bluuebunny/crossref_metadata_2025 huggingface dataset:
imitateur moderne des Primitifs flamands établi en Espagne: le Faussaire de Valls Marín
Authors: Martens Didier , Dimov Alexandre
Published: October 2019

Le Faussaire de Valls Marín peut être considéré comme l’un des imitateurs de la peinture des anciens Pays-Bas ayant connu le plus grand succès, une sorte de Joseph Van der Veken ibérique. Il semble avoir travaillé durant la première moitié du XXe siècle, principalement pour le marché d’art espagnol. Il réussit à vendre des peintures de sa main comme des œuvres flamandes authentiques à des collectionneurs renommés, tels l’éditeur José Lázaro Galdiano, le médecin Carmelo Valls Marín et l’historien d’art José Camón Aznar. Ses sources principales furent probablement des photographies de tableaux de Jan van Eyck, Rogier van der Weyden et Hans Memling. À l’occasion, il prit aussi pour modèles des œuvres allemandes. Comme de nombreux faussaires de son époque, il eut une activité de restaurateur. Parfois, il alla bien au-delà de la simple restauration d’une peinture ancienne et chercha à augmenter sa valeur marchande en y ajoutant des visages et des détails d’architecture dans le style des Primitifs flamands. L’une de ses ‘hyperrestaurations’ les plus spectaculaires concerne une Présentation au Temple due à un artiste aragonais: le Maître de Sijena. De ce tableau du début du XVIe siècle, il a tenté de faire une œuvre de Memling.
Perlakuan Benih Ekstrak Anredera cordifolia Menekan Kejadian Penyakit Antraknosa Benih Cabai Terinfeksi Colletotrichum Acutatum
Authors: Yulia Endah , Muhadam Hadi Syahir , Widiantini Fitri , Kurniawan Wawan
Published: October 2019

Keberadaan patogen pada benih telah menimbulkan kerugian yang tinggi. Perlakuan benih sudah umum dilakukan untuk menjamin benih bebas hama maupun patogen serta untuk menyediakan pengendalian penyakit selama masa perkecambahan maupun pada awal pertumbuhan tanaman. Penyakit antraknosa pada tanaman cabai yang disebabkan oleh Colletotrichum spp. dapat mengakibatkan kehilangan hasil panen mencapai 100%. Infeksi patogen penyebab penyakit antraknosa pada benih dapat mengakibatkan penyakit hawar bibit atau pre emergence atau post emergence damping-off. Penggunaan bahan alami untuk perlakuan benih diharapkan dapat menjadi upaya pengendalian penyakit yang ramah lingkungan. Tujuan dari penelitian ini adalah untuk menguji keefektifan ekstrak daun binahong (Anredera cordifolia) dalam menekan kejadian penyakit hawar bibit yang disebabkan oleh jamur Colletotrcihum acutatum terbawa benih cabai. Percobaan dilaksanakan di Laboratorium Bioteknologi Proteksi Tanaman, Departemen Hama dan Penyakit Tumbuhan, Fakultas Pertanian, Universitas Padjadjaran. Percobaan terdiri atas tujuh perlakuan yaitu empat perlakuan benih dengan ekstrak binahong konsentrasi 0,25%, 0,50%, 1%, dan 2%, serta dua perlakuan kontrol positif dan negatif, dan perlakuan pembanding fungisida propineb 0,30% yang masing-masing diulang empat kali. Hasil percobaan menunjukkan perlakuan benih cabai dengan ekstrak metanol daun binahong mampu menekan kejadian penyakit hawar bibit pada benih terinfeksi C. acutatum dengan penekanan penyakit tertinggi sebesar 81,65% yang diperoleh pada perlakuan konsentrasi 2%. Namun demikian, perlakuan benih cabai dengan ekstrak metanol daun binahong memengaruhi viabilitas benih cabai dengan panjang kecambah benih cabai yang lebih pendek daripada pada perlakuan kontrol.Kata Kunci: Binahong, Pestisida nabati, Perlakuan benih
Uso de Sacarose na Desintoxicação de Plantas de Cafeeiro Submetidas à Deriva de Glyphosate
Authors: Tadin Sardinha Levy , Miranda Machado Caroline Maira , Alves Macedo Leandro , De Oliveira Ferreira Brendo , Cabral França André , Aparecido dos Santos Edson , Vieira Araújo Fausto Henrique , Neiva Júnior Eudes
Published: October 2019

O objetivo do trabalho foi avaliar o potencial da sacarose na desintoxicação de plantas jovens de cafeeiro atingidas por glyphosate. O experimento foi conduzido em casa de vegetação, no setor de Cafeicultura do Departamento de Agronomia da Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM). O delineamento experimental utilizado foi em blocos casualizados em esquema fatorial 3 x 4, com três cultivares de café arábica (Catuaí IAC 144, Icatu e Catiguá MG2) e quatro sub doses de sacarose. As plantas foram submetidas a 720 g ha-1 de glyphosate, simulando uma deriva acidental, com tratamentos de solução de sacarose nas concentrações de 0%, 1%, 2% e 4%. Os parâmetros avaliados foram intoxicação, crescimento e características fisiológicas. As plantas apresentaram clorose em folhas novas, nas regiões meristemáticas das plantas, sendo a cultivar Icatu a mais afetada. Nos parâmetros fisiológicos, observou-se que em doses iguais ou superiores a 2%, a sacarose foi eficiente no processo de reversão de intoxicação das cultivares utilizadas. Nos parâmetros de crescimento, a sacarose contribuiu para o aumento de biomassa das plantas do cafeeiro, com o aumento das concentrações, com efeito acentuado nas cultivares Catiguá MG2 e Catuaí IAC 144. Os dados foram submetidos à análise de variância pelo teste F a 5% de probabilidade, sendo ajustadas equações de regressão para subdoses de sacarose e realizado teste de média para verificar diferenças entre as cultivares testadas.
CORRELATION OF AA INDEX WITH DEGREE OF LIVER FIBROSIS IN CHRONIC HEPATITIS B PATIENTS
Authors: Andriany Rika , Samad Ibrahim Abdul , Arif Mansyur
Published: October 2019

