bluuebunny/crossref_metadata_2025 huggingface dataset:
Epidemiological analysis of strokes in Grande Vitória, Espírito Santo
Authors: Barreto Catharina Mello , Arita Amanda Ferraz , Bravin Ana Carolina Coutinho Engelhardt , Matta Julia Surrage da , Fonseca Maria de Fatima Araujo da , Mousinho Pietra Sardinha Silvestre
Published: December 2021

Introduction: Stroke is a neurological syndrome resulting from a vascular injury that represents one of the main causes of morbidity and mortality in the world. Thus, cerebrovascular diseases are increasing in Brazilian statistics, especially the ischemic stroke, responsible for the highest incidence in cases, therefore characterizing a major public health issue. Methods: In this descriptive and ecological study we used data provided by DATASUS concerning hospitalizations and deaths due to stroke, not specified as hemorrhagic or ischemic, occurred between January 2008 and December 2020 in the region of Grande Vitória, Espírito Santo (GV – ES). Results: Overall, there were 10,199 hospitalizations due to stroke in the GV-ES. The prevalence was 57.2% in brown-skinned people, 26.2% between ages from 60 to 69 years old (26.2%) and 52% in Vitória. Among 2008 until 2014 there was an increase of 788.9% in stroke hospitalizations however between 2015 and 2020 there was a 30.5% reduction. In total there were 1,309 deaths, 64% were brown-skinned people, 29.2% above 80 years old and 51.3% in Vitoria. From 2008 to 2019, a 144.5% increase in the mortality rate was observed. In the analyzes there was no difference regarding the gender. Conclusion: Data analysis inferred that old age and brown skin are risk factors for stroke in GV-ES, thereby requiring greater attention for screening and preventing this disease in those groups. Moreover, there was an increase in the mortality rate, even with reduction in the number of cases, reinforcing the need for effective and resolute care in the region.
Cerebrovascular accident treatment procedures: an analysis of the national scenario
Authors: Leite Izabel Feitosa da Mata , Hernandes Júnior Paulo Roberto , Moreira Neto Adelina Mouta , Moraes Guilherme de Aguiar , Albernaz Lucas Cardoso Siqueira , Medeiros Matheus de Campos
Published: December 2021

Introduction: Cerebrovascular accident (CVA) is a medical emergency and it is the second cause of mortality worldwide. Due to high prevalence, systematic analyzes should be performed in order to help improve mortality curves. Objectives: Analyze current scenario of CVA treatment procedures performed in Brazil during 12 years and correlate with results. Methods: Literature review associated to an observational, descriptive and horizontal collection of hemorrhagic or ischemic CVA treatment data, available at DATASUS - SUS Hospital Information System (SIH / SUS) - from January 2008 to December 2019 - was carried out evaluating number of hospitalizations, public spending, complexity, mortality rate, permanence, character of care. Results: 2,173,466 hospitalizations were reported, total expenditure of R$ 2,659,605,859.72. The highest number of hospitalizations and the highest amount spent occurred in 2019. Considering total procedures, 67,141 were performed as elective and 2,105,861 were urgent basis. 700,063 were performed in public services and 670,230 in the private sector, both of medium complexity. Total mortality rate was 16.62% - decreasing over the 12 years, with 2019 having the lowest rate, 15.72%. Mortality rate for elective procedures was 13.14% compared to 16.73% for urgent, whereas in the public sector it was 18.79% compared to 14.91% for the private. Conclusion: Despite decreasing mortality over years, there is discrepancy between private and public services. In this scenario, high mortality rate was found in both services although highlighted at the public sector. Better investments are needed, aiming to reduce global mortality.
Transcranial Direct Current Stimulation in the Management of Refractory Symptoms of Parkinson’s Disease: A Systematic Review
Authors: Lellis Caio de Almeida , Herbas Marco Alejandro Menacho , Dantas Glaucia Borges , Galvão Leonardo Rizier
Published: December 2021

Introduction: Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique increasingly used in neurology. Objectives: To evaluate the safety and efficacy of tDCS in refractory symptoms of Parkinson’s disease (PD). Design and setting: A systematic review of the literature conducted at the Pontifical Catholic University of Goiás. Methods: A systematic review of the literature was conducted in the MedLine and Lilacs databases, with the following search strategy: “(Parkinson Disease) AND (Transcranial Direct Current Stimulation OR TDCS)”. Randomized clinical trials (10 years) were included. Results: One of the studies concluded that simultaneous tDCS of the primary motor cortex (M1) and dorsolateral prefrontal cortex (DLPC) Also, two other articles evaluated the motor response after stimulation of the left DLPC for 20 minutes, with the first realizing improved fine motor performance and attenuation of common oscillatory cortical activity in PD patients, while the second finding an improvement in balance and functional mobility when compared to placebo. Regarding cognitive and mood changes, one of the studies pointed out that a single session of tDCS on the left DLPC is insufficient to improve working memory and inhibition control. Conclusion: tDCS was shown to be a safe and effective therapeutic option in reducing gait freezing and mood disorders, as well as improving fine motor performance and cognition. It is emphasized that further studies on the subject with a larger sample are needed.
Thoracolumbar progressive myelopathy due to extra-dural arteriovenous fistula
Authors: Trivellato Stella de Angelis , Salgado Joao Lucas Gomes , Gramasco Hendrick Henrique Fernandes , Anastacio Guilherme Drumond Jardini , Santos Daniel Fabiano Barbosa Dos , Lopes Laura Cardia Gomes , Moreira Júlio Cesar dos Santos
Published: December 2021

