bluuebunny/crossref_metadata_2025 huggingface dataset:
The Role of Boron Nitride Particles on Thermal Conductivity, Transverse Strength and Surface Hardness of Heat Cure Acrylic Resin
Authors: Ali M. Hussein Hussein , J. Al-Judy Hikmat
Published: January 2024

Objectives: The objective of this research was to investigate how boron nitride powder addition in percentages of 1% weight and 1.5% weight, affected the thermal conductivity, transverse strength, and surface hardness of heat cured acrylic resin denture base material. Methods: Ninety specimens were made from heat-cured acrylic resin and then divided into three groups based on the tests: a control group, a reinforced poly methyl methacrylate group with 1% weight boron nitride particles, and a reinforced poly methyl methacrylate group with 1.5% weight boron nitride particles. They investigated into the thermal conductivity, transverse strength, and surface hardness tests. Results: This research showed that 1% and 1.5% weight boron nitride particles significantly increased thermal conductivity and surface hardness in comparison to the controlled group. There was a highly significant increase in transverse strength compared to the control group; at the concentration of 1% weight boron nitride particles. Conclusion: Boron nitride particles enhance the thermal conductivity, transverse strength, and surface hardness when added to heat cure acrylic resin denture base material.
Effect of Beverage Solutions on Surface Roughness of PEEK CAD –CAM, 3D Printing Denture Base and Heat Cure Acrylic Resin Denture Base Materials
Authors: Muwafaq Fadhil Noor , Zuhair Mohammed Nada
Published: January 2024

The Aim: The aim of this research was to investigate how distilled water, tea, coffee, and cola affected the surface roughness of poly ether ether ketone CAD-CAM, 3D printing, and heat cure acrylic resin denture bases at specific intervals (6 ,12days). Materials and Methods: Disk shape 10 mm (diameter) ×2 m m (thickness), manufactured from materials used which were PEEK, 3D printing and heat cure acrylic resin. Total number of samples are n= (75) samples, control samples not immersed in beverage media n= 15, experimental samples immersed in beverage solutions (distilled water, tea, coffee and cola) n=60 for evaluating the surface roughness at (6, 12 and 24 days) .Then all collecting data were statically analyzed by spss v ersion 25, by means of descriptive statistics, analysis of variance (ANOVA) and duncan multiple range tests at p ≤ 0.05. The Results: The results revealed a significant increase in surface roughness in all beverage solutions at p ≤ 0.0 5. Conclusions: All beverage solutions had a negative effect on surface roughness of all experimental materials, the surface roughness increased. cola had the most aggressive effect followed by coffee then tea and distilled water have the least ef fect.
Effect of Heat Treatment Duration and Cooling Conditions on Flexural Strength and Surface Roughness of Cobalt-Chromium Alloys produced by Selective-Laser-Melting
Authors: Nashwan Almulayounis Mohammed , Asim Ali Ahmed
Published: January 2024

Post-heat treatment may enhance mechanical properties of selective laser melting (SLM) Cobalt chromium (Co-Cr) alloys, however it is unknown what duration the heat treatment needs to last and how the rate of cooling impacts the alloy's flexural strength and surface roughness. In this study, SLM Co-Cr alloy specimens were heated at 1150 C for 1 or 6 hours and subsequently cooled by air cooling (AC), furnace cooling (FC), or water quenching (WC). Flexural strength and surface roughness were then tested. Aim of this study: Investigate the effect of heat treatment and different cooling conditions on the flexural strength and surface roughness of SLM Co-Cr alloy specimens. The heat treatment will be conducted at 1150 C for two different durations (1-hour and 6-hours) and under three cooling conditions (AC, FC, and WC). Materials and methods: A total of forty-two rectangular specimens, measuring (34×13×1.5 mm) were manufactured through SLM and divided into seven groups, six specimens for each group as follows: The first group denoted as control with no heat treatment and no cooling applied, second and third groups heated for 1 or 6 hours then cooled in the air (AH-1 and AH-6), fourth and fifth groups heated for 1 or 6 hours and left inside the furnace until they cooled (FH-1 and FH-6), sixth and seventh groups heated for 1 or 6 hours and cooled by water quenching (WH-1 and WH-6). Flexural strength and surface roughness tests were performed on the specimens. A flexural strength value of (2147.33 MPa) was indicated that the control group exhibited the highest flexural strength, whereas the FH-6 group exhibited the lowest flexural strength value (1282.66 MPa). The control group showed the worst surface roughness (1.63 μm) while all other groups demonstrated no significant differences in surface roughness ranging from (0.32 to 0.49 μm) with a slight increase in the 6-hours heated groups. Conclusions: Slow cooling rate inside the furnace affects flexural strength negatively. Therefore, a high cooling rate is recommended to get a better flexural strength. On the other hand, surface roughness results suggests that 1-hour is better than 6-hours in terms of heat treatment duration and time saving
IMPLEMENTASI E-LEARNING DALAM PEMBELAJARAN BAHASA INDONESIA DAN LITERASI DIGITAL
Authors: Dewi Ria Candra
Published: January 2024

ABSTRAK: Penelitian ini bertujuan untuk mengidentifikasi Implementasi E-Learning dalam pembelajaran Bahasa Indonesia dan Literasi Digital.    Metode deskriptif analisis adalah metode atau pendekatan pemecahan masalah yang melibatkan penggambaran, penerangan, klarifikasi, dan penilaian keadaan dan keadaan suatu objek masalah dari sudut pandang penulis berdasarkan temuan penelitian kepustakaan (literature review) yang memberikan dukungan. Pemanfaatan e-learning dalam literasi digital dan pembelajaran bahasa Indonesia menjadi fokus permasalahan. Hasilnya menunjukkan betapa efektifnya penggunaan e-learning dalam mengajarkan literasi digital dan bahasa Indonesia kepada siswa karena dapat menyederhanakan berbagai hal bagi mereka.

