bluuebunny/crossref_metadata_2025 huggingface dataset:
Equivalent health assessment of rotating machinery with imbalance rotor based on metric learning
Authors: Liu Haifei , Tao Laifa , Pu Xuyang , Jin Kaixin , Zhang Tong
Published: June 2022

Imbalanced faults are common and highly harmful faults in the rotating machinery, and the causes of imbalance are various. To better establish a unified cognitive form of imbalance fault health states, a series of experiments are designed to explore the signal changes of the rotating system under different imbalance states, and a Mahalanobis distance (MD) metric learning method based on feature extraction in the time domain and frequency domain is proposed. Finally, the mapping relations between unbalance moments and confidence values (CV) are constructed, which the proposed equivalent health assessment (EHA). The verification results prove that the proposed EHA is effective for accurately knowing the health degree of the given rotating system under imbalance states.
An instantaneous speed measurement method based on A/D acquisition method
Authors: Gu Gaoquan , Zhang Jing
Published: June 2022

The measurement of instantaneous speed is often used in the vibration and noise control of equipment. This paper designs an instantaneous speed measurement method based on A/D sampling method. This method mainly obtains the instantaneous speed indirectly by obtaining the square wave signal. The experimental results show that this method is simple and feasible, and provides a reference for the establishment of instantaneous speed measurement system.
Dynamical stability analysis for a micro shell subjected to swirling annular flow including the coupling effect of small size and fluid rotation
Authors: Chen Cheng , Chen Xinlei , Ning Wenbo , Wu Junzhang , Liu Yuehong
Published: June 2022

This paper is concerned with stability analysis for an outer thin-walled shell conveying a swirling flowing fluid in the annular space between the inner shell and outer shell with micro-dimensions. It describes the development of theoretical model in the framework of the modified coupled stress theory along with the Donnell shell theory. The theoretical model uses the Hamilton’s principle to derive the governing motion equations of the shell. The fluid is assumed to be incompressible and irrotational and the hydrodynamic pressure is considered with the version of the potential flow theory. The zero-level contour method is utilized to display the complex dynamical behaviors of micro shell subjected to swirling annular flow. The effects of the material intrinsic parameter, the fluid rotation on stabilities of the fluid microscale shell system are discussed fully. The results elucidate that the coupling effect of the fluid rotation and the material intrinsic parameter on such system.
Generating various motion paths of single-mass vibratory system equipped with symmetric planetary-type vibration exciter
Authors: Korendiy Vitaliy , Gurey Volodymyr , Borovets Volodymyr , Kotsiumbas Oleh , Lozynskyy Vasyl
Published: June 2022

Vibration exciters are of the most important parts of vibratory technological equipment. Among a great variety of exciters, the inertial ones are currently the most widely used due to their design simplicity, well-studied control techniques, and relatively large efficiency. The present paper deals with a prospective type of inertial exciters based on a planetary mechanism. The main purpose of this research consists in substantiating the possibilities of providing triangular, rectangular, hexagonal, and other paths of oscillations of a single-mass vibratory system driven by a symmetric planetary-type vibration exciter. The mathematical model of the system motion is developed using the Euler-Lagrange equations, and the following numerical modeling is carried out with the help of the Runge-Kutta methods integrated in the Mathematica software. Virtual experiments are conducted in the SolidWorks software using the 3D-model of the vibratory system. The obtained results are presented in the form of time response curves and motion paths of the oscillating body under different operational conditions. The major scientific novelty of the paper consists in substantiating the parameters of the symmetric planetary-type vibration exciter allowing for generating triangular, rectangular, hexagonal oscillations of the single-mass vibratory system. The obtained results can be effectively used while designing new and improving existent vibratory technological equipment, e.g., conveyors, screens, feeders, sieves, etc.
Analysis on structural dynamic characteristics of integrated intelligent tower construction machine under effects of strong winds
Authors: Li Bazhou , Tian Wei
Published: June 2022

In view of the fact that integrated intelligent tower construction machine which is designed to improve the construction efficiency and quality and operating conditions of bridge towers always withstand various wind loads (especially super typhoons or gusts) so that hidden dangers may exist in their structural safety and reliability, their structural dynamic characteristics analysis of effects of strong winds shall be an essential part in their design stage. For this purpose, Davenport wind speed spectra were used to simulate the extreme pulsating wind loads and their structural dynamic wind-induced responses were investigated by means of the finite element method (FEM) to gain the displacement and stress responses of key nodes and then determine their structural design safety. The results show that: the maximum stress and displacement occur in the upper parts of their frames; and the forces and displacement of their structural dangerous positions are within their corresponding safe ranges. Our analysis results can provide a theoretical reference for application and structural optimization of tower machine.
A deconvolution sound source identification method based on twice weak selection orthogonal matching pursuit
Authors: Zhao Weipeng , Mao Jin , Liu Kai
Published: June 2022

