bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALYSIS OF THE MOBILE PAYMENT ONLINE SYSTEM APPLICATION OF THE PALOPO CITY REGIONAL GOVERNMENT BASED ON USER SATISFACTION
Authors: Pakkaja Ryan Alghazali , Luthfi Ahmad , Haryono Kholid
Published: December 2024

The electronic-based government system is now the best step for every region, and it certainly has a mission to educate the area regarding governance. Efforts have been made by the government to meet citizens' expectations for easier access to public services, which is the primary form of E-Government. Currently, the implementation of the existing E-Government concept can also be a new breakthrough in improving information technology-based services. One is the Mobile Payment Online System Application, built directly by the Palopo City Government through its strategic partner, Bank Sulselbar. However, special attention must still be given to implementing this application, especially to the system itself, which is less effective. Additionally, many individuals still take actions that are not in accordance with the procedures, as evidenced by the fraud committed by application users. This research uses qualitative methods that provide descriptive data results, describing the data occurring in the field. The data generated using quasi-experimental methods will be calculated using the same Likert scale. This research shows that the Mobile Payment Online System Application still needs to be socialized again to the users of this application and requires application development in terms of tool updates and system updates. This can be seen from the respondents' responses through the questionnaire results table and suggestions from these respondents. Thus, the Mobile Payment Online System Application is still ineffective for implementation in Palopo City.
The Business Strategy Game: Implementación de un cuadro de mando integral
Authors: Orosio-Gómez Jesús Ismael , Flores-Flores Adán Jacinto , Bernal-González Idolina
Published: December 2024

Los estrategas organizacionales deben desempeñarse profesionalmente para lograr la máxima eficiencia y eficacia posible en toda acción realizada, lo cual, deberá verse reflejado en la adecuada gestión de las ventajas competitivas del ente dirigido y, de esta manera, superar los diversos retos y adversidades intrínsecos a su entorno. Por ello, el objetivo central del trabajo realizado es el establecimiento de las metas estratégicas de un negocio virtual mediante la formulación de un cuadro de mando integral (CMI), asimismo, se optó por utilizar el software especializado de toma de decisiones The Business Strategy Game (BSG). Dicho paquete electrónico de negocios fue elegido por ser utilizado ampliamente de forma global, tanto en organizaciones para capacitar a la platilla gerencial, como en Instituciones de Educación Superior. Los resultados obtenidos del CMI desarrollado pueden ser capitalizados como un recurso practico para ejemplificar la elección de los indicadores más adecuados en la medición y evaluación de los aspectos financieros y no financieros organizacionales, es decir, los recursos tangibles e intangibles que son igualmente importantes para alcanzar el éxito esperado.
A STUDY ON DIGITAL PAYMENT SYSTEM IN INDIA.
Authors: R C Nagaraja
Published: December 2024

Demonetization created huge growth opportunity for digital payment in India and the digital wallet companies garbed the opportunities with both the hands to expand their market share. The Government of India has been taking several measures to promote and encourage digital payments in the country. As part of the Digital India campaign, the government aims to create a digitally empowered economy that is Faceless, Paperless, and Cashless. There are various types and modes of digital payments. Some of these include the use of debit/credit cards, internet banking, mobile wallets, digital payment apps, Unified Payments Interface (UPI) service, Unstructured Supplementary Service Data (USSD), Bank prepaid cards, mobile banking, etc. Digital payment methods are often easy to make, more convenient and provide customers the flexibility to make payments from anywhere and at any time The future of digital payments in India looks bright with the expected growth in the number of internet users and e-commerce market size.
Kinetics and microbiology of pulp silage from decorticated Agave salmiana leaves
Authors:   División de Ciencias Biológicas y de la Salud, Departamento de Biotecnología, Universidad Autónoma Metropolitana-Iztapalapa, Ciudad de México, 09340, Mexico, Alcantar-Morales Sarahí Lissete , Ramírez-Ortiz Akari , Gallardo-Martínez Diego , Favela-Torres Ernesto , Cruz-Guerrero Alma Elizabeth , Viniegra-González Gustavo
Published: December 2024

A new machine for decortication of residual leaves of Agave salmiana was developed, yielding, juice (43 ± 6 %), wet pulp (25 ± 3 %), and wet fiber (18 ± 4 %) with an overall 86 ± 2 % recovery. Production of lactic acid (LA) and acetic acid (AA) in micro silages of wet agave pulp were assessed together with the evolution of lactic acid bacteria (LAB) and mesophile bacteria (MB) populations. LA spontaneous fermentation was followed by a two stage first order kinetics model (R2 = 0.89), At the start (pH = 5) MB population was 100 times higher than LAB = 1xE8 CFU/g. Fermentation peak was reached at 11 days when pH = 4, LA = 119 g/kg, LAB = 4xE9 CFU/g, and MB = 1xE8 CFU/g showing that LAB overgrew MB. Average AA values were negligible during the first month. After two months, LA and AA titers were 80 and 40 g/kg, respectively. Pasteurized pulp with LAB < 1E2 CFU/kg showed, significant LAB growth after one week of silage (3xE7 CFU/g). Inoculation of pasteurized pulp by selected LAB strains produced lower counts (8xE9 CFU/g) as compared to spontaneous fermentations (9xE10 CFU/g). Hence, spontaneous agave pulp fermentation is a reliable process for conservation of agave pulp and seems worth scaling-up as the basis for ruminant production in the dry lands of Central Mexico. It remains to develop the utilization of the juice and fiber fractions of A. salmiana as the basis for new biochemical and textile industries.
Formação continuada de professores e tecnologias digitais: reflexões e desafios na prática de ensino
Authors: Da Silva Bento Eullir
Published: December 2024

