bluuebunny/crossref_metadata_2025 huggingface dataset:
La mort parentale au travers de la littérature jeunesse
Authors: MAUROY Anthony , LARDINOIS Noémie , DELANNOY Pauline , GAUGUE Justine
Published: September 2022

En explorant les représentations de la mort d’un parent au sein des albums de littérature jeunesse, cette recherche se propose d'investiguer la cohérence entre ces représentations et la compréhension du concept de mort chez l'enfant. Comment aborder ce sujet considéré comme tabou avec un enfant ? Quelles sont les appuis sur lesquels un adulte a la possibilité de se reposer afin d'initier un échange avec l'enfant ? Les albums de littérature jeunesse semblent être une piste intéressante pour répondre à ces questions. Cette étude présente l’analyse d'un corpus composé de 30 albums de littérature jeunesse traitant du décès parental et destinés à des enfants à partir de trois ans. L’usage d’une grille de lecture construite pour la recherche permet de mettre en avant des éléments de mise en forme et de mise en sens et de là, des pistes d'investigation concernant l'accompagnement du deuil chez l'enfant.
L'anxiété et la dépression liées à la fin de vie soulagées par psychothérapie assistée de psychédéliques
Authors: CARRIGAN Kali , FRANÇOIS Maxime , DUBUS Zoë , FAUVEL Baptiste
Published: September 2022

La personne confrontée à la mort peut avoir des besoins psychologiques et spirituels qui nécessitent une prise en charge globale. Actuellement, les psychothérapies et pharmacothérapies proposées en soins palliatifs montrent seulement des effets faibles à modérés sur la qualité de vie, l’anxiété et la dépression des patients. Cet article expose comment la réintroduction d’une prise en charge alternative, la psychothérapie assistée par psychédéliques, pourrait permettre aux patients à la fois de mieux accepter l’idée de la mort et de se sentir plus satisfaits envers la vie en général. Nous présentons les résultats des essais cliniques menés jusqu’à aujourd’hui et détaillons quels phénomènes psychologiques pourraient être à l’origine des effets psychothérapeutiques de l’expérience psychédélique. Les propos sont illustrés par le témoignage d’un patient atteint de cancer ayant vécu une expérience psychédélique en milieu naturel avec de l’acide lysergique diéthylamide. La manière dont est administrée la psychothérapie assistée par psychédéliques et ses spécificités par rapport aux traitements classiques sont également abordées. Nous concluons en proposant que la réintroduction des psychothérapies assistées par psychédéliques en soins palliatifs, en plus d’améliorer la prise en charge des patients, pourrait faire évoluer le rapport à la mort dans la société.
The Democratic Scaffold and the Economic Axe. Review of the book: Stefan Collini. What Are Universities For?
Authors: Lyubzhin Alexey
Published: September 2022

A detailed analysis of the author’s judgments on the key issues covered in the book — the functions of contemporary university, cooperation and competition, the “egregious audit culture”, the nature and meaning of the humanities, assessment of humanities research quality, the impact factor, and university financing — has shown that many situations actually describe the existing education system in Russia.
On Children and the Teaching Profession — with Love. Foreword to the Russian Publication of Vivian Paley "The Boy Who Would Be a Helicopter"
Authors: Filonovich Sergey
Published: September 2022

Foreword to the Russian Publication of Vivian Paley "The Boy Who Would Be a Helicopter" by Sergey Filonovich.
Development of Green Differential Pulse Voltammetric Strategy for the Determination of Alfuzosin Hydrochloride at Pencil Graphite and Modified Carbon Paste Electrodes
Authors: Metias Youstina Mekhail , Hussien Emad Mohamed , Hosny Mervat Mohamed , Ayad Magda Mohamed
Published: September 2022

A sensitive and inexpensive differential pulse voltammetric technique was applied to investigate the electrochemical behavior of alfuzosin hydrochloride at two different working electrodes: silica gel modified carbon paste and pencil graphite electrodes (PGE). The voltammetric conditions were optimized using cyclic voltammetry, showing an irreversible anodic peak in Britton-Robinson buffered medium (pH 6) at 0.86–0.90 V. The electrochemical responses were linearly correlated with alfuzosin concentrations (R2 > 0.999) in the ranges of 0.6–20 and 0.3–20 μM, exhibiting higher electrocatalytic activity at PGE with a low detection limit/ detectability of 0.099 μM. In addition, this study was a successful attempt for the drug determination in tablets and spiked urine samples with green profile evaluation, employing the National Environmental Methods Index, analytical Eco-Scale score, and Green Analytical Procedure Index.
Carvacrol Derivatives as Antifungal Agents: Synthesis, Antimicrobial Activity and in Silico Studies on Carvacryl Esters
Authors: Lazarević Jelena , Marković Ana , Šmelcerović Andrija , Stojanović Gordana , Ciuffreda Pierangela , Santaniello Enzo
Published: September 2022

Chemical modifications of natural monoterpenoids to various derivatives have been reported to result in enhancement of biological activities when compared to parent compounds. In this context a well-known biocide and food additive, carvacrol, served as a basic scaffold onto which a phenolic functionality transformation by introducing acyl groups was performed. By using this simple methodology, we obtained a small series of 25 esters. For each of the obtained compounds we have performed structural characterization, in vitro antimicrobial testing and in silico calculation of physico-chemical, pharmacokinetic and toxicological properties. Despite numerous data on the synthesis and bioactivity of carvacryl ester lower homologues, there are scarce data on esters with acid components higher than C9, so that among 25 compounds, 10 were reported for the first time (spectral characterization for 12 are herein the first reported). Our research is also the first comprehensive study of carvacryl esters antifungal and of medium/long chain fatty acid esters antibacterial activities. Interesting result is that all the synthesized esters, regardless the nature of the R residue, have shown activity on fungal strain Aspergilus niger and on yeast Candida albicans comparable to carvacrol. Besides presented experimental data, implementation of in silico calculation of physico-chemical, pharmacokinetic and toxicological properties on the prepared compounds, may be valuable information in further research.
N-(9,10-Dioxo-9,10-dihydroanthracen-1(2)-yl)-2-(R-thio) Acetamides: Synthesis, Antioxidant and Antiplatelet Activity
Authors: Stasevych Maryna , Zvarych Viktor , Yaremkevych Olena , Vovk Mykhaylo , Vaskevych Alla , Halenova Tetiana , Savchuk Olexii
Published: September 2022

