bluuebunny/crossref_metadata_2025 huggingface dataset:
Fractographical Characterization of Jute Fibre Reinforced Paper Composite Subjected to Drop Test
Authors: Makhatha Mamookho Elizabeth , Kumar Pawan
Published: October 2023

Plastic bags are one of the most widely used packaging materials in industries. Lower production cost, lightweight and high strength envisage its use in food packaging, carrier, and transportation industries. However, these plastic bags are non-biodegradable and cause serious water and soil pollution. It is one of the most thrust areas of research to overcome this problem in the current world. In the present investigation, fabrication, and characterization of an environmentally friendly and biodegradable "jute fibre reinforced paper composite" and "reinforcement free paper laminate" subjected to drop test were done. The standard procedure of the "MIL-STD-810G 516.6" drop test was followed. The adhesion between the matrix (paper) and reinforcement (jute fibre) was produced by applying a chemical-free adhesive made of flour and water. There were four different types of samples: single paper (SP), reinforcement-free paper laminate (RFPL), single-layer jute fibre reinforced paper composite (SLJPC), and double-layer jute fibre reinforcement paper composite (DLJPC). The microstructural characterization of the fractured surface after the drop was done using a scanning electron microscope operated at a voltage of 20 kV. The DLJPC samples had the maximum density and envisage drop-strength of 7 times as compared to the SP samples having the lowest density. The drop-strength exhibited linear regression with density for all the samples. The microstructure of the as-received matrix showed a non-homogeneous distribution of fibres along with micro-voids which were susceptible sites for the fracture. Unlike as-received matrix fibres distribution, the reinforcement fibres were aligned in two mutually perpendicular directions which leads to its strengthening. Hence, it can be said that the non-uniform structural properties envisaged by the as-received matrix can be compensated by uniformly distributed structural properties of the as-received reinforcement when both come together as a composite. The primary fracture mechanism of SP samples exhibited fibre breaking along with a few fibres' delamination. However, in the case of the RFPL sample, the nature of adhesion applied was capable to hold both the interfaces and the primary fracture mechanism was fibre breaking. It is suggested that the adhesive applied transmitted load through the interfaces. Unlike SP sample, the RFPL sample exhibited some adhesive pull-off. The fractured surface of the SLJPC sample showed that the matrix did not subject to fracture, however, reinforcement did fracture hence the load was transferred from matrix to reinforcement followed by a rupture of the reinforcement. Therefore, the primary fracture mechanism for the SLJPC sample was reinforcement rupture. The DLJPC sample showed a delamination of matrix and reinforcement.
Development and Characterization of Green Composites from Agro Waste Aloe Vera and Pineapple Leaf Fiber
Authors: Kumar Ajay , Singh Abhishek
Published: October 2023

Natural fibers possess the advantage of low cost, abundant in quantity and biodegradability. Rising awareness about green products and supportive government regulations are likely to propel the growth in the field of green composite. In this current research, a comparative study of mechanical characteristics and water absorption behaviour of green composites incorporating Aloe Vera and pineapple leaf fibers in biodegradable matrix (polylactic acid) has been experimentally examined. Composite has been developed using compression molding technique. The effect of surface modification of fibers on mechanical properties and water absorption behaviour of developed composite was investigated. Surface treatment was done using alkaline solution of sodium hydroxide having concentration of 5%. Treatment of fiber enhanced tensile, flexural, microhardness and impact properties of developed green composite and reduces water absorption capacity. Moreover, experimental results show that Aloe Vera reinforced composites have better mechanical properties in comparison to Pineapple leaf fiber reinforced composites. Thereby having potential to be used in various engineering applications
The Rigler’s triad: a case of gallstone ileus
Authors: Montori Giulia , Procida Giuseppa , Dal Borgo Andrea , Licitra Edelweiss , Gobbi Tobia , Fappiano Francesca , Salemi Federica , Agresta Ferdinando
Published: October 2023

Rigler’s triad is an extremely rare syndrome that accounts for 4% of all cases of small intestinal obstruction (SBO). This illness is distinguished by three clinical and radiological features: pneumobilia, a severe intestinal blockage, and an abnormally placed gallstone in the gallbladder. An 84-year-old woman arrives at the Emergency Department with symptoms of SBO. The CT scan is essential for detecting the trio. An emergency laparoscopy with an enterotomy and gallstone extraction was conducted successfully. The Rigler’s triad should be suspected in elderly individuals with a history of gallstones in the gallbladder, especially in the emergency scenario. Large and solitary gallstones in the gallbladder that are asymptomatic should be candidates for cholecystectomy. In conclusion, this case is a very didactic instance, particularly because of the crisp CT images that can assist surgeons in identifying gallstone ileus and the mini-invasive method that can also benefit in an emergency context.
Bibliometric study on scientific productivity in the use of smart bracelets
Authors: Sulla-Torres Jose , Vidal-Espinoza Rubén , Avendaño Llanque Christopher , Calla Gamboa Alexander , Zúñiga Carnero Manuel , Cossio-Bolaños Marco , Gomez-Campos Rossana
Published: October 2023

