bluuebunny/crossref_metadata_2025 huggingface dataset:
Actuarial Analysis of Survival among Breast Cancer Patients in Lithuania
Authors: Skučaitė Aldona , Puvačiauskienė Alma , Puišys Rokas , Šiaulys Jonas
Published: April 2021

Breast cancer is the most common cause of mortality due to cancer for women both in Lithuania and worldwide. Chances of survival after diagnosis differ significantly depending on the stage of disease at the time of diagnosis. Extended term periods are required to estimate survival of, e.g., 15–20 years. Moreover, since mortality of the average population changes with time, estimates of survival of cancer patients derived after a long period of observation can become outdated and can be no longer used to estimate survival of patients who were diagnosed later. Therefore, it can be useful to construct analytic functions that describe survival probabilities. Shorter periods of observation can be enough for such construction. We used the data collected by the Lithuanian Cancer Registry for our analysis. We estimated the chances of survival for up to 5 years after patients were diagnosed with breast cancer in Lithuania. Then we found analytic survival functions which best fit the observed data. At the end of this paper, we provided some examples for applications and directions for further research. We used mainly the Kaplan–Meier method for our study.
Surgical Stabilisation of Traumatic Rib Fractures with Chronic, Residual Type A Aortic Dissection
Authors: Matic Kieran J. , Cheluvappa Rajkumar , Selvendran Selwyn
Published: April 2021

Surgical stabilisation of rib fractures (SSRF) reduces morbidity and mortality. However, its impact in complicated cases, particularly those with underlying thoracic pathologies, is of continued interest. Electronic records were retrospectively reviewed after obtaining informed consent from the patient. This case report details a patient with chronic, residual, Stanford Type A aortic dissection (AD) who had multiple left-sided rib fractures with a flail segment after being struck by a bicycle. The preoperative computed tomography (CT) of the patient’s chest showed that the sixth posterior rib fracture location was just ~13 mm from the false lumen of the aorta. As the patient had poor respiratory output and persistent pain, SSRF was not performed on the posterior sections. However, the anterior third to seventh rib fractures were plated. The patient recovered fully, with reduced pain and improved respiratory function. This is the first report describing the benefits of SSRF with AD or major thoracic pathologies. Further research into the benefits of SSRF in specific thoracic pathologies may lead to improved patient outcomes. This may require the creation of profiles of patient cohorts with relevant clinical history to determine if SSRF may benefit patients with specific thoracic pathologies.
Association of Edentulism with Various Chronic Diseases in Mexican Elders 60+ Years: Results of a Population-Based Survey
Authors: Casanova-Rosado Alejandro José , Casanova-Rosado Juan Fernando , Minaya-Sánchez Mirna , Robles-Minaya José Luís , Casanova-Sarmiento Juan Alejandro , Márquez-Corona María de Lourdes , Pontigo-Loyola América Patricia , Isla-Granillo Horacio , Mora-Acosta Mariana , Márquez-Rodríguez Sonia , Medina-Solís Carlo Eduardo , Maupomé Gerardo
Published: April 2021

Objective: To determine the association of edentulism with different chronic diseases and mental disorders in Mexicans aged 60 years and over. Material and Methods: A cross-sectional study was carried out using data from the World Health Survey for Mexico, in a probabilistic, multi-stage cluster sampling framework. Data for self-report of chronic diseases (diabetes, arthritis, angina pectoris and asthma), mental disorders (depression and schizophrenia) and edentulism were analyzed. Edentulism data were available for 20 of the 32 States of Mexico. Statistical analysis was performed in Stata 14.0 using the svy module for complex sampling (Complex nature under which individuals are sampled). Results: In total 4213 subjects were included, representing a population of 7,576,057 individuals. Mean age was 70.13 ± 7.82 years (range 60 to 98); 56.2% were women. Chronic diseases’ prevalence and mental disorders prevalence were as follows: diabetes 15.0% (N = 1,132,693); arthritis 13.2% (N = 1,001,667); depression 5.5% (N = 414,912); angina pectoris 4.5% (344,315); asthma 3.6% (N = 269,287); and schizophrenia 2.2% (N = 16,988). The prevalence of edentulism was 26.3%, which pertained to 1,993,463 people aged 60 years and over. Angina in women aged 60 to 69 years (p < 0.05) and depression in men aged 70 years and over (p < 0.0001) were associated with higher prevalence of edentulism. Conclusions: There was generally sparse association between edentulism on chronic diseases and mental disorders included in the study, except for women aged 60 to 69 years for angina, and in men aged 70 and over, for depression. Although our findings are misaligned with previous reports, longitudinal studies are required to test causal and temporal relationships between edentulism with chronic diseases and mental disorders.
CWDAT—An Open-Source Tool for the Visualization and Analysis of Community-Generated Water Quality Data
Authors: Gray Annie , Robertson Colin , Feick Rob
Published: April 2021

