bluuebunny/crossref_metadata_2025 huggingface dataset:
The continuous improvement system effectiveness monitoring methods
Authors:   Lukoil-Engineering Skills and Competencies LLC, Nizhny Novgorod, Russia, Usmanov M.R. , Grosul M.V. ,   Lukoil-Engineering Skills and Competencies LLC, Nizhny Novgorod, Russia, Firsov A.V. ,   Lukoil-Engineering Skills and Competencies LLC, Nizhny Novgorod, Russia
Published: February 2022

The purpose of the paper is to present methods for evaluation of the continuous improvement system (CIS) indicators within the organization during implementation, development and improvement. The approach proposed by the authors is aimed at measuring the effectiveness and sufficiency of activities during the CIS functioning. The material of the paper will be of interest to top managers, heads of HR services, specialists in the implementation of lean production tools, managers and specialists of business optimization departments, as well as to those who initiate and implement changes in the organization, who audit changes.
LUKOIL Group Oil Refining Facilities Production Activity Planning System Improvement
Authors:   Lukoil-Engineering Skills and Competencies LLC, Nizhny Novgorod, Russia, Ibulyev R. G.
Published: February 2022

The paper reviews the issue of the economic and mathematical method application, in particular, the planning systems based on linear programming in improving the efficiency of the enterprise management. The complexity of the task of optimizing the production program of oil refining and petrochemical companies, the solution of which requires taking into account many factors, is noted. A list of LP model improvements at LUKOIL Group refining facilities is provided. The promising trends of corporate linear programming tools implementation are described.
Machine learning as a tool for optimization of technological processes
Authors:   Lukoil-Engineering Skills and Competencies LLC, Nizhny Novgorod, Russia, Levchenko E. N.
Published: February 2022

The article discusses the problem of creating an optimization model of a technological process based on machine learning using the example of experience based on the H-Oil installation. The author showed the main approaches to such a model implementation, the architecture of the solution, and assessed the economic effect of such approaches.
Capital repair support
Authors:   Lukoil-Engineering Skills and Competencies LLC, Nizhny Novgorod, Russia, Sychev A. G. , Artemov A. I. ,   Lukoil-Engineering Skills and Competencies LLC, Nizhny Novgorod, Russia
Published: February 2022

The paper describes the methods of support for refinery turnarounds, using such management and control tools as a calendar activity scheduling and supervision of the repair process directly at the production site, noting the efficiency of the measures implemented and the results of the application of the acquired competencies for optimizing the process and improving the turnaround efficiency. Supervision means control over compliance with the correct fulfillment of the complete list of process operations during any types of repairing and construction work.
ПСИХОЛОГІЧНІ ОСОБЛИВОСТІ ПРОЯВІВ СТРЕСОСТІЙКОСТІ У ПІДПРИЄМЦІВ ТОРГОВЕЛЬНОЇ СФЕРИ
Authors: Авраменко М. В.
Published: February 2022

У статті представлено порівняльний аналіз особливостей проявів і рівня стресостійкості між групою підприємців з компенсованим стресом та із вираженим стресом за безпосередніми та опосередкованими показниками. В емпіричному дослідженні використано методики, що спрямовані на визначення кількісних характеристик професійного стресу, – «Тест на стресостійкість», «Тест самооцінки стресостійкості» (С. Коухена і Г. Віліансона) – та якісних показників його проявів – «Комплексна оцінка проявів стресу» і «Вегетативні прояви стресу» (Ю. Щербатих). Особистісні характеристики визначались за методикою «16-факторний особистісний опитувальник Кеттелла» з визначенням емоційно-вольової, комунікативної та інтелектуальної сфер досліджуваних. Встановлено, що високий рівень стресостійкості у групі з компенсованим стресом зумовлений гармонійним поєднанням функціонування емоційних, поведінкових, інтелектуальних та фізіологічних показників. При цьому доведено, що для представників групи з компенсованим стресом притаманний такий високий рівень індивідуально-психологічних характеристик, як емоційна стійкість, комунікативні здібності та показники інтелекту. Водночас за порівняльним аналізом показників групи компенсованого і вираженого стресу виявлено, що у осіб з вираженим стресом спостерігається високий рівень проявів професійного стресу, емоційних, інтелектуальних і фізіологічних симптомів, що поряд з високим рівнем чутливості обстежуваних до стресогенних факторів зумовило високий показник комплексної оцінки проявів стресу. При цьому виявлено низький рівень таких індивідуально-психологічних особливостей, як емоційна стійкість, комунікативні здібності, що загалом зумовлює низький рівень стійкості до стресу у осіб з вираженими проявами стресу та вказує на необхідність психологічної корекції.
ВЗАЄМОЗВ’ЯЗОК ТИПІВ СПРИЙНЯТТЯ СТИЛІВ МИСТЕЦТВА ТА АГРЕСІЇ
Authors: Martyniuk Yu. O.
Published: February 2022

