bluuebunny/crossref_metadata_2025 huggingface dataset:
Policy attention drives PM2.5 concentration reduction in China: evidence from spatial econometric analysis
Authors: Yang Shu-Hao , Li Bo , Chu Cheng-Jun , Rong Bing , Wang Ming-Xu
Published: October 2023

This article examines the relationship between government policy attention and air quality improvement in 285 Chinese cities between 2014 and 2019. We use the frequency of environmental-related vocabulary in annual government reports as an indicator of policy attention and employ a spatial panel model to quantify the impacts of policy attention on PM2.5 concentration reduction. This study attempts to explore the key driving factor from the perspective of government’s motivation and behavior and reveal the effectiveness difference by identifying heterogeneity derived from region endowment discrepancy. Our results demonstrate that environmental policy attention has a significant negative effect on PM2.5 concentration, both directly and indirectly. This study testifies the mechanism behind the effect that policy attention promotes green innovation by affecting relevant enterprises’ expectations and formulating incentive policies, which partially contributes to pollution control and PM2.5 concentration reduction.
Prevalence of Pathergy After Surgical Procedures in Patients with History of Pyoderma
Authors: Borda Luis J. , Saal Ryan C. , Encarnacion Iain Noel M. , Smith Robert J.
Published: October 2023

Background: Pathergy refers to the tendency of a cutaneous disease, such as pyoderma gangrenosum (PG), to arise or flare at sites of physical trauma. The rate of pathergy following routine surgical procedures among patients with known PG is not well described.
Objective: To determine the clinical variables that predict pathergy following surgical procedures in patients with a known history of PG.
Methods: A single-center retrospective chart review was performed from 2015-2021 to identify patients with history of pyoderma gangrenosum, in order to collect: demographics, history of undergoing a surgical procedure, surgical anatomical location, type of PG lesion, comorbidities, and treatments.
Results: 40 patients with a history of PG were identified, 29 (72.5%) were female, and 20 (50%) were white. Of the 12 (30%) patients who underwent surgery, such as orthopedic surgery, mastectomy and other procedures, 6 (50%) developed pathergy as a post-surgical complication. Patients with history of PG developed more PG after surgery (P=0.0002). There was no association between ongoing PG-specific treatment at moment of surgery and development of pathergy (P=0.06).
Conclusions: PG patients are susceptible to pathergy following procedural interventions; thus, improved understanding of specific factors associated with a higher likelihood of pathergy after surgical procedures in PG may help improve identification of these patients in an outpatient dermatologic setting.
‘Context really matters’ - The role of energy system modelling in policymaking in low- and middle-income countries
Authors: Fuchs Janina Luisa , Tesfamichael Meron , Clube Rebecca , Tomei Julia
Published: October 2023

Energy system models are widely used to explore, analyse and plan energy futures and sustainable transitions. These models, often developed in high-income countries, have more recently been applied in low- and middle-Income countries (LMICs). As a result, the role that modelling plays in informing decisions in such contexts lacks adequate exploration. Drawing on 35 qualitative interviews with energy system modellers and policymakers, this research examines the experiences of developing and using energy system models that support decision-making in LMICs. It shows that many conventional modelling approaches do not account for the political economy influences and developmental challenges specific to LMICs, with implications on modelling processes and outcomes. The interviews highlighted the need to understand the roles played by diverse stakeholders in shaping modelling processes as well as their communication, interpretation and use of energy models. This indicates that, especially in modelling projects which bring in external modellers, a good understanding of the country context is essential in order to design appropriate model scenarios and interpret them in the wider relevant context for policymaking. Finally, more in-country capacity is needed to foster local ownership of modelling projects.
The effect of nitric oxide donation on the severity of mitochondrial disfunction to the renal tissue in cardiopulmonary bypass simulation: an experimental study
Authors: Tyo Mark A. , Kamenshchikov N. O. , Podoksenov Yu. K. , Mukhomedzyanov A. V. , Maslov L. N. , Kozlov B. N.
Published: October 2023

INTRODUCTION: Acute kidney injury is one of the common complications in cardiosurgical operations with cardiopulmonary bypass (CPB). A number of studies have shown that donation of exogenous nitric oxide (NO) reduces episodes of аcute kidney injury. However, subcellular mechanisms of realization the nephroprotective properties of NO remain unknown. OBJECTIVE: To study the safety of the technology of plasma-chemical synthesis of nitric oxide and to evaluate the effect of the delivery resulting nitric oxide on mitochondrial damage to the renal tissue in the simulation of cardiopulmonary bypass. MATERIALS AND METHODS: Experiment included 12 rams of the Altai breed. Animals were divided into 2 groups: 6 animals were modeled CPB; 6 animals were simulated CPB with NO delivery. Mitochondrial damage was assessed by calcium-binding capacity and transmembrane potential of mitochondria 1 h after weaning from the CPB. The safety of the NO delivery according to the proposed method was assessed by the concentration of nitrogen dioxide on inspiration, the level of methemoglobin. The efficiency of NO delivery according to the proposed method was assessed by the level of stable NO metabolites: endogenous nitrite, nitrate and total concentration of NO metabolites. RESULTS: In the group of animals with NO delivery the average level of transmembrane potential of mitochondria was (171.66 ± 20.41 vs 126.66 ± 18.61; p = 0.00256) and calcium-binding capacity of mitochondria was (1466.66 ± 216.02 vs 866.66 ± 216.02; p = 0.000712) of renal parenchyma. Methemoglobin levels above the recommended thresholds in clinical practice were not recorded in the CPB+NO group. The values of total concentration of NO metabolites and nitrate in the CPB+NO group compared to the CPB group are statistically significantly higher, p = 0.00006; p = 0.0035, respectively. CONCLUSIONS: Plasma-chemical synthesis of nitric oxide is a safe technology, and the use of the resulting nitric oxide in cardiopulmonary bypass leads to a decrease in the severity of mitochondrial dysfunction in the kidney parenchyma.
Septic shock in adults: guidelines of the All-Russian public organization “Federation of Anesthesiologists and Reanimatologists”
Authors: Kirov M. Yu. , Kuzkov V. V. , Protsenko D. N. , Shchegolev A. V. , Babaev M. A. , Belotserkovskiy B. Z. , Bykov A. O. , Gritsan A. I. , Kulabukhov V. V. , Kulikov A. V. , Kupreichik V. L. , Lakhin R. E. , Lebedinskii K. M. , Rey S. I. , Rudnov V. A. , Smetkin Alexey A. , Surkov M. V. , Shifman E. M. , Shlyapnikov S. A. , Yarustovsky M. B. , Zabolotskikh I. B.
Published: October 2023

