bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation Of The Results Of Hematological Parameters Of Patients With Gastric Cancer
Authors: GÜL Mehmet Ali , TOZCU Duygu , KURT Nezahat , ÇAPRAZ Mustafa
Published: September 2023

Objective: Gastric cancer is a major health concern which fourth leading cause of cancer death and fifth most common cancer. It has difficulties such as having a poor prognosis and diagnoses at an advanced stage. There are studies to find prognostic indicators that are easily and less invasively obtained in gastric cancer and hematological tests are one of them. In this study, we aimed to investigate the relation between hematological test and gastric cancer.

Materials-Methods: In this study, 48 patients diagnosed with gastric cancer and 45 healthy adults in the control group were examined prospectively. All participants' demographic data and laboratuary results were obtained from the hospital database and recorded.

Results: In the gastric cancer group compared to the healthy control group, while red blood cells (RBC), hemoglobin (HBG), hematocrit (HTC), mean cell hemoglobin concentration (MCHC), platelet distribution width (PDW), lymphocyte (LYM), eosinophil (EU) values were statistically lower, mean corpuscular hemoglobin (MCH), red cell distribution width-standard deviation, red cell distribution width-coefficent of variation (RDW-CV), nucleated red blood cells (NRBC), neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR) and monocyte lymphocyte ratio (MLR) values were observed to be statistically higher (p
La humanización del cuidado en situaciones complejas
Authors:   Universidad Cooperativa de Colombia, Palomino Potes Heidys Paola
Published: September 2023

La presente nota de clase busca que los/as enfermeros/as en formación logren identificar los patrones de conocimiento, las visiones de enfermería y la aplicación de la teoría de Jean Watson a partir de una experiencia de cuidado plasmada en una narrativa. La narrativa es una herramienta que le permite a la enfermería relatar situaciones, actitudes y emociones que han surgido de una relación con el paciente o colectivo. Concede a la enfermería una forma de comprender experiencias de otros, ponerse en el lugar de la persona que narra, de manera que logre interpretar las visiones, los conocimientos y los aspectos teóricos que surgen de la comprensión de los hechos. Las visiones del mundo de la enfermería reflejan cómo el/la enfermero/a interpreta, desde el punto de vista ontológico y epistemológico, el acto de cuidado. Además, los patrones de conocimientos permiten comprender la práctica de enfermería de acuerdo con la manera de pensar e intervenir un fenómeno. En este marco, la teoría del cuidado humano de Watson describe el cuidado transpersonal como un tipo especial de relación entre el/la enfermero/a y el paciente que incluye 10 procesos de caridad (caritas), los cuales contienen una dimensión claramente espiritual y una evocación franca del amor y el cuidado humanizado, entre ellas, que el cultivo de la práctica del amor-bondad y la ecuanimidad hacia uno mismo y los demás es la base de la conciencia de la caridad. Su importancia radica en la sensibilización de los futuros profesionales de enfermería, hacia aspectos más humanos que favorezcan la calidad de atención.
Burslu Öğrencisinin Gözünden Sümerbank: Mustafa Kemal Atatürk’ün Büyük Eseri ve Mirası
Authors: ERDEM İŞMAL Özlenen
Published: September 2023

Bu makalede, Türkiye Cumhuriyeti Devleti’nin kurucusu Büyük Önderimiz Mustafa Kemal Atatürk’ün en önemli eserlerinden birisi olan ve bizzat adını da verdiği Sümerbank’ın modern sanayimizin kurulmasındaki tarihi önemine, toplumun ekonomik, sosyal ve kültürel gelişimindeki çok önemli etkilerine dikkat çekilmiştir. Üniversite lisans ve yüksek lisans eğitimi sürecinde bir Sümerbank burslusu olan yazar, 1986-1997 tarihleri arasında Manisa Pamuklu Mensucat ve İzmir Sümerbank Basma Sanayi Fabrikalarındaki çalışma sürecinde edindiği deneyimleri ışığında Sümerbank’ın kurumsal işleyişini değerlendirmiştir. Atatürk’ün liderliğindeki yurtsever ve özverili kadrolarla 1933 yılında kurulan bu dev kuruluş, birçok konuda ilkleri gerçekleştirmiş, ekonomi tarihimizin temelini oluşturarak çok yönlü bir toplumsal gelişim sağlamıştır. Bir ülkedeki insanların tarihlerini bilmesi, toplumla ilgili her türlü gelişim hakkında tarihi bilgi ve bilince sahip olması gereklidir. Gelişim süreçlerini bilmek, tarihten ders alarak hataları tekrarlamamak, bugün ve geleceğe yönelik çıkarımlar yapmak son derece önemli bir yaklaşımdır. Bu bağlamda, 1987 yılında alınan özelleştirme kararıyla tüm işletmeleri kademeli olarak birer birer kapatılan tarihi mirasımız Sümerbank yeni nesillere anlatılmalı ve unutulmamalıdır. Geride artık sadece adı kalsa da sanayi tarihinde unutulmaz bir yere sahip olan Sümerbank bıraktığı izlerle başta modern Türk tekstil sektörü olmak üzere tüm sanayi dallarının başarı öykülerinde yaşamaya devam etmektedir.
Decolonizing the “state of nature” in political thought
Authors: De Wit Theo
Published: September 2023

