bluuebunny/crossref_metadata_2025 huggingface dataset:
Lysophosphatidic Acid Receptor 6: A Prognostic Biomarker for Lung Adenocarcinoma via Correlating Immune Infiltration
Authors: He Jian , Meng Mei , Wang Hui
Published: July 2021

Background

LPAR6 is the most recently determined GPCR of LPA, and very few of study have demonstrated the performance of LPAR6 in cancers. Moreover, the relationship of LPAR6 to prognosis potential and tumor infiltration immune cells in different cancers still unclarified.
Methods

The mRNA expression of LPAR6 and its clinical characteristics were evaluated on various databases. The association between LPAR6 and immune infiltrates of various types of cancer were investigated via TIMER. IHC for LPAR6 in LUAD and LUSC tissue microarray with patients’ information was detected.
Results

We constructed a systematic prognostic landscape in various types of cancer base on the mRNA expression level. We enclosed that higher LPAR6 expression level was associated with better OS in some types of malignancy. Moreover, LPAR6 significantly affects the prognostic potential of various cancers in TCGA, especially in lung cancer. Tissue microarray’s results demonstrated that higher protein level of LPAR6 was correlated with better overall survival of LUAD rather than LUSC cohorts. Further research found that the underlying mechanism of this phenome might be the expression level of LPAR6 was positively associated with infiltrating statuses of devious immunocytes in LUAD rather than in LUSC, that is, LPAR6 expression potentially contributes to the activation and recruiting of CD8 + T, naive T, effector T cell and natural killer cell and inactivates Tregs, decrease T cell exhaustion and regulate T-helper cells in LUAD.
Conclusions

Our discovery implies that LPAR6 is associated with prognostic potential and immune-infiltrating levels in LUAD. These discoveries imply that LPAR6 could be a promising biomarker for indicating prognosis potential and immune infiltration level in LUAD cohorts.
Drug-Handling Problems and Expectations of the Ideal Pediatric Drug — Reported by Children and Their Parents
Authors: Herziger Birthe , Jeschke Sarah , Müller Ruth Melinda , Neininger Martina Patrizia , Bertsche Thilo , Bertsche Astrid
Published: July 2021

Experienced drug-handling problems and inadequately considered expectations for drug therapy have an unfavorable influence on therapy. We performed a questionnaire survey in (i) parents of 0–5-year-old children and (ii) 6–17-year-olds and their parents. We assessed (A) experienced drug-handling problems and (B) expectations for drug therapy. (i) 46 parents and (ii) 103 children and their parents participated in the study. Experienced drug-handling problems were described by (i) 100% of parents and (ii) 62% of children and 70% of parents. Problems concerned the preparation of the drug, dosing, compliance with the time interval, and acceptance. (i) 65% of parents preferred a peroral route of drug administration, while (ii) 74% of children and 86% of parents did so. Preferred characteristics of peroral drug formulations, e.g. liquid versus solid drug formulations or flavor, were highly heterogeneous. Preferences of 6–17-year-old children and their parents matched in 43% to 66%. Conclusion: Most children and their parents had already experienced drug-handling problems. Preferences concerning the ideal pediatric drug were highly heterogeneous and in about half of cases, preferences of children and their parents differed. Thus, the children should be approached directly. If information is solely gained from parents, the children’s needs might remain unmet.
De-implementing Low-Value Care in Cancer Care Delivery: A Systematic Review
Authors: Tabriz Amir Alishahi , Turner Kea , Clary Alecia , Hong Young-Rock , Nguyen Oliver T , Wei Grace , Carlson Rebecca , Birken Sarah A
Published: July 2021

Background

Accumulating evidence suggests that interventions to de-implement low-value services are urgently needed. While medical societies and educational campaigns such as Choosing Wisely have developed several guidelines and recommendations pertaining to low-value care, little is known about interventions that exist to de-implement low-value care in oncology settings. We conducted this review to summarize the literature on interventions to de-implement low-value care in oncology settings, define an agenda for future research, and inform the literature about opportunities for additional work.
Methods

We systematically reviewed the published literature in PubMed, Embase, CINAHL Plus, and Scopus. We screened the retrieved abstracts for eligibility against inclusion criteria and conducted a full-text review of all eligible studies on de-implementation interventions in cancer care delivery. We used the framework analysis approach to summarize included studies' key characteristics including design; outcome(s); type of cancer, objective(s); and de-implementation interventions, determinants of the use ofthe use of de-implementation interventions, and their effectiveness. We assessed included studies’ quality using the NIH Quality Assessment Tools.
Results

Out of 2,793 studies, 13 met our inclusion criteria. Included studies have been published between 2003 and 2020, and the majority (n = 9) of them were conducted in the USA. They covered several cancer types including prostate cancer (n = 4), multiple cancers (n = 3), hematologic cancers (n = 3), lung cancer (n = 1), breast cancer (n = 1), and gastrointestinal cancer (n = 1). Four studies were focused on de-implementing low-value diagnostic tests, six studies focused on de-implementing low-value treatment procedures, and three studies focused on low-value screening services. Most of the de-implementation interventions (n = 11) were effective in reducing low-value care. No study assessed the determinants of the use of de-implementation interventions.
Conclusions

