bluuebunny/crossref_metadata_2025 huggingface dataset:
O que cortar com a navalha: economia na Gramática Gerativa e na Sintaxe mais Simples
Authors: Miliorini Rafaela
Published: August 2018

Este estudo propõe uma discussão teórica que compara alguns estágios da Gramática Gerativa Tradicional (CHOMSKY, 1965, 1981, 1995) à proposta da Sintaxe mais Simples (CULICOVER; JACKENDOFF, 2005) no que diz respeito às noções de economia e parcimônia para a construção e o desenvolvimento de uma teoria naturalista da linguagem. A GGT, tradicionalmente, objetiva a simplificação das regras de formação – minimizando os princípios que compõem a gramática – o que leva à postulação de estruturas sintáticas mais detalhadas. A Sintaxe mais Simples aplica a Navalha de Ockham na própria estrutura sintática; consequentemente, a teoria precisa refinar as regras de formação e projetar a sintaxe em uma estrutura flat. Isso se torna possível por meio de uma arquitetura em paralelo, em que fonologia, sintaxe e semântica dividem a complexidade estrutural, assegurando uma maior autonomia da sintaxe.
Aspectos epidemiológicos e adesão ao tratamento de tuberculose segundo coinfecção do HIV em pacientes do programa de controle da tuberculose de município prioritário do estado de São Paulo
Authors: Setolim Marivalda de Almeida , Andreoni Solange , Vieira Amadeu Antônio
Published: August 2018

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Concepções de envelhecimento e velhice na voz de universitários
Authors: Leite Marinês Tambara , Hildebrandt Leila Mariza , Massariol Ana Maria , Machado Bruna Bender Companhoni
Published: August 2018

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Influence of academic training on the understanding of the health-disease process and on the value assigned to the teeth
Authors: Fadel Cristina Berger , Pacheco Karina Tonini dos Santos , Carvalho Raquel Baroni de , Bordin Danielle , Ribeiro Mariana Dias Flor
Published: August 2018

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Fatores alimentares e nutricionais associados ao hábito de assistir à televisão entre crianças de uma escola particular de Bento Gonçalves/RS
Authors: Mas Mariana Dal , Bernardi Juliana Rombaldi , Possa Gabriela
Published: August 2018

Eating and nutritional factors associated with the habit of watching TV among private school children
O conhecimento dos médicos sobre a atuação fonoaudiológica pré e pós-operatória de gastroplastia em um município do Rio Grande do Sul
Authors: Machado Camila Couto , Cesa Carla Ciceri , Santos Andréa Cavalcante dos
Published: August 2018

Knowledge and awareness among physicians of the role of phonoaudiology in pre and post-operative gastroplasty in a city of Rio Grande do Sul
Saúde mental e justiça: os desafos do cuidado em rede
Authors: Pedrosa Tacianna Bandim , Moreira Maria Inês Badaró
Published: August 2018

Mental health and justice: network care challenges
Formação em saúde e extensão universitária: discutindo sexualidade e prevenção de IST/aids
Authors: Guimarães Denise Alves , Oliveira Cândida Amélia Marinho de , Lima Rânia Andrade , Silva Leandro César da , Avelar Camila Reis Teixeira , Gama Carlos Alberto Pegolo da
Published: August 2018

Education in health and university extension: discussing sexuality and STD/HIV prevention
Effects of Human Full-length Amelogenin and C-terminal Amelogenin Peptide on the Proliferation of Human Mesenchymal Stem Cells Derived from Adipose Tissue
Authors: Ando Kazuyo , Kunimatsu Ryo , Awada Tetsuya , Yoshimi Yuki , Tsuka Yuji , Sumi Keisuke , Horie Kayo , Abe Takaharu , Nakajima Kengo , Tanimoto Kotaro
Published: August 2018

Amelogenins are enamel matrix proteins that play crucial roles in enamel formation. Previous studies
have indicated that amelogenin and amelogenin C-terminal peptides have cell-signaling functions. Recently,
adipocyte-derived mesenchymal stem cells (ADSCs) have received attention as a potential source of stem cells
for use in regeneration therapy. In this study, we examined the effects of human full-length amelogenin (rh174)
and amelogenin C-terminal peptide (amgCP) on the proliferation of ADSCs. ADSCs were cultured in the presence
of amgCP or rh174. Cell proliferation was analyzed using BrdU immunoassay and MTS assay. Cell migration
was evaluated by ELISA. The MAPK-ERK pathway was examined by phospho-p44/42 MAPK
(Thr202/Tyr204) sandwich ELISA and western blotting. A specific MAPK inhibitor, U0126, was used to block
ERK activity. ADSC proliferation and migration were significantly (P < 0.05) increased in the presence of rh174
or amgCP compared to non-treated control cells. The increased proliferation of ADSCs induced by rh174 or
amgCP was significantly (P < 0.05) inhibited in the presence of 2 µg/ml U0126. The pERK/tERK ratio was significantly
(P < 0.05) increased upon treatment with rh174 or amgCP compared to non-treated ADSCs, while this
increase was significantly (P < 0.05) suppressed by the addition of U0126. Similar results were found by western
blot analysis. In conclusion, amgCP and rh174 increase ADSC proliferation via the MAPK-ERK signaling pathway,
and ADSCs may be useful for tissue regeneration in the orofacial region.
Thioredoxin as a Therapeutic Target in Cerebral Ischemia
Authors: Zeng Xian-Si , Geng Wen-Shuo , Chen Lei , Jia Jin-Jing
Published: August 2018

Background:

Cerebral ischemia is a common cause of disability and death. Ischemic brain injury results
from complex pathological processes, including oxidative stress, inflammation, and apoptosis. Thioredoxin(
Trx) is an important multifunctional protein, which regulates cellular redox status. Increasing studies have
demonstrated that Trx provides a neuroprotective role against cerebral ischemia-induced injury.