The study of coloniality as a “social imaginary” (Charles Taylor) from the perspective of decoloniality invites European scholars, to “think again”, to interrogate their own traditions, including their modern political philosophical tradition. In this article, I will discuss a powerful modern political imaginary, namely the democratic narrative of the “social contract”. Such narratives or “imaginations of our origin” (Ursprungsphantasien: Philip Manow) give us answers to the enigma of our social and political existence: what does it mean to live in this political community? What does it give us, ask from us? In the modern narrative of the “social contract”, we are told that, to be a good citizen, we have/had to leave the “state of nature” (status naturalis), a state often described as a state of disorder, conflict, and war, and accept the status of citizenship (status civilis) and a powerful state as guarantee of peace and the rule of law. In this article, I will firstly give some examples of the use of this narrative in very diverse contexts: 1) in the context of the European religious civil wars in the 16th and 17th centuries (birth of the modern liberal political philosophy), 2) in the context of the transition of European nation-states to the European Union after WWII, 3) in the context of the transition of Apartheid South Africa to a non-racial democracy. Secondly, I will concentrate on one of the first philosophers who introduced the state of nature/civil state narrative, Thomas Hobbes (1588–1679), to discover that his political imagination is deeply influenced by the colonial experience in the “New World”, especially the meeting with the indigenous Indians in America. In several aspects, they are in Hobbes’ imagination the incarnation of the life in the “state of nature”. This raises the question, how the idea of a democratic social contract can be reformulated, without Eurocentric and racist premises, and without simply reversing the Hobbesian narrative: since the “colonizer” is the root of our conflict and controversies, to expel him will restore a durable peace.
Cura vocalis.
Authors: Wepener Cas , Wepener Clara
Published: September 2023

In this article the fields of speech and language pathology and of homiletics join hands to explore the theological and spiritual aspects of preaching in combination with the aspects influencing voice production in the (South) African context; this is done to highlight the importance of reflexivity/self-awareness and the self-care of preachers. The main aim of the article is to promote the need for a distinctly (South) African cura vocalis by exploring factors that influence preaching and use of voice in this context. This aim is pursued by firstly describing preaching as a performance that involves the whole human body. The article then describes and discusses the challenges that preachers face in the (South) African context. These homiletical and contextual insights are augmented with insights from the domain of speech and language pathology, which includes a brief description of the main organs involved in voice production and how voice works, along with factors that have an impact on voice production and vocal quality. The final section presents the need for a cura vocalis in the service of a cura homiletica, which promotes early intervention to deal with voice pathologies related to the practice of preaching as well as methods to prevent such pathologies from developing.
Genetic predictors of Peyronie’s disease: review
Authors: Epifanova M. V. , Kostin A. A. , Gameeva E. V. , Ikonova K. R. , Artemenko S. A. , Epifanov A. A. , Chernykh V. B.
Published: September 2023

Peyronie’s disease (PD) is a benign fibrous lesion in the albuginea of the penis that can occur in men of various ages. Despite the fact that epidemiological and pathophysiological data on PD are contradictory, there are a number of comorbidities that suggest a genetic predisposition to this pathology. Genetic and molecular studies of PD are insufficient and their results are often contradictory. This literature review will consider the most studied and potential genetic predictors of PD, namely: transforming growth factor β1, myostatin, matrix metalloproteinases, Wnt signaling pathway, microRNAs (MiR-29b), major histocompatibility complex proteins (human leukocyte antigen). Expanding the possibilities of early diagnosis of the disease will increase the effectiveness of the treatment.
Assessment of the kidney functional state prior and after partial nephrectomy for a unilateral tumor using mathematical processing of computed tomography data with contrast enhancement
Authors: Proskura A. V. , Alyaev Yu. G. , Borisov V. V. , Butnaru D. V. , Rapoport L. M. , Sirota E. S. , Suvorov A. Yu. , Fiev D. N. , Shpot E. V. , Bezrukov E. A. , Enikeev M. E. , Akopyan G. N. , Korolev D. O. , Vorobiev A. A. , Chernenkiy M. M. , Chernenkiy I. M. , Ismailov Kh. M. , Shomukimova Z. S.
Published: September 2023

Background. According to the contemporary data available contrast-enhanced computed tomography can be used to assess total and split kidney function. The Urology Clinic of the I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University) utilizes mathematical processing of computed tomography data for the assessment of split kidney function.

Aim. To evaluate the effect of main renal artery clamping (warm ischemia time) during partial nephrectomy for a unilateral tumor on the kidney function.

Materials and methods. 33 patients of both sexes who underwent partial nephrectomy for unilateral kidney tumor were enrolled in the study. Prior to and 3–6 months after the surgery, 3D glomerular filtration rate (GFR), 3D perfusion, 3D volume of the renal parenchyma were evaluated by mathematical processing of computed tomography data with contrast enhancement. As well as that the dynamics of the total GFR (CKD-EPI equation) and total volume of the kidneys were assessed.

