bluuebunny/crossref_metadata_2025 huggingface dataset:
Student Video Curation
Authors: Jones Matthew , Lawrence Snezana , Masterson Brendan , Megeney Alison , Sharples Nick
Published: March 2023

In the academic year 2020-21 Middlesex University maths students accessed all learning sessions remotely. Each of these interactive sessions was live-streamed, recorded and uploaded to our Virtual Learning Environment, providing hundreds of hours of recorded, unedited maths lecture for students to review.This case study reports on a project (partially funded by an IMA Education Grant) in which we invited undergraduates to reflect on their remote learning experiences and curate these video lectures. Students were asked to identify the most engaging, useful and interesting segments, and categorise and explain their choices in free-text comments to help us develop our approach to remote lectures and video resources.A total of 33 video clips were identified by students across levels 4 to 6 on our specialist BSc Mathematics and BSc Mathematics with Computing programmes. In this paper we will discuss our findings, illustrate with examples clips, identify themes in the student choices, and conclude with tips to produce engaging video content.We will also discuss applications of video curation as a social pedagogic tool for the current Generation Z students. We will argue that sharing how students interact with digital learning resources can help address the significant digital divide in education.
Editorial
Authors: Owen Alun
Published: March 2023

Editorial
Newly Acquired Data on the Geologic Structure and Hydrocarbon Potential in the Eastern Part of the East Siberian Sea Shelf
Authors: Zavarzina G.A. , Shapabaeva D.S. , Zakharova O.A.
Published: March 2023

—We report results of an integrated interpretation of geophysical data (2D CDP seismic acquisition and gravity and magnetic survey) conducted by Gazpromneft Science and Technology Center in the North Wrangel lease block on the East Siberian Sea shelf. The newly obtained geophysical data have allowed us to update the geological model of the sedimentary cover within the North Wrangel lease block, to clarify the limits of the Drem-Khed Trough, to reconstruct the conditions under which sedimentary complexes formed, and to identify possible promising oil and gas accumulation zones. We were able to determine the position of the main stratigraphic unconformities, to propose several approaches to their interpretation, and to identify the clinoform architecture of the Aptian–Albian and Cenozoic complexes within the Drem-Khed Trough. The integrated review of geological and geophysical data has been helpful in refining the framework of the main structures adjoining the trough and predicting the extent of potential reservoirs and oil and gas source rocks throughout the sedimentary cover. The Upper Cretaceous and Cenozoic complexes are regarded as oil and gas exploration targets.
Revisión narrativa de estudios por imágenes de las calcificaciones de la glándula submandibular
Authors: Rozas Pozo Marco , Fiori-Chíncaro Gustavo Adolfo , Llaguno-Rubio Jhoana Mercedes
Published: March 2023

La sialolitiasis es una de las patologías más comunes de las glándulas salivales mayores y se presenta con mayor frecuencia en las glándulas submandibulares. Entre el 80 y el 95% de los sialolitos se desarrollan en las glándulas submandibulares; entre el 5 y el 20%, en la glándula parótida; y solo el 1%, en la glándula sublingual. Los sialolitos se forman dentro del parénquima y los sistemas de conductos asociados. En el conducto de Wharton, del 80 al 90%, y solo el 15% en la glándula. La sialolitiasis es la causa del dolor e inflamación de la glándula salival al obstruir el conducto y evitar la secreción salival, antes, durante y después de la ingestión de los alimentos. El objetivo de esta revisión fue realizar la descripción actualizada de los distintos métodos de diagnóstico por imágenes, utilizados para el estudio de las calcificaciones de la glándula submandibular, a partir de diferentes estudios reportados en la literatura científica contemporánea, con la finalidad de establecer el diagnóstico correcto. Se realizó una búsqueda de la literatura en las principales fuentes de información, incluidas Medline (vía PubMed), Elsevier, SciELO y LILACS, usando los términos de búsqueda con una limitación de fecha de los últimos 5 años en promedio. Los artículos seleccionados incluyeron información referente a calcificaciones de las glándulas salivales. Los estudios por imágenes de las calcificaciones de las glándulas salivales se pueden obtener con radiografías convencionales, sialografía, ultrasonografía (US), tomografía computarizada (TC) y resonancia magnética (RM).
Chef a bordo
Authors:   , Céspedes Herrera Olenka Andrea , Cuadros Vargas Alessandra Giovanna , Leguía Cahuana Marjhory Jahayra , Maza Euribe Bryan Gabriel
Published: March 2023

“Chef a Bordo” incluye el servicio de chef que se brinda a domicilio a los clientes en ocasiones especiales del cliente para que puedan preocuparse por otros detalles de su evento especial y confiar plenamente en el servicio. Este proyecto se caracteriza por ser innovador y darle un nuevo trasfondo al servicio de chef a domicilio, brindar un precio razonable por una buena calidad en cuanto a los productos, asimismo existirá un servicio de maitre integrado para que el anfitrión de casa no se tome la molestia de servir los alimentos, que solo se preocupe por disfrutar su evento o velada en todo caso. Para que esto suceda de manera exitosa se dará por medio de un análisis interno y externo, que abarcó un estudio de mercado dándonos como indicador que los distritos de Santiago de Surco y Villa El Salvador son los más interesados por este servicio, además se diseñaron estrategias competitivas y comparativas para poder tener una participación en el mercado. Los objetivos que quieren lograr es posicionar la marca en la mente del consumidor para así llegar a ser una de las primeras opciones que solicite el cliente sin dudarlo, con la acogida lograda, se busca además, ampliar la gama de servicios ya que se ha identificado que existe interés en los servicios de clases de cocina personalizada y cocina virtual con una celebridad del mundo culinario. Existe una notable competencia pero “Chef a Bordo” se diferencia por generar un vínculo con su clientela y ofrecer un servicio impecable donde el anfitrión tenga la seguridad que todo saldrá a la perfección.
Saneamiento y riesgos ambientales microbiológicos en cuencas hidrológicas de Lima
Authors:   , Churano Shuan Daniel Jesús
Published: March 2023

