bluuebunny/crossref_metadata_2025 huggingface dataset:
Cell-free DNA promotes malignant transformation in non-tumor cells
Authors: Souza Aline Gomes de , Bastos Victor Alexandre F. , Fujimura Patricia Tieme , Ferreira Izabella Cristina C. , Leal Letícia Ferro , da Silva Luciane Sussuchi , Laus Ana Carolina , Reis Rui Manuel , Martins Mario Machado , Santos Paula Souza , Corrêa Natássia C. Resende , Marangoni Karina , Thomé Carolina Hassibe , Colli Leandro Machado , Goulart Luiz Ricardo , Goulart Vivian Alonso
Published: December 2020

Cell-free DNA is present in different biological fluids and when released by tumor cells may contribute to pro-tumor events such as malignant transformation of cells adjacent to the tumor and metastasis. Thus, this study analyzed the effect of tumor cell-free DNA, isolated from the blood of prostate cancer patients, on non-tumor prostate cell lines (RWPE-1 and PNT-2). To achieve this, we performed cell-free DNA quantification and characterization assays, evaluation of gene and miRNA expression profiling focused on cancer progression and EMT, and metabolomics by mass spectrometry and cellular migration. The results showed that tumor-free cell DNA was able to alter the gene expression of MMP9 and CD44, alter the expression profile of nine miRNAs, and increased the tryptophan consumption and cell migration rates in non-tumor cells. Therefore, tumor cell-free DNA was capable of altering the receptor cell phenotype, triggering events related to malignant transformation in these cells, and can thus be considered a potential target for cancer diagnosis and therapy.
A comprehensive analysis on nanostructured materials in a thermoelectric micro-system based on geometric shape, segmentation structure and load resistance
Authors: Olivares-Robles Miguel Angel , Badillo-Ruiz Carlos Alberto , Ruiz-Ortega Pablo Eduardo
Published: December 2020

In this study, we report the novel energy behavior of high-performance nanostructured materials in a segmented thermoelectric micro-generator (TEG). Several physical elements of the materials must be considered to determine their behavior in the thermoelectric energy conversion: temperature dependence of material properties, geometric structure, segmentation, and the symmetry of each or both p-type and n-type nanostructure semiconductor thermoelements. Recently, many efforts have reported effects independent on the thermoelectric performance of semiconductor materials. In this work, exhaustive research on the performance of high-performance nanostructured materials in a segmented thermoelectric micro-generator (TEG) was carried out. Our results show the efficiency and output power of the TEG using the temperature-dependent model, i.e., a variable internal resistance for a load resistance of the system. Our approach allows us to analyze symmetrical and asymmetric geometries, showing maximum and minimum peaks values in the performance of the TEG for specific $$\gamma $$
γ
values. The performance of the TEG is improved by about $$6\%$$

6
%

and $$7\%$$

7
%

, for efficiency, and output power, respectively, considering a trapezoidal geometric shape in the 2p-3n segmented system, compared with the conventional rectangular shape.
RNA sequencing reveals changes in the microRNAome of transdifferentiating hepatic stellate cells that are conserved between human and rat
Authors: Sabater Laura , Locatelli Luigi , Oakley Fiona , Hardy Timothy , French Jeremy , Robinson Stuart M. , Sen Gourab , Mann D. A. , Mann Jelena
Published: December 2020

MicroRNAs are small (~ 22nt long) noncoding RNAs (ncRNAs) that regulate gene expression at the post-transcriptional level. Over 2000 microRNAs have been described in humans and many are implicated in human pathologies including tissue fibrosis. Hepatic stellate cells (HSC) are the major cellular contributors to excess extracellular matrix deposition in the diseased liver and as such are important in the progression of liver fibrosis. We employed next generation sequencing to map alterations in the expression of microRNAs occurring across a detailed time course of culture-induced transdifferentiation of primary human HSC, this a key event in fibrogenesis. Furthermore, we compared profiling of human HSC microRNAs with that of rat HSC so as to identify those molecules that are conserved with respect to modulation of expression. Our analysis reveals that a total of 229 human microRNAs display altered expression as a consequence of HSC transdifferentiation and of these 104 were modulated early during the initiation phase. Typically modulated microRNAs were targeting kinases, transcription factors, chromatin factors, cell cycle regulators and growth factors. 162 microRNAs changed in expression during transdifferentiation of rat HSC, however only 17 underwent changes that were conserved in human HSC. Our study therefore identifies widespread changes in the expression of HSC microRNAs in fibrogenesis, but suggests a need for caution when translating data obtained from rodent HSC to events occurring in human cells.
Optimization of the spherical integrity for sustained-release alginate microcarriers-encapsulated doxorubicin by the Taguchi method
Authors: Pan C. T. , Chien S. T. , Chiang T. C. , Yen C. K. , Wang S. Y. , Wen Z. H. , Yu C. Y. , Shiue Y. L.
Published: December 2020

This study aimed to develop biodegradable calcium alginate microcarriers with uniform particle size and spherical integrity for sustained-release targeting transarterial chemoembolization. To determine related parameters including the ratio of cross-linking volume (sodium alginate: CaCl2), concentrations of sodium alginate and CaCl2 solutions, collection distance, flow rate, stirring speed, syringe needle diameter and hardening time to fabricate the microcarriers, the Taguchi method was applied. Using different conditions, a total of 18 groups were prepared. The average size of microspheres from different groups was estimated as ~ 2 mm (range 1.1 to 1.6 mm). Signal-to-noise ratio analysis showed the optimal spherical integrity (F1) achieved when the above parameters were designed as 0.1, 2.5 wt%, 6 wt%, 8 cm, 30 mL/h, 150 rpm, 0.25 mm and 2 h, respectively. The best (F1), middle (F2) and worst (F3) groups were used for further experiments. Fourier-transform infrared spectroscopy spectrum showed that F1, F2 and F3 conformations were distinct from original sodium alginate. Drug-loaded calcium alginate microcarriers demonstrated rougher surfaces compared to microspheres without drug under transmission electron microscopy. Compared to pH 7.4, swelling rates in PBS were decreased at pH 6.5. Encapsulation and loaded efficiencies of the Dox-loaded microcarriers were estimated as ~ 40.617% and ~ 3.517%. In vitro experiments indicated that the F1 Dox-loaded microcarriers provide a well sustained-release efficacy for about two weeks at 37 °C in PBS. Treatments of calcium alginate microcarriers without the Dox in two distinct hepatocellular carcinoma-derived cell lines, Huh-7 and Hep-3B, indicated that these microcarriers were non-toxic. The Dox-loaded microcarriers displayed sustained-release capacity and reduced cell viabilities to ~ 30% in both cell lines on Day 12.
Phosphatidic acid increases Notch signalling by affecting Sanpodo trafficking during Drosophila sensory organ development
Authors: Medina-Yáñez Ignacio , Olivares Gonzalo H. , Vega-Macaya Franco , Mlodzik Marek , Olguín Patricio
Published: December 2020