A liver biopsy is the gold standard for diagnosing and staging liver fibrosis in chronic hepatitis B patient but with many disadvantages so it is difficult to use as a routine examination. Research on index based on serum marker is helpful in predicting liver fibrosis. We conducted a study of the alpha-fetoprotein (AFP) and partial activated thromboplastin time (APTT) index or AA index in relation to the degree of liver fibrosis in chronic hepatitis B patients. This study was a retrospective cross-sectional study in dr.Wahidin Sudirohusodo Hospital Makassar by taking the data from medical records of chronic hepatitis B patients from January 2015 to December 2016. Samples were chronic hepatitis B patients who were tested for AFP, APTT and Fibroscan. The result showed the total of 79 chronic hepatitis B patients, 23 with severe fibrosis, 9 with moderate fibrosis, 26 with mild fibrosis, and 21 with no fibrosis. Spearman correlation test showed a significant correlation between the AA index and the degree of fibrosis (p <0.001) and showed a positive correlation between both of them with a very strong correlation (r = 0.830). Oneway Anova test showed a significant difference between the AA index and the  degree of fibrosis (p<0.001). The results of this study indicate that the AA index can be used as a predictor of fibrosis in chronic hepatitis B patients. It is suggested to do another study with larger sample based on the degree of fibrosis.
MULTIDRUG-RESISTANT ACINETOBACTER BAUMANNII PREVALENCE AND CHARACTERISTICS IN DR.WAHIDIN SUDIROHUSODO GENERAL HOSPITAL OF MAKASSAR
Authors: Tungadi Dewi , Sennang Nurhayana , Rusli Benny
Published: October 2019

BackgroundMultidrug-resistant Acinetobacter baumannii (MDRAB) is a strain of Acinetobacter baumannii which is resistant to three or more classes of antibiotics. As prevalence of MDRAB increases, the antibiotics of choice become limited. Identification of MDRAB is required to manage and control infection.MethodThis was a retrospective study, conducted in Dr. Wahidin Sudirohusodo General Hospital of Makassar, dated from January to December 2016. Bacterial identification and antimicrobial susceptibility testing (AST) were performed using VITEK 2. The patient data were obtained from electronic medical records.Results and DiscussionA total of 323 Acinetobacter baumannii isolates were obtained, consisted of 188 isolates in January-June 2016 and 36 of which was MDRAB (19.15%) with the average length-of-stay 33 days; and 135 isolates in July-December 2016 and 31 of which was MDRAB (22.96%) with the average length-of-stay 27 days. MDRAB was mostly discovered from patients using 3 or more medical devices and on single antibiotic therapy. MDRAB isolates were mostly obtained in sputum and pus specimens, and majority of patients had respiratory diseases. The result of AST showed 100% and 96% susceptibility to Polymyxin B; 71.43% and 54.84% susceptibility to Amikacin; 66.67% and 50% susceptibility to Trimethoprim/Sulfamethoxazole in January-June and July-December 2016, respectively.Conclusion and SuggestionsThe prevalence of MDRAB in our hospital in 2016 was high, suggesting the needs to improve hospital infection prevention and control. Polymyxin B, Amikacin, and Trimethoprim/Sulfamethoxazole are the antibiotics of choice to treat MDRAB.
ANALYSIS OF HEMOGLOBIN LEVELS AND LEUKOCYTE COUNT IN NEONATES WITH HYPERBILIRUBINEMIA
Authors: Suharti Dewi , Wibawa Sulina Yanti , Mutmainah Mutmainah
Published: October 2019

Hyperbilirubinemia is one of the most common clinical phenomena in neonatal patient. Etiology is generally physiological, only about 10% being pathological. It is important for clinicians to distinguish between physiological and pathological hyperbilirubinemia, because uncontrolled pathological conditions can cause severe complications of kern icterus, one ofthe causes of death in infants.This study was retrospective study by obtaining data of all neonatal patients with diagnosis of hyperbilirubinemia, who undergone hemoglobin and leukocyte count test. The data were classified into two groups: physiological and pathological hyperbilirubinemia. Statistical tests were performed to assess the association of hemoglobin levels and leukocytes count between the two groups. A total of 144 data were collected, 54 physiological and 90 pathological hyperbilirubinemia. In physiological hyperbilirubinemia, hemoglobin levels and leukocyte counts were found to be normal, whereas in pathological anemia and leukocytosis developed and the difference between the two groups was statistically significant (p<0,001). Anemia was found in neonates with pathological hyperbilirubinemia caused by RDN, LBW, sepsis, hemolytic, and hemorrhagic. Leukocytosis was found in pathological hyperbilirubinemia caused by sepsis.There was a significant difference between the incidence of anemia and leukocytosis in physiological and pathological hyperbilirubinemia. It can be concluded that routine blood tests can be used to distinguish whether hyperbilirubinemia experienced by neonatel patient is a physiological or pathological condition, so it can be one of the tests suggested when the neonate is hyperbilirubinemia.
THE COMPARISON BETWEEN HBA1C AND GLYCATED ALBUMIN LEVELSIN PATIENTS WITH DIABETES MELLITUS TYPE II WITH OR WITHOUT CHRONIC KIDNEY DISEASE
Authors: Rusli Muhammad , Zulfikar Zulfikar , Syafril Santi
Published: October 2019

