Integral indexes of intoxication in caninae coronaviridae enteritis
Authors: Radsikhovskii M. , Goralskii L. , Borissevich B. , Dyshkant O. 
Published: July 2019

In this article to be spoken about indicators of action of coronaviridae on an organism of animals – qualitative and quan-titative characteristics of blood. These indicators change at many patological reactions and participate in ensuring nonspe-cific and specific resistance of an organism.

With the help of the analysis of integral leukocyte indices based on the formula of blood reflecting the state of neurohumoral homeostasis and immunological reactivity of the organism, the violations were first discovered and established humoral and cellular links of the immune system, micro- and macrophage system, reduction of nonspecific protection of the organism and revealed connections between integral hematological parameters and immunity indexes in dogs with experimental and natural infection with coronavirus.

In animals in the natural course of coronavirus enteritis there were changes in the indexes of intoxication: a significant increase in the leukocyte index of intoxication, the indicator of reactivity of the organism, the index of leukocyte shift of blood and the index of intoxication, and significant decrease in the nuclear index, the general index and the leukocyte index in indices of nonspecific reactivity, a significant increase in the ratio of neutrophils and lymphocytes, the ratio of neutrophils and monocytes, the ratio of eosinophils to leukocytes and the ratio of segmental neutrophils and bands neutrophils, a significant decrease in the ratio of lymphocytes and monocytes, the index of ratio of lymphocytes and eosinophils, the index of Garkavy, index allergy and immunoreactivity index in indexes of activity of inflammation, a significant decrease of the ratio of leukocytes and ЕSR, the lymphocytic granulocytic index and the ratio of lymphocytes and monocytes to the ESR.

Experimental infection revealed changes in the indexes of intoxication: a significant increase in the leukocyte index of intoxication, the nuclear index and the index of blood leukocyte shift, a significant decrease in the indicator of reactivity of the organism, the general index, the leukocyte index and the indicator of intoxication in the indices of nonspecific reactivity, a significant increase in the ratio of neutrophils and lymphocytes to the index ratio of eosinophils to leukocytes, a significant decrease in the ratio of lymphocytes and monocytes, the index of ratio of lymphocytes and eosinophils, the Garkavy index, the ratio of segmental neutrophils and bands neutrophils and the index of immunoreactivity in the activity indices, a significant decrease in the ratio of leukocytes and ESR and lymphocytic granulocytic index.

Integral hematological parameters of peripheral blood have been proved to increase the informative value of the general analysis of blood in dogs with infectious diseases and allow to determine not only the degree of reactivity of the organism, but also to assess the level of endogenous intoxication.

Key words: coronavirus enteritis, natural infection, experimental infection, hematological indices.