bluuebunny/crossref_metadata_2025 huggingface dataset:
Prediction of Wellness Condition for Community-Dwelling Elderly via ECG Signals Data-Based Feature Construction and Modeling
Authors: Zhao Yang , Xu Fan , Fan Xiaomao , Wang Hailiang , Tsui Kwok-Leung , Guan Yurong
Published: September 2022

The accelerated growth of elderly populations in many countries and regions worldwide is creating a major burden to the healthcare system. Intelligent approaches for continuous health monitoring have the potential to promote the transition to more proactive and affordable healthcare. Electrocardiograms (ECGs), collected from portable devices, with noninvasive and cost-effective merits, have been widely used to monitor various health conditions. However, the dynamic and heterogeneous pattern of ECG signals makes relevant feature construction and predictive model development a challenging task. In this study, we aim to develop an integrated approach for one-day-forward wellness prediction in the community-dwelling elderly using single-lead short ECG signal data via multiple-features construction and predictive model implementation. Vital signs data from the elderly were collected via station-based equipment on a daily basis. After data preprocessing, a set of features were constructed from ECG signals based on the integration of various models, including time and frequency domain analysis, a wavelet transform-based model, ensemble empirical mode decomposition (EEMD), and the refined composite multiscale sample entropy (RCMSE) model. Then, a machine learning based predictive model was established to map the l-day lagged features to wellness condition. The results showed that the approach developed in this study achieved the best performance for wellness prediction in the community-dwelling elderly. In practice, the proposed approach could be useful in the timely identification of elderly people who might have health risks, and could facilitating decision-making to take appropriate interventions.
The Complex Media Effects on Civic Participation Intention Amid COVID-19 Pandemic: Empirical Evidence from Wuhan College Students
Authors: Li Xueyan , Fu Ping , Li Min
Published: September 2022

In the context of the COVID-19 pandemic, media exposure is crucial to motivate public action for the combat with COVID-19 pandemic. However, media effects on civic participation intention are understudied. This study applied the Differential Susceptibility to Media effects Model (DSMM) to explore the relations among Wuhan college students’ media use, their pandemic-relevant beliefs, and civic participation intention, with a focus on the possible mediation of pandemic-relevant beliefs. Data of 4355 students from a large-scale cross-sectional survey were analyzed. Results show that traditional media use and online media interaction both directly and indirectly affect civic participation intention via pandemic-relevant beliefs. Pandemic-relevant beliefs distort the relations that direct and indirect effects of new media use on civic participation intention are significant but in opposite directions. The influence of pandemic news on civic participation intention is entirely mediated by pandemic-relevant beliefs. To conclude, during pandemic, the role of traditional media use is unreplaceable in its direct and indirect impact on civic participation intention. Pandemic-relevant beliefs play as a distorter variable. The balance between overexposure and insufficiency of pandemic-relevant news is vital. Online media interaction, as a main trait of new media use, plays a crucial role in civic participation intention, directly and indirectly.
The Joint Association of Daily Rest Periods and Sleep Duration with Worker Health and Productivity: A Cross-Sectional Web Survey of Japanese Daytime Workers
Authors: Ikeda Hiroki , Kubo Tomohide , Izawa Shuhei , Nakamura-Taira Nanako , Yoshikawa Toru , Akamatsu Rie
Published: September 2022

A daily rest period (DRP) is a daily inter-work interval that contains sleep opportunity. This study investigates the joint association of DRP and sleep duration with worker health and productivity. A total of 13,306 Japanese daytime workers participated in this web-based cross-sectional survey. Participants reported on their DRPs and sleep duration; moreover, sleep difficulties, mental health, and presenteeism were assessed by the standardized questionnaires. The participants were divided into 10 groups based on their DRPs and sleep duration. Logistic regression analyses showed that the combination of quick return (QR: DRP of <11 h) and short sleep duration (<6 h) was found to be significantly associated with sleep difficulties (odds ratio [OR] = 4.45, 95% confidence interval [CI] = 2.83–7.01), poor mental health (OR = 3.04, 95% CI = 1.79–5.15), and presenteeism (OR = 2.35, 95% CI = 1.47–3.77) compared with the reference group (the combination of adequate DRP [15 h] and a normal sleep duration [≥6 h]). The combination of QR and normal sleep duration or adequate DRP and short sleep duration was significantly associated with high ORs for the outcomes. QR, short sleep duration, or both negatively affect worker health and productivity.
Prevention from Sharp Injuries in the Hospital Sector: An Italian National Observatory on the Implementation of the Council Directive 2010/32/EU before and during the COVID-19 Pandemic
Authors: De Carli Gabriella , Agresta Alessandro , Lecce Maria Giuseppina , Marchegiano Patrizia , Micheloni Gianpaolo , Sossai Dimitri , Campo Giuseppe , Tomao Paola , Vonesch Nicoletta , Leone Sara , Puro Vincenzo ,   The Studio Italiano Rischio Occupazionale da HIV (SIROH) Group
Published: September 2022

