bluuebunny/crossref_metadata_2025 huggingface dataset:
Germline Testing in a Cohort of Patients at High Risk of Hereditary Cancer Predisposition Syndromes: First Two-Year Results from South Italy
Authors: Paduano Francesco , Colao Emma , Fabiani Fernanda , Rocca Valentina , Dinatolo Francesca , Dattola Adele , D’Antona Lucia , Amato Rosario , Trapasso Francesco , Baudi Francesco , Perrotti Nicola , Iuliano Rodolfo
Published: July 2022

Germline pathogenic variants (PVs) in oncogenes and tumour suppressor genes are responsible for 5 to 10% of all diagnosed cancers, which are commonly known as hereditary cancer predisposition syndromes (HCPS). A total of 104 individuals at high risk of HCPS were selected by genetic counselling for genetic testing in the past 2 years. Most of them were subjects having a personal and family history of breast cancer (BC) selected according to current established criteria. Genes analysis involved in HCPS was assessed by next-generation sequencing (NGS) using a custom cancer panel with high- and moderate-risk susceptibility genes. Germline PVs were identified in 17 of 104 individuals (16.3%) analysed, while variants of uncertain significance (VUS) were identified in 21/104 (20.2%) cases. Concerning the germline PVs distribution among the 13 BC individuals with positive findings, 8/13 (61.5%) were in the BRCA1/2 genes, whereas 5/13 (38.4%) were in other high- or moderate-risk genes including PALB2, TP53, ATM and CHEK2. NGS genetic testing showed that 6/13 (46.1%) of the PVs observed in BC patients were detected in triple-negative BC. Interestingly, the likelihood of carrying the PVs in the moderate-to-high-risk genes calculated by the cancer risk model BOADICEA was significantly higher in pathogenic variant carriers than in negative subjects. Collectively, this study shows that multigene panel testing can offer an effective diagnostic approach for patients at high risk of hereditary cancers.
The Complete Mitochondrial Genome of Ophioglossum vulgatum L. Is with Highly Repetitive Sequences: Intergenomic Fragment Transfer and Phylogenetic Analysis
Authors: Hao Jing , Liang Yingyi , Su Yingjuan , Wang Ting
Published: July 2022

Many plant mitochondrial (mt) genomes have been sequenced but few in ferns. Ophioglossum vulgatum represents a typical species of fern genus Ophioglossum with medicinal and scientific value. However, its mt genome structure remains to be characterized. This study assembled and annotated the complete O. vulgatum mt genome and presented its structural characters and repeat sequences firstly. Its mt and chloroplast (cp) transfer sequences were explored, and the phylogenetic significance of both mt and cp genomes was also evaluated at the family level. Our results showed that the complete mt genome of O. vulgatum is a single circular genome of 369,673 bp in length, containing 5000 dispersed repetitive sequences. Phylogenetic trees reconstructed from cp and mt genomes displayed similar topologies, but also showed subtle differences at certain nodes. There exist 4818 bp common gene fragments between cp and mt genomes, of which more than 70% are located in tRNA intergenic regions (in mt). In conclusion, we assembled the complete mt genome of O. vulgatum, identified its remarkable structural characters, and provided new insights on ferns. The complementary results derived from mt and cp phylogeny highlighted that some higher taxonomic-level phylogenetic relationships among ferns remain to be resolved.
The Epitranscriptome in miRNAs: Crosstalk, Detection, and Function in Cancer
Authors: del Valle-Morales Daniel , Le Patricia , Saviana Michela , Romano Giulia , Nigita Giovanni , Nana-Sinkam Patrick , Acunzo Mario
Published: July 2022

The epitranscriptome encompasses all post-transcriptional modifications that occur on RNAs. These modifications can alter the function and regulation of their RNA targets, which, if dysregulated, result in various diseases and cancers. As with other RNAs, miRNAs are highly modified by epitranscriptomic modifications such as m6A methylation, 2′-O-methylation, m5C methylation, m7G methylation, polyuridine, and A-to-I editing. miRNAs are a class of small non-coding RNAs that regulates gene expression at the post-transcriptional level. miRNAs have gathered high clinical interest due to their role in disease, development, and cancer progression. Epitranscriptomic modifications alter the targeting, regulation, and biogenesis of miRNAs, increasing the complexity of miRNA regulation. In addition, emerging studies have revealed crosstalk between these modifications. In this review, we will summarize the epitranscriptomic modifications—focusing on those relevant to miRNAs—examine the recent crosstalk between these modifications, and give a perspective on how this crosstalk expands the complexity of miRNA biology.
A Field-Based Evaluation of the Reliability of Empirical Formulae for Quantifying the Longitudinal Dispersion Coefficient in Small Channels
Authors: Nogare Marianni A. , Bauer Bernard O.
Published: July 2022

