bluuebunny/crossref_metadata_2025 huggingface dataset:
Attitudes to Noise Inside Dwellings in Three Megacities: Seoul, London, and São Paulo
Authors: Lee Pyoung Jik , Hopkins Carl , Penedo Rafaella
Published: August 2020

This study investigated people’s attitudes towards noise inside their homes. Online questionnaire surveys were conducted in Seoul, London, and São Paulo. The questionnaire was designed to assess annoyance caused by noise from neighbours and environmental noise (transportation). Information was also collected on situational, personal, and socio-demographic variables. Respondents that were more annoyed by outdoor noise inside their dwelling reported higher neighbour noise annoyance. In Seoul, neighbour noise was found to be more annoying than outdoor noise, and those with higher noise sensitivity reported higher annoyance towards neighbour noise. However, neighbour noise and outdoor noise was found to be equally annoying in London and São Paulo. For neighbour noise, the average percentage of respondents hearing structure-borne sources compared to airborne sources differed in each city. Most neighbour noise sources in São Paulo gave rise to higher annoyance ratings than Seoul and London. Education and income levels had a limited effect on annoyance and coping strategy. Annoyance with indoor noise from neighbours was found to have stronger relationships with cognitive and behavioural coping strategies than outdoor noise annoyance.
The Needs and Utilization of Long-Term Care Service Resources by Dementia Family Caregivers and the Affecting Factors
Authors: Chang Chia-Hui , Ming Yung , Chang Tsung-Hung , Yen Yea-Yin , Lan Shou-Jen
Published: August 2020

This study was to evaluate the utilization of long-term care service resources by caregivers of patients with dementia (PWD) and to determine affecting factors. In this cross-sectional study, a total of 100 dyads were enrolled and caregivers responded to the questionnaires. We found 40% of caregivers not using any care resources. Between those caregivers using and not-using care resources, we found differences (p < 0.05) in their health status and living conditions; the difference (p < 0.05) was also found in patients’ behavior and psychological symptoms of dementia (BPSD). The frequency of BPSD (OR = 1.045, p = 0.016, 95% CI = 1.001–1.083) and the living conditions (OR = 3.519, p = 0.007, 95% CI = 1.414–8.759) were related to their use of care resources. Particular BPSDs, such as anxiety or restlessness, throwaway food, aggressive behavior, tearing of clothes, and sexual harassment of patients were related to the caregivers’ use of care resources (p < 0.01). Health professionals have to evaluate the patients’ BPSD and identify the caregivers’ essential needs. Individualized medical care and BPSD-related care resources should be provided for patients and caregivers for taking off their care burden and improving patient care.
Polycyclic Aromatic Hydrocarbons in the Estuaries of Two Rivers of the Sea of Japan
Authors: Chizhova Tatiana , Koudryashova Yuliya , Prokuda Natalia , Tishchenko Pavel , Hayakawa Kazuichi
Published: August 2020

The seasonal polycyclic aromatic hydrocarbon (PAH) variability was studied in the estuaries of the Partizanskaya River and the Tumen River, the largest transboundary river of the Sea of Japan. The PAH levels were generally low over the year; however, the PAH concentrations increased according to one of two seasonal trends, which were either an increase in PAHs during the cold period, influenced by heating, or a PAH enrichment during the wet period due to higher run-off inputs. The major PAH source was the combustion of fossil fuels and biomass, but a minor input of petrogenic PAHs in some seasons was observed. Higher PAH concentrations were observed in fresh and brackish water compared to the saline waters in the Tumen River estuary, while the PAH concentrations in both types of water were similar in the Partizanskaya River estuary, suggesting different pathways of PAH input into the estuaries. The annual riverine PAH mass flux amounted to 0.028 t/year and 2.5 t/year for the Partizanskaya River and the Tumen River, respectively. The riverine PAH contribution to the coastal water of the Sea of Japan depends on the river discharge rather than the PAH level in the river water.
Psychosocial Determinants of Quality of Life and Active Aging. A Structural Equation Model
Authors: León Laura Ponce de , Mangin Jean Pierre Lévy , Ballesteros Soledad
Published: August 2020

Population aging is the 21st century’s predominant demographic event. The old-age dependency ratio is projected to rise sharply in the next decades. Variables of health-related quality of life can be useful in designing interventions for promoting active aging to prevent dependency and save governments’ budgets. This study aims to find a model capable of explaining how psychosocial variables are related to improved quality of life during active aging, and if this relationship varies with age. Structural equation modelling (SEM) was used to examine the relationships among the availability of social resources, memory, depression, and perception of quality of life from three community senior centers in Madrid (Spain) in a sample of 128 older adult volunteers. The results suggest a psychosocial model where the availability of social support improves quality of life and explicit memory, reduces depression in active older adults, and where there are two main elements for understanding quality of life: perception of health and satisfaction. Importantly, age does not modify the interactions between variables, suggesting that their behavior is constant across aging. We concluded that the availability of social resources, understood not only as the people we interact with daily but also other family members, close friends, or institutions that could help in case of an emergency, allows people to avoid isolation and loneliness, increasing satisfaction and well-being in older adults. Professionals and policymakers should promote well-being by incorporating psychosocial variables related to personal satisfaction in the existential project, not only health, functional activity, or a friendly environment. Older adults need to feel that they are not alone, and in this sense, the availability of social resources is key.
Incentivizing Commuter Cycling by Financial and Non-Financial Rewards
Authors: Máca Vojtěch , Ščasný Milan , Zvěřinová Iva , Jakob Michal , Hrnčíř Jan
Published: August 2020

