bluuebunny/crossref_metadata_2025 huggingface dataset:
Diagnostic accuracy of baseline troponin and troponin change for the diagnosis of myocardial infarction complicated with heart failure
Authors: Serenelli Matteo , Dal Passo Beatrice , Biscaglia Simone , Tolomeo Paolo , Di Ienno Luca , Cantone Anna , Sanguettoli Federico , Campana Roberta , Marchini Federico , Arzenton Matteo , Maio Daniele , Santori Valentino , Campo Gianluca
Published: March 2024

Background

The diagnosis of myocardial infarction (MI) in the presence of heart failure (HF) presents a clinical problem. While diagnostic algorithms using high-sensitivity cardiac troponin have been established for suspected MI, their accuracy in patients with HF remains uncertain. This study aims to assess the diagnostic accuracy of high-sensitivity troponin I (TnI) levels in identifying acute MI among patients with HF, focusing on baseline, absolute and relative TnI changes.

Methods

Data from 562 individuals admitted to the emergency department with suspected MI were retrospectively analysed. Two-point TnI and baseline brain natriuretic peptide (BNP) test results were available. HF status was determined based on clinical, laboratory and instrumental criteria.

Results

Among the 562 patients, 299 (53.2%) were confirmed having MI. Baseline TnI demonstrated predictive capability for MI in the overall population (area under the curve (AUC) 0.63), while TnI relative change exhibited superior performance (AUC 0.83). Baseline TnI accuracy varied significantly by group, notably decreasing in the third group (severe HF) (AUC 0.54) compared with the first and second groups (AUC 0.67 and AUC 0.71, respectively). TnI relative change demonstrated consistent accuracy across all groups, with AUCs of 0.79, 0.79 and 0.89 for the first, second and third groups, respectively, even after adjustment for age, sex and glomerular filtration rate.

Discussion

Troponin relative change is a reliable predictor of MI, even in patients with acute HF. Baseline TnI accuracy is influenced by HF severity. It is essential to consider HF status and BNP levels when employing high-sensitivity cardiac troponin testing to rule out suspected MIs.
Long-term efficacy of a 2-year MRI treat-to-target strategy on disease activity and radiographic progression in patients with rheumatoid arthritis in clinical remission: 5-year follow-up of the IMAGINE-RA randomised trial
Authors: Møller-Bisgaard Signe , Hørslev-Petersen Kim , Ørnbjerg Lykke Midtbøll , Ejbjerg Bo , Hetland Merete Lund , Møller Jakob Møllenbach , Nielsen Sabrina Mai , Glinatsi Daniel , Boesen Mikael , Stengaard-Pedersen Kristian , Madsen Ole Rintek , Jensen Bente , Villadsen Jan Alexander , Hauge Ellen Margrethe , Hendricks Oliver , Lindegaard Hanne , Krogh Niels Steen , Jurik Anne Grethe , Thomsen Henrik , Christensen Robin , Østergaard Mikkel
Published: March 2024

Objective

To investigate whether a 2-year MRI treat-to-target strategy targeting the absence of osteitis combined with clinical remission, compared with a conventional treat-to-target strategy targeting clinical remission only (IMAGINE-rheumatoid arthritis (RA) trial) improves clinical and radiographic outcomes over 5 years in patients with RA in clinical remission.

Methods

IMAGINE-more was an observational extension study of the original 2-year IMAGINE-RA randomised trial (NCT01656278). Clinical examinations and radiographs (hands and feet) were obtained yearly. Prespecified coprimary outcomes at year 5 were Disease Activity Score in 28 joints C reactive protein (DAS28-CRP) remission rate (DAS28-CRP<2.6) and no radiographic progression (van der Heijde-modified Sharp score (vdHSS) ≤0) from baseline. Secondary outcomes included 5-year changes in radiographic, MRI and clinical measures of disease activity and physical function.

Results

In total 131 patients, 86 women (67%), mean age 61.2, disease duration 9.5 years, median baseline DAS28-CRP 1.9 (IQR 1.6–2.2) and vdHSS 16.0 (IQR 7.0–36.0) were included in the study; 59 (59%) patients from the original MRI treat-to-target group and 72 (72%) from the conventional group. At year 5, 47 patients (80%) in the MRI treat-to-target group vs 54 patients (75%) in the conventional treat-to-target group were in DAS28-CRP remission (OR 2.00 (95% CI 0.76 to 5.28); p=0.16) while 14 patients (24%) vs 19 patients (26%) had no radiographic progression (OR 0.70, (95% CI 0.28 to 1.71); p=0.43).

Conclusion

A 2-year combined MRI and clinical treat-to-target strategy, compared with a conventional clinical treat-to-target strategy alone, had no effect on the long-term probability of achieving DAS28-CRP remission and of avoiding radiographic progression.
Tracing the lead source of maiolica: a pilot isotopic study on artefacts from the area of Florence, Italy (fifteenth–nineteenth century)
Authors: Paghi Diletta , Manca Rosarosa , Casalini Martina , Chiarantini Laura , Bragagni Alessandro , Tommasini Simone , Benvenuti Marco
Published: March 2024

The manufacturing of Italian maiolica (tin-glazed pottery) was extremely appreciated during the Middle Ages and Renaissance, leading to the production and collection of a rich cultural heritage. This pilot study aims to characterize the production technique and the origin of the lead used as a flux in a set of samples of maiolica glazes made in the area of Florence over a wide time span, ranging from the fifteenth to the nineteenth century. In particular, this is the first study that applies provenance analysis, using lead isotopes, to tin-glazed artefacts made in the site of Montelupo Fiorentino and by the Ginori manufactory in Doccia (Florence, Italy), both important production centres of ceramics in Italy. The samples were first analysed by scanning electron microscopy to characterize their layer structure and chemical composition. Lead isotope analysis was then performed by thermal ionization mass spectrometry and showed that the samples tend to be distributed into distinct groups according to their period of production. Moreover, the comparison with the lead isotope composition of the deposits of the European and circum-Mediterranean area from which lead was historically extracted showed that the isotopic composition of the samples differs from that of the Italian deposits, suggesting that lead was imported from abroad. The isotopic composition of all the investigated maiolica glazes is compatible with German ore deposits, in agreement with what is reported by the historical sources relating to the lead supply areas.
Synthesis, characterization and properties of Cr-doped ZnO nanoparticles via a facile solvothermal route
Authors: Devi L. Renuga , Esakki E. Selva , Sundar S. Meenakshi
Published: March 2024

