bluuebunny/crossref_metadata_2025 huggingface dataset:
IMPACT OF DIGITAL TRANSFORMATION OF THE ECONOMY ON THE COMPETITIVENESS OF THE SECTOR OF INFORMATION AND COMMUNICATION TECHNOLOGIES
Authors:   Oles Honchar Dnipro National University, Krasnikova Nataliya , Parkhuts Yevhen ,   Oles Honchar Dnipro National University
Published: October 2023

The article examined the development of the digital economy, we gained an understanding of its main characteristics, key factors of growth and the main directions of digital transformation in the economic sphere of organizations. These results are aimed at improving the quality, efficiency and reliability of information analysis when making management decisions aimed at increasing the innovative capacity of the digital economy and removing obstacles to its transformation. The main focus is on how the latest digital innovations and their application in other industries affect the position of the ICT sector in the market. The authors analyze how digital transformation can become a tool for increasing efficiency and competitive advantages in the field of ICT, as well as what challenges and opportunities arise in this context for representatives of the industry. The results of the study can be useful for entrepreneurs, researchers and government structures interested in the development of information and communication technologies and their role in the modern digital economy. The main findings of our research include a new concept and classification of spheres of activity and ensuring the competitiveness of the digital economy, which divides it into the digital sector and the sector where digital technologies are used. A system of indicators was created to study the development of the digital economy, which is based on international standards of ICT statistics, national accounts, investments and foreign trade. In addition, indicators based on a new classification of spheres of activity in the digital economy were introduced. It was established that the content of the elements of the digital economy can be revealed based on the results of the digital transformation of the economic activity of organizations. This system is divided into five blocks, including ICT indicators, indicators of the specific digital sector, organizations' spending on technology, digital skills of the population and indicators of company transformation. A methodology was also developed for a detailed assessment of the ICT sector, including calculation methods for determining the contribution to various aspects of the digital economy.
ВЗАЄМОДІЯ ЗАКЛАДУ ДОШКІЛЬНОЇ ОСВІТИ ТА СІМ’Ї ЯК ОСНОВА ПЕДАГОГІКИ ПАРТНЕРСТВА
Authors: АЛЕНДАРЬ Надія , СЕМЕНОВА Наталія
Published: October 2023

Роль сім’ї у суспільстві незрівнянна за своєю силою ні з будь-якими іншими соціальними інститутами, адже саме в сім’ї формується і розвивається особистість, відбувається оволодіння нею соціальними ролями, необхідними для щасливого життя в суспільстві. Сім’я є першим мікросередовищем, у якому дитина розвивається, формується, виховується, навчається. У родинному колі створюється природне середовище для фізичного, духовного, інтелектуального, культурного, соціального розвитку дитини, її матеріального забезпечення. Дошкільний вік можна вважати тим періодом у житті дитини, коли вона практично щодня відкриває для себе щось нове та особливо активно пізнає навколишнім світ з його різноманіттям людських відносин, явищ і діяльності дорослих. Проте, соціально-педагогічні дослідження умов сімейного виховання, а також практика роботи сучасних закладів дошкільної освіти переконливо доводять, що батькам необхідна допомога спеціалістів-педагогів, спрямована на підвищення їхньої педагогічної культури, на створення в сім’ї та ЗДО середовища, яке сприяло б емоційному збагаченню дитини, її морально-духовному становленню. Ефективна взаємодія сучасного закладу дошкільної освіти та сім’ї можлива тоді, коли й ті, й інші усвідомлюють, що в них єдина мета – всебічний та гармонійний розвиток дитини. Забезпечити таку взаємодію можливо лише спільними зусиллями на засадах партнерства. У статті аналізуються різні трактування терміну «партнерство». Розглянуті принципи на яких ґрунтується педагогіка партнерства. Охарактеризовані функції, які виконує сучасна сім’я. Описані класичні форми взаємодії закладу дошкільної освіти і сім’ї. Визначено умови ефективного партнерства ЗДО та сім’ї.
APPROACHES TO THE CLASSIFICATION OF STAKEHOLDERS IN REAL ESTATE DEVELOPMENT PROJECTS
Authors:   Prydniprovska State Academy of Civil Engineering and Architecture, Fisunenko Pavlo , Legostaev Ivan ,   Prydniprovska State Academy of Civil Engineering and Architecture
Published: October 2023

