bluuebunny/crossref_metadata_2025 huggingface dataset:
Indexes of innate and adaptive immunity in the patients with SARS-CoV-2 infection
Authors: Sitdikova T. S. , Kabieva A. A. , Prosekova E. V.
Published: April 2022

The main pathogenetic mechanisms of the SARS-CoV-2 infection include imbalance of immune response and impaired cytokine regulation involving insufficient interferon synthesis at the onset of the disease, and subsequent hyperproduction of proinflammatory cytokines resulting in marked inflammation and damage of pulmonary parenchyma. Our objective was to perform monitoring of cytokine content, determination of antibodies, immune cells, and inflammatory biomarkers in the patients who had coronavirus infection caused by COVID-19, during the disease and over the convalescence period. The study included sixty patients at the age of 18 y.o. and older with severe and moderate course of disease caused by COVID-19. The diagnosis was verified in accordance with provisional instructional guidelines of the Ministry of Healthcare of the Russian Federation “Prevention, diagnosis and treatment of novel coronavirus infection (COVID-19)” version 11 (17.05.2021). The study involved analysis of medical documents, evaluation of differential white blood cell count, T cell subpopulations, C-reactive ptrotein (CRP) levels, interleukin-6 (IL-6), interferon gamma (IFNγ), tumor necrosis factor-alpha (TNFα), as well as IgM and IgG antibodies against SARS-CoV-2.Statistical processing of data was performed by Statistica 13 program with critical significance level p 0.05, correlations were analyzed using Spearman rank correlation coefficient, multidimensional correlation analysis with creation of pleiads, according to V.P. Terentyev’s method (1959), and Shapiro–Wilk testing for normality of data distributions. The sample size made it possible to evaluate the results at a significance of 95-99%. These studies have yielded the results concerning specific changes of the inflammatory biomarkers at different stages of disease, persistent changes in quantitative and qualitative characteristics of immune cells and cytokine levels, correlations between immunological indicators and severity of clinical course, and degree of damage to pulmonary parenchyma. During the period of significant clinical presentations, the patients with severe course of disease exhibited leukopenia with low proportion of lymphocytes, and maintenance of CRP and ESR at high levels for longer terms, including early recovery. Levels and changes in amounts of IgG and IgM antibodies to SАRS-CoV-2 varied in accordance with clinical severity and duration of convalescence period. During the recovery period, an imbalance of regulatory T cell subpopulations and low levels of IFNγ were observed. The stable impairment of structural and functional characteristics of immune cells and aberrant production of cytokines during the disease caused by SARS-CoV-2 may serve as a pre-requisite for monitoring immunological indices in search for personalized immunotropic therapy.
Extended haplotypes based on rare single nucleotide polymorphisms of TNFA and HLA DRB1 associated with rheumatoid arthritis
Authors: Stashkevich D. S. , Khromova E. B. , Devald I. V. , Khodus E. A. , Burmistrova A. L.
Published: April 2022

Rheumatoid arthritis (RA) is a multifactorial disease, with genetic component based on intergenic interactions leading to the formation of gene networks. The current trend in RA immunogenetic studies is to assess the gene-to-gene interactions. Among possible genetic factors contributing to RA development, the genes of main histocompatibility complex (HLA class II) play a fundamental role. TNFA gene is among possible candidate genes providing susceptibility to this disorder and contributing to its immune pathogenesis. The special location of this gene suggests arrangement of extended TNFA – HLA haplotypes. This work analyzed the distribution features of two-locus SNP haplotypes (TNFA and HLA DRB1) for their association with rheumatoid arthritis in Russians. The following methods were used: DNA isolation, PCR-based genotyping, RFLP analysis with electrophoretic detection. Calculation of two-locus haplotypes frequencies and linkage disequilibrium (D’; χ2; p) was carried out using the EM algorithm in the Arlequin ver 3.5 program. Comparison of paired samples was carried out using standard immunogenetic criteria. The significance level was 0.05. Analysis of the data showed that the two-locus haplotypes -1031T/C and -863C/A TNFA were not associated with predisposal for rheumatoid arthritis in Russian population sample. The haplotypes associated with predisposition for RA were TNFA -863*a – HLA DRB1*03, TNFA -1031*t – HLA DRB1*04, TNFA -1031*t – HLA DRB1*04. Meanwhile, TNFA -1031*t – HLA DRB1*15; TNFA -1031*t -HLA DRB1*11 proved to be protective haplotypes. Our study showed that, in addition to individual HLA II alleles, the predisposal or resistance to rheumatoid arthritis may be promoted by haplotypes of rare SNPs at positions -1031, -863 C/A of TNFA gene, and HLA DRB1.
Production of growth factors, pro – and anti-inflammatory cytokines by postnatal MMSCs from various tissue sources during in vitro co-cultivation with immunoisolated pancreatic β-cells
Authors: Goncharov A. G. , Shupletsova V. V. , Todosenko N. M. , Goncharova E. A. , Litvinova L. S.
Published: April 2022