KATA KUNCI: Implementasi E- Learning, Pembelajaran Bahasa Indonesia, Literasi Digital

 

IMPLEMENTATION OF E-LEARNING IN INDONESIAN LANGUAGE LEARNING AND DIGITAL LITERACY

 

ABSTRACT: This study aims to identify the Implementation of E-Learning in Indonesian learning and Digital Literacy.    The descriptive method of analysis is a problem-solving method or approach that involves describing, enlightening, clarifying, and assessing the state and state of a problem object from the author's point of view based on the findings of literature review research that provides support. The use of e-learning in digital literacy and learning Indonesian the focus of the problem. The results show how effective the use of e-learning is in teaching digital literacy and Indonesian to students because it can simplify things for them.

KEYWORDS: E-Learning Implementation, Indonesian Learning, Digital Literacy
Development of a Mini-research-based Digital Module Using Sigil in Endocrinology Learning
Authors: Rahma Widiantie  , Ina Setiawati  , Anna Fitri Hindriana  , Edi Junaedi  , Elsa Chintya
Published: January 2024

Developing technology-based teaching materials that are more innovative, creative, effective, efficient and contextual is a demand in learning. Lecturers are required to be able to develop media and teaching materials by utilizing technological advances. The aim of this research is to develop complete teaching materials or modules consisting of materials, student worksheets, evaluations, assessment techniques and learning videos to improve students' mastery of concepts using the sigil application. The characteristics of the module developed is a digital module based on mini research, where mini research learning can improve students’, problem solving abilities and integrated science process skills. The method in this research is the Design and Development Research method with the PPE model which includes 3 stages: Planning, Production, and Evaluation. The results of the research are digital modules based on mini PPE research models, planning by analyzing the need to design flowcharts and story boards from digital modules, production by creating digital modules, namely compiling the module framework and endocrinology material in Microsoft Word software (html format) the file is opened in the software sigil editor is saved in epub format, evaluation by material experts and media experts by assessing the feasibility of the digital sigil module based on mini research in endocrinology learning. The results of the validity test based on the appropriate aspects of content, language and presentation are valid. The results of the practicality test by students on the aspects of content, language and usefulness are valid. Mini-research-based digital modules using sigil software are valid, practical and suitable for use in Endocrinology courses with the advantage of facilitating thinking skills and increasing student learning independence.
Effect of Problem-Based Learning Integrated with Ethnoscience on Critical Thinking Skills in SMA Negeri 01 Kubu
Authors: Mitha Gita Isvida  , Ari Sunandar  , Hanum Mukti Rahayu
Published: January 2024

This research was motivated by the low critical thinking skills of students at SMAN 01 Kubu. The aim of this research is to determine the effect of the model problem-based learning integrated Ethnic on students' critical thinking skills. Sampling uses statistical tests and Effect size. The research sample was students of classes X Mia 1 and X Mia 2 at SMAN 01 Kubu. Data collection uses the Essay test method which refers to Fascione's theory. Based on the research results obtained in the experimental class, the score for the synthesis skills indicator was 71.42%, problem recognition and solving skills 74.28%, evaluation or judging skills 51.42%, analysis skills 80%, and concluding skills 60%. In the control class, scores were for synthesis skills 54.28%, problem recognition and solving skills 14.28%, evaluation or judgment skills 22.85%, analysis skills 60%, and concluding skills 40%. In calculating the effect size, a value of 1.54 was obtained, which is in the very high category.
Selection of Proteolytic Bacteria from Bonoloyo Public Burial Place (PBP), Banjarsari, Surakarta, Central Java
Authors: Putri Salwa Salsabilla  , Yasir Sidiq  , Erma Musbita Tyastuti  , Triastuti Rahayu
Published: January 2024

Public Burial Place (PBP) is a cemetery for everyone. In PBP, protein decomposition occurs actively because the human body is made up of 16.4% protein, so it is most likely that proteolytic bacteria can be found. Previous research has isolated as many as 45 isolates from PBP Bonoloyo, Surakarta, but has not selected their proteolytic capabilities. The aim of the study was to isolate proteolytic bacteria from the Bonoloyo Public Cemetery and identify them. The bacterial isolate of PBP Bonoloyo is a collection from the FKIP Biological Laboratory of Muhammadiyah University of Surakarta that selected its proteolytic capabilities using the milk agar scheme (SMA). The parameters measured are the diameter of the colony and the lymphatic zone formed to obtain the value of the proteolytic index (IP). For bacterial isolates showing a positive proteolytic activity, simple identification is carried out through the observation of colonial morphology and Gramme colouring. The results of the study showed that as many as 28 isolates (62.2%) were positive for proteolytic activity, with IP values >2 for B1 and B3. Bacterial proteolytic isolates are dominantly white to yellow with irregular, filamentary, spindle, and circular colonial forms. The results of Gramme colouring show that bacterial isolates that have proteolytic abilities are a group of Gramme negative bacteria that are basil shaped. The bacterial isolate that shows the highest IP value is the B1 isolate, which is suspected to be of the genus Bacillus. This research obtained data showing that in the public cemetery (PBP), Bonoloyo stores potential as a proteolytic bacterial habitat for a group of Gramme negative bacteria.
The Effect of Thiamine HCL Concentration Variation on the Seedling of Phalaenopsis Var. Happy Valentine
Authors: Handini  , M. Anas Dzakiy  , Eny Hartadiyati
Published: January 2024