The article is devoted to consideration of approaches to classification of stakeholders in real estate development projects. It is noted that real estate development is a new modern concept of real estate development, which is associated with both the creation of new facilities and an increase in the market value of existing ones. It is substantiated that development projects, unlike other investment projects, are distinguished by their characteristic features which make them the most complex, primarily in terms of attracting stakeholders to participate in these projects. The author studies and analyzes the approaches of various authors to the identification of features of stakeholder classification. The existing classifications are grouped by the attributes underlying them. It is established that the implementation of a development project will be more successful the better the interests of the stakeholders of such a project are taken into account in the course of management. It is substantiated that taking into account the classification of development projects and the classification of stakeholders makes it possible to harmonize the individual characteristics of development projects with the interests of stakeholders and provides new opportunities for development in the process of implementing development projects in the modern context of interaction with stakeholders. Having studied various approaches to the classification of stakeholders, it was found that it is possible to establish a link between such a classification and the classification of development projects based on the attribute approach. The list of attributes used in the systematization of stakeholder classifications includes such attributes as: presence and compatibility of relations, relation and necessity, functionality and responsibility, power and legitimacy. The proposed approach greatly simplifies the identification of stakeholders in a development project and allows to increase the efficiency of all participants in the processes of strategic planning, project management and determining the effectiveness of investments.
MANAGEMENT OF TOURISM AND RECREATION DEVELOPMENT AT THE DESTINATION LEVEL
Authors:   Uman National University of Horticulture, Petrenko Natalia
Published: October 2023

Today, despite martial law and the crisis conditions that Ukraine's economy is facing, the tourism business is gradually recovering. In this regard, the country's leadership pays special attention to the formation of separate economic zones of tourist and recreational type and the creation of tourist clusters and destinations. Considering the aforesaid, it is important to provide a scientific justification for the specifics of the implementation of the territorial management system aimed at the development of tourism and regional tourism business. The article considers issues concerning the practice of implementing the methodology for managing the development of tourism and recreational activities at the destination level. The concepts of «tourist and recreational regionalisation» and «tourist and recreational zonation» are studied. In order to study the issue of territorial development and control of regional management processes in the sphere of tourism and recreation, the specific features of regional management processes are investigated on the basis of the methodology of regionalisation and zonation of territory. The article analyses approaches to zonation and regionalisation of tourist and recreational areas. It is specified that the types of tourist and recreational regionalisation and zonation depend on established goals, objectives, and indicators that are determined on the basis of the resource, physical and geographical approaches and socio-economic approaches. The key aspects of implementation of the methodology of regionalisation and zonation of tourist and recreational territories are identified. The approaches to zonation and regionalisation of tourist and recreational areas that have been considered, demonstrate a wide range of tasks that require further investigation and the search for effective solutions. With the purpose of studying the issue of territorial development and control of regional management processes in the sphere of tourism, the specific features of regional management processes have been investigated on the basis of the methodology of regionalisation and zonation of territory. On the basis of the methodology of regionalisation and zonation of the territory, a map of zonation of Cherkasy region by tourist and recreational microdistricts and a schematic map of tourist and recreational microdistricts of the region on the basis of homogeneity and coherence are built.
CURRENT GLOBAL TRENDS OF DIGITALIZATION OF THE CONSUMER FINANCIAL SERVICES INDUSTRY
Authors:   State Tax University, Belinska Yanina , Verheliuk Yuliia ,   State Tax University, Kolyada Olena ,   State Tax University
Published: October 2023

The article examines the digitalization trends of the financial services market in the field of personal consumption. Attention is paid to the spread of various financial services in the field of personal finance management and e-commerce. Examples of foreign financial institutions focused on servicing trade and investment personal financial transactions are given. The specificity of digital technologies makes financial services remote, but their availability is increasing. It is shown that users prefer those banks that provide the opportunity to remotely manage personal accounts and monitor their own financial situation using online platforms and mobile applications. Therefore, the number of digital financial services offered in the field of personal financial transactions becomes a factor in the modern competitiveness of a financial institution. The development of consumer finance (consumer finance) covering operations from investing in real estate to paying for college education is analyzed. Wellplanned consumer finance helps users securely purchase products and services by paying for them in installments over a fixed period of time. The peculiarities of the BNPL industry – "buy now, pay later" – which modernized deferred and installment payments, were studied. BNPL solutions are available in online stores and are immanent for e-commerce. Therefore, the growth of e-commerce sales by 44.4% in 2021 compared to the same year in 2020 stimulated the spread of BNPL's financial services. This increases the competition of firms in this segment of the financial services market. In order to strengthen their competitive positions, the companies offer a number of new approaches to the implementation of BNPL products and solutions. First, they are direct providers of new financial services that are at the heart of BNPL's US solution development. Second, there are facilitators, large payment companies with well-established commercial relationships that seek to capitalize on the growing interest in direct supplier solutions. Third, retroactive suppliers offering different financing options for all purchases made with their credit card after the fact of payment.
FINANCIAL INTERESTS OF BUSINESS ENTITIES DURING THEIR ACTIVITIES
Authors:   Economics and Technology Institute Robert Elworthy, Havrysh Halyna , Frunza Svitlana ,   Economics and Technology Institute Robert Elworthy
Published: October 2023

