bluuebunny/crossref_metadata_2025 huggingface dataset:
SMAT
Authors: Li Jiajia , Tan Guangming , Chen Mingyu , Sun Ninghui
Published: July 2013

Sparse Matrix Vector multiplication (SpMV) is an important kernel in both traditional high performance computing and emerging data-intensive applications. By far, SpMV libraries are optimized by either application-specific or architecture-specific approaches, making the libraries become too complicated to be used extensively in real applications. In this work we develop a Sparse Matrix-vector multiplication Auto-Tuning system (SMAT) to bridge the gap between specific optimizations and general-purpose usage. SMAT provides users with a unified programming interface in compressed sparse row (CSR) format and automatically determines the optimal format and implementation for any input sparse matrix at runtime. For this purpose, SMAT leverages a learning model, which is generated in an off-line stage by a machine learning method with a training set of more than 2000 matrices from the UF sparse matrix collection, to quickly predict the best combination of the matrix feature parameters. Our experiments show that SMAT achieves impressive performance of up to 51GFLOPS in single-precision and 37GFLOPS in double-precision on mainstream x86 multi-core processors, which are both more than 3 times faster than the Intel MKL library. We also demonstrate its adaptability in an algebraic multigrid solver from Hypre library with above 20% performance improvement reported.
Translation validation for a verified OS kernel
Authors: Sewell Thomas Arthur Leck , Myreen Magnus O. , Klein Gerwin
Published: July 2013

We extend the existing formal verification of the seL4 operating system microkernel from 9500 lines of C source code to the binary level. We handle all functions that were part of the previous verification. Like the original verification, we currently omit the assembly routines and volatile accesses used to control system hardware.

More generally, we present an approach for proving refinement between the formal semantics of a program on the C source level and its formal semantics on the binary level, thus checking the validity of compilation, including some optimisations, and linking, and extending static properties proved of the source code to the executable. We make use of recent improvements in SMT solvers to almost fully automate this process.

We handle binaries generated by unmodified gcc 4.5.1 at optimisation level 1, and can handle most of seL4 even at optimisation level 2.
P
Authors: Desai Ankush , Gupta Vivek , Jackson Ethan , Qadeer Shaz , Rajamani Sriram , Zufferey Damien
Published: July 2013

We describe the design and implementation of P, a domain-specific language to write asynchronous event driven code. P allows the programmer to specify the system as a collection of interacting state machines, which communicate with each other using events. P unifies modeling and programming into one activity for the programmer. Not only can a P program be compiled into executable code, but it can also be tested using model checking techniques. P allows the programmer to specify the environment, used to "close" the system during testing, as nondeterministic ghost machines. Ghost machines are erased during compilation to executable code; a type system ensures that the erasure is semantics preserving.

The P language is designed so that a P program can be checked for responsiveness---the ability to handle every event in a timely manner. By default, a machine needs to handle every event that arrives in every state. But handling every event in every state is impractical. The language provides a notion of deferred events where the programmer can annotate when she wants to delay processing an event. The default safety checker looks for presence of unhandled events. The language also provides default liveness checks that an event cannot be potentially deferred forever.

P was used to implement and verify the core of the USB device driver stack that ships with Microsoft Windows 8. The resulting driver is more reliable and performs better than its prior incarnation (which did not use P); we have more confidence in the robustness of its design due to the language abstractions and verification provided by P.
Finding optimum abstractions in parametric dataflow analysis
Authors: Zhang Xin , Naik Mayur , Yang Hongseok
Published: July 2013

We propose a technique to efficiently search a large family of abstractions in order to prove a query using a parametric dataflow analysis. Our technique either finds the cheapest such abstraction or shows that none exists. It is based on counterexample-guided abstraction refinement but applies a novel meta-analysis on abstract counterexample traces to efficiently find abstractions that are incapable of proving the query. We formalize the technique in a generic framework and apply it to two analyses: a type-state analysis and a thread-escape analysis. We demonstrate the effectiveness of the technique on a suite of Java benchmark programs.
Harmonizing classes, functions, tuples, and type parameters in virgil iii
Authors: Titzer Ben L.
Published: July 2013

Languages are becoming increasingly multi-paradigm. Subtype polymorphism in statically-typed object-oriented languages is being supplemented with parametric polymorphism in the form of generics. Features like first-class functions and lambdas are appearing everywhere. Yet existing languages like Java, C#, C++, D, and Scala seem to accrete ever more complexity when they reach beyond their original paradigm into another; inevitably older features have some rough edges that lead to nonuniformity and pitfalls. Given a fresh start, a new language designer is faced with a daunting array of potential features. Where to start? What is important to get right first, and what can be added later? What features must work together, and what features are orthogonal? We report on our experience with Virgil III, a practical language with a careful balance of classes, functions, tuples and type parameters. Virgil intentionally lacks many advanced features, yet we find its core feature set enables new species of design patterns that bridge multiple paradigms and emulate features not directly supported such as interfaces, abstract data types, ad hoc polymorphism, and variant types. Surprisingly, we find variance for function types and tuple types often replaces the need for other kinds of type variance when libraries are designed in a more functional style.
Limitations of partial compaction
Authors: Cohen Nachshon , Petrank Erez
Published: July 2013

