bluuebunny/crossref_metadata_2025 huggingface dataset:
Subchorionic Hematoma Association with Pregnancy Complications and Outcomes in the Third Trimester
Authors: Huang Haixia , Han Huan , Xie Han , Ying Hao , Bao Yirong
Published: March 2023

Introduction: Our objective was to explore the clinical features, pregnancy complications, and outcomes of subchorionic hematomas (SCHs) in the third trimester. Material and methods: This was a retrospective analysis and evaluation of 1112 cases diagnosed with SCHs from January 2014 to December 2020. Comparisons were performed according to the clinical features (e.g., number of pregnancies, parity, gestational weeks, and age), pregnancy complications, and outcomes associated with SCHs. Results: In total, 71.85% (799/1112) of the patients were diagnosed with different pregnancy complications. The overall rates of gestational diabetes mellitus (GDM), hypertensive disorder complicating pregnancy (HDCP), premature rupture of membranes (PROM), and IVF were 12.14%, 7.55%, 17.27%, and 10.34%, respectively. The positive rates for newborn outcomes such as premature birth and low birth weight (LBW) were 9.35% and 6.47%, respectively. There was a significant relationship between repeated pregnancies and the incidence of GDM (p < 0.05), but not HDCP, PROM, or IVF. The proportion of SCH patients who conceived through IVF was significantly higher among primiparas than among multiparas (p < 0.05), but was not significantly different in terms of GDM, HDCP, or PROM. Premature birth was not a high-risk factor for most SCH patients with HDCP, IVF, or PROM (p < 0.05), most of whom delivered at term. The rate of cesarean sections for SCH patients with GDM, HDCP, or IVF was significantly higher than that for vaginal deliveries (p < 0.05), but this was not affected by age. Conclusions: The coexistence of SCHs with HDCP, IVF, or PROM lacked an effective predictive value for premature birth, but increased the rate of a cesarean section.
Urban Flood Hazard Assessment and Management Practices in South Asia: A Review
Authors: Manandhar Bikram , Cui Shenghui , Wang Lihong , Shrestha Sabita
Published: March 2023

Urban flooding is a frequent disaster in cities. With the increasing imperviousness caused by rapid urbanization and the rising frequency and severity of extreme events caused by climate change, the hydrological status of the urban area has changed, resulting in urban floods. This study aims to identify trends and gaps and highlight potential research prospects in the field of urban flooding in South Asia. Based on an extensive literature review, this paper reviewed urban flood hazard assessment methods using hydraulic/hydrological models and urban flood management practices in South Asia. With the advancement of technology and high-resolution topographic data, hydrologic/hydraulic models such as HEC-RAS/HMS, MIKE, SWMM, etc., are increasingly used for urban flood hazard assessment. Urban flood management practices vary among countries based on existing technologies and infrastructures. In order to control urban flooding, both conventional physical structures, including drainage and embankments, as well as new innovative techniques, such as low-impact development, are implemented. Non-structural flood mitigation measures, such as improved flood warning systems, have been developed and implemented in a few cities. The major challenge in using process-based hydraulic models was the lack of high-resolution DEM and short-duration rainfall data in the region, significantly affecting the model’s simulation results and the implementation of flood management measures. Risk-informed management must be implemented immediately to reduce the adverse effects of climate change and unplanned urbanization on urban flooding. Therefore, it is crucial to encourage emergency managers and local planning authorities to consider a nature-based solution in an integrated urban planning approach to enhances urban flood resilience.
Cathedral of Sts. Vitus, Wenceslas, and Adalbert—The Melting Pot of Czech Religious, National, and State Identity and Its Legal Status
Authors: Frinta Ondřej , Frintová Dita
Published: March 2023

The article first focuses on the significance of the Cathedral of Sts. Vitus, Wenceslas, and Adalbert to the Czech religious, national, and state identity. The importance of the cathedral is given primarily by its location (Prague Castle), as well as by the thinking of its founder, Charles IV, about the foundations of Czech statehood. On the basis of these findings, the significance and symbolism of the cathedral for the present can be understood. Following this, the legal status of the cathedral, which was the subject of the so-called “cathedral dispute” in its modern history, is examined. The current legal status of the cathedral is the result of an amicable solution to this dispute and the subsequent application of the right of superficies in Czech private law.
Malnutrition Patterns in Children with Chronic Kidney Disease
Authors: Karava Vasiliki , Dotis John , Kondou Antonia , Printza Nikoleta
Published: March 2023

Malnutrition is frequent in children with chronic kidney disease (CKD). Apart from undernutrition and protein energy wasting (PEW), overnutrition prevalence is rising, resulting in fat mass accumulation. Sedentary behavior and unbalanced diet are the most important causal factors. Both underweight and obesity are linked to adverse outcomes regarding renal function, cardiometabolic risk and mortality rate. Muscle wasting is the cornerstone finding of PEW, preceding fat loss and may lead to fatigue, musculoskeletal decline and frailty. In addition, clinical data emphasize the growing occurrence of muscle mass and strength deficits in patients with fat mass accumulation, attributed to CKD-related wasting processes, reduced physical activity and possibly to obesity-induced inflammatory diseases, leading to sarcopenic obesity. Moreover, children with CKD are susceptible to abdominal obesity, resulting from high body fat distribution into the visceral abdomen compartment. Both sarcopenic and abdominal obesity are associated with increased cardiometabolic risk. This review analyzes the pathogenetic mechanisms, current trends and outcomes of malnutrition patterns in pediatric CKD. Moreover, it underlines the importance of body composition assessment for the nutritional evaluation and summarizes the advantages and limitations of the currently available techniques. Furthermore, it highlights the benefits of growth hormone therapy and physical activity on malnutrition management.
Demystifying the Value of Minimal Clinically Important Difference in the Cardiothoracic Surgery Context
Authors: Magouliotis Dimitrios E. , Bareka Metaxia , Rad Arian Arjomandi , Christodoulidis Grigorios , Athanasiou Thanos
Published: March 2023

