bluuebunny/crossref_metadata_2025 huggingface dataset:
Genome-Wide Analysis of miR159 Gene Family and Predicted Target Genes Associated with Environmental Stress in Dendrobium officinale: A Bioinformatics Study
Authors: Hao Li , Zhang Yi
Published: July 2022

Dendrobium officinale (D. officinale) is a widely used traditional Chinese medicine with high economic value. MicroR159 (miR159) is an ancient and conserved microRNA (miRNA) family in land plants, playing roles in the progress of growth and development, as well as the stress response. In order to find out functions of miR159 in D. officinale, multiple bioinformatic approaches were employed and 10 MIR159 genes were found, localizing on seven chromosomes and an unanchored segment of the D. officinale genome. All of the precursor sequences of Dof-miR159 could form a stable stem-loop structure. The phylogenetic analysis revealed that the MIR159 genes of D. officinale were divided into five clades. Furthermore, the conservation analysis suggested that the 2 to 20 nt region of miR159 mature sequences were highly conserved among family members. The promoter analysis of MIR159s showed that the majority of the predicted cis-elements were related to environmental stress or hormones. In total, five classes of genes were predicted to be the target genes of Dof-miR159s, including GAMYB transcription factors, which had been confirmed in many other land plants. The expression patterns of predicted target genes revealed their potential roles in the growth and development of D. officinale, as well as in cold and drought stress responses. In conclusion, our results illustrated the stress-related miR159-targeted genes in D. officinale, which could provide candidate genes for resistance breeding in the future.
Effective Hospital Care Delivery Model for Older People in Nigeria with Multimorbidity: Recommendations for Practice
Authors: Ahmed Abdulsalam , Khan Hafiz T. A. , Lawal Muili
Published: July 2022

The importance of developing an effective action-based model of care for multimorbid patients has become common knowledge, but it remains unclear why researchers in Nigeria have not paid attention to the issue. Hence, this study assessed the quality of health services using the Donabedian model and aimed to recommend an effective hospital care delivery model for older people in Nigeria with multimorbidity. A cross-sectional study using face-to-face data was conducted between October 2021 and February 2022. The reported data were collated, checked, coded, and entered into JISC online survey software and then exported to IBM Statistical Package for Social Science (SPSS) version 27 for analysis, sourced from the University of West London, London, United Kingdom. The data were collected from the outpatient department of four high-volume public secondary hospitals in Niger State (the largest hospital in the three senatorial zones and that of the state capital). Systematic random sampling was used to select 734 patients with two or more chronic diseases (multimorbidity) aged 60 years and above who presented for routine ambulatory outpatient and consented to participate in the study. A Service Availability and Readiness Assessment (SARA) tool was used to assess the structure, and the process quality was assessed by the patients’ experiences as they navigated the care pathway, whereas the outcome was measured using the patients’ overall satisfaction. Using Spearman’s correlation, no statistically significant association was observed between satisfaction level with the healthcare that was received and the five domains of health facility readiness (Total score Basic Amenities, Total score Basic Equipment, Total score infection control, Total score diagnostic capacity, Total score essential drugs), and the general facility readiness. Finally, the process component superseded the structure as the determinant of the quality of healthcare among multimorbid patients in Niger State. The emphasis of the process should be on improving access to quality of care, improving patient–physician relationships and timing, reducing the financial burden of medical care, and building confidence and trust in medical care. Therefore, these factors should be incorporated into designing the healthcare model for multimorbid patients in Nigeria.
Where Is the Artificial Intelligence Applied in Dentistry? Systematic Review and Literature Analysis
Authors: Thurzo Andrej , Urbanová Wanda , Novák Bohuslav , Czako Ladislav , Siebert Tomáš , Stano Peter , Mareková Simona , Fountoulaki Georgia , Kosnáčová Helena , Varga Ivan
Published: July 2022

This literature research had two main objectives. The first objective was to quantify how frequently artificial intelligence (AI) was utilized in dental literature from 2011 until 2021. The second objective was to distinguish the focus of such publications; in particular, dental field and topic. The main inclusion criterium was an original article or review in English focused on dental utilization of AI. All other types of publications or non-dental or non-AI-focused were excluded. The information sources were Web of Science, PubMed, Scopus, and Google Scholar, queried on 19 April 2022. The search string was “artificial intelligence” AND (dental OR dentistry OR tooth OR teeth OR dentofacial OR maxillofacial OR orofacial OR orthodontics OR endodontics OR periodontics OR prosthodontics). Following the removal of duplicates, all remaining publications were returned by searches and were screened by three independent operators to minimize the risk of bias. The analysis of 2011–2021 publications identified 4413 records, from which 1497 were finally selected and calculated according to the year of publication. The results confirmed a historically unprecedented boom in AI dental publications, with an average increase of 21.6% per year over the last decade and a 34.9% increase per year over the last 5 years. In the achievement of the second objective, qualitative assessment of dental AI publications since 2021 identified 1717 records, with 497 papers finally selected. The results of this assessment indicated the relative proportions of focal topics, as follows: radiology 26.36%, orthodontics 18.31%, general scope 17.10%, restorative 12.09%, surgery 11.87% and education 5.63%. The review confirms that the current use of artificial intelligence in dentistry is concentrated mainly around the evaluation of digital diagnostic methods, especially radiology; however, its implementation is expected to gradually penetrate all parts of the profession.
Prevalence, Predictors, and Outcomes of Myocardial Injury in Hospitalized COVID-19 Patients—An Observational Retrospective Study
Authors: Patel Ghanshyam , Smith Jeffrey , Baloch Luqman , Affinati Mario , Vasavada Advait , Reddy Shilpa , Jain Shikha , Hassen Gashaw , Araya Michael , Adak Shrestha
Published: July 2022

