bluuebunny/crossref_metadata_2025 huggingface dataset:
Impersonal Verbal Constructions in Biblical Hebrew: Active, Stative, and Passive
Authors: Notarius Tania
Published: January 2022

In this paper I focus on the syntactic properties of subjects in impersonal verbal constructions in Biblical Hebrew. It is claimed that four types of subjectless verbal clauses—active finite and participial plural, active finite singular, passive, and stative—feature three types of impersonal subject: covert indefinite pronoun, inflectional morpheme, and zero-subject. It will be demonstrated that these subjects have different, only partly overlapping syntactic properties: The covert indefinite pronoun implies an animate subject that does not necessitate “collective interpretation” and can have generic scope; the subject can be topicalised, negated, and relativised, the verbal predicate is temporally vague. The 3rd masculine plural inflectional morpheme implies an animate collective subject; it can be controlled from the matrix clause and be used for participant tracking and anaphora; the verbal predicate is quite precisely anchored in time. The dummy zero-subject has no explicit subject properties; it can be theorised that the syntactic slot of a subject is taken by an overt cognate argument (Cause or Theme) of stative or passive verbs, but practically such a subject leaves no syntactic traces.
Perwersyjny wymiar świętości, czyli o jurodiwych i nie tylko...
Authors: Lis-Wielgosz Izabela
Published: January 2022

In the article, the phenomenon of yurodstvo has been recalled, which is a characteristic and perhaps the brightest realization of the Eastern Christian ideal of sanctity as a clear projection of its irrational or even specifically perverse potential. The examples which are quoted in the considerations and selected from a rich literary corpus (Old Russian, Old Bulgarian and Old Serbian), are colourful manifestations of sanctity in Eastern Christian terms, which can be defined only in a specific religious or socio-cultural context. For that reason, it was considered that this specially designed sanctity should be interpreted in the key of negative theology which is typical of the Eastern (Orthodox) Christianity. Also known as apophatic, this theology assumes the impossibility of a positive knowledge of God, which entails a specific helplessness of reason towards the phenomenon that exceeds all applicable established standards. In the discussed case, the reflection intentionally goes beyond the limits of exemplification of the sainted yurodstvo, since it also covers other types of sanctity, recognized and perpetuated in the Eastern Christian (including Church Slavonic) tradition, and shows the proximity of all projections of the so-called parenetic sanctity along with the relationship between the yurodstvo itself and eremitism and  Monasticism. In this wide exemplification range, it seems justified that the incarnated sanctity of the yurodivy, a hermit or a monk, revealing itself in the socio-cultural reality in an unusual, incomprehensible or even perverse way, is an emanation of the numinous mystery which escapes the rational orders. This emanation should be, therefore, regarded as a phenomenon going beyond the boundaries of intellectual cognition, socio-cultural sphere, or a fixed standard.
ON THE ISSUE OF CREATING INCINERATED STRUCTURES FROM HIGH-ENERGY MATERIALS
Authors:   Omsk State Technical University, Omsk, Russia, Iordan Yu. V.
Published: January 2022

Представлены результаты исследований по утилизации головного обтекателя ракеты путем сжигания после выполнения миссии. Предложено заменить применяемые в настоящее время материалы на другие, обеспечивающие не только традиционные требования, но также сжигаемость на участке спуска. Показаны варианты конструкций заряда-заполнителя, определены их геометрические характеристики. Проведены экспериментальные исследования по сжиганию трехслойного элемента конструкции из выбранных материалов.
SOLVING PROBLEMS OF IMPROVING DEVICES FOR PROTECTING LARGE-SIZED OBJECTS FROM VIBRATION AND SHOCK
Authors:   Omsk State Technical University, Omsk, Russia, Korchagin A. V.
Published: January 2022

Актуальность настоящей работы обусловлена необходимостью совершенствования защиты объектов ракетно-космической техники от вибрации и ударов. Опыт разработки и использования подобных устройств показывает, что для виброзащиты крупногабаритных объектов предпочтительно применение пневматических виброизоляторов, в том числе с управляемыми упругодемпфирующими характеристиками. Цель настоящей работы - улучшение технических характеристик пневматических виброизоляторов с управляемыми упругодемпфирующими характеристиками. Задачи - улучшение массогабаритных показателей, демпфирующих свойств, повышение надежности пневматических виброизоляторов. Методы исследований: анализ, синтез, индукция, дедукция, аналогия, абстрагирование, конкретизация. Результаты начального этапа работы - разработан пневматический виброизолятор с улучшенными техническими характеристиками, выполнена численная проверка адекватности математической модели и получен патент на изобретение. В разработанном пневматическом виброизоляторе одновременно используются рукавные резинокордные оболочки, работающие на сжатие и растяжение, что обеспечивает решение поставленных задач. Вывод: решены задачи, являющиеся основанием для организации и проведения натурных экспериментов.
Immunocytochemistry of effusions: Processing and commonly used immunomarkers
Authors: Shidham Vinod B. , Janikowski Beata
Published: January 2022

