bluuebunny/crossref_metadata_2025 huggingface dataset:
MANAGEMENT OF INNOVATIVE DEVELOPMENT OF TOURISM ENTERPRISES UNDER THE CONDITIONS OF STRENGTHENING OF GLOBALIZATION PROCESSES
Authors: BILETSKA IRYNA , ROMANCHUKEVYCH MARIANA ,   Ivano-Frankivsk Educational and Research Institute of Management of West Ukrainian National University
Published: March 2022

The article summarizes the features of world tourism development in the context of strengthening of globalization processes. It is established that the process of managing the innovative development of tourism enterprises should be structured and consistent. The stages of coordination of the management system of innovative development of tourism enterprises with modern tendencies of globalization and functioning of world tourism are determined. Priority measures have been systematized, which will ensure the effective functioning of tourism enterprises and minimize the risks of current activity in the context of strengthening of globalization. Differentiation of priority directions for coordinating the management of innovative development of tourism enterprises with the processes of globalization of world tourism depending on their specialization is carried out. It is concluded that the implementation of the proposed tools for coordinating the management of innovative development of tourism enterprises in the context of globalization creates the preconditions for improving the efficiency of their resource potential under increasing competition in the global tourism market.
Care-Arbeit als Ressource für die Lebensführung
Authors: Häußler Angela
Published: March 2022

Care-Arbeit ist eine wesentliche Voraussetzung für Lebensqualität und gesellschaftlichen Wohlstand. Als strukturell unterbewertete Arbeit sind die Bedingungen für Care-Arbeit krisenhaft. Eine care-sensible schulische Bildung für Lebensführung kann zur Stärkung der Ressource Care-Arbeit beitragen.
Central Adiponectin Signaling – A Metabolic Regulator in Support of Brain Plasticity
Authors: Formolo Douglas A. , Cheng Tong , Yu Jiasui , Kranz Georg S. , Yau Suk-Yu
Published: March 2022

Brain plasticity and metabolism are tightly connected by a constant influx of peripheral glucose to the central nervous system in order to meet the high metabolic demands imposed by neuronal activity. Metabolic disturbances highly affect neuronal plasticity, which underlies the prevalent comorbidity between metabolic disorders, cognitive impairment, and mood dysfunction. Effective pro-cognitive and neuropsychiatric interventions, therefore, should consider the metabolic aspect of brain plasticity to achieve high effectiveness. The adipocyte-secreted hormone, adiponectin, is a metabolic regulator that crosses the blood-brain barrier and modulates neuronal activity in several brain regions, where it exerts neurotrophic and neuroprotective properties. Moreover, adiponectin has been shown to improve neuronal metabolism in different animal models, including obesity, diabetes, and Alzheimer’s disease. Here, we aim at linking the adiponectin’s neurotrophic and neuroprotective properties with its main role as a metabolic regulator and to summarize the possible mechanisms of action on improving brain plasticity via its role in regulating the intracellular energetic activity. Such properties suggest adiponectin signaling as a potential target to counteract the central metabolic disturbances and impaired neuronal plasticity underlying many neuropsychiatric disorders.
Screening of key methylation-driven genes CDO1 in breast cancer based on WGCNA
Authors: Tu Simei , Zhang Hao , Qu Xinjian
Published: March 2022

BACKGROUND: With the rapid development of genomics and molecular biology, not only have biochemical indicators been used as tumour markers, but many new molecular markers have emerged. Epigenetic abnormalities are a new type of molecular marker, and DNA methylation is an important part of epigenetics. OBJECTIVE: This study used weighted gene coexpression network analysis (WGCNA) to analyse key methylation-driven genes in breast cancer. METHODS: The RNA-seq transcriptome data, DNA methylation data, and clinical information data of breast cancer patients were downloaded from The Cancer Genome Atlas (TCGA) database, and the MethylMix R package was used to screen methylation-driven genes in breast cancer. The ClusterProfiler package and enrichplot package in R software were used to further analyse the function and signalling pathway of methylation-driven genes. Through univariate and multivariate Cox regression analyses, methylation-driver genes related to prognostic were obtained, a prognostic model was constructed and prognostic characteristics were analysed. RESULTS: The 17 methylation-driven genes related to prognosis were obtained by the WGCNA method in breast cancer, and the prognostic significance of these methylation-driven genes was determined by transcriptome and methylation combined survival analysis. Analysis of functions and signalling pathways showed that these genes were mainly enriched in biological processes and signalling pathway. Through univariate and multivariate Cox regression analyses, a prognostic model of 5 methylation-driven genes was constructed. CONCLUSIONS: The AUC of the receiver operating characteristic (ROC) curve of this model was 0.784, showing that the model had a good prediction effect. Based on WGCNA screening, it was found that only CDO1 was the key methylation-driven gene for prognosis in breast cancer, indicating that CDO1 may be an important indicator of the prognosis of breast cancer patients.
Organizational attractiveness: Targeting prospective employers on social networking sites
Authors: Kakavand Benjamin , Teimourzadeh Aria , Kakavand Samaneh
Published: March 2022

BACKGROUND: Many business organizations have integrated the use of professional social networking sites into their HR practices in order to communicate with and attract qualified candidates as part of their talent acquisition strategy. OBJECTIVE: The aim of this research is to explore some social and behavioral signals on social networking sites that enhance organizational attractiveness. Grounded in the signaling theory, this paper fills the research gap by investigating new types of signals on public professional social networking sites that can affect organizational attractiveness as an employer. METHODS: In this research, a quantitative research methodology was used. The sample consists of 288 job applicants using social networking sites in Canada. RESULTS: The results highlighted the importance of social and behavioral factors that play a significant role in enhancing organizational attractiveness on professional social networking sites. CONCLUSIONS: The results provide insights and practical suggestions for managers who decide to integrate social networking sites into their practices. Additionally, the findings of this research help the managers to better understand the factors that have an impact on job applicants’ choices of their future job and employer.
IACN: Interactive attention capsule network for similar case matching
Authors: Li Hui , Lu Jin , Le Yuquan , He Jiawei
Published: March 2022

