bluuebunny/crossref_metadata_2025 huggingface dataset:
“Diariush”, or “Day Notes” of Saint Dimitry of Rostov as an Early Attempt of Diary Literature in Russia
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Krasheninnikova Olga A.
Published: August 2022

“Diariush”, or “Daily Notes” of St. Dimitry of Rostov is a small but very important work of the saint, his diary, in which he recorded the main stages of his biography, the days of memory of his relatives and friends, his prophetic dreams and visions. The testimonies of “Diariush” were later used as the basis for the Synodal edition of the Life of St. Dimitry. The article deals with the main documentary and artistic sources of the diary — the martyrology (memorial) of St. Dimitry, his travel diary, autobiographical story, epistolary, etc. The author of the article makes a conclusion, that “Diariush” is the literary monument, which contains two temporary layers: a real, historical time and the circle of the annual Church memories of Minei-Chetii, i. e. time earthly and eternal. The sanctity of the author of the diary was expressed by his sense of belonging not only to the earthly, but also to the heavenly reality.
Poetics of Medieval Vita in Biographical Prose of the First Half of the 18th Century
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Krasheninnikova Olga A.
Published: August 2022

The article is devoted to the relationship between the genres of vita and autobiography in the 17th–18th centuries, when the genre of traditional vita increasingly faded into the past, giving way to literary biography. Despite this, the poetics of vita still had a serious influence on the structure of the new, secular literature, the “literature of fact”. The article analyzes the literary autobiography of M.P. Avramov, which was included in his “Petition” (1749), addressed to the Empress Elizabeth, in which the medieval poetics of the miraculous still occupied an important place in the spiritual biography of the hero. The numerous miracles described by Avramov in his “Confessions” give grounds to assert that this prominent figure of the Russian Enlightenment of Peter’s time combined the idea of devoted civil service to Peter I and the new Russian state with a commitment to traditional religious-conservative thinking, which was reflected in the genre and poetics of his autobiography.
ANALISIS NILAI TAMBAH PENGELOLAAN PISANG RAJA MENJADI KERIPIK PISANG DI IKM SAHRUL DESA RAMPADENDE KECAMATAN DOLO BARAT KABUPATEN SIGI
Authors: Ferdiansyah Koko , Howara Dafina , Alaihi Moh Alfit
Published: August 2022

Sahrul SMEs is an example of a real contribution to the industrial-based agriculture sector by processing banana king into chips to provide more selling value. The availability of abundant Banana king commodities makes Sahrul SMEs utilize these commodities as raw materials in food-based industrial activities. However, the price of some supporting materials used in processing banana king into banana chips is still relatively high and some processes use large costs. Because of this, there needs to be an analysis of income and the amount of added value on banana chips till business can develop and continue. This study aims to determine how much one-time production income and to find out the value added of banana chip products at Sahrul SMEs. This research was carried out at Sahrul SMEs, Rampadende Village Dolo Barat District Sigi Regency, in September-November 2019. The results showed that the income earned by Sahrul SMEs in one month of production was Rp.2,096,458, - value added analysis of Rp. 141,000 with a ratio of 0.64% of the raw materials used with a profit of Rp. 120,167 or 0.85% of every one banana bunch used.
FAKTOR-FAKTOR YANG MEMENGARUHI PRODUKSI USAHATANI BAWANG MERAH LEMBAH PALU DI DESA LABUAN TOPOSO KECAMATAN LABUAN KABUPATEN DONGGALA
Authors: Maradhika Moh Sigit , Alam Max Nur , Effendy Effendy
Published: August 2022

The production of Palu valley shallots in Labuan Toposo Village is 302 tonnes with a harvest area of 76 ha, where Labuan Toposo Village is the village that has the highest production of Palu valley shallots (302 tonnes for 76 ha or 3.9 tonnes / ha). This research aims to determine the effect of production factors on land area, seeds, urea fertilizer, ZA fertilizer, Ponska fertilizer and labor on Palu valley shallot production in Labuan Toposo Village, Labuan District, Donggala Regency.The data analysis used is the Cobb-Douglas production analysis.Based on the results of the analysis and discussion of the data above, conclusions can be drawn by looking at the value of Fcount 30.976 ˃ F table 2.49 at α = 5%, which means that the null hypothesis (H0) is rejected, so the independent variables are land area, seeds, urea fertilizer, ZA fertilizer, Ponska fertilizer and labor (simultaneously) have a significant effect on Palu valley shallot production in Labuan Toposo Village. Whereas partially or respectively the influence of the Urea fertilizer, ZA fertilizer, Ponska fertilizer, and Labor variables had no significant effect on production, while the use of land area and seed variables had a significant effect on Palu valley shallot production in Labuan Toposo Village, Labuan District. Donggala Regency
ANALISIS PENDAPATAN USAHATANI PADI SAWAH SELAMA PANDEMI COVID-19 DI DESA WATUNONJU KECAMATAN SIGI BIROMARU KABUPATEN SIGI
Authors: Ananda Putri , Nurmedika Nurmedika
Published: August 2022

This study aims to determine the income of lowland rice farming during the Covid-19 pandemic in Watunonju Village. Determination of the location is done intentionally (purposive), the number of respondents as many as 35 people from the population of rice farmers as many as 160 people. Determination of respondents using the Slovin formula. Analysis of the data used is income analysis. The results of this study show that the average total farming costs incurred during the Covid-19 pandemic are Rp. 6,562,208.06/1.1Ha/MT or Rp. 5,900,463.69/1.1Ha/MT. The average income obtained by farmers is Rp.15,176,571.42/1.1Ha/MT or Rp. 13,796,883.12/1.1Ha/MT of the average production of 1,686.28/1.1Ha/MT multiplied by the average selling price of rice at the farmer level of Rp. 9,000/Kg so that the average income of paddy rice respondent farmers in Watunonju Village during the Covid-19 Pandemic in one planting season is Rp. 8,614,363.37/1.1Ha/MT or Rp. 7,831,239.43/1.0/Ha/MT.
MANAJEMEN PERSEDIAAN BAHAN BAKU BAWANG PUTIH GORENG PADA UKM SOFIE LOCALFOOD DI KOTA PALU
Authors: Stevani Susi Agus , Dance Dance , Khatima Husnul
Published: August 2022

