bluuebunny/crossref_metadata_2025 huggingface dataset:
Conhecimentos pedagógicos na formação de professores: uma análise do manual “Pedagogia e Prática Docente” (2012)
Authors: Hegeto Léia de Cassia Fernandes , Reis Tiago Cordeiro dos
Published: October 2021

Este artigo tem como objetivo analisar os conhecimentos pedagógicos presentes na formação de professores a partir da análise do manual “Pedagogia e Prática Docente”, da autora Maria Amélia R. S. Franco (2012). Os manuais são produtos e produtores de conhecimentos e práticas escolares (BUFREM; SCHMIDT; GARCIA, 2006), sendo também construtores de identidades pessoais e profissionais docentes. A pesquisa qualitativa teve como fundamento a análise documental e a análise de conteúdo (BARDIN, 2011) para revelar os conhecimentos abordados no manual, o qual faz parte da Coleção Docência em Formação/Série Saberes Pedagógicos, da Editora Cortez. Foram selecionadas as seguintes categorias de análise: temáticas e encaminhamento metodológico presentes no livro. Foram analisadas as temáticas: Pedagogia, Didática, Práticas Educativas, Práticas Pedagógicas, Práticas Docentes, Subjetividade Pedagógica e Dialogicidade; e a pesquisa-ação como encaminhamento metodológico. Os resultados revelam que o livro analisado trata sobre os conhecimentos mobilizados no ato de ensinar e os desafios da Pedagogia e Prática Docente, contribuindo, assim, para a formação de professores. O livro propõe uma metodologia de pesquisa pedagogicamente fundamentada para uso dos docentes nas práticas escolares coletivas.
Educação para a sustentabilidade: entre a vida na escola e a escola da vida
Authors: Vieira Ricardo , Vieira Ana Maria , Marques José Carlos
Published: October 2021

Neste texto, apresentamos alguns dados de uma investigação em curso cujo objetivo principal passa por entender as perceções e práticas que pessoas de várias faixas etárias possuem relativamente a questões de sustentabilidade. Desenvolvemos, inicialmente, uma abordagem teórica sobre a sustentabilidade no âmbito dos Objetivos de Desenvolvimento Sustentável (ODS), das Nações Unidas (CONSELHO EMPRESARIAL PARA O DESENVOLVIMENTO SUSTENTÁVEL [BCSD], 2021). Em termos empíricos, entrevistámos quatro sujeitos com as seguintes idades: 15, 22, 61 e 70 anos. Posteriormente à transcrição das entrevistas, fizemos uma análise comparativa das vozes captadas a propósito da importância que atribuem às práticas de sustentabilidade. Tentamos, assim, perceber de que forma a idade e o contexto sociocultural dessas pessoas influenciam as práticas e perceções que elas possuem sobre o tema da sustentabilidade.
HUBUNGAN KONSUMSI SUPLEMEN DENGAN KEBUGARAN JASMANI PADA LAKI-LAKI DEWASA MEMBER TIVOLI FITNESS CENTER DI SIDOARJO
Authors: Afrindo Fajar , Adriani Merryana
Published: October 2021

Physical fitness is the basic capital of a person to perform physical activities efficiently in a long time without fatigue with adequate rest. Good physical fitness can be very influential on the work activities of respondents, and it is also very important for human life. This study aims to analyze the relationship between consuming supplements and nutritional status on the members of Tivoli fitness center in Sidoarjo. The type of the study used in this study was a quantitative approach with Cross Sectional study. This study employed quantitative approach with cross sectional study where each of the respondents was observed or interviewed for once, and dependent and independent variables were observed or interviewed at the same time or following on observation time status. Further, this study applied simple random sampling with sample list of male member respondents in Tivoli fitness center. Variables in this study were independent variables consisting of respondent characteristic, level of knowledge and consumption pattern, and a dependent variable that was physical fitness. Data analysis was done by using statistic test. The results of this study showed that respondents who consumed more supplementshad higher fitness level in which they felt fitter compared to the respondents who did not consume supplements. The result of chi square statistic test from fisher's exact test obtained p value of 0.716. The p value is > 0.05. It can be concluded from the study that consumption of supplements showed no statistically significant relationship with the physical fitness ofthe members of Tivoli fitness center in Sidoarjo.
HUBUNGAN SUHU DAN KELEMBAPAN DENGAN TINGKAT DEHIDRASI PADA PEKERJA PENGASAPAN IKAN
Authors: Ningsih Nensi Kristin
Published: October 2021

Dehydration is a condition when body loses or lacks liquid or water. Dehydration can occur due to an internal factor such as person’s characteristics, and external factors such as the physical condition of environment, and environmental sanitation. An example of a person having the risk of dehydration is smoked fish workers because they are exposed to heat form burning dry coconut shells. The purpose of this study was to discover the correlation between worker characteristics, the physical condition of environment as well as environmental sanitation, and dehydration level. This study used cross sectional design with 19 respondents, and samples were taken using simple random sampling technique. The study took place at RW 02 Kelurahan Kenjeran, Kecamatan Bulak, Surabaya starting from February 2018 until finished. Data were analyzed using cross tabulation, and statistic tests which were chi square and Kolmogorov smirnov with 95% confidence level. Data were collected by measurement, interview, observation, and examination. The results showed that there was correlation between the physical condition of environment which included temperature (p=0,003<0,05) and humidity (p=0,001<0,05). The conclusion of this study was that the physical condition of environment including temperature and humidity had an important role to the dehydration level of the smoked fish workers.
HUBUNGAN PERSEPSI RISIKO DENGAN KEINGINAN SISWA DALAM MENJAGA HIGIENE MENSTRUASI DI SEKOLAH DASAR KAMONING SAMPANG
Authors: Badriyah Nurul Lailatul , Nurmala Ira
Published: October 2021

