bluuebunny/crossref_metadata_2025 huggingface dataset:
Phase space description of the dynamics due to the coupled effect of the planetary oblateness and the solar radiation pressure perturbations
Authors: Alessi Elisa Maria , Colombo Camilla , Rossi Alessandro
Published: September 2019

The aim of this work is to provide an analytical model to characterize the equilibrium points and the phase space associated with the singly averaged dynamics caused by the planetary oblateness coupled with the solar radiation pressure perturbations. A two-dimensional differential system is derived by considering the classical theory, supported by the existence of an integral of motion comprising semi-major axis, eccentricity and inclination. Under the single resonance hypothesis, the analytical expressions for the equilibrium points in the eccentricity-resonant angle space are provided, together with the corresponding linear stability. The Hamiltonian formulation is also given. The model is applied considering, as example, the Earth as major oblate body, and a simple tool to visualize the structure of the phase space is presented. Finally, some considerations on the possible use and development of the proposed model are drawn.
The potential of magnetisation transfer NMR to monitor the dissolution process of cellulose in cold alkali
Authors: Gunnarsson Maria , Hasani Merima , Bernin Diana
Published: September 2019

Cellulose is the most important biopolymer on earth and, when derived from e.g. wood, a promising alternative to for example cotton, which exhibits a large environmental burden. The replacement depends, however, on an efficient dissolution process of cellulose. Cold aqueous alkali systems are attractive but these solvents have peculiarities, which might be overcome by understanding the acting mechanisms. Proposed dissolution mechanisms are for example the breakage of hydrophobic interactions and partly deprotonation of the cellulose hydroxyl groups. Here, we performed a mechanistic study using equimolar aqueous solutions of LiOH, NaOH and KOH to elucidate the dissolution process of microcrystalline cellulose (MCC). The pH was the highest for KOH(aq) followed by NaOH(aq) and LiOH(aq). We used a combination of conventional and advanced solution-state NMR methods to monitor the dissolution process of MCC by solely increasing the temperature from − 10 to 5 °C. KOH(aq) dissolved roughly 25% of the maximum amount of MCC while NaOH(aq) and LiOH(aq) dissolved up to 70%. Water motions on nanoscale timescales present in non-frozen water, remained unaffected on the addition of MCC. Magnetisation transfer (MT) NMR experiments monitored the semi-rigid MCC as a function of temperature. Interestingly, although NaOH(aq) and LiOH(aq) were able to dissolve a similar amount at 5 °C, MT spectra revealed differences with increasing temperature, suggesting a difference in the swollen state of MCC in LiOH(aq) already at − 10 °C. Furthermore, MT NMR shows a great potential to study the water exchange dynamics with the swollen and semi-rigid MCC fraction in these systems, which might give valuable insights into the dissolution mechanism in cold alkali.
A modified ionic liquid clay to remove heavy metals from water: investigating its catalytic activity
Authors: Kakaei S. , Khameneh E. S. , Hosseini M. H. , Moharreri M. M.
Published: September 2019

The new clay modified with triazole and triazolium ligands was prepared in this research. These materials were applied as abundant and eco-friendly adsorbents for removal of heavy metal ions such as Pb(II), Co(II) and Zn(II) ions. The adsorption efficiency of these materials was calculated by relevant equations such as Langmuir and Freundlich as well as kinetic studies with pseudo-first-order and pseudo-second-order models. These adsorbents proved to be very active on heavy metal ion adsorption. The characterization of these new materials was carried out by various techniques such as X-ray diffraction, thermogravimetric analysis, scanning electron microscope (SEM), X-ray photoelectron spectroscopy and energy-dispersive X-ray spectroscopy as well as SEM-map analysis. Eventually, the catalytic activity of the adsorbents which treated with heavy metal ion solutions was studied in the reduction of nitroarenes to its corresponding amines. The prepared adsorbent–catalyst materials indicated efficient catalytic activity in the reduction of nitroarenes to amines in ambient conditions.

Graphic abstract
Colorectal Cancer Outcomes in a Large Negative Computed Tomography Colonography Screening Cohort
Authors: McComiskey David A. , Barrett Brendan , Flemming Jeffrey , McKay Kathy , Sala Eric
Published: September 2019

Introduction

At our institution, the most common cohort of individuals having computed tomography colonography (CTC) are those that require primary screening for colorectal cancer and were unable to tolerate or failed optical colonoscopy (OC). CTC is an efficient method for detecting polyps, masses, flat-lesions, and overt colorectal cancer, serving as a viable alternative to colonoscopy. This study follows patients with negative CTC results to evaluate the number of clinically significant lesions that may have been potentially missed by CTC. We suspect this number will be exceedingly low given the high sensitivity of this technique.

Methods

All patients with negative CTC screening (n = 509) in the Eastern Health Medical Health Region, located in Newfoundland and Labrador, Canada were included. An electronic medical record review was undertaken, encompassing provider, colonoscopy, imaging, and histopathology reports. Subjects were also checked through the Newfoundland Cancer Clinic Registry Database. All incidents of colorectal cancer were recorded.

Results

The study cohort comprised 509 subjects. These subjects were followed for an average of 7.88 years. Two colorectal adenocarcinomas in this cohort were identified representing a crude cancer incidence rate of 0.49 cancers per 1000 patient years, and a rate of 0.39% following a normal CTC.

