bluuebunny/crossref_metadata_2025 huggingface dataset:
MATHEMATICAL MODELING IN COMPUTER TOMOGRAPHY BY NEW INFORMATION OPERATORS
Authors: Pershyna Iuliia , Ptashniy Oleg
Published: April 2023

In the paper the methods of restoring the internal structure of the object, using new information operators developed by the Ukrainian scientist Professor Lytvyn O.M., namely, interlineation and interflatation, are studied. Interlineation and interfltatation operators restore functions (perhaps approximately) according to their known traces on a given system of lines and planes, respectively. The paper provides a solution to the three-dimensional computer tomography problem by the function interpolation operator. Tomograms obtained from a real computer tomograph and the equations of the planes on which these tomograms lie serve as experimental data. The paper considers the problem of restoring the absorption coefficient inside a three-dimensional object based on its tomograms lying on a system of three groups of parallel planes, which are not necessarily perpendicular to the coordinate axes. In addition, an interflatation operator is constructed on a system of planes, each of which does not necessarily intersect with all others. A method for restoring the internal structure of a three-dimensional body is also being developed, which uses four tomograms and is built using the interpolation of functions of three variables. Also, the paper presents the general forms of densities or absorption coefficients of objects, which are described by functions that can be accurately restored with the help of the specified information. In the work, a method of restoring the internal structure of the body is developed using the operator of blending approximation by Bernstein polynomials. This method is recommended to be used in cases when the experimental data (characteristics of tomograms – geometric parameters of the plane on which the tomogram lies, as well as images on the tomograms) are given with an error, and when the classic interpolation and interfltation operators do not smooth the data, but repeat all the errors in experimental data. Further, the developed new information operators are used to restore a dynamic body. In this paper, the problem of two-dimensional computer tomography is solved not only with the use of new information operators, but also the heterogeneity of the internal structure of the examined body. All proposed methods have high accuracy.
PROBABILISTIC MODEL OF ION FLOW ACROSS THE MEMBRANE
Authors: Tonitsa Oleg , Serdyuk Irina , Gelyarovska Oksana , Protsai Natalya , Vasylets Eduard
Published: April 2023

It is proposed to study the qualitative impact of electromagnetic fields on the membrane of plant tissue for preservation and delivery of them fresh to the final consumer. Spherical apple fruits were exposed to the influence of electromagnetic fields on the cell membrane. Ukraine is an industrial-agrarian country with a predominance of raw material production. It is one of the leading exporters of some types of agricultural products. The large number of fertile lands of our country indicates that Ukraine should be a full-fledged exporter of agricultural goods to the countries of Europe and the world. At the same time, two main problems arise: the production of quality agricultural products by farmers and their preservation for a long time in a fresh form. It is very important that the final consumer receives the product fresh and tasty.

The freshness of a product is preserved by freezing and keeping it at a temperature below minus 20 degrees Celsius. However, this method is not suitable when it comes to fresh fruit. Therefore, the object of research for a number of scientists was the influence of external electromagnetic fields on the process of preserving fruit and berry products. It was established that the membrane potential of the cell at the moment of physiological rest is important for the preservation of product freshness. It is at this moment that the metabolism is in balance. At the same time, the Krebs respiration cycle is used, which was discovered for animals, but was later proven in plants as well. The issue of researching the qualitative impact of electromagnetic fields on the membrane of plant tissue in order to preserve and deliver them fresh to the final consumer is very important and relevant. For example, it is possible to expose apple fruits, which have the shape of a sphere, to the influence of electromagnetic fields on the cell membrane.

The most important factor that affects the processes of growth and development of plants is known to be light, its direction, as well as its qualitative and quantitative characteristics. However, not everyone knows that there are two more environmental factors that have received little attention so far, and that are not always taken into account when analyzing the physiology of the plant organism. These factors are the electric field of the atmosphere, as well as the electromagnetic field of the Earth. At the same time, artificial external electromagnetic fields can affect fruits, both positively and negatively. The electrophysical characteristics of these fields determine the result of this influence. These are voltages, frequency, method of modulation, exposure, etc. The methods of storing of agricultural products are presented based on the presence in the fruit storage of electromagnetic field of ultra high frequency in the range 33,5–36 GHz, which blocks the ion channels and increases the fruit shelf life by up to seven times.
Pendidikan, Human Capital ataukah Signaling? Studi Kasus Indonesia
Authors:   Departemen Ilmu Ekonomi Universitas Padjadjaran, Fahmi Mohamad , Mulyono Yeni Oktavia ,   Kementerian PPN/Bappenas
Published: April 2023

Studi ini bertujuan untuk menguji apakah perilaku masyarakat Indonesia dalam memandang pendidikan merupakan perwujudan dari teori human capital ataukah teori signaling. Dengan menggunakan model Ordinary Least Square (OLS) dan data Indonesia Family Life Survey (IFLS) tahun 2007, penulis menemukan bahwa kedua teori tersebut mempunyai pengaruh yang sama dalam memengaruhi perilaku masyarakat Indonesia dalam menempuh pendidikan.
Pengaruh Defisit Fiskal terhadap Pertumbuhan Ekonomi di Indonesia Periode 1990-2012
Authors:   Kementerian Keuangan Republik Indonesia, Swasono Dwinanda Ardhi , Martawardaya Berly ,   Fakultas Ekonomi dan Bisnis Universitas Indonesia
Published: April 2023

