bluuebunny/crossref_metadata_2025 huggingface dataset:
Enhanced sensitivity of neutralizing antibody detection for different AAV serotypes using HeLa cells with overexpressed AAVR
Authors: Zheng Zhaoyue , Ye Jingya , Leng Mi , Gan Chunmei , Tang Na , Li Wei , Valencia C. Alexander , Dong Biao , Chow Hoi Yee
Published: April 2023

A cell-based transduction inhibition assay (TI) is widely used in clinical trials to detect neutralizing antibody (NAb) titers against recombinant adeno-associated virus (rAAV), one of the most important criteria to exclude patients in gene therapy. Different cell lines are used in cell-based TI because the rAAV transduction efficiencies vary largely among serotypes. A cell line suitable for TI for most serotypes is highly desirable, especially for those with very low transduction efficiencies in vitro such as rAAV8 and rAAV9. Herein, we report an AAVR-HeLa, a stable cell line with overexpressed AAVR, a newly identified receptor for rAAVs, was established for cell-based TIs. The AAVR expression level in AAVR-HeLa cells was approximately 10-fold higher than in HeLa cells, and was stably transfected after twenty three passages. For all AAV serotypes (AAV1-10), except for AAV4, the transduction efficiencies increased significantly in AAVR-HeLa cells. It was demonstrated that the AAVR enhancement of transduction efficiency was only for rAAV and not for lentiviral and adenoviral vectors. According to the minimal multiplicity of infection (MOIs) for the assay, the NAb detection sensitivity increased at least 10 and 20 fold for AAV8 and AAV9, respectively. The seroprevalence of NAbs were investigated at the 1:30 level as a cutoff value using AAVR-HeLa cells. It was shown that the seropositive rate for AAV2 was 87% in serum samples from 99 adults, followed by lower seropositive rates for AAV5 (7%), AAV8 (7%) and AAV9 (1%). Venn diagram analysis showed the presence of cross-reactivity of NAbs to two or three serotypes in 13 samples (13.1%). However, no patient was found to possess NAbs for all the four serotypes. These results demonstrated that the AAVR-HeLa cell line may be utilized to detect the NAbs through cell-based TI assays for most of AAV serotypes.
The Aboodh transformation-based homotopy perturbation method: new hope for fractional calculus
Authors: Tao Huiqiang , Anjum Naveed , Yang Yong-Ju
Published: April 2023

Fractional differential equations can model various complex problems in physics and engineering, but there is no universal method to solve fractional models precisely. This paper offers a new hope for this purpose by coupling the homotopy perturbation method with Aboodh transform. The new hybrid technique leads to a simple approach to finding an approximate solution, which converges fast to the exact one with less computing effort. An example of the fractional casting-mold system is given to elucidate the hope for fractional calculus, and this paper serves as a model for other fractional differential equations.
Doppler radar remote sensing of respiratory function
Authors: Ishrak Mohammad Shadman , Cai Fulin , Islam Shekh Md Mahmudul , Borić-Lubecke Olga , Wu Teresa , Lubecke Victor M.
Published: April 2023

Doppler radar remote sensing of torso kinematics can provide an indirect measure of cardiopulmonary function. Motion at the human body surface due to heart and lung activity has been successfully used to characterize such measures as respiratory rate and depth, obstructive sleep apnea, and even the identity of an individual subject. For a sedentary subject, Doppler radar can track the periodic motion of the portion of the body moving as a result of the respiratory cycle as distinct from other extraneous motions that may occur, to provide a spatial temporal displacement pattern that can be combined with a mathematical model to indirectly assess quantities such as tidal volume, and paradoxical breathing. Furthermore, it has been demonstrated that even healthy respiratory function results in distinct motion patterns between individuals that vary as a function of relative time and depth measures over the body surface during the inhalation/exhalation cycle. Potentially, the biomechanics that results in different measurements between individuals can be further exploited to recognize pathology related to lung ventilation heterogeneity and other respiratory diagnostics.
Analysis of pulmonary artery variation based on 3D reconstruction of CT angiography
Authors: Ma Xiaochao , Lu Tianyu , Qin Da , Cai Hongfei , Tang Ze , Yang Yue , Cui Youbin , Wang Rui
Published: April 2023

Objective: The aim of this study is to acquire pulmonary CT (Computed tomography) angiographic data for the purpose of creating a three-dimensional reconstruction. Additionally, we aim to analyze the features and deviations of the branches in both pulmonary lobes. This information is intended to serve as a more comprehensive and detailed reference for medical professionals when conducting preoperative evaluations and devising surgical plans.