Conclusions

Colorectal cancer presenting clinically is rare in the 7.88 years following a negative CTC, suggesting CTC is equally effective for colorectal screening compared to OC. Furthermore, current guidelines that recommend interval CTC screening every 5 years is conservative, and interval screening can likely be recommended over a longer time frame.
Public feedback on a proposed statewide virtual translational research community
Authors: Eder Milton (Mickey) , Patten Christi A. , Brockman Tabetha A. , Hendricks Deborah , Valdez-Soto Miguel , Zavala-Rocha Maria , Amelang Miriam , Wi Chung , Major-Elechi Brittny , Balls-Berry Joyce (Joy) E.
Published: September 2019

Introduction:

Researchers have explored using the internet and social media to recruit participants to specific research projects. Less systematic work has been done to inform the engagement of large populations in virtual communities to advance clinical and translational science. We report on our first step to use social media to engage Minnesota residents by studying the willingness of participants to engage in a virtual (Facebook) community about the concepts of health and health-related research.

Methods:

Data were collected at the 2018 Minnesota State Fair using a cross-sectional, 46-item survey with assessment including sociodemographics and willingness to engage in a Facebook group for health-related research. Quantitative analysis included univariate, bivariate, and multivariate analyses. Content analysis was used to generate themes from open-ended survey responses.

Results:

Five hundred people completed the survey; after data cleaning, 418 participant responses informed this report. A majority were younger than age 50 (73%), female (66%), and married/partnered (54%). Overall, 46% of participants agreed/strongly agreed they are willing to join the Facebook group. Multivariate logistic regression identified social media use over the past 6 months as the sole variable independently associated with willingness to join the Facebook group (once a day vs. never or rarely OR = 1.82 (0.86, 3.88), several hours a day vs. never or rarely OR = 2.17 (1.17, 4.02, overall p-value 0.048).

Conclusion:

Facebook holds potential for reaching a broader community, democratizing access to and engagement with clinical and translational research. Social media infrastructure and content could be disseminated to other institutions with Clinical and Translational Science Awards.
A playmaker and moderator: Lord Reid and the framing of the Malayan federal constitution
Authors: Fernando Joseph M.
Published: September 2019

Lord Reid played a vital role as chairman in a Commonwealth commission in framing the Malayan Independence constitution between 1956 and 1957. The Scottish Lord of Appeal sought to ensure the commission's impartiality and to achieve a fair balance between the demands of the various interest groups. The Federation of Malaya was a complex emerging nation-state with a diverse population and the framers had to manage competing interests and demands. This article, through a close examination of the primary constitutional documents, considers Reid's influence on the framing of the Malayan (and hence, Malaysian) federal constitution. The article begins with a brief discussion of Lord Reid's appointment to head the commission and then considers in some depth areas where his influence on the framing of the draft constitution is evident. The article argues that Reid was the main playmaker and moderator during the constitution-framing process and played a critical role in ensuring a balance was achieved between the competing demands of the federal government and the states, safeguarding the fundamental rights of the citizens against the state, and in moderating the various communal demands.
Gotong royong as social citizenship in Indonesia, 1940s to 1990s
Authors: Suwignyo Agus
Published: September 2019

This article examines gotong royong as social citizenship in the second half of the twentieth century in Indonesia. Gotong royong was traditionally understood as a collective spirit among neighbours to strengthen economic and social resilience. However, the institutionalisation of the system through massive development programmes since the 1940s has influenced the common people's perception and practice of it. This article argues that the co-option of gotong royong as part of the discourse of nation-state building transformed the popular view of labour and capital mobilisation from an openly critical stance to apparent submission. Gotong royong became a means of social engineering and an ingenious linguistic strategy by which state elites orchestrated control over the making of citizens. Still, Indonesians have remained vigilant of their participation in gotong royong, and about the potential for its misuse by corrupt officials.
Zubin Kanga: Silver Screens / Steel Strings, London, City, University of London, 26 March 2019
Authors: Erwin Max
Published: September 2019

Zubin Kanga has about as wide a range of performance experience as one can get playing recently written art music – his bio mentions collaborations with contemporary warhorses like Thomas Adès, George Benjamin, and Steve Reich – but as a solo performer he has cultivated a distinctive and specialised practice that maps onto the wider action of international New Music in increasingly fascinating ways. For the past few years, his solo tours have showcased an expanded practice which binds the performer to one or another technological apparatus that centrally determines the form and execution of the piece, raising questions of autonomy, authorship and identity. These concerns are reflected in the titles of the tours: ‘Dark Twin’, ‘Cyborg Pianist’ and, currently, ‘Piano Ex Machina’.
Cognitive gadgets and genetic accommodation
Authors: Jablonka Eva , Ginsburg Simona , Dor Daniel
Published: September 2019

Heyes argues that human metacognitive strategies (cognitive gadgets) evolved through cultural rather than genetic evolution. Although we agree that increased plasticity is the hallmark of human metacognition, we suggest cognitive malleability required the genetic accommodation of gadget-specific processes that enhanced the overall cognitive flexibility of humans.
Executive functions are cognitive gadgets
Authors: Braem Senne , Hommel Bernhard
Published: September 2019

Many psychologists and neuroscientists still see executive functions as independent, domain-general, supervisory functions that are often dissociated from more “low-level” associative learning. Here, we suggest that executive functions very much build on associative learning, and argue that executive functions might be better understood as culture-sensitive cognitive gadgets, rather than as ready-made cognitive instincts.
Report on the To.Sca.Lake 3.0 summer school, total scattering analysis for nanoscience on the Como Lake
Authors: Bertolotti Federica , Ferri Fabio , Masciocchi Norberto , Guagliardi Antonietta
Published: September 2019

The third edition of the To.Sca.Lake Summer School, co-sponsored by ICDD, was organized on the Como Lake shore in Northern Italy, and has seen the participation of more than 50 attendees from four different continents. The main topic was Total Scattering Analysis in the real and reciprocal spaces (by the Pair Distribution Function and the Debye Scattering Equation approaches, respectively). with additional contributions on Small Angle X-ray Scattering and Light Scattering methods, the latter proposed in the static and dynamic modes.
Impact of neighbourhood food environment on diet and obesity in China: a systematic review
Authors: An Ruopeng , He Li , Shen MS Jing
Published: September 2019

Objective:

This study systematically reviewed literature on the neighbourhood food environment in relation to diet and obesity among residents in China.

