bluuebunny/crossref_metadata_2025 huggingface dataset:
Oxidative Carbonylation of Methanol to Dimethyl Carbonate in Ionic Liquid 1-Butyl-3-Methylimidazolium Hexafluorophosphate
Authors: Jiang Tao , Han Buxing , Zhao Guoying , Chang Yanhong , Gao Liang , Zhang Jianmin , Yang Guanying
Published: December 2009

The synthesis of dimethyl carbonate (DMC) by oxidative carbonylation of methanol with PdCl2 as a catalyst was investigated in the room temperature ionic liquid 1-butyl-3-methylimidazolium hexafluorophosphate ([bmim][PF6]). The products were recovered in situ using supercritical carbon dioxide. Enhanced selectivity of DMC over this catalyst was observed in the synthesis in [bmim][PF6] compared with the situation without the ionic liquid (IL). The mixture of catalyst and [bmim][PF6] could be recycled.
An Efficient Method for the Synthesis of β-Dicarbonyl Enones Using Polymer-Supported N, N-Diethylbenzeneselenenamide
Authors: Sheng Shou-Ri , Wei-Zhou  , Liu Xiao-Ling
Published: December 2009

A novel polystyrene-supported N, N-diethylbenzeneselenenamide reagent has been prepared. Reaction of the resin with β-formylcycloanones and subsequent oxidative deselenation afforded β-dicarbonyl enones in good yields and high purities.
Synthesis of Four Novel Benzimidazole Derivatives Mediated by Manganous Acetate – Permanganate Mixture
Authors: Chattopadhyay Shyamal K. , Mitra Kamala , Biswas Subhendu , Lucas Collin R. , Adhikary Bibhutosh
Published: December 2009

The synthesis is described of four novel benzimidazole derivatives from substituted N-phenyl pyridine-2-aldimine Schiff bases mediated by manganous acetate – potassium permanganate mixture.
The Baylis-Hillman Reactions of Aldehydes with Methyl Vinyl Ketone in the Presence of Imidazole, Binol and Silica Gel
Authors: Shi Min , Jiang Yuan
Published: December 2009

In the Baylis–Hillman reaction of aldehydes with methyl vinyl ketone, we found that, in the presence of a stoichiometric amount of binol and silica gel (SiO2), a weak Lewis base such as imidazole can promote the reaction to give the normal Baylis–Hillman adduct under good yields under heterogeneous reaction conditions.
Hypervalent Iodine in Synthesis 74: Synthesis and Reactivity of New Functionalised Alkenyliodonium Salts1
Authors: Zhang Pengfei , Chen Zhenchu
Published: December 2009

β-Amino substituted α,β-unsaturated ketones react with [hydroxy(tosyloxy)iodo]benzene to afford the corresponding alkenyl(phenyl)iodonium tosylates; these new α-acyl-β-aminoalkenyl(phenyl)iodonium tosylates offer an easy access to highly functionalised alkenes upon reaction with verious nucleophiles
Regiospecific Synthesis of Carboxylated and Simple α-Tetralones with Homophthalates and Various Acrylates by a Simple Condensation Method
Authors: Roy H. N. , Rahman A. F. M. M. , Islam M. A.
Published: December 2009

Various carboxylated enols (3) have been prepared by taking advantage of simple condensation reactions of various homophthalates (1) with different acrylates (2), and these enols under heating with two different solvents (DMF and DMSO), afforded ten specific α-tetralones in good to moderate yields using NaCl as a catalyst.
Novel and Efficient Solid-Phase Synthesis of 4,6-Disubstituted 4,5-Dihydro-3(2H)-Pyridazinones
Authors: Tang Jing , Huang Xian
Published: December 2009

The resin-bound 5-monosubstituted cyclic malonic ester 3 was generated and reacted with an α–bromoketone to give the corresponding 5,5-disubstituted cyclic malonic ester resin (4). Subsequent reaction with hydrazine resulted in cyclisation with concomitant cleavage from the polymeric support to release the final products, 4,6-disubstituted 4,5-dihydro-3(2 H)-pyridazinones, in good yield and high purity.
Saligenin Derivative Borocryptands: Synthesis and Structural Analysis of New Type Lithium Borocryptate
Authors: Toğrul M. , Sünkür M. , Kaynak F. B. , Hosgören H. , Özbey S.
Published: December 2009

A new lithium receptor based on the combination of the [11] macrocyclic core and two 4- tert-butyl saligenin units was designed and prepared.
Medium-Sized Cyclophanes. Part 66.1 Through-Space Electronic Interactions on Acylation of 8,16-Disubstituted [2.2]Metacyclophanes
Authors: Yamato Takehiko , Okabe Ryo , Shigekuni Mitsuaki , Furukawa Tsuyoshi
Published: December 2009

Depending on the substituents at the 5-position of 8,16-dimethyl[2.2]metacyclophanes different reactivities to acylation at the 13-position were observed due to the through-space electronic interaction with the other benzene ring.
The Reaction between Tert-Butyl Isocyanide and Acetylenic Esters in Presence of 2-Thenoyltrifluoroacetone: A Synthesis of Highly Functionalised 4H-Pyrans
Authors: Baharfar Robabeh , Hosseini Javad
Published: December 2009

Tert-butyl isocyanide reacts with dialkyl acetylenedicarboxylates in the presence of 2-thenoyltrifluoroacetone to yield 4 H-pyran derivatives in good yields.
Intramolecular Wittig Reactions. A New Synthesis of Coumarins and 2-Quinolones
Authors: Desai Vidya G. , Shet Jyoti B. , Tilve Santosh G. , Mali Raghao S.
Published: December 2009

o-Hydroxybenzaldehydes (1a-d) on reaction with chloroacetyl chloride in presence of pyridine followed by addition of triphenyl phosphine and base gave coumarins (2a-d). A similar sequence of reactions on o-aminoaceto-phenone/benzophenone (1e-f) and methyl anthranilate (1g) gave the corresponding 2-quinolones (2e-g).
Syntheses of 1-Allyl-6-(Arylamino)Methyl-7-Methyl-3-Phenylpteridine-2,4-Dione, a Methanopterin Analogue
Authors: Tada Masaru , Wada Momoko
Published: December 2009

The nucleophilic substitution of 2,3-dicyanopyrazine (1) with allylamine is useful for the construction of pteridine ring. A methanopterin analogue, 1-allyl-6-(mesitylamino)methyl-7-methy-3-phenylpteridine (12), was synthesised by this method from 2,3-dicyano-5-hydroxymethyl-6-methylpyrazine (5) deriving from 2,3-dicyanopyrazine (1).
Micellar Effects on the Reaction of Cr(VI) Oxidation of Hexitols in the Presence and Absence of Picolinic Acid in Aqueous Acid Media
Authors: Saha Bidyut , Das Mahua , Das Asim K.
Published: December 2009

