bluuebunny/crossref_metadata_2025 huggingface dataset:
Navigating Care: Understanding Cancer Patients’ Experiences with Systemic Radionuclide Therapy
Authors: Starkbaum Johannes , Thircuir Solenn , Winkler Florian , Griessler Erich
Published: December 2024

Systemic Radionuclide Therapy (SRT), using the radioactive substance Lutathera (177LU), has emerged as a promising treatment option for neuroendocrine tumors (NETs). While studies suggest that SRT has rather positive health outcomes, there is a lack of research exploring patients’ experiences of this treatment. This may be because NETs are widely regarded as a rare disease and SRT as an emerging technology. This paper explores the journeys NET patients take to receive SRT and their perceptions of its clinical application. Our findings highlight the specific challenges that patients face with SRT and how some of these are mitigated in clinical practice. These include the often long journeys to specific treatment options, and how these may be subject to social inequalities. In the specific context of the clinic, we documented the challenges posed by the radiation involved, particularly the need for social isolation. We find that notions of care from the patient's perspective are relevant to increasing well-being and trust in medicine. Our study thus highlights the importance of care in a specific case of an emerging technology in cancer research, which typically receives much less attention than issues of innovation and risk management.
LLM-based program analysis for source codes, abstract syntax trees and WebAssembly instructions
Authors: Deng Liangjun , Zhong Qi , Qiu Yao , Chen Jingxue , Lei Hang , Yang Shunkun , Zhou Liming , Cheng Hongyuan
Published: December 2024

The advancement of Web3.0 technology has brought about an urgent need for ensuring the safety and reliability of the software systems. Program analysis, a crucial aspect of software security research needs a unified solution for various cross-language program. Moreover, the previous studies regard the necessity of capturing structured features from the ASTs, commonly holding a conception that plain text and compiled binary instructions were challenging to represent and identify. This paper proposes a method of program instruction file embedding directly into natural language. we train large language models (LLMs) with 20 billion to identify defect and non-defect of WebAssembly. Experiment results demonstrate that program instruction analysis surpasses traditional techniques, achieving state-of-the-art accuracy exceeding 98.1 percent. Our study also suggests a practical approach of plain text embedding using a 7.65 billion parameters language model. Interestingly, misformatted source cdoes are readable to humans but un-compilable, and the accuracy remains above 98.63 percent. This paper not only introduces novel instruction and plain text embedding approach for future program security analysis, but also provides new insights for subsequent research about the three program analysis forms of plain text, ASTs, and instructions.
Sero-Prevalence of Syphilis Infection Among Pregnant Women Attending Banadir Hospital, Mogadishu-Somalia
Authors: AHMED ABDULRAZAK MOHAMED , Fujeyra Abdalle
Published: December 2024

This research explores the impact of health factors on the prevalence of syphilis among pregnant women receiving care at Banadir Hospital in Mogadishu, Somalia. A sample size of 150 individuals was studied, revealing that the majority were young (aged 21–30) and married, and had high levels of education and income. A syphilis prevalence rate of 0.7% was recorded, and many participants lacked awareness concerning transmitted diseases (STDs). Limited levels of education (64.7) and income (54) were identified as potential barriers to healthcare access, resulting in increased susceptibility to infections. The records show that there are pregnancies and late-stage pregnancies, with a greater chance of infection due to limited involvement in healthcare services due to the individual's past experiences of motherhood and pregnancy complications. Despite being uncommonly seen the results emphasize the challenges in understanding sexually transmitted diseases (STDs) due to economic and educational limitations which affect awareness and access to medical care enhancing screening for syphilis during pregnancy promoting public awareness programs on healthcare issues and offering specific interventions along with socioeconomic help could enhance the health outcomes of mothers and decrease the risk of disease transmission.
Histological comparison of formocresol, enamel matrix derivative and turmeric extract as pulpotomy agents in primary teeth
Authors: Bashir Nazia , Naz Shazia , Dastgeer Rabia , Khatoon Samina , Hussain Md. Asdaq
Published: December 2024

Background
This study aimed to compare and histologically evaluate the pulpal inflammatory response and dentin bridge formation using Formocresol (FC), Enamel Matrix Derivative (EMD), and Turmeric Extract (TE) as pulpotomy agents in primary teeth.
Methods
Eighty-one patients, aged 8–10 years, requiring both serial extraction and pulpotomy of primary molars were enrolled in this study. One symptomless carious molar tooth from each patient was selected. The participants were divided into three equal groups (n = 27 each) based on the time planned for serial extraction: 1 week, 2 weeks, and 6 months. Each group was subdivided into three sub-groups (n = 9) according to the pulpotomy agent used (FC, EMD, or TE). Histological evaluations were performed post-extraction to assess pulpal inflammatory response and dentin bridge formation. Statistical analysis was carried out using Fisher’s exact test, with a significance threshold set at p < 0.05.
Results
A statistically significant difference was observed among the three materials regarding pulpal inflammatory response and dentin bridge formation. At 1 week, the FC and EMD groups had moderate inflammation in 88.9% and 77.8% of cases, respectively, while the TE group showed mild inflammation in 55.6% of cases. After 2 weeks, 77.8% of the TE group displayed mild inflammation, 66.7% of the EMD group showed moderate inflammation, and 22.2% of the FC group exhibited severe inflammatory response. By 6 months, 88.9% of the TE group had mild inflammation, while 44.4% of the EMD group showed moderate and 33.3% of the FC group demonstrated severe inflammation. Regarding dentin bridge formation after 6 months, 77.8% of the EMD group exhibited over 75% bridge formation whereas 88.9% of the FC group showed no bridge formation. The TE group showed moderate development with 66.7% showing less than 25% bridge formation.
Conclusion
TE and EMD demonstrated promising results in this study. Compared to FC, TE showed potential in reducing pulpal inflammation, while EMD was the most effective at promoting dentin bridge formation. However, further studies with extended follow-up are needed to determine the safe clinical indications for these alternative pulpotomy agents in primary teeth.
Effects of geographical and soil factors on soil arsenic levels in a typical arsenic-contaminated paddy field area
Authors: Zhang Renjie , Jiang Liheng , Dong Tianhao , Xie Yunhe , Pan Shufang , Liu Saihua , Huang Rui , Ji Xionghui , Xue Tao
Published: December 2024