Design:

A keyword search of peer-reviewed articles was performed in Cochrane Library, PubMed, and Web of Science. Eligibility criteria include study designs: longitudinal/cohort studies or cross-sectional studies; study participants: people of all ages; exposures: neighbourhood food environment (e.g. restaurants, supermarkets, wet markets, fast-food restaurants, or convenience stores); outcomes: diet and/or body weight status; and country: China.

Results:

Seventeen studies met all criteria and were included. Among the eight studies that assessed the neighbourhood food environment in relation to diet, six reported at least one statistically significant relationship in the expected direction, whereas the remaining two exclusively reported null effects. Among the eleven studies that assessed the neighbourhood food environment in relation to body weight or overweight/obesity, ten reported a significant association whereas the remaining one reported a null relationship. Variety, density, and proximity of food outlets were positively associated with local residents’ dietary diversity, portion size, and daily caloric intake. Density and proximity of fast-food restaurants and convenience stores were positively associated with local residents’ adiposity in some but not all studies. Evidence linking any specific food outlet type to diet/obesity remains lacking due to the small number of studies and heterogeneities in food environment measures, geographical locations, and population subgroups.

Conclusions:

The neighbourhood food environment may influence diet and obesity among Chinese residents but the evidence remains preliminary. Future studies adopting an experimental study design and objective/validated environment and dietary measures are warranted.
The attitudes of homeless women in London towards contraception
Authors: Shah Pooja , Koch Tamar , Singh Surinder
Published: September 2019

Aim:

To gain a clearer understanding of the attitudes of homeless women towards contraception in central London.

Background:

Homeless women are more vulnerable to sexually transmitted infections and unwanted pregnancies. This makes it imperative to address the health needs of this population. Evidence regarding the obstacles homeless women face when using contraception and accessing sexual/reproductive care is sparse, and almost non-existent in the United Kingdom (UK). American research has identified past experiences of women suffering side effects and their fear of serious health risks as deterrents of sustained contraceptive use among this population.

Method:

This study used convenience sampling and semi-structured face-to-face interviews. During the interview, a topic guide was used to ensure data relevant to the study aim were being collected. In total, 14 English-speaking women, previously street homeless and/or living in temporary accommodation from two homeless shelters located in central London, were interviewed.

Findings:

In summary, the results suggest this group of study respondents find ongoing access to advice on contraception services difficult largely because of their homelessness. This pre-eminent factor alongside their vulnerability inevitably means that other issues take precedence on a daily basis. Furthermore, issues such as individual choice of contraception and the perceptions of this group of women to health professionals ultimately determine whether women receive the services they need. Bearing in mind the paucity of studies in this area of homelessness, the results point to the need for more research and to the allied question ‘how is it best to provide contraceptive services to those women who find themselves homeless?’
Extractive institutions? Investor returns to Indian railway companies in the age of high imperialism
Authors: Bogart Dan , Chaudhary Latika
Published: September 2019

Did colonial policies in India deliver excessive returns to British investors? We answer this question using annual data on Indian securities trading on the London Stock Exchange. We present new series on market capitalization, capital gains, dividend yields, and total returns of railway securities from 1880 to 1929. The average annual total return on the largest and most important Indian railway securities was 3.7%. These returns were not excessive by any financial standard. Indeed, they were lower than the return on railway securities in North America, Latin America, and Asia. We also undertake an event study analysis to assess whether Indian railways significantly benefited British investors. When the Government of India purchased large positions in the private railway companies between 1880 and 1910, there were opportunities for profit making. However, we find no evidence of abnormal investor returns in the years leading to the purchase of railway companies. Broadly our findings call into question the extractive nature of colonial railway policy.
CARE UP! – Ein Projekt im Namen des Imagewandels des Pflegeberufes
Authors: Leyh Tahnee
Published: September 2019

Zusammenfassung. An der Evangelischen Hochschule Berlin entstand 2018 unter Studierenden des Bachelor of Nursing die Idee einer „Care Up! – Summerschool“ als Initialprojekt im Namen des Imagewandels des Pflegeberufs. Auszubildende, Studierende und Interessierte verschiedener Berliner Gesundheits- und Krankenpflegeschulen entwickelten so vielseitige und bewegende Projektideen, dass sich ein Verein gründete. Wie dieser sich konzipiert, welche Hürden der Spagat zwischen Ausbildung und Studium mit sich bringt und was perspektivisch in Aussicht steht, beschreibt der folgende Artikel.
Studiengangsübergreifendes Lernen im SimLab
Authors: Kerres Andrea , Hausen Anita , Wissing Christiane , Kemser Johannes
Published: September 2019

Zusammenfassung. Die Methode der Simulation bietet Lernenden die Möglichkeit ein planmäßiges Vorgehen in einem geschützten Rahmen, durchdacht und schrittweise für eine beruflich relevante Situation auszuprobieren. Dabei lernen sie, sowohl die Vorgehensweise zielführend einzusetzen als dabei auch eigene Erfahrung durch die Handlungsform zu reflektieren und somit professionelle Kompetenzen weiter zu entwickeln. Wie kann dieser hohe Anspruch annäherungsweise erreicht werden? Überlegungen hierzu und Schritte zur Realisierung werden im Folgenden dargestellt.
Beeindruckende Veranstaltung
Authors: Müller Christoph
Published: September 2019