Garlic Sofie Localfood is one of the businesses engaged in agro-industry that utilizes garlic as the main raw material. Sofie Localfood's fried garlic products still have difficulty in regulating the production process, due to delays in ordering raw materials, so SMEs buy raw materials elsewhere and require more costs and sometimes the raw materials are not as expected. Raw materials are one of the most important production factors because they support the smooth running of the production process. This study aims to find out how much economic raw material purchases (EOQ) for the supply of raw materials to SMEs Sofie Localfood, to find out how much safety stock (Safety Stock) to SMEs Sofie Localfood, to find out when is the right time for SMEs Sofie Localfood to do reordering (ROP) of raw material inventory, and to find out the total inventory cost (TIC) of raw materials at UKM Sofie Localfood, This research was conducted at UKM Sofie Localfood on Jalan Zebra IV, Lorong 1 No. 5 Palu City. The selection of this location was done purposively, with the consideration that Sofie Localfood is one of the businesses that produces garlic as the main raw material for making tempeh in Palu City. This research was conducted from April to June 2021. Respondents are owners and employees of UKM Sofie Localfood who were selected as sources of information in the study, the total number of respondents is 3 people. Based on data to be obtained from Sofie Localfood's business regarding raw material inventory management issues tempe, the data analysis used is Economic Order Quantity (EOQ), Safety Stock (Safety Stock), reorder (ROP) and total inventory cost (TIC). The results of this study indicate that the management of raw material inventory at SMEs Sofie localfood using the (Economic Order Quantity) method in JanuaryDecember 2020 an average of 31.17 kg/month. Safety stock (Safety Stock) of raw materials that is always available at UKM Sofie Localfood is 14.92 kg/month. The reorder point (reorder point) that SMEs Sofie Localfood must make in April-June 2021 is an average of 77.26 kg/month. The total cost of raw material inventory for garlic in the UKM Sofie Localfood is an average of Rp.58.157.86/month.
ANALISIS PEMASARAN KAKAO DI DESA OMU KECAMATAN GUMBASA KABUPATEN SIGI
Authors: Pratama Andrew Anugrah
Published: August 2022

Cacao (Theobroma cacao L) is a type of plantation that is often found in the Central Sulawesi Region. One area that can produce cocoa is Sigi Regency, there are 15 districts that can produce cocoa production in Sigi Regency. The purpose of this study was to determine the form of marketing channels, marketing margins, the share of prices received by farmers (producers) of cocoa and the efficiency of cocoa marketing in each channel in Omu Village, Gumbasa District, Sigi Regency. The results of the analysis show that there are two forms of marketing channels in Omu Village, Gumbasa Subdistrict, Sigi Regency, namely: Channel I) producers sell cocoa to collectors, then sell it to large traders and sell it again to end consumers (Brown House Industry). Channel II) Manufacturers sell cocoa to large traders, then wholesalers sell to end consumers. The total marketing margin of cocoa obtained in the first channel is Rp. 5,500, and the total margin obtained in the second channel is Rp.3,000. The share of prices received by producers in channel I was 82.53% while the share of prices received by producers in channel II was 90.47%. Marketing efficiency of channel I was 2.06%, and channel II was 1.82%, so channel II was more efficient than channel I.
ANALISIS PENDAPATAN USAHATANI KELAPA SAWIT POLA KEMITRAAN DENGAN PERUSAHAAN PT. LETAWA DI DESA MAKMUR JAYA KECAMATAN TIKKE RAYA KABUPATEN PASANGKAYU
Authors: Sutriadi Sutriadi , Hadayani Hadayani , Antara Made
Published: August 2022

The purpose of this study was to determine the partnership pattern and income of oil palm farmers in partnership with the company Astra Agro Lestai (PT. Letawa) in Tikke Village, Tikke Raya District, Pasangkayu Regency. The research was conducted in December 2019 - February 2020. The determination of respondents in this study was carried out. by means of the census method. Data collection in this study uses primary and secondary data. The data analysis tool used is descriptive analysis to describe the general conditions of the research area. The partnership pattern developed by farmers in Makmur Jaya Village with the company PT. Letawa on October 25, 2013 is a partnership scheme of PIR-BUN IGA, namely PT. Letawa. The results showed that the current price of fresh fruit bunches is Rp 1.175 / kg FFB (Fresh Fruit Bunches). Average income of oil palm farmers in Makmur Jaya Village, Tikke Raya Subdistrict, Pasangkayu Regency in partnership with the company Astra Agro Lestari (PT. Letawa) with an income of Rp 49,509,800 / 2.62ha or Rp 18,920,800 / ha minus the total cost amounting to Rp 18,765,397 / 2.62ha or Rp 7,171,489 / ha. So the income earned by oil palm farmers is Rp 30,744,403 / 2.62ha or Rp 11,749,453 / ha. The net income received by farmers after being cut by 30% from the company PT Letawa, the average income of oil palm farmers is Rp26,132. 743 / 2.62ha or Rp 9,987,035 / ha.
Determinants of capital structure of French SBF 120 listed companies: A comparison between trade-off theory and pecking order theory
Authors: Ben Said Houda
Published: August 2022