Este trabalho tem com o objetivo refletir sobre a formação continuada docente e os desafios para a prática docente sob a perspectiva do uso das Tecnologias Digitais de Informação e Comunicação (TDIC). Em relação aos procedimentos metodológicos, segue-se uma abordagem qualitativa que permite a descrição dos fenômenos de forma mais aprofundada. Para isso, utilizou-se da pesquisa bibliográfica. Dessa forma, percebeu-se que a formação continuada do professor é crucial para o uso das tecnologias nos processos educativos. Além disso, foi notado que os desafios listados são diversos, desde o engajamento com a Cultura digital até a adequação e a estruturação das escolas em todo o Brasil.  É notório que os alunos enfrentam dificuldades e desafios que envolvem o ambiente escolar e familiar, o que tem um grande impacto na prática pedagógica do professor, de acordo com as Tecnologias Digitais de Informação e Comunicação (TDIC).
Metodologia 6A: uma proposta para a produção audiovisual por professores de Ciências da Natureza
Authors: Amaral Gonçalves Bianco André , Arroio Agnaldo
Published: December 2024

O ensino das Ciências da Natureza passou por profundas mudanças durante a pandemia da Covid-19. Professores e estudantes foram obrigados a se adaptarem ao ensino remoto emergencial, no qual o uso de vídeos adquiriu grande importância. No entanto, não houve tempo suficiente para a formação dos professores para a produção e seleção de vídeos. Em nossa revisão bibliográfica verificamos que o uso de vídeos não é trivial, muito menos a sua produção. Foram encontrados poucos trabalhos que apresentassem métodos capazes de habilitar os professores à produção audiovisual com qualidade conteudística e artística. Nossa proposta foi desenvolver e aplicar uma nova metodologia chamada de 6A, que reproduz as seis atividades fundamentais da produção audiovisual profissional: roteiro, produção, direção, captação de vídeo, captação de áudio e edição. A metodologia foi aplicada em um curso de formação continuada oferecido a professores de Ciências da Natureza da rede pública de ensino do Brasil. A análise dos vídeos produzidos por esses professores demonstrou que foi possível habilitá-los à produção autoral de vídeos com a qualidade almejada. Concluímos que é possível promover a alfabetização midiática de professores de Ciências da Natureza, de modo a que eles sejam capazes de produzir vídeos para as suas aulas e para a divulgação científica.
Cyberbullying entre adolescentes durante ensino remoto: comparativo entre escolas públicas e privadas
Authors: Cedraz Morais Aisiane , De Souza Leitão Dielly , Vieira Farias Raquel , Da Silva Araújo Rebeca , De Lima Souza Sinara
Published: December 2024

Compreender os conhecimentos de cyberbullying entre adolescentes escolares oriundos de escolas públicas e privadas. Trata-se de um estudo de abordagem qualitativa, descritiva e exploratória. A coleta de dados foi realizada através de entrevista com roteiro semiestruturado, com adolescentes de duas escolas da rede pública e outras duas da rede privada em uma cidade do interior da Bahia, que vivenciaram a educação de modo remoto durante a pandemia da COVID-19. Foram entrevistados dezesseis adolescentes, destes nove eram provenientes de escolas públicas e os demais das escolas privadas. Pesquisa foi aprovada pelo Comitê de ética em pesquisa e respeitou os aspectos éticos em todas as etapas. Emergiram três categorias temáticas: Compreensão do Cyberbullying pelos adolescentes, Comparação entre Bullying e Cyberbullying e Estratégias de Prevenção do Cyberbullying, por meio das quais foi possível perceber a disparidade entre as redes de educação a cerca do cyberbullying, bem como a importância da educação continuada com os adolescentes sobre a   prevenção da violência. A partir dos relatos dos adolescentes urge a importância de estratégias que possibilite a compreensão sobre o cyberbullying e os modos que ele se manifesta, a fim de estabelecer estratégias que promovam a cultura de paz.
Tornando a sustentabilidade uma realidade: aplicação da metodologia G5 ambiental em uma escola pública de Caruaru-PE
Authors: Clara Rocha Maria , Lima da Silva Gilson
Published: December 2024

No passado, os seres humanos mantinham uma relação simbiótica com a natureza, essencial para sua sobrevivência. Com o avanço científico, a exploração dos recursos naturais aumentou, resultando em práticas prejudiciais ao meio ambiente. Diante desse cenário, a Educação Ambiental surgiu como uma ferramenta crucial para mitigar os impactos negativos das atividades humanas na saúde e na qualidade dos recursos naturais. Este estudo visa implementar a Metodologia G5 Ambiental em uma escola pública em Caruaru-PE, envolvendo cinco eixos: gestão de água, energia, resíduos sólidos, fauna e flora, e conhecimento. Através de palestras e vídeos educativos, os alunos são engajados em projetos sustentáveis, promovendo a conscientização ambiental. Cada eixo possui um projeto específico: economizadores de água, aquecedores solares feitos com garrafas PET, sistemas de coleta seletiva e compostagem de resíduos orgânicos, e uma horta medicinal com plantas nativas da caatinga. O quinto eixo, gestão do conhecimento, integra todas as iniciativas, permitindo a participação ativa da comunidade. Essas ações não apenas transformam o ambiente escolar, mas também promovem sua sustentabilidade a longo prazo, formando cidadãos mais conscientes e comprometidos com a preservação ambiental. Os projetos colocados em prática apresentaram resultados animadores, demonstrando a melhoria das condições escolares e despertando uma consciência de sustentabilidade.
Grupos de pesquisa e a formação de professores pesquisadores em educação financeira
Authors: Freitas de Aguiar Reullyanne , Alexandre de Lima Sales Francisco , Luna Neres Raimundo , Sofia da Cunha Rodrigues Alexandra
Published: December 2024

