bluuebunny/crossref_metadata_2025 huggingface dataset:
FUS regulates a subset of snoRNA expression and modulates the level of rRNA modifications
Authors: Gawade Kishor , Plewka Patrycja , Häfner Sophia J. , Lund Anders H. , Marchand Virginie , Motorin Yuri , Szczesniak Michal W. , Raczynska Katarzyna D.
Published: February 2023

FUS is a multifunctional protein involved in many aspects of RNA metabolism, including transcription, splicing, translation, miRNA processing, and replication-dependent histone gene expression. In this work, we show that FUS depletion results in the differential expression of numerous small nucleolar RNAs (snoRNAs) that guide 2’-O methylation (2’-O-Me) and pseudouridylation of specific positions in ribosomal RNAs (rRNAs) and small nuclear RNAs (snRNAs). Using RiboMeth-seq and HydraPsiSeq for the profiling of 2’-O-Me and pseudouridylation status of rRNA species, we demonstrated considerable hypermodification at several sites in HEK293T and SH-SY5Y cells with FUS knockout (FUS KO) compared to wild-type cells. We observed a similar direction of changes in rRNA modification in differentiated SH-SY5Y cells with the FUS mutation (R495X) related to the severe disease phenotype of amyotrophic lateral sclerosis (ALS). Furthermore, the pattern of modification of some rRNA positions was correlated with the abundance of corresponding guide snoRNAs in FUS KO and FUS R495X cells. Our findings reveal a new role for FUS in modulating the modification pattern of rRNA molecules, that in turn might generate ribosome heterogeneity and constitute a fine-tuning mechanism for translation efficiency/fidelity. Therefore, we suggest that increased levels of 2’-O-Me and pseudouridylation at particular positions in rRNAs from cells with the ALS-linked FUS mutation may represent a possible new translation-related mechanism that underlies disease development and progression.
Impacts of water hardness and road deicing salt on zooplankton survival and reproduction
Authors: Woodley Aniyah , Hintz Leslie L. , Wilmoth Bayley , Hintz William D.
Published: February 2023

Rising salinity from road deicing salts threatens the survival and reproduction of freshwater organisms. We conducted two experiments to address how Daphnia pulex survival and reproduction were affected by road salt concentration (control, 120, 640 and 1200 mg Cl−/L) crossed with three concentrations of water hardness (20, 97, 185 mg CaCO3 /L). D. pulex survival was poor in our hard water treatment in both experiments (185 mg CaCO3 /L), potentially indicating a low tolerance to hard water for the strain used in our experiments. With the remaining two hardness treatments (20 and 97 mg CaCO3 /L), we found no evidence of an interactive effect between salt concentration and water hardness on D. pulex survival. In our population-level experiment, D. pulex survival was reduced by > 60% at 120 mg Cl−/L compared to the control. In the individual experiment, survival was similar between the control and 120 mg Cl−/L, but ≤ 40% of individuals survived in 640 and 1200 mg Cl−/L. For the surviving individuals across all treatments, the number of offspring produced per individual declined with increasing Cl− concentration and in hard water. Our results indicate that current Cl− thresholds may not protect some zooplankton and reduced food availability per capita may enhance the negative impacts of road salt.
A new method for axis adjustment of the hydro-generator unit using machine learning
Authors: Cao Jie , Li Yang , Qu Zhaoyang , Dong Yunchang , Liu Yaowei , Zhang Ruxuan
Published: February 2023

The power quality and efficiency of the hydro-power station depend on the stable operation of the hydro-generator unit, which needs to continue to operate and it is prone to axis failure. Therefore, to adopt effective axis adjustment technology to eliminate faults. This paper proposes a new method for axis adjustment of hydro-generator unit based on an improved grey prediction model and swarms intelligence optimization neural network. First of all, it proposes a sequence acceleration translation and mean value transformation method, which is used to pre-process the axis net total swing sequence that exhibits oscillating fluctuations. It uses e1 and e2 factor transformation to establish an improved axis net total swing gray prediction model. Then, the advanced flamingo search algorithm is used to search the maximum value of the sine function of the net total pendulum of the axis, and the axis adjustment orientation is obtained. This method solves the problem that GM(1, 1) can only be predicted by monotone sequence in the past and the problem that the search algorithm is easy to fall into local optimum, effectively improves the calculation efficiency of axis and shorts the search time. Simulation examples show that the proposed method can significantly improve accuracy of axis adjustment. This method greatly improves the efficiency of azimuth search for axis adjustment.
Identification and prediction of mixed-use functional areas supported by POI data in Jinan City of China
Authors: Zheng Minrui , Wang Hongyu , Shang Yiqun , Zheng Xinqi
Published: February 2023

The urban development of China is changing from incremental expansion to stock renewal mode. The study of urban functional areas has become one of the important fundamental works in current urban renewal and high-quality urban development. In recent years, big spatiotemporal data has been well applied in the urban function field. However, the study of spatial–temporal evolution characteristics and forecasting optimization for mixed-use urban functional areas has not been examined well. Thus, in this study, we proposed a new approach that applies a revised information entropy method to analyze the degrees of mixing for urban functional areas. We applied our approach in Jinan City, Shandong Province as the study area. We used Point-of-Interest, OpenStreetMap and other datasets to identify the mixed-use urban functional areas in Jinan. Then, the CA–Markov model simulated the urban layout in 2025. The results showed that: (1) the combination of road network and kernel density method has the highest accuracy of identifying urban functional areas. (2)The mixing degree model is constructed by using the improved information entropy, which makes up for the shortcoming of identifying the mixed functional areas simply by the frequency ratio of POI data. (3) The “residence and business” functional area has the highest proportion in the central area of Jinan from 2015 to 2020, and the total area of mixed-use unban functional areas continuously increased during this period. (4) The total area of the central area in Jinan has significantly increased in 2025. The optimization of urban functions should expand mixed-use functional areas and increase the proportion of infrastructure. Also, Jinan should improve the efficiency of space development.
The diagnostic and prognostic utility of repetitive nerve stimulation in patients with myasthenia gravis
Authors: Tomschik Matthias , Renaud Eva , Jäger Fiona , Paternostro Chiara , Rath Jakob , Rinner Walter , Zulehner Gudrun , Zimprich Fritz , Cetin Hakan
Published: February 2023

