bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluasi dan Perencanaan Ulang Instalasi Pengolahan Air Limbah (IPAL) Industri Pembekuan Ikan PT. X Kabupaten Sidoarjo
Authors: Afrianisa Rodu Dhuha , A’yunin Qurrotu
Published: September 2024

Sektor perikanan merupakan salah satu sektor perekonomian utama di Kabupaten Sidoarjo. PT. X merupakan industri yang menghasilkan produk ikan beku. PT. X sudah memiliki Instalasi Pengolahan Air Limbah, namun effluen IPAL yang dihasilkan belum memenuhi baku mutu. Berdasarkan permasalahan tersebut maka diperlukan evaluasi IPAL, kemudian dilakukan perencanaan ulang IPAL agar effluen yang dihasilkan memenuhi baku mutu. Evaluasi dilakukan dengan menganalisis sampel air limbah dari tiap unit IPAL, mengukur dimensi dari tiap unit IPAL, dan membandingkan parameter waktu detensi dengan kriteria desain. Hasil evaluasi menunjukkan bahwa kondisi eksisting IPAL tidak memenuhi kriteria desain dan hasil effluent IPAL eksisting belum memenuhi baku mutu berdasarkan Peraturan Gubernur Jawa Timur No 72 Tahun 2013. Rekomendasi dari hasil evaluasi yaitu perencanaan ulang IPAL menggunakan sistem Anaerobik-Aerobik filter. Unit yang digunakan yaitu screen, bak ekualisasi, bak pengendap awal, bak anaerobik filter, bak aerobik filter, dan bak pengendap akhir. IPAL direncanakan untuk mengolah air limbah dengan debit 3 m 3 /hari dan
karakteristik air limbah yaitu TSS 179 mg/L; BOD 239 mg/L; COD 586 mg/L; dan Ammonia 29 mg/L. Dimensi
IPAL yang didapatkan yaitu 6m x 1m x 1,5m.
Online Child Sexual Exploitation and Abuse (OCSEA) of children and adolescents: A Systematic Literature Review
Authors: Novianti Novianti
Published: September 2024

This study concerns the issue of online child sexual exploitation and abuse (OCSEA) of children and adolescents. This study aims to identify the vulnerability factors of children and adolescents exposed to OCSEA and the measures to prevent and overcome this problem. The systematic literature review method was used including the formation of PICO, language terminology, inclusion and exclusion criteria, and data selection through PRISMA. The literature review found OCSEA vulnerability factors caused by a young age, perception, communication, economy, accessibility, emotional stability, population, gender, parental supervision, and children's internet knowledge. The handling is still at the stage of developing a framework, although there are relevant policies, but it is necessary to make new comprehensive laws to deal with OCSEA more explicitly. The limited prevalence and evidence related to the OCSEA problem led this study to take the initiative to conduct a literature review aimed at understanding the concept, development, and context of online child sexual exploitation and abuse.
Job Stress and Turnover Intention in Generation Z Teachers: Resilience as a Moderator
Authors: Lubis Rahmi , Syafitri Nellinda , Alyani Nurin Nadhira , Maylinda Risky Nurlita , Anda Riski , Zulfiyanti Novi
Published: September 2024

Teaching is a demanding profession that can jeopardize the physical and mental health of teachers. Generation Z teachers, born between 1995 and 2009, are innovative, flexible, and adaptive in the teaching approach but dislike complicated rules and tend to change job, resulting to increased turnover intention. One of the predictors affecting turnover intention is job stress, an aspect that has not been previously explored. Therefore, this correlational quantitative study aimed to investigate the role of resilience in determining the magnitude of the effect of job stress on turnover intention. The participants were 170 Generation Z teachers from private elementary schools in District X Medan. The study instrument included job stress scale adapted from Dinyati (2019), turnover intention scale from Bothma & Roodt (2013), and resilience scale from Connor and Davidson (2003). The SEM test results showed that resilience played a crucial role in determining the strength of the effect of job stress. The effect of stress on turnover intention decreased with increase in resilience and vice versa.
NICKEL BASED METAL CARBIDES AS ELECTROCATALYSTSFOR METHANOL OXIDATION REACTION
Authors: Ullah Nabi , Guziejewski Dariusz , Khan Sumiara Irum , Muhammad Noaman , Ullah Atta , Rahayu Farida
Published: September 2024

Effective catalysts play a crucial role in enhancing methanol oxidation within fuel cells. In light of this, diverse catalysts have undergone examination; however, recently, significant research interest has turned towards Ni-based metal carbides. Their appeal lies in their cost-effectiveness, high activity, and notably, the presence of metal-carbon bonds. These bonds are formed due to carbon's s- and p-hybridization with the metal d orbitals. This combination heightens the d band activity of the metal, akin to that of Pt, as suggested by DFT approximations. The catalytic potential can be further augmented through the amalgamation of metal carbides with other active materials. Furthermore, refining the catalyst's size and morphology has the potential to enhance its electrochemical application for methanol oxidation. This involves maximizing the active surface area by optimizing its morphology and increasing the availability of metal carbide atoms. The introduction of multiple metals to metal carbides or the incorporation of multi-metal-based electrocatalysts onto the metal carbide's surface is also an area of fervent exploration. Such endeavors hold the promise of enhancing activity and devising economically viable for methanol oxidation based fuel cells.
Prevalence and Factors Associated with Food Insecurity in Indigenous Families in the State of Alagoas (Northeast Brazil): A Population-Based Cross-Sectional Study
Authors: Almeida Élison Ruan da Silva , Santos Tamara Rodrigues dos , Fávaro Thatiana Regina , Santos Ewerton Amorim dos , Ferreira Haroldo da Silva
Published: September 2024

