bluuebunny/crossref_metadata_2025 huggingface dataset:
Errors in performance testing: a comparison of ethanol and temazepam
Authors: Tiplady B. , Hiroz J. , Holmes L. , Drummond G.
Published: April 2003

Both ethanol and benzodiazepines impair psychomotor function. Previous work has suggested that ethanol may have a greater effect on errors while benzodiazepines may cause greater slowing, but this has not been tested in a direct comparison. We assessed the effects of ethanol, at blood concentrations of approximately 80–100 mg/100 ml, compared to two doses of temazepam (20 mg and 30 mg) on psychomotor speed and accuracy and on long-term memory. Sixteen healthy volunteers (eight male, aged 20–25 years) took part in a four-period, placebo-controlled cross-over study. Performance was evaluated using analysis of covariance (critical significance level, p= 0.05) comparing the areas under the response-time curves. Performance on a psychomotor maze showed an almost complete dissociation, with ethanol leading to a substantial and significant increase in errors with little effect on speed, while temazepam slowed performance with no significant change in accuracy. Other tasks showed a similar pattern, but the dissociation was less complete. Handwriting size was substantially increased by ethanol, but not by temazepam. Information processing capacity and long-term memory formation were reduced by a similar amount both for ethanol and 30 mg temazepam. The faster, more error-prone, behaviour on ethanol than with a similarly impairing dose of temazepam has clear implications for the relative potential of the two drugs to contribute to accidents. The results are also important in understanding the differential effects of drugs with different mechanisms of action on human performance.
Amphetamine increases aversive conditioning to diffuse contextual stimuli and to a discrete trace stimulus when conditioned at higher footshock intensity
Authors: Norman C. , Cassaday H. J.
Published: April 2003

Amphetamine can increase conditioning to poor predictors of reinforcement in selective learning tasks (e.g. latent inhibition, LI). In the present study, a noise stimulus was contiguous with footshock or presented at a trace interval. A flashing light background stimulus was used to measure contextual conditioning. Experiment 1 used 1.5 mg/kg and 6 mg/kg dl-amphetamine. Experiments 2 and 3 used 0.5 mg/kg and 1.5 mg/kg d-amphetamine. Unconditioned stimuli parameters (intensity, number, duration) were also manipulated from one experiment to the next. Amphetamine consistently increased conditioning to the background stimulus, and increased conditioning to the trace stimulus at higher footshock intensity (Experiment 3). Thus, amphetamine increased conditioning only to relatively uninformative predictors. The effect on conditioning to trace conditioned stimuli depended on the level of reinforcer but increased conditioning to background did not. Throughout, there was no effect of amphetamine on conditioning of the contiguous stimulus. Thus, the results did not simply arise because amphetamine increased conditioning under any condition in which conditioning without amphetamine was poor. The results are discussed in terms of amphetamine effects on breadth of attention and LI to context.
Ethanol disrupts fear conditioning in C57BL/6 mice
Authors: Gould Thomas J.
Published: April 2003

Ethanol has been demonstrated to disrupt numerous forms of learning. For example, ethanol disrupts fear conditioning in rats. Surprisingly, the opposite result was reported for mice. Because of the importance of mouse models in ethanol research and the predominance of transgenic mice generated on a C57BL/6 background, the present study examined the effects of acute ethanol administration on fear conditioning in C57BL/6 mice. Fear conditioning was chosen because of the apparent contradiction in results between mice and rats, because of its popularity in assessing forebrain-dependent learning and because the task examines two types of learning: (i) the hippocampus-dependent contextual learning and (ii) the hippocampus-independent conditioned stimulus–unconditioned stimulus learning. Dose–response curves were generated for ethanol (0.5, 1.0 and 1.5 g/kg) given on either training day, testing day, or both days. Ethanol, in a dose-dependent manner, disrupted fear conditioning when given on training day or given on both training and testing days. Ethanol given on testing day only did not disrupt fear conditioning. The present results demonstrate that ethanol disrupts fear conditioning in C57BL/6 mice.
Effects of acute procyclidine administration on prepulse inhibition of the startle response in schizophrenia: a double-blind, placebo-controlled study
Authors: Kumari Veena , Zachariah Elizabeth , Galea Adrian , Jones Hugh C. , Das Mrigen , Mehrotra Ravi , Taylor David , Sharma Tonmoy
Published: April 2003

