bluuebunny/crossref_metadata_2025 huggingface dataset:
Introduction to Diseña 22: Design, Oppression, and Liberation (2nd issue)
Authors:   Universidade Tecnológica Federal do Paraná, van Amstel Frederick M. C. , Freese Gonzatto Rodrigo ,   Pontifícia Universidade Católica do Paraná, Noel Lesley-Ann ,   North Carolina State University
Published: March 2023

This special edition introduces eight papers at the intersec­tion of design, oppression, and liberation. These papers refer to social struc­ture as a common leverage point to criticize and transform different oppres­sion relations, namely racism, gender, marginalization, epistemic injustice, and colonization. The contributions follow recent moves in social movements and social sciences that recognize that tackling different oppression relations enables seeing oppressive structures more clearly. Nurturing solidarity bonds across different oppression struggles becomes an urgent task in this new field of research we call Oppression Studies of Design. Building upon anti-colonial views on oppression, this field connects design research with the history of changing social structures through liberation struggles.
Una revisión sobre Lean Construction para la Gestión de Proyectos de Construcción
Authors: Garcés G. , Peña C.
Published: March 2023

La industria de la construcción es una parte importante del sector económico de un país, por lo que es importante verificar los nuevos sistemas de gestión que se implementan en las principales industrias de la construcción del mundo. Este artículo hace una revisión bibliográfica de la filosofía Lean Construction (LC), introducida por el profesor Lauri Koskela en 1992, a partir del modelo utilizado por la industria del automóvil en los años 80, denominado “Lean Production”. Las bases teóricas de LC pretenden ver la producción en construcción como un proceso de transformación, flujo y generador de valor, en consecuencia, el objetivo de Lean Construction es crear buenos sistemas de producción que permitan optimizar, reducir o eliminar flujos para mejorar los tiempos de entrega. En el marco de la creación de herramientas Lean para mejorar la gestión de proyectos de construcción, surge el Last Planner System para mejorar el proceso de programación de obra y el modelo Integrated Project Delivery (IPD), que al unificarlo con LC se convierte en Lean Project Delivery System (LPDS), que propone la metodología para desarrollar proyectos de construcción en cinco fases y 12 etapas “Lean”, en las que se desarrollan herramientas que contribuyan a la generación de valor. Finalmente, la tecnología de modelado 3D Building Information Modeling (BIM), aunque no es parte de LC, es una importante herramienta de ayuda para el modelo LPDS, ayudando a comprender mejor los procesos de construcción de diseños complejos para ahorrar tiempo en su construcción. Bajo este paradigma, el surgimiento de nuevas herramientas nos da una mejor visión del futuro de la Lean Construction.
The Impact of Professional Development on the Pedagogical Content Knowledge of the Mathematics Teacher
Authors: Adams Alfred Kofi , Asemnor Felix , Nkansah Vincential , Adonu Harrison
Published: March 2023

Aim: The study Sought to explore the impact of professional development on the pedagogical content knowledge of the mathematics teacher in Ghana.

Study Design: The study used a case study research design.

Methodology: Three research instruments, namely; documents, interview and semi-structured open-ended questionnaires was used for the study. Twelve (12) teachers were sampled from a teacher population of forty-eight (48) mathematics teachers from nine (9) government assisted Senior High Schools in the Keta Municipality to respond to the questionnaire, while a Deputy Director of Education was interviewed to gather qualitative data for analysis.

Results: This research study identified that professional development had positive impacts on the Pedagogical Content Knowledge of mathematics teachers.

These findings imply that, professional development for teachers is important to ensure effective teaching for improved performance of students in mathematics.

Conclusions: Teachers were of the view that they should be included in the planning process of the professional development programmes, realistic duration for the programmes, they also suggested teacher motivation for participation, called for consistency in the organization of the programmes, follow-up programmes and also provision of adequate learning materials.
Effect of Different Trichoderma asperellum Formulations on Management of Sheath Blight of Rice
Authors: Datta Diptanu , Senapati Akshaya Kumar , Panda Arya Gautam Panda , Boblina Bulbul , Mishra Mihira Kumara , Srinivas P. , Samantaray Deviprasad , Dey Prajjal , Saha Debanjana
Published: March 2023

Trichoderma spp. were known to have antagonistic activity against against many soil borne diseases. In this experiment we have prepared five different formulations of Trichoderma asperellum and stored them in normal temperature. Later the efficacy of all the formulations were checked against sheath blight disease of rice both in-vitro and in-vivo. Among formulations the F5 [Trichoderma grown in potato dextrose broth (500ml) + Talc(500g)] treated plants showed very good result in managing sheath blight of rice by enhancing the plant height, total number of filled grains and root length. All the formulations performed significantly better than untreated control plants. The F5 treated plants were also recorded to have less disease incidence with increased yield as compared to other formulations.
Response of Early, Timely & Late Genotypes of Brassica sps. Grown under Different Temperature Conditions for Oil Content & Fatty Acid Composition
Authors: Singh Sumeet Kumar , Chakrabarty S. K. , Kumar Manoj , Prakash Krishna , Kumari Sarita
Published: March 2023