Метою статті є дослідження особливостей взаємозв’язку агресивної поведінки та особливостей сприйняття художнього стилю мистецтва. Згідно з нашою гіпотезою люди з переважанням певної агресивної поведінки налаштовуються на певні моделі поведінкових реакцій, зображені у витворах мистецтва. Для нашого дослідження використано теоретичні (індукція, абстракція, узагальнення, систематизація) та емпіричні (метод психологічної діагностики та методи математичної обробки даних (описова статистика, кореляційний аналіз)) методи. Методика психологічної діагностики містила: авторську анкету «Художні уподобання», метод діагностики форм агресії А. Басса та Д. Арка, метод-тест «Руки» Е. Вагнера. У результаті дослідження виявлено, що існує взаємозв’язок між ренесансним типом сприйняття художнього стилю та непрямою агресією, а також залежність, яка пригнічує агресивні тенденції в поведінці. Слід зазначити, що виявлено зв’язок барокового типу сприйняття художнього стилю мистецтва з роздратуванням та афектацією. З’ясувалося, що існує взаємозв’язок між класичним типом сприйняття художнього стилю мистецтва та фізичною агресією, а також директивністю. Імпресіоністичний тип сприйняття художнього стилю мистецтва корелює з вербальною агресією та ексгібіціонізмом у вияві агресії. Зазначимо, що існує пряма кореляція між сюрреалістичним типом сприйняття художнього стилю мистецтва та підозрілістю та зворотна – із залежністю. Отримані дані вказують на те, що існує пряма кореляція між абстрактним типом сприйняття художнього стилю мистецтва та негативізмом, але, з іншого боку, виявлено зворотну кореляцію зі схильністю до агресивної поведінки загалом.
РОЛЬ ЖИТТЄВОГО СЦЕНАРІЮ У РОЗВИТКУ АВТОБІОГРАФІЧНОЇ ПАМ’ЯТІ
Authors: Бурлачук Л. Ф. , Лисенко І. П. , Діденко С. В.
Published: February 2022

У статті розкрито сутність поняття «автобіографічна пам’ять» (АП) як специфічної мнемічної системи, яка значним чином відрізняється у людей різного віку та статі залежно від індивідуального життєвого досвіду та «життєвих сценаріїв». АП визначається як власне уявлення про загальні або особливі події та факти, пройдений відрізок життєвого шляху. Дослідження АП дозволяють виявити структурні та функціональні закономірності, що не властиві іншим видам пам’яті, та отримати нові для психологічної науки фундаментальні знання, які сприяють відповіді на питання про універсальність тих законів роботи пам’яті, які дотепер вважалися загальними для всіх мнемічних процесів особистості, пов’язаних з подіями життя. Поняття «культурний життєвий сценарій» дає змогу зрозуміти, що сценарність особистого минулого посилюється в процесі онтогенетичного розвитку і соціалізації дитини. Проте більшість значущих подій, про які згадує доросла людина, представляючи історію свого життя, входять у зміст типового життєвого сценарію. Проблема вивчення АП перебуває на стику дослідження особистості і пам’яті та дозволяє знайти нові ракурси їх вивчення. АП є базисом самосвідомості особистості, а її закономірності пов’язані не тільки з мотиваційно-смисловими, емоційними процесами та когнітивними процесами, а і з життєвими сценаріями. Проведений аналіз довів, що АП має специфічні, властиві тільки цьому виду пам’яті функції і закономірності, суб’єктивне відображення пройденого людиною відрізка життєвого шляху, актуалізацію автобіографічних значущих подій і станів, якими визначається самоідентичність особистості. У статті розглянуті види життєвих сценаріїв та наданий аналіз їх ролі у розвитку автобіографічної пам’яті у жінок та чоловіків різного віку, вікових та статевих відмінностей вивчення особливостей АП.
Pre-Service Teachers’ Career Choice Motives: A Scale Development Study
Authors: Erben-Kecici Sayime , Aydin Mustafa
Published: February 2022

In the present study, it is aimed to develop a valid and reliable scale to examine the factors playing role in the career choices of pre-service teachers studying in different teacher education programs. Accordingly, the scale was developed with the data gathered from 360 pre-service teachers studying in different departments of the education faculty of a state university in the Central Anatolian Region in Turkey in the 2018-2019 academic year. Only freshmen students were included in the sample and thereby their motives for choosing teaching profession were examined in the time period when they had just started teacher education programs. The scale development process started with the generation of the item pool based on a literature review and studies of validity and reliability followed this phase. Specialists’ opinions were resorted to for content validity and the construct validity was tested through exploratory factor analysis. Cronbach’s Alpha values were examined for reliability. As a result of the validity and reliability studies, it is put forth that the 26-item scale consisted of five factors which are advantages of profession, pedagogic interest, belief in talent, social effects and lesser difficulty level of teaching programs. The validity and reliability values of the scale suggest that it is a valid and reliable instrument to be used in studies related to pre-service teachers’ motives in career choices.
Exploring the Link between Foreign Language Anxiety and Attitudes towards English among Turkish High School EFL Learners
Authors: Özer Zekiye , Yetkin Ramazan
Published: February 2022

The current study was conducted to investigate the relationship between foreign language anxiety (FLA) and attitudes towards English. A total 518 Turkish students studying at private and state high schools participated in the study.  Quantitative research design was adopted in the present study. Foreign Language Classroom Anxiety Scale (FLCAS) and Attitudes towards English Scale were used as data collection tools. In order to analyze data, SPSS 23 software was used, and Multivariate Analysis of Variance (MANOVA) and correlation statistics were utilized. According to data analysis results, the study revealed that students’ FLA levels were at moderate level and they had negative attitudes towards English. The results of data analysis also indicated that there was a negative strong relationship between students’ FLA levels and their attitudes towards English. Although gender had a significant impact on students’ anxiety levels, grade levels of students were not seen as a factor strongly related to FLA. It was also found that ninth and tenth graders had more positive attitudes towards English classes. However, gender was not a predictive factor for students’ attitudes towards English. These results suggest that positive attitudes help students to overcome FLA. That is why, fostering positive and enjoyable language learning environment is significant to increase success in English.
Analysis of Covid 19 Data in Indonesia Using Supervised Emerging Patterns
Authors: Rahardja Untung , Dewanto Ignatius Joko , Djajadi Arko , Candra Ariya Panndhitthana , Hardini Marviola
Published: February 2022