The majority of formulae for predicting in-channel mixing by longitudinal dispersion are based on empirical evidence from medium to large rivers, whereas small creeks and streams are under-represented despite their hydrological and ecological importance. In this study, twenty-six formulae for predicting the longitudinal dispersion coefficient (Kx) were evaluated for their applicability to small channels using field measurements and hydraulic modeling. Predicted values for Kx, following guidelines recommended in the original publications for the formulae, were compared to measured dispersion coefficients obtained from sodium-chloride plumes injected into two small channels (a concrete-lined, trapezoidal channel and a small, natural stream) based on fitting the Hayami solution to the one-dimensional advection-dispersion equation (ADE) to each plume. The predicted Kx coefficients from the formulae were also utilized to create model-simulated plumes, which were compared to those measured well downstream of the point of injection. The findings demonstrate that the predictive accuracy of the twenty-six formulae was extremely variable; none were able to predict the dispersion process in the small channels with better than ± 50% accuracy. These results show that “universal” formulae are plagued with a large degree of uncertainty and should be used with caution when applied to small channels, although more robust predictions are possible with some formulae if site-specific data are available for calibration.
Relationship between Edinburg Postnatal Depression Scale (EPDS) Scores in the Early Postpartum Period and Related Stress Coping Characteristics
Authors: Magawa Shoichi , Yanase Sachiko , Miyazaki Tsutako , Igura Kazumasa , Maki Shintaro , Nii Shota , Nii Masafumi , Tanaka Hiroaki , Kondo Eiji , Ikeda Tomoaki , Kageyama Takayuki
Published: July 2022

Despite postpartum depression being a common mental health problem, there is no screening method for it. The only risk assessment used is the Edinburgh Postnatal Depression Scale (EPDS). We investigated the relationship between Brief Scale for Coping Profile (BSCP) subscales performed during pregnancy and EPDS scores. We recruited 353 women with normal pregnancies (160 primiparas, and 193 multiparas) and performed BSCP at 26 weeks of gestation. The EPDS was first performed within one week after delivery (T1), and then after one month (T2). Spearman’s correlation coefficients were calculated for the BSCP and EPDS for the whole and primi/multipara groups. Multiple regression analysis was performed with the EPDS T2 scores as the dependent variable. The EPDS scores were higher in the primipara group compared to the multipara (p < 0.001), and the EPDS T1 scores were higher than the overall T2 score (p < 0.001). In the multiple regression analysis, EPDS T1 and the “seeking help for solution” subscale were selected as significant explanatory variables when analyzed in the whole group; EPDS T1 and “active solution” for the primiparas; and EPDS T1, “changing mood”, and “seeking help for solution” for the multiparas. The BSCP can be used as a screening tool for postpartum depression during pregnancy.
The Incident Feedback Committee (IFC): A Useful Tool to Investigate Errors in Clinical Research
Authors: David-Tchouda Sandra , Foote Alison , Bosson Jean-Luc
Published: July 2022

In clinical practice, an objective of safety management is to identify preventable causes of adverse events to avoid the incidents from recurring. Likewise, in the field of clinical research adequate methods to investigate incidents that impair the quality of a clinical trial are needed. Understanding the causes of errors and undesirable incidents can help guarantee participant safety, improve the practices of research coordinators, investigators, and clinical research assistants and help to minimize research costs. Here, we present the main features of our Incident Feedback Committees (IFC) in clinical research, with outcomes over 5 years. Methods: The IFC has adapted the ALARM and ORION post-event methods with investigations focused on ‘the incidents’ occurring during research studies. It sought the root causes contributing to these incidents and proposed corrective actions. Results: Since our IFC was set up in 2015 it has examined 52 incidents from nine studies. The most frequent causes mainly concerned the working environment (54%). Most incidents had two or more causes. Some corrective actions were planned for ongoing or future studies. Conclusion: IFCs provide a useful and much-appreciated method of analysing incidents in the performance of clinical research. A multicentre study is needed to evaluate the effect of IFCs on the quality of an establishment’s clinical research, at the individual level (patient safety) and also at the system level (changes in the organization of tasks).
Analysis of Retinal Blood Vessel Diameters in Pregnant Women Practicing Yoga: A Feasibility Study
Authors: Dinevski Dejan , Lučovnik Miha , Žebeljan Ivan , Guzelj Domen , Dinevski Izidora , Saloň Adam , De Boever Patrick , Goswami Nandu
Published: July 2022

Studies have shown that practicing yoga during pregnancy beneficially affects maternal and neonatal outcomes. The objective of this study was to determine the effect of prenatal yoga on the microvascular circulatory system via non-invasive measurements of retinal blood vessels. We included 29 women who practiced prenatal yoga in the study. There were no statistically significant differences in arteriolar and venular diameters pre- vs. post-90 min yoga practice (150.5 ± 11.4 μm pre- vs. 151.2 ± 10.2 μm post-yoga; p = 0.53 for arteriolar and 221.8 ± 16.1 μm pre- vs. 223.2 ± 15.7 μm post-yoga; p = 0.51 for venular diameters). The current study demonstrated the feasibility of the setup. More extensive studies are needed to determine the potential microvascular effects of practicing yoga throughout pregnancy.
Integrated SRNA-Seq and RNA-Seq Analysis Reveals the Regulatory Roles of miRNAs in the Low-Temperature Responses of Canarium album
Authors: Lai Ruilian , Guan Qingxu , Shen Chaogui , Feng Xin , Zhang Yongyan , Chen Yiting , Cheng Chunzhen , Wu Rujian
Published: July 2022