Compaction of a managed heap is considered a costly operation, and is avoided as much as possible in commercial runtimes. Instead, partial compaction is often used to defragment parts of the heap and avoid space blow up. Previous study of compaction limitation provided some initial asymptotic bounds but no implications for practical systems. In this work, we extend the theory to obtain better bounds and make them strong enough to become meaningful for modern systems.
Modulation of Soluble Guanylate Cyclase for the Treatment of Erectile Dysfunction
Authors: Lasker George F. , Pankey Edward A. , Kadowitz Philip J.
Published: July 2013

Nitric oxide (NO) is the principal mediator of penile erection, and PDE-5 inhibitors are the first-line agents used to treat erectile dysfunction (ED). When NO formation or bioavailability is decreased by oxidative stress and PDE-5 inhibitors are no longer effective, a new class of agents called soluble guanylate cyclase (sGC) stimulators like BAY 41-8543 will induce erection. sGC stimulators bind to the normally reduced, NO-sensitive form of sGC to increase cGMP formation and promote erection. The sGC stimulators produce normal erectile responses when NO formation is inhibited and the nerves innervating the corpora cavernosa are damaged. However, with severe oxidative stress, the heme iron on sGC can be oxidized, rendering the enzyme unresponsive to NO or sGC stimulators. In this pathophysiological situation, another newly developed class of agents called sGC activators can increase the catalytic activity of the oxidized enzyme, increase cGMP formation, and promote erection. The use of newer agents that stimulate or activate sGC to promote erection and treat ED is discussed in this brief review article.
Hypertension: What's Sex Got to do With It?
Authors: Zimmerman Margaret A. , Sullivan Jennifer C.
Published: July 2013

Hypertension is a complex and multifaceted disease, and there are well established sex differences in many aspects of blood pressure (BP) control. The intent of this review is to highlight recent work examining sex differences in the molecular mechanisms of BP control in hypertension to assess whether the “one-size-fits-all” approach to BP control is appropriate with regard to sex.
Enterococcus faecalisEndogenous Endophthalmitis from Valvular Endocarditis
Authors: Barge Sidnei , Rothwell Renata , Varandas Rosário , Agrelos Luís
Published: July 2013

We report a case of a 74-year-old female, with a mitral heart valve, who presented with pain and blurred vision in the right eye for 2 days. Her visual acuity was light perception (LP) in the right eye and 20/40 in the left eye. Slit lamp examination showed corneal edema and hypopyon, and a view of the right fundus was impossible. Echography showed vitreous condensation. One day after presentation, the patient developed acute lung edema requiring hospitalization, so she was not submitted to vitreous tap and intravitreal treatment. The cardiac and systemic evaluations revealed a mitral endocarditis secondary toEnterococcus faecalis. The patient improved systemically with treatment with gentamicin, vancomycin, and linezolid. Her visual acuity remained as no LP, and her intraocular pressure (IOP) has been controlled with brimonidine bid despite developing a total cataract with 360° posterior synechia. A cardiac source for endogenous endophthalmitis should be considered in the presence of a prosthetic cardiac valve. The treatment and followup must be made in cooperation with a cardiologist specialist, but the ophthalmologist can play a key role in the diagnosis.
Diabetic Mastopathy: An Uncommon Complication of Diabetes Mellitus
Authors: Kirby R. X. , Mitchell D. I. , Williams N. P. , Cornwall D. A. , Cawich S. O.
Published: July 2013

Introduction. Whilst most consequences of diabetes mellitus are well recognized, breast-related complications remain obscure. The term diabetic mastopathy (DMP) attempts to describe the breast-related consequences of diabetes.Methods. We report the clinicopathologic findings in a patient with DMP and review the literature on this uncommon entity.Results. A 33-year-old woman with type 1 diabetes had excision biopsy of a 2 cm breast lump. Histopathologic evaluation revealed classic features of DMP: parenchymal fibrosis; keloid-like hyalinization of interlobular stroma; adipose tissue entrapment; lobular compression; dense chronic inflammatory cell infiltration; and lymphoid follicle formation.Conclusion. Clinicians should be aware of DMP as a differential for breast disease in women with uncontrolled diabetes.
Primary Plasmacytoma of the Kidney
Authors: Spence R. A. J. , Thwaini A. , O'Rourke D. M.
Published: July 2013

Primary renal plasmacytomas are an extremely rare clinical condition. Their management is particularly challenging due to the paucity of evidence, with only just over a dozen previously reported cases. We report a case of a primary extramedullary plasmacytoma of the kidney and performed a review of the literature. The case is presented as a learning point that it is imperative to keep plasmacytic tumours in mind and to include them in the differential diagnosis of anaplastic tumours, even in unusual locations, such as the kidney.
Spontaneous Coronary Artery Dissection in a Male Patient with Takayasu’s Arteritis and Antiphospholipid Antibody Syndrome
Authors: Gerede Demet Menekşe , Yüksel Bağdagül , Tutar Eralp , Küçükşahin Orhan , Uzun Çağlar , Atasoy Kayhan Çetin , Düzgün Nurşen , Bengisun Uğur
Published: July 2013

We present a case of a 34-year-old male who presented to the emergency ward with fever and abdominal pain. The diagnosis of Takayasu’s arteritis and also antiphospholipid syndrome was made during an imaging workup of deep-vein thrombosis. A spontaneous coronary artery dissection was revealed in coronary CT angiography requested for chest pain and dyspnea. The patient was treated medically and discharged on close followup. The concurrence of spontaneous coronary artery dissection with antiphospholipid syndrome and Takayasu’s arteritis has not been reported in the previous literature. The possibility of a spontaneous coronary artery dissection should be considered in patients presenting with both diseases.
A Rare Neurological Complication of Ranolazine
Authors: Porhomayon Jahan , Zadeii Gino , Yarahmadi Alireza
Published: July 2013