This research method uses CRISP-DM with emerging pattern supervision modeling and EPM Algorithm. The contribution of the research is to assist the Government in overcoming the problem of the spread of the COVID-19 cluster in several regions in Indonesia. The research aims to implement information on the COVID-19 data mining pattern in the DKI Jakarta area. The problems faced are the difficulty of identifying the pattern of COVID-19 data in one area, it is difficult to dig up data on the http://corona.jakarta.go.id website. It is not easy to decide on the handling of COVID-19. The output of the research results in a cluster of information on COVID-19 in the DKI Jakarta area based on Significance level depends on the Covid Map In terms of Region, Status, Gender, & age And Signification can be the basis for determining covid OTG, DTG, and Positive. The theoretical and practical implications can be stated as follows: The use of supervised emerging pattern methods can affect the processing of COVID-19 data. For 5 Regions in DKI Jakarta and distribution to determine covid OTG, DTG, and Positive. The result of the development of this data mining system is to produce pattern reports to produce Supervised Emerging Patterns technology for decision making at the COVID-19 Task Force in DKI Jakarta.
Influence of Consumer Behavior and Marketing Mix on Product Purchasing Decisions
Authors: Dewi Faye Maya , Sulivyo Lod , Listiawati
Published: February 2022

The purpose of the study was: 1) to look at the direct influence between consumer behaviour on the marketing mix, 2) to look at the direct relationship between consumer behaviour on purchasing decisions, 3) to look at the influence of direct relationships between marketing mixes on purchasing decisions, 4) to look at the indirect influence of indirect relationships between consumer behaviour toward purchasing decisions mediated by the marketing mix. The sample used in the study was as many as 120 randomly selected respondents, and data processing using Smart PLS 2.0 software. The results of this study are, 1) consumer behaviour towards the marketing mix has a positive and significant influence with a relationship value of 55,899 > 1.96. 2) Consumer behaviour towards purchasing decisions has a positive and significant influence with a relationship value of 2,850 > 1.96. 3) Marketing mix on purchasing decisions has a positive and significant influence value with a relationship value of 13,764 > 1.96. 4) The results of analysis of indirect influence pathways between consumer behaviour to purchasing decisions mediated by marketing mix is 13,554 > 1.96 with a significance level of 5% proving that marketing mix has a significant effect in mediating the relationship between consumer behaviour to purchasing decisions.
Human Resource Competence And Innovation Of Small And Medium Micro Enterprises (UMKM) Tangerang Regency
Authors: Suhara Toni , Husin  , Bangun Cicilia Sriliasta
Published: February 2022

This research looks at the influence of human resource competence and innovation on small and medium-sized micro-enterprises. The study uses a quantitative approach by testing hypotheses using statistics. Calculations are done based on statistical formulas with the help of the Smart PLS 2.0M3 application. The study uses a survey method, i.e., collects data from specific natural locations, but the researchers implement treatments in data collection by distributing tables, questions, structured tests, and interviews. The sample for the study was 65 respondents. The results of this study are: (1) The influence of market orientation on human resource competence has a positive and significant value. It is seen from the relationship between variables of 63,534 > 1.96. (2) There is a positive and significant influence between market orientation towards MSME innovation, it is seen from the relationship between variables 4,145 > 1.96. (3) There is a positive and significant influence between human resource competencies on MSME innovation. This is evident from the relationship results between variables 15,149 > 1.96. (4) There is a positive and significant influence between market orientation and human resource competence on MSME innovation. This is seen from the relationship results between variables of 78,683 > 1.96.
Decision-Making Techniques using LSTM on Antam Mining Shares before and during the COVID-19 Pandemic in Indonesia
Authors: Badri Ahmad Kamal , Heikal Jerry , Terah Yochebed Anggraini , Nurjaman Deden Roni
Published: February 2022

Stocks, apart from having volatile and chaotic characteristics, also have various kinds of noise, non-linear and non-stationary movements, making them difficult to predict accurately. Therefore, the risk of investing in stocks depends on the skills of investors or traders in making judgments and decisions. This study aims to use Long Short-Term Memory (LSTM) as a decision-making technique with historical stock prices as the sole predictor, then implement it in conditions before and during the COVID-19 pandemic. The study results concluded that Long Short-Term Memory (LSTM) could be used as a decision-making technique in conditions before and during the COVID-19 pandemic with historical price inputs as the sole predictor. Based on the research that has been done, the following conclusions can be drawn: The LSTM model can predict stock prices well using historical stock prices as the sole predictor. The LSTM model can be used as a trading decision-making technique for day traders. The risk of stock prediction using the LSTM method in 2019 before the COVID pandemic was proven to be lower than in 2020 during the COVID pandemic. For further research, researchers can conduct more in-depth research on the risk criteria for making trading decisions as an essential reference that can be used to select the LSTM model.
Analysis of the Effect of Service Quality on Company Reputation on Purchase Decisions for Professional Recruitment Services
Authors: Fernando  , Bintoro B. P. Kusumo , Lutfiani Ninda , Haryanto  , Julianingsih Dwi
Published: February 2022

