bluuebunny/crossref_metadata_2025 huggingface dataset:
Bimekizumab Efficacy Through 3 Years in Patients with Moderate to Severe Plaque Psoriasis: Long-term Pooled Analysis from BE BRIGHT
Authors: Lebwohl Mark , Strober Bruce , Foley Peter , Langley Richard G. , Tada Yayoi , Hampton Philip , Davis Leah , Wiegratz Susanne , Hoepken Bengt , Lambert Jérémy , Kokolakis Georgios
Published: January 2024

Introduction: A key factor of biologic discontinuation in plaque psoriasis patients is loss of response over time; long-term treatment efficacy is therefore important.1 Here, 3-year efficacy of bimekizumab (BKZ) from a pooled analysis of patients with moderate to severe plaque psoriasis across 3 phase 3 clinical trials and their open-label extension (OLE) is reported.

Procedure/study: Data were pooled from the 52-week BE VIVID and 56-week BE SURE and BE READY phase 3 trials, and their common OLE BE BRIGHT.2–5 Included patients received BKZ 320 mg every 4 weeks (Q4W) then switched to Q4W or Q8W maintenance dosing from Week 16 onwards, and entered the OLE; from OLE Week 48 or the next scheduled visit, all patients received BKZ 320 mg Q8W. Proportions of patients achieving ≥90% improvement from baseline in Psoriasis Area and Severity Index (PASI 90), PASI 100, and Dermatology Life Quality Index (DLQI) 0/1 are reported through Year 3 using modified non-responder imputation: patients who discontinued treatment due to lack of efficacy or treatment-related adverse events were considered non-responders at subsequent timepoints; multiple imputation was used for all other missing data.

Results: 771 patients received BKZ continuously in the feeder studies and entered the OLE. Among these, at Week 16, 90.9%, 65.8%, and 71.5% achieved PASI 90, PASI 100, and DLQI 0/1, respectively. At Year 1, 93.7%, 76.6%, and 83.1% of all BKZ-treated patients achieved PASI 90 (Week 52), PASI 100 (Week 52), and DLQI 0/1 (Week 48/52), respectively. Responses were durable to Year 3 (OLE Week 96): 91.0%, 70.3%, and 82.8% of all BKZ-treated patients achieved PASI 90, PASI 100, and DLQI 0/1, respectively. Similar trends were observed in the subset of patients that received BKZ Q4W/Q8W/Q8W (initial/maintenance/OLE).

Conclusion: High and durable clinical and health-related quality of life responses were observed over 3 years of BKZ treatment across 3 phase 3 trials and their OLE.

Funding: UCB Pharma.
Overview of Clinical Trials With Efgartigimod in Autoimmune Blistering Diseases: Pemphigus Vulgaris and Pemphigus Foliaceus (ADDRESS and ADDRESS+) and Bullous Pemphigoid (BALLAD and BALLAD+)
Authors: Vassileva Snejina , Murrell Dedee F. , Culton Donna A. , Ujiie Hideyuki , Hertl Michael , Goebeler Matthias , Sinha Animesh A. , Schmidt Enno , Stoykov Ivaylo , Verheesen Peter , Borradori Luca , Werth Victoria P. , Joly Pascal
Published: January 2024

Introduction & Objectives: Efgartigimod is an engineered Fc fragment that inhibits the activity of the neonatal Fc receptor (FcRn), thereby reducing levels of circulating IgG including pathogenic IgG autoantibodies. Pemphigus vulgaris (PV), pemphigus foliaceus (PF), and bullous pemphigoid (BP) are autoimmune blistering diseases. Pemphigus is mediated by IgG autoantibodies targeting desmoglein (Dsg)-3 in PV, and Dsg-1 in mucocutaneous PV (in addition to Dsg-3), while PF is attributed to IgG autoantibodies against Dsg-1 only. Dsg-3 and Dsg-1 are desmosomal proteins mediating keratinocyte cell-cell adhesion. BP is mediated by IgG autoantibodies against BP180 (type XVII collagen) and BP230 structural proteins of the dermal-epidermal junction.
Materials & Methods: ADDRESS is a multicenter, randomized, double-blind, placebo-controlled trial evaluating efficacy and safety of efgartigimod in patients with PV or PF (NCT04598451). Participants are undergoing randomization (2:1) to receive subcutaneous efgartigimod co-formulated with PH20 or placebo/PH20 on top of oral prednisone (or equivalent). Primary endpoint is the proportion of patients with PV or PF who achieve complete remission on minimal therapy (CRmin) within 30 weeks.
BALLAD is a global, multicenter, phase 2/3, randomized, double-blind, placebo-controlled trial evaluating efficacy and safety of subcutaneously administered efgartigimod in patients with BP (NCT05267600). Part A will be a proof-of-concept study and recruit 40 participants, while the Part B confirmatory study will recruit 120 participants. Parts A and B will be identical in schedule, structure, assessments, and conduct. Primary endpoint is the proportion of participants in complete remission off oral corticosteroid therapy for ≥8 weeks at week 36.
Results & Conclusions: As of February 28, 2023, 222 participants have been enrolled into ADDRESS and enrolment of BALLAD has started. It is anticipated that the recruitment of the ADDRESS full study and BALLAD part A will be completed, and a further update will be given at the time of presentation.
Evaluation of Antioxidants’ Ability to Enhance Hyaluronic Acid-Based Topical Moisturizers
Authors: Romanowitz Daniel , Zeichner Joshua , Lain Edward , Mariwalla Kavita , Kirchner Frank , Weise Julia , Draelos Zoe
Published: January 2024