The similar case matching task aims to detect which two cases are more similar for a given triplet. It plays a significant role in the legal industry and thus has gained much attention. Due to the rapid development of natural language processing technology, various deep learning techniques have been applied to similar case matching task and obtained attractive performance. Most existing researches usually focus on encoding legal documents into a continuous vector. However, a unified vector is difficult to model multiple elements of the case. In the real world, cases contain numerous elements, which are the basis for legal practitioners to judge the similarity among cases. Legal experts usually focus on whether the two cases have similar legal elements. It makes this task especially challenging. In this paper, we propose a novel model, namely Interactive Attention Capsule Network (dubbed as IACN). It attempts to simulate the process of judgment by legal experts, which captures fine-grained elements similarity to make an interpretable judgment. In other words, the IACN judges the similarity of the case pairs based on the legal elements. The more similar legal elements of a case pair, the higher the degree of similarity of the case pair. In addition, we devise an interactive dynamic routing mechanism, which can better learn the interactive representation of legal elements among cases than the vanilla dynamic routing. We conduct extensive experiments based on a real-world dataset. The experimental results consistently demonstrate the superiorities and competitiveness of our proposed model.
TSPS: A Topic based Shortest Path Set algorithm for influence maximization
Authors: Duan Xiuliang , Qiu Liqing , Sun Chengai
Published: March 2022

This paper focuses on the influence maximization problem in social networks, which aims to find some influence nodes that maximize the spread of information. Most existing achievements usually adopt a uniform propagation probability, without considering the topic information. Moreover, the classic Independent Cascade Model and its approximations have suffered from much running time. To overcome this limitation, this paper proposed a Topic based Shortest Path Set algorithm (TSPS). Additionally, a comprehensive set of experiments are conducted on large real-world networks, showing that our proposal provides more impressive results in the aspects of influence spread and running time.
Hyperphosphorylated Tau Relates to Improved Cognitive Performance and Reduced Hippocampal Excitability in the Young rTg4510 Mouse Model of Tauopathy
Authors: Xolalpa-Cueva Lorena , García-Carlos Carlos Antonio , Villaseñor-Zepeda Rocío , Orta-Salazar Erika , Díaz-Cintra Sofia , Peña-Ortega Fernando , Perry George , Mondragón-Rodríguez Siddhartha
Published: March 2022

Background: Tau hyperphosphorylation at several sites, including those close to its microtubule domain (MD), is considered a key pathogenic event in the development of tauopathies. Nevertheless, we recently demonstrated that at the very early disease stage, tau phosphorylation (pTau) at MD sites promotes neuroprotection by preventing seizure-like activity. Objective: To further support the notion that very early pTau is not detrimental, the present work evaluated the young rTg4510 mouse model of tauopathy as a case study. Thus, in mice at one month of age (PN30-35), we studied the increase of pTau within the hippocampal area as well as hippocampal and locomotor function. Methods: We used immunohistochemistry, T-maze, nesting test, novel object recognition test, open field arena, and electrophysiology. Results: Our results showed that the very young rTg4510 mouse model has no detectable changes in hippocampal dependent tasks, such as spontaneous alternation and nesting, or in locomotor activity. However, at this very early stage the hippocampal neurons from PN30-35 rTg4510 mice accumulate pTau protein and exhibit changes in hippocampal oscillatory activity. Moreover, we found a significant reduction in the somatic area of pTau positive pyramidal and granule neurons in the young rTg4510 mice. Despite this, improved memory and increased number of dendrites per cell in granule neurons was found. Conclusion: Altogether, this study provides new insights into the early pathogenesis of tauopathies and provides further evidence that pTau remodels hippocampal function and morphology.
Apathy in UK Care Home Residents with Dementia: Longitudinal Course and Determinants
Authors: Sommerlad Andrew , Park Hee Kyung , Marston Louise , Livingston Gill
Published: March 2022

Background: Apathy in dementia is common and associated with worse disease outcomes. Objective: To describe the longitudinal course of apathy in dementia and identify associated sociodemographic and disease-related factors. Methods: Prospective cohort study of UK care home residents with dementia. At baseline, 4, 8, 12, and 16 months, care home staff rated apathy using the Neuropsychiatric Inventory (clinically-significant apathy if≥4), dementia severity, and provided other sociodemographic information about each participant. We examined the prevalence and persistence of apathy and, in mixed linear models, its association with time, age, sex, dementia severity, antipsychotic use, and baseline apathy and other neuropsychiatric symptoms. Results: Of 1,419 included participants (mean age 85 years (SD 8.5)), 30% had mild dementia, 33% moderate, and 37% severe. The point prevalence of clinically-significant apathy was 21.4% (n = 304) and the 16-month period prevalence was 47.3% (n = 671). Of participants with follow-up data, 45 (3.8%) were always clinically-significantly apathetic, 3 (0.3%) were always sub-clinically apathetic, and 420 (36.2%) were never apathetic until death or end of follow-up. In adjusted models, apathy increased over time and was associated with having more severe dementia, worse baseline apathy and other neuropsychiatric symptoms. Conclusion: It is important for clinicians to know that most people with dementia are not apathetic, though it is common. Most of those with significant symptoms of apathy improve without specific treatments, although some also relapse, meaning that intervention may not be needed. Future research should seek to target those people with persistent severe apathy and test treatments in this group.
Alzheimer’s Disease: Key Insights from Two Decades of Clinical Trial Failures
Authors: Kim C. Kwon , Lee Yin Rui , Ong Lynnett , Gold Michael , Kalali Amir , Sarkar Joydeep
Published: March 2022

