bluuebunny/crossref_metadata_2025 huggingface dataset:
ГРОМАДЯНСЬКЕ СУСПІЛЬСТВО & ЕКОЛОГІЧНА ПОЛІТИКА: ДІАЛЕКТИКА ВЗАЄМОЗВ’ЯЗКУ
Authors: Калюжна Ю. І.
Published: March 2024

Автором статті, на підставі осмислення концепту громадянського суспільства
та вивчення досвіду й практик західних демократій у вирішенні екологічної
проблематики, обґрунтовується теза про діалектику взаємозв’язку між ефективним функціонуванням громадянського суспільства та його інститутів й екологічною політикою держави. В статті запропоновано твердження – розвинене громадянське суспільство, завдяки активній політичній та соціальній участі громадян, громадянському контролю за діяльністю органів державної та регіональної влади, уваги громадян до захисту своїх прав і свобод, громадянській відповідальності щодо майбутнього наступних поколінь, фактично, – виконує магістральну функцію на шляху до створення
результативної екологічної політики держави. Автором відзначається, розвинене громадянське суспільство у політичній практиці країн сталої демократії, із урахуванням конкретних історичних, політичних, соціально-економічних і культурних умов, виступає в якості сприятливого соціального середовища та політичного підґрунтя для вирішення екологічної проблематики. Наголошується, що саме розвинене громадянське суспільство
та ефективна робота його інститутів є ключем до розв’язання екологічної
проблематики на регіональному, національному і глобальному рівнях. Підкреслено, питання паритетного партнерства громадянського суспільства та держави набуває виняткового значення для сучасної України, екологічні показники якої за оцінками вітчизняних і міжнародних експертів щороку погіршуються. У підсумку стверджується, українське громадянське суспільство та потужний інструментарій його інститутів наділені достатнім потенціалом для реальної трансформації екологічної політики нашої
держави, у відповідності до нагальних потреб із захисту навколишнього середовища і збереження національних природних ресурсів.
Ключові слова: громадянське суспільство, громадянське суспільство та його
інститути, розвинене громадянське суспільство, політична та соціальна участь, політична та соціальна відповідальність, соціально-політична конвергентність, екологічна політика, екологічна проблематика, діалектика взаємозв’язку
Isolation and characterisation of potential probiotic yeast strains from local fermented foods: Gastrointestinal tolerance and antimicrobial activity assessment
Authors: Murad Amirul Syafiq , Zuhairi Nur ‘Ain , Mohd-Aspar Mohd Amir Shahlan , Azhar Mohd Akmal
Published: March 2024

Probiotic microorganisms, offering health benefits when consumed in sufficient quantities, are gaining recognition for their potential role in promoting wellness. This study focuses on isolating and characterising potential probiotic yeast strains sourced from fermented food products. This research evaluates the gastrointestinal tolerance and antimicrobial activity of isolated yeast strains, with the potential application in probiotic supplements and functional foods. Yeast strains were isolated from fermented food sources and identified using morphological analysis, PCR, gene sequencing, and genetic identification. Gastrointestinal tolerance was assessed through simulated gastric fluid (SGF) exposure, and antimicrobial activity was tested against foodborne pathogens. Six yeast strains (Diutina mesorugosa, Pichia kudriavzevii, Candida mesorugosa, Candida sp) were identified. They exhibited varying resistance to low pH in SGF, suggesting survivability in the stomach. Some strains selectively inhibited specific Gram-negative pathogens like Pseudomonas aeruginosa and Salmonella sp. These findings suggest the isolated yeast strains may serve as probiotics, promoting digestive health and food safety. They are potentially used in probiotic supplements and functional foods, promising improved overall well-being.
LITERASI MEDIA SOSIAL DALAM PROMOSI PRODUK PADA KELOMPOK USAHA BERSAMA GRAHA PERMAI DI KELURAHAN TUAH KARYA KECAMATAN TUAH MADANI
Authors: Hadiyati Hadiyati , Fatkhurahman Fatkhurahman , N Arizal
Published: March 2024

Pentingnya pengetahuan tentang promosi produk melalui media sosial sangat penting, terutama dalam konteks bisnis modern. Media sosial adalah platform dengan jutaan pengguna aktif harian. Pengetahuan tentang cara memanfaatkan platform ini akan membantu mencapai audiens yang lebih luas dan berinteraksi dengan mereka secara lebih efektif. Dunia bisnis semakin digital. Jika tidak memahami media sosial, mungkin tertinggal dalam pemasaran dan promosi produk. Pengetahuan ini memungkinkan untuk tetap relevan dalam era digital.
Tim pengabdian mengagendakan pelatihan cara mengelola akun media sosial dalam berwirausaha dengan maksud anggota kelompok mendapatkan pendapatan atau penjualan yang mereka hasilkan sehingga daya saing usaha semakin baik.   Metode yang digunakan adalah dengan memberikan penjelasan arti pentingnya media sosial dan promosi melalui media sosial melalui ceramah; Melaksanakan demonstrasi cara mengelola akun dan membuat konten yang dihasilkan dengan maksud membuka wawasan anggota dalam menghasilkan konten kreatif; Memberikan saran ide kreatif seperti apa dari masing-masing produk dipromosikan anggota kelompok dalam bentuk Tanya jawab.    Berdasarkan hasil pengabdian masyarakat yang dilakukan sebelum dan setelah dilaksanakan kegiatan terjadinya peningkatan pengetahuan, pemahaman dan kemampuan anggota KUB Graha permai dalam literasi media sosial, dimana sebagian besar dari anggota mengetahui perkembangan dan jenis media sosial yang dapat digunakan untuk promosi produk. Kedua mereka memahami fungsi dan manfaat yang potensial pada setiapa media sosial yang ada dan ketiga mereka sudah mulai mampu membuat konten kreatif pada media sosial dan ini menunjukkan perubahan kemampuan mereka dalam menggunakan media sosial dalam promosi produk..
MMP-1 and MMP-7 Expression is Influenced by Ginsenosides in Mice Exposed to Aflatoxin B1: in vivo Study
Authors: Abdulateef Safa M , Ibraheem Shaima R. , Hussein Humam S , Dheeb Batol imran , Khashman Basim Mohammed , Ahmed Dunya Muayed , Abu-Elteen Khaled H , Abu-Qatouseh Luay
Published: March 2024