Introduction: Hyaluronic acid (HA) is a unique molecule with multiple biological activities. In skin, HA plays an essential role as a humectant, capable of binding up to 1000 times its mass with water, leading to both skin moisturization and extracellular matrix rigidity. HA concentration and synthesis decreases significantly in aging skin, due to exogenous and endogenous factors, including photoaging and HA metabolism, respectively. A key driver for HA degradation and decrease in concentration is mediated via the induction of reactive oxygen species (ROS) and other free radicals. In this study, we evaluate antioxidant ingredients essential in the development of next-generation multi-weight HA-based topical formulations aimed at leveraging hyaluronic acid’s ability to maximize anti-aging properties.
Methods: Two antioxidants, glycine saponin and glycyrrhetinic acid, were evaluated for stimulation of endogenous HA production and inhibition of endogenous hyaluronidase activity in an in vitro and cell-free assay.
Results: The antioxidant glycine saponin induced endogenous HA synthesis in keratinocytes, while the antioxidant glycyrrhetinic acid demonstrated an approximately 54% reduction of hyaluronidase activity for the HA-degrading enzyme HYAL1.
Conclusion: This study demonstrates the ability of two antioxidants (glycine saponin and glycyrrhetinic acid, essential in the development of the next generation of multi-weight HA plus antioxidant complex-based topical skin formulations) to limit the signs of aging skin, addressing limitations of many currently available topical HA-based formulations.
“Who is my Neighbour? Interfaith Dialogue and Theological Formation” (Responses)
Authors: Jean Duhaime , Gilbert Sherril , Guillet Hassan
Published: January 2024

The following are three response papers that were presented at the “Who is My Neighbour? Interfaith Dialogue and Theological Formation Conference,” held on October 19, 2022, and are indirectly responding to Amy-Jill Levine's discussion on Christian-Jewish dialogue.

The first response paper by Jean Duhaime, entitled “Christian-Jewish Dialogue and Theological Formation,” discusses how Christian-Jewish dialogue has been viewed and theologically negotiated in the Catholic tradition since Vatican II. By also addressing various Jewish reactions to the shift in Catholic attitudes towards the Jewish tradition, Duhaime illustrates the work still needed to be done for the Catholic Church to clarify its understanding of the relationship between Christianity and Judaism while simultaneously highlighting the value of including Jewish-Christian dialogue in the formation and training of religious leaders.

The second response paper by Sherril Gilbert, entitled “Why Training in the Art of Interreligious Dialogue Is Necessary for Theological Education: Thinking About ‘Who Is My Neighbour?’ From a Jewish Perspective,” discusses her personal experience in the seminary and her work as a Rabbi in multifaith contexts. Rabbi Sherril Gilbert’s response shifts the focus from the dialogue of theological exchange to what interreligious dialogue theorists would call “the dialogue of life” – which is to say, she articulates the wholistic value of interfaith dialogue, and, in doing so, demonstrates why it is crucial to incorporate a concern for interfaith dialogue into modern theological education.

The last response paper by Hassan Guillet, entitled “La Table interreligieuse de concentration du Québec: A Case Study” examines his personal experiences with interfaith dialogue during the COVID-19 pandemic, as a founding member of the Table Interreligieuse de concertation du Québec. He explains how this experience opened his eyes to the power of interfaith dialogue and collaboration, and also to the need to expand interfaith dialogue initiatives to include as many faith communities as possible, including Indigenous faith communities that are not as clearly demarcated as, say, Christianity, Judaism, or Islam
THE IMPORTANT ROLE OF E-COMMERCE IN FORMING COMMUNITY FINANCIAL LITERACY
Authors: Gusti Girang Permata , da Hil
Published: January 2024

This research discusses the important role of e-commerce in shaping people’s financial literacy. E-commerce has become one of the main pillars of Indonesia’s digital economy, and the increased use of this platform has had a significant impact on people’s financial behavior and understanding. In this study, we analyzed data from secondary sources, including reports and statistics related to e-commerce site visits and financial transactions. We explore monthly trends and growth in visits to popular e-commerce sites in Indonesia during the first quarter of 2023. In addition, we examine how promotional programs and discounts in e-commerce can influence people’s shopping behavior and awareness about saving and investing. The results of this research highlight the importance of e-commerce as a means of education and financial literacy for Indonesian people in the digital era.
A CRITICAL REVIEW OF THE RELATIONSHIP BETWEEN EMPLOYEE ENGAGEMENT AND ORGANIZATIONAL SUCCESS IN THE NIGERIAN OIL AND GAS SECTOR
Authors: James Oladapo Olakunle , Udeh Chioma Ann , Daraojimba Chibuike , Ogedengbe Damilola Emmanuel , Elufioye Oluwafunmi Adijat , Samod Busari Olumuyiwa
Published: January 2024