Prepulse inhibition (PPI) of the startle response refers to a reduction in response to a strong stimulus (pulse) if this is preceded shortly by a weak non-startling stimulus (prepulse). Consistent with theories of deficiencies in early stages of information processing, PPI is found to be reduced in patients with schizophrenia. Atypical antipsychotics are found to be more effective than typical antipsychotics in improving PPI in this population. Anticholinergic drugs are often used to control extrapyramidal symptoms induced by antipsychotic medication, especially by typical antipsychotics, in schizophrenic patients and are known to disrupt cognitive functions in both normal and schizophrenic populations. The effect of anticholinergics on PPI in schizophrenia has not yet been examined. This study determined the effects of procyclidine, an anticholinergic drug, on PPI in patients with schizophrenia given risperidone or quetiapine and not on any anticholinergic drugs, employing a placebo-controlled, cross-over design. Under double-blind conditions, subjects were administered oral 15 mg procyclidine and placebo on separate occasions, 2 weeks apart, and tested for acoustic PPI (prepulse 8 dB and 15 dB above the background and delivered with 30-ms, 60-ms and 120-ms prepulse-to-pulse intervals). Procyclidine significantly impaired PPI compared to placebo (assessed as percentage reduction) with 60-ms prepulse-to-pulse trials and increased the latencies to response peak across all trials. The use of anticholinergics needs to be carefully controlled/examined in investigations of information processing deficits using a PPI model and reduced to the minimum level in clinical care of schizophrenia.
A placebo-controlled, cross-over trial of lamotrigine in depersonalization disorder
Authors: Sierra Mauricio , Phillips Mary L. , Ivin Glynis , Krystal John , David Anthony S.
Published: April 2003

There is evidence to support the view that glutamate hyperactivity might be relevant to the neurobiology of depersonalization. We tested the efficacy of lamotrigine, which reduces glutamate release, as a treatment for patients with depersonalization disorder. A double-blind, placebo-controlled, cross-over design was used to evaluate 12 weeks of treatment of lamotrigine. Subjects comprised nine patients with DSM-IV depersonalization disorder. Changes on the Cambridge Depersonalization Scale and the Present State Examination depersonalization/derealization items were compared across the two cross-over periods. Lamotrigine was not significantly superior to placebo. None of the nine patients was deemed a responder to the lamotrigine arm of the cross-over. Lamotrigine does not seem to be useful as a sole medication in the treatment of depersonalization disorder.
A double-blind, placebo-controlled trial of sertraline for depressive symptoms in patients with stable, chronic schizophrenia
Authors: Mulholland Ciaran , Lynch Gerard , King David J. , Cooper Stephen J.
Published: April 2003

There have been no studies specifically examining the efficacy of selective serotonin reuptake inhibitor antidepressants for the symptoms of depression in schizophrenia. This study aimed to determine the efficacy and safety of sertraline as a treatment for depressive symptoms in patients with stable, chronic schizophrenia. The Beck Depression Inventory (BDI) was used as the principal outcome measure and other measures of depressive symptoms as secondary outcome measures. Twenty-six patients were entered into adouble-blind, placebo-controlled, 8-week trial of sertraline and were included in the intent-to-treat (ITT) analysis (13 in each group). Eight patients in the sertraline group and 12 in the placebo group completed at least four weeks in the study and were considered to have had adequate treatment. On the ITT analysis, the mean score on the BDI fell 14.5% for the sertraline group and 5.6% for the placebo group (p> 0.05); the mean score on the Hamilton Depression Rating Scale (HDRS) fell 16.9% for the sertraline group and 8.3% for the placebo group (p > 0.05). When the analysis was repeated for those who had received adequate treatment, the mean BDI score fell by 28% for the sertraline group and 6% for the placebo group (p = 0.1); the mean HDRS score fell 31% for the sertraline group and 8.6% for the placebo group (p= 0.02). On the Clinical Global Impression-Improvement Scale, 10 of the 13 patients on sertraline improved against four of the 13 in the placebo group (p = 0.05). Sertraline-treated patients showed a significant improvement on the anxiety/ depression subscale of the BPRS on ITT analysis (F = 10.1, p = 0.004). There was no significant effect on negative or positive symptoms. Sertraline was well tolerated. The results suggest that sertraline is useful as a treatment for depressive symptoms in schizophrenia.
The pharmacovigilance of mirtazapine: results of a prescription event monitoring study on 13 554 patients in England
Authors: Biswas Pipasha N. , Wilton Lynda V. , Shakir Saad A. W.
Published: April 2003

Mirtazpine is the first noradrenaline and serotonin specific antidepressant. We monitored the safety of mirtazapine as reported in primary practice in England.The exposure data were provided by monitoring the dispensed prescriptions issued between September 1997 and February 1999. Questionnaires sent to GPs provided outcome data. Drowsiness/sedation and malaise/lassitude were the most frequent ADRs (116, 71 respectively) and had the highest incidence density (per 1000 patient-months) in the first month of treatment (58.1, 27.8 respectively). Agitation (73), aggression (70), rash (20), hallucinations (13) and abnormal dreams (31 were unlabelled AES while abnormal liver function tests (12), syncope (8), abnormal behaviour (4) and visual disturbance (3) were labelled AES possibly due to mirtazapine use. Serious suspected ADRs reported were facial oedema (5), allergy (3), bone marrow toxicity (2) and myelodysplasia (1).
Emerging skin-picking behaviour after serotonin reuptake inhibitor-treatment in patients with obsessive–compulsive disorder: possible mechanisms and implications for clinical care
Authors: Denys Damiaan , van Megen Harold J. G. M. , Westenberg Herman G. M.
Published: April 2003