Phalaenopsis var. Happy Valentine orchid is a plant with a growth and flowering process of approximately 1-2 years. Generally, orchids can bloom in about 9-12 months. Optimal concentrations of Thiamine HCl (vitamin B1) are required to support the vegetative growth of Phalaenopsis var. Happy orchids. This research aims to determine the effect and the best concentration of vitamin B1 among 1ml, 2ml, and 3ml on the vegetative growth, including leaf span, root quantity, leaf width, and length of young leaves of Phalaenopsis var. Happy Valentine seedlings. The method used was a Completely Randomized Design (CRD), with treatment factors being the concentration of vitamin B1 and Growmore fertilizer, comprising four treatment levels and six replications, namely V0 = 2gr/L Growmore fertilizer, V1 = 2gr/L Growmore fertilizer + 1ml B1, V2 = 2gr/L Growmore fertilizer + 2ml B1, dan V3 = 2gr/L Growmore fertilizer + 3ml B1. This research used 24 Phalaenopsis var. Happy Valentine orchid seedlings as research samples. The data were analyzed using ANOVA with a significance level 0.05 and subsequently subjected to Duncan's test. The results indicate that vitamin B1 significantly affects leaf span, length of young leaves, and the quantity of roots in Phalaenopsis var. Happy Valentine.
The role of youth organizations in solving social problems of the region
Authors: Sedykh Olga Gennadevna , Taraban Olga Vyacheslavovna
Published: January 2024

The subject of the study is the activities of youth organizations in solving social problems. The list of these key institutions includes youth public organizations, which are classified as socially oriented non-profit organizations. The relevance of this work is due to the fact that today the participation of young people in public organizations contributes to the formation and development of civil and social self-awareness, the development of special competencies and personal qualities among young people. But in addition to personal development, such associations are capable of working in solving major social problems. The directions of financing socially-oriented NPOs are analyzed. The regional features of the implementation of youth policy in the Irkutsk region are shown. The main conclusion of the study is that youth public organizations can prove themselves and show their ability to make an invaluable contribution to solving such problems. To assess the contribution of youth organizations in solving social problems, a questionnaire survey was conducted, revealing the motivational attitudes and priority areas of activity of youth participating in the activities of public organizations. Based on the results of the study, it was revealed that when interacting with the state, the non-profit sector can make an invaluable contribution to solving the social needs of residents of the region. Based on the results obtained, practical recommendations were proposed for improving the activities of youth public organizations in solving social problems.
Industrial development in Russia: the study of sectoral structure
Authors: Bryantseva Olga Sergeevna
Published: January 2024

The article deals with the issues of studying the sectoral structure of the economy of the Russian Federation and the transformation of the sectoral structure of industry. A sample of macroeconomic indicators characterizing the structure of industrial production by gross value added, the number of employed personnel, the value of exports for the period 1990-2022 was formed and analyzed. Open statistical data consolidated by the UN International Organization for Industrial Development (UNIDO) and Rosstat were used. Calculations of structural shifts in the manufacturing industry of the Russian Federation have been carried out. The article shows that the sectoral structure of the Russian economy has undergone tremendous structural transformations. During the period under review, the sectoral structure of industry in terms of gross value added was significantly transformed: the share of oil refining, chemical industry, metallurgy is increasing, while the share of machine-building and instrument-making is decreasing. In the sectoral structure of employment, the share of high-tech industries such as machine building and electronics and agriculture is decreasing, while the share of employment in trade and construction, transportation and communication is increasing. In the sectoral structure of exports, the share of manufacturing industries is decreasing and the share of extractive industries is increasing. It is concluded that for a long time the sectoral structure of the Russian economy has been under the influence of deindustrialization.
Absolute Nodal Coordinate Formulation-Based Shape-Sensing Approach for Large Deformation: Three-Dimensional Beam
Authors: Wu Maoqi , Tan Shujun , Qie Yuhang , Guo Junchao , Yang Hao , Peng Haijun
Published: January 2024