En las últimas décadas, los países se han encaminado al desarrollo sostenible, y para ello se han planteado nuevas metas en búsqueda de la sostenibilidad y el bienestar social como el término de la pobreza y el acceso a salud, bienestar y saneamiento; para ello han creado normas que permitan alcanzar estos objetivos. Sin embargo, a pesar de ello, el marco normativo por sí solo no nos acerca al objetivo y mucho menos soluciona los problemas sociales y ambientales que implica la sostenibilidad; por lo tanto, se requiere de un análisis basado en la interacción de los componentes ambientales, sociales y económicos. Dentro de la realidad peruana la cantidad, distribución y calidad del agua es un problema preocupante, ya que puede amenazar a la salud y al ambiente. En cuanto a la distribución y cantidad, la problemática radica en la demografía nacional, esto debido a que la mayor parte de la población se ha asentado en zonas áridas. Respecto a la calidad, existen problemas graves causados por diferentes contaminantes, siendo unos los principales los microbiológicos por el limitado acceso a un adecuado saneamiento, especialmente en zonas pobres. Este factor de riesgo junto a otras malas prácticas; generan peligros ambientales microbiológicos con un alto potencial de riesgo. Para lidiar con este problema, una adecuada gestión que integre el saneamiento y recurso hídrico con enfoque a cuencas hidrológicas es muy importante, así mismo se requiere de evaluaciones de riesgos ambientales que estén sujetas a estándares de calidad ambiental aplicables a nuestra realidad. Estos son necesarios para preservar nuestro recurso hídrico y evitar pérdidas humanas y mejorar la salud ambiental.
Efecto del fertilizante orgánico no convencional de harina de cuernos y pezuña de ganado bovino en el rendimiento del Theobroma cacao L.
Authors:   , Zumaeta Barbarán Rodrigo Sebastian
Published: March 2023

El cacao (Theobroma cacao L.), debido a su potencial industrial y a los beneficios que genera su consumo en la salud del ser humano es apreciado en los mercados a nivel mundial. Producto de esto, los principales países cacaoteros destinan grandes extensiones de área para el desarrollo y aprovechamiento de esta planta, generando grandes volúmenes de producción. En ese sentido, el objetivo principal de esta investigación fue determinar el lento efecto fertilizante de la harina de cuerno y pezuña de ganado (HCP) en el rendimiento del cacao con la finalidad de validar y respaldar modelos de desarrollo orgánicos. Para este caso, se delimitó una parcela experimental en la estación de “Juan Bernito” perteneciente al Instituto de Cultivos Tropicales de Tarapoto, San Martin. Paralelamente, se realizó un análisis de las características químicas y físicas del suelo, el cual sirvió como base para establecer las dosis de fertilización de los cuatro tratamientos con HCP: 332.5 g planta-1 (T1), 249.9 g planta-1 (T2), 166.6 g planta-1 (T3) y 83.3 g planta-1 (T4), así mismo, se estableció un testigo sin nitrógeno (T0) y un tratamiento fertilizado completo (T5), el cual contemplo 72.5 g planta-1 de urea. Estos tratamientos contaron con cuatro repeticiones agrupadas en un bloque completo al azar. Se concluye que la HCP tiene un efecto significativo y similar al del fertilizante inorgánico de urea en el crecimiento del área de las hojas y en el contenido de clorofila; sin embargo, el mayor desarrollo de raíces laterales del cacao se dio con la HCP.
Estrés y depresión en el entorno académico - social en pandemia Covid-19 en estudiantes de Odontología durante el 2020
Authors:   , Espinoza Vilela Francis Valeria
Published: March 2023

Ante la pandemia del COVID-19 y la nueva modalidad de clases virtuales que atraviesan los estudiantes de odontología, puede traer efectos negativos en la salud psicológica y/o en el desempeño académico. El objetivo fue determinar la relación del estrés y depresión en el entorno académico social ante la pandemia del COVID-19 en los estudiantes de Odontología de la Universidad Científica del Sur. Materiales y Métodos: El estudio fue de tipo descriptivo observasional, transversal y prospectivo donde participaron 108 estudiantes de la carrera de Odontología de 6to a 10mo ciclo de la Universidad Científica del Sur y estos fueron evaluados mediante un cuestionario con la escala SISCO para medir el estrés académico y la escala BECK (IDB II) se utilizó para depresión. Resultados: El 100% de la muestra presenta estrés académico y depresión, donde se pudo apreciar que en el 6to ciclo existe mas probalidad de estrés y depresión; el grupo etario más afectado fueron los estudiantes de 19-22 años. El valor p para la relación entre el estrés académico y depresión fue p<0.001 Conclusión: Existe diferencias estadísticamente significativas entre el estrés académico y depresión en los estudiantes del 6to al 10mo ciclo de la carrera de Estomatología de la Universidad Científica del Sur.
Análisis comparado del ordenamiento jurídico entre Perú y Argentina, respecto al impacto de la aplicación del principio precautorio
Authors:   , Távara Arquínigo Narda Lilibeth
Published: March 2023

