bluuebunny/crossref_metadata_2025 huggingface dataset:
Psychological resistance to insulin therapy in adults with type 2 diabetes: mixed‐method systematic review
Authors: Wang Huey‐Fen , Yeh Mei Chang
Published: November 2011

wang h.‐f. & yeh m.c. (2011) Psychological resistance to insulin therapy in adults with type 2 diabetes: mixed‐method systematic review. Journal of Advanced Nursing 68(4), 743–757.

Aim.  This paper is a report of a review that aimed to describe the phenomenon of psychological resistance to insulin therapy from the perspective of adults with type 2 diabetes mellitus.

Background.  Although the benefits of insulin for people with diabetes who are poorly controlled by oral agents have been established, delay in transition to insulin treatment is common. An understanding of the barriers to insulin from the client’s viewpoint provides information to facilitate appropriate and effective care.

Data sources.  Searches were carried out between 1999 and 2009 using computerized databases, three in English language and one in Chinese.

Review methods.  Review design was a mixed‐method systematic review, and data abstraction and synthesis were undertaken by thematic synthesis. Reviewed articles were restricted to adults with type 2 diabetes and published in English or Chinese.

Results.  Sixteen articles were included. For adults with type 2 diabetes, psychological resistance to insulin therapy could be explained by five themes. Three themes were categorized as cognitive appraisal, including ‘people do not see the necessity for insulin and actively seek ways to control blood sugars without insulin’, ‘people have a holistic view of the consequences of insulin’ and ‘people see insulin therapy as less feasible’. Two themes were categorized as emotional reactions: ‘people see insulin as a source of fear/anxiety’, and ‘the necessity to start insulin therapy has a very negative connotation for them and is associated with dysfunctional emotions’.

Conclusion.  Psychological resistance to insulin therapy can result from a range of personal viewpoints involving cognitive appraisal and/or emotional reactions.
Meningococcal surface fibril (Msf) binds to activated vitronectin and inhibits the terminal complement pathway to increase serum resistance
Authors: Griffiths Natalie J. , Hill Darryl J. , Borodina Elena , Sessions Richard B. , Devos Nathalie I. , Feron Christiane M. , Poolman Jan T. , Virji Mumtaz
Published: November 2011

Complement evasion is an important survival strategy of Neisseria meningitidis (Nm) during colonization and infection. Previously, we have shown that Nm Opc binds to serum vitronectin to inhibit complement‐mediated killing. In this study, we demonstrate meningococcal interactions with vitronectin via a novel adhesin, Msf (meningococcal surface fibril, previously NhhA or Hsf). As with Opc, Msf binds preferentially to activated vitronectin (aVn), engaging at its N‐terminal region but the C‐terminal heparin binding domain may also participate. However, unlike Opc, the latter binding is not heparin‐mediated. By binding to aVn, Msf or Opc can impart serum resistance, which is further increased in coexpressers, a phenomenon dependent on serum aVn concentrations. The survival fitness of aVn‐binding derivatives was evident from mixed population studies, in which msf/opc mutants were preferentially depleted. In addition, using vitronectin peptides to block Msf–aVn interactions, aVn‐induced inhibition of lytic C5b‐9 formation and of serum killing could be reversed. As Msf‐encoding gene is ubiquitous in the meningococcal strains examined and is expressed in vivo, serum resistance via Msf may be of significance to meningococcal pathogenesis. The data imply that vitronectin binding may be an important strategy for the in vivo survival of Nm for which the bacterium has evolved redundant mechanisms.
Administration of Flutamide Alters Sperm Ultrastructure, Sperm Plasma Membrane Integrity and its Stability, and Sperm Mitochondrial Oxidative Capability in the Boar: In Vivo and In Vitro Approach
Authors: Lydka M , Piasecka M , Gaczarzewicz D , Koziorowski M , Bilinska B
Published: November 2011

Contents

Our previous work has shown that an anti‐androgen flutamide administered pre‐ and post‐natally induced adverse effects on the epididymal morphology and function of adult boars. The present investigation is aimed to understand the effect of flutamide and its metabolite on changes in sperm plasma membrane integrity and its stability, changes in mitochondrial oxidative capability and frequency of abnormal sperm. In vivo effects of flutamide (50 mg/kg b.w.) on sperm ultrastructure were examined by electron microscopic observations. In vitro effects of 5, 50 and 100 μg/ml hydroxyflutamide, administered for 2 and 24 h, on sperm plasma membrane integrity were measured by LIVE/DEAD Sperm Vitality kit, while those on sperm membrane stability and mitochondrial oxidoreductive activity were investigated using Merocyanine 540 and NADH tests, respectively. The incidence of abnormal spermatozoa increased significantly (p < 0.05) in flutamide‐treated boars compared with controls. In an in vitro approach, low dose of hydroxyflutamide in 2‐h incubations appeared less effective in altering the sperm plasma membrane integrity and its stability than two higher doses used (p < 0.05). No further decrease in the membrane integrity was found when the effect of anti‐androgen lasted for 24 h. On the other hand, a decrease in sperm membrane destabilization and mitochondrial oxidoreductive activity was strengthened after 24 h of hydroxyflutamide administration (p < 0.05). Characterization of sperm parameters with regard to oxidative capability of mitochondria, plasma membrane changes and sperm ultrastructure provides novel data on the boar sperm sensitivity to anti‐androgen action. Results indicate high sensitivity of boar spermatozoa to androgen withdrawal.
Relationship Between Dose of Cloprostenol and Age of Corpus Luteum on the Luteolytic Response of Early Dioestrous Mares: A Field Study
Authors: Cuervo‐Arango J , Newcombe JR
Published: November 2011

