bluuebunny/crossref_metadata_2025 huggingface dataset:
A study establishing sensitivity and accuracy of smartphone photography in ophthalmologic community outreach programs: Review of a smart eye camera
Authors: Andhare Pooja , Ramasamy Kim , Ramesh Rahul , Shimizu Eisuke , Nakayama Shintaro , Gandhi Preethika
Published: June 2023

Purpose:

Diseases affecting the cornea are a major cause of corneal blindness globally. The pressing issue we are facing today is the lack of diagnostic devices in rural areas to diagnose these conditions. The aim of the study is to establish sensitivity and accuracy of smartphone photography using a smart eye camera (SEC) in ophthalmologic community outreach programs.

Methods:

In this pilot study, a prospective non-randomized comparative analysis of inter-observer variability of anterior segment imaging recorded using an SEC was performed. Consecutive 100 patients with corneal pathologies, who visited the cornea specialty outpatient clinic, were enrolled. They were examined with a conventional non-portable slit lamp by a cornea consultant, and the diagnoses were recorded. This was compared with the diagnoses made by two other consultants based on SEC videos of the anterior segment of the same 100 patients. The accuracy of SEC was accessed using sensitivity, specificity, PPV, and NPV. Kappa statistics was used to find the agreement between two consultants by using STATA 17.0 (Texas, USA).

Results:

There was agreement between the two consultants to diagnosing by using SEC. Above 90% agreements were found in all the diagnoses, which were statistically significant (P-value < 0.001). More than 90% sensitivity and a negative predictive value were found.

Conclusion:

SEC can be used successfully in the community outreach programs like field visits, eye camps, teleophthalmology, and community centers, where either a clinical setup is lacking or ophthalmologists are not available.
Outcomes of preloaded toric intraocular lens implantation in eyes undergoing phacoemulsification
Authors: Nagpal Ritu , Shakkarwal Chetan , Ahsan Saima , Maharana Prafulla Kumar , Goel Madhav , Sharma Namrata
Published: June 2023

Purpose:

To evaluate the clinical outcomes of preloaded toric intraocular lens (IOLs) implantation in eyes undergoing phacoemulsification.

Methods:

This prospective study included 51 eyes of 51 patients with visually significant cataracts and corneal astigmatism ranging between 0.75 and 5.50 D. All patients underwent phacoemulsification with SupraPhob toric intraocular lens implantation under topical anesthesia. The main outcome measures were uncorrected distance visual acuity (UDVA), residual refractive cylinder, spherical equivalent, and IOL stability at 3 months follow-up.

Results:

At 3 months, 49% (25/51) of patients had UDVA equal to or better than 20/25 with 100% of eyes achieving better than 20/40. Mean logMAR UDVA improved from 1.02 ± 0.39, preoperatively to 0.11 ± 0.10 at 3 months follow-up (P < 0.001, Wilcoxon signed-rank test). The mean refractive cylinder improved from − 1.56 ± 1.25 D preoperatively to − 0.12 ± 0.31 D at 3 months follow-up (P < 0.001) while the mean spherical equivalent value changed from − 1.93 ± 3.71D preoperatively to − 0.16 ± 0.27D (P = 0.0013). The mean root mean square value for higher order aberrations was 0.30 ± 0.18 μm while the average contrast sensitivity value (Pelli-Robson chart) was 1.56 ± 0.10 log unit, at the final follow-up. The mean IOL rotation at 3 weeks was 1.7 ± 1.61 degrees, which did not change significantly at 3 months (P = 0.988) follow-up. There were no intraoperative or postoperative complications.

Conclusion:

SupraPhob toric IOL implantation is an effective method for addressing preexisting corneal astigmatism in eyes undergoing phacoemulsification with good rotational stability.
Outcomes of 8 × 8 mm osteotomy in powered external dacryocystorhinostomy
Authors: Goel Ruchi , Ojha Sweta , Gaonker Tanvi , Shah Shalin , Meher Ravi , Arya Deepanjali , Khanam Samreen , Kumar Sushil
Published: June 2023

Purpose:

To study the endoscopic ostium characteristics and outcome of 8 × 8 mm osteotomy in external dacryocystorhinostomy (DCR) using the microdrill system.

Methods:

This prospective interventional pilot study was performed on 40 eyes of 40 patients with primary acquired nasolacrimal duct obstruction (NLDO) from June 2021 to September 2021 in patients undergoing external DCR. An 8 × 8 mm osteotomy was performed using round, cutting burr attached to a microdrill system. Success was defined as patent ostium on lacrimal syringing (anatomical) and a Munk score <3 (functional) at 12 months. Postoperative endoscopic ostium evaluation was done using a modified DCR ostium (DOS) scoring system at 12 months.

Results:

The mean age of the study participants was 42.41 ± 11.77 years and the male-to-female ratio was 1:4. The mean duration of surgery was 34.15 ± 1.66 minutes and that for osteotomy creation was 2.5 ± 0.69 minutes. The mean intraoperative blood loss was 83.37 ± 11.89 ml. Anatomical and functional success rates were 95% and 85%, respectively. The mean modified DOS score was “excellent” in 34 patients (85%), “good” in 1 patient (2.5%), “fair” in 4 patients (10%), and “poor” in 1 patient (2.5%). Complications included nasal mucosal injury in 10% (4/40) of patients, complete cicatricial closure of ostium in 2.5% (1/40), incomplete cicatricial closure in 10% (4/40), nasal synechiae in 5% (2/40), and canalicular stenosis in 2.5% (1/40).

