bluuebunny/crossref_metadata_2025 huggingface dataset:
Residual dizziness after BPPV management: exploring pathophysiology and treatment beyond canalith repositioning maneuvers
Authors: Özgirgin O. Nuri , Kingma Herman , Manzari Leonardo , Lacour Michel
Published: May 2024

Despite the high success rate of canalith repositioning maneuvers (CRMs) in the treatment of benign paroxysmal positional vertigo (BPPV), a growing number of patients report residual dizziness symptoms that may last for a significant time. Although the majority of BPPV cases can be explained by canalolithiasis, the etiology is complex. Consideration of the individual patient’s history and underlying pathophysiology of BPPV may offer the potential for treatment approaches supplementary to CRMs, as well as a promising alternative for patients in whom CRMs are contraindicated. This article provides a summary of the possible underlying causes of BPPV and residual dizziness, along with suggestions for potential management options that may be considered to relieve the burden of residual symptoms.
Balloon angiopLasty for intracranial Atherosclerotic minor Stroke/TIA (BLAST): study protocol for a multicenter prospective cohort study
Authors: Qi Shuang , Liu Liang , Yue Fei-Xue , Qiu Jing , Li Wei , Li Chao , Nguyen Thanh N. , Wei Ming , Chen Hui-Sheng , Wang Shou-Chun
Published: May 2024

Rationale/Aim

Intracranial atherosclerotic stenosis (ICAS) is a common cause of stroke in Asia and is significantly associated with stroke recurrence. The Balloon angiopLasty for intracranial Atherosclerotic minor Stroke/TIA (BLAST) study aims to evaluate the safety and effectiveness of early submaximal balloon angioplasty (SBA) combined with standard medical therapy vs. standard medical therapy alone in patients with minor stroke or transient ischemic attack (TIA) due to ICAS.

Methods

The BLAST study is a multicenter prospective cohort study which will enroll patients with minor stroke or TIA due to symptomatic ICAS within 1 week of symptom onset from 20 centers in China. Eligible patients will receive either SBA with standard medical therapy or standard medical therapy alone based on the decision of the patient or legal representative. Participants will be followed up for 1 year.

Study outcomes

The primary outcome is a composite of stroke or death within 30 days or ischemic stroke in the culprit artery territory from 30 days to 1 year. Secondary outcomes include stroke or death within 30 days, ischemic stroke in the culprit artery territory from 30 days to 1 year, restenosis rate of the culprit artery at 1 year, and neurological improvement at 90 days (assessed by mRS score). Safety outcomes include intracranial hemorrhage within 30 days and endovascular complications.

Sample size estimate

According to previous studies, the incidence of the composite clinical outcomes is 15% in the group receiving medical therapy alone. We assumed the incidence would decrease to 5% in the SBA combined with the medical therapy group. The target sample size is 416 patients (208 per group), with 90% power and 5% type I error, allowing for a 10% loss to follow-up.

Implications

The BLAST study will provide evidence regarding whether early SBA can reduce stroke recurrence and mortality in patients with minor stroke/TIA due to ICAS compared with medical therapy alone.

Clinical trial registration:Clinicaltrials.gov, NCT06014723.
Fine-tuning of mononuclear phagocytes for improved inflammatory responses: role of soybean-derived immunomodulatory compounds
Authors: Tezuka Hiroyuki , Imai Shinjiro
Published: May 2024

The concept of inflammation encompasses beneficial and detrimental aspects, which are referred to as infectious and sterile inflammations, respectively. Infectious inflammation plays a crucial role in host defense, whereas sterile inflammation encompasses allergic, autoimmune, and lifestyle-related diseases, leading to detrimental effects. Dendritic cells and macrophages, both of which are representative mononuclear phagocytes (MNPs), are essential for initiating immune responses, suggesting that the regulation of MNPs limits excessive inflammation. In this context, dietary components with immunomodulatory properties have been identified. Among them, soybean-derived compounds, including isoflavones, saponins, flavonoids, and bioactive peptides, act directly on MNPs to fine-tune immune responses. Notably, some soybean-derived compounds have demonstrated the ability to alleviate the symptom of allergy and autoimmunity in mouse models. In this review, we introduce and summarize the roles of soybean-derived compounds on MNP-mediated inflammatory responses. Understanding the mechanism by which soybean-derived molecules regulate MNPs could provide valuable insights for designing safe immunomodulators.
Management of iron deficiency anemia during pregnancy: a midwife-led continuity of care model
Authors: Naz Sabahat , Shahid Shahira , Noorani Sahir , Fatima Ishrat , Jaffar Ali , Kashif Muhammad , Yazdani Nida , Khan Uzma , Rizvi Arjumand , Nisar Muhammad Imran , Jehan Fyezah , Hoodbhoy Zahra
Published: May 2024

Background

Globally, 36.5% of pregnancies are affected by anemia, particularly in low-and middle-income countries, posing significant risks to maternal and perinatal health. In rural Pakistan, 44.3% of pregnant women suffer from iron deficiency, contributing to the high prevalence of anemia. Limited accessibility to antenatal care exacerbates the challenge, necessitating innovative solutions. This study assessed a midwife-led continuity of care model, utilizing intravenous (IV) iron therapy for the management of anemia in Karachi, Pakistan.

