bluuebunny/crossref_metadata_2025 huggingface dataset:
A Balance of Unimolecular and Bimolecular Pathways Control the Temperature-Dependent Kinetics of Ozonolysis in Aerosols
Authors: Reynolds Ryan , Wilson Kevin
Published: October 2024

To better understand the key kinetic mechanisms controlling heterogeneous oxidation in organic aerosols, submicron particles composed of an alkene and a saturated carboxylic acid are exposed to ozone in a variable-temperature flow tube reactor. Effective uptake coefficients (γ_eff) are obtained from the multiphase reaction kinetics, which are quantified by Vacuum Ultraviolet Photoionization Aerosol Mass Spectrometry. For aerosols composed of only of alkenes, γ_eff doubles (from 6x10-4 to 1.2x10-3) when the temperature is decreased from 293 to 263 K. Alternatively, for an alkene particle doped with a carboxylic acid, an efficient scavenger of stabilized Criegee Intermediates (sCI), γ_eff is observed to be weakly temperature dependent. A kinetic model, benchmarked to literature data, explains these results as arising from the temperature dependent competition between unimolecular pathways of sCI that promote radical chain cycling and those bimolecular pathways that form stable chain termination products (i.e., ɑ-acyloxyalkyl hydroperoxides). The implication of these results for the kinetics of aerosol aging at low temperatures is discussed.
Rationally Grafting A Synthetic Multinuclear Metal Center into a Cytokine: A Dual-Functional Designer Metalloenzyme
Authors: Ueno Akiko , Takida Fumiko , Kita Tomoki , Ishii Takuro , Himiyama Tomoki , Mabuchi Takuya , Okamoto Yasunori
Published: October 2024

A designer enzyme consisting of an abiological molecule incorporated into a natural protein has been developed as an exceptionally chemoselective catalyst, highlighting that the internal space of proteins is highly beneficial for enhancing catalytic performance. However, other superior features of proteins have received less attention in designer enzymes: e.g., their use as ligands to construct abiological (multinuclear) metal centers and an intrinsic protein function that has often been traded off for a new function. Here, grafting a synthetic trinuclear zinc complex inside a human cytokine macrophage migration inhibitory factor (MIF) scaffold using solely amino-acid side chains led to a designer multi-metalloenzyme with extrinsic and intrinsic functions. The crystal structure of the designer tri-zinc enzyme verified the high accuracy of our design process based on geometry optimizations and quantum-chemical calculations. The extrinsic catalytic performance of this designer enzyme is of the highest class and comparable to that of previously reported designer zinc hydrolases. Importantly, an intrinsic function of MIF, i.e., its tautomerase activity, was maintained in this designer tri-zinc enzyme. Considering that cytokines are originally expressed in response to in vivo events, this cytokine-based designer metalloenzyme shows promising potential as a synthetic biological tool for the self-adaptive regulation of life phenomena.
Unbiased Dataset for Methane Dry Reforming and Catalyst Design Guidelines Obtained by High-Throughput Experimentation and Machine Learning
Authors: Du Wentao , Chammingkwan Patchanee , Takahashi Keisuke , Taniike Toshiaki
Published: October 2024

Traditional solid catalyst design is a highly labor-intensive and post hoc process, involving repeated experimental trials and errors based on hypotheses derived from prior knowledge. Recently, integrating high-throughput experimentation (HTE) with machine learning (ML) aims to achieve a more systematic catalyst design without relying on specific knowledge or assumptions about the target catalysis. As a first step, this study constructs an unbiased HTE dataset for dry reforming of methane (DRM) at 500 °C on 256 γ-Al2O3-supported multi-element catalysts, prepared by randomly combining 17 elements selected from the periodic table without any preconceptions. The obtained data and selected catalysts are analyzed in various ways to gain insights into catalyst design and catalysis. It is found that the inclusion of Ni or platinum group elements does not necessarily lead to DRM activity; rather, careful combinations of elements are crucial. Specifically, the catalysts that exhibit the highest activities are not only based on Ni as the main active element but also frequently contain Li, Al, and Nb, which are hardly regarded as promoters in the literature. Data scientific analyses also reveal that the coexistence of specific elements such as Al, Nb, and Hf with Ni or Rh promotes catalysis. Studying the best-found Ni-based catalyst elucidates individual elements’ roles in improving activity and suppressing carbon deposition. In particular, the ternary combination of Al, Nb, and Hf reduces carbon deposition while enhancing activity. Overall, this study demonstrates the validity of unbiased exploration in providing a foundational dataset for ML and in discovering catalyst design guidelines.
Nickel-Catalyzed Stereospecific Alkylation of Vinylsiloxanes Using Pyridinium salts
Authors: Salamone Logan , Vanderbiest Xavier , Riant Olivier
Published: October 2024

A methodology for radical cross-coupling with vinylsiloxanes and pyridinium salts under nickel catalysis is described. Easily implemented from inexpensive and abundant primary amines and terminal alkynes, this modern Hiyama coupling provides efficient access to (E), (Z), and 1,1’-alkenes with configuration retention. Operating under mild conditions, this robust strategy applies to a broad range of functional groups with diverse double bond stereochemistries. This versatile reaction is scalable and straightforward, accommodating both secondary and primary alkyl groups. A radical mechanism involving hypervalent silicon intermediates is proposed.
Active Learning Guided Hit Optimization for the Leucine-Rich Repeat Kinase 2 WDR Domain Based on In Silico Ligand Binding Affinities
Authors: Gusev Filipp , Gutkin Evgeny , Gentile Francesco , Ban Fuqiang , Koby S. Benjamin , Li Fengling , Chau Irene , Ackloo Suzanne , Arrowsmith Cheryl H. , Bolotokova Albina , Ghiabi Pegah , Gibson Elisa , Halabelian Levon , Houliston Scott , Harding Rachel J. , Hutchinson Ashley , Loppnau Peter , Perveen Sumera , Seitova Almagul , Zeng Hong , Schapira Matthieu , Isayev Olexandr , Cherkasov Artem , Kurnikova Maria G.
Published: October 2024

