bluuebunny/crossref_metadata_2025 huggingface dataset:
An 11-Year-Old Girl With Rare Diagnosis of Meier-Gorlin Syndrome Accompanied by Neonatal Seizure, Mental Retardation, and Attention Deficit Hyperactivity Disorder: A Case Report and Review of Literature
Authors: Koomanaee Shahin , Dalili Setila , Hoseini Nouri Seyyedeh Azade , Jalali Seyedeh Zohreh , Tabrizi Manijeh , Aldaghi Ghazaleh , Hassanzadeh Rad Afagh
Published: November 2022

Meier-Gorlin syndrome (MGS) is a rare autosomal recessive disorder with homozygous or heterozygous mutations in one of the five following genes (ORC1, ORC4, ORC6, CDT1, and CDC6). This syndrome is characterized by the triad of short stature (pre/postnatal), microtia, and patella hypoplasia/aplasia. Special features included microcephaly, microstomia, full lips, micrognathia, narrow convex, and high nasal bridge nose. Also, it may be accompanied by feeding problems, skeletal disorders, urogenital or respiratory anomalies, and intelligence disorders. This case report describes the first Persian MGS accompanied by neonatal seizure, mental retardation, and attention deficit hyperactivity disorder.
Post-antifungal effect of the combination of anidulafungin with amphotericin B and fluconazole against fluconazole-susceptible and -resistant Candida albicans
Authors: Vaseghi Narges , Piramoon Majid , Khojasteh Shaghayegh , Abbasi Kiana , Mohseni Sahar , Javidnia Javad , Naghili Behrooz , Aslani Narges
Published: November 2022

Background and Purpose: Invasive candidiasis is a life-threatening condition that kills a large number of immunocompromised patients each year worldwide. We used postantifungal effect studies to analyze the activities of anidulafungin (AFG), as a clinically crucial antifungal drug, amphotericin B (AMB), and fluconazole (alone and in combinations) against FLC-susceptible and -resistant Candida albicans (C. albicans) isolates obtained from the cancer patients.
Materials and Methods: We tested the phenomenon of post antifungal effects of FLC, AMB, AFG, and combinations of FLC+AFG, AFG+AMB, and FLC+AMB against 17 C. albicans isolates obtained from the oral cavity of cancer patients. Isolates that had not been exposed to antifungals, served as a control group. Colony counts were performed at 0, 2, 4, 6, and 24 h after a brief (1 h) exposure to antifungal.
Results: The FLC had no detectable post-antifungal effect independent of antifungal concentration and resembled drug-free FLC (control). Significant variations in the postantifungal effect were observed when all AMB and AFG were compared to FLC. The combination of AFG and AMB with FLC resulted in effective activity compared to FLC alone. Combination regimens were rated as indifferent in general. Interestingly, low dosages of the AFG displayed increasing fungistatic action as it approached a fungistatic endpoint against C. albicans isolates (n=17).
Conclusion: Our findings suggested that brief exposure to AFG, in combination with FLC and AMB, at low concentrations of the medicines utilized, could be effective in the evaluation and optimization of new dosage regimens to manage candidiasis. However, future studies will determine the clinical utility of our findings.
Invasive pulmonary aspergillosis in critically Ill patients with pneumonia due to COVID-19, influenza, and community- acquired pneumonia: A prospective observational study
Authors: Ali Syed Ahsan , Jabeen Kausar , Farooqi Joveria , Niamatullah Hammad , Siddiqui Aisha Fareed , Awan Safia , Akbar Alishah , Irfan Muhammad
Published: November 2022

Background and Purpose: Influenza A and SARS-CoV-2 are risk factors for invasive pulmonary aspergillosis. Both influenza-associated pulmonary aspergillosis and COVID-19- associated pulmonary aspergillosis result in high mortality and poor clinical outcomes. No prospective study has so far compared the features, treatment, and outcomes of influenza-associated pulmonary aspergillosis and COVID-19-associated pulmonary aspergillosis within a similar time frame. Therefore, this study aimed to determine the frequency, risk factors, and outcomes of invasive pulmonary aspergillosis in critically ill patients with influenza, COVID-19, and community-acquired pneumonia.
Materials and Methods: This prospective study included adult patients with pneumonia and was conducted at The Aga Khan University Hospital in Karachi, Pakistan. Patients were divided into three groups, including community-acquired pneumonia, influenza pneumonia, and COVID-19 pneumonia. The data collected included information on demographic characteristics, comorbidities, clinical features, laboratory results, treatment, and outcomes.
Results: A total of 140 patients were included in this study. These included 35 (25%), 70 (50%), and 35 (25%) patients with community-acquired pneumonia, influenza pneumonia, and COVID-19 pneumonia, respectively. In addition, 20 (14.2%) patients were found to have invasive aspergillosis, of whom 10/35 (28.5%), 9/70 (12.8%), and 1/35 (2.8%) patients were in the COVID-19, influenza, and community-acquired pneumonia groups, respectively. Moreover, nine (90%) COVID-19-associated pulmonary aspergillosis patients required vasopressors, compared to three (33%) patients with influenza-associated pulmonary aspergillosis (P=0.020). In total, seven (70%) COVID-19-associated pulmonary aspergillosis patients required invasive mechanical ventilation compared to four (44%) influenza-associated pulmonary aspergillosis patients (P=0.37). The mean±SD length of hospital stay was highest in the COVID-19-associated pulmonary aspergillosis patients (18.3±7.28 days) compared to influenza-associated pulmonary aspergillosis patients (11.7±5.34 days) (P=0.036). The number of deaths in influenza-associated pulmonary aspergillosis and COVID-19-associated pulmonary aspergillosis patients was three (33.3%) and five (50%), respectively (P=0.526).
Conclusion: A higher proportion of patients with COVID-19 developed invasive aspergillosis compared to those with influenza. Although the mortality rate in COVID19-associated pulmonary aspergillosis was comparable to that in influenza-associated pulmonary aspergillosis patients, COVID-19-associated pulmonary aspergillosis patients had a significantly longer stay in the hospital.
Pulmonary tuberculosis and rhinosinus mucormycosis coinfection in a diabetic patient
Authors: Shabani Shiva , Tabarsi Payam , Afzal Golnaz
Published: November 2022

