bluuebunny/crossref_metadata_2025 huggingface dataset:
Gene-Specific Genetic Complementation between Brca1 and Cobra1 During Mouse Mammary Gland Development
Authors: Chiang Huai-Chin , Zhang Xiaowen , Zhao Xiayan , Zhang Chi , Chen Jerry , Garza Paula , Smith Sabrina , Ludwig Thomas , Baer Richard J. , Li Rong , Hu Yanfen
Published: February 2018

Germ-line mutations in breast cancer susceptibility gene,BRCA1, result in familial predisposition to breast and ovarian cancers. The BRCA1 protein has multiple functional domains that interact with a variety of proteins in multiple cellular processes. Understanding the biological consequences of BRCA1 interactions with its binding partners is important for elucidating its tissue-specific tumor suppression function. The Cofactor of BRCA1 (COBRA1) is a BRCA1-binding protein that, as a component of negative elongation factor (NELF), regulates RNA polymerase II pausing during transcription elongation. We recently identified a genetic interaction between mouseBrca1andCobra1that antagonistically regulates mammary gland development. However, it remains unclear which of the myriad functions ofBrca1are required for its genetic interaction withCobra1. Here, we show that, unlike deletion ofBrca1exon 11, separation-of-function mutations that abrogate either the E3 ligase activity of its RING domain or the phospho-recognition property of its BRCT domain are not sufficient to rescue the mammary developmental defects inCobra1knockout mice. Furthermore, deletion of mousePalb2, another breast cancer susceptibility gene with functional similarities toBRCA1, does not rescueCobra1knockout-associated mammary defects. Thus, theBrca1/Cobra1genetic interaction is both domain- and gene-specific in the context of mammary gland development.
Evaluation of Serum CEA, CA19-9, CA72-4, CA125 and Ferritin as Diagnostic Markers and Factors of Clinical Parameters for Colorectal Cancer
Authors: Gao Yanfeng , Wang Jinping , Zhou Yue , Sheng Sen , Qian Steven Y. , Huo Xiongwei
Published: February 2018

Blood-based protein biomarkers have recently shown as simpler diagnostic modalities for colorectal cancer, while their association with clinical pathological characteristics is largely unknown. In this study, we not only examined the sensitivity and reliability of single/multiple serum markers for diagnosis, but also assessed their connection with pathological parameters from a total of 279 colorectal cancer patients. Our study shown that glycoprotein carcinoembryonic antigen (CEA) owns the highest sensitivity among single marker in the order of CEA > cancer antigen 72-4 (CA72-4) > cancer antigen 19-9 9 (CA19-9) > ferritin > cancer antigen 125 (CA125), while the most sensitive combined-markers for two to five were: CEA + CA72-4; CEA + CA72-4 + CA125; CEA + CA19-9 + CA72-4 + CA125; and CEA + CA19-9 + CA72-4 + CA125 + ferritin, respectively. We also demonstrated that patients who had positive preoperative serum CEA, CA19-9, or CA72-4 were more likely with lymph node invasion, positive CA125 were prone to have vascular invasion, and positive CEA or CA125 were correlated with perineural invasion. In addition, positive CA19-9, CA72-4, or CA125 was associated with poorly differentiated tumor, while CEA, CA19-9, CA72-4, CA125 levels were positively correlated with pathological tumor-node-metastasis stages. We here conclude that combined serum markers can be used to not only diagnose colorectal cancer, but also appraise the tumor status for guiding treatment, evaluation of curative effect, and prognosis of patients.
Crystal structures of a bacterial dipeptidyl peptidase IV reveal a novel substrate recognition mechanism distinct from that of mammalian orthologues
Authors: Roppongi Saori , Suzuki Yoshiyuki , Tateoka Chika , Fujimoto Mayu , Morisawa Saori , Iizuka Ippei , Nakamura Akihiro , Honma Nobuyuki , Shida Yosuke , Ogasawara Wataru , Tanaka Nobutada , Sakamoto Yasumitsu , Nonaka Takamasa
Published: February 2018

Dipeptidyl peptidase IV (DPP IV, DPP4, or DAP IV) preferentially cleaves substrate peptides with Pro or Ala at the P1 position. The substrate recognition mechanism has been fully elucidated for mammalian DPP IV by crystal structure analyses but not for bacterial orthologues. Here, we report the crystal structures of a bacterial DPP IV (PmDAP IV) in its free form and in complexes with two kinds of dipeptides as well as with a non-peptidyl inhibitor at 1.90 to 2.47 Å resolution. Acyl-enzyme intermediates were observed for the dipeptide complexes of PmDAP IV, whereas tetrahedral intermediates were reported for the oligopeptide complexes of mammalian DPP IVs. This variation reflects the different structural environments of the active site Arg residues, which are involved in the recognition of a substrate carbonyl group, of mammalian and bacterial enzymes. A phylogenetic analysis revealed that PmDAP IV is a closer relative of dipeptidyl peptidases 8 and 9 (DPP8 and DPP9, DPP IV-family enzymes) than DPP IV. These results provide new insights into the substrate recognition mechanism of bacterial DAP IVs and may assist in the development of selective inhibitors for DAP IVs from pathogenic asaccharolytic bacteria, which utilise proteins or peptides as an energy source.
Cerebral ischemia induces the aggregation of proteins linked to neurodegenerative diseases
Authors: Kahl Anja , Blanco Ismary , Jackman Katherine , Baskar Juhi , Milaganur Mohan Harihar , Rodney-Sandy Reunet , Zhang Sheng , Iadecola Costantino , Hochrainer Karin
Published: February 2018

