bluuebunny/crossref_metadata_2025 huggingface dataset:
Work-life balance for transnational skilled workers in Sweden
Authors: Ivana Greti-Iulia
Published: November 2020

In the context of globalisation, increased mobility and transnational travelling, long-distance friendships, romantic partnerships and family ties are becoming more and more common.

Against this backdrop, this article focuses on highly skilled employees coming from Romania to Sweden and how they construct their work-life balance there. It analyses the work-life systems of highly skilled migrants in relation both to their co-present and long-distance bonds and overreliance on work networks of contacts, as well as investigating the relation between a particular work-life balance and highly skilled transnational workers' adoption of serial or circular migration. In doing so, this research asks how the work-life balance of highly skilled migrants can be understood from a life-course standpoint. The originality of this article comes from the interest in the work-life of transnational workers of both genders and of different family configurations, when most research on the topic of work-life balance still focuses almost exclusively on women and tensions between professional demands and traditional family lives.
Microstructuring of 3D movie theater metallic screens to improve radiant intensity homogeneity and reduce crosstalk
Authors: Le Deun Thomas , Stoenescu Daniel , de Bougrenet de la Tocnaye Jean-Louis
Published: November 2020

We present analytical and experimental results of the microstructuring of movie theater metallic screens. Our objective is to maintain the polarization state of reflected light and to control the distribution of light intensity avoiding hotspots. We derive analytical solutions of surface functions with an axial symmetry (kernel) that produces isotropic and Lambertian scattering. Then we model the diffraction that can occur with such kernels, ranging from a few microns to several hundred microns, and we give illustrations when illuminated by laser beams corresponding to future use of laser projectors. Finally, we discuss some of the challenges associated with the tiling of such kernels and their manufacturing.
Multi-diffractive grating for surface plasmon biosensors with direct back-side excitation
Authors: Hageneder Simone , Fossati Stefan , Ferrer Nicolas-Guillermo , Güngörmez Batuhan , Auer Simone K. , Dostalek Jakub
Published: November 2020

A multi-diffractive nanostructure is reported for the resonant excitation of surface plasmons that are cross-coupled through a thin metallic film. It consists of two superimposed periodic corrugations that allow diffraction excitation of surface plasmons on the inner side of a thin metal film and their subsequent phase matching with counterpropagating surface plasmons travelling to the opposite direction on its other side. This interaction leads to establishing of a set of cross-coupled Bragg-scattered surface plasmon modes that exhibit an electromagnetic field localized on both metal film interfaces. The reported structure is attractive for surface plasmon resonance biosensor applications, where direct optical probing can be done through the substrate without the need of optical matching to a high refractive index prism. In addition, it can be prepared by mass production – compatible means with UV-nanoimprint lithography and its biosensing performance characteristics are demonstrated by refractometric and biomolecular affinity binding studies.
Doppler effect as a tool for ultrashort electric field reconstruction
Authors: Béjot P. , Szmygel E. , Dubrouil A. , Billard F. , Lavorel B. , Faucher O. , Hertz E.
Published: November 2020

We present a new, to the best of our knowledge, variant of the spectral-shearing interferometry method for characterizing ultrashort laser pulses. This original approach, called Doppler effect e-field replication (DEER), exploits the rotational Doppler effect for producing frequency shear and provides spectral shearing in the absence of frequency conversion, enabling operation in the ultraviolet spectral range. Evaluation of the DEER–spectral phase interferometry for direct electric field reconstruction setup reveals a phase reconstruction of great reliability. Possible improvements, benefits, and worthwhile prospects of the method are discussed.
Surface tension and viscosity measurement of oscillating droplet using rainbow refractometry
Authors: Lv Qimeng , Wu Yingchun , Li Can , Wu Xuecheng , Chen Linghong , Cen Kefa
Published: November 2020

We extend rainbow refractometry to quantify the oscillations of a droplet in its fundamental mode. The oscillation parameters (frequency and amplitude damping), extracted using the time-resolved rainbow angular shift, are utilized to measure surface tension and viscosity of the liquid. Proof-of-concept experiments on an oscillating droplet stream produced by a monodisperse droplet generator are conducted. Results show that the relative measurement errors of surface tension and viscosity are 1.5% and 8.4% for water and 5.3% and 2.5% for ethanol. This approach provides an alternative mean for characterizing liquid surface properties, e.g., dynamic surface tension and viscosity, especially for liquids with a low Ohnesorge number.
Strong intracellular signal inactivation produces sharper and more robust signaling from cell membrane to nucleus
Authors: Ma Jingwei , Do Myan , Le Gros Mark A. , Peskin Charles S. , Larabell Carolyn A. , Mori Yoichiro , Isaacson Samuel A.
Published: November 2020

For a chemical signal to propagate across a cell, it must navigate a tortuous environment involving a variety of organelle barriers. In this work we study mathematical models for a basic chemical signal, the arrival times at the nuclear membrane of proteins that are activated at the cell membrane and diffuse throughout the cytosol. Organelle surfaces within human B cells are reconstructed from soft X-ray tomographic images, and modeled as reflecting barriers to the molecules’ diffusion. We show that signal inactivation sharpens signals, reducing variability in the arrival time at the nuclear membrane. Inactivation can also compensate for an observed slowdown in signal propagation induced by the presence of organelle barriers, leading to arrival times at the nuclear membrane that are comparable to models in which the cytosol is treated as an open, empty region. In the limit of strong signal inactivation this is achieved by filtering out molecules that traverse non-geodesic paths.
Genotype imputation using the Positional Burrows Wheeler Transform
Authors: Rubinacci Simone , Delaneau Olivier , Marchini Jonathan
Published: November 2020