Definitive cytopathological interpretation of some of the effusion fluids may not be possible based on cytomorphological evaluation alone. As discussed in other reviews, this is due to various reasons specifically applicable to effusion fluids including remarkably wide morphologic spectrum of reactive mesothelial cells overlapping with some well to moderately differentiated metastatic carcinoma. The challenge is subject to various factors including level of interpreter training or experience, institutional demographics (such as type of prevalent diseases, predominant sex and age group), technical advances in ancillary support, and expertise in cytopreparatory processing. In such cases immunohistochemistry performed on cell-block sections is simple objective adjunct with or without other ancillary techniques. Ongoing increase in number of immunomarkers along with rabbit monoclonal antibodies with relatively higher affinity is further refining this field. SCIP (subtractive coordinate immunoreactivity pattern) approach, discussed as separate dedicated review article, facilitates refined interpretation of immunoreactivity pattern in coordinate manner on various serial sections of cell-blocks. However, many variables such as delay after specimen collection, specimen processing related factors including fixation and storage; ambient conditions under which paraffin blocks are archived (for retrospective testing); antigen retrieval method; duration of antigen retrieval step; antibody clone and dilution; and antibody application time are common with application of immunohistochemistry in other areas. This review is dedicated to highlight technical aspects including processing of effusion specimens for optimum immunocytochemical evaluation along with commonly used immunomarkers in effusion cytopathology. This review focuses on the technical and general information about various immunomarkers.
Levonadifloxacin
Authors: Kalikar Mrunalini
Published: January 2022

Methicillin-resistant Staphylococcus aureus (MRSA) is one of the major public health concerns in India, MRSA infections continue to be therapeutically challenging both in hospitals and in the community. The currently available therapeutic options for MRSA are unable to provide safe and efficacious treatment with an option of oral switchover in the treatment of MRSA infections, especially in the community. Levonadifloxacin (LND) is a broad-spectrum benzoquinolizine fluoroquinolone with potent activity against quinolone-resistant S. aureus and MRSA phenotypes developed by an Indian company Wockhardt. LND and its oral prodrug alalevonadifloxacin have been recently approved in India for the treatment of acute bacterial skin and skin structure infections with concurrent bacteraemia and diabetic foot infections.
Estimation of Elevated Systolic Pulmonary Artery Pressure Using Right Ventricular Isovolumic Relaxation Time
Authors: Arke Avinash Dayalal , Babu P. Mahesh , Borkar Avinash Moreshwar
Published: January 2022

Objectives:

Echocardiographic estimation of pulmonary hypertension (PH) in absence of tricuspid regurgitation (TR) remains a challenge. Isovolumic relaxation time (IVRT) measured by Doppler tissue imaging (DTI) can be a useful method to estimate PH. This study was designed to evaluate the feasibility and accuracy of the right ventricle (RV) IVRT for predicting PH.

Material and Methods:

We conducted an analytical cross-sectional study in 90 consecutive patients suspected or known to have pulmonary hypertension (PH). sPAP was assessed using TR jet velocity using a Bernoulli’s equation. RV IVRT was calculated using tissue Doppler imaging.

Results:

Out of the 90 consecutive patients [49 (54.4%) were female, mean age was 48 +/- 14 years and mean systolic pulmonary aretry pressure (sPAP) was 68.25+/- 29.15 mmHg. Mean RV IVRT was 67.29 ± 22.2 msec. We found a strong correlation between IVRT and systolic pulmonary pressure (r = 0.69, P < 0.0001) and a cutoff of 43 ms showed a sensitivity and specificity of 89% and 93%, respectively, for the prediction of elevated sPAP (≥39 mm Hg). However, this correlation reduces in the presence of RV dysfunction and elevated mean RA pressure.

Conclusion:

The calculation of IVRT by DTI is a simple and feasible method. It correlates well with sPAP. It is a useful echocardiographic parameter as a screening in patients at risk for PH, monitoring the disease progression and the effect of the treatment for PH, especially in patients with absent TR.
Early Predictors of Success of Non-invasive Positive Pressure Ventilation in Hypercapnic Respiratory Failure
Authors: Parate Tilottama , Dhote Gayatri , Parate Ramesh
Published: January 2022

Objectives:

To study the indication of NIPPV in patients with hypercapnic respiratory failure. To evaluate the clinical, laboratory and ventilatory parameters with respect to improvement or deterioration in general condition of the patient. To predict the outcome in the form of weaning from NIPPV or requirement of invasive ventilation. To compare APACHE II score with outcome.

Background:

Non-invasive ventilation (NIV) is now being considered more as the respiratory support of choice for acute respiratory failure. In some patients, with acute hypercapnic respiratory failure, NIV is inadequate and invasive ventilation is required for the management of respiratory failure. Thus, the determination of early predictors of the success of non-invasive positive pressure ventilation (NIPPV) is important to identify the patients who are likely to benefit from it. This study was done to determine the early predictors of the success of NIPPV in hypercapnic respiratory failure.

Material and Methods:

In the current hospital-based prospective observational study, 100 patients admitted with hypercapnic respiratory failure requiring ventilation therapy are included in the study. Baseline clinical (heart rate [HR] and respiratory rate [RR]), arterial blood gas (ABG) parameters (pH, pO2, and pCO2), and ventilatory parameters were recorded before the initiation of NIPPV. The above parameters were re-evaluated at 1, 4, and 24 h after initiation of NIPPV. Acute Physiology and Chronic Health Evaluation II (APACHE II) score was also calculated on admission and at the end of 24 h to compare with the outcome.