Contents

The objective of this study was to establish and characterize the relationship between the dose of cloprostenol (37.5, 250, 500 and 750 μg) and the age of the early corpus luteum (CL) (80, 88, 96, 104 and 112 h) on the luteolytic response of mares. Behavioural oestrus and ultrasonographic signs of return to oestrus were considered as the occurrence of full luteolysis. A total of 298 mares were divided into groups according to dose of cloprostenol and CL age. There was an effect of dose of cloprostenol (p < 0.001) and age of the CL at the time of treatment (p < 0.001) on the percentage of mares with full luteolysis. The efficacy of 37.5 μg of d‐cloprostenol was similar to that of 250  μg of d,l‐cloprostenol (p  >  0.05); and that of 500 similar to that of 750 μg (p > 0.05). The higher dose groups (500 and 750 μg) induced full luteolysis more frequently than the lower dose groups (37.5 and 250 μg) 96–104 h post‐ovulation. There was no effect of CL age or cloprostenol dose on the interovulatory interval (p > 0.05). In conclusion, the effect of cloprostenol on the percentage of mares undergoing full luteolysis is dose‐dependent. However, this effect is only evident in mares with CLs aged between 96 and 104 h. There is no advantage of administering more than 500 μg of d,l‐cloprostenol (Estrumate®), to obtain a higher percentage of mares with full luteolysis in mares with CLs aged 80–112 h.
JUA clinical guidelines for benign prostatic hyperplasia
Authors: Homma Yukio , Gotoh Momokazu , Yokoyama Osamu , Masumori Naoya , Kawauchi Akihiro , Yamanishi Tomonori , Ishizuka Osamu , Seki Narihito , Kamoto Toshiyuki , Nagai Atsushi , Ozono Seiichiro
Published: November 2011

The Japanese Urological Association has developed Clinical Guidelines for Benign Prostatic Hyperplasia (BPH) for men with suspected BPH. This article is an English translation of the abridged version of the Guidelines. The Guidelines were formulated on the basis of evidence retrieved from the PubMed database between 1995 and 2009, as well as other relevant sources. The target patients of these Guidelines are men with suspected BPH, and the target users are urologists. A mandatory assessment should include a medical history, a physical examination, the completion of symptom and quality of life questionnaires, a urinalysis, a prostate ultrasonography, measurement of serum prostate specific antigen and postvoid residual urine, and uroflowmetry. Optional tests include keeping a bladder diary, the measurement of serum creatinine, and upper urinary tract ultrasonography. Care should be taken to not overlook coexisting diseases such as infections or malignancies that may obscure the diagnosis. Treatment should consist of conservative therapy or the use of medications such as α1‐adrenoceptor antagonists, or both. The use of 5α‐reductase inhibitors or anticholinergic agents should be considered in patients with an enlarged prostate (>30 mL) or overactive bladder symptoms (Overactive Bladder Symptom Score ≥6), respectively. Surgical intervention is indicated when non‐surgical treatments fail to provide sufficient symptomatic relief, and when bladder outlet obstruction is highly suspected.
Inhibition of cortactin and SIRT1 expression attenuates migration and invasion of prostate cancer DU145 cells
Authors: Nakane Keita , Fujita Yasunori , Terazawa Riyako , Atsumi Yuko , Kato Taku , Nozawa Yoshinori , Deguchi Takashi , Ito Masafumi
Published: November 2011

Objectives:  Cortactin is overexpressed in various types of cancer and enhances cell motility. It has been recently reported that silent mating type information regulation 2 homolog 1 interacts with cortactin and promotes cell migration. Here, we examined the role of cortactin and silent mating type information regulation 2 homolog 1 in migration and invasion of prostate cancer cells.

Methods:  The cortactin expression levels in DU145, LNCaP and PC3 prostate cancer cells, and in PrEC normal human prostate epithelial cells were evaluated by western blot analysis. In DU145 cells, the expression of cortactin or silent mating type information regulation 2 homolog 1 was inhibited by small interfering RNA, and the effects of their knockdown on migration and invasion were examined by cell migration and invasion assays. To determine the localization of cortactin and silent mating type information regulation 2 homolog 1, western blot and immunofluorescence microscopic analyses were carried out. The functional interaction between silent mating type information regulation 2 homolog 1 and cortactin was also studied by in vivo acetylation assay.

Results:  The protein expression of cortactin was significantly higher in DU145 cells than in other cell lines. Knockdown of cortactin or silent mating type information regulation 2 homolog 1 expression inhibited both migration and invasion of DU145 cells. Similarly to cortactin, silent mating type information regulation 2 homolog 1 was found to be predominantly expressed in the cytoplasm. Finally, the knockdown of silent mating type information regulation 2 homolog 1 expression increased the acetylation level of cortactin.

