bluuebunny/crossref_metadata_2025 huggingface dataset:
Louis Jullien
Authors: McLeod Jillian
Published: February 2021

Well known for his extravagant appearance, Louis Jullien (1812-1860), a prominent conductor in England, programmed concerts that were entertaining and accessible to the public. During the nineteenth century, conductors began to take responsibility for the artistic and musical direction of their concerts. Jullien’s concerts included dance, choral, and classical music to appeal to a variety of tastes. His theatricality on the podium and use of a baton captivated his audiences, while his distinctive conducting personality contributed to the visual appeal of the concert experience. Audience members and musical reviewers alike were attracted to the spectacular display at Jullien’s concerts.

Through the examination of articles in the Musical World, the most important London-based music periodical published in Jullien’s time, and Romantic orchestral scholarship, this research investigates Louis Jullien’s role as a conducting figure. While Adam Carse has described the biographical accounts of Jullien’s life and Holly Mathieson has examined the artistic representations of Jullien and has interpreted his conducting as militaristic and magical, scholars have not yet examined the sublime in the reception of Jullien’s performance. Jullien’s virtuosic self presentation and performance behaviour inspired responses that drew upon the language of the sublime and influenced how he was received as a visionary figure. His status as a visionary was further developed by his innovations as a conductor.
A STUDY ON POTENTIAL DRUG-DRUG INTERACTIONS AMONG PATIENTS ADMITTED UNDER DEPARTMENT OF MEDICINE IN A TERTIARY CARE HOSPITAL IN INDIA
Authors: Bandyopadhyay Sanjib , Mitra Kaushik , Bhaumik Dipankar , Das Saibal
Published: February 2021

Objective: This study was conducted to evaluate the potential drug-drug interactions (pDDIs) among patients admitted in a tertiary care hospital in India.

Methods: This was anobservational and cross sectional study for 3 months. All the patients admitted in the general ward under Department of Medicine. Pre-structured proforma and patient’s charts were be used for data collection on the 2nd day of admission. For drug interactions, online ‘Medscape Drug Interaction Checker’ was used.

Results: A total of 61 charts were screened. A total of 304 drugs with 57 different types were admitted to these patients (including all dosage forms and routes). The total number of pDDIs were 217, of them 69 were minor, 130 were significant and 18 were serious (including repetitions in different patients). There were 13 unique serious pDDIs.

Conclusion: The incidence of pDDIs in our study was high. Controlled study to evaluate whether good clinical management of DDIs can reduce drug-related morbidity or mortality is needed.

Keywords:Potential drug-drug interactions (pDDIs), adverse drug reactions (ADRs), poly-medication, hospitalization, pharmacokinetic and pharmacodynamics interactions.
PATHOPHYSIOLOGY, TYPES, ITS MEDIATORS & TREATMENT STRATEGIES OF ALZHEIMER’S DISEASE: A SHORT REVIEW
Authors: Singh Puneet , Sharma Yogesh , Sharma Ashutosh
Published: February 2021

Cognition in an extensive sense means information dispensation. It denotes a relatively high level of processing of definite information including thinking, memory, perception, incentive, skilled arrangements and language. Learning is the most attribute attributes of the man and also of higher animals. Learning is definite as the skill to alter behavior on the basis of understanding. We know that some reminiscences last for only a few seconds, whereas others last for hours, days, months or year. Dementia is generally defined as the loss of logical abilities (medically called cognitive dysfunction) of sufficient capacity to interfere with social or occupational functioning.  People with DLB have some of the symptoms common in Alzheimer’s, but are more likely than people with Alzheimer’s to have initial or early symptoms such as sleep disturbances, well-formed visual hallucinations, and muscle rigidity or other parkinsonian movement features. The signature lesions in AD are neuritic plaques and neurofibrillary tangles (NFTs) to be found in the cortical areas and medial temporal lobe structures of the brain.

Keywords: Alzheimer, Neurofibrillary tangles, Neuritic plaques, Dementia, Temporal lobe
Antimicrobial Activity of Ethanolic and Methanolic Extracts of Urtica dioica, Mentha longifolia, and Bacteriocin Produced by Lactobacillus casei Against Antibiotic-Resistant Bacteria
Authors:   Department of microbiology, faculty of medicine, Shahid Sadoughi University of medical sciences, Yazd, Iran, Kiani Masoumeh , Pournajaf Abazar ,   Infectious Diseases and Tropical Medicine Research Center, Health Research Center, Babol University of Medical Sciences, Babol, Iran 3- University of Surrey, Business school, Guildford, United Kingdom, Zareh Thelma ,   Department of Microbiology and Virology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran, Karami Mohsen ,   nfectious Diseases and Tropical Medicine Research Center, Health Research Center, Babol University of Medical Sciences, Babol, Iran, Taghizadeh Armaki Mojtaba ,   Infectious Diseases and Tropical Medicine Research Center, Health Research Center, Babol University of Medical Sciences, Babol, Iran, Gholami Mehrdad ,   Department of Microbiology and Virology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
Published: February 2021