The paper represents the clinical guidelines for septic shock in adults, approved by the All-Russian public organization “Federation of anesthesiologists and reanimatologists” in 2023. Septic shock is a widespread condition with a high mortality rate. The recommendations cover the issues of etiology, pathogenesis, clinical signs and symptoms, methods of laboratory and instrumental diagnosis of septic shock. The clinical guidelines present initial therapy for septic shock, including approaches to vasopressor and inotropic therapy, recommendations for choosing antibacterial drugs, fluid and adjuvant therapy. The issues of surgical treatment of the infection are discussed. The article contains the criteria for the quality of medical care for the adult patients with septic shock and algorithms for the decision making in the diagnosis and intensive care of patients with septic shock.
Investigation of Six (06) Cases of AFP Notified from Week 01 to 17 in the Health District of Kolondièba in Mali in 2023
Authors: Kafflouman Kouamé Stanislas
Published: October 2023

Poliomyelitis is an infectious disease caused by the poliovirus and largely affects children under the age of 05. Our descriptive study concerned the analysis of suspected cases of poliomyelitis notified from week 01 to 17 in the health district of Kolondièba in 2023. During this period six (06) cases of AFP were notified by Community Health Centers (CHC) from Diaka (02 cases), Kolosso (01 case), Central (02 cases) and Fakola (01 case) case imported from the Ivory Coast in search of care. Their age range was 0-4 years and presented paralysis of the lower limbs for some and upper for others. Vaccination coverage with oral polio vaccine in the first quarter in Diaka and Kolosso was 95%, on the other hand, Central and Kolosso had a rate <95%. The female gender accounted for 66.67% of cases with a sex ratio of 0.6. The attack rate was 8.91 cases per 100,000 inhabitants. Only three of the six (06) cases received at least three doses of vaccine. The risk factors were the uncontrolled migratory flow and the inaccessibility of health centers. The assessment of the living environment did not show any environmental risk factors. The survey made it possible to build the capacity of service providers on the surveillance of notifiable diseases, raise public awareness of risk factors, the declaration of children under 15 with paralysis regardless of the cause at the health center. and compliance with the vaccination schedule. Keywords : AFP, Mali, Poliomyelitis, investigation, vaccination.
Prevalence and Risk Factors Associated with Maternal Near Miss Events in the Upper East Region of Ghana
Authors: Ofosu Winfred Komla
Published: October 2023

A maternal near miss (MNM) event is a severe life-threatening maternal morbidity that reflects quality of obstetric care. It is considered a proxy of maternal mortality and predictor of quality obstetric care. The major underlying causes of MNM are hypertensive disorders, obstetric hemorrhage, sepsis and abortion complications. MNM is a more frequent event than maternal mortality and share several features together. Inquiries intodeficiencies andcritical assessment of health care quality, identify health system deficiencies, and help develop robust strategies for maternal care. We conducted a cross-sectional descriptive study to determine the prevalence and underlying causes of MNM. The study respondents were women aged 15 - 49 years with pregnancy experience in 2020 who had health facility care. Primary and secondary data were collected at households and health facilities respectively using electronic platform, KoBoCollect. STATA version 15.0 was used to analyze the data. The prevalence of MNM was 11.30%. The main underlying causes were complications of caesarean section, hypertensive disorders, anemia, obstructed labor, and antepartum hemorrhage. The main signal functions of emergency obstetric and newborn care (EmONC) employed to avert death were parenteral antibiotics, blood transfusion, caesarean section, and magnesium sulphate. The prevalence of MNM in the Upper East region was high. The region can reduce severe maternal morbidity and mortality by strengthening health systems, improving access to high-quality obstetric care and training healthcare providers to prevent and treat the major underlying causes of MNM identified in this study. Keywords: Ghana, MNM, Mortality, Prevalence, Antepartum, Hemorrhage, EmONC.
How the Special Needs Education Intervention Can Address the Learning Disabilities and Associated Psychosocial Problems in South Sudan, A Case of Jamjang Camps
Authors: Achiek Abraham Ngor
Published: October 2023