The article presents the results of evaluating growth factors, pro – and anti-inflammatory cytokine production by multipotent mesenchymal stem cell cultures under the conditions of co-cultivation with immuno-isolated beta-cells of the pancreas. β-cell transplantation is a minimally invasive therapeutic approach (compared to transplantation of entire pancreas), and it provides better metabolic control with respect to insulin administration. However, when transplanting β-cells, there is always a risk of immune rejection of the grafted cells. It is generally recognized that encapsulation is an effective means of immunological protection against the recipient’s immune system during transplantation. Regulation of the autoimmune response to transplanted cells is crucial for the treatment of type I diabetes mellitus. In recent years, along with replacement of islet cells, much attention has been paid to the use of multipotent mesenchymal stem cells with immunomodulatory and/or immunosuppressive properties, aimed for the correction of diabetes mellitus. Either in vitro and in vivo, they impact not only T-lymphocytes, but also B-lymphocytes, dendritic and NK-cells. Mesenchymal stem cells are able to inhibit proliferation of immune cells and reduce their secretion of inflammatory cytokines, acting as auxiliary cells to improve the survival of islets in the early post-transplant phase. Combined transplantation of multipotent mesenchymal stem cells and pancreatic β-cells is a promising approach to the treatment of type I diabetes mellitus. Deeper study of the mechanisms that cause their cytoprotective effect upon the transplant may be helpful for implementation of this therapeutic approach and improve its efficiency. In our study, a 1% solution of low-viscosity sodium alginate with addition of saline solution (0.9% sodium chloride) was used to create immuno-insulating scaffolds, and a 2.2% BaCl2 solution was added for polymerization. Decreased production of proinflammatory cytokines (TNFα, IL-12, IL-5) and growth factor (GM-CSF) was registered in co-cultures of β-cells with mesenchymal stem cells of bone marrow origin, and those obtained from subcutaneous adipose tissue. Anti-inflammatory activity was more pronounced in adipose stem cells and their immunomodulatory effects were shown via changes of their cytokine-producing activity. Hence, the multipotent mesenchymal stem cells obtained from adipose tissue and bone marrow have shown to exert cytoprotective effect upon pancreatic beta-cells by shifting the cytokine-producing activity towards an antiinflammatory profile.
Peripheral molecular messages – cytokines and stress hormones – in the context of cognitive aging phenotypes: healthy ageing/depression/dementia
Authors: Burmistrova A. L. , Cazaux M. E. , Alekseeva A. S. , Filippova Yu. Yu.
Published: April 2022

Over last years, the world’s aging populations are rising rapidly, and the phenotypes of cognitive insufficiency, such as old age, depression and dementia, are increasing. Search for approaches to discrimination between such phenotypes is extremely relevant. Current studies present compelling evidence of the key role of immune system (its peripheral compartment), and the stress response system in physiological brain health. Therefore, assessment of complex interactions between immune and neuroendocrine systems may be an effective way to differentiate between depression and early stages of dementia in elderly people. Our purpose was to reveal peripheral molecular messages, e.g., cytokines and stress hormones, in the context of cognitive impairment phenotypes: healthy old age/old age depression/dementia. Eighty elderly people were included into groups as follows: “Healthy ageing”, “Dementia”, “Depression”. Levels of certain cytokines: IL-6, IL-1β, TNFα, IFNγ, IL-10, and stress hormones (cortisol, ACTH, dopamine, noradrenaline, and adrenaline) were determined in blood plasma by ELISA. The intergroup differences were evaluated by the Kruskal-Wallis test with Conover-Inman post-hoc pairwise comparisons. For differential diagnostics between the groups of elderly people with varying grades of cognitive impairment, we used linear canonical discriminant analysis performed on the ranks. It has been shown that cognitive insufficiency phenotypes—old age depression and dementia—differ from the healthy ageing phenotype with their high peripheral levels of TNFα cytokine and low levels of IL-1β. The differences between depression in elderly and dementia included lower level of IL-10 in depression (lower than in “Healthy ageing”), and high IL-6 in dementia (compared to “Healthy ageing”). Evaluation of the hypothalamic-pituitary and sympatho-adreno-medullary axes hormones showed hyporesponsiveness of hypothalamic-pituitary axis, regardless of cognitive insufficiency phenotypes, along with activation of sympatho-adreno-medullary axis, i.e., high dopamine level in old age depression with dementia, and high adrenaline level in dementia, than in depression of elderly phenotype and healthy ageing. Such significant differences in the levels of molecular messages, i.e., cytokines and stress hormones among the old age person groups, enabled diagnostic efficacy of 87.5% to differentiate cognitive phenotypes of aging: healthy ageing, old age depression, and dementia.
Evaluation of tissue factor expression on monocytes in the patients with sepsis
Authors: Lazanovich V. A. , Markelova E. V. , Shumatov V. B. , Postnova B. E.
Published: April 2022

Sepsis is nearly always associated with some type of haemostatic disorder. The factors that play main causal role in pathogenesis of these processes are pro-inflammatory cytokines, vascular endothelium, platelets, leukocytes, and tissue factor (TF) expressed on these cells, which is always in an active state. Given a potential relationship between the blood clotting and pathophysiology of sepsis, TF may be considered a biomarker for early diagnosis, risk stratification, and prognosis of disease outcome in sepsis. Objective – to study quantitative content (CD14+CD142+) and the levels of TF expression on monocytes in the patients with sepsis, to analyze the dependence of these parameters on the severity of multiple organ dysfunction according to the SOFA scale, and disease outcomes.67 patients with sepsis were examined. The severity of multiple organ dysfunction/failure was assessed by means of the SOFA score (Sepsis-related Organ Failure Assessments, Sequential Organ Failure Assessment). All the patients were divided in 2 groups based on the severity of their condition and extent of organ failure. Group 1 (n = 30) included the patients diagnosed with sepsis and severe organ dysfunction of 6 points on the SOFA scale; Group 2 (n = 37) consisted of the patients with sepsis and organ dysfunction of 6 points according to the SOFA scores. Blood sampling from patients was made within initial 48 hours after admission and diagnosis. Quantitative content (CD14+CD142+) and the level of expression of tissue factor on monocytes were investigated by flow cytometry. We have found that the content of (CD14+CD142+) cells was significantly higher in patients with sepsis than in healthy individuals (6.03±1.05% vs 0.24±0.02%, p = 0.001), being higher in more severe organ dysfunction (SOFA) vs less severe cases (SOFA) (6.50±0.98% versus 4.42±0.36%, p = 0.05). High level of TF expression on monocytes showed a direct correlation (r 0.71; p = 0.05) with severity of organ dysfunction (SOFA), and it was associated (p = 0.004) with lethal outcome of the disorder. These results suggest that expression of tissue factor on monocytes can serve as a biomarker reflecting the degree of systemic inflammation in sepsis, thus being a criterion for predicting clinical severity and outcome of the disease in patients with sepsis.
Personalized approach to diagnostics and therapy of patients with psoriasis
Authors: Barilo A. A. , Smirnova S. V.
Published: April 2022