Pathological skin-picking is a self-injurious, impulsive behaviour with repetitive, and ritualistic characteristics. A number of studies show that selective serotonin reuptake inhibitors (SSRIs) may be efficacious in reducing skin-picking behaviour. Two case reports are presented demonstrating that SSRI-treatment may induce or aggravate pathological skin-picking behaviour. Possible mechanisms of SSRI-induced pathological skin-picking and implications for clinical care are discussed.
Zolpidem dependence case series: possible neurobiological mechanisms and clinical management
Authors: Liappas I. A. , Malitas P. N. , Dimopoulos N. P. , Gitsa O. E. , Liappas A. I. , Nikolaou Ch. K. , Christodoulou G. N.
Published: April 2003

Zolpidem is a short-acting imidazopyridine hypnotic that is an agonist at the γ-aminobutyric acid A type (GABAA) receptor. It has been suggested that it acts selectively on α1 subunit-containing GABAA benzodiazepine (BZ1) receptors presenting (contrary to classic benzodiazepines) low or no affinity for other subtypes. Therefore, it has been proposed that it lacks the benzodiazepines-like side-effects, having minimal abuse and dependence potential. Nevertheless, there is a considerable number of zolpidem dependence case reports in the literature. We present eight cases of zolpidem abuse and dependence without criminal record, without history of substance abuse (except for one alcohol abuser), with minor psychiatric disorders, who took zolpidem after physicians prescription in order to deal with their insomnia. However, they became zolpidem abusers not craving its sedative, but its anxiolytic and stimulating action, which helped them to cope with everyday activities. It is possible that, in the high doses that our patients used, zolpidem abandons its selectivity for BZ1 receptors and demonstrates all the actions of classic benzodiazepines. Molecular biology, via possible mutations on GABA receptors, may provide some answers as to why our eight patients (who did not differ much from the thousands of insomniacs who use zolpidem) and other zolpidem abusers, raised the dose progressively, and sought something from the drug other than hypnotic action.
Ultrasonic Acupuncture and the Correlation Between Acupuncture Stimulation and the Activation of Associated Brain Cortices Using Functional Magnetic Resonance Imaging
Authors: Jones Joie P.
Published: April 2003

Using medical imaging techniques, such as fMRI, the stimulation of certain acupuncture points can be shown to correlate with activity in corresponding regions of the brain. Identical activity is also seen if the acupoint is stimulated with a pulse of ultrasound rather than a needle. This article reviews the advantages offered by ultrasonic acupuncture and the impact on the practice of acupuncture.
Absorption of Gamma Radiation as a Possible Mechanismfor Bigu: Theory and Data
Authors: Schwartz Gary E.
Published: April 2003

The qigong state of bigu is believed to be supported by the absorption of qi from the universe. Gamma radiation is ubiquitous in the cosmos and, according to some, may be a possible source of energy for cellular functioning. When the concept of energy is integrated with the concept of dynamical systems, the logic leads to the theory—termed systemic memory—that predicts all systems, from the micro to macro, store information and energy to various degrees. New research indicates that the human body absorbs gamma radiation from the environment and emits high-frequency X rays. There are substantial individual differences in these effects that appear to be related, in part, to the psychological state of the person. Future research can determine if bigu is associated with increased absorption of gamma radiation and/or decreased emission of high frequency X rays. The hypothesis that qi can be viewed as quality information is proposed.
Science and Whole Person Medicine: Enormous Potential in a New Relationship
Authors: Roy Rustum
Published: April 2003

A silent revolution has occurred in the most highly industrialized countries. This is the utilization and acceptance of various healing practices (which for convenience has often been labeled as “alternative medicine,” a.k.a. “whole person healing”) by an enormous fraction of the population. Moreover, this population cohort is much wealthier and better educated than the average citizen. It is no longer possible for this generation in the Western world to ignore or denigrate the medicine and healing practices used by hundreds of millions in other cultures. What is obviously needed is a retreat from the innate skeptical reaction of much of the stance of western medicine, the development of a mutual respect for other cultures and their achievements, and a genuinely open, scientific and wholistic approach to the issues, especially in this context, to other practices of whole person healing.
Technological Fix: Sex Determination in India
Authors: Varma Roli
Published: April 2003