Current mobility patterns over-rely on transport modes that do not benefit sustainable and healthy lifestyles. To explore the potential for active mobility, we conducted a randomized experiment aimed at increasing regular commuter cycling in cities. In designing the experiment, we teamed up with developers of the “Cyclers” smartphone app to improve the effectiveness of the app by evaluating financial and non-financial motivational features. Participants in the experiment were recruited among new users of the app, and were randomly assigned to one of four different motivational treatments (smart gamification, two variants of a financial reward, and a combination of smart gamification and a financial reward) or a control group (no specific motivation). Our analysis suggests that people can be effectively motivated to engage in more frequent commuter cycling with incentives via a smartphone app. Offering small financial rewards seems to be more effective than smart gamification. A combination of both motivational treatments—smart gamification and financial rewards—may work the same or slightly better than financial rewards alone. We demonstrate that small financial rewards embedded in smartphone apps such as “Cyclers” can be effective in nudging people to commute by bike more often.
COVID-19 Pandemic Brings a Sedentary Lifestyle in Young Adults: A Cross-Sectional and Longitudinal Study
Authors: Zheng Chen , Huang Wendy Yajun , Sheridan Sinead , Sit Cindy Hui-Ping , Chen Xiang-Ke , Wong Stephen Heung-Sang
Published: August 2020

The coronavirus disease 2019 (COVID-19) pandemic continues to pose profound challenges to society. Its spread has been mitigated through strategies including social distancing; however, this may result in the adoption of a sedentary lifestyle. This study aimed to investigate: (1) physical activity (PA) levels, sedentary behavior (SB), and sleep in young adults during the COVID-19 epidemic, and (2) the change in these behaviors before and during the pandemic. A total of 631 young adults (38.8% males) aged between 18 and 35 participated in the cross-sectional study and completed a one-off online survey relating to general information, PA, SB, and sleep. For the longitudinal study, PA, SB, and sleep data, obtained from 70 participants before and during the COVID-19 pandemic, were analyzed. Participants engaged in low PA, high SB, and long sleep duration during the COVID-19 pandemic. Moreover, a significant decline in PA while an increase in time spent in both SB and sleep was observed during the COVID-19 outbreak. The results of this study demonstrated a sedentary lifestyle in young adults during the COVID-19 pandemic, which will assist health policymakers and practitioners in the development of population specific health education and behavior interventions during this pandemic and for other future events.
China’s Carbon Emissions and Trading Pilot, Political Connection, and Innovation Input of Publicly Listed Private Firms
Authors: Liu Wei , Yu Chunquan , Cheng Shixiong , Xu Jingyi , Wu Yuzhao
Published: August 2020

Taking China’s carbon emissions and trading pilot (CCETP) as a quasi-natural experiment, this paper examines the impact of CCETP on publicly listed private firms’ innovation input and the moderating effect of the firms’ political connection based on the difference-in-differences model. The results show that CCETP has a significantly positive effect on the innovation input of Chinese publicly listed private firms. Moreover, the political connection of executives exhibits a positive moderating effect on CCETP’s impact on innovation input. Meanwhile, the effect is more significant in regions with high environmental protection investment and large publicly listed private firms. The conclusions could provide some policy enlightenment for China’s carbon market, as well as a rational adjustment of the relationship between political connection and innovation input of publicly listed private firms in the future.
Recent Advances in Molecular Research in Rice: Agronomically Important Traits
Authors: Hori Kiyosumi , Shenton Matthew
Published: August 2020

Rice (Oryza sativa L [...]
Impact of Extracellular Vesicle Isolation Methods on Downstream miRNA Analysis in Semen: A Comparative Study
Authors: Mercadal Marina , Herrero Carolina , López-Rodrigo Olga , Castells Manel , de la Fuente Alexandre , Vigués Francesc , Bassas Lluís , Larriba Sara
Published: August 2020

Seminal plasma (SP) contains a unique concentration of miRNA, mostly contained in small extracellular vesicles (sEVs) such as exosomes, some of which could be clinically useful for diagnosis and/or prognosis of urogenital diseases such as prostate cancer (PCa). We optimized several exosome-EV isolation technologies for their use in semen, evaluating EV purifying effectiveness and impact on the downstream analysis of miRNAs against results from the standard ultracentrifugation (UC) method to implement the use of SP sEV_miRNAs as noninvasive biomarkers for PCa. Our results evidenced that commercial kits designed to isolate exosomes/EVs from blood or urine are mostly applicable to SP, but showed quantitative and qualitative variability between them. ExoGAG 3500× g and the miRCURY Cell/Urine/CSF 1500× g methods resulted as equivalent alternative procedures to UC for isolating exosomes/sEVs from semen for nanoparticle characteristics and quality of RNA contained in vesicles. Additionally, the expression profile of the altered semen sEV-miRNAs in PCa varies depending on the EV isolation method applied. This is possibly due to different extraction techniques yielding different proportions of sEV subtypes. This is evidence that the exosome-EV isolation method has a significant impact on the analysis of the miRNAs contained within, with important consequences for their use as clinical biomarkers. Therefore, miRNA analysis results for EVs cannot be directly extrapolated between different EV isolation methods until clear markers for delineation between microvesicles and exosomes are established. However, EV extraction methodology affects combined models (semen exosome miRNA signatures plus blood Prostate specific antigen (PSA) concentration for PCa diagnosis) less; specifically our previously described (miR-142-3p + miR-142-5p + miR-223-3p + PSA) model functions as molecular marker from EVs from any of the three isolation methods, potentially improving the efficiency of PSA PCa diagnosis.
Normoxic Tumour Extracellular Vesicles Modulate the Response of Hypoxic Cancer and Stromal Cells to Doxorubicin In Vitro
Authors: Patras Laura , Fens Marcel H. A. M. , Vader Pieter , Barendrecht Arjan , Sesarman Alina , Banciu Manuela , Schiffelers Raymond
Published: August 2020

