bluuebunny/crossref_metadata_2025 huggingface dataset:
The Two-Pronged Palestinian Response to Exclusion Within Israel
Authors: Rass Rida Abu
Published: July 2024

The Palestinian leadership within Israel has undergone a series of political–organizational transformations since 2015, oscillating between cohesive and fragmented mobilization. Why did the leadership fragment, despite both structural and electoral pressures to maintain unity? What explains the rapid nature of these transformations? Relying on 35 interviews with activists and politicians, I argue that declining political opportunities and mounting threats led the Palestinian leadership to pursue unity as a strategic choice in 2015. Crossing a threshold, however, the perception of further diminishing opportunities for change elicited divergent strategic responses between a group that I label “hegemonic-accommodationist,” spearheaded by Mansour Abbas’ United Arab List, and a group that I label “hegemonic-rejectionist,” representing the rest of the Palestinian political leadership. Overall, this study suggests that unity and disunity within ethnopolitical movements are linked to leaders’ perception of opportunity (and the lack thereof).
Pharmacovigilance and patient safety: The interplay of nursing, diagnosis, and medical records
Authors: AlQattan Khaled Mohammed , AlQahtani Mansour Ali , Almahboub Maha Saad , Alruwaili Enas Salem , Almermish Abdulaziz Hajjaj , AlGhanim Wael Ibrahim
Published: July 2024

Background _ Pharmacovigilance, as defined by the World Health Organization, involves the scientific and operational activities aimed at identifying, evaluating, comprehending, and mitigating the adverse effects or any issues associated with medicines or vaccines. It plays a crucial role in recognizing negative effects of medications that may escape detection during clinical trials. This scrutiny is particularly vital for older individuals, who are frequently excluded from clinical studies due to their comorbidities and polypharmacy, resulting in treatment regimens that extend beyond the duration of these trials. Aim of Work – The aim of this narrative review is to explore novel approaches in pharmacovigilance studies focused on medications for elderly individuals. It specifically highlights how advancements in digital health technologies, electronic health records, and real-world health data can enhance the detection and evaluation of adverse effects in this sensitive population. Methods – The review employs a narrative approach, synthesizing current literature on the utilization of digital health technologies and available health data in pharmacovigilance. It emphasizes recent developments in electronic health records and real-world data analytics, assessing how these tools can facilitate the monitoring of medication safety among older patients.
Evaluation of a reflective practice group for social care managers
Authors: Harris Natashia , Kurtz Arabella , Towey Marsha , Tahir Ameena
Published: July 2024

Registered Managers in care settings have complex and varied roles, including supporting the staff and those they serve in care homes and domiciliary services. A Department of Health white paper acknowledged that often registered managers do not receive adequate training and support to fulfil this vital role (Department of Health, 2012). In 2020 in response to the pressures of the covid pandemic the UK government set up 41 county-wide mental health hubs offering psychological support to health and social care staff. This hub offered co-produced bi-monthly training days for registered managers for a period of a year, of which a reflective practice group using the Heads and Hearts model was a key element (Kurtz, 2022; Kurtz, 2020). This model provides groups with structure and purpose in looking at the emotional impact of the work, and thinking through practice dilemmas, both in terms of client care and management of staff. Participants’ experiences of the group were explored using semi-structured interviews conducted by a trainee clinical psychologist and senior assistant psychologist in the service and was analysed using thematic analysis. Three superordinate themes were identified: Peer support and collaboration, reflexivity and thinking differently, and confidence in making changes. The frame of reflective practice, including the size and stability of the group, were identified as important factors in the participants’ experiences of the group. Suggestions for future research and practice are also discussed.
The role of Higher Education Institutions in training engineers for the era of circular economy: the Portuguese case
Authors: Vidal Raphaela , Marques Pedro Carmona , Vidal Filho Walter de Britto , Afzal Arisha
Published: July 2024

The transition from linear economy (LE) towards a circular economy (CE) is Europe Union´s (EU) concerned and involve lot of efforts and actions. Education for circular economy (ECE) is emergent. This paper aims to map Higher Education Institutions (HEIs) in Portugal, Bachelor’s and Master’s degree programs and Postgraduate courses in Industrial Engineering and Management (IEM) that address CE in their curricula with the aim of empowering students for the new era. A systematic search was performed to identify B.Sc./ M.Sc. in IEM of Portuguese Universities and Polytechnic Institutes, public and private, analyzing the content of their curricular units. As results, this study did not identify a strong interest about CE on the part of HEIs and their lecturers. Findings suggest that HEIs are not training future IEM engineers for the era of CE.  This study contributes to make an alert to HEIs and their lecturers to review their teaching process, stimulating to improve the quality of the IEM curricula. We suggest a deep reform of the professional curriculum system, enriching curricular. Future studies can approach skills and competences developed towards CE what facilitate a redesign of courses.
Removal of two cationic dyes by adsorption on F400 commercial activated carbon
Authors: Batana Fatima Zohra , Babaghayou Meriam Imane , Zoukel Abdelhalim , Karef Salah
Published: July 2024

