bluuebunny/crossref_metadata_2025 huggingface dataset:
Forecasting the demand for teacher training to meet the general education program 2018
Authors: Nguyen Vu Bich Hien , Nguyen Van Anh , Vu Thi Mai Huong , Ngo Hoang Long
Published: February 2022

This study analyzes the scientific basis of education forecasting, thereby building a formula and model for forecasting teacher training needs in Vietnam, meeting the requirements of human resources to implement general education program 2018. The results of the forecast of teacher training needs are given according to the forecast year, forecast period for each school level, subject and region across the country. The forecast results are the basis for providing solutions on teacher training such as: renovating teacher training programs, determining enrollment targets, adjusting state management policies on education and planning a network of teacher training institutions nationwide.
Arsenic exposure and its toxicity
Authors: Pratap Singh Shashi , Sharma Shivam
Published: February 2022

Arsenic is a pollutant in the environment, and its poisoning of drinking water is considered a severe global health issue. Chronic arsenic exposure is linked to an increased risk of a variety of diseases, including cardiovascular abnormalities, diabetes mellitus, neurotoxicity, and nephrotoxicity. Furthermore, arsenic exposure has been linked to changes in liver function and the development of hepatotoxicity. Furthermore, only a few studies have shown that persistent exposure to arsenic causes carcinogenesis, particularly cancers of the skin, bladder, and lungs. The current study looks at a variety of processes that play a role in arsenic-induced toxicity and end-organ damage.
Nursing Students’ Perception and Attitude towards Objective Structured Clinical Examination in Oman
Authors: Alamri Shaikha , Al Hashmi Iman , Shruba Kholah , Jamaan Suad , Alrahbi Zaina , Al Kaabi Thuraiya
Published: February 2022

Objectives: This study aimed to explore undergraduate nursing students’ perception and attitude towards the Objective Structured Clinical Examination (OSCE). Methods: This cross-sectional descriptive study was conducted between April–May 2020 among undergraduate nursing students at the College of Nursing at Sultan Qaboos University, Muscat, Oman. Two self-administered questionnaires were utilised to obtain data on students’ perception and attitude towards OSCE. Students’ feedback on OSCE was collected using open-ended questions about OSCE strengths, weaknesses and recommendations for improvement. Survey responses were based on a five-point ordinal scale, ranging from strongly disagree to strongly agree. Students’ feedback on OSCE was analysed as descriptive data by identifying the common themes and categorising them in groups. Results: A total of 160 students completed the study questionnaires. Most did not find the atmosphere of OSCE to be pleasant (66.3%) and preferred more modes of practical examination (40.6%). Moreover, 64.4% believed the time limitation to be inadequate. The data depict that 33.1% of the examinees deemed the OSCE more stressful than the full practical examination. In addition, a few students confirmed that the OSCE improved their communication skills and confidence in nursing skills. Conclusion: The findings of this study appear alarming in regard to students’ perception regarding the overall process and validity of OSCE as an assessment method. Nursing educators must consider further evaluation and improvement of the OSCE in order to improve students’ acceptance and appreciation of OSCE as an important form of clinical learning and assessment.
Keywords: Clinical Competence; Nursing Education; Baccalaureate; Evaluation; Attitude; Nursing Students; Practical Nursing; Oman.
PROBLEMATIKA KONSELING MULTIKULTURAL PADA PELAKSANAN BIMBINGAN KONSELING DI SMP NEGERI 8 REJANG LEBONG
Authors: Kurniaty Desty , Prayetno Aji , Novalia Yefni , H Hartini
Published: February 2022

The importance of multiculturalism counseling because through this personal social guidance individuals can learn to adapt, understand the culture in different environments, and the diversity of cultures that exist. This study discusses the Problems of Multicultural Counseling Case Studies of SMP Negeri 8 Rejang Lebong ". Meanwhile, this type of data uses primary and secondary data with data collection through interviews, observation and documentation. In addition, the data analysis technique used data reduction, data presentation and data verification and continued with checking the validity of the data. The results of the study, namely the form of Problems for students of SMP Negeri 8 Rejang Lebong, are as follows: The difficulty of counselors offering multicultural counseling must be in accordance with the counselee's culture because the reality of the multicultural environment of students becomes a problem for counselors The obstacles in implementing multicultural counseling are: lack of parental cooperation with problem students and lack of participation between teachers and students, cultural differences in students that require BK teachers to understand different student cultures and limited counseling room facilities. Efforts in dealing with multicultural problems are carried out by increasing the implementation of multicultural counseling, increasing collaboration with teachers, parents and utilizing media in multicultural counseling and providing guidance on character values ​​based on religion.
PERAN KONSELING KELUARGA DALAM MENGATASI PERMASALAHAN KELUARGA
Authors: Dewi Rosmala , Azizah Andis , Mareska Susi , Suriyanti Suriyanti , Hartini Hartini
Published: February 2022