Citizen science initiatives span a wide range of topics, designs, and research needs. Despite this heterogeneity, there are several common barriers to the uptake and sustainability of citizen science projects and the information they generate. One key barrier often cited in the citizen science literature is data quality. Open-source tools for the analysis, visualization, and reporting of citizen science data hold promise for addressing the challenge of data quality, while providing other benefits such as technical capacity-building, increased user engagement, and reinforcing data sovereignty. We developed an operational citizen science tool called the Community Water Data Analysis Tool (CWDAT)—a R/Shiny-based web application designed for community-based water quality monitoring. Surveys and facilitated user-engagement were conducted among stakeholders during the development of CWDAT. Targeted recruitment was used to gather feedback on the initial CWDAT prototype’s interface, features, and potential to support capacity building in the context of community-based water quality monitoring. Fourteen of thirty-two invited individuals (response rate 44%) contributed feedback via a survey or through facilitated interaction with CWDAT, with eight individuals interacting directly with CWDAT. Overall, CWDAT was received favourably. Participants requested updates and modifications such as water quality thresholds and indices that reflected well-known barriers to citizen science initiatives related to data quality assurance and the generation of actionable information. Our findings support calls to engage end-users directly in citizen science tool design and highlight how design can contribute to users’ understanding of data quality. Enhanced citizen participation in water resource stewardship facilitated by tools such as CWDAT may provide greater community engagement and acceptance of water resource management and policy-making.
Assessment of Rainfall-Induced Landslide Distribution Based on Land Disturbance in Southern Taiwan
Authors: Tseng Chih-Ming , Chen Yie-Ruey , Chang Chwen-Ming , Chue Yung-Sheng , Hsieh Shun-Chieh
Published: April 2021

This study explores the impact of rainfall on the followed-up landslides after a severe typhoon and the relationship between various rainfall events and the occurrence, scale, and regional characteristics of the landslides, including second landslides. Moreover, the influence of land disturbance was evaluated. The genetic adaptive neural network was used in combination with the texture analysis of the geographic information system for satellite image classification and interpretation to analyze land-use change and retrieve disaster records and surface information after five rainfall events from Typhoon Morakot (2009) to Typhoon Nanmadol (2011). The results revealed that except for extreme Morakot rains, the greater the degree of slope disturbance after rain, the larger the exposed slope. Extreme rainfall similar to Morakot strikes may have a greater impact on the bare land area than on slope disturbance. Moreover, the relationship between the bare land area and the index of land disturbance condition (ILDC) is positive, and the ratio of the bare land area to the quantity of bare land after each rainfall increases with the ILDC. With higher effective accumulative rainfall on the slope in the study area or greater slope disturbance, the landslide area at the second landslide point tended to increase.
Sensitivity Investigation on the Pressure Coefficients Non-Dimensionalization
Authors: Rizzo Fabio
Published: April 2021

The scaling of large structures to investigate their aerodynamics in wind tunnels is a common and robust procedure to estimate important magnitudes, including pressure coefficients. Different aspects can affect the estimation of pressure coefficients; four examples are the non-dimensionalization, blockage, non-stationarity, and non-Gaussianity of the wind tunnel velocity. This paper shows the variability of pressure coefficients due to these four aspects for the case study of a closed box section of a suspended bridge. It was estimated that the pressure coefficients of similar pressure taps vary significantly due to different sets of wind velocity time history used to non-dimensionalize the wind tunnel pressures. In addition, the stationarity of the wind velocity process was not confirmed for all wind velocity sets and the non-Gaussianity of the wind velocity time history was confirmed.
Post-Mortem Interval Estimation Based on Insect Evidence: Current Challenges
Authors: Matuszewski Szymon
Published: April 2021

During death investigations insects are used mostly to estimate the post-mortem interval (PMI). These estimates are only as good as they are close to the true PMI. Therefore, the major challenge for forensic entomology is to reduce the estimation inaccuracy. Here, I review literature in this field to identify research areas that may contribute to the increase in the accuracy of PMI estimation. I conclude that research on the development and succession of carrion insects, thermogenesis in aggregations of their larvae and error rates of the PMI estimation protocols should be prioritized. Challenges of educational and promotional nature are discussed as well, particularly in relation to the collection of insect evidence.
Review of Current Real-World Experience with Teriparatide as Treatment of Osteoporosis in Different Patient Groups
Authors: Hauser Barbara , Alonso Nerea , Riches Philip L
Published: April 2021

Teriparatide has proven effective in reducing both vertebral and non-vertebral fractures in clinical trials of post-menopausal and glucocorticoid-induced osteoporosis. Widespread adoption of Teriparatide over the last two decades means that there is now substantial experience of its use in routine clinical practice, which is summarized in this paper. Extensive real-world experience of Teriparatide in post-menopausal osteoporosis confirms the fracture and bone density benefits seen in clinical trials, with similar outcomes identified also in male and glucocorticoid-induced osteoporosis. Conversely, very limited experience has been reported in pre-menopausal osteoporosis or in the use of Teriparatide in combination with other therapies. Surveillance studies have identified no safety signals relating to the possible association of Teriparatide with osteosarcoma. We also review the evidence for predicting response to Teriparatide in order to inform the debate on where best to use Teriparatide in an increasingly crowded therapeutic landscape.
Adult Gambling Problems and Histories of Mental Health and Substance Use: Findings from a Prospective Multi-Wave Australian Cohort Study
Authors: Merkouris Stephanie S. , Greenwood Christopher J. , Youssef George J. , Letcher Primrose , Vassallo Suzanne , Dowling Nicki A. , Olsson Craig A.
Published: April 2021