Chinese olive (Canarium album), a characteristic fruit tree in tropical and subtropical areas, suffers greatly from low-temperature stress (LTS). The regulatory roles of microRNA (miRNA) in plant LTS responses have been confirmed in many plant species but not in C. album. In this study, a cold-tolerant cultivar ‘Rui’an 3′ (RA) and a susceptible cultivar ‘Qinglan 1’ (QL) treated at 25 °C (control, CK) and −3 °C (cold temperature treatment, CT) were subjected to small RNA (sRNA) and transcriptome sequencing for the exploration of the cold responses of C. album. Comparative sRNA sequencing analysis identified much fewer LTS-responsive, differentially expressed miRNAs (DEMs) in RA (4 DEMs) than in QL (23 DEMs). Cal-miR482-22 was found to be specifically induced by LTS in RA. Cal-miR397-3 was upregulated, while cal-miR398_2-3 and cal-undef-190 were downregulated after LTS only in QL. However, when compared with QL, a higher basic expression of cal-miR397-3, and lower expression of cal-miR398_2-3 and cal-undef-190 were found in RA, suggesting that they may contribute to the cold tolerance of RA. Comparative transcriptome analysis showed that the number of LTS-responsive differentially expressed genes (DEGs) identified in QL was larger than that in RA, and some DEGs were also predicted as the target genes of the identified DEMs, forming multiple differentially expressed miRNA–target gene pairs, such as cal-miR397-3_laccase 2, 4, 17, cal-miR482-22_suppressor of npr1-1, etc. Quantitative real time PCR results showed that the expression changes of DEGs and DEMs in different samples were generally consistent with the sequencing results. Our study indicated that the basic expression levels of some miRNAs (especially the cal-miR397-3, cal-miR398_2-3, and cal-miR482-22), and their target genes contribute greatly to the cold-tolerance characteristics of C. album. Our study is helpful for understanding the roles of miRNAs in the cold resistance and responses of C. album.
Review of Urban Flood Resilience: Insights from Scientometric and Systematic Analysis
Authors: Gao Meiyan , Wang Zongmin , Yang Haibo
Published: July 2022

In recent decades, climate change is exacerbating meteorological disasters around the world, causing more serious urban flood disaster losses. Many solutions in related research have been proposed to enhance urban adaptation to climate change, including urban flooding simulations, risk reduction and urban flood-resistance capacity. In this paper we provide a thorough review of urban flood-resilience using scientometric and systematic analysis. Using Cite Space and VOS viewer, we conducted a scientometric analysis to quantitively analyze related papers from the Web of Science Core Collection from 1999 to 2021 with urban flood resilience as the keyword. We systematically summarize the relationship of urban flood resilience, including co-citation analysis of keywords, authors, research institutions, countries, and research trends. The scientometric results show that four stages can be distinguished to indicate the evolution of different keywords in urban flood management from 1999, and urban flood resilience has become a research hotspot with a significant increase globally since 2015. The research methods and progress of urban flood resilience in these four related fields are systematically analyzed, including climate change, urban planning, urban system adaptation and urban flood-simulation models. Climate change has been of high interest in urban flood-resilience research. Urban planning and the adaptation of urban systems differ in terms of human involvement and local policies, while more dynamic factors need to be jointly described. Models are mostly evaluated with indicators, and comprehensive resilience studies based on traditional models are needed for multi-level and higher performance models. Consequently, more studies about urban flood resilience based on local policies and dynamics within global urban areas combined with fine simulation are needed in the future, improving the concept of resilience as applied to urban flood-risk-management and assessment.
The Role of Social Responsibility and Ethics in Employees’ Wellbeing
Authors: Bocean Claudiu George , Nicolescu Michael Marian , Cazacu Marian , Dumitriu Simona
Published: July 2022

Social responsibility (SR) is a concept or practice by which organizations take into account the interest of society by taking responsibility for the impact of their activities on all stakeholders. The SR of organizations implies ethical behavior concerning all stakeholders and a company’s commitment to the sustainable economic development of society. Organizational ethics is a set of written and unwritten codes of principles and values that govern decisions and actions within an organization. Ethics has a rather internal perspective, while social responsibility has a rather external perspective. This study examines the impact of social responsibility and organizational ethics on employees’ wellbeing. To perform the empirical analysis, we conducted a survey among 423 employees from Romanian organizations. Using the structural equation modeling, we analyzed the relationships between social responsibility, organizational ethics, and employees’ wellbeing, emphasizing the positive impact of ethical and responsible behavior of the organization on the employees’ wellbeing. The organization’s employees play a dual role: firstly, they are all internal stakeholders, and secondly, they are constituents of an external stakeholder essential for the organization—the community. The results show a significant positive influence of social responsibility and organizational ethics on employees’ wellbeing as a result of a responsible and ethical behavior in relation to the organizational stakeholders.
Gender Differences in Suicide and Homicide Rates in Mexico City during 2019
Authors: Nicolini Humberto , Sánchez-de la Cruz Juan Pablo , Castillo Avila Rosa Giannina , López-Narvaéz María Lilia , González-Castro Thelma Beatríz , Chávez-Manjarrez Sophia , Montes-de-Oca José Eduardo , Martínez Magaña Jaime , Tovilla-Zárate Carlos Alfonso , Genis Mendoza Alma Delia
Published: July 2022