La presente investigación tiene por objeto ahondar en los pilares, los fundamentos del derecho ambiental que resultó ser altamente estudiado desde su concepción, toda vez que, para muchas personas dedicadas a estudiarlo, se trata de uno de los más controversiales al establecer que se deberán establecer políticas públicas y se deberá realizar esfuerzos para atenuar o prevenir los daños, que en ocasiones pueden ser definitivos, hacia el medio ambiente, aun cuando no existan consensos en la comunidad científica. Para ello, se llevará a cabo un estudio de nivel descriptivo y cualitativo, teniendo como procedimiento de análisis la comparación entre dos ordenamientos jurídicos, Perú y Argentina. Lo descrito conlleva a la exposición y análisis tanto normativo como de casuística que permita contrastar ambas realidades y apreciar con mayor claridad la efectividad que posee este principio en estos países latinoamericanos o si, de lo contrario, solo estamos cumpliendo con un estándar internacional al cual nos acogimos.
Centro de artesanía y cultura: los espacios de innovación artesanal para difundir el acervo cultural de Lurín, 2020
Authors:   , Llanos Cadenillas Milser , Jimenez Palma Angel Waldir
Published: March 2023

La presente tesis tiene como objetivo analizar, evaluar y determinar de qué manera los espacios de innovación artesanal permiten difundir el acervo cultural del distrito de Lurín, 2020. Ello permite el diseño de un equipamiento capaz de otorgar capacitación, investigación e innovación que involucre al proceso de producción de las líneas de artesanía en retablo, cerámica y textilería. La investigación tiene un enfoque mixto; es decir, cualitativo y cuantitativo, de tipo no experimental y correlacional. Se analizó 2 poblaciones, la primer referente a los pobladores de Lurín y la segunda los artesanos del mismo distrito. Para la primera población se elaboró una encuesta con la finalidad de conocer cuan allegados están a la artesanía local y a su difusión. La muestra fue de 267 personas y para la segunda población se elaboró una entrevista para conocer la difusión, diversidad y la producción su artesanía. Los resultados muestran que más del 80% tienen conocimientos sobre elaboración de artesanías de su propia cultura, se podría decir que algunos de los pobladores entre adultos y adultos mayores se han desarrollado como ebanistas, panaderos artesanales y tejedores, haciéndolos idóneos maestros artesanos, lo cual contribuiría con la difusión del acervo cultural. Además, se observa que el grupo de artesanos Ichimay Wari es reconocido por el 39% de los encuestados; ello evidencia la falta de difusión por parte distrito al no establecer eventos o difundir el potencial artesanal. Esto sustenta el proyecto diseñado, que busca impulsar el rol importante de la cultura, costumbres e identidad en el distrito de Lurín.
Propiedades psicométricas del inventario de ansiedad: rasgo - estado en adultos jóvenes
Authors:   , Olaechea Terán Déborah
Published: March 2023

La presente investigación tiene el objetivo de evaluar las propiedades psicométricas del Inventario de Ansiedad: Rasgo-Estado (IDARE) en adultos jóvenes de Lima Metropolitana. La muestra está conformada por 343 participantes, 32,2% hombres y 67,8% mujeres, de 19 a 30 años con una media de 22,37 años (DT=2,4). Dentro de los resultados se obtuvo la validez de consistencia interna mediante el análisis factorial que da como resultado división en 6 dimensiones válidas. Para la confiabilidad, se obtuvo un alfa de cronbach de 0,942, lo cual indica que el instrumento es confiable en el presente contexto. Se procedió a eliminar 1 ítem con baja confiabilidad, para obtener un alfa de cronbach de 0,944; lo que demuestra una alta confiabilidad. Finalmente, se realiza la baremación mediante el uso de percentiles creando así baremos generales, por sexo y por tipo de centro de estudio.
Relación entre la satisfacción laboral y la productividad de los colaboradores en el área de call center de la empresa Pizza Raúl, La Victoria, 2019
Authors:   , Medina Aguilar Sherley Carolina , Gutiérrez Vega Stefany
Published: March 2023

El fin del estudio fue determinar la relación existente entre la Satisfacción laboral y la Productividad de los colaboradores de call center de Pizza Raúl, La Victoria, 2019. Debe señalarse que se realizó con un enfoque cuantitativo, método hipotético–deductivo, de tipo básico, con un diseño no experimental, alcance correlacional y de corte transversal. La muestra fue censal conformado por 25 colaboradores de la empresa. Además, el instrumento utilizado para recolectar información fue un cuestionario con escala de Likert, establecido por 23 preguntas que fueron validadas mediante un Juicio de Expertos especializados por tres docentes de nuestra universidad. A fin de evaluar el nivel de correlación entre las variables en mención, se empleó el Rho de Spearman mediante el programa estadístico SPSS y se alcanzó un coeficiente de 0,833 con un Pvalor menor a 0,005; por lo tanto, la correlación es positiva muy fuerte. En conclusión, se confirma la dependencia directa entre la Satisfacción laboral y la Productividad de los colaboradores del call center de Pizza Raúl, La Victoria, 2019.
Desempeño docente y satisfacción académica de los estudiantes del I ciclo de la escuela de Economía, Universidad Nacional de Cajamarca - 2018
Authors:   , Fernández Rodríguez Edwin Horacio
Published: March 2023

