bluuebunny/crossref_metadata_2025 huggingface dataset:
Increasing Efficiency in the Field Water Re-injection during Mature Hydrocarbon Reservoirs Water-Flooding, Case Study from the Sava Depression, Northern Croatia
Authors: Malvić Tomislav , Ivšinović Josip , Velić Josipa , Sremac Jasenka , Barudžija Uroš
Published: December 2019

Here is analysed the process of water re-injection in the two hydrocarbon reservoirs/fields in the Upper Miocene sandstone reservoirs, located in the western part of the Sava Depression (Croatia). Namely, those are the "A" field with "L" reservoir and the "B" field with "K" reservoir. Both currently produce hydrocarbons using a secondary recovery method, i.e. water injection (in fact re-injection of the field waters). Three regional reservoir variables had been analysed, namely porosity, permeability and injected water volumes. The number of data was small in all three cases. For porosity: reservoir “L” included 25 data, reservoir “K” 19 data; for permeability: reservoir “L” 10 data, reservoir “K” 18 data; for injected volumes of water: reservoir “L” 10 data; reservoir “K” 3 data. It defined selection of mapping algorithms mostly designed for small datasets (less than 20 points), i.e. Inverse Distance Weighting, Nearest and Natural Neighbourhood. Additionally, the Ordinary Kriging was used, but only with jack-knifed variograms, producing many “artificial points”. Results are extensively tested, using cross-validation and shape recognitions, and the Inverse Distance Weighting method is described as the most appropriate approach for mapping permeability and injected volumes in both reservoirs (“K” and “L”). The Kriging could be slightly outlined as the best approach for porosity. Obtained maps made possible application of the modified geological probability calculation as tools for prediction of successfulness of future injection (probability of 0.56). Consequently, results made possible to plan future injection more efficiently, with smaller injected volumes and same of higher hydrocarbon recovery. That could prevent useless injection, decrease number of injection wells, and save energy and funds invested in such processes.
STRATEGI MEWUJUDKAN LAYANAN PRIMA DI PERPUSTAKAAN IAIN PONOROGO
Authors: Mujiati Mujiati
Published: December 2019

Layanan prima menjadi salah satu hal yang harus diwujudkan oleh perpustakaan agar pengunjung memperoleh kenyamanan dan dapat mengambil manfaat dari keberadaan perpustakaan. Artikel ini memaparkan bagaimana kondisi perpustakaan STAIN Ponorogo setelah upaya pelayanan prima dilakukan utamanya pada peralihan status dari STAIN menjadi IAIN Ponorogo. Dari hasil penelitian ditemukan bahwa perpustakaan IAIN Ponorogo telah melakukan berbagai macam upaya yakni: strategi menyediakan koleksi buku yang lengkap, layanan mandiri peminjaman kunci dengan tiga komputer, memberikan attention yang lebih, memberikan pelatihan/training ORS (Online Research Skill) setiap hari jum’at, selving setiap hari dengan bantuan Office Boy, penghitungan denda dengan otomasi komputer, pelayanan kartu kunjung, kartu sakti dan layanan silang antar perpustakaan, penyimpanan barang di loker dan penggunaan cctv, request buku baru, penelusuran buku dengan menggunakan komputer OPAC, dan ketepatan jam buka layanan, serta memberikan layanan yang ramah dan cepat. Meskipun demikian masih terdapat kekurangan dalam pelayanan yakni layanan yang ramah dan cepat tersebut belum konsisten. [Excellent service is one of the things that must be realized by the library so that visitors get comfort and can take the advantage of the library existence. This article describes how the condition of the STAIN Ponorogo library after the efforts of excellent service is carried out primarily on the transition of status from STAIN to IAIN Ponorogo. The results of the study shows that IAIN Ponorogo library has made various efforts namely: a strategy of providing a complete collection of books, key lending independent services with three computers, giving more attention, providing training/ORS (Online Research Skill) training every Friday , arranging the book (selving) every day with the help of Office Boy, calculating fines with computer automation, visiting card services, magic cards and cross services between libraries, storing goods in lockers and using cctv, request for the new books, searching books using OPAC computers, and accuracy in opening hours service, as well as providing friendly and fast service. Nonetheless is still lacking of friendly and fast service].
Sex Differences of the Brain Structural Adaptation to Hypoxic Environment
Authors: Fan Cunxiu , Zhao Cunhua , Zhao Yuhua , Yin Wu , Lin Jianzhong , Zhang Jiaxing
Published: December 2019

Background: Different physiological and pathological patterns have been found in the two sexes at high altitude. However, sex differences in brains remain unknown.
Methods: T1-weighted MRI scanned in 61 Tibetan males and 68 Tibetan females aged 17-23, and Freesurfer was used to detect brain structures. Neuropsychological tests were also performed. Matched lowland Han subjects were controls.
Results: Both Tibetan and Han males had larger global gray matter (GM) volume and white matter volume than females, while Tibetan but not Han female brains contained a larger proportion of GM than male brains. Tibetan females had significant smaller regional GM volume in the left rostral middle frontal gyrus, pars opercularis, and right caudal middle frontal gyrus, and moreover, GM volume in the left pars opercularis positively correlated with digit span score. However, Tibetans females had significantly thicker cortices in the left rostral middle frontal gyrus, left pars triangularis, right rostral middle frontal gyrus, and right pars triangularis than males and cortical thickness in these regions negatively correlated with altitude. In Tibetan females but not males, the negative correlation of cortical thickness with altitude has been testified by global analysis. Conversely, Han subjects showed discrepant sex differences in brains with Tibetans, showing larger regional GM volume and thicker cortices in different brain areas.
Conclusion: A distinct pattern of sex differences exists between Tibetan and Han brains. Female brains may be more tolerable to hypoxia. Sex differences in the brains of Tibetans may be related to different neuropsychiatric performances in the two sexes.
Prevalence and associated factors of cervical cancer among women in Ethiopia: A systematic review and meta-analysis
Authors: Asrat Dereje Zena , Feleke Berhanu Elfu , Mihretie Kebadnew Mulatu
Published: December 2019

