bluuebunny/crossref_metadata_2025 huggingface dataset:
Karakteristik Penyakit Serebrovaskular Akut Pada Pasien COVID-19 Di Rumah Sakit Mardi Rahayu Kudus
Authors: Kristiawan Ivan Agusta Dwi , Lie Milka Ardena Lianto , Yudiarto Fenny Lanawati
Published: February 2023

Pendahuluan: Sejumlah penelitian melaporkan pada penderita Coronavirus Disease 2019 (COVID-19) selain bermanifestasi pada kelainan di saluran napas dapat juga menyebabkan beberapa manifestasi neurologi, termasuk penyakit serebrovaskular akut. Penyakit serebovaskular akut pada COVID-19 dikaitkan dengan manifestasi dan keluaran yang lebih buruk oleh karena itu dari studi ini Penuis ingin mempelajari karakteristik penyakit serebrovaskular akut pada pasien COVID-19. Tujuan dari penelitian ini adalah untuk mempelajari karakteristik penyakit serebrovaskular akut pada pasien COVID-19. Metode: Penelitian ini merupakan penelitian retrospektif observasional senter tunggal dengan peninjauan rekam medis elektronik maupun fisik pasien konfirmasi COVID-19 yang dirawat di Rumah Sakit Mardi Rahayu Kudus periode 1 Maret 2020 hingga 31 Maret 2021. Data-data yang diambil kemudian akan diuji statistik dengan uji uji χ2 dan Kolmogorov-Smirnov untuk variabel kategorik dan uji Mann-Whitney untuk variabel numerik. Hasil: Dari 1053 kasus pasien konfirmasi COVID-19 yang diteliti terdapat 50(4.7%) kasus penyakit serebrovaskular akut. Pada pasien dengan penyakit serebrovaskular akut memiliki umur yang lebih tua (57.5 (34-78) tahun vs 52 (1-88), p=0.02), memiliki komorbid hipertensi (39(78%) vs 357(35.5%), p <0.01), diabetes 31(62%) vs 383(38.2%), p=0.01), dan penyakit serebrovaskular sebelumnya yang lebih tinggi (11(22%) vs 8(0.8%), p=0.028), manifestasi klinis yang lebih berat (32(64%) vs 379(37.8%, p<0.01), dan keluaran yang lebih buruk (22(44%) vs 218(21.7%), p=0.01). Kesimpulan: Penyakit serebrovaskular pada penderita COVID-19 memiliki manifestasi klinis dan keluaran yang lebih buruk, sehingga manajemen klinis pada pasien ini sebaiknya dilakukan dengan lebih berhati-hati.
Penanganan Diabetes Sebagai Upaya Mencegah Keparahan COVID-19
Authors: Loe Luse , Soewito Ferius
Published: February 2023

Corona Virus Disease (COVID)-2019 saat ini menjadi masalah kesehatan utama di seluruh dunia termasuk di Indonesia. Kasus COVID-19 pertama ditemukan di Indonesia tanggal 2 Maret 2020 sebanyak 2 kasus hingga 7 Agustus 2022 mencapai 6.244.978 kasus dengan jumlah kematian sebanyak 157.095 kasus. Tingginya tingkat penyebaran kasus, manifestasi klinis yang sangat beragam, morbiditas dan mortalitas yang disebabkan oleh COVID-19 menimbulkan perhatian khusus bagi para klinisi mengenai faktor-faktor yang dapat menyebabkan seseorang menjadi rentan terhadap COVID-19 dan faktor apa saja yang berkaitan dengan derajat keparahan penyakit tersebut. Indonesia memiliki Case Fatality Rate (CFR) yang lebih tinggi daripada rata-rata CFR di dunia. Kasus meninggal dunia COVID-19 di Indonesia dialami oleh pasien dengan komorbid. Komorbid terbanyak yang didapatkan adalah diabetes melitus (DM).
Overview of Post-COVID-19 Multisystem Inflammatory Syndrome in Children
Authors: Prawira Yogi , Nicodemus Nicodemus
Published: February 2023

Infeksi Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) yang menyebabkan pandemi coronavirus disease of 2019 (COVID-19) pertama kali dilaporkan pada bulan Desember 2019. Sejak saat itu, berbagai negara mulai melaporkan adanya populasi anak yang dirawat dengan klinis demam persisten, renjatan kardiovaskuler, dan manifestasi hiperinflamasi multisistem pasca infeksi SARS-CoV-2 yang menyerupai sindrom renjatan toksik atau pun penyakit Kawasaki. Terminologi yang digunakan oleh Royal College of Paediatrics and Child Health (RCPCH) untuk kondisi klinis tersebut yaitu Pediatric Inflammatory Multisystem Syndrome Temporarily Associated with SARS-CoV-2 (PIMS-TS), yang selanjutnya lebih dikenal sebagai Multisystem Inflammatory Syndrome in Children (MIS-C) sesuai Centers for Disease Control (CDC) dan World Health Organization (WHO). Spektrum klinis, derajat berat, dan gejala MIS-C sangat beragam dengan gejala yang paling sering dilaporkan adalah demam persisten (97-100% pasien), bersamaan dengan manifestasi klinis pada sistem gastrointestinal (70% pasien), kardiovaskular, dan atau dermatologis. Hingga saat ini, patogenesis yang mendasari terjadinya MIS-C belum diketahui secara pasti. Tatalaksana kasus MIS-C memerlukan kolaborasi multidisiplin ilmu. Konsensus maupun pedoman baku untuk tata laksana MIS-C belum disepakati para ahli, namun secara umum terapi awal meliputi pemberian imunoglobulin intravena (IVIG) dan kortikosteroid.
Keterbatasan Metode Diagnostik Patologi Anatomik dalam bidang Transplantasi Ginjal di Indonesia
Authors: Saraswati Meilania , Hustrini Ni Made , Purnama Yoel
Published: February 2023

