bluuebunny/crossref_metadata_2025 huggingface dataset:
Degradation of Paracetamol by an UV/Chlorine Advanced Oxidation Process: Influencing Factors, Factorial Design, and Intermediates Identification
Authors: Dao Yen Hai , Tran Hai Nguyen , Tran-Lam Thien Thanh , Pham Trung Quoc , Le Giang Truong
Published: November 2018

The combination of a low-pressure mercury lamp and chlorine (UV/chlorine) was applied as an emerging advanced oxidation process (AOP), to examine paracetamol (PRC) degradation under different operational conditions. The results indicated that the UV/chlorine process exhibited a much faster PRC removal than the UV/H2O2 process or chlorination alone because of the great contribution of highly reactive species (•OH, •Cl, and ClO•). The PRC degradation rate constant (kobs) was accurately determined by pseudo-first-order kinetics. The kobs values were strongly affected by the operational conditions, such as chlorine dosage, solution pH, UV intensity, and coexisting natural organic matter. Response surface methodology was used for the optimization of four independent variables (NaOCl, UV, pH, and DOM). A mathematical model was established to predict and optimize the operational conditions for PRC removal in the UV/chlorine process. The main transformation products (twenty compound structures) were detected by liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS).
Geographical Variation in Oral and Oropharynx Cancer Mortality in Brazil: A Bayesian Approach
Authors: Prado da Fonseca Emílio , Cristina do Amaral Regiane , Carlos Pereira Antonio , Martins Rocha Carla , Tennant Marc
Published: November 2018

Recent studies have shown a high number of deaths from oral and oropharyngeal cancer worldwide, Brazil included. For this study, the deaths data (ICD-10, chapter II, categories C00 to C14) was obtained from Mortality Information System (SIM) and standardized by gender and population for each of the 554 Microregions of Brazil. The raw mortality rates were adopted as the standard and compared to the application of smoothing by the Bayesian model. In order to describe the geographical pattern of the occurrence of oral cancer, thematic maps were constructed, based on the distributions of mortality rates for Microregions and gender. Results: There were 7882 deaths registered due to oral and oropharyngeal cancer in Brazil, of which 6291 (79.81%) were male and 1591 (20.19%) female. The Empirical Bayesian Model presented greater scattering with mosaic appearance throughout the country, depicting high rates in Southeast and South regions interpolated with geographic voids of low rates in Midwest and North regions. For males, it was possible to identify expressive clusters in the Southeast and South regions. Conclusion: The Empirical Bayesian Model allowed an alternative interpretation of the oral and oropharynx cancer mortality mapping in Brazil.
Long Non-Coding RNAs as Mediators of Tumor Microenvironment and Liver Cancer Cell Communication
Authors: Lin Yang-Hsiang , Wu Meng-Han , Yeh Chau-Ting , Lin Kwang-Huei
Published: November 2018

The tumor microenvironment is an important concept that defines cancer development not only through tumor cells themselves but also the surrounding cellular and non-cellular components, including stromal cells, blood vessels, infiltrating inflammatory cells, cancer stem cells (CSC), cytokines, and growth factors, which act in concert to promote tumor cell survival and metastasis. Hepatocellular carcinoma (HCC) is one of the most common and aggressive human malignancies worldwide. Poor prognosis is largely attributable to the high rate of tumor metastasis, highlighting the importance of identifying patients at risk in advance and developing novel therapeutic targets to facilitate effective intervention. Long non-coding RNAs (lncRNA) are a class of non-protein coding transcripts longer than 200 nucleotides frequently dysregulated in various cancer types, which have multiple functions in widespread biological processes, including proliferation, apoptosis, metastasis, and metabolism. lncRNAs are involved in regulation of the tumor microenvironment and reciprocal signaling between cancer cells. Targeting of components of the tumor microenvironment or cancer cells has become a considerable focus of therapeutic research and establishing the effects of different lncRNAs on this network should aid in the development of effective treatment strategies. The current review provides a summary of the essential properties and functional roles of known lncRNAs associated with the tumor microenvironment in HCC.
RNA Sequencing-Based Bulked Segregant Analysis Facilitates Efficient D-genome Marker Development for a Specific Chromosomal Region of Synthetic Hexaploid Wheat
Authors: Nishijima Ryo , Yoshida Kentaro , Sakaguchi Kohei , Yoshimura Shin-ichi , Sato Kazuhiro , Takumi Shigeo
Published: November 2018

Common wheat originated from interspecific hybridization between cultivated tetraploid wheat and its wild diploid relative Aegilops tauschii followed by amphidiploidization. This evolutionary process can be reproduced artificially, resulting in synthetic hexaploid wheat lines. Here we performed RNA sequencing (RNA-seq)-based bulked segregant analysis (BSA) using a bi-parental mapping population of two synthetic hexaploid wheat lines that shared identical A and B genomes but included with D-genomes of distinct origins. This analysis permitted identification of D-genome-specific polymorphisms around the Net2 gene, a causative locus to hybrid necrosis. The resulting single nucleotide polymorphisms (SNPs) were classified into homoeologous polymorphisms and D-genome allelic variations, based on the RNA-seq results of a parental tetraploid and two Ae. tauschii accessions. The difference in allele frequency at the D-genome-specific SNP sites between the contrasting bulks (ΔSNP-index) was higher on the target chromosome than on the other chromosomes. Several SNPs with the highest ΔSNP-indices were converted into molecular markers and assigned to the Net2 chromosomal region. These results indicated that RNA-seq-based BSA can be applied efficiently to a synthetic hexaploid wheat population to permit molecular marker development in a specific chromosomal region of the D genome.
Trapping of an Heterometallic Unsaturated Hydride: Structure and Properties of the Ammonia Complex [MoMnCp(μ-H)(μ-PPh2)(CO)5(NH3)]
Authors: Alvarez M. Angeles , García-Vivó Daniel , Huergo Estefanía , Ruiz Miguel A.
Published: November 2018