The study on the Learning disabilities and associated psychosocial problems among children started in October 2022 in South Sudan. The deepening loneliness and vulnerability of the children with the learning disabilities and the associated psychosocial problems among children resulting from the conflict in Sudan, which tore the family union, social fabric in the community structures, and pushed the families into the refugee camps where they have limited access to livelihood that everything to nurture the children is at the appalling stage. The study aimed at ascertaining the presence of learning disabilities and associated psychosocial problems among children in Jamjang Refugee camps. The study used qualitative, quantitative, and ethnographical/anthropological methods to have in-depth comprehension of the facts surrounding the phenomenon. The tools used in the design include questionnaire, interview, and observation. The pilot study conducted in April 2023 ascertained the presence of learning disabilities among refugee children. This consist of dyslexia, dysgraphia, and dyscalculia elucidated as deficiency to write, spell, comprehend, articulate point in written, grammatical errors, poor paragraph organization, spelling errors, and poor arithmetic calculation. The study also confirmed the presence of the associated psychosocial problems which include low self-esteem, discrimination, bullying, stigmatization, neglect, sexual abuse, and rejection. Finally, the finding confirmed the learning disabilities cause the associated psychosocial problems among the children. Whereas the special needs education with the application of multisensory approaches, different recreational games, and Skinner’s Operant conditioning theory, Cognitive Behavioral theory of Bandura are indispensably crucial in reducing the adverse effects of the phenomenon. Keywords: Auditory, Anxiety, Dyslexia, Dyscalculia, dysgraphia, Depressive disorder, PTSD, visual.
100 Yıllık Türkiye Ekonomisi: Enflasyon ve Dış Ticaret Dengesi’nin Yapısal Değişim Analizi
Authors: BURGAÇ ÇİL Almıla , FİSUNOĞLU Hüseyin Mahir
Published: October 2023

Bu çalışma, bir asırlık Türkiye ekonomisinde enflasyon oranı ve dış ticaret dengesindeki yapısal değişimleri dikkate alarak incelemeyi ve ekonomi politikalarındaki rejim değişikliklerinin etkili olup olmadığını ortaya koymayı amaçlamıştır. Çalışmada 100 yıllık en önemli iki sorun olan enflasyon ve dış ticaret dengesinin nedenleri ve çözüm yöntemleri yerine bir asırlık süreçteki yapısal değişimlerin tespiti üzerinde yoğunlaşılmıştır. Bu amaçla, 1923-2023 yılları için enflasyon oranı ve dış ticaret dengesi (ihracatın ithalatı karşılama oranı) serilerinde meydana gelen trend ve düzeyde değişimin varlığı ve tarihleri Bai ve Perron (2003) çoklu yapısal kırılma modeli ve Hodrick-Prescott (HP) trend çerçevesinde analiz edilmiştir. Çalışmanın bulguları temel olarak kısa ve orta vadede değişkenlerin döngülerinin tersine dönmesinin oldukça uzun sürmekte olduğunu göstermektedir. Cumhuriyet’in kuruluşundan bugüne kadar enflasyon tarihinde enflasyon trendinin negatif olduğu dönemler oldukça az iken genellikle enflasyon trendinin pozitif eğilimde olduğu görülmektedir. Hem HP uzun dönem trend analizi hem de içsel olarak belirlenen yapısal değişim dönemlerine ilişkin kanıtlar enflasyon döngüsünün kalıcı olduğunu ve eğiliminin 1970’li yıllardan sonra artmaya başladığını, 2001 krizine kadar yüksek kaldığını ortaya koymuştur. Diğer taraftan ihracatın ithalatı karşılama oranına yönelik sonuçlar ise 1980 sonrasında ihracatın ithalatı karşılama oranında dikkate değer bir değişimin olmadığı görülmektedir. Özellikle 1980 ihracata yönelik büyüme stratejisi sonrası negatif trend ve düzeyde bir kırılma olduğunu gösterse de çok belirgin bir iyileşmenin gerçekleşmediğine yönelik bulgular ortaya koymaktadır.
Cumhuriyetin 100. Yılında Türk Dış Politikasına Dair Bir Değerlendirme: Güvenlik Arayışından Güvenlik Sağlayan Küresel Oyunculuğa
Authors: BAĞCI Hüseyin , DEMİREL Murat
Published: October 2023

Geçen yüz yıl zarfında Türkiye, uluslararası sistemdeki aktörlerle tarihsel ilişkileri göz önüne alındığında kendi ulusal çıkarları doğrultusunda pragmatik etkileşim ağları örebilen, uluslararası sistemin bağlamsal baskıları altında değişim getiren hamleler yapabilen, ilgili aktörlerle her konuda anlaşamasa da ilişki ağlarını iş birliğine yönelik şekilde sürdürme becerisine sahip, etkileşimlerini jeopolitik konumunun bir gereği olarak dengede tutabilen bir aktör olarak gözükmektedir. Türk dış politikasının 100 yıllık seyrini neden-sonuç ilişkileriyle incelemenin güçlüğüne rağmen bu makale tarihsel süreci dikkate alarak Türk dış politikasının 2023 yılındaki portresini betimleyici bir alt yapı ile yeni bir çerçevede yorumlamaktadır. Cumhuriyet’in 100. yılında, dünyada jeopolitik kırılmaların yaşandığı bir dönemde, küresel bir oyuncu ve güvenlik sağlayan bir aktör olan Türkiye’nin bu kırılmalardan en fazla etkilenen ve etkilenecek olan ülkelerden biri olduğu söylenebilir. Bu bağlam içerisinde, Türk dış politikasına dair dört temel özellikten söz edilebileceğini savunan makale, bu iddiayı ilgili veri, gözlem ve örneklerle açıklamaya çalışmıştır. Bu argüman, Türkiye’nin diplomatik kapasite ve yeteneklerindeki gelişimin, uluslararası düzen içerisinde Türk dış politikasını etki sahasını da genişleterek daha etkili bir hâle getirme yöneliminde olduğu; Türkiye’nin, güç merkezleri olarak ifade edilebilecek Amerika Birleşik Devletleri (ABD), Avrupa Birliği (AB), Çin ve Rusya ile etkileşimde bulunma ve çıkarlarını denge politikasıyla sağlama eğiliminde olduğu; Türkiye’nin uluslararası sistem içerisinde güvenlik sağlayan bir aktör konumuna geldiği ve Türk dış politikasının son 100 yıllık tecrübesinin, Türkiye’yi uluslararası sistemde daha dirençli bir aktöre dönüştürebilecek unsurlar içerdiği şeklindedir.
Cumhuriyetimizin Yüzüncü Yılında Asker-Sivil İlişkilerine Yeniden Bakmak: Sivillerin Darbe Destekleri ve Cunta Girişimleri
Authors: ULUS Özgür Mutlu
Published: October 2023