Employee engagement has increasingly been recognized as a pivotal factor in driving organizational success. This review examines the intricate relationship between employee engagement and organizational success within the context of the oil and gas sector in Nigeria. The primary objective of this research is to synthesize existing literature to understand how engagement strategies influence organizational outcomes in this high-stakes industry. The review draws on a range of empirical studies, industry reports, and theoretical frameworks to explore the dynamics of employee engagement specific to the cultural, economic, and operational environments of Nigeria’s oil and gas companies. It delves into the unique challenges faced by these organizations, such as fluctuating oil prices, regulatory pressures, and socio-economic impacts on workforce morale and productivity. Key insights suggest that employee engagement in the Nigerian oil and gas sector is significantly correlated with improved organizational performance indicators, including increased productivity, higher safety standards, and enhanced competitive advantage. The review also identifies successful engagement practices, such as inclusive leadership, career development opportunities, and recognition programs, which have been adapted to the local context. The conclusions underscore the necessity for oil and gas companies in Nigeria to invest in robust employee engagement strategies. It is posited that such investment not only fosters a committed and motivated workforce but also catalyzes organizational resilience and sustainability. The review calls for further empirical research to refine engagement models and strategies that are culturally congruent and economically viable in the Nigerian context, thereby contributing to the broader discourse on employee engagement and organizational success.
HYGIENE FACTORS AND JOB SATISFACTION OF MOTORCYCLE DEALER EMPLOYEES IN 3RD DISTRICT OF LAGUNA
Authors: M. Tilap Geraldine
Published: January 2024

Employee job satisfaction is vital in enhancing productivity, commitment, and retention in organizations. However, motorcycle dealership employees in the Philippines meet several barriers, including extended hours of work, low pay, a lack of benefits, and limited career growth for advancement. These challenges negatively impact job satisfaction, reducing productivity and dedication and increasing employee turnover. The study utilized a quantitative descriptive correlational research method to examine hygiene and motivational factors affecting job satisfaction among motorcycle employees in the 3rd district of Laguna, Philippines. The study found that hygiene factors such as working conditions, coworker relations, supervisor quality, base wage and salary, policies and rules, and status affect employee job satisfaction. Furthermore, Hygiene factors were identified as essential in increasing job satisfaction. Employers should prioritize addressing these elements to maintain and improve hygiene factors and focus on maintaining high levels of job satisfaction and providing opportunities for growth and advancement. Regular surveys or assessments should be conducted to continuously monitor and address hygiene factors. This study emphasizes the importance of understanding and enhancing employee job satisfaction to foster organizational productivity, commitment, and retention. The study aimed to contribute insights into how hygiene factors impact job satisfaction within the motorcycle dealership industry. However, the research focused solely on the 3rd district of Laguna, potentially limiting the generalizability of findings to other regions or industries.
EMPOWERING FUTURE FINANCIAL LEADERS: AN EXAMINATION OF PEER-LED FINANCIAL WORKSHOPS AND THEIR IMPACT ON FINANCIAL DECISION-MAKING AMONG NIGERIAN SECONDARY SCHOOL STUDENTS
Authors: Olaoluwa Oladayo Gbolahan , Abitoye Oluwabosoye , Daraojimba Chibuike , Abiola Abdul Adekunle , Oriji Oluwafunmilola
Published: January 2024

Developing financial literacy in the early years of secondary education is essential for forming responsible financial decisions as an adult. Financial literacy is an essential life skill. This study examines how peer-led financial workshops affect secondary school students in Nigeria’s ability to make financial decisions. It focuses on how these workshops affect students’ knowledge, attitudes, and financial behaviors. Quantitative and qualitative data were collected to assess the outcomes of these workshops. The quantitative analysis revealed a significant improvement in students’ financial knowledge, with an approximate 25% increase in their scores on financial knowledge-related questions. Furthermore, students exhibited more positive financial attitudes, showing increased confidence in managing money and recognizing the importance of financial planning. Most notably, students displayed changes in financial behaviors, with heightened inclinations to save, reduced impulsive spending, and more prudent debt management practices. Qualitative interviews provided deeper insights into students’ experiences, emphasizing that the workshops increased financial knowledge and empowered students to make meaningful changes in their financial decision-making. Peer influence and relatability played a pivotal role in this transformation, underscoring the effectiveness of peer-led financial workshops. The implications of these findings are profound for financial education in Nigerian secondary schools. The study underscores the promise of peer-led workshops, the importance of cultural sensitivity, the cultivation of positive financial mindsets, and the need for sustainability in financial education programs. While the study acknowledges its limitations, including sample size and the short-term focus, it provides a robust foundation for future research in longitudinal studies, comparative analysis, cultural influences, teacher preparedness, resource-efficient models, and specific financial outcomes. In conclusion, this research contributes to the broader discourse on financial education by demonstrating the significant impact of peer-led financial workshops in Nigerian secondary schools. It highlights the potential for equipping students with the knowledge and skills necessary to make informed and responsible financial decisions, ultimately fostering financial well-being and success in their futures.
ENTREPRENEURIAL DEVELOPMENT INITIATIVE ON MICRO ENTERPRISE SUSTENANCE IN NNEWI, ANAMBRA STATE, NIGERIA
Authors: Ndubuisi Levi Nwosu
Published: January 2024

In recent times, the important of entrepreneurship, development cannot be over emphasized. Entrepreneurship development has been found to be panacea through with job could be created and poverty reduced to the minimum. The broad objective of the study was to examine the entrepreneurial development initiative and micro enterprise sustenance in Nnewi, Anambra State. The hypotheses were developed as State Economic Empowerment and Development Strategy (SEEDS) initiative has no significant effect on micro enterprises in Nnewi, Anambra State. There is no significant relationship between National Poverty Eradication Programme (NAPEP) initiative and micro enterprises sustenance. The sample size for the study was 350. The hypotheses were analyse with regression analyses, correlation model. The findings revealed that the NAPEP initiative employed in the study area do have a significant relationship with the micro enterprises sustenance. The findings also revealed that the major challenges faced by the micro enterprises are lack of capital and lack of stated business mission, which are the topmost challenges faced by majority of enterprises. It was recommended that government and other policy makers at all level should intensify and ensure that more micro enterprises benefit from the SEED initiative in place already, and if possible initiative new ideas, since it has shown positive effect on the delivery of the core mandates of micro enterprises, which brings about creation of employment, poverty reduction, economic development, etc. Based on the result from the findings, it is also recommended that upcoming micro enterprises should be encouraged through sensitization, financing, provision of necessary facilities etc. in order to reduce if not eradicate poverty level in the area , as it has been shown that NAPEP initiatives have relationship with the sustenance of micro enterprises.
SIMULTANEOUS PROJECTION OF WORLD MULTIPLE CRUDE OIL PRICE BENCHMARKS VIA HYBRIDE OF PARTICLE SWARM OPTIMIZATION-GRAVITATIONAL SEARCH ALGORITHM REDESIGNED NEURAL NETWORKS
Authors: Isaac Samson , Thomas Lass Barna
Published: January 2024

