bluuebunny/crossref_metadata_2025 huggingface dataset:
Comprehensive Regulation of Liquid–Liquid Phase Separation of Polypeptides
Authors: Wang Yanwei , Xiang Dongxin , Chen Siyuan , Yang Guangcan
Published: September 2023

The elucidation of the molecular driving forces responsible for Liquid–liquid Phase Separation (LLPS) of proteins and nucleic acids within living cells is crucial for understanding its biological functions and its role in related diseases. In the present study, we investigated the regulation of LLPS in a series of polypeptides with repetitive proline and arginine (PR) sequences by modifying their length and the salt concentration in the solution. Our findings indicate that higher salt concentrations are necessary for LLPS of repetitive PR peptides longer than eight PRs, which emerges as a threshold value. To pinpoint the molecular forces driving the LLPS in peptides, we sequentially introduced various concentrations of hydrophobic disruptors, such as 1,6-hexanediol, and electrostatic regulators, such as ethyl alcohol and 6-Aminocaproic acid. We further modulated the electrostatic interaction by introducing ethyl alcohol and 6-Aminocaproic acid to alter the dielectric constant of the solution. The inclusion of ethyl alcohol intensified the electrostatic interaction between arginine molecules, facilitating LLPS of PR15, while 6-Aminocaproic acid yielded the reverse effect. We deduced that the phase separation in peptide systems is conjointly driven by hydrophobicity and electrostatic interactions. These insights can guide the regulation of LLPS in other peptide and protein systems, and could be pivotal in addressing abnormal aggregations of proteins and nucleic acids.
Application of Semiconductor Metal Oxide in Chemiresistive Methane Gas Sensor: Recent Developments and Future Perspectives
Authors: Fu Li , You Shixi , Li Guangjun , Li Xingxing , Fan Zengchang
Published: September 2023

The application of semiconductor metal oxides in chemiresistive methane gas sensors has seen significant progress in recent years, driven by their promising sensitivity, miniaturization potential, and cost-effectiveness. This paper presents a comprehensive review of recent developments and future perspectives in this field. The main findings highlight the advancements in material science, sensor fabrication techniques, and integration methods that have led to enhanced methane-sensing capabilities. Notably, the incorporation of noble metal dopants, nanostructuring, and hybrid materials has significantly improved sensitivity and selectivity. Furthermore, innovative sensor fabrication techniques, such as thin-film deposition and screen printing, have enabled cost-effective and scalable production. The challenges and limitations facing metal oxide-based methane sensors were identified, including issues with sensitivity, selectivity, operating temperature, long-term stability, and response times. To address these challenges, advanced material science techniques were explored, leading to novel metal oxide materials with unique properties. Design improvements, such as integrated heating elements for precise temperature control, were investigated to enhance sensor stability. Additionally, data processing algorithms and machine learning methods were employed to improve selectivity and mitigate baseline drift. The recent developments in semiconductor metal oxide-based chemiresistive methane gas sensors show promising potential for practical applications. The improvements in sensitivity, selectivity, and stability achieved through material innovations and design modifications pave the way for real-world deployment. The integration of machine learning and data processing techniques further enhances the reliability and accuracy of methane detection. However, challenges remain, and future research should focus on overcoming the limitations to fully unlock the capabilities of these sensors. Green manufacturing practices should also be explored to align with increasing environmental consciousness. Overall, the advances in this field open up new opportunities for efficient methane monitoring, leak prevention, and environmental protection.
Polyphenol Profiling by LC QTOF/ESI-MS and Biological Activity of Purple Passion Fruit Epicarp Extract
Authors: Siniawska Monika , Wojdyło Aneta
Published: September 2023

A polyphenolic preparation in the form of the passion fruit epicarp extract was analyzed to identify and quantify the polyphenolic compounds using LC QTOF/ESI-MS and UPLC-PDA-FL. The analyzed parameters included antidiabetic activity (α-amylase, α-glucosidase, and pancreatic lipase), inhibitory activity toward cholinesterase (AChE, BuChE), anti-inflammatory activity (COX-1, COX-2, 15-LOX) and antioxidant activity based on ORAC and ABTS. The polyphenolic preparation of the passion fruit epicarp extract contained 51 polyphenolic compounds representing five groups—flavones (25 compounds; 52% of total polyphenolic), flavonols (8; 16%), flavan-3-ols (6; 7%), phenolic acids (4; 3%), and anthocyanins (7; 21%), with derivatives of luteolin (13 derivatives) and apigenin (8 derivatives) as dominant compounds. The preparation was characterized by an antioxidant activity of 160.7 (ORAC) and 1004.4 mmol Trolox/100 mL (ABTS+o). The inhibitory activity toward α-amylase, α-glucosidase, and pancreatic lipase reached IC50 of 7.99, 12.80, and 0.42, respectively. The inhibition of cholinesterases (IC50) was 18.29 for AChE and 14.22 for BuChE. Anti-inflammatory activity as IC50 was 6.0 for COX-1, 0.9 for COX-2, and 4.9 for 15-LOX. Food enriched with passion fruit epicarp extract has a potentially therapeutic effect.
Synthesis, Antioxidant, and Antifungal Activities of β-Ionone Thiazolylhydrazone Derivatives and Their Application in Anti-Browning of Freshly Cut Potato
Authors: Huang Cong , Zhong Yuan , Zeng Rong , Wang Jie , Fang Qingwen , Xiao Shuzhen , Zhang Ji , Wang Zongde , Chen Shangxing , Peng Dayong
Published: September 2023