Studi ini dilakukan untuk mengetahui pengaruh defisit fiskal terhadap pertumbuhan ekonomi di Indonesia tahun 1990-2012. Kontribusi studi ini adalah pengunaan metode kointegrasi dengan Error Correction Model. Kami mengonfirmasi hipotesa teori dan menemukan defisit fiskal berdampak positif dan signifikan terhadap pertumbuhan ekonomi. Pemerintah disarankan untuk mengambil kebijakan fiskal yang ekspansif dengan memperhatikan undang-undang Anggaran Pendapatan dan Belanja Negara yang menetapkan maksimal defisit sebesar 3%.
PENILAIAN ESTETIKA AKSESORIS KALUNG BERBAHAN DASAR POLYMER CLAY
Authors: Chairat Yunia , Noerharyono Noerharyono , Suliyanthini Dewi , Noerharyono Moehamad. , Radiona Vivi
Published: April 2023

Penelitian ini bertujuan membuat produk aksesoris kalung berbahan dasar polymer clay yang kemudian dinilai oleh panelis ahli berdasarkan penerapan unsur desain yaitu dari aspek unsur bentuk, unsur warna, dan unsur tekstur. Sedangkan penerapan prinsip desain yaitu dari aspek prinsip harmoni, prinsip proporsi, dan prinsip irama. Metode yang digunakan adalah kuantitatif deskriptif, dengan desain pre–experimental, model one-shot case study, dan eksperimen berupa 5 buah produk aksesoris kalung berbahan dasar polymer clay yang terinspirasi dari bentuk hasil sulaman teknik soutache dengan jenis kalung princess. Data penelitian diperoleh dari instrumen penilaian yang diberikan kepada 5 orang panelis ahli, dan penilaian diukur menggunakan skala bertingkat Rating Scale dengan skala 1-4. Hasil penelitian dari indikator unsur desain mendapat nilai 3.448 dengan persentase nilai 86.2% termasuk kedalam kategori sangat baik. Sementara pada indikator prinsip desain mendapatkan nilai 3,34 dengan persentase nilai 83.5% termasuk kedalam kategori sangat baik. Hasil keseluruhan mendapatkan nilai sebesar 3.38 dan persentase nilai sebesar 84.5 % menunjukkan aksesoris kalung mendekati skala sangat baik. Nilai akhir tertinggi berdasarkan desain aksesoris kalung diperoleh desain ke 3 dengan nilai sangat baik yaitu 88,69%, sedangkan nilai terendah diperoleh desain aksesoris kalung ke 2 dengan nilai 80,9%.
REHABILITACIÓN ENERGÉTICA DE ESCUELA RURAL EN SANTIAGO DEL ESTERO-ARGENTINA: EVALUACIÓN DEL CONFORT HIGROTÉRMICO
Authors:   Universidad Nacional de Santiago del Estero, Giuliano Raimondi Gabriela María del Carmen , Saganias Julieta , Thomaschewsky Luciana , Garzón Beatriz ,   Universidad Nacional de Tucumán, Ferreiro Alejandro
Published: April 2023

In this paper, we propose the hygrothermal comfort analysis of a rural educational building in a dispersed settlement, located southeast of the province of Santiago del Estero, in the town of Las Viboritas, department of Mitre, in Norte Grande, Argentina. A methodological, descriptive, experimental, and analytical combination was used for the diagnosis of the behavior of the case study. The state prototype, called the base case, is diagnosed with poor thermal performance. Therefore, an alternative to improve the energy rehabilitation of the envelope is proposed. Both cases were evaluated comparatively, with the adjustment of thermal simulations and the verification of calculation values with the admissible ones established in the series of IRAM Standards on thermal conditioning. The analysis of the empirical and theoretical data obtained, allowed us to observe that the improved case responds optimally to the thermal-energetic behavior, achieving adequate interior comfort parameters in classrooms. In conclusion, the evaluation and design adjustment in state school projects prior to the construction stage, is essential for compliance with minimum quality standards, by the agencies responsible for their production; to contribute to the building energy efficiency of the school habitat and favor environmental sustainability in unfavorable areas and the human development of its inhabitants.
When to Perform Fusion Short of the Pelvis in Patients with Cerebral Palsy?
Authors: Badin Daniel , Baldwin Keith D. , Cahill Patrick J. , Spiegel David A. , Shah Suken A. , Yaszay Burt , Newton Peter O. , Sponseller Paul D.
Published: April 2023

Background:

Patients with scoliosis secondary to cerebral palsy (CP) are often treated with posterior spinal fusion (PSF) with or without pelvic fixation. We sought to establish criteria to guide the decision of whether or not to perform fusion “short of the pelvis” in this population, and to assess differences in outcomes.

Methods:

Using 2 prospective databases, we analyzed 87 pediatric patients who underwent PSF short of the pelvis from 2008 to 2015 to treat CP-related scoliosis and who had ≥2 years of follow-up. Preoperative radiographic and clinical variables were analyzed for associations with unsatisfactory correction (defined as pelvic obliquity of ≥10°, distal implant dislodgement, and/or reoperation for increasing deformity at 2- or 5-year follow-up). Continuous variables were dichotomized using the Youden index, and a multivariable model of predictors of unsatisfactory correction was created using backward stepwise selection. Finally, radiographic, health-related quality-of-life, and clinical outcomes of patients with fusion short of the pelvis who had neither of the 2 factors associated with unsatisfactory outcomes were compared with those of 2 matched-control groups.