In this investigation, we studied the removal of two cationic dyes, methyl green MG and malachite green Mc G, by a commercial adsorbent. This adsorbent is a F400 activated carbon with a specific surface area of 1203 m2. g-1, which is expected to be high compared with ordinary adsorbents. Adsorption tests were carried out on both dyes in batch mode. The results show that both kinetics are fast, with equilibrium reached after 20 minutes and 30 minutes respectively for Methyl Green and Malachite Green. The kinetics of both dyes are well adapted to pseudo-second order, and for the intraparticle diffusion model, two lines can be distinguished for each dye, proving the existence of two adsorption steps. The isotherm for this system reveals an L-type shape for both dyes, in line with the classification of Giles & al. so there is little competition for sorption sites between solvent and adsorbate. The adsorption isotherms for methyl green by PAC obeyed the Langmuir, Freundlich and Temkin models, while that for malachite green followed only the Langmuir isotherm, with a much higher maximum amount.
O papel crucial da aquisição de imagens estendida na tomografia computadorizada para a detecção de nefrolitíase em homens: uma análise de casos
Authors: Silva Anderson Matheus Pereira da , Bastos Luiz Augusto Gonçalves da Silva Dutra , Oliveira Victoria Hamaoka de , Saturnino Caroline Momente Martins , Branco Sarah Cecília Guimarães Castelo , Almeida Bruna Barbosa de , Fernandes Neto Rildo Cavalcanti , Medeiros Maria Udijaíra Fernandes de , Fagundes Julianna Pereira , Justo Marina Pinheiro Bezerra , Fagundes Maria Eduarda Phaelante Brito , Lima Keylla Raissa de Paula , Cordeiro Lígia Pinheiro
Published: July 2024

Este estudo analisa uma série de casos clínicos de pacientes do sexo masculino com dor abdominal inicial e suspeita de nefrolitíase, destacando a importância da inclusão da região genital na aquisição de imagens durante a tomografia computadorizada (TC). Observou-se a presença de cálculos em processo de expulsão na uretra prostática e membranosa, áreas de maior estreitamento na uretra masculina. A TC helicoidal, devido à sua alta sensibilidade e especificidade, é considerada o exame de imagem padrão-ouro para a avaliação e confirmação diagnóstica de nefrolitíase. Além disso, a TC permite a visualização detalhada da localização e do tamanho dos cálculos, essencial para o planejamento terapêutico. A análise evidenciou que a inclusão da região genital nas imagens tomográficas aumenta a precisão diagnóstica, contribuindo para a escolha de intervenções mais eficazes e a redução de complicações. Este estudo também abordou um caso de um paciente idoso com histórico de prostatectomia, destacando a utilidade da TC em diagnósticos complexos. A TC sem contraste oferece uma alternativa rápida e não invasiva, sendo especialmente útil em ambientes de urgência/emergência. Este trabalho reforça a necessidade de protocolos clínicos atualizados que incorporem a expansão do campo de visão na TC abdominal, abrangendo a região genital para diagnósticos mais completos e precisos. Os resultados obtidos são relevantes tanto para a prática clínica quanto para futuras pesquisas, sugerindo a importância de estudos adicionais com amostras maiores e mais diversificadas.
Audit Committee as A Moderating Variable: Factors Influencing Audit Quality in Financial Sector on the IDX
Authors: Andardini Siti Eka Resti , Erlina Erlina , Adnans Abdhy Aulia
Published: July 2024

This study aims to determine the effect of audit quality, namely audit tenure, audit rotation, and audit fees on audit quality in financial sector companies listed on the Indonesia Stock Exchange. In addition, this study also aims to determine whether the audit committee can be used as a moderating variable in the model. The type of data used in this research is secondary data. The technique of determining the sample is using purposive sampling. The samples obtained in this study were 17 manufacturing companies listed on the IDX from 2017 to 2021. The data analysis technique used was panel data regression analysis and interaction test (moderating) which was carried out with the help of EVIEWS version 10 software. The results in this study indicate that partial tenure audits have a positive effect on audit quality and are not significant. Audit rotation has a negative effect on audit quality and not significant. Audit fees have a negative effect on audit quality and not significant. The audit committee is unable to moderate audit tenure, audit rotation, audit fees on audit quality. The audit committee is unable to moderate audit tenure, audit rotation, audit fees on audit quality.
NURSES’ KNOWLEDGE AND ATTITUDES TOWARDS DIETARY MANAGEMENT OF PATIENTS WITH DIABETES MELLITUS
Authors: MUHAMMAD RG , SAFDAR N , SHAHEEN T
Published: July 2024

Proper dietary management is crucial for patients with diabetes mellitus, and nurses play a key role in educating and managing these patients. Understanding nurses' knowledge and attitudes towards dietary management can help improve patient care. Objective: To assess the knowledge and attitudes of nurses towards dietary management of patients with diabetes mellitus. Methods: A cross-sectional study was conducted in the Nursing Department of Lahore General Hospital, Multan, from June 2023 to June 2024. A total of 150 nurses from medical and surgical wards were selected through convenience sampling. Data were collected using a self-administered questionnaire, which was anonymous and took 15-20 minutes to complete. The questionnaire was divided into three sections: demographic, social, and professional information; a modified version of the 20-item Nutritional Management of Diabetes Knowledge Test; and a 14-item Nurses’ Attitudes about Nutritional Management of Diabetes Questionnaire. Descriptive statistics were used to summarize the data, and Pearson’s correlation analysis was employed to explore the relationship between knowledge and attitudes. Results: The mean knowledge score among the nurses was 11.20 ± 1.90, with scores ranging from 5 to 17. After standardization, 90 nurses (60%) exhibited moderate knowledge of nutritional management for diabetes. The mean attitude score was 59.71 ± 5.98, with 129 participants (86%) demonstrating a favorable attitude. Pearson’s correlation analysis showed no statistically significant association between knowledge and attitude (r= -0.070, p= 0.419). Conclusion: The study found that nurses generally had moderate knowledge and a favorable attitude toward the dietary management of diabetic patients. These findings suggest a need for targeted educational interventions to enhance nurses' knowledge in this area, potentially improving patient outcomes.
THE EFFECT OF MEDICINAL PLANTS AND THE GENTAMICIN AGAINST SELECTED BACTERIA : IN VITRO STUDY
Authors: Shakurfow Fathi Abdallah , Edalim Ali Salem Faraj , Elgutt Osama Milad , Abdalla Abdelkrem Mohamed Bashir , Zaet Abd urraouf
Published: July 2024