Results:

Of the 100 patients, 73% of patients showed improvement in clinical and laboratory parameters. There was an improvement in HR, RR, pH, pCO2, and pO2 within the 1st hour and continued to improve even after 1 h, 4 h, and 24 h of NIPPV in the success group. About 27% of patients who failed to improve required intubation. The optimum cutoff value for APACHE II score on admission for predicting the outcome of NIPPV was found to be 33 in this study. Therefore, a score above 33 predicts failure of NIV.

Conclusion:

This study demonstrated that the clinical and laboratory parameters predict the success of NIPPV in patients with hypercapnic respiratory failure averting the need for mechanical ventilation.
Acute Myocardial Infarction in a Patient of Polycythaemia Vera
Authors: Khandait Vinod , Bhujle Sneha S. , Bagchi Nandita
Published: January 2022

Polycythaemia Vera is the most common form of myeloproliferative neoplasm.The median age of diagnosis is 60 years. Atherosclerosis is the most common cause of myocardial infarction, however other causes too should be looked for in the patients. Here, we present a case of 62 year old female who was a known case of hypertension and Ischemic heart disease on regular medications. She came with complaints of chest pain for the past 2 days. ECG showed NSTEMI with raised cardiac enzymes. She developed left side hemiparesis after admission, and the CT head showed acute infarct in right frontal lobe. She was started on treatment for NSTEMI and cerebrovascular event. Her CBC showed Hb-17.1g/dl, TLC-51600/mm3 and platelet count-625000/mm3, hence we suspected her to have polycythemia Vera with trilineage involvement. Serum erythropoietin was normal. JAK2(V617) profile was positive for homozygous (TT) mutation. Bone marrow biopsy findings were suggestive of trilineage hyperplasia. She was diagnosed as a case of polycythemia Vera. Our patient came into the age group wherein various risk factors for ischemic heart disease could be present like hyperlipidaemia, hypertension, diabetes mellitus but a careful look out for other causes too should be kept in mind.
Mechanical Negative Pressure Wound Therapy: Real-World Effectiveness in Challenging Patient Presentations
Authors: Swoboda Laura
Published: January 2022

Introduction. When used for wound management, negative pressure wound therapy (NPWT) delivers subatmospheric pressure at the wound site, exerting multiple beneficial effects, including microstrain, macrostrain, edema management, granulation tissue formation, drainage management, and wound stabilization. Comparative effectiveness research has demonstrated similar wound healing and adverse event outcomes between traditional NPWT (tNPWT) and mechanical NPWT (mNPWT). Therefore, considerations for patient selection for mNPWT vs tNPWT are in alignment with current recommendations, including therapeutic goals, wound-related factors, patient satisfaction, quality of life, care setting, economic-related factors, and product design. Case Reports. The 3 complex patient cases in the present report describe the routine use of mNPWT between December 18, 2020, and June 7, 2021, at a community hospital-based outpatient wound center within an academic health system, including 2 dehisced surgical incisions and 1 complicated venous leg ulcer. All patients received local standard of care, including surgical debridement, soap and water cleansing of the wound and extremity, hypochlorous acid 5-minute soak prior to dressing application, non-sting skin barrier periwound protection, smoking cessation and nutrition counseling, and chronic disease management. Case selections for mNPWT included: the need for frequent activity at work, minimal wound depth, lack of undermining, exudate, wound size, wound location allowing for the wound to fit comfortably beneath the mNPWT dressing, need for graft stabilization, protection of the site from repeated trauma, need for granulation tissue formation, and periwound inflammation. Conclusions. Mechanical NPWT is a convenient therapeutic option that appears to deliver healing outcomes comparable to those of tNPWT but with improved wound-related quality of life. These cases reveal the real-world effectiveness of mNPWT in challenging patient presentations and wounds that have stalled. The cases outline common endpoints for using advanced therapy in addition to wound closure, such as granulation tissue formation and quality of life.
The Requirement of Using Educational Platform in Educational Process from School Principals Perspective in Ajloun Directorate: متطلبات توظيف المنصات التعليمية الإلكترونية في العملية التعليمية من وجهة نظر مديري المدارس الحكومية في محافظة عجلون
Authors: Nadia Abdullah Altlab Wahsheh Nadia Abdullah Altlab Wahsheh
Published: January 2022

This Study aimed to identify the requirement of using educational platform in educational process from school principals perspective in Ajloun directorate, the researcher used the Descriptive approaches, study Sample consisted from (110) Female and male principals, chosen randomly, to collect data Questioner used, which consisted (24) paragraph Divided to three sector, the result of SPSS analysis shown that the degree of importance of the requirement of using educational platform in educational process from school principals perspective in Ajloun directorate was High, These requirements are "human" requirements and obtained the highest importance with an arithmetic average of "4.11", and "software technical structure" requirements with an arithmetic average of "4.00", then "technical" requirements with an arithmetic average, all of which are of high importance. The finding also showed there is no statistically significant differences at (α≤0.05) refers to principal sex (male and female) in addition there were statistically significant differences between the principals years of experience in favor of (less than 10 years). The researcher recommends the necessity of providing the infrastructure for employing electronic educational platforms for the teacher and student.
Availability of ergonomics requirements in Deanship of Library Affairs in Princess Nora bint AbdulRahman University: مدى توافر متطلبات بيئة العمل في عمادة شؤون المكتبات بجامعة الأميرة نورة بنت عبد الرحمن
Authors: Amjad Ibrahim ALHammad, Ahmed Mohammed Fathi Agwa Amjad Ibrahim ALHammad, Ahmed Mohammed Fathi Agwa
Published: January 2022

