bluuebunny/crossref_metadata_2025 huggingface dataset:
A SMYD3/ITGB6/TGFβ1 Positive Feedback Loop Promotes the Invasion and Adhesion of Ovarian Cancer Spheroids
Authors: Jiang Yahui , Zhou Tianyu , Shi Yiwen , Feng Weiwei , Lyu Tianjiao
Published: September 2021

Background

Implantation metastasis is the main means of dissemination in ovarian cancer. Our previous studies showed that SET and MYND domain-containing protein 3 (SMYD3) expression was higher in ovarian cancer spheroids than in monolayers. SMYD3 enhancement of spheroid invasion and adhesion is mediated by the downstream effectors ITGB6 and ITGAM. However, the potential mechanisms underlying the SMYD3/integrin-mediated invasion and adhesion of spheroids still need to be explored.

Methods

Western blotting was used to examine the expression of SMYD3, ITGB6 and downstream molecules under different treatments. Immunofluorescence was used to detect the expression of F-actin, E-cadherin and N-cadherin. Anti-ITGB6 antibody-based inhibition and dual-luciferase reporter assays were used to confirm the binding between ITGB6 and latent TGFβ1. Transwell invasion, adherence and 3D tumor spheroid invasion assays were employed to test the effects of TGFβ1 on the invasion and adhesion of ovarian cancer spheroids. ELISA was performed to assess the release of latent TGFβ1 from ovarian cancer spheroids.

Results

SMYD3 and ITGB6 activated the TGFβ1/Smad3 pathway and then induced the upregulation of Snail, Vimentin and N-cadherin and the downregulation of E-cadherin in 3D-cultured ovarian cancer spheroids. In this process, latent TGFβ1 could bind to ITGB6 and become activated to stimulate the Smad3 pathway. Moreover, SMYD3 and ITGB6 could facilitate the release of latent TGFβ1 from 3D-cultured ovarian cancer spheroids. Interestingly, TGFβ1 could promote the expression of SMYD3 and ITGB6 via feedback. This positive feedback loop could further amplify the biological effect and promote the invasion and adhesion of ovarian cancer spheroids.

Conclusion

Our results demonstrated that the SMYD3/ITGB6/TGFβ1-Smad3 positive feedback loop could promote the invasion and adhesion of ovarian cancer spheroids by upregulating the expression of N-cadherin, Snail, and Vimentin and downregulating the expression of E-cadherin. Thus, our study unmasked the mechanism of SMYD3- and ITGB6-induced ovarian cancer metastasis and provides new ideas for targeted ovarian cancer treatment.
Knockdown of m6A Reader IGF2BP3 Inhibited Hypoxia-Induced Cell Migration and Angiogenesis by Regulating Hypoxia Inducible Factor-1α in Stomach Cancer
Authors: Jiang Libin , Li Yingxia , He Yixin , Wei Dapeng , Yan Lvyin , Wen Hongtao
Published: September 2021

Hypoxia is a common feature of solid tumors including stomach cancer (SC) and is closely associated with cancer malignant progression. N6-methyladenosine (m6A), a common modification on RNA, is involved in the regulation of RNA fate and hypoxic responses in cancers. However, the interaction between m6A reader insulin-like growth factor-II mRNA-binding protein 3 (IGF2BP3) and SC hypoxic microenvironment is poorly defined. In the present study, expression levels of IGF2BP3 and hypoxia inducible factor-1α (HIF1A) were examined by bioinformatics analysis and RT-qPCR and western blot assays. Cell migratory ability was assessed through Transwell and wound healing assays. The angiogenic potential was evaluated by VEGF secretion, tube formation, and chick embryo chorioallantoic membrane (CAM) assays. The interaction between IGF2BP3 and HIF1A was explored using bioinformatics analysis and RIP and luciferase reporter assays. The results showed that IGF2BP3 and HIF1A were highly expressed in SC tissues and hypoxia-treated SC cells. IGF2BP3 knockdown inhibited hypoxia-induced cell migration and angiogenesis in SC. IGF2BP3 positively regulated HIF1A expression by directly binding to a specific m6A site in the coding region of HIF1A mRNA in SC cells. HIF1A overexpression abrogated the effects of IGF2BP3 knockdown on hypoxia-induced cell migration and angiogenesis in SC. In conclusion, IGF2BP3 knockdown inhibited hypoxia-induced cell migration and angiogenesis by down-regulating HIF1A in SC.
Comparison of Perioperative, Renal Functional, and Oncological Outcomes Between Off-Clamp and On-Clamp Robot-Assisted Partial Nephrectomy for Renal Tumors: An Updated Evidence-Based Analysis
Authors: Huang Yin , Cao Dehong , Chen Zeyu , Chen Bo , Li Jin , Guo Jianbing , Dong Qiang , Wei Qiang , Liu Liangren
Published: September 2021

Objectives

We aimed to report the latest and largest pooled analysis and evidence update to compare the perioperative, renal functional, and oncological outcomes between off-clamp and on-clamp robot-assisted partial nephrectomy (RAPN) for renal tumors.

Patients and methods

We performed a systematic literature search using PubMed, Embase, and Web of Science up to August 2021 for studies that compared the efficacy and/or safety between off-clamp and on-clamp RAPN for renal tumors. Outcomes measured were operating time, estimated blood loss (EBL), conversion rate, length of stay (LOS), complication rate, transfusion rate, long-term % decrease in estimated glomerular filtration rate (eGFR), positive surgical margin rate, and recurrence rate.