Extracellular vesicles (EV) secreted in the tumour microenvironment (TME) are emerging as major antagonists of anticancer therapies by orchestrating the therapeutic outcome through altering the behaviour of recipient cells. Recent evidence suggested that chemotherapeutic drugs could be responsible for the EV-mediated tumour–stroma crosstalk associated with cancer cell drug resistance. Here, we investigated the capacity of tumour EV (TEV) secreted by normoxic and hypoxic (1% oxygen) C26 cancer cells after doxorubicin (DOX) treatment to alter the response of naïve C26 cells and RAW 264.7 macrophages to DOX. We observed that C26 cells were less responsive to DOX treatment under normoxia compared to hypoxia, and a minimally cytotoxic DOX concentration that mounted distinct effects on cell viability was selected for TEV harvesting. Homotypic and heterotypic pretreatment of naïve hypoxic cancer and macrophage-like cells with normoxic DOX-elicited TEV rendered these cells slightly less responsive to DOX treatment. The observed effects were associated with strong hypoxia-inducible factor 1-alpha (HIF-1α) induction and B-cell lymphoma–extra-large anti-apoptotic protein (Bcl-xL)-mediated anti-apoptotic response in normoxic DOX-treated TEV donor cells, being also tightly connected to the DOX-TEV-mediated HIF-1α induction, as well as Bcl-xL levels increasing in recipient cells. Altogether, our results could open new perspectives for investigating the role of chemotherapy-elicited TEV in the colorectal cancer TME and their modulatory actions on promoting drug resistance.
Metformin as a Potential Agent in the Treatment of Multiple Sclerosis
Authors: Dziedzic Angela , Saluk-Bijak Joanna , Miller Elzbieta , Bijak Michal
Published: August 2020

Metformin, a synthetic derivative of guanidine, is commonly used as an oral antidiabetic agent and is considered a multi-vector application agent in the treatment of other inflammatory diseases. Recent studies have confirmed the beneficial effect of metformin on immune cells, with special emphasis on immunological mechanisms. Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) characterized by various clinical courses. Although the pathophysiology of MS remains unknown, it is most likely a combination of disturbances of the immune system and biochemical pathways with a disruption of blood–brain barrier (BBB), and it is strictly related to injury of intracerebral blood vessels. Metformin has properties which are greatly desirable for MS therapy, including antioxidant, anti-inflammatory or antiplatelet functions. The latest reports relating to the cardiovascular disease confirm an increased risk of ischemic events in MS patients, which are directly associated with a coagulation cascade and an elevated pro-thrombotic platelet function. Hence, this review examines the potential favourable effects of metformin in the course of MS, its role in preventing inflammation and endothelial dysfunction, as well as its potential antiplatelet role.
Microglial Phagocytosis—Rational but Challenging Therapeutic Target in Multiple Sclerosis
Authors: Pinto Maria V. , Fernandes Adelaide
Published: August 2020

Multiple sclerosis (MS) is the most common autoimmune and demyelinating disease of the central nervous system (CNS), characterized, in the majority of cases, by initial relapses that later evolve into progressive neurodegeneration, severely impacting patients’ motor and cognitive functions. Despite the availability of immunomodulatory therapies effective to reduce relapse rate and slow disease progression, they all failed to restore CNS myelin that is necessary for MS full recovery. Microglia are the primary inflammatory cells present in MS lesions, therefore strongly contributing to demyelination and lesion extension. Thus, many microglial-based therapeutic strategies have been focused on the suppression of microglial pro-inflammatory phenotype and neurodegenerative state to reduce disease severity. On the other hand, the contribution of myelin phagocytosis advocating the neuroprotective role of microglia in MS has been less explored. Indeed, despite the presence of functional oligodendrocyte precursor cells (OPCs), within lesioned areas, MS plaques fail to remyelinate as a result of the over-accumulation of myelin-toxic debris that must be cleared away by microglia. Dysregulation of this process has been associated with the impaired neuronal recovery and deficient remyelination. In line with this, here we provide a comprehensive review of microglial myelin phagocytosis and its involvement in MS development and repair. Alongside, we discuss the potential of phagocytic-mediated therapeutic approaches and encourage their modulation as a novel and rational approach to ameliorate MS-associated pathology.
Targeting E3 Ubiquitin Ligases and Deubiquitinases in Ciliopathy and Cancer
Authors: Shiromizu Takashi , Yuge Mizuki , Kasahara Kousuke , Yamakawa Daishi , Matsui Takaaki , Bessho Yasumasa , Inagaki Masaki , Nishimura Yuhei
Published: August 2020