Zusammenfassung. Die trialogisch veranstalteten Psychose-Seminare bieten Betroffenen, deren Angehörigen, aber auch psychiatrisch Tätigen, essenzielle Themen psychiatrischer Begleitung miteinander zu diskutieren. Im Jahre 2019 werden die Psychose-Seminare 30 Jahre alt. Ich bin einmal ins Feld eingetaucht, um einen psychiatrisch-pflegerischen Blick zu wagen. Die Sichtweisen eines Betroffenen und von Angehörigen werden folgen.
Handlungsfähigkeit in einer komplexen Welt
Authors: Fraunhofer Andreas
Published: September 2019

Zusammenfassung. Die Anforderungen an die Pflegenden werden immer komplexer. Unter anderem diese Entwicklung legitimiert nicht nur, sondern fordert eine grundständige Akademisierung der Pflege ein. Dabei stellt sich allerdings die Frage, wie Studierende, die an den Hochschulen Inhalte meist nur theoretisch gelehrt bekommen, diese strukturiert in der Praxis umsetzen können. Diese Herausforderung zeigt sich schon jetzt im Bereich der Dualen Ausbildung. Dort entziehen sich die hochschulischen Inhalte meist schon allein wegen eines Mangels an akademisierten Praxisanleiter_innen der strukturierten Anleitung. Um dieser Situation auch zukünftig adäquat begegnen zu können, wird das kbo Isar-Amper-Klinikum (kbo-IAK) in Kooperation mit der Hochschule München das erste akademische Lehrkrankenhaus für Pflegewissenschaft Bayerns.
Der Trialog im gesellschaftlichen Wandel
Authors: Bremer Fritz , Zechert Christian
Published: September 2019

Zusammenfassung. Wie eng gesellschaftliche Entwicklungen und psychiatrische Reformen beieinander liegen, zeigt dieser Beitrag zur „Erfindung“ des Trialogs. Dessen sozialwissenschaftliche Grundlagen lassen sich in der von Jürgen Habermas 1981 veröffentlichten „Theorie des kommunikativen Handelns“ identifizieren. Nach 30 Jahren Trialog zeigt sich, auch er muss sich wandeln – weg von der scheinbar klaren Trennung von Psychiatrieerfahrenen, Angehörigen und Professionellen hin zur Wahrnehmung, dass viele Menschen in ihrem Leben zwei, wenn nicht gar drei Rollen einnehmen. Es fällt den Professionellen besonders schwer dies einzugestehen. Dass der folgende Beitrag nahezu zeitgleich mit dem 90. Geburtstag von Jürgen Habermas erscheint, ist ein glücklicher Zufall.
Contemporary Classifications of Suicidal Behaviors
Authors: Goodfellow Benjamin , Kõlves Kairi , De Leo Diego
Published: September 2019

Abstract. Background: The absence of agreed-upon terminology, definitions, and operational classifications has hampered research in the field of suicidology for many decades. Aims and Method: We systematically reviewed contemporary classifications of suicidal behavior using the scope of the classification (comprehensive vs. restricted or single behaviors), and the presence or absence of a classification scheme and an operational definition of intent as features to enable analysis and comparison. Results: A chronological perspective shows that classification systems tend to be more and more precise and operational for clinical and research field work. However, on an international level, the development of classifications appears to precede the establishment of agreed-upon definitions and terms to describe suicidal behavior. Limitations: The review was conducted in English only. Conclusion: Universal agreement on definitions and terms for suicidal behavior should precede the development of classifications.
Differences in the Body Images of Blind and Sighted	Women
Authors: Gebauer Carolin , Guenther Verena , Stuerz Kristina
Published: September 2019

Abstract. This study addresses aspects of body image in blind versus seeing women. Eighty-nine congenitally blinded and 153 sighted women completed questionnaires to demographic, health-relevant data, and body image. The two groups did not differ significantly with regard to demographic and health-relevant data. However, significantly more women have children among the sighted group. All women generally presented as clinically inconspicuous in all factors of the body image. A group comparison does not reveal differences with regard to physical contact, vitality, and self-exaltation. However, a significantly lower sexual fulfillment among the blind persons in comparison to the seeing persons, but a significantly higher self-acceptance, is demonstrated. The results are discussed in the context of the previous scarce findings with regard to body image disorders in blind women and finally questioned whether they could benefit the therapy of body scheme disorders in seeing women.
AGU and Eos are “Covering Climate Now”
Authors: Goss Heather , Bompey Nanci
Published: September 2019

We’re joining with over 200 other news outlets and organizations in a weeklong initiative to prove the power of journalism in telling “the defining story of our time.”
Quantifying the Cloud Particle‐Size Feedback in an Earth System Model
Authors: Zhu Jiang , Poulsen Christopher J.
Published: September 2019

Physical process‐based two‐moment cloud microphysical parameterizations, in which effective cloud particle size evolves prognostically with climate change, have recently been incorporated into global climate models. The impacts of cloud particle‐size change on the cloud feedback, however, have never been explicitly quantified. Here we develop a partial radiative perturbation‐based method to estimate the cloud feedback associated with particle‐size changes in the Community Earth System Model. We find an increase of cloud particle size in the upper troposphere in response to an instantaneous doubling of atmospheric CO2. The associated net, shortwave, and longwave cloud feedbacks are estimated to be 0.18, 0.33, and −0.15 Wm−2 K−1, respectively. The cloud particle‐size feedback is dominated by its shortwave component with a maximum greater than 1.0 Wm−2 K−1 in the tropics and the Southern Ocean. We suggest that the cloud particle‐size feedback is an underappreciated contributor to the spread of cloud feedback and climate sensitivity among current models.
Investigating Fine‐Scale Permeability Structure and Its Control on Hydrothermal Activity Along a Fast‐Spreading Ridge (the East Pacific Rise, 9°43′–53′N) Using Seismic Velocity, Poroelastic Response, and Numerical Modeling
Authors: Marjanović Milena , Barreyre Thibaut , Fontaine Fabrice J. , Escartín Javier
Published: September 2019