Complexes displaying multiple bonds between different metal atoms have considerable synthetic potential because of the combination of the high electronic and coordinative unsaturation associated to multiple bonds with the intrinsic polarity of heterometallic bonds but their number is scarce and its chemistry has been relatively little explored. In a preliminary study, our attempted synthesis of the unsaturated hydrides [MoMCp(μ-H)(μ-PR2)(CO)5] from anions [MoMCp(μ-PR2)(CO)5]− and (NH4)PF6 yielded instead the ammonia complexes [MoMCp(μ-H)(μ-PR2)(CO)5(NH3)] (M = Mn, R = Ph; M = Re, R = Cy). We have now examined the structure and behaviour of the MoMn complex (Mo–Mn = 3.087(3) Å) and found that it easily dissociates NH3 (this requiring some 40 kJ/mol, according to DFT calculations), to yield the undetectable unsaturated hydride [MoMnCp(μ-H)(μ-PPh2)(CO)5] (computed Mo–Mn = 2.796 Å), the latter readily adding simple donors L such as CNR (R = Xyl, p-C6H4OMe) and P(OMe)3, to give the corresponding electron-precise derivatives [MoMnCp(μ-H)(μ-PPh2)(CO)5(L)]. Thus the ammonia complex eventually behaves as a synthetic equivalent of the unsaturated hydride [MoMnCp(μ-H)(μ-PPh2)(CO)5]. The isocyanide derivatives retained the stereochemistry of the parent complex (Mo–Mn = 3.0770(4) Å when R = Xyl) but a carbonyl rearrangement takes place in the reaction with phosphite to leave the entering ligand trans to the PPh2 group, a position more favoured on steric grounds.
A Study on Drilling High-Strength CFRP Laminates: Frictional Heat and Cutting Temperature
Authors: Xu Jinyang , Li Chao , Dang Jiaqiang , El Mansori Mohamed , Ren Fei
Published: November 2018

High-strength carbon fiber reinforced polymer (CFRP) composites have become popular materials to be utilized in the aerospace and automotive industries, due to their unique and superior mechanical properties. An understanding of cutting temperatures is rather important when dealing with high-strength CFRPs, since machining defects are likely to occur because of high temperatures (especially in the semi-closed drilling process). The friction behavior at the flank tool-workpiece interface when drilling CFRPs plays a vital role in the heat generation, which still remains poorly understood. The aim of this paper is to address the friction-induced heat based on two specially-designed tribometers to simulate different sliding velocities, similar to those occurring along the flank tool-work interface in drilling. The elastic recovery effect during the drilling process was considered during the tribo-drilling experiments. The drilling temperatures were calculated by the analytical model and verified by the in-situ experimental results gained using the embedded thermocouples into the drills. The results indicate that the magnitudes of the interfacial friction coefficients between the cemented carbide tool and the CFRP specimen are within the range between 0.135–0.168 under the examined conditions. Additionally, the friction caused by the plastic deformation and elastic recovery effects plays a dominant role when the sliding velocity increases. The findings in this paper point out the impact of the friction-induced heat and cutting parameters on the overall drilling temperature.
Exploring the Difference in Bainite Transformation with Varying the Prior Austenite Grain Size in Low Carbon Steel
Authors: Lan Liangyun , Chang Zhiyuan , Fan Penghui
Published: November 2018

The simulation welding thermal cycle technique was employed to generate different sizes of prior austenite grains. Dilatometry tests, in situ laser scanning confocal microscopy, and transmission electron microscopy were used to investigate the role of prior austenite grain size on bainite transformation in low carbon steel. The bainite start transformation (Bs) temperature was reduced by fine austenite grains (lowered by about 30 °C under the experimental conditions). Through careful microstructural observation, it can be found that, besides the Hall–Petch strengthening effect, the carbon segregation at the fine austenite grain boundaries is probably another factor that decreases the Bs temperature as a result of the increase in interfacial energy of nucleation. At the early stage of the transformation, the bainite laths nucleate near to the grain boundaries and grow in a “side-by-side” mode in fine austenite grains, whereas in coarse austenite grains, the sympathetic nucleation at the broad side of the pre-existing laths causes the distribution of bainitic ferrite packets to be interlocked.
Formation of Interfacial Reaction Layers in Al2O3/SS 430 Brazed Joints Using Cu-7Al-3.5Zr Alloys
Authors: Heo Hoejun , Joung Hyeonim , Jung Keeyoung , Kang Chung-Yun
Published: November 2018