Heavy metal pollution in agricultural land has emerged as a contemporary environmental issue of prominent concern. The concentration of heavy metals in soil is influenced not only by inherent soil properties but also by geographical factors. Moreover, the identification of its influencing factors is challenging because of the intricate interactive effects among them. Previous studies primarily focused on single-factor identification and spatial distribution characterization, neglecting the characteristics and spatial features of soil heavy metal concentration under the interactive effects of geographical factors and soil properties. This study assessed the influence of geographical factors, soil properties, and their interactive effects on the spatial distribution of soil arsenic (As), in a typical arsenic-contaminated paddy field area by employing machine learning, analysis of variance, and spatial analysis methods. The findings show that the primary factors influencing the distribution of soil As are elevation, roads, rivers, soil pH, and cation exchange capacity (CEC). Moreover, the interactive effect between elevation and soil CEC had a significant effect on soil As, exhibiting non-linear and spatially homogeneous characteristics. The interactive effect between rivers and both soil pH and soil CEC exhibited non-linear and spatially heterogeneous effects on soil As. Additionally, the interactive effect between roads and soil pH affected soil As, with non-linear and spatially homogeneous characteristics. By identifying the main influencing factors of As in paddy soil, this study further explores the variation characteristics of soil As concentration under the interactive effects of geographical factors and soil properties. These insights can serve as a valuable reference for the precise prevention of As pollution in paddy field area.
Biomarkers related to interferon-γ pathway in myocardial ischemia-reperfusion injury and the potential molecular mechanisms
Authors: Jia Fang , Jiang Wei , Zhang Yan , Zhang Lisha , Han Tuo , Liu Danmeng , Xue Jiahong , Deng Fuxue
Published: December 2024

Background
Although reperfusion therapy can reduce the mortality of myocardial infarction, it results in myocardial ischemia-reperfusion injury (MIRI). The molecular mechanism by which the interferon-γ pathway affects MIRI is unclear, so we addressed this problem by mining transcriptome and single-cell sequencing data.
Methods
The GSE160516 and GSE83472 datasets, single cell RNA sequencing (scRNA-seq) data of GSE227088 dataset and 182 interferon-γ pathway related genes (IRGs) were retrieved and incorporated into this study. The differentially expressed genes (DEGs) between MIRI and control samples were searched, the candidate genes were obtained by intersecting DEGs with IRGs. The protein-protein interaction (PPI) analysis was utilized for selecting key genes from candidate genes. Moreover, key genes with significant expression and consistent trend in GSE160516 and GSE83472 datasets were selected as biomarkers. The biological functions and regulatory mechanism of biomarkers were investigated by enrichment analysis and predicting the upstream molecules targeting them. Ulteriorly, cell clusters were identified via unsupervised cluster analysis and merged into different cell types by cell annotation. Cell types in which biomarkers observably and differentially expressed were selected as crucial cell types. Finally, cell communication and pseudo-time analysis were implemented based on crucial cell types.
Results
Totally 34 candidate genes were searched by overlapping 1,930 DEGs with 182 IRGs. Nine key genes were singled out from candidate genes, of which Myd88 and Trp53 were significantly upregulated in the MIRI samples of GSE160516 and GSE83472 datasets, so they were identified as biomarkers. Besides, they participated in pathways such as ribosome, spliceosome and cell cycle. Myd88 might be simultaneously regulated by mmu-miR-361-3p and mmu-miR-421-3p, and Trp53 could be regulated by Abl1 and Tead2. Totally 25 cell clusters were merged into six cell types, of which three crucial cell types (cardiomyocyte, fibroblast and macrophage) could interact with each other through receptor-ligand. Pseudo-time analysis revealed states 1, 2 and 5 of macrophages might be associated with MIRI.
Conclusion
Two biomarkers (Myd88 and Trp53) related to IRGs in MIRI were mined, providing a reference for elucidating the mechanism of interferon-γ pathway on MIRI.
Optimizing Internal Logistics in Manufacturing Facilities: Analyzing Alternative Transportation Routes for Cost-Effective and Flexible Solutions
Authors: Coşkun Şengül
Published: December 2024