Methods

We performed a retrospective analysis of data from a prospective cohort study conducted in two primary healthcare facilities, which employed a community midwife (CMW)-led continuity of care model for antenatal care, including IV iron therapy. We extracted data from February 2021 to March 2022 for women who were diagnosed with anemia based on hemoglobin (Hb) levels, categorized as mild (10.0 to 10.9 g/dL), moderate (7.0 to 9.9 g/dL), or severe (less than 7.0 g/dL). Assessment occurred at the initial antenatal care (ANC) visit to establish baseline anemia severity, and approximately 2 weeks after intravenous (IV) iron therapy administration to evaluate post-treatment changes were considered.

Results

We enrolled 114 pregnant women, where the majority presented with moderate (88.6%) anemia. After IV iron treatment, 48.5% improved to normal-mild levels, while 50% remained unchanged. Severe anemia affected 10.5% at baseline; 42% shifted to moderate and 50% to normal-mild post-treatment, with one remaining unchanged (p < 0.001). Among women enrolled in the first and second trimesters, severe anemia improved to normal-mild (50%) and moderate levels (50%) (pre-treatment: n = 10, post-treatment: n = 0), and moderate anemia decreased by 48% (pre-treatment: n = 92, post-treatment: n = 47).

Conclusion

Our midwife-led model of care demonstrated an improvement in iron levels among pregnant women. The model addressed the challenges of anemia prevalence in Pakistan and underscored the significance of empowering front-line healthcare providers, such as community midwives (CMWs) for managing these common conditions.
Application value of 18F-FDG PET/CT in primary spleen angiosarcoma with liver metastasis: a case report and literature review
Authors: Shao Mingyan , Qi Wanling , Xu Rong , Luo Zhehuang , Liao Fengxiang , Fan Sisi
Published: May 2024

Background

Primary splenic angiosarcoma (PSA) is a rare neoplasm. It is a malignant tumor derived from endothelial cells of the splenic sinuses. PSA has an unknown etiology, a high degree of malignancy, easy early metastasis, atypical clinical symptoms and imaging findings, and difficult early diagnosis. This paper reports the 18F-FDG PET/CT findings of a case of PSA with intrahepatic metastasis; summarizes its clinical, imaging, and pathological data; and reviews the literature.

Case description

A 64-year-old male patient presented with left lower abdominal distending pain without obvious causes on 13 March 2022. The pain was persistent and dull and worsened after sitting and eating. Blood routine examination results were RBC ↓ 3.33 × 1012/L, WBC ↑ 12.32 × 109/L, and PLT ↓ 40 × 109/L. The tumor markers indicated CA125 ↑ 47.0 U/ml, AFP (−), CEA (−), CA199 (−), and CA724 (−). Non-contrast-enhanced CT scan of the abdomen showed that the spleen was significantly enlarged in volume and irregular in shape and had multiple nodules and clumpy low-density shadows, unclear boundaries, uneven density, and multiple necrotic areas. Enhanced CT showed diffuse uneven mild enhancement of the spleen, and the degree of enhancement increased with time. Multiple nodular low-density shadows were seen in the liver, which were slightly enhanced by the enhanced scan.18F-FDG PET/CT showed multiple nodular and massive lesions in the spleen with multiple necrotic areas. There were multiple nodular lesions in the liver, the level of FDG metabolism increased, the SUVmax of the spleen lesions was 9.0, and the SUVmax of the liver lesions was 5.6. The 18F-FDG PET/CT diagnosis was splenic malignancy with liver metastasis. Finally, after a multidisciplinary discussion, it was decided to perform laparoscopic total splenectomy and portal vein infusion chemotherapy. Pathological examination showed that the tumor cells were round, oval, or fusiform, with obvious atypia, arranged into a cable or anastomosed vascular lumen. The final diagnosis was primary splenic angiosarcoma with massive necrosis. After surgery, the patient received antitumor combined therapy and died 5 months later.

Conclusion

The incidence of PSA is very low, and its clinical and radiological manifestations lack specificity. 18F-FDG PET/CT imaging has a certain diagnostic value for PSA and significant utility in preoperative staging, guiding biopsy procedures, evaluating postoperative treatment response, and monitoring disease recurrence. PSA should be considered in the presence of a space-occupying lesion within the spleen that exhibits necrotic areas, shows progressive enhancement on contrast-enhanced scans, and demonstrates heterogeneous increases in FDG uptake.
Can adjuvant immune checkpoint inhibitors improve the long-term outcomes of hepatocellular carcinoma with high-risk recurrent factors after liver resection? A meta-analysis and systematic review
Authors: Hu Lingbo , Kong Yenan , Qiao Yingli , Wang Aidong
Published: May 2024

Background

Administering adjuvant therapy following liver resection is crucial for patients with hepatocellular carcinoma (HCC) exhibiting high-risk recurrence factors. Immune checkpoint inhibitors (ICIs) are effective against unresectable HCC; however, their effectiveness and safety for this specific patient group remain uncertain.

Methods

We conducted an extensive literature search across four scholarly databases to identify relevant studies. Our primary endpoints were overall survival (OS), recurrence-free survival (RFS), and adverse events (AEs). OS and RFS were quantified using hazard ratios (HRs), whereas the 1-, 2-, and 3-year OS and RFS rates were expressed as risk ratios (RRs). Additionally, the incidence of AEs was calculated.