In order to develop a new type of antioxidants with high efficiency, a series of β-ionone thiazolylhydrazone derivatives were designed and synthesized from β-ionone, and their structures were characterized by 1H-NMR, 13C-NMR, FT-IR, and HR-MS. The antioxidant test in vitro indicated that most of the target compounds had high biological activity. Among them, compound 1k exhibited very strong DPPH (1,1-diphenyl-2-picrylhydrazyl radical)-scavenging activity with a half-maximal effective concentration (IC50) of 86.525 μM. Furthermore, in the ABTS (2,2-azinobis (3-ethylbenzothiazoline-6-sulfonate) diammonium salt)-scavenging experiment, compound 1m exhibited excellent activity with an IC50 of 65.408 μM. Their biological activities were significantly better than those of the positive control Trolox. These two compounds, which have good free-radical-scavenging activity in vitro, were used as representative compounds in the anti-browning experiment of fresh-cut potatoes. The results showed that 1k and 1m had the same anti-browning ability as kojic acid, and they were effective browning inhibitors. In addition, it is well known that microbial infection is one of the reasons for food oxidation. Therefore, we investigated the antifungal activity of 25 target compounds against eight plant fungi at a concentration of 125 mg/L. The results indicated that these compounds all have some antifungal activity and may become new potential fungicides. Notably, compound 1u showed the best inhibitory effect against Poria vaporaria, with an inhibition rate as high as 77.71%; it is expected to become the dominant structure for the development of new antifungal agents.
Strategies and Applications of Graphene and Its Derivatives-Based Electrochemical Sensors in Cancer Diagnosis
Authors: Fu Li , Zheng Yuhong , Li Xingxing , Liu Xiaozhu , Lin Cheng-Te , Karimi-Maleh Hassan
Published: September 2023

Graphene is an emerging nanomaterial increasingly being used in electrochemical biosensing applications owing to its high surface area, excellent conductivity, ease of functionalization, and superior electrocatalytic properties compared to other carbon-based electrodes and nanomaterials, enabling faster electron transfer kinetics and higher sensitivity. Graphene electrochemical biosensors may have the potential to enable the rapid, sensitive, and low-cost detection of cancer biomarkers. This paper reviews early-stage research and proof-of-concept studies on the development of graphene electrochemical biosensors for potential future cancer diagnostic applications. Various graphene synthesis methods are outlined along with common functionalization approaches using polymers, biomolecules, nanomaterials, and synthetic chemistry to facilitate the immobilization of recognition elements and improve performance. Major sensor configurations including graphene field-effect transistors, graphene modified electrodes and nanocomposites, and 3D graphene networks are highlighted along with their principles of operation, advantages, and biosensing capabilities. Strategies for the immobilization of biorecognition elements like antibodies, aptamers, peptides, and DNA/RNA probes onto graphene platforms to impart target specificity are summarized. The use of nanomaterial labels, hybrid nanocomposites with graphene, and chemical modification for signal enhancement are also discussed. Examples are provided to illustrate applications for the sensitive electrochemical detection of a broad range of cancer biomarkers including proteins, circulating tumor cells, DNA mutations, non-coding RNAs like miRNA, metabolites, and glycoproteins. Current challenges and future opportunities are elucidated to guide ongoing efforts towards transitioning graphene biosensors from promising research lab tools into mainstream clinical practice. Continued research addressing issues with reproducibility, stability, selectivity, integration, clinical validation, and regulatory approval could enable wider adoption. Overall, graphene electrochemical biosensors present powerful and versatile platforms for cancer diagnosis at the point of care.
Metformin-Loaded Chitosan Hydrogels Suppress Bladder Tumor Growth in an Orthotopic Mouse Model via Intravesical Administration
Authors: Zhang Xingjian , Hu Xin , Xie Yijun , Xie Lejing , Chen Xiangyi , Peng Mei , Li Duo , Deng Jun , Xiao Di , Yang Xiaoping
Published: September 2023

Our previous study found that the intravesical perfusion of metformin has excellent inhibitory effects against bladder cancer (BC). However, this administration route allows the drug to be diluted and excreted in urine. Therefore, increasing the adhesion of metformin to the bladder mucosal layer may prolong the retention time and increase the pharmacological activity. It is well known that chitosan (Cs) has a strong adhesion to the bladder mucosal layer. Thus, this study established a novel formulation of metformin to enhance its antitumor activity by extending its retention time. In this research, we prepared Cs freeze-dried powder and investigated the effect of metformin-loaded chitosan hydrogels (MLCH) in vitro and in vivo. The results showed that MLCH had a strong inhibitory effect against proliferation and colony formation in vitro. The reduction in BC weight and the expression of tumor biomarkers in orthotopic mice showed the robust antitumor activity of MLCH via intravesical administration in vivo. The non-toxic profile of MLCH was observed as well, using histological examinations. Mechanistically, MLCH showed stronger functional activation of the AMPKα/mTOR signaling pathway compared with metformin alone. These findings aim to make this novel formulation an efficient candidate for managing BC via intravesical administration.
Ethanolic Extract of Polygonum minus Protects Differentiated Human Neuroblastoma Cells (SH-SY5Y) against H2O2-Induced Oxidative Stress
Authors: Sayuti Nor Hafiza , Zulkefli Nabilah , Tan Jen Kit , Saad Norazalina , Baharum Syarul Nataqain , Hamezah Hamizah Shahirah , Bunawan Hamidun , Ahmed Qamar Uddin , Parveen Humaira , Mukhtar Sayeed , Alsharif Meshari A. , Sarian Murni Nazira
Published: September 2023