Prenatal diagnostic technologies have been used for the purpose of detecting sex—leading to abortion of female fetuses—and have posed new challenges to the already difficult question of social justice for women in India. This article reports findings from a case study conducted with 25 women who had used prenatal diagnostic technologies for sex determination.Against the common belief that Indian society is “improving” because of 21st-century medical technology, this case study shows that the social context has given a patriarchal value to such advanced technology in India. Furthermore, it sheds light on why prenatal diagnostic technologies have taken a different route in India.It shows that reasons for accepting the use of prenatal diagnostic technologies for sex determination by women are diverse and complex.
Copernicus, Darwin, and Human Embryos
Authors: Resnik David B.
Published: April 2003

This article explores the impact of the Copernican and Darwinian revolutions on our view of human-kind’s place in the universe and locates the current debates about stem cell research within this larger sociohistorical context. The article argues that the past 500 years of science support the idea that the morally significant features of human beings reside in the unique cognitive, emotive, and social traits that are often described as the “soul,” not in any special features of human physiology, anatomy, or genetics.
Renewable Energy and the City: Urban Life in an Age of Fossil Fuel Depletion and Climate Change
Authors: Droege Peter
Published: April 2003

The large-scale and inevitable shift away from the fossil- and nuclear-powered economic model will have dramatic consequences. The author discusses these by looking at the impacts on and of one of the greatest accomplishments of 20th-century culture: global urbanization, modern cities, and urban life. Technological implications, urban form impacts, policy dimensions, institutional ramifications, and cultural issues all form the very nexus of challenges confronting decision makers worldwide at local, regional, and global levels.
Less Energy, a Better Economy, and a Sustainable South Korea: An Energy Efficiency Scenario Analysis
Authors: Wang Young-Doo , Byrne John , Kim Jung wk , Kim Jong dall , Boo Kyung-Jin , Yun Sun-Jin , Mun Yu Mi , Kim Chung-Kyung , Soh Yongkyeong , Yamaguchi Takuo
Published: April 2003

An energy efficiency scenario (Joint Institute for a Sustainable Energy and Environmental Future) demonstrates that an energy future built on the use of cost-effective, high-efficiency technologies is clearly within the grasp of South Korea and would justify a nuclear power moratorium with significantly lower carbon dioxide emissions. This is a promising result, especially because applications of other sustainable energy options, such as renewables, decentralized technologies, material recycling/reuse, ecologically based land use planning, forest conservation, sustainable agriculture, and redirection of economic development toward an environment-friendly industrial base, are not included in the analysis. Here lies one of the most fundamental policy choices of the newcentury: Will we build a sustainable energy and environmental future, or will we send forward the burdens and risks of a policy regime that is unwilling to value the future beyond the satisfaction of short-term interests and convenience? It is a critical time for South Korean policy making.
Switching on the Future: Midwestern Models for a Clean Energy Transition
Authors: Noble Michael T. , Hoffman Steven M.
Published: April 2003

A clean energy future is both plausible and in the best interests of the country. The Upper Midwest, acting in concert with appropriate policy changes at the national level, could play a pivotal role in helping the nation move in that direction. As the past century’s embrace of centralized power is beginning to weaken, a variety of policy drivers, including concerns about energy system capacity and reliability, the improvement of public health by reducing pollution, the enhancement of national security by decreased reliance on nuclear power, and the need to curtail greenhouse gas emissions, are beginning to make clear the outlines of this energy transition. The proposals offered by the Environmental Lawand Policy Center and Minnesotans for an Energy-Efficient Economy rely on proven, economical, and environmentally sustainable technology options. An aggressive development plan featuring efficiency, wind, and other renewable resources will be a significant first step in solving the climate change problem.
Revisiting the Winning of the West
Authors: Gilliam Rick
Published: April 2003

In 1996, the Land and Water Fund of the Rockies (LAW Fund), a nonprofit environmental lawand policy center based in Boulder, Colorado, released How the West Can Win: A Blueprint for a Clean and Affordable Energy Future. The blueprint found that rapid growth in the West would lead to another round of fossil fuel–fired power plants and the associated environmental impacts unless policy makers changed course toward a more sustainable energy future. The study provided a set of strategies that lawmakers, regulators, and other stakeholders could use to help implement such a course change. It is concluded that the blueprint’s recommendations are even more salient than they were 5 years ago. The article leads off with an overview of changes in the electric industry over the past 5 years in the interior West and concludes with a review of the executive summary of the LAW Fund’s 1996 report, the policy directives of which remain valid today.
Fuel Cell Cars: Panacea or Pipe Dream?
Authors: Karimi Shahram , Foulkes Frank R.
Published: April 2003

