bluuebunny/crossref_metadata_2025 huggingface dataset:
Improved theoretical calculation method for the transverse load distribution of wide bridges considering torsion and distortion
Authors: Wen Ji , Ma Xinyi , Jiang Hui , Li Chen , Zeng Cong , Bai Zengqing
Published: March 2024

An improved theoretical calculation method was proposed to determine the transverse load distribution of airport and highway bridges under heavy loads using the rigid-joint girder (RJG) method. The effects of torsion, distortion, and vertical inclination of the adjacent box girder joints under an eccentric heavy load were considered. The coefficients and influence lines of a taxiway bridge and a highway bridge were calculated using the proposed method, the RJG method, and the modified RJG methods. The accuracies of the three methods were evaluated by the refined finite element model, and the cosine similarity and peak deviation rate were used as quantitative indices. The results showed that the cosine similarity obtained from the proposed method for the taxiway bridge was 0.996 compared with the finite element method (FEM). The maximum peak deviation rate of the transverse load distribution coefficient for the proposed method was 14.88 % and obviously lower than 34.74 % for the RJG method. For the highway bridge, the cosine similarity of the influence line derived from the proposed method was 0.995, and the maximum peak deviation rate of the transverse load distribution coefficient for the proposed method was 6.66 % and lower than 16.14 % for the RJG method. The results indicate that the proposed method can be used to calculate the transverse load distribution of wide box girder bridges accurately and efficiently.
The distribution law of shock wave pressure in typical trenches
Authors: Shang Fei , Wang Liangquan
Published: March 2024

Trenches, as important practical military facilities, have important theoretical and military value in evaluating the damage power of ammunition, operational application, and effective safety protection of personnel on the battlefield through the spatiotemporal evolution of explosive shock waves within them. At present, there is a lack of in-depth research on the distribution and impact of overpressure inside the trench. The paper constructed a typical finite element simulation model of a trench, numerically calculated the shock wave overpressure inside the trench and on the wall, analyzed the spatiotemporal distribution of shock wave pressure in various parts of the trench, conducted on-site explosion tests, and installed shock wave pressure sensor measurement points in the trench. The pressure time history curve was obtained, and verified and compared with the simulation calculation results. Research data shows that the peak overpressure of the shock wave in the trench increases sequentially from the front wall to the back wall. The peak overpressure of the shock wave at the front wall attenuates by 10 % to 20 % compared to the inside of the trench, and increases by 40 % to 60 % at the back wall; The peak overpressure in the trench exhibits a “V-shaped” distribution at different depths, decreasing first and then increasing as the depth increases. The maximum overpressure peak increases by 40 % to 50 % compared to the minimum; Based on simulation and measured data in the trench, as well as the distribution law of shock wave pressure, safety protection suggestions for on-site combat personnel in the trench are provided.
Experiences of community-based water supply organizations partnerships in rural areas of Colombia
Authors: Blanco-Moreno Carolina , Amaya-Domínguez Jorge , Bernal-Pedraza Andrea Yolima
Published: March 2024

Clean water for human consumption in rural areas of Latin America and the Caribbean is usually provided by community-based water supply organizations (CBWSOs). Collaborative partnerships with community-based water supply organizations (CBWSOPs) are established to tackle technical and institutional challenges concerning safe water supply. This article analyses some features of the CBWSOs and their partnerships, based on the experience of ACUANARIÑO and ASDAL – Tres Esquinas, two CBWSOs located in Valle del Cauca – Colombia, following their participation at the local, municipal (ASOOCSAS Tuluá), subnational (Asociación de Organizaciones Comunitarias Prestadoras de Servicios Públicos de Agua y Saneamiento de Colombia (AQUACOL)), national (COCSASCOL), and transnational levels (CLOCSAS). The main findings of this work, after using a participatory approach, are that initial partnerships between CBWSOs emerge from informal agreements built on the neighbourhood logic typical of rurality; however, as moving towards higher scales, agreements become more formal to allow for dialogue and discussion with governmental organizations in the water and sanitation sector. This is also a strategy for the recognition of community water management. Thus, CBWSOPs are construed under a collaborative and non-profit approach, in the manner of water operator partnerships.
La caducidad del procedimiento sancionador de conductas anticompetitivas
Authors: Tirado Barrera José Antonio
Published: March 2024

Se estudia la caducidad del procedimiento sancionador de conductas anticompetitivas, en el marco del régimen general de la ley procedimental común. El objetivo principal del artículo es constatar si en este ámbito especializado se siguen los criterios comunes de la figura de la caducidad y que vienen siendo aplicados por tribunales administrativos en otros sectores.
La recusación de los árbitros en la práctica de las principales instituciones del arbitraje internacional
Authors: Judkiewicz-Garvan Malgorzata
Published: March 2024