In aqueous acidic media, picolinic acid (PA) promoted CrVI-oxidation of the hexitols to the respective aldohexoses goes on, along with a slower uncatalysed path; the anionic surfactant (SDS) accelerates the process while the cationic surfactant (CPC) retards the reaction.
Epoxidation of Terminal Olefins by Oxygen Catalysed by a Mixture of Manganese and Cobalt Salts of P–Aminobenzoic Acid Supported on Silica Gel
Authors: Hashemi Mohammed M , Khoshabro Daruoosh Keshavarz
Published: December 2009

A mixture of cobalt and manganese salts of p-aminobenzoic acid supported on silica gel catalyses the epoxidation of terminal olefins to the corresponding 1,2-epoxy compounds in the presence of oxygen.
Synthesis of 2-Arylimidazo[1,2-a]Pyrimidines by the Chichibabin Synthesis in Ionic Liquids
Authors: Xu Danqian , Liu Baoyou , Zheng Mei
Published: December 2009

A series of 2-arylimidazo[1,2- a]pyrimidines has been synthesised in excellent yields by the Chichibabin synthesis in room temperature ionic liquids.
Selective Synthesis of Novel Biimidazole Derivatives, Bis-Biimidazole and Tri-Biimidazole
Authors: Xiao Rong , Yu Hua , Gao Ge , Xie Ru-Gang
Published: December 2009

The 2,2′-biimidazole derivatives containing imidazole or benzimidazole moieties, bis-biimidazole and tri-biimidazole have been obtained by selective N-alkylation.
An Efficient Microwave-Assisted One-Pot Conversion of Carboxylic Acids into Hydrazides
Authors: Peng Yanqing , Song Gonghua
Published: December 2009

A microwave-assisted protocol was developed to prepare hydrazides from corresponding carboxylic acids in good yields through transacylation with acethydrazide.
The Synthesis and X-Ray Crystal Structure of 9-Carboxyhexahydro-7-Methoxy-4a,7-Ethano-Benzopyran-5-En-1-One
Authors: Williams Craig M. , Bernhardt Paul V. , Wiedemann Stefan , Barden Michael C.
Published: December 2009

9-Carboxyhexahydro-7-methoxy-4a,7-ethano-benzopyran-5-en-1-one (1) was prepared and examined by X-ray crystallography to probe its potential as a new peptide scaffold/template. The crystal structure of the anhydride precursor 7-(2-acetoxyethyl)-4-methoxy-3a,4,7,7a-tetrahydro-4,7-ethanoisobenzofuran-1,3-dione (6) is also reported.
The Preparation of Novel L-Iso-Glutamine Derivatives as Potential Antitumor Agents
Authors: Wang Jun-li , Xu Wen-fang
Published: December 2009

A series of novel L- iso-glutamine derivatives were prepared by condensing of compound 4 with various amino acid methyl esters. These compounds have not been reported in literature, and their chemical structures were confirmed by ESI-MS, IR and NMR.
Synthesis and Characterisations for the Mononuclear Complex of Trans-Bis(2-Benzamido)Oxazoline Copper (II)
Authors: Zhang You-Ming , Xian Liang , Wei Tai-Bao , Yu Kai-Bei
Published: December 2009

The title complex, was synthesised by the reaction of N-benzoyl- N′-(2-hydroxyethyl)thiourea with cupric chloride in ethanol solution. Desulfurisation of the hydroxyethylthiourea forms the oxazoline ligand.
Studies into the Synthesis of Azolopyrrolidinobenzodiazepinones and Related Compounds. Oxidative Cyclisations, Oxidative Fragmentations and Oxidative Rearrangements in the Reactions of Azolylmethyl-N-Phenyl-Lactams and Related Compounds with Cerium (IV) Ammonium Nitrate
Authors: Bertha Ferenc , Giang Le Thanh , Fetter József , Kajtár-Peredy Mária , Lempert Károly , Nagy Ildikó , Czira Gábor
Published: December 2009

Depending on the nature of the bridge connecting the two hetero rings of the substrates of types 4, 7, 11 and 12 studied, the substrates are attacked by CAN at different sites and, therefore, afford different types of oxidation products.
The Synthesis of Some Novel Substituted Benzochromene Derivatives
Authors: Büyükkıdan Bülent , Ceylan Mustafa
Published: December 2009

Quinonemethides generated from 6-bromo-2-[( N,N-dibenzylamino)methyl]naphthalen-1-ol (5) and 1-( N,N-dimethylaminomethyl)naphthalen-2-ol (1) react in inverse-electron-demand Diels-Alder reactions with substituted styrenes, N-vinylimidazole, and butyl vinyl ether, to afford the expected dihydro-benzo[ h] and -benzo[ f] chromenes in 36–53% yields.
Kinetics of Edta-Catalysed Oxidation of Some Cycloalkanones by Pyridinium Chlorochromate
Authors: Meenakshisundaram Subbiah , Markkandan Ramakrishnan
Published: December 2009

Cr(IV)edta–cycloalkanone ternary complex decomposes by slow oxidation to the α-ketol followed by fast oxidation to the dione.
Preparation of Acyl Azides from Aromatic Carboxylic Acids Using Triphosgene in Ionic Liquids
Authors: Bao Weiliang , Wang Qiang
Published: December 2009

Acyl azides are obtained in high yields from aromatic carboxylic acids and sodium azide at room temperature in ionic liquids using triphosgene as a synthetic auxiliary under mild reaction conditions and with a short reaction time.
A Useful 8-Hydroxyquinoline Synthon
Authors: Cross Jason P. , Sammes Peter G.
Published: December 2009

The preparation of 2-bromomethyl-8-(2,2-dimethylpropanoyloxyquinoline) is described and its use as a synthon for the incorporation of 8-hydroxyquinoline units into aza-crowns is exemplified.
New Tetrapyrazolic Macrocycle. Synthesis and Cation Binding Properties
Authors: Radi Smaail , Ramdani Abdelkrim , Lekchiri Yahya , Morcellet Michel , Crini Grégorio , Janus Ludovic
Published: December 2009

The synthesis of a new tetrapyrazolic macrocyclic structure with a functionalised arm is described. The complexing properties of this new compound towards heavy metal ions (Hg2+, Cd2+, Pb2+) and alkaline metal ions (Ca2+, Cs+, K+, Na+, Li+) was studied by a liquid–liquid extraction process and the extracted cation percentage was determined by atomic absorption measurements and UV spectroscopy. This ligand is able to complex each of these metal ions with yields depending on the nature of the metal.
Hypervalent Iodine in Synthesis 92. A Facile Synthesis of 3-Substituted-5,6-Dihydroimidazo[2,1-b]Thiazoles by Cyclocondensation of Alkynyl(Phenyl)Iodonium Salts and Imidazolidine-2-Thione
Authors: Liu Zhi , Chen Zhen-Chu , Zheng Qin-Guo
Published: December 2009