Maintaining menstrual hygiene is essential to avoid vulvar pruritus, irritation, swelling, vaginal secretions, reproductive tract infections, urinary tract infections, uterine cancer, etc. Sampang is the region with the highest maternal mortality rate in Madura, but recently, maternal mortality rate in Sampang continues to decline. One of the causes of maternal death is due to the lack of reproductive hygiene maintenance during menstruation, so that mothers are at risk of uterine cancer. The present study aimed to analyze the relationship between risk perception and female students’ desire in SDN Kamoning in maintaining menstrual hygiene. It was an observational analytic research using cross sectional research design. This study employed HAPA theory. Health Action Process Approach (HAPA) is a concept approach to change one's behavior by strengthening intention to become action. The variable of risk in HAPA theory can influence individual perception early in the motivation phase. The samples of the study were 32 people, and they were taken by total sampling because the number of samples was very small. Data were collected through questionnaire, and they were analyzed by using spearman correlation. The results showed that there was correlation between perception of risk (p = 0,000) and intention to maintain menstrual hygiene. Relationships obtained were not strong because some respondents did not agree with the statements in the questionnaire. It can be concluded that there is a relationship between risk perception and intention to maintain personal hygiene during menstruation. Although the relationship obtained showed a strong relationship, there were some female students that still had wrong perception about personal hygiene maintenance during menstruation.
APLIKASI REGRESI ORDINAL PADA FAKTOR YANG BERPENGARUH TERHADAP AKTIFITAS ENZIM CHOLINESTERASE DARAH (Studi di Dusun Binangun Desa Bumiaji Kecamatan Bumiaji Kota Batu)
Authors: Novariyanto Diky , Wibowo Arief
Published: October 2021

The case of pesticide contamination in Batu City in 2017 wasrelatively high, with the percentage of 82.7%. The case of pesticide contamination could be detected by examining the cholinesterase enzyme activity in blood.The Bumiaji villagers (Batu City) mostly work as a pesticide spray farmers. The study aims to analyze the factors that affect cholinesterase enzyme’s activities on the blood of the farmers who spray pesticide. The study was observational with cross-sectional design and used ordinal regression method. The research sampleswere 81 farmers selected through accidental sampling method. The independent variables of this study were the use of Personal Protective Equipment (PPE) and farmers’work duration. The dependent variable of this study was the cholinesterase enzyme’s activities in the farmers’ blood. The results of the study were that most farmers experienced cholinesterase enzyme activity changes, misused PPE (80.2%), and worked for less than 8 hours each day (92.6%). Based on the ordinal regression analysis, the variables which affected to the cholinesterase enzyme activity of the farmers’ blood was the use of PPE with a p-value of 0.00 <α (0.05). Based on the regression model, the farmers who properly used PPE had 0.12 higher chance to avoid the change of cholinesterase enzyme activity in the blood. It is necessary to held a disseminationabout the use of personal protective equipment to the farmers, as a preventive effort by the district health office, local village office, and the management of farmer groups in Binangun sub-village, Bumiaji Village, Bumiaji Subdistrict, Batu City.
Invariance of information modeling of adjoining territory during the lifecycle
Authors: Honcharenko Tetyana , Mihaylenko Victor , Dolya Elena
Published: October 2021

The article considers the solution of the problem of development of the unified information model of the adjacent territory with additional assets during all life cycle. The proposed parameterization of the creation of a unified model of the object allows integrating the model of management of the adjacent territory in the unified information model of the real estate object. Figs.: 4. Refs.: 14 titles.
Biometric method of personality authentication based on the eye tracking data
Authors: Pavlenko Vitaliy , Shamanina Tetyana , Chori Vladislav
Published: October 2021

A new method of biometric identification of a computer user is proposed based on the Volterra model and eye tracking data in dynamics (eye tracking technology). The instrumental computational and software tools for constructing a nonparametric nonlinear dynamic model (Volterra model) of the human oculo-motor system have been developed on the basis of data from experimental studies "input-output" using innovative eye tracking technology. The obtained multidimensional transition functions are used to construct a biometric identification system for individuals. Figs.: 10. Tabl.: 1. Refs.: 9 titles.
Varus Knee Deformity Classification Based on Degree and Extra- or Intra-Articular Location of Coronal Deformity and Osteoarthritis Grade
Authors: Bagaria Vaibhav , Kulkarni Rajiv V. , Sadigale Omkar S. , Sahu Dipit , Parvizi Javad , Thienpont Emmanuel
Published: October 2021

Background:

Medial coronal plane malalignment, also known as varus alignment, is commonly reported in osteoarthritic knees. Although the degree of deformity provides some insight regarding the severity of the disease, it does not always reflect the potential complexity of the surgical treatment.

Methods:

This prospective observational study was conducted by analyzing the radiographs of 100 consecutive knees in patients undergoing total knee arthroplasty. For each knee, coronal alignment, expressed as the hip-knee-ankle angle, was measured on a full-leg standing radiograph and classified in 3 stages. The primary location of the varus deformity was identified as intra-articular and/or extra-articular. Additionally, knees were evaluated to assess for 10 radiographic features of varus deformity and then classified in 3 grades of osteoarthritis severity.

Results:

The mean (and standard deviation) preoperative varus deformity was 11° ± 6° of varus (hip-knee-ankle, 169°), as measured on standardized full-leg radiographs. Extra-articular varus deformity was observed in 14% of patients. A higher number of radiographic features of varus severity corresponded with higher degrees of deformity. Varus grade correlated strongly with stage of varus deformity. Twenty-three (100%) of 23 stage-III deformities had grade-C features; however, 13 (48%) of 27 stage-I patients also had grade-C disease.