The synthesis of new N-(9,10-dioxo-9,10-dihydroanthracen-1(2)-yl)-2-(R-thio) acetamides was carried out using reaction of 2-chloro-N-(9,10-dioxo-9,10-dihydroanthracene-1(2)-yl)acetamides with functionalized thiols in the presence of potassium carbonate in N,N-dimethylformamide (DMF) at room temperature. Evaluation of the synthesized compounds on such indicators of radical scavenging activity as lipid peroxidation (LP) and oxidative modification of proteins (OMP) in vitro in rat liver homogenate was carried out. It was determined that the compounds with a substituent in the first position of anthracedione core showed better antioxidant properties than their isomers with a substituent in the second position. The compounds 6 and 7 with the best indicators of radical-scavenging activity were determined. Antioxidant effect in OMP processes was also determined for compound 10. The antiplatelet activity study in vitro revealed compound 10 with the inhibited effect of ADP-induced aggregation.
A New Zn(II) Two-dimensional Coordination Polymer: Synthesis, Structure, Highly Efficient Fluorescence and DFT Study
Authors: Li Fen-Fang
Published: September 2022

A new two-dimensional coordinate polymer, {[Zn2(pbmpd)(H2O)4]·(H2O)}n (H4pbmpd = 1,1’-(1,4-phenylenebis(methylene)) bis-(1H-pyrazole-3,5-dicarboxylic acid)), has been hydrothermally synthesized and characterized by IR spectrum, elemental analysis, TGA and X-ray single-crystal/powder diffraction. Structural analyses reveal that complex 1 exhibits a two-dimensional sheet structure in the crystal lattice. In complex 1, the carboxylic oxygen atoms and conjugated N atoms of pbmpd4– bridge zinc(II) ions form indefinitely zigzag shaped one-dimensional chains through π···π stacking interactions which are further connected by [ZnO6] units to form a novel two-dimensional structure. Finally, π···π stacking interactions and intermolecular hydrogen bonds assemble the two dimensional networks into a three-dimensional framework. Furthermore, the luminescent properties are also discussed. Interestingly, the solid state photoluminescence properties of the title polymer show the enhancement effect of spectrum. Density functional theory (DFT) calculations were used to support the experimental data.
Synthesis, Antimicrobial and Molecular Docking Studies of Some New Derivatives of 2,3-Dihydroquinazolin-4(1H)-one
Authors: Zahmatkesh Karim , Dilmaghani Karim Akbari , Sarveahrabi Yasin
Published: September 2022

In the present study a series of novel 2-(substituted phenyl)-3-(5-phenyl-1,3,4-thiadiazol-2-yl)-2,3-dihydroquinazolin-4(1H)-one derivatives were synthesized by refluxing isatoic anhydride, 5-phenyl-1,3,4-thiadiazol-2-amine and aromatic aldehydes in the presence of p-TsOH as the catalyst and in H2O as the solvent and characterized by spectroscopic data and analytical methods. Antibacterial and antifungal activity of the title compounds were evaluated against two Gram positive and two Gram negative bacterial strains and strains of fungi and compared with ·standard drugs, using well diffusion method minimum bactericidal/fungicidal concentration were determined. The potential α-amylase and α-glucosidase inhibitory activity of compounds 4a–l were investigated in silico using molecular docking simulation method. Therefore, these 2,3-dihydroquinazolin-4(1H)-one derivatives may be considered as promising candidates for the development of new classes of antimicrobial and antidiabetic drugs.
Electronic Structures and Reactivities of COVID-19 Drugs: A DFT Study
Authors: Aydogdu Seyda , Hatipoglu Arzu
Published: September 2022

These days, the world is facing the threat of pandemic Coronavirus Disease 2019 (COVID-19). Although a vaccine has been found to combat the pandemic, it is essential to find drugs for an effective treatment method against this disease as soon as possible. In this study, electronic and thermodynamic properties, molecular electrostatic potential (MEP) analysis, and frontier molecular orbitals (FMOs) of nine different covid drugs were studied with Density Functional Theory (DFT). In addition, the relationship between the electronic structures of these drugs and their biological effectiveness was examined. All parameters were computed at the B3LYP/6-311++g(d,p) level. The Solvent effect was evaluated using conductor-like polarizable continuum model (CPCM) as the solvation model. It was observed that electrophilic indexes were important to understand the efficiencies of these drugs in COVID-19 disease. Paxlovid, hydroxyquinone, and nitazoxanide were found as the most thermodynamically stable molecules. Thermodynamic parameters also demonstrated that these drugs were more stable in the aqueous media. Global descriptors and the reactivity of these drugs were found to be related. Nitazoxanide molecule exhibited the highest dipole moment. The high dipole moments of drugs can cause hydrophilic interactions that increase their effectiveness in an aqueous solution.
Industrial Wastewater as a Source of External Organic Carbon for the Biological Nutrient Removal
Authors: Kožárová Bibiána , Zakhar Ronald , Imreová Zuzana , Hanuljaková Hana , Karlovská Ines , Drtil Miloslav
Published: September 2022

