bluuebunny/crossref_metadata_2025 huggingface dataset:
Time on opioid agonist therapy predicts HCV treatment uptake in people who use drugs: a historical cohort based on French national healthcare database, 2012-2017 (the ANRS FANTASIO project)
Authors: ROLLAND Benjamin , Lions Caroline , Beo Vincent Di , Carrieri Patrizia , Authier Nicolas , Barré Tangui , Delorme Jessica , Mathurin Philippe , Bailly François , Protopopescu Camelia , Marcellin Fabienne
Published: May 2022

Background
Opioid Agonist Treatments (OAT), i.e., methadone and buprenorphine, are key elements in the treatment of opioid addiction. Moreover, they help foster healthcare behaviors and reduce medical harm in people who use opioid drugs (PWUD). Here, aimed to explore whether the percentage of time on OAT (pOAT) among PWUD with hepatitis C virus (HCV) was significantly associated with an increased uptake of direct antiviral agents (DAA). In France, 80% of PWUD have more or less regular deliveries of OAT, and OAT recipients are good proxy for PWUD.
Methods
Using the quasi-exhaustive French nationwide healthcare system database, we included all French individuals with chronic HCV receiving at least one OAT dispensing between 1 January 2012 and 31 December 2016. Subjects already treated by DAA at the time of first OAT delivery were excluded. The initiation of DAA during the study period was modeled using pOAT, which was computed as the number of days covered by OAT delivery, divided by the number of days of the study period of each participant. A Cox proportional hazards model allowed us to estimate the association between pOAT and DAA uptake (defined as the first delivery of treatment) during the study period, after adjustment for age, gender, alcohol use disorder, precarity indicator, and liver disease severity, respectively.
Results
Among the 22,615 persons included in the study, 3,438 (15.2%) had at least one dispensing of DAA during the study period. After multivariable adjustment, pOAT was associated with increased DAA uptake (adjusted hazard ratio [95% confidence interval]: 1.02 [1.01–1.04] per each 10% increase, p = 0.001). Other variables associated with DAA uptake were male sex, older age, cirrhosis or liver cancer, and higher socioeconomic status.
Conclusions
DAA uptake in PWUD with chronic HCV is associated with a greater pOAT uptake. Fostering compliance to OAT, and expanding the use of entry points for OAT as entry or referral points for DAA initiation should be integrated into the strategies for eliminating HCV and reducing harms related to this virus.
Supervisor experiences of extended clinical placements in optometry: A mixed methods study
Authors: Kirkman Jacqueline M , Bentley Sharon A , Wood-Bradley Ryan J , Woods Craig A , Armitage James A
Published: May 2022

BackgroundIn Australia, optometry students have traditionally undertaken their clinical training in short-block rotations at University-led teaching clinics in metropolitan locations. Demand for clinical placements is growing as the number of optometry students steadily increases. As such, universities and clinical education providers must look for more diverse methods of student placement. Extended clinical placements in community-based settings are one alternative: a model similar to the longitudinal clerkships in medicine. This study aimed to explore the experience of extended clinical placements from the perspective of the optometrists who supervised students. It also sought to determine whether there were differences in views between metropolitan and rural practitioners.MethodsThis mixed methods study included a survey and interviews with optometrists who had previously supervised Deakin University optometry students on an extended 26-week (2 x 13-weeks) clinical placement. Lines of enquiry focused on; the benefits and challenges associated with extended placements; areas for improvement; duration of the placement; and willingness to supervise further students. Interviews were transcribed verbatim and analysed using Braun and Clarke’s 6 step method of thematic analysis with a qualitative descriptive approach. ResultsSupervisors felt that hosting a student prompted greater reflective practice and critical appraisal of clinical decisions. The extended nature of the placement was thought to foster greater immersion in the clinical setting and community for the students and establish a stronger relationship between supervisor and student. Supervisors recognised the importance of role-modelling and mentoring the next generation of optometrists however noted that taking on a student was a sizeable commitment. Willingness to host a student was not dependent on the supervisor’s location (rural vs metropolitan) p = 0.57. However, interviews uncovered motivations that were unique to supervisors residing in rural locations, such as succession planning.ConclusionOverall, supervisors were positive about the value of student extended clinical placement in optometry and felt that it was a fulfilling and professionally beneficial experience. Lack of time and financial remuneration were the key downsides highlighted. Schools of optometry might carefully consider engaging in discussion about the duration of such placements, but 26 weeks was considered appropriate by supervisors.
Non-obese non-alcoholic fatty liver disease is correlated with type 2 diabetes in Chinese adults
Authors: Wei Xiaohui , Ding Xiaoying , Wang Xuejiao , Tang Min , Cao Han , Dong Weiping , Peng Yongde , Fan Nengguang
Published: May 2022

