bluuebunny/crossref_metadata_2025 huggingface dataset:
Epigenetics and Inflammation in Diabetic Nephropathy
Authors: Shao Bao-Yi , Zhang Shao-Fei , Li Hai-Di , Meng Xiao-Ming , Chen Hai-Yong
Published: May 2021

Diabetic nephropathy (DN) leads to high morbidity and disability. Inflammation plays a critical role in the pathogenesis of DN, which involves renal cells and immune cells, the microenvironment, as well as extrinsic factors, such as hyperglycemia, chemokines, cytokines, and growth factors. Epigenetic modifications usually regulate gene expression via DNA methylation, histone modification, and non-coding RNAs without altering the DNA sequence. During the past years, numerous studies have been published to reveal the mechanisms of epigenetic modifications that regulate inflammation in DN. This review aimed to summarize the latest evidence on the interplay of epigenetics and inflammation in DN, and highlight the potential targets for treatment and diagnosis of DN.
The Effectiveness of Post-exercise Stretching in Short-Term and Delayed Recovery of Strength, Range of Motion and Delayed Onset Muscle Soreness: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Afonso José , Clemente Filipe Manuel , Nakamura Fábio Yuzo , Morouço Pedro , Sarmento Hugo , Inman Richard A. , Ramirez-Campillo Rodrigo
Published: May 2021

Background: Post-exercise (i.e., cool-down) stretching is commonly prescribed for improving recovery of strength and range of motion (ROM) and diminishing delayed onset muscular soreness (DOMS) after physical exertion. However, the question remains if post-exercise stretching is better for recovery than other post-exercise modalities.

Objective: To provide a systematic review and meta-analysis of supervised randomized-controlled trials (RCTs) on the effects of post-exercise stretching on short-term (≤1 h after exercise) and delayed (e.g., ≥24 h) recovery makers (i.e., DOMS, strength, ROM) in comparison with passive recovery or alternative recovery methods (e.g., low-intensity cycling).

Methods: This systematic review followed PRISMA guidelines (PROSPERO CRD42020222091). RCTs published in any language or date were eligible, according to P.I.C.O.S. criteria. Searches were performed in eight databases. Risk of bias was assessed using Cochrane RoB 2. Meta-analyses used the inverse variance random-effects model. GRADE was used to assess the methodological quality of the studies.

Results: From 17,050 records retrieved, 11 RCTs were included for qualitative analyses and 10 for meta-analysis (n = 229 participants; 17–38 years, mostly males). The exercise protocols varied between studies (e.g., cycling, strength training). Post-exercise stretching included static stretching, passive stretching, and proprioceptive neuromuscular facilitation. Passive recovery (i.e., rest) was used as comparator in eight studies, with additional recovery protocols including low intensity cycling or running, massage, and cold-water immersion. Risk of bias was high in ~70% of the studies. Between-group comparisons showed no effect of post-exercise stretching on strength recovery (ES = −0.08; 95% CI = −0.54–0.39; p = 0.750; I2 = 0.0%; Egger's test p = 0.531) when compared to passive recovery. In addition, no effect of post-exercise stretching on 24, 48, or 72-h post-exercise DOMS was noted when compared to passive recovery (ES = −0.09 to −0.24; 95% CI = −0.70–0.28; p = 0.187–629; I2 = 0.0%; Egger's test p = 0.165–0.880).

Conclusion: There wasn't sufficient statistical evidence to reject the null hypothesis that stretching and passive recovery have equivalent influence on recovery. Data is scarce, heterogeneous, and confidence in cumulative evidence is very low. Future research should address the limitations highlighted in our review, to allow for more informed recommendations. For now, evidence-based recommendations on whether post-exercise stretching should be applied for the purposes of recovery should be avoided, as the (insufficient) data that is available does not support related claims.

Systematic Review Registration: PROSPERO, identifier: CRD42020222091.
The Analysis of Integration of Ideological Political Education With Innovation Entrepreneurship Education for College Students
Authors: Zhao Xinyuan , Zhang Jinle
Published: May 2021

This study aims to analyze the integrated construction and application of ideological and political education (IPE) and innovation and entrepreneurship education (IEE) in colleges based on the positive psychological quality of entrepreneurship. 549 college students are selected for a questionnaire survey. The correlations between entrepreneurial psychological quality of college students, IEE in colleges, IPE, and entrepreneurial self-efficacy are analyzed with the Spearman correlation and linear regression. The hierarchical regression analysis is used to analyze the intermediary role of entrepreneurial self-efficacy in IEE, IPE in colleges, and entrepreneurial psychological quality of college students. The results show that the entrepreneurial psychological quality of college students is significantly different in gender, family location, and grade level (p < 0.05); the main channels of IPE and daily IPE have significant positive effects on the positive entrepreneurship psychological quality (p < 0.05), and have extremely significant positive effects on the entrepreneurial self-efficacy (p < 0.001); innovation and entrepreneurship course, innovation and entrepreneurship practices, innovation and entrepreneurship environment, and total score of IEE have significant positive correlations with positive entrepreneurship psychological quality and entrepreneurial self-efficacy of college students (p < 0.05); and the intermediary effect of entrepreneurial self-efficacy accounts for 33.49% on the IPE and entrepreneurial psychological quality, and 41.85% on IEE and entrepreneurial psychological quality. In short, IPE and IEE can effectively improve the positive psychological quality and self-efficacy of college students, and the joint construction of the two can have a more significant effect.
COVID-19 Pandemic and Physical Exercise: Lessons Learnt for Confined Communities
Authors: Ghram Amine , Bragazzi Nicola Luigi , Briki Walid , Jenab Yaser , Khaled Mehdi , Haddad Monoem , Chamari Karim
Published: May 2021