The formation of interfacial reaction layers was investigated in an α-Al2O3/430 stainless steel (SS430) joint brazed using a Cu-7Al-3.5Zr active brazing alloy. Brazing was conducted at above its eutectic temperature of 945 °C and below liquidus 1045 °C, where liquid and solid phases of the brazing alloys coexists. At 1000 °C, the liquid phase of the brazing alloy was wet onto the α-Al2O3 surface. Zr in the liquid phase reduced α-Al2O3 to form a continuous ZrO2 layer. As the dwell time increased, Zr in the liquid phases near α-Al2O3 interface was used up to thicken the reaction layers. The growth kinetics of the layer obeys the parabolic rate law with a rate constant of 9.25 × 10−6 cm·s−1/2. It was observed that a number of low yield strength Cu-rich particles were dispersed over the reaction layer, which can release the residual stress of the joint resulting in reduction of crack occurrence.
Microfabrication of Micropore Array for Cell Separation and Cell Assay
Authors: Liu Yaoping , Xu Han , Zhang Lingqian , Wang Wei
Published: November 2018

Micropore arrays have attracted a substantial amount of attention due to their strong capability to separate specific cell types, such as rare tumor cells, from a heterogeneous sample and to perform cell assays on a single cell level. Micropore array filtration has been widely used in rare cell type separation because of its potential for a high sample throughput, which is a key parameter for practical clinical applications. However, most of the present micropore arrays suffer from a low throughput, resulting from a low porosity. Therefore, a robust microfabrication process for high-porosity micropore arrays is urgently demanded. This study investigated four microfabrication processes for micropore array preparation in parallel. The results revealed that the Parylene-C molding technique with a silicon micropillar array as the template is the optimized strategy for the robust preparation of a large-area and high-porosity micropore array, along with a high size controllability. The Parylene-C molding technique is compatible with the traditional micromechanical system (MEMS) process and ready for scale-up manufacture. The prepared Parylene-C micropore array is promising for various applications, such as rare tumor cell separation and cell assays in liquid biopsy for cancer precision medicine.
Screening of a Library of Oligosaccharides Targeting Lectin LecB of Pseudomonas Aeruginosa and Synthesis of High Affinity Oligoglycoclusters
Authors: Dupin Lucie , Noël Mathieu , Bonnet Silvère , Meyer Albert , Géhin Thomas , Bastide Ludovic , Randriantsoa Mialy , Souteyrand Eliane , Cottin Claire , Vergoten Gérard , Vasseur Jean-Jacques , Morvan François , Chevolot Yann , Darblade Benoît
Published: November 2018

The Gram negative bacterium Pseudomonas aeruginosa (PA) is an opportunistic bacterium that causes severe and chronic infection of immune-depressed patients. It has the ability to form a biofilm that gives a selective advantage to the bacteria with respect to antibiotherapy and host defenses. Herein, we have focused on the tetrameric soluble lectin which is involved in bacterium adherence to host cells, biofilm formation, and cytotoxicity. It binds to l-fucose, d-mannose and glycan exposing terminal fucose or mannose. Using a competitive assay on microarray, 156 oligosaccharides and polysaccharides issued from fermentation or from the biomass were screened toward their affinity to LecB. Next, the five best ligands (Lewisa, Lewisb, Lewisx, siayl-Lewisx and 3-fucosyllactose) were derivatized with a propargyl aglycon allowing the synthesis of 25 trivalent, 25 tetravalent and 5 monovalent constructions thanks to copper catalyzed azide alkyne cycloaddition. The 55 clusters were immobilized by DNA Directed immobilization leading to the fabrication of a glycocluster microarray. Their binding to LecB was studied. Multivalency improved the binding to LecB. The binding structure relationship of the clusters is mainly influenced by the carbohydrate residues. Molecular simulations indicated that the simultaneous contact of both binding sites of monomer A and D seems to be energetically possible.
Skin Permeation of Solutes from Metalworking Fluids to Build Prediction Models and Test A Partition Theory
Authors: Hughes-Oliver Jacqueline M. , Xu Guangning , Baynes Ronald E.
Published: November 2018

Permeation of chemical solutes through skin can create major health issues. Using the membrane-coated fiber (MCF) as a solid phase membrane extraction (SPME) approach to simulate skin permeation, we obtained partition coefficients for 37 solutes under 90 treatment combinations that could broadly represent formulations that could be associated with occupational skin exposure. These formulations were designed to mimic fluids in the metalworking process, and they are defined in this manuscript using: one of mineral oil, polyethylene glycol-200, soluble oil, synthetic oil, or semi-synthetic oil; at a concentration of 0.05 or 0.5 or 5 percent; with solute concentration of 0.01, 0.05, 0.1, 0.5, 1, or 5 ppm. A single linear free-energy relationship (LFER) model was shown to be inadequate, but extensions that account for experimental conditions provide important improvements in estimating solute partitioning from selected formulations into the MCF. The benefit of the Expanded Nested-Solute-Concentration LFER model over the Expanded Crossed-Factors LFER model is only revealed through a careful leave-one-solute-out cross-validation that properly addresses the existence of replicates to avoid an overly optimistic view of predictive power. Finally, the partition theory that accompanies the MCF approach is thoroughly tested and found to not be supported under complex experimental settings that mimic occupational exposure in the metalworking industry.
Nitrogen-Fixing Bacteria Associated with Peltigera Cyanolichens and Cladonia Chlorolichens
Authors: Almendras Katerin , García Jaime , Carú Margarita , Orlando Julieta
Published: November 2018