This study aims to analyze the effect of company reputation and service quality on purchasing decisions for headhunter services. This study is to determine the basis for consumer considerations in choosing a headhunter company, and for headhunter companies this research can be a reference in maintaining relationships with their customers. There are 3 hypotheses tested, and this study uses quantitative methods by conducting surveys. The sampling method is using probability sampling with a sample size of 115 respondents based on the hair formula. As for analyzing the data of this study using multiple linear regression analysis methods.The company's reputation and service quality both influence the decision to purchase headhunter services, with the main factor having higher relevance being the service quality variable. This study aims to determine the relationship of company reputation and service quality to purchasing decisions on professional recruitment services. Future research is expected to raise one case from a large headhunter company (local/international) regarding building the reputation of a headhunter service company. This is so that the headhunter Industry has a proven academic subject of what reputation looks like in the Headhunter Industry
Factors That Influence The Intention of The Millennial Community to do Waqf With a Modification of Theory Planned Behavior Approach
Authors: Zawawi Abdullah Achmad , Mariyanti Tatik , Sari Siti Nurindah
Published: February 2022

This research aims to analyze the influence of variables knowledge, attitudes, religious commitment, subjective norm, and the use of ICT Technology significantly influence behavior through the intention of the millennial generation in waqf in Jabodetabek. The methodology used in this study is the Structural Equation Model with the variables of knowledge, attitudes, religious commitment, subjective norms, and ICT technology as independent variables; intention as moderating variable, and waqf behavior as the dependent variable. The primary data of this study was obtained through a questionnaire survey to 290 respondents obtained through purposive random sampling from the millennial generation aged 21-40 years who live in Greater Jakarta. Then the data was analyzed using SPSS and AMOS software. Based on the results of this study, it was learned that the variable of knowledge does not affect the behavior of waqf through the intention of the millennial generation. In contrast, the variables of attitude, commitment, subjective norms, and the use of ICT technology had a positive and significant effect on waqf behavior through the intention of the millennial generation. This shows that the millennial generation, although their knowledge does not affect behavior, attitudes, commitment, subjective norms, and the use of ICT technology, have a positive and significant effect on waqf behavior results of this study indicate that the variables attitudes, religious commitment, subjective norm, and the use of ICT Technology significantly influence behavior through the intention of the millennial generation in waqf in Jabodetabek. At the same time, knowledge does not affect that behavior. This study implies that measuring consumer behavior should be equipped with additional indicators, namely intention, to analyze the behavior based on external factors and spiritual and social aspects.
AI and Nanotechnology for Healthcare: A survey
Authors: Rawat Bhupesh , Bist Ankur Singh , Supriyanti Dedeh , Elmanda Vonda , Sari Siti Nurindah
Published: February 2022

AI is today's wave of technology, and it caters to various problems. One of them is Nanotechnology. Nanotechnology is another thread of technology. The use of nanotechnology is well known, including in the health sector, cosmetic industry, and agriculture. The role of AI in healthcare is broad, from detecting lung disease to skin analysis. This study aims to explore healthcare possibilities by integrating AI and nanotechnology. The method of applying nanotechnology in the health sector uses a Nanomedicine Microscope. Nanomedicine is the medical application of nanotechnology used to diagnose, monitor, and control biological systems. Therefore, the author uses the Nanomedicine Microscope as the object in this study because the wonders of nanotechnology in various operations are also well established. The novelty in this paper focuses on AI and Nanotechnology together as possibilities for healthcare. AI and nanotechnology are two critical technologies. The ultimate goal is to integrate the uses and possibilities of these two technologies and do wonders in the healthcare domain. This study will benefit those working in AI and medicine. Nanotechnology integrating AI technology into the medical industry enables many conveniences, including task automation and analyzing large amounts of patient data for better, faster, and more affordable healthcare.
Determinant of Interest in Paying Zakat with Age as a Moderating Variable (Study on Minang Society)
Authors: Harmaini  , Basri Yuswar Zainul , Arafah Willy
Published: February 2022

This study wants to test whether there is an influence between Zakat Knowledge, Religiosity, Culture, Subjective Norms, and Income on Muzaki Minang's zakat interest in paying zakat, with age as a moderating variable. The purpose of this study will be to analyze and describe the effect of Muzaki Minang's interest in tithing by using a theoretical model. The data collection technique used a questionnaire and sampling was done by purposive sampling with a total of 320 respondents. The population in this study is the Muzaki Minang population who live in West Sumatra and outside West Sumatra. The data analysis technique used is descriptive statistical analysis. The results of this study are the knowledge of zakat and culture variables do not affect Muzaki's interest in zakat. While the interest in paying zakat which has a significant and positive effect is religiosity, subjective norms, and income. There is a moderate relationship between income and age with interest in paying zakat. The dominant age factor is early adulthood (20-40 years) compared to old age (>40 years). The findings of this study are helpful input for the leaders of the indigenous people of West Sumatra in strengthening the understanding of the younger generation about Minang customs. With the increasing understanding of adat for the Minang community, they are interested in paying zakat themselves and using zakat as a tool to improve people's welfare.
AI Based Drones for Security Concerns in Smart Cities
Authors: Rawat Bhupesh , Bist Ankur Singh , Apriani Desy , Permadi Nur Ihsan , Nabila Efa Ayu
Published: February 2022