The leucine-rich repeat kinase 2 (LRRK2) is the most mutated gene in familial Parkinson’s disease, whose mutations lead to pathogenic hallmarks of the disease. The LRRK2 WDR domain is an understudied drug target for Parkinson’s disease with no known inhibitors prior to the first phase of the Critical Assessment of Computational Hit-Finding Experiments (CACHE) Challenge. CACHE challenges are designed to attract state-of-the-art computational methods for both hit-finding and lead optimization of small molecule inhibitors to challenging protein targets. A unique advantage of the CACHE challenge is that the predicted molecules are experimentally validated in-house. Here we report on our winning submission of experimentally confirmed LRRK2 WDR inhibitor molecules, predicted from thermodynamics integration (TI) calculations performed on only 672 compounds within a chemical space of 25,171 molecules. We used a free energy molecular dynamics (MD) -based active learning (AL) workflow to optimize our two previously confirmed hit molecules. We identified 8 experimentally verified novel inhibitors out of 35 tested (23% hit rate) with a maximum affinity increase of almost 35-fold. These results demonstrate the efficacy of free energy-based active learning workflow to quickly and efficiently explore large chemical spaces while minimizing the number and length of computational simulations. This workflow is widely applicable to the screening of any chemical space for small molecule analogs with increased affinity, subject to the general constraints of RBFE calculations. The mean absolute error of TI MD calculations was 1.30 kcal/mol with respect to measured KD of hit compounds.
THEMATIC PROGRAMS (TELEVISION) AND PERIODICALS ABOUT THE CULTURE OF THE PERIOD OF KAZAKHSTAN’S INDEPENDENCE
Authors:   AL-FARABI KAZAKH NATIONAL UNIVERSITY, Nurash Aidana , Rozhkov Aleksandr
Published: October 2024

The relevance of the topic of this scientific work lies in the fact that in the context of globalization the national media in Kazakhstan will have to solve the problem of consolidating society by preserving the cultural identity of the Kazakh people with its rich cultural heritage and potential. Analysis of the ac- tivities of media resources and the problems of the industry will make it possible to improve the cultural policy of the state and make culture an effective tool for the formation of national ideology and value orientations of citizens. The purpose of the study is to formulate trends and features of the development of Kazakh mass media about culture in the post-Soviet period. The methodological basis of scientific work was built based on a combination of such methods of cognition as comparative, historical, forecast- ing, structural-functional and classification. The main results of the research work consist in analyzing the process of creating qualitatively new media in Kazakhstan in the post-Soviet period, assessing the influ- ence of Kazakh media resources on the formation of cultural priorities of citizens, formulating prospects for improving the industry press in the context of recognizing culture as a factor in the development of society. In addition, the work examined the mechanisms for forming the state’s cultural policy, among which one of the key places is the widespread use of information technologies in the field of culture, and also studied the main topics of television programs and the genre diversity of cultural periodicals. The materials of the work can be applied in research fields: the work can be useful for scientists whose areas of interest include the development of journalism in Kazakhstan in the post-Soviet period, as well as for civil servants of the country implementing policies in the cultural sphere.
THE INFORMATION AGENDA IN CHINA AND KAZAKHSTAN: COMPARATIVE ANALYSYS
Authors:   AL-FARABI KAZAKH NATIONAL UNIVERSITY, Mukhtar Lazzat , Sun Yuting
Published: October 2024

The relevance of the study lies in the fact that the quick digitalization of contemporary society im- pacts the processes linked to the production, dissemination, and consumption of news material. Differ- ent media, social, and political entities impact each other and shape different agendas, making it crucial to conduct a comparative analysis of various information agendas. The main purpose of this article is to compare and analyze the information agendas of China and Kazakhstan, shedding light on how they are currently being shaped in both nations. The significance of this research is in the theoretical and practical examination of agenda formation in new media as opposed to traditional media. The research’s theoretical importance broadens current concepts on how the information agenda is shaped in contemporary society. The concepts and findings from the research can be helpful for analyz- ing the details of election periods, news media articles, and the regional media environment. The practical significance of the work lies in its practical application in shaping information policies for public organizations, authorities and local governments in China and Kazakhstan. The research methodology involves tracking the press releases of Kazakhstani and Chinese print media, calculating statistical indicators and conducting comparative analysis. In the conclusion, it was found by the authors that the media landscape has been altered due to the rise of new media. An immediate update of the research methodology that drives the agenda is needed to change the way information is distributed. The significance of the thorough comparative analysis conducted lies in its aim to enhance regional integration and cooperation by establishing a system for cross-border collaboration that fosters the shar- ing of information. This can be done by establishing regional news organizations or media partnerships that collaborate on regional information priorities.
Identifikasi Candida Sp. Pada Air Bak Toilet Umum Di Pasar Tradisional
Authors: Putra Anak Agung Ngurah Dwi Tisna Adi , Habibah Nur , Dhyanaputri I Gusti Ayu Sri
Published: October 2024