Background and Purpose: Diabetes and immunosuppressive diseases have been reported as increased risk factors for developing invasive pulmonary tuberculosis and mucormycosis.
Case report: We presented here a case of a 55-year-old uncontrolled diabetic male with rhinosinus mucormycosis and pulmonary TB coinfection. Maxillary and ethmoid sinus involvement was observed in paranasal computed tomography. His chest computed tomography showed tree in the bud sign and cavitary lesions in the lungs. Mycobacterium tuberculosis was confirmed through molecular diagnosis using a realtime polymerase chain reaction assay. The nasal cavity biopsy revealed the fungal elements (aseptate hyphae) and confirmed mucormycosis infection. Amphotericin B liposomal, teicoplanin, and tazobactam were administered to treat the mucormycosis. The patient was successfully treated with a recommended four-drug regimen for TB without any adverse reaction.
Conclusion: The clinicians must consider tuberculosis and mucormycosis tests when confronted with an uncontrolled diabetic patient with clinical symptoms of hemoptysis, fever, and cavitary lesions.
Evaluation the effect of maxillary protraction on the airway dimensions: a review
Authors: Mirhashemi Seyyed Amirhossein , Ghadirian Hannaneh , Bahrami Rashin
Published: November 2022

Aim and Objective:  The aim of this study was to evaluate the effect of maxillary protraction on airway dimensions in growing patients.
Method and material: The research was conducted using literature reviews. Articles included in databases such as PubMed, Embase, Google Scholar and Cochrane were reviewed via inputting keywords such as maxillary protraction, maxilla retrusion, retrognathic, class III malocclusion, face mask, reverse head gear, Delaire, protraction head gear, reverse occlusion, anterior crossbite, growing patient, bone anchorage, dental anchorage. The search period for articles ranged from January 2005 to April 2021.
Results:7 articles with inclusion criteria were included in the study; the results of the studies showed the effectiveness of maxillary protraction on increasing the dimensions of the airway. Studies have shown a significant increase in the size of the upper airway, especially the nasopharynx, following maxillary protraction with tooth-borne and bone-borne appliances.
Conclusion: Maxillary protraction can increase the size of the upper airway in growing patients. However, further studies are needed to elucidate the effects on changes in the pharyngeal airway, respiratory indicators (such as the apnea-hypopnea index), and its long-term effects.
Evaluation the histopathological findings of oral lesions in patients referred to the pathology department of Semnan city (Iran)
Authors: Mirmohammadkhani Majid , Tofighian Marjan , Mansori Kamyar , Mirmohammadkhani Omid
Published: November 2022

Background: The aim of this study was to evaluate the histopathological findings of oral lesions in patients referred to the pathology department of Kosar Hospital of Semnan city (Iran) in 2012-2018.
Materials and Methods: This population-based cross-sectional study was concocted on the histopathological findings of oral lesions 137 patients referred to the pathology department of Kosar Hospital of Semnan city (Iran) in 2012-2018. The sampling method was census. The data collection tool was a check including demographics and dentistry (type of dental lesion, location of the lesion, malignancy of lesions, origin of dental lesions, side of the lesion conflict, jaw involved, anterior-posterior position and type of biopsy). SPSS24 was used for data analysis and a signifi- cance level of less than 0.05 was considered.
Results: The most common type and the most common location of oral lesions were periapical cyst (16.7%) and periapical (28.3%); respectively. The most common sources of oral lesions were related to inflammation and connective tissue with 27.5 and 26.8%, respectively. Mandible (47.8%) was the most common involved jaw and 5.1% of reported lesions were malignant. In addition, the prevalence of periapical cyst (78.3 vs. 21.7%) and pyogenic granuloma (82.4 vs. 17.6%) were significantly higher in women than men (P-Value=0.035).The highest rates of periapical cyst (43.5%) and pyogenic granuloma (58.5%) were observed in the age group ≤30 and 31-40 years; respectively (P-Value=0.013).
Conclusion: This study suggests that the female patients and over 40 years should be more careful to check for periapical cyst. However, more detailed studies with higher sample sizes are recommended.
Comparison of cognitive strategies for emotion regulation, impulsivity and suicidal ideation in people with obsessive-compulsive disorder, bipolar people disorder and normal people
Authors: Beheshti Niloofar , Najafi Mahmoud
Published: November 2022

