bluuebunny/crossref_metadata_2025 huggingface dataset:
A high protein low glycemic index diet has no adverse effect on blood pressure in pregnant women with overweight or obesity: a secondary data analysis of a randomized clinical trial
Authors: Larson Elisabeth A. , Magkos Faidon , Zingenberg Helle , Svare Jens , Astrup Arne , Geiker Nina R. W.
Published: November 2023

Objectives

The objective of this analysis was to evaluate the effect of a diet rich in animal protein and low in glycemic index on blood pressure during pregnancy.

Design

This post hoc, secondary data analysis of a randomized controlled trial, evaluated blood pressure in pregnant participants who were randomized either to an ad libitum diet with high protein and low glycemic index, rich in dairy and seafood, or an ad libitum control diet according to national recommendations.

Setting

The study occurred in pregnant women in Copenhagen, Denmark.

Sample

A total of 279 pregnant females with overweight or obesity were enrolled.

Methods and outcome measure

Blood pressure was measured at 5 timepoints during pregnancy from gestational week 15 through week 36, and blood pressure between groups was compared.

Results

There were no differences between diet arms in systolic or diastolic blood pressure over time. There were also no differences in most blood-pressure-related pregnancy complications, including the prevalence of premature birth, preeclampsia, or hypertension, but the frequency of total cesarean sections was lower in the active than the control group (16 out of 104 vs. 30 out of 104) (p = 0.02).

Conclusion

Increased animal protein intake was not associated with changes in blood pressure in pregnant women with overweight or obesity.

Clinical trial registration

[ClinicalTrials.gov], identifier [NCT01894139].
TPD52L2 as a potential prognostic and immunotherapy biomarker in clear cell renal cell carcinoma
Authors: Wang Hongbo , Liu Zhendong , Du Yuelin , Cheng Xingbo , Gao Shanjun , Gao Yanzheng , Shang Panfeng
Published: November 2023

Background

Tumor Protein D52-Like 2 (TPD52L2) is a tumor-associated protein that participates in B-cell differentiation. However, the role of TPD52L2 in the pathological process of clear cell renal cell carcinoma (ccRCC) is unclear.

Methods

Multiple omics data of ccRCC samples were obtained from public databases, and 5 pairs of ccRCC tissue samples were collected from the operating room. Wilcox, chi-square test, Kaplan-Meier method, receiver operating characteristic curve, regression analysis, meta-analysis, and correlation analysis were used to clarify the relationship of TPD52L2 with clinical features, prognosis, and immune microenvironment. Functional enrichment analysis was performed to reveal the potential pathways in which TPD52L2 participates in the progression of ccRCC. The siRNA technique was used to knockdown in the expression level of TPD52L2 in 786-O cells to verify its effect on ccRCC progression.

Results

First, TPD52L2 was found to be upregulated in ccRCC at both mRNA and protein levels. Second, TPD52L2 was significantly associated with poor prognosis and served as an independent prognostic factor. Moreover, TPD52L2 expression was regulated by DNA methylation, and some methylation sites were associated with ccRCC prognosis. Third, TPD52L2 overexpression may participate in the pathological process through various signaling pathways such as cytokine-cytokine receptor interactions, PI3K-Akt, IL-17, Wnt, Hippo signaling pathway, and ECM-receptor interactions. Interestingly, TPD52L2 expression level was also closely related to the abundance of various immune cells, immune checkpoint expression, and TMB. Finally, in vitro experiments confirmed that knocking down TPD52L2 can inhibit the proliferation, migration, and invasion abilities of ccRCC cells.

Conclusion

This study for the first time revealed the upregulation of TPD52L2 expression in ccRCC, which is closely associated with poor prognosis of patients and is a potentially valuable therapeutic and efficacy assessment target for immunotherapy.
Anlotinib combined with transarterial chemoembolization for unresectable hepatocellular carcinoma associated with hepatitis B virus: a retrospective controlled study
Authors: Chen Song , Cai Hongjie , Wu Zhiqiang , Tang Shuangyan , Chen Ludan , Wang Fan , Zhuang Wenquan , Guo Wenbo
Published: November 2023

Purpose

To investigate the efficacy and safety of combined treatment of anlotinib and transarterial chemoembolization (TACE) in patients with unresectable hepatocellular carcinoma (uHCC) associated with hepatitis B virus (HBV) infection.

Methods

We retrospectively collected the data of 96 uHCC patients associated with HBV infection who received either TACE only (TO group; n = 64) or anlotinib combined with TACE (TA group; n = 32) from January 2017 to January 2021. The primary endpoint was overall survival (OS). The secondary outcomes included progression-free survival (PFS), tumor response according to modified Response Evaluation Criteria in Solid Tumors (mRECIST) and RECIST 1.1, and adverse events (AEs).