The novel pandemic called “Coronavirus Disease 2019” (COVID-19), as a global public health emergency and global threat, has affected many countries in unpredictable ways and impacted on physical activity (PA) behaviors to various extents. Specific populations including refugees, asylum seekers, and prisoners, are vulnerable groups with multiple complex health needs and worse health outcomes with respect to the general population worldwide and at high risk of death from the “Severe Acute Respiratory Syndrome-related Coronavirus type 2” (SARS-CoV-2). Governments around the world have been implementing preventive healthcare policies, including physical and social distancing, isolation, and confinement, to mitigate against the burden imposed by the COVID-19 outbreak. This pandemic period is characterized by reduced or lack of movement. During this period of lockdown, PA can represent an immunotherapy and a preventative approach to avoid the harmful effects of inactivity due to the pandemic. Moreover, PA could be prescribed to improve the immune system of specific populations (refugees, asylum seekers, and prisoners), which particularly experience the condition of being confined. The present narrative review discusses the potential impacts of COVID-19 pandemic on these specific populations’ health status and the importance of performing PA/exercise to reduce the deleterious effects of COVID-19 pandemic. In addition, we aim to provide useful recommendations on PA/exercise for these specific populations to maintain their level of independence, physical, and mental health as well as their wellbeing.
Abusive Supervision, Leader-Member Exchange, and Creativity: A Multilevel Examination
Authors: He Changqing , Teng Rongrong , Zhou Liying , Wang Valerie Lynette , Yuan Jing
Published: May 2021

Despite the growing attention on the topic of abusive supervision, how abusive supervision affects individual and team creativity have not yet been thoroughly investigated. Drawn from the perspective of leader-member exchange (LMX), the current study develops a multilevel model to describe the relationships between abusive supervision and creativity at both team and individual levels, with a focus on the roles played by team-level leader-member exchange (TLMX) and LMX differentiation (DLMX). Based on data collected from 319 team members and their team leaders in 71 teams, the results show that abusive supervision has a negative relationship with TLMX, a practice that is conducive to both team and individual creativity. At the team level, the negative relationship between abusive supervision and TLMX is lessened by a higher level of DLMX. In addition, the positive relationship between TLMX and team creativity is weakened by a higher level of DLMX. Theoretical and practical implications of the findings are discussed.
More Positive Emotions During the COVID-19 Pandemic Are Associated With Better Resilience, Especially for Those Experiencing More Negative Emotions
Authors: Israelashvili Jacob
Published: May 2021

The ongoing COVID-19 pandemic has taken a significant toll on mental health; people around the world are experiencing high levels of stress and deteriorated wellbeing. The past research shows that positive emotions can help people cultivate a resilient mindset; however, the reality created by the global crisis itself limits the opportunities for experiencing positive emotions. Thus, it is unclear to what extent their effect is strong enough to counter the psychological impact of the current pandemic. Here, the author reports the findings of a survey conducted across two large representative samples in the United Kingdom and the United States (Ntotal = 2000) during the first wave of the COVID-19 pandemic (in Spring 2020). A linear regression model revealed that the presence of positive emotions is strongly linked with resilience, in particular for individuals experiencing more negative emotions. These results show that positive emotions are particularly important to mental health in the context of high stress, reflected by increased levels of negative emotional experiences. These results are also consistent with the existential positive psychology perspective, which posits that even negative emotions can contribute to wellbeing once they are transformed. The author discusses the potential of positive emotions to transform suffering and thereby ameliorate the negative impact of the present collective crisis.
Co-occurrence Pattern of Posttraumatic Stress Disorder and Depression in People Living With HIV: A Latent Profile Analysis
Authors: Meng Jingjing , Tang Chulei , Xiao Xueling , Välimäki Maritta , Wang Honghong
Published: May 2021

Background: The comorbidity of posttraumatic stress disorder (PTSD) and depression is common among people living with the HIV (PLWH). Given the high prevalence and serious clinical consequences of the comorbidity of these two disorders, we conducted a latent profile analysis to examine the co-occurrence pattern of PTSD and depression in PLWH.

Methods: The data for this cross-sectional study of PLWH were collected from 602 patients with HIV in China. A secondary analysis using latent profile analysis was conducted to examine HIV-related PTSD and depression symptoms.

Results: A four-class solution fits the data best, with the four classes characterized as asymptomatic (42.9%), mild symptoms (33.9%), low to moderate symptoms (19.8%), and high to moderate symptoms (3.4%). The severity of PTSD and depression symptoms was comparable in this solution, and no group was dominated by PTSD or depression.

