bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigating Methods to Mitigate Whey Protein Derived Mouthdrying
Authors: Norton Victoria , Lignou Stella , Faka Marianthi , Rodriguez-Garcia Julia , Methven Lisa
Published: September 2021

Mouthdrying is commonly associated with whey protein fortified products. Therefore, mitigating strategies could be key to reducing mouthdrying and maximising the benefits from such products. Currently, few studies have successfully mitigated whey protein derived mouthdrying and this paper aims to investigate different strategies to reduce mouthdrying effects. Accordingly, a series of experiments were carried out with a trained sensory panel (n = 11). Two different whey protein food matrices were tested: (a) whey protein beverages (WPB) varying in lactose (0.05–12.4% w/v) and fat (0.9–7.2% w/v) levels and (b) whey protein fortified snacks: cupcakes with differing whey protein concentrate (WPC) powders (standard and heat-stable) and scones with varying fat content (with and without cream topping). Overall results suggested the tested strategies had limited significant effects on whey protein derived mouthdrying. Increasing lactose (9.4% w/v) in WPBs and fat levels (via cream topping) on scones significantly suppressed mouthdrying. However, all other tested strategies (increasing fat in WPBs and heat-stable WPC in cupcakes) had no significant effect on suppressing perceived mouthdrying. This work demonstrates the challenges with mitigating whey protein derived mouthdrying; however, cross-modal taste suppression and increasing lubrication warrant further investigation.
Approximate Solutions of Nonlinear Partial Differential Equations Using B-Polynomial Bases
Authors: Bhatti Muhammad I. , Rahman Md. Habibur , Dimakis Nicholas
Published: September 2021

A multivariable technique has been incorporated for guesstimating solutions of Nonlinear Partial Differential Equations (NPDE) using bases set of B-Polynomials (B-polys). To approximate the anticipated solution of the NPD equation, a linear product of variable coefficients ai(t) and Bi(x) B-polys has been employed. Additionally, the variable quantities in the anticipated solution are determined using the Galerkin method for minimizing errors. Before the minimization process is to take place, the NPDE is converted into an operational matrix equation which, when inverted, yields values of the undefined coefficients in the expected solution. The nonlinear terms of the NPDE are combined in the operational matrix equation using the initial guess and iterated until converged values of coefficients are obtained. A valid converged solution of NPDE is established when an appropriate degree of B-poly basis is employed, and the initial conditions are imposed on the operational matrix before the inverse is invoked. However, the accuracy of the solution depends on the number of B-polys of a certain degree expressed in multidimensional variables. Four examples of NPDE have been worked out to show the efficacy and accuracy of the two-dimensional B-poly technique. The estimated solutions of the examples are compared with the known exact solutions and an excellent agreement is found between them. In calculating the solutions of the NPD equations, the currently employed technique provides a higher-order precision compared to the finite difference method. The present technique could be readily extended to solving complex partial differential equations in multivariable problems.
Agglutinated Foraminiferal Acmes and Their Role in the Biostratigraphy of the Campanian–Eocene Outer Carpathians
Authors: Waśkowska Anna
Published: September 2021

The biostratigraphy of the Outer Carpathians is based mainly on the ranges of agglutinated foraminifera. Species acmes provide the opportunity to enhance and support the existing biozonations. Assemblages of agglutinated foraminifera from the Campanian to Eocene of various tectonic-structural units were analyzed in terms of their qualitative and quantitative occurrence. In this stratigraphic interval, 19 species display significantly increased abundance within a relatively short interval: Caudammina gigantea (Geroch) (upper Santonian–lowermost Maastrichtian), Caudammina ovulum (Grzybowski) (Campanian–Danian), Placentammina placenta (Grzybowski)-Saccammina grzybowskii (Schubert) (upper Campanian–Danian), Caudammina excelsa (Dylążanka) (lowermost Maastrichtian–Danian), Caudammina ovuloides (Grzybowski) (Danian–Selandian), Hormosina velascoensis (Cushman) (upper Danian–Selandian), Praesphaerammina gerochi (Hanzlíková) (Thanetian), Glomospira charoides (Jones et Parker)-Glomospira gordialis (Jones et Parker) (uppermost Thanetian–lowermost Ypresian), Trochammina spp. (upper Thanetian–lower Ypresian), Reticulophragmium amplectens (Grzybowski) (Lutetian–Bartonian), Reophax duplex (Grzybowski)-Reophax “pilulifer” Brady group of taxa (Lutetian–Priabonian), Haplophragmoides walteri (Grzybowski)-Haplophragmoides nauticus Kender, Kaminski et Jones (Lutetian–Bartonian), Spiroplectammina spectabilis (Grzybowski) (Lutetian–Priabonian), “Ammodiscus” latus Grzybowski (Bartonian–Priabonian), Praesphaerammina subgaleata (Vašíček) (Lutetian–Bartonian). The biostratigraphic position and quantitative data of species with increased abundance are presented.
SART and Individual Trial Mistake Thresholds: Predictive Model for Mobility Decline
Authors: Rizzo Rossella , Knight Silvin Paul , Davis James R. C. , Newman Louise , Duggan Eoin , Kenny Rose Anne , Romero-Ortuno Roman
Published: September 2021

