bluuebunny/crossref_metadata_2025 huggingface dataset:
Integrin-Targeting Dye-Doped PEG-Shell/Silica-Core Nanoparticles Mimicking the Proapoptotic Smac/DIABLO Protein
Authors: De Marco Rossella , Rampazzo Enrico , Zhao Junwei , Prodi Luca , Paolillo Mayra , Picchetti Pierre , Gallo Francesca , Calonghi Natalia , Gentilucci Luca
Published: June 2020

Cancer cells demonstrate elevated expression levels of the inhibitor of apoptosis proteins (IAPs), contributing to tumor cell survival, disease progression, chemo-resistance, and poor prognosis. Smac/DIABLO is a mitochondrial protein that promotes apoptosis by neutralizing members of the IAP family. Herein, we describe the preparation and in vitro validation of a synthetic mimic of Smac/DIABLO, based on fluorescent polyethylene glycol (PEG)-coated silica-core nanoparticles (NPs) carrying a Smac/DIABLO-derived pro-apoptotic peptide and a tumor-homing integrin peptide ligand. At low μM concentration, the NPs showed significant toxicity towards A549, U373, and HeLa cancer cells and modest toxicity towards other integrin-expressing cells, correlated with integrin-mediated cell uptake and consequent highly increased levels of apoptotic activity, without perturbing cells not expressing the α5 integrin subunit.
Solid Plasmonic Substrates for Breast Cancer Detection by Means of SERS Analysis of Blood Plasma
Authors: Știufiuc Gabriela Fabiola , Toma Valentin , Buse Mihail , Mărginean Radu , Morar-Bolba Gabriela , Culic Bogdan , Tetean Romulus , Leopold Nicolae , Pavel Ioana , Lucaciu Constantin Mihai , Știufiuc Rareș Ionuț
Published: June 2020

Surface enhanced Raman spectroscopy (SERS) represents a promising technique in providing specific molecular information that could have a major impact in biomedical applications, such as early cancer detection. SERS requires the presence of a suitable plasmonic substrate that can generate enhanced and reproducible diagnostic relevant spectra. In this paper, we propose a new approach for the synthesis of such a substrate, by using concentrated silver nanoparticles purified using the Tangential Flow Filtration method. The capacity of our substrates to generate reproducible and enhanced Raman signals, in a manner that can allow cancer detection by means of Multivariate Analysis (MVA) of Surface Enhanced Raman (SER) spectra, has been tested on blood plasma samples collected from 35 healthy donors and 29 breast cancer patients. All the spectra were analyzed by a combined Principal Component-Linear Discriminant Analysis. Our results facilitated the discrimination between healthy donors and breast cancer patients with 90% sensitivity, 89% specificity and 89% accuracy. This is a direct consequence of substrates’ ability to generate diagnostic relevant spectral information by performing SERS measurements on pristine blood plasma samples. Our results suggest that this type of solid substrate could be employed for the detection of other types of cancer or other diseases by means of MVA-SERS procedure.
Effect of Nano-Reinforcement Topologies on the Viscoelastic Performance of Carbon Nanotube/Carbon Fiber Hybrid Composites
Authors: Ayyagari Suma , Al-Haik Marwan , Ren Yixin , Nepal Dhriti
Published: June 2020

In this investigation, multi-walled carbon nanotubes (MWCNTs) were grown over carbon fiber fabrics via a relatively nondestructive synthesis technique. The MWCNTs patches were grown into three different topologies: uniform, fine patterned and coarse patterned. Hybrid carbon fiber-reinforced polymer composites (CFRPs) were fabricated based on the patterned reinforcements. Tensile tests, dynamic mechanical thermal analyses (DMTA) and flexure load relaxation tests were carried out to investigate the effect of the patterned nano-reinforcement on the static, dynamic, glass transition, and viscoelastic performance of the hybrid composites. Results revealed that the hybrid composite based on fine-patterned topology achieved better performance over all other configurations as it exhibited about 19% improvement in both the strength and modulus over the reference composite with no MWCNTs. Additionally, the increase in glass transition for this composite was as high as 13%. The damping parameter (tan δ) was improved by 46%. The stress relaxation results underlined the importance of patterned MWCNTs in minimizing the stress decay at elevated temperatures and loading conditions. Utilizing patterned MWCNTs topology significantly reduced the stress decay percentage at the thermomechanical conditions 60 MPa and 75 °C from 16.7% to 7.8%. These improvements are attributed to both the enhanced adhesion and large interface area by placing MWCNTs and by inducing an interlocking mechanism that allows the interaction of the three constituents in load transfer, crack deflection and hindering undesired viscoelastic deformations under different thermomechanical loadings.
Health Effects of Coffee: Mechanism Unraveled?
Authors: Kolb Hubert , Kempf Kerstin , Martin Stephan
Published: June 2020

The association of habitual coffee consumption with a lower risk of diseases, like type 2 diabetes mellitus, chronic liver disease, certain cancer types, or with reduced all-cause mortality, has been confirmed in prospective cohort studies in many regions of the world. The molecular mechanism is still unresolved. The radical-scavenging and anti-inflammatory activity of coffee constituents is too weak to account for such effects. We argue here that coffee as a plant food has similar beneficial properties to many vegetables and fruits. Recent studies have identified a health promoting mechanism common to coffee, vegetables and fruits, i.e., the activation of an adaptive cellular response characterized by the upregulation of proteins involved in cell protection, notably antioxidant, detoxifying and repair enzymes. Key to this response is the activation of the Nrf2 (Nuclear factor erythroid 2-related factor-2) system by phenolic phytochemicals, which induces the expression of cell defense genes. Coffee plays a dominant role in that regard because it is the major dietary source of phenolic acids and polyphenols in the developed world. A possible supportive action may be the modulation of the gut microbiota by non-digested prebiotic constituents of coffee, but the available data are still scarce. We conclude that coffee employs similar pathways of promoting health as assumed for other vegetables and fruits. Coffee beans may be viewed as healthy vegetable food and a main supplier of dietary phenolic phytochemicals.
Complementary Feeding in Preterm Infants: A Systematic Review
Authors: Liotto Nadia , Cresi Francesco , Beghetti Isadora , Roggero Paola , Menis Camilla , Corvaglia Luigi , Mosca Fabio , Aceti Arianna ,   on behalf of the Study Group on Neonatal Nutrition and Gastroenterology—Italian Society of Neonatology
Published: June 2020