The recent study goals to determine the availability of the requirements of the field of work surroundings and its sub-axe, Organizational structure and training, and incentives and rewards, and technology - working conditions in Deanship of Library Affairs in Princess Nora bint AbdulRahman University. The researcher used the descriptive analytical method; the questionnaire was used as a tool to collect information and data related to this study. The results of the study were that the availability of the technology requirements axis, which came first among the axes of the work environment with an average of (3.83), an average indicates the availability of the technology requirements axis to a high degree, The availability of the training requirements axis which came in second place among the working environment axes with an average of (3.80) This is an average indicating a high degree of training requirements, Availability of the organizational structure requirements, which came in third place among the working environment with an average of (3.66) This is an average indicating the high level of organizational structure requirements, Availability of the requirements of the working conditions, which ranked fourth among the axes of the work environment with an average of (3.51) This is an average indicating the high availability of the requirements for working conditions, The availability of the incentive and rewards requirements axis which came in fifth place among the working environment axes with an average of (3.17) This refers to the average availability of the incentive and remuneration requirements. The study recommended the need to take into account the objectivity and the application of justice in the granting of incentives and rewards to employees, And The university administration should focus on the preparation of the incentive system accurately and clearly and work on linking with the performance of the employee and the productivity of work, and Encourage employees to present their new ideas and reward them morally and financially, and to provide all the necessary insurance for employees in the event of accident during the performance of their work.
The Role of Teaching Bridges Program in Developing Educational Process from The Point of View of Public School Principals in Ajloun Governorate: دور برنامج جسور التعلم في تحسين العملية التعليمية من وجهة نظر مديري المدارس الحكومية في محافظة عجلون
Authors: Hamzeh Abd Almajeed Mahmood Aluroad Hamzeh Abd Almajeed Mahmood Aluroad
Published: January 2022

This Study aimed to identify the role of teaching bridges program in developing educational process from the point of view of public school principals in Ajloun governorate, the researcher used the Descriptive approaches, study Sample consisted from (100) Female and male principals, chosen in an intentional stratified manner, to collect data Questioner used, which consisted (25) paragraph, the result of SPSS analysis shown that the degree of orate the role of teaching bridges program in developing educational process from the point of view of public school principals in Ajloun governorate was High with average (3.92 out of 5) , The finding also showed there is no statistically significant differences at (α≤0.05) refers to principal sex (male and female) in addition there weren’t statistically significant differences between the principals years of experience. According to the result a set of recommendation and suggestion to activate the Teaching Bridge to improve the in Ajloun Governorate schools and all of Kingdom and Arab countries.
The Level of Teaching Competencies for Mathematics Teachers of the Upper Basic Stage in the Directorate of Education of South Hebron: مستوى الكفايات التدريسية لدى معلمي رياضيات المرحلة الأساسية العليا في مديرية تربية جنوب الخليل
Authors: Ibrahim Moh’D Arman, Intisar Mahmoud Shahateet Ibrahim Moh’D Arman, Intisar Mahmoud Shahateet
Published: January 2022

This study aimed to identify competencies level of Mathematics teachers in Hebron governorate, The researchers adopted the descriptive methodology on a simple random sample, which included (175) teachers from both genders during the second semester in (2020/2021). The researchers built a questionaire to measure the teaching competencies of Mathematics teachers in Hebron governorate, consisted of (35) paragraph, the instrument validity and reliability was both verified, the reliability coefficient was (0.92). The results showed that the level of teaching competencies among Mathematics teachers for upper primary stage in Hebron governorate was high, with an average of (3.93), and standard deviation of (0.52). The results also revealed that there are no stasically significant differences in the teaching competencies among Mathematics teachers for upper primary stage in Hebron governorate due to the variables of gender, specialization, years of experience, and scientific qualification. In light of these results, the study recommends the necessity of adopting and strengthening all teaching competencies, holding training courses to familiarize teachers with new teaching methods, and conducting similar studies for various disciplines to give a more comprehensive perception of the reality of teachers’ performance and their possession of the necessary teaching competencies, and conducting studies to evaluate teachers’ performance from the students’ point of view.
The Role of PNA General Public Budget as A mean for Planning and Controlling in Rationalizing Financial Decision: دور الموازنة العامة للسلطة الفلسطينية كأداة للتخطيط والرقابة في ترشيد القرارات المالية
Authors: Mahmoud Gawdat Qabaha, Nael Adel Moussa Mahmoud Gawdat Qabaha, Nael Adel Moussa
Published: January 2022