Conclusion: The absence of a distinct subcluster of PLWH with only PTSD or depression symptoms supports that PTSD and depression in PLWH are psychopathological manifestations after traumatic exposures. Health care staff should pay more attention to the existence of comorbid symptoms of individuals, develop integrated interventions for the symptoms cluster, and evaluate their effectiveness in clinical practice.
Sport and the LGBTIQ+ Community: A South Australian Study
Authors: Drummond Murray , Elliott Sam , Drummond Claire , Prichard Ivanka , Lewis Lucy , Bevan Nadia
Published: May 2021

This is a paper based on research with the LGBTIQ+ community in South Australia, the likes of which has not been conducted previously in the state. The paper, which utilized both quantitative (n = 148) and qualitative (n = 31) research methods identifies the key issues that the LGBTIQ+ community face with respect to sporting involvement. There were a range of themes that emerged in relation to a variety of topics including homophobia, sexism and gender discrimination, gender roles and gender stereotypes. This paper provides data and discussion around this important part of the research, which has implications pertaining to sporting organizations and the LGBTIQ+ community.
A Case Report of Wernicke's Encephalopathy Associated With Schizophrenia
Authors: He Jingqi , Li Jinguang , Li Zhijun , Ren Honghong , Chen Xiaogang , Tang Jinsong
Published: May 2021

Introduction: Wernicke's encephalopathy (WE) is a severe neurological syndrome often associated with alcoholism. Clinicians tend to ignore WE in other non-alcoholic clinical settings related to malnutrition and thiamine deficiency, resulting in delayed diagnosis. The diagnosis becomes more difficult when WE is secondary to psychiatric illnesses as symptoms can be masked by the primary disease.

Case Presentation: We present a case of a 56-year-old female patient with schizophrenia who was admitted to the hospital for mental and behavioral disorder, without history of alcohol. She presented symptoms of ophthalmoplegia and high muscular tension, and the brain MRI showed symmetric lesions in the bilateral basal ganglia and third ventricle. She responded well to thiamine and was discharged on hospital day 22.

Conclusion: The psychiatrists should be on the alert for starvation-induced WE, especially for patients suffering from malnutrition. WE is a preventable and treatable disease, so once suspected of WE, patients ought to take adequate supplements of thiamine immediately.
Implications of Zoonoses From Hunting and Use of Wildlife in North American Arctic and Boreal Biomes: Pandemic Potential, Monitoring, and Mitigation
Authors: Keatts Lucy O. , Robards Martin , Olson Sarah H. , Hueffer Karsten , Insley Stephen J. , Joly Damien O. , Kutz Susan , Lee David S. , Chetkiewicz Cheryl-Lesley B. , Lair Stéphane , Preston Nicholas D. , Pruvot Mathieu , Ray Justina C. , Reid Donald , Sleeman Jonathan M. , Stimmelmayr Raphaela , Stephen Craig , Walzer Chris
Published: May 2021

The COVID-19 pandemic has re-focused attention on mechanisms that lead to zoonotic disease spillover and spread. Commercial wildlife trade, and associated markets, are recognized mechanisms for zoonotic disease emergence, resulting in a growing global conversation around reducing human disease risks from spillover associated with hunting, trade, and consumption of wild animals. These discussions are especially relevant to people who rely on harvesting wildlife to meet nutritional, and cultural needs, including those in Arctic and boreal regions. Global policies around wildlife use and trade can impact food sovereignty and security, especially of Indigenous Peoples. We reviewed known zoonotic pathogens and current risks of transmission from wildlife (including fish) to humans in North American Arctic and boreal biomes, and evaluated the epidemic and pandemic potential of these zoonoses. We discuss future concerns, and consider monitoring and mitigation measures in these changing socio-ecological systems. While multiple zoonotic pathogens circulate in these systems, risks to humans are mostly limited to individual illness or local community outbreaks. These regions are relatively remote, subject to very cold temperatures, have relatively low wildlife, domestic animal, and pathogen diversity, and in many cases low density, including of humans. Hence, favorable conditions for emergence of novel diseases or major amplification of a spillover event are currently not present. The greatest risk to northern communities from pathogens of pandemic potential is via introduction with humans visiting from other areas. However, Arctic and boreal ecosystems are undergoing rapid changes through climate warming, habitat encroachment, and development; all of which can change host and pathogen relationships, thereby affecting the probability of the emergence of new (and re-emergence of old) zoonoses. Indigenous leadership and engagement in disease monitoring, prevention and response, is vital from the outset, and would increase the success of such efforts, as well as ensure the protection of Indigenous rights as outlined in the United Nations Declaration on the Rights of Indigenous Peoples. Partnering with northern communities and including Indigenous Knowledge Systems would improve the timeliness, and likelihood, of detecting emerging zoonotic risks, and contextualize risk assessments to the unique human-wildlife relationships present in northern biomes.
Prevalence of Depression, Anxiety, and Stress Among Repatriated Indonesian Migrant Workers During the COVID-19 Pandemic
Authors: Harjana Ngakan Putu Anom , Januraga Pande Putu , Indrayathi Putu Ayu , Gesesew Hailay Abrha , Ward Paul Russell
Published: May 2021

Introduction: Repatriated Indonesian migrant workers are vulnerable to developing serious mental health problems during the COVID-19 pandemic. This study aimed to assess the prevalence and associated factors of depression, anxiety, and stress among these populations during the COVID-19 pandemic.

