bluuebunny/crossref_metadata_2025 huggingface dataset:
Asimetrik Bilgi ve Firma Değeri İlişkisinde Finansal Kaldıracın Düzenleyici Rolü: BİST Üzerine Bir Uygulama
Authors: NUR Tuğba , Korkmaz Turhan
Published: July 2022

Çalışmada Borsa İstanbul (BİST) Gıda ve Perakende sektöründe işlem gören firmalarda asimetrik bilgi ile firma değeri ilişkisi ve asimetrik bilgi ile firma değeri ilişkisinde finansal kaldıracın düzenleyici rolünün olup olmadığının panel veri analizi yöntemi ile araştırılması amaçlanmıştır. Asimetrik bilgi değişkeni analistlerin tahminlerinin dağılımı, analistlerin tahmin hatası ve analistlerin pay başına getiri tahminlerinin dağılımın sektörün medyan tahmininden büyük veya küçük olmasına göre oluşturulan kukla değişken ile ölçülmüştür. Asimetrik bilginin firma değerine olan etkisinde finansal kaldıraç değişkeninin düzenleyici rolünün olup olmadığının araştırılması amacıyla asimetrik bilgi x finansal kaldıraç şeklinde moderatör (düzenleyici) değişkenler oluşturulmuştur. Haftalık veriler kullanılarak 10.06.2019-28.03.2022 dönemi için gerçekleştirilen analizler sonucunda asimetrik bilginin firma değerini negatif yönde etkilediği ve finansal kaldıracın bu etki üzerinde sınırlı bir düzenleyici rolü olduğu tespit edilmiştir. Çalışmada elde edilen bulgular mevcut ve potansiyel hissedarlar ve yöneticilerin alacakları kararlar açısından önemli olmakla birlikte, finansal kaldıracın asimetrik bilgi üzerinde düzenleyici rolünün sınırlı olmasının dikkate alınması gerektiği söylenebilir.
Kişiliğin, Gösterişçi Tüketimin ve İnternet Bağımlılığının Kompulsif Satın Alma Üzerindeki Etkisi
Authors: Terzi Onur , Bayrakdaroğlu Funda
Published: July 2022

Tüketim alışkanlıklarının sürekli değişmesi ve satın alma kararlarının rasyonellikten uzaklaşması, farklı tüketim tarzlarının ortaya çıkmasına neden olmaktadır. Kronik olarak tekrarlayan ve engellenemeyen bir satın alma dürtüsü sonucu ortaya çıkan kompulsif satın alma davranışı, bu farklı tüketim tarzlarından bir tanesidir. Bu çalışmanın ana amacı kişiliğin, gösterişçi tüketimin ve internet bağımlılığının kompulsif satın alma davranışı üzerindeki etkilerini incelemektir. İstanbul’da yaşayan 839 katılımcıdan anket yöntemiyle veri toplanmıştır. Yapısal eşitlik modeli kapsamında yapılan analizler neticesinde kişilik, gösterişçi tüketim ve internet bağımlılığının bireylerin kompulsif satın alma eğilimi üzerinde anlamlı etkilerinin olduğu görülmüştür. Kompulsif satın alma eğilimi ile dışadönüklük ve nevrotiklik kişilik tipleri ile arasında pozitif, deneyimlere açıklık kişilik tipi ile negatif yönlü bir ilişki tespit edilmiştir. Kontrol kaybı ve sosyal ilişkilerde olumsuzluk değişkenleri ile kompulsif satın alma eğilimi arasında da anlamlı ve pozitif yönlü bir ilişki olduğu belirlenmiştir. Ayrıca katılımcıların kompulsif satın alma eğilimlerinin yaş, cinsiyet, gelir düzeyi, eğitim durumu ve kullanılan kredi kartı sayısı gibi demografik değişkenler açısından farklılaştığı ortaya konulmuştur.
İşveren Markası Araştırmalarının Bibliyometrik Analizi
Authors: Kişi Nermin
Published: July 2022

Bu çalışmanın amacı, işveren markasına ilişkin bilimsel literatürün sistematik bir incelemesini sunmaktır. Bu amaca ulaşmak için Web of Science veri tabanından elde edilen işveren markası ile ilgili toplam 213 makaleden oluşan veri seti bibliyometrik analiz yöntemiyle incelenmiştir. Ülkeler, kurumlar, yazarlar, dergiler, atıflar ve anahtar kelimeler gibi bir dizi gösterge analize dahil edilmiştir. Bibliyometrik analizi görselleştirmek için VOSviewer yazılım programından yararlanılmıştır. Bulgular, işveren markası araştırmalarının yayın ve atıf sayısı açısından 2018 yılından itibaren genel bir artış eğilimi içinde olduğunu göstermektedir. Yayın sayısı açısından Hindistan, atıf sayısı açısından İngiltere lider konumdadır. En üretken kuruluş Hindistan’dan Hint Teknoloji Enstitüsü, en etkili kuruluş Belçika’dan Gent Üniversitesi’dir. İşveren markası daha çok yönetim ve işletme alanında çalışılan bir konudur. Çalışmalarda en sık kullanılan anahtar kelimeler işe alım, insan kaynakları yönetimi, çalışanları elde tutma, işveren çekiciliği ve çalışan adanmışlığıdır. Gelecekteki işveren markası çalışmalarının çeşitli insan kaynakları yönetimi işlevleri, çeşitlilik ve kapsayıcılık, kuşak farklılıkları ve teknoloji ile daha yakından ilişkilendirilmesi beklenmektedir. Sonuç olarak, bu çalışma işveren markası araştırmalarına kapsamlı bir bakış sağlamakta, araştırma alanının entelektüel haritasını oluşturmakta ve gelecekteki araştırmalar için bir yol haritası önermektedir.
PEMBELAJARAN BAHASA ARAB DI MADRASAH IBTIDAIYAH (TINJAUAN PADA KOMPETENSI GURU DAN MODEL PEMBELAJARAN)
Authors: Susiawati Iis , Zulkarnain Zulkarnain , Safitri Wiena , Mardani Dadan
Published: July 2022