Genotype imputation is the process of predicting unobserved genotypes in a sample of individuals using a reference panel of haplotypes. In the last 10 years reference panels have increased in size by more than 100 fold. Increasing reference panel size improves accuracy of markers with low minor allele frequencies but poses ever increasing computational challenges for imputation methods. Here we present IMPUTE5, a genotype imputation method that can scale to reference panels with millions of samples. This method continues to refine the observation made in the IMPUTE2 method, that accuracy is optimized via use of a custom subset of haplotypes when imputing each individual. It achieves fast, accurate, and memory-efficient imputation by selecting haplotypes using the Positional Burrows Wheeler Transform (PBWT). By using the PBWT data structure at genotyped markers, IMPUTE5 identifies locally best matching haplotypes and long identical by state segments. The method then uses the selected haplotypes as conditioning states within the IMPUTE model. Using the HRC reference panel, which has ∼65,000 haplotypes, we show that IMPUTE5 is up to 30x faster than MINIMAC4 and up to 3x faster than BEAGLE5.1, and uses less memory than both these methods. Using simulated reference panels we show that IMPUTE5 scales sub-linearly with reference panel size. For example, keeping the number of imputed markers constant, increasing the reference panel size from 10,000 to 1 million haplotypes requires less than twice the computation time. As the reference panel increases in size IMPUTE5 is able to utilize a smaller number of reference haplotypes, thus reducing computational cost.
Taxonomic diversity pattern and composition of fish species in the upper reaches of Ganjiang River, Jiangxi, China
Authors: Shi Zimo , Zhang Jianming , Wu Haijun , Yang Jing , Hu Maolin
Published: November 2020

Maintaining fish diversity is essential for environmental protection. To characterize the fish composition of the tributaries and mainstream in the upper reaches of the Ganjiang River, we identified seventy-five species of 15 families in 14 sampling sites. These data were analyzed using the inclusion index at the taxonomic level (TINCLi), the importance value index (IVI), the taxonomic diversity indices (Δ+ and Λ+), cluster analysis and non-metric multidimensional scaling (nMDS). The results showed that the most common and dominant order was the Cypriniformes, represented most frequently by Hemiculter leucisculus among the sample sites. Most fishes were omnivorous, mountain stream or settled fish that lay sinking or viscid eggs. Most sites showed a trend of more discrete distribution from high latitude to low latitude. According to the taxonomic diversity indices, the fish taxonomic composition in the upper reaches of Ganjiang River is uneven. The Bray-Curtis resemblance matrix and nMDS showed that the habitats of the Ganjiang River were divided into four areas. The results will provide information needed for freshwater fish resource protection in the upper reaches of the Ganjiang River.
Divergent organ-specific isogenic metastatic cell lines identified using multi-omics exhibit differential drug sensitivity
Authors: Winnard Paul T. , Vesuna Farhad , Muthukumar Sankar , Raman Venu
Published: November 2020

Background

Monitoring and treating metastatic progression remains a formidable task due, in part, to an inability to monitor specific differential molecular adaptations that allow the cancer to thrive within different tissue types. Hence, to develop optimal treatment strategies for metastatic disease, an important consideration is the divergence of the metastatic cancer growing in visceral organs from the primary tumor. We had previously reported the establishment of isogenic human metastatic breast cancer cell lines that are representative of the common metastatic sites observed in breast cancer patients.

Methods

Here we have used proteomic, RNAseq, and metabolomic analyses of these isogenic cell lines to systematically identify differences and commonalities in pathway networks and examine the effect on the sensitivity to breast cancer therapeutic agents.

Results

Proteomic analyses indicated that dissemination of cells from the primary tumor sites to visceral organs resulted in cell lines that adapted to growth at each new site by, in part, acquiring protein pathways characteristic of the organ of growth. RNAseq and metabolomics analyses further confirmed the divergences, which resulted in differential efficacies to commonly used FDA approved chemotherapeutic drugs. This model system has provided data that indicates that organ-specific growth of malignant lesions is a selective adaptation and growth process.

Conclusions

The insights provided by these analyses indicate that the rationale of targeted treatment of metastatic disease may benefit from a consideration that the biology of metastases has diverged from the primary tumor biology and using primary tumor traits as the basis for treatment may not be ideal to design treatment strategies.
Cultural variations in global and local attention and eye-movement patterns during the perception of complex visual scenes: Comparison of Czech and Taiwanese university students
Authors: Čeněk Jiří , Tsai Jie-Li , Šašinka Čeněk
Published: November 2020

Previous research on cross-cultural differences in visual attention has been inconclusive. Some studies have suggested the existence of systematic differences in global and local attention and context sensitivity, while others have produced negative or mixed results. The objective in this study was to examine the similarities and differences in holistic and analytic cognitive styles in a sample of Czech and Taiwanese university students. Two cognitive tasks were conducted: a Compound Figures Test and a free-viewing scene perception task which manipulated several focal objects and measured eye-movement patterns. An analysis of the reaction times in the Compound Figures Test showed no clear differences between either sample. An analysis of eye-movement metrics showed certain differences between the samples. While Czechs tended to focus relatively more on the focal objects measured by the number of fixations, the Taiwanese subjects spent more time fixating on the background. The results were consistent for scenes with one or two focal objects. The results of a correlation analysis of both tasks showed that they were unrelated. These results showed certain differences between the samples in visual perception but were not as systematic as the theory of holistic and analytic cognitive styles would suggest. An alternative model of cross-cultural differences in cognition and perception is discussed.
A permissive approach for optimization of L-glutaminase production using wheat bran as supporting substrate and assessment of its cytotoxic potentialities
Authors: Soren Jyoti P. , Halder Suman K. , Mondal Joy , Hor Papan K. , Mohapatra Pradeep K. D. , Mondal Keshab C.
Published: November 2020