Suicides and homicides are public health problems around the world. The rates of suicide and homicide have increased in the past years. The objectives of this study are to estimate the rates of suicide and homicide in Mexico City, and to determine the rates of suicide and homicide by sex in the different municipalities of Mexico City during 2019. Data analyzed were obtained from files of governmental organizations in Mexico City. From the general victims-in-research-folders, we choose “victims of crime” or “loss of life by suicide” that happened in 2019. Sex and municipality of residence were obtained. The rate of suicide was of 5.65 cases per 100,000 habitants. Stratified by gender and by municipalities, the highest rates observed were 6.8 suicides per 100,000 males and 29.6 suicides per 100,000 females. The sex ratio was 4.2:1 (males: females). Regarding homicides, the rates were 16.68 homicides per 100,000 females and 67.41 homicides per 100,000 males. The Venustiano Carranza Municipality showed the highest homicide rate in men with 131.72 homicides per 100,000 males. The homicide sex ratio was 7.8:1. The findings of the present study highlight that death by suicide is more common in men with 7.8 more times than in women. The municipalities with higher deaths by suicide have lower rates of homicides and the municipalities with higher deaths by suicide showed lower rates of suicide in men.
The Effects of Self-Perceived Parenting Attitudes on Visuo-Spatial Attention and Mental Rotation Abilities among Adolescents
Authors: Kim Sangyub , Baik Yeonji , Nam Kichun
Published: July 2022

The present study aimed to investigate the effect of adolescents’ perceived negative evaluation of parenting on their visuo-spatial attention and mental rotation abilities. The useful field of view (UFOV) and mental rotation tasks were used to measure visuo-spatial attention and mental rotation abilities among adolescents. The experimental groups were divided into the negatively evaluating group (MAge = 18.44, SD = 0.87, 20.7% girls) and positively evaluating group (MAge = 18.40, SD = 0.81, 23.3% girls) based on their scores on the self-perceived parenting attitude scales. The UFOV task showed lesser accuracy of the negatively evaluating group when compared to the positively evaluating one in target perception presented in 20° visual angle, indicating a deteriorated visuo-spatial attention ability in the negatively evaluating group. In the mental rotation task, the negatively evaluating group exhibited a small trade-off effect between response times and rotation angles, which implied an impatient strategy was employed to perform the task, whereas such a trade-off was not observed in the positively evaluating group. Thus, both experimental groups differed in terms of their visual attention and mental spatial abilities. This study suggests that the reduced visuo-spatial attention and mental rotation abilities may act as precursors for serious psychological symptoms caused by the negative self-evaluation of their parents’ parenting attitudes.
Contributing Factors of Presenteeism among Portuguese and Swiss Nurses: A Qualitative Study Using Focus Groups
Authors: Laranjeira Carlos , Pereira Filipa , Querido Ana , Bieri Marion , Verloo Henk
Published: July 2022

Evidence of nurse presenteeism has mainly focused on quantifying its prevalence and consequences on productivity, quality of care, and patient safety. Few data exist on nurses’ perceptions of their presenteeism and its related causes. We explored concepts of presenteeism and its contributing factors with frontline nurses and nurse managers in different healthcare settings in Portugal and Switzerland. Our qualitative study design involved 8 online focus groups involving 55 participants. The transcribed data was explored using thematic analysis. Three main reasons for presenteeism were identified: unfamiliar terminology; the paradoxical effect of `being present’ but absent; and presenteeism as a survival strategy. Six contributing factors were also recognized: (a) institutional disinterest toward employees; (b) paradigm shift: the tension between person-centered and task-centered care; (c) sudden changes in care practices due to the COVID-19 pandemic; (d) a lack of shared work perspectives with hierarchical superiors; (e) the financial burden of being absent from work; and (f) misfit of human responses. This study generates valuable, in-depth knowledge about the concepts and causes of presenteeism, and significant suggestions for the broader audience of nurse managers and leaders seeking to improve the quality of care.
Mapping Scientific Productivity Trends and Hotspots in Remdesivir Research Publications: A Bibliometric Study from 2016 to 2021
Authors: Ogunsakin Ropo E. , Ebenezer Oluwakemi , Jordaan Maryam A. , Shapi Michael , Ginindza Themba G.
Published: July 2022

In response to global efforts to control and exterminate infectious diseases, this study aims to provide insight into the productivity of remdesivir research and highlight future directions. To achieve this, there is a need to summarize and curate evidence from the literature. As a result, this study carried out comprehensive scientific research to detect trends in published articles related to remdesivir using a bibliometric analysis. Keywords associated with remdesivir were used to access pertinent published articles using the Scopus database. A total of 5321 research documents were retrieved, primarily as novel research articles (n = 2440; 46%). The number of publications increased exponentially from 2020 up to the present. The papers published by the top 12 institutions focusing on remdesivir accounted for 25.69% of the overall number of articles. The USA ranked as the most productive country, with 906 documents (37.1%), equivalent to one-third of the global publications in this field. The most productive institution was Icahn School of Medicine, Mount Sinai, in the USA (103 publications). The New England Journal of Medicine was the most cited, with an h-index of 13. The publication of research on remdesivir has gained momentum in the past year. The importance of remdesivir suggests that it needs continued research to help global health organizations detect areas requiring instant action to implement suitable measures. Furthermore, this study offers evolving hotspots and valuable insights into the scientific advances in this field and provides scaling-up analysis and evidence diffusion on remdesivir.
Nonlinear Effects of the Built Environment on Light Physical Activity among Older Adults: The Case of Lanzhou, China
Authors: Zang Peng , Qiu Hualong , Xian Fei , Yang Linchuan , Qiu Yanan , Guo Hongxu
Published: July 2022