This review showed that to accelerate the reduction of low-value cancer care, instead of solely relying on diffusion new evidence and guidelines (i.e., passive de-implementation), healthcare organizations should initiate de-implementation interventions and implement strategies purposefully aimed at reducing low-value care (i.e., active de-implementation). Additionally, future research should include a broader range of variables such as patients’ perspectives and preferences, unintended effects of de-implementing low-value care, and system-level factors when studying de-implementation.
Analysis of Risk Factors for Perioperative Hidden Blood Loss in Unilateral Biportal Endoscopic Spine Surgery: A Retrospective Multicenter Study
Authors: Wang Haosheng , Wang Kai , Lv Bin , Li Wenle , Fan Tingting , Zhao Jianwu , Kang Mingyang , Dong Rongpeng , Qu Yang
Published: July 2021

Background

Hidden blood loss (HBL) represents an important complication of unilateral biportal endoscopic (UBE) spine surgery. This study aimed to evaluate HBL and it’s possible risk factors among patients undergoing UBE surgery for lumbar degenerative diseases.
Methods

This multicentric retrospective study was conducted in 3 different medical centers between July 2020 and April 2021. Data of patients underwent UBE surgery were extracted by electronic medical record system. The patient’s demographic characteristics and blood loss-related parameters were recorded. We calculated the amount of HBL and explored the association between patient’s characteristics and HBL using Pearson or Spearman correlation analysis. Multivariate linear regression analysis was conducted to identity independent risk factors of HBL.
Results

A total of 136 patients (55 females and 81 males, age range 43 to 74 years) were included in this study. A substantial amount of HBL (469.5 ± 195.3 ml, 57.6 % of TBL, total blood loss) occurred following UBE surgery. Multiple linear regression analysis indicated that the risk factors of HBL were as follows: age (P = 0.000), number of fusion levels (P = 0.015), American Society of Anesthesiologists (ASA) classification (P = 0.046), surgery time (P = 0.017), patient’s blood volume (PBV, P = 0.026), total blood loss (TBL, P = 0.001), postoperative (i.e., day 2 or 3) hematocrit(Hct, P = 0.034), Hct loss (P = 0.005), and fibrinogen (P = 0.028).
Conclusions

A certain amount of HBL occurs in UBE surgery and cannot be ignored in daily clinical practice. The age, number of fusion levels, ASA classification, surgery time, PBV, TBL, postoperative Hct, Hct loss, and fibrinogen are independent risk factors for HBL.
Association of Anxiety With Sperm Quality: a Multicentre Cross-sectional Study in China During the COVID-19 Outbreak
Authors: Wang Yongfeng , He Liting , Yang Yunyi , Tu Lihui , Yang Jigao , Zhang Zhou , Meng Tianqing , Jiang Xianglong , Zhu Wenbing , Li Yushan , Zhang Huiping , Zhao Kai , Zhang Xinzong , Liu Chunyan
Published: July 2021

Objectives: There is no report about association of anxiety on sperm quality during the COVID-19 epidemic. Purpose of this study was to investigate the relationship between anxiety and sperm quality during the COVID-19 outbreak in China.Methods: 896 sperm donors from 7 sperm banks in China were investigated, and passed the screening for sperm donation between 23 January 2020 and 8 June 2020. Semen quality analysis follows the standards of the WHO Fifth Edition Human Semen Examination and Processing Manual. Anxiety symptoms were assessed by the Generalized Anxiety Disorder Scal-7(GAD-7). Logistic regression and linear regression were used to identify the association between anxiety level and sperm quality.Results: Participants with anxiety status (N = 155; 17.3%) had lower sperm concentration (56.81 ± 32.70 vs. 47.21 ± 30.76 [106/mL]), sperm volume (3.58 ± 1.65 vs. 3.04 ± 1.69 [mL], P < 0.001), total sperm count (7.29 ± 1.23 vs. 6.56 ± 1.63 [106], P < 0.001), and progressive motility (50.86 ± 12.45 vs. 38.50 ± 17.00 [%], P < 0.001) than those without anxiety. Linear regression showed that anxiety symptoms was significantly associated with 8.13 (95% confidence interval [CI]: 2.51, 13.75), 0.49 (0.20, 0.79) ,51.05 (23.43, 78.68) and 12.15 (95% CI: 23.43, 78.68), reduction in sperm concentration, semen volume, and total sperm count and progressive motility respectively.Conclusions: This study revealed that anxiety symptoms were negatively associated with semen quality, and interaction was discovered between debt stress and anxiety.
Desert Locust Schistocerca gregaria in Rajasthan, India and Establishing an Early Warning System for Locust Control in India
Authors: Jhiknaria Hameer
Published: July 2021

Desert Locust is considered to be the most serious pests that cause a devastated damage to the crops and the other agricultural products during their invasions. The Desert Locust is a major threat for food security, livelihoods, environment and economic development in a region. The recent Locust Outbreak caused major damage to standing crops and vegetables in the Central and Western states of India, including Rajasthan, Punjab, Haryana, and Madhya Pradesh, with Rajasthan being the most affected. India had experienced such massive locust invasion after two decades. Establishing an Early Warning System for Locust Control in India is essential to reduce the impact by providing timely and relevant information in a systematic way contributing to increasing in resilience of the country. The distribution of Desert Locusts in Rajasthan, India has been presented from June 2019 to August 2020, along with the key Environmental Factors of Temperature, Rainfall, Soil Moisture and Prevalence of Vegetation significantly affecting Locust Activity. All the datasets used were obtained from Secondary sources. These datasets were obtained from Open Government Data (OGD) Platform. The Maps created in the study show the Distribution of Desert Locusts in Rajasthan, India; along with this the Choropleth map show Average- Temperature, Rainfall, Soil Moisture and Normalized Difference Vegetation Index (NDVI), all at District level. The Early Warning System for Desert Locust Control in India is a key integration of four key elements of: Risk Knowledge, Monitoring and Warning Service, Dissemination and Communication and Response Capability, and four-four sub elements of each key element. Establishing an Early Warning System for Locust Control in India is of paramount importance.
Effects of Early Estradiol Valerate Administration On Bone Turnover Markers in Surgically Induced Menopausal Women
Authors: Vatrasresth Jarika , Suwan Ammarin , Panyakhamlerd Krasean
Published: July 2021

