bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of Photoinitiator and Fluorescent Pigments Impact on Color Stability in Pigmented UV-Curable Coatings
Authors: Grigale-Soročina Zane , Birks Ingmārs , Vindedze Elina
Published: June 2021

The testing of thin colored coatings based on urethane acrylate composition is a technologically advanced, highly specialized and complex process. For decorative pigmented coatings color stability is crucial quality parameter. The photo chemically curable polymer films were prepared by addition of 3 different radical initiators (KTO, TPO, TPO-L) to aliphatic urethane acrylate composition with various pigments (solid and fluorescent). Coating color change were evaluated in UV chamber (with luminous intensity 130 mw spectrum λmax = 405 nm) after 1 h, 48 h and 72 h. Color measurements were performed according to the CIEL*a*b* color standard to evaluate their stability over time. It was found that pigmented coatings have higher risk of yellowness than clear coatings. Also fluorescent pigments containing red has tendency to yellow after UV light exposure. The influence of the photoinitiator on the color stability were inconsiderable.
Analysis of the Effects of Dynamic Alloying on the Structure of Aluminium and its Alloys
Authors: Usherenko Yulia , Mironov Viktor , Usherenko Sergey
Published: June 2021

The dynamic alloying of aluminum and its alloy with a high-speed stream of silicon carbide (SiC) particles simulates the effect of a stream of cosmic dust on spacecraft materials. The study showed a structure change in the volume of aluminum and its alloy and the formation of new structural elements. The transformation of the structure during dynamic alloying leads to a change of the composition and mechanical properties of the matrix material.
Pioglitazone Reverses Alcohol-Induced Alveolar Macrophage Phagocytic Dysfunction
Authors: Yeligar Samantha M , Mehta Ashish J , Harris Frank L , Brown Lou Ann S , Hart C Michael
Published: June 2021

Alcohol use disorders (AUD) increase susceptibility to respiratory infections by 2- to 4-fold in part because of impaired alveolar macrophage (AM) immune function. Alcohol causes AM oxidative stress, diminishing AM phagocytic capacity and clearance of microbes from the alveolar space. Alcohol increases AM NADPH oxidases (Noxes), primary sources of AM oxidative stress, and reduces peroxisome proliferator–activated receptor γ (PPARγ) expression, a critical regulator of AM immune function. To investigate the underlying mechanisms of these alcohol-induced AM derangements, we hypothesized that alcohol stimulates CCAAT/enhancer-binding protein β (C/EBPβ) to suppress Nox-related microRNAs (miRs), thereby enhancing AM Nox expression, oxidative stress, and phagocytic dysfunction. Furthermore, we postulated that pharmacologic PPARγ activation with pioglitazone would inhibit C/EBPβ and attenuate alcohol-induced AM dysfunction. AM isolated from human AUD subjects or otherwise healthy control subjects were examined. Compared with control AM, alcohol activated AM C/EBPβ, decreased Nox1-related miR-1264 and Nox2-related miR-107, and increased Nox1, Nox2, and Nox4 expression and activity. These alcohol-induced AM derangements were abrogated by inhibition of C/EBPβ, overexpression of miR-1264 or miR-107, or pioglitazone treatment. These findings define novel molecular mechanisms of alcohol-induced AM dysfunction mediated by C/EBPβ and Nox-related miRs that are amenable to therapeutic targeting with PPARγ ligands. These results demonstrate that PPARγ ligands provide a novel and rapidly translatable strategy to mitigate susceptibility to respiratory infections and related morbidity in individuals with AUD.
Altered IgA Response to Gut Bacteria Is Associated with Childhood Asthma in Peru
Authors: Hsieh Chyi-Song , Rengarajan Sunaina , Kau Andrew , Tarazona-Meza Carla , Nicholson Andrew , Checkley William , Romero Karina , Hansel Nadia N
Published: June 2021

Alterations in gut microbiota in early life have been associated with the development of asthma; however, the role of gut bacteria or the IgA response to gut bacteria in school-aged children with asthma is unclear. To address this question, we profiled the microbial populations in fecal and nasal swab samples by 16S rRNA sequencing from 40 asthma and 40 control children aged 9–17 y from Peru. Clinical history and laboratory evaluation of asthma and allergy were obtained. Fecal samples were analyzed by flow cytometry and sorted into IgA+ and IgA− subsets for 16S rRNA sequencing. We found that the fecal or nasal microbial 16S rRNA diversity and frequency of IgA+ fecal bacteria did not differ between children with or without asthma. However, the α diversity of fecal IgA+ bacteria was decreased in asthma compared with control. Machine learning analysis of fecal bacterial IgA-enrichment data revealed loss of IgA binding to the Blautia, Ruminococcus, and Lachnospiraceae taxa in children with asthma compared with controls. In addition, this loss of IgA binding was associated with worse asthma control (Asthma Control Test) and increased odds of severe as opposed to mild to moderate asthma. Thus, despite little to no change in the microbiota, children with asthma exhibit an altered host IgA response to gut bacteria compared with control participants. Notably, the signature of altered IgA responses is loss of IgA binding, in particular to members of Clostridia spp., which is associated with greater severity of asthma.
HLA-DR Marks Recently Divided Antigen-Specific Effector CD4 T Cells in Active Tuberculosis Patients
Authors: Tippalagama Rashmi , Singhania Akul , Dubelko Paige , Lindestam Arlehamn Cecilia S , Crinklaw Austin , Pomaznoy Mikhail , Seumois Gregory , deSilva Aruna D , Premawansa Sunil , Vidanagama Dhammika , Gunasena Bandu , Goonawardhana N D Suraj , Ariyaratne Dinuka , Scriba Thomas J , Gilman Robert H , Saito Mayuko , Taplitz Randy , Vijayanand Pandurangan , Sette Alessandro , Peters Bjoern , Burel Julie G
Published: June 2021