El presente artículo repasa las cuestiones generales relacionadas con recusación de árbitros como derecho fundamental y ofrece una recopilación de decisiones sobre recusación emitidas por tres instituciones arbitrales de alcance global, que permiten concluir que uno de los errores cometidos por las partes recusantes es aplicar el estándar subjetivo a la recusación.
ACTIN OF SMOOTH MUSCLE CELLS AS A CRITERION OF GRAVITY-SENSITIVITY OF THE GASTROINTESTINAL TRACT OF MICE AND MONGOLIAN GERBILS
Authors:   Burdenko Voronezh State Medical Universityof the Ministry of Healthcare of the Russian Federation,  Research Institute of Experimental Biology and Medicine, Voronezh, Samoilenko T.V. , Shishkina V.V. ,   Burdenko Voronezh State Medical Universityof the Ministry of Healthcare of the Russian Federation,  Research Institute of Experimental Biology and Medicine, Voronezh, Antakova L.N. ,   Burdenko Voronezh State Medical Universityof the Ministry of Healthcare of the Russian Federation,  Research Institute of Experimental Biology and Medicine, Voronezh, Goryushkina E.S. ,   Burdenko Voronezh State Medical Universityof the Ministry of Healthcare of the Russian Federation,  Research Institute of Experimental Biology and Medicine, Voronezh, Atiakshin D.А. ,   Burdenko Voronezh State Medical Universityof the Ministry of Healthcare of the Russian Federation,  Research Institute of Experimental Biology and Medicine, Voronezh
Published: March 2024

Despite the key role of the smooth muscle tissue (SMT) in the gastrointestinal organs functioning, mechanisms of SMT gravity sensitivity still remain inadequately studied in space biomedicine. Smooth muscle actin (α-SMA) was studied in membranes of the stomach and small gut fundus in mice С57BL/6N (experiment in 30-d BION-M1 mission and synchronous control BIOS-MLZh), Mongolian gerbils Meriones unguiculatus (experiment in 12-d Foton-M3 missions), and after 30-d tail-suspension according to E.R. Morey-Holton (С57BL/6N males). Immunohistochemical detection of α-SMA was conducted in 2 µm sections using the mouse SMA monoclonal antibodies (1:100, Zytomed Systems, Cat. No. MSK030). Documentary photography and analysis of micropreparations were performed with microscope ZEISS Axio Imager А2. Quantitative analysis was performed on the basis of the area of immunopositive sections using ImageJ 1.51J8. Morphometric analysis of α-SMA in muscular coat of the stomach and jejunum of the space-flown mice and gerbils detected a reduction of immunopositive sections which points to weakening of the SMT functional activity. Gravitational sensitivity of the gastrointestinal contraction structures can be conditioned by changes in structural components of actin myofilament in smooth myocytes or myofibroblasts. Absence of changes in the α-SMA expression after tail-suspension confirms that microgravity affects functional properties of the gastrointestinal muscular coats.
HEMOCOAGULATION SYSTEM IN GROUND EXPERIMENTS SIMULATING THE EFFECTS OF SPACE FLIGHT: BASED ON RUSSIAN RESEARCH MATERIALS
Authors:   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Kuzichkin D.S. , Markin А.А. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Zhuravleva О.А. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Kocherguin A.Yu. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Nichiporuk I.A. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow
Published: March 2024

The review presents the results of studying the hemocoagulation system in Soviet and Russian experiments modeling effects of some spaceflight factors on the human organism. The most adequate models of microgravity are head-down bed rest (BR) and immersion. Effects of g-loads were reproduced by rotation on a centrifuge. In the course of these experiments, the procoagulant, anticoagulant and fibrinolytic activities displayed different trends and dependence on the period of locomotion reduction. In immersion, the procoagulant activity increased, fibrinolytic activity decreased and the anticoagulant potential changed in the either direction. Some data suggest that hypergravity increases the anticoagulant and fibrinolytic activities on the background of hypocoagulation; however, there are also other data suggesting the contrary, i.e. hypergravity leads to hypercoagulation and activation of fibrinolysis. According to investigators, the combination of gravitational loads and limited locomotion decreases the procoagulant activity and increases the fibrinolytic one. Discrepancy between the post-flight and ground-based data is attributed to the impossibility to reproduce in laboratory all the factors that act on the human organism in space flight.
PROCEDURE OF CHECK TESTING IN THE PROCESS OF STUDYING THE EFFECTS OF DRY IMMERSION ON CHARACTERISTICS OF PERFORMING A MOTOR-OCULAR TASK
Authors:   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Miller N.V. , Zobova L.N. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Roshchin V.Yu. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Badakva А.М. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow
Published: March 2024

Effects of reduced support, tactile and proprioceptive afferentation on mapping and manual operating the joystick were evaluated with participation of 14 female subjects. The idea was to compare performance of a 15 minute motor-ocular task in the conditions of dry immersion and lying supine on a couch. The subjects were to direct the pointer from the screen center to one of 8 randomly emerging targets. Pointer coordinates and emergence scenarios were registered; time to reach the target and geometry of pointer trajectories were calculated. Comparison was made by 4 characteristics: latent time of reaction, time of implementing the reaction, relative trajectory length, and averaged precision of trajectory to a target and the sum of trajectories. It was found that despite some individual differences, for all participants these 4 characteristics, equally of moving to a specific target or the sum of targets, were essentially similar. The results attest to the applicability of testing supine subject's manual tracking of the pointer to a target as a baseline data collection in dry immersion experiments aimed to define whether support-deprivation impacts effectiveness of manual moving the pointer to target.
Efficacy and Safety of Pembrolizumab Monotherapy or Combined Therapy in Patients with Metastatic Triple-negative Breast Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Araghi Mahmood , Gharebakhshi Farshad , Faramarzi Fatemeh , Mafi Alireza , Mousavi Tahoora , Alimohammadi Mina , Soleimantabar Hussein
Published: March 2024

Background:

Metastatic Triple-negative Breast Cancer (mTNBC) is the most aggressive
form of breast cancer, with a greater risk of metastasis and recurrence. Research studies have
published in-depth analyses of the advantages and disadvantages of pembrolizumab, and early data
from numerous trials suggests that patients with mTNBC have had remarkable outcomes. This
meta-analysis compares the data from numerous relevant studies in order to evaluate the safety
and efficacy of pembrolizumab monotherapy or combination therapies for mTNBC.