Background

Compared with natural process, surgically induced menopausal women have a higher bone loss rate. The objectives of this study were to evaluate effects of early treatment with estradiol valerate on the bone turnover markers levels after surgically induced menopause.
Methods

This prospective study enrolled 48 pre and perimenopausal women who underwent hysterectomy with oophorectomy for benign gynecologic conditions. Two weeks after surgery, all participants were assessed for menopausal hormone therapy (MHT) indications. Estrogen therapy was prescribed for those who had indication and accepted treatment (hormone treatment group). The others who had no MHT indication were allocated to no treatment group. Serum CTX and P1NP levels were measured at preoperative and 12 weeks postoperative.
Results

The median serum CTX and P1NP at 12 weeks were significantly different between two groups (p-value < 0.001 and 0.004, respectively). Median serum CTX and P1NP levels of women in the hormone treatment group were 55% and 40% lower than the women in no treatment group, respectively. At 12 weeks after surgery, serum CTX and P1NP levels were significantly elevated among women who did not receive hormone treatment (p-value < 0.001 and 0.002). In contrast, there were no significant change in the hormone treatment group.
Conclusion

Surgically induced menopausal women who received early estradiol valerate therapy had significantly lower levels of serum CTX and serum P1NP compared to women who did not receive treatment at 12 weeks after surgeries. This indicated that early estradiol valerate treatment could significantly suppress high bone-remodeling process in women with acute estrogen deprivation conditions.
Trial registration:

Thai Clinical Trial Registry identification number TCTR20190808004, retrospective registered since 2019-08-08. http://www.thaiclinicaltrials.org/show/TCTR20190808004
Scarless genome editing reveals risk SNP rs6983267-G and lncRNA CCAT2 dictate targetable PI3K signaling dependence in WNT-dysregulated CRC
Authors: Coggins Nicole B. , O’Geen Henriette , Lott Paul C. , Segal David J. , Carmona Luis Carvajal
Published: July 2021

Genome-wide association studies have identified numerous loci associated with increased risk for colorectal cancer (CRC), including 8q24.21 which contains a known enhancer of proto-oncogene MYC . However, the role of candidate functional SNP rs6983267 within this locus remains unclear. Here, we generate isogenic cellular models of risk SNP rs6983267 in human CRC line, HCT-116. Comprehensive molecular characterization reveals risk allele-G drives enhancer DNA contacts with downstream regions that include MYC . Absence of risk allele leads to activation of lncRNA CCAT2 . Rather than changes in MYC expression, we observe activation of alternative growth factor signaling pathways with loss of both risk allele and CCAT2 expression. Analysis of TCGA CRC cases demonstrates low CCAT2 expression combined with non-risk rs6983267 genotype correlate with higher frequency of PI3K mutations in CRC patients displaying WNT dysregulation. Together, these provide a potential biomarker for therapeutically targetable PI3K dysregulation in CRC and application in cancer precision medicine.
Restless Rainbows And Bold Browns: Personality of Domesticated Trout Predicts Invasiveness And Impact
Authors: McGlade Ciara L. O. , Dickey James W. E. , Kennedy Richard , Donnelly Shannon , Nelson Clare-Ann , Dick Jaimie T. A. , Arnott Gareth
Published: July 2021

Personality and behavioural syndromes are increasingly recognised in many animal species and are now seen as critical to the prediction of non-native species success and impacts. Rainbow trout and brown trout have been introduced globally, but differ in patterns of establishment success and ecological impact. While environmental tolerance may be a driver, thus far the role of behaviour has not been rigorously tested. Here, we investigated whether diploid rainbow trout and diploid and triploid brown trout differ among several key behavioural measures linked to invasibility. We assessed activity, boldness, aggression, and feeding, using open field, novel object, shelter, mirror, feeding, and functional response experiments. We also tested within each fish type for behavioural syndromes comprising correlations among activity, boldness and aggression. Rainbow trout were more active and aggressive but less bold than diploid and triploid brown trout. In small groups, however, rainbow trout were bolder than both types of brown trout. Diploid brown trout were more active and bolder than triploids when tested individually. There was no association between activity and boldness in rainbow trout, but there was in both brown trout. The increased activity and aggression of rainbow trout may reflect an increased stress response to novel situations, with this response reduced in a group. These results suggest that rainbow trout do not manage their energy budgets effectively, and may explain why they are implicated in fewer ecological impacts. Comparative analyses of multiple behaviours of invasive species and genetic variants may thus be key to understanding and predicting invader success and ecological impacts.
Curved Interference Patterns---Novel Double Slit and Cross-double Slit Experiments (2)
Authors: Peng Hui
Published: July 2021

