bluuebunny/crossref_metadata_2025 huggingface dataset:
ONLY IN DREAMS: a case report of sleep deprivation psychosis
Authors: Brás J. , Costa A. , Sousa R. , Vaz R. , Martins J. , Almeida E. , Abreu J. , Costa A.
Published: September 2022

Introduction

Sleep is essential for an adequate neurobiological functioning, being implicated in several cognitive functions. Even in healthy individuals, sleep deprivation can lead to a number of psychopathological changes, including perceptual distortions, hallucinations and delusions. Thus, the resulting clinical picture may be similar to a psychotic disorder.

Objectives

To present a clinical case of psychotic symptomatology induced by sleep deprivation.

Methods

Patient’s clinical file consultation and literature review using the search engine Pubmed® and the keywords: “sleep deprivation”, “sleep loss” and “psychosis”.

Results

We present the case of a 41-year-old woman with a history of an episode of mood changes with psychotic symptoms that was preceded by a period of total insomnia. No psychotropic drugs since then and no relapses. In May 2020, she was admitted in psychiatry department due to clinical picture composed by significant psychomotor slowing, drowsiness, slowed speech, verbal visual, tactile and auditory hallucinations accompanied by grandiose delusions. These symptoms were preceded by total insomnia with one week of duration. In the hospital was administered quetiapine 100mg and lorazepam 2.5mg to aid in the recovery of sleep deprivation and concomitantly aripiprazole 15mg was prescribed. The patient presented a rapid and significant clinical improvement. Currently, it is without any type of medication and without psychopathological changes.

Conclusions

The clinical picture present in this case report was triggered after a significant period of sleep deprivation. Thus, it illustrates the role that sleep has in the development of psychiatric symptomatology, sometimes difficult to differentiate from psychiatric disorders.

Disclosure

No significant relationships.
Promoting better mental health care for patients with psychosis by focusing on differences in causal beliefs between patients and clinicians
Authors: Rosenthal Oren R. , Roe D. , Hasson-Ohayon I. , Zisman-Ilani Y.
Published: September 2022

Introduction

Nonadherence to antipsychotic medications and disengagement from psychiatric services are frequent among people with psychosis. Research indicates how the beliefs of people with psychosis about the etiology of their symptoms, or their causal beliefs, affect treatment choice and outcomes. Yet, there is less research on causal beliefs of clinicians or on the impact of patient–clinician disagreements on treatment and adherence.

Objectives

This review aimed to explore the scope of the literature focusing on clinicians’ causal beliefs and to map the degree of patient–clinician concordance in causal beliefs.

Methods

A systematic literature search of PubMed, Embase, Scopus, PsycInfo, and ASSIA and a grey literature search of PsyArXiv and MedNar yielded 11,821 eligible references.

Results

Forty-two articles indicated that whereas clinicians endorse mainly biogenetic beliefs (9/15 articles, 60%), patients endorse mainly psychosocial causal beliefs (16/31, 52%) and other non-biogenetic causal beliefs (8/31, 26%). Most studies did not compare causal beliefs of people with psychosis and their treating clinicians.

Conclusions

While clinicians and people with psychosis often hold complex causal models, a gap in causal beliefs between these groups appears to exist, which may affect the therapeutic relationship and pose barriers to treatment adherence. Future studies should address this gap by developing interventions that facilitate open communication about causal beliefs to promote treatment alliance and an agreed-on treatment plan.

Disclosure

No significant relationships.
Hormonal alterations due to antipsychotic-related hyperprolactinemia
Authors: Montejo A.L. , Buch B. , López M.J. , Arias M.T. , Corrales M.D. , Dominguez E. , Matos C. , Cortés B. , Santana Y. , Valrriberas I. , Matías J. , Prieto T. , Acosta J.M.
Published: September 2022

Introduction

The use of antipsychotics (APS) is essential. Despite their great efficacy, some of them are associated with an increase in prolactin levels that can lead to hormonal changes needing to be identified and managed [1,2,3]. Hormonal changes use to have clinical implications including hypogonadism, infertility and sexual dysfunction

Objectives

To evaluate possible hormonal alterations and some clinical implications produced by hyperprolactinemia (HPRL) derived from the use of some antipsychotic compounds.

Methods

A complete fasting blood test was performed on a sample of 113 subjects (69 men and 44 women). 54% (n = 61) showed a normal prolactin level and 46% (n = 52) showed hyperprolactinaemia ( >50ng / ml). On the global sample, 39.8% (n = 45) was treated with some hyperprolactinemic drug , mostly risperidone and paliperidone.

Results

Some differences were found depending on the gender of the subjects. A highly significant inverse relationship between the values of prolactin and testosterone was found in males (p=0.020, r=-0.285). In females, increased prolactin level was significantly related to decreased cortisol values.

Conclusions

Antipsychotic-related Hyperprolactinaemia ( mainly risperidone and paliperidone) is related with a decrease in testosterone levels in males and with an increase in cortisol levels in females.