Results

The median OS and median PFS were significantly longer in the TA group compared to the TO group (17.6 months vs. 9.4 months, p = 0.018; 6.7 months vs. 3.8 months, p = 0.003, respectively). In addition, the overall objective response rate (ORR) and disease control rate (DCR) numerically increased in the TA group (mRECIST, ORR 65.6% vs. 46.9%, p = 0.064, DCR 90.6% vs. 85.9%, p = 0.382; RECIST 1.1, ORR 46.9% vs. 15.6%, p = 0.001, DCR 90.6% vs. 85.9%, p = 0.382, respectively). It was worth noting that no treatment-related mortality occurred during the study. The most common AEs included elevated transaminases (56.3%), decreased appetite (46.9%), and abdominal pain (37.5%) in the TA group. Although the incidence rate of grade 3/4 AEs was higher in the TA group, all of them were controllable.

Conclusions

The combination of anlotinib and TACE has shown promising results in improving outcomes for patients with HBV-related uHCC, as compared to TACE monotherapy. In addition, this combination therapy has demonstrated a controllable safety profile. However, further validation is urgently needed through randomized controlled trials with large sample sizes.
Differentiation between small hepatocellular carcinoma (<3 cm) and benign hepatocellular lesions in patients with Budd-Chiari syndrome: the role of multiparametric MR imaging
Authors: Zandieh Ghazal , Shahbazian Haneyeh , Tang Hao , Wu Qingxia , Shaghaghi Mohammadreza , Hazhirkarzar Bita , Baghdadi Azarakhsh , Afyouni Shadi , Verde Franco , Pawlik Timothy , Kamel Ihab
Published: November 2023

Objective

To investigate the value of multiparametric MR imaging to differentiate between small hepatocellular carcinoma (s-HCC) versus benign liver lesions in patients with Budd-Chiari syndrome.

Methods

12 patients with benign hepatocellular lesions and 32 patients with small (<3 cm) HCCs were assessed. MRI images were reviewed by two radiologists blinded to the patient background information; lesion T1 and T2 signal intensities and ADC values were compared with the background liver. Enhancement of lesion relative to hepatic parenchyma [(T1Enh-T1liver)/T1liver] in the arterial, venous, and delayed phases was also compared between the two groups. A multivariable logistic model was developed using these categorical measures; the predictive value of the model was tested using the Area Under the Receiver operating characteristic (AU-ROC) curve for logistic models. P-values <0.05 were considered statistically significant.

Results

There were consistent differences in T1lesion/T1liver, and T2lesion/T2liver, and ADClesion/ADCliver between benign hepatocellular lesions versus the sHCC group (p<0.001, p<0.001, p = 0.045, respectively). Lesion-to-background liver enhancement in the portal venous and delayed phases was different between the benign lesions versus sHCC (p=0.001). ROC analysis for the logistic model that included the T1 ratio, T2 ratio, and portal venous enhancement ratio demonstrated excellent discriminatory power with the area under the curve of 0.94.

Conclusion

Multiparametric MR imaging is a useful method to help differentiate benign liver lesions from sHCC in patients with Budd-Chiari syndrome.
Potential impact of ocular intense pulsed light on eyelash microbiome in severe meibomian gland dysfunction: report of 2 cases
Authors: Somboonna Naraporn , Wongsaroj Lampet , Watthanathirakawi Attawut , Wanumkarng Nattawut , Iam-a-non Anchana , Pongpirul Krit
Published: November 2023

Meibomian gland dysfunction (MGD) is a prevalent worldwide eye disorder that causes eye irritation, inflammation, chronic dryness, and blurred vision. Traditional therapies offer temporary improvement, but their efficacy varies in severe MGD cases. Ocular intense pulsed light (IPL) has emerged as a novel therapy, providing long-term symptom relief and shorter treatment durations compared to traditional approaches. However, the impact of IPL on the bacterial community within the eyes remains limited. To address this, we conducted a preliminary study using metagenomics and next-generation sequencing. We compared the bacterial eyelash communities of Thai females with severe MGD before and after 2-4 IPL treatments, and against a group of healthy females. Our findings revealed higher bacterial diversity in healthy individuals compared to severe MGD cases. IPL treatments increased diversity in the MGD group, making their core bacterial community more similar to that of healthy subjects. Notably, the presence of Koribacteraceae in severe MGD and Bifidobacterium in healthy individuals and post-IPL-treated MGD exemplified this shift. Clustering analysis showed a closer relationship between post-IPL-treated MGH and healthy subjects, while the pre-IPL treatment group formed a separate branch. These results suggest that IPL treatment can reshape the eyelash microbiome in MGD cases, but further research is needed to understand the implications and the microbiome’s role in MGD pathogenesis and treatment response.
Orbital fractures and concurrent ocular injury in a New Zealand tertiary centre
Authors: Theis Nicholas J. , Narsinh Pritesh , Newlands Samuel , Erasmus Jason , Stack Rebecca
Published: November 2023

Background

Orbital fractures are a common presentation to acute care and carry an associated risk of ocular injury, however, previous research has not investigated injury rates by fracture category. These patients are frequently assessed by non-ophthalmic clinicians, however, limited data exists regarding referral patterns and how this impacts recorded injury rates (1–3).