Myoclonus is not a known side effect of ranolazine. We report a case of myoclonus in a 72-year-old female who underwent cardiac catheterization for angina and was started on ranolazine after the procedure. Two days after ranolazine therapy on 1000 mg per day in divided doses, myoclonus developed, which severely impaired her normal activity. Her symptoms resolved 2 days after discontinuation of ranolazine. Ranolazine was resumed after discharge from hospital with recurrent myoclonus after two days of therapy. The causal relationship between ranolazine and myoclonus was suggested by cessation of myoclonus after ranolazine was discontinued.
Solubility and Leaching Risks of Organic Carbon in Paddy Soils as Affected by Irrigation Managements
Authors: Xu Junzeng , Yang Shihong , Peng Shizhang , Wei Qi , Gao Xiaoli
Published: July 2013

Influence of nonflooding controlled irrigation (NFI) on solubility and leaching risk of soil organic carbon (SOC) were investigated. Compared with flooding irrigation (FI) paddies, soil water extractable organic carbon (WEOC) and dissolved organic carbon (DOC) in NFI paddies increased in surface soil but decreased in deep soil. The DOC leaching loss in NFI field was 63.3 kg C ha−1, reduced by 46.4% than in the FI fields. It indicated that multi‐wet‐dry cycles in NFI paddies enhanced the decomposition of SOC in surface soils, and less carbon moved downward to deep soils due to less percolation. That also led to lower SOC in surface soils in NFI paddies than in FI paddies, which implied that more carbon was released into the atmosphere from the surface soil in NFI paddies. Change of solubility of SOC in NFI paddies might lead to potential change in soil fertility and sustainability, greenhouse gas emission, and bioavailability of trace metals or organic pollutants.
The Role of Phenytoin in the Treatment of Localization Related Epilepsy: An International Internet-Based Survey of Neurologists and Epileptologists
Authors: Das Rohit R. , Griesemer David A. , Kothare Sanjeev V.
Published: July 2013

Phenytoin (PHT) has been the most widely used medication to treat both partial and generalized seizures. However, over the past twenty years, a variety of new compounds have been released with comparable efficacy, fewer adverse effects, and more predictable pharmacokinetic properties. We surveyed neurologists and epileptologists to determine current practice patterns relating to the use of PHT using an online survey instrument. A total of 200 responses were obtained though response rates for each survey question varied. Of the respondents, 78.1% were epilepsy specialists; 60% were adult practitioners; and the remainder saw either, only children or both adults and children. For new onset partial seizures only 10 respondents said PHT would be their first or second choice, while 45% reported that they would not consider PHT. This study shows that in the era of newer medications, the role of PHT has been placed in the category of a reserve medication in intractable epilepsy.
Isoflavonoid-RichFlemingia macrophyllaExtract Attenuates UVB-Induced Skin Damage by Scavenging Reactive Oxygen Species and Inhibiting MAP Kinase and MMP Expression
Authors: Chiang Hsiu-Mei , Chiu Hua-Hsien , Liao Sue-Tsai , Chen Yen-Ting , Chang Hsien-Chang , Wen Kuo-Ching
Published: July 2013

In this study, we investigated the antioxidant activity and anti-photoaging properties of an extract ofFlemingia macrophylla, a plant rich in isoflavonoid content. Pretreatment of fibroblasts withFlemingia macrophyllaextract (FME) inhibited elastase activity, promoted the protein expression of type I procollagen, and attenuated the phosphorylation of mitogen-activated protein (MAP) kinase and the protein expression of matrix-metalloproteinase- (MMP-) 1, 3, and 9. The IC50values were 2.1 μg/mL for DPPH radical scavenging ability, 366.8 μg/mL for superoxide anion scavenging ability, 178.9 μg/mL for hydrogen peroxide scavenging ability, and 230.9 μg/mL for hydroxyl radical scavenging ability. Also, exposure of erythrocytes to various concentrations of FME (50–500 μg/mL) resulted in a dose- and time-dependent inhibition of AAPH-induced hemolysis. In human fibroblasts, FME at 10 μg/mL was shown to be a potent scavenger of UV-induced reactive oxygen species (ROS). The antioxidant and anti-photoaging properties of FME make it an ideal anti-intrinsic aging and anti-photoaging agent.
PET/MRI Imaging in High-Risk Sarcoma: First Findings and Solving Clinical Problems
Authors: Schuler Markus K. , Richter Stephan , Beuthien-Baumann Bettina , Platzek Ivan , Kotzerke Jörg , van den Hoff Jörg , Ehninger Gerhard , Reichardt Peter
Published: July 2013

Simultaneous positron emission tomography (PET) and magnetic resonance imaging (MRI) is a new whole-body hybrid PET/MR imaging technique that combines metabolic and cross-sectional diagnostic imaging. Since the use of MRI in imaging of soft-tissue sarcoma is extremely beneficial, investigation of the combined PET/MRI is of great interest. In this paper, we present three cases and first data. Combined PET/MRI technique can support the process of clinical decision-making and give answers to some meaningful questions when treating patients with STS. Therefore, the combined modality of simultaneous PET/MRI offers new pieces to the puzzle of sarcoma treatment.
Nanocomposites Based on PLLA and Multi Walled Carbon Nanotubes Support the Myogenic Differentiation of Murine Myoblast Cell Line
Authors: Montesano Simona , Lizundia Erlantz , D'Angelo Francesco , Fortunati Elena , Mattioli Samantha , Morena Francesco , Bicchi Ilaria , Naro Fabio , Sampaolesi Maurilio , Sarasua Josè Ramon , Kenny Josè Maria , Orlacchio Aldo , Armentano Ilaria , Martino Sabata
Published: July 2013