The aim of this review is to describe the different statistical methods used in estimating the minimal clinically important difference (MCID) for the assessment of quality of life (QOL)-related and clinical improvement interventions, along with their implementation in cardiothoracic surgery. A thorough literature search was performed in three databases (PubMed/Medline, Scopus, Google Scholar) for relevant articles from 1980 to 2022. We included articles that implemented and assessed statistical methods used to estimate the concept of MCID in cardiothoracic surgery. MCID has been successfully implemented in several medical specialties. Anchor-based and distribution-based methods are the most common approaches when evaluating the MCID. Nonetheless, we found only five studies investigating the MCID in the context of cardiothoracic surgery. Four of them used anchor-based approaches, and one used both anchor-based and distribution-based methods. MCID values were very variable depending on the methods applied, as was the clinical context of the study. The variables of interest were certain QOL measuring questionnaires, used as anchors. Multiple anchors and methods were applied, leading to different estimations of MCID. Since cardiothoracic surgery is related to important perioperative morbidity, MCID might represent an important and efficient adjunct tool to interpret clinical outcomes. The need for MCID methodology implementation is even higher in patients with heart failure undergoing cardiac surgery. More studies are needed to validate different MCID methods in this context.
Obesity and Wound Healing: Focus on Mesenchymal Stem Cells
Authors: Alma Antonio , Marconi Guya Diletta , Rossi Elena , Magnoni Cristina , Paganelli Alessia
Published: March 2023

Chronic wounds represent nowadays a major challenge for both clinicians and researchers in the regenerative setting. Obesity represents one of the major comorbidities in patients affected by chronic ulcers and therefore diverse studies aimed at assessing possible links between these two morbid conditions are currently ongoing. In particular, adipose tissue has recently been described as having metabolic and endocrine functions rather than serving as a mere fat storage deposit. In this setting, adipose-derived stem cells, a peculiar subset of mesenchymal stromal/stem cells (MSCs) located in adipose tissue, have been demonstrated to possess regenerative and immunological functions with a key role in regulating both adipocyte function and skin regeneration. The aim of the present review is to give an overview of the most recent findings on wound healing, with a special focus on adipose tissue biology and obesity.
Characterization of Human, Ovine and Porcine Mesenchymal Stem Cells from Bone Marrow: Critical In Vitro Comparison with Regard to Humans
Authors: Westerkowsky Elisa Katja , Soares de Almeida Adriana Marisa , Selle Michael , Harms Oliver , Bundkirchen Katrin , Neunaber Claudia , Noack Sandra
Published: March 2023

For research and clinical use of stem cells, a suitable animal model is necessary. Hence, the aim of this study was to compare human-bone-marrow-derived mesenchymal stem cells (hBMSCs) with those from sheep (oBMSCs) and pigs (pBMSCs). The cells from these three species were examined for their self-renewal potential; proliferation potential; adhesion and migration capacity; adipogenic, osteogenic and chondrogenic differentiation potential; and cell morphology. There was no significant difference between hBMSCs and pBMSCs in terms of self-renewal potential or growth potential. The oBMSCs exhibited a significantly higher doubling time than hBMSCs from passage 7. The migration assay showed significant differences between hBMSCs and pBMSCs and oBMSCs—up to 30 min, hBMSCs were faster than both types and after 60 min faster than pBMSCs. In the adhesion assay, hBMSCs were significantly better than oBMSCs and pBMSCs. When differentiating in the direction of osteogenesis, oBMSCs and pBMSCs have shown a clearer osteogenic potential. In all three species, adipogenesis could only be evaluated qualitatively. The chondrogenic differentiation was successful in hBMSCs and pBMSCs in contrast to oBMSCs. It is also important to note that the cell size of pBMSCs was significantly smaller compared to hBMSCs. Finally, it can be concluded that further comparative studies are needed to draw a clear comparison between hBMSCs and pBMSCs/oBMSCs.
Wear Development in Oscillating Rolling Element Bearings
Authors: Wandel Sebastian , Bartschat Arne , Glodowski Jakob , Bader Norbert , Poll Gerhard
Published: March 2023