La intención del presente estudio se fundamenta en establecer la existencia de una reciprocidad entre el desempeño como educador y la satisfacción estudiantil por el servicio de formación educativa que recibieron en el I ciclo de la Escuela de Economía de la Universidad Nacional de Cajamarca durante el año académico 2018. Para el desarrollo de la investigación de campo la población estuvo constituida por 420 alumnos y después de aplicar la fórmula estadística se determinó una muestra representativa integrada por 200 estudiantes de quienes se recopiló la principal información respecto a las variables involucradas en el estudio. La delineación de la investigación es de carácter no experimental, del tipo transversal y correlacional que posibilitó examinar las relaciones entre las dos variables, el instrumento de recojo de información fue el cuestionario que contó con la validación de expertos de igual modo se probó la confiabilidad del instrumento por medio de la estimación del coeficiente Alfa Cronbach. El valor resultante de dicho coeficiente es de 0,964 determinando para la presente tesis una alta confiabilidad de los instrumentos utilizados. El desempeño de la labor del profesor y su relación con la satisfacción por el servicio de formación recibido por el alumnos fue determinada mediante el cálculo del indicador de Rho de Spearman cuyo resultado 0.234 confirmó la presencia de una relación moderad entre dichas variables, cumpliendo de esta forma con los objetivos planteados y validando la hipótesis propuesta; en donde, también se corroboró que las dimensiones que conformaban la variable desempeño del docente como son: la especialización, el método didáctico y la destreza; mostraban una relación significativa con la variable satisfacción por el servicio de formación educativa en los alumnos.
Evidence-Based Policy Making: Insights and Policy Recommendations for the Implementation of a Clean Energy Transition in Kenya.
Authors: Fields Neve , Ryves David B , Yeganyan Rudolf , Cannone Carla , Tan Naomi , Howells Mark
Published: March 2023

With ambitious targets to drastically increase economic activity over the next decade in order to propel itself to become a middle-income country, Kenya’s future is undoubtedly energy intensive. Through the achievement of its bold and aspiring goals, Kenya is poised to become a regional economic giant with the capacity to strengthen its position as a global leader in renewable energy production. However, current energy capacity expansion plans will see Kenya drastically ramp up fossil fuel generation, significantly increasing emissions and regressing progress made towards its climate and renewable energy targets. Therefore, Kenya is at a crucial stage of its national development with critical decisions to make regarding its future energy expansion and production. The use of energy systems modelling as a method to provide key insights for evidence-based policy making has risen in importance in energy planning globally. Such an approach can provide crucial insights and projections on the impact of potential policy decisions, creating pathways to be adopted within policy. As a result, this study employs long-term energy systems modelling to explore a series of potential future scenarios for Kenya’s power sector, providing insights into their generation, total production, and costs that can assist national policy making. Specifically, this research utilises OSeMOSYS modelling software to produce a Clean Energy Transition scenario (CET) as one possible future for Kenya’s power sector to increase renewable energy production under rapidly intensifying demand. The critical insights gained in this research were employed to suggest seven key policy recommendations for Kenya’s power sector.
Transnational conservation to anticipate future plant shifts in Europe
Authors: Mendes Yohann Chauvier , Pollock Laura , Verburg Peter H. , Karger Dirk Nikolaus , Pellissier Loïc , Lavergne Sébastien , Zimmermann Niklaus , Thuiller Wilfried
Published: March 2023

To meet the COP15 biodiversity framework in Europe, one target is to protect 30% of land by 2030 through a resilient transnational conservation network 1,2. The European Alps are a key hub of this network hosting one of the most extensive natural areas and hotspots of plant biodiversity in Europe 3,4. Here, we assess the robustness of the conservation network to safeguard the European Alps’ flora by 2080 using semi-mechanistic simulations. Overall, we predict a shift in conservation need from lower to higher elevations through time as plants migrate upslope and shrink their distribution. While increasing species, trait, and evolutionary diversity, migration could also threaten 70% of the resident flora. Future expansions of the protected area network should ensure strong elevational connections, even those that span borders.
Mechanistic study of Huangqi Guizhi Wuwu decoction in the treatment of osteoarthritis using a weighted gene co-expression network and molecular docking techniques
Authors: Jiang Zhong bo , Cai Yu li , Wang Wei guo , Lv Wen xue
Published: March 2023

Objective: To use weighted gene co-expression network analysis (WGCNA) and molecular docking techniques to predict the mechanism of action of Huangqi Guizhi Wuwu decoction (HGWWD) in the treatment of osteoarthritis (OA) and to provide a bioinformatics basis for the clinical application of HGWWD in the treatment of OA.
Methods: After searching the Gene Expression Omnibus (GEO) database, the GSE55235, GSE206848 and GSE55457 datasets were obtained. After merging and normalizing the GSE55235 and GSE206848 datasets, differentially expressed genes (DEGs) were screened, modules closely associated with OA were screened using a weighted gene co-expression network (WGCN) constructed using R software, and the common genes among DEGs and key module genes were imported into the Database for Annotation, Visualization and Integrated Discovery (DAVID) for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. The active ingredients in HGWWD were retrieved through the traditional Chinese medicine systems pharmacology database and analysis platform (TCMSP), and a "drug-active ingredient-target" network was constructed using Cytoscape software. The GSE55457 dataset was used to verify and compare the expression differences in hub genes between different groups. AutoDock was used to conduct molecular docking of key genes and related active ingredients, and PyMOL and Discovery Studio were used for visual analyses.
Results: A total of 1455 DEGs were screened in the merged dataset, including 574 upregulated genes and 881 downregulated genes. The key module contained 388 genes. A total of 47 pathways were obtained from the KEGG analysis. β-Sitosterol, kaempferol, β-carotene, stigmasterol, and quercetin were identified as the main compounds of HGWWD, and interleukin (IL)-6, prostaglandin-endoperoxide synthase 2 (PTGS2), vascular endothelial growth factor A (VEGFA), JUN, MYC, NFKBIA, SELE, and chemokine (C-X-C motif) ligand 2 (CXCL2) were the main hub genes involved in the treatment of OA with HGWWD. Molecular docking indicated that except for quercetin, the binding energies of other major compounds to hub genes were less than -5.0 kcal/mol.
Conclusion: β-Sitosterol, kaempferol, β-carotene, stigmasterol and quercetin in HGWWD act on MYC, JUN, IL-6, VEGFA, and SELE, thus generating good therapeutic effects in individuals with OA.
Program Gate-Less Reconfigurable FETs Based on Ferroelectric
Authors: Lee Dong Hyeok , Chang Jiwon
Published: March 2023