Sharp injuries, determining the risk of bloodborne infections and psychological distress in healthcare workers, may be prevented by a set of strategies, legally enforced in Europe through the Directive 2010/32/EU. To assess its level of implementation in Italy, a national survey was conducted in 2017 and again in 2021, evaluating the progress and possible drawbacks of the COVID-19 pandemic. Altogether, 285 safety managers and 330 nurses from a representative sample of 97 and 117 public hospitals were interviewed using a standardized questionnaire. Knowledge of the Directive requirements decreased significantly, with <60% of participants answering correctly in 2021, and nurses’ attendance in specific courses dropped to 25% in 2021 compared to 54% in 2017. Over 75% of hospitals introduced multiple safety-engineered devices (SED), though total replacement occurred in <50% of cases; routine SED availability increased for blood collection (89%) and venous access devices (83%). Incorrect behaviors in handling sharps decreased significantly over time. Nurses’ HBV vaccination coverage was high (89% in both surveys); in the last year, 97% were vaccinated against COVID, and 47% against influenza. Average annual injuries per hospital did not increase significantly (32 in 2021 vs. 26 in 2017). In 2017, nurses’ perceived safety barriers were working in emergency situations (49%) and lack of resources (40%); in 2021, understaffing (73%), physical fatigue (62%), and handling difficulties while wearing full protective equipment (59%). Safety measures were implemented in Italian hospitals, and although the average injuries per hospital did not show a decrease, these measures could have helped protect healthcare workers during the pandemic, mitigating its potential impact on the increase in situations at risk of injury.
Low-Carbon Transition Models of High Carbon Supply Chains under the Mixed Carbon Cap-and-Trade and Carbon Tax Policy in the Carbon Neutrality Era
Authors: Shen Liang , Lin Fei , Cheng T. C. E.
Published: September 2022

To achieve the goals of carbon peak and carbon neutrality, the low-carbon transformation (LCT) of high-carbon firms is inevitable. We construct game models of a supply chain with different dominant types under a mixed carbon policy that embraces carbon cap-and-trade and carbon tax. Solving each dominant model, we derive the effective area and optimal threshold of the mixed carbon policy to guide LCT. We find that the selling price, market demand, and profit of the supply chain system are equal in different dominant models due to the mixed carbon policy, but when a company dominates the supply chain, its profit is higher than when it is a subordinate. In addition, the high-carbon manufacturers (HCM) will pursue LCT only when the sum of the carbon tax rates and carbon trading prices is within a certain threshold, and the subordinate HCM are more likely to be driven to pursue LCT. Therefore, the government should adopt a differentiated hybrid carbon policy, setting a high (low) carbon tax rate for the HCM in a dominant (subordinate) position.
Intention to Pay for Vaccination and Influencing Factors of General Residents: A National Cross-Sectional Study
Authors: Zhang Weixin , Shen Xin , Li Ting , Li Nan , Sun Yanyan , Zhu Siyu , Liu Nana , Song Huifang , Tang Kun , Wang Yujia , Zhang Ying , Cao Hui , Wu Yibo , Gan Yong , Zhang Xinyao
Published: September 2022

Background: As an important part of the promotion of immunization programs and the suppression of infectious diseases, paid vaccines can prevent a variety of diseases and meet the needs of different populations. However, few studies focus on the public’s intention to pay for vaccination. Methods: The survey was conducted from 10 July to 15 September 2021, adopting a cross-sectional survey in China. We used a multi-stage sampling strategy to recruit participators from 120 cities. Participants filled out questions which assessed their intentions to pay for vaccination. A linear regression analysis was given to identify the predictors associated with the subjects’ attitudes. Results: There were 11,031 residents who finished our questionnaire. Chinese residents’ intention to receive paid vaccines scored 74.5 points. Residents who were male (β = −0.03) and older (30–44 (β = −0.03) or 45–59 (β = −0.06) or ≥60 (β = −0.08)), living alone (β = −0.03), who had moderate to severe anxiety (β = −0.03) or severe anxiety (β = −0.03) were more likely to refuse vaccination, while those who lived in Western China (β = 0.03) who had higher PSSS scores and HLS-SF12 index might acquire the intention to pay for vaccination. Conclusions: The study found that gender, age, region, living alone, anxiety, social support, and health literacy were the main influencing factors of residents’ attitudes. Governments and health institutions should take targeted measures to improve the health literacy and mental health of the population in order to facilitate the implementation of vaccination withdrawal and immunization policies.
Oxidative Stress Markers and Sperm DNA Fragmentation in Men Recovered from COVID-19
Authors: Shcherbitskaia Anastasiia D. , Komarova Evgeniia M. , Milyutina Yulia P. , Ishchuk Mariia A. , Sagurova Yanina M. , Safaryan Galina K. , Lesik Elena A. , Gzgzyan Alexander M. , Bespalova Olesya N. , Kogan Igor Y.
Published: September 2022

SARS-CoV-2 negatively affects semen characteristics, impairs various biochemical processes in seminal fluid and within spermatogenic cells ultimately leading to male fertility decline. However, the distinct mechanisms, in particular, the role of oxidative stress on the consequences of coronavirus infection, have not been well investigated, which is the purpose of the present study. The standard semen parameters, its pro- and antioxidant system state, as well as the level of sperm DNA fragmentation, were assessed in 17 semen samples of men five months after the coronavirus infection and in 22 age-matched control patients. We determined that the DNA fragmentation rate negatively correlated with the period after coronavirus recovery, as well as seminal fluid superoxide dismutase activity and uric acid level. It was demonstrated that COVID-19 is not always associated with increased DNA fragmentation, allowing them to be considered as two independent factors. Thus, the most significant changes were noted in the samples of men after COVID-19 and abnormal TUNEL results: increased round cell number, decreased seminal fluid’s nitrotyrosine level, and total antioxidant capacity and Zn, as well as an increased 8-hydroxy-2′-deoxyguanosine level within spermatozoa. The data obtained indicate that increased DNA fragmentation and diminished semen quality in men can be the result of an imbalance in semen pro- and antioxidant components after COVID-19.
Prefrontal Cortical Control of Activity in Nucleus Accumbens Core Is Weakened by High-Fat Diet and Prevented by Co-Treatment with N-Acetylcysteine: Implications for the Development of Obesity
Authors: Morgan Carlos , Sáez-Briones Patricio , Barra Rafael , Reyes Andrea , Zepeda-Morales Katherine , Constandil Luis , Ríos Miguel , Ramírez Paulina , Burgos Héctor , Hernández Alejandro
Published: September 2022