Rotor blade bearings enable rotor blades to pivot about their longitudinal axis and thus control the power output and reduce the loads acting on the wind turbine. Over a design period of 20 years, rolling bearings are exposed to frequent oscillation movements with amplitude ratios of x/2b > 1, especially due to new control concepts such as Individual Pitch Control, which can lead to wear and a reduction in service life. The objective of this paper was to identify the dominant wear mechanisms and their consequences for the operation of oscillating bearings. Oscillating experiments with an increasing number of cycles on the angular contact ball bearings of two different sizes (types 7208 and 7220) show that the damage initiation starts with adhesive and corrosive wear mechanisms, which result in a sharp increase in the torque as well as the wear volume on the bearing raceway. As the number of cycles increases, an abrasive mechanism occurs, resulting in a lower slope of the wear curve and a smoothing of the resulting wear depressions. The wear and torque curves were evaluated and classified using an energy-wear approach according to Fouvry.
The Ionization of Polymeric Materials Accelerates Protein Deposition on Hydrogel Contact Lens Material
Authors: Ahn Jihye , Choi Moonsung
Published: March 2023

Contact lens materials include polymers that are ionized in the ocular pH condition and are susceptible to protein deposition due to their surface characteristics. Herein, we investigated the effect of the electrostatic state of the contact lens material and protein on protein deposition level using hen egg white lysozyme (HEWL) and bovine serum albumin (BSA) as model proteins and etafilcon A and hilafilcon B as model contact lens materials. Only HEWL deposition on etafilcon A showed a statistically significant pH-dependency (p < 0.05); protein deposition increased with pH. HEWL showed a positive zeta potential at acidic pH, while BSA showed a negative zeta potential at basic pH. Only etafilcon A showed a statistically significant pH-dependent point of zero charge (PZC) (p < 0.05), implying that its surface charge became more negative under basic conditions. This pH-dependency of etafilcon A is attributed to the pH-responsive degree of ionization of its constituent methacrylic acid (MAA). The presence of MAA and its degree of ionization could accelerate protein deposition; more HEWL deposited as pH increased despite the weak positive surface charge of HEWL. The highly negatively charged etafilcon A surface attracted HEWL, even overwhelming weak positive charge of HEWL, increasing the deposition with pH.
Mechanics and Analysis of Advanced Materials and Structures
Authors: Yoshida Sanichiro , Pappalettera Giovanni
Published: March 2023

Modern technological development has made the designing and characterization of materials sophisticated [...]
Influence of Stretching on Liquid Transport in Knitted Fabrics
Authors: Matusiak Małgorzata , Sukhbat Otgonsuren
Published: March 2023

The transport of liquid sweat in clothing worn close to human skin is very important from the point of view of the thermo-physiological comfort of clothing users. It ensures the drainage of sweat secreted by the human body and condensed on the human skin. In the presented work, knitted fabrics made of cotton and cotton blends with other fibers (elastane, viscose, polyester) were measured in the range of liquid moisture transport using the Moisture Management Tester MMT M290. The fabrics were measured in unstretched form and stretched to 15%. Stretching of the fabrics was performed using the MMT Stretch Fabric Fixture. Obtained results confirmed that stretching significantly changed the values of parameters characterizing the liquid moisture transport in the fabrics. Before stretching, the best liquid sweat transport performance was stated for the KF5 knitted fabric made of 54% cotton and 46% polyester. For this, the greatest value (10 mm) of maximum wetted radius for the bottom surface was obtained. The Overall Moisture Management Capacity (OMMC) of the KF5 fabric was 0.76. This was the highest value among all values obtained for the unstretched fabrics. The lowest value of the OMMC parameter (0.18) was stated for the KF3 knitted fabric. After stretching, the KF4 fabric variant was assessed as the best one. Its OMMC improved from 0.71 before stretching to 0.80 after stretching. The value of the OMMC for the KF5 fabric remained after stretching at the same level (0.77) than before stretching. The most significant improvement was observed for the KF2 fabric. Before stretching, the value of the OMMC parameter for the KF2 fabric was 0.27. After stretching, the OMMC value increased to 0.72. It was also stated that the changes in the liquid moisture transport performance of the investigated knitted fabrics were different for the particular fabrics being investigated. Generally, in all cases, the ability of the investigated knitted fabrics to transfer liquid sweat was improved after stretching.
Acoustic Performance of Floors Made of Composite Panels
Authors: Nurzyński Jacek , Nowotny Łukasz
Published: March 2023

Airborne and impact sound insulation of composite panels arranged in different configurations were investigated in this study. The use of Fiber Reinforced Polymers (FRPs) in the building industry is growing; however, poor acoustic performance is a critical issue for their general employment in residential buildings. The study aimed to investigate possible methods of improvement. The principal research question involved the development of a composite floor satisfying acoustic expectations in dwellings. The study was based on the results of laboratory measurements. The airborne sound insulation of single panels was too low to meet any requirements. The double structure improved the sound insulation radically at middle and high frequencies but the single number values were still not satisfactory. Finally, the panel equipped with the suspended ceiling and floating screed achieved adequate level of performance. Regarding impact sound insulation, the lightweight floor coverings were ineffective and they even enhanced sound transmission in the middle frequency range. Heavy floating screeds behaved much better but the improvement was too small to satisfy acoustic requirements in residential buildings. The composite floor with a dry floating screed and a suspended ceiling appeared satisfactory with respect to airborne and impact sound insulation; the single number values were Rw (C; Ctr) = 61 (−2; −7) dB, and Ln,w = 49 dB, respectively. The results and conclusions outline directions for further development of an effective floor structure.
Acoustic Performance of Stress Gradient-Induced Deflection of Triangular Unimorphic/Bimorphic Cantilevers for MEMS Applications
Authors: Yuan Ning-Hsiu , Chen Chih-Chia , Fuh Yiin-Kuen , Li Tomi T.
Published: March 2023

