bluuebunny/crossref_metadata_2025 huggingface dataset:
Improvements in Body Composition after a Proposed Anti-Inflammatory Diet Are Modified by Employment Status in Weight-Stable Patients with Rheumatoid Arthritis, a Randomized Controlled Crossover Trial
Authors: Hulander Erik , Lindqvist Helen M. , Wadell Anna Turesson , Gjertsson Inger , Winkvist Anna , Bärebring Linnea
Published: March 2022

Rheumatoid Arthritis (RA) is an autoimmune disease affecting peripheral joints. Chronic activation of inflammatory pathways results in decreased function and the development of comorbidities, such as loss of lean mass while retaining total body mass. The objective of this report was to assess whether dietary manipulation affects body composition in patients with RA as a secondary outcome. Fifty patients were included in a randomized controlled crossover trial testing a proposed anti-inflammatory Mediterranean-style diet compared to a Western diet. Body composition was measured by bioelectrical impedance spectroscopy in patients without implants (n = 45). Regardless of treatment, fat-free mass increased and fat mass percentage decreased during weight stability, but no differences between intervention and control in the whole group (n = 42, all p > 0.20) were found. Interaction analysis revealed that participants who were non-employed (n = 15) significantly decreased in fat mass (−1.767 kg; 95% CI: −3.060, −0.475, p = 0.012) and fat mass percentage (−1.805%; 95% CI: −3.024, −0.586, p = 0.008) from the intervention compared to the control period. A Mediterranean-style diet improved body composition in non-employed participants (n = 15). The group as a whole improved regardless of dietary allocation, indicating a potential to treat rheumatoid cachexia by dietary manipulation.
Food-Related Carbonyl Stress in Cardiometabolic and Cancer Risk Linked to Unhealthy Modern Diet
Authors: Iacobini Carla , Vitale Martina , Haxhi Jonida , Pesce Carlo , Pugliese Giuseppe , Menini Stefano
Published: March 2022

Carbonyl stress is a condition characterized by an increase in the steady-state levels of reactive carbonyl species (RCS) that leads to accumulation of their irreversible covalent adducts with biological molecules. RCS are generated by the oxidative cleavage and cellular metabolism of lipids and sugars. In addition to causing damage directly, the RCS adducts, advanced glycation end-products (AGEs) and advanced lipoxidation end-products (ALEs), cause additional harm by eliciting chronic inflammation through receptor-mediated mechanisms. Hyperglycemia- and dyslipidemia-induced carbonyl stress plays a role in diabetic cardiovascular complications and diabetes-related cancer risk. Moreover, the increased dietary exposure to AGEs/ALEs could mediate the impact of the modern, highly processed diet on cardiometabolic and cancer risk. Finally, the transient carbonyl stress resulting from supraphysiological postprandial spikes in blood glucose and lipid levels may play a role in acute proinflammatory and proatherogenic changes occurring after a calorie dense meal. These findings underline the potential importance of carbonyl stress as a mediator of the cardiometabolic and cancer risk linked to today’s unhealthy diet. In this review, current knowledge in this field is discussed along with future research courses to offer new insights and open new avenues for therapeutic interventions to prevent diet-associated cardiometabolic disorders and cancer.
A Survey to Identify the Current Management of Cow’s Milk Disorders and the Role of Goat Milk-Based Formulas in the Middle East and North Africa Region
Authors: Bahbah Wael A. , ElHodhod Mostafa , Salah Mohamed , AlRefaee Fawaz , AlTuraiki Muath , Mousa Samira , Al Mehaidib Ali , Ayesh Wafaa Helmi , El-Bazzar Ahmed N. , El Haddad Joseph , El Khashab Heba Y. , El Zawahry Amr , Hasosah Mohammed , Shaaban Sanaa Youssef , Vandenplas Yvan
Published: March 2022

Background: Cow’s milk allergy (CMA) and cow’s milk intolerance (CMI) are the major cow’s milk disorders observed in infants and young children. This study investigates, for the first time, physician knowledge regarding CMA and CMI prevalence, diagnosis, and management in the Middle East and North Africa (MENA) region. In addition, we explore the role of goat milk-based formula as an alternative in infants suffering from CMI. Method: This cross-sectional survey was conducted from December 2020 to February 2021. A convenience sample of 2500 MENA-based physicians received the questionnaire, developed by a working group of pediatric experts. Results: 1868 physicians completed the questionnaire, including pediatric specialists (80.8%), training physicians (0.2%), dermatologists (0.1%), family/general physicians (12.9%), neonatologists (3.6%), neurosurgeons (0.2%), allergy nurse specialists (0.3%), pharmacists (2.1%), and public health workers (0.1%). Differentiation between CMA and CMI was recognized by the majority of respondents (80.7%), for which the majority of respondents (35.4%) identified that the elimination and challenge test was the best test to differentiate CMA from CMI, whereas 30.7% and 5.4% preferred the immunoglobulin E (IgE) test and skin prick test, respectively. In addition, 28.5% of respondents reported that there is no confirmatory test to differentiate CMA from CMI. The majority of respondents (47.3%) reported that amino acid-based formula (AAF)/ extensively hydrolyzed formula (EHF) is the cornerstone for the management of CMA. However, most respondents (33.7%) reported that lactose avoidance was best for the management of CMI. Overall, 65% of the respondents were aware of nutritionally adapted goat’s milk formula as an alternative to cow’s milk products and 37% would recommend its routine use in infants (≤2 years of age). Conclusion: The results of this survey demonstrate that the majority of physicians are aware of the underlying pathophysiology and management of CMA and CMI. However, a significant proportion of physicians do not follow the clinical guidelines concerning CMA/CMI diagnosis and management. Notably, this survey identified that goat’s milk formulas may offer a suitable alternative to AAF/EHF in infants with CMI as they contain β-casein protein which is easily digestible. In addition, goat’s milk formulas contain higher levels of oligosaccharides and medium-chained fatty acids compared with standard cow’s milk formulas, yet further clinical trials are warranted to support the inclusion of goat’s milk formulas in clinical guidelines.
How Do We Assess Energy Availability and RED-S Risk Factors in Para Athletes?
Authors: Jonvik Kristin L. , Vardardottir Birna , Broad Elizabeth
Published: March 2022