The concept of a smart city has attracted the attention of all corners of the world. It updated with new technologies like AI, Blockchain, IoT, Drones, and many other things. Security in big cities is one of the main concerns, and everyone wants to feel safe 24/7 in every activity they do. In this paper, our research aims to highlight the use and importance of drones for intelligent city management, especially in the context of security. The drone security management flow is explained using the methods and technical details. This is followed by discussion on security concern in cities and how it is dealt with AI based drones.  In the conclusion section, it is discussed how emerging technology such as blockchain can help improve the management of smart cities. The use of drones supports the intelligent city concept with all its advantages in regional monitoring. Concept of smart cities is catching attention across the globe and it’s important as per context of emerging economies. In this paper, we discussed about the use of emerging technologies to make it possible. AI, Blockchain and Drone technologies are playing important role. Their significance and attention by researchers in exploring possibilities is shown in this paper. This paper will be very useful for researchers and engineers working in the same domain.
Analisis Teori Pemasaran Pada Perilaku Konsumen Terhadap Kualitas Manajemen Pelayanan Jasa PT. Bank Rakyat Indonesia
Authors: Warseno Warseno , Rafika Ageng Setiani , Firdaus Yusuf
Published: February 2022

Pada dasarnya eksistensi Bank di Indonesia saat ini sangat diperlukan karena kehadirannya kini sudah menjadi sebuah kebutuhan dan menjadi tempat ketergantungan bagi setiap warga negara yang ingin memiliki simpanan uang serta menabung untuk menjaga keuangan masa depannya. Selain itu, posisi Bank dulunya dapat digambarkan sebagai cara modernisasi untuk keluar masuknya uang yang lebih baik, aman, dan terjaga. Karena, jika ditinjau dengan cara terdahulunya orang-orang menabung menggunakan celengan secara konvensional atau disimpan pada tempat tertentu yang dianggap aman namun tidak menjanjikan karena kualitas uang perlu dijaga agar tetap dapat dipergunakan dalam bertransaksi jual-beli barang baik secara online maupun secara konvensional (secara langsung). Maka dari itu, atas pemaparan hal tersebut kini era serba modernisasi ini telah banyak perusahaan Bank yang tersebar dan berkembang hal ini dikarenakan banyaknya nilai-nilai kesadaran yang dimiliki oleh setiap individu baik sebagai konsumen maupun nasabah yang nantinya memanfaatkan jasa pelayanan dalam perusahaan Bank tersebut. Dalam hal ini, penulis akan menetapkan parameter yang berfokus pada perusahaan Bank Rakyat Indonesia yang merupakan salah satu Bank yang statusnya milik lembaga pemerintah yang cukup besar di Indonesia dan dalam hal penulisan ini akan berfokus pada manajemen branding dari lembaga Bank BRI tersebut.
The Influence of Financial Performance Dimensions on Local Government Capital Expenditure Allocation
Authors: Hasanuddin Rusdiah , Elpisah E. , Muslim M.
Published: February 2022

The purpose of this research is to analyze and to know the effect of degrees of decentralization, financial dependency, financial independence, effectiveness of PAD and the degree of contribution of BUMD to the allocation of capital expenditures of Gowa Regency. This research uses explanative research, which aims to test and obtain empirical evidence of the direct effect of financial performance on the allocation of regional government capital expenditures of Gowa Regency in 2002 until 2016. The data source used is secondary data using multiple linear regression method that is the method of analysis for more than one independent variable. Based on the test results found that the degree of decentralization and financial dependence have a negative and insignificant effect on the allocation of capital expenditure, financial independence has a positive and not significant effect on the allocation of capital expenditure while the effectiveness of PAD and the contribution of BUMD have positive and significant influence on the allocation of capital expenditure. Among the five independent variables, the most dominant effectiveness of PAD (X4) has an influence in the allocation of capital expenditure of the Gowa Regency Government compared to other variables.
Increased visceral fat distribution and body composition impact cytokine release syndrome onset and severity after CD19 chimeric antigen receptor T-cell therapy in advanced B-cell malignancies
Authors: Dos Santos David M. Cordas , Rejeski Kai , Winkelmann Michael , Liu Lian , Trinkner Paul , Günther Sophie , Bücklein Veit L. , Blumenberg Viktoria , Schmidt Christian , Kunz Wolfgang G. , Von Bergwelt-Baildon Michael , Theurich Sebastian , Subklewe Marion
Published: February 2022

Chimeric antigen receptor T-cell (CAR-T) therapy is associated with a distinct toxicity profile that includes cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). CRS is characterized by the release of pro-inflammatory cytokines such as interleukin 6 (IL-6) and is closely linked to CAR-T expansion and bystander cells like monocytes/macrophages. In other hyperinflammatory states, obesity contributes to inflammatory cascades and acts as a risk factor for disease severity. We aimed to study the influence of anthropometric and body composition (BC) measurements on CAR-T-related immunotoxicity in 64 patients receiving CD19-directed CAR-T for relapsed/refractory Bcell malignancies. Patients with grade ≥2 CRS presented with a significantly higher median body mass index (BMI), waist circumference, waist-to-height ratio (WtHR) and visceral adipose tissue (VAT). These parameters were also found to be associated with an earlier CRS onset. Other adipose deposits and muscle mass did not differ between patients with grade 0-1 CRS versus grade ≥2 CRS. Moreover, BC parameters did not influence ICANS severity or onset. In a multivariate binary logistic regression incorporating known risk factors of immunotoxicity, the factors BMI, waist circumference, WtHR and VAT increased the probability of grade ≥2 CRS. Receiver operating characteristic analyses were utilized to determine optimal discriminatory thresholds for these parameters. Patients above these thresholds displayed markedly increased peak IL-6 levels. Our data imply that increased body composition and VAT in particular represent an additional risk factor for severe and early CRS. These findings carry implications for risk-stratification prior to CD19 CAR-T and may be integrated into established risk models.
Annemarie von Gabain 1901–1993
Authors: Laut Jens Peter
Published: February 2022