Keterbatasan Metode Diagnostik Patologi Anatomik dalam bidang Transplantasi Ginjal di Indonesia
Hubungan Lemak Tubuh Dan Volume Hematoma Stroke Perdarahan Intraserebral
Authors: Muliawan Eudon , Kembuan Mieke Actress Hanna Nelly , Tumboimbela Melke Joanne
Published: February 2023

Pendahuluan: Persentase lemak tubuh (%LT) dapat dengan mudah dan akurat diprediksi dengan pengukuran tebal lipatan kulit. Sehingga distribusi, hubungan, dan prediksinya terhadap volume hematoma pasien stroke perdarahan intraserebral (PIS) menarik untuk di teliti. Metode: Suatu penelitian potong lintang analitik terhadap subjek dengan stroke PIS di RSUP Prof. Dr. R. D Kandou Manado, Indonesia yang memenuhi kriteria penelitian secara konsekutif diukur ketebalan lipatan kulit tubuh kemudian dikonversi menjadi %LT dan estimasi volume perdarahan dengan metode ellips diperiksa dengan analisis regresi linear.Hasil: Sebanyak 165 sampel (87 laki-laki) rerata usia 53 tahun. 65% sampel memiliki %LT >25% (median 27,8%). Lebih dari 50% laki-laki memiliki %LT >25%, sedangkan 60% perempuan memiliki %LT >30% (p<0,001). Median volume hematoma stroke PIS sebesar 20,5mL (IQR 8,6−43,2mL). Terdapat peningkatan volume hematoma PIS terutama pada laki-laki dengan %LT > 30%. Pada kelompok ini setiap kenaikan %LT akan meningkatkan volume hematoma stroke PIS sebesar 22,34mL (95% CI 5,15−39,52mL; p=0,011).Kesimpulan: Terdapat hubungan bermakna antara %LT yang dinilai dengan ketebalan lipat kulit dengan volume hematoma stroke PIS pada penelitian ini, kenaikan volume tampak jelas khususnya pada laki-laki dengan %LT diatas 30%.
Comparison of Regular Rehabilitation Program with Additional Reciting Holy Qur’an on Cardiorespiratory Fitness among Covid-19 Survivors
Authors: Pane Rita Vivera , Donastin Adyan , Al Hajiri Aufar Zimamuz Zaman
Published: February 2023

Introduction: Rehabilitation program has been proven to be able to restore the cardiorespiratory function of Covid-19 survivors. Reciting Holy Qur’an are associated with a more relaxed and lowered heart rate of the reciter. The present study aims to compare the regular rehabilitation program with addition of Reciting Holy Qur’an on cardiorespiratory fitness among moslem Covid-19 survivors. Method: This quantitative experimental study involved 18 moslem patients who were assigned into two groups. Eight patients in the interventional group received additional Qur’an recitation every day at least 20 pages, divided into several sessions according to the participants’ ability and opportunity. Meanwhile, ten patients in the control group received regular rehabilitation programs with mild to moderate intensity. The cardiorespiratory fitness level was evaluated by a count test (CT), incentive spirometry test (IST), and a 6-minute walk test (6MWT). The measurement was performed three times: before intervention, the first week, and the second week after treatment. Result: The participants were eight males and ten females with an age average of 51.9 ± 9.5 years. Both groups showed significant differences before and after treatment in the first and second week in terms of CT, IST, and 6MWT (p <0.05). There was a significant difference between the two groups in the first week in the IST result (p < 0.05), no significant difference in the second week was noticed. Conclusion: The Covid-19 survivors receiving additional Holy Qur’an recitation exhibit faster cardiorespiratory fitness improvement than the control group.
Rhabdomyolysis in Thyroid Crisis
Authors: Soetedjo Nanny Natalia Mulyani , Loe Luse , Kusumawati Maya , Ritonga Ervita , Permana Hikmat
Published: February 2023

Pendahuluan: Kondisi rhabdomiolisis dengan krisis tiroid sangat jarang terjadi, di dunia hanya ada terdapat 7 laporan kasus. Kasus ini merupakan kasus kedelapan yang dilaporkan. Laporan Kasus: Laporan kasus mengenai seorang laki-laki 46 tahun dengan Graves’ Disease yang datang dengan krisis tiroid dan rhabdomiolisis. Diskusi: Pasien datang dengan sesak dan jantung berdebar-debar sejak 10 jam sebelum masuk RS ada takikardi (160 kali/menit), takipnea (26 kali/menit), pembesaran tiroid, kelemahan motorik, ronki basah kasar paru bilateral dengan Burch-Wartofsky Point Scale: 60 dan Japan Thyroid Association: TS2 first combination. Laboratorium menunjukkan peningkatan hormon tiroid fT4 >5.0, TSHs: 0.06 uIU/ml, positif TRAb dan Anti TPO, hiperkalemia (7.7 meq/L), ureum 144 mg/dl, kreatinin 1.92 mg/dl, peningkatan creatine kinase (CK) 3645 U/L. Pasien diterapi dengan tatalaksana krisis tiroid (propiltiourasil, lugol, dexamethasone) dan terapi tambahan (dobutamin, digoksin, furosemide, antibiotika, terapi hiperkalemia). Pasien pulang setelah 11 hari perawatan dengan resolusi klinis dan perbaikan kadar CK, ureum, dan kreatinin.Kesimpulan: Hipertiroid dapat menyebabkan rhabdomiolisis. Kondisi ini perlu diwaspadai dan menjadi diagnosis banding pada rhabdomiolisis non traumatik yang disertai gangguan ginjal akut, sehingga penatalaksanaan dapat dilakukan lebih cepat dan baik.
Aspek Psikoendokrinoneuroimunologi pada Patogenesis Diabetes Mellitus Tipe 2
Authors: Setiani Ariana , Maharatih Gusti Ayu , Kartodarsono Supriyanto
Published: February 2023