Lichens have been extensively studied and described; however, recent evidence suggests that members of the bacterial community associated with them could contribute new functions to the symbiotic interaction. In this work, we compare the nitrogen-fixing guild associated with bipartite terricolous lichens with different types of photobiont: Peltigera cyanolichens and Cladonia chlorolichens. Since cyanobacteria contribute nitrogen to the symbiosis, we propose that chlorolichens have more diverse bacteria with the ability to fix nitrogen compared to cyanolichens. In addition, since part of these bacteria could be recruited from the substrate where lichens grow, we propose that thalli and substrates share some bacteria in common. The structure of the nitrogen-fixing guild in the lichen and substrate bacterial communities of both lichens was determined by terminal restriction fragment length polymorphism (TRFLP) of the nifH gene. Multivariate analyses showed that the nitrogen-fixing bacteria associated with both types of lichen were distinguishable from those present in their substrates. Likewise, the structure of the nitrogen-fixing bacteria present in the cyanolichens was different from that of chlorolichens. Finally, the diversity of this bacterial guild calculated using the Shannon index confirms the hypothesis that chlorolichens have a higher diversity of nitrogen-fixing bacteria than cyanolichens.
TfOH-Promoted Reaction of 2,4-Diaryl-1,1,1-Trifluorobut-3-yn-2-oles with Arenes: Synthesis of 1,3-Diaryl-1-CF3-Indenes and Versatility of the Reaction Mechanisms
Authors: Zerov Aleksey V. , Kazakova Anna N. , Boyarskaya Irina A. , Panikorovskii Taras L. , Suslonov Vitalii V. , Khoroshilova Olesya V. , Vasilyev Aleksander V.
Published: November 2018

The TfOH-mediated reactions of 2,4-diaryl-1,1,1-trifluorobut-3-yn-2-oles (CF3-substituted diaryl propargyl alcohols) with arenes in CH2Cl2 afford 1,3-diaryl-1-CF3-indenes in yields up to 84%. This new process for synthesis of such CF3-indenes is complete at room temperature within one hour. The synthetic potential, scope, and limitations of this reaction were illustrated by more than 70 examples. The proposed reaction mechanism invokes the formation of highly reactive CF3-propargyl cation intermediates that can be trapped at the two mesomeric positions by the intermolecular nucleophilic attack of an arene partner with a subsequent intramolecular ring closure.
Association between 25-Hydroxyvitamin D Status and Components of Body Composition and Glucose Metabolism in Older Men and Women
Authors: Mathieu Svea-Vivica , Fischer Karina , Dawson-Hughes Bess , Freystaetter Gregor , Beuschlein Felix , Schietzel Simeon , Egli Andreas , Bischoff-Ferrari Heike A.
Published: November 2018

Obesity and sarcopenia are major causes of morbidity and mortality among seniors. Vitamin D deficiency is very common especially among seniors and has been associated with both muscle health and obesity. This study investigated if 25-hydroxyvitamin D (25(OH)D) status is associated with body composition and insulin resistance using baseline data of a completed RCT among relatively healthy community-dwelling seniors (271 seniors age 60+ years undergoing elective surgery for unilateral total knee replacement due to osteoarthritis). Cross-sectional analysis compared appendicular lean mass index (ALMI: lean mass kg/height m2) and fat mass index (FMI: fat mass kg/height m2) assessed by DXA and insulin resistance between quartiles of serum 25(OH)D concentration using multivariable linear regression adjusted for age, sex, smoking status, physical activity, and body mass index (BMI). Participants in the lowest serum 25(OH)D quartile (4.7–17.5 ng/mL) had a higher fat mass (9.3 kg/m2) compared with participants in the third (8.40 kg/m2; Q3 = 26.1–34.8 ng/mL) and highest (8.37 kg/m2; Q4 = 34.9–62.5 ng/mL) quartile (poverall = 0.03). Higher serum 25(OH)D quartile status was associated with higher insulin sensitivity (poverall = 0.03) and better beta cell function (p = 0.004). Prevalence of insulin resistance tended to be higher in the second compared with the highest serum 25(OH)D quartile (14.6% vs. 4.8%, p = 0.06). Our findings suggest that lower serum 25(OH)D status may be associated with greater fat mass and impaired glucose metabolism, independent of BMI and other risk factors for diabetes.
Complementary Biomarker Assessment of Components Absorbed from Diet and Creatinine Excretion Rate Reflecting Muscle Mass in Dialysis Patients
Authors: Post Adrian , Ozyilmaz Akin , Westerhuis Ralf , Ipema Karin J. R. , Bakker Stephan J. L. , Franssen Casper F. M.
Published: November 2018