Repetitive nerve stimulation (RNS) is a standard test for the diagnosis of myasthenia gravis (MG), where decrement of compound muscle action potentials (CMAP) corresponds to clinical muscle fatigability. Our aim was to ascertain the diagnostic and prognostic utility of RNS in MG patients. This study included MG patients treated between 01/2000 and 12/2016, with an observational period of at least one year and a minimum of two neurological examinations. Clinical and electrophysiological data were retrospectively gathered from patient records, and CMAP decrement was correlated with autoantibody titers and clinical disease severity at different time points. Ninety-four patients were included, with 88.3% of the cohort testing positive for acetylcholine receptor autoantibodies (AChR-Abs). RNS sensitivity was higher in patients with generalized disease (71.6%) than in purely ocular MG (38.5%). CMAP decrement did not significantly correlate with AChR-Ab titers, nor with clinical symptom severity at the time of testing or last follow up. However, there was a significant correlation between CMAP decrement and the worst recorded clinical status on a group level. RNS testing is more sensitive in generalized disease and AChR-Ab positive patients, but our data do not support RNS as a tool for long-term outcome prediction. Future studies with a prospective study design could help to overcome a number of limiting factors discussed in our study.
A spectroscopic and quantum chemical calculation method for the characterisation of metal ions complexed with propyl gallate and procyanidins
Authors: Zhang Liangliang , Guan Qinhao , Zhang He , Tang Lihua , Xu Man
Published: February 2023

The deprotonation mechanism for the phenolic hydroxyl and the complexing of metal ions with a commonly used food additive, propyl gallate (PG) were studied theoretically and experimentally. The interaction of procyanidins [PC, epicatechin16 (4 → 8) catechin], and its basic monomeric unit catechin (CA) with metal ions was studied by the fluorescence quenching spectra. The results showed that the 9-OH quinoid PG was formed at higher pH (10.9) by the oxidization of phenolic hydroxyl. The binding affinities (Ka) and stoichiometry of these metal ions with PG were determined. The Al3+ in PG-Al complex [Al(PG)(H2O)2Cl2]- was coordinated at the 8,9-OH doubly deprotonated catechol site with double chloride ions (Cl-) and double water molecules (H2O). The fluorescence quenching titration with Sn2+, Zn2+, Cu2+, Al3+ and Fe3+ revealed that the stoichiometries of metal-bound PC were 1:1, 2:3, 2:3, 2:3 and 1:1, respectively. The presence of bovine serum albumin (BSA) could enhance the complexing strength of PC with metal ions.
Sense of doubt: inaccurate and alternate locations of virtual magnetic displacements may give a distorted view of animal magnetoreception ability
Authors: Schneider Will T. , Packmor Florian , Lindecke Oliver , Holland Richard A.
Published: February 2023

Virtual magnetic displacements are used to examine the magnetoreceptive ability of animals by changing the local magnetic field to emulate one that exists elsewhere. This technique can be used to test whether animals use a magnetic map. The viability of a magnetic map is dependant upon which magnetic parameters an animal’s coordinate system is composed of, and how sensitive they are to those parameters. Previous research has not considered the degree to which sensitivity can change an animal’s impression of where a virtual magnetic displacement is located. We re-assessed all published studies that use virtual magnetic displacements assuming the highest likely level of sensitivity to magnetic parameters in animals. The vast majority are susceptible to the existence of alternate possible virtual locations. In some cases, this can cause results to become ambiguous. We present a tool for visualising all possible virtual magnetic displacement alternative locations (ViMDAL) and propose changes to how further research on animal magnetoreception is conducted and reported.
Single-cell transcriptome sequencing allows genetic separation, characterization and identification of individuals in multi-person biological mixtures
Authors: Kulhankova Lucie , Montiel González Diego , Bindels Eric , Kling Daniel , Kayser Manfred , Mulugeta Eskeatnaf
Published: February 2023

Identifying individuals from biological mixtures to which they contributed is highly relevant in crime scene investigation and various biomedical research fields, but despite previous attempts, remains nearly impossible. Here we investigated the potential of using single-cell transcriptome sequencing (scRNA-seq), coupled with a dedicated bioinformatics pipeline (De-goulash), to solve this long-standing problem. We developed a novel approach and tested it with scRNA-seq data that we de-novo generated from multi-person blood mixtures, and also in-silico mixtures we assembled from public single individual scRNA-seq datasets, involving different numbers, ratios, and bio-geographic ancestries of contributors. For all 2 up to 9-person balanced and imbalanced blood mixtures with ratios up to 1:60, we achieved a clear single-cell separation according to the contributing individuals. For all separated mixture contributors, sex and bio-geographic ancestry (maternal, paternal, and bi-parental) were correctly determined. All separated contributors were correctly individually identified with court-acceptable statistical certainty using de-novo generated whole exome sequencing reference data. In this proof-of-concept study, we demonstrate the feasibility of single-cell approaches to deconvolute biological mixtures and subsequently genetically characterise, and individually identify the separated mixture contributors. With further optimisation and implementation, this approach may eventually allow moving to challenging biological mixtures, including those found at crime scenes.
FLI1 and FRA1 transcription factors drive the transcriptional regulatory networks characterizing muscle invasive bladder cancer
Authors: Guneri-Sozeri Perihan Yagmur , Özden-Yılmaz Gülden , Kisim Asli , Cakiroglu Ece , Eray Aleyna , Uzuner Hamdiye , Karakülah Gökhan , Pesen-Okvur Devrim , Senturk Serif , Erkek-Ozhan Serap
Published: February 2023