Cumhuriyet, siyasi iktidarın halk ve temsilcileri tarafından paylaşıldığı, egemenliğin kaynağının millet olarak kabul edildiği bir rejim türüdür. Cumhuriyet’in kuruluşundan 100 yılına dek geçen sürede, çok partili demokratik sisteme geçildikten sonra millî egemenliğe yönelik en büyük tehdit 27 Mayıs 1960 askerî darbesinden bu yana periyodik olarak gerçekleşen askerî darbeler, darbe girişimleri ve ordunun siyasete müdahaleleri olmuştur. Bu çalışma, 1960'taki ilk askerî darbeden günümüze kadar askerî darbelere verilen çeşitli sivil destek biçimlerini incelemektedir. Sivil destek, askerî vesayetin devam etmesi için çok önemli ancak sıklıkla ihmal edilen, akademik olarak az çalışılmış unsurdur. Bu çalışma, asker-sivil ilişkilerindeki ikilik ve çatışmaya odaklanmak yerine, bu iki alan arasındaki ilişkileri vurgulamayı amaçlamaktadır. Darbelere özellikle elit desteği askerî vesayetin sürebilmesinin unsurlarından biridir. Diğer yandan sivil destek askerî yönetimlerin görece kısa sürmesine neden olmuştur. Bu çalışma sivil destekleri belgelerken bunların nasıl meşrulaştırıldığını irdeleyecektir. Ordunun özerlik kazanarak siyasi bir aktör olarak ortaya çıkması ile sivillerin hangi tarihsel-toplumsal koşullar içinde cuntalara neden, nasıl dahil oldukları incelenecektir. Türkiye'de sivil desteğin temel nedenlerinden biri, ordunun Cumhuriyet'in kuruluşunda yer almasının bir sonucu olarak "modernleştirici" hatta "özgürlükçü" bir öze sahip olduğu inancı ve algısıdır. Ordu siyasete karıştığında bunu "Kemalizm", “Cumhuriyet değerlerinin restorasyonu” “Atatürkçülüğün restorasyonu” ile açıklayarak toplumsal destek ve meşruiyet sağlamıştır. Atatürk'ün en önemli siyasi doktrinlerinden biri askerî ve siyasi görevlerin birbirinden ayrılmasıyken "Kemalizm" ironik bir şekilde darbelere meşruiyet sağlamanın ve sivil desteğin kilit unsurlarından biri olmuştur.
Paisajes agrícolas como recurso turístico y oportunidad para el desarrollo local. El caso del Cinturón Verde de Mendoza (Argentina)
Authors: Suden Clarisa , Esteves Matías
Published: October 2023

La pandemia COVID-19 puso en evidencia la necesidad de replantear la oferta turística interna. Frente a la imposibilidad o dificultades de viajes a destinos icónicos de nuestro país o incluso del extranjero, la “industria” turística se orientó a repensar nuevos atractivos centrados en la oferta interna. De este modo, paisajes que habían pasado inadvertidos por gran parte de la población, comenzaron a presentarse como potenciales opciones para el disfrute. En este sentido, la provincia de Mendoza se presenta como un territorio rico y diverso, con gran potencial si sus disímiles/heterogéneos paisajes fuesen puestos en valor turístico, promocionados y adecuadamente gestionados. Mediante un esquema metodológico cuali-cuantitativo, el objetivo es indagar en el paisaje del Cinturón Verde de Mendoza (CVM) y sus componentes en clave turística, que permita dar cuenta de posibles actividades recreativas y culturales asociadas a su territorio y como estrategia para alcanzar el desarrollo local. En este sentido, se analiza la realidad histórica del cinturón verde de Mendoza y se proponen posibles rutas turísticas que permitirían articular elementos naturales y construidos con diferentes características y que componen los variados paisajes rurales que se valorizarían como recurso turístico.
Argumentação multimodal a partir da articulação de semioses no gênero advergame
Authors: Soares Edilson de Souza , Azevedo Isabel Cristina Michelan de
Published: October 2023

A Base Nacional Comum Curricular (BRASIL, 2018), cuja versão final foi publicada em 2018, reconhece as Tecnologias Digitais da Informação e Comunicação como uma realidade impactante nos processos de ensino e aprendizagem, como aponta a quinta competência geral que prevê a compreensão, o uso de tecnologias digitais de informação e comunicação de forma crítica, significativa, reflexiva e ética nas práticas de linguagem, incluindo as que acontecem na escola. A BNCC também reconhece, na competência geral número sete, que a argumentação é um importante objeto de ensino e aprendizagem, visto que promove a formulação, negociação e defesa de ideias, pontos de vista, o que favorece a tomada de decisão em variados espaços sociais. Entende-se que, por isso, os novos gêneros multimodais e argumentativos em circulação são citados diretamente na Base (como podcasts, social advertising, advergames etc.), porém faltam estudos voltados à descrição e análise linguística de seus aspectos constitutivos. Essa carência nos instigou a propor o desenvolvimento de uma pesquisa qualitativa, em nível de doutorado, voltada à caracterização do gênero digital multimodal argumentativo advergame. Pretende-se analisar e descrever alguns dos processos semióticos e linguísticos no campo da argumentação multimodal, partindo da observação desse gênero em uso, utilizando as bases teóricas da argumentação prática (GONÇALVES-SEGUNDO, 2020), da Retórica da Argumentação Visual (KJELDSEN, 2015, 2018) e da Gramática do Design Visual (KRESS; VAN LEEUWEN, 2006). O recorte feito para este artigo traz algumas análises iniciais feitas a partir do advergame Cooking Mama, The Unauthorized PETA Edition: Mama Kills Animals. Assim, espera-se contribuir com a compreensão linguística dos aspectos constitutivos desse gênero e com a geração de subsídios para compor práticas pedagógicas alinhadas aos desafios contemporâneos.
Práticas de letramento no Laboratório de Leitura e Produção Textual: gênero científicos, oralidade e tecnologias digitais
Authors: Freire de Sousa Ana Beatriz , Lopes Batista Júnior José Ribamar
Published: October 2023

