bluuebunny/crossref_metadata_2025 huggingface dataset:
Recomendaciones de la Asociación Colombiana de Neurología para el uso de anticuerpos monoclonales antiCGRP en la profilaxis de migraña
Authors: Pradilla Oscar Enrique , Martinez José David , Rueda-Sánchez Mauricio , Sobrino Fidel , Jiménez Juan Diego , Ramírez Sergio Francisco , Muñoz-Cerón Joe Fernando , Volcy Michel , Guerra Carolina , Ramos Marta Liliana , Arango Esteban , Uribe Bernardo , Cavanzo Paula , Hernández Natalia
Published: September 2023

INTRODUCCIÓN:
El desarrollo de anticuerpos monoclonales (mAbs) contra el péptido relacionado con el gen de la calcitonina (CGRP) ha determinado una nueva era terapéutica en la profilaxis de migraña, demostrando su efectividad en pacientes con migraña episódica (ME) y migraña crónica (MC), con respuesta desde pacientes naïve hasta refractarios a múltiples medicamentos. La disminución del 50% de los ataques de migraña al mes (DMM) durante los primeros 3 meses de uso es el desenlace aproximado en el 50% de los pacientes que reciben esta terapia.

OBJETIVO:
Este consenso de la Asociación Colombiana de Neurología (ACN) tiene el objetivo de guiar la selección y uso racional de los mAbs antiCGRP en pacientes con ME y MC.

MATERIALES Y MÉTODOS:
El comité de cefalea de la ACN mediante la aplicación de la metodología Delphi y discusiones en reuniones posteriores desarrolló un documento en formato de consenso soportado en literatura y recomendaciones de expertos.

RESULTADOS:
Se obtuvieron respuestas de 14 expertos en cefalea sobre moléculas utilizadas en profilaxis de migraña, analizando su aplicabilidad en situaciones clínicas frecuentes.

DISCUSIÓN:
Los mAbs antiCGRP han demostrado efectividad con adecuado soporte fisiopatológico, considerando que son moléculas de alto precio en una enfermedad de alta prevalencia, existe la necesidad de guíar la selección del paciente que mejor puede beneficiarse de su administración

CONCLUSIONES:
Los mAbs antiCGRP están recomendados en pacientes con ME y MC que presentan falla terapéutica a otras moléculas profilácticas.
AVALIAÇÃO DA APLICAÇÃO DO RESÍDUO DA ANNONA MURICATA L. COMO INIBIDOR DE CORROSÃO ECOLÓGICO
Authors: Ferreira de Lima Rafael Rodrigo
Published: September 2023

Nesse trabalho foi investigada a ação inibitória do extrato em pó da Annona muricata L. produzido a partir das sementes do fruto. Para isto, ensaios gravimétricos foram realizados em amostras de aço microligado em meio ácido, variando a concentração do extrato. Os resultados dos ensaios gravimétricos mostraram que a eficiência do inibidor de corrosão aumenta com o aumento da concentração do mesmo. As isotermas de adsorção mostraram que as moléculas do inibidor se adsorvem sobre a superfície do aço via adsorção química e seguem o modelo de Langmuir. As análises de microscopia óptica (MO) e microscopia eletrônica de varredura (MEV) mostraram que realmente um filme de inibidor é formado e que este bloqueia a superfície e minimiza os processos corrosivos. A maior potencialidade de inibição ocorreu na concentração de 0,08mg/L, onde o filme formado é mais compacto e homogêneo, o que permitiu a redução significativa de pites sobre a superfície do material.
WHAT TO LOOK FOR IN CHEST X-RAYS OF PEDIATRIC PATIENTS WITH COVID-19: INSIGHTS FROM A COLOMBIAN COHORT.
Authors: Vanegas Melisa Sofía Naranjo , Burgos Claudia , Mendez Laura Melissa , Rodriguez María Margarita , Martinez Arianna , Sanchez Paola , Tovar Carolina , Vasquez-Hoyos Pablo , Mesa-Rubio María Lucia , Triana Gustavo , Royero-Arias Mónica , Echeverry Jessica , Gamo Tamara , Moreno Luz Ángela , Castañeda Olga Lucía Baquero , Restrepo-Gualteros Sonia , Moreno-Lopez Sergio , Galvis Clara , MORALEDA CINTA , TAGARRO ALFREDO , Ramirez Andrea , Friedrich Gabriela , Mejía Luz Marina , Ramirez Luis Miguel Navarro , Piñeros Juan Gabriel , Alvarez-Moreno Carlos , Díaz-Díaz Alejandro , Gutierrez-Tobar Iván , Nieto José Manuel , Gastegi Irati
Published: September 2023