Addition of external organic carbon source for denitrification is generally used in wastewater treatment plants (WWTPs) to intensify nitrogen removal processes. The aim of the laboratory survey was to measure the composition of concentrated industrial wastewater, determine the possibilities of its use as an external denitrification substrate, and assess its overall impact on WWTP. The obtained results demonstrate that the analysed industrial wastewater is biodegradable, and can be used as a denitrification substrate without special adaptation of biomass. The denitrification rates with tested wastewater were in the range of 1.6 to 1.9 mgN/g·h. Negative influence of long-term dosing of industrial wastewater on activated sludge were not confirmed. The effect of imported wastewater on WWTP must be assessed comprehensively, including the impact of heavy metals from wastewater on the sludge quality. The instructions on how to calculate this balance are provided in the article.
Phosphate Ion Removal from Synthetic and Real Wastewater Using MnFe2O4 Nanoparticles: A Reusable Adsorbent
Authors: Brontowiyono Widodo , Patra Indrajit , Hussein Shaymaa Abed , Alimuddin Alimuddin , Mahdi Ahmed B. , Izzat Samar Emad , Al-Dhalemi Dhuha Mohsin , Aldulaim Ahmed Kareem Obaid , Parra Rosario Mireya Romero , Arenas Luis Andres Barboza , Mustafa Yasser Fakri
Published: September 2022

The purpose of this study was to eliminate phosphate (P) from wastewater using MnFe2O4 nanoparticles. BET, TGA/DTG, FTIR, SEM, TEM, VSM, XRD and EDX/Map analyses were used to determine the MnFe2O4 surface properties. The specific surface area of the adsorbent was 196.56 m2/g and VSM analysis showed that the adsorbent has a ferromagnetic property. The maximum P sorption efficiency using MnFe2O4 (98.52%) was achieved at pH 6, temperature of 55 °C, P concentration of 10 mg/L, time of 60 min, and sorbent dosage of 2.5 g/L, which is a significant value. Also, the thermodynamic study indicated that the P sorption process is spontaneous and endothermic. Moreover, the utmost sorption capacity of P using MnFe2O4 was 39.48 mg/g. Besides, MnFe2O4 can be used for up to 6 reuse cycles with high sorption efficiency (>91%). Also, MnFe2O4 was able to remove phosphate, COD, and BOD5 from municipal wastewater with considerable removal efficiencies of 82.7%, 75.8%, and 77.3%, respectively.
Syntheses, Structures and Insulin-Like Activity of Two Oxidovanadium(V) Complexes with Similar Nicotinohydrazone Ligands
Authors: Zhou Gao-Qi , Qiu Xiao-Yang , Liu Shu-Juan , Wang Chu-Yi
Published: September 2022

Two new oxidovanadium(V) complexes, [VOL1(HQ)] (1) and [VOL2(SAH)] (2), were prepared by the reaction of [VO(acac) 2] (where acac = acetylacetonate) with N’-(3-ethoxy-2-hydroxybenzylidene)nicotinohydrazide (H2L1) and 8-hydroxyquinoline (HHQ), and N’-(2-hydroxy-4-methoxybenzylidene)nicotinohydrazide (H2L2) and salicylhydroxamic acid (HSAH), respectively, in methanol. Crystal and molecular structures of the complexes were determined by elemental analysis, infrared spectroscopy and single crystal X-ray diffraction. The V atoms in both complexes are in octahedral coordination. Thermal stability of the complexes was studied. Both complexes can decrease the blood glucose level in alloxan-diabetic mice, but the blood glucose level in the treated normal mice was not altered.
Relative hypotension in emergency care v1
Authors: D van Oppen James
Published: September 2022

Investigation for the effect (on mortality & length of hospital stay) of hypotension at emergency care attendance relative to an individual's baseline
Spatial Multi-omics Sequencing for Fixed Tissue via DBiT-seq v1
Authors: Su Graham
Published: September 2022

This protocol describes the use of Deterministic Barcoding in Tissue for spatial omics sequencing (DBiT-seq) platform to construct a multi-omics atlas on fixed frozen tissue samples. This approach uses a microfluidic-based method to introduce combinatorial DNA oligo barcodes directly to the cells in a tissue section fixed on a glass slide. This technique does not directly resolve single cells but can achieve a near-single-cell resolution for spatial transcriptomics and spatial analysis of a targeted panel of proteins.
ADE 2022 Day 1: Background and Fieldwork v2
Authors: Little Tom
Published: September 2022

ADE 2022 description of work to be done on Day 1 of the practical work
Arabidopsis seeds priming v1
Authors: Chang Tao-Ho
Published: September 2022

The treated seeds can grow in medium or bulk soil to determine the impact of novel materials on plants.
A Glass Pendant from the Tenedos Necropolis
Authors: YAMAN Hüseyin
Published: September 2022

The male head-shaped glass pendant discussed in this study was found together with a terracotta statuette, a terracotta head (or a protome), and some knucklebones (astragali) in a pithos burial during rescue excavations in 1993 in the Tenedos necropolis. The rod-formed pendant has a beard, big eyes, a long nose, full lips, and a slightly protruding chin. Trails of opaque yellow, white, and turquoise glass were applied to the translucent dark blue body of the pendant. Such glass pendants are considered to be of Phoenician and/or Punic origin and are distributed throughout the Mediterranean basin, the northern coast of the Black Sea, and Eastern Europe. They range in date from the 7th century to the middle of the 1st century BC. The Tenedos glass pendant is compatible with M. Seefried’s “Type C” (male head with curly hair) and dated between the 5th century and 3rd century BC. It belongs to the C1 subgroup (head with curly hair and sleek beard) of this type. The head-shaped glass pendant is a rare find from the northeast region of the Aegean. In the context of the other finds from the tomb, notably the standing female figurine, the glass pendant can be said to belong to the first half of the 5th century BC. Moreover, this find indicates the contact between the Phoenician and/or Punic world and Tenedos in this period.
Elements by artificial Intelligence
Authors: Brunet Luc
Published: September 2022