Panax ginseng (PG), one of the most widely used herbal medicines, has demonstrated various beneficial effects such as anti-inflammatory, antioxidant, and anticancer impacts. Naturally occurring ginsenosides in the ginseng plant inhibit cell proliferation and significantly reduce liver damage induced by certain chemicals. Aflatoxin B1 (AFB1) is a primary mycotoxin due to its hepatotoxic, immunotoxic, and oncogenic effects in animal models and humans. In this study, we examined the effects of assorted doses of PG aqueous crude extract on the expression of matrix metalloproteinase 1 and 7 (MMP-1 and MMP-7) in the kidney, spleen, and liver of experimental AFB1-exposed mice, using immunohistochemistry (IHC). Mice were orally administered 6 mg/kg body weight (bw) of refined AFB1 (isolated and extracted from Aspergillus flavus, conc. 0.05 ppm) twice weekly for two weeks. We then compared the effects of three different doses (50, 100, and 150 mg/kg bw) of crude ginseng. We estimated the expression of MMP-1 and 7 in organs using IHC. We used the 6 mg/kg of purified AFB1, representing a 60% concentration, as a control group. IHC analysis showed that MMP (1 and 7) expression in the spleen, liver, and kidney of mice decreased after treatment with ginseng crude extract. MMP-1 expression was reduced in the liver by approximately 2.6 times, while the effectiveness in the MMP-1 reduction reached 9 and 8 times, respectively, in the spleen and kidney when treated with a higher dose of PG compared to the control. MMP-7 expression was reduced in the liver by approximately 13 times, while the reduction effectiveness fell to 2.3 and 5.6 times in the spleen and kidney when treated with a higher dose of PG compared to the control. The reduction in MMPs expression due to the effect of PG aqueous crude extract was observed to act against the effect of AFB1 on various living organs involved in AFB1 metabolism. IHC analysis indicated a more significant reduction efficiency observed in the expression of MMP-7 compared to both studied markers in the mice's liver.
How I treat peripheral T-cell lymphomas
Authors: Gorenkova L.  G. , Mangasarova Ya. K. , Kovrigina A. M. , Kravchenko S. K. , Klebanova E. E. , Bagova M. O. , Chabaeva Yu. A. , Margolin O. V. , Zvonkov E.  E.
Published: March 2024

Introduction. Peripheral T-cell lymphomas (PTCL) — a rare group of lymphoproliferative diseases characterized by an aggressive course and an unfavorable prognosis. The group is represented by heterogeneous nosological forms, in which standard treatment options lead to unsatisfactory results. Aim: to present the protocols for the treatment of PTCL

Main findings. In total, 12 years of experience in the treatment of 724 patients with T-cell lymphomas (430 patients with primary cutaneous forms, 110 patients with leukemic variants and 184 with peripheral T-cell lymphomas) has been accumulated. The treatment results and therapeutic algorithms were analyzed. In the general group of patients, the 3-year overall survival (OS) and relapse-free survival (EFS) were 76 % and 70 %, respectively. The best treatment results were achieved in the groups of intestinal T-cell lymphoma, specifically (EATL), and angioimmunoblastic T-cell lymphoma (AITL), anaplastic large cell ALK-positive lymphoma (ALCL ALK+), and the worst — in the group of ALCL ALK- (5-year EFS 31 %). High-dose chemotherapy under the NHL BFM-90 program in the treatment of ALK+ ALCL allows achieving 10-year OS and EFS 87 % and 84 %, respectively, but the less toxic CHOEP program was not inferior in effectiveness: 5-year OS and EFS amounted to 93 % and 88 %, respectively. High survival rates of patients with EATL were achieved with the use of high-dose chemotherapy according to the LB-M-04 program followed by auto-HSCT in the first line of therapy: 5-year OS and EFS amounted to 79 % and 74 %, respectively. The positive role of AITL maintenance therapy has been shown: 5-year OS and EFS during its implementation amounted to 75 % and 49 % versus 41 % and 20 % in the absence of it. In the protocols for the treatment of extranodal NK/T cell lymphoma, radiation therapy was used in the first line of therapy, 5-year OS and EFS were 60 % and 42 %, respectively. The role of autologous hematopoietic stem cell transplantation (auto-HSCT) in all PTCL was evaluated: 5-year OS and EFS were 82 % and 58 % compared with 67 % and 49 % without auto-HSCT. The transplantation of allogeneic hematopoietic stem cells (allo-HSCT), even in the treatment of relapses of the disease, has shown its effectiveness: 9 out of 11 patients are alive and remain in remission of the disease.
INGLIZ VA O‘ZBEK DRAMALARIDA VERBAL VA NOVERBAL VOSITALAR MUNOSABATI
Authors: KHURSANOV Nurislom
Published: March 2024

