bluuebunny/crossref_metadata_2025 huggingface dataset:
STUDY ON TRANSCRIPTION POSSIBILITY OF EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) GENE IN BREAST CARCINOMA TISSUES BY REVERSE TRANSCRIPTION-PCR ASSAY
Authors: Ho Hoang Thi Kim Hue , Ha Thi Minh Thi , Phan Thi Minh Phuong
Published: March 2020

Background: EGFR is a member of the EGFR family- type I transmembrane tyrosine kinase receptors, which plays an essential role in development and growth of body. However, EGFRs are frequently overexpressed, this overexpression and its signal pathway induce unrestricted development and uncontrolled proliferation in human malignant tumors including breast carcinoma, one of the most common cancer in women. Objective: (1)To evaluate transcript level of EGFR gene in breast carcinoma tissues by RT-PCR assay.(2)To compare transcript level of EGFR gene in breast carcinoma with breast fibro adenoma. Subject and Methods: total RNA from 70 samples including 38 breast carcinoma tissues and 32 breast fibroadenoma tissues were extracted. EGFR transcript level were determined using semi-quantitative Reverse Transcription-PCR assay. PCR products were tested by electrophoresis on agarose gel 2%. Results: RNA total concentration in breast carcinoma tissues was 170.03 ± 201.17 ng/µl, was significantly higher in breast fibro adenoma tissue: 65.96 ± 43.16 ng/µl (p<0.05). EGFR transcript level was highly expressed in breast carcinoma compared to breast fibro adenoma (1.22 ± 0.24 compared to 0.75 ± 0,19) (p< 0.0001). The cut-off point of the rate EGFR/GAPDH was 0.97, area under the curve: 0.913, p< 0.0001, sensitivity and specificity were 81,58% and 93.75%. Conclusion: Transcript level of EGFR gene in breast carcinoma was significantly 1.63 times higher than in breast fibro-adenoma. The cut-off point of the rate EGFR/GAPDH was 0.97, sensitivity: 81.58% and specificity: 93.75%.

Key words: EGFR, RT-PCR, breast carcinoma
THE RELATIONSHIP BETWEEN SERUM LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 LEVELS AND CLINICAL STROKE SEVERITY, INFARCT VOLUME IN PATIENTS WITH ACUTE ISCHEMIC STROKE
Authors: Le Van Tam , Nguyen Dinh Toan , Vo Trong Hao , Doan Vu Xuan Loc
Published: March 2020

Background and Purpose: The studies showed that elevated inflammation indicators were an associated with risk for ischemic stroke and useful in prediction of ischemic tissue volume. We studied the association between serum lipoprotein-associated phospholipase A2 (Lp-PLA2) levels and clinical stroke severity, infarct volume in acute ischemic stroke. Methods: The cross – sectional study, in 119 patients who presented to Department of Cardiology and Intensive Care Unit – Hue Central Hospital; 115 controls. Stroke patients were evaluated with Glagow Coma Scale and National Institutes of Health Stroke Scale (NIHSS) and their serum Lp-PLA2 and hs-CRP level, plasma lipid profile, blood glucose were assessed. Results: The mean age of patients was 66.03 years, in controls was 63.49 years (p > 0.05). Patients who had stroke had higher median serum Lp-PLA2 level than controls (22.03 IU/ml vs 10.23 IU/ml; p < 0,05). The median Lp-PLA2 level were higher in patients who had greater stroke severity (lower Glagow Coma Scale score, higher NIHSS score) and were higher in patients who had larger volume strokes. There were strong correlation between Lp-PLA2 levels and Glasgow Coma Scale (r = -0.53; p < 0.05); Lp-PLA2 levels and NIHSS (r =0.51; p < 0.05); Lp-PLA2 levels and infarct tissue volume (r = 0.58; p < 0.05). Conclusion: Higher Lp-PLA2 levels was significantly associated with more severe neurological impairment and larger infarct size in patients who had acute ischemic stroke. This biomarker may be useful for rapid diagnosis and prediction of ischemic tissue volume in the early stage of ischemic stroke.

Key words: Stroke, atherosclerosis, inflammation, biomarker
EFFICACY OF ERYLIK ON TREATMENT OF ACNE VULGARIS
Authors: Mai Ba Hoang Anh , Pham Thi Lan
Published: March 2020

Introduction: Acne vulgaris is a common disease that is an inflammation of pilosebaceous unit, frequent in adolescent. Objective: evaluate efficacy of Erylik on treatment of acne vulgaris. Methodology: this is a clinical controlled study comparing pre and post-treatment, including 31 patients treated at National hospital of Dermatology and Venereology from 4/2012-8/2012. Results: after 4 weeks, comedones decreased 17,9%, inflammatory lesions decreased 30,1%, total lesions decreased 22,5%; mild grade 70,9%, moderated grade 29,1. After 8 weeks: comedones decreased 35,2%, inflammatory lesions decreased 52,3%, total lesions decreased 41,4.%; moderate grade 80,6%, good grade 19,4%. Side-effect of Erylik: erythema, dryness, desquamation, burning. Conclusion: Erylik is good for treatment Acne vulgaris, has a good result with clearly ameliorated lesions.
APPLYING MIDDLE CELEBRAL ARTERY DOPPLER ON PREDICTING OF FETAL DISTRESS ASSOCIATED WITH PREECLAMPSIA
Authors: Phan Thi Duyen Hai , Nguyen Tran Thao Nguyen , Le Lam Huong
Published: March 2020

Objectives: To study the value of the Doppler resistance index of middle celebral artery and its correlation to predict fetal distress associated with pre-eclampsia. Methods: 102 patients with pre-eclampsia at Obs. & Gyn. Department – Hue Central Hospital were taken by a prospective cohort study. Results: Mean of RI middle cerebral artery was 0.70 ± 0.08 (0.49-0.92, 95% CI). The rate doppler resistance index of middle cerebral/umblical artery < 1 was 27/102 (26.4%). There was no correlation between resitance index of middle cerebral artery and fetal distress status. The rate doppler resistance index of middle cerebral/umblical artery had a close relation to abnormal fetal after delivery. Conclusion: The doppler resistance index of middle cerebral artery was not a predict factor of fetal distress associated with pre-eclampsia.