Conclusions:

One of every 7 osteoarthritis patients with varus deformity had an extra-articular deformity, and 1 of 2 of these patients had severe intra-articular disease (grade C) despite limited coronal deformity (stage I). These findings reconfirm the need for individual deformity analysis that accounts for the degree, location, and severity of the varus deformity. This insight may help to formulate an algorithmic treatment approach specific to the epiphyseal knee anatomy of the patient and according to the surgical preferences of the surgeon.

Clinical Relevance:

Knee surgeons tend to consider knees with higher degrees of coronal deformity as more technically difficult, but the present study shows that knees with less deformity can still present with severe grades of osteoarthritis inside the knee, leading to more challenging joint reconstruction.
Long Head of the Biceps Tendon Ruptures
Authors: Panico Leighann , Roy Trinava , Namdari Surena
Published: October 2021

» Pathology of the long head of the biceps tendon is a common source of shoulder pain and often occurs in combination with other shoulder disorders.

» Nonsurgical management, including rest and activity modification, use of nonsteroidal anti-inflammatory drugs, physical therapy, and corticosteroid injections, is usually the first line of treatment.

» Patients with symptoms that are refractory to nonsurgical management are indicated for biceps tenotomy or various tenodesis procedures.

» Although several studies have reported a higher incidence of “Popeye” deformity, muscle cramping, and pain in the bicipital groove postoperatively with tenotomy compared with tenodesis, there are no substantial differences in functional scores or patient satisfaction between the 2 techniques.

» To date, both tenotomy and tenodesis have been shown to be effective options in the management of long head of the biceps tendinopathy, and there are advantages to each procedure.
PD-1 immune checkpoint blockade enhances FLOT chemotherapy toxicity in oesophageal adenocarcinoma cells via immune-independent mechanisms
Authors: davern maria , Brien Rebecca M. O’ , McGrath Jason , Donlon Noel E. , Melo Ashanty A. , Buckley Croí E. , Sheppard Andrew D. , Reynolds John V. , Lynam-Lennon Niamh , Maher Stephen G. , Lysaght Joanne
Published: October 2021

Chemotherapy upregulates immune checkpoint (IC) expression on the surface of tumour cells and IC-intrinsic signalling confers a survival advantage against chemotherapy in several cancer-types including oesophageal adenocarcinoma (OAC). However, the signalling pathways mediating chemotherapy-induced IC upregulation and the mechanisms employed by ICs to protect OAC cells against chemotherapy remain unknown.Longitudinal profiling revealed that FLOT-induced IC upregulation on OE33 OAC cells was sustained for up to 3 weeks post-treatment, returning to baseline upon complete tumour cell recovery. Pro-survival MEK signalling mediated FLOT-induced upregulation of PD-L1, TIM-3, LAG-3 and A2aR on OAC cells promoting a more immune-resistant phenotype. Single agent PD-1, PD-L1 and A2aR blockade decreased OAC cell viability, proliferation and mediated apoptosis. Mechanistic insights demonstrated that blockade of the PD-1 axis decreased stem-like marker ALDH and expression of DNA repair genes. Importantly, combining single agent PD-1, PD-L1 and A2aR blockade with FLOT enhanced cytotoxicity in OAC cells. These findings reveal novel mechanistic insights into the immune-independent functions of IC-intrinsic signalling in OAC cells with important clinical implications for boosting the efficacy of the first-line FLOT chemotherapy regimen in OAC in combination with ICB to not only boost anti-tumour immunity but also to suppress IC-mediated promotion of key hallmarks of cancer that drive tumour progression.
Recyclable Clay-Supported Heteropolyacid Catalysts for Complete Glycolysis and Aminolysis of Post-Consumer PET Beverage Bottles
Authors: Jeya Gopal , Ganesan Elumalai , Tajuddin Aimi Asilah Haji , Ito Yoshikazu , Dhanalakshmi Ravikumar , Sivamurugan Vajiravelu
Published: October 2021

In this investigation, the use of phosphotungstic acid (PWA) and phosphomolybdic acid (PMA) as well as Zn2+ containing kaolin and bentonite explored for chemical recycling of post-consumer poly(ethyleneterephathalate) (PET) wastes have been explored. The clay supported catalysts containing 5wt% of the metals and heteropolyacids (HPAs) are synthesized using wet impregnation method. The effect of metal ions and HPAs loading on the surface area, pore volume, elemental composition and crystalline nature of the kaolin and bentonite has been evaluated by nitrogen adsorption and desorption studies, SEM-EDX mapping, powder XRD, FTIR and XPS analysis. The total surface area of BET increased with a loading of 5 wt% of Zn2+, PWA and PMA on kaolin and bentonite, while the pore volume and pore diameter remain unchanged. SEM and EDAX mapping images showed that the heteropolyacids crystals are well dispersed on the surface and occupied interlayer spaces of the clay support. SEM-EDX showed that bentonite showed a better loading of PWA and PMA compared with kaolin. PET waste water bottles collected from the local market used for the chemical recycling process. The aminolysis reaction using Zn2+ and PWA loaded on bentonite showed complete depolymerisation of PET wastes to produce 87-98% of BHETA. The glycolysis reaction using the above catalysts showed complete depolymerisation at 180-210 °C and yielded 78-90% of BHET. When comparing the clay, bentonite performed well in terms of heteropolyacid loading and afforded a higher yield of BHET and BHETA due to higher loading of Zn and HPA as supported by SEM-EDX and XPS. Reusability of the catalysts were also examined for glycolysis.
The Prevalence of Primary and Secondary Hyperparathyroidism and its Cardiometabolic Implications in Patients with Primary Aldosteronism.
Authors: Araujo-Castro Marta , PASCUAL-CORRALES Eider , Fernández-Argueso María , Rojano Nuria Bengoa , Cano Ana García , Mendiguchía Lucía Jiménez , CUESTA Martín
Published: October 2021