This study aims to show that the competence of Arabic language teachers in choosing the right learning model can determine the success of the planned Arabic learning objectives. In this case, Arabic teachers need to continue to develop their competencies, which include language competence, cultural competence and communicative competence. The subjects of this study were Arabic teachers and grade 5 and 6 students of Madrasah Ibtidaiyah Al-Zaytun Gantar Indramayu. This study uses a qualitative descriptive approach and method. Data was collected by observation, interviews and documentation. The results of the study indicate that the competence of Arabic language teachers in Madrasah Ibtidaiyah still needs to be developed with various education and training programs for Arabic teachers to be able to improve the quality of Arabic learning based on adequate Arabic teacher competencies.
Prediction of the Strength Behaviour of the Sandy Soil by using Collapse Potential in the Kintele Site-Congo
Authors: Kempena Adolphe , Mbilou Gampio Urbain , Bissombolo Dhorjeanny , Goncalves Antonio Olimpio , Boudzoumou Florent
Published: July 2022

This work aims to evaluate the water effect on the soils collapse potential. The laboratory tests based on the soils samples preparation determined the soils properties. Parameters such as water content, dry unit weight, degree of saturation, voids ratio and particles size distribution were determined. The collapse potential was analysed indirectly according to various researchers criteria. The results confirmed the high vulnerability of the study area to collapse. The oedometer tests determined the values of the collapse potential showing the conventional relationship between the collapse potential and the water content. It is noted that increasing water content leads to decrease soils strength to collapse, and the increasing progress of collapse poses a risk to constructions on silty sand. The collapse potential decreases with the increase in the relative density keeping the water content constant. This collapse potential caused by soil water content variation can be reduced from compaction.
Service Performance Evaluation of ITS Library Institution Repository Website
Authors: Mursidah Eva , Wahyuni Davi , Gonti Yeni Anita , Raharjo Eko Budi
Published: July 2022

The ITS library as a unit that supports the ITS industrial revolution 4.0 strategy must make improvements to the application of information technology services to users. The ITS library repository website as a portal for storing scientific works of the ITS academic community is one of the information technology services that is often used by the ITS academic community (siva), but there has been no development for more than 5 years. For this reason, it is necessary to research evaluating the service quality of the ITS library repository website using webqual 4.0, which includes 3 (three) dimensions, namely: usability, information quality, and service interaction quality. The method used is a survey of distributing questionnaires to ITS final semester students who use the repository's independent upload service. As many as 100 students use the repository's independent upload service, then an IPA analysis (importance performance analysis) is carried out to determine the level of user satisfaction. The measurement results of the evaluation of the ITS Library repository website show a gap of -0.7, meaning that user satisfaction with the ITS Library repository website has not yet been achieved, while the IPA matrix diagram shows 2 (two) service indicators that are prioritized for quality improvement, namely interaction with the ITS repository website, which is safe from viruses and hackers when accessed via a PC or smartphone, and a quick search menu (title, author, supervisor, department) that gives inaccurate search results.
Business Cost Modelling of Information Processing in Supply Chain Units
Authors: Bucki Robert , Suchánek Petr
Published: July 2022

The paper analyzes and successively assesses the problem of information delays in a sample logistics system, in which customer inquiries are sent to adjacent or dedicated units in the logistics chain. Within such a framework time and unit costs of customer service and inquiry are analyzed. A detailed model of the logistics system is thus elaborated using a mathematical approach and its graphical representation. The accompanying case study includes the analysis of the detailed situation in which two models are compared that do not differ in the structure of logistic units but are characterized by different information flow paths. Simulation results are presented through a thorough graphic, numerical and descriptive analysis. Finally, the problem of information transmission in the logistics system is summarized.
Microbial biofilms in oenology
Authors: Gosset Marianne , Roques Christine , Taillandier Patricia
Published: July 2022

Biofilms are sessile microbial communities whose lifestyle confers specific properties. In recent years, they have attracted great interest in many research fields. Biofilms are indeed the cause of recurrent industrial problems, while microbial contaminations can finally impact the quality of a finished product or human health. However, these same properties can be interesting for several applications. Oenology is no exception, whether for potential damages to wine quality caused by biofilms or their beneficial effects through winemaking steps, from grape to bottle. This paper reviews yeast and bacterial biofilms in oenology, their nature, their negative effects, as well as the applications linked to their presence in wine and the mechanisms involved in their formation.
Massive Hydroxychloroquine Overdose in an Uncontrolled Diabetic Patient: A Case Report, Complications and Management
Authors: Vafadar Moradi Elnaz , Kamalodfini Mohammad Hossein , Khorashadizade Sanaz , Abbasifar Sara , Tabatabaeimehr Seyed Yasin , Salmani Izadi Hanieh , Zahedi Mohammad
Published: July 2022