Microbial L-glutaminase has considered as one of the most important therapeutic enzymes considering its anticancer or antitumor activity. In this study, one L-glutaminase producing potent fungus was isolated from the coastal soil and identified as Fusarium nelsonii KPJ-2. During parametric optimization, it was noted that wheat bran supported maximum L-glutaminase production than other agro-industrial wastes tested. Solid substrate fermentation was mechanized with optimum pH of 4.0, incubation temperature at 25 °C, inoculums concentration of 2.0% (v/v), substrate concentration of 7.0% (w/v) and moisture of the production media suits at 20.0% (w/v). Statistical optimization using Response Surface Methodology (RSM) was improved the L-glutaminase production by 14.5% (68.93 U/gds) than unoptimized state. The SEM-EDX analysis demonstrated the overgrowth of fungus on wheat bran and utilization of its associated minerals. A comparative cytotoxic effect of the partial purified glutaminase was examined on both cancerous HCT cell and normal Vero cell line. The result clearly demonstrated that L-glutaminase from F. nelsonii KPJ-2 is specifically cytotoxic against cancer cell line with IC50 of 203.95µg/ml, but, non-responsive against normal cell. The newly isolated fungal strain can produce a considerable amount of L-glutaminase utilizing very low-cost substrate and the enzyme have therapeutic value for real life application owing to its anticancer effectiveness.
Caracterização das diferenças no padrão de mobilidade de mulheres e homens em grandes cidades brasileiras
Authors: Macêdo Bianca , Pinto Davi Garcia Lopes , Siqueira Matheus Fontenelle , Lopes André Soares , Loureiro Carlos Felipe Grangeiro
Published: November 2020

Estudos em todo o mundo apontam para a ocorrência de padrões de mobilidade distintos entre mulheres e homens, que são explicados, em grande parte, pela divisão sexual do trabalho. Este esforço de pesquisa objetivou caracterizar essas diferenças para a realidade urbana brasileira. Para isso, inicialmente foram levantadas hipóteses acerca das desigualdades na mobilidade por gênero e sua relação com a divisão sexual do trabalho. Para cada hipótese levantada, indicadores foram definidos e estimados com base nos mais recentes dados de pesquisas OD domiciliares de três capitais brasileiras, representando regiões distintas do país. Os resultados obtidos para cada capital foram então comparados e discutidos, assim como analisada a evolução temporal das desigualdades na mobilidade por gênero em São Paulo, entre 2007 e 2017. Conclui-se que há evidências empíricas para validar a maioria das hipóteses levantadas, mostrando que de fato há diferenças nos padrões de deslocamentos de mulheres e homens no meio urbano brasileiro.
Planejamento de entregas em áreas urbanas considerando recarregamento intermediário, veículos com múltiplos compartimentos e restrição de acesso
Authors: Astoures Henrique Fiorot , Rosa Rodrigo Alvarenga
Published: November 2020

Face ao aumento da demanda por transporte de mercadorias por comércios e residências nos últimos anos e, considerando as restrições de entrada de caminhões de grande porte impostas pelas cidades, faz-se necessário planejar as entregas de maneira diferente. Assim, esse artigo propõe o planejamento da entrega de mercadorias considerando recarregamento intermediário na rota, veículos com múltiplos compartimentos, alocação independente das caixas, período de atendimento e restrições de acesso nos clientes. Para planejar as entregas em áreas urbanas, é proposta uma nova classe de problema denominada Site Dependent Multiple Compartment Vehicle Routing Problem with Intermediate Replenishment Facilities and Time Windows com objetivo de minimizar o custo total do transporte. Foi analisado o problema de uma empresa que está em implantação na cidade de Vitória, ES. Utilizou-se o CPLEX 12.8 para resolver o modelo e os resultados mostraram que a disponibilidade de mais armazéns intermediários é a estratégia mais econômica.
Free Radical Scavenging and In vitro Cytotoxic Activity of Bugnay (Antidesma bunius) Leaves Extract against A549 Human Lung Adenocarcinoma and HCT-116 Human Colorectal Cancer Cell Lines
Authors: Geronimo Arnold Joseph O. , Bancual Mari Erika Joi F. , Ko Karl Anthony L. , Soliba Lycon Marie L. , Ildefonso Jeric John C. , Soriano Angelica Mae B. , Tagalog Alta Christine Marie M. , Acosta Nikolai E. , Ang Vincent S. , Apigo Mariebon A. , Buenconsejo Dana Grace S. , Chan Joanna Kaitlin G. , Gresh Cassandra B. , Santos Crisel B. , Buñag Leo Emmanuel R. , Domantay John Anthony A.
Published: November 2020