Results:

Deformity correction was unsatisfactory in 29 of 87 patients with fusion short of the pelvis. The final model included preoperative pelvic obliquity of ≥17° (odds ratio [OR], 6.8; 95% confidence interval [CI], 2.3 to 19.7; p < 0.01) and dependent sitting status (OR, 3.2; 95% CI, 1.1 to 9.9; p = 0.04) as predictors of unsatisfactory correction. The predicted probability of unsatisfactory correction increased from 10% when neither of these factors was present to a predicated probability of 27% to 44% when 1 was present and to 72% when both were present. Among matched patients with these factors who had fusion to the pelvis, there was no association with unsatisfactory correction. Patients with independent sitting status and pelvic obliquity of <17° who had fusion short of the pelvis had significantly lower blood loss and hospital length of stay, and better 2-year health-related quality-of-life scores compared with matched controls with fusion to the pelvis.

Conclusions:

In patients with scoliosis secondary to CP, pelvic obliquity of <17° and independent sitting status are associated with a low risk of unsatisfactory correction and better 2-year outcomes when fusion short of the pelvis is performed. These may be used as preoperative criteria to guide the decision of whether to perform fusion short of the pelvis in patients with CP.

Level of Evidence:

Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
The Tsukamoto Fuzzy Method for Predicting the Availability Status of Goods Inventory Based on Identification with RFID Technology
Authors: Sungkono Arif , Handayani Untari Ningsih Dewi
Published: April 2023

Data collection of goods entering and leaving the warehouse is very important. However, in large companies with hundreds of items being traded, manual recording can take a long time. To solve this problem, an RFID reader is used to record the name of the goods in the warehouse. By using RFID, the recording time can be reduced. Combined with the application of the Tsukamoto fuzzy algorithm, the system can predict the amount of inventory in the coming month to create sufficient inventory or not excess or less and the company can obtain optimal profits due to the process of buying and selling goods. This study aims to create an inventory system that can record goods through scans and can predict inventory in the coming month. The method used in this research is RFID technology and the Fuzzy Tsukamoto method. The results of this study indicate that the application can scan incoming or outgoing goods tags using RFID technology. The system can also predict the amount of inventory in the coming month using the Tsukamoto fuzzy method.
Rub-impact fault identification of a bladed rotor based on chaotic features
Authors: Kou Haijiang , Yue Chaoyu , Lee Heow Pueh , Zhang Tao , Du Jiaojiao , Zhu Zhida , Zhang Fan , Zeng Li
Published: April 2023

The bladed rotor is an important part in turbine machines. Timely detection of its blade rubbing fault may avoid serious accidents. This paper developed a rub-impact fault identification approach for the bladed rotor based on chaotic features such as average period, time delay, embedded dimension, and largest Lyapunov exponent. A dynamic analytical model of a rotating variable thickness blade with the rub-impact fault is established. It is verified that the blade rubbing model could obtain the relationship between the chaotic behaviors and the rub-impact fault for a rotating blade. Through the nonlinear characteristic analysis, we could establish that different blade rubbing states have a certain corresponding relationship with the chaotic characteristics, which provides the theoretical basis for the blade rubbing identification using the chaotic features. In particular, a rub-impact fault identification approach based on chaotic features is further studied. And the blade rubbing fault can be easily identified by combining four chaotic features, which is proven by experiments. Comparing with the time domain and frequency domain analysis methods, the proposed approach provides a new way to identify such blade rubbing fault.
Danish Population Based Study of Familial Epilepsy and Childhood Cancer
Authors: Platamone Corbin , Huang Xiwen , Mazumder Rajarshi , Ritz Beate , Olsen Jorn , Hansen Johnni , Saechao Chai , Heck Julia E
Published: April 2023

Objective: Results from studies investigating the association between maternal or child epilepsy, use of anticonvulsants in pregnancy, and childhood cancer are inconsistent and at times contradictory.
Methods: Linking Danish national databases, we obtained epilepsy and childhood cancer diagnoses, and anticonvulsant use data. We estimated adjusted odds ratios of all or specific childhood cancers in relation to maternal or child epilepsy and anticonvulsant therapies using conditional logistic regression.
Results: Maternal epilepsy was positively associated with all childhood cancers in offspring, specifically, with acute lymphoblastic leukemia (Odds Ratio (OR) = 1.68, 95% Confidence Interval (CI) = 1.16, 2.43) and Wilms tumor (OR = 2.13, 95%CI = 0.97, 4.68). When considering maternal ever (lifetime) ingestion of anticonvulsants, a positive association was found with all cancers (OR = 1.15, 95%CI = 1.01, 1.31), and central nervous system tumors (OR = 1.32, 95%CI = 1.03, 1.69) as well as neuroblastoma (OR = 2.05, 95%CI = 1.29, 3.28) among offspring. Maternal anticonvulsant use before or during the index pregnancy was related to CNS tumors in offspring (OR = 1.78, 95%CI = 0.99, 3.21), however the confidence interval included the null.
Significance: Maternal use of certain anticonvulsant medications may be a risk factor for cancer in offspring. Medical providers may need to consider what type of treatments to prescribe to pregnant mothers with epilepsy.
Single fluorogen imaging reveals spatial inhomogeneities within biomolecular condensates
Authors: Pappu Rohit , Wu Tingting , King Matthew , Farag Mina , Lew Matthew
Published: April 2023