The effect of four different dates of sowing on oil content and fatty acid composition was studied using eleven rapeseed and Indian mustard varieties at Indian Agricultural Research Institute, New Delhi. Effects of species, maturity duration (early, timely and late sown) and environment (different dates of sowing) on the oil content and fatty acid composition was observed. The results indicate specific, genotypic variation as well as different response to the environment, resulting from strong G×E interactions for oil content and delay in sowing compromised the oil content in general. Higher temperature at seed filling and pod maturity stage affected the fatty acid profile. A significant correlation between temperature variables at maturity and fatty acid composition was observed. Linolenic (r= -0.335 to -0.317) and erucic acid (r = -0.578 to -0.568) was significantly and negatively correlated with temperature at maturity stage whereas a positive correlation was found with linoleic acid content (r = 0.324 to 0.338). The results indicated that the sowing of brassica genotypes during 2nd fortnight of October is beneficial as far as the oil content as well as oil quality is concerned.
Biometric Data Changes after Penetrating Corneal Wounds in Pediatric Eyes
Authors: Samir Sara Ashraf , Sharaf Amr Fawzy , El Seht Rabab Mohamed , Ghoniem Ahmed Mohamed
Published: March 2023

Background: Traumatic cataract accounts for a large proportion of monocular visual disability and blindness in pediatric populations, especially in developing countries. This study aims to evaluate the axial length and other biometric data changes after penetrating corneal wound in pediatric eyes.

Methods: This is a prospective comparative control study carried on thirty children with unilateral penetrating ocular trauma associated with cataract. Patients were classified into 3 groups: Group A (n= 15 eyes) underwent cataract extraction and IOL implantation in same session 6 weeks after trauma, Group B (n= 15 eyes) underwent cataract extraction, and IOL implantation in second session 3 months after trauma and the third one is the control group with 30 contralateral eyes of both groups

Results: Regarding axial length, measures were reported to be was (22.882 ± 0.712) mm in group (A) after 6 weeks from the incidence of trauma, while in group (B) it was (22.568 ± 0.881) mm. P-value was insignificant (0.292). After 12 weeks, mean AL in group A was reported to be 23.199 ± 0.724) mm while in group B it was (22.903 ± 1.008) mm with insignificant p value as well (0.362). After 6 weeks, the mean K-readings for group A were found to be 41.184 ± 2.109 while group B were (42.928 ± 2.433). After 12 weeks, the mean K-readings for group A were 41.491 ± 1.729 while group B were (42.797 ± 2.518).

Conclusion: Early I/A and anterior vitrectomy recommended for cases with free lens in AC for fear of reaction, while IOL implantation is recommended to wait after stitches removal.
The large group as a transformational space
Authors: Solomon Margot
Published: March 2023

This paper explores the process of a large group- from my experience as both a participant and conductor; and using my artwork as a way to facilitate my understanding. I attempt to articulate what is implicit to large groups and is difficult for the individually-focused mind to comprehend. I have approached my paper from the inside out. I have thought about the process of the large group from inside of me: what I sense, feel, and experience in a large group. Then, through images that I have made and through Māori mythology, I have explored some ways of attempting to make sense, to understand and make meaning.
Large groups can be a means to better understand and learn to engage in the conscious and unconscious processes that affect us and control us all in large group settings. Inside the large group many or all of the elements of an organisation, or even a culture, already exist that offer us the potential means to begin to engage in more of the whole picture of human life. Large groups can help us to think about interdisciplinary issues, bi-cultural and multicultural issues, political issues, power issues, and all areas where splitting occurs in connection with difference. It is also possible to experience in the large group space a transformation of separate individual consciousness, into a feeling of belonging and community where people can dialogue across their differences.
Virtual living in mixed realities
Authors: Tan Leon
Published: March 2023

Psychoanalysis and psychotherapy as disciplines have been relatively slow in the exploration and analysis of cyberspace phenomena and screen technology mediated subjectivity. This paper takes a tour of five mixed reality scenarios (i.e. where real and virtual spaces mix) so as to stimulate thinking and discussion on the impact of the internet on contemporary populations (at the level of both psyche and socius). It also puts forward the claim that the experiences of virtual living afforded by cyberspace offer unique potentials for the theory and practice of psychotherapy and psychoanalysis today.
Getting in touch
Authors: Wharetohunga King Mihiteria
Published: March 2023

The knowledge and practice of psychotherapy in New Zealand has strong, fiercely protected roots that originate from outside of this land. For most Māori, if they enter into a psychotherapeutic relationship, it will most often be with a Pakeha, or non-Māori practitioner who has gained their theory and understanding of healing the psyche from these 'other' traditions. However, with the shift in consciousness that is occurring here in Aotearoa, there is a genuine growing desire, particularly among psychotherapists, to know more about concepts that are important for Māori, the tangata whenua of Aotearoa, so that these can be understood, appreciated and tentatively integrated into professional practice and personal worldviews. Metge (1986) believes that understanding whakamā is of crucial importance in understanding and improving relations between Māori and Pakeha. This would surely follow through to the therapeutic relationship and it is therefore timely to begin exploring the concept of whakamā in psychotherapy practised here in Aotearoa. The purpose of this paper is to introduce the concept of whakamā and other supporting or associated concepts, and to invite further discussion of whakamā in practice. There has been no attempt to provide a cross-cultural integration or comparison at this point.
The violent mind
Authors: Bryant John
Published: March 2023

This article will discuss the complex interaction of experience and biology in the formation of the violent mind. The practice of psychotherapy reflects the philosophical emphasis of hermeneutic phenomenology upon sensitivity and relationship to lived experience. Phenomenology searches for pre conscious experience. Hermeneutics shapes meaning and gives significance to such phenomena. This commentary emphasises themes of shame, fathering and remorse as they arise from a series of insightful interviews with men about individual experiences of violence. The influences of neurobiology and attachment theory are used to understand the dynamic forces behind these themes and the role that neurobiology and attachment theory play in understanding violence.
What Is Melanoma?
Authors: Wang Jennifer Y. , Wang Erica B. , Swetter Susan M.
Published: March 2023

