bluuebunny/crossref_metadata_2025 huggingface dataset:
Regulations For Implementing Passive Euthanasia In The Terminal Stage Patients (End of Life) Which Is In Accordance With Justice and Legal Certainty In Indonesia
Authors: Dewi Dian Andriani Ratna , Suwarty Haryono Waty , Isretno Israhadi Evita
Published: May 2023

Euthanasia is an act of intentionally not doing something aimed at prolonging someone's life or intentionally doing something to shorten or also end the life of a patient which is carried out to hasten his death, while enabling a good death without unnecessary suffering. Thus, in practice, in a terminal condition, a doctor may or may not perform an act that may result in the death of a patient in accordance with the written request of the patient/family. This dilemmatic condition requires legal certainty in order to uphold justice and humanity as well as legal protection. The problems are 1) How is passive euthanasia applied for terminal patients? 2) How is legal certainty in the application of euthanasia in Indonesia? 3) How is the implementation of euthanasia that meets the community's sense of justice? To answer these problems, a research using normative juridical methods is needed through primary data collection in the form of empirical data from interviews and filling out questionnaires about knowledge and level of agreement on euthanasia. Secondary data in the form of research on primary, secondary and tertiary legal materials. 8The results of the study show that the implementation of regulations in the Act and Ministerial Regulations that lead to the implementation of euthanasia has so far been applied, especially to terminal patients. However, the legal certainty of the act has not been clearly described because there are rules that are not in line. Euthanasia cannot be equated with ordinary homicide. To fulfill justice and humanity as well as legal protection, euthanasia regulations are needed in a harmonious positive law
Realization of Village Fund Utilization to Improve Welfare of Village Communities In Mlarak District, Ponorogo Regency In 2022
Authors: Wahyuningsih Rosyida , Santoso Slamet , Hamidah Choirul
Published: May 2023

Village Fund is a fund sourced from the State Budget (APBN) which is given   directly to villages, andis received through the District/City Regional Budget (APBD) used to finance the implementation of village government, the implementation of development, community, development, and empowerment. This study aims to determine the realization of the use of Village Funds to improve the welfare of the community in Siwalan Village, Mlarak District, Ponorogo Regency. This research uses a qualitative descriptive approach that aims to provide detailed information about the problem to be studied. The primary data source was taken from interviews with informants, while secondary data was taken from government books and documents in Siwalan Village, Mlarak District, Ponorogo Regency.
Effectiveness of Poly Aluminum Chloride Coagulant On The Performance of IPAM Badaksinga, Bandung City
Authors: Artiningrum Tati , Filiceldi Mahesa
Published: May 2023

The Badaksinga Drinking Water Processing Installation is an installation owned by Perumda Tirtawening Drinking Water, Bandung City, has 2 of these installations, the first of which is a design from Degremont - France, built around 1954 with a capacity of 1000 liters/second. The second installation is an IWACO-Dutch design with a flow rate of 800 liters/second. The raw water for the two installations comes from the Cisangkuy River and the Cikapundung River. To purify the raw water, PAC (Poly Aluminum Chloride) is used as a coagulant which is a complex inorganic compound with a clear to yellowish color. The coagulant addition process must be carried out efficiently because this coagulation process is a chemical process that requires a large amount of money for the water treatment process apart from chlorination.  Excessive addition of coagulant doses will cause the cost of using coagulant chemicals to swell so that it will have an impact on overall operational costs. The purpose of this study was to determine the effectiveness of using PAC in reducing turbidity, in the form of the optimum dose of coagulant, turbidity and pH. The method used is the Jar Test which is a tool to test the ability of coagulants to determine the optimum dose in a water treatment process. From the samples, the raw water turbidity varied from 17.1 to 281 NTU, fluctuating due to geographical location and environmental conditions around each and the degree of acidity or an average pH of 7.13. After the Jar Test was carried out, the optimum dose was produced at a coagulant concentration of 30 mg/l resulting in turbidity in the range of 1.1 to 5.0 NTU and an average turbidity reduction efficiency of 94.5%, the pH of raw water, after coagulation and flocculation with the Jar Test simulation tool, there was a decrease of 4.1% to an average of 6.99. This result is in accordance with Minister of Health Regulation No 492/MENKES/PER/10/2010 April 19 2020, namely turbidity of no more than 5 NTU and a pH of 6.5 – 8.5
Measuring Switch Intention In The Push Pull Mooring Framework For Self Service Technology Products: Kios Matic Bright Gas
Authors: Chairon Djasmy Roby , Sobari Nurdin
Published: May 2023

This study examines the factors that influence the intention to switch customers in purchasing LPG Bright Gas products from the conventional way to purchasing through Kios Matic (self-service kiosk) using the Push-Pull Mooring model. The method used is a quantitative measurement of online survey questionnaires on 203 respondents in Jakarta with experience using Kios Matic at least 1 time. The measurement uses the SEM method to analyze research acquisition data. The results showed that the Push, Pull and Mooring factors had an influence on switching intention of the Bright Gas customers. Validation of the factors that most influence customer switching intentions can be a reference for self service providers, so that companies can formulate marketing strategies to anticipate customer switching intentions
Policy Implementation Green Public Procurement In Sustainable Development In South Kalimantan Province
Authors: Ansari Husin , Nurdin Nurliah , Tahir Irwan , Maryani Dedeh
Published: May 2023