Background: Nonalcoholic fatty liver disease (NAFLD) in non-obese individuals (non-obese NAFLD) is correlated with multiple metabolic abnormalities, while its relationship with type 2 diabetes has yet to be fully evaluated. Therefore, we investigated the relationship between non-obese NAFLD and type 2 diabetes in Chinese adults. Methods: This was a cross-sectional study involving 2037 non-obese individuals ( body mass index（BMI）＜25kg/m2). Clinical parameters were determined while the diagnosis of NAFLD was done by ultrasonography. Results: The non-obese NAFLD prevalent in the present study was 15.6%. Non-obese NAFLD patients had elevated BMI, blood pressure, triglycerides (TG), blood glucose, low-density lipoprotein cholesterol (LDL-C) and insulin resistance levels than those without NAFLD. Furthermore, the incidence of type 2 diabetes was markedly elevated in the non-obese NAFLD group, relative to control group (29.7% and 11.2%, respectively). After adjustment of confounding factors (age, BMI, sex, lipid profiles, blood pressure and insulin resistance), the odd ratio (95% CI) for diabetes were 2.37 (1.69–3.31) in non-obese NAFLD group. Subgroup analysis showed that sex, age, BMI and TG did not change the association between type 2 diabetes and non-obese NAFLD. Conclusions: Non-obese NAFLD is closely related with type 2 diabetes independent of other metabolic factors.
Ovarian colorectal metastases: peritoneal or hematogeneous metastatic disease?
Authors: Leimkühler M. , Hemmer P.H.J. , Werner N. , de Hingh I.H.J.T. , Mourit M.J.E. , Hollema H. , de Bock G.H. , Leeuwen B.L. van
Published: May 2022

PurposeThere is an ongoing discussion whether ovarian colorectal metastases are the result of peritoneal or hematogeneous dissemination. The metastatic route has implications on the choice of treatment. This study aims to evaluate and discuss the factors indicating peritoneal or hematogenic dissemination and aims to evaluate and discuss the factors indicating peritoneal or haematogenic spreadMethodsA retrospective consecutive series of patients from two tertiary referral centers, who were treated for ovarian metastases from colorectal cancer between 2000 and 2018, was described. Clinical and histopathological characteristics of the primary tumor and the ovarian metastases were collected from patient files, the surgery reports and the pathology files. Statistical analysis included descriptive statistics, whereas binominal testing was used to compare the likelihood of two categories.ResultsData of 141 patients were included. In most cases the ovarian capsule (73.6%) was broken and 120 patients (85.1%) had peritoneal metastases at the time of diagnosis of the ovarian metastases. Most metastatic cells were found deep in the ovarian stroma (80.0%) and 26.2% of patients developed metachronous hematogeneous (distant and/or liver) metastases. ConclusionsIn this study we found characteristics that support a peritoneal as well as a hematogenous dissemination. Therefore, an undoubted conclusion regarding the metastatic route cannot be drawn. Future studies should focus on the biological behavior as well as on the outcome of patients with ovarian metastases after CRS+HIPEC to evaluate its added value in this patient group.
Migraine as the sole manifestation of non-coeliac gluten sensitivity
Authors: BUGNICOURT Jean-Marc
Published: May 2022

BackgroundMigraine is a well-known extra-intestinal symptom of non-coeliac gluten sensitivity (NCGS). To date, it has been always associated with the gastrointestinal signs and symptoms of NCGS.Case presentationHere, we report on two patients with a long history of migraine as the sole manifestation of NCGS. Their response to a gluten-free diet was excellent.ConclusionsIn conclusion, clinicians should be aware that migraine can be the sole manifestation of NCGS patients. Given the growing prevalence of NGCS, these findings raise the question of whether all migrainous patients should be screened for NGCS.
Association between Anatomical Variations of the Circle of Willis and Covert Vascular Brain Injury in the General Population
Authors: Feng Lu , Zhai Fei-Fei , Li Ming-Li , Zhou Li-Xin , Ni Jun , Yao Ming , Jin Zheng-Yu , Cui Li-Ying , Zhang Shu-Yang , Han Fei , Zhu Yi-Cheng
Published: May 2022

Background and Purpose: The circle of Willis (COW) is a circulatory anastomosis located at the base of the brain. Little is known about the association between covert vascular brain injury and COW configurations in the general population. We explored this relationship in a community-based Chinese sample.Methods: A total of 1055 patients (mean age, 54.8 ± 8.9 years; 36.0% men) without intracranial arterial stenosis were included in the analysis. Magnetic resonance imaging was performed to evaluate the presence of imaging markers of covert vascular brain injury, including white matter hyperintensities (WMHs), lacunes, cerebral microbleeds (CMBs), enlarged perivascular spaces, and brain atrophy. Magnetic resonance angiography was used to classify the COW configurations according to the completeness, symmetry, and presence of the fetal posterior cerebral artery (FTP). The association between vascular lesions and variations in COW was analyzed. Results: Among the 1055 patients, 104 (9.9%) had a complete COW. Completeness correlated with age (p=0.001). Incomplete COW was positively associated with WMH severity (OR=2.071; 95% CI, 1.004–4.270), and CMB presence (OR=1.542; 95% CI, 1.012–2.348), independent of age and sex. The presence of FTP was associated with lacunes (OR=1.878; 95% CI, 1.069–3.298), more severe WMHs (OR=1.739; 95% CI, 1.064–2.842), and less severe enlarged perivascular spaces (OR=0.562; 95% CI, 0.346–0.915). Conclusions: COW configuration was significantly related to various covert vascular brain injury.
Recombinant LH supplementation improves cumulative live birth rates in GnRH antagonist protocol: a multi-center retrospective study using a propensity score-matching analysis.
Authors: Wang Meng , Huang Rui , Liang Xiaoyan , Mao Yundong , Shi Wenhao , Li Qian
Published: May 2022