Diabetes merupakan penyakit kronis yang termasuk dalam sepuluh penyebab kematian tertinggi di seluruh dunia. Patogenesis DM 2 melibatkan mekanisme kompleks pada berbagai organ. Kondisi psikis termasuk stres, cemas, dan depresi dinilai berhubungan timbal balik dengan terjadinya ganggua regulasi glukosa. Sebaliknya kondisi hiperglikemia pada individu DM 2 dapat memicu munculnya berbagai permasalahan psikis. Gangguan psikis kronis dapat memicu aktivasi HPA aksis, meyebabkan peningkatan kadar kortisol dan menghambat mekanisme umpan balik pada aksis tersebut. Aktivasi sistem saraf simpatis, jalur inflamasi dan stres oksidatif, metabolisme triptofan serta disbiosis mikrobiota dalam usus juga merupakan faktor yang terlibat pada keterkaitan antara patologi regulasi glukosa dan gangguan psikologis. Keseluruhan faktor tersebut saling terkait membentuk lingkaran setan yang menyebabkan progresivitas serta munculnya komplikasi pada DM 2.
Domain Stresor dan Hubungannya dengan Stres pada Mahasiswa Kedokteran di Masa Pandemi Covid-19
Authors: Prasetyo Juan Alexsandra , Hidayat Jenny , Surilena Surilena , Widjaja Nelly Tina
Published: February 2023

Pendahuluan: Mahasiswa kedokteran merupakan populasi yang rentan untuk mengalami masalah kesehatan mental pada masa pandemi Covid-19. Selama proses pendidikan, terdapat beberapa domain stresor yang berpotensi menyebabkan stres.

Metode: Studi potong lintang dilakukan terhadap 796 mahasiswa kedokteran preklinik dan klinik Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Katolik Indonesia Atma Jaya. Alat ukur penelitian terdiri atas kuesioner karakteristik responden, kuesioner MSSQ untuk mengukur domain stresor, dan kuesioner DASS-21 untuk mengukur stres. Analisis data dilakukan secara univariat, kemudian bivariat dengan uji korelasi Rank Spearman.

Hasil: Persentase stres pada responden didapatkan sebesar 48,7%. Domain stresor yang menyebabkan stres tingkat berat adalah stresor akademik, belajar-mengajar, dan aktivitas grup. Domain stresor yang menyebabkan stres tingkat sedang adalah stresor hubungan interpersonal dan intrapersonal, sosial, serta dorongan dan keinginan. Stresor yang banyak dijumpai pada responden adalah stresor akademik. Stres didapatkan pada 52,8% responden perempuan dan 40,2% responden laki-laki. Stres didapatkan pada 53,0% mahasiswa preklinik dan 37,0% mahasiswa klinik. Terdapat korelasi positif bermakna antara seluruh domain stresor dengan stres (p <0,01, rs = 0,387 – 0,481).

Kesimpulan: Terdapat hubungan bermakna antara seluruh domain stresor dengan stres pada mahasiswa kedokteran.
Peptida Antimikrobial Cathelicidin dan Hubungannya terhadap Vitamin D dalam Masa Pandemi COVID-19
Authors: Devana Natasha Dianasari , Mudjihartini Ninik
Published: February 2023

Peptida Antimikrobial (PAM) merupakan peptida yang memiliki sifat proteksi terhadap mikroba berupa bakteri, jamur maupun virus. Kemampuan untuk membunuh patogen secara langsung menjadikan PAM sebagai salah satu mekanisme pertahanan dari tubuh, sehingga PAM saat ini juga dikenal sebagai Host Defense Protein (HDP). Cathelicidin merupakan salah satu jenis PAM pada manusia yang diketahui memiliki fungsi proteksi khususnya terhadap sel-sel respiratori yang merupakan sasaran utama virus SARS CoV-2 penyebab COVID-19. Kinerja PAM cathelicidin merepresentasikan aktivitas lini pertama dari imun sistem alamiah dimana sintesis cathelicidin berkaitan dengan kecukupan kadar vitamin D. Sejumlah penelitian terdahulu menemukan hubungan kadar vitamin D yang rendah dengan kadar cathelicidin yang rendah, hal ini memberikan gambaran pentingnya memperhatikan kadar vitamin D dalam meningkatkan sistem imun alamiah khususnya untuk sintesis cathelicidin sebagai dasar pertahanan tubuh dalam masa pandemi COVID-19.
Ảnh hưởng của chiều sâu khóa đến khả năng chịu cắt của khóa chống cắt đơn trong cấu kiện lắp ghép phân đoạn bê tông cốt thép dự ứng lực
Authors: Nguyễn Đắc Đức , Nguyễn Ngọc Long , Trần Đức Nhiệm , Hoàng Nhật Minh
Published: February 2023

Kết cấu nhịp cầu dầm lắp ghép phân đoạn được hình thành từ các khối đúc sẵn. Các khối này liên kết với nhau tại vị trí mối nối nhờ cáp dự ứng lực, khóa chống cắt và keo liên kết. Khả năng chịu mô men của mặt cắt tại vị trí mối nối nhờ vào cáp dự ứng lực và khả năng chịu nén của bê tông được tính toán như kết cấu bê tông cốt thép dự ứng lực chịu uốn thông thường. Tuy nhiên, vị trí mối nối không bố trí cốt thép thường và cốt thép đai do đó khả năng chịu cắt của mối nối phụ thuộc vào khả năng chịu cắt của bản thân khóa chống cắt, ma sát phần tiếp xúc phẳng và thành phần tham gia của cốt thép dự ứng lực nếu có. Điều này đã được chỉ ra bởi rất nhiều nghiên cứu thực nghiệm, mô phỏng và thể hiện trong các Tiêu chuẩn tính toán thiết kế như AASHTO, DIN, EURO CODE, BS...trong đó khả năng chịu cắt của bản thân khóa chống cắt chiếm tỷ trọng đáng kể. Khả năng chịu cắt của khóa không chỉ phụ thuộc vào cường độ bê tông, chiều cao khóa mà còn phụ thuộc rất lớn vào chiều sâu khóa. Nhiều nghiên cứu đã được thực hiện nhằm đưa ra công thức tính khả năng chịu cắt của bản thân khóa cũng như mối nối tuy nhiên mới thực hiện trên một hoặc một số kích thước khóa cụ thể do đó không phản được ảnh hưởng của chiều sâu khóa đến ứng xử chịu cắt của bản thân khóa. Bài báo tập trung khảo sát khả năng chịu cắt của một khóa chống cắt đơn không bố trí cốt thép và có bố trí cốt thép khi thay đổi chiều sâu khóa trong khi chiều cao khóa không đổi để xác định chiều sâu khóa hợp lý nhằm góp phần hoàn thiện công tác thiết kế cũng như khai thác bảo dưỡng kết cấu cầu dầm bê tông cốt thép lắp ghép phân đoạn.
Nghiên cứu ảnh hưởng khi vận hành thiết bị cơ khí tới rung động đất nền
Authors: Nguyen Thi Cam Nhung , Nguyen Duc Binh , Nguyen Huu Quyet
Published: February 2023