O Laboratório de Leitura e Produção Textual (LPT/CNPq) desenvolve atividade de ensino, pesquisa e extensão com estudantes do Ensino Médio Técnico e Tecnológico e Graduação, com o objetivo de tornar essas/es jovens protagonistas dentro da sociedade, alcançando a sua emancipação e local de fala. O presente trabalho visa apresentar cinco projetos de letramento realizados no Ensino Médio do Colégio Técnico de Floriano e o curso de extensão “Leitura e escrita para jovens: introdução aos gêneros científicos”, pautados nos letramentos, dentro das competências e habilidades apontadas na Base Nacional Comum Curricular (BNCC), aproximando assim, as/os jovens da cultura interdisciplinar, leitura e escrita de gêneros discursivos incluindo os científicos, a fim de amenizar as dificuldades encontradas dentro de sala de aula em relação aos diferentes textos. Dessa forma, o LPT promove ações e atividades educacionais e sociais, incentivando as/os estudantes da educação básica a se tornarem sujeitos ativos na sociedade em que vivem, estimulando o crescimento pessoal, acadêmico e profissional, superando dificuldades muitas vezes encontradas por falta de oportunidades.
Co-mutation of TP53 and TTN is Correlated with the Efficacy of Immunotherapy in Lung Squamous Cell Carcinoma
Authors: Ying Kaijun , Zou Li , Wang Daquan , Wang Rao , Qian Jun
Published: October 2023

Background:

Immunotherapy has been a promising treatment in advanced lung cancer.
However, only a few patients could benefit from it. Herein, we aimed to explore mutationrelated
predictive biomarkers in lung squamous cell carcinoma (LUSC), which could help develop
clinical immunotherapy strategies and screen beneficial populations.

Methods:

Co-occurrence and mutually exclusive analysis was conducted on the TCGA-LUSC
cohort. Correlations between the gene mutation status and tumor mutation burden (TMB) levels,
and neo-antigen levels were analyzed by Wilcoxon test. Kaplan-Meier method was employed to
analyze the progression-free survival (PFS) of lung cancer patients with immunotherapy. Gene
set enrichment analysis (GSEA) was used to investigate the functional changes affected by
TP53mut/TTNmut. The immune cell infiltration landscape in co-mutation subgroups was analyzed
using CIBERSORT.

Results:

1) TP53, TTN, CSMD3, MUC16, RYR2, LRP1B, USH2A, SYNE1, ZFHX4,
FAM135B, KMT2D, and NAV3 were frequently mutated in LUSC patients. 2) TMB levels in
highly mutated groups were higher than that in wild type groups. 3) There were higher neoantigen
levels in mutation group compared to the wild-type group, and LUSC patients in mutation
group had longer PFS. 4) TP53mut/TTNmut co-mutation group exhibited higher TMB levels
and better response to immunotherapy. 5) A host of immune-related signaling pathways was inhibited
in TP53mut/TTNmut subgroup. 6) There were more T follicular helper cells and NK cells
were in TP53mut/TTNmut subgroup than in the WT subgroup.

Conclusion:

The LUSC patients with TP53 and TTN co-mutation had higher TMB levels and
better response to immunotherapy. The TP53 and TTN co-mutation is a promising novel biomarker
to assist LUSC immunotherapy evaluation.
Personality Traits and Anxiety Disorders of Vietnamese Early Adolescents: The Mediating Role of Social Support and Self-Esteem
Authors: Thuy Nguyen Thi
Published: October 2023

Aims:

This study aims to investigate the relationship between personality traits and anxiety disorder, in which the mediating role of social support and self-esteem is also explored.

Background:

In Vietnam, anxiety disorder is a major challenge affecting adolescents’ social and academic functioning.

Objectives:

Examine whether adolescents’ personality traits are related to their anxiety disorders and whether social support and self-esteem mediate the relationship between personality and anxiety disorders.

Methods:

A sample population of 582 early adolescents at four secondary schools in Vietnam voluntarily participated in the study through the completion of the big-five personality dimension test, the social support scale, self-esteem scale and generalized anxiety disorder questionnaire. The SPSS statistical software was used to conduct descriptive statistics and analyses of Cronbach’s Alpha, Pearson correlations and Regression. The mediation analysis of self – esteem and social support was conducted to determine the relationship between personality traits and anxiety disorder through SPSS PROCESS Macro.

Results:

Results revealed that the neuroticism trait had a positive correlation with anxiety disorders (r = 0.56), while the agreeableness and conscientiousness traits showed negative correlations (r = - 0.08 and r = - 0.15, respectively). The regression indicated that approximately 33.4% of the variance anxiety could be explained by these traits (R2 = 0.334; F = 55.414; p < 0.01). Bootstrapping and Sobel analyses showed that social support and self-esteem mediated the association between neuroticism trait and anxiety disorder (z = 3.00 and z = 5.45, respectively).

Conclusion:

The findings interpreted that Vietnamese educators can reduce symptoms of anxiety for early adolescents with high neuroticism trait by helping them get more social support from others and improve role of self-esteem.
The Influence of Occlusal Adjustment on Long-term Post-treatment Stability of Orthodontic Treatment
Authors: Bonadio Marcos Fernando , Cotrin Paula , Marín Ramirez Cecília Maria , Fialho Tiago , da Silva Moura Wilana , de Oliveira Renata Cristina Gobbi , de Oliveira Ricardo Cesar Gobbi , Valarelli Fabricio Pinelli , Pinzan-Vercelino Célia Regina Maio , Salvatore Freitas Karina Maria
Published: October 2023

Objective:

This study aimed to compare the long-term occlusal stability in patients treated orthodontically with and without occlusal adjustment.

