bluuebunny/crossref_metadata_2025 huggingface dataset:
O JUIZ E O PROGRESSO
Authors: Trigueiro Victor Guedes , Godoy Arnaldo Sampaio de Moraes
Published: February 2022

Neste ensaio serão analisados criticamente os julgamentos da Ação Direta de Inconstitucionalidade por Omissão 26 e do Mandado de Injunção 4733, proferidos pelo Supremo Tribunal Federal, que tornaram crime a homofobia. O julgamento do caso pode ser analisado sob a perspectiva do que se convencionou denominar de ativismo judicial, um comportamento característico (mas não exclusivo) de Cortes Constitucionais, e da judicialização da política, fenômeno presente em diversas democracias contemporâneas, que desloca para o Poder Judiciário o centro de gravidade das decisões políticas fundamentais, a partir da constatação de um comportamento omissivo do Poder Legislativo e do Poder Judiciário. Para além disso, a discussão envolve a discricionariedade judicial na interpretação da norma, tema remete a um dos debates acadêmicos mais famosos da teoria geral do direito contemporânea, travado entre Herbert Hart e Ronald Dworkin. Pretende-se demonstrar que o caminho adotado pela Suprema Corte extrapolou os limites da atuação jurisdicional, vulnerando o equilíbrio entre o Poder Judiciário e o Poder Legislativo e ferindo o texto expresso da Constituição Federal.
Sozialpolitik für die Soziale Arbeit
Authors: Fehmel Thilo
Published: February 2022

This second, updated and expanded edition of the book provides an introductory overview of social policy and the system of social security in Germany, focusing in particular on social work as an aspect of social policy. Basic social mechanisms of redistribution and social security are explained, theories of the welfare state are presented, and the history of German social policy is traced in its main features. The volume focuses on a detailed description of the structure of the German welfare state. The various pillars of the welfare state (social insurance, social compensation, social assistance, social promotion) are discussed, as are the various levels of social policy institutions (federal, state, local, associations). Another focus is on recent socio-political developments (transformation of welfare production) in their respective significance for social work as a discipline and profession.
Telekommunikationsüberwachung in Strafsachen
Authors: Machado Luís Henrique
Published: February 2022

The main purpose of this paper is to contribute to the development of the transfer of evidence from interception measures between Germany and Brazil. In order to determine whether a transfer of evidence is feasible, the most important legal issues concerning the interception of telecommunications are highlighted and the particularities of the German and Brazilian legal systems are elaborated. For this purpose, it was necessary to examine the laws, doctrine and case law for both countries and to identify similarities and differences. As a result, this study not only fulfills academic purposes, but also prepares the material specifically for forensic practice.
Tea Value Chains Viability in Limpopo Province of South Africa: A Cost-Benefit Analysis
Authors: E. Nesamvuni Azwihangwisi , Bokosi James , A. Tshikolomo Khathutshelo , S. Mpandeli Ndivhudzannyi , Nesamvuni Cebisa
Published: February 2022

The research was conducted to investigate the production of value-added tea as part of the resuscitation of Tshivhase-Mukumbani Tea Estate. Data were mainly obtained from records kept at the Tshivhase-Mukumbani Tea Estate, through a review of literature and interviews of the selected respondents. Evaluation of economic viability of the value-adding initiative was based on Net Present Value (NPC) and the Benefit-Cost Ratio (BCR) calculated from time-series data obtained for the period 2005–2012. The quantity of value-added tea produced varied across years, geographical locations, and seasons, with production higher for wetter seasons. The NPV was consistently negative, while the BCR was below unity throughout the study period, implying that the value-adding initiative was economically not feasible. Initiatives for achieving economic sustainability of the value addition were (1) Improve the marketing of the made tea brand Midi Tea as organic and longer shelf life. (2) Good labor contracting management practices to deal with labor disputes and unrest. (3) Good supply chain and procurement management practices to reduce the cost of production (4) Monitoring the impact of climate variability and mitigate by providing irrigation (5) Intercropping tea with a suitable winter yielding crops such as avocadoes or Macadamia.
Sleep in Parkinson’s Disease Dementia
Authors: Chow Matthew
Published: February 2022

Sleep disruption and daytime somnolence are common in Parkinson’s disease dementia (PDD). In this condition, the clinical features of Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) converge. Both PD and DLB populations have different sleep disturbances that are amplified when combined. Hence, sleep disruption is often significant and multifactorial in PDD. It is proposed that sleep–wake neural networks are affected early in the neurodegenerative process. The resultant lack of sleep results in impaired clearance of toxic metabolites, hastening disease progress. As the motor and nonmotor symptoms of PDD worsen, sleep becomes more disturbed. Medications used to control these symptoms can be sedating or cause insomnia. Comorbid sleep disorders are also often present. All of these factors contribute to poor sleep in these patients. Management is centered on symptom control, quality of life, and treatment of comorbidities.
Pseudomonas prosekii isolated in Antarctica inhibits plantpathogenic strains of Pseudomonas viridiflava and Pseudomonas fluorescens
Authors: Snopková Kateřina , Dufková Kristýna , Šmajs David
Published: February 2022

