bluuebunny/crossref_metadata_2025 huggingface dataset:
Conclusions
Authors: Eleonorasdotter Emma
Published: December 2023

The women who were interviewed for this book have shown that the use of drugs can be very different from stereotypical representations. Many accounts of the women’s gendered use of drugs are, for example, remarkably calm; their adventures involving drug use take place internally and can be pursued in relation to, rather than deviating from, the surrounding society. I argue that the findings of variety and the women’s thought-provoking motives and considerations regarding drug use, which have been discussed throughout this book, highlight the discrepancy between drug use as a seemingly fixed and delimited problem, and the multitude of meanings and uses that it can actually have. This book calls for an intersectional revision of what drug use is, and how problems regarding drugs should be tackled, that takes social, material and cultural conditions into account. The world is not drug-free, and the changes of perspective in drug use, as well as the risks, depend upon the point in the world where that drug use takes place.
Behaving with Children
Authors: Eleonorasdotter Emma
Published: December 2023

In many ways, children were perceived by the women as the symbolic counterparts of drugs. This also makes drug-affected bodies the symbolic counterparts of children. In this chapter, I explore this charged relationship between women who use drugs and children, who are traditionally women’s responsibility to look after. The women describe various strategies for taking responsibility, for both symbolic and real-life children. This is achieved through various and opposing strategies; through the use of drugs, through spatial separation between children and drugs, through talking to children about drugs or through telling them as little as possible.
Negotiating Addiction
Authors: Eleonorasdotter Emma
Published: December 2023

This chapter examines the meanings of addiction from a phenomenological perspective, using Sara Ahmed’s concept of lines in relation to the makings of class. How can the relationship between fear of addiction and the desire to use certain drugs but not others be understood? The women’s experiences of pleasure as crucial to the development of addiction are explored, as well as the relationship between addiction and middle-class ideals of self-actualisation and development.
A simple tool for evaluation of inflammation in psoriasis: Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio as markers in psoriasis patients and related murine models of psoriasis-like skin disease
Authors: Kommoss Katharina S. , Bieler Tabea , Ringen Julia , Lehmann Annika , Mihalceanu Silvia , Hobohm Lukas , Keller Karsten , Brand Anna , Fischer Berenice , Kramer Daniela , Wild Johannes , Waisman Ari , Enk Alexander , Schäkel Knut , Heikenwälder Mathias , Karbach Susanne
Published: December 2023

Objective parameters to quantify psoriatic inflammation are needed for interdisciplinary patient care, as well as preclinical experimental models. This study evaluates neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in psoriasis patients and five murine models of psoriasis-like skin disease based on topical imiquimod application and overexpression of IL-17A under different promotors. We performed a single-center prospective observational study in a German population, investigating psoriasis patients prior to, 4 weeks, and 16 weeks post begin of systemic anti-inflammatory therapy. Psoriasis area and severity index (PASI), blood count, and C-reactive protein (CRP) levels were attained at each timepoint. Additionally, five murine models of psoriasis-like skin disease involving five distinct experimental procedures differing in time of disease-onset and severity were investigated regarding PLR and NLR. Of 43 recruited psoriasis patients, 34 patients were followed up to 16 weeks. The cohort was 69.77% male, showing a median age of 32.0 years (range 19.0–67.0; IQR 26). The median PASI decreased from 16.35 (8.0–50.0; 10.20) to 1.6 (0–10.3; 2.56) after 16 weeks of systemic therapy. Spearman’s correlation showed statistically significant positive correlation for NLR with PASI (rs = 0.27, p = 0.006), however not for PLR. NLR, but not PLR, was significantly associated with PASI in a multiple linear regression analysis including age, sex, psoriasis arthritis, and smoking. In the murine models of psoriasis-like skin disease, both NLR and PLR were significantly increased in the acute-severe models compared to controls (p < 0.001, p = 0.005, and p = 0.02, respectively), demonstrating gradually less increased values from severe-acute to mild-late-onset psoriatic phenotype. NLR was significantly associated with PASI in psoriatic patients as well as psoriatic phenotype in different murine psoriasis models. Our data warrants investigation of NLR in psoriasis patients and preclinical psoriasis models as an objective biomarker of psoriatic skin inflammation.

Key messages

NLR, but not PLR, showed a statistically significant positive correlation with Psoriasis Area and Severity Index (PASI) in our human psoriasis cohort.

Both NLR and PLR were significantly increased in murine psoriasis models compared to matched controls, with gradually less increased values from severe-acute to mild-late-onset psoriatic phenotype.

NLR may represent an easily available, cheap, and objective parameter to monitor psoriatic inflammation in both clinical patient routine, as well as preclinical experimental murine models.
Mineralocorticoid receptor overactivation: targeting systemic impact with non-steroidal mineralocorticoid receptor antagonists
Authors: Savarese Gianluigi , Lindberg Felix , Filippatos Gerasimos , Butler Javed , Anker Stefan D.
Published: December 2023

The overactivation of the mineralocorticoid receptor (MR) promotes pathophysiological processes related to multiple physiological systems, including the heart, vasculature, adipose tissue and kidneys. The inhibition of the MR with classical MR antagonists (MRA) has successfully improved outcomes most evidently in heart failure. However, real and perceived risk of side effects and limited tolerability associated with classical MRA have represented barriers to implementing MRA in settings where they have been already proven efficacious (heart failure with reduced ejection fraction) and studying their potential role in settings where they might be beneficial but where risk of safety events is perceived to be higher (renal disease). Novel non-steroidal MRA have distinct properties that might translate into favourable clinical effects and better safety profiles as compared with MRA currently used in clinical practice. Randomised trials have shown benefits of non-steroidal MRA in a range of clinical contexts, including diabetic kidney disease, hypertension and heart failure. This review provides an overview of the literature on the systemic impact of MR overactivation across organ systems. Moreover, we summarise the evidence from preclinical studies and clinical trials that have set the stage for a potential new paradigm of MR antagonism.