This JAMA Patient Page describes melanoma, its risk factors, diagnosis, treatment, and prognosis.
Out-of-Pocket Costs of Treatment Among Employer-Insured Women With Invasive Breast Cancer
Authors: Hager Audrey , Gracia Gabriela , Rodin Danielle , Conti Rena M.
Published: March 2023

This cross-sectional study examines out-of-pocket costs for the treatment of invasive breast cancer in employer-insured women younger than 65 years.
Association of Structural Fires in New York City With Inequities in Safe Heating for Immigrant Communities
Authors: Stanton Eloise , Biedry Julia , Rochlin Danielle , Sheckter Clifford C.
Published: March 2023

This cross-sectional study assesses the association of heating complaints with structural fires in New York, New York.
Toward AI assistants that let designers design
Authors: De Peuter Sebastiaan , Oulasvirta Antti , Kaski Samuel
Published: March 2023

We need to rethink how we assist designers with artificial intelligence (AI). AI should aim to cooperate, not automate, by supporting and leveraging the creativity and problem‐solving capabilities of designers. The challenge for such AI is how to infer designers' goals and then help them without being needlessly disruptive. We introduce AI‐assisted design, a new framework for creating such AI, built around generative user models, which allow it to infer and adapt to designers' goals, reasoning, and capabilities.
Profilometry‐Based Indentation Plastometry Testing for Characterization of Case‐Hardened Steels
Authors: Ooi Steve , Reiff-Musgrove Rebecca , Gaiser-Porter Marcus , Steinbacher Matthias , Griffin Ian , Campbell Jimmy , Burley Max , Warwick Marcus , Vaka Harika , Fang Chizhou , Clyne Trevor William
Published: March 2023

An attraction of the profilometry‐based indentation plastometry (PIP) procedure is that, while it involves interrogation of volumes sufficiently large to ensure that bulk properties are obtained, it still allows stress–strain curves to be inferred for relatively small regions, such that local properties can be mapped where they are changing over short distances. It is employed here to obtain these characteristics as a function of depth in samples that have been case hardened by the diffusional penetration of carbon, to a depth of just over a mm. This has been done for a grade of steel that is commonly treated in this way. The thickness of the layer characterized by the PIP test is around 200 μm. In addition, curvature measurements on strip samples, after incremental removal of thin layers, have been used to evaluate the (compressive) residual stresses in near‐surface regions. These range up to around 200 MPa. Such stresses have only a small effect on the PIP measurements. The carburization raises the peak yield stress from the base level of around 1000 MPa to about 1400 MPa, followed by considerable work hardening. The reliability of these PIP‐derived stress–strain relationships has been confirmed by comparing experimental outcomes of Vickers hardness tests with FEM predictions based on their use.
Intrafibrillar Mineralization and Immunomodulatory for Synergetic Enhancement of Bone Regeneration via Calcium Phosphate Nanocluster Scaffold
Authors: Zhou Yanyan , Hu Zihe , Jin Wenjing , Wu Haiyan , Zuo Minghao , Shao Changyu , Lan Yanhua , Shi Yang , Tang Ruikang , Chen Zhuo , Xie Zhijian , Shi Jue
Published: March 2023

Inspired by the bionic mineralization theory, organic–inorganic composites with hydroxyapatite nanorods orderly arranged along collagen fibrils have attracted extensive attention. Planted with an ideal bone scaffold will contribute greatly to the osteogenic microenvironment; however, it remains challenging to develop a biomimetic scaffold with the ability to promote intrafibrillar mineralization and simultaneous regulation of immune microenvironment in situ. To overcome these challenges, a scaffold containing ultra‐small particle size calcium phosphate nanocluster (UsCCP) is prepared, which can enhance bone regeneration through the synergetic effect of intrafibrillar mineralization and immunomodulatory. By efficient infiltration into collagen fibrils, the UsCCP released from the scaffold achieves intrafibrillar mineralization. It also promotes the M2‐type polarization of macrophages, leading to an immune microenvironment with both osteogenic and angiogenic potential. The results confirm that the UsCCP scaffold has both intrafibrillar mineralization and immunomodulatory effects, making it a promising candidate for bone regeneration.
Pure Conducting Polymer Hydrogels Increase Signal‐to‐Noise of Cutaneous Electrodes by Lowering Skin Interface Impedance
Authors: Roubert Martinez Sebastian , Le Floch Paul , Liu Jia , Howe Robert D.
Published: March 2023

Cutaneous electrodes are routinely used for noninvasive electrophysiological sensing of signals from the brain, the heart, and the neuromuscular system. These bioelectronic signals propagate as ionic charge from their sources to the skin–electrode interface where they are then sensed as electronic charge by the instrumentation. However, these signals suffer from low signal‐to‐noise ratio arising from the high impedance at the tissue‐to‐electrode contact interface. This paper reports that soft conductive polymer hydrogels made purely of poly(3,4‐ethylenedioxy‐thiophene) doped with poly(styrene sulfonate) present nearly an order of magnitude decrease in the skin–electrode contact impedance (88%, 82%, and 77% at 10, 100, and 1 kHz, respectively) when compared to clinical electrodes in an ex vivo model that isolates the bioelectrochemical features of a single skin–electrode contact. Integrating these pure soft conductive polymer blocks into an adhesive wearable sensor enables high fidelity bioelectronic signals with higher signal‐to‐noise ratio (average 2.1 dB increase, max 3.4 dB increase) when compared to clinical electrodes across all subjects. The utility of these electrodes is demonstrated in a neural interface application. The conductive polymer hydrogels enable electromyogram‐based velocity control of a robotic arm to complete a pick and place task. This work provides a basis for the characterization and use of conductive polymer hydrogels to better couple human and machine.
Dual‐Frequency Arbitrary‐Plane Multiplexed Holography at Microwave Frequency Bands
Authors: Zhang Qingyuan , Zhang Qiao , Wang Jingwen , Ding Jun , Zhang Hualiang , Chen Weidong , Chen Chang
Published: March 2023