Disclosure

No significant relationships.
Pilot Study of the Brief Negative Symptom Scale (BNSS) as a method for evaluation the required form of social service: institutional or non-institutional one
Authors: Kharitonova N. , Rusakovskaya O. , Papsuev O.
Published: September 2022

Introduction

Psychiatric care for persons suffering from chronic mental disorders and unable to live independently involves an assessment of their need for a certain form of social service. In Russia patients with schizophrenia account for over 40 % of all persons living in residential facilities for persons with mental disability (Kekelidze, 2020). Their clinical picture is most often determined by negative symptoms, which makes it advisable to use the BNSS scale (Kirkpatrick, 2011).

Objectives

Pilot testing of the BNSS scale in patients, living in residential facilities for persons with mental disability.

Methods

With Russian-language version of the BNSS scale (Mucci, 2019; Papsuev, 2020); CGI-S; Standardized protocol of forensic psychiatric examination in cases of deprivation, restriction, restoration of legal capacity (Kharitonova, 2021) we examined 15 persons (Age: M=54,2; SD=8,6) suffering from schizophrenia and living in residential facilities.

Results

In three subjects the BNSS survey was not possible. The remaining 12 had a total score from 6 to 61 (M = 29.08; Med = 25; Std.Dev. = 17.98) with maximum score in the Asociality subscale (Item 6: M = 3.25; Med = 4; Std.Dev. = 1.76). CGI-S significantly correlated with indicators on the scales «Avolition: inner experience» (r = 0.68, p <0.05), «Blunted affect : vocal expression» (r = 0.64, p <0.05). According to full examination community-based services were recommended for two women with BNSS overall score 6 and 11.

Conclusions

Our pilot study demonstrated that the BNSS can be successfully used as one of methods in comprehensive examination to determine the form of social services.

Disclosure

No significant relationships.
Clinical determinants of social media use in patients with schizophrenia and schizo-affective disorder
Authors: Elleuch O. , Zouari L. , Smaoui N. , Gassara I. , Omri S. , Feki R. , Ben Thabet J. , Maalej M. , Charfi N. , Maalej M.
Published: September 2022

Introduction

Social media networks are becoming omnipresent in our lives, and more and more available to everyone including patients with mental illnesses.

Objectives

Our study aimed to examine the prevalence of social media use in individuals with schizophrenia and schizoaffective disorder, and to examine the association of severity of symptoms with social media use.

Methods

A total of 38 patients with schizophrenia or schizoaffective disorder were recruited from the outpatient unit of the department C of psychiatry in Hedi Chaker hospital of Sfax, Tunisia. Socio-demographic information as well as details about their social media use were collected from all the patients. Severity of schizophrenia symptoms was assessed on the Positive and Negative Syndrome Scale (PANSS). A logistic regression was used to explore the association between social media use and clinical characteristics of the participants.

Results

Of the 38 study participants, 23.7% used social media. Facebook was the most popular social media site. The number of social media users were highest among participants aged 21–30 years old, married participants, residents of an urban region, employed participants and patients with a tertiary education level. Age and PANSS negative score were significantly and negatively associated with social media use.

Conclusions

Less than one fourth of patients with schizophrenia and schizoaffective disorder use social media and may be suitable candidates for treatment programs supported by social media platforms , especially those of a young age and a low severity of negative symptoms .

Disclosure

No significant relationships.
Suicidal tendencies in Schizophrenia patients
Authors: Pascariu A. , Bosun A. , Kalinovic R. , Vlad G. , Enatescu V.
Published: September 2022

Introduction

Suicide is one of the most frequent causes of death in schizophrenia patients, but the low insight in this pathology makes it difficult to identify persons at risk. The clinical picture of schizophrenia includes a wide variety of signs and symptoms, which make it hard to properly assess suicidal ideation.

Objectives

Our study was aimed at comparing tendencies among the clinical presentation and sociodemographic factors of schizophrenic patients with and without suicide attempts in their medical history.

Methods

We analysed the clinical data of 60 patients admitted to the Psychiatry Clinic of Timisoara with the diagnosis of Schizophrenia during 2020-2021. The PANNS-R scale was used for every patient, and each item was compared to the clinical data gathered.

Results

A positive history of suicide attempts was corelated to blunted affect, stereotyped thinking, lack of spontanety and flow of conversation, somatic concern, tension, unsual tought content, lack of judgment and insight. Total negative symptoms were correlated with psychiatric family history.

Conclusions

Considering a history of suicide attempts is a risk factor for suicide, more studies are needed to evaluate patients with such a history in order to identify the constelation of risk factors with a high predictibility value for suicide. This could help implement prophylactic measures in clinical practice that would decrease suicidal behaviour in schizophrenia.

Disclosure

No significant relationships.
COVID-19 and CAP: What Changed in Training and Practice for Early Career Child/Adolescent Psychiatrists?
Authors: Seker A.
Published: September 2022

Covid-19 pandemic has affected early career psychiatrists (ECP) and psychiatric trainees significantly. Child and Adolescent Psychiatry (CAP) specialists and trainees have a particular position in the pandemic as redeployments to adult units are possibly more disorientating for these psychiatrists normally working in paediatric settings. Redeployments and abrupt but potentially permanent changes to the delivery of service and training are explored via the Covid-19 and Early Career Psychiatrists survey which was prepared and disseminated by the EPA ECP Committee and the European Federation of Psychiatric Trainees (EFPT). The CAP related data from the survey will be discussed in this presentation and the implications on the future of CAP will be considered with particular emphasis on training.