Establishing causal relationship between allergy and psoriasis and determining appropriate sensitization profile may guide clinicians in terms of specific allergological diagnostics and personalized therapy. Our purpose was to study the occurrence of food allergy and certain sensitization profile to food allergens in patients with psoriasis, in order to establish new approaches to specific diagnosis and treatment of the disorder.The study involved patients with psoriasis vulgaris (n = 51) aged 18 to 66 years. The control group included practically healthy people matched by sex and age (n = 19). All the patients underwent allergological examination: collection of allergic history, determination of total immunoglobulin E (IgE) and eosinophilic cationic protein concentration in blood serum by means of indirect immunofluorescence analysis using Thermo Scientific Multiskan FC semi-automatic analyzer. The sensitization profiles to food and pollen allergens were also studied. Calculation and analysis of these data was carried out using Statistica 8.0 software package.Concentration of total immunoglobulin E in blood serum in the group of patients with psoriasis was 57.9 IU/ml (31.6-135.1) compared to control group, with 45.1 IU/ml (23.4-144.0). The levels of serum eosinophilic cationic protein was 8.6 ng/ml (4.6-20.3) in the patients with psoriasis, being 7.9 ng/ml (4.6-27.1) in controls. When studying the spectrum of sensitization to food allergens in patients with psoriasis, some specific features were revealed. E.g., sensitization to cow’s milk was detected in 33.3% (n = 17); to beef, in 39.2% of cases (n = 20), to whole chicken egg – 29.4% (n = 15), to chicken, in 39.2% (n = 20); to wheat flour, 37.2% (n = 19); to rye flour, in 31.4% (n = 16); to rice and buckwheat, 21.6% (n = 11), to yeast, in 23.5% of the patients (n = 12). Upon administration of individual elimination diet for 1 month, we observed a decrease or complete regression of itching, decreased severity of infiltration, hyperemia and peeling in the foci of psoriatic skin lesions in 68% of the cases. Normal concentration of total immunoglobulin E and eosinophilic cationic protein in blood serum of patients with psoriasis combined with positive results of skin-prick tests and elimination effect presumes a participation of non-atopic immune pathologies when triggering allergy in psoriatic disease.
Metabolic therapy of predicted complications in immunocompromised recipients before repeated corneal transplantation
Authors: Komakh Yu. A. , Borzenok S. A. , Petrichuk S. V. , Kuptsova D. G. , Radigina T. V.
Published: April 2022

One of the topical problems of modern ophthalmotransplantology is the graft engraftment after repeated keratoplasty. During repeated corneal transplantation, the frequency of graft rejection increases significantly. The study included 121 patients aged 19 to 89 years with corneal graft failure, who were scheduled for repeated corneal transplantation. Immunophenotyping of major and small populations of peripheral blood lymphocytes was performed by flow cytometry (CytoFlex BC, USA). The intensity of energy metabolism in lymphocyte populations was determined by the activity of succinate dehydrogenase and NADH dehydrogenase by immunocytochemical method using flow cytometry. An increase in the content of B lymphocytes (p = 0.004) and a decrease in Th17 lymphocytes (p = 0.013) were revealed after the use of a course of metabolic therapy. Against the background of therapy, the activity of SDH in the T lymphocyte population significantly increases (p = 0.034). In addition, in the studied populations of lymphocytes in the recipient group, against the background of metabolic therapy, the normalization of SDH activity is observed: the number of recipients with low and high enzyme activity decreases. After a course of metabolic therapy, a significant decrease in NADHDH activity was revealed (p = 0.034). Indicators of lymphocyte populations and mitochondrial enzyme activity in recipients after a course of metabolic therapy indicated a more favorable prognosis for repeated corneal transplantation. Evaluation of the results of repeated keratoplasty a year after surgery showed that 59 recipients received transparent graft engraftment, and in 62 patients the graft became cloudy in the period from 1 to 8 months after surgery. In the group of patients with transparent graft engraftment, the percentage of recipients receiving metabolic therapy was significantly higher than in the group of recipients with graft opacity (41%±2.05% vs 21%±2.91%, p 0.001). Conducting metabolic therapy before surgery reduces the number of realized unfavorable prognoses of the result of rekeratoplasty, and monitoring the activity of dehydrogenases and the content of lymphocyte populations allows us to evaluate the effectiveness of therapeutic and preventive measures in immunocompromised recipients.
Role of Traditional Therapy (Yoga) in Avabahuka (Frozen Shoulder)
Authors: Nitu Tegta  , Prerna Thakur
Published: April 2022