Bladder cancer is mostly present in the form of urothelium carcinoma, causing over 150,000 deaths each year. Its histopathological classification as muscle invasive (MIBC) and non-muscle invasive (NMIBC) is the most prominent aspect, affecting the prognosis and progression of this disease. In this study, we defined the active regulatory landscape of MIBC and NMIBC cell lines using H3K27ac ChIP-seq and used an integrative approach to combine our findings with existing data. Our analysis revealed FRA1 and FLI1 as two critical transcription factors differentially regulating MIBC regulatory landscape. We show that FRA1 and FLI1 regulate the genes involved in epithelial cell migration and cell junction organization. Knock-down of FRA1 and FLI1 in MIBC revealed the downregulation of several EMT-related genes such as MAP4K4 and FLOT1. Further, ChIP-SICAP performed for FRA1 and FLI1 enabled us to infer chromatin binding partners of these transcription factors and link this information with their target genes. Finally, we show that knock-down of FRA1 and FLI1 result in significant reduction of invasion capacity of MIBC cells towards muscle microenvironment using IC-CHIP assays. Our results collectively highlight the role of these transcription factors in selection and design of targeted options for treatment of MIBC.
Copper-catalyzed alkyne oxidation/Büchner-type ring-expansion to access benzo[6,7]azepino[2,3-b]quinolines and pyridine-based diones
Authors: Jiang Xiao-Lei , Liu Qing , Wei Kua-Fei , Zhang Ting-Ting , Ma Guang , Zhu Xiu-Hong , Ru Guang-Xin , Liu Lijie , Hu Lian-Rui , Shen Wen-Bo
Published: February 2023

General access to highly valuable seven-membered rings via Büchner-type reaction remains a formidable challenge. Here we report a Cu-catalyzed intermolecular oxidation of alkynes using N-oxides as oxidants, which enables expedient preparation of valuable benzo[6,7]azepino[2,3-b]quinolines and pyridine-based diones. Importantly, in contrast to the well-established gold-catalyzed intermolecular alkyne oxidation, the dissociated pyridine or quinoline partner could be further utilized to construct N-heterocycles in this system and the reaction most likely proceeds by a Büchner-type ring expansion pathway. A mechanistic rationale for this cascade cyclization is supported by DFT calculations.
Above-ground tree carbon storage in response to nitrogen deposition in the U.S. is heterogeneous and may have weakened
Authors: Clark Christopher M. , Thomas R. Quinn , Horn Kevin J.
Published: February 2023

Changes in nitrogen (N) availability affect the ability for forest ecosystems to store carbon (C). Here we extend an analysis of the growth and survival of 94 tree species and 1.2 million trees, to estimate the incremental effects of N deposition on changes in aboveground C (dC/dN) across the contiguous U.S. (CONUS). We find that although the average effect of N deposition on aboveground C is positive for the CONUS (dC/dN = +9 kg C per kg N), there is wide variation among species and regions. Furthermore, in the Northeastern U.S. where we may compare responses from 2000-2016 with those from the 1980s–90s, we find the recent estimate of dC/dN is weaker than from the 1980s–90s due to  species-level changes in responses to N deposition. This suggests that the U.S. forest C-sink varies widely across forests and may be weakening overall, possibly necessitating more aggressive climate policies than originally thought.
Paper-based microfluidics in sweat detection: from design to application
Authors: Ye Zhichao , Yuan Yuyang , Zhan Shaowei , Liu Wei , Fang Lu , Li Tianyu
Published: February 2023

Paper-based microfluidics offers a promising way to in situ sweat detection for non-invasive continuous monitoring. This passage reviews and prospects its development regarding materials, structuring, fabrication, modular design and application.
Solvent effects of N,N-dimethylformamide and methanol on mass spectrometry imaging by tapping-mode scanning probe electrospray ionization
Authors: Otsuka Yoichi , Ote Nijiho , Sun Mengze , Shimma Shuichi , Urakawa Osamu , Yamaguchi Shinichi , Kudo Tomoya , Toyoda Michisato
Published: February 2023

Development of a mass spectrometry imaging system utilizing t-SPESI and its application to lipid imaging of tissue sections. The effects of solvent properties on the extraction-ionization process and the spatial resolution of ion images are discussed.
Sustainable preparation of aminosilane monomers, oligomers, and polymers through Si–N dehydrocoupling catalysis
Authors: Leland Brock E. , Mondal Joydeb , Trovitch Ryan J.
Published: February 2023

Aminosilanes have been broadly and sustainably prepared through the dehydrocoupling of amines and silanes with heterogeneous and homogeneous catalysts that span the periodic table.
Thermal transport across copper–water interfaces according to deep potential molecular dynamics
Authors: Li Zhiqiang , Tan Xiaoyu , Fu Zhiwei , Liu Linhua , Yang Jia-Yue
Published: February 2023

A deep learning potential distinct from the empirical potential is developed for the study of thermal transport across solid–liquid interfaces.
Robust electronic properties of monolayer BeO against molecule adsorption
Authors: Liu Hongsheng , Ksenevich Vitaly , Zhao Jijun , Gao Junfeng
Published: February 2023

BeO monolayers with and without Be vacancies show high structural and electronic stability upon exposure to air. O vacancies are not favorable and can be easily healed by H2O or CO2 adsorption.
Consequence of products from oxidative coupling of methane in a non-oxidative high temperature environment
Authors: Komada Haruka , Obata Keisuke , Li Duanxing , Sarathy S. Mani , Takanabe Kazuhiro
Published: February 2023

Oxidative coupling of methane (OCM) is an exothermic reaction that results in the temperature rise towards the latter part of the reactor. This study reports the consequence of OCM product distribution after O2depletion at high temperatures.
Machine learning for soft and liquid molecular materials
Authors: Orlova Tetiana , Piven Anastasiia , Darmoroz Darina , Aliev Timur , Tamer Abdel Razik Tamer Mahmoud , Boitsev Anton , Grafeeva Natalia , Skorb Ekaterina
Published: February 2023