Zamonaviy tilshunoslikning turli sohalari tadqiqot obyekti, metodologik masalalari bilan bir-biridan farqlanadi, ayni damda bir-birini taqozo etadi. XX asr oxirlaridan boshlab antroposentrik paradigma to‘g‘risidagi qarashlarning ustuvorligi bir qator fanlararo sohalar, jumladan, lingvopragmatikaning paydo bo‘lishi uchun zamin hozirladi. Dunyo tilshunosligida ikki til imkoniyatlarini o‘rganish, bir tildan ikkinchi tilga tarjima jarayonida yuzaga keladigan fikriy ifoda, uning shakliy tuzilishi, ichki nutq imkoniyatlarini va aniq struktur xususiyatlarini tahlil qilishga qaratilgan tadqiqotlar yaratilmoqda. Diskurs jarayoni, verbal va noverbal komponentlarning nutq vaziyatidagi o‘rni, adresat va adresant lisoniy ongi, madaniyatlararo munosabat belgilari, baho va talqin muammolari tadqiqi til birliklarining nutqda reallashuv imkoniyatlarini yoritishga xizmat qiladi. Dramatik diskursda verbal va noverbal komponentlar munosabatini o‘zbek va ingliz tillari aspektida tadqiq etish tilshunoslik sohasidagi dolzarb mavzulardan biridir. Maqolada ingliz va o‘zbek dramalarida qo‘llanilgan verbal va noverbal vositalar munosabati, mazkur vositalarning diskursiv, lingvokultrologik hamda sotsiolingvistik tahlili keltirilgan.
Inga Hedberg (1927-2024) – inspirational driving force in tropical African botany for 60 years
Authors: Friis Ib , Demissew Sebsebe , Thulin Mats
Published: March 2024

Docent, fil. dr. Inga Hedberg (Fig. 1)  died in Uppsala on the 13th of January 2024, at the age of 96 years. Together with her husband, Olov Hedberg, she has been a central and tireless figure in a range of important international projects on African botany, probably with the Flora of Ethiopia and Eritrea (1980-2009) as the most remarkable.
PENGARUH SENAM KAKI TERHADAP SKOR IPSWICH TOUCH TES PADA PASIEN DIABETES MELITUS TIPE 2 DI WILAYAH KERJA PUSKESMAS CIGEUREUNG TASIKMALAYA
Authors: Lutfi S Baharudin , Mutiudin Ade Iwan , Mulyana Asep , Mulyani Diyah Sri
Published: March 2024

Diabetes mellitus tipe 2 menjadi masalah penting bagi kesehatan masyarakat dengan komplikasi yang banyak dialami salah satunya perubahan sistem saraf perifer atau disebut neuropati perifer. Salah satu cara dalam mencegah neuropati perifer adalah melakukan senam kaki dan rutin memeriksa tingkat sensitifitas kaki diantaranya dengan Ipswich touch test. Tujuan peneliti untuk mengetahui pengaruh senam kaki terhadap skor ipswich touch test pada pasien diabetes mellitus tipe 2 di wilayah kerja Puskesmas Cigeureung Tasikmalaya. Metode yang digunakan adalah penelitian kuantitatif dengan desain penelitian pre eksperimental. Responden dalam penelitian ini merupakan pasien diabetes melitus tipe 2 di wilayah kerja Puskesmas Cigeureung Tasikmalaya sebanyak 16 orang. Teknik pengambilan sampel menggunakan Faderer. Pengumpulan data dilakukan dengan menggunakan lembar ceklis observasi pretest posttest intervensi senam kaki. Analisa data menggunakan metode T-Test. Hasil penelitian menunjukan p-value 0,000 yang lebih kecil daripada nilai α : 0,05 (p<0,05) ini berarti bahwa H0 ditolak dan Ha diterima. Maka dapat disimpulkan bahwa terdapat pengaruh senam kaki terhadap skor ipswich touch test pada pasien diabetes mellitus tipe 2 di wilayah kerja Puskesmas Cigeureung Tasikmalaya tahun 2022.
PERBEDAAN NILAI HEMATOKRIT MENGGUNAKAN METODE MIKROHEMATOKRIT DENGAN METODE AUTOMATIK HEMATOLOGY ANALYZER BC-2300
Authors: Hasanah Annisa Nur , Hidayat Taufik
Published: March 2024

Hematology analyzer merupakan alat otomatis yang digunakan untuk pemeriksaan hematologi rutin termasuk salah satunya hematokrit. Namun di beberapa laboratorium pemeriksaan hematokrit dengan cara konvensional menggunakan alat mikrocentrifuge masih digunakan. Lembaga ICSH (Internasional Council Standardization in Haematology) menetapkan pemeriksaan hematokrit menggunakan metode mikrohematokrit sebagai gold standard dalam pemeriksaan hematologi rutin. Nilai hematokrit didapatkan dengan cara membaca garis yang terbentuk dari pemisahan sel-sel darah merah dengan plasma menggunakan skala hematokrit. Dengan perkembangan teknologi laboratorium yang menyesuaikan dengan kebutuhan layanan laboratorium. Pemeriksaan hematologi sekarang ini dapat dilakukan menggunakan alat hematology analyzer termasuk pemeriksaan hematokrit. Pada pemeriksaan hematokrit menggunakan alat hematology analyzer tidak memerlukan sentrifugasi. Tujuan dari penelitian ini untuk mengetahui perbedaan nilai hematokrit menggunakan metode mikrohematokrit dengan alat automatic hematology analyser BC-2300. Jenis penelitian yang digunakan bersifat eksperimen dengan sampel sebanyak 10 responden yang berasal dari mahasiswa/i universitas BTH. Sampel responden kemudian dilakukan pemeriksaan hematokrit menggunakan metode mikrohematokrit dan alat hematology analyzer. Setelah dilakukan pemeriksaan, nilai Ht terendah pada metode mikrohematokrit 41% sedangkan nilai tertinggi 46% dengan nilai rata-rata 44% sedangkan untuk metode hematologi analyzer nilai hematokrit terendah  45% dan nilai tertinggi 51% dengan rata-rata 48%. Hasil pemeriksaan diolah menggunakan uji statistik T-Test dan menunjukkan nilai p=0,065 bahwa tidak terdapat perbedaan yang signifikan. Berdasarkan hasil penelitian tersebut maka pemeriksaan hematokrit dapat dilakukan menggunakan metode microcentrifuge ataupun menggunakan alat hematology analyzer yang disesuaikan dengan keperluan pemeriksaan.
Etkin Yurttaş, Özgürleşme, Elit Bir Demokrasi Anlayışı: Arendt’in Demokrasisi
Authors: Çalışır Seda
Published: March 2024