Background: This systematic review summarizes available literature regarding complementary feeding (CF) in preterm infants, with or without comorbidities that may interfere with oral functions. Methods: A literature search was conducted in PubMed and the Cochrane Library. Studies relating to preterm infants (gestational age <37 weeks) were included in the analysis. Retrieved papers were categorized according to their main topic: CF timing and quality; clinical outcome; recommendations; strategies in infants with oral dysfunction. Results: The literature search in PubMed retrieved 6295 papers. Forty met inclusion criteria. The Cochrane search identified four additional study protocols, two related to studies included among PubMed search results, and two ongoing trials. Moreover, among 112 papers dealing with oral feeding, four aiming at managing CF in preterm infants with oral dysfunctions were identified. Conclusions: The available literature does not provide specific guidelines on the management of CF in preterm infants, who are generally weaned earlier than term infants. There is a paucity of data regarding the relationship between CF and growth/quality of growth and health outcomes in preterm infants. It could be suggested to start CF between five and eight months of chronological age if infants have reached three months corrected age and if they have acquired the necessary developmental skills. An individualized multidisciplinary intervention is advisable for preterm infants with oral dysfunctions.
Dietary n-6/n-3 Ratio Influences Brain Fatty Acid Composition in Adult Rats
Authors: Horman Thomas , Fernandes Maria F. , Tache Maria C. , Hucik Barbora , Mutch David M. , Leri Francesco
Published: June 2020

There is mounting evidence that diets supplemented with polyunsaturated fatty acids (PUFA) can impact brain biology and functions. This study investigated whether moderately high-fat diets differing in n-6/n-3 fatty acid ratio could impact fatty acid composition in regions of the brain linked to various psychopathologies. Adult male Sprague Dawley rats consumed isocaloric diets (35% kcal from fat) containing different ratios of linoleic acid (n-6) and alpha-linolenic acid (n-3) for 2 months. It was found that the profiles of PUFA in the prefrontal cortex, hippocampus, and hypothalamus reflected the fatty acid composition of the diet. In addition, region-specific changes in saturated fatty acids and monounsaturated fatty acids were detected in the hypothalamus, but not in the hippocampus or prefrontal cortex. This study in adult rats demonstrates that fatty acid remodeling in the brain by diet can occur within months and provides additional evidence for the suggestion that diet could impact mental health.
Molecules from American Ginseng Suppress Colitis through Nuclear Factor Erythroid-2-Related Factor 2
Authors: Chaparala Anusha , Tashkandi Hossam , Chumanevich Alexander A. , Witalison Erin E. , Windust Anthony , Cui Taixing , Nagarkatti Mitzi , Nagarkatti Prakash , Hofseth Lorne J.
Published: June 2020

Ulcerative colitis (UC) is a chronic inflammatory bowel disease that affects millions of people worldwide and increases the risk of colorectal cancer (CRC) development. We have previously shown that American ginseng (AG) can treat colitis and prevent colon cancer in mice. We further fractionated AG and identified the most potent fraction, hexane fraction (HAG), and the most potent compound in this fraction, panaxynol (PA). Because (1) oxidative stress plays a significant role in the pathogenesis of colitis and associated CRC and (2) nuclear factor erythroid-2-related factor 2 (Nrf2) is the master regulator of antioxidant responses, we examined the role of Nrf2 as a mechanism by which AG suppresses colitis. Through a series of in vitro and in vivo Nrf2 knockout mouse experiments, we found that AG and its components activate the Nrf2 pathway and decrease the oxidative stress in macrophages (mΦ) and colon epithelial cells in vitro. Consistent with these in vitro results, the Nrf2 pathway is activated by AG and its components in vivo, and Nrf2-/- mice are resistant to the suppressive effects of AG, HAG and PA on colitis. Results from this study establish Nrf2 as a mediator of AG and its components in the treatment of colitis.
Mori Cortex Radicis Attenuates High Fat Diet-Induced Cognitive Impairment via an IRS/Akt Signaling Pathway
Authors: You SoHyeon , Jang Miran , Kim Gun-Hee
Published: June 2020

Present study was conducted to investigate ameliorating effects of Mori Cortex radicis on cognitive impair and neuronal defects in HFD-induced (High Fat Diet-Induced) obese mice. To induce obesity, C57BL/6 mice were fed an HFD for 8 weeks, and then mice were fed the HFD plus Mori Cortex radicis extract (MCR) (100 or 200 mg/kg/day) for 6 weeks. Prior to sacrifice, body weights were measured, and Y-maze test and oral glucose tolerance test were performed. Serum lipid metabolic biomarkers (TG, LDL, and HDL/total cholesterol ratio) and antioxidant enzymes (glutathione, superoxide dismutase, and catalase), malondialdehyde (MDA), and acetylcholinesterase (AChE) levels were measured in brain tissues. The expressions of proteins related to insulin signaling (p-IRS, PI3K, p-Akt, and GLUT4) and neuronal protection (p-Tau, Bcl-2, and Bax) were examined. MCR suppressed weight gain, improved serum lipid metabolic biomarker and glucose tolerance, inhibited AChE levels and MDA production, and restored antioxidant enzyme levels in brain tissue. In addition, MCR induced neuronal protective effects by inhibiting p-Tau expression and increasing Bcl-2/Bax ratio, which was attributed to insulin-induced increases in the expressions p-IRS, PI3K, p-Akt, and GLUT4. These indicate MCR may reduce HFD-induced insulin dysfunction and neuronal damage and suggest MCR be considered a functional material for the prevention of T2DM-associated neuronal disease.
New Insights in Preterm Nutrition
Authors: Roggero Paola , Liotto Nadia , Menis Camilla , Mosca Fabio
Published: June 2020