Purpose: To analyze the prevalence of primary and secondary hyperparathyroidism in patients with primary aldosteronism (PA), and its implication on cardiovascular and metabolic outcomes.Methods: A retrospective study of patients with PA (exposed cohort, n=44) and all essential hypertensive (EH) patients with adrenal lesions without PA nor other adrenal hypersecretion (non-exposed cohort, n=41) on follow-up at our center between 2016 and 2020.Results: The mean age of patients with PA and EH was 55.1±14.13 and 66.3±10.93 (P<0.001), and 50% of PA and 39.0% of EH were women (P=0.309). At diagnosis, the prevalence of primary hyperparathyroidism in PA was of 18.2%, and all were normocalcemic hyperparathyroidism cases. Globally, no differences were found in the prevalence of primary hyperparathyroidism compared to EH (18.2% vs 29.3%, P=0.229) but hypercalcemic primary hyperparathyroidism was significantly more prevalent in EH patients than in PA (22.0% vs 0%, P=0.001). There were 47.7% (n=21) cases of secondary hyperparathyroidism in patients with PA (4 due to CKD and vitamin D deficiency and 17 due to vitamin D deficiency alone). The cardiometabolic profile of patients with PA and hyperparathyroidism (n=29) was similar to of those patients without hyperparathyroidism (n=15) at diagnosis and after a median follow-up of 3.6 years [IQR 1.1-5.9].Conclusions: Although primary and secondary hyperparathyroidism are common in patients with PA, their prevalence was similar than the observed in EH patients. Primary hyperparathyroidism is usually mild in PA, presenting as normocalcemic forms. No negative implications of the hyperparathyroidism in the cardiometabolic profile of PA were observed.
Anti-Inflammatory Potential of Liraglutide, a Glucagon-like peptide-1 receptor agonist, in Rats with Peripheral Acute Inflammation
Authors: Mert İrem , Cetinkaya Ayhan , Gurler Mujgan , Turel Canan , Celik Humeyra , Torun Ibrahim Ethem , Turel Idris
Published: October 2021

We tested our working hypothesis that that liraglutide (LRG), a Glucagon-like peptide-1 (GLP-1) receptor agonist, may potentiate the efficacy of tramadol (TR), a synthetic opioid, in acute inflammatory process and may has profound therapeutic effects in controlling the local acute inflammation. The present study aimed to explore the possible anti-inflammatory actions of LRG, TR or their combination treatments by investigating the inflammatory signs such as pain hypersensitivity, edema and fever in carrageenan (CG)-induced acute peripheral inflammation model in rats. The levels of several biomarkers for inflammatory status, angiogenesis and oxidative stress were also measured in inflamed tissues. CG induced inflammation in the paws of rats caused identified by hypersensitivities, redness, edema and fever. LRG, TR or LRG+TR significantly improved the mechanical and cold allodynia, and reduced the edema and fever. LRG dramatically suppressed the inflammatory signs when compared to those of TR. In addition, co-administration of TR and LRG resulted in further reduction of sensitivity to cold and mechanical stimuli. Efficacies of LRG, TR or LRG+TR on inflammatory induced reactions altered depending on inhibition rates in the biomarkers of inflamed paws. Consequently, the suppressive actions of TR, LRG or TR+LRG combination in the inflammation induced hypersensitivities, edema and fever indicates that these drugs have significant anti-inflammatory potential with anti-hypersensitivities, anti-edema and anti-pyretic effects. LRG with anti-inflammatory actions may be a highly promising options for the management of inflammatory conditions or inflammatory related various diseases.
Novel Composite Films Based on Acrylic Fibers Waste / Nano-Chitosan for Congo red Adsorption
Authors: Selim salah , Meligi Gamal A. , Abdelhamid Ahmed E. , Mabrouk Mahmoud A. , Hussain Ahmed I.
Published: October 2021

Dyes are a form of pollutant that has been dumped into water sources by a variety of industries, causing environmental and human health problems. As a result, the current research focuses on recycling acrylic fibers waste combined with nano-chitosan for use as an adsorbent to remove Congo red (CR) from wastewater. Acrylic ﬁbers (AF) waste were mixed with nano-chitosan (NCh) with different ratios and converted into films by using phase inversion method to prepare two nanocomposites films coded, AF-NCh and AF-NCh-Epichlorohydrin. The nanocomposites films have been characterized using; Fourier transform infrared, scanning electron microscope, surface area, and thermal analysis. The results revealed successful incorporation of NCh into AF matrix with highly porous structure. Adsorption studies were carried out to get the optimum condition for CR remediation process. Different parameters were employed such as, CR concentrations, adsorbent dose, effect of time and pH. Langmuir, Freundlich isotherms and kinetic studies evaluations were applied. Results declared that, the maximum adsorption capacities of AF-NCh and AF-NCh-Epichlorohydrin were 166.6 and 232.5 mg/g respectively. The adsorption isotherm and kinetic mechanism obey Langmuir and pseudo second order models. Regeneration of the synthesized composite films were studied for five cycles and showed relative stable reading with high efficiency.
Production of Gas Diffusion Layers with Cotton Fibers for its use in Fuel Cells
Authors: Navarro A. , Gómez M. , Daza L. , Lopez-Cascales J. J.
Published: October 2021

