bluuebunny/crossref_metadata_2025 huggingface dataset:
The impact of confinement in the psychosocial behaviour due COVID-19 among members of a Brazilian university
Authors: Amaral-Prado Heloísa Monteiro , Borghi Filipy , Mello Tânia Maron Vichi Freire , Grassi-Kassisse Dora Maria
Published: November 2020

Background:

The current situation due COVID-19 may cause an eminent impact on mental health because the confinement restrictions.

Aims:

The aim of this study was to analyze and compare perceived stress, resilience, depression symptoms and coping strategies on the members of University of Campinas, in Brazil, before and during the outbreak of the COVID-19.

Methods:

Volunteers over 18 years of both sexes, members of the University of Campinas (Unicamp) in Brazil answered instruments related to perceived stress, depression, resilience and coping strategies during final exams at the end of semester during 2018 to 2020.

Results:

We obtained 1,135 responses (893 before COVID-19 and 242 during COVID-19). The volunteers did not show significant differences for perceived stress, depressive signs and resilience before and during the pandemic. In both periods, men exhibited lower scores for perceived stress and depression and higher scores for resilience when compared to women. Undergraduate and graduate students exhibited higher perceived stress scores, more pronounced depressive signs and lower resilience, and employees and professors presented lower scores for perceived stress, depressive signs and greater resilience.

Conclusions:

These first months of confinement did not directly affect the scores of perceived stress, depression and resilience, however, each subgroup adapted to the new routine by changing the coping strategy used. This study suggests the importance of monitoring the mental health of member in the university, especially in times of epidemic, in the search for policies that aim to improve the resilience of the population and seek positive and effective coping strategies within the university environment.
The role of hybridisation and fibre architecture on the post-impact flexural behaviour of composite laminates
Authors: Dalfi Hussein , Babu-Katnum Kali , Potluri Prasad , Selver Erdem
Published: November 2020

Advanced composite materials are widely used in civil and military applications due to their superior specific strength and stiffness. However, they are susceptible to damage during impact loading. In order to improve the impact performance, yarn hybridisation and fibre architecture have been investigated in this study in order to evaluate their influence on the damage tolerance (i.e. post- impact flexural strength) of glass composite laminates. Two types of yarn have been used here, namely, pure glass yarns as a bench-mark and hybrid yarns (glass-polypropylene) to manufacture non-crimp and woven (twill and satin) fabric composites. The composite laminates were then subjected to low-velocity impact tests at various impact energies. Afterwards, post- impact flexural strength has been evaluated with a four-point bending test. It has been observed that the non-crimp and woven hybrid composites laminates displayed smaller damage areas compared to the non-crimp glass composites laminates. In addition, although the hybrid laminates have exhibited lower flexural strength properties than the non-crimp glass laminates, the former has shown higher post-impact flexural strength. Fractography analysis has suggested here that the damage failure modes such as intra-yarn cracks have been produced in the hybrid yarns laminates and intra-yarn and inter-yarn cracks have been produced in hybrid fabric laminates. These damage failures have contributed for absorbing impact energy leading to an enhancement of the damage tolerance of the hybrid laminates.
WWP2 Promotes Odontoblastic Differentiation by Monoubiquitinating KLF5
Authors: Fu J. , Zheng H. , Xue Y. , Jin R. , Yang G. , Chen Z. , Yuan G.
Published: November 2020

WW domain-containing E3 Ub-protein ligase 2 (WWP2) belongs to the homologous to E6AP C-terminus (HECT) E3 ligase family. It has been explored to regulate osteogenic differentiation, chondrogenesis, and palatogenesis. Odontoblasts are terminally differentiated mesenchymal cells, which contribute to dentin formation in tooth development. However, it remained unknown whether WWP2 participated in odontoblast differentiation. In this study, WWP2 was found to be expressed in mouse dental papilla cells (mDPCs), odontoblasts, and odontoblastic-induced mDPCs by immunohistochemistry and Western blotting. Besides, WWP2 expression was decreased in the cytoplasm but increased in the nuclei of differentiation-induced mDPCs. When Wwp2 was knocked down, the elevated expression of odontoblast marker genes ( Dmp1 and Dspp) in mDPCs induced by differentiation medium was suppressed. Meanwhile, a decrease of alkaline phosphatase (ALP) activity was observed by ALP staining, and reduced formation of mineralized matrix nodules was demonstrated by Alizarin Red S staining. Overexpression of WWP2 presented opposite results to knockdown experiments, suggesting that WWP2 promoted odontoblastic differentiation of mDPCs. Further investigation found that WWP2 was coexpressed and interacted with KLF5 in the nuclei, leading to ubiquitination of KLF5. The PPPSY (PY2) motif of KLF5 was essential for its physical binding with WWP2. Also, cysteine 838 (Cys838) of WWP2 was the active site for ubiquitination of KLF5, which did not lead to proteolysis of KLF5. Then, KLF5 was confirmed to be monoubiquitinated and transactivated by WWP2, which promoted the expression of KLF5 downstream genes Dmp1 and Dspp. Deletion of the PY2 motif of KLF5 or mutation of Cys838 of WWP2 reduced the upregulation of Dmp1 and Dspp. Besides, lysine (K) residues K31, K52, K83, and K265 of KLF5 were verified to be crucial to WWP2-mediated KLF5 transactivation. Taken together, WWP2 promoted odontoblastic differentiation by monoubiquitinating KLF5.
Can (Instructions About) Stimulus Pairings Influence Automatic and Self-Reported Evaluations in the Presence of More Diagnostic Evaluative Information?
Authors: Moran Tal , Van Dessel Pieter , Smith Colin Tucker , De Houwer Jan
Published: November 2020