Antimicrobial-resistant bacteria are becoming more serious danger to worldwide public health. As a result, the efficacy of traditional antimicrobials is fast falling, posing a threat to healthcare providers’ capacity to treat common infection. Bacterial infective diseases are an important reason of sickness and death globally. Several medicine resistances in human pathogenic microorganisms had develop because of undiscriminating custom of commercial anti-microbial medicines.The main objective of the present study is, to evaluate the ability of the plants extract, to inhibit the growth of pathogenic bacteria with and without antibiotics and non-antibiotics drugs. Also, to enhance the activity of antibiotics or non-antibiotics drugs against selective pathogenic bacteria, to investigate antibacterial effects of thyme crude extract (Tm), ginger crud extract (Gi), garlic crud extract (Ga) and acacia crud extract (AC) against Escherichia coli ( E.coli) and Staphylococcus aureus (S.aureus) and to investigate the ability of increasing the potency of Gentamycin antibiotic against E. coli and S. aureus by mixed with thyme crude extract (Tm), ginger crud extract (Gi), garlic crud extract (Ga) and acacia crud extract  (AC). Material and methods, in this study used gentamicin mixed with for types of crud extracts garlic, ginger, acacia, and thyme against two types of bacteria E. coli and S. aureus. Used disc diffusion method. Results found that three types had increasing the effect of gentamicin against S. aureus and had not affect against E. coli. Also, increased the potency of gentamicin against S. aureus when combined with garlic, thyme and acacia crud extracts.
Hubungan Pola Makan, Gaya Hidup, Dan Dukungan Keluarga Terhadap Kejadian Anemia Pada Remaja Putri Di Madrasah Tsanawiah Tanwirian Cianjur
Authors: Wahyuni Nita
Published: July 2024

Introduction: Anemia is a nutritional problem that is widely found throughout the world which does not only occur in developing countries but also in developed countries. Young women have a ten times greater risk of suffering from anemia compared to young men. This is because young women experience menstruation every month and are in a period of growth, so they need more iron intake. The impact of the incidence of anemia in adolescents can reduce concentration and academic achievement, as well as affect productivity among adolescents. The general objective of this study was to determine the relationship between diet, lifestyle, and family support for the incidence of anemia in young women at Madrasah Tsanawiah Tanwiriah Cianjur in 2023.
Methods: This study used a quantitative method with a cross-sectional study design. The total population is 176 with a sample of 64 young women.
Results: The results of the univariate statistical test showed that 36 (56,3%) female students had a poor lifestyle; 50 (78,1%) had a poor diet; and 38 (59.4%) had a supportive family. The results of the bivariate analysis found that the p-values ​​of all p-value variables <α (0,05); diet (0,016); lifestyle (0,011); and family support (0,002) mean that Ho is rejected or there is a significant relationship between pattern eating, lifestyle, and family support on the incidence of anemia in young women.
Discussion: This study concludes that diet, lifestyle, and family support have a significant effect on the occurrence of anemia in adolescents, the p-value of diet 0,016 evidences this; lifestyle 0,011; and family support 0,002. Suggestions from the research that has been done, the researcher tries to provide some suggestions to future researchers. With the hope that the suggestions given can be useful in further research.
Perbandingan Pemberian Buah Naga Dan Buah Bit Terhadap Kadar Hb Ibu Hamil Di PMB RY Kecamatan Panongan Kabupaten Tangerang
Authors: Yanti Rom Yul
Published: July 2024

Introduction: Anemia is a factor in maternal mortality. PMB RY Panongan District, Tangerang Regency, the target data for anemic pregnant women in 2020 is 13.6%; in 2021 it is 14.6% and in 2022 it is 15.8%. Prevention of anemia in pregnancy apart from Fe supplements can also be done by consuming foods that contain iron, such as dragon fruit and beets.
 Methods: Quasi-experimental design with pretest-posttest design with control group design. The sample is pregnant women who experience anemia in January-February 2023 as many as 30 samples using a purposive sampling technique. The intervention was given 250g once a day for 14 days. Bivariate analysis used paired sample t-test and independent t-test.
 Results: The results of a Univariate study of Hb levels of pregnant women before the administration of dragon fruit averaged = 10,247 gr/dl and after the administration of dragon fruit averaged = 10,627 gr/dl. Hb levels of pregnant women before the administration of beets averaged = 10,187 gr/dl and after the administration of beets averaged = 11,133 gr/dl. The results of the bivariate study obtained a p-value = 0,000.
 Discussion: There are differences in the effect of giving dragon fruit and beetroot on Hb levels of pregnant women. Pregnant women are expected to be diligent in consuming foods that contain iron, one of which is beetroot and lemon juice, and be obedient in consuming Fe tablets to increase Hb levels in the mother's blood.
Problems in Veterinary Pathology: A Focus on Diagnosis
Authors: Orakpoghenor Ochuko
Published: July 2024

