bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALISIS PELAKSANAAN SISTEM MANAJEMEN MUTU BERBASIS INTERNATIONAL ORGANIZATION FOR STANDARDIZATION (ISO) 9001:2008 DI SMK NEGERI 3 JAYAPURA
Authors: Martza  , Tanta  , Kusdianto
Published: April 2023

Penelitian ini bertujuan untuk menganalisis pelaksanaan (1) Prosedur Manajemen Mutu berbasis ISO 9001:2008; (2) Tanggung jawab manajemen berbasis ISO 9001:2008; (3) Pengelolaan sumber daya berbasis ISO 9001:2008; (4) Faktor pendukung dan faktor kendala sistem manajemen mutu berbasis ISO 9001:2008. Jenis penelitian ini adalah deskriptif kualitatif dengan pendekatan studi kasus. Penelitian ini dilakukan di SMK Negeri 3 Jayapura. Sumber data dalam penelitian ini adalah Kepala Sekolah, Wakil Manajemen Mutu, Kepala Tata Usaha, Wakasek Kurikulum, Wakasek Humas, Wakasek Kesiswaan, Wakasek Sarpras, Kepala Tata Usaha, Ketua Jurusan, Guru. Instrumen penelitian adalah peneliti sendiri yang dilengkapi dengan pedoman wawancara, pedoman observasi dan pedoman dokumentasi. Teknik analisis data yang digunakan dalam penelitian ini adalah analisis data kualitatif mengikuti konsep Miles dan Huberman (1992) antara lain reduksi data, display data dan verifikasi/kesimpulan. Teknik keabsahan data menggunakan triangulasi data. Hasil penelitian menunjukkan bahwa (1) Prosedur manajemen mutu berbasis ISO 9001:2008 di SMK Negeri 3 Jayapura telah dilaksanakan. Hal ini dapat diketahui dengan pencapaian sasaran mutu sekolah yang tergolong berhasil. Selain itu, pelaksanaan Sistem Manajemen Mutu (SMM) ISO 9001: 2008 untuk masing-masing komponen berhasil dengan perolehan sertifikat ISO 9001:2008 dari SAI GLOBAL; (2) Tanggung jawab manajemen berbasis ISO 9001:2008 di SMK Negeri 3 Jayapura berhasil dilaksanakan. Hal ini dapat dilihat dari komitmen manajemen, fokus pada pelanggan, kebijakan mutu serta tanggung jawab dan komunikasi dilakukan dengan melakukan Audit mutu internal dan eksternal secara berkala; (3) Pengelolaan sumber daya berbasis ISO 9001:2008 di SMK Negeri 3 Jayapura tergolong berhasil hal ini dapat terlihat pada Sumber daya fisik, SDM yang mendukung, prasarana yang lengkap serta lingkungan kerja yang nyaman; (4) Faktor pendukung keberhasilan SMM ISO 9001:2008 SMK Negeri 3 Jayapura, yaitu: a) Komitmen dan Kesadaran dari semua Warga Sekolah, b) Kualitas SDM, c) Sarana Prasarana yang Memadai. Faktor kendala pelaksanaan Sistem Manajemen Mutu ISO 9001:2008 antara lain keterbatasan biaya di dalam kelanjutan Kerjasama dengan Perusahaan SAI GLOBAL yang menerbitkan sertifikat ISO 9001:2008, pelanggaran tata tertib sekolah baik guru maupun siswa, sosialisasi pelaksanaan Sistem Manajemen Mutu ISO 9001:2008, penulisan dokumen-dokumen di area kerja belum sesuai dengan instruksi kerja (IK), kurangnya dokumen rekaman di dalam setiap kegiatan.
AKREDITASI SEBAGAI PERTANGGUNGJAWABAN INSTITUSI TERHADAP STAKEHOLDER
Authors: Samodra Touvan , Sesilia Seli  , Lily Thamrin  , Asriah Nurdini Mardiyaningsih  , Uray Gustian  , Rio Pranata  , Dwi Riyanti  , Putri TipaAnasi  , Dian Miranda
Published: April 2023

Higher education's internal quality assurance system (IQAS) has regulated both the mechanism and the final achievement. To provide quality educational services, one of the pieces of evidence is the existence of an accreditation level status. The accreditation level status results from a quality culture reflected in good reporting following the planned conditions and achievements achieved. This effort is not wholly running smoothly. The change of different criteria in the output-based BAN-PT Accreditation is a challenge that forces a change in work patterns and reporting. Availability of standards, output targets, and outputs must be measurable in each criterion. Several things are still obstacles, so that the implementation of IQAS is significantly related to achievement standards, ease of accessing information, and document renewal which must adjust changes to the nine criteria. IQAS's efforts were carried out as preparation for external quality assurance as an institution's accountability to stakeholders.
Fungsi Ritual Barong Nguying di Desa Adat Bebalang Kecamatan Bangli Kabupaten Bangli
Authors: Asmariani Anak Agung Raka
Published: April 2023

Barong Ngunying is one form of Barong dance from many forms and types of Barong dance. Besides Ngunying, Barong also usually begins with a sequence of religious rituals followed by Bapang Barong dance. After Bapang Barong dance is performed, it is assembled withPanglembar dance by taking the Barong Swari play. As the main performance of the event from Barong Ngunying is the meeting between Barong and Rangda which symbolizes the meeting of PurushaPradhana which gives rise to PancaMahaButha. The Panca Maha Butha comes from the sacred power of Barong and Rangda, and furtherget into the human body. This condition causesa Trance which be marked by dancing like a drunken person, namely srayang-sruyung or screaming hysterically, and do not use Balinese dance standards. By performing out the Barong Ngunying ritual, the people of Desa Pakraman Bebalang are protected from calamity and pest until now. This study discusses two problems, including:  1) What is the What is the function of the Barong Ngunying ritual? This research uses   theory of religion. This research concludes that the function of the Barong Ngunying ritual is divided into social function, religious function, and aesthetic function.
Efektivitas Ngaben Kremasi di Krematorium Bebalang Bangli
Authors: Mahasutra I Ketut Gede Pringgatama Bintang , Ariputra I Putu Suyasa
Published: April 2023