Evaluative conditioning (EC) and persuasion are important pathways for shaping evaluations. However, little is known about how these pathways interact. Two preregistered experiments (total N = 1,510) examined effects of EC procedures (i.e., stimulus pairings) and EC instructions (i.e., instructions about stimulus pairings) on automatic and self-reported evaluations of social groups in the presence of more diagnostic information about the evaluative traits of those groups. Interestingly, both EC procedures and EC instructions still influenced automatic and self-reported evaluations when participants had read more diagnostic persuasive information. In line with predictions of propositional accounts of evaluation, EC instruction effects on automatic evaluations were not mediated by corresponding changes in self-reported evaluations. These results have theoretical implications and also highlight the important role that (instructions about) stimulus pairings have in social learning.
Beliefs About Self-Compassion: Implications for Coping and Self-Improvement
Authors: Chwyl Christina , Chen Patricia , Zaki Jamil
Published: November 2020

Self-compassion—treating oneself with care and understanding during difficult times—promotes adaptive coping and self-improvement. Nonetheless, many people are not self-compassionate. We examined a key barrier people face to treating themselves self-compassionately: their negative beliefs about self-compassion (i.e., that it leads to complacency, indulgence, or irresponsibility). Across three studies, the more people held these negative beliefs, the less self-compassionately they reported responding to a real-world event (Study 2) and hypothetical emotional challenges (Studies 1 and 3). Self-compassionate responding, in turn, predicted adaptive coping strategies and intentions for self-improvement. Experimentally inducing people to hold positive, as opposed to negative, beliefs about self-compassion predicted self-compassionate responding 5 to 7 days later (Study 3). By recognizing and targeting peoples’ beliefs, our findings highlight the importance of reducing such beliefs that are barriers to practicing self-compassion, as a means to improve the way people respond to difficult times.
Muscimol-induced inactivation of the anterior cingulate cortex does not impair trace fear conditioning in the rat
Authors: Pezze Marie A , Marshall Hayley J , Cassaday Helen J
Published: November 2020

Previous studies suggest that trace conditioning depends on the anterior cingulate cortex (ACC). To examine the role of ACC in trace fear conditioning further, 48 rats were surgically prepared for infusion with saline or 62.5 or 125 µg/side muscimol to inactivate ACC reversibly prior to conditioning. A noise stimulus was followed by a 1 mA footshock, with or without a 10-second trace interval between these events in a conditioned suppression procedure. The trace-conditioned groups (10 seconds) showed less test suppression than the control-conditioned groups (0 seconds). Counter to prediction, there was no effect of muscimol infusion on suppression to the noise stimulus in the 10-second trace groups.
Effects of miR-146a-5p on chondrocyte interleukin-1β-induced inflammation and apoptosis involving thioredoxin interacting protein regulation
Authors: Zhao Guigui , Gu Wei
Published: November 2020

Objective

Osteoarthritis (OA) is a chronic degenerative arthropathy characterized by articular cartilage degeneration, subchondral osteosclerosis, and hyperosteogeny. MicroRNAs (miRNAs) play an important regulatory role in its pathological development, so this study explored the effect and potential mechanism of miR-146a-5p in interleukin (IL)-1β-induced OA cartilage injury.

Methods

The human chondrosarcoma cell line SW1353 and normal human chondrocytes C28/I2 were stimulated by IL-1β to construct the OA chondrocyte model. miR-146a-5p and thioredoxin interacting protein (TXNIP) expression levels were detected by quantitative real-time (qRT)-PCR and western blot. Their expression was modified by transfecting an miR-146a-5p inhibitor, mimic, and pcDNA-TXNIP. The relationship between miR-146a-5p and TXNIP was analyzed by the dual-luciferase assay, while cell viability, apoptosis, and inflammatory expression were determined by cell counting, TUNEL staining, and ELISA, respectively.

Results

miR-146a-5p expression was upregulated in SW1353 and C28/I2 cells stimulated by IL-1β. miR-146a-5p knockdown significantly enhanced cell activity, inhibited inflammatory factor expression, and reduced cell apoptosis. The dual-luciferase assay revealed TXNIP as a target gene of miR-146a-5p and suggested that miR-146a-5p promotion of OA damage could be reversed by upregulating TXNIP.