Results

A total of 21 eligible articles involving 4,493 patients (1,274 off-clamp versus 3,219 on-clamp) were included for the evidence synthesis. Baseline characteristics of the two groups were similar in all outcomes except that lower R.E.N.A.L. score and smaller tumor size were observed in the off-clamp group. Pooled analysis showed shorter operative time, higher EBL, and lower complication rate in the off-clamp group. No significant difference was observed in the conversion rate, LOS, and transfusion rate. The recurrence rates were similar in the two groups, while a lower positive surgical margin rate was observed in the off-clamp group. Finally, the off-clamp group had a superior postoperative renal functional outcome.

Conclusions

Given the presence of heterogeneity and potential bias, urologists should select the clamp strategy based on their experience and patient-specific factors.
MEDEX 2015: Prophylactic Effects of Positive Expiratory Pressure in Trekkers at Very High Altitude
Authors: Rupp Thomas , Maufrais Claire , Walther Guillaume , Esteve François , Macdonald Jamie Hugo , Bouzat Pierre , Verges Samuel
Published: September 2021

Purpose: Positive expiratory pressure (PEP) breathing has been shown to increase arterial oxygenation during acute hypoxic exposure but the underlying mechanisms and consequences on symptoms during prolonged high-altitude exposure remain to be elucidated.

Methods: Twenty-four males (41 ± 16 years) were investigated, at sea level and at 5,085 m after 18 days of trekking from 570 m. Participants breathed through a face-mask with PEP = 0 cmH2O (PEP0, 0–45th min) and with PEP = 10 cmH2O (PEP10, 46–90th min). Arterial (SpO2), quadriceps and prefrontal (near infrared spectroscopy) oxygenation was measured continuously. Middle cerebral artery blood velocity (MCAv, transcranial Doppler), cardiac function (2D-echocardiography), extravascular lung water accumulation (UsLC, thoracic ultrasound lung comets) and acute mountain sickness (Lake Louise score, LLS) were assessed during PEP0 and PEP10.

Results: At 5,085 m with PEP0, SpO2 was 78 ± 4%, UsLC was 8 ± 5 (a.u.) and the LLS was 2.3 ± 1.7 (all P < 0.05 versus sea level). At 5,085 m, PEP10 increased significantly SpO2 (+9 ± 5%), quadriceps (+2 ± 2%) and prefrontal cortex (+2 ± 2%) oxygenation (P < 0.05), and decreased significantly MCAv (−16 ± 14 cm.s–1) and cardiac output (−0.7 ± 1.2 L.min–1) together with a reduced stroke volume (−9 ± 15 mL, all P < 0.05) and no systemic hypotension. PEP10 decreased slightly the number of UsLC (−1.4 ± 2.7, P = 0.04) while the incidence of acute mountain sickness (LLS ≥ 3) fell from 42% with PEP0 to 25% after PEP10 (P = 0.043).

Conclusion: PEP10 breathing improved arterial and tissue oxygenation and symptoms of acute mountain sickness after trekking to very high altitude, despite reduced cerebral perfusion and cardiac output. Further studies are required to establish whether PEP-breathing prophylactic mechanisms also occur in participants with more severe acute mountain sickness.
High Proteoglycan Decorin Levels Are Associated With Acute Coronary Syndrome and Provoke an Imbalanced Inflammatory Response
Authors: Zhuang Lingfang , Ge Yulong , Zong Xiao , Yang Qian , Zhang Ruiyan , Fan Qin , Tao Rong
Published: September 2021

Background and Aims: Acute coronary syndrome (ACS) has become one of the most common causes of disability. It is thus important to identify ACS early in the disease course of patients using novel biomarkers for prompt management. Decorin (DCN) was well-acknowledged for its effect on collagen fibrillogenesis and maintaining tissue integrity. Additionally, DCN could release as secreted proteoglycan under pathological conditions. Hence, we aimed to determine the relationship between serum DCN concentration and ACS.

Methods: A total of 388 patients who underwent coronary angiography (CAG) in the cardiovascular center of Ruijin Hospital between June 2016 and December 2017 were enrolled in this study. Blood samples were drawn during CAG surgery to determine the serum DCN level of patients with ACS (n = 210) and control subjects (n = 178) using enzyme-linked immunosorbent assay.

Results: We found that the serum DCN levels of ACS patients were elevated compared with those of the control subjects (13.59 ± 0.50 vs. 13.17 ± 0.38, respectively, p < 0.001). Furthermore, the serum DCN level, after being adjusted with other cardiovascular factors, was independently associated with ACS. Moreover, an increased serum DCN level was positively correlated with the number of white blood cells and the level of high-sensitivity C-reactive protein (R = 0.3 and 0.11, respectively). Mechanistically, DCN might have elicited an imbalanced inflammatory response during cardiac ischemia by suppressing the expression of anti-inflammatory genes.