Organ cell diversity depends on binary cell-fate decisions mediated by the Notch signalling pathway during development and tissue homeostasis. A clear example is the series of binary cell-fate decisions that take place during asymmetric cell divisions that give rise to the sensory organs of Drosophila melanogaster. The regulated trafficking of Sanpodo, a transmembrane protein that potentiates receptor activity, plays a pivotal role in this process. Membrane lipids can regulate many signalling pathways by affecting receptor and ligand trafficking. It remains unknown, however, whether phosphatidic acid regulates Notch-mediated binary cell-fate decisions during asymmetric cell divisions, and what are the cellular mechanisms involved. Here we show that increased phosphatidic acid derived from Phospholipase D leads to defects in binary cell-fate decisions that are compatible with ectopic Notch activation in precursor cells, where it is normally inactive. Null mutants of numb or the α-subunit of Adaptor Protein complex-2 enhance dominantly this phenotype while removing a copy of Notch or sanpodo suppresses it. In vivo analyses show that Sanpodo localization decreases at acidic compartments, associated with increased internalization of Notch. We propose that Phospholipase D-derived phosphatidic acid promotes ectopic Notch signalling by increasing receptor endocytosis and inhibiting Sanpodo trafficking towards acidic endosomes.
Efficacy and feasibility of proton beam radiotherapy using the simultaneous integrated boost technique for locally advanced pancreatic cancer
Authors: Kim Tae Hyun , Lee Woo Jin , Woo Sang Myung , Oh Eun Sang , Youn Sang Hee , Jang Hye Young , Han Sung-Sik , Park Sang-Jae , Suh Yang-Gun , Moon Sung Ho , Kim Sang Soo , Kim Dae Yong
Published: December 2020

To evaluate the clinical efficacy and feasibility of proton beam radiotherapy (PBT) using the simultaneous integrated boost (SIB) technique in locally advanced pancreatic cancer (LAPC), 81 LAPC patients receiving PBT using SIB technique were analyzed. The prescribed doses to planning target volume (PTV)1 and PTV2 were 45 or 50 GyE and 30 GyE in 10 fractions, respectively. Of 81 patients, 18 patients received PBT without upfront and maintenance chemotherapy (group I), 44 received PBT followed by maintenance chemotherapy (group II), and 19 received PBT after upfront chemotherapy followed by maintenance chemotherapy (n = 16) (group III). The median follow-up time was 19.6 months (range 2.3–57.6 months), and the median overall survival (OS) times of all patients and of those in groups I, II, and III were 19.3 months (95% confidence interval [CI] 16.8–21.7 months), 15.3 months (95% CI 12.9–17.7 months), 18.3 months (95% CI 15.9–20.7 months), and 26.1 months (95% CI 17.8–34.3 months), respectively (p = 0.043). Acute and late grade ≥ 3 toxicities related to PBT were not observed. PBT with the SIB technique showed promising OS for LAPC patients with a safe toxicity profile, and intensive combinations of PBT and chemotherapy could improve OS in these patients.
Heat induces end to end repetitive association in P. furiosus l-asparaginase which enables its thermophilic property
Authors: Sharma Pankaj , Tomar Rachana , Yadav Shivpratap Singh , Badmalia Maulik D. , Nath Samir Kumar , Ashish  , Kundu Bishwajit
Published: December 2020

It remains undeciphered how thermophilic enzymes display enhanced stability at elevated temperatures. Taking l-asparaginase from P. furiosus (PfA) as an example, we combined scattering shapes deduced from small-angle X-ray scattering (SAXS) data at increased temperatures with symmetry mates from crystallographic structures to find that heating caused end-to-end association. The small contact point of self-binding appeared to be enabled by a terminal short β-strand in N-terminal domain, Leu179-Val-Val-Asn182 (LVVN). Interestingly, deletion of this strand led to a defunct enzyme, whereas suplementation of the peptide LVVN to the defunct enzyme restored structural frameworkwith mesophile-type functionality. Crystal structure of the peptide-bound defunct enzyme showed that one peptide ispresent in the same coordinates as in original enzyme, explaining gain-of lost function. A second peptide was seen bound to the protein at a different location suggesting its possible role in substrate-free molecular-association. Overall, we show that the heating induced self-assembly of native shapes of PfA led to an apparent super-stable assembly.
Ultraviolet A irradiation induces ultraweak photon emission with characteristic spectral patterns from biomolecules present in human skin
Authors: Tsuchida Katsuhiko , Kobayashi Masaki
Published: December 2020

Oxidative stress is associated with photoaging of the skin as well as with skin cancer, and is therefore, critical to monitor. Ultraweak photon emission (UPE) is extremely weak light generated during the oxidative process in the living body and has been used as a non-invasive and label-free marker for the evaluation of oxidative stress. However, the mechanism of UPE generation is not clear. Therefore, we aimed to elucidate the molecular mechanism underlying UPE generation by analyzing the spectra of UPE generated from biomolecules in the skin during ultraviolet A (UVA) exposure. The spectra of UVA-induced UPE generated from linoleic acid, linolenic acid, elastin, phospholipids, and 5,6-dihydroxyindole-2-carboxylic acid were measured, and the spectrum of human skin tissue was also obtained. The spectral patterns varied for the different biomolecules and the peaks were distinct from those of the skin tissue. These results suggested that the UPE generated from skin tissue is a collection of light emitted by biomolecules. Moreover, we proposed that UPE is generated through a photosensitization reaction and energy transfer. The identified characteristic spectral patterns of UPE can be useful to elucidate UVA-induced oxidative stress in the skin, with implications for prevention and treatment of photoaging and skin diseases.
Author Correction: Atorvastatin but Not Pravastatin Impairs Mitochondrial Function in Human Pancreatic Islets and Rat β-Cells. Direct Effect of Oxidative Stress
Authors: Urbano Francesca , Bugliani Marco , Filippello Agnese , Scamporrino Alessandra , Di Mauro Stefania , Di Pino Antonino , Scicali Roberto , Noto Davide , Rabuazzo Agata Maria , Averna Maurizio , Marchetti Piero , Purrello Francesco , Piro Salvatore
Published: December 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Microenvironmental determinants of organized iPSC-cardiomyocyte tissues on synthetic fibrous matrices
Authors: DePalma Samuel J. , Davidson Christopher D. , Stis Austin E. , Helms Adam S. , Baker Brendon M.
Published: December 2020