Material and Methods:

This observational study followed the STROBE guidelines. The sample comprised 77 patients with class I malocclusion treated without dental extractions and without signs and symptoms of temporomandibular joint dysfunction (TMD), divided into two groups. Group 1 with occlusal adjustment comprised 37 patients, 16 males and 21 females, with mean initial, final, and post-retention ages of 18.33 (s.d.=3.96), 20.99 (s.d.=3.33), and 25.79 years (s.d.=3.34), respectively. The treatment time was 2.66 years (s.d.=1.57), and the time of post-retention evaluation was 4.80 years (s.d.=1.10). Group 2, without occlusal adjustment involved 40 patients, 21 males and 19 females, with mean initial, final, and post-retention ages of 18.07 (s.d.=3.03), 20.75 (s.d.=3.54), and 25.89 (s.d.=3.73) years, respectively. The treatment time was 2.68 years (s.d.=1.09) and the time of post-retention evaluation was 5.14 years (s.d.=1.36). The PAR and Little irregularity indices were measured in the initial, final, and post-retention dental casts. Intergroup comparison was performed using the independent t-test.

Results:

There was no statistically significant difference observed in the intergroup comparison of the PAR and Little irregularity indexes in all phases and periods evaluated.

Conclusion:

There was no significant difference found in the long-term post-treatment crowding and occlusal relapse between class I patients treated with orthodontic non-extraction with and without occlusal adjustment. The occlusal adjustment did not influence the alignment and occlusal post-retention stability.
Clinical Characteristics of Systemic Sclerosis-associated Myopathy Patients Comparing Different Subgroups of Inflammatory Myopathies
Authors: Suwansirikul Songkiet , Intum Jirapath , Tejamai Chontichaporn , Wangkaew Suparaporn
Published: October 2023

Background:

Available data regarding clinical characteristics of systemic sclerosis-associated myopathy (SSc-M) patients comparing different subgroups of muscle pathology are limited. We aimed to compare clinical and laboratory findings among different subgroups of Thai patients with SSc-M.

Methods:

From January 2010 to December 2019, 27 patients with suspected SSc-M underwent a muscle biopsy. Twenty-three patients with available frozen muscle biopsy specimens for repeating immunohistochemical stained for reviewing were included. There were three subgroups of pathological findings, including immune-mediated necrotizing myopathy (IMNM), non-specific myopthy (NsM), and polymyositis (PM). No fibrosing myopathy was observed. Baseline clinical data and laboratory findings were compared within those three inflammatory myopathies.

Results:

Of the 23 SSc-M, there were 14 females and 19 DcSSc with a mean age and disease duration of SSc of 53.6±7.7 years and 16.4±23.6 months, respectively. Their mean duration from weakness to muscle biopsy was 3.6±6.0 months. There were 14 (60.9%) patients with IMNM, 6 (26.1%) with NsM, and 3 (13.0%) with PM. At the biopsy date, IMNM had a greater prevalence of severe muscle weakness (42.6% vs. 0% vs. 0%) and arthritis (87.5% vs. 50% vs. 0%) than the NsM and PM groups. There was no significant difference among the three inflammatory patterns regarding baseline clinical characteristics, including age, gender, SSc subtype, disease duration, other organ involvements and median values of CK and ESR levels.

Conclusion:

In this study, we found that the pathological findings of Thai SSc-M were IMNM, NsM, and PM. No fibrosing myopathy was observed. SSc with IMNM tended to have more severe baseline muscle weakness and arthritis than the other inflammatory patterns.
Learnings in Digital Health Design: Insights From a Pilot Web App for Structured Note-Taking for Patients With Rheumatoid Arthritis
Authors: Srivastava Ujwal , Dasari Shobha , Shah Neha
Published: October 2023

Background

Patients fail to accurately remember 40% to 80% of medical information relayed during doctor appointments, and most standard after-visit summaries fail to effectively help patients comply with behaviors to manage their health conditions. The value of technology to empower and engage patients in their health management has been shown, and here we apply technology to help patients remember and act upon information communicated during their medical appointments.

Objective

We describe the development of WellNote, a digital notebook designed for patients to create a customized plan to manage their condition, plan for their appointments, track important actions (eg, medications and labs), and receive reminders for appointments and labs.

Methods

For this pilot, we chose to focus on rheumatoid arthritis, a chronic condition that relies on many of these features. The development of WellNote followed a structured method based on design thinking and co-design principles, with the app built in close collaboration with patients and a physician partner to ensure clinical relevance. Our design process consisted of 3 rounds: patient and physician interviews, visual prototypes, and a functional pilot app.

Results

Over the course of the design process, WellNote’s features were refined, with the final version being a digital notebook designed for patients with rheumatoid arthritis to manage their health by helping them track medications and labs and plan for appointments. It features several pages, like a dashboard, patient profile, appointment notes, preplanning, medication management, lab tracking, appointment archives, reminders, and a pillbox for medication visualization.

