bluuebunny/crossref_metadata_2025 huggingface dataset:
The Meaning of Welcoming Dance in Ijab Qabul Procession in Talang Bunut Village, Amen Sub-District Lebong Regency Bengkulu Provision
Authors: Aninda Nissafitri  , Darmawati
Published: April 2024

The purpose of this study is to describe the Meaning of Welcoming Dance at the Ijab Qabul Procession in Talang Bunut Village, Amen District, Lebong Regency, Bengkulu Province. This type of research is qualitative research with descriptive methods. The researcher's own research instruments and assisted by supporting instruments in the form of writing, cameras or mobile phones, and flash drives. Data collection techniques are carried out through literature studies, observations, interviews, and documentation. The steps in analyzing data include data reduction, data presentation, and conclusions. The results revealed that the Welcoming dance in the ijab qabul procession has the meaning of maintaining the security of the bride and the location of the event from all forms of unwanted disturbances. Textually, the meaning of the Welcome Dance, namely: (1) Preparation movements as a form of readiness to welcome guests. (2) The motion of starting to dance shows the dancer starting to greet guests. (3) The motion of presenting betel as a symbol of the custom of welcoming guests. (4) The gesture of giving a shawl means that the groom has been well received by the bride's family. (5) The motion to pave the way means that the bride's family has received the groom's goodwill. (6) Return to position means ensuring the event location is safe. (7) The gesture of sitting as a salute to welcome guests. (8) The gesture of giving way means giving way to the groom to carry out his good intentions. (9) Jang Pat Petulai silat movement means ensuring the security of the event location. (10) Sowing motion.
Implementation of Student Dance Self-Development at SMP Negeri 7 Padang
Authors: Anjelina Utari  , Marzam
Published: April 2024

The purpose of this study is to learn more about and describe how dance self-development is being implemented at SMP Negeri 7 Padang. It uses a descriptive method with a qualitative research approach. The researcher serves as the main data collecting tool, assisted by equipment like cameras and office supplies. In this study, both primary and secondary data were gathered through observation, interviews, documentation, and a review of the literature. Data collection, data reduction, data presentation, and conclusion-making are all parts of the data analysis process. The results show that SMP Negeri 7 Padang's approach for dance self-development activities is well-coordinated, adhering to the plans and programs specified by the supervisor. This coordination aligns with the goals of the program and takes into account elements like timing and scheduling. Dance self-development activities have been successfully carried out at SMP Negeri 7 Padang, with students making every effort to stick to the schedule and the allocated location. Nevertheless, there have been issues with insufficient infrastructure and facilities. Every month, notably on Wednesdays from 7:00 AM to 07:40 AM, routine performances presented as part of the dancing self-development activities take place. Students can use these performances as a platform to demonstrate how their exercises have progressed and to build their self-confidence when performing in front of an audience.
YOLOv5 untuk Menghitung Sel Darah Merah dan Sel Darah Putih
Authors: Benarkah Njoto , Naufal Mohammad Farid , Renatasiva Billy
Published: April 2024

Health practitioners use hemocytometer to manually counting the blood cells, and it is considered time-consuming, arduous, and expert-dependent. Automated methods are costly, require meticulous maintenance, can lead to misidentify abnormal cells. This research proposed an application that swiftly, precisely, and easily count red and white blood cells. YOLOv5 is used to detect red and white blood cells in digital images. The model is trained on BCCD dataset and BCCD+ALL-IDB1 using YOLOv5s configuration and 736x736 image input size, and achieve 89.9% mAP50 value for red blood cell counting using BCCD dataset. About 17.7% mean absolute percentage error (MAPE) is obtained using YOLO5x configuration with 416x416 image input size tested on BCCD dataset. The YOLOv5s configuration setup with 736x736 image input size gives 10.9% error rate against ALL-IDB1 dataset. The system is developed using Laravel and Flask, and it proficiently detects and counts red and white blood cells.
The Effect of Asset Valuation Method, Auditor Quality, Characteristics of the Board Commissioners and Audit Committee on Stock price Synchronicity
Authors: Putri Arrin Insani
Published: April 2024

Stock price synchronicity refers to the extent to which firm-specific information is absorbed in stock prices relative to market-wide information. If return variations are more synchronized with market information, then stock price synchronicity decreases which is indicating lower quality of financial reports. This research examines the effect of asset valuation methods, auditor quality, characteristics of the Board of Commissioners and the Audit Committee on the synchronicity of stock price of manufacturing companies listed on the Indonesia Stock Exchange in 2020-2022. A total of 490 observations were available for hypothesis testing. The results show that the quality of the auditor and the size of the Board of Commissioners have negative effects on stock price synchronicity. On the other hand, the asset valuation method, the independence of the Board of Commissioners and the Audit Committee have no effect on stock price synchronicity of. The practical contribution of this research is that companies need to consider hiring more commissioners and Big Four accounting firms to increase the credibility of financial reports.
A Case Study of Gas-Condensate Reservoir Performance with Gas Cycling
Authors: Udovchenko Oleksii , Blicharski Jacek , Matiishyn Liliia
Published: April 2024

