bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative study of data from geotechnical field penetration tests on sandy subsoils
Authors: dos Santos Mirella Dalvi , Bicalho Kátia Vanessa
Published: March 2022

The main objective of the work reported in this paper was to compare standard penetration test (SPT), dynamic probing (DP) and cone penetration test (CPT) data for uniformly graded sandy soils located in the southeast Brazilian coastal region of Grande Vitória, Espírito Santo (GV-ES). Previously reported datasets of laboratory and field penetration test data concerning the variations of some soil parameters associated with the investigated correlations were also evaluated. The correlations analysis addressed the influences of textural characteristics, especially grain size distribution, and relative density on the obtained CPT–SPT and DP–SPT linear correlations using a newly compiled experimental database for GV-ES sands and the previously published datasets. Correlations were determined using statistical inference, specifically by simple linear regression and analysis of residues for several groups of experimental data.
The 75th birthday of Alexey Vasil’evich Belyakov
Authors: Editorial Article
Published: March 2022

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Analysis of influence of loading scheme on the stress state of the surface layer of Al2O3‒TiCceramics with AlN and TiN coating
Authors: Kuzin V. V. , Grigor’ev S. N. , Volosova М. М. , Fedorov M. Yu.
Published: March 2022

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Study of metal-ceramic coatings formed by carbo-vibroarc hardening containing nanosized Al2O3
Authors: Titov N. V. , Kolomeychenko A. V. , Basinyk V. L.
Published: March 2022

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Composition and technology of applying a refractory coating for wood using a nanoscale filler
Authors: Savel’ev A. P. , Chugunov M. N. , Enaleeva S. A. , Kravchenko I. N.
Published: March 2022

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An innovative way of active thermal protection of pipelines for moving hot bulk materials and cylindrical apparatus
Authors: Davydov S. Ya. , Makarov V. N. , Kozhushko G. G. , Makarov N. V. , Ugolnikov A. V.
Published: March 2022

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Obtaining porous ceramic silicon carbidebased converters for ethylbenzene dehydrogenation in styrene
Authors: Uvarov V. I. , Kapustin R. D. , Fedotov A. S. , Kirillov А. O.
Published: March 2022

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Ensuring safety in the development of bauxite mines
Authors: Davydov S. Ya. , Apakashev R. A. , Valiev N. G. , Startsev V. A.
Published: March 2022

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Development and application of SHS nitride ferrosilica to increase the resistance of the vomits of domain furnaces
Authors: Manasheva E. M. , Manashev I. R. , Zathdinov M. Kh. , Makarova I. V.
Published: March 2022

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Development of the method of drug-containing waste by heat treatment in a reducing atmosphere
Authors: Khaidarov T. B. , Kozaev А. А. , Khabibulin Е. Е. , Khaidarov B. B. , Suvorov D. S. , Lysov D. V. , Kuznetsov D. V. , Burmistrov I. N.
Published: March 2022

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Improvement of thermal operation of mine furnace for asbestos raw material drying
Authors: Matykhin V. I. , Matykhina A. V. , Punenkov S. E.
Published: March 2022

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Dual Action Mechanism of Insulin Resistance and Insulin Secretion by Imeglimin for Diabetic Treatment
Authors:   Japan Low Carbohydrate Diet Promotion Association (JLCDPA), Kyoto, Japan and Tokushima University, Medical Research, Nakashowa 1-61, Tokushima 770-0943, Japan, Bando Hiroshi
Published: March 2022

Imeglimin (Twymeeg) is novel oral hypoglycemic agent (OHA) developed in the glimin category. It has dual action mechanisms of reducing insulin resistance and increasing insulin secretion. Trials of imeglimin for efficacy and safety 1 (TIMES 1), TIMES 2 and TIMES 3 were performed with significant clinical efficacy. Among them, HbA1c decrease for 52 weeks showed single imeglimin -0.46%, combined therapy of dipeptidyl peptidase-4i (DPP-4i)-0.92%, Glucagon-like peptide-1 receptor agonists (GLP-1RA)-0.12% and insulin -0.63%. From physiological and pharmacological points of view, the mechanism may include the enhancement action of glucose-stimulated insulin secretion (GSIS). For GSIS progress, transient receptor potential melastatin 2 (TRPM2) channel is activated.
CONSTITUTIONALISM AND PUBLIC HEALTH EMERGENCIES: COVID-19 REGULATIONS IN SOUTH AFRICA AND THE CONSTITUTIONAL AND HUMAN RIGHTS SLIPPERY SLOPE
Authors: Annie Singh  , Simbarashe Tembo
Published: March 2022

This article provides a theoretical and factual-legal analysis of South Africa’s response to the COVID-19. The state of disaster and its related COVID-19 regulations are interrogated from a constitutional and human rights perspective. It is conceded that public health emergencies call for a limitation of certain rights to control or curb the spread of the pandemic. However, the measures adopted by the South African government were in some respects disproportional and violated the constitutional and human rights principles. This article carefully examines the South African approach in instances where the constitutional and human rights of its people were brought into contention. For purposes of clarity, the focus is on documented accounts of the violations of fundamental human rights during the declaration and the operation of Lockdown Regulations in terms of the Disaster Management Act 2002.
Methodology for Determining the Speed‑Power Capabilities of Basketball Players
Authors: Koryahin Viktor , Hrebinka Halyna , Prystynskyi Volodymyr , Prystynska Tetyana
Published: March 2022

The study objective is to develop a methodology for determining the jump height and jumping endurance in basketball players of various gaming functions using modern nanotechnology and microprocessor systems, in particular smartphones, personal computers, etc.

