bluuebunny/crossref_metadata_2025 huggingface dataset:
DIAGNOSTIC ERRORS DURING INTRAMEDULLAR PROCESSES
Authors: Tarianyk Kateryna , Lytvynenko Natalia , Purdenko Tetiana , Hladka Viktoriia
Published: October 2020

Introduction: The article describes a clinical case of a malignant tumor of the brain and spinal cord with metastasis, which remained undetected for many years and was treated as syringomyelia. Long-term exhausting examinations of the brain and spinal cord, dynamic follow-up of medical specialists, and repeated surgical interventions on the spine helped to differentiate this process and make the correct diagnosis. The aim: The objectives of the present paper are to analyze the existing classifications of syringomyelia; to examine its etiology, pathogenesis, diagnostic approaches and treatment tactics; to present a clinical case of a malignant tumor of the brain and spinal cord with metastasis, which was misdiagnosed as syringomyelia. Materials and methods: The authors analyzed the existing classifications of syringomyelia and studied its etiology, pathogenesis, diagnostic approaches and treatment tactics using the method of content analysis, analyticalб comparative and contrastive methods. Clinical case: The described clinical case is a variant of the course of syringomyelia, associated with the spinal cord tumor, namely, in particular, anaplastic ependymoma. For a long time, the process remained undetected, despite the long-term examination and drainage of the syringomyelic cavity. Analyzing this case, it is highly important to pay attention to careful history collection, examination of the patient, analysis of the occurrence of certain disorders in order to conduct the neuroimaging examinations in time. Conclusions: Favorable outcome of the disease is directly related to the diagnosis at early stages, especially in young people, the clinical variant of the process, progression of the course, the degree of involvement of various parts of the nervous system and extraneural formations, the severity of the lesion. The treatment tactics and the ability to restore the functions will depend on all these factors.
ANTIMICROBIAL RESISTANCE OF STAPHYLOCOCCUS AUREUS
CAUSING OF SURGICAL SITE INFECTIONS IN EAR, NOSE AND
THROAT SURGERY
Authors: Salmanov Aidyn G. , Shkorbotun Volodymyr O. , Shkorbotun Yaroslav V.
Published: October 2020

Introduction: Staphylococcus aureus is one of the major pathogens that causes of surgical site infection (SSI). Scant information is available on the occurrence and antimicrobial
susceptibility of S. aureus in patients with SSI in Ear, Nose and Throat (ENT) surgery.
The aim: To assess the activity of antimicrobials against S.aureus, isolated from patients with SSI by the ENT departments of Kyiv hospitals.
Materials and methods: A total of 516 S. aureus isolates from of patients with SSI in ENT surgery. Antimicrobial susceptibility of S. aureus were determined, using automated
microbiology analyzer. Some antimicrobial susceptibility test used Kirby – Bauer antibiotic testing. Interpretative criteria were those suggested by the Clinical and Laboratory
Standards Institute (CLSI).
Results: The most active antibiotics found in the study were linezolid and tigecycline, showing growth inhibition of 100% strains tested. Susceptibility to the other antimicrobials
was also on a high level: 98,4% of strains were found susceptible to nitrofurantoin, 98.1% – to trimethoprim/sulphamethoxazole, 97.6% – to fusidic acid, 97.1% – to mupirocin,
95.9% – to teicoplanin, 94.7% – to vancomycin and fosfomicin, 90.6% – to moxifloxacin, 89.1% – to tobramycin, 87.3% – to gentamycin. Susceptibility to rifampicin (85.5%),
cefoxitin (84.6%), levofloxacin (84.3%), erythromycin (82.6%), tetracycline (76.3%), and clindamycin (75.4%) was observed to be some lower. Resistance to oxacyllin S.aureus
(MRSA) came up to 21.1%.
Conclusions: S. aureus in ENT departments to be a serious therapeutic and epidemiologic problem. The constant monitoring of antimicrobials resistance in every hospital is
required. Antibiotics application tactics should be determined in accordance with the local data of resistance to them.
PSYCHOLOGICAL FEATURES OF MOTIVATIONAL SPHERE
OF DRUG ADDICTS
Authors: Mykhaylyshyn Ulyana В.
Published: October 2020

Introduction: The article considers the psychological features of motivational sphere of drug addicts. The article presents the results of the empirical study of the specifics of
motivational sphere of drug addicts with the subsequent statistical analysis.
The aim of this study is to identify psychological characteristics of motivational sphere of drug addicts.
Materials and methods: The research has been conducted at Transcarpathian Oblast Narcological Dispensary (Uzhhorod, Ukraine). The experiment involved 30 drug addicts
of different age and sexes. In order to diagnose the motivational sphere of drug addicts, the following methods have been used: Diagnostics of motivation to avoid failure by
T. Ehlers; Measuring the motivation to success by T. Ehlers; Diagnostics of risk attitude by G. Schubert.
Results: It has been found that the determining factors of motivation for drug abuse are: social and psychological conditions of life, factors of group influence, direct psychophysiological
influence of drugs, daring illusory satisfaction. It has been determined that young people with unstable spiritual needs and lack of stable positive interests are
the category who is the most inclined to drug abuse.
Conclusions: The data of statistical, quantitative and qualitative analysis has been obtained allowing concluding that the development of destructive motivation affects the
inclination to using the narcotic substances.
THE PECULIARITIES OF THE HEART RATE VARIABILITY
AND ELECTROENCEPHALOGRAM CHANGES IN PATIENTS
WITH EPILEPSY AND CARDIOVASCULAR PATHOLOGY
Authors: Litovchenko Tetiana , Grymailo Valeriia , Tondiy Oksana , Florikian Vartanush , Zavalna Olena , Voitiuk Anna
Published: October 2020