Methods:

To identify eligible RCTs, a thorough literature search was carried out using electronic
databases. CMA software was utilized to perform heterogeneity tests using fixed and random-effects
models.

Results:

According to our pooled data, the median Progression-free Survival (PFS) was 2.66
months, and the median overall survival (OS) was 12.26 months. Furthermore, by comparing efficacy
indicators between PD-L1–positive and PD-L1–negative groups, a correlation was found between
the overexpression of PD-L1 with OS, PFS, and ORR. Patients with PD-L1-positive tumors
had a higher response rate, with an ORR of 21.1%, compared to the patients with PD-L1-negative
tumors. The ORR for first-line immunotherapy was higher than that of ≥second-line immunotherapy.
In addition, pembrolizumab plus combination treatment resulted in a pooled incidence of immune-
related adverse events of 22.7%.

Conclusion:

A modest response to pembrolizumab monotherapy was detected in the mTNBC patients.
Furthermore, a better outcome from pembrolizumab treatment may be predicted by PD-L1--
positive status, non-liver/lung metastases, combination therapy, and first-line immunotherapy.
Pembrolizumab, in combination with chemotherapy, may be more beneficial for patients whose tumors
are PD-L1 positive.
Uncovering the Emerging Prospects of Lipid-based Nanoparticulate Vehicles in Lung Cancer Management: A Recent Perspective
Authors: Gupta Dhruv Sanjay , Suares Divya
Published: March 2024

Lung cancer, a leading cause of cancer-related deaths globally, is gaining research interest
more than ever before. Owing to the burden of pathogenesis on the quality of life of patients and
subsequently the healthcare system, research efforts focus on its management and amelioration. In
an effort to improve bioavailability, enhance stability, minimize adverse effects and reduce the incidence
of resistance, nanotechnological platforms have been harnessed for drug delivery and improving
treatment outcomes. Lipid nanoparticles, in particular, offer an interesting clinical opportunity
with respect to the delivery of a variety of agents. These include synthetic chemotherapeutic agents,
immunotherapeutic molecules, as well as phytoconstituents with promising anticancer benefits. In
addition to this, these systems are being studied for their usage in conjunction with other treatment
strategies. However, their applications remain limited owing to a number of challenges, chiefly clinical
translation. There is a need to address the scalability of such technologies, in order to improve
accessibility. The authors aim to offer a comprehensive understanding of the evolution of lipid nanoparticles
and their application in lung cancer, the interplay of disease pathways and their mechanism
of action and the potential for delivery of a variety of agents. Additionally, a discussion with
respect to results from preclinical studies has also been provided. The authors have also provided a
well-rounded insight into the limitations and future perspectives. While the possibilities are endless,
there is a need to undertake focused research to expedite clinical translation and offer avenues for
wider applications in disease management.
A Prospective Metaverse Paradigm Based on the Reality-Virtuality Continuum and Digital Twins
Authors: Zare Abolfazl , Jalali Aliakbar
Published: March 2024

:

After decades of introducing the concept of virtual reality, the expansion, and significant
advances of technologies and innovations, such as 6g, edge computing, the internet of
things, robotics, artificial intelligence, blockchain, quantum computing, and digital twins, the
world is on the cusp of a new revolution. By moving through the three stages of the digital
twin, digital native, and finally surrealist, the metaverse has created a new vision of the future
of human and societal life so that we are likely to face the next generation of societies (perhaps
society 6) in the not too distant future. However, until then, the reality has been that the
metaverse is still in its infancy, perhaps where the internet was in 1990. There is still no single
definition, few studies have been conducted, there is no comprehensive and complete paradigm
or clear framework, and due to the high financial volume of technology giants, most of these
studies have focused on profitable areas such as gaming and entertainment. The motivation and
purpose of this article are to introduce a prospective metaverse paradigm based on the revised
reality-virtuality continuum and provide a new supporting taxonomy with the three dimensions
of interaction, immersion, and extent of world knowledge to develop and strengthen the theoretical
foundations of the metaverse and help researchers. Furthermore, there is still no comprehensive
and agreed-upon conceptual framework for the metaverse. To this end, by reviewing
the research literature, discovering the important components of technological building
blocks, especially digital twins, and presenting a new concept called meta-twins, a prospective
conceptual framework based on the revised reality-virtuality continuum with a new supporting
taxonomy was presented.
Exploration of the Synergistic Effects of Phytoconstituents of Ashwagandha, Amla, and Ginger as a Potent Immunity-boosting Agent for COVID-19 Affected Individuals
Authors: Sarkar Raktimava Das , Bose Aryama , Rudra Anandamoy
Published: March 2024

:

The ongoing threat of COVID-19 has prompted us to search for innovative strategies
to enhance immune responses in affected patients. Phytoconstituents derived from Ashwagandha, Amla, and Ginger have gained attention due to their historical usage in traditional medicine
and potential immune-modulatory, antioxidant, and antiviral properties. This review investigates
the synergistic effects of phytoconstituents from Ashwagandha, Amla, and Ginger to identify
potential immunity-boosting agents for COVID-19 patients. The investigation involved a comprehensive analysis of the immune-modulatory compounds present in Ashwagandha, the high
vitamin C content in Amla, and the immunomodulatory constituents in Ginger. The concept of
"phytochemical synergy" was explored, hypothesizing that their combined effects could enhance
antiviral capabilities. The combined phytoconstituents from Ashwagandha, Amla, and Ginger
demonstrated a potential synergistic interaction, suggesting an amplified immune-boosting effect. The adaptogenic properties of Ashwagandha, the rich vitamin C source in Amla, and the
immunomodulatory components of Ginger appeared to complement each other, contributing to
a holistic approach to viral resistance. While the investigation into the synergy of Ashwagandha,
Amla, and Ginger holds promise as an immunity-boosting strategy, careful consideration is warranted due to factors like appropriate dosing, safety profiles, and potential interactions with conventional treatments. This study underscores the significance of combining traditional wisdom
with modern research efforts. As the world continues to combat the complexities of COVID-19,
exploring these botanical sources serves as a reminder of the abundant resources nature offers.
While further rigorous research and clinical trials are essential, pursuing these phytoconstituents
exemplifies our commitment to exploring all viable avenues in the battle against COVID-19.
Unveiling the Compositional Analysis of Green Coffee Beans with and without Silver Skin
Authors: Tripathi Shraddha , Mishra Neha , Malaviya Ritika , Ansari Arshi , Shrimali Simran , Mishra Neetu
Published: March 2024

Background:

Green Coffee Bean (GCB) is covered with silver skin that is shed as a
by-product of the roasting process. For the first time, a comparative study was conducted to differentiate
the compositional analysis of green coffee beans with silver skin and without silver
skin.

Objective:

The study aims comparatively assessing nutritional, anti-nutritional and fatty acids
composition of green coffee beans with silver skin and without silver skin. The present study is
also intended to find out various organic compounds of green coffee beans.

Methods:

The proximate analysis was used to study nutritional composition. Mineral analysis
was assessed by atomic absorption spectroscopy. The antinutrients like phytic acid and tannin
were assessed by UV-visible spectroscopy whereas volumetric and gravimetric analysis was
used to determine oxalates and alkaloids. Gas chromatography and Fourier Transform Infra-Red
spectroscopy were used for studying fatty acids and organic compounds, respectively.

Results:

Protein content was significantly (p<0.05) high in green coffee beans with silver skin,
indicating 15% higher protein. Macro mineral content was also found significantly (p<0.05 and
p<0.01) high in green coffee beans with silver skin, whereby 5.11% higher Phosphorus and
24.12% higher Calcium content was observed. However, iron content was 68.10% lower in
green coffee beans with silver skin which might be due to its higher tannin content. Trace minerals
zinc and copper were also found to contain 57.18% to 18.11% higher concentrations respectively
in silver skin. Anti-nutritional analysis revealed the content of phytic acid and tannin
as 161 and 77.29 mg/100g, respectively in green coffee beans with silver skin. The percentages
of oxalates and alkaloids were found to be 0.64 and 14.30. These anti-nutritional compounds
were significantly (p<0.05 and p<0.01) higher from green coffee beans without silver skin.
Green coffee beans have been found with an utmost number of saturated fatty acids having palmitic
acid as the most abundant. The unsaturated part is mainly composed of linoleic and oleic
acid. Chlorogenic acid isomers and caffeine were the organic compounds detected through Fourier
transform infrared spectroscopy.

Conclusion:

These findings reveal the presence of both nutritional and anti-nutritional components
in Coffee silver skin, with significantly higher levels of anti-nutritional factors in green
coffee with silver skin, emphasizing the need for caution in the consumption of green coffee and
utilization of coffee silver skin as a valuable bioresource.
Strategies of Displacement in Artists’ Periodicals from the 1970s: Neon de Suro, Schmuck, Commonpress, and La Città di Riga
Authors: Boivent Marie , Di Domenico Giorgio
Published: March 2024

During the 1960s and 1970s, artists’ periodicals flourished as a new artistic medium. Strikingly, artists behind these alternative publications often claimed a peripheral position, assuming a geographical anchorage far from the capitals and main artistic centres. This paper addresses how the notion of periphery manifests itself in four European artists’ periodicals published during the 1970s. It will focus on their distribution strategies, their ideological positioning, the works they disseminated, and the artists’ writings and statements they featured. First, the analysis of three European alternative periodicals — Neon de Suro (Spain, 1975–82), Schmuck Magazine (England, 1972–76), and Commonpress (Poland, 1977–91) — will highlight how a peripheral position far from the capitals and the main artistic poles could become a strength, even a real editorial strategy. Such preoccupations were not, however, reserved for artists outside the official art scene: the question of periphery also found its place, albeit in different ways, in more institutionalized periodicals. This will be evident in the case of the Italian periodical La Città di Riga (1976–77), the focus of the second part of this paper, which negotiated the idea of centre and periphery right from its name. Through the case studies of these four periodicals and the analysis of coeval theoretical contributions, this paper aims to shape an elastic notion of the relationship between centre and periphery, at the same time derived from and applicable to the experimental editorial strategies of artists’ periodicals from the 1970s.
Introduction: Latin–Greek Code-switching in Early Modernity
Authors: Barton William Michael , Van Rooy Raf
Published: March 2024