Conventional methods such as econometrical and statistical models are no longer feasible to handle the nonlinear, non-stationary, chaotic, volatile, and complex nature of crude oil prices due to their linearity nature; computational intelligence techniques were proposed to address these issues. More so, single modelling principle and traditional methods have not been effective enough in forecasting of crude oil prices, hybrid modelling principles have been employed to predict crude oil prices by researchers with better improvements. A group researchers opined that the use of hybrid models can also reduce the risk of choosing an inappropriate model because the use of a single model cannot always accurately forecast the extremely complex crude oil price time-series. A combination method can be applied to multiple forecasts and perform linear or nonlinear combinations of the forecasts, leading to an aggregate forecast. However, no research is found to have used the hybrid of gravitational search algorithm (GSA) and particle swarm optimization (PSO) to train artificial neural network (ANN) for simultaneous prediction of crude oil price benchmarks of WTI, Brent and Dubai. More so, most researchers have dwelled on only West Texas Intermediate (WIT) crude oil spot prices as their benchmark.
DESIGN AND FABRICATION OF HEATING DEVICE FOR VEGETABLE OIL USED FOR DIESEL ENGINES
Authors: Minh Tuan Pham , Van Thuc Pham , Dao Nam Cao
Published: January 2024

Countries worldwide are recently interested in economic efficiency in line with protecting environmental protection. Generally, optimization of cetane number, expanding fuel sources, and producing clean fuels with less pollution at the development trend in diesel fuel. Faced with that situation, global energy security is one of the top goals worldwide that can be ensured by diversifying energy resources parallel with minimizing fossil energy dependence. Among solutions, biofuel in internal combustion engines is a potential approach that receives great attention from global researchers. Among biofuel sources, vegetable oil or animal fat can be employed directly on compression-ignition internal combustion engines. This study presents a method to design and manufacture a system that utilizes exhaust heat with integrated electrical energy to heat vegetable oil for direct use in diesel engines.
IOT DEVICE SECURITY RISKS: A COMPREHENSIVE OVERVIEW AND MITIGATION STRATEGIES
Authors: Iwuanyanwu Uzoamaka , Omotola Oyewole Olajumoke , Gilbert Fakeyede Ololade , Chinedu Okeleke Evelyn , Jonathan Apeh Apeh
Published: January 2024

The research paper delves into the intricate realm of IoT device security, unravelling the multifaceted risks and presenting a nuanced exploration of mitigation strategies. A comprehensive literature review unveils common security threads and the current state of IoT security measures. The subsequent analysis identifies security risks, including unauthorized access, encryption lapses, authentication weaknesses, physical vulnerabilities, and privacy concerns. Mitigation strategies encompass technical measures, policy frameworks, and user education, forming a holistic approach. The paper concludes by outlining recommendations for future research, emphasizing interdisciplinary collaboration, dynamic threat modelling, privacy-preserving technologies, standardization, certification, and blockchain integration. Envisioning a secure and connected future, the research underscores the pivotal role of manufacturers, policymakers, and users in shaping a resilient IoT landscape.
THE IMPLEMENTATION OF STRATEGIC INNOVATION MANAGEMENT AND ITS EFFECT ON FIRM INNOVATION PERFORMANCE IN INDONESIAN WOMEN ENTREPRENEUR ASSOCIATION
Authors: Tricahyono Dodie , Rismayani Risris , Firli Anisah , Rahadian Dadan , Putri MedianyKriseka , Rahayu Sri
Published: January 2024

Entrepreneurship provides opportunity for women, due to its flexible participation characteristic. Entrepreneurial activities for women would not only provide economic benefit, but also positive social impact for them and their families. However, entrepreneurial business performance requires great management effort over various aspects. One key aspect that would be focused in this research is the management of innovation. This study aimed to investigate Firm Innovation Performance based on the effect of factors such as Product Innovation, Process Innovation, and Market Innovation. The object of the research was the West Java Chapter of Indonesian Women Entrepreneur Association.
STUDY OF SECURITY FEATURES PRESENT IN NEPALI PASSPORT
Authors: Giri Roshan , Prasad Chimouriya Shanker , Ram Ghimire Bal
Published: January 2024

Security features present on Nepali passport are examined with the help of Video Spectral Comparator. Mainly examination is carried out with application ultra-violet light, normal light, oblique light and transmitted light. We obtain different types of security features including florescence, ghost image, binding thread, optical fiber, punched number, barcode, micro-printing, watermark, emboss etc. The main aim of this work is to provide information about security features present in Nepali passport so that concern agencies as well as general public to distinguish between genuine and fake passport.
ASSESSMENT OF THE CURRENT SITUATION OF SALINITY INTRUSION IN TAN PHU DONG AND GO CONG DONG DISTRICTS, TIEN GIANG PROVINCE AND PROPOSAL OF SOLUTIONS
Authors: Thanh Dat Tran , Huyen Trang Ngo Thi , Van Nam Thai
Published: January 2024