Methods: Guided by the health belief model, a cross-sectional study design was employed among 335 participants, and primary data were collected through an online survey. Measured using DASS-21, anxiety, depression, and stress were the dependent variables. We performed descriptive and inferential statistical analyses—logistic regression was used to predict independently associated variables. STATA was used to execute all data analyses.

Results: The prevalence of depression, anxiety, and stress among repatriated Indonesian migrant workers were 10.15, 9.25, and 2.39%, respectively. The risk of anxiety and depression was low among those aged 21–30 years old, who had completed a university degree, were married, and had quarantined for 14 days. Conversely, the risk of anxiety and depression was high among those who had bad perceived health status, high perceived susceptibility, and negative stigma perception.

Conclusion: The prevalence of depression, anxiety, and stress among repatriated Indonesian migrant workers was relatively low compared to the general population. The risk of anxiety and depression was low among young people, educated people, and those under effective quarantine, but the risk was high among those who had negative perceptions about their health, stigma, and susceptibility to the disease.
Digital Data Sources and Their Impact on People's Health: A Systematic Review of Systematic Reviews
Authors: Li Lan , Novillo-Ortiz David , Azzopardi-Muscat Natasha , Kostkova Patty
Published: May 2021

Background: Digital data sources have become ubiquitous in modern culture in the era of digital technology but often tend to be under-researched because of restricted access to data sources due to fragmentation, privacy issues, or industry ownership, and the methodological complexity of demonstrating their measurable impact on human health. Even though new big data sources have shown unprecedented potential for disease diagnosis and outbreak detection, we need to investigate results in the existing literature to gain a comprehensive understanding of their impact on and benefits to human health.

Objective: A systematic review of systematic reviews on identifying digital data sources and their impact area on people's health, including challenges, opportunities, and good practices.

Methods: A multidatabase search was performed. Peer-reviewed papers published between January 2010 and November 2020 relevant to digital data sources on health were extracted, assessed, and reviewed.

Results: The 64 reviews are covered by three domains, that is, universal health coverage (UHC), public health emergencies, and healthier populations, defined in WHO's General Programme of Work, 2019–2023, and the European Programme of Work, 2020–2025. In all three categories, social media platforms are the most popular digital data source, accounting for 47% (N = 8), 84% (N = 11), and 76% (N = 26) of studies, respectively. The second most utilized data source are electronic health records (EHRs) (N = 13), followed by websites (N = 7) and mass media (N = 5). In all three categories, the most studied impact of digital data sources is on prevention, management, and intervention of diseases (N = 40), and as a tool, there are also many studies (N = 10) on early warning systems for infectious diseases. However, they could also pose health hazards (N = 13), for instance, by exacerbating mental health issues and promoting smoking and drinking behavior among young people.

Conclusions: The digital data sources presented are essential for collecting and mining information about human health. The key impact of social media, electronic health records, and websites is in the area of infectious diseases and early warning systems, and in the area of personal health, that is, on mental health and smoking and drinking prevention. However, further research is required to address privacy, trust, transparency, and interoperability to leverage the potential of data held in multiple datastores and systems. This study also identified the apparent gap in systematic reviews investigating the novel big data streams, Internet of Things (IoT) data streams, and sensor, mobile, and GPS data researched using artificial intelligence, complex network, and other computer science methods, as in this domain systematic reviews are not common.
Systemic Fairness for Sharing Health Data: Perspectives From Swiss Stakeholders
Authors: Geneviève Lester Darryl , Martani Andrea , Perneger Thomas , Wangmo Tenzin , Elger Bernice Simone
Published: May 2021

Introduction:Health research is gradually embracing a more collectivist approach, fueled by a new movement of open science, data sharing and collaborative partnerships. However, the existence of systemic contradictions hinders the sharing of health data and such collectivist endeavor. Therefore, this qualitative study explores these systemic barriers to a fair sharing of health data from the perspectives of Swiss stakeholders.

Methods:Purposive and snowball sampling were used to recruit 48 experts active in the Swiss healthcare domain, from the research/policy-making field and those having a high position in a health data enterprise (e.g., health register, hospital IT data infrastructure or a national health data initiative). Semi-structured interviews were then conducted, audio-recorded, verbatim transcribed with identifying information removed to guarantee the anonymity of participants. A theoretical thematic analysis was then carried out to identify themes and subthemes related to the topic of systemic fairness for sharing health data.

Results:Two themes related to the topic of systemic fairness for sharing health data were identified, namely (i) the hypercompetitive environment and (ii) the legal uncertainty blocking data sharing. The theme, hypercompetitive environment was further divided into two subthemes, (i) systemic contradictions to fair data sharing and the (ii) need of fair systemic attribution mechanisms.

