bluuebunny/crossref_metadata_2025 huggingface dataset:
Análisis retrospectivo de perfil microbiológico y resistencia antimicrobiana en infección urinaria pediátrica de hospitales públicos de Quito-Ecuador
Authors: MendietaTello Ivonne , Arnao Noboa Adriana , Calderón Robalino Diana , Gea Izquierdo Enrique
Published: June 2023

Objetivo: Determinar el perfil microbiológico y susceptibilidad antimicrobiana en infección urinaria en niños, y uso de medicamentos eficaces. Materiales y métodos: Estudio descriptivo, transversal, observacional y multicéntrico. Se estudiaron 445 urocultivos procesados y los resultados de antibiogramas en tres hospitales públicos de Quito (Ecuador). En relación con los agentes causales se establecieron frecuencias absolutas y proporciones. En el análisis bivariable entre el antecedente de malformación renal o de la vía urinaria y el riesgo de infección, se aplicó el test Chi2 (p < 0,05) y la RP [IC 95 %; p < 0,05]. Resultados: Se evidenció una resistencia ante aminopenicilinas del 73,5 %, ampicilina más sulbactam 31,8 %, trimetoprim-sulfametoxazol 55,5 %, cefalosporinas de primera y segunda generación hasta 33 %, cefalosporinas de tercera y cuarta generación del 21,3 al 47 %. Ante malformación urinaria y aislamiento de bacterias diferentes a Escherichia coli, se identificó a Klebsiella pneumoniae RP 2,66 [IC 95 %, 1,9-3,6; p < 0,05] y Pseudomonas aeruginosa RP 2,07 [IC 95 %, 1,2-3,5; p < 0,05]. Conclusiones: En nuestro medio, ante el diagnóstico de infección urinaria, no parece adecuado iniciar tratamiento antibiótico con aminopenicilinas, trimetoprim-sulfametoxazol ni cefalosporinas de primera a cuarta generaciones por su elevada resistencia. La presencia de malformación urinaria se asocia a infección por bacterias diferentes a Escherichia coli.
Describing the Oral Health of Warfarin Users. A Short Report
Authors: Moreno Drada Johana Alejandra , Silva da Cruz Alex Junio , de Miranda Cota Luis Otávio , Parreiras Martins Maria Auxiliadora , Almeida Pordeus Isabela , Nogueira Guimarães de Abreu Mauro Henrique
Published: June 2023

Aim: To describe the burden of oral diseases and of self-reported periodontal disease of patients under Oral Anticoagulation Therapy (OAT) with warfarin.Methods: A cross-sectional study was conducted. Validated questionnaires assessed self-re-ported periodontal disease and demographic variables. After calibration (Kappa > 0.80), an examiner evaluated dental caries and the need for dental prostheses. Statistical analysis involved proportions and measures of central tendency. Results: The sample consisted of 158 individuals, with a mean age of 58.8 years (SD = 12.1), of which 62.7% of the participants were women. The average DMFT (Decayed, Mis-sing, and Filled Teeth) index was 22.9 (SD = 7.6), with the missing component being the highest (Mean = 16.23). The use of maxillary prosthesis (53.2%) was higher than mandibu-lar (32.3%). The need for mandibular prosthesis reached 66.5%. The percentage of partici-pants that referred gum disease, tooth migration, and tooth mobility was 29.6%, 37.4%, and 30.4%, respectively.Conclusions: The burden of oral diseases among individuals undergoing OAT is worrisome.
Hubungan antara Psychological Well-being dengan Kematangan Karier pada Remaja Santri di Pondok Pesantren Darut Taqwa Semarang
Authors: Asyrofah Hani Laeli , Kustanti Erin Ratna
Published: June 2023

Abstrak Penelitian ini bertujuan untuk mengetahui hubungan antara psychological well-being dengan kematangan karier pada remaja santri di Pondok Pesantren Darut Taqwa Semarang. Psychological well-being merupakan kondisi individu yang mampu berfungsi secara positif dan optimal yang memiliki ciri yaitu penerimaan diri, otonomi, hubungan positif dengan orang lain, menguasai lingkungan, memiliki tujuan hidup dan pengembangan diri. Sedangkan kematangan karier merupakan kemampuan individu dalam melaksanakan tugas-tugas perkembangan karier sesuai dengan tahap perkembangan tertentu untuk mencapai tujuan yang diinginkan. Populasi dalam penelitian ini yaitu remaja santri yang duduk dibangku MA/SMK sebanyak 107 subjek dengan sampel penelitian 75 subjek. Metode pengambilan sampel yang digunakan yaitu proporsionate sampling Pengumpulan data dilakukan dengan menggunakan Skala Psychological Well-being (22 aitem, α= 0.924) dan Skala Kematangan Karier (37 aitem, α= 0.935). Hasil penelitian menunjukkan terdapat hubungan positif yang signifikan antara psychological well-being dengan kematangan karier pada remaja santri. Analisis statistik menggunakan Analisis Regresi Sederhana yang menunjukkan koefisien korelasi sebesar 0.662 dengan signifikansi 0.000 (p<0.05). Psychological well-being memberikan sumbangan efektif sebesar 43,9% terhadap kematangan karier remaja santri.Kata kunci: kematangan karier, psychological well-being, remaja santri
Hubungan Antara Konformitas Teman Sebaya dengan Bullying Terhadap Guru
Authors: Putri Detania Hananti , Kustanti Erin Ratna
Published: June 2023