Trong các khu công nghiệp, đặc biệt là các nhà máy công nghiệp cơ khí, xây dựng, việc vận hành các máy móc, thiết bị nặng phục vụ công tác gia công, sản xuất có thể gây ra những ảnh hưởng lớn đến sự ổn định trong đất nền. Việc nghiên cứu rung động trong đất nền đã nhận được nhiều sự quan tâm của các nhà khoa học cả trong và ngoài nước do tính chất quan trọng của vấn đề. Bài báo này tập trung vào phương pháp đo thực nghiệp, xử lý số liệu phù hợp để từ đó phân tích, xác định được ảnh hưởng của rung động đất nền từ hoạt động sản xuất công nghiệp tại nhà máy KVB – tỉnh Bình Dương đối với các khu vực xung quanh. Từ kết quả thu được tiến hành so sánh, đối chiếu với điều kiện thực tế và các tiêu chuẩn hiện hành liên quan để đưa ra các giải pháp đảm bảo an toàn cho những công trình lân cận. Kết quả của bài báo có thể được áp dụng một cách hiệu quả cho công tác quan trắc và đánh giá ảnh hưởng của rung động đất nền từ hoạt động sản xuất công nghiệp tới các công trình xung quanh
Nghiên cứu một số đặc tính cơ học của bê tông đầm lăn sử dụng cốt liệu lớn tái chế từ bê tông phế thải
Authors: Trần Thị Bích Thảo , Nguyễn Tiến Dũng
Published: February 2023

Bê tông tái chế là một loại vật liệu xây dựng xanh, thân thiện với môi trường và góp phần hạn chế việc khai thác tài nguyên thiên nhiên. Bê tông đầm lăn (BTĐL) sử dụng cốt liệu tái chế đã được ứng dụng thành công trong kết cấu áo đường tại một số quốc gia trên thế giới. Nghiên cứu này trình bày một số đặc tính cơ học của BTĐL sử dụng cốt liệu lớn tái chế từ bê tông phế thải (CLLTC), ứng dụng làm lớp móng đường ô tô. CLLTC được thay thế cho cốt liệu lớn tự nhiên với các hàm lượng là 0%, 30%, 50%, 75% và 100%. Thành phần vật liệu của BTĐL được thiết kế theo nguyên lý cơ học đất (độ ẩm tối ưu và khối lượng thể tích khô lớn nhất). Khi sử dụng CLLTC với hàm lượng 75% và 100%, cường độ chịu nén ở 28 ngày tuổi giảm khoảng 25-35% trong khi cường độ ép chẻ và mô đun đàn hồi giảm khoảng 20-25%. Khi thay thế 100% cốt liệu lớn tự nhiên bằng CLLTC thì BTĐL vẫn đạt được các chỉ tiêu cơ học để làm lớp móng mặt đường bê tông xi măng. Kết quả nghiên cứu là cơ sở khoa học cho việc sử dụng loại vật liệu này trong xây dựng công trình giao thông tại Việt Nam
Mô phỏng số PTHH xác định hằng số điện môi của vật liệu composite với cốt là vi cầu thủy tinh rỗng nền Epoxy
Authors: Nguyễn Thị Hương Giang , Vũ Nguyên Thành
Published: February 2023

Vật liệu Composite có cốt liệu là vi cầu thủy tinh rỗng nền epoxy rất được quan tâm nghiên cứu trong thời gian gần đây do ngoài những ứng dụng làm vật liểu nổi của hàng hải, nó còn được ứng dụng làm vật liệu mật độ thấp trong điện tử. Bài báo nghiên cứu xây dựng mô hình số PTHH để tính toán hằng số điện môi của vật liệu Composite có cốt liệu là vi cầu thủy tinh rỗng đặt trong nền epoxy (vật liệu bọt thủy tinh), khi tỉ lệ thể tích vi cầu thủy tinh biến đổi từ 0 tới 60%, độ dày thành thủy tinh và bán kính ngoài thay đổi. Mô hình số xây dựng với vật liệu tuần hoàn có nhân tử tuần hoàn là lập phương đơn giản, lập phương tâm khối, lập phương tâm mặt với sự hỗ trợ của phần mềm có mã nguồn mở Cast3m. Trên nhân tuần hoàn, các điều kiện tuần hoàn cho cảm ứng điện trường và trường điện thế vi mô được thỏa mãn. Sau đó, áp dụng tính toán cho bốn dạng hạt của vi cầu thủy tinh là K1, K20, S38HS và S60HS sản xuất tại công ty 3M China. Kết quả số đạt được so sánh với kết quả của đường bao Hashin-Strikman, với kết quả theo công thức giải tích, kết quả thực nghiệm của các nghiên cứu trước để kiểm tra độ tin cậy. Kết quả của nghiên cứu này bổ sung thêm lý thuyết tính toán, dự báo hằng số điện môi hiệu dụng của vật liệu bọt thủy tinh
Weight evaluation of factors influencing road flood risk in Mekong river delta
Authors: Thai Thi Kim Chi , Thai Thi Kim Chung
Published: February 2023

