bluuebunny/crossref_metadata_2025 huggingface dataset:
Artificial Intelligence in Automated Testing Environments
Authors: Mothey Mouna
Published: December 2024

Artificial intelligence is developing at a breakneck pace, and its combination with automation has begun to transform the corporate environment. Businesses are concentrating on employing current AI in conjunction with automated procedures to achieve unprecedented levels of productivity and quality. The revolutionary impact of AI-driven reporting for test automation is explored in this research study. By using artificial intelligence, we enable test automation to provide useful insights in addition to problem detection. Every day, enormous volumes of data are produced from several sources, which must be properly tracked, analysed, reported on, and used to guide action. With the development of more sophisticated software programs, time is becoming a crucial consideration in the deployment of applications that need to be thoroughly tested and adhere to business requirements. AI is essential to software testing because it can provide faster and more reliable findings. These malfunctions may be hazardous and often happen during testing. Understanding component behaviour is essential for putting into practice effective defences against failure. While it is currently difficult to predict random component failures, artificial intelligence (AI) enables predictive failure simulation by intelligently simulating real-world conditions. Failure prediction is then possible by comparing simulated component behaviour with actual data, which is useful for maintenance and spare provisioning plans. As AI technology in automotive systems continues to advance, it is becoming increasingly important to address current issues and prevent future failures. Virtual reality and preventive maintenance are essential for understanding system behaviour and preventing failures.
Automated Chargeback Management: Increasing Win Rates with Machine Learning
Authors: Jeyachandran Pradeep , Abdul Rafa , Satya Sanyasi Sarat , Singh Niharika , Goel Om , Chhapola Kshun
Published: December 2024

Automated chargeback management is an emerging solution that leverages machine learning (ML) to enhance the efficiency and effectiveness of chargeback dispute processes in the financial and e-commerce sectors. Chargebacks, which occur when a consumer disputes a transaction, can result in significant losses and operational inefficiencies for merchants. Traditional chargeback management involves manual review of disputes, which is often time-consuming and prone to errors. By integrating machine learning techniques, organizations can significantly improve their win rates in chargeback disputes, reduce manual effort, and streamline decision-making processes.
Machine learning models are capable of analyzing large volumes of transactional data to identify patterns and predict the likelihood of chargeback success or failure. These models can classify chargebacks by their likelihood of being overturned, enabling merchants to focus on high-risk cases and prioritize efforts on those most likely to succeed. Additionally, machine learning algorithms can help identify fraudulent chargebacks, reduce false claims, and automate responses, further enhancing operational efficiency.
By automating routine tasks, chargeback management solutions powered by machine learning not only improve win rates but also reduce operational costs and enhance customer experience. Furthermore, such systems provide valuable insights into consumer behavior, enabling merchants to better understand and address underlying issues that contribute to chargebacks. As e-commerce and online payments continue to grow, automated chargeback management will play a crucial role in mitigating risks and ensuring sustainable financial operations for merchants.
A Critical Analysis of the Impact of Virtual Laboratories on Educational Advancement
Authors: Ahzan Zulkaidah Nur , Kusumah Yaya Sukjaya , Herman Tatang
Published: December 2024

This article presents the findings of a comprehensive literature review that investigates the use of virtual laboratories in educational settings. Virtual laboratories offer numerous advantages for students, teachers, and the advancement of a nation, particularly in the realm of education and learning. Some advantages of this platform include the promotion of students' critical thinking abilities, cost-effectiveness due to its modest resource requirements, adaptability, flexibility, and enhancement of students' scientific literacy. Nevertheless, despite the advantages offered by virtual laboratories, it is crucial to continuously evaluate this platform. For example, the proficiency of instructors who teach students via virtual laboratories, as well as the instructional materials used in this platform, need to be constantly updated. A systematic literature analysis was conducted on 10 publications retrieved from multiple databases. The findings of the review indicate that virtual laboratories in education have a positive impact across various domains such as enhancing students' cognitive capacities, enhancing the efficiency of e-learning, being cost-effective and adaptable, and enhancing students' scientific literacy skills.
The Influence of Cyberloafing Behavior and Job Stress on Employee Performance
Authors: Juwita Juwita , Ahman Eeng , Sojanah Janah , Rofaida Rofi
Published: December 2024

The purpose of this study was to determine the effect of cyberloafing behavior and job stress on employee performance in S2 Store Kendari. The object of this research is the effect of cyberloafing behavior and job stress on employee performance in S2 Store Kendari. The sample in this study were 30 respondents. This type of research is quantitative research where the data collection uses a questionnaire as a research instrument. The data collection method used in this study is to use the method of distributing questionnaires to 30 respondents. After the data was collected, the data was then analyzed using multiple linear regression analysis with the help of SPSS for windows 20. Based on the results of data analysis that has been carried out, it can be concluded that there is an influence of cyberloafing behavior and job stress on the performance of S2 Store Kendari employees, meaning that high cyberloafing behavior and job stress felt by employees can have a significant influence on the performance of S2 Store Kendari employees either simultaneously or partially.
Translation, Cultural Adaptation, and Validation of the Urdu Version of Irritable Bowel Syndrome Severity Scoring System
Authors: Niazi Yasmeen , Ejaz Bisma
Published: December 2024