COVID-19 mainly causes pulmonary manifestation; nonetheless, its systemic inflammatory response involves multiple organs, including the heart. We aimed to evaluate the prevalence, predictors, and outcomes of myocardial injury in hospitalized patients with SARS-CoV-2 infection. Methods and Results: We performed an observational retrospective analysis on patients hospitalized with COVID-19 in a moderate-sized community hospital system. Myocardial injury was defined as highly sensitive troponin T levels in the 99th percentile above the normal upper limit for the respective biological sex. Multivariable logistic regression models were fitted to assess the association between the myocardial-injury and the no-myocardial-injury groups for primary and secondary outcomes. A total of 1632 (49.3% male, 41.7% aged 60–79 years) patients with COVID-19 were included, out of which 312 (19.1%) had a myocardial injury. Patients with myocardial injury were older (36.9% > 80 years) and had higher cardiovascular-related comorbidities than those without. The prevalence of cardiovascular risk factors (78.5% vs. 52.0%) and cardiovascular diseases (78.2% vs. 56.1%) was much higher in the myocardial-injury group. Older age (50–64 years vs. <49 years; OR, 3.67 [1.99–6.74]), Angiotensin Receptor Blockers (ARBs) (OR, 1.44 [1.01–2.05]), Beta-blockers (OR, 2.37 [1.80–3.13]), and cardiovascular comorbidities (OR, 1.49 [1.09–2.05]) were strong predictors of cardiac injury after multivariable adjustment. Myocardial injury was strongly associated with ICU admission (adjusted OR, 1.68 [1.29–2.19]) and longer length of hospital stay (median days, 5 (3, 9) vs. 4 (2, 7)). The results do not show a significant difference in the use of mechanical ventilation (OR, 1.29 [0.87–1.89]) or in-hospital mortality (OR, 1.37 [0.98–1.91]) with respect to myocardial injury. Conclusion: This multicenter retrospective study of nearly 1600 patients revealed the following findings: Myocardial injury was observed in 1 out of 5 patients hospitalized with COVID-19 but was more often clinically insignificant. Patients of age > 65 had very high odds of having elevated troponin levels after adjusting for sex and other illnesses. Pre-existing cardiac diseases and risk factors were robust predictors of cardiac injury after adjusting for age and sex. In the adjusted model, myocardial injury was not associated with the requirement of mechanical ventilation or change in in-hospital mortality.
To Replicate, or Not to Replicate? The Creation, Use, and Dissemination of 3D Models of Human Remains: A Case Study from Portugal
Authors: Alves-Cardoso Francisca , Campanacho Vanessa
Published: July 2022

Advancements in digital technology have conquered a place in cultural heritage. The widespread use of three-dimensional scanners in bioanthropology have increased the production of 3D digital replicas of human bones that are freely distributed online. However, ethical considerations about such 3D models have not reached Portuguese society, making it impossible to assess their societal impact and people’s perception of how these models are created and used. Therefore, Portuguese residents were asked to take part in an online survey. The ratio of male to female participants was 0.5:1 in 312 contributors. The age ranged between 18 and 69 years. The majority had a higher education degree. Only 43% had seen a 3D model, and 43% considered the 3D replicas the same as real bone. Also, 87% would be willing to allow their skeleton and family members to be digitalized after death, and 64% advocated the controlled dissemination of replicas through registration and login and context description association (84%). Overall, the results suggest agreement in disseminating 3D digital replicas of human bones. On a final note, the limited number of participants may be interpreted as a lack of interest in the topic or, more importantly, a low self-assessment of their opinion on the subject.
Size-Controlling Cherry Rootstock Selection Based on Root Anatomical Characteristics
Authors: Narandžić Tijana , Ljubojević Mirjana
Published: July 2022

Over the past few decades, numerous studies investigated the vigor and productivity of fruit species depending on the rootstock on which they were grafted, but the exact size-controlling mechanism itself has not been fully elucidated, nor were the rapid rootstock selection methods defined. Thus, this study aimed to assess the root anatomical characteristics and their influence on the overall ‘Summit’ cherry tree vigor to confirm the size-controlling effect and establish an effective protocol for rapid rootstock selection. Plant material included three cherry species (Prunus cerasus, Prunus fruticosa, and Prunus mahaleb) and interspecific hybrid ‘Gisela 5′ (P. cerasus × Prunus canescens) as a control. The detailed anatomical analysis included root samples with the differentiated secondary structure taken from the sampling depth of 10–15 cm. Roots with percentages of vessels ≈40%, ≈50%, and ≈10% belonging to size-classes ˂700 µm2, 700–2000 μm2, and ˃2000 µm2 (respectively) are presumed to provide optimal amounts of water solution to the scion, without compromising plant vitality, drought tolerance, and size-controlling effect. Statistically significant correlations were determined between anatomical properties (the percentage of vessels, especially ˃2000 µm2, xylem porosity, and hydraulic conductivity, both per mm2 and total root) and vegetative growth in the juvenile vegetative phase, indicating direct vessel size influence on plant vigor and its employment in size-controlling cherry rootstock selection.
Less Is More? Field Evaluation of Short-Stature Banana Cultivars in a Mediterranean Environment
Authors: Elingold Idan , Londener Avishi , Rimmer Amit , Tsarfaty Avi , Hadar Gilad , ‘Galpaz Navot
Published: July 2022