The study examines the application of dry gas injection technology (cycling process) in different depletion stages (25%, 50%, 75%, 100% of the initial reservoir pressure, and the dew point pressure) at a gas condensate field. The injection took place with varying numbers of injection wells relative to production wells (4:1, 3:1, 2:1, 1:1, and 1:2). The study assessed the impact of dry gas injection periods, ranging from 1 to 3 years, on increasing the condensate recovery factor in a real gas condensate reservoir named X. A hydrodynamic model was used and calibrated with historical data, resulting in a comprehensive approach. Compared to the traditional depletion development method, this approach led to a significant 9% rise in the condensate recovery factor. The results indicate that injection has a positive effect on enhancing the recovery factor of condensate and gas when compared to primary development methods based on depletion. As a result, these findings facilitate a rapid evaluation of the possibility of introducing similar measures in gas-condensate reservoirs in the future for reservoir systems that have a low and moderate potential for liquid hydrocarbons C5+. The optimised multidimensional hydrodynamic calculations, utilising geological and technological models, are crucial in determining the parameters for the technological production and injection wells.
Delineation of Groundwater Potential Zones for Sustainable Development and Planning using AHP and GIS Techniques in the Coal Mining Province of Mahan River Catchment Area
Authors: Kausher Rukaiya , Kumar Sinha Anand , Singh Rambabu
Published: April 2024

The present research aims to address the drinking water crisis in the Mahan River catchment area resulting from the disruption of groundwater availability due to extensive coal mining. The study uses GIS-based Multi-Criteria Decision Analysis (MCDA) to map the groundwater potential of the area by analysing several factors that affect groundwater availability, including rainfall, water depth, geomorphology, geology, soil, land-cover/land-use, and topographic characteristics derived from DEM. The groundwater potential map created using the MCDA technique classified the area into low, moderate, and high groundwater potential zones. The map was validated and verified using water table depth and electrical conductivity values available in the region, indicating that it can be used to identify groundwater recharging sites. The study’s results show that about 30% of the area has high groundwater potential, and more than 45% of the area has moderate groundwater potential. The information derived from the study can be used for sustainable management and proper planning of groundwater resources in the Mahan River catchment area. Overall, the study presents a useful approach to address the groundwater depletion problem resulting from coal mining activities in the Mahan River catchment area.
An Analysis of the Methane Explosion in the Area of the Return Shaft Bottom at Mine
Authors: Wasilewski Stanisław , Szlązak Nikodem , Jamróz Paweł
Published: April 2024

Methane explosions are one of the greatest hazards in the coal mining industry and have caused many accidents. On 27 July 2016 at approximately 11:01 a.m., an explosion of methane occurred at the bottom of Zygmunt return shaft at the depth of 411 metres. The explosion resulted in one casualty. The article presents the results of, and the conclusions from, an in-depth analysis of the changes in the parameters of mine air, especially methane concentration, air flow and the operation of mine fans, recorded by sensors installed in the workings and in Zygmunt ventilation shaft around the time of the accident. The analysis was based on signals recorded by the monitoring system, related to the evolution of methane and fire hazards prior to and after the accident occurred. An attempt was made to identify the cause and the circumstances of the methane explosion at the bottom of the return shaft.
Rock Breaking Mechanism and Process Optimisation of Jet Cutting Basic Roof Rock under Submerged Jet Condition
Authors: Shi Lei , Lu Weiyong , Lv Dong
Published: April 2024

The destruction of rock under the condition of a close submerged jet has become a hot topic of scientific research and engineering application in the past decade. With the unremitting efforts of a large number of experts and scholars around the world, gratifying progress has been made in the research of computational fluid dynamics (CFD) on the internal and external flow fields of the jet nozzle, the theoretical derivation of rock mechanics on the fracture initiation and propagation criteria of hydraulic fracturing, and the numerical simulation of jet erosion mechanism under the coupling of fluid and solid fields, however, for the rock mechanics hydraulic fracturing cutting engineering scale of non-oil drilling fracturing technology, the research on the fluid-solid coupling boundary conditions of fracturing fluid and hard dense rock under the flow state conditions of the submerged field inside and outside the borehole is not sufficient. In the calculation of the fluid-solid coupling boundary flow field under the non-submerged jet state, the control equation with Reynolds number between 2300-4000 shall be selected, while it belongs to the laminar flow state in the stage of hole sealing and pressurised fracturing. Therefore, Von-Mises equivalent plastic stress is selected in the mechanical model to calibrate the failure state of the rock-solid boundary, and the control equations of laminar flow and turbulent flow are selected to calibrate the fluid boundary. The mechanism of different stages of rock breaking by hydraulic fracturing jet can be further analysed in detail, and Comsol 6.0 multi-physical field simulation software is selected for verification. The research results will help deepen the understanding of rock breaking mechanism by jet and optimise the selection of parameters for field construction.
A competency-bazed approach in the environmental education of the students - future biology teachers
Authors: Doychinova Klaida
Published: April 2024

The contemporary trends of globalization and enhanced international cooperation, as well as the aim at building a knowledge-based society, have put higher education institutions in an ever-increasing public interest. The fast-developing digitalization, the implementation of artificial intelligence and especially the generational characteristics of the learners determine the need for new approaches in teaching and learning tailored to individual needs. One of them is the competence approach, which represents one of the leading pedagogical concepts of the 21st century and is the basis for the formation of ecological competence. Its application in pedagogical practice is a serious challenge for both teachers and students – future Biology teachers. The article analyses on a structural and functional basis the components of environmental competence. A theoretical model for the formation of ecological competence in the discipline “Forms and methods of ecological education and upbringing in Biology education”, included in the curriculum of Master degree students is presented. The model is aimed at updating the vision of the learning process in the relevant discipline, the main part of which is environmental education.
Lecanemab: A Second in Class Therapy for the Management of Early Alzheimer’s Disease
Authors: Yoon Connie , Groff Corey , Criss Olivia
Published: April 2024