Protein aggregation critically affects cell viability in neurodegenerative diseases, but whether this also occurs in ischemic brain injury remains elusive. Prior studies report the post-ischemic aggregation of ubiquitin, small ubiquitin-related modifier (SUMO) and ribosomes, however whether other proteins are also affected is unknown. Here we employed a proteomic approach to identify the insoluble, aggregated proteome after cerebral ischemia. Mice underwent transient middle cerebral artery occlusion or sham-surgery. After 1-hour reperfusion, prior to apparent brain injury, mice were sacrificed and detergent-insoluble proteins were obtained and identified by nanoLC-MS/MS. Naturally existing insoluble proteins were determined in sham controls and aggregated proteins after cerebral ischemia/reperfusion were identified. Selected aggregated proteins found by proteomics were biochemically verified and aggregation propensities were studied during ischemia with or without reperfusion. We found that ischemia/reperfusion induces the aggregation of RNA-binding and heat-shock proteins, ubiquitin, SUMO and other proteins involved in cell signalling. RNA-binding proteins constitute the largest group of aggregating proteins in ischemia. These include TDP43, FUS, hnRNPA1, PSF/SFPQ and p54/NONO, all of which have been linked to neurodegeneration associated with amyotrophic lateral sclerosis and frontotemporal dementia. The aggregation of neurodegeneration-related disease proteins in cerebral ischemia unveils a previously unappreciated molecular overlap between neurodegenerative diseases and ischemic stroke.
Quantum Clique Gossiping
Authors: Li Bo , Li Shuang , Wu Junfeng , Qi Hongsheng
Published: February 2018

This paper establishes a framework of quantum clique gossiping by introducing local clique operations to networks of interconnected qubits. Cliques are local structures in complex networks being complete subgraphs, which can be used to accelerate classical gossip algorithms. Based on cyclic permutations, clique gossiping leads to collective multi-party qubit interactions. We show that at reduced states, these cliques have the same acceleration effects as their roles in accelerating classical gossip algorithms. For randomized selection of cliques, such improved rate of convergence is precisely characterized. On the other hand, the rate of convergence at the coherent states of the overall quantum network is proven to be decided by the spectrum of a mean-square error evolution matrix. Remarkably, the use of larger quantum cliques does not necessarily increase the speed of the network density aggregation, suggesting quantum network dynamics is not entirely decided by its classical topology.
Wavelength and pulse duration tunable ultrafast fiber laser mode-locked with carbon nanotubes
Authors: Li Diao , Jussila Henri , Wang Yadong , Hu Guohua , Albrow-Owen Tom , C. T. Howe Richard , Ren Zhaoyu , Bai Jintao , Hasan Tawfique , Sun Zhipei
Published: February 2018

Ultrafast lasers with tunable parameters in wavelength and time domains are the choice of light source for various applications such as spectroscopy and communication. Here, we report a wavelength and pulse-duration tunable mode-locked Erbium doped fiber laser with single wall carbon nanotube-based saturable absorber. An intra-cavity tunable filter is employed to continuously tune the output wavelength for 34 nm (from 1525 nm to 1559 nm) and pulse duration from 545 fs to 6.1 ps, respectively. Our results provide a novel light source for various applications requiring variable wavelength or pulse duration.
Plasma Aβ analysis using magnetically-labeled immunoassays and PET 18F-florbetapir binding in non-demented patients with major depressive disorder
Authors: Wu Kuan-Yi , Hsiao Ing-Tsung , Chen Chia-Hsiang , Liu Chia-Yih , Hsu Jung-Lung , Huang Sheng-Yao , Yen Tzu-Chen , Lin Kun-Ju
Published: February 2018

An increased level of brain amyloid deposition and a decreased level of cerebral spinal fluid (CSF) Aβ42 are currently considered reliable biomarkers of Alzheimer’s disease (AD); however, the usefulness of plasma Aβ levels are not well-established. This study investigated the relationships between plasma Aβ levels and cerebral amyloidosis in 36 non-demented patients with major depressive disorder (MDD). All participants underwent 18F-florbetapir PET imaging and provided a blood sample at the same time for immunomagnetic reduction assay to measure the plasma levels of Aβ40 and Aβ42. We found inverse associations of the plasma Aβ42 level and the Aβ42/Aβ40 ratio, and a positive association of the plasma Aβ40 level, with cerebral amyloid deposition in the precuneus, parietal and posterior cingulate cortex. Subgroup analyses in subjects with higher 18F-florbetapir uptake values or MDD with amnestic mild cognitive impairment revealed more pervasive relationships of plasma Aβ measures with 18F-florbetapir binding across the brain regions examined. The study suggested that regional brain amyloid deposition in terms of 18F-florbetapir PET uptake had weak-to-moderate associations with plasma Aβ42 and Aβ40 levels, and the Aβ42/Aβ40 ratio. Validation in a larger population of subjects of known cerebral amyloidosis status is needed. Careful interpretation of plasma data is warranted.
Isolation and characterization of a minimal building block of polyubiquitin fibrils
Authors: Morimoto Daichi , Walinda Erik , Shinke Mayo , Sugase Kenji , Shirakawa Masahiro
Published: February 2018