In this paper, we attempt to identify the firm-specific determinants of the capital structure of a sample of non-financial firms listed on the SBF 120 French index between 2009 and 2019 and to test whether the determinants offered by the two principal financial theories (e.g., trade-off theory and pecking order theory) are able to provide convincing explanations for their behavior in terms of financing decisions. Capital structure determinants discussed are size, profitability, asset tangibility, growth opportunities, liquidity, effective tax rate, and risk. The empirical analysis is carried out within a panel data estimation framework. Panel estimation techniques of fixed and random effects and ordinary least squares (OLS) estimation have been to test the hypothesized relationships. Empirical results showed that the majority of determinants had been significant. The size of the firm and its previous leverage have been found positively related to present leverage. The growth opportunities and the profitability have been found negatively related and the asset tangibility, the effective tax rate, and the firm risk were not significant. Then two variables follow the trade-off theory predictions, two variables follow those of the pecking order and three others do not follow anyone. No theory alone then can best explain the behavior of the French firms in terms of capital structure. But none of them can be rejected
High-Performance In0.53Ga0.47As/InAs/In0.53Ga0.47As Composite Channel Metamorphic HEMTs (MHEMTs) on GaAs Substrate
Authors: Shin Seung Heon , Shim Jae-Phil , Jang Hyunchul , Jang Jae-Hyung
Published: August 2022

In this work, we successfully demonstrated
In0.53Ga0.47As/InAs/In0.53Ga0.47As
composite channel metamorphic high electron mobility transistors
(MHEMTs) on GaAs substrate for the first time. The fabricated MHEMTs
with 100 nm gate length exhibited excellent DC and logic characteristics
such as VT = -0.13V, gm,max = 949 mS/mm,
subthreshold swing (SS) = 84 mV/dec, drain-induced barrier lowering
(DIBL) = 89mV/V, and Ion/Ioff ratio =
9.8 X 103 at VDS = 0.5 V. In addition,
the device exhibited excellent high frequency characteristics such as
fT/fmax = 261/304 GHz at
VDS = 0.5 V and these high frequency characteristics is
the well-balanced demonstration of fT and
fmax in the MHEMT structure on GaAs substrate.
Commentary: Small Patients with Big Wounds
Authors: Young Andrew , Norman Anthony , Kron Irving
Published: August 2022

Some would argue that kids aren’t just little adults, but what about
their sternums? We are reviewing a manuscript by Horriat, McCandless,
and colleagues in the Journal of Cardiac Surgery1 describing their
experience with managing sternal wound infections (SWI) after congenital
heart surgery. They report encouraging results in 14 patients who
required plastic surgery consultation to manage their sternal wounds.
The nature of congenital cardiac abnormalities and the necessary steps
to repair them leads to physiologic derangements predisposing patients
to SWI. Rates of SWI vary and have been reported at 1.53% in this
population. There is little guidance on how the management of the
congenital cardiac surgery patient should differ from the adult
patient.2
Function of Vitellogenin receptor gene in reproductive regulation of Zeugodacus cucurbitae (Coquillett) under the high-temperature background
Authors: Lian Yuyang , Peng sihua , Jia Jingjing , Li Jinlei , Wang Aqiang , Yang Shuyan , Zheng Rongjiao , Yang Xiaofeng , shi-hao zhou
Published: August 2022

Climate warming has increased the frequency of extreme heat events, and
Zeugodacus cucurbitae , as an important tropical pest,extreme heat tends
to change its reproductive strategies.To clarify the reproductive
strategies of Z. cucurbitae under the background of high temperature, Z.
cucurbitae were exposed to short-term high temperatures of
25°C,33°C,37°C,41°C,and 45°C for 1h in this paper, and effects of these
temperatures on the reproduction of Z. cucurbitae in three consecutive
generations (F1,F2,and F3 generations) were evaluated, followed by using
siRNA to interfere with the expression of Vitellogenin receptor(VgR)
gene and evaluated the silencing efficiency of RNAi.The results showed
that(1) short-time high temperature was generally detrimental to the
reproduction of Z. cucurbitae, but the F1 exposed at 45°C for 1h
stimulated its oviposition and when the offspring (F2andF3) were
continuously exposed to 45°C-1h short-term high temperature,F3 could not
survive.(2) After short-time high-temperature treatment, the injection
of siRNA resulted in significant inhibition of VgR gene expression at
24h and72h.The total oviposition quantity, oviposition days, and
hatchability of eggs after the interference were significantly lower
than the other groups, and the inhibition effect of total oviposition
quantity was the most obvious, decreasing by 88.4% and 95.2% at 25°C
and 45°C, respectively, compared with the control check (CK). The
ovarian development and ovarian diameter were also significantly lower
than the other groups. In conclusion, the VgR gene is essential for the
regulation of reproduction in Z. cucurbitae.This study can provide a
reference for the integrated control of Z. cucurbitae in the
high-temperature seas
Clinical Manifestations of EVALI in Adolescents Before and During the COVID-19 Pandemic
Authors: Abdallah Bayan , Lee Harin , Weerakoon Sitara M. , Messiah Sarah , Harrell Melissa , Rao Devika
Published: August 2022