Neuronal models are an important tool in neuroscientific research. Hydrogen peroxide (H2O2), a major risk factor of neuronal oxidative stress, initiates a cascade of neuronal cell death. Polygonum minus Huds, known as ‘kesum’, is widely used in traditional medicine. P. minus has been reported to exhibit a few medicinal and pharmacological properties. The current study aimed to investigate the neuroprotective effects of P. minus ethanolic extract (PMEE) on H2O2-induced neurotoxicity in SH-SY5Y cells. LC–MS/MS revealed the presence of 28 metabolites in PMEE. Our study showed that the PMEE provided neuroprotection against H2O2-induced oxidative stress by activating the Nrf2/ARE, NF-κB/IκB and MAPK signaling pathways in PMEE pre-treated differentiated SH-SY5Y cells. Meanwhile, the acetylcholine (ACH) level was increased in the oxidative stress-induced treatment group after 4 h of exposure with H2O2. Molecular docking results with acetylcholinesterase (AChE) depicted that quercitrin showed the highest docking score at −9.5 kcal/mol followed by aloe-emodin, afzelin, and citreorosein at −9.4, −9.3 and −9.0 kcal/mol, respectively, compared to the other PMEE’s identified compounds, which show lower docking scores. The results indicate that PMEE has neuroprotective effects on SH-SY5Y neuroblastoma cells in vitro. In conclusion, PMEE may aid in reducing oxidative stress as a preventative therapy for neurodegenerative diseases.
Quartz-Enhanced Photoacoustic Spectroscopy Assisted by Partial Least-Squares Regression for Multi-Gas Measurements
Authors: Rasmussen Andreas N. , Thomsen Benjamin L. , Christensen Jesper B. , Petersen Jan C. , Lassen Mikael
Published: September 2023

We report on the use of quartz-enhanced photoacoustic spectroscopy (QEPAS) for multi-gas detection. Photoacoustic (PA) spectra of mixtures of water (H2O), ammonia (NH3), and methane (CH4) were measured in the mid-infrared (MIR) wavelength range using a mid-infrared (MIR) optical parametric oscillator (OPO) light source. Highly overlapping absorption spectra are a common challenge for gas spectroscopy. To mitigate this, we used a partial least-squares regression (PLS) method to estimate the mixing ratio and concentrations of the individual gasses. The concentration range explored in the analysis varies from a few parts per million (ppm) to thousands of ppm. Spectra obtained from HITRAN and experimental single-molecule reference spectra of each of the molecular species were acquired and used as training data sets. These spectra were used to generate simulated spectra of the gas mixtures (linear combinations of the reference spectra). Here, in this proof-of-concept experiment, we demonstrate that after an absolute calibration of the QEPAS cell, the PLS analyses could be used to determine concentrations of single molecular species with a relative accuracy within a few % for mixtures of H2O, NH3, and CH4 and with an absolute sensitivity of approximately 300 (±50) ppm/V, 50 (±5) ppm/V, and 5 (±2) ppm/V for water, ammonia, and methane, respectively. This demonstrates that QEPAS assisted by PLS is a powerful approach to estimate concentrations of individual gas components with considerable spectral overlap, which is a typical scenario for real-life adoptions and applications.
A Stacked Long Short-Term Memory Approach for Predictive Blood Glucose Monitoring in Women with Gestational Diabetes Mellitus
Authors: Lu Huiqi Y. , Lu Ping , Hirst Jane E. , Mackillop Lucy , Clifton David A.
Published: September 2023

Gestational diabetes mellitus (GDM) is a subtype of diabetes that develops during pregnancy. Managing blood glucose (BG) within the healthy physiological range can reduce clinical complications for women with gestational diabetes. The objectives of this study are to (1) develop benchmark glucose prediction models with long short-term memory (LSTM) recurrent neural network models using time-series data collected from the GDm-Health platform, (2) compare the prediction accuracy with published results, and (3) suggest an optimized clinical review schedule with the potential to reduce the overall number of blood tests for mothers with stable and within-range glucose measurements. A total of 190,396 BG readings from 1110 patients were used for model development, validation and testing under three different prediction schemes: 7 days of BG readings to predict the next 7 or 14 days and 14 days to predict 14 days. Our results show that the optimized BG schedule based on a 7-day observational window to predict the BG of the next 14 days achieved the accuracies of the root mean square error (RMSE) = 0.958 ± 0.007, 0.876 ± 0.003, 0.898 ± 0.003, 0.622 ± 0.003, 0.814 ± 0.009 and 0.845 ± 0.005 for the after-breakfast, after-lunch, after-dinner, before-breakfast, before-lunch and before-dinner predictions, respectively. This is the first machine learning study that suggested an optimized blood glucose monitoring frequency, which is 7 days to monitor the next 14 days based on the accuracy of blood glucose prediction. Moreover, the accuracy of our proposed model based on the fingerstick blood glucose test is on par with the prediction accuracies compared with the benchmark performance of one-hour prediction models using continuous glucose monitoring (CGM) readings. In conclusion, the stacked LSTM model is a promising approach for capturing the patterns in time-series data, resulting in accurate predictions of BG levels. Using a deep learning model with routine fingerstick glucose collection is a promising, predictable and low-cost solution for BG monitoring for women with gestational diabetes.
Blockchain-Based Smart Farm Security Framework for the Internet of Things
Authors: Aliyu Ahmed Abubakar , Liu Jinshuo
Published: September 2023