Method: Between August 2019 and December 2021, 420 patients were selected from the thoracic surgery department at the First Hospital of Jilin University, and underwent pulmonary 64 channel contrast enhanced CT examinations (Philips ICT 256). The images were acquired at a 1.5 mm slice thickness, and the DCM files that complied with DICOM (Digital Imaging and Communications in Medicine) standards were analysed for 3D (three dimensional) reconstruction using Mimics 22.0 software. The reconstructed pulmonary artery models were assessed by attending chest surgeons and radiologists with over 10 years of clinical experience. The two-dimensional image planes, as well as the coronary and sagittal planes, were utilized to evaluate the arteries. The study analyzed the characteristics and variations of the branches and courses of pulmonary arteries in each lobe of the lungs, with the exception of the subsegmental arterial system. Two chest surgeons and two radiologists with professional titles-all of whom had over a decade of clinical experience-jointly evaluated the 3D models of the pulmonary artery and similarly assessed the characteristics and variations of the branches and courses in each lobe of the lungs.

Results: Significant variations were observed in the left superior pulmonary artery across the 420 subjects studied. In the left upper lobe, the blood supply of 4 arteries accounted for 50.5% (n = 212), while the blood supply of 2 arteries in the left lower lobe was the most common, accounting for 79.5% (n = 334). The greatest variation in the right pulmonary artery was observed in the branch supply of the right upper lobe mediastinal artery. In the majority of cases (77.9%), there were two arteries present, which was the most common configuration observed accounting for 64% (n = 269). In the right inferior lobe of the lung, there were typically 2–4 arteries, with 2 arteries being the most common configuration (observed in 79% of cases, n = 332).

Conclusion: The three-dimensional reconstruction of pulmonary artery CT angiography enables clear observation of the branches and distribution of the pulmonary artery while also highlighting any variations. This technique holds significant clinical value for preoperative assessments regarding lesions and blood vessels.
Defining a diverse core collection of the Colombian Central Collection of potatoes: a tool to advance research and breeding
Authors: Manrique-Carpintero Norma Constanza , Berdugo-Cely Jhon A. , Cerón-Souza Ivania , Lasso-Paredes Zahara , Reyes-Herrera Paula H. , Yockteng Roxana
Published: April 2023

The highly diverse Colombian Central Collection (CCC) of cultivated potatoes is the most important source of genetic variation for breeding and the agricultural development of this staple crop in Colombia. Potato is the primary source of income for more than 100.000 farming families in Colombia. However, biotic and abiotic challenges limit crop production. Furthermore, climate change, food security, and malnutrition constraints call for adaptive crop development to be urgently addressed. The clonal CCC of potatoes contains 1,255 accessions ― an extensive collection size that limits its optimal assessment and use. Our study evaluated different collection sizes from the whole clonal collection to define the best core collection that captures the total genetic diversity of this unique collection, to support a characterization more cost-effectively. Initially, we genotyped 1,141 accessions from the clonal collection and 20 breeding lines using 3,586 genome-wide polymorphic markers to study CCC’s genetic diversity. The analysis of molecular variance confirmed the CCC’s diversity with a significant population structure (Phi=0.359; p-value=0.001). Three main genetic pools were identified within this collection (CCC_Group_A, CCC_Group_B1, and CCC_Group_B2), and the commercial varieties were located across the pools. The ploidy level was the main driver of pool identification, followed by a robust representation of accessions from Phureja and Andigenum cultivar groups based on former taxonomic classifications. We also found divergent heterozygosity values within genetic groups, with greater diversity in genetic groups with tetraploids (CCC_Group_B1: 0.37, and CCC_Group_B2: 0.53) than in diploid accessions (CCC_Group_A: 0.14). We subsequently generated one mini-core collection size of 3 percent (39 entries) and three further core collections sizes of 10, 15, and 20 percent (i.e., 129, 194, and 258 entries, respectively) from the total samples genotyped. As our results indicated that genetic diversity was similar across the sampled core collection sizes compared to the main collection, we selected the smallest core collection size of 10 percent. We expect this 10 percent core collection to be an optimal tool for discovering and evaluating functional diversity in the genebank to advance potato breeding and agricultural-related studies. This study also lays the foundations for continued CCC curation by evaluating duplicity and admixing between accessions, completing the digitalization of data, and ploidy determination using chloroplast count.
Seed Bio-priming of wheat with a novel bacterial strain to modulate drought stress in Daegu, South Korea
Authors: Shaffique Shifa , Imran Muhammad , Kang Sang-Mo , Khan Muhammad Aaqil , Asaf Sajjad , Kim Won-Chan , Lee In-Jung
Published: April 2023