In this work, we propose ferroelectric-based reconfigurable field-effect transistors (FeRFETs) which can switch the polarity without program gate (PG). In FeRFETs, the non-volatile and reconfigurable electrostatic doping by ferroelectric enables the type conversion without PG. Through the TCAD simulations calibrated with the experimental data, we confirm a reconfigurable high doping level (> 1×1021 cm-3), a clear type conversion and highly tunable performance in FeRFETs. It is also found that carefully tailoring coercive field (EC) is important to maximize the performance of FeRFETs.
Construction and evaluation of prognostic model of genes related to cell burial in idiopathic pulmonary fibrosis (IPF)
Authors: Sun YueFeng , Zhang YueYang , Wu Fan , Liu Xue
Published: March 2023

Background
Idiopathic pulmonary fibrosis (IPF) is a complex lung disease. Efferocytosis was related to IPF initiation and progression. The study aimed to mine efferocytosis-related genes (ECRGs) and establish corresponding prognostic signature in IPF.
Methods
Differentially expressed ECRGs (DEECRGs) were obtained by overlapping differentially expressed genes (DEGs) between IPF and normal samples and ECRGs. Univariate COX and the least absolute shrinkage and selection operator (LASSO) regression were applied to construct a risk model. The model was evaluated by Kaplan-Meier (K-M) and receiver operating characteristic (ROC) curves. Multivariate Cox model was performed, nomogram was further constructed. Moreover, gene set variation analysis (GSVA) and immune infiltration of two risk groups were explored. Last, the study evaluated the predictive power of EC-related model genes in both GSE70866 training dataset and GSE10667 validation dataset.
Results
A risk model was constructed with 5 ECRGs (CXCR4, ODC1, AXL, DOCK5 and MERTK). K-M analysis showed IPF patients in high risk group performed noteworthy poorer survival than those in low risk group. ROC curves indicated good performance of the risk model. GSVA illustrated that biological processes of diacyl bacterial lipopeptide and amino acid betaine biosynthetic process, and KEGG pathways of clycosaminoglycan biosynthesis chondroitin sulfate and butanoate metabolism signaling pathway were significantly different in two risk groups. Immune infiltration analysis showed that there were significant differential immune cells(Mast cells, naive B cells, actiated NK cells, M0 Macrophages, resting Dendritic cell and resting Mast cell)in two risk groups.
Conclusions
A risk model consisting of 5 ECRGs (CXCR4, ODC1, AXL, DOCK5 and MERTK) was successfully constructed, which could provide a new idea for the prognosis of IPF.
RETRACTED: Circulating hsa_circ_0008797 as a novel liquid biopsy biomarker for lung cancer diagnosis
Authors: Liang Nan , Zhang Luyi , Shao Zhuowei , Wu Yili , Chen Yu , Yang Yiming , Wu Shibo
Published: March 2023

The authors have requested that this preprint be removed from Research Square.
Human-Computer Interaction Facial Recognition in Music Teaching System Based on Parameter extraction algorithm
Authors: Huang Qian
Published: March 2023

Speech recognition technology becomes the focus of attention of major research institutions in the world. People hope that machines can understand human voice commands and that they can control machines with voice. Therefore, the research and development of voice recognition will make people's lives easier in the near future. The feature parameter selected in this paper is the Mel-Zepstr coefficient. It analyzes the MFCC parameter extraction process in detail and proposes an improved MFCC extraction algorithm. Compared with the traditional MFCC extraction algorithm, the calculation amount is reduced by nearly 50% and the feature is improved. With the increasing use of mobile robots in the service industry, technologies for human-computer interaction (such as face recognition) have attracted more and more attention. In order to meet the real-time and efficiency requirements of real robot platforms, and to improve the accuracy of feature extraction under various lighting conditions and facial recognition technology positions, this paper, facial recognition and feature tracking are analyzed. In setting the voice recognition and face recognition module function of human-computer interaction, this article will combination of traditional music teaching and related new technologies, the facial recognition and voice recognition, strengthen the function of music teaching system, in the traditional classroom teaching, homework management, music practice, on the basis of the information to inform, From two aspects of voice and face, to meet the music classroom online when the need for information function. It can not only enable music teachers to observe each student's expression and action through facial recognition, strengthen expression management, but also enable music teachers to analyze each student's musical expression, so as to provide more comprehensive guidance for students.
Olive oil and coconut oil improved the quality and digestibility of set soybean yoghurt
Authors: Cai Wen qi , Cao Shufang , Xia Mingjie , Zhang Guangchen , Huo Dafei , Yang Lina , Liu He
Published: March 2023