As a posttranslational modifier, polyubiquitin is involved in the regulation of diverse intracellular processes; however, it is also found in pathological protein aggregates associated with Alzheimer’s disease and other neurodegenerative disorders. We previously observed that various types of polyubiquitin can form amyloid-like fibrils; however, the structural properties of these polyubiquitin fibrils have not been examined at an atomic level. Here we demonstrate that a soluble intermediate species can be extracted from disulfide-conjugated diubiquitin fibrils after cleaving the disulfide bonds in the fibrils. This newly discovered molecule is structurally and physicochemically distinguishable from native ubiquitin. In addition, it is thermodynamically metastable, as demonstrated by real-time NMR measurements. Collectively, our results suggest that the fibril-derived molecule is a minimal building block of polyubiquitin fibrils that reflects their structural and physicochemical properties.
Dietary supplementation with hybrid palm oil alters liver function in the common Marmoset
Authors: Spreafico Flavia , Sales Rafael Carvalho , Gil-Zamorano Judit , Medeiros Priscylla da Costa , Latasa Maria-Jesús , Lima Monique Ribeiro , de Souza Sergio Augusto Lopes , Martin-Hernández Roberto , Gómez-Coronado Diego , Iglesias-Gutierrez Eduardo , Mantilla-Escalante Diana C. , das Graças Tavares do Carmo Maria , Dávalos Alberto
Published: February 2018

Hybrid palm oil, which contains higher levels of oleic acid and lower saturated fatty acids in comparison with African palm oil, has been proposed to be somehow equivalent to extra virgin olive oil. However, the biological effects of its consumption are poorly described. Here we have explored the effects of its overconsumption on lipid metabolism in a non-human primate model, the common marmoset. Dietary supplementation of marmoset with hyperlipidic diet containing hybrid palm oil for 3 months did not modify plasma lipids levels, but increased glucose levels as compared to the supplementation with African palm oil. Liver volume was unexpectedly found to be more increased in marmosets consuming hybrid palm oil than in those consuming African palm oil. Hepatic total lipid content and circulating transaminases were dramatically increased in animals consuming hybrid palm oil, as well as an increased degree of fibrosis. Analysis of liver miRNAs showed a selective modulation of certain miRNAs by hybrid palm oil, some of which were predicted to target genes involved in cell adhesion molecules and peroxisomal pathways. Our data suggest that consumption of hybrid palm oil should be monitored carefully, as its overconsumption compared to that of African palm oil could involve important alterations to hepatic metabolism.
Verification of radiodynamic therapy by medical linear accelerator using a mouse melanoma tumor model
Authors: Takahashi Junko , Murakami Mami , Mori Takashi , Iwahashi Hitoshi
Published: February 2018

Combined treatment with 5-aminolevulinic acid (5-ALA) and X-rays improves tumor suppression in vivo. This is because the accumulated protoporphyrin IX from 5-ALA enhances the generation of ROS by the X-ray irradiation. In the present study, a high-energy medical linear accelerator was used instead of a non-medical low energy X-ray irradiator, which had been previously used. Tumor-bearing mice implanted with B16-BL6 melanoma cells were treated with fractionated doses of irradiation (in total, 20 or 30 Gy), using two types of X-ray irradiator after 5-ALA administration. Suppression of tumor growth was enhanced with X-ray irradiation in combination with 5-ALA treatment compared with X-ray treatment alone, using both medical and non-medical X-ray irradiators. 5-ALA has been used clinically for photodynamic therapy. Thus, “radiodynamic therapy”, using radiation from medical linacs as a physical driving force, rather than the light used in photodynamic therapy, may have potential clinical applications.
Quantitative modeling of microalgae based sequestration of atmospheric CO2
Authors: Hasan Mohammed F. , Vogt Frank
Published: February 2018

A novel modeling method is presented to quantify the sequestration of atmospheric CO2 by marine microalgae.
Simplified determination of complex stoichiometry for colorimetric metal indicators by inkjet printing
Authors: Kuwahara Kento , Yamada Kentaro , Suzuki Koji , Citterio Daniel
Published: February 2018

This paper presents the determination of complex binding stoichiometry for colorimetric metal indicators according to the Job plot method by means of an office inkjet printer in combination with digital colour analysis.
Electrochemical aptasensor based on aptamer-complimentary strand conjugate and thionine for sensitive detection of tetracycline with multi-walled carbon nanotubes and gold nanoparticles amplification
Authors: He Bao-Shan , Yan Sa-sa
Published: February 2018

Herein, a novel aptasensor with thionine as the electroactive probe was fabricated for the sensitive detection of tetracycline (TET).
Active droplet-array (ADA) microfluidics enables multiplexed complex bioassays for point of care testing
Authors: Shu Bowen , Li Zhujun , Yang Xiao , Xiao Feng , Lin Dongguo , Lei Xiuxia , Xu Banglao , Liu Dayu
Published: February 2018

Multiplexed complex bioassays are simply implemented via switching reagent-containing droplet arrays among alternative interaction zones in a programmable manner.
Ultrastable actinide endohedral borospherenes
Authors: Wang Cong-Zhi , Bo Tao , Lan Jian-Hui , Wu Qun-Yan , Chai Zhi-Fang , Gibson John K. , Shi Wei-Qun
Published: February 2018

DFT-PBE0 calculations on AnBn(An = U, Th;n= 36, 38, and 40) reveal the feasibility of actinide-doped borospherenes.
Flower-like Cu2NiSnS4microspheres for application as electrodes of asymmetric supercapacitors endowed with high energy density
Authors: Sarkar Samrat , Howli Promita , Ghorai Uttam Kumar , Das Biswajit , Samanta Madhupriya , Das Nirmalya Sankar , Chattopadhyay Kalyan Kumar
Published: February 2018

Asymmetric supercapacitors with superior specific capacitance and energy density are fabricated using Cu2NiSnS4, a novel and environmentally benign chalcogenide material.
Effects of isomorphic poly(butylene succinate-co-butylene fumarate) on the nucleation of poly(butylene succinate) and the formation of poly(butylene succinate) ring-banded spherulites
Authors: Zheng Yue , Tian Gengkun , Xue Jinxin , Zhou Jianjun , Huo Hong , Li Lin
Published: February 2018