In recent years, wearable sensors and mHealth applications are becoming an important part for recording and monitoring health parameters. The aim is to characterize bibli-ometric indicators on scientific productivity in the use of smart bracelets according to scientific journal, study topic and publication trend. A bibliometric study was per-formed. The data extracted from the articles were: year of publication, name of the journal, language of publication, country, type of study and subject matter. A total of 45 studies were identified (21 cross-sectional and 24 experimental), of which 43 were published in English, one in Spanish and one in German. A total of 32 scientific journals published eight research topics related to smartwatch use [active living with 17 studies (37.8%), followed by stress and anxiety with 7 studies (15.6%), nanogenerators (batteries) with 6 studies (13.3%), computing with 5 studies (11.1%), chronic diseases 4 studies (8.9%), COVID propagation 3 studies (6.7%), energy expenditure 2 studies (4.4%) and occupational health 1 study (2.2%)]. The journal Sensors (Basel) published the most articles in the last 6 years (n=7, 16%). The scientific productivity of both study types reflects a positive trend (cross-sectional studies R2= 0.82 and in experimental studies R2= 0.76). A total of 45 cross-sectional and experimental studies using smart-watches were verified in eight different study topics. The most investigated category was active living and the journal that published the highest number of articles was the journal Sensors (Basel).
The troubled course of the CHIVA Cure through clinical studies: a critical review
Authors: Cappelli Massimo , Molino Lova Raffaele , Pinelli Mauro , Franceschi Claude
Published: October 2023

The treatment of Superficial Venous Insufficiency (SVI) encompasses a wide and disparate array of techniques, ranging from destructive procedures (endovascular ablation, stripping and sclerotherapy) to the conservative hemodynamic procedure (CHIVA). This variety of options betrays a wide degree of uncertainty on the recommended treatment, mainly due to technical biases in performing the CHIVA Cure that heavily affect the results from Randomized Controlled Trials (RCTs). In fact, the authors of the last Cochrane Review (CR) on the CHIVA Cure disowned its superiority based on the results from five RCTs in which more than 200 of the overall 419 participants allocated to the CHIVA arm had actually received treatments other than the CHIVA Cure. Further, the Guidelines (GLs) from both the American and the European Society for Vascular Surgery recommend the CHIVA Cure only to vascular surgeons experienced with this technique, contradicting what is expected of a specialist, i.e. mastery of the treatment of diseases in his or her specialty. Finally, CRs and GLs do not take into any account the ethically relevant issue that destructive procedures, recommended for vascular surgeons not experienced in the CHIVA Cure, will fatally deprive the patient of the Great Saphenous Vein (GSV), which is the first-choice infra-inguinal graft for the treatment of severe peripheral artery disease and to ward off the severely disabling condition resulting from limb loss, when angioplasty/stenting is not feasible. In this paper we review and discuss the RCTs, CRs, and GLs concerning the CHIVA Cure available at June 2023 on Medline and Cochrane Central databases.
Short-term Clinical Outcomes of Ticagrelor versus Clopidogrel after Percutaneous Coronary Intervention in Patients with Myocardial Infarction: A Randomized Clinical Trial Study
Authors: Nikfarjam Salman , Borghei Yasaman , Salari Arsalan , Miraftabi Seyyed Mehrad , Gholami-Chaboki Bahare , Fakhr-Moosavi Seyyed Aboozar
Published: October 2023

Background:

Reperfusion can be done through primary percutaneous coronary intervention (PPCI) and thrombolytic administration. Patients with myocardial infarction should receive antiplatelet drugs from the P2Y12 receptor inhibitor category (such as ticagrelor, prasugrel, and clopidogrel). Based on recent researches, effectiveness of ticagrelor versus clopidogrel is still debatable.

Methods:

A total of 128 patients who underwent PPCI, divided into two groups (Zyllt® group (600 mg received as a loading dose, maintenance with dose of 75 mg daily)) and Ticora® group (180 mg as a loading dose, maintenance with dose of 90 mg twice). Both the groups received aspirin 80 mg daily, too. They were followed up after 3 months.

Results:

In this study, 86.9% were men, and there was no significant difference in terms of gender and age in 2 groups. Risk factors, type of myocardial infraction (MI), number of involved and infarct-related arteries, and presence of complications and their type were not statistically different in groups (P > 0.05). Among all complications, only one person had dyspnea in the Ticora group, one patient in the Ticora group, and 3 patients in the Zyllt group had chest pain. The difference in “TIMI Score” during Time was significant (P = 0.037).

Conclusion:

Our study shows no difference between ticagrelor and clopidogrel after PPCI in patients with MI in terms of risk factors, type of MI, number of involved and infarct-related arteries, and presence of complications and their type, in two studied groups.
Predictions of Adherence to Treatment in Patients Referred to the Heart Failure Clinic of Shahid Rajaee Hospital in Tehran
Authors: Shojaee Asma , Azimi Amir Vahedian , Naderi Nasim , Salaree Mohammad Mehdi , Faizi Fakhrudin
Published: October 2023

Background:

The objective of this study was to identify the level of treatment adherence and also sought to explore several demographic, clinical, comorbidities, and self-care behavior factors that may affect adherence among patients with heart failure (HF).

Materials and Methods:

This single-center cross-sectional, questionnaire-based study was conducted on 500 adult HF patients referred to the clinic of Rajaie Cardiovascular, Medical, and Research Center, in Tehran, Iran, from February to July 2022. The level of treatment adherence was assessment through Modanloo’s questionnaire. An unadjusted and adjusted binary logistic regression model was used to check the effect of different factors on the patients’ adherence level.