Nutrition of preterm infants has a crucial role in the promotion of organ’s optimal growth and development [...]
Ocular Co-Delivery of Timolol and Brimonidine from a Self-Assembling Peptide Hydrogel for the Treatment of Glaucoma: In Vitro and Ex Vivo Evaluation
Authors: Taka Elissavet , Karavasili Christina , Bouropoulos Nikolaos , Moschakis Thomas , Andreadis Dimitrios D. , Zacharis Constantinos K. , Fatouros Dimitrios G.
Published: June 2020

Effective pharmacotherapy during glaucoma treatment depends on interventions that reduce intraocular pressure (IOP) and retain the IOP lowering effect for sufficient time so as to reduce dosing frequency and enhance patient adherence. Combination anti-glaucoma therapy and dosage forms that increase precorneal residence time could therefore constitute a promising therapeutic intervention. The in-situ gel forming self-assembling peptide ac-(RADA)4-CONH2 was evaluated as carrier for the ocular co-delivery of timolol maleate (TM) and brimonidine tartrate (BR). The hydrogel’s microstructure and mechanical properties were assessed with atomic force microscopy and rheology, respectively. Drug diffusion from the hydrogel was evaluated in vitro in simulated tear fluid and ex vivo across porcine corneas and its effect on the treated corneas was assessed through physicochemical characterization and histological analysis. Results indicated that TM and BR co-delivery affected hydrogel’s microstructure resulting in shorter nanofibers and a less rigid hydrogel matrix. Rapid and complete release of both drugs was achieved within 8 h, while a 2.8-fold and 5.4-fold higher corneal permeability was achieved for TM and BR, respectively. No significant alterations were induced in the structural integrity of the corneas treated with the hydrogel formulation, suggesting that self-assembling peptide hydrogels might serve as promising systems for combination anti-glaucoma therapy.
The Impact of Religion and National Origin on Attitudes towards Refugee Rights: An International Comparative Empirical Study
Authors: Unser Alexander , Ziebertz Hans-Georg
Published: June 2020

This paper is concerned with the rights of refugees. The refugee issue has been an acutely charged item on the political agenda for several years. Although the great waves of influx have flattened out, people are continually venturing into Europe. Europe’s handling of refugees has been subject to strong criticism, and the accusation that various actions contradict internationally agreed law is particularly serious. It remains a question of how to respond appropriately to the influx of people fearing for their lives. This paper examines empirically how young people from different denominations in Germany (n = 2022) and how Roman Catholics from 10 countries (n = 5363) evaluate refugee rights. It also investigates whether individual religiosity moderates the influence of denomination or national context. The results show that there are no significant differences between respondents from different denominations, but there are significant differences between respondents from different countries. However, religiosity was not found to moderate the influence of denomination or national context. These findings suggest that attitudes towards refugee rights depend more on the national context in which people live rather than on their religious affiliation or individual religiosity.
Dry Panels Supporting External Quality Assessment Programs for Next Generation Sequencing-Based HIV Drug Resistance Testing
Authors: Noguera-Julian Marc , Lee Emma R. , Shafer Robert W. , Kantor Rami , Ji Hezhao
Published: June 2020

External quality assessment (EQA) is a keystone element in the validation and implementation of next generation sequencing (NGS)-based HIV drug resistance testing (DRT). Software validation and evaluation is a critical element in NGS EQA programs. While the development, sharing, and adoption of wet lab protocols is coupled with the increasing access to NGS technology worldwide, rendering it easy to produce NGS data for HIV-DRT, bioinformatic data analysis remains a bottleneck for most of the diagnostic laboratories. Several computational tools have been made available, via free or commercial sources, to automate the conversion of raw NGS data into an actionable clinical report. Although different software platforms yield equivalent results when identical raw NGS datasets are analyzed for variations at higher abundance, discrepancies arise when variations at lower frequencies are considered. This implies that validation and performance assessment of the bioinformatics tools applied in NGS HIV-DRT is critical, and the origins of the observed discrepancies should be determined. Well-characterized reference NGS datasets with ground truth on the genotype composition at all examined loci and the exact frequencies of HIV variations they may harbor, so-called dry panels, would be essential in such cases. The strategic design and construction of such panels are challenging but imperative tasks in support of EQA programs for NGS-based HIV-DRT and the validation of relevant bioinformatics tools. Here, we present criteria that can guide the design of such dry panels, which were discussed in the Second International Winnipeg Symposium themed for EQA strategies for NGS HIVDR assays.
Recognition of Reovirus RNAs by the Innate Immune System
Authors: Abad Andrew T. , Danthi Pranav
Published: June 2020

Mammalian orthoreovirus (reovirus) is a dsRNA virus, which has long been used as a model system to study host–virus interactions. One of the earliest interactions during virus infection is the detection of the viral genomic material, and the consequent induction of an interferon (IFN) based antiviral response. Similar to the replication of related dsRNA viruses, the genomic material of reovirus is thought to remain protected by viral structural proteins throughout infection. Thus, how innate immune sensor proteins gain access to the viral genomic material, is incompletely understood. This review summarizes currently known information about the innate immune recognition of the reovirus genomic material. Using this information, we propose hypotheses about host detection of reovirus.
Adeno-Associated Virus (AAV) Capsid Stability and Liposome Remodeling During Endo/Lysosomal pH Trafficking
Authors: Lins-Austin Bridget , Patel Saajan , Mietzsch Mario , Brooke Dewey , Bennett Antonette , Venkatakrishnan Balasubramanian , Van Vliet Kim , Smith Adam N. , Long Joanna R. , McKenna Robert , Potter Mark , Byrne Barry , Boye Sanford L. , Bothner Brian , Heilbronn Regine , Agbandje-McKenna Mavis
Published: June 2020