The most appropriate marker to assess the glucose level of diabetes mellitus patient with chronic kidney disease has not been recognized. The reduction of an erythrocyteslifetime will pull down the HbA1c from a patient with chronic kidney disease. Beside HbA1c, Glycated Albumin (GA) is an alternative glycemic marker. The aim of this study is to find out whether there is a comparison of HbA1c and glycated albumin levels in patients with type 2 DM with and without Chronic Kidney Disease (CKD). This research is an observational analytic study with a cross-sectional design. Conducted on 46 patients with DM type 2 with or without CKD at the Adam Malik Hospital, from August 2016 – December 2016 that fulfill the criteria, and after that, the HbA1c and GA were examined. The GA level in patients with DM type II and CKD (18.48±5.23)%, were not significantly different from those patient with DM type II without CKD (17.39±6.07)%. From the statistical test result, there is no significant difference of GA from patient with DM type II with CKD and without CKD (p=0.519)and so does the HbA1c levels in type 2 DM patients with CKD (8.1±1.74)% were lower than those patient with type 2 DM without CKD (8.6±1.67)% although there was no significant difference between  HbA1c level from patients with type 2 DM without CKD and with CKD (p=0.364) from the statistical test result. There is no significant difference between HbA1c level and glycated albumin from patients with DM type II with or without CKD.
CORRELATION OF TOTAL LYMPHOCYTE COUNT WITH CD4 COUNT IN HIV/TB COINFECTED PATIENTS
Authors: Rampo Herniaty , Bahrun Uleng , Arif Mansyur
Published: October 2019

HIV-TB co-infection is a global challenge in the healthcare world. HIV infection causes CD4  to decrease which has a role in TB immunity. CD4 as a marker for HIV progression have expensive cost and not available in all healthcare facilities, so WHO recommended TLC as a substitute for CD4. This study aims to determine the correlation of TLC and CD4 in HIV-TB co-infection patients.This was a retrospective study using medical records of hospitalized patients with HIV-TB co-infection in Dr.Wahidin Sudirohusodo Hospital. The correlation was analyzed by Spearman test. CD4 data were divided into two groups: CD4 < 200 cells/mm3 and CD4 â‰¥ 200 cells/mm3 and Mann-Whitney test was performed. Data were also analyzed by ROC curve.In total 172 data with diagnosis of HIV-TB co-infection, Spearman test showed a positive correlation between TLC and CD4  with moderate correlation strength (p <0.001 and r = 0.56). Mann-Whitney test showed  a significant difference between CD4 < 200 cells/mm3 and CD4 â‰¥ 200 cells/mm3 (p < 0.001). ROC curve analysis showed that TLC has a good accuracy value for predicting CD4 in CD4 < 200 cells/mm3 (AUC = 0.911). Sensitivity  88.9% with specificity 84.7% was found in TLC 1154.9 cells/mm3 which predicted CD4  < 200 cells/mm3.There was a positive correlation between TLC and CD4 with moderate correlation strength. TLC can predict CD4 in CD4 <200 cells/mm3. We suggest further studies on patients who receive drug therapy.
RAPID PROGRESSION OF CLAVICULAR SOLITARY PLASMACYTOMA TO MULTIPLE MYELOMA
Authors: Gunawan Hantoro , Notopuro Paulus Budiono
Published: October 2019

Introduction: Solitary plasmacytoma is a monoclonal plasma cell malignancy restricted to one tumor. Fifty percents of cases can progress to multiple myeloma (MM). Median time to progression is 19 months. A case about plasmacytoma progressing rapidly to MM within 2 months from initial diagnosis is hereby described. Case:  A 45-year-old male, attended the Surgery clinic with the chief complaint of progressive swelling on the left neck for two months. Physical examination revealed a fixed, solid, 8x8 cm mass on the left supraclavicular. FNAB showed plasmacytoma. Surgical biopsy and immunohistochemistry confirmed the diagnosis of plasmacytoma. Ki67 index was 80%. There was no abnormality in laboratory examination. Two months later he was admitted to the Internal ward with anemia and kidney disorder. Serum protein electrophoresis revealed M-spike. BMA showed plasma cell proliferation with 78% proportion, which confirmed the diagnosis of MM. Discussion: Solitary plasmacytoma can occur on any bone, mostly on axial bones. Solitary plasmacytoma on clavicle is very rare, with prevalence 0.45% of all primary bone tumors. Diagnosis of solitary plasmacytoma relies on tissue biopsy, laboratory, radiology and bone marrow aspiration. Progression of plasmacytoma to MM can be detected from CBC and clinical chemistry results. Serum protein electrophoresis and bone marrow aspiration results confirmed the diagnosis of MM. High proliferation index (Ki67>8%) and tumor size(>5cm) were the risk factors for rapid progression of plasmacytoma. Conclusion: Early detection of systemic symptoms is very important in the management of solitary plasmacytoma. Keywords: solitary plasmacytoma, multiple myeloma
HORMONE EXAMINATION IN MENOPAUSE
Authors: Marpaung Ferdy Royland , Butarbutar Trieva Verawaty , Soehita Sidarti
Published: October 2019

World Health Organization (WHO) and Stages of Reproductive Aging Workshop (STRAW) define menopause as a permanent end point of menstrual cycle that occurs naturally or by induction of surgical procedure, chemotherapy, or radiation. Clinically, menopause involved women over 40 or 50 years old. Approximately, fifty million women in the world is experiencing menopause annually. The etiology of menopause is classified into physiologic and non-physiologic. Pathophysiology of menopause includes decline of ovary function in menopause, response to loss of ovarian feedback mechanism, decline of hypothalamus and pituitary function. Endocrine changes in menopause lead to alteration of gonadotropin secretion cycle patterns, changes in steroid and peptide hormones through monophasic patterns to increase gonadotropin, decrease of estrogen, progesterone and inhibin. Clinical symptoms of menopause or estrogen deficiency syndrome classified into short term clinical symptoms and long term clinical symptoms. Hormonal examination in menopause consist of Follicular Stimulating Hormone (FSH), Anti-Mullerian Hormone (AMH), Luteinizing Hormone (LH), Inhibin B and Estradiol. The important of time to examine the hormones should be considered carefully.
COMPARISON OF AUTOMATIC STARRSED RS ERYTHROCYTE SEDIMENTATION RATE WITH MANUAL WESTERGREN METHOD
Authors: Sukartini Ninik , Suparmin Siskawati
Published: October 2019