In essence, the family is a container that shapes and influences children’s attitudes and character. In forming a harmonious family and able to carry out their responsibilities as a family is not an easy thing, many families are unable to carry out their functions properly. The inability of the family in fostering harmonious relationships will be able to trigger problems in the family. Therefore, counseling provides a solution, namely the existence of a counseling service that is family in nature in finding and creating harmonious and balanced psychological conditions. Family counseling aims to encourage family members to have tolerance, realistic perceptions and be able to motivate and encourage family members. This research is library study, which is a data collecting step, examine and analyze data taken from the written literature that is relevant and related to problems that occur in a family. In this study, the focal point is the role of family counseling in overcoming family problems. Therefore, there are various problems that often arise in families and family counseling is one solution that can solve these problems. Meanwhile, this type of data uses primary and secondary data. In addition, the data analysis used reduction technique, presentation and verification and continued checking data for validity. The study results, the Problems that often arise in a family include sexual problems, education, work, inter and inter-family relations, economics, health, and religious issues. These problems are taken from various expert opinions based on family problems. Therefore, family counseling plays a very important role in helping to solve family problems in finding and creating harmonious and balanced psychological conditions so that families become harmonious and happy and families can carry out their functions properly.
Pemahaman dan Praktik Mahasiswa Terhadap Hadis Isbal: Studi Living Hadis
Authors: Prafitri Amelia , Mugiyono Mugiyono , Almunadi Almunadi
Published: February 2022

Selain dari pada Al-Qur’an, hadis merupakan sumber kedua dalam mengatur berbagai persoalan termasuk tentang berpakaian. Di antara pakaian yang diharamkan bagi laki-laki adalah pakaian yang menjulur sehingga melewati kedua mata kaki (isbal) baik berupa jubah, sarung atau model pakaian lainnya. Dalam hal ini penulis mencoba untuk mengangkat penelitian tentang isbal, yakni pemahaman dan praktik isbal di kalangan mahasiswa Fakultas Teknik Universitas Tridinanti Palembang. Tujuan penelitian ini adalah untuk mengetahui praktik isbal secara langsung yang dilakukan oleh mahasiswa Fakultas Teknik Universitas Tridinanti Palembang. Penelitian ini merupakan penelitian lapangan dengan jenis data kualitatif yang bersifat deskriptif dan data dinyatakan dalam bentuk verbal. Sedangkan teknik analisis data meliputi reduksi data, display dan terakhir verifikasi. Hasil penelitian ini menunjukkan bahwa pemahaman mahasiswa Fakultas Teknik Universitas Tridinanti Palembang terhadap isbal dilakukan bukan karena niat yang sombong, akan tetapi untuk menunjukan kesan yang baik kepada orang lain serta nyamannya dalam berpakaian. Adapun praktik isbal itu sendiri dipengaruhi oleh faktor lingkungan yang sangat mempengaruhi cara seseorang dalam berpakaian, baik dari lingkungan tempat tinggal, lingkungan tetangga di mana tempat responden menetap dan berdomisili, juga tentunya lingkungan pertemanan disekitarnya, sehingga terbentuk cara berpakaian yang disebut isbal.
“El rayo ciego”: un relato en zoque de Ocotepec
Authors:   Centro de Investigaciones y Estudios Superiores en Antropología Social, Mexico, Ramírez Muñoz Ernesto , Hernández García Gregorio ,   Independent, Mexico
Published: February 2022

Among the Zoques of Ocotepec, Chiapas there is a tale, here entitled “The Blind Thunderbolt”, a narration that talks about some animals that want to destroy a mountain full of food and valuable objects. Many animals were called and each one made the attempt to obtain the valuable objects using their abilities. No animal could achieve the goal, so they decided to talk to the Thunderbolt God who, using his stick, made the mountain blow up. The Zoque men of the region were able to get objects and food from the mountain. Depending on what the men from each town got in the mountain, their particular part of the Zoque region continues up to the present to be associated with that object. When men and animals looted the mountain, they did not leave anything to the Thunderbolt except an eagle, that then put his eyes out, blinding the Thunderbolt. Due to such misfortune, the Thunderbolt’s only function now is to warn the humans and animals about the rain. This narrative is a mythological explanation of the particular type of work that each Zoque town does nowadays.
Grümme, Bernhard (2021). Praxeologie. Eine religionspädagogische Selbstaufklärung. Freiburg: Herder Verlag. ISBN 978-3-451-39049-4. 495 Seiten.
Authors: Gärtner Claudia
Published: February 2022

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(Des)Invisibilização
Authors: Lima Luciano Feliciano de
Published: February 2022

O presente texto objetiva refletir sobre o processo escolar de invizibilização de pessoas de orientação sexual diferente da heteronormativa e como ele pode prejudicar, por exemplo, a aprendizagem em Matemática. Sugere-se uma desinvibilização a partir da problematização do preconceito. Transita-se entre os processos de estranhamentos e subjetivações de gênero e sexualidade, a partir de vivências durante a formação regular do autor. Por meio de reminiscências, buscou-se estabelecer um diálogo com literatura que versa sobre uma educação para além de uma inserção no mundo, mas para um questionamento sobre o porquê de as coisas serem, como estão sendo, com a finalidade de contribuir com reflexões para uma possível diminuição de injustiças. Espera-se sensibilizar professores, desde a formação inicial, para um exercício de uma docência mais empática capaz de enxergar todos/as os/as estudantes na sala de aula para oferecer um ambiente respeitoso e acolhedor para o ensino e a aprendizagem.
Mathematics Teachers Educator specialized knowledge model
Authors: Ferretti Federica , Martignone Francesca , Rodríguez-Muñiz Luis J.
Published: February 2022