Background: Despite advancements in vaccination and the
transition from pandemic to endemic, SARS-CoV-2 continues to pose a
medical challenge, particularly among children. In this context, imaging
diagnostics, such as chest x-rays, are crucial to the initial treatment
of patients. This study aims to characterize the radiological findings
in pediatric patients with confirmed SARS-CoV-2 infection in Colombia
between April 2020 and November 2021, as well as their potential
association with intensive care admission. Methods: In
Colombia, a multicenter cohort comprised patients aged 29 days to 17
years with confirmed SARS-CoV-2 infection and chest X-ray administered
within 72 hours of hospitalization. In two separate groups, four
radiologists evaluated the images. A fifth radiologist reviewed all the
X-rays; and subsequently, these readings were used to calculate the
kappa coefficient and to resolve discrepancies among the other
radiologists. The results were compared to admission to intensive care.
Results: Analysis was conducted on 392 patients with a mean age
of 2 years, the majority of whom (42%) were infants. Sixty-eight
percent of the radiographs had normal results. Peribronchial thickening
and interstitial opacity were the most common aberrant findings (59%),
followed by alveolar opacity (12%). 88 percent of findings were
bilateral. The most common association between peribronchial thickening
and intensive care admission was ventilatory failure. Interobserver
agreement was low for peribronchial thickening (kappa = 0.1), but higher
for consolidations and alveolar opacities (kappa = 0.4 and 0.5,
respectively). Conclusion: In pediatric patients with
SARS-CoV-2, radiological findings are nonspecific and interobserver
agreement is minimal. Although consolidation and alveolar opacities
demonstrated greater concordance, they were not associated with clinical
differences; therefore, chest radiography is not considered useful for
determining the severity of COVID-19 in children.
PHENOTYPIC VARIATION IN DISEASE SEVERITY AMONG HOSPITALIZED PEDIATRIC PATIENTS WITH COVID-19: ASSESSING THE IMPACT OF COVID-19 IN THE EPICO STUDY
Authors: Vanegas Melisa Sofía Naranjo , Sossa María Camila , Gutiérrez Mónica Paola , Becerra Natalia , Ortegon Luz Yessenia , David María Camila , Vasquez-Hoyos Pablo , Mesa-Rubio María Lucia , Moreno-Lopez Sergio , Castañeda Olga Lucía Baquero , Restrepo-Gualteros Sonia , Galvis Clara , Africano Martha , MORALEDA CINTA , TAGARRO ALFREDO , Herrero Blanca , Grasa Carlos , Soriano-Arandes Antoni , Ramirez Andrea , Ramirez Luis Miguel Navarro , Friedrich Gabriela , Díaz-Díaz Alejandro , Alvarez-Moreno Carlos , Piñeros Juan Gabriel , Mejía Luz Marina , Gutierrez-Tobar Iván , Mesa Andrés Camilo , Tuta William Ricardo Bachiller , Nieto José Manuel , Camacho Paola Marcela Pérez , Beltrán-Arroyave Claudia , Trochez Rosalba Vivas , Gastegi Irati , Rodriguez-Molino Paula , Melendo Susana , Pastrana Irene Gómez , García Sonsoles García , Fumadó Victoria , Calleja Lourdes
Published: September 2023

Background: SARS-CoV-2 infection has been extensively
documented since the onset of the pandemic, particularly in the adult
population. However, there is a lack of evidence describing the
phenotypic manifestations of the disease in the pediatric population. We
aimed to characterize the clinical phenotypes of SARS-CoV-2 infection in
hospitalized children. Methods: The EPICO study is a
multicenter cohort conducted between April 2020- November 2021,
involving 55 institutions in Spain and 13 institutions in Colombia.
Hospitalized children aged 29 days to 17 years with confirmed SARS-CoV-2
infection were included to determine the disease´s evolution, severity
factors, and outcomes. Cluster analysis was conducted to characterize
clinical phenotypes. Results: A total of 2318 patients from
Colombian and Spanish institutions were included. The population was
55% male, with infants being the largest group (36%). Five distinct
phenotype clusters emerged, differing significantly in clinical and
epidemiological characteristics. Cluster 1 (26.57%) consisted of
infants without comorbidities, with low PICU admission and mortality
rates. Cluster 2 (18.5%) had respiratory comorbidities, high
co-detection, and mortality rates. Cluster 3 (11.51%) showed fever,
gastrointestinal symptoms, and high PICU admission. Cluster 4 (32.09%)
had mild unspecific symptoms and low mortality. Cluster 5 (11.3%)
included adolescents without comorbidities, with low co-detection and
hospitalization rates. Comparable findings were observed in both
countries. Conclusion: Our study successfully identified
distinct patterns of clinical and epidemiological characteristics
associated with SARS-CoV-2 infection in hospitalized pediatric patients.
These findings may help shape future guidelines and improve risk
stratification in children.
SPATIAL DISTRIBUTION AND LANDSCAPE IMPACT ANALYSIS OF QUARRYING IN A HIGHLY FRAGMENTED ECOSYSTEM
Authors: Carabia-Sanz Irati , Simoy María V. , Cortelezzi Agustina , Trofino-Falasco Clara , Berkunsky Igor
Published: September 2023

Quarrying generates significant changes in the grasslands, by reducing
ecological functions, reducing connectivity, impairing biodiversity, and
degrading soil. Unlike other forms of destruction such as agriculture or
urbanization, mining is characterized by eliminating soil and exposing
the bedrock, facilitating groundwater contamination processes. Quarrying
in Pampean grassland has been expanding for a century and little is
known about the extent and distribution of quarries over the native
environment. In this work, we analyze the spatiotemporal variation of
quarrying activity on the Highland grassland in the Tandilia mountains
of Argentina. Based on Landsat 5, 7, and 8 satellite imagery, from 1996
to 2022, and using QGIS software, we identified the location and
extension of quarries, and we analyzed their change through time.
Quarries covered 6428 ha, which was originally part of the Pampean
grassland. The number of open quarries increased by 129%, from 69 in
1996 to 158 in 2022, and the area used for this activity increased by
172%, with a greater expansion being detected in the last ten years. At
least 87 quarries were abandoned in 2022. Quarries are often abandoned
without any kind of remediation, leading to further ecosystem
deterioration. The current extension of quarrying activity (active and
abandoned quarries) reduced the connectivity and a significant area
(5.2%) of the Highland grassland of the Tandilia Mountains. Grassland
conservation planning should include quarrying as a significant threat,
and management actions must be considered to reduce its impact.
PIEZO1-related Hereditary Xerocytosis in a boy with cardiac arrhythmia
Authors: Aslan Deniz
Published: September 2023