Conclusion

These results suggest that miR-146a-5p inhibits cell proliferation and promotes apoptosis and the inflammatory response in OA cartilage injury by modulating TXNIP.
The Circadian Clock and Viral Infections
Authors: Borrmann Helene , McKeating Jane A , Zhuang Xiaodong
Published: November 2020

The circadian clock controls several aspects of mammalian physiology and orchestrates the daily oscillations of biological processes and behavior. Our circadian rhythms are driven by an endogenous central clock in the brain that synchronizes with clocks in peripheral tissues, thereby regulating our immune system and the severity of infections. These rhythms affect the pharmacokinetics and efficacy of therapeutic agents and vaccines. The core circadian regulatory circuits and clock-regulated host pathways provide fertile ground to identify novel antiviral therapies. An increased understanding of the role circadian systems play in regulating virus infection and the host response to the virus will inform our clinical management of these diseases. This review provides an overview of the experimental and clinical evidence reporting on the interplay between the circadian clock and viral infections, highlighting the importance of virus-clock research.
Internal leakage analysis and experiment in hydraulic control system of steam turbine inlet valve
Authors: Liu Ying , Wang Qimin , Li Xiaoxiao , Wang Liming
Published: November 2020

In this paper, the transformation of steam turbine regulating system from mechanical hydraulic regulation to electro-hydraulic regulation is realized. And the internal leakage mechanism of the hydraulic control switch valve and the electro-hydraulic proportional valve in the system is analyzed. With the use of hydraulic simulation software AMESim, the mathematical model of the electro-hydraulic control system after transforming is established. The parameters of the hydraulic control switch valve and the electro-hydraulic proportional valve in the hydraulic control system of steam turbine inlet valve are studied under different internal leakage locations and different leakage degree, such as piston regulating time, steady position of piston, oil pressure and leakage flow flux. The fault characteristic table of internal leakage is obtained. An experimental platform for simulating internal leakage is built. The experimental curves of several physical quantities under different internal leakage conditions are obtained. The experimental results prove that the internal leakage has a great impact on the performance of the electro-hydraulic control system. The results of internal leakage experiment are consistent with those of internal leakage simulation.
From Stress to Depression: Bringing Together Cognitive and Biological Science
Authors: LeMoult Joelle
Published: November 2020

One of the most consistent findings in the depression literature is that stressful life events predict the onset and course of depressive episodes. Cognitive and biological responses to life stressors have both been identified, albeit largely independently, as central to understanding the association between stress and depression. I maintain that the largest advances in the understanding of depression will come from examining the ways that cognitive and biological responses to stressors reciprocally influence one another and, in doing so, contribute to the onset and maintenance of depression. I summarize the cognitive and biological stress responses implicated in depression and then describe the reciprocal ways that they are associated with each other. Finally, I discuss the broader implications of taking this integrated approach and suggest directions and considerations for future research.
A ‘mere six weeks’? A comparative study re-examining the longevity of infantry officers’ frontline service during the Great War
Authors: Thorpe Tom
Published: November 2020

Veteran testimony after the Great War and current popular legend states that regimental officers in frontline infantry battalions during the Great War served around six weeks before death or injury ended their service. This article seeks to explore the veracity of these assertions by conducting a quantitative statistical survey of the longevity of officers who served in eight British and two Canadian infantry battalions on the Western Front during the Great War. The data presented in this study debunks the idea of the ‘six weeks’ myth as only 7 per cent of all episodes of service were six weeks or less. During 1914/1915, officers served on average just over five months, and this nearly doubled by 1918. Even during the intensive fighting of the Hundred Days in 1918, officers’ length of service was found to be longer than in earlier in the war. The increasing longevity of officer service over the course of the war may have been as a result of cumulative battlefield learning, support from experienced non-commissioned officers, the introduction of the left-out-of-battle system and tactical reform of platoons that made the platoon officer a co-ordinator rather than a personal leader. In addition, from 1916, the majority of officers joining infantry units under study were commissioned from the ranks and brought with them years of battlefield experience and military service which helped them survive.
The role of personality and self-efficacy in music students’ health-promoting behaviours
Authors: Cohen Susanna , Panebianco Clorinda
Published: November 2020

Evidence of the high prevalence of physical and psychological problems among professional and student classical musicians has led to investigations of music students’ health-promoting behaviours. These have indicated lower levels of engagement in health-promoting behaviours among music students compared to non-music students and resulted in the recent introduction of health education courses in a number of tertiary music education institutions. Investigations of health-promoting behaviours in a wide range of contexts have shown that personality and general self-efficacy are significantly associated with health-promoting behaviours. Although previous studies of music students’ health-promoting behaviours provide evidence of positive associations between general self-efficacy and health-promoting behaviours, the contribution of personality to health-promoting behaviours and the influence of general self-efficacy on the associations between personality and music students’ health-promoting behaviours have not yet been investigated. The current study examined associations between the personality, general self-efficacy, and health-promoting behaviours of 154 undergraduate music students. Hierarchical regression analyses showed that Conscientiousness was the most consistent significant predictor of health-promoting behaviours. Conscientiousness, Extraversion, and Neuroticism were found to predict general self-efficacy. Mediation analyses were carried out and showed that general self-efficacy mediated the associations between both Conscientiousness and Neuroticism, and health-promoting behaviours. The implications of the findings for future health education courses are discussed.
Systemic mastocytosis with subcutaneous hemorrhage and edema in a Greyhound dog: case report and review of diagnostic criteria
Authors: Aceino Alexander , Jeffery Unity , Piccione Julie , Hodo Carolyn L.
Published: November 2020