Our research focuses on Mathematics Teacher Educator specialized knowledge. By means theoretical tools driven from Mathematics Teacher Specialized Knowledge model (MTSK model) we focus on teacher educators’ specialized knowledge and carry out a qualitative study in order to identify specific dimensions and domains of mathematics teacher educators’ specialized knowledge. We explore an extension of the MTSK model that can characterize the teacher educator’s specialized knowledge (Mathematics Teacher Educator Specialized Knowledge model) - MTESK model. Specifically, our focus will be on the Pedagogical Content Knowledge of the MTESK model.
Educación, IFE y TIC para el siglo XXI: Inglés Aplicado al Trabajo Social
Authors: García-Sánchez Soraya
Published: February 2022

Este libro combina la docencia, el aprendizaje y la innovación con la investigación de Inglés para Fines Específicos (IFE), centrándose en la competencia lingüística, comunicativa y multimodal en lengua inglesa. Identifica retos, motivaciones y perfiles del alumnado universitario del siglo XXI, así como distintos enfoques de enseñanza-aprendizaje para IFE en modalidad presencial y no presencial, tomando como muestra el contexto de Inglés Aplicado al Trabajo Social, que puede adaptarse a otros entornos IFE en Educación Superior.
Göller Yöresinde Farklı Lokasyonlarda Doğal Olarak Yetişen Smyrnium connatum Boiss. & Kotschy’nin Uçucu Yağ Bileşenlerinin Karakterizasyonu
Authors: Tosun Bekir , Şanlı Arif , Karadoğan Tahsin , Cirit Yeşim , Ok Fatma Zehra
Published: February 2022

Araştırma Göller Yöresi (Türkiye) florasında farklı lokasyonlarda doğal olarak yetişen Smyrnium connatum Boiss & Kotschy meyve uçucu yağ oranı ve bileşenlerinin belirlenmesi amacıyla 2016 yılında yürütülmüştür. Meyve örneklerinin uçucu yağ oranları Clavenger tipi hidro-distilasyon cihazında, uçucu yağ bileşenleri ise GC/MS’de belirlenmiştir. Farklı lokasyonlardan alınan meyve örneklerinin uçucu yağ oranları % 1.75 ile % 5.00 arasında geniş bir varyasyon göstermiştir. Çalışmada uçucu yağı oluşturan bileşenler ve oranları bakımından da önemli farklılıklar tespit edilmiş, bileşen sayısının lokasyonlara göre 43 ile 72 arasında değiştiği ve türe ait meyvelerde toplam 85 farklı bileşen bulunduğu belirlenmiştir. Tüm lokasyonlardan elde edilen uçucu yağlarda da yüksek oranlarda bulunan curzerene (% 15.56-25.45), β- elemene (% 4.83-10.63), germacrene B (% 4.32-9.14), germacrene D (% 7.78-11.77), procerin (% 5.23-6.69) ve furanodiene (% 3.98-12.97)’in önemli bileşenler olduğu ve uçucu yağların yüksek oranda seskiterpenlerden oluştuğu (% 72.80-92.07) belirlenmiştir. Çalışmada, S. connatum meyve uçucu yağının türün yetiştiği bölgenin ekolojik koşullarına bağlı olarak önemli derecede kalitatif ve kantitatif farklılıklar gösterdiği ve gerek kültüre alma gerekse farklı alanlarda kullanılmalarında bu faktörlerin göz önünde bulundurulması gerektiği sonucuna varılmıştır.
Una aproximación al panorama actual de las nuevas formas de consumo de drogas
Authors: Isorna Folgar Manuel , Arias Horcajadas Francisco
Published: February 2022

El consumo de drogas está muy arraigado en la “cultura” occidental y su consumo se relaciona con tradiciones, celebraciones o espacio de ocio. Sin embargo, estos consumos no están exentos de riesgos que dependen de la cantidad, frecuencia y patrón de consumo, así como de las características de la persona consumidora como edad, sexo y algunas condiciones de salud. Mientras la evidencia científica acumula pruebas de la toxicidad de las drogas, sigue existiendo una creciente oferta y demanda de las mismas debido principalmente a la aparición o el redescubrimiento de nuevas sustancias psicoactivas y “el atractivo” de las nuevas formas o patrones de consumo. Paradójicamente, pese a la creciente preocupación que suscitan estos nuevos patrones de consumo son muy pocos los trabajos realizados en nuestro país que analizan esta temática.
The Impact of COVID-19 That Outbreak on the Quality Education vs. Role of Social Worker in the Context of Nepal
Authors: Tamang Rajesh , Nepali Som
Published: February 2022

Abstract The article discusses about the current situation of Novel Corona Virus also called as the COVID-19 that hinder for all human’s life including the education. Rapidly escalating COVID-19, has caused havoc in quality education and every educational institution are closed. As the UNESCO report it showed that 1.6 billion children being affected due to the close of institution across 191 countries. With the alternative method every education institution started blended learning virtual classes in order to continue learning environment in students. The articles investigate COVID-19 impact on student’s quality education in Nepal and social work implication. The findings of the study shows that the COVID-19 has seriously effects on the students learning environment. It showed the huge gap between getting the good education in Nepal. However, Nepal has also made some policies to provide equal quality education to all the children through the ICT and also encourage social work to actively participate on providing education to all the majority of group children in Nepal. Whereas social work applied the micro, messo, and macro level of implication in practice to provide the education for children in remote area of Nepal.
Effects of Data Quality and Quantity on Deep Learning for Protein-Ligand Binding Affinity Prediction
Authors: Fan Frankie J , Shi Yun
Published: February 2022