Discussion:From the perspectives of Swiss stakeholders, hypercompetition in the Swiss academic system is hindering the sharing of health data for secondary research purposes, with the downside effect of influencing researchers to embrace individualism for career opportunities, thereby opposing the data sharing movement. In addition, there was a perceived sense of legal uncertainty from legislations governing the sharing of health data, which adds unreasonable burdens on individual researchers, who are often unequipped to deal with such facets of their data sharing activities.
Baidu Index and COVID-19 Epidemic Forecast: Evidence From China
Authors: Fang Jianchun , Zhang Xinyi , Tong Yang , Xia Yuxin , Liu Hui , Wu Keke
Published: May 2021

With the global spread of the Coronavirus epidemic, search engine data can be a practical tool for decision-makers to understand the epidemic's trends. This article uses trend analysis data from the Baidu search engine, the most widely used in China, to analyze the public's attention to the epidemic and the demand for N95 masks and other anti-epidemic materials and information. This kind of analysis has become an important part of information epidemiology. We have analyzed the use of the keywords “Coronavirus epidemic,” “N95 mask,” and “Wuhan epidemic” to judge whether the introduction of real-time search data has improved the efficiency of the Coronavirus epidemic prediction model. In general, the introduction of the Baidu index, whether in-sample or out-of-sample, significantly improves the prediction efficiency of the model.
Neurorehabilitation From a Distance: Can Intelligent Technology Support Decentralized Access to Quality Therapy?
Authors: Lambercy Olivier , Lehner Rea , Chua Karen , Wee Seng Kwee , Rajeswaran Deshan Kumar , Kuah Christopher Wee Keong , Ang Wei Tech , Liang Phyllis , Campolo Domenico , Hussain Asif , Aguirre-Ollinger Gabriel , Guan Cuntai , Kanzler Christoph M. , Wenderoth Nicole , Gassert Roger
Published: May 2021

Current neurorehabilitation models primarily rely on extended hospital stays and regular therapy sessions requiring close physical interactions between rehabilitation professionals and patients. The current COVID-19 pandemic has challenged this model, as strict physical distancing rules and a shift in the allocation of hospital resources resulted in many neurological patients not receiving essential therapy. Accordingly, a recent survey revealed that the majority of European healthcare professionals involved in stroke care are concerned that this lack of care will have a noticeable negative impact on functional outcomes. COVID-19 highlights an urgent need to rethink conventional neurorehabilitation and develop alternative approaches to provide high-quality therapy while minimizing hospital stays and visits. Technology-based solutions, such as, robotics bear high potential to enable such a paradigm shift. While robot-assisted therapy is already established in clinics, the future challenge is to enable physically assisted therapy and assessments in a minimally supervized and decentralized manner, ideally at the patient’s home. Key enablers are new rehabilitation devices that are portable, scalable and equipped with clinical intelligence, remote monitoring and coaching capabilities. In this perspective article, we discuss clinical and technological requirements for the development and deployment of minimally supervized, robot-assisted neurorehabilitation technologies in patient’s homes. We elaborate on key principles to ensure feasibility and acceptance, and on how artificial intelligence can be leveraged for embedding clinical knowledge for safe use and personalized therapy adaptation. Such new models are likely to impact neurorehabilitation beyond COVID-19, by providing broad access to sustained, high-quality and high-dose therapy maximizing long-term functional outcomes.
Plasma Dynamics in Low-Electron-Beta Environments
Authors: Boldyrev Stanislav , Loureiro Nuno F. , Roytershteyn Vadim
Published: May 2021

Recentin situmeasurements by the MMS and Parker Solar Probe missions bring interest to small-scale plasma dynamics (waves, turbulence, magnetic reconnection) in regions where the electron thermal energy is smaller than the magnetic one. Examples of such regions are the Earth’s magnetosheath and the vicinity of the solar corona, and they are also encountered in other astrophysical systems. In this brief review, we consider simple physical models describing plasma dynamics in such low-electron-beta regimes, discuss their conservation laws and their limits of applicability.
Male-to-Female Gender-Affirming Surgery: 20-Year Review of Technique and Surgical Results
Authors: Moisés da Silva Gabriel Veber , Lobato Maria Inês Rodrigues , Silva Dhiordan Cardoso , Schwarz Karine , Fontanari Anna Martha Vaitses , Costa Angelo Brandelli , Tavares Patric Machado , Gorgen Antonio Rebello Horta , Cabral Renan Desimon , Rosito Tiago Elias
Published: May 2021

Purpose: Gender dysphoria (GD) is an incompatibility between biological sex and personal gender identity; individuals harbor an unalterable conviction that they were born in the wrong body, which causes personal suffering. In this context, surgery is imperative to achieve a successful gender transition and plays a key role in alleviating the associated psychological discomfort. In the current study, a retrospective cohort, we report the 20-years outcomes of the gender-affirming surgery performed at a single Brazilian university center, examining demographic data, intra and postoperative complications. During this period, 214 patients underwent penile inversion vaginoplasty.