Results. No significant changes were registered for both general functional renal parameters (creatinine level, total GFR, total volume of functioning renal parenchyma) and split 3D GFR. There were significant differences in 3D perfusion and kidney parenchyma volume prior and after partial nephrectomy.

Conclusion. The results of the research highlight good reserve capacity the kidneys after partial nephrectomy with main renal artery clamping. The evidence that the non-operated kidney takes over the function of the resected kidney is based on the fact that there is an increase in its perfusion and volume of the kidney in the postoperative period. This state can also be regarded as a redistribution of functional loads between the kidneys, which is an adaptive mechanism in the postoperative period.
Information Processing view of Electricity Demand Response Systems: A Comparative Study Between India and Australia
Authors:   Indian Institute of Technology Madras, Sangeeth L R Silpa , Mathew Saji K. ,   Indian Institute of Technology Madras, Potdar Vidyasagar ,   Curtin University
Published: September 2023

Abstract Background: In recent years, demand response (DR) has gained increased attention from utilities, regulators, and market aggregators to meet the growing demands of electricity. The key aspect of a successful DR program is the effective processing of data and information to gain critical insights. This study aims to identify information processing needs and capacity that interact to improve energy DR effectiveness. To this end, organizational information processing theory (OIPT) is employed to understand the role of Information Systems (IS) resources in achieving desired DR program performance. This study also investigates how information processing for DR systems differ between developing (India) and developed (Australia) countries. Method: This work adopts a case study methodology to propose a theoretical framework using OIPT for information processing in DR systems. The study further employs a comparative case data analyses between Australian and Indian DR initiatives. Results: Our cross case analysis identifies variables of value creation in designing DR programs - pricing structure for demand side participation, renewable integration at supply side, reforms in the regulatory instruments, and emergent technology. This research posits that the degree of information processing capacity mediates the influence of information processing needs on energy DR effectiveness. Further, we develop five propositions on the interaction between task based information processing needs and capacity, and their influence on DR effectiveness. Conclusions: The study generates insights on the role of IS resources that can help stakeholders in the electricity value chain to take informed and intelligent decisions for improved performance of DR programs.
Identifying the Determinant Dimensions of Shopper Convenience for Online Versus Instore Shopping in the Pre and Post CoVID-19 Eras
Authors:   Texas Tech University, Kakar Ashish , Kakar Adarsh Kumar ,   Alabama State University
Published: September 2023

Abstract Background: Shopper convenience is a key determinant of why shoppers choose and buy from a particular retail format – online versus instore. However, there are no systematic studies that assess which dimension of shopper convenience is salient for shoppers in online versus instore shopping instore. Further, to the best of our knowledge no study has investigated whether and how these determinant dimensions of shopper convenience have changed with the advent of COVID-19. Method: In this study, 1324 responses of 172 shoppers using the Myers and Alpert (1968) approach were analyzed to identify the determinant dimensions of convenience for online and instore shopping in the pre-COVID-19 era and test their validity in the context of their actual purchase behavior. Later, the study was replicated with the same shoppers in the post-COVID-19 era. Results: The results of the study show that of the four dimensions of convenience, while shopper assessment of “search” convenience was the most important attribute for both online and instore shopping, and “transaction” convenience the most different between the two retail outlets, the determinant dimensions in both retail outlets were “access” and “possession” convenience with instore shopping holding an advantage in possession” convenience and online shopping holding an advantage in “access” convenience. However, in a replication of the study in the post coronavirus era, online shopping outlets were found to have the advantage in both the determinant dimensions of convenience. Conclusion: This study perhaps for the first time show how shopper convenience perceptions have changed in pre and post COVID-19 eras for both instore and online shopping.
CONSTRUCTION AND IMPLEMENTATION OF THE IDENTITY POLICY IN UKRAINE IN 2022–2030: ANALYSIS AND FORECASTING MODEL
Authors:   Ivan Franko Lviv National University (Lviv) Ukraine, Bevza Bohdan , Hincul Andrij ,   Yury Fedkovich Chernivtsi National University (Chernivtsi) Ukraine
Published: September 2023

The principles and content of identity policy are defined, including the main functions, subjects and areas of implementation, as well as processes and instruments of identity policy. The state of affairs in the field of identity policy for 2023 is analyzed in the main environments of its implementation — discourses of communities, institutions, regulatory documents and external representation. In the discourse of regulatory documents, a hierarchical system of regulatory acts is currently being formed, aimed at the formation and implementation of state policy in the sphere of establishing Ukrainian national identity as a component of ensuring Ukraine’s national security. At the same time, the next aspect of regulatory regulation should be the «construct» — the fixation of valuable and principled elements of Ukrainian national identity as the consequences of intellectual decisions, social consensus, discursive practices, behavioral practices, and cultural traditions. The visionary model of Ukrainian national identity and the visionary model of identity policy in Ukraine are proposed in the perspective of 2030. The key problems that need to be solved in order to achieve the desired results in the field of identity politics are identified.
THE PRACTICE OF APPLYING ELECTORAL TECHNOLOGIES DURING PRESIDENTIAL ELECTORAL CAMPAIGNS: UKRAINIAN EXPERIENCE
Authors:   Kamianets-Podilskyi Ivan Ohiienko National University (Kamianets-Podilskyi) Ukraine, Vinnichuk Olha , Kobylnyk Vasyl ,   Kamianets-Podilskyi Ivan Ohiienko National University (Kamianets-Podilskyi) Ukraine
Published: September 2023