Development is a process of change towards better conditions through planned efforts aimed at improving the welfare of the people by involving supporting elements, namely human resources, natural resources and technology. The three elements must synergize well so that inequality does not occur as a result of the development process both in terms of economic, social and environmental.  The approach used in this study is a qualitative approach, with an exploratory method. Locke, Spriduso and Silferman put forward: ―qualitative research is interpretative research. As such, the biases, values and judgment of the researches become stated explicitly in the research report. Such openness is considered to be useful and positive.  Based on the perspective of Meter and Horn theory (1975) which states that implementation will be the most successful where only small changes are needed and a consensus of high goals, broadly speaking, the implementation of GPP policy in South Kalimantan has not been optimal because the small changes needed have not been achieved, while the consensus goals have not been achieved properly
The Effect of Green Finance On Stock Price Volatility
Authors: Pardomuan Siregar Ernst Tunggul , Satria M Bangkit Nata
Published: May 2023

This study aims to determine the effect of green finance (green accounting) on stock price volatility.  Stock price volatility is the movement of up and down stock prices on the stock exchange. In this study, the sample used was mining companies listed on the Indonesia Stock Exchange for the 2013-2018 period with a total population of 46 companies. With purposive sampling technique, get 18 companies as samples. This study used the panel data regression method with a common effect model approach. The results showed that a green finance has a positive effect on stock price volatility.  Information asymmetry as a moderation variable cannot amplify the influence of green finance on stock price volatility, and also the effect of quality environmental and social disclosures on stock price volatility
The Role, Function, and Position of Language In Everyday Life
Authors: Fransisca Vika
Published: May 2023

The purpose of writing this article is to know that language is very important in everyday life.  Man himself is a social being who cannot live alone and definitely needs the help of others.  With human language it will be easier to communicate with each other.  In every-day life, The Indonesian   language plays a very important role, the Indonesian language plays a unifying role meaning that the differences in language and culture of the Indonesian people can be united into one i.e.  Indonesian. Indonesian can be used as a national language or a language of unity, a state language, and as a development of national culture and technology. Indonesian has its own function.  With the existence of a language social inter-action will work well, due to the presence of communication and mutual relations with each other.   If humans have used Indonesian properly and correctly in accordance with their functions, it will affect the character and character of the human being.  To realize the character of the   nation, the next generation of the nation needs to be given learning about the good  and correct use of  Indonesian, both orally, nor writing
Application of Block-Based K-Medoids and Ward's Method to Classify Provinces in Indonesia Based on Environmental Quality Index
Authors: Kariyam Kariyam , Abdurakhman Abdurakhman , Ronnie Effendie Adhitya
Published: May 2023

Environmental quality is an essential aspect of the world's sustainability. This paper presents a combination of several methods to obtain a profile of provinces in Indonesia according to the environmental quality indices. We apply the block-based k-medoids algorithm, Ward's method, and the Hartigan index to determine the number of clusters. Based on Hartigan index suggested classifying 34 provinces in Indonesia into four groups. A comparison of the mean vector of four groups using multivariate analysis of variance concluded that three areas have the best environment quality index and eight regions require serious attention to improve their environmental quality methods.
Implementation of Special Autonomy Policy In The Health Sector In Wondama Bay Regency West Papua Province
Authors: Nunaki Eduard , Jeddawi Murtir , Hermansyah Djo , Misrowa Hyroni
Published: May 2023

The degree of public health and health services has not shown results that are in line with the objectives of the special autonomy policy. The data shows that the infant mortality rate (IMR) is still high and the maternal mortality rate is still high. The aim of the research is to analyze and explain the implementation of the autonomy policy, especially in the health sector, the influencing factors and to formulate a new model regarding the implementation of the special autonomy policy in the health sector in Wondama Bay Regency, West Papua Province. This research uses implementation policy theory put forward by Grindle which consists of content policy and implementation context policy. The research approach used in this research is a qualitative approach with a descriptive research type. Data collection techniques were carried out by interviews, observation and documentation. Data analysis techniques used were data reduction and conclusion. The results of the study show that the implementation of the special autonomy policy in the health sector is not optimal, thus it needs to involve many components (authority, affairs, finance, resources, attitude of implementers, community participation and so on). The "NUNAKI" Policy Implementation Model is a construction of research results consisting of three elements, namely: commitment, communication and collaboration. The implementation of the "NUNAKI" model requires five basic prerequisites, namely: regional authority, regional institutions, state finances, local government politics and the effectiveness of coordination, guidance and supervision.
The Hermeunetic Concept of The Qur'ān Muhammad Shaḥrūr
Authors: Nur Arafah Nawal
Published: May 2023