Pseudomonas-caused plant diseases are present worldwide and affect most of the major lineages of higher plants which, as a consequence, may result in significant economic losses. Despite the use of bacteriocins produced by rhizosphere and soil bacteria has been nowadays considered as novel crop protection approach, antagonistic interactions of cold-adapted isolates toward agriculturally important phytopathogenic bacteria have not been studied yet. In this study, we tested inhibition activity of Antarctic Pseudomonas spp. against phytopathogenic pseudomonads. Four Antarctic stains (P. prosekii CCM 8878, CCM 8879, and CCM 8881 and Pseudomonas sp. CCM 8880) inhibited several phytopathogenic strains of P. viridiflava and P. fluorescens. Based on inhibition zone character and previous genome research we suggest that L-pyocin activity was responsible for this effect against P. viridiflava strains and that tailocin inhibited P. fluorescens isolate.
DNA barcoding of Aphelopus Dalman (Hymenoptera, Dryinidae) from China, with descriptions of four new species
Authors: Olmi Massimo , Chen Hua-Yan , Guglielmino Adalgisa , Ødegaard Frode , Vollaro Massimo , Capradossi Leonardo , Liu Jing-Xian
Published: February 2022

Species of the genus Aphelopus Dalman (Hymenoptera, Dryinidae) are important natural enemies of leafhoppers. The genus is relatively diverse in China, with 35 recorded species. In order to further make use of these important parasitoids in biological control programs, species of Aphelopus collected across China are studied using an integrative approach (combined DNA barcoding and morphology). Of the 17 studied species, two are newly recorded from China: A. nivealis Mita & Olmi, 2014 and A. prolatus Mita & Olmi, 2014, and four are described as new to science: A. incognitus Chen, Olmi & Guglielmino sp. nov., A. maculiala Olmi, Chen & Ødegaard sp. nov., A. taianensis Olmi, Ødegaard & Chen sp. nov., and A. zaifui Olmi, Chen & Liu sp. nov. The total number of Aphelopus species known from China is raised from 35 to 39. Keys to the Oriental and Eastern Palaearctic species of Aphelopus are modified to include the new species. Application of DNA barcoding in the species delimitation of Dryinidae is discussed.
Significance of C-reactive protein determination in patients with metabolic syndrome
Authors: Miljković Dušan , Todorović Slađana
Published: February 2022

Objecive. Previous research has shown that CRP is elevated in patients with metabolic syndrome (MS) and that low-intensity inflammation is a characteristic of MS. The aim of this study was to determine the concentration of CRP and to examine the significance of elevated CRP in MS patients. Methods. The study included 149 outpatients, 67 patients with MS (68.9 ± 8.7 years) and 82 subjects who were in the control group of the appropriate age (68.9 ± 8.6 years) (p> 0.05). CRP was determined by turbidimetry and the reference range was up to 5.0 mg / L. Results. The average CRP concentration for MS patients was 5.33 ± 3.60 mg / L, while in the control group the CRP concentration value was 4.60 ± 2.03 mg / L (p <0.001). There was no significant difference in CRP concentrations between men (6.02 ± 4.88 mg / L) and women with MS (4.97 ± 2.87 mg / L) (p> 0.05). Almost a third of patients (29.8%) and only 6.1% of subjects in the control group had a CRP concentration greater than 5 mg / L (p <0.01). Conclusion. A significantly higher frequency of elevated serum CRP concentrations in individuals with MS, compared to those without MS, indicates both the importance of inflammation in the pathogenesis of MS and CRP being biomarkers and mediators of chronic inflammation.
The importance of coordination for the performance of falling techniques envisaged in the special physical education program
Authors: Paspalj Darko , Gužvica Milan , Vulin Lazar , Vojvodić Milenko
Published: February 2022

This paper examines the relationship between general coordination ability and the acquisition of falling techniques envisaged in the Special Physical Education program on a sample of 84 second-year male students aged 19 ± 0.6 years at the Faculty of Security Studies. The aim of this study was to determine the influence of general coordination on the efficiency of performing falling techniques and to define quantitative differences regarding motor coordination between the students who received poor grades and those who received better grades. The sample of variables consisted of thirteen tests to assess general coordination ability and variables to assess the level of the falling techniques acquired. The results of regression analysis showed that motor coordination is important for performing falling techniques envisaged in the Special Physical Education program, while, based on the results of the Mann-Whitney U test, a statistically significant difference in coordination between the students with law and high test scores was found in three variables: cushioning the ball (MKAAML), air agility (MKTOZ) and striking horizontal pads (MKRPLH) in favor of the students with high test scores. The results obtained could con-tribute to the economy of learning through better organization of the teaching process and the selection of a battery of tests to test motor skills during the student selection process for admission to the Faculty of Security Studies.
Regulations and deficiencies regarding the training of the protection and rescue units in Bosnia and Herzegovina
Authors: Jurišić Dragiša
Published: February 2022

The fact that the population, both in Bosnia and Herzegovina (BiH) and across the world, has been growingly affected by natural and other hazards indicates the need to develop a protection and rescue system. Although the existing system is legally defined and regulated, its actual functionality in the field, especially the training process, is questionable. This paper seeks to demonstrate the shortcomings of training within the protection and rescue system in BiH by analyzing legal solutions and other acts which should regulate training in the protection and rescue system at all levels. The analysis demonstrated that training is not implemented to a sufficient extent and a number of problems regarding the implementation of training, especially at the level of local governments which operate as first responders in the event of natural and other hazards.
Assessment of post extraction complications in Indians
Authors: Saravanan Keerthika
Published: February 2022