Adeno-associated viruses (AAVs) are small, non-pathogenic ssDNA viruses being used as therapeutic gene delivery vectors for the treatment of a variety of monogenic diseases. An obstacle to successful gene delivery is inefficient capsid trafficking through the endo/lysosomal pathway. This study aimed to characterize the AAV capsid stability and dynamics associated with this process for a select number of AAV serotypes, AAV1, AAV2, AAV5, and AAV8, at pHs representative of the early and late endosome, and the lysosome (6.0, 5.5, and 4.0, respectively). All AAV serotypes displayed thermal melt temperatures that varied with pH. The stability of AAV1, AAV2, and AAV8 increased in response to acidic conditions and then decreased at pH 4.0. In contrast, AAV5 demonstrated a consistent decrease in thermostability in response to acidification. Negative-stain EM visualization of liposomes in the presence of capsids at pH 5.5 or when heat shocked showed induced remodeling consistent with the externalization of the PLA2 domain of VP1u. These observations provide clues to the AAV capsid dynamics that facilitate successful infection. Finally, transduction assays revealed a pH and temperature dependence with low acidity and temperatures > 4 °C as detrimental factors.
mRNA Profile in Milk Extracellular Vesicles from Bovine Leukemia Virus-Infected Cattle
Authors: Ishikawa Hinata , Rahman Md. Matiur , Yamauchi Marika , Takashima Shigeo , Wakihara Yoshiko , Kamatari Yuji O. , Shimizu Kaori , Okada Ayaka , Inoshima Yasuo
Published: June 2020

Milk extracellular vesicles (EVs) form an excellent source of mRNAs, microRNAs (miRNAs), proteins, and lipids that represent the physiological and pathological status of the host. Recent studies have reported milk EVs as novel biomarkers for many infectious diseases in both humans and animals. For example, miRNAs in milk EVs from cattle were used for early detection of bacterial infection in the mammary gland. Based on these findings, we hypothesized that mRNAs in milk EVs are suitable for gaining a better understanding of the pathogenesis of bovine leukemia virus (BLV) infection and prognosis of the clinical stage in cattle. For that purpose, milk EVs were isolated from BLV-infected and uninfected cattle, and mRNAs were investigated using microarray analysis. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed mainly focusing on the differentially expressed genes (DEGs) in milk EVs from BLV-infected cattle. GO and KEGG analyses suggested the DEGs in milk EVs from BLV-infected cattle had involved in diverse molecular functions, biological processes, and distinct disease-related pathways. The present study suggested that BLV infection causes profound effects on host cellular activity, changing the mRNA expression profile in milk EVs obtained from BLV-infected cattle. Overall, our results suggested that the mRNA profile in milk EVs to be a key factor for monitoring the clinical stage of BLV infection. This is the first report of mRNA profiling of milk EVs obtained from BLV-infected cattle.
Effects of Oral Antihistamines on Tear Volume, Tear Stability, and Intraocular Pressure
Authors: Foutch Brian K. , Sandberg Kyle A. , Bennett Edward S. , Naeger Leonard L.
Published: June 2020

The goal of this study was to investigate the effects of two commonly used oral antihistamines—diphenhydramine and loratadine—on tear volume, tear breakup time, and intraocular pressure. Placebo, diphenhydramine, and loratadine were administered for one week to 33 subjects experimentally blind to the treatment given. All the subjects received all three treatments over a period of six weeks. The outcome measures were the change in phenol red thread test (PRT), the tear breakup time (TBUT), and the intraocular pressure (IOP) of both eyes evaluated by experimentally masked observers. Neither of the mean changes in TBUT or IOP depended on the treatment given, but there was a significant monocular decrease in tear volume from diphenhydramine use. While we used an adequate treatment washout period of seven days, our investigation was limited by the short treatment times and inclusion of only young healthy patients. Overall, however, these results suggest that systemic diphenhydramine use should be limited to increase the effectiveness of conventional therapies. Clinicians should have fewer reservations about recommending the use of loratadine concurrent with dry eye treatments.
Trends and variation in unsafe prescribing of methotrexate: a cohort study in English NHS primary care
Authors: MacKenna Brian , Curtis Helen J , Walker Alex J , Croker Richard , Bacon Seb , Goldacre Ben
Published: June 2020

Background

Prescribing high doses of methotrexate increases the potentially fatal risk of toxicity. To minimise risk, it is recommended that only 2.5 mg tablets are used.

Aim

To describe trends in GP prescribing of methotrexate over time; the harm associated with methotrexate errors at a national level; ascertain variation between practices and clinical commissioning groups (CCGs) in their implementation of the safety guidance; and map current variations at CCG and practice level.

Design and setting

A retrospective cohort study of English GP prescribing data (August 2010–April 2018), and data acquired via freedom of information (FOI) requests.

Method

The main outcome measures were: variation in ratio of non-adherent/adherent prescribing, geographically and over time, between practices and CCGs; and description of responses to FOI requests.

Results

Of 7349 practices in England, 1689 prescribed both 2.5 mg and 10 mg tablets to individual patients in 2017, breaching national guidance. In April 2018, 697 practices (≥90th percentile) prescribed >14.3% of all methotrexate as 10 mg tablets, likewise breaching national guidance. The 66 practices at ≥99th percentile gave >52.4% of all prescribed methotrexate in the form of 10 mg tablets. The prescribing of 10 mg tablets fell during the study period, with 10 mg tablets as a proportion of all prescribed methotrexate tablets falling from 9.1% to 3.4%. Twenty-one deaths caused by methotrexate poisoning were reported from 1993–2017 in England and Wales.