The gas diffusion layer (GDL) plays an important role in a proton exchange membrane fuel cell (PEMFC) transporting the current to the collector plates, distributing the reactant gases to the catalyst surface, and evacuating the heat and water that is generated during the redox reactions. Speaking in terms of production cost, the GDL represents between 30% and 50% of the total cost of the membrane electrode assembling (MEA). However, despite its importance in fuel cells, until recent years, the GDLs have not been studied with the same intensity than other MEA components, such as the catalyst or the proton membrane.
In this work, we present the production process of a low cost GDL family that was developed at laboratory scale, using a non-woven paper-making process. A relevant aspect of these GDLs is that 40% of their composition is natural cotton, despite which they present good electrical and thermal conductivity, high porosity, good pore morphology, high hydrophobicity and gas permeability. Furthermore, when the GDL with its optimum cotton content was tested in a single open cathode fuel cell, a good performance was obtained, that make of this GDL a promising candidate for its use in fuel cells.
Effect of xylazine, detomidine, medetomidine and dexmedetomidine during laparoscopic SCNT embryo transfer on pregnancy rate and some physiological variables in goats
Authors: Samimi Amir Saeed , Aghamiri Seyed Morteza , Hajian Mehdi , Samimi Amir Masoud , Oroumieh Amin
Published: October 2021

Background

The present study was conducted to determine if using α2-adrenergic agonists results in decreased stress levels (lower cortisol levels) in goats used for laparoscopic embryo [somatic cell nuclear transfer (SCNT)] transfer; and there is an effect on pregnancy rate when stress levels are lessened. Sixty healthy does aged 24 ± 4 months and weighing 30 ± 3 kg were used in experimental, prospective, randomized and blinded study. In this study, embryos were created via the Somatic Cell Nuclear Transfer (SCNT) method. Animals were randomly assigned to five groups: control (normal saline); xylazine (100 µg kg−1); detomidine (50 µg kg−1); medetomidine (20 µg kg−1); and dexmedetomidine (5 µg kg−1). Embryo transfer (through laparoscopic technique) began at 15 minutes and continued till 45 minutes post-treatment. Heart rate (HR), respiratory rate (RR), rectal temperature (RT), and ruminal motility were performed before (baseline) and after drug administration. Pregnancy detection was performed 38 days after embryo transfer.
Results

Compared to control, HR, RR and ruminal motility were significantly lower in α2-adrenergic agonists groups at 5–90, 15–60, and 5–120 minutes, respectively. Serum cortisol values significantly increased from baseline in the control group 45 minutes after drug administration (p = 0.001). At T45 and T120, serum cortisol concentration was significantly lower in α2-adrenergic agonists groups compared with the control. The pregnancy rate in control group (n = 4/12, 33.3%) was significantly lower than xylazine (n = 9/12, 75%; p = 0.041), detomidine (n = 10/12, 83.3%; p = 0.013), medetomidine (n = 9/12, 75%; p = 0.041) and dexmedetomidine (n = 10/12, 83.3%; p = 0.013); but no significant differences were observed among different α2-adrenergic agonists groups.
Conclusion

Alph2-adrenergic agonists are effective on increasing the pregnancy rate of SCNT embryo transfer in goats in this study. No significant differences were detected among different α2-adrenergic agonists.
The Best Choice for Low and Moderate Myopia Patients Incapable for Corneal Refractive Surgery: Implantation of a Posterior Chamber Phakic Intraocular Lens
Authors: Wang Qin , Fan Lina , Zhou Qizhi
Published: October 2021

Purpose To assess the early clinical outcomes of central hole phakic posterior chamber intraocular lens(ICL V4c) implantation for correction low and moderate myopia, and to explore the relationship among arch height, intraocular pressure(IOP), and central anterior chamber depth(ACD). Methods This retrospective clinical study included 27 patients (47 eyes)which underwent implantation of ICL V4c for correction of myopia with spherical equivalent between -1.75 D and -6.0 D, From January 2017 to December 2018. Preoperative corrected distance visual acuity (CDVA), postoperative uncorrected visual acuity (UCVA), and IOP were evaluated at one day, one week, three mouths, six mouths, and twelve months. ACD, arch height, and endothelial cell density (ECD) were evaluated at one, three and twelve months. Results At 1 year follow-up, the UCVA of 75% eyes are larger than the preoperative CDVA, and that of 25% eyes are equal to the preoperative CDVA. The postoperative UCVA of the patients was higher than the preoperative BCVA and showed a stable trend. There was no significant difference in ECD (P > 0.05). One month after surgery, the arch height was (0.77 ±0.32) mm, and decreased to (0.63 ± 0.26) mm at the one-year after surgery. ACD was (3.24±0.25) mm in the preoperative, decreased significantly to (2.05±0.39) mm at one month, and rose to (2.2± 0.39) mm at one year after surgery. There was no significant correlation between IOP and ACD and arch height at 1 month and 1 year after operation. The correlation coefficient between ACD and arch height was -0.72 at 1 month after surgery, and it was -0.71 at 1 year. One patient had visual fatigue, one patient had glare, and none of subjects developed cataract, glaucoma and decompensation of corneal endothelium. Conclusion ICL implantation is a safe, effective and stable method for the correction of low and moderate myopia, and it may be a good alternative for patients with low and moderate myopia who cannot undergo corneal refractive surgery.
Integrated Transcriptome-Wide Profiling And Protein Structure Analysis of Pathogenic Genes In Venous Thromboembolism
Authors: Ding Jing , Zhang Yan , Che Yan
Published: October 2021

