bluuebunny/crossref_metadata_2025 huggingface dataset:
GATA6 Suppresses Lung Adenocarcinoma Progression by Activating CFTR to Modulate Arachidonic Acid Metabolism
Authors: Lin Yong , Chen Yushan , Zhang Yi , Weng Jianming , Shen Rongqiang , Lin Yulin , Zhang Wenshan
Published: February 2024

Background:

CFTR, which belongs to the ATP-binding cassette transporter family
and whose members are always involved in cancer progression, is implicated in lung adenocarcinoma
(LUAD) progression, but the underlying mechanism remains undefined. Therefore, this
study intended to investigate how CFTR works exactly on LUAD progression.

Methods:

Bioinformatics methods were utilized to analyze GATA6 and CFTR expression in
LUAD and targeting relationship, followed by a pathway enrichment analysis of CFTR. GATA6
and CFTR expression levels were assessed by qRT-PCR. Cell viability and proliferation were
detected through MTT and colony formation assays. An arachidonic acid (AA) assay kit was utilized
to measure AA content. mRNA and protein expression levels of genes (cPLA2, COX-2,
and CYP1A1) related to the AA metabolism pathway were detected by qRT-PCR and western
blot, respectively. Moreover, the Dual-luciferase reporter gene assay and ChIP were used to verify
the binding of GATA6 and CFTR promoters.

Results:

GATA6 and CFTR were lowly expressed in LUAD, and CFTR was enriched in the AA
metabolism pathway. GATA6 activated CFTR transcription. Cellular and rescue experiments revealed
that low or high CFTR expression could foster or hamper LUAD cell viability and proliferation,
and concomitant treatment of indomethacin, an AA metabolism pathway inhibitor, mitigated
stimulation on LUAD progression by low CFTR expression. Silencing of GATA6 reversed
the suppressive impact of CFTR overexpression on LUAD progression via modulation of the
AA metabolism pathway.

Conclusion:

The activation of CFTR by GATA6 hampered LUAD progression by modulating
the AA metabolism pathway, suggesting that GATA6/CFTR axis might be a therapeutic target
for LUAD patients.
IL-33/ST2 Signaling and its Correlation with Macrophage Heterogeneity
and Clinicopathologic Features in Human Intrahepatic
Cholangiocarcinoma
Authors: Yasen Aimaiti , Yang ZhanDong , Feng Jun , Liang RunBin , Dai TianXing , Li Kai , Cai YuHong , Wang GuoYing
Published: February 2024

Background:

IL-33/ST2 signaling plays crucial roles in the development and progression
of various human malignancies. However, its significance in intrahepatic cholangiocarcinoma
(ICC) still remains unclear.

Objective:

This study aimed to investigate the expression of IL-33/ST2 signaling and its correlations
with macrophage heterogeneity and ICC patients' clinicopathologic features.

Methods:

The expression of different phenotype macrophage markers and IL-33/ST2 signalingrelated
markers was detected. The correlation between L-33/ST2 signaling and different phenotype
macrophage markers as well as ICC patients' clinicopathologic data was evaluated.

Results:

Massive heterogeneous cancer cells and PAS-positive cells were observed in tumor tissues.
CD68-positive cells accumulated in tumor tissues and expression of both M1 phenotype markers
and M2 phenotype macrophage markers was higher in tumor samples than para-carcinoma samples.
However, M2 phenotype macrophages represented the dominant macrophage population in ICC
tissues. Plasma levels of IL-33, ST2, and MIF were evidently enhanced in ICC patients compared to
healthy controls. IL-33/ST2 signaling-related markers exhibited a massive increase in tumor samples
than para-carcinoma samples. IL-33 and ST2 expression in ICC tissues was positively associated
with M1 and M2 phenotype macrophages. Plasma levels of IL-33, ST2, and MIF were correlated
with the diameter of tumor lesions, lymph node metastasis, TNM stage, and tumor differentiation
degree. Multivariate analysis demonstrated IL-33 expression to exhibit a correlation with the
diameter of tumor lesions, lymph node metastasis, and TNM stage. Additionally, there was a relationship
observed between ST2, MIF expression, and diameter of tumor lesions plus TNM stage.

Conclusion:

IL-33/ST2 signaling exhibited a positive relationship with macrophage heterogeneity
in ICC tissues, and upregulated levels of IL-33, ST2, and MIF were associated with aggressive
clinicopathologic characteristics. These findings may provide promising diagnostic biomarkers and
potential therapeutic strategies for ICC patients targeting IL-33/ST2 signaling.
Vitamin B12 Protects against Genotoxicity Induced by Cisplatin
Authors: Al-Bataineh Wejdan M. , Alzoubi Karem H. , Khabour Omar F. , Mahasneh Amjad , Al Momany Enaam M.
Published: February 2024

Background:

Cisplatin is an effective synthetic chemotherapeutic drug used for cancer
treatment. Vitamin B12 has been shown to possess anti-genotoxic activity. This study aimed to investigate
the effect of vitamin B12 on chromosomal damage induced by cisplatin.

Methods:

The level of sister chromatid exchanges (SCEs) and chromosomal aberrations (CAs)
were measured in cultured human blood lymphocytes treated with cisplatin and/or vitamin B12.

Results:

The results showed a significantly elevated frequency of CAs and SCEs of cisplatin-treated
cultures compared to the control (P < 0.05). The CAs and SCEs induced by cisplatin were significantly
lowered by pretreatment of cell cultures with vitamin B12. In addition, cisplatin caused
a slight reduction in the mitotic index (MI), while vitamin B12 did not modulate the effect of cisplatin
on MI.