The deconvolution sound source identification algorithm based on orthogonal matching pursuit has high identification accuracy and spatial resolution. Still, it has a significant defect in that the sparse degree of sound source needs to be known in advance, so it often has significant limitations in practical engineering applications. In this paper, a deconvolution sound source identification algorithm with twice weak selection orthogonal matching pursuit (TWSOMP-DAMAS) is proposed. It can delete the wrong atoms according to twice weak selection criteria in the iterative process, gradually narrow the range of sound sources, and finally find the location of real sound sources. The simulation results show that the TWSOMP-DAMAS algorithm can effectively reduce the main lobe width and has a higher spatial resolution than the deconvolution algorithm with sparse constraints (SC-DAMAS). And the deconvolution sound source identification algorithm with orthogonal matching pursuit (OMP-DAMAS) has the same identification effect; The TWSOMP-DAMAS algorithm is proved to have good adaptability to noise environment, and the recognition results show that the algorithm has high recognition stability.
Experimental investigation of kinematic characteristics of a wheeled vibration-driven robot
Authors: Korendiy Vitaliy , Kachur Oleksandr , Gursky Volodymyr , Gurey Volodymyr , Pelio Roman , Kotsiumbas Oleh
Published: June 2022

The presented research continues the authors’ previous investigations on the dynamics of a wheeled vibration-driven robot. The main purpose of this paper consists in conducting the experimental studies of the robot motion conditions. The methodology of research is divided into three basic stages: designing the 3D-model of the robot in the SolidWorks software and implementing its experimental prototype; experimental studying the motion conditions and carrying out the corresponding measurements; analyzing the obtained results and forming the conclusions. The main findings (results) are presented in the form of time response curves of the basic kinematic characteristics of the robot motion: displacements, velocities, and accelerations of the robot’s wheeled platform and of the disturbing (impact) body. The novelty of this research consists in substantiating the possibilities of applying the vibro-impact working regimes to improve the kinematic characteristics and operational efficiency of the wheeled vibration-driven robot. The obtained results can be profitably used by designers and researchers of mobile locomotion systems, particularly those for inspecting the pipelines.
Network Pharmacology-based Strategy to Investigate Pharmacological
Mechanisms of Qingbutongluo Pill for Treatment of Brucellosis
Authors: Zhou Wei-Gang , Wang Jing , He Jia-Wei , Liu Ji-Shan , Li Jian-E , Cui Qing-You , Wang Yi-Rui
Published: June 2022

Background and Objectives:

Qingbutongluo pill (QBTLP), a Chinese herbal preparation,
has been developed to treat brucellosis for many years with a good therapeutic effect. This
study preliminarily explored its potential molecular mechanisms against brucellosis through network
pharmacology.

Methods:

The active ingredients of QBTLP were screened out mainly from the Traditional Chinese
medicine systems pharmacology database and analysis platform (TCMSP), and their potential
targets were predicted through the PubChem database and Swiss Target Prediction platform.
GeneCards, DisGeNET， Digsee， and the Comparative Toxicogenomics Database (CTD) searched
the targets corresponding to brucellosis. Then, the Venn diagram obtained intersection targets of
QBTLP and diseases. Protein-protein interaction (PPI) network analysis was performed using the
Search Tool for the Retrieval of Interacting Genes database (STRING) and visualized in Cytoscape
software. Module analysis of the PPI network and core target identification was performed using
the Molecular Complex Detection (MCODE) and the Cytohubba plugins. The Metascape data platform
was used to perform Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes
(KEGG) pathway enrichment analysis on the intersection targets, and then the “active ingredientstargets-
pathways” network was constructed using Cytoscape to screen key active ingredients.

Results:

19 key active ingredients were identified by network pharmacological, including Baicalein,
Cryptopin, etc. The core targets of QBTLP for treating brucellosis contained TNF, TLR4,
MAPK3, MAPK1, MAPK8, MAPK14, MMP9, etc. And the main pathways included the Toll-like
receptor signaling pathway, NOD-like receptor signaling pathway, TNF signaling pathway, MAPK
signaling pathway, Th17 cell differentiation, and IL-17 signaling pathway.

Conclusions:

This study explored the mechanisms of QBTLP for treating brucellosis, which may
provide a scientific basis for the clinical application of QBTLP.
Saikosaponin-A Exhibits Antipancreatic Cancer Activity by Targeting the
EGFR/PI3K/Akt Pathway
Authors: Li Qiang , Shi Chengda , Sun Linglin , Fang Rong , Zheng Shuying , Yu Mingming
Published: June 2022

Background:

A diagnosis of pancreatic cancer is pretty grim. Saikosaponin-A (SSA) is
a Chinese herbal extract with anticancer activity. However, the therapeutic effect of SSA on pancreatic
cancer remains elusive.

Aim:

The study aims to evaluate the antitumor effects of SSA on pancreatic cancer cells in vitro
and in vivo.

Methods:

After treatment with SSA, cell viability was measured using the CCK-8 assay, DAPI
staining was performed to analyze the effect on nuclear morphology, propidium iodide (PI) staining
was used to detect the cell cycle, and Annexin V/PI double staining was conducted to analyze
apoptosis. Then, the expression of apoptosis-related proteins and EGFR/PI3K/Akt pathway-related
proteins was determined using western blotting. The binding of SSA to EGFR was analyzed by
performing molecular docking. The mouse pancreatic cancer model was established by subcutaneously
injecting pancreatic cancer cells, and after 30 days of SSA gavage, the tumor volume was
calculated. Tumor tissue sections were subjected to Ki67 immunohistochemical staining and HE
staining.