Little is known about the cumulative effect of adolescent and young adult mental health difficulties and substance use problems on gambling behaviour in adulthood. We use data from one of Australia’s longest running studies of social and emotional development to examine the extent to which: (1) mental health symptoms (depressive and anxiety symptoms) and substance use (weekly binge drinking, tobacco, and cannabis use) from adolescence (13–18 years) into young adulthood (19–28 years) predict gambling problems in adulthood (31–32 years); and (2) risk relationships differ by sex. Analyses were based on responses from 1365 adolescent and young adult participants, spanning seven waves of data collection (1998–2014). Persistent adolescent to young adult binge drinking, tobacco use and cannabis use predicted gambling at age 31–32 years (OR = 2.30–3.42). Binge drinking and tobacco use in young adulthood also predicted gambling at age 31–32 years (OR = 2.04–2.54). Prior mental health symptoms were not associated with gambling and no risk relationships differed by sex. Findings suggest that gambling problems in adulthood may be related to the earlier development of other addictive behaviours, and that interventions targeting substance use from adolescence to young adulthood may confer additional gains in preventing later gambling behaviours.
The Impact of Lockdown on Couples’ Sex Lives
Authors: Costantini Elisabetta , Trama Francesco , Villari Donata , Maruccia Serena , Li Marzi Vincenzo , Natale Franca , Balzarro Matteo , Mancini Vito , Balsamo Raffaele , Marson Francesco , Bevacqua Marianna , Pastore Antonio Luigi , Ammirati Enrico , Gubbiotti Marilena , Filocamo Maria Teresa , De Rienzo Gaetano , Finazzi Agrò Enrico , Spatafora Pietro , Bisegna Claudio , Gemma Luca , Giammò Alessandro , Zucchi Alessandro , Brancorsini Stefano , Ruggiero Gennaro , Illiano Ester
Published: April 2021

Background: the aim of this study was to perform an Italian telematics survey analysis on the changes in couples’ sex lives during the coronavirus disease 2019 (COVID-19) lockdown. Methods: a multicenter cross sectional study was conducted on people sexually active and in stable relationships for at least 6 months. To evaluate male and female sexual dysfunctions, we used the international index of erectile function (IIEF-15) and the female sexual function index (FSFI), respectively; marital quality and stability were evaluated by the marital adjustment test (items 10–15); to evaluate the severity of anxiety symptoms, we used the Hamilton Anxiety Rating Scale. The effects of the quarantine on couples’ relationships was assessed with questions created in-house. Results: we included 2149 participants. The sex lives improved for 49% of participants, particularly those in cohabitation; for 29% it deteriorated, while for 22% of participants it did not change. Women who responded that their sex lives deteriorated had no sexual dysfunction, but they had anxiety, tension, fear, and insomnia. Contrarily, men who reported deteriorating sex lives had erectile dysfunctions and orgasmic disorders. In both genders, being unemployed or smart working, or having sons were risk factors for worsening the couples’ sex lives. Conclusion: this study should encourage evaluation of the long-term effects of COVID-19 on the sex lives of couples.
Prioritization of Novel Agents for Patients with Rhabdomyosarcoma: A Report from the Children’s Oncology Group (COG) New Agents for Rhabdomyosarcoma Task Force
Authors: Pacenta Holly L. , Allen-Rhoades Wendy , Langenau David , Houghton Peter J. , Keller Charles , Heske Christine M. , Deel Michael D. , Linardic Corinne M. , Shern Jack F. , Stewart Elizabeth , Turpin Brian , Harrison Douglas J. , Khan Javed , Mascarenhas Leo , Skapek Stephen X. , Meyer William H. , Hawkins Douglas S. , Chen Eleanor Y. , Amatruda James F. , Hingorani Pooja , Laetsch Theodore W.
Published: April 2021

Rhabdomyosarcoma is the most common soft tissue sarcoma diagnosed in children and adolescents. Patients that are diagnosed with advanced or relapsed disease have exceptionally poor outcomes. The Children’s Oncology Group (COG) convened a rhabdomyosarcoma new agent task force in 2020 to systematically evaluate novel agents for inclusion in phase 2 or phase 3 clinical trials for patients diagnosed with rhabdomyosarcoma, following a similar effort for Ewing sarcoma. The task force was comprised of clinicians and basic scientists who collectively identified new agents for evaluation and prioritization in clinical trial testing. Here, we report the work of the task force including the framework upon which the decisions were rendered and review the top classes of agents that were discussed. Representative agents include poly-ADP-ribose polymerase (PARP) inhibitors in combination with cytotoxic agents, mitogen-activated protein kinase (MEK) inhibitors in combination with type 1 insulin-like growth factor receptor (IGFR1) inhibitors, histone deacetylase (HDAC) inhibitors, and novel cytotoxic agents.
Optimal Skeletal Muscle Mass Index Cut-Off Values for Presarcopenia Evaluated by Computed Tomography against Dual-Energy X-ray Absorptiometry in Patients with Chronic Liver Disease
Authors: Ohashi Kazuki , Ishikawa Toru , Hoshii Asami , Hokari Tamaki , Noguchi Hirohito , Suzuki Mitsuyuki , Hirosawa Hiroshi , Imai Michitaka , Mitobe Yuta , Yoshida Toshiaki
Published: April 2021