The study aimed to identify the role of the Palestinian National Authority’s public budget as a tool for planning and control in making financial decisions, and the extent to which the PNA ministries and agencies rely on the budget as a tool for planning and control, and its role in rationalizing financial decisions, and to know whether there are difficulties facing decision-makers in ministries and agencies in the Palestinian National Authority limit the effectiveness of using budgets as a tool for planning and control and analytical approach was used for its suitability for the purposes of the study After collecting and analyzing secondary data, a questionnaire was designed as another tool for the study to answer the study questions and test its hypotheses. The questionnaire was distributed to a stratified random sample of 120 employees working in the ministries and authorities of the Palestinian National Authority. 104 questionnaires were retrieved, a percentage of A recovery amounted to (86.6%), which is a good percentage that satisfies the purposes of analysis, coming up with results and circulating them. One of the most important findings of the study is that the rationalization of financial decisions depends on control and not on planning, and that control has a fundamental role in following up the activities of the ministry or authority financially, which helps reduce the waste of public money allocated for the purposes of meeting the needs of public expenditures and some public service projects, as well as control on public revenues and strengthening its role in covering public expenditures. Based on these results, the study recommended the application of balancing programs and performance instead of balancing the applicable items, due to their relevance to a specific goal for each program. It also recommended holding periodic meetings for financial directors in each ministry or agency to study deviations in the budget and their causes, making feedback and increasing attention to human elements responsible for budget preparation and follow-up to develop professional and technical capabilities in using the general budget for better planning and control purposes through holding periodic meetings that contribute to deepening the dimensions of budget preparation.
The usage of psychometric equations in processing of master and doctoral theses in the Sudanese universities in the Khartoum – the capital, during (2015- 2020): استخدام المعادلات السيكومترية في معالجة رسائل الماجستير والدكتوراه في الجامعات السودانية بالعاصمة الخرطوم خلال الفترة (2015- 2020)
Authors: Abdalla Mohamed Abdalla, Omar Ibrahim Ahmed Abdalla Mohamed Abdalla, Omar Ibrahim Ahmed
Published: January 2022

This paper aimed to identify the use of psychometric equations (PE) in masters and doctoral theses that were defended at universities in Khartoum from (2015- 2020). The sample consisted of (n = 692) dissertations (Masters = 320, PhD = 372). The researchers used descriptive survey method, and designed a survey form. The researchers reached the following results: Order of use of PE: Cronbach’s alpha (α), Split- half coefficient, and factor analysis. There were differences in the use of PE according to the academic degree variable. There were differences in the use of PE in Masters according to the universities variable. The researchers put forward a number of recommendations including: The need to diversify the statistical indicators used in the interpretation of research results.
The Impact of Social Support for Women on Supporting Entrepreneurship for Saudi Women (An Empirical Study on the City of Abha): أثر المساندة الاجتماعية للمرأة السعودية في دعم ريادتها للأعمال (دراسة تطبيقية على مدينة أبها)
Authors: Areej Hassan Alsagoor, Amal Dafer Alamri, Amal Yahya Sultan, Areej Hassan Alsagoor, Amal Dafer Alamri, Amal Yahya Sultan,
Published: January 2022

The current study aimed to identify the impact of social support for women on supporting entrepreneurship for Saudi women, through: identifying the level of social support and the level of entrepreneurship among female entrepreneurs in the city of Abha. revealing the existence of a statistically significant correlation between social support and entrepreneurship among Female entrepreneurs in the city of Abha. revealing that there are statistically significant differences in social support and entrepreneurship among female entrepreneurs in the city of Abha due to the study variables (social status - age - number of children - qualification - type of activity). To achieve this goal, the study used the descriptive analytical method, and the questionnaire as a tool for data collection, and the study community represented all women entrepreneurs in the city of Abha, and a random sample of (409) women entrepreneurs in the city of Abha was chosen. The study reached several results, the most important of which are: The level of social support for female entrepreneurs in the city of Abha came to a medium degree. the level of application of the principles of entrepreneurship among female entrepreneurs in the city of Abha came to a large degree. the economic and social return of entrepreneurship projects came to a large degree. There is a statistically significant correlation between social support and entrepreneurship among female entrepreneurs in the city of Abha, there are no statistically significant differences between the responses of the study sample according to the variable of social status - age - number of children - qualification, while there are differences according to the variable type of activity in favor of agricultural category. the study recommends the necessity of spreading an entrepreneurial culture among Saudi women in a way that contributes to increasing the number of female entrepreneurs and contributes to enhancing the national economic and social return. the need to organize national initiatives to meet the needs of women entrepreneurs and work to solve the problems they face, and the need to pay attention to providing Advanced training programs on entrepreneurship and the areas needed by the Saudi labor market, which contribute to providing new entrepreneurial opportunities.
The Social Role of The Faculty of Educational Sciences as Perceived by Faculty Members at Jordan University: دور المسؤولية المجتمعية لكلية العلوم التربوية من وجهة نظر أعضاء هيئة التدريس في الجامعة الأردنية
Authors: Amira Yousef Thaher Amira Yousef Thaher
Published: January 2022