Bu çalışma, Hannah Arendt’in eserlerinde doğrudan yer almayan demokrasi kavramının anlamının ortaya çıkarılmasına ve sınırlarının çizilmesine odaklanmaktadır. Bu amaçla, modern dünyanın dinamikleri ile Arendt’in demokrasisi olarak isimlendirilen kavramın benzeştiği ve çatıştığı alanlar ile içinde yer alabilecek aktörlerin rolleri de tartışılmaktadır. Yurttaşların itaat eden varlıklar haline geldiği, sorgulama ve bireyliğini ortaya koyma yetisini harekete geçirmesine ket vurduğu, insani çoğulluğun zedelendiği durumlar, düşünce ve eylem dünyasının kopukluğunun zirve yaptığı noktalardır. Arendt’in tasvirinde, düşünceden kopuk bir egemenlik anlayışı, temsili demokrasinin sınırlarını en başından belirler. Bu durumda, özgürlük, egemenlik tanımına yakın ya da eşdeğer kabul edildiğinden, yurttaşların ortak iyiye ulaşma beklentisi eksik kalmaktadır. Bir başka deyişle, toplumsal sözleşmenin belirli çıkarlar karşılığında rıza yoluyla devredilmesi ortak iyinin garantisi olmadığı gibi, bireyler çoğulluğun ikileminde sıkışıp kalmaktadır. Bu ikilemden kurtulmanın çaresi Arendt’e göre, bir uyanış ve yeniden doğuş gibi hayal ettiği sorumlulukla hareket eden etkin yurttaşların kamusal alanda eyleme geçmesidir. Politik sorumluluğu taşıyanlar etkin yurttaşlar olacaktır. Bir başka deyişle Arendt’in demokrasisi, varoluşsal sorumlu yurttaş olabilmenin yollarını keşfetmek isteyenler için bir kılavuz önermesidir. Bu önermenin kısıtları incelendiğinde, ortaya elit bir demokrasi anlayışının çıktığı sonucuna varılmaktadır.
VALIDADE DE CONTEÚDO DO MÓDULO DE QUALIDADE DE VIDA PARA FAMILIARES DE PESSOAS COM CÂNCER
Authors: Oliveira da Silva Bastos Aminne , Santana Freitas Katia , Borba de Almeida Igor Ferreira , Lima dos Santos Vanessa Marcela , Lima dos Santos Vivian Manuela , Campos Oliveira Márcio
Published: March 2024

Objetivo:validar o conteúdo domódulo de qualidade de vidade familiares de pessoas com câncer. Método:Desenvolveu-se em etapas de elaboração do instrumento, avaliação por peritos e compreensão semântica pelo público alvo. Os dados foram descritos em frequência simples e analisados por meio do cálculo do Índice de Validade de Conteúdo, superior a 0,78.Resultados:Aconfecção dos itens do instrumento através dolevantamento de bases teóricas na literatura e a elaboração da matriz de especificações originou 40 itens. Após a análise por especialistas, obteve-se 21 itens para o pré-teste e Índice de Validade de Conteúdo global e razão de validade de conteúdo. No pré-teste, 5 itens foram reformulados e excluídos, obtendo-se 16 itens. Conclusão:O desenvolvimento e a validação de conteúdo do resultou em um instrumento conceitualmente apropriado para avaliar familiares de pessoas com câncer, estando apto a prosseguir para a validação empírica.
HOTEL STAFF TRAINING AND THE EFFECTIVENESS OF ALTERNATIVE TRAINING TECHNIQUES
Authors:   PhD degree student of the Department of Hotel and Tourist Business Plekhanov Russian University of Economics, Russian Federation, Moscow, Mirzayeva Gunel V.
Published: March 2024

The hotel industry is one of the fastest-growing and most dynamic sectors of the economy, characterized by high labor intensity. This means that employees in this field must possess a high level of professionalism and competence to ensure quality guest service. However, despite the importance of education and qualifications, the hospitality industry faces serious challenges in terms of personnel potential, which is a relevant issue even for Russian hotels. Training plays a key role in shaping the professional skills and knowledge of employees necessary for the effective performance of their duties. Effective training methods can significantly increase staff productivity and improve service quality, thereby contributing to the competitiveness of hotel enterprises. This study offers a set of recommendations to managers, entrepreneurs, and policymakers in the hotel industry aimed at optimizing staff training processes and enhancing the efficiency of hotel businesses in Russia.
Development of the potential-forming space of regional economic systems based on digitalization
Authors:   Simon Kuznets Kharkiv National University of Economics, Perepeliukova Olena
Published: March 2024