Background: cervical cancer is the second commonest disease of women in Ethiopia. Even though, some studies were conducted to assess the prevalence and associated factors of cervical cancer among women in Ethiopia, a variation in reported prevalence across the studies were observed. The aim of this study was to determine the pooled prevalence estimate and associated factors of cervical cancer among women in Ethiopia. Methodology: A systematic review and meta-analysis was performed based on published and gray literatures between 2010 and 2019. Articles were evaluated using Joanna Briggs Institute database guidelines by two independent authors. The pooled prevalence estimate was calculated using MedCalc software-version 19.0.7 and the pooled odd ratios for predictors was calculated using RevMan software version 5.3. A meta-analysis using a mantel Hansen variance random-effects model was performed to assess the amount of variation in between studies. The report was depicted descriptively using pooled estimated prevalence and odd ratios using tables and plots. Result: From 124 retrieved data, 10 full text articles were eligible for the review. The pooled prevalence estimates of cervical cancer among women in Ethiopia using random-effect model was 15.7%, 95%CI (10.8, 21.3%). Statistically significant heterogeneity between studies was detected (I 2 =94.35% (p<0.0001). Among all associated factors measured: numbers of life time sexual partners >1, OR=0.40, 95% Cl (0.21,0.27), being HIV positive, OR=0.41,95%CI(0.21,0.75), having history of STI,OR=1.99,95% CI (1.02,3.87), women getting widowed, separated or divorced), OR=0.32, 95% CI(0.14,0.75),income <1000birr, OR=1.78, 95% CI (1.19,2.65) and women had experience of contraceptive use, OR=2.32, 95% CI (1.75,3.43) were had statistical significant association with cervical cancer among women in Ethiopia Conclusion: The pooled prevalence estimate of cervical cancer among women in Ethiopia was high. There was a variation of cervical cancer reports across studies. Reporting of this information in a consistent manner is important for researchers to enhance future studies and also useful for policymakers and practitioners for better understanding of the burden of cervical cancer in Ethiopia for prevention, diagnosis, and early treatment of the disease. Trial registration: This systematic review for registration in PROSPERO was retrospectively registered on June 20,2019.
Treatment of recurrent urinary tract infections in a 60-year-old kidney transplant recipient – last-chance antibiotics and phage therapy
Authors: Rostkowska Olga Maria , Międzybrodzki Ryszard , Miszewska-Szyszkowska Dorota , Górski Andrzej , Durlik Magdalena
Published: December 2019

Background: The article underlines the problem of antimicrobial resistance in transplant departments where wide-spectrum antibiotics must often be used as first line treatment for immunocompromised patients. This applies especially to kidney transplant recipients who suffer from urinary tract infections. Additional means to control infections and support treatment methods are much needed in departments treating transplant patients. Case presentation: This article presents a case of a 60-year-old patient after kidney transplantation repeatedly admitted to the hospital due to recurrent urinary tract infections, including an episode of urosepsis, caused by Klebsiella pneumoniae producing extended-spectrum beta-lactamases (ESBL). Kidney transplantation was performed due to renal insufficiency caused by polycystic kidney disease, without removing of the patient’s own kidneys. As a consequence of numerous episodes of urinary tract infections (12 episodes within 15 months since transplantation), the patient developed chronic infection caused by ESBL-producing K. pneumoniae which showed variable susceptibility to carbapenems and full susceptibility to colistin only. In the meantime, the patient developed accompanying urinary tract infection caused by a vancomycin-resistant Enterococcus faecium and subsequent colonisation of the gastro-intestinal tract by this strain. In an attempt to curb the K. pneumoniae infection, bacteriophage therapy was applied on the experimental basis, coordinated by the Phage Therapy Unit of the Hirszfeld Institute in Wrocław, Poland. Probiotics were also used in an attempt to modify the bacterial gut colonisation. Eventually, the patient fully recovered following nephrectomy of his own left kidney in which cysts were suspected to be the reservoir of bacteria causing recurring infections. In this article we discuss some treatment methods complementary to classic antibiotic therapy, in times when antimicrobial resistance is on the rapid rise. Conclusions: It is necessary to further research methods of decreasing our reliance on antibiotics in view of falling susceptibility to those medicines. Phage therapy or altering patient’s microbiome can give us an edge in tackling infections which today are treated solely with antimicrobials. This would be of great significance to transplant departments.
A method development for improving the stability of vegetable polyphenol complexes for semi-finished minced meat products with antioxidant effect
Authors: Gerasimov A. V. , Bazhenova B. A. , Zhamsaranova S. D. , Zabalueva Yu. Yu. , Zambulaeva N. D. , Burkhanova A. D.
Published: December 2019

