bluuebunny/crossref_metadata_2025 huggingface dataset:
The Role of Self-Expandable Metallic Stents in the Treatment of Malignant Strictures in all Segments of the Gastrointestinal Tract
Authors: Çağatay A. K. , Sayar Süleyman , Kılıç Ebru Tarıkçı , Kahraman Resul , Öztürk Oğuzhan , Özdil Kamil
Published: January 2023

Objectives:

Management of malignant gastrointestinal (GI) obstruction presents a significant challenge. Most patients are in a profoundly decompensated state due to underlying malignancy and are not ideal candidates for invasive surgical procedures. Self-expandable metallic stents (SEMSs) are used to provide permanent or temporary patency in all endoscopically accessible stenosis of the GI tract. In this study, it is aimed to analyse the characteristics and the efficacy of patients with malignant stenosis treated with SEMS, in all segments of the GI tract.

Material and Methods:

The sample consisted of 60 patients who underwent SEMS replacement, between 10 March 2014 and 16 December 2020, to treat malignant-related strictures in the GI tract at the Gastroenterology Department of the Health Sciences University Umraniye Training and Research Hospital. The data of the patients, hospital data processing database and electronic endoscopic database records were retrospectively scanned and recorded. The general characteristics of the patients and the treatment-related features were analysed.

Results:

The mean age of patients who were placed SEMS was 69.7 ± 13.7 years. Uncovered (15%, n: 9), fully covered (13.3%, n: 8), or partially covered (71.6%, n: 43) SEMS were successfully placed in all patients. Clinical success in patients with SEMS was 85.7% in the esophagus, 100% in the small intestine and 90.9% in the stomach and colon. About 11.4% migration, 14.2% pain, 11.4% overgrowth and 5.7% ingrowth were detected in patients who had SEMS placed in the oesophagus. Pain was detected in 9.1% and ingrowth in 18.2% of patients who had SEMS placed in the stomach. Pain was detected in 18.2% of the patients who had SEMS placed in the colon and migration was found in 9.1%.

Conclusion:

SEMS implant is a minimally invasive effective method in the palliative treatment of malignant strictures of the GI tract.
Life before Death in India: A Narrative Review
Authors: Mir Wasey Ali Yadullahi , Misra Sudha , Sanghavi Devang
Published: January 2023

Palliative care is an ever-increasing need in India, with its large population and rising burden of chronic illness. India ranks 67thout of 80 countries in the quality of death index, which measures the availability and quality of palliative care. Community-led projects in Kerala have proven successful in improving palliative care access with modest resources and volunteer involvement. In India, the number of hospice facilities is increasing; however, <1% of the Indian population has access to palliative care. Financial and human resources limitations in the health-care system, poverty and high health-care expenditure, the lack of awareness among the public about end-of-life care, hesitance to seek care due to social stigma, strict laws regarding opiates that hinder adequate pain relief and the apparent conflict between traditional social values and western values regarding death are the major obstacles to improving palliative care. Significant efforts focused on public awareness of end-of-life care and locally-tailored programmes with family and community involvement are necessary to address this issue and integrate palliative care into the primary care system. Furthermore, we discuss the effects of the COVID-19 pandemic that has been managed effectively by palliative care involvement.
DEVELOPMENT OF PREDICT-OBSERVE-EXPLAIN (POE) BASED AUTHENTIC PROBLEMS’ INSTRUCTIONAL PACKAGE TO IMPROVE STUDENTS’ CRITICAL THINKING SKILLS
Authors: Noor Aulia Fauzan , Yunus Rahmat , Suyidno Suyidno , Fahmi Fahmi
Published: January 2023

Science instruction is required to be able to develop critical thinking skills and solve various authentic problems. However, based on the preliminary study results, the science learning process does not emphasize the development of critical thinking skills. Therefore, this study aims to produce appropriate POE (Predict-Observe-Explain) based authentic instructional package that are valid, practical, and effective to improve students' critical thinking skills. This research is educational development research using Tessmers' development model, which includes self-evaluation, expert test, individual test, small group test, and field test. The subjects of the research trial were eight students of class VIIIE and 29 students of class VIIIF of SMPN 33 Banjarmasin. The research data were obtained by expert testing on assessment using validation instruments, observations on practicality assessment using RPP implementation instruments, and tests on effectiveness assessment using critical LP instruments. The results of the data were analyzed quantitatively and qualitatively and the results obtained that the learning tools were categorized as very valid, practical, and effective. Therefore, a POE (Predict-Observe-Explain) based authentic problem instructional package is feasible to improve students' critical thinking skills.
CXCR4 is Involved in the Regulation of the Functions of c-Src in RCC Development
Authors:   Department of Urology, Changhai Hospital, Naval Medical University (Second Military Medical University),Shanghai, People’s Republic of China, R Yan , Q Pang ,   Department of Urology, Changhai Hospital, Naval Medical University (Second Military Medical University),Shanghai, People’s Republic of China, J Chen ,   Department of Urology, Henan Provincial Corps Hospital of Chinese People’s Armed Police, Zhengzhou, People’s Republic of China, J Shi ,   Department of Urology, Changzheng Hospital, Naval Medical University (Second Military Medical University), Shanghai, People’s Republic of China, X Gan ,   Department of Urology, Changhai Hospital, Naval Medical University (Second Military Medical University),Shanghai, People’s Republic of China, L Wang ,   Department of Urology, Changhai Hospital, Naval Medical University (Second Military Medical University),Shanghai, People’s Republic of China
Published: January 2023

