bluuebunny/crossref_metadata_2025 huggingface dataset:
Methyl jasmonate induction of tanshinone biosynthesis in Salvia miltiorrhiza hairy roots is mediated by JASMONATE ZIM-DOMAIN repressor proteins
Authors: Shi Min , Zhou Wei , Zhang Jianlin , Huang Shengxiong , Wang Huizhong , Kai Guoyin
Published: February 2016

Jasmonic acid (JA) is an important plant hormone involved in regulation of many aspects of plant growth and development including secondary metabolism and JASMONATE ZIM-DOMAIN (JAZ) proteins are key components in JA signal processes. In this study, two new JAZ genes named SmJAZ3 and SmJAZ9 were cloned from S. miltiorrhiza hairy roots and characterized. Expression profiles under methyl jasmonate (MJ) treatment revealed that SmJAZ3 and SmJAZ9 were both MJ-responsive. Subcellular localization assay showed that SmJAZ3 was located in nucleus while SmJAZ9 was preferentially in nucleus. Expression of SmJAZ3 and SmJAZ9 in S. miltiorrhiza hairy roots differently affected the production of tanshinone. Over-expression of SmJAZ3 or SmJAZ9 in hairy roots produced lower level of tanshinone compared with the control, tanshinone production was as low as 0.077 mg/g DW in line SmJAZ3-3 and 0.266 mg/g DW in line SmJAZ9-22. Whereas, down-regulation of SmJAZs enhanced tanshione production, the content of tanshinone increased to 2.48 fold in anti-SmJAZ3-3 line and 1.35-fold in anti-SmJAZ9-23 line. Our work indicated that SmJAZ3 and SmJAZ9 are involved in regulation of tanshinone biosynthesis and act as repressive transcriptional regulators in the JA signaling pathway, which paves the way to further dissect molecular mechanism in details in the future.
Representation of economic preferences in the structure and function of the amygdala and prefrontal cortex
Authors: Fermin Alan S. R. , Sakagami Masamichi , Kiyonari Toko , Li Yang , Matsumoto Yoshie , Yamagishi Toshio
Published: February 2016

Social value orientations (SVOs) are economic preferences for the distribution of resources – prosocial individuals are more cooperative and egalitarian than are proselfs. Despite the social and economic implications of SVOs, no systematic studies have examined their neural correlates. We investigated the amygdala and dorsolateral prefrontal cortex (DLPFC) structures and functions in prosocials and proselfs by functional magnetic resonance imaging and evaluated cooperative behavior in the Prisoner’s Dilemma game. We found for the first time that amygdala volume was larger in prosocials and positively correlated with cooperation, while DLPFC volume was larger in proselfs and negatively correlated with cooperation. Proselfs’ decisions were marked by strong DLPFC and weak amygdala activity and prosocials’ decisions were marked by strong amygdala activity, with the DLPFC signal increasing only in defection. Our findings suggest that proselfs’ decisions are controlled by DLPFC-mediated deliberative processes, while prosocials’ decisions are initially guided by automatic amygdala processes.
Efficacy of covered and bare stent in TIPS for cirrhotic portal hypertension: A single-center randomized trial
Authors: Wang Lei , Xiao Zhibo , Yue Zhendong , Zhao Hongwei , Fan Zhenhua , Zhao Mengfei , He Fuliang , Dai Shan , Qiu Bin , Yao Jiannan , Lin Qiushi , Dong Xiaoqun , Liu Fuquan
Published: February 2016

We conducted a single-center randomized trial to compare the efficacy of 8 mm Fluency covered stent and bare stent in transjugular intrahepatic portosystemic shunt (TIPS) for cirrhotic portal hypertension. From January 2006 to December 2010, the covered (experimental group) or bare stent (control group) was used in 131 and 127 patients, respectively. The recurrence rates of gastrointestinal bleeding (18.3% vs. 33.9%, P = 0.004) and refractory hydrothorax/ascites (6.9% vs. 16.5%, P = 0.019) in the experimental group were significantly lower than those in the control group. The cumulative restenosis rates in 1, 2, 3, 4 and 5-years in the experimental group (6.9%, 11.5%, 19.1%, 26.0% and 35.9%, respectively) were significantly lower (P < 0.001) than those in the control group (27.6%, 37.0%, 49.6%, 59.8%, 74.8%, respectively). Importantly, the 4 and 5-year survival rates in the experimental group (83.2% and 76.3%, respectively) were significantly higher (P = 0.001 and 0.02) than those in the control group (71.7% and 62.2%, respectively). The rate of secondary interventional therapy in the experimental group was significantly lower than that in the control group (20.6% vs. 49.6%; P < 0.001). Therefore, Fluency covered stent has advantages over the bare stent in terms of reducing the restenosis, recurrence and secondary interventional therapy, whereas improving the long-term survival for post-TIPS patients.
Broadband coherent Raman spectroscopy running at 24,000 spectra per second
Authors: Hashimoto Kazuki , Takahashi Megumi , Ideguchi Takuro , Goda Keisuke
Published: February 2016