We explored the effect of poly(L-lactic acid) (PLLA) containing various percentages (0.1, 0.5, 1, and 3 wt.%) of multi walled carbon nanotubes (MWCNTs) on the myogenic differentiation of C2C12 murine myoblast progenitor cells. We showed that all PLLA/MWCNTs nanocomposite materials support the myotubes formation more efficiently than neat PLLA as indicated by the high expression of the most significant myogenic markers: MyoD, Myosin Heavy Chain, dimension of myofibres, and fusion myogenic index. Interestingly, we note that both MyoD and myogenic fusion index levels were in the order 0.1 MWCNTs = 0.5 MWCNTs > 1 MWCNTs > 3 MWCNTs > neat PLLA, suggesting that the amount of MWCNTs influenced the cell differentiation.
Dynamic Downscaling of the Impact of Climate Change on the Ocean Circulation in the Galápagos Archipelago
Authors: Liu Yanyun , Xie Lian , Morrison John M. , Kamykowski Daniel
Published: July 2013

The regional impact of global climate change on the ocean circulation around the Galápagos Archipelago is studied using the Hybrid Coordinate Ocean Model (HYCOM) configured for a four-level nested domain system. The modeling system is validated and calibrated using daily atmospheric forcing derived from the NCEP/NCAR reanalysis dataset from 1951 to 2007. The potential impact of future anthropogenic global warming (AGW) in the Galápagos region is examined using the calibrated HYCOM with forcing derived from the IPCC-AR4 climate model. Results show that although the oceanic variability in the entire Galápagos region is significantly affected by global climate change, the degree of such effects is inhomogeneous across the region. The upwelling region to the west of the Isabella Island shows relatively slower warming trends compared to the eastern Galápagos region. Diagnostic analysis suggests that the variability in the western Galápagos upwelling region is affected mainly by equatorial undercurrent (EUC) and Panama currents, while the central/east Galápagos is predominantly affected by both Peru and EUC currents. The inhomogeneous responses in different regions of the Galápagos Archipelago to future AGW can be explained by the incoherent changes of the various current systems in the Galápagos region as a result of global climate change.
Nonsmall Cell Lung Cancer Therapy: Insight into Multitargeted Small-Molecule Growth Factor Receptor Inhibitors
Authors: Roy Mridul , Luo Yu-Hao , Ye Mao , Liu Jing
Published: July 2013

To date, lung cancer is the leading cause of cancer-related death worldwide, among which nonsmall cell lung cancer (NSCLC) comprises about 85%. Taking into account the side effects of surgery, radiation, platinum-based doublet chemotherapy, and the growth self-sufficiency characteristic of cancer cells, drugs have been discovered toward growth factor receptor (GFR) to treat NSCLC. As expected, these drugs provide a greater benefit. To increase the efficacy of such growth factor receptor tyrosine kinase inhibitors (RTKIs), coinhibition of GFR signaling pathways and combination of inhibitors along with radiation or chemotherapy have drew intense insight. Although clinical trials about single-agent RTKIs or their combination strategies suggest their increase potency against cancer, they are not beyond adverse effects, and sometimes the effects are more deadly than chemotherapy. Nevertheless the hope for RTKIs may be proved true by further researches and digging deep into cancer therapeutics.
Diagnostic Value of Dynamics Serum sCD163, sTREM-1, PCT, and CRP in Differentiating Sepsis, Severity Assessment, and Prognostic Prediction
Authors: Su Longxiang , Feng Lin , Song Qing , Kang Hongjun , Zhang Xingang , Liang Zhixin , Jia Yanhong , Feng Dan , Liu Changting , Xie Lixin
Published: July 2013

Objective. To describe the dynamics changes of sCD163, soluble serum triggering receptor expressed on myeloid cells-1 (sTREM-1), procalcitonin (PCT), and C-reactive protein (CRP) during the course of sepsis, as well as their outcome prediction.Patients and Methods. An SIRS group (30 cases) and a sepsis group (100 cases) were involved in this study. Based on a 28-day survival, the sepsis was further divided into the survivors’ and nonsurvivors’ groups. Serum sTREM-1, sCD163, PCT, CRP, and WBC counts were tested on days 1, 3, 5, 7, 10, and 14.Results. On the ICU admission, the sepsis group displayed higher levels of sTREM-1, sCD163, PCT, and CRP than the SIRS group (P<0.05). Although PCT and sTREM-1 are good markers to identify severity, sTREM-1 is more reliable, which proved to be a risk factor related to sepsis. During a 14-day observation, sCD163, sTREM-1, PCT, and SOFA scores continued to climb among nonsurvivors, while their WBC and CRP went down. Both sCD163 and SOFA scores are risk factors impacting the survival time.Conclusion. With regard to sepsis diagnosis and severity, sTREM-1 is more ideal and constitutes a risk factor. sCD163 is of a positive value in dynamic prognostic assessment and may be taken as a survival-impacting risk factor.
Effects of Levetiracetam Monotherapy on the Cognitive Function of Epilepsy Patients
Authors: Koo Dae Lim , Hwang Kyoung Jin , Kim Daeyoung , Kim You-Jin , Kim Ji Young , Shin Wonchul , Kim Mi Rim , Joo Eun Yeon , Lee Jong-Min , Hong Seung Bong
Published: July 2013