Aim: The aim was to compare cognitive strategies for emotion regulation, impulsivity, and suicidal ideation in patients with obsessive-compulsive, bipolar disorder and normal individuals.
Methods: This was a causal-comparative study. The statistical population included people who were diagnosed with obsessive-compulsive disorder and bipolar disorder in city of Semnan, Iran in the year 1400.  According to the opinion of a psychiatrist, as well as normal people who were not diagnosed with a disorder based on self-report and using a checklist of symptoms of mental disorders. Fifty obsessive-compulsive patients and 50 bipolar patients, as well as 50 normal individuals were selected through available sampling. Granfsky Emotion Cognitive Regulation Questionnaire, Barthes Impulsivity, and Beck Suicidal Thought were administered. Multivariate analysis of variance was used to analyze the data.
Findings: Cognitive regulation of emotion, impulsivity and suicidal ideation are significantly different in the three groups. The mean scores of the patient group were higher than the normal group in the negative components of emotion regulation, impulsivity and suicidal ideation (p<0.05). In the positive of emotion regulation, the mean scores of the bipolar group were higher than the obsession (p<0.05). In negative regulating emotion, the mean scores of obsessive-compulsive patients were higher than those of bipolar disorder (p<0.05). Also, the mean scores of obsessive-compulsive group was higher than bipolar in cognitive impulsivity (p<0.05 ); but there was no difference between the obsessive-compulsive and bipolar groups in motor components and lack of planning (p>0.05).
Conclusion: Holding educational workshops to minimize the damage caused by failure in emotion regulation, impulsivity, and suicidal thoughts in obsessive-compulsive and bipolar disorder sufferers, designing support programs such as training impulse management skills, using adaptive emotion regulation strategies, planning skills and decision-making in the general population as well as obsessive-compulsive and bipolar patients, as well as the appropriate treatment plan to prevent the exacerbation or recurrence of patients' symptoms can be effective.
Influence of covid-19 in the training and academic learning of students at Peleforo GON COULIBALY University of Korhogo (Ivory Coast).
Authors: Silue Donakpo , Taiba Germaine AINYAKOU , Nahoua Adama SORO
Published: November 2022

UNESCO noted in 2020 that 85% of pupils and students in 165 countries are no longer in school because of COVID-19. Indeed, this disease has had several social consequences around the world. One of these is the academic component. In addition, the world has been exploring new methods of teaching and learning at a distance. This method, although innovative, has impacts on the university, the teacher and the student. Hence the need to question the impact of the Covid-19 in university training and learning, particularly at the Peleforo GON COULIBALY University (UPGC). To achieve this, a socio-anthropological study was conducted using a qualitative approach. Its purpose was to describe the impact of the health crisis on the student population of the UPGC. It took place from 10 July to 7 September 2021 in Korhogo, Ivory Coast, specifically at the UPGC. The collection tools were individual interviews and documentary research. According to rational choice sampling, 63 students and 8 members of the various examination commissions, i.e. 71 people in total, were mobilised.

The results reveal that the duration of social distancing has created a sense of isolation for some UPGC students and lost learning time. In addition, the change in assessment procedures has led to a series of problems such as postponed or cancelled exams in some departments and in others replaced by group exercises or individual homework. Also, the use of NICTs to communicate and acquire knowledge has been intense during this health crisis, which could stimulate risks of visual disorders among students and teachers. Thus, the covid-19 crisis not only impacted on students' learning time, but also on the biology and quality of the knowledge received during this period
Extent of implementation of smoking ban among Senior High School students in Zambales, Philippines
Authors: Balangon Mary Jane , Dantic Marshall James
Published: November 2022

ABSTRACT

The Department of Education, Zambales Division is also adopting anti-smoking measures in accordance with the above Deped guidelines and rules. Consequently, this study would assess the extent to which smoking ban was implemented among senior high school. The study utilizes descriptive research design where survey checklist was the main instrument to gather data. The study was conducted in Zone 2, Division of Zambales which consisted of municipalities of Palauig, Iba and Botolan. The study used simple random sampling. There are five hundred twenty seven (527) senior high school students from different municipalities have served as respondents. The instrument was validated by three experts and treated through reliability testing. There are two parts of the instrument, (a) demographic profile of the respondents; (b) perception of the student-respondents towards extent of smoking ban implementation. Based from the results, therefore it conclude that the student-respondents assessed “Implemented” on the level of smoking ban implementation as to school policies and intervention, teachers’ participation and students’ participation respectively; that there is significant difference when grouped according all profile variables except for gender as to school policies and intervention and students’ participation; and that there is no significant differences on the assessment towards dimensions on the level of extent of implementation of smoking ban as to school policies and intervention, teachers and student participation respectively.
An Analysis of the Effective Ways to Improve Citizen Participation in Public Policy Making in China
Authors: Liu Jianwen
Published: November 2022

Citizens' participation in the formulation of government public policies is an important way for citizens to participate in decision-making. The article examines citizen participation in the process of public policy making in China, pointing out the new trend of citizen participation and identifying some problems of citizen participation, such as insufficient motivation of citizen participation and the prevalence of extra-institutional participation. The reasons for these problems are analyzed in depth and countermeasures are proposed, such as improving the relevant legal system and increasing the supervision and feedback of the policy-making process
The effect of Green Supply Chain management on Environmental Performance: Evidence from Bangladesh
Authors: Alauddin Md. , Arif Md. Iftekhar
Published: November 2022