We present a Fourier-transform coherent anti-Stokes Raman scattering (FT-CARS) spectroscopy technique that achieves broadband CARS measurements at an ultrahigh scan rate of more than 20,000 spectra/s – more than 20 times higher than that of previous broadband coherent Raman scattering spectroscopy techniques. This is made possible by an integration of a FT-CARS system and a rapid-scanning retro-reflective optical path length scanner. To demonstrate the technique’s strength, we use it to perform broadband CARS spectroscopy of the transient mixing dynamics of toluene and benzene in the fingerprint region (200–1500 cm−1) with spectral resolution of 10 cm−1 at a record high scan rate of 24,000 spectra/s. Our rapid-scanning FT-CARS technique holds great promise for studying chemical dynamics and wide-field label-free biomedical imaging.
Comprehensive profiling of lysine acetylproteome analysis reveals diverse functions of lysine acetylation in common wheat
Authors: Zhang Yumei , Song Limin , Liang Wenxing , Mu Ping , Wang Shu , Lin Qi
Published: February 2016

Lysine acetylation of proteins, a dynamic and reversible post-translational modification, plays a critical regulatory role in both eukaryotes and prokaryotes. Several researches have been carried out on acetylproteome in plants. However, until now, there have been no data on common wheat, the major cereal crop in the world. In this study, we performed a global acetylproteome analysis of common wheat variety (Triticum aestivum L.), Chinese Spring. In total, 416 lysine modification sites were identified on 277 proteins, which are involved in a wide variety of biological processes. Consistent with previous studies, a large proportion of the acetylated proteins are involved in metabolic process. Interestingly, according to the functional enrichment analysis, 26 acetylated proteins are involved in photosynthesis and Calvin cycle, suggesting an important role of lysine acetylation in these processes. Moreover, protein interaction network analysis reveals that diverse interactions are modulated by protein acetylation. These data represent the first report of acetylome in common wheat and serve as an important resource for exploring the physiological role of lysine acetylation in this organism and likely in all plants.
Optimization of a nanotechnology based antimicrobial platform for food safety applications using Engineered Water Nanostructures (EWNS)
Authors: Pyrgiotakis Georgios , Vedantam Pallavi , Cirenza Caroline , McDevitt James , Eleftheriadou Mary , Leonard Stephen S. , Demokritou Philip
Published: February 2016

A chemical free, nanotechnology-based, antimicrobial platform using Engineered Water Nanostructures (EWNS) was recently developed. EWNS have high surface charge, are loaded with reactive oxygen species (ROS) and can interact-with and inactivate an array of microorganisms, including foodborne pathogens. Here, it was demonstrated that their properties during synthesis can be fine tuned and optimized to further enhance their antimicrobial potential. A lab based EWNS platform was developed to enable fine-tuning of EWNS properties by modifying synthesis parameters. Characterization of EWNS properties (charge, size and ROS content) was performed using state-of-the art analytical methods. Further their microbial inactivation potential was evaluated with food related microorganisms such as Escherichia coli, Salmonella enterica, Listeria innocua, Mycobacterium parafortuitum and Saccharomyces cerevisiae inoculated onto the surface of organic grape tomatoes. The results presented here indicate that EWNS properties can be fine-tuned during synthesis resulting in a multifold increase of the inactivation efficacy. More specifically, the surface charge quadrupled and the ROS content increased. Microbial removal rates were microorganism dependent and ranged between 1.0 to 3.8 logs after 45 mins of exposure to an EWNS aerosol dose of 40,000 #/cm3.
Correlation between microbiota and growth in Mangrove Killifish (Kryptolebias marmoratus) and Atlantic cod (Gadus morhua)
Authors: Forberg Torunn , Sjulstad Eli Bjørnø , Bakke Ingrid , Olsen Yngvar , Hagiwara Atsushi , Sakakura Yoshitaka , Vadstein Olav
Published: February 2016

The vertebrate gut is host to large communities of bacteria, and one of the beneficial contributions of this commensal gut microbiota is the increased nutritional gain from feed components that the host cannot degrade on its own. Fish larvae of similar age and under the same rearing conditions often diverge with regards to growth. The underlying reasons for this could be differences in genetic background, feeding behavior or digestive capacity. Both feeding behavior and digestion can be influenced by differences in the microbiota. To investigate possible correlations between the size of fish larvae and their gut microbiota, we analyzed the microbiota small and large genetically homogenous killifish and genetically heterogeneous cod larvae by Bray-Curtis Similarity measures of 16S DNA DGGE patterns. A significant difference in richness (p = 0.037) was observed in the gut microbiota of small and large killifish, but the overall gut microbiota was not found to be significantly different (p = 0.13), indicating strong genetic host selection on microbiota composition at the time of sampling. The microbiota of small and large cod larvae was significantly different with regards to evenness and diversity (p = 0.0001), and a strong correlation between microbiota and growth was observed.
A nomogram to predict the probability of axillary lymph node metastasis in early breast cancer patients with positive axillary ultrasound
Authors: Qiu Si-Qi , Zeng Huan-Cheng , Zhang Fan , Chen Cong , Huang Wen-He , Pleijhuis Rick G. , Wu Jun-Dong , van Dam Gooitzen M. , Zhang Guo-Jun
Published: February 2016

Among patients with a preoperative positive axillary ultrasound, around 40% of them are pathologically proved to be free from axillary lymph node (ALN) metastasis. We aimed to develop and validate a model to predict the probability of ALN metastasis as a preoperative tool to support clinical decision-making. Clinicopathological features of 322 early breast cancer patients with positive axillary ultrasound findings were analyzed. Multivariate logistic regression analysis was performed to identify independent predictors of ALN metastasis. A model was created from the logistic regression analysis, comprising lymph node transverse diameter, cortex thickness, hilum status, clinical tumour size, histological grade and estrogen receptor and it was subsequently validated in another 234 patients. Coefficient of determination (R2) and the area under the ROC curve (AUC) were calculated to be 0.9375 and 0.864, showing good calibration and discrimination of the model, respectively. The false-negative rates of the model were 0% and 5.3% for the predicted probability cut-off points of 7.1% and 13.8%, respectively. This means that omission of axillary surgery may be safe for patients with a predictive probability of less than 13.8%. After further validation in clinical practice, this model may support increasingly limited surgical approaches to the axilla in breast cancer.
Frequency conversion of structured light
Authors: Steinlechner Fabian , Hermosa Nathaniel , Pruneri Valerio , Torres Juan P.
Published: February 2016