Cancer is one of the significant causes of mortality worldwide. Studies on antineoplastic drugs focused on natural products have revealed several mechanisms to inhibit cancer cells. Bugnay (Antidesma bunius) leaves showed potentials due to its activity observed against brine shrimp and breast cancer cells. However, there is still limited knowledge about its activity against other human cancer cells. This study focused on determining the phytochemical compounds in A. bunius leaves extract, the free radical scavenging activity of the extract using the Diphenylpicrylhydrazyl (DPPH) method, and in vitro cytotoxic activity against two cancer cell lines, namely HCT-116 human colorectal and A549 human lung adenocarcinoma cancer cell lines by using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The phytochemicals identified were unsaturated lactones, flavonoids, phenolics, diterpenes, saponins, tannins, carbohydrates, and reducing sugars. The extract showed significant free radical scavenging activity and a direct correlation of activity with concentration levels. It also exhibited cytotoxic activity against HCT-116 human colorectal and A549 human lung adenocarcinoma. Hence, A. bunius leaves have the potential to be a source of antioxidant and antineoplastic compounds. This warrant further isolation of the compounds for chemotherapeutic purposes.Keywords: Antidesma bunius, Bugnay, Cancer, Cytotoxicity, Radical
The Right to Inclusive Education in the Light of the Convention on the Rights of Persons with Disabilities
Authors: Sidi Diallo Boubacar
Published: November 2020

This article examines the rights of persons with disabilities in the field of inclusive education based on fundamental human rights outlined in the Convention on the Rights of Persons with Disabilities. Inclusive education is essential to achieve universal respect for the right to education, including persons with disabilities. Only inclusive education systems can offer persons with disabilities both quality education and the opportunity to improve their social situation. Inclusive education is not just about placing students with disabilities in mainstream educational institutions; it also means making them feel welcome, respected and valued. The values that underlie the concept of inclusive education reinforce the capacity of everyone to achieve their goals and to conceive of diversity as a source of enrichment. Students with disabilities need appropriate support to participate in the education system on an equal basis with other students. Ordinary educational institutions must provide students with disabilities with a learning environment that maximizes academic progress and socialization.
Regulatory Elements Inserted into AAVs Confer Preferential Activity in Cortical Interneurons
Authors: Rubin Anna N. , Malik Ruchi , Cho Kathleen K. A. , Lim Kenneth J. , Lindtner Susan , Robinson Schwartz Sarah E. , Vogt Daniel , Sohal Vikaas S. , Rubenstein John L. R.
Published: November 2020

Cortical interneuron (CIN) dysfunction is thought to play a major role in neuropsychiatric conditions like epilepsy, schizophrenia and autism. It is therefore essential to understand how the development, physiology, and functions of CINs influence cortical circuit activity and behavior in model organisms such as mice and primates. While transgenic driver lines are powerful tools for studying CINs in mice, this technology is limited in other species. An alternative approach is to use viral vectors such as AAV, which can be used in multiple species including primates and also have potential for therapeutic use in humans. Thus, we sought to discover gene regulatory enhancer elements (REs) that can be used in viral vectors to drive expression in specific cell types. The present study describes the systematic genome-wide identification of putative REs (pREs) that are preferentially active in immature CINs by histone modification chromatin immunoprecipitation and sequencing (ChIP-seq). We evaluated two novel pREs in AAV vectors, alongside the well-establishedDlx I12benhancer, and found that they drove CIN-specific reporter expression in adult mice. We also showed that the identifiedArl4dpRE could drive sufficient expression of channelrhodopsin for optogenetic rescue of behavioral deficits in theDlx5/6+/−mouse model of fast-spiking CIN dysfunction.
Metaplasticity in the Ventral Pallidum as a Potential Marker for the Propensity to Gain Weight in Chronic High-Calorie Diet
Authors: Gendelis Shani , Inbar Dorrit , Inbar Kineret , Mesner Shanee , Kupchik Yonatan M.
Published: November 2020

A major driver of obesity is the increasing palatability of processed foods. Although reward circuits promote the consumption of palatable food, their involvement in obesity remains unclear. The ventral pallidum (VP) is a key hub in the reward system that encodes the hedonic aspects of palatable food consumption and participates in various proposed feeding circuits. However, there is still no evidence for its involvement in developing diet-induced obesity. Here we examine, using male C57BL6/J mice and patch-clamp electrophysiology, how chronic high-fat high-sugar (HFHS) diet changes the physiology of the VP and whether mice that gain the most weight differ in their VP physiology from others. We found that 10–12 weeks of HFHS diet hyperpolarized and decreased the firing rate of VP neurons without a major change in synaptic inhibitory input. Within the HFHS group, the top 33% weight gainers (WGs) had a more hyperpolarized VP with longer latency to fire action potentials on depolarization compared with bottom 33% of weight gainers (i.e., non-weight gainers). WGs also showed synaptic potentiation of inhibitory inputs both at the millisecond and minute ranges. Moreover, we found that the tendency to potentiate the inhibitory inputs to the VP might exist in overeating mice even before exposure to HFHS, thus making it a potential property of being an overeater. These data point to the VP as a critical player in obesity and suggest that hyperpolarized membrane potential of, and potentiated inhibitory inputs to, VP neurons may play a significant role in promoting the overeating of palatable food.