Smart farming, as a branch of the Internet of Things (IoT), combines the recognition of agricultural economic competencies and the progress of data and information collected from connected devices with statistical analysis to characterize the essentials of the assimilated information, allowing farmers to make intelligent conclusions that will maximize the harvest benefit. However, the integration of advanced technologies requires the adoption of high-tech security approaches. In this paper, we present a framework that promises to enhance the security and privacy of smart farms by leveraging the decentralized nature of blockchain technology. The framework stores and manages data acquired from IoT devices installed in smart farms using a distributed ledger architecture, which provides secure and tamper-proof data storage and ensures the integrity and validity of the data. The study uses the AWS cloud, ESP32, the smart farm security monitoring framework, and the Ethereum Rinkeby smart contract mechanism, which enables the automated execution of pre-defined rules and regulations. As a result of a proof-of-concept implementation, the system can detect and respond to security threats in real time, and the results illustrate its usefulness in improving the security of smart farms. The number of accepted blockchain transactions on smart farming requests fell from 189,000 to 109,450 after carrying out the first three tests while the next three testing phases showed a rise in the number of blockchain transactions accepted on smart farming requests from 176,000 to 290,786. We further observed that the lesser the time taken to induce the device alarm, the higher the number of blockchain transactions accepted on smart farming requests, which demonstrates the efficacy of blockchain-based poisoning attack mitigation in smart farming.
Effect of Protective Layer on the Performance of Monocrystalline Silicon Cell for Indoor Light Harvesting
Authors: Hammam Tarek M. , Alhalaili Badriyah , Abd El-sadek M. S. , Abuelwafa Amr Attia
Published: September 2023

The development of renewable energy sources has grown increasingly as the world shifts toward lowering carbon emissions and supporting sustainability. Solar energy is one of the most promising renewable energy sources, and its harvesting potential has gone beyond typical solar panels to small, portable devices. Also, the trend toward smart buildings is becoming more prevalent at the same time as sensors and small devices are becoming more integrated, and the demand for dependable, sustainable energy sources will increase. Our work aims to tackle the issue of identifying the most suitable protective layer for small optical devices that can efficiently utilize indoor light sources. To conduct our research, we designed and tested a model that allowed us to compare the performance of many small panels made of monocrystalline cells laminated with three different materials: epoxy resin, an ethylene–tetrafluoroethylene copolymer (ETFE), and polyethylene terephthalate (PET), under varying light intensities from LED and CFL sources. The methods employed encompass contact angle measurements of the protective layers, providing insights into their wettability and hydrophobicity, which indicates protective layer performance against humidity. Reflection spectroscopy was used to evaluate the panels’ reflectance properties across different wavelengths, which affect the light amount arrived at the solar cell. Furthermore, we characterized the PV panels’ electrical behavior by measuring short-circuit current (ISC), open-circuit voltage (VOC), maximum power output (Pmax), fill factor (FF), and load resistance (R). Our findings offer valuable insights into each PV panel’s performance and the protective layer material’s effect. Panels with ETFE layers exhibited remarkable hydrophobicity with a mean contact angle of 77.7°, indicating resistance against humidity-related effects. Also, panels with ETFE layers consistently outperformed others as they had the highest open circuit voltage (VOC) ranging between 1.63–4.08 V, fill factor (FF) between 35.9–67.3%, and lowest load resistance (R) ranging between 11,268–772 KΩ.cm−2 under diverse light intensities from various light sources, as determined by our results. This makes ETFE panels a promising option for indoor energy harvesting, especially for powering sensors with low power requirements. This information could influence future research in developing energy harvesting solutions, thereby making a valuable contribution to the progress of sustainable energy technology.
Accurate and Low-Power Ultrasound–Radiofrequency (RF) Indoor Ranging Using MEMS Loudspeaker Arrays
Authors: Buyle Chesney , De Strycker Lieven , Van der Perre Liesbet
Published: September 2023

Accurately positioning energy-constrained devices in indoor environments is of great interest to many professional, care, and personal applications. Hybrid RF–acoustic ranging systems have shown to be a viable technology in this regard, enabling accurate distance measurements at ultra-low energy costs. However, they often suffer from self-interference due to multipaths in indoor environments. We replace the typical single loudspeaker beacons used in these systems with a phased loudspeaker array to promote the signal-to-interference-plus-noise ratio towards the tracked device. Specifically, we optimize the design of a low-cost uniform planar array (UPA) through simulation to achieve the best ranging performance using ultrasonic chirps. Furthermore, we compare the ranging performance of this optimized UPA configuration to a traditional, single-loudspeaker system. Simulations show that vertical phased-array configurations guarantee the lowest ranging errors in typical shoe-box environments, having a limited height with respect to their length and width. In these cases, a P50 ranging error of around 3 cm and P95 ranging error below 30 cm were achieved. Compared to a single-speaker system, a 10 × 2 vertical phased array was able to lower the P80 and P95 up to an order of magnitude.
Design of A High-Precision Component-Type Vertical Pendulum Tiltmeter Based on FPGA
Authors: Xu Xin , Chen Zheng , Li Hong , Ma Shigui , Wu Liheng , Wang Wenbo , Dong Yunkai , Zhan Weiwei
Published: September 2023