Conclusions:  Our findings suggest that inhibition of cortactin or silent mating type information regulation 2 homolog 1 expression attenuates migration and invasion of DU145 cells and this could represent a promising strategy to regulate metastasis of prostate cancer.
RepSnapping: Efficient Image Cutout for Repeated Scene Elements
Authors: Huang Hua , Zhang Lei , Zhang Hong‐Chao
Published: November 2011

Repeated scene elements are copious and ubiquitous in natural images. Cutout of those repeated elements usually involves tedious and laborious user interaction by previous image segmentation methods. In this paper, we present RepSnapping, a novel method oriented to cutout of repeated scene elements with much less user interaction. By exploring inherent similarity between repeated elements, a new optimization model is introduced to thread correlated elements in the segmentation procedure. The model proposed here enables efficient solution using max‐flow/min cut on an extended graph. Experiments indicate that RepSnapping facilitates cutout of repeated elements better than the state‐of‐the‐art interactive image segmentation and repetition detection methods.
Efficient opacity specification based on feature visibilities in direct volume rendering
Authors: Wang Yunhai , Zhang Jian , Chen Wei , Zhang Huai , Chi Xuebin
Published: November 2011

Due to 3D occlusion, the specification of proper opacities in direct volume rendering is a time‐consuming and unintuitive process. The visibility histograms introduced by Correa and Ma reflect the effect of occlusion by measuring the influence of each sample in the histogram to the rendered image. However, the visibility is defined on individual samples, while volume exploration focuses on conveying the spatial relationships between features. Moreover, the high computational cost and large memory requirement limits its application in multi‐dimensional transfer function design.

In this paper, we extend visibility histograms to feature visibility, which measures the contribution of each feature in the rendered image. Compared to visibility histograms, it has two distinctive advantages for opacity specification. First, the user can directly specify the visibilities for features and the opacities are automatically generated using an optimization algorithm. Second, its calculation requires only one rendering pass with no additional memory requirement. This feature visibility based opacity specification is fast and compatible with all types of transfer function design. Furthermore, we introduce a two‐step volume exploration scheme, in which an automatic optimization is first performed to provide a clear illustration of the spatial relationship and then the user adjusts the visibilities directly to achieve the desired feature enhancement. The effectiveness of this scheme is demonstrated by experimental results on several volumetric datasets.
Discriminative Sketch‐based 3D Model Retrieval via Robust Shape Matching
Authors: Shao Tianjia , Xu Weiwei , Yin Kangkang , Wang Jingdong , Zhou Kun , Guo Baining
Published: November 2011

We propose a sketch‐based 3D shape retrieval system that is substantially more discriminative and robust than existing systems, especially for complex models. The power of our system comes from a combination of a contour‐based 2D shape representation and a robust sampling‐based shape matching scheme. They are defined over discriminative local features and applicable for partial sketches; robust to noise and distortions in hand drawings; and consistent when strokes are added progressively. Our robust shape matching, however, requires dense sampling and registration and incurs a high computational cost. We thus devise critical acceleration methods to achieve interactive performance: precomputing kNN graphs that record transformations between neighboring contour images and enable fast online shape alignment; pruning sampling and shape registration strategically and hierarchically; and parallelizing shape matching on multi‐core platforms or GPUs. We demonstrate the effectiveness of our system through various experiments, comparisons, and user studies.
Flexible Splicing of Upper‐Body Motion Spaces on Locomotion
Authors: van Basten B.J.H. , Egges A.
Published: November 2011

This paper presents an efficient technique for synthesizing motions by stitching, or splicing, an upper‐body motion retrieved from a motion space on top of an existing lower‐body locomotion of another motion. Compared to the standard motion splicing problem, motion space splicing imposes new challenges as both the upper and lower body motions might not be known in advance.

Our technique is the first motion (space) splicing technique that propagates temporal and spatial properties of the lower‐body locomotion to the newly generated upper‐body motion and vice versa. Whereas existing techniques only adapt the upper‐body motion to fit the lower‐body motion, our technique also adapts the lower‐body locomotion based on the upper body task for a more coherent full‐body motion. In this paper, we will show that our decoupled approach is able to generate high‐fidelity full‐body motion for interactive applications such as games.
River Networks for Instant Procedural Planets
Authors: Derzapf E. , Ganster B. , Guthe M. , Klein R.
Published: November 2011

Realistic terrain models are required in many applications, especially in computer games. Commonly, procedural models are applied to generate the corresponding models and let users experience a wide variety of new environments. Existing algorithms generate landscapes immediately with view‐dependent resolution and without preprocessing. Unfortunately, landscapes generated by such algorithms lack river networks and therefore appear unnatural. Algorithms that integrate realistic river networks are computationally expensive and cannot be used to generate a locally adaptive high resolution landscape during a fly‐through. In this paper, we propose a novel algorithm to generate realistic river networks. Our procedural algorithm creates complete planets and landscapes with realistic river networks within seconds. It starts with a coarse base geometry of a planet without further preprocessing and user intervention. By exploiting current graphics hardware, the proposed algorithm is able to generate adaptively refined landscape geometry during fly‐throughs.
Edge‐Optimized À‐Trous Wavelets for Local Contrast Enhancement with Robust Denoising
Authors: Hanika Johannes , Dammertz Holger , Lensch Hendrik
Published: November 2011