Materials and methods. The study used a method for determining jump height and jumping endurance using capacitive sensor devices based on a combination of modern nanotechnology and microprocessor systems, in particular smartphones, personal computers.

Results. The study showed that the use of modern nanotechnology to monitor the jump height and jumping endurance allows you to study these indicators with high accuracy, which is very important in scientific research. The study showed that the absolute height of the jump in center players is 328.1 ± 7.88 cm, in attackers – 324.1 ± 6.62 cm, in defenders – 314.4 ± 8.65 cm. The relative height of the jump in defenders is 57.7 ± 6.86 cm, which is on average 8.2 cm more than in center players, and 5.3 cm more than in attackers (p < 0.001 and p < 0.02, respectively).

Conclusions. The use of modern nanotechnology and microprocessor systems to determine the parameters of jump height and jumping endurance allows you to determine these parameters with high accuracy. The use of modern, accurate nanotechnology measurement and calculation of jump height and jumping endurance indicators using graphic data analysis provided a complete description and degree of development of various “jumping” qualities of basketball players.

Studies have shown that the jump height and jumping endurance in basketball players of different roles (defenders, attackers, and center) differ with a high degree of reliability.
The Effect of Training Based on Part And Whole Combinations on Smash Techniques Improvement in Volleyball Sports for 11-12 Year Old Athletes
Authors: Wicaksono Danang Wicaksono , Hidayatullah Furqon , Kristiyanto Agus , Purnama Sapta Kunta
Published: March 2022

Objective. This study aims to examine the effectiveness of the part and whole combination-based smash training model on smash techniques in volleyball athletes aged 11-12 years.  Materials and method. This study used an experimental field testing method, with a pretest-posttest control group design approach. The participants were 52 male volleyball athletes aged 11-12 years and had an average weight and height of ±36.02 kg and ±144.63cm. The instrument used to measure the smash technique was a volleyball skill test.  Results. The results of the descriptive analysis showed differences in the mean and standard deviation of the conventional group and the experimental group. The average value of the conventional group is 75.562 with a standard deviation of 8.7956, while the average value of the experimental group is 87.492 with a standard deviation of 1.9343. Hypothesis testing conducted using Mann-Whitney analysis found that the value of Asymp sig (2-tailed) was 0.000 <0.05, which indicates that the hypothesis is accepted.  Conclusions. Knowing the descriptive results and hypothesis testing, it is concluded that the experimental group experienced a significant improvement and was better than the conventional group. Based on the category of posttest average result assessment, the experimental group was included in the very good category. In other words, the experimental group was very competent. On this basis, this research can be used as a reference in training smash techniques for volleyball athletes at the beginner age.
Russian Schools during the COVID-19 Pandemic: Impact of the First Two Waves on the Quality of Education
Authors: Chaban Tatyana , Rameeva Roza , Denisov Ilya , Kersha Yuliya , Zvyagintsev Roman
Published: March 2022

International studies about the impact of the COVID-19 pandemic on the quality of general education have yielded contradictory results: educational outcomes have fallen markedly in some countries while remaining more or less constant in others. At the same time, over half of published studies attest to the growth of educational inequality during the pandemic. The present article assesses the impact of the pandemic using the data of a regional monitoring study of all schoolchildren in grades 4, 6 and 8 in the Krasnoyarsk Region in 2019 and 2021. Tests of reading literacy in grades 4 and 6 as well as of science literacy in grade 8 have shown the satisfactory psychometric quality. Multilevel regression analysis was used to show that the level of functional literacy of the “pandemic” cohort of schoolchildren, controlled for contextual characteristics, was significantly lower for students in all grades except grade 4. The biggest loss was found for scientific literacy. No correlation was found between the pandemic effect size and the socioeconomic composition of the class (the gap between children with different SES remains at the same level as it was before the pandemic). The teachers’ opportunity to conduct online classes did not serve to improve the educational outcomes of schoolchildren during the pandemic.
Digital Transformation of Schools and Student’s Information and Communication Literacy
Authors: Avdeeva Svetlana , Uvarov Aleksander , Tarasova Ksenia
Published: March 2022

Information and communication literacy is one of the main meta-subject competencies that graduates of the secondary school should possess. The full-fledged formation of this competence is considered as one of the tasks of preparing students for life in the information society and the digital economy. The article discusses the results of a monitoring study of the information and communication literacy of 9th grade students, which was conducted in 21 regions of the Russian Federation in 2020. About half (45.4%) demonstrated a level of competence that corresponds to the readiness for life in the digital economy. Was considered the influence of the equipment of schools and the peculiarities of the organization of educational activities on the students’ level of information and communication literacy (ICL). The results of the study indicate a strong connection between the students’ competence and their out-of-school environment and a weak — with their work in the school. Research findings allow to determine the reasons for the insufficient level of ICL in a significant part of graduates and used to propose recommendations for its increase.
Parallel DNA+RNA extraction from freshwater samples using the Quick-DNA/RNA Microprep Plus Kit and Zymo-Spin II-µHRC Filters (Zymo Research) v1
Authors: A Hempel Christopher
Published: March 2022

Parallel DNA+RNA extraction from freshwater samples using the Quick-DNA/RNA Microprep Plus Kit and Zymo-Spin II-µHRC Filters (Zymo Research) Note: maximum of 11 samples + extraction control possible at a time
[RETRACTED] Keto Now Canada Shocking Report Reveals Must Read Before Buying v1
Authors: not provided officialketonowca
Published: March 2022

[RETRACTED]