The Sustained Attention to Response Task (SART) has been used to measure neurocognitive functions in older adults. However, simplified average features of this complex dataset may result in loss of primary information and fail to express associations between test performance and clinically meaningful outcomes. Here, we describe a new method to visualise individual trial (raw) information obtained from the SART test, vis-à-vis age, and groups based on mobility status in a large population-based study of ageing in Ireland. A thresholding method, based on the individual trial number of mistakes, was employed to better visualise poorer SART performances, and was statistically validated with binary logistic regression models to predict mobility and cognitive decline after 4 years. Raw SART data were available for 4864 participants aged 50 years and over at baseline. The novel visualisation-derived feature bad performance, indicating the number of SART trials with at least 4 mistakes, was the most significant predictor of mobility decline expressed by the transition from Timed Up-and-Go (TUG) < 12 to TUG ≥ 12 s (OR = 1.29; 95% CI 1.14–1.46; p < 0.001), and the only significant predictor of new falls (OR = 1.11; 95% CI 1.03–1.21; p = 0.011), in models adjusted for multiple covariates. However, no SART-related variables resulted significant for the risk of cognitive decline, expressed by a decrease of ≥2 points in the Mini-Mental State Examination (MMSE) score. This novel multimodal visualisation could help clinicians easily develop clinical hypotheses. A threshold approach to the evaluation of SART performance in older adults may better identify subjects at higher risk of future mobility decline.
Photobiomodulation Therapy vs. Corticosteroid for the Management of Erosive/Ulcerative and Painful Oral Lichen Planus. Assessment of Success Rate during One-Year Follow-Up: A Retrospective Study
Authors: Nammour Samir , El Mobadder Marwan , Brugnera Aldo Jr. , Namour Melanie , Houeis Saad , Heysselaer Daniel , Vanheusden Alain , Namour Amaury
Published: September 2021

Photobiomodulation (PBM) therapy is a promising approach for the management of inflammatory conditions and autoimmune lesions, such as oral lichen planus (OLP). The aim of this retrospective study was to assess the effectiveness of PBM in the management of painful and erosive/ulcerative OLP and to compare it with the standard of care that is the topical application of corticosteroids. 96 patients were included with erosive and painful OLP. 48 patients received PBM therapy and 48 received corticosteroids. Data was collected retrospectively on pain using the visual analogue scale; clinical aspects of lesions were assessed with the REU score, and the recurrence rate was noted. One session of PBM therapy with a helium-neon red light (635 nm) was carried out every 48 h for 6 weeks. Treatments were mainly made in contact mode, using a fiber with a diameter of 600 µm (0.6 mm). The output power of the laser beam was calibrated by a power meter. A delivered power of 0.1 W was used for 40 s in a continuous wave (CW), corresponding to a delivered energy of 4 J. The delivered energy density related to the fiber diameter was 1415 J/cm2. Each treated point was considered as 1 cm2 of diameter. PBM therapy within these parameters was carried out on each point until the totality of the lesion was covered, including the non-erosive OLP area. Furthermore, healthy mucosa within 5 mm of the lesion was also irradiated with the same conditions. This PBM treatment was performed during 6 consecutive weeks. The topical corticosteroid treatment consisted of cortisone application to cover the OLP 3 times/day for 6 weeks. Follow-up was made at 6 weeks and at 3, 6 and 12 months. After 6 weeks, both groups showed complete absence of pain, and a complete disappearance of ulcerative/erosive areas. No significant difference was found for both groups concerning the recurrence rate of erosive OLP during the follow-up period; values were 0% at 6 weeks for both groups and 79% and 87.5% for the corticosteroid and PBM group, respectively, at 12 months of follow-up. PBM is effective for managing OLP and is significantly similar to topical corticosteroids without any need for the use of medication and with no reported side effects.
Impact of Using the Intelligent Physical Health Measurement System on Active Aging: A Survey in Taiwan
Authors: Chi Wen-Chou , Cheng Wei-Chen , Chen Ting-Hung , Lin Po-Jin
Published: September 2021

Background: In Taiwan, the Chiayi City Government and Industrial Development Bureau of the Ministry of Economic Affairs have worked together to promote smart health management in the community and encourage people to use the intelligent physical health measurement system (IPHMS) with Smart Body Health Measuring Machine. Volunteers help participants in the community to use the IPHMS to ensure that measurements are taken correctly. Objectives: This study aimed to explore volunteers’ satisfaction with using the IPHMS and the effects of the measurement service on the participants’ measurement behavior intention, and further explore the impact on their active aging. Methods: This study used a paper questionnaire to survey both the participants of the measurement service and the community volunteers from March to April 2021. A total of 180 valid responses were collected. Results: The sociodemographic information showed that the volunteers were mostly female, were aged over 61 years old, had received junior college education, had spent less than 3–6 years in community service, and had 6 months to 1 year of measured service experience. Additionally, the participants of the measurement service were mostly female, were aged over 61 years old, had received below middle school education, had spent less than 1–3 years in community service, and spent an average of 5 days in the community each week. Our results showed that the information quality (β = 0.352, p < 0.001) and system quality (β = 0.701, p < 0.001) had significant effects on volunteers’ satisfaction of using the IPHMS. Subjective norms had significant effects on participants’ perceived disease threat (β = 0.347, p < 0.001) and behavior intention of management service (β = 0.701, p < 0.001); furthermore, behavior intention had significant effects on their social participation for active aging (β = 0.430, p < 0.05). Conclusions: Improving the system and information quality is likely to improve volunteers’ satisfaction with the system. Active aging factors only affect social participation, which represents the measurement services promote for social interaction mostly.
Assessment of Precipitation Variability and Trends Based on Satellite Estimations for a Heterogeneous Colombian Region
Authors: Morales-Acuña Enrique , Linero-Cueto Jean R. , Canales Fausto A.
Published: September 2021