Conclusion:

An 8 × 8 mm–sized osteotomy created by powered drill and covered by lacrimal sac–nasal mucosal flap anastomosis in external DCR is an effective technique that has minimal complications and shorter surgical time.
Long-term Complete Remission of Decitabine-Primed Tandem CD19/CD22 CAR-T Therapy with PD-1 and BTK Inhibitors Maintenance in a Refractory Primary Central Nervous System Lymphoma Patient
Authors: Zou Rui , Zhou Xiao , Liu Hailing , Wang Peng , Xia Fan , Kang Liqing , Yu Lei , Wu Depei , Jin Zhengming , Qu Changju
Published: June 2023

Primary central nervous system lymphoma (PCNSL) is a rare and aggressive non-Hodgkin’s lymphoma that affects the brain, eyes, cerebrospinal fluid, or spinal cord without systemic involvement. The outcome of patients with PCNSL is worse compared to patients with systemic diffuse large B-cell lymphoma. Given potential mortality associated with severe immune effector cell-associated neurotoxicity syndrome (ICANS), patients with PCNSL have been excluded from most clinical trials involving chimeric antigen receptor T-cell (CAR-T) therapy initially. Here, we report for the first time to apply decitabine-primed tandem CD19/CD22 dual-targeted CAR-T therapy with programmed cell death-1 (PD-1) and Bruton’s tyrosine kinase (BTK) inhibitors maintenance in one patient with multiline-resistant refractory PCNSL and the patient has maintained complete remission (CR) for a 35-month follow-up period. This case represents the first successful treatment of multiline resistant refractory PCNSL with long-term CR and without inducing ICANS under tandem CD19/CD22 bispecific CAR-T therapy followed by maintenance therapy with PD-1 and BTK inhibitors. This study shows tremendous potential in the treatment of PCNSL and offers a look toward ongoing clinical studies.
On the realization space of the cube
Authors: Adiprasito Karim , Kalmanovich Daniel , Nevo Eran
Published: June 2023

We prove that the realization space of the

d

-dimensional cube is contractible. For this we first show that any two realizations are connected by a finite sequence of projective transformations and normal transformations. As an application we use this fact to define an analog of the connected sum construction for cubical

d

-polytopes, and apply this construction to certain cubical

d

-polytopes to conclude that the rays spanned by

f

-vectors of cubical

d

-polytopes are dense in Adin’s cone. The connectivity result on cubes extends to any product of simplices, and further it shows that the respective realization spaces are contractible.
Feasibility Analysis and Break Even Point Celery Farming (Apium graveolens L.) Hydroponic Deep Flow Technique (DFT) System (Case Study on a Farmer in Kayuambon Village, Lembang District, West Bandung Regency)
Authors: Hardiyanto Tito , Riswana Rena , Arneta Arneta
Published: June 2023

Medicinal properties. The celery plant also contains many apiin glycosides (flavone glycosides, isoquercetin, and umbelliferons. It also contains, mannite, inocytes, asparagine, glutamine, choline, linamarose, pro vitamin A, vitamin C, and B. This study aims to determine the cost, R/C Ratio, break-even point (BEP) of celery hydroponic farming system with deep flow technique (DFT). The analysis method used in this study is quantitative analysis by calculating and detailing the analysis of costs, income and receipts, feasibility, and break-even points. The results showed that the cost of the hydroponic agricultural system was Rp. 2,213,720.6. The R/C Ratio is 1.01, so the agricultural system is feasible. The break-even point (BEP) for receipts amounted to Rp. 2,160,006.45 while real receipts amounted to Rp. 2,224,800. This means that this agricultural system still benefits Rp. 64. 733.55. The break-even point for production is 184.48 Kg, while the actual production is 185.4 Kg. This means that production provides a benefit of 0.92 Kg. Break-even point selling price is Rp. 11,940.24/Kg while the actual selling price is Rp. 12,000/Kg. This agricultural system provides benefits of Rp. 60/Kg.
Environmental Relations in Armed Conflict (War) Conditions: Assessment of Damage to the Environment and People
Authors: Popovych Tetiana , Andrushchenko Liliia , Olefir Victor , Shumilo Oleksii , Gorinov Pavlo
Published: June 2023

The purpose of the article was to outline a framework of instructions to determine the amount of damage caused to the environment and people during the armed conflict, and to determine the consequences of such impact on the environment in Ukraine and, internationally. The theoretical and methodological basis of the research is a system of philosophical, general scientific and special methods aimed at obtaining objective and reliable results, in particular: ontological, axiological, integrative and prognostic. It was found that the events of military nature on the territory of Ukraine extremely exacerbated the problem of effectiveness of international and national legal documents. It was established that at the international level since 2014, the state of Ukraine has been defined as an ecological disaster zone. It was determined that there are economic and "environmental" components in the composition of environmental damage. The environmental component is equivalent to moral damage. It is proposed to create (1) special associations for environmental impact assessment after the return of territories under Ukrainian control; (2) an international financial institution to overcome the environmental consequences of armed conflict and occupation; (3) to create a comprehensive system of collecting information on the state of the environment.
Personality characteristics of the participant in an armed or paramilitary unit not provided for by law
Authors: Nazarovich Yarmysh Oleksandr , Ivanovych Khalymon Serhii , Viktorovich Zozulia Yevhen , Petrivna Stepanova Yuliia
Published: June 2023

Through the documentary-based scientific method, the article is devoted to the study of the criminological features of the personality of a participant of a paramilitary or armed unit (ULPAU) not provided by law. In addition, the formation of his criminological portrait (criminal profile) on the basis of socio-psychological and legal classification features is discussed. The value of the determined parameters of the offender's characteristics for the formation of negative social and psychological attitudes has been analyzed and their impact on subsequent criminal activity was considered. A number of conclusions of theoretical and applied character have been formulated, among which the following characteristic features of the criminological portrait (criminal profile) of a participant of the ULPAU: man aged 25-35 years who has Ukrainian citizenship and is Ukrainian by nationality, urban resident, single, childless, has general secondary or vocational education, is unemployed, has not been previously convicted; being a member of the armed unit he guarded the checkpoints and the area of location of the units.
İnsanı Anlamada Farklı Yaklaşımlar: Psikanaliz, Şizoanaliz ve Nefs Kavramı Bağlamında Psikolojik Tahliller
Authors: KAHRAMAN Ferruh
Published: June 2023