Recent investigations have suggested that biomolecular condensates are viscoelastic materials. This implies that material properties of condensates are governed by internal microstructures. Furthermore, computations show that the internal organization in protein condensates is spatially inhomogeneous, featuring hub-and-spoke-like percolated networks of molecules. Here, we test these predictions using imaging of single fluorogenic dyes that are turned-on in response to specific chemical microenvironments. We deployed Nile blue (NB), Nile red (NR), and merocyanine 540 (MC540) for epifluorescence and single-molecule localization microscopy imaging of condensates formed by intrinsically disordered, low-complexity domains of proteins. Imaging with NB reveals internal environments that are uniformly hydrophobic, whereas NR shows preferential binding to hubs that are more hydrophobic than the surrounding background within condensates. Finally, imaging with MC540 suggests that interfaces of condensates are unique chemical environments. Overall, the high spatiotemporal resolution and environmental sensitivity of single-fluorogen imaging reveals spatially inhomogeneous organization of molecules within condensates.
VOLTA: an Environment-Aware Contrastive Cell Representation Learning for Histopathology
Authors: Nakhli Ramin , Zhang Allen , Farahani Hossein , Darbandsari Amirali , Shenasa Elahe , Thiessen Sidney , Milne Katy , McAlpine Jessica , Nelson Brad , Gilks Blake , Bashashati Ali
Published: April 2023

In clinical practice, many diagnosis tasks rely on the identification of cells in histopathology images. While supervised machine learning techniques require labels, providing manual cell annotations is time-consuming due to the large number of cells. In this paper, we propose a self-supervised framework (VOLTA) for cell representation learning in histopathology images using a novel technique that accounts for the cell's mutual relationship with its environment for improved cell representations. We subjected our model to extensive experiments on the data collected from multiple institutions around the world comprising of over 700,000 cells, four cancer types, and cell types ranging from three to six categories for each dataset. The results show that our model outperforms the state-of-the-art models in cell representation learning. To showcase the potential power of our proposed framework, we applied VOLTA to ovarian and endometrial cancers with very small sample sizes (10-20 samples) and demonstrated that our cell representations can be utilized to identify the known histotypes of ovarian cancer and provide novel insights that link histopathology and molecular subtypes of endometrial cancer. Unlike supervised deep learning models that require large sample sizes for training, we provide a framework that can empower new discoveries without any annotation data in situations where sample sizes are limited.
Biochemical Profile and Enzymatic Activity of Organs of Late-phase Laying Hens Fed Diet With Calcium Anacardate Associated With Citric Acid
Authors: Watanabe Germana Costa Aguiar , Watanabe Pedro Henrique , Melo Marcelle , Santos Edibergue , Cordeiro Carla , Freitas Ednardo Rodrigues
Published: April 2023

The aim of this study was to evaluate dietary inclusion of calcium anacardate (CAN) associated or not with citric acid (CA) in late-phase laying hen diets on serum biochemical profile, serum lipid peroxidation (TBARS), enzymatic activity (CAT and SOD) of liver, ovary, magnum and uterus. A total of 432 laying hens with 63 weeks of age were distributed into nine treatments and six replicates. Treatments consisted of: T1 – diet without additives; T2 – diet with 0.25%CAN; T3 – diet with 0.25%CAN + 0.25%CA; T4 – diet with 0.50%CAN; T5 – diet with 0.50%CAN + 0.25%AC; T6 – diet with 0.50%CAN + 0.50%CA; T7 – diet with 0.75%CAN; T8 – diet with 0.75%CAN + 0.25%CA; T9 – diet with 0.75%CAN + 0.50%CA. Lower serum TBARS was observed in birds fed 0.75% CAN and associate with AC (0.50% CAN + 0.50% CA). Dietary inclusion of CAN (0.50% and 0.75%) or associated with CA (0.25% and 0.50%) resulted in lower CAT in the liver and higher enzyme activity in the magnum. SOD activity in magnum was higher in laying hens fed diet without additives and lower values was observed considering increasing level of CAN. Dietary inclusion of CAN (0.75%) and its association with CA (0.50% CAN with 0.50 CA) for late-phase laying hens reduce serum peroxidation. Higher CAT activity was observed in magnum from the level of 0.50% CAN with or without CA. Increasing levels of CAN associated with CA results in lower CAT activity in the liver and SOD activity in reproductive tissues.
Plant Derived MicroRNA156: A Critical Regulator of Environmental Stress
Authors: Upadhyay Anam , Singhal Shivani , Bhardwaj Bhavya , Rani Vibha
Published: April 2023

Rice is the primary consumable crop of much of the Indian population. The use of hexavalent chromium (Cr IV) in various manufacturing industries has led to the contamination of the fields via effluents released in the water sources. MicroRNAs, crucial for various cellular processes, have been successfully detected in many plants with the prelude of Next Generation Sequencing (NGS). The objective of the presented study was to investigate the role of miRNAs as critical regulators of chromium toxicity in rice IR-64 species. Bioinformatic approaches were used to characterize the NGS data of root samples of Oryza sativa indica Cr (VI) toxicity. It was determined that metal stress in the rice sample modulated the regulation of several miRNAs but miR156 was found to be a crucial modulator in our study and was further characterized to expand on the recently developed idea of cross-kingdom relationships. Different assays were performed on H9C2 cardiomyocytes to examine the effect of chromium on the heart tissues since the accumulation of heavy metals in the human systems from diet has been established. Our research also indicated a substantial correlation between the physiological processes of growth and development under chromium stress and miRNA-targeted genes. Therefore, these results could serve as a foundation for future investigation into how miRNAs regulate biological processes.
Cemeteries as a source of environmental contamination: phytogenotoxicity of the biogenic amines cadaverine and putrescine
Authors: Braga Ana Paula Andrade , de Souza Letícia Rosa , Lima Maria Gabriela Franco , Gonçalves Matheus de Moraes Cunha , Marin-Morales Maria Aparecida
Published: April 2023