This review discusses three types of soft matter and liquid molecular materials, namely hydrogels, liquid crystals and gas bubbles in liquids, which are explored with an emergent machine learning approach.
High-performance SiO electrodes for lithium-ion batteries: merged effects of a new polyacrylate binder and an electrode-maturation process
Authors: Yamazaki Shogo , Tatara Ryoichi , Mizuta Hironori , Kawano Kei , Yasuno Satoshi , Komaba Shinichi
Published: February 2023

SiO has been extensively studied as a high-capacity negative electrode material for lithium-ion batteries (LIBs).
Fluorescence excitation enhancement by waveguiding nanowires
Authors: Unksov Ivan N. , Anttu Nicklas , Verardo Damiano , Höök Fredrik , Prinz Christelle N. , Linke Heiner
Published: February 2023

Fluorescence excitation enhancement is important for biosensing; we for the first time study it quantitatively for GaP NWs.
Facile synthesis of crumpled nitrogen-doped porous carbon nanosheets with ultrahigh surface area for high-performance supercapacitors
Authors: Chen Chong , Shao Jiacan , Zhang Yaru , Sun Li , Zhang Keying , Wang Hongyan , Zhu Guang , Xie Xusheng
Published: February 2023

Ultrathin crumpled porous carbon nanosheets with ultrahigh surface area are fabricated by adenosine blowing and KOH activation strategy.
Dinuclear oxidovanadium complexes with dihydrazone ligands derived from diethyl 2,6-dimethylpyridine-3,5-dicarboxylate obtained from Hantzsch reaction; crystal structure and catalytic activity
Authors: Soltani Fatemeh , Bikas Rahman , Heydari Neda , Kozakiewicz-Piekarz Anna
Published: February 2023

Hantzsch pyridine ester has been used as a precursor for the synthesis of dihydrazone ligands. Two dinuclear V(v) complexes obtained by these ligands show high catalytic activity in the oxidation of sulfides.
A steep-switching impact ionization-based threshold switching field-effect transistor
Authors: Kang Chanwoo , Choi Haeju , Son Hyeonje , Kang Taeho , Lee Sang-Min , Lee Sungjoo
Published: February 2023

A steep switching transistor (subthreshold swing, SS ∼32.8 mV dec−1) with low dielectric injection efficiency (ΔIGS/ΔIDS ∼10−6 is constructed by connecting an MoS2 FET and a WSe2 impact-ionisation based threshold switch.
Hydroxyl–yne click polymerization: a facile strategy toward poly(vinyl amino ether ester)s with color-tunable luminescence
Authors: Jiang Qimin , Zhang Hongyan , Jiang Qilin , Zhang Shuyi , Guan Shuyi , Huang Wenyan , Xue Xiaoqiang , Yang Hongjun , Jiang Li , Jiang Bibiao , Komarneni Sridhar
Published: February 2023

This study established an environmentally friendly hydroxyl–yne click polymerization, which provides a new strategy for the preparation of color-tunable unconventional luminescent materials.
Progress of layered double hydroxide-based materials for supercapacitors
Authors: Li Xue , Ren Jianning , Sridhar Deepak , Xu Ben Bin , Algadi Hassan , El-Bahy Zeinhom M. , Ma Yong , Li Tingxi , Guo Zhanhu
Published: February 2023

The methods for the preparation and modification of layered double hydroxides (LDHs) in recent years are reviewed in this paper. In addition, their electrochemical properties and applications in the field of supercapacitors are demonstrated.
In situ Ti assisted graphitization approach for the preparation of graphite foam with light weight and high thermal conductivity
Authors: Guo Xing , Liu Yaxiong , Tian Xiaodong , Tao Zechao , Yan Xi , Liu Zhanjun
Published: February 2023

In this study, a lightweight and high thermal conductivity graphite foam with perfect crystal structure and superior graphitization degree was fabricated via in situ titanium assisted catalytic graphitization strategy.
AFM evaluation of a humanized recombinant antibody affecting C. auris cell wall and stability
Authors: Vanzolini Tania , Di Mambro Tomas , Magnani Mauro , Menotta Michele
Published: February 2023

AFM data about C. auris topography, surface biochemistry and nanomechanics are good indicators for the evaluation of the effects of the humanized monoclonal antibody H5K1 alone and in combination with commercially available antifungal drugs.
A multi-faceted approach to probe organic phase composition in TODGA systems with 1-alcohol phase modifiers
Authors: Peroutka Allison A. , Galley Shane S. , Shafer Jenifer C.
Published: February 2023

The effect of varying 1-alcohol alkyl chain length on extraction of lanthanides (Lns), H2O, and H+ was studied with tetraoctyl diglycolamide (TODGA) via solvent extraction coupled with FT-IR investigations.
Interpenetrating polymer networks for desalination and water remediation: a comprehensive review of research trends and prospects
Authors: Dutta Soumi , Gupta Ria Sen , Pathan Shabnam , Bose Suryasarathi
Published: February 2023

A comprehensive review of research trends and prospects for interpenetrating polymer networks (IPNs) for desalination and water remediation is presented in this article.
Preparation, characterization, and energy simulation of ZnTiO3 high near-infrared reflection pigment and its anti-graffiti coating
Authors: Wang Song , Wang Jihu , Wen Shaoguo , Li Hui , Xie Chen , Li Shuaibiao , Mei Dajiang
Published: February 2023

ZnTiO3 (ZT) is a new cooling materials. This image is the synthesis process of nano ZnTiO3 and modified by stearic acid.
Tunable hydrogen evolution activity by modulating polarization states of ferroelectric BaTiO3
Authors: Qiu Haifa , Yang Tong , Zhou Jun , Yang Ke , Ying Yiran , Ding Keda , Yang Ming , Huang Haitao
Published: February 2023

We computationally reveal that HER activity on BTO is governed by polarization states, being optimal with in-plane polarization. A strain driven HER cycle on BTO between downward and in-plane polarization is proposed to overcome the Sabatier limit.
Theoretical study on the reduction mechanism of CO2 to HCOOH on Pd3Au: an explicit solvent model is essential
Authors: Zheng Ming , Zhou Xin , Wang Yixin , Chen Gang , Li Mingxia
Published: February 2023