Although dual-energy X-ray absorptiometry (DXA) and body impedance analysis are commonly used to measure skeletal muscle mass (SMM), a computed tomography (CT) scan is preferred in clinical practice. We aimed to propose the cut-off values of skeletal muscle mass index (SMI) calculated using CT scans, using DXA as the reference method. We retrospectively assessed 589 patients with chronic liver disease. The SMI was assessed using appendicular SMM by DXA and total muscle area at the level of the third lumbar vertebra (L3) calculated by CT. The cut-off value was determined with reference to the Asian Working Group for Sarcopenia criteria. DXA identified 251 (42.6%) patients as having presarcopenia. In men, the cut-off value of SMI for presarcopenia was determined to be 45.471 cm2/m2, with an area under the curve (AUC) of 0.863 (95% confidence interval (CI): 0.823 to 0.903), and in women, this value was determined to be 35.170 cm2/m2, with an AUC of 0.846 (95% CI: 0.800 to 0.892). Cohen’s kappa coefficient was 0.575 (95% CI: 0.485–0.665) in men and 0.539 (95% CI: 0.438–0.639) in women.
Left Atrial Appendage Closure with a New Occluder Device: Efficacy, Safety and Mid-Term Performance
Authors: Llagostera-Martín Marc , Cubero-Gallego Hector , Mas-Stachurska Aleksandra , Salvatella Neus , Sánchez-Carpintero Andrea , Tizon-Marcos Helena , Garcia-Guimaraes Marcos , Calvo-Fernandez Alicia , Molina Luis , Vaquerizo Beatriz
Published: April 2021

The LAmbreTM device is a novel system designed for left atrial appendage closure (LAAC). First registries showed a high rate of device implantation success. However, few mid-term results are available. We present our 1- and 12-month follow-up results for this device. This prospective, single-center registry included consecutive patients with nonvalvular atrial fibrillation who underwent LAAC with the LAmbreTM device. Transesophageal echocardiography (TEE) was performed at 1-month follow-up. In total, 55 patients were included. The population was elderly (75 ± 9.4 years), with a high proportion of comorbidities. The mean CHA2DS2-VASc and HAS-BLED scores were 4.6 ± 1.6 and 3.9 ± 1.0, respectively. Previous history of a major bleeding event was present in 37 patients (67.3%). Procedural success was achieved in 54 patients (98.2%). Device success was achieved in 100% of patients in whom device implantation was attempted (54 patients). Major in-hospital device-related complications included mortality of one patient (1.8%) and pericardial tamponade in two patients (3.6%); the incidence of stroke was 0%. No thrombus or significant leaks (≥5 mm) were observed on 1-month TEE. At 12 months, adverse events were overall death (1.8%), transient ischemic attack/ischemic stroke (1.8%), and major bleeding events (Bleeding Academic Research Consortium (BARC) 3a and 3c; 11%). In this high-risk population, the LAmbreTM device seems to be a safe and effective option for LAAC with a remarkable mid-term performance.
Prevalence of COVID-19 Vaccine Side Effects among Healthcare Workers in the Czech Republic
Authors: Riad Abanoub , Pokorná Andrea , Attia Sameh , Klugarová Jitka , Koščík Michal , Klugar Miloslav
Published: April 2021

Background: COVID-19 vaccine side effects have a fundamental role in public confidence in the vaccine and its uptake process. Thus far, the evidence on vaccine safety has exclusively been obtained from the manufacturer-sponsored studies; therefore, this study was designed to provide independent evidence on Pfizer–BioNTech COVID-19 vaccine side effects. Methods: A cross-sectional survey-based study was carried out between January and February 2021 to collect data on the side effects following the COVID-19 vaccine among healthcare workers in the Czech Republic. The study used a validated questionnaire with twenty-eight multiple-choice items covering the participants’ demographic data, medical anamneses, COVID-19-related anamneses, general, oral, and skin-related side effects. Results: Injection site pain (89.8%), fatigue (62.2%), headache (45.6%), muscle pain (37.1%), and chills (33.9%) were the most commonly reported side effects. All the general side effects were more prevalent among the ≤43-year-old group, and their duration was mainly one day (45.1%) or three days (35.8%) following the vaccine. Antihistamines were the most common drugs associated with side effects, thus requiring further investigation. The people with two doses were generally associated with a higher frequency of side effects. Conclusions: The distribution of side effects among Czech healthcare workers was highly consistent with the manufacturer’s data, especially in terms of their association with the younger age group and the second dose. The overall prevalence of some local and systemic side effects was higher than the manufacturer’s report. Further independent studies on vaccine safety are strongly required to strengthen public confidence in the vaccine.
Celia’s Encephalopathy (BSCL2-Gene-Related): Current Understanding
Authors: Sánchez-Iglesias Sofía , Fernández-Pombo Antía , Cobelo-Gómez Silvia , Hermida-Ameijeiras Álvaro , Alarcón-Martínez Helena , Domingo-Jiménez Rosario , Ruíz Riquelme Alejandro Iván , Requena Jesús R. , Araújo-Vilar David
Published: April 2021