The Irritable Bowel Syndrome Severity Scoring System (IBS-SSS) is a widely utilized tool for screening and classifying IBS patients according to the severity of their symptoms. This study aimed to translate the IBS-SSS into Urdu, culturally adapt it, and validate it for the Urdu-speaking Pakistani population.  The translation process involved forward translation, reconciliation, backward translation, an expert committee review, and cognitive interviewing to ensure conceptual and semantic precision. The final Urdu-translated scale was administered to 250 participants (146 females and 104 males) aged 18-67 years (M = 35.69, SD = 12.56). Structural validity was assessed using EFA. The IBS-SSS scores were correlated with GSRS-IBS to determine the convergent validity, while the scores of IBS patients were compared with healthy individuals on different severity levels to explore the discriminant validity. The EFA confirmed the scale's unidimensionality with the KMO measure of the adequacy of 0.91 and Bartlet test of sphericity being significant (p > .001). The reliability assessment suggested robust results with Cronbach’s alpha a = 0.96, indicating high inter-item internal consistency, test-retest reliability ranging from 0.89 to 0.98, and the split-half reliability score yielding highly significant results with a = 0.92 (p < 0.01). Convergent validity revealed a moderate to strong correlation with a value of  (r = .65, p < 0.01). For discriminant validity, significant differences in the scores of IBS patients and non-patients were observed, where IBS patients scored higher on all IBS types irrespective of their symptom severity (p < .001). The findings indicated that the Urdu-translated version of IBS-SSS is a reliable and valid tool for the assessment of symptom severity in the Pakistani population with IBS. Future studies should investigate the applicability of the scale across diverse Urdu-speaking populations and IBS subtypes, examining its validity in longitudinal studies.
Pharmacogenomics of Low Dose Empagliflozin and its Association with Treatment Outcomes inPatients with Heart failure
Authors: Ain Qurat ul
Published: December 2024

Heart failure (HF) is a complex clinical syndrome resulting from structural or functional cardiac disorders that impair the ventricle's ability to fill or eject blood, affecting 1-2% of the global population. Apoptosis, myocyte death, and disruptions in calcium homeostasis are all part of the pathophysiology of HF, with ATP2A2 (SERCA2a) failure being a major contributing factor. Furthermore, neurotrophins, such as Brain-DerivedNeurotrophic Factor (BDNF), have been linked to the development of cardiovascular disorders, underscoring their potential as therapeutic targets and biomarkers. The purpose of this study is to examine the clinical effectiveness of low-dose empagliflozin in patients with heart failure, with particular emphasis on the part played by genetic variations in the ATP2A2 (rs1860561) and BDNF (rs6265) genes. 112 Patients ranged in age from 18 to 75 years having a confirmed diagnosis of heart failure, a stabletreatment regimen for at least three months, and a left ventricular ejection fraction (LVEF) between 25% and 45% or preserved (≥45%) were included in the study. Exclusion criteria were pregnancy, recent hospitalization, severe renal impairment, and major comorbidities that affected BNP levels. The patients with heart failure who were enrolled provided DNA samples for genetic analysis. BNP and EF changes were measured before and after patients received low-dose empagliflozin therapy. Sanger sequencing was used to genotype the BDNF gene for rs6265 and the ATP2A2 gene for rs1860561. Analysis was done on genotype distributions and how they relate to therapy response. The mean BNP levels in all patients dropped from 1073.75 pg/mL prior to therapy to 608.78 pg/mL following treatment (p = 0.0094). The group as a whole showed no discernible change in EF (mean rise from 36.7 to 38.25, p = 0.2623). In responder groups, EF increased from 35.16 to 39.75 (p = 0.00187), while BNP levels dramatically dropped from 1161.88 pg/mL to 511.97 pg/mL (p = 0.0056). A positive response to therapy was linked to the BDNF rs6265 polymorphism, with the CC genotype exhibiting the greatest gains in BNP reduction and enhancement in EF. The BNP decrease response rate was 90.91% for patients with the CC genotype and lower for those with the T allele (p = 0.612). 76.92% of respondents with the CC genotype had EF, while the CT genotype had a significantly lower response rate (16.67%, p =0.013). For ATP2A2 rs1860561, the GA genotype was linked to a higher proportion of x responders (88.89%) compared to the GG genotype (71.43%), indicating a more favorable response in GA carriers.
Characterization of RNASE L, Ankyrin Repeat Domain mutation Gene of RNASE L Gene in Gastric Cancer patients in Pakistani Population
Authors: Liaquat ali Anum , Ansari maqsood ansari , Haider Ghulam haider , Hanif Farina hanif , Zahid SIKANDAR ali , Imran Hoor fatima
Published: December 2024