In recent years, fiber-optic shape sensing, which means reconstructing the deformation state of structures from strain information measured by fiber-optic sensors, has attracted interest from many fields. Most of the existing shape-sensing research for flexible three-dimensional (3D) slender structures is based on simple strain-curvature transformation, relying on standardized substrates with a circular cross section and particular forms of fiber layouts. To develop a more general shape-sensing method that can be applied to a wider range of practical engineering conditions, in this paper, the strain–displacement relationship of 3D slender structures under the effect of multiple deformation modes coupling is described by introducing absolute nodal coordinate formulation element, and the deformation reconstruction problem is reorganized into a nonlinear optimization problem that can be applied to large deformation and accommodates different cross-sectional shapes and optical fiber layouts. Due to the rapid increase in the calculation difficulties of nonlinear optimization problems with the number of variables, an element-by-element solving strategy is adopted, and nodal degrees of freedom that have less influence on the overall shape of the structure are merged. In addition, in order to address the issue of local strain anomalies caused by unmodeled factors such as section warping, the pointwise matching between the theoretical strains and measured strains is relaxed to an average matching in subregions to capture the overall deformation, improving the robustness and computational efficiency of the solution process. The accuracy and computational performance of the proposed method are verified through numerical simulation and experiment.
GENETIC MECHANISMS OF BACTERIAL RESISTANCE TO CIPROFLOXACIN (LITERATURE REVIEW)
Authors:   Grodno State Medical University, Grodno, Belarus, Martsulevich M. V. , Sokolova T. N. ,   Grodno State Medical University, Grodno, Belarus
Published: January 2024

Ciprofloxacin, as a member of the fluoroquinolone group, is widely used to treat diseases caused by both grampositive and gram-negative bacteria. However, in recent years there has been an increase in resistance to this drug, which may be associated with the overuse of ciprofloxacin due to its broad spectrum of action. In this regard, in order to develop new and effective drugs against drug-resistant pathogens, there is a need to study and analyze such resistance mechanisms to ciprofloxacin as modification of target molecules, changes in drug penetration and plasmid-mediated quinolone resistance. The article presents up-to-date information on genetic mechanisms of bacterial resistance to antimicrobial drugs belonging to the fluoroquinolone group.
Gender stereotypes when choosing the head of the clan in Yakut families
Authors: Cherdonov N. M. , Eliseeva N. D.
Published: January 2024

The research of gender education and gender-role behavior of men and women is becoming increasingly relevant in modern society. Psychological trends of modern society, appealing to androgynous values, increasingly blur the boundaries that define male and female roles and their functions. This is especially evident in family relationships. The article is devoted to the idea of the head of the genus in the Yakut family, gender stereotypes among the Sakha people. In the course of the study, the author’s methodology was developed based on the Mukhina’s methodology “Criminal or scientist», as well as the authors’ questionnaire on identifying the head of a clan and the line of the clan. The respondents were young people aged 18 – 29 years. The results of the study showed that in modern Yakut families, the ancestral line is more often carried out on the mother’s side. The head of a clan in most cases is also a woman. It was revealed that there are no statistically significant gender differences in our sample
Philosophical and social comprehension of labor in the creative society (in memory of the professor Tamara Mikhailovna Mikhailova)
Authors: Mikhailova A. V.
Published: January 2024

The 21st century is characterized by the development of new forms in the social aspects of labor; labor influences the formation and functioning of the development of a creative society in the digital era. Many researchers pay attention to the ideological problem caused by the development of technologies and intelligent systems in the information space, but it is important to pay attention to the societal essence of labor, since labor is not only a means and a process for obtaining material results, but also has broad social significance. Labor forms relationships that determine the social status and identity of the individual; the socio-philosophical content of labor prevents the emergence of a new phenomenon of the precariat and fills it with meaning and value. Labor in a creative society plays a role in creating and maintaining economic stability, increasing self-esteem and self-determination. The article shows the importance of addressing the topic of socio-philosophical aspects of the content of work through the prism of the life path and works of Dr. Tamara Mikhailova, Professor of the Yakutsk State University, later M. K. Ammosov North-Eastern Federal University. The article uses methods of analysis, synthesis and comparative analysis to consider the basic concepts and ideas related to the philosophy and social essence of labor. The socio-philosophical essence and function of labor in the creative economy of the 21st century requires constant scientific research, the search for new solutions to respond to trends and challenges of society, to improve the quality of human life.
Somatisms in the geographical vocabulary of the Yakut and Khakass languages
Authors: Sorova I. N. , Neustroev K. K.
Published: January 2024

Since ancient times, a person names objects of the environment, correlating them, first, with parts of his body. The study of somatisms is of great interest, since the nomination, process is particularly evident in them, the connection between the object and the person giving the name is clearly manifested: the transparency of the internal form allows us to establish the cause of their origin and identify some patterns of nomination. A comprehensive analysis of somatisms in the geographical vocabulary of the Yakut and Khakass languages, their systematization and description, in our opinion, will allow us to better understand how native speakers comprehend the surrounding reality through the medium of the human body. The need to study somatisms denoting elements of geographical objects is determined by the fact that they can provide valuable material on the lexico-semantic and structural development of lexical units of the Yakut and Khakass languages. The purpose of the work is to study the features of the functioning of somatisms in the field of geographical vocabulary of the Yakut and Khakass languages. To achieve this goal, the following tasks are solved: to consider the history of the study of somatic vocabulary in Turkic linguistics; to identify somatisms in geographical terms of the Yakut and Khakass languages by continuous sampling from lexicographic sources; classification of identified geographical terms by parts of the human body; lexico-semantic classification of identified somatisms by natural objects. To perform these tasks, such research methods as descriptive, comparative and statistical methods were used. The scientific novelty of the study consists in the study of somatisms in geographical names in the Yakut and Khakass languages in a comparative aspect. The theoretical and practical significance is determined by the possibility of using materials and research results in the study of lexical groups in the Turkic languages (and languages of other families), as well as in the development of lecture courses, conducting seminars on vocabulary.
The values of the warhorse suits and the epic tradition
Authors: Orozobekova J. K.
Published: January 2024