Methods

We performed a retrospective review of all orbital fractures presenting to a tertiary hospital in Christchurch, New Zealand between March 2019 and March 2021. Data including mechanism of injury, fracture type, demographic characteristics, and associated ocular injury were recorded.

Results

284 patients with orbital fractures were identified. 41% of patients had isolated wall fractures, while 59% had complex orbitofacial fractures. Fractures were more common in males, and occurred more frequently in young individuals. The most common mechanism of injury was interpersonal violence (32%), followed by falls (23%). 41% of patients were reviewed by ophthalmology (n = 118). Of those, 33% had an associated ocular injury. Severe ocular injury (defined as vision threatening, requiring globe surgery or acute lateral canthotomy and cantholysis) occurred in 4.9% of those with formal ophthalmic review. 0.7% of patients required intraocular surgery or lateral canthotomy due to their orbital fracture.

Conclusion

Orbital fractures have a high rate of concurrent ocular injury in our study population, though rates of subsequent intraocular surgery are low. There was no significant difference in injury rates between isolated and complex fracture categories. Vision-threatening ocular injury occurred in 4.9% of fractures.
Role of the ortho-bridge system in the length unstable subtrochanteric femur fracture in school going children: a retrospective clinical study of 19 cases
Authors: Li Mingjing , Xu Jian , Xiang Jiang , Zhu Chunquan , Dai Zonghui , Li Fan
Published: November 2023

Background

Treating subtrochanteric femur fractures in pediatric patients remains challenging, and an optimal fixation device has yet to be established. This study aimed to asess the clinical and radiological outcomes of Ortho-Bridge System (OBS) treatment for length-unstable subtrochanteric femur fractures in children aged 5–16 years.

Methods

We conducted a retrospective review of pediatric patients with subtrochanteric femur fractures treated with OBS between January 2018 and December 2021. The study included 19 children (12 boys, 7 girls) with an average age of 10.4 ± 2.6 years. Two of the patients had pathological fractures associated with aneurysmal bone cyst. Demographic information, mechanism of accident, fracture type, associated neurovascular injuries, surgical duration and blood loss, were collected from the hospital database. Time to union and postoperative complications were recorded. Clinical and radiological outcomes were assessed using the Harris scoring system at the latest follow-up.

Results

Injuries resulted from vehicle accidents in 10 patients (52.6%), falls over 3 meters in height in 3 patients (15.8%), and sports-related injuries in 6 patients (31.6%). The average patient weight was 41.5 kg (range: 21–78). Of the fractures, 14 (73.7%) were complex, and 5 (26.3%) were spiral. The average surgical duration was 111 min (range: 90–180), and the average surgical blood loss was 134 ml (range: 70–300). The mean time to union was 12.7 weeks (range: 8–16). No cases of infection, malunion, implant failure, or femoral head osteonecrosis were reported. Leg length discrepancy of 10 mm was observed in one patient. All patients achieved excellent results according to the Harris scoring system.

Conclusion

This study suggests that the OBS may serve as an effective alternative fixation option for managing length-unstable subtrochanteric femur fractures in school-aged children.
Multi-level characteristics recognition of cancer core therapeutic targets and drug screening for a broader patient population
Authors: Su Yangguang , Wang Ying , Qu Zhuo , Liu Jiaxin , Ren Xuekun , Zhang Denan , Chen Xiujie
Published: November 2023

Introduction: Target therapy for cancer cell mutation has brought attention to several challenges in clinical applications, including limited therapeutic targets, less patient benefits, and susceptibility to acquired due to their clear biological mechanisms and high specificity in targeting cancers with specific mutations. However, the identification of truly lethal synthetic lethal therapeutic targets for cancer cells remains uncommon, primarily due to compensatory mechanisms.

Methods: In our pursuit of core therapeutic targets (CTTs) that exhibit extensive synthetic lethality in cancer and the corresponding potential drugs, we have developed a machine-learning model that utilizes multiple levels and dimensions of cancer characterization. This is achieved through the consideration of the transcriptional and post-transcriptional regulation of cancer-specific genes and the construction of a model that integrates statistics and machine learning. The model incorporates statistics such as Wilcoxon and Pearson, as well as random forest. Through WGCNA and network analysis, we identify hub genes in the SL network that serve as CTTs. Additionally, we establish regulatory networks for non-coding RNA (ncRNA) and drug-target interactions.

Results: Our model has uncovered 7277 potential SL interactions, while WGCNA has identified 13 gene modules. Through network analysis, we have identified 30 CTTs with the highest degree in these modules. Based on these CTTs, we have constructed networks for ncRNA regulation and drug targets. Furthermore, by applying the same process to lung cancer and renal cell carcinoma, we have identified corresponding CTTs and potential therapeutic drugs. We have also analyzed common therapeutic targets among all three cancers.