Background: Luteinization hormone (LH) is critical in follicle growth and oocyte maturation. However, the value of recombinant-LH (r-LH) supplementation to recombinant-follicle stimulation hormone (r-FSH) during controlled ovarian stimulation in Gonadotrophin releasing hormone (GnRH) antagonist regimen is controversial. Methods: The multicenter retrospective cohort study recruited 899 GnRH antagonist cycles stimulated with r-LH and r-FSH in 3 reproductive centers, and matched to 2652 r-FSH stimulating cycles using propensity score matching (PSM) for potential confounders in a 1:3 ratio. The primary outcome was the cumulative live birth rate (CLBR) per complete cycle.Results: The baseline characteristics were comparable in the r-FSH/r-LH and r-FSH groups after PSM. The r-FSH/r-LH group achieved higher CLBR than the r-FSH group (66.95% VS 61.16%, p=0.006). R-LH supplementation also resulted in higher 2-pronuclear embryo rate, usable embryo rate, live birth rate in both fresh embryo transfer cycles and frozen-thawed embryo transfer (FET) cycles. No significant differences were found in the moderate and severe ovarian hyperstimulation syndrome (OHSS) rate, and cycle cancel rate in prevention of OHSS.Conclusions: R-LH supplementation to r-FSH in GnRH antagonist protocol was significantly associated with higher CLBR, live birth rate in fresh and FET cycles, and improved embryo quality without increasing OHSS rate and cycle cancel rate.
Optimization of Anti-vortex Blades Geometry in Morning Glory Spillways by Numerical simulation
Authors: Chitsazan Mohammad , Ghafouri Hamid Reza
Published: May 2022

Dam spillway is a structure that discharges destructive excessive water, especially during floods, to downstream river. In some cases where limited space is available, morning glory spillway is used. This type of spillway is made up of a funnel-shape inlet, an inclined or vertical shaft, a 90-degree vertical bend, and an outlet conduit or tunnel. The main problem associated with morning glory spillway is the creation of strong vortices in the spillway inlet. One of the effective methods in controlling the vortices is the use of anti-vortex blades (piers) which are used to increase the discharge coefficient and spillway efficiency. The aim of this research is to find the best arrangement of Anti-vortex Blades in four different scenarios numerically using computer simulation. Each case was examined against four different flow rates of 160, 200, 240, 280 m 3 /s. The options with the highest discharge coefficient were considered as the best options for each discharge rate. In the next stage, in order to investigate the impact of higher water rates, the best options obtained for each discharge rate in the previous stage were also examined for the higher discharges of 320 and 400 m 3 /s. It was found out that among the 112 different blade arrangements, employing 12 blades with a length of 8 meters decreases the water head and increases the discharge coefficient up to 0.53 and 5.58 times, respectively, Also employing 2 blades each having a crest slope angle of 0° between the spillway crest and throat decreases the water head and increases the discharge coefficient up to 0.528 and 5.447 times, respectively. Given that both arrangements of Anti-vortex Blades have almost the same results in reducing the water head and also increasing the spillway discharge coefficient, the use of 2 blades each having a crest slope angle of 0° between the spillway crest and throat is very economical and it is therefore the optimum arrangement of blades.
Nivolumab plus ipilimumab in metastatic uveal melanoma: a real-life, retrospective cohort of 47 patients
Authors: Salaun Helene , de Koning Leanne , Saint-Ghislain Mathilde , Servois Vincent , Ramtohul Toulsie , Garcia Agathe , Matet Alexandre , Cassoux Nathalie , Mariani Pascale , Piperno-Neumann Sophie , Rodrigues Manuel
Published: May 2022

Introduction: Although combined PD-1/CTLA-4 inhibition showed limited efficacy in single-arm, phase II trials in metastatic uveal melanoma (mUM), such combination appears frequently used in mUM patients. We here report our experience with nivolumab/ipilimumab in mUM.Materials and methods: Retrospective cohort of mUM patients treated with nivolumab/ipilimumab. Results: Forty-seven mUM patients, 24 men and 23 women, received nivolumab/ipilimumab between October 2019 and December 2021 mostly first-line (94%). Two regimens were used: nivolumab 1 mg/kg + ipilimumab 3 mg/kg (nivo1ipi3, 49% of patients) and nivolumab 3 mg/kg + ipilimumab 1 mg/kg (nivo3ipi1, 51% of patients). Median follow-up was 37 and 88 weeks in nivo3ipi1 and nivo1ipi3 cohorts, respectively. We observed partial response in two patients (4%) and stable disease in 14 patients (30%), with no significant difference between the two regimens. Median progression-free survival was 13.6 weeks and 11.9 weeks in the nivo1ipi3 and nivo3ipi1 cohorts respectively (p = 0.49). Severe adverse events (grade 3 or 4) were observed in seven patients (15%) among which five treated with nivo1ipi3 (22%) and two treated with nivo3ipi1 (8%). Conclusion: Nivolumab/ipilimumab did not improve PFS compared to PD-1 inhibition monotherapy in historical cohorts but was more toxic. In the absence of controlled clinical trials, we would not recommend this combination as a standard treatment in all mUM patients but rather as an option. Patients for whom the benefit-risk ratio could justify the combination need to be defined.
Role of computed tomography severity score as a predictor of disease severity and mortality in COVID-19 patients: a systematic review and meta-analysis
Authors: Prakash Jay , Kumar Naveen , Yadav Arun Kumar , Saran Khushboo , Kumar Amit , Bhattacharya Pradip Kumar , Prasad Anupa , Ekka Nishith M Paul , Priye Shio
Published: May 2022