This work provides microenvironmental design parameters to optimize iPSC-cardiomyocyte tissues formed on tunable synthetic matrices that mimic myocardial ECM.
STAT3/IL-6 dependent induction of inflammatory response in osteoblast and osteoclast formation in nanoscale wear particle-induced aseptic prosthesis loosening
Authors: Deng Zhantao , Zhang Ruiying , Li Mengyuan , Wang Shuai , Fu Guangtao , Jin Jiewen , Wang Zhenheng , Ma Yuanchen , Zheng Qiujian
Published: December 2020

Our study demonstrated wear particles, which are generated by the abrasion of implanted prostheses, could induced STAT3 activation in osteoblasts. And further, inflammatory responses and RANKL expression would activate osteoclasts and cause osteolysis.
Spatially controlled glycocalyx engineering for growth factor patterning in embryoid bodies
Authors: Naticchia Matthew R. , Laubach Logan K. , Honigfort Daniel J. , Purcell Sean C. , Godula Kamil
Published: December 2020

Growth factor (GF) patterning in stem cell spheroids, such as embryoid bodies (EBs), has been sought to guide their differentiation and organization into functional 3D tissue models and organoids.
Stem cell recruitment based on scaffold features for bone tissue engineering
Authors: Xia Bin , Deng Yaxin , Lv Yonggang , Chen Guobao
Published: December 2020

Proper physical and chemical modification of a bone scaffold can effectively recruit endogenous stem cells to participate in the new bone formation.
High efficiency loading of micellar nanoparticles with a light switch for enzyme-induced rapid release of cargo
Authors: Choi Wonmin , Battistella Claudia , Gianneschi Nathan C.
Published: December 2020

High efficiency encapsulation is coupled with drug release via a light switch followed by particle disassembly via enzymatic action.
Imidazolium-based catenane host for bromide recognition in aqueous media
Authors: Serpell Christopher J. , Park Ah Young , Robinson Carol V. , Beer Paul D.
Published: December 2020

A tetracationic imidazolium-based catenane is reported which is selective for bromide over other halides in aqueous media.
Bismuth-induced synthesis of Au–X (X = Pt, Pd) nanoalloys for electrocatalytic reactions
Authors: Wang Nan , Zhao Wei , Zhang Miaolei , Cao Pengfei , Sun Shengjun , Ma Houyi , Lin Meng
Published: December 2020

The synthesis of Au–X (X = Pt, Pd) nanoalloys based on Bi as an intermediate using the galvanic replacement reaction method for electrocatalytic reaction.
d10 or d0? Theoretical and experimental comparison between rutile GeO2 and TiO2 for photocatalytic water splitting
Authors: Wang Rong , Li Qiaoqi , Li Weihua , Jiang Pengfei , Cong Rihong , Yang Tao
Published: December 2020

A comprehensive comparison between rutile-TiO2 and GeO2 proves that the d10 metal in octahedral coordination leads to a high charge mobility.
High performance sodium-sulfur batteries at low temperature enabled by superior molten Na wettability
Authors: Li Minyuan M. , Lu Xiaochuan , Zhan Xiaowen , Engelhard Mark H. , Bonnett Jeffrey F. , Polikarpov Evgueni , Jung Keeyoung , Reed David M. , Sprenkle Vincent L. , Li Guosheng
Published: December 2020

Raising the surface treatment temperature, ceramic solid-state electrolyte β′′-Al2O3 decorated with now highly metallic lead microspheres improves surface wetting of molten sodium and thus the performance of sodium-sulfur batteries.
Molecular tuning of the crystallization-induced emission enhancement of diphenyl-dibenzofulvene luminogens
Authors: Abdollahi Maryam F. , You Jian , Wang Tao , Zhao Yuming
Published: December 2020

The CIEE performances of diphenyl-dibenzofulvene luminogens are controlled by the twist angle of the CC double bond.
Remarkable untangled dynamics behavior of multicyclic branched polystyrenes
Authors: Xue Xiaoqiang , Chen Yangjing , Li Yongfang , Liang Kang , Huang Wenyan , Yang Hongjun , Jiang Li , Jiang Qimin , Chen Fangli , Jiang Tao , Lin Binzhe , Jiang Bibiao , Pu Hongting
Published: December 2020

The largest mesh sizeξof a multicyclic branched polymer network results in special microrheological behavior and unique viscosity modification applications in solution.
Modulation of destructive quantum interference by bridge groups in truxene-based single-molecule junctions
Authors: Wang Lin , Zhao Zhihao , Shinde Digambar B. , Lai Zhiping , Wang Dong
Published: December 2020

Nitrogen and carbonyl bridge substituents embedded in truxene derivatives enhance the single-molecule conductance prominently by alleviating the destructive quantum interference effect and pushing away the anti-resonance dip from the Fermi energy.
Determining the concentration and enantiomeric composition of histidine using one fluorescent probe
Authors: Mao Yifan , Abed Mehdi A. , Lee Nathan B. , Wu Xuedan , Du Gengyu , Pu Lin
Published: December 2020

A chemoselective as well as enantioselective fluorescent probe has been developed to determine both the concentration and enantiomeric composition of histidine.
Suzuki–Miyaura reaction of C–F bonds in fluorographene
Authors: Huang Feng , Li Yulong , Liu Xin , Lai Wenchuan , Fan Kun , Liu Xiangyang , Wang Xu
Published: December 2020

The regioselectivity of FG with a 2D structure achieves Suzuki reaction using C–F bonds.
Disintegration of excitons in π-conjugated molecules
Authors: Xie Jun , Sheng Weidong
Published: December 2020