In this paper we extend the edge‐avoiding à‐trous wavelet transform for local contrast enhancement while avoiding common artifacts such as halos and gradient reversals. We show that this algorithm is a highly efficient and robust tool for image manipulation based on multi‐scale decompositions. It can achieve comparable results to previous high‐quality methods while being orders of magnitude faster and simpler to implement. Our method is much more robust than previously known fast methods by avoiding aliasing and ringing which is achieved by introducing a data‐adaptive edge weight. Operating on multi‐scale, our algorithm can directly include the BayesShrink method for denoising. For moderate noise levels our edge‐optimized technique consistently improves separation of signal and noise.
Computing 3D Shape Guarding and Star Decomposition
Authors: Yu W. , Li X.
Published: November 2011

This paper proposes an effective framework to compute the visibility guarding and star decomposition of 3D solid shapes. We propose a progressive integer linear programming algorithm to solve the guarding points that can visibility cover the entire shape; we also develop a constrained region growing scheme seeded on these guarding points to get the star decomposition. We demonstrate this guarding/decomposition framework can benefit graphics tasks such as shape interpolation and shape matching/retrieval.
Motion Deblurring from a Single Image using Circular Sensor Motion
Authors: Bando Yosuke , Chen Bing‐Yu , Nishita Tomoyuki
Published: November 2011

Image blur caused by object motion attenuates high frequency content of images, making post‐capture deblurring an ill‐posed problem. The recoverable frequency band quickly becomes narrower for faster object motion as high frequencies are severely attenuated and virtually lost. This paper proposes to translate a camera sensor circularly about the optical axis during exposure, so that high frequencies can be preserved for a wide range of in‐plane linear object motion in any direction within some predetermined speed. That is, although no object may be photographed sharply at capture time, differently moving objects captured in a single image can be deconvolved with similar quality. In addition, circular sensor motion is shown to facilitate blur estimation thanks to distinct frequency zero patterns of the resulting motion blur point‐spread functions. An analysis of the frequency characteristics of circular sensor motion in relation to linear object motion is presented, along with deconvolution results for photographs captured with a prototype camera.
SSD: Smooth Signed Distance Surface Reconstruction
Authors: Calakli F. , Taubin G.
Published: November 2011

We introduce a new variational formulation for the problem of reconstructing a watertight surface defined by an implicit equation, from a finite set of oriented points; a problem which has attracted a lot of attention for more than two decades. As in the Poisson Surface Reconstruction approach, discretizations of the continuous formulation reduce to the solution of sparse linear systems of equations. But rather than forcing the implicit function to approximate the indicator function of the volume bounded by the implicit surface, in our formulation the implicit function is forced to be a smooth approximation of the signed distance function to the surface. Since an indicator function is discontinuous, its gradient does not exist exactly where it needs to be compared with the normal vector data. The smooth signed distance has approximate unit slope in the neighborhood of the data points. As a result, the normal vector data can be incorporated directly into the energy function without implicit function smoothing. In addition, rather than first extending the oriented points to a vector field within the bounding volume, and then approximating the vector field by a gradient field in the least squares sense, here the vector field is constrained to be the gradient of the implicit function, and a single variational problem is solved directly in one step. The formulation allows for a number of different efficient discretizations, reduces to a finite least squares problem for all linearly parameterized families of functions, and does not require boundary conditions. The resulting algorithms are significantly simpler and easier to implement, and produce results of quality comparable with state‐of‐the‐art algorithms. An efficient implementation based on a primal‐graph octree‐based hybrid finite element‐finite difference discretization, and the Dual Marching Cubes isosurface extraction algorithm, is shown to produce high quality crack‐free adaptive manifold polygon meshes.
Real Time Edit Propagation by Efficient Sampling
Authors: Bie Xiaohui , Huang Haoda , Wang Wencheng
Published: November 2011

It is popular to edit the appearance of images using strokes, owing to their ease of use and convenience of conveying the user's intention. However, propagating the user inputs to the rest of the images requires solving an enormous optimization problem, which is very time consuming, thus preventing its practical use. In this paper, a two‐step edit propagation scheme is proposed, first to solve edits on clusters of similar pixels and then to interpolate individual pixel edits from cluster edits. The key in our scheme is that we use efficient stroke sampling to compute the affinity between image pixels and strokes. Based on this, our clustering does not need to be stroke‐adaptive and thus the number of clusters is greatly reduced, resulting in a significant speedup. The proposed method has been tested on various images, and the results show that it is more than one order of magnitude faster than existing methods, while still achieving precise results compared with the ground truth. Moreover, its efficiency is not sensitive to the number of strokes, making it suitable for performing dense edits in practice.
REMOVING THE CULTURAL AND MANAGERIAL BARRIERS IN PROJECT‐TO‐PROJECT LEARNING: A CASE FROM THE UK PUBLIC SECTOR
Authors: HALL MARK , KUTSCH ELMAR , PARTINGTON DAVID
Published: November 2011

Project‐based initiatives form a major part of government investment and, so, learning from past projects should be a major concern for public sector organizations. Previous research has explored systems and processes for project‐based learning but little research has examined the social and cultural factors that enable this learning to be applied with useful effect. This paper reports on two successive major UK government projects. The introduction of independent learning accounts (ILAs) and the subsequent introduction of educational maintenance allowances (EMAs) following the scrapping of the former. Although similar in many respects, the first was a major failure while the second, having learned the lessons of the first, was acclaimed as a success. Using a cultural analysis, this case study shows how project‐to‐project learning enabled the EMA project team to learn from the failed project. This resulted in two significant changes in government and civil service organizational culture.
Remedying the Inequalities of Economic Citizenship in Europe: Cohesion Policy and the Negative Right to Move
Authors: Strumia Francesca
Published: November 2011