Aims: To estimate the effect of levetiracetam (LEV) on cognitive function and mood status in newly diagnosed epilepsy patients. Methods: Fifty-five drug-naïve epilepsy patients (M:F ratio = 31:24; mean age = 30.9 years) were included. All patients underwent two neuropsychological (NP) tests, one before receiving LEV and then another 12.9 ± 5.0 months after starting LEV monotherapy. We evaluated general cognitive function, verbal/visual attention and memory, linguistic and visuospatial functions, frontal lobe function, and mood status. Repeated-measures regression and generalized estimating equation models were applied to assess the effects of all the confounding variables such as seizure control, average LEV dose, duration of epilepsy, inter-test interval, and subtype of epilepsy syndrome. Results: LEV monotherapy over 1 year revealed significant improvements in the following domains of NP tests with the correction of possible confounding variables: verbal and visual attention, psychomotor speed, mental flexibility, executive function, verbal fluency and word generation. No NP domains showed any significant decrease. Conclusion: Our study suggested that LEV monotherapy had no harmful effect on cognitive function in drug-naïve patients with epilepsy.
Unexpected Distribution of cKIT and BRAF Mutations among Southern Italian Patients with Sinonasal Melanoma
Authors: Colombino Maria , Lissia Amelia , Franco Renato , Botti Gerardo , Ascierto Paolo A. , Manca Antonella , Sini Maria Cristina , Pisano Marina , Paliogiannis Panagiotis , Tanda Francesco , Palmieri Giuseppe , Cossu Antonio
Published: July 2013

Background: Racial and geographic factors seem to affect the incidence of cutaneous and mucosal melanoma. Objective: To investigate the occurrence of BRAF and cKIT impairments in patients with sinonasal melanoma in Southern Italy. Methods: Eleven sinonasal melanomas were screened for BRAF mutations and cKIT alterations by immunohistochemistry (CD117), fluorescence in situ hybridization and sequencing analyses. Results: A high prevalence (4/11; 36%) of BRAF mutations and lack of cKIT mutations were observed. Amplification of cKIT was found in 18% of cases; cKIT expression was detectable in 18% non-overlapping cases. No correlation between CD117 and cKIT alterations was observed. One (6%) cKIT and two (12%) BRAF mutations were detected in an additional series of 17 acral/mucosal melanomas from the same geographic areas. Conclusion: Mutations of cKIT are infrequent in sinonasal melanoma in Southern Italy.
Feasibility Study of Adjuvant Chemotherapy of S-1 and Carboplatin for Completely Resected Non-Small Cell Lung Cancer
Authors: Komazaki Yoshitoshi , Sakashita Hiroyuki , Furuiye Masashi , Fujie Toshihide , Tamaoka Meiyo , Sumi Yuki , Miyazaki Yasunari , Kojima Katsuo , Jin Yasuto , Inase Naohiko
Published: July 2013

Background: The purpose of this study was to evaluate the feasibility and compliance of adjuvant chemotherapy of S-1 plus carboplatin for patients with completely resected non-small cell lung cancer (NSCLC) of pathological stage IB-IIIB. Methods: S-1 was given orally at a dose of 80 mg/m2/day for 2 weeks, followed by a 2-week period of no treatment. Carboplatin was given intravenously on day 8 at an area under the curve of 6. This regimen was repeated for four to six 28-day courses. Results: Seventeen patients were enrolled in this study. Fourteen of them completed at least 4 cycles of chemotherapy. Nine patients had grade 2 and three patients had grade 3 thrombocytopenia, respectively. Severe nonhematologic toxicities were uncommon. Treatment was delayed in a few patients because of prolonged thrombocytopenia. Conclusion: We concluded that the regimen was feasible and tolerable for patients with completely resected NSCLC as adjuvant chemotherapy.
Effects of Combined Treatment with Ambroxol and Ciprofloxacin on Catheter-Associated Pseudomonas aeruginosa Biofilms in a Rat Model
Authors: Lu Qi , Yu JiaLin , Bao Lei , Ran Tao , Zhong Haiying
Published: July 2013

Background:Pseudomonas aeruginosa is an opportunistic pathogen that causes potentially devastating infections in immunocompromised patients. These infections are particularly difficult to treat if a biofilm forms, which is likely if foreign bodies are present. Objective: This study aimed to investigate the effect of ambroxol combined with ciprofloxacin on P. aeruginosa biofilm in a rat model. Methods: A rat model of acute lung infection was created by endotracheal (ET) intubation with a tube covered with a P. aeruginosa biofilm. The rats were treated with ciprofloxacin alone, ambroxol alone, or a combination of both for 7 days. The microstructure of the biofilm on the tube was assessed by scanning electron microscopy (SEM). The numbers of bacterial colonies in the lungs and on the ET tube were measured on agar plates. Pathological changes in the lungs were observed with hematoxylin and eosin staining. Results: Changes in the microstructure of the biofilm after combined treatment were demonstrated by SEM. Ambroxol combined with ciprofloxacin significantly reduced the number of bacteria in the lungs and ET tube compared to the single treatments (p < 0.05). The pathological changes in the lungs were also mildest after the combined treatment. Conclusion: The combination treatment of ambroxol with ciprofloxacin has a high ability to eradicate P. aeruginosa biofilms in vivo. These initial results provide the basis of a new strategy for the treatment of P. aeruginosa infections.
Pirfenidone Attenuates Cardiac Fibrosis in a Mouse Model of TAC-Induced Left Ventricular Remodeling by Suppressing NLRP3 Inflammasome Formation
Authors: Wang Yongliang , Wu Yongquan , Chen Jiawei , Zhao Shumei , Li Hongwei
Published: July 2013

