bluuebunny/crossref_metadata_2025 huggingface dataset:
Remanufacturing Closed-Loop Supply Chain Contract Coordination Considering Quality Control
Authors: Duan Wei , Liu Mingli , Xu Desheng , Han Liping
Published: September 2024

The quality control of remanufactured products in a closed-loop supply chain (CLSC) can significantly influence consumers’ decision-making, and the contract coordination of CLSC has also become a research hotspot. This paper explores the quality control problem in a three-level remanufacturing CLSC consisting of a remanufacturer, a retailer, and a recycler by constructing a system dynamics (SD) model, which contains two contract schemes: quality control contract and quality control–revenue-sharing contract. Subsequently, the proposed SD model is analyzed using various schemes. The findings suggest that without mandatory contracts, CLSC members are frequently unable to fulfill their quality improvement commitments. Among them, recyclers are less likely to improve quality and more prone to breaking promises. The quality control problem in CLSC can be addressed through contract coordination, and the quality control contract scheme can avoid non-compliance with quality improvement commitments. The application of the quality control–revenue-sharing combination contract scheme not only resolves the quality control issue but also promotes profit improvement in the CLSC.
MAMGD: Gradient-Based Optimization Method Using Exponential Decay
Authors: Sakovich Nikita , Aksenov Dmitry , Pleshakova Ekaterina , Gataullin Sergey
Published: September 2024

Optimization methods, namely, gradient optimization methods, are a key part of neural network training. In this paper, we propose a new gradient optimization method using exponential decay and the adaptive learning rate using a discrete second-order derivative of gradients. The MAMGD optimizer uses an adaptive learning step, exponential smoothing and gradient accumulation, parameter correction, and some discrete analogies from classical mechanics. The experiments included minimization of multivariate real functions, function approximation using multilayer neural networks, and training neural networks on popular classification and regression datasets. The experimental results of the new optimization technology showed a high convergence speed, stability to fluctuations, and an accumulation of gradient accumulators. The research methodology is based on the quantitative performance analysis of the algorithm by conducting computational experiments on various optimization problems and comparing it with existing methods.
PARKTag: An AI–Blockchain Integrated Solution for an Efficient, Trusted, and Scalable Parking Management System
Authors: Kalbhor Atharva , Nair Rashmi S. , Phansalkar Shraddha , Sonkamble Rahul , Sharma Abhishek , Mohan Harshit , Wong Chin Hong , Lim Wei Hong
Published: September 2024

The imbalance between parking availability and demand has led to a rise in traffic challenges in many cities. The adoption of technologies like the Internet of Things and deep learning algorithms has been extensively explored to build automated smart parking systems in urban environments. Non-human-mediated, scalable smart parking systems that are built on decentralized blockchain systems will further enhance transparency and trust in this domain. The presented work, PARKTag, is an integration of a blockchain-based system and computer vision models to detect on-field free parking slots, efficiently navigate vehicles to those slots, and automate the computation of parking fees. This innovative approach aims to enhance the efficiency, scalability, and convenience of parking management by leveraging and integrating advanced technologies for real-time slot detection, navigation, and secure, transparent fee calculation with blockchain smart contracts. PARKTag was evaluated through implementation and emulation in selected areas of the MIT Art Design Technology University campus, with a customized built-in dataset of over 2000 images collected on-field in different conditions. The fine-tuned parking slot detection model leverages pre-trained algorithms and achieves significant performance metrics with a validation accuracy of 92.9% in free slot detection. With the Solidity smart contract deployed on the Ethereum test network, PARKTag achieved a significant throughput of 10 user requests per second in peak traffic hours. PARKTag is implemented as a mobile application and deployed in the mobile application store. Its beta version has undergone user validation for feedback and acceptance, marking a significant step toward the development of the final product.
Comparison of Different HIV-1 Resistance Interpretation Tools for Next-Generation Sequencing in Italy
Authors: Armenia Daniele , Carioti Luca , Micheli Valeria , Bon Isabella , Allice Tiziano , Bonura Celestino , Bruzzone Bianca , Bracchitta Fiorenza , Cerutti Francesco , Giammanco Giovanni Maurizio , Stefanelli Federica , Bonifacio Maria Addolorata , Bertoli Ada , Vatteroni Marialinda , Ibba Gabriele , Novazzi Federica , Lipsi Maria Rosaria , Cuomo Nunzia , Vicenti Ilaria , Ceccherini-Silberstein Francesca , Rossetti Barbara , Bezenchek Antonia , Saladini Francesco , Zazzi Maurizio , Santoro Maria Mercedes
Published: September 2024

Background: Next-generation sequencing (NGS) is gradually replacing Sanger sequencing for HIV genotypic drug resistance testing (GRT). This work evaluated the concordance among different NGS-GRT interpretation tools in a real-life setting. Methods: Routine NGS-GRT data were generated from viral RNA at 11 Italian laboratories with the AD4SEQ HIV-1 Solution v2 commercial kit. NGS results were interpreted by the SmartVir system provided by the kit and by two online tools (HyDRA Web and Stanford HIVdb). NGS-GRT was considered valid when the coverage was >100 reads (100×) at each PR/RT/IN resistance-associated position listed in the HIVdb 9.5.1 algorithm. Results: Among 629 NGS-GRT, 75.2%, 74.2%, and 70.9% were valid according to SmartVir, HyDRA Web, and HIVdb. Considering at least two interpretation tools, 463 (73.6%) NGS-GRT had a valid coverage for resistance analyses. The proportion of valid samples was affected by viremia <10,000–1000 copies/mL and non-B subtypes. Mutations at an NGS frequency >10% showed fair concordance among different interpretation tools. Conclusion: This Italian survey on NGS resistance testing suggests that viremia levels and HIV subtype affect NGS-GRT coverage. Within the current routine method for NGS-GRT, only mutations with frequency >10% seem reliably detected across different interpretation tools.
Molecular Design of Encapsulin Protein Nanoparticles to Display Rotavirus Antigens for Enhancing Immunogenicity
Authors: Jung Hyun-Gyo , Jeong Seonghun , Kang Min-Ji , Hong Ingi , Park Young-Shin , Ko Eunbyeol , Kim Jae-Ouk , Choi Deog-Young
Published: September 2024