In the scientific article “Meanings of war horse colours and epic tradition” the typological similarities of poetic description of heroic epics of Turkic-speaking peoples and Siberia formed in the context of the epic “Manas” are considered. The etymological meanings of war horse colours in the artistic structure of the epic “Manas” are also analysed. The epic “Manas” has brought to our days a whole range of images of horses, starting with fantastic mythological images of horses and ending with realistic ones. Descriptions of the horse’s colours, the peculiarities of its walking and running, its ability to understand not only the master’s orders but also its state of mind occupy a large place in the narrative. Each horse is endowed with a nickname, each is characterised by some qualities peculiar only to it. It is known that different time layers are present in the epic, and from this it is possible to reveal the images of the Tulpar in their stadial evolution, which makes it possible to consider their essence in hyperpolarity. In the epic “Manas” there are more than 150 names of war horses of different colours. The totality of artistic images of war horses depicted in the context of “myth and reality” as endowing them with wings, human speech, and the ability to transform through transformation into werewolves is a real cultural treasure of the epics and a subject of scientific interest of hundreds of researchers. In the process of evolution each national epic preserving the given properties of the archetype, at the same time transformed into the poetic image of horses some specific properties, developing and glorifying some special qualities inherent only to the given epic.
The Year in Hungarian Cardiology 2022: Cardiac Imaging
Authors: Pálinkás Attila , Szilveszter Bálint , Ágoston Gergely , Dohy Zsófia , Pálinkás Eszter Dalma , Vágó Hajnalka
Published: January 2024

In 2022, the Hungarian Cardiovascular Imaging community contributed to several scientifi c papers that were published in international journals. Clinical research activities employed novel echocardiographic methods including two- and three-dimensional, strain and tissue Doppler imaging of all cardiac chambers. These echocardiographic modalities were applied in diff erent patient populations such as patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or post-SARS-CoV-2 aff ected individuals, athletes, patients with systemic autoimmune diseases, cardiomyopathies, hematologic diseases, metabolic diseases, congenital heart disease or valvular interventions. Beyond resting echocardiography, original research results revealed important information in the fi eld of exercise stress echocardiography as well. Hungarian studies using cardiac magnetic resonance imaging evaluated patients with diff erent pathologies such as cardiac amyloidosis, cardiomyopathies, myocarditis due to SARS-CoV-2 vaccinations, and athletes in post-SARS-CoV-2 states. Hungarian research activities in the fi eld of cardiac computed tomographic imaging covered the evaluation of moderate coronary lesions, correlates of myocardial ischemia, coronary plaques, coronary calcium, recurrence of atrial fi brillation after radiofrequency ablation and morphological changes after valvular interventions. Novel technologies have been applied in cardiac computed tomographic imaging by Hungarian researchers, with higher spatial resolution and enhanced spectral capabilities in coronary artery assessment.
Láthatatlan (EKG) nyomon: kardiogén, neurogén vagy iatrogén syncope?
Authors: Gausz Flóra , Pap Róbert , Benák Attila , Miklós Márton , Horváth Zoltán , Irsai Ákos , Bencsik Gábor , Makai Attila , Sághy László , Vámos Máté
Published: January 2024

Ismeretlen eredetű eszméletvesztés esetén nehézséget jelenthet a kardiológiai és a neurológiai etiológia elkülönítése. Egy 44 éves nőbeteg esetét mutatjuk be, akinek anamnézisében 10 éves különbséggel 2 éjszakai konvulzív rosszullét szerepelt. Alapellátásában végzett 24 órás Holter-EKG-n rövid, polimorf, nem tartós kamrai tachycard epizódok kerültek leírásra, amelyek alapján családorvosa – kardiogén eredetet feltételezve – a beteget közvetlenül elektrofi ziológiai felvételre referálta. A beteg felvételekor levetiracetám és lamotrigin terápiában részesült. A rosszullétek hátterében felmerült az epileptogén eredet és a kardiogén syncope lehetősége is, valamint a lamotrigin proaritmiás hatása. Az elvégzett neurológiai vizsgálatok alapján az epilepszia fennállása nem tűnt valószínűnek, de azt biztosan kizárni sem lehetett. A kardiológiai képalkotó vizsgálatok strukturális vagy miokardiális eltérést kizártak. Ergometria során monomorf, néha kapcsolt formában is megjelenő kamrai extrasystolia volt provokálható. Irodalmi adatok alapján felvetődött a lamotrigin nátriumcsatorna-betegséget demaszkírozó hatása is, így ajmalintesztet végeztünk, amely során 1-es típusú Brugada-jel, illetve kamrai extraütések és polimorf nem tartós kamrai tachycard epizódok jelentek meg. Tekintettel a típusos éjszakai agonális légzésre és az indukálható EKG-eltérésekre, Brugada-szindróma diagnózisa alapján, subcutan-ICD-beültetést végeztünk.
Nagy intenzitású rosuvastatin vagy rosuvastatin/ezetimib kombinációs lipidcsökkentő terápia hatékonysága hypercholesterinaemiás, igen nagy kardiovaszkuláris rizikójú magyar betegekben – a 3T-FIGHT-vizsgálat első eredményei
Authors: Reiber István , Márk László , Együd Ferenc , Mező Izabella , Császár Albert
Published: January 2024