Conclusion:

Vitamin B12 can protect human lymphocytes against genotoxicity associated with
cisplatin.
PPT1 Promotes Growth and Inhibits Ferroptosis of Oral Squamous Cell
Carcinoma Cells
Authors: Luo Qingqiong , Hu Sheng , Tang Yijie , Yang Dandan , Chen Qilong
Published: February 2024

Background:

Oral Squamous Cell Carcinoma (OSCC) is one of the most prevalent cancers
with poor prognosis in the head and neck. Elucidating molecular mechanisms underlying
OSCC occurrence and development is important for the therapy. Dysregulated palmitoylation-related
enzymes have been reported in several cancers but OSCC.

Objective:

To explore the role of palmitoyl protein thioesterase 1 (PPT1) in OSCC.

Methods:

Differentially Expressed Genes (DEGs) and related protein-protein interaction networks
between normal oral epithelial and OSCC tissues were screened and constructed via different online
databases. Tumor samples from 70 OSCC patients were evaluated for the relationship between
PPT1 expression level and patients’clinic characteristics. The role of PPT1 in OSCC proliferation
and metastasis was studied by functional experiments, including MTT, colony formation,
EdU incorporation and transwell assays. Lentivirus-based constructs were used to manipulate the
gene expression. FerroOrange probe and malondialdehyde assay were used to determine ferroptosis.
Growth of OSCC cells in vivo was investigated by a xenograft mouse model.

Results:

A total of 555 DEGs were obtained, and topological analysis revealed that the PPT1 and
GPX4 might play critical roles in OSCC. Increased PPT1 expression was found to be correlated
with poor prognosis of OSCC patients. PPT1 effectively promoted the proliferation, migration and
invasion while inhibiting the ferroptosis of OSCC cells. PPT1 affected the expression of glutathione
peroxidase 4 (GPX4).

conclusion:

PPT1 inhibits ferroptosis and promotes the growth of OSCC cells. PPT1 may be a potential therapeutic target for OSCC.
Dating Violence, Lifestyle and Risk of Type 2 Diabetes in Mexican Women University Students
Authors: Mendoza-Catalan Geu , Pimentel-Jaimes Jose Alfredo , Orendain-Jaime Erika Nallely , Dominguez-Chavez Claudia Jennifer , Higuera-Sainz Jose Luis , Villa-Rueda Alma Angelica , Rieke-Campoy Ulises , Camargo-Bravo Adriana
Published: February 2024

Background:

Dating violence is a prevalent issue among Mexican women, as is the
incidence and prevalence of Type 2 diabetes mellitus (T2DM). The effects of dating violence
can negatively impact lifestyle and, consequently, increase the risk of T2DM.

Objective:

This study aimed to explore the influence of dating violence on lifestyle and the risk
of T2DM in women university students from Mexico.

Methods:

The study employed a cross-sectional and correlational design. The study population
consisted of women university students. The sample size included 255 participants. Women
aged 18 to 39 with current dating relationships and residency in Mexicali, Baja California, Mexico,
were included. Data collection was conducted from February to May 2023. Correlations
and multiple linear regression models were conducted.

Results:

A total of 255 women participated, with an average age of 21.6 years (SD = 3.2), and
32.2% had a history of intrafamily violence during childhood. 58.8% of the participants exhibited
some level of risk of T2DM, and 56.7% of the lifestyle was mostly categorized as poor/fair.
Detachment was the most prevalent type of dating violence, followed by coercion. Dating violence
was correlated with lifestyle (r = -.430) and the risk of T2DM (r = .321). In the multiple
linear regression model, dating violence influenced the risk of T2DM.

Conclusions:

Women who reported higher levels of dating violence have a less healthy lifestyle
and a greater risk of T2DM. It is important to consider dating violence to improve lifestyle and
prevent T2DM in Mexican women university students.
Endophytes: Untapped Source of Antifungal Agents
Authors: Kumari Sudesh , Gulia Prity , Choudhary Pooja , Sharma Namita , Dahiya Sweety , Punia Aruna , Chhillar Anil Kumar
Published: February 2024

:

Screening for novel bioactive compounds has become more critical since drugresistant
fungal infections have emerged and ethno-medicinal plants have been embarked as antifungal
agents. The emphasis on medicinal plants has recently switched to the study of endophytes
and their interactions with the host plant and screening of their antifungal activity. Endophytes
are an endosymbiotic group of microorganisms that thrive within plant tissues without causing
any symptoms or marking their presence. Endophytes have been looked into as potential resources
for producing distinctive bioactive substances. The quest for bioactive natural compounds
of endophytes isolated from higher plants is receiving a lot of interest from researchers worldwide,
as seen by the recent surge in studies and publications on antifungal potential. This review
aims to comprehend the role and applications of endophytes as a promising source of antifungal
agents and enlighten on their most common mode of action.
Rapid Determination of Diverse Ganoderic Acids in Ganoderma Using
UPLC–MS/MS
Authors: Yang Yan , Jian Yuying , Liu Bin
Published: February 2024

Background::

Ganoderma is known for its pharmaceutical, nutritional, and functional
benefits. Its primary bioactive components are ganoderic acids. However, previous quantification
methods only analyzed an individual or limited number of ganoderic acids. This study aims to develop
a reliable method for simultaneously quantifying the major ganoderic acids to enhance Ganoderma
quality control and study its active ingredients.