Despite recent efforts by the government to combat Food Insecurity (FI), this issue remains a significant problem in Brazil, particularly among populations experiencing social vulnerability, such as Indigenous peoples. This study aimed to assess the prevalence and factors associated with FI in Indigenous families in the state of Alagoas. It was a population-based cross-sectional survey using a probabilistic sample (n=1270 families) representing the 11 ethnic groups present in the state. FI was defined according to the Brazilian Food Insecurity Scale. Factors associated with moderate and severe FI were determined through multivariable analysis using Poisson regression with robust variance adjustment (prevalence ratio – PR and 95% CI). The prevalence of FI was 69.1%, with 29.5% in moderate (23.2%) and severe (6.3%) forms. Factors associated (p
The Current State of Cell Viability Methods
Authors: Madorran Eneko
Published: September 2024

Cell viability refers to the proportion of living, healthy cells within a given population. This information is crucial in any cell-based research, especially in toxicology. Over the past century, numerous methods for assessing cell viability have been developed. These methods can be categorized into five main types: non-invasive cell structure damage, invasive cell structure damage, cell growth, cellular metabolism, and cell membrane potential. Each method operates on different principles and has its own advantages and disadvantages, making it essential for researchers to choose the method that best fits their experimental design. Despite the variety of cell viability methods available, most rely on indirect measurements of cell viability, which may compromise their accuracy. In this sense, there is insufficient information regarding their accuracy, highlighting the need for researchers to investigate the accuracy of both existing and future methods.
Commercialized “Smudge Sticks” Used as Incense in the Netherlands: An Inventory of Plants and Trends behind a New Age Fashion
Authors: Pombo Geertsma Isabela , Zandstra Berber E. , Stefanaki Anastasia , van Andel Tinde R.
Published: September 2024

Incense is essential in religious ceremonies, even in relatively new religious movements such as New Age and Neopaganism. These garner little attention from ethnobotanists, although they trigger an international trade in wild-harvested plants. In this paper, we studied the botanical ingredients of smudge sticks (dried plant bundles burned for purification) in the Netherlands, and people’s motivations to use them posing the following questions: what plant species are included in smudge sticks? what are they used for? and are exotic plants preferred over native Dutch plant species?
We visited online and physical shops in Dutch cities, acquiring a total of 29 different smudge sticks containing at least 15 species. We held semi-structured interviews with 11 users, vendors, and herbal experts, and collected data from 33 questionnaires. Salvia apiana L. was most frequently found, along with North American species of the genus Artemisia.
The rise of the New Age movement resulted in North American ritual plant species being easily available in (online) shops and it being used for personal protection and cleansing. Despite its commercial demand there is no data regarding the pressure on wild populations, therefore, we call for the need to monitor the harvesting of these species in the wild.
Hydrogen Production from Biomass on an Industrial Scale
Authors: Tungal Richa , Kaur Rehmat
Published: September 2024

Hydrogen is increasingly recognized as a crucial element in the shift toward sustainable energy systems due to its high energy density and minimal environmental impact. Biomass, a renewable material derived from plants and animals, presents a promising feedstock for hydrogen production, offering both environmental and economic benefits. This paper examines diverse biomass resources for hydrogen production, including agricultural and forest residues, dedicated energy crops, and organic waste. It reviews key technologies for converting biomass to hydrogen, categorized into thermochemical, biochemical, and hybrid processes. Thermochemical methods like gasification and pyrolysis are discussed for their ability to handle varied feedstocks and produce high-purity hydrogen. Biochemical processes, such as anaerobic digestion and dark fermentation, are analyzed for their efficiency and lower operational costs. Hybrid approaches, which integrate multiple technologies, are explored for their potential to enhance system performance. Industrial applications of biomass-derived hydrogen are highlighted, including its use in transportation, power generation, the chemical industry, and heating. Future perspectives emphasize the need for advanced catalysts, process integration, sustainable feedstock sourcing, and supportive policies to drive commercial viability. The paper concludes by highlighting biomass’s significant promise in advancing sustainable energy systems and achieving global energy security and environmental goals.
TMining: Detecting Fake News with Machine Learning and Explainable AI
Authors: Lupei Maksym , Shliakhta Myroslav
Published: September 2024

The spread of false information can significantly harm public opinion, underscoring the importance of accurately identifying untrustworthy news. This paper presents an innovative machine learning (ML) tool, TMining, designed to evaluate news credibility and facilitate various text-mining tasks. By examining a range of ML methodologies alongside preprocessing techniques, we aim to boost the system's effectiveness. Our research meticulously assesses different datasets, highlights the impact of applying stemming techniques, and employs Local Interpretable Model-Agnostic Explanations (LIMEs) to shed light on the rationale behind model predictions. The outcomes reveal a notable enhancement in both the precision and clarity of the news verification process. The ultimate version of the model has been made available as an Application Program Interface (API), and its source code has been shared openly, encouraging further exploration and collaboration within the scientific community. This initiative advances our ability to discern manipulative context from fictitious content and promotes transparency and understanding in the domain of ML applications.
Harnessing Chitosan Beads as an Immobilization Matrix for nZVI for the Treatment of Cr(VI) Contaminated Laboratory Residue
Authors: Rychluk Ignacio Daniel , Casado Ulises , Montesinos Víctor Nahuel , Quici Natalia
Published: September 2024