The shift to cultivation of banana (‘Musa (AAA) Cavendish subgroup’) in screenhouses in Israel has resulted in a significant increase in plant height and, consequently, increased maintenance costs. Here, we evaluated the genetic approach to reducing plantation height. Advanced selections of the local cultivars ‘Adi’, ‘Zelig’, and ‘Gal’, selected for reduced height, were evaluated in the field. Growth and yield parameters were recorded and compared with the industry standard cv. ‘Grand Naine’ for four crop cycles. ‘Adi’ and ‘Zelig’ were shorter than ‘Grand Naine’, by 20% and 10%, respectively, whereas ‘Gal’ lost its short stature over the years. In addition, leaf area was reduced in the low-stature cultivars. Cumulative yield of ‘Adi’ and ‘Zelig’ was higher than that of ‘Grand Naine’, by 8.8% for ‘Adi’ and 5.0% for ‘Zelig’, due to higher plant density and number of harvested bunches. This multiyear study highlights ‘Adi’ and ‘Zelig’ as short-stature, highly productive cultivars with the potential for improved water-use efficiency.
Human Health Benefits through Daily Consumption of Jerusalem Artichoke (Helianthus tuberosus L.) Tubers
Authors: Méndez-Yáñez Angela , Ramos Patricio , Morales-Quintana Luis
Published: July 2022

“Let food be thy medicine and medicine be thy food”, is one of the most famous phrases attributed to Hippocrates, the father of medicine. Scientific research on superfoods has increased in the last six years. These foods have nutritional and pharmacological properties, such that they can help to fight against diseases and poor nutritional status. Helianthus tuberosus L., or Jerusalem artichoke, appears to be a superfood that provides benefits to human health at the level of the digestive, gastrointestinal, and dermatological systems, being fit for patients with diabetes mellitus due to its high content of inulin and use in an optimal hypocaloric diet due to its low carbohydrate content. In fact, 5 to 15 g per day is beneficial, with evidence of a prebiotic effect. Unfortunately, its consumption and cultivation are not well known worldwide. For this reason, the present review describes the benefits of H. tuberosus in human health to promote knowledge about its nutritional benefits.
What Counts for the Old and Oldest Old?—An Analysis of Patient Criteria for Choosing a Dentist—Part I: Awareness and Selection Criteria, Infrastructure, and Dental Office Equipment
Authors: Nitschke Ina , von Chlingensperg Richard , Schrock Annett , Hopfenmüller Werner , Jockusch Julia
Published: July 2022

Utilization of a dentist is influenced by many factors. The aim of this study is to present the factors relating to how patients become aware of a dentist, according to which criteria they select the dentist, and which factors in the infrastructure, equipment of dental offices, and human interactions are important for patients. A telephone survey with 466 participants (female 59.9%) in three age groups (ag 1: 35–50 years, ag 2: 70–84 years, ag 3: >85 years) in three German cities was conducted. Data were analyzed with respect to age, gender, and place of residence. Hardly any differences in the selection of the dentist and the selection criteria applied were found between the sexes, the age groups, or the places of residence. Recommendation seems to be the major aspect regarding how patients become aware of or select their dentist (n = 278, 65.6%), while modern technologies, e.g., the internet, play a subordinate role (n = 31, 7.3%). The unimportance of modern technologies increases significantly with the increase in age. As age increases, factors such as infrastructure (e.g., elevator available (ANOVA p < 0.001; Bonferoni correction: significant differences between ag 1 and ag 2 p < 0.001, ag 1 and ag 3 p < 0.001, and ag 2 and ag 3 p = 0.009); accessibility by wheelchair (ANOVA p < 0.001; Bonferoni correction: significant differences between ag 1 and ag 2 p = 0.006; and ag 1 and ag 3 p < 0.001); etc.) and dental office equipment become significantly important and influence the choice of dentist, while the importance of good parking facilities significantly decreased with age (ANOVA p = 0.003; Bonferoni correction: significant differences between ag 1 and ag 3 p = 0.004, and ag 2 and ag 3 p = 0.023). With increasing age, e.g., the importance of a television in the waiting room (ANOVA p = 0.012; Bonferoni correction: significant differences between ag 1 and ag 3 p = 0.014; and ag 2 and ag 3 p = 0.011), a modern waiting room (ANOVA p < 0.001; Bonferoni correction: significant differences between ag 1 and ag 3 p < 0.001; and ag 2 and ag 3 p < 0.001) or the possibility to visualize the oral situation on a screen decreases significantly (ANOVA p < 0.001; Bonferoni correction: significant differences between ag 1 and ag 2 p < 0.001; ag 1 and ag 3 p < 0.001, and ag 2 and ag 3 p < 0.001). If dentists want to welcome and treat older people, they should adapt the accessibility, infrastructure and equipment of their practice to the needs of older people in order to be able to guarantee continuous lifelong dental care regardless of the need for assistance or care.
Evaluating Locational Preference of Urban Activities with the Time-Dependent Accessibility Using Integrated Spatial Economic Models
Authors: Raza Asif , Zhong Ming , Safdar Muhammad
Published: July 2022