Introduction Hydroxychloroquine (HCQ) is an antimalarial agent that has been tried out in the treatment of COVID-19, however, evidence of efficacy remains limited. Although Hydroxychloroquine overdose is not common, growing cases of poisoning with HCQ have been reported during recent years. HCQ toxicity is characterized by life-threatening symptoms which require immediate medical intervention. This report presents a suicide attempt in a hyperglycemic patient, massive ingestion of HCQ manifested by hypokalemia and acidosis.Case summaryA 47-year-old man presented at the hospital hours after massive ingestion of HCQ (100 tablets), with generalized weakness and dizziness which had led to a fall. He was drowsy and had experienced episodes of nausea/vomiting. His past medical history was remarkable for uncontrolled diabetes mellitus, confirmed by the blood glucose of 345 mg/dL, and a previous history of hospitalization a few months ago, due to a suicide attempt. He developed marked hypokalemia accompanied by acidosis, plasma potassium of 2.8 mmol/L and pH 7.34, and hypotension, blood pressure of 80/51 mm Hg, but survived with close cardiac monitoring and immediate intervention including aggressive potassium replacement, bicarbonate infusion, and charcoal administration. ConclusionConsidering the significantly increased off-label use of HCQ during the COVID-19 pandemic, this report alerts the potential for HCQ to be associated with severe electrolyte disorders, especially in predisposing conditions like diabetes. Clinicians should keep in mind the possibility of hypoglycemia in diabetic patients under hypoglycemic medications and concurrent use of chloroquine/HCQ. This therapeutic approach also suggests the benefit of even a delayed activated charcoal administration in the treatment of HCQ poisoning.
Asymmetry in Galaxy Spin Directions -- Analysis of Data from DES and Comparison to Four Other Sky Surveys
Authors: Shamir Lior
Published: July 2022

The paper shows an analysis of the large-scale distribution of galaxy spin directions of 739,286 galaxies imaged by DES. The distribution of the spin directions of the galaxies exhibits a large-scale dipole axis. Comparison of the location of the dipole axis to a similar analysis with data from SDSS, Pan-STARRS, and DESI Legacy Survey shows that all sky surveys exhibit dipole axes well within 1$\sigma$ error from each other. While non-random distribution is unexpected, the findings are consistent across all sky surveys, regardless of the telescope or whether the data were annotated manually or automatically. Possible errors that can lead to the observation are discussed. The paper also discusses previous studies showing opposite conclusions, and analyzes the decisions that led to these results. Although the observation is provocative, and further research will be required, the existing evidence justifies to consider the contention that galaxy spin directions as observed from Earth are not necessarily randomly distributed. Possible explanations can be related to mature cosmological theories, but also to the internal structure of galaxies.
Choose Wisely: Surgical Selection of Candidates for Outpatient Anterior Cervical Surgery Based on Early Complications Among Inpatients
Authors: Carlson Bayard C. , Dawson John M. , Beauchamp Eduardo C. , Mehbod Amir A. , Mueller Benjamin , Alcala Christopher , Mullaney Kevin J. , Perra Joseph H. , Pinto Manuel R. , Schwender James D. , Shafa Eiman , Transfeldt Ensor E. , Garvey Timothy A.
Published: July 2022

Background:

Anterior cervical discectomy and fusion (ACDF) and cervical disc arthroplasty (CDA) are attractive targets for transition to the outpatient setting. We assessed the prevalence of rapid responses and major complications in the inpatient setting following 1 or 2-level ACDFs and CDAs. We evaluated factors that may place patients at greater risk for a rapid response or a postoperative complication.

Methods:

This was an institutional review board-approved, retrospective cohort study of adults undergoing 1 or 2-level ACDF or CDA at 1 hospital over a 2-year period (2018 and 2019). Data on patient demographic characteristics, surgical procedures, and comorbidities were collected. Rapid response events were identified by hospital floor staff and involved acute changes in a patient’s clinical condition. Complications were events that were life-threatening, required an intervention, or led to delayed hospital discharge.

Results:

In this study, 1,040 patients were included: 888 underwent ACDF and 152 underwent CDA. Thirty-six patients (3.5%) experienced a rapid response event; 22% occurred >24 hours after extubation. Patients having a rapid response event had a significantly higher risk of developing a complication (risk ratio, 10; p < 0.01) and had a significantly longer hospital stay. Twenty-four patients (2.3%) experienced acute complications; 71% occurred >6 hours after extubation. Patients with a complication were older and more likely to be current or former smokers, have chronic obstructive pulmonary disease, have asthma, and have an American Society of Anesthesiologists (ASA) score of >2. The length of the surgical procedure was significantly longer in patients who developed a complication. All patients who developed dysphagia had a surgical procedure involving C4-C5 or more cephalad. Patients with a rapid response event or complication were more commonly undergoing revision surgical procedures.

Conclusions:

Rapid response and complications are uncommon following 1 or 2-level ACDFs or CDAs but portend a longer hospital stay and increased morbidity. Revision surgical procedures place patients at higher risk for rapid responses and complications. Additionally, older patients, patients with chronic obstructive pulmonary disease or asthma, patients who are current or former smokers, and patients who have an ASA score of ≥3 are at increased risk for postoperative complications.