Cr-doped ZnO ([Formula: see text]–0.08) nanoparticles are synthesized using the microwave solvothermal irradiation technique. The final product is calcinated at 450∘C and the nanostructure of the material is investigated using various techniques. In structural studies, XRD analysis shows that the hexagonal wurtzite structure of ZnO is present in the standard JCPDS card. FESEM spectrum reveals the hexagonal shape of the synthesized samples and EDS provides information on the qualitative composition of the nanoparticles. Optical absorbance images show exciton peaks in the UV region, which can be attributed to Cr incorporation into the ZnO lattice, and the optical energy bandgap values are calculated using the tauc plot method. Photoluminescence (PL) emission spectra are measured using PL spectroscopy. Interestingly, vibrating sample magnetometry (VSM) reveals enhancements in the magnetic properties in M–H loops and it is widely used for biological applications like antibacterial activity.
Rolling Bearing Composite Fault Diagnosis Method Based on Convolutional Neural Network
Authors: Chen Song , Guo Dong-ting , Chen Li-ai , Wang Da-gui
Published: March 2024

Rolling bearing feature extraction and fault identification techniques using deep learning algorithms have been widely adopted in recent years. We proposed a method for diagnosing composite faults in rolling bearings by employing multisensor decision fusion and convolutional neural networks. Different types of bearing faults and eccentricity faults have different fault eigenfrequencies in vibration signals. In the proposed method, vibration and acoustic signals are collected, their characteristics are analyzed, and multisensor data fusion processing is conducted. A neural network is then used to identify the signals containing bearing fault characteristics to diagnose bearing faults at different rotational speeds. We demonstrated the effectiveness of the proposed method by conducting comparative experiments on existing methods.
A Synthesis Method of Open-Chain Coupled Serial Linkage Mechanism Fusing Trajectory and Posture
Authors: Zeng Gongjun , Wang Lei , Yu Gaohong , Zheng Mingfeng , Wu Guohuan , Ye Bingliang
Published: March 2024

In order to meet the motion characteristics requirements of multi-objective fusion of execution components, a synthesis method of open-chain coupled serial linkage mechanism fusing trajectory and posture is proposed. According to periodic change characteristics of the execution component trajectory and posture of the linkage mechanism, the motion characteristics equation including trajectory and posture information is established by using Fourier series. The harmonic parameters of the link trajectory and posture are calculated according to the principle of discrete Fourier transform. The complex vector theory is applied to determine the functional relationship between the harmonic parameters of the trajectory and posture and the independent variable of the linkage mechanism, and furthermore the motion synthesis equation of the open-chain linkage mechanism fusing trajectory and posture information is established. The linkage mechanism parameters are calculated using Mathcad Prime software. The single-degree-of-freedom open-chain coupled serial linkage mechanism fusing trajectory and posture information is obtained by using a noncircular gear planetary gear train to couple the connection points of the linkage mechanism. The correctness of the method is verified through an example.
A Fast Adaptive Millimeter-Wave Radar Clustering Algorithm
Authors: Sang Yingjun , Teng Teng , Yu Qingyuan , Hong Haojie , Jin Feng , Fan Yuanyuan
Published: March 2024

This paper focuses on the intelligent recognition problem of radar detection targets. Aiming at the low accuracy and slow speed of millimeter-wave radar clustering point cloud information, a feature algorithm of millimeter-wave radar suitable for detecting targets is proposed. In the detection of targets by millimeter-wave radar, distance is the biggest factor affecting the number and degree of sparsity. A method that combines the feature information of the point cloud with the KD tree proximity search algorithm and the DBSCAN clustering algorithm is proposed, which can adapt to the problems of uneven target point cloud, small amount of data and slow clustering speed. The improved algorithm can use the KD tree to quickly find adjacent points and calculate the distance between adjacent points. The corresponding number of thresholds is set according to the distance where the target is located, and the radius of the target area reflected by the millimeter-wave radar plus the distance of the last threshold point is used as the neighborhood radius of the improved algorithm. Therefore, fast and adaptive parameter adjustment of the millimeter-wave radar can be realized. Simulation tests show that the improved clustering algorithm has better parameters. The accuracy of the improved algorithm is increased by 4.2%, and it also greatly improves the clustering speed.
Test Method of a Rotating-Arm Axis Box Considering Suspension Parameters
Authors: Zou Hua , Song Zhen , Yin Zhenkun
Published: March 2024

With the rotating-arm axis box as the research object, we established a test method in the original place of damage of the axis box that can reproduce the suspension parameter conditions of the bogie frame. First, this method establishes a real axis box mechanical model based on the suspension parameters of the axis box assembly conditions and calculates the load distribution relationship of the axis box through this model. Second, through a comparison of test data under different tooling conditions, it was verified that the distribution relationship had a great influence on the strength evaluation of the axis box body. Then, the single-axis box test method was simulated and optimized to determine the distribution of test loads and constraint conditions. The calculation results better restored the axis box test data under in situ conditions and derived a single-axis box test method with high accuracy. The lowest damage coverage was 1.01. The mechanical modeling and test optimization approach not only improves damage-based life assessment but also tunes up the efficiency of axis box testing.
A lower bound estimate of life span of solutions to stochastic 3D Navier–Stokes equations with convolution-type noise
Authors: Liang Siyu
Published: March 2024