Along with the intracrustal heat source, crustal permeability is considered as the controlling factor for hydrothermal circulation within zero‐age oceanic crust. To obtain fine‐scale, 2‐D models of upper crustal permeability along the East Pacific Rise 9°50′N, known for prolific hydrothermal activity, we use recently derived high‐resolution seismic velocity and examine a number of the existing velocity‐permeability relationships. To constrain our preferred permeability model, we compare thus derived permeability models with collocated permeability estimates from poroelastic response to tidal loading at L‐vent. Furthermore, using the preferred permeability result, we model hydrothermal convection in 2‐D and find that the distributions of recharge and discharge zones are in good agreement with seafloor observations, including locations of the vent fields. Our results suggest that seismic velocities can be used as a tool for deriving spatial variation of permeability, which must be considered in modeling of hydrothermal flow.
Indirubin-3′-oxime stimulates chondrocyte maturation and longitudinal bone growth via activation of the Wnt/β-catenin pathway
Authors: Choi Sehee , Cha Pu-Hyeon , Kim Hyun-Yi , Choi Kang-Yell
Published: September 2019

Researchers have shown increased interest in determining what stimulates height. Currently, many children undergo precocious puberty, resulting in short stature due to premature closure of the growth plate. However, the current approach for height enhancement is limited to growth hormone treatment, which often results in side effects and clinical failure and is costly. Although recent studies have indicated the importance of paracrine signals in the growth plate for longitudinal bone growth, height-stimulating agents targeting the signaling pathways involved in growth plate maturation remain unavailable in the clinic. The Wnt/β-catenin pathway plays a major role in the maturation of growth plate chondrocytes. In this study, by using an ex vivo tibial culture system, we identified indirubin-3′-oxime (I3O) as a compound capable of enhancing longitudinal bone growth. I3O promoted chondrocyte proliferation and differentiation via activation of the Wnt/β-catenin pathway in vitro. Intraperitoneal injection of I3O in adolescent mice increased growth plate height along with incremental chondrocyte maturation. I3O promoted tibial growth without significant adverse effects on bone thickness and articular cartilage. Therefore, I3O could be a potential therapeutic agent for increasing height in children with growth retardation.
E6-induced selective translation of WNT4 and JIP2 promotes the progression of cervical cancer via a noncanonical WNT signaling pathway
Authors: Zhao Lin , Wang Longlong , Zhang Chenglan , Liu Ze , Piao Yongjun , Yan Jie , Xiang Rong , Yao Yuanqing , Shi Yi
Published: September 2019

mRNA translation reprogramming occurs frequently in many pathologies, including cancer and viral infection. It remains largely unknown whether viral-induced alterations in mRNA translation contribute to carcinogenesis. Most cervical cancer is caused by high-risk human papillomavirus infection, resulting in the malignant transformation of normal epithelial cells mainly via viral E6 and E7 oncoproteins. Here, we utilized polysome profiling and deep RNA sequencing to systematically evaluate E6-regulated mRNA translation in HPV18-infected cervical cancer cells. We found that silencing E6 can cause over a two-fold change in the translation efficiency of ~653 mRNAs, most likely in an eIF4E- and eIF2α-independent manner. In addition, we identified that E6 can selectively upregulate the translation of WNT4, JIP1, and JIP2, resulting in the activation of the noncanonical WNT/PCP/JNK pathway to promote cell proliferation in vitro and tumor growth in vivo. Ectopic expression of WNT4/JIP2 can effectively rescue the decreased cell proliferation caused by E6 silencing, strongly suggesting that the WNT4/JIP2 pathway mediates the role of E6 in promoting cell proliferation. Thus, our results revealed a novel oncogenic mechanism of E6 via regulating the translation of mRNAs.
A founder deletion in the TRPM1 gene associated with congenital stationary night blindness and myopia is highly prevalent in Ashkenazi Jews
Authors: Hirsch Yoel , Zeevi David A. , Lam Byron L. , Scher Sholem Y. , Bringer Rachel , Cherki Bitya , Cohen Cadina C. , Muallem Hagit , Chiang John , Pantrangi Madhulatha , Ekstein Josef , Johansson Martin M.
Published: September 2019

Congenital stationary night blindness (CSNB) is a disease affecting the night vision of individuals. Previous studies identified TRPM1 as a gene involved in reduced night vision. Homozygous deletion of TRPM1 was the cause of CSNB in several children in 6 Ashkenazi Jewish families, thereby prompting further investigation of the carrier status within the families as well as in large cohorts of unrelated Ashkenazi and Sephardi individuals. Affected children were tested with a CSNB next-generation (NextGen) sequencing panel. A deletion of TRPM1 exons 2 through 7 was detected and confirmed by PCR and sequence analysis. A TaqMan-based assay was used to assess the frequency of this deletion in 18266 individuals of Jewish descent. High-throughput amplicon sequencing was performed on 380 samples to determine the putative deletion-flanking founder haplotype. Heterozygous TRPM1 deletions were found in 2.75% (1/36) of Ashkenazi subjects and in 1.22% (1/82) individuals of mixed Ashkenazi/Sephardic origin. The homozygous deletion frequency in our data was 0.03% (1/4025) and was only found in Ashkenazi Jewish individuals. Homozygous deletion of exons 2–7 in TRPM1 is a common cause of CSNB and myopia in many Ashkenazi Jewish patients. This deletion is a founder Ashkenazi Jewish deletion.
A novel kit for early diagnosis of Alzheimer’s disease using a fluorescent nanoparticle imaging
Authors: Park Jun Sung , Kim Sang Tae , Kim Sang Yun , Jo Min Gi , Choi Myeong Jun , Kim Myeong Ok
Published: September 2019