This document presents a prompt art representation of chemical elements imagined by Midjourney artificial intelligence.
Ценностные ориентации преподавателей музыкальной школы
Authors: Chernova Zinaida Mikhailovna
Published: September 2022

Автор представляет результаты теоретического анализа проблемного поля ценностных ориентации в контексте профессиональной деятельности, на примере ценностных ориентации преподавателей музыкальной школы. Представлены результаты диагностики ценностей преподавателей музыкальной школы.
Социально-психологическая адаптация детей мигрантов в общеобразовательной школе
Authors: Gaidarenko Svetlana Maksimovna
Published: September 2022

В статье представлены результаты теоретического анализа феномена социально-психологической адаптации детей мигрантов в общеобразовательной школе. Автор делает вывод о том, что при проявлении взаимной эмпатийности между учениками, прохождение этапов учебной, социально-педагогической и культурной адаптации ученика-мигранта проходит не только более быстро, но и более результативно. Высокий уровень эмпатийности ребенка-мигранта способствует его успешной интеграции в школе. Высокий уровень эмпатийных проявлений коллектива гарантирует принятие нового ученика в классе и установление между ними положительных социальных связей.
К вопросу о роли социально-психологических характеристик личности в трудовой деятельности сотрудников агрокомплекса
Authors: Karaulov Vitaly Alekseevich
Published: September 2022

Автор представляет результаты теоретического осмысления проблемы социально-психологических характеристик персонала агрокомплекса в контексте осуществлении профессиональных обязанностей и влияние на межличностное взаимодействие. Автором развивает тезис, что свойства личности детерминируют социальную позицию сотрудника в организации и его дальнейшую траекторию профессионального развития.
Salgın sırasındaki elektronik ürün alımlarında karşılaştırmalı bir karar verme
Authors: KÖSEOĞLU Ali
Published: September 2022

Covid-19 salgını sürecinde ilköğretimden üniversitelere kadar neredeyse tüm dersler online eğitime dönüştürülmektedir. Dolayısıyla, bu salgın koşullarında elektronik ürünlere olan ihtiyaç artış göstermektedir. Öğrenciler elektronik ürünler, yani tabletler, dizüstü bilgisayarlar vb. satın almak istediklerinde kalite, özellik ve fiyat bakımından farklılık gösteren birçok farklı olası seçenekle karşı karşıya kalmaktadır. Çok kriterli karar verme yöntemleri, bu gibi durumlarda birçok alternatif arasından mümkün olan en iyi alternatifi seçmek için çok faydalı araçlardır. Bu nedenle, bu çalışmada, öğrencilerin çevrimiçi derslerde kullanmak üzere mümkün olan en iyi elektronik ürünü seçebilmeleri için iyi bilinen iki ÇKKV yöntemi ele alınmıştır.
Ni-B/hBN katkılı TMAB ve sakarinli kaplama malzemelerinde Ni için X-ışını floresans parametrelerinin ve valans elektronik yapısının incelenmesi
Authors: KÖKSAL Oğuz Kağan , KARAHAN İsmail Hakkı
Published: September 2022

Bu araştırmada, Ni-B alaşımlı kaplamalarda Ni'nin K kabuğu değerlik elektronik yapısı, X-ışını emisyonu ve XRD spektrumları toplanarak incelenmiştir. Elde edilen veriler K beta/K alfa X-ışını yoğunluk oranları ve XRD verileri açısından değerlendirildi. Kaplanmış alaşımlar, bu çalışma için farklı konsantrasyonlarda altıgen bor nitrür (hBN) kullanılarak elektrokimyasal depolama yöntemiyle üretilmiştir. Mevcut örneklere sabit konsantrasyonda sakarin ve trimetilamin boran kompleksi (TMAB) ilave edildi. Mevcut örnekler, 241 Am halka şeklindeki radyoaktif kaynaktan gelen 59.5 keV fotonları tarafından uyarıldı. Örneklerden yayılan K kabuk X-ışınları, 5,9 keV'de 150 eV çözünürlüğe sahip bir Ultra-LEGe dedektörü vasıtasıyla tespit edildi. Ni-B alaşımlarının K kabuğu X-ışını yoğunluk oranları saf Ni ile kontrol edildi. Mevcut sonuçlardaki değişimler, katkılı TMAB ve sakarin içeren Ni-B/hBN kaplama malzemelerinde Ni'nin değerlik elektronik yapılarındaki değişim ile yorumlanmıştır.
Two clinical cases of the reconstruction of distal phalanges of hand in children by combination of the regional flap and scrap bone and nailbed graft
Authors: Alexandrov Alexander V. , Goncharuk Pavel V. , Evdokimov Alexander N. , Idris Lamiya Ya. , Smirnov Alexander A. , Khagurov Ruslan A. , Samorukova Nina N. , Alexandrova Natalya Y.
Published: September 2022

BACKGROUND: The hand and its distal phalanges, especially in children, are among areas mostly exposed to trauma while contacting the environment. Injuries causing loss of soft tissue and bone component are both challenging and interesting. This report presents the treatment results of children with soft tissue and bone defects of distal phalanges, in which reconstructions including combination of regional flaps, bone, and nailbed grafts were performed.
CLINICAL CASE: This report presents clinical cases of the surgical treatment of 4- and 6-year-old children with fingertip injuries who underwent reconstructions including the combination of regional flaps, bone, and nailbed grafts. A combination of the scrap graft was performed in the first case with antegrade homodigital island flap and in the second case with thenar flap. The results were assessed 6 and 7 months after surgery.
DISCUSSION: The primary aim of the surgical treatment of children with distal phalangeal defects is coverage of those defects. The restoration of the bone component of the defect is recommended to prevent postoperative deformations of the distal phalanges. Fingertip replantation or microsurgical transplantation of vascularized tissue complexes are technically difficult and require thorough care and monitoring of the childs condition in the postoperative period as all these measures may fail.
CONCLUSIONS: The possibility to combine the scrap bone and nailbed graft with existing reliable surgical methods open new prospects for the successful treatment of fingertip injuries.
Treatment of fractures of the main phalanx of the fingers in children
Authors: Gordienko Ivan I. , Tsap Natalia A. , Kutepov Sergey M.
Published: September 2022