The composition of isomorphic PBSF can dramatically affect the nucleation efficiency, the formation temperature of ring-banded spherulite and the band spacing of the PBS.
WO3-decorated ZnO nanostructures for light-activated applications
Authors: Gasparotto Alberto , Carraro Giorgio , Maccato Chiara , Sada Cinzia , Balbuena José , Cruz-Yusta Manuel , Sánchez Luis , Vodišek Nives , Lavrencic Štangar Urška , Barreca Davide
Published: February 2018

Calyx-like ZnO nanostructures decorated by WO3 nanoparticles are investigated for NOX degradation and self-cleaning end-uses.
The effect of different organic solvents on sodium ion storage in carbon nanopores
Authors: Karatrantos Argyrios , Khan Sharif , Ohba Tomonori , Cai Qiong
Published: February 2018

GCMC atomistic simulation to study the coupled effects of nanoporous hard carbon and different organic solvents on Na ion storage.
Support effects on adsorption and catalytic activation of O2 in single atom iron catalysts with graphene-based substrates
Authors: Gao Zheng-yang , Yang Wei-jie , Ding Xun-lei , Lv Gang , Yan Wei-ping
Published: February 2018

The adsorption and catalytic activation of O2 on single atom iron catalysts with graphene-based substrates were investigated systematically by density functional theory calculation.
Quantum corral effects on competing orders and electronic states in chiral d + id or f-wave superconductors
Authors: Zuo Xian-Jun
Published: February 2018

Self-consistent calculations are performed to characterize the quantum corral effects on the electronic states of chiral d + id or f-wave superconductors in this paper.
Towards flexible solid-state supercapacitors for smart and wearable electronics
Authors: Dubal Deepak P. , Chodankar Nilesh R. , Kim Do-Heyoung , Gomez-Romero Pedro
Published: February 2018

Flexible solid-state supercapacitors (FSSCs) are frontrunners in energy storage device technology and have attracted extensive attention owing to recent significant breakthroughs in modern wearable electronics.
Influence of fluorine on the synthesis of anatase TiO2 for photocatalytic partial oxidation: are exposed facets the main actors?
Authors: Bellardita Marianna , Garlisi Corrado , Venezia Anna Maria , Palmisano Giovanni , Palmisano Leonardo
Published: February 2018

The influence of fluorine on TiO2 exposed facets and on the physico-chemical properties was evaluated and a synergetic effect of the presence of fluorine and the facets' distribution was observed.
Steric control and the mechanism of benzaldehyde oxidation by polypyridyl oxoiron(iv) complexes: aromatic versus benzylic hydroxylation of aromatic aldehydes
Authors: Turcas Ramona , Lakk-Bogáth Dóra , Speier Gábor , Kaizer József
Published: February 2018

Stoichiometric oxidation of benzaldehyde to benzoic acid or salicylic acid by [FeIV(N4Py)(O)]2+ and [FeIV(asN4Py)(O)]2+ complexes has been carried out.
Bringing upconversion down to the molecular scale
Authors: Charbonnière Loïc J.
Published: February 2018

After bulk solids and nanoparticles, examples of upconversion are now emerging at the discrete molecular scale in solution.
Molecular characterization of PAHs based on land use analysis and multivariate source apportionment in multiple phases of the Yangtze estuary, China
Authors: Chen Xing , Liu Xinran , Liu Min , Yang Yi , Wu Shixue , Wang Chong
Published: February 2018

The coupling situation between PAHs, land uses and geographic conditions in multiple phases of densely populated estuarine and coastal areas was revealed.
FAMEs production from Scenedesmus obliquus in autotrophic, heterotrophic and mixotrophic cultures under different nitrogen conditions
Authors: Shen Xiao-Fei , Hu Hao , Ma Lin-Lin , Lam Paul K. S. , Yan Shao-Kai , Zhou Shou-Biao , Zeng Raymond Jianxiong
Published: February 2018

This study investigated the growth and biodiesel production of S. obliquus from autotrophic, heterotrophic and mixotrophic cultures under different nitrogen conditions.
Copper current collectors reduce long-term fouling of air cathodes in microbial fuel cells
Authors: Myung Jaewook , Yang Wulin , Saikaly Pascal E. , Logan Bruce E.
Published: February 2018

Long-term operation of wastewater-fed, microbial fuel cells (MFCs) with cathodes made of activated carbon and stainless steel (SS) current collectors can result in decreased performance due to cathode fouling.
Closed-loop feedback control for microfluidic systems through automated capacitive fluid height sensing
Authors: Soenksen L. R. , Kassis T. , Noh M. , Griffith L. G. , Trumper D. L.
Published: February 2018

Precise fluid height sensing in open-channel microfluidics has long been a desirable feature for a wide range of applications.
Light-responsive polymers for microfluidic applications
Authors: ter Schiphorst Jeroen , Saez Janire , Diamond Dermot , Benito-Lopez Fernando , Schenning Albertus P. H. J.
Published: February 2018

Light responsive polymers will drive revolutionary changes in microfluidics by reducing costs, platform dimensions and complexity.
Effect of structural manipulation in hetero-tri-aryl amine donor-based D–A′–π–A sensitizers in dye-sensitized solar cells
Authors: Patil Dinesh S. , Sonigara Keval K. , Jadhav Manoj M. , Avhad Kiran C. , Sharma Suryapratap , Soni Saurabh S. , Sekar Nagaiyan
Published: February 2018

Modification of a triarylamine donor group along with variation in the anchoring groups could finely manipulate the photophysical property and tuning the behaviour of D–A′–π–A sensitizers in DSSCs for better efficiency achievement.
First intramolecular Diels–Alder reactions using chromone derivatives: synthesis of chromeno[3,4-b]xanthones and 2-(benzo[c]chromenyl)chromones
Authors: Albuquerque Hélio M. T. , Santos Clementina M. M. , Cavaleiro José A. S. , Silva Artur M. S.
Published: February 2018