A educação financeira vem sendo inserida progressivamente no contexto escolar. Uma ação que contribui para que os professores e formadores de professores realizarem essa inserção da melhor forma é a participação em Grupos de Pesquisa. As leituras e discussões no âmbito dos grupos de pesquisa poderão contribuir para a sua prática de ensino. Assim, objetiva-se analisar como emerge a temática de educação financeira nos Grupos de Pesquisa institucionalizados da área de educação e matemática presentes no Diretório dos Grupos de Pesquisa (CNPq). Esta pesquisa qualitativa identificou 11 grupos focados na educação financeira, com 12 linhas de pesquisa. Todos eram chancelados por instituições públicas e a maioria dos pesquisadores eram professores de matemática. Além de atuarem na formação de professores, a participação em grupos impactava seu desenvolvimento profissional. Convém destacar que as redes sociais destacaram a importância da colaboração entre pesquisadores. Observou-se que a educação financeira discutida pelos Grupos de Pesquisa em âmbito escolar visa desenvolver a capacidade crítica e reflexiva dos estudantes, preparando-os para decisões financeiras informadas. Isso confirma a importância de se abordar a educação financeira nos Grupos de Pesquisa para fortalecer a formação de professores e melhorar a prática educativa.
Perlindungan Hukum Bagi Petani Terdaftar Penerima KUR Pada Kasus KUR TANI Fiktif Di Kabupaten Lombok Timur
Authors: Zahara Annisa , Wardani Nizia Kusuma
Published: December 2024

The distributor of Farmer's People's Business Credit (KUR TANI). Thisresearch uses a type of normative research with a statutory approach method(Statute Approach), conceptual approach (Conceptual Approach), and caseapproach method (Case Approach) to describe the problem. Based on the resultsof the research and discussion, it was concluded that the forms of legal protectionfor registered farmers who receive KUR are divided into 2 (two), namelypreventive legal protection and repressive legal protection, and the provision ofsanctions or legal responsibility can be in the form of administrative sanctions,civil sanctions, and criminal sanctions. The procedure that farmers can carry outif their data is misused is to resolve disputes through litigation.Keywords: Credit; Fictitious; Legal protection
Perlindungan Hak Cipta Atas Seni Tari Bali Cendrawasih Berdasarkan Undang -Undang Nomor 28 Tahun 2014 Tentang Hak Cipta
Authors: Widyantari Putri Ida Ayu Puspita , Setiawan Yudhi
Published: December 2024

This research aims to determine the copyright protection for the Balinese Cendrawasih Dance according to Law Number 28 of 2014 concerning Copyright and to determine the legal sanctions if there is a copyright violation of the Cendrawasih Dance according to Law Number 28 of 2014 concerning Copyright. The research method used is normative legal research with a statutory, conceptual, and case approach. This approach uses a descriptive-qualitative data analysis method, namely the normative analysis of legal material obtained from document studies relating to copyright protection for the Balinese Cendrawasih dance according to Law Number 28 of 2014 concerning Copyright. This research explains that legal protection for the Cendrawasih Dance copyright can take the form of preventive protection, namely by registering the copyright with the DJKI. Furthermore, repressive protection can be achieved in two ways; litigation and non-litigation. In the context of copyright infringement in works of art, legal sanctions play an essential role in maintaining justice and respecting the rights of creators. In general, copyright infringement can be divided into two main categories; copyright infringement from a civil perspective and copyright infringement from a criminal perspective. Sanctions for this criminal act are regulated in articles 113, 116, and 118 of Law Number 28 of 2014 because this article states that copyright violators can be subject to imprisonment and fines. Meanwhile, legal sanctions for civil actions are regulated in Article 100 of the Copyright Law because this article gives creators or copyright holders the right to seek compensation for copyright violantions.
Tinjauan Yuridis Pelarangan Ekspor Benih Lobster Dan Impor Pakaian Bekas Berdasarkan Hukum Positif Di Indonesia
Authors: Humairah Indah , Sili Eduardus Bayo
Published: December 2024

Tujuan dari penelitian ini untuk menganalisis mengapa ekspor benih lobsterdan impor pakaian bekas dilarang dan untuk menganalisis pelaksanaan pelaranganekspor benih lobster dan impor pakaian bekas berdasarkan hukum positif diIndonesia. Larangan ekspor benih lobster disebabkan penurunan sumber dayalobster, serta larangan mengekspor lobster yang sedang bertelur atau dengan ukurankurang dari 200 gram. Larangan impor pakaian bekas disebabkan adanya potensijamur dan bakteri yang dapat membahayakan kesehatan manusia. Perdaganganpakaian impor bekas dapat merugikan industri domestik dibidang konveksi dangarment. Pelaksanaan Pelarangan Ekspor Benih Lobster dan Impor Pakaian BekasBerdasarkan Hukum Positif di Indonesia belum berjalan dengan efektif.
Perlindungan Hukum Karya Film Terhadap Penyebaran Konten Film Oleh Pihak Lain Melalui Youtube Berdasarkan UU No.28 Tahun 2014 Tentang Hak Cipta
Authors: Thauty Fatimah Fortuna , Saleh Moh.
Published: December 2024

Penelitian ini bertujuan untuk mengetahui terkait perlindungan hukum terhadap karya film yang disebarkan oleh pihak lain melalui youtube berdasarkan Undang-Undang Nomor 28 Tahun 2014, serta bagaimana tanggung jawab hukum atas pelanggaran terkait penyebaran konten film tanpa izin melalui youtube. Jenis penelitian ini adalah penelitian hukum normatif dengan metode pendekatan perundang-undangan dan pendekatan konseptual, dengan teknik pengumpulan data adalah studi pustaka/studi dokumen. Berdasarkan hasil dari penelitian adalah bentuk perlindungan hukum terhadap penyebaran konten film tanpa izin melalui youtube terdiri dari perlindungan preventif berupa adanya pengawasan terhadap tindakan pelanggaran yang berkaitan dengan penyebaran karya film tanpa izin melalui youtube dan perlindungan represif ialah adanya tindakan penutupan akses pada akun youtube pihak yang melanggar serta adanya ancaman sanksi berupa denda dan penjara. Tanggung jawab hukum pelanggaran terkait penyebaran karya film tanpa izin terdiri dari pertanggungjawaban secara perdata dan pertanggungjawaban secara pidana.
Peran Strategis Rezim Hak Kekayaan Intelektual Dalam Mendukung Penguatan Ekonomi Kreatif
Authors: Opan Satria Mandala  , Teguh Iman Pribad  , Muharis  , Bagas Anggara  , Muhammad Taufik
Published: December 2024