Conclusion: Serum DCN is a novel biomarker of ACS and contributes to the increased inflammatory response in ischemic heart disease.
Data Driven Explanation of Temporal and Spatial Variability of Maize Yield in the United States
Authors: Wang Lizhi
Published: September 2021

Maize yield has demonstrated significant variability both temporally and spatially. Numerous models have been presented to explain such variability in crop yield using data from multiple sources with varying temporal and spatial resolutions. Some of these models are data driven, which focus on approximating the complex relationship between explanatory variables and crop yield from massive data sets. Others are knowledge driven, which focus on integrating scientific understanding of crop growth mechanism in the modeling structure. We propose a new model that leverages the computational efficiency and prediction accuracy of data driven models and incorporates agronomic insights from knowledge driven models. Referred to as the GEM model, this model estimates three independent components of (G)enetics, (E)nvironment, and (M)anagement, the product of which is used as the predicted crop yield. The aim of this study is to produce not only accurate crop yield predictions but also insightful explanations of temporal and spatial variability with respect to weather, soil, and management variables. Computational experiments were conducted on a data set that includes maize yield, weather, soil, and management data covering 2,649 counties in the U.S. from 1980 to 2019. Results suggested that the GEM model is able to achieve a comparable prediction performance with state-of-the-art machine learning models and produce meaningful insights such as the estimated growth potential, effectiveness of management practices, and genetic progress.
“Why Are You Running Away From Social Media?” Analysis of the Factors Influencing Social Media Fatigue: An Empirical Data Study Based on Chinese Youth
Authors: Liu Yixuan , He Jianping
Published: September 2021

In the digital era, social media is increasingly permeating the fragmented lives of people. While enjoying the convenience and speed of online socializing, people are gradually surrounded by a variety of information. Through observations and interviews, we found that young people are plagued by negative comparisons, interaction dysfunction, information overload, social overload, and intergenerational communication in the process of participating in social media. Increasing numbers of young people feel overwhelmed in the process of online socialization and the phenomenon of social media fatigue (SMF) gradually spreads. This study combined the existing relevant theoretical models of the influencing factors of SMF and the real-life empirical materials of youth groups. Furthermore, this study enriched into new research variables and validated the data of relevant variables through a questionnaire survey (n= 663) to explore the influencing factors of SMF of youth groups and inductively analyze the inner logic of the emergence of SMF among such groups. It was found that negative comparison, interaction dysregulation, information overload, social overload, self-efficacy, and impression management all had significant positive effects on SMF behaviors, while privacy anxiety and intergenerational communication had no significant positive effects on SMF behaviors.
Psychological Inflexibility and Loneliness Mediate the Impact of Stress on Anxiety and Depression Symptoms in Healthcare Students and Early-Career Professionals During COVID-19
Authors: Bonilla-Sierra Patricia , Manrique-G Alexis , Hidalgo-Andrade Paula , Ruisoto Pablo
Published: September 2021

Background: The current mental health state of healthcare professionals and students during the COVID-19 pandemic in Ecuador remains understudied and how to improve their mental health is a challenge.

Objective: This study aimed to explore the anxiety and depressive symptomatology among healthcare students and professionals in Ecuador and to examine the role of psychological inflexibility, loneliness, and psychological stress as predictors of anxiety and depression symptoms.

Methods: A total of 191 undergraduate and graduate healthcare students in clinical practice (early-career healthcare professionals) in Ecuador were surveyed between January and March 2021 using standardized measures of psychological stress (PSS), psychological inflexibility (AAQ), loneliness (UCLA), alcohol consumption (AUDIT-C), and anxiety and depressive symptomatology (PHQ). Macro Process for SPSS (models 4 and 7) were used to test mediation effects.

Results: Alcohol consumption varied between men and women and anxiety and depression symptomatology was generally low among the sample. Psychological inflexibility and loneliness mediated the impact of stress on anxiety and depressive mood in participants, regardless of gender and previous personal history of COVID-19.

Discussion: Implications of psychological inflexibility and the prevention and coping with stress in healthcare professionals during COVID-19 are further discussed.
COVID-19 Critical Care Simulations: An International Cross-Sectional Survey
Authors: Temsah Mohamad-Hani , Alrabiaah Abdulkarim , Al-Eyadhy Ayman , Al-Sohime Fahad , Al Huzaimi Abdullah , Alamro Nurah , Alhasan Khalid , Upadhye Vaibhavi , Jamal Amr , Aljamaan Fadi , Alhaboob Ali , Arabi Yaseen M. , Lazarovici Marc , Somily Ali M. , Boker Abdulaziz M.
Published: September 2021

Objective:To describe the utility and patterns of COVID-19 simulation scenarios across different international healthcare centers.

Methods:This is a cross-sectional, international survey for multiple simulation centers team members, including team-leaders and healthcare workers (HCWs), based on each center's debriefing reports from 30 countries in all WHO regions. The main outcome measures were the COVID-19 simulations characteristics, facilitators, obstacles, and challenges encountered during the simulation sessions.

Results:Invitation was sent to 343 simulation team leaders and multidisciplinary HCWs who responded; 121 completed the survey. The frequency of simulation sessions was monthly (27.1%), weekly (24.8%), twice weekly (19.8%), or daily (21.5%). Regarding the themes of the simulation sessions, they were COVID-19 patient arrival to ER (69.4%), COVID-19 patient intubation due to respiratory failure (66.1%), COVID-19 patient requiring CPR (53.7%), COVID-19 transport inside the hospital (53.7%), COVID-19 elective intubation in OR (37.2%), or Delivery of COVID-19 mother and neonatal care (19%). Among participants, 55.6% reported the team's full engagement in the simulation sessions. The average session length was 30–60 min. The debriefing process was conducted by the ICU facilitator in (51%) of the sessions followed by simulation staff in 41% of the sessions. A total of 80% reported significant improvement in clinical preparedness after simulation sessions, and 70% were satisfied with the COVID-19 sessions. Most perceived issues reported were related to infection control measures, followed by team dynamics, logistics, and patient transport issues.