Introduction: E-cigarette, or vaping, product use-associated lung injury
(EVALI) results from inhaling the aerosol of e-cigarettes and has
similar clinical features to coronavirus disease 2019 (COVID-19). EVALI
case counts since the declaration of the COVID-19 pandemic is unknown.
Methods: A retrospective electronic health record chart review of
adolescents hospitalized at one institution with EVALI was conducted.
Clinical characteristics and hospital course of patients hospitalized
during the pandemic were compared to those pre-pandemic. Results: The
clinical presentation of adolescents hospitalized prior-to (n=19) and
during the COVID-19 pandemic (n=22) were similar with respect to
constitutional, respiratory, and gastrointestinal symptoms. All patients
hospitalized during the pandemic were tested for COVID-19 at least once.
Only one patient had a positive SARS-CoV-2 RT-PCR test result. 31 out of
39 patients treated with corticosteroids had clinical improvement within
24 hours (79%). Patients hospitalized during the pandemic had a shorter
median length of stay (5 vs 7 days, p<0.01), and were less
often discharged with home oxygen (1 vs 6 patients, p=0.04). Pulmonary
function tests improved pre-to post-corticosteroid treatment and
post-corticosteroid to follow-up. Conclusions: Eliciting a history of
vaping in adolescents presenting with constitutional, respiratory, and
gastrointestinal symptoms is important to identify EVALI cases, which
have continued throughout the COVID-19 pandemic. A shorter length of
stay with less need for mechanical ventilation and home oxygen in
adolescents hospitalized during the pandemic may reflect increased
familiarity with EVALI characteristics. Corticosteroids led to clinical
and pulmonary function improvement.
Small Intestinal Metastasis From Lung Cancer: a rare case
Authors: Rejab Haitham , Fendri sami , Trigui Ayman , Abid Bassem , Mejdoub Youssef , ketata salma , Ameur Hazem Ben , Boujelbene Salah
Published: August 2022

we report the case of a 61-year-old male patient who was admitted with
abdominal pain, vomiting and constipation. he had a past medical history
of epidermoid lung cancer .computed tomography revealed distended
stomach with mural bowel thickening. it was peroperatively two
small-bowel metastasis from lung cancer that we resect.
QUARTO III. Response rate in cardiac resynchronization therapy patients implanted with a left ventricular quadripolar lead and the MultiPoint TM Pacing feature activated.
Authors: Osca Joaquín , Francisco-Pascual Jaume , Martínez-Basterra Javier , Martinez Juan Gabriel , Reis Hipólito , Oliveira Mario , Campos Bieito , Balaguer Javier , Sanz Jerónimo Rubio , Pavón-Jiménez Ricardo , Afonso Julio Hernández , Ormaetxe Jose Miguel , Zamorano Jose , Santamaría Pilar , Alzueta Javier
Published: August 2022

BACKGROUND: Although cardiac resynchronization therapy (CRT) is
beneficial in most heart failure patients, up to 40% do not respond to
CRT. It has been suggested that multipoint left ventricle pacing (MPP)
would increase the response rate. AIM: To assess the CRT
response rate at 6 months in patients implanted with a CRT device with
the MPP feature activated early after the implant. METHODS This
was a multicentre, prospective, open-label and non-randomized study. The
primary endpoint was response to biventricular pacing defined as
>15% relative reduction in left ventricular end-systolic
volume (LVESV) comparing echocardiography measurements performed at
baseline and 6 months by a core laboratory. Among secondary endpoints
the combined endpoint of mortality or all-cause hospitalizations was
evaluated. Primary study endpoint and clinical outcomes were compared to
a Quarto II control cohort. RESULTS: 105 patients were
included. The response rate was 64.6% (97.5% lower confidence bound
53%). Mean relative reduction in LVESV was 25.3% and mean absolute
increase in LVEF was 9.4%. The subjects with device programmed using
anatomical approach had showed a trend toward higher responder rate than
those using the electrical approach (72% vs. 61.1%, p= 0.32). Compared
with Quarto II, the combined endpoint of mortality and or all-cause
hospitalizations was lower in Quarto III (12.4% vs 25.4%, p=0.004).
CONCLUSIONS: Early activation of MPP was not associated to an
advantage increasing echocardiography responders to CRT at 6 months of
follow up. Nevertheless, MPP was associated with better clinical
outcomes in comparison to a historical control cohort. Patients
programmed using widest pacing cathodes had a numerically higher
responder rate.
Identification of a novel Neorickettsia species in a Kemp's ridley sea turtle with granulomatous nephritis and development of a quantitative PCR assay
Authors: Wellehan James F.X. , Liguori Brittany L. , Stacy Brian A. , Fischer Peter U. , Fischer Kerstin , Archer Linda L. , Childress April L. , Shaver Donna J. , Kariyawasam Subhashinie
Published: August 2022

An adult male Kemp’s ridley was found dead on the coast of Kenedy
County, Texas in August 2019 with bilateral severe, diffuse
granulomatous nephritis. Pan-bacterial 16S rRNA gene PCR and amplicon
sequencing of affected tissue indicated the presence of a
Neorickettsia. Neorickettsia is a genus of obligate
intracellular Alphaproteobacteria that are transmitted by digenean
trematodes. For further characterization, primers were designed to
amplify and sequence the groEL gene. Phylogenetic analysis found
that the organism was distinct from other known species to a degree
consistent with a novel species. Immunohistochemistry using an antibody
directed against a Neorickettsia surface protein showed bacterial
clusters within the renal granulomas. A species-specific quantitative
PCR was designed, and detected the organism within the liver and colon
of the index case. A qPCR survey of grossly normal kidneys
opportunistically collected from additional stranded sea turtle kidneys
detected this organism in five of 15 Kemp’s ridley turtles, two of nine
green turtles, and neither of two loggerhead turtles. Recognition of
this novel organism in an endangered species is concerning; additional
work is underway to further characterize the potential of this organism
as a pathogen of sea turtles.
Pristinamycin induced Toxic epidermal necrolysis (TEN): A case report
Authors: ouni bouraoui , Mansour Khadija , Slim Raoudha , Abdessayed Nihed , Bensayed Nesrine , Barka Malek , Fathallah Neila
Published: August 2022

We report a case of TEN probably related to Pristinamycin
Differential inclusion obstacle problems with variable exponents and convection terms
Authors: Ge Bin , Pucci Patrizia
Published: August 2022