Context: Arteriovenous dural fistulas are the most common spinal vascular malformations and constitute a reversible cause of progressive myelopathy. This disease affects elderly men and are classically found at the thoracolumbar region. Case report: A 69year-old man was admitted to the Neurology outpatient clinic with weakness in his left inferior limb for the past 10 years; 2 years before the evaluation, the weakness progressed also to the right inferior limb, causing inability to walk, and 1 year after the patient noticed urinary incontinence and sexual dysfunction. Physical evaluation showed grade-II paraparesis with spastic hypertonia; hypoesthesia below T-10 dermatome; hyperreflexia with clonus and Babinski sign in inferior limbs. Investigation with MRI showed abnormal hypersignal within spinal cord from T6-T7 to the medullary cone; CSF sample had hyper protein count without pleocytosis. Before the hypothesis of non- compressive, non-inflammatory and non-infectious myelopathy, we performed a spinal angiography – which diagnosed a dural arteriovenous fistula at the level of T8 connecting spinal with extradural vessels. The patient was then treated by endovascular therapy with fistula embolization. Conclusion: Although being the most common vascular spinal malformation, arteriovenous dural fistulas are rare and underdiagnosed because of their nonspecific symptoms. The aim of treatment is the shunt occlusion but its prognosis depends on the duration and intensity of symptoms before treatment. This report’s aim is to exemplify a typical case of this condition.
Traumatic brain injury in Brazil: a comparative analysis between deaths and hospitalizations from 2015 to 2019
Authors: Almeida Mateus Ribeiro de , Borges Laila Santos , Moraes Giovana Aquino de , Ribeiro Felipe Fróes Batista , Filardi Giovanna Souza , Aragão Maria Clara Leite , Brito Katharina Andrade de
Published: December 2021

Background: Traumatic brain injury (TBI) is a type of head injury with great relevance to the health service, affecting an average of 100,000 Brazilians/year. It’s one of the main causes of trauma morbidity and mortality, becoming an important public health problem. Objectives: Analyze the evolution of deaths, mortality rate (MR) and hospitalizations by TBI in Brazil during 2015-2019. Methods: An epidemiological, retrospective, descriptive study was carried out, using data from the Information Technology Department of the Unified Health System (DATASUS), during 2015-2019. Results: 514,666 hospitalizations and 48,554 deaths from TBI were reported during 2015-2019 in Brazil. In hospitalizations, the year with the highest records was 2015 (20.8%, n=106,980), while the lowest was 2019 (18.3%, n=94,055). There was a progressive reduction in hospitalizations in the period, with a decrease of 12.1% of hospitalizations in the interval. The number of deaths varied from year to year, with peak prevalence in 2016 (21.1%, n=10,264), and a progressive reduction after that year about 15.3% until 2019 (17.9%, n=8,691). Most deaths occurred in the Southeast (45.6%, n=22,144), while the Midwest (6.5%, n=3,169) registered lower rates. However, the highest MR recorded was in the North (MR=6.9), exceeding the national average (MR=6.3) in the period, while the lowest belonged to the South (MR=6.1). Conclusion: Despite the variations between 2015-2019, there was a decrease in deaths and hospitalizations in the period. Deaths were concentrated in Southeast, however, the largest MR was in the North.
Pure neural leprosy or amyloid neuropathy? systematic review and clinical case report
Authors: Souza Carlos Dornels Freire de , Santos Lucas Gomes , Paiva João Paulo Silva de , Leal Thiago Cavalcanti , Santana Gibson Barros de Almeida , Matos Thais Silva , Rocha Carlos Alberto de Oliveira , Silva Leonardo Feitosa da , Albuquerque Antônio Leopoldo do Nascimento Gama , Moura José Carlos de , Silva Tarcísio Fulgêncio Alves da , Santos Lucas Oliveira dos , Barbosa Thamyres Rats de Souza , Batista Jemima Araujo da Silva , Fernandes Tânia Rita Moreno de Oliveira
Published: December 2021

Objective: To review the literature, including a clinical case discussion with suspicion of pure neural leprosy and final diagnosis of amyloid neuropathy. Methods: The study was conducted on May 28, 2020. A systematic review of the literature was conducted, with searches in PubMed, Medline, Lilacs and BVS MS using the descriptors: neuritic leprosy, pure neural leprosy, primary neural leprosy, pure neuritic leprosy, amyloid polyneuropathy, amyloid neuropathies, amyloid polyneuropathy. Clinical trials, cohorts, cross-sectional, clinical cases and case studies, published in Portuguese, English or Spanish between 2010 and 2020 were included. Then, a case report with an initial suspicion of pure neural leprosy was presented. Laboratory tests, electroneuromyography, ultrasound and biopsy of the sural nerve were requested. Results: 23 scientific texts were included. No publications with the two themes together were found. Diagnosis of pure neural leprosy and the possibility of using auxiliary resources were the most prominent themes in the studies. In the clinical case, the patient’s electroneuromyography showed sensitive and motor polyneuropathy of lower limbs, symmetrical, of moderate intensity, of the mixed type (axono- demyelinating), sensitive and axonal. Ultrasonography of the sural nerve revealed changes in the contour of the deep fibular nerves and biopsy of the sural nerve demonstrated the accumulation of amorphous eosinophilic material in the nerve path and Congo red staining showed birefringence of the deposit in applegreen under polarized light. The final diagnosis was amyloidotic neuropathy. Conclusion: Clinical diagnosis was amyloidotic neuropathy. Diagnosis of pure neural leprosy in endemic areas of Brazil is a challenge for the health system.
Medical Complications at a Stroke Unit (SU) of a Tertiary Center in Brazil
Authors: Moraes Junior Anisio Adalio de Azevedo , Conforto Adriana Bastos , Tinone Gisela , Fonseca Barbara Silva da
Published: December 2021