Toilet merupakan sarana sanitasi yang penting dan dapat menjadi salah satu tempat penyebaran penyakit. Salah satu jenis penyakit yang dapat menyebar melalui toilet adalah penyakit akibat infeksi jamur yang disebabkan oleh Candida sp. Jamur Candida sp. memiliki sifat patogen yang dapat menyebabkan penyakit oportunistik yaitu kandidiasis. Kontaminasi Candida sp. pada air bak toilet dapat disebabkan oleh berbagai sumber, antara lain kontaminasi dari sumber air, kontaminasi dari pengunjung serta kontaminasi dari lingkungan sekitar toilte. Selain itu frekuensi pembersihan dan pengurasan juga dapat berpengaruh terhadap penumpukan jamur adalah Candida sp pada air bak toilet. Penelitian ini merupakan penelitian deskripstif yang bertujuan untuk mengisolasi dan mengidentifikasi Candida sp. pada air bak toilet umum di Pasar Tradisional Kecamatan Denpasar Barat. Sampel dalam penelitian ini adalah air bak toilte yang diperoleh dari 31 bak toilet umum di kawasan pasar tradisional. Sampel air bak toilet dikultur pada media SDA lalu koloni yang tumbuh diidentifikasi secara mikroskopis dedngan pewarnaan LPCB dan dilakukan uji germ tube. Hasil penelitian menunjukkan bahwa dari 31 sampel diketahui bahwa sebanyak 15 sampel (48,4%) positif mengandung Candida sp. dan 2 sampel diantaranya teridentifikasi merupakan Candida albicans berdasarkan uji germ tube. Hasil positif tersebut berkaitan erat dengan kondisi toilet umum dan kebersihannya yang meliputi frekuensi pemersihan dan pengurasan bak air, penggunaan cairan disinfektan dan sumber air yang digunakan.
Innovative strategies in pediatric drug development
Authors: Asghar Mehdi , Rehan Haider , Geetha Kumari Das , Zameer Ahmed , Sambreen Zameer
Published: October 2024

The incidence of pediatric drugs poses unique challenges due to the distinct corporal, pharmacokinetic, and pharmacodynamic characteristics of juveniles. Innovative methods are being developed to address these challenges and ensure the safety and efficacy of pediatric treatments. This paper investigates various approaches to improve pediatric drug handling, including the implementation of age-appropriate formulations, the use of advanced drug delivery systems, and the incorporation of real-world evidence and patient-centric models in clinical trials. Additionally, regulatory frameworks and procedures that support pediatric drug development are examined, emphasizing the roles of initiatives such as the Pediatric Research Equity Act (PREA) and the Best Pharmaceuticals for Children Act (BPCA) in the United States, as well as similar efforts in Europe and other regions. Emphasis is placed on collaborative efforts among key stakeholders: manufacturers, academia, regulatory bodies, and patient advocacy groups, to promote change and address unmet medical needs in pediatric populations. Furthermore, this paper discusses the potential of emerging technologies, particularly artificial intelligence and genomics, to transform pediatric drug development. By leveraging these innovative strategies, the pharmaceutical industry can enhance treatment outcomes for children and advance pediatric healthcare.
Pediatric drug formulation
Authors: Rehan Haider , Asghar Mehdi , Geetha Kumari Das , Zameer Ahmed , Sambreen Zameer
Published: October 2024

Pediatric drug expression presents different challenges and freedoms on account of the singular corporeal traits and enlightening stages of adolescents. Developing age-appropriate formulations makes necessary a deep understanding of pediatric pharmacokinetics and pharmacodynamics, in addition to the security and productiveness characterizations of cures. This paper surveys the standards and practices complicated in pediatric drug expression, stressing the significance of the portion of the drug or other consumable veracity, palatability, and ease of presidency. It reviews differing portions of drugs or other consumable forms, containing spoken fluids, capable of disintegration tablets, and tiny tablets, and focal points the act of excipients in guaranteeing balance and reputation. Additionally, this paper addresses supervisory directions and the importance of including pediatric subjects and caregivers in the expression process to embellish devotion and healing effects. By checking current progress and case studies, this paper underlines the distracting need for tailor-made pediatric formulations to correct pediatric healthcare conditions. Future guidance in pediatric drug expression is labeled, accompanying a devoted effort to change the way that 3D publication, novel childbirth methods, and embodied cure approaches. This paper aims to determine an inclusive survey of pediatric drug expression, contribution observations, and methods for optimizing drug analysis.
Effect of different infusion temperatures towards the phenolic content,
antioxidant and α-amylase inhibitory activities of okra (Abelmoschus esculentus)
infusion water
Authors: Choy L.X. , Liew J.Y. , Sim K.Y.
Published: October 2024

Okra (Abelmoschus esculentus) or lady finger is one of the famous vegetable plants used
in cooking or as an alternative to treat illnesses related to high blood sugar. This study
focused on the effect of different infusion temperatures on the total phenolic content
(TPC), antioxidant (2,2-diphenyl-1-picrylhydrazylradical (DPPH) radical scavenging and
total antioxidant activity (TAA)) and α-amylase activities of okra infusion water. The okra
infused in water at 60°C had the highest TPC (49.41±1.09 mg GAE/L sample), while the
okra infused in water at ambient temperature exhibited the lowest TPC (14.03±1.23 mg
GAE/L sample). A similar trend was observed in both the DPPH radical scavenging and
TAA of the okra samples. A strong correlation was found between the TPC, DPPH (r =
0.927) and TAA (r = 0.938). However, the α-amylase activity of the samples was not in
line with the increase in infusion temperature, as it recorded 47.95±1.77% when treated at
ambient temperature. This study revealed that the chemical contents of the okra infusion
water were influenced by different infusion temperatures. Future studies emphasize the
detailed elucidation of antioxidant and antidiabetic profiles of the okra infusion water
extract to unleash its potential for stress oxidative and anti-hyperglycemia effects.
Beş Faktör Kişilik Özelliklerinin Psikolojik İyi Oluşa Etkisi (The Effect of Five Factor Model of Personality Traits on Psychological Well-being)
Authors: Kaya Yasemin , Çolak Seda
Published: October 2024