Introduction: Epidemiological studies have shown that the risk of myocardial infarction and stroke is significantly higher in patients with epilepsy compared with people not
suffering from epilepsy.
The aim of the study was to study the parameters of HRV and EEG in patients with epilepsy to identify risk factors for cardiovascular pathology.
Materials and methods: We observed 50 patients with epilepsy without cardiovascular pathology (group 1) and 56 patients with epilepsy and cardiovascular pathology
(group 2). All patients underwent clinical neurological examination, EEG, HRV and ECG assessment.
Results: There was a significant decrease in the HRV power in both groups of patients compared with general population data (p <0.02). Also in patients of the 2nd group, TP
and the power of HRV in the LF, HF ranges were significantly decreased (p <0.001). Unstrained autonomic balance was detected in 40% in the 1st group and in 6% of patients
in the 2nd group (p <0.001). Each patient had as higher LF/HF ratio as less time to next seizure left (rs = 0.72; p <0.05). There was no correlation of the heart rate (ECG) and the
time to the next seizure (rs = 0.12; p <0.05). A correlation of the LF / HF ratio with β rhythm (EEG) was revealed for patients in both groups (for group 1: rs = 0.48; for group 2:
rs = 0.52; p <0.02). When evaluating HRV in both groups, depending on the taken AEDs, it was found that the average values of TP, VLF, LF, HF, SDNN were significantly lower
in patients receiving carbamazepine when compared with patients receiving other AEDs (p<0.001).
Conclusions: The factors of increased cardiovascular risk were: tense autonomic balance with a tendency to sympathicotonia, signs of a decrease in parasympathetic activity, a
decrease in the TP, an increase in the representation of the EEG β-rhythm. The magnitude of the change in the frequency of the α rhythm in response to hyperventilation as well
as the magnitude of the change in TP in orthostasis can serve as indicators of the adaptation reserve in patients with epilepsy. The development of an acute vascular event may
increase the frequency of seizures and the presence of paroxysmal EEG phenomena. HRV is more informative to determine the oncoming of the seizure, than the routine ECG.
Levetiracetam and lamotrigine have a more favorable effect on the autonomic balance of the heart than carbamazepine and valproic acid.
INFLUENCE OF THE TRANSFERRED SYPHILITIC INFECTION ON THE COURSE OF PREGNANCY, CHILDBIRTH AND THE STATE OF NEWBORNS
Authors: Husiev Viacheslav M. , Khapchenkova Daria S.
Published: October 2020

Introduction: The article presents information about the peculiarities of the course of pregnancy and childbirth in women with a syphilitic infection in the anamnesis. The
peculiarities of the state of newborn babies born from mothers who have suffered syphilis are described. To date, the incidence of syphilis in Ukraine has a clear tendency to
decline, but still remains quite high. The maximum incidence of syphilis is observed in women aged 15-20 years. The combination of pregnancy and syphilitic infection in an
anamnesis is an unfavorable factor in regard to high risk of perinatal complications, the frequency of which does not tend to decrease.
The aim - study the features of the course of pregnancy and childbirth in women with a syphilitic infection in the anamnesis, the evaluation of the state of newborns.
Materials and methods: A prospective examination of 57 healthy women and their newborns (control group) and 60 pregnant women with a history of syphilitic infection
(the main group) had been conducted. All pregnant women had undergone ultrasound examination, including feto- and placentometry, an estimate of the amount of amniotic
fluid. The effect of the transferred syphilis on the state of the newborn had been assessed in accordance with the results of the clinical examination of an anthropometric data,
including an Apgar score.
Results: It is stated that the incidence of latent (41,66%) and forms with a prolonged course (20,00%) of syphilitic infection. The threat of premature childbirth was almost
3,5 times higher than in women with syphilis, cases of an anemia in pregnant women – 2 times, hypertensive disorders of pregnant women were 2,4 times more common in
women of the main group, fetal development retardation syndrome 6,4 times, while a greater percentage of this disorder was recorded among women in the main group who
were ill with latent forms and suffered secondary recurrent syphilis (35%). In 20% of the cases, pregnancy in women with syphilis has been completed by the cesarean section,
an abnormality of the contractile capacity of the uterus was significantly higher – 23,33%. The adaptive capacity of the newborns in the main group has been significantly
lower, compared to the control group.
Conclusions: Syphilitic infection in the anamnesis complicates the course of pregnancy with numerous pathological conditions. Syphilitic infection, borne before pregnancy,
affects not only the course of pregnancy, but also the course of childbirth and the postpartum period. The pathological conditions in infants are due to a decrease in resistance to
birth stress, early depletion of adaptive resources of newborns under the influence of a syphilitic infection of the mother. In children who have experienced chronic intrauterine
hypoxia, the risk of hemorrhagic syndrome is significantly higher due to increased permeability of the vascular wall. Such children have a tendency to develop neurological
disorders and respiratory system lesions.
BIOCHEMICAL MARKERS OF CONNECTIVE TISSUE METABOLISM IN
RATS’ BLOOD SERUM WITH EXPERIMENTAL KNEE OSTEOARTHRITIS
AND THEIR DYNAMICS DURING CONSERVATIVE TREATMENT
Authors: Makolinets Kyrylo V. , Makolinets Vasyl I. , Morozenko Dmytro V. , Gliebova Kateryna V. , Danylchenko Svitlana I.
Published: October 2020