Discussion: The results of our study have broad applicability across various dimensions and histological data, as our model identifies potential therapeutic targets by learning multidimensional complex features from known synthetic lethal gene pairs. The incorporation of statistical screening and network analysis further enhances the confidence in these potential targets. Our approach provides novel theoretical insights and methodological support for the identification of CTTs and drugs in diverse types of cancer.
Prolonged repeated inseminations trigger a local immune response and accelerate aging of the uterovaginal junction in turkey hens
Authors: Kosonsiriluk Sunantha , Reed Kent M. , Noll Sally L. , Wileman Ben W. , Studniski Marissa M. , Boukherroub Kahina S.
Published: November 2023

Artificial insemination is a standard practice in the turkey breeder industry to ensure the production of fertile eggs. Even though hens are inseminated on a weekly basis, their fertility tends to decline after a few weeks of production. Avian species have a specialized structures called sperm storage tubules (SSTs), located in the uterovaginal junction (UVJ) of the oviduct. The ability of SSTs to store sperm is directly correlated with the fertility of the hen. The objective of the study was to examine changes in the transcriptome of the turkey hen’s UVJ in response to the presence of sperm at three key stages of production. We hypothesized that repeated and prolonged exposure to sperm would alter the transcriptome of the UVJ. Samples were collected from virgin hens prior to the onset of lay, as well as from sham-inseminated (extender only) and semen-inseminated hens at early lay, peak lay, and late lay. Gene expression profiling of the UVJ was examined, and a differential expression analysis was conducted through pairwise comparisons between semen- and sham-inseminated groups at each production stage and across production stages. In the early laying stage, no significant gene expression changes were found between semen- and sham-inseminated groups. However, at peak lay, genes related to lipid biosynthesis, Wnt signaling, cell proliferation, and O-glycan biosynthesis were upregulated in the semen group, while the immune response and cytokine-cytokine receptor interaction were downregulated. In the late lay stage, the transcription pathway was upregulated in the semen group, whereas the translation pathway was downregulated. The local immune response that was suppressed during peak lay was increased at the late laying stage. In the semen-inseminated group, the UVJ exhibited advanced aging at the late laying stage, evidenced by reduced telomere maintenance and translation processes. The results from this study provide valuable insights into the alteration of the UVJ function in response to the presence of sperm at different stages of production and throughout the production cycle. Targeting the modulation of local immune response and addressing aging processes after peak production could potentially prevent or delay the decline in fertility of turkey breeder hens.
Influence of the size of clonal fragment on the nitrogen turnover processes in a bamboo ecosystem
Authors: Zou Zan , Li Yang , Song Huixing
Published: November 2023

Different sizes of clonal fragments contain various number of ramets with different spacer lengths, which strongly affects the redistribution of photosynthetic assimilates. Although clonal integration significantly affects rhizosphere processes via microbial enzymes under heterogeneous conditions, the effects of clonal fragment size (ramet number and spacer length) on rhizosphere N turnover processes remain poorly understood. Here, we sampled clonal fragments of Phyllostachys bissetii with different ramet numbers and spacer lengths to determine the relative effects of clonal integration and fragment size on rhizosphere processes and resource availability. We found that clonal integration had positive effects on the C and N availability of shaded ramets in clonal fragments with different ramet numbers, owing to the large resource storage in the fragment. However, it only promoted the dissolved organic carbon of the shaded ramets in clonal fragments with different spacer lengths. Results of regression analyses indicated that the response ratios of the soil variables of the shaded ramets first increased when the spacer length was about less than 30 cm and then decreased when the spacer became longer (about >30 cm), suggesting a cost–benefit tradeoff in the fragment. The contribution of the size of clonal fragment to the soil N turnover process was higher than that of clonal integration, whereas its contribution to soil C availability had the opposite effect. These results further revealed the mechanism of the size of clonal fragment in affecting the rhizosphere processes of stressed ramets, which is critical for the adaptation of P. bissetii to stressed habitats and further bamboo ecosystem N turnover under climate change.
The detrimental effects of delay on the endorsement of misleading details for emotionally salient events
Authors: Shah Datin , Knott Lauren
Published: November 2023

Previous research has shown that the exposure to misleading information continues its detrimental effect on memory over time for negatively arousing events. However, research has also shown that both high-and low-arousing negative events are vulnerable to distortion from misinformation. Therefore, the present study set out to explore the impact of retention interval on memory for negative (arousing and non-arousing) and neutral events in the misinformation paradigm. Participants were presented with a negative high-arousing, a negative low-arousing, and a neutral scene, and exposed to misleading information for central and peripheral aspects of each scene. Recognition memory for scene details was measured 10 min after misinformation exposure and again after one week. We found that, regardless of the type of detail, the effect of misinformation persisted over time for the negative-arousing event but disappeared one week later for the negative low-arousing and neutral events. The results are explained in relation to adaptive function and theories of source monitoring. The findings of this study provide important forensic implications, especially when we consider the arousing nature of crimes.
Evidence of validity and reliability of the environmental action scale in Peruvian university students
Authors: Serpa-Barrientos Antonio , Pérez-Flores Enrique Giovanni , Bellido-Figueroa Gerardo Manuel , Saintila Jacksaint
Published: November 2023

Background

The environmental action scale is used to measure the degree of participation in collective environmental actions and has been shown to have adequate psychometric properties in developed countries. However, there are still no studies that have evaluated its performance in the Peruvian population.