European supranational citizenship draws the boundaries of a community of citizens, sharing the status of economic actors in the single market. The specter of inequality threatens however the resulting promise of shared membership: economic citizens face profoundly different opportunities for economic involvement, depending on their nationality and residence within the Union. Free movement rights open up a narrow way out of inequality by enabling European citizens to relocate; however, they cannot alone solve the inequality problem that economic citizenship poses. In the quest for alternative remedies to this problem, this article explores the potential of European cohesion policy. It argues that cohesion policy, by addressing gaps in wealth throughout the Community, draws the traits of a negative right to move, which adds to the protection of European economic citizenship. Through the cohesion lens, the premises are laid for a renewed assessment of the project of shared economic citizenship.
Bosman—There and Back Again: The Legitimacy of Playing Quotas under European Union Sports Policy
Authors: Gardiner Simon , Welch Roger
Published: November 2011

The 1995 ruling of the European Court of Justice in Bosman was a pivotal point in the relationship between the European Union and sport. It has had an immense impact upon professional team sports, most notably football, in terms of liberalising the transfer system and abolishing player quotas. This paper will chart the development of a European sports law policy generally and will specifically discuss two current proposals concerning the reintroduction of playing quotas in football. We will examine the legality of these proposals with reference to Article 45 of the Treaty on the Functioning of the European Union and will evaluate the political context within which these proposals have been promulgated. It will be suggested that a possible solution, which should end legal uncertainty, could be the adoption of a collective agreement or directive based on the methodology of reflexive labour law.
Emergence of an HIV‐1 cluster harbouring the major protease L90M mutation among treatment‐naïve patients in Tel Aviv, Israel
Authors: Turner D , Amit S , Chalom S , Penn O , Pupko T , Katchman E , Matus N , Tellio H , Katzir M , Avidor B
Published: November 2011

Objective

Drug resistance‐associated mutations (DRMs) among HIV‐1 treatment‐naïve patients have increased in recent years. Their incidence and prevalence in various exposure risk categories (ERCs) were evaluated.

Design

Plasma samples of HIV‐1 treatment‐naïve patients diagnosed between 2001 and 2009 at the Tel Aviv Medical Center were screened for DRMs.

Methods

Samples obtained from patients following the HIV diagnosis were analysed retrospectively. Genotyping was carried out using the Trugene HIV‐1 genotype kit (Siemens, Berkeley, CA, USA). Phylogenetic relationships among viral sequences were estimated using the maximum likelihood method.

Results

Thirty‐eight of the 266 analysed sequences (14.3%) had DRMs, all occurring exclusively in the group of men who have sex with men (MSM). The rate of DRMs has constantly risen, reaching a peak of 21.9% in 2009. Notably, protease inhibitor (PI) DRMs became the most frequent DRMs in 2009. Phylogenetic analysis showed a tight cluster comprising 13 of 14 viruses harbouring the L90M major PI resistance mutation, suggesting a single infection source.

Conclusion

There was an unexpectedly high rate of the major L90M PI resistance mutation in the MSM group. The clustered transmission of this mutation might be related to a high‐risk sexual behaviour. Added to nonnucleoside reverse transcriptase inhibitor and nucleoside reverse transcriptase inhibitor resistance mutations, such a PI mutation may limit future therapeutic options for this particular patient population.
Diabetes and previous stroke: hazards for intravenous thrombolysis?
Authors: Fuentes B. , Martínez‐Sánchez P. , Alonso de Leciñana M. , Simal P. , Reig G. , Díaz‐Otero F. , Masjuán J. , Egido J. , Vivancos J. , Gil‐Nuñez A. , Díez‐Tejedor E. ,   on behalf of the Madrid Stroke Network
Published: November 2011

Background and purpose:  Alteplase licensing approval in Europe does not advocate intravenous thrombolysis (IVT) for diabetic ischaemic stroke (IS) patients with previous cerebral infarction (PCI). Our aim was to assess whether concomitant diabetes mellitus (DM) and PCI are associated with symptomatic intracerebral haemorrhage (SICH) and poor outcome after IVT.

Methods:  Multicentre prospective registry, which included consecutive IVT‐treated, acute IS patients from January 2003 to December 2010. The frequency of SICH (SITS‐MOST criteria) and 3‐month outcomes (mRS) were compared between the following groups: (i) diabetic patients with PCI (DM+/PCI+); (ii) diabetic patients without PCI (DM+/PCI−); (iii) non‐diabetic patients with PCI (DM−/PCI+); and (iv) patients without diabetes or PCI (DM−/PCI−).

Results:  A total of 1475 patients were included. Thirty‐four patients (2.3%) had known DM and PCI, 258 (17.5%) were diabetics without PCI, and 119 (8.1%) had a PCI and no DM. Thirty‐six patients (2.6%) developed SICH, with no differences between groups (P = 985). Fifteen (40.9%) DM+/PCI+ patients, 113 (46.5%) DM+/PCI− patients, 47 (42%) DM−/PCI+ patients and 414 (40.9%) DM−/PCI− patients had mRS ≥ 3 at 3 months (P = 427). The presence neither of DM nor of PCI, nor their combination, had any impact on the risk of SICH or on outcome at 3 months after adjusting for age, stroke severity and glucose levels on admission.