Bu çalışmanın amacı beş faktör kişilik özellikleri ile psikolojik iyi oluş arasındaki ilişkileri incelemektir. Çalışmada veri toplama yöntemi olarak anket kullanılmıştır. Kolayda örnekleme yöntemi ileyapılan araştırmandabir devlet üniversitesindelisans ve önlisans öğrencilerinden seçilen 193 kadın, 118erkekolmak üzeretoplam311 öğrenciaraştırmanın katılımcılarınıoluşturmaktadır. Öğrencilerden kişilik özelliklerine göre anketi doldurmaları istenmiş, elde edilen veriler doğrulayıcı faktör analizi, korelasyon ve regresyon analizleri yardımıyla incelenmiştir. Beş faktör kişilik özelliklerinin psikolojik iyi oluşa etkisine yönelik yapılan analizler ile,beş faktör kişilik özelliklerinden dışadönüklük, sorumluluk, uyumluluk ve yeniliğe açıklık özelliklerininöğrencilerin psikolojik iyi oluşlarına pozitif ve anlamlı yönde bir etkisinin olduğu, ayrıca beş faktör kişilik özelliklerinden nevrotikliğin ise öğrencilerin psikolojik iyi oluşları üzerinde negatif ve anlamlıbir etkisi olduğu sonucuna varılmıştır.
Hybridization of Pubic Values and Participatory Social Problem Solving
Authors:   The Korea Association Of Governance Studies, Hwang Joungyoon , Jang Yong Suk
Published: October 2024

This study aims to empirically analyze the factors that influence individual citizens' participation in solving social problems. We employed the data from Social Value Survey conducted by the Center for Social Value Enhancement Studies (CSES). The findings showed that individuals with a more value-integrative mindset tend to be more active in participating in social problem-solving activities and engage in a wider range of such activities compared to those without this mindset. Additionally, the impact of these attitudes was more significant in direct participation in activities that address social issues. These results imply that institutional frameworks should be designed to facilitate citizen engagement in resolving social problems. This work highlights the need for a broader and more comprehensive policy approach to effectively tackle social issues.
A Methodological Study of the Economic Evaluation of Implementing Domestic Drug Courts: A Systematic Review
Authors:   The Korea Association Of Governance Studies, Nam Kyung-ae , Park Sun-Kyeong
Published: October 2024

This study proposes a systematic literature review methodology for the economic evaluation of drug courts, considering the rising number of drug-related offenders in South Korea. Drug courts aim to reduce drug use and recidivism by providing mandatory treatment instead of incarceration. We conducted a systematic literature review using six databases to extract methods of economic evaluation, participant characteristics, and recidivism outcomes. We applied the Quality of Health Economic Studies (QHES) instrument and the Maryland Scientific Methods Scale (SMS) to assess the quality of economic evaluations and recidivism outcomes, respectively. Among the twelve studies reviewed, the majority were from the United States (n = 11), employing cost-benefit analysis from the taxpayer’s perspective (n = 10), while one Australian study used a cost-effectiveness analysis from the treatment provider’s perspective. The U.S. studies scored below 80 on the QHES, whereas the Australian study scored 86.5. Both countries demonstrated effective recidivism prevention, according to SMS scores. In the United States, the average cost savings per participant was approximately $5000, and in Australia, the cost to reduce one drug crime was 1905 AUD. These findings suggest that a thorough economic evaluation of drug courts in South Korea should involve estimating per-participant cost savings from the taxpayer’s perspective and predicting participant numbers. Furthermore, a thorough review of the health status differences between drugs and the economic impact of alternative programs is required.
Proteogenomic profiling of lung adenocarcinoma reveals therapeutic targets for precision medicine
Authors: Elmas Abdülkadir
Published: October 2024

Lung cancer is the leading cause of cancer-related fatalities worldwide, impacting both men and women. A major challenge is its frequent diagnosis at advanced stages, which limits treatment options. While genomic and transcriptomic analyses have traditionally been used to identify potential drug targets, there remains an unexplored potential in targeting protein-level anomalies. This study systematically investigates the proteomic landscape of 109 primary lung adenocarcinoma (LUAD) tumors using comprehensive mass-spectrometry (MS) proteomics data. By focusing on kinases, the key actors in oncogenic signaling pathways, we aim to find new therapeutic targets for LUAD. Through intricate analyses encompassing tumor-normal differentials and inter-tumor variations, our study identifies notable overexpressed targets, including PLAU, MET, ERBB2, EGFR, PDK1 kinases, and THBS2, CRABP2, INPP4B proteins, many of which present no evidence of transcriptomic alteration. Several targets we identified through proposed approaches have corresponding inhibitor drugs, including ERBB2 kinase (Afatinib) and VEGF-A protein (Bevacizumab). Our findings validate known therapeutic markers in lung cancer and reveal candidate protein targets specific to LUAD, underscoring the efficacy of proteomic methodologies in advancing precision medicine for cancer.
Developing a Classic Turn-Based RPG: The Making of 'Waduh! Aku Pergi Ke Isekai' with RPG Maker MV
Authors: Retno Sujacka
Published: October 2024