Objectives: Left ventricular remodeling is a frequent complication of hypertension with no therapeutic treatment available for the subsequent onset of myocardial fibrosis. Pirfenidone is an antifibrotic small-molecular-size drug with anti-inflammatory properties that is used as a treatment for fibrotic diseases, but its effects on hypertension-induced myocardial fibrosis are unknown. Therefore, we tested whether pirfenidone could ameliorate hypertension-induced left ventricular remodeling and whether hypertension-induced NLRP3 (Nod-like receptor pyrin domain containing 3), a critical protein in NLRP3 inflammasome formation, is involved in the therapeutic mechanism. Methods: A TAC-induced mouse model of hypertension and left ventricular hypertrophy was treated with pirfenidone, and survival, collagen deposition by histopathologic examination, heart function by echocardiography, concentrations of fibrosis-related inflammatory cytokines TGF-β1, IL-1β in heart homogenate and in vitro cell cultures by ELISA, levels of ROS and inflammatory cells by flow cytometry, and levels of NLRP3 by Western blotting and immunohistochemistry were measured. Results: Pirfenidone increased the survival rate and attenuated myocardial fibrosis and inflammatory mediators in the TAC-induced hypertension-complicated left ventricular remodeling mouse model. The inhibition of NLRP3 expression by pirfenidone attenuated the expression of IL-1β and IL-1β-induced inflammatory and profibrotic responses. Conclusions: Pirfenidone may be useful in the treatment of hypertension-induced myocardial fibrosis by inhibiting NLRP3-induced inflammation and fibrosis.
Endovascular Treatment of Cervical Artery Dissection: Ten Case Reports and Review of the Literature
Authors: Ahlhelm Frank , Benz Robyn Melanie , Ulmer Stephan , Lyrer Philippe , Stippich Christoph , Engelter Stefan
Published: July 2013

Purpose: The role of endovascular treatment in cases of cervical artery dissection (CeAD) is debatable. With an increasing number of endovascular therapies such as endovascular recanalization and embolization the number of complications such as iatrogenic dissection is also rising. We report our experience with endovascular stenting in the treatment of patients presenting with CeAD. Methods: We included all consecutive patients with CeAD (n = 168) treated in our hospital between 2001 and 2010 for our retrospective study. Patients with CeAD were considered eligible for stenting: (1) in iatrogenic dissections and (2) in noniatrogenic dissections if they suffered from recurrent ischemic events despite antithrombotic treatment. Results: During our observation period 10 out of 168 patients presenting with CeAD were selected for stenting. Several types of stents were used. Stenting was technically successful in 8 but unsuccessful in 2 patients with complete arterial occlusion. Stent-related clinically apparent complications occurred in 3 of the 10 patients. All were transient. During a mean follow-up of 47 (±24.8) months none of the patients had new cerebrovascular ischemic events. Conclusion: In our patient sample stenting due to dissection is a rare procedure performed in less than 10% of CAD patients. It should be considered as a feasible rescue treatment in cases of impending stroke despite optimal antithrombotic therapy.
Management of Brain Metastases from Germ Cell Tumors: A Single Center Experience
Authors: Boyle H.J. , Jouanneau E. , Droz J.P. , Fléchon A.
Published: July 2013

Background: Brain metastases from germ cell tumors (GCT) are rare and treatment has not yet been standardized. Methods: The clinical data of men with brain metastases from GCT treated in a single cancer hospital from January 1993 to September 2007 were reviewed. Patients with primary central nervous system GCT were excluded. Results: Thirteen patients had brain metastases at initial diagnosis. All patients received cisplatin-based chemotherapy. Three also received radiotherapy and 1 underwent surgery. Eight of the patients died. Median survival was 19 months (95% CI 0.84-not reached). Twenty-two patients developed brain metastases at recurrence. Median time from initial diagnosis to brain metastases was 8.25 months (3-17.5 months). Five patients received radiotherapy alone, 3 received chemotherapy alone and 3 received supportive care only. Nine patients were operated on: 6 received postoperative chemotherapy and 1 received postoperative radiotherapy. Only 1 patient is still alive. Median survival was 5.1 months (95% CI: 2.2-10.5 months). Conclusions: Patients with GCT who present with brain metastases at diagnosis tend to do better than patients who develop them at relapse. Chemotherapy can be adequate treatment for initial brain metastases. Treatment for patients with brain metastases at relapse is still not optimal.
Iron Homeostasis and Serum Hepcidin-25 Levels in Obese Children and Adolescents: Relation to Body Mass Index
Authors: Hamza Rasha T. , Hamed Amira I. , Kharshoum Reham R.
Published: July 2013