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Efektivitas Komite dan Mekanisme Tata Kelola Perusahaan terhadap Pencegahan Kejahatan Keuangan
Authors: Alice Alice , Christian Natalis
Published: February 2022

Abstract
The research objectives of this study are to analyze the effectiveness of committee and mechanism of corporate governance to prevent financial crime. Financial Crime often occur inside the company, especially in Indonesia. Financial crime covers fraud, money laundering, bribe, corruption, terrorist financing and so on. At 2018, there’s case where PT. Garuda Indonesia committed revenue recognition fraud by recognizing revenue amounted to USD 239 million from Mahata Aero Teknologi which is yet to be received by the end of 2018. The company’s management and external audit are fined for the negligent in preventing the fraud. Therefore, the effectiveness of company’s organizational structure played a big role to supervise and prevent the occurrence of financial crimes. In this discussion, the author investigates the effectiveness of audit committee, board of commissioners, stand-alone risk committee, external audit, effect of managerial ownership and company’s performance toward financial crime. Data for the research were collected from secondary data found in annual report of 426 companies and analyzed using logistic regression method using SPSS 25. The study findings prove that stand-alone risk committee, external audit, and company’s performance have a significant negative effect toward financial crime, while size of audit committee have a significant positive effect toward financial crime. Research show that meeting frequency of audit committee, board of commissioners, and managerial ownership has no significant effect toward financial crime
COVID-19 SALGINI İNANÇ İLİŞKİSİ
Authors: BULUT İsmail , KOÇ Ahmet
Published: February 2022

Bu çalışma, 2020 yılında bütün dünyayı etkisi altına alan ve hâlâ devam etmekte olan COVID-19 salgını ile dinî inanç arasındaki ilişkiyi tespit etmeyi amaçlamaktadır. Bu kapsamda Hitit Üniversitesi’nde öğrenim gören öğrencilerin COVID-19 salgınını ve bundan kaynaklı tıbbi, psikolojik, sosyal vb. durumları inanç açısından nasıl değerlendirdiklerini ve inancın hastalık üzerindeki etkisini tespit etmek amacıyla 344 öğrenciye anket uygulanmıştır. Katılımcıların vermiş olduğu cevaplar analiz edildiğinde salgının açıklanma biçiminin nedensellik ilkesi çerçevesinde, bireylerin sosyal, kültürel ve ekonomik durumları doğrultusunda heterojenlik gösterdiği saptanmıştır. İnsan-din ilişkisinde salgın ve doğal afetler gibi olağanüstü durumların etkisinin kaçınılmaz olduğu görüşü dile getirilmiştir. Dinî bağlamda açıklamalar, nedensellik ilkesini destekler niteliktedir. Dinsel söylem, insan sağlığı ve dünya odaklı yaşam sürmeye karşılık salgın gibi felaketlerin ibret, ceza ve hikmet bağlamında değerlendirilebileceğini öne sürmektedir. Elde edilen bilgiler ışığında katılımcıların, -virüsün insanlar tarafından laboratuvar ortamında üretildiğini düşünseler dahi- değişmez ve yazılı bir kader anlayışına sahip oldukları, virüsün Allah'tan gelen bir imtihan olduğu düşüncesini taşıdıkları görülmüştür. Katılımcıların salgın karşısında geliştirdikleri tutumlar üzerinde yetiştikleri kültürün ve çevrelerinden edindikleri dinî inancın ve aldıkları dinî eğitimin önemli rol oynadığı, aynı zamanda bireyin dinî yaşantısının, eğitim düzeyinin ve yaşadığı çevrenin olaylara bakış açısını etkilediği görülmüştür.
RNA interference as a novel treatment strategy for chronic hepatitis B infection
Authors: Hui Rex Wan-Hin , Mak Lung-Yi , Seto Wai-Kay , Yuen Man-Fung
Published: February 2022

Chronic hepatitis B (CHB) is a major cause of liver-related morbidity and mortality. Functional cure of CHB, defined as sustainable hepatitis B surface antigen (HBsAg) seroclearance, is associated with improved clinical outcomes. However, functional cure is rarely attainable by current treatment modalities. RNA interference (RNAi) by small-interfering RNA (siRNA) and anti-sense oligonucleotide (ASO) has been studied as a novel treatment strategy for CHB. RNAi targets post-transcriptional messenger RNAs and pregenomic RNAs to reduce hepatitis B virus (HBV) antigen production and viral replication. By reducing viral antigens, host immune reconstitution against HBV may also be attained. Phase I/II trials on siRNAs have demonstrated them to be safe and well-tolerated. siRNA is effective when given in monthly doses with different total number of doses according to different trial design, and can lead to sustainable dose-dependent mean HBsAg reduction by 2–2.5 log. Incidences of HBsAg seroclearance after siRNA therapy have also been reported. ASOs have also been studied in early phase trials, and a phase Ib study using frequent dosing regimen within 4 weeks could achieve similar HBsAg reduction of 2 log from baseline. Given the established efficacy and safety of nucleos(t) ide analogues (NAs), future RNAi regimens will likely include NA backbone. While the current evidence on RNAi appears promising, it remains undetermined whether the potent HBsAg reduction by RNAi can result in a high rate of HBsAg seroclearance with durability. Data on RNAi from phase IIb/III trials are keenly anticipated.
Opis grobów i zabytków / Description of graves and artefacts
Authors: Tomczak Eugeniusz , Szczepanek Anita , Jarosz Paweł
Published: February 2022