Adequate water resources management includes understanding patterns and spatiotemporal variability of precipitation, as this variable is determinant for ecosystems’ stability, food security, and most human activities. Based on satellite estimations validated through ground measurements from 59 meteorological stations, the objective of this study is to evaluate the long-term spatiotemporal variability and trends of the average monthly precipitation in the Magdalena Department, Colombia, for the 1981–2018 period. This heterogeneous region comprises many different ecoregions in its 23,188 km2 area. The analysis of spatial variability allowed for the determination of four different subregions based on the differences in the average values of precipitation and the degree of rainfall variability. The trend analysis indicates that the current rainfall patterns contradict previous estimates of a progressive decrease in annual averages due to climate change in the study region, as most of the department does not exhibit statistically significant trends, except for the Sierra Nevada de Santa Marta area, where this study found reductions between 10 mm yr−1 and 30 mm yr−1. The findings of this study also suggest the existence of some links between precipitation patterns with regional phenomena of climate variability and solar activity.
Estimation of Daily Potential Evapotranspiration in Real-Time from GK2A/AMI Data Using Artificial Neural Network for the Korean Peninsula
Authors: Jang Jae-Cheol , Sohn Eun-Ha , Park Ki-Hong , Lee Soobong
Published: September 2021

Evapotranspiration (ET) is a fundamental factor in energy and hydrologic cycles. Although highly precise in-situ ET monitoring is possible, such data are not always available due to the high spatiotemporal variability in ET. This study estimates daily potential ET (PET) in real-time for the Korean Peninsula, via an artificial neural network (ANN), using data from the GEO-KOMPSAT 2A satellite, which is equipped with an Advanced Meteorological Imager (GK2A/AMI). We also used passive microwave data, numerical weather prediction (NWP) model data, and static data. The ANN-based PET model was trained using data for the period 25 July 2019 to 24 July 2020, and was tested by comparing with in-situ PET for the period 25 July 2020 to 31 July 2021. In terms of accuracy, the PET model performed well, with root-mean-square error (RMSE), bias, and Pearson’s correlation coefficient (R) of 0.649 mm day−1, −0.134 mm day−1, and 0.954, respectively. To examine the efficiency of the GK2A/AMI-derived PET data, we compared it with in-situ ET measured at flux towers and with MODIS PET data. The accuracy of the GK2A/AMI-derived PET, in comparison with the flux tower-measured ET, showed RMSE, bias, and Pearson’s R of 1.730 mm day−1, 1.212 mm day−1, and 0.809, respectively. In comparison with the in-situ PET, the ANN model produced more accurate estimates than the MODIS data, indicating that it is more locally optimized for the Korean Peninsula than MODIS. This study advances the field by applying an ANN approach using GK2A/AMI data and could play an important role in examining hydrologic energy for air-land interactions.
Living Space and Job Prospects and Their Relationship with Subjective Well-Being during COVID-19 Confinement in Spain: The Mediator Role of Resilience
Authors: Molero Fernando , Recio Patricia , Sarriá Encarnación
Published: September 2021

The objective of this study was to examine the relationships of participants’ home characteristics (living space) and job prospects after the coronavirus disease 2019 (COVID-19) pandemic to their subjective psychological well-being (SWB) (in terms of both affective and cognitive aspects). We also examined the role of participants’ resilience as a possible mediator in the relationships among the aforementioned variables. The sample comprised 474 Spanish adults who completed an online questionnaire between 14 and 24 April 2020, when COVID-19 confinement was very strict in Spain. We proposed a path analysis model including the described variables. The model presented a good fit (χ2 = 7.41, df = 5, p = 0.376, comparative fit index = 0.996, Tucker–Lewis index = 0.987; root mean square error of approximation = 0.032). The results indicated that living space and future job prospects predicted resilience, which, in turn, was related to SWB. Moreover, the bootstrapping results revealed a mediating effect of resilience that showed indirect relationships between living space and SWB and between job prospects and SWB. Our results underline the importance of environmental (living space) and job-related variables to predict SWB as well as the mediating role that resilience may play during the confinement period.
Incidence of Attention Deficit Hyperactivity Disorder (ADHD) Diagnoses in Navarre (Spain) from 2003 to 2019
Authors: Leache Leire , Arrizibita Olast , Gutiérrez-Valencia Marta , Saiz Luis Carlos , Erviti Juan , Librero Julián
Published: September 2021