Extraction is one of the commonest procedures in dentistry. Therefore, it is of interest to evaluate the post extraction complications in patients undergoing extractions of permanent teeth. A total of 70 adult patients who had undergone dental extractions and presented with post -operative complications were included in the study and evaluated. Data collected was statistically analyzed using SPSS software and results obtained. Most of the patients with post extraction complications were in the age group of 31-40 years (21.6%), followed by 21-30 (20.2%) and 61-70 years (20.2%). Dry socket (39.19%) was the common post extraction complication in our study especially in the age group of 31-40 years. There was a statistically significant association between age of the patients and the post extraction complications (p<0.001). In our study, post extraction complications were commonly observed in age group of 31-40 years with a predilection for males. Dry socket was the most common post extraction complication. Age of the patient has a significant effect on post extraction complications. However, gender, smoking habits and systemic diseases have no influence on post extraction complications.
Intimate Partnership Formation and Intergenerational Relationships among Ethnic Minority Youth in Denmark
Authors: Singla Rashmi
Published: February 2022

This article is based on a research project drawing upon in-depth qualitative interviews (N=61) and data from a survey (N=628) of young people and parents belonging to the five largest ethnic minority groups in Denmark. The theoretical framework combines conceptualisations about conflict and the family with theories about modernisation/individualisation and discrimination effects. The dominating tendencies in the inter-generational relationships between young people and their parents on the subject of the young people’s intimate partnership formation are analysed and discussed. The ethic minority youth and parents’ reflections on the ethnic majority partnership formation patterns are delineated. The analyses indicate that relationships between young people and parents on the issue of intimate partnership formation can be cooperative or in opposition. This is contrary to the widespread discourse about serious conflicts between generations. Thus the article criticises the reductionistic conception of partnership formation being a question of either-or processes, i.e. own choice or parental choice, and appeals for broad concepts which include both-and processes, i.e. own choice and parental accept.
Human Development as semiotic-material Ordering: Sketching a Relational Developmental Psychology?
Authors: Kontopodis Michalis
Published: February 2022

The paper presented here is an attempt at casting human development as a semiotic-material phenomenon which reflects power relations and includes uncertainty. On the ground of post-structuralist approaches, development is considered here as a performative concept, which does not represent but creates realities. Emphasis is put on the notions of ‘mediation’, ‘translation’ and ‘materiality’ in everyday practices of students and teachers in a concrete school setting, where I conducted ethnographical research for one school year. The analysis of discursive research material of teachers’ discussions and interviews with students proves the developmental discourse to be interrelated to teachers’ and students’ positioning in the school; the developmental discourse orders ongoing interaction and enables students and teachers to perform the past and witness the future in a way which corresponds with dominant values and state social/educational policies. By translating a variety of events into a line moving from the past to the future as well as by materializing this line as diagrams and other semiotic-material objects, development becomes a technology of the self of (late) modernity which implies power relations and supports the maintenance of the modern order. On these grounds, a relational approach to development is suggested, which raises methodological and political issues.
Multiomic characterization of pancreatic cancer-associated macrophage polarization reveals deregulated metabolic programs driven by the GM-CSF–PI3K pathway
Authors: Boyer Seth , Lee Ho-Joon , Steele Nina , Zhang Li , Sajjakulnukit Peter , Andren Anthony , Ward Matthew H , Singh Rima , Basrur Venkatesha , Zhang Yaqing , Nesvizhskii Alexey I , Pasca di Magliano Marina , Halbrook Christopher J , Lyssiotis Costas A
Published: February 2022

The pancreatic ductal adenocarcinoma microenvironment is composed of a variety of cell types and marked by extensive fibrosis and inflammation. Tumor-associated macrophages (TAMs) are abundant, and they are important mediators of disease progression and invasion. TAMs are polarized in situ to a tumor promoting and immunosuppressive phenotype via cytokine signaling and metabolic crosstalk from malignant epithelial cells and other components of the tumor microenvironment. However, the specific distinguishing features and functions of TAMs remain poorly defined. Here, we generated tumor-educated macrophages (TEMs) in vitro and performed detailed, multiomic characterization (i.e., transcriptomics, proteomics, metabolomics). Our results reveal unique genetic and metabolic signatures of TEMs, the veracity of which were queried against our in-house single-cell RNA sequencing dataset of human pancreatic tumors. This analysis identified expression of novel, metabolic TEM markers in human pancreatic TAMs, including ARG1, ACLY, and TXNIP. We then utilized our TEM model system to study the role of mutant Kras signaling in cancer cells on TEM polarization. This revealed an important role for granulocyte–macrophage colony-stimulating factor (GM-CSF) and lactate on TEM polarization, molecules released from cancer cells in a mutant Kras-dependent manner. Lastly, we demonstrate that GM-CSF dysregulates TEM gene expression and metabolism through PI3K–AKT pathway signaling. Collectively, our results define new markers and programs to classify pancreatic TAMs, how these are engaged by cancer cells, and the precise signaling pathways mediating polarization.
Cardiovascular and Metabolic Adverse Reactions Associated with the Use of Antipsychotic Drugs: A Narrative Review
Authors: Patel Priya C , Navik Preeti L , Barvaliya Manish J , Patel Tejas K , Virani Hemangi A
Published: February 2022

