bluuebunny/crossref_metadata_2025 huggingface dataset:
Rolling Bearing Fault Diagnosis Based on MFDFA-SPS and ELM
Authors: Yang Yunfan , Xi Caiping
Published: July 2022

Rolling bearings, as important parts on supporting rotating shafts, frequently suffer from fatigue failures. If these rolling bearing failures are not found in time, it will have a huge impact on the whole mechanical system’s operating safety and operating life. To improve the diagnosis of different faults as well as different degrees of faults, a fault diagnosis method based on the multifractal detrended fluctuation analysis (MFDFA) method-singularity power spectrum (SPS) with extreme learning machine (ELM) is proposed. First, MFDFA and SPS analyses are performed on vibration acceleration signals with different faults and different degrees of damage under the same operating conditions, the spectral parameters of stability and quantitative description of differentiation are selected for feature extraction, and then the selected six feature parameters are put into the extreme learning machine for fault classification. The effectiveness of the MFDFA-SPS feature extraction method is demonstrated by analyzing and testing the measured bearing signals. The fault diagnosis accuracy of the bearing fault signals can reach 99.2% based on the MFDFA-SPS with ELM method by using the Case Western Reserve database. The improvements are 6.79% and 18.42% compared to the fault diagnosis methods based on MFDFA with ELM and SPS with ELM. Compared with the methods based on MFDFA-SPS with LSSVM classifier and SVM classifier, the accuracy improvements are 3.54% and 4.25%, respectively. The results show that the method proposed in this paper can achieve the diagnosis of bearing faults and the method based on MFDFA-SPS with ELM is more efficient than the methods based on MFDFA-SPS with LSSVM and SVM classifiers, which is suitable for practical engineering problem-solving.
Entropy-Based Fuzzy TOPSIS Method for Investment Decision Optimization of Large-Scale Projects
Authors: Cao Junli , Xu Fangfang
Published: July 2022

Investment of large-scale projects must consider various factors, such as economic conditions and investment environment when making decisions. In large-scale project investment problems, almost 90% of them are completed in a multiobjective context. To this end, the authors of this paper have proposed an entropy-based fuzzy TOPSIS synthesis method to assist in the decision-making optimization of large-scale project investment. Firstly, in accordance with the background of the development of multiattribute decision-making method (MADM), closely related to large-scale project investment, the related research works were studied, and the relevant methods are sorted out. Then, the improved vague-entropy-weight based fuzzy TOPSIS (VEWF-TOPSIS) method, entropy and interval language intuitionistic fuzzy sets based TOPSIS (EILIF-TOPSIS) method, and information entropy attribute importance based intuitionistic fuzzy TOPSIS (IEAI-IF-TOPSIS) method were introduced, and a synthesis MADM method that comprehensively combines the above three methods was proposed. Finally, a numerical case was constructed to properly show the effectiveness of the method proposed in the present work, and the conclusions were put forward for providing ideas and methods for large-scale project investment decision-making. It is of great significance that the proposed framework would make large-scale project investment decisions more reasonable and practical, which enriches the research methods of MADM problems to a certain extent and can provide reference for the actual large-scale project investment decision-making problems.
Efficacy and Safety of Apatinib plus Neoadjuvant Chemotherapy for Locally Advanced Esophageal Squamous Cancer: A Phase II Trial
Authors: Yang Bo , Guo Xiaofeng , Le Cheng , Su Wenzhong , Li Xiaoming , Zhang Yanfeng , Yang Guangyi , Liang Weimin , Zheng Zhixin , Wu Junpeng , Zhang Yaowen , Hao Anlin
Published: July 2022

Evidence for neoadjuvant chemotherapy combined with targeted therapy for locally advanced esophageal squamous cancer (ESCC) is inadequate. We conducted a single‐arm phase II trial to evaluate the efficacy and safety of apatinib combined with taxol and cisplatin (ATP) for locally advanced ESCC. All patients were cT3‐4aN0‐3 M0 (IIIb‐IVa) stage, which were confirmed by histopathology. Apatinib was taken orally (425 mg/d) for two cycles, followed by one cycle of rest. Taxol was administered at 135 mg/m2 intravenously on day 1, and cisplatin was administered at 20 mg/m2 intravenously on day 1 to day 3. Radical ESCC resection was performed 4 weeks after ATP. The primary endpoint was pathological response rate (pCR). Secondary endpoints were pathologic response rate (MPR), disease‐free survival (DFS), overall survival (OS), R0 resection rate, and safety profile. This trial was registered. We evaluated 41 patients for screening from Oct 2018 to July 2020, of whom 39 were enrolled in the study, with a median age of 65 years (range 49‐75 years), and 29 (74.4%) were male. Among the 39 patients, 1 was considered unresectable by the multidisciplinary team due to tumor progression, and 38 patients underwent surgery eventually. The median follow‐up was 22 months (range 5‐29 months), and the follow‐up rate was 100%. The 1‐year and 2‐year OS was 95% and 95%, and the 1‐year and 2‐year DFS was 85% and 82%, respectively. Thirty‐eight (97.3%) successfully underwent R0 resection. Of the 38 evaluable patients, 9 (23.6%) were pCR, and 15 (39.5%) were MPR. The most common ATP‐related AEs were nausea (76.9%), leucopenia (53.8%), neutropenia (51.2%) and vomit (51.2%), anemia (41.0%), and hypertension (25.6%). The most frequent grade 3‐4 events included leucopenia (15.3%), neutropenia (15.3%), nausea (12.8%), vomit (12.8%), and hypertension (10.2%). No treatment‐related death occurred. Neoadjuvant apatinib combined with taxol and cisplatin for locally advanced ESCC showed favorable activity and manageable safety.
Variation Feature, Pollution Risk Assessment, and Source Analysis of Heavy Metals in Lanzhou City, Northwestern China
Authors: Zeng Yongyao , Zhou Bo
Published: July 2022