Chromeno[3,4-b]xanthones and 2-(benzo[c]chromenyl) chromones were obtainedviaan MW-assisted intramolecular DA reaction, followed byin situdehydrogenation.
In-silico design of nanoparticles for transdermal drug delivery application
Authors: Gupta Rakesh , Rai Beena
Published: February 2018

We present the use of computer simulation in designing nanoparticles for transdermal drug delivery application.
Early stage structural development of prototypical zeolitic imidazolate framework (ZIF) in solution
Authors: Terban Maxwell W. , Banerjee Debasis , Ghose Sanjit , Medasani Bharat , Shukla Anil , Legg Benjamin A. , Zhou Yufan , Zhu Zihua , Sushko Maria L. , De Yoreo James J. , Liu Jun , Thallapally Praveen K. , Billinge Simon J. L.
Published: February 2018

During synthesis, Zn2+ ions become coordinated by 2-methylimidazole to form secondary building units which function as building blocks to the final ZIF-8 framework.
A blue thermally activated delayed fluorescence emitter developed by appending a fluorene moiety to a carbazole donor with meta-linkage for high-efficiency OLEDs
Authors: Liang Jiao-Jiao , Li Yun , Yuan Yi , Li Si-Hua , Zhu Xiang-Dong , Barlow Stephen , Fung Man-Keung , Jiang Zuo-Quan , Marder Seth R. , Liao Liang-Sheng
Published: February 2018

A new TADF emitter was developed for blue OLEDs, and its thermal, photophysical and electrochemical properties were investigated.
Antifungal mechanism of cinnamaldehyde and citral combination against Penicillium expansum based on FT-IR fingerprint, plasma membrane, oxidative stress and volatile profile
Authors: Wang Yuan , Feng Kewei , Yang Haihua , Yuan Yahong , Yue Tianli
Published: February 2018

Cinnamaldehyde (Cin) and citral (Cit) have been studied as antimicrobial agents and natural preservatives, but their action modes are controversial, and the knowledge of their antifungal mechanism against P. expansum is still incomplete.
Investigation on enhanced photocatalytic degradation of bisphenol A with bismuth oxyiodide catalyst using response surface methodology
Authors: Zhang Dan , Wang Fei , Cao Suzhen , Duan Xiaoli
Published: February 2018

Bi7O9I3 was synthesized via a microwave irradiation method and the influence of different parameters on BPA degradation was investigated using a response surface methodology.
Efficient photocatalysis with graphene oxide/Ag/Ag2S–TiO2 nanocomposites under visible light irradiation
Authors: Shuang Shuang , Lv Ruitao , Cui Xiaoyang , Xie Zheng , Zheng Jian , Zhang Zhengjun
Published: February 2018

The photocatalytic reaction efficiency of GO/Ag/Ag2S–TiO2 nanorod arrays is 600% higher than that of a pure TiO2 sample under visible light.
Mass and charge distributions of amyloid fibers involved in neurodegenerative diseases: mapping heterogeneity and polymorphism
Authors: Pansieri Jonathan , Halim Mohammad A. , Vendrely Charlotte , Dumoulin Mireille , Legrand François , Sallanon Marcelle Moulin , Chierici Sabine , Denti Simona , Dagany Xavier , Dugourd Philippe , Marquette Christel , Antoine Rodolphe , Forge Vincent
Published: February 2018

Characterization by charge detection mass spectrometry of amyloid fibers involved in neurodegenerative diseases: Aβ peptide, tau and α-synuclein.
Two-photon fluorescent polysiloxane-based films with thermally responsive self switching properties achieved by a unique reversible spirocyclization mechanism
Authors: Zuo Yujing , Yang Tingxin , Zhang Yu , Gou Zhiming , Tian Minggang , Kong Xiuqi , Lin Weiying
Published: February 2018

The first example of a two-photon fluorescent polysiloxane-based film with fantastic thermal-responsive properties was reported. A unique alkaline tuned reversible spirocyclization mechanism was proposed.
Structure and formation of highly luminescent protein-stabilized gold clusters
Authors: Chevrier D. M. , Thanthirige V. D. , Luo Z. , Driscoll S. , Cho P. , MacDonald M. A. , Yao Q. , Guda R. , Xie J. , Johnson E. R. , Chatt A. , Zheng N. , Zhang P.
Published: February 2018

Findings on the structure and formation of luminescent protein-stabilized gold clusters reveal interlocked gold-thiolate rings and a unique bio-assembled pathway.
Imaging and evaluation of sulfane sulfur in acute brain ischemia using a mitochondria-targeted near-infrared fluorescent probe
Authors: Gao Min , Wang Rui , Yu Fabiao , You Jinmao , Chen Lingxin
Published: February 2018

Imaging and evaluation of sulfane sulfur in acute brain ischemia using a mitochondria-targeted near-infrared fluorescent probe
High-performance flexible oxide TFTs: optimization of a-IGZO film by modulating the voltage waveform of pulse DC magnetron sputtering without post treatment
Authors: Yao Rihui , Zheng Zeke , Fang Zhiqiang , Zhang Hongke , Zhang Xiaochen , Ning Honglong , Wang Lei , Peng Junbiao , Xie Weiguang , Lu Xubing
Published: February 2018

We propose a facile approach to fabricate high-performance flexible a-IGZO TFTs by adopting the waveform modulation of pulse DC magnetron sputtering.
Excellent high temperature field emission behavior with an ultra-low turn-on field and reliable current emission stability from SiC@SiO2@graphene nanoarray emitters
Authors: Li Z. J. , Zhao J. , Zhang M. , Wang Y. Q. , Ding S. Q. , Song G. Y. , Meng A. L. , Li Q. D.
Published: February 2018