Upon Ag encounter, T cells can rapidly divide and form an effector population, which plays an important role in fighting acute infections. In humans, little is known about the molecular markers that distinguish such effector cells from other T cell populations. To address this, we investigated the molecular profile of T cells present in individuals with active tuberculosis (ATB), where we expect Ag encounter and expansion of effector cells to occur at higher frequency in contrast to Mycobacterium tuberculosis–sensitized healthy IGRA+ individuals. We found that the frequency of HLA-DR+ cells was increased in circulating CD4 T cells of ATB patients, and was dominantly expressed in M. tuberculosis Ag–specific CD4 T cells. We tested and confirmed that HLA-DR is a marker of recently divided CD4 T cells upon M. tuberculosis Ag exposure using an in vitro model examining the response of resting memory T cells from healthy IGRA+ to Ags. Thus, HLA-DR marks a CD4 T cell population that can be directly detected ex vivo in human peripheral blood, whose frequency is increased during ATB disease and contains recently divided Ag-specific effector T cells. These findings will facilitate the monitoring and study of disease-specific effector T cell responses in the context of ATB and other infections.
Intellectual property protection for scholarly publishing in the Italian framework: a globally open approach for medical and life sciences authors
Authors: Bozzato Valentina , Gnoato Marianna , Vilia Antonia , Apostolico Mauro
Published: June 2021

This paper aims at analyzing the importance of protection of intellectual property (IP) in biomedical scholarly publications, both for the author’s reputation and the dissemination of scientific knowledge. The laws that regulate IP are very complex and differ from country to country. We shall focus on the Italian framework though many considerations could be applied to foreign contexts. IP is very articulated, yet often ignored, that is worth paying attention to a correct copyright management can help researchers promote their Work and the community to benefit from it. In the scholarly publishing field, there are two main areas: traditional publishers and open-access publishers. The first group requires a fee to access the content they publish and usually ask the authors for a complete transfer of copyright. The possibility to negotiate terms with such publishers is often overlooked: scholarly authors tend to think they do not have leverage in the publishing cycle. The so-called addendum and professional figures, like librarians and attorneys, can help manage the authors’ intellectual property. On the other hand, open-access publishers give free access to published material, guaranteeing the protection of IP: thanks to the Creative Commons Licenses, the authors do not have to surrender their copyright to the publisher and can manage and control the use made out of their Work. Applying the principles put forth in this article implies enhancing research dissemination by increasing its impact and visibility. However, to achieve such a goal, it is necessary to protect intellectual property for the sake of authors, users, and scientific progress.
Correlation of levator ani muscle strength measurement between Modified Oxford Grading Scale and perineometer on pelvic organ prolapse patient
Authors: Moegni Fernandi , Wengkang Ingrid Felicia Ocsilia
Published: June 2021

Pelvic Organ Prolapse (POP) is a debilitating condition affecting about half of all women aged of more than 60 years globally. Reduced levator ani muscle strength in POP is associated with worse symptoms and prognosis. Measurement of levator ani muscle strength can be done with several tools such as perineometer and digital palpation. However, there is currently no study regarding conformity between tests. The aim of this study is to determine the correlation between tests in POP patients. An analytic observational study using cross sectional design was done to determine conformity between perineometer and digital examination using Modified Oxford Grading Scale (MOS) in Dr Cipto Mangunkusumo National General Hospital, Indonesia during the period of July, 2018 to June, 2020. Correlation between tests was determined using Spearman test. Cut-off of perineometer reading for each MOS score was also determined. A total of 110 subjects examined with both perineometer and digital palpation were recruited to the study. Positive correlation was observed between perineometer reading and Modified Oxford Grading Scale (r = 0.790, p < 0.001). According to the result, values between 0.01 – 9.64 cmH2O correspond to very weak pressure (MOS 1); 9.65 – 22.49 cmH2O represent weak pressure (MOS 2); 22.5 – 35.24 cmH2O represent moderate pressure (MOS 3); ≥ 35.25 cmH2O represent good pressure (MOS 4). There was a strong correlation between MOS and perineometer result for measuring levator ani strength in POP patients.
2021 ISHNE/HRS/EHRA/APHRS Expert Collaborative Statement on mHealth in Arrhythmia Management
Authors: Varma Niraj , Cygankiewicz Iwona , Turakhia Mintu , Heidbuchel Hein , Hu Yufeng , Chen Lin Yee , Couderc Jean-Philippe , Cronin Edmond M. , Estep Jerry D. , Grieten Lars , Lane Deirdre A. , Mehra Reena , Page Alex , Passman Rod , Piccini Jonathan , Piotrowicz Ewa , Piotrowicz Ryszard , Platonov Pyotr G. , Ribeiro Antonio Luiz , Rich Robert E. , Russo Andrea M. , Slotwiner David , Steinberg Jonathan S. , Svennberg Emma
Published: June 2021

This collaborative statement from the International Society for Holter and Noninvasive Electrocardiology/Heart Rhythm Society (HRS)/European Heart Rhythm Association/Asia-Pacific HRS describes the current status of mobile health (mHealth) technologies in arrhythmia management. The range of digital medical tools and heart rhythm disorders that may be applied to and clinical decisions that may be enabled is discussed. The facilitation of comorbidity and lifestyle management (increasingly recognized to play a role in heart rhythm disorders) and patient self-management are novel aspects of mHealth. The promises of predictive analytics but also operational challenges in embedding mHealth into routine clinical care are explored.
A case series of donor tissue-transmitted keratitis and endophthalmitis following Descemet stripping automated endothelial keratoplasty
Authors: Mukhija Ritika , Jain Vatika , Yadav Saumya , Vanathi Murugesan , Tandon Radhika
Published: June 2021