Alzheimer’s disease (AD) is a progressive neurodegenerative disease and chronic illness with long preclinical phases and a long clinical duration. Until recently, a lack of potential therapeutic agents against AD was the primary focus of research, which resulted in less effort directed towards developing useful diagnostic approaches. In this study, we developed a WO2002/088706 kit that is composed of fluorescent nanoparticles for the early detection of AD. We provided a fluorescent nanoparticle for detecting markers and a kit for the early diagnosis of AD. The kit consists of a probe molecule comprising an oligonucleotide capable of detecting one or more AD-specific microRNAs (miRNAs) and biomarkers related to AD. Through screening, we selected miR-106b, miR-146b, miR-181a, miR-200a, miR-34a, miR-124b, miR-153, miR-155, Aβ1-42 monomer (mAβ), Aβ1–42 oligomer (oAβ), UCHL1, NLRP3, Tau, STAT3, SORL1, Clusterin, APOE3, APOE4, Nogo-A, IL-13, and Visfatin to serve as AD- and inflammation-related markers. For detection of kit-binding properties, we checked the expression levels of amyloid beta (Aβ), tau protein, and inflammatory mediators in APP/PS/ApoE knockdown (KD) mice and a control group using co-localisation analysis conducted with a confocal microscope. Using a similar approach, we checked the expression levels of miRNAs in HT22 cells. Finally, we used the plasma from AD patients to confirm that our fluorescent nanoparticles and the WO2002/088706 kit will provide a possible early diagnosis to serve as an AD detector that can be further improved for future studies on targeting AD.
Author Correction: Bcl11b controls odorant receptor class choice in mice
Authors: Enomoto Takayuki , Nishida Hidefumi , Iwata Tetsuo , Fujita Akito , Nakayama Kanako , Kashiwagi Takahiro , Hatanaka Yasue , Kondo Hiro , Kajitani Rei , Itoh Takehiko , Ohmoto Makoto , Matsumoto Ichiro , Hirota Junji
Published: September 2019

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Chemical imaging of human teeth by a time-resolved Raman spectrometer based on a CMOS single-photon avalanche diode line sensor
Authors: Kekkonen Jere , Finnilä Mikko A. J. , Heikkilä Jarkko , Anttonen Vuokko , Nissinen Ilkka
Published: September 2019

Improvement to the spectral quality of Rama images of human teeth were achieved with a time-resolved CMOS SPAD-based Raman spectrometer.
Synthetic bioresorbable poly-α-hydroxyesters as peripheral nerve guidance conduits; a review of material properties, design strategies and their efficacy to date
Authors: Duffy Patrick , McMahon Seán , Wang Xi , Keaveney Shane , O'Cearbhaill Eoin D. , Quintana Iban , Rodríguez Francisco J. , Wang Wenxin
Published: September 2019

Implantable tubular devices known as nerve guidance conduits (NGCs) have drawn considerable interest as an alternative to autografting in the repair of peripheral nerve injuries.
Yeast glucan particles enable intracellular protein delivery inDrosophilawithout compromising the immune system
Authors: Bajgar Adam , Saloň Ivan , Krejčová Gabriela , Doležal Tomáš , Jindra Marek , Štěpánek František
Published: September 2019

Glucan particles spread through the whole organism quickly, accumulate in sites of macrophage occurrence and can deliver cargo into the macrophages with a negligible effect on immune response activation.
Two-dimensional supramolecular assemblies based on β-cyclodextrin-grafted graphene oxide for mitochondrial dysfunction and photothermal therapy
Authors: Zhang Bing , Yu Qilin , Zhang Ying-Ming , Liu Yu
Published: September 2019

A 2D supramolecular nanoassemblies specifically target the mitochondria of tumor cells and severely disrupt mitochondrial function in a photocontrollable manner, leading to remarkable inhibition of tumor growth.
Oil-in-eutectic mixture HIPEs co-stabilized with surfactant and nanohydroxyapatite: ring-opening polymerization for nanocomposite scaffold synthesis
Authors: García-Landeros Sergio A. , Cervantes-Díaz José M. , Gutiérrez-Becerra Alberto , Pelayo-Vázquez José B. , Landazuri-Gomez Gabriel , Herrera-Ordonez Jorge , Soltero-Martínez J. Félix Armando , Mota-Morales Josué D. , Pérez-García María G.
Published: September 2019

Biodegradable macroporous polyHIPEs with specific cavity sizes and selective interfacial functionalization of the inner surface with NHA are produced.
Tunable mechanochromic luminescence of 2-alkyl-4-(pyren-1-yl)thiophenes: controlling the self-recovering properties and the range of chromism
Authors: Ikeya Minako , Katada Genki , Ito Suguru
Published: September 2019

High-contrast self-recovering mechanochromic luminescence (MCL) has been achieved by tuning the MCL behavior of 2-alkyl-4-(pyren-1-yl)thiophenes.
Correction: Synthesis of hydrophobic and hydrophilic TiO2 nanofluids for transformable surface wettability and photoactive coating
Authors: Hu Jie , Zhao Tian , Geng Wei , Lu Yi , Zhao Xiao-Fang , Li Yuan-Zhou , Tang Yu-Qian , Liu Jia-Wen , Wang Li-Ying , Janiak Christoph , Yang Xiao-Yu , Su Bao-Lian
Published: September 2019