The Mekong River Delta is one of the most vulnerable areas in the world. Because of climate change, the risk of road flooding in the Mekong River Delta is increasing. Road flood disaster is considered as a series of damage processes affecting a road under the effect of different factors such as natural and social factors. Thus, index weight evaluation is a critical part in multi-index evaluation as well as road flood risk management. Some main flood-causative factors considered in this paper are road characteristics, climatic factors, hydrological characteristics, geology environmental factors and social factors. The significant criteria of road flood vulnerability are identified. The weight of different criteria was determined using the subjective method based on the Analytic Hierarchy Process (AHP). The obtained weights can be used for the flood risk evaluation and classification, providing valuable information for decision-making process in the road flood management to prevent and decrease the losses of roads during natural disaster like flooding
Phase field method with strain orthogonal decompositions for modelling of damage in heterogeneous materials obtained by X-ray computed tomography images
Authors: Vu Ba Thanh
Published: February 2023

The phase-field method has become a robust tool to describe the complex crack nucleation and propagation in heterogeneous materials. In these materials, an interaction between bulk brittle damage and interfacial damage through the splitting the strain tensor into a bulk strain part and a jump strain part at the interfaces. Moreover, the material response of the heterogeneous materials in tension and compression, the bulk strain part needs to be decomposed into a positive part and a negative part. However, most of the previous works, these decompositions do not verify the negative part be orthogonal the positive part, which lead to the inaccuracy in the material mechanical behavior. To solve the shortcomings, the strain orthogonal decompositions problem that is applied to decompose the bulk strain in our work. In the present work, author combined the phase-field modeling taking into account interfacial damage with the problem of the bulk strain orthogonal decompositions by two proposed solutions. The successful prediction of the crack propagation for the inclusion-matrix structures and the multi-phases materials of X-ray computed tomography (XR-CT) images by two proposed solutions will be demonstrated in several numerical examples.
Thermodynamic analysis of a waste heat recovery libr/H2O single effect absorption chiller system in textile in Vietnam
Authors: Van Kha Pham , Thi Thu Ha Tran
Published: February 2023

Model for energy and exergy analysis of absorption refrigeration using waste heat from textile factory has been built. The analysis that uses different models of heat exchangers are the overall heat conductance (UA) model, and the effectiveness model. The result show that the exergy loss in the generator and absorber are the larger than condenser and evaporator. Therefore, it is necessary to focus on improving these two important devices in absorption chiller. For the convenience of system operation, the research analyzed the effects of generator inlet temperature and solution pump mass flow rate on the energetic and exergetic performance of the absorption chiller. The study results indicated that the exergy efficiency of the absorption chiller decrease from 0.2776 to 0.2146 when increasing the solution pump mass flow rate from 1.5 kg/s to 2.5 kg/s and the generator inlet temperature from 80 oC to 98 oC. Meanwhile, energy efficiency will increase slightly initial from 0.769 to 0.779 and then decrease from 0.779 to 0.776 as the generator inlet temperature increases from 80 oC to 98 oC when solution mass flow rate is 1.5 kg/s. And energy efficiency decreases from 0.769 to 0.734 when the solution pump mass flow rate increase from 1.5 kg/s to 2.5 kg/s
UPIA KARANJI HOME INDUSTRY BUSINESS MANAGEMENT (KOPIAH BASKET) IN POLOHUNGO VILLAGE
Authors: Ibrahim Sindri , Latif Samin , Lakoro Fibriyanti
Published: February 2023

The purpose of this research is to find out the problems faced by the home industry business in Polohungo Village and to find out how they carry out promotional and marketing activities.

        In this study, the researcher used a descriptive type of research with a qualitative approach. The research instrument is the key instrument or the main instrument. Data was obtained by using data collection techniques in the form of observation, interviews, and documentation. For further processing using qualitative data analysis techniques that were carried out interactively.

       The results of the study concluded that Upia Karanji's Home Industry Business Management (Kopiah Basket) includes planning, organizing, actuating, and controlling.
IMPLEMENTATION BSPS PROGRAM POLICIES POVERTY REDUCTION TIBAWA DISTRICT
Authors: Dunggio Yunus , ANIS NAKI  , KARLINA NAPU
Published: February 2023

The aims of this study are: 1) to identify and analyze the implementation of bsps program policies in poverty alleviation in tibawa district; 2) to find out what are the factors that determine the success of implementing the bsps program policy in poverty alleviation in tibawa district

This study uses a research conducted using a qualitative approach while the type of research used in this thesis research is qualitative descriptive research.

The results of this study indicate that: 1) the implementation of the bsps program policy in poverty reduction in tibawa district has not run optimally. In measuring the success of the implementation of the bsps policy, it can be seen from 3 indicators, namely: a) it is seen that the planning has been carried out optimally; b) the implementation of the bsps program has been running but is not yet optimal. One of the non-optimal programs of this bsps is the absence of a clear soup. In addition, the availability of materials also affects the implementation of the bsps program. The availability of materials provided by suppliers or material stores is limited or does not match the demand for goods needed by the recipient community of the bsps program. In addition, the price of materials that are suddenly expensive so that they are not in accordance with the drpb and rab that have been made by the recipients of the bsps program; c) judging from the supervision process has been carried out properly. Supervision is carried out in a preventive and repressive manner. Preventive supervision is carried out before the start of an activity or before the occurrence of financial expenditures for bsps assistance. Meanwhile, repressive supervision is carried out by evaluating financial and operational accountability report documents. This inadequacy can be seen from the fact that there are still some people who do not fully understand and utilize the bsps assistance funds according to their designation; 2) the factors that determine the implementation of the bsps program policy in poverty reduction in tibawa district consist of resources, communication, and disposition
Packaging Design for OTOP Products: a Case Study of CHALARE Community Enterprise, Singhanakhon, Songkhla
Authors: Chanintornsongkhla Mongkol , Moogem Surawat , Phromprawat Pranrafa
Published: February 2023