Conclusions:  Acute IS diabetic patients with PCI who were treated with IVT had similar outcomes to patients without such history, with no increase in the rates of SICH. Thus, they should not be excluded from IVT only on the basis of DM and PCI.
Mapping the Field of UK–EU Policing*
Authors: BERENSKOETTER FELIX
Published: November 2011

This article seeks to improve understanding of the field of policing in an evolving European space. It explores connections between officers working in police institutions affiliated with the European Union and police institutions in the United Kingdom. Its main contribution lies in offering a typology of interactions surrounding the exchange and interpretation of information through (i) shared databases, (ii) liaison officers, (iii) training programmes and (iv) transfer of threat images. This allows sketching a more nuanced picture of the field of EU–UK policing in terms of both its internal composition and its external boundaries.
Carpal kinematics in quadrupedal monkeys: towards a better understanding of wrist morphology and function
Authors: Daver Guillaume , Berillon Gilles , Grimaud‐Hervé Dominique
Published: November 2011

The purpose of this study is to provide new data on carpal kinematics in primates in order to deepen our understanding of the relationships between wrist morphology and function. To that end, we provide preliminary data on carpal kinematics in seven species of quadrupedal monkeys that have not been previously investigated in this regard (cercopithecoids, n = 4; ceboids, n = 3). We radiographed wrists from cadavers at their maximum radial and ulnar deviations, as well as at maximum flexion and extension. We took angular measurements to quantify the contribution of the mobility of the two main wrist joints (antebrachiocarpal and midcarpal) with respect to total wrist mobility. We also recorded qualitative observations. Our quantitative results show few clear differences among quadrupedal monkeys for radioulnar deviation and flexion–extension: all the primates studied exhibit a greater midcarpal mobility (approximately 54–83% of the total range of motion) than antebrachiocarpal mobility; however, we identified two patterns of carpal kinematics that show the functional impact of previously recognised morphological variations in quadrupedal monkeys. Firstly, qualitative results show that the partition that divides the proximal joint of the wrist in ceboids results in less mobility and more stability of the ulnar part of the wrist than is seen in cercopithecoids. Secondly, we show that the olive baboon specimen (Papio anubis) is characterised by limited antebrachiocarpal mobility for extension; this effect is likely the result of a radial process that projects on the scaphoid notch, as well as an intraarticular meniscus. Because of these close relationships between carpal kinematics and morphology in quadrupedal monkeys, we hypothesise that, to some extent, these functional tendencies are related to their locomotor hand postures.
On the resistance to extinction of fear conditioned to angry faces
Authors: Rowles Monique E. , Lipp Ottmar V. , Mallan Kimberley M.
Published: November 2011

The present study investigated whether, like fear conditioned to pictures of snakes and spiders, fear conditioned to angry faces resists extinction even after verbal instruction and removal of the shock electrode. Participants were trained in a differential Pavlovian fear conditioning procedure with angry face or happy face conditional stimuli (CSs). Prior to extinction, half the participants in each group were informed that no more unconditional stimuli would be presented and the shock electrode was removed. In the absence of this manipulation, participants showed resistance to extinction after training with angry face CSs, but not after training with happy face CSs. Instructed extinction and electrode removal abolished fear conditioning regardless of the emotion expressed by the CS faces. This finding suggests that fear conditioned to angry faces, like fear conditioned to racial out‐group faces, is more malleable than fear conditioned to snakes and spiders.
The feedback‐related negativity (FRN) in adolescents
Authors: Zottoli Tina M. , Grose‐Fifer Jillian
Published: November 2011

This study examined age‐related differences in the ERP correlates of external feedback processing (i.e., the feedback‐related negativity [FRN]) in adolescent and young adult males, using a simple gambling task involving unpredictable monetary losses and gains of low and high magnitude. The FRN was larger after losses than gains, and was modulated by the magnitude of gains, but not the magnitude of losses, for all participants regardless of age. FRN amplitude was larger in adolescents than adults and also discriminated relatively less strongly between gains and losses in adolescents. In addition, the morphology of the waveform after high losses suggests that feedback in this condition may have been processed less efficiently by adolescents. Our results suggest that, although the FRN in adults and adolescents share some common characteristics, the neural processes that generate the FRN are still developing in midadolescence. These findings are discussed in the context of adolescent risk taking.
Inhibition of exocytosis or endocytosis blocks activity‐dependent redistribution of synapsin
Authors: Orenbuch Ayelet , Shulman Yoav , Lipstein Noa , Bechar Amit , Lavy Yotam , Brumer Eliaz , Vasileva Mariya , Kahn Joy , Barki‐Harrington Liza , Kuner Thomas , Gitler Daniel
Published: November 2011