Background: The increasing resistance of human microbial pathogens to the available antibacterial compounds is a significant threat, resulting in the search for new antibiotic resources such as plants and probiotics. Therefore, this study aimed to evaluate the antibacterial effect of ethanolic and methanolic extracts of Urtica dioica, Mentha longifolia, and bacteriocin purified from a probiotic bacteria using the standard disk diffusion method against some pathogenic strains. Materials and methods: Ethanolic/methanolic extract of U. dioica, M. longifolia, and bacteriocin from probiotic bacteria were prepared by the standard methods. The effect of different concentrations of the extracts on some antibiotic-resistant bacteria was evaluated using the standard disk diffusion method by measuring the diameter of the growth inhibition zone. Results: The disk diffusion test showed that the bacteriocin Lactobacillus casei had more growth inhibitory effects on the tested bacterial strains than the methanolic and ethanolic extracts of U. dioica and M. longifolia. Bacteriocin extract of L. casei exhibited significant antibacterial activity at the concentrations of 12 and 18 mg/mL (P≤0.05) against antibiotic-resistant bacteria, while a 12 mm zone of inhibition was observed in the concentration of 1.5 mg/mL against Salmonella enterica serovar Typhimurium (S. Typhimurium). Conclusion: According to the agar well diffusion method results, the bacteriocin producing L. casei has an extensive range of antibacterial spectrum against resistant bacteria. It can be used as an alternative to antimicrobia agents for the treatment of infections caused by resistant bacteria. It is suggested that in future research, the cytotoxicity of the extracts be evaluated in vitro/in vivo studies.
nticoagulative Effect of Two Species of Brown Algae; Sargassum Angustifolium and Cystoseira Indica
Authors:   Department of Hematology, School of Para Medicine, Bushehr University of Medical Sciences, Bushehr, Iran., Obeidi Narges , Mousavi Mohammad Javad ,   Department of Hematology, School of Para Medicine, Bushehr University of Medical Sciences, Bushehr, Iran., Hosseinpouri Arghavan ,   epartment of Cellular and Molecular Sciences, Faculty of Sciences, Persian Gulf University, Bushehr, Iran., Malekhayati Hamideh ,   Student Research Committee, Bushehr University of Medical Sciences, Bushehr, Iran., Ehsandoost Elham ,   Department of Food Science & Technology, Shiraz University, Shiraz, Iran.
Published: February 2021

Background: Fucoidans are a group of sulfated fucose-rich polysaccharides that are isolated from brown marine algae and echinoderms, and recently have been found in seagrasses. Fucoidans, as well as their derivatives, have several beneficial biological effects and therapeutic potentials. In the present study, we aimed to evaluate the anticoagulative effects of two species of brown algae, namely Sargassum angustifolium (S. angustifolium) and Cystoseira indica (C. indica). Methods: Fucoidan C and fucoidan S were extracted by an ethanol/water solvent system from S. angustifolium and C. indicia, respectively. The anticoagulative effects of fucoidan C and fucoidan S were tested on 10 normal serum samples by evaluating the rate of thrombin time (PT) and prothrombin time (PTT). Results: Both fucoidan C and fucoidan S significantly increased PTT. However, no significant difference was observed in PT. Fucoidan C had a greater effect on PTT prolongation compared with fucoidan S. Conclusion: Both fucoidans extracted from S. angustifolium and C. indicia can be used as anticoagulants in biotechnology and human disorders.
HER2 Testing in Invasive Breast Cancer: A Comparison Between Immunohistochemistry and Fluorescence In Situ Hybridization Assays
Authors:   Genetics Division, Biology Department, Faculty of Sciences, University of Isfahan, Isfahan, Iran, Moradi Chaleshtori Maryam , Hojati Zohreh ,   Genetics Division, Department of Biology, Faculty of Sciences, University of Isfahan, Isfahan, Iran, Jazaeri Ali ,   Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran, Teimori Hossein ,   Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
Published: February 2021

Background: HER2 status testing in breast cancer is crucial for the detection of eligible patients for trastuzumab therapy. In this study, the relative copy number of HER2 gene, in patients with breast cancer, was determined by fluorescence in situ hybridization (FISH) and the results were compared with those of immunohistochemistry (IHC) to obtain the concordance rate between these two methods. Material and Methods: HER2 status of 31 invasive breast cancer samples was compared using IHC and FISH techniques. The ratio of HER2/CEP17 was used to determine the amplification of the HER2 gene. If the ratio of HER2/CEP17 is greater than 2.2, HER2 gene amplification has occurred in the cancer cells. Then, a comparative analysis is performed to estimate the concordance rate between FISH and IHC results. Results: The gene amplification of HER2 was observed in 26% of cases by FISH. The IHC and FISH results showed 100%, 36.36%, and 85.71% concordance rates for cases with IHC scores of 3+, 2+, and 0/+1, respectively. The overall concordance between the two methods was 80%. Based on statistical analysis, HER2 status showed a considerable correlation with tumor grade (P= 0.02). No correlation was observed between HER2 gene status and the size and type of tumor, characteristics of lymph node, and patients’ age. Conclusion: The data suggested that IHC results are reliable for HER2 status testing in cases with IHC scores 0/+1 and 3+. However, in patients with an IHC score of +2, it is necessary to perform a complimentary test to evaluate HER2 status to avoid haphazard treatment with trastuzumab in negative cases and identifying positive cases for suitable treatment.
Inhibitors of Angiotensin-converting Enzyme or Blockers of Angiotensin-2 Receptor in COVID-19 Patients with Comorbid Cardiovascular or Pulmonary Diseases
Authors:   Research School of Biology, The Australian National University, Canberra, Australia, Rahimi Farid , Talebi Bezmin Abadi Amin ,   Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
Published: February 2021