In recent years, accessibility has been considered a vital policy objective in the development of a sustainable transportation system. Accessibility can make a significant contribution to quality of life. The accessibility of desirable locations, such as households and commercial locations, is usually underpinned by land use patterns and transportation infrastructure. The accessibility of different activities is largely determined by the spatial distribution of activities and associated transport networks in a metropolitan area. In order to examine how location choice behaviors of urban activities influence urban forms and land use patterns, accessibility has been used extensively to consider the impact of both the spatial distribution of opportunities (e.g., employment or services) and the transport cost of reaching them. However, in most cases, only those static/aggregate accessibility terms that are represented by the “logsum” of all available transport modes have traditionally been used in urban transport planning and modeling analysis. In this study, according to urban activities, several Integrated Spatial Economic (ISE) models i.e., PECAS (Production, Exchange, Consumption, Allocation, System) models were developed to study the relationship between dynamic, Time-Dependent Accessibility (TDA) and the location choice behavior of urban activities in the City of Wuhan, China. The developed models were then used as tools to investigate the impact of dynamic/disaggregate short-term TDA on location choice behaviors of various urban activities such as households and commercial. Regarding the household location choice, the ISE modeling results revealed that urban households living in the downtown area of the City of Wuhan were sensitive to TDA to employment centers, especially during the morning peak time. In addition, commercial services prefer locations that offer a high level of accessibility during off-peak times. Based on the results of this study, it is recommended that planning exercises, such as the development of zoning and the allocation of urban activities and public facilities, pay more attention to dynamic, short-term TDA, which is essential for urban sectors to carry out daily activities, than their static, composite accessibility counterparts.
Services and Amenities Offered by City Hotels within Family Tourism as One of the Factors Guaranteeing Satisfactory Leisure Time
Authors: Siwek Matylda , Kolasińska Anna , Wrześniewski Krzysztof , Zmuda Palka Magdalena
Published: July 2022

Travelling families are interested in urban tourism due to its cognitive and entertainment aspects. Some expectations of parents travelling with children are the same independent of the accommodation location. The purpose of this article is to examine at what level city hotels offer services and amenities within family tourism, how they meet parents’ expectations and whether they adapt offers to children of different ages. Two measurement tools were used for this study. The first one was the authors’ questionnaire addressed to hotel managers. A total of 88 hotels located in Krakow were selected for the study. The survey contained questions on the offers of hotels related to various services and amenities for families with children, which were assigned to one of three groups (24 items): general child-friendly hotel services and amenities, in-room amenities and restaurant amenities. In the second phase of the study, parents of children aged 0–10 years were asked to assess the degree to which the amenities offered by hotels were important for them during the selection of a hotel. In total, 90 surveys were taken into consideration. The tool was designed to examine the needs of parents who have children of different ages, in regard to selected hotel services and amenities (24 items). As in the case of the surveys for hoteliers, the same three groups were created. The research demonstrates that children’s age is the key factor that should lead to the differentiation of the accommodation offer. However, hoteliers largely perceive children as a homogeneous group. In all studied age categories (6) and amenities groups (3), parents’ expectations were higher than the services and amenities offered. No significant differences regarding the category of the hotel or hotel chain membership have been found. The results of the study may provide valuable guidance to hoteliers who wish to attract families with children to urban tourism and adapt their offer to them, thus realising the principle of inclusiveness. They may be also a significant contribution to the literature on the subject, as most published work concerns holiday hotels rather than city hotels.
Diabetic and Hypertensive Disorders Following Miscarriage: A Protocol for Systematic Review and Meta-Analysis
Authors: Foo Damien , Dunne Jennifer , Pereira Gavin , Gebremedhin Amanuel , Duko Bereket , Tessema Gizachew A.
Published: July 2022

(1) Background: Miscarriages occur in approximately 15–25% of all pregnancies. There is limited evidence suggesting an association between history of miscarriage and the development of diabetic and hypertensive disorders in women. This systematic review aims to collate the existing literature and provide up to date epidemiological evidence on the topic. (2) Methods: We will search CINAHL Plus, Ovid/EMBASE, Ovid/MEDLINE, ProQuest, PubMed, Scopus, Web of Science, and Google Scholar, using a combination of medical subject headings, keywords, and search terms, for relevant articles related to the association between miscarriage and the risk of diabetic and hypertensive disorders. Cross-sectional, case–control, nested case–control, case–cohort, and cohort studies published from inception to April 2022 will be included in the search strategy. Three reviewers will independently screen studies and the risk of bias will be assessed using the Joanna Briggs Institute Critical Appraisal tool. Where the data permit, a meta-analysis will be conducted. (3) Results: The results of this systematic review will be submitted to a peer-reviewed journal for publication. (4) Conclusions: The findings of this systematic review will instigate efforts to manage and prevent reproductive, cardiovascular, and metabolic health consequences associated with miscarriages.
The Long-Term Association between Physical Activity and Weight Regain, Metabolic Risk Factors, Quality of Life and Sleep after Bariatric Surgery
Authors: Santos Cláudia , Carvalho Manuel , Oliveira Leandro , Palmeira António , Rodrigues Luís Monteiro , Gregório João
Published: July 2022