Among the compounds present in necro-leachate, a liquid released during the process of decomposition of the human body, are the biogenic amines cadaverine and putrescine. Although some studies on necro-leachate have indicated a potential ecotoxicological and public health risk associated with it, the research on this type of contamination is still rather limited. This study presents information about the phytotoxic and cytogenotoxic potential of cadaverine and putrescine, evaluated separately and within a mixture. Phytotoxicity was evaluated through a germination test, the initial growth of seedlings with Lactuca sativa, and cytogenotoxicity through chromosomal aberration and micronucleus tests with Allium cepa. The L. sativa results showed a phytotoxic effect for the evaluated amines, by reducing root (>90%) and hypocotyl (>80%) elongation. The co-exposure of cadaverine and putrescine potentiated cytogenotoxic activity by aneugenic action in the meristematic cells of A. cepa. From this result, it is possible to infer the eco-toxicogenic potential of cadaverine and putrescine amines and to emphasize the importance of further research in order to assess the risks of contamination generated in cemetery environments.
Computational Insights on the Impact of Allotypic Variation and Dimerization on Erap1 and Erap2 Structures Running Title: Structural Analysis of Erap1 and Erap2 Allotype Dimers
Authors: Dilek Yunus Emre , Kara İrem , Kıvrak Sena , Özkaya Şeyma Çolakoğlu , Erzik Can , Abacar Kerem Yiğit , Atagündüz Mehmet Pamir , Akcapinar Gunseli Bayram
Published: April 2023

Ankylosing Spondylitis is an autoimmune disease leading to inflammation in the joints and ligaments of the spine. ERAP1 is a major risk factor for AS and ERAP1 mutations may result in structural changes that alter the trimming efficiency, thereby altering the immune response. The underlying structural mechanisms of AS pathogenesis have not yet been fully elucidated. This study investigated ERAP1/ERAP2 allotypes using Molecular Dynamics in both monomeric and dimeric forms. ERAP1's domain IV has been found to be a favorable region for dimerization. Different allotype dimers exhibited different stability characteristics. Furthermore, the effects of allotypic variation were more pronounced in Hap2-/Hap8-coupled dimer structures and were more distinct in heterodimers. An analysis of the interchain region revealed that both H-bonding and electrostatic interactions between chains of Hap2–N392 heterodimer structures were lower than those between Hap2–Hap2 revealing that allotypic variations played a significant role in stabilizing and destabilizing dimer structures.
‎dimension of non-summand submodules
Authors: Alehafttan Alireza
Published: April 2023

‎We introduce and study the concept of essential Krull dimension as dual of small Krull dimension of a module‎, ‎which are defined in the same vein as Krull dimension of a module‎. ‎In particular‎, ‎we aim to show that there are some natural relations between the essential Krull dimension and the Krull dimension of an arbitrary module A‎. ‎We prove that if a module has finite Goldie dimension‎, ‎then it has Krull dimension if‎, ‎and only if‎, ‎it has essential Krull dimension and show that A/Soc(A) ‎‎has Krull dimension if‎, ‎and only if‎, ‎A has essential Krull dimension‎. ‎We introduce and study the concepts of non-summand Krull dimension of an R-module over an arbitrary associative ring R as a generalization of essential Krull dimension and small Krull dimension and we prove that an R-module has non-summand Krull dimension if‎, ‎and only if‎, ‎it has Krull dimension or is semisimple‎.
Arthroscopic treatment of bursal-sided rotator cuff tears using knotted and knotless single-suture bridge techniques: a retrospective cohort study
Authors: Hu Yangyang , Lu Yaojia , Wang Zhanye , Park Jin-Yong , fei Wen , Yang Yuxia , Zhang Yucheng , Gao Rangshan
Published: April 2023

Purpose To compare clinical outcomes of knotted and knotless single-suture bridge techniques in the arthroscopic treatment of bursal-sided rotator cuff tears.Methods Patients with bursal-sided tears were analyzed from June 2017 to March 2019; 54 patients were repaired using the knotted single-suture bridge technique (KT group), 59 patients with the knotless single-suture bridge technique (KLT group). All patients were followed up for a minimum of 24 months (in the range 24–35 months). The shoulder range of motion, and visual analog scale (VAS) score data were collected before operation, at three weeks, at three and six months after operation, and at the last follow-up. Meanwhile, American Shoulder and Elbow Surgeons (ASES) score and Constant–Murley (CS) shoulder score were collected before operation and at the last follow-up. Rotator cuff healing was evaluated by Barth ultrasonic classification at the last follow-up.Results At the last follow-up, VAS score had decreased from 5.0 (3.8, 6.0) to 0.0 (0.0, 1.0) in the KT group and from 5.0 (4.0, 6.0) to 0.0 (0.0, 0.0) in the KLT group. VAS score was higher in the KT group than in the KLT group at four postoperative time points. At three and six months after surgery, the patients in the KLT group had better anterior flexion and internal rotation than the KT group. Meanwhile, at the last follow-up, the internal rotation in the KLT group was still better than that of the KT group (P = 0.023), and the postoperative ASES score in the KLT group(97.90 ± 1.84) was significantly higher than that in the KT group(94.10 ± 3.18) (P = 0.001). Finally, there were two cases of retear in the KT group, and one case of retear in the KLT group, with no statistically significant difference (P = 0.938). At the final follow-up, healing was better in the KLT group by Barth ultrasonic classification (P = 0.019).Conclusions The knotless single-suture bridge technique maybe can result in more obvious pain relief, better anterior flexion and internal rotation range of motion, and functional recovery of the shoulder joint in the early stages. Also, healing may be better under ultrasound classification with the knotless single-suture bridge technique.Level of evidence: Level III; Retrospective Cohort Study; Treatment Study
On logarithmically superquadratic functions
Authors: Krnic Mario , Moradi Hamid Reza , Sababheh Mohammad
Published: April 2023