Background: Stroke is the second leading cause of death in Brazil. All stroke patients should receive care at a SU in accordance with the guidelines of the American Heart Association (AHA)/American Stroke Association (ASA) - Class of recommendation I. Our institution is provided with a SU since 2019. Objective: To describe the rate of medical complications at our SU. Design and setting: This is a longitudinal descriptive study settled at the ICHCFMUSP. Methods: The incidence of complications during hospitalization at the UAVC was prospectively recorded. The rates of pneumonia, pressure ulcer, urinary tract infection (UTI), and venous thromboembolism (VTE) were analyzed. The period analyzed was from january/2019 to december/2020. Results: 379 patients were admitted at our SU. 50 patients (13.1%) presented at least one complication. 35 patients had only 1 complication, 13 patients had 2 complications, 1 patient had 3 complications and 1 patient had 4 complications. The most frequent complication was UTIs (7.9%), followed by pneumonia (5%), pressure ulcer (2.3%) and VTE (2.3%). 4 patients died during hospitalization at the SU. Conclusion: The rate of complications in our SU is low according to the literature.
Mechanisms of Neuroplasticity After Pediatric Stroke: A Review
Authors: Novais Aurea Maria Lago , Branco Renan Carvalho Castello
Published: December 2021

Introduction: Stroke in childhood constitute a rare event and its incidence is increasing due to advances in neuroimaging.This study clarifies anatomic and molecular mechanisms involved in neuroplasticity after children stroke, demonstrating its specificities in motor,somatosensory and language habilities. Methods: We used database, from 2000 to march 2021,of SpringerLink,NEJM,PubMed, AHA (Stroke),Scielo,VHL and JAMA.The research was based in the keywords “neuplasticity”, “stroke” and “children”; 57 were selected including original articles, case reports and reviews, considering abstract according to the objective of the present study and methodologies that satisfy criterias of cientific valuation, considering p <0,005 as statistical significance. Results: Reduction of ipsilesional cortex and better prognosis between the ages of 1 and 6 years were observed. About motor function, it was found persistence of some perilesionais circuits, contralateral reorganization with increasing activation of suplementary motor area, unbalance of intrahemisferics inhibitory mechanisms, increase of excitability and changes in the concentration of N-acetyl-aspartate, choline, myo-inositol and creatine. Somatosensory skills presented limited plasticity. Contralesional alterations in arched fasciculi and temporoparietal area, circuit remodelation and compromissing of complex cognitive functions were observed for language habilites. Conclusion: Better outcomes in the ages of 1 to 6 years demonstrate the duality between early vulnerability and early plasticity. The plasticity of motor system demonstrates therapeutic targets and potencial rehabilitation markers; otherwise, the limited potencial of somatossensorial habilities indicates its premature determination. Language skills presented limited prognosis.
Epidemiological profile of TBI in children under 10 years old before and after the implementation of the child seat law in Brazil
Authors: Lima Rebeca Menezes de Oliveira , Sanches Brenda Luiza de Sousa , Soare Guilherme Ribeiro , Bahia Tauá Vieira
Published: December 2021

Background: The Car Seat Law (2008) aims to minimize the impacts of traffic accidents on children under 10 years old, including the Traumatic Brain Injury (TBI). Objectives: To compare the epidemiological profile of TBI in children under 10 years old before and after the implementation of the Child Seat Law in Brazil. Design and setting: Ecological study in Brazil. Methods: Data was collected from the Ministry of Health, through DATASUS. The decade prior (1998- 2007) and subsequent (2009-2018) to the implementation of the Law were analyzed. The data collected included children of 10 years or less, average length of stay, hospitalizations, deaths, and mortality. Results: The average mortality between 1998-2007 was 2.31, while between 2009-2018 was 1.59, reducing 30.8%. There was also a reduction of 11% in the average stay averages, which went from 3.6 to 3.2 days. There was a 30.7% decrease in the lethality rate, from 2.3 to 1.6. The median of hospitalizations before the Law was 14,230, while afterwards it was 12,851. Conclusion: There was a significant decrease in the average mortality rate, lethality rate and average stay averages since the Law. This may suggest the Law’s effectiveness in protecting children under 10 years of age.
Medium cerebral artery thrombosis – radiological fing: hyperdense MCA sign – case report
Authors: Silva Bruno Custódio , Nascimento Vivianne Amanda do , Vieira Maria Isabelle Nakano , Spiller Guilherme Rocha , Lago Celso David
Published: December 2021

Introduction: Vascular diseases are the leading cause of death in the world. Although major advances in neuroimaging and stroke treatment have contributed to a decrease in mortality, strokes occupy second place in the list. Case report: A 75-year-old man is admitted to emergency with an altered neurological examination: right hemiplegia, Broca’s aphasia and dysphagia. Conscience was preserved. Computed tomography (CT) was performed, which showed the radiological finding of hyperdense MCA sign, confirming the diagnosis of ischemic stroke with involvement of the left middle cerebral artery branch. The treatment, in this case, was outside the criteria for thrombolytics. Discussion: Irrigation of the brain is done by Willis polygon. One of the essential branches is the medium cerebral artery (MCA), the most important termination of the internal carotid arteries, responsible for blood supply of the dorsolateral hemifacial of both cerebral hemispheres, irrigating the frontal, parietal and temporal lobes. The imaging exam in suspected cases of stroke focuses on confirming its diagnosis and etiology, location of the lesion, extent of ischemic evolution, therapeutic treatment and prognosis. CT is the main modality of neuroimaging for stroke and an important radiological finding is the hyperdense artery sign, which is more common in MCA and demonstrates an evolving or impending infarction and is secondary to a plunger housed in this vessel. Therefore, it is an important early tomographic sign of ischemic stroke found on non-contrast blood CT. Conclusion: Ischemic stroke is the most common etiology among strokes. The diagnosis must be based mainly on anamnesis and image exam, such as a CT scan. The CT performed helps to guide treatment, prognosis and clinical evolution. Finally, the recognition of the hyperdense MCA sign, found in the first 6 hours, is also extremely helpful for stroke classification.
Classifying pain in dystonia: a way to improve pain outcome measure in dystonia
Authors: Listik Clarice , Listik Eduardo , Lapa Jorge Dornellys , Santos Graziele Costa , Vale Fabricio Vianna do , Cury Rubens Gisbert , Teixeira Manoel Jacobsen , Limongi João Carlos Papaterra , Ferraz Henrique Ballalai , Barbosa Egberto Reis , Andrade Daniel Ciampi de
Published: December 2021