Methods

In this instrumental study, the environmental action scale (EAS) was translated, adapted, and validated. The EAS was administered to 352 university students between 18 and 35 years of age (Mage = 23.37, SD = 2.57) from different cities in Peru. A validity analysis was performed using two sources of evidence: content validity and internal structure, carrying out an exploratory factor analysis (EFA) and a confirmatory factor analysis (CFA).

Results

The structure of the scale has been organized into three oblique factors. The findings confirmed the reliability and validity of the three dimensions of the EAS.

Conclusion

Therefore, this scale is considered a valid option for assessing environmental action.
AI voices reduce cognitive activity? A psychophysiological study of the media effect of AI and human newscasts in Chinese journalism
Authors: Gong Chen
Published: November 2023

Artificial Intelligence (AI) has been widely utilized in automated journalism writing and broadcasting in recent years. However, few systematic studies have been conducted on the differences in brain activation between human and artificial voices in newscasts. This paper aims to investigate the psychophysiological effects of the media in Chinese contexts when different agents (AI or human) broadcast different types (emotional/neutral) of news. Comparing the electrophysiological data of the participants’ EEG while listening to different newscast agents revealed that brain activity responses were greater when listening to a human newscast than to an AI voice newscast. And β bands in left posterior temporal lobe were significantly different, suggesting that participants’ brain were better at processing, comprehending auditory information, and storing working memory when listening to a human reporter than when listening to a voice generated by AI. Moreover, the ERP results and the interaction effect of content valence and agent voice demonstrated that the human voice generated greater cognitive effect, which may reflect participants’ trust in the credibility and fluency of the human voice news. This study demonstrates the importance of further research into cognitive effects of AI journalism.
A new look at an old well-being construct: evaluating the psychometric properties of 9, 5, and 1-item versions of emotional exhaustion metrics
Authors: Penny Caitlin L. , Adair Kathryn C. , Frankel Allan S. , Leonard Michael W. , Proulx Joshua , Mosca Paul J. , Sexton J. Bryan
Published: November 2023

Objective

To compare the relative strengths (psychometric and convergent validity) of four emotional exhaustion (EE) measures: 9- and 5-item scales and two 1-item metrics.

Patients and methods

This was a national cross-sectional survey study of 1409 US physicians in 2013. Psychometric properties were compared using Cronbach’s alpha, Confirmatory Factor Analysis (CFA), Exploratory Factor Analysis (EFA), and Spearman’s Correlations. Convergent validity with subjective happiness (SHS), depression (CES-D10), work-life integration (WLI), and intention to leave current position (ITL) was assessed using Spearman’s Correlations and Fisher’s R-to-Z.

Results

The 5-item EE scale correlated highly with the 9-item scale (Spearman’s rho = 0.828), demonstrated excellent internal reliability (alpha = 0.87), and relative to the 9-item, exhibited superior CFA model fit (RMSEA = 0.082, CFI = 0.986, TLI = 0.972). The 5-item EE scale correlated as highly as the 9-item scale with SHS, CES-D10, and WLI, and significantly stronger than the 9-item scale to ITL. Both 1-item EE metrics had significantly weaker correlation with SHS, CES-D10, WLI, and ITL (Fisher’s R-to-Z; p < 0.05) than the 5- and 9-item EE scales.

Conclusion

The 5-item EE scale was repeatedly found equivalent or superior to the 9-item version across analyses, particularly with respect to the CFA results. As there is no cost to using the briefer 5-item EE scale, the burden on respondents is smaller, and widespread access to administering and interpreting an excellent wellbeing metric is enhanced at a critical time in global wellbeing research. The single item EE metrics exhibited lower convergent validity than the 5- and 9-item scales, but are acceptable for detecting a signal of EE when using a validated EE scale is not feasible. Replication of psychometrics and open-access benchmarking results for use of the 5-tem EE scale further enhance access and utility of this metric.
Higher adverse childhood experiences interference with targeted early intervention to reduce persistence of adult subacute pain: a feasibility open trial
Authors: McSwan Joyce , Stapleton Peta , Panwar Catherine E.
Published: November 2023

Introduction

The feasibility of an Early Subacute Pain Intervention Program was assessed for improving outcomes in patients with subacute pain and exposure to adverse childhood experiences (ACEs) at increased risk of long-term disability.

Methods

Eligible patients were referred by their general practitioner for an open trial of individual case management with group-based education and psychological support sessions and access to allied health services. Measures of pain, disability, and mental health were assessed at baseline, on completion of the 6-month program, and 6 months after completion.

Results

Thirty-nine participants (mean age 51 years, 72% women) completed the program. Pain at baseline was subacute (median duration 9.7 weeks) and of high intensity (median score 8/10), with a mean ACE score of 4.3. After completing the program, participants reported reduced pain severity and interference (~50% reduction), risk of future disability, psychological distress, and number of unhealthy days (~30% reduction) and were all statistically significant (p < 0.001). These gains were maintained at 6-months from the beginning of treatment. Higher ACE scores were associated with greater baseline levels of pain interference, risk of future disability, and psychological distress, and with less improvement in pain interference and psychological distress after completing the program.