Purpose: Coronavirus disease 2019 (COVID-19), a highly contagious disease, has expanded fast over the world and continues to pose a serious threat to global public health. The prognosis for patients identified with severe or critical cases is bleak. As a result, it's vital for us to spot potentially serious or critical instances early on and treat patients as soon as possible. In the clinical practice of treating patients with COVID-19, we have observed that the computed tomography severity score (CTSS) of severe patients is higher than that in mild patients. We performed this systematic review and meta-analysis to evaluate the predictive values of CTSS on disease severity and mortality in patients with COVID-19.Methods: We searched electronic databases such as PubMed, Google Scholar, Web of Science, and the Cochrane Library to identify eligible studies (up to June 15, 2021). Two authors independently and repeatedly screened all possibly important citations and references in two phases, first reviewing titles and abstracts and thereafter completing manuscripts for those which qualified the parameters. Disagreements were settled by a third author. We used the Quality In Prognosis Studies (QUIPS) tool to assess the risk of bias independently and in duplicate in studies of prognostic factors. The protocol for our systemic review was prospectively registered on PROSPERO (CRD42021244069).Results: Twenty studies involving 3002 patients reported the predictive value of CTSS on disease severity. The pooled sensitivity and specificity were 0.85 (95% CI 0.79–0.90, I2 =81) and 0.87 (95% CI 0.78–0.92, I2 =95), respectively. The summary area under curve (sAUC) of CTSS for predicting disease severity was 0.92 (95% CI 0.89–0.94). A total of ten studies were included for predictions of the mortality on the basis of CTSS and1784 patients were enrolled. The pooled sensitivity and specificity were 0.76 (95% CI 0.70–0.81, I2 = 28.5) and 0.79 (95% CI 0.74–0.84, I2 = 80.5), respectively. The sAUC of CTSS for predicting mortality was 0.84 (95% CI 0.81–0.87).Conclusion: CTSS has good discriminating power for the prediction of disease severity and mortality in patients with COVID-19. Evaluating CTSS can assist clinicians to become aware of potentially severe cases early, conduct early triage and initiate effective control in time, which may also lessen the mortality of COVID-19.
Association Between Dietary Phosphorus Intake and Chronic Constipation in Adults: Evidence from the National Health and Nutrition Examination Survey
Authors: Zhao Xuelian , Wang Lizhu
Published: May 2022

Background: Several studies suggest a link between micronutrients and constipation. However, the relationship between constipation and phosphorus has rarely been examined. Consequently, the main aim of this study was to investigate the link between changes in the prevalence of chronic constipation and changes in dietary phosphorus intake among adults in the NHANES (National Health and Nutritional Examination Survey).Methods: Data were extracted from the NHANES database from 2005–2010. In total, after inclusion and exclusion, 13 948 people were included in the analysis. Dietary information was collected using the respondents’ 24-hour dietary records. We conducted several multiple logistic regression analyses to examine the correlation between phosphorus intake and poor bowel movement. Results: After multi-variate adjustment in model Ⅲ, there was a statistically significant association between chronic constipation and each additional 0.1 g intake of dietary phosphorus (odds ratio (OR), 0.97; 95% confidence interval (CI), 0.95, 1.00; P=0.034 for stool consistency vs OR, 0.94; 95% CI, 0.90, 0.99; P=0.027 for stool frequency). After multi-variate adjustment in model Ⅲ, OR values and 95% CI from the second to fourth quartiles compared to the first quartile (reference group) were 0.92(0.66, 1.27), 0.73(0.47, 1.13), and 0.39(0.20, 0.76), respectively.Conclusions: This study revealed a negative correlation between phosphorus intake and chronic constipation. Further studies in different settings should be considered to verify these findings.
Learner Performance-based Behavior Optimization Algorithm: A Functional Case Study
Authors: Shahad  , Rashid Tarik A.
Published: May 2022

A novel algorithm called learner performance-based behavior algorithm (LPB) was proposed for single and multi-objective by Chnoor M. Rahman and Tarik A. Rashid in 2021. LPB proved its ability to deal with complex optimization problems compared to the dragonfly algorithm (DA), genetic algorithm (GA), and particle swarm optimization (PSO). This paper presents and explains the implementation of the LPB algorithm, and it applies it as a model in a case study to maximize a fitness function. As a result, the LPB algorithm is successfully improved the initial population and achieved the optimal solution.
Emotion recognition in patients with low-grade glioma before and after surgery
Authors: Buunk A. M. , Gerritsen M. , Jeltema J. R. , Wagemakers M. , Metzemaekers J. D.M. , Groen R. J.M. , Spikman J. M.
Published: May 2022

Purpose. Research on patients with low-grade gliomas (LGG) showed neurocognitive impairments in various domains. However, social cognition has barely been investigated, while it is acknowledged as an important neurocognitive domain. Facial emotion recognition is a vital aspect of social cognition, but whether emotion recognition is affected by LGG and/or resection, is unclear. Therefore, the aim was to investigate the effect of LGG and resection, by examining emotion recognition pre- and postoperatively. Additionally, the relationship between emotion recognition and general cognition and tumor location was investigated. Methods. A longitudinal study, in which 30 patients with LGG who underwent resective surgery were included and matched with 63 healthy control participants (HC). Emotion recognition was measured with the Facial Expressions of Emotion-Stimuli and Tests (FEEST). General cognition was measured with neuropsychological tests. Correlations, within-group and between-group comparisons were calculated. Results. Before surgery, patients performed significantly worse than HC on FEEST total (M=46.9, SD=5.4 vs. M=49.5, SD=4.9, p<0.05, d=0.52) and FEEST Anger (M=7.6, SD=1.9 vs. M=8.3, SD=1.5, p<0.05, d=0.43). Paired comparisons showed no significant differences between FEEST-scores before and post-surgery. No significant correlations with general cognition (memory) and tumor location were found. Conclusion. This study shows similar impairments in emotion recognition in patients with LGG before and after resection, which indicates that the tumor itself contributes significantly to social cognitive dysfunction and that surgery caused no additional deficit. Impairments were not related to general cognitive deficits or tumor location. Consequently, incorporating tests for emotion recognition into neuropsychological assessment of patients with LGG is important.
Effects of ACTH Treatment in Infantile Spasm; Insights from Electrocardiography and Echocardiography
Authors: Cevik berna saylan , ünver olcay , doğancı demet deniz , sağer güneş , akalın figen , türkdoğan dilşad
Published: May 2022