Systemic mastocytosis, characterized by infiltration of multiple organs by neoplastic mast cells, is a well-described entity in human medicine with specific criteria for diagnosis, but is ill defined in veterinary literature. Hemostatic disorders are reported in humans affected by systemic mastocytosis but have not been well described in veterinary literature. A 5-y-old, spayed female Greyhound dog had a 1-mo history of progressive ventral cutaneous edema, hemorrhage, and pain. Cytology of an antemortem aspirate from the subcutis of the ventral abdomen was suggestive of mast cell neoplasia, but no discrete mass was present. The dog was euthanized and submitted for autopsy; marked subcutaneous edema and hemorrhage were confirmed. The ventral abdominal panniculus and dermis superficial to the panniculus carnosus were infiltrated by a dense sheet of neoplastic mast cells. The neoplastic cells contained toluidine blue–positive granules and formed aggregates within the bone marrow and several visceral organs, including the liver, spleen, heart, and kidney. Diffuse edema and hemorrhage is an unusual presentation of mast cell tumors in dogs. Antemortem tests, including complete blood count, coagulation profile, and viscoelastic coagulation testing, were suggestive of a primary hemostatic defect. We discuss here the diagnostic criteria used in humans, how these can be applied to veterinary patients, and the limitations of the current diagnostic framework.
Advanced Care Planning and End-of-life Outcomes in Hematopoietic Stem Cell Transplant Patients
Authors: Cooper Alexandra , Dains Joyce E.
Published: November 2020

Aim/Purpose:

This integrative review addresses whether the presence and timing of advanced care planning (ACP) with or without a palliative care (PC) consultation affect place of death and use of high-intensity medical care at end-of-life (EOL) in adolescent and young adult and adult cancer patients receiving hematopoietic stem cell transplant (HSCT) therapy.

Methods and Results:

A literature search was completed in the Scopus and PubMed databases. The search was not restricted by date but was restricted to English language. A total of 1,616 articles were found, and after exclusion of duplicates and irrelevance, 79 articles were available to review. After reviewing inclusion and exclusion criteria, 9 articles related to ACP with HSCT were found, and 4 were eliminated after further review, resulting in 5 viable articles for review related to EOL outcomes. EOL outcomes reviewed were place of death and high-intensity medical care. Factors noted to influence these measures included the presence or absence of ACP, the timing of ACP, and PC consultation. Overall survival also emerged as an EOL outcome affected by ACP.

Conclusion:

Although there have been many barriers identified to ACP discussions in the HSCT population, the findings from the integrative literature review support the use of early ACP with patients who have hematologic malignancies undergoing HSCT to address patient EOL goals and reduce healthcare utilization at the EOL. The data also suggest that identification of patients who would most benefit from early engagement in ACP may positively impact outcomes.
Childhood Abuse and Cognitive Function in a Large Cohort of Middle-Aged Women
Authors: Roberts Andrea L. , Sumner Jennifer A. , Koenen Karestan C. , Kubzansky Laura D. , Grodstein Francine , Rich-Edwards Janet , Weisskopf Marc G.
Published: November 2020

Cognitive function at middle age is of particular public health interest, as it strongly predicts later dementia. Children who have experienced abuse subsequently have worse cognitive function than those who have not. However, it remains unclear whether the association of abuse with cognitive function persists into middle age. In 2014–2016, 14,151 women ages 49–69 years who had previously responded to a childhood abuse questionnaire completed a cognitive battery. In models adjusted for childhood socioeconomic status and head trauma, combined physical, emotional, and sexual abuse was associated with lower scores on both Learning/Working Memory (severe abuse, lower scores similar to that observed in women 4.8 years older in our data) and Psychomotor Speed/Attention (severe abuse, lower scores similar to that observed in women to 2.9 years older in our data). Adjustment for adulthood socioeconomic status and health factors (e.g., smoking, hypertension) slightly attenuated associations. In exploratory analyses further adjusted for psychological distress, associations were attenuated. Women exposed versus unexposed to childhood abuse had poorer cognitive function at mid-life. Associations were particularly strong for learning and working memory and were not accounted for by adulthood health factors. Childhood abuse should be investigated as a potential risk factor for cognitive decline and dementia in old age.
Retro or Renewal: An Assessment of PPP Management and Policy in China Since 2014
Authors: Cai Jianming , Lin Jing , Yang Zhenshan , Zhou Xinfa , Cheng Zhe
Published: November 2020