Conclusion

The prevalence of unsafe methotrexate prescribing has reduced but remains common, with substantial variation between practices and CCGs. The authors recommend investment in better strategies around implementation. As 21 deaths that occurred from 1993–2017 in England and Wales were attributed to methotrexate poisoning, the coroners’ reports for these deaths should be reviewed to identify recurring themes.
Transtornar hábitos educativos: o que ainda é possível em terras arrasadas?
Authors: Cazetta Valéria , Preve Ana Maria Hoepers , Lenzi Maria Helena
Published: June 2020

Transtornar hábitos educativos: o que ainda é possível em terras arrasadas?
A formação de professores no Brasil e sua mecânica de subjetivação
Authors: Corrêa Guilherme , Rigue Fernanda Monteiro , Feltrin Tascieli
Published: June 2020

A formação de professores no Brasil e sua mecânica de subjetivação
Cartografias e criação de mundos fictícios: leituras outras na educação geográfica
Authors: Fabrício Deyse Cristina Brito , Cazetta Valéria
Published: June 2020

Cartografias e criação de mundos fictícios: leituras outras na educação geográfica
How Doctors Care for Others: Caring, Being with and Making the Difference
Authors: Castro Neves Mariana Barstad , Grillo Rafaela Oliveira , Sollero-De-Campos Flavia
Published: June 2020

Although more frequent and intense on infancy, the attachment system can be triggered across the lifespan, from "the cradle to the grave." In adulthood, whenever the individual's internal working model does not have enough resources to sustain his/her insecurity, one seeks support from an attachment figure. Illness may trigger the attachment system, obliging the individual to pursue the proximity of an attachment figure. In our research on how the doctor's attachment style affects the doctor-patient relationship (Barstad-Castro Neves, 2018), we assessed the doctor's attachment style and correlated with a semi-structured interview script. One of the categories highlighted in our research was how physicians cared for their patients. The present article aims to explore, expand, and clarify the category mentioned. It is essential to discuss how the car ing and concerning doctor acts towards his/her patient, and how the caregiving system, from the lens of attachment theory, has a function in that matter. Our research may contribute to the discussion of strategies to improve the doctor-patient relationship, therefore refining patient adherence and compliance to treatment. Besides, it can also shed light on how to give support to medical professionals, starting from medical school.
Mechanism of Film Boiling Elimination and IQ Process Design for Hardening Steel in Low Concentration of Water Polymer Solutions
Authors: Kobasko Nikolai I.
Published: June 2020

The paper considers a mechanism of the elimination of the film boiling process during intensive quenching (IQ) of steel parts in water polymer solutions of low concentration. The use of the IQ process results in improvement of material mechanical properties and steel part performance characteristics. Evaluation of ways of eliminating of the film boiling process using a modern physics point of view allows significant improvement of the IQ equipment making it less costly and more efficient. All of this cardinally simplifies the implementation of the IQ technology in heat treat practice. The paper shows how creation of a thin insulating surface layer during quenching of steel parts in low concentration of inverse solubility polymers results in eliminating of film boiling processes that makes the quench process intensive. Historically in heat treating industry, an effective heat transfer coefficient was widely used for evaluating of the nucleate boiling process. And quenching during the nucleate boiling mode of heat transfer was considered as slow cooling.
LITERASI MEDIA DIGITAL BAGI GURU PAUD GUGUS KENANGA DI KECAMATAN DUKUHSETI KABUPATEN PATI
Authors: Saidillah Raodah , Ali Subhan
Published: June 2020

This outreach program is Digital Media Literacy Training for early childhood education (PAUD) Teachers of Kenanga Group in Dukuhseti district, Pati regency. This digital media literacy training activity aims to provide knowledge and insight into early childhood education (PAUD) Teachers to take advantage of digital-based media both in learning and administration. This outreach program was held for two days on Thursday-Friday, 29-30 August 2019 at TK Tunas Bangsa. The material presented includes; the urgency and function of digital media for learning and administration, typing using Microsoft Word, presenting with PowerPoint, scanning documents using a device, and using the WhatsApp application by computer or laptop. It is designed in the form of training using three methods. They are lecture method, demonstration method, and direct practice method. The results indicate that this program significantly increases in knowledge, understanding, expertise and, skills of the participants. It can be seen from the results of the pretest and posttest that have been implemented. Participants were also very satisfied with the dedication activities that had been carried out because the material presented was fit their needs and the methods used were also appropriate. From all the evaluation results in the form of pretest, posttest and feedback from the participants, it was concluded that this outreach program has achieved the goal they are the participants understand and can apply digital media for learning and administration.
PELESTARIAN DOLANAN ANAK DI DUSUN SIDOREJO DESA SIDOREJO KECAMATAN KRIAN KABUPATEN SIDOARJO
Authors: Khoirul Ngibad  , Ernawati  , Anis Putri Ambarwati  , Ayu Putri C.  , M. Ali Zainuddin  , Nanda Ady Cahyono
Published: June 2020

Sidorejo backwoods is backwoods located in the v Sidorejo illage, Krian District, Sidoarjo Regency. The condition of preservation of dolanan anak or traditional games in Sidorejo backwoods is currently very poor. Most children in Sidorejo backwoods are more familiar with modern games, such as: online games, playstation and others. Based on the results of a survey conducted by students of Kuliah Kerja Nyata (KKN) in Sidorejo backwoods, it can be seen that the community of Sidorejo backwoods less responsive to the activity of reviving dolanan anak.. Therefore, the aim of Community Service is to preserve local culture through dolanan anak which is one part of the core program carried out by students of KKN from Universitas Maarif Hasyim Latif in order to preserve the existing local culture. The community service activities that are conceptualized in Kuliah Kerja Nyata (KKN) scheme involved students of Universitas Maarif Hasyim Latif from various study programs guided by Field Supervisors. The implementation of community service begins with initial observations in the field of traditional games among school children from Dusun Sidorejo RW 04 and 05 and then determines the schedule of dolanan anak activities through traditional children's play followed by all children from Dusun Sidorejo RW 04 and 05. The results of this community service program have made the children more enthusiastic to revive the existing traditional games. The parents do not forbid their children to play traditional games so that it can support the success of programs run by students from Universitas Maarif Hasyim Latif in the village of Sidorejo.
MODEL PENGEMBANGAN RADIO DBS FM DALAM UPAYA MENCAPAI KEUNGGULAN KOMPETITIF DI FAKULTAS DAKWAH UNIVERSITAS IBRAHIMY
Authors: Syafii Imam
Published: June 2020