This study aims to examine the relationship between green supply chain management (GSCM) practices and environmental performance (ENP) in Bangladesh's manufacturing industry. Data were gathered from 220 managers using survey methods. The results show that GSCM techniques have a beneficial impact on ENP. The findings also show a strong correlation between green marketing and ENP. Additionally, this study will support the implementation of GSCM methods by supply chain managers, policy makers, and practitioners in order to enhance ENP. The implications of GSCM are examined, along with suggestions for further study.
Korea in the Kamiyo: Locating Korea in the Age of the Gods Narratives in Early Modern Japan
Authors: Cho Ilsoo
Published: November 2022

Early modern Japan witnessed new and unprecedented debates surrounding ancient history, including a school of thought that suggested a significant Korean influence upon ancient Japan. This line of thought contrasted sharply with the contemporary school of kokugaku, which emphasized the traditional understanding of Japan as entirely indigenous. Scholars of kokugaku often positioned their work as a polemic against what they perceived as the widespread influence of traditions imported from China, especially Confucianism, for their alleged corruption of an autochthonic Japanese culture. Modern interpreters of kokugaku thereby focused on the issue of their revulsion of Chinese influence. Focusing on Motoori Norinaga, often considered the consummator of kokugaku, this article analyzes Norinaga’s responses to interpretations of a possible Korean origin of Japanese culture and customs. By contriving commentaries that eliminated such possibilities, this article argues that Norinaga attempted to defend the traditional understanding of ancient Japan as entirely indigenous and unified ab initio.
Revealing the Miraculous: Objects Placed inside the Statue of the Kōfukuji Nan’endō Fukūkenjaku Kannon
Authors: Chan Yen-Yi
Published: November 2022

The use of relics and gorintō (five-element pagodas) as objects placed in Buddhist statues gained currency in the late twelfth century. This article examines the deposits (nōnyūhin) placed by Fujiwara no Kanezane (1149–1207) in 1189 within the statue of Fukūkenjaku Kannon in the Nan’endō at Kōfukuji in Nara, one of the earliest examples to contain both relics and gorintō. The article unravels the intricate relationship between the contents of the inserted objects, the meaning of the statue, and the motives behind the placing of the deposits. On the one hand, the deposits in this statue were carefully selected to manifest Kanezane’s conception of the sacred. On the other, they were intended to evoke a response from Fukūkenjaku Kannon to generate rebirth in Amida’s pure land. The relic deposit was enshrined because of its connection to Pure Land rebirth and was to transform the statue into a shōjinbutsu (living buddha) that assumed an array of meanings: an icon containing relics, a nexus for salvation, and a miraculous manifestation of the deity. It is also suggested that Pure Land belief was a driving force behind the increase in using relics as nōnyūhin in the late twelfth century.
The Construction of Medical Knowledge: A Semantic Taxonomy of Processes
Authors: Mocini Renzo
Published: November 2022

The semiotic reality of medical discourse is linguistically organised into figures arranged in the grammar of the clause. Each clause is comprised of entities and processes in various relationships to each other. The writers of medical texts represent and bestow meaning on their experience of the world by choosing from among a selection of different types of figures: of happening, sensing, doing, being, having, and saying. Processes play a central role in figures since they provide their own models for construing the experiential content and organising the information flow of medical texts. The rich architecture of Systemic Functional Linguistics can provide the theoretical background and analytical tools for a thorough investigation of the linguistic selections made by medical writers to convey clinical knowledge. Considering this key role, the present paper aims at investigating the most frequent verbs used as processes in a corpus of medical research articles. The study reveals that the most recurrent verbs used as processes in this type of textual configuration share semantic features. This makes it possible to propose a taxonomic approach to processes with a view to studying their grammatical configuration and the discourse functions they serve.
Polycystic ovary syndrome: pathogenetic mechanisms of the disease (part 1)
Authors:   Mutah University, Al-Jefout M.
Published: November 2022

The article presents analysis of modern literature data on risk factors and pathogenesis of polycystic ovary syndrome (PCOS). Despite numerous studies, it has not been possible so far to formulate a unified concept of the pathogenesis and etiology of PCOS. This lecture considers mechanisms of PCOS development. The role of impaired steroidogenesis in the adrenal glands and ovaries in PCOS is observed. The focus is assigned to insulin resistance that is likely involved in the development of reproductive PCOS phenotype and might mediate on some of the changes in ovarian morphology seen in this disease. It has been shown that not only hereditary factors lead to the development of this syndrome, but also lifestyle, physical activity and concomitant somatic diseases.
Oligonucleotide aptamers as novel cell-specific delivery agents for boron neutron capture therapy
Authors:   Institute of Chemical Biology and Fundamental Medicine SD RAS, Vorobyeva M.A. , Dymova M.A. ,   Institute of Chemical Biology and Fundamental Medicine SD RAS, Novopashina D.S. ,   Institute of Chemical Biology and Fundamental Medicine SD RAS, Kuligina E.V. ,   Institute of Chemical Biology and Fundamental Medicine SD RAS, Kolesnikov I.A. ,   Institute of Chemical Biology and Fundamental Medicine SD RAS, Taskaev S.Yu. ,   Institute of Chemical Biology and Fundamental Medicine SD RAS, Richter V.A. ,   Institute of Chemical Biology and Fundamental Medicine SD RAS, Meschaninova M.I. ,   Institute of Chemical Biology and Fundamental Medicine SD RAS
Published: November 2022