In this paper, we investigate the stochastic 3D Navier–Stokes equations perturbed by linear multiplicative Gaussian noise of convolution type by transformation to random PDEs. We focus on obtaining bounds from below for the life span associated with regular initial data. The key point of the proof is the fixed point argument.
Board Gender Diversity, Governance, and Firm Value: An International Evidence
Authors: Zagorchev Andrey
Published: March 2024

Using firms across 95 countries, the paper finds that a higher percentage of females on the boards is associated with better corporate governance practices concerning the proportion of independent directors, governance disclosure, employee Corporate Social Responsibility (CSR) training, existence of a CSR committee, and board age diversity. Propensity score matching finds that a higher representation of females on the boards can improve board independence, disclosure, CSR training, and firm value. Based on instrumental variable analysis, the findings show that more female directors positively and significantly affect the board age diversity, independent directors, governance disclosure (with GDI annual), and market value.
A High-Resolution Exponential Spline Method and Its Convergence Analysis for Two-Point Mixed Boundary Value Problems
Authors: Sharma Sachin , Kaur Kirandeep
Published: March 2024

In this paper, we present a new numerical method for effectively solving general second-order ordinary differential equations with mixed boundary conditions. Our approach utilizes a quasi-variable mesh enabling us the flexibility to adapt the mesh density according to different boundary layer problems. By employing a discretization technique that incorporates the construction of exponential spline, we achieve third-order accuracy at internal grid points, while boundary points exhibit fourth-order accuracy. Since the method is based on off-step grid points, it eliminates the need to modify the method while employing it to singular problems. We provide computational results to various numerical problems which arise in different physical phenomena like Burger’s equation and Sturm–Liouville equation. A comparison with recent findings underscores the superior performance of our method.
EVs Adoption in Alternative Business Models (ABMs): Psychological Perspective and Empirical Analysis of Indian Customers
Authors: Shalender Kumar
Published: March 2024

Electric Vehicles (EVs) are prominent for achieving sustainable mobility in the future. By drawing on extant literature, we propose a conceptual framework and develop hypotheses based on Novelty seeking (NS), Perceived Behavior Control (PBC), Openness to new Experience (ONE), Risk appetite (RA), and Adoption Intention (AI) of consumers in ABMs. The analysis of data reveals that both NS and PBC are positively related to the ONE which, in turn, impacts the AI of EVs in ABMs in a significantly positive manner. The study also proves that RA moderates the relationship between ONE and AI in such a manner that a higher level of RA makes the relationship between ONE and AI stronger. We contribute to the literature on sustainable mobility by exploring the role of psychological factors in determining AI of Indian customers towards EVs in ABMs and the study has important implications for researchers, practitioners, and policymakers.
Level of self-efficacy among skill-based allied health students in the University of Santo Tomas-Enriched Virtual Mode of learning: A cross-sectional study
Authors: Manlapaz Donald G. , Versales Cristine Rose S. , Pazcoguin John Micko A. , Ching Justin Jeremiah A. , Bartolome Marcela Joyce P. , Da Silva Samantha Lavin , Edquila Kertlouie Gabriel Z. , Francheska Fulo Lara , Benezet J. Male Yvonne Geisel , Patricia Y. Peña Joey , Miguel C. Pineda Ramon
Published: March 2024

Background: Self-efficacy expresses a learner’s perception of how well they can do in the online academic setting. Although students’ academic successes can be measured by online learning self-efficacy, there is a scarcity of evidence targeted toward allied health students.

Objective: The primary aim of this study is to determine the level of online self-efficacy among students from skill-based allied health programs. The secondary aim is to correlate online self-efficacy with age, sex, year level, and program of the students.

Methods: This cross-sectional analytic study utilized the Online Learning Self-Efficacy Scale (OLSE) to determine students’ level of self-efficacy via a survey conducted with students who underwent the Enriched Virtual Mode of learning. Descriptive statistics was used to characterize the study participants, describe the level of self-efficacy, and compare the subscales of OLSE. Inferential statistics using Spearman’s rho was performed to determine the correlation.

Results: A total of 117 respondents with a mean age ± SD of 20.59 ± 0.11 years old, predominantly female (71%) were included in the study. The students from allied health programs had an online self-efficacy overall mean score of 3.83 ([Formula: see text]; range 2.64–5.00) with the use of technology subscales weighted the highest mean score (4.24). Females have a higher average OLSE score ([Formula: see text], [Formula: see text]) compared to males. Significant correlation was found between OLSE scores to sex ([Formula: see text], [Formula: see text]) and year level ([Formula: see text], [Formula: see text]) while nonsignificant correlation was found between OLSE scores to the program ([Formula: see text], [Formula: see text]) and age ([Formula: see text], [Formula: see text]).

Conclusion: Students of allied health programs generally have a very good level of online self-efficacy. This study assists educators in developing proactive strategies and approaches to promote students’ self-confidence across all domains and encourage them to adopt a dynamic remote learning-based approach. Educational institutions should use this opportunity to assess how well they have implemented remote learning to ensure educational continuity, especially in times of crisis.
Laplacian coefficients, Kirchhoff index and the number of spanning trees of graphs
Authors: Bozkurt Altındağ Ş. B. , Milovanović I. , Milovanović E.
Published: March 2024

Let [Formula: see text], [Formula: see text], be a simple connected graph of order [Formula: see text] and size [Formula: see text]. Denote with [Formula: see text] eigenvalues of the Laplacian matrix [Formula: see text] of [Formula: see text]. The Kirchhoff index and the number of spanning trees of [Formula: see text] expressed in terms of Laplacian eigenvalues are given by [Formula: see text] and [Formula: see text], respectively. The characteristic polynomial of [Formula: see text] is given by [Formula: see text]. The first five Laplacian coefficients have been computed in the literature. In this study, we compute the sixth Laplacian coefficient of [Formula: see text]. Then, we use it to improve the previously obtained results on [Formula: see text] and [Formula: see text]. In addition, we present new Nordhaus–Gaddum-type inequalities for [Formula: see text] and [Formula: see text].
Suppression of Multi-Harmonic Currents in the High-Speed Magnetically Suspended Motor Based on Adaptive Cascaded Notch Filters with Variable Phase Angle
Authors: Wang Xianzhang , Xu Xiangbo , Chen Shao , Zheng Lingbo , Li Junfeng , Li Bolun
Published: March 2024