The elliptic obstacle problems with variable exponents and multivalued
reaction terms, depending on the gradient, are considered in this paper.
Under general assumptions on the convection term, we prove two existence
theorems of a (weak) nontrivial solution by using the surjective theorem
and the Leray-Schauder fixed point theorem for multivalued mappings,
respectively. Our assumptions are suitable and different from those
required in the previous literature.
Immune Escape of Bovine Parvovirus by VP1 Inhibiting IFN-β Production through RIG-I like Receptors Pathway
Authors: wei suocheng , gong zhuandi , Yuan zhaofang , Pei Mengyuan , Li dianyu
Published: August 2022

Objective The present study aimed to explore if bovine parvovirus (BPV)
impacts beta interferon (IFN-β) production and to reveal further
molecular mechanism of BPV immune escape. Method The pCMV-Myc-BPV-VP1
recombinant plasmid was verified with both double enzyme digestion and
sequence. HEK 293T cells were transfected with this recombinant protein,
then infected with the vesicular stomatitis virus (VSV). Expression
levels of IFN-β mRNA were detected using qPCR. Results Expression level
of BPV VP1 mRNA in pCMV-Myc-BPV-VP1 group was significantly higher than
those of the untreated group (UT) and pCMV-Myc vector group. BPV virus
copies in bovine turbinate (BT) cells of BPV-VP1 group were raised
(P<0.05) with an increment of 5.8×104. Expression levels of
IFN-β mRNA of BPV VP1 group in HEK 293T cells were decreased
(P<0.01). Following treatment of TBK1 and IRF3(5D), IFN-β
expression levels in HEK 293T cells were depressed. Expression levels of
TBK1, IRF3(5D), MDA5 and MAVS were lower than those of their self
treatment. Conclusion pCMV-Myc-BPV-VP1 could heighten transcription
levels of VP1 protein in BT cells, promote BPV proliferation and ascend
the production of IFN-β. Overexpression of pCMV-Myc-BPV-VP decreased
IFN-β mRNA expression in HEK 293T cells and inhibited IFN-β production
induced by TBK1 and IRF3(5D). Furthermore, BPV VP1 obviously declined
expression levels of TBK1, IRF3(5D), MDA5 and MAVS in RLR pathway. Our
findings revealed a new mechanism evolved by BPV VP1 to inhibit type I
IFN production and provided a solid basis into the immunosuppression of
BPV, which is beneficial for developing novel strategy oftherapy of BPV
disease.
Role of Interventional Radiology in Obstetrics and Gynaecology: A Retrospective review based on an experience in a Quaternary Care Centre.
Authors: BIDARAHALLI SUGUNA , S Arjun , Jayaram Surya , Kurup Mayadevi , Jayakrishnan Vijay
Published: August 2022

Objective: The study aims to equip the Obstetrician and Gynaecologist
with the knowledge of clinical conditions that will benefit from
interventional radiology, the equipment and materials that are commonly
used the benefits and the complications and side effects of these
techniques. Design :A single centre, retrospective cohort study
Population. All obstetric and gynecological cases in which
interventional radiology techniques were used Methods: Review article
with examples from hospital practice from 2015 to 2021 acquired through
computerized database Statistical Analysis: No statistical analysis of
data was required as it was a single Centre retrospective analysis of
cases. Outcome: We had a total of 35 cases, including but not limited to
placenta accreta spectrum disorders ,fibroid,pelvic congestion syndrome
and arteriovenous malformation ,who underwent various interventional
radiological procedures ranging from embolization of uterine artery,
peripheral angiography and embolization ,internal iliac artery balloon
placement to ovarian vein embolization and coil insertion . Conclusion:
Increased collaborative efforts between interventional radiology and
gynaecology would allow for patients to be fully informed on the
complete spectrum of surgical and nonsurgical treatment options
available to them. Tweetable abstract: Evolving role of interventional
radiology in obstetrics and gynaecology
Tenofovir alafenamide alleviates nonalcoholic steatohepatitis in mice by blocking the phosphorylation of AKT in intrahepatic mononuclear phagocytes
Authors: Roh Pu Reun , Kim Sung Min , Kang Byung-Yoon , Mun Kyoung Do , Park Jong Geun , Kang Min Woo , Han Ji Won , Nam Heechul , yoon seung kew , Sung Pil Soo
Published: August 2022

Background and Purpose: Although the prevalence of nonalcoholic
steatohepatitis (NASH) is rapidly increasing, effective therapy is
lacking. Tenofovir alafenamide (TAF) is a widely used antiviral drug for
hepatitis B. In this study, we investigated the potential
pharmacological effects of TAF on NASH. Experimental Approach: Two
different NASH mouse models were established: 1) by subcutaneous
injection of streptozotocin (0.2 mg) and feeding the mice a high-fat,
high-cholesterol (HFHC) diet, and 2) feeding the mice a
choline-deficient, L-amino acid-defined, high-fat (CDAHF) diet. Key
Results: Serum alanine aminotransferase and triglyceride levels in
TAF-treated NASH mice were significantly lower than those in the
mock-treated ones. The livers from the TAF-treated NASH mice showed
attenuated mononuclear phagocyte (MP) infiltration compared to those
from the mock-treated ones. TAF-treated NASH mice exhibited decreased
liver infiltration of activated MPs (IAIE+/PD-L1+/MerTK+). In ex vivo
experiments using sorted human CD14+ monocytes treated with
lipopolysaccharide (LPS) and/or TAF, we confirmed the decreased level of
phosphorylated AKT in TAF-treated LPS-stimulated monocytes compared to
that in the mock-treated ones. Mouse liver immunoblotting showed that
phosphorylation levels of AKT were significantly lower in the
TAF-treated NASH group than in the mock-treated group. Conclusion and
Implications: TAF exerts anti-inflammatory effects in NASH livers by
attenuating AKT phosphorylation in intrahepatic activated MPs.
Therefore, TAF may serve as a new therapeutic option for NASH.
Rituximab-induced severe acute thrombocytopenia in a patient with splenic marginal zone lymphoma
Authors: Kars Taha Ulutan , Yorgancı Zahit Furkan , Yaşkıran Osman , Tekinalp Atakan , Demircioğlu Sinan
Published: August 2022