Disclosure

No significant relationships.
Cycloid psychosis - from the past to the future: based on a case report
Authors: Pereira S. , Almeida A. , Pais J.
Published: September 2022

Introduction

The concept of cycloid psychosis has a long tradition in European psychiatry since it was introduced by Kleist in 1926. Nevertheless, this concept is not included explicitly in modern classifications, leading to a controversial discussion about its utility in current psychiatry.

Objectives

Starting from a case study, we intend to review the evolution of cycloid psychosis concept and analyze its role in modern psychiatry.

Methods

Non-systematic review of the literature and report of a case study.

Results

Following Kleist’s work, Leonhard described the three overlapping subtypes, and later Perris developed the first operational diagnostic criteria. Since then, this entity has shown a high diagnostic stability, validity and a good predictive diagnostic and prognostic value. We report a case of a 30-year-old woman, previous heathy, without regular medication, living with her parents and 5-year-old son, until she emigrated alone to Switzerland. After 10 days abroad, she was sent back to Portugal, and after organic disease and drug misuse exclusion, she was admitted in our inward with a clinical picture of perplexity, anxiety, thinking and behavioral disturbance with persecutory and poisoning delusions, auditory hallucinations, and total insomnia. Following rapid and full recovery, she was discharged 14 days later while being medicated with Paliperidone 3 mg/day and Lorazepam 4 mg/day, which was abandoned by her 2 months later, without relapse of the symptoms.

Conclusions

The current lack of a satisfactory system for categorizing acute, and remittent psychoses seems to be reason enough to remain awareness of this unique diagnostic entity, which is worthy of further investigation.

Disclosure

No significant relationships.
Aripiprazole lai two-injection start in a 16 year-old with Schizophrenia
Authors: Marpepa B. , Appignanesi C. , Orsolini L. , Volpe U. , Salvi V.
Published: September 2022

Introduction

Aripiprazole LAI is approved for the treatment of schizophrenia in adults. Recently, Europe and Canada approved the use of the two-injection start (TIS) regimen: two separate injections of 400 mg long-acting aripiprazole along with a single 20 mg dose of oral aripiprazole. Aripiprazole showed efficacy in the treatment of adolescents with acute schizophrenia in several controlled trials, leading to its approval for 13-17 year-old adolescents with schizophrenia by the EMA. However, the LAI formulation still remains off-label in adolescents.

Objectives

To demonstrate the efficacy and safety of the TIS regimen of aripiprazole LAI formulation in a 16 year-old adolescent with schizophrenia.

Methods

We evaluated the symptoms of schizophrenia and general severity by means of the PANSS and CGI scales. The scales were administered at hospital admission, after 3 weeks, 5 weeks, and at 4-weeks follow-up.

Results

At the admission the patient PANSS total score was 136, the CGI score of 7. Aripiprazole was started and up-titrated to 30 mg/day. After 3 weeks, the positive symptoms were significantly reduced; due to the persistence of negative symptoms, clozapine 100 mg/day was added. At week 5 the PANSS total score decreased to 81. Due to poor insight we proposed aripiprazole LAI with the two-injection start. One month later, global functioning and illness insight improved; PANSS score was 43, CGI score 2. There was no evidence of akathisia or other side effects.

Conclusions

Aripiprazole LAI showed good efficacy and tolerability in an adolescent with schizophrenia. The two-injection start regimen was a safe and viable option.

Disclosure

No significant relationships.
Women and Girls with Autism Spectrum Disorder
Authors: Potyrcha A.
Published: September 2022

Autism spectrum disorder (ASD) is characterized by a triad of difficulties including altered communication, impairements in social internactions, as well as restricted interests and repetitive behaviours. It used to be known as a predominantly male disorder, but recent research has shown that the male/female ratio is trending downward and that the actual estimate is about 3:1. Until now, diagnostic criteria have been developed based on research conducted primarily in male populations. However, in recent years, female autism has attracted scientific interest, revealing some unique features in the presentation of this disorder in girls and women. This presentation will focus on gender differences and characteristics of ASD in females, including personal descriptions and experiences of women diagnosed with ASD.

Disclosure

No significant relationships.
Assessment of sexuality among women in Morocco
Authors: Katir I. , Fatima Zahra C. , Korchi A. , Belbachir S. , Ouanass A.
Published: September 2022

Introduction

Having a healthy active sex life is essential to maintain good physical health and offer the possibility of establishing moments of mental well-being. Until now, not many studies have addressed this health aspect in our context, while problems related to intimate relationships remain one of the most frequent causes of consultation in psychiatry.

Objectives

The objectives of our study are: to assess sexuality among Moroccan women, analyze their sexual behavior with an epidemiological description, determine their sources of information, and identify the potential causes that could lead to lower their libido.

Methods

We conducted a cross-sectional study with around hundreds of women in the general population using the female sexual function index (FSFI), associated with a questionnaire that includes age, place of residence, origin, marital status, number of children, profession, social status, age of first sexual experience, details of different sexual practices, sources of information related to genital life, the means of contraception and the presence of comorbidities.