Detailed description of 71 graves and their furnishings.
Paleodieta osób pochowanych w grobach szkieletowych z późnej epoki brązu – wybrane przykłady / Paleodiet of individuals buried in inhumation graves at the Late Bronze Age cemetery – selected cases
Authors: Szczepanek Anita , Jarosz Paweł
Published: February 2022

For the analysis of stable carbon and nitrogen isotopes, three samples were taken: two from human bones and one from an animal bone. The values of δ13C measured in human remains were similar and range from -14.3‰ to -14‰, and δ15N from 7.8‰ to 8.1‰. For animal bones, these values were much lower, with δ13C at -20.9‰, and δ15N at 5.8‰. The obtained data clearly indicate a significant share of millet (C4 plant) in the diet of the people buried at the cemetery in Gogolin. For the Lusatian culture communities, the consumption of millet has been determined in isotopic studies of other necropolies, such as Kraków-Wyciąże, site 5, but δ13C values obtained for individuals buried there were lower and ranged from -17.8‰ to -17.6‰. The presence of millet in the materials of the Lusatian culture has also been directly confirmed by preserved plant remains and grain imprints on clay vessels. The fact that the δ15N values acquired for humans were only slightly higher than the value obtained for the analysed cattle bone proves that the diet of the Gogolin population was based mainly on plant products and was supplemented with animal protein only to a small degree. Such a composition of the consumed food is typical of a settled population with a dominance of land cultivation in subsistent strategy, and at the same time reflects the type of economy postulated for the Lusatian culture communities. Consequently, the diet of the individuals buried at the cemetery in Gogolin clearly differs from the diet of a mobile, pastoral community.
PENINGKATAN KETERAMPILAN BERBAHASA INDONESIA SISWA MELALUI VOICE NOTE SEBAGAI MEDIA DISKUSI
Authors: Nurani Dwi Cahaya , Rahardjo Agung Supardjo Budi , Adikara Fahmi Surya
Published: February 2022

Tujuan penelitian ini adalah untuk meningkatkan keterampilan Berbahasa Indonesia siswa melalui penggunaan voice note  pada platform Whatsapp sebagai media diskusi pada siswa kelas III SD Negeri Proyonanggan 01 tahun ajaran 2020/2021. Bentuk penelitian ini adalah penelitian tindakan kelas (PTK). Teknik pengumpulan data adalah observasi, wawancara, tes, dan dokumen. Validitas data adalah triangulasi sumber dan triangulasi teknik, serta validitas isi. Teknis analisis data adalah analisis interaktif, teknik deskriptif komparatif, dan teknik analisis kritis. Berdasarkan hasil penelitian dapat disimpulkan bahwa penggunaan voice note pada platform Whatsapp dapat meningkatkan keterampilan Berbahasa Indonesia Siswa. Peningkatan keterampilan Berbahasa Indonesia siswa tersebut dapat dibuktikan dengan meningkatnya nilai keterampilan Berbahasa Indonesia pada setiap siklus, yaitu nilai rata-rata keterampilan Berbahasa Indonesia siswa pada pratindakan hanya sebesar 69,8. Setekah mendapatkan tindakan di siklus I rata-rata kelas menjadi dan meningkat lagi pada siklus II menjadi 85,1. Pada siklus II siswa yang mencapai KKM sebanyak 30 siswa (90,90%) dari jumlah siswa seluruhnya. Hal ini membuktikan bahwa indikator kinerja penelitian, yaitu ketercapaian KKM ≥75 sebanyak 80% telah terpenuhi. Berdasarkan hal tersebut, dapat disimpulkan bahwa penggunaan  voice note  pada platform Whatsapp sebagai media diskusi dapat meningkatkan Keterampilan Berbahasa Indonesia siswa kelas III SD Negeri Proyonanggan 01 tahun ajaran 2020/2021.
Effects of Blended Poly(3-hexylthiophene) and 6,13-bis(triisopropylsilylethynyl) pentacene Organic Semiconductors on the Photoresponse Characteristics of Thin-Film Transistors
Authors: Shin Hyunji , Lee Hyeonju , Kim Bokyung , Zhang Xue , Bae Jin-Hyuk , Park Jaehoon
Published: February 2022

In this study, we demonstrate high-performance optical wavelength-selective organic thin-film transistors (TFTs) that incorporate heterogeneous organic semiconductor materials, poly(3-hexylthiophene) (P3HT) and 6,13-bis(triisopropylsilylethynyl) pentacene (TIPS-pentacene). The electrical characteristics of the fabricated transistors were analyzed in the dark to determine how the P3HT:TIPS-pentacene ratio of the semiconductor affected the performance of the transistor. Specifically, the P3HT:TIPS-pentacene weight ratio was varied (1:0, 1:0.25, 1:0.5, 1:0.75, 1:1, and 0:1) by blending 1 wt% P3HT dissolved in chloroform, and 1 wt% TIPS-pentacene dissolved in anisole. The UV-visible light absorbance characteristics of the films containing the P3HT, TIPS-pentacene, and P3HT:TIPS-pentacene blends were analyzed. Monochromatic light at wavelengths of 515 and 450 nm was used to clarify the influence of irradiation on the electrical characteristics of the TFTs. The results confirmed that the TFT containing P3HT:TIPS-pentacene at a blending ratio of 1:0.5 had the largest light-to-dark current ratio, i.e., approximately 33.8 and 23.5 when exposed to monochromatic light at wavelengths of 515 nm and 450 nm, respectively. The TFT with the P3HT:TIPS-pentacene blending ratio of 1:0.5 exhibited the highest photosensitivity values of 261.9 and 49.6 upon irradiation with light at wavelengths of 515 nm and 450 nm, respectively. The observed improvement in the performance of the heterogeneously blended organic transistors is discussed in relation to the morphological structure and charge transport path of the P3HT:TIPS-pentacene blended semiconductor films.
Effect of Inorganic Additives and Sintering Temperature on Adsorbents
Authors: Bae Min A , Kim Kyeong Ho , Baek Jae Ho
Published: February 2022