The game "Waduh! Aku Pergi ke Isekai" is a classic Role Playing Game (RPG) developed using RPG Maker MV. It tells the story of a young man named Makecar who is suddenly summoned to another world by a Goddess to defeat a Demon God threatening the world's destruction. The game combines classic RPG elements such as a Standard Turn-Based battle system, open-world exploration, and a variety of main and side quests, offering players diverse gameplay experiences. RPG Maker MV was chosen for its ease of use, even for beginner developers, utilizing a graphical user interface and simplified JavaScript scripting. Testing of the game shows that "Waduh! Aku Pergi ke Isekai" provides a deep and challenging gameplay experience, while also highlighting the potential of RPG Maker MV as an effective platform for independent game development. This game aims to inspire other game developers to create similar creative and original games.
Gamification in Education: Implementing the Donuts Catcher Game Using Scratch
Authors: Afriani Rinah , Suwari Ana
Published: October 2024

The advancement of technology and gamification in education increasingly showcases the potential to create interactive and enjoyable learning experiences. This study develops the Donuts Catcher game using Scratch, a visual programming platform designed to simplify the creation of games and animations. The game is designed as an educational tool to teach basic programming concepts while providing entertainment for players. In this game, players use a bowl to catch falling donuts, with each successfully caught donut adding points to the player's score. The game ends when the player reaches a maximum score of 100 points. The development process involves designing sprites, backgrounds, and coding interactive and educational game logic. Testing the game demonstrates that Donuts Catcher can be an effective tool for introducing programming to beginners in a fun and easily understandable way. The game also provides engaging gameplay for children, with a simple design that motivates them to keep playing and learning.
TEXTILE UPCYCLING FOR SUSTAINABLE FASHION: A CASE STUDY FROM NIFT SHILLONG
Authors: Das Rimi , Gupta Meenakshi
Published: October 2024

The Northeast region of India, renowned for its abundant cultural variety, is home to a vivid drapery of traditional textiles essential to maintaining that diversity's spirit. With their combination of generations-old indigenous designs, materials, and techniques, these textiles are a living tribute to the North East's rich cultural inheritance. The North East has been a melting pot of varied tribes for generations, creating a cultural fusion where several tribal groups speak different languages, uphold their ancient rituals, maintain independent economies, and produce one-of-a-kind crafts and fabrics. In the past, when there were no other ways to verify a person's goods and familial responsibilities, these textiles frequently functioned as identity cards. This paper will take you on a tour of the North East's elaborately woven clothing and its way of draping the rectangular unstitched textile to make it look like apparel, many of which still exist today. The clothing, which is mostly made of unstitched fabric and is worn in various elegant, opulent, innovative, and different ways, gives rise to a distinct style and greatly influences how modern women dress. This paper will stress the importance of traditional textile apparel of the North East and explore how new traditions have been created by transferring artistic ideas through upcycling the present woven textile by using a zero-waste pattern method by the students of the fashion design department for sustaining the textile and styling to suit the tastes of the adopting lifestyle. The effort provided the students with a future business opportunity, alternative sources of cheaper materials, enriched creativity, and fun. The results revealed a noticeable change in the students’ approaches toward material usage and design methodology.
PRESERVING TRADITION IN TRANSITION: EXPLORING IRON SMELTING AND CAREER DYNAMICS IN THE AGARIA COMMUNITY
Authors: Kanungo Manjari , Kapoor Shikha , Mithapalli Amar , Solanki Divya
Published: October 2024

Rural India preserves the age-old traditional crafts and the ways of creation pass on from the older to the younger generations. This study represents the traditional iron smelting craft of the Agaria tribe of Madhya Pradesh. The Agaria tribe of Madhya Pradesh are experts at manufacturing a variety of products through traditional methods of iron smelting since the Vedic period. It emphasizes the relationship between their craftsmanship, livelihood, and the changing goals of the younger generation. The study examines the cultural and economic significance of iron smelting in the Agaria community throughout history. It also looks into the noticeable change in recent years, with the community's younger generation increasingly pursuing other career options rather than continuing with the traditional craft. This shift raises concerns about the implications of cultural heritage in the face of modern economic realities. It may impact the viability and future of Agaria iron smelting. The empirical research method was employed for data collection through well-structured interviews of 50 artisans and allied workers of Agaria craft. The research provides insights into the processes at work and proposes recommendations for striking a balance between tradition and adaptation within the Agaria community to prevent the younger generations from abandoning the traditional Agaria craft.
PORTABLE PARTITIONS – A SUSTAINABLE ALTERNATIVE FOR WALLS IN INTERIOR DESIGN
Authors: Adil Afroz , Soni Gunja , Bhatore Vijeta
Published: October 2024

Shelter is a basic necessity of a human being. Humans need an enclosed space to live and work. Interior designing is an industry to design these enclosed spaces. Interior designing is designing a built-up area; it can be an office, residence, shopping complex, multiplex, restaurant, hotel, hospital, schools, colleges and many more. Interior designing is a flourishing discipline that utilizes a lot of natural resources and is also responsible for creating a huge amount of waste that harms the environment. So, the designers are shifting towards sustainability as the natural resources are getting exhausted. Designers are working for sustainability by choosing vernacular materials, opting for natural construction techniques, reducing the usage of plastic, concrete, and other harmful raw materials, etc. Increase in population is leading to migration towards cities for better education, healthcare facilities and job opportunities. This migration is posing a lack of horizontal building space in the cities giving rise to smaller interior spaces. It is the design and art of the interior designer to provide all the amenities with proper functioning and aesthetics in the constrained space. Fixed walls in the interiors take up a lot of built-up area and require a lot of time and resources for their construction. Light weight portable partitions can be a sustainable alternative to replace these fixed walls. This study focuses on portable partitions that provide space flexibility but retain the qualities of fixed walls by providing privacy and maintaining the aesthetics of the space.For this study primary and secondary data have been collected. Interior designers were contacted and were asked to answer a questionnaire based on portal partitions, their benefits, and the way in which they can prove to be a sustainable alternative. The primary and secondary data so collected was analyzed and results were drawn. Certain suggestions are discussed to increase the concept of sustainability in interior designing and lastly, based on the results and suggestions, conclusions have been drawn.
Enerji Güvenliği ve Jeopolitik Riskin Türkiye'nin Çevre Kalitesi Üzerindeki Rolü: Yeni Nesil Fourier Terimli Genişletilmiş ARDL Modelinden Kanıtlar
Authors: Daştan Muhammet
Published: October 2024