In this paper, we develop a concept of a logarithmically super\-qua\-dratic function. Such a class of functions is defined via superquadratic functions.These functions possess some superior properties, especially if they take values greater than or equal to one. We prove that they are convex and superadditive in the latter case.In particular, we also obtain the corresponding refinement of the Jensen inequality in a product form. Furthermore, we derive an external form of the Jenseninequality and the corresponding reverse. Finally, we give a variant of the Jensen operator inequality for logarithmically superquadratic functions.All established results are derived via the corresponding relations for superquadratic functions.
Hyperopic shift following corneal graft rejection in a patient with keratoconus: A case report
Authors: Cheng Ya-Feng , Liu Chun-Fu , Meir Yaa-Jyuhn James , Hsiao Ching-Hsi , Ma David Hui-Kang , Chen Hung-Chi
Published: April 2023

Background Penetrating keratoplasty (PK) is the dominant technique for visual restoration of corneal blindness worldwide. Corneal graft rejection and refractive errors are common postoperative issues of it, but correlation between these complications was seldom reported. To the author’s knowledge, this is the first reported case describing hyperopic change following post-penetrating keratoplasty graft rejection.Case presentation A 15-year-old female undergoing PK for advanced keratoconus in the left eye. Postoperatively, the graft was clear and her corrected distance visual acuity (CDVA) improved to 20/20. Corneal topography revealed anterior chamber depth (ACD) of 5.87 mm and keratometry readings of 42.4/46.1 diopters (D). However, decreasing visual acuity to counting fingers was noted after twelve months. Slit-lamp biomicroscopic examination showed stromal edema and mutton-fat keratic precipitates infiltration. Corneal graft rejection was diagnosed and CDVA resumed to 20/20 within one month after intensive topical and high-dose systemic steroid administration. Four years later, corneal topography revealed an ACD of 2.98 mm and keratometry readings of 42.4/45.1 D with spherical equivalence of + 1.25 D. Clinically and topographically, the corneal graft demonstrated a process of flattening before and after the episode of graft rejection.Conclusions Graft rejection may cause hyperopic shift in patients with keratoconus after PK.
Increased use of antidiabetic drugs does not necessarily increase blood sugar control for T2DM ： cross-sectional analysis from the rural-urban fringe zone of Suzhou city, Jiangsu Province
Authors: Han Xingfa , Xue Peng , Yang Jingyu , Wang Liping , Li Zheng , Wei Maoti , Ma Zhimin
Published: April 2023

Objective:
In order to control blood glucose levels, anti-glycemic drugs are used in T2DM patients. However, with more drugs are approved and widely clinical used, it is important to explore the association between the number of hypoglycemic drugs usage and T2DM control.
Methods:
From August 2018 to January 2021, three health service centers (urban-rural fringe zone) participated in T2DM health management project offering basic public health service from hospitals in Suzhou, Jiangsu province. Glycated hemoglobin (HbA1c) and fasting plasma glucose (FPG) level, combined with detail information of the diabetic history and hypoglycemic drugs usage were collected during the carryout of the project. Basic information and clinical laboratory examinations were analyzed with Student’ t or t’ or chi-square test for univariate analysis. Multivariate analyses were used for exploring multiple variables.
Results:
The level of glycosylated hemoglobin (HbA1c) less than 7.0% were consider as well-controlled of T2DM and the control rate of the patients was 36.8% (434 / 1179, 95% CI 33.2% - 38.8%). Sulfonylureas, biguanides, glucosidase inhibitors and insulin were the most frequently used hypoglycemic drugs in T2DM patients in this region and the utilization rates of them were 65.5%, 66.4%, 17.7% and 19.1% in the uncontrolled patients and in controlled were 68.4%, 58.5%, 14.3% and 11.1%, respectively. Higher proportion of biguanides, glycosidase inhibitors and insulin in the uncontrolled patients were observed than that in the controlled (P <0.05). The proportions for one, two, or more than three hypoglycemic drugs used in the uncontrolled patients were 29.5%, 51.7% and 18.8%, in the controlled group was 45.6%, 46.1% and 8.2%, respectively. On the whole, the number of drugs used in the uncontrolled patients was higher than that in the controlled group (P <0.001). Factors including the course of diabetes, biguanides, glucosidase inhibitors, and insulin usage were associated with poor glycemic control according to multivariate regression analysis.
Conclusions:
Anti-glycemic drugs play important role in lowering blood glucose for T2DM patients, but more drugs (more numbers or larger dosage ) might not improve blood glucose control. Especially, for management of diabetic patients in the rural-urban fringe zone, related factors should pay more attention other than hypoglycemic drugs.
Universal Chemical Programming Language for Robotic Synthesis Reproducibility
Authors: Hein Jason , Rauschen Robert , Guy Mason , Cronin Leroy
Published: April 2023