Balancing and satisfying financial interests are the key tasks of economic entities in the process of conducting financial activities, since the financial reliability and further development of the enterprise depend on it. The purpose of the study is the analysis and systematization of scientific views on the definition of the essence of the concept of "financial interest" and its types, with further clarification of the conceptual and categorical apparatus of the theory regarding financial interests in the activities of economic entities. Method or methodology of the work. The methodological basis of the study were the works of domestic and foreign scientists, who reveal the conceptual and categorical apparatus on financial interest of the enterprise. The method of content analysis, methods of induction and deduction, system method, method of comparative analysis of scientists' works were used in the study. Results of the study. In the research, in accordance with the set purpose, the scientific knowledge about the category of «financial interests» was analyzed and systematized and the author's position in this field was substantiated. The result of the study is a generalization of theoretical ideas in the field of financial interests, that proposed by domestic and foreign scholars, and to develop the author's definition of «financial interests». Approaches to criteria for classification of types of financial interests have also been systematized, and the existing classification has been expanded. Scope of practical application of the results. The obtained results have significant practical value and can be used by business owners and management personnel to improve the development strategy of business entities, as well as in scientific activities when considering questions about the essence and content of the "financial interest" category. Conclusions. The authors conclude, that due to the large number of financial instruments and transactions, the concept of financial interests may have different meanings for different enterprises in the field of finance. Also, depending on the goals and types of financial activity of the enterprise, the types of financial interests also differ.
ANALYSIS OF ITEMS SALE OF FINISHED PRODUCTS OF MEAT PROCESSING ENTERPRISES
Authors:   West Ukrainian National University, Taraban Nazarii
Published: October 2023

The article analyzes the current state of sales of meat products in the world and in Ukraine, finds out the factors that affect the change in the level of sale of meat products, which primarily depend on the preferences of consumers and their financial capabilities. In recent years, global indicators regarding the amount of meat consumption have been growing and, according to the forecasts of representatives of food security in the EU, they will continue to grow until 2032. In recent years, Ukraine has also seen positive changes in the direction of an increase in the production and sale of meat products, despite the full-scale hostilities. Therefore, enterprises of the meat processing industry have great potential for expanding their technological and production capacities. For effective functioning and development, these business entities need to clearly control and optimize costs, especially sales costs. That is why we analyzed the costs of sales of meat products and, on this basis, proposed to separate such costs from the general system of accounting information by relevant articles. Given the fact that today there is not enough stable financial information for the development of enterprises. There is a need for quality, social and environmental indicators, therefore, we consider it appropriate to use the methods described in the article for analyzing the costs of selling meat products, which can be divided into two groups: the first, aimed at forming the correct price policy; the second, aimed at determining forecast data regarding the activities of the meat processing enterprise. Their use will not only make it possible to form the future assortment and quantitative production policy of the enterprise, but will also make it possible to draw up clear budgetary and production plans that will bypass bottlenecks and have optimizing effective indicators. Thus, a detailed diagnosis and analysis of the costs of selling meat products at all levels: local, regional and even outside the country will help meat processing enterprises to achieve a positive effect. To do this, they should choose appropriate methods of analysis that will take into account all the peculiarities of production and sales activities.
DIGITAL TRANSFORMATION AND MANAGEMENT OF THE LOGISTIC FLOW OF THE MILITARY INDUSTRIAL COMPLEX
Authors:   Odesа Polytechnic National University, Shchokina Yevheniia , Chernenko Vitalii ,   Odesa Military Academy
Published: October 2023

The article defines the expediency of digital transformations in the management of logistics flows of the military-industrial complex in the conditions of global digital transformation of the economy and hostilities in Ukraine. The issues of introducing modern digital technologies, tools and a proactive strategy in the logistics sector of the military-industrial complex are considered, taking into account the flexibility of certain aspects of logistics activities, which will improve the digital logistics system in the Armed Forces of Ukraine. The essence of military logistics, digitization in logistics and digital technologies used in digital transformation are revealed. The article presents the main directions of the digitalization process for managing the logistics flows of the military-industrial complex to solve problems related to providing military units with the necessary supplies, obtaining military equipment, humanitarian and financial assistance. It has been determined what the need for digitalization of the transport infrastructure and logistics chains of the military-industrial complex in the conditions of hostilities and constantly changing conditions. A model for managing logistics flows of the military-industrial complex using digital technologies has been developed, connecting all transport and logistics processes and reflecting integrated digital solutions in the logistics of the military-industrial complex. The main tasks of the virtuality of the interaction of transport logistics routes of the Armed Forces of Ukraine are determined. It is noted that digital transformations in the management of logistics flows of the military-industrial complex depend on the effective and organized operation of control subsystems and the virtualization of the interaction environment, which is provided through the use of the global telecommunications environment. The main functions of the logistics flow management system of the military-industrial complex are presented. The specifics of the requirements for the processes of managing the integrated logistics flows of the provision of military units in modern realities are analyzed.
INNOVATIVE APPROACHES TO THE CRAFT BEER MARKET USING SUPPLY LOGISTICS ELEMENTS
Authors:   National University Lviv Polytechnic, Kobylyukh Oksana , Hirna Olha ,   National University Lviv Polytechnic
Published: October 2023