This study aimed at identifying the social role of the faculty of educational sciences by faculty at the UJ in 2021. To achieve this goal, a questionnaire is developed, which is consisted of four dimensions: Academic responsibility (teacher education), community responsibility, personal responsibility, and Community Research. The tool was distributed after verifying its validity and reliability to a randomly selected sample of 62 faculty members. The result was: the social responsibilities roles of educational faculty at JU of faculty members were high in four dimensions, with average 4.22 from 5.00. This indicates the importance of the role of faculty members in societal and social responsibilities. The results also indicated that there were no statistically significant differences attributed to the demographic variables of faculty members, except on the variable of academic rank at the dimensions of community and personal regarding professors. Also, the significant differences in dimensions academic, and community regarding faculty graduated from USA and Europe. Finally, the study recommended that: the ministry of higher education will establish an institutional work and give it great importance by adopting initiatives that serve the community in varies aspects. The College of Education should activate the role of social responsibilities in their programs and curricula.
Leadership patterns among public school principals and their relationship to the degree of improved job satisfaction from the point of view of teachers in Jordan: الأنماط القيادية السائدة لدى مديري المدارس الحكومية وعلاقتها بدرجة تحسين الرضا الوظيفي من وجهة نظر المعلمين في الأردن
Authors: Nesreen Khaled Alkailani Nesreen Khaled Alkailani
Published: January 2022

The study aimed to identify the leadership patterns prevailing among the principals of public secondary schools in the University/ Capital Brigade of Amman and their relationship to improving the level of job satisfaction among employees. The link and resolution survey descriptive approach was used as a study tool, whose sincerity and stability were confirmed. The sample was made up of 323 employees and employees of the State High Schools Brigade of the University/ Capital Amman for the 2021/ 2020 academic year selected in a random class manner. The results showed the prevailing leadership patterns in the following descending order (democratic leadership, positional leadership, autocratic leadership, strategic leadership, lenient leadership) , job satisfaction may provide satisfaction with the style of leadership and supervision well and showed satisfaction with the working environment to a moderate degree, and a strong positive relationship of job satisfaction with democratic leadership, positional leadership and strategic leadership, while the relationship of job satisfaction with the autocratic and lenient leadership was a negative relationship In addition, there are no statistically significant differences at the function level (α≤0.05) due to the variable of scientific qualification, and there are statistically significant differences at the function level (α≤0.05) due to the gender and age variables, the most prominent recommendations were the implementation of training programs to raise the awareness of leaders in leadership patterns, inform school principals of successful global experiences in order to follow up on developments and apply what is appropriate to us to maximize the benefit of educational outcomes, and continue to issue moral incentives to teachers.
Multiple Dural Arteriovenous Fistulas in the Superior Sagittal Sinus Region with Reversible Parkinsonism and Urinary Incontinence as Rare Presentations: A Case Report
Authors:   Department of Neurology, Peking University Shenzhen Hospital, China, W Yu , Y Huang ,   Department of Neurology, Peking University First Hospital, China, J Wu ,   Department of Neurology, Peking University Shenzhen Hospital, China, Y Li ,   Department of Neurology, Peking University Shenzhen Hospital, China, H Jin ,   Department of Neurology, Peking University First Hospital, China
Published: January 2022

Background: Dural Arteriovenous Fistula (DAVF), characterized by abnormally direct connections between meningeal arteries and meningeal veins or dural venous sinuses, is a rare subtype among the intracranial arteriovenous malformations. Although the clinical manifestations of DAVF are very variable depending on the locations and size of venous drainage, parkinsonism and urinary incontinence are rarely reported. Here, we present a rare case with parkinsonism and urinary incontinence secondary to DAVF. Case Presentation: A 50-year-old man was admitted for a progressively worsening weakness of his left lower limb over a year with urinary incontinence for four months. Neurological examination revealed rigidity and bradykinesia of the left upper limb without an obvious tremor. Magnetic resonance imaging exhibited diffuse white matter hyperintensities in bilateral centrum semiovale. Cranial magnetic resonance venography revealed extensive tortuous venous malformations. Digital subtraction angiography exhibited multiple bilaterally distributed DAVF in the superior sagittal sinus, supplied by bilateral occipital arteries and superficial temporal arteries. In the one year follow-up, the patient with multiple DAVF bilaterally distributed was completely cured after endovascular treatment according to the symptoms and the follow-up imaging results. Conclusion: This report enriches the clinical presentations of DAVF with parkinsonism and urinary incontinence, which is a crucial diagnostic clue to be aware of the possibility. Moreover, these rare symptoms can be relieved by timely endovascular treatment.
Factors Affecting Quality of Life in Patients with Chronic Respiratory Diseases
Authors:   Department of Public Health, Semmelweis University, Faculty of Medicine, Budapest, Hungary, M Fekete , ZS Szarvas ,   Department of Public Health, Semmelweis University, Faculty of Medicine, Budapest, Hungary, V Fazekas-Pongor ,   Department of Public Health, Semmelweis University, Faculty of Medicine, Budapest, Hungary, G Szollosi ,   Faculty of Public Health, University of Debrecen, Hungary, S Tarantini ,   Department of Biochemistry and Molecular Biology at University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA, JT Varga ,   Department of Pulmonology, Semmelweis University, Budapest, Hungary
Published: January 2022