Prediction of protein-ligand binding affinities is crucial for computational drug discovery. A number of deep learning approaches have been developed in recent years to improve the accuracy of such affinity prediction. While the predicting power of these systems have advanced to some degrees depending on the dataset used for model training and testing, the effects of the quality and quantity of the underlying data have not been thoroughly examined. In this study, we employed erroneous datasets and data subsets of different sizes, created from one of the largest databases of experimental binding affinities, to train and evaluate a deep learning system based on convolutional neural networks. Our results show that data quality and quantity do have significant impacts on the performance of trained models. Depending on the variations in data quality and quantity, the performance discrepancies could be comparable to or even larger than those observed among dif-ferent deep learning approaches. This implies that continued accumulation of high-quality affinity data, especially for proteins without any affinity data, is important for improving deep learning models to better predict protein-ligand binding affinities.
Positive Mental Health in University Students and Its Relations with Psychological Vulnerability, Mental Health Literacy and Sociodemographic Characteristics: A Descriptive-Correlational Study
Authors: Teixeira Sónia , Ferré-Grau Carme , Sequeira Carlos Alberto , Pires Regina , Carvalho José Carlos , Ribeiro Isilda , Sequeira Carolina , Rodrigues Teresa , Sampaio Francisco , Costa Tiago , Lluch i Canut Maria Teresa
Published: February 2022

Resumo: Este estudo teve como objetivo avaliar a Saúde Mental Positiva (SPM) e a sua relação com características sociodemográficas, literacia em saúde mental e escala de vulnerabilidade psicológica (PVS) em estudantes universitários portugueses com idades compreendidas entre os 17 e os 62 anos. Foi realizado um estudo descritivo-correlacional. Uma pesquisa online foi realizada para avaliar variáveis ​​demográficas, e vários questionários foram aplicados para avaliar saúde mental positiva, vulnerabilidade psicológica e alfabetização em saúde mental. Os dados foram coletados de 1º de novembro de 2019 a 1º de setembro de 2020. No geral, 3.405 alunos participaram do estudo. Os resultados mostram que 67,8% dos alunos revelaram um alto nível de PMH, 31,6% apresentaram um nível médio de PMH e 0,6% apresentaram um nível baixo de PMH. Os estudantes do sexo masculino relataram maior satisfação pessoal (t (3170) = -2,39, p=0,017) e autonomia (t (3170) = -3,33, p=0,001), no PMH em relação ao sexo feminino. Alunos sem bolsa pontuaram mais alto (t (3.127) = -2,04, p=0,42) no PMH do que alunos com bolsa. Estudantes que não foram deslocados de casa relataram maior (t (3170) = -1,99, p=0,047) Autocontrole em PMH do que aqueles deslocados de sua casa. Estudantes universitários com resultados de PMH mais altos têm resultados de PVS mais baixos e resultados de Alfabetização mais altos. Os achados deste estudo contribuirão para identificar as necessidades de intervenção dos alunos na PMH. Estudantes universitários com resultados de PMH mais altos têm resultados de PVS mais baixos e resultados de Alfabetização mais altos. Os achados deste estudo contribuirão para identificar as necessidades de intervenção dos alunos na PMH. Estudantes universitários com resultados de PMH mais altos têm resultados de PVS mais baixos e resultados de Alfabetização mais altos. Os achados deste estudo contribuirão para identificar as necessidades de intervenção dos alunos na PMH.
The Role of Quasi-Stationary Waves in Annual Cycle in Mid-Latitude Stratospheric and Mesospheric Ozone in 2011-2020
Authors: Zhang Chenning , Evtushevsky Oleksandr , Milinevsky Gennadi , Andrienko Yulia , Shulga Valerii , Han Wei , Shi Yu
Published: February 2022

The purpose of this work is to study quasi-stationary wave structure in the mid-latitude stratosphere and mesosphere (40–50°N) and its role in the formation of the annual ozone cycle. Geopotential height and ozone from Aura MLS data are used and winter climatology for January–February 2011–2020 is considered. More closely examined is the 10-degree longitude segment centered on Longfengshan Brewer station, China, and located in the region of the Aleutian Low influence associated with the quasi-stationary zonal maximum of total ozone. Annual and semi-annual oscillations in ozone were compared using units of ozone volume mixing ratio and concentration, as well as changes in ozone peak altitude and in time series of ozone at individual pressure levels between 316 hPa (9 km) and 0.001 hPa (96 km). The ozone maximum in the vertical profile is higher in volume mixing ratio (VMR) values than in concentration by about 15 km (5 km) in the stratosphere (mesosphere), in consistency with some previous studies. We found that the properties of the annual cycle are better resolved in the altitude range of the main ozone maximum: middle–upper stratosphere in VMR and lower stratosphere in concentration. Both approaches reveal SAO/AO-related changes in the of ozone peak altitudes in a range of 4–6 km during the year. In the lower-stratospheric ozone of the Longfengshan domain, an earlier development of the annual cycle takes place with a maximum in February and a minimum in August compared to spring and autumn, respectively, in zonal means. This is presumably due to the higher rate of dynamical ozone accumulation in the region of the quasi-stationary zonal ozone maximum. The “no-annual-cycle” transition layers are found in the stratosphere and mesosphere. These layers with undisturbed ozone volume mixing ratio throughout the year are of interest for more detailed future study.
Foreign Doctorate Students in Europe
Authors: Laureti Lucio , Costantiello Alberto , Matarrese Marco Maria , Leogrande Angelo
Published: February 2022