Background: Pain is a frequent and incapacitating non-motor symptom in dystonia. Evidence indicates that pain in dystonia is not only of muscular origin, but pain’s descending modulatory systems are impaired in dystonia. There is much to be learned about this topic. Still, we do not have a simple and straightforward way to classify, evaluate pain, and assess its improvement after pharmacological, surgical, and non-invasive treatments. Objective: To improve the classification system for pain in dystonia. Design and setting: This are the preliminary results of a multicentric study that at this moment selects patients in the Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo and in the Hospital Sao Paulo da Universidade Federal de São Paulo. Methods: We evaluated 36 patients with hereditary/idiopathic dystonia of any distribution. These results are preliminary finds of this multicentric assessment. We applied the Burke-Fahn-Marsden (BFM) dystonia scale, two pain scales (Douleur Neuropathique - DN4 and the short-form Brief Pain Inventory - BPI), and our developed classification system. Results: Patients (54.9 ± 14.6 years, 41.7% male) had a BFM motor and disability subscores of 17.6 ± 6.8 and 4.5 ± 5.7, respectively, and 15 patients (41.7%) had chronic pain. Four patients had chronic pain non-related to dystonia, and 11 patients had chronic pain directly related to dystonia. Six patients had a second chronic pain, one of which was aggravated by dystonia, and five were directly associated with dystonia. DN4 was 2.1 ± 1.9, and BPI pain severity 5.2 ± 2.0 interference 5.0 ± 3.2. Conclusions: Chronic pain is prevalent in dystonic patients and is frequently directly related to dystonia.
Effect of transcranial direct current stimulation in the first weeks after stroke: a preliminary study
Authors: Takahashi Marcela Tengler Carvalho , Bázan Paulo Rodrigo , Balardin Joana Bisol , Boasquevisque Danielle de Sá , Amaro Júnior Edson , Conforto Adriana Bastos
Published: December 2021

Background: There is limited information about effects of transcranial Direct Current Stimulation(tDCS), delivered within the first weeks post-stroke, on performance of the paretic upper limb and on connectivity between motor areas in the affected and unaffected hemispheres. Objectives: We compared changes in Fugl-Meyer Assessment of Motor Recovery(FMA) scores, connectivity between the primary motor cortex of the unaffected(M1UH) and the affected hemisphere(M1AH), as well as between M1UH and the premotor cortex of the unaffected hemisphere(PMUH) before and after 6 sessions of cathodal tDCS targeting the primary motor cortex of the unaffected hemisphere(M1UH) early after stroke in 13 patients. Methods: This hypothesis-generating substudy was a randomized parallel, two-arm, double-blind, sham-controlled clinical trial performed at the Albert Einstein Hospital. Subjects were randomized active(N=6) or sham(N=7) groups. Results: Clinically relevant differences in FMA scores(≥ 9 points) were observed more often in the sham than in the active group. Between-group differences in changes in FMA scores were not statistically significant(Mann-Whitney test, p=0.133) but the effect size was -0.619(rank biserial correlation). Connectivity measures(Fisher’s z- transform of ROI-to-ROI correlations) between M1AH-M1UH increased in 5/6 participants in the active, and in 2/7 in the sham group after treatment. Between-group differences in changes in connectivity(M1UH-M1AH or PMUH-M1AH) were not statistically significant. In contrast with M1AH-M1UH connectivity, improvements in motor performance were more frequent in the active than in the sham group. Conclusions: Effects of cathodal tDCS on motor performance and on Resting-state Functional Magnetic Resonance Imaging may have distinct underpinnings in subjects at an early stage after stroke.
Cerebral venous thrombosis simulating cerebral arterial thrombosis: Late complication of COVID-19?
Authors: Lima Iana Campinho Braga de Araújo , Souza Lavínia Flávia Xavier de , Rosendo Clara Wilma Fernandes , Barradas Letícia de Freitas , Andrade Filho Emerson Kennedy Ribeiro de , Villarim Pedro Vilar de Oliveira , Siebra Gianluca Gomes , Câmara Ródio Luis Brandão , Fernandes Moisés Felipe da Costa
Published: December 2021