Key words: Doppler, middle celebral artery, fetal distress, pre-eclampsia
ECHOCARDIOGRAPHY PREDICTORS OF SUCCESSFUL MITRAL VALVE REPAIR IN DEGENERATIVE MITRAL VALVE REGURGITATION
Authors: Le Ba Minh Du , Nguyen Anh Vu , Bui Duc Phu
Published: March 2020

Background and aim of the study: Mitral repair is now as the treatement of choice in patients suffering mitral regurgitation due to mitral valve prolapse or flail. However, mitral valve repair demands the mitral valve morphology being feasible for repair. The study aims at evaluating transthoracic and transesophageal echocardiographic features in consecutive patients with mitral valve prolapse or flail undergoing surgical repair at Hue Central Hospital. The correlation between preoperative and intraoperative echocardiographic features and surgical findings in these patients. These echocardiographic data may predict the surgical outcome. Methods: From December 2010 to January 2013, 73 patients (37 men, 36 women; average age 37.5) were recruited into the study. All patients had degenerative mitral valve disease causing important regurgitation and underwent systematic preoperative transthoracic echocardiography, preoperative and intraoperative transesophageal echocardiography for delineation of six segments (scallops) of anterior and posterior leaflets. Results: Among 73 patients, 64 patients were in fibroelastic deficiency (87.7%) and 9 patients suffered Barlow disease (12.3%). Mitral valve repair was performed in 52 patients (71.2%) and mitral replacement was performed in 21 patients (28.8%). All 52 mitral valve repair (81.3%) and 12 mitral valve replacement (18.7%) was performed in fibroelastic deficiency patients. All 9 Barlow patients must undergo mitral valve replacement (100%). A prolapse or flail of mitral valve in 73 patients was documented by transthoracic and transesophageal echocardiography and confirmed on surgical inspection. Accuracy of transthoracic echocardiography was (89.0%) and accuracy of transesophageal echocardiography was (91.8%) in identifying mitral valve segments prolapse or flail. Success rate of mitral valve repair was (98.0%) in prolapse of 1 or 2 segments, but was low (36.0%) in prolapse > 3 segments. Success rate of mitral valve repair was (96.6%) in prolapse of posterior leaflet, but was (63.6%) in prolapse anterior leaflet or bileaflet. Conclusion: - Mitral valve repair was favorable in fibroelastic deficiency patients, but difficult in Barlow patients. - Accuracy of transthoracic and transesophageal echocardiography was high in identifying mitral valve segments prolapse or flail. - Success rate of mitral valve repair was high in prolapse of 1 or 2 segments. - Success rate of mitral valve repair was high in in prolapse of posterior leaflet. Key words: Mitral repair, echocardiography, degenerative, Barlow, fibroelastic deficiency, prolapse, flail
SONOGRAPHIC CHARACTERISTIC OF GALLBLADDER POLYPS
Authors: Nguyen Thi Thuy Trang , Le Van Toan , Hoang Minh Loi
Published: March 2020

Objective: To evaluate ultrasound characteristic imaging of gallbladder polyps. And to compare ultrasound imaging with the results of surgery and histopathologyfor positive diagnosis of gallbladder polyps. Subjects and methods: Study on 32 patients (14 male and 18 female, mean age 43,5±18,5 years) with clinical suggestion, ultrasound imaging of gallbladder polyp, and surgery -histopathology positive diagnosis. Cross-sectional descriptive study, from 5/2014 to 3/2015 at the Hospital of Hue Medical and Pharmacy College. Results: Among of 32 patients, 18 patients (56,2%) had results postoperative histopathology of chronic cholecystitis, 14 patients (43,8%) was the type of polyps and adenoma. Thus the specificitive of ultrasound in diagnosis of gallbladder polyps was 43,75% only. Conclusion: The role of ultrasound in diagnosis of gallbladder polyps is the firstscreening for the other indications and ultimate treatment. Key words: ultrasound imaging, histopathology, gallbladder polyps.
ROLES OF SO2 INDEX FOR PREDICTING OF FLUID RESPONSIVENESS IN HIGH RISK CARDIAC SURGICAL PATIENTS
Authors: Doan Duc Hoang , Bui Duc Phu , Huynh Van Minh
Published: March 2020