Since 2014, public–private partnerships (PPPs) in China have experienced an impulsive new boom with a new PPP policy that has drawn wide attention domestically and internationally. In particular, development characteristics and performance assessments of projects in the new PPP boom are a hot topic. By comparing China’s PPP development in the last several years with that in the past thirty years, we explore its rationale and performance through a critical review using the following approach: first, we identify and analyze its seven new characteristics of investment scale, spatial distribution, investment sectors, operational model, concession period, payment mechanism, and tendering period; second, we diagnose the nature and performance of the new PPP boom; third, we systematically scrutinize the rationale behind the characteristics and the possible mechanism; and last, we conclude with the argument that the new PPP boom could be well managed by the Chinese government if some prerequisites are met. We also raise some key issues inviting more comprehensive comparative studies. This study contributes to the existing literature by providing a project-data-analysis lens to better understand PPP development in China and worldwide. The implementation of this study will not only enrich global PPP knowledge, but will also be a good reference for PPP practice and trends in China and other developing countries.
Needling after XEN gel implant: What’s the efficacy? A 1-year analysis
Authors: José Patrícia , Teixeira Filipa Jorge , Barão Rafael Correia , Sens Paula , Abegão Pinto Luís
Published: November 2020

Purpose:

To analyse the long-term efficacy and safety of bleb needling in glaucoma patients previously submitted to XEN implantation.

Methods:

Retrospective, observational study. Charts from patients who underwent XEN gel implant surgery between October 2015 and December 2017 were reviewed. Needling protocol involves use of Mitomycin C 0.2 mg/mL in an operating room. Primary outcome was defined as intraocular pressure (IOP) lowering efficacy at 12 months post-operative. Complete success was defined as a decrease in IOP > 20% and overall value <18 mmHg. Secondary outcomes included safety parameters (both intra and post-operative). Exploratory analysis of predictive factors for success were performed. Statistical analysis was performed using SPSS version 24.

Results:

About 94 charts were reviewed, with 18 patients (19%) having undergone needle revision. This salvage procedure was performed after 3.3 ± 3.4 months, achieving a mean IOP reduction of 8.3 ± 8.4 mmHg at 12 months after the procedure (pre-needling: 24.0 ± 5.2 mmHg vs 12th month: 13.5 ± 5.9 mmHg, p < 0.0001). Accordingly, success was achieved in 72% (complete success in 61% of cases). Among predictive factors, there was a higher tendency for success in patients on two types of medications or fewer pre-operatively, cases of standalone XEN surgery and patients with a higher IOP difference pre-needling – day 1. No vision-threatening complications were recorded.

Conclusion:

XEN salvage procedure with mitomycin C is a valid option in early bleb failure. This single intervention had a long-lasting effect on bleb survival, with almost two-thirds achieving long term significant drop-free IOP reduction.
Validation of mobile-based funduscope for diabetic retinopathy screening in Estonia
Authors: Krieger Birgit , Hallik Riina , Kala Kristina , Ülper Karina , Polonski Margarita
Published: November 2020

Aim:

To validate mobile-based funduscope for diabetic retinopathy screening in Estonia.

Methods:

Quality validation comparison of HEINE® iC2 funduscope and Zeiss Visucam camera with image scoring and diagnostic test accuracy measurement by sensitivity and specificity. Study took place from January 2020 until March 2020 in East-Tallinn Central Hospital’s eye clinic.

Results:

Based on 90 patients, the Zeiss Visucam showed 35.6% DR prevalence while iC2 had 18.9% for images and 17.8% for videos. The average Likert score was 4.7 for Zeiss Visucam and 2.4 for both iC2 images and iC2 videos. The sensitivity of iC2 images was 72.7% (95%CI 49.6–88.4) for grader 1 and 61.9% (95%CI 38.7–81.0) for grader 2, iC2 video sensitivity was 57.1% (95%CI 37.4–75.0) and 65.4% (95%CI 44.4–82.1), respectively. The grader-based specificity for iC2 images was 96.7% (95%CI 80.9–99.8) and 93.5% (95%CI 77.2–98.9). iC2 videos had a 100% (95%CI 91.7–1.0; 92.0–1.0) specificity by both graders. Cohen’s kappa agreement was 0.82 and 0.96 for images and videos.

Conclusion:

Mobile-based funduscope iC2 is not valid for DR screening with non-dilated pupils and thus not suitable for clinics that do not have experienced specialist present. Moreover, the screening specialist needs to be experienced fundus photographer with extra multiple day training for funduscope use. As main resolution, mobile-based funduscope was not validated for DR screening in Estonia based on pre-set study criteria. Additional research and development of funduscope algorithm for image stripping from videos is needed for validation as iC2 benefits do not offset the gold standard at the moment.
Safety and feasibility of upper limb vascular access for cardiac catheterization in anticoagulated and non-anticoagulated patients
Authors: Marques Felipe Pereira Lima , Valle Felipe Homem , Araujo Gustavo Neves de , Pinheiro Machado Guilherme , Amantea Rodrigo , Fuchs Felipe C , Bergoli Luiz Carlos , Goncalves Sandro Cadaval , Wainstein Marco , Wainstein Rodrigo
Published: November 2020

Background:

The upper limb approach utilizing transradial access for combined left and right heart catheterization (CLRHC) and ultrasound-guided antecubital venous access for isolated right heart catheterization (IRHC) are strategies that may reduce risks, especially in anticoagulated patients. combined left and right heart catheterization

Objectives:

To assess safety and feasibility of upper limb approach for IRHC or CLRHC in anticoagulated versus non-anticoagulated patients.