Methods:

A systematic search of PMC and the PubMed Database was conducted to summarize the protective
effects of Trx against cerebral ischemia.

Results:

This article reviews the understanding of potential effects and mechanisms of Trx against cerebral
ischemia, including the anti-oxidant, anti-apoptotic and anti-inflammatory effects, as well as the activation of prosurvival
pathway. We also summarize that some natural compounds induce the expression of Trx, which is involved
in their anti-ischemic effects.

Conclusion:

In conclusion, Trx has a potential neuroprotection in cerebral ischemia and may be very promising
for clinical therapy of ischemic stroke in the future.
Emerging and Alternative Therapies For Parkinson Disease: An Updated Review
Authors: Kabra Atul , Sharma Rohit , Kabra Ruchika , Baghel Uttam Singh
Published: August 2018

Parkinson's disease (PD) is standout amongst the most common neurodegenerative malady with
unpredictable dynamic pathology. At present, accessible traditional choices for PD have certain impediments of
their own, and subsequently persistent consistence and fulfillment are low. Current contemporary treatment options
just give symptomatic alleviation constrained control to anticipate malady progression, bringing about poor
patient consistence and fulfilment. Numerous rising pharmacotherapies for PD are in various phases of medical
improvement. Treatments incorporate adenosine A2A receptor antagonists, anti-apoptotic agents, monoamine
oxidase inhibitors, glutamate receptor antagonists, and antioxidants for example, N-acetyl cysteine, edaravone,
and coenzyme Q10. Other rising nonpharmacotherapies incorporate microRNAs, viral vector gene therapy, stem
cells transglutaminases, RTP801, and glial derived neurotrophic factor (GDNF). Furthermore, surgeries including
profound pallidotomy, deep brain stimulation, thalamotomy and gamma knife surgery have developed as elective
mediations for cutting edge PD patients who have totally used common medications and still suffer from unrelenting
motor symptoms. Complementary and Alternative medicine (CAM) modalities, such as Yoga, acupuncture,
Tai Chi, Music therapies are highly practiced in several countries, offer some of the safer and effective
treatment modalities for PD. While a few of these treatments hold much assurance in postponing the beginning of
ailment and moderating its progression, more pharmacotherapies and careful mediations should be examined in
various phases of PD. Therefore, the main objective of our review is to fill the gap between the researches and
provide updated and productive information about the research reported in the last couple of years and can fulfil
the most reassuring plausibility for encourage treatment of Parkinson Disease.
Chinese Herbal Medicine Hepatotoxicity: The Evaluation and Recognization Based on Large-scale Evidence Database
Authors: Liu Zhi , He Xin , Wang Lili , Zhang Yunhua , Hai Yue , Gao Rui
Published: August 2018

Background:

Due to the special nature of Chinese Herbal medicine and the complexity of its clinical use, it is difficult to identify and evaluate its toxicity and resulting herb induced liver injury (HILI).

Methods:

First, the database would provide full profile of HILI from the basic ingredients to clinical outcomes by the most advanced algorithms of artificial intelligence, and it is also possible that we can predict possibilities of HILI after patients taking Chinese herbs by individual patient evaluation and prediction. Second, the database would solve the chaos and lack of the relevant data faced by the current basic research and clinical practice of Chinese Herbal Medicine. Third, we can also screen the susceptible patients from the database and thus prevent the accidents of HILI from the very beginning.

Results:

The Roussel Uclaf Causality Assessment Method (RUCAM) is the most accepted method to evaluate DILI, but at present before using the RUCAM evaluation method, data resource collection and analysis are yet to be perfected. Based on existing research on drug-metabolizing enzymes mediating reactive metabolites (RMs), the aim of this study is to explore the possibilities and methods of building multidimensional hierarchical database composing of RMs evidence library, Chinese herbal evidence library, and individualized reports evidence library of herb induced liver injury HILI.

Conclusion:

The potential benefits lie in its ability to organize, use vast amounts of evidence and use big data mining techniques at the center for Chinese herbal medicine liver toxicity research, which is the most difficult key point of scientific research to be investigated in the next few years.
Preclinical Pharmacokinetics of Triptolide: A Potential Antitumor Drug
Authors: Song Wei , Liu Meilin , Wu Junjun , Zhai Hong , Chen Yong , Peng Zhihong
Published: August 2018

Background:

Triptolide, a bioactive component in Tripterygium wilfordii extracts, possess strong antiproliferative activity on all 60-National Cancer Institute (NCI) cancer cell lines. However, the widespread use of triptolide in the clinical practice is greatly limited for its multi-organ toxicity and narrow therapeutic window. All the toxic characteristics of triptolide are associated with the pharmacokinetics especially its distribution and accumulation in the target organ.

Methods:

The literature review was done using PubMed search, SciFinder and Google Scholar databases with specific keywords such as triptolide, pharmacokinetics, drug-drug interaction, transporters, metabolism, modification to collect the related full-length articles and abstracts from 2000 to 2018.