SIGNIFICANCE STATEMENTIn modern world, where highly palatable food is readily available, overeating is often driven by motivational, rather than metabolic, needs. It is thus conceivable that reward circuits differ between obese and normal-weight individuals. But is such difference, if it exists, innate or does it develop with overeating? Here we reveal synaptic properties in the ventral pallidum, a central hub of reward circuits, that differ between mice that gain the most and the least weight when given unlimited access to highly palatable food. We show that these synaptic differences also exist without exposure to palatable food, potentially making them innate properties that render some more susceptible than others to overeat. Thus, the propensity to overeat may have a strong innate component embedded in reward circuits.
Factores que influyen en la motivación del deportista
Authors: Nope Diana Carolina , Petro Jorge Luis , Bonilla Diego A.
Published: November 2020

En la actualidad, la motivación es uno de los campos de mayor interés en la práctica deportiva de alto rendimiento; de hecho, han surgido nuevos planteamientos y, al mismo tiempo, interrogantes acerca de las razones que llevan al deportista bien sea al incremento o bien al descenso de su rendimiento. El objetivo de este artículo es resumir diferentes factores que influyen sobre la motivación de los deportistas, para lo cual se llevó a cabo una revisión narrativa al analizar la literatura disponible en las bases de datos PubMed, Scielo y Dialnet que abordan este tema. Con un índice Price de 54 %, los artículos revisados muestran que el estado de ánimo del deportista es de gran importancia, al considerar la influencia que este tiene sobre el desarrollo del autocontrol y la toma de decisiones, elementos fundamentales para la consecución de objetivos propuestos y el éxito deportivo. Este trabajo resalta la influencia que pueden tener diferentes factores sobre la motivación/desmotivación y el cumplimiento de los objetivos físico-deportivos, como los vínculos socioafectivos, el liderazgo y la cohesión del grupo, así como la participación del entrenador, la competitividad, el constructo del ego, el efecto de la ansiedad y el temor a la evaluación negativa.
Remarks on an Encyclopaedic Article on Tǝgre
Authors: Idris Saleh M. , Voigt Rainer
Published: November 2020

Review Article
Mussie Tesfagiorgis G., Eritrea and Paulos Milkias, Ethiopia
Authors: Krzyzanowska Magdalena
Published: November 2020

Review
Denis Nosnitsin, ed., Ecclesiastic Landscape of North Ethiopia: Proceedings of the International Workshop Ecclesiastic Landscape of North Ethiopia: History, Change and Cultural Heritage. Hamburg, July 15–16, 2011
Authors: Assefa Daniel
Published: November 2020

Review
Curt Niccum, The Bible in Ethiopia: The Book of Acts
Authors: Knibb Michael
Published: November 2020

Review
In memoriam Sven Rubenson (1921–2013)
Authors: Gebremedhin Ezra
Published: November 2020

Obituary
Toxic Epidermal Necrolysis (TEN) in an elderly with comorbidities: a case report
Authors: Sudarsa Prima Sanjiwani Saraswati , Puspawati Ni Made Dwi , Purnama Ni Ketut Rai , Sanjaya I Gusti Putu Hendra , Hamid Agus Roy Rusly Hariantana
Published: November 2020

Background: In Toxic Epidermal Necrolysis (TEN), age has been reported to be not only a risk factor but also associated with increased mortality. The presence of underlying illness and comorbidities also increased the burden of TEN in elderly patients.Case: A-70-years old male patient was consulted with a history of pulmonary tuberculosis and skin detachment. Symptoms started since four weeks before admitted to the hospital with redness in the face and extremities that spread to the chest and back accompanied by fever and malaise. The patient also complained of a wound in the lips and genitalia. Physical examination found multiple erosion, geographical shape, varied in size with positive nickolsky sign. The detachment covered 40% of the body surface area. From the laboratory, a result found a decrease in hemoglobin, blood glucose, albumin, and potassium. The patient was diagnosed with TEN, treated in the burn care unit, given supportive care and intravenous dexamethasone 10 mg every 8 hours, and then tapered off. The mortality rate from SCORTEN count was 12,1%.Discussion: The incidence and mortality of TEN were higher in the elderly than among younger adults. Supportive care was the key feature of management with various adjunctive therapy, including systemic corticosteroids, intravenous immunoglobulin, and other immunosuppressant agents. Giving more comorbidities, more observation, and a multidisciplinary approach for TEN in elderly patients might be needed.Conclusion: In the elderly, the risk and mortality of TEN were even higher, and the presence of comorbidities require more observation and supportive care.
The correlation of Neutrophil-Lymphocyte Ratio (NLR) and Platelet-Lymphocyte Ratio compared to D-dimer as a diagnostic test in Deep Vein Thrombosis (DVT)
Authors: Sujana Kadek Yuda , Semadi I Nyoman , Mahadewa Tjokorda Gde Bagus
Published: November 2020