Veterinary pathology is a critical field in veterinary medicine, necessary for the diagnosis of diseases in animals. However, it is faced with numerous challenges that impact the accuracy and efficiency of diagnoses. This manuscript explores into the multifaceted issues within this field, and emphasised on diagnostic challenges. Key areas of concern include the complexity of differentiating between similar pathological conditions, the limitations of current diagnostic tools and techniques, and the variability in the manifestation of diseases across different species. Furthermore, the manuscript highlights the shortage of specialised pathologists, which exacerbates diagnostic delays and errors. Advanced diagnostic technologies, such as molecular pathology and digital imaging, are explored for their potential to enhance diagnostic precision, yet their high cost and limited accessibility present significant barriers. The integration of artificial intelligence and machine learning in veterinary diagnostics is also discussed as a promising avenue to overcome some of these obstacles. Case studies illustrating common diagnostic pitfalls and their consequences on animal health are provided, underscoring the need for continuous education and training in this rapidly evolving field. In conclusion, there is need for a concerted effort to standardise diagnostic procedures and improve collaboration among veterinary pathologists, clinicians, and researchers. By addressing these challenges, the veterinary pathology community can improve diagnostic accuracy, ultimately enhancing animal health outcomes.
THE MARKET OF OILSEEDS OF KAZAKHSTAN IN THE MEDIA: PROBLEMS AND PROSPECTS
Authors: Pritolyuk P. P. , Morozova T. A. , Ponomarenko M. A. , Makarova O. V.
Published: July 2024

This article analyzes the market of oilseeds in Kazakhstan based on information from the media. The study covers the development of the agro-industrial complex of the country, taking into account the gradual reduction of acreage under cereals in favor of oilseeds. The paper examines the opinions of farmers and experts on this strategy, as well as its implementation in the current agricultural season. Special attention is paid to the role of mass media in covering the issues of the oilseed market and the importance of this industry in economic and social terms.The research methodology is based on the analysis of information from the mass media and the assessment of the opinions of agricultural experts.The research methodology is based on the analysis of information from the mass media and the assessment of the opinions of agricultural experts.The main results and analysis allow us to conclude that there is a need for further development of the oilseed market in Kazakhstan, given its importance for the country's economy. The conducted research contributes to the field of knowledge about the development of agriculture and allows us to identify the key problems and prospects of the industry.The practical significance of the work is to provide information about the oilseed market in Kazakhstan, which can be used in planning and developing agricultural development strategies.
INTERNET FRAUD AND ITS IMPACT ON ECONOMIC SECURITY IN THE MODERN WORLD
Authors: Umurzakov I. G. , Protasova О. V. , Salturina А. М.
Published: July 2024

In the modem world, economic security is becoming a key aspect of ensuring stability and development. This article examines the problem of fraud as one of the main threats to economic security. The authors identify various types of fraud, discuss their characteristics and mechanisms of action. Special attention is paid to modern forms of fraud, such as online fraud, and their spread. The article also suggests a number of measures to combat fraud, including educational programs for the population of our country. The need for government intervention and the development of effective strategies to protect the economic interests of citizens and ensure economic security in general is discussed.
INTERESTING CLINICAL CASE: ROLE OF ULTRASOUND DIAGNOSTICS IN DETECTING NEUROENDOCRINE TUMOR OF THE PANCREAS
Authors: Alekseenko I. D.
Published: July 2024

Neuroendocrine tumors of the pancreas today occupy the second place in the prevalence of malignant epithelial tumors of the pancreas [1, p. 132]. Neuroendocrine tumors are divided according to activity into functioning and non-functioning tumors, the latter in turn have the second name “non-secreting” and are more common than functioning tumors. Non-functioning tumors are unfavorable because their growth is slow and a person does not feel symptoms for a long time, but the tumor grows to large sizes, thereby causing symptoms of compression of adjacent anatomical structures [3, p.458]. Neuroendocrine tumors are often diagnosed when they have already metastasized or reached a large size. In view of this, assessment of the tumor load requires the use of several methods of radiation diagnostics: ultrasound, computed tomography, magnetic resonance imaging [2, p.30]. This article will review clinical cases of neuroendocrine tumors using different diagnostic methods.
Monitoring influenza A virus infection in pigs by using a competitive enzyme-linked immunosorbent assay to detect virus antibodies in pen-based oral-fluid specimens
Authors: Strutzberg-Minder Katrin , Boehmer Jan , Fischer Sebastian , Homuth Matthias , Gomez-Duran Oliver , Finger Gudrun , Genzow Marika
Published: July 2024

Objective: To investigate monitoring an influenza A virus (IAV) infection in a finishing pig herd by testing pen-based oral fluids for antibodies against the virus using a commercial enzyme-linked immunosorbent assay (ELISA) kit. Materials and methods: Oral fluids were collected weekly from pigs 12 to 24 or 22 weeks of age in four pens (approximately 25 pigs per pen) in two consecutive batches. Serum samples were also collected from two randomly selected pigs in each pen at 12, 16, and 20 weeks of age in both batches and at 24 weeks in Batch 1 only. Oral-fluid and serum samples were tested for antibodies against IAV by a commercial competitive ELISA test kit. Oral fluids were also tested for IAV by reverse transcription-polymerase chain reaction (RT-PCR). Results: One week after initial detection of IAV in oral-fluid samples by RT-PCR, antibodies against the virus were detected in oral fluids as well as in serum samples. Oral fluids continued to test positive for antibodies 4 to 7 weeks after initial detection of virus, but with a decreasing trend in the amounts of virus antibodies detected by ELISA. All samples in Batch 1 tested negative after 9 weeks. Implications: The longitudinal profile of antibodies against IAV detected in oral fluids promises to be a useful tool for monitoring IAV infection in a pig population. A commercial competitive ELISA test kit could easily be adapted for oral fluids by modifying dilution of the specimen.
ESTRÉS LABORAL Y SALUD MENTAL EN DOCENTES DE EDUCACIÓN SECUNDARIA EN EL CONTEXTO DE LA PANDEMIA COVID-19
Authors: Raymundo Castro Yesica , Paredes Gutarra Madeleine Emperatriz
Published: July 2024