In the article, the essence of the concept of "craft" is disclosed, and its types are presented. The main craft beer producers in Ukraine are outlined, including Varvar, Underwood, "Pravda," "Tsypa," Rebrew, and Brewery 2085. Significant attention is given to the size of investment capital expenditures for equipment procurement, the payback period, and the emphasis is placed not only on production activities but also on logistics, marketing, and distribution channels. It is emphasized that large companies primarily sell their beer in PET bottles through supermarket networks, while craft beer is heavily dependent on HoReCa – mostly sold in kegs to pubs and restaurants. Additionally, along with direct delivery, craft breweries are increasingly developing their network of pubs and bar-shops. An assessment of the feasibility of producing craft beer at PJSC "Carlsberg Ukraine" "Lviv Brewery" is conducted. Considering the positive aspects, the decision to venture into the craft beer business within the operations of this company is made by the authors of the publication. The authors provide a brief overview of craft equipment manufacturers, highlighting the positive and negative elements in their offerings. For further research, three suppliers have been selected: Zip Technologies, Hungary; Integral Geha, Germany; Automationstechnik, Austria. The supplier selection analysis is based on the supply logistics concept and involves evaluating a range of criteria. Given the priority of criteria such as equipment payback period, equipment quality, and its price, additional research on the efficiency of equipment procurement from the three mentioned suppliers is conducted, taking into account the investment amount, depreciation, expected net cash flow, and payback period. As a result of the calculations, Zip Technologies, Hungary is selected with a payback period of 5.7 years and a maximum integrated weighted score of 6.99 among the analyzed suppliers. It is emphasized that the decisive criterion was the payback period, primarily associated with the lower price of production equipment.
Readmission Events Among Patients Who Received ACT Services as Pillar I of SIRUKOGALAR at Mutiara Sukma Mental Hospital
Authors: Lindawati Lindawati , Tsanifiandi Fauzi , ACT Team ACT Team
Published: October 2023

Readmission can occur in all diseases, including in patients with mental disorders where the sufferer experiences problems in the ability to judge reality or which one bad. One of the factors that cause recurrence in patients with mental disorders high emotional level. Another factor is the ability of patients to distinguish between family and hospital staff. In this case, most mental patients are more afraid of hospital staff than their families, so that when patients are allowed to go home the patient no longer follows directions from the family and feels that there is nothing to be afraid of. This caused the patient become not routinely monitored, and prone to experience a relapse. As the first pillar of "SIRUKOGALAR" (Three Communication Pillars Referral System) at Mutiara Sukma Mental Hospital, ACT (Assertive Community Treatment) was used as a comprehensive client-centered mental health program that. This program was carried out to reduce hospitalization, improve the patients’ quality of life, train abilities in fulfilling daily activities, provide support to families and caregivers, reduce symptoms of disability and handle crisis in the community. This study aims to describe the incidence of readmission in patients who get ACT service at the the Mental Health Hospital in 2022. This study is a retrospective study. The data of patients were collected from the medical record from January 2020 to June 2022. The study results show that there is a decrease in the trend of readmission among patients who get ACT services in 2020
Direct Supervision of Daily Consumption of Blood Supplement Tablets During Menstruation Can Increase Adolescent Hemoglobin Levels
Authors: Dewi Depi Susen , Asmawati Asmawati , Buston Erni , Annisa Rahma
Published: October 2023

Consumption of blood supplement tablets (TTD) during menstruation is one effort to prevent anemia. The Ministry of Health recommends taking one tablet supplements weekly and one tablet daily during menstruation. However, adherence of TTD consumption still low among adolescence. The purpose of this study was to determine the effect of direct supervision of tablets consumption on hemoglobin level of adolescent girls. This research is a quasi-experimental with pretest-post-test with control group. Samples are female students of Islamic Boarding School at Bengkulu City. A total sample of 56 female students consisting of 28 intervention group and 28 control group was taken by systematic random sampling. Data were analyzed using t-test. TTD were given every day during menstruation until 2 months. Hemoglobin levels baseline were measured at the first day after menstruation and post HB level were measured at the third month of menstruation. The results showed that the baseline of mean HB in intervention group was 12.2 gr and control group was 12.74 gr and after intervention, the mean of HB increases in intervention group by 1.13 gr and in control group by 0.4 gr. There was a difference in average of hemoglobin levels before and after intervention between the two groups, the difference was 0.79 gr (p 0.000 < α 0.005). Supervision of TTD consumption by the closest person like teacher was important for students, it can promote adherence of TTD consumption, which can increase HB levels and lower anemia among adolescent.
Acute effect of open and closed kinetic chain training on lower limb muscle strength in young adults
Authors: Reis Carlos Brendo Ferreira , Teixeira Gabrielle Lopes , Santos Matheus Jonas , Araújo Vieira Leonardo , Rinaldi Natalia Madalena
Published: October 2023