Results:

SSA inhibited the proliferation of pancreatic cancer cells. As the concentration of SSA
increased, the proportions of BxPC-3 and MIA PaCa-2 cells in the G0/G1 phase increased, the
proportions of early and late apoptotic cells also increased, and the apoptosis rate gradually increased.
Apoptosis inhibitor experiments indicated that SSA promoted the activation of caspase 3
to induce apoptosis in pancreatic cancer cells. In addition, SSA treatment significantly reduced the
levels of phosphorylated EGFR, Akt, and PI3K in the two cell lines. Molecular docking results
showed that SSA may have potential binding sites in EGFR. Results of the xenograft experiment
confirmed the antitumor effects of SSA, as evidenced by the decreased tumor weight and downregulated
expression of Ki67.

Conclusions:

The results revealed that SSA exerted inhibitory effects on pancreatic cancer cells.
These effects may be related to the inactivation of the EGFR/PI3K/Akt signalling pathway.
Metabolic Syndrome in Behçets Disease Patients: Keep an Eye on the Eye
Authors: Gheita Tamer A. , ElAdle Suzan S. , Latif Eiman Abdel , Abdel-Fattah Yousra H. , Shebini Emad El , El-Gazzar Iman I. , El-Saadany Hanan M. , Samy Nermeen , El-Mallah Reem , Salem Mohamed N. , Eesa Nahla , Shereef Rawhya El , El Khalifa Marwa , Tharwat Samar , Nasef Samah I. , Ibrahim Maha Emad , Khalil Noha M. , Abdalla Ahmed M. , Abd Elazeem Mervat I. , Noor Rasha Abdel , Sallam Rehab , El-Bahnasawy Amany , Shanawany Amira El , Senara Soha , Fathi Hanan M. , Bakry Samah A. El , Elsaman Ahmed , Najjar Amany El , Ragab Usama , Talaat Esraa A. , Hammam Nevin , El-Hindawy Aya K. , Ismail Faten
Published: June 2022

Background:

Metabolic syndrome (MetS) is characterized by insulin resistance, high blood pres-sure/sugar, dyslipidemia, and obesity. Whether MetS and its components affect the development of Behçet's Disease (BD) remains unclear.

Aims:

The aim was to determine the frequency of MetS among BD patients and to study its relationship with disease characteristics.

Methods:

The study included 1028 adult BD patients recruited from 18 specialized rheumatology centers. 51 healthy matched control were considered. Behçet Disease Current Activity Form (BDCAF) and the BD damage index (BDI) were estimated. Adult Treatment Panel-III criteria were used to define MetS.

Results:

The mean age of patients was 36.8 ± 10.1 years, M:F 2.7:1 and disease duration 7.01 ± 5.2 years. Their mean BDCAF was 5.1 ± 4.6 and BDI 5.5 ± 2.8. MetS was present in 22.8% of patients and in 5.9% of control (3.9 fold higher-risk). Patients with MetS had a significantly increased age at onset (31.8 ± 9.2 vs. 29 ± 8.5 years) and higher frequency of genital ulcers (96.2% vs. 79.7%), skin involvement (73.1% vs. 50.4%), arthritis (48.3% vs. 29.1%) (p<0.0001) and CNS manifestations (18.8% vs. 13%) (p=0.042) compared to those without it. Eye involvement was significantly increased in those with MetS (82.1% vs. 74.2%) (p=0.003) with increased frequency of posterior uveitis (67.1% vs. 43.5%), retinal vessel occlusion (35.9% vs. 21.3%), retinal vasculitis (41.9% vs. 26.4%) (p<0.0001) and vitritis (37.2% vs. 24%) (p=0.001). BDCAF was significantly lower (3.9 ± 4.3 vs. 5.6 ± 4.6) and BDI higher (7.4 ± 2.7vs5 ± 2.6) (p<0.0001).

Conclusion:

BD patients with MetS are predisposed to mucocutaneous, musculoskeletal, neuropsychiatric and ocular manifestations with consequently increased damage. The involvement of the deeper structures of the eye should alarm rheumatologists to keep in mind that all patients should have an eye examination, especially those with MetS.
A Case of Wild-type Cardiac Transthyretin Amyloidosis Diagnosed by
Non-invasive Methods
Authors: Lizarazo Ortega David Andrés , Valderrama Bibiana Pinzón , González-Robledo Gina , Trujillo Patricia Bernal
Published: June 2022

Introduction:

Transthyretin amyloid cardiomyopathy was considered a rare pathology.
However, recent studies show a significant prevalence in patients with degenerative aortic stenosis and
heart failure with preserved ejection fraction.

Case Presentation:

An 85-year-old woman presented with a four-month history of pain in the rib cage
with a history of diffuse large B-cell lymphoma of the oral cavity, essential thrombocytosis and
dyslipidemia. She had no significant family history. A transthoracic echocardiogram showed
degenerative aortic stenosis and normal systolic function with preserved left ventricular ejection
fraction of 70%. Bone-avid tracer cardiac scintigraphy with technetium-99m-labeled hydroxymethylene
diphosphonate with SPECT-CT documented grade two myocardial uptake according to the
Perugini scale. MRI evidenced late patchy enhancement in the myocardium associated with diffuse
subendocardial enhancement. Laboratory tests showed the absence of mutation in the transthyretin
(TTR) gene, serum and urine immunofixation electrophoresis (IFE) negative for monoclonal protein
and serum-free light chain (sFLC) assay with a normal kappa/lambda (K/L) ratio. All these findings
were compatible with a non-invasive diagnosis of wild-type cardiac amyloidosis.