Discussion

This program suggested pain-related disability and mental health in patients with subacute pain and ACE exposure may be improved, although with reduced efficacy with higher ACE exposure. There need to be further robust investigation to quantify the value of targeted early intervention programs in primary health care settings to help reduce subacute pain persistence and progression to chronic pain in patients at increased risk of long-term disability.
Brief research report: autistic traits modulate the rapid detection of punishment-associated neutral faces
Authors: Saito Akie , Sato Wataru , Yoshikawa Sakiko
Published: November 2023

Speedy detection of faces with emotional value plays a fundamental role in social interactions. A few previous studies using a visual search paradigm have reported that individuals with high autistic traits (ATs), who are characterized by deficits in social interactions, demonstrated decreased detection performance for emotional facial expressions. However, whether ATs modulate the rapid detection of faces with emotional value remains inconclusive because emotional facial expressions involve salient visual features (i.e., a U-shaped mouth in a happy expression) that can facilitate visual attention. In order to disentangle the effects of visual factors from the rapid detection of emotional faces, we examined the rapid detection of neutral faces associated with emotional value among young adults with varying degrees of ATs in a visual search task. In the experiment, participants performed a learning task wherein neutral faces were paired with monetary reward, monetary punishment, or no monetary outcome, such that the neutral faces acquired positive, negative, or no emotional value, respectively. During the subsequent visual search task, previously learned neutral faces were presented as discrepant faces among newly presented neutral distractor faces, and the participants were asked to detect the discrepant faces. The results demonstrated a significant negative association between the degrees of ATs and an advantage in detecting punishment-associated neutral faces. This indicates the decreased detection of faces with negative value in individuals with higher ATs, which may contribute to their difficulty in making prompt responses in social situations.
The creative behavior of virtual idol fans: a psychological perspective based on MOA theory
Authors: Wang Qingnian , Long Shuyu , Zeng Yanfei , Tang Lan , Wang Yunpei
Published: November 2023

Breakthroughs in digital technology are accelerating the development and commercialization of virtual idols. They are overturning the traditional one-way communication between idols and fans, turning fans into producers and consumers. Therefore, identifying the motivations for fan creation can regulate and guide the creative behavior of fans and turn their creativity into productivity. This paper took “the factors influencing fans’ spontaneous participation in creating virtual idols” as the primary research question, took the Motivation Opportunity Ability (MOA) theory as the research framework, used questionnaires as the primary research method, and combined the relevant research on motivation theory and self-determination theory to explore fans’ creative behavior from the psychological perspective in depth. The empirical tests revealed that in the motivation dimension, interest motivation, achievement motivation, social motivation, and utility motivation all positively influenced fans’ creative behavior; in the opportunity dimension, fans’ perceived cost had a significant negative moderating effect on the influence of interest motivation, social motivation, and utility motivation on fans’ creative behavior; fans’ perceived community atmosphere was substantial. The moderating effect of knowledge and skills on the capability dimension was insignificant. For the virtual idol industry, the future development of the industry could not only focus on IP image creation and content production but also effectively stimulate fans’ creative motivation through the creation of an excellent community atmosphere, the provision of targeted creator services, and the reduction of fans’ perceived costs in the creation process.
Case report: Familial case with autism spectrum and bipolar disorder showing a 20q11.21 microduplication including TM9SF4
Authors: Simoncini Marly , Violi Miriam , Valetto Angelo , Bertini Veronica , Cruz-Sanabria Francy , Massoni Leonardo , Dell’Osso Liliana , Carmassi Claudia
Published: November 2023

Autism spectrum disorder (ASD) is characterized by multifactorial etiology and high heritability but can be challenging to be diagnosed, especially in cases presenting subthreshold symptoms with no cognitive or language impairment, which may not be identified until adulthood but may occur in family members of subjects with ASD. This study explores the possible correlation between a genomic imbalance and clinical phenotypes in a family case of a proband with ASD, with subjects presenting full-blown or subthreshold ASD and/or mood disorders. Clinical assessments were carried out by means of the Structured Clinical Interview for DSM-5 (SCID-5) disorders, Autism Spectrum Quotient (AQ), Autism Diagnostic Interview–Revised (ADI-R), Autism Diagnostic Observation Schedule Module 2 (ADOS-2), and Adult Autism Subthreshold Spectrum (AdAS Spectrum). The genetic evaluation included array comparative genomic hybridization (array-CGH). The proband was diagnosed with ASD and bipolar disorder type I (BD-I), her twin brothers with ASD and intellectual disability (ID), and her father and sister with BD type II (BD-II) and autism traits. The proband, her father, twin brothers, and older sister showed a microduplication of 350 kb in 20q11.21. In contrast, the proband’s mother did not present the microduplication or any mental disorder. This study reports a microduplication that segregates with family members affected by ASD or autistic traits comorbid in some cases with bipolar disorder, and that has never been reported in healthy subjects. Among the genes harbored in this region, the TM9SF4 gene has been recently implicated in risk for ASD.
Improving adult behavioural weight management services for diverse UK Black Caribbean and Black African ethnic groups: a qualitative study of insights from potential service users and service providers
Authors: Maynard Maria J. , Orighoye Oritseweyinmi , Apekey Tanefa , Simpson Ellouise , van Dijk Margie , Atherton Elizabeth , Blackshaw Jamie , Ells Louisa
Published: November 2023