Keto Now Canada is an all-natural weight loss supplement designed to help you burn fat through the proven science of ketosis.
[RETRACTED] ACV Super Slim Gummies - Get Off The Weight Loss Cycle For Good & TRY Tasty Gummies v1
Authors: Super Slim Gummies UK ACV
Published: March 2022

[RETRACTED]

ACV Super Slim Gummies - Get Off The Weight Loss Cycle For Good & TRY Tasty Gummies
LİSE ÖĞRENCİLERİNİN TEKNOLOJİ KULLANIM, MUTLULUK VE MOBİL ÖĞRENME HAZIR BULUNUŞLUK DÜZEYLERİNİN İNCELENMESİ
Authors: Gökbulut Bayram , Kılıç Fatma
Published: March 2022

Bu çalışma ile öğrencilerinin teknoloji kullanım, mutluluk ve mobil öğrenme hazır bulunuşluk düzeyleri arasındaki ilişki ortaya konulmaya çalışılmıştır. Çalışma 2020-2021 akademik yılında, Batı Karadeniz Bölgesi’nde yer alan bir ilde yürütülmüştür. Araştırmaya 683 lise öğrencisi katılmıştır. Verilerin toplanmasında “Mobil Öğrenme Hazırbulunuşluk Ölçeği”, “Teknoloji Kullanım Ölçeği” ve “Oxford Mutluluk Ölçeği” olmak üzere üç adet ölçek kullanılmıştır. Ölçeklerden elde edilen veriler ile lise öğrencilerinin teknoloji kullanım, mutluluk ve mobil öğrenme hazır bulunuşluk düzeyleri arasındaki ilişki ile cinsiyet, okul türü, sınıf ve internet kullanım süreleri arasındaki farklar araştırılmıştır. Araştırma sonunda, “Mobil Öğrenme Hazırbulunuşluk Ölçeği” alt faktörü olan öz-yeterlik, mutluluk ve teknoloji kullanımı ile cinsiyet faktörü arasında erkekler lehine anlamlı bir fark bulunmuştur. Teknoloji kullanım, mutluluk ve mobil öğrenme hazır bulunuşluk düzeyleri ile okul türü ve sınıf değişkeni arasında anlamlı bir farka rastlanmamıştır. Teknoloji kullanım ve mobil öğrenme hazırbulunuşluk düzeyleri ile internet kullanım süresi arasında anlamlı farka rastlanmıştır. Günlük 3-7 saat ve üzeri internet kullanan öğrencilerin Teknoloji Kullanım ve Mobil Öğrenme Hazırbulunuşluk düzeyleri, günlük 0-2 saat arasında olan öğrencilerden daha yüksek olduğu sonucuna ulaşılmıştır. Lise öğrencilerinin teknoloji kullanım, mutluluk ve mobil öğrenme hazır bulunuşluk düzeyleri arasındaki orta düzey pozitif yönlü bir ilişkiye rastlanmıştır
Extrafocal osteosynthesis using anchor-pin device for the treatment of united fractures and pseudoarthroses of humerus
Authors: Afaunov A. A. , Afaunov A. I.
Published: March 2022

Extrafocal Osteosynthesis using monolateral anchorpin device is suggested for the treatment of patients with ununited fractures and pseudoarthroses of the humerus. The main transosseous element of the device are the anchor bunches of two or three pins the tips of which perforate the soft tissues and the underlying cortical layer of the bone fragments from only one side. Intraosteally the pins form the angle of 60 - 100. Fiveor sixmillimeter rods could serve as the repositioning elements. The outer construction of the device is presented by pin-holders of three types, threading bars of different length, external reposition unit, rectangular strips and the arms for the mounting of repositioning rods. The device is compact and possesses high potentialities for reposition. The device provides reliable osteosynthesis and thus enables the early postoperative loading of the extremity. The method was used for the treatment of 24 patients with ununited fractures and 36 patients with pseudoarthrosis of the humerus. Longterm results (one year after operation) are studied in 17 and 26 patients, respectively. In ununited fractures good results are obtained in 82.3% and satisfactory in 17.7% of cases, in pseudoarthrosis - in 80.8% and 19.2%, respectively.
Extraosseous compression-dynamic osteosynthesis for the treatment of forearm bone fractures
Authors: Zorya V. I. , Lirtsman V. M. , Ulyanov A. V.
Published: March 2022

Special plate is suggested to provide extraosseous compression-dynamic osteosynthesis. The plate consists of two parts: base and rack. Longitudinal shift of the rack relative to the base is made by the rotation of the key which has a gear tenon on its end. The tenon and base are connected by gear transmission. Shift of the rack enables to put two bones fragments nearer and achieve their tightness and compression. Conditions for fracture healing are obtained.
Biorhythms of bone tissue metabolic processes and diagnostic evaluation by dexa
Authors: Kornilov N. V. , Avrunin A. S. , Sinyukova I. V. , Kazemirsky V. E.
Published: March 2022

Fifty two patients with dysplastic coxarthrosis, aged 14-23, were examined using dual photon X-ray absorptiometry. Changes in bone mineral density had fluctuating pattern. On the base of experimental data a calculating experiment was performed. It showed that coincidence of trend direction obtained at random with true tendency defined by approximation of all dynamic row was only 58% in reiterated examination, 63% - in thrice-repeated examination and 69% - in five -times examination. Hence, even five-times examination is not enough for the exact diagnosis of metabolic disturbances of bone tissue and objective control of the effective treatment and more examinations are required.
Generic-To-Reference Rock Scaling Factors for Seismic Ground Motion in Italy
Authors: Lanzano Giovanni , Felicetta Chiara , Pacor Francesca , Spallarossa Daniele , Traversa Paola
Published: March 2022

