bluuebunny/crossref_metadata_2025 huggingface dataset:
Wnt and Notch signaling pathway involved in wound healing by targeting c-Myc and Hes1 separately
Authors: Shi Yan , Shu Bin , Yang Ronghua , Xu Yingbin , Xing Bangrong , Liu Jian , Chen Lei , Qi Shaohai , Liu Xusheng , Wang Peng , Tang Jinming , Xie Julin
Published: June 2015

Introduction

Wnt and Notch signaling pathways are critically involved in relative cell fate decisions within the development of cutaneous tissues. Moreover, several studies identified the above two pathways as having a significant role during wound healing. However, their biological effects during cutaneous tissues repair are unclear.

Methods

We employed a self-controlled model (Sprague–Dawley rats with full-thickness skin wounds) to observe the action and effect of Wnt/β-catenin and Notch signalings in vivo. The quality of wound repair relevant to the gain/loss-of-function Wnt/β-catenin and Notch activation was estimated by hematoxylin-and-eosin and Masson staining. Immunofluorescence analysis and Western blot analysis were used to elucidate the underlying mechanism of the regulation of Wnt and Notch signaling pathways in wound healing. Meanwhile, epidermal stem cells (ESCs) were cultured in keratinocyte serum-free medium with Jaggedl or in DAPT (N-[(3,5-difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethyl) to investigate whether the interruption of Notch signaling contributes to the expression of Wnt/β-catenin signaling.

Results

The results showed that in vivo the gain-of-function Wnt/β-catenin and Notch activation extended the ability to promote wound closure. We further determined that activation or inhibition of Wnt signaling and Notch signaling can affect the proliferation of ESCs, the differentiation and migration of keratinocytes, and follicle regeneration by targeting c-Myc and Hes1, which ultimately lead to enhanced or delayed wound healing. Furthermore, Western blot analysis suggested that the two pathways might interact in vivo and in vitro.

Conclusion

These results suggest that Wnt and Notch signalings play important roles in cutaneous repair by targeting c-Myc and Hes1 separately. What’s more, interaction between the above two pathways might act as a vital role in regulation of wound healing.
The use of nasal packing post rhinoplasty: Does it increase periorbital ecchymosis? A prospective study
Authors: Al Arfaj Ahmed M.
Published: June 2015

Background

Periorbital edema and ecchymosis following rhinoplasty is disturbing for both the patients and their surgeons. The study aim was to determine whether nasal packing after lateral osteotomies in rhinoplasty surgery increases the risk of periorbital ecchymosis post-operatively.

Methods

This was a prospective self-controlled single-blinded study. Seventy four patients who underwent rhinoplasty with bilateral lateral osteotomies by a single surgeon were enrolled in the study. Nasal cavity packing for one side was done while the other side was left unpacked. Periorbital ecchymosis was evaluated by the operating surgeon and a separate surgeon who is unaware of the packing side separately on the first, fourth and seventh day post-operatively. A 4-grade scale was utilized to assess the ecchymosis with grade 4 being the most severe.

Results

Nasal packing was found to significantly increase the severity and duration of periorbital ecchymosis post rhinoplasty. While no difference was observed between the packed and unpacked sides on the first post-operative day, significant difference was noted on the 4th day (mean score 2.36 and 1.15 for the packed and unpacked sides, respectively) and on the 7th day after surgery in favor of the unpacked side (score 1.24 and 0.61 for the packed and unpacked sides, respectively).

Conclusion

We advise against the routine use of nasal packing in rhinoplasty unless necessary as it contributes to worsen the periorbital ecchymosis from lateral osteotomies and thereby increases the patients’ “down time” after surgery.
Completion thyroidectomy: Predicting bilateral disease
Authors: Ibrahim Badr , Forest Véronique-Isabelle , Hier Michael , Mlynarek Alex M. , Caglar Derin , Payne Richard J.
Published: June 2015

Introduction

It is not uncommon for patients with indeterminate thyroid nodules to undergo diagnostic hemithyroidectomy. When the final pathology determines that the nodule is in fact malignant, patients require counseling as to the whether a completion thyroidectomy is necessary.

Objectives

Determine the incidence of well differentiated thyroid cancer (WDTC) in the contralateral thyroid lobe in patients undergoing completion thyroidectomy. Identify features of the malignant tumor in the initial resection that increase the likelihood of malignancy in the contralateral lobe.

Methods

Retrospective chart review of 97 patients who underwent hemithyroidectomy and completion thyroidectomy in a university's teaching hospital network between 2006 and 2012. Pathology reports from both surgeries as well as patient and thyroid nodule characteristics were reviewed.

Results

Of the 97 patients, 47 (48 %) had a malignancy in the contralateral lobe. In the contralateral lobe, 42/47 (89 %) of malignancies were papillary microcarcinomas (PMC) and 15/42 (36 %) of the PMC were multifocal. Multifocal malignancies in the initial specimen had a 60 % rate of contralateral malignancy and were found to be a predictor of bilateral disease ( p = 0.04) with OR = 2.74 (95 % CI: 1.11–6.79; p = 0.003) in WDTC and OR = 3.59 (95 % CI:1.35 9.48; p = 0.01) in papillary cancer specifically. There was no statistical significant correlation established for the following variables: presence of positive cervical nodes, extrathyroidal extension, positive resection margins, size and angio-lymphatic invasion. Moreover, there was no statistical correlation between any of the variants of papillary thyroid cancer and bilateral disease, even though most aggressive subtypes were found to be bilateral.