Lanzhou is located in the northwest of China and is famous for its petrochemical and heavy industries of China. The city has suffered long-term pollution of heavy metals in recent years. Significant efforts, such as tax subsidies for new energy vehicles and treating solid waste, have been launched by the Lanzhou municipal government to address the pollution of heavy metals since 2010. What is the current status of heavy metal pollution in Lanzhou? In this study, the concentrations of 12 heavy metals (V, Cr, Mn, Co, Ni, Cu, Zn, As, Mo, Cd, Sb, and Pb) were tested from 20 sediment samples. Mn, Zn, V, and Cr are the predominant heavy metals, with mean concentrations of 534.65, 65.85, 56.29, and 36.05 mg/kg; Ni, Cu, Pb, Co, and As are in moderate amounts, with mean concentrations of 25.2, 21.5, 16.7, 9.87, and 4.86 mg/kg; Mo and Cd have the lowest mean concentrations of 0.54 and 0.15 mg/kg. A low ecological risk is confirmed by two indices, the Hakanson potential ecological risk index (

R
I

) and the geoaccumulation index (

I

geo

). The

R
I

index has lower

E

i

r

values (<40) and

R
I

values (<150), which range from 18.11 to 37.95, with an average value of 25.61. Co, V, Cd, Cu, Zn, As, Cr, Ni, Pb, and Mn metals are classified as an uncontaminated environment (level 0) and a moderately to heavily contaminated environment (level 2-level 3) by

I

geo

values. Seven heavy metals (Pb, Cd, Cr, As, Cu, Zn, and Ni) in Lanzhou are the relatively lowest amount in the 5 cities in China. The changing trends of heavy metal concentrations firstly increase and then decrease gradually from 2005 to 2022. The time turning point of concentration shrinking occurred in approximately 2014, which is in response to the increased efforts of addressing the pollution launched by the Lanzhou municipal government since 2010. Source analysis by Pearson’s correlation and principal component analysis revealed that the accumulation of Mo metal was caused by the enrichment of MnO2 in the oxidic condition; the accumulations of Cu, Co, Ni, Mn, Cr, Zn, Cd, and Pb metals are influenced by natural sources and human activities (vehicle exhaust and industrial pollution), respectively.
Construction of Holographic Immersion Chamber Based on Multisource Information Fusion and Interactive Virtual Reality Technology
Authors: Wang Chunying , Liu Yin
Published: July 2022

Nowadays, many visual artists actively respond to the drastic changes taking place in today’s society, build a communication bridge between real places and virtual places, and use holographic image technology to organically integrate them with each other. We are increasingly shuttling through the network of unbounded space. These spaces have no fixed geographical location. With the help of modern science and technology, they often fall into the field of vision of the viewer. With the development of the times, virtual reality technology is a computer simulation system that can create and experience the virtual world. It mainly uses computers to generate a simulated environment. It is a multisource information fusion interactive virtual reality technology to help users immerse themselves in the virtual environment. This paper studies the holographic immersion chamber based on multisource information fusion interactive virtual reality technology. The approximation index of the transformation matrix calculated by the registration algorithm based on SIFT+MSA is 1.7073, which is less than 4.0017 obtained by SIFT matching algorithm. It can be seen that the error of CCD image registration parameters calculated by this algorithm is smaller. In the process of the development of multisource information fusion interactive virtual reality technology, the technical feature of virtual reality is gradually integrated into the user and application object, becoming more closely connected and finally causing the user of the technology the feeling of “immersion” in the use experience.
Risk Analysis and Countermeasures of Social Medical Insurance Based on Random Matrix Theory and Data Mining
Authors: Chen Cuixia
Published: July 2022

Accelerating the reform of social medical insurance risk analysis is an urgent need to establish a complete social medical insurance system. Based on random matrix theory and data mining technology, this study constructs a social medical insurance risk analysis model. After determining the subject of the data warehouse and the relevant information of each subject, it starts to build a random matrix data warehouse, and solves the social medical insurance risk through the data fact table and dimension quantitative indicators. In the simulation process, the model uses the Oracle Warehouse Builder (OWB) software to create the data warehouse, and systematically analyzes and studies the construction process of each table; when creating the server through data mining, we run the repository as an administrator program to create data mining workspace, including creating OWB username and password. The experimental results show that after analyzing related technologies such as data warehouse, OLAP, and data mining, the accuracy rate of abnormality is 79.0%, and the recall rate is 85.8%. After using random matrix sampling technology to balance the dataset, the algorithm effect accuracy rate reaches 89.3%, which can effectively provide professional help for the social security fund supervision department and the medical insurance business management department.
Study on Failure Mechanism and Control Technology of Roadway Surrounding Rock under Complex Occurrence Coal Seam
Authors: Wu Hai , Chen Jiaren , Gao Xu , Ling Tao , Zhang Xuan , Jia Qian
Published: July 2022