Given the acknowledged lack of success in Alzheimer’s disease (AD) drug development over the past two decades, the objective of this review was to derive key insights from the myriad failures to inform future drug development. A systematic and exhaustive review was performed on all failed AD compounds for dementia (interventional phase II and III clinical trials from ClinicalTrials.gov) from 2004 to the present. Starting with the initial ∼2,700 AD clinical trials, ∼550 trials met our initial criteria, from which 98 unique phase II and III compounds with various mechanisms of action met our criteria of a failed compound. The two recent reported phase III successes of aducanumab and oligomannate are very encouraging; however, we are awaiting real-world validation of their effectiveness. These two successes against the 98 failures gives a 2.0% phase II and III success rate since 2003, when the previous novel compound was approved. Potential contributing methodological factors for the clinical trial failures were categorized into 1) insufficient evidence to initiate the pivotal trials, and 2) pivotal trial design shortcomings. Our evaluation found that rational drug development principles were not always followed for AD therapeutics development, and the question remains whether some of the failed compounds may have shown efficacy if the principles were better adhered to. Several recommendations are made for future AD therapeutic development. The whole database of the 98 failed compounds is presented in the Supplementary Material.
Efficacy of Chronic Paroxetine Treatment in Mitigating Amyloid Pathology and Microgliosis in APPSWE/PS1ΔE9 Transgenic Mice
Authors: Sivasaravanaparan Mithula , Olesen Louise Ørum , Severino Maurizio , von Linstow Christian Ulrich , Lambertsen Kate Lykke , Gramsbergen Jan Bert , Hasselstrøm Jørgen , Metaxas Athanasios , Wiborg Ove , Finsen Bente
Published: March 2022

Background: Modulation of serotonergic signaling by treatment with selective serotonin reuptake inhibitors (SSRIs) has been suggested to mitigate amyloid-β (Aβ) pathology in Alzheimer’s disease, in addition to exerting an anti-depressant action. Objective: To investigate the efficacy of chronic treatment with the SSRI paroxetine, in mitigating Aβ pathology and Aβ plaque-induced microgliosis in the hippocampus of 18-month-old APPswe/PS1ΔE9 mice. Methods: Plaque-bearing APPswe/PS1ΔE9 and wildtype mice were treated with paroxetine per os at a dose of 5 mg/kg/day, from 9 to 18 months of age. The per os treatment was monitored by recording of the body weights and serum paroxetine concentrations, and by assessment of the serotonin transporter occupancy by [3H]DASB-binding in wildtype mice. Additionally, 5,7-dihydroxytryptamine was administered to 9-month-old APPswe/PS1ΔE9 mice, to examine the effect of serotonin depletion on Aβ pathology. Aβ pathology was evaluated by Aβ plaque load estimation and the Aβ42/Aβ40 ratio by ELISA. Results: Paroxetine treatment led to > 80% serotonin transporter occupancy. The treatment increased the body weight of wildtype mice, but not of APPswe/PS1ΔE9 mice. The treatment had no effect on the Aβ plaque load (p = 0.39), the number and size of plaques, or the Aβ plaque-induced increases in microglial numbers in the dentate gyrus. Three months of serotonin depletion did not significantly impact the Aβ plaque load or Aβ42/Aβ40 ratio in APPswe/PS1ΔE9 mice at 12 months. Conclusion: Our results show that chronic treatment with the SSRI paroxetine does not mitigate Aβ pathology and Aβ plaque-induced microgliosis in the hippocampus of APPswe/PS1ΔE9 mice.
High-speed PMSM thermal analysis of totally enclosed fan cooled axial ventilation for centrifugal blower application
Authors: Abubakar Usman , Wang Xiaoyuan , Haleem Shah Sayyed , Gao Peng , Wang Lixin
Published: March 2022

A temperature rise occurs when an electrical machine is fully loaded. The winding insulations of high-speed permanent magnet synchronous machines (PMSMs) are the most temperature-sensitive components, which can impact the machine’s longevity. Thus, recently, prediction for high-speed PMSM winding temperature has been given more and more attention. Thermal analysis by numerical (computational fluid dynamics (CFD) and finite element method (FEM)) and analytical lumped parameter thermal network (LPTN) methods have been widely used to estimate the temperature of totally enclosed fan cooled axial ventilation system (TEFCAVS) machines. Although numerical methods have more accuracy, their computation wastes time. Therefore, LPTN is being utilized in this paper due to the fastness of its computation. Firstly, estimated losses of high-speed PMSM with TEFCAVS via electromagnetic analysis, including copper, iron, permanent magnet (PM) eddy current, sleeve eddy current, and mechanical, are coupled to the LPTN model, which acts as heat sources for temperature prediction. Moreover, analysis shows that slot windings’ maximum temperature exceeds the winding insulation class with initial cooling configuration. Secondly, in order to mitigate slot winding temperature, the sensitivity study for liner conductivity, air gap’s heat transfer and lamination to housing’s contact is conducted by LPTN to identify which thermal parameter has more influence on mitigating the maximum temperature of the slot winding. Investigation shows that improving an air gap’s heat transfer has more influence than other parameters for mitigating slot winding maximum temperature below its insulation class. Lastly, the machine is designed and tested with the best thermal-sensitive parameters. Then test results for the maximum temperature of the winding are compared with estimated results to ensure the proposed LPTN correctness, and the calibration process confirms LPTN accuracy.
Effect of novel amido ester internal donor on the performance of Ziegler-Natta catalyst for propylene polymerization
Authors: Paghadar Bharatkumar R. , Sainani J.B. , Samith K.M. , Tantry Sudha , Bhagavath Poornima
Published: March 2022