Çalışmanın konusu İslâmî ilimler, psikanaliz ve şizoanaliz yaklaşımlarının insanı tanımlamasıdır. Çalışmanın problemi ise, modern ve postmodern teorilerin insanı ele alma biçimlerinin daha çok bedensel olması ve bu tanımlamaların yetersiz kaldığının görülmesidir. Zira modern ve postmodern bilimler nefs, rûh, akıl ve irade gibi insanın manevî özelliklerini ve kul olma boyutunu ihmal etmektedir. Amacı psikanaliz ve şizoanalizin birey tahlillerinin değerlendirilmesi ile İslâm’daki nefs tanımından yola çıkarak insanın mahiyetinin daha bütüncül bir anlayışla tekrar sorgulanmasıdır. İnsanı tanıma ve anlama konusunda çok önemli veriler sunan modern ve postmodern yaklaşımların eksik kalan spritüel tarafını İslamî ilim anlayışının insan tarifiyle tamamlamak mümkün olacaktır. Böylece insan, farklı bakış açılarıyla ele alınacak, karşılaştırma ve eleştirilerle daha iyi tanımlamalarına ulaşılacaktır. Çalışmanın önemi ise birbirinden farklı üç bilimsel paradigma olan İslâmî, modern ve postmodern teorilerin insan yaklaşımlarının bir arada incelenmesidir. Modern dönemde insanı tanımlamak ve anlamak için yapısalcılık, gestalt, işlevselcilik, davranışçılık ve psikanaliz gibi pek çok yaklaşım geliştirilmiştir. Postmodern dönemde ise bu yaklaşımların eksiklikleri vurgulanarak biyolojik, nörobilimsel, evrimsel, psikodinamik, davranışsal, bilişsel, insancıl, sosyokültürel, eklektik ve şizoanaliz gibi teoriler geliştirilmiştir. İslâm ilim geleneğinde de insanı tanımlamaya ve insanı anlamaya özen gösterilmiş; insan, özellikle nefs, rûh, kalb, akıl, irâde ve müradifleri bağlamında açıklanmaya çalışılmıştır.
Kur'ân-ı Kerîm Perspektifinden Kültürleşme Stratejileri
Authors: TAŞDEMİR Melike
Published: June 2023

Göç, farklı toplumların birbirleriyle etkileşimini içeren tarihsel bir olgudur. Bu etkileşimlerin sağlıklı sonuçlar vermesi ancak toplumların beraber yaşama becerileri ile mümkün olabilmektedir. Beraber yaşama becerilerinin sağlanma süreci kültürleşme kavramı ile ifade edilmiştir. Kültürleşme, farklı toplumların birbirine uyum sağlama süreçlerinde etkili olan bir kavramdır. Kültürleşmenin sağlanmış olması göç sürecinin başarılı bir şekilde yönetilebildiği anlamına gelmektedir. Bu çalışmanın teorik çerçevesini Berry’nin kültürleşme teorisi oluşturmaktadır. Makalenin amacı, kültürleşme yönelimlerinden asimilasyon, ayrışma, bütünleşme ve marjinalleşmenin Kur’ân-ı Kerim’de yer alan yansımalarının ortaya çıkarılmasıdır. Belirtilen amaç doğrultusunda çalışmada, öncelikle John W. Berry’nin ortaya koyduğu kültürleşme modelleri incelenmiş, ardından Kur’ân’ın göç kavramına dair yaklaşımına değinilerek kültürleşme yönelimleri ayetler ışığında ele alınmıştır. Bu araştırmada nicel dökümantasyon analizi kullanılmıştır. Sonuç olarak Kur’ân’ın kültürleşmeye bakış açısını toplumda huzurun sağlanması, kültür ve dinin korunması gibi ilkelerine göre şekillendirdiği anlaşılmıştır.
Kur’ân-ı Kerim’de Yorgunluk Toplumunun İzdüşümleri
Authors: YILTER Nuray
Published: June 2023

İlk insandan itibaren toplumlarda yorgunluk, bitkinlik, gösterişçilik, tükenmişlik gibi durumlar gözlemlenebilmektedir. Bazı dönemlerde farklı yapılarda gözlemlenen ve başta birey sonra ise toplumu etkileyen bu durumların toplumu geçici veya köklü değişikliklere maruz bırakarak ortaya çıktığı görülmektedir. Toplumun yorgunluğu bireysel yorgunluktan farklı olarak büyük kitleleri etkisi altına alarak yeni bir toplum yapısı ortaya koymaktadır. Yorgunluk toplumunda bireyselleşen insanlar, performans öznesi hâline gelerek kendilerinin en yüksek yorgunlukları ile meşgul olmasıdır. Her şeyi yapabileceği motivasyonu taşıyan bireyler, durmadan üretim ve tüketim çarkı içerisinde bulunarak ruhsal durumlarını önemsememeye başlamıştır. Psikolojik rahatsızlıklar, fiziksel rahatsızlıklar ile aynı yöntem ile tedavi edilmemektedir. İnsanların ruhsal dünyasına etki eden bu durumlar dinlerin öğreti ve ilkeleri ile incelendiğinde çözümler ve doğru ilerlemeler sağlayabilmektedir. Çalışmanın amacı “yorgunluk toplumu” kavramından hareketle Kur’ân-ı Kerim’deki izdüşümleri a) aşırı tüketimle gelen yorgunluk, b) toplumsal tektipleştirme ile gelen yorgunluk, c) karşılık bulamamaktan gelen yorgunluk d) aşırı dünyevileşme ile gelen yorgunluk ve e) mal biriktirme (kariyer) sevdası ile gelen yorgunluk bağlamında açıklamaktır. İletişim ve tüketimin hızlandığı postmodern dönemde konu üzerinde derinlemesine çalışmaların yapılmaya başlandığı görülmektedir. Bu çalışmada Kur’an-ı Kerim’de yorgunluk toplumunun varlığı ayetler üzerinden izlenmeye çalışılmıştır.
Using Machine Learning to Protect Social Media Accounts from Spam Emails
Authors: Raj Gaurav , Mishra Mukul , Khan Firoz , Kasaudhan Aman , Singh Chauhan Sansar
Published: June 2023