This research is motivated by the condition of Balinese society which is increasingly modern with the influence of technology so that it has an impact on Balinese traditions and culture, especially the Ngaben Ceremony. Currently, conventional cremation ceremonies have been replaced with cremation cremations through crematoriums, one of which is the crematorium in the Bangli area, namely the Bebalang Crematrium. The crematorium cremation, which has many differences, raises questions about how effective the implementation of the crematorium cremation is and how the Pakraman village responds to the new tradition. This study also reveals the various reasons people have for holding a crematorium cremation ceremony. The purpose of the study was to determine the effectiveness of the Ngaben crematorium and the response of the Pakraman village in responding to changes in the Ngaben tradition. The research uses qualitative methods with a phenomenological approach, data collection through interviews, observations and literature studies. The results obtained in the study are that crematorium cremations are effective to be carried out in today's modern era which requires everything to be practical and efficient, Pakraman village The reason people choose to do Ngaben in the crematorium is also based on several factors including socio-cultural factors, social structure factors, factors economy, labor and time factors as well as certain condition factors in a region. So far, the awig-awig prevailing in Pakraman village does not limit the existence of crematorium cremations and the ceremony is adjusted to the times, not because an individual is subject to customary sanctions or other things. In carrying out the crematorium cremation, the Pakraman village community is also invited to attend as a symbol of harmony and maintain good relations between individuals and the community so as to minimize the risk of offence or misunderstanding.
AGAMA HINDU: SEBAGAI PEDOMAN, PANDANGAN DAN JAMINAN HIDUP
Authors: Putu Dana Yasa
Published: April 2023

Agama Hindu dengan berbagai sumber teologi yang tertuang dalam kitab suci Veda telah memberikan pembelajaran penting dalam menjalani kehidupan dan memahami hakikat kehidupan manusia sehingga mampu mencapai penyatuan dengan Tuhan. Agama Hindu dengan segala ajarannya idealnya mampu digunakan sebagai pedoman (tuntunan) dalam menjalani kehidupan serta memberikan pemahaman pandangan kehidupan universal sehingga mampu menyadari dan menerima seluruh realitas kehidupan yang ada. Saat agama Hindu dengan segala sumber ajarannya telah dipahami dan diterapkan dalam kehidupan, maka secara tekstual maupun kontekstual akan mendapat jaminan kehidupan yang lebih baik pada kehidupan berikutnya. Peningkatan kualitas kehidupan secara bertahap akan mengantarkan umat Hindu mencapai penyatuan dengan Tuhan dan menghentikan perputaran penderitaan kelahiran dan kematian berulang-ulang.
Keutamaan Ilmu Pengetahuan dalam Kakawin Puja Saraswati
Authors: Kadek Dedy Herawan
Published: April 2023

Secara umum dalam Agama Hindu antara Kebijaksanaan dan pengetahuan menunjukkan hubungan yang sangat dekat. Kedua istilah tersebut terutama digunakan sebagai aspek yang berhubungan dengan pembelajaran. Hubungannya dapat bersifat kausalitas maupun menunjukkan konfirmasi. Pada hubungan kausalitas setiap proses pembelajaran dinyatakan harus menghasilkan kebijaksanaan. Sementara pada hubungan konfirmasi apabila kebijaksanaan tidak tercapai dalam proses pembelajaran maka proses tersebut harus ditata ulang. Secara mitologis maupun filosofis pengetahuan aspek pengetahuan dalam Agama Hindu ditujukan dengan figur Saraswati. Sang Dewi canti yang merupakan permaisuri Dewa Brahma merupakan pengikat teologis bagi kearifan seluruh wujud ilmu pengetahuan. Hal ini bertentangan dengan pandangan kaum hedonis atau materialis yang cenderung memisahkan antara kebijaksanaan dan ilmu pengetahuan. Kebijaksanaan bagi golongan semacam itu dinyatakan hanya melibatkan dosis perspektif yang sehat dan kemampuan untuk membuat penilaian yang baik tentang suatu subjek sementara pengetahuan hanyalah mengetahui. Semua orang dapat menjadi berpengetahuan tentang suatu subjek dengan membaca, meneliti, dan menghafal fakta. Meskipun demikian kebijaksanaan disebut-sebut membutuhkan lebih banyak pemahaman dan kemampuan untuk menentukan fakta yang relevan dalam situasi tertentu. Kebijaksanaan selanjutnya diartikan hanya sebagai kematangan yang berdasarkan pengalaman, evaluasi, dan pelajaran-pelajaran tertentu. Seperti halnya kini kata kebijaksanaan berkembang menuju ketersesatan. Misalnya seorang pemegang kebijakan disebut telah membijaksanai krooni-kroninya walaupun itu dilakukan dengan cara yang tidak benar. Jadilah pengetahuan hanya stagnan dalam dimensi kepintaran dan semakin jauh dari kebijaksanaan. Jalan keluar dari bencana semacam itu salah satunya dapat dilakukan dengan mencermati teks-teks suci yang masih memelihara integralitas pengetahuan dan kebijaksanaan.
PEMUJAAN TRI MURTI DI PURA DALEM TAAK DESA BATUBULAN KECAMATAN SUKAWATI KABUPATEN GIANYAR
Authors: I Nyoman Alit Supandi
Published: April 2023

Abstrak

Pura Dalam Taak memiliki suatu yang unik yaitu memiliki konsep Tri Murti, karena mengalami suatu integrasi antara Pura Dalem Bantas dan Pura Dalem Taak. Konsep Tri Murti umumnya dipuja di pura tertentu saja, akan tetapi di Pura Dalem Taak Dewa Brahma, Wisnu, Siwa menjadi satu kesatuan pemujaan yang tidak dapat di pisahkan. Di antara Pura Dalem di sekitaran batubulan bahkan mungkin di luar Desa Batubulan, Pura Dalem seperti di Pura Dalem Taak sangat jarang kita temui, dari sinilah penulis memiliki suatu ketertarikan untuk menulis. Adapun rumusan masalah dalam tulisan ini adalah sebagai berikut: (1) Mengapa di Pura Dalem Taak Desa Batubulan, Kecamatan Sukawati, Kabupaten Gianyar terdapat Pemujaan Tri Murti.

