bluuebunny/crossref_metadata_2025 huggingface dataset:
Recombinant tissue plasminogen activator (rTPA) in young adult patient with acute ischemic stroke: a case report
Authors: Tugasworo Dodik , Kurnianto Aditya , Retnaningsih Retnaningsih , Andhitara Yovita , Ardhini Rahmi , Dyaksani Runy , Budiman Jethro
Published: June 2021

Background: Stroke is one of the highest causes of morbidity and mortality in the world. The incidence rate of ischemic stroke is about 80% of all stroke incidents. The use of recombinant tissue plasminogen activator (rtPA) is recommended under 4.5 hours of stroke onset. Stroke in young adults are reported as being uncommon, compromising 10% -15% of all stroke patients. Many studies were reported the most common risk factor in young adults were obesity and dyslipidemia. This case report will discuss a 33-year-old men with ischemic stroke with obesity and dyslipidemia treated at dr. Kariadi Hospital Semarang.Case presentation: A 33-year old obese man with left-sided hemiparesis and central facial nerve palsy with an onset of 1 hour. On laboratory examination, it was obtained total cholesterol 179mg/dL, LDL level 123mg/dL, and HDL level 39mg/dL. The protocol code stroke was performed in emergency room with alteplase (r-TPA) 0.6 mg/kgBW, after his head MSCT shows there was no sign of blood in the brain parenchym.Conclusion: The increased risk of ischemic stroke in young patients is due to dyslipidemia, hypertension, obesity, physical inactivity, and smoking. Treatment of the hyperacute phase of ischemic stroke with thrombolysis can reduce the outcome of stroke due to the disability.
Anticancer and antioxidant effects of red cabbage on three cancerous cell lines and comparison with a normal cell line (HFF-3)
Authors: Tajalli Faezeh , Saeedi Mansour , Vafaei Malekabadi Atena
Published: June 2021

Red cabbage or scientifically Brassica oleracea is a rich source of anthocyanins exhibiting enormous antioxidant properties creating a perspective of its applications in healthcare sector. The aim of this study was the evaluation of antioxidant properties of red cabbage extract by DPPH radical scavenging assay, and exploration of its anticancer activity on the growth and viability of the desired human cancer cells by in vitro assay to detect cytotoxic activity. The results showed enhanced effects with increasing concentration exhibiting highest value of IC90+ at the concentration of 2500 µg/ml when it is compared with IC50 value of red cabbage extract at a concentration of 750 µg/ml. The polyphenol compounds were found 39.55 mg GAE/100 g of red cabbage extract and red cabbage extract increases the death rate of cancer cells and the cytotoxicity effect was dose dependent. It can be concluded that red cabbage extract should be used at lower concentrations than 6.4 mg/ml in order to prevent the normal human cell damage. Thus, it can be considered as a healthy foodstuff due to numerous phenolic compounds and powerful antioxidant and anticancer activity when it is used in moderate amount.
Role of Organ Specific Cancer Stem Cells in Organ Specific Cancer Progression
Authors: Ali Muhammad , Ali Fatima , Wajid Nadia
Published: June 2021

Since the cancer stem cells (CSC) have been identified in 1997 by Bonnet and Dick, more than 100,000 papers have been published on the CSC. Huge research on cancer stem cells helped the scientists to rethink about the cancer therapeutics as classic way of chemotherapy is ineffective because chemotherapy failed to kill these cells, the only reason of cancer relapse. The cancer theory of stem cells is one of the most trending theory in stem cells and cancer biology focusing on the understanding of biology of cancer cells for an enhanced and improved therapeutic approaches should be applied to cure the cancer. This mini-review is a short overview on the role of organ specific cancer stem cells in the organ specific cancer progression.
Papulonecrotic tuberculid: a case report
Authors: Karna Ni Luh Putu Ratih Vibriyanti , Rusyati Luh Made Mas
Published: June 2021

Introduction: Papulonecrotic tuberculid (PNT) is a chronic, recurrent, and symmetric eruption of necrotising skin papules in crops involving the arms and legs, and healing with scar formation. PNT is an uncommon disorder, occurring in less than 5 % of cases of active TB. The pathophysiology of this disease has remained controversial.Case: A 31 years old Balinese woman, visited Outpatient Clinic Department of Dermatology and Venereology Sanglah Hospital Denpasar in 8th September 2003, she has complained of recurrent ulcer for 14 years ago. The clinical feature showed papules, multiple ulcer, and scars, symmetrically on her arms, legs and trunk. Mantoux skin test was strongly positive with 13 mm induration. Lymphohystiocytic vasculitis was found on cell pathology examination, there is no evidence of microbial growth in culture, Ziehl-Neelsen staining and PCR was negative. She was given anti-tuberculosis with a rapid improvement after therapy for 6 months with no significant adverse event.Conclusion: Treatment for six months using anti-tuberculosis drugs provides satisfactory results with clinical improvement in patients with PNT.
Flap modalities for reconstruction following excision of vascular malformation on lower lip: a review with a case report
Authors: Haryanti Jenny Indah , Tanuwijaya Lucretya Yeniwati , Khairiza Rizka , Mas'ud Ahmad Fawzy
Published: June 2021