Spam refers to all forms of bulk, unsolicited, unwelcome digital communication. Spam can be transmitted by text messages, phone calls, social media, or email, which is how it is frequently done. The rise of social media websites like Facebook, Twitter, YouTube, etc. has given spammers increased access to people. Most spam filtering solutions employ text-based algorithms. The fundamental difficulty is classification because it is a significant one. In this study, features are extracted from emails using classifications of rules. To automatically categorize emails, numerous systems have been created, a few of them include systemic decision-making. The use of Bayesian classifiers, networked neurons, support vector machines, and sample-based approaches. A sizable and time-consuming labelled dataset is required for the supervised model training phase. SVM and Naive Bayes, two supervised learning algorithms, outperform other models in terms of spam identification. It provides comprehensive explanations of these methods in addition to several likely areas for future research in spam filtering and detection. Because most spammers employ obfuscation techniques, the rules set need ongoing updating and improvement. Refinement is occasionally necessary, and in most situations, it is automated, so end users have less bother
Bệnh da bóng nước thai kỳ - Pemphygoid gestationis: nhân một trường hợp và hồi cứu y văn
Authors: Huỳnh Minh Nhật , Lê Hà Yến Chi , Phạm Chí Kông , Huỳnh Kim Quang
Published: June 2023

Bệnh da bóng nước tự miễn là một nhóm bệnh bóng nước có triệu chứng đa dạng, cơ chế bệnh sinh đặc trưng bởi sự xuất hiện các tự kháng thể chống lại các protein tham gia liên kết tế bào da dẫn đến hình thành các sang thương bóng nước trên lâm sàng. Mặc dù tỷ lệ hiện mắc bệnh bóng nước trong thai kỳ là hiếm (tỷ lệ mắc bệnh là 1 trên 20.000 đến 50.000 phụ nữ mang thai), nhưng chủ đề này đáng được quan tâm do làm thay đổi quy trình theo dõi thai nghén, gây khó khăn trong việc kiểm soát triệu chứng (ngứa, tổn thương da) cũng như ảnh hưởng tiên lượng sơ sinh. Chẩn đoán phân biệt các tổn thương da bóng nước trong thai kỳ là một thách thức do các triệu chứng lâm sàng thường thay đổi và thiếu các xét nghiệm chẩn đoán xác định. Lựa chọn và sử dụng các thuốc ức chế miễn dịch để điều trị và kiểm soát bệnh cũng cần được cân nhắc cẩn thận. Chúng tôi trình bày một trường hợp bệnh da bóng nước miễn dịch xuất hiện trong thời kỳ mang thai - Pemphygoid Gestationis - thuộc nhóm bệnh da đặc hiệu thai kỳ (Specific Dermatosis of Pregnancy), trong đó phân biệt bệnh chủ yếu dựa trên biểu hiện lâm sàng, chẩn đoán, điều trị, yếu tố nguy cơ kèm theo và tiên lượng.
Biểu đồ tim thai loại II trong chuyển dạ: kết cục thai kỳ và mô hình dự đoán trẻ ngạt
Authors: Nguyễn Thị Cẩm Nhung , Trịnh Trần Xuân Vinh , Nguyễn Thị Yến , Lê Quang Thanh , Nguyễn Hồng Hoa
Published: June 2023

Đặt vấn đề: Biểu đồ tim thai (CTG) loại II theo tiêu chuẩn ACOG là loại thường gặp nhất trên lâm sàng nhưng lại không đặc hiệu cho tình trạng thiếu oxy thai. Nghiên cứu đánh giá kết cục thai kỳ khi CTG loại II, từ đó, khảo sát các yếu tố liên quan đến trẻ ngạt trên đối tượng CTG loại II nhằm nâng cao giá trị dự đoán của CTG loại II, để đạt được mức cân bằng tốt nhất giữa dự hậu sơ sinh tốt và giảm tối đa những can thiệp phẫu thuật không cần thiết.

Mục tiêu nghiên cứu: Xác định tỷ lệ trẻ ngạt, tỷ lệ mổ lấy thai và khảo sát các yếu tố liên quan từ đó xây dựng mô hình dự đoán trẻ ngạt (Apgar 5 phút < 7).

Đối tượng và phương pháp nghiên cứu: Sản phụ vào chuyển dạ có biểu đồ tim thai loại II tại Khoa Sanh - Bệnh viện Từ Dũ, theo dõi kết cục đến lúc sinh. Nghiên cứu mô tả dọc tiến cứu. Đánh giá trẻ ngạt bằng bảng điểm Apgar 5 phút < 7.

Kết quả: Nghiên cứu 960 CTG loại II ghi nhận kết cục trẻ ngạt chiếm tỷ lệ 1,9% KTC 95% (1,0% - 2,7%). Tỷ lệ mổ lấy thai trong chuyển dạ là 50,4%. Xây dựng mô hình dự đoán trẻ ngạt gồm 10 yếu tố: tuổi mẹ, BMI trước mang thai, tiền căn mổ lấy thai, đái tháo đường thai kỳ, thai chậm tăng trưởng trong tử cung, dây rốn quấn cổ thai, gò cường tính, màu sắc nước ối, nhịp giảm muộn và nhịp giảm kéo dài trên CTG. Diện tích dưới đường cong ROC của mô hình là 0,874.