A simple method for the synthesis of 3-substituted 5,6-dihydroimidazo[2,1- b]thiazoles is achieved by cyclocondensation of alkynyl(phenyl)iodonium salts with imidazolidine-2-thione.
Reaction of 7-Aza-Norbornadiene and [W(CO)4(NCMe)2]
Authors: Ding Mei-Fang , Lin Shaw-Tao , Chow Tashin J.
Published: December 2009

Three ring-opening products, 3-( p-toluenesulfonyl)-N-methoxy-carbonylpyrrole, 3-( p-toluenesulfonyl)pyrrole, and phenyl tolyl sulfone, were obtained from the reaction of 7-methoxycarbonyl-2-p-toluenesulfonyl-7-aza-norbornadiene and [W(CO)4(NCMe)2].
A Short and Expeditious Regiospecific Synthesis of Novel Pyrazoles
Authors: Chowdhury S.K. Dutta , Sarkar Mili , Mahalanabis Kumar K.
Published: December 2009

α-Cyano-β-enaminones, obtained by regioselective acylation of β-aminocrotononitrile, are smoothly and regiospecifically converted into substituted pyrazoles in good to excellent yields.
Oxidation of thiols with 1-butyl-4-aza-1-azoniabicyclo[2.2.2]octane dichromate (BABOD) under non-aqueous conditions
Authors: Hajipour A.R , Bagheri Hamid , Ruoho Arnold E.
Published: December 2009

The preparation of 1-butyl-4-aza-1-azoniabicyclo[2.2.2]octane dichromate and the use of this reagent for selective oxidation of aromatic and aliphatic thiols to their corresponding disulfides under non-aqueous conditions is reported
Organic Reactions in Ionic Liquids: An Efficient Method for the Synthesis of Aryl Sulfones by Alkylation of Sodium Arenesulfinates with Alkyl Halides
Authors: Hu Yi , Chen Zhen-Chu , Le Zhang-Gao , Zheng Qin-Guo
Published: December 2009

An ionic liquid based on 1-butyl-3-methylimidazolium tetrafluoroborate (BmimBF4) is used as a reusable reaction medium for the alkylation of sodium arenesulfinates with alkyl halides. This procedure is convenient, efficient and generally gives rise to the S-alkylated product with high selectivity when applied to active halides.
Rapid synthesis of calix[4]resorcinarene-based dendrimers containing salicylideneimine terminal groups
Authors: Ge Yun , Yan Chaoguo
Published: December 2009

Second–generation calix[4]resorcinarene-based dendrimers containing 16 or 24 terminal salicylideneimines were synthesised by divergent method in five steps from the corresponding calix[4]resorcinarenes.
Synthesis of 2,3,4,5-tetrasubstituted pyrroles from aromatic ketoximes using the TiCl4/Et3N reagent system
Authors: Periasamy Mariappan , Srinivas Gadthula , Seenivasaperumal Muthu
Published: December 2009

Aryl alkyl ketoximes react with the TiCl4/Et3N reagent to give 2,3,4,5-tetrasubstituted pyrroles in moderate to good yields (55–81%).
Low-valent titanium induced reductive deprotection of oximes
Authors: Fan Xuesen , Zhang Xinying , Zhang Yongmin
Published: December 2009

An efficient regeneration of carbonyl compounds through low-valent titanium induced reductive deprotection of oximes is described in this paper.
Synthesis of pregnane ketols as metabolic precurs ors of analogues of plant growth regulators
Authors: Rivera Daniel G. , Coll Francisco , León Fredy
Published: December 2009

The synthesis of seven new D-ring functionalised 5α-hydroxylated biosynthetic precursors of brassinosteroid analogues is described.
Triethyl-germanium, -tin and -lead complexes derived from internally functionalised oximes
Authors: Sharma Vinita , Agarwal Sangeeta , Bohra Rakesh , Jain Vimal K.
Published: December 2009

Reactions of triethylmetal(IV) chlorides with sodium salts of internally functionalised oximes in a 1:1 molar ratio in refluxing anhydrous benzene yield [Et3M{ON=C(R)Ar}] [where R = H, Me; M = Ge (1–5), Sn (6,7) or Pb (8–12); Ar = 2-C5H4N, 2-C4H3O or 2-C4H3S]. All these derivatives have been characterised by elemental analysis and IR and NMR [1H, 13C{1H}, 119Sn{1H} and 207Pb{1H}] spectroscopic studies. Absence of any significant shift in the hetero-aryl ring carbon / proton resonances and the presence of chemical shifts at ∼δ110 ppm in 119Sn NMR and at ∼ δ 400 ppm in 207Pb NMR spectra of these derivatives have been interpreted in terms of a tetrahedral geometry around the metal atom.
A synthesis of 10-aryl-2,7-dimethyl-4,5-dioxo-3,6,9- trioxa-3,4,5,6,9, 10-hexahydroanthracene catalysed by KF-alumina
Authors: Feng Youjian , Gao Yuan , Zhu Songlei , Li Tuanjie , Zhang Xiaojing , Tu Shujiang , Shi Daqing
Published: December 2009

A series of 10-aryl-2,7-dimethyl-4,5-dioxo-3,6,9- trioxa-3,4,5,6,9,10-hexaanthracenes were prepared by the reaction of aromatic aldehydes with triacetic acid lactone in ethylene glycol catalysed by KF-alumina.
The biodegradation of the phytotoxic metabolite botrydial by its parent organism, Botrytis cinerea
Authors: Durán-Patrón Rosa , Cantoral Jesús M. , Hernández-Galán Rosario , Hanson James R. , Collado Isidro G.
Published: December 2009

The inhibition of the growth of Botrytis cinerea has been found to be directly proportional to the concentration of its metabolite, botrydial (1). The fungus transforms botrydial (1) to the less active phytotoxins dihydrobotrydial (2), botryenedial (3), and secobotrytrienediol (4). Two main biodegradative pathways of botrydial (1) and the interconversion of the botryane toxins excreted by B. cinerea are proposed.
KAl(SO4)2.12H2O as a recyclable Lewis acid catalyst for synthesis of some new oxindoles in aqueous media
Authors: Azizian Javad , Mohammadi Ali A. , Karimi Ali R. , Mohammadizadeh Mohammad R.
Published: December 2009

Potassium aluminum sulfate (Alum) efficiently catalyses the electrophilic substitution reaction of indole and isatin in aqueous solution at room temperature and under microwave irradiation to afford the new corresponding bis(indol-3-yl)methanes (DIM) and the new corresponding oxindoles.
Two new diterpenoids from Isodon japonica
Authors: Bai Suping , Jin Xiaoling , Yang Li
Published: December 2009