A loss of neuroplastic control on nucleus accumbens (NAc) neuronal activity exerted by the medial prefrontal cortex (mPFC) through long-term depression (LTD) is involved in triggering drug-seeking behavior and relapse on several substances of abuse due to impaired glutamate homeostasis in tripartite synapses of the nucleus accumbens (NAc) core. To test whether this maladaptive neuroplastic mechanism underlies the addiction-like behavior induced in young mice by a high-fat diet (HFD), we utilized 28-days-old male mice fed HFD ad-libitum over 2 weeks, followed by 5 days of HFD abstinence. Control groups were fed a regular diet. HFD fed mice showed increased ΔFosB levels in the NAc core region, whereas LTD triggered from the mPFC became suppressed. Interestingly, LTD suppression was prevented by an i.p. injection of 100 mg/kg N-acetylcysteine 2.5 h before inducing LTD from the mPFC. In addition, excessive weight gain due to HFD feeding was diminished by adding 2mg/mL N-acetylcysteine in drinking water. Those results show a loss of neuroplastic mPFC control over NAc core activity induced by HFD consumption in young subjects. In conclusion, ad libitum consumption of HFD can lead to neuroplastic changes an addiction-like behavior that can be prevented by N-acetylcysteine, helping to decrease the rate of excessive weight gain.
Multiple Cell Cultures for MRI Analysis
Authors: Bober Zuzanna , Aebisher David , Olek Marcin , Kawczyk-Krupka Aleksandra , Bartusik-Aebisher Dorota
Published: September 2022

Magnetic resonance imaging (MRI) is an imaging method that enables diagnostics. In recent years, this technique has been widely used for research using cell cultures used in pharmaceutical science to understand the distribution of various drugs in a variety of biological samples, from cellular models to tissues. MRI’s dynamic development in recent years, in addition to diagnostics, has allowed the method to be implemented to assess response to applied therapies. Conventional MRI imaging provides anatomical and pathological information. Due to advanced technology, MRI provides physiological information. The use of cell cultures is very important in the process of testing new synthesized drugs, cancer research, and stem cell research, among others. Two-dimensional (2D) cell cultures conducted under laboratory conditions, although they provide a lot of information, do not reflect the basic characteristics of the tumor. To replicate the tumor microenvironment in science, a three-dimensional (3D) culture of tumor cells was developed. This makes it possible to reproduce in vivo conditions where, in addition, there is a complex and dynamic process of cell-to-cell communication and cell–matrix interaction. In this work, we reviewed current research in 2D and 3D cultures and their use in MRI studies. Articles for each section were collected from PubMed, ScienceDirect, Web of Science, and Google Scholar.
Neuropathology of the Basal Ganglia in SNCA Transgenic Rat Model of Parkinson’s Disease: Involvement of Parvalbuminergic Interneurons and Glial-Derived Neurotropic Factor
Authors: Paldino Emanuela , D’angelo Vincenza , Massaro Cenere Mariangela , Guatteo Ezia , Barattucci Simone , Migliorato Giorgia , Berretta Nicola , Riess Olaf , Sancesario Giuseppe , Mercuri Nicola Biagio , Fusco Francesca Romana
Published: September 2022

Parkinson’s disease (PD) is a neurodegenerative disease characterized by the accumulation of alpha-synuclein, encoded by the SNCA gene. The main neuropathological hallmark of PD is the degeneration of dopaminergic neurons leading to striatal dopamine depletion. Trophic support by a neurotrophin called glial-derived neurotrophic factor (GDNF) is also lacking in PD. We performed immunohistochemical studies to investigate neuropathological changes in the basal ganglia of a rat transgenic model of PD overexpressing alfa-synuclein. We observed that neuronal loss also occurs in the dorsolateral part of the striatum in the advanced stages of the disease. Moreover, along with the degeneration of the medium spiny projection neurons, we found a dramatic loss of parvalbumin interneurons. A marked decrease in GDNF, which is produced by parvalbumin interneurons, was observed in the striatum and in the substantia nigra of these animals. This confirmed the involvement of the striatum in the pathophysiology of PD and the importance of GDNF in maintaining the health of the substantia nigra.
Effects of Substitution Ratios of Zinc-Substituted Hydroxyapatite on Adsorption and Desorption Behaviors of Bone Morphogenetic Protein-2
Authors: Huang Baolin , Li Manchun , Mo Hailing , Chen Chuang , Chen Kun
Published: September 2022