Hematological evaluation to explain indirect hyperbilirubinemia in a boy
with cardiac arrhythmia showed the presence of PIEZO1-related hereditary
xerocytosis (HX) [c.6008C>A (p.Ala2003Asp) variant]
presenting with compensated hemolytic anemia and splenomegaly. PIEZO1
expression is not limited to erythrocytes and can also be found in other
types of cells. It has been shown very recently that PIEZO1 is expressed
in cardiomyocytes and chemically prolonging PIEZO1 activation results in
cardiac arrhythmias. Since no other causative variants were detected in
genes previously associated with cardiac arrhythmias, the arrhythmia was
attributed to the PIEZO1 variant underlying HX. Arrhythmias can be fatal
and we recommend that cardiac evaluation be part of the examination in
patients with PIEZO1-related HX.
Improved prognostic value of recurrence for atrial fibrillation patients after cryoablation by non-linear survival models
Authors: Li Jing , Liao Xuewen , Chen Lin , Yang Zhi-Ping , Chen Jian-Quan , Zhang Jian-Cheng , Lin Yazhou , Chen Xiaoping
Published: September 2023

Background: Atrial fibrillation (AF) is a common cardiac
arrhythmia that affects millions of people worldwide. We aim to
investigate how to improve prognostic value of recurrence for atrial
fibrillation patients after cryoablation by non-linear survival models.
Methods: In this study, we retrospectively reviewed data from
1023 patients who underwent cryoablation surgery for AF at Fujian
Provincial Hospital (FPH). We generated radiomics signatures (RSI) and a
clinical signature (CLI) using a non-linear survival model by repeated
10-fold cross-validation. The comprehensive risk score (TCRS) was
obtained by linearly weighting the multivariate Cox proportional risk
model. Results: The combination of RSI and CLI indicators had a
significantly higher area under the curve (AUC) in the ROC curve of the
training set (AUC=0.955) compared to the AUC of a single indicator CLI
(AUC=0.862). The TCRS showed better prognostic performance compared to
the traditional Lasso-Cox models, with AUC of 0.955 vs 0.664. The
accuracy of the model was further confirmed by the C-indices of RSI
(C-index: 0.8894; 95%CI: 0.8166-0.9621), CLI (C-index: 0.8431; 95%CI:
0.7466-0.9395), and TCRS (C-index: 0.9072; 95%CI: 0.8281-0.9864) in
validation set 2. Conclusions: Under a nonlinear survival
model, TCRS which combines RSI and CLI indicators has potential as a
promising prognostic tool for post-cryoablation AF patients.
Utility of Multi-spline Multi-electrode 3D Mapping Catheters in Idiopathic Outflow Tract Ventricular Tachycardia.
Authors: Kerley Robert , Keane David
Published: September 2023

We describe two cases of idiopathic VT arising from the postero-septal
RVOT in both cases. Each case demonstrates an important learning point
and advantage of multi-spline multi-electrode mapping catheters in
idiopathic outflow VT. In the first case two dominant PVC morphologies
can be clearly seen which we believe originate from a single site of
origin with multiple exit sites caused by focal fibrosis. In the second
case, focal fibrosis in this region leads to anisotropic conduction of
the RVOT in areas of low voltage. We surmise that multi-spline
multi-electrode catheters are essential in such cases as extensive
point-by-point mapping could significantly prolong procedure time and
fail to identify the earliest activation site in the case of anisotropic
tissue conduction due to variations in activation latency.
Exploratory associations of tacrolimus exposure and clinical outcomes after lung transplantation: a retrospective, single center experience
Authors: Du Wenwen , Wang Xiaoxing , Zhang Dan , Chen WenQian , Zuo Xianbo
Published: September 2023

Aims: This study aimed to investigate the potential impact of tacrolimus
(TAC) exposure on clinical outcomes after lung transplantation. Methods:
This retrospective observational study enrolled a total of 234 lung
transplant recipients. TAC trough levels (C) were
collected for 3 intervals: 0–3 months, 3–12 months, and 12–24 months.
The intra-patient variability (IPV) was calculated using coefficient of
variation. Genotyping of CYP3A5*3 (rs776746) was performed.
Patients were further divided into groups based on the
C cut-off value of 8 ng/mL and IPV cut-off value of
30%. Cox proportional hazards regression models were used to explore
the potential impact of C and IPV on outcomes of
interests, including donor-specific antibodies (DSA), chronic lung
allograft dysfunction (CLAD) and mortality. Results: The influence of
CYP3A5*3 polymorphism was only significant for C
and IPV during the first 3 months. Low C (< 8
ng/mL) at 3–12 months increased the risk of DSA (hazard ratio [HR]
2.820, 95% confidence interval [CI] 1.093–7.276) and mortality (HR
2.220, 95% CI 1.162–4.243), while High IPV (>=30%)
during this period was associated with an increased risk of mortality
(HR 2.100, 95% CI 1.120–3.937). Patients with Low
C/High IPV combination had significantly higher risks
for DSA (HR 4.534, 95% CI 1.326–15.507) and survival (HR 4.205, 95%
CI 1.739–10.168), surpassing the predictive power provided by
C or IPV alone. Conclusion: A combination of Low
C/High IPV might be considered in categorizing patients
towards risk of adverse clinical outcomes following lung
transplantation.
Monetary Policy, Macroeconomic and Anomalies Interactions Post COVID in Developed and Eastern European Stock Markets
Authors: Mohd Yusoff Zetty Zahureen , Bahrudin Nur Zahidah , Suryani Ani Wilujeng
Published: September 2023