Background:Â Deep vein thrombosis (DVT) is a blood clot that occurs in the inner veins caused by heart disease, infection, cancer, and prolonged immobilization of the limbs. Neutrophil-Lymphocyte Ratio (NLR) and Platelet Lymphocyte Ratio (PLR) have been known as a marker of the primary hemostasis process related to the inflammatory pathway. This study aims to evaluate the correlation of Neutrophil-Lymphocyte Ratio (NLR) and Platelet-Lymphocyte Ratio compared to D-dimer as a diagnostic test in Deep Vein Thrombosis (DVT)Methods:Â A cross-sectional approach has been conducted in this diagnostic study at the Sanglah General Hospital by using secondary data from medical records during July 2018-2019. The study sample consisted of 49 patients with suspected DVT originating from a population who met the inclusion and exclusion criteria. The variables assessed in this study were NLR, PLR, and D-Dimer. Data collection and data analysis were performed by SPSS version 17 for Windows.Results:Â The average age of respondents was 53.10Â±13.40 years old. Most of the respondents were male (59.20%), having edema in the lower extremity (61.20%), left unilateral laterality (53.10%), and D-Dimer levels â‰¥ 0,5 Âµg/ml (76.1%). There was a statistically significant relationship between the average value of NLR (9,07Â±4,2) and PLR (183,55Â±66,52) with the occurrence of DVT (P<0.05). The Area Under Curve (AUC) of ROC Analysis was 94.40% (Cut-off: 8.20; p<0.050) in NLR and 92.10% (Cut-off: 159.66) in PLR to the D-Dimer on the incidence of DVT. There was a significant moderate positive correlation between NLR and PLR combination on DVT incidences (r=0.532; p=0.001).Conclusion:Â  NLR and PLR can be used as an alternative to DVT diagnostic tools due to high sensitivity and specificity, easy to use, inexpensive, simple, and widely available in Indonesia.
Position paper from the Indonesian Society of Thrombosis and Hemostasis (InaSTH), Semarang chapter: Management of coagulopathy in COVID-19
Authors: Pangarsa Eko Adhi , Setiawan Budi , Santosa Damai , Naibaho Ridho M. , Rizky Daniel , - Suyono , Tobing Mika L. , Suharti Catharina
Published: November 2020

A newly emerging pandemic of coronavirus disease 2019 caused by severe acute respiratory coronavirus 2 is responsible for significant morbidity and mortality worldwide. The ongoing substantial research endeavor to comprehend its associated coagulopathy requires proportional progress on guidance establishment. Current review of evidence and statements on management of coagulopathy and thrombotic complications related to this novel disease is expected to be a precursory formulation for prospective guideline development.
A network meta-analysis on comparative efficacy and tolerability of on-demand therapy for premature ejaculation
Authors: Yogiswara Niwanda , Azmi Yusuf , Azmi Yufi Aulia
Published: November 2020

Introduction: The use of pharmacotherapy as a first-line treatment for premature ejaculation (PE) is recommended by EAU guidelines. However, no study had analyzed multiple treatment comparisons among available on-demand therapy. Therefore, we aimed to perform a network meta-analysis (NMA) to characterize the comparative efficacy and tolerability of on-demand therapy for PE.Methods: We systematically searched randomized controlled trials (RCTs) in several databases at any period up to November 2019. NMA was performed to estimate efficacy and tolerability outcomes using intravaginal ejaculation latency time (IELT) and overall adverse effects (AEs), respectively. We ranked each outcome using the surface under the cumulative ranking curve (SUCRA) and presented the two outcomes as a clustered ranking plot.Results: A total of 19 RCTs comprising 5950 patients were included in this NMA. All active treatments showed significant improvement compared to placebo. Among the available on-demand treatment, the combination of SSRI plus PDE5i showed the highest efficacy (MD: 3.06; 95%CI 1.84-4.29) followed by tramadol 100 mg and vardenafil 10 mg (MD 2.9, 95%CI 1.63-4.16; MD 2.36, 95%CI 1.2-3.52; respectively). Based on the SUCRA, the combination of SSRI plus PDE5i had the highest score (91.7%) in efficacy, while dapoxetine 30 mg had the highest score (73.3%) in terms of tolerability.Conclusion: The combination of SSRI plus PDE5i was the treatment of choice for individuals who prioritize efficacy. For those who prioritize tolerability, dapoxetine 30 mg and vardenafil 10 mg became alternative treatments. Various on-demand therapy options require careful discussion with patient expectations of treatment effects.
Being a Higher Education Teacher: Living in the Professional Space and Creating the Professional Body
Authors: Žydžiūnaitė Vilma , Daugėla Marius
Published: November 2020

Phenomenological research relies on the position that teaching in higher education should not be considered a duty that just needs to be carried out by the higher education teacher. It is a crucial part of academia, and it is essential that the higher education teacher portrays it as such. The research examined the patterns of the higher education teacher’s experiences that are meaningful with regard to the professional body and professional space within higher education.
Features of in-hospital clinical course of pulmonary embolism in patients of different age groups
Authors: Shmidt E. A. , Berns S. A. , Neeshpapa A. G. , Talyzin P. A. , Zhidkova I. I. , Mamchur I. N. , Potapenko A. A. , Chukalenko D. A. , Barbarash O. L.
Published: November 2020

Aim.To study the clinical course and management of patients with pulmonary embolism (PE) of various age groups hospitalized in a cardiology hospital.

Material and methods.This prospective single-center study in the period from 2016 to 2018 included 154 patients with PE verified by computed tomography. Statistical processing was conducted using the MedCalcVersion 16.2.1 software package (Softwa, Belgium).

Results.In all groups, female patients dominated, but the highest number of women (70,7%) belonged to the group of senile patients, while in the group <60 years, only half of patients with PE were women. Comorbid cardiovascular disease and deep vein thrombosis was diagnosed in eldest patients significantly more often than in those <60 years of age. The highest prevalence of cancer and recurrent PE were identified in the group of elderly patients. Thrombolytic therapy was performed most often in patients 60-75 years old, since these patients had a high risk of 30-day mortality according to Pulmonary Embolism Severity Index, but did not have severe comorbidities, as patients older than 75 years. An increase of right atrium size was found in the group of elderly and senile patients in comparison with patients <60 years. The highest pulmonary artery systolic and diastolic pressure was observed in the patients older than 75 years.