This study aimed to compare the results of ESR measurements using Starrsed RS (30- and 60-minute mode) and manual Westergren method. We also investigate the effect of high leukocytes and haematocrit (Ht) on Starrsed RS ESR measurements. A cross-sectional study using K3EDTA anticoagulated blood samples from 140 subjects were conducted. A total of 21 samples with leukocytes count >50 000/µl were examined. The effect of Ht was studied using data from comparative study subjects.  The 60-minute mode Starrsed RS correlated very strongly [r = 0.98 (95%CI 0.97 to 0.98), p <0.0001], had good agreement [mean bias -0.4 mm (95%CI -1.46 to 0.74)], and gave no significant different results with manual Westergren method. The 30-minute mode Starrsed RS also has a very strong correlation [r = 0.97 (95%CI 0.96 to 0.98), p<0.0001] and good agreement [mean bias-2.9 mm (95%CI -4.23 to -1.58)], but has systematic difference with manual Westergren method. There was significant difference between manual method and Starrsed RS in samples with high leukocytes (p = 0.0208). There were no significant differences of ESR results measured by Starrsed RS dan manual Westergren method in the group of Htâ‰¤35% and >35%. The ESR on the Starrsed RS should still be read at 60 minute. Leukocytes>50 000/µl may affect ESR measurements on Starrsed but no effect of haematocrit was observed.
NITRIC OXIDE AND ABSOLUTE NEUTROPHIL COUNT CORRELATION WITH OUTCOME IN ACUTE ISCHEMIC STROKE PATIENTS
Authors: Harlianti Rina , Anwar Yuneldi , Ganie Ratna Akbari
Published: October 2019

Nitric Oxide (NO) has a dual role as neuroprotector and neurotoxic in the pathophysiology of brain ischemia. Patients with acute ischemic stroke often have increased leukocyte count when admitted to hospital. Patients with acute ischemic stroke with high leukocyte count often have poor clinical outcomes. This study aims to determine the correlation of Nitric Oxide (NO) levels and  Absolute Neutrophil Count with patients with outcome of acute ischemic stroke patients. The study was a longitudinal prospective study, conducted from June to October 2017, sampling was done three times day 1,3,7. Nitric oxide and absolute neutrophil count were examined. NO examination using Chemwell Analyzer and Absolute neutrophil count using SYSMEX XN-1000. 21 patients participated in the study (14 males (66.67%), 7 females (33.33%), Anova test had no difference in absolute neutrophil counts on day 1,3,7 (p = 0,001) and kruskall test. There was no difference between the levels of Nitric oxide days 1,3,7 (p = 0.716). Spearman's correlation test results there were no relation between absolute neutrophil count and outcomes in acute ischemic stroke (p = 0.001) and no nitric oxide relationship with outcome (p > 0.05). The absolute neutrophil count can be an outcome in acute ischemic stroke patients, so it is recommended that the clinician observes the absolute neutrophil count and can be used as a prognosis in acute ischemic stroke patients and to perform more specific nitric oxide examinations (eNOS, nNOS, iNOS) in ischemic stroke patients
CORRELATION BETWEEN INTERFERON GAMMA RELEASE ASSAY OF ELISPOT METHOD AND CD4+ T LYMPHOCYTE CELL COUNT IN HIV POSITIVE PATIENTS
Authors: Ambar Nabil Salim , Aryati Aryati , Kusmiati Tutik , Triyono Erwin Astha
Published: October 2019

Introduction. HIV is a virus that can cause AIDS, which affects the immune system and weakens the body function in fighting disease. The primary cells that HIV attacks are CD4+ T lymphocytes. Opportunistic Infections (OIs) are the biggest risk factors of death in HIV patients and occur in CD4+ T cells <200 cells/Î¼L lymphocytes. TB is a disease with a high mortality rate in the world where Indonesia is a TB endemic country with the highest morbidity rates of TB in the world. The most common OI in people with HIV is TB. The number of limitations on Tuberculin Skin Test (TST) is large, thus in vitro T cells test with (Interferon Gamma Release Assay) IGRA is used in diagnosing latent TB. The aim of this study was to determine the correlation between IGRA ELISPOT method and CD4+ T lymphocyte cell count in HIV positive patients.Method. This was an observational analytical study with cross sectional design. The number of samples was 56 HIV positive patients who were treated at the UPIPI Clinic of the Dr Soetomo Surabaya Hospital. The examination of CD4+ T lymphocyte count was perfomed with FACSCalibur and IGRA was examined with T-SPOT.TB. The results were analyzed using Spearman correlation test.Results. CD4 + lymphocyte cell counts based on WHO groupings were as follows: > 500 cells / Î¼L (33.92%), 200-349 cells / Î¼L (25%), 350-499 cells / Î¼L (25%) and <200 cells / Î¼L (16 , 07%). IGRA examination results showed 35.18% positive and 64.81% negative. The grouping of CD4+ T lymphocyte cell counts based on IGRA test results was 27.77% with positive IGRA and 48.14% with negative IGRA. Spearman correlation test between CD4+ T cell lymphocytes with IGRA in HIV positive patients showed r = 0,036 (p = 0,794).Conclusion. There was no correlation between interferon gamma release assay of ELISPOT method and CD4+ T lymphocyte cell count in HIV positive patients.
ANALYSIS OF LACTIC AND HEMATOCRIT LEVELS OF BLOOD STORAGE IN DR. WAHIDIN SUDIROHUSODO GENERAL HOSPITAL BLOOD BANK
Authors: Wahyu Rysna , Nurulita Asvin , Muhidin Rachmawati
Published: October 2019