Polyphenolic vegetable complexes are active antioxidants and play an important role in the processes of free radicals quenching in the human body. The aim of the work was to develop an immobilization method as a way for improving the stability of polyphenols in dried cowberry squeezing extract (DCSE) and to develop semi-finished minced meat products with antioxidant effect without changing their nutritional value. Experiments were carried out to study the nutritional value of DCSE. The presence of a large number of polyphenolic compounds in DCSE and a high radical-binding ability of the extract were revealed. Based on the mathematical planning method, an offal paste composition was obtained, which was used to obtain pellets, and the formulation of semi-finished minced meat products with pellets was optimized. It was established that preliminary immobilization of DCSE on offal pellets components allows to increase the level of total antioxidant content in the minced meat. Subsequent heat treatment of semi-finished minced meat products produced from such minced meat showed an increase in stability and, thus, bioavailability of antioxidants and the possibility of obtaining a finished product with antioxidant effect. The antioxidant effect of cowberry squeezing extract in the meat system is proved: accumulation of lipid oxidative decomposition products in the meat system during storage of frozen semi-finished minced meat products was inhibited to a greater extent when using offal pellets with immobilized compounds of cowberry squeezing extract. This work was carried out as part of the State Assignment of the Ministry of Education and Science of the Russian Federation No. 19.5486.2017/BCh and the «Young Scientists of ESSTU‑2019» grant.
Zemin Analizleriyle Dinamik Davranış Özelliklerinin Belirlenmesine Yönelik Pilot Bir Çalışma: Kahramanmaraş İli Üngüt Mahallesi Örneği
Authors: CEREN Kübra , KARAKAN Eyyüb
Published: December 2019

Can ve mal kayıplarıyla maddi manevi kayıplara neden olan depremlerin, diğer doğal afetler gibi önlenmesi mümkün değildir, fakat depremlerin meydana getirebileceği hasarı en aza indirgemek mümkündür. Türkiye tektoniğinde önemli bir konuma sahip olan Kahramanmaraş ili’nin yüzölçümünün büyük çoğunluğu aktif faylara ev sahipliği yapmaktadır. Zeminlere ait mühendislik özelliklerinin belirlenmesi dinamik yükler altındaki zemin davranışlarının ve/veya meydana gelebilecek zararların en aza indirilebilmesinde büyük önem taşımaktadır. Bu nedenle Kahramanmaraş ili Üngüt Mahallesinde zemin dinamik davranış analizi yapılmıştır. Bu çalışma için Üngüt Mahallesinde yer alan 12 adet sondaj kuyusundan elde edilen veriler analizlerde kullanılmıştır. Bu çalışma kapsamında Deepsoil programı yardımıyla çalışma alanında belli noktalarda dinamik davranış analizi yapılmıştır. Çalışma alanında doğrusal, frekans alanında eşdeğer doğrusal ve zaman alanında doğrusal olmayan analizler yapılarak zeminin dinamik davranışı hakkında bilgi edinilmiştir. Seçilen alanın zeminin dinamik davranış analizi 17 Ağustos 1999 Kocaeli (Mw=7.4) depreminin ivme kayıtları kullanılarak gerçekleştirilmiştir. Yapılan analizler sonucunda çalışma alanına ait ivme, tepki spektrumu ve amplifikasyon faktörü grafikleri elde edilmiştir. Bu çalışmada, analiz sonuçlarından elde edilen veriler değerlendirilerek, araştırmaya konu olan bölgedeki mevcut ve yeni yapılacak binaların temel zeminlerinin dinamik davranışlarının belirlenmesi hedeflenmiştir.
La operacionalización de las competencias digitales en la literatura
Authors: Acosta Silva David Arturo
Published: December 2019

Las investigaciones sobre las competencias digitales de los jóvenes han reportado resultados discordantes. Es posible que ello sea ocasionado por la diversidad de posturas teóricas que fundamentan dichos estudios. Lo anterior implica la necesidad continuar con la revisión del constructo de competencias digitales. Un camino para lo anterior es el análisis de su operacionalización. Por tanto, se realizó una metasíntesis de 50 estudios que han explorado las competencias digitales empíricamente. Nuestros resultados indican algunos problemas en la operacionalización, por lo que se concluye la necesidad continuar mejorándola, lo cual permita generar propuestas más comprensivas de competencias y se reduzcan imprecisiones.
Arsenic removal by the micellar-enhanced ultrafiltration using response surface methodology
Authors: Gokcek Oznur Begum , Uzal Nigmet
Published: December 2019

The present research investigates the removal of arsenic (As) from aqueous solutions using micellar-enhanced ultrafiltration (MEUF) by utilizing two different surfactants: benzethonium chloride and dodecyl pyridinium chloride (BCl and DPCl). The impact of the operating variables and maximum removal efficiency were found under different conditions for BCl and DPCl surfactants. The maximum As rejection efficiency for MEUF with BCl and DPCl surfactants is 92.8% and 84.1%, respectively. In addition to this, a statistics-based experimental design with response surface methodology was used for the purpose of examining the impact of operating conditions, including initial pH, initial As concentration (ppb), and surfactant concentration (BCl, mM) in As-removal from aqueous solutions. In the analysis of the experimental data, a second-order polynomial model that was validated by statistical analysis for the BCl surfactant was used. On the basis of the response model created, the removal of As ions was acquired at optimum operating parameters, including the initial As concentration of 150 ppb, surfactant concentration of 5 mM and pH 10 for the BCl surfactant with 92.8% As-removal efficiency.
Integrated surface and groundwater resources allocation simulation to evaluate effective factors on greenhouse gases production
Authors: Majedi Hamidreza , Fathian Hossein , Nikbakht-Shahbazi Alireza , Zohrabi Narges
Published: December 2019