Introduction: There are many methods for diagnosis and treatment of knee joints osteoarthritis in modern orthopedics. The infrared radiation is one of the most popular and
effective methods though it needs experimental substantiation on rats.
The aim: Experimental definition of the effectiveness of the proposed method of conservative treatment of knee joints osteoarthritis using sodium diclofenac, glucosamine
hydrochloride and infrared laser radiation, on the basis of biochemical markers of connective tissue metabolism in rats.
Materials and methods: Experimental studies were performed on 40 white male rats. A part of rats received infrared laser radiation in addition to diclofenac sodium and glucosamine hydrochloride.
Results: Using a complex of infrared laser radiation and glucosamine hydrochloride and diclofenac sodium in conservative treatment of rats with experimentally induced knee
joints osteoarthritis rats after 24 days of treatment. Treatment with the above-mentioned scheme resulted in a significant reduction in the content of glycoproteins (28.5%),
chondroitin sulfates (26.1%), alkaline phosphatase activity (32.3%), and I and II fractions of glycosaminoglycans, namely chondroitin-6- (28.7%) and chondroitin-4-sulfate
(40.3%). Moreover, these indicators of the studied markers approached the level of intact animals.
Conclusions: Changes in biochemical markers of connective tissue in rats during experimental knee joints osteoarthritis indicated a higher efficiency of the treatment regimen
with the use of low-intensity infrared laser radiation compared with exclusively drug therapy.
FORENSIC MORPHOLOGICAL SIGNS CHARACTERIZING STABILITY
OF THE FEMUR, TIBIA AND FIBULA DURING EFFECT OF EXTERNAL
DESTRUCTIVE LOAD
Authors: Savka Ivan G.
Published: October 2020

Introduction: Fractures of the lower limb bones very often become the subject of forensic expertise when experts have to determine the mechanisms of fracture formation,
make retrospective restoration of conditions of their occurrence, solve the issues concerning the possibility of their formation under certain conditions.
The aim of study is directed to investigation of morphological signs facilitating solidity of the osseous tissue of the lower limb long tubular bones, and therefore, promoting
biochemical processes of their destruction in case of external traumatic impact.
Materials and methods: Expert investigations included 128 injuries of the long tubular bones of the lower limb: femoral bone – 40 cases, tibia – 46, fibula – 42. Fractures of
every bone were assessed by the three thirds: proximal, middle and distal. All the 29 macroscopic and 8 microscopic morphological signs of the osseous tissue were examined.
Control studies were carried out on 576 specimens of the femoral bone, tibia and fibula (192 specimens of each), removed from dead males and females aged from 24 to 70.
Results: The most valuable morphological signs forming “modulus of stability” are: length of plastic deformity zones from the site of stretching and compression, deviation angle of
sphenoid cracks together with the character of traumatic injury impact. An important value in this respect belongs to the square of the medullar canal, length of the biggest sphenoid
crack, number of longitudinal cracks and shape of the medullar canal from the site of compression, total mineral content and the height of the biggest crest in the rupture zone.
Conclusions: “Modulus of stability” of the osseous tissue of the long tubular bones of the lower limb most accurately reflects interaction of traumatic mechanical impact with
the bone structures during their injuries that should be considered in forensic practice in the process of making expertise.
MORPHOFUNCTIONAL STATUS OF CARDIO-VASCULAR SYSTEM
OF RATS WITH CONGENITAL HYPOTHYREOSIS
Authors: Chuhray Svitlana M. , Lavrynenko Viktoria E. , Kaminsky Rostyslav F. , Dzevulska Iryna V. , Malikov Olexandr V. , Kovalchuk Olexandr I. , Sokurenko Liudmyla M.
Published: October 2020

Introduction: There is an increasing number of cases of congenital hypothyroidism. One of the most common complications of hypothyroidism is damage to the cardiovascular
system, which in 30-50% of patients leads to the development of arterial hypertension.
The aim: studying the features of the ultrastructure of myocardial capillaries in mature rats with hypothyroidism.
Materials and methods: Experiments were conducted on 40Wistar line rats with congenital hypothyroidism: juvenile young (45-day) and sexually mature (100-day) rats, as well
as intact animals of the corresponding age. While extracted from the experiment rats of all experimental groups had their arterial pressure measured using a plethysmograph while
the development of hypothyroidism was controlled by the immune-enzymatic method. Electron microscopic examination of the left ventricular myocardium and morphometric
study of volumetric and quantitative densities, cross-section area, and form factor of micropinocytotic vesicles were conducted.
Results: In the sexually mature rats with congenital hypothyroidism the quantitative density of the capillaries in the myocardium decreases. Activation of transcytosis is
accompanied by significant violations of vesiculation. Some of the endothelial cells of experimental animals contain a moderate amount of transport vesicles, while others
are overfilled with these structures and desquamate into the lumen. In older rats with congenital hypothyroidism there is a further dilution of capillaries, the development of
hypoxic state in them, mucinous edema of interstitial space, decrease of biosynthetic and transport processes activity.
Conclusions: In young (45-day) rats with congenital hypothyroidism the direction and expressiveness of compensatory processes is to enhance the transcytosis processes. Dystrophicdestructive
changes are manifested by apoptosis in some endothelial cells, decrease in the number of biosynthetic organelles, lysis and edema of their cytoplasm. In sexually mature
(100-day) rats with congenital hypothyroidism destructively-dystrophic processes in the blood capillaries of the myocardium are approximately balanced with compensatory-adaptive.
OGILVIE SYNDROME – CASE REPORT
Authors: Gajda Dawid , Dyaczyński Michał
Published: October 2020