This article is the introduction to theforthcoming set of special issues on code-switching in early modernity. Theintroduction begins with an overview of code-switching as an instrumentinherited by literary scholars from the field of linguistics. On this basis,the introduction then provides a summary of the practices of Latin–Greekcode-switching in classical literature. This classical precedence served inearly modernity as a starting point for authors of Latin and Greek texts intheir own compositions, but it serves also today as a starting point forscholars interested in the ancient languages now turning to code-switching inearly modern literature. The final section of this introduction presents anoverview of the key themes and concepts explored in the forthcoming specialissue. It highlights the benefits of the concept of code-switching forunderstanding early modern uses of Latin and Greek, only now emerging as atheme of dedicated research in Neo-Latin and New Ancient Greek studies.@font-face{font-family:"Cambria Math";panose-1:2 4 5 3 5 4 6 3 2 4;mso-font-charset:0;mso-generic-font-family:roman;mso-font-pitch:variable;mso-font-signature:-536870145 1107305727 0 0 415 0;}@font-face{font-family:Calibri;panose-1:2 15 5 2 2 2 4 3 2 4;mso-font-charset:0;mso-generic-font-family:swiss;mso-font-pitch:variable;mso-font-signature:-469750017 -1073732485 9 0 511 0;}p.MsoNormal, li.MsoNormal, div.MsoNormal{mso-style-unhide:no;mso-style-qformat:yes;mso-style-parent:"";margin:0cm;mso-pagination:widow-orphan;font-size:12.0pt;font-family:"Calibri",sans-serif;mso-ascii-font-family:Calibri;mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font:minor-latin;mso-hansi-font-family:Calibri;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:"Times New Roman";mso-bidi-theme-font:minor-bidi;mso-ansi-language:EN-GB;mso-fareast-language:EN-US;}.MsoChpDefault{mso-style-type:export-only;mso-default-props:yes;font-family:"Calibri",sans-serif;mso-ascii-font-family:Calibri;mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font:minor-latin;mso-hansi-font-family:Calibri;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:"Times New Roman";mso-bidi-theme-font:minor-bidi;mso-font-kerning:0pt;mso-ligatures:none;mso-fareast-language:EN-US;}div.WordSection1{page:WordSection1;}
Impact of Sex and Gender Differences on Heart Failure, Especially in Elderly Patients
Authors: Cocco Giuseppe , Hofmann Hans Peter , Pandolfi Stefano
Published: March 2024

Heart failure is one of the major health threats in Western societies, and its prevalence is steadily increasing. Many data show the important impact of sex (biological) and gender (sociocultural) differences on most aspects (diagnosis, etiology, treatments, and outcomes) of heart failure. For example, compared to men, women with heart failure are older, have more co-morbidities, and develop different phenotypes of heart failure. Postpartum cardiopathy is unique in women. The iatrogenic effects of cancer therapies are more frequent among women compared to men. Currently, the integration of sex and gender differences into the therapy of heart failure is rare. Consequently, women derive disadvantages from a nonspecifically adapted therapy for heart failure, get worse outcomes, and have more iatrogenic adverse effects than men. This situation is medically unfortunate and increases medical expenditures. A sex-guided approach to the correct evaluation of patients with heart failure should become the cornerstone for the correct management of these patients.
Acceptance of a French e–Mental Health Information Website (CléPsy) for Families: A Web-Based Survey
Authors: Landman Benjamin , Khoury Elie , Cohen Alicia , Trebossen Vincent , Michel Alexandre , Lefebvre Aline , Delorme Richard
Published: March 2024

Background

Childhood mental health issues concern a large amount of children worldwide and represent a major public health challenge. The lack of knowledge among parents and caregivers in this area hinders effective management. Empowering families enhances their ability to address their children’s difficulties, boosts health literacy, and promotes positive changes. However, seeking reliable mental health information remains challenging due to fear, stigma, and mistrust of the sources of information.

Objective

This study evaluates the acceptance of a website, CléPsy, designed to provide reliable information and practical tools for families concerned about child mental health and parenting.

Methods

This study examines user characteristics and assesses ease of use, usefulness, trustworthiness, and attitude toward using the website. Platform users were given access to a self-administered questionnaire by means of mailing lists, social networks, and posters between May and July 2022.

Results

Findings indicate that the wide majority of the 317 responders agreed or somewhat agreed that the website made discussions about mental health easier with professionals (n=264, 83.3%) or with their relatives (n=260, 82.1%). According to the ANOVA, there was a significant effect between educational level and perceived trust (F6=3.03; P=.007) and between frequency of use and perceived usefulness (F2=4.85; P=.008).

Conclusions

The study underlines the importance of user experience and design in web-based health information dissemination and emphasizes the need for accessible and evidence-based information. Although the study has limitations, it provides preliminary support for the acceptability and usefulness of the website. Future efforts should focus on inclusive co-construction with users and addressing the information needs of families from diverse cultural and educational backgrounds.
Evaluation of Large Language Model Performance and Reliability for Citations and References in Scholarly Writing: Cross-Disciplinary Study
Authors: Mugaanyi Joseph , Cai Liuying , Cheng Sumei , Lu Caide , Huang Jing
Published: March 2024

Background

Large language models (LLMs) have gained prominence since the release of ChatGPT in late 2022.

Objective

The aim of this study was to assess the accuracy of citations and references generated by ChatGPT (GPT-3.5) in two distinct academic domains: the natural sciences and humanities.

Methods

Two researchers independently prompted ChatGPT to write an introduction section for a manuscript and include citations; they then evaluated the accuracy of the citations and Digital Object Identifiers (DOIs). Results were compared between the two disciplines.