Background:Capillary malformations (CMs) and Lymphatic malformation (LMs) are vascular malformations that share a common tendency to cause soft and hard tissue hyperthropy, expressed in the three dimensions of the space. Although middle third of the face is the most commonly involved area, with a predominance of upper lip, the lower lip sometimes involved in some cases too. Vascular malformations of the lip often require reconstructive surgery with meticulous attention to both aesthetic and functional purposes. The lip reconstructive rule of thirds suggests that lower lip defects involving 1/3-2/3 total lip width require closure with lip switch or local advancement flap techniques (Karapandzic, Abbe, or Estlander).Case Description: 36 years old woman with bluish tumor lesion on lower lip since childhood, came to our clinic with history of Â small lesion enlarging slowly, bluish in color, elastic in palpation, no bruit in auscultation. She had underwent surgery to reduce the size of lesion twice while childhood and in adult. Then she felt the lesion became bigger and fulfilling the right edge extended to two third of the lower lip. She felt a little bit itchy, and a difficulty in eating. The surgeon performed a wide excision continued using lip reconstruction Karapandzic flap. The final result of the reconstruction is satisfactory for the patient, and no recurrence nor complication existed.Discussion:Vascular malformation which underwent correcting surgery should consider certain guidelines regarding anatomic consideration and therefore appropriate reconstruction according guideline methods, such as close primarily, Karapandzic, Estlander, Abbe, Bernard-Burrow, distant free flap, will provide good anatomical and physiological result in attected lip. The surgeon choose to perform Karapandzic method for this patient because Karapandzic is probably the better choice because itâ€™s better at maintaining oral competence. Larger lip defects over 50% of the lip can be reconstructed by Karapandzic flap.Â Conclusion: Karapandzic flaps is probably proper alternative due to reducing the larger lower lip defect (more than two-thirds of lip) which give a satisfying result of this patient.
Late stabilization surgery in flail chest and pulmonary contusion
Authors: Buana Andhika Citra , Habibie Yopie Afriandi , Muyasir Muyasir
Published: June 2021

Background: Traumatic thoracic injury is currently the second leading cause trauma-related death after head injury, and rib fracture are the most common of thoracic injury. Flail chest, as defined by the presence of three or more consecutive rib fractures in 2 or more places characterized by paradoxical motion of flailing chest wall. An associated injury directly related to flail chest is pulmonary contusion. Pulmonary contusion in turn is the most common injury in blunt thoracic trauma, occurring in 30% to 75% of all cases.Case Description: a 69-year-old woman was referred from the rural hospital to the Dr. Zainoel Abidin General Hospital emergency room with chief complains of unconsciousness since 3 days ago after collision. Patients had a motorcycle crush accident and loss of consciousness after the event. Clear airway, but there is a paradoxical motion at left chest wall. Crepitation found from palpation at left hemithorax. From the chest X-ray shown haemothorax, pulmonary contusion, multiple ribs fracture at 3,4,5,6,7,8 at the left hemithorax. From head CT Scan found cerebral oedema. Also closed fracture at left 1/3 medial radius ulna and tibia fibula medial. The patients were performed surgery for open reduction and internal fixation of the flail chest. Hospitalized in ICU afterwards, Unfortunately, the patients were died few days later due to intracerebral worsening.Conclusion: Flail chest which related with pulmonary contusion must be treated immediately. If it is accompanied by severe head injury, it will make the patient's prognosis worse, if we delay the diagnosis and treatment.Â
Diagnostic performance of APRI, RPR, FIB-4, GPR, AAR, and NLR in assessing the degree of liver fibrosis in patients with chronic hepatitis B
Authors: Kumbara Cokorde Istri Yuliandari Krisnawardani , Wibawa I Dewa Nyoman , Somayana I Gde , Suryadarma I Gusti Agung , Mariadi I Ketut
Published: June 2021

Background: This study aimed to compare the diagnostic performance of aspartate aminotransferase to platelet ratio index (APRI), fibrosis index based on four factors (FIB-4), red cell distribution width to platelet ratio (RPR), gamma-glutamyl transpeptidase to platelet ratio (GPR), aspartate aminotransferase and alanine aminotransferase ratio (AAR), and neutrophil to lymphocyte ratio (NLR) in assessing the degree of liver fibrosis in patients with chronic hepatitis B.Methods: A cross-sectional analytic study was done to analyze the data taken from the medical records of all chronic hepatitis B patients examined using TE at Sanglah Hospital Denpasar, Bali. Receiver operating characteristic (ROC) curve analysis was done to compare the resulting indices of accuracy for each biomarker.Results: From the total of 93 samples, it was found that the number of samples for each degree of fibrosis was 42 (45.16%) F0-1, 17 (18.27%) F2, 7 (7.52%) F3, and 27 (29.03%) F4. Significant differences for each degree of fibrosis (p<0.005) were found in APRI, FIB-4, RPR, GPR, and AAR score but not NLR (p = 0.897). Higher AUC and indices of accuracy were observed with more severe degree of fibrosis. GPR with the cut-off value of 0.367 for significant fibrosis, 0.559 for severe fibrosis, and 0.698 for cirrhosis had the greatest AUC and diagnostic accuracy.Conclusion: The diagnostic performance of GPR was better than other biomarkers, and the diagnostic accuracy increased along with an increasing degree of fibrosis. Future study on the applicability of GPR alongside APRI and FIB-4 in liver fibrosis assessment is needed.
Kualitas Bulir Cairan Caulerpa racemosa yang Disalut dengan Na-Alginat dan Ca-Laktat
Authors: Basmal Jamal , Nurhayati Nurhayati
Published: June 2021