Young’s double slit experiments represent the mystery of quantum mechanics. To explore the mystery, varieties of the double slit and cross-double slit experiments were performed. In this article, we show novel phenomena that the interference patterns of the double slit/cross-double slit experiments can be curved. The curvatures depend on the orientation of the diaphragms of the double slit/cross-double slit. Those experiments provide comprehensive data for developing/testing a theoretical model.
Anais II Simpósio Científico da Área da Saúde da Universidade Brasil
Authors: Simonato Luciana Estevam , Melo Elizabete Santos , Mininel Francisco José , Jesus Giselle Juliana de , Lopes Leandro Teixeira Paranhos , Silva Milena Milena Carla Queiroz da , Boer Nagib Pezati , Franqueiro Nicezia Vilela Junqueira , Silva Wagner Rafael da
Published: July 2021

Editorial

Caro(a) Leitor(a),

A Universidade Brasil - Campus Fernandópolis vivenciou nos dias 7 e 8 de dezembro de 2020 o II Simpósio Científico da Área da Saúde, que foi idealizado com o intuito de os alunos dos diversos cursos da área da saúde do Campus Fernandópolis pudessem participar apresentando trabalhos científicos, tais como: Biomedicina, Educação Física, Enfermagem, Farmácia, Fisioterapia, Medicina, Medicina Veterinária, Nutrição e Odontologia. Nesta segunda edição, foram inscritos 139 trabalhos nas áreas de Biomedicina, Enfermagem, Farmácia e Odontologia, distribuídos nas modalidades Pesquisa Científica, Caso Clínico e Revisão de Literatura.

Convido todos vocês para que desfrutem deste momento, esperando que aproveitem ao máximo os ensinamentos que serão transmitidos. Importante lembrar que neste mundo globalizado e competitivo não há como crescer profissionalmente sem agregar novos conhecimentos. Todos os dias!!!

Obrigada, sejam bem-vindos,

Profa. Drª. Luciana Estevam Simonato

Presidente - II Simpósio Científico da Área da Saúde da Universidade Brasil - Campus Fernandópolis/2020
Computer-Based Simulation by Emergency Medicine Resident-Educator for Medical Students during the COVID-19 Pandemic
Authors: Ho Shu Fang , Tan Ming Jing Elizabeth , Lateef Fatimah
Published: July 2021

Today, residents in all disciplines are expected to be involved in not just educating themselves but in the education of others and peers as well. They are involved in a wide spectrum of teaching and instruction techniques such as case presentations, lectures, practical hands-on teaching, bedside clinical tutorials, informal discussions and simulation-based training. Simulation-based teaching has been playing an increasingly important role in both residency training as well as medical school curricula. In particular, it appeals to adult learners as it very task-driven and task-oriented, it allows for constant active engagement during role-playing in simulated scenarios and enables repetitive practice until a certain level of mastery or competency is achieved. The SingHealth residents training in emergency medicine have been collaborating with and engaging medical students from the Duke-NUS Graduate Medical School, as the two entities for a common Academic Medical Center. They share many collaborative projects and activities, research as well as educational training programmes. However, with the recent COVID-19 pandemic, both face-to-face medical teaching as well as simulation-based teaching proved to be challenging. One alternative is to move these teaching collaborations and programmes onto the online platform. This study describes the experience of emergency medicine resident-educators who conducted emergency medicine computer-based simulations (CBS) in collaboration with a group of medical students from the Duke-NUS Emergency Medicine Student Interest Group during the COVID-19 pandemic.
Exposure to Domestic Violence During the COVID-19 Pandemic: A Potent Threat to the Mental Well-being of Children
Authors: Woi Hon Boo
Published: July 2021

The unprecedented scale of the coronavirus disease 2019 (COVID-19) pandemic has indeed brought about tremendous ramifications on the state of mental health for children. One notable aspect deserving emphasis however, is the psychological impact in children as a result of the purported surge of domestic violence (DV) in many of the countries that imposed stay-at-home requirement. The imposition of movement restriction policy led to isolation and overcrowding, made worse by loss of income in some instances, causing high levels of stress and anxiety, thereby increasing the risk of DV and child abuse particularly those already living within violent or dysfunctional families. Children exposed to DV have higher risk of developmental delay and behavioural problems, more likely to suffer from post-traumatic symptoms, depression and anxiety, reduced cognitive functioning and social competence. Additionally, these children tend to have poorer academic performance and are more likely to engage in violent or abusive relationship later in life. Health care providers need to be vigilant and actively screen and identify children or families that are affected by DV to protect their physical and mental health well-being.
Comparison of 3D Hip Joint Kinematics in People with Asymptomatic Pronation of the Foot and Non-Pronation Controls
Authors: Alahmri Fayez , Alsaadi Saad , Ahsan Mohammed
Published: July 2021

Background: The impact of asymptomatic pronation on proximal joints during motion has not been well understood, and research on it remains limited. Therefore, the current study determines the effect of asymptomatic pronation of the foot on hip joint kinematics during gait.
Methods: Forty participants were recruited for the study (20 with asymptomatic pronated feet and 20 with non-pronated feet). Foot assessment was conducted by navicular drop and rear- foot angle tests. Hip joint kinematics were measured via MVN Xsens system 3D-motion capture from sagittal, frontal and transverse planes during gait. An independent t-test was used to identify differences in kinematic variables.
Results: Both groups were similar in characteristics, and there were no significant differences between the groups in age (P = 0.674) and BMI (P = 0.459). However, there was a significant difference in arch height (P = 0.001) and rear-foot angle (P = 0.001). Our findings showed there were insignificant differences between the asymptomatic pronated foot and non- pronated foot control groups in hip joint kinematics of sagittal (P = 0.618), frontal (P = 0.276), and transverse (P = 0.337) planes during a full gait cycle.
Conclusion: Patients with asymptomatic pronation of the foot and non-pronation of the foot showed similar movement patterns of hip kinematics in all three planes. The findings of the present study highlight the need for clinicians to consider foot alignment when examining patients with asymptomatic pronation of the foot and non-pronation of the foot.
Pink Pigmented Facultative Methylotrophic Bacteria Isolated from Fermented Philippine Shrimp Paste
Authors: Christian Jordan O. dela Rosa  , Anthony C. Lee  , Windell L. Rivera
Published: July 2021