The purpose of this paper is to elaborate on the developmentof the qur'ān's pentak wilan transformation from a literal (textual) approach to a contextual approach by the hermeneutic method initiated by the contemporary Muslim intellectuals of Shaḥrūr. The idea of Shaḥrūr can beused as a method of interpreting the Qur'ān in this era of globalization so that Muslims can continue to adapt to the times.  This paper is written using a library research model, because the objects of study are things related to various literature literature. This research uses a philosophical-hermeneutical method that is included in the qualitative approach, which intends to understand phenomena about the object of study, with the method of description in the form of words and language (narrative).  Shaḥrūr introduced a linguistic approach called al-manhaj al-tarīkhī. Initially, he combined the linguistic methods of Abū 'Alī al-Fārisī, Ibn Jinnī, and 'Abd al-Qadīr al-Jurjāni. But eventually Shaḥrūr concluded the absence of synonyms in Arabic and Shaḥrūr also made Mu'jam Maqāyis al-Lughah by Ibn Fāris, one of the adherents of the absence of synonymity, his mandatory reference. It was this absence of synonymity that later became one of the principles of the Shaḥrūr method of interpretation. In addition to the synonmatic denial in the hermentic method Shaḥrūr is identical about the theory of hudud or limit.
The Analysis of Work Engagement and Self Efficacy Towards The Self-Development of Tourism Entrepreneur In Labuan Bajo and Timor Is-land
Authors: Nursiani Ni Putu Nursiani , E. Fanggidae Rolland , Yoga Salean Debryana , Kurniawati Merlyn , H. Lada Jachielin
Published: May 2023

East Nusa Tenggara is a province that has great natural wealth and tourism potential. The enthusiasm tourists to visit tourist objects in NTT is quite large, seen from the increase in tourist visits every year. The current phenomenon of tourism turmoil in NTT creates many opportunities as well as threats to the sustainability the sustainable tourism industry in the future. A gap like this creates opportunities for human resources in tourism sector  increase economic contribution to the region. One strategy that can be implemented is to encourage more business actors in the tourism sector and develop the self-capacity of business actors who already exist in the world of tourism. Apart from that, it is also important to increase the capacity and professionalism of human resources for tourism and the creative economy, so that the competitiveness of tourism in NTT can also increase. In an effort to maximize the achievement these goals, human resources (HR) are needed who have the competence, knowledge, ability, productivity and good performance. Efforts to meet the objectives  increasing the capacity and professionalism maximum tourism human resources involve self-efficacy and strong work involvement from within the business actors. This study aims to analyze Work Engagement and Self-Efficacy in Self-Development  Business Actors in the Tourism Sector in NTT. The research was conducted by studying the phenomena and entrepreneurial behavior the tourism sector in Labuan Bajo (a tourist city with the highest tourist visit rate in NTT) and Timor Island (an area with the second highest tourist visit rate).
Problems of The Teacher Profession In Indonesia (Review From The Perspective of Law Number 14 of 2005)
Authors: Saekan Mukhamad
Published: May 2023

The Teacher profession is carried out through planning, implementing and evaluating learning. Teachers are called professionals if they are able to carry out learning properly and correctly which is shown by the skills to carry out learning techniques, methods, approaches and strategies properly and correctly. Every hour of learning The teacher must be in the school, if at the time of school hours being outside the school without justifiable reasons is categorized as having committed a violation of the teaching profession.  The purpose of this study is to determine the problems of the teacher profession in Indonesia.  By using the PTK research method carried out in schools. The results obtained are that the professionalresponsibility of teachers is carried out through planning, implementing and evaluating learning in schools. Consequently, therefore teachers must have a variety of knowledge and skills and have a sense of security and comfort in carrying out their professional duties.
The Effect of Self-Assessment System Justice Taxation, and Distrust of The Fiscus Party To The Act of Tax Evasion By The Taxpayer
Authors: Biettant Rubiatto , Syahdila Miftah , Charlie Charlie , Alvin Maulana Fahmi
Published: May 2023

This study aims to examine the effect of the Self Assessment System, Tax Justice, Distrust of Tax Officers on the act of Tax evasion. The independent variables in this study are the Self Assessment System, Tax Justice, and Distrust of tax officials, while the dependent variable is the act of tax evasion. This study uses primary data by distributing questionnaires to taxpayers. 367 questionnaires have been distributed to taxpayers in the KPP Pratama Jakarta Gambir 4 area. The method used in this study is convenience sampling. Data analysis using multiple regression analysis data. The results of this study indicate that the Self Assessment System, Tax Justice has a negative effect on the act of tax evasion, while distrust of tax officials has a positive effect on the act of tax evasion. Based on the results of data analysis and discussions that have been carried out, it can be concluded that the self Assessment System does not have a significant negative effect on tax evasion actions
College Bus Location Tracking and Stop Notification System using Lora WAN
Authors: M Abinash , S Mohanram , G Vinodhan , K Dr. Bala subramaniyan
Published: May 2023