Caulerpa racemosa mengandung serat, vitamin, antioksidan, polisakarida sulfat, sulfat bebas, dan mineral sehingga dapat dimanfaatkan sebagai pangan fungsional. Namun, cairan C. racemosa mudah mengalami kemunduran mutu selama proses penyimpanan dan transportasi, sehingga perlu dipertahankan mutunya dalam bentuk bulir. Perlakuan yang diberikan dalam proses penyalutan adalah variasi konsentrasi Na-alginat 0,4%; 0,6% dan 0,8% dan variasi larutan Ca-laktat 0,4%; 0,6% dan 0,8% yang diulang sebanyak tiga kali. Tujuan penelitian ini untuk menentukan kombinasi konsentrasi Na-alginat dan Ca-laktat terbaik dalam mempertahankan mutu bulir cairan C. racemosa. Hasil penelitian menunjukkan bahwa cairan C. racemosa mengandung mineral, serat pangan, dan asam amino baik esensial maupun non esensial dengan kadar air cairan C. racemosa sebesar 97,77%±0,02% dan setelah ditambah air dengan rasio 1:4, kadar airnya menjadi 99,6%±0,61%. Perlakuan konsentrasi Ca-laktat berpengaruh terhadap kadar air dan kadar abu bulir yang dihasilkan, sementara kadar serat kasar bulir dipengaruhi oleh perbedaan konsentrasi Na-alginat. Nilai terbaik berdasarkan kadar serat ditemukan pada perlakuan kombinasi Na-alginat 0,6% dan Ca-laktat 0,8% sebesar 4,05% dengan kadar air 97,22% dan kadar abu 0,65%.ABSTRACTCaulerpa racemosa contains fiber, vitamins, antioxidants, sulfated polysaccharides, free sulfates, and minerals so that it can be used as functional food. However, C. racemosa liquid deteriorates easily during storage and transportation, therefore it is necessary to maintain the quality of C. racemosa liquid in encapsulated form as grain. The treatments given in encapsulation process were variation of Na-alginat concentration i.e. 0.4%; 0.6% and 0.8%, and variation of Ca-lactate solution i.e. 0.4%; 0.6% and 0.8% which were repeated three times. The aim of the study was to determine the best combination of Na-alginate and Ca-lactate concentrations in maintaining the quality of encapsulated C. racemosa liquid grain. The results showed that C. racemosa liquid contained minerals, dietary fiber and amino acids, both essential and non-essential, with moisture content of 97.77±0.02%. After added with water with a ratio of 1:4, the moisture content of C. racemosa liquid was 99.6%±0.61%. The treatment of Ca-lactate concentration affected the moisture content and ash content of the liquid grain, while the crude fiber content was affected by Na-alginate concentration. The best value based on fiber content was found in the combination treatment of 0.6% Na-alginate and 0.8% Ca-lactate (A6K8) at 4.05%, with moisture content of 97.22% and an ash content of 0.65%.
Kandungan Fitokimia, Potensi Antibakteri dan Antioksidan Hasil Ekstraksi Caulerpa racemosa dengan Pelarut Berbeda
Authors: Marraskuranto Endar , Nursid Muhammad , Utami Swestri , Setyaningsih Iriani , Tarman Kustiariyah
Published: June 2021

Caulerpa racemosa merupakan rumput laut hijau yang mengandung senyawa aktif yang berpotensi sebagai antibakteri dan antioksidan. Perbedaan profil fitokimia dan bioaktivitas suatu ekstrak dipengaruhi oleh kepolaran pelarut ekstraksi. Penelitian ini bertujuan untuk mempelajari profil fitokimia, aktivitas antibakteri dan antioksidan ekstrak C. racemosa. Ekstrak diperoleh dari sampel segar C. racemosa yang dimaserasi menggunakan pelarut n-heksana, etil asetat, dan metanol. Uji antibakteri dilakukan dengan metode Resazurin Microtitter Assay (REMA) terhadap bakteri Escherichia coli dan Staphylococcus aureus. Aktivitas antioksidan diuji menggunakan metode 1,1-diphenyl-2-picrylhydrazyl (DPPH) dan Ferric Reducing Antioxidant Power (FRAP). Hasil penapisan fitokimia memperlihatkan bahwa ekstrak n-heksana mengandung alkaloid dan triterpenoid, sedangkan ekstrak etil asetat dan metanol mengandung alkaloid, flavonoid, tanin, fenol, dan steroid. Aktivitas antibakteri terbaik ditunjukkan oleh ekstrak etil asetat dengan nilai Minimum Inhibitory Concentration (MIC) terhadap E. coli sebesar 250 mg/mL. Ekstrak etil asetat C. racemosa juga memperlihatkan aktivitas antioksidan terbaik dengan nilai IC50 DPPH sebesar 110,7 mg/mL dan nilai FRAP sebesar 96,68 mmol Fe (II)/g. ABSTRACTCaulerpa racemosa is a green seaweed that contains active compounds that are potential for antibacterial and antioxidant. The phytochemical constituents and bioactivity of an extract depend on the extraction solvent polarity. This study aimed to determine the phytochemical profiles, antibacterial and antioxidant activity of C. racemosa extracts. Extracts were obtained from the fresh C. racemosa samples that were macerated with n-hexane, ethyl acetate, and methanol. Antibacterial assay was tested by Resazurin Microtiter Assay (REMA) method against Escherichia coli and Staphylococcus aureus. Antioxidant activity was determined using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and Ferric Reducing Antioxidant Power (FRAP) method. Phytochemical screening showed that n-hexane extract contained alkaloid and triterpenoid, while ethyl acetate and methanol extracts contained alkaloids, flavonoids, tannins, phenols, and steroids. The most active extract in the antibacterial assay was ethyl acetate extract with a Minimum Inhibitory Concentration (MIC) value of 250 mg/mL against E. coli. Ethyl acetate extract of C. racemosa also showed the best antioxidant activity where the IC50 of DPPH value was 110.7 mg/mL and the FRAP value was 96.68 mmol Fe(II)/g.
Immediate Rehabilitation of the Severely Atrophic Maxilla Using Trans-Sinus Nasal Protocol and Extended Length Subcrestal Angulated Implants. Case Series With 1-Year Follow-Up
Authors: Zaninovich Michael
Published: June 2021