Context: Brain venous thrombosis (BVT) is uncommon and usually has a different clinic and treatment from cerebral arterial thrombosis. In this context, COVID-19 correlates with thrombogenesis with varied clinical repercussions. This report describes an unusual BVT case as a possible late complication of COVID-19. Case report: Male, 68 years old, athlete and healthy. April/2020: COVID-19 mild symptoms. February/2021: in road-running, he fell due to sudden left hemiparesis. Upon hospital admission: contacting, persistent headache. A week after, low level of consciousness and coma, when underwent right hemicraniectomy. Remains hospitalized. On examination: weak gestural communication, tracheostomy, enteral tube feeding, voluntary blinking. Maintains neutral cervical posture, masticatory automatisms, photoreactive isocoria, generalized rigidity, decorticated right hemiparesis, left hemiplegia. On imaging: hemorrhagic infarction on the right and mass effect due to obstruction of the Basal Rosenthal and Labbé veins and transverse sinus on the right, with venous blood flow in the rest of the hemisphere diverted to the ipsilateral internal jugular vein, by anastomotic veins of the occipital foramen and suboccipital venous plexus. Obstructed left internal jugular vein, with venous collateral flow from the left hemisphere via posterior intercavernous sinus and basilar plexus to the right internal jugular vein. Conclusions: To diagnose the venous etiology that resembled segmental occlusion of the right middle cerebral artery, CT angiography was required. Late evolution of COVID-19 has been identified by the persistence of symptoms for months. Although physical activity and possible dehydration may have contributed to BVT, a prothrombotic state correlated to COVID-19 cannot be discarded.
Epidemiological analysis of deaths and hospitalizations due to Alzheimer’s in Brazil from 2015 to 2019
Authors: Almeida Gabriella Ribeiro de , Martim Ana Júlia Omodei Rodrigues , Ramos Ana Maria Bezerra , Menezes Anniele Eline Lima , Papaléo Giovanna de Amorim , Albuquerque Mariany Piedade Almeida , Oliveira Nieclyson Alexandre de
Published: December 2021

Background: In 2050, Alzheimer’s disease (AD) may affect 14 million people worldwide, being considered the fourth leading cause of death in adults. Objectives: Analyze the variation in deaths, mortality rate and hospitalizations for AD from 2015 to 2019, in Brazil. Methods: We conducted a retrospective observational study of descriptive data from the Department of the Unified Health System (DATASUS). Results: In Brazil, from 2015 to 2019, there were 9045 hospitalizations and 1786 deaths from AD. Registering an increase in the total of dead about 75% (2015: n = 221; 2019: n = 386). In the years 2015-2019, the following mortality rates were recorded: 13.69; 14.86; 19.26; 21.23; 24,13, showing a smaller difference between the years 2015 and 2016 with 8.6%, and a greater difference between the deaths of 2016 and 2017 with 29%. Despite the growing trend of deaths from AD, there was a variation in the number of cases of hospitalizations in the analyzed period, with the following numbers per year, from 2015- 2019, respectively: 1,614; 1,501; 1,568; 1,550; 1,600, thus explaining that the year with the highest number of hospitalizations was 2015 (n = 1614), while the lowest was 2016 (n = 1501), showing a decrease between 2015-2019 of 0.86%. Conclusion: It was noted that 2019 had 165 more deaths than the year 2015 and a progressive increase in the mortality rate between 2015-2019. However, the number of hospitalizations during the study period was variable.
MentalPlus® as a Tool for Early Detection of Dementias
Authors: Santos Priscila , Pinto Daniel Godoy , Celestino Jussara Alves , Cisoto Marina
Published: December 2021

Introduction: The research’s objective is to identify early signs and symptoms of dementia through the MentalPlus® game. Dementias is a Neurocognitive Major Disorder, and as a diagnostic criterion, it is impaired in the areas of intricate attention, executive function, learning, memory, language, perceptomotor or social cognition. Method: MentalPlus® was created for timely evaluation and cognitive rehabilitation, considering the various diseases that cause cognitive dysfunction, such as dementia, heart problems, organic disorders, among others, in addition to surgical interventions and external factors. This instrument used to evaluate postoperative cognitive dysfunctions, which often affect elderly patients, confirms the validity and accessibility of the MentalPlus application. Results: Table 1 shows that the elderly in the group tested had statistically lower education than the control group (p < 0.001). Table 2 shows that for all domains of MentalPlus , on the hits part, the tested elderly group showed statistically lower values than the control group (p < 0.05), except only in the executive function (p = 0.231) and selective attention (p = 0.057), errors were also statistically higher in the elderly tested for almost all domains (p < 0.05), except in short-term memory (p = 0.206) and long-term memory (p = 0.179). At the same time, omissions were statistically higher in the elderly tested for all MP domains (p < 0.05). Conclusion: MentalPlus® identifies early signs of dementia in older people and is useful for the evaluator and the target audience, as it provides reliable data in a considerably short time.
Clinical and electrophysiological characteristics of the peripheral polyneuropathies from a single specialized center in the Southern Brazil
Authors: Tessaro Camila Lorenzini , Ducci Renata Dal-Prá , Kay Cláudia Suemi Kamoi , Fustes Otto Jesus Hernandez , Werneck Lineu César , Lorenzoni Paulo José , Scola Rosana Hermínia
Published: December 2021

Background: The peripheral polyneuropathies have etiological heterogeneity, with more than a hundred known causes. In addition, they have a lack of information related to their epidemiology. Objectives: The aim of this study is to determine the prevalence of each etiology of polyneuropathy in a single specialized center from Southern Brazil and to correlate main clinical manifestations and electrophysiological aspects. Design and setting: Observational cross-sectional study. Neuromuscular disorder center from a tertiary service. Methods: This study comprised individuals with electrodiagnostic tests compatible with polyneuropathy from a neuromuscular disorder center. Selected patients were those who underwent nerve conduction studies between 2008 and 2017. Through analysis of medical records, polyneuropathies were classified according to etiology and neurophysiological aspect. Results: The sample population consisted of 380 patients who has a male predominance (59.5%), with a median age of 43 years (26-57). The main etiologies were inflammatory (23.7%), hereditary (18.9%), idiopathic (13.7%), multifactorial (11.1%) and diabetes (10.8%). The main electrophysiological patterns were Axonal Sensorimotor Polyneuropathy (36.1%) and Demyelinating- Axonal Sensorimotor Polyneuropathy (27.9%). Idiopathic, diabetic, and multifactorial polyneuropathies had predominantly axonal pattern, while inflammatory and hereditary polyneuropathies had mainly demyelinating pattern. Conclusions: The frequency of inflammatory etiology was higher than previously described and frequency of diabetic polyneuropathy was lower. There may be a change in epidemiology of polyneuropathy in specialized centers, with a tendency to decrease idiopathic polyneuropathy. Electrodiagnostic testing is useful for etiological diagnosis since electrophysiological patterns correlate with specific etiologies.
A deletion in CFL-2 gene associated with Severe Nemaline Myopathy with peculiar features
Authors: Tieppo Eduardo Macedo de Souza , Koch Miriam Eva , Carvalho Alzira Alves de Siqueira
Published: December 2021