The determinants of the presence of “Foreign Doctorate Students” among 36 European Countries for the period 2010-2019 are analyzed in this article. Panel Data with Fixed Effects, Random Effects, WLS, Pooled OLS, and Dynamic Panel are used to investigate the data. We found that the presence of Foreign Doctorate Students is positively associated to “Attractive Research Systems”, “Finance and Support”, “Rule of Law”, “Sales Impacts”, “New Doctorate Graduates”, “Basic School Entrepreneurial Education and Training”, “Tertiary Education” and negatively associated to “Innovative Sales Share”, “Innovation Friendly Environment”, “Linkages”, “Trademark Applications”, “Government Procurement of Advanced Technology Products”, “R&D Expenditure Public Sectors”. A cluster analysis was then carried out through the application of the unsupervised k-Means algorithm optimized using the Silhouette coefficient with the identification of 5 clusters. Finally, eight different machine learning algorithms were used to predict the value of the "Foreign Doctorate Students" variable. The results show that the best predictor algorithm is the "Tree Ensemble Regression" with a predicted value growing at a rate of 114.03%.
Provider-Patient Interactions as Predictors of Lifestyle Behaviors Related to the Prevention and Management of Diabetes
Authors: Robles Brenda , Kuo Tony
Published: February 2022

Growing evidence suggests that healthcare provider advice may increase tobacco cessation, reduce alcohol use, and improve the adoption of desirable lifestyle behaviors among patients. However, how brief interventions and other provider-patient interactions can shape cumulative adoption of multiple modifiable behaviors is less well studied for diabetes prevention and control. Using weighted internet panel survey data from a large socio-demographically diverse urban population in the United States (n=1,003), the present study describes differences in group characteristics among those who had been “ever diagnosed” with prediabetes/diabetes versus those who had not. It also examines the associations between the cumulative adoption of lifestyle behaviors and each of the following: a) lifetime prediabetes/diabetes diagnosis; b) brief lifestyle intervention exposure (i.e., received provider advice/encouragement); and c) recent provider-patient communication about diabetes. There were several group differences in “ever diagnosed” prediabetes/diabetes status by age, employment status, health status, nutrition knowledge, blood pressure/hypertension diagnosis, and diabetes-related health behaviors (p<0.05). Each of the three provider-patient interactions of interest were positively associated with a higher cumulative sum of adopted modifiable lifestyle behaviors for diabetes prevention and management. Results suggest that provider advice/provider-patient interactions of any type can have a salutary impact on whether individuals with prediabetes or type 2 diabetes will engage in recommended lifestyle behavior modifications.
Two-layer completely conservative gas dynamics schemes with nodal approximation and adaptive regularization of the solution in Euler variables
Authors: Rahimly Orkhan Rahim oglu , Poveschenko Yuri Andreevich , Popov Sergey Borisovich , Podryga Victoria Olegovna , Rahimly Parvin Ilgar gizi
Published: February 2022

The paper investigates the stability of a family of two-layer in time completely conservative difference schemes with space-profiled time weights for the system of equations of gas dynamics in Euler variables using adaptive artificial viscosity. Regularization of divergent flows of mass, momentum and internal energy of the equations of gas dynamics using adaptive artificial viscosity that does not violate the properties of complete conservatism of schemes of this class is proposed. Regularized flows make the scheme quasi-monotonic. The results are numerically tested based on Einfeldt problems and shock wave calculations.
Prediction of the Continuous Probability of Sand Screenout Based on a Deep Learning Workflow
Authors: Hou Lei , Cheng Yiyan , Elsworth Derek , Liu Honglei , Ren Jianhua
Published: February 2022

Sand screenout is one of the most serious and frequent challenges that threaten the efficiency and safety of hydraulic fracturing. Current low prices of oil/gas drive operators to control costs by using lower viscosity and lesser volumes of fluid for proppant injection—thus reducing the sand-carrying capacity in the treatment and increasing the risk of screenout. Current analyses predict screenout as isolated incidents based on the interpretation of pressure or proppant accumulation. We propose a method for continuous evaluation and prediction of screenout by combining data-driven methods with field measurements recovered during shale gas fracturing. The screenout probability is updated, redefined, and used to label the original data. Three determining elements of screenout are proposed, based on which four indicators are generated for training a deep learning model [gated recurrent units (GRU), tuned by the grid search and walk-forward validation]. Training field records following screenout are manually trimmed to force the machine learning algorithm to focus on the prescreenout data, which then improves the prediction of the continuous probability of screenout. The Pearson coefficients are analyzed in the STATA software to remove obfuscating parameters from the model inputs. The extracted indicators are optimized, via a forward selection strategy, by their contributions to the prediction according to the confusion matrix and root mean squared error (RMSE). By optimizing the inputs, the probability of screenout is accurately predicted in the testing cases, as well as the precursory predictors, recovered from the probability evolution prior to screenout. The effect of pump rate on screenout probability is analyzed, defining a U-shaped correlation and suggesting a safest-fracturing pump rate (SFPR) under both low- and high-stress conditions. The probability of screenout and the SFPR, together, allow continuous monitoring in real time during fracturing operations and the provision of appropriate screenout mitigation strategies.
Fully 3D Simulation of Hydraulic Fracture Propagation in Naturally Fractured Reservoirs Using Displacement Discontinuity Method
Authors: Tang Huiying , Liang Haipeng , Zhang Liehui , Li Hangyu
Published: February 2022