Donor-transmitted infection is one of the most dreaded complications after cornea transplant. We report four cases of fulminant graft infection with endophthalmitis following descemet stripping automated endothelial keratoplasty (DSAEK); all of these resulted from donor contamination by multidrug-resistant gram-negative bacteria (Pseudomonas in two cases, Proteus and Enterobacter in the other two). All donor corneas were retrieved in hospital premises, either ward or mortuary suggesting a possible nosocomial origin of these microorganisms. All four patients required surgical intervention for control of infection and had dismal clinical outcomes. Furthermore, in three cases, mate cornea also showed similar contamination, and additional two of these recipients also developed graft infection indicating an infection rate as high as 86%. This case series highlights an important issue of fulminant nosocomial donor cornea-related infections, possible despite standard precautions, with emergence of multidrug-resistant virulent pathogens. Adequate training of eye bank and health-care personnel and ensuing stringent protocols for retrieval and storage of corneas may help in reducing such sight-threatening adverse reactions and also consequent further ramifications.
Hypotonous malignant glaucoma following glaucoma drainage device implantation
Authors: Kumar Suresh , Singla Ekta , Ichhpujani Parul , Rehman Obaidur
Published: June 2021

Malignant glaucoma also known as “aqueous misdirection” is a frightening complication post glaucoma surgery. The usual presentation is with high intraocular pressure with flat anterior chamber both centrally and peripherally. The management option includes pharmacotherapy, laser and pars plana vitrectomy(PPV). We describe a case of malignant glaucoma which presented one day after the surgery with low intraocular pressure. The patient was managed by anterior vitrectomy via paracentesis with anterior vitrectomy settings by glaucoma surgeon.
Can there be smoke without fire? Optical coherence tomography angiography has the answer
Authors: Vignesh Thoguluva P , Kohli Piyush , Kumar Jayant , Rosenfeld Philip J , Ramasamy Kim
Published: June 2021

Macular edema is typically seen on optical coherence tomography (OCT) as fluid-filled cystic alterations that cause increased retinal thickness. The increased OCT reflectivity within these intraretinal spaces in the outer avascular retina can exhibit flow-like properties when imaged using OCT angiography (OCTA). The motion signal arising from within these intraretinal cavities corresponds to a feature of exudation known as suspended scattering particles in motion (SSPiM). We present multimodal imaging of a patient with SSPiM who underwent partial resolution of this OCTA finding.
Recurrent central serous chorioretinopathy in a surgically closed traumatic macular hole
Authors: Soman Manoj , Sheera K R , Nair Unnikrishnan
Published: June 2021

A 36-year-old gentleman with history of central serous chorioretinopathy (CSCR) developed full thickness macular hole in the right eye with recurrence of CSCR 2 weeks after blunt trauma to his right eye. Vitrectomy resulted in complete closure of the macular hole and resolution of the subretinal fluid. Post macular hole surgery he developed two episodes of CSCR recurrence with no reopening of the hole. This report hypothesises the possible mechanisms underlying this unusual association and explains how a surgically manipulated macular tissue could endure significant submacular fluid accumulation.
Dangerous and deadly phenytoin-induced idiosyncratic mydriatic reaction in an epileptic patient precipitating a bilateral acute angle-closure attack
Authors: Ramesh Prasanna Venkatesh , Ramesh Shruthy Vaishali , Rajasekaran Ramesh , Ramesh Meena Kumari
Published: June 2021

A 52-year-old woman presented with acute bilateral ocular pain, headache and vomiting. Examination revealed bilateral circum-corneal congestion, 360° closed angles with a shallow chamber and sluggish mid-dilated pupil. Intraocular pressure was 40 and 42 mm Hg in OD and OS respectively. On vigilant history taking, patient revealed administration of Phenytoin for her epileptic event recently. The suspected drug was stopped and the symptoms reversed. YAG PI was performed, visual acuity improved to 20/20 with reduction of intraocular pressures to normal. This case highlights the risk of developing bilateral acute angle-closure attack after Phenytoin administration.
Botulinum toxin
Authors: Ganesh Sandra C , Srushti D S , Narendran Kalpana
Published: June 2021

Cyclic esotropia is associated with alternating periods of esotropia and orthotropia within a defined cycle, occurring typically in pre-school children. Therapeutic options include surgery which is based on strabismic day angle, or injection of botulinum toxin into the medial rectus muscle. The latter is a simpler, less invasive, and potentially surgery sparing option causing a temporary drug-induced muscle paresis and providing enough opportunity to regain the fusion potential. We report one such case of childhood cyclic esotropia treated with injection botulinum toxin.
Postoperative endophthalmitis by Scedosporium apiospermum – A case report
Authors: Agarwal Manisha , Garg Ankit , Pegu Julie , Singh Shalini , Shah Shalin , Gandhi Arpan
Published: June 2021

A male patient underwent an uneventful cataract surgery. He developed fungal postoperative endophthalmitis by Scedosporium apiospermum species. This fungus is a common cause of endogenous endophthalmitis in immunocompromised patients with poor visual outcomes. We report this case to share our experience of managing fulminant postoperative endophthalmitis with an iris fungal ball in an immunocompetent patient caused by S. apiospermum.
New-onset anterior uveitis in two patients on ustekinumab for inflammatory bowel disease
Authors: Fridman Gabrielle , LaMattina Kara C
Published: June 2021