This paper presents a high-precision component-type vertical pendulum tiltmeter based on an FPGA (Field Programmable Gate Array) that improves the utility and reliability of geophysical field tilt observation instruments. The system is designed for rapid deployment and offers flexible and efficient adaptability. It comprises a pendulum body, a triangular platform, a locking motor and sealing cover, a ratiometric measurement bridge, a high-speed ADC, and an FPGA embedded system. The pendulum body is a plumb-bob-type single-suspension wire vertical pendulum capable of measuring ground tilt in two orthogonal directions simultaneously. It is installed on a triangular platform, sealed as a whole, and equipped with a locking motor to withstand a free-fall impact of 2 m. The system utilizes a differential capacitance ratio bridge in the measurement circuit, replacing analog circuits with high-speed AD sampling and FPGA digital signal processing technology. This approach reduces hardware expenses and interferences from active devices. The system also features online compilation functionality for flexible measurement parameter settings, high reliability, ease of use, and rapid deployment without the need for professional technical personnel. The proposed tiltmeter holds significant importance for further research in geophysics.
The Use of the Smart Technology for Creating an Inclusive Urban Public Space
Authors: Itair Mohammed , Shahrour Isam , Hijazi Ihab
Published: September 2023

This paper strives to enhance the inclusivity of urban public spaces, which play a crucial role in providing essential services for all citizens, including community building, physical and mental well-being, social interaction, civic engagement, citizen participation, and economic vitality. Despite the importance of these spaces, as recognized by the UN’s 2030 sustainability goals, the 2023 UN sustainable development report and scholars have drawn attention to their low availability, particularly for low-income individuals, women, children, and people with disabilities. To improve the inclusivity of public spaces, this paper offers the following contributions. (i) The establishment of a comprehensive framework for assessing public space inclusivity. This framework incorporates eight indicators: spatial distribution, typology, facilities and services, green and humid areas, governance and management, safety, user categories, and user satisfaction. (ii) The utilization of the framework to assess the inclusivity of public spaces in Nablus, a major Palestinian city. This assessment confirms the observations made by the UN and scholars regarding the low inclusivity of public spaces; in particular, a lack of public space, poor spatial distribution, and user dissatisfaction with safety conditions and services. (iii) The introduction of the concept of smart public space, which involves citizens in the governance of this space and leverages smart technology for monitoring, providing real-time information and services to citizens, improving facility efficiency, and creating an eco-friendly environment that preserves resources and biodiversity. By addressing these aspects, this paper enhances inclusivity. It promotes the development of an urban public space that caters to the diverse needs of the community, fostering a sense of belonging and well-being for all.
Short-Term Forecasting of Electric Vehicle Load Using Time Series, Machine Learning, and Deep Learning Techniques
Authors: Vishnu Gayathry , Kaliyaperumal Deepa , Pati Peeta Basa , Karthick Alagar , Subbanna Nagesh , Ghosh Aritra
Published: September 2023

Electric vehicles (EVs) are inducing revolutionary developments to the transportation and power sectors. Their innumerable benefits are forcing nations to adopt this sustainable mode of transport. Governments are framing and implementing various green energy policies. Nonetheless, there exist several critical challenges and concerns to be resolved in order to reap the complete benefits of E-mobility. The impacts of unplanned EV charging are a major concern. Accurate EV load forecasting followed by an efficient charge scheduling system could, to a large extent, solve this problem. This work focuses on short-term EV demand forecasting using three learning frameworks, which were applied to real-time adaptive charging network (ACN) data, and performance was analyzed. Auto-regressive (AR) forecasting, support vector regression (SVR), and long short-term memory (LSTM) frameworks demonstrated good performance in EV charging demand forecasting. Among these, LSTM showed the best performance with a mean absolute error (MAE) of 4 kW and a root-mean-squared error (RMSE) of 5.9 kW.
Mecanismos de acción y tratamiento del accidente cerebrovascular isquémico por COVID-19
Authors: Ayala Patiño Manuel Anthony , Yánez Castro Jorge Luis
Published: September 2023