This study was aimed to (1) investigate, survey, and collect the data of OTOP products and identity of Chalare Community and (2) to design packaging for OTOP products of Chalare Community Enterprise, which represent the community’s identity. The data were collected using structured interview with 30 OTOP producers selected by purposive sampling. The data were managed and analyzed into two parts. (1) The physical data were collected from the survey and photographing to describe the identity of OTOP products in Chalare Community. (2) The data from the interview were collected and concluded to be a guidance for packaging design. The result of this study indicated that (1) the identity of Chalare Community represents the agricultural community located along Songkhla Lake around Chalare Temple Hills. Most of the people in the community are Buddhist and do some farming and Palmyra Palm planting to earn their living. In addition, (2) the packaging design of the products is separated into two groups: group A packages for sugar palm products, and group B packages for fresh sugar palms with honey-mixed lemon juice and fresh sugar palms with plum juice. In terms of branding, the packages in both groups are branded with the word “Not Na Lare” which was designed in a smiling-curve shape.
The Learning Development Process and Capacity Enhancement for Ethnic Children and Youth in The Northern
Authors: Prasopsombat Ladda
Published: February 2023

The research subject, The Learning Development Process and Capacity Enhancement for Ethnic Children and Youth in The Northern Region has the following objectives; 1. To promote and develop the learning process for children and youth, children and youth groups. 2. To support ethnic children and youth groups to have the opportunity to use their potential to create new activities to benefit the community. 3. To assess the implementation of learning management and capacity building for ethnic children and youth in the northern region. In this study, target groups were selected to study the learning development process of children and youth through the operation of 2 organizations, namely the Education for Life and Society Foundation and Ya Phraek Salawin group. The two organizations worked with school teachers, community leaders, children and youth. In this study, qualitative data were collected from interviews with teachers, staff of local organizations, community leaders and other stakeholders. The results showed that a child and youth work process was created through the management process by coaching in the learning development process and the use of empowerment methods is a process of developing capacity. There was an empowerment to see the creative power for youth and themselves. “Youth led, adults supported” and the assessment of the work found that both organizations focused on knowledge management that creates the power of change, discovery of children and youth as well as knowledge in working that creates change and solves problems for children and youth
Nora Bead Crafting in Nakhon Si Thammarat, Thailand: A Cultural Reproduction for Sustainability
Authors: Kamlangkuea Thachamon , Yussayotha Amnouy
Published: February 2023

The Nora show started in 1820, using Nora beads to decorate the Nora costumes. Today, Nora beads are created as crafts for ornament in response to the needs of society and consumers. However, due to the changes affecting the social and economic aspects, the preservation and maintenance of crafts like Nora are crucial for sustainability. This article, which is part of a larger study on “Nora Bead Crafting: Cultural Capital and Creative Folklore”, is designed as analytical descriptive research with qualitative data analysis. The data for this study was collected using in-depth interviews and focus group discussions participated by Nora bead crafters in Muang District, Nakhon Si Thammarat Province. The findings revealed that Nora, a local performing art of the Southern part of Thailand, preserved and maintained the Nora identity and numerous belief systems. The crafters designed their products by changing the colours, shapes, and patterns and using the materials in stringing or embroidering the beads. The creation of the Nora beads in these new ways is considered a reproduction of culture in four aspects—production, dissemination, consumption, and reproduction.
Review on Good Laboratory Practices
Authors: Salgar J. B.  , Bais S. K .  , Teli A. S
Published: February 2023

They Are Mainly Intended For Them Laboratories Conducting Studies Have Good Laboratory Practices (GLP) As a result, it can help to preserve a concern for human and environmental fitness and pave the way for a reasonable understanding of scientific challenges. Around this investigation, we have made an effort to investigate the applications of GLP principles in other scientific fields, their acceptability, and potential financial rewards. adherence to regulations. To fulfil the needs of experimental aims, the age of high-quality data, and assay reproducibility, GLP may now be applied to a wide range of scientific domains. Given its importance, it is now accessible in administrative settings, enterprises, and educational institutions all around the world. GLP is a promising strategy for enhancing the reliability and repeatability of examination data, which facilitates universal acceptance. The time has come to summarise and put into practise the GLP vision beyond regulatory inquiries. Presented Era Of Rapidly And Developing Technology And Evidence Based Treatment, Good Laboratory Practice (GLP) Shall Play An A Significant Position In Assuring, Thickness, Trustworthiness, Reproducibility And Quality Of Laboratory Examinations. (1).
Transversal Reasoning on Chessed
Authors: Hasselaar Jan Jorrit
Published: February 2023

This chapter continues transversal reasoning (TR) with a conversation
on chessed between Jonathan Sacks and the economist Samuel Bowles,
and between Sacks and Bart Nooteboom on the governance of chessed.
The reason for this TR is to explore its relevance for a social response
to radical uncertainty in the context of climate change. TR on chessed
indicates other-regarding motives, besides self-interest, for dealing with
radical uncertainty in the context of climate change. People inspired
by chessed learn to take responsibility together, bottom-up and in the
present, for a shared future. The plurality among those involved is crucial
for opening up the identities people are living by in order to create a
new ‘we’. This new ‘we’ is not only between humans, but also between
humans and non-humans. Joy appears as one of the results of building
relationships inspired by chessed. TR points out that there are also negative
other-regarding motivations and that seemingly positive motivations can
slip into negative ones. This raises the question of whether it is possible
to govern positive motivations. To answer this question, TR turns to a
conversation between Sacks and Nooteboom. This conversation highlights
the role of the covenant in governing positive other-regarding motivation
on a micro- and macro-scale. It is argued that, in a social response to
radical uncertainty in the context of climate change, the covenant can be
supported by, and help to flesh out, competition (market) and hierarchy
(government).
Conclusions
Authors: Hasselaar Jan Jorrit
Published: February 2023