Two new diterpenoids, maoyecrystal J (1) and maoyecrystal K (2), together with five known diterpenoids, effusanin A (3), isodonal (4), isodonoiol (5), rabdosinate (6) and rabdosin B (7) were isolated from Isodon japonica (Burman f.) Hara. The structures of the two new compounds were assigned 1α,6β,7β-trihydroxy-7α,20-epoxy- ent-kaur-11(12),16(17)-dien-15-one (1) and 6β,11α-dihydroxy-16β-methoxymethyl-6,20-epoxy-6,7- seco-ent-kaur-15-one-1α, 7-olide (2) on the basis of HR–MS, 1H, 13C and 2D NMR spectroscopic methods.
1-Aryl-2-chloro-5-methoxy-1H-3-pyrrolecarbaldehyde as Synthons for Fused Heterocycles: Synthesis of Pyrazolo[3,4-d]pyrrolo[2,3-b]pyridine Derivatives
Authors: El-Nabi Hisham A. Abd
Published: December 2009

Pyrazolo[3,4- d]pyrrolo[2,3- b]pyridine derivatives (6a–f) were obtained by oxidation of tosylhydrazones of 2-allylamino-5-methoxypyrrole-3-carbaldehydes (3a–f) with lead tetraacetate. The nitrilimine intermediates (5a–f) underwent intramolecular 1,3-dipolar cycloaddition to yield the tricyclic heterocycles 6a–f in good yields.
6-Aminouracils as precursors for the syntheses of fused di- and tricyclic pyrimidines
Authors: Youssif Shaker
Published: December 2009

The treatment of 1-benzyl-, or 1-methyl-6-chlorouracil (1a,b) with nucleophilic primary amines followed by nitrosation, reduction, formylation and dehydro-cyclisation lead to xanthines 5 and 7. While, the treatment of uracil 8 with aromatic aldehydes 9a–f leads to the formation of dipyrimidinopyridines 10a–f, reaction with formalin and primary amines gives pyrimidopyrimidines 11a–d via double Michael reactions.
A stilbene dimer, andalasin B, from the root trunk of Morus macroura
Authors: Syah Yana M. , Achmad Sjamsul A. , Ghisalberti Emilio L. , Hakim Euis H. , Makmur Lukman , Soekamto Nunuk H.
Published: December 2009

A new stilbene dimer, andalasin B, was isolated from the root trunk of Morus macroura Miq., together with three known compounds, andalasin A, lunularin, oxyresveratrol, and β-resorcylaldehyde.
Copper Chloride/Kieselguhr: An Efficient Catalyst for Oxidation of Thiols to Disulfides by Molecular Oxygen or Air
Authors: Hashemi Mohammed M. , Karimi-Jaberi Zahed , Ghazanfari Dadkhoda
Published: December 2009

Kieselguhr supported copper chloride catalyses the oxidation of thiols to disulfides in the presence of oxygen or air.
Difunctional distannoxanes, XR2SnOSnR2X
Authors: Davies Alwyn G.
Published: December 2009

The difunctional distannoxanes, XR2SnOSnR2X, can be prepared by a number of different routes, and frequently turn up unexpectedly in reactions involving organotin compounds. They show a variety of (usually dimeric) structures, and are mild but effective catalysts for a variety of polar organic reactions. This article gives an overview of their chemistry.
One-pot synthesis of isoxazolines and isoxazoles using soluble polymer-supported aldehyde
Authors: Shang Yongjia , Yuan Lili , Wang Yanguang
Published: December 2009

Liquid-phase synthesis of isoxazoles and isoxazolines through a 1,3-dipolar of nitrile oxides is described. Soluble polymer-supported nitrile oxides generated in situ react with dipolarophiles to afford isoxazoles and isoxazolines in good yields and purity.
Ligand controlled synthesis of mixed-ligand oxovanadium(V) and oxovanadium(IV) complexes
Authors: Ghosh Tapas , Bhattacharya Sharmila , Bandyopadhyay Chandrakanta , Mukherjee Gurunath
Published: December 2009

Reaction of VIVO(acac)2 (where Hacac = acetylacetone) with 2-hydroxybenzylalcohol (H2L) produces [VVO(L)(acac) (H2O)], 1 but the above reaction mixture produces [VVO(L)(hq)(CH3OH)], 2 and [VIVO(HL)(pa)(CH3OH)], 3 in presence of 8-hydroxyquinoline(Hhq) and picolinic acid(Hpa), respectively.
Preparation of aryl allyl ether in the recyclable ionic liquid [bmim]PF6
Authors: Zhou Mei-Yun , Li Yi-Qun
Published: December 2009

The recyclable room temperature ionic liquid [bmim]PF6, namely l-butyl-3-methyl-imidazolium hexafluorophosphate, is used as an alternative solvent to dipolar aprotic solvents for the synthesis of aryl allyl ether by the Williamson method.
X-ray crystal structure of 3β,22-dihydroxy-23,24-dinorchol-4-ene
Authors: Cox Philip J. , Nahar Lutfun , Turner Alan B.
Published: December 2009

The crystal structure of 3β,22-dihydroxy-23,24-dinorchol-4-ene, previously synthesised from 3-oxo-23,24-dinorchol-4-ene-22-al, has been determined by X-ray crystallography.
Syntheses of the novel thiamacrocycles containing the 1,10-phenanthroline unit
Authors: Liu Tian-Fu , Lin Hua-Kuan , Chen Lang-Xing , Zhu Shou-Rong , Wang Zhong-Ming , Su Xun-Cheng , He Xi-Wen
Published: December 2009

The syntheses of three new thiamacrocycles 5, 6 and 7 including the 1,10-phenanthroline unit are described and show high selectivity for Pb2+ and Ag+.
Synthesis of trans-3-carbamoyl-2-(3-pyridyl)-1,2,5,6-tetrahydro-3H-pyrrolo[2,1-a]isoquinolinium chloride by condensation of 2-carbamoyl-methyl-1-methyl-3,4-dihydroisoquinolinium chloride with nicotinaldehyde
Authors: Kleizienė Neringa , Degutytė Rimgaile , Berg Ulf , Šačkus Algirdas
Published: December 2009

Condensation of 2-carbamoylmethyl-1-methyl-3,4-dihydroisoquinolinium chloride with nicotinaldehyde in the presence of a catalytic amount of piperidine affords trans-3-carbamoyl-2-(3-pyridyl)-1,2,5,6-tetrahydro-3 H-pyrrolo[2,1- a]isoquinolinium chloride.0
Synthesis of dinaphtho[2,1-d:1′,2′-g][1,3,2]dioxaphosphocin 8-sulfides
Authors: Kasthuraiah Maddali , Kumar Kanduluru Ananda , Kiran Yarragudi Bathal Reddy , Reddy Cirrunduru Suresh
Published: December 2009