The adverse drug reaction profile of antipsychotic drugs includes neurological, endocrinal anticholinergic and cardiovascular effects. The profile of each cardiovascular adverse effects, specific for each antipsychotic medication includes QT prolongation, orthostatic hypotension, myocarditis and metabolic effects, it also reduce the life expectancy of schizophrenic patients. There is a major clinical concern for the patients on long term therapy. This narrative review is focused on the cardiovascular profile of antipsychotic medications. The detailed aetiology, mechanism, monitoring and management of cardiovascular adverse effects are discussed in this review.
Effect of Perioperative Music Therapy/Medicine on Postoperative Pain in Women Undergoing Elective Lower Segment Caesarean Section Delivery under Spinal Anaesthesia: A Case-control Study
Authors: Halder Abhishek , Kumar Ashok , Hariharan Uma , Manjhi Bangali
Published: February 2022

Introduction: Women undergoing elective Lower Segment Caesarean Section (LSCS) delivery under spinal anaesthesia usually experience anxiety and stress due to unpleasant operative environment. Music therapy/music medicine has been found to relieve anxiety and stress besides decreasing pain and stable cardiorespiratory parameters. Aim: To assess the effect of perioperative music therapy/music medicine on pain and cardio respiratory parameters in women undergoing elective LSCS under spinal anaesthesia. Materials and Methods: The present study was case-control study in which 60 consecutive parturient women, planned for elective LSCS delivery under spinal anaesthesia, were randomly divided into music and non music groups of 30 each. Demographic characteristics of women were recorded. The ‘music group’ received preselected music three times for 20 minutes each along with standardised analgesia protocol. The ‘non music group’ received standardised analgesia protocol only. Respiratory and haemodynamic parameters were assessed during perioperative period. Postoperative pain was assessed using Visual Analogue Scale (VAS) scores in addition to comparisons of time for rescue analgesia between study and control groups. Statistical differences were derived using Mann-Whitney U-test. Results: Demographic characteristics of women were statistically insignificant. Significant differences were observed in Heart Rate (HR) at 30, 45 and 60 minutes Postanaesthesia Care Unit (PACU) (p-value 0.0278, 0.0151 and 0.02852, respectively) and Respiratory Rate (RR) at 60 minutes PACU (p-value 0.04884). This study found beneficial effect of music on pain as assessed by VAS in the postoperative period. Beneficial effect of music on pain observed in study group vs. controls at 1 hour (0.64 vs. 1.51), 2 hours (1.88 vs. 2.76) and 3 hours (3.07 vs. 3.47) of PACU stay (p-value 0.0003, 0.00152 and 0.02444, respectively). The study also detected a significant delay (29 minutes) in time for first rescue analgesia in music group (p-value 0.01732). Conclusion: Music therapy/medicine during elective LSCS delivery is beneficial on HR, respiratory rate, VAS and time to rescue analgesia.
Estimation of Ferritin and D-Dimer levels in COVID-19 Patients with Mucormycosis: A Cross-sectional Study
Authors: Yesupatham Susanna Theophilus , Mohiyuddin SM Azeem , Arokiyaswamy Sagayaraj , Brindha HS , Anirudh PB
Published: February 2022

ntroduction: There are increasing reports of the occurrence of fungal co-infections in Coronavirus disease-2019 (COVID- 19) patients resulting in severe morbidity among predisposed individuals. Mucormycosis is an Invasive Fungal Infection (IFI). Early anticipation and identification of fungal co-infections can significantly reduce morbidity rate among COVID-19 infected patients. Aim: To determine quantitatively the levels of ferritin and D-dimer in COVID-19 infected patients with mucormycosis. Materials and Methods: This cross-sectional study was conducted on 84 Real Time Polymerase Chain Reaction (RT- PCR) positive for COVID-19 in oropharyngeal swab patients from June 2021 to August 2021 at Sri Devaraj Urs Medical College, Kolar, Karnataka, India. D-dimer and ferritin levels were measured in the patient’s blood sample using Latex Enhanced Immunoturbidimetric method in Vitros 5.1 FS and Vitros Eci Immunodiagnostics, respectively. Continuous data represented as mean and standard error of mean, Kruskal-Wallis test and Mann-Whitney U test was used to test significance, p-value <0.05 was considered as statistically significant. Results: Of the 84 COVID-19 Infected patients, 40 were included in group 1, 25 patients in group 2 and 19 patients in group 3. A total of 21 patients were aged between 20-40 years, 48 patients between 41-60 years age group and 15 patients were in 61- 80 years of age group. The number of male patients was 63 and female patients were 21. The D-dimer levels were 1259.37±258.9, 2632.60±472.6 and 229.53±18.4 (p-value <0.001) in group 1, 2 and 3, respectively and ferritin levels were 528.58±45.03, 511.48±74.4, and 256.89±51.8 (p-value <0.007) in group 1, 2 and 3, respectively. Conclusion: Serum ferritin and plasma D-dimer were significantly elevated in COVID-19 patients with mucormycosis. Mucormycosis in COVID-19 patients without pre-existing co-morbidities may be attributed to the use of steroid therapy in these patients for COVID-19 infection. Thus, serum ferritin and plasma dimer levels may have a significant predictive role in the risk assessment for the development of mucormycosis among COVID-19 infected patients.
Productivity of Groundnut as Influenced by Integrated Use of Lime, Organics, Inorganic Fertilizers, and Biofertilizers in Acidic Soil of Tripura
Authors: Dey D. , Kundu M. C. , Sen D.
Published: February 2022