Wheat is one of the major cereal crop grown food worldwide and, therefore, plays has a key role in alleviating the global hunger crisis. The effects of drought stress can reduces crop yields by up to 50% globally. The use of drought-tolerant bacteria for biopriming can improve crop yields by countering the negative effects of drought stress on crop plants. Seed biopriming can reinforce the cellular defense responses to stresses via the stress memory mechanism, that its activates the antioxidant system and induces phytohormone production. In the present study, bacterial strains were isolated from rhizospheric soil taken from around the Artemisia plant at Pohang Beach, located near Daegu, in the South Korea Republic of Korea. Seventy-three isolates were screened for their growth-promoting attributes and biochemical characteristics. Among them, the bacterial strain SH-8 was selected preferred based on its plant growth-promoting bacterial traits, which are as follows: abscisic acid (ABA) concentration = 1.08 ± 0.05 ng/mL, phosphate-solubilizing index = 4.14 ± 0.30, and sucrose production = 0.61 ± 0.13 mg/mL. The novel strain SH-8 demonstrated high tolerance oxidative stress. The antioxidant analysis also showed that SH-8 contained significantly higher levels of catalase (CAT), superoxide dismutase (SOD), and ascorbic peroxidase (APX). The present study also quantified and determined the effects of biopriming wheat (Triticum aestivum) seeds with the novel strain SH-8. SH-8 was highly effective in enhancing the drought tolerance of bioprimed seeds; their drought tolerance and germination potential (GP) were increased by up to 20% and 60%, respectively, compared with those in the control group. The lowest level of impact caused by drought stress and the highest germination potential, seed vigor index (SVI), and germination energy (GE) (90%, 2160, and 80%, respectively), were recorded for seeds bioprimed with with SH-8. These results show that SH-8 enhances drought stress tolerance by up to 20%. Our study suggests that the novel rhizospheric bacterium SH-8 (gene accession number OM535901) is a valuable biostimulant that improves drought stress tolerance in wheat plants and has the potential to be used as a biofertilizer under drought conditions.
Virtual reality for the rehabilitation and prevention of intimate partner violence – From brain to behavior: A narrative review
Authors: Johnston Tania , Seinfeld Sofia , Gonzalez-Liencres Cristina , Barnes Nicolas , Slater Mel , Sanchez-Vives Maria V.
Published: April 2023

Rehabilitation and prevention strategies to reduce intimate partner violence (IPV) have limited effectiveness in terms of improving key risk factors and reducing occurrence. Accumulated experimental evidence demonstrates that virtual embodiment, which results in the illusion of owning a virtual body, has a large impact on people’s emotional, cognitive, and behavioral responses. This narrative review discusses work that has investigated how embodied perspective - taking in virtual reality has been used as a tool to reduce bias, to enhance recognition of the emotional state of another, and to reduce violent behaviors, in particular in the realm of IPV. Some of the potential neurological mechanisms behind these affective and behavioral changes are also discussed. The process of rehabilitation and prevention is complex and not always effective, but the integration of neuroscience-inspired and validated state-of-the-art technology into the rehabilitation process can make a positive contribution.
The electrophysiological characteristics of social exclusion: the perspective of close and distant relationships
Authors: Zhang Pengcheng , Zhu Min , Hu Jingjing , Gao Xiangping
Published: April 2023

The sources of social exclusion are very wide, ranging from the closest people to strangers. However, current studies mainly reveal the electrophysiological characteristics of social exclusion by means of binary comparison between social exclusion and social inclusion, and lack of in-depth analysis of the differences caused by different sources of exclusion. In this study, a static passing ball paradigm system including close and distant relationship identity information was used to reveal the electrophysiological characteristics of individuals when they were excluded by people with different close and distant relationships. The results showed that there was a degree effect of P2, P3a, and LPC components when individuals were excluded by people with different close and distant relationships. Specifically, the amplitude of P2, P3a, and LPC components was larger when individuals were excluded by more distant people. The results indicated that individuals would become more alert and perceive stronger exclusion experience when they were excluded by more distant people, which provided more diversified evidence for the conclusion that electrophysiological components were larger under the condition of exclusion, and revealed the electrophysiological basis behind the multiple motivation models. The results also helped to explain the physiological reasons behind individuals’ different coping behaviors toward excluder with different importance of relationship.
High quality implementation of 4Rs + MTP increases classroom emotional support and reduces absenteeism
Authors: Gómez John A. , Brown Joshua L. , Downer Jason T.
Published: April 2023

School-based social and emotional learning (SEL) programs are associated with improvements in children’s SEL and academic outcomes, and the quality of classroom interactions. The magnitude of these effects increases at high levels of program implementation quality. This study aimed to (1) identify teachers’ profiles of quality of implementation, (2) explore teachers and classroom characteristics contributing to their propensity to comply with high quality of implementation, and (3) examine the relations between school assignment to an SEL program, quality of classroom interactions, and child SEL and academic outcomes at different levels of teachers’ compliance propensity. This study drew upon data from a cluster-randomized controlled trial evaluating the efficacy of 4Rs + MTP, a literacy-based SEL program, on third and fourth grade teachers (n = 330) and their students (n = 5,081) across 60 New York City public elementary schools. Latent profile analysis indicated that measures of teacher responsiveness and amount of exposure to implementation supports contributed to the differentiation of profiles of high and low quality of implementation. Random forest analysis showed that more experienced teachers with low levels of professional burnout had high propensity to comply with high quality of implementation. Multilevel moderated mediation analysis indicated that 4Rs + MTP teachers with high compliance propensity were associated with higher classroom emotional support and lower children’s school absences than their counterparts in the control group. These findings may inform debates in policy research about the importance of providing the supports teachers need to implement SEL school programs with high quality.
Exploring cognitive, behavioral and autistic trait network topology in very preterm and term-born children
Authors: Leoni Marguerite , Vanes Lucy D. , Hadaya Laila , Kanel Dana , Dazzan Paola , Simonoff Emily , Counsell Serena J. , Happé Francesca , Edwards A. David , Nosarti Chiara
Published: April 2023

Introduction

Compared to full-term (FT) born peers, children who were born very preterm (VPT; <32 weeks’ gestation) are likely to display more cognitive and behavioral difficulties, including inattention, anxiety and socio-communication problems. In the published literature, such difficulties tend to be studied independently, thus failing to account for how different aspects of child development interact. The current study aimed to investigate children’s cognitive and behavioral outcomes as interconnected, dynamically related facets of development that influence one another.