The article studies the peculiarities of forming the potential-forming space of regional economic systems. The peculiarities of the functioning of regional economic systems in the context of the digitalization of the economy are substantiated. It is determined that today, the issues of allocating types of potential are complex, which significantly expands the methodological approaches to its assessment. It is proved that the development of the potential-forming space is aimed at improving the population’s welfare, reducing unemployment, and intensifying the introduction of digital technologies, which will increase the overall competitiveness of regional economic systems. It is substantiated that a wide variety of natural conditions, the level of development of productive forces, peculiarities of labor and natural resources allocation, and historically formed areas of specialization necessitate considering many local positive and negative factors that affect the processes of use and development of the potential of regional economic systems. The main elements that make up the potential-forming space are allocated, which allows the formulation of appropriate directions for the development of regional economic systems in the new conditions of digitalization. It has been proved that the digitalization of regional economic systems is a complex process that requires close cooperation between government, business, scientific institutions, and the public to implement relevant programs successfully. It is established that the introduction and modernization of information and communication infrastructure is one of the key elements based on the use of broadband Internet technologies, improvement of network security, and development of digital platforms. The development of the e-government system, which significantly improves the accessibility and efficiency of public services, reduces bureaucracy. It is determined that in the framework of the development of regional economic systems, digital infrastructure (hubs, incubators) is currently actively used as a platform for supporting local entrepreneurship and contributing to creating an environment for innovative development. Keywords: development, potential, regional economic systems, digitalization, space.
Current tendencies in the development of communication activities as a tool of public administration
Authors: Vylhin Yevhen , Beliavceva Victoria ,   Simon Kuznets Kharkiv National University of Economics
Published: March 2024

The article analyzes the communication paradigm of relations between government and society. The main functions of state communication are analyzed. Different stages of the communicative process are considered. Modern approaches in the field of management of political and communicative processes in government bodies are highlighted. Attention is drawn to the complication of the social structure and connections, the increase of non-state participants in the political process, the formation of the infrastructure of the information society, and the growing role of horizontal connections, which require new approaches in managing political processes. The focus of the scientific article is on new communication practices and the possibilities of their use in political activity, among which strategic management technologies and PR activities, crowdsourcing technology, Internet technologies, and network communities stand out. On the one hand, new information technologies can significantly transform the modern communication practices of authorities, contributing to the establishment of rigid forms of power based on subordination and subject-object relations. On the other hand, information can be used to form a new image of power, which received the concept of “soft power” in the literature, using “soft technologies”. In modern democratic states, for the most part, the interaction of authorities with the objects of the socio-political process is ensured by using political communication tools and developing feedback mechanisms. The role of communication relations in the public administration system is growing, and the communication component of political reality is changing and becoming increasingly complicated. Legitimate interaction mechanisms between authorities and society are now formally established in Ukraine. However, their effectiveness is constantly questioned by both political scientists and the very objects of the socio-political process. The strategic transformations currently taking place in the country’s political life, following a change during political and socio-economic development, also suggest a change in the political and communication component of the political process. At the same time, the government itself at the highest level puts forward new requirements for political communication of the authorities, which consist of a reorientation to an open discussion of the strategies and directions of the country’s development, as well as a transition to an open and interactive format of interaction. Keywords: public administration, communication, public relations, public communication, stages of communication.
Profiling energy metabolism in normal bladder tissue and non-muscle-invasive bladder cancer cases of different histological grades
Authors: Costa Guilherme Prado , Böckelmann Petra Karla , Costa Renato Prado , Schaal Carlos Hermann , Sala Fernando César , Vanni André Pereira , de Freitas Leandro Luiz Lopes , Alonso João Carlos Cardoso , Camargo Gabriela Cardoso de Arruda , de Oliveira Gabriela , de Souza Bianca Ribeiro , Billis Athanase , Fávaro Wagner José
Published: March 2024

Bladder cancer (BC) stands as the second most common urinary tract malignancy. Recent years have witnessed a growing interest in investigating energy metabolism to help with better understanding the energy sources harnessed by tumor cells. The aims of the present study are to feature and compare cell energy metabolism profiles among different histological grades of non-muscle-invasive BC (NMIBC) by adjusting their bioenergetic cellular indexes based on the specific tumor types. Forty urinary bladder tissue samples from patients both with and without a diagnosis of urothelial lesions were collected. Subsequently, samples were categorized into four groups comprising ten samples each, namely: normal (no urothelial lesions) group, low-grade pTa group, high-grade pTa group, and high-grade pT1 group. These tissue samples were examined by means of immunohistochemistry and Western blotting to assess proteins involved in cell energy metabolism. Based on the current findings, the normal and low-grade pTa groups presented clear preference for the oxidative phosphorylation pathway; consequently, they recorded high bioenergetic cellular index. On the other hand, both the high-grade pTa and pT1 groups presented proclivity towards the glycolytic pathway. These observations, mainly those associated with the bioenergetic cellular index, hold promising clinical relevance in the management of BC. Given the often aggressive and potentially debilitating nature of treatments applied to this neoplasia type, the current study offers invaluable insights on this topic and emphasizes changes in the bioenergetic cellular index at different NMIBC grades, which could serve as potential markers for both the diagnosis and prognosis of NMIBC patients.
Estrategias de transición ecosocial desde la arquitectura y el turismo: proyectos de desurbanización y recuperación ecológica en destinos costeros
Authors: Romero-Martínez José María , Del-Castillo-Sánchez Alejandro , Romero-Padilla Yolanda
Published: March 2024

Las costas del mediterráneo son ecotonos frágiles con crecimiento de población, actividad económica y urbanización; son máquinas de crecimiento urbano-turístico. Además, presentan problemáticas económicas, sociales y ecológicas en la crisis crónica global. Su sobredimensión es una barrera para la transición ecosocial. El decrecimiento promueve reducir el metabolismo económico, constructivo y territorial, y la adaptación ecológica. Son escasas sus prácticas espaciales y arquitectónicas. La academia no ha analizado ni caracterizado las prácticas existentes. La investigación analiza proyectos de desurbanización, desconstrucción y recuperación ambiental, que responden a la sobreconstrucción de las costas turísticas. Son referentes para la gestión de políticas y estrategias de transición ecosocial y recuperación ecológica de destinos turísticos. La sistematización facilita la replicabilidad.
The Role, Obstacles, and Challenges of the Forestry Police in the Pesapa FMR’s Work Area
Authors: Nasrullah Nasrullah
Published: March 2024