The work carried out a systematic study of the practice of using electoral technologies during presidential campaigns in Ukraine. The concept of electoral technologies as a tool to influence public opinion has been analyzed. The peculiarities of electoral technologies development in Ukraine during the period of independence have been highlighted and analyzed in stages. It is claimed that in the context of modern society digitalization, the approach to the use of technology in electoral campaigns is changing significantly. An important place in the recent electoral (presidential and parliamentary) campaigns was played by the latest electoral technologies, including the use of social networks. The advantages and disadvantages of their implementation have been outlined. Despite the tendency to use the latest electoral technologies, traditional electoral technologies (talk shows, debates, etc. ) remain quite effective. The «dirty» electoral technologies that were used during the presidential election campaigns in Ukraine have been detailed. Among them, the most popular were: «double» technology, «clone», «revolutionary» technologies, «bribery of voters», image-building, disinformation technologies, fakes (deep fake), etc. It should be noted that the technologies of «performance» and theatricalization of the election process played a rather important role in the successful conduct of the presidential election campaign. It is noteworthy that the effectiveness of the applied electoral technologies depends on human and material resources, the qualities of the leader himself and the team of specialists.
REGARDING THE EFFICIENCY OF LOCAL SELFGOVERNMENT
Authors:   National University of Bioresources and Nature Management (Kyiv) Ukraine, Semenchenko Fedir
Published: September 2023

The article analyzes the process of formation of local self-government in Ukraine, determines the level of its effectiveness and opportunities for improvement. Local self-government is understood as a set of non-political relations in society, as the right of territorial communities to independently resolve economic, social, legal, moral, religious, national and other issues of local importance, which is implemented directly through local self-government bodies — councils, bodies of self-organization of the population, public organizations and associations, and territorial assemblies. The analysis of the main laws on local self-government in Ukraine showed that the organizational, legal and financial foundations of local self-government have been created, but legal regulation has not led to the separation of powers of local self-government bodies and local executive authorities, which are subordinated to district or regional state administrations, the heads of which are appointed by the President. The forms of local self-government have been clarified. It is noted that there has been no real local self-government, as state administrations mostly serve the ruling elite and business elite, and communities are excluded from their proper functions. This scenario has historical roots, but it is doomed because it hinders the development of civil society. The solution to this contradiction is seen in changing the relationship between the state and society, through broad decentralization.
MODERN TRENDS IN REGIONAL DEVELOPMENT MANAGEMENT IN UKRAINE
Authors:   V.M. Koretsky Institute of state and law of National Academy of Sciences of Ukraine (Kyiv) Ukraine, Kachmarskyi Yevhenii
Published: September 2023

Regional policy is always about balanced and sustainable development of regions, constructive competition between regions, and ultimately, the creation of poles of socio-economic growth. The military invasion of the Russian Federation into Ukraine undermines many achievements in regional development management. The focus of regional policy in Ukraine has been forced to shift from searching for innovative components to create points of socio-economic growth to policies aimed at rebuilding and restoring critical infrastructure and basic living conditions. The current realities faced by the regions necessitate a revision of the provisions of the State Strategy for Regional Development for 2021–2027 (hereinafter referred to as the State Strategy), regional strategies, and strategies for the development of territorial communities. Additionally, it is necessary to determine a new mechanism for the utilization of funds from the state regional development fund. The war has created a new and unique situation in the regional development of Ukraine, characterized by significant changes in the political, socio-economic, security, and environmental spheres of life in the occupied, de-occupied, and unaffected regions that have been influenced by the war in one way or another. This situation requires new approaches to regional policy to address existing problems and tasks. The modern trends in regional development management in Ukraine have been identified, the impact of decentralization reforms on regional development has been analyzed, and the transformation of institutional support for territorial development and the prospects of regulatory and legal support for regional development management have been studied.
INSTITUTIONAL CHANGES OF THE LUTSK CITY COUNCIL UNDER THE CONDITIONS OF DECENTRALIZATION
Authors:   Lesya Ukrainka Volyn National University (Lutsk) Ukraine, Bortnikova Alla
Published: September 2023