Conclusion:Simulation centers team leaders and HCWs reported positive feedback on COVID-19 simulation sessions with multidisciplinary personnel involvement. These drills are a valuable tool for rehearsing safe dynamics on the frontline of COVID-19. More research on COVID-19 simulation outcomes is warranted; to explore variable factors for each country and healthcare system.
Characterization of Oral Squamous Cell Carcinoma Associated Inflammation: A Pilot Study
Authors: Laliberté Catherine , Ng Nicole , Eymael Denise , Higgins Kevin , Ali Aiman , Kiss Alex , Bradley Grace , Magalhaes Marco A. O.
Published: September 2021

Background: Oral squamous cell carcinoma (OSCC) is a devastating disease that is usually associated with a dense associated inflammatory infiltrate. Characterizing tumor-associated inflammation is critical to understand the pathogenies of tumor development and progression.

Methods: We have tested a protocol to analyze tissue and salivary immune cells and mediators of 37 patients with OSCC at different stages and compared to eight chronic periodontitis patients and 24 healthy controls. Tissue analysis was based on fluorescent immunohistochemistry (FIHC) and inflammatory mediators were analyzed using a Luminex-based 30-Plex panel. Immune cells were analyzed using multichannel flow cytometry including CD45, CD66b, CD3, CD4, CD8, CD25, CD56, CD68, CD138, PD-1, and PD-L1.

Results: We show an increase in OSCC-associated inflammation characterized by increased pro-inflammatory cytokines including IL-6, IL-8, TNFα, and GMCSF and increased salivary immune cells.

Conclusion: We described a new method to analyze salivary inflammatory markers that can be used in future studies to monitor disease progression and prognosis.
Productivity Hot Spots and Cold Spots: Setting Geographic Priorities for Achieving Food Production Targets
Authors: Mamiit Rusyan Jill , Yanagida John , Miura Tomoaki
Published: September 2021

Rice is the most important staple food in the Philippines as it provides almost half of the calorie requirements of the population. The domestic supply of rice, however, is inadequate to meet local demand, making the Philippines one of the top five rice-importing countries in the world. To close the domestic supply-and-demand gap, agricultural planners and policymakers in the Philippines have been promoting interventions to increase farm-level productivity. In support of the government efforts to increase rice productivity, a stochastic frontier analysis combined with an optimized spatial hot spot analysis was conducted to determine the factors that may influence the increase in rice farm efficiency and also identify candidate areas for relevant geographic-specific rice production interventions. Results show that enhancing access to irrigation and farm inputs and increasing the producers' technical capacity can help address the local supply deficiency by potentially increasing yield per hectare to as high as 5.50 metric tons per hectare. The approach to potentially increase rice farm technical efficiency and productivity must consider the spatial nature of rice production as suggested by the findings from the optimized hot spot analysis. It is important that policy interventions consider areas with a high incidence of low levels of productivity and technical efficiency. These are the locations where agricultural planners and policymakers can make greater impacts on rice yields. Relevant policies and initiatives, therefore, should take into account the geographical location of farms to ensure the greatest contribution to attaining food production targets.
Relevance and Recommendations for the Application of Cardioplegic Solutions in Cardiopulmonary Bypass Surgery in Pigs
Authors: Glöckner Anna , Ossmann Susann , Ginther Andre , Kang Jagdip , Borger Michael A. , Hoyer Alexandro , Dieterlen Maja-Theresa
Published: September 2021

Cardioplegic solutions play a major role in cardiac surgery due to the fact that they create a silent operating field and protect the myocardium against ischemia and reperfusion injury. For studies on cardioplegic solutions, it is important to compare their effects and to have a valid platform for preclinical testing of new cardioplegic solutions and their additives. Due to the strong anatomical and physiological cardiovascular similarities between pigs and humans, porcine models are suitable for investigating the effects of cardioplegic solutions. This review provides an overview of the results of the application of cardioplegic solutions in adult or pediatric pig models over the past 25 years. The advantages, disadvantages, limitations, and refinement strategies of these models are discussed.
Gamification and Control of Nitinol Based Ankle Rehabilitation Robot
Authors: Hau Chong Tune , Gouwanda Darwin , Gopalai Alpha A. , Low Cheng Yee , Hanapiah Fazah A.
Published: September 2021

Conventional ankle rehabilitation exercises can be monotonous and repetitive. The use of robots and games can complement the existing practices, provide an engaging environment for the patient and alleviate the physiotherapist’s workload. This paper presents an ankle rehabilitation robot that uses two nitinol wire actuators and a Pong game to provide foot plantarflexion and dorsiflexion exercises. Nitinol is a type of smart material that has high volumetric mechanical energy density and can produce translational motion. A two-state discrete antagonistic control is proposed to manipulate the actuators. The system was tested on healthy participants and stroke patients. The results showed that the robot was safe and compliant. The robot did not forcefully plantarflex or dorsiflex the foot when the participant exerted opposing force. The actuators worked antagonistically to flex to the foot as intended, in sync with the up and down motions of the player’s bat in the game. These behaviors demonstrated the feasibility of a nitinol-based ankle rehabilitation robot and a simple and yet intuitive game in providing interactive rehabilitation exercise. The robot is expected to enhance the patient’s experience, participation and compliance to the rehabilitation routine and to quantitatively monitor the patient’s recovery progress.
Chronic Stress, Exercise and Cardiovascular Disease: Placing the Benefits and Risks of Physical Activity into Perspective
Authors: Franklin Barry A. , Rusia Akash , Haskin-Popp Cindy , Tawney Adam
Published: September 2021