Rotor imbalance is identified as one of the predominant vibration sources in high-speed magnetically suspended motors. Due to factors such as rotor machining accuracy errors and uneven material distribution, synchronous vibration interference is caused. Moreover, sensor runout generates harmonic currents, which are attributed to material irregularities and inhomogeneity in the roundness of the sensor detection surface. Harmonic currents can generate harmonic vibrational forces that are transmitted to the motor housing, jeopardizing control accuracy and the device’s operational lifespan. In order to achieve real-time reduction of harmonic currents at specified frequencies and improve the accuracy of harmonic suppression, this paper proposes an algorithm for variable phase angle filtering of an adaptive cascaded mode notch filter. This paper performed dynamic modeling and analysis of the magnetically suspended rotor system with rotor imbalance and verified the correctness of the dynamic model. Subsequently, the structure of an adaptive notch filter with variable phase angle is introduced, highlighting the capability to maintain stability by adjusting the compensatory phase of the system. By comparing the harmonic current suppression performance of cascaded and parallel mode notch filters, the cascaded method can better enhance the overall frequency selectivity, emphasizing its ability to adjust the compensation phase based on the phase angle of the input signal at different frequencies to maintain system stability. Simulation and experimental results show that harmonic currents can be successfully suppressed in the cascade mode, and the amplitude of the synchronous frequency current is reduced by 94.4%.
Multi-grained Document Modeling for Search Result Diversification
Authors: Deng Zhirui , Dou Zhicheng , Su Zhan , Wen Ji-Rong
Published: March 2024

Search result diversification plays a crucial role in improving users’ search experience by providing users with documents covering more subtopics. Previous studies have made great progress in leveraging inter-document interactions to measure the similarity among documents. However, different parts of the document may embody different subtopics and existing models ignore the subtle similarities and differences of content within each document. In this article, we propose a hierarchical attention framework to combine intra-document interactions with inter-document interactions in a complementary manner in order to conduct multi-grained document modeling. Specifically, we separate the document into passages to model the document content from multi-grained perspectives. Then, we design stacked interaction blocks to conduct inter-document and intra-document interactions. Moreover, to measure the subtopic coverage of each document more accurately, we propose a passage-aware document-subtopic interaction to perform fine-grained document-subtopic interaction. Experimental results demonstrate that our model achieves state-of-the-art performance compared with existing methods.
Breakdown up to 13.5 kV in NiO/β-Ga2O3 Vertical Heterojunction Rectifiers
Authors: Li Jian-Sian , Wan Hsiao-Hsuan , Chiang Chao-Ching , Yoo Timothy Jinsoo , Yu Meng-Hsun , Ren Fan , Kim Honggyu , Liao Yu-Te , Pearton Stephen J.
Published: March 2024

Vertical heterojunction NiO/β n-Ga2O/n+ Ga2O3 rectifiers with 100 μm diameter fabricated on ∼17–18 μm thick drift layers with carrier concentration 8.8 × 1015 cm−3 and employing simple dual-layer PECVD SiNx/SiO2 edge termination demonstrate breakdown voltages (VB) up to 13.5 kV, on-voltage (VON) of ∼2.2 V and on-state resistance RON of 11.1–12 mΩ.cm2. Without edge termination, the maximum VB was 7.9 kV. The average critical breakdown field in heterojunctions was ∼7.4–9.4 MV. cm−1, within the reported theoretical value range from 8–15 MV.cm−1 for β-Ga2O3. For large area (1 mm diameter) heterojunction deives, the maximum VB was 7.2 kV with optimized edge termination and 3.9 kV without edge termination. The associated maximum power figure-of-merit, VB
2/RON is 15.2 GW·cm−2 for small area devices and 0.65 GW.cm−2 for large area devices. By sharp contrast, small area Schottky rectifiers concurrently fabricated on the same drift layers had maximum VB of 3.6 kV with edge termination and 2.7 kV without edge termination, but lower VON of 0.71–0.75 V. The average critical breakdown field in these devices was in the range 1.9–2.7 MV. cm−1, showing the importance of both the heterojunction and edge termination. Transmission electron microscopy showed an absence of lattice damage between the PECVD and sputtered films within the device and the underlying epitaxial Ga2O3. The key advances are thicker, lower doped drift layers and optimization of edge termination design and deposition processes.
Surgically induced aortic coarctation in a neonatal porcine model allows for longitudinal assessment of cardiovascular changes
Authors: Stellon Michael , Gober Leah , Culver Matthew Allen , Hermsen Joshua , Irrer Dana , Witzenburg Colleen , Roldán-Alzate Alejandro , Lamers Luke
Published: March 2024

A neonatal model of aortic coarctation was developed in a porcine model using a readily reproducible method of aortic plication and external wrap placement. This model addresses the limitations of existing models including neonatal stenosis creation, appropriate anatomic location of the stenosis, and intimal injury creation and mimics human somatic growth. Pigs met American Heart Association (AHA) criteria for consideration of intervention, and the stenoses were graded as moderate to severe.
A Second-Order Finite-Difference Method for Derivative-Free Optimization
Authors: Chen Qian , Wang Peng , Zhu Detong
Published: March 2024