Results:

Among 474 responders, 51.7% had “good” adherence to treatment. According to the results, age >54 years (odds ratio [OR]: 0.967, 95% confidence interval [CI]: 0.946–0.988, P = 0.002), mitral valve regurgitation (OR: 0.597, 95% CI: 0.362–0.982, P = 0.042) and HF duration (OR: 0.486, 95% CI: 0.274–0.862, P = 0.014) were found as independent variables associated with “poor” treatment adherence. However, higher educational level (OR: 3.313, 95% CI: 2.632–4.067, P < 0.001), New York Heart Association class I (OR: 3.231, 95% CI: 1.587–4.661, P = 0.002), ejection fraction (EF) >40% (OR: 1.023, 95% CI: 1.005–1.041, P = 0.013), HF with preserved EF (OR: 2.728, 95% CI: 1.387–5.365, P = 0.004), familiar with social media (OR: 3.792, 95% CI: 1.777–4.268, P < 0.001) and high awareness of HF (OR: 2.385, 95% CI: 1.072–3.044, P = 0.006) were significant positive predictors for good adherence to treatment.

Conclusion:

Adherence to the treatment regimen has improved compared to previous studies, but is still suboptimal, particularly with respect to awareness of HF. Therefore, improving the awareness of patients as well as encouraging and supporting them for self-care behaviors can have a positive effect on treatment adherence.
Establishment of a Two-stage Limb Ischemia in Diabetic Rats
Authors: Cao Yu , Hu Shuyu , Wang Hongbo , Li Xiaoyao , Ma Jun , Wang Liangrong
Published: October 2023

Background:

This study aimed to establish a clinically relevant animal model for peripheral arterial disease (PAD) that better replicates the complexity observed in human patients.

Materials and Methods:

Thirty male rats were randomly assigned into the sham (SM), femoral artery resection (FE), constrictor-induced ischemia (CI), two-stage ischemia (TS), or diabetic two-stage ischemia (DT) groups. In the FE group, rats underwent femoral artery resection, whereas the SM group had sham surgery. The CI group received progressive ischemia using two ameroid constrictors, and the TS and DT groups underwent a two-stage ischemia procedure involving initial gradual narrowing with two ameroid constrictors and subsequent femoral artery resection in healthy and diabetic rats, respectively. Perfusion evaluation and functional assessment were conducted at postoperative days 14, 28, and 42. On day 42, hypoxia-inducible factor (HIF)-1α and vascular endothelial growth factor (VEGF) protein expression were measured, along with histological examination and immunofluorescence analysis.

Results:

Motor function deficits and reduced limb reperfusion were most prominent in the TS and DT groups on days 28 and 42 (P < 0.05), exacerbated by type 2 diabetes. Gastrocnemius exhibited upregulated HIF-1α and VEGF protein expression, as well as increased capillary density in response to ischemia. However, the DT group showed significantly lower protein expression and capillary density, along with more severe structural damage compared to other groups (P < 0.05).

Conclusion:

A clinically relevant rat model of PAD was established by implementing a two-stage ischemia procedure involving initial progressive narrowing and subsequent femoral artery excision in the context of diabetes.
Social Adjustment, a Necessity among Students with Negative Body-Image: The Roles of Parenting Processes and Self Esteem
Authors: Omoponle Adewuyi Habeeb
Published: October 2023

The social adjustment strategy in interacting with others determines an individual's success. This study examined the influence of parenting processes and self-esteem as correlates of social adjustment of students with negative body-image. The descriptive research design of the correlational type was used in this study. A total of 96 adolescents with negative body image participated in the study (42.7% male, 57.3% female). The data for this study were gathered using three reliable and standardized instruments: The Parenting Behavior and Dimension Questionnaire (α = .87), the Self-Esteem Inventory (α = .85), and the Social adjustment scale (α = .83). The results demonstrated a strong correlation between parenting processes (r = .201; p<.05), self-esteem (r = .211; p<.05) and social adjustment of students with negative body-image. The strongest predictor of social adjustment was self-esteem (β = .153; t = 1.377; p<0.05), followed by parenting process (β = .136; t = 1.228; p<0.05). It was recommended that educators, counselors, and all other helping professionals be alert and sensitive to the social dispositions of adolescents.
Optimisation of seed oil and powder of Momordica charantia in the formulation of body scrub cream
Authors: Winarti Lina , Dzakkiyah Shifwatu , Irawan Eka Deddy , Narulita Erlia
Published: October 2023

Background: Momordica charantia seed oil and powder are potential ingredients for a body scrub. The seeds contain fatty acids to moisturise the skin, and the mineral content to remove dead skin cells and nourish the skin.   
Objective: To determine the optimal efficiency of Momordica charantia seed oil and powder on body scrub cream produce.   
Methods: The body scrub used W/O (water-in-Oil) cream base. Simplex Lattice Design was used to determine five formulas. The irritation test with the Draize Skin Test method was carried out on rats (n = three, in each formula), and the Primary Dermal Irritation Index (PDII) was calculated. Informed consent from the female participants has been obtained for the hedonic test.    
Results: The body scrub cream produced appropriate organoleptic, was not irritating, and was stable after centrifugation and cycling test. The optimum formula contained five grams of oil and one gram of powder with a pH of 5.21; viscosity of 205.33 dPa.s; spreading of 6.12cm; adhesion time of 19.86 seconds; rate of washing of 20.60 seconds; a colour value of 4.04; scent value of 2.90; and texture value of 2.98.   
Conclusion: The optimised body scrub cream yielded a good formula which can be developed as a body scrub preparation.
The optimisation and standardisation of Indonesian house dust mites allergenic extract as a desensitising agent
Authors: Pratama Yusuf Alif , Marhaeny Honey Dzikri , Kasatu Salsabilla Madudari , Rohmah Lutfiatur , Nurhan Ahmad Dzulfikri , Rahmadi Mahardian , Khotib Junaidi
Published: October 2023