The advanced environment is recommended by a variety of technology day by day. Often the associated changes in technologies are improving advanced business methods. Several technologies have been exhibited in the system for growing people's life more comfortable and healthier day by day. Android is the newest and rapidly developing technology available for all users or users in today's business. A tremendous rise in end- user assent has been encountered in the past few years. The plan is based on the latest GPS technology using IoT which permits the college students to track the movement of the college buses and maintain a schedule as well as implement real-time bus locations for the users. Unique and stunning conditions on the roads affect the smooth operation of the bus system and the change of vehicles. Also, daily difficulties such as traffic, sudden delays, broken vehicle dispatching incidents take place, and as an outcome of which the program of the students is affected and they necessarily have to wait for the arrival of their particular bus and also attempt to miss their bus. The foremost objective of this application is to render the specific location of the user's respective buses in Google Maps and also joined with the specialty of emitting an alarm signal to the driver if the user is beside the bus stop. It is the real-time system as the current location of the bus is renewed every moment in the form of latitude and longitude which is received by the user by their application with the help of Google Map API. Management and College Bus Operation teams access real-time fleet tracking with live vehicle locator. Monitor operational performance by run, route, driver, time of day, day of week, and length of travel times. Track ridership statistics and usage data to make informed decisions about routes needs and frequency of service Create canned messages for students using the CTGo app to advise of stop changes due to road construction and/or temporary street closures. With our innovative College bus tracking system students can track their bus using CTGo Apps or receive SMS notification just 5-10 minutes before bus reaches their designated stop. Key Word: Google Map API; CTGo app; IoT; College bus
APLICAÇÃO DA LÓGICA FUZZY PARA ESTRATÉGIAS DE COMPRAS EM UMA INDÚSTRIA DE VIDROS
Authors: Castanhetti Liliane da Silva , Rojo Cláudio Antonio , Bulhões Ronaldo
Published: May 2023

O objetivo deste trabalho foi aplicar a Lógica Fuzzy para elaborar estratégias para classificação de portfólio de compras em uma indústria de vidros. A coleta de dados foi realizada junto ao setor de compras da referida indústria. Para mensuração dos dados foi utilizado o software InFuzzy com análise descritiva. Como resultado observou-se que 94,5% dos produtos, encontram-se no quadrante de itens estratégicos na Matriz de Portfólio. Destes produtos 60%, estão posicionados no quadrante classificados com a estratégia de “explorar”. Os resultados apontaram que o setor de compras da indústria Alfa carece de planejamento estratégico para reduzir custos.
TRANSFORMAÇÃO DIGITAL EM FINANÇAS
Authors: Duarte Rodrigo Garcia , Luft Maria Conceição Melo Silva , Freitas Florence Cavalcanti Heber Pedreira de , Silva Marcio Roque dos Santos da , Matos Júnior José Ednilson , Silva Débora Eleonora Pereira da
Published: May 2023

O artigo evidencia o processo corrente de transformação digital em finanças com a utilização em novos modelos de negócios ao explorar as possíveis contribuições da Visão Baseada em Recursos e das Capacidades Dinâmicas nesse campo organizacional. Para tanto, verificou-se que os recursos tecnológicos utilizados na transformação digital em finanças não constituem fonte de vantagem sustentável. As capacidades dinâmicas organizacionais, por sua vez, combinam-se de forma eficiente em incumbentes e em grandes empresas de tecnologia que demandam capacidade de inovação típicas de fintechs em um processo contínuo e dinâmico, ao passo que as empresas não tradicionais preferem as parcerias pontuais.
GESTÃO DA INFORMAÇÃO E DO CONHECIMENTO NA CADEIA DE SUPRIMENTOS 4.0
Authors: Ribeiro Jurema Suely de Araújo Nery , Ziviani Fabricio , França Renata Souza , Correa Fabio , Ferreira Eric de Paula
Published: May 2023

As tecnologias adotadas nas transações das cadeias de suprimentos, mais propriamente nos processos produtivos, têm sido responsáveis por possibilitar a quarta revolução industrial através da personalização da produção em massa, processos de produção inteligentes e viabilização da inovação nos modelos de negócios. Torna-se primordial neste contexto o estabelecimento de um sistema de informação integrado, que facilite a inovação e a difusão do conhecimento ao longo da cadeia de suprimentos. Diante da crescente importância da cadeia de suprimentos 4.0, bem como, da indústria 4.0 nela inserida, e partindo do pressuposto que os sistemas de informação são componentes integrais dos sistemas de gestão do conhecimento, este artigo objetivou identificar, por meio de publicações científicas, como os sistemas de informação podem possibilitar um ambiente propício ao gerenciamento do conhecimento para obtenção de maior competitividade na cadeia de suprimentos 4.0 e na indústria 4.0. Foi empreendida pesquisa qualitativa, de natureza exploratória-descritiva e bibliográfica quanto aos meios, por relacionar referências publicadas e discutir as contribuições cientificas dos construtos pesquisados. Por resultado, foram indicadas ferramentas tecnológicas usadas para viabilizar o gerenciamento do conhecimento em cadeia de suprimentos 4.0 e na indústria 4.0, a fim de aumentar a competitividade e alavancar o seu desempenho. Posteriormente, foram identificadas algumas orientações de pesquisa futuras.
INFLUÊNCIA DOS RECURSOS INTANGÍVEIS NO DESEMPENHO EM RESTAURANTES GASTRONÔMICOS
Authors: De Oliveira Alves Luana , Santos Salazar Viviane , Sales Melo Francisco Vicente
Published: May 2023