Background: Genetic factors are considered to determine the balance of the coagulation and anticoagulation processes, yet the genetic variants related to venous thromboembolism (VTE) remain unclear. This study aimed to investigate the potential molecular mechanisms and pathogenic mutations associated with VTE by determining VTE-related differentially expressed genes (DEGs) by transcriptome-wide profiling and assaying protein structure in VTE.Methods: Two gene expression datasets, GSE48000 and GSE19151, were accessed from the Gene Expression Omnibus (GEO) database to obtain gene expression data associated with VTE. We identified the DEGs between VTE patients and healthy people using R and performed functional enrichment analysis, including Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. Then, whole-exome sequencing (WES) was performed for 25 VTE patients and 17 normal cases, and the structural locations of pathogenic missense mutations were identified using pyMOL. Finally, DGIdb database was used to select candidate drugs for the treatment of VTE.Results: A total of 232 DEGs were identified from the GEO database. The significant function of these DEGs was mostly involved in RNA catabolic process and ribosome pathway. Notably, the results of WES for DEGs and protein structure analysis showed that Histamine N-Methyltransferase (HNMT) (chr2: 138759649 C>T, rs11558538) may be a main predisposing factor for VTE. In addition, Amodiaquine, Harmaline, Aspirin, Metoprine, Dabigatran, and Diphenhydramine were screened for VTE therapy.Conclusion: The results showed that HNMT (chr2: 138759649 C>T, rs11558538) may be potential target for the diagnosis and treatment of VTE.
Maffucci Syndrome Complicated by Giant Chondrosarcoma in the Left Ankle with an IDH1 R132C Mutation: Case Report
Authors: Lv Haiyan , Jiang Hantao , Zhang Minge , Luo Huarong , Hong Zhenghua , Yang Hai , Xu Weiming , Shen Bo , Zhu Rangteng
Published: October 2021

BackgroundMaffucci syndrome is a rare, nonhereditary congenital mesodermal dysplasia characterized by multiple enchondromas and hemangiomas. It is associated with an increased risk of the development of malignant tumors. We present a case of 45-year-old man with Maffucci syndrome to supplement the clinical manifestations and explore the molecular mechanism of Maffucci syndrome.Case presentationThe patient was underwent amputation surgery to inhibit tumor development and diagnosed as Maffucci syndrome with 1-2 grade giant chondrosarcoma in the left ankle. In addition, the whole exon analysis by Next Generation Sequencing revealed isocitrate dehydrogenase 1 R132C mutation in chondrosarcoma lesions but not in blood DNA.ConclusionsThis case report presents the genetic evidence for the inclusion of chondrosarcoma among tumors characterizing Maffucci syndrome. Consequently, it is suggested that the patient with Maffucci syndrome should be followed up more actively to exclude neoplasms due to IDH1 R132C somatic mutation.
A Comparative Study of O and Hf Vacancies in Cubic Hfo2 From First-principles Study
Authors: Zhang Ning-Chao , Ye Xin , Liu Zheng-Tang , Jiang Cheng lu , Liu Qi-Jun
Published: October 2021

First-principles study of cubic HfO2 with O and Hf vacancies was carried out with the plane-wave ultrasoft pseudopotential technique within the generalized gradient approximation (GGA). The crystal structure of cubic HfO2 with O and Hf vacancies was optimized. The band structure, electronic-state density, complex dielectric function, refractive index, extinction coefficient, complex conductivity function, loss function, absorption coefficient and optical reflectivity in pure, O vacancy and Hf vacancy cubic HfO2 were calculated. Compared to the pure cubic HfO2, we find that the O vacancy and Hf vacancy cubic HfO2 are some changes in electronic structure. The Fermi surface extends into the conduction band of the O vacancy cubic HfO2 and the Fermi surface extends into the valence band of the Hf vacancy cubic HfO2.
Dynamic Analysis of AC-DC Microgrid with Aid of Golden Search with Flower Pollination Algorithm
Authors: S Mythili , N Narasimhulu
Published: October 2021

In recent years, the power system stability enhancement and power flow analysis are essential task in AC-DC microgrid system. Hence, in this paper, Golden Search-based Flower Pollination Algorithm (GSFPA) to solve the optimal power flow invention in AC-DC microgrid system. In the projected methodology, the objective functions are framed to enable the optimal power flow in microgrid system such as total cost of generation in AC as well as DC systems and cost of active power transmission to DC grid from AC microgrid. The objective functions are related with the constraints such as AC-DC power electronics converters limits, power flows and voltage magnitude limits. Additionally, power loss and voltage deviation of the microgrid system also reduced which enhance the system performance. The proposed methodology is utilized to select optimal control parameters for enabling the stable operation of microgrid system. The proposed methodology is validated by using IEEE 30 bus system which associated with 9-bus DC microgrids and 6-bus DC microgrids. The projected method is applied in MATLAB and performances are analyzed with normal as well as contingency conditions. The projected method is contrasted with the conventional methods such as Flower Pollination Algorithm (FPA), chaos based FPA (CFPA) and Levy Flight based Black Widow Optimization (LF-BWO) respectively.
Clinical Significance of Discordances in Sentinel Lymph Node Reactivity Between Radioisotope and Indocyanine Green Fluorescence in Patients With cN0 Breast Cancer Patients
Authors: Jimbo Kenjiro , Nakadaira Uta , Watase Chikashi , Nurata Takeshi , Shiino Sho , Takayama Shin , Suto Akihiko
Published: October 2021