Purpose: (1) Study the change in SO2 value in fluid therapy in patients after cardiac surgery; (2) Evaluate the role of SO2 monitoring in serving as an indicator of fluid responsiveness in patients after cardiac surgery. Methods: This was a prospective study reported earlier on critically ill patients with clinical hypovolemia after cardiac surgery. Fluid therapy was guided by changes in pulmonary artery wedge pressure or central venous pressure. Fluid responsiveness was defined as ≥15% increase in cardiac index. Hemodynamics, including left ventricular ejection fraction, cardiac index, and oxygen delivery were measured when SO2 blood samples taken. Results: There was 110 patients receiving fluid therapy in postoperative period. The SO2 increased in 104 patients responding to fluid loading (≥15% in cardiac index in n=107) versus those not responding (n=6). The increase in ejection fraction, cardiac index and oxygen delivery was also greater in responders (p=0.005). The area under the receiver operating characteristic curve for fluid responsiveness of changes in SO2 was 0.78 (p=0.05), with an optimal cutoff of 2%. The value of SO2 increased to reflect cardiac index increases with fluid loading was in 66.7% of patients. Conclusions: An increase in SO2 ≥ 2% can thus be used as an indicator of fluid responsiveness in clinically hypovolemic patients after cardiac surgery, particularly in those with systolic cardiac dysfunction. Fluid responsiveness concurs with increased tissue oxygen delivery. Key words: mixed venous oxygen saturation (SO2); oxygen delivery (DO2); oxygen consumption (VO2); central venous pressure (CVP), pulmonary artery wedge pressure (PAWP); cardiac index (CI); hypovolemia; fluid therapy.
LUNGRADS AND UPDATE OF LUNG NODULES SCREENING BY LOW DOSE COMPUTED TOMOGRAPHY
Authors: Hoang Thi Ngoc Ha , Le Trong Khoan
Published: March 2020

Background: A pulmonary nodule is defined as a rounded or irregular opacity, well or poorly defined, measuring up to 3 cm in diameter. Early detection the malignancy of nodules has a significant role in decreasing the mortality, increasing the survival time and consider as early diagnosis lung cancer. The main risk factors are those of current or former smokers, aged 55 to 74 years with a smoking history of at least 1 pack-day. Low dose CT: screening individuals with high risk of lung cancer by low dose CT scans could reduce lung cancer mortality by 20 percent compared to chest X-ray. Radiation dose has to maximum reduced but respect the rule of ALARA (As Low as Resonably Archivable). LungRADS 2014: Classification of American College of Radiology, LungRADS, is a newly application but showed many advantages in comparison with others classification such as increasing positive predict value (PPV), no result of false negative and cost effectiveness. Key words: LungRADS, screening lung nodule, low dose CT, lung cancer
MATERNAL SERUM PAPP-A LEVELS AT 11+0 TO 13+6 WEEKS OF GESTATION IN THE PREDICTION OF HYPERTENSION DISORDER
Authors: Cao Ngoc Thanh , Vo Van Duc , Nguyen Vu Quoc Huy , Truong Quang Vinh , Nguyen Viet Nhan , Ha Thi Minh Thi , Nguyen Tran Thao Nguyen , Truong Manh Linh
Published: March 2020

Objective: To detect maternal serum PAPP-A levels at 11-13 weeks 6 day of gestation in pregnancies who subsequently develop pre-eclampsia and to evaluating the role of these screening PAPP-A in the prediction of pre-eclampsia. Materials and methods: Prospective screening study for preeclampsia in pregnant attending their first hospital visit at 11-13 weeks 6 of gestation. The performance of screening for PE by serum PAPP-A and free βhCG were determined. Results: Of 2,998 patients with complete outcome data, there were 3.74% of hypertension disorder, and 2.84% cases of pre-eclampsia. free βhCG levels were no different significantly in pregnancy who developed pre-eclampsia compared to the control group. PAPP-A levels were significantly lower in pregnants who developed early pre-eclampsia (0.653 MoM) and late pre-eclampsia (0.744 MoM) compared to the control group (1.039 MoM).In screening for PE by combinematernal factors and PAPP-A,at false positive rate of 5%, the estimateddetection rates were 36.4% and the detection rates were 54.6%, at at false positive rate of 10%. Conclusion: Low PAPP-A levels are associated with the development of preeclampsia; however, it should be combined with other tests to increase effectiveness of hypertension disorder screening at the first trimester. Key words: preeclampsia; gestational hypertension; screening; PAPP-A.
FOOD CONSUMPTION OF CHILDREN AGED 1 TO 5 IN PHUOC VINH WARD, HUE CITY BY 24 HOURS FOOD RECORDING
Authors: Hoang Thi Bach Yen , Pham Thi Hai , Hoang Dinh Tuyen , Le Thi Huong , Vo Van Thang
Published: March 2020

Food consumption survey is an essential parts of nutrition surveys. It helps to determine the type and quantity of food consumed, assessing the balance of the diet, the relationship between nutrient intake and health, diseases, and economic status, culture society... There are many methods to investigate food consumption. 24-hour food record is a method that record all food consumed by the subject during previous 24 hours. Using this method in chidren helps to assess the their diet to see if it responses the demand in order to have proper nutrition. Objectives: 1. Calculating the number of each food groups consumed within 24 hours of children 1 to 5 years in Phuoc Vinh ward, Hue City; 2. Assessing the quality of their diet and some related factors. Methodology: A cross-sectional study was implemented on 200 pairs of children aged 1 to 5 and parents or caregivers living in Phuoc Vinh ward, Hue city and some related factors. Results: 82% of the children’s diets covered 4 food groups. Prevalence of glucide, protein, lipide out of the total energy intake were 44.1%, 19.5%, 36.3% respectively within group of 12-<48 months and 50%, 19.5%, 30.6% respectively within group of 48-<72 months. Total energy and protein intake were higher than demanded (p <0.05) while glucide and lipide were lower than demanded (p <0.05). Economical status of family was significant associated with variety of food (all 4 food groups) in the diet of children (p <0.05) and total energy consumed (p <0.05). Conclusion: The children did not have proper nutrition so further research need to be implemented to have suitable interventions. Key words: 24 hours food records, children aged 1 to 5, Hue city.
A CASE STUDY OF THE DIASTEMATOMYELIA IN HUE UNIVERSITY HOSPITAL
Authors: Le Van Ngoc Cuong
Published: March 2020