Conclusion:

The accepted criteria for the definitive non-invasive diagnosis of amyloid
cardiomyopathy are based on myocardial uptake by scintigraphy (with SPECT), serum and urine
immunofixation electrophoresis, serum-free light chain assay and suggestive findings on
echocardiography and/or MRI. Genetic testing should differentiate between ATTRv (v for variant) and
ATTRwt (wt for wild type) forms.
Simple and Rapid LC-MS/MS Method for Determination of Perampanel
in Human Plasma and Application to Bioequivalence Study
Authors: Zou Qiao-gen , Gao Pan
Published: June 2022

Background:

Perampanel (PER) is a third-generation antiepileptic drug (AED). Several
methods have been developed for the quantification of perampanel in plasma. The pharmacokinetic
characteristics of perampanel in healthy Chinese ubjects have not been comprehensively
reported.

Objective:

A simple, fast and sensitive LC-MS/MS method was established and validated for the
quantification of perampanel in human plasma and its application to a bioequivalence study.

Methods:

Chromatographic separation was accomplished on a ZORBAX Eclipse XDB-Phenyl
column (4.6 mm × 75 mm, 3.5 μm) using a binary gradient with mobile phase (A) (water containing
5 mmol/L ammonium acetate and 0.1% formic acid and (B) acetonitrile-water (95:5, v/v) at a
flow rate of 0.9 mL/min and sample preparation was by one-step protein precipitation via acetonitrile.

Results:

The total run time in this study was 4.5 min and the retention time of perampanel and
perampanel-d5 (internal standard) were 2.30 min and 2.32 min, respectively. The method was developed
and validated over the concentration range of 2.00-500 ng/mL for perampanel, with a
correlation coefficient greater than 0.9992. The inter-day precision was 3.1%-3.8% and accuracy
was 98.9%-103.5%. The intra-day precision was 2.4%-6.8% and the accuracy was 97.6%-
104.9%. The extraction recovery ranged from 99.23%-103.84% and the matrix effect was not
significant. Perampanel was proved to be stable in solution and human plasma under different
tested conditions. The validated method was successfully applied to a randomized, open-label, 2-
period, crossover bioequivalence study in healthy Chinese subjects, and the results indicated that
bioequivalence was achieved for 2 formulations of the 4-mg perampanel tablet under both fasting
and fed conditions, and both treatments were safe and well-tolerated by all study subjects.

Conclusion:

The validated method was successfully applied to a bioequivalence study of perampanel
in human plasma and has achieved satisfactory results.
Successful Pre-Clinical Management of Irinotecan-Debilitated Animals: A Protein-
Based Accessory Phytomedicine
Authors: Rangel Gisele F. P. , Ramos Márcio V. , do Carmo Luana D. , Rabelo Liviane M. A. , Silva Alfredo A. V. , de Sousa Tamiris F. G. , Lima Júnior Roberto C. P. , Wong Deysi V. T. , Leitão Renata F. C. , Magalhães Pedro J. C. , Sousa Brandon F. , Frederico Marisa J. S. , Alencar Nylane M. N.
Published: June 2022

Background:

Calotropis procera is a laticiferous plant (Apocynaceae) found in tropical regions all over the
world. The ultrastructural characteristics of laticifers, their restricted distribution among different taxonomic groups,
and in some species in each clade, as peptidases from latex, make them very attractive for biological analysis.

Objective:

The study aims to investigate the effects of LP-PII-IAA (laticifer protein (LP) sub-fraction II (PII) of C.
procera presenting an iodoacetamide-inhibited cysteine proteinase activity) on irinotecan-induced intestinal mucositis,
a serious adverse effect of this medicine for the treatment of cancer.

Methods:

LP-PII-IAA is composed of closely related isoforms (90%) of peptidases derived from catalysis and an osmotin
protein (5%). Animals receiving co-administration of LP-PII-IAA presented a significant decrease in mortality,
absence of diarrhea, histological preservation, and normalization of intestinal functions.

Results:

Clinical homeostasis was accompanied by a reduction in MPO activity and declined levels of IL-1β, IL-6 and
KC, while the IL-10 level increased in LP-PII-IAA-treated animals. COX-2 and NF-kB immunostaining was reduced
and the levels of oxidative markers (GSH, MDA) were normalized in animals that received LP-PII-IAA.

Conclusion:

We suggest that peptidases from the latex of Calotropis procera were instrumental in the suppression of
the adverse clinical and physiological effects of irinotecan.
An Analytical Model of Multi-intrusion Detection for Heterogeneous Wireless
Sensor Networks Applied in the Monitoring Area
Authors: Assad Noureddine , Moujahdi Chouaib , Hannani Asmaa El , Hanine Mohamed , Lachgar Mohamed
Published: June 2022

Aim:

For a Wireless Sensor Network (WSN), the sensor node deployment is a critical issue
since it reflects the coverage quality. It is the most fundamental issue in WSNs, and it has a great effect
on the overall WSN application performance. When it is necessary to deploy randomly sensor
nodes in a field of interest to form a WSN, ensuring a high coverage quality becomes difficult. In the
random deployment scenario, the most difficult aspect of sensing coverage is to find how well the
sensor nodes cover the field of interest. In this paper, we analyze the intrusion detection in a WSN
which is defined as a mechanism for monitoring and detecting any intruder in a field of interest, with
the objective of enhancing the detection quality in a random WSN. It is required to establish more
specific measurements of node density and sensor range that impact the overall system performance
especially in the intrusion detection application. To enhance the quality of intrusion detection, several
probabilistic models are adopted for heterogeneous WSN in the random deployment scenario.