Küresel ısınmaya bağlı olarak; yoğun yağışlar, fırtınalar ve aşırı kuraklıklar da dahil olmak üzere birçok çevresel felaketin yaşandığı günümüz dünyası, Rusya-Ukrayna Savaşı ve İsrail’in Filistin’i işgali gibi beklenmedik jeopolitik gelişmelere tanıklık etmektedir. Tüm bu gelişmeler, ülkelerin ekonomik aktivitelerini, enerji stratejilerini ve nihayetinde çevresel kalitelerini etkilemede önemli bir potansiyele sahiptir. Dolayısıyla bu çalışma, jeopolitik risk, enerji güvenliği ve çevre kalitesi arasındaki ilişkileri Türkiye özelinde 1973-2018 dönemi için analiz etmeyi amaçlamaktadır. Bu amaçla çalışmada, çevresel kalitenin bir göstergesi olarak yük kapasite faktörü kullanılmakta, enerji güvenliği ve jeopolitik riskin yanı sıra ekonomik büyüme, beşeri sermaye ve doğal kaynak rantının çevresel etkileri de dikkate alınmakta ve Fourier terimli genişletilmiş ARDL yaklaşımı uygulanmaktadır. Ampirik bulgular, jeopolitik risk ile enerji güvenliğinin çevre kalitesini olumsuz yönde etkilediğini göstermektedir. Sonuçlar ayrıca ekonomik büyüme ve doğal kaynak rantının çevre kalitesini düşürdüğünü, beşeri sermayenin ise çevre dostu bir faktör olduğunu ortaya koymaktadır.
PRECARIEDADES NA EDUCAÇÃO ESCOLAR EM REASSENTAMENTOS DE HIDRELÉTRICAS NA AMAZÔNIA
Authors: SILVA Jeferson Cardoso da , MORET Artur de Souza
Published: October 2024

O objetivo geral desta pesquisa foi investigar quais as consequências da precariedade ou inexistência da educação escolar nos sete (07) reassentamentos criados para alocar os deslocados da implantação das Hidrelétricas no Rio Madeira, em Porto Velho/RO. Foram entrevistados noventa e três (93) indivíduos desses reassentamentos através de um questionário semiaberto, com análise quantitativa e qualitativa. Os resultados indicam não haver diferença significativa que aponte melhorias na educação escolar e, as consequências da precariedade ou inexistência da educação escolar produziu risco e vulnerabilidade que se traduzem na atual condição de não reconfiguração socioterritorial dos reassentamentos.
COINFECÇÃO POR Mycobacterium tuberculosis E MICOBACTÉRIAS NÃO TUBERCULOSAS (NTM): RELATO DE CASO
Authors: Sartori Leticia Stephanie Pereira Borges , fachini eduarda montebeller , Almeida Atinele Rodrigues Oliveira De , Silvestro Elessandra Maria
Published: October 2024

As infecções pulmonares por micobactérias não tuberculosas (MNT) estão frequentemente associadas a condições pulmonares preexistentes. O diagnóstico clínico desta patologia é fundamentado na presença
Ecologia Integral
Authors: Lima Adriano Sousa , Bezerra Cícero Manoel
Published: October 2024

A cultura da indiferença convive com crises climáticas cada vez mais intensas e mais próximas umas das outras. Ser indiferente, nesse sentido, potencializa os resultados desastrosos das tragédias climáticas. Jamais o planeta-terra havia sido tão devastado pela ação humana e, dessa forma, o “pálido ponto azul” corre o risco de se extinguir.
Resultado das pesquisas de teólogos e teólogas, o livro “Ecologia integral: uma interface entre fé e vida” apresenta dez ricos capítulos que procuram não somente a aproximação entre as temáticas da teologia e do meio-ambiente, mas, também, formas pelas quais se deveria reconstruir uma nova narrativa teo-ambiental em simultaneidade com práticas transformadoras que revertam os danos do insano comportamento humano.
Análise Estrutural, Imunohistoquímica e Biomecânica de Diferentes Membranas Biológicas de Origem Bovina
Authors: Menezes Ramayana Ortiz de Sá , Godinho Ana Bárbara Freitas Rodrigues , Pereira Emmanuel Santos Forte , Carvalho Eulogio Carlos Queiroz de , Silveira Leonardo Serafim da , Carvalho Eduardo Atem de
Published: October 2024

Os biomateriais são utilizados para aumentar ou substituir tecidos danificados no corpo. O principal biomaterial usado com fins terapêuticos é o colágeno, por intermédio de membranas biológicas, como
Cassava production and agricultural growth in Nigeria: Analysis of effects and forecast
Authors: Omoluabi, J.E.  , Ibitoye, S.J.
Published: October 2024