The water resources management in the developing countries calls for the adoption of the systems approach in accordance with the regulations of the Kyoto Protocol (1997) clean development mechanism. In this research, integrated modeling was carried out under multipurpose scenarios using six reservoir dams with a capacity of 10,500 MW (megawatt) to reduce the greenhouse gas productions. The simulation and development of the integrated water evaluation and planning (WEAP) model within a 50-year period, along with the development of the MODFLOW model in alluvial deposits that interacts with the river, allowed for the analysis of the integrated water resources management system of the Great Karun basin. Several scenarios were implemented following the calibration and validation of the linked integrated model. The components covered by these scenarios included the satisfaction of the in-basin and off-basin demands, the effect of the integrated consumption of water resources, and the effect of increased efficiency of irrigation networks with maximum clean hydroelectricity production and minimum aquifer level decline under drought-induced water shortage conditions. The second scenario, which generates 15,282 GWh (gigawatt-hour) of power, not only optimally meets the future and environmental demands as the best operating scenario but also minimizes the emission of the greenhouse gases in the basin.
Contemporary use of surgical radiofrequency ablation and coronary artery bypass in patients with long-standing, persistent atrial fibrillation and coronary heart disease
Authors: Kalybekova A. , Rahmonov S. , Chernyavskiy A. , Almazov A. , Narcissova G. , Mironenko S.
Published: December 2019

Atrial fibrillation is one of the main types of arrhythmia; it leads to deterioration in haemodynamics, a decrease in patient’s quality of life, the development of complications such as stroke, a decrease in tolerance to physical stress and ultimately death. The reported prevalence of atrial fibrillation among the general population is 0.4%–1%. The incidence of atrial fibrillation has been found to increase with age such that every 10-year increase in age doubles the incidence of this disease. The incidence of coronary heart disease also increases with age. Current studies have shown an increase in concomitant diseases such as coronary heart disease and atrial fibrillation; these pose a serious health threat and increase the risk of patient death. The present review discusses surgical methods for treating long-standing, persistent atrial fibrillation in patients with coronary heart disease based on radiofrequency and cryoablation with simultaneous coronary artery bypass grafting. The present review revealed that biatrial ablation allows achieving high levels of markers that indicate atrial fibrillation recurrence-free survival following simultaneous surgical correction of coronary heart disease in the long-term postoperative period; however, patients undergoing this procedure require permanent pacemaker implantation due to the high incidence of irreversible sinus node dysfunction caused by the exposure to additional ablation lines in the right atrium. Published articles were searched from January to July 2019 using PubMed, eLIBRARY, Elsevier and MEDLINE.
Received 9 July 2019. Revised 22 November 2019. Accepted 26 November 2019.
Funding: The study did not have sponsorship.
Conflict of interest: Authors declare no conflict of interest.
Author contributions Conception and study design: A.T. KalybekovaDrafting the article: A.T. Kalybekova, A.A. AlmazovCritical revision of the article: A.T. Kalybekova, S.S. RahmonovFinal approval of the version to be published: A.T. Kalybekova, S.S. Rahmonov, A.M. Chernyavskiy, A.A. Almazov, G.P. Narcissova, S.P. Mironenko
Removal of electrodes of implanted systems. The state of the problem
Authors: Sapelnikov O. , Kulikov A. , Cherkashin D. , Grishin I. , Nikolaeva O. , Ardus D. , Shiryaev A. , Akchurin R.
Published: December 2019

The increase in indications for cardiac implantable devices had led to an increase in the number of device implantations worldwide, with a corresponding increase in the incidence of complications. Finally, in 1980, the development of methods for removing problematic leads and devices were first attempted. Currently, an average of 10,000–15,000 extractions/year are performed worldwide. Improving the design and technical performance of device leads has been the goal of several scientific and engineering efforts; however, they occasionally continue to fail, potentially leading to adverse clinical outcomes. The preferred technique is transvenous lead extraction, and over the past few decades, its effectiveness has substantially improved. Nevertheless, the extraction procedure is associated with high risks, and these risks should be considered when deciding on the procedure. The present review discusses the issues associated with determining appropriate strategies to reduce the risks associated with lead extraction and identifying accurate indicators for the removal of cardiac implantable device leads.Received 17 May 2019. Revised 12 December 2019. Accepted 13 December 2019.Funding: The study did not have sponsorship.Conflict of interest: Authors declare no conflict of interest.
Treatment of postoperative sternomediastinitis in infants
Authors: Soynov I. , Voitov A. , Kulyabin Yu. , Ivantsov S. , Galstyan M. , Zubritskiy A. , Omelchenko A. , Arhipov A. , Gorbatykh Yu. , Leykekhman A. , Strunin O. , Bogachev-Prokophiev A.
Published: December 2019