Results:

Oral triptolide is rapidly and highly absorbed. Grapefruit juice affects oral absorption, increasing the area under the concentration-time curve (AUC) by 153 % and the maximum concentration (Cmax) by 141 %. The AUC and the Cmax are not dose proportional. Triptolide distributes into the liver, heart, spleen, lung and kidney. Biotransformation of triptolide in rats includes hydroxylation, sulfate, glucuronide, N-acetylcysteine (NAC) and Glutathione (GSH) conjugation and combinations of these pathways. Less than 4 % of triptolide was recovered from the feces, bile and urine within 24 h. After repeating dosage, triptolide was eliminated quickly without accumulation in vivo. As a substrate of P-glycoprotein (P-gp) and CYP3A4, triptolide could have clinically significant pharmacokinetic interactions with those proteins substrates/inhibitors.

Conclusion:

The findings of this review confirm the importance of pharmacokinetic character for understanding the pharmacology and toxicology of triptolide.
Novel Therapeutic Potential of Mitogen-Activated Protein Kinase Activated Protein Kinase 2 (MK2) in Chronic Airway Inflammatory Disorders
Authors: Singh Rakesh Kumar , Najmi Abul Kalam
Published: August 2018

Objective:

The primary focus of this review is to highlight the current and emerging proinflammatory
role of MK2 kinase signaling in p38MAPK pathway and to provide a detailed evaluation
on the prospects of MK2 inhibition with special emphasis on the etiology of chronic inflammatory
airway diseases, such as asthma, idiopathic pulmonary fibrosis, lung cancer, acute lung injury and
acute respiratory distress syndrome.

Background:

MK2 belongs to serine-threonine kinase family and is activated directly by stress and
inflammatory signal through p38MAPK phosphorylation in diverse inflammatory conditions through
the Toll-like receptor signaling pathway. MK2 has been thought to be a critical factor involved in the
regulation of synthesis and release of pro-inflammatory (TNF-α, IL-6 and IL-1β, etc.) proteins. Targeted
inhibition of MK2 kinase has been shown to significantly reduce the production and release of
these cytokine molecules. Therefore, MK2 has been identified as an effective strategy (alternative to
p38MAPK) to block this pro-inflammatory signaling pathway.

Results:

The inhibition of MK2 may lead to similar or better efficacy as that of p38 inhibitors, and interestingly
avoids the systemic toxicity shown by the p38 inhibitors. Thus, MK2 has been the focus of
intense interdisciplinary research and its specific inhibition can be a novel and potential therapeutic
strategy for the treatment of chronic airway inflammatory diseases.

Conclusion:

Promising advancement in understanding and rigorous exploration of the role of MK2
kinase in inflammatory processes may contribute to the development of newer and safer therapy for
the treatment of chronic airway inflammatory diseases in the future.
Psychopharmacological Treatment of Obsessive-Compulsive Disorder (OCD)
Authors: Del Casale Antonio , Sorice Serena , Padovano Alessio , Simmaco Maurizio , Ferracuti Stefano , Lamis Dorian A. , Rapinesi Chiara , Sani Gabriele , Girardi Paolo , Kotzalidis Georgios D. , Pompili Maurizio
Published: August 2018

Background:

Obsessive-compulsive disorder (OCD) is associated with affective and cognitive symptoms causing personal distress and reduced global functioning. These have considerable societal costs due to healthcare service utilization.

Objective:

Our aim was to assess the efficacy of pharmacological interventions in OCD and clinical guidelines, providing a comprehensive overview of this field.

Methods:

We searched the PubMed database for papers dealing with drug treatment of OCD, with a specific focus on clinical guidelines, treatments with antidepressants, antipsychotics, mood stabilizers, off-label medications, and pharmacogenomics.

Results:

Prolonged administration of selective serotonin reuptake inhibitors (SSRIs) is most effective. Better results can be obtained with a SSRI combined with cognitive behavioral therapy (CBT) or the similarly oriented exposure and response prevention (ERP). Refractory OCD could be treated with different strategies, including a switch to another SSRI or clomipramine, or augmentation with an atypical antipsychotic. The addition of medications other than antipsychotics or intravenous antidepressant administration needs further investigation, as the evidence is inconsistent. Pharmacogenomics and personalization of therapy could reduce treatment resistance.

Conclusion:

SSRI/clomipramine in combination with CBT/ERP is associated with the optimal response compared to each treatment alone or to other treatments. New strategies for refractory OCD are needed. The role of pharmacogenomics could become preponderant in the coming years.
Gender Differences in Types, Frequency, Clinical Manifestations and Atherosclerotic Burden of Coronary Artery Anomalies
Authors: Yousif Nooraldaem , Shahin Mohammady , Lüscher Thomas F. , Obeid Slayman
Published: August 2018

Background:

Although not well established; gender may play a role in the incidence, clinical
manifestations, and atherosclerotic burden of Coronary Artery Anomalies (CAAS). Our aim is to
investigate the impact of gender on coronary artery anomalies.

Methods: All coronary angiograms performed at the University Heart Center Zurich, Switzerland, between
January 2000 and December 2016 were investigated. Those of anomalous origin, course and
termination (fistula) were included in the analysis with the exclusion of coronary artery aneurysms and
myocardial bridges.