Teori yang di gunakan dalam tulisan ini adalah Teori Fungsional Struktural Jenis tulisan ini adalah penelitian kualitatif. Lokasi penelitian yang di tentukan adalah di Pura Dalem Taak Desa Batubulan, Kecamatan Sukawati, Kabupaten Gianyar. Adapun metode pengumpulan data yang digunakan adalah teknik observasi, teknik wawancara, teknik dokumentasi, dan teknik studi kepustakaan.

            Adapun Hasil tulisan ini adalah (1)  Mengapa di Pura Dalem Taak terdapat pemujaan Tri Murti : a) Historis atau sejarah Pura Dalam Taak di implementasikan dalam sradha bhakti, walaupun banyak dewa yang terdapat di Pura Dalem Taak semuannya itu adalah satu yaitu Tuhan. b) Metalogis, masyarakat memiliki sraddhà dan di implementasikan dengan bhakti, sehingga terdapat penguatan melaksanakan sembah bhakti, dengan membawa sarana pamuspan pada saat piodalan maupun sebelum pelaksanaan piodalan. c) Teologis, dapat di lihat dalam aktivitas masyarakat yang tetap melaksanakan sembah bhakti dan pendekataan kepada Tuhan dengan membawa sesajen maupun canang. d) Sosiologis Pura Dalem Taak mampu menyatukan masyarakat atau keluarga yang tinggal jauh mereka bisa bertemu, bersilahturahmi dan berkumpul terutama saat pujawali atau piodalan di Pura Dalem Taak.

 

Kata Kunci : Pemujaan Tri Murti, Pura Dalem Taak.
Platform Media Pembelajaran Interaktif Mata Pelajaran Agama Hindu di Sekolah Dasar
Authors: I Wayan Eka Biasa  , Wahyuni Ni Nyoman Tri
Published: April 2023

Abstrak

Perubahan pola kehidupan manusia turut mempengaruhi pola pendidikan di sekolah. Dunia pendidikan kini sangat dipengaruhi oleh teknologi.  Kegiatan pembelajaran di sekolah tidak terlepas dari penggunaan teknologi, demikian pula penggunaan media berbasis teknologi. Media pembelajaran merupakan perantara pendidik dalam menjelaskan materi pembelajaran kepada peserta didik. Diperlukan media yang interaktif agar dapat meningkatkan minat belajar peserta didik. Pada mata pelajaran Agama Hindu di sekolah dasar yang cenderung banyak hafalan maka diperlukan pula media pembelajaran yang interaktif. Penelitian ini bertujuan untuk mengetahui platform media pembelajaran yang interaktif untuk mata pelajaran agama Hindu di Sekolah Dasar. Penelitian ini mengkaji mengenai konsep dan teori yang digunakan berdasarkan referensi atau literaur yang tersedia, terutama artikel-artikel yang dipublikasikan dalam berbagai jurnal ilmiah. Penelitian ini merujuk pada studi pustaka yang terkait plaiform media pembelajaran interaktif mata pelajaran agama Hindu di Sekolah Dasar. Platform media pembelajaran yang interaktif yang tepat pada mata pelajaran agama Hindu di Sekolah Dasar adalah Quizizz dan Kahoot.  Kedua media ini dapat meningkatkan minat belajar peserta didik serta meningkatkan pemahaman peserta didik pada materi pembelajaran agama Hindu. Penelitian ini dapat dijadikan referensi bagi guru agama Hindu di Sekolah Dasar khususnya dalam memilih platform media pembelajaran yang interaktif.

Kata Kunci: Platform Media Pembelajaran Interaktif, Mata Pelajaran Agama Hindu, Sekolah Dasar
Microsatellite marker assisted molecular and morpho-physiological genetic diversity assessment in 38 genotypes of sesame (Sesamum indicum L.)
Authors: Emon Reza M. , Sakib Md. N. , Khatun Mst. K. , Malek Md. A. , Haque Md. S. , Alam Md. Amirul
Published: April 2023

Identification of genetic diversity and their relationships among breeding materials is crucial in crop improvement strategies. In this study, 38 sesame genotypes were characterized for their genetic diversity. The results revealed significant variations among various traits such as plant height, maturity, capsule plant-1 and seeds capsule-1. The number of capsule plant-1 showed significant positive correlation with seeds capsule-1. The highest heritability was found for the numbers of capsules plant-1 (98.67%). The 38 genotypes were separated into six distinct clusters. Comparison within the populations of the cluster IV and those of cluster VI had the highest capsules plant-1, seeds capsule-1 with enormous genetic diversity. For molecular characterization, 7 microsatellite markers and 5 SSR primers with polymorphism were finally chosen for genetic diversity analysis. Altogether, 19 alleles were identified among the 38 genotypes, and the average number of alleles per locus was 3.80. The lowest and the highest numbers of alleles were 3 and 5, respectively. The polymorphism information content (PIC) ranged from 0.3201 to 0.5934 and SI-ssr30 showed to be highest at 0.5934. The UPGMA based clustering depicted a significant variation at molecular level among the sesame genotypes, having a coefficient of similarity between 0.29 and 1.00. The present study confirmed that extensive genetic diversity existed among the sesame genotypes and valuable agronomic traits may result in the development of high yielding genotypes.
La emoción en acción: ¿Sentir con el cuerpo o sentir en el cuerpo?
Authors: Madroñal Ignacio Federico
Published: April 2023