This study aims to optimize internal logistics processes in manufacturing facilities by analyzing alternative transportation routes and providing optimal solutions. Challenges such as increasing product diversity, complex supply chains, and uncertain demand structures have made the management of logistics processes increasingly critical. By employing vehicle routing methods like Dijkstra’s and k-shortest path algorithms, the study determines optimal transportation routes between facility locations, considering competitive priorities such as cost, quality, delivery speed, and flexibility. In this research, data related to internal logistics processes were analyzed, and a distance matrix was created using the savings algorithm. Based on this matrix, optimal routes were calculated using the k-shortest path algorithm. As part of the application, suitable routes were identified for materials that need to be transported between storage depots, production, and assembly areas within a manufacturing facility. The developed method minimized transportation costs and enhanced flexibility in internal transportation processes. The results demonstrated the effectiveness of collaborative transportation strategies and validated the applicability of the proposed approach through alternative scenario analyses. The study presents a model that serves as a guide not only for the current facility but also for different industries with similar internal logistics processes. It is anticipated that the research will make significant contributions to customer-focused, cost-effective, and flexible logistics management strategies for businesses.
Wie wäre es kritisch zu sein?
Authors: Gröschner Max , Krückel Florian , Neubauer Manuel
Published: December 2024

Future Skills rücken ein ökonomisches Verständnis von Kritik als Problemlösung in den Fokus. In Kontrastierung zu einem an Kompetenzen und Skills orientierten Kritikbegriff wird in diesem Artikel Kritik als Haltung im Anschluss an Foucault diskutiert. Anschliessend an den vorgestellten Kritikbegriff werden drei Strukturelemente einer kritischen Haltung herausgearbeitet, die exemplarisch für die Analyse der Bewegung #IchBinHanna genutzt werden. Der Artikel verfolgt das Ziel, den Modus einer Kritik als Haltung in einer Kultur der Digitalität nachzuzeichnen, um damit auf die Bedeutung einer Kritik jenseits von Future Skills zu verweisen.
ПРОБЛЕМА ГЛОБАЛЬНОГО НЕРАВЕНСТВА В ТЕОРИЯХ РЕВОЛЮЦИЙ (КРАТКИЙ ЭКСКУРС)
Authors: Демиденко С.В. , Маргулис С.Б.
Published: December 2024

Статья посвящена анализу подходов к исследованию фактора неравенства в революционных теориях конца XIX – начала XXI вв. С крушением Советского Союза и утратой марксистской парадигмой статуса единственно верной в отечественной науке развернулась дискуссия относительно предпосылок и причин возникновения социальных волнений и революционных взрывов. Неравенству, при этом, не уделялось должного внимания. Вопрос рассматривался либо в разрезе экономических проблем, либо с точки зрения социальных диспропорций. Феномен неравенства имеет весьма сложную природу, соответственно, велика и его роль с точки зрения воздействия на возникновение явлений деструктивных, приводящих к демонтажу текущего социально-политического порядка. В этой связи важным представляется сделать срез научных подходов, чтобы опередить уровень изученности темы и выявить направления для дальнейших исследований.

The article is devoted to the analysis of approaches to the study of the inequality factor in the revolutionary theories of the late XIX – early XXI c. With the collapse of the USSR and loss of the status of the only true Marxist paradigm in Russian science, a discussion unfolded regarding the prerequisites and causes of social unrest and revolutionary explosions, at the same time, in Western science it did not stop for a day. Inequality, as practice shows, was not given due attention. The issue was considered either in the context of economic problems or from the point of view of social imbalances. The phenomenon of inequality has a very complex nature, accordingly, its role is also great in terms of influencing the emergence of destructive phenomena leading to the dismantling of the current socio-political order. In this regard, it is important to make a cross-section of scientific approaches in order to get ahead of the level of knowledge of the topic and identify areas for further research.
Российские ученые-эмигранты и Карлов университет: пути и модели интеграции (1920–1930-е гг.)
Authors: Ковалев М.В.
Published: December 2024

Статья посвящена анализу путей и моделей взаимодействия русских ученых-эмигрантов с Карловым университетом в 1920–1930-е гг. На основе архивных документов и на конкретных примерах были установлены обстоятельства приглашения эмигрантов на преподавательские должности, обрисованы условия их научно-педагогической работы. Было выявлено, что проблемы трудоустройства зачастую были связаны не с боязнью конкуренции со стороны местных ученых, но были вызваны ограниченностью штатного расписания и бюджета, отсутствием у русских эмигрантов чехословацкого гражданства. Кроме того, в Карловом университете отсутствовала потребность в большом количестве иностранных специалистов, тем более в тех областях, где могли успешно работать местные кадры. Сделан вывод, что чехословацкая образовательная среда впитывала русских ученых гораздо хуже болгарской или югославской. Было продемонстрировано существование различных моделей интеграции русских ученых в Карлов университет. Важную роль в приглашении на работу и трудовом закреплении зачастую играли влиятельные гаранты и патроны из числа местных профессоров. Наибольшие шансы на профессиональную интеграцию получали те ученые, кто сумел приспособить свои научно-педагогические практики к потребностям и запросам местной среды.