Ogilvie syndrome is a clinical condition in which there is a colorectal distention in the absence of mechanical obstacles. Early diagnosis and appropriate therapy significantly
reduce mortality. The incidence of this is not known. This paper presents the course of diagnosis and treatment, both conservative and operational, of an 82 year old patient
with pulmonary embolism, burdened with coronary artery disease, hypertension, heart failure and chronic kidney failure, in which the hospital diagnosed Ogilvie syndrome.
THE INFLUENCE OF VARIOUS METHODS OF ANESTHESIA ON TIME OF POSTOPERATIVE RECOVERY OF PATIENTS’ CONCIOUSNESS AFTER CURETTAGE OF UTERINE CAVITY
Authors: Georgiyants Maryne A. , Kolesnik Ganna V. , Vysotska Olena V. , Yurchenko Olha M.
Published: October 2020

Introduction: Scientific information sources point to the significant effectiveness of curettage of uterine cavity (CUC) as a diagnostic and treatment mode of gynecologic oncology. Today the anesthesia service is able to satisfy virtually all the requirements of a surgeon and a female patient, however, some institutional factors, as for example postoperative recovery of consciousness, and factors influencing it, remain unaddressed. The aim: to explore the possibilities of influence of different combinations and dosages of medical preparations used to provide monitored anesthesia care of CUC, to change the time of postoperative recovery of patient’s consciousness. Materials and methods: an interview of 96 patients by VAS, studies of cortisol, insulin and glucose levels in blood serum, measurements of time from the end of surgery to the awakening and complete recovery of consciousness and statistical processing of the results have been conducted. Results: A combination of 50 mg of dexketoprofen and half-dose drugs for narcosis can hasten the postoperative wake-up time by 38%, while maintaining dosages can prolong by 37% on the contrary. There is a dose-dependent effect of drugs for narcosis on the time of full post-operative recovery of consciousness. The reduction of their dosages by half can reduce this time by almost 40%. Conclusions: the dosage modification of anesthetic drugs and their combinations may have a significant effect on the time of postoperative awaking and complete recovery of consciousness in female patients after CUC. As a result, it has a positive physiological, psychological and social effect.
PROLACTIN IN HYPERTENSIVE MEN WITH ANDROGEN
DEFICIENCY: AN ÉMINENCE GRISE?
Authors: Vizir Vadym A. , Nasonenko Olesia V. , Demidenko Olexandr V. , Sadomov Anton S.
Published: October 2020

Introduction: Considering significant gap of convincing knowledge in the field of cardiovascular effects of prolactin and its role as a stress hormone in men precise investigations
of these peculiarities has become necessary.
The aim of this study was to find out the relationship of prolactin concentration with parameters of arterial stiffness in hypertensive men with low testosterone.
Materials and methods: In total 83 men were examined including 27 apparently healthy individuals as the control group. Physical examination, ABPM, non-invasive evaluation
of arterial stiffness and central hemodynamics parameters, answering AMS questionnaire, evaluation of total testosterone and prolactin levels using ELISA were performed.
Results: Initially 56 hypertensive patients were divided into 2 groups with regard to their total testosterone level: group 1 included 31 hypogonadal men, group 2 - 25 male
patients who had their testosterone concentrations within the normal range. Prolactin levels appeared to be significantly higher in hypertensive men with lower testosterone,
they had more unfavorable parameters of arterial stiffness and the difference between 1 and 2 group in terms of central aoSBP and aoPWV became statistically significant.
Prolactin concentration was not related with RWTT and index Aix% 75, a significant correlation was observed between prolactin and aoPWV. A strong correlation was found
between prolactin concentration and psychological symptoms in AMS.
Conclusion: Our study suggests the positive association of prolactin concentration with psychological domain of andropause symptoms and worse parameters of arterial
stiffness among hypertensive men with androgen deficiency.
ULTRAMICROSCOPIC CHANGES OF RATS PARATHYROID
GLANDS AND THYMUS AFTER SINGLE ADMINISTRATION
OF CYCLOPHOSPHAMIDE AT THE DIFFERENT PERIODS
OF OBSERVATION
Authors: Erokhina Victoria , Avilova Olga
Published: October 2020

Introduction: Cyclophosphamide has wide spectrum usage as first-line drug in cancer chemotherapy that is why a detailed study of its effect on individual cell populations is
of great interest for science and practice. The interaction of the nervous, immune and endocrine systems plays essential role in the homeostasis maintaining.
The aim: This study aimed to investigate the ultramicroscopic changes that occur in the parathyroid glands and thymus of male rats after cyclophosphamide administration.
Materials and methods: Twenty-four WAG matured male rats were divided randomly into two groups. The first group served as control and was provided 0.9% soluble sodium
chloride. The second group received cyclophosphamide in a dosage 200 mg/kg of body weight of animal by intramuscular single injection. All animals were sacrificed on the 7th
and 30th day after injection. Parathyroid gland and thymus specimens were dissected out and processed for electron microscopy.
Results: The results showed that cyclophosphamide exposure caused marked ultramicroscopic changes in rats parathyroid glands and thymus. On the 7th day after immunosuppression,
the nuclei of parathyrocytes have deep wavy invaginations, amount of the organelles that participate in the protein synthesis is reduced to a minimum in the cytoplasm of the
chief cells. Characteristic feature is the appearance of numerous plasma cells and active macrophages in thymus. There is a tendency to normalization of the parathyroid structure
on the 30th day after administration of cyclophosphamide and reduction of mitotic activity of lymphocytes in thymus, which points to the development of involution process.
Conclusions: This data can be successfully extrapolated from experimental animals to humans.
ASSESSMENT OF IRISIN CONCENTRATION IN WOMEN WITH STRESS URINARY INCONTINENCE AFTER USING EXRACORPOREAL MAGNETIC INNERVATION (EXMI) − PILOT STUDY
Authors: Weber-Rajek Magdalena , Radzimińska Agnieszka , Pilarska Beata , Kozakiewicz Mariusz , Goch Aleksander
Published: October 2020