Este artigo analisa a relação entre recursos intangíveis e desempenho em restaurantes gastronômicos. Para tanto, propõe-se a Escala de Recursos Intangíveis (ERINT) para mensurar reputação, recurso relacional e recurso humano. Por meio de um survey, sessenta e cinco gestores de restaurantes do Brasil foram acessados. Demonstrando ser adequada para análises dos recursos intangíveis em restaurantes, a escala proposta permitiu verificar que, o recurso humano, melhora o desempenho nos restaurantes. Conclui-se que a ERINT é relevante na mensuração de recursos intangíveis, especialmente no segmento de serviços. E, para se obter alto desempenho, restaurantes gastronômicos devem investir no desenvolvimento de competências pessoais.
INTENÇÃO DE COMPRA DE PRODUTOS COM COMPONENTES RECICLADOS
Authors: Garcia Daniele Rodrigues , Tondolo Vilmar Antonio Gonçalves , Tondolo Rosana da Rosa Portella , Brambilla Flávio Régio , Longaray André Andrade
Published: May 2023

A preservação de recursos esgotáveis pode ser realizada pela oferta de produtos e/ou serviços sustentáveis. Nesse sentido, observa-se a necessidade de aprofundar estudos sobre intenção de compras de produtos produzidos com componentes reciclados, ofertados por empreendedores sustentáveis. O objetivo desta pesquisa é verificar o efeito moderador da orientação sustentável e do valor da marca no efeito do tempo do empreendimento na intenção de compra. Realizou-se um estudo cross-country, com experimento de campo baseado em cenários, entre brasileiros e uruguaios, empregando-se a técnica de análise de regressão múltipla. Os resultados apontaram diferenças entre consumidores de ambos os países.
PERFIL DE EDUCAÇÃO FINANCEIRA DOS DOCENTES DE UNIVERSIDADES PÚBLICAS BRASILEIRAS
Authors: De Abreu Pontes Gleison , De Souza Costa Patrícia , Merhi Rangel Ahssyma
Published: May 2023

O estudo propõe identificar se fatores demográficos e socioeconômicos afetam a percepção e o nível real de educação financeira dos docentes de graduação e pós-graduação de instituições de ensino superior (IES) públicas brasileiras. O levantamento, realizado por meio de um questionário online, resultou em 549 respostas válidas, analisadas por meio de regressão linear. O estudo evidenciou que os docentes superavaliaram o conhecimento que possuem sobre educação financeira. Gênero, idade, possuir dependentes e renda, afetam o nível de educação financeira percebido e real. A graduação na área de negócios, influencia positivamente na educação financeira que os docentes possuem.
CONTRIBUIÇÕES À INTENÇÃO EMPREENDEDORA EM PESQUISA GLOBAL SOBRE EMPREENDEDORISMO
Authors: Bizarria Fabiana Pinto de Almeida , Barbosa Flávia Lorenne Sampaio , Lourenço Marceane Barros , Ribeiro Rogeane Morais
Published: May 2023

Para analisar contribuições à intenção empreendedora, utilizou-se o Global University Entrepreneurial Spirit Students’ Survey (GUESS), com 195 respondentes universitários em Universidade Federal brasileira. A modelagem estrutural foi estimada, com o software SmartPLS, após verificadas validade e confiabilidade, capacidade explicativa, relevância relativa e capacidade preditiva. Resultados: influência positiva e importante capacidade explicativa do clima empreendedor em relação ao programa de aprendizagem; influência positiva e média capacidade explicativa entre o programa de aprendizagem e a autoeficácia empreendedora; Influência positiva e elevada capacidade explicativa da autoeficácia sobre a atitude empreendedora; influência positiva e importante capacidade explicativa da atitude sobre a intenção empreendedora.
ELEMENTS OF COOPETITION STRATEGY
Authors: Oliveira-Ribeiro Rodrigo , Chim-Miki Adriana Fumi
Published: May 2023

The research examines 129 coopetition models through a qualitative-quantitative study performed using the IRAMUTEQ software to provide the dimensions and variables with more representativeness in the coopetition strategy literature. We used three techniques: Lexical analysis, Descending Hierarchical Classification, and Similarity Analysis. The results showed one macro dimension and two subdimensions divided into six classes. The elements hierarchy was the Creation of coopetitive value, Coopetitive orientation, Strategic adjustment, Coopetitive alliances as determinants, Perceived benefits, and Organizational profile. Similarity analysis results validated both the hybrid nature of coopetition and applications of the construct in market environments and related to cooperative knowledge sharing.
Advanced approaches for selective investigation of neuronal function and circuitry: The future of developing novel therapeutic strategies in neuropharmacology?
Authors: Joksimović Srđan , Joksimović Sonja
Published: May 2023

Recent advances in neuroscience techniques and methods ushered in a new era in the research of neuronal function with unprecedented selectivity and temporal resolution. One of the main characteristics of these technical advances is the ability to selectively target and/or modulate specific neuronal subpopulations and circuits in both healthy and diseased brains. Although initially designed as tools to help researchers better understand the mechanisms underlying neuronal activity and complex behaviors, these novel approaches may also accelerate the process of drug discovery in many areas of neuroscience, and some may even potentially serve as novel therapeutic strategies. The application of different electrophysiological techniques is still considered essential in studying ion channel function and pharmacology, as well as network-level changes in brain activity. The cutting-edge methods for investigation of brain function include opto-and chemogenetics in freely behaving animals; both approaches enable highly selective control of neuronal activity using either a light stimulation (optogenetics) or a chemical ligand (chemogenetics) in both loss-and gain-of-function experiments. In this review paper, we aim to summarize recent scientific evidence on the state-of-the-art and provide information on these advances, taking into account both academic and pharmaceutical industry points of view.
KEAP1/NRF2 as a druggable target
Authors: Dinkova-Kostova Albena
Published: May 2023