In this article the ways and models of interaction between Russian émigré scientists and Charles University in the 1920s and 1930s were analysed. On the basis of archival documents, the circumstances of inviting of émigré scientists to university positions were established, and the conditions of their scientific and pedagogical work were outlined. It was found that employment problems were often not related to the fear of competition from local scientists, but were caused by the limited staffing and budget, and the lack of Czechoslovak citizenship among Russian emigrants. In addition, at Charles University there was no need for a large number of foreign specialists, especially in those areas where local scientists could work successfully. The example of the Charles university shows that the Czechoslovak educational environment absorbed Russian scientists much worse than the Bulgarian or Yugoslav ones. There were various models of integration of Russian scientists at Charles University. However, influential guarantors and patrons from among local professors often played an important role in inviting them to work and securing their employment. The greatest chances for professional integration were received by those scientists who were able to adapt their scientific and pedagogical practices to the needs and demands of the local environment.
КРЕСТЬЯНСКАЯ СЕМЬЯ КАК ПОЛЕ «БИТВЫ ПОКОЛЕНИЙ» ВО ВТОРОЙ ПОЛОВИНЕ 1920-х ГОДОВ
Authors: Вязинкин А.Ю. , Слезин А.А.
Published: December 2024

Крестьянская семья позднего нэпа рассматривается в статье как объект деятельности коммунистической молодёжи по преобразованию быта и против религии с позиций «поколенческой истории». Основное внимание уделено реакции на инновации поколения «детей революции» (их детство пришлось на послереволюционные годы) представителей крестьянского поколения «революционного перелома» (родившихся на рубеже веков). По мнению авторов, деятельность комсомола хотя и не разрушила патриархальную семью в российской деревне полностью, активно способствовала как её эволюции, так и усилению конфликта поколений. Выявлены связанные с деятельностью комсомола причины его обострения, перерастания в межпоколен-ческий разлом. Авторы рассматривают его как одну из недостаточно изученных сторон раскола деревни на антагонистические лагеря, используемого властью в це-лях ускорения социалистической модернизации.

The paper considers the peasant family of the late NEP as an object of communist youth activity aimed at life transformation and directed against religion from the standpoint of "generational history". The main attention is paid to the reaction to the innovations of the "children of the revolution" generation (their childhood fell in the post-revolutionary years), as well as representatives of the peasant generation of the "revolutionary turning point" (born at the turn of the century). According to the author, the activities of the Komsomol, although they did not completely destroy the patriarchal family in the Russian village, actively contributed both to its evolution and to the intensification of the generational conflict. The article reveals the causes of aggravation and development into the intergenerational rupture, related to the activities of the Komsomol. The author considers it as one of the insufficiently studied aspects of the village split into antagonistic camps, used by the authorities in order to accelerate socialist modernization.
«СВЯЗАННЫЕ ЦАРИ» – ВО ИМЯ ПОЛЬСКОЙ КОНСТИТУЦИИ ИЛИ РОССИЙСКОЙ ИМПЕРИИ?
Authors: Исэров А.А.
Published: December 2024

В статье разбирается сюжет, впервые упомянутый в литературе М. С. Альперовичем. 13 (2) февраля 1787 г. в Киеве польский граф Игнаций Потоцкий (1750–1809) на званом обеде сказал бывшему полковнику испанской армии, венесуэльцу Франсиско де Миранде (1750–1816), что лучшим памятником Рима показалось ему изображение царей со связанными руками (Reyes ligados pr. las manos). Эта фраза дошла до Г. А. Потёмкина, короля Станислава Августа и его окружения и получила республиканскую трактовку, которая хорошо вписывается в историю жизни собеседников: Игнаций Потоцкий станет соавтором польской Конституции 3 мая 1791 г., в 1792 г. будет исполнять обязанности военного министра, во время восстания Тадеуша Костюшко 1794 г. будет министром иностранных дел; Франсиско де Миранда с 1783 г. готовил революцию в Испанской Америке и возглавит независимую Венесуэлу в 1812 г. В статье впервые определены «связанные цари» – статуи побеждённых варварских правителей (с 1720 г. в Palazzo dei Conservatori). С середины XVI до середины XIX вв. «связанные цари» выставлялись по обе стороны от женской статуи Цереры, переделанной в образ побеждающего, триумфального Рима (Roma victrix, Roma triumphans), – композиция символизировала победу Вечного города. Выдвинута гипотеза о «двойном» смысле слов Игнация Потоцкого: и политическая декларация радикального Просвещения, и скрытый панегирик Екатерине II.

The article deals with a story first mentioned in historiography by Moisei Alperovich. On February 13 (2), 1787, the Polish Count Ignacy Potocki (1750–1809) at a dinner party in Kiev told a former colonel of the Spanish army, the Venezuelan Francisco de Miranda (1750–1816) that the best monument of Rome seemed to him the image of kings with their hands bound (Reyes ligados pr. las manos). This phrase reached Grigory Potemkin, King Stanislaus Augustus and his entourage and received a republican interpretation which fits well with the life story of the interlocutors: Ignacy Potocki would become a co-author of the Polish Constitution of May 3, 1791, in 1792 would serve as an acting War Minister, and during the Tadeusz Kosciuszko Uprising of 1794 would become the Minister of Foreign Affairs; from 1783 Francisco de Miranda was preparing a revolution in Spanish America, and in 1812 he would lead independent Venezuela. The article for the first time attributes the “kings bound” as statues of defeated barbarian rulers (from 1720 in the Palazzo dei Conservatori). From the mid-sixteenth to the mid-nineteenth centuries these “kings bound” were exhibited on both sides of the female statue of Ceres remade as an image of victorious, triumphant Rome (Roma victrix, Roma triumphans) symbolizing the victory of the Eternal City. My hypothesis is that Ignacy Potocki implied a “double” meaning: both a political declaration of the radical Enlightenment and a hidden panegyric to Catherine II.
ТЕКСТЫ И СМЫСЛЫ ПЕРВОЙ МИРОВОЙ
Authors: Ландина Л.В.
Published: December 2024