Introduction: In Poland, urinary incontinence (UI) is the ninth in frequency of reported health problem, which occurs in 15.4% of women over 60 years of age (data of the Central Statistical Office of 2016). The search for optimal treatment methods for this disease and objective methods for assessing the effectiveness of therapy is a challenge for an interdisciplinary team of specialists. The aim: To examine the effect of Extracorporeal Magnetic Innervation (ExMI) on the Irisin concentration in women with stress urinary incontinence. Materials and methods: A total of 52 women were included in the analysis: 28 participants were allocated to the experimental group (EG) and 24 to the control group (CG). EG patients completed ExMI therapy, whereas no therapeutic intervention was applied to the CG. Irisin concentration, severity of urinary incontinence (RUIS) were measured in all women at the initial and final assessments. Results: By comparing the initial and final assessment results we have been able to demonstrate a statistically significant differences in the measured variables in the EG. No statistically significant differences in the measured variables were reported for the CG at the initial and final assessments. No correlation was observed between the Irisin concentration results and severity of urinary incontinence in the EG at the final assessment. Conclusions: There is a need for further studies of biochemical parameters in the assessment of pelvic floor muscle dysfunction.
THE RESEARCH OF ANTIMICROBIAL EFFICACY OF ANTISEPTICS
DECAMETHOXIN, MIRAMISTIN AND THEIR EFFECT ON NUCLEAR
DNA FRAGMENTATION AND EPITHELIAL CELL CYCLE
Authors: Nazarchuk Oleksandr A. , Chereshniuk Ihor L. , Nazarchuk Halyna H.
Published: October 2020

Introduction: Nowadays, the study of biological safety of modern cationic surface-active antiseptics with a wide antimicrobial spectrum has acquired particular importance.
The aim was to study antimicrobial effectiveness of antiseptics decamethoxin, miramistin and their influence on nuclear DNA fragmentation and cellular cycle.
Materials and methods: A comparative microbiological study of antimicrobial efficacy and a cytometric study of the effect of decamethoxin 0,02% and miramistin 0,01%
on the cellular cycle were carried out.
Antimicrobial activity of decamethoxin and miramistin was estimated by their minimal inhibitory and minimal microbicidal concentrations against opportunistic microorganisms
using serial double dilution technique. Decamethoxin and miramistin cytotoxicity on anterior corneal epithelial cells, after their two-week daily instillation into the eyes of a
Vistar line male rats was studied using flow cytometry. The parameters of epithelial cellular cycle, nuclear DNA fragmentation and apoptosis under the influence of antiseptics
were registered.
Results: High antimicrobial effect of decamethoxin and miramistin against Gram-positive, Gram-negative bacteria with the significant advantages of decamethoxin were
found (р<0,001).
Decamethoxin caused minimal influence on anterior corneal epithelial cells, the insignificant decrease of their proliferation index, low increase of apoptosis (0.68%), no
difference of mitotic activity (p>0.05). But the use of miramistin resulted in the significant increase of nuclear DNA fragmentation, decrease of proliferative activity (р<0.05).
Conclusions: Higher antimicrobial effect against a wide range of opportunistic pathogens is proved in decamethoxin 0,02% comparably to miramistin 0,01% (р<0,001). In
prolonged antiseptic use of the first one there were found no cytotoxic and no pro-apoptotic effects on the epithelium (р<0,05).
THE STATE OF OXIDATIVE HOMEOSTASIS IN CHILDREN
WITH INFLUENZA STOMATITIS
Authors: Gevkaliuk Nataliia O. , Sydliaruk Nataliya I. , Posolenyk Larysa Ya. , Vydoinyk Oksana Ya. , Kuchyrka Lesia I.
Published: October 2020

Introduction: The clinical course of acute respiratory viral infections was not sufficiently studied, specially the state of oxidative homeostasis in children with influenza stomatitis.
This fact became the base for our study.
The aim: to characterize the state of oxidative-prooxidant system as one of the factors of non-specific resistance of children` organism with influenza stomatitis.
Materials and methods: A survey was conducted on 384 children with acute respiratory viral infections aged from 6 months to 12 years, among them 318 had lesions of oral
cavity. The mild form was diagnosed in 52 children, moderately severe - in 185, severe - in 81 children. The control group consisted of children without lesions of oral cavity
(66 people). To analyze lipid peroxidation we used a spectrophotometric determination of diene conjugates. The ceruloplasmin activity and the transferrin saturation in blood
plasma by iron were determined by G. Babenko’s method.
Results: We found the intensification of lipid peroxidation: a significant increase of diene conjugates in serum up to 13.78 %, the level of which depended on the severity
of disease. We also found the activity increase of ceruloplasmin in 1,8 times in patients with severe course of disease. The saturation of blood plasma transferrin by iron was
significantly reduced - for 15.27 % in patients with severe course of influenza stomatitis.
Conclusions: Changes in antioxidant system happend due to the activation of lipid peroxidation, and because of the inability to neutralize toxic metabolites in the children`
body the intoxication syndrome developed.
RIGHT TO CHILD HEALTH IN CONTEXT OF NATURAL
ENVIRONMENTAL SECURITY
Authors: Pashkov Vitalii M. , Trotska Maryna V. , Soloviov Oleksii S.
Published: October 2020