Results

Preliminary results show a limited understanding of sexuality among women of low socioeconomic status. Women with a high level of education are more fulfilled and this is due to the ease of access to information and care. Depression contributes greatly to lower libido and marital conflict.

Conclusions

Sexuality remains today one of the most taboo subjects in our country and more among the female population. Hence the need for sex education begins with self-knowledge, understanding of different practices, and psychological support for all women from a young age toward enduring a healthy flourishing sex life.

Disclosure

No significant relationships.
Neurodevelopmental disorders and gender dysphoria: a fertile relationship?
Authors: Soares Da Costa I. , Mota M.
Published: September 2022

Introduction

Development of gender identity is a complicated process. During this process it is thought that many factors play a role. Gender dysphoria is a condition where there is a mismatch between the assigned gender at birth and gender identity. Although scarce, literature shows that compared to cisgender individuals, transgender and gender-diverse individuals have higher rates of autism, other neurodevelopmental and psychiatric diagnoses.

Objectives

To describe posible relations and overlap between gender dysphoria and neurodevelopmental disorders.

Methods

Literature search in Pubmed and other similar platforms. Articles considered relevant under this theme were included.

Results

Autism spectrum disorders (ASD) and attention-deficit hyperactivity disorder (ADHD) can compromise health and may be more prevalent amongst individuals with gender dysphoria (GD). Symptoms such as attention difficulties, deficits in communication and social skills, obsessional interests, and stereotyped behaviour can significantly impact assessment of GD and the appropriate clinical care. With some overlapping symptoms, the potential for misdiagnosis is possible. Data about prevalence of this conditions in transgender community is of low quality, but ASD is more prevalent, ranging from 6-26%.

Conclusions

Studies demosntrate that neurodevelopmental disorders and other psychiatric conditions are more common in transgender and gender-diverse individuals. It is important that future studies focus on exploring the mental health outcomes of neurodevelopmental-trans individuals.

Disclosure

No significant relationships.
Minority stress and sleep disturbance: How does anxiety mediate the relationship between stress and sleep for a sample of sexual minority men?
Authors: Gibbs J. , Fusco R.
Published: September 2022

Introduction

There is growing evidence that sexual minority men (e.g., gay, bisexual) experience lower sleep quality when compared to their heterosexual peers. Minority stress (e.g., discrimination, victimization) may account for these differences, however little is known about these relationships and how generalized anxiety may play a role in sleep disturbance.

Objectives

Therefore, the aims of this study are to (a) understand the relationship between minority stress and sleep disturbance in a sample of sexual minority men, and (b) test whether these relationships are mediated by generalized anxiety.

Methods

In 2020, 241 sexual minority men were recruited across a south-eastern state in the USA. Participants were asked to respond to scales assessing perceived social stress, minority stress constructs (i.e., internalized homophobia, experiences of harassment, microaggressions), generalized anxiety, and sleep disturbance. Linear regressions were used to test the relationship between minority stress and sleep disturbance controlling for perceived social stress and to test mediation by generalized anxiety.

Results

Two minority stress constructs (experiences of harassment, and microaggressions) and perceived social stress were found to have a positive relationship with sleep disturbance. Generalized anxiety symptoms fully mediated the relationship between minority stress and sleep disturbance.

Conclusions

Because sleep quality has a profound impact on health, findings from this study suggest the need for psychological intervention to improve sleep for sexual minority men. Given that generalized anxiety fully mediates the relationship between minority stress and sleep, targeted anxiety-based interventions have the potential to reduce sleep disturbance disparities between heterosexual and sexual minority men.

Disclosure

No significant relationships.
Relative value of sleep and sleep-related complaints in people without sleep disorders: mediating role of cognitive, emotional and behavioral factors
Authors: Rasskazova E.
Published: September 2022

Introduction

High prevalence of dysfunctional beliefs about sleep and poor sleep hygiene in population (Perlis et al., 2011, Riemann et al., 2017) allow suggesting (Rasskazova, Tkhostov, 2012) a socially determined low value of sleep relative to other activities and demands.

Objectives

The aim was to reveal the role of the relative value of sleep and subjective quality of sleep in people without sleep disorders.

Methods

172 participants 18-62 years old without diagnosed sleep disorders answered three items about their relative sleep value, filled Insomnia Severity Index, Dysfunctional Beliefs About Sleep Scale (Morin, 1993), Behavioral Factors of Sleep Disorders Scale (Rasskazova, 2020) and Hospital Anxiety and Depression Scale (Zigmond, Snaith, 1983)

Results

56.3% -65.3% participants tend to neglect sleep for the sake of other activities in conflictual situation independent on gender and age. Sleep neglect is associated with poorer subjective sleep indirectly – through poor sleep hygiene, depressive emotions and postponement of the time to get up in the morning (β=.02-.09; 95%CI [.01-.17]). High value of healthy sleep is associated with poorer sleep quality if it leads to higher dysfunctional sleep beliefs and sleep rituals (indirect effects β=.04-.16; 95%CI [.01-.23]), but with better sleep quality if it leads to better sleep hygiene in the evening and less delay in getting up in the morning (β=-.04 - -.02; 95%CI [-.08-.00]).