В статье рецензируется книга И. Р. Чикаловой «[Не]забытая война: Первая мировая война в документах, публицистике, воспоминаниях и исследованиях современников (1914–1941)», 2-е изд., доп. и перераб. (Минск: Беларуская навука, 2024. 507 с.)[1] как методологически новаторское комплексное исследование Великой войны в жанре интеллектуальной истории. Автор раскрывает ход и различные аспекты Первой мировой войны, опираясь на опубликованные на протяжении 1914–1941 гг. источники, созданные ее участниками и современниками. В книге рассматривается также историографическая рефлексия Первой мировой войны в научных исследованиях межвоенного времени. Книга осмысливается как многоуровневый нарратив, представляющий совокупность и систему текстов – собственно авторского, текстов источников и научных работ, созданных на протяжении 1914–1941 гг., а также гипертекста самой книги в единстве ее иллюстративной и текстовой составляющей. Представленная книга выступает примером гибридного жанра, соединяя в себе исторический нарратив, источниковедческое исследование и историографическую рефлексию, являясь одновременно ярким примером работы в парадигме интеллектуальной истории. Автор создает собственную конструкцию исторической памяти о Первой мировой войне, что весьма востребовано в актуальных социокультурных и политических реалиях.

The article reviews the book of Doctor of Historical Sciences, Professor I.R. Chikalova "[Not] forgotten war: World War I in documents, journalism, memoirs and studies of contemporaries (1914-1941)," 2nd ed., Addendum and revision. (Minsk: Belarusian Navuk, 2024. 507 pp.) As a methodologically innovative comprehensive study of the Great War in the genre of intellectual history. The author reveals the course and various aspects of the First World War, relying on published during 1914-1941. sources created by its participants and contemporaries. The book also considers the historiographic reflection of the First World War in scientific studies of interwar times. The book is understood as a multi-level narrative, representing the totality and system of texts - actually author's, texts of sources and scientific works created during 1914-1941, as well as the hypertext of the book itself in the unity of its illustrative and textual component. The presented book is an example of a hybrid genre, combining historical narrative, source study and historiographic reflection, while being a vivid example of work in the paradigm of intellectual history. The author creates his own construction of historical memory of the First World War, which is in great demand in current socio-cultural and political realities.
RELAÇÃO ENTRE A EXPOSIÇÃO PRÉ-NATAL AO BISFENOL-A E O SURGIMENTO DE CÂNCER DE MAMA: REVISÃO INTEGRATIVA DA LITERATURA
Authors: Antunes Viana Felipe de Souza Princesa Jakeline , Laurentino Pereira Daniela , Karolline Valadares De Castro Helen , Dheyvison Nascimento Pureza Danilo
Published: December 2024

O Bisfenol-A (BPA) é um composto químico orgânico que pode afetar reações celulares, levando a anormalidades fetais, distúrbios metabólicos e alterações hormonais. A influência desse composto, especialmente em contato com o feto, tem sido associada ao surgimento de neoplasias mamárias devido ao mimetismo do BPA com hormônios análogos ao estrogênio, intensificando a proliferação celular e diminuindo a apoptose mamária. Nesse sentido, objetiva-se realizar uma revisão integrativa para buscar evidências entre a associação a exposição pré-natal ao BPA e a ocorrência de câncer de mama. Para o levantamento dos artigos na literatura, realizou-se uma coleta nas seguintes bases de dados: Biblioteca Virtual em Saúde (BVS) e United States National Library of Medicine (PUBMED). Os descritores e palavras-chave utilizados foram “Breast Neoplasms”, “Bisphenol” e “Prenatal Exposure”. Foram selecionados seis artigos, nos quais, notou-se que a exposição pré-natal ao BPA pode causar alterações morfologicas da glândula mamária, sendo que um estudo evidenciou tumorigênese precoce em camundongos transgênicos MMTV-erbB2, enquanto, três estudos descreveram alterações pré-cancerosas, um não encontrou alterações na morfologia mas demonstrou aumento na suscetibilidade e um descreveu aumento dos níveis de marcador tumoral. Em conjunto, os dados evidenciam que a molécula pode aumentar o risco de desenvolvimento de câncer de mama. Logo, as descobertas desta revisão ressaltam a necessidade de mais pesquisas com o intuito de elucidar os mecanismos pelos quais o bisfenol influencia a saúde mamária e para desenvolvermos estratégias de intervenção mais eficazes.
Conventional and Biological Direct Glycerol Fuel Cells: Review on Main Experimental and Model-Based Achievements
Authors: Pezzini Alessandra , de Sousa Júnior Ruy
Published: December 2024

There is a growing body of research on the use of liquid fuels in fuel cells, including glycerol.
The direct oxidation of glycerol in an abiotic (traditional, conventional) fuel cell can not only be
used to produce electrical energy, but also to obtain high value-added products. Furthermore,
recent experimental studies have employed glycerol in biological fuel cells, which could contribute
to transforming the biodiesel industry. Bacterial cultures have been used to degrade glycerol to
produce electricity, while enzymatic processes have also employed glycerol to produce electricity
and products of interest. This way, the main aim of this review is to survey the principal factors
influencing the use of conventional and biological (enzymatic and microbial) fuel cells. A summary
of the reports found in the literature is provided concerning the selectivity towards adsorbed
intermediates and products generated during the oxidation of glycerol in conventional fuel cells.
Not only experimental but also model-based aspects are addressed. For biological fuel cells, an
overview of the enzymes and microorganisms used is presented, in addition to addressing the
specific electron transfer mechanisms and other relevant aspects (such as challenges and limiting
parameters for function and performance).
Strategic Documents for Priorities and Prospects of Construction Industry in Russia
Authors: Musaev Rasul , Isaev Kirill
Published: December 2024