Introduction: Rituximab, which is widely used in the treatment of B-cell
lymphoma, is a chimeric monoclonal antibody directed against the CD20
antigen. Rituximab has many side effects, mainly allergic and
neurological. Rituximab may cause thrombocytopenia in the long term
after administration. Rare cases with rituximab-induced acute
thrombocytopenia have been reported in the literature. Case Report: A
51-year-old female patient who newly diagnosed splenic marginal zone
lymphoma recieved rituximab as first line therapy. Petechiae occurred in
the lower extremities on the day following rituximab administration. The
blood test showed a severe drop in the platelet count from 112,000/μL to
5,000/μL. Blood peripheral smear evaluation confirmed severe
thrombocytopenia. Management and outcome: There was no change in
hemoglobin or white blood cell levels. After the diagnosis of
rituximab-induced acute thrombocytopenia, thrombocyte suspension was
administered due to the risk of bleeding. Close clinical and laboratory
observations were made. The platelet count began to rise gradually in
the following period. Before the second week of rituximab
administration, the platelet count was 122,000/μL. No complications
developed after premedication and slow rituximab administration, and
subsequent treatments were continued in the same way. Discussion:
Rituximab has a widespread use, especially in malignancies and
autoimmune diseases. Like many monoclonal antibodies, rituximab has
several side effects. Thrombocytopenia is a long-term side effect
associated with rituximab, and rituximab-induced severe acute
thrombocytopenia has been rarely reported. Therefore, it should be kept
in mind that severe acute thrombocytopenia may develop after rituximab
administration.
Analgesic Effect Comparison and Pharmacokinetic Study of Ropivacaine with Different Concentrations in Continuous Serratus Anterior Plane Block in Patients Undergoing Video-Assisted Thoracoscopic Surgery
Authors: chen jieru , chen jiaqi , gao wei , gu hai , chai xiaoqing , wu xianning , Xiao Feng , wang di
Published: August 2022

Aims: The serratus anterior plane block (SAPB) has commonly been
utilized as a regional anesthesia technique for pain management in
various upper chest surgical procedures. The purpose of this study was
to investigate the analgesic effect and pharmacokinetics of ropivacaine
in continuous SAPB undergoing VATS. Methods: This prospective randomized
study included patients scheduled for elective VATS. Patients first
received a bolus of 20 ml of 0.2% (Group L) or 0.375% (Group H)
ropivacaine that was administered beneath the serratus anterior muscle.
The pump was connected to the catheter for continuous administration
within 48 hours postoperatively, in which a background infusion at a
rate of 7 ml·h−1 of low-dose at 0.2% (Group L) or high-dose at 0.375%
(Group H) of ropivacaine was administered. The main results were to
compare the analgesic effects and analyze the pharmacokinetics of
different concentrations of ropivacaine. Results: Eighty-eight patients
agreed to participate in the trial and were recruited. The VAS scores in
Group H at 12, 24, and 48 hours postoperatively at rest and on coughing
were significantly lower than those in Group L. The peak values of total
ropivacaine plasma concentrations were observed at 48 hours (2.01
μg·mL−1 for Group L and 2.93 μg·mL−1 for Group H), which were far below
the theoretical toxicity threshold. Postoperative rescue analgesia,
complications, and other outcomes did not differ significantly.
Conclusions: In VATS patients, the analgesic effect of 0.2% ropivacaine
for continuous SAPB was not inferior to that of 0.375% ropivacaine, and
the blood concentration of 0.2% ropivacaine was
Sarcoid-like reaction in the kidney following rituximab for mantle lymphoma
Authors: mrabet sanda , Fradi Asma , Sahtout Wissal , Azzabi Awatef , Boukadida Raja , Aicha Narjess Ben , Guedri Yosra , Zellama Dorsaf , Achour Abdellatif , Abdessayed Nihed , Mokni Moncef
Published: August 2022

The sarcoid-like reaction is a rare autoinflammatory disease that can
affect lymph nodes or organs but does not meet the diagnostic criteria
for systemic sarcoidosis. Several drug classes have been associated with
the development of a systemic sarcoid-like reaction, which defines
drug-induced sarcoidosis-like reactions and can affect a single organ.
Anti-CD20 antibodies (rituximab) have rarely been reported as
responsible for this reaction and this adverse effect has mainly been
described during the treatment of Hodgkin’s lymphoma. We report a unique
case of a sarcoid-like reaction complicating rituximab following the
treatment of a mantle cell lymphoma and interesting only the kidney. The
60-year-old patient presented with severe acute renal failure six months
after the end of his r-CHOP protocol and the urgent renal biopsy
revealed acute interstitial nephritis rich in granulomas without caseous
necrosis. After ruling out other causes of granulomatous nephritis, a
sarcoid-like reaction was retained since infiltration was limited to the
kidney. The temporal relationship between rituximab administration and
the sarcoid-like reaction onset in our patient supported the diagnosis
of a rituximab-induced sarcoidosis-like reaction. Oral corticosteroid
treatment led to rapid and lasting improvement in renal function.
Clinicians should be warned of this adverse effect and regular and
prolonged monitoring of renal function should be recommended during the
follow-up of patients after the end of treatment with rituximab.
Caries-inhibiting Effect of Microencapsulated Active Components in Pit and Fissure Sealants
Authors: Amend S , Frankenberger R , Lücker S , Krämer N
Published: August 2022

Objective

The aim of the present in vitro study was to examine the caries-inhibiting effect of a pit and fissure sealant (PFS) containing ion-releasing microcapsules under cariogenic conditions in a biofilm artificial mouth.