To prevent protein energy malnutrition (PEM) and accumulation of waste products, dialysis patients require diet adjustments. Dietary intake assessed by self-reported intakes often provides biased information and standard 24-h urinary excretion is inapplicable in dialysis patients. We aimed to assess dietary intake via a complementary, less biased biomarker method, and to compare this to dietary diaries. Additionally, we investigated the prospective association of creatinine excretion rate (CER) reflecting muscle mass with mortality. Complete intradialytic dialysate and interdialytic urinary collections were used to calculate 24-h excretion of protein, sodium, potassium, phosphate and creatinine in 42 chronic dialysis patients and compared with protein, sodium, potassium, and phosphate intake assessed by 5-day dietary diaries. Cox regression analyses were employed to investigate associations of CER with mortality. Mean age was 64 ± 13 years and 52% were male. Complementary biomarker assessed (CBA) and dietary assessed (DA) protein intake were significantly correlated (r = 0.610; p < 0.001), but there was a constant bias, as dietary diaries overestimated protein intake in most patients. Correlations were found between CBA and DA sodium intake (r = 0.297; p = 0.056), potassium intake (r = 0.312; p = 0.047) and phosphate uptake/intake (r = 0.409; p = 0.008). However, Bland-Altman analysis showed significant proportional bias. During a median follow-up of 26.6 (25.3–31.5) months, nine dialysis patients (23%) died. CER was independently and inversely associated with survival (HR: 0.59 (0.42–0.84); p = 0.003). Excretion measurements may be a more reliable assessment of dietary intake in dialysis patients, as this method is relatively free from biases known to exist for self-reported intakes. CER seems to be a promising tool for monitoring PEM.
Plasticizers Derived from Biomass Resources: A Short Review
Authors: Jia Puyou , Xia Haoyu , Tang Kehan , Zhou Yonghong
Published: November 2018

With rising environmental concerns and depletion of petrochemical resources, biomass-based chemicals have been paid more attention. Polyvinyl chloride (PVC) plasticizers derived from biomass resources (vegetable oil, cardanol, vegetable fatty acid, glycerol and citric acid) have been widely studied to replace petroleum-based o-phthalate plasticizers. These bio-based plasticizers mainly include epoxidized plasticizer, polyester plasticizer, macromolecular plasticizer, flame retardant plasticizer, citric acid ester plasticizer, glyceryl ester plasticizer and internal plasticizer. Bio-based plasticizers with the advantages of renewability, degradability, hypotoxicity, excellent solvent resistant extraction and plasticizing performances make them potential to replace o-phthalate plasticizers partially or totally. In this review, we classify different types of bio-based plasticizers according to their chemical structure and function, and highlight recent advances in multifunctional applications of bio-based plasticizers in PVC products. This study will increase the interest of researchers in bio-based plasticizers and the development of new ideas in this field.
Model Driven Development Applied to Complex Event Processing for Near Real-Time Open Data
Authors: Clemente Pedro J. , Lozano-Tello Adolfo
Published: November 2018

Nowadays, data are being produced like never before because the use of the Internet of Things, social networks, and communication in general are increasing exponentially. Many of these data, especially those from public administrations, are freely offered using the open data concept where data are published to improve their reutilisation and transparency. Initially, the data involved information that is not updated continuously such as budgets, tourist information, office information, pharmacy information, etc. This kind of information does not change during large periods of time, such as days, weeks or months. However, when open data are produced near to real-time such as air quality sensors or people counters, suitable methodologies and tools are lacking to identify, consume, and analyse them. This work presents a methodology to tackle the analysis of open data sources using Model-Driven Development (MDD) and Complex Event Processing (CEP), which help users to raise the abstraction level utilised to manage and analyse open data sources. That means that users can manage heterogeneous and complex technology by using domain concepts defined by a model that could be used to generate specific code. Thus, this methodology is supported by a domain-specific language (DSL) called OpenData2CEP, which includes a metamodel, a graphical concrete syntax, and a model-to-text transformation to specific platforms, such as complex event processing engines. Finally, the methodology and the DSL have been applied to two near real-time contexts: the analysis of air quality for citizens’ proposals and the analysis of earthquake data.
Optical Biosensors for Label-Free Detection of Small Molecules
Authors: Peltomaa Riikka , Glahn-Martínez Bettina , Benito-Peña Elena , Moreno-Bondi María C.
Published: November 2018

Label-free optical biosensors are an intriguing option for the analyses of many analytes, as they offer several advantages such as high sensitivity, direct and real-time measurement in addition to multiplexing capabilities. However, development of label-free optical biosensors for small molecules can be challenging as most of them are not naturally chromogenic or fluorescent, and in some cases, the sensor response is related to the size of the analyte. To overcome some of the limitations associated with the analysis of biologically, pharmacologically, or environmentally relevant compounds of low molecular weight, recent advances in the field have improved the detection of these analytes using outstanding methodology, instrumentation, recognition elements, or immobilization strategies. In this review, we aim to introduce some of the latest developments in the field of label-free optical biosensors with the focus on applications with novel innovations to overcome the challenges related to small molecule detection. Optical label-free methods with different transduction schemes, including evanescent wave and optical fiber sensors, surface plasmon resonance, surface-enhanced Raman spectroscopy, and interferometry, using various biorecognition elements, such as antibodies, aptamers, enzymes, and bioinspired molecularly imprinted polymers, are reviewed.
Situational Awareness: Mapping Interference Sources in Real-Time Using a Smartphone App
Authors: Nguyen Hong Lam , Troglia Gamba Micaela , Falletti Emanuela , Ta Tung Hai
Published: November 2018