Conclusion

In this study, the rate of malignancy in the contralateral lobe was 48 %. Multifocality and presence of an aggressive subtype of papillary thyroid cancer in the initial specimen were found to be more important variables to consider in decision-making regarding completion thyroidectomy than size of the initial tumor alone.
Identification of carbon-based black pigments in four South American polychrome wooden sculptures by Raman microscopy
Authors: Tomasini Eugenia P , Gómez Blanca , Halac Emilia B , Reinoso María , Di Liscia Emiliano J , Siracusano Gabriela , Maier Marta S
Published: June 2015

Introduction

Carbon-based pigments are a group of dark-colored materials, which are classified according to the starting material used and their manufacturing process. Raman spectroscopy is an ideal technique for the identification of carbonaceous matter. Carbon-based pigments show broad bands between 1,300 and 1,600 cm−1 but they differ in position, width and relative intensity, allowing discrimination between them. The aim of the present study was the identification of carbon-based pigments in four polychrome wooden sculptures from the Jesuit Mission La Trinidad in Paraguay.

Results

Analysis of the Raman spectral parameters of the polychrome samples and comparison with those of carbon-based pigment references allowed the identification of wood charcoal, lampblack, bistre and a black earth pigment. Complementary analysis by infrared spectroscopy and elemental analysis supported the assignments.

Conclusions

In this study we have provided new evidence that Raman microscopy is a powerful technique for the discrimination of carbon-based pigments in works of art. This is the first time that bistre, lampblack and a black earth pigment are identified in colonial art. The chemical information obtained on the black pigments contributed to increase our knowledge on available resources and technology used in the manufacture of the polychrome sculptures at the Jesuit Mission. This information is relevant for our studies on Colonial art.
Displacement-Based Probabilistic Seismic Demand Analyses of Earth Slopes in the Near-Fault Region
Authors: Rodriguez-Marek Adrian , Song Jian
Published: June 2015

Near-fault pulses can result in high seismic demands on slopes in the proximity of a fault. A probabilistic methodology to capture the effects of near-fault pulses on seismically-induced slope displacements is proposed. This methodology allows for a separate and more adequate treatment of the sliding displacement of slopes when these are subject to pulse-like near-fault forward directivity motions. Simplified pulse parameters are used to predict displacements for cases where the near-fault pulses may induce resonances in the slope. The method explicitly includes the effects of near-fault pulses both on the ground shaking and nonlinear seismic response of slopes. An example application illustrates the use of the proposed procedure. Results show that the proposed approach increases the predicted earthquake-induced displacements of earth slopes located near the fault. Finally, the proposed procedure generates hazard deaggregation plots that are a useful tool for selecting ground motions for the design of slopes near faults.
Effect of Amine Surface Density on CO2 Adsorption Behaviors of Amine-Functionalized Polystyrene
Authors: Jo Dong Hyun , Lee Chang Hun , Jung Hyunchul , Jeon Sunbin , Kim Sung Hyun
Published: June 2015

Ethylenediamine was grafted onto a polystyrene surface to study the relationship between amine density and amine efficiency. Amine-tethered polystyrene was synthesized in two steps: (1) chloromethylation and (2) amination. The products were characterized by argentometry, N2 physisorption, thermogravimetric analysis, X-ray diffraction, and FT-IR spectroscopy. The amine efficiency declined drastically when the amine density was less than 1 amine molecule per nm2, because formation of ammonium carbamate is difficult under such conditions. A double-functionalization method was introduced to improve the CO2 uptake and amine efficiency of the amine-grafted sorbent by impregnating more amino groups into the porous structure. The combination of grafted and mobile amino groups led to a synergic effect, resulting in a CO2 uptake of up to 20.2 wt % at 30 °C and 1 bar CO2. It was concluded that double-functionalization with tetraethylenepentamine was advantageous for enhancing the amine efficiency, whereas double-functionalization with polyethyleneimine was advantageous for enhancing the cyclic stability of the sorbent.
State regulation of the tourism industry: possible ways od development
Authors: Огнева Светлана , Ogneva Svetlana , Ништ Светлана , Nisht Svetlana
Published: June 2015

The article is devoted to the theory and practice of state regulation in the sphere of tourism. The article considers the concept of state regulation, main tasks, functions, and objectives; the main elements of the system of state regulation. Confirmed are the need to change the forms and methods of state regulation in a market economy while maintaining the significant role of the state. The classification of measures of state regulation is proposed. The authors describe characteristic instruments of state regulation applied in accordance with Russian law, in relation to the tourism industry, the peculiarities of application of measures of state regulation of tourism at the regional level and the possibility of transferring some of them to the federal level, and the fixing of these legislative measures. Such measures may include the creation of material safety of organizations of the tourism industry, the classification by security category. It is proposed to form a national system for the protection of tourists aimed at increasing the responsibility of all executive authorities involved in this process. Special attention is paid to interaction of executive authorities and business on the basis of state-private partnership and regulation, in order to reduce administrative burden on tourism and hotel activities. Proposals are made on the transfer of authority to carry out the classification of the objects of the tourism industry bodies self-regulation of business in order to reduce public costs for the implementation of this activity and accountability of hotel organizations for the quality of services provided. Identified are measures to improve the quality of regulation: assessment of alternative ways of achieving this goal (to overcome the flaw of the market) at the stage of development of the draft of regulatory solutions; procedural restrictions on the adoption of measures required for implementation by business entities; providing public procedures of regulatory decision-making.
SPA-services and their regulatory control
Authors: Зворыкина Татьяна , Zvorykina Tatyana , Сильчева Людмила , Silcheva Lyudmila
Published: June 2015

