ANALYSIS OF THE ACTIVITY OF TOXOPLASMA INFECTION ON IN ELDERLY AND OLD PEOPLE
Authors:   FSBI National Research Center for Epidemiology and Microbiology named after N.N. honorary academician N.F. Gamaleya” of the Ministry of Health of Russia, Moscow, Russia, Goncharov D.B. , Abbazova E.V. ,   FSBI National Research Center for Epidemiology and Microbiology named after N.N. honorary academician N.F. Gamaleya” of the Ministry of Health of Russia, Moscow, Russia, Zorkina Y.A. ,   GBUZ "Psychiatric Clinical Hospital No. 1 named after. ON THE. Alekseev of the Department of Health of Moscow, Moscow, Russia,   Federal State Budgetary Institution "National Medical Research Center for Psychiatry and Narcology named after N.N. V.P. Serbian” of the Ministry of Health of the Russian Federation, Moscow, Russia, Romanov D.V. ,   Federal State Budgetary Scientific Institution "Scientific Center for Mental Health" RAS, Moscow, Russia, Andreyuk D.S. ,   GBUZ "Psychiatric Clinical Hospital No. 1 named after. ON THE. Alekseev of the Department of Health of Moscow, Moscow, Russia, Stepanova Е.V. ,   Institute of Medical Parasitology, Tropical and Vector-borne Diseases Marcinovsky First Moscow State Medical University. THEM. Sechenov, Moscow, Russia, Baranets М.S. ,   FSBI National Research Center for Epidemiology and Microbiology named after N.N. honorary academician N.F. Gamaleya” of the Ministry of Health of Russia, Moscow, Russia, Kostyuk G.P. ,   GBUZ "Psychiatric Clinical Hospital No. 1 named after. ON THE. Alekseev of the Department of Health of Moscow, Moscow, Russia, Morozova А.Yu. ,   GBUZ "Psychiatric Clinical Hospital No. 1 named after. ON THE. Alekseev of the Department of Health of Moscow, Moscow, Russia,   Federal State Budgetary Institution "National Medical Research Center for Psychiatry and Narcology named after N.N. V.P. Serbian” of the Ministry of Health of the Russian Federation, Moscow, Russia, Abramova О.V. ,   GBUZ "Psychiatric Clinical Hospital No. 1 named after. ON THE. Alekseev of the Department of Health of Moscow, Moscow, Russia,   Federal State Budgetary Institution "National Medical Research Center for Psychiatry and Narcology named after N.N. V.P. Serbian” of the Ministry of Health of the Russian Federation, Moscow, Russia, Kurmyshev М.V. ,   GBUZ "Psychiatric Clinical Hospital No. 1 named after. ON THE. Alekseev of the Department of Health of Moscow, Moscow, Russia, Savilov V.B. ,   GBUZ "Psychiatric Clinical Hospital No. 1 named after. ON THE. Alekseev of the Department of Health of Moscow, Moscow, Russia, Andriushchenko А.V. ,   GBUZ "Psychiatric Clinical Hospital No. 1 named after. ON THE. Alekseev of the Department of Health of Moscow, Moscow, Russia, Karpenko О.А. ,   GBUZ "Psychiatric Clinical Hospital No. 1 named after. ON THE. Alekseev of the Department of Health of Moscow, Moscow, Russia, Gabrielyan N.I. ,   FGBU "National Medical Research Center for Transplantology and Artificial Organs named after Academician V.I. Shumakov, Moscow, Russia
Published: June 2023

Introduction. Persons of the older age group, due to weakened immunity, are at risk for toxoplasmosis: with age, the level of seropositivity and the risk of reactivation of infection in people with chronic infection increases. But in clinical and epidemiological terms, this group has not been sufficiently studied. Purpose of the study. Determination of the level of seropositivity and the degree of activity of toxoplasma invasion in persons of the older age category without pathology, as well as in combination with psychoneurological symptoms or transplantation of solid organs. Materials and methods. The ELISA method was used to determine various classes of antibodies to T. gondii in the blood sera of 614 people aged 60 to 93 years (conditionally healthy individuals, patients with neuropsychiatric pathology, with cognitive decline, after organ transplantation). Results. IgG antibodies to T. gondii were detected in 51,5 % of the examined people. There was a trend of increasing infection from the age of 60-64 years to 75-79 years. Very few cases of acute toxoplasmosis have been identified; more significant was the detection of IgA antibodies, a reactivation marker, in 10,1 % of the examined antibodies. The largest number of individuals with IgA was observed in patients after transplantation, with neuropsychiatric pathology and cognitive decline. Discussion. Since toxoplasmosis is a latent infection of the brain and its association with a number of mental and neurodegenerative diseases has been proven, the high T. gondii infection in elderly people and the presence of reactivation markers in them suggests systematic monitoring of invasion, especially when combined with CNS pathology and reduced immunity. People aged "60+" with a certain clinical history are at risk in the presence of a parasite in the body. Conclusion. Finding an association between toxoplasmosis and psychiatric disorders in immunocompetent individuals is the basis for further monitoring of such associations with a view to their prevention and treatment. Key words: toxoplasmosis, Toxoplasma gondii, psycho-neurological diseases, elderly people, detection of antibodies.