The output of the DBS FM Radio program should be based on a vision and mission that is generally required to fulfill the trilogy rules of the broadcast radio function, which is to inform, educate and entertain. The three do not stand alone because they are a unitary target. The vision and mission of DBS FM Radio broadcast cannot be separated from the vision and mission of the Da'wah Faculty of Ibrahimy University as a logical consequence in its position as campus radio, student practicum radio. The flow that must be understood by DBS FM Radio broadcasting organizers should be different from commercial radio broadcasting. The communication pattern and broadcast material must be able to meet the target audience of the audience, namely students, students and the community around the Salafiyah Syafiiyah Islamic Boarding School Sukorejo Situbondo. Efforts must be made to obtain a goal setting with the SMART formula that is expected to be able to create changes from existing conditions to better conditions with HR qualifications that have the ability to announce skills, operating skills and attitude skills, namely by assisting the development model as a replicable alternative effort to achieve competitive advantage.
UPAYA PEMBERDAYAAN MASYARAKAT MELALUI PENGHIMPUNAN DANA KOINISASI DI DESA NGRONGGOT KECAMATAN NGRONGGOT KABUPATEN NGANJUK
Authors: Moh. Hasyim Afandi  , Zainal Arifin  , Ramdhan Tri Wahyudi
Published: June 2020

Nahdlatul Ulama, the majority of whose members are mostly from the lower class, initiated to collect coins from members. All members are asked to participate. Therefore Board of Management of Nahdlatul Ulama Nganjuk regency launched the NU Caring Coin Movement program. It is the movement of NU members to collect coins from the homes of residents of Nahdliyin whose benefits are to solve various problems in aspects of life and realize the independence of jam'iyyah. The results of the mentoring activities obtained were first, the condition of Ngronggot village society before the mentoring although the spirit of diversity and social solidarity was very high but still individual. Second, The form of the assistance activities carried out included awareness of their potential so that they always think positively, and vocational training the following applications so that new interpreneurs emerge. Third, after the mentoring program is complete, community trust in self potential, both economic and religious, emerges together to support each other both in religious and social activities.
İşveren Markası Oluşumunu Etkileyen Sosyo-Demografik Unsurlar Turizm Sektörü Örneği
Authors: YAVAN TEMİZKAN Öznur , YORULMAZ Funda
Published: June 2020

İşveren markası, işveren tarafından sağlanan işlevsel, ekonomik, psikolojik
faydaların paketi olarak tanımlanmakta ve istihdamla özdeşleştirilebilir olduğu
ifade edilmektedir. İşveren markası oluşumunu etkileyebileceği düşünülen
sosyo-demografik unsurlardan cinsiyet, yaş, eğitim durumu, mesleki rol, aylık
kazanç ve marka çalışması eğitimine katılma durumuna göre bir farklılığın olup
olmadığı Antalya ilinde faaliyet gösteren beş yıldızlı otellerde incelenmiştir.
Anket yöntemiyle elde edilen verilerin puan dağılımları normal dağılmadığından
non-parametrik istatistiklerden Mann WhitneyU ve Kruskal WallisH testleri ile
değerlendirilmiştir. Analizler sonucunda işveren markası oluşumunda cinsiyet
açısından anlamlı bir farklılık olmadığı ancak yaş, eğitim durumu, mesleki rol,
aylık kazanç ve marka çalışması eğitimine katılma durumuna göre anlamlı
farklılıklar olduğu sonucuna ulaşılmıştır.
Diplomasinin Değişen Tanımları Ad Hoc Diplomasiden Twiplomacy ve Tekploması Çağına
Authors: ERCAN Arda
Published: June 2020

1990’lı yılların başında hayatımıza giren internet kavramı, klasik uluslararası ilişkiler algısının ve diplomasinin temel kabullerinin sorgulanmasına yol açmıştır. Devlet kadar eski kökene sahip olan, 15. Yüzyılda Ad hoc (geçici) nitelikte bir anlayışla kurumsallaşan, 1815 Viyana Kongresi ile kuralları belirlenen diplomasi, günümüzde tüm bu kuralları yıkan dijital diplomasi kavramına yenik düşmektedir. Birleşmiş Milletler ’in üye ülkelerinin %97 oranında dijital diplomasi kullandığı göze alındığında, bu mecranın dış politikada belirleyici unsur haline geldiğini kabul etmek ve dış politika karar alma süreçlerini bu doğrultuda yeniden yapılandırmak gerekmektedir.Bu çalışmada Danimarka’nın Silikon Vadisinde dijital büyükelçi ataması gerçeğinden hareketle, sanal sınırların olduğu sanal dünyada diplomasi araçlarının nasıl kullanıldığı ve dış politika algısının bu yeni dönemde nasıl şekillenmesi gerektiği tartışılacaktır.
The complete framework of Universal Numbers
Authors: Shah Balram A
Published: June 2020

This paper contains the complete framework of universal numbers along with the universal forms with a complete framework. There are many limitations in real numbers over universal numbers that are discussed in this article. But equations related to the complete framework of advanced number is rarely used in existing mathematics. So, very little research is conducted and research is been postponed for the future which can be conducted by anyone.
WPŁYW WARUNKU BRZEGOWEGO DIRICHLETA NA SZYBKOŚĆ I STABILNOŚĆ SYMULACJI PRĄDÓW WIROWYCH ELEKTRYCZNYM POTENCJAŁEM SKALARNYM
Authors: Płonecki Przemysław , Starzyński Jacek , Wincenciak Stanisław
Published: June 2020

Polem zastosowań prezentowanych wyników są problemy bioelektromagnetyzmu. Matematyczny opis prądów wirowych, przy wolnozmiennych wymuszeniach elektromagnetycznych pochodzących od płynącego w cewce prądu elektrycznego, został sformułowany w oparciu o skalarny potencjał elektryczny. W artykule przedstawiono oddziaływanie zadawania zerowego warunku brzegowego Dirichleta na jakość i szybkość otrzymywania wyników. Szereg testów numerycznych wykazał, iż nie zawsze jest on wskazany.
APLIKACJA MIKROBLOGOWA-HANDSHAKE
Authors: Kowalczyk Paweł , Słodyczka Tomasz , Smyk Ewelina , Sadura Przemysław
Published: June 2020