N/A
The Association between C194T and G399A Polymorphism of XRCC1 Gene and Susceptibility to Gastric Cancer in Population from Western Iran
Authors:   Department of Biology, Faculty of Sciences, Hakim Sabzevari University, Sabzevar, Iran.,, Vatandoost Jafar , Sanaie Maryam ,   Medical Biology Research Center, Health Technology Institute Kermanshah University of Medical Science, Kermanshah, Iran., Yari Kheirollah ,   Zagros Bioidea Co., Razi University Incubator, Kermanshah, Iran,
Published: February 2021

Background: Gastric cancer is one of the most common malignancies in the world. It may result from a defect in the genes involved in DNA repair. One of the essential genes in the repair pathway is the XRCC1 gene that its polymorphisms in the human population play a role in gastric cancer susceptibility. The main purpose of this study was to investigate the association of 194C/T and 399G/A polymorphisms of the XRCC1 gene with gastric cancer in an Iranian population. Materials and methods: A total of 66 patients with gastric cancer and 67 control individuals were enrolled in our study. Following DNA extraction from blood samples, polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. Results: The allele frequencies of C/T of XRCC1-194C/T in the control and patients groups were 83.17% and 71.29%, respectively. Moreover, The allele frequencies of G/A of XRCC1-399G/A in control and patient groups were 66.34% and 62.38%, respectively. Our results indicated a significant positive association between the distribution T/C alleles and the risk of gastric cancer (χ2: 5.37 and P=0.02), but no significant association was found in the distribution G/A alleles (χ2: 0.47 and P=0.48). Conclusion: Altogether, these findings indicate a positive association between the distribution of 194T/C alleles of XRCC1 and the risk of gastric cancer and the presence of the C allele may increase the risk of gastric cancer.
The Right Space: The Impact of Meaningful Dialogue in Informing Culturally Safe Care in the Emergency Department in a Rural Northern Community
Authors: Carter Victoria , Healy Theresa , Nelson Fanny
Published: February 2021

This project focused on emergency department (ED) care provided in a rural northern Canadian community. It studied how supported and meaningful dialogue between health authority providers and physicians whose work is associated with the ED, and providers who work with Indigenous people outside the health authority, helped inform culturally safe care in the ED. Guided by Indigenous and non-Indigenous advisory committee members, this participatory action study created a space for dialogue that allowed the perspectives of two worlds and multiple disciplines to emerge and develop solutions. The findings demonstrated what culturally safe and unsafe care in the ED look like, identified current culturally safe practices, and described factors that challenge culturally safe care. This project, although small, was unique because of the degree of collaboration in health care improvement between those inside and outside the health authority. Supportive dialogue that is mutually negotiated to include attention to culturally safe practice may be the starting place for the creation of the right space, the ethical space, which is so crucial in moving forward. From this foundation, there are six priority suggestions on how to enhance culturally safe care within an ED setting. These recommendations, built from dialogue within a locally generated ethical space, may extend beyond the local context and may be crucial for supporting cultural safety more broadly in the health care system. The findings presented here were the result of a research project undertaken as part of a master’s degree and do not reflect the views of any other body.
It’s a Journey Not a Check Box: Indigenous Cultural Safety From Training to Transformation
Authors: Wylie Lloy , McConkey Stephanie , Corrado Ann Marie
Published: February 2021

Indigenous Peoples in Canada continue to experience racism and discrimination when accessing health care. Competencies of health care staff urgently need to be improved through cultural safety education and training programs to inform culturally appropriate and safe care practice among care providers serving Indigenous individuals and families. This paper explores current educational strategies, the perspectives of Indigenous and non-Indigenous care providers on training approaches, and recommendations for improving training. Qualitative semi-structured interviews were conducted with 31 participants to explore the current provision of culturally appropriate and safe care. Interviews were voice recorded and transcribed verbatim, and a thematic analysis was completed. The three key themes related to training that emerged from data analysis were (a) addressing the knowledge gaps, (b) challenges of current training approaches, and (c) recommendations for improvements in training. Each key theme had three subthemes that were further explored. Cultural safety training is a long and iterative process that has the potential to change care providers’ behaviours and attitudes. Various challenges to existing education and training included issues with implementation, limited follow up with health care staff to support practice changes, and/or limited commitment from senior leadership to change organizational policies and practices. As such, there is a clear need for systemic change within health care institutions to support staff participating in cultural safety training and to put that training into practice to create a culturally safe space for Indigenous individuals seeking health care.
Gum yan asing Kaangas giidaay han hll guudang gas ga. I Will Never Again Feel That I Am Less Than: Indigenous Health Care Providers’ Perspectives on Ending Racism in Health Care
Authors: Kétéskwēw Dion Stout Madeleine , Wieman Cornelia (Nel) , Bourque Bearskin Lisa , Palmer Becky C. , Brown Lauren , Brown Monica , Marsden Namaste
Published: February 2021