Graphical Abstract
Optimisation of process parameters for improving surface quality in laser powder bed fusion
Authors: Qin Yuchu , Lou Shan , Shi Peizhi , Qi Qunfen , Zeng Wenhan , Scott Paul J. , Jiang Xiangqian
Published: December 2023

Surface quality is one of the critical factors that affect the performance of a laser powder bed fusion part. Optimising process parameters in process design is an important way to improve surface quality. So far, a number of optimisation methods have been presented within academia. Each of these methods can work well in its specific context. But they were established on a few special surfaces and may not be capable to produce satisfying results for an arbitrary part. Besides, they do not consider the simultaneous improvement of the quality of multiple critical surfaces of a part. In this paper, an approach for optimising process parameters to improve the surface quality of laser powder bed fusion parts is proposed. Firstly, Taguchi optimisation is performed to generate a small number of alternative combinations of the process parameters to be optimised. Then, actual build and measurement experiments are conducted to obtain the quality indicator values of a certain number of critical surfaces under each alternative combination. After that, a flexible three-way technique for order of preference by similarity to ideal solution is used to determine the optimal combination of process parameters from the generated alternatives. Finally, a case study is presented to demonstrate the proposed approach. The demonstration results show that the proposed approach only needs a small amount of experimental data and takes into account the simultaneous improvement of the quality of multiple critical surfaces of an arbitrary part.
Functionality of the Na+-translocating NADH:quinone oxidoreductase and quinol:fumarate reductase from Prevotella bryantii inferred from homology modeling
Authors: Hau Jann-Louis , Schleicher Lena , Herdan Sebastian , Simon Jörg , Seifert Jana , Fritz Günter , Steuber Julia
Published: December 2023

Members of the family Prevotellaceae are Gram-negative, obligate anaerobic bacteria found in animal and human microbiota. In Prevotella bryantii, the Na+-translocating NADH:quinone oxidoreductase (NQR) and quinol:fumarate reductase (QFR) interact using menaquinone as electron carrier, catalyzing NADH:fumarate oxidoreduction. P. bryantii NQR establishes a sodium-motive force, whereas P. bryantii QFR does not contribute to membrane energization. To elucidate the possible mode of function, we present 3D structural models of NQR and QFR from P. bryantii to predict cofactor-binding sites, electron transfer routes and interaction with substrates. Molecular docking reveals the proposed mode of menaquinone binding to the quinone site of subunit NqrB of P. bryantii NQR. A comparison of the 3D model of P. bryantii QFR with experimentally determined structures suggests alternative pathways for transmembrane proton transport in this type of QFR. Our findings are relevant for NADH-dependent succinate formation in anaerobic bacteria which operate both NQR and QFR.
Reduction of malic acid in bilberry juice by Lactiplantibacillus plantarum-mediated malolactic fermentation
Authors: Bergentall Martina K. , Malafronte Loredana , As Dorine , Calmet Emeline , Melin Petter
Published: December 2023

Bilberries (Vaccinium myrtillus) are the most common wild berries in Northern Europe. A substantial amount of the berries are picked with the objective to extract highly valued products such as anthocyanins. A smaller amount of the bilberries is used to make jams and drinks, and these are generally restricted to the domestic market. One reason is the sour taste, partly as a result of the high content of malic acid. By using certain strains of lactic acid bacteria with the ability to convert malic acid to lactic acid, the taste is predicted to be more pleasant. This process is called malolactic fermentation, and historically it has mostly been used in winemaking. After testing five different starter cultures, we identified that the strain, Lactiplantibacillus plantarum LP58, can rapidly convert malic acid to lactic acid without any loss of sugar or citric acid, which strongly indicates a successful malolactic acid fermentation. As it has been reported that other strains of L. plantarum can be used as biopreservative agents, the resulting product was also tested in terms of microbial safety after prolonged storage, and by means of metagenome sequencing. The obtained product was quite tolerant to microbial growth, but this observation was rather due to an initial heat treatment than the addition of lactobacilli. Potentially, starter cultures with documented biopreservative activity can be combined with L. plantarum LP58 to obtain a more stable product. Until then, the fermented bilberry juice must be processed and preserved like non-fermented bilberry products.
Quick, Safe, Effective: Ultrasound-Guided Percutaneous Liver Biopsy in the Pediatric Patient
Authors: Salamo Russell M. , Miller Joseph
Published: December 2023

Background

Percutaneous liver biopsy has proven to be a valuable tool in the workup of pediatric acute liver failure and the management of post-transplant rejection. However, consensus regarding pre-procedure laboratory values and post-procedure monitoring is lacking.

Objective

To characterize the incidence of complications, procedural time, and specimen adequacy for percutaneous liver biopsy in the pediatric patient.