The aging of the population is increasing the load on the healthcare system, and enhancing light physical activity among older adults can alleviate this problem. This study used medical examination data from 1773 older adults in Lanzhou city (China) and adopted the random forest model to investigate the effect of the built environment on the duration of light physical activity of older adults. The results showed that streetscape greenery has the most significant impact on older adults’ light physical activity; greenery can be assessed in a hierarchy of areas; population density and land-use mix only have a positive effect on older adults’ light physical activity up to a certain point but a negative effect beyond that point; and a greater distance to the park within 1 km is associated with a longer time spent on light physical activity. Therefore, we conclude that the built environment’s impact is only positive within a specific range. Changes in the intervention of environmental variables can be observed visually by calculating the relative importance of the nonlinearity of built environment elements with partial dependency plots. These results provide a reasonable reference indicator for age-friendly community planning.
Spanish Translation and Cultural Adaptation of the Canadian Assessment of Physical Literacy-2 (CAPL-2) Questionnaires
Authors: Pastor-Cisneros Raquel , Carlos-Vivas Jorge , Adsuar José Carmelo , Barrios-Fernández Sabina , Rojo-Ramos Jorge , Vega-Muñoz Alejandro , Contreras-Barraza Nicolás , Mendoza-Muñoz María
Published: July 2022

Background: This study aimed to translate and culturally adapt the questionnaires belonging to the Canadian Assessment of Physical Literacy-2 (CAPL-2) into Spanish and to explore the reliability for its use in children and adolescents aged from 8 to 12 years. Methods: The CAPL-2 questionnaires were translated using the translation–back-translation methodology into Spanish and adapted to the Spanish context. The test–retest reliability and internal consistency of the CAPL-2 questionnaires of this Spanish version were analysed in 57 schoolchildren from a school in the region of Extremadura (Spain). Results: High internal consistency (α = 0.730 to 0.970) and test–retest reliabilities ranging from moderate to almost perfect in the knowledge and understanding domain (ICC = 0.486 to 0.888); from substantial to almost perfect in the motivation and confidence domain (ICC = 0.720 to 0.981); and almost perfect in the daily activity domain (ICC = 0.975) were found. The test–retest correlation was significantly weak to strong (r = 0.266 to 0.815) in both the motivation and confidence and knowledge and understanding domains, except for the third predilection item and the muscular endurance question. Significant test–retest differences were observed in the first intrinsic motivation item (p = 0.027) and the knowledge and understanding domain total score (p = 0.014). Conclusion: The Spanish version of the CAPL-2 questionnaires, translated and adapted to the context, are reliable measurement tools, serving to complete the full adaptation of the CAPL-2 test battery for use in children aged 8 to 12 years.
Intimate Partner Violence (IPV) in Military and Veteran Populations: A Systematic Review of Population-Based Surveys and Population Screening Studies
Authors: Cowlishaw Sean , Freijah Isabella , Kartal Dzenana , Sbisa Alyssa , Mulligan Ashlee , Notarianni MaryAnn , Couineau Anne-Laure , Forbes David , O’Donnell Meaghan , Phelps Andrea , Iverson Katherine M. , Heber Alexandra , O’Dwyer Carol , Smith Patrick , Hosseiny Fardous
Published: July 2022

Intimate partner violence (IPV) may be a major concern in military and veteran populations, and the aims of this systematic review were to (1) provide best available estimates of overall prevalence based on studies that are most representative of relevant populations, and (2) contextualise these via examination of IPV types, impacts, and context. An electronic search of PsycINFO, CINHAL, PubMed, and the Cochrane Library databases identified studies utilising population-based designs or population screening strategies to estimate prevalence of IPV perpetration or victimisation reported by active duty (AD) military personnel or veterans. Random effects meta-analyses were used for quantitative analyses and were supplemented by narrative syntheses of heterogeneous data. Thirty-one studies involving 172,790 participants were included in meta-analyses. These indicated around 13% of all AD personnel and veterans reported any recent IPV perpetration, and around 21% reported any recent victimisation. There were higher rates of IPV perpetration in studies of veterans and health service settings, but no discernible differences were found according to gender, era of service, or country of origin. Psychological IPV was the most common form identified, while there were few studies of IPV impacts, or coercive and controlling behaviours. The findings demonstrate that IPV perpetration and victimisation occur commonly among AD personnel and veterans and highlight a strong need for responses across military and veteran-specific settings. However, there are gaps in understanding of impacts and context for IPV, including coercive and controlling behaviours, which are priority considerations for future research and policy.
Derivation of Soil Criteria of Cadmium for Safe Rice Production Applying Soil–Plant Transfer Model and Species Sensitivity Distribution
Authors: Li Xuzhi , Du Junyang , Sun Li , Zhang Ya , Feng Yanhong , Zheng Liping , Wang Guoqing , Huang Xinghua
Published: July 2022