Immediate fixed full-arch rehabilitation of the severely atrophic maxilla eliminates use of a tissue-supported prosthesis during the healing phase and maximizes patient comfort and quality of life. The surgical treatment options available for immediate rehabilitation of the severely atrophic maxilla are dependent on the location and availability of the residual alveolar ridge. When bone is only available in the intercanine region, a graftless approach using tilted distal implants may not provide adequate distance between implants for favorable biomechanics. Subsequently, zygomatic implants are the alternative to provide adequate posterior occlusal support. Use of extended length subcrestal angulated implants offers an additional implant option for the clinician to restore the severely atrophic maxilla immediately. The treatment protocol involves anchorage of the implant fixture to the lateral wall of the nasal bone. The distally tilted implant transverses an augmented sinus cavity and extends to the site of the first permanent molar. The novel implant subcrestal angulation and use of a multi-unit abutment promotes passivity of fit of a full-arch fixed immediate prosthesis. Five clinical case reports from private practice are presented that outline the clinical value of the novel implant design in the rehabilitation of the severely atrophic maxilla. In each case, the use of zygomatic implants would be the only alternative to provide an immediate fixed prosthesis due to the absence of residual alveolar bone in the maxilla premolar and molar regions. The use of extended-length subcrestal angulated (ELSA) implants with straight or angulated multiunit abutments have successfully restored the maxillary arch immediately.
Accuracy Evaluation of the Computer-Designed Selective Laser Sintering Surgical Guide for Flapless Immediate Loading Dental Implants Surgery in Edentulous Jaws
Authors: de Almeida Prado Di Giacomo Giovanni , Cury Patrícia , da Silva Airton Moreira , da Silva Jorge Vicente Lopes , Pompeo Souto Carlos Eduardo , Martines Rodrigo Tadashi , Ajzen Sergio
Published: June 2021

This study was designed to evaluate the accuracy of a novel computer-designed and selectively laser sintered surgical guide for flapless dental implant placement in the edentulous jaw. Fifty dental implants were placed in 11 patients with at least 1 totally edentulous jaw. Initially, cone-beam computed tomography (CBCT) was performed in each patient to define the virtual position of the dental implants based on the assessment of bone availability and the proposed dental prosthesis. After virtual planning, 3D surgical guides were printed using selective laser sintering. CBCT was repeated after the surgery, and the pre- and postoperative images were overlapped in computer-assisted design software to compare the planned and actual positions of the dental implants using a 1-sample t test. The mean ± angular standard deviation between the long axes of the planned and final dental implant positions was 4.58° ± 2.85°; the linear deviation in the coronal position was 0.87 ± 0.49 mm and in the apical region of the dental implants was 1.37 ± 0.69 mm. These differences were statistically significant (P < .001). The proposed modifications reduced the deviations, resulting in an improvement in the technique. We were able to place implants and temporary prostheses using the present protocol, taking into account the differences between the planned and final positions of the dental implants.
Comparison of Implant Stability Between Conventional Drilling and Piezosurgical Implant Bed Preparation Techniques
Authors: Kjaergaard Martin , Nguyen Vinh Giap , Brandt Jan , Pouchet Joanne , Weigl Paul Martin
Published: June 2021

This prospective study compared the stability of implants placed using piezoelectric surgery (piezo group) and those placed using conventional rotary drills (bur group) during the first 90 days postoperatively. Teeth in the posterior maxillary regions of 21 patients were randomly assigned to 2 groups. The implant stability quotient (ISQ) was measured at days 0, 7, 14, 21, 28, 42, 56, and 90 postoperatively. Twenty-eight of 29 implants were successfully integrated at day 90 (1 implant in the test group was lost). Although both groups showed a significant overall increase in implant stability with time (P < .0001) and a high final mean ISQ value, no statistically significant difference in stability was seen between the groups. The bur group showed greater variance in ISQ values than the piezo group did (P < .001) at all time points. Long-term studies with larger samples are needed to investigate the bone response to the use of piezoelectric surgery for implant preparation.
A Zygomatic Bone Study Using Virtual Dental Implant Planning Software
Authors: Moro Sidnei Antonio , Thomé Geninho , Padovan Luis Eduardo Marques , da Silva Ricarda Duarte , Tiossi Rodrigo , Fontão Flávia Noemy Gasparini Kiatake
Published: June 2021

This study evaluated the anatomical factors that influence the virtual planning of zygomatic implants by using cone-beam computerized tomography (CBCT) scans. CBCT scans of 268 edentulous patients were transferred to specialized implant planning software for the following measurements: maxillo-sinus concavity size (small, medium, and large), zygoma width, implant insertion angle, implant length, and implant apical anchorage. Concavity sizes found were as follows: 34.95% small, 52.30% medium, and 7.35% large. The mean insertion angle was 43.2 degrees, and the average implant apical anchorage was 9.1 mm. The most frequent implant length was 40 mm. Significant differences were found when the different types of concavities in relation to the installation angle, the distance of the apical portion of the implant in contact with the zygomatic bone, and the lateral-lateral thickness of the zygomatic bone were compared (P < .001). Medium-sized maxillary sinus concavity presented greater apical anchorage of the implant (9.7 mm) and was the most frequent type (52.30%). The zygomatic bone is a viable site for zygomatic fixtures, and the use of specialized implant planning software is an important tool to achieve predictable outcomes for zygomatic implants and allows good visualization of the relation between implants and anatomical structures.
An Unusual Case of Early Dental Implant Failure in an Otherwise-Healthy Patient due to Actinomycosis
Authors: Parlak Hanife Merva , Akman Abdullah C. , Comerdov Elnur , Kosemehmetoglu Kemal , Inkaya Ahmet Cagkan , Keceli H. Gencay
Published: June 2021