Methods

Retrospective review of percutaneous liver biopsies at a single institution was performed for a 5-year span. Procedural notes and anesthesia records were sampled for patient weight and procedural factors across a continuous 6-month period, as well as for the subgroup of patients under 24 months of age. A representative continuous subset of pathology reports comprising 376 patients were reviewed for estimation of specimen adequacy.

Results

Eight hundred and sixty-seven ultrasound-guided percutaneous liver biopsies were performed in a 5-year period, 450 of which were in the post-transplant setting with about a 3:1 ratio of split: whole liver transplant. Patient ages ranged from 1 month to 21 years old, with weight ranging from 2.7 to 125 kg. Of the 376 pathology reports available, none were found to be inadequate for evaluation. Two major complications occurred, both of which were biliary leaks in the setting split-liver transplant. There were no incidences of post-procedure hemorrhage. Of the sample reviewed, mean “skin-to-skin” procedure time was under 8.5 min (median of 7 min). Solely among transplant patients, biopsies for split livers averaged 9.2 min, biopsies for whole livers averaged 6.2 min (two-tailed independent t test, p = 0.0426).

Conclusion

Ultrasound guided percutaneous liver biopsy is fast, useful, and safe in pediatric patients on an outpatient basis with same day discharge.

Level of Evidence IV

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
Evidence mapping on how to perform an optimal surgical repair of large hiatal hernias
Authors: Nickel Felix , Müller Philip C. , Cizmic Amila , Häberle Frida , Muller Markus K. , Billeter Adrian T. , Linke Georg R. , Mann Oliver , Hackert Thilo , Gutschow Christian A. , Müller-Stich Beat P.
Published: December 2023

Background

Symptomatic and large hiatal hernia (HH) is a common disorder requiring surgical management. However, there is a lack of systematic, evidence-based recommendations summarizing recent reviews on surgical treatment of symptomatic HH. Therefore, this systematic review aimed to create evidence mapping on the key technical issues of HH repair based on the highest available evidence.

Methods

A systematic review identified studies on eight key issues of large symptomatic HH repair. The literature was screened for the highest level of evidence (LE from level 1 to 5) according to the Oxford Center for evidence-based medicine’s scale. For each topic, only studies of the highest available level of evidence were considered.

Results

Out of the 28.783 studies matching the keyword algorithm, 47 were considered. The following recommendations could be deduced: minimally invasive surgery is the recommended approach (LE 1a); a complete hernia sac dissection should be considered (LE 3b); extensive division of short gastric vessels cannot be recommended; however, limited dissection of the most upper vessels may be helpful for a floppy fundoplication (LE 1a); vagus nerve should be preserved (LE 3b); a dorso-ventral cruroplasty is recommended (LE 1b); routine fundoplication should be considered to prevent postoperative gastroesophageal reflux (LE 2b); posterior partial fundoplication should be favored over other forms of fundoplication (LE 1a); mesh augmentation is indicated in large HH with paraesophageal involvement (LE 1a).

Conclusion

The current evidence mapping is a reasonable instrument based on the best evidence available to guide surgeons in determining optimal symptomatic and large HH repair.
Therapeutische Eigenanteile in der Gegenübertragung
Authors: Berger J. A. , Kästner D. , Gumz A.
Published: December 2023

Gegenübertragung (GÜ) gilt mittlerweile als eines der wichtigsten Werkzeuge psychodynamischer Verfahren. Während die interpersonellen Muster des/r Patient:in, die sich in dieser wiederfinden, praktisch und theoretisch vielfach beachtet werden, ist noch wenig über die Eigenanteile des/r Therapeut:in in der GÜ bekannt. Eine Schwierigkeit in der Beforschung dieser besteht in der Erfassung eines Phänomens, das viele Forscher:innen als ich-synton und damit unbewusst begreifen. Eine Annäherung an das Thema erfolgte bisher überwiegend durch Fallberichte klinisch tätiger Autor:innen. Der vorliegende Beitrag bietet einen Überblick über die bisherige empirische Forschung zu dem Thema.

Die systematische Suche erfolgte über die elektronischen Datenbanken PsycINFO, PsycArticles, PubMed und PSYNDEX und bezog nach Titel- und Abstractscreening von 1037 Studien schließlich 10 Publikationen in die Auswertung ein. Dabei wurde deutlich, dass die eingeschlossenen Studien sowohl hinsichtlich der zugrunde liegenden Definitionen von Eigenanteil und GÜ sowie der Versuche, diese messbar zu machen, stark divergieren.

Um Eigenanteile im Kontext des GÜ-Geschehens zu erfassen, wird eine Erweiterung des Konzeptes von Hayes vorgeschlagen, das folgende Therapeut:innenanteile integriert: Persönlichkeitseigenschaften und Einstellungen, soziodemografische Merkmale und biografische Erfahrungen (subjektive Einschätzungen versus objektive Informationen).
Kidney biopsy findings in children with diabetes mellitus
Authors: Weerasooriya Lasanthi , Howie Alexander J. , Wakeman Matthew P. , Cavanagh Susan , Milford David V.
Published: December 2023

Background

Diabetic nephropathy may begin in childhood, but clinical kidney disease ascribable to this is uncommon in children with type 1 (insulin dependent) diabetes mellitus.