Conclusions

Relative value of sleep might play a different role in the sleep regulation depending on which long-term beliefs, emotions, and behaviors it provokes. Research is supported by the Russian Foundation for Basic Research, project No. 20-013-00740.

Disclosure

Research is supported by the Russian Foundation for Basic Research, project No. 20-013-00740
Self-Regulation Processes in Patients with Alcohol Dependence (Pilot Study)
Authors: Fadeeva E. , Lanovaya A.
Published: September 2022

Introduction

The first stage of the psychological intervention is related to diagnostics

Objectives

Purpose of the study was to explore features of mental self-regulation processes in patients with diagnosis “Mental and behavioral disorders due to use of alcohol”.

Methods

The study involved 39 male patients with alcohol dependence, the average age of 43.6 ± 6 years. The experimental group (20 patients) was taking part in in-patient rehabilitation program, the duration of rehabilitation ranged 4-6 months. The control group included 19 patients of the in-patient addiction treatment department, with average duration of treatment 21 days. To assess self-regulation processes, questionnaires “Style of behavior self-regulation” (Morosanova V.) and questionnaire of volitional self-control (Zverkov A., Eydman E.) were used. To compare differences between two independent groups Mann-Whitney U-test was used

Results

There was a significant difference for the subscale “Persistence and perseverance” in “Volitional self-control” test (p≤0.05) for the control and experimental groups. Patients, involved in clinical rehabilitation program, have higher ranks comparing to patients got clinical treatment (22.2 and 17.7). The comparison of the results of the questionnaire “Style of behavior self-regulation” showed that there is a significant difference for subscales “Modeling of significant conditions” and “Independence” (p≤0.05); participants from the experimental group had higher mean rank in both cases.

Conclusions

Patients who took part in the long-term in-patient rehabilitation program had more stable motivation to achieve their goals, better self-regulation and activity planning skills, higher independence and self-confidence, they were less dependent on opinion of others. The identified features can be used in psychological programs aimed at improving planning skills, reducing behavioral rigidity, stabilizing self-esteem and improving adaptive capacity.

Disclosure

No significant relationships.
Danish Feasibility Study of a New Innovation for Screening and Brief Intervention for Alcohol Problems in Primary Care: The 15-method
Authors: Schøler P. , Søndergaard J. , Nielsen A.
Published: September 2022

Introduction

The 15-method: a new brief intervention tool for alcohol problems in primary care, has shown promising results in Sweden for mild to moderate alcohol use disorders.

Objectives

To evaluate the 15-method’s usability, organizational integration, and overall implementation feasibility in Danish general practice (GP) in preparation for a large-scale evaluation of the method’s effectiveness in identifying and treating alcohol problems in GP.

Methods

In the Central and Southern Region of Denmark, five general practices participated: seven doctors and eight nurses. Participants received half a day of training in the 15-method. Testing of implementation strategies and overall applicability ran for two months. A focus group interview, two individual interviews with the participating doctors, and five individual patient interviews concluded the study phase.

Results

indicate that implementation of the 15-method is feasible in Danish general practice. The healthcare professionals and patients were optimistic about the method and its possibilities. The method was considered a new patient-centred treatment offer and provided structure to a challenging topic. An interdisciplinary approach was much welcomed. Results indicate that the method is ready for large-scale assessment.

Conclusions

Implementation of the 15-method is considered feasible in Danish general practice, and large-scale evaluation is currently being planned. The results from the present feasibility study, and an overview of the large-scale evaluation, will be presented at the conference.

Disclosure

No significant relationships.
Climate change and substance use disorders – do we understand the risks?
Authors: Vergunst F. , Berry H.
Published: September 2022

Introduction

Climate change is increasing the frequency and intensity of severe heatwaves, storms, floods, droughts, and wildfires. These events cause widespread economic and social disruption and are undermining population health worldwide. Despite a growing literature on how climate change threatens mental health, its influence on harmful substance use has not been systematically addressed.

Objectives

We propose an explanatory framework explicating the plausible links between climate change-related stressors and an increase in harmful substance use.

Methods

We critically review and synthesise literature documenting the pathways, processes and mechanisms linking climate change to increased substance use vulnerability.

Results

Several plausible pathways link climate change to increased risk of harmful substance use worldwide. These include: (1) anxiety about the impacts of unchecked climate change, (2) destabilisation of psychosocial and economic support systems, (3) increasing rates of mental disorders, and (4) increased physical health burden. Children may face disproportionate risk due to their vulnerability to both mental disorders and substance use, particularly during adolescence. We argue that a developmental life-course perspective situated within a broader ‘systems thinking’ approach provides a coherent framework for understanding how climate change is aggravating the multiple, persistent, interacting risks that influence harmful substance use pathways.

Conclusions

Climate change is already undermining health and wellbeing of global populations. By inference, it is also aggravating pathway to harmful substance use. This is a critical psychosocial problem for individuals and communities alike. Conceptual and methodological work is urgently needed so that effective adaptive and preventive action can be taken.