Results

Ten topics were included, including 5 in the natural sciences and 5 in the humanities. A total of 102 citations were generated, with 55 in the natural sciences and 47 in the humanities. Among these, 40 citations (72.7%) in the natural sciences and 36 citations (76.6%) in the humanities were confirmed to exist (P=.42). There were significant disparities found in DOI presence in the natural sciences (39/55, 70.9%) and the humanities (18/47, 38.3%), along with significant differences in accuracy between the two disciplines (18/55, 32.7% vs 4/47, 8.5%). DOI hallucination was more prevalent in the humanities (42/55, 89.4%). The Levenshtein distance was significantly higher in the humanities than in the natural sciences, reflecting the lower DOI accuracy.

Conclusions

ChatGPT’s performance in generating citations and references varies across disciplines. Differences in DOI standards and disciplinary nuances contribute to performance variations. Researchers should consider the strengths and limitations of artificial intelligence writing tools with respect to citation accuracy. The use of domain-specific models may enhance accuracy.
FACTORS ASSOCIATED WITH SILENT ISCHEMIA IN TYPE 2 DIABETIC PATIENTS
Authors: A Vashisth , S Sharma , R N Patel , P K GUPTA
Published: March 2024

Objective: The present study was conducted to study the role of treadmill testing (TMT) in identifying silent ischemia in diabetic patients and to assess factors associated with silent ischemia in them.
Methods: The study was a hospital-based cross-sectional study where 60 patients with type 2 diabetes between the age 40 and 60 years without an established clinical diagnosis of coronary artery disease attending medical OPD were included in the study. The TMT was done using a computerized CTMT machine with built-in protocols. Continuous electrocardiogram (ECG) recordings were taken.
Results: The prevalence of silent myocardial ischemia in type 2 asymptomatic diabetes mellitus in this study was found to be 28.3%. Smoking, higher age, alcohol intake, and duration of DM were found to be significantly associated with silent myocardial ischemia.
Conclusion: Thus, we conclude that the prevalence of silent myocardial ischemia is more common in diabetics. Early screening of asymptomatic patients with type 2 diabetes mellitus with the help of TMT for evidence of silent myocardial ischemia may prevent catastrophic cardiac events.
A RANDOMIZED STUDY ANALYZING CLINICAL AND DOSIMETRIC OUTCOME IN LOCALLY ADVANCED HEAD-AND-NECK CANCER TREATED WITH CONFORMAL CHEMORADIATION WITH OR WITHOUT INDUCTION CHEMOTHERAPY
Authors: ABHISHEK BASU  , BIDYUT MANDAL  , ANNESHA SEN  , JANMENJOY MONDAL
Published: March 2024

Objective: Squamous cell carcinoma of the head and neck (HNSCC) represents around 10% of new cases in India annually and with a similar trend worldwide. Treatment strategies for stages III and IV HNSCC differ in view of resectability, organ preservation, and medical conditions. Induction chemotherapy (IC) followed by concomitant chemoradiation (CTRT) is widely practiced but Indian data regarding clinical outcomes in the IGRT scenario is still not promising. In this study, we tried to evaluate the dosimetric parameters, response rate, survival, and toxicities as well.
Methods: We started our study in August 2019 with Institutional Ethical Committee approval with 42 patients in the CTRT arm and 40 patients in IC+CTRT arm. Patients in the CTRT arm received radiation (66–70 Gy) with 3 weekly cisplatin 80 mg/m2. In the induction arm, 2 cycles of taxane, platinum, 5FU were given followed by concomitant radiotherapy with the same dose and cisplatin.
Results: Overall response rates (CR+PR) were 69% versus 72.5% (p=0.06). 2 years overall survival (OS) were 66.7% versus 69.5% (p=0.91). Median disease-free survival were slightly better in the IC+CTRT arm but mean OS was comparable. Mean values of clinical target volume, planning target volume, Spine Dmax, and parotid were lower in the induction arm (p<0.05). Patients with IC experienced more hematological toxicities (p<0.01).
Conclusion: IC followed by CTRT offers better dosimetric outcome, slightly better progression-free survival, with more hematological toxicities and no OS benefit.
Los cactus: patrimonio natural de México
Authors: Rosas Aguilar Sharon Amairany , Solórzano Lujano Sofía
Published: March 2024

Los cactus son plantas terrestres que se distribuyen principalmente en las zonas áridas del continente americano y las islas del Caribe, aunque también se encuentran en ambientes no áridos desde Canadá hasta Tierra del Fuego. La mayoría de las 1,500 especies de cactus son nativas del continente americano y únicamente Rhipsalis baccifera tiene distribución natural en el viejo continente. México contiene la mayor riqueza a nivel mundial con casi 700 especies. Los cactus proveen múltiples beneficios ecosistémicos, ya que reducen los impactos de la desertificación, tienen interacciones ecológicas y tróficas con otros organismos. Algunas especies median o favorecen el establecimiento de otras plantas, facilitan la permeación del agua hacia los mantos freáticos y disminuyen la erosión del suelo, así como también tienen usos alimentarios y medicinales. La mayoría de las cactáceas enfrentan riesgos de supervivencia debido a la pérdida y fragmentación de los hábitats naturales, así como la extracción intensiva para el comercio ilícito. Existen leyes mexicanas y acuerdos internacionales para conservar y proteger a los cactus y los ambientes en donde ocurren. Todos podemos contribuir con buenas prácticas comerciales para adquirir cactus legalmente y así ayudar a su conservación.
KEMATANGAN EMOSI DENGAN AGGRESSIVE DRIVING PADA MAHASISWA
Authors: Muhaz Muhammad
Published: March 2024