Results: Results demonstrate that the average age at the time of surgery was 32.2 years (range, 18–61 years); the average of operative time was 3.3 h (range 2–5 h); the average duration of hormone therapy before surgery was 12 years (range 1–39). The most commons minor postoperative complications were granulation tissue (20.5 percent) and introital stricture of the neovagina (15.4 percent) and the major complications included urethral meatus stenosis (20.5 percent) and hematoma/excessive bleeding (8.9 percent). A total of 36 patients (16.8 percent) underwent some form of reoperation. One hundred eighty-one (85 percent) patients in our series were able to have regular sexual intercourse, and no individual regretted having undergone GAS.

Conclusions: Findings confirm that it is a safety procedure, with a low incidence of serious complications. Otherwise, in our series, there were a high level of functionality of the neovagina, as well as subjective personal satisfaction.
InnoCube—A Wireless Satellite Platform to Demonstrate Innovative Technologies
Authors: Grzesik Benjamin , Baumann Tom , Walter Thomas , Flederer Frank , Sittner Felix , Dilger Erik , Gläsner Simon , Kirchler Jan-Luca , Tedsen Marvyn , Montenegro Sergio , Stoll Enrico
Published: May 2021

A new innovative satellite mission, the Innovative CubeSat for Education (InnoCube), is addressed. The goal of the mission is to demonstrate “the wireless satellite”, which replaces the data harness by robust, high-speed, real-time, very short-range radio communications using the SKITH (SKIpTheHarness) technology. This will make InnoCube the first wireless satellite in history. Another technology demonstration is an experimental energy-storing satellite structure that was developed in the previous Wall#E project and might replace conventional battery technology in the future. As a further payload, the hardware for the concept of a software-based solution for receiving signals from Global Navigation Satellite Systems (GNSS) will be developed to enable precise position determination of the CubeSat. Aside from technical goals this work aims to be of use in the teaching of engineering skills and practical sustainable education of students, important technical and scientific publications, and the increase of university skills. This article gives an overview of the overall design of the InnoCube.
Prediction of Food Production Using Machine Learning Algorithms of Multilayer Perceptron and ANFIS
Authors: Nosratabadi Saeed , Ardabili Sina , Lakner Zoltan , Mako Csaba , Mosavi Amir
Published: May 2021

Advancing models for accurate estimation of food production is essential for policymaking and managing national plans of action for food security. This research proposes two machine learning models for the prediction of food production. The adaptive network-based fuzzy inference system (ANFIS) and multilayer perceptron (MLP) methods are used to advance the prediction models. In the present study, two variables of livestock production and agricultural production were considered as the source of food production. Three variables were used to evaluate livestock production, namely livestock yield, live animals, and animal slaughtered, and two variables were used to assess agricultural production, namely agricultural production yields and losses. Iran was selected as the case study of the current study. Therefore, time-series data related to livestock and agricultural productions in Iran from 1961 to 2017 have been collected from the FAOSTAT database. First, 70% of this data was used to train ANFIS and MLP, and the remaining 30% of the data was used to test the models. The results disclosed that the ANFIS model with generalized bell-shaped (Gbell) built-in membership functions has the lowest error level in predicting food production. The findings of this study provide a suitable tool for policymakers who can use this model and predict the future of food production to provide a proper plan for the future of food security and food supply for the next generations.
Effects of Exogenous Trans-Zeatin and Lovastatin on Abortion of Small Seeds in ‘Dawuxing’ Loquat (Eriobotrya Japonica Lindl.)
Authors: Zhang Hui , Wang Yong-Qing , Deng Qun-Xian , Yang Zhi-Wu , Pan Cui-Ping , Chi Zhuo-Heng , Wen Lu , Yang Yun-Miao
Published: May 2021

The small seeds of loquat possess very rich and diverse genetic characteristics which can potentially serve as precious resources for plant breeding. However, they are often aborted during the seed development. Cytokinin, as an important signaling mediator, plays a pivotal regulatory role in seed development. However, the effects of exogenous cytokinin application on the development of loquat seeds are poorly understood. In this study, we analyzed the potential effects of exogenous cytokinin on the abortion of small seeds of loquat. Cytokinin (20 mg/L trans-zeatin) and cytokinin inhibitor (60 mg/L lovastatin) were sprayed on the fruits of ‘Dawuxing’ loquat during an early stage of fruit expansion. The clean water treatment was used as the control group. The results showed that exogenous trans-zeatin significantly increased the weight of small seeds, the levels of soluble sugar and starch, as well as peroxidase (POD) and superoxide dismutase (SOD) activities. It also promoted a substantial increase in the expression of POD- and SOD-related genes during the process of small seed abortion. Moreover, trans-zeatin treatment significantly increased the content of endogenous trans-zeatin in the small seeds, and this increase in content showed a trend opposite to that of control (CKA). Cytokinin dehydrogenase related genes were found to be down-regulated after trans-zeatin treatment. It was found that exogenous cytokinin inhibitor (lovastatin) treatment could induce the anti-stress reaction in the small seeds during the early stage of treatment by significantly increasing the activities of POD and SOD, and the weight of small seeds at the early stage of treatment was significantly lower than that of the control group, but reverted to the level of the control group during the late stage of the treatment. Therefore, a specific concentration of trans-zeatin treatment can promote the development of small loquat seeds, while cytokinin inhibitor (lovastatin) can significantly inhibit the development of small seeds during the early stage of treatment. In summary, this study reports for the first time that application of exogenous trans-zeatin could effectively promote the development of small loquat seeds by significantly increasing the metabolism of small seeds. The small seeds which contained rich and diverse genetic characteristics often aborted during seed development. Our study thus established a foundation for the rescue of new germplasm resources of loquat by promoting the development of small loquat seeds.
Supplementation of Microbial and Fungal Phytases to Low Protein and Energy Diets: Effects on Productive Performance, Nutrient Digestibility, and Blood Profiles of Broilers
Authors: Attia Youssef A. , Bovera Fulvia , Al-Harthi Mohammed A. , El-Din Abd El-Razek E. Tag , Said Selim Walaa
Published: May 2021