Renal cell carcinoma is a common malignant urinary tumor and CXCR4 plays an important role in the development of renal cell carcinoma. However, the role of c-Src gene in the development of renal cell carcinoma is still unclear. In this study, we found that CXCR4 can directly bind to SRC and CXCR4 is involved in the regulation of c-Src expression. C-Src is highly expressed in renal cell carcinoma and promotes cell division, proliferation, invasion and reduces apoptosis in renal cell carcinoma. Highly expressed c-Src is associated with poor prognosis in patients with RCC, and affects the infiltration of CD4+ T cells and macrophages in the tumor microenvironment. In addition, high SRC expression is associated with the expression of multiple immune checkpoints, high tumor mutation burden and high microsatellite instability which indicates the potential of SRC to predict the response to the immune checkpoint block therapy.
In-Silico Modelling and Analysis of the Effect of Immusante on Immune System and Cancer Pathology
Authors:   MetFlux Research Private Limited, Mumbai 400078, India, A Garg , A Lomore ,   MetFlux Research Private Limited, Mumbai 400078, India, V Gangwar ,   MetFlux Research Private Limited, Mumbai 400078, India, K Korla ,   MetFlux Research Private Limited, Mumbai 400078, India, SS Bhat ,   Research and Development, Himalaya Wellness, Bengaluru 562162, India, RP Rao ,   Research and Development, Himalaya Wellness, Bengaluru 562162, India, M Rafiq ,   Research and Development, Himalaya Wellness, Bengaluru 562162, India, R Kumawat ,   Research and Development, Himalaya Wellness, Bengaluru 562162, India, UV Babu ,   Research and Development, Himalaya Wellness, Bengaluru 562162, India, KV Venkatesh ,   MetFlux Research Private Limited, Mumbai 400078, India
Published: January 2023

Cancer therapy has been at the centre stage for decades in the scientific fraternity. Several chemical and biochemical actives have been studied for their effect on cancer therapy. In the present study, we have studied the therapeutic effects of a herbal formulation, Immusante, containing bioactive compounds such as Apigenin, Quercetin, Betulinic Acid, and Oleanolic Acid on cancer cell proliferation, angiogenesis and survival. The immunomodulatory effects of Immusante were incorporated in a cancer-specific mathematical model to quantify the therapeutic effects. Cancer model simulation with Immusante showed a significant reduction of tumour proliferation, reduction of immunosuppressive species, and increase in the CD8 effector T cell function. The effect of the Immusante, along with a chemotherapy drug, 5-fluorouracil (5-FU), was simulated to assess the effect of combination therapy. The addition of 5-FU as a monotherapy showed a 28% increase in the population with no/ very low tumorigenesis. A combination of 5-FU and Immusante showed a 44% increase in the population with no/very low tumorigenesis. A similar trend was seen for population size with low immune suppression, where 5-FU monotherapy showed a 26% increase, Immusante showed 12%, and a combination of 5-FU and Immusante showed a 43% increase in the population with low immune suppression, indicating increased efficiency of effector species in the presence of Immusante. Similar results were obtained for other drugs such as Cyclophosphamide, Platinum-based drugs, Vincristine, Taxane, Irinotecan, and Anthracyclines combined with Immusante. It is observed that chemotherapy alone can bring clearance in the tumour, further augmented by incorporating Immusante as a herbal adjuvant. Simulations suggest that combination enhances effectiveness and reduces the side effects of chemotherapy. It was observed that Immusante could effectively counter side-effects and adaptive response of cancer cells to improve efficacy and normalize immune response. The immunomodulatory properties of Immusante have been shown to restore balance in immune response and reduce the cytotoxic effects of drugs on healthy organs. These characteristics make Immusante a promising adjuvant during cancer management and improve the quality of the treatment.
Stereotactic Body Radiation Therapy for Pulmonary Oligometastasis from Head and Neck Cancer: The Potential Survival Benefits from PD-1 Inhibitors
Authors:   The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, China, Y Hua , N Liu ,   The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, China, T Jin ,   The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, China, Q Jin ,   The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, China, Q Hu ,   The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, China, R Dong ,   The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, China
Published: January 2023

Objective: Stereotactic body radiotherapy is suitable for most pulmonary oligometastasis, but there is little data that reported the different values of SBRT combined with systemic therapy between NP and non-NP cancers. Method: This was a retrospective study on patients with pulmonary oligometastatic HNC treated with SBRT at Zhejiang Cancer Hospital. Main Results: A total of 43 patients with 65 pulmonary metastatic lesions were included in the study.24 cases originated from NP cancer, and 19 originated from non-NP cancer. The median follow-up time was 29.7 months. The 1-year local control rate was 95.4%, and 3-year PFS and OS2 were 68.7% and 46.0% in the whole group. Subgroup analysis showed local control rates were 95.1% and 95.8% in the NP group and non-NP group (p=1.000). Median PFS times were 47.0 months and 13.3months (p=0.006), and 3-year OS2 was 87.1% and 47.9% in the two groups (p=0.011). Primary tumor location, time to metastasis, number of pulmonary lesions, BED, and systemic therapy were found to be significant predictors for PFS and (or) OS2 in univariate analysis. Systemic therapy and the number of pulmonary lesions were maintained in Cox regression analysis. No SBRT-related toxicity above grade 3 was observed. Conclusion: SBRT is an effective and tolerable therapy for patients with pulmonary oligometastasis from HNC. On the basis of systemic treatment, radical curative-intent with SBRT could be achieved in selected HNC patients.
Combinational Therapy with Aspirin and Ticagrelor Alleviates Vascular Inflammation and Angiotensin IIdriven Abdominal Aortic Aneurysm Formation in Mice
Authors:   Department of Cardiology, Zhejiang Hospital, Hangzhou, Zhejiang, P. R. China, X-W Liu , Y-Z Weng ,   Department of Cardiology, Zhejiang Hospital, Hangzhou, Zhejiang, P. R. China, J-G Lou ,   Department of Cardiology, Zhejiang Hospital, Hangzhou, Zhejiang, P. R. China, X-F Chen ,   Department of Cardiology, Taizhou Hospital, Wenzhou Medical University, Taizhou, Zhejiang, P. R. China, C-Q Du ,   Department of Cardiology, Zhejiang Hospital, Hangzhou, Zhejiang, P. R. China, L-J Tang ,   Department of Cardiology, Zhejiang Hospital, Hangzhou, Zhejiang, P. R. China
Published: January 2023