This research examines the role of the Forestry Police and the obstacles and challenges they face in combating illegal logging in the Pesapa FMR’s Work Area. Employing empirical research methods, it utilizes primary and secondary data from April to June 2023 in Batulappa Sub-district, Pinrang Regency, Indonesia. The study then analyzes the acquired data qualitatively to describe the problem and answer the research objectives. The findings reveal that the Forestry Police in the Pesapa FMR’s Work Area encounter several obstacles and challenges in executing forest protection. These obstacles include limited functional officers and equipment, the extended area of the protection forest requiring safeguarding, and the Batulappa community’s lack of understanding about forest boundaries and functions. Another emerging factor is the suboptimal law enforcement by the Forestry Police, especially in illegal logging cases involving local communities. Therefore, the Head of the TIU of Sawitto FMU is recommended to increase the number of functional officers and ownership of Forestry Police equipment in the Pesapa FMR’s Work Area. Furthermore, a continuous education program on the importance of forest conservation and the dangers of illegal logging for the Batulappa community must also be implemented. The Local Government must also seek alternatives for agricultural and plantation land use. Lastly, the Forestry Police must show a more substantial commitment to handling illegal logging cases, reinforcing the Government’s dedication to forest protection.
A lei anticorrupção e seus prinicipais aspectos: o procedimento administrativo de responsabilização, o programa de integridade e o acordo de leniência
Authors: Cardoso Henrique Ribeiro , Loiácono  Neto Vicente , Ferrari Flávia Jeane
Published: March 2024

Objetivo: Esta pesquisa visa investigar brevemente a Lei Anticorrupção Empresarial, enfatizando a responsabilização objetiva das entidades jurídicas, o Procedimento Administrativo de Responsabilização (PAR), os fundamentos do Programa de Integridade e a natureza e funcionalidade do Acordo de Leniência.
 
Metodologia: Adotou-se uma abordagem dedutiva, analisando doutrinas, livros e artigos de periódicos especializados, além da legislação pertinente do Brasil.
 
Resultados: Identificou-se que a Lei Anticorrupção estabelece mecanismos de prevenção, incluindo requisitos mínimos para Programas de Integridade eficazes, visando prevenir atos prejudiciais à Administração Pública por parte de indivíduos representando entidades jurídicas. Destaca-se a importância de cooperar com autoridades na detecção de má conduta. Em relação ao Acordo de Leniência, sugere-se reavaliar certos aspectos para melhorar a eficácia da lei, criticando a restrição de sua aplicabilidade e os benefícios limitados. Outro ponto de atenção é a possibilidade de isenção total de multas e a limitação de acordos exclusivamente às primeiras entidades que propõem ajustes. Apesar de áreas necessitarem de melhorias, a Lei Anticorrupção e seu regulamento representam um progresso notável na promoção de uma cultura ética nas relações entre o setor público e privado, incentivando a prevenção, detecção e cessação de atos prejudiciais, além da reparação de danos à sociedade.
 
Contribuições: O estudo esclarece e divulga informações sobre o PAR e o Acordo de Leniência, tópicos recentes no âmbito do Direito Administrativo e Penal brasileiro.
TECHNOLOGIES AND TECHNICAL TOOLS USED IN PREPARING LAND FOR PLANTING ANALYSIS
Authors:   Gulistan State University, Syrdarya, Uzbekistan, Ermamat Qurbonov , Ikrom Xudoyberdiyev ,   Gulistan State University, Syrdarya, Uzbekistan, Dilorom Yuldasheva ,   Gulistan State University, Syrdarya, Uzbekistan
Published: March 2024

In this article, the analysis of field leveling and compacting machines used in the preparation of land for planting seeds and the research conducted on them, the improvement of the technological work process of the leveler and the justification of its parameters, the improvement of work quality and productivity in the preparation of land for planting seeds of seeds and other crops are discussed.
ORGANIZATIONAL AND LEGAL SUPPORT OF THE PROBATION SERVICE'S ACTIVITY OF CORRECTIONAL WORK
Authors:   Responsible employee of the ministry of internal affairs, Uzbekistan, Hamzayevich Altmishev Temur
Published: March 2024

In this article, the opinions of legal scholars and practitioners regarding the organizational and legal support of the execution of the punishment of correctional works of the probation service are studied, and proposals and recommendations are developed.
ANALYSIS OF PROBLEMATIC ISSUES BETWEEN DOMAIN NAMES AND OTHER MEANS OF INDIVIDUALIZATION
Authors:   Lecturer At TheDepartment Of “International Law And Human Rights”, Tashkent State University Of Law, Uzbekistan, Shahnoza Almosova
Published: March 2024

In the article, the author studies the similarities and differences between domain names and individualization means, as well as the growing number of problems between domain names and individualization means due to the globalization of the Internet and the proliferation of e-commerce. The commercial significance of domain names is directly reflected in the disputable situations. The article also lists the objects of intellectual property that are not registered as domain names under the legislation of the Republic of Uzbekistan and not prohibition of the registration of domain names that are identical or confusingly similar to a trademark or service mark is brought up as a matter of discussion.
LEGAL NATURE OF CITIZENS' PARTICIPATION IN THE PROCESS OF MAKING OF NORMS
Authors:   Senior Teacher Of Tashkent State Law University, Phd In LawUzbekistan, Ugli Boymurodov Botir Panji
Published: March 2024

