Baiturahman Mosque in Semarang and M asjid Agung in Central Java. This assistance resulted in a pretty good design. The website that has been designed by the mosque admin is good with menus and wicets relating to the activities of the mosque preaching. The mosque website is filtered in one "dakwah online" application. Users can enjoy the da'wah of the mosques from the eight mosques in real time effectively and efficiently.

 

Pengabdian dengan topik “Desain Dakwah Masjid di Era Milenial melalui  Android” ini menggunakan model community based research (CBR), yaitu dengan melakukan  pendampingan pembuatan desain website masjid, pengelolaan website dan manajemen konten website pada delapan masjid di Jawa Tengah. Titik temu dakwah yang dilaksanakan di masjid baik melalui pengajian, maupun bentuk-bentuk kegiatan yang lain bisa didokumentasi dengan baik melalui internet dan dapat diakses oleh umat islam secara luas. Perlu adanya revitalisasi Strategi dakwah masjid, revitalisasi yang dimaksud adalah Strategi dakwah masjid dilakukan secara masif, terdata, dan diunggah dalam website masjid. Dengan diunggah dalam website masjid maka semua masyarakat yang membutuhkan bisa mendownload bahan-bahan pengajian dan bisa melihat/mendengarkan setiap saat. Dari delapan masjid dimaksud hanya dua masjid yang sudah memiliki website yaitu Masjid Baiturahman Semarang dan Masjid Agung Jawa Tengah. Pendampingan ini menghasilkan desain yang cukup baik. Website yang telah di desain oleh admin masjid sudah baik dengan menu dan wicget yang berkaitan dengan kegiatan-kegiatan dakwah masjid. Website masjid tersebut tersharing dalam satu aplikasi “dakwah online”. User bisa memenikmati dakwah masjid dari delapan masjid tersebut secara realtime dengan efektif dan efisien.
Plant-wide modelling in wastewater treatment: showcasing experiences using the Biological Nutrient Removal Model
Authors: Seco A. , Ruano M. V. , Ruiz-Martinez A. , Robles A. , Barat R. , Serralta J. , Ferrer J.
Published: February 2020

Plant-wide modelling can be considered an appropriate approach to represent the current complexity in water resource recovery facilities, reproducing all known phenomena in the different process units. Nonetheless, novel processes and new treatment schemes are still being developed and need to be fully incorporated in these models. This work presents a short chronological overview of some of the most relevant plant-wide models for wastewater treatment, as well as the authors' experience in plant-wide modelling using the general model BNRM (Biological Nutrient Removal Model), illustrating the key role of general models (also known as supermodels) in the field of wastewater treatment, both for engineering and research.
Influence of archaeological discoveries in Novgorod on ideas about the origin of the Old Russian state.
Authors: Shishchenko Ekaterina Vital'evna
Published: February 2020

In the article, the author examines the main theories of the Genesis of the Eastern Slavs state and the role in their formation, updating and popularization of a number of historical sources of material, visual, as well as written (narrative) and other types found during archaeological work in one of the largest and oldest cities of Russia – Novgorod.
SETTLEMENTS’ ASPECT OF THE STRATEGY OF SPATIAL DEVELOPMENT FOR RUSSIA
Authors: Bukhvald E. M. , Kol`chugina A. V.
Published: February 2020

Strategizing the spatial development of the Russian Federation is an extremely complex, multifaceted task, which affects not only the traditional problem of the location of productive forces, but also a wide range of issues, concerning the ratio of different types of settlements, agglomeration processes, strengthening the role of each type of settlements and agglomerations in ensuring sustainable socio-economic development of the country and its regions. The active discussion around the dilemma “mega-cities and/or small and medium-sized cities”, which actively unfolded during the discussion of the draft of the spatial development Strategy, naturally didn’t lead to the formation of a mono polar position on this issue. Formally, newly adopted document paid tribute to the leading role of mega cities and large agglomerations in the development of the country’s economy and its modernization on the innovative basis, but also proceeds from the fact that the implementation of this trend of socio-economic development should not lead to the launch of the bulk of small settlements. This situation gives the reason to presume that many questions of the spatial development of the Russian economy haven’t yet received an adequate answer. This, in particular, concerns the settlement aspect of spatial Strategy. In addition, it is not clear what should be the program-target tools of the Spatial development strategy of the Russian Federation and what role national projects can play in this sphere.
THE BUDGET PROCESS AND INTER-BUDGET RELATIONS IN MODERN RUSSIA
Authors: Morozov O. V.
Published: February 2020

Questions of the organization of the budget process, relate not only to the ergonomics of the budget process, they go back to the problem of reproduction of state solvency. Meanwhile, the dependence of the state’s solvency on its efficiency, which, in turn, is a function of budget policy and features of decision-making on the use of public Finance, is not yet fully realized. The role and place of strategic planning documents in the budget policy, their relationship with the basic laws that directly affect the budget and tax, debt policy, financial relations of the Federal budget withthe budgets of the subjects of the Russian Federation, local budgets need to be clarified. It is not clear what role national projects should play in budget policy and how they should be reflected in the budget pr oces s. In the study of the chain links of such dependencies the author uses an extraordinary approach. Evaluation of the effectiveness of the budget process is carried out not by means of financial and economic indicators, the main parametersof the budget system, but based on the goals, objectives and expected results of budget policy. The principles of transparency and stability of the budget process, understood asquite applied and «counting» parameters, are proposed as the basis of the study. The criteria for evaluating the conditions of efficiency of formation, consideration, execution and control of budget decisions are introduced. As the results of the study, the author characterizes the tasks and tools to optimize the Federal budget process.