A lo largo del último siglo, se ha intentado examinar la naturaleza de los estados mentales desde numerosas perspectivas, aunque ignorando con frecuencia que toda teoría de la mente también debe analizar adecuadamente las emociones. El propósito de este trabajo es explicitar los requisitos que debe cumplir una buena teoría acerca de lo emocional, a partir del examen crítico de tres enfoques distintos: el conductismo, el funcionalismo y el enactivismo. Argumentaré que, entre ellos, solo el último constituye una teoría satisfactoria porque explicita el rol precio que cumple la dimensión corporal en nuestra experiencia emocional.
Nietzsche, Levinas. Cuerpo y narrativa
Authors: Bautista-Roa Milton , Choque-Aliaga Osman
Published: April 2023

El artículo aborda la relación entre Nietzsche y Levinas, en particular se enfrenta a la concepción de cuerpo y narración sostenida por cada autor. En ese sentido se afirma que la aparente distancia que existe entre ambos pensadores puede reducirse a partir de las temáticas que se estudian en este trabajo. A la luz de todo ello, la lectura del cuerpo de Nietzsche y la comprensión de narración de Levinas no habrían sido solo reflexiones filosóficas, sino más bien el pretexto para que ambos pensadores critiquen el pensamiento establecido y propongan, cada uno a su modo, un quehacer filosófico que afecta directamente la existencia humana en cuanto reflexión sobre las formas como se comprende la vida misma.
La facultad de juicio femenina
Authors: Angue Medoux Irma Julienne
Published: April 2023

Las feministas han reconocido la importancia de defender la capacidad de pensar de las mujeres y de pensarse a sí mismas; es necesario ir más allá: sólo logramos devolver el respeto a las dominadas duraderas producidas por el machismo patriarcal en el que aún vivimos, al establecer que su facultad de juzgar radica en el uso del diálogo que comparte con los hombres, además de su diferencia de sexo y que sólo podemos disipar todas las presuntas dudas planteadas por violadores e intelectuales que se han mantenido machistas respecto a su facultad femenina de juzgar mostrando su origen en una segunda naturaleza común del lenguaje así como su eficacia. Apoyaremos nuestro análisis con un caso que fue noticia en los medios televisivos de Francia.
ASSOCIAÇÃO ENTRE SINTOMAS NÃO MOTORES E QUEDAS EM INDIVÍDUOS COM DOENÇA DE PARKINSON: REVISÃO INTEGRATIVA
Authors: Souza Pontes Sarah , Lisboa Santiago Nascimento Isabel , Dantas Ingred , De Oliveira Almeida Lorena , Carolina Cunha Lima Ana , Gomes Neto Mansueto
Published: April 2023

RESUMO

Introdução: Doença de Parkinson (DP) é uma doença neurodegenertiva que acomete os núcleos da base, mais especificamente a dopamina, intimamente relacionada aos mecanismos de recompensa e reforçamento dos comportamentos. Isso explica a quantidade de indivíduos portadores da DP com sintomas não motores, como depressão, ansiedade, impulsividade, dor, insônia, alteração de humor. Parece que existe forte participação dos sintomas não motores na queda. Porém, poucos estudos trazem associação ou não com queda nesses indivíduos. Objetivo: Revisar na literatura a associação entre sinais e sintomas não motores e quedas em indivíduo com DP. Métodos: Trata-se de uma revisão de literatura. Pesquisa realizada nas bases de dados Pubmed, Scielo, Lilacs e Medline entre outubro e novembro de 2021. Foram incluídos estudos de caso controle ou coorte que tivesse o tema: sinais e sintomas não motores de indivíduos com DP associado às quedas, de acordo com a NMS SCALE. Foram excluídos àqueles que não se apresentaram na escala, como também os duplicados nas bases de dados. Resultados: Busca resultou em 33 estudos na primeira fase, mas 4 deles não foram encontrados para leitura na íntegra. Após leitura dos 29 estudos, 17 foram excluídos pelo desfecho e apenas 12 foram selecionados. Total 1467 pacientes estudados. Discussão: Sintomas não motores na DP tornaram-se cada vez mais limitantes da funcionalidade e motricidade nesses indivíduos e forte influenciadores de quedas, uma das maiores causa de morte. Conclusão: Se destaca alta significância de determinados sintomas não motores diretamente relacionado às quedas e no estado funcional dos indivíduos com Parkinson.
Exploring the Role of Grandparenting in Enhancing the Positive Mental Health of Children from External Migrant Worker Families
Authors: Rahmatullah Azam Syukur , Astuti Kamsih , Warsah Idi , Suyatno Suyatno , Jaenullah Jaenullah
Published: April 2023

The rising number of Indonesian migrant workers has led to many children being left in the care of their grandparents, who may lack parenting knowledge and cause confusion, affecting the children's personalities. This research focuses on strengthening the positive mental health of migrant workers’ children by their grandmothers as their caregivers in PuringKebumen District, Central Java, Indonesia, selected based on research criteria. The seven Muslim grandmothers produced parenting products with positive mental health demonstrating healthy character, personality, and behavior. The research belongs to field research with a phenomenological approach, while the data collection methods implemented were observation and interviews. This study had four technical criteria for checking data validity: credibility, dependability, transferability, and confirmability. The data obtained were then analyzed reductively, phenomenologically, and editically during data collection. The method of data analysis was done by reducing data, presenting data, drawing conclusions, and carrying out data verification. The results showed that the seven grandmothers focused on strengthening the positive mental health of their grandchildren because a positive mentality could shape positive character, behavior, temperament, and manners, which is the primary source of human beings. Apart from that, the grandchildren become noble individuals wherever they are, get recognition from others because of the good they have done, and be able to reassure their hearts. The basic principles used in the parenting process to strengthen the positive mental health of their grandchildren included trust, strengthening religion-spiritual, honesty, unconditional love, sincerity, steadfastness, earnestness, consistency, and teaching and developing morals in upbringing.
Myeloid sarcoma cases with varied presentations leading to diagnostic delay: A case series
Authors: Bala Saroj , Kumar Amit , Ravina Mudalsha , Dange Prasad , Kashyap Yashwant
Published: April 2023