The shape, size, and orientation of natural fractures significantly impact the geometry of hydraulic fractures in unconventional reservoirs, such as shale gas/oil, tight gas, and enhanced geothermal system. The behaviors after the hydraulic fracture encounters natural fractures have been summarized as crossing, diverting, step over, and stopping based on a great number of numerical and experimental analysis with plain strain assumptions. However, under practical situations, the geometries of natural and hydraulic fractures are much more complex than the vertical and rectangular shape assumed by 2D models. The experimental studies on the role of height and inclination of natural fractures have revealed some other phenomena (e.g., bypassing process that the fluid-driven hydraulic fracture propagates up the back side of the natural fracture), which are unable to be captured in 2D. To better describe the intersection behaviors among different kind of fractures, a fully 3D model based on the displacement discontinuity method (DDM) is developed on top of our previous models, which only considered the propagation of hydraulic fractures. A novel crossing criterion to judge whether the hydraulic fracture will cross the cemented natural fracture in 3D is proposed. The successive node snapping scheme is adopted to construct conforming meshes for the evolving intersected curves between hydraulic and natural fracture surfaces, which only alters the location of a small fraction of nodes without changing the nodal connectivity. With this model, the evolution of fracture geometry after the hydraulic fracture intersects with the natural fractures of different toughness, size, orientation, and number is investigated. Because an extra dimension is considered, the fractures are allowed to propagate in more directions, resulting in a series of complex fracture geometries. The dynamic grid evolution method proposed in this work can promote the development of DDM in modeling fully 3D fracture networks in naturally fractured reservoirs.
Fourier Neural Operator for Solving Subsurface Oil/Water Two-Phase Flow Partial Differential Equation
Authors: Zhang Kai , Zuo Yuande , Zhao Hanjun , Ma Xiaopeng , Gu Jianwei , Wang Jian , Yang Yongfei , Yao Chuanjin , Yao Jun
Published: February 2022

While deep learning has achieved great success in solving partial differential equations (PDEs) that accurately describe engineering systems, it remains a big challenge to obtain efficient and accurate solutions for complex problems instead of traditional numerical simulation. In the field of reservoir engineering, the current mainstream machine learning methods have been successfully applied. However, these popular methods cannot directly solve the problem of 2D two-phase oil/water PDEs well, which is the core of reservoir numerical simulation. Fourier neural operator (FNO) is a recently proposed high-efficiency PDE solution architecture that overcomes the shortcomings of the above popular methods, which can handle this type of PDE problem well in our work. In this paper, a deep-learning-based model is developed to solve three categories of problems controlled by the subsurface 2D oil/water two-phase flow PDE based on the FNO. For this complex engineering equation, we consider many factors, select characteristic variables, increase the dimension channel, expand the network structure, and realize the solution of the engineering problem. The first category is to predict the distribution of saturation and pressure fields by PDE parameters. The second category is the prediction of time series. The third category is for the inverse problem. It has achieved good results on both forward and inverse problems. The network uses fast Fourier transform (FFT) to extract PDE information in Fourier space to approximate differential operators, making the network faster and with greater physics significance. The model is mesh-independent and has good generalization, which also shows superresolution. Compared to the original FNO, we improve the network structure, add physical constraints to deal with boundary conditions (BCs), and use a shape matrix to control irregular boundaries. Also, we have improved the FFT module to make the transformation smoother. Compared with advanced deep learning-based solvers at different resolutions, the results show that this model overcomes some shortcomings of popular algorithms such as physics-informed neural networks (PINNs) and fully convolutional network (FCN) and has stronger accuracy and applicability. Our work has great potential in the replacement of traditional numerical methods with neural networks for reservoir numerical simulation.
TIM-1 promotes proliferation and metastasis, and inhibits apoptosis, in cervical cancer through the PI3K/AKT/p53 pathway
Authors: Chen Liuyan , Qing Jilin , Xiao Yangyang , Huang Xiaomei , Chi Yanlin , Chen Zhizhong
Published: February 2022