Methods::

We developed a rapid quality assessment method to simultaneously determine the eleven
ganoderic acids in Ganoderma using ultra-high performance liquid chromatography-tandem mass
spectrometry (UPLC-MS/MS). The sample extraction method, along with mass spectrometric detection
and chromatographic separation conditions was optimized. The separation was carried out using
the ACQUITY UPLC BEH C18 column with a gradient elution of 0.1% (v/v) formic acid in water
and acetonitrile. The mass spectrometry utilized negative mode electrospray ionization (ESI), with
quantitative analysis being carried out in the MRM mode.

Results::

The calibration curves showed good correlation coefficients (r2 > 0.998). The recovery
range was 89.1–114.0%. The intra-day and inter-day relative standard deviation (RSD) were below
6.8% (n = 6) and 8.1% (n = 6), respectively. Furthermore, the detection and quantification limits
were 0.66–6.55 μg/kg and 2.20–21.84 μg/kg, respectively. All 11 ganoderic acids in the sample solution
remained stable at room temperature for 72 hours. A total of 11 ganoderic acids were quantified
in the 13 Ganoderma samples. The levels of ganoderic acids were higher in Ganoderma lucidum than
in Ganoderma sinense.

Conclusion::

The method developed in this study can quantify ganoderic acids in Ganoderma lucidum,
thus establishing a technical foundation for evaluating the Ganoderma quality.
Evaluation of Blood Lactate among Different Player Roles: A Pilot Study
on Competitive Young Male Soccer Players
Authors: Arcone Rosaria , Montesano Pietro , Di Silvestro Maurizio , D'Errico Antonio , Meccariello Rosaria , Mazzeo Filomena
Published: February 2024

Background:

Soccer match requires anaerobic and aerobic energetic metabolism.
The aim of this pilot study was to investigate the changes in blood lactate concentration in
young male soccer players in different playing roles at different time points after the soccer
match.

Methods:

Following an initial screening of 134 young soccer athletes, 8 male athletes (average
age of 15.5 ± 5 SD) were chosen for their characteristics similar to those of competitive athletes.
Players were categorized as goalkeeper, central defender, central midfielder, and forward. Blood
lactate concentrations were determined using a portable device at different times (10 min, 5 and
16 h) after the soccer match by a maximum effort test on a treadmill. The data were analyzed by
one-way analysis of variance ANOVA, followed by Bonferroni’s post-hoc test.

Results:

The following results (mean ± SD) were obtained: VO2max (%) 60.33 ± 3.10; blood
lactate (mM) end match (10 min) 2.17 ± 0.78, post-match-early (after 5 h) 2.2 ± 0.42, postmatch-
late (16 h) 3.2 ± 0.84. ANOVA analysis indicated that the blood LA concentrations at
end-match (10 min) and post-match-early (5 h) were statistically significative lower than those
determined at post-match-late (16 h) (p < 0.05).

Conclusion:

These results suggest that aerobic mechanisms can also use LA as an energy
source, contributing to the reduction of its blood concentration. This effect can be due to reduced
maximal work during a soccer match and to the LA removal during exercise at reduced
intensity. These data can provide indications for planning suitable training strategies for young
male soccer players.
State of the Art on the Contributions and Use of Geographic Information Systems (GIS) in Epidemiology in Morocco
Authors: Haisoufi Driss , Bouaiti El arbi
Published: February 2024

Background

The Geographic Information System (GIS) plays a significant role in the healthcare information system. The use of GIS as an epidemiological research tool is very little known in Morocco. According to the Moroccan Ministry of Health's Health Plan for 2025, axis 23 aims to complete the deployment of the decision support information system through the implementation of the geographic information system with the goal of improving governance and optimizing resource allocation. This creates constraints in achieving the design of an appropriate GIS for modeling pathologies using remote sensing and spatial statistical methods. The current work aims to understand GIS and its applications in epidemiology, with a focus on the state of scientific knowledge related to GIS in epidemiological research.

Methods

A state-of-the-art review of the various uses of GIS in epidemiological research was conducted using several university databases, such as PubMed and Scopus, recent articles, and certain reference books, focusing on the following keywords: “utilization,” “GIS,” and “epidemiology,” as well as their synonyms identified by MeSH.

Results

The majority of GIS research applied to epidemiology primarily involves making observations using GIS, which are then incorporated into action plans to promote population health. Therefore, it is important to break down the aspects of GIS (Geographic Information System) usage in epidemiology into four components. These include epidemiological surveillance, determining primary healthcare needs, healthcare planning, and healthcare quality.

Conclusion

These results clearly demonstrate the significant contribution of GIS to the improvement of public health. However, there is a need for positive action regarding the integration of this system, especially in developing countries.
Electrosynthesis of Sugar Derivatives
Authors: Santiago Cintia C. , Bejarano Rengel Natividad , Fernández Pablo S. , Ponzinibbio Agustin
Published: February 2024

The last decades have witnessed significant advances in the synthesis of bioactive carbohydrates.
As in all fields of organic synthesis, the search for more environmentally friendly alternative
synthetic methods is a current and expanding concern. Consequently, electrochemical organic
synthesis has emerged as an efficient and sustainable methodology. Herein, we present recent developments
in the synthesis of glycosides and other carbohydrate derivatives using electrochemical
methods. Diverse natural and synthetic O-, S-, and C-glycosides were obtained using new approaches
for the electrochemical activation of sugar precursors. The reported derivatives exhibited
wide structural diversity on both the sugar moiety and the aglycone, revealing the great potential of
the electrochemical methods.
Research on Power Angle Characteristics of One-Machine Infinite-Bus
Power Systems of Mixed Gauss and Poisson Stochastic Excitation
Authors: Li Lijuan , Li Yuange , Xiao Chuang , Zheng Xinhui , Li Qing
Published: February 2024

Background:

A high percentage of renewable energy and a high percentage of power
electronic devices are connected to the power system, which leads to the diversification and
complexity of stochastic excitation, and the traditional single-excitation stochastic model is no
longer applicable.