Background: The different sequences of the allergen protease can induce different immunogenicity for the development of immunotherapy. Dermatophagoides pteronyssinus that has Der p1 as major protein will be developed as local allergen to be immunotherapy for treating rhinitis allergy.
Objective: This study aims to optimize and standardize the local Indonesian House Dust Mites Allergenic Extract from the harvesting into the extraction process.
Method: The harvesting media used is corn flour placed in certain conditions to produce the mites. After harvesting the flour in different weeks, the flour was extracted and the lipid content and Der p1 assay were measured.
Result: The result of the study is that the 3 weeks-harvesting time came higher for those parameters than the other harvesting time (p < 0.05).
Conclusion: Thus, it was concluded that the standardized harvesting and extraction process had been developed to produce the standardised Indonesian House Dust Mites Allergenic Extract.
The impact of mHealth application on improving medication adherence and hypertension management: A systematic review of randomised trials
Authors: Susanto Yugo , Pristianty Liza , Hermansyah Andi
Published: October 2023

Background: The mobile health (mHealth) application has been used for treating hypertension. However, its effectiveness in enhancing adherence and clinical outcomes in hypertensive patients remains limited.  
Objective: This study aimed to determine the impact of mHealth apps on medication adherence and reduced blood pressure among hypertensive patients.  
Method: A systematic review of randomised controlled trials published in Scopus, PubMed, and ScienceDirect from 2008 to 2022 was conducted. Bibliographies of eligible articles were further reviewed.   
Result: A total of 289 articles were identified, and 24 articles were qualified for inclusion. The mHealth apps improved either medication adherence or reduced blood pressure in seven studies (29%). Eleven studies (46%) showed that it could both increase medication adherence and lower blood pressure significantly. Six studies (25%) reported no improvement in both outcomes.
Conclusion: There is a piece of evidence that mHealth apps can improve medication adherence and accordingly reduce blood pressure.
Characteristics and communication skills of health professionals in implementing provider-initiated HIV testing and counselling (PITC) for Indonesian pregnant women
Authors: Hikmah Faiqatul , Notobroto Hari Basuki , Devy Shrimarti Rukmini , Triyono Erwin Astha
Published: October 2023

Background: HIV testing for pregnant women is an important test during pregnancy. HIV testing for pregnant women is a way to prevent mother-to-child HIV transmission.   
Objectives: To investigate the relationship between the characteristics and communication skills of health professionals while conducting provider-initiated HIV testing and counselling (PITC) for pregnant women.
Methods: This was an observational study with a cross-sectional approach. The study was conducted at 23 public health centres with 80 health professionals who conduct PITC. The data was analysed using the Chi-Square test.     
Results: There was a correlation between the characteristics and communication skills of respondents. Relationships were observed between respondents trained on PITC and communication with patients during PITC sessions (p=0.002); work experience and non-verbal communication skills (p=0.047), and type of profession of respondents and non-verbal communication skills (p=0.029).   
Conclusions: Communication skills had a relationship with experienced training on PITC, work experience, and type of profession. Increasing the communication skill of health professionals through work experience and training or education to improve the ability of health professionals in PITC services.
Therapy pattern of bronchodilators in chronic obstructive pulmonary disease (COPD) patients with acute exacerbations
Authors: Samirah Samirah , Aryani Toetik , Puspitasari Arina Dery , Ibrahim Marisa Anggia , Lutfiyah Bunga Izzatul , Rasyid Alfian Nur
Published: October 2023

Background:  Acute exacerbation of chronic obstructive pulmonary disease (COPD) is a worsening condition of acute respiratory symptoms caused by microbial infection, increased air pollution, and fatigue.    
Objective: This study determines the pattern of bronchodilators in patients with acute exacerbations of COPD.    
Method: This study was observational, using the health medical records of patients with COPD at the Universitas Airlangga Hospital, Surabaya. It was conducted between January-December 2019 on male patients who received bronchodilator therapy until discharge and were from age 40 and older.    
Result: A total of 48 patients met the inclusion criteria. The most commonly used bronchodilator therapy for inpatients was the combination of ipratropium bromide/salbutamol sulfate 0.5 mg/2.5 mg through inhalation in 63.64%. The most frequently used bronchodilator for discharge was salbutamol sulfate 2-4 mg orally in 87.50%.    
Conclusion: Therapy for acute exacerbation of COPD using a combination of ipratropium bromide/salbutamol sulfate as a preventive therapy is in line with the GOLD guidelines.
Carbomer and ethyl cellulose optimisation in the preparation of mucoadhesive microspheres ciprofloxacin hydrochloride
Authors: Sari Lusia Oktora Ruma Kumala , Fardliana Lintang Qonita , Nurahmanto Dwi , Irawan Eka Deddy
Published: October 2023