Results:

Out of the original 39577 angiographic studies that included 28550 males and 11026 females,
Coronary Artery Anomalies (CAAS) were documented in 130 (0.32%) patients of whom 69.2%
(n=90) and 30.8%(n=40) were males and females respectively. However, the overall prevalence of
coronary anomalies amongst both genders did not differ (0.32% vs 0.36%, P = 1) and so were the
basic characteristics except for hypertension, which was more prevalent in females (P = 0.03644). The
most prevalent anomaly overall was (left circumflex artery from right coronary artery/sinus), which
was present in (n=47, 36.2%). No impact of gender on the incidence of individual anomalies except
for Right Coronary Artery (RCA) originating from Left Circumflex Artery (LCX), which was only
documented in men (P = 0.0000116). On the other hand malignant CAAS presented equally with a
proportion of 10% for both genders (P = 1). Although males outnumbered females in terms of atherosclerotic
burden in CAAS this was statistically not significant (P = 0.331).

Conclusion:

Both genders have a similar impact on the overall prevalence, clinical manifestations and
atherosclerotic burden of CAAs. Anomaly of RCA originating from LCX occurred more frequently in
males than females.
Recent Advances of Useful Cell Sources in the Periodontal Regeneration
Authors: Cho Young-Dan , Kim Kyoung-Hwa , Ryoo Hyun-Mo , Lee Yong-Moo , Ku Young , Seol Yang-Jo
Published: August 2018

Background:

Periodontitis is an inflammatory disease that can result in destruction of the
tooth attachment apparatus. Therefore, periodontal tissue regeneration is currently an important focus of
research in the field. Approaches using stem cells and reprogrammed cells, such as induced pluripotent
stem cells (iPSCs) or trans-differentiated cells, represent the cutting edge in periodontal regeneration,
and have led to many trials for their clinical application.

Objectives and Results:

In this review, we consider all available stem cell sources, methods to obtain
the cells, their capability to differentiate into the desired cells, and the extent of their utilization in
periodontal regeneration. In addition, we introduce the new concepts of using iPSCs and transdifferentiated
cells for periodontal regeneration. Finally, we discuss the promise of tissue engineering
for improving cell therapy outcomes for periodontal regeneration.

Conclusions:

Despite their limitations, iPSCs and trans-differentiated cells may be promising cell
sources for periodontal tissue regeneration. Further collaborative investigation is required for the effective
and safe application of these cells in combination with tissue engineering elements, like scaffolds
and biosignals.
Recent Advances in the Discovery of Novel Peptide Inhibitors Targeting 26S Proteasome
Authors: Gu Xinjie , Ma Shutao
Published: August 2018

Background:

The 26S proteasome is a proteolytic complex of multimeric protease, which operates at
the executive end of the Ubiquitin-Proteasome System (UPS) and degrades the polyubiquitylated proteins.

Methods:

After a brief introduction of 26S proteasome and Ubiquitin-Proteasome System (UPS), this review
focuses on the structure and function of the 26S proteasome in intracellular protein level regulation. Then,
physiological regulation mechanisms and processes are elaborated. In addition, the advantages and defects of
approved 26S proteasome inhibitors were discussed. Finally, we summarized the novel peptide 26S proteasome
inhibitors according to their structural classifications, highlighting their design strategies, inhibitory activity and
Structure-Activity Relationships (SARs).

Results:

Cellular function maintenance relies on the proteasome metabolizing intracellular proteins to control
intracellular protein levels, which is especially important for cancer cells to survive and proliferate. In primary
tumors, proteasomes had a higher level and more potent activity. Currently, the approved small peptide inhibitors
have proved their specific 26S proteasome inhibitory effects and considerable antitumor activities, but with
obvious defects. Increasingly, novel peptide inhibitors are emerging and possess promising values in cancer
therapy.

Conclusion:

Overall, the 26S proteasome is an efficient therapeutic target and novel 26S proteasome inhibitors
hold potency for cancer therapy.
Vigilance States: Central Neural Pathways, Neurotransmitters and Neurohormones
Authors: Iovino Michele , Messana Tullio , De Pergola Giovanni , Iovino Emanuela , Guastamacchia Edoardo , Giagulli Vito Angelo , Triggiani Vincenzo
Published: August 2018

Background and Objective: The sleep-wake cycle is characterized by a circadian rhythm involving neurotransmitters and neurohormones that are released from brainstem nuclei and hypothalamus. The aim of this review is to analyze the role played by central neural pathways, neurotransmitters and neurohormones in the regulation of vigilance states.

Method:

We analyzed the literature identifying relevant articles dealing with central neural pathways, neurotransmitters and neurohormones involved in the control of wakefulness and sleep.

Results:

The reticular activating system is the key center in the control of the states of wakefulness and sleep via alertness and hypnogenic centers. Neurotransmitters and neurohormones interplay during the dark-light cycle in order to maintain a normal plasmatic concentration of ions, proteins and peripheral hormones, and behavioral state control.

Conclusion:

An updated description of pathways, neurotransmitters and neurohormones involved in the regulation of vigilance states has been depicted.
Prevalence of Methicillin Resistant and Virulence Determinants in Clinical Isolates of Staphylococcus aureus
Authors: Chavadi Manjunath , Narasanna Rahul , Chavan Ashajyothi , Oli Ajay Kumar , Kelmani. R Chandrakanth
Published: August 2018

Introduction:

Methicillin-resistant Staphylococcus aureus (MRSA) is the major threat that is a result of the uncontrolled use of antibiotics causing a huge loss in health, so understanding their prevalence is necessary as a public health measure.