Utilizing the exact diagonalization (ED) method, we find that excitons cannot form in π-conjugated molecules such as anthracene, phenanthrene, and pyrene when the electron–electron interaction is governed by the Rytova–Keldysh (RK) potential.
The transition from salt-in-water to water-in-salt nanostructures in water solutions of organic ionic liquids relevant for biological applications
Authors: Kumari P. , Pillai V. V. S. , Gobbo D. , Ballone P. , Benedetto A.
Published: December 2020

Computer simulations show how nano-structural motifs in organic salts/water solutions change with salt content increasing from dilute to highly concentrated.
Photoacoustic studies of energy transfer from ozone photoproducts to bath gases following Chappuis band photoexcitation
Authors: Cotterell Michael I. , Szpek Kate , Tiddeman David A. , Haywood Jim M. , Langridge Justin M.
Published: December 2020

We quantify the pressure dependent energy transfer timescales from Chappuis band photoproducts to bath gas mixtures of N2 and O2.
The dependence of the boson peak on the thickness of Cu50Zr50 film metallic glasses
Authors: Li Dongdong , Chen Heng , Qu Bingyan , Zhang Fabao , Zhou Rulong , Zhang Bo
Published: December 2020

In this study, intensive calculations were performed to investigate the behavior of the low-temperature excess heat capacity of Cu50Zr50 ultrathin film metallic glasses.
Small energy gap revealed in CrBr3 by scanning tunneling spectroscopy
Authors: Baral Dinesh , Fu Zhuangen , Zadorozhnyi Andrei S. , Dulal Rabindra , Wang Aaron , Shrestha Narendra , Erugu Uppalaiah , Tang Jinke , Dahnovsky Yuri , Tian Jifa , Chien TeYu
Published: December 2020

Using scanning tunneling spectroscopy (dI/dV) measurements, small energy gap was revealed in CrBr3 flakes.
Ab initiomolecular dynamics study of sodium NMR chemical shifts in the methylamine solution of [Na+[2.2.2]cryptand Na−]
Authors: Abella Laura , Philips Adam , Autschbach Jochen
Published: December 2020

NMR shielding constants for Na−and Na+are computed and analyzed based onab initiomolecular dynamics of [Na+[2.2.2]cryptand Na−] in methylamine. The analysis shows why solvated sodite ions exhibit free ion-like behavior in NMR experiments.
Characterizing photocatalysts for water splitting: from atoms to bulk and from slow to ultrafast processes
Authors: Kranz Christine , Wächtler Maria
Published: December 2020

This review provides a comprehensive overview on characterisation techniques for light-driven redox-catalysts highlighting spectroscopic, microscopic, electrochemical and spectroelectrochemical approaches.
Catalytic enrichment of plasma with hydroxyl radicals in the aqueous phase at room temperature
Authors: Audemar Maïté , Vallcorba Oriol , Peral Inma , Thomann Jean-Sébastien , Przekora Agata , Pawlat Joanna , Canal Cristina , Ginalska Grazyna , Kwiatkowski Michał , Duday David , Hermans Sophie
Published: December 2020

Iron oxide on mesoporous silica gave a synergy with plasma jet for HO˙ radical production at neutral pH.
Aerobic primary and secondary amine oxidation cascade by a copper amine oxidase inspired catalyst
Authors: Thorve Pradip Ramdas , Maji Biplab
Published: December 2020

A CAO inspired catalyst catalyzed the cascade aerobic oxidation of primary and secondary amines for the synthesis of quinazolin-4(3H)-one core in high yields. Like the natural CAOs, a copper ion improves the o-quinone cofactor's catalytic activity.
Surface acoustic wave enhanced water splitting reaction with methanol as a sacrificial material
Authors: Wang Sixuan , Herrmann Rudolf , Reiner Alexander , Wixforth Achim , Westerhausen Christoph
Published: December 2020

Surface acoustic waves double the photocatalytic activity of platinum-doped titanium dioxide for water splitting with methanol as a sacrificial material.
Identification of hydrogen species on Pt/Al2O3 by in situ inelastic neutron scattering and their reactivity with ethylene
Authors: Yamazoe Seiji , Yamamoto Akira , Hosokawa Saburo , Fukuda Ryoichi , Hara Kenji , Nakamura Mitsutaka , Kamazawa Kazuya , Tsukuda Tatsuya , Yoshida Hisao , Tanaka Tsunehiro
Published: December 2020

Active hydrogen species and their dynamics in ethylene hydrogenation reaction were elucidated by in situ INS and DFT calculations.
Thio-conjugation of substituted benzofurazans to peptides: molecular sieves catalyze nucleophilic attack on unsaturated fused rings
Authors: Verdoliva Valentina , Digilio Giuseppe , Saviano Michele , De Luca Stefania
Published: December 2020

An efficient procedure to selectively introduce benzofurazan moieties into peptides was developed. It employs zeolite to catalyze the S-conjugation reaction.
Hierarchical ISI-1 zeolite catalyst for hydroconversion of long-chain paraffins
Authors: Sree Sreeprasanth Pulinthanathu , Radhakrishnan Sambhu , Geerts Lisa , Van der Donck Tom , Vanbutsele Gina , Breynaert Eric , Seo Jin Won , Martens Johan A.
Published: December 2020

The hierarchization via desilication of ISI-1 zeolite, belonging to the TON type family and its impact on catalytic performance in hydroconversion of model long chain n-alkanes are presented.
Emerging investigator series: entrapment of uranium–phosphorus nanocrystals inside root cells of Tamarix plants from a mine waste site
Authors: Rodriguez-Freire Lucia , DeVore Cherie L. , El Hayek Eliane , Berti Debora , Ali Abdul-Mehdi S. , Lezama Pacheco Juan S. , Blake Johanna M. , Spilde Michael N. , Brearley Adrian J. , Artyushkova Kateryna , Cerrato José M.
Published: December 2020

Uranium uptake and accumulation in the roots of Tamarix plants, leading to extracellular U precipitation, and the intracellular entrapment of U–P nanocrystals.
Mechanistic study of oil adsorption onto PVP-coated magnetic nanoparticles: an integrated experimental and molecular dynamics study to inform remediation
Authors: Boateng Linkel K. , Mirshahghassemi Seyyedali , Wu Haibin , Flora Joseph R. V. , Grassian Vicki H. , Lead Jamie R.
Published: December 2020