Level of Evidence:

Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Environmental Effects of Sediment Release from Dams : Conceptual Model and Literature Review for the Kansas River Basin
Authors: Hernandez-Abram Darixa D. , Bailey Susan E. , McKay S. Kyle
Published: July 2022

Passing sediment from reservoirs to downstream channels is a potential solution to aging infrastructure and reservoir storage capacity loss, which is a pressing challenge nationwide. The US Army Corps of Engineers (USACE) sediment management actions at reservoirs such as flushing may drive ecological changes that may be beneficial or detrimental to downstream ecosystems. However, these potential effects are currently not well understood or documented. An exploratory study of the potential ecological effects of releasing sediment downstream from reservoirs is presented in this technical note (TN). We focus on Tuttle Creek Reservoir in Kansas and use fish species as indicators of ecological change. A literature review of Kansas fishes was conducted and three conceptual models illustrating potential benefits or negative effects of releasing sediment downstream of Tuttle Creek Reservoir was developed. Some fish species may benefit from sediment releases, while others may be negatively affected. Further research and tools are needed to develop a greater understanding of these effects.
FERN-ARTHROPOD INTERACTIONS FROM THE MODERN UPLAND SOUTHEAST ATLANTIC RAINFOREST REVEALS ARTHROPOD DAMAGE INSIGHTS TO FOSSIL PLANT-INSECT INTERACTIONS
Authors: CENCI ROMULO , HORODYSKI RODRIGO SCALISE
Published: July 2022

Ferns were among the first broadleaved plants in the fossil record. We assessed fern-arthropod interactions in modern ferns (Monilophyta) as a model for comparison with damage on ferns in the fossil record. We found that the functional feeding groups of margin feeding, hole feeding, surface feeding, piercing and sucking, oviposition, mining, and galling was present on 13 species of ferns at elevations ranging from 750 to 900 meters along mountain slopes of the Brazilian Atlantic Rainforest. We recognized 17 damage types (DTs), including one new DT, and provide implications for interpreting damage on leaves in the fossil record. Nine fossil DTs with modern analogues were found on ferns. Evaluation of damage on modern ferns demonstrate that the variation in the abundance and damage signatures of external feeding, piercing and sucking, galling, and mining enhances understanding of damage patterns on fossil leaves. The taphonomic implications to fossil plant-insect interactions are provided based on the sampling of modern arthropod damage and the preservation biases on ferns. Arthropod remains that are poorly attached to ferns, such as silk webs, eggs, and spider egg sacs, as well as insect exuviae, pupae, and body parts, might provide an important feature for arthropod preservation associated with fern leaves in the plant fossil record. This integrative method demonstrates that DT signatures on modern ferns indicate that ferns are an important host plant for herbivorous arthropods. Consequently, the same importance of ferns as host plants of arthropod herbivores likely was present in deep time.
Evaluating exercise limitation, gas exchange inefficiency and recurrence risk in PE patients by cardiopulmonary exercise testing
Authors: Zhu Hanqing , Zhu Wei , Sun Xingxing , Cao Yuan , Xu Jianhua , Pudasaini Bigyan , Yang Wenlan , Guo Jian
Published: July 2022

Background
Pulmonary embolism (PE) which is a form of venous thromboembolism (VTE) can induce acute symptoms and post-PE syndrome. Cardiopulmonary exercise testing (CPET) can evaluate exercise responses of multiple systems, including respiratory, cardiovascular, hematopoietic and skeletal muscle systems.
Methods
We retrospectively collected 103 subjects’ data of demographics, hematologics, CT pulmonary angiogram (CTPA), pulmonary function test (PFT) and CPET at Shanghai Pulmonary Hospital from March 2015 to October 2021. The 103 subjects were composed of 10 healthy people as control, 25 patients who had been diagnosed with PE and 68 patients who were diagnosed with PE. The CPET performance differences of the three groups of subjects and subgroups of PE patients divided according to CTPA were analyzed. Spearman correlation test was performed to analyze the correlation between CPET and Blood test parameters of the enrolled subjects. Univariate logistic regression analysis, multivariable cox regression analysis and Kaplan–Meier cumulative survival analysis was used to find CPET parameters for predicting the risk of PE recurrence.
Results
The exercise tolerance (load @ peak), metabolic capacity (VO2 @ AT, VO2 @ Peak), ventilatory efficiency (VE/VCO2 @ AT, VE/VCO2 @ Peak, OUEP, LOWEST VE/VCO2), gas exchange (PETCO2 @ AT, PETCO2 @ Peak, PETO2 @ AT), and cardiovascular response (VO2/HR) of healthy people, Post-PE and PE subjects were different. The ventilatory efficiency (VE/VO2, VE/VCO2, LOWEST VE/VCO2, OUPE, VE/VCO2 slope), gas exchange (PETO2, PETCO2) of PE subgroups divided according to CTPA were also different. VO2 @ AT (% pred) can be used to predict the risk of PE recurrence.
Conclusion
CPET is an effective and responsible method for the assessment of pulmonary embolism.
STOP? II trial: Cluster randomized clinical trial to test the implementation of a toolbox for structured communication in the operating room: Study protocol
Authors: Keller Sandra , Tschan Franziska , Semmer Norbert , Trelle Sven , Manser Tanja , Beldi Guido
Published: July 2022