In an efficient two step synthesis of substituted 8-aryloxy/arylthio-16 H-dinaphtho[2,1- d:1′,2′- g][1,3,2] dioxaphosphocin 8-sulfides, dimethylaminopyridine (DMAP) catalyses the preparation of the intermediate monochloride 3 from bis-(2-hydroxy-1-naphthyl)methane (1) and thiophosphoryl chloride. Displacement of the chlorine in 3 with substituted sodium phenoxides or thiophenoxides proceeds nearly quantitatively in toluenetetrahydrofuran at room temperature.
Synthesis of New Anthraquinone and Naphthohomobarrelene Derivatives
Authors: Menzek Abdullah , Kazaz Cavit , Eryiğit Feryat , Cengiz Mustafa
Published: December 2009

Cycloadditions of 1,4-naphthoquinone with cycloheptatriene and its 7-carbomethoxy and 7-cyano derivatives are investigated. The synthesis of new anthraquinone and naphthohomobarrelene derivatives is reported.
Total Synthesis of (-)-Praziquantel: An Anthelmintic Drug
Authors: Ma Chen , Zhang Qian-Feng , Tan Ye-Bang , Wang Long
Published: December 2009

The optically pure (–)-praziquantel was synthesised using phenylethylamine as starting material in 12% overall yield. The key step was achived by a chiral auxiliary mediated Pictet–Spengler reaction.
Preparation and Structural Properties of Thiametacyclophanes Having Pyridine Rings
Authors: Moriguchi Tetsuji , Kamada Kanako , Sakata Kazunori , Tsuge Akihiko
Published: December 2009

Various substituents have been introduced into the inner position of the dithia[3.3]metabenzenopyridinophanes (MPPs) and their conformational are evaluated by variable temperature 1H NMR spectral measurements, IR measurements, computer calculation and X-ray structural analyses.
Synthesis and Characterisation of Mixed Ligand Complexes of Cu(II) Containing Optically Active R-(+)- & S-(–)-1,1′-bi-2-Naphthol (BINOL)
Authors: Patel Mitesh J. , Trivedi Bhavna M.
Published: December 2009

The novel mixed ligand complexes of Cu(II) with optically active R-(+)- / S-(–)-1,1′-bi-2-naphthol and N, N′ – donor bidentate ligands have been synthesised and characterised by elemental analysis and various spectral studies.
Modelling Copper (II) Liquid–Liquid Extraction: The System Acorga M5640-Exxsol D100–CuSO4–H2SO4
Authors: Alguacil Francisco José , Alonso Manuel , López-Delgado Aurora , Navarro Patricio
Published: December 2009

A predictive model, which consists in a set of non-linear mass action and mass balance equations solved by using a taylor-made equation-solving program, is used as a basis to predict experimentally measured distribution coefficients for the Acorga M5640-Exxsol D100–CuSO4–H2SO4 liquid–liquid extraction system at 20°C and aqueous copper concentrations in the range 0.0016–0.0032 mol l−1. The model is also used to obtain the copper loading isotherm at various equilibrium aqueous pH values.
GaI3 Catalysed Nucleophilic Addition of Allyltrimethylsilane to Aldehydes
Authors: Sun Peipei , Xian Yufang , Xiao Yaping
Published: December 2009

In dichloromethane, the nucleophilic addition of allyltrimethylsilane to aldehydes to give the corresponding homoallyl alcohols in good to excellent yields was catalysed effectively by gallium triiodide which was generated in situ by the reaction of gallium metal and iodine.
An Alternative Preparation of Steroidal Δ4-3,6-Diones
Authors: Kiran Ismail , Hanson James R.
Published: December 2009

The oxidation of readily available steroidal 3-chloro-3,5-dienes with chromic acid is shown to give the corresponding 4-ene-3,6-diones.
Synthesis of Diacetals from Aldehydes and Ketones with Pentaerythritol Catalysed by the ZrO2/S2O82- Solid Superacid
Authors: Jin Tongshou , Yang Mina , Wang Xin , Feng Guoliang , Li Tongshuang
Published: December 2009

A manipulatively simple and rapid procedure for the synthesis of diacetals from 2,2-bis(hydroxymethyl)-1, 3-propanediol with aldehydes and ketones in refluxing benzene or toluene using the ZrO2 /S2O82- solid superacid as catalyst in 80–98% yields has been described.
Alkylation of Diphenylamines with Chloroacetonitrile: A New Entry to Phentolamine Analogues
Authors: Parihar J.A. , Dash P. , Kudav D.P.
Published: December 2009

The alkylation of diphenylamines with chloroacetonitrile followed by annulation with ethylenediamine gave 2-imidazoline analogues of phentolamine.
Functionalised 1,2,4-Triazino[5,6-b]indoles
Authors: Hamid Hamida M. Abdel
Published: December 2009

3-Ethoxycarbonylmethylthio-5 H-1,2,4-triazino[5,6- b]indole (2) and 5-ethoxycarbonylmethyl-3-ethoxycarbonyl-methylthio-5 H-1,2,4-triazino[5,6- b]indole (4) have been prepared from 2,5-dihydro-3 H-1,2,4-triazino[5,6- b]indole-3-thione (1). The reaction of 2 and 4 with hydrazine hydrate gave the respective mono- and bishydrazide derivatives 3 and 5. Reaction of the monohydrazide 3 with acetylacetone, various carbonyl compounds and monosaccharides afforded the respective hydrazones 6 and 8–14. Dehydrative cyclization of 6 and 9 with boiling acetic anhydride afforded the pyrazole and 1,3,4-oxadiazoline derivatives 7 and 15, and reaction of 3 with CS2/KOH followed by hydrazinolysis afforded 16.
First Total Synthesis of an Analogue of Montbretyl 12-Methyl Ether
Authors: Zhang Cheng-Lu , Qiu Ye-Hong , Pan Xin-Fu
Published: December 2009

The first total synthesis of the title compound 1 was accomplished starting from α-cyclocitral and benzyl triphenylphosphonium chloride 3 in seven steps via a strategy of AC→ABC. In the synthesis, t-BuOK/ t-BuOH system was utilised for enolisation and the iso-propyl group was introduced in the last step.
An Eco-Friendly Regeneration of Aldehydes Exploiting Ammonium Acetate under Microwave Irradiation
Authors: Mitra Alok Kumar , Karchaudhuri Nilay , De Aparna
Published: December 2009

A number of bisulphite addition products and diacetates are deprotected separately to the corresponding aldehydes exploiting a green reagent, ammonium acetate in solvent-free conditions under microwave irradiation by a rapid, clean, efficient and high yielding method under environmentally benign conditions.
Synthesis, characterisation and crystal structures of asymmetric (Z)-1-[2-(triphenylstannyl)vinyl]-1-indanol and its diphenylbromostannyl derivative
Authors: Zhu Dong-Sheng , Li Xue-Fu , Shao Kui-Zhan , Wang Jing
Published: December 2009