The Food and Drug Administration granted traditional approval of lecanemab for the treatment of Alzheimer’s disease (AD). Lecanemab is a humanized anti-amyloid monoclonal antibody directed towards Aβ protofibrils. Lecanemab is the only drug that targets Aβ soluble protofils and has shown statistical differences in mild AD or mild cognitive impairment. In its landmark phase III trial, lecanemab was shown to slow the progression of clinical decline, and a reduction in amyloid protein accumulation. The difference in mean CDR-SOB score improvement between the treatment and placebo groups was -0.45, of which the clinical significance could be argued.  Amyloid burden was also considerably reduced as well, but the true clinical consequence of this reduction remains to be seen. This beneficial impact on daily living is offset by rare but serious side effects including amyloid-related imaging abnormalities (ARIA) causing cerebral edema (ARIA-E) or cerebral microhemorrhages or hemosiderin deposits (ARIA-H). Benefits of therapy must be considered against the risk of cerebral microhemorrhages and edema. Affordability must also be taken into consideration. The current estimated yearly cost for twice monthly lecanemab infusion is $26,500. In addition to the significant cost challenges, the frequent infusions may pose concerns related to access. Additional agents within this class are in the pipelines with possibly increased efficacy or decreased adverse events.
Development and Evaluation of a Reliable Medication Management Self-Assessment Checklist
Authors: Isetts Brian , Talley Kristine , Brearley Ann
Published: April 2024

An ability to effectively self-manage medications is the result of several factors influencing a person’s decision to take medications. The need for new approaches to medication self-management are evident in the persistent trends of ineffective and unfortunate medication use consequences, referred to as drug-related morbidity and mortality.  Fortunately, pioneering initiatives have emerged to reshape our approach for developing a rational organizational paradigm so that patients can confidently self-manage medications.

     Favorable outcomes of studies pertaining to the delivery of comprehensive medication therapy management services within the practice of pharmaceutical care prompts the question, ‘Can patients and family members apply the 4-step pharmacotherapy workup process to better organize their decision-making and confidence in medication self-management?’ To answer this question an Effective Medication Self-Management Toolkit based on this 4-step process, and a Medication Management Self-efficacy Checklist, were created and evaluated for feasibility, acceptability, and internal consistency reliability.

     The first evaluation established the preliminary acceptability and feasibility of the toolkit using a convenience sample of 39 residents of independent living facilities in focus group sessions. All participants indicated they perceive that the 4-step process can help individuals successfully self-manage medications. At the conclusion of the focus group sessions, all 39 participants completed the 7-item post-session checklist. This paper presents the second evaluation to establish the internal consistency reliability of the toolkit’s Medication Management Self-efficacy Checklist using Cronbach’s alpha. There was good internal consistency of the self-efficacy checklist with a Cronbach’s alpha value of 0.82.

     This investigation of a novel approach for applying the 4-step pharmacotherapy assessment process by patients suggests that it is feasible and acceptable to use, and that the medication self-efficacy checklist provides a reliable and useful measure of a patient’s confidence in self-managing medications.
The Role of Cognitive-Information Technologies in Cybersecurity: Threat Detection and Adaptive Defense Systems
Authors: Camara Amadou Sara
Published: April 2024

The research delves into the influence of machine learning and artificial intelligence advancements on cybersecurity within software-oriented systems. The author thoroughly examines the modeling of cognitive-information technologies and their ramifications on data analysis, training processes, and decision-making within these systems. Special emphasis is placed on identifying cybersecurity threats faced by artificial intelligence systems, such as susceptibility to cyberattacks. The study proposes adaptive defense components, including behavioral biometrics analysis, automated incident response, user and entity behavior analytics (UEBA), and vulnerability management, to address these threats. These components are underscored in the development of cybersecurity strategies in the contemporary digital environment, crucial for protecting sensitive data and infrastructure. Methodologically, the research involves analyzing existing cybersecurity threats and their impact on artificial intelligence systems, employing data analytics and modeling techniques tailored to information technologies. It also evaluates contemporary methods of adaptive cybersecurity. Key findings of the study not only identify cybersecurity threats to artificial intelligence systems but also propose adaptive defense components for effective mitigation. The research innovatively examines the influence of cognitive information technologies on cybersecurity strategies, offering novel approaches to safeguard data and infrastructure in the modern digital landscape. Additionally, the study highlights examples such as Natural Language Processing (NLP), image and video recognition, predictive analytics, and virtual assistants, which are integral to understanding the breadth of applications of artificial intelligence in cybersecurity. The author significantly contributes through a systematic analysis of diverse threats, culminating in comprehensive recommendations for cybersecurity. Furthermore, the study identifies future prospects for cybersecurity amidst evolving cyber threats, paving the way for further research and development in the field and enhancing understanding and ensuring security in the digital realm.
FAKTOR-FAKTOR YANG MEMPENGARUHI AUDIT DELAY PADA PERUSAHAAN FOOD AND BEVERAGES YANG TERDAFTAR DI BURSA EFEK INDONESIA TAHUN 2018-2022
Authors: Layliya Nurul , Citra Yuliarti Norita , Suharsono Riyanto Setiawan
Published: April 2024