This chapter concludes the study with a summary of the main conclusions
of transversal reasoning (TR) between Jonathan Sacks and the economists
Bart Nooteboom, Samuel Bowles, Dan Ariely and John Kay & Mervyn King.
The relevance of TR is that it presents and deepens alternative critical
assumptions for the ones underlying conventional economic modelling, in
particular the social cost-benefit analysis (SCBA), in order to develop more
properly a social response to radical uncertainty in the context of climate
change. The study shows that Wentzel van Huyssteen’s postfoundational
approach allows a rather successful conversation between theology and
economics. To conclude the postfoundational approach, the chapter answers
the question of what both disciplines can learn from TR employed here.
Finally, limitations and recommendations for further research are presented.
Botanical Barbary : Punning, Race, and
Plant Life in Othello 4.3
Authors: Nunn Hillary M.
Published: February 2023

The barberry plant never appears in Othello, but its resonances in Act 4
Scene 3 crystalize the play’s concerns with racial status, women’s domestic
knowledge, and European beauty standards. Scholars have begun to
consider the scene’s global context, concentrating on Desdemona’s revelations
about her mother’s servant, Barbary. Yet Barbary’s name also
conjures images of the more familiar barberry bushes of England, which
proved common in recipes for lightening hair. The scene’s invocation
of the barberry plant underscores the play’s concerns with culturally
determined notions of beauty and the potential for “fair” outsides to mask
unchaste interiors. In considering barberries beside Barbary, this essay
sheds new light on the play’s anxieties regarding racial categorizations,
beauty, and female virtue.
“Circummured” Plants and Women in
Measure for Measure
Authors: Duncan Claire
Published: February 2023

Measure for Measure’s “garden circummured with brick” (4.1.25) resembles
early modern horticultural discourse that urges gardeners to try to enclose
the feminized generativity of Nature. Yet, as the play repeatedly shows,
fertility is not so easy to control. Mariana and Isabella prove indistinguishable
to Angelo, and it is Mariana who is, in Angelo’s words, “a deflowered
maid” (4.4.20). This essay argues that the bed trick’s garden location and
Angelo’s floral metaphor enact a slippage between human and plant: the
bed trick becomes a flower-bed trick. Using an ecofeminist lens, I contend
that Isabella’s (and Mariana’s) transformation into plant matter creates
female-horticultural bodies that can resist as women with autonomy over
their sexualized bodies and as plants that elude human control.
The Botanical Revisions of 3 Henry VI
Authors: Hogue Jason
Published: February 2023

This analysis investigates the differences in botanical representation
between the version of 3 Henry VI printed in the 1623 First Folio and the
earliest printed version of the play, the 1595 octavo The True Tragedy. This
comparison of textual variants demonstrates that the botanical stylings
of the folio text are considerably more extensive and elaborate than those
of the octavo. These changes range from added passages to single-word
variants, suggesting a comprehensive program of revision aimed toward
expanding the botanical register of the play. Botanical revisions to the
text also point toward an attempt at harmonizing the play with others in
the first history tetralogy, giving it a more serial and connected character
when grouped among other history plays in the First Folio.
Data as Boundary Objects,
Datafication as Boundary Work
Authors: Leurs Koen
Published: February 2023

In this chapter, I argue the twin concepts of the “boundary object” and
“boundary work” (Star 2010) enable researchers to tease out how the
datafication of governance and bureaucracy results in inclusion and
exclusion. The concept of boundary work enables us to ask how, for
whom, for what purposes, and in what circumstances data are created,
collected, categorized, used, and processed. The concept of the boundary
object invites us to scrutinize the tangible records of datafication such as
categories, units, numbers, and symbols by asking what forms of inclusion
and exclusion they maintain or challenge. In the chapter, I explore the
analytic potential of these concepts by comparing historical analogous
and contemporary digitized bureaucratic governance of human mobility.
The case of historical Surinamese slave registers and the contemporary
Dutch passport show the urgency of questioning taken-for-granted
intersectional power relations between boundaries and datafication.
Future research may explore further how datafication benefits some,
hurts others, materializes in particular data objects, and reflects particular
situated (historical) contexts.
Early and delayed suture adjustments after adjustable suture strabismus surgery: a randomized controlled trial
Authors: Abdelmonem Ahmed Adel , Awadein Ahmed , Genidy Mahmoud Mohamed M , Abdelhalim Ahmed Shawkat , Abdelaziz Sahar Torky A
Published: February 2023

Background: Adjustable sutures increase the success rate of strabismus surgery. However, the optimal timing of postoperative suture adjustment remains controversial. This trial was aimed at comparing the surgical outcomes and pain scores of early or 2 – 4 h and delayed or 24 h postoperative suture adjustment in adult patients undergoing strabismus surgery.

Methods: An open-label, prospective, randomized, comparative interventional study was performed in consecutive adult patients scheduled for eye muscle surgery. Patients were randomized into two groups: the early group, with suture adjustment 2 – 4 h postoperatively, and the delayed group, with suture adjustment 24 h postoperatively. Subjective pain scores during the adjustment were also analyzed. The angles of misalignment at 1 and 3 months and the success rate at 3 months postoperatively were compared.

Results: Forty-five (90%) patients completed the follow-up, including 23 (92%) in the early adjustment group and 22 (88%) in the delayed adjustment group, with a mean (standard deviation) age of 25.6 (9.5) years and a male-to-female ratio of 46.7:53.3. Thirty patients (66.7%) had exotropia, and 15 (33.3%) patients had esotropia. Both groups had comparable baseline characteristics (all P > 0.05). The mean pain scores during adjustment did not differ significantly between groups (P > 0.05). The postoperative angles of alignment were comparable between the groups before suture adjustment and at the 1- and 3-month follow-ups (all P > 0.05). The success rate in the early adjustment group was slightly higher (87.0% versus 63.6%), but the difference was not statistically significant (P > 0.05). The success rate was comparable between the groups in patients with esotropia or exotropia (both P > 0.05).