Nanocomposites (NCs) consisting of zero-valent iron nanoparticles (nZVI) immobilized in chitosan (CS) were prepared and employed, for the removal of hexavalent chromium (Cr(VI)) from both synthetic and real wastewater. Medium (MCS) and high (HCS) molecular weight chitosan and stabilization with carboxymethylcellulose (CMC), and different nZVI load were explored. Characterization through Scanning Electron Microscopy with Energy Dispersive X-ray Analysis (SEM-EDS) and X-ray Diffraction (XRD) revealed millimeter-sized spheres with micrometer-sized nZVI clusters randomly distributed. Better nanoparticle dispersion was observed in NCs from the CMC-MCS and HCS combinations. Fourier-transform infrared spectroscopy (FTIR) analysis indicated that CS binds to Fe(II) or Fe(III) on the surface of nZVI through its functional groups -CONH-, -N-H and -C-OH and through the -COO- functional group of CMC, forming a bidentate bridge complex. Through experiments with synthetic waters, it was found that the elimination of Cr(VI) is favored by lowering the pH, obtaining the maximum percentage of Cr(VI) removal at pH 5.5. With real waters, it was shown that increasing the mass of NCs also improves the removal of Cr(VI), following a pseudo-second-order adsorption kinetics. The synthesized materials show great potential for applications in environmental remediation, showing good efficiency in the removal of Cr(VI) in wastewater.
Machine Learning Discoveries of Bcl-X Synergy in etc-1922159 Treated Colorectal Cancer Cells
Authors: Sinha Shriprakash
Published: September 2024

Often, in biology, we are faced with the problem of exploring relevant unknown biological hypotheses in the form of myriads of combinations of factors/genes/proteins that might be affecting the pathway under certain conditions. In colorectal cancer (CRC) cells treated with ETC-1922159, many genes were found up and down regu- lated, individually. A recently developed search engine ranked combinations of BCL-X (X, a particular gene/protein) at 2nd order level after drug administration. These rank- ings reveal which BCL-X combinations might be working synergistically in CRC. If found true, oncologists can further test the combination of interest in wet lab and deter- mine the mechanism of functioning between the BCL and X. In this research work, we cover combinations of BCL with Interleukin (IL), Selenbp1, TP53, caspase (CASP), mucin (MUC) and exosome (EXOSC).
Development and Pilot Study of myfood24 West Africa — an Online Tool for Dietary Assessment in Nigeria
Authors: Uzokwe Chinwe Adaugo , Nkwoala Chiaka Charles , Ebenso Bassey , Beer Sarah , Williams Grace , Iheme Gideon , Opara Chihurumnanya , Sanusi Rasaki , Ene-Obong Henrietta Nkechi , Cade Janet E
Published: September 2024

Background/objective: Tools to accurately and efficiently measure the dietary intake of Nigeria are lacking. We aimed to develop and assess the usability of a new online dietary assessment tool for Nigeria, myfood24 West Africa.
Methods: We developed myfood24 West Africa database using data from existing food composition tables, back-of-pack labels of packaged foods and research articles. A 7-step approach was used: identified data sources, selected foods, processed/cleaned data, calculated nutrient content of recipes, created/allocated portion sizes, quality-checked database, and developed food accompaniments. To pilot myfood24 West Africa, we recruited 179 university staff living in Nigeria using a cross-sectional design; usability was assessed using a questionnaire that incorporated the System Usability Scale (SUS) and feedback session.
Results: The database included 924 foods with up to 54 nutrients and 35 portion-size images allocated to foods. 60% of the data were sourced from the 2019 West Africa Food Composition Table, 17% from back-of-pack labels, 14% from the 2017 Nigeria Food Composition Table, 5% from generated recipes and 4% items from published literature. 30% (n=53) self-recorded their diet on their own and 1345 entries were made. The mean SUS score of 74 (95% CI: 68,79) indicated good usability. The feedback showed the tool was easy to use, educative, and included a variety of locally foods consumed.
Conclusion: This new tool will enhance the dietary assessment of the Nigerian population. More work will cover more foods from other regions of Nigeria and West African countries.
Low Levels of Burnout Among Advanced Care at Home Providers at Mayo Clinic
Authors: Gomez-Cabello Cesar Abraham , Maita Karla C , Borna Sahar , Haider Syed Ali , Genovese Ariana , Prabha Srinivasagam , Forte Antonio Jorge , Maniaci Michael J
Published: September 2024