Siswa Sekolah Menengan Atas (SMA) adalah individu yang berada pada tahap perkembangan remaja. Masa remaja merupakan fase pencarian jati diri sehingga remaja banyak melakukan interaksi dengan lingkungan sosialnya, salah satunya adalah sekolah. Di sekolah, siswa berinteraksi dengan teman-temannya sehingga muncul perilaku konformitas. Konformitas yang negatif dapat memicu siswa untuk melakukan bullying. Saat ini bullying tidak hanya terjadi kepada siswa tetapi bullying juga terjadi pada guru. Penelitian ini bertujuan untuk mengetahui hubungan antara konformitas teman sebaya dengan bullying terhadap guru. Populasi pada penelitian ini merupakan siswa kelas XI di SMA Pusaka 1 Jakarta sebanyak 181 siswa. Sampel pada penelitian ini berjumlah 125 siswa yang diperoleh dengan teknik convenience sampling. Alat ukur yang digunakan menggunakan Skala Konformitas (21 aitem, α = 0,848) dan Skala Bullying (30 aitem α = 0,887). Analisis regresi sederhana menunjukkan adanya hubungan positif dan signifikan antara konformitas teman sebaya dengan bullying terhadap guru. Hasil analisis regresi sederhana menunjukkan nilai koefisien korelasi sebesar rxy = 0,303 dengan p = 0,000 (p<0,05). Konformitas teman sebaya memberikan sumbangan efektif sebesar 14,6% terhadap variabel bullying terhadap guru sementara sebanyak 85,4% dipengaruhi oleh faktor lain.
“Anakku Sumber Kekuatanku”: Interpretative Phenomenological Analysis tentang Pengalaman Unmarried Mother
Authors: Anindita Salsharosa Nabila
Published: June 2023

Menjadi hal yang tidak biasa apabila seorang wanita yang mengalami kehamilan pranikah tetap mempertahankan kehamilannya dan memutuskan untuk tidak menikah, terdapat pengalaman dan tantangan yang beragam yang menarik untuk dipahami. Tujuan penelitian ini adalah untuk memahami pengalaman ibu yang memiliki anak namun tidak menikah (unmarried mother). Penelitian ini melibatkan tiga partisipan menggunakan teknik purposive dengan kriteria yaitu unmarried mother, ditinggalkan pasangan, usia anak di bawah lima tahun, dan bersedia menjadi partisipan penelitian dengan mendatangani informed consent. Pengumpulan data dilakukan dengan in depth interview. Data dianalisis dengan Interpretative Phenomenological Analysis (IPA) diperoleh dua tema induk, yaitu: (1) latar belakang unmarried mother; (2) dinamika kehidupan unmarried mother; dan satu tema khusus untuk partisipan Y, yaitu (3) persoalan keluarga sebagai pendorong seks pranikah. Hasil penelitian menunjukkan bahwa latar belakang partisipan menjadi unmarried mother adalah karena adanya hambatan untuk menikah, dukungan sosial dalam merawat anak, kepercayaan pada janji pertanggungjawaban, serta kemantapan menjalani keputusan. Permasalahan yang dialami unmarried mother adalah konflik pada masa kehamilan, reaksi negatif orang sekitar, kesulitan menjalankan peran ganda sebagai orang tua dan memenuhi harapan personal, permasalahan psikologis, serta kekhawatiran menjalin relasi dengan lawan jenis. Partisipan menunjukkan sikap positif dalam memaknai kehadiran anak, penerimaan diri terhadap statusnya, dan pasangan hidup.
Pengalaman Bekerja Sebagai Caregiver di Wisma Tuna Ganda pada Ibu dengan Anak Balita
Authors: Utami Aliffia Dinda , Rahmandani Amalia
Published: June 2023

Anak tunaganda adalah anak yang menderita dua atau lebih ketunaan atau kecacatan dalam segi fisik, mental, emosi, dan sosial yang menyebabkan mereka memiliki ketidakmampuan dalam melayani kebutuhan sehari-hari. Seorang caregiver memiliki tugas sehari-hari yaitu memberikan dukungan dan bantuan dalam merawat anak tunaganda. Masalah tingkah laku dan keterbatasan yang dimiliki anak tunaganda seringkali memunculkan rintangan yang dirasakan oleh caregiver. Bekerja sebagai caregiver dan di sisi lain merupakan seorang ibu dengan anak balita, memunculkan adanya dua tuntutan peran, yaitu peran dalam pekerjaan dan dalam keluarga. Tujuan dari penelitian ini adalah untuk memahami pengalaman bekerja sebagai caregiver di Wisma Tuna Ganda pada ibu dengan anak balita. Partisipan berjumlah tiga orang yang dipilih melalui teknik purposive sampling. Metode pengumpulan data dilakukan dengan wawancara mendalam (in-depth interview). Kemudian data dianalisis dengan pendekatan Interpretative Phenomenological Analysis (IPA). Penelitian ini menghasilkan lima tema induk, yaitu (1) proses pengambilan keputusan bekerja sebagai caregiver di Wisma Tuna Ganda, (2) menjalani konsekuensi atas pekerjaan, (3) penyesuaian peran sebagai caregiver tunaganda, (4) penyesuaian peran sebagai ibu dari anak balita, (5) faktor penguat dalam mempertahankan bekerja. Penelitian ini juga menghasilkan satu tema khusus yang hanya muncul pada partisipan T, yaitu rasa bersalah terhadap anak asuh.
HUBUNGAN ANTARA KETERLIBATAN SISWA DENGAN KENAKALAN REMAJA PADA SISWA KELAS XI DI SMA TARUNA NUSANTARA
Authors: Saraswati Monica Nabila
Published: June 2023

Penelitian ini dilaksanakan dengan tujuan mengetahui hubungan antara keterlibatan siswa dengan kenakalan remaja pada siswa kelas XI di SMA Taruna Nusantara. Kenakalan remaja merupakan menyimpang dari norma-norma sosial di lingkungan tempat remaja itu tinggal. Keterlibatan siswa merupakan keterlibatan siswa sebagai aktivitas sekolah, yaitu aktivitas akademik maupun non-akademik yang melibatkan keterlibatan kognitif, emosi, dan perilaku. Partisipan dalam penelitian ini adalah 169 siswa kelas XI SMA Taruna Nusantara Teknik sampling yang digunakan dalam penelitian ini adalah convenience sampling. Alat ukur yang digunakan adalah skala kenakalan remaja (20 aitem, α= 0,879) dan skala keterlibatan siswa (26 aitem, α=0,894). Analisis data menggunakan analisis statistik non parametrik Spearman’s Rhomenunjukan adanya hubungan negatif yang signifikan antara keterlibatan siswa dengan kenakalan remaja pada siswa kelas XI di SMA Taruna Nusantara. (rxy = -0,789; p < 0,001). Semakin tinggi keterlibatan siswa siswa SMA Taruna Nusantara, maka semakin rendah kenakalan remaja. Sebaliknya, semakin rendah keterlibatan siswa siswa SMA Taruna Nusantara, maka semakin tinggi kenakalan remaja.
MENAKAR PEMAAFAN PADA PENYINTAS CYBERBULLYING
Authors: Setyawan Imam
Published: June 2023