El objetivo de la investigación fue determinar la relación entre estrés laboral y salud mental en docentes de educación secundaria en el contexto de la pandemia COVID-19. Se utilizaron los métodos científico y descriptivo, la técnica de la encuesta con dos instrumentos: Cuestionario de estrés laboral JSS para medir estrés laboral e Inventario de síntomas SCL-90-R de L. Derogatis para medir salud mental. La muestra de estudio estuvo constituida por 50 docentes de educación secundaria de la localidad de Huancavelica-Perú. Los resultados son: El estrés laboral y la salud mental en los docentes de educación secundaria no se relacionan significativamente, aunque se ha encontrado una relación negativa y una relación significativa entre el estrés laboral y los síntomas obsesivos y compulsivos (0.040), con excepción de los síntomas: somatizaciones, sensibilidad interpersonal, depresión, ansiedad , hostilidad, ansiedad fóbica, ideación paranoide y psicotismo, donde no hay una relación significativa con el estrés laboral, a un nivel de confianza del 95% y una significancia de 0.05; sin embargo, se ha evidenciado una relación negativa entre ellas. Por lo tanto, se concluye que, solamente algunos síntomas de la salud mental tienen correspondencia con el estrés laboral.
Exercise as a modality to improve heart transplantation-related functional impairments: An article review
Authors: Nazir Arnengsih
Published: July 2024

Heart transplantation (HT), the treatment choice of advanced heart failure patients, is proven effective in increasing the survival and functional status of the recipients. However, compared to normal controls, functional status is lower in HT recipients. Exercise given in cardiac rehabilitation has been shown to improve exercise capacity as measured with peak oxygen uptake (VO2 peak) and muscle strength after completion of the program and cessation of exercise results in loss of exercise benefits. Several factors related to cardiac denervation and the use of immunosuppressive agents in HT recipients result in functional impairments including cardiovascular, pulmonary, exercise capacity, psychological, and quality of life (QoL) problems. High-intensity interval training (HIIT) is the most common type of exercise used in HT recipients and given as a hospital-based program. Improvement of functional impairments was found to have occurred due to primarily musculoskeletal adaptations through improvement of muscle structure and aerobic capacity and cardiovascular adaptations. In general, exercise given after transplantation improved VO2 peak significantly and improvement was better in the HIIT group compared to moderate intensity continuous training or no-exercise groups. Improvement of QoL was ascribed to improvement of exercise capacity, symptoms, pulmonary function, physical capacity improvement, anxiety, and depression.
Impact of bisphosphonate treatment on bone mineral density after kidney transplant
Authors: Georgopoulou Georgia Andriana , Papasotiriou Marios , Ntrinias Theodoros , Savvidaki Eirini , Goumenos Dimitrios S , Papachristou Evangelos
Published: July 2024

BACKGROUND

Mineral bone disease is associated with chronic kidney disease and persists after kidney transplantation. Immunosuppressive treatment contributes to the pathogenesis of this disease. Bisphosphonate treatments have shown positive but indefinite results.

AIM

To evaluate the effectiveness and safety of bisphosphonate treatment on post kidney transplantation bone mineral density (BMD).

METHODS

We included kidney transplant recipients (KTRs) whose BMD was measured after the operation but before the initiation of treatment and their BMD was measured at least one year later. We also evaluated the BMD of KTRs using two valid measurements after transplantation who received no treatment (control group).

RESULTS

Out of 254 KTRs, 62 (39 men) were included in the study. Bisphosphonates were initiated in 35 KTRs in total (20 men), 1.1 ± 2.4 years after operation and for a period of 3.9 ± 2.3 years while 27 (19 men) received no treatment. BMD improved significantly in KTRs who received bisphosphonate treatments (from -2.29 ± 1.07 to -1.66 ± 1.09, P < 0.0001). The control group showed a non-significant decrease in BMD after 4.2 ± 1.4 years of follow-up after surgery. Kidney function was not affected by bisphosphonate treatment. In KTRs with established osteoporosis, active treatment had a similar and significant effect on those with osteopenia or normal bone mass.

CONCLUSION

In this retrospective study of KTRs receiving bisphosphonate treatment, we showed that active treatment is effective in preventing bone loss irrespective of baseline BMD.
Statin, aspirin and metformin use and risk of hepatocellular carcinoma related outcomes following liver transplantation: A retrospective study
Authors: Chung William , Wong Kevin , Ravindranayagam Noel , Tang Lauren , Grace Josephine , Wong Darren , Con Danny , Sinclair Marie , Majumdar Avik , Kutaiba Numan , Hui Samuel , Gow Paul , Muralidharan Vijayaragavan , Dobrovic Alexander , Testro Adam
Published: July 2024

BACKGROUND

Liver transplantation (LT) is a potentially curative therapy for patients with hepatocellular carcinoma (HCC). HCC-recurrence following LT is associated with reduced survival. There is increasing interest in chemoprophylaxis to improve HCC-related outcomes post-LT.