Objective:

The aim of this study was to determine the prevalence of methicillin-resistant MRSA and virulence determinant among associated S. aureus from the clinical samples obtained from various hospital and health care centers of the Gulbarga region in India.

Materials and Methods:

All the collected samples were subjected for the screening of S. aureus and were further characterized by conventional and molecular methods including their antibiotic profiling. Further, the response of methicillin antibiotic on cell morphology was studied using scanning electron microscopy.

Results:

A total 126 S. aureus was isolated from the clinical samples which showed, 100% resistant to penicillin, 55.5% to oxacillin, 75.3% to ampicillin, 70.6% to streptomycin, 66.6% to gentamicin, 8.7% to vancomycin and 6.3% to teicoplanin. The selected MRSA strains were found to possess mecA (gene coding for penicillin-binding protein 2A) and femA (factor essential for methicillin resistance) genetic determinants in their genome with virulence determinants such as Coagulase (coa) and the X region of the protein A (spa) gene. Further, the methicillin response in resistant S. aureus showed to be enlarged and malformed on cell morphology.

Conclusion:

The molecular typing of clinical isolates of S. aureus in this study was highly virulent and also resistant to methicillin; this will assist health professionals to control, exploration of alternative medicines and new approaches to combat Staphylococcal infections more efficiently by using targeted therapy.
Functional Exploration Of T-Type Calcium Channels (Cav3.2 And Cav3.3) And Their Sensitivity To Zinc
Authors: Hazzaz Abouamal Tahar , Choukairi Zineb , Taoufiq Fechtali
Published: August 2018

Introduction:

T-type Ca2+ channels (TTCC) are low Voltage-gated calcium channels, expressed in various tissues such as the brain and heart, and contribute to a variety of physiological functions including neuronal excitability, hormone secretion, muscle contraction, and pacemaker activity. At high concentrations, Zinc (Zn2+) is naturally attached to cell membranes and is therefore considered a reversible inhibitor of calcium. Zinc is also involved in the kinetics of sodium and potassium currents. Zinc is essential for many functions. A low zinc tenor is associated with emotional instability, digestive disorders, slow-growing and alteration of protein synthesis.

Material and Methods:

For the Cell Culture we used HEK-293/tsA-201, and for transfection, the pCDNA3 plasmid constructs encoding human CaV3.2, and CaV3.3 subunits. Electrophysiological experiments were performed using the whole cell configuration of the patch-clamp technique. T-type currents were recorded using a test pulse from a holding potential at (-100mV) to (-30 mV), data Acquisition and Analysis for Current-voltage relationships (I-V curves) were recorded for the two cloned T-type Ca2+ channels (Cav3.2, Cav3.3).

Results:

Our studies describe the behavior of these channels Cav3.2 and Cav3.3 and also their current sensitivity to Zinc (Zn2+) in transfected HEK-293/tsA-201cells. Our results show that Zn2+ applies a modulatory effect on T-type calcium channels. We observe that Zn2+ differentially modulates the CaV3.2 and CaV3.3 channels. Zn2+ preferably inhibits Cav3.2.

Conclusion:

We have demonstrated that Zn2+ differentially modulates two CaV3 channels (Cav3.2 and Cav3.3): It is a preferential blocker of CaV3.2 channels and it alters the gating behaviour of CaV3.3 channels.
Community's Participation: A strategic approach in revitalizing heritage streets
Authors: Mohd Yunus Rodzyah , Samadi Zalina , Omar Dasimah
Published: August 2018

City dynamic often dominates by street shoppers, pedestrian and vehicular traffics. The dynamic ambiance in heritage streets is not an impromptu scenario but a value innovation from the street's committee. The first objective of this research is to identify the street's committee's strategy, the second is to classify their strategies and the third is to compare and find the best strategies. The evaluation on strategies is analyzed from the semi-structured interview and content analysis. Finally, a consensus of a strategy in the making of successful heritage street as an innovative marketplace is produced in capitalizing heritage tourism endeavor.
Cross-Cultural Ecosystem Services: How Taiwanese and Amis live with rivers?
Authors: Chang Shenglin Elijah
Published: August 2018

Cultural ecosystem service has been a raising field since  2010. While interdisciplinary research teams investigate cultural ecosystem services via humanity lenses, most CES studies focus on mono-cultural settings. The study compares the Taiwanese Han-culture waterfront recreational patterns to the Ames tribal aqua-cultural habitat patterns. It suggests the community participatory mechanisms for re-vision the Danshui River ecosystems. It argues that the river ecosystem could support cross-cultural lifestyles for Ames tribes if the government officials and design-planning professions could alter their approaches of waterfront planning, design, and governance. The research sheds the light on multi-cultural environments in our global world.
Developing Urban Environment by Focusing on Human Thermal & Wind Comfort: A literature review
Authors: Ghasemi Zahra , Esfahani Mahnaz Asemi , Bisadi Mona
Published: August 2018