Coherent frequency conversion of structured light, i.e. the ability to manipulate the carrier frequency of a wave front without distorting its spatial phase and intensity profile, provides the opportunity for numerous novel applications in photonic technology and fundamental science. In particular, frequency conversion of spatial modes carrying orbital angular momentum can be exploited in sub-wavelength resolution nano-optics and coherent imaging at a wavelength different from that used to illuminate an object. Moreover, coherent frequency conversion will be crucial for interfacing information stored in the high-dimensional spatial structure of single and entangled photons with various constituents of quantum networks. In this work, we demonstrate frequency conversion of structured light from the near infrared (803 nm) to the visible (527 nm). The conversion scheme is based on sum-frequency generation in a periodically poled lithium niobate crystal pumped with a 1540-nm Gaussian beam. We observe frequency-converted fields that exhibit a high degree of similarity with the input field and verify the coherence of the frequency-conversion process via mode projection measurements with a phase mask and a single-mode fiber. Our results demonstrate the suitability of exploiting the technique for applications in quantum information processing and coherent imaging.
Pyruvate Kinase M2 Activates mTORC1 by Phosphorylating AKT1S1
Authors: He Chang-Liang , Bian Yang-Yang , Xue Yu , Liu Ze-Xian , Zhou Kai-Qiang , Yao Cui-Fang , Lin Yan , Zou Han-Fa , Luo Fang-Xiu , Qu Yuan-Yuan , Zhao Jian-Yuan , Ye Ming-Liang , Zhao Shi-Min , Xu Wei
Published: February 2016

In cancer cells, the mammalian target of rapamycin complex 1 (mTORC1) that requires hormonal and nutrient signals for its activation, is constitutively activated. We found that overexpression of pyruvate kinase M2 (PKM2) activates mTORC1 signaling through phosphorylating mTORC1 inhibitor AKT1 substrate 1 (AKT1S1). An unbiased quantitative phosphoproteomic survey identified 974 PKM2 substrates, including serine202 and serine203 (S202/203) of AKT1S1, in the proteome of renal cell carcinoma (RCC). Phosphorylation of S202/203 of AKT1S1 by PKM2 released AKT1S1 from raptor and facilitated its binding to 14-3-3, resulted in hormonal- and nutrient-signals independent activation of mTORC1 signaling and led accelerated oncogenic growth and autophagy inhibition in cancer cells. Decreasing S202/203 phosphorylation by TEPP-46 treatment reversed these effects. In RCCs and breast cancers, PKM2 overexpression was correlated with elevated S202/203 phosphorylation, activated mTORC1 and inhibited autophagy. Our results provided the first phosphorylome of PKM2 and revealed a constitutive mTORC1 activating mechanism in cancer cells.
Ultrafast Optical Microscopy of Single Monolayer Molybdenum Disulfide Flakes
Authors: Seo Minah , Yamaguchi Hisato , Mohite Aditya D. , Boubanga-Tombet Stephane , Blancon Jean-Christophe , Najmaei Sina , Ajayan Pulickel M. , Lou Jun , Taylor Antoinette J. , Prasankumar Rohit P.
Published: February 2016

We have performed ultrafast optical microscopy on single flakes of atomically thin CVD-grown molybdenum disulfide, using non-degenerate femtosecond pump-probe spectroscopy to excite and probe carriers above and below the indirect and direct band gaps. These measurements reveal the influence of layer thickness on carrier dynamics when probing near the band gap. Furthermore, fluence-dependent measurements indicate that carrier relaxation is primarily influenced by surface-related defect and trap states after above-bandgap photoexcitation. The ability to probe femtosecond carrier dynamics in individual flakes can thus give much insight into light-matter interactions in these two-dimensional nanosystems.
Pharmacological therapies for infantile hemangiomas: A clinical study in 853 consecutive patients using a standard treatment algorithm
Authors: Zhang Ling , Yuan Wei-En , Zheng Jia-Wei
Published: February 2016

Infantile hemangiomas are the most common infantile benign vascular tumor. While most infantile hemangiomas proliferate then involute, some may persist and require treatment for reasons including risk of disfigurement or functional impairment. Treatments currently include observation, pharmacological therapy, laser, cryosurgery, surgery and radiotherapy. Although pharmacological therapy is a well accepted treatment option, limited studies have evaluated the efficacy of different drug therapies. In this study, we compare different pharmacological modalities in the management of infantile hemangiomas. The study included 853 infants with proliferative infantile hemangiomas who were treated with topical timolol, oral propranolol, intralesional pingyangmycin, or intravenous vincristine from 2009 to 2012. Treatment stratification was based on clinical severity of the tumor. Response to the treatment was clinically evaluated and graded as: excellent, good, poor, or no response. Response to pharmacological therapies was excellent in almost all infantile hemangiomas. In addition, patients younger than 8 months responded highly to pharmacological treatment (89.1%), while patients older than 8 months were less responsive to treatment (36.3%). There were no instances of life-threatening complications. Overall, these findings support the efficacy of timolol, propranolol, pingyangmycin and vincristine in the treatment of infantile hemangiomas, especially in the youngest patient cohort (8 months or younger).
An unsupervised MVA method to compare specific regions in human breast tumor tissue samples using ToF-SIMS
Authors: Bluestein Blake M. , Morrish Fionnuala , Graham Daniel J. , Guenthoer Jamie , Hockenbery David , Porter Peggy L. , Gamble Lara J.
Published: February 2016