Rotavirus considerably threatens global health, particularly for children <5 years. Current, licensed oral attenuated vaccine formulations have limitations including insufficient efficacy in children in low- and middle-income countries, warranting urgent development of novel vaccines with improved efficacy and safety profiles. Herein, we present a novel approach utilizing an encapsulin (ENC) nanoparticle (NP)-based non-replicating rotavirus vaccine. ENC, originating from bacteria, offers a self-assembling scaffold that displays rotavirus VP8* antigens on its surface. To enhance the correct folding and soluble expression of monomeric antigens and their subsequent assembly into NP, we adopted an RNA-interacting domain (RID) of mammalian transfer RNA synthetase as an expression tag fused to the N-terminus of the ENC-VP8* fusion protein. Using the RID-ENC-VP8* tripartite modular design, insertion of linkers of appropriate length and sequence and the universal T cell epitope P2 remarkably improved the production yield and immunogenicity. Cleavage of the RID rendered a homogenous assembly of ENC-P2-VP8* into protein NPs. Immunization with ENC-P2-VP8* induced markedly higher levels of VP8*-specific antibodies and virus neutralization titers in mice than those induced by P2-VP8* without ENC. Altogether, these results highlight the potential of the designed ENC NP-based rotavirus vaccine as an effective strategy against rotavirus disease to address global health challenges.
Immunity to Varicella Zoster Virus in Healthcare Workers: A Systematic Review and Meta-Analysis (2024)
Authors: Riccò Matteo , Ferraro Pietro , Zaffina Salvatore , Camisa Vincenzo , Marchesi Federico , Franzoso Francesca Fortin , Ligori Cosimo , Fiacchini Daniel , Magnavita Nicola , Tafuri Silvio
Published: September 2024

Healthcare workers (HCWs) are occupationally exposed to varicella zoster virus (VZV), and their inappropriate vaccination status could contribute to an outbreak involving both professionals and the patients they care for, with a potential impact on the general population. Therefore, since 2007, the Advisory Committee on Immunization Practices (ACIP) recommends that all HCWs have evidence of immunity against varicella. The present meta-analysis was therefore designed to collect the available evidence on the seronegative status of VZV among HCWs. PubMed, Scopus, and Embase databases were searched without backward limit for articles reporting on the seroprevalence of VZV among HCWs, and all articles meeting the inclusion criteria were included in a random-effect meta-analysis model. From 1744 initial entries, a total of 58 articles were included in the quantitative analysis (publication range: 1988 to 2024), for a pooled sample of 71,720 HCWs. Moreover, the included studies reported on seroprevalence data on measles (N = 36,043 HCWs) and rubella (N = 22,086 HCWs). Eventually, the pooled seronegative status for VZV was estimated to be 5.72% (95% confidence interval [95% CI] 4.59 to 7.10) compared to 6.91% (95% CI 4.79 to 9.87) for measles and 7.21% (5.36 to 9.64) for rubella, with a greater risk among subjects younger than 30 years at the time of the survey (risk ratio [RR] 1.434, 95% CI 1.172 to 1.756). Interestingly, medical history of either VZV infection/vaccination had low diagnostic performances (sensitivity 76.00%; specificity 60.12%; PPV of 96.12% but PNV of 18.64%). In summary, the available data suggest that newly hired HCWs are increasingly affected by low immunization rates for VZV but also for measles and rubella, stressing the importance of systematically testing test newly hired workers for all components of the measles–pertussis–rubella–varicella vaccine.
Intranasal Immunization with a Recombinant Adenovirus Encoding Multi-Stage Antigens of Mycobacterium tuberculosis Preferentially Elicited CD8+ T Cell Immunity and Conferred a Superior Protection in the Lungs of Mice than Bacillus Calmette–Guerin
Authors: Wang Limei , Kang Jian , Jiang Hong
Published: September 2024