Conclusions: Although the early adjustment group had a slightly higher success rate, the difference was not significant. Both groups had comparable subjective pain scores during adjustment. Future clinical trials should be performed different time intervals for postoperative suture adjustment, and subjective and objective outcomes, such as diplopia and stereopsis, should be compared between patients with a first strabismus surgery and those who underwent reoperation. This could better resolve the persistent controversy related to the optimal time for suture adjustment.
Association of the serum chemerin level with the development of diabetic retinopathy in patients with type 1 diabetes mellitus
Authors: Elmahdy Ahmed Gomaa , Ibrahim Mohamed Mohamed-Aly , Salama Omar Hassan , Ziada HossamEldinAbdelmonem , Ali Mahmoud Mohammed , Elmohaseb Ghada F , Youssef Eman MI , Bayoumy Eman Saad , Bayomy Marwa Ahmed , Mohamed Sanaa Ahmed
Published: February 2023

Background: In patients with type 2 diabetes mellitus, the development of diabetic retinopathy (DR) correlates positively with elevated serum chemerin levels. This study was aimed at investigating the probable association between the serum chemerin level and the development of DR in patients with type 1 diabetes mellitus (T1DM).

Methods: In this cross-sectional study, we included Egyptians and classified them into four groups: group 1, including healthy individuals; group 2, including patients with T1DM without DR; group 3, including patients with T1DM with non-proliferative DR (NPDR); and group 4, including patients with T1DM with proliferative DR (PDR). The assessment included best-corrected distance visual acuity assessment, slit-lamp biomicroscopy, funduscopy, fundus fluorescein angiography, and macular ocular coherence tomography. Fasting blood samples were obtained from all participants to measure serum chemerin, glycated hemoglobin (HbA1c), total cholesterol, triglyceride, and creatinine levels. Serum chemerin levels were compared among the groups, and their correlations with age, duration of diabetes, HbA1c, total cholesterol, triglyceride, and creatinine levels were analyzed.

Results: We recruited 209 participants, including 46 healthy individuals in group 1, 52 patients (T1DM and no DR) in group 2, 61 patients (T1DM and NPDR) in group 3, and 50 patients (T1DM and PDR) in group 4, with comparable mean ages and sex ratios among groups. The diabetes duration, body mass index, HbA1c, total cholesterol, triglyceride, and serum chemerin levels differed significantly among the groups (all P < 0.001), whereas the creatinine level did not (P > 0.05). The serum chemerin level was significantly higher in group 4 than in groups 3 and 2, in group 3 than in group 2, and in groups 3 and 4 than in group 1 (all P < 0.001). However, it was comparable between groups 1 and 2 (P > 0.05). It correlated with the duration of T1DM and HbA1c, total cholesterol, triglyceride, and creatinine levels but not with age.

Conclusions: Patients with T1DM with DR showed higher serum chemerin levels than those with T1DM without DR or healthy individuals. Serum chemerin levels were higher in those with PDR than in those with NPDR. Thus, serum chemerin levels are a potential biomarker of the development and severity of DR in patients with T1DM. Nevertheless, future diagnostic accuracy studies are required to confirm these potential applications.
Brolucizumab (Beovu)
Authors: CADTH
Published: February 2023

CADTH recommends that Beovu be reimbursed by public drug plans for the treatment of diabetic macular edema (DME) if certain conditions are met.

Beovu should be covered to treat patients with DME provided that Beovu is covered for a similar patient population and in a similar way to other anti–vascular endothelial growth factor (VEGF) drugs currently reimbursed by public drug plans for the treatment of adult patients with DME.

Beovu should only be reimbursed if prescribed by an ophthalmologist with experience in managing DME and if its cost is not more than the least costly anti-VEGF drug covered by the public drug plans for the treatment of DME.
Dupilumab (Dupixent)
Authors: CADTH
Published: February 2023

CADTH recommends that Dupixent should be reimbursed by public drug plans for the treatment of patients aged 6 to younger than 12 years with severe asthma with a type 2/eosinophilic phenotype if certain conditions are met.

Dupixent should only be covered for patients with severe asthma aged 6 to younger than 12 years with a type 2 or eosinophilic phenotype if their asthma is not controlled despite using medium- or high-dose inhaled corticosteroids (ICSs) and at least 1 additional medication or high-dose ICS alone, and if they have had at least 1 severe asthma exacerbation in the past year.

Dupixent should only be reimbursed if prescribed by a pediatric respirologist or allergist, patients are managed by physicians with experience treating asthma in pediatric patients, and the price is reduced. Dupixent should not be used with other biologics.
Interannual polar vortex-ozone co-variability
Authors: Harzer Frederik , Garny Hella , Ploeger Felix , Bönisch Harald , Hoor Peter , Birner Thomas
Published: February 2023

Abstract. Stratospheric ozone is important for both stratospheric and surface climate. In the lower stratosphere during winter its variability is governed primarily by transport dynamics induced by wave-mean flow interactions. Here, we focus on interannual co-variations between the zonal mean ozone distribution and the strength of the polar vortex during northern hemispheric winter. Specifically, we study co-variability between the seasonal means of the ozone field from modern reanalyses and polar cap-averaged temperature at 100 hPa, which represents a robust and well-defined index for polar vortex strength. We consider variability in both pressure and isentropic coordinates. In the former case, we find that anomalously weak polar vortex years are associated with increased polar ozone amounts, showing two pronounced local maxima: one in the lower to mid-stratosphere and one just above the polar tropopause. In contrast, in isentropic coordinates, only the mid- to lower stratosphere shows increased ozone, while a small negative ozone anomaly appears in the lowermost stratosphere. These differences are related to contributions due to anomalous adiabatic vertical motion, which are implicit in potential temperature coordinates. In general, our analyses of the ozone budget in the extratropical middle stratosphere show that interannual polar ozone variability can be explained by a combination of anomalous diabatic downwelling and quasi-isentropic eddy mixing that are associated with consecutive, counteracting anomalous ozone tendencies on daily time scales. We find that approx. 71 % of the total variability of polar column ozone in the stratosphere is associated with year-by-year variations in polar vortex strength based on ERA5 reanalyses for the winter seasons 1980–2022. MLS observations for 2005–2020 show that around 86 % can be explained by polar vortex co-variability.