Results

Our meta-analysis included 11 studies (N = 3,219 patients), comprising two randomized controlled trials (RCTs) and nine retrospective studies. Among these, eight studies reported HRs for OS, showing a statistically significant improvement in OS among patients receiving adjuvant ICIs (HR, 0.60; 95% confidence interval [CI], 0.45–0.80; p < 0.0001). All included studies reported HRs for RFS, indicating a favorable impact of adjuvant ICIs (HR, 0.62; 95% CI, 0.52–0.73; p < 0.0001). Moreover, aggregated data demonstrated improved 1- and 2-year OS and RFS rates with adjuvant ICIs. The incidence rate of AEs of any grade was 0.70 (95% CI, 0.49–0.91), with grade 3 or above AEs occurring at a rate of 0.12 (95% CI, 0.05–0.20).

Conclusion

Adjuvant ICI therapy can enhance both OS and RFS rates in patients with HCC exhibiting high-risk recurrence factors, with manageable AEs.

Systematic review registration

https://www.crd.york.ac.uk/prospero/#recordDetails PROSPERO, identifier CRD42023488250.
Case report: Regression after low-dose glucocorticoid therapy in a case of acute immune myocarditis induced by anti-PD-1 therapy for NSCLC
Authors: Chen Liqianqi , Zhang Suihao , Gong Long , Zhang Yucong
Published: May 2024

Background

PD-1 inhibitors exhibit efficacy in managing unresectable/metastatic driver gene-negative NSCLC, albeit with potential immune-related adverse events (irAEs). Among these, immune checkpoint inhibitor-associated myocarditis (ICI-M) is rare yet lethal. This study presents the initial successful instance of ICI-M in a lung cancer patient, rescued by low-dose glucocorticoids post-deterioration during treatment.

Case summary

A 78-year-old male with a medical history of stage IV pT3N2M1 NSCLC underwent four cycles of palliative chemotherapy, resulting in stable disease (SD). Subsequent to declining further chemotherapy, the patient was transitioned to a targeted therapy regimen comprising Anlotinib in conjunction with PD-1 inhibitor immunotherapy. On the 26th day post-administration of the PD-1 inhibitor, the patient manifested Grade 2 immune-mediated myocarditis. Treatment encompassing 1mg/kg methylprednisolone combined with immunoglobulin shock therapy was initiated for 3 days, achieving symptomatic control. Nonetheless, upon tapering methylprednisolone dosage to 4–8mg/3–4d, the condition deteriorated, necessitating transfer to the intensive care unit. Methylprednisolone dosage was escalated to 80mg/day for 3 days, followed by gradual reduction by one-third to two-thirds weekly, culminating in the patient’s safe discharge from the hospital.

Conclusion

Immune-related myocarditis linked to checkpoint inhibitors is often managed effectively with high-dose glucocorticoid therapy. However, in Asian populations, low-dose glucocorticoids are increasingly utilized for salvage therapy, yielding favorable outcomes and improving prognosis compared to European populations.
A role for curcumin in preventing liver fibrosis in animals: a systematic review and meta-analysis
Authors: Huang Bo-Hao , Guo Zi-Wei , Lv Bo-Han , Zhao Xin , Li Yan-Bo , Lv Wen-Liang
Published: May 2024

Objective

This meta-analysis aimed to determine the efficacy of curcumin in preventing liver fibrosis in animal models.

Methods

A systematic search was conducted on studies published from establishment to November 2023 in PubMed, Web of Science, Embase, Cochrane Library, and other databases. The methodological quality was assessed using Sycle’s RoB tool. An analysis of sensitivity and subgroups were performed when high heterogeneity was observed. A funnel plot was used to assess publication bias.

Results

This meta-analysis included 24 studies involving 440 animals with methodological quality scores ranging from 4 to 6. The results demonstrated that curcumin treatment significantly improved Aspartate aminotransferase (AST) [standard mean difference (SMD) = -3.90, 95% confidence interval (CI) (−4.96, −2.83), p < 0.01, I2 = 85.9%], Alanine aminotransferase (ALT)[SMD = − 4.40, 95% CI (−5.40, −3.40), p < 0.01, I2 = 81.2%]. Sensitivity analysis of AST and ALT confirmed the stability and reliability of the results obtained. However, the funnel plot exhibited asymmetry. Subgroup analysis based on species and animal models revealed statistically significant differences among subgroups. Furthermore, curcumin therapy improved fibrosis degree, oxidative stress level, inflammation level, and liver synthesis function in animal models of liver fibrosis.

Conclusion

Curcumin intervention not only mitigates liver fibrosis but also enhances liver function, while concurrently modulating inflammatory responses and antioxidant capacity in animal models. This result provided a strong basis for further large-scale animal studies as well as clinical trials in humans in the future.