Context: Nemaline myopathy (NM) is the most common congenital myopathy characterized by muscle weakness and presence of nemaline bodies (rods) in muscle biopsy. Phenotype ranges from neonatal death to normal lifespan. 13 genes have been reported. We describe a new variant in cofilin 2 gene (CFL2;OMIM*601443). Case report: A 5-year-old boy born severely hypotonic and unable to breathe, in need of mechanic ventilation. Healthy non-consanguineous parents. Physical examination: severe hypotonia with only extraocular motricity preserved and multiple contractures. Dysmorphic features were observed as brachycephaly, hypertelorism, pseudohypertrophy, macroglossia, premature pubic hair. Deep reflexes were absent. CK: 1010U/l. DHEA-S elevated. Muscular biopsy: Rods, cores and dystrophic pattern. Exome: homozygous deletion in exons 1 to 4 of CFL2 and partial deletion of the next gene Sorting nexin-6 (SNX6) in Chr14:34.563.122-34.714.639. Conclusion: 9 cases were described previously: Age onset was before 31 months. 4 presented respiratory distress at birth, 1 presented macroglossia, 2 contractures, 2 spinal deformities and 3 delayed motor milestones. Our patient presents an extent deletion in homozygosis not described before. A second deletion was found in SNX6, which is involved in protein trafficking and is expressed in different cells, as endocrine and cardiac. The early puberty and dimorphisms could be due to SNX6, though there is no previous disease caused by this gene. Among differential diagnosis of macroglossia, congenital myopathy caused by CFL2 should be considered.
App prototype for telehealth of patients with Traumatic Brain Injury – Startups in neurology
Authors: Oliveira Izabella Pereira de , Perucelo Letícia Leal , Carvalho Yullie Inaiêh Procópio de , Aquino Leticia Moraes de
Published: December 2021

Background: Traumatic Brain Injury (TBI) is a brain insult caused by an external mechanical force that can lead to physical, behavioral and cognitive chronic deficitsneedingmultiprofissionalteamrehabilitation. With the Covid-19 pandemic, many individuals with disabilities had reduced access and continuity of health care, making telehealth appear as an opportunity. Design and settings: This study is being developed and incubated at University Center São Camilo- SP. Objectives: To develop a continuous health care app for this patients, conecting them with professionals. Methods: Search Information on main health databases in telehealth and TBI for the development of an app prototype. Results: An app prototype as a tool of continous treatment for patients with TBI; to offer a virtual and individual service, assisted by a multiprofessional team. Professionals and patients can register in the app, after an initial process. On the experimental period, patients can get simple evaluation of funcionality and general exercises (as an introduction to online home care). After this period, a month fee will be charge, and they will be directed to contact professionals, with the possibility of online continuity or face-to-face scheduling. Conclusion: telehealth, through a simple app, can guarantee continuity of care, reducing travel, and connecting professionals.
Analysis of the admissions and deaths in the Brazilians Regions by Viral Meningitis in the last decade
Authors: Bernich Natali Rocha , Oliveira René Ochagavia Chagas de , Busin Isabella Montemaggiore , Guglielmi Vanessa Saling , Redmann Lucas Henrique Skalei , Silva Bianca Brinques da , Falcetta Julia Estrazulas , Ferrari Gabriela Kreutz , Fassina Vitória , Paglioli Victoria Bento Alves , Affonso Ana Laura Terra , Toffoli Laura , Roehrig Julia Bortolini , Soares Bruna Martins de
Published: December 2021

Background: Viral meningitis is a neuroinfection that presents neurological alterations that usually evolve benignly. In Brazil, during the last decade, the disease caused 30,731 admissions and 1,048 deaths. Objectives: Analyze the number of hospital admissions for Viral Meningitis, between from 2011 to 2021 in all the regions of Brazil. Design and setting: Study realized using data from the Department of Information of the Brazilian Health System (DATASUS). The variables researched were hospitalizations, deaths, age, gender, race e Brazilian regions. Results: The regions with the highest number of admissions for viral meningitis are the Southeast (42.51%), followed by the Northeast (24.07%) and the South region (22.10%).It was observed that, in all age groups analyzed, males constitute the majority of admissions (58%). In terms of race, 37.51% were white and 28.41% were brown. In the case of deaths (1,048 in total), men were the majority. The mean length of hospital stay was 7.4 days and the average cost was R $1,119.07. Conclusion: Male, white, and aged between 1 and 4 years old are the characteristics that form the profile of the patient frequently hospitalized for Viral Meningitis. The region of Brazil with the highest number of admissions was in the Southeast and the one with the lowest was the North region. Regarding the number of deaths, it is higher in males.
INTEGRACIÓN DE LAS TERAPIAS COMPLEMENTARIAS EN LA FORMACIÓN DE ENFERMERÍA: PERCEPCIÓN DE LOS ESTUDIANTES
Authors: Abarca Gonzalez Esmeralda , Ibarra Torres Ignacio , Lara Segovia Vicente , Vega Vega Paula
Published: December 2021