This report presents the first published cases of new-onset uveitis in patients on ustekinumab therapy. We present two patients with inflammatory bowel disease who developed anterior uveitis while on ustekinumab 90 mg every 8 weeks. Both patients achieved quiescence of their uveitis and improved control of their systemic disease with increased dose frequency of ustekinumab at every 4 weeks. Further investigation is warranted to determine if a true association exists.
Intravitreal triamcinolone in the treatment of serous retinal detachment secondary to choroidal osteoma without choroidal neovascularization
Authors: Chiu Fang-Yi , Chen Lee-Jen , Chan Wei-Chun , Tsai Shawn
Published: June 2021

Choroidal osteoma (CO) is a rare, benign, ossifying tumor of the choroid usually seen in otherwise healthy eyes. Vision impairment in CO is mainly attributed to serous retinal detachment (SRD) with or without choroidal neovascularization (CNV) and subfoveal tumor decalcification. We report a 54-year-old man with CO-related SRD without concomitant CNV in his right eye. The subretinal fluid was refractory to intravitreal aflibercept injections. Intravitreal injections of triamcinolone acetonide (IVTA) were performed and resulted in significant fluid resolution and remarkable visual improvement. This is the first reported case in the literature demonstrating the efficacy of IVTA in CO-related SRD.
Growth retardation-alopecia-pseudoanodontia-optic atrophy (GAPO) syndrome
Authors: Sethi Aditya , Sethi Sahebaan S
Published: June 2021

This case reports on a 21/2-year-old male child with GAPO syndrome, a rare autosomal recessive condition characterized by growth retardation (G), alopecia (A), pseudoanodontia (P), and optic atrophy (O). Since Anderson and Pindborg in 1947 first described this syndrome, close to 30 individuals have been reported with this diagnosis. Often a history of consanguinity is noted, as in our case, in this rare autosomal recessive condition. The phenotype of this condition, initially thought to be a result of ectodermal dysplasia, can be attributed to the accumulation of extracellular connective tissue matrix and its progressive character must be pointed out. The clinical findings, ophthalmological features that include optic atrophy, glaucoma, are reviewed and discussed.
Crosslinking as a treatment option for lipid keratopathy
Authors: Santiago Esteban
Published: June 2021

The purpose of this case report was to present a case of a patient treated with corneal collagen crosslinking for keratoconus with the secondary benefit of improvement of an established lipid keratopathy. After one session of crosslinking in both eyes, a marked regression of the lipid keratopathy in OS was observed in the 9th month follow-up visit. To the best of our knowledge, this is the first case report of lipid keratopathy improvement with crosslinking treatment. This can be another option when treating this condition in order to prevent visual loss and more invasive treatments.
Bilateral buphthalmos associated with neonatal-onset ectropion uveae, microspherophakia and pigment dispersion
Authors: Senthilkumar Vijayalakshmi A , Krishnadas R , Ravichandar A
Published: June 2021

Childhood glaucoma is a potentially blinding disease and poses crucial challenges in both diagnosis and management. We report a rare case of secondary glaucoma associated with nonacquired ocular anomalies in a 3-month infant with a family history of pigmentary glaucoma (PG) in two generations presenting as bilateral buphthalmos associated with ectropion uveae, microspherophakia, and high myopia. The child was successfully managed by combined trabeculotomy and MMC-augmented trabeculectomy with stabilized IOP at 12 months follow-up.
Screening for colorectal cancer in Nigeria
Authors: Okonkwo Uchenna , Onyekwere Charles
Published: June 2021

Background:

Colorectal cancer (CRC) is common in Africa including Nigeria contrary to popular opinion. Screening for CRC is cost-effective and reduces morbidity and mortality.

Aim:

The aim of the study was to assess the practice of CRC screening among gastroenterology practitioners in Nigeria.

Methods:

This was a questionnaire-based cross-sectional descriptive study conducted among gastroenterology practitioners attending their annual conference in 2016. Data were analyzed using SPSS version 20.

Results:

A total of 65 respondents completed the questionnaire. The mean age was 37.68 years. Majority (95%) of the respondents practised in tertiary hospitals. Screening for CRC was practised by 54% of the respondents, with colonoscopy and guaiac fecal occult blood test being the preferred screening modalities. Indications for screening were mostly symptom based with varied protocols and outcomes.

Conclusion:

The practice of CRC screening among gastroenterology practitioners in Nigeria is variable. There is a need to formulate national guidelines and colonoscopy quality control tools to improve awareness and standardize practice.
An Investigation of Occupational Therapy Utilizing Sensory Modulation to Manage Co-Morbid Chronic Pain and Substance Use in Order to Promote Occupational Performance and Recovery
Authors:   , Ruth Claire
Published: June 2021

Background: Those with chronic pain have worse drug and alcohol treatment outcomes and higher rates of relapse compared to those without pain or with reduced pain (Ilgen et al., 2020). Methods: A descriptive study was employed with the aim of determining what are the sensory processing pattens of those with co-morbid chronic pain and in recovery for substance use. All participants completed the Adolescent and Adult Sensory Profile, the Brief Pain Inventory, and the Personal Recovery Outcome Measure (PROM). Results: From the preliminary findings, individuals with co-morbid chronic pain and substance use may have atypical sensory processing in areas of sensation sensitive, sensation avoiding, and low registration, compared to the normative sample. Individuals within this clinical setting in general were not receiving non-pharmacological treatment for their pain. With pain fluctuating between mild (2.2/10) and severe (6.0/10) throughout the day. Results of the PROM were an average of 21/30. Item 21 states “I can manage stress”. From these findings a 5-week sensory based OT Group was implemented at a PHP/IOP treatment center focusing on self-management, health-management, and stress reduction strategies to improve overall occupational performance. A pain management OT Group is also included in the manual. Conclusion: Individuals with co-morbid chronic pain and substance use may have sensory processing patterns that are impacting function and recovery. This highlights the potential value of further research and consideration in clinical practice of these unique patterns and how they may be impacting recovery and long-term sobriety.
Penggunaan Google Classroom dalam Diskusi Online
Authors: Joko Prayudha.S
Published: June 2021