In the past years, many techniques have been researched and developed to detect and identify the interference sources of Global Navigation Satellite System (GNSS) signals. In this paper, we utilize a simple and portable application to map interference sources in real-time. The results are promising and show the potential of the crowdsourcing for monitoring and mapping GNSS interference distribution.
Sustainable Logistics Management in the 21st Century Requires Wholeness Systems Thinking
Authors: Holman David , Wicher Pavel , Lenort Radim , Dolejšová Venuše , Staš David , Giurgiu Ioana
Published: November 2018

The 21st century is characterised by the unprecedented speed and scope of changes, creating a new external environment, where the logistics systems are managed. The latest development in logistics management is influenced by sustainability, which complements the economic dimension with environmental and social dimensions. The fundamental principle of logistics management is systems thinking (ST). Until now, the reductionism ST (RST), focusing on the maximal economic performance of a logistics system’s parts and interactions has been applied. However, the RST approach does not sufficiently consider the implication of the external environment to the economic performance. The article’s aim is the introduction of the new wholeness ST (WST) approach and confirmation of its fundamental role in deriving of the performance of the selected logistics system’s parts and interactions from the external environment. WST’s role was demonstrated in a case study, comparing the WST and RST approach in management of particular automotive logistics’ system. The WST approach in the management of the whole selected logistics system assures a considerable reduction in the consumption of resources. Based on the comparative case study’s results, the conceptual framework for the application of the WST approach in all sustainable dimensions is proposed.
Toward a Circular Economy Regional Monitoring Framework for European Regions: Conceptual Approach
Authors: Avdiushchenko Anna
Published: November 2018

This paper presents the development of a concept for a circular economy (CE) regional monitoring framework for European countries, an example that can be used by regional policymakers as a supportive instrument for faster and more effective implementation of the CE model of regional development. The work identifies appropriate focus areas and ‘pillars’ for such a framework, and proposes key aspects for evaluating CE-based regional development. The concept for the CE regional monitoring framework is divided into a basic (conceptual) level and an applied (practical) level in order to connect the concept of CE with its practical implementation, evaluation, and monitoring in a given region. The study also highlights the European context of the CE concept and its similarities and differences in relation to existing CE concepts around the world.
Competitive Analyses of the Pig Industry in Swaziland
Authors: Ndwandwe Sandile Birthwell , Weng Ruey-Chee
Published: November 2018

Over recent decades, Swaziland’s pork industry has been stagnant, failing to meet the domestic demand for pork. It is only in recent years that the number of pig farmers has increased rapidly, with smallholder farmers taking the lead. However, while higher demand for pork could lead to opportunities for growth, with uncertain future markets, increased pig production capacity could subject farmers to extreme market competition and failure to sell their produce. This study used a survey and SWOT analysis to assess the current pig production and market performance of smallholder farms in Swaziland. To quantify SWOT factors, the Analytical Hierarchy Process (AHP) was used to derive priorities for subsequent formulation of potential pig production strategies that are resilient both to market and climate changes. Strategy formulation was based on Porter’s cost leadership strategy. The findings revealed that, currently, the pig industry is attractive, and that the present is probably the best time for smallholder farmers to maximize their profits. Unfortunately, the industry was found to be threatened by the expected increase in production capacity, future market competition, and the socio-environmental challenges associated with expansion. Despite this, the findings suggest that smallholder farmers can survive future market challenges by strategically using agro-industrial by-products as alternative feed ingredients to reduce production cost. The formation of farmers’ associations could benefit smallholder farmers through economies of scale, processing and product value addition, and increased access to markets, and unity could strengthen their position in the market when bargaining for better prices.
From Collaborative to Hegemonic Water Resource Governance through Dualism and Jeong: Lessons Learned from the Daegu-Gumi Water Intake Source Conflict in Korea
Authors: Cho Ki Woong , Jung Kyujin
Published: November 2018

Recently, water supplies have been insufficient in some areas. In South Korea, using dualism and Jeongish citizenship, we will demonstrate why collaborative governance of the Daegu–Gumi Water Commission has not worked and how it has been mismanaged by its stakeholders. We discuss the conflict between the Daegu Metropolitan City (hereafter referred to as City of Daegu) and the City of Gumi regarding the relocation of the water intake source. In response to many water pollution accidents, the City of Daegu decided to move the water intake source to near the City of Gumi. Due to a conflict between the cities on this issue, the city established a collaborative governance entity, the Daegu–Gumi Water Commission. However, this form of governance was not successful, and eventually, the Daegu–Gumi Water Commission moved from collaborative governance to hegemonic governance. This was due to dualism and Jeongish citizenship with weak membership, participation, experience, and social capital on the local level as South Korean civil societies tend to have insufficient power and experience to fulfill their intentions or negotiate successfully. The Daegu–Gumi Water Commission failed to reach a consensus and to realize a truly collaborative governance process.
Single-Phase Active Power Harmonics Filter by Op-Amp Circuits and Power Electronics Devices
Authors: Samadaei Emad , Iranian Mina , Rezanejad Mohammad , Godina Radu , Pouresmaeil Edris
Published: November 2018