Companies that have gone public or public companies are companies whose shares can be traded to the public, so their financial reports must also be published and accessible to everyone. Regulation of the Financial Services Authority of the Republic of Indonesia of 2016 Number 29/POJK.04/2016 concerning Submission of Annual Reports states that Issuers or Public Companies are required to submit annual reports to OJK (Financial Services Authority) no later than the end of the fourth month. after the end of the fiscal year. The purpose of this study was to determine the effect of extraordinary items, profit/loss, analysis of the effect of company size, audit opinion and KAP reputation on audit delay in Food and Beverages companies listed on the IDX in 2018-2022. The research method used is explanatory research with multiple regression analysis techniques with the help of the SPSS version 22 application. The results of the data analysis obtained show that the larger the Extraordinary Item, the higher the profit/loss, the higher the audit opinion, and the higher the KAP's reputation. according to Audit Delay. Meanwhile, company size has no effect on audit delay.
PENGARUH KEPEMILIKAN INSTITUSIONAL, KOMITE AUDIT DAN KOMISARIS INDEPENDEN TERHADAP INTEGRITAS LAPORAN KEUANGAN
Authors: Abidatus Suroya Naela , Darmayanti Novi , Shoimah Siti
Published: April 2024

ABSTRACT

 

 

This study aims to determine the effect of Institutional Ownership, Audit Committee and Independent Commissioners on the Integrity of Financial Statements, partially or simultaneously. The population of this study were all manufacturing companies in the chemical sub-sector which were listed on the Indonesia Stock Exchange (IDX), totaling 93 companies. This study used the 2018-2022 observation period, using the purposive sampling method to obtain a sample of 70. The data analysis method used in this study was a multiple linear regression test. The variables used are Institutional Ownership, Audit Committee and Independent Commissioners as independent variables, while the Integrity of Financial Statements as the dependent variable. The results of this study resulted in the finding that partially Institutional Ownership, Audit Committees, Independent Commissioners have a significant effect on the Integrity of Financial Statements. Simultaneously, institutional ownership, audit committee and independent commissioners have a significant effect on the integrity of financial statement.
The Influence of Culture and Religion in Coping with a Mental Illness by the Residents of the Eastern Cape Province, South Africa.
Authors: Sikrweqe Odwa , De Klerk Ulricha , Ally Yaseen
Published: April 2024

Culture and Religion are significant constructs in the understanding, diagnosis, and treatment of mental illness, and acknowledging culture and religion is thus essential to effectively engage with all people seeking mental healthcare. This study sought to explore the role of culture and religion in coping with mental illness among people of the Eastern Cape Province in South Africa. The study employed a quantitative exploratory-descriptive approach, with 101 participants taking an online questionnaire as a convenience sample. Descriptive and inferential statistics were used to analyse the data. The findings suggested that there is a link between religion/culture and how people cope with mental illnesses. The study's findings highlight the importance of public education initiatives that recognise and appreciate people's cultural variety and collaboration between traditional and medical experts.
Investigating the Dielectric Photosensitivity of Zinc Oxide Nanostructures Under Ultraviolet Light
Authors: Salahi Esmaeil , Enayati Taloobaghi Hoda , Shahidi Mohammad Mahdi , Ezema Fabian I.
Published: April 2024

In this study, we prepared a ZnO thin film using the sol-gel spin-coating method on glass substrates. We repeated the synthesis procedure once, twice and four times to obtain the samples. We then investigated the FESEM images, XRD diffractograms, Hall effect and dielectric measurement of the samples. We observed the phase transition from the wurtzite to the zinc blende phase as a result of the number of repetitions. The films exhibited direct band gaps ranging from 3.2 eV to 3.3 eV. This result indicate that the two-times synthesis process has considerably affected the morphology and also improved the crystallinity of the layer. The sample of which the surface was covered with nearly uniform short nanorod grains with an average diameter of ~ 180 nm showed the highest sensitivity to ultraviolet light.
Teknologi Produksi Dan Analisis Kelayakan Usahatani Benih Padi Di Provinsi Sulawesi Tengah
Authors: Syafruddin Syafruddin , Padang Irwan Suluk , Muchtar Muchtar , Wahyuni Andi Nirma , Suwitra I Ketut , Rahayu Heni SP , Saidah Saidah
Published: April 2024