Artykuł zawiera prezentację możliwości aplikacji mikroblogowej zbudowanej przy pomocy frameworka Pylons w architekturze klient-serwer. Program jest skierowany na urządzenia mobilne wszystkich platform wspierających najnowszą specyfikację HTML5 oraz CSS3. Serwis wzorowany jest na portalu Twitter.
REDUKCJA WYMIAROWOŚCI DANYCH A SELEKCJA CECH W ZASTOSOWANIU DO PROGNOZOWANIA MAKSYMALNEGO DOBOWEGO OBCIĄŻENIA ELEKTROENERGETYCZNEGO
Authors: Siwek Krzysztof
Published: June 2020

Prognozowanie obciążeń w systemie elektroenergetycznym jest ważnym problemem praktycznym zarówno z technicznego jak i ekonomicznego punktu widzenia. W małych systemach problem ten jest stosunkowo trudny do rozwiązania ze względu na dużą zmienność przebiegu obciążenia. Do jego rozwiązania niezbędne jest zastosowanie dobrego predykatora i wyselekcjonowanie cech procesu wpływających na prognozę. Artykuł przedstawia dwie metody selekcji cech – algorytm genetyczny oraz algorytmy redukcji wymiarowości. Jako predykator użyta była maszyna wektorów podtrzymujących działająca w trybie regresji (SVR). Zaprezentowano i omówiono uzyskane wyniki na rzeczywistych danych pomiarowych.
AN INTEGRATED RISK INFORMED DECISION MAKING IN THE NUCLEAR INDUSTRY
Authors: Borysiewicz Mieczysław Józef , Kowal Karol , Prusiński Piotr , Dąbrowski Marcin
Published: June 2020

The regulatory body, established to ensure safety of nuclear facilities, is expected to make right decisions and provide appropriate regulations for the nuclear industry. The traditional manner of its activity has been based on a deterministic approach to safety analyses. However, increased maturity of Probabilistic Safety Assessment (PSA) makes it complementary to deterministic studies. The new IAEA concept, described in this article, is to apply an integrated approach by combining both deterministic and probabilistic insights with other requirements affecting the decision making process.
NOWA METODA TUNELOWEGO WYZNACZANIA MACIERZY WRAŻLIWOŚCI DLA POTRZEB PROCESU REKONSTRUKCJI OBRAZÓW DLA TRÓJWYMIAROWEJ TOMOGRAFII POJEMNOŚCIOWEJ
Authors: Wajman Radosław , Banasiak Robert
Published: June 2020

Macierz wrażliwości jest głównym czynnikiem wpływającym na finalną jakość wyników procesu rekonstrukcji obrazów dla trójwymiarowej elektrycznej tomografii pojemnościowej 3D ECT. Dotychczasowe metody ich wyznaczania dają w większości przypadków dobre wyniki rekonstrukcji i umożliwiają dodatkowo wykonanie procesu iteracyjnej aktualizacji map wrażliwości, dostosowując ich naturę do zmieniającego się wraz z procesem rekonstrukcji symulowanego rozkładu pola elektrycznego. W ramach niniejszego artykułu autorzy przedstawią własną istotną modyfikację procesu wyznaczania map wrażliwości poprzez uwzględnienie w tym procesie szczegółowego rozkładu pola we wnętrzu czujnika. Opracowany nowy tunelowy algorytm wyznaczania macierzy wrażliwości konstruuje mapy wrażliwości w oparciu o śledzenie powierzchni budowanych wzdłuż linii sił pola elektrycznego. W artykule zostaną przedstawione wyniki procesu rekonstrukcji obrazów, które wykażą większą skuteczność nowej metody.
IDENTYFIKACJA PRZEPŁYWU DWUFAZOWEGO GAZ-CIECZ OPARTA NA OCENIE ROZMYTEJ OBRAZÓW TOMOGRAFICZNYCH 3D
Authors: Jaworski Tomasz , Fiderek Paweł , Wajman Radosław , Banasiak Robert
Published: June 2020

Prezentowany artykuł przedstawia wyniki prac nad systemem automatycznego rozpoznawania przepływów dwufazowych gaz-ciecz w rurociągach poziomych i pionowych. Opiera się on na logice rozmytej przy ocenie obrazów przestrzennych z tomografii 3D a następnie na przyporządkowaniu uzyskanych ocen do jednej z klas przepływu.
OCENA METROLOGICZNA SYSTEMU POMIAROWEGO DLA POTRZEB WYZNACZANIA UDZIAŁU FAZ W PRZEPŁYWIE MIESZANIN GAZ-CIECZ METODĄ TOMOGRAFII POJEMNOŚCIOWEJ 3D
Authors: Wajman Radosław , Fidos Henryk , Fiderek Paweł , Jaworski Tomasz , Nowakowski Jacek , Sankowski Dominik , Banasiak Robert
Published: June 2020

Przemysłowe systemy diagnostyki i monitorowania potrzebują nowych narzędzi oferujących możliwości nieinwazyjnej obserwacji i analizy procesów przepływów dwufazowych mieszanin gaz-ciecz. Opracowany system pomiarowy dedykowany jest dla potrzeb nieinwazyjnego wyznaczania procentowego udziału faz oraz identyfikacji struktur w przepływach dwufazowych w rurociągach pionowych i poziomych. Artykuł prezentuje wybrane rezultaty prac badawczych, w wyniku, których dokonano oceny własności metrologicznych prototypowego systemu trójwymiarowej tomografii pojemnościowej. Prace badawcze obejmowały między innymi: zagadnienie optymalizacji struktury czujnika ECT, a także metrologiczną ocenę dokładności rekonstrukcji obrazu oraz wyznaczania procentowego udziału faz w porównaniu z innymi metodami. W wyniku przeprowadzonej analizy wykazano dużą przydatność systemu 3D ECT do nieinwazyjnego, szybkiego diagnozowania dynamicznych procesów przepływowych.
ANALIZA STEROWANIA UŁAMKOWEGO PIλDµ MOCĄ REAKTORA JĄDROWEGO
Authors: Puchalski Bartosz , Duzinkiewicz Kazimierz , Rutkowski Tomasz
Published: June 2020