AIM

To investigate whether there is any benefit for the use of drugs with proposed chemoprophylactic properties against HCC, and patient outcomes following LT.

METHODS

This was a retrospective study of adult patients who received Deceased Donor LT for HCC from 2005-2022, from a single Australian centre. Drug use was defined as statin, aspirin or metformin therapy for ≥ 29 days, within 24 months post-LT. A cox proportional-hazards model with time-dependent covariates was used for survival analysis. Outcome measures were the composite-endpoint of HCC-recurrence and all-cause mortality, HCC-recurrence and HCC-related mortality. Sensitivity analysis was performed to account for immortality time bias and statin dosing.

RESULTS

Three hundred and five patients were included in this study, with 253 (82.95%) males with a median age of 58.90 years. Aetiologies of liver disease were 150 (49.18%) hepatitis C, 73 (23.93%) hepatitis B (HBV) and 33 (10.82%) non-alcoholic fatty liver disease (NAFLD). 56 (18.36%) took statins, 51 (16.72%) aspirin and 50 (16.39%) metformin. During a median follow-up time of 59.90 months, 34 (11.15%) developed HCC-recurrence, 48 (15.74%) died, 17 (5.57%) from HCC-related mortality. Statin, aspirin or metformin use was not associated with statistically significant differences in the composite endpoint of HCC-recurrence or all-cause mortality [hazard ratio (HR): 1.16, 95%CI: 0.58-2.30; HR: 1.21, 95%CI: 0.28-5.27; HR: 0.61, 95%CI: 0.27-1.36], HCC-recurrence (HR: 0.52, 95%CI: 0.20-1.35; HR: 0.51, 95%CI: 0.14-1.93; HR 1.00, 95%CI: 0.37-2.72), or HCC-related mortality (HR: 0.32, 95%CI: 0.033-3.09; HR: 0.71, 95%CI: 0.14-3.73; HR: 1.57, 95%CI: 0.61-4.04) respectively. Statin dosing was not associated with statistically significant differences in HCC-related outcomes.

CONCLUSION

Statin, metformin or aspirin use was not associated with improved HCC-related outcomes post-LT, in a largely historical cohort of Australian patients with a low proportion of NAFLD. Further prospective, multicentre studies are required to clarify any potential benefit of these drugs to improve HCC-related outcomes.
Challenges related to clinical decision-making in hepatocellular carcinoma recurrence post-liver transplantation: Is there a hope?
Authors: Badwei Nourhan
Published: July 2024

Hepatocellular carcinoma (HCC) is a common liver malignancy and represents a serious cause of cancer-related mortality and morbidity. One of the favourable curative surgical therapeutic options for HCC is liver transplantation (LT) in selected patients fulfilling the known standard Milan/University of California San Francisco criteria which have shown better outcomes and longer-term survival. Despite careful adherence to the strict HCC selection criteria for LT in different transplant centres, the recurrence rate still occurs which could negatively affect HCC patients’ survival. Hence HCC recurrence post-LT could predict patients’ survival and prognosis, depending on the exact timing of recurrence after LT (early or late), and whether intra/extrahepatic HCC recurrence. Several factors may aid in such a complication, particularly tumour-related criteria including larger sizes, higher grades or poor tumour differentiation, microvascular invasion, and elevated serum alpha-fetoprotein. Therefore, managing such cases is challenging, different therapeutic options have been proposed, including curative surgical and ablative treatments that have shown better outcomes, compared to the palliative locoregional and systemic therapies, which may be helpful in those with unresectable tumour burden. To handle all these issues in our review.
Grupos de mensajería instantánea entre compañeros de trabajo: intimidad, privacidad y secreto
Authors: Rivas Vallejo Pilar
Published: July 2024

La falta de legitimación para compartir conversaciones privadas en grupos de mensajería instantánea con terceros, incluido el empresario, determina la ilicitud de estas como prueba de incumplimientos a efectos de despido disciplinario y constituye vulneración del derecho a la intimidad, y a la privacidad de las comunicaciones y de los datos personales.
The lack of legitimacy to share private conversations in instant messaging groups with third parties, including the employer, determines the illegality of these as evidence for the purposes of disciplinary dismissal and it constitutes a violation of the right to privacy, the privacy of communications and of personal data.
УПРАВЛЕНИЕ ЭФФЕКТИВНОСТЬЮ ПРОДАЖ И МАРКЕТИНГОВОЙ ДЕЯТЕЛЬНОСТИ В ФАРМИНДУСТРИИ
Authors: Огарков Алексей
Published: July 2024

Развитие и реализация инновационных бизнес-стратегий и ключевых показателей эффективности (KPI) являются важными аспектами управления эффективностью продаж и маркетинговой деятельности в фарминдустрии. В данной статье рассматриваются основные принципы и подходы к определению KPI, а также методы и инструменты, используемые для разработки и реализации инновационных бизнес-стратегий.
Climate Change and Ecosystem Services: A Participatory Approach in a Brazilian Mountainous Region
Authors: Oliveira Samira F. , Prado Rachel B. , Fidalgo Elaine C. C. , Turetta Ana P. D. , Monteiro Joyce M. G. , Pedreira Bernadete da C. C. G. , Antonio Gerson J. Y. , Assis Renato L. de , Oitaven Sandro R. A.
Published: July 2024