Aiming at the characteristics of large deformation and long deformation time under the mining influence of the 2254 east floor roadway surrounding rock, which under the condition of complex coal occurrence in Jiahe Mine. Through the actual measurement, it is found that the mineral composition of the roadway surrounding rock is mainly siderite, and it also contains 9.52% of kaolinite minerals, and the surrounding rock is relatively weak. Through drilling and peeping, it is found that the roadway surrounding rock is mainly thin-layered, and a large number of fissures are developed in the surrounding rock near the surface of the roadway. Through the in situ stress test, it is concluded that the in situ stress field of Jiahe Mine is dominated by horizontal stress, the minimum principal stress is vertical principal stress, and the lateral pressure coefficient exceeds 2, causing serious damage to the two sides of the roadway. Using the gas drainage drilling data of the 2254 east floor roadway and using SketchUp and Rhino software, the complex geological occurrence model of the coal seam above the roadway was constructed, and on this basis, the FLAC3D numerical calculation model was constructed. The analysis results show that the plastic zone of the roadway surrounding rock is large, the bolt anchoring section is within the plastic zone, and the control effect on the deformation of the roadway surrounding rock is poor. Therefore, a comprehensive support method of “reserved deformation, anchor rod, metal mesh, shotcrete, grouting anchor cable, and full-section grouting” is proposed. The monitoring results of the surrounding rock deformation of the roadway 12 months after construction show that the support scheme can effectively control the deformation of the roadway surrounding rock. The research results provide a reference for the stability control of similar roadways.
Fractional Versions of Hermite-Hadamard, Fejér, and Schur Type Inequalities for Strongly Nonconvex Functions
Authors: Xu Wenbo , Imran Muhammad , Yasin Faisal , Jahangir Nazia , Xia Qunli
Published: July 2022

In modern world, most of the optimization problems are nonconvex which are neither convex nor concave. The objective of this research is to study a class of nonconvex functions, namely, strongly nonconvex functions. We establish inequalities of Hermite-Hadamard and Fejér type for strongly nonconvex functions in generalized sense. Moreover, we establish some fractional integral inequalities for strongly nonconvex functions in generalized sense in the setting of Riemann-Liouville integral operators.
The Effect of GPX2 on the Prognosis of Lung Adenocarcinoma Diagnosis and Proliferation, Migration, and Epithelial Mesenchymal Transition
Authors: Li Yu-peng , Lin Rui , Chang Ming-zhu , Ai Yi-jiu , Ye Si-ping , Han Hui-ming , Zhang Yao-yue , Mou Han , Mu Run-hong , Guo Xiao
Published: July 2022

Objective. To investigate the expression of glutathione peroxidase 2 (GPX2) in human lung adenocarcinoma tissues and its effect on the biological function of lung adenocarcinoma A549 cells. Methods. The expression of GPX2 in lung adenocarcinoma and its effect on survival were analyzed by the TCGA database and the GEPIA 2 database. A total of 45 cases of primary lung adenocarcinoma tissue specimens and 45 cases of their paracancerous tissue specimens were collected, and the expression of GPX2 in the two types of tissues was detected by immunohistochemistry. Lung adenocarcinoma A549 cells were divided into the GPX2 overexpression group (GPX2), the GPX2 knockdown group (si-GPX2), the empty vector group (Vector), the siRNA negative control group (si-NC), and the WT group; the mRNA level and protein expression of GPX2 in each group of A549 cells were detected by real-time fluorescence quantitative PCR and Western blotting; the proliferation activity of each group of cells was detected by the CCK-8 assay; the effect of GPX2 on cell migration and invasion ability was detected by the scratch assay and the Transwell invasion assay; the apoptosis of each group of cells was detected by flow cytometry; Western blotting was performed to detect the expression levels of Bax, Bcl-2, E-cadherin, vimentin, and MMP2 and MMP9 proteins in each group of cells. Results. Bioinformatics analysis showed that the expression of GPX2 was strongly correlated with the prognosis of lung adenocarcinoma patients (

P
<
0.01

). The positive expression rates of GPX2 in lung adenocarcinoma and its paracancerous tissues were 66.0% and 15.7%, respectively (

P
<
0.05

). The results of RT-qPCR and Western blotting showed that the expression level of GPX2 mRNA and protein in A549 cells in the GPX2 group increased, which was significantly higher than that in the WT group (

P
<
0.05

); the expression levels of GPX2 mRNA and protein in A549 cells in the si-GPX2 group were the same, that is, significantly lower than the WT group (

P
<
0.05

). GPX2 overexpression promoted the proliferation, migration, and invasion of A549 cells and inhibited their apoptosis; the results in the si-GPX2 group were opposite to those in the GPX2 group. Compared with the WT group, the expression of Bcl-2, vimentin, and MMP2 and MMP9 protein in the GPX2 group increased (

P
<
0.05

), while the expression of Bax and E-cadherin protein decreased in the GPX2 group (