The components of Packed Red Cells (PRC) are transfused to patients in order to repair oxygen transportation to tissues. The blood is stored at 2-6oC to delay red blood cells metabolism during storage. Red blood cells undergo structural and functional changes biochemically which affect their viability and function. This is a prospective cohort study with time series design. Samples were taken from fresh blood PRC which were moved to transfer bag for approximately 20 mL, then stored in the refrigerator. Lactic acid and hematocrit levels were assessed with spectrophotometry and flow cytometry methods on day 1, day 4, and day 8 of storage in the Dr. Wahidin Sudirohusodo General Hospital Blood Bank. Statistical tests used were Friedman and Wilcoxon. Statistical results are significant if p < 0.05. Total samples were 15 fresh blood PRC. Friedman statistical test showed a significant difference in lactic level (p < 0.001) and hematocrit level (p=0.012) on day 1, day 4, and day 8 of storage. Wilcoxon test showed significantly higher lactic level between day 4 and day 1 (p < 0.01); day 8 and day 1 (p < 0.01); day 4 and day 1 of storage (p < 0.01). Hematocrit level between day 4 and day 1 (p < 0.05); day 8 and day 1 (p < 0.05) were significantly higher; day 8 and day 4 of storage (p > 0.05) showed insignificant difference. Results showed that lactic and hematocrit levels of PRC stored blood were increased according to storage duration. Packed red cells blood is recommended to be given in < 6 days for lower acidosis risk. Further studies are also recommended with a shorter interval of assessment and a bigger sample size.
ANALYTICAL PERFORMANCE OF PROCALCITONIN LEVEL BETWEEN CHEMILUMINESCENCE AND QUANTITATIVE IMMUNOCHROMATOGRAPHY METHODS IN SEPSIS PATIENTS
Authors: Mario Mario , Tambunan Betty Agustina , Hardiono Hardiono
Published: October 2019

Sepsis is a public health problem in many countries. The latest diagnosis criteria are quick Sequential Organ Failure Assessment  (qSOFA). Procalcitonin (PCT) could be used to aid the diagnosis of sepsis. The aim of this study was to determine the diagnostic value of PCT between CLIA and quantitative immunochromatography tests in sepsis patients. Samples were obtained from the resuscitation room, intensive observation room, and Intensive Care Unit (ICU) Dr. Soetomo General Hospital between December 2017-February 2018. One hundred and one subjects were examined and classified into sepsis group (n=71) and healthy group (n=30), based on qSOFA and SIRS criteria. Procalcitonin test with CLIA and quantitative immunochromatography method were performed in all subjects, followed by culture examination in sepsis group using PhoenixTM 100. The diagnostic value of the two methods was analyzed by 2x2 table with a Confidence Interval (CI) of 95%. There were significant differences of procalcitonin level between CLIA and quantitative immunochromatography method in the sepsis group (p=0.009) and in the healthy group (p=0.002). The diagnostic value of procalcitonin level by CLIA method with a cut-off value â‰¥ 0.27 ng/mL (AUC=0.839, sensitivity (Sn)=74.6%, specificity (Sp)=86.7%, Positive Predictive Value (PPV)=93%, Negative Predictive Value (NPV)=59.1%) had the same sensitivity but higher specificity, PPV, and NPV rather than by quantitative immunochromatography method (AUC=0.786, Sn=74.6%, Sp=66.7%, PPV=84.1%, NPV=52.6%). Procalcitonin examination with CLIA had a better diagnostic value than quantitative immuno-chromatography method.
PLATELET LEUCOCYTE AGGREGATES ANALYSIS IN LEUCODEPLETED AND NON-LEUCODEPLETED PLATELET CONCENTRATES
Authors: Triyono Teguh , Bahraen Raehanul
Published: October 2019

Activated platelet could initiate aggregation and linkage with nearby leucocytes to form Platelet-Leucocyte Aggregates (PLA). Leucodepletion procedure could remove leucocyte and separate it from the other blood components therefore minimalizing the probability of PLA formation. We analyze percentage difference of PLA in leucodepleted and non-leucodepleted platelet concentrate. Dual expression of CD41 and CD45 was determined by flowcytometry method representing the value of PLA, PLA percentage of each group was calculated and analyzed with statistical software SPSS 22. Mean percentage value of PLA in leucodepleted group was 63.05 ±19.86, meanwhile in non-leucodepleted group was 64.61 ±17.27. We found that the percentage of PLA in nonleucodepleted group is higher than leucodepleted although the difference is not statistically significant.
TENSILE STRENGTH AND FIBRINOGEN YIELD IN FIBRIN GLUE PREPARATIVES WITH AND WITHOUT FREEZE-DRYING METHOD
Authors: Margalin Brilliant , Edijanto S. P. , Notopuro Paulus B.
Published: October 2019