Objective:

The study aimed to solve the problem that the high proportion of renewable energy
and the high proportion of power electronic equipment are connected to the power system, which
leads to the diversification and complexity of stochastic excitation and makes the traditional stochastic
model of single excitation no longer applicable.

Methods:

Firstly, stochastic differential equations for power systems have been modelled with
mixed Gaussian white noise and Poisson white noise excitation. Secondly, the Milstein-Euler
predictor-corrector method has been developed to solve the stochastic differential equation model
of the power system. Finally, the influence of Gauss white noise and Poisson white noise on
the power system stability under different excitation intensities has been analyzed. The rationality
and correctness of the model have been verified by the simulation of a one-machine infinitebus
(OMIB) system.

Results:

The stochastic differential equation model of a power system with Gauss white noise
and Poisson white noise excitation has been established and its angle stability has been analyzed.
Increasing the Gaussian white noise and Poisson white noise excitation intensity can lead to an
increase in the fluctuation of the power angle curve, as well as an increase in the standard deviation
and expected value of the power angle mean curve, which may decrease the stability of the
power system.

Conclusion:

This study provides a reference for stochastic power systems modeling and efficient
simulation, and has important application value for power system stability assessment and
safety evaluation as well as related patent applications.
Revolutionizing Drug Delivery: The Potential of PLGA Nanoparticles in
Nanomedicine
Authors: Singh Akanksha R. , Athawale Rajani B.
Published: February 2024

Nanomedicine is an emerging field that utilizes nanoparticles to deliver drugs and
other therapeutic agents to specific cells and tissues in the body. One of the most promising
materials for creating these nanoparticles is Poly(Lactic-co-glycolic Acid) (PLGA), which has
several unique properties that make it well-suited for biomedical applications. These
nanomedicines, made from a combination of lactic acid and glycolic acid, can deliver drugs and
other therapeutic agents directly to specific cells or tissues in the body. This allows for more
precise and targeted treatment, reducing the potential for side effects and improving the
effectiveness of the treatment. Additionally, PLGA nanomedicines are biocompatible and
biodegradable, making them an attractive option for use in a wide range of biomedical
applications to deliver a wide range of drugs, including proteins, peptides, nucleic acids, and
small molecules for various biomedical applications such as neurodegenerative, cardiovascular
diseases, inflammatory disorders, and cancer. In summary, research on PLGA nanoparticles for
biomedical applications is ongoing and has the potential to lead a new and improved treatments
for a wide range of diseases and conditions. Looking ahead, PLGA nanoparticles have the potential
to revolutionize the way we treat diseases and improve human health. As research continues
to advance, we can expect to see new and innovative uses for PLGA nanoparticles in the biomedical
field, leading to the development of more effective and targeted therapeutics. The current
review focuses on the synthesis, physicochemical properties, biodegradation properties of
PLGA, method to prepare PLGA nanoparticles and biomedical application of PLGA. It
examines the current progress and future directions for research on PLGA in drug delivery.
Increasing the Role of Villages in Expanding the Reach of Education and Health Services: Case Study of Saptorenggo Village, Pakis District, Malang Regency
Authors: Budi Santoso Dwi
Published: February 2024

Desa Saptorenggo masih dihadapkan persoalan rendahnya jangkauan akses layanan pendidikan dan kesehatan. Dengan berfokus pada aspek pembiayaan, kegiatan ini bertujuan memberikan pendampingan kepada perangkat Desa Saptorenggo dalam: i) peningkatan ketepatan penentuan prioritas program yang dibiayai melalui APBDes; dan ii) peningkatan kemampuan memperoleh sumber pembiayaan alternatif yang berasal dari Dana Corporate Social Responsibility (CSR) dan Dana Sosial. Untuk mencapai tujuan kegiatan, peneliti menggunakan metode participatory rural appraisal (PRA). Dalam kegiatan ini, peningkatan ketepatan penentuan prioritas program pendidikan dan kesehatan melalui APBDes dilakukan dengan memetakan program yang selaras dengan fokus pembangunan nasional (cross-cutting issues) dan pemutakhiran basis data kependudukan yang dijadikan sebagai dasar penentuan kelompok penerima manfaat. Sedangkan, peningkatan kemampuan memperoleh sumber pembiayaan alternatif dilakukan dengan mengidentifikasi program pendidikan dan kesehatan yang sesuai dengan kepentingan perusahaan dan NGO.
Analysis of Solid and Liquid Waste Characteristics of Tofu Industry in Bancar Village, Bungkal District, Ponorogo Regency
Authors: Harun Mohamad
Published: February 2024