Widespread soil contamination is hazardous to agricultural products, posing harmful effects on human health through the food chain. In China, Cadmium (Cd) is the primary contaminant in soils and easily accumulates in rice, the main food for the Chinese population. Therefore, it is essential to derive soil criteria to safeguard rice products by assessing Cd intake risk through the soil–grain–human pathway. Based on a 2-year field investigation, a total of 328 soil–rice grain paired samples were collected in China, covering a wide variation in soil Cd concentrations and physicochemical properties. Two probabilistic methods used to derive soil criteria are soil–plant transfer models (SPT), with predictive intervals, and species sensitivity distribution (SSD), composed of soil type-specific bioconcentration factor (BCF, Cd concentration ratio in rice grain to soil). The soil criteria were back-calculated from the Chinese food quality standard. The results suggested that field data with a proper Cd concentration gradient could increase the model accuracy in the soil–plant transfer system. The derived soil criteria based on soil pH were 0.06–0.11, 0.33–0.59, and 1.51–2.82 mg kg−1 for protecting 95%, 50% and 5% of the rice safety, respectively. The soil criteria with soil pH further validated the soil as being safe for rice grains.
The Need to Implement Health Technology Assessment in Polish Hospitals—A Survey of 50 Hospital Managers
Authors: Farkowski Michał M. , Lach Krzysztof , Pietrzyk Malwina , Baryla-Zapala Ewelina , Gałązka-Sobotka Małgorzata , Kowalska-Bobko Iwona , Kępka Cezary , Hryniewiecki Tomasz
Published: July 2022

Hospital-based health technology assessment (HB-HTA) is a scientific approach to inform decisions on investments in health technologies across multiple medical specialties at a hospital level. HB-HTA is not currently practiced in Poland. This study aimed to assess the need for HTA in Polish hospitals, including perceived benefits and challenges of adoption of HB-HTA in Poland, expected demand for training in HB-HTA, and perception of incentives to foster HB-HTA adoption. Study data were gathered using the computer-assisted telephone interview (CATI) technique. Between June and August 2021, 50 interviews were conducted: 52% of respondents had over 10 years of experience, and 40% comprised the highest degree reference hospitals. A high or moderate need for HB-HTA was reported by 86% of managers. The ability to indicate valuable and affordable medical technologies was the main reported benefit of HB-HTA (90%). The main obstacle to the adoption of HB-HTA was the shortage of competent staff (84%). The most important incentives to adopt HB-HTA were free training and premium financing from the National Health Fund. There is a clear need for HB-HTA in Polish hospitals despite some important obstacles.
Low Cardiorespiratory Fitness, Muscular Fitness, and Flexibility Are Associated with Body Fat Distribution and Obesity Risk Using Bioelectrical Impedance in Taiwanese Adults
Authors: Chiang Hsiu-Hsi , Lee Po-Fu , Chen Yun-Tsung , Lin Chi-Fang , Xu Shu , Lin Yi-Tien , Lin Yu-Ting , Su Yan-Jhu , Shia Ben-Chang , ChangChien Wen-Sheng , Ho Chien-Chang
Published: July 2022

In terms of public health, obesity and overweight have become major concerns worldwide. Nevertheless, regarding body composition, it is important to have a more precise understanding of the fat-to-muscle ratio. Hence, this study aimed to adopt bioelectrical impedance measurements to test body fat percentage (BF%) and to determine the associations between health-related physical fitness and both body fat (BF) distribution and BF obesity risk in Taiwanese adults. We conducted a cross-sectional study and reviewed data derived from Taiwan’s Scientific Physical Fitness Survey. From the database, responses from 17,970 participants aged 23–64 years were collected in this study. Each participant completed a series of health-related physical fitness measurements, including cardiorespiratory fitness (3 min of a progressive knee-up and step (3MPKS) test), muscular fitness (hand-grip strength), and flexibility (sit-and-reach test). The BF% of each participant was assessed using the bioelectrical impedance analysis method. BF% was negatively associated with low performance on the 3MPKS (β = 11.314, p < 0.0001 for men; β = 12.308, p < 0.0001 for women), hand-grip strength (β = 2.071, p < 0.0001 for men; β = 0.859, p < 0.0001 for women), and sit-and-reach (β = 0.337, p = 0.008 for women) tests but was positively associated with sit-and-reach (β = −0.394, p = 0.004 for men). A risk of BF obesity for low performance of 3MPKS (odds ratio (OR) = 26.554, p < 0.0001 for men; OR = 25.808, p < 0.0001 for women), hand-grip strength (OR = 1.682, p < 0.0001 for men; OR = 1.234, p < 0.0001 for women), and sit-and-reach (OR = 1.142, p = 0.007 for women) tests was observed. These results suggest that low levels of cardiorespiratory fitness, muscular fitness, and flexibility are associated with an increased risk of BF obesity.
Linking Self-Control, Hope, Positivity Ratio, Anxiety and Handwashing Habits during the Coronavirus Outbreak
Authors: Bukchin-Peles Shira , Ronen Tammie
Published: July 2022

The novel COVID-19 is an infectious disease caused by the coronavirus. In the early stages of the pandemic, Israel struggled to contain its local outbreak through various measures that have virtually halted daily life and placed tens of thousands of people into quarantine. This study explored the role played by self-control and hope for obtaining two desired outcomes: (1) maintaining one’s positivity ratio (having more positive than negative affect—an indicator of wellbeing) and (2) increasing one’s contagion-preventing behavior (in this study—handwashing habits). Path analysis was conducted using survey data collected from 537 Israeli adults. Our findings suggest that self-control’s association with the positivity ratio is mediated through hope and anxiety levels. Self-control positively correlates with hope levels and negatively correlates with anxiety levels. Higher hope levels correlate with a higher positivity ratio, while lower anxiety levels correlate with a higher positivity ratio. The relationship between self-control and handwashing habits was mediated by hope, anxiety, and existing handwashing habits. This study brings research a step forward in demonstrating the vital role of positive components in achieving desired psychological and behavioral outcomes during an anxiety-provoking epidemic outbreak. In addition to its theoretical innovation, the importance of this study lies in its practical value: We focus on variables that are influenced by policy, education, and communication.
Associations between Awareness of the Risk of Exposure to Pollutants Occurring at Fire Scenes and Health Beliefs among Metropolitan Firefighters in the Republic of Korea
Authors: Oh Hye Eun , Kim Soo Jin , Woo Hyekyung , Ham Seunghon
Published: July 2022