This paper reports two piezoelectric materials of lead zirconium titanate (PZT) and aluminum nitride (AlN) used to simulate microelectromechanical system (MEMS) speakers, which inevitably suffered deflections as induced via the stress gradient during the fabrication processes. The main issue is the vibrated deflection from the diaphragm that influences the sound pressure level (SPL) of MEMS speakers. To comprehend the correlation between the geometry of the diaphragm and vibration deflection in cantilevers with the same condition of activated voltage and frequency, we compared four types of geometries of cantilevers including square, hexagon, octagon, and decagon in triangular membranes with unimorphic and bimorphic composition by utilizing finite element method (FEM) for physical and structural analyses. The size of different geometric speakers did not exceed 10.39 mm2; the simulation results reveal that under the same condition of activated voltage, the associated acoustic performance, such as SPL for AlN, is in good comparison with the simulation results of the published literature. These FEM simulation results of different types of cantilever geometries provide a methodology design toward practical applications of piezoelectric MEMS speakers in the acoustic performance of stress gradient-induced deflection in triangular bimorphic membranes.
Effect of Hydrothermal Factors on the Microhardness of Bulk-Fill and Nanohybrid Composites
Authors: Pieniak Daniel , Niewczas Agata M. , Pikuła Konrad , Gil Leszek , Krzyzak Aneta , Przystupa Krzysztof , Kordos Paweł , Kochan Orest
Published: March 2023

This study evaluates the effect of aging in artificial saliva and thermal shocks on the microhardness of the bulk-fill composite compared to the nanohybrid composite. Two commercial composites, Filtek Z550 (3M ESPE) (Z550) and Filtek Bulk-Fill (3M ESPE) (B-F), were tested. The samples were exposed to artificial saliva (AS) for one month (control group). Then, 50% of the samples from each composite were subjected to thermal cycling (temperature range: 5–55 °C, cycle time: 30 s, number of cycles: 10,000) and another 50% were put back into the laboratory incubator for another 25 months of aging in artificial saliva. The samples’ microhardness was measured using the Knoop method after each stage of conditioning (after 1 month, after 10,000 thermocycles, after another 25 months of aging). The two composites in the control group differed considerably in hardness (HK = 89 for Z550, HK = 61 for B-F). After thermocycling, the microhardness decrease was for Z550 approximately 22–24% and for B-F approximately 12–15%. Hardness after 26 months of aging decreased for Z550 (approximately 3–5%) and B-F (15–17%). B-F had a significantly lower initial hardness than Z550, but it showed an approximately 10% lower relative reduction in hardness.
First-Order Reversal Curves of Sets of Bistable Magnetostrictive Microwires
Authors: Cabanas Ana María , Pérez del Real Rafael , Laroze David , Vázquez Manuel
Published: March 2023

Amorphous microwires have attracted substantial attention in the past decade because of their useful technological applications. Their bistable magnetic response is determined by positive or negative magnetostriction, respectively. First-order reversal curves (FORC) are a powerful tool for analyzing the magnetization reversal processes of many-body ferromagnetic systems that are essential for a deeper understanding of those applications. After theoretical considerations about magnetostatic interactions among microwires, this work introduces a systematic experimental study and analysis of the FORC diagrams for magnetostrictive microwires exhibiting an individually bistable hysteresis loop, from a single microwire to sets of an increasing number of coupled microwires, the latter considered as an intermediate case to the standard many-body problem. We performed the study for sets of quasi-identical and different hysteretic microwires where we obtained the coercivity Hc and interaction Hu fields. In the cases with relevant magnetostatic interactions, FORC analysis supplies deeper information than standard hysteresis loops since the intrinsic fluctuations of the switching field generate a complex response. For sets of microwires with very different coercivity, the coercivity distributions of the individual microwires characterize the FORC diagram.
Experimental Study and Modelling of Fresh Behaviours of Basalt Fibre-Reinforced Mortar Based on Average Water Film Thickness and Fibre Factor
Authors: Li Leo Gu , Ng Pui-Lam , Zeng Kai-Long , Xie Hui-Zhu , Cheng Cong-Mi , Kwan Albert Kwok-Hung
Published: March 2023

Though previous studies have indicated that the fresh behaviours of plain mortar/concrete are mainly governed by the average water film thickness (AWFT), whether the concept of AWFT is also applicable to fibrous mortar/concrete still needs to be explored. Furthermore, for fibrous mortar/concrete, it is obvious that the fibres added also have certain effects on the fresh behaviours. In two previous studies on basalt fibre-reinforced mortar (BFRM), the integral effects of the AWFT and fibre dosage as well as the integral effects of the AWFT and fibre length were individually investigated. In this study, a fibre factor (FF) defined as the fibre volume multiplied by the fibre aspect ratio was employed and 24 extra mortar groups were tested. A total of 68 mortar groups were applied in numerical analysis. The results of the regression analysis yielded good correlations of the workability, fluidity, cohesiveness, and adhesiveness of BFRM with the AWFT and FF, suggesting that the AWFT and FF are together the governing parameters controlling the fresh behaviours of BFRM. Hence, the AWFT and FF may be used to develop a model for the fresh properties of BFRM.
Production of Nano Hydroxyapatite and Mg-Whitlockite from Biowaste-Derived products via Continuous Flow Hydrothermal Synthesis: A Step towards Circular Economy
Authors: Nigar Farah , Johnston Amy-Louise , Smith Jacob , Oakley William , Islam Md Towhidul , Felfel Reda , Grant David , Lester Edward , Ahmed Ifty
Published: March 2023