Understanding interactions between bone morphogenetic proteins (BMPs) and biomaterials is of great significance in preserving the structure and bioactivity of BMPs when utilized in clinical applications. Currently, bone morphogenetic protein-2 (BMP-2) is one of the most important growth factors in bone tissue engineering; however, atomistic interactions between BMP-2 and zinc-substituted hydroxyapatite (Zn-HAP, commonly used in artificial bone implants) have not been well clarified until now. Thus, in this work, the interaction energies, binding/debinding states, and molecular structures of BMP-2 upon a series of Zn-HAP surfaces (Zn-HAPs, 1 at%, 2.5 at%, 5 at%, and 10 at% substitution) were investigated by hybrid molecular dynamics (MD) and steered molecular dynamics (SMD) simulations. Meanwhile, cellular studies including alkaline phosphatase (ALP) activity and reverse transcription-polymerase chain reaction (RT-PCR) assay were performed to verify the theoretical modeling findings. It was found that, compared to pure HAP, Zn-HAPs exhibited a higher binding affinity of BMP-2 at the adsorption process; meanwhile, the detachment of BMP-2 upon Zn-HAPs was more difficult at the desorption process. In addition, molecular structures of BMP-2 could be well stabilized upon Zn-HAPs, especially for Zn10-HAP (with a 10 at% substitution), which showed both the higher stability of cystine-knots and less change in the secondary structures of BMP-2 than those upon HAP. Cellular studies confirmed that higher ALP activity and osteogenic marker gene expression were achieved upon BMP-2/Zn-HAPs than those upon BMP-2/HAP. These findings verified that Zn-HAPs favor the adsorption of BMP-2 and leverage the bioactivity of BMP-2. Together, this work clarified the interaction mechanisms between BMP-2 and Zn-HAPs at the atom level, which could provide new molecular-level insights into the design of BMP-2-loaded biomaterials for bone tissue engineering.
Mechano-Transduction Boosts the Aging Effects in Human Erythrocytes Submitted to Mechanical Stimulation
Authors: Dinarelli Simone , Longo Giovanni , Francioso Antonio , Mosca Luciana , Girasole Marco
Published: September 2022

Erythrocytes’ aging and mechano-transduction are fundamental cellular pathways that determine the red blood cells’ (RBCs) behavior and function. The aging pattern can be influenced, in morphological, biochemical, and metabolic terms by the environmental conditions. In this paper, we studied the effect of a moderate mechanical stimulation applied through external shaking during the RBCs aging and revealed a strong acceleration of the aging pattern induced by such stimulation. Moreover, we evaluated the behavior of the main cellular effectors and resources in the presence of drugs (diamide) or of specific inhibitors of the mechano-transduction (probenecid, carbenoxolone, and glibenclamide). This approach provided the first evidence of a direct cross-correlation between aging and mechano-transduction and permitted an evaluation of the overall metabolic regulation and of the insurgence of specific morphological features, such as micro-vesicles and roughness alterations. Overall, for the first time the present data provided a schematic to understand the integration of distinct complex patterns in a comprehensive view of the cell and of its interactions with the environment. Mechano-transduction produces structural effects that are correlated with the stimulation and the strength of the environmental stimulation is paramount to effectively activate and trigger the biological cascades initiated by the mechano-sensing.
Juniperus sabina L. as a Source of Podophyllotoxins: Extraction Optimization and Anticholinesterase Activities
Authors: Xu Shengnan , Li Xinru , Liu Shi , Tian Peilin , Li Dengwu
Published: September 2022

Juniperus sabina L. (J. sabina) has been an important plant in traditional medicine since ancient times. Its needles are rich in podophyllotoxin, a precursor compound to anti-tumor drugs. However, no systematic research has been done on J. sabina as a source of podophyllotoxins or their biological action. Hence, extracts of podophyllotoxin and deoxypodophyllotoxin were the main optimization targets using the Box–Behnken design (BBD) and response surface methodology (RSM). The total phenol content and antioxidant activity of J. sabina needle extract were also optimized. Under the optimal process conditions (ratio of material to liquid (RLM) 1:40, 90% methanol, and ultrasonic time 7 min), the podophyllotoxin extraction rate was 7.51 mg/g DW, the highest level reported for Juniperus spp. distributed in China. To evaluate its biological potential, the neuroprotective acetyl- and butyrylcholinease (AChE and BChE) inhibitory abilities were tested. The needle extract exhibited significant anti-butyrylcholinesterase activity (520.15 mg GALE/g extract), which correlated well with the high levels of podophyllotoxin and deoxypodophyllotoxin. This study shows the potential medicinal value of J. sabina needles.
Pincer Complexes Derived from Tridentate Schiff Bases for Their Use as Antimicrobial Metallopharmaceuticals
Authors: Aragón-Muriel Alberto , Reyes-Márquez Viviana , Cañavera-Buelvas Farrah , Parra-Unda Jesús R. , Cuenú-Cabezas Fernando , Polo-Cerón Dorian , Colorado-Peralta Raúl , Suárez-Moreno Galdina V. , Aguilar-Castillo Bethsy Adriana , Morales-Morales David
Published: September 2022