Oligonucleotide aptamers seem to be promising delivery vehicles addressing boron compounds to tumour cells for boron neutron capture therapy (BNCT). Here, we report the first example of using 2'-F-RNA aptamer specific to human glioblastoma cells as a delivery agent for boron clusters, which provides cell internalisation sufficient for the BNCT model.
Magnetomechanical regeneration of bone tissue using of superparamagnetic nanoparticles
Authors:   Prof. V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Zamay G.S. , Koshmanova A.A. ,   Prof. V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Khorzhevskii V. ,   Prof. V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Lubnin A.M. ,   Regional GovernmentOwned Publicly Funded Healthcare Institution "Regional Clinical Hospital", Babkin V.A. ,   LLC INPF "Chemistry of Wood", Medvedeva E.N. ,   LLC INPF "Chemistry of Wood", Zamay T.N. ,   Prof. V. F. Voino-Yasenetsky Krasnoyarsk State Medical University
Published: November 2022

Here we evaluated the ability of superparamagnetic ferroarabinogalactan nanoparticles functionalized with RGD peptide (an integrin receptor ligand) to accelerate the repair of a cranial vault defect under the influence of a low-frequency alternating magnetic field. A defect of the cranial vault was used as a model of a bone injury, which is usually used on rodents, since the structure of the cranial vault allows creating a standardized burr hole that can be analyzed using histological and radiographic analysis. Functionalization of ferroarabinogalactans with the RGD peptide was performed by incubation of ferroarabinogalactans with the peptide. The study of the effectiveness of magnetomechanical transduction in vivo was carried out on 8-week-old male ICR mice. Magnetomechanical stimulation of bone tissue caused regeneration in the group of animals treated with FeAG functionalized with the RGD peptide (the cranial defect was practically restored after 7 days). At the same time, in the groups of control animals, the restoration of the bone defect did not occur during this time. After 2 weeks of magnetomechanical therapy, cranial vault defects in the animals of the experimental group were completely restored. Mice in the control groups did not recover. Ferroarabinogalactans effectively restore bone defects in a low-frequency magnetic field.
The role of single nucleotide polymorphisms of pro-inflammatory factor genes as predictors of risk of development and severity of acute pancreatitis
Authors:   Prof. V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Dunaevskaya S.S. , Sergeeva E.Yu. ,   Prof. V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Deulina V.V. ,   Prof. V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Domoratskaya E.A. ,   Prof. V. F. Voino-Yasenetsky Krasnoyarsk State Medical University
Published: November 2022

A literature review has been conducted examining the role of single nucleotide polymorphisms of pro-inflammatory factor genes as predictors of risk of developing and severity of acute pancreatitis. The review was conducted on the following databases: Pub Med, Scopus for the period from 2009 to 2021 according to the following keywords: acute pancreatitis, hereditary pancreatitis, severe acute pancreatitis, gene polymorphism, single nucleotide genes, proinflammatory factors. A number of mutations and single nucleotide polymorphisms have been identified, which are the main triggers or cofactors of the initiation of both acute and chronic hereditary pancreatitis. The percentage of cases of idiopathic recurrent acute pancreatitis and idiopathic chronic pancreatitis associated with genetic mutations is 30-60% and 12-43%, respectively. The following genetic variants of the cationic trypsinogen (PRSS1) gene - CFTR, SPINK1 and chymotripsin C (CTRC) - are most often associated with the development of pancreatitis. Inherited pancreatitis associated with gene mutations has SPINK1 autosomal recessive inheritance pattern. When the mutant gene is expressed, the synthesis of a strong trypsin inhibitor prevents premature activation of immature trypsinogen. Data are obtained that IL-6, IL-8, FNOα can activate NF kB transcription factor, inducing, thus, increase in an expression 2 DRIED. It has been found that some COX 2 polymorphisms characterized by increased expression of this enzyme create prerequisites for the progression of the inflammation process, and are possibly predictors of the development of severe acute pancreatitis.
Quality of life of patients after surgical treatment of unruptured brain aneurysm: a literature review
Authors:   Moscow Regional Clinical Research Institute named after M.F. Vladimirsky, Dzhindzhikhadze R.S. , Polyakov A.V. ,   Moscow Regional Clinical Research Institute named after M.F. Vladimirsky, Zaitsev A.D. ,   Medical Academy of Postgraduate Education, Ermolaev A.Yu. ,   Moscow Regional Clinical Research Institute named after M.F. Vladimirsky, Odamanov D.A. ,   Clinical Hospital № 1 Medsi
Published: November 2022