Objective: Infantile spasms (ISs) are a group of epileptic disorders, which represents the most frequent type of epilepsy in the first year of life. The most effective treatment for IS is adrenocorticotropic hormone (ACTH). We hypothesized that ACTH treatment might have cardiac adverse effects. This study aimed to evaluate the effects of ACTH treatment on the heart muscle and/or arrhythmia risk in patients with IS.Methods: Twenty-four patients with IS and 24 healthy children (control group) participated in the study. Electroencephalography (EEG), electrocardiography (ECG), and transthoracic echocardiography were studied during treatment, and evaluations were made at 0-2-4 and 6th months of the treatment. Results: None of the patients had significant tachycardia or bradycardia when compared with the healthy group, or during treatment. On the other hand, values of the PR, QRS, QT, tp/te, tpte/QT, and tpte/QTc values were significantly increased compared with either pretreatment values or each other, which indicated an increased arrhythmia risk in the patient group. In transthoracic echocardiographic examinations, we observed diminished diastolic dysfunctions, either with pulse wave or TDI Doppler. We found a significant difference between the groups in terms of longitudinal strain parameters. Conclusion: Although we use low-dose and short-duration ACTH treatment in patients with IS, it may cause subclinical damage to the heart muscle and an increased risk of arrhythmia.
Measurement-device-independent Quantum Key Agreement against Collective Noisy Channel
Authors: Zhou Yi-Hua , Xu Yang , Yang Yu-Guang , Shi Wei-Min , Chen Ze-Song
Published: May 2022

Quantum key agreement (QKA) permits participants to constitute a shared key on a quantum channel, while no participants can independently determine the shared key. However, existing Measurement-device-independent (MDI) protocols cannot resist channel noise, and noise-resistant QKA protocols cannot resist side-channel attacks caused by equipment defects. In this paper, we design a MDI-QKA protocol against collective-dephasing noise based on GHZ states. First, in our protocol, Alice and Bob prepare a certain number of GHZ states respectively, and then send two particles of each GHZ state to Charlie for bell measurement. Results are that Alice and Bob can obtain Bell states through entanglement exchange with the help of dishonest Charlie. Meanwhile ensures the transmission process noise-resisted. Then, Alice and Bob encode their key components to the particle in their hands and construct logical quantum states against collective noise through additional particles and CNOT operation to implement MDI-QKA. Compared with existing MDI-QKA protocols, our protocol uses logical quantum states during particle transfers, which makes the protocol immune to collective‑dephasing noise, and therefore improving the final key rate. Security analysis shows that our protocol can resist common insider and outsider attacks.
Preliminary structural proteome of the monkeypox virus causing a multi-country outbreak in May 2022
Authors: Parigger Lena , Krassnigg Andreas , Grabuschnig Stefan , Resch Verena , Gruber Karl , Steinkellner Georg , Gruber Christian C.
Published: May 2022

The monkeypox virus (MPX) belongs to the orthopoxvirus genus of the Poxviridae family, is endemic in parts of Africa, and causes a disease in humans similar to smallpox. The most recent outbreak of MPX in 2022 is already affecting 19 countries on different continents and has consequently become a focus of interest. In particular, a molecular understanding of the virus is essential to study infection processes and pathogen-host interactions, predict tropism changes, or guide drug development and discovery as well as vaccine development or adaptation at a very early stage. Herein we present a study of the structural genome of the currently emerging MPX virus: our analysis revealed 10,043 characteristic candidate open reading frames (ORFs), and a subsequent BLAST search of the non-redundant protein database and PDB reduced the number of suspected ORFs to 925 and 123 protein sequences, respectively. Finally, we provide the 3D structures of these 123 protein sequences, which were predicted by homology modeling and are available for download.
In-Vitro results of EG-Covimab-H (Lab cultivated Human polyclonal antibodies) for neutralizing SARS-CoV-2 Virus & safety on tissues.
Authors: Mohammed Alaa Abdelkarim , C Prof. Datuk Sri Mike
Published: May 2022

AbstractThe debate between the active immunisation versus the passive immunisation has been the subject of discussion since the start of SARS-CoV-2 pandemic. the second debate was monoclonal antibodies versus the polyclonal antibodies in the passive vaccination, which one is more potent and more safe for the patients. Which one is valuable for the industry and the patient in the same time. While this is not the subject of this research, but this research adopted the polyclonal antibodies with new technique in production to cope with the industry needs and at the same time to achieve the best results for the patients. EG-Covimab-H, is a polyclonal antibodies derived from cultivating Switched memory B-Lymphocytes from convalescent patient (2-6 after testing negative and recovering from moderate to sever infection). The isolated B Lymphocytes are cultivated in special media and Antibodies were harvested and used in this research. The research focus in testing the tissue toxicity and ability of EG-Covimab-H in neutralizing the SARS-CoV-2 Virus that infected the tissue culture.Tissue culture was done on VERO-6 Cells. EG-Covimab-H was tested for 120 hours on different dilutions (1/2,1/4,1/8,1/16,1/32,1/64, up to 1/2056). The result of the toxicity test showed 90-100% safety in the dilution of 1/8 and 1/16 respectively. Therefore, the efficacy test was done with the safe dilution and in the same dilution algorithm. The result came as effectiveness is 95%-965 success in neutralizing the virus within 96 hours.The neutralization curve did not show any surge in the number of virus copies after applying the polyclonal antibodies and the decline in the number started to show within 48 hours.
The functions of safety in psychotherapy: A comparative analysis across therapeutic schools
Authors: Podolan Martin
Published: May 2022