Within the current challenges in medicinal chemistry, the development of new and better therapeutic agents effective against infectious diseases produced by bacteria, fungi, viruses, and parasites stands out. With chemotherapy as one of the main strategies against these diseases focusing on the administration of organic and inorganic drugs, the latter is generally based on the synergistic effect produced by the formation of metal complexes with biologically active organic compounds. In this sense, Schiff bases (SBs) represent and ideal ligand scaffold since they have demonstrated a broad spectrum of antitumor, antiviral, antimicrobial, and anti-inflammatory activities, among others. In addition, SBs are synthesized in an easy manner from one-step condensation reactions, being thus suitable for facile structural modifications, having the imine group as a coordination point found in most of their metal complexes, and promoting chelation when other donor atoms are three, four, or five bonds apart. However, despite the wide variety of metal complexes found in the literature using this type of ligands, only a handful of them include on their structures tridentate SBs ligands and their biological evaluation has been explored. Hence, this review summarizes the most important antimicrobial activity results reported this far for pincer-type complexes (main group and d-block) derived from SBs tridentate ligands.
Photodiode Read-Out System for the Calorimeter of the Herd Experiment
Authors: Betti Pietro , Adriani Oscar , Antonelli Matias , Bai Yonglin , Bai Xiaohong , Bao Tianwei , Berti Eugenio , Bonechi Lorenzo , Bongi Massimo , Bonvicini Valter , Bottai Sergio , Cao Weiwei , Casaus Jorge , Chen Zhen , Cui Xingzhu , D’Alessandro Raffaello , Detti Sebastiano , Dong Yongwei , Finetti Noemi , Formato Valerio , Frutos Miguel Angel Velasco , Gao Jiarui , Liang Xiaozhen , Li Ran , Liu Xin , Lyu Linwei , Martinez Gustavo , Mori Nicola , Munoz Jesus Marin , Pacini Lorenzo , Papini Paolo , Pizzolotto Cecilia , Quan Zheng , Qin JunJun , Shi Dalian , Starodubtsev Oleksandr , Tang Zhicheng , Tiberio Alessio , Vagelli Valerio , Vannuccini Elena , Wang Bo , Wang Junjing , Wang Le , Wang Ruijie , Zampa Gianluigi , Zampa Nicola , Wang Zhigang , Xu Ming , Zhang Li , Zheng Jinkun
Published: September 2022

HERD is a future experiment for the direct detection of high energy cosmic rays. The instrument is based on a calorimeter optimized not only for a good energy resolution but also for a large acceptance. Each crystal composing the calorimeter is equipped with two read-out systems: one based on wavelength-shifting fibers and the other based on two photodiodes with different active areas assembled in a monolithic package. In this paper, we describe the photodiode read-out system, focusing on experimental requirements, design and estimated performances. Finally, we show how these features lead to the flight model project of the photodiode read-out system.
Performance Study of a New Cluster Splitting Algorithm for the Reconstruction of PANDA EMC Data
Authors: Zhang Ziyu , Zhao Guang , Sun Shengsen , Pu Qing , Liu Chunxiu , Yu Chunxu , Liu Dong , Qi Hang , Huang Guangshun , Stockmanns Tobias , Liu Beijiang , Wang Fei , Zhang Yitong , Shen Xiaoyan
Published: September 2022

For high-energy π0 mesons, the angle between the two final-state photons decreases with the increase in the energy of the π0, which enhances the probability of overlapping electromagnetic showers. The performance of the cluster splitting algorithm in the EMC reconstruction is crucial for the mass resolution measurement of π0 with high energy. The cluster splitting algorithm is based on the theoretical lateral distribution of the electromagnetic showers. A simple implementation of the lateral distribution can be described as a (multi-)exponential function. In a realistic electromagnetic calorimeter, considering the granularity of the detector, the measured energy in a cell is actually the integral of the theoretical energy deposition, which deviates from the exponential function. Based on the simulation of the barrel EMC in the P¯ANDA experiment, a cluster splitting algorithm with a new lateral energy development function is developed. The energy resolution of overlapping showers with high energy has been improved.
Research and Development of the Combined Cycle Power Plants Working on Supercritical Carbon Dioxide
Authors: Rogalev Andrey , Rogalev Nikolay , Kindra Vladimir , Komarov Ivan , Zlyvko Olga
Published: September 2022

Today, the use of combined cycle gas turbine (CCGT) plants allows the most efficient conversion of the chemical heat of fossil fuels for generating electric power. In turn, the combined cycle efficiency is largely dependent on the working flow temperature upstream of a gas turbine. Thus, the net electric efficiency of advanced foreign-made CCGT plants can exceed 63%, whereas the net efficiency of domestic combined-cycle power plants is still relatively low. A promising method to increase the heat performance of CCGT plants may be their conversion from a steam heat carrier to a carbon dioxide one. In this paper, we have presented the results of thermodynamic research of a promising combined plant with two carbon dioxide heat recovery circuits based on the GTE-160 gas turbine plant (GTP). We have determined the pressure values that are optimal in terms of the net efficiency upstream and downstream of Brayton cycle turbines using supercritical carbon dioxide with recompression (30 and 8.5 MPa) and base version (38 and 8.0 MPa). The percentage of recompression was 32%. Based on the results of mathematical simulation of heat circuits, we have found out that the use of the solutions suggested allows the increase of the power plant’s net efficiency by 2.4% (up to 51.6%).
Calidad de servicio y satisfacción de los usuarios en bibliotecas públicas municipales del sur del Perú
Authors: Mamani Quispe Katy del Rosario , Vilca Colquehuanca Gustavo Luis
Published: September 2022