Methods

We reviewed our experience of kidney biopsies in children with type 1 diabetes mellitus.

Results

Between 1995 and 2022, there were biopsies in 17 children, with various clinical indications for kidney biopsy, making this the largest series of biopsies in diabetic children with clinical kidney abnormalities. Four biopsies showed diabetic nephropathy, three showed the combination of diabetic nephropathy and IgA nephropathy, and ten showed a variety of conditions other than diabetic nephropathy: minimal change disease (2), membranous nephropathy (2), thin glomerular basement membrane lesion (2), non-glomerular chronic damage in Wolcott–Rallison syndrome (2), acute pauciimmune necrotizing crescentic glomerulonephritis (1) and IgA nephropathy (1). Clinical clues of something other than diabetic nephropathy included acute kidney injury, microscopic haematuria or chronic kidney impairment with little or no proteinuria and the nephrotic syndrome after a short duration of diabetes.

Conclusions

We confirm that changes better known in adults with either type 1 or type 2 diabetes mellitus can occur in children with type 1 diabetes mellitus: overt diabetic nephropathy either on its own or combined with other conditions and kidney disorders other than diabetic nephropathy.

Graphical abstract
2023 updated MASCC/ESMO consensus recommendations: prevention of nausea and vomiting following high-emetic-risk antineoplastic agents
Authors: Herrstedt Jørn , Celio L , Hesketh PJ , Zhang L , Navari R , Chan A , Saito M , Chow R , Aapro M
Published: December 2023

Purpose

This systematic review updates the MASCC/ESMO recommendations for high-emetic-risk chemotherapy (HEC) published in 2016–2017. HEC still includes cisplatin, carmustine, dacarbazine, mechlorethamine, streptozocin, and cyclophosphamide in doses of > 1500 mg/m2 and the combination of cyclophosphamide and an anthracycline (AC) in women with breast cancer.

Methods

A systematic review report following the PRISMA guidelines of the literature from January 1, 2015, until February 1, 2023, was performed. PubMed (Ovid), Scopus (Google), and the Cochrane Database of Systematic Reviews were searched. The literature search was limited to randomized controlled trials, systematic reviews, and meta-analyses.

Results

Forty-six new references were determined to be relevant. The main topics identified were (1) steroid-sparing regimens, (2) olanzapine-containing regimens, and (3) other issues such as comparisons of antiemetics of the same drug class, intravenous NK1 receptor antagonists, and potentially new antiemetics. Five updated recommendations are presented.

Conclusion

There is no need to prescribe steroids (dexamethasone) beyond day 1 after AC HEC, whereas a 4-day regimen is recommended in non-AC HEC. Olanzapine is now recommended as a fixed part of a four-drug prophylactic antiemetic regimen in both non-AC and AC HEC. No major differences between 5-HT3 receptor antagonists or between NK1 receptor antagonists were identified. No new antiemetic agents qualified for inclusion in the updated recommendations.
Locally harmonic Maass forms of positive even weight
Authors: Mono Andreas
Published: December 2023

We twist Zagier’s function fk,D by a sign function and a genus character. Assuming weight 0 < k ≡ 2 (mod 4), and letting D be a positive non-square discriminant, we prove that the obstruction to modularity caused by the sign function can be corrected obtaining a locally harmonic Maaß form or a local cusp form of the same weight. In addition, we provide an alternative representation of our new function in terms of a twisted trace of modular cycle integrals of a Poincaré series due to Petersson.
On the packing/covering conjecture of infinite matroids
Authors: Joó Attila
Published: December 2023

The Packing/Covering Conjecture was introduced by Bowler and Carmesin motivated by the Matroid Partition Theorem of Edmonds and Fulkerson. A packing for a family $$({M_i}:i \in \Theta)$$
(

M
i

:
i
∈
Θ
)
of matroids on the common edge set E is a system $$({S_i}:i \in \Theta)$$
(

S
i

:
i
∈
Θ
)
of pairwise disjoint subsets of E where Si is panning in Mi. Similarly, a covering is a system (Ii: i ∈ Θ) with $${\cup _{i \in \Theta}}{I_i} = E$$

∪

i
∈
Θ

I
i

=
E
where Ii is independent in Mi. The conjecture states that for every matroid family on E there is a partition $$E = {E_p} \sqcup {E_c}$$
E
=

E
p

⊔

E
c

such that $$({M_i}\upharpoonright{E_p}:i \in \Theta)$$
(

M
i

↾

E
p

:
i
∈
Θ
)
admits a packing and $$({M_i}.{E_c}:i \in \Theta)$$
(

M
i

.