Asymmetric ( Z)-1-[2-(triphenylstannyl)vinyl]-1-indanol 1 and ( Z)-1-[2-(bromo- diphenylstannyl)vinyl]-1-indanol 2 were synthesised and characterised by elemental analysis, 1H NMR, FT–IR spectroscopy and X-ray diffraction analysis.
Enantioselective synthesis and absolute configuration of the natural threo-3-chloro-1-(4-hydroxy-3-methoxyphenyl)propane-1,2-diol
Authors: Wang Qian , He Kan Kan , Li Yun Zhong , Li Da Wei , Li Ying , Hou Zi Jie
Published: December 2009

An efficient method has been developed for the first asymmetric total synthesis of the natural phenylpropanoids, threo-3-chloro-1-(4-hydroxy-3-methoxyphenyl)propane-1,2-diol in eight steps with 36% overall yield. The absolute configuration of the natural product was established using the Sharpless asymmetric dihydroxylation.
The reactions between the aldehyde-anhydride fujenal and ammonia, hydrazine and hydroxylamine
Authors: Hanson James R. , Hitchcock Peter B. , Uyanik Cavit
Published: December 2009

The structures of the products obtained from the reactions of the aldehyde-anhydride fujenal with ammonia, hydrazine and hydroxylamine have been established by X-ray crystallography.
Trace amount of metallic samarium catalysed aroyl substitution reactions of a β-keto ester in air
Authors: Zhang Yandong , Zhang Yongmin
Published: December 2009

Catalysed by a trace amount of metallic samarium, a β-keto ester can react readily with aroyl chlorides to afford 3-oxo-arylpropionic acid esters in good yields. The reaction proceeds in air with toluene as solvent, which is not purified before use.
Comparative orienting effects of the methanesulfonamide group in aromatic nitration
Authors: Hanson James R. , Saberi Hamid
Published: December 2009

The methanesulfonamido group is shown to be a more powerful ortho/para directing group than the acetamido, methoxyl and methyl groups in aromatic nitrations.
A new approach for the synthesis of 4-chloro-2-fluoronitrobenzene
Authors: Xu Zhen-Yuan , Du Xiao-Hua , Xu Xiang-Sheng , Ni Yue-Biao
Published: December 2009

A new approach to the preparation of 4-chloro-2-fluoronitrobenzene in high purity is developed using 3-chloroaniline as a starting material, comprising acetylation, nitration, deprotection and a Schiemann reaction.
Synthesis of indolo-quinonediimine derivatives by the thermolysis of 5-(1-benzotriazolyl)-substituted spiro[2H-benzimidazole-2,1′-cyclohexane]
Authors: Le Huu Phuoc , Kelbig Anna , Lindauer Andreas , Neidlein Richard , Suschitzky Hans
Published: December 2009

Nucleophilic introduction of the 1H-benzotriazole ring into spiro[2H-benzimidazole-2,1′-cyclohexane] and spiro[2H-imidazo[4,5-b]pyridine-2,1′-cyclohexane], followed by Graebe-Ullmann thermolysis, and also the reduction and formic acid cyclization of five spiro[cyclohexane-1,2′-2′H-imidazo[4,5-b]pyridine] derivatives to give 5-substituted 1H-imidazo[4′,5′:5,6]pyrido[1,2-a]benzimidazoles, are described.
Effect of buffers on partition equilibrium of phenol red in benzene/water/SDS-butanol oil/water microemulsions
Authors: Sarma Surashree , Dutta Robin K.
Published: December 2009

The effect of buffer on the partition of phenol red, an anionic dye, between the oil–water (o/w) interface, oil droplet core and the buffered bulk water in benzene/water/SDS-butanol o/w microemulsions have been studied with phosphate and Tris buffer systems.
Fries-type rearrangement of acylanilides in the presence of ytterbium triflate
Authors: Su Weike , Jin Can
Published: December 2009

Ytterbium triflate has been used to catalyse the Fries-type rearrangement of various acylanilides with moderate yields when lithium perchlorate was used as co-catalyst.
Solid-phase synthesis of acrylamides with polymer-bound 2-sulfonylpropanoic acid
Authors: Sheng Shou-Ri , Zhou Wei , Sang Xiao-Yan , Liu Xiao-Ling , Wang Qiu-Ying
Published: December 2009

A novel polystyrene-bound 2-sulfonylpropanoic acid has been developed and applied to convenient, traceless synthesis of acrylamides in good yield and purity.
One-pot reductive conversion of nitroarenes to N-arylacetamides mediated by metallic samarium
Authors: Zhang Yandong , Zhang Yongmin
Published: December 2009

Nitroarenes can be reduced and then converted to N-arylacetamides by metallic samarium in the presence of acetic anhydride, acetic acid and methanol in excellent yields by a one pot-procedure.
DFT Calculations on Retro-Ene Reactions Part I: Allyl n-Butyl Sulfide Pyrolysis in the Gas Phase
Authors: Izadyar M. , Jahangir A. H. , Gholami M. R.
Published: December 2009

The mechanism and kinetic aspects of the retro-ene reaction of allyl n-butyl sulfide and its deuterated derivative were studied using four different types of density functional theory (DFT) methods with eight different levels of the basis sets. Vibrational frequency analysis confirmed that the stationary points include the transition state (TS) structure with only one imaginary frequency. Mechanistic studies on the retro-ene process rejected the step-wise mechanism and confirmed that the reaction proceeds through a six-centered cyclic transition state. Theoretical calculations show that propene elimination from the reactant can occur through an asynchronous concerted mechanism. A primary kinetic isotope effect of 2.21 for the reaction can be determined. Theoretical kinetics and activation energies especially at the B3LYP/6-31G* levels are in good agreement with the experimental values.
Ligand-free Suzuki–Miyaura reaction catalysed by Pd/C at room temperature
Authors: Zhang Guolin
Published: December 2009

Ligand-free Suzuki–Miyaura coupling reaction has been developed which utilises a commercially available 10% Pd/C (2.6 mol% Pd) in 2-propanol-H2O (1/1) and Na3PO4 at room temperature. The reaction is mild and generates excellent yields of the coupled products (90–100%). The catalyst is heterogeneous and ligand-free, and the product isolation is simple.
Dicopper(II/II) complexes of an amine phenol hexadentate ligand showing μ-bis(tridentate) coordination: EPR spectral model of binuclear CuA centre of nitrous oxide reductase
Authors: Bera Manindranath , Mahato Sanjit Kumar , Ray Debashis
Published: December 2009

A new family of binuclear Cu(II)–Cu(II) complexes with a hexadentate Schiff base ligand containing imine-phenol end groups has been studied as an EPR spectral model of the binuclear CuA centre of nitrous oxide reductase. The complexes have been characterised by elemental analysis, solution electrical conductivities, IR, UV-vis, EPR spectral, magnetic studies and geometrical optimisation by molecular mechanics (MM2) method.
Magnetic susceptibility and aromaticity in the excited states of benzene
Authors: Kataoka Masahiro
Published: December 2009