Las bibliotecas municipales son espacios públicos donde los ciudadanos pueden leer y consultar diversas fuentes bibliográficas. En la región Puno, al sur del Perú, estos espacios enfrentan desafíos internos y externos que hace difícil su funcionamiento y posibilidad de generar valor público. En este contexto el objetivo de este estudio fue determinar la relación entre la calidad del servicio y satisfacción de los usuarios de las bibliotecas públicas en las municipalidades provinciales de la región Puno. La metodología corresponde a un enfoque cuantitativo, de alcance correlacional, diseño no experimental y de corte transeccional. El estudio comprende al total de bibliotecas municipales provinciales que funcionan en el ámbito de estudio (11 bibliotecas). La muestra estuvo constituida por 368 usuarios que hacen uso de los servicios ofertados. Para la recolección de datos se aplicaron dos instrumentos: el primero, midió la calidad de servicio mediante la guía de autodiagnóstico de la Norma Técnica para la gestión de la calidad de servicios en sector público; y el segundo, la escala del modelo LIBQUAL para medir la satisfacción de usuarios de las bibliotecas. Los resultados reportan que nueve (09) de las once (11) bibliotecas municipales se encuentran en un nivel bajo (I y II) respecto al grado de cumplimiento de los componentes de la Norma Técnica, mientras que las bibliotecas de Puno y Moho alcanzaron un nivel III. Respecto a la satisfacción de los usuarios, ésta aún es baja. Por ello, no se halló evidencia de una correlación significativa entre la calidad de servicio y satisfacción en los usuarios.
Reinterpretasi Hadis Larangan Perempuan Bepergian Tanpa Mahram dan Larangan Melukis (Pendekatan Sosio-Historis dan Antropologis))
Authors: Hamzah Ghufron
Published: September 2022

This article focuses on the interpretation of the prohibition of women traveling without mahram hadith and the prohibition on writing which is often understood textually as the editors of the hadith. The literature review method with descriptive qualitative analysis through contingent analysis of the perspective of the socio-historical and anthropological approaches used in this article. The findings of this study are: (1) The legislation of the ban on women traveling alone if they look at the historical context of the above hadith is security and propriety, the current contextualization is if the security of women traveling alone is guaranteed and women are deemed appropriate more taboo when traveling alone, it does not matter if women travel alone without mahram, (2) Rationes legis from prohibiting the painting of animate creatures, namely the fear of the emergence of shirk by worshiping paintings or sculptures as in the time of ignorance. This prohibition in the concept of usul fiqh can be categorized as sadd al-dzari'ah which is to cut the path of damage (mafsadah) as a way to avoid such damage, in other words it is an anticipatory step.
Pendidikan Karakter Berbasis Aswaja di MA Amsilati Bangsri Jepara
Authors: Subaidi Subaidi
Published: September 2022

This research described about character education aswaja based at the madrassa aliyah amsilati bangsri jepara.This study using the kind of qualitative. descriptive approachThe research is madrasah aliyah amsilati bangsri jepara.Data collection techniques using interviews, observation and documentation. While the data analysis techniques is interactive consisting of 3 components, data which is the reduction of the presentation of data and the withdrawal of. conclusionThis research result among others: first pembiasaan relegius.characterIt means, anak-anak in the neighborhood madrasah aliyah amsilati bangsri jepara has run nilai-nilai based character aswaja like: al-muj hadah, mahabatullah love of god And praise to god , mudarasatulqur an, which can maintain a harmony with the development of nation character as: character relegius , discipline , and friendly .Second, character education spirit nationality and love of the land water it means students dilingkungan madrasah aliyah amsilati bangsri have the nationality character that is a way of thinking , act , and insightful who puts the national interest and countries up our and the group.
Penerapan Model Pembelajaran Probing-Promting Terhadap Prestasi Belajar Peserta Didik Pada Mata Pelajaran Fiqih Kelas XI di MAN 1 Wonosobo
Authors: Arifianto Kevin , Imron Ali
Published: September 2022

This study aims to 1) find out the application of the probing-promting learning model in fiqh subjects in class XI at MAN 1 Wonosobo; 2) Knowing the increase in student achievement after using the probing-promting learning model in fiqh subjects for class XI at MAN 1 Wonosobo; 3) Knowing the difference in learning achievement using the probing-promting learning model with those using the conventional learning model.The approach uses a quasi-experimental method, using a nonequivalent control class pretest posttest design. The subjects in this study were taken into two classes, namely the experimental class and the control class. Before the second lesson, the class was given a pretest question. Experimental class students were given learning using the example of probing-promting learning, while the control class used conventional learning models. The experimental class and the control class were subjected to a final test in the form of a written test. then the results are processed, analyzed, and distributed using the t-test and gain test to find out the difference between the two classes studied and the increase in learning achievement.The impact of the research conveys that in PAI learning, students who use the example of probing-promting learning in this study have increased. This is shown using the gain test for the experimental class, which will be 0.618. and there are differences in the fiqh learning of students who are taught to use the probing-promting learning model using students who are not taught to use the probing-promting learning model. This is evidenced by using the t-test tcount > ttable both at the 1% significance level, which is 3.21 > 2.676. Meanwhile, at the 5% significance level, the t table is 2,008.
Current Issues in the Implementation of the System of Environmental-Economic Accounting
Authors: Laykam K. E. , Klevakina M. P. , Repin I. A.
Published: September 2022

The article outlines the international standard, System of Environmental-Economic Accounting (SEEA) – Central Framework, adopted by the UN in 2015 as the basis for developing 23 indicators of the Sustainable Development Goals. Statistical data from SEEA accounts provide the comprehensive assessment of environment, help identify trends and consequences of human impact on nature, serve as a tool for the formation and implementation of environmental policy in general, and help in monitoring the implementation of international obligations and recommendations including sustainable development areas.A separate section of the article covers specific features of SEEA implementation in selected countries of the world. There is an elaborate reflection of the work on the introduction of this standard to the Russian Federation, carried out by the Federal State Statistics Service. The authors believe that the need for a certain sequence of actions associated with the development and implementation of SEEA accounts gives impetus (in the short term) for the application of priority accounts, guided by the roadmap for the SEEA priority accounts implementation, approved by the order of the Government of the Russian Federation. The information base built using these accounts is necessary for conducting international comparisons, calculations of SDG indicators and green economy indicators.
Formação e desenvolvimento profissional docente
Authors: Sousa Roseline Martins Sabião
Published: September 2022