Cilia are antenna-like structures present in many vertebrate cells. These organelles detect extracellular cues, transduce signals into the cell, and play an essential role in ensuring correct cell proliferation, migration, and differentiation in a spatiotemporal manner. Not surprisingly, dysregulation of cilia can cause various diseases, including cancer and ciliopathies, which are complex disorders caused by mutations in genes regulating ciliary function. The structure and function of cilia are dynamically regulated through various mechanisms, among which E3 ubiquitin ligases and deubiquitinases play crucial roles. These enzymes regulate the degradation and stabilization of ciliary proteins through the ubiquitin–proteasome system. In this review, we briefly highlight the role of cilia in ciliopathy and cancer; describe the roles of E3 ubiquitin ligases and deubiquitinases in ciliogenesis, ciliopathy, and cancer; and highlight some of the E3 ubiquitin ligases and deubiquitinases that are potential therapeutic targets for these disorders.
Interplay between Peripheral and Central Inflammation in Obesity-Promoted Disorders: The Impact on Synaptic Mitochondrial Functions
Authors: Crispino Marianna , Trinchese Giovanna , Penna Eduardo , Cimmino Fabiano , Catapano Angela , Villano Ines , Perrone-Capano Carla , Mollica Maria Pina
Published: August 2020

The metabolic dysfunctions induced by high fat diet (HFD) consumption are not limited to organs involved in energy metabolism but cause also a chronic low-grade systemic inflammation that affects the whole body including the central nervous system. The brain has been considered for a long time to be protected from systemic inflammation by the blood–brain barrier, but more recent data indicated an association between obesity and neurodegeneration. Moreover, obesity-related consequences, such as insulin and leptin resistance, mitochondrial dysfunction and reactive oxygen species (ROS) production, may anticipate and accelerate the physiological aging processes characterized by systemic inflammation and higher susceptibility to neurological disorders. Here, we discussed the link between obesity-related metabolic dysfunctions and neuroinflammation, with particular attention to molecules regulating the interplay between energetic impairment and altered synaptic plasticity, for instance AMP-activated protein kinase (AMPK) and Brain-derived neurotrophic factor (BDNF). The effects of HFD-induced neuroinflammation on neuronal plasticity may be mediated by altered brain mitochondrial functions. Since mitochondria play a key role in synaptic areas, providing energy to support synaptic plasticity and controlling ROS production, the negative effects of HFD may be more pronounced in synapses. In conclusion, it will be emphasized how HFD-induced metabolic alterations, systemic inflammation, oxidative stress, neuroinflammation and impaired brain plasticity are tightly interconnected processes, implicated in the pathogenesis of neurological diseases.
Autonomous System for Wildfire and Forest Fire Early Detection and Control
Authors: Ferreira Luís Miguel , Coimbra A. Paulo , de Almeida Aníbal T.
Published: August 2020

Recurring and increasing large-scale wildfires across the globe (e.g., Southern Europe, California, Australia), as a result of worsening climate conditions with record temperatures, drought, and strong winds, present a challenge to mankind. Early fire detection is crucial for a quick reaction and effective firefighting operations, minimizing the risk to human lives as well as the destruction of assets, infrastructures, forests, and wildlife. Usually, ground firefighting relies on human intervention and dangerous exposition to high temperatures and radiation levels, proving the need for mechanisms and techniques to remotely or autonomously detect and combat fire. This paper proposes an autonomous firefighting system built with a motorized water turret, narrow beam far infrared (FIR) sensors, and a micro-controller running novel algorithms and techniques. Experimental field results validated the technical approach, indicating that when a small fire front is within the field of view of the FIR sensor and within the range of the water jet, it is possible to provide an early alarm and even autonomously extinguish or delay the approaching fire front, increasing the chance for evacuation.
Review of Fuel Cell Technologies and Applications for Sustainable Microgrid Systems
Authors: Akinyele Daniel , Olabode Elijah , Amole Abraham
Published: August 2020

The shift from centralized to distributed generation and the need to address energy shortage and achieve the sustainability goals are among the important factors that drive increasing interests of governments, planners, and other relevant stakeholders in microgrid systems. Apart from the distributed renewable energy resources, fuel cells (FCs) are a clean, pollution-free, highly efficient, flexible, and promising energy resource for microgrid applications that need more attention in research and development terms. Furthermore, they can offer continuous operation and do not require recharging. This paper examines the exciting potential of FCs and their utilization in microgrid systems. It presents a comprehensive review of FCs, with emphasis on the developmental status of the different technologies, comparison of operational characteristics, and the prevailing techno-economic barriers to their progress and the future outlook. Furthermore, particular attention is paid to the applications of the FC technologies in microgrid systems such as grid-integrated, grid-parallel, stand-alone, backup or emergency power, and direct current systems, including the FC control mechanisms and hybrid designs, and the technical challenges faced when employing FCs in microgrids based on recent developments. Microgrids can help to strengthen the existing power grid and are also suitable for mitigating the problem of energy poverty in remote locations. The paper is expected to provide useful insights into advancing research and developments in clean energy generation through microgrid systems based on FCs.
Riluzole Oral Suspension for the Treatment of Amyotrophic Lateral Sclerosis: Texture and Compatibility with Food Thickeners Evaluation
Authors: Colombo Giuseppe , Artico Roberta , Barbareschi Daniele
Published: August 2020