PVP coatings on magnetic NPs are partially displaced in the presence of fulvic acid, which reduces crude oil adsorption onto the magnetite.
Early-life supplementation of grape polyphenol extract promotes polyphenol absorption and modulates the intestinal microbiota in association with the increase in mRNA expression of the key intestinal barrier genes
Authors: Lu Feng , Li Yuanyuan , Zhou Bing , Guo Qing , Zhang Yan
Published: December 2020

Early-life nutritional supplementation can dramatically influence health status.
Continuous hydrogenolysis of acetal-stabilized lignin in flow
Authors: Lan Wu , Du Yuan Peng , Sun Songlan , Behaghel de Bueren Jean , Héroguel Florent , Luterbacher Jeremy S.
Published: December 2020

We performed a steady state high-yielding depolymerization of soluble acetal-stabilized lignin in flow, which offered a window into challenges and opportunities that will be faced when continuously processing this feedstock.
Cross-linking behavior of eutectic hardeners from natural acid mixtures
Authors: Tellers Jonathan , Jamali Mona , Willems Philippe , Tjeerdsma Bôke , Sbirrazzuoli Nicolas , Guigo Nathanael
Published: December 2020

Eutectic hardeners were prepared using mixtures of natural acids and liquefactor for increasing the curing speed and for improving the mechanical performances of biobased thermosets.
Microfluidic electrosynthesis of thiuram disulfides
Authors: Zheng Siyuan , Wang Kai , Luo Guangsheng
Published: December 2020

A microfluidic electrosynthesis method, which works with high efficiency in a flow chemistry system, for thiuram disulfides is proposed in order to avoid the generation of over-oxidation by-products and waste salts.
Rapid sample preparation for detection of antibiotic resistance on a microfluidic disc platform
Authors: Perebikovsky Alexandra , Liu Yujia , Hwu Alexander , Kido Horacio , Shamloo Ehsan , Song Dian , Monti Gabriel , Shoval Oren , Gussin Daniel , Madou Marc
Published: December 2020

We demonstrated a novel instrument and a centrifugal microfluidics disc design that is capable of remarkably accomplishing the sample treatment steps, which pave the way to realize the antibody susceptibility test in point-of-care situation.
Plasmonic triangular nanoprism sensors
Authors: Otsuki Joe , Sugawa Kosuke , Jin Shota
Published: December 2020

This review gives a one-stop account of LSPR sensors using Au and Ag nanoprisms from basic physics to recent applications.
Deacylcortivazol-like pyrazole regioisomers reveal a more accommodating expanded binding pocket for the glucocorticoid receptor
Authors: Zimmerman Jessica A. O. , Fang Mimi , Doumbia Bintou , Neyman Alexis , Cha Ji Hyeon , Thomas Michael , Hall Bonnie , Wu Meng , Wilson Anne M. , Pufall Miles A.
Published: December 2020

Ullmann-like synthesis of deacylcortivazol-like regioisomers reveals a broader than expected structure activity relationship for novel glucocorticoids.
A second generation of 1,2,4-oxadiazole derivatives with enhanced solubility for inhibition of 3-hydroxykynurenine transaminase (HKT) from Aedes aegypti
Authors: Maciel Larissa G. , Barbosa Andrey da S. , de Alencar-Filho Edilson B. , Soares Thereza A. , dos Anjos Janaína V.
Published: December 2020

Water-soluble oxadiazole-based HKT inhibitor library, comprising a new class of compounds for control of Aedes aegypti dissemination, act as competitive HKT enzyme inhibitors, promoting accumulation of the toxic metabolite 3-hydroxykynurenine in insect organism.
A detailed computational study on binding of kinase inhibitors into β-cyclodextrin: inclusion complex formation
Authors: Faraj Pour Mojdehi Maryam , Ganjali Koli Mokhtar , Dolatkhah Ouch Bolagh Mahsa , Ghane Gardeh Mina , Hashemianzadeh Seyed Majid
Published: December 2020

It is well known that the limited aqueous solubility of some drugs often reduces their bioavailability to targets.
Sensing arbitrary contact forces with a flexible porous dielectric elastomer
Authors: Nie Baoqing , Geng Jialei , Yao Ting , Miao Yihui , Zhang Yiqiu , Chen Xinjian , Liu Jian
Published: December 2020

Artificial tactile sensing in next-generation robots requires the development of flexible sensors for complicated tactile force measurements in both normal and tangential directions.
Polarity control of DNA adsorption enabling the surface functionalization of CuO nanozymes for targeted tumor therapy
Authors: Meng Yingcai , Chen Yuan , Zhu Jiaojiao , Qi Yan , Ding Jinsong , Zhou Wenhu
Published: December 2020

A di-block DNA was designed to surface functionalize CuO nanozyme with high biological stability and targetability for nano-catalytic tumor therapy.
Niobium pentoxide based materials for high rate rechargeable electrochemical energy storage
Authors: Shen Fei , Sun Zhongti , He Qinggang , Sun Jingyu , Kaner Richard B. , Shao Yuanlong
Published: December 2020

This review summarizes the crystalline features, electrochemical characteristics, ions intercalation charge storage mechanisms, and recent advances in niobium pentoxide related materials for high-rate electrochemical energy storage.
Patterning and control of the nanostructure in plasma thin films with acoustic waves: mechanicalvs.electrical polarization effects
Authors: García-Valenzuela Aurelio , Fakhfouri Armaghan , Oliva-Ramírez Manuel , Rico-Gavira Victor , Rojas Teresa Cristina , Alvarez Rafael , Menzel Siegfried B. , Palmero Alberto , Winkler Andreas , González-Elipe Agustín R.
Published: December 2020

Plasma thin film deposition assisted with acoustic waves renders a patterned structure due to sheath ions local bombardment effects.
Layer-dependent ferroelectricity in 2H-stacked few-layer α-In2Se3
Authors: Lv Baohua , Yan Zhi , Xue Wuhong , Yang Ruilong , Li Jiayi , Ci Wenjuan , Pang Ruixue , Zhou Peng , Liu Gang , Liu Zhongyuan , Zhu Wenguang , Xu Xiaohong
Published: December 2020

Layer-dependent ferroelectric polarization in 2H-stacked α-In2Se3attributed to a 180 degree in-plane rotation in the adjacent layers is reported.
Glycomics & Glycoproteomics: From Analytics to Function
Authors: Thaysen-Andersen Morten , Kolarich Daniel , Packer Nicolle H.
Published: December 2020