Actinomyces species are members of normal oral flora that may give rise to a rare disease—oral actinomycosis. Presented herein is a case of early implant failure associated with actinomycosis in an otherwise healthy 43-year-old female and the treatment adopted after explantation. Clinically, 1 month after the implant placement, the peri-implant soft tissues were hyperplastic and associated with an excessive tissue reaction, bleeding, suppuration, deep probing depth, and implant mobility of #19 and #20 implants. Both implants were removed and all granulomatous tissues were thoroughly debrided. Histopathological examination revealed signs of acute ulcerative inflammatory reaction and Actinomyces colonies. The patient was prescribed short-term oral penicillins. Six months after explantation, the deficient bone was augmented using a combination of absorbable collagen membrane, autogenous block bone, and xenograft. The patient was followed for 1 year; and subsequently, 2 implants were re-inserted at the same positions. The patient was followed and no recurrences were observed. Implant failure due to actinomycosis is an extremely rare condition, and a definitive diagnosis is therefore essential for successful treatment.
Heat and Sound Generation During Implant Osteotomy When Using Different Types of Drills in Artificial and Bovine Bone Blocks
Authors: Limmeechokchai Sunee , Kan Joseph Y. , Rungcharassaeng Kitichai , Goodacre Charles J. , Lozada Jaime , Oyoyo Udochukwu
Published: June 2021

The purpose of this study was to compare heat and sound generated during implant osteotomy when different types of drill were used in artificial bone and bovine bone blocks. A total of 80 implant osteotomies were formed using 4 implant drilling systems: N1 (OsseoShaper) (Nobel), NobelActive (Nobel), V3 (MIS), and BLX (Straumann) in both artificial bone and bovine bone blocks. Thermocouple probes were used to record temperature change at the depths of 5.0 mm and 13.0 mm of each implant osteotomy formed by the final drill. In addition, thermographic images, drilling sound, and drilling time were recorded and evaluated. Statistical analyses were performed at α = 0.05. The mean temperature changes as recorded by thermocouple probes and thermocamera were significantly lower in OsseoShaper than most other drill-bone combinations (P < .05). The mean drilling times and sound generation for OsseoShaper were significantly higher and lower than most other drill-bone combinations (P < .05), respectively. Minimal heat and sound generation can be expected when implant osteotomies are performed using OsseoShaper at a low rotational speed (50 rpm) even without irrigation. However, extended drilling time is required.
Effect of Anterior Implant Position on Biomechanical Performance in the Maxillary All-on-Four Treatment: A 3-D Finite Element Analysis
Authors: Sezer Taygun , Kilic Kerem , Esim Emir
Published: June 2021

In the all-on-four concept, the positions of both posterior and anterior implants can affect stress distribution. The aim of this study was to examine the effect of the position of anterior implants on stress distribution in the implant, the bone around the implant, and prosthetic components in the resorbed maxilla using the all-on-four concept. All-on-four designs were prepared with 3 different anterior implant positions in a fully edentulous maxilla. Anterior implants were placed axially in the central incisor area in model 1, in the lateral incisors area in model 2, and in the canine area in model 3, forming 3 groups. The von Mises and principal stresses in the bone tissue and the von Mises stresses in the implant and prosthetic components were evaluated by 3-dimensional finite element analysis. There were more stresses on the cortical bone than trabecular bone. The stresses on the bone tissue and implant components were generally concentrated around the posterior implant, whereas the stresses on the prosthetic components were generally concentrated in the anterior region. Changing the anterior implant positions from the central tooth to the canine tooth reduced the stress on the bone around the implant. The highest von Mises stresses occurred in the prosthetic superstructure in all models, whereas the lowest stresses occurred in the trabecular bone. Changing the position of the anterior implants from the central tooth to the canine area in the maxillary all-on-four concept created a favorable stress distribution.
Procedural generation of problems for elementary math education
Authors: Xu Yi , Smeets Roger , Bidarra Rafael
Published: June 2021

Mathematics education plays an essential role in children’s development, and there are many online applications aimed at supporting this process. However, manually creating math problems with a variety of textual and visual content is very time-consuming and expensive. This article presents a generic approach for procedural generation of mathematical problems, including their corresponding textual representations. The content generation process consists of two phases: abstract math problem generation and text generation. For the generation of abstract math problems, we propose a generic template-based method that operates across a variety of difficulty-levels and domains, including arithmetic, comparison, ordering, mathematical relationships, measurement, and geometry. Subsequently, we propose a multi-language adaptive textual content generation pipeline to realize the generated abstract math problems into semantically coherent text questions in natural language. A workflow time gain evaluation shows that the system yields an average time saving of 56%. Further, human expert evaluation of this approach indicates that the content it generates is sensible and solvable for primary school students.
Serious board games: modding existing games for collaborative ideation processes
Authors: Sousa Micael
Published: June 2021

Modern board games are booming, exploring new design elements, and providing dynamics that can support unique experiences. Serious game approaches can benefit from these insights and novelty. With the appropriate adaptation, modern board games may become flexible and cheaper ways to use and prototype serious games. Exploring these games and player engagement can support digital game design. Digital game designers may learn from modern board games to playtest player engagement and build prototypes for their serious games. This paper describes an experience with several adapted modern board games aiming to create a “Light Collaborative Ideation Process”, supported by the “Engagement Design” model and “The big five personality traits”. The game session objectives concerned fostering collaboration and ideation among participants in an informal meeting. The session successfully supported the potential of using modern board games, although showing the limitations and future developments required to benefit from the modding approach.
Yerel Halkın Milli Parklara Yönelik Çevresel Kimlik, Çevresel Tutum ve Katılım Yaklaşımları
Authors: AKKUŞ Çetin , YORDAM Selda
Published: June 2021