Kết luận: Tỷ lệ trẻ ngạt 1,9%, tỷ lệ mổ lấy thai 50,4% trường hợp CTG loại II. Biểu đồ tim thai loại II đơn thuần không phản ánh hoàn toàn tình trạng suy thai. Mô hình dự đoán trẻ ngạt là sự kết hợp biểu đồ tim thai với bối cảnh lâm sàng cụ thể nhằm nâng cao giá trị chẩn đoán của công cụ này.
Other Sea Star Igkappa Gene Cloning Assay in E. Coli with New Parameters
Authors: Leclerc Michel
Published: June 2023

The plasmid vector pET-28b(+) named “Young” was produced according a work of 2014
(Ref.1). This construct is designed to allow the expression of a 13.6 kDA protein with a Cterminal 6 histag. It is supposed to be an anti-HRP (Horse-Radish Peroxydase protein). This protein was not expressed in first E.coli we attempt to explain this phenomenon.
Subjectivity and?
Authors: Dreier Ole
Published: June 2023

The aim of the paper is to give a brief presentation of an approach to developing the conception of subjectivity in psychology. This conception is developed on the background of the science of the subject of critical psychology as founded by Holzkamp (1983) which considers subjectivity as a core concept in human psychology. In the conception presented in this paper, it is argued that human subjectivity must be grasped as grounded in a subject’s ongoing situated participation and conduct of everyday life in and across various, structurally arranged social practices. It is argued why such a conception of subjectivity is necessary and its main concepts are briefly presented. A critical identification of methodological and conceptual inadequacies in narrower notions of the psyche and subjectivity paves the way for the line of arguments leading to this broader conception of subjectivity.
Diagnostico para el diseño del manual administrativo de contenido multiple para el gobierno municipal de Tzimol, Chiapas
Authors: Chávez Luis Magín Gómez , Zúñiga José Antonio Aranda , Lessieur Caralampio Faustino Culebro , Lessieur Guadalupe del Carmen Culebro
Published: June 2023

Los manuales administrativos constituyen un medio de comunicación en las organizaciones, fortaleciendo al recurso humano para la realización de sus actividades y generando efectividad, productividad y calidad en las mismas. Es por ello que el Instituto Nacional para el Federalismo y Desarrollo Municipal en su programa “Agenda para el Desarrollo Municipal” trata de fortalecer a los gobiernos municipales, con dichos manuales, para que se conviertan en una administración pública municipal de calidad y al considerarse como el gobierno más cercano a la población se convierte en una obligación, señalada en la Ley de Transparencia y Acceso a la Información Pública  del Estado de Chiapas, el publicarlos en los portales de transparencia.
Effects of guar gum supplementation in high-fat diets on fish growth, gut histology, intestinal oxidative stress, inflammation, and apoptosis in juvenile largemouth bass (Micropterus salmoides)
Authors: Zhao Xiaoyu , Chen Weijun , Tian Erjie , Zhang Yuanyuan , Gao Xiaochan , Huang Yong , Ren Hongtao , Chang Kuo , Sun Ping , Gao Shiyang
Published: June 2023

The present study aimed to investigate the influence of guar gum supplementation in high-fat diets on the growth performance and intestinal oxidative stress, inflammation, and apoptosis of juvenile largemouth bass. Five isonitrogenous diets were prepared: a control diet (10% crude lipid, C), a high-fat diet (17% crude lipid, HF), and three high-fat diets supplemented with 0.3% guar gum (GG0.3), 1% guar gum (GG1), and 3% guar gum (GG3). Largemouth bass (3.1±0.2 g) were randomly assigned to fifteen tanks (30 fish/tank) and fed for 8 weeks. The results demonstrated that GG0.3 significantly increased specific growth rate (SGR) and increased feed conversion ratio (FCR) compared to HF (P < 0.05). For histology, high-fat diets containing guar gum significantly increased intestinal villus length, villus width, and perimeter ratio, compared with HF (P < 0.05). Compared with Control, HF significantly decreased reduced glutathione (GSH) contents and increased malondialdehyde (MDA) contents in the intestine (P < 0.05). Additionally, HF significantly increased the expression of interleukin 1β (IL-1β), tumor necrosis factor α (TNF-α), and cysteine-aspartic proteases 9 (Caspase 9) in the intestine (P < 0.05). Compared to HF, GG0.3 significantly decreased MDA contents, increased GSH contents, and downregulated the expression of IL-1β, TNF-α, and Caspase 3 than diet HF in the intestine (P < 0.05). These results suggest that guar gum can alleviate the adverse effects of high-fat diets on growth and gut health in fish.
L$^{\infty}$ Decay Estimate for the Klein-Gordon Equation in the Anti-de Sitter Model of the Universe
Authors: YAZICI Muhammet
Published: June 2023

We consider the inital value problem for the Klein-Gordon equation with non-zero initial data in anti-de Sitter spacetime. $L^{\infty}$ decay estimate is derived for the solutions to the linear Klein-Gordon equations in the anti-de Sitter spacetime without source term.
A New Approach to Technical Analysis of Oil Prices
Authors: AKBIYIK Mücahit , YAMAÇ AKBIYIK Seda , TURA Ümit , ERER Elif , ÇALIŞ Mehtap , KAYA Ferudun
Published: June 2023

The aim of this study is to investigate the oil prices, which have crucial impact of an economy, using new ratios called Nickel ratios instead of the golden ratios on technical analysis. The Nickel ratios are developed considering Nickel Fibonacci sequence. This study is the first to use Nickel ratios in technical analysis in economics and finance. In this study, graphs comprising of weekly, daily, $4-$hour and $30-$minute periods are analyzed using Nickel ratios in Fibonacci retracement, fan, arcs and time zones applications, and the results are compared with the golden ratio obtained from the Fibonacci number sequence. In addition, the support and resistance points obtained from Nickel ratios have more significant levels than the golden ratio. The retracement, fan, arcs and time zones graphs with weekly, daily, four hourly and half-hourly data based on the golden and Nickel ratios show that the levels regarding the Nickel ratios confirm more significant points in comparison with the levels regarding the golden ratios. Finally, more efficient results are observed when the ratios of golden and Nickel are considered together.
Padovan, Perrin and Pell-Padovan Dual Quaternions
Authors: İŞBİLİR Zehra , GÜRSES Nurten
Published: June 2023

In this present study, we intend to determine the Padovan, Perrin and Pell-Padovan dual quaternions with nonnegative and negative subscripts. In line with this purpose, we construct some new properties such as; special determinant equalities, new recurrence relations, matrix formulas, Binet-like formulas, generating functions, exponential generating functions, summation formulas, and binomial properties for these special dual quaternions.
Sharia External Financing Alternatives for Business Expansion Study Case: PT. XYZ
Authors:   School of Business and Management, Institut Teknologi Bandung, Indonesia, Wirawati Nurul Intan , Noveria Ana ,   School of Business and Management, Institut Teknologi Bandung, Indonesia
Published: June 2023