Morten Thaysen-Andersen, Daniel Kolarich and Nicolle H. Packer introduce the Molecular Omics themed issue on Glycomics & Glycoproteomics: From Analytics to Function.
Tuning the coalescence degree in the growth of Pt–Pd nanoalloys
Authors: Nelli Diana , Cerbelaud Manuella , Ferrando Riccardo , Minnai Chloé
Published: December 2020

Combined theoretical and experimental investigations of Pt–Pd nanoalloys grown by magnetron sputtering in the gas phase show that the coalescence degree can be controlled and unravel the key atomic-level mechanisms.
[1,2,4]Triazolo[4,3-a]quinoxaline and [1,2,4]triazolo[4,3-a]quinoxaline-1-thiol-derived DNA intercalators: design, synthesis, molecular docking, in silico ADMET profiles and anti-proliferative evaluations
Authors: El-Adl Khaled , El-Helby Abdel-Ghany A. , Sakr Helmy , Elwan Alaa
Published: December 2020

In view of their DNA intercalation activities as anticancer agents, 17 novel [1,2,4]triazolo[4,3-a]quinoxaline derivatives have been designed, synthesized and evaluated against HepG2, HCT-116 and MCF-7 cells.
Low-cost air-stable perovskite solar cells by incorporating inorganic materials
Authors: Heshmati N. , Mohammadi M. R. , Abachi P. , Martinez-Chapa S. O.
Published: December 2020

Herein, we demonstrate a new fabrication strategy for low-cost and stable-operation perovskite solar cells (PSCs) suitable for commercialization.
Ultrasensitive simultaneous detection of ascorbic acid, dopamine, uric acid and acetaminophen on a graphitized porous carbon-modified electrode
Authors: Duraisamy Velu , Sudha Velayutham , Annadurai Kuppusamy , Senthil Kumar Sakkarapalayam Murugesan , Thangamuthu Rangasamy
Published: December 2020

NHCS-1000/GCE produces a noticeable electrocatalytic response towards the anodic oxidation for the multiple sensing of AA, DA, UA and AC.
Plasma-induced black bismuth tungstate as a photon harvester for photocatalytic carbon dioxide conversion
Authors: Zhong Kang , Zhou Anqi , Zhou Guli , Li Qidi , Yang Jinman , Wang Zhaolong , Zhu Xingwang , Qian Junchao , Hua Yingjie , Li Huaming , Xu Hui
Published: December 2020

The Bi QDs are reduced in situ on the surface of black Bi2WO6 nanosheets using a novel plasma treatment, which shows a superior CO2 conversion performance.
A cage compound precursor-derived Sb/Sb2O4/Fe3C nanocomposite anchored on reduced graphene oxide as an anode for potassium ion batteries
Authors: Wang Jianwen , Cao Mengyang , Xu Feng , Zhu Xiuli , Rashid Khan , Wang Yan , Huang Lu
Published: December 2020

A cage compound precursor-derived Sb/Sb2O4/Fe3C nanocomposite anchored on reduced graphene oxide is fabricated and used as an anode for PIBs and delivers an outstanding electrochemistry performance.
N-Substituted tetrahydropentaazadibenzocycloheptafluorenes – a new type of condensed polyazapolycyclic system
Authors: Rakhimova Elena B. , Kirsanov Victor Yu. , Mescheryakova Ekaterina S. , Khalilov Leonard M. , Ibragimov Askhat G.
Published: December 2020

Ni-Catalyzed heterocyclization of octahydro-2,2′-biquinazoline with 1,3,5-triazinanes is an efficient synthetic route to mono-N-substituted tetrahydro-4b,5a,10b,12,13a-pentaazadibenzo[a,h]-cyclohepta[1,2,3,4-def]fluorenes.
The in situ construction of three-dimensional core–shell-structured TiO2@PPy/rGO nanocomposites for improved supercapacitor electrode performance
Authors: Li Shiyun , Zhang Ling , Zhang Luxi , Zhang Jiaoxia , Zhou Haijun , Chen Xuecheng , Tang Tao
Published: December 2020

Three-dimensional core–shell-structured TiO2@PPy/rGO nanocomposites can be used as ideal electrodes with a longer discharge time and higher capacitance.
Dispersant-assisted liquid-phase exfoliation of 2D materials beyond graphene
Authors: Hu Chen-Xia , Shin Yuyoung , Read Oliver , Casiraghi Cinzia
Published: December 2020

Dispersant-assisted liquid-phase exfoliation allows the production of a wide range of water-based 2D material dispersions. This review provides an overview on this production method and also gives some perspectives on future research directions.
Highly flexible and degradable memory electronics comprised of all-biocompatible materials
Authors: Jiang Tongfen , Meng Xianghao , Zhou Zhe , Wu Yueyue , Tian Zhihui , Liu Zhengdong , Lu Gang , Eginlidil Mustafa , Yu Hai-Dong , Liu Juqing , Huang Wei
Published: December 2020

A flexible and degradable memory electronic comprising all-biocompatible materials is reported, which exhibited nonvolatile data storage ability, and was promising as an eco-firendly memory electronic.
A nitrogen-doped NiCo2S4/CoO hollow multi-layered heterostructure microsphere for efficient oxygen evolution in Zn–air batteries
Authors: He Bin , Song Juan-Juan , Li Xiao-Yu , Xu Chun-Yu , Li Yi-Bo , Tang Ya-Wen , Hao Qing-Li , Liu Hong-Ke , Su Zhi
Published: December 2020

Exploring highly effective and low-cost non-noble metal-based electrocatalysts for oxygen evolution reaction (OER) is critical for renewable energy conversion and metal–air batteries.
HA targeted-biodegradable nanocomposites responsive to endogenous and exogenous stimulation for multimodal imaging and chemo-/photothermal therapy
Authors: Wang Hai-Yan , Zhang Yan , Ren Xing-Hui , He Xi-Wen , Li Wen-You , Zhang Yu-Kui
Published: December 2020

A tumor-targeted, on-demand chemo-/photothermal therapeutic nanoplatform (HIDSiGdNPs@PDA-HA) based on degradable HMONs was used for bimodal imaging and endogenous and exogenous multi-factor stepwise response for drug release and treatment.
Transporting mitochondrion-targeting photosensitizers into cancer cells by low-density lipoproteins for fluorescence-feedback photodynamic therapy
Authors: Wang Chao , Zhao Xianhao , Jiang Haoyu , Wang Jiaxin , Zhong Weixiu , Xue Ke , Zhu Chunlei
Published: December 2020