Background
T-cell immunoglobulin mucin-1 (TIM-1) has been reported to be associated with the biological behavior of several malignant tumors; however, it is not clear whether it has a role in cervical cancer (CC).
Methods
TIM-1 expression in cervical epithelial tumor tissues and cells was detected by immunohistochemistry or real-time quantitative-PCR and western blotting. CC cells from cell lines expressing low levels of TIM-1 were infected with lentiviral vectors encoding TIM-1. Changes in the malignant behavior of CC cells were assessed by CCK-8, wound healing, Transwell migration and invasion assays, and flow cytometry in vitro; while a xenograft tumor model was established to analyze the effects of TIM-1 on tumor growth in vivo. Changes in the levels of proteins related to the cell cycle, apoptosis, and Epithelial-mesenchymal transition (EMT) were determined by western blotting.
Results
TIM-1 expression was higher in CC tissues, than in high grade squamous intraepithelial lesion, low grade squamous intraepithelial lesion, or normal cervical tissues, and was also expressed in three CC cell lines. In HeLa and SiHa cells overexpressing TIM-1, proliferation, invasion, and migration increased, while whereas apoptosis was inhibited. Furthermore, TIM-1 downregulated the expression of p53, BAX, and E-cadherin, and increased cyclin D1, Bcl-2, Snail1, N-cadherin, vimentin, MMP-2, and VEGF. PI3K, p-AKT, and mTOR protein levels also increased, while total AKT protein levels remained unchanged.
Conclusions
Our study indicated that TIM-1 overexpression promoted cell migration and invasion, and inhibited cell apoptosis in CC through modulation of the PI3K/AKT/p53 and PI3K/AKT/mTOR signaling pathways, and may be a candidate diagnostic biomarker of this disease.
Incidence of falls and fall-related injuries and their predictive factors in frail older persons with cancer: a multicenter study
Authors: Kenis Cindy , Decoster Lore , Flamaing Johan , Debruyne Philip R , De Groof Inge , Focan Christian , Cornélis Frank , Verschaeve Vincent , Bachmann Christian , Bron Dominique , Bulck Heidi Van den , Schrijvers Dirk , Langenaeken Christine , Specenier Pol , Jerusalem Guy , Praet Jean-Philippe , De Cock Jessie , Lobelle Jean-Pierre , Wildiers Hans , Milisen Koen
Published: February 2022

Background: Falls and fall-related injuries are a major public health problem. Data on falls in older persons with cancer is limited and robust data on falls within those with a frailty profile are missing. The aim of this study is to investigate the incidence and predictive factors for falls and fall-related injuries in frail older persons with cancer. Methods: This study is a secondary data analysis from data previously collected in a large prospective multicenter observational cohort study in older persons with cancer in 22 Belgian hospitals (November 2012-February 2015). Patients ≥70 years with a malignant tumor and a frailty profile based on an abnormal G8 score were included upon treatment decision and evaluated with a Geriatric Assessment (GA). At follow-up, data on falls and fall-related injuries were documented. Results: At baseline 2141 (37.2%) of 5759 included patients reported at least one fall in the past 12 months, 1427 patients (66.7%) sustained an injury. Fall-related data of 3681 patients were available at follow-up and at least one fall was reported by 769 patients (20.9%) at follow-up, of whom 289 (37.6%) fell more than once and a fall-related injury was reported by 484 patients (62.9%). Fear of falling was reported in 47.4% of the patients at baseline and in 55.6% of the patients at follow-up. In multivariable analysis, gender and falls history in the past 12 months were predictive factors for both falls and fall-related injuries at follow-up. Other predictive factors for falls, were risk for depression, cognitive decline, dependency in activities of daily living, fear of falling, and use of professional home care. Conclusion: Given the high number of falls and fall-related injuries and high prevalence of fear of falling, multifactorial falls risk assessment and management programs should be integrated in the care of frail older persons with cancer. Trial registration: B322201215495
Using Dual Polarities of Transcranial Direct Current Stimulation in Global Cerebral Ischemia and its following reperfusion period Attenuates Neuronal Injury
Authors: Kaviannejad Rasoul , Karimian Seyed Morteza , Riahi Esmail , Ashabi Ghorbangol
Published: February 2022

Multiple neuronal injury pathways are activated during cerebral ischemia and reperfusion (I/R). This study was designed to decrease potential neural injuries by using both transcranial direct current stimulation (tDCS) polarities in cerebral ischemia and its following reperfusion periods. Ninety rats were randomly divided into six groups. In the sham group, rats were intact. In the I/R group, global cerebral I/R was only induced. In the I/R+c-tDCS and I/R+a-tDCS groups, cathodal and anodal currents were applied, respectively. In the I/R+c/a-tDCS, cathodal current was used in the ischemia and anodal in the reperfusion. In the I/R+a/c-tDCS group, cathodal and anodal currents were applied in the I/R, respectively. H ippocampal tissue was used to determine the levels of IL-1β, TNF-α, NOS, SOD, MDA, and NMDAR. Hot plate and open field tests evaluated sensory and locomotor performances. The cerebral edema was also measured. Histological assessment was assessed by H/E and Nissl staining of the hippocampal CA1 region. All tDCS modes significantly decreased IL-1β and TNF-α levels, especially in the c/a-tDCS. All tDCS caused a significant decrease in MDA and NOS levels while increasing SOD activity compared to the I/R group, especially in the c/a-tDCS mode. In the c-tDCS and a/c-tDCS groups, the NMDAR level was significantly decreased. The c/a-tDCS group improved sensory and locomotor performances more than other groups receiving tDCS. Furthermore, the least neuronal death was observed in the c/a-tDCS mode. Using two different polarities of tDCS could induce more neuroprotective versus pathophysiological pathways in cerebral I/R, especially in c/a-tDCS mode.
Efb released by intracellular Staphylococcus aureus suppresses host immunity by targeting TRAF3
Authors: Zhang Xiaokai , Xiong Tingrong , Gao Lin , Wang Yu , Liu Luxuan , Tian Tian , Shi Yun , Jinyong Zhang , Zhao Zhuo , Lu Dongshui , Luo Ping , Cheng Ping , Zhang Weijun , Jing Haiming , Gou Qiang , Zeng Hao , Yan Dapeng , Zou Quanming
Published: February 2022