Biowastes from agriculture, sewage, household wastes, and industries comprise promising resources to produce biomaterials while reducing adverse environmental effects. This study focused on utilising waste-derived materials (i.e., eggshells as a calcium source, struvite as a phosphate source, and CH3COOH as dissolution media) to produce value-added products (i.e., calcium phosphates (CaPs) derived from biomaterials) using a continuous flow hydrothermal synthesis route. The prepared materials were characterised via XRD, FEG-SEM, EDX, FTIR, and TEM analysis. Magnesium whitlockite (Mg-WH) and hydroxyapatite (HA) were produced by single-phase or biphasic CaPs by reacting struvite with either calcium nitrate tetrahydrate or an eggshell solution at 200 °C and 350 °C. Rhombohedral-shaped Mg-WH (23–720 nm) along with tube (50–290 nm diameter, 20–71 nm thickness) and/or ellipsoidal morphologies of HA (273–522 nm width) were observed at 350 °C using HNO3 or CH3COOH to prepare the eggshell and struvite solutions, and NH4OH was used as the pH buffer. The Ca/P (atomic%) ratios obtained ranged between 1.3 and 1.7, indicating the formation of Mg-WH and HA. This study showed that eggshells and struvite usage, along with CH3COOH, are promising resources as potential sustainable precursors and dissolution media, respectively, to produce CaPs with varying morphologies.
Mountaineering Team-Based Optimization: A Novel Human-Based Metaheuristic Algorithm
Authors: Faridmehr Iman , Nehdi Moncef L. , Davoudkhani Iraj Faraji , Poolad Alireza
Published: March 2023

This paper proposes a novel optimization method for solving real-world optimization problems. It is inspired by a cooperative human phenomenon named the mountaineering team-based optimization (MTBO) algorithm. Proposed for the first time, the MTBO algorithm is mathematically modeled to achieve a robust optimization algorithm based on the social behavior and human cooperation needed in considering the natural phenomena to reach a mountaintop, which represents the optimal global solution. To solve optimization problems, the proposed MTBO algorithm captures the phases of the regular and guided movement of climbers based on the leader’s experience, obstacles against reaching the peak and getting stuck in local optimality, and the coordination and social cooperation of the group to save members from natural hazards. The performance of the MTBO algorithm was tested with 30 known CEC 2014 test functions, as well as on classical engineering design problems, and the results were compared with that of well-known methods. It is shown that the MTBO algorithm is very competitive in comparison with state-of-art metaheuristic methods. The superiority of the proposed MTBO algorithm is further confirmed by statistical validation, as well as the Wilcoxon signed-rank test with advanced optimization algorithms. Compared to the other algorithms, the MTBO algorithm is more robust, easier to implement, exhibits effective optimization performance for a wide range of real-world test functions, and attains faster convergence to optimal global solutions.
Optimization Model and Algorithm of Logistics Vehicle Routing Problem under Major Emergency
Authors: Tan Kangye , Liu Weihua , Xu Fang , Li Chunsheng
Published: March 2023

The novel coronavirus pandemic is a major global public health emergency, and has presented new challenges and requirements for the timely response and operational stability of emergency logistics that were required to address the major public health events outbreak in China. Based on the problems of insufficient timeliness and high total system cost of emergency logistics distribution in major epidemic situations, this paper takes the minimum vehicle distribution travel cost, time cost, early/late punishment cost, and fixed cost of the vehicle as the target, the soft time window for receiving goods at each demand point, the rated load of the vehicle, the volume, maximum travel of the vehicle in a single delivery as constraints, and an emergency logistics vehicle routing problem optimization model for major epidemics was constructed. The convergence speed improvement strategy, particle search improvement strategy, and elite retention improvement strategy were introduced to improve the particle swarm optimization (PSO) algorithm for it to be suitable for solving global optimization problems. The simulation results prove that the improved PSO algorithm required to solve the emergency medical supplies logistics vehicle routing problem for the major emergency can reach optimal results. Compared with the basic PSO algorithm, the total cost was reduced by 20.09%.
Application of Optimized ORB Algorithm in Design AR Augmented Reality Technology Based on Visualization
Authors: Yan Hai’an , Wang Jian , Zhang Peng
Published: March 2023