P
<
0.05

); the results in the si-GPX2 group were opposite to those in the GPX2 group. Conclusion. The expression of GPX2 in lung adenocarcinoma is related to the prognosis of patients. It is proved that GPX2 can promote the migration and invasion of lung adenocarcinoma cells and is related to the EMT/β-catenin pathway. Thus, GPX2 is expected to be an important target for the diagnosis and treatment of lung adenocarcinoma.
The Texture and Color Matching of Oil Painting Materials Based on Multimedia Visual Communication
Authors: Wang Feng , Sun Haozhang
Published: July 2022

The obvious tendency of modern artists to change the concept of painting is to pay more and more attention to personal feelings and spiritual expression. In modern oil paintings, there are more and more oil paintings that convey emotions and the emotional expression methods of the colors of the works are becoming more and more abundant. This article aims to study the application of multimedia visual communication in the texture and color matching of oil painting creation materials and to put forward the viewpoint of applying more multimedia visual communication to oil painting creation. This article first gives a detailed introduction to oil painting creation materials and their texture, oil painting color matching, and so on. In addition, experiments were conducted on the application of multimedia visual communication in the texture and color matching of oil painting creation materials. The experimental results show that the texture and color matching of oil painting creation materials based on multimedia visual communication are more popular with the public, and oil painters are also satisfied with this method. And, the expressiveness of oil painting texture has been improved by 10%. This shows that the texture and color matching scheme of the oil painting material in this study is effective.
SWOT Approach for Audience Online Conversion Rate: An Applied Research on Scenic Spot Projects
Authors: Ding Jiaran
Published: July 2022

With the rapid development of social economy and people’s increasing requirements for spiritual life, tourism projects are booming. At the same time, in order to improve their competitiveness, tourism regions also pay great attention to the attraction of performing arts projects to the audience, especially the online conversion rate. The original online conversion rate survey method cannot effectively judge the online conversion, and the comprehensive judgment ability is weak. At present, there is a lack of necessary analysis methods in the research of audience online conversion rate, so the research results cannot meet the actual requirements. Moreover, there are some deficiencies in the research depth of conversion rate at home and abroad. In order to shorten the abovementioned gap, comprehensive analysis methods should be applied to focus on online transformation. Based on the abovementioned reasons, this paper proposes a method based on SWOT to build a prediction model of audience online conversion rate. First, SWOT is used to cluster the data of strengths, weaknesses, potential dangers, and competitors and sort the data to judge the importance of different data, so as to improve the accuracy of the online conversion rate judgment results of viewers. Then, SWOT classifies the data to form analysis particles in different aspects and analyzes the co‐evolution and optimal results of analysis particles in different aspects. After a simulation test, the SWOT model constructed in this paper is superior to the online conversion rate survey method in terms of calculation accuracy and calculation time and the overall effect is higher. At the same time, the integration of threshold, weight, and other adjustment functions further enhances the analysis effect of SWOT model. Therefore, a SWOT model can accurately and quickly predict the online conversion rate of audience.
Evaluation of Application Effect of Self-Made Compression Cold Therapy in Postoperative Rehabilitation of Patients with Orthopedic Dyskinesia
Authors: Wan Xiaojuan , Ji Liping , Zhao Min , Zhu Shixiang , Tang Meixiu
Published: July 2022

With the accelerated aging of the population, orthopedic injuries have become more collective. Among them, the incidence of ankle fractures remains high. Surgery is an effective way to treat ankle fractures by utilizing special surgical site, complex anatomical structure, and specific surgical methods. With surgical approach, it is easy for basis postoperative blood loss, pain, swelling, and other problems. After surgery, most patients suffer from symptoms of fear, increased pain sensitivity, and excessive irrational concerns about physical movement or activity. Compression cold therapy combines cold therapy with air pressure therapy to ease local exudation, constrict blood vessels, improve circulation, relieve pain, and control inflammation through the effects of low temperature and pressure. Application during the rehabilitation period can prevent joint swelling, reduce muscle soreness, and promote the functional recovery of limbs, which provides an effective guarantee for postoperative rehabilitation of patients with orthopedic dyskinesia. Based on this, it is very important to evaluate the application and effect of self-made compression cold therapy in postoperative rehabilitation of patients with orthopedic dyskinesia. This work proposes a one-dimensional deep convolutional neural network-based method; DenseNet for analyzing the rehabilitation effect of patients with orthopedic dyskinesia after ankle fracture surgery. The approach is to evaluate the rehabilitation effect of self-made compression cold therapy from the perspectives of feature reuse, attention mechanism, and feature decoupling. Experiments on the dataset show that the proposed neural network has better efficacy evaluation performance. The proposed systematic assessment based on the emerging deep learning network has great significance in healthcare domain, particularly in assessing applicability, side effects, and noninvasiveness of treatment methods.
Xeroderma Pigmentosum: A Genetic Condition Skin Cancer Correlated—A Systematic Review
Authors: Brambullo Tito , Colonna Michele Rosario , Vindigni Vincenzo , Piaserico Stefano , Masciopinto Giuseppe , Galeano Mariarosaria , Costa Alfio Luca , Bassetto Franco
Published: July 2022