Aim. To evaluate the results of vacuum therapy and closed irrigation drainage (CID) technique for the treatment of postoperative sternomediastinitis in infantsMethods. This single-institution retrospective study included 69 patients diagnosed with sternomediastinitis from 2008 to 2018. Patients were divided into two groups: those treated using vacuum-assisted closure therapy (VAC; n = 29) and those treated using CID (n = 40). After propensity score matching, a total of 25 infants were included in each group.Results. Age, gender, weight, body surface area, Risk Adjustment for Congenital Heart Surgery score, cardiopulmonary bypass time and the frequency of open chest management were comparable between the two groups after propensity score matching. During hospital stay, no deaths were noted in the VAC group, whereas eight patients died in the CID group (32%; P = 0.004). The median durations of mechanical ventilation were 79 (28; 176) and 154 (24; 356) hours in the VAC and CID groups, respectively (P = 0.38). Moreover, eight patients in the VAC group (32%) were extubated early (P = 0.028). Re-mediastinitis occurred in 1 (4%) and 8 (32%) patients from the VAC and CID groups, respectively (P = 0.01). The multivariable regression analysis revealed that the CID technique was the only risk factor for re-mediastinitis (odds ratio, 13.9; 95% confidence interval, 1.2–152.5; P = 0.031). The median durations of hospital stay were 14 (10; 30) and 23 (18; 33) days in the VAC and CID groups, respectively (P = 0.045).Conclusion. VAC therapy in patients with mediastinitis showed better outcomes than CID technique such as lower hospital mortality and re-mediastinitis rates.Received 14 August 2019. Revised 8 December 2019. Accepted 10 December 2019.Funding: The study did not have sponsorship.Conflict of interest: Authors declare no conflict of interest.
Combined transcatheter thrombectomy system for treatment of acute ischaemic stroke
Authors: Kretov E. , Malaev D. , Andreev M. , Trebushat D. , Grachev N. , Boykov A. , Prohorihin A. , Tarkova A. , Baystrukov V.
Published: December 2019

Background. Since 1996, thrombolytic therapy with tissue plasminogen activator has traditionally been the first-line treatment for patients with ischaemic stroke. However, the results of recent randomised trials have shown the advantage of mechanical thrombectomy over thrombolytic therapy for successful revascularisation of brain arteries and improvement of clinical outcomes. Owing to the development of endovascular surgery, mechanical thrombectomy has now become an effective and safe method for treating ischaemic stroke resulting from the occlusion of large cerebral arteries.Aim. The main aim of this study was to develop a prototype for a combined transcatheter system to be used for mechanical thrombectomy.Methods. During the implementation of the project, we first analysed the data on the problems to justify the choice of standard sizes of a stent retriever and an aspiration catheter and to determine the basic set of physical–mechanical, functional and biomedical characteristics of the system. A prototype of a combined transcatheter system for mechanical thrombectomy, which comprises an aspiration catheter and a stent retriever, was manufactured. Moreover, preclinical tests were conducted to study the physical properties of the developed prototype and assess its effectiveness. Results. Data from preclinical tests showed a level of radial stiffness of the prototype that was comparable to that of a similar device on the market, satisfactory visualisation under angiography and high efficiency while performing mechanical thrombectomy in vitro and in vivo tests.Conclusions. Studies on the prototype of the combined transcatheter system for thrombectomy have shown positive results in preclinical trials.Received 5 December 2019. Revised 18 December 2019. Accepted 20 December 2019.Funding: The study did not have sponsorship.Conflict of interest: Authors declare no conflict of interest.
The Future of Imaging in Pulmonary Hypertension: Better Assessment of Structure, Function, and Flow
Authors: Narang Akhil , Freed Benjamin H.
Published: December 2019

Cardiovascular imaging is essential in the evaluation and management of patients with pulmonary hypertension. Echocardiography and magnetic resonance imaging, in particular, provide basic measurements of pulmonary pressure and right ventricular function, but current technology allows for a much more comprehensive assessment. Many of these advancements have the potential to enhance risk stratification and provide additional phenotypic data that may strengthen or alter the therapeutic approach. This review will highlight multiple novel techniques from various imaging modalities and how this information can be applied in clinical practice.
Computational Models for Self-Interacting Proteins Prediction
Authors: Qu Jia , Zhao Yan , Zhang Li , Cai Shu-Bin , Ming Zhong , Wang Chun-Chun
Published: December 2019

:

Self-Interacting Proteins (SIPs), whose two or more copies can interact with each other,
have significant roles in cellular functions and evolution of Protein Interaction Networks (PINs).
Knowing whether a protein can act on itself is important to understand its functions. Previous
studies on SIPs have focused on their structures and functions, while their whole properties are less
emphasized. Not surprisingly, identifying SIPs is one of the most important works in biomedical
research, which will help to understanding the function and mechanism of proteins. It is worth
noting that high throughput methods can be used for SIPs prediction, but can be costly, time
consuming and challenging. Therefore, it is urgent to design computational models for the
identification of SIPs. In this review, the concept and function of SIPs were introduced in detail.
We further introduced SIPs data and some excellent computational models that have been designed
for SIPs prediction. Specially, the most existing approaches were developed based on machine
learning through carrying out different extract feature methods. Finally, we discussed several
difficult problems in developing computational models for SIPs prediction.
Main-Chain Ferrocene-Containing Polymers Prepared by Acyclic Diene Metathesis Polymerization: A Review
Authors: Sha Ye , Shen Zhihua , Jia Huan , Luo Zhenyang
Published: December 2019