Milli parklar sahip olduğu doğal ve kültürel değerler yönüyle korunması gereken alanlar arasında bulunmaktadır. Bu alanların sürdürülebilirliğini sağlamak, ekosistemlerini ve biyolojik çeşitliliğini başarılı bir şekilde korumak için yerel halkın katılımı önem arz etmektedir. Türkiye’de toplam 45 milli park bulunmaktadır. Kastamonu ise bu parkların üçüne ev sahipliği yapmaktadır. Bu araştırmada, milli parklara yönelik çevresel kimlik, çevresel tutum ve katılım ilişkisinin Yapısal Eşitlik Modellemesi ile çözümlenmesi amaçlanmıştır. Bu amaç doğrultusunda Kastamonu yerel halkından kolayda örnekleme yöntemiyle 399 katılımcıya ulaşılmış ve anket uygulanmıştır. Analizler sonucunda çevresel kimliğin çevresel tutumu, çevresel tutumun da katılımı etkilediği tespit edilmiştir. Bununla beraber yerel halkın doğal alanları ziyaret etme sıklığı, doğa koruma derneğine üye olma durumu, memleketi ve ilde yaşama süresinin çevresel kimlik, çevresel tutum ve katılım boyutlarına göre istatistiksel açıdan anlamlı farklılıklar gösterdiği tespit edilmiştir.
Effective tracking of nationally determined contributions: A case study on South Africa
Authors: Ross K. , Winkler H.
Published: June 2021

The Paris Agreement’s enhanced transparency framework requires that all Parties track and report progress toward their nationally determined contributions (NDCs). This paper develops a qualitative, multi-criteria framework that can be used to either design effective NDC tracking systems or evaluate the extent to which Parties are prepared for NDC tracking. The paper also applies the framework to a case study on South Africa, with results indicating that the country is progressing well in terms of selecting appropriate indicators, enacting legislation, and enhancing transparency. In areas of collecting data, reporting on socio-economic outcomes, and making changes in national policy, there is room for improvement, and the paper explores options to this end. Since South Africa has a relatively advanced system for tracking mitigation goals, the findings of the paper suggest that other developing country Parties may require additional resources and capacity to track NDCs effectively.
The extent, characteristics and potential of solar powered irrigation systems in South Africa
Authors: Piliso P. , Senzanje A. , Dhavu K.
Published: June 2021

South Africa has been identified as having a high potential for solar powered irrigation. However, there has been a lag in the development of solar powered irrigation systems (SPIS) there, mainly due to the high investment cost associated with solar technology. South Africa has frequently implemented load shedding, which has affected many farmers. The work reported in this paper sought to determine the extent of solar powered irrigation and characteristics of the system types in use. The extent of SPIS in South Africa was determined using a questionnaire, and categorised in terms of farm size, SPIS configuration (storage of energy), type of irrigation, and location of the system. These were established mainly from a literature search. The questionnaires were administered on Survey Monkey®. The sample size of the study was 138 755 potential respondents. The number that participated and completed the questionnaires included a total of 18 SPIS engineers, installers and designers and 13 SPIS users (farmers). The main problem encountered with the distribution of the survey was finding SPIS users to participate. Results from SPIS engineers, installers and designers showed that most SPIS they implemented were in the Western Cape and the Eastern Cape, at 33% of the responses for both provinces. The total area under SPIS was found to be 364 ha, while the area under irrigation is South Africa is 1 300 00 ha, indicating a high potential for SPIS development. Some details on the extent of SPIS in South Africa were determined in this paper, but more SPIS users need to be identified to determine the details of their SPIS.
"We've been taught to understand that we don't have anything to contribute towards knowledge": Exploring academics' understanding of decolonising curricula in higher education
Authors: Hlatshwayo Mlamuli Nkosingphile , Alexander Innocentia
Published: June 2021

Universities in the Global South continue to grapple with the ethical demands of decolonising and transforming the public university and its episteme orientations. In this paper, we contribute to the emerging body of work in the Global South that attempts to make sense of the transformation and decolonisation discourses by exploring academics' understanding of decolonising curricula in South African higher education. Using purposive sampling, we interviewed eight academics from the school of education who teach in a research-intensive university in KwaZulu-Natal, South Africa. We relied on the field theory of Pierre Bourdieu to think through the notion of a research-intensive university being a contested and structuring field constituted of various actors and agents who are struggling to make sense of, and understand the calls for, decolonising and transforming curricula. The findings suggest that, largely, academics understand the decolonising of curricula as a response to the need to tackle and theorise the Eurocentric thought in curricula and to re-centre African epistemic traditions and as well as navigate what they refer to as the confusion, ambiguity, and discomfort of decolonisation. We end this paper with some empirical and theoretical reflections on how exploring academics' understanding of decolonizing curricula is central to the broader project of achieving social justice in the Global South.
Exploring students' experience and perceptions of the Somatology extended curriculum programme at the Durban University of Technology
Authors: Makgobole Mokgadi Ursula , Onwubu Stanley Chibuzor
Published: June 2021

The South African Higher Education (HE) sector has faced scrutiny in recent years because of its low participation and high attrition rates. In an attempt to address this, institutions have introduced additional programmes such as Extended Curriculum Programmes (ECPs). In this study, we followed an interpretive research paradigm to explore students' experiences and perceptions of the somatology ECP at the Durban University of Technology DUT). Semi-structured interviews were conducted with 15 individual students out of the 69 graduates of the somatology ECP. The participants believe that social integration and reduced academic workload over an extended period contributed to their academic performance. The participants felt that support subjects such as writing skills and computer literacy and the work done by staff and mentors of the ECP facilitated their academic success. The findings from the study suggest that the somatology ECP was successful, too, in the social integration of students while preparing them for success.
Exploring Grade 6 mathematics teachers' use of the language of learning and teaching in assessment for learning
Authors: Mahlambi Sizwe B , Mawela Ailwei S
Published: June 2021