Holography based on optical metasurfaces has attracted a steadily increasing interest. However, most of the optical metasurfaces usually suffer from limited number and fixed viewing angles of multiplexed holography images in one channel. Here, by modifying the Gerchberg–Saxton algorithm, a multiplexed holography at arbitrary‐planes is proposed at two arbitrary microwave frequency bands. As a proof‐of‐concept demonstration, two independent information channels can be established by a single metasurface through dual‐frequency meta‐atoms. The metasurface composed of 35 × 35 meta‐atoms can simultaneously produce four images with 45° and 60° viewing angles at 10 GHz and five images with vertical and horizontal viewing angles at 16 GHz. The experimental results verify the design concept, making it possible to generate multiplexed holography in arbitrary‐planes, and allowing multiplexed functionalities in a variety of applications such as microscopy, display, security, data storage, and information processing.
Strong Nonlinear Optical Response and Transient Symmetry Switch in Type‐II Weyl Semimetal β‐WP2
Authors: Hu Tianchen , Su Bo , Shi Liyu , Wang Zixiao , Yue Li , Xu Shuxiang , Zhang Sijie , Liu Qiaomei , Wu Qiong , Li Rongsheng , Zhou Xinyu , Yuan Jiayu , Wu Dong , Chen Zhiguo , Dong Tao , Wang Nanlin
Published: March 2023

The topological Weyl semimetals (WSMs) with peculiar band structures exhibit novel nonlinear optical enhancement phenomena, even for light at optical wavelengths. While many intriguing nonlinear optical effects are constantly uncovered in type‐I WSMs, few experimental works focuse on basic nonlinear optical properties in type‐II WSMs. Here a static and time‐resolved second harmonic generation (SHG) is performed on the 3D type‐II WSM candidate β‐WP2. Although β‐WP2 exhibits extremely high conductivity and a high carrier density (≈1021 cm−3), the SHG is unscreened by conduction electrons, and a rather strong SHG response is observed, comparing with non‐topological polar metals. Additionally, the time‐resolved SHG experiment traces ultrafast symmetry switch and reveals that polar metal β‐WP2 tends to form an inversion symmetric metastable state after photo‐excitation. Intense femtosecond laser pulse can optically drive symmetry switch and tune nonlinear optical response on ultrafast timescales although the interlayer coupling of β‐WP2 is very strong. These findings are illuminating for the polar metal nonlinear optics and provide a new perspective for future ultrafast topological optoelectronic devices.
Incorporating Meta‐Atom Interactions in Rapid Optimization of Large‐Scale Disordered Metasurfaces Based on Deep Interactive Learning
Authors: Ma Yihan , Kolb Jonas Florentin , Ihalage Achintha Avin , Andy Andre Sarker , Hao Yang
Published: March 2023

Surface symmetry breaking and disorder have been recently explored to overcome operation bandwidth, unwanted diffraction, and polarization dependence issues in the conventional metasurface designs thanks to their increasing degrees of design freedom. However, efficient full‐wave simulation and optimization of electrically large electromagnetic structures have been a longstanding problem. Herein, an interactive learning approach is developed to build new meta‐atom datasets which include the effect of mutual coupling. A deep learning‐based model is developed to extract features of incident/reflection waves and their neighboring interaction responses from a limited number of known meta‐atoms. Finally, the deep neural network is incorporated with optimization algorithms to design, as an example, large‐scale metasurfaces for beam manipulation and wideband scattering reduction. The results demonstrate that the proposed architecture can be successfully applied to rapidly design aperture‐efficient metasurfaces or metalenses at large scales of over tens of thousands of meta‐atoms.
Pixelating Structural Color with Cholesteric Spherical Reflectors
Authors: Agha Hakam , Zhang Yan-Song , Geng Yong , Lagerwall Jan Peter Felix
Published: March 2023

While structural color is a powerful means of obtaining saturated and durable pigments that minimize absorption, scattering, and negative environmental impact, appearing naturally in animals and plants as well as in carefully designed artificial composites, it is fundamentally limited to spectral colors, leaving white and other mixed colors elusive. It also normally suffers from a strong viewing angle dependence, making color definition difficult. Herein, it is demonstrated that these challenges can be overcome by using cholesteric spherical reflectors (CSRs), spheres of polymerized cholesteric liquid crystal with radial alignment of the self‐assembled helical structure. Exhibiting omnidirectional selective retroreflectivity of well‐defined color, CSRs are discrete “packages” of structural color. This allows them to be used as pixels for generating nonspectral colors, following the principle of digital displays. A method of creating densely packed monolayers of CSRs with red (R), green (G), and blue (B) retroreflection is developed. Mixing them in equal proportions gives a white surface. By embedding the CSRs in an index matching transparent medium, nonselective specular reflections and scattering are avoided. The approach can be used to create arbitrary colors, including nonspectral ones, without any absorption or nonselective scattering, opening doors to decorating surfaces as desired while minimizing light loss.
Semimetal–Monolayer Transition Metal Dichalcogenides Photodetectors for Wafer‐Scale Broadband Photonics
Authors: Sinn Hon-Loen , Kumar Aravindh , Pop Eric , Newaz Akm
Published: March 2023