Burnout in healthcare affects the quality of patient care. In 2020, Mayo Clinic implemented Advanced Care at Home (ACH), a new hospital-at-home program. We aimed to assess burnout levels among ACH providers, analyzing data from quarterly surveys. Physicians and nurse practitioners registered in ACH completed a 16-question anonymous survey distributed via email. Ten questions from the original survey used the Maslach Burnout Inventory to measure the three domains associated with burnout: depersonalization, emotional exhaustion, and personal achievement. We conducted a descriptive analysis using frequency distribution and percentages. A total of 27 providers participated, with response rates of 38%, 23%, and 66% in the first, second, and third quarters. Over 75% of the participants responded satisfactorily to nine of the ten questions associated with the risk of burnout. Moreover, 77% of providers felt joyful at work "always or most of the time." Of the 74% of participants who responded to the question about feeling burned out from work, 48% of the participants "strongly” or “somewhat” disagreed, while only 26% "strongly” or “somewhat” agreed. Mayo Clinic's ACH has demonstrated low levels of burnout among providers, positively impacting the well-being of healthcare workers and contributing to a high standard of patient care.
Machine Learning Discoveries of DNA Repair-X Synergy in ETC-1922159 Treated Colorectal Cancer Cells
Authors: Sinha Shriprakash
Published: September 2024

Often, in biology, we are faced with the problem of exploring relevant unknown biological hypotheses in the form of myriads of combinations of factors/genes/proteins that might be affecting the pathway under certain conditions. In colorectal cancer (CRC) cells treated with ETC-1922159, many genes were found up and down regu- lated, individually. A recently developed search engine ranked combinations of DNA repair gene-X (X, a particular gene/protein) at 2nd order level after drug administration. These rankings reveal which Wnt-X combinations might be working synergistically in CRC. If found true, oncologists can further test the combination of interest in wet lab and determine the mechanism of functioning between the Wnt and X. In this re- search work, we cover combinations of RAD with X-ray repair cross complementing (XRCC) family, 5’-3’ exoribonuclease 2 (XRN2), NFKB repressing factor (NKRF), B cell CLL/lymphoma (BCL) family, exosome component (EXOSC) family, FA comple- mentation group (FANC) family and XRCC with EXOSC.
The Association between Dietary Vitamin C and Sleep Disorders: A Cohort Study Based on UK Biobank
Authors: Zhang Qiuge , Qi Xueting , Wang Zhaoguo , Zhang Dongfeng , Wang Tong
Published: September 2024

There are few longitudinal studies on the association between dietary vitamin C and sleep disorders. The aim of this study was to investigate the association between dietary vitamin C intake and various types of sleep disorders, including sleep apnea and insomnia, as well as recommended dietary intakes. A total of 68,221 participants from the UK Biobank were enrolled in the study. Dietary vitamin C intake was calculated by a 24-hour dietary recall questionnaire. We used Cox regression model to assess the association between dietary vitamin C and sleep disorders and restricted cubic spline models to explore potential nonlinear relationships. Stratified analyses and sensitivity analyses were also performed to further test the results. The results showed that vitamin C intake at the Q4 level (132.88-191.51 mg/d) was significantly protective against sleep disorders with an HR (95% CI) of 0.78 (0.65-0.94), and against sleep apnea with an HR (95% CI) of 0.75 (0.62-0.92). The protective effect remained significant in stratified analyses of men and age ≤60 years, and the results were robust in sensitivity analyses. Adequate dietary vitamin C intake may have a protective effect in preventing sleep disorders.
Exploring the Therapeutic Potential of N-Methyl-D-Aspartate Receptor Antagonists in Neuropathic Pain Management
Authors: Pușcașu Ciprian , Chiriță Cornel , Negreș Simona , Blebea Nicoleta Mirela
Published: September 2024

Neuropathic pain (NeP) is a complex and debilitating condition that impacts millions of people globally. Although various treatment options exist, their effectiveness is often limited, and they can be accompanied by significant side effects. In recent years, there has been increasing interest in targeting the N-methyl-D-aspartate receptor (NMDAR) as a potential therapeutic approach to alleviate different types of neuropathic pain. This narrative review aims to provide a comprehensive examination of NMDAR antagonists, specifically ketamine, memantine, methadone, amantadine, carbamazepine, valproic acid, phenytoin, dextromethorphan, riluzole, and levorphanol, in the management of NeP. By analyzing and summarizing current preclinical and clinical studies, this review seeks to evaluate the efficacy of these pharmacologic agents in providing adequate relief for NeP.
Comprehensive Phylogenetic and Immunogenic Analysis of SARS-CoV-2 and Related Coronaviruses
Authors: Owusu Ansah Emmanuel , Fosu Kwadwo , Abonyi Mensah Theophilus , Plas Otwe Emmanuel , Sakyi Agyirifo Daniel
Published: September 2024