Lombok Tengah memiliki potensi besar dalam industri kreatif, termasuk kerajinan tangan, seni pertunjukan, dan pariwisata. Namun, kurangnya pemahaman tentang perlindungan Hak Kekayaan Intelektual dapat menghambat pertumbuhan sektor ini dengan rentannya karya seni dan inovasi lokal terhadap pencurian dan penyalahgunaan oleh pihak lain. Tulisan ini bertujuan untuk melakukan analisis mendalam mengenai peran HKI dalam mendukung penguatan pertumbuhan sektor ekonomi kreatif di Lombok Tengah. Metodeologi yang digunakan adalah Metode Normatif-Empiris dengan Pendekatan Undang-undang, Konseptual, Teori, Kasus, dan Interdisipliner. Hasil dan temuan dari analisis ini menyoroti beberapa poin penting. Pertama, pemahaman yang kurang tentang perlindungan HKI di Lombok Tengah berpotensi menghambat pertumbuhan sektor ekonomi kreatif, terutama dalam industri kerajinan tangan, seni pertunjukan, dan pariwisata. Kekurangan ini menyebabkan rentannya karya seni dan inovasi lokal terhadap pencurian dan penyalahgunaan oleh pihak lain, yang pada gilirannya dapat merugikan para pelaku ekonomi kreatif setempat. Untuk mengatasi hal ini, diperlukan skema pembiayaan berbasis kekayaan intelektual yang dapat memberikan insentif dan perlindungan yang lebih kuat bagi para pelaku ekonomi kreatif. Peran Pemerintah Daerah Lombok Tengah dalam skema pembiayaan ini sangat penting. Pemerintah daerah dapat memberikan dukungan finansial, memberikan fasilitas, serta mengkoordinasikan program-program yang bertujuan untuk meningkatkan kesadaran dan pemahaman tentang perlindungan HKI di kalangan pelaku ekonomi kreatif lokal. Dengan adanya keterlibatan aktif Pemerintah Daerah, diharapkan skema pembiayaan berbasis kekayaan intelektual dapat berjalan dengan efektif dan memberikan manfaat yang optimal bagi pertumbuhan sektor ekonomi kreatif di Lombok Tengah.
Spatial Analysis of Drinking Water Quality and Environmental Sanitation on the Incidence of Diarrhea in Toddlers
Authors: Fernando P Nickolas , Raharjo Mursid , Nurjazuli Nurjazuli
Published: December 2024

Diarrhea is a common symptom of gastrointestinal infection caused by various bacterial, viral, and parasitic organisms and is characterized by loose stools and increased frequency when infected. Sanitation factors are closely related to environmental health and can affect the level of public health. The absence of a spatial picture of areas that are vulnerable to an increase in cases of children under five years old diarrhea complicates important case finding efforts to prevent outbreaks. The purpose of the study was to spatially analyze the effect of drinking water quality and sanitation on the incidence of diarrhea in children under five years old in the Administrative City of West Jakarta in 2023. This study used a quantitative method with a Cross Sectional research design and an ecological study with a spatial approach to determine the correlation of risk factors with cases of diarrhea in children under five years old geographically. The results of the study showed that the quality of environmental sanitation between the diarrhea group in the last 3 months and the no diarrhea group in the last 3 months had a value (p value = 0.373), water quality (p value = 0.036) with PR 1.840, CTPS habits (p value = 0.100) with PR 1.509, and type of drinking water source (p value = 1.151) with PR 1.442. And the water quality variable is the most dominant factor related to the incidence of diarrhea in children under five years old  in the West Jakarta Administrative City in 2024. The results of the multivariate analysis of logistic regression with the ward conditional backward method p value = 0.32 with PR = 4.110 CI = Low 1.129 and upper 14.96 which shows that children under five years old with drinking water quality that does not meet the requirements have a 4.110 greater chance than toddlers whose drinking water quality meets the requirements in the ODF sub-district in the West Jakarta Administrative City
Efficacy of Vitamin E Versus Pioglitazone in Treating Non-Alcoholic Fatty Liver Disease (NAFLD) without Diabetes “Decoding the Exodus of Liver Health”.
Authors: Muhammad Owais Fazal  , Ghulam Abbas Tahir  , Yasir Yaqoob  , Ahmad Zeeshan  , Rabia Sharif  , Muhammad Usman Musharraf
Published: December 2024

Objective: To compare the effectiveness of vitamin E in comparison with Pioglitazone in the management of NAFLD without Diabetes. Study Design: Randomized Control Trial. Setting: Outpatient Department of Allied Hospital, Faisalabad. Period: Dec 2023 to May 2024. Methods: The Ethics Review Committee of Faisalabad Medical University was taken on board and patients having the characteristics of the set Inclusion Criteria were enrolled as allowed. Selected individuals were counseled regarding the study and their consent was sought. Using a computer-generated random number table, two main groups were formed out of the participants, Group A and Group B. Group A was given 800IU of Vitamin E daily. Group B received Pioglitazone 30mg daily. Patients were monitored for efficacy over three months by tracking ALT levels as specified in the operational definition. Follow-up was ensured through contact numbers. Results: In our study of 722 cases (361 in each group), the mean age was 41.25±6.41 years in Group A and 41.23±6.56 years in Group B. Males comprised 60.11% (n=217) of Group A and 59.56% (n=215) of the Group B, while females accounted for 39.89% (n=144) out of Group A and 40.44% (n=146) of the Group B. Efficacy comparison showed that 49.72% (n=147) in Group A and 31.30% (n=113) in Group B achieved efficacy, with a p-value of 0.008, pointing out a considerable difference. Conclusion: Our study succeeded in establishing the better efficacy of Vitamin E in treating NAFLD compared to Pioglitazone.
Anterior Laparoscopic Approach Combined with Posterior Approach for Lumbosacral Neurolysis: A Case Report
Authors: Sheng Wang , Nan Lu , Yongchuan Li , Xiaohuang Tu , Aimin Chen
Published: December 2024