Many pathogens secrete effectors to hijack intracellular signaling regulators in host immune cells to promote pathogenesis. However, the pathogenesis of Staphylococcus aureus (S. aureus) secretory effectors within host cells is unclear. Here, we report that intracellular S. aureus secretes fibrinogen binding protein (Efb) into the cytoplasm of macrophages to inhibit proinflammatory cytokine expression and suppress host immunity. Mechanistically, RING finger protein 114, a host E3 ligase, mediates K27-linked ubiquitination of Efb at lysine 71, which facilitates the recruitment of TNF receptor associated factor 3 (TRAF3). The binding of Efb to TRAF3 disrupts the formation of the TRAF3/TRAF2/cIAP1 complex, which mediates K48-ubiquitination of TRAF3 to promote degradation, resulting in suppression of the inflammatory signaling cascade. Additionally, the Efb K71R mutant loses the ability to inhibit inflammation and exhibits decreased pathogenicity. Therefore, our findings identify an unrecognized mechanism of S. aureus to suppress host defense, which may be a promising target for developing effective anti-S. aureus immunomodulators.
Lean, Agile, Resilient, And Green Human Resource Management: The Impact On Organizational Innovation And Organizational Performance
Authors: Alipour Nima , Nazari-Shirkouhi Salman , Sangari Mohamad Sadegh , Vandchali Hadi Rezaei
Published: February 2022

There are four paradigms of lean, agile, resilient, and green (LARG) which can promote human resource culture to create novel ideas and increase performance in organizations. This study aims to conceptualize lean, agile, resilient, and green paradigms in human resource management (HRM) and investigates how different LARG HRM elements can affect organizational innovation and performance. In this way, a conceptual model for investigating the LARG concept in HRM is proposed. A new tool to measure lean, agile, resilient, and green indicators in service industry has been developed. Using convenience sampling method to access possible respondents, a survey questionnaire is managed to collect data from 102 service sector organizations in Iran. The collected data are analyzed by partial least squares-structural equation modeling (PLS-SEM). The results indicate that the LARG HRM significantly and positively influences organizational performance. In addition, the LARG HRM indirectly affects organizational performance through organizational innovation. This study provides valuable insights into implementing the LARG HRM in organizations and how it contributes to enhancing organizational performance.
Health Outcomes, Health Services Utilization, and Costs Consequences of Medicare Uninsurance among Migrants in Canada: A Systematic Review
Authors: Garasia Sophiya , Bishop Valerie , Clayton Stephanie , Pinnington Genevieve , Arinze Chika , Jalil Ezza
Published: February 2022

Background: Medically uninsured groups, many of them migrants, reportedly delay using healthcare services due to costs and often face preventable health consequences. This systematic review sought to assess quantitative evidence on health outcomes, health care utilization, and health care costs among uninsured migrant populations in Canada.Methods: OVID MEDLINE, Embase, Global Health, EconLit, and grey literature were searched to identify relevant literature published up until March 2021. The Cochrane Risk of Bias in Non-randomized Studies – of Interventions (ROBINS-I) tool was used to assess the quality of studies.Results: 10 studies were included. Data showed there are differences among insured and uninsured groups in reported health outcomes and healthcare use. No quantitative studies on economic costs were captured. Conclusions: Our findings indicate a need to review policies regarding accessible and affordable health care for migrants. Increasing funding to community health centers may improve service utilization and health outcomes among this population.
Proteomic signature of tubulointerstitial tissue predicts prognosis in IgAN
Authors: Paunas Flavia Teodora Ioana , Finne Kenneth , Leh Sabine , Marti Hans-Peter , Berven Frode , Vikse Bjørn Egil
Published: February 2022

Background: IgA nephropathy (IgAN) is associated with a significant risk of progression to kidney failure. Tubular atrophy is an established important risk factor for progressive disease, but few studies have investigated tubulointerstitial molecular markers and mechanisms of progression in IgAN. Methods: Based on data from the Norwegian Renal Registry, two groups were included: IgAN patients with (n=9) or without (n=18) progression to kidney failure during 10 years of follow-up. Tubulointerstitial tissue without discernible interstitial expansion or pronounced tubular alterations was microdissected, proteome was analysed using tandem mass spectrometry and relative protein abundances were compared between groups. Results: Proteome analyses quantified 2562 proteins with at least 2 unique peptides. Of these, 150 proteins had significantly different abundance between progressive and non-progressive IgAN patients, 67 were more abundant and 83 less abundant. Periostin was the protein with the highest fold change between progressive and non-progressive IgAN (fold change 8.75, p<0.05) and periostin staining was also stronger in patients with progressive vs non-progressive IgAN. Reactome pathway analyses showed that proteins related to inflammation were more abundant and proteins involved in mitochondrial translation were significantly less abundant in progressive vs non-progressive patients.Conclusions: Microdissection of tubulointerstitial tissue with only mild damage allowed for identification of proteome markers of early progressive IgAN. Periostin abundance showed promise as a novel and important risk marker of progression.