Methods

Participants were 93 VPT and 55 FT children (median age 8.79 years). IQ was evaluated with the Wechsler Intelligence Scale for Children—4th edition (WISC-IV), autism spectrum condition (ASC) traits with the social responsiveness scale—2nd edition (SRS-2), behavioral and emotional problems with the strengths and difficulties questionnaire (SDQ), temperament with the temperament in middle childhood questionnaire (TMCQ) and executive function with the behavior rating inventory of executive functioning (BRIEF-2). Outcome measures were studied in VPT and FT children using Network Analysis, a method that graphically represents partial correlations between variables and yields information on each variable’s propensity to form a bridge between other variables.

Results

VPT and FT children exhibited marked topological differences. Bridges (i.e., the variables most connected to others) in the VPT group network were: conduct problems and difficulties with organizing and ordering their environment. In the FT group network, the most important bridges were: difficulties with initiating a task or activity and prosocial behaviors, and greater emotional problems, such as lower mood.

Discussion

These findings highlight the importance of targeting different aspects of development to support VPT and FT children in person-based interventions.
Relationship of Gaming Disorder with parenting based on low affection-communication and personality trait of neuroticism in adolescents
Authors: Rodríguez-Ruiz Francesc , Marí-Sanmillán María Isabel , Benito Ana , Castellano-García Francisca , Sánchez-Llorens Marta , Almodóvar-Fernández Isabel , Haro Gonzalo
Published: April 2023

Background

Gaming Disorder is increasingly common in adolescents. We aimed to evaluate the relationship between parenting, personality traits, and Gaming Disorder.

Methods

An observational and cross-sectional study in six secondary schools of Castelló, obtaining a final sample of 397 students.

Results

Adolescents with Gaming Disorder had lower scores in Adolescent Affection-Communication (F = 8.201; p < 0.001), Father’s Warmth (F = 3.459; p = 0.028), and Father’s Acceptance/Involvement (F = 5.467; p = 0.003), and higher scores in Mother’s Revoking Privileges (F = 4.277; p = 0.034) and Father’s Indifference (F = 7.868; p = 0.002) than healthy participants. Male sex was a risk factor for Gaming Disorder (OR = 12.221; p = 0.004), while Adolescent Affection-Communication (OR = 0.908; p = 0.001) and Agreeableness (OR = 0.903; p = 0.022) were protective factors. Data modeling described the protective effect that Adolescent Affection-Communication had on Gaming Disorder, which was both directly (B = -0.20; p < 0.001) and indirectly mediated by Neuroticism (B = -0.20; p < 0.001), while Neuroticism itself was a risk factor for Gaming Disorder (B = 0.50; p < 0.001).

Conclusion

These results reflect that Parental style with low affection and communication was directly and indirectly related to the Gaming Disorder, as well as male sex and personality trait of Neuroticism.
Rëâdīńg wõrdš wîth ōrńåmêńtš: is there a cost?
Authors: Duñabeitia Jon Andoni , Perea Manuel , Labusch Melanie
Published: April 2023

Introduction

Recent research has reported that adding non-existent diacritical marks to a word produces a minimal reading cost compared to the intact word. Here we examined whether this minimal reading cost is due to: (1) the resilience of letter detectors to the perceptual noise (i.e., the cost should be small and comparable for words and nonwords) or (2) top-down lexical processes that normalize the percept for words (i.e., the cost would be larger for nonwords).

Methods

We designed a letter detection experiment in which a target stimulus (either a word or a nonword) was presented intact or with extra non-existent diacritics [e.g., amigo (friend) vs. ãmîgô; agimo vs. ãgîmô]. Participants had to decide which of two letters was in the stimulus (e.g., A vs. U).

Results

Although the task involved lexical processing, with responses being faster and more accurate for words compared to nonwords, we found only a minimal advantage in error rates for intact stimuli versus those with non-existent diacritics. This advantage was similar for both words and nonwords.