Seipin, encoded by the BSCL2 gene, is a protein that in humans is expressed mainly in the central nervous system. Uniquely, certain variants in BSCL2 can cause both generalized congenital lipodystrophy type 2, upper and/or lower motor neuron diseases, or progressive encephalopathy, with a poor prognosis during childhood. The latter, Celia’s encephalopathy, which may or may not be associated with generalized lipodystrophy, is caused by the c.985C >T variant. This cytosine to thymine transition creates a cryptic splicing zone that leads to intronization of exon 7, resulting in an aberrant form of seipin, Celia seipin. It has been proposed that the accumulation of this protein, both in the endoplasmic reticulum and in the nucleus of neurons, might be the pathogenetic mechanism of this neurodegenerative condition. In recent years, other variants in BSCL2 associated with generalized lipodystrophy and progressive epileptic encephalopathy have been reported. Interestingly, most of these variants could also lead to the loss of exon 7. In this review, we analyzed the molecular bases of Celia’s encephalopathy and its pathogenic mechanisms, the clinical features of the different variants, and a therapeutic approach in order to slow down the progression of this fatal neurological disorder.
ANCA-Associated Vasculitis: An Update
Authors: Almaani Salem , Fussner Lynn A. , Brodsky Sergey , Meara Alexa S. , Jayne David
Published: April 2021

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) represents a group of small vessel vasculitides characterized by granulomatous and neutrophilic tissue inflammation, often associated with the production of antibodies that target neutrophil antigens. The two major antigens targeted by ANCAs are leukocyte proteinase 3 (PR3) and myeloperoxidase (MPO). AAV can be classified into 3 categories based on patterns of clinical involvement: namely, granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eosinophilic GPA (EGPA). Clinically, AAV involves many organ systems including the lungs, kidneys, skin, and nervous system. The prognosis of AAV has improved dramatically due to advances in the understanding of its pathogenesis and treatment modalities. This review will highlight some of the recent updates in our understanding of the pathogenesis, clinical manifestations, and treatment options in patients with AAV focusing on kidney involvement.
Clinical Significance of Tumor Microenvironment in Acral Melanoma: A Large Single-Institution Study of Caucasians
Authors: Borkowska Aneta Maria , Szumera-Ciećkiewicz Anna , Chraszczewska Maria , Sokół Kamil , Goryń Tomasz , Rutkowski Piotr Łukasz
Published: April 2021

Background: The presence of tumor-infiltrating lymphocytes (TILs) in many studies is associated with a better prognosis in melanoma patients. Programmed death-ligand 1 (PD-L1) expression has a significant value in predicting several cancers, but its role in melanoma remains ambiguous. The study aims to report a comprehensive analysis of TILs characteristics and their impact on survival in primary acral melanoma (AM). Methods: Clinical and pathological features and survival outcomes were investigated in 70 patients with AM. Immunohistochemical quantitative analysis of TILs, including expression of CD4, CD8, FOXP3, PD-1, and PD-L1, on melanoma cells was performed. Results: Kaplan-Meier analysis showed significant differences in overall survival (OS) for CD4+ (p = 0.021), CD8+ (p = 0.037), FOXP3+ (p = 0.007), and TILs density (p = 0.043). In univariate analysis of immunohistochemical features, FOXP3, CD4, CD8, PD-1, and Melanoma Institute of Australia (MIA) grading TILs (grade, density, and distribution) were correlated with survival. The higher density of FOXP3-positive cells was an independent factor associated with better survival. Conclusions: High TILs content (classed as brisk Clark scale and marked/diffuse TILs MIA grade) regardless of its immunophenotype was associated with better survival outcomes in AM. PD-L1 expression on tumor cells did not influence OS and was independent of clinical and pathological characteristics. We demonstrated that TILs are significant biomarkers in sentinel lymph node status prediction.
Flexural Characteristics of Functionally Graded Fiber-Reinforced Cementitious Composite with Polyvinyl Alcohol Fiber
Authors: Kanakubo Toshiyuki , Koba Takumi , Yamada Kohei
Published: April 2021

The objective of this study is to investigate the flexural characteristics of functionally graded fiber-reinforced cementitious composite (FG-FRCC) concerning the fiber volume fraction (Vf) varying in layers and the layered effect in bending specimens. The FG-FRCC specimens, in which Vf increases from 0% in the compression zone to 2% in the tensile zone, are three-layered specimens using polyvinyl alcohol (PVA) FRCC that are fabricated and tested by a four-point bending test. The maximum load of the FG-FRCC specimens exhibits almost twice that of homogeneous specimens, even when the average of the fiber volume fraction in the whole specimen is 1%. The result of the section analysis, in which the stress–strain models based on the bridging law (tensile stress–crack width relationship owned by the fibers) consider the fiber orientation effect, shows a good adaptability with the experiment result.
The Effect of Hull Form Parameters on the Hydrodynamic Performance of a Bulk Carrier
Authors: Deng Rui , Wang Shigang , Hu Yuxiao , Wang Yuquan , Wu Tiecheng
Published: April 2021

In this study, the effect of joint optimization of the principal dimensions and hull form on the hydrodynamic performance of a bulk carrier was studied. In the first part of the joint optimization process, fast principal-dimension optimization of the origin parent ship considering the integrated performance of ship resistance, seakeeping, and maneuverability, as well as their relationships with the principal dimensions were analyzed in detail based on the ship resistance, seakeeping qualities, and maneuverability empirical methods of Holtrop and Mennen, Bales, and K and T indices, respectively. A new parent ship was chosen from 496 sets of hulls after comprehensive consideration. In the remaining part, a further hull form optimization was performed on the new parent ship according to the minimum wave-making resistance. The obtained results demonstrate that: (a) For the case in which the principal dimension of the original parent-type ship is different from that of the owner’s target ship, within the bounds of the relevant constraints from the owner, an excellent parent ship can be obtained by principal-dimension optimization; (b) the joint optimization method considering the principal dimension and hull form optimization can further explore the optimization space and provide a better hull.
A Rapid Screening Program for Histoplasmosis, Tuberculosis, and Cryptococcosis Reduces Mortality in HIV Patients from Guatemala
Authors: Medina Narda , Alastruey-Izquierdo Ana , Bonilla Oscar , Gamboa Osmar , Mercado Danicela , Pérez Juan C. , Salazar Luis Roberto , Arathoon Eduardo , Denning David W. , Rodriguez-Tudela Juan Luis
Published: April 2021