The priorities and prospects for the development of the construction industry in Russia depend on a set of strategic documents. The domestic construction industry is a promising area because the state needs to update and improve the housing stock. However, the current market instability indicates many potential risks. In this context, the strategy for the development of the construction industry becomes a priority because certain problem areas make it neither perfect nor effective: the construction industry requires strict state control and a new, unified pattern for strategic decisions. To date, the industry lacks systematic financing programs, which aggravates the situation as medium-sized construction businesses are gradually losing their positions, giving way to large companies. The construction industry has always been the most important element of the national economic system and the key engine of the Russian economy. However, it has accumulated negative phenomena that threaten its strategic development potential. In this regard, the industry needs basic strategic documents aimed at improving the standard and quality of life by providing affordable but high-quality housing. The article describes the opportunities and threats as the basis of the development strategy for the construction industry in Russia, as well as proposes a number of strategic directions that could improve the system of strategic documents.
The expression “ne po-russki” (“not in Russian”) as a language embodiment of national values in domestic media speech (according to the newspaper corpuses data)
Authors:   National Research Lobachevsky State University of Nizhny Novgorod, Radbil’ Timur B.
Published: December 2024

The work, based on extensive textual material, substantiates and aprobates a research model of cognitive-discursive analysis of the language embodiment of national values in words — representatives of the conceptual field “Russian”, functioning in the domestic media speech, according to newspaper corpuses data — using the example of an expression not in Russian. The research material is the contexts of use of expressions not in Russian, extracted from the newspaper corpus as part of the Russian National Corpus. Based on the results of the analysis of corpus data, it is shown that by using expressions not in Russian to characterize speech actions, facts of excessive or unjustified use of foreign language borrowings, as well as facts of illiterate, stylistically careless use of the Russian language, are negatively assessed. It has also been established that the use of expression non-Russian to characterize non-speech actions, states, relationships, situations acts as a representative context through which in discourse, using the “by contradiction” method, certain signs of value autostereotypes of the “Russian world” can be identified. Particular attention is paid to the somewhat mythologized ideas of Russian people about Russianness, which fit well into the ancient archetypal value opposition OWN — ALIEN, inherent in the “naive model of the world” of any culture at any stage of its development. In general, the results obtained demonstrated that in the naive model of the Russian world of values, only speaking Russian or behaving in Russian is recognized as the only correct thing. It is concluded that the expression not in Russian as a speech or behavioral characteristic often has a reference specifically to the speech or behavior of Russians, but in some sense, from the point of view of the native speaker, to incorrect patterns of speech or behavior that deviate from the national ideal.
Konkordatowa zasada współdziałania na rzecz obrony i poszanowania instytucji małżeństwa
Authors: Poniatowski Michał
Published: December 2024

W artykule jest przedstawiona analiza konkordatowej zasady współdziałania na rzecz obrony i poszanowania instytucji małżeństwa w zakresie polskiego porządku prawnego. W aspekcie komparatystycznym są również przedstawione wybrane normy zawarte w innych konkordatach współczesnych. Analiza dotyczy wpierw określenia stron współdziałania, w szczególności w kontekście możliwości interpretacji rozszerzającej poza same strony tej umowy międzynarodowej. Artykuł zawiera również określenie przedmiotu tego współdziałania, w tym w relacji do aktów normatywnych wyższego i niższego rzędu, w których także zawarto zobowiązanie do współdziałania. Analiza obejmuje również formę współdziałania na rzecz obrony i poszanowania instytucji małżeństwa zarówno w aspekcie bezpośrednim, jak i pośrednim. W zakończeniu zawarte są wnioski ogólne z przeprowadzonej analizy.
Piecza nad małoletnim dzieckiem oraz obowiązki alimentacyjne wobec niego w wyroku c. Caberletti z dnia 4 kwietnia 2017 roku
Authors: Kamiński Rafał
Published: December 2024

W artykule dokonano analizy jednego aspektu orzeczenia Roty Rzymskiej, a mianowicie powierzenia pieczy nad małoletnim dzieckiem i obowiązku alimentacyjnego wobec niego. Nie jest to sytuacja częsta gdy sąd kościelny wypowiada się na temat związany z zabezpieczeniem praw związanych z utrzymaniem potomstwa. Przedmiotowe małżeństwo, którego dotyczy wyrok zostało zawarte w Libanie, gdzie małżeństwa są możliwe tylko w formie wyznaniowej, stąd też w sprawach stanu osób i rodziny (Statut Personnel) obowiązuje prawo  związku wyznaniowego, do którego należą strony. Z tego powodu to sąd kościelny (w pierwszej instancji) zawarł w swoim wyroku postanowienia dotyczące pieczy nad małoletnim i zasądził alimenty na jego rzecz od ojca. W analizowanym wyroku rotalnym szczególnie interesujące było nie tyle samo rozstrzygnięcie, ile uzasadnienie prawne, na podstawie którego sąd do niego doszedł.
Pandemia COVID-19 a zdrowie psychiczne: nowy kontekst w procesach o stwierdzenie nieważności małżeństwa
Authors: Szymańska Kinga
Published: December 2024