Background/Aims: The etiology of the hypoferremia of obesity is unclear. Hepcidin is the body's main regulator of systemic iron (Fe) and has been reported to be elevated in obese patients. Thus, we aimed to assess Fe status and serum hepcidin-25 levels and their relationship with body mass index (BMI) in obese Egyptian children and adolescents. Methods: Fifty obese children were compared to 50 age-, sex- and pubertal stage- matched controls. All subjects were subjected to history and anthropometric assessment and measurement of serum Fe, total iron binding capacity (TIBC), ferritin, transferrin saturation (TS), soluble transferrin receptor (sTfR) and hepcidin. Results: Fe, TS and TIBC were lower, while ferritin, sTfR and hepcidin-25 were higher in obese patients than controls. BMI standard deviation score (SDS) correlated negatively with Fe (r = -0.82, p < 0.01), TS (r = -0.79, p = 0.02) and TIBC (r = -0.69, p = 0.02), and positively with ferritin (r = +0.73, p < 0.001), sTfR (r = +0.80, p < 0.01) and hepcidin (r = +0.95, p < 0.001). Higher BMI SDS and hepcidin were risk factors for iron deficiency (ID). Conclusions: Hypoferremia and elevated hepcidin-25 are prevalent in obese children and correlated with BMI SDS. The connection between hepcidin and inflammation could explain the association of ID with obesity.
Acute Porphyria Presenting as Epilepsia Partialis Continua
Authors: Tran Thi Phuoc Yen , Leduc Karine , Savard Martin , Dupré Nicolas , Rivest Donald , Nguyen Dang Khoa
Published: July 2013

Purpose: The porphyrias are a defect in the biosynthesis of heme which can be associated with different neurological symptoms during acute attacks such as peripheral neuropathy, mental disturbance and seizures. So far, there have only been a few case reports of status epilepticus, none of which were of epilepsia partialis continua (EPC). We present here two cases of hereditary coproporphyria (HCP) manifesting EPC as part of the clinical presentation. Method: The patients' medical charts, EEG and imaging studies were carefully reviewed. Results: Case 1 is a 49-year-old male who first presented a tonic-clonic seizure. Case 2 is a 30-year-old male who came to the emergency room for a convulsive status epilepticus. Both evolved to EPC over the next days. EPC persisted despite several antiepileptic drug trials. Diagnosis of HCP was confirmed by a high level of urine, fecal and serum porphyrins in both cases and by genetic testing in one. Over the last 3 years, the first patient has continued to present non-disabling EPC and has had four tonic-clonic seizures associated with alcohol consumption. The second patient died from brain edema one month and half after admission. Conclusion: Acute porphyrias should be included in the differential diagnosis of new onset status epilepticus, including EPC. Their recognition is important as it modifies significantly patient management, since many anticonvulsants are porphyrogenic.
Mechanisms of Banner Cloud Formation
Authors: Voigt Matthias , Wirth Volkmar
Published: July 2013

Banner clouds are clouds in the lee of steep mountains or sharp ridges. Their formation has previously been hypothesized as due to three different mechanisms: (i) vertical uplift in a lee vortex (which has a horizontal axis), (ii) adiabatic expansion along quasi-horizontal trajectories (the so-called Bernoulli effect), and (iii) a mixing cloud (i.e., condensation through mixing of two unsaturated air masses).

In the present work, these hypotheses are tested and quantitatively evaluated against each other by means of large-eddy simulation. The model setup is chosen such as to represent idealized but prototypical conditions for banner cloud formation. In this setup the lee-vortex mechanism is clearly the dominant mechanism for banner cloud formation. An essential aspect is the pronounced windward–leeward asymmetry in the Lagrangian vertical uplift with a plume of large positive values in the immediate lee of the mountain; this allows the region in the lee to tap moister air from closer to the surface. By comparison, the horizontal pressure perturbation is more than two orders of magnitude smaller than the pressure drop along a trajectory in the rising branch of the lee vortex; the “Bernoulli mechanism” is, therefore, very unlikely to be a primary mechanism. Banner clouds are unlikely to be “mixing clouds” in the strict sense of their definition. However, turbulent mixing may lead to small but nonnegligible moistening of parcels along time-mean trajectories; although not of primary importance, the latter may be considered as a modifying factor to existing banner clouds.
Assimilating AMSU-A Radiances in the TC Core Area with NOAA Operational HWRF (2011) and a Hybrid Data Assimilation System: Danielle (2010)
Authors: Zhang Man , Zupanski Milija , Kim Min-Jeong , Knaff John A.
Published: July 2013

A regional hybrid variational–ensemble data assimilation system (HVEDAS), the maximum likelihood ensemble filter (MLEF), is applied to the 2011 version of the NOAA operational Hurricane Weather Research and Forecasting (HWRF) model to evaluate the impact of direct assimilation of cloud-affected Advanced Microwave Sounding Unit-A (AMSU-A) radiances in tropical cyclone (TC) core areas. The forward components of both the gridpoint statistical interpolation (GSI) analysis system and the Community Radiative Transfer Model (CRTM) are utilized to process and simulate satellite radiances. The central strategies to allow the use of cloud-affected radiances are (i) to augment the control variables to include clouds and (ii) to add the model cloud representations in the observation forward models to simulate the microwave radiances. The cloudy AMSU-A radiance assimilation in Hurricane Danielle's (2010) core area has produced encouraging results with respect to the operational cloud-cleared radiance preprocessing procedures used in this study. Through the use of the HVEDAS, ensemble covariance statistics for a pseudo-AMSU-A observation in Danielle's core area show physically meaningful error covariances and statistical couplings with hydrometeor variables (i.e., the total-column condensate in Ferrier microphysics). The cloudy radiance assimilation in the TC core region (i.e., ASR experiment) consistently reduced the root-mean-square errors of the background departures, and also generally improved the forecasts of Danielle's intensity as well as the quantitative cloud analysis and prediction. It is also indicated that an entropy-based information content quantification process provides a useful metric for evaluating the utility of satellite observations in hybrid data assimilation.
The Emerging ‘Health Care Industry’ in India: A Public Health Perspective
Authors: Chakravarthi Indira
Published: July 2013