A numerical method for obtaining the change in energy due to a magnetic field of given strength is applied to calculations of π-electronic delocalisation susceptibilities of the low-lying excited states of benzene. It is found that the delocalisation susceptibilities of the excited states of benzene are quite different from those of the ground state. On the basis of the calculated results, the aromaticity of the excited states of benzene is discussed.
An unusual intramolecular hydrogen transfer during the hydrolysis of a chloroacetoxy ester
Authors: Hanson James R. , Mobbs Daniel J.
Published: December 2009

An intramolecular hydrogen transfer from the chloroacetoxy group has been shown to occur in the hydrolysis of the sesquiterpenoid derivative, 5β-chloroacetoxy-15-norpanasinsan-8-one leading to the formation of 5ββ,8α-dihydroxy-15-norpanasinsane.
Enaminones as building blocks in heterocyclic synthesis. Synthesis of polyfunctionally substituted 3-azolylpyridines and azolylazoloazines by thermal and microwave heating
Authors: Al-Saleh Balkis , Behbehani Haider , El-Apasery Morsy Ahmed , Einagdi Mohamed Hilmy
Published: December 2009

2-Azolyl-3-enaminones (la–e) react with ethyl cyanoacetate to yield 2-pyridones or 2-aminopyridines depending on the reaction conditions. The reaction of la with benzoylacetonitrile afforded a pyridine derivative. Condensation of heteroaromatic aminoazoles with la–e afforded azolopyrimidines. HMBC and NOE difference experiments assisted the assignment of structures to the reaction products.
A Prospective Multidonor Ligand: 2,6-Bis(Thiomorpholino)-p-Cresol: Synthesis, Spectroscopic and Crystal Structure Analysis
Authors: Girija C.R. , Begum Noor Shahina , Naik A.D. , Revankar V.K.
Published: December 2009

An X-ray structure investigation of 2,6-bis (thiomorpholino)- p-cresol has been performed. The two thiomorpholino-groups have adopted the chair conformation and the cresol ring has deviated from planarity. The Willgerodt–Kindler reaction has been used to prepare this prospective ligand, having O, N and S donor sites, in a one pot synthesis.
Wittig Reaction on 5,8-Dimethyl-2-Tetralone. A Total Formal Synthesis of Emmotin-G Methyl Ether
Authors: Banerjee Ajoy K. , Vera William J.
Published: December 2009

The conversion of tetralone 2 to 6-methoxy-7-acetyl-1,4-dimethylnaphthalene 7, a precursor for Emmotin-G methyl ether is described.
Reductive Cleavage of the Se–Se Bond in the Presence of a Zn/AlCl3 System: Synthesis of Selenol Esters
Authors: Movassagh Barahman , Shamsipoor Mojgan , Joshaghani Mohammad
Published: December 2009

Selenol esters were prepared in good yields by reacting diselenides with carboxylic acid anhydrides in dry acetonitrile in the presence of a Zn/AlCl3 system.
Cyclodextrin-Modified Gold Nanoparticle Aggregate formed by Simple host–Guest Interactions with 1,10-Phenanthroline
Authors: Liu Yu , Song Shi-Hui , Yang Ying-Wei , Chen Yong
Published: December 2009

An aggregate of gold nanoparticles modified with thiolated β-cyclodextrin was fabricated through the linkage of PHEN and characterised by FT-IR, UV-vis, fluorescence and STM techniques, showing that the aggregate formation was a concentration-dependant behaviour.
Directing Effects in the Hydroboration of Steroidal Alkenes
Authors: Hanson James R.
Published: December 2009

The balance between steric and electronic effects on the regiochemistry of the hydroboration: oxidation of steroidal alkenes is reviewed.
A Facile Stereoselective Synthesis of Functionalised Cyclobutenes and Electron-Deficient 1,3-Dienes
Authors: Asghari Sakineh , Zaty Mehdi , Bijanzadeh Hamid Reza
Published: December 2009

Protonation of the 1:1 intermediate produced in the reaction between dialkyl acetylenedicarboxylates and triphenylphosphine by ethyl 4,4,4-trifluoroacetoacetate leads to vinyltriphenylphosphonium salts: the positively charged ion reacts with the anion of ethyl 4,4,4-trifluoroacetoacetate to form ylides 5a–c, which undergo intramolecular Wittig reaction to produce 1-ethyl 2,3-dialkyl 4-(trifluoromethyl)-3-cyclobutene-1,2,3-tricarboxylate, which undergo electrocyclic ring-opening reactions in boiling toluene to produce highly electron-deficient 1, 3-dienes in fairly good yields.
A Facile Synthesis of 2,5-Dihydroisoxazoles via an Organoselenium-Induced Stereoselective Cyclisation and Deselenylation Reaction
Authors: Huang Xian , Tang E
Published: December 2009

The organoselenium-induced ring-closure reactions of O-allyl oximes give cyclic iminium salts that can be reduced in situ with NaBH4 to produce N-alkyl-4–phenylselenoisoxazolidines; selenoxide syn-elimination follows to form 2, 5-dihydroisoxazoles in good yields.
Organic Reactions in Aqueous Media: InF3 Catalysed Synthesis of Bis(Indolyl)Methanes in Water Under Mild Conditions
Authors: Bandgar B.P. , Shaikh K.A.
Published: December 2009

InF3 catalysed electrophilic substitution reactions of indoles with aldehydes and ketones are carried out in water to furnish the corresponding bis(indolyl)methanes in high yield under mild conditions.
A Facile Synthetic Route to two Chalcones
Authors: Du Zhenting , She Xuegong , Ma Junying , Wang Zikun , Wu Huafang , Li Yang , Pan Xinfu
Published: December 2009

A facile total synthetic route to two naturally occurring chalcones with a partially methylated structure has been achieved in good yield. The key step was selective deprotection of a MOM ether in the aryl methyl ether 6 by a solid phase reaction.
Efficient Synthesis of the Styryllactones, (+)-Goniothalamin, (+)-7-epi-Goniodiol and (+)-9-Deoxygoniopypyrone
Authors: Liu Zhi-Yu , Ji Jian-Xin , Li Bo-Gang
Published: December 2009

An efficient synthesis of (+)-goniothalamin is described with aldehyde 4 as the key intermediate; the absolute configuration of (+)-7- epi-goniodiol was determined through its asymmetric synthesis from (+)-goniothalamin and, based on the conformation analysis of the four dihydroxylated isomers of (+)-goniothalamin, it can be concluded that the absolute configuration of the hydroxy at C8 determines the forms in nature.
Microwave-Accelerated Solventless Sonogashira-Like Coupling Reaction of 1,1-Dibromo-1-Alkenes with Organic Halides on Nickel(0) Powder-Doped KF/Al2O3
Authors: Yan Jincan , Wang Zhiyuan , Wang Lei
Published: December 2009