Aggressive driving merupakan penyebab utama terjadinya kecelakaan lalu lintas di dunia yang telah banyak menyebabkan korban meninggal dunia di jalan, dan kematangan emosi merupakan salah satu faktor yang diduga terkait dengan terjadinya aggressive driving. Tujuan dari penelitian ini adalah untuk mengetahui hubungan antara kematangan emosi dengan aggressive driving yang dilakukan oleh mahasiswa. Desain yang digunakan adalah non-eksperimen kuantitatif dengan menggunakan skala kematangan emosi dan skala aggressive driving. Jumlah subyek sebanyak 385 orang dengan menggunakan teknik nonrandom sampling dalam pengambilan samplenya. Hasil penelitian menunjukkan terdapat hubungan negatif yang sangat signifikan antara kematangan emosi dengan aggressive driving, dengan nilai r sebesar -0,371 dan nilai p= 0,000. Hal ini berarti semakin tinggi kamatangan emosi mahasiswa maka akan semakin rendah aggressive driving yang dilakukan.Kata kunci: Kematangan emosi, aggressive driving, mahasiswa
PROFIL KEPRIBADIAN PELAKU BULLYING
Authors: Utami M. Alfian
Published: March 2024

Kekerasan yang terjadi akhir-akhir ini telah melibatkan siswa baik sebagai pelaku maupun korbannya. Kekerasan yang terjadi dapat berakibat tidak baik pada pelaku maupun korban. Kenyataan tidak semua remaja berposisi sebagai pelaku bullying. Hal ini menjadi landasan penelitian yang dilakukan dengan tujuan untuk memahami profil kepribadian pelaku bullying didasarkan pada need yang berkembang pada pelaku. Subjek penelitian adalah siswa yang merupakan pelaku bullying dengan rentang usia antara 15-19 tahun dengan teknik purposive dan didapatkan 12 remaja. Identifikasi need subjek dengan menggunakan EPPS (Edward Personal Preference Schedule). Analisis data menggunakan deskriptif kuantitatif. Hasil penelitian didapatkan bahwa faktor need pelaku bullying secara berurutan didominasi oleh Need order (58,33%) Need Nurture (58,33%) serta Need Heterosexual (91,67%) yang tergolong ekstrim rendah. Begitu juga dengan pelaku yang didominasi oleh laki yakni 75%, sedangkan perempuan 25%. Selain itu hasil penelitian didapat bahwa ada perbedaan antara pelaku laki-laki dan perempuan dimana pelaku laki-laki cakupannya lebih luas dibandingkan perempuan dalam hal tempat kejadian, modus, serta karakteristik korban yang akan dijadikan sebagai target bullying.Kata kunci: Profil kepribadian, bullying
SELF DISCLOSURE TERHADAP PASANGAN MELALUI MEDIA FACEBOOK DI TINJAU DARI JENIS KELAMIN
Authors: Nugroho Ditya Ardi
Published: March 2024

Self disclosure merupakan kegiatan membagi perasaan dan informasi yang akrab kepada orang lain. Tujuan penelitian ini adalah untuk mengetahui perbedaan self disclosure terhadap pasangan melalui media facebook di tinjau dari jenis kelamin. Desain yang digunakan adalah desain deskriptif kuantitatif dan menggunakan skala self disclosure. Jumlah subyek 60 orang, usia 16 - 18 tahun, kelas X. Hasil penelitian ini menunjukkan bahwa terdapat perbedaan self disclosure melalui media facebook ditinjau dari jenis kelamin. Self disclosure pada perempuan lebih tinggi daripada self disclosure laki - laki. Perbedaan dari kedua kelompok sangat signifikan.Kata kunci: Self disclosure, jenis kelamin, facebook
Encouragement Policies and Productivity Indicators for Colombian SMEs Using Data Envelopment Analysis and Malmquist Indexes
Authors: García Camacho Manuel Eduardo , Anido R. José Daniel
Published: March 2024

Purpose: This study aimed to characterize the performance of Colombian Micro, Small, and Medium-sized Enterprises (MSMEs) in recent years, along with the legal framework and central public policies governing and promoting this business segment. In addition, it sought to design, validate, and implement a dynamic system of productivity indicators to help these companies improve their efficiency and competitiveness in the short, medium, and long terms. MSMEs represent approximately 99% of the business sector in Colombia, accounting for nearly 80% of national employment. 
Design/Methodology: In the initial descriptive–analytical phase, using secondary sources, an analysis was conducted on the performance and current situation of Colombian MSMEs, as well as the main legal provisions regulating and contributing to their development. The subsequent phase (of an applied nature) involved estimating and validating a dynamic system of productivity indicators using Data Envelopment Analysis (DEA) and Malmquist indexes for 2 samples of SMEs.
Findings: After conducting the DEA, a significant decrease was observed in the productivity of the MSMEs, particularly in terms of technical efficiency in both the Constant Returns to Scale (CRS) and Variable Returns to Scale (VRS) models. This means that, evaluated both under the CRS and VRS modes, these enterprises use more inputs than necessary for the amount of goods produced. In addition, the Malmquist indexes showed that, during the period under analysis, technical efficiency related to changes in innovation exhibited a positive behavior, attributed to the incorporation of technological changes for improving their productivity.
Conclusions: Despite the development of public initiatives and institutional support in recent decades, Colombian SMEs still face adverse conditions that affect their competitiveness and limit their potential in the national economy. The proposed system of indicators, which is based on DEA techniques and Malmquist indexes, holds promise in helping these businesses to improve their productivity. 
Originality: This study makes a significant contribution to the fields of economics and business management in the region by providing a critical and updated evaluation of the efficiency of MSMEs in Colombia. Additionally, it examines their performance and current situation and summarizes the main legal provisions regulating and contributing to their development in the country.
Nowicjusz w pracy resocjalizacyjnej z nieletnim Stawanie się wychowawcą (analiza case study)
Authors: Cieślikowska-Ryczko Angelika , Dobińska Gabriela
Published: March 2024