Background. Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder of UV radiation‐induced damage repair that is characterized by photosensitivity and a propensity for developing, among many others, skin cancers at an early age. This systematic review focused on the correlation between the clinical, pathological, and genetic aspects of XP and skin cancer. Methods. A systematic review was conducted through a literature search of online databases PubMed, Cochrane Library, SciELO, and Google Scholar. Search terms were “Xeroderma pigmentosum”, “XP”, “XPC”, “Nucleotide excision repair”, “NER”, “POLH”, “Dry pigmented skin”, and “UV sensitive syndrome” meshed with the terms “Skin cancer”, “Melanoma”, and “NMSC”. Results. After 504 abstracts screening, 13 full‐text articles were assessed for eligibility, and 3 of them were excluded. Ten articles were selected for qualitative assessment. Conclusions. Patients with XP usually suffer shorter lives due to skin cancer and neurodegenerative disease. Deletion/alteration of a distinct gene allele can produce different types of cancer. The XPC and XP‐E variants are more likely to have skin cancer than patients in other complement groups, and the most common cause of death for these patients is skin cancer (metastatic melanoma or invasive SCC). Still, aggressive preventative measures to minimize UV radiation exposure can retard the course of the disease and improve the quality of life.
Design of In-Depth Multi-intelligence Teaching System under the Mixed English Teaching Mode
Authors: Kuai Bin , Li Peihao
Published: July 2022

After the implementation of the hybrid network-based English teaching system, a wide-ranging trial was carried out in schools. Although the trial time was not very long, according to the feedback given by the students, it is not difficult for us to find that the practicability of the English network teaching system is very strong, which is very suitable for current college students. The main goals of this research are the application development of the open source Moodle course management system and the practical design and realization of the English network teaching system based on in-depth research on the Moodle system and the secondary development technology. In view of the development of the existing English online teaching system in China and the current situation of domestic audio-visual information construction, it is planned that Moodle, an open source and free software system that fully complies with the CPL and GPL protocols, is used to teach the English language through in-depth research on the software support system. The software bottom layer supports the network teaching system and then uses PHP and web technology to expand and integrate system functions according to different needs and finally realize an English network teaching system suitable for college students at this stage.
Effect on Compression Molding Parameters in Mechanical Properties of MWCNT/Glass Fiber/Epoxy Composites
Authors: Venugopal Jayaprakash , Dhanasakkaravarthi B. , Surakasi Raviteja , Rinawa Moti Lal , Manjunatha L. H. , Alshgari Razan A. , Wabaidur Saikh Mohammad , Islam Md Ataul , Jenish I.
Published: July 2022

Reinforcing fibers, nanofillers, matrix materials, and manufacturing techniques all have a role in the mechanical characteristics of hybrid composites. MWCNTs-reinforced E-glass/Kevlar/epoxy composites are appropriate fillers for structural applications. The impact of different concentrations of MWCNT fillers (0.4%, 0.8%, and 1.2% wt) on the mechanical characteristics of hybrid composites has been studied. Tensile and bending strength, as well as hardness, were measured in compression-molded composites. The effects of compression pressure, mold temperature, and applied pressure on hybrid (0.8% MWCNT) were investigated. When it came to composite tensile and bending strength, compression pressure was the most important factor, closely succeeded by mold temperature and pressure period. Compression molding were optimized, resulting in a tensile strength of 183 MPa, a bending strength of 158.3 MPa, and a hardness value of 23.8 HV.
Comparison and Clinical Value of Ciprofol and Propofol in Intraoperative Adverse Reactions, Operation, Resuscitation, and Satisfaction of Patients under Painless Gastroenteroscopy Anesthesia
Authors: Chen Xingqu , Guo Ping , Yang Li , Liu Zhuoling , Yu Deshui
Published: July 2022

Objective. To investigate the comparison and clinical value of ciprofol and propofol for painless gastroenteroscopy anesthesia in terms of intraoperative adverse reactions, operation, resuscitation, and satisfaction of patients. Methods. A total of 96 patients who underwent painless gastroenteroscopy anesthesia in our hospital from June 2021 to January 2022 were enrolled. The cases were randomly assigned into research group and control group. The control group received propofol anesthesia (n = 49), and the research group received ciprofol anesthesia (n = 47). The patients, physician satisfaction, vital signs, incidence of adverse reactions, anesthetic first dose, additional time, additional dose, total dose, induction time, insertion time, operation time, awake time, orientation recovery time, leaving room time, and injection pain score were compared. Results. The overall satisfaction of the study group was higher than that of the control group (p < 0.05). After taking medicine, the score of 1 min and MAP in the study group were higher than those in the control group. The incidence of adverse reactions in the study group was lower than that in the control group (p < 0.05). The satisfaction of doctors in the study group was higher than that in the control group (p < 0.05). The anesthesia induction time, intubation time, operation time, awake time, orientation recovery time, and leaving room time in the study group were significantly longer than those in the control group (p < 0.05). The incidence and degree of injection pain in the propofol group were significantly lower than those in the propofol group (p < 0.05). Conclusion. In painless gastroenteroscopy, compared with propofol, ciprofol is equally safe and effective for patients and will not cause early cognitive dysfunction after operation, which is a good choice in painless gastroenteroscopy anesthesia. In addition, ciprofol has significant advantages in patient and physician satisfaction, especially in injection pain. This trial is registered with ChiCTR2100045400.
Network Security Problems and Countermeasures of Hospital Information System after Going to the Cloud
Authors: Gao Shuming
Published: July 2022