Gastric carcinoma is the fourth most common type of cancer and the second leading cause of cancer death in the world. And mortality rate are still high with more than 1 000 000 cases in2018. . According to Worldwide data 2018, Around one in 12 of all oncological deaths are caused by gastric cancer.It has the5th ( fifth) highest occurrence amongst cancers, 5.7% of all young people infected with the disease. Gastric cancer is too individual of the behaviorally influenced, and therefore preventable of the cancers Gastric cancer has highest risks which have been reported in the central Africa, Eastern Asia and Western Africa. Gastric cancer patients 80% to 90% that has been observed which initiation of the cancer is due to the H pylori. Many types of the gene mutations are too involved in Gastric cancer pathogenesis. RNASE L is the important significant roles in the antiviral response. That is controlled by interferon and the involved in cleavage of viral RNA for that reason the aim of this research study is to identify RNASE and ANK domain mutation/s of RNAS E L gene in gastric cancer patients. Methodology Total 120 blood samples was collected in this study. DNA extracted through the PCR. To analyze .the RANSE-L amplified PCR product the gel-electrophoresis performed. After that The amplified samples of RANSE-L was sent to the directed Macrogen, Korea for the sequencing although analysis of mutation done through Bio Edit and MEGA11 software.. All mutations of RNASE-L gene associated with H pylori . Result The types of our research sample were; 1: GC patients positive, 2: Patients of GC with H-pylori positive and 3: diagnosed patients of H-pylori . Out of 120 samples of blood, 5%, of GC, 50% are of GC alongside with H pylori, and the residual samples of blood are of H-pylori positive individuals. Of these, 58.3% are men and 41.6% are women. Sequence examination revealed that one (1) only sample had SNV(single nucleotides variant) G>A in the domain of RNASE, and not of any one sample had SNV in domain ARD . Conclusion In this research study, we tried to analyze genetically feature of GC therefore which it can support us therapeutically. Our healthcare organization is in very necessity of certain immediate improvements which are essential to control peoples of GC
The Role of Gut Microbiota in Thalassemia Treatment using Hydroxyurea: Friend or Foe?
Authors: Khan Ayesha , Khan Saeed , Ansari Saqib Hussain , Ahmed Ayaz , Khan Asif Iqbal , Omair Muniza
Published: December 2024

Hydroxyurea (HU), a fetal hemoglobin inducer, effectively alleviates symptoms in beta-thalassemia patients; however, its efficacy varies among individuals, potentially due to differences in hydroxyurea metabolism and composition of the gut microbiota. Previous studies have indicated that these factors can influence drug and disease metabolism, including that of thalassemia. This study aimed to establish a link between the gut microbiota and hydroxyurea response in beta-thalassemia major patients. Stool samples were collected from 45 beta-thalassemia patients and classified into three groups: responders, non-responders, and those not using hydroxyurea. Sequencing was performed on the V3-V4 hyper-variable region of the 16SrRNA gene. The analysis uncovered noteworthy distinctions in the gut microbiota among the three groups at both the genus and species levels. The response to hydroxyurea was associated with butyrate-producing bacteria from the phylum Firmicutes. Responders exhibited an enrichment in butyrate-producing bacteria such as Faecalibacterium, Butyrivibrio, Oscillobacter, Gemmiger, and Eubacterium. Non-responders, on the other hand, had higher levels of Prevotella, Mitsuokella, and Treponema. Non-users were characterized by an abundance of Succinivibrio, followed by Bacteroides and Megasphaera. These findings suggest that altered gut microbiota may contribute to inter-individual variation in hydroxyurea response, highlighting specific microbes that could potentially serve as biomarkers for thalassemia or predict hydroxyurea efficacy.
Mushroom production, research and market in Pakistan
Authors: Mehmood Basharat
Published: December 2024

Mushroom is extensively produced for human consumption in many nations, including Pakistan due to their high protein and vitamin content. Pakistan boasts a high diversity of mushrooms because of its harsh geographical conditions and seasonal variations. Due to the plentiful supply of agro-wastes that make mushroom production possible, mushroom manufacturing is one of Pakistan’s most potential cottage industries. The most popular commercially produced mushroom species are Oyster, Straw, and Button mushrooms; however, the most common and best-selling variety is the white button mushroom (Agaricus bisporus). This review article’s objective is to gather information regarding Pakistan’s mushroom production. Despite an increase in mushroom production, there are some issues that mushroom producers face during production and marketing that need to be resolved for further development of this sector. In light of the nation’s land scarcity and high unemployment rate, boosting mushroom production may be a viable strategy for boosting the rural economy. The growth of this industry would also enhance the variety of company ventures and job prospects in semi-urban and rural regions.
Precision Medicine & Drug Repurposing for Cardiovascular Diseases; Challenges and Opportunities
Authors: Ahmed Sagheer
Published: December 2024

The use of a therapeutic agent other than its intended purpose is referred to as drug repurposing. The principle is of particular benefit as it allows for shorter timelines and lower developmental costs as compared to the development of a novel drug. Systematic drug repurposing has now opened new avenues. However, clinical successes for cardiovascular are hard to seek. Henceforth, systematic drug repurposing despite having a lot of potential, is not without significant barriers that have to be overcome. Some of the barriers are associated with the potential favorable benefit to risk ratio, however, adverse effects are not a major concern when it comes to drugs being repurposed. More nuanced barriers such as issues with intellectual property that can decrease financial incentives are also significant.
Induced pluripotent stem cell technology is the front runner for addressing monogenic pathologies. However, due to the rare occurrence of these monogenic diseases, lower financial gains also serve as a discouraging factor. Strategies such as second medical use patents have been introduced to enhance drug repurposing, but skepticism with regards to establishing non-obviousness and evading competition from already approved generics in the market is a hurdle. As a result, it is incumbent that reforms be made to bolster drug re-engineering, repurposing be introduced and specific recommendations proposed to actualize the benefits of drug repurposing to the fullest
For systematic repurposing specific to the diseases of the cardiovascular systems, innovation in two domains of personalized medicine: 1) Predictive models to screen for the disease-modifying activity of active compounds and 2) Computational approaches to associate drug effects with disease signatures should be made simultaneously to streamline the process of cardiovascular drug repurposing. In truth, the combination of experimental and computational approaches has dawned a new age in drug repurposing. The high-throughput drug screening is achieved experimentally whereas the computational side deals with the manipulation of large datasets of both the drug effects as well as the molecular and phenotypical characteristics of the disease. This allows for gauging the mechanism of action of the drug with the disease pathology, aiding if required, drug repurposing based on the disease-modifying effects. With sufficient intellectual and financial backing, experimental and computational technologies could be optimized to enhance drug discovery and repurposing for cardiovascular diseases.
Carbamazepine Resistance in Epileptic Patients & Its Association with Genetic Polymorphism
Authors: Mubarak Juhainah , Bangash Hamza Hussain , Manzoor Zahra Batool , Zaman Zainab
Published: December 2024