The development of a tuberculosis (TB) vaccine is imperative. Employing multi-stage Mycobacterium tuberculosis (Mtb) antigens as targeted antigens represents a critical strategy in establishing an effective novel TB vaccine. In this investigation, we evaluated the immunogenicity and protective efficacy of a recombinant adenovirus vaccine expressing two fusion proteins, Ag85B-ESAT6 (AE) and Rv2031c-Rv2626c (R2), derived from multi-stage antigens of Mtb via intranasal administration in mice. Intranasal delivery of Ad-AE-R2 induced both long-lasting mucosal and systemic immunities, with a preferential elicitation of CD8+ T cell immunity demonstrated by the accumulation and retention of CD8+ T cells in BALF, lung, and spleen, as well as the generation of CD8+ TRM cells in BALF and lung tissues. Compared to subcutaneous immunization with Bacillus Calmette-Guerin (BCG), Ad-AE-R2 provided superior protection against high-dose intratracheal BCG challenge, specifically within the lungs of mice. Our findings support the notion that empowering T cells within the respiratory mucosa is crucial for TB vaccine development while highlighting targeting CD8+ T cell immunity as an effective strategy for optimizing TB vaccines and emphasizing that eliciting systemic memory immunity is also vital for the successful development of a TB mucosal vaccine. Furthermore, our results demonstrate that the BCG challenge serves as a convenient and efficient method to evaluate candidate vaccine efficacy.
Формирование императива клинического маркетинга в управлении устойчивым развитием инноваций в медицинской промышленности
Authors:   Финансовый университет при Правительстве Российской Федерации, Зуенкова Юлия ,   Российский государственный гуманитарный университет
Published: September 2024

Рассматривается концепция клинического маркетинга как один из видов маркетинга в здравоохранении. Определен императив клинического маркетинга. К предпосылкам развития клинического маркетинга относят — переход на принципы доказательной медицины, ужесточение регулирование, увеличение стоимости создания инновационных медицинских продуктов. Выделены ключевые факторы успеха медизделия, которые ускоряют проникновение на рынок медицинских инноваций. Описана программа и основные инструменты клинического маркетинга, область их применения. Определена область приложения клинического маркетинга в соответствии с классом медицинских изделий. Показано, что применение элементов клинического маркетинга может положительно влиять на коммерциализацию инноваций в условиях политики импортозамещения медицинской промышленности.
BAHASA DAN KEKUASAAN: ANALISIS KRITIS TERHADAP DOMINASI BAHASA DALAM MASYARAKAT
Authors: - Kamaruzzaman , - Iche
Published: September 2024

It critically analyzes the relationship between language and power in the context of language dominance in society. This research explores how language becomes an important tool to reinforce power structures, regulate power relations between individuals and groups, and influence the construction of social identities. Using a critical approach, this research outlines how the selective use of language by dominant groups can suppress and marginalize minority groups, causing inequality in access to resources and opportunities. Historical, political, and social factors in the formation of power structures through language are also analyzed in depth. In addition, the abstract considers the ethical and political implications of language dominance in society, as well as efforts to break this dominance through multilingual advocacy, recognition of linguistic diversity, and promotion of linguistic equality. This research provides a deep insight into how language is not only a tool of communication but also a tool of power that significantly impacts the formation of inclusive or exclusive social structures.
FAKTA CERITA DALAM NOVEL "LEBIH SENYAP DARI BISIKAN" KARYA ANDINA DWIFATMA: STRUKTUR ROBERT STANTON
Authors: Siringoringo Yuni Novalina , Nasution Ikhwanuddin , Lubis Haris Sutan
Published: September 2024

ABSTRACK - The results of this research aim to describe the facts of the story in the novel More Senyap dari Bisikan by Andina Dwifatma. This research includes library research, while the method used is qualitative descriptive analysis. The data sources used are words, sentences, discourse in the novel More Senyap Than Bisikan by Andina Dwifatma. The approach used is Robert Stanton's structural approach. The results of this research are as follows, the story facts consist of the plot, characters and setting featured in the novel. The plot used in the novel Silent Than a Whisper is a forward plot. The characters in the novel are obsessive, worried and over thinker, hardworking, The setting in the story is still in the same city, the setting used is: Amara and Baron's house, the time setting used is: morning, afternoon, afternoon and evening. The social setting in the novel is: beliefs, ways of thinking, living habits, traditions.
Key words: Robert Stanton structure, story facts, novel
KONFLIK BATIN TOKOH UTAMA DALAM NOVEL KIARA KARYA DINNI ADHIAWATY: KAJIAN PSIKOLOGI SASTRA
Authors: Alfi Mairanda , Nasution Ikhwanuddin , Harahap Nurhayati
Published: September 2024

This research focuses on the Inner Conflict of the Main Character in Kiara's Novel by Dinni Adhiawaty: A Literary Psychology Study. This study aims to describe the forms of inner conflict in the novel Kiara by Dinni Adhiawaty using literary psychology studies. The theory used in this research is Kurt Lewin's theory. The research method used in this research is descriptive-qualitative. The data source used in this research is the novel Kiara by Dinni Adhiawaty, in the form of words and sentences. The results of this study are three forms of inner conflict according to Kurt Lewin's theory: approach-approach conflict, avoidance-avoidance conflict, and approach-avoidance conflict.
Penggunaan Recurrent Neural Network Dalam Mendeteksi Sentimen Berbahaya Pada Platform Media Sosial
Authors: Chuanta Roy Vidia , Harahap Mawaddah , Putra Adya Zizwan
Published: September 2024

Social media platforms in today's modern era make it easier for people to communicate and socialize. Behind that, on a hot topic, there must be sentiment. Every sentiment the community conveys varies; some are good and neutral, and some are bad or dangerous. To detect sentiment, start from crawling data, pre-processing, labeling, and then testing or training to get accuracy value, recall value, f1 value, and precision value using Long Short Term Memory. They obtained an accuracy value of 0.582, recall value of 0.582, f1 value of 0.428, and precision of 0.339. This LSTM model can be used to develop an analysis model that is successfully achieved.
SISTEM INFORMASI PELAYANAN PUBLIK DESA SATU PINTU BERBASIS WEB
Authors: Mutiara Linda , - Yuliadi , Mulyanto Yudi , - Rodianto , Ikram Fadhli Dzil , Ismiyarti Wilia , Rosika Herliana
Published: September 2024