Methods:

Multi-intrusion detection model probability in a heterogeneous wireless sensor network for
random deployment was used.

Results and Discussion:

In both homogeneous and heterogeneous WSNs, we analyzed our probabilistic
model for multi-intrusion detection in single and multi-sensing detection.

Conclusion:

Our probabilistic models are useful in selecting the critical parameters of WSN in order
to meet the detection quality requirement.
A Novel Construction Method of (OP) Polynomial and Rational Fuzzy
Implications
Authors: Papadopoulos Basil K. , N. Rapti Maria
Published: June 2022

In this article, we develop new constructed methods with specific conditions. The first
method is a generalization of convex combination using n fuzzy implications. The second method
is a parameterization of Lukasiewicz implication in an Ordering Property (OP) fuzzy implication
form. The innovation in this work is the presentation of three new constructed methods of (OP)
polynomial and (OP) rational fuzzy implications. We investigate some families of Ordering Property (OP) and Ordering Property (OP) Rational fuzzy implications. To these methods, we give
some coefficient conditions in order to satisfy basic properties like ordering property (OP), identity
property (IP) and contrapositive symmetry (CP).

Background:

Fuzzy implication functions are one of the main operations in fuzzy logic. They generalize the classical implication, which takes values in the set {0, 1}, to fuzzy logic, where the truth
values belong to the unit interval [0, 1]. The study of this class of operations has been extensively
developed in the literature in the last 30 years from both theoretical and applicational points of
view.

Introduction:

In this paper, we develop five new methods for constructing fuzzy implications with
specific properties. The paper starts by presenting the first fuzzy implication construction machine
that uses n fuzzy implications with specific conditions. Next, we parameterize Lukasiewicz implication and create new families of (OP) polynomial and (OP) rational implications. For each method
we investigate which conditions are satisfied and we give some examples.

Methods:

The first constructed method uses n fuzzy implications in a linear product representation.
The second method is an (OP) polynomial implication a parameterized Lukasiewicz implication.
The third method is a rational implication with five parameters. In the fourth method we give a
general form in the previous method by changing variables x and y with increasing functions. Finally, the last method is another (OP) rational implication with three parameters.

Results:

In each method we present the properties that are satisfied. We generalize the (OP) polynomial and rational by replacing the variables with monotonic functions or add powers on them.
Finally, we generalize and we give examples of new produced fuzzy implications.

Conclusion:

As a future work, we can create new families of rational implications by changing the
polynomials of the numerator and denominator so that they satisfy more properties. Finally, the
new methods we presented can contribute in the construction of uninorms and copulas under certain conditions.
Clinical Studies that Initiated the Use of Spinal Opioids for the Treatment
of Pain: A New Approach to Historical Review
Authors: Kissin Igor
Published: June 2022

Opioids administered into the spinal space by intrathecal or epidural routes can provide potent
and prolonged selective analgesia. Compared to the systemic administration of opioids, spinal
administration can bring about analgesia with fewer central and systemic adverse effects. For the past
40 years, spinal opioid analgesia has achieved great popularity in various fields of pain treatment. The
aim of this work is to identify clinical studies that initiated the use of spinal opioids for the treatment
of pain.

:

To determine the historical role of each of the review’s studies, we used the combination of two factors:
the study priority in terms of the time of its publication and the degree of its acknowledgement in
the form of citation impact. The date of publication was regarded as the primary factor, but only if the
count of citations indicated a sufficient acknowledgement by the other authors. The citation impact
was assessed as the initial citation count – for a period of five years after the year of article publication
– and the total count.

:

Analysis of the related data shows that the clinical studies initiating the use of spinal opioids for the
treatment of pain belong to two groups of authors – Wang et al. and Behar et al. Both studies were
published in 1979 and described delivery of morphine into the spinal space, although the techniques of
administration were different: Wang et al. injected morphine intrathecally, Behar et al. administered
morphine epidurally. The response to these studies was overwhelming - close to a dozen reports on
this topic were published in 1979 and more than a hundred – in 1980-1981. The total citation response
to the Wang et al. article reached 699, and that to Behar et al. – 518. Two earlier records (1900-1901)
of the use of intrathecal morphine, by Nicolae Racoviceanu-Pitesti and Otojiro Kitagawa, found no
following in medical literature for more than three quarters of a century.
Effect of Virtual Reality Hypnosis on Pain Threshold and Neurophysiological and Autonomic Biomarkers in Healthy Volunteers: Prospective Randomized Crossover Study
Authors: Terzulli Claire , Melchior Meggane , Goffin Laurent , Faisan Sylvain , Gianesini Coralie , Graff Denis , Dufour André , Laroche Edouard , Chauvin Chloé , Poisbeau Pierrick
Published: June 2022

Background

Virtual reality hypnosis (VRH) is a promising tool to reduce pain. However, the benefits of VRH on pain perception and on the physiological expression of pain require further investigation.

Objective

In this study, we characterized the effects of VRH on the heat pain threshold among adult healthy volunteers while monitoring several physiological and autonomic functions.

Methods

Sixty healthy volunteers were prospectively included to receive nociceptive stimulations. The first set of thermal stimuli consisted of 20 stimulations at 60°C (duration 500 milliseconds) to trigger contact heat evoked potentials (CHEPs). The second set of thermal stimuli consisted of ramps (1°C/second) to determine the heat pain threshold of the participants. Electrocardiogram, skin conductance responses, respiration rate, as well as the analgesia nociception index were also recorded throughout the experiment.