Low energy availability (LEA) is considered to be the underlying cause of a number of maladaptations in athletes, including impaired physiological function, low bone mineral density (BMD), and hormonal dysfunction. This is collectively referred to as ‘Relative Energy Deficiency in Sport’ (RED-S). LEA is calculated through assessment of dietary energy intake (EI), exercise energy expenditure (EEE) and fat-free mass (FFM). The incidence of LEA in Paralympic athletes is relatively unknown; however, there are legitimate concerns that Para athletes may be at even higher risk of LEA than able-bodied athletes. Unfortunately, there are numerous issues with the application of LEA assessment tools and the criterion for diagnosis within the context of a Para population. The calculation of EEE, in particular, is limited by a distinct lack of published data that cover a range of impairments and activities. In addition, for several RED-S-related factors, it is difficult to distinguish whether they are truly related to LEA or a consequence of the athlete’s impairment and medical history. This narrative review outlines deficits and complexities when assessing RED-S and LEA in Para athletes, presents the information that we do have, and provides suggestions for future progress in this important area of sports nutrition.
Taxifolin Alleviates DSS-Induced Ulcerative Colitis by Acting on Gut Microbiome to Produce Butyric Acid
Authors: Li Wei , Zhang Le , Xu Qingbiao , Yang Wenbo , Zhao Jianan , Ren Ying , Yu Zhendong , Ma Libao
Published: March 2022

Taxifolin is a bioflavonoid which has been used to treat Inflammatory Bowel Disease. However, taxifolin on DSS-induced colitis and gut health is still unclear. Here, we studied the effect of taxifolin on DSS-induced intestinal mucositis in mice. We measured the degree of intestinal mucosal injury and inflammatory response in DSS treated mice with or without taxifolin administration and studied the changes of fecal metabolites and intestinal microflora using 16S rRNA. The mechanism was further explored by fecal microbiota transplantation. The results showed that the weight loss and diarrhea score of the mice treated with taxifolin decreased in DSS-induced mice and longer colon length was displayed after taxifolin supplementation. Meanwhile, the expression of GPR41 and GPR43 in the colon was significantly increased by taxifolin treatment. Moreover, the expression of TNF-α, IL-1β, and IL-6 in colon tissue was inhibited by taxifolin treatment. The fecal metabolism pattern changed significantly after DSS treatment, which was reversed by taxifolin treatment. Importantly, taxifolin significantly increased the levels of butyric acid and isobutyric acid in the feces of DSS-treated mice. In terms of gut flora, taxifolin reversed the changes of Akkermansia, and further decreased uncultured_bacterium_f_Muribaculaceae. Fecal transplantation from taxifolin-treated mice showed a lower diarrhea score, reduced inflammatory response in the colon, and reduced intestinal mucosal damage, which may be related to the increased level of butyric acid in fecal metabolites. In conclusion, this study provides evidence that taxifolin can ameliorate DSS-induced colitis by altering gut microbiota to increase the production of SCFAs.
Atherogenic Index of Plasma and Its Association with Risk Factors of Coronary Artery Disease and Nutrient Intake in Korean Adult Men: The 2013–2014 KNHANES
Authors: Shin Hye Ran , Song SuJin , Cho Jin Ah , Ly Sun Yung
Published: March 2022

Coronary artery disease (CAD) has been linked to one of the highest death rates globally. The atherogenic index of plasma (AIP) may be an important predictor of atherosclerosis and cardiovascular disease, superior to the standard atherosclerotic lipid profile. This study investigated the relationship between AIP and obesity indices, blood glucose, lipid profile, and nutrient intake status in Korean adult men. The study included 1292 males aged ≥19 years old who participated in the Korea National Health and Nutrition Examination Survey, 2013–2014. Participants were divided into four groups according to AIP quartiles, calculated as log (triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C)). Body mass index, waist circumference, fasting blood glucose, hemoglobin A1c, total cholesterol, TG, and low-density lipoprotein cholesterol levels increased as AIP levels increased, whereas HDL-C level declined. As the level of AIP increased, intake of saturated fatty acid, calcium, phosphorus, riboflavin, milk, and dairy product decreased significantly, and the contribution rate of milk and dairy products to fat intake decreased. AIP was linked to obesity indices, blood glucose, and blood lipid profile in Korean men, suggesting that it could predict CAD.
Acetic Acid as Processing Aid Dramatically Improves Organic Solvent Solubility of Weakly Basic Drugs for Spray Dried Dispersion Manufacture
Authors: Adam Molly , Miller Warren , Pluntze Amanda , Stewart Aaron , Cape Jonathan , Grass Michael , Morgen Michael
Published: March 2022