In this paper, a second-order finite-difference method is proposed for finding the second-order stationary point of derivative-free nonconvex unconstrained optimization problems. The forward-difference or the central-difference technique is used to approximate the gradient and Hessian matrix of objective function, respectively. The traditional trust-region framework is used, and we minimize the approximation trust region subproblem to obtain the search direction. The global convergence of the algorithm is given without the fully quadratic assumption. Numerical results show the effectiveness of the algorithm using the forward-difference and central-difference approximations.
Effect of Semolina Replacement with Amaranth Flour on Quality Characteristics of Functional Pasta
Authors: Alizadeh Sogand , Ahmadi-Dastgerdi Asiye , Reisi Sara , Ebrahimi Tirtashi Fahimeh , Zokaei Maryam , Tahriri Shiva
Published: March 2024

Amaranth is one of the gluten-free pseudocereals and is suitable for celiac disease. This research aimed to investigate the effect of amaranth flour in concentrations of 0 (C), 10 (A10), 15 (A15), and 20% (A20) on the rheological, physicochemical, and sensory characteristics of functional pasta during 3 months. The prepared pasta was analyzed for its quality characteristics such as chemical composition, cooking loss, texture, color, and amylose leach out and was subjected to farinograph and extensograph tests and scanning electron microscopy (SEM). The results showed that the addition of amaranth flour weakens the rheological characteristics of pasta dough. Amaranth flour had a significant effect on the physicochemical properties of pasta (p<0.05). The lowest moisture content, fat, protein, and fiber were observed in the control sample, and the highest amounts were observed in the A20 sample. The moisture content decreased during storage. The control and A20 samples recorded the lowest and highest cooking loss, respectively. The addition of amaranth decreased the hardness, lightness (L), and yellowness (b∗) and increased the redness (a∗) of pasta. The amylose leach out in the cooking water of all amaranth pasta ranged from 2.03 g to 3.38 g/100 g which was lower than that of the control (4.95 g/100 g). The structure of control pasta is an interwoven network of gluten with many holes and swollen starch granules. A more uniform structure with fewer holes and a looser gluten network was observed in the microstructure of amaranth pasta. A10 treatment obtained the highest score of sensory evaluation. In conclusion, the amaranth flour has a good potential to be used in functional foods and gluten-free pasta. A20 was favorable in terms of physicochemical characteristics, and A10 was the best in terms of sensory characteristics.
Simulation-Based Analysis of Trial Design in Regional Anesthesia
Authors: Pasli Melisa , Tumin Dmitry , Guffey Ryan
Published: March 2024

Background. In regional anesthesia, the efficacy of novel blocks is typically evaluated using randomized controlled trials (RCTs), the findings of which are aggregated in systematic reviews and meta-analyses. Systematic review authors frequently point out the small sample size of RCTs as limiting conclusions from this literature. We sought to determine via statistical simulation if small sample size could be an expected property of RCTs focusing on novel blocks with typical effect sizes. Methods. We simulated the conduct of a series of RCTs comparing a novel block versus placebo on a single continuous outcome measure. Simulation analysis inputs were obtained from a systematic bibliographic search of meta-analyses. Primary outcomes were the predicted number of large trials (empirically defined as N ≥ 256) and total patient enrollment. Results. Simulation analysis predicted that a novel block would be tested in 16 RCTs enrolling a median of 970 patients (interquartile range (IQR) across 1000 simulations: 806, 1269), with no large trials. Among possible modifications to trial design, decreasing the statistical significance threshold from p<0.05 to p<0.005 was most effective at increasing the total number of patients represented in the final meta-analysis, but was associated with early termination of the trial sequence due to futility in block vs. block comparisons. Conclusion. Small sample size of regional anesthesia RCTs comparing novel block to placebo is a rational outcome of trial design. Feasibly large trials are unlikely to change conclusions regarding block vs. placebo comparisons.
Supplementary Data from Targeting Ferroptosis-Elicited Inflammation Suppresses Hepatocellular Carcinoma Metastasis and Enhances Sorafenib Efficacy
Authors: Mu Ming , Huang Chun-Xiang , Qu Chuang , Li Pei-Lin , Wu Xiang-Ning , Yao Wudexin , Shen Chu , Huang Rucheng , Wan Chao-Chao , Jian Zhi-Wei , Zheng Limin , Wu Rui-Qi , Lao Xiang-Ming , Kuang Dong-Ming
Published: March 2024

Supplementary Figures and Tables
Supplementary Data from A Benzarone Derivative Inhibits EYA to Suppress Tumor Growth in SHH Medulloblastoma
Authors: Hwang Grace H. , Pazyra-Murphy Maria F. , Seo Hyuk-Soo , Dhe-Paganon Sirano , Stopka Sylwia A. , DiPiazza Marina , Sutter Nizhoni , Gero Thomas W. , Volkert Alison , Ombelets Lincoln , Dittemore Georgia , Rees Matthew G. , Ronan Melissa M. , Roth Jennifer A. , Agar Nathalie Y.R. , Scott David A. , Segal Rosalind A.
Published: March 2024

Supplemental Methods and Figure Legends
Supplemental Table 6 from A Benzarone Derivative Inhibits EYA to Suppress Tumor Growth in SHH Medulloblastoma
Authors: Hwang Grace H. , Pazyra-Murphy Maria F. , Seo Hyuk-Soo , Dhe-Paganon Sirano , Stopka Sylwia A. , DiPiazza Marina , Sutter Nizhoni , Gero Thomas W. , Volkert Alison , Ombelets Lincoln , Dittemore Georgia , Rees Matthew G. , Ronan Melissa M. , Roth Jennifer A. , Agar Nathalie Y.R. , Scott David A. , Segal Rosalind A.
Published: March 2024

Supplemental Table 6
Supplementary Tables S1-S4 from AKT1 interacts with DHX9 to Mitigate R Loop–Induced Replication Stress in Ovarian Cancer
Authors: Huang Tzu-Ting , Chiang Chih-Yuan , Nair Jayakumar R. , Wilson Kelli M. , Cheng Ken , Lee Jung-Min
Published: March 2024