Ferrocene, the crown of metallocene family, is widely studied as a functional
unit in electrochemical and catalytic applications due to its sandwich structure. Ferrocene
moieties can be embedded into the polymer backbone, leading to main-chain ferrocenecontaining
polymers. These polymeric materials combine the unique functionalities of
iron center with the processabilities of polymers. As one of the choice polymerization
techniques, acyclic diene metathesis (ADMET) polymerization serves as a versatile
method to prepare main-chain ferrocene-containing polymers under mild conditions using
α,ω-dienes as monomers. This paper overviews main-chain ferrocene-containing polymers
prepared by ADMET polymerization. Advances in the design, synthesis and applications
of this class of organometallic monomers and polymers are detailed.
Deciphering the Novel Target Genes Involved in the Epigenetics of Hepatocellular Carcinoma Using Graph Theory Approach
Authors: Roy Nimisha , Raj Utkarsh , Rai Sneha , Varadwaj Pritish K.
Published: December 2019

Background:

Even after decades of research, cancer, by and large, remains a challenge and is
one of the major causes of death worldwide. For a very long time, it was believed that cancer is simply an
outcome of changes at the genetic level but today, it has become a well-established fact that both genetics
and epigenetics work together resulting in the transformation of normal cells to cancerous cells.

Objective:

In the present scenario, researchers are focusing on targeting epigenetic machinery. The
main advantage of targeting epigenetic mechanisms is their reversibility. Thus, cells can be reprogrammed
to their normal state. Graph theory is a powerful gift of mathematics which allows us to understand
complex networks.

Methodology:

In this study, graph theory was utilized for quantitative analysis of the epigenetic network
of hepato-cellular carcinoma (HCC) and subsequently finding out the important vertices in the
network thus obtained. Secondly, this network was utilized to locate novel targets for hepato-cellular
carcinoma epigenetic therapy.

Results:

The vertices represent the genes involved in the epigenetic mechanism of HCC. Topological
parameters like clustering coefficient, eccentricity, degree, etc. have been evaluated for the assessment
of the essentiality of the node in the epigenetic network.

Conclusion:

The top ten novel epigenetic target genes involved in HCC reported in this study are
cdk6, cdk4, cdkn2a, smad7, smad3, ccnd1, e2f1, sf3b1, ctnnb1, and tgfb1.
Helenalin: An Anti-Inflammatory and Anti-Neoplastic Agent: A Review
Authors: Kriplani Priyanka , Guarve Kumar , Baghel Uttam S.
Published: December 2019

Objective:

Helenalin is a natural anti-inflammatory agent that is proving its efficacy to treat
various medical conditions. Though many plants are proving their effectiveness but their mechanisms
are still not well understood. The objective of the review is to summarize various mechanisms of helenalin
to treat inflammatory disorders and cancers, adverse effects, and avenues of further research.

Methods:

Structured research was carried out including Pub med, Science direct Medline, Research
Gate and Google Scholar to find all articles published on helenalin. Various keywords used were “helenalin”,
“Arnica”, “cancer”, “anti-inflammatory”, “cardiovascular”, “IBD”, “pharmacokinetics” etc. The
aim of the review was to find out the problem prevailing in the data published to date which will help
the researchers to investigate the molecule clinically.

Results:

Seventy articles are included in the review. Helenalin is found to cure chronic conditions like
rheumatoid arthritis, ulcers and malignancies like stomach, colon, breast, larynx, lung and skin cancers
via multiple mechanisms. These diseases do not proceed via a unilateral pathway. So, it can be a useful
molecule to treat numerous diseases.

Conclusion:

This review article will help us to systemically analyze the wealth of information concerning
the medicinal properties of helenalin and to recognize the gaps which have vetoed its pervasive application
in the medical community.
Analysis Of Vegetation Classification Algorithms On Satellite Images And Medical Images
Authors: Manju S. , Helenprabha K
Published: December 2019

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In recent days, the remote sensing algorithms are used in the medical field for improving the visualization of the medical images. Because, the medical images are generally in the gray scale image format for better visualization the colour Doppler or spectrograms are used but they are expensive. To overcome this drawback the remote sensing algorithm is applied to the medical images to group the pixels and visualize in different colours. The image processing techniques is used to classify the vegetation region into 16 samples. The image pre-processing is done by Wiener filter to remove the noise. Feature extraction is carried out by Grey Level Co-occurrence Matrix (GLCM) and the spectral bands are optimized by Particle Swarm Optimization (PSO) .The classification of vegetation region is classified by Extreme Learning Machine. In this, the comparisons of the remote sensing algorithms like IRVM-MFO, ELM-DF and ELM-PSO for the Indian pines and Salinas Dataset. Among these the ELM- Dragon Fly algorithm produced the best results for both the sets. Hence, this ELM-DF is applied to the Brain tissue region segmentation. In this paper the analysis is performed to find the efficient method for vegetation classification by comparing with other methods. Simulations are carried out on two datasets such as Indian Pine and Salinas scene. Performance metrics such as accuracy, specificity, and sensitivity have been evaluated that show the efficiency of the proposed classifier.
Primary Hypothyroidism in Adults Based on Jorjani's View Point of the Book “Zakhire Kharazmshahi”
Authors: Ebrahimpour Naser , Khazaneha Mahdieyh , Tajadini Haleh
Published: December 2019

Objective:

The prevalence of primary hypothyroidism is increasing in adults (PHTA), and the reduction in the threshold for treatment and also the requirement to increase drug usage are major problems in approaching this disorder. Persian Medicine (PM) looks from a different view on etiology of diseases. Therefore, we tried to present the etiologies of PHTA according to an important book of PM i.e. “Zakhire Kharazmshahi”.