W podjętym artykule skoncentrowano się na procesie wchodzenia w rolę pedagoga resocjalizacyjnego z perspektywy nowo zatrudnionych wychowawców. Opierając się na analizie case study dokonano rekonstrukcji procesu stawania się wychowawcą/wychowawczynią w wybranych placówkach resocjalizacyjnych dla nieletnich. Obrana perspektywa badawcza przyczyniła się do scharakteryzowania trudności oraz sposobów radzenia sobie z nimi przez pedagogów posiadających krótki staż zawodowy. Istotnym wkładem jest uchwycona w tokubadań „męska” i „kobieca” perspektywa pracy. W poczynionych analizach ważny był nie tylko status nowicjusza, ale także zaobserwowane różnice między realizacją i wdrażaniem do rolizawodowej z punktu widzenia kobiety i mężczyzny.
The Hoechst Side Population Cells can be Effectively Detected by 375nm and 405nm Lasers
Authors: Wang Fangfang , Zhai Xinyu , Guo Tingting , Xiao Hengyi , Huang Jingcao
Published: March 2024

The side population (SP) cells are identified through Hoechst 33342
staining and analyzed using flow cytometry (FCM). The Hoechst SP method
is utilized for the isolation of stem cells based on the dye efflux
properties of ATP-binding cassette (ABC) transporters. This method was
initially employed for the identification and isolation of hematopoietic
stem cells (HSCs), but it has now evolved to primarily focus on the
identification and isolation of cancer stem cells (CSCs). In this study,
the capability of the 375 nm and 405 nm lasers in detecting SP cells was
assessed and compared with that of the 355nm laser. Our findings
demonstrate a remarkable similarity between the SP cells detected by the
355nm laser and the 405nm laser on the CytoFLEX system of FCM. These
results suggest that the high-power 375 nm and 405 nm lasers can serve
as a viable alternative to the 355 nm laser for SP cell detection.
Convergent evolution on oceanic islands: comparative genomics reveals species-specific processes in birds
Authors: Recuerda María , Montoya Julio César Hernández , Blanco Guillermo , Milá Borja
Published: March 2024

Understanding the factors driving phenotypic and genomic differentiation
of insular populations is of major interest to gain insight into the
speciation process. Comparing patterns across different insular taxa
subjected to similar selective pressures upon colonizing oceanic islands
provides the opportunity to study parallel evolution and identify shared
patterns in their genomic landscapes of differentiation. We selected
four species of passerine birds (common chaffinch Fringilla
coelebs/canariensis, red-billed chough Pyrrhocorax pyrrhocorax,
house finch Haemorhous mexicanus and dark-eyed/island junco
Junco hyemalis/insularis) that have both mainland and insular
populations. For each species, we sequenced whole genomes from mainland
and insular individuals to infer their demographic history, characterize
their genomic differentiation, and identify the factors shaping them. We
estimated the relative (F) and absolute
(d) differentiation, nucleotide diversity (π),
Tajima’s D, gene density and recombination rate. We also searched for
selective sweeps and chromosomal inversions along the genome. Changes in
body size between island and mainland were consistent with the island
rule. All species shared a marked reduction in effective population size
(N) upon island colonization. We found highly
differentiated genomic regions in all four species, suggesting the role
of selection in island-mainland differentiation, yet the lack of
congruence in the location of these regions indicates that each species
adapted to insular environments differently. Our results suggest that
the genomic mechanisms involved, which include selective sweeps,
chromosomal inversions, and historical factors like recurrent selection,
differ in each species despite the highly conserved structure of avian
genomes and the similar selective factors involved.
Kierunki wydatkowania środków pieniężnych z dopłat bezpośrednich
Authors: Smolarski Leonard
Published: March 2024

Celem badań było określenie kierunków wydatkowania i sposobów rozdysponowania środków pieniężnych pochodzących z dopłat bezpośrednich w indywidualnych gospodarstwach rolniczych. (fragment tekstu)
Dochody budżetu państwa w latach 2000-2008
Authors: Adamowicz Mieczysław , Wawrzonkiewicz Małgorzata
Published: March 2024

Celem artykułu jest analiza wielkości oraz dynamiki dochodów budżetu państwa w latach 2000-2008 w oparciu o sprawozdania Ministerstwa Finansów z wykonania budżetu państwa. W artykule tym zostały pokazane prognozy oraz realizacja dochodów budżetu państwa, a także źródła ich uzyskania. Ponadto, zwrócono uwagę na relację dochodów budżetu państwa do PKB. (fragment tekstu)