Diastematomyelia is a rare congenital malformation anomaly that results in the splitting of the spinal cord in a longitudinal direction. It is caused by the presence of the septum of bone, the cartilage or the fibers in spinal canal. This septum vertical distribution of cord or spinal canal that is divided into two hemicords can be complete or incomplete. In the case of complete separation that isn't consolidated until the terminal filum and that is called the duplicated spinal cord. Key words: Diastematomyelia, splitting, congenital malformation, duplicated spinal cord.
DETERMINATION OF MUTATIONS IN 23S RRNA GENE OF HELICOBACTER PYLORI AND THE ASSOCIATION OF THESE GENE MUTATIONS WITH CLARITHROMYCIN-RESISTANCE IN CHRONIC GASTRITIS
Authors: Ha Thi Minh Thi , Tran Van Huy , Nguyen Viet Nhan , Le Phan Tuong Quynh , Phan Trung Nam , Tran Thi Nhu Hoa
Published: March 2020

Background: Resistance of Helicobacter pylori to clarithromycin is mostly due to the point mutations in the 23S rRNA. The aims of the present study were to determine mutations in domain V of 23S rRNA gene of Helicobacter pylori in chronic gastritis patients by sequencing; and to assess the association of these mutations with clarithromycin-resistant phenotype determined by E-test. Patients and methods: Gastric mucosal biopsy specimens from 170 patients with chronic gastritis were entered in the study. DNA was extracted from biopsy specimens obtained by endoscopy and prepared for sequencing domain V of gene 23S rRNA. 80 biopsy specimens were determined MIC by E-test. Results: Eight point mutations were detected. At 2142 and 2143 sites of gene, A2143G and A2142G mutations were detected in 35.3% and 3.5%, respectively. Six remaining mutations were G2172T (0.6%), T2182C (86.5%), C2195T (5.3%), A2223G (42.9%), T2244C (98.2%) và A2302G (8.8%). A2143G mutation was associated with clarithromycin-resistant phenotype, OR = 368.58 (95%CI: 34.53 – 3934.12). The rate of clarithromycin-resistance in the group with A2143G mutation was 96.7%, while in the group without A2143G mutation was 10%. Predicted probabilities for clarithromycin-resistance were calculated by logistic regression model with the accuracy rate of 96.1%. Conclusions: There was the association between A2143G mutation and clarithromycin-resistant phenotype. Genotypes determined by sequencing domain V of 23S rRNA gene could be used to predict the probabilities of clarithromycin-resistance. Key words: 23S rRNA gene, clarithromycin-resistance, Helicobacter pylori
LAPAROSCOPIC TOTAL EXTRAPERITONEAL REPAIR OF INGUINAL HERNIA DIRECT: NONFIXATION OF THREE-DIMENSIONAL MESH
Authors: Phan Dinh Tuan Dung , Pham Anh Vu , Le Manh Ha
Published: March 2020

Introduction: Laparoscopic inguinal hernia repair frequently is performed with mechanical fixation of a flat polypropylene mesh. Mechanical fixation is associated with pain syndromes and mesh migration may occur without fixation of flat protheses. An anatomically contoured mesh 3D-Max (3DMAX Mesh/Bard-Davol, France) using no fixation would avoid these problems. The objective of this study is to demonstrate the effectiveness and safeness of laparoscopic totally extraperitoneal (TEP) hernia repair with nonfixation of three-dimensional mesh. Materials and methods: A prospective analysis of patients, admitted for groin hernia type direct and operated by laparoscopic TEP hernia repair with nonfixation of 3D mesh (3DMAX Mesh), performed between June 2010 and June 2015. Data were collected regarding general characteristics, complication rates, length of hospital stay and the recurrence rate postoperative of this method. Results: 36 patients/42 hernias type direct underwent laparoscopic totally extraperitoneal (TEP) repair with nonfixation of 3D mesh. The results show with an average age of 59,5±13,2 years (range 36–85 years); peritoneal laceration was noticed during dissection in 7,1%, there was no injury of the inferior epigastric vessels during dissection. Unilateral hernia had an operative time of 54,5±18,1 minutes (range 30–115 minutes), bilateral hernia was 88,3±24,6 (range 65-120 minutes). All of these patients in the study were controlled with 2,4% had pain post-op at 3 months follow-up postoperative, but at 12 months and 24 months follow-up, there were no complication, no recurrences. Conclusions: The laparoscopic (TEP) repair of inguinal hernia with nonfixation of three-dimensional mesh is safe and effective. Keywords: groin hernia – TEP hernioplasty - laparoscopy
EVALUATION THE RATE OF DELAYED PARASITE CLEARANCE IN UNCOMPLICATED PLASMODIUM FALCIPARUM PATIENT AFTER 3 DAYS TREATMENT WITH DIHYDROARTEMISININ PLUS PIPERAQUIN PHOSPHATE (DHA-PPQ) IN HUONG HOA DISTRICT, QUANG TRI PROVINCE
Authors: Phan Thi Hang Giang , Huynh Dinh Chien
Published: March 2020