Background: To evaluate the usefulness of combining radioisotopes and indocyanine green (ICG) and investigate discordances in sentinel lymph node (SN) reactivity using each tracer in cN0 breast cancer patients.Methods: 338 cN0 primary breast cancer patients who underwent SN biopsy with radioisotopes and ICG and axillary lymph node (ALN) dissection were included. SN positivities with radioisotopes, ICG, and both were denoted as SN(RI), SN(ICG), and SN(RI+ICG), respectively. We retrospectively estimated metastatic SN detection rates, each method’s discordance rate, and correlation of discordances in SN reactivity with postoperative N staging.Results: The combination of radioisotopes and ICG had higher metastatic SN detection rates (99.7%) than radioisotopes or ICG alone (91.7% and 96.4%, respectively; p<0.01). The discordance rate between SN(RI) (11 cases) and SN(ICG) (27 cases) in detecting metastatic SNs was 11.2%. The absence of SN(RI), cT stage (cT2-3), higher histological grade, and histological type were identified as risk factors of pN2-3 disease (odds ratios: 8.64, 2.56, 1.92, and 3.28, respectively; p<0.01).Conclusions: Discordances in SN reactivity between radioisotopes and ICG helps identify SN metastasis. Although the absence of SN(RI) is rare, it is a significant sign of advanced ALN metastases; ALN dissection should be considered for accurate nodal staging.
A Multimodal Concept for Vaginal Cuff Closure by Modification of the Bakay Technique in Total Laparoscopic Hysterectomy: A Randomized Clinical Study
Authors: Kalkan Üzeyir , Bakay Kadir
Published: October 2021

Background: The aim of this study was to compare the outcomes of modified Bakay technique (MT) to standard colpotomy (ST) and cuff closure in total laparoscopic hysterectomy (TLH). Methods: This two-centre, randomized-controlled study included a total of 160 patients who were scheduled for TLH for benign diseases (ClinicalTrials.gov Identifier is NCT05080114 and the first posted date was 15/10/2021). The patients were allocated into two groups by a computer-based randomization programme as ST group and MT group. Total operative time, cuff closure time, length of hospital stay, intra- and postoperative complications according to the Clavien-Dindo classification, pre- and postoperative vaginal length, and patient satisfaction according to the Patient Global Impression of Improvement (PGI-I) questionnaire were assessed. Results: Seventy-seven patients in the ST group and 80 patients in the MT group underwent TLH. The total operative time was significantly shorter in the MT compared to the ST (59 vs. 55.5 min, respectively; p=0.001). The median total operative time for colpotomy, extraction of uterus, and vaginal cuff closure steps was 9 (range, 6 to 12 in MT vs. 6 to 11 in ST) min in both groups. The median hospital stay was 2 (range, 1 to 4) days in both groups. Intraoperative blood loss was not significantly different between the groups (90 mL in ST vs. 80 mL in MT; p=0.456). The mean uterine weight for the ST group and MT group was comparable (258.6±88.6 g vs. 232.9±102.5 g, respectively; p=0.107). The preoperative vaginal length was not significantly different between the groups (p=0.502). The median postoperative vaginal length was significantly higher in the MT group compared to the ST group on Day 90 (8 cm vs. 7,5 cm, respectively; p= 0.001). The PGI-I questionnaire score on Day 90 postoperatively was 2 (range, 1 to 5) in both groups (p=0.636). The complication rates were similar between the groups (p=0.230).Conclusion: The MT can be safely performed in most of the cases requiring TLH with the advantages of vaginal cuff closure before the alteration of pelvic anatomy, support to primary healing of the vaginal cuff, and routine concomitant apical support.
The Comparison of CSN2 (rs43703011) Beta-Casein Gene Options Frequencies in Different Breeds of Ukraine Cows and the Prospect of Creating Herds with the A2/А2 Genotype
Authors: Ladyka Volodymyr , Drevytska Tetiana , Pavlenko Yuliia , Skliarenko Yuriy , Lahuta Tetiana , Drevytskyi Ostap , Dosenko Victor
Published: October 2021

Using real-time polymerase chain reaction methods, we have researched the CSN2 polymorphism (GenBank M55158; SNP rs43703011) gene in 4 breeds of cows in the North-East of Ukraine. The observed distributions of genotype frequencies А1/А1, А1/А2, А2/А2 and A1 or A2 alleles varies considerably in different cattle breeds: Lebedyn cattle - 14.6%, 31.7%, 53.7% (0.3 and 0.7); Ukrainian brown dairy breed - 6.8%, 43.2%, 50% (0.28 та 0.72); Simmental cattle - 7.3%, 51.2%, 41.5% (0.33 and 0.67); Ukrainian black speckled milky – 38.5%, 34.6%, 26.9% (0.56 та 0.44). The ratio of genotypes and alleles were found significant differences when comparing Lebedyn cattle and Simmental cattle (р=0.01), Lebedyn cattle and Ukrainian black speckled milky (р<0.0001), Lebedyn cattle compared to all other breeds (р=0.04), Ukrainian brown dairy breed and Ukrainian black speckled milky (р<0.0001), Ukrainian brown dairy breed compared to all other Ukrainian breeds (р=0.008); Simmental cattle and Ukrainian black speckled milky (р<0.0001), Simmental cattle (р=0.002) and Ukrainian black speckled milky (р<0.0001) to all other breeds. The obtained results indicate the prospects of breeding work to create herds with genotype A2/A2 animals - specifically with the Lebedyn cattle.
Systemic COVID-19 vaccination also enhances the humoral immune response after SARS CoV-2 infection in the population of an oncology hospital in Poland. Criteria for COVID-19 re-immunization are needed.
Authors: Kosiorek Piotr , Kazberuk Dorota , Hryniewicz Anna , Milewski Robert , Stróż Samuel , Stasiak-Barmuta Anna
Published: October 2021