Atomically thin 2D transition metal dichalcogenides (TMDs), such as MoS2, are promising candidates for nanoscale photonics because of strong light–matter interactions. However, Fermi‐level pinning due to metal‐induced gap states (MIGS) at the metal–monolayer (1L)‐MoS2interface limits the application of optoelectronic devices based on conventional metals due to high contact resistance. On the other hand, a semimetal–TMD–semimetal device can overcome this limitation, where the MIGS are sufficiently suppressed allowing ohmic contacts. Herein, the optoelectronic performance of a bismuth–1L‐MoS2–bismuth device with ohmic electrical contacts and extraordinary optoelectronic properties is demonstrated. To address the wafer‐scale production, full coverage 1L‐MoS2grown by chemical vapor deposition. High photoresponsivity of 300 A W−1at wavelength 400 nm measured at 77 K, which translates into an external quantum efficiency (EQE) ≈1000 or 105%, is measured. The 90% rise time of the devices at 77 K is 0.1 ms, suggesting they can operate at the speed of ≈10 kHz. High‐performance broadband photodetector with spectral coverage ranging from 380 to 1000 nm is demonstrated. The combination of large‐array device fabrication, high sensitivity, and high‐speed response offers great potential for applications in photonics, including integrated optoelectronic circuits.
Bendamustine plus rituximab for the treatment of Waldenström Macroglobulinemia: Patient outcomes and impact of bendamustine dosing
Authors: Arulogun Suzanne O. , Brian Duncan , Goradia Harshita , Cooney Aaron , Menne Tobias , Koo RayMun , O'Neill Aideen T. , Vos Josephine M. I. , Pratt Guy , Turner Deborah , Marshall Kirsty , Manos Kate , Anderson Claire , Gavriatopoulou Maria , Kyriakou Charalampia , Kersten Marie J. , Minnema Monique C. , Koutoumanou Eirini , El‐Sharkawi Dima , Linton Kim , Talaulikar Dipti , McCarthy Helen , Bishton Mark , Follows George , Wechalekar Ashutosh , D'Sa Shirley P.
Published: March 2023

Bendamustine and rituximab (BR) therapy is commonly used in the treatment of Waldenström Macroglobulinemia (WM). The impact dose of Bendamustine dose on response and survival outcomes is not well‐established, and the impact of its use in different treatment settings is not clear. We aimed to report response rates and survival outcomes following BR, and clarify the impact of depth of response and bendamustine dose on survival. A total of 250 WM patients treated with BR in the frontline or relapsed settings were included in this multicenter, retrospective cohort analysis. Rates of partial response (PR) or better differed significantly between the frontline and relapsed cohorts (91.4% vs 73.9%, respectively; p < 0.001). Depth of response impacted survival outcomes: two‐year predicted PFS rates after achieving CR/VGPR vs PR were 96% versus 82%, respectively (p = 0.002). Total bendamustine dose was predictive of PFS: in the frontline setting, PFS was superior in the group receiving ≥1000 mg/m2 compared with those receiving 800–999 mg/m2 (p = 0.04). In the relapsed cohort, those who received doses of <600 mg/m2 had poorer PFS outcomes compared with those who received ≥600 mg/m2 (p = 0.02). Attaining CR/VGPR following BR results in superior survival, and total bendamustine dose significantly impacts response and survival outcomes, in both frontline and relapsed settings.
Neonatal lupus is a novel cause of positive newborn screening for X‐linked adrenoleukodystrophy
Authors: Niehaus Annie D. , Mendelsohn Bryce A. , Zimmerman Bree , Lee Chung U. , Manning Melanie A. , Cusmano‐Ozog Kristina P. , Tise Christina G.
Published: March 2023

We report three unrelated individuals, each exposed to maternal autoantibodies during gestation and found to have elevated very long‐chain fatty acids (VLCFAs) in the newborn period after screening positive by California newborn screening (NBS) for X‐linked adrenoleukodystrophy (ALD). Two probands presented with clinical and laboratory features of neonatal lupus erythematosus (NLE); the third had features suggestive of NLE and a known maternal history of Sjogren's syndrome and rheumatoid arthritis. In all three individuals, subsequent biochemical and molecular evaluation for primary and secondary peroxisomal disorders was nondiagnostic with normalization of VLCFAs by 15 months of age. These cases add to the expanding differential diagnosis to consider in newborns who screen positive for ALD via elevated C26:0‐lysophosphatidylcholine. Though the pathophysiology of how transplacental maternal anti‐Ro antibodies damage fetal tissue is not well‐understood, we postulate that the VLCFA elevations reflect a systemic inflammatory response and secondary peroxisomal dysfunction that improves once maternal autoantibodies wane after birth. Additional evaluation of this phenomenon is warranted to better understand the intricate biochemical, clinical, and possible therapeutic overlap between autoimmunity, inflammation, peroxisomal dysfunction, and human disease.
Prevalence of cardiovascular manifestations in patients with hypermobile Ehlers‐Danlos syndrome at the University of Miami
Authors: Pietri‐Toro Jariselle M. , Gardner Olivia K. , Leuchter Jessica D. , DiBartolomeo Gabrielle , Hunter Juanita A. , Forghani Irman
Published: March 2023