Discussion

The letter detectors in the word recognition system appear to be resilient to non-existent diacritics without the need for feedback from higher levels of processing.
The therapeutic use and efficacy of ketamine in alcohol use disorder and alcohol withdrawal syndrome: a scoping review
Authors: Goldfine Charlotte E. , Tom Jeremiah J. , Im Dana D. , Yudkoff Benjamin , Anand Amit , Taylor Joseph J. , Chai Peter R. , Suzuki Joji
Published: April 2023

Introduction

Alcohol use disorder (AUD) is the most prevalent substance use disorder (SUD) globally. In 2019, AUD affected 14.5 million Americans and contributed to 95,000 deaths, with an annual cost exceeding 250 billion dollars. Current treatment options for AUD have moderate therapeutic effects and high relapse rates. Recent investigations have demonstrated the potential efficacy of intravenous ketamine infusions to increase alcohol abstinence and may be a safe adjunct to the existing alcohol withdrawal syndrome (AWS) management strategies.

Methods

We followed Preferred Reporting Items for Systematic Reviews (PRISMA) guidelines to conduct a scoping review of two databases (PubMed and Google Scholar) for peer-reviewed manuscripts describing the use of ketamine in AUD and AWS. Studies that evaluated the use of ketamine in AUD and AWS in humans were included. We excluded studies that examined laboratory animals, described alternative uses of ketamine, or discussed other treatments of AUD and AWS.

Results

We identified 204 research studies in our database search. Of these, 10 articles demonstrated the use of ketamine in AUD or AWS in humans. Seven studies investigated the use of ketamine in AUD and three studies described its use in AWS. Ketamine used in AUD was beneficial in reducing cravings, alcohol consumption and longer abstinence rates when compared to treatment as usual. In AWS, ketamine was used as an adjunct to standard benzodiazepine therapy during severe refractory AWS and at signs of delirium tremens. Adjunctive use of ketamine demonstrated earlier resolution of delirium tremens and AWS, reduced ICU stay, and lowered likelihood of intubation. Oversedation, headache, hypertension, and euphoria were the documented adverse effects after ketamine administration for AUD and AWS.

Conclusion

The use of sub-dissociative doses of ketamine for the treatment of AUD and AWS is promising but more definitive evidence of its efficacy and safety is required before recommending it for broader clinical use.
Toward therapeutic drug monitoring of citalopram in depression? Insights from a systematic review
Authors: Xu Na , Song Zaiwei , Jiang Dan , Zhao Rongsheng
Published: April 2023

Background

Within the framework of individualized psychopharmacotherapy, therapeutic drug monitoring (TDM) has gained increasing relevance. In the absence of high-quality evidence, the TDM of citalopram (CIT) and the recommended therapeutic ranges of the plasma concentrations have been proposed by guidelines. However, the correlation between the plasma concentration of CIT and treatment outcomes has not been well established. Therefore, the aim of this systematic review was to evaluate the relationship between plasma CIT concentration and treatment outcomes in depression.

Research design and methods

PubMed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and Chinese databases (CNKI, Wanfang Data and Sinomed) were searched up to August 6, 2022. We included clinical studies evaluating the correlation between the plasma CIT concentration and treatment outcomes in patients with depression receiving CIT treatment. Outcomes measured included efficacy, safety, medication adherence, and cost-related outcomes. A narrative synthesis was performed to summarize findings from individual studies. This study was performed according to the Preferred Reporting Items for Systematic Reviews, Meta-Analysis (PRISMA) and the reporting guideline for Synthesis without meta-analysis (SWiM).

Results

Eleven studies involving 538 patients were included in total. The reported outcomes were mainly efficacy (n = 11) and safety (n = 3); one study reported the duration of hospitalization, and no study reported medication adherence. Regarding the efficacy outcomes, three studies revealed the plasma CIT concentration-response relationship and proposed a lower limit of 50 or 53 ng/mL, whereas this was not found in the rest of the studies. Regarding adverse drug events (ADEs), one study reported more ADEs in the low-concentration group (<50 ng/mL vs. >50 ng/mL), which is not convincing from the perspective of pharmacokinetics/pharmacodynamics. Regarding the cost-related outcomes, only one study reported that the high CIT concentration group (≥50 ng/mL) contributed to shortening the hospitalization duration, but it did not provide detailed information, including direct medical expenses and multiple potential factors contributing to longer hospital stays.

Conclusions

A definite correlation between plasma concentration and clinical or cost-related outcomes of CIT cannot be drawn, whereas a tendency toward improved efficacy in patients with plasma concentration above 50 or 53 ng/mL was suggestive from limited evidence.
Psychometric properties of the mock interview rating scale for schizophrenia and other serious mental illnesses
Authors: Smith Matthew J. , Burke-Miller Jane K. , Bornheimer Lindsay A. , Ross Brittany , Bell Morris D. , McGurk Susan R. , Mueser Kim T. , Brown Adrienne , Prestipino John , Borghani Nayab , Nelson Karley , Lieberman Tovah , Pashka Nicole J. , Razzano Lisa A. , Kallen Michael A.
Published: April 2023

Background

Over the past 10 years, job interview training has emerged as an area of study among adults with schizophrenia and other serious mental illnesses who face significant challenges when navigating job interviews. The field of mental health services research has limited access to assessments of job interview skills with rigorously evaluated psychometric properties.