The purpose of this study is to see an overview of cyberbullying survivors' forgiveness in post-pandemic life. This research uses a quantitative descriptive approach. The research subjects were obtained through a purposive sampling technique, with characteristics, students who are cyberbullying survivors, with an age range of 18-21 years. Screening is carried out with a cyberbullying questionnaire containing questions related to self-identity, types of cyberbullying (based on Willard's theory namely, flaming, harassment, denigration, impersonation, outing & trickery, exclusion, and cyberstalking), repeated experiences of cyberbullying, and perpetrators of cyberbullying, to ensure that the subject is truly are truly survivors of one or more types of cyberbullying. The research subjects were 109 students who were obtained from the screening results and statements of willingness. Data collection uses a scale of forgiveness (25 items, α =   .931). Data analysis was performed using the Statistical Packages for Social Sciences (SPSS) version 26.0 program. The results showed that the subject's forgiveness was in the medium category, with a total of 62 people (57%), and the empirical mean was 58.16, within the medium category range (50 – 75). These results indicate that the forgiveness of cyberbullying survivors is not optimal, there are still 32 people (29%), in the low category. This condition occurs because most of the subjects are dealing with more than one type of cyberbullying, as well as the anonymity factor of the perpetrators of cyberbullying, most of whom come from strangers. No significant differences were found between male and female survivors' forgiveness.
Invasive and noninvasive markers of human skeletal muscle mitochondrial function
Authors: Mancilla Rodrigo , Pava‐Mejia Diego , van Polanen Nynke , de Wit Vera , Bergman Maaike , Grevendonk Lotte , Jorgensen Johanna , Kornips Esther , Hoeks Joris , Hesselink Matthijs K. C. , Schrauwen‐Hinderling Vera B.
Published: June 2023

Mitochondria are organelles that fuel cellular energy requirements by ATP formation via aerobic metabolism. Given the wide variety of methods to assess skeletal muscle mitochondrial capacity, we tested how well different invasive and noninvasive markers of skeletal muscle mitochondrial capacity reflect mitochondrial respiration in permeabilized muscle fibers. Nineteen young men (mean age: 24 ± 4 years) were recruited, and a muscle biopsy was collected to determine mitochondrial respiration from permeabilized muscle fibers and to quantify markers of mitochondrial capacity, content such as citrate synthase (CS) activity, mitochondrial DNA copy number, TOMM20, VDAC, and protein content for complex I–V of the oxidative phosphorylation (OXPHOS) system. Additionally, all participants underwent noninvasive assessments of mitochondrial capacity: PCr recovery postexercise (by 31P‐MRS), maximal aerobic capacity, and gross exercise efficiency by cycling exercise. From the invasive markers, Complex V protein content and CS activity showed the strongest concordance (Rc = 0.50 to 0.72) with ADP‐stimulated coupled mitochondrial respiration, fueled by various substrates. Complex V protein content showed the strongest concordance (Rc = 0.72) with maximally uncoupled mitochondrial respiration. From the noninvasive markers, gross exercise efficiency, VO2max, and PCr recovery exhibited concordance values between 0.50 and 0.77 with ADP‐stimulated coupled mitochondrial respiration. Gross exercise efficiency showed the strongest concordance with maximally uncoupled mitochondrial respiration (Rc = 0.67). From the invasive markers, Complex V protein content and CS activity are surrogates that best reflect skeletal muscle mitochondrial respiratory capacity. From the noninvasive markers, exercise efficiency and PCr recovery postexercise most closely reflect skeletal muscle mitochondrial respiratory capacity.
A Study of Russian Artifacts in the Collection of Imperial Palace in the Qing Dynasty
Authors: Duo Limei
Published: June 2023

This article systematically examines the Russian cultural relics in the collection of the Qing imperial palace and analyzes the remnants of interactions between the Qing court and the Russian court during the reigns of Peter the Great, Nicholas I, and Nicholas II. Russian cultural relics witnessed significant historical events such as the establishment of diplomatic relations between China and Russia, exchange of envoys, and the signing of a series of treaties. They carried the mission of promoting the national cultures and advantageous industries of both countries at that time. In addition, these cultural relics have high aesthetic value and contain reliable and rich historical information.
Genetic analysis of sunflower fatty acids under optimum and water stressed conditions
Authors: Ghaffari Mehdi , Shariati Farnaz
Published: June 2023

In order to study the genetic control of sunflower fatty acids under optimum and water limited conditions a set of 12 sunflower hybrids were evaluated as randomized complete block design with three replications in two separate experiments during two years (2019 and 2020) in Karaj, Iran. The hybrids were obtained by crossing of four male sterile lines and three restorer lines as testers. Water limitation was imposed by water withholding during reproductive stage. Palmitic acid content was governed by both additive and non-additive effects and linoleic acid content by non-additive gene action under optimum and water limited conditions. Stearic acid content was controlled by both additive and non-additive effects in optimum but by additive effects under water limited condition. Oleic acid content was governed by non-additive factors in optimum, while by both additive and non-additive effects in water limited condition. Oil content and leaf temperature were inherited by additive and seed yield by additive and non-additive effects in both conditions. Relative water content and chlorophyll content were controlled by both additive and non-additive effects under optimum but by non-additive effects in water limited condition. According to these results hybrid breeding is suggested for improvement of main sunflower fatty acids under optimum and water limited condition except that selection-based methods for improvement of stearic acid content.
Breast cancer status, grading system, etiology, and challenges in Asia: an updated review
Authors: Tan Xiao Jian , Cheor Wai Loon , Cheng Ee Meng , Ab Rahman Khairul Shakir , Wan Muhamad Wan Zuki Azman , Leow Wai Zhe
Published: June 2023