This paper survey importance of urban open spaces and effective parameters on people attendance. In the recent years, low-quality environments have caused a low level of people attendance in that places and subsequently, lots of different problems in human life. One of the determining factors affecting the quality of the environment is providing human comfort. This paper discusses human comfort features. The aim of this article is presentation guidelines based on the creation of the wind and thermal comfort in urban open spaces. According to the fact, by the presence of comfort we can return people to urban open spaces. We derived some conceptual frameworks and categorized them on a chart. The table is divided into four climatic regions based on Iran climatology, to lead architects, urban planners for designing desirable spaces.
Generation Y and Job Performance: SMEs in Malaysia
Authors: Jalil Susana William , Achan Pauline , Mojolou Dean Nelson , Rozaimie Awang
Published: August 2018

The aim of the present study is to examine the impact of personal characteristics namely: physical activity, smoking, drinking, and duration of computer use before taking breaks on performance at work of the 'Generation Y' who employed in the Malaysian SMEs. The correlation analyses performed in order to gauge the relationship between individual characteristics and the performance of the 67 respondents who were working at the various SMEs. The key finding indicates that smoking found to have the highest effect. Therefore, this study filled the research gap pertaining to the effective management of manpower in the Malaysian SMEs.
Public Perception on Cultural Perspective
Authors: Idilfitri Sabrina , Mohd Rodzi Nur Izzati , Nik Mohamad Nik Hanita , Sulaiman Suria
Published: August 2018

A better quality of urban life can be achieved with one of the best planning method; public perception. The local communities and the tourists are the groups that are identified as the most influence and affected individual in an area and give the tremendous boost to any development. The research aim is to obtain the level of awareness and appreciation of these groups toward the cultural attraction. It is envisaged that the analysis will further contribute to the knowledge and idea of professional disciplinary. The findings are hoped to contribute towards establishing the preservation of cultural attractions including architecture, religion attraction, and natural environmental setting.
Regeneration of Road Users Using PreSiM Model
Authors: Masuri Mohamad Ghazali , Dahlan Akehsan , Danis Ajau , Md Isa Khairil Anuar
Published: August 2018

This study was involved in-one-to-one depth interview. Seven road users who had experienced road traffic accident were interviewed using semi-structured questionnaire. Data then analyzed using the Atlas.ti software. The themes that emerged shows that majority of the respondent agreed that to maintain driver's competency, there is a need to re-assess, and all qualified drivers and high-risk drivers may need to attend driving rehabilitation program in the future. The data was translated into a proposed model called PreSiM. This study concluded that human components have a high potential to be re-evaluated in the current licensing process.
Self-Directed Learning Improves Quality of Life
Authors: Din Noorriati , Haron Shireen , Mohd Rashid Rahmah
Published: August 2018

The SeDLE (Self-directed Learning Environment) Index is developed to measure the strength and ability of the learning environment to facilitate self-directed learning. This is a conceptual paper to explain the development and validation of the SeDLE index. Evidence showed that a self-directed learning environment exhibits a self-directed learner in promoting one's quality of life. The self-directed environment will support and inhibit the ability to function with less supervision among learners thus viewed as a solution to reduce the problem of spoon feeding in the classrooms.
Students' Intentions and Student' Attainments at the On-campus House: A desk study
Authors: Mohd Najib Nurul 'Ulyani , Yusof Nor'Aini , Tabassi Amin Akhavan
Published: August 2018

There is large call in Malaysia to study on how tertiary students perceived the performance of service quality of student housing; and to understand on how they translated their perceptions into behavioural intentions and personal attainments. The rationale for this paper is to explain the elements which constitute behavioural intentions and personal attainments; which is based on conventional reviews of plentiful volume of published journals from 1985 until 2014 in the area of student housing research. The results of the review clarified that behavioural intentions consist of favourable and unfavourable intentions; while personal attainments comprise of intellectual and self-development gains.
Not Just a Medical Student: Delivering Medical Education Through a Short Video Series on Social Media (Preprint)
Authors: Abbas Nadine , Ojha Utkarsh
Published: August 2018

UNSTRUCTURED

“Not Just a Medical Student” is an innovative bite-size medical education video series founded and hosted on social media. Its primary aim is to inspire tomorrow’s doctors to be creative while engaging and informing them with the latest innovations, technology, and conferences within various specialties. To our knowledge, these themes are scarcely covered in the structured medical curriculum. Created and launched in August 2017, “Not Just a Medical Student” quickly gained traction; with over 1000 followers on Facebook and a rapidly increasing number of views, it reached the medical community across the globe. The video series features a trailblazer in virtual reality surgery and its potential impact on the evolution of medical education, reviewing future medical technology apps, such as Touch Surgery, and reporting on the latest medical education and health apps. The series engaged in topical medico-politics at the British Medical Association House and reported on global health issues and innovations at the Royal Society of Medicine Conference. The video series has further received several national awards including the Association and Study of Medical Education (ASME) Educator Innovator 2017 award, runner up to the Zeshan Qureshi Outstanding Contribution to Medical Education Award, and the Alternative Docs National Social Media Influencer award. The concept has been presented at international conferences (eg, the Healthcare Leadership Academy conference) and gained international recognition upon personal invitation at the Norwegian Annual Junior Doctors Conference. With the rise of the social media generation, innovative methods to inspire, engage, and inform students contributing to the continuous evolution of medical education should be encouraged and further explored.
Environmentally Friendly Apparel Products: The Effects of Value Perceptions
Authors: Moon Heekang , Lee Hyun-Hwa
Published: August 2018