Objetivo: Comprender el significado que tiene para estudiantes de pregrado de enfermería el realizar

un curso en base a las prácticas complementarias. Metodología: Investigación cualitativa descriptiva en

base al análisis de contenido temático de Krippendorff. Se realizó un cuestionario de autorreporte a 80

estudiantes de enfermería, quienes participaron del curso optativo “Cuidados Complementarios en

Salud”, entre los años 2014 y 2018, donde se preguntó: “¿qué significó para ti participar en un curso en

base a las terapias complementarias?”. Las narrativas transcritas literalmente fueron sometidas a un

análisis de contenido cualitativo inductivo por los investigadores, develando las categorías tras su

saturación. Resultados: Los significados que los estudiantes le atribuyen a su participación en el curso

son: Expandir mi conocimiento sobre las terapias complementarias, Tomar conciencia de nuestra vida,

Ser una instancia de crecimiento personal, Considerar la incorporación de las terapias

complementarias en enfermería y Valorar la integralidad de las medicinas. Conclusiones: El curso les

permitió a los estudiantes tomar conciencia de su propio autocuidado y transformar la experiencia en

una instancia de crecimiento personal. Además, los estudiantes consideran necesario aprender sobre las

terapias complementarias en pregrado y así adquirir herramientas que les permitan integrar ambas

medicinas para el cuidado de la persona y comunidad.
JÓVENES UNIVERSITARIOS ESTILOS DE VIDA Y BIOLOGÍA HUMANA. ¿PREDISPONEN AL DESARROLLO DE ENFERMEDAD CARDIOVASCULAR?
Authors: Mendoza Silva Yorman Orlando , Moreno Rodríguez Aaron Ricardo , Zambrano Plata Gloria Esperanza , Ruiz Roa Silvia Liliana
Published: December 2021

Introducción: Las enfermedades cardiovasculares han despertado interés en los últimos años por su alta incidencia a nivel mundial, generando 17,9 millones de muertes a nivel global, a pesar de que estas patológicas tienen poca prevalencia en poblaciones jóvenes, se sabe que desde edades tempranas se van produciendo cambios estructurales y funcionales en la red vascular y cardiaca derivados de conductas inadecuadas en salud relacionadas al estilo vida y aspectos biológicos propios de cada individuo. Objetivo: La investigación tiene como objetivo determinar los estilos de vida y los aspectos biológicos de los estudiantes de enfermería que pueden influir en el desarrollo de enfermedad cardiovascular. Metodología: Investigación cuantitativa descriptiva de corte transversal, con un muestreo a conveniencia donde participaron 100 estudiantes, se utilizaron instrumentos validados y estandarizados como el CEVJU-II, SISCO-SV-21 y datos de valoración física y bioquímica sanguínea. Resultados: La edad promedio de los estudiantes fue de 21 años, en su mayoría población femenina. Los estudiantes presentaron conductas no saludables en los estilos de vida: actividad física, alimentación, sueño, consumo de alcohol, cigarro y drogas ilegales, y estrés moderado. El principal antecedente familiar fue la hipertensión arterial, sin embargo, las alteraciones antropométricas, presión arterial, lípidos y glucosa sanguínea no tuvieron altas prevalencias. Conclusiones: Se concluye que a pesar de que la mayoría de los jóvenes universitarios mantienen conductas no saludables en los estilos de vida, estos comportamientos a edades tempranas no se manifestaban en cambios antropométricos y bioquímicos, lo que reduce el riesgo de presentar enfermedades cardiovasculares a futuro.
MISSÃO, REINO E IGREJA DE DEUS: ALINHANDO E COSTURANDO OS CONCEITOS
Authors: Souza Clayton Lima de , Dück Arthur Wesley
Published: December 2021

RESUMOEste artigo é uma apresentação resumida dos conceitos de “Missão de Deus” (missio Dei), “Reino (ou reinado) de Deus” e “Igreja”. Isto foi feito de acordo com os textos bíblicos e com a literatura teológica produzida por diversos estudiosos no assunto, com o objetivo de compreende-los individualmente e entender como se inter-relacionam. Na presente pesquisa, constatou-se que a missão não é do indivíduo cristão e nem da igreja, mas que ambos são convidados a participar da missão em que Deus se empreendeu. Essa missão, iniciada logo depois da queda e que permeia todo o texto bíblico e consequentemente, toda a história da igreja, compreende o estabelecimento do seu reinado no mundo, não somente sobre o indivíduo, mas também sobre as instituições com o objetivo de restaurar tudo o que foi corrompido pelo pecado. Para tal, a igreja é a sua ferramenta de trabalho.PALAVRAS CHAVE: Missão; Missão de Deus; Reino de Deus; Igreja; Igreja; Restauração.
BULLYING NA ESCOLA E NA FAMÍLIA: CAPELANIA COMO ALTERNATIVA PREVENTIVA E CORRETIVA
Authors: Oliveira Josué de , Silva Neir Moreira da , August Fridbert
Published: December 2021

O bullying é um fenômeno presente no dia a dia da escola, sendo comum e muitas vezes não tendo a atenção devida por parte dos envolvidos. Neste estudo será trabalhado sobre o fenômeno bullying, seus conceitos de violência, na escola, na família, suas causas, suas consequências e possíveis soluções, tanto para a escola, quanto para a família.
PASTORES TAMBÉM SÃO OVELHAS - IMPORTANDO-SE PARA CUIDAR DAQUELES QUE CUIDAM
Authors: Wedel Siegfrid , Dück Arthur Wesley
Published: December 2021