Climate change is present in all sectors of global societies, causing various damages, including to agriculture. In this process, understanding the perception of the most affected population and including them in decision-making is a matter of social justice and a more assertive path. Aiming to obtain subsidies for better adaptation to climate change in family farming, this study established a methodology for evaluating the risks of climate change impacts on ecosystem services, related to water and food security, under the perception of rural actors in the mountainous region of the Rio de Janeiro state, Brazil. The methodology consisted of five steps, including the application of the questionnaire to 29 rural actors and ending with validation of the results in a focus group. The main results obtained were that the interviewees perceive the risks of the impacts of climate change in ES, both related to water and food security. Additionally, 24.14% of interviewees mentioned that their family has a monthly income below the Brazilian minimum wage, which exposes their food insecurity. In relation to water security, the risks classified as Very High were mainly in relation to low per capita investments in adaptation policies and infrastructure for environmental protection, between others. The use of many chemical inputs in agriculture also highlighted as a risk to water and food security. Regarding the methodology, it concluded that it was effective in obtaining the perception of the rural actors interviewed regarding the impacts of climate change on ecosystem services at a local scale.
KRITIK SOSIAL DALAM NOVEL KADO TERBAIK KARYA J.S. KHAIREN
Authors: Tiara Tri Dewi
Published: July 2024

Kritik sosial banyak terdapat dalam karya sastra khususnya novel karena melalui novel pengarang dapat menyampaikan masalah-masalah sosial masyarakat ke dalam sebuah cerita yang menarik. Tujuan dari penelitian ini adalah untuk mengetahui kritik sosial yang terdapat pada novel Kado Terbaik karya J.S. Khairen. Penelitian ini menggunakan metode penelitian deskriptif kualitatif. Penelitian ini menggunakan pendekatan sosiologi sastra. Sumber data dari penelitian ini adalah novel yang berjudul Kado Terbaik karya J.S Khairen. Data penelitian berupa satuan-satuan teks yang berupa kutipan, narasi, dan dialog dari novel. Hasil dari penelitian ini adalah adanya kritik sosial berdasarkan pendapat Soerjono Soekanto yang meliputi: (1) kejahatan, (2) kemiskinan, dan (3) disorganisasi keluarga.
PENGARUH KEPERCAYAAN DIRI DAN PENGUASAAN STRUKTUR KALIMAT TERHADAP KETERAMPILAN MENULIS TEKS RECOUNT BAHASA INGGRIS SISWA SEKOLAH MENENGAH PERTAMA SWASTA DI KABUPATEN BEKASI
Authors: Lalan Ruslanudin
Published: July 2024

Tujuan dari penelitian ini adalah untuk mengetahui apakah terdapat pengaruh kepercayaan diri dan penguasaan struktur kalimat secara bersama-sama terhadap keterampilan menulis teks recount bahasa Inggris, untuk mengetahui apakah terdapat pengaruh kepercayaan diri terhadap keterampilan menulis teks recount bahasa Inggris, dan untuk mengetahui apakah terdapat pengaruh penguasaan struktur kalimat terhadap keterampilan menulis teks recount bahasa Inggris, pada siswa SMP swasta di Kabupaten Bekasi. Metode penelitian yang digunakan adalah survei. Sampel berukuran 60 siswa yang dipilih secara acak dari seluruh siswa kelas delapan di SMP Islam Al-Amin berjumlah 180 siswa dan Baiturrahman berjumlah 120 siswa. Pengumpulan data dilaksanakan dengan teknik angket kepercayaan diri, tes struktur kalimat, dan tes menulis teks recount bahasa Inggris. Analisis data terdiri dari analisis statistik deskriptif, uji hipotesis penelitian yaitu analisis korelasi dan regresi ganda, dan uji validitas dan reliabilitas. Hasil penelitian menunjukkan bahwa: (1) Terdapat pengaruh yang tidak signifikan kepercayaan diri dan penguasaan struktur kalimat secara bersama-sama terhadap keterampilan menulis teks recount bahasa Inggris. Hal ini dibuktikan dengan nilai Sig = 0.473 > 0.05 dan Fhitung=0.760, (2) Terdapat pengaruh yang tidak signifikan kepercayaan diri terhadap keterampilan menulis teks recount bahasa Inggris. Hal ini dibuktikan dengan nilai Sig. = 0,942 > 0.05 dan thitung = 0.073,dan (3) Terdapat pengaruh yang tidak signifikan penguasaan struktur kalimat terhadap keterampilan menulis teks recount bahasa Inggris. Hal ini dibuktikan dengan nilai Sig. = 0,227 > 0,05 dan thitung = 1.221.
The Peningkatan Kualitas Human Capital Melalui Pembelajaran Kewirausahaan di SMK Negeri 1 Driyorejo
Authors: Ucik Rachmawati
Published: July 2024

The researcher carried out this research because he wanted to examine how to improve the quality of human capital through entrepreneurship learning at SMKN 1 Driyorejo Gresik. In improving the quality of human capital, one of them is requiring an effective learning, namely by implementing this entrepreneurship. This research uses a qualitative approach that is descriptive and the type of research is a case study. Data collection techniques used by researchers are observing, interviewing and documenting. Meanwhile, data analysis is carried out using data condensation, data presentation, and data verification. In testing the validity of the data, researchers also used source triangulation and technique triangulation. The results of this study show that SMKN 1 Driyorejo Gresik has implemented entrepreneurship learning in creating superior quality human capital so that graduates become entrepreneurship, especially in grades eleven and twelfth. Not only that, SMKN 1 Driyorejo Gresik already has excellent products, namely Skandry Water and Skandry Hygenice. Therefore, it is hoped that all residents of SMKN 1 Driyorejo will apply the KISS method, namely Consolidation, Integration, Synergy and Synchronization so that school plans can be realized and implemented perfectly because they are supported by all school members.
Implementasi Algoritma AES pada Autentikasi Login Sistem Informasi
Authors: Fadlullah Fadlullah  , Muhlis Tahir  , Briliant Pijar Bintari  , Mia Liana Dewi  , Muhammad Fahri Ilmy  , Syafi’ Syafi’  , Rama Ardiansyah
Published: July 2024