Background and importance: Sacral fractures often lead to injuries of the lumbosacral nerve, which will cause tremendous damage to the patient’s motor and sensory functions. At present, the most commonly used surgical method is the posterior median approach, the extent and degree of neurolysis are often insufficient, so the effect of neurolysis is not well, and the functional recovery of patients after operation is often incomplete.
Clinical presentation: The patient was a 17-year-old male who accidentally fell from a height and landed on his hip. The main clinical feature of the patient was persistent radiating pain in the right lower extremity with right lower limb sensorimotor disorder. The results of the X-ray examination indicated a sacral fracture and a right pubic fracture. After the injury, the patient underwent pelvic internal fixation surgery within 72 hours. Then 6 months after the surgery, there was no significant improvement in right lower limb function, and the patient came to our hospital seeking treatment. Considering the severe lumbosacral plexus injury and the history of surgery, we performed an “Anterior surgery approach combined with posterior approach for lumbosacral neurolysis” for the patient, postoperative radiation pain disappeared completely, and there were significant improvements in the muscle strength of some muscles and sensory function.
Conclusion: The relaxation of the lumbosacral plexus is usually performed through a single surgical approach, which has great limitations in the effect of relaxation. Here, we demonstrate a case in which posterior lumbar incision and anterior laparoscopic lumbosacral plexus neurolysis can benefit the patient, the lumbosacral nerve was released to a great extent. We aim to bring this case to the attention of our worldwide neurosurgical colleagues and share our surgical approach to assist those who may encounter this case in the future.
Efecto de ácido dehidroascórbico sobre la activación de RIPK1, durante la degeneración de neuritas.
Authors:   , MAGDALENA PARRA ROCÍO FERNANDA
Published: December 2024

En el SNC, la vitamina C se encuentra fundamentalmente como ácido ascórbico (AA), su forma reducida, molécula que actúa como agente antioxidante en el cerebro y cuya homeostasis se mantiene debido al acoplamiento neurona astrocito, donde AA ingresa a las neuronas y es oxidado a ácido dehidroascórbico (DHA), el cual es liberado al medio extracelular y reciclado por los astrocitos, permitiendo la mantención de las concentraciones de vitamina C en el parénquima cerebral. Sin embargo, condiciones patológicas agudas que incrementen los niveles de especies oxidantes pueden favorecer la generación extracelular de DHA, cuya acumulación lleva a modificaciones en el metabolismo neuronal y la muerte necroptótica, dada por la activación de RIPK1, proteína de andamiaje fuertemente regulada y que ha sido asociada a la progresión de la esclerosis lateral amiotrófica (ALS); sin embargo, se desconoce si bajo estas condiciones crónicas, DHA puede llevar a la activación de RIPK1 y a la pérdida de neuritas y axones.
Utilizando neurosferas in vitro, evaluamos el efecto de DHA sobre las neuritas, detectando una reducción significativa en su largo y ramificación, efecto prevenido tanto por la inhibición de RIPK1 como de caspasas, sugiriendo la activación de una vía apoptótica dependiendo de RIPK1. De forma similar, en neuronas motoras diferenciadas desde hiPSCs control y con una mutación en el gen C9ORF72, asociado a ALS, DHA incrementó la formación de varicosidades axonales, lo cual es prevenido por la inhibición de RIPK1, indicando un efecto que es reproducible en células humanas. Finalmente, utilizando el modelo animal de ALS, SOD1 G93A, observamos la presencia de astrogliosis reactiva en las astas ventrales de la médula espinal, evento asociado a un incremento en la expresión del transportador de AA, SVCT2, en astrocitos, y a la internalización del mismo en neuronas motoras, sugiriendo una pérdida del reciclamiento de vitamina C. Sin embargo, la inyección de DHA en el IV ventrículo de los animales disminuyó la expresión de SVCT2 en astrocitos, apuntando a una pérdida de características de gliosis reactiva que no está asociada a una mejora en la función motora. Por último, el análisis de marcadores de muerte mostró un incremento en la fosforilación de RIPK1 y el clivaje de caspasa-3 en neuronas motoras de médulas SOD1 G93A, junto con la ausencia de la proteína efectora de la necroptosis, MLKL, sugiriendo que la vía necroptótica sería prescindible para la progresión de ALS y, por el contrario, que la muerte neuronal observada en esta patología estaría asociada a la activación de una vía apoptótica dependiente de RIPK1.
Oxidación de glucosa y furfural sobre catalizadores de vo/cnt funcionalizados.
Authors:   , RODRÍGUEZ SULBARÁN PEDRO JOSÉ
Published: December 2024

En esta tesis fueron estudiados catalizadores de vanadio soportados en nanotubos de carbono en la reacción de conversión de glucosa en agua y oxidación de furfural en medio líquido y gaseoso. Se analizó el efecto de la funcionalización del nanotubo VO/CNT, VO/CNT-COOH y VO/CNT-NH2. Para mejorar el anclaje del vanadio, los catalizadores fueron sometidos a un proceso de dispersión ultrasónica. Los sólidos fueron caracterizados mediante análisis químico, TGA-DTG, DRX, isotermas de adsorción de N2, SEM, TEM, Raman, DTP-NH3 y XPS. La conversión catalítica de la glucosa en agua a 140°C y oxidación parcial del furfural en medio orgánico a 150°C se evaluó en un reactor batch y la reacción de oxidación parcial de furfural en fase gas en un reactor de flujo continuo entre 305 y 350°C. Se encontró que en reactor batch la lixiviación del vanadio, superior al 50% es responsable de la pérdida de actividad posterior al primer ciclo de reacción. En flujo continuo, la actividad se mantuvo en ciclos de reacción y para el catalizador VO/CNT-NH2 se alcanzó una conversión del 90% y una selectividad hacia anhídrido maleico del 40% a 320°C. Los reciclos mantuvieron la actividad catalítica con cambios en el rendimiento de la reacción hacia productos de oxidación parcial y total, CO y CO2.
Inquiring the flyrock to determine minimum safe distance of coal overburden blasting against residential area
Authors:   Indonesia Blasting Engineer Society, Handayana Raden , Shodik Fajar ,   Department of Technical Services & QC Hanwha Mining, Salahudin Sani ,   Department of Technical Services & QC Hanwha Mining
Published: December 2024