W zaprezentowanym opracowaniu Autorka podjęła namysł nad problematyką nowatorską jaką jest wpływ pandemii COVID-19 na zdrowie psychiczne jednostki. Tak określony cel badawczy nie był celem samym w sobie, ale pozostawał we współzależności z innym pryncypialnym, mianowicie, czy choroba COVID-19 może rzutować na nieważność małżeństwa kanonicznego. Autorka na to pytanie odpowiedziała pozytywnie, wskazując, iż COVID-19 może destruktywnie wpłynąć na niezdolność konsensualną do zawarcia małżeństwa. W jej opinii sprawy w zależności od zaistniałych uwarunkowań powinny być prowadzone z jednego z tytułów ujętych w kan. 1095, n. 1-3 KPK.
Melão in natura como ingrediente em dietas para ovinos
Authors:   , Pinto Márcia Marcila Fernandes
Published: December 2024

O objetivo deste estudo foi avaliar o efeito da substituição de milho (MI) por níveis
crescentes de fruto-refugo de melão (FRM) (Cucumis melo L.), sobre o consumo de
nutrientes, digestibilidade, desempenho, rendimento de carcaça e qualidade da carne de
cordeiros em confinamento. Trinta cordeiros machos (não castrados) sem padrão racial
definido com peso corporal (PC) médio inicial de 22,68 ± 1,07 kg foram distribuídos em
cinco dietas contendo crescentes concentrações de FRM: zero, 25, 50, 75 e 100% em
substituição ao MI em relação à dieta total. Ao longo de 47 dias, foi realizada a mensuração
da ingestão e do desempenho dos animais. A substituição de FRM diminuiu linearmente
(p<0,05) o consumo de matéria seca, fibra em detergente neutro, carboidratos totais,
carboidratos não fibrosos assim como nutrientes digestíveis totais. O consumo de proteína
bruta foi influenciado de forma quadrática (p < 0,05) com a inclusão do melão na dieta. A
substituição do MI pelo FRM diminuiu linearmente (p < 0,05) os coeficientes de
digestibilidade da matéria seca, matéria orgânica, extrato etéreo, fibra em detergente neutro e
carboidratos totais, não sendo observada variação (p>0,05) quanto à digestibilidade da
proteína bruta e dos carboidratos não fibrosos. Houve também redução linear nos consumos
de energia digestível e de energia metabolizável (p<0,05). Da mesma forma o peso final
(p=0,040) e o ganho em peso médio diário (p=0,028) foram linearmente reduzidos em função
da substituição do MI pelo FRM. Apesar das reduções observadas no consumo e na
digestibilidade, nenhum componente da carcaça foi alterado em função das dietas avaliadas
assim como não se verificaram modificações nos parâmetros físico-químicos da carne
(p>0,05). Desta forma recomenda-se que o MI pode ser substituído em até 100% pelo FRM
já que não houve alterações no produto final carcaça e carne dos animais
The Contribution of the Rat Mesenteric Vascular Bed Model to
Phytopharmacology with Computational Studies of the Main Vasorelaxant
Phytochemicals
Authors: Zahi Amal , Kadi Mounime , Driouech Mounia , Ziyyat Abderrahim , Mekhfi Hassane , Bnouham Mohamed , Legssyer Abdelkhaleq
Published: December 2024

Background:

Hypertension, a major risk factor for cardiovascular disease, is often managed
with antihypertensive drugs. Medicinal plants are commonly used to control hypertension, and
many studies assess their antihypertensive effects using the rat mesenteric vascular bed model.

Objective:

This paper aims to highlight the value of the rat mesenteric vascular bed as a pharmacological
model for evaluating the vascular effects of medicinal plants with traditional antihypertensive
properties.

Method:

We reviewed 55 articles published between 1980 and 2022, using Scopus, PubMed, Web
of Science, and Google Scholar databases, focusing on medicinal plants studied in the rat mesenteric
vascular bed. Furthermore, we conducted a computational evaluation of the main vasorelaxant phytochemicals
derived from these plants.

Results:

We identified 63 species from 36 plant families evaluated in the mesenteric artery. Most of
these plants showed varying degrees of vasorelaxation due to vasorelaxant phytochemicals. The
mechanisms of vasorelaxation include angiotensin-converting enzyme inhibition, L-type voltagegated
calcium channel blockade, and activation of muscarinic (M3), and adrenergic (β2) receptors.
These experimental findings were supported by computational studies, which confirmed the potent
antihypertensive effect.

Conclusion:

The rat mesenteric artery remains a valuable model for studying the vascular effects of
plants and for developing new antihypertensive drugs.
SkyViewSentinel: A Deep Learning-Driven Military Object Detection Application for Remote-Sensing Satellite Images
Authors: Patil Aditya Nitin , Mohanty Sachi Nandan , Khan Tauseef
Published: December 2024

Background:

In today’s ever-changing world, military forces face significant challenges
in maintaining situational awareness and responding swiftly to emerging threats. Traditional
aerial surveillance often fails to give timely and thorough intelligence over large areas.
Limited coverage, mistakes, and difficulty noticing small changes on the ground hinder military
operations. To address these problems, this paper introduces the development of a deep
learning-based web application named “SkyViewSentinel”, a solution tailored specifically for
military aerial surveillance.