E
c

:
i
∈
Θ
)
admits a covering. We prove the case where E is countable and each Mi is either finitary or cofinitary. To do so, we give a common generalisation of the singular matroid intersection theorem of Ghaderi and the countable case of the Matroid Intersection Conjecture by Nash-Williams by showing that the conjecture holds for countable matroids having only finitary and cofinitary components.
An examination of auxetic componentry for applications in human-centred biomedical product design settings
Authors: Urquhart Lewis , Tamburrino Francesco , Neri Paolo , Wodehouse Andrew , Fingland Craig , Razionale Armando Viviano
Published: December 2023

This paper explores how the examination of additively manufactured auxetic componentry can be applied in human-centred design settings with particular focus on biomedical products. Firstly, the design applications of auxetics are detailed followed by a review of the key problems facing practical researchers in the field with the treatment of boundary conditions identified as a key issue. The testing setup that is then introduced utilises a novel method of part mounting and facilitates optical analysis and real-time force–displacement measurements. A study is advanced that analyses three different auxetic structures (re-entrant, chiral, and semi-rigid), a set of samples of which were additively manufactured in flexible TPU material. A range of parameters were varied across the three designs including interior geometry and wall thicknesses in order to demonstrate the effectiveness of the setup for the examination of the different structures. The results from these examinations are subsequently discussed and a number of suggestions made regarding how this kind of analysis may be integrated into novel design development workflows for achieving human-centred biomedical devices which often require detailed consideration of ergonomic and usability factors.
Volatile Organic Compounds Detected in Amniotic Fluid of Women During Normal Pregnancy
Authors: Minet-Quinard Régine , Goncalves-Mendes Nicolas , Gallot Denis , Pereira Bruno , Lambert Celine , Brailova Marina , Blanchon Loic , Bouvier Damien , Sapin Vincent
Published: December 2023

Exposure to volatile organic compounds (VOCs) during the fetal period may induce negative effects on children’s health (e.g. increased risk of low birth weight and imbalanced development). Whereas VOCs have been analysed extensively in various human biological fluids (i.e. urine, blood, and breath), during pregnancy only urine has been studied and no work has been performed on amniotic fluid (AF), which is in direct contact with the fetus and is essential for its well-balanced development and maturation. This study aimed to detect VOCs in AF and to investigate their links to the lifestyle habits of pregnant women. The VOC composition of the AF collected from 76 healthy pregnant women was analysed using a gas chromatograph coupled to a mass spectrometer. The sources of VOC exposure in pregnant women were assessed using a questionnaire about their home living conditions and their professional exposure. A total of 126 VOCs belonging to 13 chemical families were detected in AF. The majority of these VOCs (92) had an exogenous origin, and their presence was linked to lifestyle habits, especially smoking and fragrance use. Considering the direct contact of these VOCs with multiple fetal organs, this study is an important contribution to the literature exploring the future potential relationships between VOCs and abnormal fetal development.
Enhancing Phosphorus Fertilizer Value of Sewage Sludge Ashes and Biochars Through Chemical Pre-treatments and Application Methods
Authors: Kopp Clara , Sica Pietro , Eising Annika Grubbe , Madsen Ditte Egeberg , Magid Jakob , Müller-Stöver Dorette S.
Published: December 2023

Purpose

This study aimed to improve the phosphorus (P) fertilizer value of sewage sludge ashes and biochars through different pre-treatments and application methods.

Methods

In experiment 1, two sewage sludges, their respective ash, and biochar underwent three chemical pre-treatments (H2SO4, NaOH, and Ca(OH)2. These materials were utilized as P fertilizers in a maize plant trial), using two application methods (mixed and placed). In experiment 2, biochars sourced from four sewage sludges were pre-treated with H2SO4 and NaOH and then employed as P fertilizers in a barley plant trial.

Results

Experiment 1 revealed a significant impact of application method on shoot dry matter, with mixing outperforming placement. Acidification pre-treatment of the ash led to significantly higher shoot dry matter (2.7 ± 0.3 g) and P uptake (7.9 ± 0.9 mg per plant) compared to untreated ash (0.7 ± 0.1 g; 1.9 ± 0.2 mg per plant). Similarly, NaOH-treated biochar caused elevated shoot dry matter (2.6 ± 0.4 g) and P uptake (6.9 ± 0.4 mg per plant) compared to untreated biochar (0.7 ± 0.2 g; 1.9 ± 0.1 mg per plant). These outcomes highlight the dependence of pre-treatment efficacy on biomaterial composition. Experiment 2 demonstrated that despite differing elemental compositions of the biochars, NaOH treatment led to significantly greater shoot dry matter and P uptake compared to untreated and acidified treatments.

Conclusions

Chemical pre-treatments have the potential to enhance the short-term P fertilizer value of ashes and biochar. However, further studies are essential to assess the economic feasibility and potential environmental risks, including increased heavy metal solubility.

Graphical Abstract
A comprehensive analysis of transient rate and rate derivative data of an oil well intercepted by infinite-conductivity hydraulic fracture in closed systems
Authors: Malallah Adel , Nashawi Ibrahim Sami , Algharaib Meshal
Published: December 2023

This paper presents a method for analyzing constant-pressure drawdown test of infinite-conductivity fractured wells in bounded reservoirs. The presented method is based on the Tiab direct synthesis approach. The fracture and reservoir parameters are directly determined from the rate and rate derivative of the well test data. New equations describing the elliptical flow regime and the transition from the pseudoradial regime to the boundary-dominated regime of different rectangular reservoirs are also presented. The various flow regimes occurring during the well test are easily identified based on the shape of the plotted data and the slope of each flow regime. The unique features of the slopes of the various regimes and their intersection points are utilized to determine the fracture half-length, formation permeability, skin factor, well drainage area, and reservoir shape factor. Moreover, new equations defining the intersection points of the straight lines corresponding to different flow regimes are presented. These equations are very important for confirming the precision of the calculated results. A systematic process demonstrating the application of the proposed method to linear, elliptical, pseudoradial, and boundary-dominated regimes is well delineated. Comprehensive examples are presented to validate the efficiency of the proposed technique. The examples show that even if some of the flow regimes are not fully developed, the method can still be used to determine the formation and fracture properties using information obtained from the remaining flow regimes. This is one of several advantages of the proposed technique over conventional techniques.
ExaPRR: A Framework for Support Dynamic and Interactive Events on Distributed Published Resource Repositories Mechanism in Distributed Exascale Computing Systems
Authors: Khoshrooynemati Tayebeh , Khaneghah Ehsan Mousavi
Published: December 2023