The continues evolution of coronaviruses has gained considerable attention prior to the outbreak of COVID 19. Although, COVID-19 is currently not recognized as a global pandemic, the virus's ability to evolve and cause disease outbreaks in both humans and animals necessitates ongoing research into its genetic and structural characteristics. Therefore, understanding the molecular origin, rapid evolution, as were as the immunogenicity of coronaviruses is a critical step towards preparing for and preventing future outbreaks. This study aimed to uncover the genetic diversity and evolutionary relationships among the main viral proteins of SARS-CoV-2 and other related coronaviruses. Amino acid sequences of structural viral proteins spike glycoprotein, nucleocapsid protein, membrane protein, and envelope protein were retrieved from the NCBI database for SARS-CoV-2 and 13 other coronaviruses. Here, we identified that SARS-CoV-2 is closely related to BatCoV RaTG13 and Pangolin-CoV, suggesting their potential role in the emergence of the virus. Additionally, we predicted novel epitopes, glycosylation sites, and cleavage sites, identifying three novel glycosylation sites (NATR, NXSN, and NGTK) and six new CTL epitopes (XSNQVAVLY, NSFTRGVYY, NATRFASVY, STQDLFLPF, NSASFSTFK, and ASFSTFKCY). Our comparative analysis revealed that BatCoV RaTG13 has the closest cleavage site to SARS-CoV-2, with significant similarities also observed with Pangolin-CoV. The study highlighted the unique features of SARS-CoV-2, including its furin cleavage site, which may account for its high infectivity during the pandemic. These findings contribute to the understanding of SARS-CoV-2 evolution and its relationship with other coronaviruses, providing critical insights for the development of broad-spectrum vaccines and antiviral therapies.
Endothelin-1 as an Activator of Pro-inflammatory Microglia Cells
Authors: Inostroza-Nieves Yaritza , Bou Shakira , Alvarado-Perez Jose , Capo-Ruiz Diego , Garcia Jessica , Moliere Jean P , Arenas Claudia P
Published: September 2024

Microglial cells are highly specialized central nervous system (CNS) cells that can promote the inflammation and neurodegeneration seen in Multiple Sclerosis (MS). MS is a neurodegenerative autoimmune disease characterized by inflammation, demyelination, and axonal degeneration. In MS patients, demyelination is associated with activated microglia. Endothelin-1 (ET-1) is a potent vasoconstrictor that induces severe and prolonged cerebral vasoconstriction and inflammation. However, the mechanism of how ET-1 activates a proinflammatory response in the CNS is unknown. To investigate ET-1’s role in microglia activation, HMC3 cells were treated with ET-1 in the presence or absence of endothelin receptor B antagonist, BQ788. TNFα and IL-6 levels were measured using ELISA. Nitric Oxide (NO) production was measured using Griess Reagent. Reactive oxygen species (ROS) production was measured using the MUSE Oxidative Stress kit. ET-1 increases TNFα levels by 56% (p= 0.0003) and IL-6 levels by 86% (p= 0.0111) in HMC3 cells, and it was decreased to basal levels in the presence of BQ788. NO and ROS production is induced by ET-1 (p<0.05), and treatment with BQ788 was able to decrease them. ET-1 increases STAT-1 activation by 3.5 folds compared to control (p <0.0001) in microglia cells. Moreover, to study ET-1 levels in MS, we used C57BL/6 mice brains with or without induced experimental autoimmune encephalomyelitis (EAE). The brain ET-1 levels were measured by qPCR and ELISA. We found that the ET-1 gene and protein were upregulated by 1.5 folds (p= 0.0199) in EAE mice compared to the control. These data suggest that in vitro administration of ET-1-activated microglia significantly increased inflammatory cytokine levels and NO and ROS formation. This novel mechanism of microglial cell activation will provide key information to understand MS pathogenesis.
Wave and Tidal Energy: A Patent Landscape Study
Authors: Pazhouhan Mohamadreza , Karimi Mazraeshahi Amin , Jahanbakht Mohammad , Rezanejad Kourosh , Rohban Mohammad H.
Published: September 2024

Wave and tidal energy, recognized as vital renewable resources, harness the ocean's kinetic and potential power. This study aims to provide an in-depth patent analysis of the technological landscape within these sectors. We applied a dual approach: first, a descriptive analysis was conducted to explore patent publication trends, technology lifecycle stages, patent activity by country, top assignees, and IPC classifications. Our analysis provided a detailed overview of the sector's growth and the key players involved. Second, we utilized topic modeling, specifically BERTopic enhanced with large language models (LLMs), to identify and fine-tune key technolog-ical themes within the patent data. In this study, we identified seven distinct clusters each for wave and tidal energy using this approach. This method led to a novel categorization of the pa-tents, revealing latent themes within the patent data. Although our categorization differs from traditional methods, it provides deeper insights into the thematic focus of the patents, highlight-ing emerging trends and areas of innovation within wave and tidal energy technologies to better exploit and optimize ocean energy conversion infrastructure.
In Vitro Investigation Using a New Biomechanical Force-Torque Analysis System: Comparison of Conventional and CAD/CAM Fixed Orthodontic Retainers
Authors: Thaden Francesca , Hötzel Linus , Sabbagh Hisham , Mertmann Matthias , Wichelhaus Andrea
Published: September 2024

(1) Background: To further investigate the link between inadvertent tooth movements (ITMs) and mechanical properties of different retainers, the response upon vertical loading was compared in three different retainers (two stainless steel and one nickel-titanium). The influence of different reference teeth was also considered. (2) Methods: Three retainers (R1, R2, R3) were tested in a newly developed biomechanical analysis system (FRANS). They were bonded to 3D-printed models of the lower anterior jaw and vertically displaced up to 0.3mm. Developing forces and moments were recorded at the center of force. (3) Results: The vertical displacement caused vertical forces (Fz) and labiolingual moments (My) to arise. These were highest in the lateral incisors (up to 2.35±0.59N and 9.27±5.86Nmm for R1; 1.69±1.06N and 7.42±2.65Nmm for R2; 3.28±1.73N and 15.91±9.71Nmm for R3) for all analyzed retainers, and with the R3 retainer for all analyzed reference teeth, while the lowest Fz and My values were recorded with the R1 retainer. (4) Conclusions: Displacements of 0.2mm and larger provided forces and moments which could be sufficient to cause unwanted torque movements, such as ITMs in all analyzed retainers. Clinicians must be mindful of these risks and perform posttreatment checkups on patients with retainers of all materials.
Changes in Gut Microbiota in a Peruvian Cattle Genetic Nucleus by Breed and Correlations with Beef Quality
Authors: Quilcate Carlos , Estrada Richard , Romero Yolanda , Rojas Diorman , Mamani Rolando , Hañari-Quispe Renán Dilton , Aliaga Mery , Galindo Walter , Vásquez Héctor V. , Maicelo Jorge L. , Arbizu Carlos I.
Published: September 2024