In this article, we apply the reference-rock identification method (RRIM; Lanzano et al., 2020) to the ITalian ACcelerometric Archive, which includes more than 1600 recording stations in Italy and in the neighboring countries, with different levels of site characterization. The RRIM is based on the identification and the evaluation of site parameters representing the reference site conditions (Steidl et al., 1996) and the construction of the scoring scheme to classify the candidate stations. Given the large number of sites, the preselection of candidates is performed via residual analysis, selecting those characterized by flat site response and amplitude similar or lower than the one for the generic rock (average shear-wave velocity in the uppermost 30 m, VS30=800  m/s). The main results of this study are: (1) a list of reference rock sites in Italy, with an associated score; (2) a scenario-independent generic-to-reference rock corrective factor for the ground-motion model for shallow active crustal events in Italy (ITA18; Lanzano, Luzi, et al., 2019); (3) a model for the generic-to-reference rock corrective factor, parametrized in terms of VS30 and κ0, that is, the high-frequency decay parameter (Anderson and Hough, 1984). A collateral product is a set of coefficients for the prediction of 81 ordinates of the Fourier amplitude spectra (FAS) in the frequency interval 0.1–30 Hz, calibrated with the same dataset and functional form of ITA18 for acceleration response spectra (SA). The application of RRIM allowed us to identify 116 stations with average measured VS30∼900  m/s. The corrective factor allows to scale both SA and FAS spectra, and has a significant effect at high frequencies, reducing the ground motion by up to a factor 1.7 at f = 10 Hz. The introduction of κ0 in the corrective term modeling is effective from 2 Hz onward and results in a reduction of variability at high frequencies (f > 10 Hz).
The 21 May 2021 Mw 6.1 Yangbi Earthquake—A Unilateral Rupture Event with Conjugately Distributed Aftershocks
Authors: Chen JunLei , Hao JinLai , Wang Zun , Xu Tao
Published: March 2022

An Mw 6.1 earthquake occurred in Yangbi, Yunnan province, China, at 13:48:34 (UTC time) on 21 May 2021. It exhibited a typical foreshock–mainshock–aftershock sequence in the northwestern Yunnan rifting area. We used the first P-arrival time from regional broadband seismic stations to check the location of the mainshock’s hypocenter. The updated location of the epicenter is 99.88° E, 25.66° N. The focal mechanisms of nine earthquakes, including the mainshock and the largest foreshock and aftershock, were investigated using the general cut-and-paste method based on regional seismic waveforms to set up the fault geometry and to calculate the static coulomb stress change. The rupture process of the mainshock was constrained by 33 unclipped regional broadband seismic records from 15 stations and nine static displacements from three Global Navigation Satellite System stations. The results showed that the Yangbi earthquake was a unilateral rupture event propagating toward the southeast along-strike direction. The moment was 1.81×1018  N·m, and the corresponding magnitude was Mw 6.1. The peak slip value, the weighted rupture velocity, and the duration time of the mainshock were 0.95 m, 2.2 km/s, and 9.1 s, respectively. At 10 km southeast of the mainshock’s epicenter, the conjugately distributed aftershocks were observed, and the moment density of the mainshock along the strike direction decreased sharply (78% of the total moment released in the first 10 km), suggesting that the sharply decelerating rupture could be the reason for the conjugately distributed aftershocks. The changes in static coulomb stress due to the largest foreshock and mainshock were calculated. The results showed positive Coulomb stress on the major slip zone in the mainshock fault plane triggered by the largest foreshock. Moreover, the 0.01 MPa contour due to the mainshock radiated out of the bend zone of the Weixi–Qiaohou–Weishan fault.
Recent Intraplate Seismicity in Estonia, East European Platform
Authors: Soosalu Heidi , Uski Marja , Komminaho Kari , Veski Anu
Published: March 2022

Four Estonian earthquakes were studied, 1.2–2.0 in magnitude and taking place in 2016–2018. Their focal parameters were determined, providing an opportunity to place them in the context of the regional stress field and make tentative geological interpretation of their connection to faults in the Precambrian basement, which is overlain by a 100–600 m thick sequence of sedimentary bedrock. Such research was made feasible by augmenting the permanent three-station Estonian seismic network with seven temporary stations. The analyzed earthquakes were compared with the largest known Estonian earthquake, the 1976 magnitude 4.5 Osmussaar earthquake. The results indicate that it is possible to consider all the five events as expressions of predominantly left-lateral strike-slip movement on north-northwest–south-southeast subvertical faults in concert with the general stress field of northern Europe, which is dominated by plate movement.
A Short-Period Surface-Wave Dispersion Dataset for Model Assessment of Africa’s Crust: ADAMA
Authors: Olugboji Tolulope , Xue Siyu
Published: March 2022