PCA-generated regions of interest (ROI) selection of imaging ToF-SIMS data allows chemical comparison of multiple breast cancer specimens.
Electrochemical redox signaling of hemoglobin in human whole blood and its relevance to anemia and thalassemia diagnosis
Authors: Amreen Khairunnisa , Kumar Annamalai Senthil
Published: February 2016

Direct electron transfer behaviour of hemoglobin in human whole blood on mesoporous carbon modified electrode and its clinical relevance to hemoglobin analysis and thalassemia disease diagnosis was demonstrated.
Self-assembling peptides for stem cell and tissue engineering
Authors: Tatman Philip D. , Muhonen Ethan G. , Wickers Sean T. , Gee Albert O. , Kim Eung-Sam , Kim Deok-Ho
Published: February 2016

Self-assembling peptides serve as a versatile tool in stem cell and tissue engineering for advancing next-generation medical therapies.
Modelling an electrochemically roughened porous platinum electrode for water oxidation
Authors: Weremfo Alexander , Lu Xunyu , Carter Paul , Hibbert D. Brynn , Zhao Chuan
Published: February 2016

The use of a central composite design to model the roughness of an electrochemically roughened Pt electrode and the surface with a well-defined nanostructure exhibits greatly improved catalytic activity towards oxygen evolution reaction.
Methanol synthesis via CO2hydrogenation over a Au/ZnO catalyst: an isotope labelling study on the role of CO in the reaction process
Authors: Hartadi Yeusy , Widmann Daniel , Behm R. Jürgen
Published: February 2016

Applying isotope labelling studies it is demonstrated that CO2is the main source for MeOH formation from CO2/CO/H2mixtures on Au/ZnO.
Computing UV/vis spectra using a combined molecular dynamics and quantum chemistry approach: bis-triazin-pyridine (BTP) ligands studied in solution
Authors: Höfener Sebastian , Trumm Michael , Koke Carsten , Heuser Johannes , Ekström Ulf , Skerencak-Frech Andrej , Schimmelpfennig Bernd , Panak Petra J.
Published: February 2016

UV/vis spectra of 2,6-bis(5,6-dialkyl-1,2,4-triazin-3-yl)pyridine (BTP) ligands are studied in solution using a combined computational and experimental approach.
Black phosphorene/monolayer transition-metal dichalcogenides as two dimensional van der Waals heterostructures: a first-principles study
Authors: You Baiqing , Wang Xiaocha , Zheng Zhida , Mi Wenbo
Published: February 2016

The electronic structure of black phosphorene/XT2(X = Mo, W; T = S, Se, Te) two dimensional heterostructures is presented using the first-principles method.
An N-heterocyclic carbene based MOF catalyst for Sonogashira cross-coupling reaction
Authors: Ezugwu Chizoba I. , Mousavi Bibimaryam , Asrafa Md. Ali , Mehta Akshay , Vardhan Harsh , Verpoort Francis
Published: February 2016

The post-synthetic modification of azolium containing MOFs generated a new heterogeneous N-heterocyclic carbene catalyst (1-Pd), which is very active for Sonogashira cross coupling reaction.
Synergistic effect of graphene and multi-walled carbon nanotubes composite supported Pd nanocubes on enhancing catalytic activity for electro-oxidation of formic acid
Authors: Yousaf Ammar Bin , Imran M. , Zeb Akif , Xie Xiao , Liang Kuang , Zhou Xiao , Yuan Cheng-Zong , Xu An-Wu
Published: February 2016

Synergistic effect of rGO/MWCNTs composite supported Pd nanocubes enhanced the performance of direct formic acid fuel cells.
The growth of a CH3NH3PbI3thin film using simplified close space sublimation for efficient and large dimensional perovskite solar cells
Authors: Guo Qiang , Li Cong , Qiao Wenyuan , Ma Shuang , Wang Fuzhi , Zhang Bing , Hu Linhua , Dai Songyuan , Tan Zhan'ao
Published: February 2016

We demonstrate a novel simplified close space sublimation (CSS) deposition for growing a high quality CH3NH3PbI3thin film in a low-vacuum and even non-vacuum oven.
Multiscale adsorption and transport in hierarchical porous materials
Authors: Coasne Benoit
Published: February 2016

This review presents the state-of-the-art of multiscale adsorption and transport in hierarchical porous materials.
Nitrogen-doped titanium dioxide (N-doped TiO2) for visible light photocatalysis
Authors: Ansari Sajid Ali , Khan Mohammad Mansoob , Ansari Mohd Omaish , Cho Moo Hwan
Published: February 2016

Energy level diagrams for undoped and N-doped TiO2 for visible light induced photocatalytic application.
Effect of sodium doping on the microstructure, lattice distortion and magnetic properties of GdMnO3 tiny single crystals
Authors: Nandy Anshuman , Roychowdhury Anirban , Kar Tanushree , Das Dipankar , Pradhan Swapan Kumar
Published: February 2016

10% monovalent sodium doping reduces the octahedral and lattice distortion in GdMnO3 tiny single crystals and introduces ferromagnetic ordering in the compound.
A novel phthalonitrile monomer with low post cure temperature and short cure time
Authors: Sheng Liping , Yin Changping , Xiao Jiayu
Published: February 2016