Firefighters are repeatedly exposed to various pollutants that occur at fire scenes. There are three levels of exposure: primary exposure to pollutants, secondary exposure to pollutants on personal protective equipment (PPE), and tertiary exposure to contaminated fire stations and fire engines due to pollutants on PPE. Therefore, it is important for firefighters to be aware of the risk of exposure to pollutants and to practice health behaviors such as appropriate PPE management. No clear association has been established in the existing literature between firefighters’ risk perception level and their health beliefs about the health impact of awareness of exposure to hazardous substances at fire scenes. This study aims to evaluate the relationship between awareness of the exposure risk to primary, secondary, and tertiary pollutants and health beliefs. It was designed as a cross-sectional study, in which a web-based survey was conducted from 13 May to 31 May 2021. The analysis was conducted in 1940 firefighters working in the Seoul metropolis who agreed to participate in the research. Participants who perceived susceptibility were likely to be aware of the primary (adjusted odds ratio (AOR) = 2.10, 95% confidence interval (CI) 1.16–3.80), secondary (AOR = 2.77, 95% CI 1.77–4.32), and tertiary (AOR = 2.73, 95% CI 1.85–4.03) exposure risks. Participants who perceived barriers were unlikely to be aware of the risk of exposure to primary (AOR = 0.67, 95% CI 0.49–0.91), secondary (AOR = 0.77, 95% CI 0.61–0.96), and tertiary (AOR = 0.75, 95% CI 0.62–0.91) pollutants. Educational intervention is recommended to improve perceived susceptibility and awareness of the risk of exposure to pollutants and reduce perceived barriers. Consequently, educational intervention is expected to positively impact firefighters’ management of appropriate PPE. We confirmed an association between occupational exposure risk and firefighters’ health beliefs. In the health belief model (HBM), health beliefs that affect health behavior also affect awareness of the exposure risk level. Therefore, an intervention for health beliefs can also be used to raise job-related exposure risk awareness. Regular training on the health impacts of fire scenes is necessary for both newcomers and incumbents to enable firefighters to better recognize the risks of each occupational exposure level. Additionally, laws and regulations are necessary for the removal of harmful substances that contaminate PPE, such as self-contained breathing apparatus (SCBA), during exposure to a fire scene. Our research can be used as a basis for improving fire policies and education programs in the future.
Cutaneous Manifestations of COVID-19 in the Lower Limbs: A Narrative Review
Authors: Palomo-Toucedo Inmaculada C. , López-Sánchez Manuel Jesús , Reina-Bueno María , Coheña-Jiménez Manuel
Published: July 2022

In 2020, the World Health Organization declared the COVID-19 pandemic. This infectious pathology can be associated with different manifestations in different body systems, among which are dermatological lesions. The purpose of this work is to determine the most frequent dermatological signs, in the lower limbs, produced by SARS-CoV-2. To carry this out, a bibliographic search was performed in the following databases: PubMed, SciELO, ScienceDirect, Cochrane Database of Systematic Reviews, and the Google Scholar literature. The inclusion criteria were articles that included confirmed subjects or those with a clinical suspicion of COVID-19, written in the Spanish or English languages, and the results presented clinical manifestations in the lower extremities. Initially, 128 scientific documents were identified and, after reading the title and abstract, 18 articles were selected. The most frequent skin lesions on the lower limbs are acral lesions such as pernio erythema or ischemic lesions, maculopapular rash, petechiae, and erythematous plaques.
Pre-Existing Medical Conditions: A Systematic Literature Review of a Silent Contributor to Adult Drowning
Authors: Peden Amy E. , Taylor Danielle H. , Franklin Richard C.
Published: July 2022

Medical conditions can increase drowning risk. No prior study has systematically reviewed the published evidence globally regarding medical conditions and drowning risk for adults. MEDLINE (Ovid), PubMed, EMBASE, Scopus, PsycINFO (ProQuest) and SPORTDiscus databases were searched for original research published between 1 January 2005 and 31 October 2021 that reported adult (≥15 years) fatal or non-fatal drowning of all intents and pre-existing medical conditions. Conditions were grouped into the relevant International Classifications of Diseases (ICD) codes. Eighty-three studies were included (85.5% high-income countries; 38.6% East Asia and Pacific region; 75.9% evidence level III-3). Diseases of the nervous system (n = 32 studies; 38.6%), mental and behavioural conditions (n = 31; 37.3%) and diseases of the circulatory system (n = 25; 30.1%) were the most common categories of conditions. Epilepsy was found to increase the relative risk of drowning by 3.8 to 82 times, with suggested preventive approaches regarding supervised bathing or showering. Drowning is a common suicide method for those with schizophrenia, psychotic disorders and dementia. Review findings indicate people with pre-existing medical conditions drown, yet relatively few studies have documented the risk. There is a need for further population-level research to more accurately quantify drowning risk for pre-existing medical conditions in adults, as well as implementing and evaluating population-level attributable risk and prevention strategies.
Examine Race/Ethnicity Disparities in Perception, Intention, and Screening of Dementia in a Community Setting: Scoping Review
Authors: Lee SangA , Kim Deogwoon , Lee Haeok
Published: July 2022