Many active pharmaceutical ingredients (APIs) in the pharmaceutical pipeline require bioavailability enhancing formulations due to very low aqueous solubility. Although spray dried dispersions (SDDs) have demonstrated broad utility in enhancing the bioavailability of such APIs by trapping them in a high-energy amorphous form, many new chemical entities (NCEs) are poorly soluble not just in water, but in preferred organic spray drying solvents, e.g., methanol (MeOH) and acetone. Spraying poorly solvent soluble APIs from dilute solutions leads to low process throughput and small particles that challenge downstream processing. For APIs with basic pKa values, spray solvent solubility can be dramatically increased by using an acid to ionize the API. Specifically, we show that acetic acid can increase API solubility in MeOH:H2O by 10-fold for a weakly basic drug, gefitinib (GEF, pKa 7.2), by ionizing GEF to form the transient acetate salt. The acetic acid is removed during drying, resulting in a SDD of the original GEF free base having performance similar to SDDs sprayed from solvents without acetic acid. The increase in solvent solubility enables large scale manufacturing for these challenging APIs by significantly increasing the throughput and reducing the amount of solvent required.
Micro-RNA-Regulated SQUAMOSA-PROMOTER BINDING PROTEIN-LIKE (SPL) Gene Expression and Cytokinin Accumulation Distinguish Early-Developing Male and Female Inflorescences in Oil Palm (Elaeis guineensis)
Authors: Tregear James W. , Richaud Frédérique , Collin Myriam , Esbelin Jennifer , Parrinello Hugues , Cochard Benoît , Nodichao Leifi , Morcillo Fabienne , Adam Hélène , Jouannic Stefan
Published: March 2022

Sexual differentiation of inflorescences and flowers is important for reproduction and affects crop plant productivity. We report here on a molecular study of the process of sexual differentiation in the immature inflorescence of oil palm (Elaeis guineensis). This species is monoecious and exhibits gender diphasy, producing male and female inflorescences separately on the same plant in alternation. Three main approaches were used: small RNA-seq to characterise and study the expression of miRNA genes; RNA-seq to monitor mRNA accumulation patterns; hormone quantification to assess the role of cytokinins and auxins in inflorescence differentiation. Our study allowed the characterisation of 30 previously unreported palm MIRNA genes. In differential gene and miRNA expression studies, we identified a number of key developmental genes and miRNA-mRNA target modules previously described in relation to their developmental regulatory role in the cereal panicle, notably the miR156/529/535-SQUAMOSA PROMOTER-BINDING PROTEIN-LIKE (SPL) gene regulatory module. Gene enrichment analysis highlighted the importance of hormone-related genes, and this observation was corroborated by the detection of much higher levels of cytokinins in the female inflorescence. Our data illustrate the importance of branching regulation within the developmental window studied, during which the female inflorescence, unlike its male counterpart, produces flower clusters on new successive axes by sympodial growth.
Sustainable Antibacterial and Antiviral High-Performance Copper-Coated Filter Produced via Ion Beam Treatment
Authors: Jung Sunghoon , Yang Jun-Young , Jang Donghwan , Kim Taeyoon , Baek Ki Ho , Yoon Hyunkyung , Park Joo Young , Kim Sang Kwon , Hong Jinhyuk , Ryoo Sungweon , Jang Ho Won , Lee Seunghun
Published: March 2022

With the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), disease prevention has become incredibly important. Consequently, mask and air-purifier use has increased. The filter is the core component of these items. However, most filter materials lack antimicrobial properties. Copper is a sustainable antimicrobial material. When copper is deposited onto the filter’s surface, the microorganisms that come into contact with it can be effectively inactivated. In this study, we used an oxygen ion beam with a controlled process temperature to treat filter surfaces with copper. This enabled a strong adhesion of at least 4 N/cm between the copper and the filter fibers without damaging them. Upon exposing the filter to bacteria (Staphylococcus aureus ATCC 6538, Klebsiella pneumoniae ATCC 4352, Escherichia coli ATCC 25922, and Pseudomonas aeruginosa ATCC 27853) for one hour, a >99.99% removal rate was attained; when the filter was exposed to SARS-CoV-2 virus for one hour, it inactivated more than 99%. These beneficial properties minimize the risk of secondary infections, which are significantly more likely to occur when a conventional filter is replaced or removed.
A Sprayable and Visible Light Rapid-Cured Strippable Film for Surface Radioactive Decontamination
Authors: Zhang Huiyuan , Zhang Hongxing , Zhu Wenchao , Xi Hailing , Ma Bomou , He Yong
Published: March 2022