This study investigates the correlation between gut microbiota diversity and various hematological and meat quality parameters in different cattle breeds, including Angus, Simmental, Braunvieh, Brahman and F1(SMxBR). Using 16S rRNA and 18S rRNA gene sequencing, microbial communities were profiled to discern breed-specific impacts on gut microbiota. Significant correlations were identified between gut microbiota diversity and health parameters, emphasizing the role of microbial diversity in influencing skin condition, fat deposition, and muscle quality. Key bacterial genera such as Blautia, Christensenellaceae_R-7_group, and Coprococcus exhibited significant correlations with meat quality traits. In fungi, genera like Rhodotorula exhibited positive correlations with muscle quality, while protist genera such as Cryptosporidium negatively correlated with meat quality parameters. These findings suggest that host genetics significantly shape the gut microbiota and highlight the potential for targeted microbiota management to optimize gut health, enhance feed efficiency, and improve meat quality in livestock.
Development of STEAM learning media-based on coding scratch game on the material of the characteristics of living things for elementary school
Authors: Qomatfian Livvia Khusnul , Ngazizah Nur , Pangestika Rintis Rizkia
Published: September 2024

This research aims to (1) Produce digital learning media from several STEAM (Science, Technology, Engineering, Art, and Math) disciplines based on scratch in the form of coding games on the material characteristics of living things for elementary schools, and (2) Knowing the feasibility of digital learning media STEAM based on scratch game coding on the material characteristics of living things for elementary schools. The type of research used is Research and Development (R&D) with the ADDIE model (analysis, design, development, implementation, and evaluation). The trial was conducted on 30 students of Muhammadiyah Purworejo University. The sampling technique of this research is purposive random sampling. Data collection used observation, interview, and questionnaire techniques. Data analysis techniques using quantitative descriptive statistical processing. The results of this study, namely: (1) STEAM learning media based on coding scratch games on the material of the characteristics of living things for elementary school. (2) The feasibility of STEAM learning media based on coding scratch games on the material characteristics of living things for elementary schools obtained a value in the aspect of ideas with a percentage of 95.83% very feasible category, the aspect of usefulness with a percentage of 95.00% very feasible category, the aspect of creativity with a percentage of 92.50% very feasible category, and the display aspect with a percentage of 93.33% very feasible category. Based on the results of the assessment of the aspects of ideas, usefulness, creativity, and appearance of STEAM learning media based on coding scratch games on the material of the characteristics of living things for elementary schools, it is declared feasible to apply with very feasible criteria. In addition, digital learning media can harmonize existing technological developments in accordance with the times.
Detection of patiens with pulmonary tuberculosis in the general medical network of the Kabardino-Balkarian republic.
Authors:   The GBUZ «Tuberculosis Dispensary» of the Ministry of Health of the KBR, Samorodov N. A. , Sabanchieva Zh.Kh. ,   Kabardino-Balkarian State University named after H. M. Berbekov, Chudopal S. M. ,   Kabardino-Balkarian State University named after H. M. Berbekov, Deshev A. L. ,   Kabardino-Balkarian State University named after H. M. Berbekov, Kisheva A. A. ,   Kabardino-Balkarian State University named after H. M. Berbekov, Kibisheva A. Y. ,   Kabardino-Balkarian State University named after H. M. Berbekov
Published: September 2024

The population of the Kabardino-Balkarian Republic (KBR) is 903,266 people, the tuberculosis service in this subject is represented by an antitubercular dispensary (PTD) located in the city of Nalchik and tube rooms based on central district hospitals. More than half of the patients registered in the tuberculosis dispensary for pulmonary tuberculosis are examined and treated in the general medical network of the republic before being hospitalized at the dispensary. T h e p u r p o s e o f t h e s t u d y : to analyze the situation in the Kabardino-Balkarian Republic on the diagnosis of tuberculosis in the general medical network. M a t e r i a l s a n d m e t h o d s . Of the examination of 1318 patients with pulmonary tuberculosis from January 2018 to The results December 2022 hospitalized in the health care center of the Kabardino-Balkarian Republic were analyzed. R e s u l t s . When analyzing the results of the examination of tuberculosis patients, it was found that more than half of them (59.9%) received an average of 23.3±6.8 kcal/day inpatient treatment before admission to the dispensary An analysis of the results of the examination of tuberculosis patients found that more than half of them (59.9%) received an average of 23.3±6.8 kcal/day inpatient treatment in the general medical network (OLS) before admission to the dispensary; half of them (46.5%) had bacterial excretion during examination in the PTD. In addition, bacillary patients with pulmonary tuberculosis remained in the OLS for a little longer (26.6±6.9 k/day), which led to a destructive course, as well as an increase in errors in the differential diagnosis of infiltrative pulmonary tuberculosis and community-acquired pneumonia, which reached 30–68%, and the time for diagnosis exceeded 1–3 months. C o n c l u s i o n s . In order to diagnose pulmonary tuberculosis patients as soon as possible and reduce «unjustified» lung operations in tuberculosis patients, the OLS needs the correct organization of the general medical network, namely, to introduce modern methods of etiological diagnosis of tuberculosis, organize a consultation with a phthisiologist or analysis of a specific clinical case at pulmonological commissions before thoracic surgery for unspecified lung disease.
La importancia de la Gestión del Conocimiento en la Sostenibilidad Turística. Estudio de caso en Santiago de Surco-Lima (Perú)
Authors: FRECH HURTADO HELGA CECILIA
Published: September 2024