Epilepsy is a brain disorder with a lasting tendency to produce epileptic episodes. It carries neurological, cognitive, psychological, and social consequences. Carbamazepine (CBZ) is one of the most widely prescribed antiepileptic drugs. It is first-line therapy to treat partial tonic-clonic seizures, trigeminal, glossopharyngeal neuralgias, and bipolar disorder. The main goal of epilepsy treatment is to avoid seizures without detrimental side effects. Unfortunately, despite appropriate and adequate medication, one-third of the patients do not respond to antiepileptic drugs. Individuals with drug-resistant epilepsy have a higher risk of neurological damage, psychiatric dysfunction, lower quality of life, and even death. For a long time, genetic factors have been known to play a role in the pathophysiology of epilepsy. In parallel, pharmacogenetic factors are also hypothesized to induce drug-resistant epilepsy, with gene polymorphism being one of the most investigated. This review is a collection of studies aimed at investigating resistance to CBZ in epilepsy patients influenced by the polymorphism of genes encoding metabolic enzymes and drug transporters. Pharmacogenetic intervention is likely to improve treatment strategies and pave the way toward personalized medicine for epileptic patients.
Rapid & Low-Cost DPYD Genotyping to Guide Fluoropyrimidine Treatment in Cancer Patients
Authors: Staff Editorial
Published: December 2024

DPYD (dihydropyrimidine dehydrogenase) genotyping is relevant in the context of cancer treatment, particularly with fluoropyrimidine-based chemotherapy drugs such as 5-fluorouracil (5-FU) and capecitabine. Dihydropyrimidine dehydrogenase is an enzyme involved in the metabolism of these drugs, and certain genetic variants in the DPYD gene can lead to reduced enzyme activity, potentially causing severe and life-threatening toxicities.  The implementation of upfront DPYD genotyping involves testing patients for specific DPYD variants before starting fluoropyrimidine-based chemotherapy.  Pinheiro and colleagues assessed the frequency of the four most common and well-established DPYD variants associated with fluoropyrimidine toxicity and implemented a relatively low-cost and high-throughput genotyping assay for their detection. Their study comprised 457 patients that were genotyped for the DPYD c.1129-5923C>G, c.1679T>G, c.1905 + 1G>A and c.2846A>T variants, either by Sanger sequencing or kompetitive allele-specific PCR (KASP) technology. Of these, 172 patients presented toxicity during treatment with fluoropyrimidines (post-treatment group), and 285 were tested before treatment (pretreatment group). A little more than 7% of patients were DPYD homozygous. The most common variant they found was c.2846A>T. The KASP assays designed in this study presented 100% genotype concordance with the results obtained by Sanger sequencing. The authors concluded that the combined assessment of the four DPYD variants increases the identification of patients at high risk for developing fluoropyrimidine toxicity. They also found KASP genotyping a low-cost and rapid turnaround time assay. Pharmacogenet Genomics. 2023 Oct 1;33(8):165-171. doi: 10.1097/FPC.0000000000000505.
Genetic Determinants of Azathioprine Efficacy
Authors: Ahmed Sagheer
Published: December 2024

Azathioprine (AZA) is among the most widely prescribed immunosuppressive agents of the past five decades. It finds its application in organ transplantation therapy, autoimmune disorders, and various inflammatory conditions. However, its therapeutic efficacy is often marred by unwanted side effects or adverse drug reactions (ADRs). Polymorphism in genes like thiopurine methyltransferase (TPMT), inosine triphosphate pyrophosphatase (ITPA), nudix hydrolase 15 (NUDT15), and subsequent influences on enzymatic activity play a crucial role in modulating AZA's response and toxicity. Additionally, racial and ethnic factors further complicate the metabolic outcome of this drug. These changes can lead to undesirable outcomes like myelotoxicity, hematopoietic toxicity, neutropenia, and leukocytopenia. Due to the unpredictability of AZA outcome, elicited by genetic variations, the Food and Drug Administration (FDA) has recommended genetic screening prior to AZA therapy initiation, highlighting the move towards precision medicine. While pharmacogenetic screening is recommended, accessibility, cost, and ethical consideration remain a hurdle in its implementation. This review article will delve deep into the studies and literature available, reporting the intricate interaction between SNPs and the resulting impact on AZA efficacy. The article will also recommend how to effectively use the pharmacogenetic tools for optimizing its usage. By incorporating genetic information in treatment plans involving AZA, a patient-centered approach can be achieved, potentially optimizing efficacy, safety, and cost-effectiveness of AZA therapy.
Phytocompounds as Promising Weapons against Lung Cancer: A Review
Authors: Saleem Nida , Habib Aamna , Shafi Amber , Al-Qaneh Ayman M , Jabbar Ahmed AJ
Published: December 2024