Background: Abdominal aortic aneurysm (AAA) is a severe form of blood vessel-related disease. Medial degeneration and inflammation are typical characteristic of AAA. Activated platelets release many pro-inflammatory cytokines and participate in the initial inflammatory response to various vascular diseases. Although there are some studies on the effects of APAs on AAA, it is yet unknown whether the new P2Y12 receptor inhibitor ticagrelor (T) can inhibit AAA. Herein, we explored the consequences of ticagrelor exposure on AAA progression and determined whether a combinational therapy, involving T and aspirin (A), exerts a stronger inhibitory effect in vivo. Methods: AAA was established in apolipoprotein E-deficient (ApoE-/- ) mice via a 28-day administration of angiotensin II (Ang II). Next, the mice were arbitrarily separated into 5 groups: saline infusion alone (sham), Ang II infusion alone, Ang II infusion plus oral A (10 mg•kg-1•d-1), Ang II infusion plus oral T (120 mg.kg-1.d-1), Ang II infusion plus combinational therapy with A (10 mg•kg-1•d-1) and T (120 mg.kg-1.d-1). Results: The combined treatment markedly suppressed the Ang II-driven elevation of maximal aortic diameter, aneurysm formation (26.7% decrease, P<0.05), alterations in aortic expansion, elastic lamina destruction, platelet deposition, and inflammatory cytokine accumulation. In addition, it also diminished matrix metalloproteinase (MMP)-2 and MMP-9 production. Conclusions: A combinational therapy of A and T, but not individual drugs, inhibits Ang II-driven AAA generation in mice in vivo, and this process may be regulated by a suppressed inflammatory response.
Enormous Pulmonary Arteries and a Late Diagnosis of a Common Congenital Cardiac Issue: A Case Report
Authors:   Department of Cardiology, Tullamore Regional Hospital, Tullamore, Co Offaly, Ireland, G Murphy , P Shiels ,   Department of Cardiology, Tullamore Regional Hospital, Tullamore, Co Offaly, Ireland
Published: January 2023

Background: Noonan’s syndrome is the second most common congenital cardiac syndrome after Down syndrome. Classically it is associated with pulmonary stenosis, Hypertrophic Cardiomyopathy (HCM), and Atrial Septal Defects (ASD). Late presentations, milder phenotypes and atypical presentations can occur in adult life and have cardiovascular implications. Case Summary: A 62-year-old presented to the emergency department with chest pain and atrial fibrillation with fast ventricular rate and RBBB morphology. A transthoracic echocardiogram demonstrated a massive Pulmonary Artery (PA), concerning for pulmonary hypertension and an atrial septal defect (ASD). Right heart catheterization indicated enormous coronary artery ectasia but normal PA pressures and wedge pressures. He was identified as a late presentation of Noonan’s syndrome on subsequent genetic testing. Discussion: Some series indicate a prevalence of 1 in 100 for mild Noonan’s syndrome phenotypes, highlighting the importance of understanding its cardiac presentations. In this case, we present a man with minimal symptoms but gross pathologies of his pulmonary and coronary arteries. Furthermore, pulmonary artery dilatation without pulmonary valve pathology has not been reported in the literature, and only a few reports of coronary artery ectasia are reported.
Influence of Bupyeong Samneung(三稜) and Sinchon(新村) on the Korean Popular Music History
Authors:   Institute For Kyeongki Cultural Studies, Jeong Yoo Chun
Published: January 2023

Under the Japanese colonialism the Incheon Army Arsenal was created in the Bupyeong area, and since Korea’s independence, this area was converted into a US military camp, forming a new modern urban landscape. The representative legacy created in this new modern urban landscape is Korean popular music that developed around the Samneung[三稜] and Sinchon[新村] in Bupyeong area. Although the popular music spaces of Bupyeong Samneung and Sinchon have a special and national meaning in the history of popular music in Korea, no full-scale research has been conducted. This study examines the formation process of Korean popular music space that appeared in the process of converting the Incheon Army Arsenal in the Bupyeong area into the US military camp since independence. The heritage value of the Incheon Army Arsenal can only be revealed when we look diachronically not only at the arsenal itself but also at the post-liberation landscape changes, and a plan to utilize it based on profound understanding can be sought.
Open data and algorithms for open science in AI-driven molecular informatics
Authors: Brinkhaus Henning Otto , Rajan Kohulan , Schaub Jonas , Zielesny Achim , Steinbeck Christoph
Published: January 2023