The number of breast cancer incidences reported worldwide has increased tremendously over the years. Scoping down to Asia, in 2020, the reported incidences of breast cancer are appalling, comprising 1,026,171 cases, occupying up to 45.4% of cases across the globe. Breast cancer is a non-communicable disease, that emerges in variegated forms, self-subsistent, and the etiology is observed to be multifactorial, dependent on the individual reproductive pattern, hormonal factors, diet, physical activity, lifestyle, and exposure to certain advent procedures. Given this complexity, breast cancer is expected to undergo a persistent increment in the number of incidences in near future, exacerbating the public health quality, regardless of race, ethnicity, geographical subgroups, and socioeconomic. In this review article, the authors examine breast cancer in multiple facets, comprising the updated statistics on breast cancer, typically in Asia; etiology of breast cancer; diagnosis of breast cancer; grading system; and challenges in breast cancer from the country’s income perspective. Realizing the ever-increasing demand for quality treatment, here, the article also contemplates common therapies in breast cancer, such as breast-conserving therapy, mastectomy, postmastectomy radiation therapy, neoadjuvant chemotherapy, axillary surgery, chemotherapy, adjuvant medical therapies, biological and targeted therapies, and endocrine therapy. This review article intended to provide a brief yet broad panoramic view of breast cancer, to readers, ranging from newcomers, existing researchers, and relevant stakeholders in the topic of interest.
The inhibitory effects of lobaplatin, or in combination with gemcitabine on triple-negative breast cancer cells in vitro and in vivo
Authors: Jiang Chengyan , Zhang Ye , Xu Xiaoyu , Su Shanshan , Pan Huafeng , Jiang Aiqin
Published: June 2023

Objectives

To study the therapeutic effects of lobaplatin in combination with conventional chemotherapy drugs on triple-negative breast cancer (TNBC) cells.

Methods

We used the CCK-8 assay, flow cytometry, western blotting, and immunofluorescence staining methods to detect the effects of lobaplatin or in combination with gemcitabine on the survival, apoptosis, and cell cycle progression of TNBC cells. A cell-derived xenograft mouse model was used to verify the antitumor effects of lobaplatin alone or in combination with gemcitabine.

Results

Lobaplatin significantly inhibited MDA-MB-468 cell growth in vitro, either alone or in combination with gemcitabine. Lobaplatin arrested the cell cycle at the S phase, induced nuclear cell damage, and promoted apoptosis. Also, the percentage of apoptotic cells was greatly increased when lobaplatin was combined with gemcitabine. Cleaved Caspase-3 and Poly (ADP-Ribose) Polymerase-1 (PARP-1) fragments indicated that lobaplatin promoted apoptosis through the classical pathway. Lobaplatin effectively inhibited the growth of tumors in vivo. Compared with the vehicle group (567.6 ± 126.2 mm3), the tumor volume of the lobaplatin group (302.7 ± 131.6 mm3) was significantly reduced (p<0.01). The combination of lobaplatin and gemcitabine (207.7 ± 83.94 mm3) was a little better than lobaplatin alone in the inhibition of the transplanted tumor (p>0.05).

Conclusions

Lobaplatin alone or in combination with gemcitabine had significant inhibitory effects on MDA-MB-468 cells in vitro. Lobaplatin also significantly inhibited the growth of nude mice xenografts. The synergistic effect between lobaplatin and gemcitabine in vivo was minimal, perhaps due to the low dose of gemcitabine used.
Identification of cancer stem cells derived from U118MG and the involvement of LncRNA-DC and STAT3 in promoting their malignant transformation
Authors: Liu Qingxi , Lv Lihui , Leung Terry , Li Hui , Xiao Hairong , Lu Wange , Ma Wenjian
Published: June 2023

Objectives

Cancer stem cells (CSCs) are a subpopulation of cancer cells that share similarities with somatic stem cells. CSCs are believed to play a key role in carcinogenesis, metastasis, cancer relapse, and drug resistance. Despite their significant impacts, the specific biological markers for the identification of CSCs and their differentiation/transformation mechanisms have not yet been fully characterized.

Methods

Utilizing stem cell markers, the ability to differentiate in multiple directions, and resistance to radiotherapy and chemotherapy, CSCs were identified. To assess the variations in gene expression, gene alterations, protein expression, and cell proliferation between CSCs and U118MG glioma cells, second generation sequencing, Real-Time PCR, Western Blotting, and CCK-8 were employed.

Results

In this study, we identified a subset of CSCs in human U118MG glioma cells that expressed the stem cell biomarkers CD133+, OCT4+, and CD44+. These cells exhibited stem cell-like characteristics such as multilineage differentiation and resistance to chemical and radiation stresses. Notably, they can form neurons with electrical signals and sodium currents. Further study also revealed that the malignant growth of this CSC subset was controlled by long noncoding RNA (Lnc-DC) through the STAT3 pathway.

Conclusions

As a potential therapeutic approach, inhibiting Lnc-DC may be beneficial in hindering carcinogenesis and drug resistance, as it selectively targets the growth of CSCs.
The role of acetylation of histone H3 and H4 in oral squamous cell carcinoma
Authors: Li Lian , Tang Donge , Dai Yong
Published: June 2023

Oral squamous cell carcinoma (OSCC), which commonly develops in the tongue, buccal mucosa, and epithelium of the oral cavity, is the result of an accumulation of genetic and epigenetic alterations. In OSCC, other epigenetic alterations, such as histone modification were present. Histone modification can predict the prognosis of various cancers. Actually, the regulation and remodeling of chromatin structure caused by histone acetylation was crucial for the growth of tumors. Histone acetylation has received extensive research in OSCC, particularly histone H3 and H4. Additionally, the bulk of OSCC treatment plans focused on controlling the degree of histone acetylation. The acetylation sites of histone H3 and H4 that evolved in OSCC and the effects of these modifications on histone are therefore summarized below. Furthermore, the treatment of OSCC was implemented from the realization of normalizing histone acetylation levels in OSCC, and we summarized target drugs in the resumption of OSCC acetylation level. This review could help with understanding and treating OSCC.
Spiritual Care-Kompetenz in der Ausbildung – Skizze einer analytisch-konzeptionellen und empirisch-anwendungsbezogenen Untersuchung
Authors: Magin Susanne
Published: June 2023

Einleitung: Die Bereitstellung von Spiritual Care in der klinischen Praxis ist durch einen von den Gesundheitsfachpersonen wahrgenommenen Mangel an Spiritual Care-Kompetenz eingeschränkt.