The problem of high disability and mortality after aneurysmal hemorrhages has led to the fact that preventive exclusion of unruptured aneurysms has been the standard of care for many years. Indications for complex operative intervention are equated to the possibility of functional independence loss. The relevance of this study is due to the lack of data on the quality of life of patients after surgical treatment of unruptured cerebral aneurysms in Russian literature. Using the PubMed, Web of Science, Google Scholar databases and the terms “quality of life and unruptured intracranial aneurysm”, articles from 1998 to 2019 were analysed. Patients’ awareness of the presence of cerebral aneurysms often impairs the quality of life, causes anxiety and depression, limits their work and daily activities, and leads them to the choice of surgical intervention. Cultural-linguistic adaptation and validation of scales and questionnaires on the quality of life after the treatment of unruptured brain aneurysms is a necessary measure for domestic research. This article outlines the modern ideas about the epidemiology and natural course of the disease, approaches to treatment of unruptured cerebral aneurysms. Particular attention is devoted to the quality of life of patients after surgery.
Palliative surgical treatment of malignant tumours in the pancreatobiliary area complicated by obstructive jaundice using local and systemic photodynamic therapy
Authors:   Altai State Medical University, Tseimakh A.E. , Lazarev A.F. ,   Altai State Medical University, Sekerzhinskaya E.L. ,   Russian Oncological Research Center named after N.N. Blokhin, Kurtukov V.A. ,   City Hospital No. 5, Barnaul, Mishchenko A.N. ,   City Hospital No. 5, Barnaul, Tepluhin V.N. ,   City Hospital No. 5, Barnaul, Korenovskiy Yu.V. ,   Altai State Medical University, Suzopov E.V. ,   Altai State Medical University, Zharikova G.V. ,   Altai State Medical University, Shoikhet Ya.N. ,   Altai State Medical University
Published: November 2022

The paper analyses the tactics of managing patients with malignant neoplasms in the pancreatobiliary area complicated by obstructive jaundice in two nosologically and clinically comparable groups of patients. The aim of the research. To evaluate the effectiveness of complex palliative treatment with the use of photodynamic therapy in patients with malignant neoplasms in the pancreatobiliary area complicated by obstructive jaundice. Material and methods. In the main group, which consisted of 41 patients, palliative complex treatment was carried out using local and systemic photodynamic therapy of neoplasms in the pancreatobiliary area complicated by obstructive jaundice, purulent cholangitis. In the comparison group, which consisted of 165 patients, palliative complex treatment of complications was carried out without the use of photodynamic therapy. Complex palliative treatment in both groups included the following surgical interventions: percutaneous transhepatic mono- and bilobar drainage of the bile ducts, stenting of the bile ducts under ultrasound and X-ray control as well as bypass biliodigestive anastomoses. Symptomatic conservative treatment included infusion, detoxification, analgesic, hepatoprotective and antibacterial therapy. Results. Against the background of local and systemic photodynamic therapy in the main group, a decrease in the largest size of the neoplasm in patients with malignant neoplasms of the pancreas from 42.5 mm to 38 mm within a week after treatment was established according to the data of multispiral computed tomography of abdominal organs with intravenous bolus contrast. The largest neoplasm size decreased from 40.5 mm to 31 mm within a month after treatment according to the ultrasound examination of the abdominal cavities. Restoration of bile excretion into the intestine in 100% of patients with malignant neoplasms of the bile ducts and the head of the pancreas was registered, as well as an increase in life expectancy of patients by more than 1 year, a decrease in the risk of complications due to a slowdown in the growth of neoplasms associated with a decrease in the concentration of the cytokine TNF-α. Conclusion. Complex treatment with the use of photodynamic therapy of malignant neoplasms of the pancreatobiliary area allows reducing the largest size and rate of neoplasm invasion and to increase the survival rate of patients.
Chronic endometritis: current problems of diagnosis
Authors:   Kant Baltic Federal University, Goncharova E.A. , Volkova L.V. ,   Kant Baltic Federal University, Pashov A.I. ,   Kant Baltic Federal University, Rachkovskaya V.V. ,   Kant Baltic Federal University
Published: November 2022

The review deals with the relevant problems of chronic endometritis diagnostics, which is the cause of infertility, unsuccessful attempts of in-vitro fertilisation and miscarriage. The frequency of this pathology varies within 2.8-56.8% in women with infertility and 9.3-67.6% in patients with recurrent miscarriages and amounts to 57.8% in missed pregnancies in medical history. The analysis of modern publications predominantly from E-library and PubMed databases for the period 2012-2021 was carried out. The key points of etiopathogenesis, diagnostic methods, their possibilities and limitations were analysed. The issues of the “gold standard” and new biomarkers for morphological verification of chronic endometritis were considered. An analysis of the literature has shown that, despite complex diagnostic approaches, many aspects of the pathogenesis of this pathology are not completely clear, and pathoanatomical diagnostic standards do not fully meet modern requirements.
A new method for predicting the nature of changes in the gallbladder wall in acute cholecystitis
Authors:   Chita State Medical Academy, Yashnov A.A. , Lobanov S.L. ,   Chita State Medical Academy, Konovalova O.G. ,   Chita State Medical Academy, Burtseva M.A. ,   Chita State Medical Academy
Published: November 2022