Nuclear factor erythroid 2-related factor 2 (NRF2; encoded by NFE2L2) is an inducible transcription factor that regulates the expression of a large network of genes encoding proteins with cytoprotective functions. NRF2 also has a role in the maintenance of mitochondrial and protein homeostasis, and its activation allows adaptation to numerous types of cellular stress. NRF2 is principally regulated at the protein stability level by three main ubiquitin ligase systems, of which the regulation by Kelch-like ECH-associated protein 1 (KEAP1), a substrate adaptor protein for Cul3/Rbx1-based ubiquitin ligase, is best understood. KEAP1 is a multi-functional protein and, in addition to being a substrate adaptor, it is a sensor for electrophiles and oxidants. Pharmacological inactivation of KEAP1 has protective effects in animal models of human disease, and KEAP1 is now widely recognized as a drug target, particularly for chronic diseases, where oxidative stress and inflammation underlie pathogenesis. Many compounds that target KEAP1 have been developed, including electrophiles that bind covalently to cysteine sensors in KEAP1, non-electrophilic protein-protein interaction inhibitors that bind to the Kelch domain of KEAP1, disrupting its interaction with NRF2, and most recently, heterobifunctional proteolysistargeting chimeras (PROTACs) that promote the proteasomal degradation of KEAP1. The drug development of KEAP1-targeting compounds has led to the entry of two compounds, dimethyl fumarate (BG-12, Tecfidera®) and RTA-408 (omaveloxolone, SKYCLARYS®), in clinical practice. In 2013, dimethyl fumarate was licenced as the first oral first-line therapy for relapsingremitting multiple sclerosis and is also used for the treatment of moderate-to-severe plaque psoriasis. In February 2023, omaveloxolone was approved by the United States Food and Drug Administration as the first and only drug for patients with Friedreich's ataxia.
Current role of tribological tests: Striving for full characterization of medicinal and cosmetic products
Authors: Tošić Anđela , Stanković Tijana , Ilić Tanja , Savić Snežana , Pantelić Ivana
Published: May 2023

Tribology investigates the events that happen on the surfaces of two substances/objects that are in direct or indirect contact through assessing friction, lubrication and/or wear. In particular, friction measurements could provide the information on the textural characteristics of (per)oral pharmaceutical preparations and contribute to the understanding of palatability. On the other hand, tribological tests have been more intensively used to characterize topical preparations (pharmaceutical, cosmetic), giving a thorough insight into the tactile and texture properties of these preparations. However, these tests are often combined with rheological, textural, and certain biophysical approaches. Additionally, the materials used for constructing artificial joints and articular cartilages are true tribological systems, developed and optimized in order to have properties that resemble the natural ones. Since tribological studies can be used to assess a wide range of drug dosage forms and products in general, the equipment used may be quite diverse. Accordingly, a special section of this work is committed to the description of the testing equipment's specifications and the applied protocols. The investigation of recently regulatory discovered phenomena, such as transformation/metamorphosis of the vehicle/base of topical preparations, have brought tribology back into focus as a potential assessment method.
Employment effects of technological innovation: Evidence from Nigeria's economic sectors
Authors: Adeyemi Afolabi
Published: May 2023

Technological advancement continues to revolutionize the labor market and has particularly intensified the debate on its employment effect across developing and developed economies. Employing the Autoregressive Distributed Lag (ARDL) framework, this study provides insights into the employment-innovation nexus across the Nigerian economic sectors using the quarterly data from 2011Q1 to 2021Q4. The findings reveal that the employment-innovation nexus is a short-run phenomenon in Nigeria and that technological innovation enhances employment generation in the service sector and the agricultural sector, but it takes a quarter before the positive employment effect occurs. Overall, the results suggest that technological innovation improves employment and reallocates labor across the sectors, which suggests the need to fully operationalize technological innovation across the Nigerian economic sectors in order to tackle the prevailing unemployment conundrum in the country.
Business and institutional determinants of effective tax rates in Serbian banks
Authors: Putica Maja
Published: May 2023

The objective of the current paper is to study the influence of the selected business and institutional determinants on the annual effective tax rates in banks in the Republic of Serbia (RS). Panel data regression models are applied on 113 observations, covering the period from 2017 to 2021, where the accounting and current effective tax rates are used as a measure of the actual tax burden. The results show that the effective tax rate in banks in RS is significantly below the statutory level. Furthermore, for each data set, the coefficients of changes in the effective tax rate are calculated, and the most adequate model is selected using the Hausman and Breusch-Pagan tests. In the first model, the biggest change in the effective tax rates is caused by change in leverage, merger and aquisition processes and the bank size. The presence of loan loss provisions in the model completely highlights the impact of profitability and leverage. Finally, in the last model, banks with a profit before tax can manage effective tax rates and tax burdens by regulating capitalization levels. The results of this study are of interest for economy creators and for business managers in banks, helping them in effective tax planning and managing the results.
Exploring youth unemployment in Morocco: Evidence from micro-level data
Authors: El Foutoun , Kchikeche Ahmed , Mafamane Driss
Published: May 2023