Pink pigmented facultative methylotrophic (PPFM) bacteria are ecologically distributed microorganisms. They have been isolated in many types of ecosystems like soil, water, air, in association with plants and even as pathogens in humans. However, a yet unexplored area for PPFM bacteria research is in food. Hence, the objective of this study was to establish the presence of PPFM bacteria in Philippine fermented food, in particular shrimp paste, and characterise them phenotypically and genotypically. A total of 13 PPFM bacteria were obtained from Philippine shrimp paste. Sequencing of the 16S rRNA gene revealed that the PPFM bacterial isolates belong to the genus Methylobacterium. A total of 35 phenotypic characterisations were performed that included morphological, biochemical and physiological tests. Phylogenetic tree was constructed to establish the genetic relatedness of the isolates. Morphological test results showed that all 13 isolates were consistent with the established phenotypic characters of the genus such as pink colony colour, Gram negative and rod-shaped. Biochemically, the use of API® 20 NE tests showed heterogeneity of results and physiological tests exhibited that the isolates are primarily mesophilic and halotolerant, being able to grow at 2% salt. Phylogenetic analysis showed that the isolates are Methylobacterium populi, M. dankookense, M. lusitanum, M. radiotolerans and M. zatmanii. This study confirmed the presence and diversity of PPFM bacteria in Philippine shrimp paste. Further studies are needed to show the functional activity of Methylobacterium in Philippine shrimp paste production.
Immunomodulatory Effects of Asiaticoside Against Shigella flexneri-Infected Macrophages
Authors: Michael Shalini , Zakaria Nor Munirah , Abbas Muhammad Adamu , Abdullah Hasmah , Suppean Rapeah
Published: July 2021

Macrophages provide the first line of defense against Shigella flexneri infection in the gastrointestinal tract by inducing a variety of inflammatory and antimicrobial responses. Secondary metabolites of plants are used as drugs against infections that are resistant to common antibiotics. In this study, the innate effects of asiaticoside on the proinflammatory activity of mouse macrophages infected with S. flexneri were investigated. The viability of the infected mouse macrophages were examined using viability assay, while the pro-inflammatory cytokines productions were determined using the enzyme-linked immunosorbent assay (ELISA) for determination of IL-1β, IL-12 p40 and TNF-α levels. The production of nitric oxide (NO) and the expression of inducible nitric oxide synthase (iNOS) protein were determined using the Griess assay and western blot, respectively. Statistical analyses were performed using the Statistical Package of Social Sciences (SPSS) software, version 20. The data obtained from independent experiments (n = 3) were presented as the mean ± standard error of mean (SEM). The results showed that, asiaticoside stimulated the infected macrophages by stimulating increased production of TNF-α, IL-12 p40 and NO as well as increased expression of iNOS in a dose-dependent manner. In contrast the viability of the cells and the production of IL-1β and were reduced also in a dose-dependent manner when compared to untreated cells. These results indicate that asiaticoside has immunomodulatory effects on the innate immune function of infected macrophages, showing the potential use of this compound to reduce the clinical symptoms of the infections.
Scale Structure and Reflectance Activity of Metapocyrtus apoensis
with Notes on Its Distribution in Mindanao, the Philippines
Authors: Patano Jr. Romeo R. , Abales Joriegae M. , Bajuyo Erika J. , Magtulis Ara Belle R. , Mendez Rainear A. , Hinampas Rhesa T.
Published: July 2021

Scale structure and reflectance activity of a Mindanao endemic weevil from the genus Metapocyrtus has been studied for the first time. Specimens of Metapocyrtus apoensis Schultze, 1925 were collected through opportunistic sampling in Mount Calayo, Musuan, Mindanao, Philippines last February 2020. A total of three individuals of the species were collected all in lower dipterocarp forest with elevation of 500 masl–600 masl. Three specimens were then examined under Scanning Electron Microscopy with Energy Dispersive X-Ray (SEM_EDX) to analyse its scale structures and reflectance activity. The study provides new locality record of the Mindanao endemic species first in Bukidnon region and an updated distribution in Mindanao based on recent published articles and museum collections. The species inhabits wide ranges of habitat types that greatly differ in elevation and vegetation. Examination of scale’s structure through SEM revealed that M. apoensis scales are 50 μm–70 μm in diameter which are almost circular in shape, slightly convex with rough like surface which is termed as non-ordered nipple-like structure. The scales’ shape and surface structure clearly differ from other genera of curculionids based on published articles. Analysis of the particles on the weevil’s elytra done by EDX reveals several elements that contribute to its iridescence. Major elements such as carbon (42.3%), oxygen (27.7%) and nitrogen (15.1%) come in relatively high atomic concentrations. Microspectrometer revealed a peak reflectance wavelength of about 569.7 nm. This explains the yellow-green iridescence observed on the dorsal side of the weevil. The concentration of the scale in pits serves for protection, intraspecific recognition and camouflage. Despite of widespread distribution and high abundance of this species in Mindanao, anthropogenic disturbances such as agricultural activities are on-going which extend towards their microhabitat. Monitoring to its population is recommended as the species is restricted only in Mindanao.
New Mineral Names,
Authors: Belakovskiy Dmitriy I. , Uvarova Yulia
Published: July 2021