We present the first in a series of dataset and model assessment products for investigating Africa’s lithosphere (ADAMA). This is a comprehensive catalog of short-period interstation surface-wave dispersion measurements and uncertainties. It is derived from processing continuous recordings of all publicly available three-component seismograms, spanning four decades, from ∼1372 stations, across 62 seismic networks deployed in and around the African continent. It includes Love- and Rayleigh-wave dispersion derived from frequency-domain ambient noise cross-correlation functions (NCFs). Phase and group dispersion, as well as their uncertainties, are then obtained with an iterative nonlinear waveform fitting of the NCFs, using a spectral element representation of a path-average a priori Earth model. Our catalog represents the following advances: (1) a large distribution of short period dispersion measurements: ∼114,000 interstation pairs at periods between 5 s and 40 s, (2) inclusion of uncertainties useful for regularization in continent-wide model building, (3) preliminary model assessments for different tectonic domains on the continent, and (4) an exemplary Love-wave phase velocity map obtained by Bayesian inversion revealing detailed features not previously detected. ADAMA will be used to prepare short-period, high-resolution dispersion maps, and for assessment and updates of widely used seismic velocity models of the crust across a diversity of terranes on the continent.
Sorption of organic chemicals on natural organic matter in the water column and effects on the toxicity of the chemicals to Daphnia magna
Authors:   , Henry Linda , Suffet Irwin H.
Published: March 2022

The sorption potential of hydrophobic synthetic chemicals on dissolved (DOM) and particulate organic matter (POM) in natural waters was measured, and the effect of sorption by DOM on the toxicity of the chemical to an aquatic organism, Daphnia magna, was determined. The fraction of benzo(a)pyrene (BaP) bound to the DOM > 1000 daltons at salinities from 0 to 22 ppt was measured using dialysis in water from the Delaware River Estuary. The partition coefficient, Kdom, calculated with DOM > 1000 daltons gave the best fit of the data (r2 = 92). Linear regression analyses showed no significant effect of salinity on Kdom or on the concentration humic acids. Acute toxicity, tissue concentrations and Kdom values were determined for DDT and lindane using Daphnia magna with and without humic acid DOM. Kdom values, determined with changes in BCF, agreed with published values using dialysis methods. Treatments with DOM added were all significantly less toxic than in water alone. However, there was no difference due to DOM when toxic response to DDT was plotted against tissue concentration. The toxic response and tissue concentration for lindane were not affected by DOM. The results indicate that chemicals sorbed on DOM are not toxic because bound forms are not available for uptake by aquatic organisms. Sorption by DOM and POM was measured in surface waters and in leachates from soils and sediments for two PCB's, lindane, dieldrin and p,p' DDT. Kdom values were measured with changes in dry weight BCF for Daphnia magna and Kpom values were measured with centrifugation. The relationship of log Kdom to log Kow for the chemicals in this study agreed closely with published values for sorption of chemicals by soils/sediments. This indicates that organic material in the water column sorbs chemicals to the same degree as organic material in soils/sediments.
Interactions of [psi]-conotoxin PrIIIE with the muscle-type nicotinic acetylcholine receptor
Authors:   , Hernandez-Cuebas Lisa , White Michael M
Published: March 2022

Conotoxins are peptide toxins present in the venom of Conus marine snails. There are over 500 species of Conus giving rise to over 50,000 different peptide toxins. These toxins are highly selective for various ligand-gated and voltage-gated ion channel subtypes. Conotoxins have proven to be useful tools to probe the functional domains of ion channels. In addition, they can be used as therapeutic agents to target specific ion-channels. Conotoxin PrIIIE is a 22-amino acid peptide from the venom of Conus parius Reeve containing three disulfide bonds. It is a member of the [psi]-conotoxin family which targets the nicotinic acetylcholine receptor (nAChR). In this thesis, we demonstrate that PrIIIE is a non-competitive inhibitor (NCI) of the mouse muscle-type nicotinic acetylcholine receptor using an electrophysiological assay of receptors expressed in Xenopus oocytes. In addition, we developed a recombinant expression system to produce a biologically-active PrIIIE in Escherichia coli. We fused the coding sequence of PrIIIE to that of the small ubiquitin-like modifier (SUMO) and expressed the fusion protein in an E. coli strain with an oxidizing cytoplasm. We purified the fusion protein by immobilized metal affinity chromatography and further purified PrIIIE from cleaved SUMO using cation exchange chromatography. The recombinant peptide is functional, as demonstrated by two-electrode voltage clamp experiments. We used site-directed mutagenesis to create PrIIIE mutants and our recombinant expression system to produce them, and then tested the activity of the mutants using electrophysiological assays. Mutation of glutamate 14 to glutamine (E14Q) increases the apparent affinity of PrIIIE by ~3.5 fold. Lysine 19 and tyrosine 20, in loop 3, are not individually important for PrIIIE to inhibit the nAChR. Mutation of both arginines in loop 3 to serines (R17SR18S) resulted in a loss of activity for PrIIIE. We determined that only one positively charged arginine, either R17 or R18, but not both, is required for PrIIIE to inhibit the nAChR. We have identified key residues important for the inhibition of the mouse nAChR by PrIIIE. Future work includes identifying other residues important for PrIIIE to inhibit the nAChR and elucidating the mechanism of action for PrIIIE as a NCI.
Rec.: Library Design for the 21st Century: Collaborative Strategies to Ensure Succe, Edited on Behalf of Ifla by Diane Koen and Traci Engel Lesneski. Berlin, Munich: De Gruyter Saur, 2019, SS. 236.
Authors: Jaworska Monika Maria
Published: March 2022

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Wkład słuchaczy Szkoły Głównej w Warszawie w rozwój bibliografii polskiej
Authors: Matczuk Alicja
Published: March 2022