Este estudo desenvolveu-se na linha de pesquisa Desenvolvimento Profissional, Trabalho Docente e Processo de Ensino – Aprendizagem  do  Programa de Pós-Graduação em Educação  da Universidade de Uberaba – UNIUBE, tendo como ponto de partida compreender as concepções de formação de professores, na perspectiva da importância da formação e desenvolvimento profissional : o constituir-se professor e o conceito de formação de professores, atividade proposta da disciplina Formação e Desenvolvimento Profissional Docente. Entende-se que o processo de formação é contínuo uma vez que a Educação é inacabada, vivemos o mundo das incertezas e ao longo desse período pandêmico o que ficou mais claro foi a necessidade da inovação na Educação, do humanismo e práticas pedagógicas que envolvam o aluno dentro de sala de aula, fazendo com que ele desenvolva sua autonomia, percepção do ambiente escolar, interação com colegas e participação ativa nas atividades propostas pelo professor. Para tanto, o profissional docente é um artista que renova suas ideias na arte do saber fazer e ensinar, constituir-se é promover encontro de saberes, estudo, pesquisa, aulas diferenciadas, inovadoras, usar a tecnologia e claro resgatar valores sociais através da discussão e interpretação de temas transversais abordados nas aulas. Ponto de extrema importância a ser referenciado neste estudo também, diz respeito às competências e habilidades necessárias ao professor no tratamento com os alunos, isto é, domínio dos conteúdos, da didática e conhecer sobre o contexto em que o aluno está inserido, pode facilitar o preparo das aulas e o alcance dos objetivos pretendidos na formação do sujeito social. Objetivou-se neste estudo, contribuir de maneira significativa para a reflexão sobre o processo ensino - aprendizagem, pois, atualmente na área da Educação, depreende-se discussões referentes aos conhecimentos específicos, pedagógicos e tecnológicos e é exigido da atividade profissional docente exercer um ofício voltado para competências e habilidades, com atitudes, práticas, pedagógicas e inovadoras. A metodologia do desenvolvimento deste estudo seguiu uma abordagem qualitativa, leitura e análise da bibliografia indicada pela disciplina Formação e Desenvolvimento Profissional Docente, debate nas aulas síncronas, discussão dos textos a partir da elaboração de conceitos dos professores sobre as concepções de formação de professores, analisando os processos de ensino-aprendizagem dentro de cada atividade proposta. Portanto, espera-se com este estudo propiciar a ampliação da discussão sobre as concepçõe de formação de professores, no que se refere ao profissional técnico, reflexivo, pesquisador, intectual crítico e por fim o profissional colaborativo e suas repectivas tendências na aprendizagem.
Colicistite aguda alitiásica condutas que reduzem a taxa de internação em Terapia de Unidade Intensiva: uma revisão sistemática
Authors: Toqueton Tainá Rodrigues , Silva Alinne Freitas , Lobato Michele Silva , Farias Mateus Gutemberg Barbosa de , Coelho Pedro Henrique Oliveira Lima , Takahashi Bruna de Lucca Facholli , Xavier Thiago Antônio Rodrigues , Vasconcelos Anna Laura Costa , Moreno Marianna Endres , Bretas Júlia Lessa , Rangel Luis Felipe Scampini Siqueira , Silva Lucas Dantas Daniel , Silva Fernanda Pinheiro Quadros e , Toledo Caio de Almeida Sanches , Corrêa Amanda Cristina Quintela , Manica Franciele , Prudêncio Marina Álvares , Domingos Patrick Romero , Gontijo Luciana Monteiro , Magalhães Luana Oliveira , Ribeiro Caroline Macedo , Flores Juliane Lobato , Mouawad Isadora Hoff , Sales Felipe de Castro Dantas , Santos Lara de Sousa , Salvador Katarina Nunes , Sá Gabriela Fernanda de , Moreira Francielly Viana , Alves Karen Gandolfo da Costa
Published: September 2022

Os cálculos biliares se encontram em mais de 10% da população mundial, sendo que esta incidência se torna maior com o avanço da idade. Sendo assim a colecistite pode ser considerada como uma emergência comum no mundo, sendo que na maior parte dos casos é decorrente da inflamação da parede interna da vesícula devido á impactação do cálculo e decorrente obstrução no ducto cístico, produzindo assim dor repentina e aguda, entretanto a colecistite aguda alitiásica ocorre sem que haja cálculos em seu interior. Esse trabalho possui como sua pergunta de pesquisa qual conduta deve ser adotada para reduzir a taxa de internação em UTI’s em pacientes que apresentem colicistite aguda alitiásica. E assim como seu objetivo geral demonstrar a conduta adequada para manejo de pacientes que apresentem colicistite aguda alitiásica. E como seus objetivos específicos: Identificar do que se trata um quadro de colicistite aguda alitiásica; Auxiliar na tomada de conduta pelos profissionais acerca do tratamento adequado; Disponibilizar informações acerca do assunto. Esse trabalho trata-se de uma revisão sistemática de artigos extraídos das plataformas do PubMed, BVS, Lilacs, Medline, Scielo, esses que possuem datas dos últimos 5 anos e escritos nos seguintes idiomas: português, inglês e espanhol. Com isso conclui-se que ainda são escassos os estudos acerca do tema, portanto é necessário que os médicos consigam de forma significativa o diagnóstico com agilidade, e para isso o conhecimento sobre assunto por uma equipe multidisciplinar deve ser amplamente desenvolvido.
Physicochemical assessment of an orabase formulation of Libidibia ferrea L
Authors: Melo Luciana Aleixo dos Santos de , Toda Carina , Souza Tatiane Pereira , Matos Anselmo Junio Pedroso , Santos Liliane Lisboa da Costa , Sabelli Keily da Silva Melo , Bandeira Maria Fulgência Costa Lima , Conde Nikeila Chacon de Oliveira
Published: September 2022