Low-density lipoproteins (LDLs) reconstituted with a multifunctional mitochondrion-targeting photosensitizer are able to achieve fluorescence-feedback photodynamic therapy of LDL receptor-overexpressing cancer cells.
Triplet energy migration pathways from PbS quantum dots to surface-anchored polyacenes controlled by charge transfer
Authors: Zhao Guohui , Chen Zongwei , Xiong Kao , Liang Guijie , Zhang Jianbing , Wu Kaifeng
Published: December 2020

Kinetic pathways of triplet energy transfer from photoexcited PbS QDs to surface-anchored tetracene and pentacene derivatives are dictated by charge-transfer energetics at the QD/molecule interface.
Biocatalytic synthesis of non-vicinal aliphatic diols
Authors: Ebrecht Ana C. , Aschenbrenner Jasmin C. , Smit Martha S. , Opperman Diederik J.
Published: December 2020

Regioselective biocatalytic oxyfunctionalization of n-alkanes for the production of non-vicinal diols through sequential oxygenation by a cytochrome P450 monooxygenase.
The chemistry and biology of fungal meroterpenoids (2009–2019)
Authors: Jiang Minghua , Wu Zhenger , Liu Lan , Chen Senhua
Published: December 2020

The structural features, biological activities, and fungal biodiversity of 1585 new meroterpenoids were comprehensively overviewed (2009–2019).
Synthesis of thioamide containing polybenzoxazines by the Willgerodt–Kindler reaction
Authors: Bayram Kamer , Kiskan Baris , Yagci Yusuf
Published: December 2020

Benzoxazines with thioamide linkages were successfully prepared by the Willgerodt–Kindler route.
A bio-based low dielectric material at a high frequency derived from resveratrol
Authors: Huang Gang , Fang Linxuan , Wang Caiyun , Dai Menglu , Sun Jing , Fang Qiang
Published: December 2020

An efficient strategy to design and synthesize a low dielectric material at a high frequency of 5 GHz derived from renewable resveratrol.
Amphiphilic random and random block terpolymers with PEG, octadecyl, and oleyl pendants for controlled crystallization and microphase separation
Authors: Imai Sahori , Ommura Yasuyuki , Watanabe Yuki , Ogawa Hiroki , Takenaka Mikihito , Ouchi Makoto , Terashima Takaya
Published: December 2020

Amphiphilic random and random block terpolymers bearing PEG chains, crystalline octadecyl groups, and amorphous oleyl groups were designed to control crystallization and microphase separation in the solid state.
Turn-on fluorescent probe towards glyphosate and Cr3+ based on Cd(ii)-metal organic framework with Lewis basic sites
Authors: Wiwasuku Theanchai , Boonmak Jaursup , Burakham Rodjana , Hadsadee Sarinya , Jungsuttiwong Siriporn , Bureekaew Sareeya , Promarak Vinich , Youngme Sujittra
Published: December 2020

Lewis basic site-functionalized porous Cd(ii)-MOF as a bi-functional fluorescent sensor of glyphosate and Cr3+ with exceptional LODs.
Solid-stateversussolution investigation of a luminescent chiral BINOL-derived bisphosphate single-molecule magnet
Authors: Mattei Carlo Andrea , Montigaud Vincent , Gendron Frédéric , Denis-Quanquin Sandrine , Dorcet Vincent , Giraud Nicolas , Riobé François , Argouarch Gilles , Maury Olivier , Le Guennic Boris , Cador Olivier , Lalli Claudia , Pointillart Fabrice
Published: December 2020

The enantiopure coordination polymer [Dy(hfac)3((S/R)-L)]n([(S/R)-1]n) involving a BINOL-derived bisphosphate ligand(S/R)-Lis investigated both in solution and solid-state.
Highly enhanced H2 evolution of MoO3/g-C3N4 hybrid composites based on a direct Z-scheme photocatalytic system
Authors: Li Kunqiao , Wu Wanbao , Jiang Yanqiu , Wang Zhe , Liu Xing , Li Junzhuo , Xia Debin , Xu Xianzhu , Fan Jizhuang , Lin Kaifeng
Published: December 2020

A direct Z-scheme MoO3/g-C3N4 heterojunction with appropriate oxygen vacancies is successfully fabricated via an in situ method of a one-pot pyrolysis strategy.
Kinetics of the reaction of H2 with Pt0-nanoparticles in aqueous suspensions monitored by the catalytic reduction of PW12O403−
Authors: Vijay Aswin Kottapurath , Meyerstein Dan , Marks Vered , Albo Yael
Published: December 2020

The mechanism of the reaction between Pt0 nanoparticles and Hydrogen was measured in the absence of an electric field via following the formation of PW12O404−/5−.
A dual-protection strategy using CMK-3 coated selenium and modified separators for high-energy Al–Se batteries
Authors: Lei Haiping , Tu Jiguo , Song Wei-Li , Jiao Handong , Xiao Xiang , Jiao Shuqiang
Published: December 2020

Al–Se batteries designed by a dual-protection strategy greatly block the intermediate products dissolved in the electrolyte, delivering a high capacity of 651 mA h g−1 after 400 cycles at 1000 mA g−1.
Catalytic enantioselective synthesis of indolizino[8,7-b]indole alkaloid derivatives based on the tandem reaction of tertiary enamides
Authors: Xu Xin-Ming , Xie Ming , Li Jiazhu , Wang Mei-Xiang
Published: December 2020

An exquisite Pybox/Cu(OTf)2-catalyzed asymmetric tandem reaction of tertiary enamides was developed, which enabled the expeditious synthesis of indolizino[8,7-b]indole derivatives in high yield, excellent enantioselectivity and diastereoselectivity.
Highly regio- and stereoselective synthesis of bis-sulfanyl substituted conjugated dienes by copper–palladium cooperative catalysis
Authors: Li Yuan , Wu Jin , Li Hui , Sun Qian , Xiong Lixue , Yin Guodong
Published: December 2020

An efficient one-pot method for the synthesis of (Z,Z)-isomers of 1,4-bis(sulfanyl)-1,4-diaryl-1,3-butadienes by the cooperative catalysis of Cu(Xantphos)I/Pd(OAc)2 and a base has been developed.
Iron-catalyzed hydrogen atom transfer induced cyclization of 1,6-enynes for the synthesis of ketoximes: a combined experimental and computational study
Authors: Zhao Mingming , He Wei , Zou Liang-Hua , Wang Dawei , Sun Tian-Yu , Xia Xiao-Feng
Published: December 2020