Job satisfaction is important for workers, which can encourage them to work better. The factor that influences worker satisfaction is leadership because it can create good working relationships so that it will have an impact on performance. This study aims to analyze worker satisfaction with the foreman's leadership style in building construction work and determine what attributes need to be maintained and improved to achieve a good level of satisfaction for building construction workers. The method for analyzing worker satisfaction uses Importance Performance Analysis (IPA IPA) to determine worker satisfaction by measuring the importance and implementation level. The results showed that the respondent's conformity level was 87%, meaning the workers were satisfied with the foreman's leadership. The attributes that must be maintained to increase worker satisfaction are: (1) leaders always have good relations outside the work environment, (2) leaders are always careful in accepting and hiring workers, and (3) being consistent in what is said with what is done. The attributes that must be prioritized to increase worker satisfaction are (1) leaders always serve workers well in the work environment, (2) leaders can control themselves if there are problems and encourage positive development, (3) be consistent in what is said with what is done and (4) always paying attention to the gains and losses in work.
The Socialization Of Terrorism In Canada
Authors: Gilmour John
Published: February 2024

The academic and institutional battlefield is littered with the best intentions of those attempting to bring a universally recognized definition to the term ‘terrorism’.  The concept of ‘where you sit is where you stand’ certainly applies to such endeavors.  In addition to considering how best to integrate such fundamental questions as who, what, where, why and how in a definition of the term, attempts have been confounded and complicated by where definitional efforts have been centered within a particular community. Do you adopt a social science or quasi-scientific approach?  From a jurisprudence and law enforcement perspective? Terrorist financing? Intent and motivation? Psychological drivers and personal profiles of individual terrorists? Organizational structures?  Cultural and anthropological approaches? Rationality and mental health? Historical considerations? Critical study interpretations?  All this has made for terrorism being a contested concept over the decades. As observed by Schmid and Jongman, and as we shall explore, “The nature of terrorism is not inherent in the violent act itself. One and the same act can be terrorist or not, depending on the intention and circumstances.”  But how terrorism is defined by whatever community is not a trivial issue. Definitions carry political and policy consequences that govern the counterterrorism space and how threats and risks are articulated going forward.  How the threat environment endures is often just as much an outcome of how a state elects to respond to the threat, as it is the agenda of terrorist entities.  And terrorism charges cannot be prosecuted if there is not at least some notion of how motivations, intentions and acts are defined in statutes.
Received: 01-05-2024
Revised: 01-14-2024
THE PRIVY COUNCIL OFFICE INTELLIGENCE ANALYST COMMUNITY OF PRACTICE: MISSION, VISION, ROLE, AND PRIORITIES
Authors: Henry Hugh
Published: February 2024

On November 17, 2023, Dr. Hugh Henry presented The Privy Council Office Intelligence Analyst Community of Practice: Mission, Vision, Role and Priorities for this year’s West Coast Security Conference. The presentation was followed by a question-and-answer period with questions from the audience and CASIS Vancouver executives. The key points discussed were the composition and goals of the Intelligence Analyst Community of Practice (IACOP); the four pillars of IACOP: training and tradecraft, excellence, human resources and career development, and equity, diversity and inclusion; and the next steps of IACOP to address these pillars through the development and implementation of programs and initiatives.

 

Received: 01-16-2024

Revised: 01-29-2024
Dilemas de la traducción. La Ilustración y Isabelle de Charrière
Authors: Garcia Martinez Aurora Maria
Published: February 2024

Isabelle de Charrière, autora del siglo XVIII de géneros diversos, defensora de la mujer, reflejó en sus obras las costumbres y vivencias de su época. Su obra ha sido traducida en diferentes idiomas, pero no así en español. Por ello, en mi tesis se propuso la traducción de parte de Caliste, ou Continuation de ‘Lettres Écrites de Lausanne’ (1787). Mostrar el proceso traductológico realizado, los interrogantes planteados frente a los giros estilísticos característicos de la Ilustración, los dilemas encontrados con ciertas expresiones típicas de un habla regional y las decisiones tomadas para resolverlas justificadas con ejemplos es el propósito de este artículo.
La traducción literaria como la comunicación entre culturas. Intercambio entre Chequia y México
Authors: Lochman Strnadová Karolína
Published: February 2024

El objetivo de este artículo es presentar la investigación historiográfica de las traducciones de la literatura checa al español publicadas en México, o sea, la traducción literaria de una lengua minoritaria (checo) a una lengua mayoritaria (español) como parte de la comunicación entre dos culturas (a primera vista) lejanas. En la primera parte, se explican bases teóricas y métodos empleados para el estudio historiográfico de las traducciones literarias basado en la búsqueda bibliográfica y análisis paratextual. Los resultados se presentan en dos secciones, primero, en forma de fragmentos de entrevistas con los traductores de los libros que forman parte de nuestro corpus. Esta fuente testimonial sirve para la posterior reflexión acerca de las cuestiones referentes a la sociología de la producción de la traducción literaria en México. En la segunda parte de los resultados, se expone un panorama comparativo, tanto cuantitativo como cualitativo, de las traducciones checo-mexicanas y mexicano-checas publicadas hasta el año 2019. La finalidad es utilizar los datos obtenidos para observar el intercambio literario a través de las traducciones e identificar las particularidades de la producción de las traducciones de obras checas en México.
mHealth Apps for the Self-Management of Low Back Pain: Systematic Search in App Stores and Content Analysis
Authors: Zhou Tianyu , Salman David , McGregor Alison
Published: February 2024

Background

With the rapid development of mobile health (mHealth) technology, many health apps have been introduced to the commercial market for people with back pain conditions. However, little is known about their content, quality, approaches to care for low back pain (LBP), and associated risks of use.