There is a certain consensus in the psychotherapeutic literature that safety plays a central role in human development and psychotherapy and that lack of safety undermines mental health. Nevertheless, the role of safety in psychotherapy has not yet been systematically examined. Therefore, we analyzed and compared the concept of safety across some main psychotherapeutic schools (psychodynamic, cognitive-behavioral, humanistic). Our goal was to identify and integrate the different functions of safety in psychotherapy on a transtheoretical basis. Our analysis showed that safety is rightly prioritized across psychotherapy schools mainly because a lack of safety activates psychobiological defense systems. Our findings suggest that the main role of safety is to secure survival, facilitate restoration, promote exploration, sustain risk-taking, and enable integration, with these functions being complementary and dependent on the context. It appears that the effective functioning of human development and psychotherapy does not require the continuous maintenance of the maximum possible safety, but enough safety. Although safety provides the necessary basis for an adequate ontogenetic development as well as for treatment progress, safety’s misdosage (e.g., lack, excess), misconstruction (e.g., misattunement, misinterpretation), or misuse (exploitation, idealization) may hinder the healthy development of attachment, identity, autonomy, self/co-regulation as well as the ability to tolerate and cope with dangers, risks, insecurities, or frustrations, with negative consequences on the therapeutic process. Future research is suggested to further explore the role of safety in psychotherapy.
The Importance of Gravity Vector on Adult Mammalian Organisms: Effects of Hyper-Gravity on Mouse Testis
Authors: Bonetto Valentina , Magnelli Valeria , Sabbatini Maurizio , Caprì Flavia , Tavella Sara , Masini Maria Angela
Published: May 2022

In the time of space explorations, the effect of hyper-gravity on the human physiology is a topic relatively neglected. Nevertheless, astronauts have several experiences of hyper-gravity during their mission. The main disturbance of altered gravity can be imputed to cell cytoskeleton alteration and physiologic homeostasis of the body. Testis has been revealed to be an organ particularly sensible, to be affected by environmental alteration and physiological disturbance. This makes testis an organ eligible for investigating the alteration following exposure to altered gravity. In our study, mice were exposed to hypergravity (3g for 14 days) in Large Diameter Centrifuge. We have observed morphological alteration of the regular architecture of the seminiferous tubules of testis as well as an altered expression of factors involved in junctional complexes of Sertoli cells, responsible to assure the morpho-functional integrity of the organ. The expression of key receptors in the physiological performance, such as Androgen Receptors and Interstitial Cells Stimulating Hormone (ICSH) receptors have been found lower expressed. All these findings indicate the occurrence of altered physiological performance of the organ such as the reduction of the spermatozoa number and an altered relationships with the endocrine physiology following hypergravity exposure.
Exploring Pattern Recognition: What is the relationship between the recognition of words, faces and other objects?
Authors: Maratos Frances , Chu Kar-Man , Lipka Sigrid , Stupple Edward , Parente Fabio
Published: May 2022

Debate surrounds processes of visual recognition, with no consensus as to whether recognition of distinct object categories (faces, bodies, cars, and words) is domain specific or subserved by domain-general visual recognition mechanisms. Here, we investigated correlations between the performance of 74 participants on recognition tasks for words, faces and other object categories. Participants completed a counter-balanced test battery of the Cambridge Face, Car and Body Parts Memory tests, as well as a standard lexical decision task with response time (RT) and accuracy as dependent variables. We found that response times were consistently positively and significantly correlated between most object categories; for example, face recognition with body and car recognition, but also with word and non-word recognition. However, correlations between accuracy scores were more limited; for example, face recognition did not correlate with non-word recognition. Additionally, controlling for dyslexia resulted in some correlations becoming more robust (e.g., regular- and irregular-word recognition accuracy) or emerging (e.g., RT between body and real-word recognition), whilst others were partialled out (e.g., recognition accuracy between irregular words and confusable non-words). These results suggest some degree of functional overlap in the neural mechanisms subserving recognition of these different object categories, generally supporting a domain-general view of pattern recognition. This stated, observed relationships were complex. In order to further our understanding of pattern recognition, research investigating the recognition of words, faces and other objects in dyslexic individuals is recommended, as is research examining developmental trajectories of pattern recognition and research exploiting neuroimaging methodologies.
Mediating role of perceived service quality between behavioral characteristics, security risk and internet banking usage
Authors: O. Ighomereho Salome , S. Sajuyigbe Ademola
Published: May 2022