The aim of the study was to investigate consumers' value perceptions of apparel companies' activities in regard to environmentally friendly apparel products. We recruited women living in USA to obtain 593 responses for statistical analysis of the data. The results suggest that the fit
between environmentally friendly products and a fast fashion brand is important for fashion consumers, and a good fit of the fast fashion brand with sustainability causes increases consumers' perceptions of the fit between the parent brand and the sustainable extension line. Consumers' perceptions
of cause-effectiveness value and monetary value of the extension line were each found to have an impact on both their purchase intention and their willingness to pay a premium price. These findings contribute to both academia and fast fashion retailers interested in corporate social responsibility.
Loyal Customer Behaviors: Identifying Brand Fans
Authors: Ho Lee Seong , Jung Kyung Sik
Published: August 2018

Using concepts of self-image congruence and involvement, we investigated whether existing customers can be considered brand fans and, if so, how to determine the behavior of brand fans in various situations. Participants were 180 students in a business administration marketing program
in South Korea with strong brand loyalty. Cluster analysis was conducted using a 2 (high vs. low self-image congruence) × 2 (high vs. low involvement) analysis of variance and paired t tests were used to identify brand fans through fanship and switching intentions (Study 1). Then
we investigated how participants' minds changed after being exposed to a negative article (Study 2) and a competitor's aggressive marketing (Study 3). We found that fans do exist for commercial brands and that, as assumed, image congruence and involvement are critical constructs. These results
suggest that consideration of image congruence and involvement is necessary for businesses to secure and foster brand fans.
Perceived Supervisor Support as a Mediator Between Chinese University Teachers' Organizational Justice and Affective Commitment
Authors: Li Yongzhan , Castaño Gloria , Li Yongxin
Published: August 2018

We explored the effects of perceptions of supervisor support and organizational justice on affective commitment among 420 university teachers at 5 universities in China. Structural equation modeling and bootstrapping analysis were used to test our hypotheses. The results showed that
university teachers' perception of organizational justice positively influenced their affective commitment, and perceived supervisor support partially mediated this relationship. This study advances the understanding of the mechanism driving university teachers' affective commitment; our findings
indicate that observing the principle of justice and offering supervisor support fosters Chinese university teachers' organizational commitment.
A Moderated Mediation Model of Supplication Tactics Toward Coworkers and Leader–Member Exchange
Authors: Chuang Shuang-Shii , Shih Chih-Ting , Chen Hsu-Yao , Lin Cheng-Chen (Timothy) , Teng Yu-Lin
Published: August 2018

Previous researchers of impression management have focused on the tactics of supervisor-targeted ingratiation, self-promotion, and exemplification, and neglected those targeting coworkers. Thus, we focused on the supplication tactics that employees use toward coworkers. Data were collected
from 238 supervisor–subordinate dyads working at technology companies in Taiwan. Results showed that the higher the self-efficacy, the less likely employees were to use supplication tactics. This negative relationship was also stronger when leader–member exchange (LMX) quality
was high. However, when employees used supplication tactics, high LMX did not buffer supervisors' negative assessment of their organizational citizenship behavior (OCB). Thus, employees' supplication tactics damaged supervisors' evaluation of their OCB. Theoretical and practical implications
are discussed.
FORMULATION AND EVALUATION OF FAST DISSOLVING ORAL FILM OF ANTI-ALLERGIC DRUG
Authors: LINKU ABRAHAM , SIJIMOL JOSEPH
Published: August 2018

The aim of present work was the development of fast dissolving oral film of Loratadine to overcome the limitations of current routes of administration, to provide immediate action and increase the patient compliance. To improve the bioavailability of the drug, fast dissolving oral film were formulated using different grades of Hydroxy Propyl Methyl Cellulose(HPMC) and various plasticizers like Polyethylene Glycol(PEG) 400, glycerol, Propylene glycol(PG) by solvent casting method. The formulated films were evaluated for film thickness, surface pH, folding endurance, weight variation, % moisture loss, exvivo permeation study, tensile strength, % elongation, drug content uniformity, in vitro dissolution studies,in vitro disintegration test and in vivo study. The optimized formulation (F9) containing HPMC E5 and glycerol showed minimum disintegration time (10.5 s), highest in vitrodissolution (92.5%) and satisfactory stability. Ex vivo permeation study of optimized formulation showed a drug release of 80.6% within 10 min. The milk induced leucocytosis inrat proved that fast dissolving oral films of Loratadine produced a faster onset of action compared to the conventional tablets. These findings suggest that fast dissolving oral film of Loratadine could be potentially useful for treatment of allergy where quick onset of action is required.
ANTIINFLAMMATION ACTIVITY ETHANOL EXTRACT OF MARBOSI-BOSI LEAVES (Tarenna polycarpa (Miq.) Koord.Ex Valeton) ON WHITE RAT IN CARRAGEENAN INDUCED PAW INFLAMMATION
Authors: Munandarnst Haris , N Marline
Published: August 2018