Objective

We sought to evaluate the initial psychometric properties of a measure assessing job interview skills via role-play performance.

Methods

As part of a randomized controlled trial, 90 adults with schizophrenia or other serious mental illnesses completed a job interview role-play assessment with eight items (and scored using anchors) called the mock interview rating scale (MIRS). A classical test theory analysis was conducted including confirmatory factor analyses, Rasch model analysis and calibration, and differential item functioning; along with inter-rater, internal consistency, and test-retest reliabilities. Pearson correlations were used to evaluate construct, convergent, divergent, criterion, and predictive validity by correlating the MIRS with demographic, clinical, cognitive, work history measures, and employment outcomes.

Results

Our analyses resulted in the removal of a single item (sounding honest) and yielded a unidimensional total score measurement with support for its inter-rater reliability, internal consistency, and test-retest reliability. There was initial support for the construct, convergent, criterion, and predictive validities of the MIRS, as it correlated with measures of social competence, neurocognition, valuing job interview training, and employment outcomes. Meanwhile, the lack of correlations with race, physical health, and substance abuse lent support for divergent validity.

Conclusion

This study presents initial evidence that the seven-item version of the MIRS has acceptable psychometric properties supporting its use to assess job interview skills reliably and validly among adults with schizophrenia and other serious mental illnesses.

Clinical Trial Registration

NCT03049813.
Association of fear of COVID-19 and resilience with psychological distress among health care workers in hospitals responding to COVID-19: analysis of a cross-sectional study
Authors: Midorikawa Haruhiko , Tachikawa Hirokazu , Kushibiki Natsuho , Wataya Keiko , Takahashi Sho , Shiratori Yuki , Nemoto Kiyotaka , Sasahara Shinichiro , Doki Shotaro , Hori Daisuke , Matsuzaki Ichiyo , Arai Testuaki , Yamagata Kunihiro
Published: April 2023

Background

It remains unclear how fear of COVID-19 and resilience are related to psychological distress based on occupations among healthcare workers (HCWs) in hospitals treating patients with COVID-19. We conducted a survey on the mental health of HCWs during the COVID-19 pandemic to determine the relationship between factors such as fear of COVID-19 and resilience as well as mental distress in each occupation of HCWs.

Methods

We conducted a web-based survey among HCWs at seven hospitals treating COVID-19 patients in Japan from December 24, 2020 to March 31, 2021. A total of 634 participants were analyzed, and information regarding their socio-demographic characteristics and employment status was collected. Several psychometric measures were used, including the Kessler’s Psychological Distress Scale (K6), the fear of COVID-19 Scale (FCV-19S), and the Resilience Scale (RS14). Factors related to psychological distress were identified by logistic regression analysis. The association between job title and psychological scales was examined by one-way ANOVA, and t-tests were conducted to examine the association between the FCV-19S and hospital initiatives.

Results

It was found that nurses and clerical workers were associated with psychological distress without considering FCV-19S or RS14; in a model that included FCV-19S, FCV-19S was associated with psychological distress, but job title was not; when RS14 was considered, resilience was protective. In terms of occupation, FCV-19S was lower among physicians and higher among nurses and clerical workers, while RS14 was higher among physicians and lower among other occupations. Having access to in-hospital consultation regarding infection control as well as to psychological and emotional support was associated with lower FCV-19S.

Conclusion

Based on our findings, we can conclude that the level of mental distress differed by occupation and the differences in the fear of COVID-19 and resilience were important factors. In order to provide mental healthcare for HCWs during a pandemic, it is important to create consultation services that enable employees to discuss their concerns. In addition, it is important to take steps to strengthen the resilience of HCWs in preparation for future disasters.
Anxiety, depressive symptoms, and distress over the course of the war in Ukraine in three federal states in Germany
Authors: Massag Janka , Diexer Sophie , Klee Bianca , Costa Daniela , Gottschick Cornelia , Broda Anja , Purschke Oliver , Opel Nils , Binder Mascha , Sedding Daniel , Frese Thomas , Girndt Matthias , Hoell Jessica , Moor Irene , Rosendahl Jonas , Gekle Michael , Mikolajczyk Rafael
Published: April 2023

Introduction

The Russian invasion of Ukraine and the resulting consequences are in the center of political discussions, media, and likely individual thinking of the population in Germany. Yet, the impact of this prolonged exposure on mental health is not known hitherto.

Methods

Using the population based cohort study DigiHero from three federal states (Saxony-Anhalt, Saxony, and Bavaria), we assessed anxiety levels (GAD-7), depressive symptoms (PHQ-9), and distress (modified PDI) in the first weeks of war and 6 months later.

Results

Of those 19,432, who responded in the first weeks of war, 13,934 (71.1%) responded also 6 months later. While anxiety and emotional distress decreased during the 6 months, their average scores were still elevated, and a substantial fraction of respondents displayed clinically relevant sequelae. Persons from low-income households were especially affected, specifically by fears related to the personal financial situation. Those who reacted with a particularly strong fear in the beginning of war were more likely to have persistent clinically relevant symptoms of depression and anxiety also 6 months later.