Conclusions

WellNote’s active and structured note-taking features allow patients to clearly document the information from their physician without detracting from the conversation, helping the patient to become more empowered and engaged in their health management. The co-design process empowered these stakeholders to share their needs and participate in the development of a solution that truly solves pain points for these groups. This viewpoint highlights the role of digital health tools and the co-design of new health care innovations to empower patients and support clinicians.
Correction: Normalizing Telemonitoring in Nurse-Led Care Models for Complex Chronic Patient Populations: Case Study (Preprint)
Authors: Gordon Kayleigh , Dainty Katie N , Steele Gray Carolyn , DeLacy Jane , Shah Amika , Seto Emily
Published: October 2023

UNSTRUCTURED
Phase Angle and Impedance Ratio as Indicators of Physical Function and Fear of Falling in Older Adult Women: A Cross-Sectional Analysis (Preprint)
Authors: Sterner Danielle A. , Stout Jeffery R. , Lafontant Kworweinski , Park Joon-Hyuk , Fukuda David H. , Thiamwong Ladda
Published: October 2023

BACKGROUND

Older adults experience a significant decline in muscle quality and function with aging. Phase angle (PhA) and impedance ratio (IR) measured via bioelectrical impedance analysis (BIA) are both indicative of physical function and cellular health.

OBJECTIVE

This study aim is to characterize the relationships between hand grip strength (HGS), sit-to-stand (STS), BTrackS balance scores, fear of falling (Short FES-1), and IR among older adult women classified as having low or high PhA.

METHODS

A cross-sectional analysis was conducted in 85 older women with a mean age of 75.38 (SD 7.16) years, weight of 71.59 (SD 16.06) kg, and height of 162.74 (SD 6.18) cm. To examine the influence of PhA on performance measures, participants were divided into two PhA groups, high (>4.1°; n=56) and low (≤4.1°; n=29). Data were non-normative, so Mann-Whitney U test was used to evaluate between-group differences and Kendall’s tau coefficients were utilized to determine the partial correlations.

RESULTS

The low PhA group had significantly higher IR (P<.001, rrb=0.92). The high PhA group had greater HGS (P=.007, rrb=0.36), BTrackS balance scores (P =.03, rrb=0.30), and STS scores (P<.001, rrb=0.49) compared to the low PhA group. When adjusted for age among the whole sample, PhA was strongly correlated with HGS (τb=0.748, P=.003) and STS scores (τb=0.764, P=.002). Short FES-1 scores were moderately correlated with IR (τb=0.456, P=.07).

CONCLUSIONS

Results revealed that the low PhA group had significantly higher IR, while the high PhA group demonstrated greater HGS, BTrackS balance scores, and STS scores. Notably, when adjusted for age, PhA showed strong correlations with HGS and STS scores. These findings suggest that lower PhA values, indicative of reduced cellular health, are associated with diminished physical function in older women. Therefore, PhA may serve as a valuable tool for early identification of older individuals at risk of functional decline.

CLINICALTRIAL

ClinicalTrials.gov (NCT06063187)

INTERNATIONAL REGISTERED REPORT

RR2-10.2196/27381
Diabetes mellitus and COVID-19: living with double risk
Authors: Muravlova O.V. , Shaienko Z.O. , Dvornyk I.L. , Sizova L.M. , Ilchenko V.I. , Purdenko T.I. , Shpetnyi O.A.
Published: October 2023

Background. The purpose is to analyze and summarize the studies conducted to determine the impact of COVID-19 on the course of diabetes mellitus and the manifestations of chronic complications of this disease. Materials and methods. We did the search in PubMed and ScienceDirect databases using the following line: “SARS-CoV-2 or COVID-19 and diabetes or hyperglycemia”. Results. It was found that in patients with diabetes, the severity of COVID-19 is increased. In particular, the number of those who needed intensive care or artificial ventilation has elevated. The same negative trend is noted for the overall mortality rate in patients with diabetes. It has been found that COVID-19 contributes to an increase in the development of diabetes, including diabetic ketoacidosis, hyperosmolar syndrome, brain stroke and mental health disorders, which can potentiate the effect of COVID-19 in enhancing the manifestations of diabetes and double risk for these patients. Along with this, the common pathways of the pathogenesis of diabetes and COVID-19 determine the bidirectionality of the interaction in their comorbidity. Conclusions. We have demonstrated numerous links between COVID-19 pathogenetic mechanisms and diabetes. Despite this, current research shows only modest evidence of an increased risk of metabolic, neurological, and psychiatric complications in patients with diabetes who had COVID-19. However, along with the direct impact of patients’ infection, the conditions of pandemic are also affected, which complicate access to the necessary care and should be taken into account when studying the clinical consequences of COVID-19 in patients with diabetes.
Modifikasi Skala Mindfulness
Authors: Ferdian Flaviana Rinta , Helmi Avin Fadilla
Published: October 2023

Penelitian ini bertujuan untuk melakukan modifikasi terhadap skala mindfulness. Peneliti mengggunakan empat aspek mindfulness dan indikator diperoleh dari lapangan melalui open-ended questionaire dan wawancara. Adapun empat aspek tersebut adalah observasi, deskripsi, bertindak dengan kesadaran, serta menerima tanpa menilai pada stimulus internal dan eksternal. Partisipan pada penelitian ini berjumlah 201 orang mahasiswa S1, S2, dan mahasiswa profesi. Skala disebarkan kepada partisipan secara online dan offline. Seleksi item dilakukan dengan menggunakan hasil pengujian validitas isi, analisis daya beda, dan analisis faktor konfirmatori. Dari 48 item tersisa 13 item sebagai skala mindfulness. Hasil analisis menunjukkan bahwa ada tiga aspek yang muncul dalam penelitian ini, sedangkan aspek bertindak dengan kesadaran tidak muncul sebagai dimensi spesifik dalam analisis. Oleh karena itu, penelitian lebih lanjut mengenai aspek tersebut atau perbaikan dalam pembuatan item skala mindfulness perlu untuk dilakukan. Walaupun memiliki keterbatasan, penelitian ini berkontribusi untuk menyediakan item pada aspek deskripsi dan menerima tanpa menilai yang mencerminkan stimulus internal dan stimulus eksternal, yang pada penelitian sebelumnya, banyak item stimulus eksternal yang gugur pada dua aspek tersebut. Oleh karena itu, skala modifikasi mindfulness ini dapat melihat mindfulness pada individu baik terhadap stimulus internal maupun stimulus eksternal.
The Employability of Government Institution: The Role of Job Crafting and Creative Climate Moderator
Authors: Arezah Ersaliya , Himam Fathul
Published: October 2023