(1) Background: Attention deficit hyperactivity disorder (ADHD) constitutes one of the leading mental health and behavioral disorders in childhood and adolescence. The main objective of this study was to analyze the time trend in the incidence of ADHD diagnoses in Navarre (Spain) from 2003 to 2019 in children and adolescents from 5 to 19 years old. Additionally, the seasonal trends of ADHD incidence and ADHD prevalence were determined. (2) Methods: A population-based observational retrospective study, which included people born between 1991 and 2011 and who attended compulsory education between 2007 and 2017 in Navarre (Spain), was carried out with data from both the Education and Health Department databases. (3) Results: The incidence rate increased from 4.18 cases per 1000 person-years in 2003 to 7.43 cases per 1000 person-years in 2009, before decreasing progressively to 2.1 cases per 1000 person-years in 2019. A peak incidence rate at 7–8 years of age was observed, which is consistent across the study period and for both genders. Males were more than twice as likely to be diagnosed with ADHD than females, with similar time trends in both. A seasonal pattern in ADHD diagnosis was found, with peaks in February–March and the lowest rates in the summer months. Inattentive cases were much more frequent than hyperactive cases, whereas combined cases remained low across the study period. (4) Conclusions: In this age-period-cohort analysis, a clear period and age effect was observed. We found a decreasing trend in the ADHD incidence rate since 2015. Further research is needed to confirm whether a change of trend is occurring globally.
Missing In-Center Hemodialysis Sessions among Patients with End Stage Renal Disease in Banda Aceh, Indonesia
Authors: Liu Michael Wei-Chih , Syukri Maimun , Abdullah Abdullah , Chien Li-Yin
Published: September 2021

Indonesian universal health coverage was implemented in 2013 and hemodialysis services became universally accessible, yet few studies have examined patient adherence to hemodialysis schedules. We examined the rates of missed in-center hemodialysis sessions in Banda Aceh and the factors associated with non-attendance. This cross-sectional questionnaire survey included 193 patients receiving in-center hemodialysis. Approximately 28% of the patients missed ≥ 1 hemodialysis session in the month prior to the questionnaire’s administration. About 65% reported attending religious activities as the reason for missing hemodialysis. The level of health literacy was generally low with a mean score of 14.38 out of 26 (55.3%). Multivariate logistic regression analyses showed that patients with educational levels higher than elementary school were less likely to miss hemodialysis sessions. Participants who performed more self-care behaviors had lower odds of missing hemodialysis sessions. Every unit increase in the health literacy score was associated with increased odds of missing hemodialysis sessions. Emphasizing the importance of attending hemodialysis sessions and modifying hemodialysis schedules based on patients’ needs is essential. Patients who miss hemodialysis sessions should be reminded of all self-care behaviors. Health literacy among hemodialysis patients should be improved, with emphasis on patient safety, advanced knowledge, and critical health literacy.
Modifiable Factors for the Trajectory of Health-Related Quality of Life among Youth Growing Up in Poverty: A Prospective Cohort Study
Authors: Chan Ko Ling , Lo Camilla Kin Ming , Ho Frederick K. , Chen Qiqi , Chen Mengtong , Ip Patrick
Published: September 2021

Poverty is a decisive risk factor for poor health and well-being, and its negative consequences could be more severe and substantial among children. Understanding the factors associated with improvement in well-being is vital to design interventions. This is a prospective cohort study of 546 youth growing up in families in poverty in Hong Kong. All participants were assessed twice, in 2016 and 2019, in regard to their physical and mental health, as well as for different economic, social, and psychological variables. The results show that approximately 41% experienced an improvement in their health-related quality of life (HRQoL). Findings from the logistic regression analyses suggest that the health and development of youth in poverty may be restored by promoting social support, a sense of hope, future orientation, job stability, and money management practices, such as savings, during childhood and adolescence. The findings shed light on future policy making and forms of service development that could help to end the vicious cycle of poverty and hampered health.
Corporate Social Responsibility Proposals and Firm Valuation
Authors: Chu Pyung Kun
Published: September 2021

Corporate social responsibility (CSR) is a topic which has recently been attracting an increasing amount of attention with respect to corporate operations, and shareholder proposals on CSR are also one of the main types of proposals at firms’ annual shareholder meetings. However, even though the frequency of CSR proposals at annual meetings is comparable to other types of shareholder proposals, the approval rate of CSR proposals is significantly lower than that of other types of proposals, meaning that most CSR proposals are not recommended by the annual meeting to the board of directors for further approval. Motivated by this stylized fact, this study investigates the value of the submission of CSR shareholder proposals. Using a regression discontinuity design with shareholder proposal data of US public companies between 2006 and 2019, this study examines the importance of shareholders’ interest in CSR for firm valuation. Interestingly, while the CSR proposals themselves are typically not approved, the submission of CSR proposals by shareholders at annual meetings matters for the value impact of other types of shareholder proposals. More specifically, the causal effect of approving a corporate governance proposal on shareholder value is significantly positive only if the corporate governance proposal is voted together with a CSR proposal at the same meeting, i.e., the presence of CSR proposals is important for firm value through its interrelations with corporate governance proposals. This shows that the submission of CSR shareholder proposals has significant value implications, even if the CSR proposals themselves are not approved at annual meetings.
The Effects of Business Model on Bank’s Stability
Authors: Nguyen Thuy Thu , Ho Hai Hong , Nguyen Duy Van , Pham Anh Cam , Nguyen Trang Thu
Published: September 2021

