bluuebunny/crossref_metadata_2025 huggingface dataset:
O PENSAMENTO EDUCACIONAL DE JOHANN FRIEDRICH HERBART (1776-1841)
Authors: Oliveira Camila Rezende , De Oliveira Guilherme Saramago , Santos Anderson Oramisio , Faria Borges Tatiane Daby de Fatima Faria Borges de Fatima
Published: May 2024

Este artigo apresenta e analisa algumas das contribuições teóricas do pensamento de Johann Friedrich Herbart para a educação atual. Johann Friedrich Herbart pode ser identificado como percursor de Johann Heinrich Pestalozzi e Friedrich Fröbel e o seu pensamento tem como foco principal a instrução educativa unindo seus postulados filosóficos com a pedagogia elaborada por ele mesmo. Sobre os estudos de Herbart recai a relevância de uma Pedagogia científica, de uma a reforma educacional crítica e mais a unidade social como ponto de partida para a melhoria dos processos harmônicos entre os sujeitos viventes. A discussão foi realizada com base em uma pesquisa de cunho bibliográfica em artigos e livros acadêmicos digitais que tratassem à respeito do assunto anteriormente evidenciado. Esse ensaio textual retoma os pensamentos de Herbart e traz apontamentos de sua teoria para o cenário educacional da atualidade. Foi possível a constatação que os estudos apresentados por Johann Friedrich Herbart tiveram como foco a Pedagogia Tradicional, porém suas concepções foram de extrema relevância para o cenário educacional. Sua obra e seus afazeres práticos ganham sentido em contexto exploratório de homens que viveram como vassalos e nobres. Além das contribuições pedagógicas Herbart retrata as questões da Psicologia possibilitando respostas para a transformação social. Teórico das concepções de estudos profundos, Herbart evidencia a intelectualidade do seu tempo e reforça o debate acadêmico à respeito do autogoverno  e da Pedagogia como campo independente de estudo.
REDUÇÃO DE INVESTIMENTOS EM GESTÃO AMBIENTAL: IMPACTO EM UM INDICADOR ESTRATÉGICO DE UMA EMPRESA DO SETOR ENERGÉTICO
Authors: Guimarães Alberto Márcio Teixeira , Cribb André Yves
Published: May 2024

A adoção e manutenção de um Sistema de Gestão Ambiental pode ser considerado diferencial competitivo, devido ao fato de tais ações possuírem potencial para causar melhoria na imagem, credibilidade junto aos órgãos reguladores e melhoria contínua nos processos das organizações. A monitoração dos resultados e objetivos de um SGA, conforme a ISO 14001, ocorre através de indicadores ambientais. Apesar das vantagens da adoção de um SGA, o fator investimento ainda é um tabu em diversas empresas quando se trata de meio ambiente. Por vezes, a área ambiental é uma das primeiras a sofrer corte de recursos e investimentos quando há necessidade de economizar. Norteia-se esse estudo através da questão: a redução de investimentos ambientais impacta o atendimento aos objetivos ambientais das organizações? Foi objeto do estudo uma empresa do setor energético, cuja uma das condicionantes de licença de operação é executar um Programa de Recuperação de Áreas Degradadas, que possui dentre seus indicadores, o IMP (Indicador de Mudas Plantadas). O objetivo do trabalho é verificar se as subsequentes reduções de investimento no PRAD impactaram nos resultados do IMP no período entre 2015 e 2020. Para isso, foi utilizada a abordagem quantitativa, através da aplicação do teste t-de-Student, de modo a testar a hipótese supramencionada. A partir do resultado, foi possível verificar que a redução de investimento no PRAD causou impacto nos resultados dos indicadores. Conclui-se que o impacto causado pela diminuição dos investimentos pode atingir o SGA, de modo a exigir adequações em diversos aspectos de gestão ambiental da empresa.
As coleções botânicas como material didático para o processo de ensino-aprendizagem no ensino médio
Authors: Alves Leonardo Carvalho , Lima Renato Abreu
Published: May 2024

Nos últimos anos houve um relevante crescimento de práticas didático-pedagógicas em relação à abordagem de conteúdos em Botânica na disciplina de Biologia, especialmente no ensino básico. Com base nisso, este trabalho teve como objetivo estimular o interesse de alunos em relação à criação de técnicas de coleções botânicas. O trabalho foi desenvolvido em uma escola pública estadual com a participação de quatro turmas da 3ª série de Ensino Médio, constituindo-se de 105 alunos. Posterior à abordagem de assunto em sala de aula e socialização de informações sobre coleções botânicas a partir de oficinas, formaram-se grupos, onde estes confeccionaram a xiloteca, sementeca, exsicatas e coleções florais em meio líquido. Os resultados apontam que há uma deficiência de conhecimentos básicos em Botânica que poderiam ser trabalhados na disciplina de Biologia, nesse caso se fortalece a ideia de que o ensino-aprendizagem deve ser mútuo entre o professor e o estudante. Por outro lado, a utilização de oficinas ativas realizadas nesta pesquisa, possibilitaram-se ações teórico-práticas para o ensino de Botânica por meio de materiais didáticos alternativos, os quais, de acordo com os resultados obtidos, facilitaram a compreensão do conteúdo proposto, demostrando-se eficiente no processo de desenvolvimento e edificação do conhecimento dos estudantes. Portanto, com a construção das coleções botânicas, os estudantes se aproximaram dos assuntos que envolvem essa Ciência por meio de material construído em sala de aula, demostrando aos mesmos que é possível ensinar e aprender de maneira didática e dinâmica os assuntos teorizados e considerados engessados.
O TEMA “ORIGEM DA VIDA” EM LIVROS DIDÁTICOS DE CIÊNCIAS DO BRASIL E DE PORTUGAL
Authors: Souza Maíra Luana Santos , Maricato Fúlvia Eloá , Magalhães Júnior Carlos Alberto de Oliveira , Carvalho Graça Simões
Published: May 2024