Discussion

The Russian invasion of Ukraine is accompanied by continuing impairment of mental health in the German population. Fears surrounding the personal financial situation are a strong determinant.
Longitudinal associations between different types of screen use and depression and anxiety symptoms in adolescents
Authors: Mougharbel Fatima , Chaput Jean-Philippe , Sampasa-Kanyinga Hugues , Colman Ian , Leatherdale Scott T. , Patte Karen A. , Goldfield Gary S.
Published: April 2023

Background

Evidence examining the longitudinal associations between different types of screen behaviours and mental health among adolescents is limited. The present study examined the association between five types of screen behaviours and symptoms of anxiety and depression one year later. This study also assessed how changes in screen time were associated with changes in anxiety and depressive symptoms and whether the observed relationships were moderated by sex.

Methods

Longitudinal data of 17,174 students in grades 9–12 (53.5% females; mean age: 15.1 ± 0.9 years) attending high schools in Canada from two waves (year 6: 2017/18, year 7: 2018/19) of the COMPASS study were analyzed. Leisure screen time and mental health measures were self-reported. To test if the associations between screen time and anxiety, and depression vary by sex, two-way interactions were examined for sex. Analyses accounted for school clustering, race/ethnicity, sex, age, income, body mass index z-score, and previous year anxiety and depression symptoms.

Results

There were significant longitudinal associations between time spent on each type of screen and subsequent anxiety and depression symptoms. The strength of the associations varied by type of screen behaviour. Interaction analysis indicated a sex difference for television viewing and anxiety and depression symptoms, and internet surfing and anxiety symptoms. A dose-response relationship was observed between phone talking and anxiety symptoms. Beta estimates indicated that an increase in screen duration was associated with a further increase in anxiety and depression symptoms.

Conclusion

Higher screen time was longitudinally associated with higher anxiety and depression symptoms at one-year follow-up in adolescents. Time-change associations between screen usage and depressive and anxiety symptoms were observed. Also, associations differed based on sex and screen type, whereby greater increases in screen use predicted greater emotional distress. Findings from this prospective analysis suggest that screen time is an important determinant of anxiety and depressive symptoms among adolescents. Future studies are recommended to help inform programs promoting screen time reduction with a goal to enhance adolescents’ mental health.
Relationships between antibiotic exposure and asthma in adults in the United States: results of the National Health and Nutrition Examination Survey between 1999 and 2018
Authors: Li Shaoli , Chen Feilong , Huang Chunlei , Huang Guimin , Cheng Yijing , Li Tao , Hou Dongqing , Liu Wenqian , Xu Tao , Liu Junting
Published: April 2023

Objectives

To investigate the relationship between antibiotic exposure and asthma in adults in the United States.

Methods

Data was obtained from the National Health and Nutrition Examination Survey (NHANES) conducted between 1999 and 2018. A total of 51,124 participants were included, excluding those who were aged < 20 years, female participants who were pregnant, and individuals who did not complete the prescription medications questionnaire and the medical conditions questionnaire regarding asthma status. Antibiotic exposure was defined as the utilization of antibiotics within the past 30 days, categorized based on the Multum Lexicon Plus therapeutic classification system. Asthma was defined as having a history of asthma or having an asthma attack or wheezing symptoms in the past year.

Results

The risk of asthma was found to be 2.557 (95% CI: 1.811, 3.612), 1.547 (95% CI: 1.190, 2.011) and 2.053 (95% CI: 1.344, 3.137) times greater in participants who had used macrolide derivatives, penicillin and quinolones in the past 30 days, respectively, compared with those not using antibiotics. After adjusting for demographic covariates and asthma-related factors, only macrolides derivatives were significantly associated with asthma in the 20–40 and 40–60 age groups. For individuals over 60 years old, quinolones were significantly associated with asthma. The effect of different types of antibiotic with asthma varied in male and female populations. Moreover, higher socioeconomic status, greater BMI, younger age, smoking habits, history of infection, chronic bronchitis, emphysema, and family history of asthma were all identified as risk factors for asthma.

Conclusion

Our study indicated that three types of antibiotics were significantly associated with asthma in different subgroups of the population. Therefore, the use of antibiotics should be more strictly regulated.
Regular consumption of pickled vegetables and fermented bean curd reduces the risk of diabetes: a prospective cohort study
Authors: Cai Yulan , Yang Xiaoxia , Chen Siju , Tian Kunming , Xu Suowen , Deng Renli , Chen Min , Yang Yan , Liu Tao
Published: April 2023

Objective

The global incidence of diabetes is rising, in part due to the widespread adoption of poor dietary habits. Fermented vegetables have numerous health benefits and are generally affordable. Here, we examined whether regular consumption of pickled vegetables or fermented bean curd reduces the risk of diabetes.