Disclosure

No significant relationships.
Effect of original anticonvulsant ortho-fluoro-benzonal on immune cells functional properties at chronic ethanol intoxication
Authors: Markova E. , Savkin I. , Shushpanova Т.
Published: September 2022

Introduction

GABAa-receptors proved to be the molecular targets of ethanol on immune and nervous cells, potentiating alcohol influence. ortho-Fluoro-benzonal is known to be a circular urea derivative and an artificial ligand of GABA/BD-receptor and thus a potential candidate drug for alchoholism treatment.

Objectives

We have shown the alcohol motivation decrease under ortho-fluoro-benzonal influence in experiment. The investigation of molecular mechanisms and functional targets of this substance is an important step in understanding of molecular pathogenesis and approaches to managing alcohol addiction.

Methods

Splenocytes from male (CBAxC57Bl/6) F1 mice in a state of alcohol dependence owing to 6-month 10% ethanol exposure were aseptically obtained and cultured in presence of GABA, ortho-fluoro-benzonal and mitogens (LPS or concanavalin A). Proliferative activity of immune cells in vitro was estimated by means of radioactive 3H-thymidine incorporation.

Results

The intact animals’ splenocytes revealed increased spontaneous proliferation, increased T-mitogen stimulated and decreased B-mitogen stimulated proliferation in the presence of ortho-fluoro-benzonal. The immune cells from alcoholized animals, demonstrating increased spontaneous proliferative activity and weaken susceptibility to the mitogens, showed normal response patterns, except B-mitogen response case, under ortho-fluoro-benzonal inluence. Addition of GABA into the cultures didn’t cancel most positive effects of ortho-fluoro-benzonal inluence, proving existence of their GABAaR-independent pathways, mediated by other barbiturate receptors in addition to GABAaR-dependent
ones.

Conclusions

Immunomodulating properties of artificial GABA receptor ligand, ortho-fluoro-benzonal, in vitro has been shown. The compound may correct immune cells dysregulation caused by chronic ethanol exposure, so the original anticonvulsant has promise in the treatment of alcoholism.

Disclosure

The authors have not supplied a conflict-of-interest statement.
The relationship between sleep problems and gaming addiction in adults
Authors: Neily C. , Maalej M. , Gassara I. , Feki R. , Smaoui N. , Zouari L. , Ben Thabet J. , Omri S. , Charfi N.
Published: September 2022

Introduction

Prolonged exposure to Video games may have several negative cognitive and emotional consequences.However, a few investigations have explored the effects of video games addiction on sleep.

Objectives

To study the effects of gaming addiction on sleep patterns in young adults

Methods

We conducted a cross-sectional, descriptive and analytical study.Data were collected using a self-administered questionnaire on social networks targeting young adults between 18–40 years. We used the gaming addiction scale (GAS) in its validated Arabic short version. We also used the validated Arabic version of the Pittsburgh Sleep Quality Index (PSQI) to assess the sleep quality of our participants.

Results

One hundred and nine participants were included. The mean age was 29.6 ± 10.3. Males accounted for 60.6% of the study population. The mean Gas score was 13.11± 6.08.According to the GAS,25.7% were addicted gamers. The mean PSQI score was 7.25± 3.15. A poor sleep quality pattern (score > 6) was found in 59.6% of the participants. We found that the GAS score was significantly correlated to the total score of PSQI( P=0.003). We also found that the group with poor sleep quality had higher GAS scores (p= 0.014). We found a correlation between the GAS score and the following components of the PSQI: subjective sleep quality ( p= 0.01), sleep disturbances (p=0.024) and the use of sleep-promoting medication ( p=0.046)

Conclusions

Our study showed that video gaming behavior had a significant effect on sleep quality. This can have negative consequences on life quality, together with an impaired performance at awakening.

Disclosure

No significant relationships.
Internet addiction: Gender-associated differences in psychological characteristics
Authors: Ponizovsky P. , Skurat E. , Trusova A. , Shmukler A. , Grechany S. , Ilyuk R. , Soldatkin V. , Yakovlev A. , Kibitov A.
Published: September 2022

Introduction

Internet addiction (IA) is reported to cause significant negative psychosocial consequences. The gender specificity of psychological characteristics that are potentially significant for the formation of IA remains understudied.

Objectives

To identify gender-related differences in the psychological characteristics of people with IA.

Methods

100 subjects aged 16-34 years who scored 65 points or more on the Chinese Internet Addiction Scale (CIAS) were identified and divided into 2 groups by gender: group 1 (54 men) and group 2 (46 women). The individual psychological characteristics were assessed with: the Liebowitz Social Anxiety Scale (LSAS); the Bass-Perry Aggression Questionnaire (BPAQ); the Emotional Regulation Questionnaire (ERQ); the Adverse Childhood Experiences International Questionnaire (ACE-IQ); a short version of the Five-factor Personality Questionnaire (TIPI-RU) and the Cloninger Temperament and Character Inventory (TCI-125).