Bariatric surgery is currently regarded as a safe and effective long-term procedure for the treatment of obesity and related comorbidities. We analyzed the association between physical activity (PA), weight regain, metabolic risk factors and quality of life in patients submitted to bariatric surgery. This study also aimed to preliminarily assess how physical activity and weight regain may be associated with sleep quality and sedentary behavior. This was an observational study, with retrospective data collection and a cross-sectional survey. Retrospective clinical data were collected from a sample of 84 individuals who had undergone bariatric gastric bypass surgery at least five years prior to the study period in an Integrated Responsibility Center for Obesity and Metabolic Diseases Surgery. The survey, developed from validated questionnaires and applied in telephone interviews, focused on health data, associated comorbidities, quality of life, physical activity, sedentary behavior and sleep. Descriptive and comparative statistics were performed with a 95% confidence level. Bariatric surgery induced a significant weight loss in the first year after surgery. Our analysis also revealed that lower levels of PA were associated with weight regain. Quality of life as well as sleep quality were inversely related to weight regain, as well as sedentary behavior in general. Primary and secondary outcomes of bariatric surgery can be better achieved if the practice of PA could be maintained for consecutive years.
Factors Influencing Self-Confidence and Willingness to Perform Cardiopulmonary Resuscitation among Working Adults—A Quasi-Experimental Study in a Training Environment
Authors: Jaskiewicz Filip , Kowalewski Dawid , Kaniecka Ewa , Kozlowski Remigiusz , Marczak Michal , Timler Dariusz
Published: July 2022

Background: There is a potential relationship between the self-confidence and the willingness of bystanders to undertake resuscitation (CPR) and its training. The current guidelines increasingly focus on both the importance of the human factor and the fact that training programs should increase the willingness of bystanders to undertake resuscitation, which may have a direct impact on improving survival in out-of-hospital cardiac arrest (OHCA). Aim: The objective of the study was to analyze factors influencing the assessment of own skills crucial in basic life support (BLS) and the willingness to provide CPR to individual victims. Methods: A pre-test and post-test quasi-experimental design was used in this study. The data was collected from 4 December 2019 to 3 October 2020 in workplaces, during instructor-led BLS courses. Each intervention (training) consisted of a theoretical and a practical part. The program was focused both on the skills and the human factor. Results: Comparison of pre-test and post-test data concerning self-confidence scores of the ability to recognize OHCA among 967 participants demonstrated a significant difference (respectively, Me = 2.2, IQR [2–3] vs. Me = 3.4, IQR [3–4]; p = 0.000). Additionally, self-assessment scores for the ability to perform proper chest compressions between pre-test and post-test also differed significantly (respectively Me = 2.3, IQR [2–3] vs. Me = 3.3, IQR [3–4]; p = 0.000). A highly significant difference was found in the likelihood of changing the decision in favor of the willingness to undertake CPR for all types of victims, with the greatest difference found in relation to the willingness to conduct resuscitation on strangers (OR = 7.67, 95% CI 5.01–11.73; p < 0.01). Conclusions: Completing hands-on training has a highly significant, beneficial effect on the readiness to undertake resuscitation for all types of victims, strangers in particular. Training programs should place particular emphasis on developing readiness to undertake resuscitation for both those who have never been trained and those who had their last training more than one year ago.
An Intelligent Cardiopulmonary Training System and Adherence to Training Intensity: A Feasibility Study
Authors: Wei Li , Chi Ju-Yang , Chao Jane C.-J. , Lin Yen-Nung
Published: July 2022

Objective: Our aim was to evaluate the feasibility of our developed intelligent cardiopulmonary training system (ICTS) and of the percentage of time spent within the target HR range (%time) as an indicator of adherence to training intensity. Methods: In this noncontrolled trial, nine participants with sedentary lifestyles were recruited from the outpatient rehabilitation department of a teaching hospital. All participants received twelve 30 min sessions of cycling ergometer exercises (5 min warm up, 20 min training phase, and 5 min cool down) with the ICTS three times per week. Training intensity was determined at 60–80% heart rate reserve using cardiopulmonary exercise (CPET) pretests. During training, pedaling resistance was automatically adjusted by the ICTS to keep the user’s heart rate at the predetermined intensity range. Workload-peak and peak oxygen uptake (VO2-peak) were measured during the pretests and post-tests. We recorded the percentage of time spent within the target heart rate range (%time) during the 20 min training phase for each training session as an indicator of adherence. The correlation between %time and gains in VO2-peak was assessed. Results: After 4 weeks of training on the ICTS, workload-peak and VO2-peak significantly improved by 13.6 ± 7.2 w (mean ± SD, p = 0.008) and 1.5 ± 1.1 mL/kg/min (p = 0.011), respectively. The 12-session average %time ranged from 10.6% to 93.1% among the participants, and five participants achieved an average %time >80%. A positive correlation between average %time and training efficacy was found (rs = 0.85, p = 0.004). Conclusions: Cardiopulmonary training with an ICTS is feasible, and the percentage of time spent within the target heart rate range seems to be a reasonable indicator for monitoring training-intensity adherence.
Club Convergence of Economies’ Per Capita Carbon Emissions: Evidence from Countries That Proposed Carbon Neutrality
Authors: Yang Zhaofu , Yuan Yongna , Tan Yu
Published: July 2022