In the current social context, information technology, network technology, and cloud computing have been widely used in all walks of life. The analysis of the specific application results of progressive technology shows that the use of technology has changed the working state of various industries and improved the work efficiency and quality of the industry. It should be noted that although the application of some technologies will bring many positive belongings, the potential risks brought by them cannot be ignored. As far as the hospital is concerned, the information system using cloud computing technology can make better use of the hospital’s information data, but after the information system is on the cloud, new problems will appear in network security, resulting in the leakage of hospital patient information or research information. Based on this, in practice, it is necessary to analyze the network security problems after the hospital information system goes to the cloud and build and implement the corresponding strategies. The author analyzes and discusses the corresponding contents through work practice and combined with previous articles, in order to provide guidance and help for peers.
Cyclocreatine Suppresses Creatine Metabolism and Impairs Prostate Cancer Progression
Authors: Patel Rachana , Ford Catriona A. , Rodgers Lisa , Rushworth Linda K. , Fleming Janis , Mui Ernest , Zhang Tong , Watson David , Lynch Victoria , Mackay Gillian , Sumpton David , Sansom Owen J. , Vande Voorde Johan , Leung Hing Y.
Published: July 2022

Prostate cancer is the second most common cause of cancer mortality in men worldwide. Applying a novel genetically engineered mouse model (GEMM) of aggressive prostate cancer driven by deficiency of the tumor suppressors PTEN and Sprouty2 (SPRY2), we identified enhanced creatine metabolism as a central component of progressive disease. Creatine treatment was associated with enhanced cellular basal respiration in vitro and increased tumor cell proliferation in vivo. Stable isotope tracing revealed that intracellular levels of creatine in prostate cancer cells are predominantly dictated by exogenous availability rather than by de novo synthesis from arginine. Genetic silencing of creatine transporter SLC6A8 depleted intracellular creatine levels and reduced the colony-forming capacity of human prostate cancer cells. Accordingly, in vitro treatment of prostate cancer cells with cyclocreatine, a creatine analog, dramatically reduced intracellular levels of creatine and its derivatives phosphocreatine and creatinine and suppressed proliferation. Supplementation with cyclocreatine impaired cancer progression in the PTEN- and SPRY2-deficient prostate cancer GEMMs and in a xenograft liver metastasis model. Collectively, these results identify a metabolic vulnerability in prostate cancer and demonstrate a rational therapeutic strategy to exploit this vulnerability to impede tumor progression.

Significance:

Enhanced creatine uptake drives prostate cancer progression and confers a metabolic vulnerability to treatment with the creatine analog cyclocreatine.
How Climate Change May Threaten Progress in Neonatal Health in the African Region
Authors: Nakstad Britt , Filippi Veronique , Lusambili Adelaide , Roos Nathalie , Scorgie Fiona , Chersich Matthew F. , Luchters Stanley , Kovats Sari
Published: July 2022

Climate change is likely to have wide-ranging impacts on maternal and neonatal health in Africa. Populations in low-resource settings already experience adverse impacts from weather extremes, a high burden of disease from environmental exposures, and limited access to high-quality clinical care. Climate change is already increasing local temperatures. Neonates are at high risk of heat stress and dehydration due to their unique metabolism, physiology, growth, and developmental characteristics. Infants in low-income settings may have little protection against extreme heat due to housing design and limited access to affordable space cooling. Climate change may increase risks to neonatal health from weather disasters, decreasing food security, and facilitating infectious disease transmission. Effective interventions to reduce risks from the heat include health education on heat risks for mothers, caregivers, and clinicians; nature-based solutions to reduce urban heat islands; space cooling in health facilities; and equitable improvements in housing quality and food systems. Reductions in greenhouse gas emissions are essential to reduce the long-term impacts of climate change that will further undermine global health strategies to reduce neonatal mortality.
Evaluation of the Dementia Apraxia Test in Parkinson’s Disease Patients
Authors: Renftle Daniela , Becker Sara , Brockmann Kathrin , Gasser Thomas , Michaelis Katja , Solbrig Susanne , Sulzer Patricia , Johnen Andreas , Liepelt-Scarfone Inga
Published: July 2022

Introduction: Ideomotor apraxia, a disorder of skilled movements affecting limbs and/or face, can be seen in patients with Parkinson’s disease (PD), yet tests of apraxia in PD are rare. The aim of this project was to evaluate the psychometric properties and validity of the Dementia Apraxia Test (DATE) in a PD sample. Methods: 118 PD patients were included. Besides DATE performance, motor and non-motor burden, cognition, and activity of daily living (ADL) function were assessed. Patients were classified as cognitively impaired (n = 41) or non-cognitively impaired (n = 77). Results: Interrater reliability of the DATE (sub-)scores between video ratings and on-site ratings by the investigator was good (0.81 ≤ rk ≤ 0.87). Items were mostly easy to perform, especially the buccofacial apraxia items, which had also low discriminatory power. DATE scores were associated with cognition and ADL function. DATE performance was confounded by motor impairment and patients’ age; however, when analysed for both cognitive groups separately, the correlation between DATE and motor performance was not significant. Discussion/Conclusion: The DATE seems to be an objective and predominantly valid apraxia screening tool for PD patients, with a few items needing revision. Due to the potential effect of motor impairment and age, standardized scores adjusting for these confounders are needed.
As perífrases com o verbo dever na tradução portuguesa da Vita Christi de Ludolfo de Saxónia
Authors: Machado José Barbosa
Published: July 2022