Objektif. Adanya pandemi Covid 19 yang telah menyebar keseluruh dunia telah menghentikan banyak aktifitas manusia. Salah satu sektor yang paling berdampak atau terhenti ialah sektor pendidikan. Sekolah dan perguruan tinggi menutup akses mereka untuk diadakannya pendidikan secara tatap muka, sehingga menyebabkan beralihnya pengajaran tatap muka dengan menggunakan sistem virtual atau lebih dikenal dengan pembelajaran secara online atau daring. Pembelajaran secara online atau daring merupakan satu-satunya alternatif ditengah merebaknya virus mematikan tersebut, sehingga  menuntut guru maupun siswa untuk pandai dalam memanfaatkan teknologi dalam menunjang pendidikan. Pembelajaran online atau daring artinya harus siap memanfaatkan teknologi dan aplikasi yang mendukung pembelajaran secara online tersebut. Salah satu teknologi yang digunakan ialah menggunakan internet yang terhubung dengan komputer atau handphone dimana terdapat banyak aplikasi atau platform pembelajaran yang dapat digunakan. Salah satunya ialah menggunakan Google Classroom, aplikasi ini merupakan fitur belajar dari perusahaan besar Google yang sangat bermanfaat dalam belajar ditengah pandemi Covid 19 ini.  Oleh karena itu, penelitian ini bertujuan untuk mengetahui efektifitas dan persepsi siswa  terhadap Google Classroom dalam diskusi online.

Material and Metode. Metode yang digunakan dalam penelitian ini ialah kualitatif dengan menggunakan pendekatan deskriptif. Teknik sampling yang digunakan dalam penelitian ini ialah total sampling dengan mengamati percakapan belajar siswa selama menggunakan Google classroom kemudian kuisioner diberikan untuk mengetahui pendapat siswa terkait penggunaan Google Classroom dalam diskusi online. Kemudian data yang didapatkan di interpretasikan dan dijabarkan sesuai dengan kondisi nyata  yang ada.  

Hasil. Dalam diskusi online yang telah dilakukan menggunakan Google Classroom mengindikasikan bahwa partisipasi siswa dalam diskusi online selalu meningkat dan memberikan tanggapan saat berdiskusi. Selain itu juga hasil yang diberikan melalui kuisioner menunjukan penggunaan Google Classroom memberikan dampak positif dalam penggunaannya selama pembelajaran online atau daring akibat pandemi Covid 19.

Kesimpulan. Diskusi online dengan menggunakan Google Classroom memberikan cara baru dalam belajar ditengah pandemi Covid 19 ini. Pemanfaatan aplikasi ini sangat membantu dalam proses belajar mengajar terutama dalam berdiskusi secara online. Oleh karena itu, pengunaan Google Classroom sangat menunjang kegiatan diskusi online selama belajar secara online atau daring ditengah pandemi Covid 19.
PENGARUH PENERAPAN SISTEM E-FILLING TERHADAP KEPATUHAN WAJIB PAJAK ORANG PRIBADI PADA KPP PRATAMA SUMEDANG
Authors: Yadi Sukmayadi
Published: June 2021

Objektif. Secara umum pajak adalah iuran rakyat kepada kas negara berdasarkan undang-undang (sehingga dapat dipaksakan) dengan tiada mendapat balas jasa secara langsung individual. Pajak mempunyai dua fungsi penting dalam perekonomian suatu negara. Pertama pajak merupakan salah satu dana pemerintah untuk melakukan pembangunan, baik pemerintah pusat maupun pemerintah daerah. Kedua pajak berfungsi sebagai alat yang mengatur kebijakan-kebijakan pemerintah di bidang sosial ekonomi. Untuk mengoptimalkan pelayanan dan meningkatkan kesadaran serta keinginan masyarakat untuk tertib sebagai wajib pajak, dilakukan perbaikan proses bisnis yaitu dengan memanfaatkan teknologi informasi dan komunikasi dengan menerapkan sistem e-filling. Dan inti permasalahan dalam penelitian ini adalah tentang kepatuhan wajib pajak dalam melaporkan SPT nya melalui sistem online yaitu E-Filling. Penelitian ini bertujuan untuk mengetahui penerapan sistem e-filling, kepatuhan wajib pajak orang pribadi, dan untuk mengetahui besarnya pengaruh penerapan sistem e-filling terhadap kepatuhan wajib pajak orang pribadi pada KPP Pratama Sumedang

Material and Metode. Metode penelitian ini menggunakan deskriptif kuantitatif dengan pendekatan survey. Teknik pengambilan sampel menggunakan metode simple random sampling. Populasi penelitian ini wajib pajak orang pribadi yang terdaftar di KPP Pratama Sumedang. Sampel yang digunakan dalam penelitian ini sebanyak 100 responden. Datapenelitiandiperoleh melalui kuisioner dan observasi. Teknik analisa yang digunakan adalah uji koefisien korelasi, uji koefisien determiasi, analisi regresi sederhana, serta uji hipotesis.