Diversos mecanismos inflamatorios y protrombóticos pueden contribuir al aumento del riesgo de eventos cardiovasculares y accidentes cerebrovasculares en pacientes con COVID-19, afectando el enfoque del tratamiento y manejo de la enfermedad. La evidencia relacionada con los mecanismos fisiopatológicos del COVID-19 y su asociación con los accidentes cerebrovasculares son relevantes para guiar el tratamiento y el manejo de los pacientes, considerados como desafíos terapéuticos que surgen durante períodos de contagio masivo. Objetivo. Describir el mecanismo de acción y tratamiento del evento cerebro vascular isquémico por COVID-19. Metodología. Se realizó una revisión exhaustiva de la literatura mediante una revisión sistemática, en conformidad con las directrices establecidas por la declaración PRISMA. Se recopiló información de múltiples bases de datos científicas, utilizando términos y palabras clave ("Mecanismos de acción" OR "Mecanismos fisiopatológicos") AND ("Accidente cerebrovascular isquémico" OR "ACV isquémico") relacionados con los mecanismos de acción y tratamiento del accidente cerebrovascular isquémico asociado al COVID-19. Resultados. En total se obtuvo 41 entre PubMed y Science direct, previo a criterios 12 fueron seleccionados. Conclusión. Se determinaron los mecanismos de acción desencadenados por el COVID-19 para la formación de trombos y su relación con los accidentes cerebrovasculares. Además, se comprendió cómo el tratamiento de los accidentes cerebrovasculares afectaba a los pacientes que también padecían COVID-19. Se encontró que la tormenta de citocinas era un mecanismo influyente en la fisiopatología del COVID-19. En cuanto al tratamiento, la identificación de la enfermedad infecciosa causada por el virus SARS-CoV-2 resultó crucial en la gestión de los pacientes con accidente cerebrovascular
"GOOD DESIGN" IN THE METAVERSE: TOWARD A PROBLEM STATEMENT
Authors: Rod'kin P.
Published: September 2023

The article actualizes design modernist principles of "good design" in the new operational, functional and semantic space of the meta-universe. The meta-universe is problematized and critically analyzed in the broad context of technological substitution, marketization, interoperability, and other socially significant phenomena of the real and digital environment. We have conducted a comparative analysis of the principles of good design by Dieter Rams and Adobe corp.; considered the current debate in science, experts and the public on the prospects of the meta-universe development, opportunities and risks associated with the design of competing with architecture; outlined urgent tasks to address problems and challenges in the selected problem area. Good design is considered as a key theoretical concept of contemporary (trendy) design, the required intellectual and humanitarian basis for conceptual management and the formation of aesthetic and ethical standards of the new socio-economic and cultural reality that the meta-universe opens
L’incompréhension linguistique et le rôle des interprètes dans les conciles du milieu du Ve siècle
Authors: Huntzinger Hervé
Published: September 2023

By their very nature, ancient sources do not provide an easy tool to study the socio-linguistic aspects of late antique multilingualism. Though, the detailed minutes of the council of Chalcedon and the preceding synods give us access to practical acts of linguistic misunderstanding between the dominant Greek language used by most of the bishops and the minority use of Latin or Syriac languages by non-Greek speakers. This paper shows that rather than leading to fundamental dissent, as shown by the resolution of the Ibas case, it made the roman delegation dependent of the imperial officials.
Nicomaque Flavien syriacophone dans la Vie d’Aurélien. Des réminiscences d’Eusèbe de Césarée dans l’Histoire Auguste ?
Authors: Arbo Agnès
Published: September 2023

Intertextuality in the Historia Augusta is a very complex topic. In this paper, I analyze a sentence from the Vita Aureliani (27, 6), which follows the quotation of two letters forged by the biographer. This sentence gives fanciful details about the original language of the two letters, and it even explains that a certain Nicomachus translated the second one from Aramaic into Greek. The author may in fact be crossing two literary references: the pagan Nicomachus Flavianus Senior and the Christian Eusebius of Caesarea who, in his historical writings, often mentioned the original language of the documents he translated to support his claims of authenticity.
Regards gaulois sur la Britannia sous la Tétrarchie. La panégyristique de l’intégration
Authors: Mastrorosa Ida Gilda
Published: September 2023

En analysant certains passages des Panégyriques latins, cette contribution se focalise sur la représentation que se faisaient les intellectuels gaulois de la Britannia à l’âge de la Tétrarchie ainsi que sur leur conception politique des confins septentrionaux de l’oecoumène assujettie aux Romains. Au-delà d’un intérêt pour les caractéristiques climatiques, environnementales et anthropologiques de l’île, certaines considérations dans les Panégyriques IV [8], V [9], VII [6], suggèrent qu’après la soustraction de l’île aux ennemis Carausius et Allectus par Constance (296), les rhéteurs gaulois visaient à promouvoir le rôle-clef de la Britannia dans le processus de stabilisation de l’unité de l’empire.
Introduction
Authors: Rey Sarah
Published: September 2023

Alors que les supplications grecques ont été analysées de plusieurs manières, dans les textes ou les images, les supplications romaines restent imparfaitement connues. C’est lié à leur polyvalence et, dans une certaine mesure, à leur banalité. Souvent déterminées par le statut social des suppliants, elles prennent place dans divers contextes (cultuel, politique, judiciaire, militaire), qu’il convient d’observer un à un, ne serait-ce que pour tenter de voir ce qui relève de la simple prière et ce qui appartient à la supplication proprement dite, dans ses formes parfois dramatiques. Ce dossier a l’ambition d’étudier le devenir des suppliques sous le Haut-Empire.
Déclin et stabilité des régimes dans la Politique d’Aristote
Authors: Lévy Edmond
Published: September 2023