Methode: Spiritual Care-Kompetenz wird im Rahmen der Ausbildung von Gesundheitsfachpersonen mithilfe zweier Untersuchungen beleuchtet. In einer analytisch-konzeptionellen Untersuchung erfolgt eine Begriffsklärung von Spiritual Care-Kompetenz, in einer empirisch-anwendungsbezogenen Untersuchung werden zwei Studien zur Spiritual Care-Kompetenz in der Ausbildung ausgewertet (Magin 2022c).

Ergebnisse: In der ersten Untersuchung wurden Bedeutungsdimensionen herausgearbeitet, die die Spiritual Care-Kompetenz charakterisieren. In der zweiten Untersuchung zeigte zum einen eine Analyse von Interviews, dass die Teilnahme an einem Online-Spiritual Care-Seminar zu Veränderungen in der Spiritual Care-Kompetenz führt. Zum anderen zeigte eine Fragebogenanalyse, dass Spiritual Care-Kompetenz ein veränderbares Konstrukt ist und die Teilnahme am Online-Spiritual Care-Seminar einen signifikanten Einfluss auf die wahrgenommene Spiritual Care-Kompetenz hat. In Zusammenführung beider Untersuchungen konnte das Gesamtverständnis von Spiritual Care-Kompetenz präzisiert werden: Spiritual Care-Kompetenz ist Relations- und Grenzsituationskompetenz und kann durch ein gezieltes Lehrangebot gefördert werden.

Diskussion: Die Ergebnisse sind sowohl für das Verständnis von Spiritual Care-Kompetenz als auch für die Aus- und Weiterbildung in Spiritual Care relevant. Um die Spiritual Care-Kompetenz unter Gesundheitsfachpersonen zu verbessern, gilt es, Spiritual Care-informierte Lehre auszubauen.
Machine learning approach for impedance locus uncertainties
Authors: Bifano Luca , Michel Markus , Weidl Max , Fischerauer Alice , Fischerauer Gerhard
Published: June 2023

This work deals with the determination of the uncertainty of measurement data, determined by electrical impedance spectroscopy. Four different types of sand were measured impedimetrically in a measuring cell designed as a plate capacitor in a frequency range from 20 Hz to 1 MHz. The measuring cell was filled ten times with each sand and 20 impedance spectra were recorded for each filling. The uncertainty at each frequency was determined from the measurement data. It was found that the measurement data variance with a given measuring-cell filling was negligibly small. However, it increased by a factor of up to 100 when the measuring cell was repeatedly emptied and re-filled with the same material. We propose a way to estimate a continuous approximation of the uncertainty band of the impedance locus in the complex plane from the discrete uncertainties at each frequency. It uses a Support Vector Machine (SVM) to generate a regression curve using the discrete uncertainties. The result of the regression was used to estimate the uncertainties of an average impedance locus. The said machine learning tool can handle large amounts of data, classes, and influencing variables. In this manner, it can help to identify cause-effect relationships. Furthermore, at the end of this work a possibility to estimate a continuous uncertainty band along the impedance locus curve via SVM regression is shown. This is an extension to the common methodology in literature, where the uncertainty is only determined at selected individual points of the impedance spectrum.
Increased endoplasmic reticulum stress might be related to brain damage in hepatic ischemia-reperfusion injury
Authors: Karademir Mustafa , Doğan Halef O. , Sahin İnan Zeynep Deniz , Doğan Kübra , Kablan Demet
Published: June 2023

Objectives

Our study aimed to investigate the role of endoplasmic reticulum stress (ER) in brain damage following hepatic ischemia-reperfusion (HIR) injury. Specifically, we characterized the expression of markers of ER stress and histopathologic changes in the brain following HIR.

Methods

Twelve adults female Wistar rats were divided into two experimental groups equally. Group 1 was designed as the control group, and Group 2 was designed as the HIR group. Blood, liver, and brain tissue samples were collected during the sacrifice. The quantitative ELISA kits were used to detect glucose-regulated protein 78 (GRP-78), activating transcription factor 4 (ATF-4), eukaryotic initiation factor 2 alpha (EIF2-A), caspase-3, caspase-9, and CCAAT/enhancer-binding protein (CEBP) in plasma. Histopathological examination was performed for liver and brain tissues.

Results

Higher levels of GRP-78 (p=0.006), ATF4 (p=0.001), and EIF2-Α (p=0.007) were detected in group 2. More damage was detected in liver and brain samples in the histopathological examination of group 2 than in group 1.