Célkitűzés: A 2019-es ESC/EAS-ajánlás előtt tervezett és engedélyezett prospektív, obszervációs vizsgálatunk elsődleges célkitűzése az volt, hogy igen nagy kardiovaszkuláris kockázatú, 1,8 mmol/l feletti LDL-C-szintű betegekben nagy intenzitású rosuvastatin vagy rosuvastatin/ezetimib kombinációs lipidcsökkentő terápiával 6 hónap alatt minél nagyobb arányban érjük el az 1,8 mmol/l alatti célértéket és a legalább 50%-os LDL-C-csökkenést. Betegek: A vizsgálat 2020–2021-ben a COVID-19-járvány különböző hullámai idején 150 családorvosi és 60 szakorvosi rendelés betegein folyt. Munkánkban 3017 fő 6 hónapos terápiájának hatásosságát elemezzük, a betegek 47%-a nő volt, 55,5% kardiovaszkuláris, 35,6% cerebrovaszkuláris, 20,4% perifériás érbetegségben szenvedett. Eredmények: A 6. hónapban a résztvevők 20,5%-a kapott rosuvastatin-monoterápiát, és 63,7%-a szedett fi x dózisú rosuvastatin/ezetimib készítményt. A monoterápiát kapók 37%-a és a fi x kombinációt szedők 52%-a érte el az 1,8 mmol/l alatti LDL-C-szintet. Az 1,4 mmol/l alatti LDL-C-szintet statin-monoterápiával 11%-ban, míg fi x statin/ezetimib kombinációval 22%-ban sikerült elérni. A legalább 50%-os LDL-C-csökkenés aránya a csak rosuvastatinterápián lévőknél 32%, a fi x kombinációs csoportnál 42% volt. A vizsgálatban alkalmazott lipidcsökkentőkkel összefüggő mellékhatás a 6 hónap alatt nem jelentkezett. Következtetés: Véleményünk szerint a következetesen alkalmazott, nagy intenzitású statin és ezetimib fi x kombinációs készítményekkel a betegek többségénél megvalósítható a hatásos érvédelem XXI. századi célkitűzése: a minél előbb elért, minél alacsonyabb LDL-C-szint biztosítása hosszú távon.
Machine learning from quantum chemistry to predict experimental solvent effects on reaction rates
Authors: Chung Yunsie , Green William H.
Published: January 2024

Fast and accurate prediction of solvent effects on reaction rates are crucial for kinetic modeling, chemical process design, and high-throughput solvent screening. Despite the recent advance in machine learning, a scarcity of reliable data has hindered the development of predictive models that are generalizable for diverse reactions and solvents. In this work, we generate a large set of data with the COSMO-RS method for over 28,000 neutral reactions and 295 solvents and train a machine learning model to predict the solvation free energy and solvation enthalpy of activation (ΔΔG‡solv, ΔΔH‡solv) for a solution phase reaction. On unseen reactions, the model achieves mean absolute errors of 0.71 and 1.03 kcal/mol for ΔΔG‡solv and ΔΔH‡solv, respectively, relative to the COSMO-RS calculations. The model also provides reliable predictions of relative rate constants within a factor of 4 when tested on experimental data. The presented model can provide nearly instantaneous predictions of kinetic solvent effects or relative rate constants for a broad range of neutral closed-shell or free radical reactions and solvents only based on atom-mapped reaction SMILES and solvent SMILES strings.
N2 dissociation on AuCoFeMoRu high-entropy alloys: Circumventing scaling relations and step dependencies
Authors: Christensen Oliver , Hutu Ana-Iulia , Høgh Kristoffersen Henrik , Rossmeisl Jan
Published: January 2024

Finding a better catalyst for the reduction of nitrogen to ammonia would be of considerable use to the chemical industry, allowing for cheaper and possibly decentralized ammonia production. One approach to find a better catalyst is to explore the element component space continuously via the use of high-entropy alloys, uncovering as of yet untested multi-element catalysts and reaction sites to optimize reaction activity. Utilizing DFT calculations and microkinetic modeling, we use the AuCoFeMoRu high-entropy alloy as a discovery platform for \ch{N2} reduction catalysts. Testing both terrace and step sites, we find that high-entropy alloy terraces can reach as high activities as steps for the \ch{N2} reduction reaction, due to their heterogeneous surface structure. We also find that high-entropy alloys are able to circumvent the scaling relations to an extent, due to the decoupling of the transition state and final state structure of the reaction. We discover several promising high-entropy alloy reaction sites, with a roughly twofold improvement in activity over the best monometallic surface. However, significantly larger gains in activity seem to still be fundamentally limited by the scaling relations.
Ion Mobility Mass Spectrometry for Synthetic Molecules: Expanding the Analytical Toolbox
Authors: Geue Niklas , Winpenny Richard E.P. , Barran Perdita
Published: January 2024