Pretendemos com este estudo identificar as ocorrências das perífrases formadas pelo verbo dever na edição portuguesa impressa da Vita Christi, qual o seu valor semântico, quais os tempos mais usuais do verbo semiauxiliar, que pronomes dependem do verbo semiauxiliar e quais os verbos principais no infinitivo. Pretendemos ainda fazer referência a alguns casos particulares, como o reforço do verbo semiauxiliar com outro verbo ou expressão verbal e a formação de perífrases complexas. As perífrases em análise têm as seguintes configurações: dever + infinitivo, dever + de + infinitivo e dever + a + infinitivo. As duas últimas deixaram de pertencer ao português padrão, sendo frequentes em textos do século XV. A perífrase dever + infinitivo ainda hoje é amplamente utilizada na língua portuguesa. A Vita Christi, que serve de corpus a este estudo, é uma obra religiosa composta em latim que narra a vida evangélica de Cristo, da autoria de Ludolfo de Saxónia (c. 1295-1377). Traduzida para português na época do rei D. Duarte (1391-1438), foi impressa em Lisboa em 1495 pelos impressores alemães Valentino de Morávia e Nicolau da Saxónia. Pela sua extensão (1173 páginas em quatro partes), é uma ótima base para estudos acerca das características do português no século XV.
SÖZLEŞMELİ ÜRETİCİ DÜNYA MARKASI OLABİLİR Mİ? YAŞANAN PROBLEMLER VE ÇÖZÜM ÖNERİLERİ
Authors: KARA Elif , ULAŞ Dilber
Published: July 2022

Sözleşmeli üretim, bir firmanın üretim süreçlerinin bir kısmını sözleşmeye dayalı olarak yaptırdığı bir tedarik zinciri düzenlemesidir. Bu çalışmada sözleşmeli üretimin nedenleri, sözleşmeli üreticilerin marka oluşturmada yaşadıkları sorunlar ve sözleşmeli üreticilerin görüşleri incelenmiştir. Literatür taraması yapılarak, araştırmanın metodolojisi tartışılmıştır. Veriler, yedi sözleşmeli üretici ile yüz yüze yarı yapılandırılmış görüşmeler yoluyla toplanmıştır. Çalışma sonucunda, sözleşmeli üreticilerin pazarlama ve markalaşmayı ayrı bir uzmanlık alanı olarak gördükleri, pazarlama ve markalaşmaya yeterli yatırım yapamadıkları tespit edilmiştir. Sözleşmeli üreticilerin marka geliştirmeleri için teşviklerin daha erişilebilir hale getirilmesi, tasarımın önemi, üretim standartları, uluslararası fuar ve sergiler, pazarlama eğitimleri konusunda farkındalık yaratılması önerilmektedir.
MUHASEBE EĞİTİMİNDE E-MUHASEBE VE ENDÜSTRİ 4.0 TEKNOLOJİSİ DERSLERİ ÜZERİNE MÜFREDAT ÖNERİSİ
Authors: BAĞDAT Aydın
Published: July 2022

Çalışmanın amacı, içinde olduğumuz e-dönüşüm sürecinde yükseköğretim düzeyinde muhasebe eğitimi verilen bölümlerde e-muhasebe ve endüstri 4.0 teknolojilerini kapsayan derslerin yeterliliğini ortaya koymaktır. Bu kapsamda Türkiye’de müfredatında muhasebe dersleri yer alan bölümlerin ders planları doküman analizi yöntemiyle incelenmiş ve e-muhasebe ile endüstri 4.0 teknolojilerini içeren dersler taranmıştır.

Çalışmada 13 üniversitede muhasebe ile ilişkili bölümlerin ders planlarında e-muhasebe, e-muhasebe uygulamaları, muhasebe yazılımları ve e-muhasebe, sanayi 4.0, yapay zeka, dijital dönüşüm ve yapay zeka adlı derslere seçmeli ve zorunlu olarak yer verildiği tespit edilmiştir. Ayrıca 1 üniversitede tüm ön lisans programlarında, doğrudan endüstri 4.0 teknolojisi derslerini içeren seçmeli ders havuzunun oluşturulduğu görülmüştür. Çalışma ile yükseköğretimde muhasebe alanında eğitim veren bölümlerde endüstri 4.0 teknolojisi ve e-muhasebe derslerine daha fazla önem verilmesi gerektiği sonucuna ulaşılmıştır.
Effective Approaches to Neural Query Language Identification
Authors: Ren Xingzhang , Yang Baosong , Liu Dayiheng , Zhang Haibo , Lv Xiaoyu , Yao Liang , Xie Jun
Published: July 2022