Considerando a diversidade de explicações de natureza científica, filosófica e religiosa envolvida na abordagem do tema Origem da Vida, o objetivo da presente pesquisa foi analisar como este  tema é abordado nas coleções mais adotadas de Livros Didáticos do Brasil e de Portugal do componente curricular de Ciências para o 6º, 7º, 8º e 9º ano de ensino. Nesta pesquisa qualitativa, empregou-se para a sistematização, codificação e categorização dos dados a Análise de Conteúdo. Além disso, utilizou-se dos aportes teóricos da Teoria da Transposição Didática e dos referencias históricos, filosóficos e teóricos de áreas específicas da Ciência utilizadas no levantamento bibliográfico sobre o tema. Os resultados encontrados mostram que a abordagem do tema não se restringe apenas ao ano de ensino sugerido pelos documentos oficiais da educação do Brasil e de Portugal e ainda, não preconiza apenas as explicações científicas mais aceitas na atualidade pela comunidade científica. No entanto, a variedade e o modo como as explicações são abordadas nos livros dos dois países divergem, sugerindo diferentes relações desses países com as fontes de referência científicas nas quais residem os conhecimentos do currículo. Observou-se também, para ambos os países, a descontextualização, a redução dos experimentos e suas hipóteses abordadas com os seus contextos de produção, além de isolamentos do tema com conceitos intimamente relacionados, preocupando sobre o impacto dos mesmos no ensino-aprendizagem do tema, se considerarmos que os Livros Didáticos de Ciências são, além de fonte de planejamento de aulas, apoio às atividades de ensino-aprendizagem e ainda, fonte de estudos para professores e estudantes. A presente pesquisa contribui com reflexões sobre o Ensino de Ciências e indica a necessidade de mais investigações sobre o ensino do tema Origem da Vida.
MODELING VERTICAL MOBILITY OF P IN REGOSOLS OF THE BRAZILIAN SEMIARID REGION: LEACH COLUMN EXPERIMENT
Authors: Alves Carneiro Kalline de Almeida , Fraga Vânia da Silva , Correa Marcus Metri , Dantas Antonino Antônio Celso , Da Silva Lívia Previatello , Moro Letícia , Salgueiro Gondim Manuella Virginia , Dias Bruno de Oliveira , Vargas de Mello Jaime Wilson , Macedo Rodrigo Santana , Vendruscolo Jhony
Published: May 2024

Phosphorus (P) mobility can be high in sandy soils in tropical regions due to its high proportion of macropores, low levels of Fe and/or Al oxides, and low natural levels of organic matter. The aim of this study was to verify if the fit with convection-dispersion model (CDE) is adequate to analyze P vertical mobility in Regosols from the Brazilian semiarid region. Leaching columns were packed with two soils, fertilized with cattle manure. The columns were prepared based on the hydrodispersive parameters of the modeling with potassium bromide (KBr) and saturated flow. Soil samples were saturated with calcium chloride (CaCl2) and potassium chloride (KCl), both 0.001 mol L-1, and a pulse of 0.6 mmol L-1 of P. The hydrodispersive parameters (inverse method) were estimated using the CDE (CXTFIT). The soil samples packed in the columns, the delay factors (R) were around 1, the dispersivity values (λ) were very close, and the Péclet numbers (Pe) were greater than 10. In the P pulse transport assay, Pleached contents were on average 270.8 mg L-1, and it was observed that most of Pleached were translocated with 20 Vp, from 40 Vp the relationship between concentration and volume remains constant; hydrodynamic dispersion coefficients (D) ranged from 22.85 to 72.50 cm2 h-1, R ranged from 2.36 to 5.23, Damkohler number (ω) values were less than 1, and Pe ranged from 0.76 to 2.40. The adjustment with the CDE was efficient to demonstrate the vertical mobility of P in Regosols of the Brazilian semiarid region.
DESAFIOS E POSSIBILIDADES DO USO DOS RECURSOS TECNOLÓGICOS PARA O PROCESSO DE ENSINO E APRENDIZAGEM: um olhar a partir do recorte racial no ensino fundamental público
Authors: DE OLIVEIRA DIAS FRANCISCA AUDERLÂNIA , Silva Barbosa Nilberto Henrick , De Sousa Rosileide Pereira , PEREIRA BARBOSA JOSÉ RODRIGO , DA SILVA FILHO PEDRO DO CARMO
Published: May 2024

Na atualidade os recursos tecnológicos estão presentes nos mais variados ambientes e espaços, e as ferramentas tecnológicas utilizadas para inúmeras finalidades que perpassa pela comunicação; ensino; aprendizagem; informação; divulgação. A expansão e as possibilidades trazidas pela tecnologia requer adaptações e inovações, e muitas vezes são de difícil acessos, sobretudo quando levamos em consideração o recorte racial em que pretos, negros e pardos estão a margem de oportunidades,  gerando um acúmulo de desvantagens nas quais se incluem a falta ou pouco acesso aos recursos tecnológicos que contribuam para o processo de aprendizagem educacional. Pensando nisso é necessário investigar o uso dessas ferramentas em ambientes  que contribuem para uma formação humana e cidadã a exemplo do ambiente escolar. Nele estão presentes desafios para a utilização dessas ferramentas, mas também encontram-se possibilidades aos quais  norteiam os objetivos desse estudo. Trata-se de um estudo bibliográfico e empírico, realizado com profissionais e estudantes do 9º  ano “A” da  EEIF Dr. João Gonçalves de Souza do distrito de Mangabeira, município de Lavras,  interior do estado do Ceará.
Voto Logo Existo? Uma investigação empírica da relação entre democracia e felicidade
Authors: Werneck Carlos Eduardo Rebouças , Goés Assis Simone de Araujo
Published: May 2024