A field experiment was carried out on acidic soil of Khowai district of Tripura during 2017 and 2018 to study the effect of application of various combinations of lime, farmyard manure (FYM), poultry manure (PM), and rhizobium with the recommended doses of NPK on groundnut (Arachis hypogaea L.) productivity. The experiment was conducted in a completely randomized block design with 13 treatments; each replicated thrice. The application of the recommended dose of NPK @ 20:60:40 kg ha-1 along with lime @ 1/5th Lime Requirement (LR), PM @ 5 t ha-1 and seed treatment with Rhizobium @ 20 g kg-1 of seed significantly increased the seed yield and recorded the highest Benefit : Cost ratio (B:C) compared to the recommended dose of NPK alone as well as other treatments combinations. Thus, in achieving higher groundnut productivity with better return in acidic soils of Tripura, integrated use of inorganic fertilizers (NPK @ 20:60:40 kg ha-1) combined with lime @ 1/5th LR, PM @ 5 t ha-1, and seed treatment with Rhizobium @ 20 g kg-1 of seed might be recommended.
New Explanation for the Near-Side/Far-Side Lunar Maria Disparity
Authors: Herndon J. Marvin
Published: February 2022

Any attempt to understand the origin of lunar maria must as well account for the dearth of maria on the far-side of the Moon. Various attempts have been made to explain the origin of lunar maria based solely upon obvious lunar processes, namely, volcanism and impact phenomena. Here I posit a different explanation for the origin of lunar maria by analogy with observations of Earth, specifically related to its central nuclear fission georeactor. Georeactor formation is a natural consequence of density layering in oxygen-starved (highly-reduced) planetary matter and is ideally suited for magnetic field generation in planets and large moons. A portion of georeactor produced heat is channeled to Earth’s surface hot-spots, e.g., Hawaii and Iceland, where its georeactor origin is indicated by the high relative 3He/4He ratios observed and seismically imaged heat channels extending to the top of the core. Massive basalt floods, e.g., Siberian and Deccan Traps were driven by georeactor-produced heat as indicated by the high relative 3He/4He ratios of their occluded helium. These terrestrial basalt floods suggest to me that the lunar maria might have similar origins driven by the Moon’s nuclear fission “lunar-reactor.” Remanent magnetization of some lunar surface material is indicative of an ancient internally-generated magnetic field. That implication is consistent with the magnetic fields produced by central nuclear fission reactors in many planets and large moons. The location of the lunar-reactor at the Moon’s center of mass, displaced 2 km toward the Earth-facing side, in concert with Earth’s tidal pull, I posit, is principally responsible for driving the maria-basalt floods toward the Earth facing side of the Moon. In principle, it should be possible to verify the correctness of this concept by measuring the helium isotopes of maria basalt samples taken from depths sufficient to be unaffected by solar wind implanted helium.
A Rare Site of Presentation of B Cell Lymphoblastic Lymphoma
Authors: Jaishankar Jaistri , Senthilkumar K. , Anantharamakrishnan R. , Megha .
Published: February 2022

Lymphoblastic lymphoma is seen accounting to about 2% of all the lymphomas and it is a neoplasm of precursor B cells. Lymphoblastic lymphoma is highly aggressive, but is now  frequently curable with recent therapy. Lymphoblastic lymphoma is associated with radiation exposure and also exposure to pesticide. The lymphoblasts infiltrate nodal or extranodal structures and is commonly associated with large mediastinal masses with a high chances for spreading to bone marrow and the central nervous system. The prognosis in all age groups has drastically improved with the use of intensive ALL-type chemotherapy regimes, with a disease-free survival of 73-90% in children and 45-72% in adults.
A Cross-sectional Survey on Knowledge and Awareness of Dental Professionals Towards Medicolegal Issues in Teledentistry in Sharad Pawar Dental College
Authors: Morey Anumeha , Boradkar Vaibhavi , Rohankar Dimpal , Date Avanti , Chhabra Kumar Gaurav , Paul Priyanka , Reche Amit
Published: February 2022

Background: Many dental professionals are not familiar with medicolegal issues in teledentistry. Through our survey, many dental professionals will be aware of medicolegal issues in teledentistry. 

Objectives: To evaluate the knowledge and awareness regarding medicolegal issues in teledentistry among dental staff and postgraduates and assess the correlation of demographic information with knowledge and awareness regarding medicolegal issues in teledentistry among dental staff and postgraduates.

Methodology: The dental professionals and postgraduates of Sharad Pawar Dental College will be chosen.

Expected Results: Evaluating the knowledge and awareness of medicolegal issues in teledentistry among dental students. A more significant number of dental professionals are not familiar with medicolegal issues in teledentistry.

Conclusion: It is beneficial in long-distance clinical training and preserving with education, screening, and dentist laboratory communication. In rural regions in which there may be a scarcity of specialists, loss of complete and complicated health care teledentistry can amplify care to remote patient populations at an affordable value as well as ease the hassle of a scarcity of specialized dental consultants, with few drawbacks and steady efforts to fight them, teledentistry has promising future and an extended manner to go.
Diagnosis of Genital Tuberculosis by Cartrdige Based Nucleic Acid Amplification Test in Subfertile Women of Rural Hospital
Authors: Deo Asawari , Shrivastava Deepti , Shekhawat Harsha , Shelke Uttara
Published: February 2022

Tuberculosis has serious extra-pulmonary manifestations that are sometimes difficult to diagnose and thus left untreated. One such manifestation is female - genital tuberculosis (FGTB). Any diagnostic test is not efficient enough to prove the evidence of female genital tuberculosis. High level of clinical examination, detailed history of the patient, systemic examination, a series of tests to document M. tuberculosis as well as imaging techniques for characteristic structural changes are essential for the diagnosis.