Among training prescription variations for improving muscle strength, we can highlight open kinetic chain (OKC) and closed kinetic chain (CKC) exercises. The aim of this study was to investigate the acute effect of OKC and CKC exercises on lower limb muscle strength in young adults. Subjects were invited to participate in an acute training consisting of three OKC exercises and three CKC exercises and performed three sets of ten repetitions. To evaluate the torque and muscle power, an isokinetic dynamometer and a force platform were used. The analyzed variables were: peak of torque, time to peak torque, mean power and average power. Univariate analyses were used to compare the performance of participants in OKC and CKC exercises in torque and power tests. Peak torque was higher in the extensor and plantar flexion movements than knee and ankle joints, respectively. When comparing OKC and CKC exercises, OKC exercises produced a higher peak of torque and mean power in all the joints than CKC. We concluded that OKC exercises can be used for improving strength in young adults.
Preditores da laserterapia de alta e baixa intensidade em pacientes com úlcera do pé diabético: uma revisão sistemática
Authors: Nascimento Iramar Baptistella do , França Maria Elisa Duarte , Fleig Raquel
Published: October 2023

Introdução: As ulceras de pé diabético tornou-se um dos principais problemas após o diagnóstico da doença e a cicatrização das feridas são desafios a serem superados. Objetivos: Verificar se os preditores da laserterapia de alta e baixa intensidade podem ser considerados de indicação primária para a seleção dos tratamentos de úlceras de pés diabéticos. Métodos: Revisão sistemática nas bases PubMed/Medline, Web of Science, Scopus, Lilacs. Utilizou-se o cheklist PRISMA e, para o risco de viés, o Banco de Dados de Evidência Fisioterápica (PEDro). Resultados: Identificou-se a importância do comprimento da onda no processo de regeneração tecidual e granulação, com a possibilidade de variações quando em terapia laser de baixa intensidade, mas com alta intensidade, não deve haver variações. Conclusão: A laserterapia pode ser de indicação primária visto que oportuniza um menor tempo de cicatrização e sugere-se o uso de ambas as irradiações de alta e baixa intensidade no período de no mínimo 4 e máximo 15 semanas, de 2-4 J/cm2 com 660 nm e, dosagem fixa de 10 J/cm2 com 660 nm, de forma que não ocorram exposições múltiplas quando em radiações de alta intensidade, uma vez que diferentes dosagens de alta intensidade pode inibição a proliferação celular.
Atuação fisioterapêutica nos déficits de cognição e incapacidades funcionais em pacientes com doença de Alzheimer: uma revisão integrativa
Authors: Silva Francisco Valter Miranda , Rabelo Francisco Felipe Cardozo , Ferreira Rosana Iorio , Silva Jacqueline Aguiar da , Magalhães Sobrinho Davy Deusdeth Timbó , Silva Lindolfo Jorge Magalhães , Guedes Jéssica Pereira , Costa Letícia Ellen Correia , Lima Luciana Silva , Nunes Paula Pessoa de Brito
Published: October 2023

Objetivo: Revisar a literatura científica e evidenciar a atuação fisioterapêutica nos déficits de cognição e incapacidades funcionais em pacientes com Doença de Alzheimer (DA). Métodos: Realizou-se uma revisão integrativa da literatura. A busca de artigos ocorreu de setembro a dezembro de 2021, nos portais/bases de dados eletrônicos: Medline/PubMed, Physiotherapy Evidence Database (PEDro), Scientific Eletronic Library Online (SciELO) e Biblioteca Virtual em Saúde (BVS), utilizando descritores indexados (Alzheimer Disease e Physical therapy). Foram incluídos artigos publicados entre 2011 e 2021, do tipo observacional ou intervenção, nos idiomas inglês, português e espanhol. Excluíram-se editoriais, relatos de casos, revisões e teses/dissertações. Resultados: Foram encontrados 293 artigos, deste total, foram incluídos 8 artigos. A atuação fisioterapêutica apresentou-se como uma boa opção de tratamento para os pacientes com DA, sendo os exercícios aeróbicos os mais utilizados. Os exercícios funcionais e de dupla tarefa, treino de memória, equilíbrio, treinamento em circuito orientado a tarefas progressivo e coordenação motora também são mencionados na literatura. Os pacientes que se encontravam na fase inicial da doença ao serem submetidos ao programa fisioterapêutico apresentaram uma redução significativa dos distúrbios neuropsiquiátricos, além de uma maior interação social e manutenção da capacidade funcional. Conclusão: Diante dos resultados, evidenciou-se que a atuação fisioterapêutica contribui para a manutenção da capacidade funcional e retardo dos déficits de cognição em pacientes com DA.
Effects of ozone therapy on joint rehabilitation in patients with osteoarthritis: a systematic review
Authors: Cordeiro André Luiz , Barbosa Priscilla Abreu , Araújo Lays Brito Dias de
Published: October 2023