Conclusions

Our results demonstrate that ER stress is involved in developing brain damage following hepatic ischemia-reperfusion injury, as evidenced by increased expression of markers of ER stress and neuronal injury.
Evaluación de la dieta y su emisión de CO2 en población mexicana durante el confinamiento en casa por la covid-19
Authors: Kala Saldaña Axel Roberto , Espinosa Ayala Enrique , Baeza Jiménez Ramiro , Márquez Molina Ofelia
Published: June 2023

La dieta humana influye en las cadenas de producción de alimentos, las cuales emiten alrededor del 30% de los gases de efecto invernadero (GEI) a nivel mundial. El objetivo es identificar los cambios en la dieta y la producción de CO2 en adultos mexicanos antes, durante y después del confinamiento por covid-19. La frecuencia de consumo de alimentos se determinó mediante un cuestionario electrónico completado por 1114 participantes, a partir del cual se calcularon las emisiones de CO2 asociadas. Se identificaron tres grupos de alimentos (de alto, medio y bajo impacto ambiental) en función de su CO2 incorporado. Las dietas más variadas consumidas después del confinamiento se caracterizaron por una disminución significativa de la ingesta de productos animales y un aumento de frutas (0.5), verduras (0.4), cereales (1.2) y leguminosas (0.3). El confinamiento covid-19 se identifica como un factor para la modificación de la dieta y sus emisiones de CO2 asociadas.
La percepción de la crianza y el afrontamiento del conflicto como predictores de las autolesiones no suicidas en adolescentes
Authors: Salazar Suarez Olivia , Van Barneveld Johannes Oudhof , Robles Estrada Ericka , Rodríguez Aguilar Brenda
Published: June 2023

El propósito de este estudio fue determinar si la percepción de la crianza y el estilo de afrontamiento del conflicto predicen las autolesiones no suicidas en adolescentes. Se realizó un muestreo no probabilístico en 495 participantes (38.4% hombres y 61.6% mujeres) de 11 a 18 años, en el Estado de México. El análisis estadístico arrojó una presencia de autolesiones de 23.2% en adolescentes, donde resalta la media más alta para mujeres que para hombres en las autolesiones por encima de la piel (1.57 vs. 1.36) y debajo de la piel (1.40 vs. 1.20). Se obtuvieron correlaciones estadísticamente significativas de las autolesiones con la percepción de la crianza y con los estilos de afrontamiento productivo, relacionado con otros e improductivo. Se concluye que los estilos de afrontamiento y la percepción de la crianza inciden en la frecuencia de autolesión, por lo que para la comprensión de las autolesiones en adolescentes es necesario considerar diversos factores individuales y contextuales.
Formação profissional e mundo do trabalho: reflexões a partir de um curso técnico em enfermagem
Authors: Ferraz Carmo Rose , Nathale Soares Amanda , Carneiro Luiz Brant , De Lima Ferreira Vargas Michely , Dias Bevilacqua Paula
Published: June 2023

A articulação entre formação e mundo do trabalho norteou o desenvolvimento deste estudo cujo objetivo foi analisar aspectos educativos de um curso técnico em enfermagem e as implicações no trabalho de seus egressos. Foram realizadas entrevistas semiestruturadas com egressos, suas chefias imediatas, a coordenadora do curso e pedagogas que atuavam no curso. Os depoimentos foram tratados pela Análise de Conteúdo a partir das categorias processo educativo e trabalho. Formato, conteúdo e docentes foram bem avaliados pelos egressos. Foram destacadas a relevância da integração entre momentos de concentração e dispersão do curso para a construção gradual do conhecimento e as dificuldades de agregar, ao cotidiano de trabalho, conhecimentos, habilidades e vivências construídas durante o processo educativo. Entendemos que a Educação Permanente em Saúde constitui um caminho para superar essas dificuldades.
Formação de professores: da função atribuída à teoria ao recuo da crítica
Authors: Fernandes Anoel
Published: June 2023

Este estudo teve como objetivo apreender a forma com que um grupo de professoras atuantes no ciclo I da rede pública estadual paulista lida com os conhecimentos teóricos. Buscou-se responder a seguinte questão: qual a função atribuída aos conhecimentos teóricos por um grupo de professoras atuantes na rede pública estadual paulista? Como procedimento de pesquisa, aplicou-se um questionário para 37 professoras. Como referência de análise, utilizou-se a relação entre formação e pragmatismo tal como desenvolvido pela teoria crítica da sociedade. Os dados permitem a especulação de que, quanto maior for à aversão à teoria, menor será a capacidade de o indivíduo desenvolver a crítica da realidade.
Biopolítica e Medicalização: articulações entre o saber médico e o saber pedagógico
Authors: Da Rosa Camila Francisca , Kopp Carlos Augusto Ferreira
Published: June 2023

A educação é entendida como espaço privilegiado de regulação e captura de sujeitos dada a sua abrangência em atingir a globalidade, ou seja, uma importante estratégia para o governamento biopolítico – o governo sobre a vida do corpo-espécie da população. O artigo objetiva analisar a relação entre os saberes pedagógico e médico na constituição do sujeito-aluno, visto que cada vez mais a medicalização dos jovens sobre a égide discursiva do melhoramento da aprendizagem tem gerado efeitos constituidores dentro do espaço escolar, na prática docente e na constituição dos sujeitos inseridos nesse espaço. Como corpus discursivo deste trabalho, foram analisados o programa Saúde na Escola e reportagens da Revista Nova Escola, para entendermos a produção de sujeitos constituídos na relação entre saber médico e saber pedagógico.
Problematização e contraconduta na composição de um currículo do devir para o enfrentamento da distorção idade-série
Authors: Traversini Clarice Salete , Reis Júlia Milani , Sperrhake Renata
Published: June 2023

Este artigo objetiva analisar os efeitos do currículo e da avaliação do Projeto de enfrentamento da distorção idade-série nos Anos Finais do Ensino Fundamental, no sul do Brasil, em tempos de Base Nacional Comum Curricular (BNCC). Utilizamos as noções foucaultianas de problematização e de contraconduta e produzimos a empiria por meio de um grupo focal com professores de uma das escolas que iniciou o Projeto, em 2012. Como resultados, percebemos que, quando os docentes se afastam da "aplicação" da BNCC, construindo seus próprios currículos, e optam por avaliações que consideram o aluno na totalidade de seus aprendizados, operam com a problematização e exercem ações de contraconduta. Estas operações possibilitam compor um currículo do devir, deslocando os estudantes da posição de "distorcidos pela idade-série", isto é, de excluídos na escola, para construir posições de sujeitos-alunos aprendentes que seguem o fluxo escolar.
A Língua Brasileira de Sinais no cenário das licenciaturas
Authors: Grãff Patrícia
Published: June 2023