There exists lot of diagnostic dilemmas for genital tuberculosis in the available literature.no single test is found confirmatory except for wet culture and histopathological positivity, which may become paucibacillary extrapulmonary sites and time consuming, which creates a need for an investigation which can provide quicker and accurate results. cartridge based nucleic acid amplification test [CBNAAT] being a molecular test may be rapid and promising to diagnose these lesions.

The diagnostic value of CBNAAT in detection of female genital tuberculosis seems to be limited, although it has a high positive predictive value.
Carving the Niche for Implant Placement in Narrow Alveolar Ridges: A Case Report
Authors: Sai Shruti , Ghadage Mahesh , Bedia Sumit , Joshi Mridula , Mahapatra Hrishikesh , Bedia Aarti
Published: February 2022

Insufficient width of the alveolar ridge often prevents ideal implant placement. Guided bone regeneration, bone grafting, alveolar ridge splitting and combinations of these techniques are used for the lateral augmentation of the alveolar ridge. Ridge splitting is a minimally invasive technique

indicated for alveolar ridges with adequate height, which enables immediate implant placement and eliminates morbidity and overall treatment time. The classical approach of the technique involves splitting the alveolar ridge into two parts with use of ostetomes and chisels. Modifications of this technique include the use of rotating instrument, screw spreaders, horizontal spreaders and ultrasonic device. The purpose of this article is to thoroughly describe all the different approaches in ridge splitting technique. Procedures in Dental implantology have witnessed significant advancement in the recent times. A plethora of options have opened these days owing to improved surgical techniques and wider criteria for patient selection. Ridge-expansion technique has gained immense popularity in patients with limited crestal bone width yielding improved outcomes. The procedure entails implant placement in narrow alveolar ridges following splitting and expanding the existing bone. This article illustrates this approach with a fascinating clinical case of insufficient mandibular alveolar ridge.
Subchorionic Haemaorrhage in First Trimester and Its Effects on Pregnancy Outcome
Authors: Deshmukh Snehal , Prasad Rashmi , Chakole Vivek
Published: February 2022

Background: Subchorionic haemorrhage which may or may not be associated with vaginal bleeding is definitely of concern as it predisposes to adverse pregnancy outcomes. This study is done with a aim to find how subchorionic haemorrhage affects pregnancy outcome.

Methodology: The study was carried out from January 2020 till July 2020. 57 antenatal women with singleton viable pregnancy from 6 weeks to 12 weeks gestation  having subchorionic haemorrhage on USG with or without bleeding were included in the study after informed consent. High risk pregnancies with any medical disorder were excluded. Size of Subchorionic haemorrhage was described as percentage involvement of gestational sac. Patient were closely followed for outcome as miscarriage, preterm delivery, abruption , intrauterine fetal death , IUGR or term delivery.

Conclusion: 52.63% of the patients were less than 30 years of age , 57.89% of the patients were primipara and 42.10 % were multipara. 24.56% of females had previous abortion, 14.03 %, suffered an abortion. Maximum 5 patients with miscarriage had large subchorionic haemarrhage  with  more than 50 % gestational sac. Intra uterine fetal demise occurred in only one patient with size of subchorionic haematoma between 26%-50%.  6 patients experienced preterm delivery before 37 weeks .Term delivery was seen in 42 patients and maximum 19 patients had SCH 11%-25% of Gsac. Though the outcome is variable , size of SCH definitely affects the outcome.
Protocol of Comparative Evaluation of Efficacy of Kulattha Gutika with Atorvastatin in the Management of Dyslipidemia (Medoroga)
Authors: Nandal Praveen , Wajpeyi Sadhana Misar
Published: February 2022

Introduction: The term 'Dyslipidemia' can be referred to Medoroga included under santarpanajanyavyadhi as per Ayurveda. In Dyslipidemia there is involvement of Tridosha with kaphadominance. Intake of unhealthy food, alcohol, cigarette smoking, stress and lack of physical activity are the main etiological factors of Dyslipidemia. According to Ayurveda Guru, Madhur, Sheet, Snigdha, Kapha Meda Vardhaka Ahar, Avyayam, Diwaswapa, Achinta and Bijadosha are the main causative factors for medoroga.

Aim and Objectives: Comprarative evaluation of Efficacy of Kulattha Gutika and Atoravastatin in the management of Dyslipidemia (Medoroga).

Material and Methods: Study contains 60 patients of Dyslipidemia which will be divided into two equal groups (each contains 30 patients). Group A (Interventional) patients will be treated with KulatthaGutika1 gm thrice a day after meal with warm water for 45 days and Group B (Experimental group) will be given Tab, Atorvastatin 10 mg at bedtime with warm water for 45 days. Objective parameters like BMI, Lipid profile and Fasting Blood Sugar will be assessed before and after treatment. Incidence of Dyslipidemia as per prakriti will be assessed by analysing prakriti of each patient.

Discussion: Kulttha is indicated for medoroga in Bhavprakash due to its kaphamedohar property which may help in improving objective parameters.