Background: Ciprofloxacin hydrochloride (CH) is an antibiotic used to treat urinary tract infections. CH has a short half-life and low bioavailability. Microspheres combined with a mucoadhesive system can increase the residence time of the drug in the stomach to increase the bioavailability of CH.     
Objective: This research was conducted to obtain the best amount of carbomer as a polymer mucoadhesive and ethyl cellulose as a matrix polymer based on factorial design.     
Method: The factorial design 22 was used to determine the amount of carbomer and ethyl cellulose to produce optimum mucoadhesive microspheres. Three responses were observed in this study: particle size, entrapment efficiency, and mucoadhesive strength.     
Result: The resulting entrapment efficiency was 69.0%, particle size was 404.52 nm, and mucoadhesive strength was 64.3 grams, with drug loading and yield values of 19.13% and 99.8%, respectively.     
Conclusion: The optimum formula with the highest response value is the formula containing 300 mg carbomer and 1000 mg ethyl cellulose.
Treatment success and related factors of drug-susceptible and drug-resistant tuberculosis patients in Aceh referral hospital
Authors: Maulina Novi , Zinatul Hayati  , Zulkarnain  , Kartini Hasballah  , Ika Waraztuty
Published: October 2023

Background: Tuberculosis (TB) remains one of the top ten causes of mortality worldwide. It is caused by a single infectious agent, Mycobacterium tuberculosis. Indonesia has the second highest cases globally and has a high burden of rifampicin-resistant (RR-TB). Xpert MTB/RIF has been used as a frontline test to detect RR-TB to improve treatment efficacy.
Objective: This study aims to summarise the bacteriologic conversion rate as the patient’s cured hallmark and related factors among adults confirmed to have pulmonary tuberculosis in a referral hospital in Aceh Province.
Method: The authors assessed 1,244 bacteriologic test results of sputum samples from TB presumptive patients from January 1st to December 31st 2018, in the Clinical Microbiology Laboratory and evaluated bacteriologic conversion.
Result: There were 361 bacteriologic-confirmed TB diagnoses, where 43 (11.9%) were RR-TB. Most TB patients (26.3%) were in close contact with active TB patients.
Conclusion: The study showed TB patients' low follow-up rate and bacteriologic conversion. The high prevalence of TB among close contacts suggests a need for constant surveillance of this high-risk group to end the TB epidemic. Male, young adult, and Aceh Besar residents have observed factors in sputum conversion results.
Pharmacists' perception about design and content of medicine labels on prescription services in community pharmacies
Authors: Mufarrihah  , Yaniar Nur Hidayah  , Arie Sulistyarini  , Ana Yuda
Published: October 2023

Background: Differences in perception among pharmacists and the absence of standards or regulations for labelling prescribed medicines in Indonesia make the labels patients receive have different designs and contents. Incomplete information and insufficient medicine label design can lead to medication errors.
Objective: This study aimed to determine the pharmacists’ perception of the design and content of prescribed medicine labels.
Method: This study was conducted by survey using an online questionnaire developed based on the "FIP Guidelines for The Labels of Prescribed Medicines" and Regulation of the Minister of Health of the Republic of Indonesia number. 73 the year 2016 concerning Pharmaceutical Service Standards in Pharmacies. Questionnaires were distributed through personal chat and social media groups of community pharmacists.
Result: A total of 925 pharmacists from 32 provinces of Indonesia participated in this study. Respondents considered the most important information on the label of prescribed drugs  namely instructions for drug use (84.6%), patient name (81.6%), pharmacy name (76.1%), special instructions (71.5%), and pharmacist name (63.9%). For the label’s design, most respondents preferred printed and handwritten labels (61.2%).
Conclusion: It can be concluded that different pharmacists' perceptions affect the labelling of prescribed medicines. There is a need for regulations or standards of labelling prescribed medicines.
A inclusão social de deficientes físicos e mentais nas aulas de Educação Física
Authors: Araújo Silvano Ferreira de , Ramos Wanessa Pucciariello , Piel João Lucas Pinheiro
Published: October 2023

A Educação Física é componente curricular que muito contribui para a formação dos alunos. Por meio dos seus conteúdos, faz com que os indivíduos tenham atitudes e sejam motivados a práticas saudáveis por meio do estímulo da percepção corporal, levando-os a adquirirem uma visão positiva sobre a cultura corporal do movimento. As aulas de Educação Física proporcionam elementos para que os alunos adquiram hábitos de vida mais saudáveis, além de apresentarem possibilidades de atividades para que crianças e jovens possam escolher, de forma autônoma, aquelas que mais gostam e melhor se adequem às suas possibilidades físicas. O objetivo deste trabalho é compreender como professores de escolas da Rede Pública e da Rede Privada do município de Ponta Porã, Mato Grosso do Sul, vivenciam a inclusão social de deficientes físicos e mentais nas aulas de Educação Física. A abordagem da pesquisa foi de caráter qualitativo, de natureza descritiva. Ao todo, participaram da pesquisa três professores do sexo masculino. Como instrumento de coleta de dados aplicou-se um questionário contendo cinco questões dissertativas. Os resultados demonstraram que os professores receberam uma formação mínima para trabalhar com alunos com deficiências físicas e mentais, mas que ainda assim lhes permitem adotar metodologias didáticas com vistas à sua inclusão, bem como promover melhoria na socialização desses indivíduos.
Benzene and water – different or similar?
Authors:   Innovation Center of the Faculty of Chemistry in Belgrade, Serbia, Milovanovic Milan R. , Zivković Jelena M. ,   Innovation Center of the Faculty of Chemistry in Belgrade, Serbia, Ninković Dragan B. ,   Innovation Center of the Faculty of Chemistry in Belgrade, Serbia, Blagojević Jelena P. ,   Innovation Center of the Faculty of Chemistry in Belgrade, Serbia, Zarić Snežana D. ,   University of Belgrade, Faculty of Chemistry, Serbia
Published: October 2023