Hydrogen fuel cells are likely to begin replacing conventional internal combustion engines as a power generation method for transportation applications in the near future. A life cycle analysis of a hydrogen fuel cell was performed to examine the major environmental impacts of such an engine in comparison with an internal combustion engine. To quantify the emissions, material consumption and energy consumption were identified by carrying out mass and energy balances, respectively. Wherever possible, a “well-to-wheel” approach was adopted to identify all the processes involved. The size of the hydrogen fuel cell engine selected was 60 kW, which would power a small automobile weighing around 800 kg. This report briefly describes the materials and processes involved in assembling such an engine, with their respective environmental impacts. Different technologies to build a hydrogen economy also are discussed because hydrogen is an integral part of most fuel cell engines. The main conclusion is that if an environmentally sustainable system of hydrogen production is found, the use of hydrogen and, in turn, hydrogen fuel cell cars would be highly beneficial. Thus, the theoretical potential of fuel cells is great for environmental benefits, but practical applications might prove otherwise.
Technological, Energy, and Organizational Limits to Material Progress: A Historical Perspective
Authors: Lemon James
Published: April 2003

This article examines the social, technological, and energy limits to growth from a historical perspective. Various suggestions to surmount these limits are evaluated and found to be wanting, especially in the face of a rapidly evolving energy crisis as the era of oil comes to an end. It concludes that there are genuine reasons to be concerned about the human prospect.
Development of Environmental Knowledge and Attitudes in Engineering Students
Authors: Kennedy Christopher , Hyde Rosamund , Karney Brya
Published: April 2003

A test was administered to 102 engineering students to ascertain how engineering education influences their environmental knowledge and attitudes. Answers to definitional and factual questions in a forced-answer section demonstrated that students were improving their technical knowledge, but responses to more subtle questions were mixed. Answers to attitudinal questions exhibited a trend towards increased environmental awareness. For open-ended questions, posttest results showed an increase in knowledge of engineering work. Over 80% of the students considered themselves to have a caring attitude toward the environment, with the “three R’s” and green transportation choices most commonly cited. Engagement in research, education, or advocacy doubled from pretest to posttest. Air pollution and solid waste disposal most frequently influenced students’ attitudes toward the environment. Outdoor experiences were the most frequently mentioned source of information; university courses rose from 4% to 15% on the posttest. Only 40% of the students could name an environmental role model.
A Sociotechnical Mapping of Domestic Biomass Heating Systems in Austria
Authors: Rohracher Harald
Published: April 2003

Introducing the perspective of science and technology studies (STS) to the analysis of the design and adoption of environmentally friendly technologies may help develop more effective and diversified strategies for an environmentally oriented technology policy. A case study of the organizational context and sociotechnical network of modern domestic bio-mass heating systems in Austria demonstrates the usefulness of such an approach. Mapping out the sociotechnical system and the guiding visions surrounding the domestic use of biomass and the dynamics of its development may help find effective levers for a technology policy focusing on regional and interactive strategies to influence the organizational context of a technology. In the case of biomass, the target of technology policy shifts from technological research and development to information programs and vocational training for installers, organizational infrastructures for the supply of wood chips, or the elaboration of innovative energy services.
The Central Dilemma of China’s S&T Policy
Authors: Li Zhen , Handberg Roger
Published: April 2003

The central dilemma for Chinese science and technology (S&T) policy is how to reform and improve such policies without the deleterious interventions of the past. In a centralized S&T system, government intervention has proved at times disruptive and even destructive to efforts at national economic advancement. The historical processes within China have produced an S&T system with enormous potential but plagued by difficulties in investment strategies and capacity for innovation. Simply put, investment levels have been low, and the capacity to generate more funding is lacking. How to improve the situation and confront the competitive challenges posed by a more transparent international economic system are considered in the last part of the article.
“Innovation Systems in Transition: Preconditions for Success”: The Electronics Sector in the Former Soviet Union
Authors: Smith Heidi
Published: April 2003

During the Soviet period, the microelectronics industry in the former Soviet Union (FSU) owed its existence to the political and military objectives of the Communist Party. Consequently, investment in the industry was planned to meet the security needs of the Cold War international environment. Since the breakup of the Soviet Union, there has been a reduction in emphasis away from the mass production of electronic devices suited to military and defense needs. The emergence of a huge rise in consumer demand for non-Soviet electronic goods has prompted a fundamental shift in production regimes to meet civilian, customer demands rather than military, political objectives. The electronics industry is being re-created because its original raison d’être has disappeared. In the process, many issues facing other sectors and countries during the transition are borne out. This article assesses the potential for innovation in the microelectronics sector in the FSU.
Fuzzy Logic: Computers, Education, and Language in a Techno-Illogical World
Authors: Rose Ellen
Published: April 2003

This article disrupts the logic of the “just-a-tool” argument, a powerful rhetorical device commonly offered as a rationale for using computers in education (and health care and other areas of society). Although this argument is articulated in many ways, its essence is the contention that computers are merely instructional tools, like blackboards or pencils, that can be used to enhance learning and therefore should be used in classrooms. The just-a-tool argument is difficult to challenge because it automatically constructs counterarguments as illogical; they necessarily become arguments against using technology to improve the human condition. However, an analysis of the just-a-tool argument reveals that far from being logical and unassailable, it is both invalid and unsound. This “techno-illogic,” as the author calls it, arises when wisdom is subjugated to the dictates of technological “rationality,” and it is something that people must learn to recognize and defend against.
Reluctant Rebels: Women Scientists Organizing
Authors: Braselmann Sylvia
Published: April 2003