Tables S1-S4
Figure S13 from N6-Methyladenosine Reader YTHDF1 Promotes Stemness and Therapeutic Resistance in Hepatocellular Carcinoma by Enhancing NOTCH1 Expression
Authors: Zhang Xinyue , Su Tianhong , Wu Yifan , Cai Yuhong , Wang Lina , Liang Cong , Zhou Lei , Wang Shiyan , Li Xiao-Xing , Peng Sui , Kuang Ming , Yu Jun , Xu Lixia
Published: March 2024

Figure S13
Data from Post-translational Modification of PD-1: Potential Targets for Cancer Immunotherapy
Authors: Lee Te-An , Tsai En-Yun , Liu Shou-Hou , Hsu Hung Shih-Duo , Chang Shing-Jyh , Chao Chi-Hong , Lai Yun-Ju , Yamaguchi Hirohito , Li Chia-Wei
Published: March 2024

Abstract
Activation of effector T cells leads to upregulation of PD-1, which can inhibit T-cell activity following engagement with its ligand PD-L1. Post-translational modifications (PTM), including glycosylation, phosphorylation, ubiquitination, and palmitoylation, play a significant role in regulating PD-1 protein stability, localization, and interprotein interactions. Targeting PTM of PD-1 in T cells has emerged as a potential strategy to overcome PD-1–mediated immunosuppression in cancer and enhances antitumor immunity. The regulatory signaling pathways that induce PTM of PD-1 can be suppressed with small-molecule inhibitors, and mAbs can directly target PD-1 PTMs. Preliminary outcomes from exploratory studies suggest that focusing on the PTM of PD-1 has strong therapeutic potential and can enhance the response to anti-PD-1.
FASN Inhibition Decreases MHC-I Degradation and Synergizes with PD-L1 Checkpoint Blockade in Hepatocellular Carcinoma
Authors: Huang Jiao , Tsang Wai Ying , Fang Xiao-Na , Zhang Yu , Luo Jie , Gong Lan-Qi , Zhang Bai-Feng , Wong Ching Ngar , Li Zhi-Hong , Liu Bei-Lei , Huang Jin-Lin , Yang Yu-Ma , Liu Shan , Ban Liu-Xian , Chan Yiu Hong , Guan Xin-Yuan
Published: March 2024

Immune checkpoint inhibitors (ICI) transformed the treatment landscape of hepatocellular carcinoma (HCC). Unfortunately, patients with attenuated MHC-I expression remain refractory to ICIs, and druggable targets for upregulating MHC-I are limited. Here, we found that genetic or pharmacologic inhibition of fatty acid synthase (FASN) increased MHC-I levels in HCC cells, promoting antigen presentation and stimulating antigen-specific CD8+ T-cell cytotoxicity. Mechanistically, FASN inhibition reduced palmitoylation of MHC-I that led to its lysosomal degradation. The palmitoyltransferase DHHC3 directly bound MHC-I and negatively regulated MHC-I protein levels. In an orthotopic HCC mouse model, Fasn deficiency enhanced MHC-I levels and promoted cancer cell killing by tumor-infiltrating CD8+ T cells. Moreover, the combination of two different FASN inhibitors, orlistat and TVB-2640, with anti–PD-L1 antibody robustly suppressed tumor growth in vivo. Multiplex IHC of human HCC samples and bioinformatic analysis of The Cancer Genome Atlas data further illustrated that lower expression of FASN was correlated with a higher percentage of cytotoxic CD8+ T cells. The identification of FASN as a negative regulator of MHC-I provides the rationale for combining FASN inhibitors and immunotherapy for treating HCC.

Significance:

Inhibition of FASN increases MHC-I protein levels by suppressing its palmitoylation and lysosomal degradation, which stimulates immune activity against hepatocellular carcinoma and enhances the efficacy of immune checkpoint inhibition.
Supplementary Table S2 from Phase I Study of ORIC-101, a Glucocorticoid Receptor Antagonist, in Combination with Enzalutamide in Patients with Metastatic Castration-resistant Prostate Cancer Progressing on Enzalutamide
Authors: Abida Wassim , Hahn Andrew W. , Shore Neal , Agarwal Neeraj , Sieber Paul , Smith Matthew R. , Dorff Tanya , Monk Paul , Rettig Matthew , Patel Rupal , Page Anne , Duff Maureen , Xu Rongda , Wang Jian , Barkund Shravani , Pankov Aleksandr , Wang Amber , Junttila Melissa R. , Multani Pratik S. , Daemen Anneleen , Chow Maneval Edna , Logothetis Christopher J. , Morris Michael J.
Published: March 2024

Supplementary Table 2.ctDNA Data for 29 and cfRNA Data for 26 Patients in Dose
Supplementary Table S1 from Phase I Study of ORIC-101, a Glucocorticoid Receptor Antagonist, in Combination with Enzalutamide in Patients with Metastatic Castration-resistant Prostate Cancer Progressing on Enzalutamide
Authors: Abida Wassim , Hahn Andrew W. , Shore Neal , Agarwal Neeraj , Sieber Paul , Smith Matthew R. , Dorff Tanya , Monk Paul , Rettig Matthew , Patel Rupal , Page Anne , Duff Maureen , Xu Rongda , Wang Jian , Barkund Shravani , Pankov Aleksandr , Wang Amber , Junttila Melissa R. , Multani Pratik S. , Daemen Anneleen , Chow Maneval Edna , Logothetis Christopher J. , Morris Michael J.
Published: March 2024

Supplementary Table 1. Representativeness of Study Participants
Supplementary Table S9 from Preclinical Evaluation of NTX-301, a Novel DNA Hypomethylating Agent in Ovarian Cancer
Authors: Wang Yinu , Situ Xiaolei , Cardenas Horacio , Siu Ellie , Alhunayan Sayedabdulrazzaq A. , Keathley Russell , Tanner Edward , Wei Jian-Jun , Tan Yuying , Prabhu Dessai Chinmayee Vallabh , Cheng Ji-Xin , Matei Daniela
Published: March 2024