Riluzole 5 mg/mL oral suspension is the only licensed liquid medicine to treat Amyotrophic Lateral Sclerosis (ALS) orally. As more than 80% of ALS patients develop dysphagia, an oral liquid formulation provides an important therapeutic option. The Riluzole 5 mg/mL oral suspension is administered by means of the graduated oral dosing syringe included in the medicine package. Its concentration (5 mg/mL) is consistent with a small and easy to measure volume (10 mL) to deliver the prescribed 50-mg dose twice daily. This work had a dual objective. The first was to evaluate the texture of the Riluzole 5 mg/mL oral suspension according to the International Dysphagia Diet Standardisation Initiative (IDDSI) flow test. Results of this experiment indicated that Riluzole 5 mg/mL oral suspension would basically fall under the “mildly thick” IDDSI descriptors. This is an important feature because thick fluids facilitate a safer swallow in patients with dysphagia. As a second objective, we evaluated for scientific purposes the compatibility of Riluzole 5 mg/mL oral suspension with some of the most common food thickeners available on the market. Intimate mixtures of the Riluzole 5 mg/mL oral suspension with thickeners were evaluated for appearance, pH, Riluzole assay and Riluzole related substances immediately after preparation and after two hours at room temperature. Riluzole 5 mg/mL oral suspension resulted to be compatible with all the marketed thickeners tested.
The Environmental Assessment of an Estuarine Transitional Environment, Southern Italy
Authors: Arienzo Michele , Bolinesi Francesco , Aiello Giuseppe , Barra Diana , Donadio Carlo , Stanislao Corrado , Ferrara Luciano , Mangoni Olga , Toscanesi Maria , Giarra Antonella , Trifuoggi Marco
Published: August 2020

A multidisciplinary survey was carried out on the quality of water and sediments of the estuary of the Sele river, an important tributary of the Tyrrhenian Sea, to assess anthropogenic pressures and natural variability. Nine sediment sites were monitored and analyzed for granulometry, morphoscopy, benthic foraminifera and ostracod assemblages, heavy metals, and polycyclic aromatic hydrocarbons. Surface water was assayed for ionic composition and phytoplankton biomass. Total organic carbon (TOC) and total nitrogen (TN) in sediments were higher in the inner part of the estuary (IE), up to 12.7 and 0.7% because of anthropic influence. In waters, N-NH4, N-NO3, and Ptot. were high, with loads of Ptot in IE exceeding ~fourfold the limit. Here, it was also observed that the highest primary production was Chl-a, 95.70 µg/L, with cryptophytes, 37.6%, and diatoms, 33.8%, being the main phytoplanktonic groups. The hierarchical analysis split the estuary into two areas, with marked differences in anthropic pollution. Waters were classified as poor–bad level with respect to the content of nutrients. Sedimentological assay reveals littoral erosion and poor supply of river sandy sediments. The erosion environment is confirmed by the presence of meiobenthic recent marine forms intrusion inside the river. All these data reveal the fragility of the estuary and the need of urgent remediation actions.
Predicting the Impact of COVID-19 on Australian Universities
Authors: Thatcher Arran , Zhang Mona , Todoroski Hayden , Chau Anthony , Wang Joanna , Liang Gang
Published: August 2020

This article explores the impact of the novel coronavirus (COVID-19) upon Australia’s education industry with a particular focus on universities. With the high dependence that the revenue structures of Australian universities have on international student tuition fees, they are particularly prone to the economic challenges presented by COVID-19. As such, this study considers the impact to total Australian university revenue and employment caused by the significant decline in the number of international students continuing their studies in Australia during the current pandemic. We use a linear regression model calculated from data published by the Australian Government’s Department of Education, Skills, and Employment (DESE) to predict the impact of COVID-19 on total Australian university revenue, the number of international student enrolments in Australian universities, and the number of full-time equivalent (FTE) positions at Australian universities. Our results have implications for both policy makers and university decision makers, who should consider the need for revenue diversification in order to reduce the risk exposure of Australian universities.
Environmental Pollution Control and Sustainability Management of Slum Settlements in Makassar City, South Sulawesi, Indonesia
Authors: Surya Batara , Saleh Haeruddin , Suriani Seri , Sakti Harry Hardian , Hadijah Hadijah , Idris Muhammad
Published: August 2020

The complexity of spatial use has an impact on poverty and the development of slum settlements towards a decrease in environmental quality. In this study, we aim to analyze (1) urbanization and spatial expansion as determinants of spatial dynamics in suburban areas, (2) the effect of spatial expansion, land use change, population increase, and spatial activity patterns on the development of slum settlements, and (3) the relationship between control of spatial planning, handling land reclamation, and improving the quality of infrastructure with improving the quality of the environment and the sustainability of handling slum settlements in the suburbs. We use a sequential explanatory design, which is a combination of quantitative and qualitative research, and data are obtained through observation, in-depth interviews, surveys, and documentation. The results showed that slum settlements in watersheds and coastal areas as well as inadequate support for infrastructure services resulted in excessive groundwater use, soil pollution, and surface water quality pollution resulting in less smooth river flow regulation, lowering of water levels, urban flooding, and disease transmission. Weak control over spatial use, utilization of water catchment areas, and the inadequate fulfillment of slum settlement infrastructure services cause a decrease in environmental quality. These results indicate that it is very important to deal with slum settlements in a sustainable manner, including spatial use and environmental, economic, and social aspects. This study recommends that the handling of slum settlements requires policy support from the government in an effort, to meet the city target without slums by 2030 in Makassar City, Indonesia.
Neural-Impulsive Pinning Control for Complex Networks Based on V-Stability
Authors: Ríos-Rivera Daniel , Alanis Alma Y. , Sanchez Edgar N.
Published: August 2020