The literature shows little evidence of the effects of business models upon the volatility of banks in developing and fast-growing economies. Hence, this study examines the effects of business model choice on the stability of banks in ASEAN countries. Using GMM and other robust econometric methods on the sample of 99 joint stock commercial banks, we find significant and negative impacts of a diversification model in which banks shift toward non-interest and fees-based activities. We also find that the impacts are different between two groups of countries. For Vietnam, Indonesia and the Philippines, the diversification entails negative impacts on stability while demonstrating positive impacts for Thailand and Malaysia. Based on these findings, we draw policy implications for more sustainable development in the ASEAN banking business.
In Vitro and In Vivo Effects of SerpinA1 on the Modulation of Transthyretin Proteolysis
Authors: Bezerra Filipa , Niemietz Christoph , Schmidt Hartmut H. J. , Zibert Andree , Guo Shuling , Monia Brett P. , Gonçalves Paula , Saraiva Maria João , Almeida Maria Rosário
Published: September 2021

Transthyretin (TTR) proteolysis has been recognized as a complementary mechanism contributing to transthyretin-related amyloidosis (ATTR amyloidosis). Accordingly, amyloid deposits can be composed mainly of full-length TTR or contain a mixture of both cleaved and full-length TTR, particularly in the heart. The fragmentation pattern at Lys48 suggests the involvement of a serine protease, such as plasmin. The most common TTR variant, TTR V30M, is susceptible to plasmin-mediated proteolysis, and the presence of TTR fragments facilitates TTR amyloidogenesis. Recent studies revealed that the serine protease inhibitor, SerpinA1, was differentially expressed in hepatocyte-like cells (HLCs) from ATTR patients. In this work, we evaluated the effects of SerpinA1 on in vitro and in vivo modulation of TTR V30M proteolysis, aggregation, and deposition. We found that plasmin-mediated TTR proteolysis and aggregation are partially inhibited by SerpinA1. Furthermore, in vivo downregulation of SerpinA1 increased TTR levels in mice plasma and deposition in the cardiac tissue of older animals. The presence of TTR fragments was observed in the heart of young and old mice but not in other tissues following SerpinA1 knockdown. Increased proteolytic activity, particularly plasmin activity, was detected in mice plasmas. Overall, our results indicate that SerpinA1 modulates TTR proteolysis and aggregation in vitro and in vivo.
Effects of Metformin on Spontaneous Ca2+ Signals in Cultured Microglia Cells under Normoxic and Hypoxic Conditions
Authors: Jankeviciute Silvija , Svirskiene Natasa , Svirskis Gytis , Borutaite Vilmante
Published: September 2021

Microglial functioning depends on Ca2+ signaling. By using Ca2+ sensitive fluorescence dye, we studied how inhibition of mitochondrial respiration changed spontaneous Ca2+ signals in soma of microglial cells from 5–7-day-old rats grown under normoxic and mild-hypoxic conditions. In microglia under normoxic conditions, metformin or rotenone elevated the rate and the amplitude of Ca2+ signals 10–15 min after drug application. Addition of cyclosporin A, a blocker of mitochondrial permeability transition pore (mPTP), antioxidant trolox, or inositol 1,4,5-trisphosphate receptor (IP3R) blocker caffeine in the presence of rotenone reduced the elevated rate and the amplitude of the signals implying sensitivity to reactive oxygen species (ROS), and involvement of mitochondrial mPTP together with IP3R. Microglial cells exposed to mild hypoxic conditions for 24 h showed elevated rate and increased amplitude of Ca2+ signals. Application of metformin or rotenone but not phenformin before mild hypoxia reduced this elevated rate. Thus, metformin and rotenone had the opposing fast action in normoxia after 10–15 min and the slow action during 24 h mild-hypoxia implying activation of different signaling pathways. The slow action of metformin through inhibition of complex I could stabilize Ca2+ homeostasis after mild hypoxia and could be important for reduction of ischemia-induced microglial activation.
More Than Meets the Eye Regarding Cancer Metabolism
Authors: Kubicka Anna , Matczak Karolina , Łabieniec-Watała Magdalena
Published: September 2021

In spite of the continuous improvement in our knowledge of the nature of cancer, the causes of its formation and the development of new treatment methods, our knowledge is still incomplete. A key issue is the difference in metabolism between normal and cancer cells. The features that distinguish cancer cells from normal cells are the increased proliferation and abnormal differentiation and maturation of these cells, which are due to regulatory changes in the emerging tumour. Normal cells use oxidative phosphorylation (OXPHOS) in the mitochondrion as a major source of energy during division. During OXPHOS, there are 36 ATP molecules produced from one molecule of glucose, in contrast to glycolysis which provides an ATP supply of only two molecules. Although aerobic glucose metabolism is more efficient, metabolism based on intensive glycolysis provides intermediate metabolites necessary for the synthesis of nucleic acids, proteins and lipids, which are in constant high demand due to the intense cell division in cancer. This is the main reason why the cancer cell does not “give up” on glycolysis despite the high demand for energy in the form of ATP. One of the evolving trends in the development of anti-cancer therapies is to exploit differences in the metabolism of normal cells and cancer cells. Currently constructed therapies, based on cell metabolism, focus on the attempt to reprogram the metabolic pathways of the cell in such a manner that it becomes possible to stop unrestrained proliferation.
Effect of Different Subgrid-Scale Models and Inflow Turbulence Conditions on the Boundary Layer Transition in a Transonic Linear Turbine Cascade
Authors: Bertolini Ettore , Pieringer Paul , Sanz Wolfgang
Published: September 2021