In this study, we aimed to explore Grade 6 mathematics teachers' use of English, the language of learning and teaching in assessment for learning in selected primary schools in Alexandra Township, South Africa. From Grade 4, English is the language of teaching and learning for most learners, despite English being the home language of a minority of learners. Results of studies have shown that in South Africa, in Grades 1 to 3, in which learners are taught using their home-language performance appears to be better than in Grades 4 to 6 where English as a First Additional Language (EFAL) is used for teaching and learning. Guided by qualitative case study design, we used semi-structured interviews and non-participatory observation to collect data from nine purposefully sampled Grade 6 mathematics teachers. In conjunction with the literature reviewed and the theory underpinning the study, we used themes to analyse, interpret, and discuss the data we collected. This research revealed that learners in Grade 6 struggle to understand English as the language of learning and teaching, so, to augment concept development and understanding, teachers and learners use code-switching. In the classrooms observed, this practice has become the norm to improve the performance of learners with limited language proficiency. However, because of the differences between the home language of learners and that of teachers in mathematics classrooms, code-switching is often not enough to ensure understanding.
JOHN FOWLES’UN BÜYÜCÜ’SÜ: SEVGİDE KEŞFEDİLEN ‘BEN’LİK
Authors: AŞKAROĞLU Vedi
Published: June 2021

John Fowles’un Büyücü romanı, Yunan adası Phraxos’ta İngilizce öğretmeni Nicholas Urfe’ün cinsellik ve kendini arayış izlekleri çerçevesinde kadın-erkek ilişkilerini, sorumluluk duygusunu, aşkı ve sevgiyi irdeler. Başlangıçta kadınlar ve cinsellikle ilgili sorumsuzca davrandığını açık yüreklilikle dile getiren Nicholas kendine göre duygusallıktan, sorumluluktan ve aşık olmaktan kaçan birisidir. Kadınlarla çok uzun bir ilişki sürdürmez, aynı şehirde bile bulunmaktan kaçınır ve kısa sürede yeni bir ilişkiye başlayarak öncekini arkada bırakmaya çalışır. Ancak bu davranış kalıbını kıran Avustralyalı genç bir kadın olan Alison’dur. Nicholas, Yunanistan’a gitmeyi duygusallıktan uzaklaşmak ve yeni bir başlangıç yapmak için ister. Orada çok zengin ve gizemli Conchis ile tanışır. Kendini mitolojik figürler, tiyatro, dans, müzik ve cinsellikle örülü büyülü bir oyunun içinde bulur. Oyun onun duygularının sadeleşmesi, aşkı yeni gözlerle görmesi ve sorumluluğu alacak kadar olgunlaşması ile son bulur. Yaşadığı içsel yolculuk onu Alison’la yeniden saf sevgi ile bir araya getirecektir. Bu makalede, postmodern romanın önemli bileşenlerinden birisi olan oyun ögesinin kişiliğin oluşumundaki rolü irdelenecektir. İki katmanlı bir oyunun sergilendiği Büyücü romanında ilk katman anlatım tekniği olarak postmodern oyun incelenecek, aynı zamanda romana adını veren Conchis’in romanın içeriğinde Nicholas’ı eğitmek ve modernist Viktoryen özelliklerle elde ettiği dünya algısını kırmak amacıyla Julie/ Lily gibi diğer kişilerle gerçekleştirdiği cinsellik ve gizemcilik oyununun etkileri ele alınacaktır. Makaledeki ana amaç Nicholas’ın iç dünyasına ve kendini tanımasına doğru giden yolculuğunu cinsellik, kadın algısı, aşk, sevgi ve sorumluluk izlekleri etrafında postmodern oyun unsuru ile bağlantılı biçimde çözümlemektir.
Parsing of NLM metadata in OpenRefine from OJS articles v1
Authors: Moi Alessandra , not provided carlo.bianchini , Marchitelli Andrea
Published: June 2021

Protocols for parsing metadata of articles harvested from Open Journal Systems (OJS) in order to create entities in WikiData
Bacterial Isolation of Mycobacterium avium v1
Authors: Komatsu Tetsuya
Published: June 2021

Mycobacterium avium subsp. hominissuis (MAH) is one of the most important agents causing non-tuberculosis mycobacterial infection in human and pigs. Genome analysis on MAH of human isolates has been proceeding, however, those of pigs are limited despite its potential source of infection to human. Here, we isolated MAH from pig lymph nodes or livers and obtained their genomes.
Rapid Sequencing Wet Lab v1
Authors: E Gorzynski John
Published: June 2021

Aim: To prepare an ONT non-barcoded library using LSK109, to be distributed over 48 flow cells from 2ml of whole blood.
NİKSAR’IN DÂNİŞMENDLİ DEVLETİ HÂKİMİYETİNE GİRMESİ VE BU DÖNEMDE NİKSAR’DA MEYDANA GELEN BAZI SİYASİ OLAYLAR HAKKINDA
Authors: Turan İsmail
Published: June 2021

Niksar, tarih öncesi dönemlerden itibaren Anadolu’da önemli yerleşim yerlerinden biri olmuştur. Bulunduğu stratejik konumu şehrin önemini daha da arttırmıştır. Coğrafi konumu nedeniyle her dönemde egemen güçlerin ilgisini çekmiş ve siyasi oluşumlar buraya hâkim olma mücadelesi vermişlerdir. Nitekim Malazgirt Zaferinden sonra (26 Ağustos 1071) Anadolu’da Türk fetihlerinin başlamasıyla birlikte Niksar, Büyük Selçuklu Devleti hükümdarı Alp Arslan’ın komutanlarından Dânişmend Gazi tarafından fethedilmiş ve Dânişmendliler Devleti’nin başkenti olmuştur. Dânişmendli hâkimiyetinde olduğu zaman içerisinde Niksar’da bazı siyasi olaylar meydana gelmiştir. Bu siyasi olaylar, Niksar’ın bulunduğu bölgenin stratejik yapısıyla yakından ilgili olmuştur. Zira Niksar’a hâkim olan ve özellikle burada bulunan Niksar Kalesi’ne hükmeden bir siyasi veya askerî güç, dolayısıyla Orta Anadolu’ya ve Karadeniz Bölgesine hâkim oluyordu. Çünkü Niksar, bölge coğrafyası için bir kilit noktada bulunmaktadır. Çalışmamızda öncelikle Niksar’ın hangi durum ve şartlarda fethinin gerçekleştiği üzerinde durulmuş daha sonra ise Dânişmendliler hâkimiyetinde bulunduğu zaman boyunca Niksar’da cereyan eden bazı siyasi olaylar ele alınmış bu olayların nedenleri ve sonuçları üzerinde durulmuştur.
Big Data Predictive Analytics and Performance: The Role of Transformational Leadership
Authors: Et. al. Collins Ngu Nji,
Published: June 2021