3-(2-Aminophenoxy)-phthalonitrile was designed and synthesized. Measurements show that the monomer has higher cure reactivity and can cure at lower temperatures in a short time and with a higher conversion, giving a better thermal stability.
Artificial extracellular matrix delivers TGFb1 regulating myofibroblast differentiation
Authors: Cheng Weilu , Xu Ruodan , Li Dalong , Bortolini Christian , He Jinmei , Dong Mingdong , Besenbacher Flemming , Huang Yudong , Chen Menglin
Published: February 2016

Spatiotemporally controlled release of transforming growth factor β1 from electrospun biomimetic nanofibers realized optimal cell viability and myofibroblast differentiation capacity, which holds great potential in wound healing application.
Anti-sintering ZrO2-modified Ni/α-Al2O3 catalyst for CO methanation
Authors: Liu Qing , Gu Fangna , Zhong Ziyi , Xu Guangwen , Su Fabing
Published: February 2016

The ZrO2-modified Ni/α-Al2O3 catalysts prepared by a modified impregnation method show obvious enhancement of Ni anti-sintering because of the special distribution of ZrO2 nanoparticles on the surface of the catalyst.
Mapping students' modes of reasoning when thinking about chemical reactions used to make a desired product
Authors: Weinrich M. L. , Talanquer V.
Published: February 2016

The central goal of this study was to analyze the complexity of students' explanations about how and why chemical reactions happen in terms of the types of causal connections students built between expressed concepts and ideas. We were particularly interested in characterizing differences in the types of reasoning applied by students with different levels of training in the chemistry, from college to graduate school. Using a qualitative research approach, we identified diverse modes of reasoning expressed by students when engaged in the analysis of different sets of chemical reactions selected to produce a targeted compound. Main findings indicate that dominant modes of reasoning varied with educational level and the nature of the task. Although participants applied diverse modes of reasoning, linear causal reasoning was prevalent across educational levels and types of tasks. Many students tended to generate explanations based on the identification of a single agent that caused a sequential chain of events. Advanced undergraduate students in our sample generated the most complex explanations. The results of our study have important implications for the development of causal mechanistic reasoning in chemistry.
TiNb2O7/graphene composites as high-rate anode materials for lithium/sodium ion batteries
Authors: Li Shuang , Cao Xi , Schmidt Charles N. , Xu Qian , Uchaker Evan , Pei Yi , Cao Guozhong
Published: February 2016

Layered TiNb2O7/graphene composites (TNO/G) are synthesized through a simple freeze drying process. Such a sandwiched structure combined advantages of graphene sheets and TiNb2O7(TNO) exhibiting much enhanced rate performance, storage capacity and cycling stability for both lithium and sodium ion insertion.
Effect of the protein corona on the colloidal stability and reactivity of LDH-based nanocarriers
Authors: Vasti Cecilia , Bedoya Dariana Aristizabal , Rojas Ricardo , Giacomelli Carla E.
Published: February 2016

The physicochemical properties of drug nanocarriers such as layered double hydroxides nanoparticles (LDH-NPs) determine their circulation times in biological media and their interaction with the targeted cells.
Direct-write printing of reactive oligomeric alkoxysilanes as an affordable and highly efficient route for promoting local adhesion of silver inks on polymer substrates
Authors: Kirikova Marina N. , Agina Elena V. , Bessonov Alexander A. , Sizov Alexey S. , Borshchev Oleg V. , Trul Askold A. , Muzafarov Aziz M. , Ponomarenko Sergei A.
Published: February 2016

A novel approach for improving the printability and adhesion of silver inks on flexible and stretchable polymeric substrates is reported.
A multifunctional nanocomposite for luminescence resonance energy transfer-guided synergistic monitoring and therapy under single near infrared light
Authors: Zhang Yu , Shen Ting-Ting , Zhang Hao-Li , Kirillov Alexander M. , Cai Hui-Juan , Wu Jiang , Liu Wei-Sheng , Tang Yu
Published: February 2016

In this report, we successfully implemented multiple functions into one nanocomposite, including the dual-mode monitoring of drug release and synergistic photothermal chemotherapy.
Activation of carbon dioxide by a terminal uranium–nitrogen bond in the gas-phase: a demonstration of the principle of microscopic reversibility
Authors: Dau Phuong D. , Armentrout P. B. , Michelini Maria C. , Gibson John K.
Published: February 2016

Spontaneous dissociative insertion of CO2 into an anionic gas-phase metal complex demonstrates the principle of microscopic reversibility.
Tandem vinyl insertion-/ring-opening metathesis copolymerization with ansa-6-[2-(dimesitylboryl)-phenyl]pyrid-2-ylamido zirconium complexes: role of trialkylaluminum and MAO
Authors: Wang Min , Wang Dongren , Widmann Laura , Frey Wolfgang , Buchmeiser Michael R.
Published: February 2016

Activation of Zr-bisalkyl complexes containing the η5-tetramethylcyclopentadienyl-6-[2-(dimesitylboryl)phenyl]pyrid-2-ylamido motif with MAO offers access to poly(ethylene)-co-poly(norbornene) with ROMP-derived sequences.
Flexible solid-state supercapacitors based on freestanding nitrogen-doped porous carbon nanofibers derived from electrospun polyacrylonitrile@polyaniline nanofibers
Authors: Miao Fujun , Shao Changlu , Li Xinghua , Wang Kexin , Liu Yichun
Published: February 2016