One of the rapidly developing at the present time segments of the economy in the beauty industry in the regions of the Russian Federation is the spa industry. Most professionals working in the hospitality industry celebrate the new mandatory component in the "portfolio needs" of tourists, which are wellness and spa treatments during the journey. The article focuses on the development of spa services in the Crimea as one of the most important segments of the economy of the beauty business in the region. On January 21, 2015 in Crimea at the business forum "South of Russia 20:15. Time to rest in a new way" there were addressed issues of a competitive SPA product. The forum was attended by representatives of the business community and the Ministry of Resorts and Tourism of the Republic of Crimea. It is noted that the traditional leader of innovative development of spa industry in Russia is the Crimea. This is due to the natural features of the region, its medical resources, as well as the development of technological and technical content of this type of service. There was presented a catalog of spa facilities and spa products at the forum, which is formed by the union ofprofessionah «SPA-professionals Crimea." The article states that an effective instrument to ensure the quality and safety of spa services, as well as the way of fair competition among market participants is standardization. The authors present a conceptual model of one of the fundamental standards in the field of spa services — GOSTR 55317—2012 "Public services. Spa services. Terms and definitions " and assess the feasibility of its application in the territory of Crimea.
The structure of the educational model in tourism: a theoretical basis
Authors: Сахарчук Елена , Sakharchuk Elena
Published: June 2015

Based on the theoretical analysis, the results of which are described in the previous publications of the author on the topic of international comparative educational research [8, 16—26], substantiated is structure of the model of the education system in the tourism sector, which is the unity of four interrelated subsystems: content, functionality, industry regulation and consumer. The model of education in the field of tourism is based on an integrative approach [16] to the analysis of factors of internal and external environment of education, it allows to search the determining changes in factors of the education systems [17, 18], identify patterns, to explain the possibility of borrowing pedagogical models, processes, phenomena, develop mechanisms of adaptation of pedagogical models, processes, phenomena, as well as to design useful pedagogical models of processes and phenomena. The author stresses the necessity of the use of scientific instruments in the research and development of training models that take into account the structural characteristics and process of education. As the properties of the model are determined by integrating the conceptual mainstream; for the purposes of the study of national models of training in the field of tourism as a mainstream concept adopted is the principle of integration of the national professional education in the global professional and educational space. In order to address the structural and process characteristics of the education systems the author proposes the relationships between the subsystems of the education system (functional, consumer, industry regulation and content) as the features of the system and the principles of the educational system as a social institution that ensures the reproduction and development of human potential as attributes of the system. In the article the subject of pedagogical analysis of educational systems is determined by the purpose and nature of the education system in the field of tourism as a sustainable set of integrated or integrating interacting elements which are subsystems. Developed is a heuristic model of education in the field of tourism which not only can help to carry out a comprehensive analysis of teaching, but also to compare national systems of vocational training, and by identifying their features, focus the mind on its own problems and bottlenecks and find points of growth of the potential and to develop mechanisms of adaptation of useful foreign experience.
Tourist businesses in the UK: history and main directions of the development of the industry
Authors: Логинова Наталия , Loginova Nataliya
Published: June 2015

The article presents an overview of the tourist potential of the UK, including the history of development of tourism in the country, the main areas of inbound and outbound tourism, the structure of public sector management, as well as development prospects. Particular attention is paid to the statistics of inbound and outbound tourism of the UK in recent years; described in detail are the most popular tourist routes, including not only historical and cultural sites, but also the basic directions of business, sports and music tourism. Using domestic and foreign sources (books, periodicals, electronic resources), the author gives a detailed description of the tourist business in the UK as one of the largest sectors of the economy, but also notes that the historical facts and recent data indicate significant prospects for further sustainable development of tourist interest to the UK, its cultural heritage and modern achievements in science, industry, business. It is likely that the forms of organization of tourism in the United Kingdom will change and improve, but the flow of tourists to the UK will not dry up, including from Russia. At the heart of it will remain the dominant business, educational and cognitive forms of tourism.
Managing a sanatorium and resort enterprise in the market economy
Authors: Прохорова Ольга , Prokhorova Olga , Краснова Ольга , Krasnova Olga
Published: June 2015

The aim of the article is to determine the characteristics of management of spa facilities. The urgency of this problem stems from the fact that over the past quarter-century historical period of market relations the potential of the spa treatment, rehabilitation and recreation in Russia decreased in four times. To a certain extent this is due to the lack of entrepreneurial activities. It is proved that every enterprise of the sanatorium sphere should operate two separate, but organically interrelated management tools: a) the mechanism for managing the treatment, which is impossible without the second tool; b) a mechanism for business, creating conditions for effective treatment and rest. We consider that the results of spa businesses are two products: the first - in the form of creating conditions for rest and treatment. This product is sold in the form of vouchers, the value of which compensates for the cost of the enterprise to carry out treatment, and creating conditions for rest and allow a profit. Consumers of spa services as a result of rehabilitation and treatment restore and are involved in the manufacture of a product of society, therefore, the result of the treatment can be expressed in the form of a certain percentage of growth of the human capital of the country. Features of the mechanism of entrepreneurship in the health resort company is not the product (as a set of conditions for treatment and rest, and the system of health services) delivered to the consumer, but on the contrary, consumer services to the product. Presented are tree goals of the process of creating these two products by sanatorium enterprises. From the facilities management of spa businesses highlighted is its foundation mechanism - organizational and economic. It is a set of organizational structures, concrete forms and methods of management tools and instruments, as well as the organic unity of production, financial, social, technological and economic relations, legal forms, affecting business entities of sanatorium branch in order to create conditions for qualified rehabilitation of recreants with continuous improvement of medical base, hotel services and providing a comfortable stay for guests.
Disability as a predictor of special needs for tourist services
Authors: Сигида Евгений , Sigida YEvgyeniy , Баклагина Наталья , Baklagina Natalya , Лукьянова Инна , Lukyanova Inna , Киреенкова Зоя , Kireenkova Zoya
Published: June 2015