Background: Malaria is still remains a public health disease with high circulating levels, each year causes the death of about 1.5 million people worldwide, and almost all deaths are caused by falciparum malaria. The emergence of multidrug-resistant P. falciparum parasites has made these drugs useless in many areas where malaria is endemic. As with earlier antimalarial drugs,parasite resistance to artemisinin and its derivatives has emerged in Southeast Asia. Evaluate the effectiveness of antimalarial drug is an essential activity for assessing sensitivity of drug resistance are taking a positive contribution to the prevention of malaria. Research objective: To evaluate the rate of delayed parasite clearance (DPC) in uncomplicated Plasmodium falciparum patient after 3 days treatment with DHA-PPQ in Huong Hoa district, Quang Tri province. Research methods: Cross-sectional studyandempirical research. The research samples included all patients with falciparum malaria uncomplicated in Huong Hoa district, Quang Tri province agreed to participate in our study. There are 84 patients were collected smears and whole blood samples before and after 3 days of treatment with DHA-PPQ for evaluating parasitemiae by microscopy method and Real time PCR. Results: In total 84 samples of malaria patients were collected to determine the rate of delayed parasite clearance (DPC) after 3 days of treatment with DHA-PPQ, there were 22 samples (26.2%) are parasites in blood after treatment 3days determined by microscopy; Real time PCR with 33 samples (39.3%) were parasites in the blood after treatment 3 days. Conclusion: The epidemiology of malaria in our study had a rate of delayed parasite clearance (DPC)after treatment with DHA-PPQ 3 days were 26.2% (22/84 samples) determined by microscopy and 39.3% (33/84 samples) by Real time PCR. As defined by WHO, the study results contribute to the initial report suspected artemisinin resistance occurs in endemic areas of our research. Key words: Plasmodium falciparum, Artemisinin.
STUDY THE CLINICAL CHARACTERISTICS , COMPUTERIZED TOMOGRAPHY IMAGES AND SURGICAL OUTCOMES OF PATIENTS WITH CONCHA BULLOSA
Authors: Nguyen Nguyen , Phan Van Dung , Le Thanh Thai
Published: March 2020

Background: This study aims to describe clinical characteristics, computerized tomography image of concha bullosa and evaluate the results of surgical patients with concha bullosa. Patients and method: 37 patients with 51 concha bullosa surgeried to partially outside, by the method described cross, from October 2012 to June 2014. Result: Main symptoms of patients with CB is headache (89.2 %) and nasal congestion (67.6 %). In patients with CB often changes the anatomy and pathology with particularly crooked nasal septum (75.7 %). Patients with bilateral CB accounted for 62.2 % of patients had unbiliteral CB is 37.8 %. Location CB: 88.2 % the previous section, the following 2 %, both before and after 9.8 %. Ventilation position of CB: 68.7 % lamellar type, type bulbous 7.8%, and type extensive 23.5 %. The size of CB as assigned Thomas: highest grade 3 (31.1 %) followed by grade 2 (27 %) and grade 4 (6.7 %) was the last grade 1 (4.1%). The size of CB according classified Nadas: highest level 1 (59.5 %), followed by the 0 (31.1 %) and grade 3 (8.1%), and finally grade 4 (1.3 %). Complications of surgery: tear the lining of the septum (18.9 %), multiple intraoperative bleeding (representing 8.1%), mucosal abrasions middle turbinate (accounting for 2.7 %). The incidence of post-operative Art: meche withdrawal bleeding after surgery (13.5 %), bleeding early before 6 hours (5.4 %); Roll stick after surgery (representing 2.7 %), postoperative bleeding before 24 hours. Functional impairment in patients after surgery: After 3 months of headaches decreased 84.8 %, stuffy nose fell 92 %, 90.9 % of reduction talks flow, Itchy nose, sneezing decreased 42.9 %. Middle turbinate endoscopic nasal after surgery: 100 % middle turbinate slim nose. Conclusion: The combined clinical and endoscopic sinus CT will improve the efficiency of diagnosis and treatment concha bullosa. Key words: concha bullosa, deviated nasal septum, rhinosinusal computerized tomographic scanner.
RESULTS OF ENVIRONMENTAL MONITORING IN 6 PROVINCIAL HOSPITALS HIGHLAND AREA 2011-2013
Authors: Tran Duy Tao , Hoang Trong Si
Published: March 2020

Objective: Monitoring and evaluation of air environmental quality, waste water and medical waste management activities in some hospitals in the Central Highlands. Research Methodology: Cross-sectional descriptive survey was deployed in 6 provincial hospitals of the Central Highlands in 7th- 8th months every year for 3 years, 2011, 2012, 2013. Observing the process of waste management in hospitals, weighing the medical solid waste generated daily, sampling and environmental monitoring of air, water waste samples after treatment of hospitals. Findings: The percentage of substandard sample of radioactive 2011 was 5.88%, in 2012 was 5%, 2013 was 0.02%. Mainly in dose laboratories, rinse the nuclear medicine department, hatch covers radioactive waste storage. 100% of the air sample of wastewater treatment areas have NO2 target and 60% of SO2 target sample have not reached allowed regulations. The atmosphere at the garbage area hospitals in Kon Tum and Lam Dong provinces through 2 years of monitoring in 2012, 2013 exceeded SO2 target standards. Monitoring results incinerator emissions sample at 3 hospitals: Kontum, Gia Lai, Dak Nong in 3 years reached Regulations allow. The observation sample treated waste water of the hospital in 2013 with low contamination rate than in 2011 and 2012 in terms of physics and chemistry. Particularly criteria Total coliforms 3 years are from 40-50% of samples exceeded standards. Regarding waste management, the results of monitoring in 2013 showed that 60% of faculties have sharps instruments and 20% of the faculties have satisfactory utensils anatomical waste. 59.48% of the faculties have the guidelines for waste separation. Condition misclassified not many and occur in two hospitals Gia Lai, Dak Lak. Only Lam Dong hospitals have waste transportation vehicles secured closed during transport. The amount of waste / beds / 24 hours is 1.097kg. In particular infectious waste is 0.26kg. Only two hospitals in Daklak, Lam Dong has generated radioactive waste with a total of 0.9 kg/day. Key words: Medical waste, medical waste management.
THE RATE OF CLINICAL AND BIOLOGICAL MANIFESTATIONS IN SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS DIAGNOSED ACCORDING TO THE CRITERIA OF THE SLICC 2012
Authors: Vo Tam , Hoang Thi Phuong Thao , Nguyen Thi Loc
Published: March 2020