In this issue

This New Mineral Names has entries for 10 new species, including huenite, laverovite, pandoraite-Ba, pandoraite-Ca, and six new species of pyrochlore supergroup: cesiokenomicrolite, hydrokenopyrochlore, hydroxyplumbopyrochlore, kenoplumbomicrolite, oxybismutomicrolite, and oxycalciomicrolite.
Effect of Persulfates on Production of Carotenoids in the Rhodosporidium sphaerocarpum, R. diobovatum and Rhodotorula glutinis Yeast Cultures
Authors: Delegan Ya.A. , Antipova T.V. , Vainshtein M.B.
Published: July 2021

The methods for increasing the isolation of carotenoids from yeast producer cultures have been compared. It was shown that the optimal procedure is microwave pretreatment (2450 GHz, 600 W, 40 s) with subsequent extraction of the target products with methanol. Additives of sodium persulfate or ammonium persulfate to aerated culture medium provided additional oxygen sources for the yeast and increased the medium redox potential. The introduction of persulfate led to a 1.3-fold increase in the content of colored carotenoids in the R. dubiovatum VKPM Y-305 biomass as compared to the control without persulfate. In the R. sphaerocarpum VKPM Y-1559 biomass, persulfate at concentrations of 0.15 g/L and 0.50 g/L increased the content of colored carotenoids by 1.3 and 1.4 times, respectively. The optimal persulfate concentent depends on the yeast growth phase and time of exposure to the compound. Higher persulfate concentrations resulted in increased redox potential and discoloration of carotenoids, though without yeast cell death.

yeasts, carotenoids, medium redox potential, persulfate
Análisis sistemático sobre el uso de la Realidad aumentada en Educación Infantil.
Authors: Rivas Rebaque Begoña , Gértrudix Barrio Felipe , Gértrudix-Barrio Manuel
Published: July 2021

El informe Horizon 2019 situaba el aprendizaje móvil como una tecnología a ser adoptada en Educación Superior a corto plazo y tenía en cuenta la realidad aumentada (RA) como tendencia a medio plazo. Si estas tecnologías avanzadas están presentes en cualquier ámbito de nuestra vida diaria sin distinción de edades, límites o escenarios ¿Por qué no extender también su práctica en el entorno educativo de edades tempranas?  Así, este estudio sobre RA tiene como finalidad 1) revisar si esta evolución ha sido positiva; 2) indagar sobre las metodologías y estrategias en el uso de la RA en la etapa de Educación Infantil; y 3) explorar si existen limitaciones a la hora de utilizar este tipo de tecnología en edades tempranas como recurso didáctico. El método ha sido la revisión sistemática de 49 documentos (entre artículos y papers) publicados de enero de 2011 a abril de 2021, en la base de WOS (SSCI), siguiendo los criterios de PRISMA. Los hallazgos extraídos sintetizan las tipologías de análisis de datos que se llevan a cabo, los diferentes usos que se efectúan con realidad aumentada y las diferentes conclusiones que se extraen de esas experiencias.
Bahrul Lahut Manuscripts in East Java: Study of Philology and Reconstruction of Tarekat Networks
Authors: Mashuri Mashuri
Published: July 2021

This research discusses the manuscript of Bahrul Lahut with the approach of philology, geneo-archeology of knowledge, and history. The aim was to study the text of Bahrul Lahut, its contents, and trace the Aceh-Makassar-East Java tarekat network based on the distribution of the manuscripts. As the result, (1) there are three existences of Bahrul Lahut in East Java, namely the Traditional Islamic Boarding School (Pondok Pesantren) of Sumber Anyar, Pamekasan, Madura, the EDR’s collection in Sidoarjo, and Jamaah Tarekat Satariyah in Pare Kediri, (2) Text edition is selected from the collection of Pondok Pesantren Sumber Anyar with philology consideration, (3) The Bahrul Lahut manuscript is only available in the manuscript catalog of Dayah Tano Abee, Aceh, and the collection of the family of Yusuf Makassar, (4) The text content of Bahrul Lahut describes and re-reads the conception of the nature of God and the creation of the universe as a manifestation of Nur Muhammad, influenced by wahdat al-wujud and emanation of Ibn Arabi, (5) From the Bahrul Lahut manuscript, a network of tarekat ulama in East Java can be reconstructed, through the paths of Abdurrouf Singkel and Yusuf Makassar.
Poesia e composição: considerações sobre uma das “teses” de João Cabral de Melo Neto
Authors: Caldeira Rodrigo
Published: July 2021

Mais conhecido por sua obra poética, João Cabral de Melo Neto (1920-1999) é, também, autor de um valioso material crítico em prosa que, desde a primeira reunião em 1997, tem despertado interesse e contribuído para uma melhor compreensão do seu projeto literário. Destas “teses” — como o próprio autor se referia a alguns desses trabalhos — destacam os três primeiros: “Considerações sobre o poeta dormindo” (1941), “Joan Miró” (1950) e “Poesia e composição” (1952).   O propósito deste artigo é, portanto, apresentar algumas considerações acerca do pensamento crítico desenvolvido por Cabral no texto “Poesia e composição”, destacando os conceitos originais de “poetas fáceis” e de “poetas difíceis” desenvolvidos pelo autor de modo a contribuir para as discussões sobre este tema. Apoiam esta leitura os trabalhos de Lima (2002), Carvalho (2009), Siscar (2018) e Pessôa (2019).
Advantages, Marketed Formulations and Evaluation Parameters of SMEDDS
Authors: Kaushik Deepak , Verma Ravinder , Mittal Vineet , Purohit Deepika
Published: July 2021