Objective

The aims of this research were to (1) identify apps for the self-management of LBP currently on the market and (2) assess their quality, intervention content, theoretical approaches, and risk-related approaches.

Methods

The UK iTunes and Google Play stores were initially searched for apps related to the self-management of LBP in May 2022. A repeat search in June 2023 was conducted to ensure that any relevant new apps developed in the last year were incorporated into the review. A total of 3 keywords recommended by the Cochrane Back and Neck Group were used to search apps “low back pain,” “back pain,” and “lumbago.” The quality of the apps was assessed by using the 5-point Mobile App Rating Scale (MARS).

Results

A total of 69 apps (25 iOS and 44 Android) met the inclusion criteria. These LBP self-management apps mainly provide recommendations on muscle stretching (n=51, 73.9%), muscle strengthening (n=42, 60.9%), core stability exercises (n=32, 46.4%), yoga (n=19, 27.5%), and information about LBP mechanisms (n=17, 24.6%). Most interventions (n=14, 78%) are consistent with the recommendations in the National Institute for Health and Care Excellence (NICE) guidelines. The mean (SD) MARS overall score of included apps was 2.4 (0.44) out of a possible 5 points. The functionality dimension was associated with the highest score (3.0), whereas the engagement and information dimension resulted in the lowest score (2.1). Regarding theoretical and risk-related approaches, 18 (26.1%) of the 69 apps reported the rate of intervention progression, 11 (15.9%) reported safety checks, only 1 (1.4%) reported personalization of care, and none reported the theoretical care model or the age group targeted.

Conclusions

mHealth apps are potentially promising alternatives to help people manage their LBP; however, most of the LBP self-management apps were of poor quality and did not report the theoretical approaches to care and their associated risks. Although nearly all apps reviewed included a component of care listed in the NICE guidelines, the model of care delivery or embracement of care principles such as the application of a biopsychosocial model was unclear.
Exploring the use of virtual reality to support falls awareness education in care homes: a multi-phase feasibility study (Preprint)
Authors: Ford Claire Rachel , Hawley-Hague Helen , Boulton Elisabeth , Stanmore Emma
Published: February 2024

BACKGROUND

There is a public health need to reduce falls in older people residing in care homes, due to high associated morbidity, mortality and costs. There is a lack of research exploring effective education in falls prevention in care homes. Virtual reality education is emerging as a viable teaching strategy to improve knowledge acquisition but has not yet been applied in the social care sector. This study is the first to explore the design, and acceptability of Virtual Reality (VR) as a method of delivering training in falls prevention for staff in care homes.

OBJECTIVE

This project sought to explore care home staff perceptions of current training practices, and the feasibility of a developed VR falls awareness training proof of concept.

METHODS

A two-phase research approach was adopted, including an initial exploratory qualitative research phase (Phase I) with care staff and managers (n=37) across 10 care homes to guide the design and content of the training; followed by the development phase, and a second research phase (Phase II), a mixed methods study with care staff (n=40) exploring the feasibility of the proof-of-concept technology, and perspectives of further development needs for the VR training programme.

RESULTS

Engagement, immersion and enjoyment were key factors related to the acceptability of training methods. The care staff reported that the VR app suited their learning styles and VR was acceptable as a training method. Utilisation of a case study scenario based on a resident at risk of falls increased empathy towards residents and their risks as well as experiences. Feedback for further development included additional locations, scenarios, and interactable features.

CONCLUSIONS

Identifying a potentially engaging method of falls prevention training may influence the creation of future training programmes for care homes: to assist in increasing care staff knowledge and skills and application into practice. Additional research is required to develop the proof-of-concept into a prototype, and test usability further.
Predicting and Monitoring Symptoms in Patients Diagnosed With Depression Using Smartphone Data: Observational Study (Preprint)
Authors: Ikäheimonen Arsi , Luong Nguyen , Baryshnikov Ilya , Darst Richard , Heikkilä Roope , Holmen Joel , Martikkala Annasofia , Riihimäki Kirsi , Saleva Outi , Isometsä Erkki , Aledavood Talayeh
Published: February 2024

BACKGROUND

Clinical diagnostic assessments and the outcome monitoring of patients with depression rely predominantly on interviews by professionals and the use of self-report questionnaires. The ubiquity of smartphones and other personal consumer devices has prompted research into the potential of data collected via these devices to serve as digital behavioral markers for indicating the presence and monitoring of the outcome of depression.

OBJECTIVE

This paper explores the potential of using behavioral data collected with smartphones to detect and monitor depression symptoms in patients diagnosed with depression. Specifically, it investigates whether this data can accurately classify the presence of depression, as well as monitor the changes in depressive states over time.

METHODS

In a prospective cohort study, we collected smartphone behavioral data for up to 1 year. The study consists of observations from 164 participants, including healthy controls (n=31) and patients diagnosed with various depressive disorders: major depressive disorder (MDD; n=85), MDD with comorbid borderline personality disorder (n=27), and major depressive episodes with bipolar disorder (n=21). Data were labeled based on depression severity using 9-item Patient Health Questionnaire (PHQ-9) scores. We performed statistical analysis and used supervised machine learning on the data to classify the severity of depression and observe changes in the depression state over time.