Racism toward Indigenous Peoples continues to permeate throughout the health care system, a reality the authors know all too well in their shared and yet unique personal and professional experiences. Although acknowledging and speaking up against racial injustice is daunting, and is often met with disregard or inaction, the authors contend that this is a necessary undertaking to redress the ongoing harms of colonialism. Correspondingly, those who do not speak up must not have their voices silenced. Instead, the perspectives that Indigenous Peoples have regarding their own experiences of racism must be heeded seriously and produce real and tangible solutions. In narrating their own encounters of confronting and challenging racism, the authors juxtapose activism and resistance with the preservation of Indigenous Knowledge as a catalyst for propelling the necessary changes forward within health care to end racism. To be truly impactful, all efforts taken to address racism must occur alongside advancing equity of care and human rights for and by Indigenous Peoples at individual, community, and systemic levels. Changes are not needed after more evidence. The time to act is now.
Project George: An Indigenous Land-Based Approach to Resilience for Youth
Authors: Gaudet Janice Cindy
Published: February 2021

The research shared in this article seeks an understanding of Indigenous resilience within the context of a culturally responsive land-based initiative, Project George, led by the Moose Cree First Nation, also known as the Omushkego people. The initiative centres core Cree values, community engagement, and land-based skills to ensure the well-being of youth. Their Homeland is located in the waterways and on the western shores of the Hudson and James Bay Lowlands in Ontario, Canada. The methodology involved researcher participation and engagement as part of a 4-month field presence; informal conversations and visiting; as well as formal semistructured interviews with community members over 4 years from 2012 to 2015. The research explores the benefits and challenges of a land-based program by highlighting the experiences and voices of community and program participants who directly engaged with Project George. The findings show that land-based learning initiatives inspired and driven by Indigenous people foster a regenerative approach to wellness based on relation to land, culture, and identity. A return to land-based learning responds to the ongoing colonial complexities affecting the health and wellness of Indigenous youth in Canada and draws strength from the people’s resilient practices.
Developer/Adapter Method: A Community-Based Approach to Improve Health in Indigenous Communities
Authors: McElhaney Janet E. , Helmer Joyce , Briggs Marion CE , Andrew Melissa K , McGilton Katherine S , Moeke-Pickering Taima , Jackson Pulver Lisa , McKenna Elder Betty
Published: February 2021

The purpose of this paper is to provide a narrative of our experience with community-driven change using our “Developer/Adapter” research method in Northern Ontario, Canada, so it can be explored in other First Nations contexts. The goal of our currently funded research is to identify community solutions and knowledge and implement community-developed interventions to better support older Indigenous persons, especially those in rural and remote communities, to “age in place” and remain independent in the community through timely access to relevant care. Our Developer/Adapter research method was developed in response to the community-identified need for self-determination to overcome the limitations of traditional Western approaches and effectively plan and execute change in Indigenous communities. Our approach commits to supporting a self- determining voice for Indigenous people and working collaboratively to develop wholistic care interventions. We believe this approach can generate compelling data for policy and practice change in both Canada and Australia.
Hā Ora: Reflecting on a Kaupapa Māori Community-Engaged Co-design Approach to Lung Cancer Research
Authors: Kidd Jacquie , Cassim Shemana , Rolleston Anna , Keenan Rawiri , Lawrenson Ross , Sheridan Nicolette , Warbrick Isaac , Ngaheu Janette , Hokowhitu Brenda
Published: February 2021

Co-designed research is gaining prominence within the health care space. Community engagement is a key premise of co-design and is also particularly vital when carrying out kaupapa Māori research. Kaupapa Māori describes a “by Māori, for Māori” approach to research in Aotearoa/New Zealand. This article discusses the research process of Hā Ora: a co-design project underpinned by a kaupapa Māori approach. The objective was to explore the barriers to early presentation and diagnosis of lung cancer, barriers identified by Māori. The team worked with four rural Māori communities, with whom we aimed to co-design local interventions that would promote earlier diagnosis of lung cancer. This article highlights and unpacks the complexities of carrying out community- engaged co-design with Māori who live in rural communities. In particular, we draw attention to the importance of flexibility and adaptability in the research process. We highlight issues pertaining to timelines and budgets, and also the intricacies of involving co-governance and advisory groups. Overall, through this article, we argue that health researchers need to prioritise working with and for participants, rather than on them, especially when working with Māori communities.
Adapting Evidence-Based Tobacco Addiction Treatment for Inuit Living in Ontario: A Qualitative Study of Collaboration and Co-creation to Move From Pan-Indigenous to Inuit-Specific Programming
Authors: Barker Megan , Uuttuvak Anita , Lund Christine , Dragonetti Rosa , Selby Peter
Published: February 2021