W artykule przedstawiono syntezę regulatora PIλDμ niecałkowitego rzędu dla potrzeb sterowania mocą reaktora jądrowego lekko wodnego określanego, jako typu PWR (Pressurized Water Reactor). W tym celu wykorzystano nieliniowy model matematyczny reaktora PWR o parametrach skupionych obejmujący procesy generacji i wymiany ciepła oraz termicznych efektów reaktywnościowych. Nastawy regulatora PIλDμ niecałkowitego rzędu dobrano w sposób optymalny, minimalizując klasyczne całkowe wskaźniki jakości określane na bazie odpowiedzi skokowej. Na przykładzie najpierw układu oscylacyjnego drugiego rzędu, a potem na przykładzie liniowego modelu reaktora PWR otrzymanego z linearyzacji modelu nieliniowego w określonym punkcie pracy wykazano, że proponowany ułamkowy regulator PIλDμ może stać się alternatywą dla powszechnie stosowanego klasycznego regulatora PID.
OCHRONA ZABYTKOWYCH RUIN - PROBLEMY BADAWCZE I PROJEKTOWE NA PRZYKŁADZIE ZAMKU W SOCHACZEWIE
Authors: Brykowska Maria
Published: June 2020

Badania historyczne ruin zamków, a następnie prace konserwatorskie - są procesem złożonym i wieloetapowym. W związku z zagrożeniem katastrofą ruin zamku w Sochaczewie Zespół Badań nad Polskim Średniowieczem, wykonał kompleksowe badania (historyczne, architektoniczne, archeologiczne i techniczne) oraz projekty: konserwacji ruin i zagospodarowania otoczenia. Badania prowadzili w 1966 r.: historyk sztuki Izabela Galicka, archeolog Jerzy Piniński i architekt Maria Brykowska (kierownik i autor projektu); konsultował prace prof. Jan Zachwatowicz.Ustalono: poziom użytkowania i spalenia grodu (XIII w. - 7,0 m pod nasypem), relikty zamku gotyckiego (poł. XIV w.) i zamek budowany przez starostę Stanisława Radziejowskiego (przed 1630). Następnie wykonano projekt architektoniczny zabezpieczenia ruin (nie zrealizowany).W 1975-77 r. badania w północnej części zamku wykonał Jerzy Gula, a w latach 2006-2007 ekipa pod kierunkiem Leszka Kajzera – w części południowej i wschodniej; odkryto budynek bramny z czasów starosty Krzysztofa Szydłowieckiego i według źródeł z XVI w. – kilka drewnianych domów. Badania z lat 2011-2013– stanowiły podstawę dotacji UE do realizacji nowego projektu dla celów turystycznych i zabezpieczenia ruin, pod nadzorem konserwatorskim architekta Cezarego Głuszka.W 1966 r. architekt Jarosław Skrzypczyk wykonał projekt otocznie zamku (zrealizowany), a w 2013 r. uporządkowano teren według poprzedniej koncepcji.Wieloletnie doświadczenie w organizacji badań i naukowej interpretacji odkryć, dla ochrony wartości zabytkowej ruiny wraz z terenem – stanowiły podstawę propozycji zmian do „Karty historycznych ruin”.
KOROZJA BIOLOGICZNA I ROŚLINNOŚĆ A TRWAŁA RUINA
Authors: Trochonowicz Maciej , Klimek Beata , Lisiecki Daniel
Published: June 2020

W artykule przedstawiono mechanizmy biodegradacji struktur w obiektach historycznych przeznaczonych do ekspozycji w postaci trwalej ruiny oraz zasady postępowania przy usuwaniu niepożądanej roślinności w tychże obiektach. Szczególną uwagę poświecono zagadnieniom związanym z różnorodnością uszkodzeń spowodowanych przez organizmy żywe. Zaprezentowano zasady postępowania przy usuwaniu zarówno glonów porostów i grzybów, jak również procedury działania przy zwalczaniu niepożądanej roślinności wyższej.
KOMPLEKS MŁYNA SOLNEGO I MAGAZYNÓW BYŁEJ KOPALNI SOLI W WAPNIE. UWARUNKOWANIA I PRZESŁANKI DO OCHRONY XX-WIECZNYCH BUDOWLI POPRZEMYSŁOWYCH JAKO TRWAŁEJ RUINY
Authors: Urbaniak Miron
Published: June 2020

W dawnej kopalni soli zniszczonej przez wodę w 1977 r. w małej wiosce Wapno w Wielkopolsce widać z daleka zespół młyna solnego wraz z magazynami solnymi. Zaprojektowane przez prof. Bronisława Bukowskiego (1893-1965), wzniesione w latach 1929-1930 przez C. Lubińskiego i K. Jaskulskiego z Warszawy budynki mają żelbetowy system ramowy i słupową konstrukcję nośną. Układ charakteryzuje ogromna skala, nieproporcjonalna do rzeczywistych potrzeb wioski, co utrudnia wszelkie działania rewitalizacjne i adaptacjne do nowych funkcji. Jednak wartość budynków dla historii i panoramy miasta Wapno, będącym niegdyś stolicą największej w Polsce kopalni soli, dla krajobrazu kulturowego Wielkopolski, a wreszcie dla historii polskiego wydobycia soli i polskiej szkoły betonu i konstrukcji z betonu zbrojonego jest trudna do oszacowania. Dlatego bez względu na pogarszającą się kondycję kompleks powinien być chroniony i zachowany w krajobrazie kulturowym Wielkopolski jako cenny zabytek techniki. Tym samym jedynym sposobem na jego ochronę jest zachowanie go w postaci trwałej ruiny.