Benih merupakan salah satu komponen penting dalam peningkatan produksi dan produktivitas tanaman. Ketersediaan benih unggul dan bermutu padi sawah secara nasional termasuk Provinsi Sulawesi Tengah masih sangat terbatas sehingga menjadi kendala dalam mendukung pencapaian produksi padi. Untuk itu, dilakukan pengkajian model penyediaan benih dalam bentuk berkelompok dan hamparan yang diharapkan dapat menjadi alternatif penyediaan benih padi unggul dan bermutu sesuai dengan preferensi petani serta tersedia tepat waktu. Penelitian dilaksanakan di tiga sentra padi sawah yang kelompok taninya belum terfasilitasi oleh dinas pertanian baik kabupaten maupun provinsi. Penelitian ini bertujuan untuk mengetahui permasalahan pemenuhan benih ditingkat lapangan dan mendapatkan model sistem produksi benih di tingkat petani dan kelompok tani untuk pemenuhan benih unggul dan bermutu secara tepat. Pelaksanaan kegiatan terdiri atas dua tahap yaitu identifikasi dan karakterisasi potensi dan kendala perbenihan dan tahap kedua pengkajian inovasi dan teknologi produksi benih tingkat petani penangkar dan kelompok tani. Hasil penelitian menunjukkan bahwa petani belum mengetahui varietas unggul baru termasuk tata cara dan syarat tanaman untuk dapat menjadi benih serta kesulitan dalam mendapatkan informasi berkaitan dengan benih, sehingga petani menanam varietas yang ada atau mengharap benih bantuan. Hasil panen dan produksi benih di tiga lokasi kegiatan menunjukkan hasil cukup tinggi yaitu mencapai 4,2 – 5,1 ton benih/ha dimana dalam satu ha produksi untuk benih dapat menyuplai benih seluas 100 – 120 ha dan dapat meningkatan keuntungan 2-3 kali lipat dibandingkan dengan produksi gabah. Selain itu, sistem penangkaran skala kelompok petani dapat melihat penampilan tanaman yang akan digunakan menjadi benih
Telang Flower Extract (Clitoria Ternatea) as Antioxidant in Snack Sticks
Authors: Fangohoi Latarus , Aimanah Ummu , Munira Munira , L Andi Besse Sumpala
Published: April 2024

Telang flower (Clitoria ternatea) is a flower that can be grown as an ornamental plant or as a wild plant. It has long been used in traditional medicine and as a food coloring because it contains a number of active ingredients with pharmacological potential. Snack sticks can improve organoleptic quality and antioxidant activity content, this study aims to determine the organoleptic quality, and antioxidant activity content and to find out how to make snack sticks against the addition of telang flower extract as an antioxidant on snack sticks. The study method used was an experimental method of Completely Randomized Design (CRD) with 5 treatments and 3 replications resulting in 15 experimental units with each experiment, namely P0 = no treatment, P1 = 10g telang flower extract + 100ml water, P2 = 20g extract telang flower + 100ml water, P3 = 30g telang flower extract + 100ml water, P4 = 40g telang flower extract + 100ml water. The results showed that the P4 treatment (40g telang flower extract + 100ml water) gave the best results on organoleptic quality with an average score of 11.6, and the best content of antioxidant activity was found in P4 treatment with an amount of 103.52 ppm.

Keywords: extract, Telang flower, stick, organoleptic, and antioxidant
The Different Time Administration of Cherry Leaf Teabag (Muntingia calabura L.) to Broiler Immunity
Authors: Mawarni I , Putri D D , Candra A A , Noviadi R , Maradon G G
Published: April 2024

This study purpose was to analyze the different time administration of cherry leaf teabag (Muntingia calabura L.) to broiler immunity.  This study used 2 treatment groups. The first group (T1) was given cherry leaf teabag (Muntingia calabura L.) every day in drinking water (T1), and the second group (T2) was given cherry leaf teabag (Muntingia calabura L.) every two days. The dosage of cherry leaf used in this study 420 mg/kg BW. Paired samples t-test was used to compare the results of the two treatment groups. To determine the effect of different time administration of cherry leaf teabag on the broiler immunity, the parameter observed was the antibody titer in response to Newcastle Disease vaccination, another parameter observed is the weight percentage of the lymphoid organs (Bursa of Fabricius and Spleen) to find out that the herbs with immunostimulatory activity do not cause lymphoid organs to work excessively does not cause the lymphoid organs to work excessively. Based on the results of this study, it was concluded that giving Cherry leaf teabag (Muntingia calabura L) every two days had almost the same effect in increasing broiler immunity as giving every day, and giving Cherry leaf teabag (Muntingia calabura L) every day also does not have a negative effect on the lymphoid organs which are responsible for immunity
Exploring Midline Asymmetry: A Comprehensive Study Among Adolescents in the North Bihar Population
Authors: Shankar Daya , Anjan Ravi , Choudhary Anuj Kumar , Shankar Rahul , Nanda Medha , Bharti Gayatri
Published: April 2024

Objectives

In the contemporary era, achieving a sense of equilibrium is a paramount concern, and a visually pleasing smile is intricately linked to both professional success and social acceptance. Esthetics, with a specific focus on Oro-facial aesthetics, emerges as a primary motivation for individuals seeking dental treatment. Nevertheless, there exists an optimal and aesthetically pleasing range of dental midline deviation.

The current study aimed to ascertain the prevalence of dental midline shifting and the average extent of midline discrepancy among adolescents (aged 13-17) from North Bihar population.

Material & Methods

Two hundred subjects participated in the study, with 100 males and 100 females selected based on predetermined inclusion criteria. Intraoral frontal occlusion photographs were captured for each participant, and subsequent analysis was done utilizing Digimizer software. Statistical analysis was applied to the linear measurement data obtained through photographic evaluation.

Results

The study’s findings revealed a noteworthy proportion of subjects displaying deviations between upper and lower midlines and anterior teeth midlines, falling within the range of 0.03-3.80 mm.