Methods:

Ninety-three patients who underwent IRHC or CLRHC with ultrasound-guided antecubital venous access and transradial arterial access were prospectively enrolled. The primary outcome was a composite of procedure failure and incidence of immediate vascular complications.

Results:

Of the 93 patients, 44 (47%) were on anticoagulation and 49 (53%) were not. Mean age was 54 ± 17 and 53 ± 15 years, respectively. Atrial fibrillation (39% vs 15%) and chronic kidney disease (21% vs 6%) were more common in anticoagulated patients. The main indication for anticoagulation was deep vein thrombosis/pulmonary thromboembolism in 22 patients (50%). The primary outcome occurred in 4 (8%) patients in the non-anticoagulated group as compared with 0 in the anticoagulated group ( p = 0.12). Procedure failure occurred in two patients (4%) and immediate vascular complications in two patients (4%) in the non-anticoagulated group ( p = 0.3 for all). There was no difference between groups regarding duration of the procedure, radiation dose, fluoroscopy time, post-procedure recovery room time and median time to venous or arterial hemostasis.

Conclusions:

The upper limb approach for heart catheterization had similar rates of procedure failure and immediate vascular complications in anticoagulated patients when compared to non-anticoagulated patients.
Passive vibration reduction of a squeeze film damper for a rotor system with fit looseness between outer ring and housing
Authors: Wang Haifei
Published: November 2020

Clearances between bearing outer ring and sleeve can generally be maintained to provide a margin for the thermal expansion of the bearings. However, temperature variation, improper assembly and long-term vibration can enlarge the clearances and accelerate mechanical wear, leading to what is known as the fit looseness fault. Therefore, it is important to study a fit looseness fault model and investigate how to control the vibration coming from the fit looseness fault. In this paper, a Jeffcott rotor system with three disks was modeled as a single unit. A fit looseness model was applied in the whole rotor model to study the contact problems and response characteristics using a numerical integration method. Then, a squeeze film damper model was applied to assess the vibration reduction effects on the whole rotor system with the fit looseness fault. By comparing the results of the fit looseness fault without squeeze film damper and with squeeze film damper, it is found that the squeeze film damper can reduce nonlinear vibration responses effectively generated by the fit looseness fault for the nonlinear contact. This research work contributes to understanding the mechanism of fit looseness fault and controlling strong nonlinear vibration responses due to the fit clearances.
Permanent deformation limits of long-span track cable-stayed bridges based on service performance analysis
Authors: Li Xiaogang , Gao Mangmang , Zhou Jianting , Chen Xiaohu , Tan Shulin
Published: November 2020

With the continuous service time, long-span track cable-stayed bridges are inevitably affected by material time-varying and fatigue load periodic effects, and permanent down-deflection phenomenon is inevitable. The down-deflection of the main girder would lead to the irregularity of bridge deck, which would directly affect the running comfort and safety of the train. The permanent deformation control value should be set reasonably. In this paper, based on the research and analysis of domestic and foreign codes and standards, the evaluation criteria for the service performance of long-span track cable-stayed bridges was determined, aiming at the problem of deformation classification control in the service stage of the long-span track cable-stayed bridge. The limit of permanent deformation of main girder was analyzed, and the decision processing was put forward and applied to an engineering example. According to the vehicle-bridge coupling vibration analysis, the maximum vertical deformation safety control value in the service stage is L/400, and the pre-warning control value is L/500. With the non-permanent deformation value β deducted, the permanent deformation safety control value is L/400- β, and the pre-warning control value is L/500- β. The rationality of the grading control limit of permanent deformation based on service performance analysis has been verified by application analysis.
‘Overflown bodies’ as critical-political transformations
Authors: Enguix Grau Begonya
Published: November 2020

In order to explore the political and transformative potential of bodies in relation to gender and affects, I discuss how bodies, gender and politics are entangled through the figuration of ‘overflown bodies’. Departing from a material-discursive feminist conceptualisation of bodies, ‘overflown bodies’ are assemblages embedded in complex relationships of matter, discourse, emotions, affects, ideologies, protest, norms, values, relations, practices, expectations and other possibilities of (for) social and political action. Three ethnographic cases illustrate how ‘overflown bodies’ assemble matter and discourse, and how matter, bodies and gender matter. They are used to explore the political possibilities of gendered bodies and show how matter is entangled, embedded and assembled with our politics of being. The three cases interrogate the limits and boundaries of bodies and the modes and modalities of (political) agency. Finally, the article argues that it is through visibility and recognition that ‘overflown bodies’ become critically and creatively transforming, which can be useful for addressing issues related to exclusion, domination, political emancipation and social transformation.
Scaling proximity to whiteness: Racial boundary-making on São Tomé Island
Authors: Bouchard Marie-Eve
Published: November 2020