This paper introduces the ExaPRR Framework, which is capable of managing and controlling dynamic and interactive events in addition to activities related to distributed Published Resources Repository, managing and controlling dynamic and interactive events of the said resource discovery (RD) by redefining the concept of request and response based on wave model. For this purpose, while analyzing the function of the Distributed Published Resource Repository RD and defining the concept of the next element participating in the global activity in this RD, it redefines the concept of request in the Distributed Exascale systems. This framework uses the concept of revising the state of implementation of dynamic and interactive events in the system and redefining the concept of request at every moment of the process of implementation of resource discovery activities based on system status, demanding requests, and dynamic and interactive event, manages the resource's discovery activities.
The Pastoral Epistles
Authors: McKnight Scot
Published: December 2023

In the church tradition three letters, now known as the Pastoral Epistles, are attributed to the apostle Paul. They are unlike any other letters by Paul. They are written to two of his closest companions, Timothy and Titus, and they instruct those two leaders how to lead gathered Christians in Ephesus and in Crete. The letters contain plenty of instruction for how church leaders at that time, and in those places, were to function. In this commentary, Scot McKnight seeks to explain the major themes of the Pastoral Epistles - church order, false teaching, and failing Christians - and their foundational vision for how Christians could make a good impression in public life. These three brief letters express a view of how Christians were to live in the Roman empire in a way that does not offend public sensibilities. They prescribe a way of public behavior best translated as 'civilized religion.'
A cluster of three extrapulmonary Mycobacterium abscessus infections linked to well-maintained water-based heater-cooler devices
Authors: Seidelman Jessica L. , Baker Arthur W. , Lewis Sarah S. , Warren Bobby G. , Barrett Aaron , Graves Amanda , King Carly , Taylor Bonnie , Engel Jill , Bonnadonna Desiree , Milano Carmelo , Wallace Richard J. , Stiegel Matthew , Anderson Deverick J. , Smith Becky A.
Published: December 2023

Background:

Various water-based heater-cooler devices (HCDs) have been implicated in nontuberculous mycobacteria outbreaks. Ongoing rigorous surveillance for healthcare-associated M. abscessus (HA-Mab) put in place following a prior institutional outbreak of M. abscessus alerted investigators to a cluster of 3 extrapulmonary M. abscessus infections among patients who had undergone cardiothoracic surgery.

Methods:

Investigators convened a multidisciplinary team and launched a comprehensive investigation to identify potential sources of M. abscessus in the healthcare setting. Adherence to tap water avoidance protocols during patient care and HCD cleaning, disinfection, and maintenance practices were reviewed. Relevant environmental samples were obtained. Patient and environmental M. abscessus isolates were compared using multilocus-sequence typing and pulsed-field gel electrophoresis. Smoke testing was performed to evaluate the potential for aerosol generation and dispersion during HCD use. The entire HCD fleet was replaced to mitigate continued transmission.

Results:

Clinical presentations of case patients and epidemiologic data supported intraoperative acquisition. M. abscessus was isolated from HCDs used on patients and molecular comparison with patient isolates demonstrated clonality. Smoke testing simulated aerosolization of M. abscessus from HCDs during device operation. Because the HCD fleet was replaced, no additional extrapulmonary HA-Mab infections due to the unique clone identified in this cluster have been detected.

Conclusions:

Despite adhering to HCD cleaning and disinfection strategies beyond manufacturer instructions for use, HCDs became colonized with and ultimately transmitted M. abscessus to 3 patients. Design modifications to better contain aerosols or filter exhaust during device operation are needed to prevent NTM transmission events from water-based HCDs.
Intake levels and main sources of nutrients for Japanese children with motor or intellectual disabilities
Authors: Takezoe Toshiko , Murakami Kentaro , Fujishiro Jun , Horikawa Miwako , Kubota Mitsuru , Kanamori Yutaka , Takahashi Nagahisa , Nakano Yuko , Migita Misato , Matsufuji Hiroshi , Sasaki Satoshi
Published: December 2023

Proper nutritional management is important for the growth and development of children with motor or intellectual disabilities; however, few studies have investigated the nutrient intake of children with disabilities. This study aimed to investigate the nutrient intake and food groups that are the main sources of nutrients for children with disabilities. This cross-sectional observational study included twenty-five children (mean age, 11⋅8 years) from five hospitals in Japan. Using a 3-d weighed dietary record, we estimated the daily nutrient intake and food and beverage sources that contributed to nutrient intake. The mean values of calcium, magnesium, iron, vitamin A, thiamine, riboflavin, and vitamin C intake were below the recommended dietary allowance, and those of dietary fiber and potassium were below the levels recommended by the Tentative Dietary Goal for Preventing Lifestyle-related Diseases (DG). In contrast, the mean intake values of fat, saturated fatty acids, and sodium were above the DG levels. Dairy products, meat, vegetables, and cereals were found to be the major contributors of nutrients. Increased intake of vegetables may help alleviate insufficient micronutrient intake in children with disabilities.
Can a wine be feminine? Gendered wine descriptors and quality, price, and aging potential
Authors: Masset Philippe , Terrier Lohyd , Livat Florine
Published: December 2023