Aristotle criticizes the situation of Greece, which results in his eyes from a very bad evolution, but unlike Plato he does not believe in a continual decay, and he prefers to distinguish between the varieties of each regime and to explain how to preserve them through moderation.
Jura conloqui. Mechanisms in Official Interviews with Punic Leaders in the Time of the Roman Republican Expansion
Authors: Rosselló Calafell Gabriel
Published: September 2023

Direct, official contact between leaders took place in various politico-military circumstances during the period of the Roman Republican expansion. One of these situations is the conloquia, or face-to-face interviews between military chiefs. This diplomatic practice, previously studied by scholars such as García Riaza, has a series of common procedures, as we can deduce from reading the classic texts. These mechanisms seem to have been observed and shared by the Carthaginian commanders and those of other communities and states of the Mediterranean West, which would place us in front of a common framework of diplomatic practice.
La société civile face au nucléaire militaire
Authors: Bordé Jacques
Published: September 2023

Nous examinons l’évolution de la perception de l’arme nucléaire par la population civile française et internationale. Celle-ci évolue lentement à partir d’une adhésion aveugle à la dissuasion nucléaire par des citoyens endoctrinés vers une réflexion raisonnée et informée sur le rapport bénéfice/ risque qu’elle procure. On décrit les organisations qui ont lancé cette réflexion et obtenu des résultats politiques significatifs (dont le Traité d’interdiction des armes nucléaires) ainsi que des sondages qui montrent l’évolution en cours chez les citoyens. Enfin on souligne les conditions à réunir pour permettre à chacun d’exprimer un avis éclairé pour ou contre la possession d’armes nucléaires.
La Palestine : l’obscurité du présent et l’ambiguïté de l’avenir
Authors: Khalil Saïd
Published: September 2023

Si la colonisation, l’occupation et l’apartheid définissent les conditions d’existence de la Palestine, cette dernière est aussi soumise à des enjeux sociaux et politiques internes peu connus du grand public. Cet article envisage d’en explorer un certain nombre en se focalisant sur les enjeux politiques du délitement de la cause palestinienne ainsi que sur l’avenir à court terme et à plus long terme ; le pessimisme étant malheureusement le trait d’union de ces périodes.
L’Asie centrale ou la reconfiguration d’un monde post-poutinien
Authors: Lincot Emmanuel
Published: September 2023

L’Asie centrale, nouveau centre du monde ? La Chine y a redécouvert, à la faveur des indépendances, une profondeur stratégique. Elle lui donne à la fois accès à l’Union européenne et au Moyen-Orient. Empêtrée dans la guerre menée contre l’Ukraine, la marginalisation de Moscou profite au renforcement des positions et des partenariats établis par Pékin dans cette partie du monde. La Chine renoue ainsi à travers le narratif des Nouvelles Routes de la Soie avec une histoire multiséculaire et des enjeux que lui disputent les grandes puissances régionales que sont la Turquie, l’Iran, l’Inde voire les pays du Golfe. Un très «Grand Jeu» en somme qui met aux prises des cultures politiques dont les référents s’inspirent souvent de matrices et de mythologies communes. Soviétisme pour les uns, panturquisme pour les autres, sans oublier le rejet viscéral de ces hommes de l’ombre, djihadistes ouïghours notamment, qui rejettent en bloc l’autorité de la Chine. Perçue comme un État colonial par les opinions, le rêve de pacification des régions du grand Ouest, du Xinjiang et de l’étranger proche, coïncide pour la Chine et son dirigeant Xi Jinping avec un projet normatif de grande ampleur, synonyme d’opportunités marchandes et de glacis stratégique. Gageure ou réalité probable ? Cet article tente d’apporter des réponses à cette question.
La culture de la paix et de la non-violence, une alternative politique ?
Authors: Godinot Etienne , Porteilla Raphaël
Published: September 2023

Si pour certains la non-violence n’est pas une perspective, voire serait contraire aux valeurs de la République, pour d’autres elle est un mode opératoire efficace contre les régimes autoritaires, et même une philosophie de vie. Cet article se propose d’ouvrir sur quelques éclairages relatifs au concept de violence, pour tenter ensuite de clarifier les principaux concepts adjacents et, enfin, finir sur les potentialités politiques de la culture de la paix et de la non-violence.
Competency Needs Assessment of 4-H Youth Development Professionals
Authors: Benge Matt
Published: September 2023

Understanding and identifying the professional development needs of 4-H youth development professionals should be the first step in developing the Extension workforce. However, 4-H professionals find it challenging to use the Professional, Research, Knowledge and Competencies (PRKC), which consists of 348 unique competency items, to guide professional development trainings. The purpose of the study was to determine the professional development needs of National Association of Extension 4-H Youth Development Professionals (NAE4-HYDP) members. A Borich model was used to create a top 10 prioritized list of each PRKC domain to guide professional development of NAE4-HYDP members.
After the Disaster Guidebook: Designing a Post-Disaster Communication Intervention for Rural Landowners
Authors: Bice Channing , Carter Susan
Published: September 2023

Extension is well-positioned to facilitate communication strategies that foster community resilience and disaster recovery, particularly for rural residents. This paper proposes a new approach to post-disaster communication that strengthens rural community capacities in locally and culturally relevant ways. The findings revealed specific post-disaster information needs, preferences for local resources, and communication that encourages resilience through a document analysis and interviews with informants recovering from the 2020 Colorado wildfires. The practical recommendations discussed serve as a starting point for Extension professionals in other areas to consider ways to engage with their communities before, during, and after a disaster.
Direct Marketing via US Postal Service’s Every Door Direct Mail Program
Authors: Ehmke Cole
Published: September 2023