Top 30 gene with decreased methylation level in OVCAR5 cells treated with NTX301 compared to DMSO.
Supplementary Table S8 from Preclinical Evaluation of NTX-301, a Novel DNA Hypomethylating Agent in Ovarian Cancer
Authors: Wang Yinu , Situ Xiaolei , Cardenas Horacio , Siu Ellie , Alhunayan Sayedabdulrazzaq A. , Keathley Russell , Tanner Edward , Wei Jian-Jun , Tan Yuying , Prabhu Dessai Chinmayee Vallabh , Cheng Ji-Xin , Matei Daniela
Published: March 2024

Supplemental Table S8. Top 30 gene with increased methylation level in OVCAR5 cells treated with NTX301 compared to DMSO.
Supplementary Table S5 from Preclinical Evaluation of NTX-301, a Novel DNA Hypomethylating Agent in Ovarian Cancer
Authors: Wang Yinu , Situ Xiaolei , Cardenas Horacio , Siu Ellie , Alhunayan Sayedabdulrazzaq A. , Keathley Russell , Tanner Edward , Wei Jian-Jun , Tan Yuying , Prabhu Dessai Chinmayee Vallabh , Cheng Ji-Xin , Matei Daniela
Published: March 2024

Top 30 downregulated DEGs in OVCAR5 cells treated with NTX301 compared to DMSO.
Supplementary Figure S2 from Preclinical Evaluation of NTX-301, a Novel DNA Hypomethylating Agent in Ovarian Cancer
Authors: Wang Yinu , Situ Xiaolei , Cardenas Horacio , Siu Ellie , Alhunayan Sayedabdulrazzaq A. , Keathley Russell , Tanner Edward , Wei Jian-Jun , Tan Yuying , Prabhu Dessai Chinmayee Vallabh , Cheng Ji-Xin , Matei Daniela
Published: March 2024

NTX301 induced transcriptome and methylome reprogramming in OC cells.
Table S4 from Hypoxia-Induced Neuronal Activity in Glioma Patients Polarizes Microglia by Potentiating RNA m6A Demethylation
Authors: Guo Xiaofan , Qiu Wei , Li Boyan , Qi Yanhua , Wang Shaobo , Zhao Rongrong , Cheng Bo , Han Xiao , Du Hao , Pan Ziwen , Zhao Shulin , Qiu Jiawei , Li Gang , Xue Hao
Published: March 2024

Table S4. Antibodies used.
Figure S8 from Hypoxia-Induced Neuronal Activity in Glioma Patients Polarizes Microglia by Potentiating RNA m6A Demethylation
Authors: Guo Xiaofan , Qiu Wei , Li Boyan , Qi Yanhua , Wang Shaobo , Zhao Rongrong , Cheng Bo , Han Xiao , Du Hao , Pan Ziwen , Zhao Shulin , Qiu Jiawei , Li Gang , Xue Hao
Published: March 2024

Figure S8. miR-200c-3p promotes the M2 polarization of microglia in vitro.
Figure S13 from Hypoxia-Induced Neuronal Activity in Glioma Patients Polarizes Microglia by Potentiating RNA m6A Demethylation
Authors: Guo Xiaofan , Qiu Wei , Li Boyan , Qi Yanhua , Wang Shaobo , Zhao Rongrong , Cheng Bo , Han Xiao , Du Hao , Pan Ziwen , Zhao Shulin , Qiu Jiawei , Li Gang , Xue Hao
Published: March 2024

Figure S13. A-NDEs promote microglial M2 polarization via the miR-200c-3p/ZC3H13/DUSP9/ERK pathway.
Figure S1 from Hypoxia-Induced Neuronal Activity in Glioma Patients Polarizes Microglia by Potentiating RNA m6A Demethylation
Authors: Guo Xiaofan , Qiu Wei , Li Boyan , Qi Yanhua , Wang Shaobo , Zhao Rongrong , Cheng Bo , Han Xiao , Du Hao , Pan Ziwen , Zhao Shulin , Qiu Jiawei , Li Gang , Xue Hao
Published: March 2024

Figure S1. Hypoxia drives glioma stem cells to activate neurons via glutamate.
Supplementary Table S5 from Phase II Study of Durvalumab Immediately after Completion of Chemoradiotherapy in Unresectable Stage III Non–small Cell Lung Cancer: TORG1937 (DATE Study)
Authors: Nakamichi Shinji , Kubota Kaoru , Misumi Toshihiro , Kondo Tetsuro , Murakami Shuji , Shiraishi Yoshimasa , Imai Hisao , Harada Daijiro , Isobe Kazutoshi , Itani Hidetoshi , Takata Saori , Wakui Hiroshi , Misumi Yuki , Ikeda Satoshi , Asao Tetsuhiko , Furuya Naoki , Hosokawa Shinobu , Kobayashi Yumiko , Takiguchi Yuichi , Okamoto Hiroaki
Published: March 2024

Summary of the efficacy and safety between this study and the previous studies
Supplementary Table S4 from Characterization of Immunosuppressive Myeloid Cells in Merkel Cell Carcinoma: Correlation with Resistance to PD-1 Pathway Blockade
Authors: Tabachnick-Cherny Shira , Pulliam Thomas , Rodriguez Haroldo J. , Fan Xinyi , Hippe Daniel S. , Jones Daniel C. , Moshiri Ata S. , Smythe Kimberly S. , Kulikauskas Rima M. , Zaba Lisa C. , Paulson Kelly G. , Nghiem Paul
Published: March 2024