Methods:

The application framework i.e., SkyViewSentinel has been developed through multiple
stages i.e., (i) pre-process the Xview overhead Satellite imagery dataset using Ground
Truth refinement and image partitioning method, (ii) employed a SOTA deep model i.e.,
YOLOv8 as a baseline architecture for the research problem and assessed the performance on
experimental dataset, (iii) a series of rigorous experiments have been conducted using deep
model and obtained results are reported. (iv) Finally, the trained model has been seamlessly integrated
into the web application and develops a comprehensive web-based object detection
application. The developed application detects military-based objects from real-time satellite
images.

Results:

The developed application has shown promising results in identifying military objects
from satellite images, outperforming other contemporary methods. The designed framework
has achieved an overall mAP score of 0.315 for all nine classes of military-based objects. For
certain specific classes, detection accuracy exceeds 70%, demonstrating the robustness of the
framework.

Conclusion:

The designed web application enables users to detect military-based objects in the
region provided by the user. By harnessing the power of satellite object recognition technology,
SkyViewSentinel provides a new way to monitor and understand activities in operational
areas.
Development of Titanium Nitride-Based Coatings for Wear Resistant Materials: A Review
Authors: Margono  , Muhammad Kozin  , Setiadhi David , Hassan Khamis Hassan  , Rajeshkumar Lakshminarasimhan
Published: December 2024

Friction and wear are significant contributors to energy consumption, requiring the development of wear-resistant materials. Titanium nitride (TiN) coatings provide a potential solution for protecting metal parts from wear when they are applied over forming and cutting tools as TiN is characterized by low coefficient of friction and high hardness. However, local heat generation and brittle properties can cause cracks, affecting tool life and finished product accuracy. This article explores the wear behavior of TiN-based coatings over the substrates. In most cases, the TiN coatings are applied using Physical and Chemical Vapor Deposition (PVD and CVD), and duplex treatment methods. PVD and CVD techniques have been the preferred processes for years for the deposition of various industrially important coatings, with the typically producing single coatings like ceramics or intermetallics. This study concludes multilayer or multiphase coating can improve fracture resistance, acting as a crack inhibitor and improving tribological properties. Duplex treatment shows potential for future advancements and has been developed to address these issues and extend PVD and CVD processes' commercial viability.
Cell factories for sustainable production of valuable chemicals – the pivotal role of Saccharomyces cerevisiae
Authors: Silva Paulo César , Johansson Björn
Published: December 2024

The green economy aims to substitute polluting chemicals and processes with sustainable counterparts deriving from microbial cell factories that provide catalytic specificity and efficient conversions. In this manuscript, we explore how the bio-based production of chemicals enables the production of valuable molecules while reducing contemporary society's dependence on fossil fuels thereby alleviating part of the environmental burden. We discuss several emerging bio-based solutions and their impacts, with a particular focus on the potential of the yeast Saccharomyces cerevisiae in leading industrial microbial fermentation. Yeast remains a versatile, productive, and robust platform for producing metabolites and recombinant proteins.
Social justice pedagogy: International perspectives on Collaborative Online International Learning (COIL) through a World Café engagement
Authors: Collett Karen S. , Slapac Alina
Published: December 2024

The promotion of social justice pedagogy in Collaborative Online International Learning (COIL) courses and virtual exchange (VE) programs has gained traction in the last decade, as opportunities for faculty and students to participate as equal partners in the internationalization of the curriculum have grown. This practice report highlights the processes and outcomes of critical engagement through an interactive World Café workshop at the 2023 IVEC conference in São Paulo, Brazil. The participants were a group of 45 international faculty and COIL coordinators from various higher education institutions. Nancy Fraser’s (2008; 2009) normative framework related to social justice was used to facilitate a critical discussion related to the economic, cultural, and political dimensions of their COIL courses in supporting participatory parity. Key trends, questions, and recommendations for enhancing social justice pedagogy were identified. These findings may provide a springboard to engage colleagues in further dialogue that could promote awareness around social justice pedagogy and participatory parity through COIL.
Koncepcja radomskiej kolei aglomeracyjnej w kontekście najnowszych inwestycji infrastrukturalnych
Authors: Drąg Bartłomiej
Published: December 2024

Artykuł stanowi próbę nakreślenia autorskiej koncepcji obsługi koleją regionalną/podmiejską podregionu radomskiego NUTS 3, zwaną na potrzeby niniejszego artykułu radomską koleją aglomeracyjną. Przedstawiono także potencjał ludnościowy podregionu radomskiego. Ważnym elementem jest opis zrealizowanych i planowanych inwestycji infrastrukturalnych, które umożliwią lepsze funkcjonowanie kolei regionalnej/podmiejskiej. W artykule zawarto także podział na różne kategorie pociągów obsługujących linie kolejowe podregionu radomskiego. Określone są one przez zasięg połączeń oraz pożądaną częstotliwość kursowania w danej relacji. Koncepcja opiera się przede wszystkim na wykorzystaniu istniejącej infrastruktury. Proponuje się także jej uzupełnienie o pewne elementy zawarte w podrozdziale „Propozycja uzupełnienia infrastruktury kolejowej”.
Słowa kluczowe: kolej, podregion radomski, pociągi regionalne/podmiejskie, inwestycje kolejowe