Cardiovascular system involvements have been frequently reported in hypermobile Ehlers‐Danlos Syndrome (hEDS). Mitral valve prolapse (MVP) and aortic root dilatation are included in the 2017 international classification criteria for hEDS. Different studies have found conflicting results regarding the significance of cardiac involvement in hEDS patients. We conducted a retrospective review of cardiac involvement in patients diagnosed with hEDS based on the 2017 International diagnostic criteria to provide further evidence toward more defined and reliable diagnostic criteria and recommended cardiac surveillance. A total of 75 hEDS patients with at least one diagnostic cardiac evaluation were included in the study. The most common reported cardiovascular complaints were lightheadedness (80.6%), followed by palpitations (77.6%), fainting (44.8%), and chest pain (32.8%). Of the 62 echocardiogram reports, 57 (91.9%) showed trace/trivial to mild valvular insufficiency, and 13 (21%) had additional abnormalities such as grade I diastolic dysfunction, mild aortic sclerosis, and trivial or small pericardial effusion. Of the 60 electrocardiograms (ECG) reports, 39 (65%) were normal, and 21 (35%) reported minor abnormalities or normal variants. Even though many hEDS patients in our cohort experienced cardiac symptoms, the presence of a significant cardiac abnormality was very low.
Strategies towards the Synthesis of 2‐Ketoaryl Azole Derivatives using C‐H Functionalization Approach and 1,2‐Bis‐Nucleophile Precursors
Authors: Aljaar Nayyef , Ibrahim Mohammad M. , Younes Eyad A. , Al‐Noaimi Mousa , Abu‐Safieh Kayed A. , Ali Basem F. , Kant Kamal , Al‐Zaqri Nabil , Sengupta Ragini , Malakar Chandi C.
Published: March 2023

A spectrum of compounds attached to 2‐keto aryl azole moieties are found as pivotal building blocks in medicinal chemistry and drug discovery. This is why, the collection of novel methods have been described for the synthesis of these compounds, which are of great significance among organic chemists interested towards the development of new synthetic methods in the fields of natural products, bioactive molecules and materials sciences. This review presents the important breakthrough achieved during last decade towards improvement of approaches for the synthesis of these molecules.
An n‐Type Polythiophene Derivative with Excellent Thermoelectric Performance
Authors: Deng Sihui , Dong Changshuai , Liu Jian , Meng Bin , Hu Junli , Min Yang , Tian Hongkun , Liu Jun , Wang Lixiang
Published: March 2023

Typical n‐type conjugated polymers are based on fused‐ring electron‐accepting building blocks. Herein, we report a non‐fused‐ring strategy to design n‐type conjugated polymers, i.e. introducing electron‐withdrawing imide or cyano groups to each thiophene unit of a non‐fused‐ring polythiophene backbone. The resulting polymer, n‐PT1, shows low LUMO/HOMO energy levels of −3.91 eV/−6.22 eV, high electron mobility of 0.39 cm2 V−1 s−1 and high crystallinity in thin film. After n‐doping, n‐PT1 exhibits excellent thermoelectric performance with an electrical conductivity of 61.2 S cm−1 and a power factor (PF) of 141.7 μW m−1 K−2. This PF is the highest value reported so far for n‐type conjugated polymers and this is the first time for polythiophene derivatives to be used in n‐type organic thermoelectrics. The excellent thermoelectric performance of n‐PT1 is due to its superior tolerance to doping. This work indicates that polythiophene derivatives without fused rings are low‐cost and high‐performance n‐type conjugated polymers.
Outer‐Shell Self‐Supported Nickel Catalysts for the Synthesis of Polyolefin Composites
Authors: Li Jie , Peng Dan , Tan Chen , Chen Changle
Published: March 2023

In situ heterogeneous olefin polymerization has attracted much attention for the synthesis of polyolefin composites. However, the complicated syntheses of specially designed catalysts or the detrimental effects of interactions between catalyst and solid supports pose great challenges. In this contribution, an outer‐shell self‐supporting strategy was designed to heterogenize nickel catalysts on different fillers via precipitation homopolymerization of ionic cluster type polar monomer. These catalysts demonstrated high activity, good product morphology control, and stable performances in ethylene polymerization and copolymerization. Moreover, various polyolefin composites with great mechanical and customized properties can be efficiently synthesized.
Allosterically Regulated Guest Binding Determines Framework Symmetry for an FeII4L4 Cage
Authors: Xue Weichao , Wu Kai , Ouyang Nianfeng , Brotin Thierry , Nitschke Jonathan R.
Published: March 2023

Self‐assembly of a flexible tritopic aniline and 3‐substituted 2‐formylpyridine subcomponents around iron(II) templates gave rise to a low‐spin FeII4L4 capsule, whereas a high‐spin FeII3L2 sandwich species formed when a sterically hindered 6‐methyl‐2‐formylpyridine was used. The FeII4L4 cage adopted a new structure type with S4 symmetry, having two mer‐Δ and two mer‐Ʌ metal vertices, as confirmed by NMR and X‐ray crystallographic analysis. The flexibility of the face‐capping ligand endows the resulting FeII4L4 framework with conformational plasticity, enabling it to adapt structurally from S4 to T or C3 symmetry upon guest binding. The cage also displayed negative allosteric cooperativity in simultaneously binding different guests within its cavity and at the apertures between its faces.
Linear and Bent Cp*2Si: Reversible Phase Transition of a Key Molecule
Authors: Ruth Paul Niklas , Sarcevic Julijan , Herbst‐Irmer Regine , Sindlinger Christian P. , Stalke Dietmar
Published: March 2023