Strippable film is effective for removing radioactive contamination. However, it still has some limitations, such as the long curing time (about 30 min~24 h) and the requirement of organic solvents. To address these issues, we report a simple protocol to prepare strippable decontamination films using liquid polybutadiene (LPB) and tert-butyl acrylate (TBA) as the raw materials without solvent and using camphorquinone/ethyl 4-dimethylaminobenzoate (CQ/EDB) as a photoinitiator, where the film was formed under household LED panel light or daylight irradiation for about 540 s. After a thorough study of viscosity, real-time Fourier transform infrared (RT-FTIR spectra), gel and volatile organic compound (VOC) contents, mechanical properties and decontamination efficiency, the optimum composition and curing conditions were determined for the decontamination strippable film. VOC content is as low as 12.7 ± 0.7% and the resultant strippable film exhibits good mechanical performances with a tensile strength of up to 5.4 ± 0.4 MPa and elongation of up to 66.6 ± 13%. Most important, the decontamination efficiencies of this strippable film for 133CsCl on glass, ceramic and metal surfaces reach up to 98.1%, 94.3% and 97.6%, respectively.
Polymeric Nanoparticles-Loaded Hydrogels for Biomedical Applications: A Systematic Review on In Vivo Findings
Authors: Nunes Débora , Andrade Stéphanie , Ramalho Maria João , Loureiro Joana A. , Pereira Maria Carmo
Published: March 2022

Clinically available medications face several hurdles that limit their therapeutic activity, including restricted access to the target tissues due to biological barriers, low bioavailability, and poor pharmacokinetic properties. Drug delivery systems (DDS), such as nanoparticles (NPs) and hydrogels, have been widely employed to address these issues. Furthermore, the DDS improves drugs’ therapeutic efficacy while reducing undesired side effects caused by the unspecific distribution over the different tissues. The integration of NPs into hydrogels has emerged to improve their performance when compared with each DDS individually. The combination of both DDS enhances the ability to deliver drugs in a localized and targeted manner, paired with a controlled and sustained drug release, resulting in increased drug therapeutic effectiveness. With the incorporation of the NPs into hydrogels, it is possible to apply the DDS locally and then provide a sustained release of the NPs in the site of action, allowing the drug uptake in the required location. Additionally, most of the materials used to produce the hydrogels and NPs present low toxicity. This article provides a systematic review of the polymeric NPs-loaded hydrogels developed for various biomedical applications, focusing on studies that present in vivo data.
Building Religion through Dialogue: David Hume in Conversation with Twentieth-Century Philosophy of Dialogue
Authors: Dessy Valeria
Published: March 2022

The final part of David Hume’s Dialogues concerning Natural Religion has often left Hume’s readers perplexed. After a long and articulate debate between Philo, the skeptic, and Cleanthes, the theistic philosopher, the reader would expect the victory of Philo, whom many considered to be Hume’s spokesperson. Surprisingly, the book ends with the victory of Cleanthes. Keith Yandell suggested that none of these personages represented Hume, and that Philo’s change of mind was a “change of perspective”, epistemologically grounded in the concept of “propensities”, which Hume presented in The Natural History of Religion. In this article, I build on Yandell’s analysis and explore the dialogical dynamic of Hume’s work with the use of the twentieth-century philosophy of dialogue. I first focus on Michael Bakhtin’s analysis of Fyodor Dostoevsky’s books and show that, as in Bakhtin’s analysis, Hume does not orient the plurality of voices based on a pre-made understanding of reality. I then bring Hume into conversation with Martin Buber, especially regarding their epistemological standpoint. The aim of the article is to show the relevance of Hume’s thought for our contemporary philosophy of dialogue.
Multi-Sensor Fusion Self-Supervised Deep Odometry and Depth Estimation
Authors: Wan Yingcai , Zhao Qiankun , Guo Cheng , Xu Chenlong , Fang Lijing
Published: March 2022

This paper presents a new deep visual-inertial odometry and depth estimation framework for improving the accuracy of depth estimation and ego-motion from image sequences and inertial measurement unit (IMU) raw data. The proposed framework predicts ego-motion and depth with absolute scale in a self-supervised manner. We first capture dense features and solve the pose by deep visual odometry (DVO), and then combine the pose estimation pipeline with deep inertial odometry (DIO) by the extended Kalman filter (EKF) method to produce the sparse depth and pose with absolute scale. We then join deep visual-inertial odometry (DeepVIO) with depth estimation by using sparse depth and the pose from DeepVIO pipeline to align the scale of the depth prediction with the triangulated point cloud and reduce image reconstruction error. Specifically, we use the strengths of learning-based visual-inertial odometry (VIO) and depth estimation to build an end-to-end self-supervised learning architecture. We evaluated the new framework on the KITTI datasets and compared it to the previous techniques. We show that our approach improves results for ego-motion estimation and achieves comparable results for depth estimation, especially in the detail area.
Robust Sliding Mode Control for Stochastic Uncertain Discrete Systems with Two-Channel Packet Dropouts and Time-Varying Delays
Authors: Sun Sian , Cui Wenxia , Zheng Jie
Published: March 2022

In this paper, the control problem is investigated for discrete time-varying delayed systems with stochastic uncertainty, external disturbance, and two-channel packet dropouts. Sliding mode functions with packet loss probabilities are proposed for the packet loss problem in the sensor–controller channel and the controller–actuator channel. Furthermore, by employing the Lyapunov–Krasovskii functional, some new stability conditions are established in terms of solvable linear matrix inequalities (LMIs), and H∞ performance is analyzed for the sliding mode motion of the system. Meanwhile, a sliding mode controller is designed to drive the system state to the pre-designed sliding surface. Moreover, the designed controller can be robust for two-channel packet dropouts, time-varying delays, stochastic uncertainty and external disturbance. Finally, two numerical examples are given to demonstrate the feasibility of the proposed theoretical method.
Interorganizational Cooperation and Social Capital Formation among Social Enterprises and Social Economy Organizations: A Case Study from the Region of Attica, Greece
Authors: Oudeniotis Nectarios , Tsobanoglou George O.
Published: March 2022