Fly rock is a rock fragmentation that is thrown as a result of blasting. Such fragmentation that is thrown beyond the specified safe distance can cause a damage to the infrastructure, mechanical equipment and humans. This study aims to determine the safe radius of the fly rock that resulting from blasting residential area which that has a distance 200-300 m and has potentially distressing to cause damage. Calculating of the flying rock throwing distance is carried out theoretically and actually with orientation to the distance between spaces, the distance between burdens, minimum stemming height, minimum hole depth, powder factor, average charge blast hole and distance initial burdens. For theoretical calculations, the save distance is calculated by empirical methods and dimensional analysis. Results of the study shows that the maximum distance of the actual fly rock throw is 05.31 m and based on the predictions using the Cratering Method, the maximum distance of fly rocks is 172 m with a safety factor of 2 and the maximum distance of fly rocks is 199.04 m with a safety factor of 2. Based on the actual and predicted data above, it is not safe for blasting locations that is less than 200 m from residential areas, that refers to the safe radius threshold based on the regulation of the Minister of Energy and Mineral Resources No. 1827 K/30/MEM/2018.
Ocular drug delivery systems: A comprehensive review of innovative formulations, challenges and opportunities
Authors: Mohammad Shoaib Shaikh Hamid  , Pooja R. Hatwar  , Ravindra L. Bakal  , Pooja V. Raut
Published: December 2024

The human eye's complex anatomy and physiology pose significant challenges to effective ocular drug delivery. This comprehensive review explores the eye's structure, ocular disorders such as cataracts, conjunctivitis, glaucoma, and fungal keratitis, and various ocular drug delivery systems. The review discusses the advantages and disadvantages of ocular drug delivery systems, including topical administration, intravitreal injection, subconjunctival routes, and implantable devices. Novel formulations such as nanosuspensions, microemulsions, liposomes, and niosomes are examined for their potential to overcome anatomical limitations and enhance bioavailability. The mechanisms of drug release, including diffusion, osmosis, and bio-erosion, are also discussed. Furthermore, the review highlights the importance of targeting specific ocular tissues and overcoming defensive mechanisms to achieve optimal therapeutic efficacy.
Development of environmental education: As a culture of sustainable development
Authors: Isabel Cristina Rodríguez Luna  , Alejandro Sánchez Varela
Published: December 2024

The study of the environment involves a certain natural phenomenon and the interactions that exist between man and his environment. Environmental Education, as a culture of sustainable development, with the aim of ensuring that resources are sufficient for the present and future generation. Anthropic activities, both individual and collective, have affected the environment. Advances in technology have brought advantages to man, generating goods and services to improve the quality of life and making life easier. However, collective actions by industry have contributed to a greater negative impact on the environment. Therefore, various strategies have been proposed to mitigate the damage caused, such as: generating educational programs to promote changes in values ​​and attitudes in society about the environment, generating cleaner productions, environmental reviews, eco-balances, impact assessment, among others; educational institutions have focused on environmental education, with the purpose of establishing a culture of sustainable development as a strategy for social change.
PEMANFAATAN LIMBAH BONGGOL JAGUNG MENJADI TEPUNG BERKUALITAS DALAM MENINGKATKAN POTENSI AGROPERTANIAN DESA SUKAMANAH
Authors: Gusman Tania Avianda , Rachmat Irfan Fauzi , Cahyani Mutiara Dwi , Nurdiyanti Dewi , Ramadhani Putri
Published: December 2024

Desa Sukamanah memiliki potensi pertanian yang cukup besar, khususnya dalam produksi jagung. Pada bagian jagung terdapat bonggol yang dimanfaatkan sebagai campuran pakan ternak maupun kompos. Limbah bonggol jagung yang tidak termanfaatkan akan menjadi pencemaran tanah dan air sehingga menggangu kesehatan dan pemandangan di desa Sukamanah. Adanya permasalahan tersebut dan kebutuhan ibu-ibu PKK dalam mengolah limbah menjadi tepung yang berkualitas dan bernilai ekonomi. Pelatihan pengolahan limbah bonggol jagung diharapkan dapat menambah pengetahuan terkait pengolahan limbah menjadi bernilai ekonomi serta menambah kemampuan dalam mengolah limbah bonggol jagung menjadi tepung yang berkualitas, serta mengubah tepung berkualitas menjadi cemilan yang bernutrisi tinggi. Para ibu PKK sangat antusias dengan adanya pelatihan pengolahan lombah bonggol jagung menjadi tepung berkualitas dan megubahnya menjadi cemilan berbagai variasi untuk peningkatan nutrisi anak.
PENGEMBANGAN PEMBELAJARAN PERLINDUNGAN DIRI PADA ANAK ATAS KASUS KEKERASAN SEKSUAL DI KB DAN RA PERMATA HATI JEBRES
Authors: Sugiarto Catur , Suryanadi Pram , Suryandari Retno Tanding , Auliarahman Lutfi , Oktaviana Anggerka Harum
Published: December 2024