Este trabalho realiza uma investigação da relação entre democracia e felicidade. Primeiro, de maneira ampla e depois por meio de três estudos de caso: nos Estados Unidos, Brasil e Estônia. Utilizando uma abordagem quantitativa, são aplicados métodos de regressão logística e o modelo causal impact para analisar os dados. Os resultados revelam percepções quantitativas positivas sobre como a democracia afeta a felicidade em diferentes contextos culturais e políticos, além de aspectos socioeconômicos. Além disso, o uso do modelo causal impact permite examinar os efeitos causais da democracia na felicidade em choques adversos, de modo que aborda o impacto de mudanças significativas nas instituições políticas no bem-estar dos indivíduos. Os resultados fornecem uma compreensão mais aprofundada dessas complexas interações entre democracia e bem-estar subjetivo, que sugere uma relação positiva entre democracia e felicidade e com efeito ressaltado em casos de choques institucionais.
EXPLORATION OF INDIGENOUS PLANT GROWTH PROMOTING FUNGI (PGPF) AS BIOLOGICAL CONTROL AGENTS AND BIOFERTILIZER
Authors: Asniwita Asniwita , Novalina Novalina , Syarif M. , Bestari Andini Vermita , Obura Bruce Ochieng
Published: May 2024

This groundbreaking study ventures into uncharted territory to explore the vast potential of Plant Growth Promoting Fungi (PGPF) as multifaceted allies in agricultural sustainability. Departing from traditional paradigms, the research sets out to identify and characterize non-pathogenic fungal isolates with the capacity to serve as potent PGPF agents. Employing a pioneering approach, fungal isolates are meticulously collected from the rhizosphere of plants, heralding a new era of ecological exploration at the microorganism level. Rigorous testing for pathogenicity on soybean seeds unveils a rich reservoir of fungi diversity, with 18 isolates demonstrating remarkable efficacy in enhancing germination rates and promoting vigorous seedling growth. These findings not only underscore the pivotal role of PGPF in bolstering plant health and resilience but also herald a paradigm shift in sustainable agriculture. With the potential to serve as biopesticides for plant protection and biofertilizers for enhancing growth, these PGPF isolates offer a promising avenue for reducing reliance on synthetic inputs and mitigating environmental impacts. Moreover, their integration into integrated disease management strategies holds the promise of synergistic efficacy, paving the way for holistic approaches to agricultural sustainability. This research not only expands the frontiers of knowledge surrounding PGPF but also lays the groundwork for transformative innovations in agroecological practices, ushering in a greener, more resilient future for global agriculture.
REVOLUTIONIZING TOURISM: UNLEASHING THE POWER OF EXPERIMENTAL DESIGN
Authors: Purnomo Sodik Dwi , Retnowati Diah , Zumaeroh Zumaeroh
Published: May 2024

Developing tourism attractions in regions is essential to boost local communities' well-being and revenue. However, these attractions face challenges from various sources, including internal and external factors like funding and development strategies. This study focused on identifying financing sources and effective strategies for developing tourism attractions in the region, using Serulingmas Interactive Zoo in Banjarnegara Regency as a case study. The research methods were contingent valuation method, logistic regression, and SWOT analysis. This study's main novelty is its approach, blending the Contingent Valuation Method, Binary Logistics Regression Analysis, and SWOT Analysis to tackle the research question. It also conducted experiments with three distinct questionnaires. The research results showed that to increase revenue as a source of financing, Serulingmas Interactive Zoo could increase ticket prices by IDR 6,505.62 on weekdays and weekends. The development strategy of Serulingmas Interactive Zoo emphasized opportunities and strengths through the SO and WO strategies and minimized weaknesses and threats through the ST and WT strategies. This research implication suggests boosting funding for Serulingmas Interactive Zoo by raising entrance fees and using strategic approaches (SO, WO, ST, and WT) to enhance its performance. It also hints at broader implications for various domains and highlights areas for future research and unanswered questions.
TROSO WEAVING FESTIVAL: A CATALYST FOR CULTURAL CO-CREATION
Authors: Indaryani Mamik , Lusianti Dina , Zuliyati Zuliyati , Rahmawati Noor Indah , Krisnanda Krisnanda , Yusof Rushami Zien
Published: May 2024

This research aims to analyze the role of the Troso Weaving Festival in Jepara, Central Java, Indonesia, with formation as cultural value co-creation. Professional organizers and event experience can impact the emergence of a sense of happiness and unforgettable experience, leading to loyal consumers. Continuous consumers feel loyal and willing to volunteer to invite people to follow the Troso Weaving going to Troso Universal Coverage. This research method uses an exploratory approach considering the need to uncover new insights, understand complex relationships, and overcome existing knowledge gaps in co-creation. The respondents in this study were Troso Weaving Festival Visitors of 310 respondents. This study uses the theory of social cognitive approach to form the cultural value of co-creation. The analysis tool used a structural equation model by partial least squares. The research showed that Professional organizers positively affect the event experience. Entertainment, social contact and interaction, exploration of culture, and togetherness as cultural values are influential in experiencing event festival visitors. Event experience has contributed to mediating Professional organizers in cultural values co-creation. This implies that festivals can involve customers in creating co-creation value, which impacts Troso weaving worldwide, thus creating economic growth in Indonesia.
PUMAKKAL FORMULA FOR MAKING SHRIMP POND WASTE FERTILISER
Authors: Sutanto Agus , Sari Kartika , Santoso Handoko , Widowati Hening , Fidiastuti Hasminar Rachman , Rukayadi Yaya
Published: May 2024