Result: Subjective and Objectives outcomes will be statistically analysed by appropriate method.

Conclusion: Conclusion will be drawn from result obtained.
A Review on Antiviral Activity of Favipiravir
Authors: Palathingal Mariya , Archana M. , Damodharan K. Athulya , Nuaman . , Ashisha P. , Marathakam Akash
Published: February 2022

The emerging severe acute respiratory syndrome coronavirus 2 pandemic endangers patients and physicians all over the world. The potency of COVID-19 antiviral drugs is still a matter of debate. The growing understanding of COVID-19 virology and clinical manifestations is resulting in a larger pool of potential pharmacological targets. Favipiravir is included in the treatment regimen of many countries, including some regions of India, that have recently updated their treatment standards and is expected to be an effective treatment for SARS-CoV-2 infection, as it can be used to treat many different types of RNA virus infections such as Ebola, influenza, and the foot-and-mouth disease virus can be treated with this new nucleoside analogue. This review describes the status, mechanisms, pharmacokinetics, and antiviral effect of Favipiravir.
A Triple‐Kill Strategy for Tumor Eradication Reinforced by Metal‐Phenolic Network Nanopumps
Authors: Sang Wei , Zhang Zhan , Wang Guohao , Xie Lisi , Li Jie , Li Wenxi , Tian Hao , Dai Yunlu
Published: February 2022

Stress response to radiation sensitizes immunologically nonresponsive tumors to cytotoxic T‐lymphocyte‐associated protein 4 (CTLA‐4) therapy. The combination of radiotherapy (RT) and CTLA‐4 immune checkpoint blockade therapy has been clinically adopted and has yielded outstanding cooperative effects from restricted local lethality to systemic immune response. However, this combination therapy induces resistance caused by T cell depletion and increased programmed death‐ligand 1 (PD‐L1) expression in tumor cells. Hence, suppressing PD‐L1 expression through RT coupled with anti‐CTLA‐4 therapy can directly and efficiently address tumor resistance. Herein, metal‐phenolic network is incorporated into a triple combination therapy. Hafnium, a radiosensitizer used in clinical studies, is coordinated with polyphenols to constitute the principal structure of nanopumps (AHSC NPs). AHSC NPs embedded with atovaquone and sabutoclax could alleviate hypoxia and accelerate the activation of the apoptosis signaling pathway. Clinical/preclinical materials and approaches are employed as foundations and innovatively incorporate AHSC NPs to furnish a research basis and reference value for the integration of nanotechnology into clinical trials.
Inhaled mRNA Nanoformulation with Biogenic Ribosomal Protein Reverses Established Pulmonary Fibrosis in a Bleomycin‐Induced Murine Model
Authors: Zhang Rui , Jing Weiqiang , Chen Chen , Zhang Shengchang , Abdalla Mohnad , Sun Peng , Wang Ganyu , You Wenjie , Yang Zhenmei , Zhang Jing , Tang Chunwei , Du Wei , Liu Ying , Li Xiaoxun , Liu Jitian , You Xiaona , Hu Huili , Cai Lei , Xu Fengbo , Dong Baixiang , Liu Minglu , Qiang Bangming , Sun Yanhua , Yu Gongchang , Wu Jibiao , Zhao Kun , Jiang Xinyi
Published: February 2022

Idiopathic pulmonary fibrosis (IPF), a lethal respiratory disease with few treatment options, occurs due to repetitive microinjuries to alveolar epithelial cells (AECs) and progresses with an overwhelming deposition of extracellular matrix (ECM), ultimately resulting in fibrotic scars and destroyed the alveolar architecture. Here, an inhaled ribosomal protein‐based mRNA nanoformulation is reported for clearing the intrapulmonary ECM and re‐epithelializing the disrupted alveolar epithelium, thereby reversing established fibrotic foci in IPF. The nanoformulation is sequentially assembled by a ribosomal protein‐condensed mRNA core, a bifunctional peptide‐modified corona and keratinocyte growth factor (KGF) with a PEGylated shielding shell. When inhaled via a nebulizer, the nanoformulations carried by microdrops are deposited in the alveoli, and penetrate into fibrotic foci, where the outer KGFs are detached after matrix metalloproteinase 2 (MMP2) triggering. The RGD motif‐grafted cores then expose and specifically target the integrin‐elevated cells for the intracellular delivery of mRNA. Notably, repeated inhalation of the nanoformulations accelerates the clearance of locoregional collagen by boosting the intralesional expression of MMP13 and alveolar re‐epithelialization mediated by KGFs, which synergistically ameliorates the lung function of a bleomycin‐induced murine model. Therefore, this work provides an alternative mRNA‐inhalation delivery strategy, which shows great potential for the treatment of IPF.
Automotive Holographic Head‐Up Displays
Authors: Skirnewskaja Jana , Wilkinson Timothy D.
Published: February 2022