This study investigates sharia compliance external sources of financing for SME’s business expansion. The object of this study is PT. XYZ that operates in the security service business entity of outsourcing industry. In the last five years until 2022 XYZ has declined in number of clients growth. Fortunately, in 2023 XYZ received an offer to supply 500 security personnel that will increase its sales growth to 134%. This growth is a lot higher than the internal and sustainable growth rate of the company, and hence it needs external financing of IDR 5.2 Billion to support the business expansion. The data collected in this research is through primary and secondary data from a semi-structured interview, five years of financial reports and desk research method. This study examines three alternatives of external Sharia financing namely Islamic Bank financing, Sukuk Issuance and Stock Issuance. XYZ needs to choose one alternative that makes the financial performance of the company healthy and also provides the most worthy risk-return to the equity holders. According to the financial ratios, DCF company valuation and risk-return analysis, this study finds that Sukuk is the best alternative external source of financing for XYZ because it makes the financial performance of the company healthy and also provides a desirable returns for the shareholders with lower risks. XYZ and others SMEs could use this alternative source of external financing to support business expansion. Sukuk can be issued through a funding campaign within a specified period in an authorized and credible Islamic Securities Crowdfunding (I-SCF) platforms.
Prevalence of Dental Caries and Related Factors among Patients Attending Dental Clinics in Dentistry Department - Hilla University College, Iraq
Authors:   Hilla University College, Dentistry Department, Babylon, Iraq, Sarhan Abdulridha Taha , Adnan Mohammad ,   Hilla University College, Dentistry Department, Babylon, Iraq, Hassan Hawra ,   Hilla University College, Dentistry Department, Babylon, Iraq, Hassan Haider ,   Hilla University College, Dentistry Department, Babylon, Iraq
Published: June 2023

Background: Dental caries is the most common dental health problem caused by bacteria that affecting the teeth of huge population worldwide. Many factors are contribute in the prevalence and evolution of caries, such as standard of living, behavior, hygiene, eating habits, social status and socio-demographic factors. Aim: This study aimed to determine and assess the prevalence, frequency and pattern of dental caries and associated factors among patients attending the dental clinics in dentistry department - Hilla University College, Babylon, Iraq. Method: An institution based cross-sectional study was conducted among 924 systematically selected patients attending dental clinics in Dentistry Department - Hilla University College, Babylon, Iraq from Oct./2021 to Apr./2022. The data were collected using pre-tested questionnaire form and oral examination by a qualified dental professional basic hygienic procedures were applied during an oral examination. Results: A total of 924 patients affected with dental caries that were being more in females nearly two-thirds 578 (62.6 %) and in males nearly one-thirds 346 (37.4 % ). Dental caries was lower among respondents who had good oral hygiene status, non- smokers, with blood group AB. Dental caries was higher among respondents rural than urban. Conclusions: Prevalence of dental caries was high and found as public health problem. Socioeconomic status, educational level, and poor oral hygiene practices were associated factors for dental caries. Health promotion about oral hygiene and integration of services are supremely important for the prevention of the problem of dental caries. Smokers patients, who taking sweets, antibiotics and corticosteroids are among the higher cases.
Plastic-Reconstructive Hand Surgery: a Multidisciplinary Procedure
Authors:   Hospital General de Zona #2 Dr. Efrén Correa Magallanes, Fresnillo, Zacatecas, México, Rivas Héctor Adrián Salas , Rivas Jessica Sahory Rios ,   Universidad Juarez del Estado de Durango, Durango, México., Cervantes Axel Fabián Vidales ,   Hospital General Regional #1 Vicente Guerrero del Instituto Mexicano del Seguro Social Acapulco, Guerrero, México, Vargas Daffne Manuel Román ,   Universidad Michoacana de San Nicolás de Hidalgo. Morelia, Michoacán, México, Urzua Irisdey Espinoza ,   Universidad Nacional Autónoma de Mexico, Ciudad de México, México
Published: June 2023

The present study aims to provide a detailed and accurate summary of reconstructive aesthetic hand surgery in medical terms. This specialized surgical intervention comprehensively addresses the functional and aesthetic alterations affecting the hand, through complex and personalized techniques.Aesthetic reconstructive hand surgery is indicated in a variety of clinical situations, including hand trauma, congenital malformations, degenerative diseases, soft tissue defects, tumors and post-surgical reconstruction. Each case requires a thorough and personalized evaluation to determine the most appropriate surgical approach and to achieve satisfactory results.The anatomical complexity of the hand, consisting of bones, joints, tendons, muscles, nerves and blood vessels, requires in-depth knowledge on the part of the surgeon. The multidisciplinary approach, in collaboration with specialists in plastic surgery, orthopedic surgery, occupational therapy, physiotherapy and rehabilitative medicine, is crucial to the success of the intervention.Aesthetic reconstructive hand surgery seeks to restore hand function, improve aesthetic appearance and ultimately improve patients' quality of life. The focus is on repair and reconstruction of affected tissues, correction of deformities, stabilization of joints, revision of scars, and optimization of hand shape and contour
A Review on Hepatotoxic Effects of Methotrexate Therapy with Possible Strategies that May Counteract Hepatotoxicity
Authors:   College of Dentistry, Mustansiriyah University, Iraq, Manna Mohammed J , Jabur Murtadha S ,   College of Pharmacy, National University for Science and Technology, Iraq., Alsabah Atheer S. ,   College of Pharmacy, Al-Bayan University, Iraq., Baqir Luma Saad ,   College of Dentistry, Mustansiriyah University, Iraq
Published: June 2023