To achieve the long-term goals outlined in the Paris Agreement that address climate change, many countries have committed to carbon neutrality targets. The study of the characteristics and emissions trends of these economies is essential for the realistic formulation of accurate corresponding carbon neutral policies. In this study, we investigate the convergence characteristics of per capita carbon emissions (PCCEs) in 121 countries with carbon neutrality targets from 1990 to 2019 using a nonlinear time-varying factor model-based club convergence analysis, followed by an ordered logit model to explore the mechanism of convergence club formation. The results reveal three relevant findings. (1) Three convergence clubs for the PCCEs of countries with proposed carbon neutrality targets were evident, and the PCCEs of different convergence clubs converged in multiple steady-state levels along differing transition paths. (2) After the Kyoto Protocol came into effect, some developed countries were moved to the club with lower emissions levels, whereas some developing countries displayed elevated emissions, converging with the higher-level club. (3) It was shown that countries with higher initial emissions, energy intensity, industrial structure, and economic development levels are more likely to converge with higher-PCCEs clubs, whereas countries with higher urbanization levels are more likely to converge in clubs with lower PCCEs.
Sacral Neuromodulation in Pregnant Women—A Case Report and Literature Review
Authors: Szymański Jacek K. , Słabuszewska-Jóźwiak Aneta , Jakiel Grzegorz
Published: July 2022

Millions of women around the world suffer from an overactive bladder and urinary retention. A significant number of them are of reproductive age. For 25 years, SNM has been an effective therapy for treatment-resistant hyperactive bladder and idiopathic urinary retention. The paper presents a case of a 35-year-old pregnant woman with an overactive bladder resistant to pharmacological treatment, who responded positively to sacral neuromodulation. The patient decided against deactivating the neuromodulator and, after an uneventful course of pregnancy, she gave birth by a caesarean section to a healthy female infant. The use of SNM in pregnant patients remains a constant clinical challenge. The current literature was reviewed, but published studies do not provide a clear answer. Further studies with a long follow-up period are necessary to determine more accurately the effects of SNM therapy on the fetus and the course of pregnancy. Currently, it is recommended to deactivate SNM during pregnancy. However, it seems that an individual approach to the patient with information on the risks and benefits of continuing or discontinuing therapy should be the current procedure.
Knowledge Domain and Emerging Trends of Social Vulnerability Research: A Bibliometric Analysis (1991–2021)
Authors: Li Hua , Wang Weijun
Published: July 2022

Carrying out social vulnerability research has become an important way to understand the sustainable development of resources, the environment, populations, and societies. Clarifying the research context and development trend of social vulnerability is of great significance to the follow-up theoretical research on and practical exploration of sustainable social development. With the help of a CiteSpace knowledge map analysis, this study reveals the research hotspots and their evolution in different periods and puts forward the key problems in and future direction of social vulnerability research in the future. This study found that the number of articles on social vulnerability research showed a steady upward trend and that the research experienced roughly three stages: an embryonic stage, a development stage, and a stable stage. The United States, Brazil, the United Kingdom, and China accounted for the majority of the research, but the intensity of cooperation between them is still weak. Vulnerability assessment and risk assessment in the context of policy and environmental change are hot topics in the current research. In the future, it is necessary to focus on the comprehensive research on the integrated and cross-scale research on social vulnerability, research on its occurrence and evolution, and on the dynamic monitoring as well as optimal regulation of social vulnerability under multiple pressures.
Physical Activity in Pulmonary Arterial Hypertension during Pandemic COVID-19 and the Potential Impact of Mental Factors
Authors: Wieteska-Miłek Maria , Szmit Sebastian , Florczyk Michał , Witowicz Anna , Kurzyna Marcin
Published: July 2022

One of the non-pharmacological recommendations for stable patients with pulmonary arterial hypertension (PAH) is to increase physical activity. The study aimed to analyze the degree of physical activity of PAH patients and check if mental factors may have a potential negative impact during the COVID-19 pandemic. Forty patients with stable PAH were included in the study. Physical activity was assessed by pedometer (Omron HJ-321-E) for four weeks. At baseline, in addition to the 6 min walk test (6MWT) and functional assessment, patients completed the quality-of-life questionnaire SF-36, fear of COVID-19 scale, and hospital anxiety and depression scale (HADS). The mean age of the study group was 45.5 years, 80% were women, and 62.5% had idiopathic/heritable PAH. Low physical activity defined as <5000 steps/day had 19 (47.5%), and moderate/high physical activity (≥5000 steps/day) had 21 (52.5%) patients. Patients with low physical activity less frequently worked compared with the moderate–high-activity sub-group, 42% vs. 81%, p = 0.03, and had the shorter distance in 6-6MWT, p = 0.03. There was no significant correlation between steps/day and different mental factors. Almost half of the study group had low activity during the pandemic. Mental factors did not impact physical activity in PAH patients during the pandemic.
Assessment of Physical Well-Being and Leisure Time of Polish Students during the COVID-19 Outbreak
Authors: Jaskulska Sylwia , Jankowiak Barbara , Marciniak Mateusz , Klichowski Michal
Published: July 2022