Frozen shoulder, the “Peri-arthritis” or “Adhesive Capsulitis” is the problem of shoulder region in which the shoulder capsule, the connective tissue surrounding the gleno-humeral joint of shoulder, becomes inflamed and stiff, greatly restrict motion and cause chronic pain. In Ayurveda there is no direct reference of frozen shoulder. But there are many problems which are related viz “Avabahuka”, “Amsa Shosha”, “Bahushosha”, “Sandhigata Kupita Vata”, Snayu Gata Kupita Vata. Among these Avabahuka has close correlation with frozen shoulder. This disease usually affects the Amsa Sandhi (shoulder joint). Acharya Sushruta and other Acharyas have considered Avabahuka as a Vataja Vikara. Amsa Shosha (wasting of shoulder) can be considered as the preliminary stage of the disease, where loss or dryness of Shleshak kapha from Amsa Sandhi occurs and hampers the movement of the arm. The most common treatment for frozen shoulder is mobility, exercises and Yoga (Asana & Pranayama). Yogic procedures are helpful in removing the stiffness of the joint. Keeping this in mind I am presenting a review article on following exercises (Suksham Vyayama- wrist movement, elbow movement, shoulder movement, neck movement, wall climbing exercise, towel stretch exercise, Chakkichalan), Asanas (Tadasana, Chakkichalanasana, Ardhakatichakrasana, Katichakrasana and Shashankasana) and Pranayama (Kapalbhati, Nadishodhana (Anulom-Vilom), Bhramari) how they help manage or prevent frozen shoulder.
Morbimortalidad en el lupus eritematoso sistémico
Authors: Alba Paula
Published: April 2022

El Lupus Eritematoso Sistémico (LES) es una enfermedad autoinmune crónica que muestra una amplia diversidad en su expresión clínica y que puede manifestarse de una forma leve hasta formas que comprometen la vida del paciente dependiendo de los órganos afectados y de los fenómenos inmunológicos presentes. La enfermedad se caracteriza por alternar períodos de actividad y de remisión o baja actividad.
Posición de la Sociedad Argentina de Reumatología por el uso del cannabis medicinal
Authors: De Reumatología Sociedad Argentina
Published: April 2022

Los cannabinoides son moléculas que han sido descubiertas el siglo pasado de la planta de la marihuana. En el siglo XX y lo que lleva del XXI, estos productos han sido utilizados predominantemente en carácter recreativo y considerados drogas ilícitas. Es escasa la información del uso médico del cannabis desde el inicio de la era científica; pero en los últimos tiempos, la utilización de derivados de la marihuana para su uso médico ha adquirido relevancia pública y mediática, así como política y jurídica.
48º Congreso Argentino de Reumatología
Authors: De Reumatología Sociedad Argentina
Published: April 2022

En nombre del equipo de la Sociedad Argentina de Reumatología, tengo el agrado de darles la bienvenida al 48º Congreso Argentino de Reumatología en la ciudad de Mar del Plata. Como es tradición, el objetivo propuesto es brindar un espacio con el más alto estándar científico y educacional así como el intercambio social entre profesionales comprometidos con la Reumatología, buscando el constante avance en la asistencia de pacientes con enfermedades reumáticas. Nuestro compromiso es continuar creciendo y mejorando, para lo cual necesitamos de la crítica y el apoyo constante de los socios desde sus filiales, que es para quienes trabajamos. Esperando durante estos cuatro días cumplir con vuestras expectativas y que disfruten del Congreso, les envío un cordial saludo.
Estudio de la evolución de la competencia acuática en bebés participantes en un programa acuático desde un enfoque socioconstructivista (Study of the evolution of the aquatic competence in babies participating in an aquatic program from a socio-construct
Authors: Pla-Campas Gil , Jiménez Verónica , Benlloch Montserrat , Martínez-Olmo Francesc
Published: April 2022

La noción de competencia acuática en la infancia es un enfoque de análisis emergente que demanda de mayor apoyo científico. El presente estudio se enmarca en el ámbito del desarrollo motor y tiene impacto en el área del aprendizaje. Mediante una aproximación cualitativa, descriptiva e intrasujeto; el estudio observa cuatro díadas bebés-adulto (n = 4) durante un programa cuatrimestral de natación para bebés. Para ello se diseña un sistema ad-hoc de categorías de observación del comportamiento motor acuático del bebé y la actividad conjunta de la díada. El sistema de categorías se diseña sin habilidades apriorísticas a observar y de acuerdo con niveles crecientes de dificultad a través de dimensiones: respiración y equilibrio. Los resultados indican que es posible observar la evolución de la competencia y describir su naturaleza social sin observar habilidades. La aproximación del estudio sugiere posibilidades emergentes de análisis de los procesos de aprendizaje y desarrollo motor. 
Abstract. The water competence in childhood is an emerging study approach that demands further scientific support. This work is framed in the field of motor development and has an impact on the study of learning. Through a qualitative, descriptive and intrasubject approach; the present study looks at four infant-adult dyads (n = 4) during a four-month baby-swimming program. Thus, an ad-hoc system of categories, built for observing the baby's water motor behaviour and the joint activity of the dyad, is used. The category system is designed without deductive skills to observe and, instead, is based on increasing levels of difficulty of aquatic motor behaviour in two dimensions: breathing and balance. Results indicate that it is possible to observe the evolution of the competence and describe it in its social nature without the observation of skills. The study suggests emerging approaches to analyse motor learning and development in other motor learning environments.
Funcionalidad motriz, estado nutricional e índices antropométricos de riesgo cardiometabólico en adolescentes chilenos de 12 a 15 años (Motor functionality, nutritional status and anthropometric cardiometabolic risk indices in Chilean adolescents between
Authors: Rodriguez - Canales Carolina , Barraza - Gómez Fernando , Hinojosa - Torres Claudio , Merellano- Navarro Eugenio
Published: April 2022