Measuring social capital has been a challenging task over the past few decades, and, still, many of its dimensions and manifestations have not been thoroughly or evidently explored. The possible causes may be the ever-changing evolutionary perspectives that take place within the various levels of analysis—micro, meso, and macro—or within the various settings, where some of its core dimensions—bonding, bridging, and linking—are developed, or even among the contexts where its core determinants and features—trust, norms, connections, ties, etc.—are observed. Having in mind the various streams of research and theoretical discourses on social capital formation, this paper aims to surface the identification of the possible evidence on the formation of social capital among social economy organizations, and particularly among social enterprises. In doing so, it aims to explore the relational and cognitive features that drive social enterprises in their interorganizational cooperation with other social enterprises and third-sector organizations. The findings suggest that the central components of social capital, such as the sharing of common values, trust, reciprocity, and trustworthiness, are among those features that were valued most among the participants in the survey during their cooperation and engagement in common activities with other organizations.
Using the Community Engagement Framework to Understand and Assess EJ-Related Research Efforts
Authors: Williamson Dana H. Z.
Published: March 2022

Within an environmental justice frame, capacity-building has been an important component of efforts to address health disparities at the policy, system, and environment levels. While the literature is replete with studies that discuss the necessity of collective action as a means to generate power to overcome inequities, limited attention has been given to the structure of these efforts to build capacity and challenge environmental injustices. This study applies the community engagement continuum as a framework for understanding the scope of capacity-building strategies and the manner in which research investigators engage with their intended target community. Paired teams of independent analysts screened articles for relevance (n = 8452), identified records for content abstraction (n = 163), and characterized relevant studies (n = 58). Many articles discussed community engagement as being either collaborative or shared leadership (n = 32, 55.2%). While the most commonly used capacity-building strategies were organizing/social action (58.6%) and CBPR (50%), few studies were able to make an environmental impact (n = 23; 39.7%), and fewer had a direct legislative policy-related outcome (n = 13; 22.4%). This review identifies levels of collaborative involvement and strategic approaches used for strengthening community capacity in efforts of making transformative policy, systems, and environmental change.
The Influence of Collaboration on Enterprises Internationalization Process
Authors: Andres Beatriz , Poler Raul , Guzman Eduardo
Published: March 2022

At present, competitive globalized environments force enterprises to make more effort to both set up collaborative processes among networked partners and open their borders to the internationalization process. With this participation in internationalization processes, a set of barriers emerges that enterprises must overcome, particularly SMEs. The internationalization barriers are classified in four main dimensions, namely, strategy, technology, partners and product, which are considered to establish relationships between the internationalization and the collaborative processes. Accordingly, the research objective is to analyse the extent to which collaboration with international partners facilitates the internationalization process. A research survey was held with Spanish manufacturing SMEs to assess the internationalization of operations by establishing collaborative processes in global networks. Two surveys were conducted to analyse collaboration and internationalization concepts, and the influences among them: (i) a first survey, designed to validate the posed hypothesis about the relation between internationalization and setting up collaborative processes; (ii) a second survey, devised to perform a descriptive analysis that identifies less-applied collaborative processes in SMEs by establishing internationalization activities. The study results reveal that collaboration positively influences the internationalization process, and identifies the collaborative processes that are less performed among the partners that internationalize their operations.
Transmission Factor (TF) Behavior of Bi2O3–TeO2–Na2O–TiO2–ZnO Glass System: A Monte Carlo Simulation Study
Authors: Tekin Huseyin O. , ALMisned Ghada , Susoy Gulfem , Ali Fatema T. , Baykal Duygu Sen , Ene Antoaneta , Issa Shams A. M. , Rammah Yasser S. , Zakaly Hesham M. H.
Published: March 2022

The main objective of the present work was to assess the gamma radiation shielding competencies and gamma radiation transmission factors (TFs) for some tellurite glasses in the form of Bi2O3–TeO2–Na2O–TiO2–ZnO. MCNPX general-purpose Monte Carlo code (version 2.6.0) was utilized for the determination of TF values at various well-known radioisotope energies for different glass thicknesses from 0.5 cm to 3 cm. Moreover, some important gamma ray shielding properties were also determined in the 0.015–15 MeV energy range. The results show that glass densities were improved from 5.401 g/cm3 to 6.138 g·cm3 as a function of Bi2O3 increment in the glass composition. A S5 glass sample with the maximum Bi2O3 additive was reported with superior gamma ray shielding properties among the studied glasses. It can be concluded that Bi2O3 can be used as a functional tool in terms of improving glass density and, accordingly, gamma ray shielding attenuation properties of tellurite glasses, where the role Bi2O3 is also critical for other material properties, such as structural, optical, and mechanical.
Analysis of Current and Qualified Major Grain Producing Areas in China in the Last 30 Years
Authors: Lei Chengcheng , Qi Qingwen , Jiang Lili , Fu Yan , Liang Qizhang
Published: March 2022