The Web-Based One-Stop Village Public Service Information System (Case Study: Senawang Village Office, Orong Telu District) was completed using Visual Studio Code, Codeigniter programming language, and MySQL database. The research method used is qualitative, and the software development method, Prototype method, and system design method use four Unified Modeling Language (UML) diagrams consisting of use case diagrams, activity diagrams, sequence diagrams, and class diagrams. It has passed the testing process using Black Box. It has successfully provided information to users (Community) regarding services, namely birth report data, death reports, registration of migrants, applications for moving residents, and applications for certificates of incapacity. It can make complaints on the website link of the Senawang Village Office, Orong Telu District, Sumbawa Regency, West Nusa Tenggara.
PERAN STRES KERJA POSITIF (EUSTRESS) TERHADAP STRES KERJA PADA KARYAWAN
Authors: Shafira Nadia , Nasution Fenty Zahara
Published: September 2024

Stress at work is something that often happens to employees. Most people are their own worst enemy when it comes to stress. They throw themselves into long hour, high stress jobs while simultaneously adding even more stress outside of work by needlessly stacking commitments and responsibilities that trap even more. This stress could have implications well if stresssors stimulate the levels that can be compensated, this is called eustress. Otherwise, if it is excessive, it can cause distress, then the role of eustress can help employees in dealing with work stress problems. This study aims to describe the role of eustress. The method used is a quaitaive method with a literature study method related to the role of work stress
Overcoming Sleep Problems in Senior College Students with Hypnotherapy: A Trial
Authors: Dinata Umi Nur Kholifah , Dinata Konto Iskandar
Published: September 2024

This study aims to determine the effectiveness of hypnotherapy in reducing insomnia scores in final year students. This study uses a quasi-experimental single design method and one group pretest experimental design, posttest design, namely the research design used to influence an effect (intervention) in a single case. The methods that used data collection are in the form of observation, unstructured interviews, and measurements through the Pittsburgh Rating Insomnia Scale. The collection of assessment data refers to the author. These results indicate that there is a difference in the level of insomnia between before and after a visual hypnotherapy intervention. From the existing insomnia rate scores, the results show a decrease in the pre, post, and follow-up scores on the insomnia rates seen by the subjects.
PENGARUH EFIKASI DIRI TERHADAP PROKRASTINASI AKADEMIK PADA SISWA KELAS XI SMAN 1 TELUKJAMBE BARAT
Authors: Septiyan Dwi , Simatupang Marhisar , Sadijah Nur Ainy
Published: September 2024

A school is a place where people learn. Students receive many assignments, especially those related to their subject. Educators give assignments to students to teach them to take advantage of their free time in understanding and are obliged to arrange the work given. However, in practice there are still problems related to the assignments given by the teacher. One of them is academic procrastination. Academic procrastination has several factors, one of which is low student self-efficacy. Therefore, this study aimed to determine the effect of self-efficacy on academic procrastination in class XI students of SMAN 1 Telukjambe Barat. This research uses quantitative methods. In this study, data collection used the self-efficacy scale which refers to Bandura's theory while academic procrastination refers to Ferrari's theory. This research involved 132 students as the research sample, selected from the total student population of 196 students using purposive sampling. The results of the simple linear regression analysis obtained sig. namely 0.000 <0.05 (p <0.05) which means that there is an effect of self-efficacy on academic procrastination seen from the value of count has a value of -5.132 meaning that if student self-efficacy is low then academic procrastination in these students will be high, besides that based on the results The calculation of the coefficient of determination shows that the magnitude of the influence of the self-efficacy variable on academic procrastination is 16.4%. In comparison, other variables influence the remaining 83.6%.
Sulit Mengungkapkan Emosi: Kecerdasan Emosi Dan Attachment Style Dengan Alexithymia Pada Generasi Z
Authors: - Marisalia , Reza Faisal Adnan , Fitriani Annisa
Published: September 2024

Generation Z is a generation that is prone to mental health problems caused by poor social relationships and emotions. One of the mental health problems experienced by Generation Z is alexithymia. This happens because not all individuals can identify, describe, and express their emotions. Therefore, this study was conducted to determine the relationship between emotional intelligence and attachment style with alexithymia in Generation Z. The method used in this research is a quantitative approach method, with research sampling using a purposive sampling technique. The sample used in this study is Generation Z, with a vulnerable age of 15-19 years, who are in high school (SMA), and as many as 100 respondents. Then, the researcher used multiple linear regression test techniques to analyze the data. The results obtained from this study indicate that the variables of emotional intelligence and attachment style have a negative-significant effect on the alexithymia variable with an R-value of 0.697, R-square of 0.485 with an F value of 45.736 and a P-value of <0.001 (p<0.001). The higher the emotional intelligence and attachment style, the lower the alexithymia and vice versa.
Pengaruh Efikasi Diri Terhadap Kesiapan Pembelajaran Mandiri Mahasiswa Di Jawa Tengah
Authors: Robaiyani Siti , Nurhaliza Karyati , Aini Dewi Khurun
Published: September 2024