J. Neurochem. (2012) 120, 248–258.

The synaptic vesicle cycle encompasses the pre‐synaptic events that drive neurotransmission. Influx of calcium leads to the fusion of synaptic vesicles with the plasma membrane and the release of neurotransmitter, closely followed by endocytosis. Vacated release sites are repopulated with vesicles which are then primed for release. When activity is intense, reserve vesicles may be mobilized to counteract an eventual decline in transmission. Recently, interplay between endocytosis and repopulation of the readily releasable pool of vesicles has been identified. In this study, we show that exo‐endocytosis is necessary to enable detachment of synapsin from reserve pool vesicles during synaptic activity. We report that blockage of exocytosis in cultured mouse hippocampal neurons, either by tetanus toxin or by the deletion of munc13, inhibits the activity‐dependent redistribution of synapsin from the pre‐synaptic terminal into the axon. Likewise, perturbation of endocytosis with dynasore or by a dynamin dominant‐negative mutant fully prevents synapsin redistribution. Such inhibition of synapsin redistribution occurred despite the efficient phosphorylation of synapsin at its protein kinase A/CaMKI site, indicating that disengagement of synapsin from the vesicles requires exocytosis and endocytosis in addition to phosphorylation. Our results therefore reveal hitherto unidentified feedback within the synaptic vesicle cycle involving the synapsin‐managed reserve pool.
Microbes and mass extinctions: paleoenvironmental distribution of microbialites during times of biotic crisis
Authors: MATA S. A. , BOTTJER D. J.
Published: November 2011

Widespread development of microbialites characterizes the substrate and ecological response during the aftermath of two of the ‘big five’ mass extinctions of the Phanerozoic. This study reviews the microbial response recorded by macroscopic microbial structures to these events to examine how extinction mechanism may be linked to the style of microbialite development. Two main styles of response are recognized: (i) the expansion of microbialites into environments not previously occupied during the pre‐extinction interval and (ii) increases in microbialite abundance and attainment of ecological dominance within environments occupied prior to the extinction. The Late Devonian biotic crisis contributed toward the decimation of platform margin reef taxa and was followed by increases in microbialite abundance in Famennian and earliest Carboniferous platform interior, margin, and slope settings. The end‐Permian event records the suppression of infaunal activity and an elimination of metazoan‐dominated reefs. The aftermath of this mass extinction is characterized by the expansion of microbialites into new environments including offshore and nearshore ramp, platform interior, and slope settings. The mass extinctions at the end of the Triassic and Cretaceous have not yet been associated with a macroscopic microbial response, although one has been suggested for the end‐Ordovician event. The case for microbialites behaving as ‘disaster forms’ in the aftermath of mass extinctions accurately describes the response following the Late Devonian and end‐Permian events, and this may be because each is marked by the reduction of reef communities in addition to a suppression of bioturbation related to the development of shallow‐water anoxia.
Terminal Hematuria Associated with Oral Isotretinoin Treatment in a Patient with Acne Vulgaris
Authors: Sarifakioglu Evren , Yilmaz Ayse E. , Erpolat Seval
Published: November 2011

Abstract:  Hematuria is defined as the abnormal presence of red blood cells in the urine and is commonly divided into gross and microscopic hematuria. Terminal hematuria occurs at the end of the urine stream and may have a prostatic, bladder, or trigonal cause. Here, we present a 16‐year‐old boy who developed terminal hematuria after 1 month of treatment with isotretinoin for acne vulgaris. This side effect of isotretinoin is not reported in the literature. This is the first case report.
Segmental Becker’s Nevi with Mucosal Involvement
Authors: Pahwa Pooja , Sethuraman Gomathy
Published: November 2011

Abstract:  Becker’s nevus otherwise known as Becker’s pigmented hairy nevus, is a common melanotic epidermal hypermelanosis. It usually presents as a large unilateral patch of hyperpigmentation and hypertrichosis on the shoulder, chest, or back of an adult man. It can be bilateral or multiple and affect areas other than the usual sites. We report a 16‐year‐old boy with two Becker’s nevi on the left side of the face in a segmental distribution with extension onto the oral mucosa. This case is being reported for its rare presentation.
CULTURE CONDITIONS INFLUENCE THE GROWTH DYNAMICS AND THE PRODUCTION OF COCCONEIS SCUTELLUM (BACILLARIOPHYTA)1
Authors: Zupo Valerio , Patalano Carmela , Messina Patrizia
Published: November 2011

The optimal conditions for the growth of two conspecific benthic diatoms were defined through factorial experimentation. We investigated the roles of light spectrum, nutrient availability, and culture conditions on the laboratory production of Cocconeis scutellum scutellum Ehrenb. and C. scutellum parva Grunow. Diatoms were cultivated in petri dishes, and inverted optical microscopy was used to periodically record their abundance. Growth curves were constructed from these data for each culture condition. In addition, at the end of the experiment we performed weight measurements to determine the total production for each of the considered conditions. We found that cultivation in nonsealed (NS) petri dishes (permitting gas exchange) represented the most productive technique. Cell density and biomass varied among light spectra, although this effect was inconsistent. For example, the Sylvania Gro‐Lux lamp (GL) produced the lowest cell density but highest biomass, suggesting that it may promote the production of larger cells. Surprisingly, of the culture media tested, f/2 (a media commonly used for the culture of diatoms) was the least productive. Diatom density and biomass were variably dependent on the combination of experimental culture conditions and strain used. These physical and chemical factors act mainly on given features of the diatom growth curve. These results permitted us to devise adequate culture protocols, to produce a biotechnologically important substance: a proapoptotic compound that specifically destroys the androgenic gland of a shrimp and could find novel applications in human medicine.
EFFECT OF ELEVATED TEMPERATURE, DARKNESS, AND HYDROGEN PEROXIDE TREATMENT ON OXIDATIVE STRESS AND CELL DEATH IN THE BLOOM‐FORMING TOXIC CYANOBACTERIUM MICROCYSTIS AERUGINOSA1
Authors: Bouchard Josée N. , Purdie Duncan A.
Published: November 2011