By analyzing more than 1,400 expert tasting notes, we assess the so-called gender profile of Bordeaux wines. We identify 329 gender-related wine descriptors, with a good balance between masculine and feminine descriptors. Some wines and vintages are described as more feminine than others, but no clear trend over time emerges. Our regression analysis further reveals that more feminine wines receive similar ratings and sell at similar prices as their more masculine counterparts, but they are perceived as having a much more limited aging potential.
Performing Celebrity and Anna Renzi's Cross-Dressed Performance as Ergindo
Authors: Wier Claudia Rene
Published: December 2023

Quickly Ascending to Heaven,Hermaphrodite Beautyof the celestial magic,You descend to animateAngelic aura,alone in your clear, eternal beautyall other beauties stand before you.While ANNA's voice,In Deidamia converses,a musical passage dissolvesin the aura, a most divine rayalthough enclosed within an earthly veil,it knows the harmony of heaven on earth.1
Repeated freezing impacts buoyancy and photosynthesis of a rafting kelp species
Authors: Sinclair Sophie M. , Duffy Grant A. , Fraser Ceridwen I.
Published: December 2023

Antarctica was once considered biologically isolated, surrounded by oceanic barriers (Fraser et al.2018). However, floating materials such as kelp rafts (Fraser et al.2018, Avila et al.2020), wood (Lewis et al.2005) and plastics (Avila et al.2020) are now known to cross these barriers and reach Antarctic shores. Such incursions might enable non-native species (either rafting species themselves or associated hitchhikers) to colonize Antarctica as the climate warms (Avila et al.2020, Fraser et al.2020), but whether these species will be able to survive and reproduce in the Antarctic is not yet known. Sea ice is a defining characteristic of Antarctic coastlines, and modelled trajectories of kelp rafts (Fraser et al.2018) cross-referenced against sea-ice observations (Parkinson 2019) suggest that collisions between rafts and seasonal sea ice occur frequently (Fig. 1a); thus, rafts are expected to be entrained in, on or under sea ice and experience multiple freeze-and-thaw cycles on their journeys to Antarctica. In addition, kelp rafts that reach the Antarctic intertidal will experience temperatures well below 0°C if exposed to the air at low tide. Freezing can cause severe disruptive stress to seaweeds, and ice crystals growing in intercellular spaces can damage cell membranes and cause cell lysis (Eggert 2012). Such damage could affect the buoyancy of kelp tissue and decrease rafting ability. Although some non-native kelp rafts recovered from Antarctic shores appeared to still be reproductively viable, with mature gametes observed in reproductive tissue (Fraser et al.2018), tissue damage caused by freezing could have widespread effects on the health, function and establishment success of a non-native species traversing the Southern Ocean.
Pain management in infant immunisation: A cross-sectional survey of UK primary care nurses
Authors: Mabbott Annie P. , Bedford Helen
Published: December 2023

Background:

Childhood immunisation is a critically important public health initiative. However, since most vaccines are administered by injection, it is associated with considerable pain and distress. Despite evidence demonstrating the efficacy of various pain management strategies, the frequency with which these are used during routine infant vaccinations in UK practice is unknown.

Aim:

This study aimed to explore primary care practice nurses’ (PNs) use of evidence-based pain management strategies during infant immunisation, as well as barriers to evidence-based practice.

Methods:

A questionnaire was developed and distributed to nurses throughout the UK via convenience sampling in paper and online formats. Questions assessed the frequency of pain management intervention use during infant immunisation and barriers to their use.

Findings:

A total of 255 questionnaire responses were received. Over 90% (n = 226) of respondents never used topical anaesthetics or sweet solutions during immunisations, while 41.9% advised breastfeeding occasionally (n = 103). Parent-/caregiver-led distraction was the most frequently used intervention, with most nurses using it occasionally (47.9%, n = 116) or often (30.6%, n = 74). Most practices had no immunisation pain management policy (81.1%, n = 184), and most PNs’ previous training had not included pain management (86.9%, n = 186). Barriers to intervention use included lack of time, knowledge and resources. Excluding distraction, pain management strategies were infrequently or never used during infant immunisation. Key barriers to using evidence-based strategies were lack of time, knowledge and resources.
THE CERESA CLASS: TROPICAL, TOPOLOGICAL AND ALGEBRAIC
Authors: Corey Daniel , Ellenberg Jordan , Li Wanlin
Published: December 2023