Chronic stress, which has been exacerbated worldwide by the lingering COVID pandemic, has been strongly linked to cardiovascular disease (CVD). In addition, autonomic dysregulation via sustained sympathetic activity has been shown to increase the risk of arrhythmias, platelet aggregation, acute coronary syndromes and heart failure. Fortunately, effective coping strategies have been shown to attenuate the magnitude of hyperarousal associated with the stress response, including moderate-to-vigorous lifestyle activity and/or structured exercise. A good-to-excellent level of cardiorespiratory fitness also appears to be highly cardioprotective. These beneficial effects have been substantiated by numerous studies that have evaluated the levels of stress reactivity and stress recovery in physically active individuals versus matched sedentary controls, as well as before and after exercise interventions. On the other hand, unaccustomed strenuous exercise in habitually sedentary persons with underlying CVD is associated with a disproportionate incidence of acute cardiac events. Moreover, extreme exercise regimens appear to increase coronary calcification and the likelihood of developing atrial fibrillation. This review summarizes these relations and more, with specific reference to placing the benefits and risks of physical activity into perspective.
How Close Are We toward an Optimal Balance in Safety and Efficacy in Catheter Ablation of Atrial Fibrillation? Lessons from the CLOSE Protocol
Authors: Lycke Michelle , O’Neill Louisa , Gillis Kris , Wielandts Jean-Yves , Le Polain De Waroux Jean-Benoit , Tavernier Rene , Knecht Sebastien , Duytschaever Mattias
Published: September 2021

Catheter ablation for atrial fibrillation (AF) is a common treatment strategy in patients with drug-resistant, symptomatic AF. In patients with paroxysmal and short-standing persistent AF, pulmonary vein isolation (PVI) is often enough to prevent recurrence of atrial tachyarrhythmia (ATA). Point-by-point encircling of the PVs with radiofrequency (RF) applications, together with cryoballoon ablation, have been the mainstay strategies for the last 10 to 20 years. Each of these strategies, however, suffers from the delicate balance between preventing PV reconnection, on the one hand (toward more energy), and preventing (mainly esophageal) complications (toward less energy), on the other. The CLOSE protocol was developed as an RF ablation strategy that would result in the safe creation of durable isolation leading to improved outcomes. Basically, the aim of the protocol is to enclose the pulmonary veins with stable, contiguous (intertag distance, ITD ≤ 6 mm) and optimized lesions (35 Watts, W, RF applications up to ablation index targets of ≥400 and ≥550 at the posterior and anterior wall). In this review, we describe the background of the CLOSE protocol and the studies from the St Jan Bruges research group on procedural performance, efficacy, and safety of the CLOSE protocol in (a) single-center prospective PILOT study (CLOSE-PILOT), (b) a single-center prospective study with continuous rhythm monitoring (CLOSE to CURE), (c) a database of systematic esophageal endoscopic studies, (d) a multicenter prospective study (VISTAX), and (e) the CLOSE database (comprising > 400 patients). We also discuss the results of the randomized POWER-AF study comparing conventional CLOSE to high power CLOSE (up to 50 W). Finally, we discuss the performance, safety, and efficacy of the CLOSE protocol in light of the emerging changes in the field of catheter ablation being ultra-short high-power ablation and electroporation.
Impact of the Kunming–Bangkok Highway on Land Use Changes along the Route between Laos and Thailand
Authors: Zheng Fangyu , Huang Jiuming , Feng Zhiming , Xiao Chiwei
Published: September 2021

Road construction fragments the landscape, reduces connectivity, and drives land use changes. To our knowledge, little is known about the scope and intensity of the effects of cross-border roads on changes in land use. Here, with the land use data products provided by the US Agency for International Development’s SERVIR Mekong project, using the GIS-based spatial analysis to quantitatively analyze and compare the effects of the cross-border road on land use changes within a 30 km buffer area along the Kunming–Bangkok Highway between Laos and Thailand. The results show the following: The greater the distance was from the highway, the smaller were the overall changes in land use within the buffer zone. A comparison of the situation before and after the road was opened in 2013 revealed significant differences in the most influential land use types of agricultural expansion, i.e., from 47.07% to 52.07% (the buffer zone was 1 km). In particular, 57.32% (1381.93 ha) and 40.08% (966.46 ha) of the land occupied by forests had been converted into land for plantation and agriculture, respectively, from 2013 to 2018. The scope of the impact of the operational route on the dynamics of land use was inconsistent. The largest impact before the road became operational was within 4 km of the buffer zone (0.26 to 0.24). Once the road had been opened, the range of its impact was beyond 10 km (0.63 to 0.57). The work here can provide a scientific basis for regional transportation planning and the sustainable use of land resources.
Impact of Neodymium and Scandium Ionic Radii on Sorption Dynamics of Amberlite IR120 and AB-17-8 Remote Interaction
Authors: Jumadilov Talkybek , Totkhuskyzy Bakytgul , Malimbayeva Zamira , Kondaurov Ruslan , Imangazy Aldan , Khimersen Khuangul , Grazulevicius Juozas
Published: September 2021