Settler introduction of tobacco to Inuit Nunangat (homeland of Inuit in Canada) has led to high tobacco use prevalence among Inuit. Inuit are moving from traditional territories to the province of Ontario to access resources, including health services. Indigenous-specific tobacco cessation approaches in Ontario lack cultural relevance among Inuit, as they often reflect First Nations and Métis worldviews. To improve effectiveness of tobacco cessation services for Inuit living in Ontario, materials reflective of Inuit culture and worldviews were developed through a community-based participatory approach. The Centre for Addiction and Mental Health collaborated with Tungasuvvingat Inuit and members of an Engagement Circle who work with Inuit or identify as Inuk (n = 25) to initiate a knowledge translation project aimed at co-creating a toolkit of Inuit-specific cessation resources. Development was guided by Two-Eyed Seeing, whereby Inuit and Western worldviews come together to support a strengths-based approach. The toolkit was evaluated through a pilot session and focus group with Inuit living in Ottawa who use tobacco (n = 13) and an online survey administered with a group of helpers who work with Inuit (n = 11). Analysis of qualitative data from the focus group and online survey highlighted five themes: choice, cultural relevance and safety, capacity-building, access, and impact. Focus group participants reported they learned quitting was possible and identified new strategies to quit through the session. Our findings emphasize the importance of engagement and co-creation with Indigenous Peoples to ensure cultural relevance and appropriateness of healthcare interventions.
Indigenous End-of-Life Doula Course: Bringing the Culture Home
Authors: Gaspard Gina , Gadsby Carrie , Mallmes Jennifer
Published: February 2021

Many Indigenous people who live on their traditional territory die in hospital when their preference is to enter the spirit world from their home. Indigenous people in Canada describe experiencing many barriers that prevent them from making this final choice in life. The First Nations Health Authority in British Columbia (BC), Canada, in collaboration with Douglas College, offered end-of- life doula training classes to Indigenous people in BC in 2019. The goal was to build on the strengths of community members already supporting people and their families during their final journey into the spirit world. There were 86 participants (72% identified as Indigenous) from the five health regions in BC, representing 47 Indigenous communities. Participants were overwhelmingly satisfied with the five-day course and planned to take their new learnings back to their community. It was noted, however, that this course would benefit from adaptations, including a greater emphasis on traditional Indigenous practices, facilitation tips, and strategies to support people through loss and bereavement. Furthermore, the term “end-of-life doula” is sometimes associated with a for-profit business, which is counterintuitive to traditional Indigenous practices, highlighting the necessity for a name change. Further evaluation over the next year is necessary to confirm that the course makes a positive difference in the final journey for Indigenous people.
Indigenous Women Voicing Experiences of HIV Stigma and Criminalization Through Art
Authors: Mawdsley Amy , Ranville Flo , Gurney Lulu , Borden Barb , Pooyak Sherri , Shannon Kate , Krüsi Andrea
Published: February 2021

Indigenous women living with HIV are disproportionately affected by the criminalization of HIV nondisclosure. The purpose of this paper is to better understand how the criminalization of HIV nondisclosure shapes the lived experiences of HIV-related stigma, disclosure, and health service among cis and transgender Indigenous women living with HIV (IWLWH). This study was developed based on a community roundtable on HIV criminalization with engagement of legal experts, HIV service organizations, and IWLWH on the unceded traditional territory of the Coast Salish Peoples, including the ter̓ritories of the xwməθkwəy̓ əm (Musqueam), Sḵwx̱ wú7mesh (Squamish), and Səlílwətaɬ (Tsleil-Waututh) Nations (Vancouver, British Columbia, Canada) in 2016 to 2018. Drawing on community-based participatory photovoice methodology, Indigenous Peer Researchers played a central role throughout this project, including planning, facilitation of photo-voice workshops, and analysis. This analysis includes 17 IWLWH. Through a peer-engaged analysis process, the photovoice images and narratives illustrated how the criminalization of HIV nondisclosure is intertwined with colonial violence to shape experiences of social isolation and exclusion, disclosure, access to safe health care, responsibility, fear, and resilience. The legal requirements of HIV nondisclosure are unattainable for many IWLWH who are not able to safely disclose their HIV status, negotiate condom use, and maintain a low viral load. In line with the Truth and Reconciliation Commission of Canada and National Inquiry into Missing and Murdered Indigenous Women and Girls, the justice system must be reoriented from punishment and oppression to healing and wellbeing for all Indigenous women living with HIV. Simultaneously, we call for culturally safe services that protect privacy and recognize strengths of IWLWH.
ENVIRONMENTAL EDUCATION AND AWARENESS TO PROTECT EGYPTIAN TORTOISE (TESTUDO KLEINMANNI) BY LOCAL COMMUNITY PARTICIPATION
Authors: Buijlayyil Murad , Kiraz Aşkın
Published: February 2021

This research has examined the effectiveness of education and environmental awareness of the local population in protecting Egyptian tortoises. The study aimed to obtain information about the relationship between the level of education, monthly income and its relationship to tortoise protection and the prevention of smuggling and illegal trade. The results were obtained through the preparation of a questionnaire that included 40 people from the local population. They were surveyed using the SPSS26 program. According to the results obtained by the research, significant differences were found in the environmental attitudes of the local population who did not have a chance to have a good education and their monthly income was very low. It could be said that the people who got a good opportunity for education and their economic situation is stable, this has a positive impact on their environmental behaviour.