The Ceresa cycle is an algebraic cycle attached to a smooth algebraic curve with a marked point, which is trivial when the curve is hyperelliptic with a marked Weierstrass point. The image of the Ceresa cycle under a certain cycle class map provides a class in étale cohomology called the Ceresa class. Describing the Ceresa class explicitly for nonhyperelliptic curves is in general not easy. We present a ‘combinatorialization’ of this problem, explaining how to define a Ceresa class for a tropical algebraic curve and also for a topological surface endowed with a multiset of commuting Dehn twists (where it is related to the Morita cocycle on the mapping class group). We explain how these are related to the Ceresa class of a smooth algebraic curve over
$\mathbb {C}(\!(t)\!)$
and show that the Ceresa class in each of these settings is torsion.
Genetic diversity and stability analysis of sweet potato accessions of north-eastern India grown under the mid-hill conditions of Meghalaya
Authors: Verma Veerendra Kumar , Kumar Amit , Rymbai Heiplanmi , Talang Hammylliende , Devi M. Bilashini , Baiswar Pankaj , Hazarika S.
Published: December 2023

A total of 32 sweet potato genotypes were evaluated to assess the genetic diversity based on quantitative traits and molecular markers, as well as stability for yield and related traits. Wider variability was observed for the traits like vine length (181.2–501.3 cm), number of leaves/plant (103.0–414.0 cm), internodal length (3.20–14.80 cm), petiole length (6.5–21.3 cm), leaf length (8.50–14.5 cm), leaf breadth (8.20–15.30 cm), leaf area (42.50–115.62 cm2), tuber length (7.77–18.07 cm), tuber diameter (2.67–6.90 cm), tuber weight (65.60–192.09 g), tuber yield (7.77–28.87 t ha−1), dry matter (27.34–36.41%), total sugar (4.50–5.70%) and starch (18.50–29.92%) content. Desirable traits such as tuber yield, dry matter and starch content have shown high heritability (>60%) with moderate to high genetic advance. Under molecular analysis, a total of 232 alleles were observed from all 32 microsatellite markers, which ranged from 4 to 14 with an average of 7.77 alleles per locus. In the population, the average observed heterozygosity (0.51) was higher than the expected heterozygosity (0.49). The contribution of genotype, genotype by environment interaction to the total variations was found to be significant. Based on the multi-trait stability index (tuber length, tuber diameter, tuber weight and tuber yield), genotypes X-24, MLSPC-3, MLSPC-5, ARSPC-1 and TSP-12-12 were found to be most stable. Among them, the high-yielding and stable genotypes TSP-12-10 (26.0 t ha−1) and MLSPC-3 (23.9 t ha−1) can be promoted for commercial production or used as parental material in future crop improvement programmes.
Feral rye (Secale cereale L.) control in quizalofop-resistant winter wheat in Oregon
Authors: Ribeiro Victor H. V. , Mallory-Smith Carol A. , Gourlie Jennifer A. , Shelton Chad W. , Barroso Judit
Published: December 2023

Managing winter annual grass weeds has long been a challenge in the dryland regions of the Pacific Northwest (PNW) where soft white winter wheat is grown. The recent development of quizalofop-resistant (CoAXium) wheat varieties allows growers to use quizalofop (QP), a herbicide that inhibits acetyl-CoA carboxylase (ACCase) for postemergence grass control. Field experiments were conducted over two winter wheat growing seasons in 2021–2022 and 2022–2023 near Adams, OR, to evaluate QP efficacy on feral rye and for crop safety. Downy brome and jointed goatgrass control with QP were assessed in 2021–2022 and 2022–2023, respectively. QP treatments provided effective control of feral rye (≥95%), downy brome (≥87%), and jointed goatgrass (99%) regardless of rate, adjuvant, and spray volume tested. Spring-applied QP caused no injury to winter wheat. Results indicate that the QP-resistant wheat technology can help PNW wheat growers selectively control winter annual grasses.
In-patient characteristics of peripheral artery disease in	Germany
Authors: Block Alexander , Köppe Jeanette , Feld Jannik , Kühnemund Leonie , Engelbertz Christiane , Makowski Lena , Malyar Nasser , Gerß Joachim , Reinecke Holger , Freisinger Eva
Published: December 2023

Summary: Background: Peripheral artery disease (PAD) frequently leads to hospital admission. Sex related differences in in-patient care are a current matter of debate. Patients and methods: Data were provided from the German national in-patient sample provided by the Federal Bureau of Statistics (DESTATIS). Trends on risk profiles, therapeutic procedures, and outcomes were evaluated from 2014 until 2019 stratified by sex and PAD severity. Results: Two-thirds of an annual >191,000 PAD in-patient cases applied to male sex. Chronic limb-threatening ischemia (CLTI) was recorded in 49.6% of male and 55.2% of female cases (2019). CLTI was as a major risk factor of in-hospital amputation (OR 229) and death (OR 10.5), whereas endovascular revascularisation (EVR) with drug-coated devices were associated with decreased risk of in-hospital amputation (OR 0.52; all p<0.001). EVR applied in 47% of CLTI cases compared to 71% in intermittent claudication (IC) irrespective of sex. In-hospital mortality was 4.3% in male vs. 4.8% in female CLTI cases, minor amputations 18.4% vs. 10.9%, and major amputation 7.5% vs. 6.0%, respectively (data 2019; all p<0.001). After adjustment, female sex was associated with lower risk of amputation (OR 0.63) and death (OR 0.96) during in-patient stay. Conclusions: Male PAD patients were twice as likely to be admitted for in-patient treatment despite equal PAD prevalence in the general population. Among in-patient cases, supply with invasive therapy did not relevantly differ by sex, however is strongly reduced in CLTI. CLTI is a major risk factor of adverse short-term outcomes, whereas female sex was associated with lower risk of in-patient amputation and/or death.