Introduction: Chronic Obstructive Pulmonary Disease (COPD) is a progressive disease associated with worsening lung function, exacerbations and myriad factors affecting quality of life. Aim: Our cross-sectional study aims was to assess the quality of life of COPD patients and its determinants. Methods: 200 COPD patients aged over 40 years completed our questionnaire in Budapest at the Department of Pulmonary Rehabilitation of the National Koranyi Institute of Pulmonology between September 1, 2019 and March 1, 2020. We used the disease-specific COPD Assessment Test (CAT) questionnaire to measure quality of life, furthermore the Morisky Medication Adherence Scale (MMAS) to measure patients’ medication adherence. Results: The median age of patients was 67 years, with a sex ratio of 48.0% male and 52.0% female. Malnourished patients (n=44) had a significantly lower quality of life (CAT: 27 vs. 25; p=0.046) than normal or overweight patients. Vitamin D is taken regularly by 27.0% of patients (CAT: 25.0 vs. 26.5; p=0.049), while omega-3 fatty acid is taken by 5.0%, also with improved quality of life. There was a significant difference in quality of life indicators between patients who cooperated (69.0%) and those who did not (31.0%). Patients’ education level, smoking status, influenza-, pneumococcal vaccination and physical activity also played a role in patients’ quality of life. Conclusion: Patients with COPD have low quality of life indicators due to their disease, which is influenced by a myriad of factors. Professionals, who treating patients, need to take these factors into account in order to improve the effectiveness of treatment.
Female Genital Tuberculosis Can Cause Infertility in Women or Not?
Authors:   Student Research Committee, Jahrom University of Medical Sciences, Jahrom, Iran, N Shaterian
Published: January 2022

One of the important issues is infertility that is increasing today and the causes are various. Bacterium Tuberculosis is viable in pulmonary and extrapulmonary [1]. Female genital tuberculosis is an extrapulmonary type that makes up 9% of the cases [1]. Tuberculosis infection of the female genitalia leads to secondary infertility, dyspareunia, amenorrhea, irregular menstruation, and chronic pelvic inflammatory disease [2]. In 90% of cases, female genital tuberculosis affects young women aged 18 to 38 years old [3]. The global prevalence of female genital tuberculosis in infertile women is about 5% to 10% [2]. Hence, it should be considered as a differential diagnosis of the infertility causes in areas with tuberculosis infection prevalence. The gold standard method for diagnosis of this bacterium is culture, but the minimum number of bacteria should be 10-100 bacilli per milligram in this method [4]. Moreover, its long incubation period in this method leads to delays in diagnosis and treatment [4]. Also, laparoscopy can be used for diagnosis. Both laparoscopic and molecular tests are complementary tests and together they can effectively confirm the diagnosis of female genital tuberculosis [4]. For the treatment of female genital tuberculosis, multidrug therapy with rifampicin, isoniazid, pyrazinamide, and ethambutol is used, while in more severe cases, surgery is recommended [5]. However, even after using multidrug therapy, infertile women with genital tuberculosis are less likely to be fertilized, and if they do become pregnant, the consequences of pregnancy such as ectopic pregnancy or miscarriage remain high [5]. Since, untreated tuberculosis causes extrapulmonary tuberculosis, preventative measures such as BCG vaccination at birth, identification of people with tuberculosis, early diagnosis, and treatment of tuberculosis can prevent extrapulmonary tuberculosis [2]. Therefore, similar to any other disease and infection, the best way to treat and reduce this infection and then reduce the rate of infertility is to diagnose and treat it early.
To Study the Practices and Life Style Skills Management and Its Impact among Diabetic Patients to Prevent Its Complications in the Field Practice Area of Government Medical College, Amritsar
Authors:   Senior Resident, Dr. B.R Ambedker State Institute of Medical Sciences, Mohali, India, A Soni
Published: January 2022

Aims: 1) To assess the regularity to check the RBS and treatment among diabetic patients (>10 years). 2) To assess the life style skills management among Diabetics (>10 years). 3) To study the impact of practices and life style skills management among Diabetics (>10 years). Settings and Design: A community based cross-sectional study was conducted in rural and urban field practice areas of Government Medical College, Amritsar. Methods and Materials: A total of 200 diabetic patients who had diabetes equal to or more than 10 years of duration were interviewed using pretested and predesigned questionnaire. Results: Out of 200 respondents, 50% (100/200) were from urban area and 50% (100/200) were from the rural area. Out of total, 65(65%), 86(86%) diabetic respondents from rural and urban areas were on regular treatment (p<0.05) and 28(28%), 68(68%) diabetic respondents from rural and urban areas had glucometer, from which 39(39%), 57(57%) diabetic respondents from rural and urban areas checked their RBS regularly (P<0.05). Out of total, 2(1%) respondents were doing physical activity before and 53 (26%) after the disease. 1(1%) had quit smoking before and 2 (1%) after the disease and 2(1%) had avoided selected food items before and 134(67%) after the disease. Out of total 47 diabetic respondents who were without complications -20(95%), 24(92%) from rural and urban areas were doing life style modifications, R-19(90%), U-25(96%) were on regular treatment.R-18(86%), U-24(92%) were doing regular check up and R-18(86%), U-26(100%) were monitoring blood glucose level on regular basis. Conclusions: The practice to check the RBS on regular basis and regular treatment and life style skill management was poor among diabetic patients which leads to development of complications at early stage among diabetics (>10 years).
CAR T Cell-Packaged Oncolytic Vaccinia Virus Displays Enhanced Antitumor Efficacy
Authors:   cell Kealex Therapeutic, Houston, JLABS, 2450 Holcombe Blvd, Houston, TX, USA, Song Kevin , Wang Xingbing ,   Center for Cell and Gene Therapy, Baylor College of Medicine, One Baylor Plaza, Houston, TX, USA
Published: January 2022