Various applications of SMEDDS are discussed in detail in this chapter,
which include: upgrading the solubility and bioavailability, protection against
biodegradation, effortless production and scale-up, diminishment in inter-subject and
intra-subject inconstancy and food impacts, the capability to convey peptides that are
liable to enzymatic hydrolysis in GIT, no impact on the lipid digestion and
improvement in drug loading capability. Different variables affecting the performance
of SMEDDS formulation are the nature, amount of the drug, polarity of the lipophilic
phase, and a charge on a droplet of emulsion. Globule size, percent transmission, robust
dilution, zeta potential measurement, cloud point estimation, stability studies, in vitro
lipolysis, in vitro drug release assessment, permeability study, etc., are various
evaluation parameters for SMEDDS/LBDDS that are discussed briefly. This chapter
highlights various advantages, evaluation parameters, and marketed products related to
SMEDDS.
FACTORS AFFECTING BLIND STUDENTS’ ENGAGEMENT IN LEARNING ENGLISH
Authors: Nurul Indah Asri Galuh , Adrianto Firdaus Adrianto
Published: July 2021

Universitas Brawijaya (UB) with the assistance of Pusat Studi dan Layanan Disabilitas (PSLD) have implemented an inclusive education environment, as the need for equal education chance for different abilities Indonesians. There is an assumption that engagement from a combination of language learning or learning language’s cognitive, social, and affective aspects can affect the learning process and academic achievement of a special need student. To reach the research objective, interview sessions and classroom observations session were aimed at measuring the students' language learning engagement based on three-domains; cognitive, affective and social, in students’ perspective and ongoing activities. This research shows fluctuate results based on the interviews and observations data of two blind students. The main engaged factors found are positive teaching approaches and attitudes, also both students’ learning autonomy.
The Implementation of Guessing Game to Improve The Speaking Ability of EFL Students in Excellent Course, Kampung Inggris, Pare, Kediri
Authors: Tristin Puspitasari Pratiwi
Published: July 2021

Speaking English has been one of the most challenging skill for EFL students to master. Additionally, students should learn vocabulary, grammar, and pronunciation in order to master speaking skill. The fluency and appropriateness of students’ speaking abilities should be improved. Speaking problems are common among students, including a lack of vocabulary, poor grammar and spelling, the last is the use of mother tongue. The researcher distributes a questionnaire to the participants in order to identify the students’ speaking difficulties and overcome them through a joyful Guessing Game technique. The participant in this study were students from Excellent Course, Kampung Inggris, Pare, Kediri, who were in speaking class with various school levels. In conducting this research Classroom Action Research as a method and Guessing Game as a teaching strategy. The study was conducted in a specific class for a week. The total number of the students participating in this study was 45 students, and they are divided into 3 classes in “Improving Speaking Class”. The instruments of this research are pre-test, post-test, speaking rubrics from Hugher (2003:131), and a questionnaire adapted from Ratna S, et al. (2017:33) and Djasminar A, et al (2012). The data was calculated using Ms. Excel. The result of the study shows that only 27% students succeed in doing the pre-test before implementing guessing game. Surprisingly, after guessing game was implemented the number has increased into 62% of the students proven to be a success in the post-test. It is reasonable to conclude that using guessing game to teach speaking is success. Furthermore, the students responded positively to being taught via guessing game and they seemed to enjoy the learning process. The outcome of the students’ perception questionnaire demonstrates this.
The Students’ Opinion on Online Learning
Authors: Suhaimah Sirin , Setyowati Lestari
Published: July 2021

The coronavirus outbreak has impacted all aspects of human life, including the greatest impact is on education. Therefore, the education system that is being carried out conventionally must be converted into online learning to prevent the spread of COVID-19. This article aims to describe (1) the students' opinions regarding English subjects in online learning during the COVID-19 pandemic, (2) the students' difficulties during online learning in English subjects, (3) the students' opinions about understanding the material in English subjects during online learning. This research used a descriptive qualitative design, by using interviews to get the data. The subjects of this study were 2 female and 1 male high achiever students from the first language class in Senior High School 2 situated in the area of a small town Pasuruan, East Java, Indonesia. The research instruments used were mainly personal chats interviews with the subjects of the study. The data collection was conducted in December 2020. The results showed that (1) online learning is less effective, significant, and boring; (2) difficulties that they face are unstable network, difficulty in the delivery of material provided by the teacher, and teacher’s teaching methods; (3) most of them also had difficulty in understanding the materials provided by the teacher.
KARAKTERISTIK SIFAT FISIK TANAH DAN C-ORGANIK PADA PENGGUNAAN LAHAN BERBEDA DI KAWASAN UB FOREST
Authors: Siahaan Renaldy Christian , Kusuma Zaenal
Published: July 2021