SiC@SiO2@graphene nanoarrays with numerous flake-like graphene coatings have been prepared on a Si substrate through a simple chemical vapor deposition (CVD) approach.
Porous organic/inorganic hybrid one-dimensional photonic crystals for rapid visual detection of organic solvents
Authors: Kou Donghui , Zhang Shufen , Lutkenhaus Jodie L. , Wang Lin , Tang Bingtao , Ma Wei
Published: February 2018

A highly sensitive 1DPC sensor for rapid visual detection of organic solvents was achieved.
Tailoring the self-assembling abilities of functional hybrid nanomaterials: from rod-like to disk-like clustomesogens based on a luminescent {Mo6Br8}4+inorganic cluster core
Authors: Gandubert Aurore , Amela-Cortes Maria , Nayak Susanta Kumar , Vicent Cristian , Mériadec Cristelle , Artzner Franck , Cordier Stéphane , Molard Yann
Published: February 2018

Self-assembling abilities of hybrid materials are controlled by modifying the ligand density around an emissive bulky metallic cluster core.
Fabrication of a self-assembled and flexible SERS nanosensor for explosive detection at parts-per-quadrillion levels from fingerprints
Authors: Liyanage Thakshila , Rael Ashur , Shaffer Sidney , Zaidi Shozaf , Goodpaster John V. , Sardar Rajesh
Published: February 2018

A self-assembled and flexible nanosensor was developed for ultrasensitive detection of explosives from latent fingerprints.
Correction: C–H and H–H activation at a di-titanium centre
Authors: Tsoureas Nikolaos , Green Jennifer C. , Cloke F. Geoffrey N.
Published: February 2018

Correction for ‘C–H and H–H activation at a di-titanium centre’ by Nikolaos Tsoureas et al., Chem. Commun., 2017, 53, 13117–13120.
Expanding the allyl analogy: accessing η3-P,B,P diphosphinoborane complexes of group 10
Authors: Drover Marcus W. , Peters Jonas C.
Published: February 2018

Using the diphosphinoborane, (PPh2)2BMes (Mes = 2,4,6-Me3C6H3), we report the first examples of η3-P,B,P-ligated complexes using Ni(0) and Pt(ii).
Highly efficient direct oxygen electro-reduction by partially unfolded laccases immobilized on waste-derived magnetically separable nanoparticles
Authors: Rodríguez-Padrón Daily , Puente-Santiago Alain R. , Caballero Alvaro , Balu Alina M. , Romero Antonio A. , Luque Rafael
Published: February 2018

A biocatalytic system based on laccase functionalized waste-derived iron oxide nanoparticles (LAC-DA-Fe2O3) was designed by a mechanochemical approach and employed in the electrocatalytic reduction of oxygen.
Expansion of the (BB)Ru metallacycle with coinage metal cations: formation of B–M–Ru–B (M = Cu, Ag, Au) dimetalacyclodiboryls
Authors: Eleazer Bennett J. , Smith Mark D. , Popov Alexey A. , Peryshkov Dmitry V.
Published: February 2018

Assembly of bimetallic complexes on boron clusters by coordination of coinage metal cations to Ru–B single bonds.
A new multicomponent CDs/Ag@Mg–Al–Ce-LDH nanocatalyst for highly efficient degradation of organic water pollutants
Authors: Iqbal Kanwal , Iqbal Anam , Kirillov Alexander M. , Shan Changfu , Liu Weisheng , Tang Yu
Published: February 2018

A novel type of multicomponent and recyclable nanocatalyst CDs/Ag@Mg–Al–Ce-LDH was successfully assembled by functionalizing a magnesium–aluminum layered double hydroxide support doped with Ce (denoted as Mg–Al–Ce-LDH) with carbon dots (CDs) and Ag nanoparticles.
Superoscillations in solar MHD waves and their possible role in heating coronal loops
Authors: López Ariste A. , Facchin M.
Published: February 2018

Aims. We aim to study the presence of superoscillations in coronal magnetoacoustic (MHD) waves and their possible role in heating coronal loops through the strong and localised gradients that they generate on the wave.

Methods. An analytic model is built for the transition between sausage and kink wave modes propagating along field lines in the corona. We compute in this model the local frequencies, the wave gradients, and the associated heating rates due to compressive viscosity.

Results. We find superoscillations associated with the transition between wave modes accompanying the wave dislocation that shifts through the wave domain. Frequencies ten times higher than the normal frequency are found. This means that a typical three-minute coronal wave will oscillate locally in 10 to 20 s. Such high frequencies bring up strong gradients that efficiently dissipate the wave through compressive viscosity. We compute the associated heating rates; locally, they are very strong, largely compensating typical radiative losses.