In modern society, tourism is of great socio-cultural importance of forming new behavior algorithms of various categories of the population. The flow of tourists increases, more people appear with disabilities who remain limited mobility due to the presence of numerous social barriers that need to be adaptive conditions of consumption of tourist services in the framework of tourism, accessible to all. Involvement of disabled people in the tourism industry remains an unsolved problem. Persons with special needs in tourist services are among the switched off from society. Issues related to the provision of tourist services are resolved not to the full extent without the conditions for such activities. Information about opportunities for persons with disabilities in Russian is very limited. Use of tourism in the system of social protection remains the least affordable and little studied. At the same time, tourists with special needs in the travel services are potential customers for businesses, they can participate in the economic development, to make a profit. We believe that to a certain degree this is connected with insufficient development of theoretical and conceptual issues of adaptive tourism, which affects in particular the question of society´s attitude to such concepts as "human health" and "disability". Considering tourism as a complex adaptive relationship, social, psychological, medical, sports and recreation and other measures which are included in the content of tourism activities in providing tourism services for persons with special needs, the priority is allocated in a specific form of psychosocial work at all levels of the tourism industry. Adaptive tourism is focused on the study and implementation of subject-subject relationship that accompany the promotion tour. And it´s not only the elimination of barriers to the movement of the mechanical traveling. The question is about a particular way of working with people with special needs in tourist services. lack of attention to categories of people requiring special conditions in tourism, underdevelopment of appropriate infrastructure reduce the motivation for learning by those who in their professional activities would like to have specific tourist services to persons with disabilities. Adaptive tourism is based, on the one hand, on the general theory and methodology of social work, and on the other- on the technology of the organization of tourist activity and the concept of adaptive physical training (adaptive physical education, adaptive sports, adaptive motor recreation). Our research has allowed developing the scientific and theoretical basis of the concept of model-specific tourism activities and offers a training profile for psychosocial workers capable of organizational and managerial activities with persons with special needs in tourist services.
The economic crisis as incentive to the development of the recreational and tourist complex in Northern Moscow Region
Authors: Хетагурова Валерия , Khetagurova Valeriya , Голубчиков Сергей , Golubchikov Sergey , Брюханова Галина , Bryukhanova Galina
Published: June 2015

The article examines the development of domestic tourism as an example of recreational and tourist complex in the Northern suburbs of the Moscow region. High tourist and recreational potential of the Russian Federation and its subjects is far from being fully utilized. This requires the combined efforts of all agencies involved in the tourism sector and create conditions for the effective development of tourist-recreational and spa complex in Russia, including in Moscow. The methodology of research is relatively laid-analytical, historical and geographical methods, which include the analysis of the basic regulations for tourism development at the federal and regional levels, the elaboration of plans and strategies for socio-economic development of cities and districts of the Moscow region, stock and literary materials, sociological surveys of population and decision-makers. The article made a brief analysis of objects of historical, cultural and recreational tourism in the region. Recreational resources are extremely rich in Moscow suburbs and include hundreds of travel sites. The Moscow region has a very high concentration of historical and cultural monuments. Despite some rise of tourism activities in the Moscow region in recent years, so far, the industry has not qualified for the high level of the budget of the region, which is observed in the metropolitan suburbs of developed countries. The article presents guidelines for creating the tourist and recreational zone cluster «Northern Moscow suburbs» that would specialize in cultural, educational, event-related, scientific, educational, ecological and local tourism, business, pilgrimage, sports, ski tourism and the development of leisure. For the development of tourism in the Northern Moscow suburbs, recommended are the following activities: design and development of the recreation and tourism zone cluster; development and implementation of regional programs and strategies for tourism development at the municipal level; assessment and inventory of recreation and tourism, educational and cognitive potentials of the region; Established are effective mechanisms for the conversion of recreational and tourism resources in the tourism product; development of rural types of tourism; tourism industry transition to an innovative, community-oriented and spatially balanced pattern of economic development; the development of cruise tourism on the channel of the Moscow and Volga rivers.
Routes of active tourism as a means of education in historical memory for the youth (on the example of the bicycle tour «Mouranovo–Abramtsevo»)
Authors: Лагусев Юрий , Lagusev Yuriy , Потапенко Татьяна , Potapenko Tatyana
Published: June 2015

Tourism has a significant educational function. Therefore, the inclusion of potential historical and cultural heritage routes into active tourism and educational activities is a priority objective of educational planning of tourist-excursion work with the youth. Thus, it is possible to talk about the ideological platform of educational activities in tourism.