 

Hasil. Hasil penelitian menunjukan bahwa terdapat korelasi yang kuat antara penerapan e-filling dengan kepatuhan wajib pajak orang pribadi dengan nilai koefisien korelasi sebesar 0,669. Koefisien determinasi sebesar 51,2% sisanya sebasar 48,8% dipengaruhi oleh variabel lain yang tidak dibahas dalam penelitian ini. Hasil analisis regresi sederhana dinyatakan dengan persamaan Y=13,801 + 0,534X dengan nilai
SISTEM PENDETEKSI KEMIRIPAN PADA PROPOSAL PENGAJUAN TUGAS AKHIR MENGGUNAKAN ALGORITMA RABIN-KARP
Authors: Asnawi Muhamad Fuat , Zaenal Abidin
Published: June 2021

Objektif. Mengambil atau menyalin karya orang lain lain adalah diperbolehkan asalkan menganut ketentuan yang berlaku. Tindakan pengambilan tulisan / ide jurnal untuk menemukan tema tugas akhir juga disarankan karena untuk pengembangan suatu penelitian. Pada pemeriksaan kemiripan pada dokumen pengajuan proposal tugas akhir ini, dimana penulis mengukur persentase kemiripan di antara satu dokumen dan dokumen lainnya yang ada di database. Material dan Metode. Dalam pembuatan Sistem Pendeteksi Kemiripan Pada Pengajuan Proposal Tugas Akhir Menggunakan Algoritma Rabin-Karp ini, penulis menggunakan alat bantu perancangan UML(unified modelling language) meliputi Use case, activity diagram, sequence diagram, class diagram dan ERD (Entity Relation Diagram) untuk perancangan database. Penulisan menggunakan bahasa pemrograman PHP dengan framework Codeigniter dan MySql sebagai perancangan database sistem. Dalam pengembangan aplikasi kami menggunakan Waterfall sebagai metode pengembangan sistem.Hasil. Sistem Pendeteksi Kemiripan Pada Pengajuan Proposal Tugas Akhir Menggunakan Algoritma Rabin-Karp Kesimpulan. Sistem ini dapat membantu bagi mahasiswa agar tidak melakukan tindakan plagiarisme atau menyalin sama persis pada dokumen pengajuan tugas akhir.
Understanding design as a messy socio-technical Actor-Network
Authors: Hasbun Yamil
Published: June 2021

Basándose en principios analíticos clave de la Teoría del Actor-Red y de los Estudios Sociales sobre Ciencia y Tecnología, el presente artículo presenta un estudio semiótico material sobre la agencia de entidades no humanas en la construcción performativa de nuevas realidades emergentes materializadas en la concepción creativa, la representación y la circulación de objetos comúnmente entendidos simplemente como ‘diseño’. Por tanto, su enfoque estará en reflexionar sobre la capacidad de los objetos materiales –modelos, bocetos, etc.– para activamente determinar el surgimiento de nuevas realidades creativas (diseños) que se dan a diario en nuestras aulas y talleres. Su intención es contribuir al creciente cuerpo de trabajo académico que busca equipar analíticamente a profesores e investigadores del diseño para la construcción de una teoría del diseño alternativa que sea capaz de entender el diseño como un asunto más que humano.
Se cimientan tres argumentos: Primero, que el proceso creativo de diseño es característicamente desordenado, contingente y no lineal, en lugar de la explicación ordenada, controlable y lineal que algunos libros de texto clave sobre la teoría y metodología del diseño han tendido a sugerido. Segundo, que el diseño debe entenderse como un proceso que irremediablemente se basa en un equilibrio entre la presencia de ciertas entidades materiales y la ausencia simultánea de otras; y, por último, que gran parte del desorden que caracteriza el proceso creativo de diseño es el resultado de las intrincadas dificultades que surgen en el proceso de negociaciones constantes entre actores ‘humanos’ y actores ‘no humanos’.
The design studio in promoting citizenship: an educational project developed in Aoteaora
Authors: Mortensen Marcos , Tavares Tatiana
Published: June 2021

This study describes the framework of a brief developed for level 7 of a Bachelor of Graphic Design majoring in Communication Design and the design outcomes developed during an academic semester in Aotearoa. The brief employed the Design Studio approach to integrating social, technical and cognitive dimensions of knowledge construction. We explored the potential of Social Design to engage students in real-world problem and design outcomes to improve local and global contexts and facing problems that are complex and with long-term effects. The study seats in the post-positivist paradigm, and privileges the pluralism between quantitative data, and the qualitative perspectives of historical, comparative, philosophical, and phenomenological analysis. It contributes to discussions about the design studio approach in Design Education and methodologies for the development of tertiary-level curricula.
Dinâmica de Uso da Terra em Senador José Porfírio – PA, Amazônia Oriental
Authors: Moura Valdinei Mendes , Marinho José Antônio Magalhães , Veloso Gabriel Alves
Published: July 2021

Na região de Integração do Xingu a dinâmica do uso e cobertura da terra perpassa por transformações aceleradas, consolidadas principalmente por redes de transportes rodoviárias, sobretudo a partir da década de 70, com a abertura da rodovia Transamazônica. Dessa forma, nesse artigo se priorizou analisar a dinâmica de uso e cobertura da terra no município de Senador José Porfírio, inserido em uma área de intensa mudança, principalmente após a instalação da Usina Hidroelétrica de Belo Monte. Nesse sentido, os procedimentos metodológicos utilizados centraram-se no levantamento de informações e dados em bases digitais, e na subsequente análise e interpretação do material obtido e pesquisa bibliográfica sobre a dinâmica dos usos da terra na região amazônica. O objetivo da pesquisa foi analisar a dinâmica de uso da terra no município de Senador José Porfírio, no período de 2010 a 2019, considerando os aspectos históricos e econômicos, assim como suas expressões socioambientais, paisagísticas e territoriais. Nos resultados e discussões constatou-se que as áreas de agricultura sofreram variações, com expansão do cultivo do cacau, além disso, contatou-se que a extração ilegal de madeira, e consequentemente o desmatamento para produção agropecuária vem avançando principalmente sobre as áreas de assentamentos e terras indígenas.
Gender-separate education in Spain: reflections on educational rights and freedoms from a constitutional and human-rights perspective
Authors: Martínez López-Sáez Mónica , Almenar Rodríguez Roser
Published: July 2021