The purpose of this study is to examine the crucial factors amongst monetary policy and macroeconomic variables that spike the anomalies momentum on stock markets post-COVID-19 pandemic in selected Developed and Eastern European countries. This study uses panel data to measure the cross interactions of five stock exchanges based on unprecedented recovery in the European stock markets that yield astonishingly higher returns post-COVID-19, believed to be due to a perfect adoption of monetary policies (Exchange and Inflation Rates) and macroeconomic factor (Economic Growth) from January 2017 to December 2022. Findings suggest that the Exchange Rate and Economic Growth of the country are positively significant in influencing the Stock Market Performance in European stock markets. Additionally, the Inflation Rate surprisingly is negatively related to Stock Market Performance. Furthermore, local and foreign investors prefer to invest in a country that has a great adoption of monetary policies (stable Exchange Rate and lower Inflation Rates) as well as macroeconomic variables (resilient Economic Growth) for post COVID-19 economic landscape. For practical implications, the study suggests that the stock market performance, exchange rate, inflation rate, and economic growth of the country should be maintained and improved to attract fund inflows from local and foreign investments.  To the best of the authors’ knowledge, this study is the first that examines the anomalous market momentum effect post-COVID-19 pandemic focusing on aspects, monetary policy, and macroeconomic variables. The momentum effect investing strategies that provide abnormal returns in different stock markets truly existed.
The Study on the Factors Affecting Employees' Quitting Intention in Malaysian Manufacturing Sector
Authors: Mahmad Khairubi , Kamarul Zaman Maliza Delima
Published: September 2023

To understand how ethical leadership, emotional leadership, and transformational leadership impact employees' intention to quit in the Malaysian manufacturing industry, a study was undertaken. In this study, a quantitative technique was utilized to gather data from a sample of 175 employees selected from industrial enterprises in the Klang Valley, Malaysia by the use of an online questionnaire. As a means of gathering data, a verified questionnaire with pertinent questions for the study was used. The research findings indicated that there were negative relationships between ethical leadership, transformational leadership and emotional leadership with quitting intention. This showed that employees will have less intention to quit with the increase in ethical leadership, emotional leadership as well and transformational leadership.  It also led to further understanding that transformational leadership and emotional leadership had significant effects on employees’ intention to quit respectively. These findings were hoped to help organization leaders keep their employees motivated and satisfied with their jobs to make them loyal customers to the company. This study was carried out with employees as the respondents and was set to be in the manufacturing sector in Klang Valley, Malaysia which included all of Selangor's major districts. This was done by choosing samples from different districts that were actively engaged in the manufacturing sector.
The Effect of Organizational Innovation Mediates between Knowledge Management Capabilities and Hotel Performance: A Conceptual Analysis
Authors: Syed Mohamad Syed Jamal Abdul Nasir , Muhamad Nor Nor Shahrul Nizam , Fikry Amily , Abdul Aziz Muhammad Ridzuan
Published: September 2023

The mediation relationship of organizational innovation (OI) between knowledge management capabilities (KMC) and hotel performance (HP) in Malaysia is the focus of this study. According to the World Tourism Organization (2018), around 1.245 billion foreign tourists visited the world in 2016, and the business is expected to generate trillions of dollars in revenue. Unfortunately, this industry has been impacted by the COVID-19 pandemic, which began in early 2020 but has since slowly recovered since 2022 (UNWTO, 2022). To survive in the cut-throat climate, hoteliers in the tourism sector must adopt the prevailing fashion. As a result, hoteliers must equip their staff with the necessary knowledge of infrastructure and processes to handle organizational innovation to ensure they can perform and survive. Nonetheless, a large number of them continue to resist knowledge management adaptation as a creative organization. This initial stage of the conceptual paper is the development of knowledge management, organizational innovation and hotel performance. The data were collected from selected hotels among their top management such as chief executive officers, general managers, managing directors or department managers that represent three-star to five-star hotels in Malaysia by using simple random sampling from the list provided by the Ministry of Tourism, Art and Culture of Malaysia. The result can be expected to assist organizations including hoteliers to sustain competitiveness by having knowledge management capabilities and organizational innovation in the market.
Challenges to Women’s Economic Empowerment in Rural Tajikistan: A Study from Road Projects
Authors:   Asian Development Bank, Idei Rika , Taniguchi Kiyoshi ,   Asian Development Bank, Bakhtibekova Zulfiya ,   Independent Researcher
Published: September 2023

This brief analyzes ways to economically empower women in rural Tajikistan and highlights how better integrating measures into the development of critical transport infrastructure projects can help narrow the substantial gender gap. It assesses why Tajik women’s educational attainment is lower, shows how they are under-represented in the job market, and explains the challenges posed by deep-rooted intrafamilial hierarchies. Drawing on survey results, it shows how women benefitted from ADB transport projects that included empowerment activities and explains why understanding cultural norms and providing help to start businesses can boost women’s socioeconomic capacity.
Building Capacity for an Effective Social Welfare System in Mongolia
Authors: Schelzig Karin , Carraro Ludovico , Byambaa Enkhtsetseg
Published: September 2023