Systematic Review Registration:https://www.crd.york.ac.uk/prospero/, identifier CRD42024502671.
Realizing the gravity of the simulation: adaptation to simulated hypogravity leads to altered predictive control
Authors: Rock Chase G. , Kwak Samuel T. , Luo Angela , Yang Xiao , Yun Kristy , Chang Young-Hui
Published: May 2024

Accurate predictive abilities are important for a wide variety of animal behaviors. Inherent to many of these predictions is an understanding of the physics that underlie the behavior. Humans are specifically attuned to the physics on Earth but can learn to move in other environments (e.g., the surface of the Moon). However, the adjustments made to their physics-based predictions in the face of altered gravity are not fully understood. The current study aimed to characterize the locomotor adaptation to a novel paradigm for simulated reduced gravity. We hypothesized that exposure to simulated hypogravity would result in updated predictions of gravity-based movement. Twenty participants took part in a protocol that had them perform vertically targeted countermovement jumps before (PRE), during, and after (POST) a physical simulation of hypogravity. Jumping in simulated hypogravity had different neuromechanics from the PRE condition, with reduced ground impulses (p ≤ .009) and muscle activity prior to the time of landing (i.e., preactivation; p ≤ .016). In the 1 g POST condition, muscle preactivation remained reduced (p ≤ .033) and was delayed (p ≤ .008) by up to 33% for most muscles of the triceps surae, reflecting an expectation of hypogravity. The aftereffects in muscle preactivation, along with little-to-no change in muscle dynamics during ground contact, point to a neuromechanical adaptation that affects predictive, feed-forward systems over feedback systems. As such, we conclude that the neural representation, or internal model, of gravity is updated after exposure to simulated hypogravity.
Regulatory mechanisms of plant rhizobacteria on plants to the adaptation of adverse agroclimatic variables
Authors: Verma Krishan K. , Joshi Abhishek , Song Xiu-Peng , Liang Qiang , Xu Lin , Huang Hai-rong , Wu Kai-Chao , Seth Chandra Shekhar , Arora Jaya , Li Yang-Rui
Published: May 2024

The mutualistic plant rhizobacteria which improve plant development and productivity are known as plant growth-promoting rhizobacteria (PGPR). It is more significant due to their ability to help the plants in different ways. The main physiological responses, such as malondialdehyde, membrane stability index, relative leaf water content, photosynthetic leaf gas exchange, chlorophyll fluorescence efficiency of photosystem-II, and photosynthetic pigments are observed in plants during unfavorable environmental conditions. Plant rhizobacteria are one of the more crucial chemical messengers that mediate plant development in response to stressed conditions. The interaction of plant rhizobacteria with essential plant nutrition can enhance the agricultural sustainability of various plant genotypes or cultivars. Rhizobacterial inoculated plants induce biochemical variations resulting in increased stress resistance efficiency, defined as induced systemic resistance. Omic strategies revealed plant rhizobacteria inoculation caused the upregulation of stress-responsive genes—numerous recent approaches have been developed to protect plants from unfavorable environmental threats. The plant microbes and compounds they secrete constitute valuable biostimulants and play significant roles in regulating plant stress mechanisms. The present review summarized the recent developments in the functional characteristics and action mechanisms of plant rhizobacteria in sustaining the development and production of plants under unfavorable environmental conditions, with special attention on plant rhizobacteria-mediated physiological and molecular responses associated with stress-induced responses.
Phylogenetic position and plastid genome structure of Vietorchis, a mycoheterotrophic genus of Orchidaceae (subtribe Orchidinae) endemic to Vietnam
Authors: Samigullin Tahir H. , Logacheva Maria D. , Averyanov Leonid V. , Zeng Si-Jin , Fu Long-Fei , Nuraliev Maxim S.
Published: May 2024

The orchid genus Vietorchis comprises three species, all discovered in the 21 century. Each of these species is achlorophyllous, mycoheterotrophic and is known to be endemic to Vietnam. The type species of the genus, V. aurea, occurs in a single location in northern Vietnam within a lowland limestone karstic area. Vietorchis furcata and V. proboscidea, in contrast, are confined to mountains of southern Vietnam, far away from any limestone formations. Taxonomic placement of Vietorchis remained uncertain for the reason of inconclusive morphological affinities. At the same time, the genus has never been included into molecular phylogenetic studies. We investigate the phylogenetic relationships of two species of Vietorchis (V. aurea and V. furcata) based on three DNA datasets: (1) a dataset comprising two nuclear regions, (2) a dataset comprising two plastid regions, and (3) a dataset employing data on the entire plastid genomes. Our phylogenetic reconstructions support the placement of Vietorchis into the subtribe Orchidinae (tribe Orchideae, subfamily Orchidoideae). This leads to a conclusion that the previously highlighted similarities in the rhizome morphology between Vietorchis and certain mycoheterotrophic genera of the subfamilies Epidendroideae and Vanilloideae are examples of a convergence. Vietorchis is deeply nested within Orchidinae, and therefore the subtribe Vietorchidinae is to be treated as a synonym of Orchidinae. In the obtained phylogenetic reconstructions, Vietorchis is sister to the photosynthetic genus Sirindhornia. Sirindhornia is restricted to limestone mountains, which allows to speculate that association with limestone karst is plesiomorphic for Vietorchis. Flower morphology is concordant with the molecular data in placing Vietorchis into Orchidinae and strongly supports the assignment of the genus to one of the two major clades within this subtribe. Within this clade, however, Vietorchis shows no close structural similarity with any of its genera; in particular, the proximity between Vietorchis and Sirindhornia has never been proposed. Finally, we assembled the plastid genome of V. furcata, which is 65969 bp long and contains 45 unique genes, being one of the most reduced plastomes in the subfamily Orchidoideae. The plastome of Vietorchis lacks any rearrangements in comparison with the closest studied autotrophic species, and possesses substantially contracted inverted repeats. No signs of positive selection acting on the protein-coding plastid sequences were detected.
Spatial variations impact the soil fungal communities of Larix gmelinii forests in Northeast China
Authors: Zhao Wen , Huang Kaichuan , Mumin Reyila , Li Junning , Sun Yifei , Cui Baokai
Published: May 2024