The work function and d-band center of a catalyst together determine the catalytic activity of CO2 reduction to formic acid. And it is necessary to consider the solvation effect using an explicit solvent model.
Discovery of thermosetting polymers with low hygroscopicity, low thermal expansivity, and high modulus by machine learning
Authors: Xu Xinyao , Zhao Wenlin , Hu Yaxi , Wang Liquan , Lin Jiaping , Qi Huimin , Du Lei
Published: February 2023

Based on the workflow of the materials genome approach, the challenge of enhancing multiple conflicting properties of an advanced thermosetting polymer of polycyanurates was addressed through high-throughout screening using machine learning.
Synthesis, properties and catalytic performance of the novel, pseudo-spinel, multicomponent transition-metal selenides
Authors: Mikuła Andrzej , Dąbrowa Juliusz , Kubowicz Maciej , Cieślak Jakub , Lach Wiktor , Kożusznik Miłosz , Smialkowski Mathias , Apfel Ulf-Peter
Published: February 2023

With electrocatalysis being the very foundation of multiple energy conversion technologies, the search for more effective, and affordable catalysts is becoming increasingly important for their further development.
High-throughput screening of hybrid quaternary halide perovskites for optoelectronics
Authors: Yang Kesong , Li Yuheng , Zhang Jingning
Published: February 2023

This work demonstrates a high-throughput computational screening of novel hybrid quaternary halide perovskites for photovoltaic and light-emitting applications.
Interpenetrating network design of bioactive hydrogel coatings with enhanced damage resistance
Authors: Wancura Megan , Nkansah Abbey , Chwatko Malgorzata , Robinson Andrew , Fairley Ashauntee , Cosgriff-Hernandez Elizabeth
Published: February 2023

An interpenetrating network design was used to enhance the toughness of PEG-based hydrogel coatings to resist damage during surgical handling.
An insight into the temperature dependence of photoluminescence of a highly-emissive Cs-Ag(Na)Bi(In)Cl6 perovskite
Authors: Stroyuk Oleksandr , Raievska Oleksandra , Osvet Andres , Hauch Jens , Brabec Christoph J.
Published: February 2023

The temperature-dependent evolution of the photoluminescence (PL) properties of a highly emissive Cs2Ag0.35Na0.65Bi0.02In0.98Cl6 perovskite was examined in the range of 80–340 K.
Lanthanide ion doping enabling highly sensitive and stable all-inorganic CsPbI2Br perovskite photodetectors
Authors: Fang Zhiyuan , Ding Nan , Xu Wen , Wang Tianyuan , Wang Yue , Zi Lu , Hu Junhua , Lu Siyu , Zhou Donglei , Bai Xue , Song Hongwei
Published: February 2023

We introduce Ln3+ ions into all-inorganic CsPbI2Br films. Photodetectors based on CsPbI2Br:Yb3+ films achieve a D* of 4.6 × 1012 Jones, a detection range of 300–700 nm, quick response time (640 ns) and good stability.
Development of GTP-responsive liposomes by exchanging the metal-DPA binding site in a synthetic lipid switch
Authors: Lou Jinchao , Hudson Macy M. , Ancajas Christelle F. , Best Michael D.
Published: February 2023

We report stimuli-responsive liposomes that selectively release encapsulated contents upon treatment with guanosine triphosphate (GTP) over a wide variety of phosphorylated metabolites, validated by fluorescence-based leakage assays.
Infrared spectra of isoquinolinium (iso-C9H7NH+) and isoquinolinyl radicals (iso-C9H7NH and 1-, 3-, 4-, 5-, 6-, 7- and 8-iso-HC9H7N) isolated in solid para-hydrogen
Authors: Joshi Prasad Ramesh , Tsuge Masashi , Tseng Chih-Yu , Lee Yuan-Pern
Published: February 2023

The protonation of isoquinoline was observed at the N-atom site, whereas the hydrogenation of isoquinoline was observed at the N-atom site and at all C-atom sites except for the sharing C atoms on the fused ring.
Construction and arm evolution of trifunctional phenolic initiator-mediated polycarbonate polyols produced by using a double metal cyanide catalyst
Authors: Zhang Xiao , Dong Jincheng , Su Yun , Lee Eun Gyeong , Duan Zhongyu , Kim Il , Liu Binyuan
Published: February 2023

The evolution of the number and length of the tri-arm oligo(carbonate-ether) triols synthesized by CO2/propylene oxide copolymerization using a Zn/Co double metal cyanide catalyst are elucidated.
Sequential dual-curing of electron-deficient olefins and alcohols relying on oxa-Michael addition and anionic polymerization
Authors: Fischer Susanne M. , Schallert Viktor , Uher Johanna M. , Slugovc Christian
Published: February 2023

Polymer networks were obtained by anionic copolymerization of diacrylates and sub-stoichiometric amounts of diols using Lewis base catalysis.
Dramatically improved optical anisotropy by realizing stereochemically active lone pairs in a sulfate system, K2SO4·HIO3
Authors: Bai Zhiyong , Ok Kang Min
Published: February 2023

A novel birefringent material, K2SO4·HIO3, was developed by introducing a polyhedron of lone pair cations. This material shows a 70-fold increase in birefringence compared to the corresponding monosulfate, K2SO4.
TiO2/graphitic carbon nitride nanosheet composite with enhanced sensitivity to atmospheric water
Authors: Maluangnont Tosapol , Pulphol Phieraya , Pongampai Satana , Kobkeatthawin Thawanrat , Smith Siwaporn Meejoo , Vittayakorn Naratip
Published: February 2023