To evaluate in possible use of phytases for improving the utilization of low protein and energy diets, 420, one-day-old chicks were distributed among 7 groups (5 replicates of 12 chicks/group). During the starter (1–35 day), grower (37–56 day), and finisher (57–64 day) periods, the control group fed diets containing 21.2% crude protein (CP)-2947 Kcal/kg metabolizable energy (ME), 19.6 CP-3023 ME and 18.0 CP-3100 ME, respectively. The three low-CP groups received diets isocaloric but with −1% CP than the control, while the three low-CPME groups fed diets with −1% CP and −100 Kcal than the control. In addition, the low-CP and low-CPME groups were supplemented with 0 (low-CP_uns and low-CPME_uns), 500 U/kg of an Aspergillus niger (low-CP_AP and low-CPME_AP) or 500 FTU/kg of an Escherichia coli phytase (low-CP_EP and low-CPME_EP), respectively. Low-CP and low-CPME diets decreased (p < 0.01) the intake of feed as well as the protein and metabolizable energy conversion ratios in comparison to the control group. In general, phytases lowered (p < 0.01) the intake of feed, protein, and energy, but bacterial phytase showed a higher (p < 0.01) effect than A. niger one. The diets with low-CP and low-CPME levels decreased (p < 0.01) the amount of the excreta nitrogen. The supplementation of phytases had similar effects on digestibility of nutrients, carcass traits, bone mineralization and blood biochemistry. The supplementation of A. niger increased abdominal fat deposition of compared low-CPME diet compared to low-CPME_uns diet. All diets showed similar production index allowing the use of low-CPME diet when phytases was supplemented.
The Emergence of Arboriculture in the 1st Millennium BC along the Mediterranean’s “Far West”
Authors: Pérez-Jordà Guillem , Alonso Natàlia , Rovira Núria , Figueiral Isabel , López-Reyes Daniel , Marinval Philippe , Montes Eva , Peña-Chocarro Leonor , Pinaud-Querrac’h Rachël , Ros Jérôme , Tarongi Miguel , Tillier Margaux , Bouby Laurent
Published: May 2021

This paper presents the history of the introduction and expansion of arboriculture during the 1st millennium BC from the South of the Iberian Peninsula to the South of France. The earliest evidence of arboriculture at the beginning of the 1st millennium hails from the south of the Iberia from where it spread northward along the peninsula’s eastern edge. The different fruits (grape, olive, fig, almond, pomegranate and apple/pear) arrived together in certain areas in spite of uneven distribution and acceptance by local communities. Grape was the crop with the greatest diffusion. The greater diversity of crops in the southern half of the peninsula is also noteworthy. Their development paved the way for a commercial agricultural model in some territories where fruits and their derivatives, such as wine and oil, played vital roles.
Expansion and Specialization of Agricultural Systems in Western Mediterranean Areas: A Global Analysis Based on the Two Last Census Data
Authors: Rabelo Marya , Debolini Marta , Villani Ricardo , Sabbatini Tiziana , Silvestri Nicola
Published: May 2021

The study aims to describe and interpret the agricultural system dynamics on the Western Mediterranean areas in terms of occupied land and crop specialization, by using the available data from the two last agricultural censuses. From the spatial point of view, we chose to adopt the most detailed level available, by using the smallest land administrative unit (LAU) for every involved country (Spain, Portugal, France and Italy). The resulting database was made of about 16k records and seven fields for a total of 112k single data. The considered variables were: total farm area (TFA), utilized agricultural area (UAA), irrigated area (IA), arable lands (AL), permanent crops (PC), permanent grassland (PG) and remaining surface (RS). The LAU data analysis was carried out following the four steps: (i) level of land occupation by agricultural systems; (ii) patterns of crop groups in UAA composition; (iii) attribution to each LAU of an agricultural typology (AT), resulting from the combination of the two previous features and iv) calculation of two synthetic indices to evaluate the expansion and specialization level for each LAU. Finally, an analysis of the spatial distribution of the two indices was proposed. Results showed a lowering over time of the TFA, UAA and PG areas and an increase of IA and RS. The number of identified ATs was rising at the expense of their extension. This phenomenon led to a fragmentation in ATs spatial distribution within the same geographical region. These changes prove that farmers’ responses to the driving forces acting on agricultural systems have been more differentiated than in the past. The prevailing strategy seems to aim at a reduction in the level of specialization of the agricultural systems whereas less marked was the lowering of their level of expansion.
Soil Enzymatic Activities and Microbial Community Structure in Soils Polluted with Tetracycline Antibiotics
Authors: Santás-Miguel Vanesa , Díaz-Raviña Montserrat , Martín Angela , García-Campos Elena , Barreiro Ana , Núñez-Delgado Avelino , Álvarez-Rodríguez Esperanza , Arias-Estévez Manuel , Fernández-Calviño David
Published: May 2021