In this article, I examine how scales are produced, stabilized, and challenged through communicative practices, and how these scales organize (since colonial times) the racial groups that form Santomean society. I argue that the historical distinctive status of the Forros and the prestigious status of the Portuguese language are influenced by different scaling practices that are intertwined and interrelated. I demonstrate that it is the Forros’ imagined and historical proximity to whiteness that bestow them racial privilege, and that allows them to maintain their position of social and political power in the country. In other words, their power results from proximity to Whiteness.
Biomechanical energy harvest based on textiles used in self-powering clothing
Authors: Niu Li , Miao Xuhong , Jiang Gaoming , Wan Ailan , Li Yutian , Liu Qing
Published: November 2020

Advanced triboelectric nanogenerator techniques provide a massive opportunity for the development of new generation wearable electronics, which toward multi-function and self-powering. Textiles have been refreshed with the requirement of flexible electronics in recent decades. In particular, knitted-textiles have exhibited enormous and prominent potential possibilities for smart wearable devices, which are based on the merits of high stretchability, excellent elasticity, comfortability as well as compatibility. Combined knitted textiles with nanogenerator techniques will promote the knitted textile triboelectric nanogenerators (KNGs) emerging, endowing conventional textiles with biomechanical energy harvesting and sensing energy supplied abilities. However, the design of KNGs and the construction of KNGs are based on features of human motions symbolizing considerable challenges in both high efficiency and excellent comfort. Currently, this review is concerned with KNGs construction account of triboelectric effects referring to knitted-textile classifications, structural features, human motion energy traits, working mechanisms, and practical applications. Moreover, the remaining challenges of industrial production and the future prospects of knitted-textile triboelectric nanogenerators of harvesting biomechanical energy are presented.
Recognizing barriers to entry of biosimilars in the United States market and highlighting the solutions
Authors: Bana Arpit , Mehta Priti J
Published: November 2020

Drugs that are procured from living cells and are used to treat acute and chronic diseases are called biologics, whereas biosimilars are the drugs which are highly similar but not identical to the original reference product. The main advantage of these drugs is that they are highly targeted with great therapeutic activity and can be used for multiple indications. Despite all the advantages biologics are still extremely costly. The main purpose of developing and introducing biosimilars was and is to increase market competition leading to a decrease in the cost of the biologics. However, until now the cost of the treatment has not decreased in the US market because there are many barriers to the entry of biosimilar in the US market which are discussed in this article. In this article, we argue that the barrier or hurdle in the US market entry of the biosimilars is not only limited to patent protection or exclusivity but other less discussed barriers are also there which are to be discussed. Due to these barriers till June 10, 2020, only 9 biosimilars are available commercially in the US market out of the 27 biosimilars approved for marketing by the U.S. Food and Drug Administration (FDA). We argue that the introduction of these biosimilars in the US market is essential for increasing market competition and thus decreasing the overall treatment cost for both the government and the payers. In this article, we are also providing perspective on the possible solutions to reduce these barriers and to encourage the entry of biosimilar in the US market.
Intravenous brexanolone for postpartum depression: what it is, how well does it work, and will it be used?
Authors: Faden Justin , Citrome Leslie
Published: November 2020

Postpartum depression is considered to be a subtype of major depressive disorder that occurs in approximately 10–20% of mothers worldwide. However, in actuality, these numbers are likely underreported due to minimization and the stigma of mental illness. Until recently, there were no approved medications for the treatment of postpartum depression. Allopregnanolone is a naturally occurring neuroactive steroid whose serum levels decline precipitously following childbirth. This hormonal fluctuation has been postulated as playing a role in the pathophysiology of postpartum depression. Brexanolone is the first medication approved by the US Food and Drug Administration for the treatment of postpartum depression. Brexanolone is an intravenous proprietary formulation of allopregnanolone that can be administered to produce stable serum levels comparable with third-trimester concentrations in postpartum mothers. It is hypothesized to modulate neuronal excitability by functioning as an allosteric modulator of γ-aminobutyric acid-A receptors and is administered under monitoring as a 60 h continuous infusion. In this review, we will highlight the results of the clinical trial program, including efficacy and tolerability data. Practical and logistical considerations of brexanolone will be reviewed, as will its potential place in therapy for the treatment of postpartum depression.
Has Blog Reader–Focused Research Evolved?
Authors: Elega Adeola Abdulateef , Özad Bahire Efe , Oloyede Felix , Omisore Olabola Taye , Abu Arqoub Omar
Published: November 2020

For many years, researchers interested in the blogosphere have collectively acknowledged the lack of scholarly attention into the role of blog readers in the blogging activity. While many pioneering studies as well as new studies have highlighted the rising potential of this field, there has been no systematic examination of the growth or lack thereof of this field. As a result, this article reviews blog reader–focused research between 2008 and 2018 through a content analysis of blog reader–focused research articles obtained from seven databases: EBSCO’s Academic Search Complete, JSTOR, EBSCO’s Communication & Mass Media Complete, SAGE Journals, Elega’s Chronological Arrangement of Blog Readership Research, Wiley Online Library, and Taylor and Francis. We also identified the methods, theories, geospatial concentration, and journals that published these articles. Findings show that although at least one article was published each year with a peak of six in 2013 and 2015, blog reader–focused research has not really evolved given that concentration has tremendously decreased in the last 3 years (2016–2018). Regarding genres, we learnt that the majority of articles focused on political blogs, and most of the studies adopted quantitative research methods and survey as a data collection method. The results also show that blog reader–focused studies published between 2008 and 2018 used Uses and Gratification Theory more than other theories, and the majority of these articles focused on blogs in the United States. Journal of Computer-Mediated Communication, New Media &Society, and Computers in Human Behavior published more blog reader–focused research than other journals.
“I Am Grateful That I Still Live Under One Roof With My Family”: Gratitude Among South African University Students
Authors: du Plessis Carolina F. , Guse Tharina , du Plessis Graham A.
Published: November 2020