Independent learning readiness is needed for students due to student-focused learning. However, some students need higher self-learning readiness. This is certainly an obstacle for students when participating in learning activities. The purpose of this study is to empirically examine the effect of self-efficacy on the readiness of students in central java to learn independently. This research is quantitative with an inferential approach. This study used a quantitative approach involving 101 students from central java. The research scale used is independent learning readiness and self-efficacy scales. The data obtained were then analyzed using simple linear regression techniques. The statistical results analyzed using spss showed a significance value of 0.000 <0.05. From these results, self-efficacy has a positive and significant effect on students' readiness for independent learning in central java.
Hipertensão na gravidez como precedente para doenças cardiovasculares: mecanismos subjacentes, riscos a longo prazo e estratégias de prevenção
Authors: Nandi Isabella Garcia , Leão Ângelo Augusto Stoll , Coelho Beatriz Baldon , Soares Laura Lustosa , Girardi Nicole Ries
Published: September 2024

A hipertensão durante a gravidez, que inclui condições como hipertensão gestacional e pré-eclâmpsia, é uma preocupação significativa que impacta tanto a saúde materna quanto a fetal e pode ser um indicador precoce de doenças cardiovasculares a longo prazo. Este artigo examina os mecanismos subjacentes que conectam a hipertensão na gravidez ao desenvolvimento de doenças cardiovasculares crônicas, com base em uma análise detalhada da literatura atual. A disfunção endotelial e a inflamação são identificadas como processos cruciais que contribuem para a transição de hipertensão gestacional para condições cardiovasculares crônicas. O risco aumentado de eventos cardiovasculares graves, como infarto do miocárdio e acidente vascular cerebral, em mulheres com histórico de hipertensão gestacional, destaca a importância de um monitoramento e intervenções precoces. Estratégias de manejo contínuo e personalizado, tanto durante a gravidez quanto no pós-parto, são essenciais para mitigar esses riscos. O artigo também discute as melhores práticas e diretrizes internacionais para o tratamento de hipertensão na gravidez, enfatizando a necessidade de uma abordagem integrada e contínua para o cuidado da saúde cardiovascular das mulheres. Além disso, a revisão inclui uma discussão sobre as recomendações para estratégias de prevenção e manejo, que são fundamentais para reduzir o impacto a longo prazo da hipertensão na gravidez. A combinação de medidas preventivas e intervenções adequadas é crucial para minimizar os riscos associados e melhorar os resultados de saúde a longo prazo para essas pacientes.
Colangiocarcinoma: tratamento cirúrgico
Authors: Abib Rafaela Lins , Gurgel Ana Beatriz Silva Steffens , Soares Carolina Bojikian , Merici Franco , Monteiro Gabriele Vieira , Fazzolari Giovanna Sousa , Formigari Isabella Ferreira , Corrêa Wagner Pablo
Published: September 2024

O presente trabalho abordou os diferentes tratamentos do colangiocarcinoma (CCA) de acordo com suas particularidades. Cirrose, colangite esclerosante primária, hepatite viral e cálculos biliares recorrentes estão entre os fatores de risco do CCA. Essa neoplasia maligna pode se diferenciar conforme sua localização, sendo classificada como intra-hepática, perihilar e extra-hepática. O manejo dessa doença varia conforme suas características e pode ser feito por meio de ressecção cirúrgica comlinfadenectomia, terapia sistêmica e tratamento com bomba de infusão arterial hepática. A escolha do melhor método terapêutico depende doestadiamento e condições clínicas do paciente.. Novos estudos devem ser realizados , a fim de promover diagnóstico precoce e terapêuticas mais efetivas para propiciar melhores desfechos clínicos.
Análise de coorte de Acidente Vascular Cerebral em pacientes jovens – Hospital Julio C. Perando - 2018
Authors: Benetti Jordan , Tomazzi Larissa Calderan
Published: September 2024

O Acidente Vascular Cerebral (AVC) é a terceira causa de morte e a primeira causa de incapacidade em adultos no mundo diante desse problema de saúde pública tem como objetivo deste trabalho obter a incidência, idade, sexo, presença de fatores de risco e tipo de AVC em pacientes que foram atendidos no serviço de neurologia do Hospital J.C. Perrando durante o ano de 2018. Foram analisadas todas as historias clínicas dos pacientes atendidos no serviço de neurologia clínica do Hospital J. C. Perrando no ano de 2018. Foram seleccionados os pacientes com o diagnóstico de ACV com idade menor ou igual a 50 anos. Da casuística estudada, um total de 33 pacientes foram analisados. Assim, foi obtida a incidência de pacientes com a doença no ano de 2018, o tipo de AVC, idade e gênero mais frequente com presença ou ausência de fatores de risco para AVC. Com o presente trabalho obtemos a idade média de apresentacão de ACV em pacientes jovens foi de 40 anos, onde o sexo femenino representa a maioria dos casos. O tipo de AVC mais frequente nesses pacientes foi o isquêmico  com fatores de risco associados. Os dados obtidos no trabalho coinciden com estatísticas de estudos prévios, para uma maior precisão deveria realizar uma analise com um período de tempo mais prolongado.
Fatores de risco para alterações em Testes do Olhinho: estudo caso-controle
Authors: Souza Neto Jonas Alves de , Giovani Alessandro Rogerio , Krein Joana Haab , Galvão Suzane Santos , Souza Tharleton Ribeiro de , Souza Vinícius Sant’Ana de , Borges Fábio Vieira de Andrade , Crepaldi Tânia Crepaldi de Oliviera Mendes
Published: September 2024