The territory of Moscow region has a considerable potential for development and expansion of the route network of active tourism. Important points of tourist attraction are, in particular, on the territory of Klinskiy and Volokolamskiy municipal districts. On the basis of the field of tourism research carried out jointly by employees of RSUTS and State Tyutchev Memorial estate «Mouranovo» Intermunicipal developed military-historical cycle route «Muranovo - Abram-tzevo» is suggested.

The cycling tourist route developed and described in the article includes visits to a number of objects related to the events of different eras in the history of the Russian state, in particular: Museum-Estate «Muranovo», villages Danilovo and Artyomovo, villages Kalistovo and Vasilevo, town Akadimikov, estate of Trubetskoys in Akhtyrka, Museum «Abramt-sevo». The program also provides a route to familiarize with the history of local history work in the municipalities of Sofrino and Sergievskiy regions, natural features of Sergievskiy region, unfolding events in the region during the Great Patriotic War

It is important that in the preparation of active tourism activities are fully implemented is a moral educational tourism phenomenon, and effective distinctive content is emphasized. The proposed tourist cycle route is a vital social event, forming the historical memory of the younger generation and contributing to the education of the youth.
Modern life of the museum. Programmes and festivals in the Memorial Estate «Mouranovo»
Authors: Шапарина Евгения , Shaparina Evgeniya
Published: June 2015

Last ten years there were lots of things which appeared in wide museum activity connected with its visitors. Museums, not leaving the traditional excursion routes, tried to use the most different ways to improve their programs with experience of teachers, psychologists, actors and animators. How can we manage work in an average museum today in changing economic circumstances? How can we create and offer a museum product which is so necessary and demanding? What do our visitors expect to have in a museum area?

According to analysis the last programs made by the Mouranovo museum creative group of staff (they tried to form a vivid atmosphere in museum exposition to improve the number of visitors) it is obvious what we have to do for the new museum position. The article is dedicated to the way how to translate the main idea of the museum experience and show the museum´s treasures. Museum staff has to find like-minded partners who can be involved in museum ethic as well as in cultural and historical things of the place, to put in everyday museum life some new and interesting programs. We have already have some museum programs and festivals very popular for our visitors as «the Haymaking in Mouranovo», «the Maslinica in Mouranovo», «the Jam Day», «the Winter festivals», «the Saturday Croquet», theatrical excursion «the country estate kitchen» etc. Theatrical forms for representing the museum subjects make perception lighter and put it in emotional way. The result of the work is the last «Maslenica in Mouranovo» (2015). 5500 people visited and took part in the fest during twodays. So at the moment museum management and development is one of the most important tasks for we must receive lots of visitors in a proper way and give them a full-fledged rest.
«A corner of paradise near Moscow …» Estates «Boblovo», «Shakhmatovo», «Tarakanovo» in Solnechnogorskiy and Klinskiy districts
Authors: Мойко Ольга , Moyko Olga , Чехомов Валерий , Chekhomov Valeriy , Емельянова Ирина , Emelyanova Irina
Published: June 2015

The article is devoted to the professional activities of woman family members of the Beketovs and their contribution to the Russian culture and education. The family owned the estate in the suburbs «Shakhmatovo», which is considered to be the spiritual home of Alexander Blok. It>s a cultural thing, «nest» from which, in the figurative expression ofS. Solovyov (second cousin of the poet), «the swan flew the new Russian poetry». The article describes the legacy left by the descendants of Elizabeth, Ekaterina, Maria Beketovs, Sofya and Alexandra Kublitskaya-Piottukh´s. This article contains information about the epistolary heritage of the family of Alexander Blok and the Beketovs with outstanding Russian scientists and writers.

From the estate of Captain Tarakanov are related important events in the life of Alexander Blok. Here, in the church of the Archangel Michael held his wedding with Lyubov Mendeleeva as reflected in the work of the poet. The article lists the artifacts stored in the estate and nearby museum institutions associated with this outstanding family.
On the birth of theatrical tradition in the estate of D. I. Mendeleev «Boblovo»
Authors: Смирнов Николай , Smirnov Nikolay
Published: June 2015

The present paper is the result of years of hard work of the author on the study traditions of family life of the great Russian scientist D. I. Mendeleev, his close and distant relatives. It is dedicated to the 150"1 anniversary of the purchase by D. I. Mendeleev in June 1865 of Boblovo, which is a resurgent Northern Moscow Region estate.

In the circle of the descendants of the great scientist often talk about the «Clan ofD. I. Mendeleev». It included members of the first and second families of D. Mendeleev: Theosebia Nikitichna first wife, his second wife, Anna Ivanovna, and their children, six in two marriages of Mendeleev. Readers iare offered to learn about Mendeleev who led a unique family, which included brothers and sisters, nephews, great-nephews of the scientist, his friends.

One of the traditions of Mendeleev>s clan was known as barn-theater productions with active participation of the poet Alexander Blok. Of course, the poet can be safely attributed to the «Clan of Mendeleev». This rather large community of citizens of modern Russia includes the author of the article, who belongs to the generation of great-great nephews ofD. I. Mendeleev.