During the transition from school to university, students are faced with many challenges to their well-being. This is especially true in resource constrained societies like South Africa. While there is extensive research linking well-being with gratitude, less is known qualitatively about what individuals are grateful for. A sample of 933 undergraduate students submitted gratitude lists, resulting in over 9,000 unique “gratitude items.” Thematic analysis revealed several prominent themes, such as gratitude for relationships, material resources, being at university, life and health, and, finally, religious gratitude. These themes are discussed in the context of the importance of family relationships in the lives of emerging adults, the core role played by the educational context, the importance of socioeconomic resources and the association between religion, gratitude, and well-being. Strengthening these resources and cultivating gratitude for these prominent targets of appreciation may support students in their developmental trajectory.
High-Quality Green-Emitting Nanodiamonds Fabricated by HPHT Sintering of Polycrystalline Shockwave Diamonds
Authors: Osipov Vladimir Yu. , Shakhov Fedor M. , Bogdanov Kirill V. , Takai Kazuyuki , Hayashi Takuya , Treussart François , Baldycheva Anna , Hogan Benjamin T. , Jentgens Christian
Published: November 2020

We demonstrate a high-pressure, high-temperature sintering technique to form nitrogen-vacancy-nitrogen centres in nanodiamonds. Polycrystalline diamond nanoparticle precursors, with mean size of 25 nm, are produced by the shock wave from an explosion. These nanoparticles are sintered in the presence of ethanol, at a pressure of 7 GPa and temperature of 1300 °C, to produce substantially larger (3–4 times) diamond crystallites. The recorded spectral properties demonstrate the improved crystalline quality. The types of defects present are also observed to change; the characteristic spectral features of nitrogen-vacancy and silicon-vacancy centres present for the precursor material disappear. Two new characteristic features appear: (1) paramagnetic substitutional nitrogen (P1 centres with spin ½) with an electron paramagnetic resonance characteristic triplet hyperfine structure due to the I = 1 magnetic moment of the nitrogen nuclear spin and (2) the green spectral photoluminescence signature of the nitrogen-vacancy-nitrogen centres. This production method is a strong alternative to conventional high-energy particle beam irradiation. It can be used to easily produce purely green fluorescing nanodiamonds with advantageous properties for optical biolabelling applications.
Correction to: Feasibility and efficacy of lung ultrasound to investigate pulmonary complications in patients who developed postoperative Hypoxaemia-a prospective study
Authors: Xie Chen , Sun Kai , You Yueyang , Ming Yue , Yu Xiaoling , Yu Lina , Huang Jiapeng , Yan Min
Published: November 2020

An amendment to this paper has been published and can be accessed via the original article.
Barriers to effective prescribing in older adults: applying the theoretical domains framework in the ambulatory setting – a scoping review
Authors: Lau Sabrina , Lun Penny , Ang Wendy , Tan Keng Teng , Ding Yew Yoong
Published: November 2020

Background

As the population ages, potentially inappropriate prescribing (PIP) in the older adults may become increasingly prevalent. This undermines patient safety and creates a potential source of major morbidity and mortality. Understanding the factors that influence prescribing behaviour may allow development of interventions to reduce PIP. The aim of this study is to apply the Theoretical Domains Framework (TDF) to explore barriers to effective prescribing for older adults in the ambulatory setting.

Methods

A scoping review was performed based on the five-stage methodological framework developed by Arksey and O’Malley. From 30 Aug 2018 to 5 Sep 2018, we conducted our search on PubMed, CINAHL, EMBASE, the Cochrane Database of Systematic Reviews, and Web of Science. We also searched five electronic journals, Google and Google Scholar to identify additional sources and grey literature. Two reviewers applied eligibility criteria to the title and abstract screening, followed by full text screening, before systematically charting the data.

Results

A total of 5731 articles were screened. Twenty-nine studies met the selection criteria for qualitative analysis. We mapped our results using the 14-domain TDF, eventually identifying 10 domains of interest for barriers to effective prescribing. Of these, significant domains include physician-related factors such as “Knowledge”, “Skills”, and “Social/Professional Role and Identity”; issues with “Environmental Context and Resources”; and the impact of “Social Influences” and “Emotion” on prescribing behaviour.

Conclusion

The TDF elicited multiple domains which both independently and collectively lead to barriers to effective prescribing for older adults in the ambulatory setting. Changing the prescribing climate will thus require interventions targeting multiple stakeholders, including physicians, patients and hospital/clinic systems. Further work is needed to explore individual domains and guide development of frameworks to aid guide prescribing for older adults in the ambulatory setting.