Myeloid sarcoma (MS) is an extramedullary tumor, which may be isolated or associated with acute myeloid leukemia (AML). In isolated MS, diagnosis may be challenging. Although it may develop at any site, isolated MS of the spine and parotid region are very rare. We found such rare presentations in our patients, so we wanted to highlight the importance of early suspicion and proper evaluation of such cases. To find out cases of MS, we searched clinical records of our patients of AML/MS, who were treated in the past 1 year in our department at All India Institute of Medical Sciences Raipur. We found 20 such cases of AML/MS who were treated with standard 3 + 7 induction chemotherapy and out of them 3 had isolated or associated MS. We selected these three patients for this case series. In this report, we have described the presentations and treatment of these three cases. One of the patients had isolated MS of the spine, who presented initially with paraparesis. Due to atypical presentation, there was a diagnostic delay, but after treatment, he recovered fully. In another case of isolated parotid swelling, initially suspected to be lymphoma, later diagnosed as MS and also found to have bone marrow involvement with detection of t (8;21) consistent with AML. In another typical presentation, the patient had AML associated with orbital MS. With all these three cases, we want to bring to notice the rare presentations of this entity and which may help clinicians to suspect and diagnose it early and which can improve the overall outcome of such patients.
A case of intravascular large B-cell lymphoma – Our clinical experience
Authors: Kumar Karthik , Hajra Subhajit , Dhingra Gaurav , Nath Uttam Kumar
Published: April 2023

Fever of unknown origin is always a diagnostic challenge in establishing etiology. A gentleman in his 70s presented with complaints of fever and dry cough for 2 months duration. We proceeded with contrast imaging of the thorax and abdomen which revealed mild hepatomegaly. Bone marrow examination with bone marrow culture and 18-fluorodeoxyglucose positron emission tomography/computed tomography (18-FDG PET/CT). Bone marrow aspirate smears were hypercellular with around 50% atypical lymphoid cells with plasmacytoid and bizarre morphology with few multilobed nuclei. Bone marrow biopsy revealed predominantly sinusoidal involvement by neoplastic cells. On immunohistochemistry, tumor cells were positive for CD45, CD79a, CD20, and MUM1 and were negative for CD5, CD10, and BCL6. Ki-67 was around 60% in tumor cells. FDG PET/ CT revealed diffusely increased uptake in the both axial and appendicular skeleton with (SUVmax 5.06) and diffusely increased FDG uptake (SUVmax 3.67) noted in the spleen. As intravascular large B-cell lymphoma is a highly aggressive non-Hodgkin lymphoma with a high risk of central nervous system involvement, we treated it with chemoimmunotherapy (R-CHOP) with intrathecal methotrexate. After a clinical follow of 3 months, the patient developed relapsed with a soft-tissue swelling over the right leg. The patient was treated with two cycles of R-DHAP and had progressive disease and started on Ibrutinib, Lenalidomide, and Rituximab (2 cycles). Post two cycles, the patient had progressive disease and switched to acalabrutinib based therapy. After 1 month of acalabrutinib-lenalidomide-rituximab therapy, the patient had disease progression and succumbed to the disease.
Fatigue, chronic fatigue syndrome and migraine: Intersecting the lines through a cross-sectional study in patients with episodic and chronic migraine
Authors: Kumar Hemant , Dhamija Kamakshi , Duggal Ashish , Khwaja Geeta Anjum , Roshan Sujata
Published: April 2023

Objectives:

Fatigue is a common symptom occurring in a variety of disorders. Chronic fatigue syndrome (CFS) is characterized by debilitating fatigue as the core symptom. The risk of CFS is nearly 1.5 times higher in migraine while headaches have been reported in 59% of cases with CFS. However, details of its occurrence and severity remain largely unexplored. The primary objective of our study was to determine the occurrence and severity of fatigue and CFS in patients with episodic and chronic migraine. The secondary objectives were to define their relationship with other common comorbidities.

Materials and Methods:

60 migraine patients (30 each, episodic [EM] and chronic migraine [CM]) were recruited from Neurology Outpatient Department, GIPMER a tertiary referral center in New Delhi, India. Patients’ headache severity was analyzed using the Headache impact test-6 (HIT-6) score while fatigue and other migraine accompaniments were assessed using Fatigue severity scale (FSS), Chalder fatigue scale, CDC diagnostic criteria for CFS, American College of Rheumatology Diagnostic Criteria for fibromyalgia, Hamilton Depression Scale, the Generalized Anxiety Disorder 7-Item Scale, and Epworth sleepiness Scale (ESS). Comparative analysis was further done among migraine patients with and without fatigue and CFS.

Results:

The mean HIT-6 score was significantly higher in CM versus EM. The CM group had a higher mean FSS score (47.87 vs. 37.3 in EM; P = 0.004), a percentage of patients with severe fatigue (60% vs. 20% in EM; P = 0.004), and a higher percentage of patients with pathological fatigue (83.3% vs. 63.3% in EM; P = 0.04). Around 23.33% of CM patients fulfilled the criteria of CFS. Fatigue correlated positively with severity, frequency, attack duration and chronicity of the migraine episodes, along with depression, anxiety, and excessive daytime sleepiness.

Conclusion:

Fatigue and related comorbid disorders are significantly more common in CM than in EM, expanding the morbidity of the condition and underscores the need to address these accompanying symptoms for devising a holistic treatment plan.
Digitized Finnish Newspapers in Digital Humanities Research Projects: Challenges and Solutions from the Library Perspective
Authors: Rautiainen Juha , Zuev Artem E.
Published: April 2023

Libraries have a direct influence on digital humanities (DH) research projects that utilize digitized newspapers from their collections. However, a library’s level of participation in a project will vary and may range from resource provider to active collaborator. Libraries must manage the different expectations of each project; thus, a variety of services are needed.