Author´s research methodology is original, it is dominated by information received from the mouth of the descendants of the great scientist. The article mentions a totally unique document that sheds light on the many pages of the history of Boblovo. This document adds new content road tour «Bol´shoe Shakhmatovo» linking Shakhmatovo (A. A. Blok estate) with the estate ofD. I. Mendeleev and villages Pokrovskoe, Rogachevo, Ivanovo, St. Nicholas-Peshnoshsky monastery, estate «Tarakanovo».
A record reading summer
Authors: Hampshire Viv
Published: June 2015

The summer can be wonderful for young children, freed as they are from the rigours of school life, but childminders will want to make sure that basic skills are not forgotten.
A randomised study of NPWT closure versus alginate dressings in peri-vascular groin infections: quality of life, pain and cost
Authors: Monsen C. , Acosta S. , Mani K. , Wann-Hansson C.
Published: June 2015

Objective:

The aim of this study was to compare the vacuum assisted wound closure (VAC) system (negative pressure wound therapy; NPWT) and alginate wound dressings in terms of quality of life (QoL), pain resource use and cost in patients with deep peri-vascular groin infection after vascular surgery.

Method:

Patients with deep peri-vascular groin infection (Szilagyi grade III) were included and randomised to NPWT or alginate therapy. EuroQol 5D (EQ-5D) and brief pain inventory (BPI) were used to evaluate QoL and pain, respectively.

Results:

Wound healing time until complete skin epithelialisation was shorter in the NPWT (n=9) compared to the alginate group (n=7), median 57 and 104 days, respectively (p=0.026). No difference was recorded in QoL and pain between the groups at study start and the second assessment. QoL analysis within groups between time points, showed that patients in NPWT groups improved in EQ-5D domains, ‘self-care’ (p= 0.034), ‘usual activities’ (p=0.046); EQ-5D index value (p=0.046) and EQ-VAS (p=0.028). Patients in the NPWT group reported significantly less pain ‘affecting their relations with other people’ and ‘sleep’ between time points. The NPWT group had significantly fewer dressing changes compared to the alginate group (p<0.001). The median frequency of wound dressing changes outside hospital was 20 (IQR 6–29) in the NPWT group (n=9), compared to 48 (IQR 42–77) in the alginate group (n=8; p=0.004). The saved personnel time for wound care in the first week for the NPWT group, compared with the alginate group, was 4.5 hours per week per nurse. The total hospitalised care cost was 83–87% of the total cost in both groups.

Conclusion:

NPWT therapy in patients with deep peri-vascular groin infection can be regarded as the dominant strategy due to improved clinical outcome with equal cost and quality of life measures.
Outcomes for split-thickness skin transplantation in high-risk patients using octenidine
Authors: Matiasek J. , Djedovic G. , Unger L. , Beck H. , Mattesich M. , Pierer G. , Koller R. , Rieger U.M.
Published: June 2015

Skin transplantation is a commonly used surgical technique; however, the complication rate, including postoperative infection and delayed wound healing due to inefficient perfusion, is significantly higher in patients suffering from comorbidities. Hence, a subsequent repeat procedure is often necessary. In this report, two case studies are presented in which an octenidine-based antiseptic is used with a tie-over dressing (TOD) instead of povidone iodine (PVP-iodine), following a split-thickness skin graft. The two patients selected were deemed to be at high risk of impaired wound healing due to comorbidities.

The first patient, a confirmed smoker with diabetes, presented with a nodular melanoma that was resected and covered with a split-thickness skin graft. After 5 days of negative pressure wound therapy as a TOD, in combination with PVP-iodine, the graft became necrotic. A second split-thickness skin graft was performed and an antiseptic regimen with octenidine in combination with the same TOD resulted in a completely healed transplant.

The second patient, also a confirmed smoker with diabetes and receiving oral corticosteroid treatment, was diagnosed with a skin necrosis on her leg. Following the split-thickness skin graft, octenidine and TOD were applied. The patient's skin graft completely healed without any adverse events.

These two case studies indicate that the combination of octenidine and TOD following split-thickness skin transplantation is safe, well-tolerated and appears to have positive benefits in the reconstruction of defects in patients with impaired wound healing.
Are you ready for sports day?
Authors: Pope Marianne
Published: June 2015

When preparing for sports day, there are eight key aspects that schools must consider. Marianne Pope explains
Organising a summer school
Authors: Rippon Les
Published: June 2015

Summer schools can help to ease the anxiety of transition for year 6 pupils. Headteacher Les Rippon advises on how to prepare and run an effective summer school
Evaluación y comparación de métodos de interpolación determinísticos y probabilísticos para la generación de modelos digitales de elevación
Authors: Paredes Hernández Cutberto Uriel , Salinas Castillo Wilver Enrique , Martínez Becerra Xicoténcatl , Jiménez Hernández Sergio Bernardo
Published: June 2015

Los modelos digitales de elevación (MDE) son la forma más común y eficaz de representar la superficie terrestre. Desafortunadamente, al igual que la mayoría de la información geográfica en formato digital, los MDE contienen errores de forma inherente, por lo que es necesario evaluar la magnitud de dichos errores e informar de su existencia a los usuarios de MDE. Uno de los factores que introduce errores en los MDE es el método de interpolación y diferentes estudios previos han presentado conclusiones que discrepan entre sí en cuanto a la idoneidad de diferentes métodos de interpolación para la generación de MDE. Con el objetivo de contribuir a dicha discusión y de mejorar el entendimiento del error introducido por métodos de interpolación en los MDE, en este trabajo se evalúa y compara la precision de MDE generados utilizando métodos de interpolación determinísticos (IDW, ANUDEM) y probabilísticos (OK, KT). Nuestros resultados sugieren que KT genera MDE más precisos que el resto de los métodos de interpolación aquí evaluados y sin la presencia de errores sistemáticos, como ocurre en los MDE generados usando IDW, ANUDEM y OK. Dichos resultados concuerdan con algunos estudios previos, pero discrepan al mismo tiempo con otros estudios similares.
Criterios geológico-hidrológicos para recomendaciones del uso de suelo en zonas conurbadas sujetas a afectaciones por lluvias intensas. Caso de estudio: sur de la ciudad de Tuxtla Gutiérrez, Chiapas
Authors: Espíritu Tlatempa Gloria
Published: June 2015