Soil fungi play a critical role in the biogeochemical cycles of forest ecosystems. Larix gmelinii is a strong and important timber tree species, which forms close associations with a wide range of soil fungi. However, the temporal-spatial disparity effects on the assembly of soil fungal communities in L. gmelinii forests are poorly understood. To address these questions, a total of 120 samples, including 60 bulk soil and 60 root samples, were collected from Aershan and Genhe in July (summer) and October (autumn)2021. We obtained 7,788 operational taxonomic units (OTUs) after merging, filtering, and rarefying using high-throughput sequencing. The dominant phyla are Basidiomycota, Ascomycota, Mortierellomycota, and Mucoromycota. There were 13 dominant families, among which the families with average relative abundance more than 5% included Thelephoraceae, Mortierellaceae, Archaeorhizomycoaceae, and Inocybaceae. In the functional guilds, symbiotrophic fungi had a relative advantage in the identified functions, and the relative abundances of pathotrophic and saprotrophic fungi varied significantly between sites. There were 12 families differentially expressed across compartments, 10 families differentially expressed between seasons, and 69 families were differentially expressed between sites. The variation in alpha diversity in the bulk soil was greater than that in the rhizosphere soil. Among the three parts (compartment, season, and site), the site had a crucial effect on the beta diversity of the fungal community. Deterministic processes dominated fungal community assembly in Genhe, whereas stochastic processes dominated in Aershan. Soil physicochemical properties and climatic factors significantly affected fungal community structure, among which soil total nitrogen and pH had the greatest effect. This study highlights that spatial variations play a vital role in the structure and assembly of soil fungal communities in L. gmelinii forests, which is of great significance for us in maintaining the health of the forests.
Direct and indirect effects of psychological well-being and therapeutic alliance on therapy outcome in eating disorders
Authors: Muzi Laura , Carone Nicola , Mirabella Marta , Franco Anna , Rugo Michele A. , Mazzeschi Claudia , Lingiardi Vittorio
Published: May 2024

Introduction

Outcome research in eating disorders (EDs) is commonly focused on psychopathological dysfunction. However, Ryff’s model of psychological well-being (PWB) has shown promising—yet preliminary—results with ED patients. Additionally, despite substantial evidence highlighting the association between the therapeutic alliance and treatment outcome, findings in ED samples remain unclear. The present study aimed at exploring the direct effect of PWB dimensions and the early therapeutic alliance on ED patients’ individual treatment responses, as well as the mediating role played by the early therapeutic alliance in the relationship between PWB dimensions and overall pre-post symptom change.

Methods

A sample of N = 165 ED patients assigned female at birth, who were receiving treatment in a residential program, completed the Psychological Well-Being Scale at treatment intake and the Working Alliance Inventory after the first four psychotherapy sessions. Patients also completed the Outcome Questionnaire-45.2 at the same time point and during the week prior to discharge.

Results

The PWB dimensions of autonomy, positive relations, and self-acceptance were associated with clinically significant change, while the dimensions of personal growth and self-acceptance were associated with reliable change. The early therapeutic alliance showed both direct and indirect effects on therapy outcome, predicting clinically significant and reliable symptom reduction. It also emerged as a significant mediator in the relationship between all PWB dimensions and overall symptomatic change.

Conclusion

The identification of individual, adaptive characteristics in ED patients that might influence their development of an early therapeutic alliance may help therapists to predict relationship ruptures and tailor their interventions to enhance treatment effectiveness.
Predictive model of suicide risk in Colombian university students: quantitative analysis of associated factors
Authors: Cañón Buitrago Sandra Constanza , Pérez Agudelo Juan Manuel , Narváez Marín Mariela , Montoya Hurtado Olga Lucia , Bermúdez Jaimes Gloria Isabel
Published: May 2024

Introduction

The risk of suicide and completed suicides among young university students presents critical challenges to mental and public health in Colombia and worldwide. Employing a quantifiable approach to comprehend the factors associated with these challenges can aid in visualizing the path towards anticipating and controlling this phenomenon.

Objective

Develop a predictive model for suicidal behavior in university students, utilizing predictive analytics.

Method

We conducted an observational, retrospective, cross-sectional, and analytical research study at the University of Manizales, with a focus on predictive applicability. Data from 2,436 undergraduate students were obtained from the research initiative “Building the Future: World Mental Health Surveys International College Students.”

Results

The top ten predictor variables that generated the highest scores (ranking coefficients) for the sum of factors were as follows: history of sexual abuse (13.21), family history of suicide (11.68), medication (8.39), type of student (7.4), origin other than Manizales (5.86), exposure to cannabis (4.27), exposure to alcohol (4.42), history of physical abuse (3.53), religiosity (2.9), and having someone in the family who makes you feel important (3.09).