The National Library of Finland continuously aims to improve its services and provide researchers with broader access to digitized collections. The library’s DH research team has extensive experience in research projects, and they actively support the work of DH researchers. In this paper, I present an overview of the experiences of the DH research team. I focus on projects that have used digitized historical newspapers and journals, and I outline a range of potential problems and suggest possible solutions.
The Extraterritorial Reach of US Export Control Law
Authors: Voetelink Joop
Published: April 2023

In recent years, the United States (US) has dramatically expanded a set of extraterritorial rules, known as the ‘foreign direct product rules’. The rules subject certain items to the jurisdiction of the Export Administration Regulations that are produced outside the US with the use of specific types of US technology, software, or equipment, but contain no US-origin content and are traded between parties outside the US without ever touching US territory. As such extraterritorial rules may breach other States’ sovereign rights, they are only permissible under international law when there is a genuine nexus between the regulating State and the object of regulation. This article argues that, in principle, the foreign direct product rules do not breach international law as US national security concerns, in principle, can justify the rules under the protective principle. The US should, however, better substantiate its decisions to exert its extraterritorial legislative powers to increase acceptance of the rules among affected states.
A water model with improved thermodynamic properties over a large pressure and temperature range optimized using multistate reweighting and configuration space mapping
Authors: Paliwal Himanshu , Shirts Michael
Published: April 2023

We show how reweighting and configuration mapping algorithms can be used to efficiently optimize molecular models using thermodynamic properties at a large number of state points from molecular simulations. As a proof of concept, we perform a multidimensional, multi-objective parameterization of a rigid water model over a large pressure [1-5000 atm] and temperature [274.15-372.15 K] range to the experimental property surfaces estimated using the IAPWS95 equation of state for water. Over 4000 parameter combinations in six-dimensional parameter space were explored during the minimization. A similar parameterization with standard techniques would have taken more than 2000 CPU years but with the application of the newly developed techniques, the computational time was reduced to eight CPU weeks. Without the added efficiency of the methods presented here, the optimization could not have simultaneously taken into account the large range of temperature and pressure points. The paper also describes how and why incorporating the thermodynamic properties from the first derivatives and the second derivatives of Gibbs energy into the objective function help improve the parameterization process.
Assessing Utilization Boundaries for Pt-based Catalysts in an Operating PEMFC
Authors: Ronovský Michal , Pan Lujin , Klingenhof Malte , Martens Isaac , Chattot Raphael , Fusek Lukáš , Kúš Peter , Mirolo Marta , Dionigi Fabio , Burdett Harriet , Sharman Jonathan , Strasser Peter , Bonastre Alex Martinez , Drnec Jakub
Published: April 2023

Octahedra (oh) PtNiX/C catalysts have attracted attention as cathode catalysts for proton-exchange membrane fuel cells (PEMFCs) due to their exceptional catalytic activities toward the oxygen reduction reaction. Here, we investigate the degradation dynamics of oh-PtNiIr in fuel cell conditions by operando X-ray diffraction (XRD). Two XRD-coupled square-wave accelerated stress tests (0.6 to 0.95) V and (0.7 to 0.95) V (where V is the cell voltage) confirm that, when fixing the upper limit, the dissolution and overall degradation strongly depend on the lower potential limit. By directly observing the extent of metal oxidation during potential cycling, we link the alloy redox dynamics to the stability. The studied catalysts' stability is proportional to both the extent of metal oxidation and, more interestingly, the degree of reduction. Comparing a benchmark Pt catalyst with oh-PtNiIr allows for associating the differences between oxidation and reduction potentials and the optimal usage window for each class of catalysts. This relatively simple method can be employed to find the operation boundaries of the PEMFC to minimize the degradation of a large class of Pt-based catalysts without time-consuming stress tests.
Solvent Mediated Excited State Hydrogen Transfer in 6-Azaindole - S3,4 and 2,6-Diazaindole - S3,4 Clusters (S= H2O, NH3)
Authors: Baweja Simran , Kalal Bhavika , Kumar Mitra Prajoy , Maity surajit
Published: April 2023

Excited state hydrogen (ESHT) and proton (ESPT) transfer pathways in the solvent clusters of 6-azaindole 6AI-S3,4 and 2,6-diazaindole 26DAI-S3,4 (S=H2O, NH3) were computationally explored to understand the fate of photo-excited biomolecules. The ESHT energy barriers in (H2O)3 complexes (39.6-41.3 kJmol-1) were decreased in (H2O)4 complexes (23.1-20.2 kJmol-1). Lengthening the solvent chain reduced the barrier because of the relaxed transition states geometries with reduced angular strains. Replacing the water molecule with ammonia drastically decreased the energy barriers to 21.4-21.3 kJmol-1 in (NH3)3 complexes and 8.1-9.5 kJ mol-1 in (NH3)4 complexes. The transition state was identified as Ha atom attached to the first solvent molecule. The formation of stronger hydrogen bonds in (NH3)3,4 complexes resulted in facile ESHT reaction than that in the (H2O)3,4 complexes. The ESPT energy barriers, in 6AI-S3,4 and 26DAI-S3,4 are found to range between 40-73 kJmol-1. The above values were significantly higher than that of the ESHT processes and hence are considered a minor channel in the process. The energetics of ESHT and ESPT explored in this study would be of great importance to study the photochemistry of N-rich biomolecules in the presence of various protic environments.
Probing the Formation of Cathode-Electrolyte Interface on Lithium Iron Phosphate Cathodes via In Operando Mechanical Measurements
Authors: Bal Batuhan , Ozdogru Bertan , Nguyen Dan Thien , Li Zheng , Murugesan Vijayakumar , Çapraz Ömer Özgür
Published: April 2023