Masa anak usia dini merupakan masa keemasan dimana di masa ini otak anak mengalami perkembangan paling cepat. Pada masa ini anak-anak memiliki rasa ingin tahu yang tinggi terkait sesuatu sehingga jenjang pendidikan pertama harus dilaksanakan dengan baik dan benar. Salah satu kegiatan yang dapat dilakukan untuk meningkatkan pemahaman anak adalah edukasi dengan pendekatan holistik dalam memberikan pendidikan perlindungan diri bagi anak usia dini. Pendidikan perlindungan diri dilakukan untuk mencegah kekerasan seksual yang terjadi pada anak. Sasaran utama kekerasan seksual sering terjadi pada makhluk polos dan lugu yang dilakukan oleh oknum untuk berbuat jahat. Anak-anak merupakan makhluk polos dan lugu sehingga pembelajaran mengenai perlindungan diri pada anak sangat penting. Metode pembelajaran dilakukan dengan perpaduan sosialisasi, dongeng cerita, dan media mewarnai objek anggota tubuh serta menggandeng pihak ketiga yaitu Ksatria Anak. Hasil penelitian menunjukkan bahwa pembelajaran dengan pendekatan holistik mampu meningkatkan pemahaman anak-anak tentang batasan pribadi, langkah-langkah untuk melindungi diri, serta membantu orang tua dalam membimbing anak-anak terkait keamanan pribadi.
OPTIMALISASI STRATEGI UPSCALING UMKM SENTRA OLAHAN KEDELAI DI BANDUNGAN, KABUPATEN SEMARANG
Authors: Sunyoto Sunyoto , Rohman Shohihatur , Rachmadi Moch Faizal , Anisykurlillah Indah
Published: December 2024

Usaha Mikro, Kecil dan Menengah (UMKM) mempunyai kontribusi yang sangat signifikan dalam perekonomian nasional. UMKM dengan ketangguhan yang ada mampu menjadi buffer dan bersifat resilien (kuat dan tangguh). Pengembangan UMKM dapat mengoptimalkan berbagai sumber daya yang melimpah di Indonesia mulai dari sektor pangan, kerajinan, logam, kearifan lokal dan sebagainya. Oleh karena itu, diperlukan sinergitas dan kolaborasi berbagai pihak dalam pengembangan UMKM agar dapat upscaling pada berbagai sektor di tingkat pasar global. Kegiatan pengabdian kepada masyarakat ini dilaksanakan dengan tujuan menyelesaikan permasalahan yang dihadapi oleh industri kecil pembuatan tahu khas Bandungan, Kabupaten Semarang, Jawa Tengah. Adapun mitra kegiatan pengabdian adalah UMKM Tahu Khas Bandungan atau Tahu Serasi “Lestari” dengan alamat Desa Kenteng RT 07/RW 01, Kecamatan Bandungan, Kabupaten Semarang, Jawa Tengah. Terdapat dua aspek permasalahan yang akan ditangani, yaitu aspek produksi dan aspek manajemen. Dalam pelaksanaan dipakai beberapa metode yang saling mendukung, antara lain dengan penyuluhan, demonstrasi, praktik langsung dan pendampingan. Dalam pembuatan mesin/alat yang akan diterapkan di mitra akan dilaksanakan di workshop jurusan Teknik Mesin FT Unnes, dengan melibatkan teknisi dan mahasiswa. Hasil kegiatan pengabdian ini adalah dihasilkannya Teknologi Tepat Guna (TTG) berupa 1 unit alat press tahu mekanis, pendampingan pembukuan dan manajemen usaha, peningkatan promosi, produksi, pemasaran dan produktivitas usaha berbasis optimalisasi kompetensi Sumber Daya Manusia (SDM).
Hubungan Hukum Kemitraan antara Driver Online dengan Penyedia Layanan
Authors: Cahyono Anton , Kusuma Indra Fredika , Kusumo Hendro Haryo
Published: December 2024

This study aims to find the best way out to realize legal protection for Online Drivers. This study uses a normative legal research type.(legal research, rechtsonderzoek),by emphasizing the implementation of law and conceptual approaches, especially related to partnership agreements. This study is not intended to verify the hypothesis testing. Thus, legal research is not known for hypotheses, and also does not recognize the term data. In legal research, the term legal material is used. The results of this study indicate that there are fundamental differences between partnership agreements and work agreements. Moreover,The partnership relationship between online drivers and application service providers is basically unique, considering that the legal and formal positions of the parties are equal (see Article 36).Law Number 20 of 2008).However, socially and economically online drivers are in a weak position. Therefore, the government as the sovereign should provide legal protection for online drivers in the form of laws and public policies. Legal protection for online drivers is basically intended to protect their rights. This is in line with John Rawls' principle of distributive justice.
Pelatihan Aplikasi Mendeley dan PoP Bagi Mahasiswa Jurusan Keperawatan
Authors: . Reny Sulistyowati , Ratih Wira Putri Fitri Yani Fina , Christyanni Yuyun , Datak Gad , Inung Sylvia Ester
Published: December 2024

Seiring dengan tuntutan di era digital sekarang untuk menyelesaikan menulis tugas akhir, mahasiswa juga dituntut untuk menggunakan aplikasi pendukung dalam menulis seperti aplikasi Mendeley dan Publish or Perish (PoP).  Aplikasi Mendeley salah satunya membantu mahasiswa dalam membuat sitasi dan membuat daftar pustaka secara berurutan.  Begitu pula dengan aplikasi PoP yang dapat membantu mahasiswa untuk mencari dan membantu menyeleksi artikel-artikel di database online.  Tujuan utama kegiatan pengabmas ini adalah untuk melatih dan mengajarkan mahasiswa semester akhir Prodi Sarjana Terapan Keperawatan Poltekkes Palangka Raya bagaimana cara mengaplikasikan Mendeley dan PoP secara intensif untuk membantu dalam mengerjakan tugas akhir berupa skripsi.  Kegiatan pengabmas dilaksanakan selama dua hari kepada 40 orang mahasiswa, hari pertama diawali dengan pre-test dan pemberian materi dan pendampingan download aplikasi Mendeley dan PoP dan hari kedua demonstrasi dan praktik mandiri serta diakhiri dengan post-test.  Mahasiswa juga diberikan tugas praktik secara langsung cara menggunakan aplikasi Mendeley dan PoP di laptop masing-masing dan dilakukan diskusi tanya jawab jika ada kesulitan.  Hasil yang didapat adanya peningkatan pengetahuan dengan nilai rata-rata pre-test 41 sebesar dan nilai post-test sebesar 82 serta mahasiswa juga bisa mengaplikasikan Mendeley dan PoP dalam menulis artikel ilmiah.
Peningkatan Kompetensi Literasi melalui Pelatihan Metode Read Aloud pada Kelompok Kerja Guru ( KKG) RA Kecamatan Karanganyar
Authors: Prihartanti Nanik , Syahida Aruny Amalia , Pusporani Mina , Sukesi
Published: December 2024