BackgroundSurgical care, which is performed by intensely interacting multidisciplinary teams of surgeons, anesthetists and nurses remains associated with significant morbidity and mortality. Intraoperative communication has been shown to be associated with surgical outcomes, but tools ensuring efficient intraoperative communication are lacking.In a previous study, we developed the StOP?-protocol that fosters structured intraoperative communication. Before critical phases of the operation, the responsible surgeon initiates and leads one or several StOP?s. During a StOP?, the surgeon informs about the progress of the operation (Status), next steps and proximal goals (Objectives), possible problems (Problems), and encourages all team members to voice their observations and ask questions (?). In a before-after study performed mainly in visceral surgery, we found effects of the StOP?-protocol on mortality, length of hospital stay and reoperation. We intend to assess the impact of the StOP?-protocol in a cluster randomized trial, in a wider variety of surgical specialties (i.e. general, visceral, thoracic, vascular surgery, surgical urology, and gynecology).The primary hypothesis is that the consistent use of the StOP?-protocol by the main surgeon reduces patient mortality within 30 days after the operation. The secondary hypothesis is that the consistent use of the StOP?-protocol by the main surgeon reduces unplanned reoperations, length of hospital stay, and unplanned hospital readmissions.Methods: This study is designed as a multicenter, cluster-randomized parallel group trial. Board-certified surgeons of participating clinical departments will be randomized 1:1 to the StOP? intervention group or to the standard of care (control) group. The intervention group will undergo a training to use the StOP?-protocol and receive regular feedback on their compliance with the protocol. The surgeons in the control group will communicate as usual during their operations. The unit of observation will be operations performed by cluster surgeons. Consecutive patients will be enrolled over four months per cluster. A total of 400 surgeons will be recruited, and we expect to collect patient outcome data for 14’000 surgical procedures.Discussion: The StOP?-protocol was designed as a tool to structure communication during surgical procedures. Testing its effects on patient outcomes will contribute to implement evidenced-based interventions to reduce surgical complications.Trial registration: ClinicalTrials.gov; NCT05356962
Ergonomic Design and Modeling of Reconfigurable Wheelchair for Medical Purpose
Authors: Paytyan Tatevik Ashot , Melikyan Artashes Arsen , Zirakyan Srbuhi , Stepanyan Hovsep
Published: July 2022

As the design of various industrial items for the disabled is associated with a number of complications, requires a great deal of medical and constructive training, all the necessary standards have been studied. These standards relate to the ergonomic requirements of disabled people, the details of problems, as well as the technologies and opportunities needed in industry. The main types of existing wheelchairs are presented. Their advantages and disadvantages have been studied. Attention was also paid to the existing market in the given sphere, taking into account the possible market competition as a result of the project implementation. Due to the constructive, ergonomic-aesthetic study of the devices, a conceptual design of an innovative product in the given field was developed. The study and usage of all this gives an opportunity to make wheelchairs designed for the disabled, accessible to a wider range of people, as well as ergonomically comfortable, technologically innovative and competitive in the commercial market.
Clinical features and differences of Miller Fisher syndrome in southern China: Retrospective analysis of 72 patients from 13 provinces in southern China
Authors: Yu Hang , Ding Man , Chu Hong , Zhou Rumeng , Yao Jiajia , Fu Rong , Liu Yue , Xiao Zheman , Lu Zuneng
Published: July 2022

Objectives: We aimed to analyze the clinical features of Miller Fisher syndrome (MFS) in southern China and compare it features presenting in other countries. Methods: Medical records of patients with a diagnosis of Guillain-Barré syndrome (GBS) admitted to 31 tertiary hospitals, located in 13 provinces in southern China, from 1 January 2013 to 30 September 2016, were collected and retrospectively reviewed. Results: A total of 72 patients (36 from rural area and 36 from urban area) were enrolled. Their age at onset was 47.42±15.65 years old. Winter (29.2%) and spring (41.7%) were the seasons with the peak incidence of MFS. Thirty-eight (52.8%) patients had a history of upper respiratory tract infection one week before onset, while 4 (5.6%) patients experienced gastrointestinal infections. Among the 65 patients who underwent lumbar puncture, 48 (73.8%) patients exhibited albumincytologic dissociation in the cerebrospinal fluid study. Overall, 83.5% patients presented with limited outward movement of the eye, 64.2% had bilateral symmetrical ophthalmoplegia, and only 25.4% had unilateral ophthalmoplegia. No significant differences were observed between the rural and urban areas, such as age of onset (p=0.777) or sex distribution (p=0.609). Patients with complete ophthalmoplegia were older than those with incomplete ophthalmoplegia ( 64.53±7.69 years vs 43.19±14.40 years, p<0.001). Conclusion: Winter and spring are the peaks of MFS incidence. The incidence is higher in men than in women. The most common pattern of ophthalmoplegia in MFS is bilateral symmetrical ophthalmoplegia, There is no urban-rural difference in MFS in southern China. Patients with complete ophthalmoplegia were older than incomplete ophthalmoplegia. There is no significant difference of MFS between southern China and other East Asian countries.
Correlation of a guidewire maximum insertion length with tortuous radial artery and the success rate during transradial coronary angiography
Authors: Li Hongsong , Chen Xia , Sha Shuang , Xu Xiangdong , Chen Yingmin
Published: July 2022