The aim of this work is to study the influence of different subgrid-scale (SGS) closure models and inflow turbulence conditions on the boundary layer transition on the suction side of a highly loaded transonic turbine cascade in the presence of high free-stream turbulence using large eddy simulations (LES) of the MUR237 test case. For the numerical simulations, the MUR237 flow case was considered and the incoming free-stream turbulence was reproduced using the synthetic eddy method (SEM). The boundary layer transition on the blade suction side was found to be significantly influenced by the choice of the SGS closure model and the SEM parameters. These two aspects were carefully evaluated in this work. Initially, the influence of three different closure models (Smagorinsky, WALE, and subgrid-scale kinetic energy model) was evaluated. Among them, the WALE SGS closure model performed best compared to the Smagorinsky and KEM models and, for this reason, was used in the following analysis. Finally, different values of the turbulence length scale, eddies density, and inlet turbulence for the SEM were evaluated. As shown by the results, among the different parameters, the choice of the turbulence length scale plays a major role in the transition onset on the blade suction side.
Unsteady Simulation of a Transonic Turbine Stage with Focus on Turbulence Prediction
Authors: Sanz Wolfgang , Scheier David
Published: September 2021

The flow in a transonic turbine stage still poses a high challenge for the correct prediction of turbulence using an eddy viscosity model. Therefore, an unsteady RANS simulation with the k-ω SST model, based on a preceding study of turbulence inlet conditions, was performed to see if this can improve the quality of the flow and turbulence prediction of an experimentally investigated turbine flow. Unsteady Q3D results showed that none of the different turbulence boundary conditions could predict the free-stream turbulence level and the maximum values correctly. Luckily, the influence of the boundary conditions on the velocity field proved to be small. The qualitative prediction of the complex secondary flows is good, but there is lacking agreement in the prediction of turbulence generation and destruction.
Influence of Spanwise and Streamwise Film Hole Spacing on Adiabatic Film Effectiveness for Effusion-Cooled Gas Turbine Blades
Authors: Courtis Matthew , Murray Alexander , Coulton Ben , Ireland Peter , Mayo Ignacio
Published: September 2021

To meet the challenges of increased thermal loads and performance demands on aero-engine turbine blades, more advanced cooling techniques are required. This study used a modification of the well-known Goldstein equation to predict film effectiveness for an individual film cooling hole and applied the Sellers’ superposition method to apply these films across effusion-cooled configurations. In doing so, it tackles a relatively unchallenged problem of film holes in close spanwise proximity. An experimental set-up utilised infrared cameras to assess the film effectiveness of nine geometries of varying spanwise and streamwise spacings. Higher porosity led to increased thermal protection, and the spanwise spacing had the most profound impact, with film effectiveness approaching 0.9. Additionally, greater uniformity in the spanwise direction was observed. The modified Goldstein-Sellers method showed good agreement with experimental results although lateral mixing was underestimated. This method represents a tool that could be easily implemented in the industry for rapid assessment of novel cooling geometries.
Oxidoborates Templated by Cationic Nickel(II) Complexes and Self-Assembled from B(OH)3
Authors: Altahan Mohammed A. , Beckett Michael A. , Coles Simon J. , Horton Peter N.
Published: September 2021

Several oxidoborates, self-assembled from B(OH)3 and templated by cationic Ni(II) coordination compounds, were synthesized by crystallization from aqueous solution. These include the ionic compounds trans-[Ni(NH3)4(H2O)2][B4O5(OH)4].H2O (1), s-[Ni(dien)2][B5O6(OH)4]2 (dien = N-(2-aminoethyl)-1,2-ethanediamine (2), trans-[Ni(dmen)2(H2O)2] [B5O6(OH)4]2.2H2O (dmen = N,N-dimethyl-1,2-diaminoethane) (3), [Ni(HEen)2][B5O6(OH)4]2 (HEen = N-(2-hydroxyethyl)-1,2-diaminoethane) (4), [Ni(AEN)][B5O6(OH)4].H2O (AEN = 1-(3-azapropyl) -2,4-dimethyl-1,5,8-triazaocta-2,4-dienato(1-)) (5), trans-[Ni(dach)2(H2O)2][Ni(dach)2] [B7O9(OH)5]2.4H2O (dach = 1,2-diaminocyclohexane) (6), and the neutral species trans-[Ni(en)(H2O)2{B6O7(OH)6}].H2O (7) (en = 1,2-diaminoethane), and [Ni(dmen)(H2O){B6O7(OH)6}].5H2O (8). Compounds 1–8 were characterized by single-crystal XRD studies and by IR spectroscopy and 2, 4–7 were also characterized by thermal (TGA/DSC) methods and powder XDR studies. The solid-state structures of all compounds show extensive stabilizing H-bond interactions, important for their formation, and also display a range of gross structural features: 1 has an insular tetraborate(2-) anion, 2–5 have insular pentaborate(1-) anions, 6 has an insular heptaborate(2-) anion (‘O+’ isomer), whilst 7 and 8 have hexaborate(2-) anions directly coordinated to their Ni(II) centers, as bidentate or tridentate ligands, respectively. The Ni(II) centers are either octahedral (1–4, 7, 8) or square-planar (5), and compound 6 has both octahedral and square-planar metal geometries present within the structure as a double salt. Magnetic susceptibility measurements were undertaken on all compounds.
Impact of Different Components and Boundary Conditions on the Eigenfrequencies of a Magnet–Girder Assembly
Authors: Andresen Simone
Published: September 2021