The aim of the work is to provide a comparative study of influence of ionic radii of neodymium and scandium ions on their sorption process from corresponding sulfates by individual ion exchangers Amberlite IR120, AB-17-8 and interpolymer system Amberlite IR120-AB-17-8. Experiments were carried out by using the following physicochemical methods of analysis: conductometry, pH-metry, colorimetry, and atomic-emission spectroscopy. Ion exchangers in the interpolymer system undergo remote interactions with a further transition into highly ionized state. There is the formation of optimal conformation in the structure of the initial ion exchangers. A significant increase of ionization of the ion-exchange resins occurs at molar ratio of Amberlite IR120:AB-17-8 = 5:1. A significant increase of sorption properties is observed at this ratio due to the mutual activation of ion exchangers. The average growth of sorption properties in interpolymer system Amberlite IR120:AB-17-8 = 5:1 is over 90% comparatively to Amberlite IR120 and almost 170% comparatively to AB-17-8 for neodymium ions sorption; for scandium ions sorption the growth is over 65% comparatively to Amberlite IR120 and almost 90% comparatively to AB-17-8. A possible reason for higher sorption of neodymium ions in comparison with scandium ions is maximum conformity of globes of internode links of Amberlite IR120 and AB-17-8 after activation to sizes of neodymium sulfate in an aqueous medium.
Selective Laser Melting of Hydroxyapatite: Perspectives for 3D Printing of Bioresorbable Ceramic Implants
Authors: Bulina Natalia V. , Baev Sergey G. , Makarova Svetlana V. , Vorobyev Alexander M. , Titkov Alexander I. , Bessmeltsev Victor P. , Lyakhov Nikolay Z.
Published: September 2021

Hydroxyapatite, being the major mineral component of tooth enamel and natural bones, is a good candidate for bone tissue engineering applications. One of the promising approaches for manufacturing of three-dimensional objects is selective laser sintering/melting which enables the creation of a dense structure directly during 3D printing by adding material layer-by-layer. The effect of laser irradiation with a wavelength of 10.6 μm on the behavior of mechanochemically synthesized hydroxyapatite under different treatment conditions was studied for the first time in this work. It was shown that, in contrast to laser treatment, the congruent melting is impossible under conditions of a relatively slow rate of heating in a furnace. Depending on the mode of laser treatment, hydroxyapatite can be sintered or melted, or partially decomposed into the more resorbable calcium phosphates. It was found that the congruent selective laser melting of hydroxyapatite can be achieved by treating the dense powder layer with a 0.2 mm laser spot at a power of 4 W and at a scanning speed of 700 mm/s. Melting was shown to be accompanied by the crystallization of a dense monolayer of oxyhydroxyapatite while preserving the initial apatite crystal lattice. The thickness of the melted layer, the presence of micron-sized pores, and the phase composition can be controlled by varying the scanning speed and laser power. This set of parameters permits the use of selective laser melting technology for the production of oxyhydroxyapatite biodegradable implants with acceptable properties by 3D printing.
On the Tribological and Oxidation Study of Xanthophylls as Natural Additives in Castor Oil for Green Lubrication
Authors: Moreno Karla J. , Hernández-Sierra María Teresa , Báez José E. , Rodríguez-deLeón Eloy , Aguilera-Camacho Luis Daniel , García-Miranda J. Santos
Published: September 2021

The present study focuses on an introductory analysis of the use of three xanthophylls as additives for green lubricant applications. For this purpose, the additives were characterized by FTIR and 1H-NMR techniques, and the bio-lubricants were described by their physical properties. The effect of the natural compounds on the friction and wear properties of bio-lubricants were evaluated by sliding friction tests under boundary conditions, as confirmed by an analysis of the lubricating film thickness. The antioxidant capacity was analyzed by FTIR spectroscopy. It was observed better wear protection in castor oil with xanthophylls than without these additives. The wear rate was reduced up to 50% compared with neat oil. Lesser beneficial effects were appreciated in friction coefficient since it was increased 25%. The best contribution was observed with astaxanthin as an additive. In addition, a significant improvement in the oxidation of castor oil, complemented with this additive, was exhibited by FTIR analysis. It was found that xanthophylls could be employed as additives for totally biodegradable lubricant applications since they have better tribological and antioxidant behavior than current additives.
Preparation and Properties of Fractionated Soybean Protein Isolate Films
Authors: Wei Yunxiao , Huang Ze’en , Yu Zuolong , Han Chao , Yang Cairong
Published: September 2021

Soybean protein isolate (SPI) and its four fractionated products (7S globulin, 11S globulin, upper soybean residue, and lower soybean residue) were compared by fabricating films and film liquids. The separation and grading effects, rheological properties of the film liquids, and difficulty in uncovering the films, in addition to the mechanical properties, water vapor permeability, oil permeability, and surface morphology of the films, were investigated. Results showed that the centrifugal precipitation method could be used to produce fractionated products. The 7S and 11S globulin films exhibited better hydrogels at lower shear rates than the other SPIs; however, they were more difficult to uncover. The tensile strength of the graded films decreased by varying degrees. However, the elongation at the break of the upper soybean residue film considerably increased, reaching 70.47%. Moreover, the permeability and surface morphology of the film were enhanced or weakened. The fractionated products, 7S and 11S globulin films, exhibited better performance. Overall, this study provides a basis for the improved development and use of fractioned SPI products.
CONFESIÓN ESPONTÁNEA EN EL EMPLAZAMIENTO EN MATERIA CIVIL
Authors: Rodríguez-García Ivette Delfina
Published: September 2021

En materia civil hay que considerar la prueba como acción de evidenciar un derecho o hecho de acuerdo a los medios establecidos, es demostrar la verdad o falsedad, la cual se equipara a la existencia o inexistencia de algo. En ese sentido, la confesión espontánea en el emplazamiento, aborda de manera deductiva una descripción de precepto legal dentro del marco doctrinal y normativo que existe al respecto a través, de un proceso teórico metodológico que detalla los elementos de emplazamiento, prueba y confesión.
MEDIOS DE COMUNICACIÓN Y CULTURA DE PAZ PARA LA CONVIVENCIA DEMOCRÁTICA
Authors: Hernández-Milla Ana Julia
Published: September 2021