Background
Percutaneous coronary intervention (PCI) is a safe and effective therapy for patients with obstructive coronary artery disease (CAD). We aimed to assess the correlation between the success rate of angiography and the maximum insertion length and resistance of a soft-tipped guidewire.
Methods
521 patients were treated by successful radial artery puncture. According to whether the guidewire resistance, the patients were divided to three groups. 17 patients were maximum insertion length of guidewire ≤ 30 cm when resistance was encountered (group 1). 17 patients were maximum insertion length of guidewire between 30 cm and 45 cm when resistance was encountered (group 2). 487 patients were no resistance encountered (group 3).
Results
The coronary angiography success rates of group 1, 2, and 3 were 52.94%, 47.05%, 98.97%, respectively. Typically, angiography can be completed in patients with Ω-shaped, S-shape or Z-shaped tortuosity.
Conclusions
The maximum insertion length of straight guidewire and resistance can be used to determine radial artery status. The radial artery tortuosity or spasm significantly affects the success rate of coronary angiography.
Slope stability analysis method of unsaturated soil slopes considering pore gas pressure caused by rainfall infiltration
Authors: Tian Wenjing , Peiffer Herman , Malengier Benny , Xue Song , Chen Zhongtian
Published: July 2022

The variation of pore gas pressure caused by rainfall infiltration is an important factor that leads to slope failures. The purpose of this study is to propose a new slope stability analysis method that considers pore gas pressure and examines the effect of airflow on slope stability by using a numerical method. A water-air two-phase flow analysis was conducted to investigate the distribution of pore air pressure, pore water pressure as well as water saturation triggered by rainfall infiltration. Then the variation of the load resulting from pore gas pressure was incorporated into the slope stability analysis method on the basis of the unsaturated soil shear strength theory and the residual thrust method to simulate the influence of airflow on the Tanjiahe landslide in China. In order to study the infiltration behavior with respect to initial saturation, water and gas flow analyses were performed considering various initial statuses of saturation under similar settings. Results showed that the pore gas pressure between the slope surface and slip band clearly varied and that it decreased during the process from the slide bed to the deep direction. Then the pore water pressure formed in the saturated zone was transferred by the airflow to the slope toe. As a result, because the pore gas pressure gradient increased the thrust of the slide mass, the safety factor decreased over time. Moreover, in the first step, the magnitude of infiltration decreased with an increase in initial saturation, while when the magnitude dropped to the minimum value, then it went up with an increase in the initial saturation. The maximum value was usually reached at a saturation degree of 0% or 100%. When evaluating slope stability, the safety factor obtained by the slope stability analysis method that considered the water-gas coupling effect was much lower than when it was not considered during the process of a similar seepage. Such impact on the slope failure was significant and may provide a practical reference for a hazard assessment to control rainfall-induced landslides.
Plasma level of ATPase inhibitory factor 1 (IF1) is associated with type 2 diabetes risk in humans: a prospective cohort study
Authors: Silva Julie Pires , Wargny Matthieu , Raffin Jeremy , Croyal Mikaël , Duparc Thibaut , Combes Guillaume , Genoux Annelise , Perret Bertrand , Vellas Bruno , Guyonnet Sophie , Thalamas Claire , Langin Dominique , Moro Cédric , Viguerie Nathalie , Rolland Yves , Barreto Philipe Souto , Cariou Bertrand , Martinez Laurent O.
Published: July 2022

Aim: Mitochondrial dysfunction is associated with the development of type 2 diabetes (T2D). It is thus of clinical relevance to identify plasma biomarkers of mitochondrial dysfunction associated with the risk of T2D.ATPase inhibitory factor 1 (IF1) endogenously inhibits mitochondrial ATP synthase activity. Here, we analyzed association of the plasma IF1 level with markers of glucose homeostasis and with the conversion to new-onset diabetes (NOD) in individuals with prediabetes.Methods: In the IT-DIAB prospective study, the baseline plasma level of IF1 was measured in 307 participants with prediabetes. The primary outcome was the incidence of NOD within five years of follow-up. Cross-sectional analysis of the IF1 level was also done in two independent interventional studies. Correlations between plasma IF1 and metabolic parameters at baseline were assessed by Spearman’s correlation coefficients, and the association with the risk of NOD was determined using Cox proportional‐hazards models.Results: In IT-DIAB, the mean IF1 plasma level was lower in participants who developed NOD than in those who did not (537 ± 248 versus 621 ± 313 ng/mL, p=0.01). The plasma IF1 level negatively correlated with clinical variables associated with obesity and insulin resistance, including the BMI (r = -0.20, p=0.0005) and HOMA-IR. (r = -0.37, p<0.0001). Conversely, IF1 was positively associated with plasma markers of cardiometabolic health, such as HDL-C (r = 0.63, p<0.0001) and apoA-I (r = 0.33, p<0.0001). These correlations were confirmed in cross-sectional analyses. In IT-DIAB, the IF1 level was significantly associated with a lower risk of T2D after adjustment for age, sex, and fasting plasma glucose (HR [95% CI] per 1 SD = 0.76 [0.62; 0.94], p=0.012).Conclusion: We identified for the first time the mitochondrial-related biomarker IF1 as being associated with the risk of T2D.
Observing the photo-induced structural dynamics of proton transfer in o-nitrophenol by Ultrafast Electron Diffraction
Authors: Nunes J. Pedro F. , Williams Monika , Yang Jie , Wolf Thomas , Rankine Conor , Parrish Robert , Moore Bryan , Wilkin Kyle , Shen Xiaozhe , Lin Ming-Fu , Hegazy Kareem , Li Renkai , Weathersby Stephen , Martinez Todd , Wang Xijie , Centurion Martin
Published: July 2022