Opportunistic infections (OIs) and advanced HIV disease (AHD) contribute to HIV-related mortality. Here, we analyzed the situation of AHD and OIs in a cohort of newly diagnosed HIV patients from Guatemala. We included 2127 adult patients from 13 facilities across the country during 2017 to 2018. Patients were screened for tuberculosis (TB), nontuberculous mycobacteria (NTM), histoplasmosis, and cryptococcal disease, independently of their CD4 cell count. Of the 2127 enrolled patients, 1682 (79.1%) had a CD4 cell count available; of which 52% presented with AHD. Of the Mayan population, 65% had AHD. The overall OI incidence was 21%. Histoplasmosis was the most frequent OI (7.9%), followed by TB (7.1%); 94.4% of these infections occurred in patients with a CD4 < 350 cells/mm3. Mortality at 180 days was significantly higher in those with OIs than without OIs (29.7% vs. 5.9%, p < 0.0001). In one year, this program decreased the OI mortality by 7% and increased the OI treatment by 5.1%. Early OI diagnosis and appropriate therapy reduced OI mortality among newly diagnosed HIV patients in Guatemala. Screening for OIs should be considered in all newly diagnosed HIV patients who have a CD4 cell count < 350 cells/mm3 or those without a CD4 cell count available. To improve results, interventions such as early HIV detection and access to flucytosine and liposomal amphotericin B are required.
Identifying Conserved Generic Aspergillus spp. Co-Expressed Gene Modules Associated with Germination Using Cross-Platform and Cross-Species Transcriptomics
Authors: Baltussen Tim J. H. , Coolen Jordy P. M. , Verweij Paul E. , Dijksterhuis Jan , Melchers Willem J. G.
Published: April 2021

Aspergillus spp. is an opportunistic human pathogen that may cause a spectrum of pulmonary diseases. In order to establish infection, inhaled conidia must germinate, whereby they break dormancy, start to swell, and initiate a highly polarized growth process. To identify critical biological processes during germination, we performed a cross-platform, cross-species comparative analysis of germinating A. fumigatus and A. niger conidia using transcriptional data from published RNA-Seq and Affymetrix studies. A consensus co-expression network analysis identified four gene modules associated with stages of germination. These modules showed numerous shared biological processes between A. niger and A. fumigatus during conidial germination. Specifically, the turquoise module was enriched with secondary metabolism, the black module was highly enriched with protein synthesis, the darkgreen module was enriched with protein fate, and the blue module was highly enriched with polarized growth. More specifically, enriched functional categories identified in the blue module were vesicle formation, vesicular transport, tubulin dependent transport, actin-dependent transport, exocytosis, and endocytosis. Genes important for these biological processes showed similar expression patterns in A. fumigatus and A. niger, therefore, they could be potential antifungal targets. Through cross-platform, cross-species comparative analysis, we were able to identify biologically meaningful modules shared by A. fumigatus and A. niger, which underscores the potential of this approach.
Risk Assessment for Heroin Use and Craving Score Using Polygenic Risk Score
Authors: Huang Chieh-Liang , Chen Ping-Ho , Lane Hsien-Yuan , Ho Ing-Kang , Chung Chia-Min
Published: April 2021

Addiction is characterized by drug-craving, compulsive drug-taking, and relapse, and results from the interaction between multiple genetic and environmental factors. Reward pathways play an important role in mediating drug-seeking and drug-taking behaviors, and relapse. The objective of this study was to identify heroin addicts who carry specific genetic variants in their dopaminergic reward systems. A total of 326 heroin-dependent patients undergoing methadone maintenance therapy (MMT) were recruited from the Addiction Center of the China Medical University Hospital. A heroin-use and craving questionnaire was used to evaluate the urge for heroin, the daily or weekly frequency of heroin usage, daily life disturbance, anxiety, and the ability to overcome heroin use. A general linear regression model was used to assess the associations of genetic polymorphisms in one’s dopaminergic reward system with heroin-use and craving scores. Results: The most significant results were obtained for rs2240158 in GRIN3B (p = 0.021), rs3983721 in GRIN3A (p = 0.00326), rs2129575 in TPH2 (p = 0.033), rs6583954 in CYP2C19 (p = 0.033), and rs174699 in COMT (p = 0.036). These were all associated with heroin-using and craving scores with and without adjustments for age, sex, and body mass index. We combined five variants, and the ensuing dose-response effect indicated that heroin-craving scores increased with the numbers of risk alleles (p for trend = 0.0008). These findings will likely help us to understand the genetic mechanism of craving, which will help in predicting the risk of relapse in clinical practice and the potential for therapies to target craving in heroin addiction.
Multiomic Analysis of Cereblon Expression and Its Prognostic Value in Kidney Renal Clear Cell Carcinoma, Lung Adenocarcinoma, and Skin Cutaneous Melanoma
Authors: Shin Hyo Jae , Lee Kyung Jin , Gil Minchan
Published: April 2021