Results

Women were significantly more likely to experience fear of situations of interpersonal contact and action in public places (p=0.027). They experienced significantly more sexual violence in childhood (p=0.032) and were more likely to have personality traits such as “reward dependence” (p=0.002), “persistence” (p = 0.046), and “self-transcendence” (p=0.002). Men demonstrated physical aggression (p=0.009), suppressed emotions (p=0.019) significantly more often than women and characterized themselves as emotionally stable (p=0.048).

Conclusions

The gender differences identified in the cohort of individuals with IA can potentially be considered specific for this contingent, although such gender relationships can be observed in other forms of addiction and in the general population. The specificity of gender differences may reflect individual psychological markers of increased vulnerability to developing IA.

Disclosure

The study was financially supported by Russian Foundation for Basic Research within the framework of scientific project No 18-29-22079.
Personalized Care in Opioid Use Disorder maintained on Buprenorphine
Authors: Elarabi H. , Marsden J. , Alghafri H. , Adem A. , Lee A.
Published: September 2022

Introduction

Effectiveness of buprenorphine (BUP) is moderated by medication misuse diversion and non-adherence, and poor retention and high cost. Contingency Managment has added benefit to BUP with Take-home doses as the most preferred reward by Opioid Use Disorder patients.

Objectives

Examine the clinical effectiveness of a novel incentivised medication adherence and abstinence monitoring to enable contingent access to increasing BUP take-home doses.Explore associations with opioid use and retention. Contrast characteristics of polysubstance abusers (PSA) and response to BUP, with single opioid users.

Methods

Two-arm, pragmatic, 16-week outpatient RCT of BUP maintenance.Takehome doses were provided as stepped-approach upto 4-weeks contingent of abstinence (UDS) and adherence according to Therapeutic Drug Monitoring-TDM. Primary outcome and secondard outcomes were % negative UDS for opioids anx retention, respectively. -

Results

Opioid % negative UDS was 76.7% (SD 25.0%) in I-AAM versus 63.5% (SD 34.7%) in TAU (13.3%; 95% [CI] 3.2%–23.3%; Cohen’s d 0.44; 95% CI 0.10–0.87). In I-AAM, 40 participants (57.1%) were retained versus 33 (46.4%) in TAU [OR: 1.54; 95% CI 0.79–2.98). PSA (73.7%, n=104) and carisprodol use increases non-fatal overdose (OR) 3.83, 95% CI 1.25 to 11.71) and 5.31, 95% CI 1.92 to 14.65], respectively. Opioid and non-opioid UDS are positively associated. BUP elimination rate (BUP-EL.R) predicts 26.5% to 65% of negative opioid UDS [Beta - 89.95, 95% CIl -154.20 to -25.70, R2 0.22]. Family enagement increases retention by 3-fold.

Conclusions

BUP + incentivised TDM for contingent access to increasing take-home doses increased abstinence. BUP-EL.R seems promising in BUP treatment precision and BUP is clinically valuable in polysubstance abusers.Engaging family enhances retention.

Disclosure

No significant relationships.
Differences in addictive beliefs in people with psychostimulant addiction and in opioid addicts
Authors: Yan Y. , Gutkevich E.
Published: September 2022

Introduction

Today, a number of researchers consider the problem of addictive behavior as one of the most global problems for Kazakhstan and Russia. Some scientists consider CBT to be the most effective way to work with addictions. In our country there are no scientific works devoted to the study of addictive beliefs, so we decided to conduct such a study

Objectives

The Objective of the study was to identify the characteristic addictive beliefs of drug addicts with different type of addiction: opioids and synthetic cathinones (designer drugs called “salts”, “bath salts”)

Methods

Questionnaire of addictive beliefs by A, Beck, questionnaire of beliefs about cravings by A. Beck and F. Wright, clinical interview. Descriptive statistics and chi-square test were used for data processing

Results

People with opioid addiction are more likely to believe that their lives will become more depressive if they stop using drugs (p= 0.0347); that drug use is the only way to cope with pain in their life (p= 0.0347) and that they cannot cope with anxiety without drugs (p=0.009). Respondents who use synthetic psychostimulants endorse to believe that addiction is not a problrm for them (p= 0.0358).

Conclusions

Having categorized these beliefs in accordance with A. Beck’s classification, we came to the conclusion that “relief-oriented beliefs” are more typical for people who use opiates. The motive for use is often the desire to alleviate a negative emotional or physical state. For people using psychostimulants “salt”, “anticipatory beliefs” are more characteristic - the desire to experience euphoria and pleasant experiences

Disclosure

No significant relationships.
Alcohol abuse among women: a review with a gender perspective
Authors: Gonçalves Cerejeira J. , Santos Carrasco I. , Vallecillo Adame C. , De Andrés Lobo C. , Jiménez Aparicio T. , Queipo De Llano De La Viuda M. , Gonzaga Ramírez A. , Guerra Valera G.
Published: September 2022

Introduction

The harmful use of alcohol is an important risk factor for the health of the population around the world. The incidence of alcohol dependence in women is increasing and both its consumption pattern and its consequences have unique characteristics.

Objectives

To present a literature review focused on alcohol use disorder with a gender perspective.

Methods

Literature review.