Various classes of molecules like diethers, succinates, diesters, amido esters are currently being used as internal donors on MgCl2 supported titanium catalysts for isotactic polypropylene as an alternative to phthalate donors owing to their potential health risk laid down by REACH legislation. In the present paper, design and synthesis of a few novel amido ester internal donors with single chiral center (7–11) by mimicking the model amido ester 3 having two chiral centers; and their catalyst preparation method were described. Further preliminary polymerization tests with newly synthesized donor molecules were investigated and results revealed that by structurally mimicking 3 with one chiral center and also with varied substitutional patterns in ester/amido moiety decline the polypropylene activity as well as isotacticity. These donor molecules are ineffective for appropriate coordination on MgCl2 sites on inducing steric hindrance for improved isotacticity; nevertheless also induces poisoning effect for the active Ti centers leading to catalyst fouling in many cases.
Influence of concentration of different chemical precursors on the physical properties of Cr2O3 thin films elaborated via pneumatic spray
Authors: Saadi Bothaina , Rahmane Saâd , Laidoudi Mouloud , Kater Aicha
Published: March 2022

In this paper, Cr2O3 thin films were synthesized successfully on glass substrates at 450 °C using a simple and low-cost homemade pneumatic spray system (SP) using two different precursors: chromium chloride and chromium nitrate. A systematic study of the influence of concentration of each precursor used for deposition on the structural, morphological, optical and electrical properties has investigated. The XRD results show that the Cr2O3 films prepared with chromium chloride are polycrystalline with rhombohedral structure and those prepared with low concentration of chromium nitrate have a poor crystallinity. Peaks associated with Cr and O elements are present in EDS analysis that confirm the composition of the films and SEM images revealed a uniform, homogeneous and well covered surface. The measured electrical conductivity was found in the order of 5(Ω.cm)–1. The average transmittance of the films deposited from chromium nitrate is in the range of 60 % and for the films deposited from chromium chloride, it reaches75 % in the visible region. These electrical and optical properties of Cr2O3 thin film ascribed to its wide band gap, are indeed required for optoelectronic devices especially for solar cell window.
Antimicrobial activity of Hydroxyapatite nanoparticles prepared from marble wastes
Authors: Algamal Yousif , Khalil N.M. , Saddiq Amna , Baghdadi Afra Mohammed
Published: March 2022

This work aims to prepare and characterize the hydroxyapatite (HAP) nanomaterials from marble wastes (the utilization of the building marble waste for reducing the environmental pollution hazards) and to study its capabilities as antimicrobial and antifungal agents of the prepared nanoparticle. The utilization of the marble waste as a source for calcium chloride and to be reacted with sodium hydrogen phosphate, for synthetization of hydroxyapatite nanoparticles, the prepared material is characterized, tested, and analyzed using X-ray diffraction (XRD), Scan Electron Microscope (SEM) with Energy Dispersive X-Ray analysis (EDAX) techniques. The antimicrobial activity of prepared hydroxyapatite nanomaterial is tested using a well diffusion method with different types of bacteria (Gram-negative): Escherichia. Coli, Salmonella paratyphi, Pseudomonas earuginosa, and Alcaligenes aquatilis and bacteria (Gram- positive): Staphylococcus aureus, and Streptococcacea pneumonia. The antifungal efficacy of HAP nanoparticles is tested for different species of Aspergillus niger, Aspergillus flavus, and Penicillium SP.

The diameter of the inhibitory zone shows the sensitivity of the microorganism to HAP nanoparticles in a greater inhibition against Gram- positive Staphylococcus aureus and Streptococcacea pneumonia, at 100% DMSO concentration. The diameter of the inhibition zone was 03.70 mm, when compared with other types of bacteria.

The diameter of the inhibitory zone showed the sensitivity of the microorganism to HAP nanoparticles in a greater inhibition against Penicillium SP at 100% DMSO concentration, the inhibition zone diameter was 2.20 mm, when compared with other Aspergillus niger an d Aspergillus flavus fungal species. Based on obtained results for the HAP nanoparticles prepared from the marble wastes have antibacterial effects on both Gram-negative ( E. coli) and Gram-positive ( S. aureus) strains.
Food security association with some risk factors of obesity-related diseases in Ardabil-Iran population
Authors: Mohajeri Mahsa , Mohajery Reza
Published: March 2022