Lung cancer is the second most prevalent form of cancer in both men and women, which incurs major economic and public health losses. Notably, easy access to tobacco is the most important cause of pulmonary cancer, with 80%–90% of cases coming from cigarette smokers. Moreover, respiratory issues caused by industrial and automobile smoke, occupational hazards like asbestos, and infections, like Covid-19, exacerbate the impact of lung cancer on the body. To mitigate these effects, traditional lung cancer treatments coupled with awareness campaigns are proving somewhat successful, but many challenges persist. Cancer-resistance development, chemotherapy-induced side effects, and cancer metastasis are some of the significant hurdles to lung chemotherapy success. Plant and phytocompounds can potentially become alternative sources of lung cancer treatments. This review article provides some insight into these natural sources. Particular, hispidulin from Saussurea involucrate, erianin from Dendrobium chrysotoxum, and albanol B from Morus alba are proven to have anti-cancer effects in lung cancer cells, proven through in vitro and in vivo animal models. Furthermore, petroleum ether and ethyl acetate extracts of Marsdenia tenacissima were found to be potent in inhibiting lung cancer cells with an IC50 value of 0.35 mg/ml. This makes M. tenacissima a suitable candidate for further exploration in lung cancer treatment. In addition to the therapeutic effects, plant-based products can also act as dietary supplements for cancer prevention, and may even be recommended for cancer patients. The possibilities are endless but require further research and resource investment for estimating the clinical efficacy, as well as robust drug-delivery mechanisms of these plants and phytocompounds for pulmonic cancer.
Scientific Evidence for the Herbal Remedies Used in the Treatment of COVID-19
Authors: Haroon Aemen , Siddiqui Hareem Arif , Aamir Eman , Bangash Hamza Hussain
Published: December 2024

The recent outbreak of coronavirus in December 2019, now officially named SARS-CoV-2 caused severe acute respiratory syndrome. The lack of significant targeted therapy options led to treating the pandemic symptomatically through the use of antivirals, anti-inflammatory agents, immunoglobulins, and low molecular weight heparins. Non-replicating viral vector vaccines have been manufactured by some organizations however the cure has still not been discovered.  Herbal remedies have been used to treat a multitude of illnesses over time and have been the foundation for uncovering the cure for some diseases. This review delves into the scientific evidence of herbs such as Curcuma longa, Glycyrrhiza glabra, and Zingiber officinale having a therapeutic effect against SARS-CoV-2 by binding to various crucial sites on the virus rendering it ineffective. Many of these phytocompounds were found to have a distinguished mechanism of action showing anti-SARS-CoV-2 activity as shown in Figures 1 and 2. Some of them have also exhibited anti-inflammatory properties. The following figure illustrates how the natural compounds mentioned in this article act on SARS-CoV-2 during its various stages of life.
El imaginario mitológico en la poética de María Eugenia Vaz Ferreira: apropiación, (re)creación y autoconciencia artística
Authors: Fernández dos Santos Mirta
Published: December 2024

La mitología de diferentes tradiciones tuvo un gran destaque durante el Modernismo hispanoamericano, por lo que la aparición del mito en la poesía modernista ya ha sido ampliamente estudiada en Darío, Lugones o Agustini, entre otros. Sin embargo, apenas ha sido objeto de indagación en relación con la obra de María Eugenia Vaz Ferreira, poeta que, además de seguir una estética modernista y simbolista, estuvo estrechamente vinculada con el imaginario romántico finisecular. Así pues, el principal objetivo de este trabajo es mostrar los resultados de la exploración de la presencia de figuras mitológicas (nórdicas, judeocristianas y grecolatinas) en su poética, a través de una revisión bibliográfica complementada con un trabajo de archivo.
Reseña: "Con los ojos abiertos. Escrituras de lo visual en las poetas sudamericanas" (2024), de María Lucía Puppo
Authors: Fabry Geneviève
Published: December 2024

Reseña: "Con los ojos abiertos. Escrituras de lo visual en las poetas sudamericanas" (2024), de María Lucía Puppo
Implementasi Peraturan Daerah Kabupaten Tangerang Nomor 2 Tahun 2010 Tentang Pnegawasan Dan Pengendalian LingkunganHidup Di Kecamatan Cikupa
Authors: ANGGIANA RUSNIA SITI , Sjafari Agus , Riswanda
Published: December 2024

Kerusakan lingkungan hidup dapat merugikan bagi pemerintah dan masyarakat seperti rusaknya sarana prasarana umum yang biasanya di gunakan oleh masyarakat seperti jalan, tempat ibadah, dan fasilitas Pendidikan. tujuan penelitian yaitu, untuk mengetahui Pelaksanaan Implementasi Peraturan Daerah Kabupaten Tangerang Nomor 2 Tahun 2010 Tentang Pengawasan dan Pengendalian Lingkungan Hidup Di Kecamatan Cikupa. Teori yang digunakan yaitu menurut pendangan Edwards III terdiri dari komunikasi, sumberdaya, disposisi, dan struktur birokrasi. Metode penelitian menggunakan penelitian kualitatif dengan pendekatan deskriptif. Teknik pengumpulan data menggunakan wawancara, observasi & studi dokumentasi. Temuan di lapangan menunjukan bahwa komunikasi antara organisasi & aktivitas pelaksana tidak optimal, dikarenakan Tarik ulur kepentingan antara pemda Kab.Tangerang dengan Pemerintah Pusat. Sumberdaya sistem pengendalian banjir di Kecamatan Cikupa tidak optimal, karena sumber daya manusia yang ada untuk pemeliharaan infrastuktur pengendali banjir masih ke kurang. Sikap/ kecenderungan para pelaksana kurang optimal karena usulan masyarakat/pihak desa yang diajukan kepada BBWS Cidanau-CiujungCidurian Sulit di realisasikan,  Struktur birokrasi dalam pelaksanaan sistem pengendali banjir di Kecamatan Cikupa tidak optimal, karena para pelaksana bekerja berdasarkan tugas pokok & fungsi masing-masing sehingga komando/perintah antar pelaksana yang terlibat tidak saling sinkron.
 