Discussion

Suicide involves complex factors within psychiatric, medical, and societal contexts. Integrated detection and intervention systems involving individuals, families, and governments are crucial for addressing these factors. Universities also play a role in promoting coping strategies and raising awareness of risks. The predictive accuracy of over 80% in identifying suicide risk underscores its significance.

Conclusion

The risk factors related to suicidal behavior align with the findings in specialized literature and research in the field. Identifying variables with higher predictive value enables us to take appropriate actions for detecting cases and designing and implementing prevention strategies.
Protocol for the Support Application for Food PAntrieS trial: design, implementation, and evaluation plan for a digital application to promote healthy food access and support food pantry operations
Authors: Barnett Daniel J. , Sundermeir Samantha M. , Reznar Melissa M. , Lightner Alexis , Poirier Lisa , Rosenblum Andrew J. , Oladimeji Ayoyemi Toheeb , Igusa Takeru , Neff Roni , Ruggiero Cara F. , Lewis Emma C. , Jager Leah , Moses Leena , Velez-Burgess Veronica , Gagnon Brooke , Attar Noor , Gittelsohn Joel
Published: May 2024

Introduction

Food-insecure households commonly rely on food pantries to supplement their nutritional needs, a challenge that was underscored during the COVID-19 pandemic. Food pantries, and the food banks that supply them, face common challenges in meeting variable client volume and dietary needs under normal and emergency (e.g., pandemic, natural disaster) conditions. A scalable digital strategy that has the capacity to streamline the emergency food distribution system, while promoting healthy food options, managing volunteer recruitment and training, and connecting to emergency management systems in times of need, is urgently required. To address this gap, we are developing a working mobile application (app) called the Support Application for Food PAntrieS (SAFPAS) and will evaluate its feasibility and impact on food pantry staff preparedness, stocking, and client uptake of healthful foods and beverages in two urban United States settings.

Methods

This paper describes the protocol for a randomized controlled trial of the SAFPAS mobile application. We will conduct formative research in Baltimore, Maryland and Detroit, Michigan to develop and refine the SAFPAS app and increase scalability potential to other urban settings. Then we will test the app in 20 food pantries in Baltimore randomized to intervention or comparison. The impact of the app will be evaluated at several levels of the emergency food system, including food pantry clients (n = 360), food pantry staff and volunteers (n = 100), food pantry stock, and city agencies such as the local food bank and Office of Emergency Management. The primary outcome of the SAFPAS trial is to improve the healthfulness of the foods received by food pantry clients, measured using the Food Assessment Scoring Tool (FAST). Post-trial, we will conduct additional formative research in Detroit to prepare the app for scale-up.

Discussion

We anticipate that SAFPAS will improve alignment in the supply and demand for healthy foods among food pantry clients, food pantries, and city agencies which supply food in Baltimore. Real-time, bidirectional communication between entities across the system allows for increased situational awareness at all levels during normal and emergency operations. By conducting formative research in Detroit, we hope to increase the scalability of the SAFPAS app to additional settings nationwide.

Clinical trial registration

NCT87654321. https://classic.clinicaltrials.gov/ct2/show/NCT05880004.
Comparing the effectiveness of narrative therapy and EMDR-GTEP protocols in the treatment of post-traumatic stress in children exposed to humanitarian crises
Authors: Dozio Elisabetta , Bizouerne Cécile , Wamba Valdes , Atienza Ninon
Published: May 2024

Background

The mental health of children living in humanitarian crisis situations is a major issue. Post-traumatic stress disorder (PTSD) causes great psychological suffering and has negative consequences on children's development. The aim of the study was to analyze retrospective data collected in a mental health and psychosocial support program for children in the Central African Republic, and to compare results of two trauma-focused treatment interventions: the narrative protocol Action contre la Faim (ACF)/KONO; and the EMDR-based Group Trauma Episode Protocol (G-TEP). Both protocols are proposed in a group setting and led by paraprofessionals.

Methods

In the program, 884 children attended a psychoeducation session and after that, 661 children (290 for ACF/KONO and 371 for G-TEP) benefited from all treatment sessions. PTSD was measured by the Children's Revised Impact of Event Scale (CRIES-8). General distress was measured by the Child Psychosocial Distress Screener (CPDS). Data were collected before and after treatment, and measured 5 months after the end of treatment for 185 children.

Results

Participants in the ACF/KONO group show a significant reduction on CRIES-8 (t = 44.8; p < 0.001, effect size = 2.63) and CPDS (t = 38.2; p < 0.001, effect size = 2.24). Participants to the G-TEP protocol show a significant effect with reduced scores on the CRIES-8 (t = 49.2; p < 0.001, effect size = 2.55) and CPDS (t = 57.2; p < 0.001, effect size = 2.97). A Student's t-test comparing the ACF/KONO and G-TEP groups shows no significant difference between the two types of treatment between pre- and post-treatment CRIES-8 scores (t = 1.744; p = 0.514, effect size = 0.040) and CPDS scores (t = 1.688; p = 0.092, effect size = 0.323). An analysis of the follow-up data for the 185 children shows that the effects of both protocols are maintained over time with mean scores after treatment and follow-up below the clinical cut-off for both CPDS (<8) and CRIES-8 (<17).