Freestanding nitrogen-doped porous carbon nanofibers were successfully fabricated and assembled in symmetric flexible solid-state supercapacitors with outstanding electrochemical performance.
New family of room temperature quantum spin Hall insulators in two-dimensional germanene films
Authors: Zhang Run-wu , Ji Wei-xiao , Zhang Chang-wen , Li Sheng-shi , Li Ping , Wang Pei-ji
Published: February 2016

Based on first-principles calculations, we predict that 2D germanene decorated with ethynyl-derivatives (GeC2X; X = H, F, Cl, Br, I) can be topological insulators with large band-gaps for room-temperature applications.
Adaptive cyber‐physical system attack detection and reconstruction with application to power systems
Authors: Ao Wei , Song Yongdong , Wen Changyun
Published: February 2016

Timely and automatic detection and reconstruction of cyber attack is crucial in maintaining safe operation of cyber‐physical systems. This study investigates the problem of unexpected cyber attack and its automatic recovery. First, detectability of attacks based on linear system theory is explored and some sufficient conditions of detecting state attacks and sensor attacks, respectively, are established. Subsequently two adaptive sliding mode observers with on line parameter estimation are designed to estimate state attacks and sensor attacks separately. Second, appropriate residual signals are constructed and it is shown that they approach to the attacks with ultimately uniformly bounded errors. Finally, as an illustration of attack detection and reconstruction, the results are applied to an IEEE 39 bus power system with 10 generators and 39 buses, which shows the effectiveness of the proposed adaptive schemes.
High‐speed directional protection based on cross correlation of Fourier transform components of voltage and current
Authors: Saleki Ghasem , Samet Haidar , Ghanbari Teymoor
Published: February 2016

In this study, a new algorithm for directional protection, based on cross correlation of Fourier transform components of voltage and current for each phase is proposed. The fault is detected using k‐nearest neighbour algorithm. By comparing the fifth‐nearest neighbour of each sample with an adaptive threshold, the fault is detected. The adaptive threshold is derived by a moving window with length equal to 1 ms. Using Fourier transform, the fifth sinusoidal component of the measured voltage and current for each phase is extracted. Then the cross correlation of the voltage and current components is calculated. The calculated cross correlation signal is passed through a low‐pass filter. By comparison of the filtered signal with a predefined threshold, fault direction is determined. It is confirmed that the fault direction can be identified in less than 8 ms with high accuracy of nearly 99%. More than 6500 scenarios are considered for different fault conditions to evaluate the proposed method. Furthermore, using some experimental results the proposed method performance is confirmed. The simulation and experimental results show that the proposed method has high speed, good accuracy, and sensitivity.
Particle tracing modelling on moisture dynamics of oil‐impregnated transformer
Authors: Cui Yi , Ma Hui , Saha Tapan , Ekanayake Chandima , Martin Daniel
Published: February 2016

An accurate estimation of moisture in oil‐impregnated cellulose of a transformer is difficult due to the complex moisture dynamics inside the transformer, which is highly influenced by the temperature and dimension of the transformer. In this study, a novel particle tracing method is proposed for estimating the moisture in transformers. Different from the conventional approaches using Fick's diffusion law, the proposed method formulates moisture diffusion from a microscopic view of water particles’ motion. Especially, the transmission probability of water particles is employed to correlate the microscopic particles’ motion with the macroscopic moisture distribution. The proposed particle tracing method is applied to model moisture dynamics in both pressboard specimens and a prototype transformer. Extensive moisture diffusion and ageing experiments are carried out to verify the proposed method.
Measurement‐based wireless network planning, monitoring, and reconfiguration solution for robust radio communications in indoor factories
Authors: Gong Xu , Trogh Jens , Braet Quentin , Tanghe Emmeric , Singh Prashant , Plets David , Hoebeke Jeroen , Deschrijver Dirk , Dhaene Tom , Martens Luc , Joseph Wout
Published: February 2016

Nowadays, the harsh industrial environment remains one of the vital challenges for an effective deployment of wireless technologies in factories to promote the industrial upgrade. In this study, a complete solution is proposed for robust radio communications in indoor factories. Herein, measurement setups are integrated with industrial mobile facilities, e.g. an automated guided vehicle and a mobile robot. Calibration is advised for accurately revealing an industrial radio environment. A hybrid sequential design strategy is used to enhance the efficiency of the measurement campaign. This further leads to a surrogate modelling based radio environment map, which facilitates a holistic view and evaluation of the radio quality of service over the target shop floor. In addition, an over‐dimensioning heuristic is proposed to guarantee that every target location can be wirelessly covered by at least two access points (APs). Moreover, the smart switch mechanism dynamically powers on/off the over‐dimensioned APs, so as to ensure full coverage even at the presence of physical disturbance. The investigation on two real factories and the coverage prediction tool WHIPP further demonstrates the solution's effectiveness. Eventually, a rich outlook is drawn for the roadmap towards an artificially intelligent system for robust industrial wireless communications.
Dual‐port pulsed differential‐mode current injection method for high‐level electromagnetic pulse radiated susceptibility testing
Authors: Lu Xinfu , Wei Guanghui , Pan Xiaodong , Fan Lisi , Wan Haojiang
Published: February 2016