Conclusion.In the Kemerovo Oblast, PE most often develops in patients aged 60-75 years and is characterized by a more severe clinical course compared with patients younger than 60 years. Patients over the 60 years of age have severe cardiovascular comorbidity status, atrial fibrillation/flutter and recurrent PE. Surgical treatment for senile patients is limited due to the high risk of postoperative complications, which specifies high mortality. Patients <60 years of age are a third of all patients hospitalized with PE. They have a low risk of mortality, but have an unfavorable course of the hospital period.
Progressive multifaceted approach to the management of geriatric patients with cardiac arrhythmias
Authors: Ilnitski A. N. , Prashchayeu K. I. , Korshun E. I. , Kravchenko E. S. , Pokachalova M. A.
Published: November 2020

Aim. To develop a progressive multifaceted approach to the management of geriatric patients with cardiac arrhythmias.

Material and methods. The study was carried out in 2 stages. The study sample consisted of 262 elderly and senile people (mean age, 69,5±1,1 years). There 145 elderly (mean age, 68,4±1,2 years) and 117 senile patients (mean age 74,4±1,3 years). We analyzed medications used for six months in geriatric patients with arrhytmias and senile asthenia (SA) and without it. The combined strategy of management of geriatric patients with arrhytmias and SA was tested.

Results. SA is most common in geriatric patients who are taking drugs such as class I a, b, c antiarrhythmics, class V antiarrhythmics (cardiac glycosides), diuretics (torasemide, furosemide), and statins. This indicates the need to avoid polypharmacy and to adjust the treatment of geriatric patients with cardiac arrhythmias in accordance with Beers criteria. Presented study revealed that in patients with SA, the total antioxidant activity is reduced, which indicates the need to restore antioxidant defence to such patients. A combined strategy has been developed for the management of geriatric patients with cardiac arrhytmias and SA.

Conclusion. The combined strategy of managing older patients with arrhytmias and SA helped to improve the geriatric status, prevent SA, and increase antioxidant defence. A significant improvement in the quality of life was noted, in particular, in relation to the mental and psychological well-being.
Help2care: ehealth strategies for self care of users and caregivers based on Nightingale’s work
Authors: Querido Ana Isabel Fernandes , Laranjeira Carlos António , Dixe Maria dos Anjos Coelho Rodrigues
Published: November 2020

ABSTRACT Objective: To report the experience of design and implementation of the Help2Care (an ehealth program that aims to support informal caregivers of dependent people); and to identify its structure and functionality. Methods: This is a Portuguese experience report about Help2Care, a practice-based action research project carried out between 2017 and 2019, having as a guiding axis Florence Nightingale’s concepts about the relevance of the home-care environment. Results: The Help2Care program revealed itself to be a valuable support tool for providing better healthcare learning, counselling, and assistance of the informal caregivers of dependent people. Different ehealth strategies were used to empower caregivers in self-care in order to have a safe transition between contexts of care at the time of patient discharge. Conclusion: Help2Care allows to inspire other ways of providing care, as well as a reduction in the readmission rate in health organizations for patients who reveal poor care support in home environments.
Design de uma tecnologia mHealth para escores de estratificação de risco cardiovascular apoiado no Letramento em Saúde
Authors: Galeno Daniele Souto , Moreira Thereza Maria Magalhães , Vergara Clarice Maria Araújo Chagas , Sampaio Helena Alves de Carvalho , Vasconcelos Filho José Eurico de
Published: November 2020

RESUMO Objetivou-se desenvolver um protótipo de design de baixa e alta fidelidade à luz do Letramento em Saúde e contribuir com o profissional de saúde para a escolha do escore de risco cardiovascular mais adequado para cada indivíduo. Estudo metodológico em que se utilizou a metodologia do processo de design de interação participativo centrado no usuário, com contribuições de uma equipe interdisciplinar composta por nutricionista, enfermeira e designer. Contribui-se para a concepção do design de dez telas de baixa fidelidade e de dez telas de alta fidelidade, apoiando-se no checklist, com recomendações para a construção de tecnologias em saúde, considerando-se aspectos fundamentais do Letramento em Saúde. Buscou-se, nos protótipos de baixa e alta fidelidade, desenvolver um layout interativo e agradável para facilitar a utilização pelos profissionais de saúde.
Processos de encaminhamento a serviços especializados em cardiologia e endocrinologia pela Atenção Primária à Saúde
Authors: Bernardino Junior Sérgio Vieira , Medeiros Cássia Regina Gotler , Souza Camila Furtado de , Kich Jordana , Alves Alessandro Menna , Castro Luís César de
Published: November 2020