Methods and Materials

Forty-eight human third molars were divided into four groups (n=12 per group). Fissures were extended with burs and sealed with experimental PFS. The four groups of specimens were treated as follows: 1) EPFS 1: EPFS (Premier Dental) of increasing viscosity, containing microcapsules loaded with remineralizing agents (calcium, phosphate, and fluoride ions); 2) US: fluoride-releasing PFS (UltraSeal XT plus, UltraDent Products, South Jordan, UT, USA); 3) EPFS 2: experimental PFS of constant viscosity containing microcapsules loaded with calcium, phosphate, and fluoride ions; and 4) FT: glass ionomer cement (GIC) (GC Fuji Triage CAPSULE WHITE glass ionomer cement, GC Europe NV, Leuven, Belgium). FT and US were used as control groups. EPFS 1 and EPFS 2 were the experimental groups. Specimens were stored in distilled water for 14 days at 37°C, subjected to 10,000 thermocycles (5°C and 55°C) and finally exposed to microbiological cycling in a Streptococcus mutans-based artificial mouth for 10 days. Replicas were made for scanning electron microscopic (SEM) evaluation and specimens were cut for fluorescence microscopy.

Results

Overall demineralization depths at the margin of Fuji Triage were significantly shallower than in the other groups (p<0.05). Overall demineralization depths adjacent to the experimental pit and fissure sealant EPFS 2 (59±15 μm) were comparable to the values of the resin-based pit and fissure sealant UltraSeal XT plus (58±10 μm, p≥0.05). SEM revealed surface roughness of the GIC-based PFS.

Conclusions

The experimental PFS with microcapsules containing active components for remineralization did not show a caries-inhibiting effect compared to a fluoride-releasing resin-based PFS. Lower demineralization depths adjacent to GIC sealants indicate an anticariogenic effect through fluoride ion release.
Influence of Manganese Oxide on the Esthetic Efficacy and Toxicity Caused by Conventional In-office Tooth Bleaching Therapy
Authors: Ribeiro RAO , de Oliveira Duque CC , Ortecho-Zuta U , Leite ML , Hebling J , Soares DG , de Souza Costa CA
Published: August 2022

Objective

This study aimed to evaluate the esthetic efficacy, cytotoxicity, and kinetics of decomposition of hydrogen peroxide (H2O2) present in a commercial bleaching gel with 35% H2O2 (BG35%) chemically activated with manganese oxide (MnO2).

Methods and Materials

After incorporating 2 mg/mL, 6 mg/mL, and 10 mg/mL of MnO2 into BG35%, the stability of pH and temperature of the products were analyzed. To assess the esthetic efficacy (ΔE and ΔWI), the BG35%s with MnO2 were applied for 45 minutes on enamel/dentin discs (DiE/D). BG35% or no treatment were used as positive (PC) and negative (NC) controls, respectively. To analyze the cell viability (CV) and oxidative stress (OXS), the same bleaching protocols were performed on DiE/D adapted to artificial pulp chambers. The extracts (culture medium + gel components that diffused through the discs) were applied to pulp cells and submitted to H2O2 quantification. BG35% with MnO2 that showed the best results was evaluated relative to kinetic decomposition of H2O2, with consequent generation of free radicals (FR) and hydroxyl radicals (OH•). The data were submitted to the one-way analysis of variance complemented by Tukey post-test (α=0.05). Data on kinetics of H2O2 decomposition were submitted to the Student’s-t test (α=0.05).

Results

All the BG35%s with MnO2 showed stability of pH and temperature, and the gel with 10 mg/mL of this activator had an esthetic efficacy 31% higher than that of the PC (p<0.05). Reduction in OXS and trans-amelodentinal diffusion of H2O2 occurred when all the BG35%s with MnO2 were used. The addition of 6 and 10 mg/mL of MnO2 to BG35% increased the CV in comparison with PC, confirmed by the cell morphology analysis. An increase in FR and OH• formation was observed when 10 mg/mL of MnO2 was added to BG35%.

Conclusion

Catalysis of BG35% with MnO2 minimized the trans-amelodentinal diffusion of H2O2 and toxicity of the product to pulp cells. BG35% containing 10 mg/mL of MnO2 potentiated the decomposition of H2O2, enhancing the generation of FR and OH•, as well as the efficacy of the in-office tooth therapy.
Influence of Irradiance and Exposure Times on the Mechanical and Adhesive Properties of Universal Adhesives with Dentin
Authors: Cardenas AFM , Siqueira FSF , Nuñez A , Nonato RF , Cavalcanti KGBA , Soares CJ , Reis A , Loguercio AD
Published: August 2022

Objectives

This study evaluated the influence of irradiance/exposure time on the Knoop hardness (KHN) and polymer cross-linking density (PCLD), as well as microtensile bond strength (μTBS), nanoleakage (NL), and in situ degree of conversion (DC) of universal adhesives.

Methods and Materials

Two universal adhesive systems, Clearfil Universal Bond Quick (CUQ) and Scotchbond Universal Adhesive (SBU), were light-cured using various irradiance/exposure times: 1400 mW/cm2 for 5 s (1400*5); 1400 mW/cm2 for 10 s (1400*10); 3200 mW/cm2 for 5 s (3200*5); and 3200 mW/cm2 for 10 s (3200*10). Adhesive disks from each group were used to measure PCLD by KHN. One hundred and twenty-eight human molars were randomly assigned to 16 groups according to the following variables: adhesive system vs adhesive strategies vs radiance/exposure times. After restoration, specimens were sectioned into resin-dentin sticks and tested for μTBS, NL, and DC. The data from PCLD (%), KHN, μTBS (MPa), NL (%), and DC (%) data were subjected to ANOVA and Tukey’s test (α=0.05).