This working paper explores four themes in the design and delivery of social welfare in Mongolia: (i) the rationale for social welfare, (ii) whether welfare dependency is an issue, (iii) how the Government of Mongolia can strengthen the shock-responsiveness of its social protection system, and (iv) how a global innovation in social protection can help vulnerable Mongolians graduate from poverty and achieve economic inclusion. It synthesizes key findings from four policy briefs prepared at the request of Mongolian social protection policymakers with Asian Development Bank technical assistance (Building Capacity for an Effective Social Welfare System, 2019–2023).
Relative controllability of conformable delay differential systems with linear parts defined by permutable matrices
Authors: Zhou Airen , Wang Jinrong
Published: September 2023

We study relative controllability of linear and nonlinear conformable delay
differential systems with linear parts defined by permutable matrices. By
using a notion of delay Grammian matrix, we give a sufficient and necessary
condition to examine that a linear delay controlled systems is relatively
controllable. Thereafter, we construct a suitable control function for
nonlinear delay controlled system, which admits us to adopt the framework of
fixed point methods to investigate the same issue. More precisely, we apply
Krassnoselskii?s fixed point theorem to derive a relative controllability
result. Finally, two examples are presented to illustrate our theoretical
results with the help of computing the desired control functions and inverse
of delay Grammian matrix as well.
Additive property for the generalized Zhou inverse in a Banach algebra
Authors: Abbasi Abbas , Bahmani Rahman , Abdolyousefi Marjan , Ashrafi Nahid
Published: September 2023

Let A be a Banach algebra. An element a ? A has the generalized Zhou inverse
if there exists b ? A such that b = bab, ab = ba, an ? ab ? J#(A), f or some
n ? N. We find some new conditions under which the generalized Zhou inverse
of the sum a + b can be explicitly expressed in terms of a, b, az, bz. In
particular, necessary and sufficient conditions for the existence of the
generalized Zhou inverse of the sum a + b are obtained.
An algorithmic approach for a system of extended multi-valued variational-like inclusions in Banach spaces
Authors: Balooee Javad , Postolache Mihai , Yao Yonghong
Published: September 2023

In this paper, we pursue two purposes. Our first goal is to study a new
system of extended multi-valued nonlinear variational inclusions in Banach
spaces and to establish its equivalence with a system of fixed point
problems with the help of the concept of (H, ?)-proximal mapping. The
obtained alternative equivalent formulation is used and a new iterative
algorithm for finding its approximate solution is proposed. Under some
appropriate assumptions imposed on the mappings and parameters involved in
the system of extended multi-valued nonlinear variational inclusions, the
existence of solution for the system mentioned above is proved and the
convergence analysis of the sequences generated by our suggested iterative
algorithm is discussed. The second objective of this paper is to investigate
and analyze the notion of Cn-?-monotone mapping, which is an extension of
the concept of Cn-monotone mapping, and to point out some remarks relating
to Cn-?-monotone mapping and the results concerning it appeared in the
literature. The results presented in this paper are new, and improve and
generalize many known corresponding results.
On the weighted maximal operators of Marcinkiewicz type Cesàro means of two-dimensional Walsh-Fourier series
Authors: Blahota István , Nagy Károly
Published: September 2023

In this paper we investigate the behaviour of the weighted maximal operators
of Marcinkiewicz type (C,?)-means ??,* p (f) := supn?P |??n(f)|/
n2/p?(2+?) in the Hardy space Hp(G2) (0 < ? < 1 and p < 2/(2 + ?)). It is
showed that the maximal operators ??,* p (f) are bounded from the dyadic
Hardy space Hp(G2) to the Lebesgue space Lp(G2), and that this is in a sense
sharp. It was also proved a strong convergence theorem for the Marcinkiewicz
type (C, ?) means of Walsh-Fourier series in Hp(G2).
Oxidation of 1,5-benzodiazepine oximes catalysed by peroxidases
Authors: Kosychova Lidija , Rekovic Lina , Bratkovskaja Irina , Radveikiene Ingrida , Vidziūnaitė Regina
Published: September 2023

Oxidation of 1,3,4,5-tetrahydro-2H-1,5-benzodiazepine oximes catalysed by horseradish peroxidase (HRP) and recombinant Coprinus cinereus peroxidase (rCiP) was studied spectrophotometrically. The reaction rate dependences on the substrate and hydrogen peroxide concentrations were investigated; the values of apparent KM and Vmax, catalytic, oxidation and reduction constants (kcat, kox and kred, respectively) were calculated. The reactivity constants for the reactions catalysed by rCiP were higher than those for the HRP. Since oximes can have different structures depending on pH, the influence of pH on the rate of oxidation of compounds was studied. The dependences of the oxidation rate of the investigated oximes on the pH of the buffer solution were determined, and the pKa values of the amino acids of peroxidases responsible for the rate of catalysis were obtained. The HRP activity dependence on pH has a classical bell-shaped character, while rCiP dependence has a complex character.
Effectiveness of Tofacitinib in Pre-adolescent Alopecia Areata: A Retrospective Case Series and Literature Review
Authors: Huang Jundong , Li Tingting , Tan Zixin , Tang Yan , Li Ji , Liu Fenfang , Shi Wei
Published: September 2023