The evolution of technology led to rapid changes that affected both organizations and employees. Employability was a term to describe a continuum process of fulfilling the skills and expertise that also changed rapidly. One’s behavior in crafting a job could lead to one’s employability. Organizational climate, which in this study was the creative climate, had a moderating role in affecting the job creation toward employability. This study aimed to explain the role of job crafting in predicting employability in government institution X and creative climate as the moderator. The quantitative approach was applied to this research, by distributing Employability Scale (α = 0.937), Job Crafting Scale (α=0.922), and Creative Climate Scale (α=0.950) to 129 employees of government institution X. The study showed that job crafting significantly predicted the employability (R2 = 56.7%; p = 0.000, p < 0.05) along with creative climate lessened the prediction of job crafting to employability (p = 0.027, p < 0.05). Thus, the hypothesis in this study was accepted. Therefore, it was worth noting that job crafting had benefits for employees’ employability with a constructive, suitable organizational climate.
Psychometric properties of Mental Health Scale: An Item Response Theory Approach
Authors: Marvianto Ramadhan Dwi
Published: October 2023

Indonesia Family Life Survey (IFLS) the fifth wave used the Centre for Epidemiological Studies Scale (CES-D10) to measure mental health state, which was depressive symptoms construct. It was primarily used in some studies regarding depressive symptoms. However, there was no specific validation research in the Indonesian context. Thus, this study aimed to (1) investigate the item quality of depressive symptom measurement from IFLS fifth wave, (2) measurement precision of this scale, and (3) the measurement invariance based on gender using the IRT approach. This study used data from ILFS-5 in the KP ("Keadaan Psikologis" or Mental Health) section, which was CES-D10 consisting of 10 items and conduct IRT analysis using a 2-PL model. The number of participants from the data was 31,447. CFA analysis resulted a unidimensional model fit for this scale. Moreover, finding showed that this scale had good psychometric properties, including item discrimination, item location, and item fit, except item 5 and item 8. Despite the poor quality for those items, the reliability coefficient, including the items, met a reliable measurement criterion. Also, this scale had much information for assessing medium and severe depressive symptoms. Moreover, the Differential Item Functioning (DIF) analysis indicated that there was no item exhibiting DIF.
A Research Paper on Study of Hydraulic Bridge
Authors: Chavhan Prof. M. P. , Gaydhane Bhagyashree G. , Gore Neha R. , Rathod Pranita , Shaikh Fatim , Soban Mohhamad
Published: October 2023

Abstract: Hydraulically assisted bridge a new concept in bridge design which incorporates an in integrated hydraulic system into the bridge in order to carry more weight. The system is most suitable for arch based bridge in which the main forces are directed in a horizontal sideways direction. Predication of the risk to build in infrastructure posed by climate and land use change have suggested that bridge. collapses may increase due to more frequent or intence flooding. Assessment of the united state often assume that bridges may Collapse when the 100year flood occurs but this Assumption has not been fally tested due to lack of comprensize collapse record 35 bridge. for which a stream gauge 35 bridges for which a stream gauge on or near the bridge recorded. The flow during total or partial collapse were identified and used to test this assumption. Flood frequency analyses, and used to test this assumption. Flood frequency analyses, and statistical analyses, other structural reliability methods. Where used to quantity the return periods of collapse. Indusing flows, identify trends linked to event and site characteristics and evaluate the potential importance of collapse return period variability in assessing the impact of climate and land use charge on hydraulic collapse risk.
Structural Architecture and Mineralogical Relationship in Chitradurga Schist Belt, Dharwar Cration, South India
Authors: Ganguly Pekham
Published: October 2023

Abstract: The succession in the late Archaean supracrustal belts in the Chitradurga region begins with basal quartz-pebble conglomerates and quartzites which were deposited on a basement of tonalitic--granitic gneisses, ca. 3000 Ma, containing tracts and enclaves of older supracrustal rocks. Thebasal beds are overlain by basic metalavas and amphibolites interbeddedwith crossbedded quartzites and siliceous phyllites. This series passes up into siliceous phyllites, locally containing a large lenticular mass of polymict conglomerate (Talya Conglomerate), overlain by banded iron formations and siliceous phyllites including sporadic chert pebble conglomerates. Greater subsidence in part of the basin accommodated greater thicknesses of basic volcanic and acid pyroclastic rocks, the latter being more abundant at higher levels. With progressive deepening of the whole basin, finegrained, graded greywackes and local polymict conglomerates (Aimangala Conglomerate) were deposited ; the turbidite sequence forms the youngest sedimentary rocks exposed.Estimated total stratigraphic thickness is at least 10 km indeeper parts of the basin. Deformation led to a series of upright anticlines and synclines and relatedLS fabrics with extreme variations in plunge of the coaxial fold axes and Lfabrics within axial surfaces which maintain a steep orientation. Low-grademetamorphism outlasted the deformation. Sedimentation and volcanism in the Chitradurga supracrustal belt is linkedto variable subsidence of the basement foundation, probably as a result of rifting. The structural evolution of the belt followed as a direct continuation of events that controlled the depositional and volcanic history. Variable displacement of the basement during theselate Archaean events in the Karnataka craton took place on shear zones and related fractures that acted as channels for water and CO: asindicated by vein minerals and alteration products. Uplift of basement segments and their distension by granitic diapirs led to deformation of thesupracrustal cover made ductile by its high water content