BACKGROUND: Fractures of the bones of the hand and wrist account for 25% of all fractures in children, whereas the phalanges are the most common localization of these injuries and account for 15%30% of all fractures of the upper limb. To fix fractures of the neck of the middle and main phalanx of the fingers, traumatologists resort to retrograde osteosynthesis with a spoke, which in all cases passes through the articular surface of the distal fragment, thereby blocking the joint adjacent to the fracture. This significantly complicated postoperative rehabilitation to restore movements.
AIM: This study aimed to comparatively analyze the results of extra-articular osteosynthesis of fractures of the distal metaphysis of the main phalanx of childrens fingers.
MATERIALS AND METHODS: A prospective cohort study included 52 children with fractures of the main phalanx of the fingers. The study cohort of children was divided into two groups. The main group included 29 children who underwent osteosynthesis of the distal fragment of the phalanx with spokes according to the authors method without passing them through the distal or proximal interphalangeal joint. The comparison group included 23 children who, during osteosynthesis, had spokes carried out retrogradely, through the articular surface of the distal phalanx fragment. The total volume of the restored active movements in the proximal interphalangeal joint was compared after 3, 6, and 12 weeks from the moment of surgery, including local signs of inflammation in the needle insertion site after 3 and 7 days from the moment of surgery.
RESULTS: In the main group, signs of inflammation were found only in 10% of the cases, whereas in the comparison group, more serious signs were observed, such as the release of exudate along the spokes in two cases on day 3. The average values of the amplitude of movements at week 3 in the main group are more than two times higher than the average values of the comparison group, 12.06 and 5.56, respectively. The volume of movements in the main group was restored more than two times more efficiently, and in several patients, by week 12, it was restored to 100 of the total volume of active movements in the joint (p 0.05).
CONCLUSIONS: The authors method of extra-articular and antegrade osteosynthesis of the fractures of the neck of the main phalanges in children made it possible to achieve better functional results in comparison with the standard method.
H. Turner National Medical Research Center for Children’s Orthopedics and Trauma Surgery is 90 years old
Authors: Vissarionov Sergei V. , Baindurashvili Alexey G. , Ovechkina Alla V. , Zaletina Anna V.
Published: September 2022

In 2022, H. Turner National Medical Research Center for Childrens Orthopaedics and Trauma Surgery of the Ministry of Health of the Russian Federation celebrates its 90th Anniversary. It is a unique and the only specialized institution in the world that treats children with orthopedic pathologies. The Center is known not only for its medical achievements, innovations and developments, but also for the amazing atmosphere of care and attention to children. The result of the activities of H. Turner National Medical Research Center is thousands of children who regained their ability to move and enjoy their childhood.
Strategi Pengembangan Bisnis Olahan Ikan Beku di PT XYZ
Authors: Sholeh Qolby Nuuran , Syarief Rizal , Suwandi Ruddy , Hidayat Taufik
Published: September 2022

Perkembangan makanan beku Indonesia mengalami peningkatan permintaan yang cukup signifikan pada saat situasi pandemic COVID-19. Perkembangan tersebut sejalan dengan kenaikan permintaan makanan olahan ikan beku Indonesia, yang kini mendapatkan nilai lebih dari masyarakat. Pengembangan bisnis olahan ikan memiliki potensi yang tinggi untuk dikembangkan, mengingat kemudahan dalam mendapatkan, menyimpan serta menyajikan untuk dihidangkan sebagai tambahan lauk dalam konsumsi keseharian. Tujuan penelitian adalah Menganalisis faktor internal dan eksternal olahan ikan PT XYZ, Merumuskan alternatif strategi pengembangan usaha PT XYZ, menentukan prioritas strategi kebijakan untuk pengembangan usaha PT XYZ. Pengambilan data dilakukan di PT XYZ yang berlokasi di Sidoarjo, Jawa Timur pada Juli hingga September 2021. Metode penelitian secara deskriptif, diolah dan dianalisis menggunakan matriks IFE, EFE, IE, SWOT dan QSPM. Hasil penelitian menunjukkan terdapat bahan baku ikan beku yaitu ikan swangi. Ada 7 alternatif strategi diantaranya yaitu menjual produk kepada distributor tunggal, produksi ikan segar beku, menambah jaringan distributor luar Jawa Timur, meningkatkan branding, mengolah ikan menjadi bubur ikan, dan kampanye ikan sebagai sumber protein. Prioritas yang dihasilkan dari penelitian adalah memproduksi ikan beku kualitas ekspor sebagai produk baru menjadi alternatif yang paling prioritas yang dapat dilakukan oleh perusahaan. Hingga saat ini komoditas ikan yang digunakan adalah ikan swanggi menjadi bahan baku utama perusahaan yang kemudian diolah menjadi aneka olahan ikan beku. Sehingga harapannya PT XYZ tidak hanya menjual produk di pasar domestik, akan tetapi pasar internasional menjadi sebuah peluang bagi perusahaan
Karakteristik Cone Es Krim Berbasis Tepung Cangkang Udang dengan Konsentrasi Karagenan yang Berbeda
Authors: Mandiri Ragil Tirta , Purnamayati Lukita , Fahmi Akhmad Suhaeli
Published: September 2022