One way to decompose the pond waste sediment is to use the liquid nutrient culture media (NB) called Pumakkal as a starter formula. However, bioremediation in shrimp ponds paid less attention despite being massively promoted by the official government. East Lampung produced 11.6 million m3 of liquid waste and 4.077 m3 of sediment waste in shrimp ponds rich in organic matter. However, they will poison the pond if they are unchecked. This study investigated how Pumakkal decomposed shrimp pond waste with three parameters: macronutrients, micronutrients, and pH. The study employed laboratory experiments, and the research was a completely randomised design (CRD) with 15 factorial arrangements. The sample was 65 kg of shrimp pond waste and 65 litres of liquid waste. They were analysed with five treatment experiments: three treatments of liquid waste media (LW), sediment waste (SW), and mixed liquid and sediment waste (MLS). The results showed that the treatment of the CE 15 isolate (with MLS significantly improved (p<0.05) fertiliser quality. Bioremediation using Pumakkal CE is the best treatment with MLS, obtaining the fertiliser with the best macronutrient: Nitrogen (N) 1,3%, Phosphorus (P)2,3%, and Potassium (K) 2,3%; C-organic 23%, C/N ratio 29; micronutrient: Fe:155 ppm, Cu: 51 ppm, Zn: 72 ppm, Mn; 51 ppm, B; 25 ppm, and Mo: 8 ppm, and pH 5-6. The mixture of liquid and pond sediment waste produces the best fertiliser suitable for plant fertiliser users. The study implies that Pumakkal applies to decomposing harmful waste sediment to support the bioremediation program.
DISTANCE E-LEARNING AND ITS IMPACT ON UNIVERSITY EDUCATION OUTCOMES FROM THE STUDENTS’ POINT OF VIEW
Authors: AL-Momani Mohammad Omar , AL-Momani Manal Abdul Karim , Hamadat Mohammad Hasan , Murtada Mariam Ayed
Published: May 2024

This pioneering study aimed to unravel the nuanced impact of distance e-learning on the outcomes of university education, specifically gauging the perspectives of Jordanian university students while considering the variables of gender and academic year. Employing a multifaceted methodology, the research adopted a descriptive approach augmented by an electronically distributed questionnaire, meticulously tailored to assess students' perceptions. A diverse cohort of 1,000 male and female students, selected through a rigorous random sampling method, participated in the study during the inaugural semester of the 2023/2024 academic year. Results unveiled a strikingly high perceived impact of distance e-learning on university education outcomes, with an average score of 3.70 and a standard deviation of 0.62, indicative of a robust consensus among students. Intriguingly, while concerns regarding the negatives of e-learning dominated discourse, the positives of distance education also garnered substantial recognition, albeit ranking slightly lower. Furthermore, the field of outcomes of distance e-learning emerged with a moderate degree of impact, underscoring the multifaceted nature of its influence. Notably, statistical analysis revealed no discernible differences in perceptions across gender or academic year cohorts, suggesting a uniform perspective on the efficacy of distance e-learning among Jordanian university students. These findings not only enrich scholarly discourse but also offer valuable insights for educational policymakers and practitioners seeking to optimize the integration of e-learning modalities in university settings.
The Effectiveness of Using the Two Stay Two Stray Type Cooperative Model in Learning to Write Negotiation Text
Authors: Dewi Nurhasani Cantika
Published: May 2024

The basis of the research background is based on the curiosity of how this type of two stay two stay cooperative model is used in text-based learning, especially in negotiating text material in class X. So that it produces a problem formulation, namely whether the two stay two stray type of cooperative model in text learning is this negotiation effective? This study intends to determine the effectiveness of the two-stay two-stray cooperative model. In this study using an experimental method with a one-group pretest-posttest design. A total of 25 students from class X MIPA 5 were sampled in the study. From the results of the study, it was proven that the initial test and final test showed an increase with an average initial test of 56.36 and an average of 67.6 in the final test. So that, it can be concluded that the two stay two stray type of cooperative model is effectively used in learning to write negotiating texts.
Playing Schumann Again for the First Time
Authors: Bobby Mitchell
Published: May 2024

How can one learn to improvise convincingly within the context of the nineteenth-century piano repertoire? And why is it important to improvise on this repertoire in the twenty-first century? Taking the music of Robert Schumann (1810−56) as a departure point, Playing Schumann Again for the First Time proposes an answer to these questions through methods towards a pianistic practice that is driven by experimentation and strives to continually find more layers where improvisation can take place, both in sounding musical practice and in notation. These practice-based methods are contextualized by a discussion of the presence of improvisation in Western classical musical practice in the nineteenth century. They are then substantiated by an argument to use improvisation as a tool for rethinking the current performance practice of nineteenth-century music. Improvisation itself and the concepts driving this term will also be addressed: improvisation in musical performance will be described as a process guided by a feedback loop between mimesis and morphosis with which the practitioner engages using his or her individual cognitive and embodied approach to listening, forgetting, and conceptualizing; the results of which bear his or her own sonic signature. The knowledge gained in this project lies within the realm of what will be described as improvisation as practice, a category of improvisational behavior that circumvents the need to be presented as art and is rather intended for the development of one’s own music-making.
Emergent Physics in Metal−Organic Frameworks
Authors: Sun Lei , Wang Shaoze , Wang Yingchao , Sun Haozhou
Published: May 2024