In this work, a neural impulsive pinning controller for a twenty-node dynamical discrete complex network is presented. The node dynamics of the network are all different types of discrete versions of chaotic attractors of three dimensions. Using the V-stability method, we propose a criterion for selecting nodes to design pinning control, in which only a small fraction of the nodes is locally controlled in order to stabilize the network states at zero. A discrete recurrent high order neural network (RHONN) trained with extended Kalman filter (EKF) is used to identify the dynamics of controlled nodes and synthesize the control law.
The Application of Stock Index Price Prediction with Neural Network
Authors: Gao Penglei , Zhang Rui , Yang Xi
Published: August 2020

Stock index price prediction is prevalent in both academic and economic fields. The index price is hard to forecast due to its uncertain noise. With the development of computer science, neural networks are applied in kinds of industrial fields. In this paper, we introduce four different methods in machine learning including three typical machine learning models: Multilayer Perceptron (MLP), Long Short Term Memory (LSTM) and Convolutional Neural Network (CNN) and one attention-based neural network. The main task is to predict the next day’s index price according to the historical data. The dataset consists of the SP500 index, CSI300 index and Nikkei225 index from three different financial markets representing the most developed market, the less developed market and the developing market respectively. Seven variables are chosen as the inputs containing the daily trading data, technical indicators and macroeconomic variables. The results show that the attention-based model has the best performance among the alternative models. Furthermore, all the introduced models have better accuracy in the developed financial market than developing ones.
Gold Nanoparticles Using Ecklonia stolonifera Protect Human Dermal Fibroblasts from UVA-Induced Senescence through Inhibiting MMP-1 and MMP-3
Authors: Jun Eun-Sook , Kim Yeong Jin , Kim Hyung-Hoi , Park Sun Young
Published: August 2020

The effect of gold nanoparticles (GNPs) synthesized in marine algae has been described in the context of skin, where they have shown potential benefit. Ecklonia stolonifera (ES) is a brown algae that belongs to the Laminariaceae family, and is widely used as a component of food and medicine due to its biological activities. However, the role of GNPs underlying cellular senescence in the protection of Ecklonia stolonifera gold nanoparticles (ES-GNPs) against UVA irradiation is less well known. Here, we investigate the antisenescence effect of ES-GNPs and the underlying mechanism in UVA-irradiated human dermal fibroblasts (HDFs). The DPPH and ABTS radical scavenging activity of ES extracts was analyzed. These analyses showed that ES extract has potent antioxidant properties. The facile and optimum synthesis of ES-GNPs was established using UV-vis spectra. The surface morphology and crystallinity of ES-GNPs were demonstrated using high resolution transmission electron microscopy (HR-TEM), energy dispersive spectroscopy (EDS), X-ray diffraction (XRD), and Fourier-transform infrared spectroscopy (FT-IR). ES-GNPs presented excellent photocatalytic activity, as shown by the photo-degradation of methylene blue and rhodamine B. A cellular senescence model was established by irradiating HDFs with UVA. UVA-irradiated HDFs exhibited increased expression of senescence-associated β-galactosidase (SA-β-galactosidase). However, pretreatment with ES-GNPs resulted in reduced SA-β-galactosidase activity in UVA-irradiated HDFs. Intracellular ROS levels and G1 arrest in UVA-irradiated HDFs were checked against the background of ES-GNP treatment to investigate the antisenescence effects of ES-GNPs. The results showed that ES-GNPs significantly inhibit UVA-induced ROS levels and G1 arrest. Importantly, ES-GNPs significantly downregulated the transcription and translation of MMP (matrix metalloproteinases)-1/-3, which regulate cellular senescence in UVA-irradiated HDFs. These findings indicate that our optimal ES-GNPs exerted an antisenescence effect on UVA-irradiated HDFs by inhibiting MMP-1/-3 expression. Collectively, we posit that ES-GNPs may potentially be used to treat photoaging of the skin.
A Fraction of Recommended Practices: Implementation of the FIFA 11+ in NCAA Soccer Programs
Authors: Judge Lawrence W. , Petersen Jeffrey C. , Hoover Donald L. , Craig Bruce W. , Nordmann Nick , Schoeff Makenzie A. , Fox Brian D. , Dickin D. Clark , Bellar David M.
Published: August 2020