Correction for ‘Synthesis of hydrophobic and hydrophilic TiO2 nanofluids for transformable surface wettability and photoactive coating’ by Jie Hu et al., Chem. Commun., 2019, 55, 9275–9278.
Controllable synthesis of multi-morphological SrWO4:Ln3+ (Ln = Eu, Tb) hierarchical structures and their luminescence properties
Authors: Huang Jingbin , Lu Wei , Yue Dan , Wang Yanyan , Wang Zhenling , Jin Lin , Zhang Lianzhong , Li Zhongjun
Published: September 2019

Multi-morphological SrWO4:Ln3+ hierarchical structures including dumbbell-like, nanosheets, rice-like, peanut-like, etc. could be controllably synthesized through readily altering reaction conditions.
Rb3SbF3(NO3)3: an excellent antimony nitrate nonlinear optical material with a strong second harmonic generation response fabricated by a rational multi-component design
Authors: Wang Lei , Yang Fei , Zhao Xiaoyu , Huang Ling , Gao Daojiang , Bi Jian , Wang Xin , Zou Guohong
Published: September 2019

Rb3SbF3(NO3)3fabricated by a rational multi-component design exhibits a strong phase-matching SHG response and a wide transmission window.
Resonant doping for high mobility transparent conductors: the case of Mo-doped In2O3
Authors: Swallow Jack E. N. , Williamson Benjamin A. D. , Sathasivam Sanjayan , Birkett Max , Featherstone Thomas J. , Murgatroyd Philip A. E. , Edwards Holly J. , Lebens-Higgins Zachary W. , Duncan David A. , Farnworth Mark , Warren Paul , Peng Nianhua , Lee Tien-Lin , Piper Louis F. J. , Regoutz Anna , Carmalt Claire J. , Parkin Ivan P. , Dhanak Vin R. , Scanlon David O. , Veal Tim D.
Published: September 2019

Superior transparent conducting properties of indium oxide realised by molybdenum donors resonant in the conduction band, avoiding detrimental effects of tin doping.
Application of isatin-derived saturated esters in the synthesis of 3,3′-spirooxindole γ-butyrolactams
Authors: Zhu Jindong , Fang Shuaishuai , Jin Shiyi , Ma Rui , Lu Tao , Du Ding
Published: September 2019

Isatin-derived saturated esters have been utilized as 3-carbon synthons in a base-promoted formal [3 + 2] annulation with N-Boc imines for the synthesis of two classes of 3,3′-spirooxindole γ-butyrolactams.
Anchoring carbon layers and oxygen vacancies endow WO3−x/C electrode with high specific capacity and rate performance for supercapacitors
Authors: Xu Juan , Li Chongyang , Chen Lulu , Li Zhongyang , Bing Pibin
Published: September 2019

A high-performance supercapacitor electrode comprising hierarchical carbon layer-anchored WO3−x/C nanowires with inner abundant redox reaction active sites and numerous oxygen vacancies is presented.
Preparation of recyclable MoO3 nanosheets for visible-light driven photocatalytic reduction of Cr(vi)
Authors: Wei Wenxian , Zhang Zhenxin , You Guoxiang , Shan Yun , Xu Zuozheng
Published: September 2019

The exploitation of stable and earth-abundant photocatalysts with high catalytic activity remains a significant challenge for removing heavy metals from wastewater.
Enhanced furfural production from biomass and its derived carbohydrates in the renewable butanone–water solvent system
Authors: Zhao Yuan , Xu Hao , Wang Kaige , Lu Kaifeng , Qu Yang , Zhu Lingjun , Wang Shurong
Published: September 2019

The renewable butanone–water solvent system provides an efficient and cost-effective strategy for furfural production from biomass and its derived carbohydrates.
A high-performance cupric oxide photocatalyst with palladium light trapping nanostructures and a hole transporting layer for photoelectrochemical hydrogen evolution
Authors: Masudy-Panah Saeid , Katal Reza , Khiavi Negar Dasineh , Shekarian Ehsan , Hu Jiangyong , Gong Xiao
Published: September 2019

The high recombination rate of photogenerated electron–hole pairs, poor photocorrosion stability, and the discrepancy between the optical absorption length and charge collection efficiency of cupric oxide (CuO) are the main limiting factors of CuO photocatalysts.
Recent progress in the synthesis, structural diversity and emerging applications of cyclodextrin-based metal–organic frameworks
Authors: He Yuanzhi , Hou Xuefeng , Liu Ying , Feng Nianping
Published: September 2019

This review takes an overview of the synthetic strategies, structural diversity and emerging bio-related applications of cyclodextrin-based metal–organic frameworks (CD-MOFs).
An unusual plank-shaped nematogen with a graphene nanoribbon core
Authors: Farias Giliandro , Simeão David S. , Moreira Thamires S. , dos Santos Paloma L. , Bentaleb Ahmed , Girotto Edivandro , Monkman Andrew P. , Eccher Juliana , Durola Fabien , Bock Harald , de Souza Bernardo , Bechtold Ivan H.
Published: September 2019

Laterally decorated ribbon-shaped graphene segments made of twelve benzene units self-assemble into a nematic anisotropic glass at room temperature with high birefringence and polarized fluorescence.
Aggregation-induced emission triggered by the radiative-transition-switch of a cyclometallated Pt(ii) complex
Authors: Sun Yuanhui , Yang Xiaolong , Liu Boao , Guo Haoran , Zhou Guijiang , Ma Wei , Wu Zhaoxin
Published: September 2019