Introduction: Osteoarthritis is a comorbidity of chronic and multifactorial pain, characterized by a degenerative joint process that compromises functionality. Ozone therapy has proven to be a good rehabilitation strategy in view of its regenerative and antioxidant effects. Objective: To describe the effects of ozone therapy on tissue recovery, with regard to pain and functionality, impacting the joint rehabilitation of patients with osteoarthritis. Methods: Refers to a systematic review guided by the PICO strategy, the search was performed in the Lilacs, Pubmed, and Central databases, with the descriptors: osteoarthritis, degenerative arthritis, cartilage, damaged cartilage, arthritis, joint, ozone, ozone therapy, ozone therapy, ozone injection, pain, arthralgia, chronic pain, joint pain, mobility, mobility limitation, range of motion and functionality, using the Boolean operators "AND" and "OR", including articles from 2016 to 2021. Results: After reading the title and abstract, 40 studies were found, 5 were selected according to the inclusion criteria, which showed that ozone therapy is effective in joint rehabilitation for pain and functionality markers. However, with differences in duration of effects when compared to other therapies, being more effective in the short term. Conclusion: Ozone therapy is effective in reducing pain and inflammation, and in functional improvement, directly impacting the joint rehabilitation of patients with osteoarthritis.
URGENSI PELIBATAN DAN PARTISIPASI MASYARAKAT DALAM PENGAWASAN PENYELENGGARAAN PEMILU SERENTAK TAHUN 2024
Authors: Dairani  , Islami Trinah Asi
Published: October 2023

Simultaneous elections in 2024 will soon take place, this is marked by the start of several election stages starting from the formation of election commissions/organizers to the drawing of serial political party numbers. The holding of democratic elections in accordance with the principles of elections is a must to be realized, especially in the simultaneous elections in 2024. So that concrete efforts are needed in monitoring, overseeing and supervising and supporting stages by stages in the implementation of elections. Constitutionally, Bawaslu is an institution whose job is to supervise the implementation of elections. However, the involvement and participation of the public/community in terms of monitoring the implementation of elections is important to do by looking at the form, number and characteristics of massive and systematic violations. Public involvement is a constitutional right in overseeing and giving control over the holding of democratic elections in order to ensure people's sovereignty in the holding of elections. There are several important and crucial stages in the election stage, namely the collection of voter list data which is often found by fictitious voters and unregistered voters and the second crucial stage is the implementation of voting in the field. The 2024 simultaneous elections will be more complicated and take up a lot of time and energy so that the existence and involvement of the public/community in terms of oversight and monitoring functions is absolutely necessary in order to assist the Bawaslu in carrying out its duties and functions so that quality elections can be created with intelligent voters by being able to suppress and minimize the number of election violations.
A glimpse of the “new normal” in online language learning and teaching
Authors: Arciaga Kasumi
Published: October 2023

The Covid-19 pandemic has significantly promoted online foreign language learning and teaching, given in the situation of the widespread lockdowns globally. Most of Southeast Asian countries took harsher approach to the pandemic. In the context of the Philippines, where in-person school operations were prohibited for a continuous period of 20 months, the impact of these restrictions has been unmistakable. This study aims to explore and highlight the experiences of online language learners and teachers during the Covid-19 pandemic. Research in this area remains limited due to the recent conclusion of the pandemic.
In the present study, eight foreign language teachers participated in the focus groups, and eight language learners took part in one-on-one interviews. Through thematic analysis, the findings of this study unveiled a notable trend, which are that learners exhibited a strong preference for online classes, while teachers expressed an equitable preference for both online and face-to-face instruction. This divergence in preferences signifies a dynamic shift in the landscape of language education. The study therefore concludes that the "new normal" of language learning and teaching has indeed materialized during the pandemic, as evidenced by the transformative shift towards online modes of instruction.
Peter Bell’s Professions
Authors: Simons Christopher
Published: October 2023

This article investigates the socioeconomic contexts of Wordsworth’s Peter Bell in relation to Peter’s ‘profession’ – to use Wordsworth’s term, when he wrote that first among the ‘great defects’ of Coleridge’s Ancient Mariner is that the protagonist ‘has no distinct character … in his profession of Mariner’. Peter Bell is a ‘potter’; Wordsworth’s footnote to the 1819 first edition defines this as ‘a hawker of earthenware’. Modern scholarship accepts the northern definition of potter as ‘pedlar’, effacing the connection to pottery. Yet evidence in the poem suggests that Wordsworth understood the socioeconomic contexts of the poem’s Swaledale setting in 1798–1800, with particular knowledge of the area’s role as the heart of Britain’s lead-mining industry. Peter’s presence in Swaledale links him, through his ‘professions’, to lead mining in the Pennines; and through lead mining, to the Staffordshire pottery industry and Wordsworth and Coleridge’s friends and patrons, Tom Wedgwood and Josiah Wedgwood II.
β-TCP from 3D-printed composite scaffolds acts as an effective phosphate source during osteogenic differentiation of human mesenchymal stromal cells
Authors: Hatt Luan P. , van der Heide Daphne , Armiento Angela R. , Stoddart Martin J.
Published: October 2023

Introduction: Human bone marrow-derived mesenchymal stromal cells (hBM-MSCs) are often combined with calcium phosphate (CaP)—based 3D-printed scaffolds with the goal of creating a bone substitute that can repair segmental bone defects. In vitro, the induction of osteogenic differentiation traditionally requires, among other supplements, the addition of β-glycerophosphate (BGP), which acts as a phosphate source. The aim of this study is to investigate whether phosphate contained within the 3D-printed scaffolds can effectively be used as a phosphate source during hBM-MSC in vitro osteogenesis.