This study analyzed the trend in agricultural growth and cassava productivity in Nigeria (1961 – 2020). Time series on variables of interest were sourced from the Central Bank of Nigeria (CBN) statistical bulletin, the National Bureau of Statistics (NBS), and FAOSTAT. The secondary data obtained were analysed Vector Error Correction Model (VECM) and the autoregressive integrated moving average (ARIMA) model. The result of the short-run model indicated that the Vector Error Correction Term [VECT (-1)] was rightly signed (-1.74) indicating a high speed of adjustment. The results of the ARIMA forecast showed that in the next decade, the area cultivated for cassava will be 11295.04 (‘000 hectares), the output of cassava will be 73300.33 (‘000 tonnes), the yield of cassava will be 10.98 tonnes/ha while agricultural growth will be 80612.60 (‘000). The findings are compelling reasons for encouraging cassava production for sustainable food production in Nigeria as it is a versatile staple to address food security in Nigeria.
Explainable AI in financial technologies: Balancing innovation with regulatory compliance
Authors: Andrew Nii Anang  , Oluwatosin Esther Ajewumi  , Tobi Sonubi  , Kenneth Chukwujekwu Nwafor  , John Babatope Arogundade  , Itiade James Akinbi
Published: October 2024

As artificial intelligence (AI) technologies increasingly permeate the financial sector, their adoption raises significant challenges and opportunities regarding regulatory compliance and innovation. This paper explores the critical role of Explainable AI (XAI) in balancing these two aspects, particularly in applications such as fraud detection, credit scoring, and algorithmic trading. We highlight the necessity of XAI for financial institutions to meet regulatory requirements that demand transparency and accountability in AI-driven decisions. The discussion delves into the complexities faced by these institutions, including the inherent biases in algorithms that can compromise fairness and the ethical implications of opaque decision-making processes. Through case studies of successful XAI implementations, we illustrate how transparency can enhance consumer trust and promote a more robust regulatory environment. This examination underscores the importance of fostering innovation while adhering to compliance mandates, providing a roadmap for financial institutions striving to leverage AI responsibly. Ultimately, we advocate for the integration of XAI as a means to mitigate risks associated with algorithmic bias and enhance the integrity of financial technologies, thereby contributing to a more equitable financial landscape.
Hubungan Pola Konsumsi Sayur Buah terhadap Frekuensi ISPA dan Status Gizi Balita Desa Randuboto
Authors: Hediana Zalzabila , Rahma Amalia , Mulyani Endah
Published: October 2024

Asupan nutrisi, ciri-ciri tubuh yang unik, dan faktor lingkungan semuanya berkontribusi terhadap status gizi seseorang, yang pada gilirannya menunjukkan kesehatan mereka secara umum. Infeksi saluran pernafasan akut hanyalah salah satu contoh bagaimana penyakit dapat berdampak pada kesehatan seseorang. Buah-buahan dan sayuran adalah cara terbaik untuk mencegah ISPA dan masalah gizi karena kaya akan vitamin, mineral, dan serat. Kondisi gizi masyarakat Desa Randuboto, Kecamatan Sidayu, Gresik, serta pola makan buah dan sayur terkait ISPA menjadi fokus utama penelitian ini. Dengan desain cross-sectional, penelitian kuantitatif ini melibatkan 152 balita. Dua alat yang digunakan: Kuesioner Frekuensi Makanan (FFQ) dan Penarikan Kembali 24 Jam. Temuan menunjukkan bahwa baik hubungan antara ISPA (p=0,493) maupun status gizi (p=0,678) maupun pola asupan sayur tidak berkorelasi signifikan satu sama lain menggunakan uji korelasi Spearman. Meskipun tidak ditemukan korelasi yang signifikan secara statistik antara pola konsumsi buah dan status gizi (p=0,502), terdapat korelasi yang signifikan antara pola konsumsi buah dan ISPA (p=0,048). Hubungan antara ISPA dan status gizi mungkin lebih kompleks dari sekedar frekuensi orang makan buah dan sayur; area ini mungkin memerlukan penyelidikan lebih lanjut.
HUBUNGAN KONSUMSI FAST FOOD DAN AKTIVITAS FISIK DENGAN STATUS GIZI MAHASISWI FAKULTAS KESEHATAN UNIVERSITAS MUHAMMADIYAH GRESIK
Authors: Jannah Miftahul , Supriatiningrum Dwi Novri , Sholikhah Desty Muzarofatus
Published: October 2024

Obesitas merupakan masalah kesehatan umum di seluruh dunia, bahkan di negara-negara berkembang seperti Indonesia. Hal ini mempengaruhi negara-negara kaya dan berkembang. Di antara populasi yang kurang aktif, sebanyak 80% penduduk Indonesia termasuk dalam kategori tersebut. Tujuan penelitian ini adalah untuk mengetahui hubungan asupan fast food dosen perempuan, tingkat aktivitas fisik, dan status gizi di Universitas Muhammadiyah Gresik. Penelitian observasional analitik dengan menggunakan prosedur basic random sampling dilakukan dengan sampel delapan puluh empat siswi. Formulir FFQ, formulir penarikan kembali makanan (diisi satu kali setiap 24 jam), formulir aktivitas fisik, dan pengukuran status gizi digunakan untuk mengumpulkan data. salah satu metode untuk mengevaluasi prosedur adalah tes spearman. Berdasarkan data yang telah disebutkan sebelumnya, dapat disimpulkan bahwa terdapat hubungan antara asupan energi dengan gizi marco, namun tidak terdapat hubungan antara aktivitas fisik dengan status gizi. Penelitian ini juga menemukan adanya korelasi antara asupan protein pada α=0,000, asupan lemak pada α=0,000, dan perilaku rutin makan pada α=0,000, serta konsumsi makanan cepat saji.
PEMBERIAN PAKAN IKAN NILA (Oreochromis niloticus) DENGAN PENAMBAHAN EKSTRAK ETANOL TEPUNG RUMPUT LAUT (Kappaphycus alvarezii) PADA PERBANDINGAN KONSENTRASI PELARUT YANG BERBEDA
Authors: Lumbessy Salnida Yuniarti , Wahyunyngsyh Tri , Abidin Zaenal
Published: October 2024