Methods

A total of 9,280 adults (≥18 years of age) were recruited via multi-stage sampling from 48 townships in China between 2010 and 2012 for this 10-year prospective study. In addition to demographic information, monthly consumption levels of pickled vegetables and fermented bean curd were recorded. Participants were then monitored for diabetes onset. After the final follow-up, logistic regression analyses with multiple covariant corrections were conducted to estimate the changes in diabetes risk associated with consumption of pickled vegetables and fermented bean curd compared to non-consumption.

Results

A total of 6,640 subjects without diabetes at the start of the study were followed up for a median period of 6.49 years, among whom 714 were diagnosed with diabetes during the study. According to a regression model with multivariable adjustment, diabetes risk was significantly reduced by consumption of 0–0.5 kg/month of pickled vegetables (OR = 0.77, 95% CI: 0.63, 0.94) and further reduced by consumption of >0.5 kg/month of pickled vegetables (OR = 0.37, 95% CI: 0.23, 0.60) compared to no consumption (both P-trend < 0.001). Consumption of fermented bean curd also reduced diabetes risk (OR = 0.68, 95% CI: 0.55, 0.84).

Conclusion

Regular consumption of pickled vegetables and/or fermented bean curd can reduce the long-term risk of diabetes.
The Institute of Medicine’s call to action revisited: assuring access to public health education for U.S. college students
Authors: Caron Rosemary M. , Aytur Semra , Foster Haylee
Published: April 2023

The Educated Citizen and Public Health initiative promotes that an understanding of public health issues is a principal component of an educated population and is necessary to develop social responsibility and promote civic dialog. This initiative supports the Institute of Medicine’s (now the National Academy of Medicine) recommendation that “all undergraduates should have access to education in public health.” The purpose of our work is to examine the extent to which 2- and 4-year U.S. state colleges and universities offer and/or require a public health course. Select indicators identified include the presence and type of public health curriculum, public health course requirement, presence of public health graduate program offering, pathways to public health, Community Health Worker training, as well as demographic information for each institution. An analysis was also conducted for the historically Black colleges and universities (HBCUs), and the same select indicators were examined. The data suggest that there is an imperative need for a public health curriculum across the nation’s collegiate institutions with 26% of 4-year state institutions lacking a full undergraduate public health curriculum; 54% of 2-year colleges not offering a pathway to public health education; and 74% of HBCUs not offering a public health course or degree. In the age of COVID-19, syndemics, and considering the post-pandemic phase, we argue that expanding public health literacy at the associate and baccalaureate level can help prepare an educated citizenry who is both public health literate and one that can demonstrate resilience in the face of public health challenges.
The pysat ecosystem
Authors: Stoneback R. A. , Burrell A. G. , Klenzing J. , Smith J.
Published: April 2023

The Python Satellite Data Analysis Toolkit (pysat) is an open source package that implements a general data analysis workflow for arbitrary data sets, providing a consistent manner for obtaining, managing, analysing, and processing data, including modelled and observational ground and space-based data sets for the space sciences. Pysat enables systematic and individual treatment of data as well as simplifies rigorous data access and use, allowing larger-scale scientific efforts including machine learning, data assimilation, and constellation instrumentation processing. Since the start of its development pysat has evolved into an ecosystem, separating general file and data handling functionality from both individual data set support and generalized data analysis. This design choice ensures that the core pysat package has only the necessary functionality required to provide data management services for the wider development community. The shift of data and analysis support to ecosystem packages makes it easier for the community to contribute to, as well as use, the full array of features and data sources enabled by pysat. Pysat’s ease of use, and generality, supports adoption outside of professional science to include industry, citizen science, and education.
Unsolved problems: Mesoscale polar cap flow channels’ structure, propagation, and effects on space weather disturbances
Authors: Lyons Larry R. , Nishimura Yukitoshi , Liu Jiang , Zou Ying , Bristow William A. , Yadav Sneha , Donovan Eric , Nishitani Nozomu , Shiokawa Kazuo , Hosokawa Keisuke
Published: April 2023

Dynamic mesoscale flow structures move across the open field line regions of the polar caps and then enter the nightside plasma sheet where they can cause important space weather disturbances, such as streamers, substorms, and omega bands. The polar cap structures have long durations (apparently at least ∼1½ to 2 h), but their connections to disturbances have received little attention. Hence, it will be important to uncover what causes these flow enhancement channels, how they map to the magnetospheric and magnetosheath structures, and what controls their propagation across the polar cap and their dynamic effects after reaching the nightside auroral oval. The examples presented here use 630-nm auroral and radar observations and indicate that the motion of flow channels could be critical for determining when and where a particular disturbance within the nightside auroral oval will be triggered, and this could be included for full understanding of flow channel connections to disturbances. Also, it is important to determine how polar cap flow channels lead to flow channels within the auroral oval, i.e., the plasma sheet, and determine the conditions along nightside oval/plasma sheet field lines that interact with an incoming polar cap flow channel to cause a particular disturbance. It will also be interesting to consider the generality of geomagnetic disturbances being related to connections with incoming polar cap flow channels, including the location, time, and type of disturbances, and whether the duration and expansion of disturbances are related to flow channel duration and to multiple flow channels.