Introduction: From different points of view, health in general and child health, in particular, constitute the highest value which preserves a significant amount of resource
potential. Child health is understood as his/her state consisting of a certain system of elements (physical, psychological, etc.) each of which, on the one hand, is characterized by
its specificity, and on the other hand, is in a complementary relationship with each other. A process of child health formation is influenced by a large number of various elements
(social, economic, etc.) and the natural environment is one of them. Its compliance with certain rules and standards that form its qualitative status affects life and health both
directly and indirectly, therefore, determination of interdependence between the natural environmental conditions and child health is important for understanding a causal
link between the specified categories.
The aim: To study provisions of international acts and other sources in order to clarify the concept of child health and a role of the natural environment of a proper quality in
the process of its formation.
Materials and methods: the paper examines provisions of international acts, some scientists’ conclusions and other sources. Different authors’ scientific viewpoints are studied
with scientific methods in the context of medical and legal components. Within the framework of the system approach, as well as analysis and synthesis, the concepts of safe
natural environment, health in general and child health, in particular, as well as importance of a safe natural environment for child health are researched.
Review: The concept of health is complex and depends on various factors including proper natural environmental conditions. Presence of dangerous environmental factors
affects occurrence of various children diseases. In the context of the natural environmental security, it is possible to indicate both general and individual natural resources. Their
deterioration may affect its condition at large.
Conclusions: Ensuring child health, his/her proper physical, psychological and other development is impossible without guaranteeing natural environmental security. Consumption
of high-quality natural resources, observance of norms and standards for the environmental security allows the human body to develop fully accumulating relevant resources
and attracting them at the right time. Ensuring the natural environment of a proper quality guarantees a greater range of opportunities for a child in the process of forming,
coming into being and maintaining his/her physical and psychological well-being, which is a prerequisite for exercising his/her other rights and proper fulfillment of his/her
duties in the process of his/her transformation and transition to adulthood.
SLEEP DISORDERS IN PARKINSON’S DISEASE
Authors: Doręgowska Magdalena , Rudzińska-Bar Monika
Published: October 2020

Sleep disorder are common non-motor symptoms in Parkinson`s disease (PD). They can be found in different sleep stages or appear during the daytime. They correlate with faster progression of motor problems and lower quality of a patient’s life. Sleep physiology, different sleep dysfunction such as: RBD-REM sleep behavior disorder, EDS – excessive daytime sleepiness, insomnia, OSAS-obstructive sleep apnea syndrome, and their clinical manifestation have been presented in this review. Diagnostic and therapy possibilities have been summarized as well. Particular attention has also been paid to the coexistence of various non-motor symptoms such as pain, depression or nocturia, and their correlations with sleeping problems.
DEVELOPMENT OF THE INNER NASAL CAVITY IN ANIMALS
IN PHYLO- AND ONTOGENESIS: FUNCTIONAL ANATOMIC
SIGNIFICANCE IN THE DEVELOPMENT PERIOD
Authors: Kuzniak Nataliya B. , Dmytrenko Roman R. , Fedoniuk Larysa Ya. , Boitsaniuk Svitlana I. , Kuzniak Liudmyla V. , Yavorskyi Andrii V. , Tkachyk Stepan V.
Published: October 2020

Іntroduction: Main functions of the inner nose in humans are respiration and olfaction. Therefore, human needs a large surface of inhalable and exhalable air contact, warming
and moistening. Importance of these organs in animals in phylogenesis before and after the secondary palate development can explain their anatomic and functional designation.
The aim is to find out the functional significance of some anatomic formations of the inner nose and their development peculiarities in phylo-and ontogenesis.
Materials and methods: We used a comparative anatomy method where we compared well-known facts of different animals’ development before and after secondary palate
formation in phylo- and ontogenesis.
Review: Olfactory organ in lower vertebrates develops as canal with two openings through which as a result of water penetration the olfactory ability increases. Sinuses
formation in animals happens after secondary palate formation. Secondary palate in embryo develops by second month of development, and sinuses’ development begins on
the 3-4 month. As a result, upper jaws and facial skull became stronger. Importance of mucous and lacrimal glands of the nose cavity and mucous glands of mouth received
new functions of animal and vegetable food digestion.
Conclusions: development of the secondary palate in warm-blooded vertebrates changed (limited) functional applicability of the lacrimal gland and nasolacrimal canal,
mucous glands of nose and vegetative innervation. Groups of lacrimal, mucous glands of nose and mouth are unified system of primary, neurosecretory reaction to environment.
MODERN APPROACH TO THE PROBLEM OF PERTUSSIS
Authors: Ilchenko Valentyna I. , Sіzova Liudmyla М. , Tanianskaia Svitlana М. , Nesina Inna N. , Pikul Kateryna V.
Published: October 2020