The aim of the study is the assessment of the food security status and its association with some risk factors of chronic obesity-related diseases in Ardabil-Iran population. METHODS: This cross-sectional study was done between 500 adults of Ardabil that were selected by random sampling from Persian cohort study participants, in January 2019. Food insecurity of study participants was measured using the United States Department of Agriculture 18-item questionnaire. Some risk factors of chronic diseases including fasting blood glucose, lipid profile, liver enzymes, and dietary information were measured on the day of the interview. To assess the association between variables the correlation and linear regression tests were used. RESULTS: Forty-eight and six percent of the study participants were food secure and 51.4% were in food insecurity status. There were a significant difference in weight, blood glucose, blood pressure, and serum triglyceride levels between the food security status groups (P < 0.05). The food insecurity score had significant association with participants, weight (p = 0.005,β= 1.66), serum triglycerides (p = 0.022,β= 0.027), body mass index (p = 0.003,β= 0.645) and fasting blood sugar (p = 0.0001,β= 0.664). CONCLUSION: About half of the participants were in food insecurity status. Food insecurity status can be associated with obesity and some risk factors of chronic obesity-related diseases. This problem requires main food policies to reduce food insecurity in the community.
One-year results of minimally invasive fusion surgery of the sacroiliac joint as an alternative treatment after failed endoscopic thermal coagulation
Authors: Soliman Osama , Pflugmacher Robert , Koch Ernst MW , Mohamed Hesham , van der Beck Susanne , Abdallah Hany , Bornemann Rahel
Published: March 2022

BACKGROUND: While pain in the severe sacroiliac joint (SIJ) is a common cause of lower back pain, SIJ disease is often overlooked as a diagnosis. OBJECTIVE: This study examines the extent of sufficient long-term pain relief and functional improvement in patients with SIJ syndrome that are treated with thermocoagulation. Some patients treated with thermocoagulation noted initial improvement, but the functionality and pain relief had limited duration and efficacy. Patients with insufficient improvement were recommended to undergo fusion surgery as an option for better and longer lasting results. METHOD: Patients with a long history of back or pelvic problems were selected for the study. Endoscopic thermal coagulation of the SIJ was carried out. The follow-up examinations took place after 1, 3, 6, 12 months. In patients with insufficient pain relief and functionality after thermocoagulation, a fusion surgery was performed. The results of the fusion surgery were documented over a 12-month follow-up period. To carry out the statistical evaluation visual analog scale (VAS), Oswestry-Disability-Index (ODI) and the consumption of opioids were recorded. RESULTS: Forty-eight patients were included. The mean VAS values 12 months after thermocoagulation were 68.9. The ODI after 12 months was very near or somewhat higher than their baseline prior to the thermocoagulation. Thus, a fusion surgery was recommended. Thirty-three patients agreed to the fusion operation. The VAS values 12 months after fusion surgery decreased to 53.1. Analogous to the VAS values, the Oswestry index (ODI) showed a significant improvement after the fusion operation. CONCLUSION: The success of surgical intervention in 88% of the SIJ syndrome patients with inadequate results 12 months after thermocoagulation proves the superiority of SIJ fusion surgery. This study showed long-lasting pain relief by an average of 65% and a median improvement in functional impairments of 60%. In view of these results, fusion surgery should be considered for patients without sufficient success of thermocoagulation.
RBF network-based adaptive sliding mode control strategy for the tendon-sheath driven joint of a prosthetic hand
Authors: Yin Meng , Huang Binhua , Yi Zhengkun , Cai Shibo
Published: March 2022

BACKGROUND: The complex in-hand manipulation puts forward higher requirements for the dexterity and joint control accuracy of the prosthetic hand. The tendon-sheath drive has important application potential in the fields of prosthetic hand to obtain higher dexterity. However, the existing control methods of tendon-sheath driven joint are mainly open-loop compensation based on friction model, which makes it difficult to achieve high-precision joint control. OBJECTIVE: The purpose of this work is to improve the position control accuracy of the tendon-sheath driven joint for the prosthetic hand. METHODS: The structure of the prosthetic hand is introduced, and the encoder and potentiometer are mounted on the driving motor and joint respectively. Then, the transfer function of the joint is established based on the dynamic model. The adaptive sliding mode control strategy based on RBF network is applied to realize the closed-loop feedback position control of the prosthetic hand joint. The stability of the system is demonstrated by Lyapunov theorem. RESULTS: Under the condition of constant and variable sheath curvature, the effectiveness of the controller is demonstrated by simulation and joint motion experiments, respectively. The results show that the closed-loop control has better position tracking ability than the open-loop control, and the designed controller can reduce the tracking error more obviously than the traditional algorithm. The high-precision position control can be realized by designing the controller based on the joint angle feedback. CONCLUSIONS: The research content has certain theoretical and practical significance for the development of joint high-precision control of tendon-sheath driven prosthetic hand. This is beneficial to the implementation of complex in-hand manipulation for prosthetic hand.
Happy or sad? Recognizing emotions with wavelet coefficient energy mean of EEG signals
Authors: Chen Ruijuan , Sun Zhihui , Diao Xiaofei , Wang Huiquan , Wang Jinhai , Li Ting , Wang Yao
Published: March 2022

BACKGROUND: Emotional intelligence plays a vital role in human-computer interaction, and EEG signals are an objective response to human emotions. OBJECTIVE: We propose a method to extract the energy means of detail coefficients as feature values for emotion recognition helps to improve EEG signal-based emotion recognition accuracy. METHOD: We used movie clips as the eliciting material to stimulate the real emotions of the subjects, preprocessed the collected EEG signals, extracted the feature values, and classified the emotions based on them using Support Vector Machine (SVM) and Stacked Auto-Encoder (SAE). The method was verified based on the SJTU emotion EEG database (SEED) and the self-acquisition experiment. RESULTS: The results show that the accuracy is better using SVM. The results based on the SEED database are 89.06% and 79.90% for positive-negative and positive-neutral-negative, respectively. The results based on the self-acquisition data are 98.05% and 89.83% for the same, with an average recognition rate of 86.57% for the four categories of fear, sad (negative), peace (neutral) and happy (positive). CONCLUSION: The results demonstrate the validity of the feature values and provide a theoretical basis for implementing human-computer interaction.
Fully automatic segmentation of abdominal aortic thrombus in pre-operative CTA images using deep convolutional neural networks
Authors: Wang Yonggang , Zhou Min , Ding Yong , Li Xu , Zhou Zhenyu , Xie Tianchen , Shi Zhenyu , Fu Weiguo
Published: March 2022