The amount of chemical synthesis literature is growing quickly, but it still takes a long time to share and evaluate new processes because of cultural and practical barriers. Herein, we present an approach that uses a universal chemical programming language (χDL) to encode and execute synthesis procedures for a variety of chemical reactions including reductive amination, ring formation, esterification, carbon-carbon bond formation, and amide coupling on different hardware and in different laboratories. With around fifty lines of code per reaction, our approach uses abstraction to efficiently compress chemical protocols. Our different robotic platforms consistently produce the expected synthesis with yields up to 90% per step, matching those achieved by an expert chemist. This allows for faster and more secure research workflows and can be used to increase the throughput of a process by number-up instead of scale-up. To achieve that we use Chemputer-type platforms at the University of Glasgow and the University of British Columbia, Vancouver as well as Opentrons- and multi-axis cobotic robots to distribute and reproduce experimental results. In total, protocols for 7 complex molecules were validated and disseminated to be reproduced in two international laboratories and on three independent robots.
Identification and validation of a prognostic risk score model for lung adenocarcinoma constructed based on immunogenic cell death
Authors: xie guijuan , Xu Yiming , Bao Liang , He Ting , Ren Xian , Ji JiaLi , Meng XinMin , Zhao Bo , Wang Xun
Published: April 2023

Background Immunogenic cell death (ICD) has been classified as a form of regulated cell death (RCD) sufficient to activate adaptive immune responses, which may contribute to the immunotherapy. The identification of ICD-related biomarkers stratifying lung adenocarcinoma patients according to their benefit from ICD immunotherapy would be of great advantage.Methods We identified two ICD-related subtypes by consensus clustering. Univariate and multivariate Cox proportional risk analyses were used to identify prognostic risk models with prognostic value. Kaplan-Meier analysis, univariate and multivariate Cox regression analysis, and subject work characteristic (ROC) curve analysis were used to validate the risk models.Results High ICD subtypes are associated with favorable clinical outcomes, abundant immune cell infiltration, and highly active immune response signaling. We developed and validated an ICD-related prognostic model that predicts survival of lung adenocarcinoma patients and correlates with the tumor immune microenvironment. In addition, predictive line graphs were created to further validate the risk model as a new independent prognostic factor for patients with lung adenocarcinoma.Conclusions we established a new classification system of LUAD based on ICD signatures. This stratification had significant clinical outcomes for estimating prognosis, as well as the immunotherapy of LUAD patients.
Combined Effects of Tropicamide Phenylephrine eyedrops on retinal microvasculature and choroidal thickness in myopic children
Authors: Zheng Min-Mig , Wang Tian-Tian , Dong Jing-hong , Li Chen-Hao , Cao Xiao , Wu Chang-Fan
Published: April 2023

Aims:To evaluate the effect of tropicamide phenylephrine(TP) eyedrops on the retinal and choroidal vascular density and choroidal thickness.
Methods: A prospective clinical study was used. 72 myopic children and adolescents aged 4-14 years old were given TP eyedrops to dilate the pupil, and all participants were given relevant ophthalmological examination before and after pupil dilation. OCTA is used to scan the macular 3*3mm area with layered lines. Image J software was used to measure the retinal and choroidal vascular density at each layer and OCT enhanced depth imaging mode was performed for the subfoveal choroidal thickness assessment.
Results: Following instillation of the TP eyedrops, the superficial retinal vascular density was decreased (from28.67±4.11 to 26.47±6.47, p<0.001) significantly, the choroidal vascular density increased (from37.04±6.83 to 37.81±6.20,p<0.001) in the macular area, and the choroidal thickness of subfoveal increased (from 243.94±65.10 to 248.59±69.11,p<0.001). Through multivariate analysis, age was the main factor that affects the superficial retinal and choroidal vascular density and choroidal thickness.
Conclusion: TP eyedrops can significantly reduce the superficial retinal vascular density and increase the choroidal vascular density and choroidal thickness in children. Age is the main factor that affects the superficial retinal and choroidal vascular density and choroidal thickness.
WITHDRAWN: Research on gas emission quantity prediction model based on EDA-IGA
Authors: Peng Ji , Shi shiliang , Shi Xingyu
Published: April 2023

In order to accurately predict the possible gas emission quantity in coal mines, it is proposed to use the multi-thread calculation of the Immune Genetic Algorithm (IGA) and injection of vaccines to improve the accuracy of prediction and combine the Estimation of Distribution Algorithm (EDA) to the distribution probability of excellent populations. Calculating, and selecting excellent populations for iteration, optimize the population generation process of the Immune Genetic Algorithm, so that the population quality is continuously optimized and improved, and the optimal solution is obtained, thereby establishing a gas emission quantity prediction model based on the Immune Genetic Algorithm and Estimation of Distribution Algorithm. Using the 9136 mining face with gas emission hazards in a coal mine from Shandong Province in China as the prediction object, the absolute gas emission quantity is used to scale the gas emission quantity, and it is found that the model can accurately predict the gas emission quantity, which is consistent with the on-site emission unanimous. In the prediction comparison with IGA, it is found that the accuracy of the prediction results has increased by 9.51%, and the number of iterations to achieve the required goal has been reduced by 67%, indicating that the EDA has a better role in optimizing the population update process such as genetic selection of the IGA. Comparing the prediction results of other models, it is found that the prediction accuracy of the EDA-IGA is 94.93%, which is the highest prediction accuracy, indicating that this prediction model can be used as a new method for the prediction of coal mine gas emission.
Magnetized metformin-functionalized carrageenan as a solid acid-base bifunctional nanocatalyst for the one-pot synthesis of dihydropyrano[2,3- c]pyrazoles
Authors: Heydari Forozan , Bakhtiarian Mohsen , Khodaei Mohammad Mehdi
Published: April 2023