Actualmente en la zona conurbana sur de la ciudad de Tuxtla Gutiérrez se manifiestan movimientos geológicos en donde la urbanización promueve su propia vulnerabilidad principalmente ante lluvias intensas provocadas por fenómenos hidrometeorológicos como tormentas tropicales y huracanes, e incluso de lluvias ordinarias, impactando además a otras partes bajas de la ciudad. Este trabajo determina zonas potencialmente activas e inactivas y su vulnerabilidad física en cuatro cuencas a escala 1:20 000, lo que permite integrar criterios que identifican localmente a los procesos evolutivos de movimientos de masas en laderas, determinando escenarios temporales de actividad peligrosa. Para la obtención de elementos categóricos, los resultados muestran los peligros diferenciados en geológicos y los que tendrán su máximo desarrollo en lluvias extraordinarias; de los cuales se deriva a la determinación de sitios para la conservación, rehabilitación y con menor restricción de uso urbano.
Manutenção centrada em confiabilidade (MCC): análise quantitativa de um forno elétrico a indução
Authors: Cerveira Diego Santos , Sellitto Miguel Afonso
Published: June 2015

O objetivo deste artigo é definir uma estratégia de manutenção para um forno elétrico a indução, instalado em uma fundição de aços especiais. O método de pesquisa foi a modelagem quantitativa. O método proposto é baseado na metodologia da Manutenção Centrada na Confiabilidade (MCC), aplicada a equipamento industrial. Análises quantitativas de confiabilidade, mantenabilidade e disponibilidade foram usadas como ferramentas de apoio à definição da estratégia de manutenção do equipamento. Para a pesquisa, foram coletados dados históricos de tempo até o reparo (TTR) e tempo entre falhas (TBF) do equipamento em estudo. Com o auxílio do software ProConf 2000, foram identificadas e modeladas as distribuições mais adequadas para esses tempos: lognormal (TTR) e Weibull (TBF). Com os valores obtidos foi possível calcular a disponibilidade do equipamento, Av = 98,18%, e o fator de forma g = 1 da distribuição de Weibull. Foi possível posicionar o equipamento na curva da banheira, na fase de maturidade e definir a melhor estratégia de manutenção para este caso, a preditiva. Por fim, discutiu-se a estratégia adotada atualmente pela empresa e apresentaram-se sugestões de desenvolvimento para esta estratégia.
Correlações entre qualidade de vida no trabalho e comprometimento organizacional: estudo em uma unidade de varejo de vestuário na cidade de Joinville/SC
Authors: Zanardi Eduardo , Pilatti Luiz Alberto , Santos Celso Bilynkievycz dos , Godoi Heloisa , Claumann Patricia Del Castanhel
Published: June 2015

O trabalho em questão tem o intuito de contribuir para com o tema Qualidade de Vida no Trabalho (QVT), analisando as possíveis relações entre QVT e Comprometimento Organizacional (CO) através de aplicação de questionários estruturados. Para tal, utilizou-se uma amostra de 40 colaboradores de uma loja de departamentos de uma rede nacional de varejo de moda localizada no município de Joinville/SC. Para efetuar o estudo, utilizou-se o coeficiente de Pearson para demonstrar a relação entre os fatores. Os resultados indicaram uma relação moderada positiva entre a QVT e CO na faceta “Permanência” do colaborador na organização. Concluiu-se que melhorando a percepção positiva da QVT por parte dos colaboradores, possivelmente pode-se esperar menor rotatividade de pessoas.
Planejamento, condução e análise do método de avaliação de uma disciplina do curso de engenharia de produção fundamentada na aprendizagem baseada em problemas
Authors: Pinto Camila Pereira , Scheidegger Anna Paula Galvão , Gaudêncio Juliana Helena Daroz , Turrioni João Batista
Published: June 2015

Em um mercado altamente competitivo, as empresas necessitam de recursos humanos cada vez mais qualificados, em especial no que se refere à Engenharia. As Universidades desempenham, pois, um papel importante, ao formar os futuros profissionais do país.  No entanto, nesta tarefa, as Instituições deparam-se com o desafio de atrair e trabalhar com jovens da Geração Y, que apresentam anseios não mais atendidos apenas pelos métodos tradicionais de ensino. A Aprendizagem Baseada em Problemas (ABP) é uma abordagem que visa estudar e desenvolver alternativas de ensino que atendam às exigências das empresas, bem como o novo perfil de estudantes. Além disso, ensinar ativamente por si só não é uma tarefa simples e torna-se mais complexa quando é preciso avaliar o conhecimento adquirido através desse método. Deste modo, este trabalho busca apresentar o planejamento, a condução e o método de avaliação adotado em uma disciplina de Engenharia de Produção na Universidade Federal de Itajubá fundamentada na ABP. Para isso, adotou-se o método de pesquisa-ação, onde os autores participaram ativamente das etapas da disciplina, atuando como facilitadores no planejamento, implementação e monitoramento desta e do método de avaliação adotado. Como resultados, destacam-se os benefícios alcançados pelos envolvidos através do ensino ativo, bem como os pontos fortes e fracos do método. Além disso, propõem-se melhorias para futuras disciplinas.
事例研究特集号¯はじめに 日本における事例研究:2つの方法,2つの世界観
Authors: 岩壁　茂 Iwakabe
Published: June 2015