Corporate hospitals are becoming a significant presence within the ‘health care’ industry in India. There is strong advocacy and promotion by the industry, and the government, of the idea that health care infrastructure should not just be viewed as a social good but also as a viable economic venture with productivity. Yet, the discourse on privatisation, on the public–private divide in health systems does not pay attention to the spread of corporate sector activities and corporate financing in health care; to the increasing commercialisation of health services. This brief note highlights some recent trends and features of the hospitals sector of the ‘health care industry’ in India. There is a need to document and analyse the practices and behaviour of the hospital industry, and examine the impact of these changes for the public health systems, for policy and planning in public health, from a critical public health perspective.
Book Review: Muslim Becoming: Aspirations and Skepticism in Pakistan
Authors: Jalil Rakhshanda
Published: July 2013

Naveeda Khan, Muslim Becoming: Aspirations and Skepticism in Pakistan, New Delhi, Orient Black Swan, 2012.
Country Road Take Me Home
Authors: Betz Michael R. , Partridge Mark D.
Published: July 2013

This research fills a void in the regional development literature by assessing how labor force migration affects regional adjustment in peripheral regions and whether it differs from the rest of the country. We do this by comparing patterns for the lagging Appalachian region to the United States as a whole for the 1990s and post-2000 periods. We appraise whether successful job creation helps the original residents seeking employment, or primarily goes to outsiders, rendering place-based development policy ineffective. In a novel addition, we appraise whether local job creation is associated with attracting relatively wealthier net migrants. Because different relative migration elasticities imply different responses for other labor market outcomes, we also assess whether employment growth supports original residents in terms of lifting median household incomes and employment/population rates and reducing unemployment rates and poverty rates. We find that migration post-2000 has become less responsive to employment growth differentials, which allows successful economic development to lift the employment prospects of original resident and produces a stronger response in reducing local poverty rates.
The involvement of CD36 in monocyte activation by antiphospholipid antibodies
Authors: Kato M , Atsumi T , Oku K , Amengual O , Nakagawa H , Fujieda Y , Otomo K , Horita T , Yasuda S , Koike T
Published: July 2013

Background

CD36, known as a scavenger receptor, is a transmembrane glycoprotein expressed on monocytes, platelets and endothelial cells, recognizes multiple ligands, including phosphatidylserine, and regulates atherogenesis and thrombosis. The objective of this study is to investigate the possible involvement of CD36 in the pathophysiology of thrombosis in patients with antiphospholipid syndrome (APS).

Methods

First, rs3765187, a missense mutation linked to CD36 deficiency, was investigated by TaqMan polymerase chain reaction (PCR) genotyping method in 819 Japanese, including 132 patients with APS, 265 with systemic lupus erythematosus (SLE) in the absence of APS, and 422 healthy subjects. Then, the involvement of CD36 in antiphospholipid antibody (aPL)-induced tissue factor (TF) expression was examined using CD36-null mice or anti-CD36. Purified IgG from patients with APS and a monoclonal phosphatidylserine-dependent antiprothrombin antibody were used in these experiments. TF expression was tested by real-time PCR and flow cytometry.

Results

Minor allele carrier of rs3765187 was less frequent in patients with APS (3.8% p = 0.032), but not in patients with SLE in the absence of APS (7.9% p = 0.32), compared with healthy subjects (10.2%). The aPL-induced TF expression was significantly suppressed on peritoneal macrophages from CD36-null mice compared to wild type and significantly inhibited by anti-CD36 on human monocytes.

Conclusions

The gene mutation linked to CD36 deficiency was less frequent in patients with APS. The deficient or suppressed CD36 function significantly reduced aPL-induced TF expression in vitro. Taken together, in a susceptible background CD36 scavenger receptor function may be involved in the thrombotic pathophysiology in patients with APS.
Genome-wide identification and expression analysis of calcium-dependent protein kinase in maize
Authors: Kong Xiangpei , Lv Wei , Jiang Shanshan , Zhang Dan , Cai Guohua , Pan Jiaowen , Li Dequan
Published: July 2013

Background

Calcium-dependent protein kinases (CDPKs) have been shown to play important roles in various physiological processes, including plant growth and development, abiotic and biotic stress responses and plant hormone signaling in plants.

Results

In this study, we performed a bioinformatics analysis of the entire maize genome and identified 40 CDPK genes. Phylogenetic analysis indicated that 40 ZmCPKs can be divided into four groups. Most maize CDPK genes exhibited different expression levels in different tissues and developmental stages. Twelve CDPK genes were selected to respond to various stimuli, including salt, drought and cold, as well as ABA and H2O2. Expression analyses suggested that maize CDPK genes are important components of maize development and multiple transduction pathways.

Conclusion

Here, we present a genome-wide analysis of the CDPK gene family in maize for the first time, and this genomic analysis of maize CDPK genes provides the first step towards a functional study of this gene family in maize.