O teste do olhinho (TO) consiste em um exame de triagem realizado em recém-nascidos (RN) para identificar problemas oculares congênitos que podem comprometer a visão. A detecção precoce destas condições é fundamental na prevenção e tratamento de diversas causas de cegueira infantil. Objetiva-se investig      ar possíveis correlações entre alterações nos resultados do TO e variáveis relacionadas à parturiente, gestação e parto. Para tanto, um estudo caso-controle retrospectivo foi realizado com amostra composta de 219 binômios mãe-filho, pacientes da rede pública, encaminhados para a realização do Teste do Reflexo Vermelho em clínica particular na cidade de Rio Verde – GO, Brasil. Durante o período de dezembro/2022 a março/2023 foram aplicados questionários aos responsáveis dos RN, correlacionando as variáveis analisadas aos resultados dos TO. Desse modo, observa-se que dos 219 testes realizados, 13 apresentaram resultado alterados. A média de idade materna foi de 26,3 anos. Cerca de 58,3% das gestantes apresentaram alguma infecção durante o período gestacional, sendo a infecção do trato urinário a mais prevalente. Tais resultados nos permite concluir que não há correlações estatisticamente significantes entre as variáveis controladas e as alterações no TO. O estudo demonstrou algumas restrições na coleta de informações e destacou a necessidade de mais investigação para um melhor entendimento desse campo.
Risco microbiológico em sistemas de ar condicionado: um estudo em instituições de saúde em Garanhuns-PE
Authors: Santos Amanda Emily Alves dos , Cavalcanti Anna Carolyna Ferraz Menezes , Fontenele Sara Fernandes , Amorim Yasmin Ayana Ximenes , Nascimento Junior José Adelson Alves do
Published: September 2024

Justificativa/Problema: A formação de biofilmes bacterianos nos sistemas de ar condicionado de instituições de saúde representa um risco significativo à saúde pública, devido à disseminação de microrganismos patogênicos e à maior incidência de Infecções Relacionadas à Assistência à Saúde (IRAS). Objetivos: Este estudo objetiva investigar a presença de microrganismos nos filtros de ar condicionado em instituições de saúde no município de Garanhuns em Pernambuco e estabelecer a relação entre as condições de manutenção desses equipamentos e a incidência de IRAS. Metodologia: Foram coletadas amostras dos filtros de ar condicionado em diversas instituições de saúde em Garanhuns-PE. As amostras foram submetidas a análises microbiológicas para identificar os microrganismos presentes. Também foram avaliadas as condições de manutenção e limpeza dos sistemas de ar condicionado, incluindo a periodicidade das intervenções e a eficácia dos métodos utilizados. Resultados: A análise microbiológica revelou uma forte presença de bactérias gram-positivas, como Staphylococcus aureus, Staphylococcus epidermidis e Streptococcus pneumoniae, em todas as amostras. A presença de biofilme bacteriano nesses sistemas aumenta a resistência aos métodos tradicionais de limpeza, elevando o risco de infecções respiratórias e alérgicas. Conclusão: A manutenção inadequada dos sistemas de ar condicionado em instituições de saúde de Garanhuns contribui para a alta prevalência de bactérias patogênicas, aumentando o risco de IRAS. Medidas rigorosas de limpeza e desinfecção, juntamente com tecnologias avançadas de purificação de ar, são essenciais para garantir a segurança do ambiente hospitalar.
Hidatidose hepática: uma revisão de literatura dos padrões radiológicos
Authors: Moreira Talita Vasconcelos dos Santos , Memória Thiara Castro de Oliveira
Published: September 2024

As espécies do gênero Echinococcus são responsáveis por causar doenças císticas em animais e humanos. Esse gênero atualmente contém cerca de 9 espécies divididas em linhagens/genótipos de hospedeiros definitivos e intermediários, sendo responsáveis por causar, em seres humanos a hidatidose/equinococose cística, policística e alveolar. Nos hospedeiros intermediários, os humanos são acometidos por dor no local em que o parasita está presente, geralmente este se localiza no pulmão e/ou fígado, causando êmese frequente, edema, desconforto abdominal e dispnéia, inicialmente. Quando há o rompimento do cisto hidático, poderão surgir outras complicações que colocam em risco a vida do paciente. Este parasita se desenvolve de forma lenta, podendo permanecer por vários anos de forma assintomática, dificultando o diagnóstico. Essa doença exige uma abordagem multidisciplinar, com diagnóstico feito por meio da análise dos sinais e sintomas, salientando-se a importância dos métodos de imagem, juntamente com o papel que os médicos radiologistas desempenham para a elucidação diagnóstica. O objetivo deste trabalho é realizar uma revisão da hidatidose, suas formas e ciclo de transmissão, dando ênfase na sua apresentação hepática, sinais e sintomas, métodos de diagnóstico por imagem e as apresentações radiológicas da doença.
Ultrasensitive Terahertz Label-Free Metasensors Enabled by Quasi-Bound States in the Continuum
Authors: Wang Ride , Song Lingyu , Ruan Hao , Yang Quanlong , Yang Xiao , Zhang Xiaobao , Jiang Rundong , Shi Xiangmin , Shkurinov Alexander P.
Published: September 2024