Cereblon (CRBN) is a component of the E3 ubiquitin ligase complex that plays crucial roles in various cellular processes. However, no systematic studies on the expression and functions of CRBN in solid tumors have been conducted to date. Here, we analyzed CRBN expression and its clinical value using several bioinformatic databases. CRBN mRNA expression was downregulated in various cancer types compared to normal cells. Survival analysis demonstrated that overall survival was significantly positively correlated with CRBN expression in some cancer types including lung adenocarcinoma (LUAD), kidney renal clear cell carcinoma (KIRC), and skin cutaneous melanoma (SKCM). CRBN expression was downregulated regardless of clinicopathological characteristics in LUAD and KIRC. Analysis of genes that are commonly correlated with CRBN expression among KIRC, LUAD, and SKCM samples elucidated the potential CRBN-associated mechanisms of cancer progression. Overall, this study revealed the prognostic value of CRBN and its potential associated mechanisms, which may facilitate the development of anti-cancer therapeutic agents.
The Impact of Local Green Spaces of Historically and Culturally Valuable Residential Areas on Place Attachment
Authors: Hosseini Fatemeh , Sajadzadeh Hassan , Aram Farshid , Mosavi Amir
Published: April 2021

Environmental qualities significantly affect the behaviors and place attachment of users, especially in residential areas. In addition to creating environmental comfort, local green spaces can increase users’ place attachment, improve their mood, enhance friendly company and facilitate social interactions. The study sought to investigate the impact of local green spaces in the historically and culturally valuable residential fabric of Hamadan City in Iran on increasing residents’ social attachment. Derived from the literature on the subject, the conceptual model of the study shows the impact of such factors as social, functional, emotional and spatial bonds on place attachment in the residential context. A total number of 410 residents in the old neighborhoods of Hamadan City were selected by random sampling with a balanced proportion of gender and residence duration in the selected area. The designed questionnaire was distributed among the sample population and the collected data were analyzed using the structural equation modeling method. Then, the t-test and bootstrapping in Smart PLS software were used for testing the research hypotheses and evaluating the significance of the relationships between the research variables in the structural model. The results indicated that among the four types of bonds examined in relation to place attachment, emotional bonds, functional bonds, social bonds and spatial bonds, respectively, had a direct and significant impact on place attachment from the viewpoint of residents. The stronger the sociocultural bonds in historically and culturally valuable residential areas, the more prominent the role of local green spaces in place attachment based on residence duration becomes.
The Role of Land Use Transition on Industrial Pollution Reduction in the Context of Innovation-Driven: The Case of 30 Provinces in China
Authors: Meng Yanjun , Wang Kun , Lin Yuanyuan
Published: April 2021

With the world calling for environmental protection, China has to follow an innovation-driven development path in order to achieve its own high-quality and sustainable development. During this period, the problem of inefficient land use resulting from rapid progress in urbanisation is difficult to ignore. This study uses data from 30 provinces in mainland China to analyse the environmental protection effects of land use transition towards innovation-driven development, using spatial econometric models and entropy method. The results show that the innovation-oriented land use transition in four dimensions, human capital, material capital, urban function and government, is conducive to reducing industrial pollution emissions in the region, but this effect does not have a spillover effect. The results of this study provide some insights into the “triple-win” (environmental protection, innovation and land-use optimisation) approach to economic development in China.
Responses of Soil Infiltration to Water Retention Characteristics, Initial Conditions, and Boundary Conditions
Authors: An Lesheng , Liao Kaihua , Liu Chun
Published: April 2021

(1) Background: Simulation of soil water infiltration process and analysis of its influencing factors are important for water resources management. (2) Methods: In this study, the relative contributions of the soil water retention characteristics (SWRC) estimation, initial water content, and constant pressure head at upper boundary to the cumulative infiltration under various soil conditions were quantified based on the 1-D Richards’ equation and 900 scenarios. Scenario simulations were performed for two SWRC estimation methods (Jensen method and Rosetta); three different initial water contents (0.15, 0.20, and 0.25 cm3/cm3); five different constant pressure heads (0.5, 1, 2, 4, and 8 cm); and thirty soil samples with varying texture and bulk density. (3) Results: Rosetta representing the drying branch of the SWRC yielded higher simulated cumulative infiltration compared with the Jensen method representing the wetting branch of the SWRC. However, the Jensen method–predicted cumulative infiltration fluxes matched well with the measured values with a low RMSE of 0.80 cm. (4) Conclusions: The relative contribution of the SWRC estimation method to cumulative infiltration (19.1–72.2%) was compared to that of constant pressure head (14.0–65.5%), and generally greater than that of initial water content (2.2–29.9%). Findings of this study have practical significance for investigating the transport of water, nutrients, and contaminants in the unsaturated zone.
Association between Vascular Inflammation and Inflammation in Adipose Tissue, Spleen, and Bone Marrow in Patients with Psoriasis
Authors: Kaiser Hannah , Kvist-Hansen Amanda , Krakauer Martin , Gørtz Peter Michael , Henningsen Kristoffer Mads Aaris , Wang Xing , Becker Christine , Zachariae Claus , Skov Lone , Hansen Peter Riis
Published: April 2021