Method:

At first, the common symptoms and signs of PHTA were identified by investigating the Medline, Scopus, and Cochrane databases and their Persian equivalents were extracted from PM sources. These synonyms were searched as keywords in the book and the primary causes that were mentioned in association with the signs and symptoms were extracted. Then, we explained the total etiologies that were discussed for the occurrence of the causes, with respect to the principles of health care in PM.

Results:

"Cold distemperament", an increase in "Phlegmatic Humor ", an increase in "Melancholic Humor" and "Emtela" (repletion) were recognized as four main causes of PHTA. According to the book, the most important etiologies of these conditions are insufficient exercise, overeating, food intake before total stomach emptying and excessive amounts of cold temperament substances (foods, herbs, seeds, spices, etc.) in daily diet.

Conclusion:

From the viewpoint of PM, lifestyle spatially eating habits and physical activity play important causative roles in occurring and prognosis of PHTA. Hence, it is recommended to assess these results by more observations and clinical studies.
Controlled Parenteral Formulations: An Efficacious and Favourable Way to Deliver the Anti-psychotic Drugs
Authors: Gupta Harshita , Panchal Rutu , Acharya Niyati , Mehta Priti Jignesh
Published: December 2019

The current paradigm of pharmaceutical formulations is focused on the controlled &
sustained delivery of a drug for the management of chronic impairments. Since these diseases need
daily and multiple intakes of the drug (i.e., twice or thrice a day) and missing a single dose, leads to
the poor therapeutic window which governs unpleasant pharmacological response and ultimately
patient in-compliance. All over the world, millions of patients are suffering from life-threatening
diseases; one of which is “psychosis”, which immensely requires prolong and sustain release of the
drug. Moreover, mainstay lacuna with antipsychotic medication is the reoccurrence of the symptoms,
and patient adherence on the therapy has been observed. These issues attract scientists to formulate
the Controlled Parenteral Antipsychotic (CPA). As per the literature search, significant work
has been performed on the development of Novel Controlled Parenteral Formulations (CPFs) for the
treatment of psychosis and especially focus has been given to microsphere, esterification, nanoformulation,
and salt-based formulation. Reports revealed that all of the above-mentioned formulations
have shown enormous potential to enhance the duration of a drug in the body for a longer period in a
controlled manner. The development of a drug in any form has shown a great impact on the patient’s
life, with tremendous productivity in the Pharma Market. As well as, this has raised the hope to get
more efficacious results of both the categories i.e., typical & atypical antipsychotics and limiting the
drawbacks of conventional antipsychotic drug delivery. Controlled formulations have also shown
the prominent solutions to handle one of the major obstacles that arises due to the Biopharmaceutical
Classification System (BCS). Drugs belonging to any of the BCS class can be utilized now with the
idea of CPF. In this context, the current paper relies on CPA’s strengths, weaknesses, opportunities,
and challenges followed by a compilation of attempt made by scientists on its formulations (microspheres,
salt-based, and nanoformulation) which will be one-stop-shop for the researchers working
globally in this field to make better improvement on the existing options for psychosis. In summary,
this review explains the concept of CPA as a promising option to treat psychosis.
Geografía de la intensidad del conocimiento y desigualdad social en los municipios hidalguenses
Authors: Pérez Hernández Carla Carolina , Salazar Hernández Blanca Cecilia , Hernández Calzada Martín Aubert
Published: December 2019

El objetivo de este trabajo es calcular el Índice de Intensidad de Conocimiento (IC) de los municipios hidalguenses con base en la estructura productiva de los sectores económicos. Para tal propósito, se desarrolló un análisis bajo el método de reflexiones y se recopiló la información de fuentes públicas. Los resultados muestran que el estado de Hidalgo cuenta con diferentes niveles de diversidad y ubicuidad, por lo que se recomienda considerar la geografía de la intensidad de conocimiento en relación con la desigualdad social de los municipios para la formulación de políticas diferenciadas acordes a los distintos contextos locales.
THE NEO-FOLKLORE STYLE IN A ROTARU’S TRIO FOR VIOLIN, PIANO AND CELLO “INO-2”.
Authors: DJALİLOVA Natalia
Published: December 2019