This study aims to analyze the effect of providing commercial feed with the addition of ethanol extract of K. alvarezii seaweed flour on the growth of tilapia (O. niloticus).  The research was carried out in July – October 2023 at the Aquaculture Reproduction Laboratory, Faculty of Agriculture, Mataram University. The method used in this study was an experimental method using a completely randomized design with 4 treatments and 3 replications, namely : commercial feed (control/P1), 96% ethanol extract 1:3 (P2), 96% ethanol extract 1:4 (P3), and ), 96% ethanol extract 1:5 (P4). Extraction was carried out by macerating K. alvarezii seaweed flour for 30 hours, then filtering and evaporating at 40 oC until an extract was produced in liquid form. The extract is mixed with feed at a rate of 2 g/kg feed. Before being given to feed, the extract is mixed first with 10 ml of distilled water. The tilapia seeds used measure 4 – 5 cm with a stocking density of 1 fish/liter. Fish rearing is carried out for 50 days, with a feeding frequency of 5% of the total weight of the fish and done 3 times a day. The test parameters are absolute weight, absolute length, specific growth rate (SGR), feed conversion (FCR), feed utilization efficiency, survival (SR) and water quality, which includes temperature, pH and DO. Data were analyzed using ANOVA and Duncan test at significant level of 0.05. The research results showed that the addition of K. alvarezii ethanol extract to tilapia feed can influence growth, feed utilization efficiency, feed convention rate (FCR), and survival rate (SR) of tilapia. The addition of K. alvarezii ethanol extract 1:5 to the feed showed the best results because it could increase the growth and utilization of tilapia feed with a survival rate of tilapia of 83%.
TINGKAT KESUKAAN BAKSO IKAN DARI BERBAGAI BAHAN BAKU UTAMA DAGING IKAN PELAGIS BESAR
Authors: Junianto Junianto , Nurerlindajava Visivalery , Zaidan Kemas Ahmad Akasyah , Pranata Gibran Amalio
Published: October 2024

In the research conducted to assess the preference levels for fish meatballs made from various main ingredients, specifically pelagic fish such as tuna, mackerel, and skipjack, the study aimed to determine the preference for fish meatball products using large pelagic fish as the main ingredient, namely tuna, mackerel, and skipjack. Through a hedonic test, with results analyzed using the Friedman test, it was found that the panelists preferred fish meatballs made with mackerel as the main ingredient in terms of appearance, aroma, texture, and taste. The average scores for appearance were 5.93, for aroma 6.2, for texture 4.73, and for taste 5.4, which was the second highest after skipjack fish meatballs.
PENAMBAHAN FERMENTASI DAUN LAMTORO (Leucaena leucocephala) PADA PAKAN UNTUK PERTUMBUHAN DAN KELANGSUNGAN HIDUP IKAN LELE SANGKURIANG (Clarias gariepinus)
Authors: Hoerunnisa Yasna , Rudi Mad , Rouf Ahmad Beni
Published: October 2024

Lamtoro leaves (Leucaena leucocephala) are used as feed ingredients because they contain a lot of protein but are hampered by the high fiber content but can be reduced by fermentation to cover the smell of lamtoro leaves which fish do not like. This research aims to examine the effect of fermenting lamtoro leaves into artificial feed for sangkuriang catfish (C.gariepinus) on the growth and survival of sangkuriang catfish (Clarias gariepinus). This research used 120 Sangkuriang catfish with ± 3 grams and a length of ± 5-6 cm.  This research method uses a quantitative and experimental approach using a Completely Randomized Design (CRD) consisting of four and three replications consisting of control, 10% lamtoro leaf fermentation, 15% lamtoro leaf fermentation, and 20% lamtoro leaf fermentation. The research observation parameters were absolute weight, absolute length, feed conversion, specific growth rate, and survival of sangkuriang catfish (Clarias gariepinus). The results showed that treatment with the addition of fermented lamtoro leaves had no significant effect (P>0.05) on the survival and growth of sangkuriang catfish. The conclusion from this research is that fermentation of lamtoro leaves has no significant effect on the growth and survival of sangkuriang catfish (Clarias gariepinus).
ANALISIS KUALITAS AIR GUNA MENDUKUNG PENGEMBANGAN BUDIDAYA IKAN BERBASIS KERAMBA JARING APUNG (KJA) DI PERAIRAN PANTAI ELAK-ELAK SEKOTONG
Authors: Diniariwisan Damai , Sumsanto Muhammad
Published: October 2024

Elak-elak Beach are a coastal area that is used for tourism and fishing activities in the form of traditional fishing systems. The potential is quite good for cultivation activities, making this area considered quite suitable for developing KJA activities. The aim of this research is to analyze water quality to see the suitability of the area to support marine cage-based fish cultivation development activities. The method used is descriptive with a purposive sampling system, to describe current conditions. The results of water quality measurements show that the temperature range is 30-32 °C, pH 7.6-7.8 and salinity 30 ppt, where these figures indicate a normal range. For DO, the results show >5 mg/l, which means it is suitable for the needs of aquatic biota, especially cultivated biota. Meanwhile, the nutrient content measured through phosphate and nitrate levels also showed quite high results, namely 0.025 – 0.03 mg/l for phosphate and 0.01 – 0.05 mg/l for nitrate. This range of values ​​indicates eutrophic waters, so that overall the Elak-elak Beach water area is good enough for the development of marine cage-based cultivation.