This project aims to recognize the school experiences of Polish students during the COVID-19 outbreak; we focused on the area of assessment of physical well-being and leisure time. Nearly two thousand primary or secondary school students aged 9 to 20 participated in the survey. Running descriptive statistics, frequency analysis, and significant difference tests, we found that 45% of students thought their physical well-being during the COVID-19 outbreak worsened compared to pre-pandemic times. Boys declared they felt better in their physical well-being than girls (p < 0.001). Most students noticed changes in the quality of their leisure time activities; boys were happier than girls in their free time during the outbreak (p < 0.001). Learners’ ages also differentiated the assessment of their physical well-being (p < 0.001) and leisure time (p < 0.001). The youngest students more often assessed their experiences in the researched fields as good or increased, while the older groups more often noticed a decrease. Multinomial logistic regression proved that the differences in the assessments of physical well-being and leisure time could be explained to the greatest extent by age and gender, whereas the place of residence and school location were insignificant. All in all, our study confirms the dominance of the adverse effects of the COVID-19 pandemic on physical well-being and changes in leisure time. As such, it is advisable (during and after outbreaks) to support children and adolescents by targeting individual and institution levels. We recommend developing techniques to reduce stress and information overload, increasing creative ways of spending leisure time, supporting families in navigating children’s free time, and expanding social support networks.
In Silico Approach in the Evaluation of Pro-Inflammatory Potential of Polycyclic Aromatic Hydrocarbons and Volatile Organic Compounds through Binding Affinity to the Human Toll-Like Receptor 4
Authors: Cabral Marie Beatriz , Dela Cruz Celine Joy , Sato Yumika , Oyong Glenn , Rempillo Ofelia , Galvez Maria Cecilia , Vallar Edgar
Published: July 2022

Polycyclic aromatic hydrocarbons (PAHs) and volatile organic compounds (VOCs) are widespread across the globe, existing in the environment in complex mixtures potentially capable of initiating respiratory illnesses. Here, we use an in silico approach to evaluate the potential pro-inflammatory effects of various carcinogenic PAHs and VOCs through their binding affinity towards the human toll-like receptor 4 (TLR4). For receptors and ligands, RCSB Protein Data Bank and PubChem were used in obtaining their 3D structures, respectively. Autodock Vina was utilized to obtain the best docking poses and binding affinities of each PAH and VOC. Out of the 14 PAHs included in this study, indeno(1,2,3-cd)pyrene, benzo(ghi)perylene, and benzo[a]pyrene had the highest binding affinity values of −10, −9, and −8.9 kcal/mol, respectively. For the VOCs, out of the 10 compounds studied, benzene, 1,4-dichlorobenzene, and styrene had the highest binding affinity values of −3.6, −3.9, and −4.6 kcal/mol, respectively. Compounds with higher affinity than LPS (−4.1 kcal/com) could potentially induce inflammation, while compounds with lower affinity would be less likely to induce an inflammatory response. Meanwhile, molecular dynamics simulation and RMSF statistical analysis proved that the protein, TLR4, stably preserve its conformation despite ligand interactions. Overall, the structure of the TLR4 was considered inflexible.
Thyroid Diseases and Chronic Rhinosinusitis: A Nested Case–Control Study Using a National Health Screening Cohort
Authors: Choi Hyo Geun , Kim Tae Jun , Hong Sung Kwang , Min Chanyang , Yoo Dae Myoung , Kim Heejin , Lee Joong Seob
Published: July 2022

This study aimed to investigate the association between thyroid diseases and chronic sinusitis (CRS) in a matched cohort in a study conducted within the Korean National Health Insurance Service-Health Screening Cohort (2002–2015). A total of 6024 patients with CRS were 1:4-matched for age, sex, household income, and region of residence with 24,096 control participants. Effects of a previous history of thyroid disease, including hypothyroidism, hyperthyroidism, thyroiditis, autoimmune thyroiditis, and Graves’ disease, were investigated using conditional logistic regression. Subgroup analyses were performed in regard to the presence of nasal polyposis. A history of hypothyroidism (2.8% vs. 1.8%), hyperthyroidism (2.0% vs. 1.5%), thyroiditis (1.1% vs. 0.8%), autoimmune thyroiditis (0.4% vs. 0.3%), and Graves’ disease (0.3% vs. 0.2%) was not more prevalent in the CRS group than in the control group according to univariate analysis (all p > 0.05). Hypothyroidism was associated with CRS in the multivariate-adjusted model (odds ratio [OR] 1.25, 95% confidence interval [CI] 1.00–1.57). In the subgroup analyses, thyroid diseases were not statistically significantly associated with CRS after being classified according to the presence or absence of nasal polyps. Additional studies are required to elucidate the relationship between thyroid diseases and CRS, as this may aid in screening and clinical decision making.
Reliability and Validity of Common Subjective Instruments in Assessing Physical Activity and Sedentary Behaviour in Chinese College Students
Authors: Gao Hui , Li Xingxing , Zi Yunhua , Mu Xuanwen , Fu Mingjian , Mo Tingting , Yu Kuai
Published: July 2022