Background: Oncolytic vaccinia virus is a promising cancer therapeutic modality. However, the effectiveness of oncolytic viruses is limited by several factors. Systemic or intratumoral delivery of vaccinia viruses with the subsequent quick clearance of the viruses from the tumor site and the body by the strong immune responses induced by the virus are among the key challenges. In this study, we explored CAR T cell-packaged oncolytic vaccinia virus as a combinational therapy strategy in order to overcome current limitations for oncolytic virotherapy. Materials and Methods: We generated human HER2-CAR T cells and infected the HER2-CAR T cells with a EphA2-CD3 T cell engager-armed oncolytic vaccinia virus and evaluated the virus infectivity and replication within the T cells by flow analysis and virus tittering. T cell activation and cytotoxicity were determined by ELISA and 51Cr release assay. Results: We demonstrated that oncolytic vaccinia virus infected human HER2-CAR T cells effectively and virus particle in the activated human T cells increased >1000 fold in 3 days. In addition, EphA2-CD3 T cell engager effectively activated HER2-CAR T cells in the presence of HER2dimEphA2high NSCLC A549 cell lines, indicated by the elevated expression level of IFNγ and IL2. Importantly, in vitro studies showed that HER2-CAR T cell-packaged EphA2-TEA-VV displayed enhanced cytotoxicity against HER2dimEphA2high NSCLC A549 cell lines compared to HER2-CAR T cells or EphA2-TEA-VV alone. Conclusion: HER2-CAR T cell-packaged EphA2-TEA-VV is a promising therapeutic candidate with the ability to overcome the virus’s high immunogenicity and tumor heterogeneity, resulting in enhanced antitumor effects.
Impedance Eye Recording IER: A New Glaucoma Diagnostic Tool?
Authors:   University Eye Clinic, FMH ophthalmologist, Lausanne, Switzerland, PA Grounauer , MV Moreno ,   Biomedical Engineering, CEO Runsys, Lyon, France, C Houriet ,   HES engineer, CEO Fabrinal SA, La Chaux-de-Fonds, Switzerland
Published: January 2022

Described in 1941 by two New Yorker physicist brothers, KS Cole et RH Cole, who propose and publish together a new mathematical equation plotting polymers’ electrical reactance/resistance correlation, Rea/Res, named the Cole-Cole curve [1]. Since then, this method is used to know how sinusoïdal current goes through living tissues, be they vegetable or animal. Applied on the human body it is included in weighing machines to adapt sports training, for example. In medicine to evaluate many organs like lungs, breast [2] or skin tumours, heart and brain or to separate normal from tumoral cells. In Clinical Ophthalmology to our knowledge, they are not yet similar papers. At the present time PubMed, key words are for first eye impedance or eye and clinical impedance spectroscopy, in August 2021, 22 references without strict IER correlations and then none. Closest publications are Fukuda [3] to quantify corneal defects, Jürgens [4] about in vitro eye impedance and CA Gutierrez [5] about lens hydratation. In the University Eye Clinic electrophysiology lab, Lausanne Switzerland, together with MVM [6] and Fabrinal [7] we have modified the ERG-Jet (electroretinogram) contact lens from an electric retinal captor to an emitting electrical injector, thus describing and creating sure IER scientific basic data to obtain acceptable impedance ocular signal/noise recordings. Our first results show this method is easy to use, quick and without discomfort. Furthemore we found Rea/Res age-dependent [8]. Now we are in the process of collecting normal IER values on healthy young people to evaluate sensitivity then specificity. In the recent Springer paper [9] we describe a phantom glaucoma model to simulate extra/intra cell water concentrations in the ocular anterior chamber. Therefore, we found this pilot study a good predictive model. That is the reason why we presume that this relatively new IER providing Cole-Cole ocular curve can probably be a useful complementary tool to understand glaucomas and/or other ophthalmic diseases where extra/intra cell water concentrations are abnormal.
Catalytic Addition of Nitroalkanes to Unactivated Alkenes via Directed Carbopalladation
Authors: Simlandy Amit , Rodphon Waraborn , Ni Hui-Qi , Gurak John , Engle Keary
Published: January 2022

We report a redox-neutral catalytic coupling of nitroalkanes and unactivated alkenes that proceeds by a directed carbopalladation mechanism. The reaction is uniquely enabled by the combination of PdI2 as the precatalyst and HFIP solvent. Structurally complex nitroalkane products, including nitro-containing carbo- and heterocycles, are prepared under operationally convenient conditions without the need for toxic or corrosive reagents. Deuterium labeling experiments and isolation of a catalytically relevant intermediate shed light on the reaction mechanism. By taking advantage of different catalytic activation modes, we demonstrate orthogonal methods for site-selective functionalization of a polyfunctional nitroalkyl ketone.