The research used statistical analysis methods, compared, and simulated the MIKE model, predicted the risk of salinity intrusion according to the scenarios RCP 4.5 and RCP 8.5 to assess the current situation of salinity intrusion and its impact on Go Cong Dong district and Tan Phu Dong district. After conducting the study “Assessing of the current situation of salinity intrusion in Tan Phu Dong and Go Cong Dong districts of Tien Giang province and proposing solutions”, the researchers achieved the following results: the situation of salinity intrusion in both 2 districts became more complicated, salinity intrusion came early, high salinity encroached the fields. In 2020, salinity intrusion came 1 month early, the highest salinity level reached 25.4 g/l; Regarding the risk prediction of salinity intrusion: according to the scenarios of RCP 4.5 and RCP 8.5 through the periods of 2030, 2050, 2070, 2100, the salinity level in the studied area tends to increase gradually, the lowest salinity will be from 4 to 6 g/l, the salinity in the whole districts of Tan Phu Dong and Go Cong Dong will exceed 12 g/l in 2100. Regarding the assessment of the impacts of salinity intrusion to the main local industries including agriculture – forestry – fishery, the fields of land, water, and ecosystem resources, the agriculture and water resources sectors are most severely affected.
CONSIDERATION OF DAMAGING FREQUENCY RANGES OF STRUCTURAL EXCITATION FOR TESTING LARGE BATTERY PACKS IN BATTERY ELECTRIC VEHICLES (BEV)
Authors: Plaumann Benedikt
Published: January 2024

Realistic vibration testing of large floor mounted Battery Pack, sometimes called Rechargeable Energy Storage Systems (RESS), for Batterie Electric Vehicles (BEV) is important for developing safe new battery structures. On the other hand, the requirements for realistic replications of worst-case environments in a lab usually demand costly and complex infrastructure. A key factor to the quality of environment replication and an important cost driver due to the increasing complexity is the needed frequency range the equipment must be able to replicate. The contribution analyzes data from a first pre-test campaign to demonstrate a feasible process of deriving frequency band requirements for the test equipment. The key method used here is the Fatigue Damage Spectrum (FDS) to analyze the potential damage a vibration could cause in certain failure mechanism of interest, particularly “weighted” by the corresponding double-logarithmic dependance of stress magnitude over occurring load cycles. This enables a good assessment of how much damage could be induced in certain frequency ranges for a well justified and cost-effective choice on the needed test equipment.
AN EXPLORATORY STUDY OF HOW EMOTION TONE PRESENTED IN A MESSAGE INFLUENCES ARTIFICIAL INTELLIGENCE (AI) POWERED RECOMMENDATION SYSTEM
Authors: Leong Kelvin , Sung Anna
Published: January 2024

This innovative study aims to explore how emotion tone presented in a message influences the judgement of Artificial Intelligence (AI) bots. We established a scenario by using vacation rental introduction as input message to conduct experiments to explore the influences. Our findings suggest that AI bots demonstrate preferences on the input message presented in positive tones rather than input message with negative tones. Our pioneering study can serve as a crucial starting point for future studies, in particular opening up fresh avenues for future research endeavours and engenders discussions and debates concerning the development of recommendation system.
RESPONSE OF DIFFERENT SEEDLING ESTABLISHMENT METHODS ON GROWTH AND YIELD OF RICE IN TERAI REGION OF NEPAL
Authors: Rai Khushubu , Kulung Oshna , Rana Mamta , Tamang Anita , Gaire Achyut
Published: January 2024

The experiment was conducted at Agronomy farm, Rampur Campus, Chitwan to evaluate the effect of seedlings establishment methods on growth and yield of main season rice, 2021. RCBD design was used with four replications and six treatments viz. T1- Farmers’ practice (random transplanting), T2- traditional transplanting (20cm*20cm), T3- System of Rice Intensification, T4- non-puddled transplanting, T5- wet DSR (broadcasting), and T6- wet DSR (line-sowing). The foundation seed of Ramdhan was used as a study material. Data were recorded on different growth, yield and yield attributing traits. ANOVA revealed statistically significant differences (p<0.05) for all parameters except number of effective tillers m-2, number of unfilled grains panicle-1 and sterility percentage. Lowest effective tillers m-2, biological yield, number of filled and total grains panicle-1 was observed in T6 resulting in lower grain yield (4.92 tonha-1). Highest thousand grains weight (23.18gm), grain yield (6.13 tonha-1), and harvest index (22.13%) were recorded in T3. The highest grain yield of T3 was followed by T2 (5.82tonha-1) at par with T1 (5.73tonha-1). The minimum sterility percentage was 30.49% in T4. Plant height at 120 DAS, number of tillers hill-1 120 DAS, number of leaves hill-1 105DAS, LAI 105DAS, panicle length and no. of filled grains panicle-1 expressed a positive correlation with grain yield. The regression value showed that the maximum variation in grain yield was governed by PH at 120DAS (62.37%), LAI at 105 DAS (61.85%), and panicle length (47.04%) primarily.
ECONOMICAL EVALUATION OF MANGO (CV. KEITT) TREES UNDER COLOURED SHADE NETS
Authors: Mohamed Assem A. A. , Abdrabbo Mohamed A. A. , Medany Mahmoued A. , Esmail A. A. M.
Published: January 2024