RESUMO Este estudo objetivou analisar encaminhamentos de pessoas a serviços de cardiologia e endocrinologia pelos médicos da Atenção Primária à Saúde (APS) de um município do Rio Grande do Sul. Estudo transversal com questionários a 25 médicos da APS, 2 cardiologistas, 2 endocrinologistas e 1 médico regulador. A análise estatística foi realizada no SPSS, sendo as variáveis contínuas apresentadas como média ou mediana; e as variáveis categóricas, como frequência absoluta e relativa. Entre os médicos da APS, 96% conhecem, 84% utilizam protocolos de encaminhamento e 92% encaminham os pacientes principalmente para manejo de doenças complicadas que necessitam de avaliação do especialista. Entre os especialistas, 50% conhecem os protocolos, e todos apontam que o principal motivo de encaminhamentos para eles ocorre devido a condições crônicas prevalentes mal controladas na APS, sendo considerados pelos endocrinologistas como mal indicados. O médico regulador avalia que a maioria dos documentos de encaminhamento é incompleta e não permite verificar a gravidade do problema. Conclui-se que os protocolos de encaminhamento não estão sendo utilizados de forma a otimizar os fluxos dos usuários na rede de atenção à saúde, indicando a necessidade de revisão de processos de trabalho, capacitação dos profissionais e articulação entre APS, regulação e Atenção Especializada.
Estrutura dos serviços de saúde bucal ofertados na Atenção Básica no Brasil: diferenças regionais
Authors: Gonçalves Ana Júlia Gizzi , Pereira Pedro Henrique Stremel , Monteiro Vitória , Silva Junior Manoelito Ferreira , Baldani Márcia Helena
Published: November 2020

RESUMO Teve-se por objetivo analisar as condições de acessibilidade, estrutura e oferta de serviços odontológicos de Unidades Básicas de Saúde com Equipe de Saúde Bucal e compará-los entre as regiões geográficas brasileiras. O estudo quantitativo, analítico e transversal utilizou dados secundários referentes aos Módulo I, V e VI da Avaliação Externa do 2º Ciclo do Programa Nacional de Melhoria do Acesso e da Qualidade da Atenção Básica (PMAQ-AB) (2013-2014). A análise descritiva foi realizada por frequências absolutas (n) e relativas (%), e houve comparação entre regiões brasileiras pelo teste qui-quadrado com uso do Teste Z ajustado pelo método Bonferroni (p<0,05). A amostra foi constituída por 24.056 Unidades Básicas de Saúde, nas quais atuavam 29.778 Equipes de Atenção Básica; destas, 16.203 (67,3%) possuíam serviços odontológicos e abrigavam 18.119 Equipes de Saúde Bucal. De maneira geral, as Unidades Básicas de Saúde apresentavam boa estrutura física, porém, baixa acessibilidade para pessoas com deficiência. Os consultórios odontológicos apresentavam estrutura física adequada e equipamentos, instrumentos e insumos odontológicos suficientes. No entanto, exibiam alta proporção na oferta de serviço mutiladores em comparação a procedimentos que evitariam as extrações dentárias, e baixa oferta de referência especializada. Além disso, houve evidenciadas desigualdades regionais, favoráveis às regiões Sul e Sudeste.
A judicialização de demandas odontológicas e o direito à saúde
Authors: Freitas Beatriz Cristina de , Queluz Dagmar de Paula
Published: November 2020

RESUMO O arcabouço jurídico-legal que estruturou o Sistema Único de Saúde influenciou significativamente a evolução da saúde bucal coletiva, no entanto, seu acesso ainda constitui um dos principais desafios da gestão dos sistemas de saúde. À luz dos direitos humanos, o direito à saúde bucal é um direito indissociável da saúde geral. Objetivou-se analisar a judicialização de demandas odontológicas fundamentadas no direito à saúde previsto na Constituição Federal de 1988. Trata-se de um estudo exploratório, descritivo, realizado em base de dados secundários, obtidos nos acórdãos de segunda instância do Tribunal de Justiça de São Paulo, de janeiro de 2016 a abril de 2019. Os resultados foram categorizados e analisados por estatística descritiva. As ações judiciais relativas à odontologia buscam, principalmente: indenizações por danos morais e materiais – 336 acórdãos (65%); indenização pela má qualidade da prestação de serviços odontológicos – 114 acórdãos (22%); e negativa de cobertura de procedimento e/ou materiais, por planos de saúde – 63 acórdãos (13%). As ações por erro odontológico aumentaram 305%, passando de 22 acórdãos, em 2016, para 99, em 2018. Conclui-se que as demandas judiciais referentes à odontologia estão mais voltadas às indenizações materiais e morais da prestação de serviços do que ao acesso e à efetivação de direitos constitucionais à saúde bucal.
Malformações congênitas e uso de agrotóxicos no município de Giruá, RS
Authors: Ferreira Luis Fernando , Costa Angélica Reolon da , Ceolin Silvana
Published: November 2020

RESUMO O objetivo deste estudo foi relacionar o uso de agrotóxicos com a ocorrência de malformações congênitas no município de Giruá (RS), bem como determinar os fatores de risco associados. A pesquisa é de abordagem quantitativa, do tipo descritivo-exploratória, realizada durante o primeiro semestre de 2019. O estudo foi conduzido em duas etapas: (a) associação da ocorrência de malformações com o uso de agrotóxicos, que foi calculada por meio dos Odds Ratios, sendo o Intervalo de Confiança (IC) adotado para as amostras de 95%; e (b) determinação dos fatores de risco associados, em que foi realizada uma entrevista com agricultores residentes no município. Percebe-se que as taxas de malformações congênitas do município de Giruá são superiores à média do estado para o mesmo período. Há probabilidade de que a ocorrência de malformações no município esteja associada ao uso de agrotóxicos, pois todos os valores dos Odds Ratios foram maiores que um. Os fatores de risco identificados foram baixa escolaridade, classe toxicológica e princípios ativos, uso inadequado de Equipamentos de Proteção Individual (EPIs), número de pessoas com diagnóstico de intoxicação ou que relataram algum sinal ou sintoma associado e armazenamento dos produtos.