This paper explores youth unemployment in Morocco using the Labor Force Survey of the 2019 data to estimate a logit model. The paper provides the evidence for the three categories of possible determinants of youth unemployment in Morocco. The first set of determinants are the geographic and sociodemographic characteristics such the sex, age, the marital status and the area of residence. Secondly, the socioeconomic factors such as the young people's family background and the number of workers per household play a decisive role in explaining youth unemployment in Morocco. Thirdly and finally, the results obtained in this study show that (regardless of their diplomas) young graduates are more likely to be unemployed than persons without a diploma. However, the influence a diploma type has on the probability of being unemployed varies according to the diploma type. The results obtained shed a light on the important characteristics of youth unemployment in Morocco and should serve as a guide for future research in more specific knowledge gaps.
Smart governance: Payment transaction electronification acceptance in North Sumatra Province, Indonesia
Authors: Satria Dias , Juniar Soewardi , Maharani Wibowo
Published: May 2023

The policy of the electronification of regional payment transactions (ERPT) is one of the innovations implemented by Indonesia due to the COVID-19 pandemic so as to increase the economic activity and revenue. This study is aimed at increasing the understanding of smart governance, the contactless economy, and regional income in North Sumatra Province, Indonesia, and globally the new normal and the post-COVID-19 eras. This research study was carried out using the primary data obtained through questionnaires in 2021 applying the purposive sampling method and processed using the Structural Equation Model-Partial Least Square (SEM-PLS) models. Based on the six hypotheses proposed in this study, the results show that performance expectancy, the social influence, and the facilitating condition have a positive and significant impact on the behavioral use of the noncash payment transactions of taxes and levies in North Sumatra Province. On the other hand, the effort expectancy has no significant impact on the cashless transaction of paying taxes and levies in the North Sumatra Province.
GIIPS and inflation convergence, two decades and few crisis later
Authors: Popović Svetlana
Published: May 2023

Paper analysis inflation convergence in Greece, Italy, Ireland, Portugal and Spain (GIIPS). These countries were severely hit by financial and debt crisis and had to undertake deflationary adjustment programs, thus we wanted to understand weather those conditions reduced imbalances in Eurozone. We used statistical indicators and indicators of s-convergence to study the diversity of their inflation processes. Unit root test on the series of standard deviations of inflation differentials was used to check statistical significance of inflation convergence. Data was divided in two subperiods, from 1997-2008, and 2009-2022, to understand the influence of crisis and austerity measures on asymmetries and divergence of inflation. Results showed significant convergence until the crisis, than differences started to increase. This findings are important while inflation rises since 2021, and it again brought significant divergence between members' inflation rates. Should we fear of a new debt crisis, were the differences sufficiently reduced and imbalances removed?
Protection of consumers rights in life insurance contracts
Authors: Zarubica Sara , Korica Svetlana
Published: May 2023

Life insurance is a special type of activity exerting a strong influence on a country's social and economic structure. Its main field of interest is human life. Life insurance contracts are founded on the basis concept of the legal position of an insured person as the weaker contracting party either due to his/her knowledge of the insurance service and the circumstances surrounding it or due to his/her negotiating position and the financial means put at his/her disposal. The insurer is a trader and professional, which cannot be said for the insured person, who, accordingly, should be ensured protection within the current legal framework. In that sense, it is essential the security and protection of the insurance beneficiary to be provided against all the risks and irregular actions which can be anticipated and prevented. In accordance with the importance of its topic, the paper touches upon the term and characteristics of life insurance contracts. It also includes the definition of life insurance and legal aspects of life insurance contracts, all of which to be followed by a detailed elaboration on the selected topic of the paper, which is reflected in its subtitle-the analysis of consumers (insurance beneficiaries) protection in insurance contracts generally speaking and in life insurance contracts in particular.
Suspended sentence with custodial supervision in Serbia: What does custodial supervision involve?
Authors: Đuričić Nada
Published: May 2023

Suspended sentence with custodial supervision represents an alternative sanction that the legislation of the Republic of Serbia has known for half a century, but its application is rare because it is ordered in a negligible number of cases. Ordering custodial supervision has its advantages and it can be effective in cases when it is not enough to just sentence a person conditionally nor would it be justified and effective to punish the individual more severely, but it is necessary to ensure some sort of help and support in order to correct the offender's behavior and deter them from committing criminal acts in the future. In order to better understand this sanction and see how it works in practice, we have analyzed measures of custodial supervision which are most often prescribed in accordance with the committed crimes. The paper uses a statistical and comparative method and analyzes the available literature, as well as the judgments of those courts that in a certain observed period had the largest number of suspended sentences with custodial supervision.
Adaptation of the entrepreneurship competences questionnaire: When entrepreneurship is more than just business
Authors: Čopková Radka , Gróf Marek , Zausinová Jana , Siničáková Marianna
Published: May 2023