El desarrollo de las sociedades dentro de un orden establecido considera una cultura basada en las normas y obligaciones competentes al ciudadano, estructuras sociales e instituciones del sistema de justicia. En ese sentido, potencializar los medios de comunicación para asegurar una sociedad con cultura de paz reflejada en una convivencia democrática, involucra a diversos actores con un fin de bien común, que de forma directa e indirecta beneficie a otros sectores o ámbitos de la población e instituciones. Este documento pretende dar un panorama de lo benéfico que resulta socializar, interactuar e innovar mecanismos de acción que preponderen a una sociedad sostenible, democrática e integral, basada en la participación, pluralidad, tolerancia y respeto, teniendo como finalidad realizar reflexiones sobre la importancia de la implementación  de la cultura de paz como mecanismo que permita favorecer y promover valores cívicos y sociales, en la construcción de una eficaz convivencia democrática y por ende la prevención de la violencia, incluida la política, y el rol importante que tienen los medios de comunicación, como ente de procesamiento de información oportuna a la ciudadanía, que muchas veces sobrepasan la intención de informar, para influir en las simpatías o ánimos, “contrario sensu”, confrontando a actores políticos y sus simpatizantes.
LA SUSPENSIÓN DEL ACTO RECLAMADO A “CONTRARIO SENSU” DEL JUICIO DE AMPARO
Authors: Rosiles-Sánchez José Refugio
Published: September 2021

Este documento expone la suspensión del acto reclamado como la Institución Procesal que es, su importancia y trascendencia, cuya finalidad es mantener viva la materia que da origen al Juicio de Amparo, congelando el actuar de la Autoridad, asegurando que la protección Constitucional se logre. Esta figura permite al Juzgador mantener las cosas en el estado en el que se encuentran, mediante la vía incidental; limitando con ello el actuar de las autoridades para garantizar la protección de los derechos humanos. ¿Qué pasa cuando el dejar de hacer de la Autoridad pone en peligro la materia del Amparo? En ese sentido, se documenta el caso de un hombre de la tercera edad que vive en condiciones muy precarias de pobreza y marginación a quien le fue concedida una suspensión a contrario sensu para que la autoridad responsable le proporcionara los servicios médicos necesarios. Se describen los supuestos en los que el Juez de Amparo dicta medidas de conservación y ordena a las autoridades continuar con el ejercicio de sus facultades jurisdiccionales con el fin de lograr la protección más amplia de los derechos humanos.
MEDIACIÓN ESCOLAR: EN EL NIVEL MEDIO SUPERIOR
Authors: Castillo-Torres Álvaro Pastor
Published: September 2021

El sistema educativo nacional en México contempla la educación básica, la educación media superior y la educación superior. El tema de interés en este documento es la importancia de la mediación escolar en el nivel medio superior conocido como bachillerato o preparatoria, este nivel prepara y forma a jóvenes estudiantes para el ingreso a la educación superior o universitaria. En ese tenor de formación a los estudiantes, es pertinente socializar las herramientas y técnicas de los mecanismos alternativos para la gestión y solución de conflictos en pro de una cultura de paz. La mediación escolar coadyuva al sistema educativo en la formación del estudiante toda vez que es una persona que está transitando a una edad adulta en el que adquiere mayor número de responsabilidades. Este tipo de mediación otorga a la comunidad estudiantil potencializar los espacios de convivencia reforzando el diálogo y comunicación con participación activa, plural y respeto.
PRINCIPIO PRO PERSONA EN EL PROCESO FAMILIAR
Authors: Contreras-Sánchez Fermín
Published: September 2021

Este artículo se funda en el análisis de la omisión de aplicar el principio pro persona en los procesos familiares en Tabasco, en particular en los Juicios donde tienen intervención menores de edad, ya sea Guarda y Custodia, Controversia Familiar, Alimentos, Divorcios, Filiaciones, Paternidad en reconocimiento como en desconocimiento, entre otros, siendo éste un Derecho Humano (DH) consagrado en el artículo 1º de la Constitución Política de los Estados Unidos Mexicanos (CPEUM) y en diversos Tratados Internacionales, Sentencias emitidas por los organismos internacionales, así como múltiples criterios jurisprudenciales pronunciados por nuestra Suprema Corte de Justicia de la Nación (SCJN). En el Estado de Tabasco, ante la problemática que se presenta en el núcleo familiar, por las constantes demandas que a diario se registran en los diversos Juzgados Familiares y Civiles, como es el caso de los Juicios de orden familiar antes citado, se hace necesario que los Jueces Familiares y Civiles, se obliguen a aplicar el principio pro persona y el principio pro niño o el interés superior de niñas, niños y adolescentes. Estos principios consisten en  aplicar, en el sentido más amplio lo más benéfico a un menor de edad, en todo juicio en donde se encuentre involucrado, por lo que el juez en el caso concreto de la guarda y custodia  al radicar o dar inicio a la demanda, debe decretar de oficio la convivencia provisional, escucha de menores de manera urgente, aunque las partes no lo soliciten ; escenario que actualmente los Jueces tanto Familiar y cómo Civil en nuestra entidad, no respetan ni aplican, siendo un derecho humano consagrado en los artículos 1º  párrafo segundo y 4º  párrafos noveno y décimo de nuestra  Constitución.
SUSTITUCIÓN DEL FISCAL EN EL SISTEMA ACUSATORIO
Authors: Zavaleta-De-Los-Santos Roberto Ulises
Published: September 2021