El presente estudio tiene como objetivo determinar las relaciones entre los valores de funcionalidad motriz, estado nutricional e índices antropométricos de salud en adolescentes chilenos de 12 a 15 años. Estudio de corte transversal con una muestra no probabilística y por conveniencia, con una muestra final de 384 escolares (13,04 ± 0,85 años). Todos los participantes asistieron a dos sesiones de evaluación, donde se les realizó un registro de la historia clínica y una examinación física médica. En la segunda sesión, se realizaron evaluaciones antropométricas y las pruebas consideradas en la batería Functional Movement Screen (FMS). Los resultados muestran un 46,62% de los adolescentes posee sobrepeso y/u obesidad. El score total de FMS fue de 14,29±2,85 y se encontraron diferencias significativas en el IMC (índice de masa corporal) p=0,000 y en el peso p=0,002 según dependencia administrativa. Existe una relación entre FMS y PC (Perímetro de cintura), IMC e ICE (índice cintura estatura) (r=-0,31**p<0,003, r=-0,14**p<0,004 y r=0,38**p<0,003 respectivamente). También se encontró que aquellos escolares que presentan riesgo cardio metabólico también ostentarían un mayor riesgo relacionado con una baja calidad de la funcionalidad motriz. Se concluye que los niveles elevados de parámetros antropométricos de riesgo cardiovascular en especial el exceso de peso y el elevado perímetro de cintura se relacionan con una deficiente funcionalidad motriz. Y por otra parte se generan problemáticas cardiovasculares en esta etapa de la vida sin mayor distinción de sexo y dependencia administraba de los colegios, lo cual hace ver que la mal nutrición y la falta de actividad física impacta de manera transversal a la sociedad.
Encuesta Nacional de Tendencias de Fitness en Colombia para el Año 2022 (National Survey of Fitness Trends in Colombia for 2022)
Authors: Valcarce-Torrente Manel , Arroyo-Nieto Ángela , Veiga Oscar L. , Morales-Rincón Camilo
Published: April 2022

Esta investigación tuvo como objetivo identificar y comparar las principales tendencias fitness para el año 2022 en Colombia con los resultados de la encuesta nacional realizada el año anterior y con los rankings español e internacional para el año 2022. La información fue obtenida mediante un cuestionario online, replicando la metodología desarrollada por el Colegio Americano de Medicina del Deporte en las encuestas internacionales sobre tendencias en fitness. El cuestionario se envió a 3.100 profesionales de las diferentes regiones y departamentos de Colombia obteniéndose un total 1.800 respuestas (tasa de respuesta, 58,1%, 33,3% mujeres). Los resultados sitúan en el top 5 de tendencias en Colombia: “programas de ejercicio para niños y adolescentes”, “entrenamiento en circuito”, “entrenamiento con el peso corporal”, “entrenamiento funcional” y “programas de fitness para adultos mayores”. Se encontraron 11 coincidencias con la encuesta nacional del año anterior, con diversos cambios de posición; 12 equivalencias con el ranking español y 11 con el ranking de la encuesta internacional de 2022, así como un total de 10 tendencias coincidentes entre las tres encuestas. Los resultados obtenidos subrayan el interés por la actividad física orientada a la salud y pérdida de peso, diferentes variantes y métodos de entrenamiento de fuerza, a la vez que un destacado descenso en la relevancia de las tendencias relacionadas con el uso de la tecnología.
Abstract. The aim of this research was to identify and compare the main fitness trends for the year 2022 in Colombia with the findings of the national survey conducted the previous year, and also with the Spanish and international rankings for the year 2022. The information was obtained through an online survey replicating the methodology developed by the American College of Sports Medicine in international surveys on trends in fitness. The questionnaire was sent to 3,100 professionals from different sports departments and regions of Colombia, obtaining a total of 1,800 responses (response rate of 58.1%, 33.3% female). The results place in the top 5 trends in Colombia 2022: «exercise programs for children and adolescents», «circuit training», «body weight training», «functional fitness training» and «fitness programs for older adults». Within the top 20 there are 11 trends that coincide with the national survey of the previous year, with various changes in position; 12 equivalences with the 2022 Spanish ranking and 11 with the 2022 international survey ranking, as well as a total of 10 overlapping trends among the three inquiries. The results highlight the growing interest in health-oriented physical activity and weight loss, different variants and methods of strength training, in addition to a staggering decrease in the relevance of fitness trends related to the use of technology.
A Estratégia de Saúde da Família: o papel da equipe de saúde bucal
Authors: Spezzia Sérgio
Published: April 2022