A presente pesquisa tomou a Língua Brasileira de Sinais (Libras) como objeto de estudo e pretendeu identificar se e como ela vem sendo ofertada na forma de componente curricular nas instituições de Ensino Superior. Inspirada nos Estudos Foucaultianos e usando o discurso como ferramenta metodológica, pautou-se em uma busca nas páginas eletrônicas de instituições de Ensino Superior à procura de matrizes curriculares e ementas. Os dados da pesquisa permitiram concluir que todas as instituições de Ensino Superior pesquisadas ofertam a Libras como componente curricular obrigatório para as licenciaturas. Da análise das ementas depreende-se que se apresentam de forma heterogênea, concentrando-se nas discussões sobre os aspectos linguísticos da Libras; a história de sua constituição e as concepções de cultura e identidade surdas. Perifericamente, discutem a ênfase inclusiva para a educação de surdos; possibilitam práticas de conversação e apresentam o SignWriting.
Atualidade de Paulo Freire: há razões para retomar o seu legado e comemorar o seu centenário?
Authors: Ghiggi Gomercindo , Nörnberg Marta
Published: June 2023

Paulo Freire completa em 2021 o seu centenário. Neste mesmo ano, a Faculdade de Educação da UFPel comemora 45 anos de história. E tomando os tempos atuais como base para pensar a educação, a vida e o diálogo, em contraponto à morte e à intolerância, algo resta para celebrar? E por que Freire como fonte principal para o diálogo ante os desafios contemporâneos?
100 anos de Paulo Freire: diálogos com Antônio Gramsci sobre senso comum, imersão e intransitividade
Authors: Protásio Alexandre Reinaldo
Published: June 2023

O presente artigo tem por objetivo realizar uma aproximação teórica entre Paulo Freire e Antônio Gramsci, com foco nos conceitos de senso comum, imersão e intransitividade. E, dessa forma, estabelecer um conjunto de pontos de contato que ofereçam ao leitor instrumentos teóricos para analisar a sociedade capitalista e os processos de dominação/opressão. A questão central do artigo é: como dominam os dominadores? Freire e Gramsci, no entender do autor, oferecem, em conjunto, uma poderosa crítica negativa da sociedade capitalista e das diversas formas de opressão às quais os oprimidos estão submetidos. As formas de imersão das consciências em um determinado tipo de senso comum estabelecem um estado debilitante de intransitividade da consciência, transformando os oprimidos em seres duais, acríticos, aderentes ao opressor. Portanto, seres acomodados e adaptados, devidamente conformados ao funcionamento da sociedade capitalista. E, nesse sentido, a educação “bancária” desempenha um importante papel, contribuindo para a promoção e manutenção da dominação de classe. No centenário de Paulo Freire, o presente artigo também demonstra uma das principais características das reflexões freirianas e gramscianas: o diálogo crítico com diferentes tradições filosóficas, possibilitando a construção de uma densa contribuição teórica ao processo de libertação dos oprimidos(as).
Carta sobre Cartas Pedagógicas: homenagem a Paulo Freire no ano do centenário de seu nascimento
Authors: Freitas Ana Lúcia Souza de
Published: June 2023

O artigo, elaborado em forma de Carta Pedagógica, tem a intenção de apresentar, no conteúdo e na forma, contribuições para argumentar sobre o potencial teórico-metodológico intrínseco à expressão cunhada por Paulo Freire. Compreende-se que a expressão é convidativa à reinvenção do pensamento freireano e fecunda para vislumbrar possibilidades de articulação entre ações de ensino, pesquisa, extensão e gestão. Partindo deste entendimento, produzido na diversidade das experiências compartilhadas nas andarilhagens de uma educadora pesquisadora, no âmbito da formação com professores/as e gestores/as, apresenta-se uma sugestão de cinco apontamentos para esboçar a escrita de uma Carta Pedagógica. Para além de apresentar um passo a passo, a intenção é convidar ao diálogo sobre o Tetragrama da (trans)formação permanente enquanto matriz teórico-conceitual de referência para compreender e exercer a complexidade do processo deflagrado com a proposição das Cartas Pedagógicas como instrumento metodológico de formação.
ADIÇÕES À FLORA AMEAÇADA DE EXTINÇÃO DO PONTAL DA BARRA, PELOTAS, RS: ANNONA MARITIMA (ARATICUM-DA-PRAIA) E TERNSTROEMIA BRASILIENSIS (PINTA-MOÇA)
Authors: Salazar Enrique Araújo , Venzke Tiago Schuch Lemos , Maurício Giovanni Nachtigall
Published: June 2023

ADIÇÕES À FLORA AMEAÇADA DE EXTINÇÃO DO PONTAL DA BARRA, PELOTAS, RS: ANNONA MARITIMA (ARATICUM-DA-PRAIA) E TERNSTROEMIA BRASILIENSIS (PINTA-MOÇA)
PHYSICOCHEMICAL, MICROBIOLOGICAL AND SENSORY ANALYSES OF FUNCTIONAL DETOX JUICES FERMENTED WITH WATER KEFIR GRAINS
Authors: GÜLHAN Ayca
Published: June 2023

In this study, detox juice prepared from green fruit and vegetable juices was fermented with water kefir grains at 25 ℃ for 48 hours and stored at 4 ℃ for 6 days. The samples had pH values of 3.41-3.97, titratable acidity of 0.196-0.495 g/100 mL, and brix values of 8%-10.4%. The 0th day samples had less phenolic substance than the control (861.26±0.24 mg GAE/L) (P<0.05). DPPH (82.2±0.19%) and CUPRAC (1.18±0.05 mmol Trolox/g) were the highest on the 6th day of storage. At the end of fermentation, an increase in color values for L* and b* and a decrease in a* value were determined (P<0.05). The microorganism loads rose from the 2nd to the 6th day of storage. Green fruit and vegetable juices may be utilized to make water kefir, an innovative functional beverage for vegetarians and vegans who can not consume probiotic dairy products.
Hypoxia causes pancreatic β‐cell dysfunction and impairs insulin secretion by activating the transcriptional repressor BHLHE40
Authors: Tsuyama Tomonori , Sato Yoshifumi , Yoshizawa Tatsuya , Matsuoka Takaaki , Yamagata Kazuya
Published: June 2023