PCSPの本特集号では日本における2つの事例研究を紹介し,続いて次々号では,異なる研究の背景を代表する4人の著名な心理学者のコメント,そのコメントに対する事例研究論文の執筆者の回答を紹介する。日本の臨床心理学はその歴史を通して心理療法における事例研究の中心的な役割と,実践・研究・訓練と事例研究の不可分性を強調してきた。臨床心理学の学術誌には数多くの事例研究が掲載され,そのため,多くの臨床家は専門家としての成長に資する活動として事例研究に携わっている。しかし,このように事例研究が臨床心理学の中心に据えられているにもかかわらず,その方法論的問題についての検討には結びついていない。何が良い事例研究を構成するのか,あるいはどんな種類のエビデンスや根拠が事例研究における妥当な推論のために必要なのかということはほとんどふれられてこなかった。日本の心理学における多種多様の事例研究は,一方に伝統的なナラティブ形式の臨床事例研究があり,もう一方にターゲットとされる症状の変化を客観的にモニターする科学的に厳密な一事例実験デザインがあり,その二極のあいだに位置づけられる。本特集号で,この二極の事例研究の形態の際立った例をそれぞれ提示する。本特集号に紹介する2つの事例研究は,系統的で厳密な事例研究が心理療法研究の一形態としてどのように行われ,報告されるのかということについての異なるモデルを表す。本特集では,(a)これらの方法論的な基準を満たすより多くの事例研究を奨励するため,(b)異なる事例研究の方法論についての議論を活気づけるために,これらの2つのモデルを合わせて提示する。
描画を通したコミュニケーション: 人間不信を標榜しながらも, 他者とのつながりを希求する青年R氏の事例
Authors: 村瀬　嘉代子 Murase
Published: June 2015

本事例研究は,介入開始時に18歳だったR氏との心理療法プロセスを報告する。6ヶ月のあいだに全10回の面接を実施した。当時,筆者は,臨床家としてまだ経験も浅く,一方では人を人として遇する態度,そしてもう一方では現実生活の場への適応を大切にする統合アプローチを思惟する最中であった。来談当初,R氏は,家庭内暴力がひどかった。異なる精神科医から,パーソナリティ障害,統合失調性情動障害,非定型の精神病等の診断がつけられていた。それまでの話すことを介した通常の心理療法も薬物療法も成果が上がらなかったため,筆者は,人を人として遇し,素直さと真剣さに特徴づけられる関係を作れるよう心がけ,感情を表すため一方法として描画を用いた。R氏が描いた一連の作品を本論文に提示した。これらには,歴史的人物が次々に描かれるが,その変移が治療的変化と並行している。心理療法を通して,R氏の攻撃性は和らぎ,筆者に対しても敵意ではなく,つながりと尊重を求める欲求からかかわるようになっていった。終結後40年近い年月が流れたあと,R氏のご家族が,別人のように落ち着きを取り戻し,平穏に暮らしていることを報告してくださった。筆者は,本事例のいくらか特異な臨床的判断についての根拠を(a)当時の日本における心理療法実践の文脈,(b)それまでのすべての治療を中断したR氏が当時求めていたこと,(c)R氏および彼のご家族と関連する他の要因との関連から述べる。
Application of aluminosilicates for mitigation of ammonia and volatile organic compound emissions from poultry manure
Authors: Opaliński Sebastian , Korczyński Mariusz , Szołtysik Marek , Dobrzański Zbigniew , Kołacz Roman
Published: June 2015

Odor mitigation techniques are widely investigated due to the problem of odor nuisance generated by intensive livestock production. The goal of this research was to investigate the use of aluminosilicate sorbents as filter packs in the air scrubber ODOR1, which enables cleaning of air inside the livestock building. The following sorbents were examined: raw halloysite, roasted halloysite, activated halloysite, raw bentonite, roasted bentonite and expanded vermiculite. The experiment was conducted in chambers where poultry manure was placed, the time of air treatment was 24 hours. A manual SPME (solid-phase microextraction) holder with DVB/Carboxen/PDMS fiber was used for extraction of odor compounds, and analyses were carried out using gas chromatography-mass spectrometry. Ammonia concentrations were determined according to Polish standards (Nessler method) using a spectrophotometer. It was found that all examined aluminosilicates had the potential for removal of ammonia as well as 24 volatile compounds emitted from poultry manure. The highest efficiency was noted for activated halloysite (81%) and roasted bentonite (84%) in the case of ammonia and odors, respectively. Despite the limitations of the study, the results showed the effectiveness of the air scrubber packed with aluminosilicates for the reduction of volatile odorous compounds in the air of livestock buildings.
Climate Change Adaptation Will Offer a Sharp Test of the Claims of Behavioral Economics
Authors: Kahn Matthew E.
Published: June 2015

Concepts from behavioral economics can be used to make predictions concerning how climate change will impact the economy. Six new predictions from behavioral economics are compared to their rational expectations counterparts.