Methotrexate, inhibitor of a dihydrofolate reductase, is a chemotherapeutic treatment applied in many kinds of tumors as an anti-metabolite. also, Methotrexate applied to treat different other disorders, including diseases of autoimmunity, such as psoriasis, rheumatism, vasculitis and ulcerative colitis and Crohn’s disease. However, Methotrexate induces toxic effects on neurons, kidney toxicity, and liver damage, also Methotrexate have been associated with elevation risk of hepatic injury, fibrosis and cirrhosis. Methotrexate work as a dihydrofolic acid analog that binds to the dihydrofolate reductase enzyme that prevent the synthesis of tetrahydrofolic acid, that is essential synthesis of DNA. Although folic acid combine with Methotrexate therapy to prevent hepatotoxic effects, folic acid may reduce therapeutic effects of Methotrexate so recent research focus incorporation of new agent to counteract Methotrexate induced hepatotoxicity that include vitamin B12, vitamin E, N-acetylcysteine, melatonin, Erdosteine, inulin, Ferulic acid, Human placental extract, Natural plant extract (flavonoids). These agents are promising to counteract Methotrexate induced hepatotoxicity. Materials and methods: A comprehensive literature review on different published articles hepatotoxic effects of methotrexate and was carried out by electronic research on Medline, PubMed, Google scholar, and Cochrane Libran data bases using different searching terms related to prevention of methotrexate induced hepatotoxicity. The article focusses on clinical studies in different regions in the period of 2018-2022. Objective: To search for new update modality preventive therapy for methotrexate induced liver damage Results: Recent study oriented for the prevention and treatment of methotrexate associated with hepatotoxicity.
Viral Marketing on Consumer Reviews of Selected Carbonated Soft Drinks Companies in Nigeria
Authors:   Department of Business Administration and Marketing, Babcock University, Ilishan-Remo, Ogun State, Nigeria, E. C. Agu, , E. O. Ajike, ,   Department of Business Administration and Marketing, Babcock University, Ilishan-Remo, Ogun State, Nigeria, A.D Adefulu, ,   Department of Business Administration and Marketing, Babcock University, Ilishan-Remo, Ogun State, Nigeria
Published: June 2023

The Carbonated Soft Drinks (CSD) market has continued to grow in leaps and bounds amidst fierce competition for supremacy in the market place. They hold tenaciously to the leadership position in the soda market, having successfully shrugged off challenge from competitors with a combination of product quality, relentless consumer engagement and aggressive advertising. However, studies have established that CSD are faced with persistent purchase decrease over incidents related to negative consumer reviews. Studies indicated that CSD companies tend to prioritize traditional advertising over viral marketing despite the potential benefits of the latter. Therefore, this study investigated the effect of viral marketing on consumer reviews of selected CSD companies in Nigeria. Survey research design was adopted for this study. The population was 3,987 employees in sales and marketing departments of the selected CSD companies in Nigeria. The sample size of 518 was determined using Cochran’s formula. Simple random sampling technique was adopted in selecting respondents. A structured and validated questionnaire was used to obtain data with Cronbach’s alpha reliability coefficients for the constructs ranged between 0.76 and 0.98. The response rate was 82.8%. Data were analyzed using Partial least square Structural equation modelling. The results, however, revealed that electronic word of mouth (β = 0.156, t = 2.168, p < 0.05), Influencer (β = 0.149, t = 2.793, p < 0.05), Reliability (β = 0.164, t = 2.065, p < 0.05) and social media (β = 0.336, t = 4.749, p < 0.05), have a positive and significant effect on the Consumer Review of some selected carbonated soft drink in Nigeria. Based on the findings, this study concluded that viral marketing affected consumer reviews of selected CSD companies in Nigeria. Therefore, this study recommended that management of CSD companies should focus on informativeness, electronic word of mouth, influencer, reliability and social media to enhance consumer reviews.
Improving Learning Management Systems to Better Assist Computer Science Teaching in Qatar Higher Education Institutions
Authors:   Mathematic Department, Lusail University, Doha, Qatar, Alkhateeb Dr. Mais , Alokla Prof. Mosa ,   Teaching & Learning Coordinator, Community College of Qatar CCQ, Doha, Qatar, Alokla Eng. Mohammad ,   Frankfurt am Main, Germany, Alokla Msr.Eng. Eisa ,   TU Darmstadt, Mainz, Germany
Published: June 2023

Hybrid learning first appeared in the late 1990s as a new way of teaching for distance learning that used computers and the internet to improve students' learning and encourage teachers to change their teaching techniques, resulting in a shift in learning from a teacher-centered model to a more student-centered model. This study will contribute to theory, practice, empirical and policy. Theoretically, the study considers the investigate the mediating effect of human resource information system on effect of perceived usefulness, perceived enjoyments, hybrid attitude, hedonic motivation, learning experience, and engagement, on satisfaction in Community College of Qatar (CCQ). Furthermore, as a result of the COVID-19 epidemic, many postsecondary schools have moved to online delivery and learning, forcing many instructors to experiment with online and HL approaches, such as online multimedia and video presentations. In comparison to traditional face-to-face techniques or pure online settings, current research has largely verified that HL is seen to be beneficial (Hill et al., 2017) and has the potential to boost student happiness (Owston et al., 2013).
PENGARUH KOMPENSASI DAN KEPUASAN KERJA TERHADAP KINERJA KARYAWAN PRODUKSI DI PT. BUANA TUNAS SEJAHTERA
Authors: D. P. Cristian  , R. Sesario  , T. C. W. A. Sutignya
Published: June 2023

Compensation and job satisfaction are factors that affect employee performance in achieving a company's goals. Employee performance is one of the factors that influence a company's success rate. This study aims to determine the effect of compensation and job satisfaction on the performance of production employees at PT. Buana Tunas Sejahtera. The purpose of this study was to discover how the effect of compensation and job satisfaction on the performance of PT. Buana Tunas Sejahtera Seriang Mill located in Kapuas Hulu Regency, Badau District. The Multiple Linear Regression uses Analysis with a sample of 30 respondents production employees. Research analysis tool is a questionnaire with a Likert scale using SPSS version 22. The results in this compensation study did not affect employee performance with negative t test results, then job satisfaction had a significant effect on employee performance with positive T test results. Compensation and job satisfaction together have a significant positive effect on employee performance.
UJI RESISTENSI KLON-KLON INTRODUKSI TERHADAP PENYAKIT GUGUR DAUN Pestalotiopsis sp. DI LABORATORIUM
Authors: Didi Kusnedy  , Eka Bobby Febrianto  , Sayurandi  , Cici Indriani Dalimunthe
Published: June 2023