Internet banking is an essential component of banking. However, most bank customers in Nigeria do not make optimal use of the service. The paper investigates the influence of behavioral characteristics, security risk and perceived service quality on internet banking usage. A research model was developed by incorporating security risk to the antecedent variables of the Theory of Planned Behavior with perceived service quality serving as a mediator. A questionnaire was utilized to gather information from 333 bank customers who had signed up for internet banking. According to the results of structural equation modeling, internet banking usage is positively correlated with subjective norm, perceived behavioral control, and perceived service quality. Security risk, on the other hand, has a negative correlation. The use of internet banking is unaffected by one’s attitude. Regarding the relationship with perceived service quality, attitude and subjective norm were insignificant, while perceived behavioral control and security risk were significant. The mediating effect indicates that perceived service quality did not mediate the association between attitude and internet banking usage. However, subjective norm, perceived behavioral control and security risk partially mediate the relationship. Thus, aside from attitude, the study confirms the Theory of Planned Behavior. The findings provide essential insights into internet banking usage behavior, which is relevant to bank managers and industry regulators.
Percepções da Disciplina de Sociologia Entre Alunos do 3° Ano do Ensino Médio
Authors: Sousa Luciano de Melo , Nascimento Edvaldo Gonçalves do
Published: May 2022

Este artigo faz uma análise discursiva da percepção da disciplina Sociologia entre alunos do 3° ano do Ensino Médio de uma escola pública do Piaui. Partiu-se do pressuposto teórico de que a Sociologia deve problematizar a vida do aluno, sua existência no mundo real, com suas implicações nos diversos campos da vida. Fruto de pesquisa de conclusão de curso, seu problema foi: qual a percepção que os estudantes do 3° ano do Ensino Médio da Unidade Escolar Barão de Gurgueia têm sobre a disciplina Sociologia? Para analisar aspectos envolvidos nesta problemática, a metodologia utilizada constou de uma abordagem que envolveu a pesquisa qualitativa, com entrevistas feitas entre os estudantes, e como método de interpretação a análise de conteúdo. Os resultados achados no campo de pesquisa revelaram que alguns alunos têm uma certa compreensão sobre o que seja o objeto da Sociologia na escola enquanto outros não o compreendem. Do mesmo modo, uma parte deles acredita que a disciplina dialoga com a vida cotidiana dos mesmos, mas, diferentemente, outra parte não identifica essa interação entre a Sociologia e suas experiências sociais. Desse modo, a contextualização curricular ainda se configura como um desafio fundamental no ensino da Sociologia.
Por um Novo Mundo Que há de Vir e Vida Da Pedra
Authors: Pereira de Carvalho Paulo Dourian , Moreira Claudia
Published: May 2022

Essa submissão originalmente se tratava apenas da prosa poética "Por um Novo Mundo Que há de Vir" do senhor Paulo Dorian Pereira de Carvalho, porém, uma vez se tratando do tópico "Prosa Poética", a mesma será publicada juntamente com o texto "Vida Da Pedra" da autora Cláudia Moreira.
Interrogação Científica Para a Contemporaneidade: Entrevista com Maria da Conceição de Almeida e Alexsandro Galeno de Araujo
Authors: França Fagner Torres de
Published: May 2022

Em um diálogo para a revista CRONOS, a antropóloga Maria da Conceição de Almeida, professora doutora titular do Departamento de Fundamentos e Políticas da Educação da UFRN, também ligada ao Programa de Pós-Graduação em Ciências Sociais, e o professor doutor Alexsandro Galeno de Araújo Dantas, do Departamento de Graduação e do Programa de Pós-Graduação em Ciências Sociais da UFRN discutem sobre os desafios da ciência, do intelectual e da universidade para enfrentar as questões colocadas pela sociedade contemporânea.
Ética Complexa, Ciência e Sujeito Bifurcações na Interface Homem-Máquina
Authors: Lima de Medeiros Andrezza , Rita Pereira Xavier Maria , Pimentel Lopes Júnior Orivaldo
Published: May 2022

Busca-se no presente artigo compreender o caráter ambivalente da ciência. Partimos do pressuposto de que existe uma complexidade intrínseca no cerne da ciência, a qual perpassa seus fundamentos éticos. Essa ambivalência torna-se mais evidente quando o homem passa a intensificar o uso de dispositivos no contexto da sociedade global contemporânea. Tal conjuntura origina bifurcações no modo de interação do humano com o não humano. Palavras-chave: Ética. Ciência. Bifurcações. Dispositivo. Contemporâneo.
Diferentes Teorias da Midiatização e Sua Aplicação ao Futebol Brasileiro
Authors: Christofoletti Danilo Fontanetti
Published: May 2022

Esse artigo tem o objetivo de propor uma discussão acerca do processo de midiatização na sociedade brasileira, em específico, a midiatização do futebol brasileiro, considerando a perspectiva de midiatização proposta por Stig Hjarvard (2014), em sua obra: “A midiatização da cultura e sociedade”. Sob essa perspectiva, a mídia tornou-se tão intimamente ligada às demais instituições sociais que ela mesma se tornou uma instituição social, semi-independente, que constantemente interage e modifica os demais campos sociais. Desta maneira, já não é mais possível pensar a mídia separada do resto da cultura e sociedade, da mesma forma em que não se pode mais pensar as diversas esferas sociais operando fora da lógica midiática. O futebol brasileiro, símbolo da maior expressão esportiva nacional, também passa a operar sob a lógica midiática, se tornando, então, um esporte midiatizado, o que influencia em todos os aspectos de seu funcionamento e forma de existir.
De Collor a Temer
Authors: Silva Flávio José Rocha da
Published: May 2022