Background: Delayed detection and diagnosis of Alzheimer’s Disease and related dementia (ADRD) can lead to suboptimal care and socioeconomic burdens on individuals, families, and communities. Our objective is to investigate dementia screening behavior focusing on minority older populations and assess whether there are ethnic differences in ADRD screening behavior. Methods: The scoping review method was utilized to examine ADRD screening behavior and contributing factors for missed and delayed screening/diagnosis focusing on race/ethnicity. Results: 2288 papers were identified, of which 21 met the inclusion criteria. We identified six dimensions of ADRD screening behavior: Noticing Symptoms, Recognizing a problem, Accepting Screen, Intending Screen, Action, and Integrating with time. Final findings were organized into study race/ethnicity, theoretical background, the methods of quantitative and qualitative studies, description and measures of ADRD screening behavior, and racial/ethnic differences in ADRD screening behavior. Conclusions: A trend in ethnic disparities in screening for ADRD was observed. Our findings point to the fact that there is a scarcity of studies focusing on describing ethnic-specific ADRD screening behavior as well as a lack of those examining the impact of ethnicity on ADRD screening behavior, especially studies where Asian Americans are almost invisible.
Is the Prevalence of Low Physical Activity among Teachers Associated with Depression, Anxiety, and Stress?
Authors: Biernat Elżbieta , Piątkowska Monika , Rozpara Michał
Published: July 2022

The aim of this study was to analyze the levels of stress, depression, and anxiety among Polish secondary school teachers and their association with selected psychosocial, sociodemographic, and lifestyle factors. A cross-sectional study was conducted among 116 Polish teachers in 2019, using the International Physical Activity Questionnaire—Short Form (IPAQ-SF), the Depression and Anxiety Stress Scale (DASS-21), and author questionnaire including psychosocial factors specific to the respondents’ work environment. The prevalence of moderately to extremely severe levels of depression, anxiety, and symptoms of stress in teachers was 18.1%, 22.4%, and 51.7%, respectively. Among respondents with moderate or high physical activity level (PAL), normal or mild levels of depression (OR = 3.62; CI [1.31–10.03]), anxiety (OR = 2.61; CI [1.01–6.73]), and stress (OR = 2.79; CI [1.16–6.69]) were more common. The level of individual symptoms of mental disorders was higher than indicated by previous Polish reports. Given that teachers’ low PAL is significantly related to their moderately to extremely severe levels of stress, depression, and anxiety, we suggest running leisure-time physical activity (LTPA) enhancement programs and supporting the leadership of school management and the higher-education system in this regard.
Price Promotions of E-Liquid Products Sold in Online Stores
Authors: Ma Shaoying , Jiang Shuning , Ling Meng , Chen Jian , Shang Ce
Published: July 2022

Background: Retailer price promotions are an important marketing strategy to attract consumers. However, there is scarce evidence on how retail price promotions are being implemented by e-cigarette online stores, particularly for e-liquid products that are not often found in brick-and-mortar stores and sold in lower prices compared to other types of e-cigarettes. Objectives: We collect data on e-liquid price-promotion activities from online stores using web scraping. From February to May 2021, we scraped the price promotion data of over 14,000 e-liquid products, from five popular online vape shops that sell nationwide in the US. We present descriptive analyses of price promotion on those products, assess price promotion practices in online stores, and discuss components of the final purchase price paid by online customers. Findings: Of the 14,000 e-liquid products and over, 13,326 (92.36%) were on sale, and each online store on average offered discounts from 9.20% to 47.53% for these products. The distribution of the after-discount price was largely similar across the five stores, and there is evidence that each store had adopted different price-promotion strategies. Conclusion: Despite low prices, price promotions are common for e-liquid products, which may undermine the effect of e-cigarette pricing policies such as excise tax that are designed to raise e-cigarette prices.
A Systematic Review of Internet-Based Interventions for the Prevention and Self-Management of Cardiovascular Diseases among People of African Descent
Authors: Usman Jesse Enebi , Childs Charmaine , Rogerson David , Klonizakis Markos
Published: July 2022

Cardiovascular disease (CVD) risk factors, morbidity, and mortality among people of African descent (PAD) appear to be higher than in the general population. While it has been found that lifestyle changes can prevent around 90% of CVDs, implementing an effective lifestyle programme is expensive and time-consuming. It has been demonstrated that Internet-based interventions (IbIs) can effectively and inexpensively encourage lifestyle modifications to prevent and manage chronic diseases. Although a number of studies have examined the effectiveness of IbIs in the general population, no comprehensive study of the usefulness and acceptability of IbIs among PAD has been conducted. This is the knowledge gap that this study aimed to address. We searched MEDLINE, EMBASE, CINAHL, and Web of Science to identify eligible studies published from inception to February 2022. Thirteen articles met our criteria for inclusion. Our textual narrative synthesis produced inconsistent results; nonetheless, high acceptability of IbIs and a considerable improvement in clinical and behavioural outcomes associated with CVDs were reported in several trials. The findings of this review are constrained by clinical, methodological and statistical variability among the studies. To have a good grasp on the effect of IbIs on behaviour change in PAD at risk of CVDs, large-scale longitudinal studies with long-term follow-up are required.