Kata Kunci: Implementasi Kebijakan, Peraturan Daerah, Lingkungan Hidup
PENGARUH USER INTERFACE DAN WORD OF MOUTH TERHADAP KEPUTUSAN PEMBELIAN DI E-COMMERCE SHOPEE
Authors: Frida Frida , Wawan Prahiawan
Published: December 2024

Bertambahnya pengguna internet memudahkan berbagi informasi, termasuk jual beli online, sehingga e-commerce memerlukan strategi untuk menarik lebih banyak pengguna. Penelitian ini bertujuan mengetahui pengaruh antarmuka pengguna dan promosi mulut ke mulut terhadap keputusan pembelian di Shopee, yang mengalami penurunan pengguna. Menggunakan pendekatan kuantitatif dan analisis deskriptif, sampel terdiri dari 105 responden dengan teknik purposive sampling. Hasil penelitian melalui berbagai uji (validitas, reliabilitas, regresi linier berganda, uji t, uji F) menunjukkan bahwa user interface dan word of Mouth berpengaruh signifikan terhadap keputusan pembelian di Shopee.
Kata Kunci: User interface, Word of Mouth, Keputusan Pembelian, E-commerce
IMPLEMENTASI UNDANG-UNDANG NOMOR 20 TAHUN 2023 BERDASARKAN GRAND DESIGN REFORMASI BIROKRASI 2010-2025
Authors: Rawinarno Tjahyo , Alynudin Suhud , Shafira Najwa , Widiarto Agus , Setyoko Haryo
Published: December 2024

Reformasi Birokrasi Indonesia sudah berjalan kurang lebih sepuluh tahun sejak  dikeluarkan grand design reformasi birokrasi. Bertujuan salah satunya adalah memastikan Aparatur Sipil Negara mampu memberikan pelayanan kepada masyarakat secara efisien. Namun, terdapat beberapa hal yang harus disesuaikan karena perkembangan zaman. Oleh karena itu, melalui penelitian ini dapat menjadi solusi terkait implementasi Undang-Undang Nomor 20 Tahun 2023. Menggunakan metode kualitatif  berdasarkan Grand Design Reformasi Birokrasi 2010-2025. Berdasarkan pendekatan tersebut, ditemukan  bahwa keberhasilan penerapan Undang-Undang tersebut dapat dilakukan apabila sesuai dengan yang sudah ditentukan.
 
Kata kunci : Reformasi Birokrasi,  Undang-Undang, Implementasi
Dutch Disease Nexus and Industrial Diversification: Evidence from Angola
Authors:   Department of Tourism, School of Hotel Management and Tourism, Agostinho Neto University, Luanda - Angola., Sanches-António Luzolo Domingos
Published: December 2024

The main objective of this study was to analyze the evolution of the main indicators of the Angolan economy between 2019 and 2023, which, in light of the literature on Dutch disease, can explain the situation of the level of industrial diversification in the period in question. Thus, a two-stage analysis was carried out: the first referred to the search for convergence between the behavior patterns of the curves of the volume of oil exports and the curve of exchange rate variation in the medium and long term; the second referred to the analysis of the trajectories of the curves of oil exports and the volume of production related to the manufacturing industry in the period between 2019-2023. Thus, the main results demonstrate, on the one hand, that both the volume of oil exports and the variation of the exchange rate had a convergent trajectory, both in the medium and long term and, on the other hand, that in the medium term (2019-2023), the volume of exports of the oil industry had an evolution dynamic inferring from that observed in the volume of the manufacturing industry. Finally, the conclusions drawn for the period analyzed support the premise that a preferential focus on exports originating from the extractive industry, combined with the observance of exchange rates that tend to appreciate, did not lead to direct deindustrialization to the detriment of the emergence of other industrial sectors besides oil, namely manufacturing.
Comparison of Tomato Fruit Juice (Lycopersicon esculentum Mill.) and Cherry Tomato Fruit Juice (Solanum lycopersicum) on Tooth Discoloration in the Teeth Bleaching Process
Authors:   Department of Dental Materials and Technology, Faculty of Dentistry, Prof. Dr. Moestopo (Beragama) University, Jakarta, Febriani Mirna , Ibrahim Irsan ,   Department of Dental Materials and Technology, Faculty of Dentistry, Prof. Dr. Moestopo (Beragama) University, Jakarta, Alawiyah Tuti ,   Department of Dental Materials and Technology, Faculty of Dentistry, Prof. Dr. Moestopo (Beragama) University, Jakarta, Oktanauli Poetry ,   Department of Oral Biology, Faculty of Dentistry, Prof. Dr. Moestopo (Beragama) University, Jakarta, Taher Pinka ,   Department of Oral Biology, Faculty of Dentistry, Prof. Dr. Moestopo (Beragama) University, Jakarta, Herawati Margaretha ,   Department of Oral Biology, Faculty of Dentistry, Prof. Dr. Moestopo (Beragama) University, Jakarta
Published: December 2024

Background: Tooth discoloration is one of the problems that makes many people feel uncomfortable when talking or smiling. Tooth discoloration can be treated with bleaching. Natural ingredients can be used as a safer and more affordable alternative to tooth bleaching. Tomato fruit (Lycopersicon esculentum Mill.) and cherry tomatoes (Solanum lycopersicum) contain hydrogen peroxide that can damage dye molecules and peroxidase enzymes that can increase the speed of hydrogen peroxide in reducing color so that it causes a whitening effect on teeth.