Recent years have seen a sharp increase in the development of deep learning and artificial intelligence-based molecular informatics. There has been a growing interest in applying deep learning to several subfields, including the digital transformation of synthetic chemistry, extraction of chemical information from the scientific literature, and AI in natural product-based drug discovery. The application of AI to molecular informatics is still constrained by the fact that most of the data used for training and testing deep learning models are not available as FAIR and open data. As open science practices continue to grow in popularity, initiatives which support FAIR and open data, as well as open-source software, have emerged. It is becoming increasingly important for researchers in the field of molecular informatics to embrace open science and to submit data and software in open repositories. With the advent of open-source deep learning frameworks and cloud computing platforms, academic researchers are now able to deploy and test their own deep learning models with ease. With the development of new and faster hardware for deep learning and the increasing number of initiatives towards digital research data management infrastructures, as well as a culture promoting open data, open source, and open science, AI-driven molecular informatics will continue to grow. This review examines the current state of open data and open algorithms in molecular informatics, as well as ways in which they could be improved in future.
Two-dimensional Antimonene as a promising candidate for Dioxin capture
Authors: Soliman Kamal , Meshhal Moyassar , Aziz Saadullah , Kühn Oliver , Shibl Mohamed
Published: January 2023

Among the serious environmental problems that attracted much attention from the broader public is the high toxicity of dioxins. Considerable efforts have been made to develop techniques and materials that could help in their efficient removal from the environment. Due to its high specific surface area and generous active sites, outstanding structural and electronic properties antimonene is considered for a variety of potential applications in different fields such as energy storage, electrocatalysis, and biomedicine. The present study adds to this portfolio by suggesting antimonene as a promising candidate for dioxin capture. Using density functional theory (DFT) calculations we studied the adsorption of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) on the pristine antimonene and Ca-, Ti-, and Ni-doped antimonene. Three configurations of the adsorption of TCDD on antimonene were analyzed. The results obtained from calculating adsorption energies, charge transfer, charge density differences, and densities of states (DOS) give evidence that antimonene outperforms the other nanomaterials that have been previously suggested for dioxin capture application. Therefore, we propose these substrates (i.e., pristine and doped antimonene) as potential capture agents for removing such toxic organic pollutants.
PETRO-MECHANICAL STUDIES OF THE STRATIGRAPHIC UNITS OF THE TARKWAIAN SUPERGROUP IN TARKWA – IMPLICATIONS FOR THE STRUCTURAL AND MECHANICAL COMPETENCE OF ROCKS
Authors: Wilson Matthew Coffie , Larbi Joseph , Kangah Isabella Ivy , Anison Enock
Published: January 2023

Main purpose of this paper is to determine the mineralogical composition and mechanical properties of the Tarkwaian Supergroup and compare them. This project will help determine whether the rock units of the Tarkwaian Supergroup are competent based on their mineral contents and strength of the rocks to be quarried and used as aggregates for construction and also determine the structural features that were formed in the various rock units due to the deformation that took place. Values obtained from the Unconfined Compressive Strength (UCS) test were (21.50-77.10) N/mm2 with the Kawere conglomerate having the lowest, and Tarkwa Phyllite having the highest strength. The Huni sandstone, Banket Quartzite and Kawere conglomerate were classified as weak rocks, but the Tarkwa Phyllite was classified as a medium rock, according to Attewell and Farmer’s (1976) classification. The Huni sandstone, Banket Quartzite and Kawere conglomerate are made up of grains of varying degrees of roundness and maturity. The Huni sandstone, Banket Quartzite, and Tarkwa Phyllite exhibit foliation. Micro-folding is also observed in the Kawere conglomerate. Petrographic studies of the rocks classify them as metasedimentary rocks weathering. Based on the weak strengths of the various rock units, they are not suitable to be used as aggregates for construction but can be used for other purposes such as construction sand and dimension stones.
EXPLORING NDVI AND NDBI RELATIONSHIP USING LANDSAT 8 OLI/TIRS IN KHANGARH TALUKA, GHOTKI
Authors: Ali Shah Shoukat , Kiran Madeeha , Nazir Aleena , Ashrafani Shaharyar Hassan
Published: January 2023

Built-up is one of the most significant type of land use-cover linked with urbanization. Computing, classifying, and mapping the built-up areas by Landsat image, is on priority demand for municipal and policymakers to investigate urban extension. Thus, increasing population and conversion of agricultural land into urban is a major topic understanding the bond between both types of land use. In the context of this, this study investigates the relationship between Normalized Difference Vegetation Index (NDVI) and Normalized Difference Built-up Index (NDBI) in Khangarh taluka. Therefore, satellite images of Landsat 8 OLI/TIRS 2014, 2016, 2018, and 2021 were downloaded freely from the USGS-GloVIS Earth Explorer website. The images were processed in the ArcGIS 10.3 environment. NDVI was calculated using the Near-Infrared NIR (band 5), Red (band 4) and for NDBI, Middle Infrared Reflectance MIR (band 6) and NIR (band 5) was used following the equation of both indices. The calculated values were then exported in SPSS software for correlation determination and scatter plot development. The results from the case showed that there was a linear and negative correlation between vegetation index and built-up index in all years over the study area. Furthermore, in 2014 the coefficient of correlation explicated R2=0.96; in 2016 R2=0.23, in 2018 R2=0.34, and in 2021 R2=0.22 which indicated that NDBI could be used to illustrate the evaluation of urban construction land. The all-over study recommends that built-up index NDBI not only can be used as a significant indicator for built-up or urban areas estimation but also deliver a consistent source for urban development and planning.
EFFECT OF COMPACTION AT DIFFERENT ENERGY LEVELS ON THE GEOTECHNICAL PROPERTIES OF STABILIZED SOILS
Authors: Ale Temitayo Olamide , Olofinyo Olabode Olabanji , Odebode Oluremi Success , Esan David Shola
Published: January 2023