Many important biological and chemical processes are initiated by the transfer of a proton from a donor to an acceptor group within a molecule and are regulated by the interplay of nuclear and electronic dynamics. The electronic dynamics of proton transfer are well-studied, yet the nuclear dynamics have never been spatiotemporally resolved. Herein, we present a direct observation of the nuclear motions leading to and ensuing from photochemical proton transfer in o-nitrophenol using ultrafast electron diffraction. The proton transfer step is identified by the transient compression of the donor-acceptor distance and captured on the femtosecond timescale with sub-Angstrom resolution. Supported by ab initio multiple spawning simulations, our observations uncover the structural changes mediating excited-state relaxation. Our work provides an unprecedented mechanistic insight into the photochemical proton transfer mechanism and photo-relaxation dynamics of o-nitrophenol, unambiguously connecting an experimental observable to a process previously confined to theoretical models.
Assessing the accessibility and utilization of maternal and child health information by adolescent girls during pregnancy in the Ohangwena Region, Namibia: A cross-sectional study
Authors: Shatilwe Joyce T. , Mashamba-Thompson Tivani P.
Published: July 2022

Background: High teenage pregnancy and poor maternal outcomes amongst young mothers and their offspring have been reported in Namibia. Access to maternal and child health information (MCHI) can improve maternal outcomes. However, the level of accessibility and the utilization of MCHI in Namibia is not known. The main objective of this study is to assess the accessibility and utilization of MCHI by adolescent girls during pregnancy in the Ohangwena Region of Namibia.Method: We conducted a cross-sectional study among pregnant adolescent girls attending clinic visits and healthcare workers in four different health centres in Ohangwena Region in Namibia. We collected data using a structured questionnaire. We employed SPSS version 25 for data analysis. A descriptive analysis was used to analyse the data. A cross-tabulation model and the Pearson Chi-square model were used to determine the p-value. A multivariate regression logistic model was used to determine the association between different variables. Result: Overall, 64% of the participants had started their antenatal care (ANC) late in their 2nd trimester (4-6 months). In this study, 25.5% of the participants traveled a distance of over 15 km to access healthcare facilities. Also, it revealed that there was limited information provided on the importance of family planning and the tetanus toxoid vaccination. The findings also show that a majority (62% to 82.6%) of the participants did not receive MCHI through either leaflet, brochures, video clips, or posters. Lack of knowledge on MCHI and socio-demographic factors such as travel distance to facilities, and economic, religious, and social issues further contributed to the identified challenges. Conclusion: The study findings such as distance to nearest health facilities contribute limited information on maternal healthcare being provided. More research studies are required to explore strategies that may assist adolescent girls to access MCHI. This, in turn, will increase the utilization of maternal healthcare services such as ANC.
Role of magnetic resonance imaging in the diagnosis of placenta accreta
Authors: NIU LEI , CUI WEN , ZHU CHUNXIA , WANG MINGHAO , LIU YUANYUAN , WANG YONGKANG , QIAO FENGLEI , YUAN YONGSHENG , LIU LONGMEI , WANG FENG
Published: July 2022

Objective. To analyze the value of magnetic resonance imaging (MRI) in suspicious cases for prenatal detection of placenta accreta(PA). Materials and Methods.A total of 50 placental MRI exams performed on a 1.5T scanner were retrospectively reviewed by two radiologists in consensus.HASTE (half-fourier acquisition single shot turbo spin echo)and True-FISP (true fast imaging with steady-state precession) sequences were acquired.Findings at MRI were compared with the final diagnosis,which werre determined with clinical findings at delivery and pathological examination of specimens. Results. Of 50 pregnant women in the analysis, 33 required cesarean hysterectomy, 17 underwent cesarean delivery. MRI signs such as myometrial thinning, loss of T2 hypointense interface(loss of retroplacental clear space on US), heterogenous intraplacental sign, and intraplacental T2 dark bands were more likely to be seen in this group. In this group, the cases that were finally clinically and pathologically confirmed were 12, 16 and 22 cases of placenta accreta vera, placenta increta and placenta percreta respectively. Conclusion. MRI is particularly useful in cases where US is inconclusive and to assess the extent to which the placenta penetrates the uterine serosa and invades outward into surrounding tissues. MRI has become a routine examination for patients with suspected PA in clinical practice.
WITHDRAWN: An efficient feature selection and classification approach for an intrusion detection system using optimal neural network
Authors: Pran S Gokul , Raja Sivakami
Published: July 2022

The intrusion detection system (IDS) has been developed as a robust method for investigating malicious activities by tracking suspicious attacks and triggering alerts. Intrusions and (or) risks, such as spoofing, traffic control, cyber-attacks, and other hazardous glitches breach the security principles of confidentiality, privacy, and accessibility, requiring the use of an IDS. It's more challenging to tell the difference between network traffic roles. It takes longer to tell the difference between natural and attacking behavior. To avoid this issue, an efficient feature selection and classification approach is proposed in this article for an intrusion detection system using optimal neural network. Before selecting the feature selection, the original data can be reduced with the help of a linear discriminant algorithm (LDA). The LDA algorithm is utilized to take less execution time for the whole detection system. After completing the reduction of the dataset, to choose features, the genetic particle swarm optimization technique (GPSO) is applied. It can manage linear and nonlinear based data, as well as redundant and unrelated features. Its efficiency is tested in the framework of IDS. The features selected by the proposed GPSO algorithm are used to construct an adaptive artificial neural network (AANN). AANN is utilized to identify normal activities and attacking activities. Moreover, the oppositional crow search algorithm (OCSA) is used for optimal designing of the attacking activities. Two well-known ID assessment datasets, like CICIDS 2017 and 2017-SUEE are used to test the success of the GPSO-AANN-OCSA-IDS methodology. The experimental results shows 98.83% and 99.64% accuracy based on the data set, such as CICIDS 2017 and 2017-SUEE for feature selection, and the classification accuracy is 98.14% and 97.96% respectively.
A new method for detection and classification of melanoma skin cancer using deep learning based transfer learning architecture models
Authors: Subramanian Balambigai , Muthusamy Suresh , Thangaraj Kokilavani , Panchal Hitesh , Kasirajan Elavarasi , Marimuthu Abarna , Ravi Abinaya
Published: July 2022