Magnesium silicate is a porous material with a large specific surface area and is easily adsorbed. In particular, it is widely used commercially because it is very effective for adsorbing Na+, K+ ions and other catalysts. However, if the powder is used as an adsorbent as is, there are disadvantages, in that the adsorbed material is easily lost during the adsorption action and becomes difficult to recover. In this study, magnesium silicate was used as an adsorbent to remove pollutants (CO2) from the atmosphere. In addition, in order to overcome the disadvantages of using a powder adsorbent material, an inorganic binder (clay) and a reinforcing agent (glass fiber) were added to prepare a molded article which imparted strength to the adsorbent material. Changes in the properties of the adsorbent were confirmed. Changes in the physicochemical properties of the adsorbed material according to the calcination temperature, from 400 to 800°C, were confirmed. In addition, it was confirmed that a molded body with 15 wt% inorganic binder and 4 wt% reinforcing agent had a specific surface area of about 87 m²/g and a strength of 4.63 N. The prepared molded article could adsorb about 0.41 mmol/g of CO2 at atmospheric pressure, confirming its potential use as a CO2 adsorbent.
Pump-Controlled Actuators with Dump Valves
Authors: Kärnell Samuel , Fernlund Emil , Lagerstedt Fabian , Ericson Liselott
Published: February 2022

The electrification trend means an increased focus on the energy efficiency of mobile hydraulic systems. In turn, this means an increased focus on so-called pump-controlled systems, where actuators are controlled by pump flow rather than valve throttling. However, one of the main problems with pump-controlled systems is matching the flow into the pump with its outlet flow. There are many ways of solving this problem, but the solutions tend to be rather bulky and not ideal from a service perspective, since they often rely on accumulators. This paper presents simple but novel pump-controlled concepts, without accumulators. The energy consumption of the presented concepts is analysed and compared to other concepts. The analysis is based on measurements taken on a backhoe loader and the results show that implementation of the presented concepts on the backhoe’s boom actuator can reduce the total power consumption by 50-60 % compared to the original load sensing system. This can be compared with 55-65 %, which is the yield for an ideal, accumulator-based, pump-controlled system on the boom.
The Determination of Hydraulic Motor Displacement
Authors: Michael Paul , Garcia-Bravo Jose
Published: February 2022

Because the geometrical displacement of a pump or motor is very difficult to measure directly, the derived capacity of motors is used to assess the efficiency of positive displacement machines. The current internationally accepted method for deriving the displacement of hydraulic pumps and motors is ISO 8426:2008. Difficulties in accurately assessing derived displacement via ISO 8426:2008 have been reported by several authors. These inaccuracies can lead to efficiency results that exceed 100% in ISO 4409:2019 performance tests. In the presented work, fixed axial, variable axial, and radial piston motors were evaluated at 50°C and 80°C in dynamometer tests. Linear, orthogonal, and semi-randomized data sets were collected. The Wilson, Toet, and an analytical form of the Toet were compared with ISO 8426:2008. In general, the differences between the various methods for deriving displacement were not statistically significant, except in the instance of the axial piston motor. In the axial piston motor, the ISO 8426:2008 derived displacement was approximately 1% lower than the other methods. Use of this lower ISO 8426:2008 displacement in efficiency calculations produced values exceeding 100%. The error in the ISO 8426:2008 derived displacement determination was attributed to difficulties in detecting speeddependent factors that affect displacement when testing is conducted at a single speed. The ISO 8426:2008 method does not provide instructions for calculating derived displacement when data is collected at more than one speed. It is proposed that the One-Step Toet method be incorporated into ISO 8426 as a method for calculating the derived displacement when users opt to measure performance at multiple speeds. This revision will reduce the potential for speed-dependent errors in the determination of derived displacement.
Concept, Simulation Studies and Design for a Novel Concept of the Hydraulic Binary Counter
Authors: Scheidl Rudolf , Scherrer Matthias
Published: February 2022

For the realization of compact and lightweight digital hydraulic cylinder drives for exoskeleton actuation the hydraulic binary counter concept was proposed and studied previously. This counter principle is based on hydraulically piloted switching valves which feature a hysteretic response with respect to the pilot pressure. In first prototypes of that counter bistable mechanical buckling beams realized the hysteretic response. Their performance suffered from high friction in the hinges and high local stresses. Furthermore, they require tight manufacturing tolerances not only of themselves but also of their bearing structure. In this paper, hydraulic feedback from the multi-chamber cylinders is proposed and investigated to realize the reset of lower order valves when a higher order valve switches. To make the hydraulic feedback independent from the system pressure feedback to the valve is done via spring compression. This principle makes bi-stable elements obsolete. The functioning of this principle for a small drive for exoskeleton use is proven by a simple mathematical model and its numerical solution by a MATLAB program. An exemplary embodiment design of the valves with the proposed feedback mechanism shows the feasibility of its practical realization. The application of this concept is not limited to small drives but can be applied for larger drives where multi-chamber cylinders are advantageous, such as for excavators, to save cost and installation space of the many solenoid valves required otherwise.