Background and Objectives: National Collegiate Athletic Association (NCAA) soccer coaches implement numerous warm-up and flexibility strategies to prepare athletes for training and competition. The Fédération Internationale de Football Association (FIFA) developed the 11+ injury prevention program to reduce non-contact injuries. This study aimed to analyze the level of familiarity with and implementation of the evidence-based FIFA 11+ amongst NCAA Division I (DI) and Division III (DIII) men’s and women’s soccer coaches. Materials and Methods: NCAA soccer coaches in the United States received an Institutional Review Board—approved survey hyperlink. A total of 240 coaches completed the survey. The respondents represented 47.5% men’s and 52.5% women’s teams distributed within DI and DIII programs. Descriptive statistics are reported as frequency counts and mean ± standard deviation where applicable. Pearson’s chi-square tests were performed to assess potential differences with a significance level set at α < 0.05. Results: The results indicated that approximately 62% of the respondents reported being familiar with the FIFA 11+ program. Of those coaches familiar with the program, 15.0% reported full implementation, 57.5% reported partial implementation, and 27.5% reported no implementation. Chi-square analyses revealed significant differences in FIFA 11+ implementation based upon division level (χ2 = 4.56, p = 0.033) and coaching certification levels (χ2 = 13.11, p = 0.011). Conclusions: This study indicates that there is a gap between FIFA 11+ knowledge and actual implementation. To reduce the risk of non-contact injury, there is a need to educate coaches and athletic trainers on the purpose of the FIFA 11+ program and how to perform the exercises correctly.
Microstructure and Mechanical Properties Evolution during Solution and Ageing Treatment for a Hot Deformed, above β-transus, Ti-6246 Alloy
Authors: Alluaibi Mohammed Hayder Ismail , Cojocaru Elisabeta Mirela , Rusea Adrian , Șerban Nicolae , Coman George , Cojocaru Vasile Danut
Published: August 2020

The present study investigates the influence of hot-deformation, above β-transus and different thermal treatments on the microstructural and mechanical behaviour of a commercially available Ti-6246 titanium-based alloy, by SEM (scanning electron microscopy), tensile and microhardness testing techniques. The as-received Ti-6246 alloy was hot-deformed—HR by rolling, at 1000 °C, with a total thickness reduction (total deformation degree) of 65%, in 4 rolling passes. After HR, different thermal (solution—ST and ageing—A) treatments were applied in order to induce changes in the alloy’s microstructure and mechanical behaviour. The applied solution treatments (ST) were performed at temperatures below and above β-transus (α → β transition temperature; approx. 935 °C), to 800 °C, 900 °C and 1000 °C respectively, while ageing treatment at a fixed temperature of 600 °C. The STs duration was fixed at 27 min while A duration at 6 h. Microstructural characteristics of all thermomechanical (TM) processed samples and obtained mechanical properties were analysed and correlated with the TM processing conditions. The microstructure analysis shows that the applied TM processing route influences the morphology of the alloy’s constituent phases. The initial AR microstructure shows typical Widmanstätten/basket-weave-type grains which, after HR, are heavily deformed along the rolling direction. The STs induced the regeneration of α-Ti and β-Ti phases, as thin alternate lamellae/plate-like structures, showing preferred spatial orientation. Also, the STs induced the formation of α′-Ti/α″-Ti martensite phases within parent α-Ti/β-Ti phases. The ageing treatment (A) induces reversion of α′-Ti/α″-Ti martensite phases in parent α-Ti/β-Ti phases. Mechanical behaviour showed that both strength and ductility properties are influenced, also, by applied TM processing route, optimum properties being obtained for a ST temperature of 900 °C followed by ageing (ST2 + A state), when both strength and ductility properties are at their maximum (σUTS = 1279 ± 15 MPa, σ0.2 = 1161 ± 14 MPa, εf = 10.1 ± 1.3%).
A Genome-Scale Insight into the Effect of Shear Stress During the Fed-Batch Production of Clavulanic Acid by Streptomyces Clavuligerus
Authors: Gómez-Ríos David , López-Agudelo Victor A. , Ramírez-Malule Howard , Neubauer Peter , Junne Stefan , Ochoa Silvia , Ríos-Estepa Rigoberto
Published: August 2020

Streptomyces clavuligerus is a filamentous Gram-positive bacterial producer of the β-lactamase inhibitor clavulanic acid. Antibiotics biosynthesis in the Streptomyces genus is usually triggered by nutritional and environmental perturbations. In this work, a new genome scale metabolic network of Streptomyces clavuligerus was reconstructed and used to study the experimentally observed effect of oxygen and phosphate concentrations on clavulanic acid biosynthesis under high and low shear stress. A flux balance analysis based on experimental evidence revealed that clavulanic acid biosynthetic reaction fluxes are favored in conditions of phosphate limitation, and this is correlated with enhanced activity of central and amino acid metabolism, as well as with enhanced oxygen uptake. In silico and experimental results show a possible slowing down of tricarboxylic acid (TCA) due to reduced oxygen availability in low shear stress conditions. In contrast, high shear stress conditions are connected with high intracellular oxygen availability favoring TCA activity, precursors availability and clavulanic acid (CA) production.
Assessing the Combined Effect of Water Temperature and Complex Water Matrices on Xanthate Adsorption Using Multiple Linear Regression
Authors: Mhonde Ngoni , Schreithofer Nora , Corin Kirsten , Mäkelä Mikko
Published: August 2020

The combined effect of dissolved ions and water temperature on the adsorption of a xanthate collector on chalcopyrite and pentlandite was investigated using multiple linear regression. Cationic species improved the adsorption of the collector on sulphide minerals through xanthate adsorption activation. Thiosulphate ions generally had a negative effect on collector adsorption, and the interaction of thiosulphate ions and cations effectively reduced collector adsorption on the sulphide minerals. With regards to temperature variation caused by seasonal variation, this study suggests that temperature can influence the adsorption of collectors in the flotation process and this should be approached on a case by case basis as it seems to differ with the type of mineral under investigation. These fundamental results prompt a discussion on how complex water matrices can affect interactions of reagents and sulphide minerals at the solid–liquid interface and the possible effect on flotation performance.
Preparation of Robust Hydrogen Evolution Reaction Electrocatalyst WC/C by Molten Salt
Authors: Yan Pengpeng , Wu Yuchen , Wei Xiaofeng , Zhu Xuewei , Su Wei
Published: August 2020