Este artigo tem como objetivo fazer um breve resgate histórico do processo de privatização da água no Brasil promovida pelos governantes Fernando Collor de Mello (1990-1992), Fernando Henrique Cardoso (1995-2003), Luiz Inácio Lula da Silva (2003-2011), Dilma Rousseff (2011-2016) e Michel Temer (2016). Embasamos nosso trabalho em pesquisa bibliográfica sobre o tema referido e análise de algumas leis que foram elaboradas e promulgadas pelos referidos governos que de alguma forma facilitaram o processo de abertura de capital de empresas públicas de saneamento estaduais e municipais e/ou a concessão de algumas destas nas chamadas Parcerias Público-Privada – PPPs. Embora a privatização da água não seja algo recente no cotidiano dos brasileiros e tenha acontecido com diversas roupagens em diferentes regiões do país ao longo da nossa história, este fato tomou consistência como política governamental desde o governo do presidente Fernando Collor de Mello, quando inicia-se a Era Neoliberal no Brasil.
Ciência da Política
Authors: Diego Santos Avelino Pablo
Published: May 2022

Resenha acadêmica da obra a A ciência da política - uma introdução
As Jornadas de Junho de 2013 e a Atualidade do Marxismo
Authors: Araújo Valença Daniel
Published: May 2022

Os atos de junho sacudiram o país e provocaram inúmeras análises. As situadas no campo liberal, conservador e pós-moderno se tocaram ao apontar o fim das formas organizativas e mobilizadoras do século XX. De outro lado, a partir de referenciais críticos, foram levantadas questões atinentes ao direito à cidade, à precarização do proletariado, entre outras. Ambas as perspectivas, todavia, pecam por tratar as Jornadas de Junho como continuidade, desconsiderando as rupturas ocorridas durante o processo. São elas que possibilitam, no entanto, apreender o porquê dos atos bem como da ressignificação destes. Entre os dias treze e vinte de junho de 2013, houve uma intensa luta pelo sentido dos atos, compreensível quando recorremos às categorias “ideologia” e “hegemonia”. Estas, o marxismo e a organização política, ao contrário do aventado, permanecem atuais e necessárias para a compreensão e a condução da luta política.
Movimentos Sociais, Arenas Decisórias e Dinâmicas na Elaboração do Programa Territórios da Cidadania
Authors: Medeiros de Nascimento Shesby André , Alves da Silva Jenair , Vaz de Moura Joana Tereza
Published: May 2022

Esse artigo tem como objetivo tratar das relações estabelecidas pelos diversos atores políticos e sociais na construção do Programa Territórios da Cidadania- PTC, criado em 2008, baseado na ideia da gestão territorial e intersetorial. Com efeito, buscamos compreender práticas, discursos e redes mobilizados que resultaram em suas implicações no sistema político. Para tanto, identificamos alguns atores centrais no processo de construção da política pública a partir de um mapeamento sobre o Programa através de documentos e relatórios do Ministério de Desenvolvimento Agrário, especificamente da Secretaria de Desenvolvimento Territorial. Os documentos foram necessários para apontar as principais arenas decisórias que foram envolvidas nesse processo. A partir desse primeiro mapeamento, trabalhamos com entrevistas em profundidade com as pessoas que estavam envolvidas no processo de elaboração dessa política, buscando qualificar a discussão sobre os modos de participação e de envolvimento na construção da política. Buscamos, portanto, compreender as relações político-institucionais entre Estado e movimentos sociais no âmbito dos espaços de discussão que antecederam a criação do Programa. Percebemos que a ocupação de cargos é uma tática adotada por alguns movimentos sociais de modo a criar novas estratégias e estabelecer articulações possíveis com aqueles que estão dentro do Estado.
Análisis de la especialización de la caña de azúcar en México, 1980-2017
Authors: Bustamante Lara Tzatzil Isela , Alvarado Silva Adrián
Published: May 2022

El objetivo de este artículo es analizar las ventajas y la especialización en la producción de caña de azúcar en México como fuentes de generación de competitividad de 1980 a 2017, con la finalidad de identificar el nivel de competitividad de los estados productores, con objeto de determinar si se tiene una relación directa con la especialización. Para el cumplimiento del objetivo se desarrolló el cálculo y el análisis de tres indicadores regionales: el cociente de localización, el coeficiente de especialización y el de redistribución. La industria azucarera repercute en diversos aspectos, lo que deja ver una limitante para la investigación a causa de que la accesibilidad de la información es limitada. Como principal resultado, se prueba que hay diferencias en la especialización entre los principales estados productores de caña de azúcar originadas por las disparidades de sus ventajas. Se concluye que existen variaciones en los resultados del cociente de localización relacionadas principalmente con la fluctuación del precio de la azúcar.
Resistencias y sincretismo indígena de mujeres tének y nahuas de San Luis Potosí, México, en la experiencia del autocuidado durante el embarazo y parto
Authors: Rangel Flores Yesica Yolanda , López Pérez Oresta , Juárez Moreno Mariana
Published: May 2022

El objetivo de este artículo es documentar las experiencias de mujeres tének y nahuas en el autocuidado durante el embarazo y el parto y sus percepciones sobre la atención institucionalizada. Se emplearon metodologías mixtas. Los datos se recolectaron mediante encuestas y entrevistas grupales. Se observó que las mujeres implementan estrategias de resistencia para continuar el acompañamiento de las parteras, y aunque se incorporan al seguimiento de los servicios de salud, conciben la participación sanitaria más como un medio de control que como una garantía del derecho a la salud. Este artículo aporta elementos para la reflexión y el análisis de la salud materna en contextos indígenas. El valor de este radica en que analiza las resistencias al servicio de salud institucional develando los vacíos, omisiones y violencia en la práctica médica. Se concluye que la consejería familiar resulta relevante para decidir sobre sus embarazos y partos, frente a servicios de salud que asumen una mirada etnocéntrica que minimiza y desautoriza sus saberes y terapéuticas.