Keywords: environmental education, environmental awareness, Egyptian tortoise
METAPHOR ANALYSIS OF THE PERCEPTIONS OF "GLOBAL WARMING" AS A CONCEPT
Authors: Üretici Pelin
Published: February 2021

The environmental problem, defined as "global warming" in recent years, has developed as a result of human activities. This problem affects humanity with its economic, social and cultural dimensions as well as many other living species. Policies​ are being developed at national and international levels to cope with this problem and various opinions and practices are put forward. However, studies show that individuals have misconceptions about this issue. For this purpose, this study aims to understand the perceptions of 87 participants, 65 women and 22 men living in the TRNC, about global warming through a "metaphor analysis". The study was conducted using a qualitative phenomenology design. The data obtained were evaluated by content analysis method. Semi-structured forms were distributed for data collection. The first part of the form is based on demographic information, and the second part is to determine the perceptions of the participants about global warming. The analyzed metaphors were gathered under 13 different conceptual categories. Since this study does not consist of an equal number of male and female participants, gender differences should not be taken into account in the findings.

Keywords: Global warming, environmental management, metaphor analysis, environmental education
Interpretation of Family Members’ Involvement in Religious Groups
Authors: Abidin Kurniati
Published: February 2021

Family reactions and assessments of all family members towards family members belonging to specific religious groups still occur. This interpretation can trigger disharmony in the family and is an interesting social phenomenon to research. This research uses a qualitative research method. This research assumes that empirical realities occur in a socio-cultural context that is interrelated with one another. This research aims to describe family reactions, family social relationships, and family assessments on their family members’ involvement in specific religious groups. The informants were selected using a purposive sampling technique by taking three people from each religious group (Jamaah Tabligh, Wahdah Islamiyah, and Lembaga Dakwah Islam Indonesia known as LDII). Data were collected using in-depth interviews, observation, and documentation. The data analysis used in this research is descriptive qualitative. The results showed that family social relations on family members’ involvement in certain religious groups tended to get the same reaction based on their interpretation. Contravention interpretation from dominant family on family members belonging to specific religious groups still occurs compared with accommodative relationships. Meanwhile, family assessments on their family members’ involvement in certain religious groups are generally negative.
EXAMINING THE RELIABILITY AND VALIDITY OF RESEARCH INSTRUMENTS USING PARTIAL LEAST SQUARES STRUCTURAL EQUATION MODELING (PLS-SEM)
Authors: Chan Sane Hwui , Lay Yoon Fah
Published: February 2021

Understanding teacher’s behavioural intention in teaching science becomes a foundation to improve teacher education programme. Prior to the evaluation of the interrelation between teacher self-efficacy beliefs, teaching motivation, attitudes towards teaching science, and behavioural intention in teaching science, this research examines the reliability and validity of instruments used to measure the constructs. ‘Science Teaching Efficacy Belief Instrument-Form B’ (STEBI-B) was used to measure pre-service science teachers’ self-efficacy beliefs. ‘Work Tasks Motivation Scale for Teachers’ (WTMST) was used to measure teaching motivation. ‘Dimensions of Attitude towards Science’ (DAS) was used to measure attitudes towards teaching science whereas the ‘Behavioural Intention Scale’ was used to measure behavioural intention in teaching science among pre-service science teachers. Partial Least Square-Structural Equation Modelling approach was used to evaluate the reliability and validity of the instruments. Research findings concluded all instruments are valid and reliable to be used in future research.
Key words: self-efficacy beliefs, teaching motivation, attitudes towards teaching science, behavioural intention, partial least square-structural equation modeling.
PAST, PRESENT AND FUTURE OF JOURNAL OF BALTIC SCIENCE EDUCATION
Authors: Usak Muhammet
Published: February 2021

Science Education is a multidisciplinary field of study with roots about three centuries ago. Researches in this field were published for the first time in a scientific journal with School Science and Mathematics, which started in 1901. The number of scientific journals in Science Education has increased in parallel with the increase in the number of related research. The published literature is sometimes about trending topics. In some other cases, they offer novelty and new paradigms. Last 50 years of Science Education are shaped by various topics. Hence, these different issues are being published in scientific journals. At the end of the 70s, studies on constructivism, meaningful learning, misconception, conceptual learning (Driver, & Easley, 1978; Driver, 1983; Driver, & Oldham, 1986; von Glasersfeld, 1984; Ausubel, Novak, & Hanesian, 1978; Novak, 1979 & 1990, Novak, & Gowin, 1984; Novak, & Musonda, 1991) began to come forward. Conferences are being held especially on misconception. Many articles have been published and continue to be published on the topic. Starting with the second half of 80s, studies on PCK, which were first described by Shulman, began to surface in science education journals in the field of teacher training (Shulman, 1986; Usak, 2009, Usak, Ozden, & Eilks, 2011; Usak, Ozden, & Saglam, 2011).
PRACTICALITY AND EFFECTIVENESS OF THE IBMR TEACHING MODEL TO IMPROVE PHYSICS PROBLEM SOLVING SKILLS
Authors: Siswanto Joko , Susantini Endang , Jatmiko Budi
Published: February 2021