The history of U.S. women scientists’ organizations from the 19th century until the 1960s reflects both women’s relative powerlessness within the science community and their reluctance to challenge discrimination against them. Since the 1960s, feminist activism, together with the increase in the number of women trained in science, have made discrimination against women in science more obvious and less tolerable. The founding of the first explicitly equity-seeking organization, the Association of Women in Science (AWIS), in 1971 is a watershed. Today, women scientists are willing to band together so long as the promises of meritocracy remain unfulfilled.
Geek Mythology
Authors: Margolis Jane , Fisher Allan
Published: April 2003

The fact that information technology is becoming the lingua franca of 21st-century business makes it of more than passing interest that the proportion of women selecting and succeeding in the field is in decline. In Margolis and Fisher’s Unlocking the Clubhouse: Women in Computing, the authors analyze the problem and report on how it is being partially righted at Carnegie Mellon University. The following selections are from Chapters 4 and 8 of their book.
Is MIT an Exception? Gender Pay Differences in Academic Science
Authors: Ginther Donna K.
Published: April 2003

This study uses data from the Survey of Doctorate Recipients to evaluate gender differences in salaries for academic scientists. Over time gender salary differences can partly be explained by differences in observable characteristics for faculty at the assistant and associate ranks. Substantial gender salary differences for full professors are not explained by observable characteristics. Between 1973 and 1997, very little has changed in terms of gender salary and promotion differences for academics in science. After evaluating potential explanations, the author concludes that gender discrimination similar to that observed at MIT accounts for unexplained gender disparities.
Women and Science: Issues of Power and Responsibility
Authors: Gabetta Giovanna
Published: April 2003

This article derives from the results of a questionnaire circulated to an international set of women working mainly in large companies in the field of science and technology. It is composed of 127 respondents from 17 different countries. The women in the sample are, as a whole, happy in their work and their choice of a career. Only a few of them are, however, successful managers; 85% of the sample have less than 10 people reporting to them.
A New Trivium and Quadrivium
Authors: Bugliarello George
Published: April 2003

Today’s conflicts between the views that the humanities hold of science and engineering and the views science and engineering hold of the humanities weaken the very core of our culture. Their cause is lack of integration in today’s education among subjects that hark back to the medieval trivium and quadrivium. A new trivium is needed to provide every educated person with a basic understanding of the endeavors and instruments that help us address our world and shape a new morality—the humanities, in the noblest sense of the word, to civilize, science to understand nature, and engineering, broadly defined, to encompass the kindred activities that modify nature. Integration of these endeavors is urgent. It involves, in turn, an intimate interaction (the “biosoma”) of biological organisms, society, and machines—a new quadrivium. No domain can any longer be considered and learned in isolation.
Intranets, Community, and Social Capital: The Case of Williams Bay
Authors: Arnold Michael
Published: April 2003

Many people in the Western world are distressed about a perceived loss of community and community values, and it has been argued that the key difference between strong and weak community lies in social capital, that is, networks of civic engagement and norms of generalized reciprocity. In the context of social capital, the article introduces a research project that focuses on a community intranet installed in a new housing development in Melbourne, Australia. The prospects for the success of the community intranet in linking residents to one another, increasing participation in local civic organizations, encouraging reciprocity, and thereby fostering social capital are surveyed in both a priori and empirical terms. The article concludes with the questions to be used in the case study to assess whether these prospects are realized in the case at hand.
Ethics, Technology, and the Future: An Intergenerational Experience in Engineering Education
Authors: Berne Rosalyn W.
Published: April 2003

How do engineering educators adequately and richly introduce to young engineers the perplexing ethical issues associated with the development of new technologies? Robotics, nanotechnology, cloning, cyberintelligence, and genetic engineering, for example, each hold the potential to radically alter the fundamental nature of human life. Senior citizens in our society have a lifetime of experience adopting new technologies into their lives. Through an intergenerational dialogue, undergraduate engineers can come to appreciate and understand what technological change can really mean, both in practical and ethical terms. This article explores the use of intergenerational dialogue as a learning tool, with a focus on the experience of students enrolled in a required engineering ethics course. Reactions and thoughts recounted in this article from both undergraduate engineers and senior citizens signify the immeasurable educational value of intergenerational exploration and its effectiveness in examining the ethical questions connected to the development of new technologies.
Engineering Literacy in High School Students
Authors: Robinson Mike , Kenny Bruce
Published: April 2003