The current media digitization and artistic strength are more powerful than the previous application. Using its advanced information display methods and technologies, this paper proposed a digital museum built by integrating digital media art with AR technology, which was helpful to analyze and solve the objective problems of current museums’ ecological imbalance and single-system function. Based on the principles and laws of augmented reality technology, the museum guide system is optimized. In the system evaluation experiment, firstly, the cultural relics of six kinds of materials are used as the target image to extract and identify the features of the image. In experiments, the recognition performance of three feature algorithms, Binary Robust Invariant Scalable Keypoints (BRISK), organizational retaliatory behavior (ORB), and Accelerated-KAZE (AKAZE), is compared. Among them, the ORB algorithm is superior to other algorithms in feature richness and recognition speed but is inferior to the other two algorithms in recognition accuracy. Therefore, this paper optimized the ORB algorithm based on the characteristics of the ORB algorithm. The ORB algorithm must calculate the orientation of the feature points before constructing the feature descriptor. After optimizing the parameters, the improved ORB algorithm not only has advantages in feature richness and recognition time but also improves the recognition accuracy up to 98.3%, which is 16% higher than the traditional ORB algorithm. Therefore, the application prospects of AR technology in digital media design are very important.
Modified Signaling of Membrane Formyl Peptide Receptors in NADPH-Oxidase Regulation in Obesity-Resistant Mice
Authors: Tikhonova Irina , Dyukina Alsu , Shaykhutdinova Elvira , Safronova Valentina
Published: March 2023

The signaling of membrane receptors is modified in obesity characterized by low-grade inflammation. The obesity-resistant state of organisms is poorly understood. We analyzed the generation of reactive oxygen species (ROS) initiated though membrane formyl peptide receptors (Fpr1, Fpr2) in bone-marrow granulocytes of obesity-resistant mice (ORM). A chemiluminescence assay was used to assess NADPH-oxidase-related intensity of ROS generation. ORM were chosen from animals that received high-fat diets and had metric body parameters as controls (standard diet). High spontaneous ROS production was observed in ORM cells. The EC50 for responses to bacterial or mitochondrial peptide N-formyl-MLF was higher in ORM with and without inflammation vs. the same control groups, indicating an insignificant role of high-affinity Fpr1. Increased responses to synthetic peptide WKYMVM (Fpr2 agonist) were observed in controls with acute inflammation, but they were similar in other groups. Fpr2 was possibly partially inactivated in ORM owing to the inflammatory state. Weakened Fpr1 and Fpr2 signaling via MAPKs was revealed in ORM using specific inhibitors for p38, ERK1/2, and JNK. P38 signaling via Fpr2 was lower in ORM with inflammation. Thus, a high-fat diet modified FPRs’ role and suppressed MAPK signaling in NADPH-oxidase regulation in ORM. This result can be useful to understand the immunological features of obesity resistance.
Conformal and Transparent Al2O3 Passivation Coating via Atomic Layer Deposition for High Aspect Ratio Ag Network Electrodes
Authors: Lee Ju-Hyeon , Choi Tae-Yang , Cheon Ho-Sung , Youn Hye-Young , Lee Gun-Woo , Lee Sung-Nam , Kim Han-Ki
Published: March 2023

We demonstrated conformal Al2O3 passivation via atomic layer deposition (ALD) of a flexible Ag network electrode possessing a high aspect ratio. The Ag network electrode passivated by the ALD-grown Al2O3 film demonstrated constant optical transmittance and mechanical flexibility relative to the bare Ag network electrode. Owing to the conformal deposition of the Al2O3 layer on the high aspect ratio Ag network electrode, the electrode exhibited more favorable stability than its bare Ag-network counterpart. To demonstrate the feasibility of Al2O3 passivation via ALD on a flexible Ag network, the performances of flexible and transparent thin-film heaters (TFHs) with both a bare Ag network and that passivated by ALD-grown Al2O3 were compared. The performance of Al2O3/Ag network-based TFHs was minimally altered even after harsh environmental tests at 85% relative humidity and a temperature of 85 °C, while the performance of bare electrode-based TFHs significantly deteriorated. The improved stability and reliability of the Al2O3/Ag network-based TFHs indicate that the ALD-grown Al2O3 film effectively prevents the introduction of moisture and impurities into the Ag network with a high aspect ratio. The improvement in the stability of the Ag network through Al2O3 passivation implies that the ALD-grown Al2O3 film represents a promising transparent and flexible thin film passivation material for high quality Ag network electrodes with high aspect ratios.
Experimental Study on Anchoring Performance of Short-Lapped-Rebar Splices with Pre-Set Holes and Spiral Hoops
Authors: Liu Quanwei , Liu Xi , Chen Ran , Kong Zhengyi , Xiang Tengfei
Published: March 2023

The precast concrete structure has the advantage of a short construction period, less labor consumption, and less pollution. The lapped-rebar splice is a type of connection for assembled reinforced concrete shear walls in the precast concrete structure. In this study, the anchoring performance of a short-lapped-rebar splice with a corrugated metal duct and spiral hoops is investigated. A total of 30 specimens were designed considering the influences of the rebar diameter and the lapped length, and the tension testing of the splice was carried out. The results show that the specimens with 0.15 times the suggested length in GB 50010-2010 fail by the fracture of rebar, while the specimens with 0.1 times and 0.05 times the suggested length show the pull-out failure of rebar. The ultimate bond strength of specimens with the suggested length is higher than that of the conventional specimens. The stress of the anchored rebar in the short-lapped-rebar splices is distributed symmetrically along the longitudinal direction. The maximum bond stress of the anchored rebar reaches 35 MPa, which is approximately 1.4 times that in the conventional specimens. A semi-empirical model for predicting the ultimate bond strength of the short-lapped-rebar splice is proposed, and it shows good agreement with tested values; the average error estimated from the proposed model is only 4.49%.
Natural Corynanthe-Type Cholinesterase Inhibitors from Malaysian Uncaria attenuata Korth.: Isolation, Characterization, In Vitro and In Silico Studies
Authors: Chear Nelson Jeng-Yeou , Ching-Ga Tan Ai Fein , Khaw Kooi-Yeong , León Francisco , Tan Wen-Nee , Yusof Siti R. , McCurdy Christopher R. , Murugaiyah Vikneswaran , Ramanathan Surash
Published: March 2023