Considering the properties of water and benzene molecules, one can expect very different benzene/benzene and water/water interactions. Benzene does not have a dipole moment, while water does. Analysis of the data in the crystal structures in the Cambridge Structural Database (CSD) revealed the most frequent benzene/benzene and water/water geometries. The majority of the benzene/benzene interactions in the crystal structures in the CSD are stacking interactions with large horizontal displacements, and not geometries that are minima on benzene/benzene potential surface. A large number of the water/water contacts in the CSD are hydrogen bonds, 70% of all attractive water/water interactions. In addition, water/water contacts with two water forming antiparallel interactions are 20% of all attractive water/water contacts. In these contacts, the O-H bonds of water molecules are in antiparallel orientation. In benzene/benzene interactions at large horizontal displacements, two C-H bonds also are in the antiparallel orientation. This shows that although the two molecules are different, both of them form antiparallel interactions with a local O-H and C-H dipole moments.
Multiparameter monitoring of cardiovascular function
Authors:   University of Belgrade, National Institute of Republic of Serbia, Vinča Institute of Nuclear Sciences, Serbia, Lazović Aleksandar , Đorđević Natalija ,   University of Belgrade, School of Electrical Engineering, Serbia, Tadić Predrag ,   University of Belgrade, School of Electrical Engineering, Serbia, Ivanović Marija ,   University of Belgrade, National Institute of Republic of Serbia, Vinča Institute of Nuclear Sciences, Serbia, Atanasoski Vladimir ,   University of Belgrade, National Institute of Republic of Serbia, Vinča Institute of Nuclear Sciences, Serbia, Miletić Marjan ,   University of Belgrade, National Institute of Republic of Serbia, Vinča Institute of Nuclear Sciences, Serbia, Hadžievski Ljupčo ,   University of Belgrade, National Institute of Republic of Serbia, Vinča Institute of Nuclear Sciences, Serbia, Ristić Arsen ,   University of Belgrade, Faculty of Medicine, University Clinical Center of Serbia, Department of Cardiology, Serbia, Vukčević Vladan ,   University of Belgrade, Faculty of Medicine, University Clinical Center of Serbia, Department of Cardiology, Serbia, Petrović Jovana ,   University of Belgrade, National Institute of Republic of Serbia, Vinča Institute of Nuclear Sciences, Serbia
Published: October 2023

We report the preliminary results of a laboratory validation study of a new polycardiographic device for the assessment of cardiovascular function (SensSmartTech). The main principle behind polycardiography is a synchronized measurement of multiple electro- mechanical parameters of the cardiovascular system. The assessment is non-invasive and entails electrocardiography, photoplethysmography, phonography and seismography. The study’s results validate the use of the proposed policardiograph implementation in settings with varying measurement and physiological conditions in both clinical and homecare settings. A simple signal analysis shows that the method is suitable for automated determination of diagnostically relevant features including the heart rhythm, openings and closures of heart valves, heart sounds, and systolic intervals generated as a combination of electrical and mechanical observables.
db.3d-qsar.com. The first 3D QSAR models database
Authors:   Sapienza Uniersity of Rome, Department of Drug chemistry and Technology, Italy, Ragno Rino , Ragno Alessio ,   Sapienza University, Department of Computer, Control, and Management Engineering, Italy
Published: October 2023

Field-Based Three-Dimensiona Quantitative Strucutere-Activity Relationships (FB 3D QSAR) comprise computational approaches used in drug design and molecular modeling to analyze the relationship between the three-dimensional structure of a list of molecules (described by molecular interaction fields) and their associated biological activities (BAs). It aims to understand how different structural features of the molecules contribute to enhancing or lowering the biological potency. The process of FB 3D QSAR involves several steps. First, a dataset of structurally diverse molecules with known BAs is selected. Then, their three-dimensional structures are generated using computational methods. Next, in the classical form of Cramer [1], sterical and electrostatic molecular interaction fields (MIFs) are calculated and as a final step a mathematical model is built through the correlation of BAs with MIFs by means of projection of latent structures (PLS) algorithm. With our interest in making 3D QSAR accessible to all as done with the www.3d-qsar.com [2] db.3d-qsar.com, the first publicly available database of 3D QSAR models, is presented in which the user can insert or draw a molecule and predict its potency against an available target. All the models available on db.3d-qsar.com have been heavily optimized in prediction power through a semi-systematic pretreatment and parameter selection procedure by initially dividing the datasets into training (80%) and prediction (20%) sets. Each published model was and will be prepared by a selection among thousands of alignment trials. The selected models were finally characterized using a validation set compiled with molecules taken from the ChEMBL database. At the time of writing more than 40 models associated to more than 30 different pharmacological targets have been prepared and are ready to be used. At the time of the presentation db.3d-qsar.com will be accessible to the public and during the presentation its features will be shown.
Application of Carbon-Based Nanocomposite Systems as Photosensitizers for Photodynamic Therapy
Authors:   University of Belgrade, National Institute of the Republic of Serbia, VINČA Institute of Nuclear Sciences, Serbia, Petković Marijana , Stepić Milutin ,   University of Belgrade, National Institute of the Republic of Serbia, VINČA Institute of Nuclear Sciences, Serbia, Popović Iva ,   University of Belgrade, National Institute of the Republic of Serbia, VINČA Institute of Nuclear Sciences, Serbia, Algarra Manuel ,   INAMAT2  -Public University of Navarre, Edificio Jeronimo de Ayanz, Spain, Dučić Tanja ,   ALBA CELLS Synchrotron, Spain, Abu el Rub Anamarija ,   University of Belgrade, National Institute of the Republic of Serbia, VINČA Institute of Nuclear Sciences, Serbia, Ralić Vanja ,   University of Belgrade, National Institute of the Republic of Serbia, VINČA Institute of Nuclear Sciences, Serbia, Korićanac Lela ,   University of Belgrade, National Institute of the Republic of Serbia, VINČA Institute of Nuclear Sciences, Serbia, Žakula Jelena ,   University of Belgrade, National Institute of the Republic of Serbia, VINČA Institute of Nuclear Sciences, Serbia, Filipović Tričković Jelena ,   University of Belgrade, National Institute of the Republic of Serbia, VINČA Institute of Nuclear Sciences, Serbia, Valenta Šobot Ana ,   University of Belgrade, National Institute of the Republic of Serbia, VINČA Institute of Nuclear Sciences, Serbia, Nešić Maja D. ,   University of Belgrade, National Institute of the Republic of Serbia, VINČA Institute of Nuclear Sciences, Serbia
Published: October 2023