China’s grain production has been on a pathway parallel to urbanization in the last 30 years. When the balance between the grain supply and demand is considered, contradiction between farming suitability and actual deviation provides warning of a crisis regarding China’s food security. In this study, we constructed a set of topologic maps to summarize the basic distribution of the farming conditions in China, and Kernel density and Local Moran’s I analyses were con-ducted to investigate the spatial-temporal pattern of China’s regional grain production based on the grain output at the county level from 1985 to 2019. The results show that the high-output zones were concentrated in the regions with superior physical conditions in 1985, and by 2019, the high-output zones had increased in the northern regions (i.e., Northeast China Plain) and decreased in the southern regions (i.e., Southern China). The surplus zones of per capita grain output were concentrated in the regions with high total outputs during 1985–2019. The shortage zones were distributed in the regions with low total outputs and low total outputs or large populations. Based on the above three results, several typical commodity grain bases have lost their dominant role (i.e., the Pearl River Delta); furthermore, the qualified commodity grain bases were compiled at both the national and regional level based on overlay analysis (i.e., the Tarbagatay Prefecture as well as eastern and central Inner Mongolia).
Pre-Recorded Lectures, Live Online Lectures, and Student Academic Achievement
Authors: Le Kien
Published: March 2022

In the midst of the COVID-19 pandemic, universities throughout the world are embracing online learning, often depending on synchronous and asynchronous digital communications. In this paper, we compare the impacts of live online (synchronous) and pre-recorded (asynchronous) lectures on student achievement using a randomized experiment. We discovered that pre-recorded lectures reduce lower-ability students’ academic achievement but have no effect on higher-ability students’ academic achievement. In particular, being taught via pre-recorded lectures as opposed to live online lectures decreased the likelihood of answering exam questions correctly by 1.6 percentage points for students in the bottom 50th percentile of the ability distribution (measured by GPA at the beginning of the semester). Furthermore, being taught via pre-recorded lectures in the starting weeks of the semester compared to the later weeks tended to be more harmful to students’ academic achievement. These findings have important implications for the effective design of education policies.
Managed Lane as Strategy for Traffic Flow and Safety: A Case Study of Catania Ring Road
Authors: Cafiso Salvatore , Di Graziano Alessandro , Giuffrè Tullio , Pappalardo Giuseppina , Severino Alessandro
Published: March 2022

According to international traffic statistics, the quantity of daily traveling vehicles amounts to one billion, and it is estimated that in 2050 that amount will reach four billion. Urban population is growing especially in large metropolitan areas. This increase has different outgrowths concerning regular circulation, safety, and climatic perspectives. Therefore, the present and further increase of traffic flow is affecting the operational and safety performance of several roadway categories. Urban ring roads belong to a roadway category that is particularly subjected to congestion phenomena, but in many cases, public administrations are unable to afford required expenses to upgrade or build new roadways. Therefore, an intervention is needed that increases the capacity of existing infrastructures with limited cost results to be fundamental. In such a framework, the dynamic use of hard shoulder running (HSR) would represent a valid solution that both exploits existing infrastructures and facilitates traffic outflow by implementation of smart digital roads, with limited interventions on the physical infrastructure. Despite the expected improvements in traffic capacity, the HSR poses safety issues particularly in specific locations (e.g., interchanges) and for the operation of the transition phase for opening and closing the HSR. In this paper, the applicability and usefulness of microsimulation were tested with the Catania (Italy) ring road, as a case study, through the application of VISSIM traffic microsimulation software and SSAM traffic conflict tool, implementing different scenarios for the activation of the HSR.
Investigation on the Potential of Various Biomass Waste for the Synthesis of Carbon Material for Energy Storage Application
Authors: Lim Brenda Ai-Lian , Lim Steven , Pang Yean Ling , Shuit Siew Hoong , Wong Kam Huei , Ooi Jong Boon
Published: March 2022

The metal–air battery (MAB) has been a promising technology to store energy, with its outstanding energy density, as well as safety features. Yet, the current material used as air cathode is costly and not easily available. This study investigated a few biomass wastes with good potential, including the oil palm empty fruit bunch and garlic peel, as well as the oil palm frond, to determine a sufficiently environmentally-safe, yet efficient, precursor to produce carbon material as an electro-catalyst for MAB. The precursors were carbonized at different temperatures (450, 600, and 700 °C) and time (30, 45, and 60 min) followed by chemical (KOH) activation to synthesize the carbon material. The synthesized materials were subsequently studied through chemical, as well as physical characterization. It was found that PF presented superior tunability that can improve electrical conductivity, due to its ability to produce amorphous carbon particles with a smaller size, consisting of hierarchical porous structure, along with a higher specific surface area of up to 777.62 m2g−1, when carbonized at 600 °C for 60 min. This paper identified that PF has the potential as a sustainable and cost-efficient alternative to carbon nanotube (CNT) as an electro-catalyst for energy storage application, such as MAB.
Should I Stay or Can I Go? Accessible Tourism and Mountain Huts in Gran Paradiso National Park
Authors: Beltramo Riccardo , Duglio Stefano , Cappelletti Giulio Mario
Published: March 2022