RESULTS

Our correlation analysis revealed 32 behavioral markers associated with the changes in depressive state. Our analysis classified patients who are depressed with an accuracy of 82% (95% CI 80%-84%) and change in the presence of depression with an accuracy of 75% (95% CI 72%-76%). Notably, the most important smartphone features for classifying depression states were screen-off events, battery charge levels, communication patterns, app usage, and location data. Similarly, for predicting changes in depression state, the most important features were related to location, battery level, screen, and accelerometer data patterns.

CONCLUSIONS

The use of smartphone digital behavioral markers to supplement clinical evaluations may aid in detecting the presence and changes in severity of symptoms of depression, particularly if combined with intermittent use of self-report of symptoms.
“Boys will be boys and she was asking for it” How the Media Perpetuates Victim Blaming and the Rape Myth in Rape Cases
Authors:   Binghamton University, Cabrera Arianny
Published: February 2024

The media portrayal of rape influences how the public views, not only that specific case, but rape in general. Language that victim blames and perpetuates the rape myth is subtly, at times blatantly, used to discredit the person who should be protected. I use a 21-point system of analysis to examine three different newspaper articles of 4 national rape cases. The first 2 cases look at how a white athletic assailant is portrayed as opposed to an African American athlete. The final two cases look at how a victim that was drugged is portrayed as opposed to one who was drinking. These cases are extremely similar with concrete evidence that the assailant committed the assault, yet they were portrayed differently. In these cases, the news articles on the white assailant and the victim that was willingly drinking had more victim blame statements and rape myths added to it. Through subtle language, news media outlets have distorted rape cases to continue this societal cycle of blaming rape victims and accusing them of enjoying the attack.
Los instrumentos de medida también quieren su certificado… ¡Pero digital!
Authors: Purata Sifuentes Omar Jair , Yáñez Mendiola Javier , Foyer Gisa
Published: February 2024

Algunos de nosotros veíamos películas como Matrix y pensábamos: “¡Imagínate cuando las máquinas tomen el control del mundo!” Si bien algunas máquinas ya tienen el control de partes de nuestra vida, desde los semáforos controlando la circulación de nuestros vehículos, hasta los dispositivos móviles decidiendo los contenidos que visualizamos en las redes sociales, hay un grupo de máquinas que se estaban quedando atrás en esto de tomar el control: los instrumentos de medida. Aunque en la fábrica la botella de yogur se llena con una maquina robotizada que forma parte de un sistema complejo desde hace mucho tiempo, la balanza donde se verificaba el llenado correcto de la botella seguía estando aislada, como náufrago en el mar que es la nube de la información. Eso está cambiando ya. Los certificados de calibración digital llegaron para quedarse y habilitar a los instrumentos de medición en el juego llamado industria 4.0, 5.0 o la que siga. Pero ¿qué es un certificado de calibración? y ¿qué importancia tiene para mí? Leyendo este artículo aprenderás por qué es necesaria y en qué consiste la emisión de certificados de calibración digitales.
Métodos para evitar la evaporación de agua en reservas abiertas
Authors: Gallegos-Alvarado Diana Yamilet , Balderas-Cisneros Francisco de Jesús , Garza-Cárdenas César , Morones-Ramírez José Rubén , León-Buitimea Angel
Published: February 2024

Nuevo León, situado en una región semiseca al norte de México, enfrenta periodos de sequía recurrentes, agravados por el crecimiento poblacional. La escasez de agua se convierte en un desafío crítico para la región, ya que la dependencia de presas y reservas es afectada por factores como la radiación solar, viento, baja humedad relativa y el diseño de los embalses, contribuyendo a pérdidas significativas por evaporación. Este artículo aborda la problemática proponiendo diversos métodos para reducir las tasas de evaporación, como monocapas de alcoholes grasos, shade balls, sistemas modulares flotantes, paneles fotovoltaicos flotantes, así como coberturas flotantes y suspendidas. La implementación de estas tecnologías se examina a la luz de experiencias exitosas en otros países, destacando su potencial para optimizar la gestión del agua en Nuevo León y ofrecer soluciones sostenibles ante los desafíos climáticos y de crecimiento demográfico.
Escherichia coli: amiga y enemiga en nuestro cuerpo
Authors: Uc Cachón Andrés Humberto , Molina-Salinas Gloria María , Dzul Beh Angel de Jesús , Dzib Baak Haziel Eleazar
Published: February 2024

La infección del tracto urinario es una de las enfermedades infecciosas más frecuentes en todo el mundo y su principal agente causal es Escherichia coli. Esta bacteria es un habitante común de nuestro intestino, sin embargo, cuando llega al aparato urinario puede ocasionar este padecimiento. Para causar estas infecciones, E. coli utiliza diversos mecanismos que le permiten ascender y vivir en el aparato urinario. Afortunadamente hoy en día se cuenta con diferentes antimicrobianos para eliminar este patógeno. En este artículo conoceremos acerca de E. coli uropatógena, los mecanismos que utiliza para colonizar el tracto urinario y los antimicrobianos para combatir las infecciones por este patógeno.
¿Es posible identificar nuevos fármacos desde tu computadora?
Authors: Alvarado Parra María Teresa , Mancilla Montelongo María Gabriela , Verdel Aranda Karina
Published: February 2024