An iron-catalyzed reductive radical cyclization/hydro-oximation of 1,6-enynes withtBuONO was developed, leading to functionalized benzofuran, benzothiophene, and cyclopentenyl-based ketoximes.
Switchable and efficient conversion of 2-amido-aryl oxazolines to quinazolin-4(3H)-ones and N-(2-chloroethyl)benzamides
Authors: Chen Weiqiang , Liu Mei , Li Hui-Jing , Wu Yan-Chao
Published: December 2020

Switchable chemoselective conversion of 2-amido-aryl oxazolines to quinazolin-4(3H)-ones or N-(2-chloroethyl)benzamides is achieved.
Remote methylene C(sp3)–H functionalization enabled by organophosphine-catalyzed alkyne isomerization
Authors: Wang De , Song Zefeng , Zhang Jianyu , Xu Tao
Published: December 2020

Non classical EWG-activated arylalkynes as C1 units in organophosphine catalyzed diverse remote sp3 C–H functionalization.
Selective deposition of gold particles onto silicon at the nanoscale controlled by a femtosecond laser through galvanic displacement
Authors: Wang Yuhui , Liu Wei , Li Chen , Jiang Lan , Hu Jie , Ma Yunlong , Wang Suocheng
Published: December 2020

Control of the deposition location and morphology of metals on semiconductors is of considerable importance for the fabrication of metal–semiconductor hybrid structures.
Preparation and in vitro characterization of valsartan-loaded ethyl cellulose and poly(methyl methacrylate) nanoparticles
Authors: Hajba-Horváth Eszter , Biró Emese , Mirankó Mirella , Fodor-Kardos Andrea , Trif László , Feczkó Tivadar
Published: December 2020

Valsartan-loaded ethyl cellulose and poly(methyl methacrylate) nanoparticles were prepared and nano spray-dried. The active agent was structurally changed in the nanoparticles, which could be advantageous in the intestinal absorption.
Intra-mitochondrial reaction for cancer cell imaging and anti-cancer therapy by aggregation-induced emission
Authors: Kim Sangpil , Kim Juhee , Jana Batakrishna , Ryu Ja-Hyoung
Published: December 2020

Controlled intracellular chemical reactions to regulate cellular function remain a challenge in biology mimetic systems.
Gut microbiota-mediated tributyltin-induced metabolic disorder in rats
Authors: Yuan Ge-hui , Zhang Zhan , Gao Xing-su , Zhu Jun , Guo Wen-hui , Wang Li , Ding Ping , Jiang Ping , Li Lei
Published: December 2020

Tributyltin (TBT), an environmental pollutant widely used in antifouling coatings, can cause multiple-organ toxicity and gut microbiome dysbiosis in organisms, and can even cause changes in the host metabolomic profiles.
Cationic gemini surfactant stimulates amyloid fibril formation in bovine liver catalase at physiological pH. A biophysical study
Authors: Khan Javed Masood , Malik Ajamaluddin , Rehman Md. Tabish , AlAjmi Mohamed F. , Ahmed Mohammad Z. , Almutairi Ghada Obaid , Anwer Md. Khalid , Khan Rizwan Hasan
Published: December 2020

Surfactant molecules stimulate amyloid fibrillation and conformational switching in proteins but the mechanisms by which they accomplish these effects are unclear.
Efficiency of liquid tin(ii)n-alkoxide initiators in the ring-opening polymerization ofl-lactide: kinetic studies by non-isothermal differential scanning calorimetry
Authors: Sriyai Montira , Chaiwon Tawan , Molloy Robert , Meepowpan Puttinan , Punyodom Winita
Published: December 2020

The efficiency of homogeneous liquid tin(ii)n-alkoxide initiators in the ROP ofl-lactide was reported in this work by non-isothermal DSC kinetic approaches.
Chemically stable new MAX phase V2SnC: a damage and radiation tolerant TBC material
Authors: Hadi M. A. , Dahlqvist M. , Christopoulos S.-R. G. , Naqib S. H. , Chroneos A. , Islam A. K. M. A.
Published: December 2020

Using density functional theory, the phase stability and physical properties, including structural, electronic, mechanical, thermal and vibrational with defect processes, of a newly synthesized 211 MAX phase V2SnC are investigated for the first time.
Ultrafast-charging and long cycle-life anode materials of TiO2-bronze/nitrogen-doped graphene nanocomposites for high-performance lithium-ion batteries
Authors: Autthawong Thanapat , Chimupala Yothin , Haruta Mitsutaka , Kurata Hiroki , Kiyomura Tsutomu , Yu Ai-shui , Chairuangsri Torranin , Sarakonsri Thapanee
Published: December 2020

The TiO2-bronze/nitrogen-doped graphene nanocomposites have the potential for fast-charging and have high stability, showing potential as an anode material in advanced power batteries for next-generation applications.
Comparison of Fe2TiO5/C photocatalysts synthesized via a nonhydrolytic sol–gel method and solid-state reaction method
Authors: Zhao Qianqian , Feng Guo , Jiang Feng , Lan Shanfang , Chen Junhua , Liu Mengting , Huang Zuzhi , Liu Jianmin , Hu Qing , Jiang Weihui
Published: December 2020

Two different methods were used to prepare Fe2TiO5/C photocatalysts, demonstrating the superiorities of in situ carbon introduced by a NHSG method.
Comprehensive DFT investigation of transition-metal-based new quaternary Heusler alloys CoNbMnZ (Z = Ge, Sn): compatible for spin-dependent and thermoelectric applications
Authors: Seh Ab Quyoom , Gupta Dinesh C.
Published: December 2020

Possible d–d hybridization for characterizing the electronic profile of the materials.
Cleavage of aryl–ether bonds in lignin model compounds using a Co–Zn-beta catalyst
Authors: Dou Xiaomeng , Li Wenzhi , Zhu Chaofeng , Jiang Xiao , Chang Hou-min , Jameel Hasan
Published: December 2020

The catalytic hydrogenolysis of lignin model compounds containing aryl–ether linkages by Co–Zn-beta catalyst is investigated to understand the role of “Lewis acid-metal” catalysts in lignin depolymerization.