O Programa de Saúde da Família (PSF), constituiu estratégia para remodelar a maneira como a assistência era fornecida a população. A Política Nacional de Atenção Básica (PNAB) designou de Estratégia de Saúde da Família (ESF) o PSF. A ESF tinha finalidade de promover reorientação e reformulação do processo de trabalho no Sistema Único de Saúde (SUS). As equipes de saúde bucal (ESB) foram também incorporadas a ESF. O objetivo do presente trabalho foi verificar como a estratégia de saúde da família com sua equipe, que pode inclusive contar com um cirurgião dentista, pode influir no contexto dos atendimentos prestados na assistência à saúde pública. Realizou-se revisão bibliográfica com levantamento nas bases de dados: PubMED, Google Acadêmico de estudos e artigos que versavam acerca do papel da estratégia saúde da família e da inclusão concomitante das equipes de saúde bucal na performance apresentada pela assistência à saúde pública. A ESF visa obter a reorganização da Atenção Básica, levando em consideração os princípios do SUS. As funções das ESB no decorrer dos atendimentos prestados a população devem englobar a prática da interatividade com profissionais de outras áreas, no intuito de proceder-se a atuação em saúde, considerando os pacientes como um todo. A inclusão das ESB na ESF possibilitou atender a demanda dos pacientes para atendimento e possibilitou melhoria na qualidade de vida dos mesmos, permitindo a eliminação das sensações de dor desconforto provenientes de problemas odontológicos.
Educopédia: narrativas dos professores de educação física sobre a plataforma
Authors: Barros Glhevysson dos Santos , Santos Gláucia Regina da Silva , Siqueira Maria Aparecida dos Santos
Published: April 2022

O referido trabalho apresenta resultados de uma pesquisa sobre a plataforma Educopédia, tendo como participantes professores de educação física da rede Municipal de Educação do Rio de Janeiro. O objetivo do estudo é relatar como esses professores conheceram e aprenderam utilizar a plataforma, além de apresentar a avaliação desses profissionais com relação aos cursos para utilização dessa nova ferramenta e o que acham da interface, da metodologia, entre outros. Trata-se de uma pesquisa qualitativa, privilegia-se assim análise de documentos concebidos pelos colaboradores por meio de entrevistas, para subsidiar nossas análises a partir das narrativas expressadas pelos os mesmos.  Este estudo conclui que a Educopédia representa uma possibilidade viável de se implementar e garantir uma educação de qualidade que esteja de acordo com as expectativas trazidas pelo aluno contemporâneo ao espaço educacional, permitindo uma participação ativa do aluno e apontando para uma dinâmica interdisciplinar, acionando diferentes saberes.
Proposta de criação de aplicativo para contribuir com a melhoria na gestão de resíduos sólidos urbanos
Authors: Araújo de Sousa Monique , Callegario Pereira Ana Carolina , Fourquet Bandeira Cirlene , Andrade de Araújo Joice , Montoro Sérgio Roberto
Published: April 2022

Grandes quantidades de resíduos sólidos urbanos são geradas no Brasil a cada ano e esses números têm crescido ao longo do tempo. Além disso, houve um aumento da quantidade desses resíduos encaminhados a destinações inadequadas. Tal cenário torna necessário o investimento em iniciativas direcionadas a gestão de resíduos sólidos. Por meio de uma revisão bibliográfica de abordagem qualitativa, o presente trabalho busca caracterizar a gestão dos resíduos sólidos urbanos do Brasil, com foco na destinação final. Este trabalho propõe-se a desenvolver um roteiro para criação de aplicativo móvel para a localização de postos de descarte de resíduos sólidos urbanos, visando auxiliar na gestão e conscientização da população sobre a necessidade de haver uma destinação adequada dos resíduos.
Erken Çocukluk Dönemindeki Çocukların Dijital Oyun Oynama Alışkanlıklarına İlişkin Öğretmen Görüşleri
Authors: YİĞİT Nilüfer , MERCAN UZUN Elif
Published: April 2022

Günümüzde çocuklar artık oyun oynamayı ekran karşısında dijital oyun oynayarak vakit geçirmek olarak algılamaktadır. Dijital oyunların çocuklar üzerindeki etkileri okul hayatlarına yansımaktadır. Araştırmada erken çocukluk dönemi çocukların dijital oyun oynama alışkanlıklarına ilişkin öğretmen görüşlerinin ortaya çıkarılması hedeflenmiştir. Araştırma 2020-2021 eğitim öğretim yılı içerisinde Karadeniz bölgesinde bulunan büyükşehirlerden birinde görev yapan okul öncesi ve ilköğretim birinci sınıf öğretmenleri ile yapılmıştır. Çalışmada amaçlı örnekleme yöntemlerinden maksimum çeşitlilik örnekleme yöntemi kullanılarak toplamda 15 öğretmen ile görüşme yapılmıştır. Veri toplamak için demografik bilgi formu ve yarı yapılandırılmış görüşme formu kullanılmıştır. Araştırma sonuçlarına göre öğretmenlerin tamamı sınıflarındaki çocukların dijital oyun oynadıklarını ve dijital oyunların sınıf içerisinde çocukların davranışlarına yansıdığını belirtmişlerdir. Ayrıca öğretmenler ebeveynlerin dijital oyunlar konusunda gerekli sorumlulukları almadıklarını belirtmişlerdir. Ebeveynlerin yanı sıra öğretmenlerin dijital oyunlar konusunda güncel bilgileri takip etmeleri onların sorumlulukları haline gelmiş durumdadır.
Deinking paper in a neutral medium, through a treatment with amino acids, in flotation columns
Authors: Pineda J. Gonzalez , García R. Escudero
Published: April 2022