The solid‐state structure of decamethylsilicocene Cp*2Si with a bent and a linear molecule in the same unit cell was so far considered an exception in relation to the structures of its all‐bent heavier analogues Cp*2E with E=Ge, Sn, Pb. Here, we present the solution to this conundrum by reporting a low‐temperature phase, where all three symmetrically independent molecules are present in a bent formation. This reversible enantiotropic phase transition occurs in the temperature range between 80 K and 130 K and provides a rationale for the unexpected linear molecule based in entropy beyond hand‐waving explanations such as electronic reasons or packing effects.
Single‐ion conducting polymer as lithium salt additive in polymerized ionic liquid block copolymer electrolyte
Authors: Goujon Nicolas , Mendes Tiago , Barlow Kristine J. , Kerr Robert , O'Dell Luke A. , Chiefari John , Howlett Patrick C. , Forsyth Maria
Published: March 2023

Herein, we describe the use of single‐ion conducting block copolymer (SIC) as an additional lithium salt additive to a ternary solid polymer electrolyte (SPE), consisting of a poly(styrene‐b‐1‐((2‐acryloyloxy)ethyl)‐3‐butylimidazolium bis(trifluoromethanesulfo‐nyl)imide) (S‐ImTFSI64‐16) block copolymer, a N‐propyl‐N‐methylpyrrolidinium bis(fluorosulfonyl)imide (C3mpyrFSI) ionic liquid (IL) and a lithium bis(fluorosulfonyl) imide (LiFSI) salt. For this purpose, the S‐ImTFSI64‐16 was substituted by a SIC, based on poly(styrene‐b‐((4‐styrenesulfonyl)(trifluoromethanesulfonyl)imide lithium salt)) (S‐STFSILi64‐16), at various molar ratios. The impact of the SIC concentration on the phase behavior and transport properties of the SPEs was investigated by means of differential scanning calorimetry, electrochemical impedance spectroscopy, and diffusion NMR. In addition, the electrochemical performance of the SPEs was assessed in lithium symmetrical cell at 50 and 80°C. Finally, the cycling performance of a selected SPE was also assessed at 80°C in a Li│NMC111 cell with capacity loading of 1.3 mAh.cm−2 at a C‐rate of 0.1 C. The Li│NMC111 full cell was able to deliver a stable capacity of 0.94 mAh.cm−2 after 20 cycles, corresponding to a capacity of 117 mAh.g−1. These results demonstrates that PIL block copolymer—IL—salt composites represent a promising choice of electrolyte for the next generation of solid‐state high energy density lithium metal batteries.
Functionalized carbon nanotubes/polyimide nanocomposites with high energy density for high‐temperature dielectric materials
Authors: Zhou Liang , Li Chenjian , Wu Wenwen , Xiong Chuanxi , Gao Zhaodongfang
Published: March 2023

Polymer‐based dielectric capacitors have attracted much attention because of their good flexibility, lightness, and high‐power density. However, the current polymer dielectric capacitors usually have too low energy density and cannot be used in high temperature environments, which limits the further development. Therefore, it has become increasingly important to develop high‐temperature dielectric materials with high energy density and low dielectric loss. In this study, long‐chain functionalized carbon nanotubes (CNTF) were introduced in Polyimide (PI) to obtained CNTF/PI composite film. CNTF have good compatibility with polymer and can solve the dispersion problem. The CNTF/PI composite film exhibits good dielectric property and an ultralow dielectric loss of 0.015. Especially, the discharged energy density of 3.77 J/cm3 of CNTF/PI composite film is the highest discharged energy density of reported polyimide‐based dielectric films at 300 MV/m. Therefore, these polyimide‐based dielectric materials are promising in the high temperature field of novel high‐performance film dielectric capacitor.
Understanding the Electrochemical and Interfacial Behavior of Sulfolane based Electrolyte in LiNi0.5Mn1.5O4‐Graphite Full‐Cells
Authors: Salian Girish D. , Mathew Alma , Gond Ritambhara , van Ekeren Wessel , Højberg Jonathan , Fink Elkjær Christian , Lacey Matthew J. , Heiskanen Satu Kristiina , Brandell Daniel , Younesi Reza
Published: March 2023

An ethylene carbonate‐free electrolyte composed of 1 M lithium bis(fluorosulfonyl) imide (LiFSI) in sulfolane (SL) is studied here for LiNi0.5Mn1.5O4‐graphite full‐cells. An important focus on the evaluation of the anodic stability of the SL electrolyte and the passivation layers formed on LiNi0.5Mn1.5O4 (LNMO) and graphite is being analysed along with intermittent current interruption (ICI) technique to observe the resistance while cycling. The results show that the sulfolane electrolyte shows more degradation at higher potentials unlike previous reports which suggested higher oxidative stability. However, the passivation layers formed due to this electrolyte degradation prevents further degradation. The resistance measurements show that major resistance arises from the cathode. The pressure evolution during the formation cycles suggests that there is lower gas evolution with sulfolane electrolyte than in the conventional electrolyte. The study opens a new outlook on the sulfolane based electrolyte especially on its oxidative/anodic stability.
Expanding the CRISPR toolbox for Chinese hamster ovary cells with comprehensive tools for Mad7 genome editing
Authors: Rojek Johan B. , Basavaraju Yogesh , Nallapareddy Saranya , Bulté Dubhe B. , Baumgartner Roland , Schoffelen Sanne , Grav Lise M. , Goletz Steffen , Pedersen Lasse E.
Published: March 2023