¿Cómo se obtienen los nuevos fármacos? ¿De dónde salen nuevos productos para descontaminar un lago o el suelo? Las plantas y los microorganismos producen millones de moléculas que pueden tener una de estas importantes aplicaciones biotecnológicas. Hasta hace unos años, la caracterización biotecnológica era un proceso costoso y complicado. Sin embargo, la revolución de la bioinformática trajo consigo las bases de datos biológicas que, en conjunto con el desarrollo de la tecnología, han permitido el diseño y desarrollo de algoritmos para conocer la función biológica de un compuesto. Gracias a ello, actualmente se puede predecir la actividad biológica de una gran variedad de moléculas antes de emprender un experimento en el laboratorio. El objetivo de este artículo es compartir cómo es que se pueden caracterizar productos naturales, como fármacos, desde una computadora personal, utilizando bases de datos pertinentes y métodos computacionales in silico, para después comprobar la actividad biológica con pruebas in vitro.
El sufragio de los mexicanos en el extranjero, una perspectiva jurídica
Authors: Sánchez Sánchez Alejandro , Sánchez Mendoza Daffne Cecilia
Published: February 2024

En este artículo se realiza una revisión crítica del sufragio de los mexicanos en el extranjero, desde una perspectiva jurídica, considerando que es un análisis sistemático con un tópico vinculado a la democracia. Con el análisis, se abordan temas como los antecedentes, recomendaciones internacionales a México, reformas constitucionales, el marco jurídico, antecedentes estatales y una observación específica al proceso electoral de 2012, de lo anterior, se deduce que: si los ciudadanos mexicanos que se encuentran en el extranjero no se encuentran en igualdad con los que están en el territorio nacional, porque se encuentran en una situación social diferente, estatus por el cual no pueden ser limitados a ejercer su más importante prerrogativa, que es la de votar.
La consolidación histórica de la migración irregular en Europa: leyes, políticas migratorias defectuosas
Authors: Ortega Velázquez Elisa
Published: February 2024

Este artículo analiza la consolidación histórica de la migración irregular en cinco Estados de la Unión Europea. Primero, se revisan las leyes y políticas migratorias emitidas en los Estados seleccionados, durante cuatro etapas de la historia de la migración internacional moderna. Segundo, se analiza su papel en la construcción y perpetuación de la migración irregular en estos Estados, toda vez que a lo largo del tiempo han probado ser defectuosas. Se concluye, por un lado, que estas leyes y políticas fallan en producir los resultados deseados porque han resultado en el aumento y consolidación de la migración irregular, lo cual es radicalmente opuesto a sus objetivos de control y reducción, y, por otro lado, que cierta migración irregular puede disminuirse si se subsanan las insuficiencias de las leyes y políticas nacionales de control de la migración.
The role of organizational commitment in the relationship between collaborative leadership and teacher performance
Authors: Muhammad Shohib  , Suhariadi Fendy , Agustina Tri Siwi
Published: February 2024

Teacher performance significantly determines the quality of education, and various methods are employed to enhance it. Factors influencing teacher performance include personal, organizational, and managerial aspects. This study aims to examine the role of organizational commitment in the relationship between collaborative leadership and teacher performance. Participants in this research were recruited using purposive sampling, and the criteria included permanent teachers with a minimum of 2 years of experience, totaling 195 individuals.  This correlational study utilized Leadership Scale, Organizational Commitment Scale, and Teacher Performance Scale to collect data, which were then analyzed through the Hayes Process Model 4. The findings indicate a relationship between collaborative leadership and teacher performance (r=0.759, p<.01) and organizational commitment with teacher performance (r=0.450, p<.01). Commitment serves as a mediator in the relationship between collaborative leadership and teacher performance, with an indirect effect value of 0.047, se=0.018, cl (0.015 – 0.089), confirming all hypotheses in this study. The study shows that teacher performance is influenced by the collaborative leadership style of the school principal mediated by the organizational commitment of the teachers.  To enhance teacher performance, school principals can employ a collaborative leadership model and strengthen organizational commitment.
Acolhimento da mulher migrante venezuelana na atenção básica
Authors: Ana Beatriz Oliveira Costa  , Gleidilene Freitas da Silva  , Barbara Almeida Soares Dias  , Silva Paulo Sérgio da Silva
Published: February 2024

Introdução:  O presente ensaio emerge a partir de uma aposta científica que se propõe a produzir reflexões teorizadas sobre as práticas assistenciais de acolhimento produzidas pelos profissionais da saúde com mulheres migrantes venezuelanas na atenção básica. Objetivo: Refletir sobre o acolhimento a mulher migrante venezuelana na atenção básica. Material e Métodos: Trata-se de um ensaio teórico-reflexivo. Salienta-se que neste tipo de estudo a produção de reflexões corre pela compreensão de um dado objeto sem que nele haja um sistema de compreensão rígido. Resultados: As reflexões foram agrupadas em um núcleo teórico-reflexivo, intitulado: fundamentos para pensar o acolhimento a mulher migrante venezuelana na atenção básica. Nele são encontrados conceitos e reflexões que tocam atenção básica, migração, processos migratórios envolvendo mulheres venezuelanas e estratégias de acolhimento as suas necessidades em unidades básicas de saúde. Conclusão: As (in)conclusões reflexivas para intensificar investigações perpassam por leituras do cotidiano no trabalho em saúde. Nesse sentido, é fundamental observar três rotas conceituais e reflexivas que fundamentalmente são necessárias para cuidar da mulher migrante venezuelana de forma acolhedora na atenção básica, a saber: escuta qualificada, vínculo e clínica ampliada do sujeito; como forma de promover uma assistência alinhada aos princípios e diretrizes da política nacional de humanização.