Mixed waste from office paper (MOW) is an excellent source of low-cost, high-quality fiber for the papermaking industry. The limitations in the application of conventional deinking to such paper are related to the negative environmental impacts that chemical substances can cause, which is why deinking in a neutral medium is receiving increasing attention. This study focuses on investigating the effect of the application of the amino acids Aspartate Glutamate and Asparagine, in the deinking of office paper, using a flotation column on a laboratory scale.The methodology involves the sample preparation, a pretreatment, flotation, the manufacture of paper, microscopy analysis, and finally the evaluation of optical properties. Different doses for each of the amino acids and of the mixture of the three were tested, at different conditions of temperature and pH in the pretreatment.The best optical characteristics were obtained when using the mixture of the three amino acids at 0.6% on a dry weight basis of the paper to be deinked, proposed in this study, with 90.8% whiteness. From scanning electron microscopy analysis, no superficial damage to fiber morphology is observed in any of the fiber samples after deinking.
The Value of Characters in Tabob Folklore (the Leatherback Turtle) in Southeast Maluku
Authors: Etalwewa John Mesak , Juanda Juanda , Agussalim Andi
Published: April 2022

This study aims to (1) describe the form of character values in the Tabob folklore, Southeast Maluku district. (2) Describe the function of the Southeast Maluku Tabob folklore. (3) Analyzing the character values of the Southeast Maluku Tabob folklore. The data in this study are, in the form of written or spoken words from the informants. Sources of data in this study are informants, documents of informants, informants or the community who provide information about local fishermen's folklore. Other data sources such as. The data collection techniques are observation, interview, documentation, and literature study. The data analysis technique used is data reduction, data presentation, and drawing conclusions. The results of the study show that the process of revealing intermediate values in the three folk tales of fishermen, by using respondents or fishermen and local communities who understand the three folklores to provide data. This can be seen from some of the respondents or fishermen who are able to provide data related to the three folklores of Southeast Maluku fishermen well and implemented.
The Effect of Compesations on Job Satisfaction among Employees of Media Industry in Tanzania Lessons from Sahara Media Group
Authors: Lyimo Joan John , Tarimo Elias Adolf
Published: April 2022

It is not well known as to what extent compensation and social benefits effects on employee job satisfaction in the media industry in Tanzania. This paper examines the effect of compensations and social benefits on job satisfaction among employees of Sahara media Group in Tanzania. This study employed simple random sampling and purposive sampling technique. The sample of the study was 80 while the data were collected through questionnaire, interview and documentary review. Moreover, the data was analyzed through descriptive analysis, frequency and percentage analysis and inferential statistics analysis. The study found that there is a strong relationship between the influence of basic pay, job allowances and job satisfaction. The study recommended that Sahara Media Group should modify and keep providing compensation and social benefits to its employees so as to ensure job satisfaction among them.
Modelo de toma de decisiones implementado con BI para la gerencia de ventas en una comercializadora de alimentos
Authors: William George Paucar Palomino , Güere Salazar Fiorella Vanessa , López Cuadros Delia , Cruz García Adalberto
Published: April 2022

La presente investigación tuvo como objetivo dar solución a dos situaciones problemáticas. El primero, la ineficiencia como causa de soporte a decisiones para la gerencia de ventas en una comercializadora de alimentos, en lo que respecta a: la demora en la elaboración de informes (reportes), número de informes al día, tiempo de análisis requerido en el desarrollo de la información y gustos de usuarios. Por otro lado, la carencia de una Metodología pertinente que permita desarrollar soluciones eficientes de Inteligencia de Negocios (BI). Las Metodologías existentes se revisó de manera sistemática, como: Metodología de Ralph Kimball, Bill Inmon, Hefesto, El Enfoque Sistémico es usado como integrador de las metodologías revisadas. La Metodología elaborada y validada tiene 7 fases: Modelamiento del Negocio, y Proceso, Sistemas OLTP, Construir DataMart, ETL, Cubos, y desarrollar Dashboards. Así se logró desarrollar e implementar BI para el soporte de decisiones, mejorando considerablemente los valores de cada uno de los indicadores.
PANORAMA DA VARIABILIDADE DE TEMPERATURA E PRECIPITAÇÃO NO PARANÁ/BR
Authors: Neves de Toffolli Talles
Published: April 2022

Evidências de que certos eventos climáticos e meteorológicos extremos, especialmente em relação a temperatura e a precipitação, mudaram quanto à intensidade e frequência nas últimas décadas. Entre  várias  consequências  dessas mudanças, destacam-se as alterações nas variáveis meteorológicas que podem provocar impactos a sociedade. No Paraná, os resultados das variações climáticas associados à temperatura apontam para um padrão de aquecimento generalizado estatisticamente significativo em grande parte do estado, com aumento das temperaturas mínimas. Em relação a precipitação, em geral são observados padrões de maiores quantidades de extremos, com chuvas mais fortes e maiores intervalos de seca. Destaca-se a urgência na gestão preventiva, a fim de possibilitar a capacidade adaptativa de setores como a defesa e proteção civil, a agricultura, a saúde, o planejamento urbano, o gerenciamento de recursos hídricos, entre outros.
Identifying and Assessing Needs of Florida Commercial Beekeepers Using Nominal Group Technique
Authors: Bammer Mary , Benge Matt , Warner Laura A.
Published: April 2022

The importance of honey bees to global agriculture is largely undisputed (Calderone, 2012; Southwick & Southwick, 1992). Simultaneously, commercial beekeeping operations face tremendous industry stressors that have led to increased management requirements and elevated colony losses in Florida and around the United States. in recent decades (Hodges et al., 2001; Kulhanek et al., 2017). The needs of such beekeepers are largely unknown due to a lack of published literature on beekeepers as a whole. Extension professionals and other agricultural educators can create educational programs to address the needs of constituents once they have assessed these gaps between current and desired states. The purpose of this study was to increase understanding of the issues facing commercial honey bee operations to better guide and develop research, instruction, and Extension programs in Florida and beyond. The objectives of this study were to (a) identify the needs of registered commercial beekeepers in Florida, and (b) prioritize registered Florida commercial beekeeper needs. The highest priority need identified by beekeepers in this study was related to controlling the parasitic mite, Varroa, in honey bee colonies. Other priority needs included effective nutritional management as well as control and management of viral infections, bacteria, and Nosema in honey bee colonies.
Development Of Children's Activity Sheets Based On Aceh Cultural Diversity For Early Childhood Education
Authors: Fuadi Noval
Published: April 2022