BACKGROUND: Endovascular aortic aneurysm repair (EVAR) is currently established as the first-line treatment for anatomically suitable abdominal aortic aneurysm (AAA). OBJECTIVE: To establish a deep convolutional neural networks (DCNN) model for fully automatic segmentation intraluminal thrombosis (ILT) of abdominal aortic aneurysm (AAA) in pre-operative computed tomography angiography (CTA) images. METHODS: We retrospectively reviewed 340 patients of AAA with ILT at our single center. The software ITKSNAP was used to draw AAA and ILT region of interests (ROIs), respectively. Image preprocessing and DCNN model build using MATLAB. Randomly divided, 80% of patients was classified as training set, 20% of patients was classified as test set. Accuracy, intersection over union (IOU), Boundary F1 (BF) Score were used to evaluate the predictive effect of the model. RESULTS: By training in 34760–35652 CTA images (n= 204) and validation in 6968–7860 CTA images (n=68), the DCNN model achieved encouraging predictive performance in test set (n= 68, 6898 slices): Global accuracy 0.9988 ± 5.7735E-05, mean accuracy 0.9546 ± 0.0054, ILT IOU 0.8650 ± 0.0033, aortic lumen IOU 0.8595 ± 0.0085, ILT weighted IOU 0.9976 ± 0.0001, mean IOU 0.9078 ± 0.0029, mean BF Score 0.9829 ± 0.0011. Our DCNN model achieved a mean IOU of more than 90.78% for segmentation of ILT and aortic lumen. It provides a mean relative volume difference between automatic segmentation and ground truth (P> 0.05). CONCLUSION: An end-to-end DCNN model could be used as an efficient and adjunctive tool for fully automatic segmentation of abdominal aortic thrombus in pre-operative CTA image.
SCALE UP PEMBUATAN STARTER BIOGAS: PREPARASI LUMPUR AKTIF UNTUK PRODUKSI BIO-HIDROGEN
Authors: Heriyanti Septina Is , Prasetyo Joni , Murti Galuh Wirama , Sholihah Atti , Adiprabowo Arya Bhaskara
Published: March 2022

POME as liquid waste from palm oil processing has a high organic content so it is suitable for anaerobic digestion process to produce biogas and bio-hydrogen. This study aims to prepare activated sludge from biogas starter which will be used for bio-hydrogen production. The production of biogas starter with cow dung using POME as feed and the addition of nutrients (urea and DAP) at a certain ratio and buffer (soda ash) was carried out in a fermenter with a capacity of 1 m3 using a fed batch system. During one month of fermentation, methane concentration in biogas increased and stabilized until it reached the highest concentration at 33,7%. The fermentation process also produces hydrogen whose concentration decreases with time because hydrogen-producing microbes are dominant at the beginning of the fermentation, but then the hydrogen produced was consumed by methanogenic bacteria to produce CO2 and CH4. This confirmed that the activated sludge produced from the 1 m3 fermenter contained hydrogen-producing bacteria which were then further processed, one of which was heating at a certain temperature, to suppress the growth of methanogenic bacteria.
Analisis Kinerja Turbin Uap Sebelum dan Setelah Proses Overhaul di PT PERTAMINA GEOTHERMAL ENERGY Area Kamojang
Authors: Prastyo Elli , Dhamayanthie Indah
Published: March 2022

One of the important components in geothermal power generation is steam turbines. One of the decreases in steam turbine performance is caused by excessive workload due to continuous operation. Maintenance of steam turbines through important overhauls is carried out to improve the performance of steam turbines. Actual conditions with ideal conditions are important to know and analyze to know the performance of steam turbines. The operational performance of steam turbines at PT Pertamina Energi Geothermal Area Kamojang can be seen from the value of turbine working specifications (Wt), and isentropic efficiency (ηt). Parameters in the form of inlet pressure (P1), outlet pressure (P2), inlet temperature (T1), outlet temperature (T2), and flow rate (m/s) are searched using the ChemicalLogic SteamTab application and linear interpolation methods to determine the value of enthalpy and entropy. The results were obtained that the value of isentropic enthalpy (h2s) before the overhaul amounted to 2,127.41 kJ/kg and after an overhaul of 2,145.91 kJ/kg. Turbine power value (Ẇt) before overhaul was 30,702.88 kW and after overhaul was 36,304.7 kW. Efficiency after overhaul decreased ±1.4% of efficiency before the overhaul.
Temas para Construção de Material Educativo sobre Alimentação da Criança com Leucemia
Authors: Costa Cicero Ivan Alcantara , Pacheco Sandra Teixeira de Araújo , Soeiro Gabriella , Nunes Michelle Darezzo Rodrigues , Silva Liliane Faria da , Peres Patrícia Lima Pereira
Published: March 2022