Background

A significantly higher proportion of UK Black ethnic adults live with overweight or obesity, compared to their White British counterparts. The role of obesity in excess infection rates and mortality from COVID-19 has increased the need to understand if weight management interventions are appropriate and effective for Black ethnic groups. There is a paucity of existing research on weight management services in Black populations, and whether anticipated or experienced institutional and interpersonal racism in the healthcare and more widely affects engagement in these services. Understanding the lived experience of target populations and views of service providers delivering programmes is essential for timely service improvement.

Methods

A qualitative study using semi-structured interviews was conducted in June–October 2021 among 18 Black African and Black Caribbean men and women interested in losing weight and 10 weight management service providers.

Results

The results highlighted a positive view of life in the United Kingdom (UK), whether born in the UK or born abroad, but one which was marred by racism. Weight gain was attributed by participants to unhealthy behaviours and the environment, with improving appearance and preventing ill health key motivators for weight loss. Participants relied on self-help to address their overweight, with the role of primary care in weight management contested as a source of support. Anticipated or previously experienced racism in the health care system and more widely, accounted for some of the lack of engagement with services. Participants and service providers agreed on the lack of relevance of existing services to Black populations, including limited culturally tailored resources. Community based, ethnically matched, and flexibly delivered weight management services were suggested as ideal, and could form the basis of a set of recommendations for research and practice.

Conclusion

Cultural tailoring of existing services and new programmes, and cultural competency training are needed. These actions are required within systemic changes, such as interventions to address discrimination. Our qualitative insights form the basis for advancing further work and research to improve existing services to address the weight-related inequality faced by UK Black ethnic groups.
A qualitative study on the clinical safety and user experiences of female condoms for anal intercourse among men who have sex with men in Shanghai, China
Authors: Huang Jia-Lu , Xin Xin , Ma Ming-Jun , Ning Zhen , Xiao Shao-tan , Chen Pan-pan
Published: November 2023

Objective

This qualitative study aimed to understand the clinical safety, efficacy, and receptiveness of using the female condom (FC) during anal intercourse among men who have sex with men (MSM).

Methods

Subjects for this study were recruited from a two-group crossover trial among MSM in Shanghai. The trial consisted of two phases, each including the use of condoms (FC vs. male condom), questionnaires, and in-depth one-on-one interviews. The two phases were separated by a washout period of 4 weeks. The minimum sample size for this study was determined in accordance with the principle of “information saturation.” The qualitative data were organized and analyzed using ATLAS.ti version 7.

Results

A total of 26 participants from the MSM population were recruited for this study, with 10 assuming the insertive role (i.e., “1”), 8 assuming the receptive role (i.e., “0”), and 8 being versatile (i.e., “0.5”). Each participant completed the crossover trial comprising two phases. The cumulative usage of FCs and male condoms (MCs) amounted to 115 and 127 times, respectively. During the reported sexual encounters, no participants reported incidents of condom rupture, slippage, or other malfunctions. A few participants reported experiencing slight chafing pain, primarily put forward by “0” participants. Apart from those reports, no instances of bleeding, swelling, or allergic reactions were reported. The efficiency of FC in disease prevention, the sexual partner’s willingness to use FC, the freshness of FC, and positive sexual experiences were the main reasons for the consistent use of FC for anal sex. Discomfort and pain during sexual activity, the loose design and thick material of FCs, and difficulties in placing FCs were the major obstacles to FC use among MSM. The elements referring to the forehead exhibited varied in importance among “1,”, “0,” and “0.5” participants. Regarding the willingness to use the FC in the future anal intercourse, 61.54% of participants expressed a positive inclination, 23.08% were uncertain, and 15.38% stated that they would not. “A better sense of security during anal sex” was the main factor affecting willingness among “0” participants and “the sexual pleasure that the FC brought” among “1” participants. Improving the design and technology of FCs and increasing the frequency of use and practice might improve the use skills, which will favor the willingness to use FCs among the MSM population.

Conclusion

FCs received positive user feedback from study participants, but distinctions were found in individuals in different sexual roles. Large-scale quantitative studies are needed to evaluate the clinical safety of the FC and its effectiveness in preventing the transmission of STDs during anal intercourse.
The cost-effectiveness of improved brief interventions for tobacco cessation in Thailand
Authors: Palakai Rungrat , Sornpaisarn Bundit , Sawangdee Yothin , Chuanwan Sutthida , Saonuam Pairoj , Katewongsa Piyawat , Rehm Jürgen
Published: November 2023

Background

This study estimated the cost-effectiveness of four strategies enhancing the quality and accessibility of Brief Intervention (BI) service for smoking cessation in Thailand during 2022–2030: (1) current-BI (status quo), (2) the effective-training standard-BI, (3) the current-BI plus the village health volunteers (VHV) mobilization, and (4) the effective-training BI plus VHV mobilization.