Cone es krim merupakan kue kering berbentuk corong yang digunakan sebagai wadah untuk konsumsi es krim. Penambahan karagenan dapat memperbaiki karakteristik cone karena sifatnya sebagai hidrokoloid mampu mengikat air dan menghasilkan gel yang kokoh sehingga dapat menghasilkan cone yang lebih renyah dan lebih tahan lama. Konsumsi cone dapat diperkaya dengan kalsium yang berasal dari penambahan tepung cangkang udang yang dapat dimanfaatkan untuk mengurangi limbah. Tujuan dari penelitian ini adalah menentukan konsentrasi karagenan terbaik dengan penambahan tepung cangkang udang 5% dalam menghasilkan formulasi cone es krim. Metode penelitian yang digunakan adalah experimental laboratories dengan Rancangan Acak Lengkap menggunakan 4 perlakuan konsentrasi yaitu penambahan tepung cangkang udang 5% dengan karagenan 0; 0,75; 1,50 dan 2,25% serta dilakukan tiga kali ulangan. Data parametrik dianalisis menggunakan ANOVA dan dilanjutkan uji Beda Nyata Jujur apabila berbeda nyata. Data non parametrik dianalisis dengan uji Kruskal Wallis dan Mann-Whitney. Hasil penelitian menunjukkan perbedaan konsentrasi karagenan berpengaruh nyata terhadap karakteristik fisikokimia cone terutama perlakuan terbaik dengan penambahan karagenan 0,75% yang memiliki warna kecokelatan, aroma spesifik cone, rasa yang manis, bertekstur renyah serta memiliki nilai kadar air 2,44%; nilai tekstur 528,12 gf; ketahanan 27,82 menit serta mikrostruktur yang lebih rapat dan nilai hedonik rata-rata yang agak disukai panelis dengan selang kepercayaan 6,69<μ<7,44 yang berarti agak disukai panelis.
Türkiye’nin Nohut Dış Ticaretinde Karşılaştırmalı Üstünlüğünün Analizi
Authors: ÇAKAN Veli Anıl , TURHAN Şule
Published: September 2022

Türkiye’de ekim alanı ve üretim miktarı en yüksek kuru baklagil olan nohut, bu yönüyle ülke ekonomisi ve üretimi gerçekleştirilen coğrafyalardaki üretici açısından önemli bir tarımsal üründür. Bu çalışmada Türkiye’nin 2010-2020 yıllarında nohut sektöründeki karşılaştırmalı üstünlüğünün değerlendirilmesi amaçlanmıştır. Çalışmada kullanılan veriler TRADEMAP ve TÜİK istatistiklerinden temin edilmiştir. Karşılaştırmalı üstünlüğün hesaplanmasında Balassa indeksi olarak da bilinen açıklanmış karşılaştırmalı üstünlükler (RCA) indeksi ve Vollrath İndeksleri olarak da adlandırılan Nispi Ticaret Üstünlüğü (RTA), Nispi İhracat Üstünlüğü’nün logaritması (lnRXA) ve Açıklanmış Rekabetçilik (RC) indeksleri kullanılmıştır. Karşılaştırmalı üstünlüğü ölçmek için yararlanılan indeksler incelendiğinde, Türkiye nohut sektörünün RCA ve lnRXA indekslerine incelenen her yıl için karşılaştırmalı üstünlüğe sahip olduğu görülmüştür. Buna karşın ithalat değerlerini de dikkate alan RTA ve RC indekslerine göre 2012-2013 ve 2015-2017 yıllarında sektörün karşılaştırmalı dezavantaja sahip olduğu belirlenmiştir. Hesaplanan tüm indekslerde 2018 yılından itibaren önemli artışlar gerçekleşmiş ve Türkiye’nin nohut sektörü için karşılaştırmalı üstünlüğe sahip olduğu sonucuna ulaşılmıştır. Yapılan araştırmalar, gerçekleşen bu önemli değişimin Türkiye’de nohut için yapılan desteklemelerdeki artış ve nohut yeniden ihraç faaliyetleri ile ilişkilendirilebileceğini göstermiştir.
Coenzyme q10 and letrozole versus letrozole alone for ovulation induction in polycystic ovary syndrome
Authors: Nasrin Ivy , Ishrat Shakeela , Amir Mumtahena , Halder Suravi , Rahman Farzana , Kamruzzaman Mohammad
Published: September 2022

Background: Polycystic ovary syndrome (PCOS) is the largest single cause of anovulatory infertility. PCOS is associated with oxidative stress. Coenzyme q10 (Coq10) is an antioxidant that protects the mitochondria from damage caused by either insulin resistance or oxidative free radicals. The objective of the study was to compare the effect of combined Coq10 and letrozole than of letrozole alone for ovulation induction in women with PCOS.Methods: This open label parallel design randomized controlled trial study was conducted on 80 infertile women with PCOS selected for ovulation induction. Eligible women were randomized either to combined Coq10 and letrozole (40 patients, 83 cycles) or letrozole alone (38 patients, 91 cycles). The outcome measures were mature follicles, adequate endometrial thickness, ovulation and pregnancy.Results: Mature follicles (≥18-25 mm) were significantly higher in women given Coq10 at 2nd (74.2% vs 31.3%) and 3rd cycles (83.3% vs 28.6%). Adequate endometrial thickness was significantly higher in women given Coq10 in second (90.3% vs 56.3%) and third cycle (94.4% vs 47.6%). When Coq10 was added to letrozole, ovulation rates were significantly higher (87.1% vs 53.1% in second cycle), (83.3% vs 38.1%, in third cycle). Cumulative pregnancy was 2.37 times (95% CI 1.03-5.48) higher in women having Coq10 in addition to letrozole for ovulation induction. Conclusions: Coq10, as an adjuvant to ovulation induction with letrozole improves ovarian response, ovulation and pregnancy in PCOS women. Combination of Coq10 and letrozole can be tried successfully before a more complicated and expensive treatment such as gonadotrophins and laparoscopic ovarian drilling.
An integrated computational study for screening medicinal plant phytochemicals for possible inhibitors of the human bile salt exporter pump
Authors: Alshehri Dhafer B.
Published: September 2022