This study explored the economical viability of five different coloured shade nets (White, yellow, red, blue and black) on mango production (Mangifera indica L. cv. Keitt). This study investigated the climatic parameters in terms of light intensity, minimum and maximum air temperature, relative humidity and plant growth across 2019 and 2020 seasons. When compared to open field conditions, coloured shade nets resulted in higher maximum temperatures and relative humidity. The black net cover and open field treatments gave the lowest mango yield compared to all greenhouse net cover. When compared to the other treatments, the use of white or yellow nets resulted in a considerable increase in the number of fruits and total yield per plant. According to prevailed conditions, it could be concluded that optimum microclimate for growing mango in similar conditions could be obtained under white and yellow nets compared to the other net covers. Black greenhouse net cover gave the lowest productivity during the experimental duration. Production costs, total revenue, net return and ratio of total revenue to cost for Keitt mango in Egypt are presented in this study. The result shows that the net return for white net reached 15777 Egyptian pound (LE) and LE 15270 per m2 in 2019 and 2020 respectively, which was 2.63 times those grown in the open field (LE 5980 and LE 5081 per 2000 m2) in 2019 and 2020 respectively. However, Revenue to cost ratio was found higher in white net in both seasons which were 1.9 and 1.8 respectively.
INTEGRATED APPROACH FOR CLUBROOT MANAGEMENT IN COLE CROPS: A REVIEW
Authors: Parajuli Kushal
Published: January 2024

Clubroot is a severe cosmopolitan disease of cole crops. This disease is caused by Plasmodiophora brassicae which is a soil-borne pathogen. This disease is emerging as one of the biggest threats to cole crops. This pathogen was first detected in Europe. Several experiments have been conducted to understand the nature of the pathogen but the complexity of the pathogen is not properly understood yet. Due to this reason, the management of clubroot has been quite a challenge to the researchers. Given the lack of knowledge about the pathogen, farmers, and plant pathologists around the globe are struggling to control the disease. Integrated approaches are being introduced for better management of the disease. The integrated approach includes various physical, chemical, cultural, and biological methods that are combined to overcome the problem.
POLYPLOIDY BREEDING IN AGRICULTURE: AN OVERVIEW
Authors: Banjade Gaurave , Chaudhari Goma , Mahato Asmita , Uprety Shreesha
Published: January 2024

Polyploid is a condition where the chromosomes are more than complete sets. The chromosome sets can vary owing to both natural and man-made processes. In artificial process, the mostly used chemical is colchicine which a toxic alkaloid extracted from Colchicum autumnale which was first discovered in 1937. Polyploids helps to increase the size of the cells i.e., giggas. Despite being a technique for creating variance, it is not becoming more popular. This research examines several facets of polyploidy breeding by examining various published works. They outperform natural diploids in terms of high yield, resilience to biotic and abiotic factors, and having better vigor. Irregular fruits, higher percentage of water, sterility made the polyploidy application concentrated only to vegetatively propagated and seedless plants. Although using polyploidy in breeding programs is not a novel method, it is continuously being investigated for potential improvements.
A REVIEW ON PROPAGATION METHODS OF GRAPE (Vitis Vinifera L).
Authors: Thagunna Suraj Singh
Published: January 2024

This comprehensive literature review delves into the intricate world of grapevine (Vitis vinifera L.) propagation methods, exploring the historical context, various techniques, and their profound implications for viticulture. Spanning diverse climates globally, grapes are pivotal for wine production, fresh table grapes, and an array of by-products. The propagation methods, including cuttings, grafting, and in vitro techniques, significantly impact genetic diversity, disease resistance, and grape quality. The review underscores the necessity of considering environmental factors, disease resistance, and economic viability when selecting a propagation method, advocating for tailored approaches to local climates and soil conditions. The integration of genetic engineering, ongoing research, and technological advancements emerge as crucial elements shaping the future of grapevine propagation. Quality control in nurseries, economic considerations, and skill development in labour are emphasised for overall success. Real-world examples, such as the success at the Agro-Shtil Nursery in Israel, highlight the effectiveness of grafting, particularly due to its disease resistance, salt-tolerant rootstock selection, time efficiency, and cost-effectiveness. The review concludes with recommendations for collaborative knowledge sharing within the viticulture community, ensuring a holistic and informed approach to grapevine propagation for sustainable and high-quality grape cultivation. This literature review serves as a valuable guide for vineyard managers, researchers, and industry professionals navigating the complexities of grapevine propagation.
BANANA BLOSSOM: NUTRITIONAL VALUE, HEALTH BENEFITS AND ITS UTILIZATION
Authors: Thagunna Bishal
Published: January 2024

Bananas are an attractive and low-cost food supply for poor countries, where bananas are consumed by the majority of the population. Typically, only the fruit of the banana tree is consumed, and before the fruit is cooked, the banana heart is chopped out and thrown. However, many people are unaware that the banana heart, also known as the banana blossom, has a high nutritional content and numerous health benefits. The blossom of a banana contains a lot of fiber and can be used to make fiber-rich foods. In addition, the flower includes a variety of bioactive substances, such as alkaloids, tannins, flavonoids, and phenolic compounds, all of which have anti-cancer, anti-microbial, and antioxidant activities. This plant is often used as a food additive in many Asian countries. On the other hand, the banana flower has received only sporadic attention. As a result, the aim of this review is to evaluate the nutritionally dense compact pack of banana blossoms and highlight the value-added product fortified with banana blossoms. So, these unique nutritional values of banana blossom should get maximum utilization, and incorporation of this banana blossom in food products can be performed for value addition.
Pengaruh Pendidikan Kesehatan Cuci Tangan 6 Langkah Dengan Metode Demonstrasi Terhadap Sikap Hidup Sehat Siswa Kelas 5 SD Negeri Mokaha 01
Authors: Murfidyanto Dhiya , Febrianta Yudha
Published: January 2024