Conclusion

The prevalence of these deviations was observed to be higher in males compared to females, and this difference was statistically significant.
Stevens-Johnson Syndrome Induced by Methotrexate, An Uncommon Adverse Drug Reaction: A Case Report
Authors: Gupta Vishakha , Abidi Afroz
Published: April 2024

Adverse drug reactions (ADRs) can lead to severe consequences and increased mortality rates. This case report focuses on a 41-year-old woman, who developed methotrexate-induced Stevens-Johnson syndrome (SJS), emphasizing the importance of recognizing and managing such a patient. The patient exhibited recurrent vomiting, maculopapular rashes, erosions and ulcers in multiple locations, consistent with SJS. These symptoms highlight the severity of the adverse drug reaction. Treatment involved was the discontinuation of medications, oral ointments, gargles, prophylactic antibiotics, and blood transfusion. Significant improvement was observed after 15 days of treatment. This case report underscores the life-threatening nature of methotrexate-induced SJS. Early recognition, discontinuation of offending medications, and prompt intervention are crucial to mitigate harm. Raising awareness about ADRs and their management is vital for enhancing patient safety and outcomes.
Safety and Utility of Various Intravenous Access Devices in a Newly Established Pediatric Hematology Oncology Unit in Central India: Is Midline an Acceptable Option?
Authors: Kundavaram Rajkumar , Abraham Anisha Rosilyn , Chaudhary Narendra Kumar , Tadepalli Karuna , Malik Shikha
Published: April 2024

Introduction:

Recent advances in chemotherapy and supportive care have led to improved survival rates in paediatric oncology. Management of these patients requires safe and reliable intravenous access for various purposes, which can be achieved with midline, central venous catheters (CVC), peripherally inserted central catheters(PICC) and chemo-port. Each type of access has a its advantages and disadvantages. We have analysed the safety and utility of various intravenous access devices in pediatric oncology patients.

Methods:

A single-centre prospective observational study was conducted in the Division of Paediatric Haematology Oncology, Department of Paediatrics, in a tertiary care hospital in central India. A total of 32 patients were enrolled (14 Midlines, 12 CVCs, 4 PICCs, 2 Chemo-ports). These were observed for catheter dwell time and complications.

Results:

The median dwell time for all types of catheters was 30 days. The longest median catheter dwell time was for chemo-port (101 days), followed by midlines (30.4 days). The most frequent complication encountered in our study was thrombophlebitis (28%), followed by central line-associated bloodstream infections (CLABSI- 22%). Among CVCs, the most frequent complication was CLABSI(11.9 per 1000 catheter days). Among Midline catheters, the most frequent complication was thrombophlebitis(18.8 per 1000 catheter days). Among PICCs, one each of catheter leak, catheter fracture, thrombophlebitis and CLABSI was seen (21.7 per 1000 catheter days). Both chemo-ports were removed due to complications (one due to CLABSI and the other due to catheter migration into the right atrium).

Conclusions:

Midlines can be used at newly established paediatric oncology centres as serious complications (CLABSI and deep catheter migration) are less common with midlines.
Ratio of Metastatic Lymph Nodes: A Significant Prognostic Factor in Patients with Oral Squamous Cell Carcinoma
Authors: Kumar Anshuman , Roy Birsubhra , Aiyer HemaMalini , Rawat Garima
Published: April 2024

Background:

One of the significant prognostic factors for survival in squamous cell carcinoma of the oral cavity is the presence or absence of cervical metastasis. Thus, management of cervical lymph nodes becomes a vital component of the overall treatment strategy for patients with cancers of the head and neck. The aim of this study was to investigate the prognostic value of the ratio of metastatic lymph nodes in patients with oral squamous cell carcinoma.

Methods:

A retrospective analysis of 225 biopsy-proven oral squamous cell carcinoma (OSCC) patients with T1-T4a status of the primary tumor was done. All cases had a history of surgical excision of the primary lesion and neck dissection with a follow-up period of two years. Primary tumor sites include viz buccal mucosa, tongue, alveolus, gingivo-buccal sulcus and retromolar trigone. Patients with loco-regionally advanced disease and a history of any previous surgery or radio-therapeutic treatment of the head and neck were excluded from the study. Locoregional recurrence, disease-free survival, and the associations between clinicopathological features and recurrence were analysed using univariate and multivariate analysis. p-value ≤ 0.001 was found to be significant. Survival curves were plotted using the Kaplan-Meier method for 5-year disease-free survival.

Results:

The patients with positive lymph nodes were divided into high- or low-risk groups using the best nodal parameter cut-off values (0.06). Our univariate analysis showed a significant correlation between locoregional recurrence and type of neck dissection, pN classification, staging, extranodal extension, perineural invasion, and ratio of metastatic lymph nodes (RML). However, on multivariate analysis, RML showed an independent prognostic predictor (p= 0.04) for locoregional recurrence.

Conclusion:

The findings of our study suggest that RML is a strong independent predictor of prognosis in patients with oral squamous cell carcinoma.
Household Survey to Evaluate the Coverage of Mass Drug Administration for the Lymphatic Filariasis in District Umaria, Madhya Pradesh, India in Year 2023
Authors: Kabirpanthi Vikrant , Singh Akash Ranjan , Kahar Priti , Pathak Astha , Pandey Satyendra , Jayswar Himanshu
Published: April 2024

Background:

In 2023, the Umaria district in Madhya Pradesh, India, was identified as an endemic district for Lymphatic Filariasis (LF). The National Programme for Elimination of Lymphatic Filariasis conducted annual mass drug administration (MDA) campaigns in February to eliminate LF by 2027.

Objective:

This study aimed to estimate the coverage and compliance rate of MDA in the Umaria district of Madhya Pradesh, India, in 2023.