Many-body interactions in condensed matter could lead to emergent
phenomena spanning superconductivity, ferromagnetism, and exciton
condensation, etc. The emergence of these phenomena often requires
highly ordered spatial arrangements of the inter-acting species to
enforce specific space symmetries and interacting strengths.
Metal−organic frameworks (MOFs), crystalline materi-als formed by
self-assembly of metal ions and organic ligands, allow precise design of
their crystal structures and sophisticated tun-ing of Coulombic
interaction or magnetic coupling among lattice sites. Such atomic-level
designability combined with high crystallin-ity and versatile types of
lattices (e.g. kagome and honeycomb lattices) render MOFs as a great
platform to investigate emergent physics. In this Emerging Topic, we
summarize recent studies evidencing emergent phenomena in MOFs including
strong correla-tions, superconductivity, charge density wave, long-range
magnetic order, and quantum spin liquid. We highlight the great
potential of MOFs as quantum materials and discuss challenges including
growth of high-quality single crystals and in-depth physical
charac-terizations to reveal insights into the nature of physical
properties of MOFs.
A self-assembled nanomedicine for glucose supply interruption-amplified low-temperature photothermal therapy and anti-prometastatic inflammatory processes of triple-negative breast cancer
Authors: Wang MingCheng , Yi Huixi , Zhan Zhixiong , Feng Zitong , Yang Gang-Gang , Zheng Yue , Zhang Dong-Yang
Published: May 2024

The poor prognosis of triple-negative breast cancer (TNBC) resulting
from its high metastasis, whereas inflammation accompanied by excessive
reactive oxygen species (ROS) is prone to aggravate tumor metastasis.
Although photothermal therapy (PTT) has extremely high therapeutic
efficiency, the crafty tumor cells allow increase the expression of heat
shock proteins to limit its effect, and PTT induced inflammation is also
thought to be a potential trigger for tumor metastasis. Herein,
myricetin, iron ions and polyvinylpyrrolidone were utilized to develop
nanomedicines by self-assembly strategy for the treatment of metastatic
TNBC. The nanomedicines with marvellous water solubility and dispersion
can inhibit glucose transporter 1 and interfer with mitochondrial
function to block the energy supply of tumor cells, achieving starvation
therapy on TNBC cells. Nanomedicines with excellent photothermal
conversion properties allow down-regulate the expression of HSPs to
enhance the effect of PTT. Interestingly, the broad spectrum of ROS
scavenging ability of nanomedicines successfully attenuat PTT induced
inflammation as well as regulate metastasis-related proteins through
glycometabolism inhibition to reduce tumor cell metastasis. Moreover,
the nanomedicines have negligible side effects and good clinical
application prospect, which provides a valuable paradigm for the
treatment of metastatic TNBC through glycometabolism interference,
anti-inflammation, starvation and photothermal synergistic therapy.
A vizeletretenciót imitáló petefészekciszta különös esete
Authors: Nagy Noémi Dalma , Romics Miklós , Supák Dorina
Published: May 2024

Bevezetés: Petefészekciszták korosztálytól függetlenül bármelyik életszakaszban megjelenhetnek, ám leggyakrabban a fertilis korban lévő nők esetében, nőgyógyászati rutinvizsgálat során derül fény a jelenlétükre, a nemi érést megelőzően ritkán fordulnak elő. Az esetek többségében tünetmentesek, azonban előfordul, hogy – jelentős méretükből kifolyólag – olykor panaszt okozhatnak: alhasi fájdalom, intermittáló hüvelyi vérzés, bélmotilitási zavar, vagy akár húgyúti panasz is jelentkezhet. Esetismertetés: Esetünkben egy különös kázust mutatunk be, ahol egy nagyméretű (12 cm-es), alhasi panaszokat okozó dermoid ciszta ultrahangos képe keltette telt húgyhólyag benyomását, és jelentett ezáltal diagnosztikus és terápiás kihívást. Megbeszélés: Nehezen karakterizálható húgyúti tünetek esetén nőknél gondolnunk kell a petefészekciszta jelenlétére.
Az áttétes hormonszenzitív prosztatarák abirateronkezelése
Authors: Riesz Péter , Nyirády Péter
Published: May 2024

A prosztatarák férfiakban a leggyakoribb urológiai rosszindulatú megbetegedés. Gyakran áttétes formájában fedezzük fel, amikor a gyógyszeres kezeléseken van a hangsúly. Az androgéndeprivációs terápia évtizedek óta az első lépése az áttétes prosztatarák kezelésének, amelynek alapja a rákos sejtek hormonérzékenysége. Ebben az úgynevezett hormonszenzitív állapotban teljes túlélési előnyt először az ADT mellett adott korai docetaxel-kemoterápiával, majd az új típusú hormonterápiák bevezetésével tudtak kimutatni. Az új típusú hormonterápiák közé tartozik a szteroidszintézis gátlásával az abirateron-acetát. A szerzők célul tűzték ki az abirateronkezelés indikációjának, menetének, előnyeinek, mellékhatásainak ismertetését áttétes hormonszenzitív prosztatarák esetén. Napjainkban a metasztatikus prosztatarák esetén a kombinációs kezelések jelentik a standard elsővonalbeli terápiát (ADT + kemoterápia vagy ADT + új típusú hormonterápia), így minden gyakorló urológus számára hasznos ismereteket adunk át a dolgozatban.
Relationships between colorization and pseudo-colorization of monochrome images
Authors: Śluzek Andrzej
Published: May 2024