UB forest area has various land uses, namely the use of agroforestry land based on coffee and seasonal crops. This will result in various physical properties of the soil in each use, therefore this study aims to determine the physical properties of the soil in different land uses and obtain optimal land use in the UB Forest area. The research was conducted from June to September 2020 in Malang district. The study was conducted on land use of pine forest areas, pine agroforestry + coffee, pine agroforestry + seasonal crops, mahogany agroforestry + coffee and mahogany agroforestry + seasonal crops. The parameters observed included analyzing bulk density, particle density, porosity, available water, water content pF 2.5 and 4.2, hydraulic conductivity, aggregate stability, texture and organic-C. The results showed that land use in the forest area of UB affected the physical soil, namely bulk density, particle density, porosity, hydraulic conductivity, and aggregate stability. Other physical properties, namely soil texture in the UB area. Dominant forest with dusty and clayey clay textures while available water had no significant effect and pine land use is optimal use based on physical properties of soil density, density, aggregate stability and hydraulic conductivity and is supported by the value of organic-C. Soil organic matter in coffee pine land use also has the highest value than other land ranges from 3.44 to 5.07%
EFEKTIVITAS BERBAGAI BAHAN FORMULA PUPUK HAYATI SIANOBAKTERI TERHADAP PERTUMBUHAN DAN HASIL PADI GOGO VARIETAS SITU BAGENDIT
Authors: Eginarta Wahyu Satria , Nuraini Yulia , Purwani Jati
Published: July 2021

Rice is an important commodity in human life where its production increase must be followed by environmental sustainability and land health. The achievement of increased rice production supported by environmental sustainability can be achieved by utilizing biological fertilizers. One of the microbes that can be used as nutrient providers for rice plants is cyanobacteria. This study was carried out in a greenhouse and soil biology laboratory of the Indonesian Soil Research Institute using a randomized block design with four replications. The treatments tested consisted of F0 (without treatment), F1 (wet cyanobacteria isolate), F2 (dry cyanobacteria isolate), F3 (cyanobacteria + rock phosphate), F4 (cyanobacteria + biochar), F5 (cyanobacteria + kaolin), F6 (cyanobacteria + rock phosphate + kaolin), F7 (cyanobacteria + rock phosphate + biochar), F8 (cyanobacteria + kaolin + biochar). The results showed that the cyanobacteria formula treatment with biochar (F4) carriers showed the highest total population in the parameters of the cyanobacteria population, bacteria, and fungi so that the interaction was said to be positive. The application of cyanobacteria formula to soil chemistry did not significantly affect the post-harvest soil N, P, and K, while the increase in soil pH occurred in the overall treatment of the cyanobacteria formula. Treatment of cyanobacteria formula with biochar carrier (F4) had significantly different results on parameters of number of tillers, number of panicles, grain weight, number of grains.
ESTIMASI KANDUNGAN FOSFOR PADA TANAMAN NANAS MENGGUNAKAN UNMANNED AERIAL VEHICLE (UAV) DI PT. GREAT GIANT PINEAPPLE, LAMPUNG
Authors: Andika Revaldy , Suntari Retno
Published: July 2021

PT. Great Giant Pineapple (PT. GGP) is the largest pineapple plantation company in Indonesia, with a land area of approximately ±33,000 ha and dominated by soil types in the form of Ultisols. Soil fertility at PT. GGP tends to have relatively low nutrient content, one of which is phosphorus due to Al fixation. The nutrient P in pineapple is used to stimulate root growth, accelerate the ripening of fruit and seeds. Symptoms arising from P deficiency will experience stunted growth (stunted), and the pineapple will become imperfect. This study aimed to estimate the P nutrient content in pineapple plants using vegetation indexes in the form of GNDVI (Green Normalized Difference Vegetation Index). The study was carried out by taking aerial photographs and samples of pineapple plants in the 1 months phase before forcing and 1 months after forcing (F-1 and F+1), laboratory analysis, statistical analysis, and making distribution maps. The results showed that the vegetation index could estimate the nutrient content of P using the best estimation model. This was evidenced from the results of the correlation test which shows a very strong and real relationship of 0.81-0.82 with the regression test results of 66%-67%. In addition, the results of the validation test using the paired t-test showed that the t-count was smaller than the t-table of 2.30, which means that the estimated GNDVI vegetation index and the P nutrient content of pineapple plants showed no significant difference.
PENGARUH APLIKASI KOMPOS KULIT BUAH KOPI TERHADAP KANDUNGAN BAHAN ORGANIK DAN FOSFOR PADA INCEPTISOL KEBUN KOPI DESA BANGELAN, MALANG
Authors: Risdawati Nadiya , Soemarno S
Published: July 2021

High coffee production rates result in an increase in coffee waste, especially on the skin, which has not been used optimally. Inside the skin of the coffee fruit, there is 45.3% organic matter, 2.98% nitrogen, 0.18% phosphorus, and 2.26% potassium content which has the potential to be used as compost. The soil used in this research is Inceptisol soil type obtained from PTPN XII Bangelan Coffee Plantation, Malang. Inceptisol soil in this land has several problems, such as low soil fertility due to intensive use and improper fertilizer management. The use of compost can increase nutrient content and increase the pH value of the soil. This research was done in three different places at PTPN XII Bangelan for taking samples, Agriculture Faculty of Brawijaya University, especially in Soil Biology and Chemistry Laboratory for the incubation process and analysis of soil chemical characteristics. This research used a completely randomized factorial design with nine treatments and three replications. The nine treatments consisted of different soil depth such as (0 - 20 cm, 20 - 40 cm, and 40 - 60 cm) and three different dosages. The results showed that the application of coffee peel residue to soil significantly affected organic matters (organic-C) and phosphorus. For organic matters, soil depth that consisted most of it was 0 – 20 cm (topsoil), and the fertilizer dosage that consisted most of it was dosage 0.58 g ha-1 and 1.16 g ha-1.