Interfacial instabilities in electrodes control the performance and lifetime of Li-ion batteries. While the formation of solid-electrolyte interface (SEI) on anodes has received much attention, there is still lack of understanding about the formation of cathode-electrolyte interface (CEI) on the cathodes. To fill this gap, we report on dynamic deformations on lithium iron phosphate, LiFePO4 cathodes during charge / discharge by utilizing in-operando digital image correlation, impedance spectroscopy and Cryo X-ray photoelectron spectroscopy. LiFePO4 cathodes were cycled in either LiPF6, LiClO4 or LiTFSI- containing organic liquid electrolytes. Beyond the first cycle, Li-ion intercalation results in a nearly linear correlation between electrochemical strains and the state of (dis)-charge, regardless of the electrolyte chemistry. However, during the first charge in LiPF6 - containing electrolyte, there is a distinct irreversible positive strain evolution at the onset of anodic current rise as well as current decay at around 4.0V. Impedance studies show the increase in surface resistance in the same potential window, suggesting the formation of CEI layers on the cathode. The chemistry of the CEI layer was characterized by X-ray photoelectron spectroscopy. LiF is detected in CEI layer starting as early as 3.4 V and LixPOyFz appeared at voltages higher than 4.0 V during the first charge. Our approach offers new insights into the formation mechanism of CEI layers on the cathode electrodes, which is crucial for the development of robust cathode and electrolyte chemistries for higher performance batteries.
Remote Electrostatic Repulsion Trigged by Excited State Antiaromaticity Relief as Origin of Photoacidity in an Organic Dye
Authors: Cid Gomes Leandro , Pace Domenic , Zubiria-Ulacia Maria , Casanova David , Nguyen Thanh Vinh , Ottosson Henrik
Published: April 2023

Photoacids are molecules which become (more) acidic under photoirradiation, and they find valuable applications in organic synthesis and biological chemistry. We herein report a new photoacid, HDMAPAN-(BF4)2, which functions by a different photoacidity mechanism than existing ones. HDMAPAN-(BF4)2, consisting of one dibenzotropylium and one anilinium moiety connected together by a biaryl C-C bond, shows an exceptionally low computed Delta_pKa(hv) (-12.3), which is within the range of superphotoacids. Surprisingly, despite the electronic S0 to S1 transition being located in the dibenzotropylium unit, the photoexcitation affects the acidity of the proton on the anilinium unit. Our computational investigations using TD-DFT reveal that the photoacid is functioning by a new mechanism, in which the excited state antiaromatic character of the dibenzotropylium unit in the S1 state unleashes a local reorganization of the charge distribution, alleviating the destabilizing antiaromatic character. Upon excitation, the positive charge within the dibenzotropylium system is localized on the carbons closest to the anilinium ring, creating an increased electrostatic repulsion against the acidic proton. Placing spacers between the dibenzotropylium and the anilinium moieties gradually reduced the computed Delta_pKa, supporting the electrostatic repulsion between the two ring systems as the main source to the strong photoacidity in HDMAPAN-(BF4)2. Finally, using DFT calculations with point charges, we show that a fractional positive charge indeed destabilizes the anilinium system when it is in close proximity.
Profiling of Active Compounds of Extract Ethanol, n-Hexane, Ethyl Acetate and Fraction Ethanol of Star Anise (Illicium verum Hook. f.) and Determination of Total Flavonoids, Total Phenolics and Their Potential as Antioxidants
Authors: Syukur Mighfar , Prahasiwi Masitoh Suryaning , Nurkhasanah Nurkhasanah , Yuliani Sapto , Purwaningsih Yuliana , Indriyanti Erwin
Published: April 2023

Profiling of chemical compounds on star anise extract and fractions showed the content and looked for active compounds. The main compounds in alkaloids, flavonoids, saponins, phenolics, and triterpenoid forms were identified based on phytochemical screening. FTIR and GC-MS analysis were used to purify the extract and fractions’ main compounds. After analyzing the main components of extract and fractions, a correlation was made between the total phenolic and flavonoid content. The total phenolic content was determined by adding folincalteau complexing solution converted to gallic acid equivalent (GAE), while the total flavonoid content was determined by AlCl3 complexing solution converted to Quercetin Equivalent (QE). The total phenolic yields for extract ethanol, n-hexane fraction, ethyl acetate fraction, and fraction ethanol were obtained at 106.45, 52.30, 93.46, and 148.97 mgGAE/g, respectively. Then the total flavonoid results were 107.45, 58.94, 148.99, 140.01 mgQE/g. The total content of phenolics and flavonoids illustrated the number of active compounds that have a role as free radical scavengers due to their group. Antioxidant activity was tested with 1,1-diphenyl-2-picrylhydrazyl (DPPH) on extracts and fractions, with the best IC50 results obtained in the ethanol fraction 0.416 mg/mL.
Characterization of Synthesized NiCo2O4 with Trisodium Citrate for Supercapacitor Material: A Preliminary Study
Authors: Manalu Andriono , Manalu Istas Pratomo , Panjaitan Muktar Bahruddin , Simanullang Ady Frenly , Sitorus Parlindungan
Published: April 2023