Fibrin glue is a useful biological product to stop bleeding, adhesive tissue and accelerate wound healing. Preparation of Fibrin Glue requires fibrinogen and thrombin components. The routine cryoprecipitation method performed at the Blood Bank can be used to improve the quality of the fibrinogen component. The Freeze Drying process can increase the retention time of plasma products at room temperature. Yield Fibrinogen and Tensile Strength is a quantitative and qualitative parameter of preparation quality of fibrin glue. This study focused on finding differences between Tensile Strength and Yield Fibrinogen on fibrin glue preparative by cryoprecipitate with and without freeze drying methods.This study is in vitro laboratory experiments design by comparing the Yield Fibrinogen and Tensile Strength of fibrin glue preparation from cryoprecipitic plasma with and without freeze dried process. The results were analyzed comparatively using paired T test.The plasma fibrinogen content of the sample was 237.66 ± 67.10 mg / dL. The fibrinogen content of the cryoprecipitate component without freeze drying process was 327.74 ± 103.42 mg / dL with a yield fibrinogen of 1.38 ± 0.25. The fibrinogen content of the cryoprecipitate component with freeze drying process was 251.20 ± 103.91 mg / dL with yield fibrinogen 1.04 ± 0.25. Tensile strength of fibrin glue from cryoprecipitate without freeze drying process was found to average 0.52 ± 0.18. Tensile strength of fibrin glue from cryoprecipitate with freeze drying process was found to average 0.33 ± 0.12. There was a significant difference between yield fibrinogen and tensile strength of fibrin glue preparation of cryoprecipitation method with and without freeze dried process.There is a significant difference on yields fibrinogen and tensile strength in the preparation of fibrin glue by the freeze drying process which is probably due to changes in the structure and function of fibrinogen proteins.
D-DIMER IN HEMODIALYSIS PATIENTS RECEIVING CONTINUOUS AND INTERMITTENT HEPARIN
Authors: Fritiwi Derry Heppy , Lubis Harun Rasyid , Aman Adi Koesoema , Hariman Herman
Published: October 2019

Haemodialysis is the most widely used kidney replacement therapy in Indonesia and in the world, but the procedure may trigger development on thrombogenesis. Doe to this reason, anticoagulant heparin is given during haemodialysis to prevent the development of thrombus. However, haemostasis monitoring is essential to predict the possibility of heparin induced bleeding. The use of heparin in general needs a machine to regulate continuous heparin administration, nonetheless not all hospitals have that instruments and for this reasons some centre use intermittent heparin injection. The aim of this study is to investigate whether  intermittent heparin is as effective as continuous heparin to prevent thrombus formation as well as to prevent bleeding and predict the survival outcome. Patient divided in to two grup from intermittent heparin and continuous heparin in total 50 patient were participated. Platelet count, PT, APTT, TT, fibrinogen, and D-dimer were investigated. The result demonstrates that platelet count, PT, APTT, TT, fibrinogen, and D-dimer were not significantly differed between the groups receiving intermittent and continuous heparin (p >0.05). When the test is compared between intermittent and continuous heparin in pre and post haemodialysis it is clear that there is significant increases in APTT and fibrinogen both in the intermittent and continuous heparin, but D-dimer is increased in continuous heparin only during post haemodialysis. There is no difference in the 1-year survival outcome between intermittent and continuous heparin. In conclusion, intermittent heparin produces less D-dimer increase compared to continuous heparin but it is as effective as continuous heparin. Intermittent heparin may be used as the alternative choice when continuous syringe driver machine is not available.
THE DIFFERENCE LEVEL OF MYELOPEROXIDASE IN PLATELET CONCENTRATE BASED ON PREPARATION METHOD AND STORAGE DURATION
Authors: Anshori Fuad , Triyono Teguh , Ratnaningsih Tri
Published: October 2019

The thrombocyte concentrate (TC) preparation process through its storage affects the platelets contained inside. The contaminating leukocytes in TC is an important factor implicated in storage lesion on TC during storage. Leukodepletion is a method to reduce contaminant leukocytes. Myeloperoxidase (MPO) is an enzyme produced by polymorphonuclear cells that have the potential to change structure and function of platelets when there is interaction between them during storage. The aim of this study is assessing the difference in myeloperoxidase level of TC based on its preparation method (leukodepleted and non-leukodepleted) and time storage. A cross-sectional observational study was conducted at the Blood Transfusion Services Unit, Dr. Sardjito hospital, Yogyakarta from April to December 2014. Thrombocyte Concentrate products was grouped based on storage time (â‰¤ and >72 hours) and preparation method (leukodepleted and non-leukodepleted), their MPO was then measured. Mean difference in each group was analyzed using ANOVA test and post hoc test with statistical significance level of p < 0.05. There were 64 eligible subjects, consisted of 29 leukodepleted TCs and 35 non-leukodepleted TCs, based on their storage time, 31 TCs had â‰¤72 hours storage  time and the other 33 TCs > 72 hours. There were significantly lower median MPO level in â‰¤72 hours TCs than > 72 hours in non-leukodepleted TC group (13.23 ± 6.47 ng/mL vs 15.58 ± 7.82 ng/mL; p = 0.017). In TC group with more than 72 hours storage time, median MPO level in non-leukodepleted was significantly higher than leukodepleted TC (15.58 ± 7.82 ng/mL vs. 11.11 ± 3.97 ng/mL; p = 0,001). Myeloperoxidase level was lower in non-leukodepleted TC group with â‰¤ 72 hours than > 72 hours storage time. Furthermore, the MPO level was higher in leukodepleted TC than non-leukodepleted TC in > 72 hours storage time.
CORRELATION OF PROCALSITONIN LEVEL WITH SEPSIS DEGREES BASED ON SOFA SCORE
Authors: Novita Citra , Maat Soeprapto , Tambunan Betty Agustina
Published: October 2019