Introduction: Recently, there has been a tendency to increase the incidence of pertussis in many countries of the world and this disease in these countries is among 10 most serious causes of death in young children. The aim of the work − is to analyze specialized scientific literature for generalization of data and present a modern look at questions of etiology, epidemiology, pathogenesis, clinical manifestations, diagnosis, treatment and immunoprophylaxis of pertussis. Materials and methods: Available scientific sources over the past years, devoted to the problem of pertussis are studied by the methods of overview, system and content analysis. Review and conclusions: The main questions of pertussis are outlined. Timely diagnosis, treatment and immunoprophylaxis allow adjusting the actions of doctors to solve the issues of the decrease of the incidence of pertussis. This is greatly helped by modern guidelines for the management of patients with this pathology.
LEGAL PROTECTION OF INVENTIONS WITHIN MEDICAL PRACTICE
IN UKRAINE
Authors: Bezpalova Оlha I. , Yusupov Valeriy A. , Avramova Olha Ye. , Krasiuk Tetyana V. , Larina Nataliia B.
Published: October 2020

Introduction: There is a large number of patents registered in the field of medical practice in Ukraine. Despite this, the peculiarities of the legal protection of inventions within
medical practice have not been researched in the modern legal doctrine of intellectual property.
The aim of this article is theoretical and practical study of the legal protection of medical inventions in Ukraine based on the analysis of Ukrainian patent law, issued patents
for inventions applied within medical practice, as well as data from the State Expert Center of the Ministry of Health of Ukraine.
Materials and methods: The authors of the article have used methods of analysis and synthesis, as well as comparative and legal method. The analysis and further use of
data from the State Expert Center of the Ministry of Health of Ukraine contributed to the definition of the problems of this publication, as well as the formulation of the authors’
vision of the features of inventions within medical practice.
Review: Inventions within medical practice are the result of human intellectual activity in the field of medicine. The authors have offered to refer inventions within medical
practice to a group of inventions with a possible risk. The risks of inventions within medical practice are divided into those that have a risk for people undergoing clinical trials
and manufacturers who try to use these inventions.
Conclusions: The authors have grounded the expediency of supplementing the patent procedure with regard to inventions that can be applied within medical practice, with
the rule of obligatory provision of documents on conducting clinical trials to the materials of the application for a patent on the invention, in cases of restrictions of the rights of
a patent holder of medical and pharmaceutical inventions, by the provisions that would define the concepts and types of biotechnological inventions.
THE EFFECTIVENESS OF COMBINATED ANTIHYPERTENSIVE TREATMENT IN PATIENTS WITH ESSENTIAL HYPERTENSION OF THE II-ND STAGE DEPENDING ON THE TYPE OF DAILY BLOOD PRESSURE PROFILE AND THE TYPE OF REMODELLING OF THE LEFT VENTRICLE
Authors: Niushko Tetiana Y. , Tarasiuk Olena K. , Sikalo Yulia K.
Published: October 2020

The aim: To evaluate the dynamics of structural and functional parameters of the heart, vessels in patients with hypertension of the II-nd stage under the influence of combined antihypertensive treatment depending on the type of the left ventricle remodelling and the profile of blood pressure (BP).
Materials and methods: The study involved 110 patients with hypertension of the II-nd stage. The ambulatory blood pressure monitoring, echocardiography and Doppler examination of the shoulder arteries were performed. Initial treatment included bisoprolol, lisinopril, hydrochlorothiazide. With impossibility of BP lowering to the target level, amlodipine has been added.
Results: higher levels of BP in the “non-dipper” patients have led to the development of more pronounced changes in the heart and vessels compared with “dipper” patients. Three-component therapy was effective in patients with lower BP. The prescription of amlodipine has been found to be necessary for the majority of “non-dipper” patients and for the minority of “dipper”. Combined therapy effectively controlled the BP at the level of the target and contributed to a decrease in the displays of remodelling of the heart and blood vessels.
Conclusions: combined therapy used for 6 months reduces displays of disadaptive heart and vascular remodelling, diastolic, endothelial dysfunction. With the lack of efficacy of the therapy, which includes bisoprolol, lisinopril, hydrochlorothiazide, the adding of amlodipine to it can reach the target level of BP
SUBSTANTIATION AND DIFFERENTIAL APPROACH TO OPERATIVE TREATMENT OF PATIENTS WITH PSORIATIC ARTHRITIS
Authors: Burianov Olexandr A. , Kvasha Volodymyr P. , Sobolevskiy Yuriy L. , Stepanenko Roman L.
Published: October 2020

The aim: To improve the psoriatic arthritis treatment outcomes by establishing and implementing into practice operative treatment.
Materials and methods: The study basis is represented with the results of examination and treatment of 252 patients with psoriatic arthritis. The biopsy samples from the problem psoriatic eruption and intact skins regions, received from 74 patients, were studied.
Results: The study has established presence of Staphylococcus aureus in affected skin regions. The authors present their classification of structural muscular-skeletal disorders associated with psoriatic arthritis, which will substantiate the volume and character of operative interventions.
Conclusions: Detection of numerous opportunistic pathogenic microorganism colonies stipulates for the necessary skin debridement while planning further operative treatment, aimed at correction of anatomical and biological abnormalities. The operative intervention volume depends on the severity of structural dysfunctions.
EFFECT OF ENDOSTATIN AND INSULIN-LIKE GROWTH FACTOR-1 ON ANGIOGENESIS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION WITH OBESITY UNDER THE INFLUENCE OF ZOFENOPRIL
Authors: Martovytskyi Dmytro V. , Shelest Olexiy M. , Kravchun Pavlo G.
Published: October 2020