This study assessed the implication of oxidative stress in the mortality of cells of Microcystis aeruginosa Kütz. Cultures grown at 25°C were exposed to 32°C, darkness, and hydrogen peroxide (0.5 mM) for 96 h. The cellular abundance, chl a concentration and content, maximum photochemical efficiency of PSII (Fv/Fm ratio), intracellular oxidative stress (determined with dihydrorhodamine 123 [DHR]), cell mortality (revealed by SYTOX‐labeling of DNA), and activation of caspase 3–like proteins were assessed every 24 h. The presence of DNA degradation in cells of M. aeruginosa was also assessed using a terminal deoxynucletidyl transferase‐mediated dUTP nick end labeling (TUNEL) assay at 96 h. Transferring cultures from 25°C to 32°C was generally beneficial to the cells. The cellular abundance and chl a concentration increased, and the mortality remained low (except for a transient burst at 72 h) as did the oxidative stress. In darkness, cells did not divide, and the Fv/Fm continuously decreased with time. The slow increase in intracellular oxidative stress coincided with the activation of caspase 3–like proteins and a 15% and 17% increase in mortality and TUNEL‐positive cells, respectively. Exposure to hydrogen peroxide had the most detrimental effect on cells as growth ceased and the Fv/Fm declined to near zero in less than 24 h. The 2‐fold increase in oxidative stress matched the activation of caspase 3–like proteins and a 40% and 37% increase in mortality and TUNEL‐positive cells, respectively. These results demonstrate the implication of oxidative stress in the stress response and mortality of M. aeruginosa.
A UNIQUE PSEUDANABAENALEAN (CYANOBACTERIA) GENUS NODOSILINEA GEN. NOV. BASED ON MORPHOLOGICAL AND MOLECULAR DATA1
Authors: Perkerson III Ralph B. , Johansen Jeffrey R. , Kovácik Lubomir , Brand Jerry , Kaštovský Jan , Casamatta Dale A.
Published: November 2011

The cyanobacteria are a diverse, ancient lineage of oxygenic, phototrophic bacteria. Ubiquitous in nearly all ecosystems, the alpha‐level diversity of these organisms lags behind other algal lineages due to a perceived dearth of phylogenetically useful characters. Recent phylogenetic studies of species within the genus Leptolyngbya have demonstrated that this is a polyphyletic assemblage. One group of strains that fits within the current circumscription of Leptolyngbya is genetically and phylogenetically distinct from Leptolyngbya sensu stricto. Members of this clade possess both a morphological synapomorphy and shared 16S‐23S internal transcribed spacer (ITS) secondary structure, allowing the diagnosis of the new cyanobacterial genus Nodosilinea. Members of this genus are united by the unique ability to form nodules along the length of the filament. This trait has been previously observed only in the species Leptolyngbya nodulosa Z. Li et J. Brand, and we have chosen this species as the generitype of Nodosilinea. We currently recognize four species in the genus, N. nodulosa (Z. Li et J. Brand) comb. nov., N. bijugata (Kong.) comb. nov., N. conica sp. nov., and N. epilithica sp. nov.
INTERACTIVE EFFECTS OF IRRADIANCE AND CO2 ON CO2 FIXATION AND N2 FIXATION IN THE DIAZOTROPH TRICHODESMIUM ERYTHRAEUM (CYANOBACTERIA)1
Authors: Garcia Nathan S. , Fu Fei‐Xue , Breene Cynthia L. , Bernhardt Peter W. , Mulholland Margaret R. , Sohm Jill A. , Hutchins David A.
Published: November 2011

The diazotrophic cyanobacteria Trichodesmium spp. contribute approximately half of the known marine dinitrogen (N2) fixation. Rapidly changing environmental factors such as the rising atmospheric partial pressure of carbon dioxide (pCO2) and shallower mixed layers (higher light intensities) are likely to affect N2‐fixation rates in the future ocean. Several studies have documented that N2 fixation in laboratory cultures of T. erythraeum increased when pCO2 was doubled from present‐day atmospheric concentrations (∼380 ppm) to projected future levels (∼750 ppm). We examined the interactive effects of light and pCO2 on two strains of T. erythraeum Ehrenb. (GBRTRLI101 and IMS101) in laboratory semicontinuous cultures. Elevated pCO2 stimulated gross N2‐fixation rates in cultures growing at 38 μmol quanta · m−2 · s−1 (GBRTRLI101 and IMS101) and 100 μmol quanta · m−2 · s−1 (IMS101), but this effect was reduced in both strains growing at 220 μmol quanta · m−2 · s−1. Conversely, CO2‐fixation rates increased significantly (P < 0.05) in response to high pCO2 under mid‐ and high irradiances only. These data imply that the stimulatory effect of elevated pCO2 on CO2 fixation and N2 fixation by T. erythraeum is correlated with light. The ratio of gross:net N2 fixation was also correlated with light and trichome length in IMS101. Our study suggests that elevated pCO2 may have a strong positive effect on Trichodesmium gross N2 fixation in intermediate and bottom layers of the euphotic zone, but perhaps not in light‐saturated surface layers. Climate change models must consider the interactive effects of multiple environmental variables on phytoplankton and the biogeochemical cycles they mediate.