Alopecia areata (AA) is a common cause of hair loss in children. Despite numerous therapeutic options for paediatric AA, none have been found to be both effective and safe. Recent studies have demonstrated the efficacy and safety of the Janus kinase (JAK) inhibitor tofacitinib in adult patients with AA, whereas data on paediatric patients with AA in real-world practice are limited. This was a single-centre, retrospective study that included 11 pre-adolescent patients with AA treated with tofacitinib between December 2021 and September 2022. Clinical characteristics of patients, clinical response and adverse events were evaluated. Overall, 82% (9/11) of patients experienced hair regrowth and 64% (7/11) of patients experienced over 50% improvement in their Severity of Alopecia Tool (SALT) scores. Adverse events were mild. In the literature, tofacitinib has been used to treat AA in 31 children ≤12 years of age who failed to respond to prior treatments. Eighty-seven percent (27/31) of these patients showed significant responses based on changes in their SALT scores. This case series demonstrates that oral tofacitinib is an effective and safe treatment option for paediatric AA, particularly for children who have failed to respond to traditional treatments or are not suitable for such treatments.
A Case of Bowen’s Disease in the Periungual Region: Raising the Possibility of Genitodigital Transmission of Human Papillomavirus Between Sexual Partners
Authors: Kim Ho Sung , Uh Ji An , Kim Myoung Shin , Lee Un Ha , Lee Soo-Kyung
Published: September 2023

Abstract is missing (Short communication)
Essential requirements for the governance and management of data trusts, data repositories, and other data collaborations
Authors: Paprica P Alison , Crichlow Monique , Curtis Maillet Donna , Kesselring Sarah , Pow Conrad , Scarnecchia Thomas P. , Schull Michael J. , Cartagena Rosario G. , Cumyn Annabelle , Dostmohammad Salman , Elliston Keith O. , Greiver Michelle , Hawn Nelson Amy , Hill Sean L. , Isaranuwatchai Wanrudee , Loukipoudis Evgueni , McDonald James Ted , McLaughlin John R. , Rabinowitz Alan , Razak Fahad , Verhulst Stefaan G. , Verma Amol A. , Victor J. Charles , Young Andrew , Yu Joanna , McGrail Kimberlyn
Published: September 2023

IntroductionAround the world, many organisations are working on ways to increase the use, sharing, and reuse of person-level data for research, evaluation, planning, and innovation while ensuring that data are secure and privacy is protected. As a contribution to broader efforts to improve data governance and management, in 2020 members of our team published 12 minimum specification essential requirements (min specs) to provide practical guidance for organisations establishing or operating data trusts and other forms of data infrastructure.
Approach and AimsWe convened an international team, consisting mostly of participants from Canada and the United States of America, to test and refine the original 12 min specs. Twenty-three (23) data-focused organisations and initiatives recorded the various ways they address the min specs. Sub-teams analysed the results, used the findings to make improvements to the min specs, and identified materials to support organisations/initiatives in addressing the min specs.
ResultsAnalyses and discussion led to an updated set of 15 min specs covering five categories: one min spec for Legal, five for Governance, four for Management, two for Data Users, and three for Stakeholder & Public Engagement. Multiple changes were made to make the min specs language more technically complete and precise. The updated set of 15 min specs has been integrated into a Canadian national standard that, to our knowledge, is the first to include requirements for public engagement and Indigenous Data Sovereignty.
ConclusionsThe testing and refinement of the min specs led to significant additions and improvements. The min specs helped the 23 organisations/initiatives involved in this project communicate and compare how they achieve responsible and trustworthy data governance and management. By extension, the min specs, and the Canadian national standard based on them, are likely to be useful for other data-focused organisations and initiatives.
Ler-escrever gêneros discursivos acadêmicos como processo formativo de uma turma de licenciatura em pedagogia vinculada ao PARFOR
Authors: Rodrigues Jéssica do Nascimento , Mello Marcela Tavares de
Published: September 2023

Esta pesquisa qualitativo-interpretativista focaliza as apreciações valorativas (BAKHTIN, 2011) de estudantes, já professores, de um curso de Pedagogia vinculado ao PARFOR, acerca das dificuldades de vivência nas práticas cotidianas de escrita universitária e do trabalho desenvolvido pelo professor universitário no ensino de gêneros da esfera acadêmica no decurso das disciplinas. Em termos metodológicos, aplicou-se um questionário respondido oralmente em videogravação por três estudantes em 2018. Entendendo que as práticas de escrita são práticas sociais situadas em esferas discursivas não isentas de relações hierárquicas, ideológicas e de poder (STREET, 2014), ancora-se esse debate nos Estudos do Letramento (LEA; STREET, 1998; LILLIS, 1999; STREET, 2010, 2014 etc.), na Filosofia da Linguagem (BAKHTIN, 2011) e em pesquisas que imbricam formação docente e letramento acadêmico (VIANNA et al, 2016; RODRIGUES; RANGEL, 2018 etc.). As apreciações valorativas produzidas refletem-refratam “dimensões escondidas” entre a solicitação e a produção de gêneros acadêmicos, cuja escrita é demandada sistematicamente pelos professores. Embora as apreciações valorativas indiquem a aquisição de mais experiência nessa modalidade, a pressuposição de que os estudantes não só devem conhecer como ainda dominar de antemão tais gêneros é um fator dificultador de vivências significativas de escrita, porque minimiza-se o espaço do ensinar na esfera acadêmica.
A Study on Knowledge, Attitudes, Practice and Awareness towards Pre-Marital Carrier Screening of Thalassemia among the University Students of Biological Faculty in Bangladesh: A Cross-Sectional Study
Authors: Mia Md. Al- Tareq , Islam Md. ReJaul , Sarker Anamika , Shahriar Esha Binte , Hasan Aminul , Ayon Rubiat Afrin , Khalil Md. Ibrahim , Hossain Moazzem , Hossain Md. Ibrahim
Published: September 2023