The production of high‐value biopharmaceuticals is dominated by mammalian production cells, particularly Chinese hamster ovary (CHO) cells, which have been widely used and preferred in manufacturing processes. The discovery of CRISPR‐Cas9 significantly accelerated cell line engineering advances, allowing for production yield and quality improvements. Since then, several other CRISPR systems have become appealing genome editing tools, such as the Cas12a nucleases, which provide broad editing capabilities while utilizing short guide RNAs (gRNAs) that reduce the complexity of the editing systems. One of these is the Mad7 nuclease, which has been shown to efficiently convey targeted gene disruption and insertions in several different organisms. In this study, we demonstrate that Mad7 can generate indels for gene knockout of host cell proteins in CHO cells. We found that the efficiency of Mad7 depends on the addition of protein nuclear localization signals and the gRNAs employed for genome targeting. Moreover, we provide computational tools to design Mad7 gRNAs against any genome of choice and for automated indel detection analysis from next‐generation sequencing data. In summary, this paper establishes the application of Mad7 in CHO cells, thereby improving the CRISPR toolbox versatility for research and cell line engineering.
Intramuscular innervation of the tensor fasciae latae: Application to total hip arthroplasty
Authors: Choi Seonui , Yang Hun‐Mu , Cho Tae‐Hyeon , Yeo In‐Seung , Won Sung‐Yoon
Published: March 2023

The aims of this study were to clarify the extra‐ and intramuscular branching patterns of the tensor fasciae latae (TFL) with reference to surface landmarks on the thigh and to thus suggest a safe approach for total hip arthroplasty. Sixteen fixed and four fresh cadavers were dissected and subjected to the modified Sihler's staining method to reveal the extra‐ and intramuscular innervation patterns, and the findings were matched with surface landmarks. The landmarks were measured from the anterior superior iliac spine (ASIS) to the patella and divided into 20 parts along the total length. The average vertical length of the TFL was 15.92 ± 1.61 cm, which was 38.79 ± 2.73% when converted to a percentage. The entry point of the superior gluteal nerve (SGN) was an average of 6.87 ± 1.26 cm (16.71 ± 2.55%) from the ASIS. In all cases, the SGN entered parts 3–5 (10.1%–25%). As the intramuscular nerve branches traveled distally, they had a tendency to innervate more deeply and inferiorly. In all cases, the main SGN branches were intramuscularly distributed in parts 4 and 5 (15.1%–25%). Most tiny SGN branches were found inferiorly in parts 6 and 7 (25.1%–35%). In three of 10 cases, very tiny SGN branches were observed in part 8 (35.1%–38.79%). We did not observe SGN branches in parts 1–3 (0%–15%). When information on the extra‐ and intramuscular nerve distributions was combined, we found that the nerves were concentrated in parts 3–5 (10.1%–25%). We propose that damage to the SGN can be prevented if parts 3–5 (10.1%–25%) are avoided during surgical treatment, particularly during the approach and incision.
A controlling nutritional status score is an independent predictor for patients with newly diagnosed nasal‐type extranodal NK/T‐cell lymphoma based on asparaginase‐containing regimens
Authors: Wu Wanchun , Ren Kexin , Chen Xi , Li Na , Zhou Huijie , Jiang Ming , Yu Youhui , Zou Liqun
Published: March 2023

Background

The controlling nutritional status (CONUT) score is a nutritional index that combines serum albumin, total cholesterol, and lymphocyte counts. The potential value of CONUT score for predicting clinical outcomes in patients with nasal‐type extranodal NK/T‐cell lymphoma (ENKTL) has not been explored.

Methods

This study included 374 ENKTL patients treated with asparaginase‐containing regimens from September 2012 to September 2017. Clinical characteristics, treatment efficacy, prognostic factors, and the predictive value of CONUT score were analyzed.

Results

The complete response (CR) and overall response rate (ORR) were 54.8% and 74.6%, respectively. Patients with CONUT scores <2 had higher CR and ORR compared to patients with scores ≥2 (69.1% vs. 48.9% for CR, p = 0.001; 90.0% vs. 74.6% for ORR, p < 0.001). The 5‐year overall survival (OS) and progression‐free survival (PFS) rates were 61.9% and 57.3%, respectively. Patients with CONUT scores <2 had better survival outcomes than those with scores ≥2 (5‐year OS, 76.1% vs. 56.0%, p < 0.001; 5‐year PFS, 74.4% vs. 50.1%, p < 0.001). CONUT score ≥2 was identified as an independent poor prognostic factor for both OS and PFS. A CONUT score ≥2 was also associated with poorer survival outcomes in low‐risk ENKTL patients.

Conclusion

A CONUT score ≥2 is a prognostic marker for poor survival in patients with ENKTL and could be used to stratify risk in low‐risk patients.
New Polyketide and Sesquiterpenoid Derivatives from the Magellan Seamount‐Derived Fungus Penicillium rubens AS‐130
Authors: Ying Zhen , Li Xiao‐Ming , Yang Sui‐Qun , Wang Bin‐Gui , Li Hong‐Lei , Meng Ling‐Hong
Published: March 2023

Rubenpolyketone A (1), a polyketide featuring a new carbon skeleton having cyclohexenone condensed with a methyl octenone chain and a new linear sesquiterpenoid, chermesiterpenoid D (2), together with seven known secondary metabolites (3–9) were isolated and identified from the Magellan Seamount‐derived fungus Penicillium rubens AS‐130. Their structures were determined based on detailed analysis of NMR and mass spectroscopic data and the absolute configurations of these two new compounds were elucidated by the combination of quantum mechanical (QM)‐NMR and time‐dependent density functional (TDDFT) ECD calculation approaches. Chermesiterpenoids B (3) and C (4) showed potent inhibitory activities against the aquatic pathogen Vibrio anguillarum with MIC values of 0.5 and 1 μg/mL, respectively, while chermesin F (6) exhibited activity against Escherichia coli with MIC value of 1 μg/mL.