Cuci tangan merupakan hal sepele yang harus didasari sejak dini karena anak pada usia tersebut termasuk anak yang kritis terhadap penyakit. Maka sikap hidup sehat perlu ditanamkan agar menjadi kebiasaan yang baik bagi siswa. Penelitian ini bertujuan untuk mengetahui pengaruh pendidikan kesehatan cuci tangan 6 langkah dengan metode demonstrasi terhadap sikap hidup sehat siswa kelas 5 di SD N Mokaha 01. Metode penelitian ini merupakan penelitian kuantitatif dengan menggunakan rancangan pre test dan post test, populasi pada penelitian ini adalah seluruh siswa kelas 5 SD N Mokaha 01 dengan teknik pengambilan sampel yaitu total sampling dengan jumlah responden 30. Analisis data yang digunakan yaitu menggunakan uji statistic statistik Paired Sample T-test. Hasil pre test menunjukkan siswa mayoritas cukup sebanyak 26 siswa (86,8%) dan post test menunjukkan siswa mayoritas baik 21 siswa (69,9) dengan nilai Sig = 0.000. Simpulan yang didapat pada penelitian ini adalah bahwa ada pengaruh pendidikan kesehatan cuci tangan 6 langkah dengan metode demonstrasi terhadap sikap hidup sehat siswa kelas 5 di SD N Mokaha 01 dengan nilai Sig = 0.000.
Analisis Implementasi Kurikulum Merdeka Belajar Dalam Pembelajaran PJOK di SDN Sidareja 01
Authors: Fahmi Prasetio Nugroho  , Yudha Febrianta
Published: January 2024

Penelitian ini bertujuan untuk menerapkan penerapan Kurikulum Merdeka Belajar dalam pembelajaran PJOK di SDN Sidareja 01. Penelitian ini menggunakan jenis penelitian kualitatif deskriptif. Penelitian ini menggunakan teknik pengumpulan data observasi, wawancara, dan studi dokumentasi. Subjek Penelitian ini yaitu Guru PJOK, Kepala Sekolah, dan Siswa kelas V. Hasil penelitian yaitu Penerapan Kurikulum Merdeka Belajar dalam pembelajaran PJOK di SDN Sidareja 01 sudah ada yang sesuai dengan Kurikulum Merdeka Belajar dan ada juga yang belum sesuai dengan Kurikulum Merdeka Belajar. Hal yang sudah sesuai yaitu keselarasan Struktur Kurikulum Merdeka Belajar, asesmen, dan terdapat buku panduan siswa dan guru Kurikulum Merdeka Belajar. Hal yang belum sesuai yaitu belum adanya modul terbuka, Alur Tujuan Pembelejaran (ATP), modul P5, serta belum melakukan pembelajaran dengan pendekatan Teaching at The Right Level (TaRL) dan diferensiasi. Faktor pendukung dari penerapan Kurikulum Merdeka Belajar di SDN Sidareja 01 yaitu Kepala Sekolah selalu memberikan berita up to date kepada tenaga pendidik terkait sosialisasi Kurikulum Merdeka belajar kepada tenaga pendidik serta terdapatnya calon guru penggerak yang dapat memberikan wawasan baru Kurikulum Merdeka Belajar kepada guru PJOK. Faktor penghambat penerapan Kurikulum Merdeka Belajar pada Pembelajaran PJOK adalah belum adanya sosialisasi Kurikulum Merdeka Belajar Khusus Guru PJOK di Kecamatan Sidareja.
Enhancer mutations modulate the severity of chemotherapy-induced myelosuppression
Authors: Zhigulev Artemy , Norberg Zandra , Cordier Julie , Spalinskas Rapolas , Bassereh Hassan , Björn Niclas , Pradhananga Sailendra , Gréen Henrik , Sahlén Pelin
Published: January 2024

Non-small cell lung cancer is often diagnosed at advanced stages, and many patients are still treated with classical chemotherapy. The unselective nature of chemotherapy often results in severe myelosuppression. Previous studies showed that protein-coding mutations could not fully explain the predisposition to myelosuppression. Here, we investigate the possible role of enhancer mutations in myelosuppression susceptibility. We produced transcriptome and promoter-interaction maps (using HiCap) of three blood stem-like cell lines treated with carboplatin or gemcitabine. Taking advantage of publicly available enhancer datasets, we validated HiCap results in silico and in living cells using epigenetic CRISPR technology. We also developed a network approach for interactome analysis and detection of differentially interacting genes. Differential interaction analysis provided additional information on relevant genes and pathways for myelosuppression compared with differential gene expression analysis at the bulk level. Moreover, we showed that enhancers of differentially interacting genes are highly enriched for variants associated with differing levels of myelosuppression. Altogether, our work represents a prominent example of integrative transcriptome and gene regulatory datasets analysis for the functional annotation of noncoding mutations.
The origin, evolution, and molecular diversity of the chemokine system
Authors: Aleotti Alessandra , Goulty Matthew , Lewis Clifton , Giorgini Flaviano , Feuda Roberto
Published: January 2024