The Uncaria genus is notable for its therapeutic potential in treating age-related dementia, such as Alzheimer’s disease. A phytochemical study of the leaves of Malaysian Uncaria attenuata Korth., afforded an undescribed natural corynanthe-type oxindole alkaloid, isovillocarine D (1) together with two known indole alkaloids, villocarine A (2) and geissoschizine methyl ether (3), and their structural identification was performed with extensive mono- and bidimensional NMR and MS spectroscopic methods. The isolated alkaloids were evaluated for their acetylcholinesterase (AChE)- and butyrylcholinesterase (BChE)-inhibitory activity. The results indicated that compound (2) was the most potent inhibitor against both AChE and BChE, with IC50 values of 14.45 and 13.95 µM, respectively, whereas compounds (1) and (3) were selective BChE inhibitors with IC50 values of 35.28 and 17.65 µM, respectively. In addition, molecular docking studies revealed that compound (2) interacts with the five main regions of AChE via both hydrogen and hydrophobic bonding. In contrast to AChE, the interactions of (2) with the enzymatic site of BChE are established only through hydrophobic bonding. The current finding suggests that U. attenuata could be a good source of bioactive alkaloids for treating age-related dementia.
Formulation and Evaluation of Xanthan Gum Microspheres for the Sustained Release of Metformin Hydrochloride
Authors: Yahoum Madiha Melha , Toumi Selma , Tahraoui Hichem , Lefnaoui Sonia , Kebir Mohammed , Amrane Abdeltif , Assadi Aymen Amin , Zhang Jie , Mouni Lotfi
Published: March 2023

This work aimed to formulate xanthan gum microspheres for the encapsulation of metformin hydrochloride, according to the process of ionotropic gelation. The obtained microparticles, based on various fractions of xanthan gum (0.5–1.25), were subjected to different physico-chemical tests and a drug release study. Microspheres with an average size varying between 110.96 μm and 208.27 μm were obtained. Encapsulation efficiency reached 93.11% at a 1.25% biopolymer concentration. The swelling study showed a swelling rate reaching 29.8% in the gastric medium (pH 1.2) and 360% in the intestinal medium (pH 6.8). The drug release studies showed complete metformin hydrochloride release from the beads, especially those prepared from xanthan gum at the concentration of 1.25%, in intestinal medium at 90.00% after 6 h. However, limited and insignificant drug release was observed within the gastric medium (32.50%). The dissolution profiles showed sustained release kinetics.
Design and Modelling of Graphene-Based Flexible 5G Antenna for Next-Generation Wearable Head Imaging Systems
Authors: Riaz Asad , Khan Sagheer , Arslan Tughrul
Published: March 2023

Arguably, 5G and next-generation technology with its key features (specifically, supporting high data rates and high mobility platforms) make it valuable for coping with the emerging needs of medical healthcare. A 5G-enabled portable device receives the sensitive detection signals from the head imaging system and transmits them over the 5G network for real-time monitoring, analysis, and storage purposes. In terms of material, graphene-based flexible electronics have become very popular for wearable and healthcare devices due to their exceptional mechanical strength, thermal stability, high electrical conductivity, and biocompatibility. A graphene-based flexible antenna for data communication from wearable head imaging devices over a 5G network was designed and modelled. The antenna operated at the 34.5 GHz range and was designed using an 18 µm thin graphene film for the conductive radiative patch and ground with electric conductivity of 3.5 × 105 S/m. The radiative patch was designed in a fractal fashion to provide sufficient antenna flexibility for wearable uses. The patch was designed over a 1.5 mm thick flexible polyamide substrate that made the design suitable for wearable applications. This paper presented the 3D modelling and analysis of the 5G flexible antenna for communication in a digital care-home model. The analyses were carried out based on the antenna’s reflection coefficient, gain, radiation pattern, and power balance. The time-domain signal analysis was carried out between the two antennas to mimic real-time communication in wearable devices.
Multifunctional Nanoplatform Based on Sunitinib for Synergistic Phototherapy and Molecular Targeted Therapy of Hepatocellular Carcinoma
Authors: Xu Wenjing , Yang Meng , Du Xuanlong , Peng Hao , Yang Yue , Wang Jitao , Zhang Yewei
Published: March 2023