This study is aimed at evaluating the influence of compaction (at different energy levels) on the geotechnical properties of stabilized soils. To achieve this, four bulk soil samples (BDL1, BDL2 BDL3 & BDT) consisting of termite reworked soils and residual lateritic soils were collected at New Stadium Road, Awo hall, University of Ibadan, Nigeria at a depth of 2m for strength tests and at depths of 1m, 1.5m & 2m for index tests. Geotechnical analysis (index tests and strength tests) and geochemical analysis (X-ray Diffraction) were carried out on the sampled soils. The study revealed that the mineral constituents of the sampled soils are quartz, kaolinite and hematite; with the termite-reworked soil richer in kaolinite content than the quartz schist derived soil with about 125% increase. The values of index tests for both soils met the required Nigeria specification for good soil with termite reworked soil performing better. The values of specific gravity for both soils are close suggesting similar origin. AASHTO classification put termite-reworked soil within the range of A-2-7 (good rating) while most of the residual soil samples fall within A-7-5 to A-7-6 range (fair to poor rating). The stabilisation of residual lateritic soil using termite-reworked soil as stabiliser brought about increase in the values of maximum dry density, uncured unconfined compressive strength as well as the sun-cured unconfined compressive strength of the studied soil. The influence of stabilisation using termite-reworked soil was strongest at the highest level of compaction ((30%) of termite-reworked soil with the weight of residual soil). There also exist a fairly strong positive correlation between the amount of termite reworked soil and energy of compaction and between the uncured and sun-cured unconfined compressive strength was plotted against the number of blows for BDL1, BDL2 and BDL3 respectively. In sum, these stabilised soils are suitable for foundation and landfills materials.
STRUCTURES OF BIRIMIAN AND TARKWAIAN ROCKS AT NORTH-WEST NEW DROBO – IMPLICATION ON DEFORMATION
Authors: Wilson Matthew Coffie , Amedjoe Chiri G. , Gawu Simon K. Y.
Published: January 2023

This research leads to identifying the microstructures, the deformation episodes (D) and foliation grades (S) of rocks in the study area. Different geological structures such as shear zones, foliations, micro-faults, crack-seal events, etc. have been identified in the study area. Different phases of deformation episodes and foliation grades have been studied to determine the deformation environments. Senses of shear such as dextral, CS, and CS’ as well as antithetic and synthetic micro-faults and boudins may be identified at the north-west New Drobo. Three (3) main deformational (D) events and foliation grades (S) in both the Tarkwaian sandstones and Birimian volcanic rocks may be identified as D1, D2 and D3 as well as S1, S2 and S3. Recrystallization of quartz and feldspar through bulging (BLG), subgrain boundary rotation (SBR) and grain boundary migration (GBM) have been observed at the study area. The overprinting relationships in the Birimian Supergroup may be identified with three (3) different deformational phases. The first deformation (D1) defines the formation of a vertical shortening, whilst the second deformation (D2) defines oblique shortening. Moreover, the third deformation (D3) is due to high strain rate causing brittle faulting.
Functional substitutions of amino acids that differ between GDF11 and GDF8 impact skeletal development and skeletal muscle
Authors: Lian John , Walker Ryan G , D’Amico Andrea , Vujic Ana , Mills Melanie J , Messemer Kathleen A , Mendello Kourtney R , Goldstein Jill M , Leacock Krystynne A , Epp Soraya , Stimpfl Emma V , Thompson Thomas B , Wagers Amy J , Lee Richard T
Published: January 2023

Growth differentiation factor 11 (GDF11) and GDF8 (MSTN) are closely related TGF-β family proteins that interact with nearly identical signaling receptors and antagonists. However, GDF11 appears to activate SMAD2/3 more potently than GDF8 in vitro and in vivo. The ligands possess divergent structural properties, whereby substituting unique GDF11 amino acids into GDF8 enhanced the activity of the resulting chimeric GDF8. We investigated potentially distinct endogenous activities of GDF11 and GDF8 in vivo by genetically modifying their mature signaling domains. Full recoding of GDF8 to that of GDF11 yielded mice lacking GDF8, with GDF11 levels ∼50-fold higher than normal, and exhibiting modestly decreased muscle mass, with no apparent negative impacts on health or survival. Substitution of two specific amino acids in the fingertip region of GDF11 with the corresponding GDF8 residues resulted in prenatal axial skeletal transformations, consistent withGdf11-deficient mice, without apparent perturbation of skeletal or cardiac muscle development or homeostasis. These experiments uncover distinctive features between the GDF11 and GDF8 mature domains in vivo and identify a specific requirement for GDF11 in early-stage skeletal development.
Landscape-Forming Processes, Factors and Landscape Structure of the South of the Selenga Middle Mountains
Authors:   V. B. Sochava Institute of Geography SB RAS, Frolov A. A.
Published: January 2023

The article studies the landscape structure of the territory of south the Selenga middle mountains. The introduction to the article defines the concepts of landscape structure, factor-dynamic system, and reveals the essence of the structural-dynamic approach to the study of geosystems. The section "Object and methods of research" describes the natural conditions of the south of the Selenga middle mountains and methods of landscape research. The results of the study present an analysis of the main landscape-forming processes, factor-dynamic series, and dynamic categories of geosystems, as well as a map of the landscape structure of the study area. A structural-dynamic (factor-dynamic) approach to the analysis of landscape structure was implemented using GIS technologies based on remote sensing data, field research materials, maps of various contents and literary information. The leading landscape-forming processes and the main factors that influence the formation of the landscape structure are shown. As a result of the conducted research, a landscape map of geosystems of the topological hierarchical level was constructed, which shows the types of geosystems (geomes, classes and groups of facies) reflecting the factor-dynamic structure of landscapes. For the mountains of the south of the Selenga Middle Mountains, the leading landscape-forming processes are gravity-slope, slope water-erosion, fluvial and aeolian processes that determine the formation of lithomorphic, alluvial-hydrolithomorphic and psammo-lithomorphic factorial-dynamic series of geosystems (facies classes). For plains, the leading landscape-forming processes are slope water-erosion, alluvial, lacustrine and aeolian, forming lithomorphic, alluvial-hydromorphic and psammomorphic series of facies.
Formation, Development and Prospects of the Recreation Industry on the Territory of Yuzhno-Minusinskaya Depression
Authors:   V. B. Sochava Institute of Geography SB RAS, Balyazin I. V.
Published: January 2023