Chemokine signalling performs key functions in cell migration via chemoattraction, such as attracting leukocytes to the site of infection during host defence. The system consists of a ligand, the chemokine, usually secreted outside the cell, and a chemokine receptor on the surface of a target cell that recognises the ligand. Several noncanonical components interact with the system. These include a variety of molecules that usually share some degree of sequence similarity with canonical components and, in some cases, are known to bind to canonical components and/or to modulate cell migration. Whereas canonical components have been described in vertebrate lineages, the distribution of the noncanonical components is less clear. Uncertainty over the relationships between canonical and noncanonical components hampers our understanding of the evolution of the system. We used phylogenetic methods, including gene–tree to species–tree reconciliation, to untangle the relationships between canonical and noncanonical components, identify gene duplication events, and clarify the origin of the system. We found that unrelated ligand groups independently evolved chemokine-like functions. We found noncanonical ligands outside vertebrates, such as TAFA “chemokines” found in urochordates. In contrast, all receptor groups are vertebrate-specific and all—except ACKR1—originated from a common ancestor in early vertebrates. Both ligand and receptor copy numbers expanded through gene duplication events at the base of jawed vertebrates, with subsequent waves of innovation occurring in bony fish and mammals.
Konsep Jihad Syeikh Muhammad Ilyas Al-Kandahlawi Dalam Tradisi Khuruj Fii Sabilillah Jama’ah Tabligh Di India
Authors: Lia Nik Amul Lia
Published: January 2024

Jihad merupakan bagian dari usaha dakwah yang membutuhkan pengorbanan tinggi baik berupa pengorbanan jiwa, raga maupun harta untuk dapat menegakkan agama dimuka bumi ini. Namun seiring terjadinya aksi teror yang dilakukan oleh sekelompok golongan tertentu membuat konsep jihad sering diidentikkan dengan qital (bunuh), harb (perang, war) bahkan irhab (terorisme). Tetapi dalam usaha dakwah untuk menumbuhkan kembali agama Islam dihati masyarakat India terutama Mewat, Syeikh Ilyas memiliki cara yang unik dengan membuat gerakan dakwah khuruj fii sabilillah. Dari gerakan dakwah ini, Syeikh Ilyas telah memberikan wajah baru dalam konsep jihad untuk membawa perubahan didalam kehidupan beragama masyarakat Mewat. Penelitian ini memiliki tujuan untuk mengetahui konsep jihad Syeikh Muhammad Ilyas Al-Kandahlawi dalam tradisi khuruj fii sabilillah jama’ah tabligh di India. Metode penelitian yang digunakan adalah kualitatif-library research dengan pendekatan historis atau heuristik serta menggunakan jenis penelitian life story. Hasil penelitiannya adalah terdapat lima konsep jihad dalam tradisi khuruj fii sabilillah yakni Pertama, jihad dalam perjuangan batin untuk menundukkan elemen dasar jiwa perseorangan jama’ah yang merupakan sebuah refleksi perjuangan untuk menundukkan elemen dasar jiwa masyarakat India agar mau meninggalkan perbuatan maksiat dan perjuangan tersebut tanpa dilakukan atau melalui jalan kekerasan atau anarkis. Kedua, jihad untuk menumbuhkan keyakinan akan ganjaran yang didapat dari janji Allah bagi umat muslim yang keluar dijalan Allah SWT, pergi dari satu tempat ketempat lain untuk menghidupkan kembali agama yang dibawa oleh Rasulullah SAW yakni Islam kedalam hati masyarakat India terutama yang ada di Mewat dan sekitarnya. Ketiga, jihad dengan mengorbankan jiwa, raga dan harta benda demi kepentingan gerakan dakwah khuruj fii sabilillah. Keempat, jihad untuk melatih kesabaran para jama’ah dalam menghadapi segala bentuk fitnah, cemoohan maupun diperlakukan tidak baik selama berdakwah di India, dan Terakhir yakni jihad untuk melawan kebodohan.
Generation Z Media Literacy Awareness of the Rainbow Symbol on Tik-tok as an LGBT Campaign
Authors: Ayu Mujiyanti  , Vyki Mazaya
Published: January 2024

Tik-tok is a social media that has been present in Indonesia since 2018 and was blocked by the Ministry of Communication and Information for one week because it gave negative broadcasts. However, Tik-tok has now spread as a medium for campaigning for various aspects, one of which is the LGBT (lesbian, gay, bisexual and transgender) is a term for people who have deviations in their sexual orientation and are synonymous with the rainbow flag and rainbow symbol. LGBT with rainbow symbol on Tik-tok. The formulation of the problem discussed was regarding how to use the rainbow symbol on Tik-tok as an LGBT campaign and how media literacy awareness of Generation Z on LGBT campaigns in using the rainbow symbol on Tik-tok (Studies on Islamic Communication and Broadcasting Students of UIN KH. Abdurrahman Wahid Pekalongan. The type of research used is qualitative, with data collection techniques of observation, interviews, and documentation. Data analysis used by researchers is using the method from Miles and Huberman, which includes the process of data reduction, data presentation, and drawing conclusions. The results of research on rainbow symbols in some content on Tik-tok are a campaign for LGBT actors in the world, including Indonesia. Although there are two possible uses of the rainbow symbol as something related to aesthetic elements. The results of the analysis of Z generation's media literacy awareness of LGBT campaigns in using the rainbow symbol on Tik-tok (Study on Islamic Communication and Broadcasting Students of UIN K.H. Abdurrahman Wahid Pekalongan) are still not met, namely there are four New Media Literacy frameworks, namely the consumption function includes consuming skills and understanding, critical consumption includes analysis, synthesis, and evaluation, participation functions include prosuming skills and distribution, as well as critical participation.