Introdução: A alimentação é um tema que gera muitas dúvidas nos familiares de crianças com leucemia, e os materiais educativos são fundamentais para preparar e orientar esses cuidadores para o cuidado domiciliar. Objetivo: Identificar os temas sobre a alimentação da criança com leucemia sob a ótica de enfermeiros e familiares cuidadores para construção de material educativo. Método: Pesquisa qualitativa participativa realizada em 2018 por meio de círculos de discussão, em um hospital oncológico no Rio de Janeiro-RJ, com seis familiares e seis enfermeiros, após aprovação dos Comitês de Ética em Pesquisa. Os dados foram analisados pelo método da análise de conteúdo na modalidade temático-categorial. Resultados: As falas dos familiares e enfermeiros subsidiaram o conteúdo para construção de materiais educativos, como cartilha, apontando a necessidade de orientações sobre alimentação oferecida à criança, destacando os seguintes temas: imunidade normal; neutropenia; náuseas e vômitos; mucosite; disgeusia; constipação; diarreia; higiene e forma de preparo dos alimentos. Conclusão: A construção de material educativo para familiares de crianças com leucemia poderá contribuir para sanar as dúvidas dos familiares, uma vez que permitirá aos enfermeiros orientá-los durante a internação de sua criança, servindo posteriormente como um guia para o desenvolvimento dos cuidados de sua criança no domicílio.
Small for gestational age: A risk factor for the development of hypertension in childhood?
Authors: SURPURE SHREYAS , SHARMA SHOBHA , SASTE SONAL , KABRA NANDKISHOR , BAVDEKAR SANDEEP
Published: March 2022

Background: There is conflicting evidence regarding the association of elevated blood pressure and SGA status. Most of the studies showing positive association have demonstrated this association in children aged above 7 years.

Objectives: To determine if there is a significant difference between the proportion of children aged 3-5 years, born-SGA and those born-AGA developing hypertension.

Methodology: The observational cross-sectional study was carried out at a private tertiary care hospital. Clinically healthy children (age: 3-5 years) were enrolled and grouped as those who born-SGA and those who were born AGA. Blood pressure was recorded with oscillometric device and procedure was repeated three times at an interval of at least 10 minutes. The mean of three blood pressure recordings was considered as the participant’s true blood pressure. The demographic characteristics of the study population were summarized using descriptive statistics. Categorical outcomes were compared by using Chi square or Fischer exact test. For continuous outcomes, ‘t test’ was used. P value of less than 0.05 was considered statistically significant.

Results: The study enrolled 27 SGA-born children and 27 AGA-born children. Nine children (33.33%) in the SGA group and one child (3.7%) in the AGA group developed hypertension (p= 0.011).  The systolic blood pressure in the SGA group (103.20±8.62 mmHg) was significantly higher than that in the AGA group (98.58±6.60 mmHg) (p=0.031). The diastolic blood pressure (mean ± SD) in the SGA group was 62.75 ± 9.19 mm Hg. There was no significant difference between the diastolic blood pressures in the two groups (AGA: 59.00±5.11mm Hg, SGA: 62.75 ± 9.19; p= 0.07).

Conclusion: Being born SGA was thus found to be a risk factor for hypertension in 3-5 years old children.
MICROSTRUCTURE, MECHANICAL PROPERTIES AND GEOMETRY
OF A MODEL BATCH OF SEMI-SPHERICAL STEEL LINERS
INTENDED FOR USE IN THE EXTRACTIVE INDUSTRY
Authors: Stepien Jerzy , Burdek Marek , Marcisz Jaroslaw , Zak Artur , Janiszewski Jacek
Published: March 2022

The article presents the results of investigation of the microstructure
and mechanical properties of Fe-based materials intended for
the production of semi-spherical liners for experimental shaped
charges. The tests were carried out on samples taken in three directions
in relation to the rolling direction: 0°, 45° and 90°, of
the following materials: cold-rolled sheets made of DC04 steel,
hot-rolled sheets made of 04J steel, and cold-rolled strips made of
004G steel developed at Łukasiewicz – IMŻ and annealed at 650°C.
Semi-spherical drawpieces with a diameter of 106.4 mm, intended
for liners, were made of the sheets with the use of cold stamping.
Tests of the microstructure and HV hardness of samples taken from
the test batch were carried out on cross-sections along the pressing
direction and the model batch – on sections transverse to the stamping
direction The geometry of the model batch drawpieces was also
measured. The ferrite grain size evaluation was performed according
to the ASTM E112 standard using μgrain software with a grain
size evaluation module using counting the number of intersections
of grain boundaries with a circle.
АКТУАЛЬНІ ПИТАННЯ ЩОДО ЗБЕРЕЖЕННЯ ІНФОРМАЦІЇ ОТРИМАНОЇ ВНАСЛІДОК ВТРУЧАННЯ В ПРИВАТНЕ СПІЛКУВАННЯ
Authors: Ільченко Олександр , Смаль Вікторія
Published: March 2022

Стаття присвячена питанню щодо збереження інформації отриманої під час проведення негласних слідчих розшукових дій внаслідок втручання у приватне спілкування. Важливість цього питання полягає у розбіжності думок науковців щодо використання інформації зібраної шляхом втручання в приватне життя. Адже з одного боку Основний закон України має забезпечувати дотримання державними органами, органами досудового розслідування забезпечення та гарантування конституційних прав громадян, а саме право на недоторканність житла, на таємницю спілкування та на приватне життя. З іншого боку негласні слідчі розшукові дії, обмежують права особи, лише з метою встановлення істини та відновлення конституційних прав потерпілої особи, адже НСРД проводяться лише у тому випадку, коли відомості про кримінальне правопорушення та особу, яка вчинила його, неможливо встановити в інший спосіб.
ОСОБЛИВОСТІ ДИСТАНЦІЙНОГО МЕНЕДЖМЕНТУ ПЕРСОНАЛУ В УМОВАХ ПАНДЕМІЇ COVID-19
Authors: Збрицька Тетяна , Дашян Артем
Published: March 2022