This paper discusses the features of the development of the recreational industry in the Central Asian region of Russia, using the example of the Yuzhno-Minusinskaya depression. Current trends in the global economy are associated with the closure of borders, redirecting tourist flows inland. The development of this industry in recent years has been eco-centric. Therefore, the involvement of specially protected natural areas (SPNA) in this activity has become a necessary step, allowing not only to help in preserving the environment, but also to instill a respect for nature. With the well-coordinated work of local travel agencies, the administration and the population, it is possible to most effectively fill and diversify the rest for visiting tourists, to ensure a high educational interest in the cultural and natural values of the region, and with a high level of development of transport infrastructure, collective accommodation facilities and competent elaboration of routes, make the region attractive to tourists.mass tourism throughout the year. The historical heritage inherited by the study area from the middle of the 20th century has become the basis for the modern development of the recreational industry. At the same time, new types of tourism are developing very quickly and effectively, and thus make the rest even more intense and interesting. By combining all the information into a common spatial model, you can move on to a higher rank of research activity – forecasting and planning, for which, in our opinion, it is most convenient to use cartographic constructions
A Prospective Meta-Analysis (PMA) Could Harmonize the Studies Focusing on Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA)
Authors: Taghrir Mohammad Hossein , Borazjani Roham , McGreevy David , Paydar Shahram , Mohseni Shahin
Published: January 2023

With the rapid development of novel surgical devices such as Resuscitative Endovascular Balloon Occlusion of theAorta (REBOA) and the eagerness of clinicians to use them, there is a risk that their usage in clinical practice exceedsthe evidence-based principles required for their introduction. This might be truer in the fields, such as trauma surgery,where the patient population and the disease (injury) burden are very heterogeneous and time-sensitive, and thus not fitting for the more gold standard investigation methods. The studies that are currently being published considering the use of REBOA in clinical settings have significant limitations and raise concerns in terms of the risk of biases that might influence the gold-standard evidence-based synthesis. This paper elaborates on the merits of a Prospective Meta-Analysis (PMA) in reducing such biases.
Pengembangan Media Pembelajaran Wayang Karakter Muslim pada Mata Pelajaran Pendidikan Kewarganegaran di MIN 3 Jombang
Authors: Yulia Nurul Mahruzah , Fithriyah Dewi Niswatul
Published: January 2023

Pengenalan perilaku sesuai nilai-nilai Pancasila harus diupayakan sejak dini, yakni di tingkat Pendidikan Dasar. Agar sikap peduli, kerjasama, dan penghormatan antara sesama manusia dapat terintegrasi secara kuat di diri peserta didik. Di samping itu, pengenalan budaya lokal juga menjadi hal yang urgent, agar anak dapat lebih mencintai budayanya sendiri. Penelitian ini merupakan penelitian berjenis Research and Development, dengan menggunakan model pengembangan ADDIE yang memiliki 5 tahapan utama. Penelitian dan pengembangan ini melibatkan berbagai ahli, yakni ahli media dan ahli pembelajaran. Pengumpulan  data yang digunakan dalam penelitian ini di antaranya wawancara, observasi, angket, dan tes, yang disusun khusus sesuai teori-teori pengembangan media pembelajaran dan materi Pendidikan Kewarganegaraan kelas 1 MI. Hasil pengembangan ini menunjukkan bahwa uji validasi materi sebesar 90%, validasi desai sebesar 95%, dan Uji Coba Lapangan 94,4%. Rata-rata pretest dan posttest juga mengalami kenaikan dengan hasil pre-test sebesar 60,4 dan rata-rata post-test sebesar 85,6. Hal ini menunjukkan bahwa media yang dikembangkan dapat dikatakan valid dan dapat digunakan dalam pembelajaran Pendidikan Kewarganegaraan.
Penerapan Model Paikem pada Pembelajaran PAI dalam Meningkatkan Minat Belajar Siswa Kelas IV di SDN 61 Karara Kota Bima
Authors: Trimansyah Trimansyah , Rosmiati
Published: January 2023

Penelitian ini untuk mengetahui penerapan model pembelajaran PAIKEM pada pembelajaran PAI sebagai model pembelajaran yang dapat meningkatkan minat belajar siswa.Jenis yang digunakan dalam penelitian ini yaitu jenis penelitian kualitatif dengan pendekatan deskriptif, pengumpulan data menggunakan model wawancara, observasi dan dokumentasi. Dengan analisis penelitian dimulai dengan pengumpulan data, mereduksi data, display data dan menyimpulkan. Hasil proses belajar mengajar pada mata pelajaran PAI di Sekolah Dasar dengan menggunakan model PAIKEM menunjukkan hasil yang maksimal dan baik. Hal ini ditandai dengan adanya perubahan sikap, tingkah laku dan emosional peserta didik misalnya, sebelum masuk kelas mereka pandai dalam membawa salam, ketika bertemu guru, sesama siswa dan siapapun yang ditemui selalu berjabat dan mencium tangan, dalam keseharian sudah menampilkan sikap sopan dan santun serta nurut dalam bergaul dengan sesama siswa maupun dengan guru. Hal ini merupakan hasil yang sangat signifikan setelah menerapkan model PAIKEM pada setiap proses pembelajaran yang dilihat ada peningkatan sikap dan perubahan dari yang sebelumnya.
Pengembangan LKPD Online Tingkat SD yang Terintegrasi Langsung dengan Sistem Pengerjaan dan Penilaian
Authors: Dicky Anggriawan Nugroho
Published: January 2023