The aim: To study the dynamics of markers of angiogenesis based on insulin-like growth factor-1 (IGF-1) and endostatin, as well as to determine 6-month survival in patients taking zofenopril from the first day of AMI with and without obesity. Materials and methods: using enzyme immunoassay, we determined the level of endostatin and IGF-1 in serum on days 1 and 12 in patients with AMI with the presence and absence of obesity, and a statistical processing of the data obtained. Results: The relationship between obesity and angiogenesis indicators, both activators and inhibitors, was determined, and a significant relationship was found between zofenopril therapy and angiogenesis activator IGF-1. Differences in the survival of patients with complicated AMI were determined depending on the choice of ACE inhibitor in favor of a higher survival rate of patients who took zofenopril. Conclusions: patients who underwent complicated AMI, taking zofenopril, have a higher survival rate during the 6-month follow-up period. Zofenopril stimulated angiogenesis in the examined patients, which was expressed in patients with and without obesity.
AGE AND SEX-RELATED STRUCTURAL AND FUNCTIONAL CHANGES OF BONE REMODELING DURING SIMULTATE ABDOMEN CT-SCANNING
Authors: Kostyshyn Nazar M. , Kostyshyn Liubov P. , Gzhegotskyi Mechyslav R.
Published: October 2020

The aim of investigation was to study the structural and functional conditions of cortical and trabecular layers of lumbar vertebrae L1-L5 in different age groups.
Materials and methods: In order to assess BMD of the lumbar vertebrae 102 people18 to 75 years old was examined. Study of bone mineral density cortical and trabecular layer of lumbar vertebrae (L1-L5) performed by computed tomography in Hounsfield Units (HU) in terms of standard deviation (SD).
Results: The results of computed tomography showed a direct relationship of bone mineral density of lumbar vertebrae with age of examined persons. Osteoporosis and osteopenia was registered in 15% of men and 30% women in middle adulthood, in late adulthood – 35% and 50% respectively. During early old age osteopenia and osteoporosis are observed in 37,5% and 25% of men and 26% and 64% women. Osteoporosis in the middle old age has been reported in 50% of men and 75% of women Conclusions: Results of the study showed a direct link between mineral density, age and gender. The middle adulthood age period was characterized by the highest mineral mass compared with the other age periods. Then there is a loss of bone mass throughout life, and with the onset of aging osteopenia and osteoporosis are recorded. It was investigated that in the early old age, loss of bone mass is mainly observed in female.
PLACENTAL DYSFUNCTION: HEALTH STATUS, NUTRITIONAL STATUS AND MINERAL PROFILE OF A MOTHER-CHILD PAIR
Authors: Frolova Tetyana V. , Lazurenko Viktoriya V. , Pasiyeshvili Nana M. , Amash Anastasiia G. , Bilyi Yevhen Y. , Stenkova Nataliya F.
Published: October 2020

The aim: the analysis of the PD, pregnancy, the labor, the research on peculiarities of the development and health status of breast-fed children, who are born to mothers with PD, by means of analyzing the mother-child pair’s nutritional status and mineral homeostasis.
Materials and methods: At the 1 stage, an analysis of the PD frequency, the pregnancy, the labor was conducted during 5 years. At the 2 stage, 188 mother-child pairs were examined: 84.04% women had PD and 15.96% didn’t have it. The research included the analysis of the anamnestic data, maternal nutritional status, general clinical study, assessment of the physical, psychomotor level of the child’s development, study of the elemental profile.
Results: High frequency of complications in pregnancy and labor was observed in cases when women had PD, due to the imbalance in the “mother-placenta-fetus” system. The results’ analysis showed an increased level of Zn (1.437%), K (10.147%), and Ca (83.900%) in hair; an increased level of K (82.818%), Cr (0.274%), and Na (3.611%) in breast milk of women with PD. Children born to mothers with PD had a significantly increased level of Cr (0.92%), S (0.578%) and P (0.169%), Na (0.107%), Ca (56.041%), and Zn (7.149%).
Conclusions: PD has a negative impact on the pregnancy and labor and may be one of the factors causing the mineral imbalance of breast-fed infant.
PREVALENCE OF THE GENERALIZED PERIODONTITIS IN PATIENTS WITH DIFFERENT GROUPS BLOOD IN DEPENDING ON AGE AND PERIODONTAL BIOTYPE
Authors: Bandrivsky Yurii L. , Bandrivska Orysia O. , Shkrebnyuk Roksolana Yu. , Dyryk Volodimira T.
Published: October 2020

The aim of the study was to investigate the prevalence of generalized periodontitis depending on age and biotype of periodontium.
Materials and methods: We examined 855 males aged 20-55 years, who were divided into 2 groups: the main group – 570 surveyed with a generalized periodontitis, the comparison group – 285 dental healthy individuals.The diagnosis of generalized periodontitis was established by the classification Danilevsky M.F. (1994) and refined by using paraclinical indices. The periodontal biotype was determined using Hu-Friedy Colourvue Biotype Probe.
Results: As a result of the conducted researches was establish, in the carriers of blood group O (I) and A (II), developed forms of generalized periodontitis were found, on average, 2.7 times more often than the initial forms of the disease. Instead, at the representatives of B (III) and AB (IV) groups blood the frequency of initial GP – I degree was on average, 1.2 times greater than the prevalence of developed forms of generalized periodontitis. Also as a result of our researches, we found that the cluster A1 had 39.30% patients, cluster A2 was found at 28, 77%, and cluster B – 31.93% of the total number of patients with generalized periodontitis.
Conclusions: As a result of our research, it was found that in the carriers of the blood group O (I) and A (II), more advanced forms of generalized periodontitis were observed, which was confirmed by the presence of the biotype of the periodontal disease in the cluster A1 and A2.