Tanaman karet (Hevea brasiliensis) berasal dari negara Brazil. Pohon karet pertama kali hanya tumbuh di Amerika Selatan. Perkebunan karet di Indonesia mulai diperkenalkan sejak tahun 1864, yaitu sejak Hofland mendirikan perusahaan perkebunan karet di Tanah Panunukan dan Ciasem, Jawa Barat. Serangan yang diakibatkan oleh penyakit Pestalotiopsis sp. menunjukkan bercak cokelat pada daun karet dan adanya batas yang jelas antara bagian bercak dengan bagian daun yang masih sehat. Daun yang terinfeksi gugur sebelum waktunya. Umumnya yang terserang berat adalah tanaman karet yang sudah menghasilkan dan tidak terawat. Penelitian bertujuan untuk mengetahuai tingkat resistensi beberapa klon introduksi yaitu PB 217, PB 260, PB 330, PB 340, RRIC 100, IRR 220 dan GT 1 terhadap penyakit gugur daun yaitu Pestalotiopsis sp. Penelitian dilakukan di Laboratorim Proteksi Tanaman Balai Penelitian Sungai Putih menggunakan Rancangan Acak Lengkap (RAL) non faktorial. Hasil penelitian menunjukkan bahwa pada pengamatan 8 hari setelah inokulasi (hsi) intensitas serangan tertinggi ditemukan pada klon PB 217 dan GT 1 yaitu sebesar  89,9%6 dan 89,96%, sedangkan intensitas serangan terendah terdapat pada klon IRR 220  yaitu sebesar 81,64%.
Multimodality in EAP Objectives and Practice
Authors: SEZGİN Hatice
Published: June 2023

Academic discourse is complex and dense regarding the information it conveys by nature. This complexity requires more effective ways of communication, which is possible by utilizing different modes of meaning–in other words, multimodality. English for Academic Purposes (EAP) aims to prepare learners for the academic discourse that they will be exposed to during their studies. Accordingly, multimodality has become one of the skills learners require to develop during their EAP experiences. This study attempts to reveal how much multimodality is included in EAP objectives and practices. For that purpose, target skills defined for academic English by the Global Scale of English (GSE) (Pearson, 2019) are analyzed to study the multimodal aspect of objectives. For the practice aspect, the tasks in two EAP course books are analyzed using a qualitative approach. The results of the analyses revealed that the use of multiple modes is set as an objective skill for EAP learners within the descriptors of GSE, especially for academic speaking, and this expectation is reflected within the tasks designed in EAP coursebooks. These findings are in agreement with the assumption that multimodality is considered a necessity for academic contexts and, therefore, EAP.
Transformação da máxima precipitação diária para estabelecimento de equações de chuvas intensas: nova proposta
Authors:   , Almeida Laura Thebit de
Published: June 2023

O conhecimento do comportamento das intensidades máximas das chuvas é fundamental para o dimensionamento de estruturas hidráulicas, planejamento do uso da terra e dos recursos hídricos, previsão de desastres, dentre outros. A forma mais adequada de caracterização das chuvas intensas em determinada localidade é por meio das curvas de intensidade, duração e frequência (IDF), ajustadas a partir da análise de pluviogramas. Apesar de sua importância, no Brasil há disponibilidade de apenas 373 equações de IDF ajustadas desta forma. Outra alternativa é por meio da desagregação das chuvas de um dia, por meio do Método de Relação de Chuvas de Diferentes Durações (rcdd), que utiliza coeficientes de desagregação de chuvas específicos para cada duração e com características locais. Entretanto esse método também apresenta a limitação de um conjunto restrito de coeficientes de desagregação para o território brasileiro. Assim, o presente estudo propõe o método da Transformação da Máxima Precipitação Diária (tmdp), baseado no uso de coeficientes de transformação (ct) da máxima lâmina de chuva diária em intensidade máxima de precipitação, para posterior estabelecimento de equações IDF. O método utiliza-se da relação entre as intensidades máximas obtidas por equações de IDF disponíveis em literatura com a máxima lâmina de chuva diária de estações pluviométricas. Os resultados obtidos foram promissores, os erros entre os métodos foram aproximados, com média do RMSE em torno de 17 mm h -1 . O método proposto mostrou-se mais promissor em regiões do país que apresentam maior densidade de informação da equação de IDF, apresentando melhores resultados comparados às demais regiões de baixa e média densidade de equações de IDF. Palavras-chave: Chuva. Intensidade-Duração-Frequência. Pluviométrico. Pluviográfico.
68Ga-DOTA-peptide PET/CT for radiotherapy planning and evaluating treatment response in the management of meningiomas
Authors: Sharjeel Usmani  , Anjali Jain  , Syed Furqan Hashmi  , Layth Mula-Hussain  , Khulood Al Riyami  , Sofiullah Abubakar  , Muhammad Shahzad Shamim
Published: June 2023

Meningiomas overexpress somatostatin receptors (SSTR). PET imaging with SSTR ligands such as 68Ga-DOTA-peptide has recently shown high diagnostic accuracy in identification of meningiomas due to lack of normal bone and brain activity. PET-derived parameters, especially gross tumour volume (GTV) delineation improves inter-observer variability and appears to be particularly promising for RT planning. The potential strength of 68Ga-DOTA in the ongoing assessment of treatment response and disease progression in meningioma, particularly in the post-surgical and post-radiation settings is encouraging. More prospective randomized studies with large cohorts of patients are required to define the effective role of this modality.

Keywords: 68Ga-DOTA PET/CT; Meningioma; 177Lu-DOTATATE; PET/CT; radiotherapy planning.