Background. Sepsis is defined as a life-threatening organ dysfunction condition caused by dysregulation of host response towards infection. Sepsis is one of the leading causes of death in medical emergency. A recent study revealed 18 millions of sepsis occur annually with a mortality rate of 30%, so early diagnosis in assessing sepsis severity is necessary as a guide for early and specific therapy. Organ dysfunction in sepsis patients is associated with high mortality, assessed by Sequential Organ Failure Assessment (SOFA) criteria. Procalcitonin is widely used for diagnosing, monitoring, and prognosis sepsis.Aim This study aimed to analyze the correlation of procalcitonin level with sepsis severity based on SOFA score.  Method. This was an observational cross-sectional study. Samples were collected from December 2017-February 2018 of 72 patients. Each patient was calculated by SOFA score and underwent procalcitonin examination using an immunochromatography method by RAMP. Results. Samples from 72 patients who met the criteria, were analyzed consisting of 37 mailes(51.4%) and 35 females(48.6%), aged 23-77 years, with mean±SD 47.4±14.02 years. The range of SOFA score was 0-16 with mean±SD 6.47±3.61, while procalcitonin levels 0.20-200 ng/mL mean±SD 21.03±14.63 ng/mL. There was a significant correlation between procalcitonin level and SOFA score (r=0.752;p<0.0001).Discussion. This suggests that procalcitonin may illustrate the severity of sepsis patients. The higher the procalcitonin, the more severe the sepsis.Conclusions and recommendations. SOFA score and procalcitonin examinations should be performed routinely in patients with sepsis to assess prognosis (severity) for earlier pretreatment so that the mortality rate can be lowered.
ANALYSIS OF SOLUBLE FIBRIN MONOMER AS DIAGNOSTIC MARKER FOR ACUTE MYOCARDIAL INFARCTION AND ITS CORRELATION WITH CARDIAC TROPONIN I
Authors: Arthamin Maimun Zulhaidah , Parmadi Lydiana , Djatmiko Dwi Priyadi , Lawanto Elvin Richela
Published: October 2019

Background. The diagnosis of non-ST-segment elevation myocardial infarction (NSTEMI) is required early and accurate to avoid missing diagnosis and improve the rule out of AMI patients. There is a relationship between AMI and the state of hypercoagulation and/or thrombosis process. sFM is a protrombotic marker that is found to be associated with early AMI incidence compared to cTnI that increases after mionecrosis. The aim of this study is to determine that sFM can be used as biomarker for AMI and the correlation between sFM and cTnI.Methods. A cross-sectional analytic observational study was conducted among 23 AMI patients and 27 healthy controls. AMI were established using clinical, ECG and laboratory findings. sFM levels were measured with Stago Compact Max analyzer. Statistical analysis was performed using the Spearman's correlation coefficient, ROC curve analysis, and 2x2 contingency table.Results. A significant correlation were found between the sFM and the cTnI (r=0.422, p<0.05). With a sFM cutoff level of 2.56 µg/mL, AMI could be diagnosed with sensitivity and specificity of 82.6% and 40.7%, respectively (AUC=0,638).Discussion. sFM is a new biomarker for systemic thrombus events, both cardiac and non-cardiac.Conclusions and Suggestions. sFM can be considered as an parameter of AMI. Similar studies with cohort method involving large number may be needed in the future study.
In-Between Images: Where is the Ground?
Authors: Thoma Andrea
Published: October 2019

Joan Jonas’s large survey exhibition at Tate Modern (2018) highlighted the contemporary relevance of this pioneer of performance art in her juxtapositions of analogue and virtual methods. Her process often relies on a ground or stage where physical remnants of her performances are tangible. Drawing from these insights and exploring figure-ground relations through a selection of works by various artists and filmmakers, this article aims to challenge Hito Steyerl’s polemic that we might not need a ground within contemporary virtual image worlds. The consideration of case studies will be informed by philosophical reflections as to the relevance and scope of the idea of ground within the post-digital era.
Intermediality of Screens in Post-Media Assemblages
Authors: Maithani Charu
Published: October 2019

In contemporary artworks of so-called post-media assemblage, screens can be argued to emphasize, interconnect and rearticulate relationships between various parts in various modalities of image-making and display. They can be understood to produce gesturality that maintains conditions of mediality, which is the sustenance of relations between different parts of the media ensemble. This paper is an attempt to understand screens by analysing the gesturality that they propagate and not just facilitate. For this purpose, the paper interrogates the intermediality of screens in contemporary media arts that rely on this gesturality. By closely analysing contemporary media art installations such as Solar Reserve (Tonopah, Nevada) (John Gerrard, 2014) and Shadow 3 (Shilpa Gupta, 2007), this paper elaborates a concept of intermediality as an unfixed state and describes in-betweenness as enabling an openness to continuously form, unform and deform relations with different entities, thereby producing a gestural modality.
Television and Video Screens in Filmic Narratives: Medium Specificity, Noise and Frame-Work
Authors: Virginás Andrea
Published: October 2019

The paper discusses pertinent aspects of the screen as a device of framing and re-ordering. Television and video screens introduced in filmic diegesis are attributed three main functions (spatial, temporal, and topical re-ordering) and are related to the relationships Gerard Genette establishes between first-order narrative and metadiegetic levels (1987), as well as to Lars Elleström’s extracommunicational and intracommunicational actual and virtual spheres (2018). The visibility through noise of the televisual and of the video media is theorized based on Sybille Krämer’s media theory (2015) and three pre-digital arthouse films: Videodrome (David Cronenberg, 1984), Irma Vep (Olivier Assayas, 1996), and Lost Highway (David Lynch, 1997).1
Possibility Analysis of Using Acoustic Emission for Monitoring Technical Condition of Compressed Air Installation of 3AL25/30 Engine
Authors: Dudzik Krzysztof , Charchalis Adam
Published: October 2019

This paper presents the methodology and research results of monitoring of compressed air starting system of 3AL25/30 engine placed in Maritime Engineering Faculty of Gdynia Maritime University. Research was carried out using a set of acoustic emission Vallen System. Analysis of recorded parameters revealed leakage in the installation – damage of one of the valves. The test results indicate that the AE method can be useful for monitoring the technical condition of pressure systems of engines and devices in a ship's engine room during normal operation as an on-line system.
Measurement and Diagnostic System for Marine Engines
Authors: Charchalis Adam
Published: October 2019