Methods

By interviewing five public health officers, nine healthcare professionals aiding these services, and fifteen BI service experts, we explored the status quo situation of the Thai smoking cessation service system, including main activities, their quantity assumptions, and activities’ unit prices needed to operate the current cessation service system. Then, we modeled additional activities needed to implement the other three simulated scenarios. We estimated the costs and impacts of implementing these strategies over a nine-year operating horizon (2022–2030), covering 3 years of service system preparation and 6 years of full implementation. The modeled costs of these four strategies included intervention and program costs. The study focused on current smokers age 15 years or older. The assessed impact parameters encompassed smoking prevalence, deaths averted, and healthy life-years gained. An Incremental Cost-Effectiveness Analysis compared the four simulated strategies was employed. Data analysis was performed using the One Health Tool software, which the World Health Organization developed.

Results

The findings of this investigation reveal that all three intervention strategies exhibited cost-effectiveness compared to the prevailing status quo. Among these strategies, Strategy 2, enhancing BI service quality, emerged as the most efficient and efficacious option. Therefore, the expansion of quality services should be synergistically aligned with augmented training, service delivery optimization, and managerial enhancements.

Conclusion

This approach is particularly poised to enhance accessibility to and the efficacy of smoking cessation interventions across Thailand.
Digital economy: an effective path for promoting residents' health in China
Authors: Zhou Xue , Yan Wen-Ying , Li Xiu-Ting , Li Han , Wu Yi-Zhen , Xu Bao-Chang
Published: November 2023

The primary prerequisite for socioeconomic growth is good health, hence promoting residents' health is a vital objective of public policies. It is yet up for debate whether or not the digital economy (DE), which will be crucial to future economic growth, will eventually result in improvements in residents' health. Utilizing the China Family Panel Studies (CFPS) data in 2020, we explore how the DE affects residents' health. The findings reveal that residents' health is greatly enhanced by the DE. The eastern region sees a more dramatic improvement in residents' health as a result of the DE. Additionally, the DE can improve residents' health through the promotion of regional green development. The study's findings add to our knowledge of how the DE impacts residents' health while also offering recommendations for achieving universal health.
Stereotypical nationality representations in HRI: perspectives from international young adults
Authors: Cumbal Ronald , Axelsson Agnes , Mehta Shivam , Engwall Olov
Published: November 2023

People often form immediate expectations about other people, or groups of people, based on visual appearance and characteristics of their voice and speech. These stereotypes, often inaccurate or overgeneralized, may translate to robots that carry human-like qualities. This study aims to explore if nationality-based preconceptions regarding appearance and accents can be found in people’s perception of a virtual and a physical social robot. In an online survey with 80 subjects evaluating different first-language-influenced accents of English and nationality-influenced human-like faces for a virtual robot, we find that accents, in particular, lead to preconceptions on perceived competence and likeability that correspond to previous findings in social science research. In a physical interaction study with 74 participants, we then studied if the perception of competence and likeability is similar after interacting with a robot portraying one of four different nationality representations from the online survey. We find that preconceptions on national stereotypes that appeared in the online survey vanish or are overshadowed by factors related to general interaction quality. We do, however, find some effects of the robot’s stereotypical alignment with the subject group, with Swedish subjects (the majority group in this study) rating the Swedish-accented robot as less competent than the international group, but, on the other hand, recalling more facts from the Swedish robot’s presentation than the international group does. In an extension in which the physical robot was replaced by a virtual robot interacting in the same scenario online, we further found the same results that preconceptions are of less importance after actual interactions, hence demonstrating that the differences in the ratings of the robot between the online survey and the interaction is not due to the interaction medium. We hence conclude that attitudes towards stereotypical national representations in HRI have a weak effect, at least for the user group included in this study (primarily educated young students in an international setting).
Combinatorics: The Mathematics of Fair Thieves and Sophisticated Forgetters
Authors: Alon Noga
Published: November 2023

Mathematics is the most logical and unbiased scientific field there is. What is true in mathematics today will forever stay true, and mathematical arguments will always clearly indicate which side “wins”. These are some of the characteristics of mathematics that I have liked very much since I was young. In this article, I will try to demonstrate the beauty of mathematics and show you that it appears in many situations in our daily lives—including places we might not expect. Then, I will give you a taste of two studies I conducted in a mathematical field called combinatorics, and I will explain how they are related to everyday problems. One of these problems is how to perform accurate mathematical analyses of large streams of data that we cannot save in a computer’s memory. Finally, I will try to give you an idea of my life as a mathematician—the challenges and difficulties, alongside the immense enjoyment and satisfaction I derive from them. Join me to an extended dive into my work on the wonders of combinatorics.