The aim of the study was to control the physicochemical quality of an orabase formulation of L. ferrea L. An experimental, in vitro, controlled study was carried out as follows: centrifuge tests, pH, density, rheological behavior at room temperature (25.0 ± 2.0 °C), microbiological control by determining the total number of aerobic microorganisms, yeast growth, and organoleptic characteristics. The storage conditions were as follows: light room (±25.9°C), dark room (±28.8°C), refrigerator (± 2 to 8°C), and the experimental periods were 0, 30 and 60 days. In the centrifuge test, the separation of 1 oily phase (liquid and transparent) was observed in all storage conditions and times tested; in the pH test, the formulation remained stable with pH variations between 6.01 and 6.67, but there was no statistically significant difference at all times and conditions tested. The rheological behavior in terms of viscosity revealed that time and storage conditions did not alter the samples and the mean standard values related to rotation were 6 mPa.SNa (5111.9 ±11), 12 mPa.S (2555.2 ±7), 30 mPa.S (1023.9 ±2) and 60 mPa.S (512.5 ±4). The assessment of contaminants revealed no growth of contaminants in the storage conditions and times tested. As for the organoleptic characteristics, the samples showed no changes throughout the time and storage conditions. The formulation is physically and chemically stable under all storage conditions and times tested, proving to be suitable for extemporaneous formulations.
Uma reflexão acerca da (des) conhecida educação escolar indígena no Brasil
Authors: Bueno Cristiane Aparecida Ribeiro , Dossena Gisele Aparecida , Scolaro Julian Monike Nazario , Martini Emanuelle Luana , Corrêa Rosane Aparecida Brandalise , Carvalho Marco Antonio Batista
Published: September 2022

O presente artigo procura refletir como ocorreu a estruturação da educação escolar indígena no Brasil e como esta se expressa na Legislação Brasileira no contexto pós Constituição Federal de 1988, que regulamentou o direito social e educacional dos indígenas. Nesta direção, nossa análise centrou-se em compreender como a legislação educacional se organiza e se estrutura na efetiva prática da educação escolar para o povo indígena. A partir dos estudos centrados na Constituição Federal Brasileira (1988), na Lei de Diretrizes e Bases da Educação Nacional 9.394 (1996), no Referencial Curricular Nacional para as Escolas Indígenas (1998) e no documento Diretrizes Curriculares Nacionais para a Educação Escolar Indígena na Educação Básica (2012), se pode atestar que há sim um discurso em prol não só do compromisso com políticas públicas que atendam a essa minoria, mas com projetos e ações legais que viabilizaram garantias ao processo de escolarização de indígenas, contudo, os próprios documentos atestam um distanciamento das lideranças indígenas das discussões e, principalmente, da tomada de decisões que os envolvem.
Caracterização do ambiente térmico de criação de vacas em lactação no alto sertão sergipano
Authors: do Vale Patricia de Azevedo Castelo Branco , Do Vale Welington Gonzaga , Barreto Lígia Maria Gomes , Ribeiro Junior Valdir , Cabral Ana Maria Duarte , Brêtas Anilce De Araújo , Dos Santos Eduardo Jose , Cardoso Vinício dos Santos
Published: September 2022

A fim de caracterizar o ambiente térmico de criação de vacas leiteiras, no município de Nossa Senhora da Glória/Sergipe, foi realizado um trabalho em propriedade comercial, com 16 vacas da raça Girolando. As vacas foram separadas em dois piquetes, ambos com área de exposição ao sol e à sombra. Foram monitoradas remotamente as variáveis climáticas de temperatura, umidade relativa e temperatura do globo negro, pelo uso de um equipamento automatizado, desenvolvido pelo Departamento de Engenharia da UFS/São Cristóvão. A partir de tais dados, foram calculados o índice de temperatura e umidade (ITU) e o índice de temperatura do globo e umidade (ITGU). Estes valores então foram utilizados para comparação com as condições ideais de conforto térmico para bovinos leiteiros, de acordo com os sugeridos pela literatura. Para analisar os valores dos índices de conforto térmico será utilizada a carta de controle individual, que é uma das ferramentas do Controle Estatístico de Processo (CEP). As cartas de controle serão elaboradas utilizando o programa Minitab 19. De acordo com os resultados obtidos para ITGU, apenas os períodos da madrugada e noite apresentaram condições ambientais ideais para criação de bovinos leiteiros, nos demais períodos da manhã e tarde os animais passavam por estresse térmico de nível leve a situação de perigo. Com relação ao ITU os valores demonstraram-se insatisfatórios em relação aos da literatura.