Within the tourism sector, sustainability has been studied widely at different levels and with different lenses. In the last few years, many research activities have been carried out to assess the social dimension of tourism. Under this perspective, scholars have focused on the accessibility of the tourism and hospitality sectors. This study represents the first-ever attempt to assess how tourists’ physical handicaps or special needs are considered in a very specific kind of accommodation facility: the mountain hut. To do so, semi-structured interviews were conducted with mountain hut managers about four mountain huts—29% of all the mountain huts located in Gran Paradiso National Park, the first established Italian protected area. The results underline both strong and critical points. Considering that many mountain huts are located in severe environments (e.g., medium-high altitudes and reachable only on foot), they have limitations in hosting visitors with physical constraints, who, on the other hand, normally do not attend this kind of facility. By contrast, all of the mountain hut managers were able to satisfy visitors with special food needs, for example, vegetarian, vegan or gluten-free, showing their capability to cope with new forms of tourism demands and expectations.
An Eccentric Binary Blackhole in Post-Newtonian Theory
Authors: Chowdhury Sourav Roy , Khlopov Maxim
Published: March 2022

Gravitational waves radiated during binary black hole coalescence are a perfect probe for studying the characteristics of strong gravity. Advanced techniques for creating numerical relativity substitute models for eccentric binary black hole systems are presumed to be crucial in existing and anticipated gravitational wave detectors. The imprint on the observation data of the gravitational wave emitted by the binary coalescence enhances two-body system studies. The aim of this study is to present an overview of the change in characteristic behaviors of hierarchical massive astrophysical objects merger, which are the databank of the early universe. We present results from numerical relativity simulations of an equal-mass and unequal mass nonspinning inspiral binary-black-hole system in the Post-Newtonian framework. We also consider the time evolution of eccentricity for an initial eccentric system. The eccentric Post-Newtonian equations are expanded in the form of the frequency related variable x=(Mω)2/3. The model is restricted to the (2, 2) spin-weighted spherical harmonic modes. We conclude that for higher eccentricity as well as mass ratio, there is higher oscillation in orbital radius and in eccentricity.
Some Results in the Theory of a Cosserat Thermoelastic Body with Microtemperatures and Inner Structure
Authors: Marin Marin , Vlase Sorin , Craciun Eduard M. , Pop Nicolae , Tuns Ioan
Published: March 2022

This study is concerned with the theory of Cosserat thermoelastic media, whose micro-particles possess microtemperatures. The mixed initial boundary value problem considered in this context is transformed in a temporally evolutionary equation on a Hilbert space. Using some results from the theory of semigroups, the existence and uniqueness of solution is proved. In the same manner, it approached the continuous dependence of the solution upon initial data and loads. From what we have studied, neither on the internet nor in the databases, we have not found qualitative issues addressed regarding the mixed problem in the context of the theory of thermoelasticity of Cosserat environments, in which the contribution of inner structure and microtemperatures are taken into account.
Eventual Positivity of a Class of Double Star-like Sign Patterns
Authors: Yu Ber-Lin , Li Zhongshan , Mou Gu-Fang , Xu Sanzhang
Published: March 2022

Identifying and classifying the potentially eventually positive sign patterns and the potentially eventually exponentially positive sign patterns of orders greater than 3 have been raised as two open problems since 2010. In this article, we investigate the potential eventual positivity of the class of double star-like sign patterns S(n,m,1) whose underlying graph G(S(n,m,1)) is obtained from the underlying graph G(S(n,m)) of the (n+m)-by-(n+m) double star sign patterns S(n,m) by adding an additional vertex adjacent to the two center vertices and removing the edge between the center vertices. We firstly establish some necessary conditions for a double star-like sign pattern to be potentially eventually positive, and then identify all the minimal potentially eventually positive double star-like sign patterns. Secondly, we classify all the potentially eventually positive sign patterns in the class of double star-like sign patterns S(n,m,1). Finally, as an application of our results about the potentially eventually positive double star-like sign patterns, we identify all the minimal potentially eventually exponentially positive sign patterns and characterize all the potentially eventually exponentially positive sign patterns in the class of double star-like sign patterns S(n,m,1).
Complete Synchronization and Partial Anti-Synchronization of Complex Lü Chaotic Systems by the UDE-Based Control Method
Authors: Wang Zuoxun , Song Cong , Yan An , Wang Guijuan
Published: March 2022

The presence of uncertainty and disturbance can lead to asymmetric control of nonlinear systems, and this asymmetric control can lead to a decrease in the productivity of the engineered system. In order to improve the control speed of the improved nonlinear system, complete synchronization and partial anti-synchronization of complex Lü chaotic systems with uncertainty and disturbance are investigated in the present paper. First, a new UDE-based dynamic feedback control method is proposed for the complete synchronization problem of the system. The method unites the dynamic gain feedback control method and the uncertainty and perturbation estimator (UDE) control method, where the dynamic gain feedback controller is used to achieve asymptotic stability of the nominal system and the UDE controller is used to handle a given controlled system with uncertainty and disturbance. Second, for the partial desynchronization problem of this system, a new UDE-based linear-like feedback control method is proposed, which consists of two controllers: a linear-like feedback controller used to achieve the asymptotic stabilization of the nominal system and the other UDE controller is designed to handle the given controlled system with uncertainty and disturbance. Finally, numerical simulations are performed to verify the correctness and stability of the theoretical results.
Neutron Stars with Baryon Number Violation, Probing Dark Sectors
Authors: Berryman Jeffrey M. , Gardner Susan , Zakeri Mohammadreza
Published: March 2022