У статті досліджено перехід підприємств у час коронавірусної кризи 2020-2021 років до роботи у дистанційному чи віддаленому режимі, окремо висвітлено перехід менеджменту персоналу до віддаленого способу роботи з працівниками. Актуальність теми визначено нещодавніми змінами роботи більшості підприємств в умовах пандемії COVID-19. Наукова новизна статті визначена практичними рекомендаціями з менеджменту підприємства в умовах дистанційної роботи. Проаналізовано основні переваги та недоліки роботи у ремоут-режимі, надано приклади позитивних та негативних сторін сучасних процесів в умовах пандемії та локдаунів. Окрім цього було зазначено щодо можливості проводити подальші реформи менеджменту персоналу на дистанційній основі та підприємств навіть після закінчення коронавірусної пандемії. Надано практичні пропозиції для імплементації реформ та покращення діяльності підприємства з утримання та мотивації співробітників. Запропоновано поради з управління персоналом, установлення цілей та задач працівників й активної допомоги в адаптації персоналу до дистанційної роботи. Також висвітлено методи боротьби з професійним вигоранням та немотивованістю працівників. Запропоновано більш ефективні комунікації між управлінським персоналом, відділом кадрів (HR-департаментом) та рядовими працівниками компаній.
ПРИСТОСУВАЛЬНІ ОСОБЛИВОСТІ КЛІЩА VARROA DESTRUCTOR ТА УДОСКОНАЛЕННЯ ПРОТИВАРООЗНИХ ЗАХОДІВ
Authors: Мусієнко Олексій , Кистерна Олеся , Скляр Олександр , Гузєва Валерія
Published: March 2022

У роботі детально вивчений річний цикл розвитку кліща Varroa destructor у різних за силою бджолиних сімей. Як і більшість арахнід, до яких відноситься ектопаразит медоносних бджіл, він має спеціальні розселювальні та переживаючи фази. Так як і бджолина сім’я, вирощує в зиму бджіл з тривалим строком життя, так і кліщ змінюється на період зимівлі. Самки кліща, що виведені у червні-липні живуть менше ніж ті, що вирощені восени. Встановлена участь трутневого розплоду медоносних бджіл у зростанні популяції кліща. Пояснюється природній шлях боротьби бджолиної сім’ї з кліщем. Експериментально доведена ефективність різних зоотехнічних прийомів зниження екстенсивності інвазії протягом сезону та порівняння її з протиакарицидними обробками. Доведена необхідність постійного моніторингу екстенсивності інвазії та необхідність девастації наприкінці головного медозбору.
РУХОВА АКТИВНІСТЬ ЯК НЕВІД’ЄМНА СКЛАДОВА ЗДОРОВ’Я СТУДЕНТІВ
Authors: Городинський Сергій
Published: March 2022

Інтенсифікація навчального процесу у вищих навчальних закладах освіти, збільшення об’єму інформації для самостійної творчої роботи, збільшення психічних навантажень гостро поставили питання про впровадження в повсякденне життя студентів фізичної культури та спорту. Більшість учнівської і студентської молоді не піклується в повній мірі про своє здоров’я, а як і доросле населення бачить його крізь призму діяльності лікувальних установ та не звертається до ефективних засобів оздоровлення, якими є фізичні вправи. Тому саме рухова активність є одним з ключових показників фізичного розвитку людини – вона створює сприятливі умови для прояву фізичних якостей і сприяє більш швидкому оволодінню основними руховими та прикладними навичками. Вона слугує винятково важливим, фундаментальним чинником формування, збереження, зміцнення здоров'я та розвитку людини, особливо в дитячому, підлітковому та юнацькому віці.
РОЛЬ САКРАЛЬНОГО МИСТЕЦТВА У ФОРМУВАННІ КОПІЮВАЛЬНИХ УМІНЬ МАЙБУТНІХ ХУДОЖНИКІВ
Authors: Кучма Надія
Published: March 2022

Стаття присвячена проблемі модернізації художньої освіти, завданням якої є підготовка фахівця, озброєного глибокими знаннями в галузі мистецтва і культури, здатного до творчої діяльності. Обґрунтовано значення навички копіювання творів мистецтва як складової компетентностей майбутнього художника, роль відповідної дисципліни в освітніх програмах художніх спеціальностей. Проаналізовано низку праць дослідників педагогічного аспекту копіювання, наведено його визначення, класифікацію копій, описано методику копіювання, що мала місце в процесі становлення розвитку мистецької освіти в Україні, зокрема у майстерні монументального живопису і храмової культури при Національній академії образотворчого мистецтва і архітектури, педагогічний метод професора Української академії мистецтв Михайла Бойчука. Охарактеризовано сучасні вітчизняні та зарубіжні методики копіювання (вправи американської педагогині основоположниці методики правопівкульного малювання Бетті Едвардс), визначено труднощі, що виникають у здобувачів у процесі оволодіння копіюванням, та шляхи їх подолання. Зроблено висновок про те, що серед джерел копіювання не повною мірою використовуються твори сакрального мистецтва, які мають потужний навчальний та виховний потенціал. Аналіз мистецтвознавчої літератури з проблем сакрального мистецтва також засвідчив недостатню увагу до використання творів сакрального мистецтва в освітньому процесі вищої школи. У статті наведене визначення сакрального мистецтва, охарактеризовано його основні ознаки, особливості роботи як над оригіналами, так і копіями. Подано власний досвід викладання копіювання як навчальної дисципліни й добір джерел для копіювання, якими найчастіше є православні ікони. Стаття завершується висновками і пропозиціями, в яких зазначається, що твори сакрального мистецтва мають зайняти належне місце в навчально-методичному забезпеченні підготовки майбутніх художників і вказується на необхідність розробки відповідних методичних рекомендацій.