Supercapacitors can be called electrostatic double-layer capacitors (EDLCs) or pseudo-capacitors based on their energy storage mechanism. Pseudo-capacitors with metal oxide electrodes that transmit electric charge offer great application power but low stability. This study aims to characterize trisodium citrate (TSC) modified NiCo2O4/rGO electrodes as a preliminary study for the NiCo2O4 nanoparticle pseudo-capacitor. The materials were characterized using SEM (Scanning Electron Microscopy), XRD (X-Ray Diffractometer), FT-Raman (Fourier Transform Raman Spectroscopy), and FTIR (Fourier Transform Infrared Spectroscopy). All of these analyses confirmed that NiCo2O4 was manufactured successfully using TSC. At XRD, the angles of 2????, namely 45.04 and 53.34°, matched the plane of the cubic phase nanorod crystals of NiCo2O4 with values of 400 and 511, respectively. In the Raman examination, the presence of rGO, which increased the crystallinity of NiCo2O4 nanoparticles, was confirmed. FTIR analysis indicated that the 1550-1600 cm−1 corresponds to a C=C functional group in an aromatic ring or a C=O ????-???? structure, and the wavenumber of 2300 cm−1 corresponds to the OH group in TSC, an alkanoate derivative. SEM analysis determined that NiCo2O4 nanoparticles with 1 mmol TSC are the ideal material for supercapacitor electrodes, as the structure is the most uniform, soft, and tidy. Further analysis is needed to confirm the stability of the modified material.
Catalytic Activity of LDH-TiO2 and LDH-ZnO in Photodegradation of Procion Red
Authors: Yuliasari Nova , Amri Amri , Mohadi Risfidian , Elfita Elfita , Lesbani Aldes
Published: April 2023

Pristine layered double hydroxides (LDHs) which have been modified into LDHs-metal oxide composite were applied as procion red (PR) photodegradation catalysts. The preparation was performed using a low calcination temperature of 300°C. Optimization variations include pH, catalyst weight and catalysis time. The degradation percentages of Mg/Al LDH, Mg/Al-TiO2 and Mg/Al-ZnO were 51.8%, 72.0% and 89.5%, respectively. The percentage of degradation of Zn/Al LDH, Zn/Al-TiO2 and Zn/Al-ZnO were 44.0%, 61.2% and 58.4%, respectively. The study results showed that all composites produced a greater percentage of PR degradation and better reusability than pristine LDH. Mg/Al LDH-based catalysts tend to catalyze PR better than Zn/Al LDH-based catalysts. PR which is an anionic dye when photodegraded using Mg/Al-ZnO tends to be better than Mg/Al-TiO2 meanwhile Zn/Al-TiO2 and Zn/Al-ZnO have competitive performance.
Extension of Exponential Pareto Distribution with the Order Statistics: Some Properties and Application to Lifetime Dataset
Authors: Adeyemi Adewunmi Olaniran , Adeleke Ismail Adedeji , Akarawak Eno Emmanuella
Published: April 2023

The Exponential Pareto (EP) model has been extended by applied and theoretical statisticians for wider applications and new knowledge using different techniques but the Weibull-X technique has not been considered. This article proposed a new extension of the EP model called the Weibull-Exponential Pareto (WEP) distribution to provide better modeling that fits real-life datasets and to explore the statistical theory of order statistics from the proposed distribution. Statistical properties investigated include the Shannon and Renyi entropies; the moments and moment generating function. Distribution of order statistics and the moment of order statistics were derived including the mean and variance of order statistics. WEP distribution has unimodal, decreasing, and increasing failure rates; and it can be negatively or positively skewed and approximately symmetric with the potential for fitting platykurtic, mesokurtic, and leptokurtic lifetime data. The parameters of the distribution were estimated using the method of maximum likelihood estimation (MLE), which was examined for consistency through a simulation study. The performance of the proposed distribution was investigated by application to flood peaks exceedances and some lifetime datasets from engineering. The results from data analysis using the R-software revealed that the WEP distribution has the potential to provide a superior model that fits the three data sets better than some notable existing distributions and previous extensions of the EP model in the literature. The statistical property of order statistics extended in the study established some important results that characterized some notable lifetime distributions in the literature.
Formulation and Evaluation of Azithromycin Dihydrate Solid Dispersion with Esther of Polyethylene Glycol-6000 and Stearic Acid Using A Co-Grinding Technique
Authors: Mardiyanto Mardiyanto , Untari Budi , Mara Ady , Prasetyo Nauval Hady
Published: April 2023

Azithromycin is a narrow-spectrum bacterial growth inhibitory antibiotic derived from macrolides with low dissolution in water. Several methods have been carried out to increase the dissolution of medicinal substances, one of which is solid dispersion. Solid dispersions are mixtures consisting of one or more active substances in an inert carrier. The purpose of this study was to determine the effect of formatting solid dispersions with PEG 6000 polymer and stearic acid on increasing the dissolution rate of azithromycin. The method of formatting solid dispersions uses the co-grinding method. Solid dispersion of azithromycin was prepared in four formulas with variations in the amount of PEG 6000. Tests carried out on solid dispersion samples of azithromycin were XRD, FTIR, SEM, solubility tests, and dissolution tests. Test results on azithromycin solid dispersions prepared by co-grinding showed that there was an effect of the amount of PEG 6000 on decreasing the intensity of azithromycin crystals, there was no chemical interaction between azithromycin and the carrier, differences in the morphology of pure azithromycin powder and solid dispersions, and an increase in the dissolution of solid dispersions in medium SIF.
A review to access knowledge, attitudes, and practices among nurses of cardiac medicine for heart failure patients to prevent readmission in hospitals
Authors: Anny Ashiq Ali , Somia Sagheer
Published: April 2023

This research paper conducts an in-depth evaluation in order to improve nurses' comprehension of self-care management and patient discharge education for patients with Heart Failure (HF). It also discusses the reasons and obstacles to nurses for increasing their knowledge, attitude, and practice to support improved health outcomes and reduce readmission. In order to prevent readmission and re-hospitalization through discharge training, this study aims to raise awareness about the gaps in knowledge, practice, and attitude among nurses working with patients admitted with heart failure. The study evaluates the nurses' knowledge and aids in the education that heart failure patients must receive. By using effective medication management and post-discharge instructions, heart failure symptoms and disease progression can be controlled. Therefore, effective medication management following discharge is crucial for improving the quality of life, controlling symptoms, avoiding deterioration that triggers hospital readmission, and reducing death. Additionally, it is not always possible for healthcare team members to exchange enough accurate information with one another effectively. Numerous nations have emphasised the importance of the right health practices, optimistic attitudes, and suitable education among healthcare professionals to dispel misconceptions, increase confidence in providing support, and promote effective treatment.