The analysis of the evolution of the institutional structure of the Lutsk City Council in the conditions of administrative and territorial reform on the basis of decentralization in 2014–2023 has been carried out. Quantitative and qualitative changes of its executive committee, departments, administrations, offices and commissions, depending on the socio-economic development of the country and the policy of the central government have been shown. Attention has been focused on the processes of decentralization, which are accompanied by the transfer of powers of state authorities to localities. The progress of the implementation of the tasks «Concept of reforming local self-government and organization of territorial power in Ukraine», the requirements of the laws of Ukraine «On access to public information», «On state registration of legal entities and individuals», «On the authorization system in the sphere of economic activity», Resolutions of the Cabinet of Ministers «On the town-planning cadastre», etc. has been revealed. The positive changes that took place during the researched period in the activities of the Lutsk City Council in the direction of greater transparency, controllability and accountability to the territorial community have been proven. The positive experience of the city council in bringing services closer to the city population through a specially created department − the Center for the provision of administrative services in the city of Lutsk has been attested. With the aim of providing the Armed Forces of Ukraine, territorial defense units, other military formations, internally displaced persons and communities in need of humanitarian aid with food and non-food items, the Lutsk central aid point has been operating in the city since February 25, 2022.
Development and Validation of New Methods for Quality Control of the Antiviral Substance FAVIPIRAVIR
Authors:   A.V. Bogatsky Physico-Chemical Institute of the National Academy of Sciences of Ukraine, Odesa, Ukraine, Scrypynets Yu.V. , Fedosenko G.O. ,   "ІNTERCHEM", Odesa, Ukraine, Maltsev G.V. ,   "ІNTERCHEM", Odesa, Ukraine, Chebotarska I.I. ,   A.V. Bogatsky Physico-Chemical Institute of the National Academy of Sciences of Ukraine, Odesa, Ukraine, Aleksandrova D.I. ,   A.V. Bogatsky Physico-Chemical Institute of the National Academy of Sciences of Ukraine, Odesa, Ukraine, Kashutskуy S.N. ,   "ІNTERCHEM", Odesa, Ukraine, Yegorova A.V. ,   A.V. Bogatsky Physico-Chemical Institute of the National Academy of Sciences of Ukraine, Odesa, Ukraine
Published: September 2023

The introduction into the production of medicinal substances involves the creation of a pharmaceutical dossier, an important component of which is data on pharmaceutical development and quality control methods. The physico-chemical properties of the antiviral substance of favipiravir were investigated, and some basic sections of the analytical documentation were developed. With the help of a complex of physical, chemical, and physico-chemical methods of analysis, the "Identification" test was developed, and the structure of favipiravir was proven. Methods for the determination of related substances by the HPLC with UV detection and the assay of favipiravir by the acid-base titration method, suitable for substance quality control, have been developed. Relative retention times and correction factors for calculating their content are established for all impurities. The methods were validated on the parameters of specificity, accuracy, correctness, and linearity in the studied range of concentrations.
Extraction of Alkaloids by the Micellar Phase of Sodium Dodecyl Sulfate for their Further Chromatographic Determination
Authors:   Taras Shevchenko National University of Kyiv, Ukraine, Starova V.S. , Kulichenko S.A. ,   Taras Shevchenko National University of Kyiv, Ukraine
Published: September 2023

The influence of the main parameters of hydrophobicity (log P), structure (PSA), and protolytic properties (pKa) of some alkaloids on their distribution into modified micellar extraction system based on sodium dodecyl sulfate (SDS-NaCl-H2Sal) was established. The proposed prognostic regression D= 941 – 4.09∙PSA – 27.3∙log P – 44.5∙рКа is characterized by satisfactory indexes (R-squared 99.9, F-ratio 242, standard error 7.19, mean absolute error 2.38). The accuracy of the alkaloid distribution prediction by this regression is well correlated with accuracy of the measurement of the extraction parameters. The predicted D value for novocaine is 257 (R = 93 %), and the experimentally found D value is 202 (R = 91 %). For lidocaine, the predicted and experimental D values are practically the same and equal 386 (R = 95 %) and 380 (R = 95 %), respectively. The possibility of quantitative extraction of positively charged hydrophilic (logP < 0) organic bases into the micellar phase of SDS is shown. The developed hybrid HPLC technique for determining papaverine in urine with its cationic form (pH=2) preconcentration by modified micellar SDS phase is characterized by sufficient sensitivity and accuracy (DL= 0.01 μg/ml, Sr ≤ 0.08, R > 99 %, K = 10). Only alkaloids with log P > 1.4 can be determined by this technique because otherwise, the chromatographic peaks of salicylic acid and alkaloid cannot separate.
HPLC-pharmaceutical Analysis of Lantibiotic Nisin in the Industrial Samples Including Expired Sample
Authors:   Mechnikov Institute of Microbiology and Immunology of the National Academy of Medical Sciences of Ukraine, Kharkiv, Ukraine, Martynov Artur , Knysh Oksana ,   Mechnikov Institute of Microbiology and Immunology of the National Academy of Medical Sciences of Ukraine, Kharkiv, Ukraine
Published: September 2023

Nisin is the most well-known representative of subtype A1 lantibiotics. This small (< 5 kDa) peptide ribosomally produced by Gram-positive bacteria belonging to Lactococcus, Streptococcus, Staphylococcus and Blautia species. Nisin exhibits antibacterial activity against a broad range of Gram-positive bacteria and may be effective against Gram-negative pathogens. For analytical semi-preparative purposes, gradient HPLC is often used in the acetonitrile concentration range from 20 to 30 % (solvent B) and a retention time of 20 to 50 min. In this study the optimal conditions for the analysis of nisin by RP-HPLC were determined: a gradient from 23 to 28 % acetonitrile (buffer B) when used as solvents: buffer A: [4 M LiClO4 – 0.1 M HClO4 ] : H2O=1:19; and buffer B: 100 % CH3CN with a retention time up to 12 min. Differences between the chromatographic profiles of expired and non-expired nisin samples have been identified. The expired nisin sample differs from the non-expired samples by the presence of asymmetric nisin A / Z peaks with significant degradation of the nisin A peak. The results of the study indicate the possibility using RP-HPLC for checking the quality and shelf life of commercial nisin samples without the need for additional purification
Kantō Daikasai: The Great Kantō Fire Following the 1923 Earthquake
Authors: Scawthorn Charles , Nishino Tomoaki , Schencking J. Charles , Borland Janet
Published: September 2023