Systemic vaccination of the BNT162b2 mRNA stimulates humoral response. The aim of our study was to compare the intensity of humoral immune response, measured by SARS CoV-2 IgG, SARS CoV-2 IgM, and neutralization S-RBD IgG antibodies level, post COVID-19 vaccination versus post SARS COV-2 infection. We analysed 1060 people in the following groups: convalescents, healthy vaccinated, vaccinated with COMIRNATY, AstraZeneca, Moderna, Johnson&Johnson and vaccinated SARS CoV-2 convalescents. A concentration of SARS CoV-2 IgG, SARS CoV-2 IgM, and neutralizing S-RBD IgG was estimated in Bialystok Oncology Center laboratory by chemiluminescent immunoassay- CLIA, MAGLUMI. Results: 1. We observed a raise of antibodies response in both, convalescent SARS CoV-2 and COVID-19 vaccinated groups 2. The level of all antibodies’ concentrations in vaccinated COVID-19 convalescents was significantly higher. 3. We differentiated an asymptomatic SARS CoV-2 convalescents from control group. Based on our analysis we suggest that it is important to monitor SARS CoV-2 antibodies concentrations as an indicator of asymptomatic COVID-19 infection, and as an equivalent of effectiveness of humoral response in convalescents and vaccinated people. Taking into consideration the time-limited nature of the effects of post infection SARS CoV-2 recovery or vaccination, among others physiological half-life, we suggested monitoring IgG antibodies level as a criterium for next vaccination.
Carbon Dioxide Emissions Mitigation Strategy through Enhanced Geothermal Systems: Western Anatolia, Turkey
Authors: Chandrasekharam Dornadula , Baba Alper
Published: October 2021

Although Turkey is not the biggest GHG polluter, its emissions have increased by 110.4 % since 1990. Currently, its CO 2 emissions alone have crossed 400 Mt. Within the scope of 2 °C targets (2D scenario), the country can easily surpass this target test by increasing its renewable energy sources as a primary energy source mix, by developing its Enhanced Geothermal Sources (EGS) locked up in the radiogenic granites of western Anatolia. The radiogenic heat generated by these granites, spread over an area of 4221 sq. km, varies from 5.3 to 16.34 µW/m 3 . Based on the electricity generation capacity of granites from Soultz-sous-Forets and Cooper Basin EGS sites, the combined electricity generation capacity of Kestanbol and Kozak granite plutons is about 830 billion kWh. For the period extending from 2019 to 2023, Turkey is aiming at reducing the usage of gas for electricity generation from 29.9 to 20.7%, increasing the share of renewable energy sources from 32.5 to 38.8%, increasing the electricity production from local energy sources from 150 TWh to 219 TWh and increasing the electricity usage per-capita from 3.7 to 4.3 MWh. These energy targets can be achieved by major contributions from hydrothermal and EGS energy sources. This review demonstrates that besides electricity and heat, EGS energy can be utilized, together with other renewable energy sources like hydrothermal, wind, and concentrated solar for providing fresh water through the desalination process. These energy sources would provide food, energy, and water security to the country for several decades.
EfficAcy and Safety of Tripterygium Wilfordii Multiglycosides in Idiopathic Membranous Nephropathy (EAST): Protocol for An Open-Label Randomized Controlled Clinical Trial
Authors: Geng Chanyu , Feng Yunlin , Li Qiang , Pu Lei , Yang Hongling , Li Guisen
Published: October 2021

Background
Idiopathic membranous nephropathy (IMN) is one of the most common primary glomerular diseases in China, especially in the elderly. Patients who are classified as low risk of renal function decline based on KDIGO guidelines often present with obvious lower extremities edema, which make the supportive treatment of RAS inhibitors less accepted. Tripterygium wilfordii multiglycosides has been used to treat rheumatic disease over years in China, and has been demonstrated to have the effect of reducing proteinuria and alleviate edema in patients with chronic kidney disease.
Methods
This is an open-labeled, randomized, controlled clinical trial. Twenty patients with IMN who meet the inclusive criteria will be randomly assigned into the intervention group and the control group at a rate of 1:1. The intervention group was treated with tripterygium wilfordii multiglycosides tablets (1-1.5mg/kg body weight, oral administration after three meals) in addition to the original dose of ACEi/ARB, while the control group continued with the original dose of ACEi/ARB. The treatment course is six months, and the clinical data of patients will be collected at baseline and at each monthly follow-up. The primary outcome measure is the absolute value of relative baseline decrease of urinary protein quantity after six months treatment. The secondary outcome measures include absolute value of relative baseline decrease of ACR in morning urine after 6 months treatment, the percentage of patients who reached the standard of effective clinical treatment, and complex renal end point events. Safety outcome measures include the incidence of adverse events, the incidence of serious adverse events, changes in laboratory safety indicators, and death.
Discussion
This study aims to provide higher-level evidence of evidence-based medicine for tripterygium wilfordii multiglycosides in the treatment of this disease, and hopefully has important significance for clinicians who are to make therapeutic decisions of IMN.
Trial Registration:
This trial has been prospectively registered in Chinese Clinical Trial Registry (identifier# ChiCTR2100048382) on 6 July 2021.
Trial status:
Recruiting. Recruitment is expected to be completed in June 2020.
Measured distribution of cloud chamber tracks from radioactive decay: a new empirical approach to investigating the quantum measurement problem
Authors: Schonfeld Jonathan
Published: October 2021

Using publically available video of a cloud chamber with a very small radioactive source, I measure the spatial distribution of where tracks start, and consider possible implications. This is directly relevant to the quantum measurement problem and its possible resolution, and appears never to have been done before. The raw data are relatively uncontrolled, leading to caveats that should guide future, more tailored experiments. Track distributions from decays in cloud chambers represent a previously unappreciated way to probe the foundations of quantum mechanics, and a novel case of wavefunctions with macroscopic signatures.