MNP and M-MDSC gene signatures used for myeloid clusters validation
Supplementary Figure S8 from Characterization of Immunosuppressive Myeloid Cells in Merkel Cell Carcinoma: Correlation with Resistance to PD-1 Pathway Blockade
Authors: Tabachnick-Cherny Shira , Pulliam Thomas , Rodriguez Haroldo J. , Fan Xinyi , Hippe Daniel S. , Jones Daniel C. , Moshiri Ata S. , Smythe Kimberly S. , Kulikauskas Rima M. , Zaba Lisa C. , Paulson Kelly G. , Nghiem Paul
Published: March 2024

Higher levels of S100A8 expressing cells relative to CD8 T cells in responding MCC tumors are associated with shorter duration of response.
Supplementary Figure S1 from Characterization of Immunosuppressive Myeloid Cells in Merkel Cell Carcinoma: Correlation with Resistance to PD-1 Pathway Blockade
Authors: Tabachnick-Cherny Shira , Pulliam Thomas , Rodriguez Haroldo J. , Fan Xinyi , Hippe Daniel S. , Jones Daniel C. , Moshiri Ata S. , Smythe Kimberly S. , Kulikauskas Rima M. , Zaba Lisa C. , Paulson Kelly G. , Nghiem Paul
Published: March 2024

Signature expression of MNP universal genes and selected M-MDSC genes among all identified clusters.
Figure S8 from Nanoparticle-mediated Photodynamic Therapy as a Method to Ablate Oral Cavity Squamous Cell Carcinoma in Preclinical Models
Authors: Sahovaler Axel , Valic Michael S. , Townson Jason L. , Chan Harley H.L. , Zheng Mark , Tzelnick Sharon , Mondello Tiziana , Pener-Tessler Alon , Eu Donovan , El-Sayes Abdullah , Ding Lili , Chen Juan , Douglas Catriona M. , Weersink Robert , Muhanna Nidal , Zheng Gang , Irish Jonathan C.
Published: March 2024

Supplementary figure 8 and legend.
Figure S5 from Nanoparticle-mediated Photodynamic Therapy as a Method to Ablate Oral Cavity Squamous Cell Carcinoma in Preclinical Models
Authors: Sahovaler Axel , Valic Michael S. , Townson Jason L. , Chan Harley H.L. , Zheng Mark , Tzelnick Sharon , Mondello Tiziana , Pener-Tessler Alon , Eu Donovan , El-Sayes Abdullah , Ding Lili , Chen Juan , Douglas Catriona M. , Weersink Robert , Muhanna Nidal , Zheng Gang , Irish Jonathan C.
Published: March 2024

Supplementary figure 5 and legend.
Figure S3 from Nanoparticle-mediated Photodynamic Therapy as a Method to Ablate Oral Cavity Squamous Cell Carcinoma in Preclinical Models
Authors: Sahovaler Axel , Valic Michael S. , Townson Jason L. , Chan Harley H.L. , Zheng Mark , Tzelnick Sharon , Mondello Tiziana , Pener-Tessler Alon , Eu Donovan , El-Sayes Abdullah , Ding Lili , Chen Juan , Douglas Catriona M. , Weersink Robert , Muhanna Nidal , Zheng Gang , Irish Jonathan C.
Published: March 2024

Supplementary figure 3.
Figure S1 from Nanoparticle-mediated Photodynamic Therapy as a Method to Ablate Oral Cavity Squamous Cell Carcinoma in Preclinical Models
Authors: Sahovaler Axel , Valic Michael S. , Townson Jason L. , Chan Harley H.L. , Zheng Mark , Tzelnick Sharon , Mondello Tiziana , Pener-Tessler Alon , Eu Donovan , El-Sayes Abdullah , Ding Lili , Chen Juan , Douglas Catriona M. , Weersink Robert , Muhanna Nidal , Zheng Gang , Irish Jonathan C.
Published: March 2024

Supplementary figure 1 and legend.
FIGURE 6 from Nanoparticle-mediated Photodynamic Therapy as a Method to Ablate Oral Cavity Squamous Cell Carcinoma in Preclinical Models
Authors: Sahovaler Axel , Valic Michael S. , Townson Jason L. , Chan Harley H.L. , Zheng Mark , Tzelnick Sharon , Mondello Tiziana , Pener-Tessler Alon , Eu Donovan , El-Sayes Abdullah , Ding Lili , Chen Juan , Douglas Catriona M. , Weersink Robert , Muhanna Nidal , Zheng Gang , Irish Jonathan C.
Published: March 2024

Antitumor treatment response to PS-PDT (10 mg/kg, 24 hour DLI, 200 J total) in an orthotopic VX-2 rabbit tumor model. A, Overview of “two-step” PDT treatment scheme in rabbits involving first, surface illumination of the tumor through the overlying skin using an external laser beam (100 J/cm2, 100 mW/cm2); and second, interstitial illumination with a diffusing fiber (1 cm, 100 J/cm, 100 mW/cm) inserted into the center of the tumor mass. B, Survival analysis of buccal VX-2 tumors following start of treatment on week 0. Event was tumor volume >3.05 cm3 (humane endpoint). N = 5 tumors (single PS-PDT), 4 tumors (repeat PS-PDT), 3 tumors (drug control), and 3 tumors (light control). Statistics: multiple comparisons of survival curves performed with log-rank tests using Bonferroni correction method for multiple comparison and ⍺ = 0.05. Single PS-PDT versus repeat PS-PDT = ns; Single PS-PDT versus drug control = ns; Single PS-PDT versus light control = *; Repeat PS-PDT versus drug control = *; Repeat PS-PDT versus light control = **. Fold change in tumor volume (C) and representative white light images and CT image reconstructions (D) of orthotopic buccal VX-2 tumors following single PS-PDT treatment on week 0. Fold change in tumor volume (E) and representative white light images and CT image reconstructions (F) following repeat PS-PDT treatments on weeks 0, 1, and 2. For C and E, red arrows indicated occasions of PS-PDT treatment. For D and F, normal anatomy outlined in purple, VX-2 tumor highlighted in green. Images not scaled for size. Additional PS-PDT efficacy data and statistical analysis are provided in Supplementary Table S11.