This paper investigates the relationship between colorization and pseudo-colorization techniques for converting grayscale images to color. Colorization strives to create visually believable color versions of monochrome images, either replicating the original colors or generating realistic, alternative color schemes. In contrast, pseudo-colorization maps grayscale intensities to pre-defined color palettes to improve visual appeal, enhance content understanding, or aid visual analysis. While colorization is an ill-posed problem with infinitely many RGB solutions, pseudo-colorization relies on mapping functions to deterministically assign colors. This work bridges these techniques by exploring the two following operations: first - deriving pseudo-color from colorized images - this allows for creating stylized or abstract representations from existing colorizations, and second - enriching color diversity in pseudo-colored images - this enhances visual appeal and attractiveness of pseudo-colored images. The paper emphasizes the centrality of decolorization (rgb-to-gray) models in both processes. It focuses on the theoretical underpinnings of these problems but complements them with illustrative examples for clarity.
Bivariate Lupaş-Durrmeyer type operators involving Pólya distribution
Authors: Yadav Jyoti , Mohiuddine S.A. , Kajla Arun , Alotaibi Abdullah
Published: May 2024

In this paper, we consider a bivariate extension of blending type
approximation by Lupa?-Durrmeyer type operators involving P?lya
Distribution. We illustrate the convergence rate of these type operators
using Peetre?s K-functional, modulus of smoothness and for functions in a
Lipschitz type space.
Some results for two classes of two-point local fractional proportional boundary value problems
Authors: Laadjal Zaid , Abdeljawad Thabet , Jarad Fahd
Published: May 2024

In this paper, we consider two classes of boundary value problems in the
frame of local proportional fractional derivatives. For both of these
classes, we obtain the associated Green?s functions and discuss their
properties. Using these properties, we go about the uniqueness of the
solutions. In addition, we establish Lyapunov-type and Hartman-Wintner-type
inequalities and build sharp estimated for the unique solutions of the
considered equations.
Inverse coefficient problem for quasilinear pseudo-parabolic equation by fourier method
Authors: Bağlan İrem , Akdemir Ahmet , Dokuyucu Mustafa
Published: May 2024

In this research, we consider a coefficient problem of an inverse problem of
a quasilinear pseudo-parabolic equation with nonlocal boundary condition. We
prove the existence, uniqueness and continuously dependence upon the data of
the solution by iteration method. Also we consider numerical solution for
this inverse problem by using linearization and finite difference method.
Clinical and dermoscopic spectrum of age-dependent spitzoid lesions - when to react?
Authors: Masirevic-Mudric Iva , Popadic Svetlana , Lalosevic Jovan
Published: May 2024

Introduction. Spitzoid lesions represent a spectrum of melanocytic lesions comprising benign Spitz nevi, intermediate lesions known as atypical Spitz tumors, and Spitzoid melanoma. They tend to be more common in children and young adults, but all age groups can be affected. Due to complexity of their clinical, dermoscopic and histological differentiation, they are extremely difficult to manage, especially in pediatric population. Outlines of cases. In this report, we present a series of six cases with spitzoid lesions in different age groups with different outcomes. Conclusion. With the following case series, we report clinical and dermoscopic features of biologically various spitzoid lesions, appearing in different age groups. We believe that this article will increase knowledge of both physicians and dermatologists about when and how to react when dealing with a patient with spitzoid lesion.
Glucose Transporters Are Key Components of the Human Glucostat
Authors: Caspi Inbal , Tremmel Daniel M. , Pulecio Julian , Yang Dapeng , Liu Dingyu , Yan Jielin , Odorico Jon S. , Huangfu Danwei
Published: May 2024

Mouse models are extensively used in metabolic studies. However, inherent differences between the species, notably their blood glucose levels, hampered data translation into clinical settings. In this study, we confirmed GLUT1 to be the predominantly expressed glucose transporter in both adult and fetal human β-cells. In comparison, GLUT2 is detected in a small yet significant subpopulation of adult β-cells and is expressed to a greater extent in fetal β-cells. Notably, GLUT1/2 expression in INS+ cells from human stem cell-derived islet-like clusters (SC-islets) exhibited a closer resemblance to that observed in fetal islets. Transplantation of primary human islets or SC-islets, but not murine islets, lowered murine blood glucose to the human glycemic range, emphasizing the critical role of β-cells in establishing species-specific glycemia. We further demonstrate the functional requirements of GLUT1 and GLUT2 in glucose uptake and insulin secretion through chemically inhibiting GLUT1 in primary islets and SC-islets and genetically disrupting GLUT2 in SC-islets. Finally, we developed a mathematical model to predict changes in glucose uptake and insulin secretion as a function of GLUT1/2 expression. Collectively, our findings illustrate the crucial roles of GLUTs in human β-cells, and identify them as key components in establishing species-specific glycemic set points.

Article Highlights
Reduced Thalamic γ-Aminobutyric Acid (GABA) in Painless but Not Painful Diabetic Peripheral Neuropathy
Authors: Shillo Pallai , Sloan Gordon , Selvarajah Dinesh , Greig Marni , Gandhi Rajiv , Anand Praveen , Edden Richard A. , Wilkinson Iain D. , Tesfaye Solomon
Published: May 2024

Alterations in the structure, function, and microcirculation of the thalamus, a key brain region involved in pain pathways, have previously been demonstrated in patients with painless and painful diabetic peripheral neuropathy (DPN). However, thalamic neurotransmitter levels including γ-aminobutyric acid (GABA) (inhibitory neurotransmitter) and glutamate (excitatory neurotransmitter) in different DPN phenotypes are not known. We performed a magnetic resonance spectroscopy study and quantified GABA and glutamate levels within the thalamus, in a carefully characterized cohort of participants with painless and painful DPN. Participants with DPN (painful and painless combined) had a significantly lower GABA:H2O ratio compared with those without DPN (healthy volunteers [HV] and participants with diabetes without DPN [no DPN]). Participants with painless DPN had the lowest GABA:H2O ratio, which reached significance compared with HV and no DPN, but not painful DPN. There was no difference in GABA:H2O in painful DPN compared with all other groups. A significant correlation with GABA:H2O and neuropathy severity was also seen. This study demonstrates that lower levels of thalamic GABA in participants with painless DPN may reflect neuroplasticity due to reduced afferent pain impulses, whereas partially preserved levels of GABA in painful DPN may indicate that central GABAergic pathways are involved in the mechanisms of neuropathic pain in diabetes.