The more rapid development of information technology, this has an impact and can cause changes in people's thinking patterns in communicating. In the past, the way people used to communicate remotely was still manual, namely by using letters. The lack of efficiency in sending letters encourages people's mindsets to create innovations that facilitate long-distance communication, namely via SMS, email, WhatsApp and the internet. One of the impacts of the development of message delivery technology is the tapping of data which makes the user feel insecure. One way to secure data breaches is by securing the sender's and recipient's email passwords using AES (Advanced Encryption Standard) cryptography. We conclude that the AES algorithm can be applied to encrypt passwords, so that passwords cannot be easily read by other users. In addition, the password will not be easily cracked.
Meningkatkan Keterampilan Membaca Pada Anak Sekolah Dasar Kelas Tinggi Dengan Menggunakan Metode PQ4R (Preview, Question, Read, Reflect, Recite, Review)
Authors: Adien Inayah  , Fadillah Annisak  , Pramudia Ananda  , Riska Rahman Tanjung  , Siti Fadilla
Published: July 2024

This study aims to determine the effectiveness of using the PQ4R (Preview, Question, Read, Reflect, Recite, Review) method in improving reading skills in elementary school children in high grades.  The research method used in this research uses qualitative methods with a literature study approach.  Research with literature or literature study is a data collection technique by conducting a review of books, literature, records and various reports related to the problem to be solved to reach a conclusion.  This study provides recommendations for educators and education practitioners to consider using the PQ4R (Preview, Question, Read, Reflect, Recite, Review) method to improve reading skills in high school elementary school children.  Proper and integrated implementation of the use of this method can be an effective alternative in developing students reading skills and creating a more meaningful learning experience in the learning process at school.  The results showed that the use of the PQ4R method (Preview, Question, Read, Reflect, Recite, Review) can significantly improve students skills in reading but there are also some drawbacks when using the PQ4R method (Preview, Question, Read, Reflect, Recite, Review).  This method relies on the performance of the brain's memory so that it can improve student understanding, because at this stage of the method carrying out reading activities repeatedly, the information obtained will stick in the students memory longer.  While this method is not effective in a small amount of time because this method requires a lot of time, especially at the read stage.
Education Pengaruh Model Pembelajaran Rms Terhadap Kemampuan Berpikir Kritis Siswa Pada Materi Virus
Authors: Yanwar Habibul Muttaqin  , Nisa Sholehah Pangsuma  , Sri Hartati  , Asrianty Mas’ud
Published: July 2024

This research is based on a problem found in one of the Madrasah Aliyah schools, namely the model used is not diverse enough that it is considered boring. When learning accepts students feel bored and bored. So that learning activities in class tend to be more rigid and passive. The purpose of this study was to analyze students' responses to the model. learning RMS (Reading, Mind mapping, and Sharing) on ​​Virus material. The research method used is Quasi Experimental (Quasi Experimental). Obtaining data in this study showed that the average student response was 77% in the good category. Thus it can be concluded that students' responses to the RMS learning model (Reading, Mind mapping, and Sharing) on ​​Virus material can be used because it is more fun so it can be used as an alternative. Students are expected to have the same opportunity to develop, and it is recommended that research is conducted to examine more deeply. more about student responses. against models. RMS learning (Reading, Mind mapping, and Sharing) on ​​other Virus materials.
Peran Kegiatan Ekstrakurikuler Dalam Pembinaan Dan Pengembangan Siswa Sekolah Dasar
Authors: Intan Oktaviani Agustina  , Juliantika Juliantika  , Selly Ade Saputri  , Syahla Rizkia Putri N
Published: July 2024

The role of extracurricular activities in the guidance and development of students in elementary schools is very important in providing a holistic and in-depth learning experience outside the ordinary academic environment. The purpose of this study was to find out the role of extracurriculars in fostering and developing students at SD 186 Cipadung and SD Al-Ma'soem. This study uses a qualitative method that produces and processes descriptive data such as interview transcripts. The results of this study show that extracurricular roles instill character values ​​such as hard work, discipline, teamwork, leadership, and responsibility. In addition, extracurricular roles can develop students' potential interests and talents.
Pengembangan Materi pembelajaran Keberagaman Budaya Menumbuhkan Kesetiaan Terhadap Tanah Air pada Siswa Kelas IV SD
Authors: Nurlaila Ramadhani  , Ramanda Putri Mardiyyana  , Tin Rustini
Published: July 2024

This article is constructed around the discoveries made during the research, where it was found that the character of love for one's country is not yet fully implied in the souls of students. There are still many students who lack discipline in doing and submitting assignments, not only that, there are also many students who speak inappropriately and are impolite to their classmates and those above them, and never care about friends who are experiencing difficulties. The role of learning media is very crucial in helping students understand learning material. To develop learning materials, of course learning media is needed as a supporting tool when learning takes place, with learning media being able to develop material on cultural diversity to increase love for the country, especially focused on class students.