The neutron lifetime anomaly has been used to motivate the introduction of new physics with hidden-sector particles coupled to baryon number, and on which neutron stars provide powerful constraints. Although the neutron lifetime anomaly may eventually prove to be of mundane origin, we use it as motivation for a broader review of the ways that baryon number violation, be it real or apparent, and dark sectors can intertwine and how neutron star observables, both present and future, can constrain them.
Changes in Magnetic Resonance Signal Fluctuation in Superior Sagittal Sinus: Deterioration of Arteriolar Vasomotor Function of Young Smokers
Authors: Tang Minghui , Kubota Masaya , Nitanda Yusuke , Yamamoto Toru
Published: March 2022

(1) Cerebral arteriolar vasomotor function is vital for brain health and has been examined through CO2 inhalation or breath-holding, which are both challenging for patients. We have developed a non-invasive method to evaluate this function with magnetic resonance imaging (MRI) by utilizing respiration-induced natural changes in partial pressure of arterial CO2 (PaCO2). In this study, we applied this method for 20s to evaluate the chronic effect of a few years smoking on the cerebral arteriolar vasomotor function. (2) A single slice (five slice thicknesses: 15 mm to 7 mm) perpendicular to the superior sagittal sinus of was imaged successively for 45 s using spin-echo echo-planar imaging by 3T MRI for ten smokers (24.5 ± 1.6 years) and ten non-smokers (24.3 ± 1.4 years), respectively. The venous oxygenation fluctuation (ΔYr) caused by the respiration-induced changes of PaCO2, which reflects the arteriolar vasomotor function, was calculated from the time series MR signal changes of superior sagittal sinus. (3) The ΔYr values of the smokers (0.7 ± 0.6) were significantly lower than those of the non-smokers (1.3 ± 0.8) (p = 0.04). (4) Degeneration of the cerebral arteriolar vasomotor function due to chronic smoking (even after 20s) was demonstrated by our non-invasive MRI-based method.
Ecological Assessment, Spatial Analysis, and Potential Sources of Heavy Metals (HMs) in Soils with High Background Values in the Lead-Zinc Mine, Hezhang County, Southwestern China
Authors: Zhang Fugui , Wang Chengwen , Cheng Xiaomeng , Ma Honghong , He Ling
Published: March 2022

The heavy metals (HMs) usually have high natural background levels in lead-zinc mines. Strengthening the ecological risk assessment and accurate identification sources of HMs is an important component of land resource utilization and food security. A total of 795 soil samples (with a depth of 0~20 cm) were collected in Hezhang County, an area of typical high background levels of HMs with more than 18 large lead-zinc deposits. In this study, inductively coupled plasma emission spectrometry (ICP-OES), inductively coupled plasma mass spectrometry (ICP-MS), atomic fluorescence spectrometry (AFS), and the potentiometric method (POT) were used to test the total concentration of HMs and pH values. The geographic information system was used to model the concentration distribution of HMs, and the ecological risk was assessed according to the source analysis results. The results suggest that: (1) the mean concentration of As, Cd, Cr, Cu, Hg, Ni, Pb, and Zn were 24.55, 2.25, 176.4, 89.6, 0.19, 64.2, 102, and 257 mg·kg−1, respectively, which exceeded the average background value of soils in Guizhou Province by 1.23, 3.41, 1.84, 2.80, 1.73, 1.64, 2.90, and 2.58 times, respectively, and the average concentrations of Cd, Cr, Cu, Ni, Pb and Zn exceed the screening values specified in soil contamination risk in agricultural land; (2) the results of enrichment factor (EF) showed that 29.73% of Cd are moderately polluted, and other HMs were slightly polluted in a small area or near the baseline value (EF ≈ 1); and (3) PMF analysis showed that there are five main sources, pyrite, lead-zinc ore, basalt, carbonate rock, and agricultural production, with the risk contribution ratios of 5.25%, 27.37%, 28.94%, 17.91%, and 20.53%, respectively.
Application of the British Columbia MetPortal for Estimation of Probable Maximum Precipitation and Probable Maximum Flood for a Coastal Watershed
Authors: King Leanna M. , Micovic Zoran
Published: March 2022

Estimation of the Probable Maximum Precipitation (PMP) and Probable Maximum Flood (PMF) are regulatory requirements in many jurisdictions that are used in the design of dams and assessment of existing infrastructure. The recently available British Columbia MetPortal provides regionally consistent PMP and precipitation frequency estimates across the province of British Columbia (BC). This paper proposes an approach to process and apply this data for the estimation of the PMF for watersheds across British Columbia. Guidelines are presented for selection of transposition points applicable to a watershed, and algorithms are developed for processing the geospatial probable maximum storm and precipitation frequency data. The algorithms developed are generic to multiple software and programming environments, and could also be applied in other regions where spatially and temporally intact PMP estimates are available. A detailed description of data sources and development of PMF scenario inputs is provided, as well as details of important sensitivity analyses. The methodology is applied to estimate the PMF for the Cheakamus Basin north of Squamish British Columbia. The application of the MetPortal PMP and precipitation frequency estimates, when used with a consistent PMF development methodology as proposed in this paper, will help improve the consistency of PMF estimates for watersheds across the province, offering a welcome improvement for dam owners and regulators.