Aims: Determine the rate of clinical and biological manifestations in Systemic Lupus Erythematosus patients diagnosed according to the criteria of The Systemic Lupus International Collaborating Clinics SLICC 2012.
Patients And Method: 55 patients were diagnosed with Systemic Lupus Erythematosus according to the criteria of the SLICC 2012, treated and followed up at Department of Nephrology and Rheumatology – Hue Central Hospital from March 2014 to April 2015.
Results: The clinical manifestations rate: acute cutaneous lupus 58,2%; subacute cutaneous lupus 10,9%; chronic cutaneous lupus 10,9%; oral or nasal ulcers 18,2%; nonscarring alopecia 60%; synovitis 54,5%; serositis 32,7%, neurological damage 14,6%. The biological manifestations rate: hemolytic anemia 5,5%; leukopenia <4.000/mm3 25,5%; lymphopenia <1.000/mm3 49,1%; thrombocytopenia <100.000/mm3 16,4%; 24-hour urine protein representing >500 mg protein/24 hours 69,1%; ANA positivity 96,4%; anti-dsDNA antibody positivity 89,1%.
Conclusion: In this study cohort, the clinical manifestations according to the criteria of the SLICC 2012 that have the highest rate are nonscarring alopecia, followed by acute cutaneous lupus and synovitis. The other clinical manifestations with lower rate are oral or nasal ulcers, neurological damage and chronic cutaneous lupus. Regarding biological manifestations, the presence of antinuclear antibodies, anti-dsDNA antibodies and renal damage with proteinuria >500mg/24 hours are the most prominent symptoms.

Key words: Systemic Lupus Erythematosus, SLICC 2012
EVALUATION OF THE DENTIN DESENSITIZING EFFICACY OF PASTE CONTAINING 8% ARGININE AND CALCIUM CARBONATE DURING DENTAL SCALING PROCEDURE
Authors: Bui Thi Bao Trinh , Pham Nu Nhu Y
Published: March 2020

Background: Dentin hypersensitivity (DH) is a short, sharp pain of teeth that can affect quality of life and treatment of oral dental diseases. The objective of this study was to evaluate the dentin desensitizing efficacy after single application of paste containing 8% Arginine and Calcium carbonate (A-C) during dental scaling procedure (DSP).
Methods: This single-blind randomized clinical trial was conducted with 64 patients including 328 teeth with DH in which, group A: application of 8% A-C paste immediately before DSP and group B: application of 8% A-C paste immediately after DSP. On each patient, teeth with DH in both sides of jaw were randomized in 2 groups: the treatment was applied by 8% A-C paste, and the control was applied by pumice prophylaxis paste (PPP). DH scores were evaluated5 times: T0 (base-line), T1 (the group A: immediately after application of 8% A-C paste in the treatment and PPP in the control; the group B: similar to the group A but immediately after DSP), T2 (the group A: immediately after DSP; the group B: immediately after application of 8% A-C paste in the treatment and PPP in the control), T3 (1 week later), and T4 (4 weeks later).
Results: In group A: the treatment had a reduced DH score immediately after applying the 8% A-C paste from T1 to T4 (the reduced percentage of DH of T1, T2, T3, and T4 were 43.11%, 43.11%, 44.89%, and 44.45% respectively) in comparison with baseline score. The group B: immediately after DSP, the DH score increased in both groups but the treatment had a reduced DH score immediately after applying the 8% A-C paste from T2 to T4 (42.32%, 44.81% and 43.98% respectively) in comparison with the T1.
Conclusion: A single application of the 8% A-C paste immediately before or after DSP had an effect on reducing the DH immediately and this effect lasted 4 weeks later.

Key words: Dentin hypersensitivity, paste containing 8% Arginine and Calcium carbonate
Prohibition of Certain Actions: Interpretation and Problems of Enforcement
Authors: Petrovskikh Alla , Smakhtin Evgeny
Published: March 2020

The authors analyze provisions of the Article 105.1 of the Criminal Procedural Code of the Russian
Federation concerning new measure of criminal procedure coercion. The authors have tried to determine
the meaning of the prohibition to periodically leave premises and restriction of communication means usage
in the context of international legal regulation, the European Court of Human Rights and the Constitutional
Court of Russian Federation practice. The provisions that are going to be observed refer to non-violation
of basic personal rights and freedoms in the circumstances characterized by criminal coercion application
connected with restriction of personal liberty. The necessity of new restraint measure correlation with
relevant provisions of the international and Russian law is defied. It is offered to reduce risks during the
European Court of Justice trials due to unifid approach to new restraint measure and basic substantive
law principles application.
The conclusion is made that additional technical and legal regulation of the prohibition of certain
actions is needed. Issues concerning the goals and objectives of the prohibition of certain actions are going
to be discussed in relation to basic criminal procedure law functions. The prospects of the newly established
provisions of the criminal procedure law application regarding the accused coercion to behave obediently
by settling the direct prohibitions for the sake of prosecution functions realization are evaluated. The fild
for the discussion regarding issues of criminal procedure law obtaining attributes of substantive law due
to protective and other criminal law functions reinforcement is being formed.
ON THE FUTURE OF LABOR LAW IN THE ERA OF CHANGE
Authors: LUSHNIKOV ANDREУ , LUSHNIKOVA MARINA
Published: March 2020

Introduction: in this article the authors examine the complex issues related to certain contours of the future of labor law in the conditions of change. An analysis of contemporary Western and Russian literature on the stated topic is given.