The piano Trio, the study of which is part of the dissertation research:” The features of the performance of the piano part in a cycle of three piano Trio “INO”, is discussed in this article.
The piano Trio, its meaning in the work of the author, the main stylistic, harmonic and rhythmic aspects are analyzed in this article. The connection with the neo-folklore trend in music and traditional genres in Moldavian folk music, the synthesis of traditional folklore with modern compositional techniques are revealed.
This article is intended to determine primarily the style features of this composition. It is aimed at analyzing the characteristic features of the neo-folklore direction, which is a paramount importance in composer’s creativity.
The Trio “INO-2” was created by the composer in 2004 based on the material of “Sonata for violin and piano”, dedicated to daughter Elizabeth. The Trio consists of two parts unequal in volume, Recitativ and Allegro scherzando. The second part is the dramatic and dynamic center of the work, the first performs a kind of prologue to it.
The neo-folklorism style manifests itself in both parts of the trio. In the first part lexemes of folk genres of doina and ballads are found. This can be seen in the stanza form (5 stanza + Coda), in the rhythm rich in melismatics, in variation intonational tunes.
The modern technique of compositional writing is manifested in the appeal to the untacted rhythmic system characteristic of modern music of the late 20th and early 21st centures.
The neo-folkloric style of the second part is accented by V. Rotaru in a generalized imitation of folkloric male dances, the clear sign of which is asymmetric and unequal rhythm. It includes a sequence of seven eights, two eights, six eights, four eights. Also manifests itself in the characteristics formula of a bass chord or in virtuosic passages sixteenth. The author’s appeal to imitation of a cymbal texture, which is most often performed in the piano part, should also be noted.
The style of neo-folklorism in this composition harmoniously combines with both classical ensemble texture and innovative techniques of writing technique. In both cases, a variety of polyphonic techniques for combining piano and string instruments is playing an important role.
“INO-2” received well-deserved recognition in the interpretation of professional performers – Inna Saulova, Nadezhda Kozlova and Olga Uhno – to whom it is dedicated.
Trio “INO-2” is a bright composition with imaginative contrasts, demanded in concert and teaching practice in Moldova and abroad.
In the article, in the context of development, the neo-folklore direction, which is one of the most bright style trends in Russian music of the second part of the 20th century, is studied.
Propuesta de formación del maestro-mediador para la consolidación de la cultura de paz en Colombia
Authors: Restrepo Mesa Karol
Published: December 2019

Este artículo de investigación analiza la relación entre Educación para la Paz (EpP), Pedagogía de la Memoria y Comunicación, como elementos de la formación del maestro, que facilitan la consolidación de una cultura de paz en el marco del posacuerdo, en Colombia. Adicionalmente, analiza la injerencia de los modelos pedagógicos a la luz de los procesos de construcción de paz, en el contexto colombiano. Y, por último, sugiere una propuesta temática a los programas de formación de maestros, en la búsqueda de formar sujetos que hicieran del acto educativo un proceso lleno de sentido, para que garantizaran a sus estudiantes aprendizajes significativos desde la experiencia. Así, el maestro se convertirá en estratega, al tomar el rol de mediador para construir puentes de intersubjetividad que permitieran el diálogo y la convivencia, proceso que servirá de punto de partida para reflexiones que desemboquen en modelos de formación continuada de maestros y políticas educativas futuras, con miras a alcanzar una paz sostenible y un país más equitativo.
El debate Currie-Daza y la institucionalización de la enseñanza de la economía en la Universidad Nacional de Colombia
Authors: Chaparro Germán Raúl
Published: December 2019

El proceso de institucionalización de los programas de economía en el país implica, entre otras cosas, definir su organización administrativa, establecer objetos de estudio y justificar su pertinencia. Este artículo tiene como objeto analizar el proceso de institucionalización de la enseñanza de la economía como programa académico de pregrado al interior de la Universidad Nacional de Colombia y, a partir del debate entre dos importantes directivos de los programas, a principios de los años sesenta del siglo XX, ellos son Álvaro Daza Roa y Lauchlin Currie, quienes defendieron dos visiones distintas, y prácticamente antagónicas, de la economía. El primero se refiere a la economía como un mecanismo que debe ser estudiado cuantitativamente y cuyo propósito es la ganancia privada; Currie, por su parte, concibe la economía como un organismo, que amerita un estudio principalmente cualitativo y que debe estar orientado a mejorar el bienestar material de la comunidad. Se espera que el documento contribuya a entender la importancia histórica de los debates en torno a la enseñanza de la economía.
Análisis econométrico del comportamiento del desempleo en el Ecuador (segundo trimestre 2007 a cuarto trimestre 2017)
Authors: Molero Oliva Leobaldo Enrique , Salcedo Muñoz Virgilio Eduardo , Campuzano Vásquez John Alexander , Bejarano Copo Holger Fabrizzio
Published: December 2019

El objetivo de este trabajo consiste en brindar un análisis econométrico del comportamiento del desempleo en el Ecuador entre el segundo trimestre del 2007 al cuarto trimestre del 2017. El trabajo emplea la Ley de Okun como enfoque teórico para explicar el comportamiento de la tasa de desempleo. La metodología consistió en una estrategia empírica soportada en los modelos de rezagos distribuidos autorregresivos con cointegración según el enfoque de Pesaran y Shin. Los resultados encontrados sugieren que en promedio por cada 1% de crecimiento del producto hay una disminución contemporánea de la tasa de desempleo de 0,30 puntos porcentuales, pero también hay efectos que perduran en los siguientes trimestres. Se concluye que la reducción de la tasa de desempleo en el Ecuador implica un esfuerzo político y de diseño de instituciones en las relaciones laborales entre trabajadores y empresarios para dinamizar el mercado laboral.
Análisis teórico de los mitos financieros del emprendimiento
Authors: Socorro Márquez Félix Oscar , Santa Álvarez Gloria Liliana
Published: December 2019

Luego de revisar literatura relacionada, fue posible documentar cinco mitos financieros asociados con el emprendimiento, esto se hizo tomando en cuenta la postura de varios autores expertos en estos temas y otras fuentes de información disponibles, lo que permitió,  bajo una visión académica y crítica, aportar un contenido de interés para quienes desean hacer uso de esta herramienta y consideran que poseen debilidades conceptuales o carecen de información vital para garantizar la salud financiera de su emprendimiento.