Query language identification (Q-LID) plays a crucial role in a cross-lingual search engine. There exist two main challenges in Q-LID: (1) insufficient contextual information in queries for disambiguation; and (2) the lack of query-style training examples for low-resource languages. In this article, we propose a neural Q-LID model by alleviating the above problems from both model architecture and data augmentation perspectives. Concretely, we build our model upon the advanced Transformer model. In order to enhance the discrimination of queries, a variety of external features (e.g., character, word, as well as script) are fed into the model and fused by a multi-scale attention mechanism. Moreover, to remedy the low resource challenge in this task, a novel machine translation–based strategy is proposed to automatically generate synthetic query-style data for low-resource languages. We contribute the first Q-LID test set called QID-21, which consists of search queries in 21 languages. Experimental results reveal that our model yields better classification accuracy than strong baselines and existing LID systems on both query and traditional LID tasks.1
More microinvasive foci in larger tumours of breast ductal carcinoma in situ
Authors: Chen Xiao-Yang , Thike Aye Aye , Lim Johnathan Xiande , Bay Boon Huat , Tan Puay Hoon
Published: July 2022

Introduction:

Microinvasion (Mi) is often thought to be an interim stage between ductal carcinoma in situ (DCIS) and invasive ductal carcinoma. This study aimed to investigate the potential influence of Mi on survival and assess its correlations with clinicopathological parameters, prognosis and molecular markers.

Methods:

The number of Mi foci in a cohort of 66 DCIS-Mi cases was assessed from haematoxylin and eosin–stained sections. Disease-free survival, clinicopathological parameters and biomarker expression were correlated with the number of Mi foci.

Results:

Higher numbers of Mi foci were found in larger tumours (P = 0.031).

Conclusion:

Greater extent of DCIS is associated with multifocal Mi.
10. Maggot-assisted Wound Healing
Authors: Nigam Yamni , Wilson Michael R.
Published: July 2022

Unlike any other wound care device or pharmaceutical, medicinal maggots convey multiple therapeutic benefits at the same time when applied to chronic and/or infected wounds. In addition to providing an ideal healing environment through debridement and infection control, maggot excretions and secretions actively promote wound healing through a wide range of specific physiological mechanisms and pathways. After a brief review of early studies into the healing properties of medicinal maggots, and what is known from randomised clinical trials, the chapter explains in detail the biochemical and physiological principles of maggot-mediated wound healing.
15. Establishment of a Medical Maggot Rearing Facility and Maggot Therapy Programme for Human and Veterinary Medicine in Kenya
Authors: Takáč Peter , Kozánek Milan , Murilla Grace A. , Mukiria Phoebe , Kinyosi Bernard Wanyonyi , Chemuliti Judith K. , Wanjerie J. Kimani , Kibiwott Christopher K. , Stadler Frank
Published: July 2022

This case study describes the process and experience of establishing a maggot therapy programme in Kenya. Initially, the programme included a technology- and knowledge-transfer initiative which successfully developed production capacity and clinical skills among the surgical and nursing workforce at Kenyatta National Hospital. This work was followed by a pilot study that demonstrated the positive impact mainstreaming of maggot therapy can have on the treatment of patients with chronic and infected wounds. The project highlights the importance of regulatory and supply-chain barriers that need to be addressed from the outset when introducing maggot therapy to new markets.
Exploring the Role of Deep Moist Convection in the Wavenumber Spectra of Atmospheric Kinetic Energy and Brightness Temperature
Authors: Fan Da , Greybush Steven J. , Chen Xingchao , Lu Yinghui , Zhang Fuqing , Young George S.
Published: July 2022

Through a series of global convection-permitting simulations and geostationary satellite observations, this study investigates the role of deep moist convection in atmospheric kinetic energy (KE) and brightness temperature (BT) spectra in a realistic framework. The control simulation was produced on a quasi-uniform 3-km global mesh, which allowed the explicit representation of deep convection. To assess the impact of deep moist convection, a fake-dry simulation was performed with latent heating–cooling feedback in the microphysics removed for comparison. The impacts of deep moist convection on mesoscale KE spectrum are concentrated on energizing the mesoscale at the upper troposphere and the lower stratosphere through buoyancy production. BT spectra for the control simulation have a similar shallow slope in the mesoscale as that for the observations. The greater spectral power of BT for the control simulation compared to the observed is attributed to the dislocation and higher intensity of simulated convection. The observed BT spectra exhibit a large diurnal variability due to the diurnal variation of the intensity of convection. The simulated BT spectrum is dependent on convective systems at different scales. Deep convection in the intertropical convergence zone (ITCZ) and shallow convection in the North Pacific storm-track region play an important role in energizing the convective scale of the BT spectrum. In the mesoscale, the BT spectrum is mainly energized by mesoscale convective systems (MCSs) in the ITCZ. Tropical equatorial waves and baroclinic waves in the southern midlatitudes are critical in producing the shallow slope near −5/3 and providing energy in the BT spectrum at the synoptic scale.

Significance Statement

We further explore the role of deep moist convection in kinetic energy and brightness temperature spectra through high-resolution radiance observations and convection-permitting simulations. Moist processes can energize the mesoscale of kinetic energy. Brightness temperature spectra show dependence on convective systems at different scales. These results point the way toward a new approach to evaluate the predictability of convective systems, and future development of model dynamics and parameterization.