In this scientific article, the legal nature of citizens' participation in the process of norm making is analyzed from a scientific-theoretical point of view and explained from different angles. In the process of reading the scientific work, it becomes clear that the participation of citizens is not only a mature and thorough preparation of the accepted normative legal acts, but also one of the important steps in building a civil society. This article is intended for students of legal educational institutions, researchers conducting scientific research, and a wide range of readers.
TRANSFORMATION OF THE ECONOMY IN THE DIGITAL ERA: EXPERIENCE OF UZBEKISTAN AND DEVELOPMENT STRATEGIES
Authors:   Tashkent International University “KIMYO”, Uzbekistan, Atamirzaevich Olimov Anvarjon
Published: March 2024

This article examines the processes of transformation of the economy of Uzbekistan inthe context of the digital era. The main focus is on analyzing the country’s experience in the use of digital technologies and developing development strategies in a rapidly changing digital landscape. The study includes an analysis of key initiatives aimed at promoting digital transformation, such as developing digital infrastructure, introducing e-government, stimulating digital entrepreneurship and educational programs in the field of digital technologies. The author of the article also considers strategic directions of development, identifies successful practices and highlights the challenges facing Uzbekistan in the process of digital transformation, providing valuable recommendations for the further development of the economy in the digital age.
THE POSSIBILITIES OF ULTRASOUND IMAGING IN THE DIAGNOSIS OF ACUTE IDIOPATHIC SCROTAL EDEMA IN CHILDREN
Authors:   MD, Associate Professor of the Department of Pediatric Surgery No. 2, Samarkand State Medical University, Samarkand, Uzbekistan, Mavlyanov Farkhod Shavkatovich , Mavlyanov Shavkat Khojamkulovich ,   Candidate of Medical Sciences, Associate Professor of the Department of Pediatric Surgery No.2, Samarkand State Medical University, Samarkand, Uzbekistan, Tukhtaev Firdavs Mukhiddinovich ,   Senior Lecturer at the Department of Surgical Diseases No. 1, Transplantation and Urology, Samarkand State Medical University, Samarkand, Uzbekistan
Published: March 2024

Despite many years of experience in the use of ultrasound in the diagnosis of acute testicular ischemia (AISE) in children, the full potential of this technique remains insufficiently studied. As part of a prospective controlled study involving 142 patients with emergency genital disorders, ultrasound was performed for Acute idiopathic scrotal edema. Ultrasound showed differences in the image of the scrotum organs in boys with AISE, depending on the duration of the disease. When using color Dopplerography, changes in perfusion were detected, such as the absence or decrease in blood flow. The localization of the inflammatory process was determined solely by the results of ultrasound of the scrotum organs. The results obtained suggest that with a decrease in blood flow in the testicles with a more pronounced degree or with a longer period of torsion, pronounced changes on the part of the scrotum were observed.
Plastik Sanatlar Alanında Seramik ve Cam Üzerine Yaklaşımlar 2
Authors: Tazeoğlu Filiz Ferda , Tonza Helvacıkara Fidan , Gülaçtı Nurettin , Gümüş Akman Nagihan , Kuyrukcu Dilek , İba Şeyma Müge , Uslu Ali , Görgünay Gamze , Tanrıverdi Yaprak , Yılmazer Yunis
Published: March 2024

Çağdaş Seramik Sanatında Kullanılan Astar Dekorları ve Uygulama Yöntemleri
Ferda TAZEOĞLU FİLİZ
Seramik Sanatında Doğanın Taklidine Dayalı
Güncel Dekor Uygulamaları
Fidan TONZA HELVACIKARA
Seramik Sanatı ve Bugünkü Konumu
Nurettin GÜLAÇTI
Seramik Sanatında Tema - Konu Üzerine Bir İnceleme
Nagihan GÜMÜŞ AKMAN
Türk Seramik Sanatı: Yıldız Çini ve Porselen Fabrikası’nın Köklü Mirası ve Etkisi
Dilek KUYRUKCU
 “Yeni Brütalist” Heykel Pratiklerinde Seramik Kullanımı
Şeyma Müge İBA
Toplumsal Gerçekçilik İçerisinde Cihat Burak ve El Ense Çekenler
Ali USLU
17-18.YY. Porselen Fabrikalarının İşaret (Mühür) Benzerlikleri: Almanya, Fransa ve İngiltere Örneği
Gamze GÖRGÜNAY
Mozaiğe Seramik ve Camın Katılımı: Adıyaman Mozaikleri Üzerine Bir İnceleme
Yaprak TANRIVERDİ
Basınçlı Döküm Sistemi
Yunis YILMAZER
Yüksek Dereceli Odun Yakıtlı Fırınlarda Kül Sırının Dönüştürücü Etkisi ve Fırınlama Aşamaları
Bahadır Cem ERDEM
The effect of self-efficacy on the quality of life of elderly long-term care institution users
Authors:   The Korea Academy of Case Management, kang cheon kook , Choi Se-yeong
Published: March 2024