The reliability and validity of common physical activity (PA) questionnaires are not well investigated in college students. This study aims to evaluate the reliability and validity of common subjective instruments in measuring PA and sedentary behaviour (SB) among college students. A total of 142 college students were included through convenience sampling. Each participant was asked to wear Actigraph wGT3X-BT accelerometers and fill physical activity logs (PAL) for 7 consecutive days. The Global Physical Activity Questionnaire (GPAQ), the International Physical Activity Questionnaire long-form (IPAQ-LF), and short-form (IPAQ-SF) were interviewed by face-to-face at both day 0 and day 8. Reliability was evaluated by intraclass correlation coefficient (ICC), while the validity was evaluated by Spearman correlation coefficient and Bland–Altman statistics. The instruments showed moderate reliability in reporting total PA (ICC = 0.50–0.62) and SB (ICC = 0.47–0.52), while moderate validity in reporting moderate and vigorous PA (MVPA) (r = 0.37–0.42), but fair to poor validity in reporting SB (r = 0.09–0.28). Bland–Altman plots showed that all the instruments would underestimate MVPA and overestimate SB. Thus, in Chinese younger adults, the GPAQ, IPAQ-LF, IPAQ-SF, and PAL provide limited but acceptable reliability and validity in measuring MVPA and SB, among which GPAQ might be the most valid instrument.
Spatial Distribution of Soil Heavy Metals and Associated Environmental Risks near Major Roads in Southern Tibet, China
Authors: She Wanjiang , Guo Linghui , Gao Jiangbo , Zhang Chi , Wu Shaohong , Jiao Yuanmei , Zhu Gaoru
Published: July 2022

Soil heavy metal pollution is becoming an increasingly serious environmental problem. This study was performed to investigate the contents of surface soil heavy metals (Cu, Zn, Pb, Cd) near six roads in the southern part of the Tibetan Plateau. Multivariate statistics, geoaccumulation index, potential ecological risk, and a human health assessment model were used to study the spatial pollution pattern and identify the main pollutants and regions of concern. The mean Igeo was ranked in the order Cd > Cu > Zn > Pb, with the average concentrations of Cd, Zn, and Cu exceeding their corresponding background levels 4.36-, 1.00-, and 1.8-fold, respectively. Soil Cd level was classified as posing a considerable potential risk near national highways and a high potential risk near non-national highways, whereas soil Cu, Zn, and Pb were associated with a low potential ecological risk for each class of roads. Furthermore, the non-carcinogenic risk due to soil heavy metals for each class of roads was within the acceptable risk level for three exposure pathways for both adults and children, but the carcinogenic risk attributable to soil Pb exceeded the threshold for children near highways G318, G562, and G219 and for adults near highway G318. Our work not only underscores the importance of assessing potential threats to ecological and human health due to soil heavy metal pollution on road surfaces but also provides quantitative guidance for remediation actions.
Into the “New Normal”: The Ethical and Analytical Challenge Facing Public Health Post-COVID-19
Authors: Boas Hagai , Davidovitch Nadav
Published: July 2022

Even though various countries’ overall policy for dealing with the pandemic was not particularly innovative, the pandemic was perceived as a unique crisis. “COVID exceptionalism” has seemed to create “a new normal” that we all need to “learn to live with”. The main change in perspective, while not new for public health experts, is that health exists within a social and political context. While public health ethics has turned out to be an important discipline, there is a long way to its wider acceptance. Entering the “new normal” calls for a wider embrace of public health approaches to ethics. The renewed emphasis on understanding health as a social concept encompasses central normative implications in relation to dealing with COVID-19 and in relation to dealing with other global crises, chiefly climate change. We argue that entering the era of “the new normal” in healthcare requires a nuanced understanding of the relationship between the individual and society and demands the formulation of a new system of bioethics focused on the concept of solidarity as a central value in public health. Such a concept should refer to the fact that in the “new normal”, risks require new social and political formations of standing together in confronting risks that cross national, cultural, and identity borders. Forming and expanding solidarity in health and healthcare, we argue, is the main normative challenge for public health today.
Innate Immunity Crosstalk with Helicobacter pylori: Pattern Recognition Receptors and Cellular Responses
Authors: Cheok Yi Ying , Tan Grace Min Yi , Lee Chalystha Yie Qin , Abdullah Suhailah , Looi Chung Yeng , Wong Won Fen
Published: July 2022

Helicobacter pylori is one of the most successful gastric pathogens that has co-existed with human for centuries. H. pylori is recognized by the host immune system through human pattern recognition receptors (PRRs), such as toll-like receptors (TLRs), C-type lectin like receptors (CLRs), NOD-like receptors (NLRs), and RIG-I-like receptors (RLRs), which activate downstream signaling pathways. Following bacterial recognition, the first responders of the innate immune system, including neutrophils, macrophages, and dendritic cells, eradicate the bacteria through phagocytic and inflammatory reaction. This review provides current understanding of the interaction between the innate arm of host immunity and H. pylori, by summarizing H. pylori recognition by PRRs, and the subsequent signaling pathway activation in host innate immune cells.