The aim of the research. To develop a method for predicting the degree of changes in the gallbladder wall in acute cholecystitis. Material and methods. A single-stage study was performed on 105 patients with an established diagnosis of acute cholecystitis who underwent laparoscopic cholecystectomy, comparable in age, gender and concomitant pathology. Upon admission to the hospital, the activity of creatine phosphokinase (CPK), lactate dehydrogenase (LDH), gamma-glutamiltranspeptidase (GGTP) and alkaline phosphatase was determined through the kinetic colorimetric method. Statistical processing of the obtained results was carried out using the SPSS Statistics 7.0 program in compliance with the principles of statistical analysis adopted for research in biology and medicine. Results. In patients with acute destructive cholecystitis, mean CPK values were 302.2±32.5 U/l (p <0.05) and LDH - 318.3±29.4 U/l (p <0.05), which is higher than the values obtained in the group with acute non-destructive cholecystitis: CPK – 168.7±18.3 U/l (p <0.05) and LDH – 282.6±18.3 U/l (p <0.05). Along with this, a direct correlation was revealed between an increase in the concentration of CPK, LDH and the degree of destructive process in the gallbladder wall. At the same time, in patients with non-destructive cholecystitis, mean values were 340±116.9 U/l (p <0.05) for GGTP and 160.3±34.2 U/l (p <0.05) for SCHF, which exceeds these values in the group of patients with acute destructive cholecystitis: GGTP was 70.5±18.5 U/l (p <0.05), and SCHF was 93.5±16.5 U/l (p <0.05). With progression of destructive processes in the gallbladder wall, the concentration of GGTP and alkaline phosphatase decreases.
Indicators of oxytocin level in blood serum of newborns taking into account the type of feeding
Authors:   The Center of Maternal and child health, Ovchinnikova T.V. , Lopatina O.L. ,   Prof. V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Taranushenko T.E. ,   Prof. V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Salmina A.B. ,   Prof. V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Salmin V.V. ,   Prof. V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Karpova L.S. ,   Prof. V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Golubenko N.K. ,   Regional Clinical Center for Maternal and Child Health
Published: November 2022

The aim of the research. To analyse the level of oxytocin in the blood serum of premature and full-term newborns in various types of feeding (according to the Department of Pathology of Newborns and Premature Infants of the Krasnoyarsk Regional Clinical Center for Maternal and Child Health). Material and methods. A single-centre open-label prospective study including 24 preterm infants (at 26 to 36 weeks of gestation) and 14 full-term newborns was carried out. The levels of oxytocin in the blood serum of the examined children on various types of feeding (breastfeeding and artificial) were analysed in dynamics on days 5-6 and 11-12. Results. It has been established that among full-term children, the average values of oxytocin did not have significant differences between the subgroups of breastfeeding and artificial feeding and significantly exceeded the levels of oxytocin in premature infants. The most likely reason for the low level of OT should be considered the higher vulnerability to multiple external influences (examinations and manipulations, temperature, humidity, incubator conditions, care specifics, etc.) that accompany newborns with a small gestational age. Suppression of OT secretion at the stage of the general adaptation syndrome may be due to a pronounced activation of the sympathetic-adrenal system in premature infants in response to the stress situation with an increase in the level of adrenaline and norepinephrine. Analysis of the level of OT in premature infants in various types of feeding depending on body weight at birth in BF and AF showed an inverse relationship between the level of the studied hormone and body weight at birth (the lower the birth weight, the higher the level of OT on the 5th-6th day of postnatal life). Conclusion. In modern literature, data on the physiological effects of oxytocin and the participation of the hormone in the course of a number of pathologies are being actively updated. New findings from recent studies point to the role of oxytocin not only in labour but also in multiple effects on the fetus and newborns. Maternal oxytocin can reach fetal neurons across both the placental and blood-brain barriers. At the same time, the physiological significance of the influence of oxytocin on the brain and the dependence on the type of feeding in newborns are insufficiently studied and are a subject of discussion, but mainly in experimental studies
The frequency of cardiac arrhythmias in children according to Holter ECG monitoring
Authors:   Irkutsk State Medical Academy of Continuing Education, Tolstikova T.V. , Marchuk T.P. ,   Irkutsk State Regional Children’ s Clinical Hospital
Published: November 2022

The aim of the research. To study the frequency and structure of cardiac arrhythmias in children. Material and methods. Analysis of the results of 24-hour Holter ECG monitoring of 255 children who underwent outpatient and inpatient examinations at the Irkutsk State Regional Children’s Clinical Hospital was carried out. The age of the patients ranged from 2 months to 18 years. For SCM-ECG, the following devices were used: Holter-DMS (Russia), Card(X)plore (Hungary), Schiller MT-200 (Switzerland). Results. The most common rhythm disturbances were supraventricular pacemaker migration (96%), 2nd degree sinoatrial blockade (86%), a combination of supraventricular pacemaker migration, SA blockade and single supraventricular extrasystoles (21%). These arrhythmias belong to the first variant of the syndrome of weakness of the sinus node associated with disorders of the autonomic nervous system. The second variant of the syndrome of weakness of the sinus node was detected in 39.2%, the third variant was not detected in any child and variant 4 was found in 26.3% of the cases. Ectopic activity in the form of supraventricular extrasystole was detected in 66%, ventricular extrasystole – in 15% of the children. Paroxysmal supraventricular tachycardia was registered in 6% of cases, ventricular paroxysmal tachycardia – in 1.2% of the children. Atrioventricular blockade of the 1st degree was detected in 16%, 2nd degree of the 1st type – in 7.5%, 2nd degree of the 2nd type – in 3.1%, 3rd degree – in 0.8% of the examined children. The WPW syndrome occurred in 3.5% of the cases, long QT syndrome – in 1.6%, atrial fibrillation and flutter – in 0.8% of the cases. Thus, life-threatening arrhythmias were detected in 49 children (19%). Conclusion. A variety of forms of rhythm and conduction disturbances, which are often life-threatening and can lead to sudden cardiac death, is characteristic for both children and adults.
Rare clinical cases of ectopic pregnancies terminated in the second trimester of gestation
Authors:   Simferopol Clinical Maternity Hospital № 1, Sulima A.N. , Rumyantseva Z.S. ,   Medical Academy named after S. I. Georgievsky, Kucherenko Yu.A. ,   Medical Academy named after S. I. Georgievsky, Rybalka A.N. ,   Medical Academy named after S. I. Georgievsky, Baskakov P.N. ,   Medical Academy named after S. I. Georgievsky, Beglitse D.A. ,   Medical Academy named after S. I. Georgievsky, Gordeychik A.E. ,   Republican Clinical Hospital named after N. A. Semashko, Adamov A.M. ,   Medical Academy named after S. I. Georgievsky, Stryukova O.V. ,   Medical Academy named after S. I. Georgievsky
Published: November 2022