The design of a teaching model must qualify to be applicable or practical and effective, therefore the research aimed to analyze the practicality and effectiveness of the IBMR (Investigation-Based Multiple Representation) teaching model in improving physics problems solving skills of bachelor programs’ students. The research was conducted by applying the one-group pre-test and post-test pre-experimental design to 186 students of study program of physics education, mathematics education, and mechanical engineering. The practicality of the model is assessed using an observation sheet and the effectiveness is determined based on pre-test and post-test physics problem solving skills. The collected data were analyzed using the calculation of average scores of the feasibility of each phase of the IBMR, t-test, and n-gain. The results show that each phase of the IBMR teaching model can be implemented by a lecturer with good and reliable categories, and relevant student activities, so that the IBMR teaching model is practicality qualified. It is also effective shown by: there are increasing score of physics problem solving skills at  = 5%, average n-gain with moderate categorized and not different or consistent for each pair of groups, and good-categorized students’ responses on each component of teaching. Keywords: IBMR teaching model, model practicality, model effectiveness, physics problem solving skills, bachelor programs’ students.
EDUCATIONAL SHORT VIDEOS TO UTILIZE IN THE BIOCHEMISTRY LABORATORY: OPINIONS OF UNIVERSITY STUDENTS
Authors: Uyulgan Melis Arzu , Akkuzu Nalan
Published: February 2021

This research aimed to reveal the opinions of the university students who conducted original educational videos context for the experiments in the Biochemistry laboratory course. Participants were fourth year students (N=40) of the Mathematics and Science Education Department, in Chemistry Education Program. A case study was used and carried out during the Spring term of 2014 at the Faculty of Education of Dokuz Eylul University in Izmir, Turkey. The students designed and took participation in educational short videos. Besides, each group students prepared poster presentations of their video at the end of the 14-week implementation process. To collect data, semi-structured interviews were used. The interview results of the research showed that learning was more meaningful and valid through this laboratory course because the students attended the course with interest and favor and motivated positively. Eventually, the educational short videos can be a powerful convincing learning tool for students.
Keywords: active learning, educational short video, biochemistry laboratory, multimedia learning, science education.
PENGEMBANGAN PERANGKAT PEMBELAJARAN CIRC (COOPERATIVE INTEGRATED READING AND COMPOSITION) DALAM MENINGKATKAN PEMAHAMAN MATEMATIS PADA MATERI PERBANDINGAN SISWA SMP
Authors: Mulyadin Edi , Sowanto Sowanto , Dusalan Dusalan
Published: February 2021

Penelitian ini bertujuan untuk: (1) menghasilkan perangkat pembelajaran dengan model pembelajaran CIRC guna meningkatkan pemahaman siswa yang layak digunakan dalam proses pembelajaran, dan (2) mengetahui kualitas dan respon siswa terhadap perangkat pembelajaran yang telah dikembangkan dan digunakan dalam proses pembelajaran. Penelitian ini merupakan penelitian pengembangan (Research and Development) dengan model Ploomp. Subjek uji coba lapangan meliputi 30 siswa kelas VIII-7 di SMP Negeri 1 Kota Bima. Instrument yang digunakan berupa lembar validasi untuk validator (3 orang guru matematika di SMP Negeri 1 Kota Bima), lembar angket respon siswa, serta lembar observasi berupa angket soal analisis bagi siswa. Data kualitas produk yang diperoleh dari validator dianalisis dengan menggunakan analisis deskriptif, yaitu mengolah skor rata-rata aspek kualitas yang diperoleh dari nilai kuantitatif menjadi nilai kualitatif menggunakan kriteria kategori penilaian ideal. Hasil penilaian terhadap produk berupa draf  RPP, LKS dan Model Pembelajaran siswa menggunakan analisis data berupa pengolahan secara kuantitatif dan kualitatif. Penilaian dilakukan dengan mencari nilai rata-rata dari semua aspek penilaian prototipe oleh validator adalah 4,8 dengan kriteria kualitatif sangat valid. Sedangkan penilaian dari 30 siswa memiliki rata-rata nilai sebesar 33,93% dengan kriteria kualitatif cukup dengan presentase keidealan sebesar 50,88%. Data ini menunjukkan bahwa produk draf RPP, LKS dan Modul Pembelajaran Siswa yang dikembangkan dengan model pembelajaran CIRC dapat diaplikasikan di SMP Negeri 1 Kota Bima.
Anticoagulant Activity of Dayak Onion Bulb (Eleutherine bulbosa) Extract on Human Blood Samples
Authors: Handayati Anik , Arifin Syamsul , Astuti Monica Putji
Published: February 2021

Cardiovascular disease can occur due to disruption of the hemostatic system by forming blood clots in blood vessels, or commonly known as deep vein thrombosis. The curative action that has been carried out in the form of heparin anticoagulant administration had many side effects such as bleeding, hematuria, thrombocytopenia, and hypersensitivity; therefore, alternative anticoagulant ingredients such as onion bulbs have emerged. Dayak onion bulb (Eleutherine bulbosa) is known to contain eleutherinol compound, which has anticoagulant activity. This study aims to determine the potential anticoagulant activity of Dayak onion bulbs extract (Eleutherine bulbosa) on human blood samples. This anticoagulant activity test was carried out by observing the length of time for blood clotting in the extract treatment group with several concentrations (0, 10, 12.5, 16, 25, and 50%) by Clotting Time (Lee-White) method. The results showed a significant delay in blood coagulation time in the group treated with Dayak onion bulbs extract as increasing the concentration. About 50% Dayak onion onion bulb extract was showed a twofold increase in blood coagulation time thanthat of no extract administration. So that, Dayak bulb onion has the opportunity to be an alternative natural anticoagulant.