Small, carbon-based nanoparticles, carbon dots (CDs), are investigated as photosensitizers (PSs) for photodynamic therapy of cancers. The results presented here show biochemical changes in cancer cells treated with surface-modified CDs, which are augmented by illumination, indicating a high potential of CDs as selective drug carriers and potent PSs. In addition, we will show that CDs produced from black carrot extract (biomass) can be exploited for image-guided therapy and be cytotoxic for cancer cells, thanks to their fluorescence properties. Finally, since biomass-fabricated CDs interact strongly with nucleic acids, they can be further developed for cell cycle sensing purposes.
Entropy dynamics for a propeller-shaped quantum Brownian molecular rotator
Authors:   University of Nis, Faculty of Science and Mathematics, Serbia, Jeknic-Dugic J. , Petrovic I. ,   University of Nis, Faculty of Science and Mathematics, Serbia, Kojic K. ,   University of Nis, Faculty of Science and Mathematics, Serbia, Arsenijevic M. ,   University of Kragujevac, Faculty of Science, Serbia, Dugic M. ,   University of Kragujevac, Faculty of Science, Serbia
Published: October 2023

We investigate and analyze the time dependence of the so-called differential entropy as a measure of the dynamical stability of a one-dimensional, propeller-shaped quantum Brownian molecular rotator. The larger the entropy change, the more profound the instability (lower control) of the rotator. The quantum molecular rotator is modelled by the quantum Caldeira-Leggett master equation while assuming the external harmonic field for the rotator. Rotational stability is found relatively high for the constructed Gaussian states, especially for molecules with a larger number of blades.
Biocorrosion, biofouling and health risk: biological activity reaction tests of selected brackish groundwater occurrences in Serbia
Authors:   University of Belgrade, Institute of Molecular Genetics and Genetic Engineering, Šaraba Vladimir , Nikodinović-Runić Jasmina ,   University of Belgrade, Institute of Molecular Genetics and Genetic Engineering,, Obradović Vesna ,   Jaroslav Černi Water Institute, Belgrade, Serbia, Dimkić Ivica ,   University of Belgrade, Faculty of Biology, Serbia, Janakiev Tamara ,   University of Belgrade, Faculty of Biology, Serbia, Dragišić Veselin ,   University of Belgrade, Faculty of Mining and Geology, Serbia, Ciric Milica ,   University of Belgrade, Institute of Molecular Genetics and Genetic Engineering,
Published: October 2023

Targeted physiological groups of bacteria were cultivated and identified in the brackish groundwaters of Obrenovačka Banja (OB), Lomnički Kiseljak (LK) and Velika Vrbnica (VV) using biological activity reaction tests (BARTs) to assess the biocorrosion, biofouling and health risks. The highest density of iron-related, sulfate-reducing, slime-forming, facultatively anaerobic heterotrophic, denitrifying bacteria and representatives of Pseudomonas spp. was recorded in the OB sample, while the lowest density of the same physiological groups of bacteria was recorded in the LK sample. Facultatively anaerobic heterotrophic bacteria were the most abundant in the OB and LK samples, while, in contrast, heterotrophic aerobic bacteria were the most abundant in the VV sample. All tested samples were characterized by a high degree of biochemical activity associated with iron-related, sulfate-reducing, slime-forming, heterotrophic aerobic and facultatively anaerobic bacteria. Also, high biochemical activity of denitrifying bacteria was recorded in the OB sample, and the same activity of Pseudomonas species was recorded in the OB and VV samples. For OB and LK groundwaters, the highest degree of risk was estimated for biocorrosion process, while for the OB and VV occurrences, the highest degree of risk was estimated for biofouling process. The health risk was present for all examined groundwaters. Caution is warranted in further use of all investigated occurrences due to the established public health risk and an immediate revitalization of the OB, LK and VV wells is necessary.
Analisis Yuridis Pelaksanaan Putusan Perkara Waris dengan Obyek Sengketa yang Telah Memiliki Sertifikat Hak Milik
Authors: Abdul Abdul
Published: October 2023