The Scheduled Maintenance System allows ship-owners and operators to plan, carry out and document the maintenance and repair of equipment and mechanisms on board the ship at intervals in accordance with the class requirements imposed by the Classification Societies and the manufacturer of the equipment. In order to develop the research capabilities of the Faculty of Marine Engineering of Gdynia Maritime University, a Measurement and Diagnostic System has been developed to assess the technical condition of machinery and equipment in operation on board the ship. Modernization of measuring equipment, significantly expanded the research capabilities, which resulted in increasing the scope, improving quality, and speeding up the research and development work in the field of safety of operation and diagnostics of engine rooms and ship operation.
Designation of the Troposphere Radio Refractivity for the Area of the Military Aerodrome in Dęblin
Authors: Kirschenstein Małgorzata , Krasuski Kamil
Published: October 2019

The radio refractivity is one of major parameters in troposphere monitoring over a selected military aerodrome. The paper makes an in-depth analysis and description of the results of radio refractivity of the troposphere zone. The radio refractivity of the troposphere zone was estimated for the area of the military aerodrome EPDE in Dęblin, Poland. The radio refractivity of the troposphere zone was calculated using empirical troposphere models for the GNSS satellite technique as well as real meteorological data from the SYNOP message. In the paper, the authors demonstrate the results of wet, hydrostatic and total radio refractivity of the troposphere zone for EPDE military aerodrome. The SA and UNB3m models were applied in numerical computations of troposphere refractivity in an annual period.
The Risk of Hazards Analysis in Unmanned Aerial Vehicle Flight
Authors: Maciejewska Marta , Kardach Monika , Galant Marta , Fuć Paweł
Published: October 2019

Along with development Commercial Air Transport were observed increase popularity of general aviation, include RPAS (Remotely Piloted Aircraft System). In manned air transport through years created a lot of standards and regulations. For still developing RPAS not created any official rules came from ICAO. This article is a trial to arranged available and commonly using methods risk management hazard to RPAS area. Prepared a list of 72 questions about the hazard sources occurring in the analyzed area. The answers allow to identify 45 sources of hazard. Based on them, 18 hazards were identified. Guided by the ideas and good practices of manned aviation, it is necessary to harmonize legal regulations concerning safety management in unmanned flights.
Reliability Analysis of Critical Kinematic Pair of the RD-33 Engine
Authors: Bogucki Karol
Published: October 2019

The article addressed the technological problem occurring in the RD-33 turbine engine on the kinematic pair between the accessory gearbox (AGB) and fuel regulator pump HP-59A (Polish: NR-59A). In the beginning, examples of operational problems were described. Then, the power balance for the accessory gearbox and strength calculations of gear and splines of a critical pair were presented. It was demonstrated that gear made from an original material complies with strength criteria and the observed operational problems with splines are created by other factors.
The Concept of Nontraditional Student
Authors: Daiva Treinienė
Published: October 2019

Nontraditional student is understood as one of the older students enrolled in formal or informal studies. In the literature, there is no detailed generalisation of nontraditional student. This article aims to reveal the concept of this particular group of students. Analysing the definition of nontraditional students, researchers identify the main criteria that allow to provide a more comprehensive concept of the nontraditional student. The main one is the age of these atypical students coming to study at the university, their selected form of studies, adult social roles status characteristics, such as family, parenting and financial independence as well as the nature of work. The described features of the nontraditional student demonstrate how the unconventional nontraditional student is different from the traditional one, which features are characteristic for them and how they reflect the nontraditional student’s maturity and experience in comparison with younger, traditional students. Key features - independence, internal motivation, experience, responsibility, determination. They allow nontraditional students to pursue their life goals, learn and move towards their set goals. University student identity is determined on the basis of the three positions: on the age suitability by social norms, the learning outcomes incorporated with age, on the creation of student’s ideal image. There are four students’ biographical profiles distinguished: wandering type, seeking a degree, intergrative and emancipatory type. They allow to see the biographical origin of nontraditional students, their social status as well as educational features. Biographical profiles presented allow to comprise the nontraditional student’s portrait of different countries. Traditional and nontraditional students’ learning differences are revealed by analysing their need for knowledge, independence, experience, skill to learn, orientation and motivation aspects. To sum up, the analysis of the scientific literature can formulate the concept of the nontraditional student. Nontraditional student refers to the category of 20-65 years of age who enrolls into higher education studies in a nontraditional way, is financially independent, with several social roles of life, studying full-time or part-time, and working full-time or part-time, or not working at all.
PENERAPAN MODEL PEMBELAJARAN KOOPERATIF TIPE NHT UNTUK MENINGKATKAN HASIL BELAJAR SISWA PADA MATERI PECAHAN DI KELAS V SDN 2 BANDA ACEH
Authors: Vitoria Linda , Akhwilla Vivi Vanda
Published: October 2019

Numbered Heads Together (NHT) is a teaching approach that promotes students' involvement in group discussion. This article reports a classroom action research conducted to improve students’ learning acievement in fractions at Grade V SDN 2 Banda Aceh. The participants were students of Class VA which consisted of 34 students, 22 boys and 12 girls. The research was conducted in 2 cycles, each consisted of 4 classroom meetings. The procedure of the research involved four stages: planning, action, observation, and reflection. The research questions covered students’ learning activities, students’ learning outcomes, and students’ responses on the implementation of NHT in the teaching of fractions. Results show that there were improvements in students’ learning activity from the average score of 2,57 in cycle 1 to 3,04 in cycle 2. Students’ learning outcomes improved from the average score of 66,30 in cycle 1 to 75,38 in cycle 2. Students’ responses in cycle 1 was 82,35% positive and increased to 88,24% in cycle 2. These results imply that the implementation of NHT is beneficial for students’ learning.