Synchrotron radiation facilities are very important in different areas of fundamental and applied science to investigate structures or processes at small scales. Magnet–girder assemblies play a key role for the performance of such accelerator machines. High structural eigenfrequencies of the magnet–girder assemblies are required to assure a sufficient particle beam stability. The objective of the present parametric study was to numerically investigate and quantify the impact of different boundary conditions and components on the magnet–girder eigenfrequencies. As case studies, two 3 m long girder designs following the specifications of the PETRA IV project at DESY (German Electron Synchrotron, Hamburg, Germany) were selected. High magnet–girder assembly eigenfrequencies were achieved by, e.g., positioning the magnets close to the upper girder surface, increasing the connection stiffness between the magnets and the girder and between the girder and the bases, and positioning the girder support points as high as possible in the shape of a large triangle. Comparing the E/ρ ratio (E: Young’s modulus, ρ: material density) of different materials was used as a first approach to evaluate different materials for application to the girder. Based on the findings, general principles are recommended to be considered in the future girder design development processes.
Non-Invasive Indirect Markers of Liver Fibrosis after Interferon-Free Treatment for Hepatitis C
Authors: Przekop Dagmara , Klapaczynski Jakub , Grytczuk Agnieszka , Gruszewska Ewa , Gietka Andrzej , Panasiuk Anatol , Golaszewski Slawomir , Cylwik Bogdan , Chrostek Lech
Published: September 2021

The effectiveness of interferon-free therapy during the course of HCV infection has already been confirmed. Liver fibrosis can be assessed in several ways, from biopsies to imaging tests. The present study evaluates the usefulness of non-invasive indirect biomarkers of liver fibrosis (APRI, GAPRI, FORNS, FIB-4, the AP index and HUI score) as markers of the effective treatment of HCV with the 3D regimen. Blood samples were collected from 70 patients suffering from chronic hepatitis C. Patients received the 3D AbbVie regimen for hepatitis C. All patients had HCV genotype 1b. The APRI, GAPRI, FIB-4, FORNS, HUI and AP index (age–platelet score) values were calculated with their respective algorithms. The stage of fibrosis was evaluated on the basis of a liver biopsy and confirmed by FibroScan-based transient elastography. An undetectable level of HCV RNA after 12 weeks of treatment with the 3D regimen indicates 100% eradication of hepatitis C virus. After the treatment, non-invasive indirect markers of liver fibrosis achieved levels below the limit for significant fibrosis, Thus, non-invasive indirect biomarkers of hepatic fibrosis failed to detect the presence of significant fibrosis, which was proved in histopathological examination. However, the eradication of hepatitis C virus by means of the 3D regimen treatment does not mean that patients were completely cured.
Surface Qualification Toolpath Optimization for Hybrid Manufacturing
Authors: Thien Austen , Saldana Christopher , Kurfess Thomas
Published: September 2021

Hybrid manufacturing machine tools have great potential to revolutionize manufacturing by combining both additive manufacturing (AM) and subtractive manufacturing (SM) processes on the same machine tool. A prominent issue that can occur when going from AM to SM is that the SM process toolpath does not account for geometric discrepancies caused by the previous AM step, which leads to increased production times and tool wear, particularly when wire-based directed energy deposition (DED) is used as the AM process. This work discusses a methodology for approximating a part’s surface topology using on-machine contact probing and formulating an optimized SM toolpath using the surface topology approximation. Three different geometric surface approximations were used: triangular, trapezoidal, and a hybrid of both. SM toolpaths were created using each geometric approximation and assessed according to three objectives: reducing total machining time, reducing surface roughness, and reducing cutting force. Different prioritization scenarios of the optimization goals were also investigated. The optimal surface approximation that yielded the most improvement in the optimization was determined to be the hybrid surface topology approximation. Furthermore, it was shown that when the machining time or cutting force optimization goals were prioritized, there was little improvement in the other optimization goals.
Evolution and Prediction of Landscape Patterns in the Qinghai Lake Basin
Authors: Han Yanli , Yu Deyong , Chen Kelong
Published: September 2021