Conclusions

Both protocols have been shown to be effective in reducing traumatic symptoms in children exposed to conflict; they can be conducted by paraprofessionals and used in humanitarian crisis situations.
Comparing locomotor intensity indicators in soccer training and competition across contextual factors: a study of replaced coaches in a Portuguese professional 1st league team
Authors: Sousa Honorato , Clemente Filipe Manuel , Sarmento Hugo , Gouveia Élvio R. , Musa Rabiu Muazu
Published: May 2024

This study aims to examine, for each head coach (HC) replaced, the association between training intensity and physical performances obtained in games. Furthermore, the study investigated how contextual factors influence locomotor and mechanical performance association. External load variables were collected using Global Positioning System (GPS) devices across the 4 weeks and 4 games before and after the replacement in a professional adult male soccer team. Six different HC records were analysed (48.8 ± 7.4 years of age; 11.2 ± 3.9 years as an HC) during a three-season span (2020/21–2022/2023). There were marked differences within player variability across the two coaching regimes. Game loads didn't reflect training-related performance, with differences ranging from −71.4% to −9.9%. Players under the outgoing coaches have greater coverage of meters per minute. Meters per minute, distance covered over 18 km/h and high-speed running (all in training) are found to be significant variables influenced by contextual factors. Within-subject and time, training loads did not reflect game-related loads/performances, with starters showing higher deficits (ranging from −79.0 to −14.5). The study suggests that changes in soccer HC can affect players' training intensity and game performance, influenced by various contextual factors and not directly correlated. This type of information might be very suitable to improve training load periodization and programming. For further research avenues, could be the study of the variation of the psychological states of the players at the time of the dismissal and hiring of the HCs, associating them with the physiological performance at the same moments.
The influence of online information on consumers’ channel migration behavior of fresh agricultural products
Authors: Cui Ningbo , Dong Jin , Fan Xiaofan , Zhao Duanyang , Liang Mingshuo , Shi Jiaoyu
Published: May 2024

Introduction

Compliance with the latest patterns in online consumption of fresh agricultural products should prioritize the shifts in consumer behavior. This study aimed to clarify the influencing factors of consumers’ channel migration behavior of fresh agricultural products. While the migration of consumers’ consumption of fresh agricultural products to online channels is an undeniable fact, and this trend continues, literature on this topic remains limited.

Methods

Based on SOR theory, and from the dual perspectives of information transmission and information reception, this study exploratively introduced the network affinity of consumers, and constructed the concept model of the influencing factors of consumers’ channel migration behavior of fresh agricultural products including information acquisition and risk perception. 416 valid questionnaires were used to conduct structural equation model analysis.

Results

The results confirm that product information and platform information significantly affect consumers’ channel migration behavior of fresh agricultural products. Product information including feature information and price information has a positive influence on consumers’ channel migration behavior of fresh agricultural products. The same is true for such behavior and the platform information including service information and logistics information. Risk perception plays a partial mediating role in the influence of product information variables and platform information variables on consumers’ online purchasing and migration behavior of fresh agricultural products. Network affinity negatively moderates the causal relationship between product information and risk perception as well as that between platform information and risk perception. The effect is more pronounced for consumers with high network affinity than those with low network affinity.

Discussion

The study presented in this paper offers a replicable theoretical framework for future discussions on consumer channel migration behavior, and enriches the literature on consumer online consumption behavior. It is highly meaningful for further improving the online consumption stickiness, tapping the potential of online consumption and improving the circulation efficiency of fresh agricultural products in the post-pandemic era.
How e-commerce can boost China’s high-quality agricultural exports
Authors: Li Jia , Shi Jinming , Cao Ruihan , Wu Jingyi , Liu Jianxu
Published: May 2024

Introduction

Export quality improvement is a crucial path for a country or region to climb up the advanced division of labor in the global value chain. For developing countries that have long been at the lower end of the global value chain division of labor, the dominance of agricultural trade is often controlled by international retailers, leading to higher costs of agricultural trade and hindering the upgrading of the quality of agricultural exports. As a traditional agricultural exporting country, China still needs a competitive advantage despite the large scale of its agricultural exports. Currently, e-commerce can provide buyers and sellers with comprehensive transaction information and technical support, allowing them to realize rational allocation of resources and export upgrading. Therefore, studying how e-commerce can promote the quality upgrade of agricultural exports is crucial for China to build a trade power.

Methods

This paper clarifies the mechanism of e-commerce’s theoretical impact on the quality of agricultural exports and then empirically tests it using a high-dimensional fixed-effects model with Chinese customs data from 2000 to 2020 as a sample.

Results

The results show that e-commerce significantly promotes the quality of agricultural exports in all regions of China, and this conclusion still holds after various robustness tests; the heterogeneity test shows that e-commerce fosters the quality of agricultural exports in eastern China, densely populated regions, and economically underdeveloped regions, especially in the case of heterogeneous products; the mechanism analysis confirms that e-commerce promotes the quality of agricultural exports mainly through the optimization of the agricultural industry chain and supply chain, and the enhancement of the level of servicing. Mechanism analysis confirms that e-commerce improves agricultural export quality mainly through optimizing the agricultural industry chain and supply chain, improving the level of servitization, and docking the demand information of the consumer market, etc. Expanded analysis shows that constructing cross-border e-commerce platforms also significantly improves the quality of micro enterprises’ agricultural exports. This paper enriches the research on e-commerce and agricultural trade.