A new mechanism, namely radiative transition switch (RTS), has been proposed for aggregation-induced emission, which is of importance for developing highly efficient AIE-active emitters.
Impact of SiO2 surface composition on trimethylsilane passivation for area-selective deposition
Authors: Soethoudt Job , Crahaij Steven , Conard Thierry , Delabie Annelies
Published: September 2019

Increasing the initial –OH group density on SiO2 surfaces improves dimethylamino-trimethylsilane passivation and increases selectivity for area-selective deposition.
Highly ordered columnar superlattice nanostructures with improved charge carrier mobility by thermotropic self-assembly of triphenylene-based discotics
Authors: Bi Jingze , Wu Hao , Zhang Zhenhu , Zhang Ao , Yang Huanzhi , Feng Yuwen , Fang Yi , Zhang Lina , Wang Zhengran , Qu Wentao , Liu Feng , Zhang Chunxiu
Published: September 2019

A series of triphenylene esters with two ester groups at different substituent positions was synthesized and investigated. 3,6-substituted molecule formed a helical hexagonal columnar superstructure, leading to improved charge carrier mobility.
Discovery of intergalactic bridges connecting two faintz∼ 3 quasars
Authors: Arrigoni Battaia F. , Obreja A. , Prochaska J. X. , Hennawi J. F. , Rahmani H. , Bañados E. , Farina E. P. , Cai Z. , Man A.
Published: September 2019

We used the Multi-Unit Spectroscopic Explore (MUSE) on the Very Large Telescope (VLT) to conduct a survey ofz ∼ 3 physical quasar pairs at close separation (<30″) with a fast observation strategy (45 min on source). Our aim is twofold: (i) to explore the Lyαglow around the faint-end of the quasar population; and (ii) to take advantage of the combined illumination of a quasar pair to unveil large-scale intergalactic structures (if any) extending between the two quasars. In this work we report the results for the quasar pair SDSS J113502.03−022110.9 – SDSS J113502.50−022120.1 (z  =  3.020, 3.008;i  =  21.84, 22.15), separated by 11.6″ (or 89 projected kpc). MUSE reveals filamentary Lyαstructures extending between the two quasars with an average surface brightness of SBLyα  =  1.8 × 10−18erg s−1cm−2arcsec−2. Photoionization models of the constraints in the Lyα, He IIλ1640, and C IVλ1548 line emissions show that the emitting structures are intergalactic bridges with an extent between ∼89 kpc, the quasars’ projected distance, and up to ∼600 kpc. Our models rule out the possibility that the structure extends for ∼2.9 Mpc, that is, the separation inferred from the uncertain systemic redshift difference of the quasars if the difference was only due to the Hubble flow. At the current spatial resolution and surface brightness limit, the average projected width of an individual bridge is ∼35 kpc. We also detect one strong absorption in H I, N V, and C IValong the background sight-line at higherz, which we interpret to be due to at least two components of cool (T ∼ 104K), metal enriched (Z >  0.3 Z⊙), and relatively ionized circumgalactic or intergalactic gas surrounding the quasar pair. Two additional H Iabsorbers are detected along both quasar sight-lines at ∼−900 and −2800 km s−1from the system; the latter has associated C IVabsorption only along the foreground quasar sight-line. The absence of galaxies in the MUSE field of view at the redshifts of these two absorbers suggests that they trace large-scale structures or expanding shells in front of the quasar pair. Combining longer exposures and higher spectral resolution when targeting similar quasar pairs has the potential to firmly constrain the physical properties of gas in large-scale intergalactic structures.
The screaming balloon: predicting the sound produced by a hex nut inside a balloon
Authors: Ferreira Henrique , Pessoa Matheus , Gitti Ricardo R. , Ferreira-Martins André J. , de Souza Gustavo , Dominiquini Andrius , Coimbra Lucas , Rios Lucas
Published: September 2019

In this work we studied the sound produced by the movement of a hex nut inside an air balloon. We demonstrated, by experiments with hex nuts and nuts without edges, the importance of the nut edges for the production of the screaming sound. Our experimental results show that the most intense frequency of the sound spectrum is directly proportional to the hex nut’s speed of translation, while inversely proportional to its lateral length, thus allowing one to predict the most intense frequency generated by this system.
Characteristics of the odontological management of patients with progressive ossifying fibrodyplasia
Authors: Ibourk Aicha , Bouzoubaa Sidi Mohammed , Ben Yahya Ihsane
Published: September 2019

Introduction: Progressive ossifying fibrodysplasia (POF) is a rare autosomal dominant disease characterized by the congenital malformation of the big toes and progressive postnatal heterotopic ossification of soft tissues with characteristic anatomical profiles. The maxillofacial region may also be affected. Observation: A 24-year-old man was referred by a traumatologist for the restoration of the oral cavity. He showed characteristic signs of POF. Oral clinical examination showed limitation of the oral opening, multiple dental caries, dental necrosis, and an asymptomatic impacted 48. Management included motivation for oral hygiene, scaling and dental extractions, followed by a prescription of steroidal anti-inflammatory drugs at a single dose of 2 mg/kg/day for 4 days. Discussion: The management of patients with POF in oral surgery has particularities. Dental care must be performed in brief sessions. The patient must be in a semi-sitting position, with the neck held upright, to avoid hyper extension of the neck and to improve comfort and safety. A prescription for corticosteroids is necessary after dental care to prevent possible heterotopic ossification. Through this article, we highlight the characteristics of POF, therapeutic attitude, and precautions to take to avoid possible complications.