Most set soybean yoghurts have the problem of poor taste and flavor, and the overall quality is not as good as that of fermented milk. In order to improve the quality of set soybean yoghurt and to improve the flavor of set soybean yoghurt, a plant oil with pleasant flavor was added in the preparation of set soybean yoghurt. The effects of the addition of olive oil and coconut oil on the physicochemical quality, sensory quality, and nutritional quality of set soybean yoghurt, as well as the effects of fermentation and in vitro digestion on the distribution of oil in set soybean yoghurt, were investigated. Three kinds of set soybean yoghurt without oil, with coconut oil, and with olive oil were prepared. The results of GC–MS analysis showed that the set soybean yoghurt without oil contained only two esters and one alcohol: delta-dodecalactone, 5-decanolide, andR-(−)-2-butanol. The set soybean yoghurt with olive oil was characterized by five volatile flavors: hexanoic acid, 2-nonanol, phenylacetaldehyde, 3-heptylacrolein, and acetylpyrazine. The set soybean yoghurt with coconut oil was characterized by nine volatile flavors: 5-hydroxyoctanoic acid lactone, ethyl caprylate, ethyl caprate, ethyl laurate, 2-tridecanone, dihydro-2-methyl-3(2H)-thiophenone, lauric acid, 1-octanol, and 2-decanol. Gas chromatographic analysis showed that the set soybean yoghurt without added oil contained seven free fatty acids. The set soybean yoghurt with olive oil contained 10 kinds of free fatty acids and was high in oleic acid. The set soybean yoghurt with coconut oil contains nine kinds of fatty acids and is rich in lauric acid. By laser confocal microscopy observation, the oil droplets in the three groups of set soybean yoghurt were aggregated after fermentation, and the oil droplets in the three groups of set soybean yoghurt were reduced after digestion. Research has proved that adding an appropriate amount of olive oil or coconut oil to set soybean yoghurt can improve the taste and the flavor, and that the addition of oil does not increase the digestive burden.
Ancient, veteran and other listed trees as nest sites for wild honey bee, Apis mellifera, colonies
Authors: Visick Oliver David , Ratnieks Francis Leonard Waldemar
Published: March 2023

Implications for insect conservation: Our results show that ancient, veteran and other listed trees provide valuable nesting habitat for wild honey bee colonies in southeast England. Based on an occupancy rate of 2% and a recent estimate of 2 million TSIs in England, it is possible that TSIs support tens of thousands wild honey bee colonies across Britain and that wild colonies are a significant component of total colony numbers in areas with a high density of TSIs (>50 per km2). Wild honey bee (Apis mellifera) colonies naturally nest in old cavity-bearing trees throughout their range, but this important nesting habitat is in global decline. Here we determine the use of ancient, veteran and other listed trees as nest sites by wild honey bee colonies in Britain and investigate the effect of tree size, age, genus and management on occupancy. Over 1,000 trees of special interest (TSIs) were located in southeast England using the Ancient Tree Inventory (ATI) of the Woodland Trust, a charity that protects and promotes trees in Britain. 2% of all TSIs and 4% of TSIs with cavities were occupied by wild honey bee colonies (n=20). Occupancy positively correlated with tree diameter and nearest neighbour distance, suggesting that colonies are more common in large open-grown trees. Wild colonies occupied sweet chestnut (Castanea sativa) and maiden (unmanaged) trees more frequently than expected (7% and 2.7%, respectively, versus 2% overall). Sweet chestnuts have a large mean diameter (1.6m) and proportion of trees with cavities (73%), but these were no different from average in maiden trees (1.4m and 47%, respectively) and did not help explain occupancy.
Amorphous MOFs layer boosts the performance of metal anodes
Authors: Xiang Yang , Zhou liyuan , tan pingping , Dai Shuai , Wang Yannan , Bao Shu-Juan , Jiang Yinzhu , Lu Yingying , Xu Maowen , Zhang Xuan
Published: March 2023

Employing metal anodes can greatly increase volumetric/gravimetric energy density versus a conventional ion-insertion anode. However, metal anodes are plagued by dendrites, corrosion, and interfacial side reactions issues. Herein, a compact and flexible amorphous MOF layer was successfully synthesized and used as protective layer on metal anode aqueous zinc-ion battery (AZIB). Compared with the crystalline MOF layer, the unique amorphous MOF layer can inhibit dendrite growth at the grain boundary and eliminate ions migration near the grain boundary, showing high interfacial adhesion and large ion migration number (tZn2+ = 0.82). Besides, the amorphous MOF layer can effectively depress unfavored behaviors, e.g., corrosion of zinc anode, hydrogen evolution reaction, and dendrite growth on zinc surface. The prepared Zn anode with the amorphous MOF layer exhibited an ultra-long cycle life (ten months, 7000 h) and a low voltage (< 40 mV) at 1 mA cm-2 in a symmetrical cell. Even at 10 mA cm-2, it still showed a high stability for more than 5500 cycles (1200 h). The enhanced performance is realized for full cells paired with a MnO2 cathode. Besides, a flexible symmetrical battery with the Zn@A-ZIF-8 anode exhibited a good cyclability under different bending angle (0°, 90°, and 180°). Moreover, various metal substrates were successfully coated with compact A-ZIF-8. The A-ZIF-8 layer can obviously improve the stability metal anodes, including Zn, Mg and Al. The results not only demonstrate the high potential of amorphous MOFs decorated Zn anodes for AZIBs, but also propose a new family of protective layers for metal anodes.
A Self-Assessment on Online Learning Efficiency by Medical Students in a Chinese Medical University during the Early Phase of the COVID-19 Outbreak
Authors: Shen Ying , Yang Danqing , Ma Jiaqi , Huang Minting , Lan Yumei , Fan Shujing , Zuo Yanli
Published: March 2023