The TiO2/CNNS composite shows enhanced sensitivity to atmospheric water (i.e., varied impedance with exposure to air during the measurement) compared to CNNS.
Complexes of Ag and ZnO nanoparticles with BBR for enhancement of gastrointestinal antibacterial activity through the impacts of size and composition
Authors: Nguyen Hue Thi , Pham Tuyet Nhung , Le Le Thi , Nguyen Tien Khi , Le Anh-Tuan , Huy Tran Quang , Thu Nguyen Thuy Thi
Published: February 2023

The presence of BBR resulted in the formation of small core/shell structured Ag/BBR and ZnO/BBR nanoparticles and improvement of antibacterial activity.
Feruloylmonotropeins: promising natural antioxidants in Paederia scandens
Authors: Trung Nguyen Quang , Thu Thanh Nguyen Thi , Hoa Nguyen Thi , Mechler Adam , Vo Quan V.
Published: February 2023

Feruloylmonotropeins (FMTs), derived from Paederia scandens, are expected to be potent radical scavengers in physiological aqueous environments.
Nano–bio interaction between human immunoglobulin G and nontoxic, near-infrared emitting water-borne silicon quantum dot micelles
Authors: Chinnathambi Shanmugavel , Shirahata Naoto , Kumar Mahima , Karthikeyan Subramani , Abe Katsuhiko , Thangavel Vaijayanthi , Pandian Ganesh N.
Published: February 2023

We prepared Pluronic-F127 coated silicon quantum dot micelles and examined their interaction with Human IgG. Furthermore, the micelles were used to image cells as well as medaka (Oryzias latipes) eggs and larvae without causing cytotoxicity.
Spirocitrinols A and B, citrinin derivatives with a spiro[chromane-2,3′-isochromane] skeleton from Penicillium citrinum
Authors: Tong Junjie , Zhang Yang , Xu Yang , Han Yangyang , Li Chuan , Zhuang Wenying , Che Yongsheng
Published: February 2023

Two new citrinin-derived metabolites spirocitrinols A (1) and B (2) with a spiro[chromane-2,3′-isochromane] skeleton were isolated from cultures of Penicillium citrinum. Compound 1 showed moderate cytotoxicity towards human tumor cells.
Reaching the 5% theoretical limit of fluorescent OLEDs with push–pull benzophospholes
Authors: Ledos Nicolas , Tondelier Denis , Geffroy Bernard , Jacquemin Denis , Bouit Pierre-Antoine , Hissler Muriel
Published: February 2023

Push–pull benzophospholes were synthesized and characterized. They could reach the 5% theoretical limit of external quantum efficiency of fluorescent OLEDs.
Steam computing paradigm: Cross‐layer solutions over cloud, fog, and edge computing
Authors: Mchergui Abir , Hajlaoui Rejab , Moulahi Tarek , Alabdulatif Abdulatif , Lorenz Pascal
Published: February 2023

Conventional infrastructures based on the cloud are not sufficient for the emerging Internet of Things (IoT) applications requirements. Many big problems are shortcomings, especially in terms of network bandwidth and latency. Throughout recent years, the idea to relieve fog computing and edge computing was suggested by bringing data processing capacities closer to these limits to the edge of the network. The authors assume that the full potential of IoT will, in many cases, only be activated by the combination of cloud, fog, and edge computing in a new computing paradigm, given IoT growth and development forecasts. This article discusses the possibility and need for such a paradigm by introducing steam computing as a new distributed type of computing using cloud, fog, and edge utilities to carry out data processing and storage. The authors treat steam computing through four planes: security and privacy plane, data analytics and fault tolerance plane and deployment and test beds plane. Finally, the authors focus on the open issues and future trends in steam computing.
Regards sur le paysage
Authors: Chapuis Élisabeth
Published: February 2023

L’expérience esthétique du paysage est historiquement construite. Les premières représentations de paysages apparues à la Renaissance ont permis la naissance d’un genre pictural grâce à l’invention de la perspective qui a fourni une technique de représentation de l’espace mais traduirait une volonté d’emprise de l’homme sur la nature dont les manifestations déréglées aboutissent au désastre écologique actuel.

Du côté du promeneur ou du spectateur, peut-on renouer avec un plaisir du paysage prenant en compte d’autres points de vue qui ouvriraient à un espace imaginaire de rêverie et de subjectivité créatrice capable de contrer le pessimisme contemporain ?
Le paysage et les questions qu’il pose à la représentation
Authors: Thibierge Stéphane
Published: February 2023

Cet article interroge le concept de paysage et en quoi ce concept questionne les éléments de notre représentation. Il montre comment le paysage renvoie d’abord à la reconnaissance d’une forme par un sujet, mais aussi au-delà, et de façon plus complexe, à la dimension du réel et à celle de l’objet telles que la psychanalyse les articule. Le refoulement de ce réel est ce qui produit dans le paysage des éléments non reconnaissables mais plutôt déchiffrables, comme des lettres qui appellent une lecture. En d’autres termes les éléments du paysage et sa structure ne concernent pas seulement l’imaginaire, mais sont aussi de l’ordre du réel et du symbolique. Pour montrer cela, l’article s’appuie sur la théorie et la pratique de l’expérience psychanalytique, et sur ce qu’elle nous permet d’établir.

Il évoque aussi quelques exemples en peinture et en photographie pouvant illustrer les points ici discutés. Enfin il aborde, en relation avec le paysage, les notions respectivement du nu et du visage.
Therapeut*innen: „Rechte Hand“ des Opfers gegen Täter*innen?
Authors: Bossenmayer Jörg
Published: February 2023

Therapeut*innen wollen und sollen Patient*innen helfen. Manchmal aber ist es gar nicht so einfach zu erkennen, wo die Grenze zwischen Helfen und Schaden verläuft. Dies gilt insbesondere dann, wenn Patient*innen Opfer von Straftaten geworden sind und den Therapeut*innen davon in der Therapie berichten.
Krebs und Partnerschaft – Ansatzpunkte therapeutischer Interventionen
Authors: Weißflog Gregor , Ernst Jochen
Published: February 2023