Background: The primary carrier of bile acids in humans is the bile salt export pump (BSEP). which are crucial for the digestion and absorption of fat. Type 2 progressive familial intrahepatic cholestasis (PFIC-2), which is brought on when BSEP is suppressed and causes a decrease in bile flow and a buildup of cytotoxic bile salts in the liver, is one of the main causes of cholestasis in Saudi Arabia. Elucidate the inhibitory potential with minimal or no adverse effects.Methods: The structure (6LR0) was downloaded from the PDB. Protein active sites were anticipated because these are pockets where ligands can bind and perform reactions to treat an infection. The PubChem zinc and mpd3 databases were used to get the ligands' structures. Molecular operating environment (MOE) was utilized to perform molecular docking of 1600 phytochemicals against BSEP. LigX was used to observe the docking hits for interaction analysis. Results: identification of 4 potential candidates for binding to the BSEP active site. then, Protox II-was used to forecast toxicity for the selected hits. Molecular dynamics simulations were also used to assess the binding complex's stability in water for 100 nanoseconds. The strong binding affinity of high-ranked drugs was predicted by our molecular docking and simulation.Conclusions: This approach could be useful in determining the efficiency of a therapeutic molecule in the therapy of the BSEP. The aim of this research is to identify novel -BSEP drug targets, and in future in vitro and in vivo research could prove its clinical efficiency.
Evaluation of rapid immunochromatographic card test in comparison with IgM ELISA in diagnosis of dengue fever at a tertiary care hospital, South India
Authors: Tabassum Samina Kausar , Ahmed Syed Imran
Published: September 2022

Background: Dengue has emerged as a major public health concern throughout India because of the mortality and morbidity associated with it. It is the most common mosquito-borne viral disease of humans. Hence early and rapid laboratory diagnosis of dengue is crucial. This study aims to determine demographic, clinical and laboratory investigations of all the suspected cases of dengue fever and comparison of two commercial tests routinely useful in diagnosis of dengue fever. This study was conducted to determine seropositivity of dengue samples in patients suspected of dengue illness and to compare immunochromatographic card test (ICT) test and IgM ELISA test.Methods: A total of 702 serum samples from patients with suspected dengue infection were included and the study was undertaken at department of microbiology at a tertiary care hospital, Hyderabad from July to December 2021. All samples were subjected to rapid ICT and confirmed by dengue IgM-capture ELISA.Results: Out of 702 cases suspected of dengue, 85 (12%) samples were positive by IgM ELISA method. The most affected age group was 21-40 years with 55 cases (64.3%) were positive, followed by the age group 0f 0-20 years with 25% of the cases. Males were affected more than females with a percentage of 54% and 46% respectively. The highest number of suspected dengue patients admitted was in the month of September, i.e., 140 with 16 positive (14.81%) followed by August 122 samples (12.16%) and October 110 samples with 14 (11.03%) positive. The sensitivity and specificity of ICT was 95.5% and 100% when compared with IgM-ELISA.Conclusions: Dengue cases were more during August to November in the monsoon and post monsoon season which is useful to plan special preventive strategies. This study draws attention toward the male, young and adult age group. To conclude, in countries lacking infrastructure for the diagnostic labs especially in the rural and remote areas, the rapid dengue ICT tests can play a major role in diagnosis and in patient management of acute dengue infection. The rapid ICTs are very simple, easy to perform, and can be used as point of care tests. We suggest that the rapid ICT for dengue detection may be used in patients presenting with febrile illness.
Real-world observational study to capture demographic details of newly diagnosed type 2 diabetes mellitus
Authors: Dalal Nishant , Patel Dixit , Chaturvedi Alok , Shah Ankita
Published: September 2022

Background: To understand the demographic profile of newly diagnosed type 2 diabetes mellitus (T2DM) patients and to evaluate the glycaemic status and initial treatment choices in this subset of T2DM patients.Methods: The ROD-IT-2 study was a real-world, retrospective, cross-sectional, observational study conducted at various centres across India between April 2021 and March 2022. The study outcomes included epidemiology, comorbidities, and management strategies preferred by Indian clinicians in these patients.Results: Data from 29,550 newly diagnosed T2DM patients were analyzed. The mean age of patients was 53.3 years, and majority were males (65%). Majority of patients (63.85%) were aged 40 to 60 years. More than half (53.11%) of the patients were either overweight (36.65%) or obese (16.76%). The mean glycated hemoglobin (HbA1c) was high (8.4%). Most (88.5%) patients had cardio-renal comorbidities. Hypertension was the most common comorbidity (45.7%) followed by dyslipidemia (32.1%). Chronic kidney disease (CKD) was also present in 31.2% patients. In the present study, 9.2% patients presented with microvascular complications at the time of diagnosis. Majority of newly diagnosed patients (79.7%) were treated with combination therapy. In patients who were prescribed dual drug combination therapy, metformin + dipeptidyl peptidase-4 inhibitor (DPP4i) was the preferred combination (42.71%)  followed by metformin + sulfonylurea (31.37%).Conclusions: ROD-IT-2 study showed that mean HbA1c levels in T2DM patients still remain high in our population and cardio-renal comorbidities remain prevalent in newly diagnosed patients. Indian clinicians were found to prefer the combination therapy in newly diagnosed T2DM patients.
A mapping review protocol for toothbrush design
Authors: Divate Smruti , Morse Zac
Published: September 2022

Background: A universal method of dental home care regimen has been toothbrushing. It aids with dental biofilm and plaque removal in an attempt to prevent chronic oral diseases. Although many comparative studies have been conducted on toothbrushes and their efficacy in plaque removal, there has been no systematic mapping review focusing on toothbrush design, ease of use and safety. This mapping review aims to map key concepts, categorise existing themes and identify gaps in existing literature for future primary or scoping studies.