Streszczenie: Szkoła Główna w Warszawie (1862–1869) mimo krótkotrwałej działalności wykształciła wielu wybitnych bibliografów, którzy wnieśli trwały wkład w rozwój bibliografii i nauki polskiej. Do grona tego należeli m.in.: Adam A. Kryński, Piotr Chmielowski, Stanisław Czarnowski, Feliks Kucharzewski i Adolf Suligowski. Prowadzone przez nich badania bibliograficzne, w ujęciu ogólnym i specjalnym, przyczyniły się nie tylko do stworzenia podstawy rozwoju niektórych dyscyplin naukowych, ale także do kształtowania świadomości i kultury bibliograficznej społeczeństwa polskiego. Specjalnością słuchaczy Szkoły Głównej były bibliografie dziedzinowe tworzone na potrzeby naukowe, jak również z pobudek patriotycznych. Ich działalność bibliograficzna znalazła rozwinięcie w okresie międzywojennym. W nurcie zainteresowań bibliograficznych słuchaczy Szkoły były także bibliografie zawartości czasopism, osobowe i zagadnień. Ich dokonania na gruncie bibliografii polskiej miały z reguły charakter pionierski,
gdyż w szerokim i retrospektywnym ujęciu rejestrowały bogaty materiał dotyczący przeszłości Polski. Trzeba też docenić wysiłek słuchaczy Szkoły Głównej, którzy mimo bardzo trudnych warunków politycznych starali się stworzyć odpowiedni warsztat bibliograficzny, warunkujący rozwój poszczególnych dyscyplin naukowych. Swego rodzaju ewenementem w skali kraju był fakt, że grono słuchaczy Szkoły Głównej zdominowało działalność bibliograficzną w ujęciu dziedzinowym i zagadnieniowym w drugiej połowie XIX i na początku XX w. Zawdzięczamy im pierwsze polskie bibliografie dziedzinowe z zakresu archeologii, językoznawstwa, techniki czy prawa, które stanowią do dziś ważny element warsztatu naukowego badaczy.
Female entrepreneurship: Evidence-based high-impact perspective from Chile and Peru
Authors: Huamán Fátima , Guede Belén , Cancino Christian A. , Cordova Miguel
Published: March 2022

This study aims to highlight cases of women-led business (WLB) that achieved high-growth in the short term, contradicting the traditional approach of female entrepreneurship associated with precariousness. This paper uses a multiple case study, exploring examples of WLBs in Chile and Peru. The results show some entrepreneurial behavior patterns among WLBs, such as experience in the field, growth-oriented strategy, service innovation, accelerated expansion, high-quality products, and a particular attitude toward entrepreneurship. This study shed additional light on how some WLBs are not linked to subsistence or low-impact, as well as how public policies must support high-growth WLBs.
A Bibliometric Analysis of the Scientific Production of e-Learning in Higher Education (1998-2020)
Authors:   Universiti Putra Malaysia, Malaysia, Gao Yanjun , Wong Su Luan , Khambari Mas Nida Md. , Noordin Nooreen
Published: March 2022

Studies on E-learning in higher education have been gaining increasing attention from scholars in recent years. To have an overall understanding of these scientific productions of E-learning, a bibliometric analysis was done to conduct a quantitative scientific analysis of 1985 journal articles collected from the Scopus database. All the documents were analyzed through Biblioshiny and VOSviewer software. The results revealed that publications on E-learning increased at an exponential speed with a 26.48% annual growth rate. The International Journal of Emerging Technologies in Learning was the most productive while Computer and Education was considered the most impactful journal based on total citations. Europe and the United States played the leading role by publication quantity and total citations. At the researcher level, Al-samarraie, H. was ranked the top author in terms of both productivity and h-index, while Ebner, M. was the most influential author by total citations. The main themes drawn from the cluster analysis were “distance learning”, “technology acceptance”, “teachers’ professional training and development” and “quality assessment of E-learning”, which confirmed further previous research themes. The limitations of the study and recommendations for future research conclude the paper.
An analysis of the levels of delay seen in maternal near miss cases in India
Authors: Chainani Esha G. , Nandanwar Yogeshwar S.
Published: March 2022

Background: The measure of progress of maternal health has usually been a reduction in maternal mortality but if you look at maternal health as an iceberg – maternal deaths are only seen as the tip, with maternal morbidity as the base. As for every woman that dies of maternal causes, 20-30 others experience severe maternal morbidity, sometimes with permanent consequences affecting their daily functioning.Methods: We conducted a prospective observational and clinical study at D. Y. Patil Hospital in Navi Mumbai, India from November 2018 to October 2020 from critically ill, pregnant, laboring, post-partum or post-abortal women that were admitted to the hospital and the levels of delay and barriers to health were carefully asked from the proforma and tabulated.Results: The most common cause of delay was delay 1 in 48.6% cases followed by delay 2 in 31.9% patients. 18.1% patients had no delay noted followed by 1.4% patients that had a level 3 delay. This study found significant association with antenatal care with type of delay experienced during maternal near miss. Women that had not taken appropriate antenatal care in pregnancy had a higher association to type 1 delay.Conclusions: We have learnt that social determinants are important contributors to the causes of near miss delays and eventual maternal mortalities and these social determinants depend on many social levels. Addressing maternal deaths requires action at every level, not just medical or health services. Understanding the delays in receiving care helps analyze patterns of maternal near miss cases and consequently maternal deaths.
Analysis of the prevalence, etiology, and risk factors of stillbirth from a teaching institute of North Eastern India- a retrospective study
Authors: Das Rituparna , Sharma Nalini , Lyngdoh Bifica S. , Panda Subrat , Saha Anusmita , Shullai Wansalan K. , De Biswajit
Published: March 2022