Article Highlights
Combination SGLT2 Inhibitor and Glucagon Receptor Antagonist Therapy in Type 1 Diabetes: A Randomized Clinical Trial
Authors: Boeder Schafer C. , Thomas Robert L. , Le Roux Melissa J. , Giovannetti Erin R. , Gregory Justin M. , Pettus Jeremy H.
Published: May 2024

OBJECTIVE

To examine the effects of insulin-adjunctive therapy with a sodium–glucose cotransporter 2 (SGLT2) inhibitor and a glucagon receptor antagonist (GRA) on glycemia, insulin use, and ketogenesis during insulinopenia in type 1 diabetes.

RESEARCH DESIGN AND METHODS

In a randomized, double-blind, placebo-controlled, crossover trial we assessed the effects of adjunctive SGLT2 inhibitor therapy (dapagliflozin 10 mg daily) alone and in combination with the GRA volagidemab (70 mg weekly) in 12 adults with type 1 diabetes. Continuous glucose monitoring, insulin dosing, and insulin withdrawal tests (IWT) for measurement of glucose and ketogenesis during insulinopenia were completed during insulin-only (Baseline), SGLT2 inhibitor, and combination (SGLT2 inhibitor + GRA) therapy periods.

RESULTS

Average glucose and percent time with glucose in range (70–180 mg/dL) improved with combination therapy versus Baseline and SGLT2 inhibitor (131 vs. 150 and 138 mg/dL [P < 0.001 and P = 0.01] and 86% vs. 70% and 78% [P < 0.001 and P = 0.03], respectively) without increased hypoglycemia. Total daily insulin use decreased with combination therapy versus Baseline and SGLT2 inhibitor (0.41 vs. 0.56 and 0.52 units/kg/day [P < 0.001 and P = 0.002]). Peak β-hydroxybutyrate levels during IWT were lower with combination therapy than with SGLT2 inhibitor (2.0 vs. 2.4 mmol/L; P = 0.048) and similar to levels reached during the Baseline testing period (2.1 mmol/L). Participants reported enhanced treatment acceptability and satisfaction with combination therapy.

CONCLUSIONS

Glucagon antagonism enhances the therapeutic effects of SGLT2 inhibition in type 1 diabetes. Combination therapy improves glycemic control, reduces insulin dosing, and suggests a strategy to unlock the benefits of SGLT2 inhibitors while mitigating the risk of diabetic ketoacidosis.
An E115A missense variant in CERS2 is associated withincreased sleeping energy expenditure and hepatic insulin resistance in American Indians
Authors: Heinitz Sascha , Traurig Michael , Krakoff Jonathan , Rabe Philipp , Stäubert Claudia , Kobes Sayuko , L Hanson Robert , Stumvoll Michael , Blüher Matthias , Bogardus Clifton , Baier Leslie , Piaggi Paolo
Published: May 2024

Abstract
Genetic determinants of inter-individual differences in energy expenditure (EE) are largely unknown. Sphingolipids, such as ceramides, have been implicated in the regulation of human EE via mitochondrial uncoupling. In this study, we investigated whether genetic variants within enzymes involved in sphingolipid synthesis and degradation affect EE and insulin-related traits in a cohort of American Indians informative for 24-hour EE and glucose disposal rates during a hyperinsulinemic-euglycemic clamp. Association analysis of 10,084 genetic variants within 28 genes involved in sphingolipid pathways identified a missense variant (rs267738, A>C, E115A) in exon 4 of CERS2 that was associated with higher sleeping EE (+116 kcal/day) and increased rates of endogenous glucose production during basal (+5%) and insulin-stimulated (+43%) conditions, both indicators of hepatic insulin resistance. The rs267738 variant did not affect ceramide synthesis in HepG2 cells but resulted in a 30% decrease in basal mitochondrial respiration. In conclusion, we provide evidence that the CERS2 rs267738 missense variant may influence hepatic glucose production and post-absorptive sleeping metabolic rate.
Loss of ATP-sensitive potassium channel expression and function in the nervous system decreases opioid sensitivity in high-fat-diet-fed mouse model of diet-induced obesity.
Authors: Fisher Cole , Johnson Kayla , Moore Madelyn , Sadrati Amir , L. Janecek Jody , L. Graham Melanie , H. Klein Amanda
Published: May 2024