The Qinghai Lake Basin (QLB), located in the northeastern part of the Qinghai–Tibet Plateau, has a fragile ecological environment and is sensitive to global climate change. With the progress of societal and economic development, the tourism industry in the QLB has also developed rapidly, which is bound to result in great changes in landscape patterns. In this study, we first analyzed the change characteristics of landscape patterns in the QLB from 1990 to 2018, and we then used the Markov model and the future land use simulation (FLUS) model, combined with natural, social, and ecological factors, to predict the changes in the number and spatial distribution of landscape patterns in the period between 2026 and 2034. The results of the study show that desert areas have been greatly reduced and transformed into grasslands. The grassland area expanded from 49.22% in 1990 to 59.45% in 2018, corresponding to an increase of 10.23%. The direct cause of this result is the combined effects of natural and man-made factors, with the latter playing a leading role. As such, government decision-making is crucial. Lastly, we simulated the landscape patterns in the period from 2018 to 2034. The results show that in the next 16 years, the proportion of various landscapes will change little, and the spatial distribution will be stable. This research provides a reference for the formulation of ecological environment management and protection policies in the QLB.
Digital Transformation and Artificial Intelligence Applied to Business: Legal Regulations, Economic Impact and Perspective
Authors: Reier Forradellas Ricardo Francisco , Garay Gallastegui Luis Miguel
Published: September 2021

Digital transformation can be defined as the integration of new technologies into all areas of a company. This technological integration will ultimately imply a need to transform traditional business models. Similarly, artificial intelligence has been one of the most disruptive technologies of recent decades, with a high potential impact on business and people. Cognitive approaches that simulate both human behavior and thinking are leading to advanced analytical models that help companies to boost sales and customer engagement, improve their operational efficiency, improve their services and, in short, generate new relevant information from data. These decision-making models are based on descriptive, predictive and prescriptive analytics. This necessitates the existence of a legal framework that regulates all digital changes with uniformity between countries and helps a proper digital transformation process under a clear regulation. On the other hand, it is essential that this digital disruption is not slowed down by the regulatory framework. This work will demonstrate that AI and digital transformation will be an intrinsic part of many applications and will therefore be universally deployed. However, this implementation will have to be done under common regulations and in line with the new reality.
3D Printing—A Cutting Edge Technology for Treating Post-Infarction Patients
Authors: Cernica Daniel , Benedek Imre , Polexa Stefania , Tolescu Cosmin , Benedek Theodora
Published: September 2021

The increasing complexity of cardiovascular interventions requires advanced peri-procedural imaging and tailored treatment. Three-dimensional printing technology represents one of the most significant advances in the field of cardiac imaging, interventional cardiology or cardiovascular surgery. Patient-specific models may provide substantial information on intervention planning in complex cardiovascular diseases, and volumetric medical imaging from CT or MRI can be translated into patient-specific 3D models using advanced post-processing applications. 3D printing and additive manufacturing have a great variety of clinical applications targeting anatomy, implants and devices, assisting optimal interventional treatment and post-interventional evaluation. Although the 3D printing technology still lacks scientific evidence, its benefits have been shown in structural heart diseases as well as for treatment of complex arrhythmias and corrective surgery interventions. Recent development has enabled transformation of conventional 3D printing into complex 3D functional living tissues contributing to regenerative medicine through engineered bionic materials such hydrogels, cell suspensions or matrix components. This review aims to present the most recent clinical applications of 3D printing in cardiovascular medicine, highlighting also the potential for future development of this revolutionary technology in the medical field.
Synthesis of a Lubricant to Mimic the Biorheological Behavior of Osteoarthritic and Revision Synovial Fluid
Authors: Herbster Maria , Nizinkovskyi Rostyslav , Bollmann Miriam , Bartel Dirk , Lohmann Christoph H. , Krüger Manja , Halle Thorsten , Bertrand Jessica
Published: September 2021

The rheological properties of synovial fluid (SF) are essential for the friction behavior and wear performance of total joint replacements. Standardized in vitro wear tests for endoprosthesis recommend diluted calf serum, which exhibits substantial different rheological properties compared to SF. Therefore, the in vitro test conditions do not mimic the in vivo conditions. SF samples from osteoarthritis knee patients and patients undergoing knee endoprosthesis revision surgery were compared biochemically and rheologically. The flow properties of SF samples were compared to synthetic fluid constituents, such as bovine serum albumin (BSA) and hyaluronic acid (HA). Interestingly, HA was identified as a significant contributor to shear-thinning. Using the acquired data and mathematical modelling, the flow behavior of human SF was modelled reliably by an adapted adjustment of biorelevant fluid components. Friction tests in a hard/soft bearing (ceramic/UHMWPE) demonstrated that, in contrast to serum, the synthetic model fluids generate a more realistic friction condition. The developed model for an SF mimicking lubricant is recommended for in vitro wear tests of endoprostheses. Furthermore, the results highlight that simulator tests should be performed with a modified lubricant considering an addition of HA for clinically relevant lubrication conditions.
Radiation Hardness of Silicon Carbide upon High-Temperature Electron and Proton Irradiation
Authors: Lebedev Alexander A. , Kozlovski Vitali V. , Davydovskaya Klavdia S. , Levinshtein Mikhail E.
Published: September 2021

The radiation hardness of silicon carbide with respect to electron and proton irradiation and its dependence on the irradiation temperature are analyzed. It is shown that the main mechanism of SiC compensation is the formation of deep acceptor levels. With increasing the irradiation temperature, the probability of the formation of these centers decreases, and they are partly annealed out. As a result, the carrier removal rate in SiC becomes ~6 orders of magnitude lower in the case of irradiation at 500 °C. Once again, this proves that silicon carbide is promising as a material for high-temperature electronics devices.