Objective: To determine the comparison of tomato fruit juice (Lycopersicon esculentum Mill.) and cherry tomato juice (Solanum lycopersicum) on tooth discoloration in the process of tooth bleaching.

Methods: This research is laboratory experimental research with pre-test post-test design method. The number of research samples was 27 teeth permanent incisive both upper and lower jaws soaked in tomato fruit juice (Lycopersicon esculentum Mill.) and cherry tomato juice (Solanum lycopersicum) for 1, 3, 5 hours. The study was conducted by measuring the difference in tooth color changes before and after soaking in tomato fruit juice (Lycopersicon esculentum Mill.) and cherry tomato juice (Solanum lycopersicum) using Vita Easyshade V.

Results: All sample groups produced color changes after being soaked in tomato fruit juice (Lycopersicon esculentum Mill.) and cherry tomato juice (Solanum lycopersicum). The values of paired T-test results of light, chrome, and hue showed that there were significant differences in tooth color (sig < 0.05).

Conclusion: Immersion of teeth in tomato fruit juice (Lycopersicon esculentum Mill.) and cherry tomato fruit juice (Solanum lycopersicum) can cause discoloration of teeth. The highest color change in the 5-hour immersion group in tomato fruit juice (Lycopersicon esculentum Mill.) and cherry tomato fruit juice (Solanum lycopersicum) for Lightness, Chroma and Hue values.
A New Class of Operators: LM-operators
Authors: Bayram Erdal
Published: December 2024

This paper introduces a new class of operators called LM- operators, extending the concepts of L-weakly and
M-weakly compact operators within the framework of Banach lattices. While L-weakly and M-weakly compact
operators have established properties, LM-compact operators retain some of these characteristics but also diverge
in certain respects. The study explores the relationships between LM-compact operators and some existing classes,
and examines their algebraic properties and duality aspects.
Ruído ferroviário: tipos, descritores e método simplificado de previsão
Authors: Sá Orlando Ramos de , Moura Lis Silva de , Souza Elton Prestes de , Santos Marcelo Augusto Fazza dos , Mesquita Alexandre Luiz Amarante
Published: December 2024

O transporte ferroviário possui várias vantagens, tais como segurança e a alta capacidade de carga, sendo adequado para o escoamento de produtos dos setores agrícola e mineral. Por outro lado, possui também desvantagens como baixa flexibilidade e geração de ruído para as comunidades que serão cruzadas pelas ferrovias. Vários países têm desenvolvido suas normas regulamentadoras desse tipo de ruído, assim como modelos matemáticos de previsão do ruído ferroviário. Muitos desses métodos estão implementados em softwares comerciais para geração de mapas de ruído. Contudo, métodos mais simples podem ser usados para uma primeira avaliação do ruído a ser gerado por uma nova linha férrea. O presente estudo tem como objetivo rever os principais tipos de ruído ferroviários, seus descritores e avaliar um dos métodos analíticos simplificados para a estimativa da geração de ruído ferroviário, o método de Mestre e Wooten. Para essa avaliação aplica-se o método em casos reportados pela literatura. Como resultado, o método apresentou uma boa predição ao ruído gerado por trens de carga.
Biomarcadores celulares em doenças cardiovasculares: identificação e validação de biomarcadores celulares que podem prever a necrose de células cardíacas e auxiliar em diagnósticos precoces
Authors: Peixoto Junior José Rafael , Santos Samir da Conceição dos , Oliveira Adriana Medeiros de , Oliveira Vanusa Medeiros de , Tavares Nadir Pessoa , Álvares Nadja Danielly Soares Cabral , Alves Wilkerson Madson de Souza , Marques Wilsiane Vieira de Souza , Roque Maria Gisele dos Santos , Gonçalves Olga Silva Ribeiro , Gomes Alice Ribeiro , Pinheiro Miriã Vieira de Souza
Published: December 2024

A patogênese cardíaca representa um grave problema de saúde pública global, com as Doenças Cardiovasculares (DCV) sendo a principal causa de morte no Brasil. Fatores de risco como dislipidemia e hipertensão contribuem para o desenvolvimento da aterosclerose, um processo inflamatório que leva à obstrução das artérias. O presente estudo teve como objetivo identificar biomarcadores capazes de prever a progressão da DCV e auxiliar no diagnóstico precoce. Através de uma revisão da literatura, foram analisados os biomarcadores mioglobina, CK-MB e troponinas cardíacas. A mioglobina, embora seja um dos primeiros marcadores a se elevar após a lesão, apresenta baixa especificidade. A CK-MB, por sua vez, possui maior especificidade, mas sua elevação ocorre de forma mais tardia. As troponinas cardíacas, especialmente a TnI e a TnT, demonstraram ser os marcadores mais sensíveis e específicos para o diagnóstico do infarto agudo do miocárdio, tornando-se o padrão-ouro para essa condição. A identificação precoce de biomarcadores, como as troponinas, é crucial para a otimização do tratamento e a melhoria do prognóstico dos pacientes com doenças cardiovasculares.
Comunicação, cultura e identidade étnica: a campanha da conaq “coronavírus nos quilombos”
Authors: Freitas Samily Loures de , Oliveira Osvaldo Martins de
Published: December 2024