Gender-separate education, understood as a pedagogical model that provides separate schooling for boys and girls, has been subject to legal and public scrutiny for the past thirty years. Nonetheless, it has not been until 2018 that this educational option was put into the spotlight, especially regarding its constitutionality and compatibility with arts. 1.1, 9.2 and 14 of the Spanish Constitution, which constitute a manifestation of the principles of equality and non-discrimination, while at the same time trying to balance it with art. 27 of said constitutional text, with respect to the right to education and freedom to choose and create educational centers. Against this backdrop, the present paper reviews the constitutional state of play and makes further reflections from a rights-based perspective and taking into account the cultural pluralism that characterizes contemporary societies.
The First Three Months of the COVID-19 Pandemic: The World Health Organization's Response
Authors: Güner Öner , Buzgan Turan
Published: June 2021

Abstract

Infectious diseases are generally preventable public health problems; however, they cause epidemics, economic losses, and deaths at all levels worldwide. Especially with the effect of globalization, it has been observed much better with the COVID-19 pandemic, where viral outbreaks can rapidly affect all stages of life. Experiences show that not only national authorities, but also international organizations should play critical roles in the control of infectious diseases. Based on this perspective, in our study, the responses of the World Health Organization (WHO), which has a decisive role in international health policies, to prevent the spread of the COVID-19 pandemic in the first three-month period were examined. In addition, the possible effects of the national measures and policies taken by Canada, Turkey, Pakistan, and Tajikistan, which are in different income groups according to the World Bank, on the number of cases and deaths were discussed. In this context, the contributions, or potential effects of the WHO on the performance of these countries against the COVID-19 were interpreted. It was understood that the countries in different income groups have developed policies based on their capability at country level independent from other countries in the fight against COVID-19 outbreak. It has been evaluated that the success of countries in the fight against the outbreaks is affected by different parameters such as average age of the country's populations, health infrastructures and income levels that greatly affect access to medical supplies and equipment. However, it can be said that international organizations with institutional power such as WHO cannot play a leading role at the expected level in the prevention of the pandemic and ineffective in directing local policies and ensuring international coordination. Especially in the COVID-19 viral pandemic environment where fast and precise decisions are required, this leading role is desperately needed. The first quarterly decisions and meeting notifications of the WHO in the COVID-19 pandemic were examined in our study and it was understood that these outcomes cannot provide a definite and effective management plan to national health policy makers, although WHO presented diagnostic tools rapidly and, in some degree maintained the supply chain of medical equipment globally. As a result, when all these elements determined in our study were considered together; the need for an integrative, proactive, and fair international health institution that produces prompt, effective and constantly updated comprehensive policies should be emphasized.
Evolution of Deep-Water Sinuous Channel Offshore Cameroon, West Africa, Using 3D Seismic Data
Authors: Le Anh Ngoc
Published: June 2021

Using newly acquired 3D seismic data, the deep-water sinuous channel has been discovered in the Miocene sequence on the continental margin of Cameroon, West Africa. The investigation is using high-resolution 3D seismic data, covering an area of 1500 km2, with the water depth ranging from 400 m - 2000 m. Two submarine channel systems have been documented in the northern part of the study area, the offset stacked channel and North-Northeast – Southwest channel. The offset stacked channel dimension is about 3 km wide, c. 20 km long and c. 500 ms TWT thick, extending from east to west. The evolution of this channel can be divided into three stages based on the changes in channel scale, geometry, and fill type. In the initial stage, the channel is characterized as symmetry ‘U’ shaped, bidirectional onlap, high amplitude reflections, inferring to high energy flow and sand-prone channel fill. In the following stages, the channel reduced the size and flow energy. North-Northeast – Southwest channel developed at the end of the Miocene. It is c. 3 km wide, 20 km long, 50 ms TWT thick, indicating a new sediment source for the study area. At the end of the Miocene, both channel systems show a high sinuously as an indicator of low energy flows. Uplift in the Late Miocene possibly leads to the compacted channel complex which is appeared in the anticline form, giving a great hydrocarbon trap potential for the study area.
Isotopic and Hydrochemical Study of Groundwater in an Area Between the Lesser Zab and Tigris River, Northern Iraq
Authors: Al-Kubaisi Qusai Y.
Published: June 2021

Stable isotopes (2H, 18O) in the water cycle can carry all the information about the movement of water molecules, their ratio different from one place to another in rainfall. Stable isotopes are the function of evaporation, relative humidity, temperature and different longitude, latitude and altitude. On this base. A total of 28 water sample (20 samples were analyzed for major ions and 8 samples for stable isotopes) were collected for two periods to study the origin and the type of groundwater in the area between Lesser Zab and the Tigris river The Results indicated that groundwater samples in the study area are brackish saline water and excessively mineralized water. The average groundwater was classified as Mg-Na-Calcium: Cl-Sulfate for two periods. The groundwater samples represent earth alkali with privilege sulfate and chloride according to the piper diagram. The mean values of 18H and 2O in the groundwater sample are -27.7 and -4.9, respectively for the dry period, and -29.8 and -5.2, respectively, for the wet period. The d-excess varies significantly depending on the humidity and temperature at the vapor source. Isotopic analysis of 2H -18O for groundwater in the study area shows that the origin of groundwater in the study area is of meteoric origin from global source and rain from a local source. The downward shifting of the regression line on the 2H-18O diagram indicates that the samples have undergone evaporation events.
Stratigraphic and Microfacies Study of Kometan Formation (Upper Turonian-Lower Campanian), in the Dokan area, Northern Iraq
Authors: Malak Zaid A.
Published: June 2021