Melanoma is a kind of skin cancer that develops in melanocyte cells. It is one of the most serious kind of skin cancer, yet it is not as frequent as other types of skin cancer.It is very hard to detect, even under expert supervision. A Deep Convolutional Neural Network (D-CNN) Visual Geometry Group (VGG16) model, is proposed to improve the classification performance of skin lesions.The main disadvantage of using the deep learning methods is that more time is needed for training. Thus, with the help of transfer learning technique, the training time is reduced. The datasets utilized in the proposed strategy to train the model were obtained from International Skin Imaging Collaboration (ISIC).Metrics like Accuracy (ACC), Positive Predictive Value (PPV), Negative Predictive Value (NPV), Specificity (SPC), and Sensitivity (SE) were measured for the evaluation of the classification.The performance of the classification process done by the classifier model on a test data is represented using a confusion matrix. The proposed method of using transfer learning technique in Deep Convolutional Neural Network improved the accuracy of classification to 85% compared to 81% obtained from Convolutional Neural Network.
High Resolution 3D Shallow Crustal Structure of the Lembang Fault, West Java, Indonesia, produced with Ambient Noise Tomography
Authors: Syaifuddin Firman , Nugraha Andri D. , Zulfakriza Zulfakriza , Daryono Mudrik R. , Rosalia Shindy , Priyono Awali , Sahara David P , Widiyantoro Sri , Rasmid Rasmid , Supendi Pepen , Heryandoko Nova , Lesmana Aditya , Hidayat Wahyu , Rahayu Teguh , Librian Virga , Warnana Dwa D.
Published: July 2022

The Lembang Fault is located about eight km north of Bandung City, the capital city of the West Java province of Indonesia, with about 8.79 million people (dated 2020). Several studies state that the Lembang fault is an active fault with a maximum magnitude of 6.5 to 7. In terms of earthquake disaster mitigation, distinguishing characteristics of seismic velocity structures around active faults is critical. This manuscript presents our new research on ambient seismic noise tomography around the Lembang Fault by deploying 73 local temporary seismometer networks to develop a 3D high-resolution shear wave velocity model. We conducted a design acquisition analysis to obtain optimal results using a ray density analysis approach to image the geometry of the Lembang fault with good illumination and resolution, which is essential for identifying shallow geological features. Our result showed that variations in velocity values, both laterally and vertically, were related to variations in the volcanic rock on the near-surface. The geometry of the Lembang Fault and the existence of a low-velocity zone are well-identified from the seismic velocity structure, which low-velocity zone area has the potential for amplifying earthquake waves during an earthquake.
Evaluation of A22 Analogs as Gram-negative Antimicrobial Agents
Authors: Parhi Ajit K , Sun Yangsheng , Sagong Hye-Yeon , Rosado-Lugo Jesus , Datta Pratik , Zhang Yongzheng , Yuan Yi
Published: July 2022

S-(3,4-dichlorobenzyl) isothiourea (A22) and mecillinam are the only known antibacterial agents that act on the rod-shape maintenance mechanism of rod-like bacteria. This makes A22 an attractive lead compound for developing antibiotics with novel mechanism of action. In this study we expanded a limited structure activity relation (SAR) study previously reported and determined the effect of fused carbocyclic and heterocyclic analogs of A22 against three Gram-negative bacteria. Also, the efflux liabilities of the analogs generated here were examined in E. coli and P. aeruginosa.
A generalizable framework to comprehensively predict epigenome, chromatin organization, and transcriptome
Authors: Zhang Zhenhao , Qiu Yiyang , Feng Fan , Liu Jie
Published: July 2022

Many deep learning approaches have been proposed to connect DNA sequence, epigenetic profiles, chromatin organization, and transcription activity. While these approaches achieve satisfactory performance in predicting one modality from another, the learned representations are not generalizable across predictive tasks or across cell types. In this paper, we propose a deep learning approach named EPCOT which employs a pre-training and fine-tuning framework, and comprehensively predicts epigenome, chromatin organization, transcriptome, and enhancer activity in one framework, which is also generalizable to new cell/tissue types. EPCOT is the first framework proposed to connect all of these genome modalities and achieves superior predictive performance in individual modality prediction. EPCOT also maps from DNA sequence and chromatin accessibility profiles to vectors of generic representations which are generalizable across different modalities and characterize the connections among these modalities. Interpreting EPCOT model also allows us to provide a number of tools and services to the research community including mapping between different genomic modalities, identifying TF sequence binding patterns, and analyzing cell-type specific TF impacts to enhancer activity.