Background: Stillbirth rate is considered a health index. The worldwide stillbirth rate is 18.4/1000 total birth. This study was aimed to evaluate the prevalence and risk factors of intrauterine fetal death in pregnant women in one of the teaching centers in Northeastern India.Methods: This was a retrospective study. All cases of intrauterine fetal death admitted in the department of obstetrics gynecology of our institute were included over two and half years. Information was gathered from the medical records of the patients and data were analyzed.Results: During two and half year’s period, the total number of deliveries was 2696 and the total numbers of stillbirths were 96, hence the stillbirth rate was 35.6/1000. 93 (96.87%) were antenatal stillbirths and 3 (3.12%) were intrapartum stillbirths. 82 (85.41%) women were unbooked. 85 (90.4%) belonged to low socioeconomic status. 67 (69.79%) were preterm. Maximum 39 (40.62%) belonged to 28-35 weeks of gestational age. The most common cause of Intrauterine death (IUD) was antepartum hemorrhage (17.7%). 14 (14.5%) were abruption and 3 were placenta previa. The second most common cause (14.5%) was the hypertensive disorder of pregnancy.Conclusions: The stillbirth rate in our institute is higher than the national average. The most common causes of IUD were antepartum hemorrhage, preeclampsia, prematurity, and malpresentation which can be diagnosed and managed by increasing uptake of antenatal care which will lead to timely identification and proper management of maternal and fetal complications eventually reducing the preventable stillbirths.
Prevalence, underlying factors and consequences of mobile game addiction in school going children of six to twelve years in Kanyakumari district
Authors: V. Arul Prasath S. , Perumal Bagavathy M. , Samuel Steeve Gnana
Published: March 2022

Background: Children nowadays are heavily engaged with their smartphones with high-quality gaming features. This addiction affects their health, causing physical and psychosocial disabilities. The objective of this study was to find the prevalence, underlying factors and consequences of mobile game addiction among school-going children.Methods: This cross-sectional study, conducted between 1st July to 31st December 2021, enrolled 120 children aged 6 to 12 years old attending the outpatient department of Kanyakumari Government medical college hospital.Results: We found out that male students displayed more addictive behaviour. The primary cause of mobile game addiction was loneliness, length of time spent playing mobile games and using it as their primary source of entertainment. This addiction resulted in headaches, eye and ear discomfort, insomnia, anxiety, depression, and disputes with family members.Conclusions: We found a correlation between video game addiction and psychosocial and physical disabilities. Extensive research is needed to identify gaming patterns leading to addictions and health consequences.
Clinical spectrum and outcome of elevated serum transaminases in tropical infections among children aged one month to 18 years in an urban tertiary care centre: a prospective observational study
Authors: Venkatesan Abhinaya , Bavanandam Sumathi , Sangaralingam Thangavelu , Krishnamoorthy Nedunchelian
Published: March 2022

Background: Tropical infections are common in our country and occur with a variable elevation of transaminases in a majority of them and they pose as a differential diagnosis to the viral infections affecting the liver including COVID-19 and complications like HLH and also paracetamol toxicity. Aim was to study the clinical profile and degree of elevation of liver enzymes in tropical infections in children aged one month to18 years.Methods: A prospective observational study of children from one month to 18 years of age with tropical infections in Mehta's multispeciality hospitals, Chennai, India between June 2017 and May 2019 was analyzed. Elevation of liver enzymes was categorized as mild (1-3 fold), moderate (3-20 fold) and severe (>20 fold).Results: Dengue was the most common infection in our study and the majority (49.07%), followed by enteric fever (78.06%), malaria (27.27%) and leptospirosis (25%), all had a mild elevation of SGOT. Severe elevation of SGOT was seen in 25% of leptospirosis and less than 10% in malaria and none with scrub typhus. SGPT elevation was severe in 50% of leptospirosis. Dengue shock syndrome had a severe elevation of transaminases.Conclusions: The most common infection was dengue and the majority had mild elevation and those with shock had a severe elevation of transaminases whereas shock was not a feature in leptospirosis even in severe elevation in our study. Though liver enzymes were very much elevated, children recovered without any residual liver damage.
Congenital macroglossia: case report of a rare disease
Authors: Srivastava Sandesh , Kumar Rahul , Sachdeva Money , Raj Richa , Singh Om P.
Published: March 2022

Macroglossia is a clinical disorder in which the tongue is larger than normal. Enlargement can be true as seen in vascular malformations or it could be due to muscular enlargement The prevalence of congenital macroglossia is less than 5 per 100,000 birth. Various causes include acromegaly, Beckwith-Wiedemann syndrome, congenital hypothyroidism, Down syndrome, and lymphangioma or haemangioma. It may cause significant symptoms in children such as sleep apnea, respiratory distress, drooling of saliva, difficulty in swallowing and dysarthria. Long-standing macroglossia leads to an anterior open bite deformity, increased incidence of upper respiratory tract infections and failure to thrive.
Effect of spironolactone with angiotensin receptor blocker on albuminuria in type 2 diabetic patients with nephropathy
Authors: Mahmud Hasan , Hai A. N. M. Abdul , Ahammod Tofael
Published: March 2022