Results

Data from 58 participants were analyzed. There was a small but significant increase in pain threshold in VRH (50.19°C, SD 1.98°C) compared to that in the control condition (mean 49.45°C, SD 1.87; P<.001, Wilcoxon matched-pairs signed-rank test; Cohen d=0.38). No significant effect of VRH on CHEPs and heart rate variability parameters was observed (all P>0.5; n=22 and n=52, respectively). During VRH, participants exhibited a clear reduction in their autonomic sympathetic tone, as shown by the lower number of nonspecific skin conductance peak responses (P<.001, two-way analysis of variance; n=39) and by an increase in the analgesia nociception index (P<.001, paired t-test; n=40).

Conclusions

The results obtained in this study support the idea that VRH administration is effective at increasing heat pain thresholds and impacts autonomic functions among healthy volunteers. As a nonpharmacological intervention, VRH has beneficial action on acute experimental heat pain. This beneficial action will need to be evaluated for the treatment of other types of pain, including chronic pain.
Development of an Assistive Technology for Cognition to Support Meal Preparation in Severe Traumatic Brain Injury: User-Centered Design Study
Authors: Pinard Stéphanie , Bottari Carolina , Laliberté Catherine , Pigot Hélène , Olivares Marisnel , Couture Mélanie , Aboujaoudé Aline , Giroux Sylvain , Bier Nathalie
Published: June 2022

Background

Although assistive technology for cognition (ATC) has enormous potential to help individuals who have sustained a severe traumatic brain injury (TBI) prepare meals safely, no ATC has yet been developed to assist in this activity for this specific population.

Objective

This study aims to conduct a needs analysis as a first step in the design of an ATC to support safe and independent meal preparation for persons with severe TBI. This included identifying cooking-related risks to depict future users’ profiles and establishing the clinical requirements of the ATC.

Methods

In a user-centered design study, the needs of 3 future users were evaluated in their real-world environments (supported-living residence) using an ecological assessment of everyday activities, a review of their medical files, a complete neuropsychological test battery, individual interviews, observational field notes, and log journals with the residents, their families, and other stakeholders from the residence (eg, staff and health professionals). The needs analysis was guided by the Disability Creation Process framework.

Results

The results showed that many issues had to be considered for the development of the ATC for the 3 residents and other eventual users, including cognitive issues such as distractibility and difficulty remembering information over a short period of time and important safety issues, such as potential food poisoning and risk of fire. This led to the identification of 2 main clinical requirements for the ATC: providing cognitive support based on evidence-based cognitive rehabilitation to facilitate meal preparation and ensuring safety at each step of the meal preparation task.

Conclusions

This needs analysis identified the main requirements for an ATC designed to support meal preparation for persons with severe TBI. Future research will focus on implementing the ATC in the residence and evaluating its usability.
El león durmiente. Democracia, republicanismo y federalismo en España, 1812-1936
Authors: Suárez Cortina Manuel
Published: June 2022

"The Sleeping Lion" brings us closer to the historical struggle between the liberal and republican projects for the construction of the State and the nation in the Spain that we generically know as liberal. From the cultural history of politics we offer a look at the way in which liberalism, republicanism and democracy struggled to establish their dominance from their own narratives and from the different configuration of political institutions. Hence, the distinction between different modalities of liberalism, democracy, republic and federalism is a central ingredient of its pages. For, indeed, there was not only a confrontation between liberalism and monarchy, on the one hand, and between republicanism, federalism and democracy, on the other. As can be seen throughout the book, there were various ways of being liberal, republican and democrat, in such a way that the opposition between a centralist and monarchical liberalism versus a federal republicanism would be but the most generic aspect of a plurality of social, cultural and political registers that were emerging since the mid-nineteenth century and extended over a century.
Gambaran Efektivitas Pembelajaran dalam Jaringan Mahasiswa Program Studi Keperawatan Universitas Jambi selama Pandemi COVID-19
Authors: Mekiza Rhetiya , Mawarti Indah , Imran Suryadi
Published: June 2022