This research aims to analyze the legal aspects in the implementation of inheritance case decisions involving disputed properties that already have a property ownership certificate. The main focus of this research is to identify challenges and obstacles that may arise in the implementation of such decisions. The research method used is a normative analysis approach, which involves examining relevant laws and regulations, related jurisprudence, as well as relevant documents. The research findings indicate that the implementation of inheritance case decisions involving disputed properties with existing property ownership certificates involves a series of complex legal processes. The main challenge lies in harmonizing the court's decision with the validity of the previously issued property ownership certificate. Additionally, it is important to consider the rights of the parties involved that are protected by the law. This research also highlights the need for practical guidance or guidelines for parties involved in the implementation of such decisions, including judges, lawyers, and other relevant parties. These recommendations are expected to make a positive contribution to improving justice and effectiveness in resolving inheritance disputes involving properties with ownership certificates in the future.
A Clinical Audit of Presentation and Outcome of Salmonella Septicaemia
Authors: Habib AG
Published: October 2023

Introduction: Enteric fever is imported to developed countries while non-typhoidal salmonella infections occur globally. Clinicians and trainees need to recognise the varied presentations of serious salmonella infections.

Materials and Methods: We reviewed the clinical presentations, hospital course, complications and outcomes of 50 patients who were blood culture positive for Salmonella spp seen in 2 years.

Results: Nineteen of 24 patients with enteric fever had recently travelled to Asian countries. All the enteric fever patients recovered fully. Out of 26 patients with non-typhoidal salmonellosis, 10 had malignancies, 7 had immune dysfunction states and 3 had aortic aneurysms. Five patients had recurrent episodes of salmonellosis. Eight of these patients who had cancer (4), diabetes mellitus with renal failure (2) and gastric diseases (2) died. Fatal cases were older with multiple admissions and co-morbidities (median, 3) and presentation followed immunosuppressive interventions, often with no fever (4). Onset was sudden with a short and fatally unresponsive course despite effective antimicrobial agents with microbiologic diagnosis made posthumously (4). Death resulted rapidly from overwhelming sepsis and aneurysmal complications. Antibiotic resistance to ampicillin, cotrimoxazole and chloramphenicol was noted.

Conclusion: Enteric fever should be considered in travellers returning from Asian countries with fever, and third-generation cephalosporins or quinolones should be used for empiric treatment. Given the presentation of non-typhoidal salmonella septicaemias, clinicians need to have a high index of suspicion and to consider preemptive therapy in patients with prior infection who are likely to develop severe immunosuppression following interventions.
MELAS: A Case Report
Authors: Singh B , Low PS , Yeo JF
Published: October 2023

Introduction: Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) is a rare, neurodegenerative and fatal disease caused by mutations in the mitochondrial DNA. Multiple systems of the body, including the oral cavity, can be affected by this disease. An electronic search of Medline spanning the years 1985 to 2003 was carried out using the key words “MELAS, Dentistry.” It yielded no literature on the dental aspects of MELAS.

Clinical Picture: This report documents the case of a 6-year-old Chinese boy diagnosed with MELAS and highlights problems encountered in the multidisciplinary management of MELAS patients, including its dental management.

Treatment and Outcome: Dental management was successfully performed under general anaesthesia with close medical supervision by paediatrician and anaesthetist.

Conclusion: There is no known treatment of the underlying disease and the clinical course is usually unpredictable. Preventive dental care is important in this group of patients as concurrent medical conditions can complicate dental care.
A Case of a Diaphragmatic Rupture Complicated With Lacerations of Stomach and Spleen Caused by a Violent Cough Presenting With Mediastinal Shift
Authors: Kara E , Kaya Y , Zeybek R , Coskun T , Yavuz C
Published: October 2023

Introduction: Diapraghmatic rupture is a clinical case that is mostly seen following a blunt thoracoabdominal trauma or is rarely reported as spontaneously induced by various factors.

Clinical Picture: A 28-year-old man presented as an emergency with shortness of breath and severe abdominal pain following a violent cough. His chest radiography and computed tomography demonstrated left diaphragmatic rupture, mediastinal shift and herniation of gastric fundus into the pleural cavity.

Treatment: Left thoracotomy for the replacement of herniated gastric fundus and median laparotomy for the repair of serosal layer of gastric fundus and a diaphragmatic gap were performed.

Outcome: He made an uneventful recovery.

Conclusions: Diaphragmatic ruptures may be caused by violent coughing with serious life-threatening complications.
Reflections of a Septuagenarian – Radiology: Past, Present and Future
Authors: Chow KW
Published: October 2023

Before I commence, I would like to thank the Singapore Radiological Society and the Chapter of Radiologists of the Academy of Medicine for inviting me to speak today on the occasion of the inauguration of the FY Khoo Lectureship. I was initially hesitant.
The Effect of Work-life Balance on Employee Performance Through Job Satisfaction as an Intervening Variable
Authors: Agung Prasetyo Candra , Tri Wijayati Wardoyo Dewie
Published: October 2023

This study aims to measure and analyze the effect of work-life balance on employee performance through job satisfaction in commercial division employees of PT Aneka Jasa Grhadika. This research is a causal research that uses a quantitative approach, with a population consisting of 70 commercial division employees. Data analysis in this study used SEM-PLS with the help of SmartPLS3 software. This results of this study prove that work-life balance has a significant positive effect on employee performance, work-life balance has a positive and significant effect on job satisfaction, job satisfaction has a positive and significant effect on employee performance, and job satisfaction mediates between work-life balance employee performance.