Pengabdian kepada masyarakat ini bertujuan untuk meningkatkan Gerakan literasi Sekolah dengan meningkatkan pengetahuan dan ketrampilan Guru  RA (Raudhatul Athfal) melalui pelaksanaan Sosialisasi dan pelatihan Metode read aloud  pada guru guru RA KKG Al Ikhlas I kecamatan Karanganyar. Pelaksanaan Sosialisasi dan pelatihan berupa penyampaian materi dan praktek membaca dengan nyaring (read aloud) dan dilanjutkan monitoring praktek read aloud di sekolah masing masing. Sosialisasi dan Pelatihan ini dilaksanakan secara luring pada tanggal 24 Mei 2022. Peserta yang mengikuti pelatihan yaitu 43 orang guru RA dari 9 Sekolah RA di Kecamatan Karanganyar. Sebelum pelatihan, peserta pelatihan diberikan lembar angket survey awal sebagai bahan analisis situasi. kemudian pada sesi pelatihan, peserta praktek read aloud secara berpasangan menggunakan buku cerita anak yang telah dibagikan. Setelah selesai pelatihan, peserta diminta mengisi lembar angket yang sama untuk mengetahui perubahan yang terjadi setelah pelatihan.  Hasil penilaian Guru RA sesudah diterapkan pelatihan read aloud lebih tinggi dibandingkan dengan hasil penilaian Guru RA sebelum diterapkan pelatihan read aloud. yang membuktikan bahwa pelatihan ini efektif meningkatkan pengetahuan para guru RA tentang read aloud.  Setelah kegiatan pelatihan selesai, dilanjutkan kegiatan monitoring selama 2 pekan dan dilaksanakan secara offline dan online di semua Lembaga RA yang tergabung dalam KKG Al Ikhlas I Kecamatan Karanganyar. Dan hasilnya para guru RA di kecamatan karanganyar mulai melakukan pembiasaan baik di sekolah mereka yakni membacakan buku cerita pada murid muridnya dengan teknik read aloud yang baik dan benar.
From Automation to Autonomy: Human Machine Relations in the Age of Artificial Intelligence
Authors: Thimm Caja , Gramelsberger Gabriele , Mayer Maximilian , Piller Frank
Published: December 2024

The shift from automation to autonomy marks a new chapter in human-machine relations, especially in the context of the expanding and diversifying applications of Artificial Intelligence (AI). As machines gain capabilities that resemble autonomous agency, the boundary between human and machine autonomy blurs, challenging traditional concepts of agency, control, and independence. This special issue examines the multidisciplinary perspectives on autonomy in the digital age, addressing the complexities of attributing autonomy to machines and AI systems. Philosophical, sociological, and technical approaches converge to explore how emerging forms of machine autonomy impacts human agency, freedom, and decision-making, with applications spanning from autonomous vehicles to digital assistants and military drones. Central to this discourse is the growing tension between viewing autonomy as a positive attribute and the concerns about diminishing human authority in the face of increasingly independent technologies. By framing autonomy as a gradual, relational, and attributional concept, the essays of this special issue aim to foster an integrated understanding of autonomy as both an individual and collective construct, reflecting the highly complex and quickly evolving nature of current societal, ethical, and technological challenges. Through contributions from diverse fields, the issue offers theoretical insights and empirical findings to better understand how AI systems reshape human-machine interactions and redefine autonomy within modern sociotechnical landscapes.
Rethinking Autonomy In The Digital Age: Between Human Exceptionalism, Hybridity And Conviviality
Authors: Hoss Anne
Published: December 2024

In the humanities and social sciences, there is a long tradition of discourses on the relationship between automats and human autonomy. Socio-technological transformation processes of the past decades have revitalized related discussions. At the same time, based on ideas of either human exceptionalism or hybridity, current debates tend to focus on ontological questions and comparisons between humans and machines. This paper aims to widen recent discursive foci by introducing Ivan Illich’s work which highlights institutions, power structures, and the social shaping of technology as key factors of humanartifact relations and autonomous action. It will be argued that Illich’s approach contributes to rethinking autonomy in the digital age by integrating issues of technology design and regulation and by providing a normative framework that allows for assessing autonomy as conviviality in sociotechnical constellations.
Human-Machine Relations and Relational Autonomy
Authors: Kempt Hendrik , Colombo Camilla , Nagel Saskia
Published: December 2024

The ever-growing use of interactive technologies and digitization processes in decision making contexts raises key challenges to the conceptualization of autonomy. Starting from the shortcomings of individualistic models, we argue that relational accounts of autonomy provide a more adequate characterization of human beings as socially embedded and integrated. By introducing a decision-theoretic framework, and further theoretical elaboration, we suggest a substantial account of relational autonomy incorporating machines and technologies within the significant relations entertained by agents. Besides optimizing decision-making performances, human-machine interactions could genuinely support and enhance individual autonomy, by fostering human connections, expanding the individual’s social context with additional perspectives, and prompting self-reflection. We conclude that, with crucial caveats, while we should not automate our relations, relational autonomy can benefit from automation and digitization elsewhere.