Most of the world has been hit by the Covid-19 pandemic, one of which is Indonesia. The government implemented a policy to learn from home, resulting in the change of the learning system that is usually face-to-face to remote using the online learning system. Therefore, it is necessary to know the effectiveness of the online learning process during the Covid-19 pandemic. To know the description of the effectiveness of online learning during the pandemic Covid-19 at the nursing students Universitas Jambi. This research used descriptive method and the data obtained in the survey. The subject of this research is students of 2017 - 2020 in the Study Programme of Keperawatan UNJA. The study samples are 152 students. The used instrument is the standard quality of the online learning process SPADA 2019 by the ministry of education.
Based on the results, the online learning process of Nursing students at UNJA is quite effective. It comprises aspects of learning planning and learning strategies within the category of very effective, while the learning activity, learning media and technology, learning support service as well as learning evaluation aspects is quite effective. The online learning process of UNJA Nursing students categorized as quite effective.
 Keywords: Effectiveness, Online Learning
Abstrak
Sebagian besar dunia telah dilanda pandemi Covid-19 salah satunya indonesia. Pemerintah menerapkan kebijakan belajar dari rumah, mengakibatkan diubahnya sistem pembelajaran yang biasanya tatap muka menjadi jarak jauh menggunakan sistem pembelajaran daring. Sehingga berdasarkan hal tersebut perlu diketahui efektivitas proses pembelajaran secara daring saat pandemi Covid-19. Untuk mengetahui gambaran efektivitas pembelajaran daring selama masa pandemic Covid-19 pada mahasiswa keperawatan Universitas Jambi. Penelitian ini menggunakan metode deskriptif dan data diperoleh secara survei. Subjek penelitian ini adalah mahasiswa angkatan 2017 - 2020 di Program Studi Keperawatn UNJA. Sampel penelitian ini sebanyak 152 orang mahasiswa. Instrumen yang digunakan adalah standar mutu proses pembelajaran daring SPADA 2019 oleh Kemenristekdikti. Berdasarkan hasil penelitian, proses pembelajaran daring mahasiswa Keperawatan UNJA tergolong cukup efektif. Hal ini meliputi aspek perencanaan pembelajaran dan strategi pembelajaran berada pada kategori sangat efektif, sedangkan aspek kegiatan pembelajaran, media dan teknologi pembelajaran, layanan bantuan belajar, serta evaluasi pembelajaran berada pada kategori cukup efektif. Proses pembelajaran daring mahasiswa Keperawatan UNJA masuk dalam kategori cukup efektif.
Kata Kunci: Efektivitas, Pembelajaran Daring
Gambaran Kesiapsiagaan Masyarakat dalam Antisipasi Bencana Banjir Di Kecamatan Danau Kerinci Barat Kabupaten Kerinci
Authors: Gustini Sri , Subandi Andi , Oktarina Yosi
Published: June 2022

Flood disaster is one of the biggest disasters in the world. It is hoped that the readiness and knowledge of the community in dealing with floods is expected to be proactive in being able to take preventive, emergency response and rehabilitation measures in collaboration with the government to maintain the environment that can cause flooding in order to minimize the impact it causes. The magnitude of the potential for flooding in Kerinci prompted the need for community preparedness measures to reduce losses due to these impacts. This study aims to determine the description of community preparedness in anticipation of flood disasters in Danau Kerinci Barat District, Kerinci Regency. This type of research used a quantitative descriptive design. This research was conducted in 5 villages located in the West Lake Kerinci District, namely, the villages of Tanjung Pauh Mudik, Pancuran Tiga, Punai Merindu, Bukit Pulai and Sumur Jauh. The population of all family heads in the 5 villages was 1,580 with a sample size of 110 samples. Technique Sampling used Cluster Random Sampling The results showed the parameters of knowledge are classified as very ready, the parameters for policies and guidelines are not ready, the parameters for the emergency response plan are classified as less ready, the parameters for disaster warning are classified as less ready, and the parameters for resource mobilization are classified as not ready. It can concluded that the description of community preparedness in anticipation of flood disasters in Danau Kerinci Barat District, Kerinci Regency is classified as almost ready.
PENGELOLAAN SAMPAH BERBASIS SEKOLAH DASAR DENGAN PENDEKATAN KOMPOSTING TAKAKURA DI KOTA JAMBI
Authors: Amir Andy , Guspianto Guspianto , S Oka Lesmana
Published: June 2022

Community service has been carried out at the Paal X Health Center in Jambi City, which is a partner of FKM Unja to conduct socialization and training on organic waste management to elementary school teachers and students in the Puskesmas working area. Implementation of five months of service from July to November 2019. The aim is to increase awareness and motivation of elementary school teachers on the importance of empowering students to process waste in the school environment. This service method is a socialization of school-based waste management and training in processing organic waste into compost fertilizer. The results of this service are increasing teacher understanding after getting school-based waste management socialization and teachers and students are able to process organic waste into compost using the Takakura method after get training on compost making. Making compost using materials and tools that are easily available include: basket, cardboard, rice husk pillow, soil as a starter, EM4 bioactivator to accelerate decomposition, and wet and dry organic waste collected by students from the school environment. School-based waste management must have the support of leadership policies so that it can be implemented sustainably so as to reduce waste generation in the environment.
PENDAMPINGAN LANSIA MELALUI KEGIATAN SENAM LANSIA SEBAGAI UPAYA PENINGKATAN KESEHATAN FISIK DAN PSIKIS LANSIA DI POSYANDU RT 01 DAN RT 02 KELURAHAN LINGKAR SELATAN KECAMATAN PAAL MERAH TAHUN 2020
Authors: Noerjoedianto Dwi , Mekarisce Arnild Augina , Ivanti Risty , Rini Willia Novita Eka , Putri Fitria Eka
Published: June 2022