Background: Diabetic nephropathy is the most important cause of the end-stage renal disease (ESRD). The aim of the study is to evaluate the effect of spironolactone 25 mg once daily in addition to losartan 50 mg once daily for 12 weeks for proteinuria reduction in diabetic nephropathy.Methods: This is a prospective clinical trial was carried out in the department of nephrology, national institute of kidney diseases and urology (NIKDU), Dhaka, Bangladesh from March 2015 to April 2016. A total of 60 patients attended the study considering inclusion and exclusion criteria. Proper ethical consent was taken from the relevant. Collected data were classified, edited, and analyzed into the computer for statistical analysis using SPSS version 22.Results: The mean serum creatinine baseline, end of 1st, 4th, 8th, and 12th weeks were significantly low (p<0.05) in the control group and significantly decline (p<0.05) in subsequent follow-up in both Intervention and control groups. The mean serum potassium- baseline, end of 1st, 4th, 8th, and 12weeks were not statistically significant (p>0.05) and significantly increased (p<0.05) in both groups. Improvement of urine albumin creatinine ratio was found 96.7% and 83.3% at end of 12th weeks in both groups respectively. It was observed that mean eGFR-baseline, end of 4th and 12th weeks were statistically significantly higher (p<0.05) in both groups with baseline.Conclusions: The addition of spironolactone 25 mg once daily with losartan potassium 50 mg daily for a 12-week period did not show a significant role in the reduction of proteinuria in diabetic nephropathy patients.
Potential risk factors for peripheral neuropathy in patients with type 2 diabetes mellitus: a case control study from central Rajasthan
Authors: Patel Govind R. , Samaria Anil , Kant Chandra , Prajapati Gopal R.
Published: March 2022

Background: Peripheral neuropathy is one of the most common and debilitating but preventable complications of diabetes mellitus, with significant morbidity as it often leads to foot ulceration and amputation. Therefore, this study was aimed to identify the potential risk factors for diabetic peripheral neuropathy (DPN) which can affect its progression.Methods: This case-control study was conducted on 240 patients with type 2 diabetes mellitus which included 120 patients with clinical evidence of DPN as cases and 120 patients without clinical evidence of DPN as controls. DPN was assessed clinically by neuropathic symptoms and neurological examination using 10 g 5.07 Semmes–Weinstein monofilament and vibration digital biothesiometer. Data regarding presence of potential risk factors were collected from all participants and analyzed using logistic regression analysis to measure an association with DPN.Results: A significant and independent association of advancing age, longer duration of diabetes, hyperglycemia, poor glycemic control, autonomic neuropathy and retinopathy with DPN (p<0.05) was observed. Hypertension, dyslipidemia, smoking, gender, body mass index, method of diabetes control and angiotensin converting enzyme inhibitor usage were not found be associated with DPN.Conclusions: Since hyperglycemia and poor glycemic control were only modifiable risk factors for DPN, intensive glycemic control and primary prevention are the cornerstones for reducing the incidence or slowing the progression of neuropathy and improving quality of life in diabetic patients.
Alcohol-induced hemiplegia hypoglycemia in end stage renal disease patient: a case report
Authors: Juliarta I Gede , Noverina I. G. A. Anggia
Published: March 2022

Hypoglycemia is one of the problems that often makes patients come to the emergency department. Generally, patients come with complaints of weakness, shaking, cold sweats, decreased consciousness. Hemiplegia is a rare clinical presentation in hypoglycemic patients. A case 44-year-old male comes to the emergency department with symptoms of weakness in the right half of the body and slurred speech noticed when he wakes up. History of drinking alcohol 1 day before. Based on history and physical examination, the patient is suspected of having stroke. Laboratory examination revealed that the patient had severe hypoglycemia. Administration of 50 ml of D40 fluid resulted in significant improvement in symptoms, and within 3 hours the neurological deficit disappeared. The head CT scan results were within normal limits. This case described hemiplegia which is a rare symptom of hypoglycemia, so that blood sugar checks are important in patients with suspected stroke.
Colchicine for pericarditis due to COVID-19: a case report
Authors: Patel Parth , Patel Sudhendu , Shah Vidhi
Published: March 2022

The pericardium is a fibroelastic sac made up of visceral and parietal layers separated by a (potential) space, the pericardial cavity.The most troublesome complication of acute pericarditis is the development of recurrent episodes of pericardial inflammation, occurring in 15% to 32% of cases. Therapeutic modalities are nonspecific and include non-steroidal anti-inflammatory drugs (NSAIDs) and corticosteroids. Here we present a case of a patient presenting with pericarditis due to COVID-19. He was successfully treated with colchicine. To our knowledge acute pericarditis due to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) might be an under diagnosed condition in this pandemic. We want to share our ﬁndings, given the urgent need for different diagnostic and therapeutic strategies in order to better manage COVID-19 patients, and diminish the SARS-CoV-2 complications.
Epidemiological profile of patients with urolithiasis in a tertiary care center of Eastern Nepal: a retrospective cross-sectional study
Authors: Lageju Nimesh , Neupane Durga , Kafle Awaj , Kumar Harsh
Published: March 2022

Background: This study is aimed to estimate descriptive statistics of socio-demographic and clinical profile of patients with urolithiasis visiting urology division, Department of Surgery of BPKIHS.Methods: This is a retrospective study. A total of 409 patients diagnosed with urolithiasis admitted to BPKIHS from January to December 2017 were included. The hospital medical records of patients were reviewed using a Pro forma to record the epidemiological data. The data was entered into the Microsoft Excel software and analyzed using statistical package for social studies (SPSS) software 23.0 version.Results: The peak age group of the high burden of urolithiasis observed was 20-30 years (27.1%) with the mean age plus standard deviation of the patients being 39.60±15.67 years. Among them, 54% were male and 46% were female with a ratio of 1.17:1. The most common site of urolithiasis was the ureter (44.1%) and kidney (39.3%). 11% of patients had stones on more than one site.Conclusions: It is concluded that the highest prevalence of urolithiasis is in the age group 20-30 years with male predominance and the common site being ureter. Further studies are needed as other factors affecting this disease are yet to be studied.