Background
At the initial stage of COVID-19 outbreak, most medical education institutions in China had to accept the sudden shift from classroom teaching to nearly 100% online instruction for different curricula. However, little has been known about medical students’ learning efficiency when learning has been completely conducted online. This study aimed at investigating medical students’ perspectives on online learning efficiency during the early phase of the COVID-19 outbreak and finding possible factors that could damage online learning efficiency.
Methods
Between May and July, 2020, the authors electronically distributed a self-designed questionnaire to all the 780 medical students who attended the Rural-oriented Free Tuition Medical Education program in Guangxi Medical University that locates in the southwestern China. Data on participant demographics, learning phases, academic performance, and perceptions regarding learning efficiency of online and classroom learning were collected. Wilcoxon rank sum test, Kruskal Wallis test, and polynomial Logistic regression were employed to detect differences of learning efficiency between online and classroom learning, and associations among learning phases, academic performance and online learning efficiency.
Results
A total of 612 medical students validly responded to this survey (valid response rate 78.46%), and they reported more positive perceptions of efficiency in the circumstance of face-to-face learning than of online learning despite of gender (P<0.001), learning phases (P<0.01), and academic performance (P<0.01). Learning phases and academic performance positively corelated with online learning efficiency (P<0.01). In responders’ opinion, the five top factors that most damaged online learning efficiency were low academic motivation, poor course design, inferiority in online teaching ability, limited interactions between faculty and students or among students, and insufficient learner engagement.
Conclusion
This study indicates obviously negative impact brought by pure online learning on perceived learning efficiency of medical students, and positive associations amid learning phases, academic performance, and online learning efficiency. We advise that instead of pure online instruction, more effort should be put into developing new online course design to improve learning efficiency when online instruction is conducted in large scale, and learning phase and academic performance should be taken into account for effective implementation of online learning.
Amyloid-Eszett (Aß), a false positive of amyloid-beta (Aβ), in the neurodegenerative disease literature: A bibliometric assessment
Authors: Nazarovets Serhii , Silva Jaime A. Teixeira da
Published: March 2023

One of the most prominent neurodegenerative diseases is Alzheimer’s disease (AD), one cause of which is the extracellular aggregation of amyloid-beta (Aβ). Some literature related to AD has represented the Greek letter β with the German letter Eszett (ß), resulting in the formation of a non-existent compound, amyloid-Eszett(Aß). This study aimed to quantify the AD-related literature in the Web of Science Core Collection carrying a mention of this false positive. A search on November 22, 2022 revealed 134 results. The highest incidence of false positives per year was observed in 2012 (41 cases). The journal with the highest incidence of amyloid-ß was the Journal of Neurochemistry (nine times), most cases (58) were found in Wiley journals, while authors with a US affiliation accounted for most (38) false positives. A Scopus search on the same date revealed 327 false positives, highest in 2020 (50 cases), most in Journal of Alzheimer's Disease (34 times), and most frequently by corresponding authors with a US affiliation (92 times). This erroneous substitution of a Greek letter (in Aβ) by a German one (Aß), despite giving a non-existent compound, will likely not change the underlying scientific conclusions of the affected papers, although errata might be useful to enlighten others, including metadata managers and journal copyeditors, so as not to repeat the same mistake.
Impact of translation on biomedical information extraction from real-life clinical notes
Authors: Gérardin Christel , Xiong Yuhan , Wajsbürt Perceval , Carrat Fabrice , Tannier Xavier
Published: March 2023

The objective of our study is to determine whether using English tools to extract and normalize French medical concepts on translations provides comparable performance to French models trained on a set of annotated French clinical notes.
We compare two methods: a method involving French language models and a method involving English language models. For the native French method, the Named Entity Recognition (NER) and normalization steps are performed separately. For the translated English method, after the firsttranslation step, we compare a two-step method and a terminology- oriented method that performs extraction and normalization at the same time. We used French, English and bilingual annotated datasets to evaluate all steps (NER, normalization and translation) of our algorithms.
Concerning the results, the native French method performs better than the translated English one with a global f1 score of 0.51 [0.47;0.55] against 0.39 [0.34;0.44] and 0.38 [0.36;0.40] for the two English methods tested.
In conclusion, despite the recent improvement of the translation models, there is a signifi- cant performance difference between the two approaches in favor of the native French method which is more efficient on French medical texts, even with few annotated documents.
Coherence based automatic short answer scoring using sentence Embedding
Authors: DADI RAMESH , Sanampudi Suresh Kumar
Published: March 2023

Automatic essay scoring is an essential educational application in natural language processing (NLP). This automated process will alleviate the burden and increase the reliability and consistency of the assessment. With the advance in text embedding libraries and neural network models, AES systems achieved good results in terms of accuracy. However, the actual goals are not attained, like embedding essays into vectors with cohesion and coherence, and providing feedback to students is still challenging. In this paper, we proposed coherence-based embedding of an essay into vectors using sentence-BERT (Bidirectional Encoder Representations from Transformers). We trained these vectors on Long Short-Term Memory (LSTM) and Bi-LSTM (Bidirectional Long Short-Term Memory) to capture sentence connectivity with other sentences' semantics. We used two different datasets; one is standard ASAP Kaggle, and another is a domain-specific dataset with almost 2500 responses from 650 students. Our model performed well on both datasets, with an average QWK (Quadratic Weighted Kappa ) score of 0.76. Furthermore, we achieved good results compared to other prescribed models, and we also tested our model on adversarial responses of both datasets and observed decent outcomes.
Development of an index predicts the in-patient mortality of COVID-19 patients presenting at a hospital in rural Michigan.
Authors: Varriano Brenda , Bhagat Yuvraj , Lepley Thomas , Sassine Antoine , Zikos Dimitrios , Ragina Neli , Megaly Maher , Tan Jaime , Haddad Nicholas
Published: March 2023