Traditionally, (Tarenna polycarpa (Miq.) Koord Ex Valeton as known as marbosi-bosi which commonly found in Sibolga, North Sumatera, Indonesia has been used as antidiabetes, cholesterol, anti-inflammatory and antibacterial. Tarenna species has been found its activities as antimicrobial, anti-oxidant and anti-inflammatory activity. The aim of this study was to investigate the anti inflammatory effect ethanol extract of marbosi-bosi leaves (Tarenna polycarpa (Miq.) Koord Ex Valeton in terms of decreased edema volume of male white rat in 1% carrageenan-induced and also to determine the effective dose of extract to decrease the volume of rat paw edema Ethanol extract of marbosi-bosi (Tarenna polycarpa (Miq.) Koord Ex Valeton was obtained by maceration. The antiinflammatory activity test was divided into 5 groups. The Group I (negative control) was given CMC 0.5%, Group II (positive control) was given diclofenac sodium 2,25 mg / kg BW, while Group III, IV and V were  given marbosi-bosi leaf extract at a dose of 50, 100 and 200 mg/kgBW respectively.  Each rat was induced by 1% carrageenan subplantar injection. Examination of antiinflammatory effect was measured by using digital plethysmometer at minute of 30 to minute of 360. The data were analyzed statistically using ANOVA (analysis of variance).The results showed that negative control did not show anti-inflammatory effect had significant differences with other treatment groups. In conclusion, ethanol extract marbosi-bosi (Tarenna polycarpa (Miq.) Koord Ex Valeton has an effective anti-inflammatory activity at a dose of 100 mg / kgBW.
Preparation and Evaluation of Beta sitosterol Nanogel: A Carrier Design for Targeted Drug Delivery system
Authors: Inamdar Yashashri Mohan , Rane Bhushan , Jain Ashish
Published: August 2018

Transdermal drug delivery system is promising but challenging system available for local as well as systemic effect of the drug. The prolonged residence of drug formulation in the skin is important for transdermal drug delivery. Nanogel drug delivery has remained as one of the most challenging task. The objective of the investigation was to develop a nanogel with reduced particle size in order to improve the bioavailability of the hydrophobic drug. The objective of the controlled and sustained delivery is to provide and maintained adequate concentration of drugs at the site of action. Nanogels based materials have high drug loading capacity, biocompatibility and biodegradability which are key points to design the drug delivery system effectively. Drug molecules loaded into the nanogel need to be retained and not to be transported out or leak prematurely while circulating in order to provide maximum therapeutic effects and minimum toxicity or side effects. The present study is to formulate nanosizes dispersion of Beta sitosterol by nanoprecipitation method and incorporating it into the gelling agent to produce nanogel by dispersion method. 1% of carbopol 934 shows better in-vitro drug release than the other concentrations of carbopol 934.
TDABC: Lessons from an Application in Healthcare
Authors: Balakrishnan Ramji , Koehler Daniel M. , Shah Apurva S.
Published: August 2018

SYNOPSIS

We estimate the costs of two substitutable medical procedures in a hospital as reported by a conventional two-stage system and from using TDABC concepts. Comparisons yield insights into the data needs for both systems, and practical issues that arise when implementing TDABC in an organization with a complex cost structure. As “lessons learned,” we list four insights relating to simplifying the data needs of a TDABC system. We also discuss how features of the traditional system influence the differences in the cost estimates from the two approaches. Based on our experience, we offer suggestions on how organizations might be able reap many of the benefits associated with TDABC without an overhaul of the entire costing system.

JEL Classifications: M41; I19.

Data Availability: Data are proprietary to the research site and are not publicly available.
Financial Statement Footnote Readability and Corporate Audit Outcomes
Authors: Abernathy John L. , Guo Feng , Kubick Thomas R. , Masli Adi
Published: August 2018

We examine whether the readability of financial statement footnotes in the annual report is informative about audit engagement risk. Using various readability measures, we predict and find that firms with less readable footnotes have longer audit report lag, incur higher audit fees, and are more likely to receive a first time modified going concern opinion. We also show that readability of footnotes is associated with a higher likelihood of financial misstatements and future accounting-related litigation. Our results are robust to several measures of readability used in prior literature, as well as different specifications and design choices, revealing that financial statement footnote readability provides incremental information about audit engagement risk that affects auditor-client contracting.

Data Availability: Data are obtained from public sources identified in the paper.
Facilitating Citizens' Voice and Process Reengineering Using a Cloud-Based Mobile App
Authors: O'Leary Daniel E.
Published: August 2018

Recently, the City of Boston implemented a mobile, cloud-based app. Originally called “Citizens Connect,” but now called “Bos:311,” the app allows citizens to report issues related to the city's infrastructure, e.g., graffiti. Rich information in the form of pictures and descriptions provided from mobile devices, along with GPS location information, facilitates crowdsourcing monitoring of the city's infrastructure. This app provides “straight through” processing of citizen requests, reengineering the processes of monitoring and fixing city infrastructure. As a result, operations and management accounting information can be more accurate and used in real time. In addition, the cloud-based capture of information from multiple cities allows comparisons and benchmarking of critical information that likely would not be possible in other settings, while allowing economic system use by large numbers of users. This paper investigates a number of hypotheses about the use of the mobile app generated from both Hirschman's and Hammer's theories.
Using Sociological Theories and Concepts in Accounting Information Systems Research: A Framework for Team Research
Authors: Weisner Martin M.
Published: August 2018

This article presents a selection of sociological theories and concepts with potential for application by researchers interested in audit firm teams consisting of, or including, IT specialists and the technologies supporting those teams. A framework structured around intragroup collaboration, intergroup collaboration, and team control is presented, along with a series of research questions that link sociological perspectives with accounting research. The study is motivated by calls for expansion of theoretical perspectives through which accounting research can be approached, and aims to assist researchers in addressing the scarcity of sociologically informed inquiry in the domain of group processes, team dynamics, and related team management concerns.