Methodology:

A cluster sampling method was used for evaluation. The district was divided into three implementation units, corresponding to its three administrative blocks. Four clusters were selected within each unit, consisting of one urban and three rural clusters. Thirty households were randomly selected as respondents from each cluster. Data was collected in May 2023 using a standardized coverage evaluation form designed by the World Health Organization.

Result:

Among the 360 households surveyed, information on 1606 beneficiaries was obtained. MDA was offered to 94% of the total population, with a coverage and compliance rate of 98.5% among the eligible population. The most common reasons for not consuming the drugs were "not present at house during the campaign" and "fear of drugs." Less than one percent of beneficiaries reported any side effects following the consumption of MDA.

Conclusion & Implication:

The coverage and compliance of MDA in the district appear to be optimal. The National Programme for Elimination of Lymphatic Filariasis should now consider conducting Transmission Assessment Surveys to determine the endemicity of districts that have reached the critical threshold of LF infection. Additionally, establishing adequate sentinel sites, organizing night blood examination camps in endemic areas, and improving Information Education Communication activities may aid in achieving LF elimination by 2027.
Tumor Anti-angiogenesis: Nano-Arsenal will Kill the Crab
Authors: Alam Feroz , Akhtar Kafil , Maheshwari Veena , Hasan Mahboob
Published: April 2024

Angiogenesis: the process of developing new blood vessels from the pre-existing ones is a very crucial process in tumor formation, growth, progression and metastasis. The central role of angiogenesis in tumor growth and progression compels targeting tumor vasculature as a therapeutic mean. Nanoparticles have revolutionized the domain of cancer therapeutics, molecularly targeted anti-cancer drugs represents one of the most significant recent advances in clinical oncology. Various types of nano-drug complexes which targets tumor vasculature preferentially, are being increasingly tested for optimal therapeutic efficacy and minimal side-effects. Here, we review some of these anti-angiogenic nano-drug complexes.
Book Culture is the Foundation of Civilization (in Memory of Arkady Vasilyevich Sokolov)
Authors: Stolyarov Yury N.
Published: April 2024

The article traces the evolution of views of the outstanding culturologist, documentologist and librarian Arkady Vasilyevich Sokolov (10.02.1934—16.11.2023) on the integral science, summarizing many related disciplines. At first he assigned this role to informatics, then to bibliofuturology, pinning his hopes on the fact that in the future of Russian books “library humanism” will triumph - the main pivot and target of all scientific work of A.V. Sokolov. In 2019, he rose to a new level of abstraction, reaching the concepts of bibliosphere and documentosphere derived from the concept of noosphere and concluding that their theoretical generalization is bibliosophy. By 2020 A.V. Sokolov began to investigate the phenomenon of library post-modernity. He did all this in order to substantiate at a fundamental general theoretical level the notion of humanistic book culture opposing digital culture. A.V. Sokolov defended the concept that the library is a humanistic stronghold of the nation, and digitalization (informatization, automation) is an auxiliary means to strengthen book culture as a basic value of culture.
Between Two Worlds: the Image of a Dybbuk on the Modern Opera Stage
Authors: Krom Anna E.
Published: April 2024

The article is devoted to the theme of the artistic embodiment of the Hebrew legend of the dybbuk on the modern opera stage. The legends about the restless soul of a sinner, “stuck” between two worlds — the world of the living and the world of the dead — are reflected in the works of famous Jewish writers of the turn of the 19th—20th centuries. They received their first vivid refraction in drama in the play “Between Two Worlds (Dybbuk)” (1915) by the outstanding folklorist and ethnographer Semyon Akimovich Ansky. The story of the dybbuk, heard by Anton during folklore expeditions in Volhynia and Podolia, is reinterpreted by the playwright, “overgrown” with complex literary and philosophical connotations. The dramatic play is literally saturated with music: songs, dances, prayers and Hasidic melodies, one of which — “Mipney ma” in the genre of nigun — becomes the leitmotif of the work. The masterpiece of Ansky, reflecting the specifics of the everyday, cultural and religious life of the Hasidic community of the early twentieth century, gave rise to an extensive body of musical and theatrical works — more than ten over the last century (operas by L. Rocca, D. Tamkin, ballet by L. Bernstein, etc.). The article discusses the multimedia chamber opera “Dybbuk. Between Two Worlds” (2007) by the Israeli-American composer Ofer Ben-Amots through the prism of a dialogue with the original source. Previously, Ben-Amots’s musical work had not been studied in Russian art criticism, which predetermined the novelty of the chosen topic. The musician interprets the main ideas of Ansky’s dramatic play in his own way, presenting the image of the dybbuk as an allegory of the “borderline” existence between two worlds, turns to the traditional musical culture of Judaism (conducts the nigun “Mipney Ma” as the leitmotif of the opera, brings to the fore the timbres of the violin and clarinet, uses special techniques of sound production on these instruments associated with music playing in Klezmer chapels, stylizes the folklore of Jewish towns).
Menteş Yarımadası’nın Neojen Jeolojisi, Batı Anadolu
Authors: Göktaş Fikret
Published: April 2024