Hepatocellular carcinoma (HCC) is a tumor that poses a serious threat to human health, with an extremely low five-year survival rate due to its difficulty in early diagnosis and insensitivity to radiotherapy and chemotherapy. To improve the therapeutic efficiency of HCC, we developed a novel multifunctional nanoplatform (SCF NPs) with an amphiphilic polymer (Ce6-PEG2000-FA) and a multitarget tyrosine kinase inhibitor sunitinib. SCF NPs showed superior therapeutical efficiency for HCC due to the synergetic effect of molecular targeted therapy and phototherapy. The Ce6-PEG2000-FA not only serves as a nanocarrier with excellent biocompatibility but also can act as a therapeutic reagent for photothermal therapy (PTT) and photodynamic therapy (PDT). Furthermore, the folic acid group of Ce6-PEG2000-FA enhanced the active targeting performance of SCF NPs. As a multitargeted tyrosine kinase inhibitor, sunitinib in SCF NPs can play a role in molecular targeted therapies, including tumor growth inhibition and anti-angiogenesis. In vivo experiments, SCF NPs showed multimode imaging capabilities, which can be used for tumorous diagnosis and intraoperative navigation. Meanwhile, SCF NPs showed outstanding synergetic tumor inhibition ability. Tumors of SCF NPs group with laser radiation were eradicated without any recrudescence after 14 days of treatment. Such theranostic nanoparticles offer a novel therapeutic tactic for HCC.
An Introduction to Nonlinear Integrated Photonics: Structures and Devices
Authors: Sirleto Luigi , Righini Giancarlo C.
Published: March 2023

The combination of integrated optics technologies with nonlinear photonics, which has led to growth of nonlinear integrated photonics, has also opened the way to groundbreaking new devices and applications. In a companion paper also submitted for publication in this journal, we introduce the main physical processes involved in nonlinear photonics applications and discuss the fundaments of this research area. The applications, on the other hand, have been made possible by availability of suitable materials with high nonlinear coefficients and/or by design of guided-wave structures that can enhance a material’s nonlinear properties. A summary of the traditional and innovative nonlinear materials is presented there. Here, we discuss the fabrication processes and integration platforms, referring to semiconductors, glasses, lithium niobate, and two-dimensional materials. Various waveguide structures are presented. In addition, we report several examples of nonlinear photonic integrated devices to be employed in optical communications, all-optical signal processing and computing, or in quantum optics. We aimed at offering a broad overview, even if, certainly, not exhaustive. However, we hope that the overall work will provide guidance for newcomers to this field and some hints to interested researchers for more detailed investigation of the present and future development of this hot and rapidly growing field.
Antibodies to Combat Fungal Infections: Development Strategies and Progress
Authors: Rabaan Ali A. , Alfaraj Amal H. , Alshengeti Amer , Alawfi Abdulsalam , Alwarthan Sara , Alhajri Mashael , Al-Najjar Amal H. , Al Fares Mona A. , Najim Mustafa A. , Almuthree Souad A. , AlShurbaji Sultan T. , Alofi Fadwa S. , AlShehail Bashayer M. , AlYuosof Buthina , Alynbiawi Ahlam , Alzayer Suha A. , Al Kaabi Nawal , Abduljabbar Wesam A. , Bukhary Zakiyah A. , Bueid Ahmed S.
Published: March 2023

The finding that some mAbs are antifungal suggests that antibody immunity may play a key role in the defense of the host against mycotic infections. The discovery of antibodies that guard against fungi is a significant advancement because it gives rise to the possibility of developing vaccinations that trigger protective antibody immunity. These vaccines might work by inducing antibody opsonins that improve the function of non-specific (such as neutrophils, macrophages, and NK cells) and specific (such as lymphocyte) cell-mediated immunity and stop or aid in eradicating fungus infections. The ability of antibodies to defend against fungi has been demonstrated by using monoclonal antibody technology to reconsider the function of antibody immunity. The next step is to develop vaccines that induce protective antibody immunity and to comprehend the mechanisms through which antibodies mediate protective effects against fungus.
Dietary Live Yeast Supplementation Influence on Cow’s Milk, Teat and Bedding Microbiota in a Grass-Diet Dairy System
Authors: Verdier-Metz Isabelle , Delbès Céline , Bouchon Matthieu , Rifa Etienne , Theil Sébastien , Chaucheyras-Durand Frédérique , Chevaux Eric , Dunière Lysiane , Chassard Christophe
Published: March 2023

The supplementation of animal feed with microbial additives remains questioning for the traditional or quality label raw milk cheeses with regard to microbial transfer to milk. We evaluated the effect of dietary administration of live yeast on performance and microbiota of raw milk, teat skin, and bedding material of dairy cows. Two balanced groups of cows (21 primiparous 114 ± 24 DIM, 18 multiparous 115 ± 33 DIM) received either a concentrate supplemented with Saccharomyces cerevisiae CNCM I-1077 (1 × 1010 CFU/d) during four months (LY group) or no live yeast (C group). The microbiota in individual milk samples, teat skins, and bedding material were analysed using culture dependent techniques and high-throughput amplicon sequencing. The live yeast supplementation showed a numerical increase on body weight over the experiment and there was a tendency for higher milk yield for LY group. A sequence with 100% identity to that of the live yeast was sporadically found in fungal amplicon datasets of teat skin and bedding material but never detected in milk samples. The bedding material and teat skin from LY group presented a higher abundance of Pichia kudriavzevii reaching 53% (p < 0.05) and 10% (p < 0.05) respectively. A significant proportion of bacterial and fungal ASVs shared between the teat skin and the milk of the corresponding individual was highlighted.