Psoriasis is associated with atherosclerotic cardiovascular disease (CVD) with significant overlap of inflammatory pathways. A link between vascular inflammation and inflammation in multiple adipose tissue types, spleen, and bone marrow may exist. Therefore, we investigated these associations using 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) in patients with psoriasis (n = 83) where half had established CVD. Carotid ultrasound imaging was also performed. Inflammation was measured by FDG uptake in the aorta, visceral- (VAT), subcutaneous- (SAT), and pericardial (PAT) adipose tissues, and spleen and bone marrow, respectively. Vascular inflammation was associated with FDG uptakes in all adipose tissues, including VAT (β = 0.26; p < 0.001), SAT (β = 0.28; p < 0.001), PAT (β = 0.24; p < 0.001), spleen (β = 1.35; p = 0.001), and bone marrow (β = 1.14; p < 0.001). Adjustments for age, sex, body mass index, and high sensitivity C-reactive protein did not change the results. These associations were generally preserved in the patients without prior CVD. No associations were observed between vascular inflammation and carotid intima-media thickness or presence of carotid plaques, respectively. The results suggest an inflammatory link between vascular and adipose tissues, spleen, and bone marrow in patients with psoriasis.
Precipitation Behavior of Mg-7Gd-3Y-2Zn-0.5Zr Alloy during Isothermal Aging
Authors: Yuan Jiawei , Li Ting , Zhang Kui , Li Xinggang , Li Yongjun , Ma Minglong , Shi Guoliang , Du Zhiwei , Liu Wei , Peng Yonggang
Published: April 2021

Precipitate phases in an Mg–7Gd–3Y–2Zn–0.5Zr alloy aged isothermally at 240 °C were examined using high-resolution transmission electron microscopy (TEM) and high-angle annular dark-field scanning TEM. The two types of precipitation sequence that involve Mg–Gd and long period stacking ordered (LPSO) type were found. The LPSO type sequence consisted of the precipitation of γ′′, γ′, 14H-LPSO/18R-LPSO. The Mg–Gd type precipitation sequence involved the formation of β′(b.c.o.) and β1(f.c.c.). The sequence, morphology, distribution, and crystal structure of these precipitates formed during isothermal aging were investigated. The results indicated that the priority precipitation of Mg–Gd and LPSO type sequences during aging can be affected by Nd, which has a higher diffusion coefficient than Gd and Y. The dislocation structures and strengthening mechanism were also discussed.
Research on Motion Planning Based on Flocking Control and Reinforcement Learning for Multi-Robot Systems
Authors: Wang Minghui , Zeng Bi , Wang Qiujie
Published: April 2021

Robots have poor adaptive ability in terms of formation control and obstacle avoidance control in unknown complex environments. To address this problem, in this paper, we propose a new motion planning method based on flocking control and reinforcement learning. It uses flocking control to implement a multi-robot orderly motion. To avoid the trap of potential fields faced during flocking control, the flocking control is optimized, and the strategy of wall-following behavior control is designed. In this paper, reinforcement learning is adopted to implement the robotic behavioral decision and to enhance the analytical and predictive abilities of the robot during motion planning in an unknown environment. A visual simulation platform is developed in this paper, on which researchers can test algorithms for multi-robot motion control, such as obstacle avoidance control, formation control, path planning and reinforcement learning strategy. As shown by the simulation experiments, the motion planning method presented in this paper can enhance the abilities of multi-robot systems to self-learn and self-adapt under a fully unknown environment with complex obstacles.
Study of Reversible Platelet Aggregation Model by Nonlinear Dynamics
Authors: Vasilev Grigorii A. , Filkova Aleksandra A. , Sveshnikova Anastasia N.
Published: April 2021

Blood cell platelets form aggregates upon vessel wall injury. Under certain conditions, a disintegration of the platelet aggregates, called “reversible aggregation”, is observed in vitro. Previously, we have proposed an extremely simple (two equations, five parameters) ordinary differential equation-based mathematical model of the reversible platelet aggregation. That model was based on mass-action law, and the parameters represented probabilities of platelet aggregate formations. Here, we aimed to perform a nonlinear dynamics analysis of this mathematical model to derive the biomedical meaning of the model’s parameters. The model’s parameters were estimated automatically from experimental data in COPASI software. Further analysis was performed in Python 2.7. Contrary to our expectations, for a broad range of parameter values, the model had only one steady state of the stable type node, thus eliminating the initial assumption that the reversibility of the aggregation curve could be explained by the system’s being near a stable focus. Therefore, we conclude that during platelet aggregation, the system is outside of the influence area of the steady state. Further analysis of the model’s parameters demonstrated that the rate constants for the reaction of aggregate formation from existing aggregates determine the reversibility of the aggregation curve. The other parameters of the model influenced either the initial aggregation rate or the quasi-steady state aggregation values.
Fuzzy Inner Product Space: Literature Review and a New Approach
Authors: Popa Lorena , Sida Lavinia
Published: April 2021

The aim of this paper is to provide a suitable definition for the concept of fuzzy inner product space. In order to achieve this, we firstly focused on various approaches from the already-existent literature. Due to the emergence of various studies on fuzzy inner product spaces, it is necessary to make a comprehensive overview of the published papers on the aforementioned subject in order to facilitate subsequent research. Then we considered another approach to the notion of fuzzy inner product starting from P. Majundar and S.K. Samanta’s definition. In fact, we changed their definition and we proved some new properties of the fuzzy inner product function. We also proved that this fuzzy inner product generates a fuzzy norm of the type Nădăban-Dzitac. Finally, some challenges are given.