Results

- Women use to start using alcohol sooner than men and this seems to be a risk factor to become addicted. - Due to physiological and psychological factors women experience more negative health effects from excessive alcohol use than men and it occurs at lower levels of use. - Psychiatric comorbidity associated with alcohol abuse such as anxiety and depression is more common in women and this in turn worsens the alcohol use disorder. - Alcohol consumption increases the vulnerability of women on several levels, including an increased risk of physical abuse.

Conclusions

Alcohol abuse among women deserves special attention and a specific intervention focused on the gender perspective.

Disclosure

No significant relationships.
Superusers experiences in using naloxone to reverse opioid overdose - A qualitative study
Authors: Troberg K. , Isendahl P. , Dahlman D. , Håkansson A.
Published: September 2022

Introduction

Since June 2018, multi-site overdose prevention education and naloxone distribution has been available in the County of Skåne, Sweden. Among the participants there are individuals who have used naloxone to reverse overdose on multiple occasions (three times or more). Situations of overdose management are characterized by different conditions which inevitably lead to different decisions and outcomes.

Objectives

To investigate the complex interaction of individual, social, and environmental factors of opioid overdose management, how these overdose situations affect responders´ lives, what impact prior experiences may have on engagement in future overdose situations and if needs of support to deal with these situations are met.

Methods

Qualitative study employing semi-structured interviews with individuals trained at needle exchange programs within the region who have used naloxone on more than two occasions to reverse opioid overdose. Interviews will be conducted during Q4 2021 and analysed thematically during Q1 2022.

Results

Preliminary clinical observations point to the ambivalence between positive consequences of empowerment and pride in saving lives, and negative feelings of prior decisions and the burden to engage in future overdoses, in addition to insufficient access to support when dealing with these negative consequences.

Conclusions

Not yet available.

Disclosure

No significant relationships.
A Structural Barrier to Healthcare: Stigma of Alcohol and Substance Use Disorders Among Health Care Workers
Authors: Yilmaz-Karaman İ.G. , Gündüz T. , Güleç G.
Published: September 2022

Introduction

Individuals with substance use disorders are considered unpredictable and violent by the public. Besides, health care workers (HCW) may have negative attitudes towards them, despite their knowledge about addiction; which is related to lower quality of care. In Turkey, addiction service users are predominantly male, over ninety percent; while women make up a large percentage of psychiatrists.

Objectives

The present study aims to evaluate if the HCWs level of stigma towards individuals with substance use disorder changes due to gender and mental health sector experience of the HCWs.

Methods

Within an online survey, participant HCWs answered Attitudes Towards Treatment of Substance Use Disorders Scale, Substance Addiction Stigmatization Scale, Alcohol Addiction Stigmatization Scale; in addition to sociodemographic questions.

Results

Three hundred ninety-eight HCWs were included in the analyses. 22.7% of them (n=91) were recruited in mental health sector. Mental health care workers had lower levels of stigma towards individuals with alcohol use disorders (14.78 vs 16.21, p=0.048) and substance use disorders (14.21 vs 20.09, p<0.001) and, lower levels of stigma towards addiction treatments (20.89 vs 23.93, p=0.007). Among mental health care workers, women scored higher numbers of stigmatization towards alcohol use disorder and addiction treatments (16.26 vs 12.98, p=0.003; 23.84 vs 17.29, p<0.001). On the other hand, women and men in other HCWs groups did not differ from each other in terms of stigmatization measurements (See Figure 1)

Conclusions

The gender of mental health care workers may be related to stigmatization towards addictive disorders. Future research should evaluate underlying factors.

Disclosure

No significant relationships.
Polysubstance Use After Frontal Lobe Syndrome: A Case Report
Authors: Ulusoy M. , Ergelen M.
Published: September 2022

Introduction

Frontal lobe syndrome (FLS) is a clinical condition characterized by personality and behavioral changes that usually occur after a traumatic brain injury (TBI). The main features of this syndrome are related to the deterioration of basic functions of the frontal lobe. Substance use disorder (SUD) is rare but also serious comorbiditiy seen after TBI.

Objectives

In this case report, we aimed to discuss a case who developed SUD after TBI.

Methods

Case report

Results

A 40-year-old male patient with history of using cannabis, methamphetamine, synthetic cannabinoid was admitted to our alcohol and substance use disorders research and treatment centre (AMATEM) inpatient unit for detoxification. He has reported that he was injured by a car accident five years ago, had a surgery and was hospitalized for a few months, and started to use substance to relieve pain. According to the medical records, the left frontal and temporoparietal regions were affected. He reported no history of substance abuse before injury, no previous history of psychiatric admission. Personality and behavior changes had been observed after TBI. In the first examination he had depressed mood and loss of interest. Sertraline (gradually titrated up to 150 mg/d) and risperidone (1 mg/d) were started. Also N-acetylcysteine (1,200 mg/d) was added to reduce craving and drug-seeking behaviours for four weeks.

Conclusions

Frontal lobe syndrome and TBI may differ in terms of clinical presentations. Substance use may be a way to cope with mental, cognitive or behavioural changes, psychosocial stressors, anxiety, sleep problems or pain after TBI.

Disclosure

No significant relationships.