Background Since 2006, entrepreneurship competence has been considered one of the eight key competences for lifelong learning, which are important for personal development, social inclusion, active citizenship, and employment. In 2015, the EntreComp framework was created. The framework structures partial entrepreneurship competences to support their development in European citizens regardless of the field of education, professional or occupational orientation, as a critical part of increasing competitiveness and innovation potential of a country. Purpose: The present paper aimed to develop a questionnaire based on the EntreComp framework, which would serve as a self-assessment tool for one's entrepreneurship competences, which could be used to adopt curricular or extra-curricular and non-formal, education to better serve this goal. Study design/methodology/approach: The validity and reliability of the questionnaire was examined on a sample of university students in different fields of study-technical and natural sciences, humanities, economics, and medicine. The purpose of the sample diversity is the emphasis on the independence of entrepreneurship competence on professional orientation. Findings/conclusions: The result of the study is a 60-item questionnaire consisting of three factors and fifteen subfactors helping to identify educational needs in the field of entrepreneurship, based on the subjective perception of the individual. In comparison with already existing tools, this questionnaire was developed on the strong basis of EntreComp framework and supports the idea of the broader context of entrepreneurship competence than just the business level, while covering cognitive, personal, and behavioural level of the entrepreneurial potential. Limitations/future research: In the future, its application in other age or social groups is suggested.
Gilles Deleuze and the desert island as a material utopia
Authors: Parsa Mehdi
Published: May 2023

This essay seeks to unpack the idea of the absence of others as a primary structure, distinguished from the other as structure and the ego as the empirical result of the structure-other, which is formulated by Gilles Deleuze, particularly in “Michel Tournier and the World Without Others”. Going from the neurotic nature of the structure-other to the psychotic nature of the absence of others as structure I argue that this transition is crucial to reach the “Great Health”, marking a utopian point in Deleuze’s work. I distinguish private from social schizophrenia, claiming that the latter underlies a new communicability which is more corporeal than conceptual. It would also mark an economy which departs from an exchange economy to approach Bataille’s idea of solar economy. Finally, I describe the structural aspect of the dissipation of the other, or social schizophrenia, through the perverse structure, which stands against the pervert’s actual behaviors.
Estudio piloto sobre la utilidad clínica y aceptabilidad del Protocolo Unificado para el tratamiento transdiagnóstico de trastornos emocionales en formato online y grupal en Argentina
Authors: Celleri Milagros , Cremades Camila Florencia , Rojas Rodrigo Lautaro , Garay Cristian Javier , Osma Jorge Javier
Published: May 2023

El objetivo del presente estudio fue aportar evidencia sobre la utilidad clínica preliminar y la satisfacción con el tratamiento del Protocolo Unificado (PU) de Barlow et al. (2011), aplicado en formato grupal y online en adultos con trastornos emocionales en Argentina. Para tal fin se realizó un estudio no controlado con medidas pre y post-tratamiento. El grupo estuvo formado por siete participantes con sintomatología del espectro ansioso-depresiva. La intervención consistió en 11 sesiones semanales sincrónicos de 90 minutos realizados en una plataforma virtual. Los resultados mostraron una reducción significativa en los niveles de depresión, desesperanza, dificultades en la regulación emocional y afecto negativo, y un aumento significativo en la calidad de vida. A su vez, se observaron tamaños del efecto grandes para depresión, ansiedad, desesperanza, dificultades en la regulación emocional y afecto negativo. Los resultados preliminares del presente estudio sobre la utilidad clínica y aceptabilidad del uso del PU en formato grupal y online en población argentina son prometedores
RANCANG BANGUN ALAT KALIBRASI DIGITAL PRESSURE METER MENGGUNAKAN ARDUINO UNO
Authors: Riyan Hapipi Lalu , Arief Hidayat Muhammad , Dwi Anggraynie Ratih
Published: May 2023

Sphygmomanometer merupakan alat yang dibutuhkan dalam proses diagnosa penyakit yaitu melalui pengukuran tekanan darah. Kelayakan dan kualitas sebagai acuan untuk memperoleh hasil yang sesuai, sphygmomanometer yang baik dan laik pakai harus dikalibrasi terlebih dahulu. Penelitian ini bertujuan untuk mengetahui tingkat keakurasiannya nilai pengeluaran dari Sphygmomanometer Anaroid. Metode yang digunakan dalam penelitina ini adalah pendekatan yang digunakan dalam penelitian ini adalah pendekatan kuantitatif. Pengertian penelitian kuantitatif adalah metode penelitian yang menggunakan proses data-data yang berupa angka sebagai alat analisis dan melakukan kajian penelitian, terutama mengenai apa yang sudah diteliti. Data yang ingin diteliti berupa hasil pengeluaran dari Sphygmomanometer Anaroid. Rancang bangun alat kalibrasi digital pressure meter menggunakan Arduino uno yang dimana sampel utamanya terdiri dari komponen elektronika diantaranya berupa sensor MPX5100DP yang diperuntukan sebagai alat untuk membaca tekanan dengan bantuan Arduino uno sebagai otak untuk menjalankannya dan menghubungkannya menggunakan kabel jumper yang hasil tampilannya berupa LCD 16x2.