Eine Krebserkrankung wirkt sich in vielfacher Weise auf die Partnerschaft aus und kann zu vielfältigen Belastungen bei Patient*innen und deren Partner*innen führen. Dieser Beitrag informiert über psychoonkologische Interventionsansätze zur Reduktion dieser Belastungen in Partnerschaften. Dabei werden stressorenbezogene sowie anpassungsprozessbezogene Herangehensweisen diskutiert und mit konkreter therapeutischer Methodik verknüpft.
Was Psychotherapeut*innen wissen müssen: Neue Therapiemethoden in der Onkologie
Authors: Augustin Marinela
Published: February 2023

Das Wissen im Bereich der Hämatologie und Onkologie hat in den vergangenen Jahren eine beeindruckende Entwicklung erfahren – sowohl zu den Grundlagen der Tumorbiologie als auch zu Diagnostik und Therapie. Dieser komprimierte Überblick über medizinische Behandlungsansätze soll psychotherapeutisch Tätigen helfen, sich in der Komplexität der medizinischen Krebsbehandlung zu orientieren.
Sterbehilfe in der Onkologie – rechtlich-ethischer Rahmen
Authors: Erbguth Frank
Published: February 2023

Bei jedem fünften Krebspatienten kommen Todeswünsche zur Sprache, die auch das Thema „Sterbehilfe“ beinhalten können. Dieser Begriff ist jedoch unscharf und steht für ein ganzes Spektrum von rechtlich verbotenen oder erlaubten Handlungsoptionen beim oder zum Sterben. Für die Begleitung der Erkrankten ist es daher wichtig, den juristischen und ethischen Kontext der sog. „Sterbehilfe“ zu kennen.
Imagination und Hypnose in der Psychoonkologie
Authors: Krauß Leonie , Hönig Klaus
Published: February 2023

Die Arbeit mit Imagination bietet sich in der psychoonkologischen Versorgung in besonderer Weise an, da sie den oft schwerkranken Menschen eine kräfteschonende Bearbeitung körperlicher, geistiger und emotionaler Probleme auf einer inneren Bühne ermöglicht. Ein hypnotisch vertieftes ressourcenorientiertes Vorgehen bringt dabei die erwünschten Veränderungsprozesse im Verhalten und Erleben oft rascher und nachhaltiger in Gang.
Psychoonkologie – Informationen und Hilfe für Betroffene und Expert*innen
Authors: Hochradel Lea
Published: February 2023

Aufklärung, Behandlung und Prävention von psychischen Belastungen im Rahmen einer Krebserkrankung sind Bestandteile der psychoonkologischen Forschung und Praxis. Im Internet können sich Experten, Interessierte, Betroffene und Angehörige umfangreich informieren. Das Angebot umfasst dabei Wissensvermittlung, praktische Tipps für den Alltag, Kontakte zu Beratungsstellen sowie die Möglichkeit zu Vernetzung und Austausch unter Fachkreisen und Betroffenen.
Die Angst der Psychotherapeut*innen vor dem Tod
Authors: Vogel Ralf T.
Published: February 2023

Die Arbeit mit schwer körperlich kranken Menschen bedeutet für jede*n Psychotherapeut*in eine unumgängliche Konfrontation mit eigenen, oft verborgenen Ängsten bzgl. der körperlichen Unversehrtheit und der eigenen Sterblichkeit. Das nicht zu verleugnen, sondern sich diesen Emotionen zu stellen und sie als Teil der therapeutischen Arbeit anzuerkennen, gehört zu den Grundkompetenzen psychotherapeutischen Handelns im Umfeld des Todes.
Familie im Fokus: Systemisch-lösungsfokussierte Begleitung in der pädiatrischen Onkologie
Authors: Schepper Florian , Herrmann Jessy , Vogt Manfred
Published: February 2023

Ein Kind ist niemals alleine krank – daher muss die psychosoziale Begleitung in der pädiatrischen Onkologie das System Familie in besonderer Weise einbeziehen. In diesem Beitrag stellen wir ein aus der Versorgungspraxis entwickeltes therapeutisches Arbeitsmodell vor.
Cannabis – eine politisierte Arzneidroge
Authors: Melzig Matthias F.
Published: February 2023

Seit mehr als 2000 Jahren gehört Cannabis zur Materia medica der
europäischen Heilkunde. Dioskurides beschreibt die therapeutische Anwendung
bei Ohrenleiden. Gleichzeitig warnt er vor dem übermäßigen
Gebrauch der Früchte, da sie „die Zeugung vernichten“.
Eigentlich eine völlig unspektakuläre Droge, wenn nicht die
blühenden, getrockneten Triebspitzen der weiblichen Pflanzen spezieller
Züchtungen so eine starke psychotrope Wirkung hätten, die seit dem
Altertum zu Rausch- und Genusszwecken genutzt wurden. Unter der Bezeichnung
Haschisch ist das extrahierte Harz in Deutschland, als auch weltweit, die am
häufigsten illegal konsumierte Droge.
Die Cannabisagentur am Bundesinstitut für Arzneimittel und
Medizinprodukte
Authors: Ledderhose Cindy , Otting Henrike , Wolf Anne , Knöss Werner
Published: February 2023

Im Jahre 2017 legte das sogenannte „Cannabisgesetz“ die Grundlage
für die Errichtung der Cannabisagentur am Bundesinstitut für
Arzneimittel und Medizinprodukte (BfArM). Die Aufgaben der Cannabisagentur
umfassen die Kontrolle und Steuerung des Anbaus und der Herstellung von Cannabis
für medizinische Zwecke in Deutschland. Nach den Regelungen des
Einheitsübereinkommens über Suchtstoffe der Vereinten Nationen
von 1961 nimmt die Cannabisagentur die Cannabisblüten mit der Ernte in
Besitz. Daher ist die Cannabisagentur Inverkehrbringer der
Cannabisblüten als Arzneimittel und agiert als Pharmazeutischer
Unternehmer und Großhändler. Inzwischen sind medizinische
Cannabisblüten, die nach der aktuellen Rechtslage
Betäubungsmittel sind, aus dem Anbau in Deutschland verfügbar
und können von Apotheken bei Vorlage einer individuellen Verschreibung
als Rezepturarzneimittel an Patientinnen und Patienten abgegeben werden.
Für Cannabisblüten als pflanzliches Arzneimittel gelten die
gleichen Ansprüche an eine reproduzierbare pharmazeutische
Qualität wie für andere pflanzliche Arzneimittel.
Pitfalls in Coagulation Testing
Authors: Sachs Ulrich J.
Published: February 2023