This paper introduces a new structure for single-phase Active Power Harmonics Filter (APHF) with the simple and low-cost controller to eliminate harmonics and its side effects on low voltage grid. The proposed APHF includes an accurate harmonic detector circuit, amplifier circuit to trap tiny harmonics, switching driver circuit for precise synchronization, and inverter to create injection current waveform, which is extracted from reference signal. The control circuits are based on electrostatic devices consist of Op-Amp circuits. Fast dynamic, simplicity, low cost, and small size are the main features of Op-Amp circuits that are used in the proposed topology. The aim is removing the all grid harmonic orders in which the proposed APF injects an appropriate current into the grid in parallel way. The proposed control system is smart enough to compensate all range of current harmonics. A prototype is implemented in the power electronics laboratory and it is installed as parallel on a distorted grid by the non-linear load (15 APeak-Peak) to verify the compensating of harmonics. The harmonics are compensated from THD% = 24.48 to THD% = 2.86 and the non-sinusoidal waveform is renovated to sinusoidal waveform by the proposed APHF. The experimental results show a good accurate and high-quality performance.
Marine Oil Spill Detection Based on the Comprehensive Use of Polarimetric SAR Data
Authors: Li Yu , Zhang Yuanzhi , Yuan Zifeng , Guo Huaqiu , Pan Hongyuan , Guo Jingjing
Published: November 2018

As a major marine pollution source, oil spills largely threaten the sustainability of the coastal environment. Polarimetric synthetic aperture radar remote sensing has become a promising approach for marine oil spill detection since it could effectively separate crude oil and biogenic look-alikes. However, on the sea surface, the signal to noise ratio of Synthetic Aperture Radar (SAR) backscatter is usually low, especially for cross-polarized channels. In practice, it is necessary to combine the refined detail of slick-sea boundary derived from the co-polarized channel and the highly accurate crude slick/look-alike classification result obtained based on the polarimetric information. In this paper, the architecture for oil spill detection based on polarimetric SAR is proposed and analyzed. The performance of different polarimetric SAR filters for oil spill classification are compared. Polarimetric SAR features are extracted and taken as the input of Staked Auto Encoder (SAE) to achieve high accurate classification between crude oil, biogenic slicks, and clean sea surface. A post-processing method is proposed to combine the classification result derived from SAE and the refined boundary derived from VV channel power image based on special density thresholding (SDT). Experiments were conducted on spaceborne fully polarimetric SAR images where both crude oil and biogenic slicks were presented on the sea surface.
Toward a Computer Vision Perspective on the Visual Impact of Vegetation in Symmetries of Urban Environments
Authors: Samiei Salma , Rasti Pejman , Daniel Hervé , Belin Etienne , Richard Paul , Rousseau David
Published: November 2018

Rapid urbanization is a worldwide critical environmental challenge. With this urban migration soaring, we need to live far more efficiently than we currently do by incorporating the natural world in new and innovative ways. There are a lot of researches on ecological, architectural or aesthetic points of view to address this issue. We present a novel approach to assess the visual impact of vegetation in urban street pedestrian view with the assistance of computer vision metrics. We statistically evaluate the correlations of the amount of vegetation with objective computer vision traits such as Fourier domain, color histogram, and estimated depth from monocular view. We show that increasing vegetation in urban street views breaks the orthogonal symmetries of urban blocks, enriches the color space with fractal-like symmetries and decreases the cues of projective geometry in depth. These uncovered statistical facts are applied to predict the requested amount of vegetation to make urban street views appear like natural images. Interestingly, these amounts are found in accordance with the ecosystemic approach for urban planning. Also, the study opens new questions for the understanding of the link between geometry and depth perception.
Fungal Endophytes Control Fusarium graminearum and Reduce Trichothecenes and Zearalenone in Maize
Authors: F. Abdallah Mohamed , De Boevre Marthe , Landschoot Sofie , De Saeger Sarah , Haesaert Geert , Audenaert Kris
Published: November 2018

Fusarium graminearum can cause Giberella Ear Rot (GER) and seedling blight in maize, resulting in major yield losses. Besides GER, the infected grains are consequently contaminated with multiple mycotoxins of F. graminearum. Zearalenone and trichothecenes, such as deoxynivalenol and its acetylated forms, are among the major mycotoxins associated with F. graminearum infection in maize. In the current work, we explored the effect of the endophytic fungal genera of Epicoccum and Sordaria, to control F. graminearum infection in comparative trials with Piriformospora spp., an elusive endophytic genus. Furthermore, we investigated the effect of these endophytes on zearalenone, deoxynivalenol, and 15-acetyldeoxynivalenol levels using in vitro and in planta assays. As plants are endowed with several detoxification mechanisms comprising e.g., glucosylation of trichothecenes, the effect of the isolated fungal endophytes on the deoxynivalenol-3-glucoside level was also assessed. In general, results showed a considerable variability in the antifungal activity, both among species and among isolates within one species. Additionally, the effect on mycotoxin levels was variable, and not necessarily related to the antifungal activity except for zearalenone levels which were consistently reduced by the endophytes. These results highlight the great potential of certain endophytic fungal strains as new biocontrol agents in agricultural science.
Analysis of the Fungal Community in Ziziphi Spinosae Semen through High-Throughput Sequencing
Authors: Guo Mengyue , Jiang Wenjun , Luo Jiaoyang , Yang Meihua , Pang Xiaohui
Published: November 2018