A dual‐port pulsed differential‐mode current injection (DPDCI) method is proposed for high‐level wide‐band electromagnetic pulse (EMP) radiated susceptibility testing of interconnected systems. By employing the designed wide‐band differential‐mode (DM) coupling device, the susceptibility of the equipment under test (EUT) at both ends can be assessed at the same time. In order to enforce the equivalence between EMP radiation and DPDCI, the methods to obtain the waveforms of the two equivalent injection sources and their time delay difference are proposed. By using the linear extrapolation method, the results for high‐level EMP radiation can be reproduced by DPDCI even if the responses of the two EUTs are non‐linear. To confirm the effectiveness of the proposed method, the conversion of common‐mode interference into DM disturbance on the cable inside the EUT is assessed by experiment and the impact of connecting the injection devices into the system is discussed. By using a typical interconnected system composed of a coaxial cable and typical non‐linear equipment at both ends, the feasibility of the proposed method is verified.
Topische antiinflammatorische Therapieoptionen
Authors: Siebelmann Sebastian , Bucher Franziska , Grajewski Rafael , Steven Philipp
Published: February 2016

Inflammatorische Prozesse des Auges gehören zu den häufigsten Entitäten in der Augenheilkunde. Die Anwendung antientzündlicher Substanzen ist daher für den Behandler eine zentrale therapeutische Option. Hierbei kommen zumeist aufgrund der guten Zugänglichkeit des Auges topische Applikationen zur Anwendung. Substanzgruppen wie Antiallergika, nichtsteroidale Antirheumatika, Glukokortikoide, Calcineurininhibitoren, Serumaugentropfen sowie neuere, noch in der Entwicklung befindliche Substanzen werden spezifisch sowohl in schmalen als auch in breiten Indikationsspektren eingesetzt, weshalb die Kenntnis der Wirkmechanismen und der potenziellen Nebenwirkungen von großer Bedeutung ist. Dieser Artikel soll einen Überblick über die derzeitig verfügbaren antiinflammatorisch wirksamen Substanzen geben, die topisch verabreicht werden können. Hierbei wird auf eine detaillierte Anwendungsbeschreibung (Dosis, Applikationshäufigkeit, Dauer usw.) in Bezug auf die einzelnen Krankheitsbilder bewusst verzichtet. Ziel ist es, dem Leser pharmakologisches Basiswissen mit direktem ophthalmologischen Bezug zu vermitteln.
Iminoacyl Alkyl Complexes of Zirconium Supported by a Ferrocene-Linked Diphosphinoamide Ligand Scaffold
Authors: Halcovitch Nathan R. , Fryzuk Michael D.
Published: February 2016

Zirconium dialkyl complexes of the general formula fc(NPiPr2)2ZrR2 (where fc = 1,1′-ferrocenyl, R = CH3, CH2Ph, CH2tBu, tBu) have been synthesized and characterized via the addition of alkyl lithium or potassium benzyl derivatives to the dichloride complex fc(NPiPr2)2ZrCl2(THF). Addition of 2,6-dimethylphenylisocyanide to these alkyl derivatives generates the corresponding mono iminoacyl alkyl zirconium complexes. On thermolysis, the iminoacyl moiety containing a benzyl substituent undergoes rearrangement to yield a new complex that contains an alkene-amido fragment. Mechanistic studies point to a 1,2 hydrogen shift as the rate-determining step.
Reducing rainfall amount has a greater negative effect on the productivity of grassland plant species than reducing rainfall frequency
Authors: Gibson-Forty Eleanor V. J. , Barnett Kirk L. , Tissue David T. , Power Sally A.
Published: February 2016

The productivity of semiarid Australian grassland ecosystems is currently limited by water availability and may be impacted further by predicted changes in rainfall regimes associated with climate change. In this study, we established a rainfall manipulation experiment to determine the effects of reduced frequency (RF; 8 days between water events) and reduced magnitude (RM; 50% reduction in amount) of rainfall events on the physiology and above- and below-ground growth of five grassland plant species with differing traits. Native C4 grasses exhibited the highest productivity in well watered, control (Cont) conditions, as well as in RF and RM treatments. The RF treatment generally had little effect on total biomass, rooting distributions or photosynthesis, suggesting species were relatively tolerant of reduction in the frequency of rainfall events. However, the RM treatment had a negative effect on total biomass and physiology, and generally resulted in a shift towards shallower rooting profiles. Overall, the reduction in biomass was greater in RM than RF, suggesting that rainfall magnitude may be a more important determinant of grassland productivity and composition than the frequency of rainfall events under future climates.
Dietary-induced gestational iron deficiency inhibits postnatal tissue iron delivery and postpones the cessation of active nephrogenesis in rats
Authors: Sun Mary Y. , Woolley Joseph C. , Blohowiak Sharon E. , Smith Zachary R. , Siddappa Ashajyothi M. , Magness Ronald R. , Kling Pamela J.
Published: February 2016

Gestational iron deficiency (ID) can alter developmental programming through impaired nephron endowment, leading to adult hypertension, but nephrogenesis is unstudied. Iron status and renal development during dietary-induced gestational ID (<6 mg Fe kg–1 diet from Gestational Day 2 to Postnatal Day (PND) 7) were compared with control rats (198 mg Fe kg–1 diet). On PND2–PND10, PND15, PND30 and PND45, blood and tissue iron status were assessed. Nephrogenic zone maturation (PND2–PND10), radial glomerular counts (RGCs), glomerular size density and total planar surface area (PND15 and PND30) were also assessed. Blood pressure (BP) was measured in offspring. ID rats were smaller, exhibiting lower erythrocyte and tissue iron than control rats (PND2–PND10), but these parameters returned to control values by PND30–PND45. Relative kidney iron (µg g–1 wet weight) at PND2-PND10 was directly related to transport iron measures. In ID rats, the maturation of the active nephrogenic zone was later than control. RGCs, glomerular size, glomerular density, and glomerular planar surface area were lower than control at PND15, but returned to control by PND30. After weaning, the kidney weight/rat weight ratio (mg g–1) was heavier in ID than control rats. BP readings at PND45 were lower in ID than control rats. Altered kidney maturation and renal adaptations may contribute to glomerular size, early hyperfiltration and long-term renal function.
Parity in the plural
Authors: Peled Yael
Published: February 2016