Methods: comparative legal, historical, system methods, as well as the modeling method and the formal-logical method.

Analysis: particular attention is paid to the numerical growth of atypical labor relations, which are inherent in the postindustrial society. Their main characteristics associated with a deviation from the three classical cha-
racteristics (personal, organizational and property), as well as from the model of the traditional «working» contract, are proposed. It stressed the importance of information, technological and social aspects of the new organization of work, discussed the problem of «living wage» and the prospects of its solution.

Results: the authors proposed three options for further development of labor law, the most likely one was identified. According to the authors, this option is associated with a reduction in the scope of the mandatory legal regulation of labor relations and the total number of specialized regulatory legal acts, with an increase in the role of judicial law. Accordingly, the role of horizontal (individual-contractual and social-partner) regulation of labor relations increases. The article proposes the author’s periodization of the stages of labor organization. As the conclusions the basic characteristics inherent in labor law of the future are offered: 1) strengthening of flexibility in regulation of labor relations, expansion of the sphere of normative differentiation and contractual regulation;
2) the transformation of labor law towards a comprehensive legal education «human rights in the process of wor-
king life», 3) the growing role of international labor law in connection with the process of globalization.
MEANS OF DIFFERENTIATION OF RESPONSIBILITY FOR IMPLEMENTATION OF FINANCIAL CRIMES
Authors: LAPSHIN VALERY
Published: March 2020

Introduction: modern criminal legislation in terms of ensuring the criminal-legal protection of financial relations needs substantial processing. This is due to the unsatisfactory quality of the differentiation of criminal responsibility carried out for committing socially dangerous encroachments on financial relations. This circumstance is an artificial obstacle to the application of the criminal law with a view to preventing economic (financial) crime.

Methods: dialectical, comparative legal, logical, system analysis and forecasting method.

Analysis: the state of the differentiation of the responsibility, defined by the legislator for the commission of financial crimes, can be considered unsatisfactory for a number of reasons. Firstly, the established responsibility for certain financial crimes does not reflect the significant public danger that is inherently inherent in financial crimes. Secondly, criminalization of separate, previously unknown to the Russian criminal law, acts committed in the financial sector, has complicated enforcement activities of law enforcement and judicial authorities since the emergence undue competition with other norms of responsibility for crimes in the sphere of economic activity. Thirdly, the extension provided for by the criminal law of the possibility of release perpetrators financial and other economic crimes, negative impact on the prevention of economic crime.

Results: the study made a number of proposals to waive inclusion in the domestic criminal law of duplicate rules on liability for financial crimes, to reduce the possibility of release from liability for committing financial crimes, as well as the technique of forming the rules of sanctions on the responsibility for committing both financial and economic crimes in general.
MODERN WORLD ORDER CHARACTERISTICS
Authors: PEREVALOV VICTOR , SHERPAEV VLADIMIR
Published: March 2020

Introduction: in the modern world, the models of civilizational development are changing. The authors analyze the transition from a bipolar model of international relations to a unipolar world, the prospects for the emergence of multipolarity, the growth of power centers, the state of the world legal order and its new content, Russia’s position in the world and probable threats, challenges, development of the regulatory framework and the factors determining Russia’s domestic and foreign policy, defense capability of our country and the CSTO countries. In the coming century, the study of the world order is especially important for ensuring national security. The authors draw attention to the key area of interaction between the EU and NATO, highlighting military mobility (the ability to quickly move forces across Europe, if necessary). It is a matter of concern that over the past four years, NATO has invested 2 billion euros in projects that support military mobility. The signing of the declaration of the EU and NATO on further cooperation is a reaction to the changed international situation and to the desire clearly expressed by European leaders to take care of their own defense. In these circumstances, national security becomes an indispensable condition and protector of our country’s development, creating conditions for a dignified and peaceful life for Russian citizens. Methods: in order to improve legal regulation in the area of the world order, the authors identify the approaches aimed to achieving its effectiveness. This applies to the conceptual and categorical instrument, the need to introduce the special subjects on national security in the educational process. Methodological tools of the research are the complex use of activity, system, socio-cultural, civilizational and other approaches involving the ideas and provisions of the theory of state and law, political science and other areas of science. Analysis: the main research aim for the analysis of the global legal order problems is the search for socio-cultural and value-based grounds for the security of the Russian Federation. Results: during the implementation of the security proposals, there appear some difficulties posed by the new types of war (hybrid, soft, diplomatic, trade), international terrorism. Prevention of wars can be based on an effective world order. There arises the need in its deep philosophical and political legal study, with the participation of scientists and practitioners – representatives of the humane, natural, scientific, technical, military and other branches of knowledge.
FAIRNESS AS A PRIVATE LAW PRINCIPLE AND ITS EFFECTIVENESS CRITERION
Authors: GONGALO BRONISLAV , NOVIKOVA NATALIA
Published: March 2020

Introduction: the history of legal regulation is connected with the problem of fairness of legal norms (this question was raised in the politico-legal concepts of antiquity, the Middle Ages, New Era and contemporary times). Nowadays, in the context of legislative reforms and search for a balance between private and public interests, the question of fairness has not lost its significance. Not only legal theorists face this question, but legislator comes across it when determining the direction of the legislative deve-
lopment. The same question arises when law enforcer has to solve certain legal dispute. The main goal of this research is to determine the value of fairness in the private-law regulation of social relations.