In this paper I describe the US Postal Service’s Every Door Direct Mail program which delivers postcards inexpensively to residents within a ZIP code. Extension educators interested in making the most of their advertising dollars can use the EDDM program advantageously. Best practices for advertising campaigns employing this direct mail option are provided.
Estudo comparativo entre a realidade de Belém-PA e cidades de Brasília-DF e Santa Maria-RS, quanto a durabilidade de fachadas, sob á ação do calor, choque térmico e chuva dirigida
Authors: Netto Alemar Dias Rodrigues , De Alencar Antonio Fabricio Rodrigues , Quirxtner Junior Franz Gernot , De Lima Maylon Almeida , Santos Miqueias da Conceição , Neri Tonio Marcio , Ferreira Taiza Naiana da Silva
Published: September 2023

Este trabalho trata, principalmente, de uma revisão acerca da produção acadêmica científica sobre a análise quanto ao desempenho das fachadas, expostas às ações climáticas, situadas em 03 diferentes zonas bioclimáticas brasileiras. Tal estudo comparativo, consiste em verificar os níveis de exposição e os agentes de degradação correspondente a cada uma dessas regiões, bem como a análise dos materiais que compõem estas fachadas. O trabalho foi realizado com base em pesquisa bibliográfica, onde obteve um resultado de 32 artigos relacionados, no entanto, apenas 07 artigos apresentaram similitude com o tema. Como resultado da pesquisa, foi identificado dentre as cidades de Belém-PA, Brasília-DF e Santa Maria-RS, a zona mais crítica (Z2) e a mais amena (Z8), quanto ao grau de exposição e surgimento de agentes de degradação, na qual atuam como marcadores ao mapeamento de possíveis patologias prediais.
THE USE OF COMPUTER-AIDED DESIGN SYSTEMS IN THE WORK OF AN ARTIST-DESIGNER OF JEWELRY
Authors: Zaeva Nadezda A. , Bezdenezhnykh Alla G. , Kargina Svetlana I.
Published: September 2023

The article deals with the issue of a set of technical requirements for the design project of a jewelry. Unlike graphic design, which does not require the implementation of the project in the material, jewelry design can be considered realized only if the product is manufactured or can be successfully implemented without loss of artistic and figurative characteristics. An emotionally colored creative process is inextricably linked with an engineering and intellectual approach to problem solving, including the preparation of design documentation. The use of a three-dimensional design system in the creation of jewelry and art products not only accelerates the process of design implementation of the idea, but also helps to transfer these ideas into industrial production as accurately and technically as possible.
Adoption and development of OERs and practices for self-directed learning: A South African perspective
Authors: Van Der Berg Geesje , Du Toit-Brits Charlene
Published: September 2023

The use of open educational resources (OERs) within the broader context of open educational practices (OEPs) has many advantages, including the potential to result in self-directed learning, as students take responsibility for their learning. However, despite their vast potential, the promise of OERs has not yet translated into concrete and tangible OER adoption and development in the Global South, and specifically in South Africa. It also seems that the flow of OERs is mostly in one direction, namely from developed to developing country contexts. The purpose of this article is to determine what the literature reveals regarding OER adoption and development in South Africa. Within an interpretivist paradigm and a qualitative approach, we used an integrative literature review to collect data. Two large databases were consulted, and after applying the chosen inclusion and exclusion criteria, six relevant texts were found and discussed. The findings reveal that limited research is available. Furthermore, it became clear that OER planning, adoption and development is a process, and that collaboration and institutional support and leadership play important roles in the state of OER adoption, development and projects. The literature also revealed that despite the benefits of using OERs, there are stumbling blocks to adopting and using OERs in South Africa. Based on the findings, it is suggested that OERs for self-directed learning should advance and develop teaching and learning, by supporting flexibility and openness of learning resources. Lastly, to grow the use of OERs, with specific reference to South Africa, ongoing research on the state of OER adoption and development is needed.
PROBLEM PENGGUNAAN WEBSITE OLEH NOTARIS SELAKU PEJABAT PUBLIK
Authors: Salsabila  , Wijaya Endra
Published: September 2023

Kajian ini membahas mengenai notaris selaku pejabat publik yang dalam melaksanakan kewenangannya dibatasi oleh beberapa larangan. Larangan-larangan tersebut diatur dalam undang-undang maupun Kode Etik Notaris, dan salah satu di antara larangan itu ialah larangan untuk tidak melakukan aktivitas mempromosikan diri menggunakan media elektronik, termasuk website. Kajian ini menggunakan metode penelitian hukum nondoktrinal. Kajian ini menyimpulkan bahwa beberapa notaris memang masih menggunakan media elektronik berupa website untuk mempromosikan dirinya selaku pejabat notaris. Dari perspektif undang-undang maupun Kode Etik Notaris, tindakan tersebut cenderung bertentangan dengan beberapa kewajiban serta larangan bagi notaris selaku pejabat publik. Terhadap bentuk pelanggaran seperti itu, Dewan Kehormatan atau Majelis Pengawas dapat memeriksa dan menjatuhkan sanksi kepada notaris yang bersangkutan.