El estudio resalta la relación que existe entre la gestión del conocimiento y la sostenibilidad turística, teniendo en cuenta que la primera contribuye a generar conocimiento a través de procesos que permiten combinar información y experiencia que posteriormente se aplican a la implementación de estrategias que permitan mejorar la competitividad, la calidad y la mejora continua de los establecimientos y servicios turísticos, así como enfrentar situaciones de riesgo en los destinos. Se tomó el caso del desarrollo de la actividad turística en el distrito de Santiago de Surco (Lima ciudad – Perú), en un contexto de recuperación post pandemia de la COVID-19. Los resultados del análisis mostraron que, si bien el distrito es reconocido por su sostenibilidad ambiental, algunos procesos de gestión del conocimiento ayudarían a consolidar las componentes de carácter sociocultural y económico de este distrito urbano para alcanzar su sostenibilidad turística.
Palabras claves: Gestión del conocimiento, sostenibilidad turística, competitividad, innovación, Lima, Perú.
Geoturismo y patrimonio natural y cultural: aportaciones para la creación de un geoparque en Campo de Cielo (Argentina)
Authors: RAMOS ALDO GUZMÁN
Published: September 2024

Los geoparques, como instrumento de geoconservación y desarrollo socioeconómico se han multiplicado en el mundo en las últimas décadas. Su organización busca integrar estrategias que permitan el uso de los recursos locales sin afectarlos para su aprovechamiento futuro, involucrando a la comunidad local tanto en su preservación como en el usufructo. En este breve ensayo se analizan algunas características y condiciones existentes en el sitio denominado Campo del Cielo, localizado en el noreste de Argentina, el cual fue escenario de una de las mayores lluvias de meteoritos sucedidas en el planeta, dejando un registro natural extraordinario. A eso se suma el vínculo de este fenómeno con las culturas de los pueblos originarios. Este patrimonio natural y cultural debe ser protegido de saqueos y puede revalorizado en el marco del desarrollo del geoturismo. Para lograr esto, una posibilidad es mediante la creación de un geoparque que establezca los fundamentos y permita delinear estrategias a futuro.
Palabras clave: Geoparque; Chaco; Geoturismo; Patrimonio natural; patrimonio cultural. Conservación.
Los mapas de empatía: una herramienta para evaluar las necesidades y motivaciones del turista
Authors: RIVEROS MONTIEL TANIA , LORENA OLMEDO SHIRLEY
Published: September 2024

El estudio busca generar información sobre el perfil del visitante del destino ciudad de Pilar (Paraguay), identificando sus necesidades y motivaciones a través del mapa de empatía. Esta herramienta desarrollada por Dave Gray permite segmentar y diseñar el perfil del turista de acuerdo con sus perspectivas en torno a: pensar - sentir, ver, escuchar, decir-hacer, motivaciones y frustraciones. Se vale de la metodología Design Thinking centrada en las necesidades de la población de estudio. Esta investigación es cualitativa, descriptiva y no experimental. La recolección de datos se realizó mediante encuestas digitales y el muestreo fue no probabilístico. Los datos fueron analizados utilizando métodos estadísticos descriptivos, se realizó la segmentación de participantes por rangos de edad identificándose cinco tipos de turistas y se asignaron nombres ficticios para humanizar el proceso. Para la representación gráfica del mapa de empatía, las respuestas fueron analizadas por cada categoría y reunidas en conceptos claves. Se identifican intereses comunes entre los cinco segmentos. La herramienta facilita una segmentación y diseño del perfil del turista basado en pensamientos, sentimientos, percepciones y comportamientos, promoviendo un destino sostenible y empático. Se recomienda una investigación longitudinal para observar la evolución de las necesidades y motivaciones de los visitantes.
Palabras Claves: mapa, empatía, perfil, turista, turismo; Pilar; Paraguay.
El impacto presupuestario del gasto público en comunicación social del gobierno federal, como instrumento de política fiscal
Authors: Nande Vázquez Edgar Alfredo , Reyes Fong Teodoro , Barajas Palacios Francisco
Published: September 2024