Abstract

During diabetes progression, β-cell dysfunction due to loss of potassium channels sensitive to ATP, known as KATP channels, occurs contributing to hyperglycemia. The aim of this study is to investigate if KATP channel expression or activity in the nervous system was altered in a high-fat-diet-(HFD) fed mouse model of diet-induced obesity. Expression of two KATP channel subunits, Kcnj11 (Kir6.2) and Abcc8 (SUR1), were decreased in the peripheral and central nervous system in HFD mice, which is significantly correlated with mechanical paw withdrawal thresholds. HFD mice had decreased antinociception to systemic morphine compared to control diet (CON) mice, which was expected as KATP channels are downstream targets of opioid receptors. Mechanical hypersensitivity in HFD mice was exacerbated after systemic treatment with glyburide or nateglinide, KATP channel antagonists clinically used to control blood glucose levels. Upregulation of SUR1 and Kir6.2, through an adenovirus delivered intrathecally, increased morphine antinociception in HFD mice,. These data present a potential link between KATP channel function and neuropathy during early stages of diabetes. There is a need for increased knowledge in how diabetes affects structural and molecular changes in the nervous system, including ion channels, to lead to the progression of chronic pain and sensory issues.
The Influence of the Inquiry Learning Model on Critical Thinking in Science Learning in Grade V Elementary School
Authors: Prasanti Ni Putu Putri , Suniasih Ni Wayan
Published: May 2024

Students’ critical thinking skills are still low, especially in science lessons. This study aims to analyze the effect of the Inquiry Learning Model on the critical thinking skills of students in science subjects in fifth grade elementary school students. This type of research is a quasy experiment with the Nonequivalent Control Group Design. The population of this study were all 160 students of fifth grade elementary school with a sample of 34 students in the experimental group and 29 students as the control group which was determined using the Cluster Random Sampling Technique. Collecting research data using the description test method consisting of 9 valid questions. Research data were analyzed using descriptive statistical analysis techniques and inferential statistical analysis techniques and then analyzed using the t-test (polled variance formula). The results showed that t-count was 3.923 and ttable was 1.999 at a significance level of 5% (α equal to 0.05) with degrees of freedom (dk) equal to 61 so that Ho was rejected. It was concluded that there was a significant influence from the application of the Inquiry learning model on critical thinking skills in science lessons for fifth grade elementary school students. This research makes a new contribution in understanding the effectiveness of the inquiry learning model in increasing critical thinking in fifth grade students.
Improving Students' Critical Thinking Skills with The Discovery Learning Model Assisted by Realia Learning Media
Authors: Ardita Made Widya , Agustika Gusti Ngurah Sastra , Wiyasa I Komang Ngurah
Published: May 2024

Science learning emphasizes the provision of understanding, experience and direct practice to develop students' potential. But the facts on the ground show that the learning conditions in schools have not gone well. This study aims to determine the effect of the Discovery Learning model assisted by realia media on the critical thinking skills of science content in fifth grade elementary school students. This study was a quasi-experimental design using the Nonequivalent Control Group Design. The population in this study were 190 students with two sample groups, namely the experimental group which consisted of 38 students and the control group which consisted of 37 students. Methods of data collection using a test form of description. The research data were analyzed using descriptive statistical analysis techniques and inferential statistical analysis techniques using the t-test. The results of the analysis of the hypothesis showed that tcount was 3.407 and ttable was 1.993 with a significant level of 5% and dk = 73. Because tcount 3.407 was greater than ttable 1.993, Ha was accepted that there are differences in students' critical thinking skills in science content who are taught with the Discovery Learning model assisted by realia media and the group of students who are not taught with the Discovery Learning model assisted by realia media in fifth grade elementary school students.
Dehydration and Environmentally Friendly Thermal Processing of Excess Activated Sludge
Authors: Iskhakova R. Ya. , Nurgaliev A. I.
Published: May 2024

Introduction.Currently, there is a problem with the accumulation of large amounts of production waste. One type of this waste is excess activated sludge, which is a waste product from biological wastewater treatment that has a high moisture content. When excess activated sludge is deposited in beds, problems can arise related to changes in the gas-air environment, the release of unpleasant odors, as well as the contamination of groundwater and soil. Prolonged presence of sediment in sludge beds in oxygen-free conditions leads to its decay and deterioration of moisture-yielding properties. For these reasons, the development of new methods for disposing of large volumes of waste generated during wastewater treatment is essential. The aim of this research is to develop a technique for preliminary neutralization and thermal treatment of excess activated sludge using energy waste.Materials and Methods.The work used excess activated sludge with a moisture content of 98.2% (waste of hazard class IV). Water treatment sludge (waste of hazard class V) was used as a reagent to increase moisture yield. For experimental studies on dehydration, a laboratory centrifuge Elmi CM-6M.01 was used. Tests were conducted under various conditions (500, 1 000, and 1 500 revolutions per second for 1, 2, and 3 minutes), and the value of centrifugation was determined as a criterion for moisture yield in the sludge. Fuel pellets were produced by rolling with technical lignosulfonate as a binding agent. Elemental analysis of the samples was conducted to study the possibility of thermal treatment using an EA 3 000 Euro Vector Analyzer.Results.A comprehensive technology has been developed to clean the resulting gas emissions from solid particles formed during the combustion of fuel pellets and remove them from the furnace in the form of fly ash along with the outgoing gases. This technology also removed sulfur oxides, nitrogen oxides, and polychlorinated dibenzodioxins and dibenzofurans, while beneficially utilizing flue gas heat by reducing its temperature from 900–1 200°C to 140°C.Discussion and Conclusion.The approach proposed in this article for the processing and disposal of large volumes of waste allows for the reduction of moisture content of excess activated sludge and the use of this waste as a secondary energy source. This method is environmentally friendly and addresses both technical and environmental challenges, such as the effective recycling of industrial waste and reducing the anthropogenic impact on soil, air, and groundwater. It also provides an opportunity to generate additional electrical and thermal energy through thermal utilization of waste. The results of this work indicate that it is possible to integrate the use of various types of industrial waste (sewage sludge, water treatment waste, and pulp and paper industry waste) as secondary energy sources. These findings have practical implications for enterprises in both the municipal and industrial sectors with wastewater treatment facilities.