Understanding the composition, structure and stability of synthetic molecules is crucial for their design, yet currently the analytical tools commonly used do not readily provide this information, particularly for larger complex analytes above M = 500 Da. In this perspective, we show how ion mobility mass spectrometry (IM-MS), in combination with tandem mass spectrometry, computational methods and other complementary techniques, can be used to structurally characterise new synthetic molecules, make and predict new complexes, monitor disassembly processes and determine stability. Using IM-MS, we present an experimental and computational framework for the analysis and design of complex molecular architectures such as (metallo)supramolecular cages, interlocked molecules, rotaxanes, dendrimers, polymers and host-guest complexes.
Porous soft materials with liquid-glass-crystal interconvertibility based on metal-organic polyhedra
Authors: Han Po-Chun , Chuang Chia-Hui , Lin Shang-Wei , Wang Zaoming , Kuzumoto Mako , Xiang Xiangmei , Tokuda Shun , Tateishi Tomoki , Legrand Alexandre , Tsang Min Ying , Yang Hsiao-Ching , Wu Kevin C.-W. , Urayama Kenji , Kang Dun-Yen , Furukawa Shuhei
Published: January 2024

The capability of materials to interconvert between different phases provides more possibilities for controlling materials’ properties without additional chemical modification. The study of state-changing microporous materials just emerged and mainly involves the liquefication or amorphization of solid adsorbents into liquid or glass phases by adding non-porous components or sacrificing their porosity. The material featuring reversible phases with maintained porosity is, however, yet to be achieved. Here, we synthesize metal-organic polyhedra (MOPs) that interconvert between the liquid-glass-crystal phases. The modular synthetic approach is applied to integrate the core MOP cavity that provides permanent microporosity with tethered polymers that dictate the phase transition. We showcase the processibility of this material by fabricating a gas separation membrane featuring tunable permeability and selectivity by switching the state. The liquid MOP membrane particularly shows a unique selectivity of CO2 over H2 with enhanced permeability, compared to most conventional porous membranes.
A Computational Effort to Untangling Anti-SARS-CoV-2 Effects of Oleanolic Acid Analogues
Authors: Rajaei Baran
Published: January 2024

Considering urgent need for novel drugs to target severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), we reported at least four Kurdish ethno-medical, antipyretic recipes which can be translated into functional antiviral formulations. This computational work highlights the implications of oleanolic acid and its analogues as a cluster of binder candidates of SARS-CoV-2 main protease (Mpro). Through molecular docking and simulation, we found oleanolic acid (-12.6 Kcal/mol) and its two analogues (OA11; ligand I [-14.2 Kcal/mol]) and (OA31; ligand II [-14.0 Kcal/mol]) bound with Mpro (PDB: 6Y84) more reliably than saquinavir (-8.1 Kcal/mol), as a canonical drug. Salaspermic acid, (3b)-3-{[(2E)-3-phenylprop-2-enoyl]oxy}olean-12-en-28-oic acid, OA37 and OA40 interacted with catalytic dyad and major amino acid residues of Mpro active sites; these toxic compounds may be future anti-protease drug candidates. This study proposes this set of anti-protease pentacyclic triterpenoids should be assayed against SARS-CoV-2 at in vitro level or in clinical settings.
DOWNLOAD PDF DOWNLOAD XML EMPLOYEES’ JOB SATISFACTION USING HERZBERG’S TWO-FACTOR THEORY: EVIDENCE FROM THE FAST-FOOD RESTAURANTS IN PAGSANJAN, LAGUNA, PHILIPPINES
Authors: M. Macalinao John Matthew
Published: January 2024

Foods that can be quickly prepared are offered and served at quick-service restaurants. When time is limited and people are looking for meal options, these establishments offer the best solution. As a result, these establishments hire enough staff to guarantee smooth and effective operations. A recent survey by market research firm Clint revealed that close to 46% of Filipinos ate at fast restaurants one to three times a week on average. The fact that fast-food chains employed the greatest number of people in the fast-food industry suggested that this sector is the largest employer overall. This study sought to clarify the key elements of the method and identify and comprehend the variables that might affect the level of employees’ satisfaction. The study also looked into the relationship between job happiness and productivity. The conceptual framework for the study’s development and problem-solving procedure was Herzberg’s Two-Factor Theory. This theory was composed of two factors which argued that job satisfaction and dissatisfaction existed on two different continua, each with its factors. To gather the outcome of the administered research instrument, 147 respondents were requested to complete the checklist questionnaire. Participants were measured using a performance evaluation form to determine the relationship between fast-food employees’ job satisfaction and their performance. To ascertain the connection between job satisfaction and performance, discrepancies were categorized by demographic profile and then analyzed. The association between job satisfaction and demographic profile was shown to be correlated in a variety of ways, some of which were statistically different from others. Using a chi-square test, the relationship between job satisfaction and performance was investigated. The results showed a substantial correlation between the two variables. These results revealed whether or not the formulated hypothesis should be accepted.
FINANCIAL MANAGEMENT PRACTICES OF PUBLIC MARKET VENDORS OF LUCENA CITY PHILIPPINES: BASIS FOR BUSINESS SUSTAINABILITY
Authors: A. Asia Ma. Marieta
Published: January 2024