The Kometan Formation is widely distributed in the northern (Kurdistan region) and central Iraq. The studied area is located near the Dokan Dam, about 58 km., to the Northwest of the Sulaymaniyah city, Northeastern Iraq. The Kometan Formation is exposed on the southwest flank of the Sarah anticline. The formation consists of limestone and dolomitic limestone, which have cherts nodules throughout the formation. The Gulneri Formation is recorded below the Kometan Formation with unconformable contact, while at the top is bounded by the Shiranish Formation unconformably too. Three microfacies are identified, these are lime mudstone, planktic foraminiferal lime wackestone-packstone, keeld planktonic foraminiferal lime wackestone-packstone microfacies. All the sedimentary and fossil evidence refer that the sedimentary environment of the formation is the outer shelf to upper bathyal at the lower and upper parts of formation and its extension to the middle bathyal in the middle part of the formation. Based on the stratigraphic ranges of the recorded Calcareous nannofossils biozones, the age of the Kometan Formation at Dokan area is Late Turonian-Early Campanian.
К вопросу об атрибуции русской оригинальной графики XX века из частных коллекций в собрании ИОХМ им. В.П. Сукачёва
Authors: Averyanova M.A.
Published: June 2021

The article is devoted to the attribution of the original graphics of the 20th century from private collections in the collection of the Irkutsk Regional Art Museum named after V.P. Sukachev. The stages of studying a particular work of art are described in detail. Attention is paid to the research of recent years, which allows us to talk about the ongoing work with objects from museum collections. As a result of the study, based on the source studies and comparative stylistic methods, it was possible to clarify the attribution of a number of illustrations to literary works, small-format watercolors and some drawings. Such works include, for example, the works of N.V. Kuzmin, T.A. Mavrina; K.S. Petrov-Vodkin, described in the article.

Статья посвящена атрибуции оригинальной графики XX века из частных коллекций в собрании Иркутского областного художественного музея им. В. П. Сукачёва. Подробно расписаны этапы изучения того или иного произведения искусства. Уделено внимание исследованиям последних лет, позволяющим говорить о непрекращающейся работе с предметами из музейных коллекций. В результате исследования с опорой на источниковедческий и сравнительно-стилистический методы удалось уточнить атрибуцию ряда иллюстраций к литературным произведениям, небольших по формату акварелей и входящих в серии рисунков. К числу таких произведений относятся, например, работы Н.В. Кузьмина, Т.А. Мавриной, К.С. Петрова-Водкина, описанные в статье.
STAKEHOLDERS’ CONTRIBUTION IN THE PROVISION OF EARLY CHILDHOOD EDUCTION IN BOTSWANA: SUCCESSES AND OBSTACLES
Authors: Mswela N. B.
Published: July 2021

This desktop study sought to consider the roles and responsibilities of various stakeholders in the provision of ECE in Botswana. The article is a document analysis study and starts by defining ECE and the importance of ECE in policies used in Botswana. It further presents the roles and responsibilities of various stakeholders in the provision of ECE services as well as ideas to improve ECE provision in Botswana.
 

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Soyada Protein Disülfit İzomeraz’ların İn Silico Analizi
Authors: DEMİREL Fatih
Published: June 2021

Protein disülfit izomerazlar protein katlanma sürecinde disülfit bağlarının doğru bir şekilde oluşmasında görev alan thioredoxin domaini içeren moleküler şaperonlardır. Hayvanlarda PDI proteinlerinin katalitik ve şaperon rollerinin araştırıldığı birçok çalışma mevcuttur. Bitkilerde ise PDI proteinlerinin varyasyonu ve fonksiyonu ile ilgili çalışmalar sınırlıdır. Bu çalışmada Arabidopsis PDI geni referans alınarak soya genomunda 12 PDI geninin varlığı gösterilmiş ve bu genlere ait proteinlerin özellikleri in silico yaklaşımlar ile ortaya konmuştur. WCXXC aktif dizi motifinin GmPDI6c ve GmPDI6d proteinlerinde korunmadığı ve diğer proteinlerde bu dizinin mevcut olduğu tespit edilmiştir. Protein modellemesi sonucunda soya PDI proteinlerinden GMQE skoru en yüksek olanı ele alınarak Tobacco ringspot virus’e ait kılıf proteini arasındaki etkileşim docking ile ortaya konmuştur. Çalışma sonucunda elde edilen in silico analiz sonuçlarının deneysel yaklaşımlar ile doğrulanması gerekmektedir.
ANALISIS PEMBIAYAAN PRODUKTIF TERHADAP JUMLAH NASABAH PADA KOPERASI KARYAWAN SAMUDERA TONASA LINES KABUPATEN PANGKEP
Authors: Basir Muhammad , Renreng Mulyahati
Published: July 2021

Penelitian ini bertujuan untuk mengetahui dan menganalisis pemberian pembiayaan produktif dalam meningkatkan jumlah nasabah pada Koperasi Karyawan Samudera Tonasa Lines Kabupaten Pangkep.Metode analisis Asosiatif, Metode ini digunakan untuk mengetahui hubungan antara dua variable atau lebih dan tidak saling mengikat yang menjelaskan, meramalkan dan mengontrol suatu fenomena.Hasil penelitian menunjukkan bahwa Koperasi Karyawan Samudera Tonasa Lines Kabupaten Pangkep berhasil meningkatkan pembiayaan produktif terhadap peningkatan jumlah nasabah dalam tiga tahun terakhir dari tahun 2017 hingga tahun 2019