Conclusions. We find a new heating mechanism associated to magnetoacoustic waves in the corona. Heating due to superoscillations only happens along particular field lines with small cross sections, comparable in size to coronal loops, inside the much larger magnetic flux tubes and wave propagation domain.
New measurements of D/H on Mars using EXES aboard SOFIA
Authors: Encrenaz T. , DeWitt C. , Richter M. J. , Greathouse T. K. , Fouchet T. , Montmessin F. , Lefèvre F. , Bézard B. , Atreya S. K. , Aoki S. , Sagawa H.
Published: February 2018

The global D/H ratio on Mars is an important measurement for understanding the past history of water on Mars; locally, through condensation and sublimation processes, it is a possible tracer of the sources and sinks of water vapor on Mars. Measuring D/H as a function of longitude, latitude and season is necessary for determining the present averaged value of D/H on Mars. Following an earlier measurement in April 2014, we used the Echelon Cross Echelle Spectrograph (EXES) instrument on board the Stratospheric Observatory for Infrared Astronomy (SOFIA) facility to map D/H on Mars on two occasions, on March 24, 2016 (Ls = 127°), and January 24, 2017 (Ls = 304°), by measuring simultaneously the abundances of H2O and HDO in the 1383–1391 cm−1 range (7.2 μm). The D/H disk-integrated values are 4.0 (+0.8, −0.6) × Vienna Standard Mean Ocean Water (VSMOW) and 4.5 (+0.7, −0.6) × VSMOW, respectively, in agreement with our earlier result. The main result of this study is that there is no evidence of strong local variations in the D/H ratio nor for seasonal variations in the global D/H ratio between northern summer and southern summer.
Strong Lagrange duality and the maximum principle for nonlinear discrete time optimal control problems
Authors: Tamminen Eero V.
Published: February 2018

We examine discrete-time optimal control problems with general, possibly non-linear or non-smooth dynamic equations, and state-control inequality and equality constraints. A new generalized convexity condition for the dynamics and constraints is defined, and it is proved that this property, together with a constraint qualification constitute sufficient conditions for the strong Lagrange duality result and saddle-point optimality conditions for the problem. The discrete maximum principle of Pontryagin is obtained in a straightforward manner from the strong Lagrange duality theorem, first in a new form in which the Lagrangian is minimized both with respect to the state and to the control variables. Assuming differentiability, the maximum principle is obtained in the usual form. It is shown that dynamic systems satisfying a global controllability condition with convex costs, have the required convexity property. This controllability condition is a natural extension of the customary directional convexity condition applied in the derivation of the discrete maximum principle for local optima in the literature.
Conformity and statistical tolerancing
Authors: Leblond Laurent , Pillet Maurice
Published: February 2018

Statistical tolerancing was first proposed by Shewhart (Economic Control of Quality of Manufactured Product, (1931) reprinted 1980 by ASQC), in spite of this long history, its use remains moderate. One of the probable reasons for this low utilization is undoubtedly the difficulty for designers to anticipate the risks of this approach. The arithmetic tolerance (worst case) allows a simple interpretation: conformity is defined by the presence of the characteristic in an interval. Statistical tolerancing is more complex in its definition. An interval is not sufficient to define the conformance. To justify the statistical tolerancing formula used by designers, a tolerance interval should be interpreted as the interval where most of the parts produced should probably be located. This tolerance is justified by considering a conformity criterion of the parts guaranteeing low offsets on the latter characteristics. Unlike traditional arithmetic tolerancing, statistical tolerancing requires a sustained exchange of information between design and manufacture to be used safely. This paper proposes a formal definition of the conformity, which we apply successively to the quadratic and arithmetic tolerancing. We introduce a concept of concavity, which helps us to demonstrate the link between tolerancing approach and conformity. We use this concept to demonstrate the various acceptable propositions of statistical tolerancing (in the space decentring, dispersion).
Evaluation of brake parameters in copper discs of various thicknesses and speeds using Neodymium – Iron – Boron Magnets
Authors: Anantha Krishna G. L. , Sathish Kumar K. M.
Published: February 2018

Neodymium – Iron – Boron (NdFeB) permanent magnets of 12.5 mm thickness and 50 mm diameter are chosen for analyses because of their higher remanence and coercivity. Experimental analyses were carried out with Copper discs of thickness 4 mm, 6 mm and 8 mm at 2000 rpm, 3000 rpm, 4000 rpm and 5000 rpm. Experiments were conducted with three different positions of magnets such as 2 coaxial magnets, single magnet and single magnet with sudden application conditions. The brake parameters recorded are % speed reduction, deceleration and time taken. In 2 coaxial magnets condition, brake parameters are better in 6 mm thick disc. In single magnet condition, the brake parameters in 6 mm thick disc are found to be more consistent than 4 mm and 8 mm thick discs. In single magnet with sudden application condition, in 4 mm thick disc, the brake parameters are found better. During analysis, very high repulsion was experienced by magnet with 8 mm thick Copper disc at all the above mentioned speeds in single magnet with sudden application condition. For high speed train applications, single magnet condition with 6mm thick disc may be suitable. For high speed automotive applications, single magnet with sudden application condition with 4 mm thick disc may be suitable.
Analysis of various parameters affecting weir design and fabrication of Weirs: An Overview
Authors: Vanishree B. Rao , Manjula R.
Published: February 2018

Several geometric parameters influence weir discharge and it is explained in our present study. The PK weir is more efficient than rectangular labyrinth weir due to reduction in entrance losses of PK weir inlet key geometry. PK weir is a type of labyrinth weir with variation in angle. Therefore, in this paper we also discuss about labyrinth weir. PKW are compatible for constructing on existing or new spillway with lesser space requirement and structural stability. PKW are installed in order to increase the discharge capacity for a given footprint area. PKW is used to increase the overflow capacity of existing dams such as, Hazelmare dam (South Africa), Dartmouth dam (Australia). Trapezoidal piano key weirs have higher discharge efficiency than rectangular weirs and it is due to interference wedge. Cd of TPKW is influenced by L/W but Wi/Wo has least effect.
Experimental investigation of torsional vibration isolation using Magneto Rheological Elastomer
Authors: Praveen Shenoy K , Singh Abhishek Kumar , Sai Aditya Raman K , Gangadharan K. V.
Published: February 2018