Methods: the systematic analysis of the «fairness» category in the aspect of its impact on the modern state of private-law regulation acts as a determining method of the research. This particular method was chosen because it allows revealing the integrity and complex nature of the category under study. Apart from the systematic analysis, during the research general scientific dialectical method of cognition and special methods of investigation (formally legal, comparative law research, method of legal modeling) were also used.

Analysis: in the framework of study the main tendencies of private law development in the modern economic and political conditions from the perspective of general legal and private-law approaches have been investigated, inter alia the issue of searching the balance in private and public, personal and common interests in various scopes of private law application.

Results: the authors come to the conclusion that the category of fairness is multidimensional. On the one hand, it can serve as a private law principle that stems from the extensive principle of law fairness, and, on the other hand, being the reflection of social compromise, should serve as a criterion of the effectiveness of the private-law regulations on the national and international level.
CIVIL REGULATION OF THE HOUSING RELATIONS AND THE PRINCIPLE OF SOCIAL EQUITY
Authors: BANDO MIKHAIL
Published: March 2020

Introduction: the article is devoted to the problem of realization of the principle of social equity in the rules regulating housing relations. This problem is very relevant for the modern Russian society in which the housing problem is not solved. Though legal mechanisms in these relations also depend from economic but high-quality legal regulation also plays a serious role. The research objective is to check the hypothesis of existence of the principle of social equity in the Russian law, its involvement in regulation of the housing relations and insufficient realization on the example of some institutes.

Methods: the research is based on a dialectic method, such logical methods as analysis, synthesis, deduction and also a system method.

Analysis: there is a reasoning about existence of the principle of legal certainty in legal regulation and also the principles which are caused by essential qualities of the adjustable relations in the research. One of such principles is the principle of social equity. Its manifestation in regulation of the housing relations is analyzed. It is established that though this principle isn’t enshrined directly in the text of the law but it is implemented in court practice. In the housing law this principle is closely connected with category «the right to adequate housing». The need for the housing as a condition of physical existence of a person and the need for the housing of the quality providing the social dignity of a person are analyzed. The institute of rent of social housing along with the property can serve as the appropriate instrument of providing people with adequate housing, but isn’t deprived of essential shortcomings.

Results: specific civil regulation of the housing relations does not fully consider the principle of social equity. Shortcomings of the institute of rent of social housing are revealed and also options of mitigation of these shortcomings (use of mechanisms of the tort liability and a so-called judicial penalty) are offered.
The relationship between expressed emotion and temperament traits in caregivers of schizophrenic patients
Authors: MEMİŞ Çağdaş Öykü , DOĞAN Bilge , BULUT Müge , ŞAİR Yaşan Bilge , SEVİNÇOK Levent
Published: March 2020

INTRODUCTION: In the present study, we were primarily interested in determining whether some temperamenttraits of the caregivers would be associated withtheir expressed emotion levels. We also examined the relationship of EE levels of the caregivers with some care and illness characteristics of the patients.
METHODS: Seventy-six consecutive schizophrenic patients (aged between 18 and 65) according to the Psychotic Symptoms module of the Structured Clinical Interview for DSM-IV Axis I Disorders Patient Edition (SCID-I/P, Version 2.0) and their primary caregivers who had no current DSM-IV diagnoses of schizophrenia, bipolar disorder, major depression, and any anxiety disorders were included in the study. Expressed Emotion Scale, Temperament Evaluation of Memphis, Pisa, Paris and San Diego auto-questionnaire (TEMPS-A), Positive and Negative Syndrome Scale, The Calgary Depression Scale for Schizophrenia tools were used for evaluation during study.
RESULTS: The total and criticism/hostility subscale scores of EES were significantly correlated with depressive (r=0.35, p=0.002; r=0.36, p=0.001, respectively), cyclothymic (r=0.26, p=0.019; r=0.26, p=0.022, respectively), hyperthymic (r=0.28, p=0.014; r=0.26, p=0.022, respectively), and anxious temperament traits (r=0.31, p=0.006; r=0.30, p=0.007, respectively). Irritable temperament scores had a significant association with total EES scores (r=0.23, p=0.037). We have found that duration of the illness and patient care had significant inverse associations with total (r= -0.24, p=0.03;r= -0.29, p=0.009, respectively) and warmth subscale scores of EES (r= -0.34, p=0.002; r= -0.31, p=0.006, respectively). Depressive (β=0.287, t=2.737, p=0.008) and hyperthymic temperaments (β=0.223, t=2.138, p=0.036), and duration of patient care(β= -0.268, t= -2.609, p=0.011) were significantly associated with improved expressed emotion scores.
Toplinska stabilnost i plinoviti produkti razgradnje goveđe kože za izradu vatrogasne čizme
Authors: Flinčec Grgac Sandra , Žuvela Bošnjak Franka , Valečić Boris , Akalović Jadranka
Published: March 2020

U radu su ispitana svojstva otpornosti na zapaljenje i širenje plamena dvaju uzoraka vatrootpornih goveđih koža te njihova otpornost na djelovanje topline uz praćenje plinovitih produkata koji se javljaju prilikom toplinske razgradnje. Uzorci su podvrgnuti termogravimetrĳskoj analizi (TGA) uz praćenje plinovitih produkata razgradnje (TG-IR) tĳekom
dekompozicĳe. S obzirom na rezultate gorivosti zaključeno je da ispitivani uzorci glatke goveđe kože pokazuju zadovoljavajuću stabilnost
na djelovanje plamena i topline, dok je perforirana brušena vatrootporna koža s umjetnim licem djelomično pougljenila i skupila se u
području neposrednog dodira s plamenom. Oba uzorka pokazuju slično ponašanje tĳekom TGA, no razlike su uočene prilikom analize plinovitih produkata razgradnje.