Este artigo propõe-se a um debate fundamentado na análise semiótica e/ou interpretativa do discurso social, focando em material publicitário produzido pela Coordenação Nacional de Articulação das Comunidades Negras Rurais Quilombolas (Conaq) em uma campanha de prevenção à Covid-19 da organização em sua rede social no Instagram. Deste modo, o artigo tem por objetivo interpretar os sentidos e significados produzidos pelos discursos sociais e políticos veiculados nesta campanha da Conaq. Devido às escolhas textuais e estéticas, identificou-se a campanha como uma comunicação étnica e cultural, de caráter educativo e político para um público específico, isto é, integrantes de comunidades quilombolas. Concluiu-se que a Conaq, em meio a crise sanitária, procurou desempenhar um papel social e político educativo específico para proteger a vida nas comunidades dos quilombos, que consistiu, segundo as narrativas veiculadas, em cuidar, resguardar e proteger a vida dos seus, principalmente pessoas idosas, que são consideradas as guardiãs dos saberes tradicionais dessas comunidades.
An examination of natural and synthetic tyrosinase inhibitors
Authors: Demirdiş Gizem
Published: December 2024

The enzyme responsible for this process is known as tyrosinase, which is sometimes referred to as polyphenol oxidase, monophenol oxidase, phenolase, or catecholase. It is present in humans, plants, microbes, and fungi. Melanin pigments, found in both plants and animals, require this enzyme as an essential component. Tyrosinase is present in animal creatures, particularly in the pigments of the skin, hair, and eyes. Tyrosinase can cause darkening in foods that is unrelated to their inherent color. Beverages such as fruit juice and wine may experience a decline in appearance and flavor, as well as the occurrence of turbidity and precipitation. The unwanted phenomenon of browning in fruits and vegetables, which is frequently caused by enzymatic processes, needs to be avoided. Tyrosinase enzyme inhibitors are employed to hinder the catalytic oxidations that lead to browning by the tyrosinase enzyme. Currently, these basic ingredients are commonly found in skin whitening solutions, particularly in the field of cosmetics. In addition, tyrosinase inhibitors have practical applications in the treatment of skin problems associated with melanin pigmentation. Furthermore, tyrosinase inhibitors competitively and reversibly hinder the activity of human melanocyte tyrosinase, hence impeding the production of melanin.Numerous substances possess the ability to hinder the activity of the enzyme tyrosinase. Ongoing studies are being conducted on several derivatized compounds to increase inhibition. This article explores the inhibitory effects of many compounds, including kojic acid, azelaic acid, flavonoids, arbutin-deoxyarbutin, curcumin and its derivatives, and copper chelators, on the enzyme tyrosinase.
Dataset koleksi anggrek: Eksplorasi flora Samosir, Sumatera Utara
Authors: Suminarsih Eka Meifrina , Puspitaningtyas Dwi Murti
Published: December 2024

Sumatra Island, with its tropical climate, provides an ideal habitat for orchid diversity. However, the rich diversity and potential of these orchids are increasingly threatened by high deforestation rates across Indonesia, leading to risks of reduction and even extinction. To address this, conservation activities are underway at the Samosir Botanic Garden. This study aimed to inventory the orchid diversity on Samosir Island. Collected orchids are being conserved as a living collection both ex situ at the Bogor Botanic Garden and in situ at the Samosir Botanic Garden. An exploratory method was used, resulting in a collection of 80 orchid specimens, representing 35 genera, 80 species, and 313 individual samples. These orchids were found at altitudes ranging from 989 to 1,799 meters above sea level and included 60 epiphytic species, 1 lithophytic species, and 19 terrestrial species. A total of 23 orchid species were identified during the exploration, and data on these species are stored in the National Scientific Repository (RIN). This repository provides a valuable resource for further research on the orchid species richness in Samosir Regency.
Reverse engineering modeling of jet turbine engine blade ring palisade geometry
Authors: Ułanowicz Leszek , Szczepaniak Paweł , Jastrzębski Grzegorz
Published: December 2024

When designing small turbine jet engines for UAVs, the theory of geometric similarity of components made at different scales can be used. This allows determining how an engine component designed at a macro scale can be recreated at a micro scale. The idea of the process of modeling the palisade of turbine blade rings of a UAV jet engine together with its rotor and nozzle blades, based on reverse engineering, is presented. The methodology for reproducing the geometry of turbine blade rings together with their rotor and nozzle blades of a turbine jet engine is presented. The tools for removing the geometry of turbine blade rings and their rotor and nozzle blades are characterized. The model creation algorithm was built for the Siemens NX system. The effect of model construction is presented in the form of a 3D printout of turbine blade rings and their rotor and nozzle blades. Reverse engineering allows for reproducing turbine components of jet engines at a macro scale and modeling their geometry at a micro scale. The proposed reverse engineering process can be successfully used to reconstruct turbine components of jet engines with even very complex shapes. The digital model obtained as a result of scanning was used for geometry modeling, but it can be successfully used for other analyses, studies or calculations, including modeling physical phenomena.