Hypoxia can occur in pancreatic β‐cells in type 2 diabetes. Although hypoxia exerts deleterious effects on β‐cell function, the associated mechanisms are largely unknown. Here, we show that the transcriptional repressor basic helix–loop–helix family member e40 (BHLHE40) is highly induced in hypoxic mouse and human β‐cells and suppresses insulin secretion. Conversely, BHLHE40 deficiency in hypoxic MIN6 cells or β‐cells of ob/ob mice reverses defects in insulin secretion. Mechanistically, BHLHE40 represses the expression of Mafa, encoding the transcription factor musculoaponeurotic fibrosarcoma oncogene family A (MAFA), by attenuating the binding of pancreas/duodenum homeobox protein 1 (PDX1) to its enhancer region. Impaired insulin secretion in hypoxic β‐cells was recovered by MAFA re‐expression. Collectively, our work identifies BHLHE40 as a key hypoxia‐induced transcriptional repressor in β‐cells that inhibit insulin secretion by suppressing MAFA expression.
Proyecciones Vintage: Mad Men y Cuéntame cómo pasó / Vintage Projections: Mad Men and Cuéntame cómo pasó
Authors: García Pousa Laura
Published: June 2023

Las series de televisión han puesto a prueba la capacitación del drama mediante la construcción de un discurso propio y diferenciado, que las convierte en uno de los referentes artísticos contemporáneos de mayor expansión. En este artículo acudimos a su estudio específico como nuevos artefactos culturales que trabajan con múltiples realidades y niveles narrativos creando ficciones capaces de aglutinar éxito comercial y nuevas parcelas audiovisuales que generan reflexiones sobre la representación de la memoria histórica. Aunque distantes en su concepción, desarrollo, producción y tratamiento, nos centramos en Mad Men (AMC: 2007-) y en Cuéntame cómo pasó (Grupo Ganga: 2001-) por su importante trabajo de contextualización dramática donde la cultura popular, la visión mediatizada y los mitos se convierten en constantes de sus narraciones. El estudio comparativo de dos nudos dramáticos como son el asesinato de John F. Kennedy en Mad Men y el atentado contra Carrero Blanco en Cuéntame cómo pasó nos permitirá iniciar y profundizar en las formas argumentales, discursivas y estéticas de ambas producciones dentro de su desarrollo en continuidad como obras de ficción de largo recorrido.Palabras clave: series de televisión, ficción, memoria, historia, representación, Mad Men, Cuéntame cómo pasó, cultura popular, identidad.AbstractTelevision series have challenged the drama by constructing a personal and differentiated discourse, turning it into one of the contemporary artistic genres experiencing the greatest expansion at the moment. In this article, we’ve undertaken the study of such series as new cultural artifacts that work with multiple realities and narrative levels, creating fictions that garner commercial success, and new audiovisual parcels that generate reflections on the representations of historical memory. Although distinct in their conception, development, production and material, we will focus on the series Mad Men (AMC: 2007-) and Cuéntame cómo pasó (Grupo Ganga: 2001-) for their important work in dramatic contextualization, where popular culture, a mediatised vision and myths are fixed elements of their narratives. The comparative study of two dramatic climaxes like the murder of John F. Kennedy in Mad Men and the terrorist attack on Carrero Blanco in Cuéntame cómo pasó will serve as our point of departure and allows us to study in greater depth the argumentative, discursive and aesthetic forms of both productions within their ongoing development as fictional works of long standing.Keywords: television series, fiction, memory, history, representation, Mad Men, Cuéntame cómo pasó, popular culture, identity.
Condenados de Manuel Mur Oti (1953): Lorca en Castilla / Condenados by Manuel Mur Oti (1953): Lorca in Castille
Authors: Zubiaur Gorozika Nekane
Published: June 2023

Condenados, tercer largometraje del cineasta gallego Manuel Mur Oti, es un apasionado drama rural que narra la historia de un sangriento triángulo amoroso. Pese a tratarse de la adaptación de una obra teatral de José Suárez Carreño, el análisis fílmico de la película, articulado en torno a la puesta en escena de las miradas de sus protagonistas, revela que en realidad el filme solo guarda relación argumental con l a obra original, centrada en el concepto calderoniano de la honra. Mur Oti depura todos los componentes sociales, religiosos y psicológico s del texto de Suárez Carreño para poner en escena un relato mítico, una cosmogonía temáticamente vinculada al resto de dramas rurales firmados por el autor, sobre el hombre y la mujer primigenios de naturaleza esencialmente fecunda. Un relato más estrechamente emparentado con el espíritu de la tragedia lorquiana que con el tradicional drama rural que le sirve de base en tanto que Aurelia, protagonista femenina de Condenados, se nos presenta como heredera directa de la Yerma de Lorca, dispuesta a sacrificar de manera irracional su propia naturaleza por mantener un matrimonio que el destino le ha otorgado, pese a que ello suponga la condena a la eterna esterilidad.Palabras clave: Condenados, Mur Oti, Suárez Carreño, Lorca, Yerma, drama rural.AbstractCondenados, Manuel Mur Oti’s third film, is a passionate rural drama which depicts a bloody love triangle. Although based upon a play by José Suárez Carreño, the analysis of the mise en scène reveals that, in fact, the film adaptation shares only the original plotline dealing with the traditional concept of honour. Mur Oti purges every social, religious or psychological element from Suárez Carreño´s text and stages, like in his other rural dramas, a mythical tale, a cosmogony about the primordial and essentially fertile male and female. The film is closer in spirit to Lorca’s tragedy than to the play it adapts since Aurelia , the protagonist of Condenados, is portrayed as Yerma´s reflect ion: a woman irrationally ready to sacrifice her own female essence in order to save the marriage she´s been given by fate, even if such a decision condemns her to eternal infertility.Keywords: Condenados, Mur Oti, Suárez Carreño, Lorca, Yerma, rural drama.