This article reports pretest and posttest results of the infusion of engineering principles and design into an existing ninth-grade integrated science class. The results indicated that more knowledge of engineering makes attitudes of high school students more favorable toward engineering. The results of infusing engineering topics into an existing science curriculum were also compared with an earlier study of a formal 3-week engineering unit taught to ninth-grade students in another high school. The results of that comparison indicated that a formal unit on engineering was more successful in improving student attitudes toward engineering than the infusion of engineering topics into an existing science unit. The article also presents information on a capstone engineering course for preservice and in-service science and mathematics teachers. That course was designed with collaboration from the colleges of engineering and education with the goal of increasing the interest of high school students in careers in engineering.
Climate Change and Biotechnology: Moving Toward a Carbohydrate-Based Economy
Authors: Mehta Michael D.
Published: April 2003

Advances in biotechnology make possible the transition toward a carbohydrate-based economy. By modifying plants to sequester more carbon and survive on marginal lands, more cost-effective means for using biomass are explored. This article discusses how better use of biomass can reduce greenhouse gas emissions and poses questions about how this transition can occur.
iMPACT3: Internet-Based Development and Administration of Utility Elicitation Protocols
Authors: Lenert L. A. , Sturley A. , Watson M. E.
Published: April 2003

iMPACT3 (Internet Multimedia Preference Assessment Instrument Construction Tool, version 3) is a software development environment that helps researchers build Internet-capable multimedia utility elicitation software programs. The program is a free, openly accessible Web site (http://preferences.ucsd.edu/impact3/asp). To develop a utility elicitation software program using iMPACT3, a researcher selects modular protocol components from a library and custom tailors the components to the details of his or her research protocol. iMPACT3 builds a Web site implementing the protocol and downloads it to the researcher’s computer. In a study of 75 HIV-infected patients, an iMPACT3-generated protocol showed substantial evidence of construct validity and good internal consistency (logic error rates of 4% to 10% and procedural invariance error rates of 10% to 26%, depending on the elicitation method) but only fair 3- to 6-week test-retest reliability (intraclass correlation coefficient = 0.42 to 0.55). Further work may be needed on specific utility assessment procedures, but this study’s results confirm iMPACT3’s feasibility in facilitating the collection of health state utility data.
Antibiotic Prescribing Decisions of Generalists and Infectious Disease Specialists: Thresholds for Adopting New Drug Therapies
Authors: Metlay Joshua P. , Shea Judy A. , Asch David A.
Published: April 2003

The objective of this study was to examine whether physicians are willing to continue to use older antibiotics in the face of drug resistance in order to preserve newer antibiotics for future use. The study was a national sample of 398 generalist physicians and 429 infectious disease (ID) specialists. Clinical vignettes prompted respondents to select the level of resistance to a hypothetical older antibiotic at which they would prefer a newer antibiotic without any current resistance in the treatment of a patient with pneumococcal pneumonia. Vignettes varied in the site of care of the patient as a proxy for variation in disease severity. Respondents significantly reduced their threshold for switching to a newer antibiotic as disease severity increased. Generalists were more responsive to disease severity than ID specialists. Thus, the adoption of recommendations to limit overuse of newer antibiotics may be variable across clinical settings and providers, reducing the impact of these recommendations on emerging resistance.
Costs and Benefits of Enforcing Housing Policies to Prevent Childhood Lead Poisoning
Authors: Brown Mary Jean
Published: April 2003

Background. Lead poisoning remains an important, yet entirely preventable disease among young children. This article compares the costs and benefits of strict versus limited enforcement of lead poisoning prevention housing policies in preventing additional cases of childhood blood lead elevation. Methods. The author conducted decision analysis using population-based data that compared recurrence of childhood lead exposure in 2 urban areas with different enforcement capacity, and cost data from a federal project and from medical and public health literature. Results. Strict enforcement prevented additional cases, resulting in $45,360 savings from decreased medical and education costs and increased productivity for protected children. The model was robust to changing estimates of followup, housing repairs, relocation, and increases in lead levels over baseline. No cost savings were realized by strict enforcement if the probability of recurrence in limited units was 44% lower than estimated, or if fewer children were identified in limited versus strict enforcement units. If the discount rate for future productivity losses was ≥7.5%, strict enforcement did not lower costs. Conclusion. This analysis suggests that strict enforcement of housing policies to prevent childhood blood lead elevation results in decreased societal costs due to the avoidance of future medical and special education and to increased productivity of resident children.
The Relationship between Risk Attitude and Treatment Choice in Patients with Relapsing-Remitting Multiple Sclerosis
Authors: Prosser Lisa A. , Kuntz Karen M. , Bar-Or Amit , Weinstein Milton C.
Published: April 2003