Assays in the coagulation laboratory are affected by numerous variables. Variables which have impact on the test result can lead to incorrect results, and potentially to consequences for further diagnostic and therapeutic decisions made by the clinician. The interferences can be separated into three main groups: biological interferences, with an actual impairment of the patient's coagulation system (congenital or acquired); physical interferences, which usually occur in the pre-analytical phase; and chemical interferences, because of the presence of drugs (mainly anticoagulants) in the blood to be tested. This article discusses some of these interferences in seven instructive cases of (near) miss events as an approach to generate more attention to these issues.
Evidence-Based Medicine: Principles and Values as Illustrated by the Case of Patient Blood Management
Authors: Van Remoortel Hans , De Buck Emmy , Seifried Erhard , Vandekerckhove Philippe
Published: February 2023

Evidence-based medicine is considered 1 of the 15 great inventions in medicine. It aims to remove bias in medical decision-making as much as possible through a rigorous process. In this article, the principles of evidence-based medicine are illustrated using the case of patient blood management (PBM). Acute or chronic bleeding, iron deficiency, and renal and oncological diseases may lead to preoperative anemia. To compensate for severe and life-threatening blood loss during surgery, doctors transfuse red blood cells (RBCs). PBM is an approach to take care of patients at risk for anemia, which includes detecting and treating anemia before surgery. Alternative interventions to treat preoperative anemia are the use of iron supplementation with or without erythro-stimulating agents (ESAs). The best available scientific evidence today indicates that preoperative intravenous (IV) or oral iron monotherapy may not be effective to reduce RBC utilization (low-certainty evidence). Preoperative IV iron supplementation in addition to ESAs is probably effective to reduce RBC utilization (moderate-certainty evidence), whereas oral iron supplementation in addition to ESAs may be effective to reduce RBC utilization (low-certainty evidence). The adverse events of preoperative oral/IV iron and/or ESAs and their impact on patient-important outcomes (morbidity, mortality, quality of life) remain unclear (very low-certainty evidence). Since PBM is a patient-centered approach, emphasis on monitoring and evaluation of patient-important outcomes in future research is urgently needed. Finally, the cost-effectiveness of preoperative oral/IV iron monotherapy is unproven, whereas preoperative oral/IV iron in addition to ESAs is extremely cost-ineffective.
Kneipp-Medizin bei Schlafstörungen
Authors: Schuh Angela
Published: February 2023

Hauptursache der nicht organischen Schlafstörung stellt der eigene Lebensstil dar. Deshalb muss die Lebensstiländerung oder -modifikation die erste und wichtigste Maßnahme darstellen, um eine Verbesserung der Schlafsituation zu erreichen. Spezifische Behandlungsansätze bestehen aus kognitiv-verhaltenstherapeutischen Gruppenprogrammen. Aber auch körperliche Aktivität und die Ausübung gemäßigter Sportarten haben ihre schlaffördernde Wirkung belegt. Daneben ist die Kneipp-Therapie ein seit langem anerkanntes Verfahren bei Schlafstörungen. Bei nicht organischen Ein- und Durchschlafstörungen kann jedes Element der Kneipp-Therapie einen eigenständigen Beitrag zur Schlafförderung leisten. Eine begleitende Studie der LMU München („Gesunder Schlaf durch innere Ordnung“) untersuchte bei Menschen mit nicht organischen, lebensstilbedingten Schlafstörungen die kurz- und mittelfristigen Effekte eines 3-wöchigen Kneipp-Kur-Präventionsprogramms im Vergleich zu einer Kontrollgruppe und konnte deutliche und anhaltende Verbesserungen zeigen.
Update Motorisches Lernen (2) Das Lernrad
Authors: Huber Martin
Published: February 2023

Vertiefen Sie sich in das Lernrad. Es visualisiert geradezu in idealer Weise, was Sie zum motorischen Lernen wissen müssen und unterstützt die Umsetzung in die Praxis.
47.1.1.4.12 Synthesis of Alkenes by Palladium-Catalyzed Cross-Coupling Reactions with Carbene Precursors
Authors: Wang K. , Wang J.
Published: February 2023

This review describes the synthesis of multisubstituted alkenes through palladium-catalyzed cross-coupling reactions with carbene precursors. In the past decade, transition-metal-catalyzed cross couplings involving carbenes have witnessed remarkable development, including those that form alkenes as the products. These palladium-catalyzed coupling reactions are summarized here, according to the type of cross-coupling partners and the carbene precursors.
Educational and accessible museums and cultural spaces
Authors: González-Herrera Ana Isabel , Díaz-Herrera Andrea Betsabé , Hernández-Dionis Paula , Pérez-Jorge David
Published: February 2023

Offering access to culture and education to all citizens is a challenge nowadays, inclusive and accessible spaces are increasingly necessary if we really want to offer equal opportunities to all people regardless of their condition, physical or health. This systematic review study aims to investigate the situation of accessibility in museums and other cultural spaces as alternative learning spaces. It analyzes the historical evolution of cultural spaces as learning spaces and analyzes the reality of these spaces in terms of their accessibility conditions. For this purpose, an exhaustive search of documents was carried out between 2015 and 2021, following the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) statement, from the Web of Science (WOS), Scopus and Dialnet databases. After the analysis and application of selection criteria, a total of 17 documents were found that show the transformation of these cultural spaces, the improvement of their accessibility and adaptation to the new times. The need to offer cultural spaces for all is a challenge that must be consolidated as a social value.