Elderly is a period when organisms have reached their prime in size, function, and some have shown their decline over time. Based on the indicators of physical fitness in the elderly in Indonesia, it is still lacking, this is proven by the high morbidity rate in the elderly. To be able to face the elderly who can enjoy their life and maintain their strength and fitness, the elderly must do regular sports activities, carry out a healthy lifestyle, take a break from smoking and have health checks. This community service aims to improve the physical and psychological health of the elderly through exercise assistance activities for the elderly. This activity is in partnership with RT 01 and RT 02 Kelurahan Lingkar Selatan, Paal Merah District. This activity involves all elderly who are registered in the posyandu as a target of improving physical and psychological health through elderly exercise. Activities are carried out from compiling an activity plan to monitoring and evaluating activities according to the set targets and outputs. The results of the pre-test and post-test activities, which consisted of four indicators of evaluation, had increased, but this was not too significant because this activity only took place during service activities, to find maximum results, it was necessary to sustain the activity. Increased knowledge of the RT elderly group. 01 and RT. 02 Kelurahan Lingkar Selatan on the importance of Lansi Gymnastics in maintaining physical and psychiatric health and Increasing awareness and skills of the elderly group RT. 01 and RT. 02 Lingkar Selatan Village in doing elderly gymnasticsArtikel
A Fractional Cubic Spline for Solving Fractional Volterra-Integral Equations with Convergence Analysis
Authors: Jaza Rahel , Hamasalh Faraidun
Published: June 2022

n this work, we present a new boundary conditions for fractional cubic
spline (FCS) model for solving fractional Volterra-integral equations.
We reduced the problem to a set of a linear systems by using fractional
continuity conditions. Convergence analysis proved to solve fractional
Volterra-integral equations by obtained linear systems, to determine
fractional spline derivatives, we applied the Caputo fractional
derivative. The process is detailed and computed with three
computational examples, and the results show that it is both effective
and simple to use. Moreover, the results are compared with the methods
in [1 ], [ 2 ] and [4].
Ana o 3 sIgE and diagnostic algorithms reduce cost of cashew allergy diagnosis in children compared to skin prick test: a cost comparison analysis
Authors: Brettig Tim , Dalziel Kim , Koplin Jennifer , Dang Thanh , Lange Lars , William Vicki Mc , Sato Sakura , Savvatianos Savvas , Perrett Kirsten
Published: June 2022

Background: In the absence of a clear clinical history of
reaction, diagnosis of cashew allergy using skin prick tests (SPT) or
cashew-specific IgE requires a high number of oral food challenges
(OFC). By using Ana o 3 sIgE alone, or a two-step diagnostic algorithm
using cashew sIgE followed by Ana o 3 sIgE, there is a reduced need for
OFC. We aimed to perform a cost comparison for both of these approaches
compared to cashew SPT alone. Methods: Pooled individual level
data from 6 studies was used to determine diagnostic accuracy and OFC
rate. Two studies used cashew SPT (n=567, 198 allergic), with 95%
positive and negative predictive values of ≥12mm and <3mm.
Four studies were included in the pathways for Ana o 3 sIgE alone or a
2-step algorithm incorporating cashew and Ana o 3 sIgE (n=271, 156
allergic). Cut-offs used were ≥8.5kUA/L and ≤0.1kUA/L for cashew sIgE
and ≥0.35kUA/L and ≤0.1kUA/L for Ana o 3 sIgE. Costs were constructed
based on unit prices from hospital inpatient admissions, expenses
incurred by families, individual patient data on allergic reaction types
and rates and adrenaline autoinjector carriage, applying a health system
perspective. Results: Modelled data through the Ana o 3 pathway
resulted in a 46.43% cost reduction (\euro307,406/1000
patients) compared to using cashew SPT alone
(\euro573,854/1000 patients). The 2-step algorithm
resulted in a 44.94% cost reduction compared to SPT alone
(\euro315,952.82/1000 patients). Both the Ana o 3 pathway
and 2-step algorithm resulted in a 79-80% reduction in OFCs compared to
SPT. Conclusions: Using Ana o 3 as a standalone test for cashew
allergy diagnosis or a 2-step algorithm incorporating cashew sIgE and
Ana o 3 sIgE is accurate and results in a large reduction in both OFCs
and health system costs compared to cashew SPT alone.
An Improved Protection Circuit Design for Fast Detection of Short-circuit in IPM
Authors: Meng Zhaoliang , Hu Mengyang , Gao Yong , Wang Zisheng , Yang yuan
Published: June 2022

A Short-circuit protection plays a vital role in the overall reliability
of intelligent power module(IPM), and where the shorter the duration of
short-circuit fault, the smaller the impact on the module. The
conventional VCE(sat) detection circuit suffers from a blanking time
problem, and thus to solve this problem, this paper aims to improve the
IPM short-circuit fast detection and protection circuit with integrated
shunts, to achieve the ultra-fast detection and protection of IPM
short-circuit faults. For the improved circuit, the selection method for
the component parameters of a compensation link of the improved circuit
is proposed, and the functions for the remaining parts in the circuit
are introduced. Finally, through experiments, it is verified that the
improved circuit can quickly detect various short-circuit faults, and
correspondingly start shutting down the switching tube at 490ns.
Compared with the conventional method, the detection time of the
proposed method and short-circuit loss for modules under different
short-circuit faults are significantly reduced.
Immediate improvement in GCS following needle aspiration of bilateral traumatic subdural effusion in a child in emergency room
Authors: Khizar Ahtesham , Yadav Pradhumna
Published: June 2022

A child had been vomiting, convulsing, and having an abnormal sensorium
for 3 days. He fell from his mother’s lap 20 days back. On CT scan
brain, he had traumatic subdural effusion. In the emergency room, he
underwent subdural effusion needle aspiration, which resulted in an
immediate improvement in GCS.
Type II endoleak in Thoraflex hybrid stent-graft for frozen elephant trunk operation
Authors: Luthra Suvitesh , Tsang Geoff
Published: June 2022

We describe conservative management of a rare type IIa endoleak after
frozen elephant trunk operation with hybrid Thoraflex stent graft in
chronic type B aortic dissection repair.