Results

Significant reductions in KHN, μTBS, and DC (p=0.00001) values and an increase in NL and PCLD (p=0.00001) values were observed for 3200*10 when compared with other groups. Higher KHN, μTBS, and DC (p=0.000001) values were observed for 3200*5 in comparison with the other groups. The 1400*5 (7 J/cm2) and 1400*10 (14 J/cm2) groups showed intermediate values (p=0.000001).

Conclusion

Although similar results in terms of hardness, polymer cross-linking density and nanoleakage were observed when 5 seconds at 3200 mW/cm2 and 10 seconds at 1400 mW/cm2 groups were compared, the use of higher irradiance (3200 mW/cm2) for only 5 seconds showed better results in terms of bond strength and degree of conversion for both universal adhesives to dentin. The prolonged exposure time (10 seconds) at the higher irradiance (3200 mW/cm2) showed the worst results.
Donne e leadership politica in Iberia
Authors: Escabias Francesca
Published: August 2022

Analizza le strategie dei media in relazione ai ruoli di genere, ai pregiudizi e agli stereotipi sottostanti e all'uso del linguaggio come strumento per costruire un discorso su questi temi.
Data resource profile: children looked after administrative records in Wales
Authors: Allnatt Gemma , Lee Alexandra , Scourfield Jonathan , Elliott Martin , Broadhurst Karen , Griffiths Lucy
Published: August 2022

IntroductionChildren who are 'looked after' by the State are considered one of the most vulnerable groups in society. Being in State care is associated with poor social, educational and health outcomes. Exploring how to improve the system and better support children in care is key to improving these outcomes. When children and young people come to the attention of children's social services a significant amount of information about their care experience is routinely collected by local authorities. In Wales, routine data are captured in the 'Children Looked After' Census which is submitted annually to the Welsh Government and has recently been shared with the Secure Anonymised Information Linkage (SAIL) Databank.
MethodThe aim of this paper is to provide an overview of the main 'Children Looked After' Census dataset and its subsets. These datasets contain rich, situational and individual level data on children looked after, such as information on placement types, education and leaving care. We outline the strengths and limitations of the available information and how to access the data.
ResultsThe 'Children Looked After' Census has recently been made available for research purposes and access to it will enable researchers to explore and understand at population level the journey through the care system and outcomes of leaving care. There is also the opportunity, through the SAIL Databank, for data linkage to health, education and family justice datasets, allowing research to holistically explore other factors associated with being in care.
ConclusionThese data provide a rich source of information about children and young people who have been in care in Wales. They offer researchers opportunities to better understand the care system and outcomes for this within it. Findings will have important implications for making improvements in children's social care policy and practice.
Biden’s China policy
Authors: Rato Vasco
Published: August 2022

Donald Trump upended America’s long-standing, post-Cold war bipartisan China consensus. Initially focused on trade issues, particularly trade imbalances, Administration policy moved toward a more confrontational approach encompassing major security initiatives in the neighborhood. Focusing on the first year of Joe Biden’s China policy, this article seeks to demonstrate the broad continuity between the Biden and Trump Administrations approach to Beijing.
Chinese investment in Portugal and in Italy and its impact in the European Union
Authors: Farrajota Ramos Pedro
Published: August 2022

The debates around Chinese investment and the detrimental effects that it might have on States on the receiving end of it have led the European Union (eu) to pursue initiatives intended to protect the national interests of its countries. The emergence of populism in Italy, together with a growing Euroscepticism and political instability, decisively influenced Italy’s foreign policy on Chinese investmentrelated matters, which led its communication strategies to affect the EU at some points. Alternatively, Portugal’s internal stability and favorable opinion of the eu enabled this country to manage its relations with China while generally taking into account the preservation of the European vector’s stability.
A mãe, a guerreira e a herdeira: a construção da liderança política nas difusas fronteiras entre o público e o privado
Authors: Martins Joyce Miranda Leão , Chaia Vera
Published: August 2022

A modernidade política emerge a partir de contratos sociais excludentes, que relegam à mulher ao espaço privado, devido a supostas sensibilidades, afetos e inclinações ao lar. Partindo do pressuposto que esse imaginário é reproduzido e atualizado, mesmo longe do seu local de origem (o mundo europeu), o trabalho indaga: como se comportam, na disputa eleitoral, as mulheres que reivindicam a participação no espaço público da política? Que estilos de liderança política constroem aquelas das quais não se espera que sejam líderes? O corpus é composto pelas propagandas eleitorais de seis campanhas presidenciais brasileiras, a saber: Heloísa Helena (2006); Dilma Rousseff (2010, 2014); Marina Silva (2010; 2014) e Luciana Genro (2016).  A metodologia utilizada alia análise do discurso à perspectiva de gênero. Reflete-se sobre os resultados encontrados a partir de teorias feministas, concluindo que as estratégias eleitorais promovem o ingresso subordinado das mulheres na política.
Campanhas, meios e estratégias de comunicação: PSoL e REDE Sustentabilidade nas eleições de Jaú em 2016
Authors: Alves Mércia
Published: August 2022

Este artigo discute a organização de campanhas eleitorais nos municípios, da seleção de candidatos e relação entre diretórios às estratégias de comunicação. Para atender a esse objetivo observamos PSoL e REDE em Jaú, o menor município do estado de São Paulo em que há acesso ao HGPE. Entrevistamos os candidatos de ambos os partidos e analisamos a dinâmica financeiras de suas campanhas – total, origem e alocação de recursos. Os resultados mostram que os líderes têm autonomia no planejamento e condução de suas campanhas, que o apoio de simpatizantes e militantes voluntários é central, e a limitação de recursos financeiros é um entrave para uma comunicação instrumental na TV e nas redes sociais.