Advanced sensing devices based on metasurfaces have emerged as a revolutionary platform for innovative label-free biosensors, holding promise for early diagnostics and the detection of low-concentration analytes. Here, we developed a chip-based ultrasensitive terahertz (THz) metasensor, leveraging a quasi-bound state in the continuum (
q-
BIC) to address the challenges associated with intricate operations in trace biochemical detection. The metasensor design features an open-ring resonator metasurface, which supports magnetic dipole
q
-BIC combining functionalized gold nanoparticles (AuNPs) bound with a specific antibody. The substantial enhancement in THz–analyte interactions, facilitated by the potent near-field enhancement enabled by the
q
-BICs, results in a substantial boost in biosensor sensitivity by up to 560 GHz/refractive index units. This methodology allows for the detection of conjugated antibody–AuNPs for cardiac troponin I at concentrations as low as 0.5 pg/ml. These discoveries deliver valuable insight for AuNP-based trace biomolecule sensing and pave the path for the development of chip-scale biosensors with profound light–matter interactions.
Open access nationwide data sets for drinking water hardness at public waterworks and their water supply areas in Denmark
Authors: Voutchkova Denitza D , Thomsen Charlotte T , Claes Niels , Olsen Lars A , Thorling Lærke , Pjetursson Bjarni , Hansen Birgitte
Published: September 2024

Three spatiotemporal data sets of drinking water hardness in Denmark (version 1) are presented here: (1) annual drinking water hardness at public waterworks (1905–2023); (2) annual drinking water hardness at their water supply areas (1978–2023) and (3) the latest drinking water hardness at the water supply areas (1980–2023). Raw data were extracted from the Jupiter database for groundwater and drinking water data in Denmark, and were quality-assured. Hardness was calculated after semi-automatic outlier exclusion based on Ca and Mg, or if not available, the reported total hardness. Data were further aggregated at the waterworks level by the annual mean and at the supply area level by the weighted mean (weighted to waterworks annual abstraction volumes). Temporal and spatial gaps were filled prior to these aggregations. Various stakeholders could benefit from these open access data. They provide a societal service in response to increased public interest in drinking water hardness. The research community could use the data in environmental, exposure or epidemiological assessments. Finally, the water supplies and the public sector could benefit from these data as they provide a nationwide overview of current and past drinking water hardness in Denmark and highlight the geographic areas that lack recent data, most probably due to de-regulation.
THE ABILITIES OF A PSYCHOTHERAPIST AS THE BASIS OF HIS EMOTIONAL COMPETENCE
Authors: Goncharov M.A. , Vannovskaya O.V.
Published: September 2024

The article contains an analysis of various approaches to studying the emotional competence of psychotherapists and its role in building therapeutic relationships. The work presents the most common contemporary approaches to describing the personality traits underlying emotional intelligence. Theoretical and empirical research has expanded these concepts and described nine abilities of psychotherapists necessary for creating an atmosphere of emotional safety and establishing “helping” relationships. The results of an empirical study involving 71 psychotherapists are presented, leading to the conclusion that it is possible to enhance the emotional competence of psychotherapists through specialized training programs.
Development Of Phage Therapy Strategies Against Gram-positive Bacterial Pathogens
Authors:   ,   Munster Technological University, Arroyo Moreno Sara
Published: September 2024

Bacterial resistance to conventional antibiotics has become an urgent healthcare issue worldwide. In this light, a renewed interest has emerged for therapy with bacteriophages (phages), which are viruses that can specifically infect bacteria. These viruses encode different proteins that degrade specific bonds within the bacterial cell wall, both to inject their genomic material into the bacterial cells and to release the viral progeny: virion-associated hydrolases and endolysins, respectively. Elimination of Gram-positive pathogens with recombinant versions of phage enzymes represents a promising alternative to classical antibiotics. In this thesis, different phage therapy strategies involving either whole phages or the use of recombinant versions of endolysins are developed against different Gram-positive bacteria. Firstly, two novel phages targeting Staphylococcus aureus were isolated from a therapeutic cocktail and some phage Open Reading Frames with unknown function were studied for their implications in bacterial host range. Genomic analysis of the Irish MRSA collection was carried out to understand their different susceptibilities to different phages. An engineered staphylococcal endolysin was developed with enhanced antibiofilm activity. Other Gram-positive pathogens such as Gardnerella vaginalis and Clostridium difficile were also subject of study in this thesis, and novel endolysins targeting them were obtained and characterized.
Investigating The Antioxidant, Immunomodulatory And Anti-obesogenic Propertiesof Novel Bsg-derived Extracts And Their Potential As Ingredients In Functional Foods For Older Adults
Authors:   ,   Munster Technological University, O Brien Suzanne
Published: September 2024

Brewer’s Spent Grain (BSG) represents a substantial waste product of the brewing industry, with 39 million tonnes generated globally every year. To date the primary use of BSG is as animal feed but there is significant interest in identifying alternative uses for this agroindustry by-product. BSG is rich in protein and fibre and is known to contain healthpromoting bioactive compounds, thus one application would be in the area of functional foods. People are living longer and as the older adult population continues to increase globally so too is the prevalence of age-related chronic conditions. Diet plays an essential role in healthy ageing and there is currently an increased demand for more convenient, affordable and healthy food options for the elderly cohort. This research aims to help reduce the environmental burden of brewery waste and add to the global demand for innovative functional food products for older adults, by investigating the bioactivity of BSG. Novel BSG fractions were generated, digested with a simulated gastrointestinal in vitro digestion (SGID) system and then screened for a range of bioactivities. The potential antioxidant, immunomodulatory and anti-obesogenic properties of the digestates were investigated using cellular and non-cellular assays. BSG-derived fractions that had significantly improved (p<0.05) antioxidant properties were identified. Anti-obesity investigations revealed that all BSG fractions significantly reduced (p<0.05) adipocyte differentiation in vitro, but none of the fractions inhibited lipase activity. The anti-obesity properties of BSG have not been previously investigated. Data from this study provides additional knowledge on the bioactive properties of BSG and gives additional value to brewing co-products. The fractions generated in this study will support the use of BSG and BSG-derived fractions as ingredients in the design of functional foods.
The evolution of transnational sustainability governance through a systems theory lens: From rejection to acceptance of business responsibilities for human rights
Authors: Buhmann Karin
Published: September 2024