Tungsten carbide (WC) is an alternative to the costly and resource-constrained Pt-based catalysts for hydrogen evolution reaction (HER). In this work, a one-step facile and easily scalable approach is reported, to synthesize ultrafine WC by molten salt. Benefiting from the ideal synergistic catalytic effect between the highly active WC nanoparticles and the conductive graphitic carbon, and strong charge transfer ability, the unique WC/C hybrids demonstrated excellent HER performance in both acid and alkaline medias with overpotentials of 112 and 122 mV, at a current density of 10 mA cm−2 and Tafel slopes of 54.4 and 68.8 mV dec−1, in acid and alkaline media, and remarkable stability. With the simplicity and low-cost of the synthetic approach, the strategy presented here can be extendable to the preparation of other transition metal-based/carbon hybrids for versatile applications.
Comparing Methods for Calculating Nano Crystal Size of Natural Hydroxyapatite Using X-Ray Diffraction
Authors: Rabiei Marzieh , Palevicius Arvydas , Monshi Ahmad , Nasiri Sohrab , Vilkauskas Andrius , Janusas Giedrius
Published: August 2020

We report on a comparison of methods based on XRD patterns for calculating crystal size. In this case, XRD peaks were extracted from hydroxyapatite obtained from cow, pig, and chicken bones. Hydroxyapatite was synthesized through the thermal treatment of natural bones at 950 °C. XRD patterns were selected by adjustment of X-Pert software for each method and for calculating the size of the crystals. Methods consisted of Scherrer (three models), Monshi–Scherrer, three models of Williamson–Hall (namely the Uniform Deformation Model (UDM), the Uniform Stress Deformation Model (USDM), and the Uniform Deformation Energy Density Model (UDEDM)), Halder–Wanger (H-W), and the Size Strain Plot Method (SSP). These methods have been used and compared together. The sizes of crystallites obtained by the XRD patterns in each method for hydroxyapatite from cow, pig, and chicken were 1371, 457, and 196 nm in the Scherrer method when considering all of the available peaks together (straight line model). A new model (straight line passing the origin) gave 60, 60, and 53 nm, which shows much improvement. The average model gave 56, 58, and 52 nm, for each of the three approaches, respectively, for cow, pig, and chicken. The Monshi–Scherrer method gave 60, 60, and 57 nm. Values of 56, 62, and 65 nm were given by the UDM method. The values calculated by the USDM method were 60, 62, and 62 nm. The values of 62, 62, and 65 nm were given by the UDEDM method for cow, pig, and chicken, respectively. Furthermore, the crystal size value was 4 nm for all samples in the H-W method. Values were also calculated as 43, 62, and 57 nm in the SSP method for cow, pig, and chicken tandemly. According to the comparison of values in each method, the Scherrer method (straight line model) for considering all peaks led to unreasonable values. Nevertheless, other values were in the acceptable range, similar to the reported values in the literature. Experimental analyses, such as specific surface area by gas adsorption (Brunauer–Emmett–Teller (BET)) and Transmission Electron Microscopy (TEM), were utilized. In the final comparison, parameters of accuracy, ease of calculations, having a check point for the researcher, and difference between the obtained values and experimental analysis by BET and TEM were considered. The Monshi–Scherrer method provided ease of calculation and a decrease in errors by applying least squares to the linear plot. There is a check point for this line that the slope must not be far from one. Then, the intercept gives the most accurate crystal size. In this study, the setup of values for BET (56, 52, and 49 nm) was also similar to the Monshi–Scherrer method and the use of it in research studies of nanotechnology is advised.
Norovirus Is the Most Frequent Cause of Diarrhea in Hospitalized Patients in Monterrey, Mexico
Authors: Casillas-Vega Néstor , Flores-Rodríguez Fernanda , Sotelo-Coronado Israel , Vera-García Magda Elizabeth , García-Heredia Aldo , Rivas-Estilla Ana Ma. , Lozano-Sepúlveda Sonia A. , García Santos , Flores-Arechiga Amador , Heredia Norma
Published: August 2020

Little information is available regarding the pathogens that cause diarrhea in hospitalized patients who also have various clinical problems. The purpose of this study was to determine the presence of pathogens in fecal samples of hospitalized patients all suffering diarrhea in addition to other problems in Mexico. Diarrheic stools from 240 patients were obtained in a third-level hospital in Monterrey, Mexico. PCR was used for the detection of Salmonella spp., Shigella spp., Campylobacter spp., Yersinia spp., Aeromonas spp., Clostridioides difficile, and norovirus GI and GII. The presence of trophozoites, cysts of protozoa, eggs, and/or helminth larvae was determined by microscopic observation. Of the 240 patients analyzed, 40.4% presented at least one of the pathogens analyzed. Norovirus was the pathogen most frequently found (28.6%), followed by bacteria (11.7%), and parasites (8.3%). The majority of co-infections were parasites + norovirus, and bacteria + norovirus. Norovirus was detected mainly in children aged 0 to 10 years (9/15, 60%). Patients aged 0–20 years did not present co-infections. Entamoeba coli and Entamoeba histolytica were the most common parasites, (8/240), and Salmonella was the most prevalent bacteria (10/240). This information can help design specific strategies useful for hospitalized people with a compromised status.