Public Market vendors are micro-entrepreneurs playing important roles in the economic condition of any locality. They created jobs for themselves and for others. The main objective of the study is to determine the financial management practices of public market vendors as a basis for business sustainability. Financial management practices have something to do with the set of common methods or standard operating procedures developed for carrying out business financial activities related to borrowing, budgeting, and savings. The researcher used descriptive and correlational research designs using a self-constructed questionnaire. Data were analyzed using various statistical tools such as Frequency and Percentage distribution, Weighted average Mean and Pearson R. The respondents of the study were one hundred (100) public market vendors of Lucena City, Philippines. The results showed that there is a significant relationship between financial management practices on budgeting on the business’ sustainability, while there is no significant relationship between financial management practices on savings and borrowing on business sustainability. Based on these findings, it is recommended that financial literacy on budgeting be given to the public market vendors as a form of government assistance to help the public market vendor sustain their business operation so as to improve the economic life of the people.
BRAND PREFERENCE OF LAPTOP AMONG BBA STUDENTS OF SUNDARHARAINCHA
Authors: Prasad Luitel Devendra
Published: January 2024

The research design used for this study is descriptive and it used a convenience sampling method that comes under the nonprobability sampling method and percentage, diagram, and pie-chart have been used to process and analyze data. Dell stood out as the most preferred brand and brand reliability or brand name came out to be the most influencing factor while purchasing a laptop it is followed by hardware, and other factors like an advertisement, support service, etc.,price, power backup, warranty offered, etc.
IMPACT OF INNOVATION INVESTMENT ON THE VALUE OF DIGITAL CREATIVE ENTERPRISES: THE MODERATING ROLE OF EXECUTIVE COGNITIVE ABILITY
Authors: Deng Zhenghua , Hu Xiao
Published: January 2024

Innovation investment is a crucial means for enterprises to maintain their competitive advantage and achieve transformation and upgrading. This paper examined the impact of innovation investment on the value of Chinese digital creative enterprises based on a sample of listed enterprises in this industry from 2015 to 2020, while considering the moderating role of executive cognitive ability. The findings reveal that innovation investment in Chinese digital creative enterprises has been increasing steadily in recent years and is positively associated with enterprise value. However, an inverted U-shaped relationship exists between innovation investment and enterprise value, as maintaining a moderate level of innovation investment is essential for the healthy development of digital creative enterprises. Moreover, executive cognitive ability can enhance the driving effect of innovation investment on enterprise value. After considering the lag effect of innovation investment, its impact on enterprise value becomes even more apparent.
IMPACT OF QUALITY OF CUSTOMER SERVICES ON CONSUMERS’ SATISFACTION IN AN ELECTRICITY COMPANY IN CALAMBA, LAGUNA
Authors: G. Anino Hannah Grace
Published: January 2024

The quality of individual customer service experiences can have a profound impact on consumer behavior and satisfaction. Customers’ satisfaction is the basis for enhancement in service quality. This study aimed to identify the impact of the quality of customer services in a determined context of an electric company in Calamba, Laguna. The findings provided relevant information affecting customers’ satisfaction and contributed insight on exploring customers’ satisfaction of an electrical power distribution provider. A total of 150 customers participated in the survey for this study. Convenient sampling was used to identify the respondents. Statistical tools to analyze the data include Likert scores per SERVQUAL, mean and variance. The results show that Empathy, Assurance, and Responsiveness are expressly related to the quality of customer services, which can lead to customers’ satisfaction. In addition, customers’ satisfaction was found to be significantly affected by service cost. The findings of this study suggested that more empathy should be shown by management for its customers and should consider increasing the number of customer service assistants to speed up the response time.
Electronic Nose Based on Piezoelectric Quartz Crystal for Mango Fruit Quality Assessment
Authors: Dulay Samuel B. , Albano Dharmatov Rahula B. , Sevilla III Fortunato B.
Published: January 2024

An electronic nose based on piezoelectric quartz crystal was developed for monitoring the maturation of carabao mango. This device detects the volatile organic compounds present in the headspace of the mango fruit. The crystals were coated with different organic organic polymers that interact with the volatile organic compounds, and this interaction was monitored through a self-assembled instrumentation and recorded by a computer in terms of frequency change. The quartz sensors gave stable response to the mango fruit sample, exhibited good repeatibility (r.s.d. = 3.3 to 5.5%, n=3) and good reproducibility (r.s.d. = 1.9 to 6.1%, n=5). Different signals were observed at different stages of the maturation of carabao mango fruit. The application of principal component analysis (PCA) enabled the discrimination of the responses of the electronic nose to mango fruits at different stages of maturation.
Molecular Recognition Properties of Artemisinin - Imprinted Polymer Microspheres
Authors: Malapit Christian A. , Lao Kendricks S. , Holdsworth Clovia , So Regina C.
Published: January 2024

The ability of molecularly-imprinted polymers (MIPs) to recognize and remember the shape of an imprinted molecule has expanded the application of these materials for separation and sample enrichment. This paper describes the binding efficiency and characteristics of an MIP prepared for the selective extraction of artemisinin, a potent anti-malaria compound present in Artemisia annua. Artemisinin is currently used in combination therapy for the treatment of severe cases of malaria.The MIP microspheres were obtained via precipitation polymerization using 5:6:20 mmol artemisinin/methacrylic acid/ethylene glycol dimethacrylate in 5% toluene/acetonitrile (95% v/v) solvent. This material showed high selectivity for artemisinin by rebinding experiments. Scatchard analysis was also carried out to further understand the binding characteristics of this material towards aremisinin.