Background
Laboratory test results and chief complaints (CC) for patients hospitalized with COVID-19 can contribute to a better understanding of inpatient mortality risk. This study used a combination of lab test results on admission, demographic information, comorbidity data, and reported patient chief complaints to create a predictive model for inpatient mortality from COVID-19.
Methods
Clinical data were collected from a regional hospital (MI, USA). 1,093 COVID-19 patients were admitted. The CC, lab variables, and health comorbidities were inserted into a multiple binary logistic regression model alongside comorbidity information and the lab results, which was used to create a risk estimation tool for inpatient mortality in patients hospitalized with COVID-19.
Results
1,088 cases were included in the analysis. 23.25% of the hospitalized COVID-19 patients (N = 253) died. The average age of patients who died was 77.14 years (+/- 13.99) vs 64.22 years (+/- 18.35) for those who did not die. 49.9% (N = 545) of patients were female. Mortality was higher in non-white patients [OR = 3.7 (95% CI: 1.14–12.1)], those older in age [OR = 1.1 (95% CI: 1.04–1.14)]; those with a prior myocardial infarction/coronary artery disease [OR = 2.7 (95% CI: 1.02–7.03)], those with hypertension [OR = 5.2 (95% CI: 1.14–12.1)] and those with higher WBC counts [OR = 1.2 (95% CI = 1.02–1.50)]. High total protein indicated decreased mortality [OR = 0.4 (95% CI = 0.20–0.84)].
Conclusions
Multiple comorbidities are associated with greater mortality in those hospitalized with COVID-19. Understanding these risks will aid clinicians and healthcare systems in decision-making and allocation of resources to control disease burden.
Knowledge, Attitudes and Associated Factors of pre-hospital care Among Health Care Workers in Three Selected pre hospital care Center in Addis Ababa, Ethiopia, 2022
Authors: Koster Yohannes , Silesh Alemayehu
Published: March 2023

Back Ground:Pre-hospital care is an emergency medical care which is given to patients before arrival in hospital after activation of emergency medical services which is acknowledged as a crucial period, when irreversible pathology and secondary injury can be prevented. The aim of EMS focuses on providing timely care to victims of sudden and life-threatening injuries or emergencies in order to prevent needless mortality or long-term morbidity.Objective:To assessKnowledge, Attitudes and Associated Factors of pre-hospital care Among Health Care Workers in Three Selected pre hospital care Center in Addis Ababa, Ethiopia, 2022.Methods:institutional based cross sectional study design was conducted among HCW. The target population was HCW working at the pre-hospital care at three selected center Addis Ababa. The researcher was used questionnaire which is adopted from previous similar study. A questionnaire was distributed to consenting HCW for completion. Data was checked, cleared and entered in to SPSS version 25, then frequencies, distribution, mean computed and analysis were done to obtain the significant association by p=.25 at bivariate level then executed to multivariate logistic regression at p value 0.05.Result:One hundred thirty five study participants were included in this study with a response rate of 96.4%. The mean ages of the respondents were 29.2 years (SD ± 4.86). Almost three fourth of the study participants 96(71.1%) were in age between 26 and 35 years. Majority of the study participants 126(93.3%) responds that they knew about basic life support/advanced life support. 79(58.5 %) of the health care workers had good knowledge and 56(41.5%) had poor knowledge about pre-hospital care.Conclusion and recommendation:More than half of (58.5 %) of the health care workers had good knowledge about pre-hospital care and more than a half, eighty four (62.2%) had positive attitude towards pre-hospital care. Profession, educational status and training were significantly associated with knowledge of health care workers to wards pre-hospital care with p-value less than 0.05. Knowledge of the respondent and getting training were significantly associated attitude of health care workers towards pre-hospital care with p-value less than 0.05
Green synthesized Ag/rGO embedded flexible cotton SERS substrate for detection of methylene blue
Authors: Gokulakrishnan J , Sekhar K. C. , Koppole Kamakshi
Published: March 2023

Ag/rGO nanocomposite SERS substrates are widely used for the detection of contaminations in water and food adulterants. In this work, we prosed a novel green route to synthesize Ag/rGO nanocomposite for SERS-based detection of methylene blue (MB). Ag/rGO nanocomposite is synthesized by simultaneous reduction of AgNO3 and GO with the leaf extract of Jasmine fluminense. Further, the flexible SERS substrate is fabricated by directly coating the synthesized Ag/rGO nanocomposite on cotton fabric and used for SERS-based detection of MB. The SERS studies on MB show a linear response of 0.97 over a wide detection range of 10− 3 to 10− 9 M with a minimum detection limit of 10− 9 M. The enhancement factor for MB at a concentration of 10− 9 M is 5.33 × 105 with a high signal-to-noise ratio of 31.69. This study emphasizes the potential of green synthesized Ag/rGO embedded flexible cotton SERS substrate for the traceable fingerprint detection of MB.