Penelitian ini bertujuan untuk mengembangkan media pembelajaran online berbasis Lembar Kerja Peserta Didik (LKPD) yang dapat diakses secara online dan terintegrasi langsung dengan sistem pengerjaan serta sistem penilaian. Penelitian berbasis penelitian dan pengembangan (R&D) dengan metode pengembangan model 4D. Subjek dari penelitian ini adalah para ahli yang bertempat SDN 03 Gejlig yang terdiri dari ahli media pembelajaran, ahli materi dan peserta didik kelas 6 SD. Penelitian dimulai dengan cara pengumpulan data berdasarkan hasil wawancara dan observasi langsung, survei mengenai media dari ahli media pembelajaran, survei mengenai materi dari ahli materi pembelajaran, dan survei mengenai motivasi belajar peserta didik menggunakan Google Form untuk mendapatkan hasil yang mudah dianalisa. Untuk teknik analisis data menggunakan analisis deskriptif kuantitatif dan uji hipotesis menggunakan regresi linier sederhana. Dan hasil dari analisa mendapatkan hasil bahwa media pembelajaran berbasis Lembar Kerja Peserta Didik Online Tingkat SD ini sangat layak untuk dikembangkan dan diterapkan karena keefektifannya dalam mempengaruhi motivasi peserta didik dan memudahkan sistem penilaian dan pengerjaan LKPD online.
GƏNC FUTBOLÇULARIN TEXNİKİ USTALIQLARININ FORMALAŞDIRILMASINDA BİOMEXANİKİ GÖSTƏRİCİLƏRİN DİNAMİKASININ VELOERQOMETRİK ÜSULLA TƏDQİQİ
Authors: K.S.Mammadova  , Sh.Ch. Jafarova
Published: January 2023

Gənc futbolçuların texniki ustalıqlarının formalaşdırılmasında biomexaniki göstəricilərin dinamikasının veloerqometrik üsulla tədqiqi araşdırılmışdır. Futbol hərəkət və aktivlik baxımından mürəkkəb texniki oyun növüdür. 15-22 yaş qrupuna aid olan gənc futbolçuların texniki ustalıqlarının formalaşmasına təsir göstərən biomexaniki göstəricilərin yenidən ölçülməsi üçün İnBody və Veloerqometr cihazlarında xüsusi  yüklənmələr nəzərdə tutulmaqla, ölçmələrin aparılması həyata keçirilmişdir. 15-22 yaş qrupuna aid olan gənc futbolçuların texniki ustalıqlarının formalaşmasına təsir göstərən biomexaniki göstəricilərin strukturunun təhlili göstərdi ki, gənc futbolçularda dözümlülük, cəldlik 15-18 yaş arası qruplarda artır, 18-22 yaş arası qruplarda cüzi artır və ya azalır. Başlanğıc hərəkətlərin təşkilinin mürəkkəbliyi onunla bağlıdır ki, bir hərəki koordinasiyadan digərinə keçərkən hərəkətlər bir-birinə əsaslanır. Ona görə də biomexaniki göstəricilərin dəyişməsi həssas dövrdə deyil, çoxillik davamlı məşqlərin nəticəsində mümkündür.
GENDER EQUALITY IN HUMAN RESOURCES MANAGEMENT. A CASE STUDY OF THE SHOOTING FEDERATION OF AZERBAIJAN
Authors: L.U. Gurbanova
Published: January 2023

The concept "gender equality" is now gaining prominence around the world in sport and sport-related areas, becoming an important and critical part of Human Resources Management (further: HRM). Gender equality is considered one of the fundamental values of good governance in sports organizations and achieving it has been one of the most important recent trends in most sports organizations. Equality at an elite level has an impact on sports organizations as it offers female role models to aspire to. This research project could serve as an example to be transferred to other sports federations by taking the shooting sport and the Azerbaijan Shooting Federation as a case study.
ВЛИЯНИЕ СТРЕССА НА ОРГАНИЗМ СПОРТСМЕНОВ
Authors: A.K. Hasanova  , N.T. Asadullayeva  , G.M. Behbudova
Published: January 2023

Рекорды, к которым стремятся все спорт­смены, невозможны не только без дли­тельных всевозрастающих тренировочных нагрузок, но и без кратковременного макси­маль­ного напря­жения всех физических и эмоциональных резер­вов организма в период основного выступления. Последнее реализуется через состояние, кото­рое привычно обозна­чается как "стресс”. Механизм развития стресса уни­версален, не зави­­сит от причин, его вызывающих - будь то желание достичь цели любой ценой, трав­ма мозга или хирургическая агрессия. Так что, тренировки позво­ляют повышать не только физическую выносливость и мышечную си­лу, но и эмоциональную устойчивость. Именно поэтому, правильная подго­товка перед состя­за­нием позволяет нивелировать патологические послед­ствия стресса.
RELEVANT TASKS OF OLYMPIC EDUCATION IN THE MODERN OLYMPIC MOVEMENT
Authors: N.Y. Melnikova  , V.I. Stolyarov  , M.V. Koreneva  , V.V.Melnikov
Published: January 2023