The importance of Big Data and Predictive Analytics (BDPA) have been overemphasized in recent years. However previous studies have been so focused on the developed and emerging market economies. The present research investigates this concept within the settings of a developing market economy. Also, the influence of transformational leadership (TL) in the adoption of BDPA as well as its moderation role between BDPA-Operational Performance (OP) nexus hasn’t been raised in prior studies. To address this, this study examines the combined effects of  Mimetic Pressures (MP) and the Firm’s Human Skills (HS) as well as TL in the adoption of BDPA. The present study also examines the impact of TL on OP and its moderating role on the BDPA-OP nexus. Using a pre-tested questionnaire, the research hypothesis was tested on 145 surveys. The results of the empirical study indicate that MP has a positive but insignificant effect on the building and selection of HS and independently the adoption of BDPA is positively and significantly been influenced by both MP and HS. Likewise, BDPA has a positive and significant impact on OP. TL has a positive but insignificant effect in the adoption of BDPA and a negative and insignificant effect on OP. Also, the moderating effect of TL in the BDPA-OP nexus was found to be positive and seemingly significant.
Effect of Social Media on Learning Effectiveness: Examining the mediating role ofthe Socialization, Externalization, Combination, Internalization and knowledgesharing.
Authors: Et. al. R Hemalatha,
Published: June 2021

This study examines the mediating role of Nonaka’s knowledge spiralsof SECI.Whetherthishasarelationshipwiththeeffectofsocialmediaonknowledgesharingandexamines whether it leads to effective learning. The effect on knowledge sharing through socialmedia which was constructed by Bock et al. (2005) has been used for measuring in this study. Themediating role of SECI on social media and knowledge sharing for effective learning has beenassessed based on the four dimensionsSECI multi-dimensional questionnaire offered by Nonakaet al. (2000) has been used for this study. The results reveal which of the four dimensions of Nonaka's that, which has a significant impact on effective learning using social media & knowledge sharing that has been brought to light from this study. The empirical findings of thisstudymayenable toenrichthetheoreticaland practicalimplications.
Challenges& Prospectus Of Women Enterpreneurs In India
Authors: Et. al. Dr.V.MAHESWARI,
Published: June 2021

Women Entrepreneurship play an important role in an economic growth. In India, though women are playing key role in the society but still their entrepreneurial ability has not been properly tapped due to the lower status of women in the society. In man oriented society, women want to prove him and created equality and democratic approachand also discusses various programs taken by government for women entrepreneurship development. This paper has been made to study about the status of women entrepreneurs and the challenges faced by them when they set up and managed their own businesses of business environment. This study is based on secondary data and primary data which is collected through questionnaire among 100 respondents in Madurai and data were analysed the reasons behind women entrepreneurs’ success and failures withHentry Garret Rankingwere used to identify themInfluencing factors on women Entrepreneurs and how to overcome that.
Skleroderma hastalarının ağız ve periodontal bulguları ile hastalık tutulumları arasındaki ilişki
Authors: ÖZCAN Mustafa , CİFTCİ Volkan , TÜRK İpek
Published: June 2021

Amaç: Bu çalışmanın amacı, skleroderma (SD) hastalarının mevcut ağız açıklığını ve periodontal bulgularını tespit etmek ve bu bulgular ile hastalığın alt grupları arasındaki ilişkiyi değerlendirmektir.

Gereç ve Yöntem: Çalışmaya 74 yetişkin (60 kadın, 14 erkek) skleroderma hastası dahil edildi. Çalışma grupları skleroderma tipine (51 Diffüz, 23 lokalize) göre belirlendi. Çalışmaya katılan hastaların klinik periodontal parametreleri (Gingival indeks, plak indeksi ve cep derinliği) kaydedildi. Maksimum ağız açıklığı ve tükürük miktarı belirlendi. Temporamandibular eklem muayenesi yapıldı.

Bulgular: Skleroderma hastalarında ortalama ağız açıklığı 36,6±8,0 mm tespit edildi. Diffüz tip SD hastalarının ortalama ağız açıklığı (33,7±7,3 mm) ve lokalize tip SD hastalarının ağız açıklığı (43,0±5,4 mm) arasında istatistiksel olarak anlamlı bir fark bulundu. Diffüz tip SD hastalarında cep ortalama cep derinliğinin (3,17±0,9), lokalize tip SD hastalarına (2,69±0,6) göre istatistiksel anlamlı düzeyde yüksek olduğu tespit edildi.

Sonuç: Sklorederma yaygın olarak sınırlı ağız açıklığına ve periodontal dokulara etkisi nedeniyle çeşitli oral problemlere yol açabilir. SD hastalarının oral problemlerinin tedavisinde, ağız açma egzersizleri ve düzenli diş hekimi kontrolü önerilebilir. Ayrıca SD tipleri ile periodontal hastalıklar arasındaki ilişkinin etiyolojisi ve patogenezini değerlendiren ileriki çalışmalara ihtiyaç bulunmaktadır.