The 1923 Great Kantō earthquake is one of the most deadly and destructive natural disasters in history. As the name connotes, fire is less considered in examinations of this event even though fire was responsible for the vast majority of death and destruction. Moreover, destruction of Tokyo by fire following an earthquake was foreseen and foretold as early as 1905, yet no actions were taken to reduce the risk. We therefore focus on fire aspects of the 1 September event with special attention to the capital Tokyo. Shaking intensities varied significantly across central Tokyo, with ∼100 ignitions distributed in all parts of the city occurring within the first hour. These rapidly grew into large fires due to the prevailing flammable wood-framed construction, high winds, and lack of firefighting water caused by breaks in water mains. However, even with adequate water, firefighters would likely still have been overwhelmed given the adverse meteorological conditions. The large fires soon merged into very large conflagrations that created their own localized high winds, further feeding the fires to the extent that fire whirls were created. The worst of these occurred in an area where many people were sheltering, causing 40,000 deaths. Even without this particularly tragic occurrence, the deaths due to fires were still greater than due to building collapse and other causes. Why the prescient warning issued years earlier went unheeded, what the social and political impact of the disaster and its aftermath was, and how fire and seismic risk reduction awareness influenced postdisaster reconstruction, are all questions we address. Although Japan since 1923 has implemented many measures to improve earthquake and postearthquake fire preparedness, the risk of fire following an earthquake remains significant in Japan as well as elsewhere.
Comment on “A New Decade in Seismoacoustics (2010–2022)” by Fransiska Dannemann Dugick, Clinton Koch, Elizabeth Berg, Stephen Arrowsmith, and Sarah Albert
Authors: Ringler Adam T. , Anthony Robert E. , Shiro Brian , Tanimoto Toshiro , Wilson David C.
Published: September 2023

An increase in seismic stations also having microbarographs has led to increased interest in the field of seismoacoustics. A review of the recent advances in this field can be found in Dannemann Dugick et al. (2023). The goal of this note is to draw the attention of the readers of Dannemann Dugick et al. (2023) to several additional interactions between the solid Earth and atmosphere that have not been classically considered in the field of seismoacoustics. The 15 January 2022 Hunga Tonga–Hunga Ha‘api eruption produced acoustic gravity waves that were recorded globally. For example, the Lamb wave from this eruption produced early-arriving and long-lasting tsunami waves. This eruption also provided globally recorded coupling of atmospheric modes with solid Earth modes, providing another example of the complex interactions that can occur at the boundary between the atmosphere and the solid Earth. Even in the absence of large atmospheric signals, collocated pressure sensors at seismic stations can be a useful tool for estimating the local substructure, such at VS30, the average shear velocity of the upper 30 m. Finally, at low frequencies, it is possible to use pressure records to correct out atmospheric disturbances recorded on seismometers. We briefly review the aforementioned, nontraditional seismoacoustic topics that we feel are important to consider as part of the full suite of interactions occurring between the solid Earth and atmosphere.
Understanding the Lived Experiences of Young Adults with Down Syndrome as Emerging Societal Members
Authors:   , Ahrens Nadjari Jamie , Sloand Janet
Published: September 2023

This phenomenological research study highlights the voiced needs and desires of individuals with Down syndrome, aged 21-30, experiencing the phenomenon of identifying as neurodiverse while living in a world designed for the neurotypical. The study provides a deeper understanding of lived experiences of individuals with Down syndrome as they enter societal roles after transitioning from secondary education. The findings shed light on the societal problem surrounding the lack of inclusion in higher education and the workforce as well as the lack of autonomy for individuals with cognitive disabilities under guardianship. The three outstanding questions embedded within this multi-site, phenomenological inquiry are: How do young adults with Down syndrome (age 21-30) understand and describe their lived experiences as emerging societal members? (a) How do young adults with Down syndrome (age 21-30) understand and describe the pathways available to them as emerging societal members? (b) How do young adults with Down syndrome (age 21 to 30) understand and describe the programs available to them as emerging societal members? and (c) How do young adults with Down syndrome (age 21 to 30) understand and describe their level of autonomy as emerging societal members? Understanding the social history associated with Down syndrome serves as the foundation of present societal practices and the experiences of these individuals. To explore these experiences and further support this research, the three streams of theory, research, and practice are as follows: Decision Making for Individuals with Disabilities, Secondary Education in Relation to Down Syndrome, and Present Pathways Available for Adults with Down Syndrome.
Condition of the Right Heart in Patients With COVID-19‑Associated Pneumonia: Follow-Up During Hospitalization
Authors: Poteshkina N. G. , Krylova N. S. , Karasev A. A. , Nikitina T. A. , Beloglazova I. P. , Kovalevskaya E. A. , Parshin V. V. , Lysenko M. A. , Ibragimova A. M. , Smorshchok V. N.
Published: September 2023

Aim      Dynamic assessment of the right heart in patients with COVID-19-associated pneumonia of different severity during regression of the systemic inflammatory response (SIR).