Background. Many patients with multiple sclerosis (MS) eligible for β -interferons or glatiramer acetate have chosen to forgo or discontinue treatment. The objective of this study was to evaluate risk attitude as a patient characteristic related to treatment choice for patients with MS. Methods. Sixty-two MS patients completed a survey on treatment history, risk preference, and socioeconomic and clinical variables. Multinomial logistic regression was used to assess the relationship between treatment choice and risk attitude. Risk attitude was measured using a standard gamble question on short-term health outcomes. Results. More risk-seeking patients were less likely to choose treatment compared with more risk-averse patients (P < 0.01). For patients who discontinued treatment, the explanatory variable of significance was severity of side effects (P < 0.05). Conclusions. Risk attitude is a patient characteristic related to treatment initiation in patients with MS. This could be an important factor to consider when identifying optimal treatment decisions for individual patients.
A Meta-Analysis of Utility Estimates for HIV/AIDS
Authors: Tengs Tammy O. , Lin Ting H.
Published: April 2003

The authors performed a meta-analysis to derive pooled utilities for HIV/AIDS and to assess the relative importance of study design characteristics in predicting utilities. Twenty-five articles were identified reporting 74 unique utilities elicited from 1956 respondents. The authors used a hierarchical linear model to perform the meta-analysis, with disease stage, elicitation method, respondent type, and the upper-bound and lower-bound labels for the utility scale as the independent variables. Disease stage (P = 0.016) and respondent type (P = 0.014) were significant predictors of utility. Elicitation method was of marginal significance (P = 0.052). Bounds were not significant. Pooling utilities, the authors estimate a utility of 0.70 for AIDS, 0.82 for symptomatic HIV, and 0.94 for asymptomatic HIV when the time tradeoff method is used to elicit utilities from patients and the scale ranges from death to perfect health. The pooled utilities reported here should be of great use to researchers performing cost-utility analyses of interventions for HIV/AIDS.
Willingness to Pay for What? A Note on Alternative Definitions of Health Care Program Benefits for Contingent Valuation Studies
Authors: Currie Gillian R. , Donaldson Cam , O’Brien Bernie J. , Stoddart Greg L. , Torrance George W. , Drummond Michael F.
Published: April 2003

The authors examine a number of ways in which willingness to pay (WTP) can be defined for measurement and use in a cost-benefit analysis (CBA) of a collectively funded health care program. They show how ambiguous specification of the program consequences that respondents should consider in their WTP responses can lead to problems of double counting or zero counting in a subsequent CBA. An example is whether the value of lost time from work because of poor health should be included by a CBA analyst (e.g., valued at the wage rate) as a separate cost item or whether this has already been monetized and included in respondents’ WTP data. The authors highlight how differences in assumed or actual institutional structures are often ignored in measures of WTP and the consequences of this for the interpretation of WTP data.
Visual Acuity following Cataract Surgeries in Relation to Preoperative Appropriateness Ratings
Authors: Tobacman Joanne K. , Zimmerman Bridget , Lee Paul , Hilborne Lee , Kolder Hansjoerg , Brook Robert H.
Published: April 2003

The authors initiated this study to consider if the formal preoperative assessment of appropriate or inappropriate utilization of cataract surgery by an expert panel could predict postoperative improvement or decline in visual acuity. They evaluated the association between ratings of appropriateness, as determined by the RAND-UCLA method, and measurements of postoperative visual acuity using Fisher’s exact tests for tables greater than 2 × 2. For 768 patients, improvement of at least 2 Snellen chart lines occurred in 89% of surgeries rated as appropriate or appropriate and crucial, 68% rated as uncertain, and 36% rated as inappropriate ( P < 0.0001, Fisher’s exact test). These results provide evidence supporting the validity of the RAND-UCLA method to assess the appropriateness of surgery.
The Relationship between Treatment Objectives and Practice Patterns in the Management of Urinary Tract Infections
Authors: Flach Stephen D. , Longenecker J. Craig , Tape Thomas G. , Bryan Teresa J. , Parenti Connie , Wigton Robert S.
Published: April 2003

Objective. To describe physicians’ goals when treating uncomplicated urinary tract infections (UTIs) and the relationship between goals and practice patterns. Study design. Analysis of survey results. Population. Primary care physicians. Outcomes measured. Self-reported treatment objectives and practice patterns. Results. Most physicians reported their UTI management was convenient for the patient (81.3%). Fewer stated they minimized patients’ costs (53.4%), made an accurate diagnosis (56.7%), or avoided unnecessary antibiotics (40.9%). Physicians who stressed convenience or minimizing patient expenses were less likely to use many resources (urine culture, microscopic urinalysis, followup visits and tests, and prolonged antibiotic treatment) and more likely to use telephone treatment. Physicians who stressed accurate diagnoses or avoiding unnecessary antibiotics were more likely to use the same resources and less likely to use telephone treatment. Conclusion. UTI management goals vary across physicians and are associated with different clinical approaches. Differences in treatment objectives may help explain variations in practice patterns.