This article applies Luhmann’s systems theory approach to the argumentative dynamics of the processes and outcomes of key UN and EU initiatives during the decade 2002-2011 in regard to the development and acceptance of human rights responsibilities for business enterprises. That decade saw a change from rejection to welcoming of ideas on such responsibilities as a key social sustainability issue. Demonstrating the use of systems theory to empirical cases, the article shows how the systems theory perspective generates important insights on communicative aspects of a regulatory process towards a normative change in contexts with multiple and diverse interests at play in today’s legal order where the transnational character of many sustainability problems exceeds the nation state. The article fills a knowledge gap concerning processes for governing transnational sustainability issues, where the territorial limits of national public law and the weak private-actor coverage of international law pose challenges to conventional regulation.
Este artículo aplica el enfoque de la teoría de sistemas de Luhmann a la dinámica argumentativa de los procesos y resultados de iniciativas clave de la ONU y la UE durante la década 2002-2011 en relación con el desarrollo y la aceptación de las responsabilidades de las empresas en materia de derechos humanos. En esa década se pasó del rechazo a la aceptación de las ideas sobre dichas responsabilidades como cuestión clave de la sostenibilidad empresarial. Aplicando la teoría de sistemas a estos casos empíricos, el artículo demuestra que la perspectiva de la teoría de sistemas es capaz de aportar importantes conocimientos sobre los aspectos comunicativos de un proceso regulador hacia un cambio normativo en contextos con múltiples y diversos intereses en juego. Tales procesos pueden desempeñar un papel importante cuando el carácter transnacional de los problemas de sostenibilidad sobrepasa al Estado nación, y los límites territoriales del derecho público nacional y la escasa cobertura del derecho internacional por parte de los actores privados plantean retos a la regulación convencional. Partiendo de este reto, y basándose en el análisis empírico, el artículo contribuye a la erudición emergente sobre cómo pueden gobernarse los problemas transnacionales de sostenibilidad.
Il Museo di Paleontologia dell’Università di Catania: origine e storia
Authors: Alberghina Mario , Rosso Antonietta , Sanfilippo Rossana , Di Geronimo Sebastiano
Published: September 2024

Al meglio delle fonti documentarie a disposizione, sono state ricostruite le tappe migratorie delle collezioni paleontologiche del Museo di Paleontologia dell’Università di Catania. In aggiunta è stata ricostruita la storia personale dei curatori che hanno assistito e diretto, con maggiore responsabilità e professionalità, il continuo riassetto dei campioni fossili nelle sale espositive. Nuove allocazioni hanno interessato l’antico Palazzo dell’Università nell’Ottocento e primo Novecento, e il nuovo Palazzo delle Scienze nel secondo Novecento fino a oggi. Avvalendosi di risorse economiche fornite da Progetti nazionali di riordino organizzativo e promozione della scienza sono state avviate molte novità espositive nelle collezioni del Museo.
PHENOTYPE VARIATION, CORRELATION, AND REGRESSION OF MORPHOLOGY CHARACTERISTICS IN RAMS AND EWES GARUT INDONESIAN LOCAL SHEEP
Authors: Mudawamah Mudawamah , N. Hairoh  , Fadli M.Z. , Lestari M.W. , Afroni M.Y. , Y. Oktanella  , G. Ciptadi
Published: September 2024

This research was conducted to examine phenotypic variation, correlation, and regression of various morphometric characteristics in Garut sheep, as a basis for consideration in selecting prospective candidate rams and ewes. The method used in this research was a case study, with the sample criteria of ewes having at least one kid and rams having offspring. Malang Regency farmer conducted this research with a total sample of 27 Garut Sheep as a Javanese thin-tail. The five standard morphological traits observed were body length (BL), chest circumference (CC), body height (HG), height hip (HH), and width hip (WH). Data analysis used analysis of variance with a single factor to characterize the morphology of rams and ewes of Garut Indonesian Local sheep. The results showed that BL and BH of rams were significantly different (P < 0.05) higher than the ewes, with no significant difference (P > 0.05) in CC, HH, HW, and TL of ewes and rams, but CC and HH tended to be higher in ram than ewes; in contrast, HW and TL mean tended to be lower in ram than ewes. Variation or diversity, correlation, and determination coefficient in all morphological traits ranged from 4.86 to 47.10, 0.41 to 0.74, and positive regression in rams and ewes. The conclusion was that 67% of morphological traits (CC, BL, BH, and HH) were higher in Rams than in Ewes and lower than 33% of HW and TL. The closest correlation of morphology in both rams and ewes was the relationship between BL (X) and CC (Y), with a determination coefficient of 43-55% and the regression equation Y = 35.64 + 0.51 X (rams) and Y = 14.86 + 0.70 X.