In the current work we introduced a magnetic nanocatalyst with acidic-basic properties by coating Fe3O4 magnetic nanoparticles with kappa-carrageenan (Carr) and metformin (Met) moieties. The successful synthesis of Carr-Met-MNPs nanoparticles was verified by FT-IR, XRD, VSM, FESEM, EDX-mapping and TGA. The acidic-basic properties of Carr-Met-MNPs were studied by titration. The Carr-Met-MNPs nanoparticles demonstrated very good to excellent yields (88-94%) for the four-component domino synthesis of dihydropyrano [2, 3-c] pyrazoles via condensation of hydrazine hydrate, ethyl acetoacetate, malononitrile, and aromatic aldehydes in the aqueous ethanol as a benign solvent system. The synergistic effect of sulfonic acid and amino groups can justify the catalytic activity of Carr-Met-MNPs. Also, the catalyst can be magnetically recovered. Simplicity of catalyst synthesis, use of a benign solvent system, improved activity, and easy recoverability (up to 5 runs) is some of prominent advantages of the present catalyst system. The heterogeneity of Carr-Met-MNPs nanocomposites was also confirmed by a hot filtration test under optimum reaction conditions.
Synthesis, morphological, dielectric studies and ionic conductivity of a sodium cerium diphosphate compound
Authors: Hamrit Fareh , Chtourou Rabiaa , Taloub Djedid , Gharbi Imen , Oueslati Abderrazek
Published: April 2023

The NaCeP2O7 compound was successfully synthesized by a high-temperature reaction with the solid-state method. Analyzing the XRD pattern, of the studied compound, confirms the orthorhombic phase with the Pnma space group. The examination of SEM images reveals that the majority of grains are around 500 to 900 nm with a uniform distribution. As for the EDX analysis, all chemical elements were detected and found in their appropriate ratio. The curves of temperature-dependent imaginary modulus M" versus angular frequency reveal the presence of one peak at each temperature, proving that the dominant contribution is associated to the grains. The frequency dependence of the conductivity of alternating current is explained using Jonscher's law. The close values of the activation energies obtained from the jump frequency and extracted from the dielectric relaxation of the modulus spectra, as well from the continuous conductivity imply that the transport takes place by the Na+ ions hopping mechanism. The charge carrier concentration in the title compound has been evaluated and shown to be independent of temperature. The exponent s increases with the increase in temperature, this behavior proves that the non-overlapping small polaron tunneling (NSPT) is the appropriate conduction mechanism model.
Role of multiparametric magnetic resonance imaging and targeted biopsy in the detection of clinically significant prostate cancer in patients with abnormal digital rectal examination
Authors: Giannarini Gianluca , Ficarra Vincenzo , Rossanese Marta , Buttitta Alessandro , Alibrandi Angela , Anastasi Giuseppina , Blandino Alfredo , Ieni Antonio , Martini Maurizio
Published: April 2023

Background Few studies examined the role of prostate MRI in patients with abnormal digital rectal examination (DRE) and/or PSA > 10 ng/ml. In a cohort of non-screened patients with abnormal DRE, we investigated the rate of avoidable prostate biopsies and potentially missed clinically significant prostate cancer (csPCa) with negative MRI, and the concordance between targeted biopsy (TBx) and systematic biopsy (SBx) in detecting csPCa with positive MRI.Methods We retrospectively examined 199 biopsy-naïve patients with abnormal DRE who underwent prostate MRI before transperineal biopsy. Prostate Imaging - Reporting And Data System (PI-RADS) v2.1 ≥ 3 category of the index lesion defined a positive MRI. Combined TBx/SBx and SBX alone was performed for positive and negative MRI, respectively. An International Society of Urogenital Pathology Grade Group ≥2 defined csPCa. We calculated csPCa detection rate of TBx, SBx and combined TBx/SBx. The Cohen kappa statistic was used to measure the concordance between TBx and SBx.Results Ninety-one (45.7%) csPCa cases were detected. MRI was positive in 153 (76.9%) patients. In the 46 patients with negative MRI, SBx detected 5 (10.9%) csPCa cases. Prostate biopsy could, thus, be avoided in 41/199 (20.6%) patients at the cost of missing 5/91 (5.5%) csPCa cases. The concordance between TBx and SBx in detecting csPCa with positive mpMRI was substantial (k 0.70). Specifically, 6/86 (6.9%) csPCa cases were detected with TBx, and 17/86 (19.7%) with SBx alone. Concordance was almost perfect (k 0.82) in patients with PSA > 10 ng/ml. Only 4/38 (10.5%) csPCa cases were missed by TBx, and only 1 (2.6%) csPCa case was identified by TBx alone.Conclusion MRI in patients with abnormal DRE could avoid roughly 21% of unnecessary biopsies at the cost of missing approximately 6% of csPCa cases. Moreover, MRI and TBx complemented SBx in detecting csPCa in the subgroup with PSA > 10 ng/ml.