Methods: hBM-MSCs are cultured on 3D-printed discs composed of poly (lactic-co-glycolic acid) (PLGA) and β-tricalcium phosphate (β-TCP) for 28 days under osteogenic conditions, with and without the supplementation of BGP. The effects of BGP removal on various cellular parameters, including cell metabolic activity, alkaline phosphatase (ALP) presence and activity, proliferation, osteogenic gene expression, levels of free phosphate in the media and mineralisation, are assessed.

Results: The removal of exogenous BGP increases cell metabolic activity, ALP activity, proliferation, and gene expression of matrix-related (COL1A1, IBSP, SPP1), transcriptional (SP7, RUNX2/SOX9, PPARγ) and phosphate-related (ALPL, ENPP1, ANKH, PHOSPHO1) markers in a donor dependent manner. BGP removal leads to decreased free phosphate concentration in the media and maintained of mineral deposition staining.

Discussion: Our findings demonstrate the detrimental impact of exogenous BGP on hBM-MSCs cultured on a phosphate-based material and propose β-TCP embedded within 3D-printed scaffold as a sufficient phosphate source for hBM-MSCs during osteogenesis. The presented study provides novel insights into the interaction of hBM-MSCs with 3D-printed CaP based materials, an essential aspect for the advancement of bone tissue engineering strategies aimed at repairing segmental defects.
Bacterial outer membrane vesicles bound to bacteriophages modulate neutrophil responses to bacterial infection
Authors: Pennetzdorfer Nina , Popescu Medeea C. , Haddock Naomi L. , Dupuy Fannie , Kaber Gernot , Hargil Aviv , Johansson Patrik K. , Enejder Annika , Bollyky Paul L.
Published: October 2023

Pseudomonas aeruginosa is a major human pathogen, particularly effective at colonizing the airways of patients with cystic fibrosis. Bacteriophages are highly abundant at infection sites, but their impact on mammalian immunity remains unclear. We previously showed that Pf4, a temperate filamentous bacteriophage produced by P. aeruginosa, modifies the innate immune response to P. aeruginosa infections via TLR3 signaling, but the underlying mechanisms remained unclear. Notably, Pf4 is a single-stranded DNA and lysogenic phage, and its production does not typically result in lysis of its bacterial host. We identified previously that internalization of Pf4 by human or murine immune cells triggers maladaptive viral pattern recognition receptors and resulted in bacterial persistence based on the presence of phage RNA. We report now that Pf4 phage dampens inflammatory responses to bacterial endotoxin and that this is mediated in part via bacterial vesicles attached to phage particles. Outer membrane vesicles (OMVs) are produced by Gram-negative bacteria and play a key role in host pathogen interaction. Recently, evidence has emerged that OMVs differentially package small RNAs. In this study, we show that Pf4 are decorated with OMVs that remain affixed to Pf4 despite of purification steps. These phages are endocytosed by human cells and delivered to endosomal vesicles. We demonstrate that short RNAs within the OMVs form hairpin structures that trigger TLR3-dependent type I interferon production and antagonize production of antibacterial cytokines and chemokines. In particular, Pf4 phages inhibit CXCL5, preventing efficient neutrophil chemotaxis in response to endotoxin. Moreover, blocking IFNAR or TLR3 signaling abrogates the effect of Pf4 bound to OMVs on macrophage activation. In a murine acute pneumonia model, mice treated with Pf4 associated with OMVs show significantly less neutrophil infiltration in BAL fluid than mice treated with purified Pf4. These changes in macrophage phenotype are functionally relevant: conditioned media from cells exposed to Pf4 decorated with OMVs are significantly less effective at inducing neutrophil migration in vitro and in vivo. These results suggest that Pf4 phages alter innate immunity to bacterial endotoxin and OMVs, potentially dampening inflammation at sites of bacterial colonization or infection.
Ixodes scapularis nymph saliva protein blocks host inflammation and complement-mediated killing of Lyme disease agent, Borrelia burgdorferi
Authors: Bencosme-Cuevas Emily , Kim Tae Kwon , Nguyen Thu-Thuy , Berry Jacquie , Li Jianrong , Adams Leslie Garry , Smith Lindsey A. , Batool Syeda Areeha , Swale Daniel R. , Kaufmann Stefan H. E. , Jones-Hall Yava , Mulenga Albert
Published: October 2023