The purpose of social political communication of the Federal Government is to ensure that communication efforts manage to inform the population in a timely and truthful manner about the actions and results of its programs. In this sense, this work aims to demonstrate the budgetary impact generated by spending on communication on the population, in the gross domestic product (GDP) and in electoral periods. In this context, Constitutional Article 134 also establishes that the information disseminated must have an institutional nature, informative and educational purposes, evidencing a positive impact on the population, on economic growth and with a low profile in the elections, complying with the criteria of efficiency, effectiveness, economy, transparency and honesty, respecting the budget ceilings, limits and conditions of the year established by the respective expenditure budgets. The methodology used in this work is supported by the theory of the Political Budget Cycle (PPC), and its data are estimated in panel format, using grouped regression estimators used in econometric works that measure the effects of spending on economic variables.
MHJournal y la Estrategia Europea de Investigación e Innovación 2020/2024, la ruta diamante y ciencia abierta
Authors: Jurado Martín Montserrat
Published: September 2024

Immersed in the digital transformation, MHJournal contributes to the study of artificial intelligence in the research disseminated through its articles, some directly and others as an inevitable approach. We cannot remain on the sidelines of the change that is taking place and that will affect the way we understand current research. In this line, MHJournal is aligned with the European Research and Innovation Strategy 2020/2024.
Imaginarios del feminismo y discurso político: ¿retórica o discurso del odio?
Authors: DÍAZ-BAJO RODRÍGUEZ JAVIER , MARTÍNEZ BORDA RUT , INFANTE PINEDA SARA
Published: September 2024

The proliferation of hostile discourses in the political sphere has increased in recent times as a consequence of a pressing ideological polarization in relation to the social phenomenon of feminism. This work explores the polarized discursive production of the main Spanish political formations on their Instagram accounts, after the application of Organic Law 10/2022 of September 6, comprehensively guaranteeing sexual freedom, known in the media as the law of “only yes is yes”. Through content analysis and critical discourse analysis, the contents that stage social visions of women and feminism are addressed, and that were published by the political parties themselves on their Instagram accounts since 11/01/22. as of 04/30/23. The results obtained allow us to identify how political parties enact intersubjective and imaginary visions of what women and feminism should be, through rhetorically hostile and intolerant speeches. From this point of view, this work aims to stimulate reflection on the productive role that Spanish political parties adopt when inciting hatred through language.
Redes sociales y fútbol en España: el caso de la primera división española
Authors: Herrero Gutiérrez Francisco Javier , Ye Haokeqian
Published: September 2024

En este estudio se examina cuál es el empleo de las redes sociales por parte de los clubes de la Primera División española, tomando como muestra los 20 clubes de la temporada 2022/23. Los objetivos que se plantean son: identificar cuál es el uso de las principales redes sociales, conocer si todos ellos utilizan redes sociales y establecer un ranking del uso de las redes sociales. Para resolver las hipótesis de partida, se utilizará una metodología cuantitativa a partir de una tabla de indicadores creados ad hoc para  este estudio. Se concluye que todos ellos tienen presencia en cuatro o más redes sociales; y entre ellas, al menos todos utilizan Facebook, Twitter e Instagram. Además, otros muchos tienen presencia en variadas redes sociales aunque sin ser homogénea esa utilización (Flickr, LinkedIn, Naver TV, OneFootball, Snapchat, Spotify, TikTok, Twitch, Vine y Weibo). Además, no existe una homogeneidad en los ránkings establecidos.
La comunidad Cosplay y TikTok: una relación singular
Authors: Mora de la Torre Victoria , González Caballero Marta
Published: September 2024

Digital social networks are becoming a great showcase to display very diverse messages. In an easy, fast and accessible way, users can search for content based on their interests. In this research work, twelve international cosplay content creator accounts have been taken on the TikTok application. Using a quantitative and analytical methodology, a total of 8,847 posts made between September 2016 and October 2022 have been analyzed in the different selected tiktokers accounts, with the main objective of delimiting those elements that most favor engagement with the user and establishing their effectiveness. In this way, it has been possible to verify how this type of content creators bet on videos with a short duration -between 12.2 and 17.11 seconds. and a much more concentrated publication strategy in the afternoon and weekend time slots as a bet on their success.
Cryopreserved human alternatively activated macrophages promote resolution of acetaminophen-induced liver injury in mouse
Authors: Candela Maria Elena , Addison Melisande , Aird Rhona , Man Tak Yung , Cartwright Jennifer , Drape Anna , Barnett Mark , Mitchell Donna , McLean Colin , McGowan Neil , Turner Marc , Dear James , Forbes Stuart
Published: September 2024

Acute liver failure (ALF) is a rapidly progressing, life-threatening condition most commonly caused by an overdose of acetaminophen (paracetamol). The antidote, N-acetylcysteine (NAC), has limited efficacy when liver injury is established. If acute liver damage is severe, liver failure can rapidly develop with associated high mortality rates. We have previously demonstrated that alternatively activated macrophages are a potential therapeutic option to reverse acute liver injury in pre-clinical models. In this paper we present data using cryopreserved human alternatively activated macrophages (hAAMs) - which represent a potential, rapidly available, treatment suitable for use in the acute setting. In a mouse model of APAP-induced injury, peripherally injected cryopreserved hAAMs reduced liver necrosis, modulated inflammatory responses, and enhanced liver regeneration. hAAMs were effective even when administered after the therapeutic window for N-acetylcysteine. This cell therapy approach represents a potential treatment for APAP overdose when NAC is ineffective because liver injury is established.