Thalassemia is a hereditary hemoglobinopathies that results from the absence of a globulin chain and it is a very common problem in Southeast Asia. Like many other countries’ community based premarital carrier screening (PMCS) of thalassemia is extremely rare in Bangladesh. This study aimed to investigate knowledge, attitude, practice, and awareness towards PMCS among University students in Bangladesh. A cross-sectional study was conducted from January to March 2020 using a self-administered questionnaire which was distributed to 911 Jahangirnagar University students aged 18 to 24. The questionnaire was composed of five parts: personal information, knowledge, attitudes, practice, and awareness. On the basis of the answers, knowledge, attitudes, practice, and awareness towards PMCS were evaluated. About (88.80%) of the total participating students thought that PMCS is necessary before marriage. In the case of thalassemia carrier parents, 81.00% of students replied that prenatal screening is important before pregnancy. 610 students (66.95%) of the total 911 students considered that thalassemia can be caused by marrying between blood relatives. Most of the students (79.80%) supported that thalassemia screening should be an obligatory procedure and 91.98% would like to raise social awareness about PMCS and thalassemia. The students of Jahangirnagar University have good knowledge about PMCS program and a positive attitude but it is difficult to implement in real life without continuing practice. The outcome of this study suggested the necessity of increasing student’s awareness of Bangladeshi PMCS program.
Analisis Perbedaan Perilaku Investasi Saham Antara Wanita dan Pria di Pasar Modal Indonesia
Authors: Putri Feby Amalia , Mulyani Erly
Published: September 2023

This study aims to analyze 1) Do women have a tendency to have low financial literacy compared to men in making stock investment decisions. 2) Do women have a tendency to be not overconfident than men in making stock investment decisions. 3) Do women have a tendency to have low risk tolerance compared to men in making stock investment decisions. 4) Do women have a tendency to herding behavior compared to men in making stock investment decisions. The novelty of this research from the previous one is that the author places more emphasis on gender differences in decision making when influenced by behavioral finance bias. This study uses quantitative methods with data collection techniques using questionnaires distributed through online media to investors with a sample of 146 investor respondents. The sample is distributed to respondents who are listed on the IDX of West Sumatra. The analytical method used in this research is descriptive analysis and Mann-Whitney test. The results of the study found 1) There is no significant difference between the financial literacy of women and men in making stock investment decisions. 2) There is a significant difference between overconfidence of women and men in making stock investment decisions, and female investors tend to be not overconfident than men in making stock investment decisions. 3) There is a significant difference between the risk tolerance of women and men in making stock investment decisions, and female investors tend to have low risk tolerance compared to men in making stock investment decisions. 4) There is a significant difference between the herding behavior of women and men in making stock investment decisions, but male investors tend to have high herding behavior compared to women in making stock investment decisions.
Analisis Praktik Corporate Social Responsibility (CSR) Saat Pandemi Covid-19 pada Perusahaan Farmasi
Authors: Wahyuni Liza , Cheisviyanny Charoline
Published: September 2023

This study aims to analyze: 1) the level and quality of Corporate Social Responsibility (CSR) disclosure during the Covid-19 in pharmaceutical companies based on the 2021 GRI Standards, 2) Corporate Social Responsibility (CSR) practiced by pharmaceutical companies in helping to overcome the Covid-19 based on the 2021 GRI Standards. This research is a qualitative research using content analysis methods. The research was conducted on pharmaceutical sector companies in Indonesia by taking 4 samples of companies, namely PT Indofarma Tbk, PT Kalbe Farma Tbk, PT Phapros Tbk, and PT Sido Muncul Tbk. The data used is data for 2019-2020 when the Covid-19 entered Indonesia. The research data comes from the company's sustainability report. The results of content analysis show that the Covid-19 has played a major role in the disclosure of Corporate Social Responsibility (CSR) in the pharmaceutical sector. Two of the four companies that were the subject of the study had quite high Corporate Social Responsibility (CSR) disclosures, namely PT Kalbe Farma and PT Sido Muncul Tbk. Four companies that are active research subjects provide assistance in the form of donations to the community in efforts to tackle the Covid-19.
Pengaruh Good Corporate Governance terhadap Kinerja Keuangan Perusahaan
Authors: Titania Helin , Taqwa Salma
Published: September 2023

This study aims to determine the effect of good corporate governance on financial performance. The independent variable in this study is good corporate governance which is proxied to be an independent board of commissioners, audit committee, and managerial ownership, while the dependent variable of this study is financial performance which is proxied by Tobin's Q. The subject of this study is BUMN companies, with the study population being all BUMN companies listed on the Indonesia Stock Exchange. The type of data used is secondary data in the form of annual financial reports of BUMN companies listed on the Indonesia Stock Exchange in the period 2019-2021. The technique used for sampling is the purposive sampling and the method used for hypothesis testing is multiple linear regression analysis. The results showed that the independent board of commissioners variable had a significant positive effect on financial performance, the audit committee had no effect on financial performance, and managerial ownership had no effect on financial performance.
Pengaruh Faktor Politik dalam Pengungkapan Transparansi Informasi Website Pemerintah Daerah: Studi Empiris Kabupaten/Kota Pulau Jawa dan Bali Periode 2017-2020
Authors: Mistika Mega , Deviani Deviani
Published: September 2023