Este artigo ocupa-se com a pessoa do pastor da igreja como ser humano, tendo em vista suas crises ministeriais e pessoais. O pastor como cuidador de pessoas é abordado na perspectiva de que o mesmo é, também, uma ovelha entre ovelhas. A dimensão de cuidar e de ser cuidado é amplamente discutida e avaliada. Destaca-se a importância do cuidado pessoal e pastoral que deve ser proporcionado ao pastor como pessoa. No primeiro capítulo são esboçadas algumas crises e armadilhas que justificam esta necessidade urgente dos agentes pastorais. No segundo são apresentados os desafios que este cuidado envolve tanto para a igreja quanto para o próprio pastor. Uma pesquisa de campo com 81 pastores confirma e atesta a necessidade e a importância de um pastoreio e mentoreamento de pastores. No terceiro capítulo são apresentadas várias iniciativas de cuidados voltados intencionalmente para a pessoa do pastor. O pastor pode e deve ser cuidado. Há um clamor por “pastor de pastores”.
DESIGREJADOS NA COLÔNIA WITMARSUM
Authors: Pauls Siegfried , Dück Arthur Wesley
Published: December 2021

O objetivo deste artigo é apresentar formas de aproximação da igreja para com os desigrejados da Colônia Witmarsum. Para isso utiliza-se a metodologia de pesquisa qualitativa, recorrendo-se antes, na parte teórica, ao auxílio de autores como Bomilcar (2012) e Burke (2006). As áreas trabalhadas na pesquisa de campo, definidas após uma entrevista com um líder da comunidade local foram: (1) Finanças; (2) Exclusão Social; (3) Testemunho Pessoal; e (4) Competição.  Constatou-se que uma das principais razões para o afastamento de pessoas da instituição eclesiástica é o desapontamento daquelas para com esta. Sabendo disso, propõe-se que haja um equilíbrio entre ambas as partes: por parte dos desigrejados, o reconhecimento de que a igreja é formada por pessoas falhas; por parte da igreja, o compromisso de ser exemplar em sua conduta.
LEARNING FROM THE PAST: THE USEFULNESS AND CHALLENGES OF ONLINE LEARNING
Authors: Ida Bagus Nyoman Mantra  , I Gusti Ayu Putu Tuti Indrawati  , I Nyoman Suwandi  , Ni Luh Sukanadi  , Anak Agung Rai Laksmi
Published: December 2021

Recently online learning has been developed widely in Indonesia and most of the education institutions implemented online learning during the covid-19 pandemic. The purpose of online learning is to facilitate communication in the delivery of teaching materials in the field of education that is carried out remotely. It is generally intended for non-face-to-face teaching methods. This study was conducted to investigate the usefulness and the challenges encountered by the teachers in implementing online learning. This study made use of qualitative research design with descriptive analysis and to collect the data semi-structured interviews and online classroom observations were conducted to collect valid and reliable data. This study found that there was the usefulness of online learning which benefits students to improve their competence and also there were a number of challenges encountered by the teachers. Therefore, this study implies that teachers should acknowledge the challenges of online learning to create a better online learning activity.
Pengaruh Media Pembelajaran CD Interaktif Melalui Pembelajaran Daring di Era Pandemi Covid-19 Terhadap Hasil Belajar IPA
Authors: Pobela Sry Rahayu , Rungkat Jovialine A.
Published: December 2021

Penelitian ini bertujuan untuk melihat pengaruh media pembelajaran CD interaktif melalui pembelajaran daring di era pandemi Covid-19 terhadap hasil belajar pada mata pelajaran IPA di SMP Negeri 7 Kotamobagu. Penelitian ini merupakan penelitian eksperimen semu menggunakan rancangan pretest posttest randomized two group design. Populasi dalam penelitian ini adalah seluruh kelas VIII di SMP Negeri 7 Kotamobagu dan sampel penelitian terdiri dari 2 kelas, yaitu kelas VIII A sebagai kelas eksperimen yang berjumlah 32 siswa dan kelas VIII B sebagai kelas kontrol yang berjumlah 27 siswa. Pengambilan data dilakukan dengan memberikan pretest sebelum diberikan perlakuan dan posttest sesudah diberikan perlakuan. Hasil penelitian yang diperoleh berupa selisih nilai rata-rata hasil pretest dan posttest pada kelas eksperimen sebesar 48,28 sedangkan untuk kelas kontrol 33,15. Setelah diuji statistik melalui uji-t, rata-rata hasil belajar yang didapat antara kelas kontrol dan kelas eksperimen diperoleh thitung = 10,58 > ttabel = 2,004. Dengan demikian dapat disimpulkan bahwa terdapat pengaruh media pembelajaran CD interaktif melalui pembelajaran daring di era pandemi Covid-19 terhadap hasil belajar pada mata pelajaran IPA di SMP Negeri 7 Kotamobagu
Las Representaciones Sociales de los estudiantes de Pedagogía en Historia y Ciencias Sociales de la Universidad de Santiago de Chile, en su proceso de formación inicial
Authors: Valencia Castañeda Lucía
Published: December 2021

La investigación indaga en las representaciones sociales que poseen los estudiantes de la carrera de Pedagogía en Historia y Ciencias Sociales de la Universidad de Santiago de Chile, sobre el oficio de profesor de historia y sobre la historia y las ciencias sociales como disciplinas y como materias de enseñanza escolar. A partir del análisis de las respuestas a un cuestionario desarrollado por dos conjuntos de estudiantes: los recién ingresados en su primera semana de experiencia universitaria; y los integrantes del grupo de la última práctica profesional, en su décimo semestre de formación, se aproximan conclusiones relativas al origen de las representaciones sociales que poseen los estudiantes en los aspectos antes referidos y de la influencia que ha tenido en ellas su formación universitaria.