This article is devoted to the relevant tasks of Olympic education in the modern Olympic Movement. The set of complex social and pedagogical problems, such as a complete rejection of the humanistic ideals of Pierre de Coubertin in his concept of Olympism, unfair competitions, the decline in youth interest in the Olympic Games and others, as well as the ways to promote Olympic values have been presented in the article.
ПЕДАГОГИЧЕСКИЕ ОСОБЕННОСТИ РАЗВИТИЯ ОЛИМПИЙСКОГО ДВИЖЕНИЯ В СОВРЕМЕННОМ АЗЕРБАЙДЖАНЕ
Authors: A.R. Aliyeva
Published: January 2023

В статье рассматривается вопрос - педагогические особенности развития Олимпийского движения в современном Азербайджане. Олимпийское движение становится все более популярным в цивилизованном мире, благодаря сближению национальных культур, взаимопониманию и дружелюбному отношению людей разных стран. Oлимпийское движение является целостной социально-педагогической системой, находящейся во взаимодействии с культурой, экономикой, здравоохранением и иными отраслями. В статье анализируются особенности развития различных видов спорта в Азербайджане, основные принципы проведения Олимпийских игр, важность участия молодежи и школьников в международных спортивных соревнованиях, цели Олимпийского движения, применение инноваций в олимпийском образовании.
DİSPERSİYA VƏ KORRELYASİYA ANALİZİ VASİTƏSİYLƏ CARİ NƏZARƏT TESTLƏRİNİN ETİBARLIĞININ QİYMƏTLƏNDİRİLMƏSİ
Authors: N.M. Kalantarli  , T.Q. Abiyev
Published: January 2023

Məqalə məşq yüklərinin planlaşdırılması üçün vacib olan informasiyanın toplanması və təhlilinə xidmət edən cari nəzarət testlərinin informativliyinin və etibarlığının riyazi-statistik üsullarla qiymətləndirilməsinə həsr edilib. Məşq mikrotsiklində yüklərin tənzimlənməsi məqsədiylə real və planlaşdırılan məşq effektlərinin müqayisə olunma sxemi təhlil edilmişdir. Dispersiya analizinin verilənlərin korrelyasiyasını nəzərə alan üsulunun hesablama modeli əsasında Turbo-Paskal dilində tərtib olunmuş komputer proqramı vasitəsiylə cari nəzarət testlərinin autentliyi təyin edilmişdir.
İDMANIN TƏKMÜBARİZLİK NÖVLƏRİNİN İNKİŞAF STRATEGİYASINA MÜASİR BAXIŞ
Authors: G.Sh. Abiyev
Published: January 2023

İdmanın təkmübarizlik növlərinin inkişaf strategiyası idmanın kütləviliyi və sistemli inkişafını özündə birləşdirən kompleks tədbirləri əhatə edir. Strategiya idmanın sistemli inkişafının məqsəd və vəzifələri, perspektiv mərhələləri, prioritet istiqamətlərini müəyyənləşdirir və bu yönümlü proqram, kompleks tədbirlərin işlənilməsi üçün əsasdır. Son illər idmanın təkmübarizlik növlərinin inkişafında müşahidə edilən problemlər yeni yanaşmalar və müasir innovativ metodların kompleks tətbiqini tələb edir.
“WORLD REVOLUTION” ON THE ОUTSKIRTS OF THE BRITISH EMPIRE IN THE SECOND HALF OF THE 1920’S. MYTH OR REALITY?
Authors:   Russian Academy of Sciences Institute of World History, Sergeev Evgeny Yu.
Published: January 2023

Based upon the wide range of sources, including Russian and British archival documents, published diplomatic correspondence, diaries penned by some eye-witnesses and newspaper commentaries, the article dwells upon the attempts by the Comintern to bring to life the ideas of “world revolution” in the Middle East states – such as Persia and Afghanistan, as well as in the Chinese possessions – Sinkiang and Tibet, which in the period under review – the second half of the 1920s, gained a quasi-independent status. The author meticulously examines various forms and methods of exporting revolutionary practices to the British Empire Asian outskirts, where Indian subcontinent occupied a key position. As a result of the study, it was established that by the beginning of the 1930s, the concept of the “world revolution” as one of the directions of Soviet foreign policy underwent a transformation from reality into a myth, which began to perform mainly propaganda functions. Besides that, the author came to conclusion that the transformation had a serious impact on the development of Soviet-Britain relations during the second conservative government of S. Baldwin, being zigzag in nature – from the state of mutual confrontation in 1925–1926, through the rupture of 1927, to the restoration after the return to power of the Labour Party in 1929.
ARCTIC POLICY OF THE CONSERVATIVE AND LIBERAL GOVERNMENT OF CANADA IN 1993–2011
Authors:   Russian State University for the Humanities, Kasenkov Vasilii I.
Published: January 2023

This article discusses the Arctic agenda of the liberal and conservative cabinets of J. Chretien and S. Harper. Attention is also paid to the short period of P. Martin’s premiership. The author consistently considers the position of liberals based on the desire for international cooperation and the solution of common problems of the region. The head of the liberal Party, J. Chretien, sought cooperation with all the Arctic states; in particular, he repeatedly visited Russia on official visits. Prime Minister of the Conservative party S. Harper did not visit the Russian Federation, but made traditional visits to the Arctic, where he made policy statements. In contrast to the position of the liberals, the conservatives relied on the buildup of military power, thus seeking to strengthen their positions in the Arctic and on the world stage. In the future, events both inside and outside the country have led to the fact that the conservative position regarding the Arctic region has undergone some changes. On the eve of the 2011 parliamentary elections, the Conservatives retreated from the one-sided position of expanding military forces and began to pay attention to other problems in the region, among other things. The purpose of this article is to compare the political actions of the Conservative and Liberal parties of Canada in the Arctic. Despite the fact that there are separate studies of the political actions of both representatives of liberals and conservatives, the novelty of this article lies in comparing these different approaches over a certain period of time.