Material an methods    This single-center prospective study included 46 patients with the novel coronavirus infection COVID-19 and viral pneumonia according to chest multispiral computed tomography (CT). Laboratory and echocardiographic examinations of patients were performed.

Results Based on the results of evaluation with the Clinical Condition Scale (CCS-COVID), patients were divided into two groups: group A, patients with a score from 6 to 9 and group B, patients with a score from 10 to 14. The study results of both groups were evaluated twice: on day 10±2.5 from the onset of symptoms (groups A10 and B10, respectively) and again on day 17±1.8 (groups A17 and B17, respectively). Patients of group B10 had more pronounced SIR (C-reactive protein, 111.38±52.5 mg / l) and a larger volume of ground-glass opacity (38.3±9.6 %). At the first stage, higher values of right ventricular global longitudinal strain (RV GLS) were detected in group B10 compared to group A10 (23.2±4.8 % vs. 19.9±3.5 %, р=0.048). During the regression of SIR intensity and the positive dynamics of CT, lower values of Е / А were observed in group B17 (1.0 [0.98; 1.2]) vs. group А17 (1.4 [1.18; 1.5, p=0.015), and е’ / a’ in group B17 (0.66 [0.58; 0.85]) vs. 0.95 [0.79; 1.12] in group B17 (p=0.010). Е / А and е’ / a’ ratios were correlated with total lactate dehydrogenase fraction (r= –0.452 and p=0.006; r= –0.334 and p=0.050, respectively).

Conclusion      In patients with severe COVID-19-associated pneumonia during regression of SIR intensity, changes in the parameters that reflected RV diastolic dysfunction were observed.
Clinical and Morphological Features of Myocardial Infarction in Patients With a New Coronavirus Infection COVID-19
Authors: Zavyalova M. V. , Neklyudov A. A. , Zavyalov A. V. , Andryukhova E. S. , Paderov Yu. M. , Balakhonova M. V. , Krakhmal N. V. , Vtorushin S. V.
Published: September 2023

Aim      To analyze fatal outcomes of myocardial infarction (MI) in patients after COVID-19.

Material and methods  Data of pathoanatomical protocols and case histories of 612 patients managed in clinics of the Siberian State Medical University from 01.01.2020 through 31.12.2021 were studied. 68 (11%) of these patients were transferred to the clinics from respiratory hospitals for rehabilitation after the novel coronavirus infection. The main condition for hospitalization was a negative polymerase chain reaction (PCR) test for SARS-CoV-2 virus RNA. 544 (89%) of patients had no history of COVID-19. The incidence of MI was 14% (7/68) in patients after COVID-19 and 10% (74/544) in patients who have not had it. In pathoanatomical protocols and case histories of 81 patients diagnosed with MI, macroscopic and histological changes in the heart, pericardial cavity, coronary arteries, and laboratory results were evaluated. Statistical analysis was performed with a STATISTICA version 10.0 software package.

Results The patients after COVID-19 had a lower percentage stenosis, more frequent coronary artery thrombosis, and a positive D-dimer. According to our data, MI emerged 10.0 (2.0; 21.0) days after admission to the hospital, had a larger area, always was transmural, and rapidly resulted in death; the time of necrotic changes in all cases did not exceed 24 h. Upon admission to the hospital, the PCR test for SARS-CoV-2 virus RNA was negative, and acute inflammatory changes were stopped at the previous stage of hospitalization.

Conclusion      The risk of coronary thrombosis in patients after COVID-19 remains after the relief of acute inflammatory response and elimination of the infectious agent, thereby creating a risk of MI, that often leads to a fatal outcome.
The use of Dapagliflozin in Acute Decompensated Heart Failure: Results of the Randomized Study
Authors: Charaya K. V. , Schekochikhin D. Yu. , Nikiforova T. V. , Dimchishina A. S. , Soboleva T. V. , Shkliarov A. M. , Kusova Z. R. , Mesitskaya D. F. , Novikova N. A. , Andreev D. A.
Published: September 2023

Aim      To determine the effect of sodium-glucose cotransporter-2 inhibitors (SGLT2i) on kidney function in acute decompensated heart failure (ADHF).

Material and methods  A controlled randomized study on the dapagliflozin treatment in ADHF was performed. Patients were randomized to a main group (standard therapy supplemented with dapagliflozin) or a control group (standard therapy for ADHF). The primary endpoint was the development of acute kidney injury (AKI). 200 patients were included (mean age, 74±12 years; 51% men). 31% of patients had type 2 diabetes mellitus (DM2). Mean left ventricular ejection fraction (LV EF) was 47±14 %; in 44.5% of patients, LV EF was less than 45%. Median concentration of N-terminal pro-brain natriuretic peptide (NT-proBNP) was 5225 [3120; 9743] pg / ml, glomerular filtration rate (GFR) was 51 [38; 64] ml / min / 1.73 m2.