A laboratory experiment was performed to examine the medium-term influence of three tetracycline antibiotics (chlortetracycline, CTC; tetracycline, TC and oxytetracycline, OTC) at different concentrations in four agricultural soils with similar pH and different soil organic content. After a 42-days incubation period, three different soil enzymes (β-glucosidase, urease, and phosphomonoesterase) were estimated, as well as the phospholipid fatty acids (PLFAs). A residual effect was observed on all microbial parameters measured in the four soils affecting to the soil enzymes activity and soil microbial communities structure (PLFA pattern). A different microbial sensitivity to antibiotics was detected depending on both, soil type and the microbial property considered. Specifically, in general, no antibiotic effect or even a slight positive effect was observed for phosphomonoesterase and β-glucosidase enzyme activities, respectively, while a negative effect was detected for urease activity values, particularly at higher doses of the antibiotics in a soil with a low organic matter content. The principal component analysis performed with the PLFAs data obtained for all soil samples showed different microbial communities depending mainly on soil type, followed by the antibiotic added to the soil (CTC, TC or OTC) and, in a lesser extent, by its concentration. In general, the PLFA patterns showed similar microbial communities structure due to OTC and TC addition in comparison to the microbial communities structure of soil treated with CTC. These results could be environmentally relevant, especially as regards potential effects of antibiotics on the soil microbiome and hence on health risk assessment of these antibiotics in soils.
Multiple Country Approach to Improve the Test-Day Prediction of Dairy Cows’ Dry Matter Intake
Authors: Tedde Anthony , Grelet Clément , Ho Phuong , Pryce Jennie , Hailemariam Dagnachew , Wang Zhiquan , Plastow Graham , Gengler Nicolas , Froidmont Eric , Dehareng Frédéric , Bertozzi Carlo , Crowe Mark , Soyeurt Hélène ,   on behalf of the GplusE Consortium
Published: May 2021

We predicted dry matter intake of dairy cows using parity, week of lactation, milk yield, milk mid-infrared (MIR) spectrum, and MIR-based predictions of bodyweight, fat, protein, lactose, and fatty acids content in milk. The dataset comprised 10,711 samples of 534 dairy cows with a geographical diversity (Australia, Canada, Denmark, and Ireland). We set up partial least square (PLS) regressions with different constructs and a one-hidden-layer artificial neural network (ANN) using the highest contribution variables. In the ANN, we replaced the spectra with their projections to the 25 first PLS factors explaining 99% of the spectral variability to reduce the model complexity. Cow-independent 10 × 10-fold cross-validation (CV) achieved the best performance with root mean square errors (RMSECV) of 3.27 ± 0.08 kg for the PLS regression and 3.25 ± 0.13 kg for ANN. Although the available data were significantly different, we also performed a country-independent validation (CIV) to measure the models’ performance fairly. We found RMSECIV varying from 3.73 to 6.03 kg for PLS and 3.69 to 5.08 kg for ANN. Ultimately, based on the country-independent validation, we discussed the developed models’ performance with those achieved by the National Research Council’s equation.
Keeping Stallions in Groups—Species-Appropriate or Relevant to Animal Welfare?
Authors: Gehlen Heidrun , Krumbach Katrin , Thöne-Reineke Christa
Published: May 2021

This literature review was aimed at analyzing whether stallion husbandry in groups is possible and desirable or poses risks. This was determined on the basis of different studies in order to be able to give practical recommendations from the viewpoint of animal welfare. Consequently, 50 different sources were analyzed, as well as observations of an experiment of the Swiss National Stud on the subject of change from single-stallion to group husbandry and its influence on animal welfare. The results revealed that stallion husbandry in groups is possible but still rarely practiced. It was found that 6% of stallions in 2003, more than 11% in 2012, and nearly 23% of the stallions in 2015 were kept in groups. Furthermore, studies showed that the still widespread individual husbandry of stallions has a negative impact on psyche and body health. Almost half of all stallions showed undesirable patterns of behavior, mostly stallions in individual housing. In addition, many of the latter stallions had problems with their respiratory, digestive, and musculoskeletal systems, which improved when the husbandry conditions of the horses were changed, with the exception of the problems with the digestive system. Conversion into group husbandry is possible, as revealed by an experiment by the Swiss National Stud with a socialization of active breeding stallions outside the breeding season. Therefore, the widespread fear of serious injuries for stallions housed in groups was refuted and the aggressive behavior of the stallions decreased rapidly. Success rates for group husbandry are influenced by the individual character of the stallion, previous experience of the stallion, changes in the group, qualification and management of the farm, and organization of the group housing and husbandry system. This enables species-appropriate husbandry in groups while also considering animal welfare without stress, disadvantages, and serious injuries for stallions.