This research aims to determine the effect of political factors such as political strength and political competition level on transparency information of local government websites in Java and Bali. The sampling techniques used was purpose sampling with a total of 122 local government websites using multiple linear regression with the help of IBM SPSS 23 software. This result shows that political strength and political competition level does not affect the transparency of local government. There is no effect on transparency when the pressure from public and political party were high. In addition, people must remain wary of information from local government to hold them accountable.
THE MARKET VALUE OF DECENTRALISATION
Authors: Brigida Matt
Published: September 2023

A prominent motivation for the use of cryptocurrencies is the system of exchange does not require a central trusted authority. In fact there are a class of decentralised exchanges where participants can exchange cryptocurrencies using a protocol rather than a centralized exchange. This analysis uses the failure of the centralized FTX exchange to estimate the value the market assigns to decentralised versus centralised exchanges. We find the market assigns a significant value to decentralisation.
Attitude to a Public Institution as an Object of Sociological Analysis
Authors:   Rostov State Economic University (RINH), Tyun Andrey P.
Published: September 2023

The article focuses research attention on the attitude to a public institution as an object of sociological analysis and its significance for clarifying the characteristics of citizens' opinions about various spheres of life in their environment. The author emphasizes the dual function of research in determining the actual problems of so-ciety and formation of goal-setting based on the assessment of the situation in society, as well as in choosing the optimal means of influencing it. The nature of public opinion is considered as a marker of the state of the social sphere and the possibilities of its transformation if necessary. It is emphasized that the perceptions about a particular public institution, fixed in the minds of citizens, determine the specifics of its functioning in society, the success of its implementation of the tasks of its mission. According to the conclusion, the study of public opinion in this direction will allow developing a strategy to correct the situation if necessary.
Features of the Implementation of the Principles of Social Responsibility of Small and Medium-Sized Enterprises
Authors:   Financial university under the Government of the Russian Federation, Shikhgafizov Pirmagomed Sh. , Yeranosyan Vladimir M. ,   Financial university under the Government of the Russian Federation
Published: September 2023

The relevance of the work is due to the presence of many factors that influence the process of implementing the principles of social responsibility of small and medium-sized businesses. There are a certain number of drivers for the development of social responsibility of business, characteristic of small and medium-sized en-terprises. The aim of the study is to analyze the peculiarities of the implementation of the principles of social responsibility of small and medium-sized enterprises. Thin the framework of the theoretical part of the imple-mented research, the works of both domestic and foreign researchers were analyzed, whose scientific interests were formed around the peculiarities of the implementation of social responsibility of small and medium-sized enterprises. Especially noteworthy are the works of R. Turnaev, A. Vavilina, V. Lukashevich, N. Vovchenko, O. Andreeva, M. Izmailova, and others. Also, as part of the analysis of secondary data, a comparative analysis of the research results of scientists in the field of the specifics of social responsibility of small and medium-sized enterprises was carried out. An expert survey was also conducted as part of the study (n = 27). The key drivers of the development of social responsibility of small and medium-sized enterprises are considered, their role in the development of the concept of social efficiency is revealed. Conclusion dwells upon the fact that the inte-gration of the principles of social responsibility in the activities of small and medium-sized enterprises is one of the most important components determining its development in the context of actualization of the sustainable development agenda.
Contemporary Digital Communications and Their Impact on Building Personal Relationships
Authors:   All-Russian Scientific-Research Institute of Mineral Raw Materials named after N.M. Fedorovsky, Yakushina Olga I.
Published: September 2023

The article examines a new sociological problem related to the role and place of remote information and communication technologies (ICT), digital means of communication in interpersonal relations, their impact on the individual and changes in society as a whole. The object of the study is interpersonal relations implemented through the use of digital technologies and mobile devices. The analysis of the conceptual provisions of mod-ern theories of society on the prerequisites and causes of the transformation of interpersonal relationships and the phenomenon of intimacy in the transition and wide distribution of communication through mobile devices is presented. New digital forms of interpersonal communication such as online dating, ghosting are character-ized. The use of ICT, especially mobile devices (gadgets) and the transition of online dating to a mobile plane with the help of various digital applications in social networks, has led to disappearance of the boundary be-tween real and virtual space is becoming much more blurred, and the level of certainty in the environment is decreasing in social space and in personal relationships for both the initiator and the recipient of communica-tion. The easiness to contact with potential romantic partners breeds a lower commitment to maintaining the relationship. If in the real world there are always doubts, then the Internet space offers an infinite number of partners who are definitely open to acquaintances and communication. Therefore, the rupture of digital rela-tions occurs without explanation, simply interrupting communication, there is no need for efforts to end the rela-tionship. Conclusion dwells upon the fact that, despite the obvious advantages of using modern ICT in every-day life, the simplicity and lightning speed of establishing contact, the multiplicity of choices lead to psychologi-cal strain, to the problem of long-term preservation of close relations between partners. A sense of loneliness among people in the modern world arises and grows, posing a threat to the society’s well-being as a whole.