Results In-hospital mortality was 6.5%. Analysis of the dynamics of body weight loss showed significant differences (4200 [2925; 6300] g vs. 3000 [1113; 4850] g; p=0.011) in favor of the dapagliflozin group. The requirement for increasing the daily dose of furosemide and adding an another class diuretic (thiazide or acetazolamide) did not differ between the groups. However, median furosemide dose during the stay in the hospital was lower in the dapagliflozin group (80 [67; 120] mg vs. 102 [43; 120] mg; p=0.016). At 48 hours after randomization, GFR significantly decreased in the dapagliflozin group (–5.5 [–11; 3] ml/min/ 1.73 m2) compared to the control group (–0.3 [–4; 5] ml / min/1.73 m2, р=0.012). Despite this, GFR did not differ between the groups at discharge (51 [41; 66] ml/min/1.73 m2 and 49 [38; 67] ml/min/1.73 m2, respectively; p = 0.84). In the dapagliflozin group, frequency of AKI episodes was not increased compared to the control group (13 and 9.4%, respectively; p = 0.45).

Conclusion      The dapagliflozin treatment in ADHF is associated with more pronounced body weight loss and lower average doses of loop diuretics during the period of stay in the hospital, with no associated clinically significant impairment of renal function.
Formation of professional identity among university students (in English)
Authors: Власова И.В.
Published: September 2023

Исследуется вопрос о необходимости формирования профессиональной идентичности у студентов технических специальностей. Проведен анализ психолого-педагогической литературы по проблеме исследования. Делается вывод о том, что профессиональная идентичность является одним из основных компонентов самосознания и наиболее востребованным видом идентичности, ее формирование необходимо в процессе получения высшего профессионального образования и находится под влиянием психологических, социальных и педагогических факторов. Формулируются условия формирования профессиональной идентичности.

The question of the need to form a professional identity among students of technical specialties is being investigated. The analysis of psychological and pedagogical literature on the research problem was carried out. It is concluded that professional identity is one of the main components of self-consciousness and the most sought-after type of identity, its formation is necessary in the process of obtaining higher professional education and is influenced by psychological, social and pedagogical factors. The conditions for the formation of professional identity are formulated.
Some trends in the development of modern education (in English)
Authors: Беленкова Ю.С.
Published: September 2023

Раскрываются тенденции развития и актуальные проблемы современного образования в России. Подчеркивается важное значение онлайн образования и образовательных трендов, присущих цифровой эпохе. Рассматривается влияние цифровой экономики на развитие образовательного сектора. Описаны процессы распространения и применения цифровых технологий в современном образовании, которые помогают расширить возможности обучения. В контексте применения электронных средств обучения рассматривается семейное образование, актуальные методики, на которых может основываться процесс получения образования на дому. Делается вывод о том, что современные тенденции в образовании обладают огромным потенциалом и открывают новые возможности для совершенствования образовательной системы.

The development trends and topical problems of modern education in Russia are revealed. The importance of online education and educational trends inherent in the digital age is emphasized. The influence of the digital economy on the development of the educational sector is considered. The processes of distribution and application of digital technologies in modern education are described, which help to expand learning opportunities. In the context of the use of electronic learning tools, family education is considered, relevant methods on which the process of receiving education at home can be based. It is concluded that modern trends in education have great potential and open up new opportunities for improving the educational system.
Taking into account the specifics of the "practical" thinking of Chinese students in the process of teaching Russian as a foreign language
Authors: Гуань Б.
Published: September 2023

Обосновывается необходимость изучения психологических особенностей китайских обучающихся, занимающих сегодня первое место среди иностранных студентов в российских университетах, как контингента с отличительными особенностями. Описываются особенности китайского «практического» мышления, его значение в процессе обучения русскому языку как иностранному. По результатам исследования делается вывод об эффективности отобранных авторов методов обучения, корреспондирующих с «практическим» мышлением китайских студентов.

The necessity of studying the psychological characteristics of Chinese students, who today occupy the first place among foreign students in Russian universities, as a contingent with distinctive features, is substantiated. The features of Chinese “practical” thinking, its significance in the process of teaching Russian as a foreign language are described. Based on the results of the study, a conclusion is made about the effectiveness of the selected authors of teaching methods that correspond to the “practical” thinking of Chinese students.
The emergence and development of the classical system of artistic education in the history of pedagogy and education
Authors: Ал-Огаили А. Х.
Published: September 2023

Рассмотрена история художественного воспитания, выделены ее основные этапы (зарождение первобытного искусства, систематическое развитие идей о пользе обучения рисованию для общего развития индивида и др.). Выделяются особенности художественного воспитания в разные исторические периоды – Античность, эпоха Возрождения, Просвещения, Ренессанса, советский период. Делается вывод о важности изучения этапов развития системы художественного воспитания для лучшего понимания современных проблем и дальнейших перспектив ее развития.

The history of artistic education is considered, its main stages are highlighted (the origin of primitive art, the systematic development of ideas about the benefits of learning to draw for the overall development of the individual, etc.). The features of artistic education in different historical periods are highlighted – Antiquity, the Renaissance, the Enlightenment, the Renaissance, the Soviet period. The conclusion is made about the importance of studying the stages of development of the system of artistic education for a better understanding of modern problems and further prospects for its development.