Methods: The protocol for this mapping review has been designed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) and the Joanna Briggs Institute (JBI) guidelines. Primary and secondary studies, guidelines, and reports about the design, ease of use and safety of toothbrushes will be considered for inclusion in this mapping review. Four databases (Dentistry and Oral Sciences Source, CINAHL, MEDLINE, and Scopus) and three sources of unpublished literature (Cochrane Library, Google, and Google Scholar) will be searched using the JBI proposed three-stage search strategy by reviewers independently. A PRISMA-ScR flowchart will be utilised to document the numbers of identified, screened, and excluded sources. Data will be extracted using a data extraction table designed by the reviewers. Extracted data will be summarised and presented in diagrammatic and tabular forms, accompanied by a narrative explanation.

Conclusions: Examining the existing literature on toothbrush design is fundamental to guide future research, design innovations, and improve oral health.
Readmission rates and risk factors associated with emergency surgeries
Authors: Siddiqui Mohammad S. , Albawardi Abdulkarim A. , Alqahtani Meshari S. , Almarshadi Jamal A. , Alanazi Thamer A. , Alshammari Fahad H. , Almalki Marwan T. , Mohamed Dalal A. , Alamoudi Osama O. , Almalky Ayman J. , Alobaidi Ahmed E.
Published: September 2022

Emergency surgery requires complex and diversified skills and talents to execute procedures from several fields of surgery within 24 hours. The prevalence of emergency surgery is also increasing in recent times and the cohort for emergency general surgery is particularly at risk for readmission. Readmission is considered as one of the predictors of the quality of healthcare. Readmission following emergency surgery is frequent and varies greatly based on patient characteristics and diagnostic types. Readmission is associated with the significant morbidity and mortality, also adds to the increased hospital burden. Various risk factors account for the readmission. The purpose of this research is to review the available information about the readmission rates and risk factors associated with emergency surgeries. About half of patients undergoing emergency surgeries will experience a postoperative complication, and postoperative complications have a strong correlation with hospital readmission. Postoperative complications and readmission have a significant negative influence on patient quality of life and healthcare resources. Different studies have reported an increased prevalence of readmissions after emergency surgeries. Surgical site infection, increased length of hospital stays, readmission at the non-index hospital, comorbidities are some of the commonly reported risk factors of readmission. Establishment and implementation of the preventive strategies for the control of risk factors of readmission can help in reducing the readmission burden.
A multicenter, retrospective study to evaluate the effectiveness, safety, and utilization patterns of super bioavailable itraconazole 50 mg in superficial dermatophytic infections
Authors: Khanna Vinod , Hussain Juzer , Patel Shruti , Patel Dixit , Chaturvedi Alok , Shah Ankita
Published: September 2022

Background: Objectives of the study were to assess the clinical characteristics of patients with superficial dermatophytic infections, and to evaluate the safety and effectiveness of super bioavailable (SB) itraconazole 50 mg.

Methods: In this cross-sectional observational study, data of patients with superficial dermatophytic infections treated as per physician’s discretion was collected retrospectively from 71 centers across India between April 2021 and March 2022. Patient’s demographics, prescribing patterns of SB-itraconazole, and clinician-rated effectiveness and safety were evaluated.

Results: Of 432 analyzed patients, 72.22% (n=312) had new infections, 27.77% (n=120) had recalcitrant/recurrent infections. Majority of the patients were males (66%) and aged 21-40 years (72.45%). Tinea corporis (27.08%) was the most common fungal infection followed by Tinea cruris (20.60%). SB-itraconazole was most commonly prescribed with water (63.88%; n=276); majority (55.8%) of the patients received SB-itraconazole post-meals. Majority of the patients achieved clinical (naïve: 71.47%; recalcitrant: 79.17%) cures within 4 weeks. The efficacy was excellent/good in 71.95% of patients who received SB-itraconazole as the first choice over conventional itraconazole for overall benefits as per the clinician’s global assessment; and in 87.22% of patients who received concomitant acid-lowering drugs. Most (83.33%) patients reported excellent/good compliance with SB-itraconazole. The clinicians’ rated this newer formulation of itraconazole (SB-itraconazole) as excellent/good in efficacy (83.33%) and safety (79.17%) for most patients.

Conclusions: SB-itraconazole was effective and safe in patients with superficial dermatophytic infections. The effectiveness of SB-itraconazole was similar with high response rates for naïve and recalcitrant cases. Further, the efficacy was excellent/good in most patients receiving SB-itraconazole as the first choice over conventional itraconazole, or who received concomitant acid-lowering drugs.
Diagnostic predicaments in a case of Intestinal obstruction with strictures to distinguish intestinal Koch’s and Crohn’s disease
Authors: Kambale Tushar Jalindar , Jose Merin , Garg Anshita , Gore Charusheela
Published: September 2022

Intestinal Tuberculosis (Koch’s) has become a very common disease which pose a great diagnostic challenge because of its non- specific presentation and broad-spectrum features and lead to delays in diagnosis along with developments of complications. This 70 years old female patient presented with intestinal obstruction with multiple strictures. It was very tough to distinguish Tuberculosis from Crohn’s Disease in this case as the sections for histology were continuously negative for Acid fast bacilli. This case demonstrates the diagnostic predicaments encountered to arrive at a diagnosis of Intestinal Tuberculosis.