This development research aims to produce a Children's Activity Sheet based on local cultural diversity, especially Aceh. This type of research is Research and Development (R&D) with the development model used according to Borg and Gall. The instrument used to measure the validity aspect of the Children's Activity Sheet is an assessment questionnaire by material experts, media experts, and linguists. The results showed that the Children's Activity Sheet was suitable to be used as teaching material, this was based on the assessment score obtained through the assessment score from the material expert getting a percentage of 83.33% with appropriate criteria, the assessment score from a linguist getting a percentage of 80% with the criteria feasible, and the assessment score from media experts gets a percentage of 93.18% with appropriate criteria. In the field trial, the percentage of attractiveness of the Children's Activity Sheet got a percentage of 93.75% with proper criteria. Based on the results of expert validation and product testing, the researcher can conclude that the Children's Activity Sheet is very suitable to be used as teaching material.
Profile of Contemporary Criminal Investigator in Film and Television Content
Authors: Đ. Bjelajac Željko , M. Filipović Aleksandar
Published: April 2022

People have been fascinated by detective novels and complicated investigations since the advent of the detective novel as a literary form in the mid-19th century. The progenitors and early popularizers of this genre, such as Edgar Allan Poe and Arthur Conan Doyle, prepared the ground for later authors of this popular genre. In the meantime, from the beginning to the present day, the techniques and methods of criminal investigations have been immeasurably improved. Criminal and detective fiction has followed innovations, so it has always remained relevant and representative in relation to real-life investigative techniques and methods. Significant development of the TV series as a medium and a massive increase in the quality of the recorded program through a significantly more serious approach and involvement of professionals from the film industry, somewhere since the beginning of the XXI century, has led to a change in approach to procedural and criminal TV series. Instead of the previously trendy but unrealistic and pseudo-scientific procedural programs and detectives whose characterization did not correspond to reality, a new wave of crime series has emerged that is significantly more grounded in reality and faithfully shows the methods and modalities of investigative actions and personalities of criminal investigators. We aim to identify common professional and psychological characteristics of subject investigators using media content analysis, narrative analysis, characterization analysis, and other appropriate analytical methods, and to propose a profile of a modern criminal investigator who, very importantly, corresponds with investigators in real life.
Međunarodnopravni aspekti masovnog nadzora i implikacije na privatnost
Authors: S. Domazet Siniša , S. Dinić Slavica
Published: April 2022

Razvoj savremenih informaciono-komunikacionih tehnologija pored mnogobrojnih pozitivnih strana doneo je i izazove za ljudska prava, a posebno pravo na privatnost. U radu je izvršena analiza odnosa između prakse masovnog nadzora i prava na privatnost. Ukazano je na akutni problem zloupotreba prilikom vršenja prakse masovnog nadzora na međunarodnom planu. Izvršena je analiza postojećeg pravnog okvira na međunarodnom planu, kao i prakse evropskih institucija. Istraživanje je pokazalo da međunarodno pravo ne podržava savremenu politiku i praksu masovnog nadzora kojim se naročito služe velike sile. Utvrđeno je da države, posebno velike sile, pribegavaju argumentu da je ugrožena nacionalna bezbednost ili da postoji opasnost od terorizma, kako bi opravdale praksu masovnog nadzora. S obzirom na nepostojanje univerzalne pravne regulative kojom bi se pravo na privatnost zaštitilo od zloupotreba po osnovu prakse masovnog nadzora, rešenje je u zaključenju bilateralnih sporazuma, ili usvajanju neobavezujućih pravnih normi. U istraživanju su korišćeni normativni metod i pravno-logički metodi indukcije i dedukcije.
Ugovorna teorija Žan-Žaka Rusoa
Authors: Božilović Jelena , Nikolajević Aleksandra
Published: April 2022

U radu se daje prikaz teorije društvenog ugovora Žan-Žaka Rusoa u kontekstu vremena njenog nastanka, ali i u relaciji sa prethodnim, modernim kontaktualnim teorijama. Ukazuje se na složenost i isprepletenosti pojmova opšte volje i suverenosti koje Ruso vidi kao osnovu sporazuma kojim se izlazi iz prirodnog stanja i utemeljuje političko telo zasnovano na građanskoj slobodi. Za razliku od svojih prethodnika, Ruso sporazum, kao i republiku, pre posmatra etički nego pravno, pa političku zajednicu vidi kao onu tvorevinu koja se temelji na moralu njenih građana i integriše zahvaljujući građanskoj vrlini. Takva ideja autora je dalje odvela u pravcu razmatranja vaspitanja u duhu građanske religije, koju je video kao moralnu osnovu jedinstvene i nedeljive nacije, u kojoj su svi pojedinačni i partikularni interesi proglašeni neprijateljskim i razgrađujućim elementom društvenog tkiva. Kolektivistički naboj Rusoove teorije uskoro će postati glavni izvor inspiracije jakobincima i revolucionarnoj tiraniji u Francuskoj nakon revolucionarnog prevrata.