Discussion

This paper provides an essential reference for constructing a robust agricultural trade country and developing high-quality agriculture. Despite encompassing data up to 2020, in the context of today’s global economic volatility directly affecting agricultural trade, future investigations will broaden the scope to delve deeper into how e-commerce can help countries cope with global economic uncertainty.
A new concept in assessing adaptability index for superior potential cropping intensity in early-maturing rice
Authors: Anshori Muhammad Fuad , Musa Yunus , Farid Muh , Jayadi Muh , Bahrun Abd Haris , Yassi Amir , Sulaiman Andi Amran , Huang Yi Cheng , Casimero Madonna , Llorca Lizzida , Suwarno Willy Bayuardi , Putra Muh Mukhtadir , Sembiring Hasil , Purwoko Bambang Sapta , Wasonga Daniel O. , Seleiman Mahmoud F.
Published: May 2024

Implementing a cropping intensity program with rice cultivation four times a year (CI 400) can be achieved using early maturing varieties of rice. However, this development needs to pay attention to the adaptability of the varieties planted to ensure successful implementation. The adaptability approach is a combination of assessing stability and productivity potential. This concept has been developed and applied in several studies, including research on rice. However, this approach is considered less comprehensive because it is non-parametric and only focuses on one stability analysis. Therefore, a systematic integration of various stability analyses, including index methods, is needed to comprehensively assess adaptability, particularly for early-maturing rice in South Sulawesi. This region is characterized by a dynamic climate zone and is one of the top four highest rice producers in Indonesia. Meanwhile, this study aims to develop a comprehensive adaptability index and select the best early-maturing rice varieties, especially in South Sulawesi. The investigation was conducted in Bone, Soppeng, and Gowa over two seasons using a nested randomized complete block design, with organized replications in each environment (location-season). Additionally, there was a significant focus on the application of five early-maturing and two check rice varieties, with each factor repeated three times at each location, totaling 126 experimental units. The results showed that the adaptability index, by combining stability rank accumulation with yield min max standardization, was effective at assessing the yield potential and stability of early-maturing rice varieties in supporting CI 400. Inpari 13 had the best index value at 0.55, followed by Cakrabuana at 0.31; hence both were recommended as adaptive early-maturing rice varieties, especially in South Sulawesi.
Solar Sail Optimal Performance in Heliocentric Nodal Flyby Missions
Authors: Mengali Giovanni , Bassetto Marco , Quarta Alessandro A.
Published: May 2024

Solar sails are propellantless propulsion systems that extract momentum from solar radiation pressure. They consist of a large ultrathin membrane, typically aluminized, that reflects incident photons from the Sun to generate thrust for space navigation. The purpose of this study is to investigate the optimal performance of a solar sail-based spacecraft in performing two-dimensional heliocentric transfers to inertial points on the ecliptic that lie within an assigned annular region centered in the Sun. Similar to ESA’s Comet Interceptor mission, this type of transfer concept could prove useful for intercepting a potential celestial body, such as a long-period comet, that is passing close to Earth’s orbit. Specifically, it is assumed that the solar sail transfer occurs entirely in the ecliptic plane and, in analogy with recent studies, the flyby points explored are between 0.85au and 1.35au from the Sun. The heliocentric dynamics of the solar sail is described using the classical two-body model, assuming the spacecraft starts from Earth orbit (assumed circular), and an ideal force model to express the sail thrust vector. Finally, no constraint is imposed on the arrival velocity at flyby. Numerical simulation results show that solar sails are an attractive option to realize these specific heliocentric transfers.
APEIOU Integration for Enhanced YOLOV7: Achieving Efficient Plant Disease Detection
Authors: Zhao Yun , Lin Chengqiang , Wu Na , Xu Xing
Published: May 2024

Plant diseases can severely hamper plant growth and yield. Currently, these diseases often manifest diverse symptoms, characterized by small targets and high quantities. However, existing algorithms inadequately address these challenges. Therefore, this paper proposes improving plant disease detection by enhancing a YOLOV7-based model. Initially, we strengthen multi-scale feature fusion using the fourth prediction layer. Subsequently, we reduce model parameters and the computational load with the DW-ELAN structure, followed by optimizing the downsampling process using the improved SPD-MP module. Additionally, we enhance the Soft-SimAM attention mechanism to prioritize crucial feature components and suppress irrelevant information. To distinguish overlapping predicted and actual bounding box centroids, we propose the APEIOU loss function and refine the offset formula and grid matching strategy, significantly increasing positive samples. We train the improved model using transfer learning. The experimental results show significant enhancements: the mAP, F1 score, Recall, and Precision are 96.75%, 0.94, 89.69%, and 97.64%, respectively. Compared to the original YOLOV7, the improvements are 5.79%, 7.00%, 9.43%, and 3.30%. The enhanced model outperforms the original, enabling the more precise detection of plant diseases.