The purpose of this study is to find out the effect of self-efficacy of users of long-term care institutions for the elderly on the quality of life. This study surveyed and analyzed a total of 374 elderly people at elderly care institutions located in Seoul, Gyeonggi, and Chungcheong from October 2021 to April 2022. The results of the study on the effect of self-efficacy on life are as follows. First, self-acceptance (β=) among the sub-factors of self-efficacy of physical satisfaction.363, p<.001) and social efficacy (β=.136, p<.05) was statistically significant. Second, among the sub-factors of self-efficacy of psychological satisfaction, self-fulfillment (β=).247, p<.001), social efficacy (β=.203, p<.01), self-acceptance (β=.190, p<.01) was statistically significant. Third, among the sub-factors of self-efficacy of social satisfaction, social efficacy (β=.376, p<.001) and self-acceptance (β=.233, p<.001) was statistically significant. Fourth, self-acceptance (β=) among the sub-factors of self-efficacy of indoor living environment satisfaction.159, p<.05) and self-fulfillment (β=.150, p<.05) and outdoor living environment and self-acceptance (β=.159, p<.05) and self-fulfillment (β=.150, p<.05) was statistically significant. These results suggest that self-efficacy plays an important role in improving the quality of life of users of long-term care institutions for the elderly.
A Qualitative Case Study of In-home Elderly Support Service Social Workers’ Experiences in Transitioning Care for Unrelated Elderly People Living Alone
Authors:   The Korea Academy of Case Management, Jeong Eun hee
Published: March 2024

This study aims to explore ways to change the care system so that unrelated elderly people can be represented when they need to be admitted to nursing homes or nursing hospitals, to the extent that their self-determination is respected and supported as much as possible. For this purpose, in-depth interviews were conducted with five participants who had experience in care transition for unrelated elderly living alone among social workers providing services affiliated with senior welfare centers, and analyzed using Yin’s (2009) case study data analysis method. Through this, we derived five constructs as a result of the study, including “unfortunate situation of the elderly,” “work dilemma,” “little institutional and organizational support,” “saving the elderly living alone without ointment,” and “desire,” and further established 12 subconstructs and 48 semantic units. From this research, we recommend the following policies. First, social workers and local governments in charge of providing in-home elderly support services should be authorized to represent unrelated elderly people living alone. Second, the number of people eligible for public guardianship for dementia should be expanded and the application process should be simplified.
Indebtedness in India- A Region Wise Analysis Leveraging Machine Learning By IJISRT
Authors: Singh Gurinder , Kaur Kulwinder
Published: March 2024

The risk of indebtedness across region level is higher among the households having less human and physical assets and human resources. However, because of their better borrowing capacities, the extent of indebtedness among them is significantly higher than other segment of the rural society. The same is true about the households self-employed in various agricultural and non-agricultural activities in the rural areas. The region level analysis also rejects the contention that the higher consumptive expenditure of the rural people as a cause of their risk of indebtedness whereas the extent of indebtedness confirms that consumptive expenditure plays a major role in their indebtedness. Similarly, the hypothesis of agricultural prosperity and indebtedness going together lacks wider generalization for household located in all the regions except North-West states in Logistic regression and in North-Western, Eastern and Southern region in Tobit regression. Exposure of rural households to higher risk and uncertain situations like droughts, floods, crop failure due to pest attack pushes rural households deeper into debt.
EVOLVING RESEARCH METHOD IN THREE-DIMENSIONAL AND VOLUMETRIC URBAN MORPHOLOGY OF A HIGHLY DENSE CITY: ASSESSING PUBLIC AND QUASI-PUBLIC SPACE TYPOLOGIES
Authors: Choi Hee Sun Sunny , Bruyns Gerhard , Cheng Tian , Xie Jiangtao
Published: March 2024

An appropriate urban density is a vital part of a sustainable urban fabric. However, when it comes to measuring the built urban fabric and how people walk through it and use, a difficulty has been observed in defining applicable measurement tools. With the intention of identifying the variables that will allow the best characterization of this fabric and movement, a multi-variable analysis methodology from the field of artificial intelligence (AI) is proposed. The main objective of this paper is to prove the capacity of AI as an evolving research method in urban morphology and specifically to evaluate the capacity of such a methodology to measure the way in which people travel through defined multi-levels of typologies of public urban space. The research uses the case of Hong Kong as a dense city that is three-dimensionally activated in terms of its public realm, not just at street level, but also via below ground subways and upper-level walkways, public and quasi-public spaces. This includes the three-dimensional volumetric assessment of public and quasi-public space typologies within a highly dense city. For the purpose of the study, a characterization and term definition of these spaces has been further developed: “Junctions”, “Landmarks”, “Intersections”, “Districts”, “Passages” and “Lobbies” (both outdoor and indoor) based on Lynch’s 5 main key elements (District, landmark, path, edges, node). The results obtained using AI prove to be more robust and rational than those based on a more limited range of tools, evidencing that using AI can offer operational opportunities for better understanding of morphological and typological evolution within the vertical and volumetric built urban fabric.
A Revisit of the Mass–Metallicity Trends in Transiting Exoplanets
Authors: Sun Qinghui , Wang Sharon Xuesong , Welbanks Luis , Teske Johanna , Buchner Johannes
Published: March 2024

The two prevailing planet formation scenarios, core accretion and disk instability, predict distinct planetary mass–metallicity relations. Yet, the detection of this trend remains challenging due to inadequate data on planet atmosphere abundance and inhomogeneities in both planet and host stellar abundance measurements. Here we analyze high-resolution spectra for the host stars of 19 transiting exoplanets to derive the C, O, Na, S, and K abundances, including planetary types from cool mini-Neptunes to hot Jupiters (T
eq ∼ 300–2700 K; planet radius ∼0.1–2 R
J). Our Monte Carlo simulations suggest that the current data set, updated based on Welbanks et al., is unable to distinguish between a linear relation and an independent distribution model for the abundance-mass correlation for water, Na, or K. To detect a trend with strong evidence (Bayes factor > 10) at the 2σ confidence interval, we recommend a minimum sample of 58 planets with Hubble Space Telescope measurements of water abundances coupled with [O/H] of the host stars, or 45 planets at the JWST precision. Coupled with future JWST or ground-based high-resolution data, this well-characterized sample of planets with precise host-star abundances constitute an important ensemble of planets to further probe the abundance-mass correlation.