Foça Çöküntüsü’nün Urla bölümünde yer alan Menteş Yarımadası’nın karasal Neojen istifi Orta Miyosen yaşlı Urla Grubu ile simgelenir. Geç Erken Miyosen yaşlı Kocadağ Volkanitleri üzerinde uyumsuzlukla yer alan Urla Grubu, sedimanter ve volkanik kaya birimlerinden oluşur. Egemen olarak gölsel çökellerden oluşan sedimanter istif, alüvyon yelpazesi tortullaşmasını yansıtan Bozavlu Formasyonu ile başlar, gölsel kıyıyüzünde çökelmiş volkanosedimanter Güvendik Formasyonu ile devam eder ve Urla Kireçtaşı ile son bulur. Güvendik istifi, Menteş volkanizmasının erken dönemini yansıtan epiklastik (lahar ve türbiditik kumtaşı) ve piroklastik (ignimbirit, temel türbülansı, bloklu kül akışı) fasiyeslerdeki volkanoklastik yoğunluk akıntısı düzeylerini sıklıkla içerir. Güvendik Formasyonu üzerine uyumlu gelen Urla Kireçtaşı istifi, Menteş volkanizmasının kül döküntüsü fasiyesindeki tüf arakatmanlarını alttan üste içerir. Kireçtaşı istifinin tabanında ve transgresif aşmalı kesimlerinde, kıyı önü kuşağında dalgalarla işlenerek oluşmuş algal biyoklastitler ve onkoidal kireçtaşları çökelmiştir. Menteş Yarımadası’nın Orta Miyosen alkali volkanizması, Menteş Volkanitleri ve Ovacık Bazaltı ile temsil edilir. Trakit-riyolit bileşim aralığında ürünler veren Menteş volkanizması, piroklastikler ile kompozit lav domları ve dom-akıntılarından oluşur. Piroklastik istif, Ovacık Bazaltı’ndan türemiş lav parçaları içeren kaynaklanmamış ignimbiritlerle başlar, bloklu kül akışı ve temel türbülansı ardışık düzeyleri ile devam eder. Menteş volkanizması, Güvendik ve Urla Kireçtaşı birimlerinin çökeldiği göl içinde evrimleşmiştir. Menteş asidik volkanizmasıyla yanal ilişkili gelişim gösteren Ovacık bazik volkanizması, Urla Kireçtaşı çökeliminin başlangıcından son dönemlerine kadar aralıklı etkinliğini sürdürmüştür.
Bozdağ (Karaburun Yarımadası) Kütlesi Üzerinde Dolinlerin Morfotektonik Gelişimi
Authors: Şener Mehmet Furkan
Published: April 2024

Bu çalışmada Karaburun Yarımadası’nın kuzeyinde yer alan Bozdağ Kütlesi üzerindeki dolinlerin morfotektonik ve morfojenetik özellikleri incelenmiştir. Çözünme dolinleri orta enlemlerdeki yüksek karstik platoların karakteristik yüzey şekillerindendir ve dolin morfometrileri karstik platoların morfotektonik gelişim özelliklerinin incelenmesinde sıklıkla kullanılan yöntemlerden bir tanesidir. Bu çalışmada dolinlerin alansal dağılışları, yoğunlukları ve morfometrik özelliklerinin belirlenmesi için yüksek çözünürlüklü sayısal yükseklik modeli üzerinden otomatik çıkarım tekniği kullanılmıştır. Dolinlerin belirlenmesinin ardından alan, çevre uzunluğu, dairesellik indisi, uzunluk, genişlik ve uzama oranları gibi farklı morfometrik parametreler hesaplanmıştır. Yapılan analizler ve elde edilen sonuçlara göre, alanda toplam 564 dolin tespit edilmiştir ve maksimum yoğunluk 74 dolin/km2’ye kadar ulaşmaktadır. Ortalama yüksekliği 1.080 metre olan dolinlerin tamamı Camiboğazı Formasyonu olarak adlandırılan kireçtaşları üzerinde yer almaktadır. Dolinler paleotektonik evrimi ile başlayan ve Karaburun Platformu’nun İzmir-Ankara Zonu’nda Kretase döneminde etkisi altında kaldığı tektonik aktivitelere bağlı olarak yaklaşık KB-GD doğrultusunda, alandaki çizgiselliklere paralel bir yönelim göstermektedir.
Green synthesis of gold nanoparticles obtained from Punica granatum flower extract for phytochemical determination and antibacterial activity
Authors: Shanmugapriya Sakkaravarthy , Divyadharshini Senthilkumar , Kanagaraj Chinnasamy
Published: April 2024

Numerous biomedical applications such as biological detection, drug delivery, diagnostic imaging and tissue engineering, have incorporated nanotechnology. Parts of the pomegranate (Punica granatum) flower are known to have strong antibacterial properties. In this study, the anti-susceptibility test was used to look into the green synthesis of gold nanoparticles using Punica granatum and the inhibitory effect of these particles. According to the current study, prepared AuNPs were evaluated using a variety of methods including UV-visible spectrophotometry, FTIR, SEM and GC-MS to identify the phytochemicals. The bacterial and fungal species Candida albicans and Malassezia furfur that are inhibited by the synthetic colloidal gold nanoparticles made with Punica granatum flower extract include Escherichia coli, Pseudomonas, Staphylococcus, Klebsiella pneumoniae and Protea. In this work, we describe a simple, quick and reproducible method for the environmentally friendly synthesis of AuNPs without the need for expensive reducing agents. Simple incubation of a flower extract with aqueous gold ions at ambient temperature resulted in ‘medium monodisperse’ nanoparticles, suggesting that the plant extract acted as a strong reducing agent.