Under solvent free and microwave irradiation reaction conditions, a Sonogashira-like coupling reaction of 1,1-dibromo-1-alkenes with organic halides on nickel(0) powder-doped KF/Al2O3 has been developed, which generates the corresponding alkynes in moderate to good yields.
Synthesis and Resolution of a Tetrahedral Cluster Containing the Serucomo Core
Authors: Zhao Quan-Yi , Hu Bin , Zhang Wei-Qiang , Yin Yuan-Qi , Xia Chun-Gu
Published: December 2009

A new cluster derivative ( μ3-Se)RuCoMo(CO)8CpCOOCH33 was obtained by the reaction of SeRuCo2(CO)91 with the functionally-substituted sodium cyclopendiene [Mo(CO)8CpCOOCH3]Na 2 in THF at 60°C and its structure has been determined by single-crystal X-ray diffraction.
A Simple Strategy for the Synthesis of 3,4-Disubstituted Pyrroles
Authors: Padmavathi V. , Reddy B. Jagan Mohan , Sarma M. Rajagopala , Thriveni P.
Published: December 2009

3,4-Disubstituted pyrroles are prepared by cyclocondensation of aryl styryl sulfones and benzyl styryl sulfones with tosyl methyl isocyanide. Phenyl vinyl sulfone under similar conditions forms 3-benzenesulfonylpyrrole and/or 2-(2-benzenesulfonylethyl)-4-benzenesulfonylpyrrole.
Tribenzoyldihydropyridinols from Dibenzoylacetylene and Imines
Authors: Gomaa Mohsen Abdel-Motaal
Published: December 2009

The reaction of dibenzoylacetylene with N,N′-dialkyl or N,N′-diaryl glyoxal-bisimnes or with benzylideneanilines in boiling ethanol leads to the formation of pentasubstituted 1,2-dihydropyridines in 52–87 % yield together with the corresponding enamines derived from dibenzoylacetylene.
Benzopyrans. Part 451. Reactions of Monobrominated 3-Acetyl-2-Methyl-1-Benzopyran-4-One with Some Binucleophiles
Authors: Ghosh Chandra Kanta , Ghosh Chandreyi , Karak Sumit Kumar , Chakravarty Ajit Kumar
Published: December 2009

The chromone 5, obtained by bromination of 3-acetyl-2-methylchromone (3), gives [1]benzoxepino[4,3- d]isoxazole (10) and [1]benzoxepino[3,4- c]pyrazole (11), respectively, with hydroxylamine and phenylhydrazine, pyrrolo [3,4- b][1]benzopyran (18) with thiourea, thiazole 19 with thioacetamide, and quinoxaline 21 with o-phenylenediamine.
Facile Synthesis of 2H-1,2,4-Benzothiadiazine 1,1-Dioxides Promoted by SmI2
Authors: Su Weike , Cai Hongfei , Yang Bibo
Published: December 2009

2 H-1,2,4-Benzothiadiazine 1,1-dioxides are prepared in good yields via reductive cyclisation of N,N-diethyl- o-nitrobenzenesulfonamides with appropriate nitriles promoted by SmI2 under mild and neutral conditions.
Synthesis of coumarins via a Pechmann condensation using heterogeneous catalysts1
Authors: Das Biswanath , Venkateswarlu Katta , Mahender Gurram , Holla Harish
Published: December 2009

The synthesis of coumarins via a Pechmann condensation involving the reaction between phenols and ethyl acetoacetate has been carried out using two heterogeneous catalysts, NaHSO4.SiO2 and silica chloride under solvent free conditions, thus avoiding acidic waste
The Ar–Cl···HO hydrogen bond of 6-chloro-9-hydroxy-[3.3]metacyclophane
Authors: Takemura Hiroyuki , Kotoku Masayuki , Yasutake Mikio , Shinmyozu Teruo
Published: December 2009

The chlorophenol moiety of the titled cyclophane showed intermolecular hydrogen bonds, O–H···OH and C-Cl···HO, in the crystals.
Synthesis of straight arm chains substituted dibenzo-21-crown-7 derivatives
Authors: Du Ying , Li Jianzhang , Wei Xingyao , Zhou Bo , Qin Shengying
Published: December 2009

A series of straight arm chains substituted dibenzo-21-crown-7 derivatives 2a–c, 3a–c, and 5a–c have been synthesised by the Huang Minlon method or reduction with sodium borohydride from the corresponding dibenzo-21-crown-7 bridged diketones 1a–c and 4a–c, which were obtained by diacylation of dibenzo-21-crown-7 with excessive mono- or dicarboxylic acids in the presence of polyphosphoric acid. All new compounds were characterised by IR, MS, 1H NMR and elemental analysis.
New phenol derivatives from Ligularia stenocephala
Authors: Yan Fu-lin , Wang Ai-xia , Jia Zhong-jian
Published: December 2009

The C–3 2-methyl-but-2-enoic acid ester of 2-(1-1-acetoxyisopropenyl)-5-acetyl-3,6-dihydroxy-2,3-dihydro-benzofuran (1) and 6-acetyl-7-hydroxy-2-isopropylidene-benzo[1,4]dioxin-3-one (2), together with nine known compounds (3–11) were isolated from the roots of Ligularia stenocephala. Their structures were elucidated by spectroscopic methods (IR, MS, 1H, 13C and 2D NMR).
The first synthesis of (–)-4-(1,5-dimethylhex-4-enyl)-2-methylphenol
Authors: Shan Shaojun , Ha Chengyong
Published: December 2009

The first synthesis of (–)-4-(1,5-dimethylhex-4-enyl)-2-methylphenol from (+)-citronellal is described.
Synthesis and crystal structure of the chiral-linked tetrahedral cluster [(μ3-Se)RuCo2(CO)8]2 (DIOP)
Authors: Zhu Bao-Hua , Hong Hong , Yin Yuan-Qi , Sun Jie
Published: December 2009

The new chiral Ru–Co mixed-metal linked tetrahedral cluster [(μ3-Se)RuCo2(CO)8]2(DIOP) 3 has been synthesised from reaction between (μ3-Se)RuCo2(CO)9 1 and the (–)-DIOP [2 (2,2-dimethyl-1,3-dioxolane-4,5-diylbis-methylene) bisdiphenylphosphine] diphosphine compound. The structure of cluster 3 has been established by single-crystal X-ray diffraction method.
Synthesis and spectroscopic characterisation lithocholic acid derivatives
Authors: Nahar Lutfun , Turner Alan B.
Published: December 2009

The synthesis of five lithocholic acid derivatives, 5β-cholane-3α,24-diol (2), 3α-hydroxy-5β-cholan-24-yl tosylate (3), 5β-cholan-3α,24-yl ditosylate (4), 3α-tosyloxy-5β-cholan-24-yl chloride (5) and 3-oxo-5β-cholan-24-al (6) have been described.