In Russia in 2017, according to the Rosstat data, ectopic pregnancy in the structure of maternal mortality was 8.10%, and in 2018 it decreased by 2 times, amounting to 4.18%. The frequency of rare forms of ectopic pregnancy reaches 5-8.3%, and the course is characterised by massive bleeding, often with a fatal outcome. The article describes rare cases of ectopic pregnancy that have occurred in our clinical practice and were interrupted at the terms of 13 and 15-16 weeks with a favourable outcome, which will be interesting not only for practicing obstetricians and gynaecologists, but also doctors of other specialties. The difficulties in the diagnosis, as well as the tactics of management and surgical treatment of these patients are described.
Plataformas digitais proprietárias na educação pública
Authors: Barrera Débora Furtado , Moraes Raquel de Almeida
Published: November 2022

Este artigo tem como objetivo investigar a adesão de cinco universidades federais do Centro-Oeste aos serviços de educação das grandes corporações da informática, a saber: Microsoft e Google a partir da seguinte indagação: no contexto do ensino remoto emergencial, as universidades federais do Centro-Oeste adotam ou sugerem à comunidade acadêmica os serviços de plataformas proprietárias para o desenvolvimento de suas atividades acadêmicas? A metodologia empregada envolve pesquisa bibliográfica, por meio da análise de artigos acadêmicos e documentos institucionais. Dentre os resultados, destaca-se que, à exceção da Universidade Federal de Mato Grosso (UFMT), todas as outras quatro universidades federais do Centro-Oeste analisadas propuseram documentos e formações para o uso de plataformas do Google e da Microsoft. Amparados pelos estudos teóricos de Van Djick e Poell (2018) e Parra et al. (2018), observa-se que essas são organizações privadas internacionais com acesso aos dados de pesquisa, desenvolvimento e inovação das universidades públicas brasileiras. Como conclusão, a pesquisa formula a seguinte hipótese: à medida que as universidades aderem a parcerias gratuitas ou “muito vantajosas” oferecidas pelas grandes corporações para a realização de suas atividades acadêmicas, perde-se a oportunidade de desenvolver tecnologias públicas de informação e comunicação voltadas ao desenvolvimento do país.
Postoperative infection after cranioplasty in traumatic brain injury: a single center experience
Authors: Ha Mahnjeong , Lee Jung Hwan , Choi Hyuk Jin , Kim Byung Chul , Yu Seunghan
Published: November 2022

Purpose: To determine the incidence and risk factors of postoperative infection after cranioplasty in patients with traumatic brain injury (TBI).Methods: Data of 289 adult patients who underwent cranioplasty after TBI at a single regional trauma center between year 2018 and 2021 were reviewed retrospectively. Patient characteristics and various procedural variables, such as interval between craniectomy and cranioplasty, estimated blood loss, laterality and materials of the bone flap, and duration and classification of perioperative antibiotics usage were analyzed.Results: Postoperative infection occurred in 17 patients (5.9%). Onset time of infectious symptom ranged from 9 days to 174 days (median, 24 days) after cranioplasty. The most common cultured organism was Staphylococcus aureus (47.1%), followed by Klebsiella pneumoniae (17.6%) and Enterococcus faecalis (17.6%). Patients with postoperative infection were more likely to have diabetes (odds ratio [OR], 6.96; 95% confidence interval [CI], 1.92–25.21; P=0.003), lower body mass index (OR, 0.81; 95% CI, 0.66–0.98; P=0.029), and shorter duration of perioperative antibiotics (OR, 0.83; 95% CI, 0.71–0.98; P=0.026).Conclusions: For TBI patients with diabetes, poor nutritional status should be managed cautiously for increased risk of infection after cranioplasty. Further studies and discussions are needed to determine an appropriate antibiotics protocol in cranioplasty.
Home dialect: A deficit towards enhanced additional language learning
Authors: Makena Bulelwa , Matiso Nomasomi Hilda
Published: November 2022

This paper aims to investigate whether home language teaching has an impact on enhanced additional language learning pedagogies. Participants, as data sources, were four university teachers purposely identified because of the task assigned to them, assessing student teachers in diverse schools during TP. Data for this inquiry was collected through semi-structured interviews. It was divulged as the main findings that (i) time constraints caused by consistent code-switching to acquaint with the unfamiliar medium, and (ii) learner dropout rate were challenges. This paper concludes that policies need to be redefined for enhanced language proficiency so that the ultimate end is learners who can communicate globally in a wide range of linguistic constituencies.