Tick serine protease inhibitors (serpins) play crucial roles in tick feeding and pathogen transmission. We demonstrate that Ixodes scapularis (Ixs) nymph tick saliva serpin (S) 41 (IxsS41), secreted by Borrelia burgdorferi (Bb)-infected ticks at high abundance, is involved in regulating tick evasion of host innate immunity and promoting host colonization by Bb. Recombinant (r) proteins were expressed in Pichia pastoris, and substrate hydrolysis assays were used to determine. Ex vivo (complement and hemostasis function related) and in vivo (paw edema and effect on Bb colonization of C3H/HeN mice organs) assays were conducted to validate function. We demonstrate that rIxsS41 inhibits chymase and cathepsin G, pro-inflammatory proteases that are released by mast cells and neutrophils, the first immune cells at the tick feeding site. Importantly, stoichiometry of inhibition analysis revealed that 2.2 and 2.8 molecules of rIxsS41 are needed to 100% inhibit 1 molecule of chymase and cathepsin G, respectively, suggesting that findings here are likely events at the tick feeding site. Furthermore, chymase-mediated paw edema, induced by the mast cell degranulator, compound 48/80 (C48/80), was blocked by rIxsS41. Likewise, rIxsS41 reduced membrane attack complex (MAC) deposition via the alternative and lectin complement activation pathways and dose-dependently protected Bb from complement killing. Additionally, co-inoculating C3H/HeN mice with Bb together with rIxsS41 or with a mixture (rIxsS41 and C48/80). Findings in this study suggest that IxsS41 markedly contributes to tick feeding and host colonization by Bb. Therefore, we conclude that IxsS41 is a potential candidate for an anti-tick vaccine to prevent transmission of the Lyme disease agent.
Three decades of glacial lake research: a bibliometric and visual analysis of glacial lake identification
Authors: Liu Zhengquan , Yang Zhiquan , He Na , Wei Lai , Zhu Yingyan , Jiao Wenqi , Wang Zhengxian , Zhang Tao , Zhang Jiantao , Zou Xiang
Published: October 2023

Introduction

As a vital component within glacier systems, the occurrences of glacial lake disasters in high mountain regions have progressively emerged as one of the most destructive natural calamities amid the backdrop of global warming. The swift advancement of glacial lake identification techniques offers a pivotal perspective for forecasting and mitigating the perils of glacial lake outburst disasters.

Methods

To evaluate the thematic evolution, research focal points, and forthcoming directions within the glacier identification domain, a comprehensive bibliometric analysis was conducted on glacial lake identification-related literature from 1991 to 2023 in the Web of Science Core Collection database.

Results

1) The United States, the United Kingdom, and China stand as principal nations propelling the field's advancement. The Chinese Academy of Sciences demonstrates the highest activity in terms of article publications and international collaborations. 2) Climate change, compilation of glacial lake inventories, methodologies for risk assessment, glacial lake outburst floods, comprehensive disaster management strategies, and hydrodynamic models constitute the domain's research hotspots. It is a typical multidisciplinary field. 3) Persistently high-impact topics over an extended period include “hazard”, “Late Pleistocene”, “environmental change”, “ice sheet”, and “lake sediments”. Keywords indicating the present cutting-edge research encompass “inventory”, “glacial lake outburst flood”, “risk”, “dynamics”, “Tibetan Plateau”, “evolution”, and “high mountain Asia”.

Discussion

This paper delves into the current status and pivotal concerns of glacial lake identification techniques, methodologies, and the scale of identification research themes. Further Research should concentrate on avenues like “recognition methods grounded in machine learning and deep learning”, “multisource data fusion datasets”, “novel algorithms and technologies adaptable to scale transformation and data expansion”, as well as “enhancing spatiotemporal data resolution”. This will ultimately enable precise, prolonged, and multiscalar identification of glacial lakes. his study provides valuable guidance and reference for future research in the field of glacial lake identification.
Ancient duplication, coevolution, and selection at the MHC class IIA and IIB genes of birds
Authors: Minias Piotr , Edwards Scott V. , Babik Wiesław
Published: October 2023

Introduction

The Major Histocompatibility Complex (MHC) of vertebrates is a dynamically evolving multigene family primarily responsible for recognizing non-self peptide antigens and triggering a pathogen-specific adaptive immune response. In birds, the MHC was previously thought to evolve via concerted evolution with high degree of gene homogenization and the rapid loss of orthology. However, the discovery of two ancient avian MHC-IIB gene lineages (DAB1 and DAB2) originating before the radiation of extant birds indicated that despite the action of concerted evolution, orthology may be detectable for long evolutionary periods.

Methods

Here, we take advantage of rapidly accumulating digital genomic resources to search for the signal of an ancient duplication at the avian MHC-IIA genes, as well as to compare phylogenetic distribution and selection between MHC-IIA and IIB gene lineages.

Results

The analysis of MHC sequences from over 230 species representing ca. 70 bird families revealed the presence of two ancient MHC-IIA gene lineages (DAA1 and DAA2) and showed that their phylogenetic distribution matches exactly the distribution of DAB1 and DAB2 lineages, suggesting tight coevolution. The early post-duplication divergence of DAA1 and DAA2 was driven by positive selection fixing radical amino acid differences within the membrane-proximal domain and, most probably, being functionally related to the interactions between α2 and β2 chains of the MHC-II heterodimer. We detected no evidence for an overall (gene-wide) relaxation or intensification of selection at either DAA1/DAB1 or DAA2/DAB2, but codon-specific differences in selection signature were found at the peptide-binding sites between the two gene lineages, perhaps implying specialization to different pathogen regimes.

Discussion

Our results suggest that specific pairing of MHC-II α and β chains may have an adaptive significance, a conclusion that advances knowledge on the macroevolution of the avian MHC-II and opens exciting novel directions for future research.