Ziziphi Spinosae Semen (ZSS) has been widely used in traditional Chinese medicine system for decades. Under proper humidity and temperature, ZSS is easily contaminated by fungi and mycotoxins during harvest, storage, and transport, thereby posing a considerable threat to consumer health. In this study, we first used the Illumina MiSeq PE250 platform and targeted the internal transcribed spacer 2 sequences to investigate the presence of fungi in moldy and normal ZSS samples collected from five producing areas in China. Results showed that all 14 samples tested were contaminated by fungi. Ascomycota was the dominant fungus at the phylum level, accounting for 64.36–99.74% of the fungal reads. At the genus level, Aspergillus, Candida, and Wallemia were the most predominant genera, with the relative abundances of 13.52–87.87%, 0.42–64.56%, and 0.06–34.31%, respectively. Meanwhile, 70 fungal taxa were identified at the species level. Among these taxa, three potential mycotoxin-producing fungi, namely, Aspergillus flavus, A. fumigatus, and Penicillium citrinum that account for 0.30–36.29%, 0.04–7.37%, and 0.01–0.80% of the fungal reads, respectively, were detected in all ZSS samples. Moreover, significant differences in fungal communities were observed in the moldy and normal ZSS samples. In conclusion, our results indicated that amplicon sequencing is feasible for the detection and analysis of the fungal community in the ZSS samples. This study used a new approach to survey the fungal contamination in herbal materials. This new approach can provide early warning for mycotoxin contamination in herbal materials, thereby ensuring drug efficacy and safety.
Leveraging Hydrologic Accounting and Water Markets for Improved Water Management: The Case for a Central Clearinghouse
Authors: Maples Stephen R. , Bruno Ellen M. , Kraus-Polk Alejo W. , Roberts Stacy N. , Foster Lauren M.
Published: November 2018

Effective management of water resources requires signaling the scarcity value of water to society. However, accurate signaling is often limited by incomplete and/or untimely accounting of hydrologic stores and flows of water. In this opinion piece, we advocate an incisive yet conceptually simple framework for transparent, real-time accounting of water stores and flows, including both groundwater and surface water, to inform water markets organized around a central clearinghouse. This framework promotes forthright collaboration among disciplines to improve system efficiency and increase water-management transparency. We use California water management as an example for the potential for a central clearinghouse framework that has proven so beneficial to transparency of energy markets in that region.
Collaborative, Risk-Informed, Triple Bottom Line, Multi-Criteria Decision Analysis Planning Framework for Integrated Urban Water Management
Authors: Cole Jeanne , Sharvelle Sybil , Grigg Neil , Pivo Gary , Haukaas Jon
Published: November 2018

The historical division of water management into different sectors, with financially and technologically driven decision processes, makes taking a more holistic approach to finding sustainable solutions for urban water management difficult. Here, a planning framework for Integrated Urban Water Management (IUWM) that evolved during a two-year study evaluating alternative strategies for dual water supply within a local government context is described. The planning framework was developed to overcome the obstacles that surfaced over the course of the study. It provides a structured approach to strategic decision making that integrates triple bottom line (TBL), multi-criteria decision analysis (MCDA), uncertainty and sensitivity analyses, and participatory decision making into an exploration of water supply alternatives. TBL assured stakeholders that the decisions considered the financial, social, and environmental performance. MCDA provided visibility into the benefits and trade-offs of the alternatives by providing a quantitative method for comparing alternatives that incorporates incommensurate performance indicators and priorities of multiple stakeholders. Uncertainty and sensitivity analyses addressed concerns regarding decision risk and improved transparency into inputs driving uncertainty in the analysis. Finally, a flexible participatory process helped to circumvent socio-institutional barriers by adapting the methodology and increasing cooperation among stakeholders and multidisciplinary experts. The resulting collaborative, risk-informed, TBL-MCDA (CRTM) planning framework helps to refine the feasible set of alternatives by providing more transparency into the drivers, technologies, and stakeholders influencing the decision. The planning framework increased the number of participants that were involved in the study, increased interaction between participants, changed the structure of the decision problem, increased the number of performance indicators considered, and improved stakeholder cooperation in the decision process.
Groundwater Development for Dry Season Irrigation in North East Ghana: The Place of Local Knowledge
Authors: Kwoyiga Lydia , Stefan Catalin
Published: November 2018

The use of groundwater resources for dry season irrigation has gained currency in Ghana. The north-east of the country has seen the cultivation of vegetables using groundwater from shallow aquifers; an emerging livelihood activity which lessens food insecurity and stems the tide of rural–urban migration. This practice in northern Ghana is deeply rooted in local knowledge. Using the Atankwidi catchment, this paper examines the role of local knowledge in understanding and exploiting groundwater for irrigation. A qualitative approach was used which allowed for in-depth catchment-level investigations, using group discussions, key informant interviews and informal discussions with irrigators, traditional leaders, earth priests, men, and women. Evidence from analysis revealed that local knowledge enabled farmers to locate groundwater points and determine the source and timing of groundwater recharge. Traditional communities are also able to identify the period for constructing wells. In addition, local knowledge enabled farmers to adopt strategies of conjunctively using groundwater with alternative water to cope with insufficient groundwater resources. We argue that local knowledge serves as a useful tool in sustaining dry season irrigation despite the challenges of a lack of government support and threats of global change.