The politics of language raises a number of concerns pertaining to the question of equality, particularly in the context of language policy formulation, analysis and evaluation. At the same time, however, both ‘equality’ and ‘language’ are relatively vague notions, which may be interpreted in different ways, and which therefore yield very different understandings when combined together in different circumstances and in service of different purposes. This conceptual vagueness, I argue, requires normative reflections that are public policy-oriented to engage in a more nuanced conceptual analysis in the process of formulating moral arguments on the basis of moral intuitions. I therefore map a number of possible conceptions of both ‘equality’ and ‘language’, and discuss in detail the notion of ‘complex linguistic equality’ as one example of their possible permutation. I conclude by arguing for the importance of more engaged work between political theory and sociolinguistics for the sake of advancing both theory-building and practical application.
Effect of Nb-Mo additions on precipitation behaviour in V microalloyed TRIP-assisted steels
Authors: Abbasi E. , Rainforth W. M.
Published: February 2016

The microstructural evolution and precipitation behaviour of Nb-V-Mo and single V containing transformation-induced plasticity-assisted steels with an acicular/bainitic ferrite matrix were investigated by a heat treatment up to the austenite formation range. It was found that during the heating stage the acicular/bainitic ferrite matrix resisted recrystallisation, while cementite and martensite were decomposed and austenite was formed in the acicular/bainitic ferrite. Both Nb-V-Mo and V containing steels after the heat treatment showed a microstructure consisting of a polygonal ferrite matrix with small islands of pearlite. During these transformations, the microscopy observations showed that 0.04 wt% Nb and 0.08 wt% Mo additions to the 0.16 wt% V microalloyed steel considerably reduced the growth-coarsening of microalloy precipitates.
Divine callings: religious sensemaking in the organizational founding process
Authors: Scheitle Christopher P. , Adamczyk Amy
Published: February 2016

Organizational scholars have not considered the potential power of religion as a sensemaking tool. Religion scholars have wondered whether religious sensemaking is simply a post hoc justification for behavior, or whether it can shape future actions. In this article, we present mixed
methods research that gets at the intersection of these issues. In interviews with founders of religious nonprofit organizations, we find that many frame their founding experiences in religious terms, such as believing that God gave them the idea for their organization or attributing certain
founding events to divine intervention. We then examine data from a survey of young religious nonprofits and find that reports of personal religious experiences are more common among primary founders compared to other leaders. We also find that those founders reporting certain religious experiences
work more hours in the organization, suggesting that sensemaking strategies could have consequences for individuals’ behavior.
MAESTROweb: a web server for structure-based protein stability prediction
Authors: Laimer Josef , Hiebl-Flach Julia , Lengauer Daniel , Lackner Peter
Published: February 2016

Summary: The prediction of change in stability upon point mutations in proteins has many applications in protein analysis and engineering. We recently adjoined a new structure-based method called MAESTRO, which is distributed as command line program. We now provide access to the most important features of MAESTRO by an easy to use web service. MAESTROweb allows the prediction of change in stability for user-defined mutations, provides a scan functionality for the most (de)stabilizing n-point mutations for a maximum of n = 5, creates mutation sensitivity profiles and evaluates potential disulfide bonds. MAESTROweb operates on monomers, multimers and biological assemblies as defined by PDB.

Availability and implementation: MAESTROweb is freely available for non-commercial use at https://biwww.che.sbg.ac.at/maestro/web.

Contact:  peter.lackner@sbg.ac.at
Multi-task consensus clustering of genome-wide transcriptomes from related biological conditions
Authors: Niu Zhen , Chasman Deborah , Eisfeld Amie J. , Kawaoka Yoshihiro , Roy Sushmita
Published: February 2016

Motivation: Identifying the shared and pathogen-specific components of host transcriptional regulatory programs is important for understanding the principles of regulation of immune response. Recent efforts in systems biology studies of infectious diseases have resulted in a large collection of datasets measuring host transcriptional response to various pathogens. Computational methods to identify and compare gene expression modules across different infections offer a powerful way to identify strain-specific and shared components of the regulatory program. An important challenge is to identify statistically robust gene expression modules as well as to reliably detect genes that change their module memberships between infections.

Results: We present MULCCH (MULti-task spectral Consensus Clustering for Hierarchically related tasks), a consensus extension of a multi-task clustering algorithm to infer high-confidence strain-specific host response modules under infections from multiple virus strains. On simulated data, MULCCH more accurately identifies genes exhibiting pathogen-specific patterns compared to non-consensus and nonmulti-task clustering approaches. Application of MULCCH to mammalian transcriptional response to a panel of influenza viruses showed that our method identifies clusters with greater coherence compared to non-consensus methods. Further, MULCCH derived clusters are enriched for several immune system-related processes and regulators. In summary, MULCCH provides a reliable module-based approach to identify molecular pathways and gene sets characterizing commonality and specificity of host response to viruses of different pathogenicities.

Availability and implementation: The source code is available at https://bitbucket.org/roygroup/mulcch

Contact:  sroy@biostat.wisc.edu

Supplementary information:  Supplementary data are available at Bioinformatics online.