Driver's access to information about navigation and vehicle data through in‐car displays and personal devices distract the driver from safe vehicle management. The discrepancy between road safety and infotainment must be addressed to develop safely operated modern vehicles. Head‐up displays (HUDs) aim to introduce a seamless uptake of visual information for the driver while securely operating a vehicle. HUDs projected on the windshield provide the driver with visual navigation and vehicle data within the comfort of the driver's personal eye box through a customizable extended display space. Windshield HUDs do not require the driver to shift the gaze away from the road to attain road information. This article presents a review of technological advances and future perspectives in holographic HUDs by analyzing the optoelectronics devices and the user experience of the driver. The review elucidates holographic displays and full augmented reality in 3D with depth perception when projecting the visual information on the road within the driver's gaze. Design factors, functionality, and the integration of personalized machine learning technologies into holographic HUDs are discussed. Application examples of the display technologies regarding road safety and security are presented. An outlook is provided to reflect on display trends and autonomous driving.
Interfacial Engineering for Highly Stable and Stretchable Electrodes Enabled by Printing/Writing Surface‐Embedded Silver and Its Selective Alloying with Liquid Metals
Authors: Liu Zelin , Chen Song , Zhang Guangyong , Shi Hang , Chen Xiaochan , Shi Wei , Liu Lan
Published: February 2022

Even though intrinsically stretchable liquid metals (LMs) have been widely used in the stretchable electrodes for improving the stretchability, it is still challenging to achieve stable interfaces in these electrodes. A usual approach of adhering the LMs on a substrate is to modify the LMs with an organic surfactant, which is easily ruptured under a dynamic deformation. Herein, a surface‐embedded silver and its selective alloying of LMs are reported to address this problem. Typically, the surface‐embedding structure and the alloying interaction are both robust and stretchable, enabling the high interfacial stability during deformation (the ability to resist peeling, scratching, and sonication). And the cracked silver layer under tensile strains can be well bridged by LMs, enabling the good conducting stability during deformation (resistance change of 0.076 at 50% strain, 0.18 at 100% strain, and 0.4 at 200% strain). It is noted that this interfacial engineering can be facilely organized by directly printing or writing, which is convenient for preparing customized electrodes and circuits. At last, a light‐emitting diode array and a drone remote controller are assembled using the stretchable electrodes, showing their advantages in practical application.
Using δ15N to screen for nitrogen fixation: Reference plant position and species
Authors: Cox Amanda , Boots‐Haupt Laura , Brasier Kyle , Riar Ranjit , Zakeri Hossein
Published: February 2022

The δ15N natural abundance technique is frequently used to quantify the proportion of legume nitrogen derived from atmospheric fixation (%Ndfa). This method compares the δ15N of a legume with a nonlegume reference plant to estimate the %Ndfa. For accurate estimations, it is recommended to pair each legume plot with a nonlegume reference plant to account for spatial variation. However, this pairing scheme is not feasible in large screening trials. Here, we tested the feasibility of eliminating reference plants to screen a faba bean (Vicia faba L.) population for %Ndfa. The first experiment screened 63 faba bean genotypes for %Ndfa by comparing estimates derived from an adjacent wheat (Triticum aestivum L.) reference plant in a nearest neighbor scheme (NN) with an arbitrary δ15N reference value (AR) of 7‰. Average and standard deviation of the genotypes’ %Ndfa were 58 ± 13% in 2019 and 72 ± 8% in 2020 using the NN model and 61 ± 11% in 2019 and 75 ± 7% in 2020 using the AR model. The AR model was able to identify a majority of the high and low %Ndfa genotypes in both years. In a second study, wheat and a dicot weed within the field were used as reference plants to estimate the %Ndfa. The weed reference plant resulted in 3 to 13% higher %Ndfa values compared with the wheat in three out of four testing environments, but the variation did not alter ranking of the genotypes for %Ndfa.
Promoting early management of frailty in the new normal: An updated software tool in addressing the need of virtual assessment of frailty at points of care
Authors: Sepehri Katayoun , Low Hilary , Hoang Jenny , Park Grace , Song Xiaowei
Published: February 2022

Introduction

Frailty is a state of diminished physiological reserve and can be assessed using the frailty index. Early management of frailty is crucial for preventing adverse outcomes. Intended for assessing home‐living older adults, the initial release of the eFI‐CGA software was prior to the coronavirus disease 2019 (COVID‐19) pandemic.

Methods

In addressing the increased need of virtual assessment, the eFI‐CGA was upgraded to version 3.0. In this paper, we introduce the updated electronic frailty assessment tool, reporting the newly developed features and validating its use.

Results

End‐user experiences with the previous versions are discussed. The updated features include a search function to resume disrupted assessments. The improved user interface enabled clinicians to record care management details.

Conclusion

This study represents an example of software solutions in moving from disruption to transformation, benefiting healthcare for older adults during this challenging time.
Small bowel bleeding treated successfully with transcatheter arterial embolization with imipenem/cilastatin
Authors: Arima Takahiro , Morimoto Kohei , Terai Kiyoshi , Kawamoto Ken , Muroya Ken , Koba Yuji , Omura Takashi
Published: February 2022

Background

Small bowel bleeding is an uncommon cause of lower gastrointestinal bleeding, which may require different management.

Case Presentation

A 37‐year‐old man presenting with hematochezia was promptly diagnosed with small bowel bleeding by computed tomography angiography. Transcatheter arterial embolization was carried out because the patient's hemodynamic status deteriorated. Hemostasis was achieved by embolization with imipenem/cilastatin, although superselective embolization failed. Capsule endoscopy revealed multiple ulcers and erosions. Drug‐induced small bowel injury was suspected to be the cause of small bowel bleeding.

Conclusion

Computed tomography angiography can facilitate the management of lower gastrointestinal bleeding. Considering transcatheter arterial embolization and choosing an optimal embolic agent depending on the situation are important in the management of hemodynamically unstable patients.