Rotating systems suffer from lateral and torsional vibrations which have detrimental effect on the roto-dynamic performance. Many available technologies such as vibration isolators and vibration absorbers deal with the torsional vibrations to a certain extent, however passive isolators and absorbers find less application when the input conditions are dynamic. The present work discusses use of a smart material called as Magneto Rheological Elastomer (MRE), whose properties can be changed based on magnetic field input, as a potential isolator for torsional vibrations under dynamic loading conditions. Carbonyl Iron Particles (CIP) of average size 5 μm were mixed with RTV Silicone rubber to form the MRE. The effect of magnetic field on the system parameters was comprehended under impulse loading conditions using a custom built in-house system. Series arrangement of accelerometers were used to differentiate between the torsional and the bending modes of vibration of the system. Impact hammer tests were carried out on the torsional system to study its response, in the presence and absence of magnetic field. The tests revealed a shift in torsional frequency in the presence of magnetic field which elucidates the ability of MRE to work as a potential vibration isolator for torsional systems.
Solid Modelling Interaction with Sensors for Virtual Reality Welding
Authors: Bharath V. G. , Patil Rajashekar
Published: February 2018

The imperative part of strong displaying in virtual reality framework is to improve the movement of a user with definitive movement control in genuine intelligent condition. In a real environment motion characteristic is based on sensors and servomechanisms where as in virtual reality systems the motion fundamentals are kinematic in nature. To achieve physically correct interactivity suitable dynamic constraints, should be imposed which can be obtained by augmented reality interface. Beyond input and output hardware, the underlying software plays a very important role in virtual reality systems. It is responsible for the managing of input/output devices, analysing incoming data and generating proper feedback. This research paper focusses on movement displaying for connection between CAD models and Virtual Reality Models using 3ds Max 2017 and Unity 3d softwares. The paper portrays different equipment arrangement of sensors and Arduino for virtual reality welding.
Modified bug-1 algorithm based strategy for obstacle avoidance in multi robot system
Authors: Kandathil Jom J. , Mathew Robins , Hiremath Somashekhar S.
Published: February 2018

One of the primary ability of an intelligent mobile robot system is obstacle avoidance. BUG algorithms are classic examples of the algorithms used for achieving obstacle avoidance. Unlike many other planning algorithms based on global knowledge, BUG algorithms assume only local knowledge of the environment and a global goal. Among the variations of the BUG algorithms that prevail, BUG-0, BUG-1 and BUG-2 are the more prominent versions. The exhaustive search algorithm present in BUG-1 makes it more reliable and safer for practical applications. Overall, this provides a more predictable and dependable performance. Hence, the essential focus in this paper is on implementing the BUG-1 algorithm across a group of robots to move them from a start location to a target location. The results are compared with the results from BUG-1 algorithm implemented on a single robot. The strategy developed in this work reduces the time involved in moving the robots from starting location to the target location. Further, the paper shows that the total distance covered by each robot in a multi robot-system is always lesser than or equal to that travelled by a single robot executing the same problem.
Design and Analysis of Split Fixture for Gear Hobbing Machine
Authors: Shenoy Prajwal , Nithesh Naik , Shettar Manjunath , Debarghya  , Abbas Wasim
Published: February 2018

Compared to the conventional gear hobbing fixtures, split fixture can effectively reduce job set-up time during the manufacturing process. This paper investigates the behaviour and analysis of split fixture under varying static loading conditions. Design of the part was established by considering the ability of the split fixture to carry jobs of various diameters. In order to validate the design, Static structural analysis was carried out on two positional configurations of the split fixture. A load of 1 ton was applied on the resting face of the fixture to simulate the effect of holding the job. The analysis included a study of the Stress, Deformations, and Modal analysis at different resonating frequencies to check for failure of design. By applying varying loads similar to practical conditions, it was observed that the design successfully withstood the applied forces without failure and a factor of safety of 142 was achieved in a critical loading case. Investigating the effect of dynamic loads on the Split Fixture and including auxiliary assembly components in design analysis.
Rational designing of the internal water supply system in reconstructed residential buildings of mass standard series
Authors: Orlov Evgeny
Published: February 2018

The issues of water supply system reconstruction in mass series buildings are reviewed with consideration of water- and resource saving. Principal points for location of plumbing cells in apartments, arrangement of water devices and wastewater receivers, selection of pipelines for reconstructed water line are described. Comparative analysis of design variants of inner water line before and following reconstruction are given. It was found that applying the developed system design approaches the head losses in the inner water supply line will be significantly decreased as well as the water mains length will be decreased with material and installation saving. Based on the data the conclusions on necessity to review standard arrangement solutions of water supply systems in the reconstructed buildings were made. Recommendations on water loss reduction in the system by installation of special water saving fittings on water devices and touchless faucets.
Automated software for hydraulic simulation of pipeline operation
Authors: Hurgin Roman
Published: February 2018

Design of modern water supply systems of large cities as well as their management via renovation of hydraulic models poses time-consuming tasks to researchers, and coping with this task requires specific approaches. When tackling these tasks, water services companies come across a lot of information about various objects of water infrastructure, the majority of which is located underground. In those cases, modern computer-aided design systems containing various components come to help. These systems help to solve a wide array of problems using existing information regarding pipelines, analysis and optimization of their basic parameters. CAD software is becoming an integral part of water supply systems management in large cities, and its capabilities allow engineering and operating companies to not only collect all the necessary data concerning water supply systems in any given city, but also to conduct research aimed at improving various parameters of these systems, including optimization of their hydraulic properties which directly determine the quality of water. This paper contains the analysis of automated CAD software for hydraulic design and management of city water supply systems in order to provide safe and efficient operation of these water supply systems. Authors select the most suitable software that might be used to provide hydraulic compatibility of old and new sections of water supply ring mains after selective or continuous draw-in renovation and decrease in diameter of distribution networks against the background of water consumption decrease in the cities.