Keywords: anticoagulants; Dayak onion bulbs (Eleutherine bulbosa); clotting time
Toluene Dioxygenase-Catalyzed cis-Dihydroxylation of Quinolines: A Molecular Docking Study and Chemoenzymatic Synthesis of Quinoline Arene Oxides
Authors: Boyd Derek R. , Sharma Narain D. , Loke Pui L. , Carroll Jonathan G. , Stevenson Paul J. , Hoering Patrick , Allen Christopher C. R.
Published: February 2021

Molecular docking studies of quinoline and 2-chloroquinoline substrates at the active site of toluene dioxygenase (TDO), were conducted using Autodock Vina, to identify novel edge-to-face interactions and to rationalize the observed stereoselective cis-dihydroxylation of carbocyclic rings and formation of isolable cis-dihydrodiol metabolites. These in silico docking results of quinoline and pyridine substrates, with TDO, also provided support for the postulated cis-dihydroxylation of electron-deficient pyridyl rings, to give transient cis-dihydrodiol intermediates and the derived hydroxyquinolines. 2-Chloroquinoline cis-dihydrodiol metabolites were used as precursors in the chemoenzymatic synthesis of enantiopure arene oxide and arene dioxide derivatives of quinoline, in the context of its possible mammalian metabolism and carcinogenicity.
Mechanobiological Principles Influence the Immune Response in Regeneration: Implications for Bone Healing
Authors: Knecht Raphael S. , Bucher Christian H. , Van Linthout Sophie , Tschöpe Carsten , Schmidt-Bleek Katharina , Duda Georg N.
Published: February 2021

A misdirected or imbalanced local immune composition is often one of the reasons for unsuccessful regeneration resulting in scarring or fibrosis. Successful healing requires a balanced initiation and a timely down-regulation of the inflammation for the re-establishment of a biologically and mechanically homeostasis. While biomaterial-based approaches to control local immune responses are emerging as potential new treatment options, the extent to which biophysical material properties themselves play a role in modulating a local immune niche response has so far been considered only occasionally. The communication loop between extracellular matrix, non-hematopoietic cells, and immune cells seems to be specifically sensitive to mechanical cues and appears to play a role in the initiation and promotion of a local inflammatory setting. In this review, we focus on the crosstalk between ECM and its mechanical triggers and how they impact immune cells and non-hematopoietic cells and their crosstalk during tissue regeneration. We realized that especially mechanosensitive receptors such as TRPV4 and PIEZO1 and the mechanosensitive transcription factor YAP/TAZ are essential to regeneration in various organ settings. This indicates novel opportunities for therapeutic approaches to improve tissue regeneration, based on the immune-mechanical principles found in bone but also lung, heart, and skin.
Implication of Surface Properties, Bacterial Motility, and Hydrodynamic Conditions on Bacterial Surface Sensing and Their Initial Adhesion
Authors: Zheng Sherry , Bawazir Marwa , Dhall Atul , Kim Hye-Eun , He Le , Heo Joseph , Hwang Geelsu
Published: February 2021

Biofilms are structured microbial communities attached to surfaces, which play a significant role in the persistence of biofoulings in both medical and industrial settings. Bacteria in biofilms are mostly embedded in a complex matrix comprised of extracellular polymeric substances that provide mechanical stability and protection against environmental adversities. Once the biofilm is matured, it becomes extremely difficult to kill bacteria or mechanically remove biofilms from solid surfaces. Therefore, interrupting the bacterial surface sensing mechanism and subsequent initial binding process of bacteria to surfaces is essential to effectively prevent biofilm-associated problems. Noting that the process of bacterial adhesion is influenced by many factors, including material surface properties, this review summarizes recent works dedicated to understanding the influences of surface charge, surface wettability, roughness, topography, stiffness, and combination of properties on bacterial adhesion. This review also highlights other factors that are often neglected in bacterial adhesion studies such as bacterial motility and the effect of hydrodynamic flow. Lastly, the present review features recent innovations in nanotechnology-based antifouling systems to engineer new concepts of antibiofilm surfaces.
Having Our “Omic” Cake and Eating It Too?: Evaluating User Response to Using Blockchain Technology for Private and Secure Health Data Management and Sharing
Authors: Lemieux Victoria L. , Hofman Darra , Hamouda Hoda , Batista Danielle , Kaur Ravneet , Pan Wen , Costanzo Ian , Regier Dean , Pollard Samantha , Weymann Deirdre , Fraser Rob
Published: February 2021

This paper reports on end users' perspectives on the use of a blockchain solution for private and secure individual “omics” health data management and sharing. This solution is one output of a multidisciplinary project investigating the social, data, and technical issues surrounding application of blockchain technology in the context of personalized healthcare research. The project studies potential ethical, legal, social, and cognitive constraints of self-sovereign healthcare data management and sharing, and whether such constraints can be addressed through careful design of a blockchain solution.