La impunidad y corrupción son flagelos siempre presentes en la impartición de justicia. La falta de capacidad técnica del fiscal en las audiencias preliminares y de juicio, genera en muchos casos impunidad y en otros casos es generada por la corrupción. El presente artículo aborda este tema, a través de un método de casos que tiene como actividad central el análisis de dicha problemática presente en las audiencias. La finalidad es darle sentido a la norma constitucional federal cuando establece en su fracción I, apartado A, del artículo 20, “el proceso penal tendrá por objeto el esclarecimiento de los hechos, proteger al inocente, procurar que el culpable no quede impune”. El análisis surge desde la práctica profesional, la hipótesis consiste en sostener la necesidad de justificar la sustitución del fiscal en el sistema penal acusatorio en México a través de los principios del propio sistema. La figura del fiscal como órgano técnico debe ser abordada, para lo cual es necesario exponer mecanismos, que permitan al juez esa sustitución entre tanto se establece en la norma de manera explícita.
Silene aminiradii (Caryophyllaceae), an Interesting Alpine Plant in Iran
Authors: Gholipour Abbas
Published: September 2021

Botanical explorations in the alpine zone of the Shahvar and Shah Kouh Mountains from Semnan and Golestan Provinces (northeastern Iran) led to the collection of interesting specimens of the genus Silene L. (Caryophyllaceae). Taxonomic study of these plants and comparison with determined plant specimens showed that the specimens belong to an unknown species. I describe it as S. aminiradii Gholipour, belonging to section Auriculatae (Boiss.) Schischk. from northeastern Iran. The new species is compared with S. lucida Chowdhuri and S. crispans Litv. as the most similar species. Silene aminiradii is a caespitose perennial alpine gynodioecious plant with prostrate stems covered with dense, retrorsely simple hairs. The distribution, ecological features, reproductive phenology, and photos of S. aminiradii are presented.
MENGUNGKAP MOTIVASI SULTAN HAMENGKU BUWONO IX MEMBANGUN SELOKAN MATARAM
Authors: Yuana Tri Utomo
Published: September 2021

Abstrak

Abstrak: Mengungkap Motivasi Sultan Hamengku Buwono IX Membangun Selokan Mataram. Tujuan penelitian untuk mengetahui motivasi Sultan Hamengku Buwono IX membangun Selokan Mataram. Metode penelitian yang digunakan bersifat kualitatif dengan sumber data dari beberapa artikel dan literatur. Data dianalisis dengan pendekatan sejarah menggunakan metode interpretasi. Hasil penelitian menunjukkan bahwa ada tiga motivasi Sultan HB IX, yaitu kebijakan filosofis, ekonomis, dan nasionalisme. Motivasi filosofisnya adalah berasal dari ajaran Sunan Kalijaga bahwa kasultanan Yogyakarta bisa makmur jika dua sungai yang mengapit Yogyakarta dipertemukan dalam satu aliran. Motivasi ekonominya berhubungan dengan cara pandang penguasa dalam menyejahterakan petani untuk irigasi sawah. Pembangunan Selokan Mataram merupakan cermin nasionalisme Sultan dalam membela rakyat dari tuntutan Rhomusa Jepang.

 

Abstract

The purpose of the study was to determine the motivation of Sultan Hamengku Buwono IX to build the Mataram Sewer. The research method used is qualitative with data sources from several articles and literature. Data were analyzed by historical approach using interpretation method. The results showed that the three motivations of Sultan HB IX, namely philosophical policy, economics, and nationalism. The philosophical motivation is derived from the teachings of Sunan Kalijaga that the Sultanate of Yogyakarta can prosper if the two rivers flanking Yogyakarta are brought together in one stream. The economic motivation is related to the perspective of the authorities in the welfare of farmers for irrigating rice fields. The construction of the Mataram Sewer is a reflection of the Sultan's nationalism in defending the people from the demands of the Japanese Rhomusa.
Sangam Literary Short Poems - Ethnographic Perspective
Authors: M Sankar
Published: September 2021

Anthropology is the science of being able to talk about man. There are various disciplines in anthropology. Cultural anthropology is one of them. There are two divisions in this cultural anthropology. One of them is ethnography; The other is Ethnology. Of these, ethnographic research appeared in the early 19th century. Ethnography is the study of all kinds of traditions found in a particular group of people or in a particular area. Those who write this will be called "ethnographers". Ethnography is the study of how a person of a particular culture views his or her culture from that perspective.  Today, they are writing about the culture of their people. This is what we call "Tinaisar inavariviyal". Cultural studies also form the basis of ethnographic research. Ethnographic research is helpful in examining the culture of a particular ethnic group. That is why ethnographic research may have laid its scepter in the fields of social anthropology, cultural anthropology and folklore. In Short Ethnography is the process of penetrating the life of a particular ethnic group.  In this way one can understand the Civilization and Culture. As we seek to explain a particular group and their culture, we begin to act with certain elements in mind. In that sense Bhagwatsala Bharathi exemplifies 37 elements of ethnography in his Cultural Anthropology. These elements contribute to penetrating the lives of a particular ethnic group. In this way one can understand the civilization and culture of the Peoples. Kuṟiñcittiṇai is one of the four geographical categories referred to as Tolkappiyam. There are 488 poems about in the Sangam literature. The purpose of this article is to evaluate these collections on the basis of Ethnographical Study, with a collection of Sangam literary Kuṟiñcittiṇai Poems.  It explores the Material, Cultural, Occupations, Rituals, and Beliefs of the people of Kurinji.