bluuebunny/crossref_metadata_2025 huggingface dataset:
Vocation and Mobility as Significant Modifiable Determinants For Quality Of Life Among Oral And Throat Cancer Patients - A Hospital Based Study From Southern India
Authors: Jain Smriti , Susila T  , Duraisamy Senthil Arasi , Krithiga Sivakumar  , Sameeya Furmeen Salam  , Punithakumary P  , Seenivasan P
Published: April 2023

Background: Quality of Life (QOL) is an important indicator of treatment outcome for cancer therapies. QOL researches help us to explore about the impairment caused by treatment and disease on one’s social life, day to day activities and psychological conditions. The objective is to assess the health related QOL in patients suffering from oral cavity and throat cancer and to find out factors associated with QOL.
Methodology: Facility based cross sectional study design with consecutive sampling was used to achieve a sample size of 90 patients with oral cavity and throat cancer.
Result: 71(78.88%) of study participants were independent and 19(21.11%) were partially dependent, none were completely dependent. Majority of the study population perceived a poor overall QOL as revelled by the findings that only 24.4% had best scoring in overall QOL domain. Weak Positive Correlation (R2=0.224) was seen between physical and socio- emotional component of QOL (p value <0.001). Education and cancer site were significantly associated with physical component while employment and Activity of Daily Living were associated with social component of QOL.
Conclusion: There is a need to focus on ambulatory and vocational rehabilitation along with pain management for oral & throat CA patients as the study show an association of these factors with social component of QOL.
Van Gedragsregels naar een Gedragscode
Authors: Nunes O.L. , de Jong S.F.
Published: April 2023

Van Gedragsregels naar een Gedragscode

De KNMG-Gedragscode voor artsen heeft de KNMG-Gedragsregels in 2022 vervangen. Met de nieuwe Gedragscode wordt vooral beoogd om met een vijftiental kernregels BIG-geregistreerde artsen een eigentijdse leidraad voor professioneel handelen te bieden. Behalve oude, vertrouwde uitgangspunten bevat de Gedragscode ook nieuwe kernregels, waarvan de arts zich bewust dient te zijn.
Comparative Study between Excision with Primary Closure versus Flap Reconstruction in Management of Sacrococcygeal Pilonidal Sinus
Authors: Eldsoky Eldsoky Saleh , Atwa Nagah Salem , Naroz Mohamed Ibrahim , Hifny Abdelhameed
Published: April 2023

Introduction and aim: Pilonidal sinus (PNS) is a common inflammatory condition of the gluteal region. Different methods were introduced for treatment. However, recurrence is still a significant problem after surgery and different approaches were described to lower the recurrence rate. But controversy exist regarding the standard surgical intervention. The current work aimed to compare between excision with off midline primary closure versus Limberg flap procedure in the treatment of sacrococcygeal PNS.

Methodology: Sixty patients with PNS were included and divided into two equal groups, the first for primary midline excision with closure, and the second treated by Limberg flap. Patients were assessed by clinical evaluation and after surgery, the recurrence rate was documented through the first year. In addition, complications rate and times to restore the normal daily activities were documented and compared between groups.

Results: Both groups were comparable regarding all preoperative variables. The operative time was significantly short among group I than group II (31.6± 6.5 vs 51.6± 6.4 minutes). The duration of hospital stay, time to return to work, drainage amount, time to stitch removal, time to walk pain-free and time to painless toilet seat were significantly shorter in group I. However, cosmetic score was significantly higher in group I than group II. Finally, the recurrence rate was significantly higher in group I than group II (20.0% vs 0.0%). The recurrence was significantly associated with hairy skin, positive family history, diabetes mellitus, higher BMI, and history of previous PNS.

Conclusion: Primary midline closure of PNS is superior than the Limberg flap in operative time and times to return to normal daily activities. However, it had a higher recurrence rate. Thus, Limberg flap is advocated for PNS.
Economia circular e supermercados: um modelo de negócio
Authors: De Medeiros Diego Derick Oliveira , Queiroz Jamerson Viegas , Queiroz Fernanda Cristina Barbosa Pereira , Marques Eduardo Lopes , da Silva Christian Luiz , Furukava Marciano , Lima Nilton Cesar
Published: April 2023

O artigo aborda a cadeia e gestão produtiva dentro de redes de supermercados varejistas, a partir da observação de oportunidades de desenvolvimento de um novo método de produção baseado na otimização da utilização dos recursos disponíveis em suas instalações. Tendo como objetivo desenvolver um framework de um modelo de negócios, baseado na economia circular para a gestão de produtos de fabricação própria e perecíveis em supermercados. Dessa forma, são tomados como referência os temas relacionados à gestão de produção, planejamento, reutilização e sustentabilidade, desenvolvendo um modelo a ser efetivamente implantado, com padronização e qualidade. O estudo deu-se através do desenvolvimento de duas etapas: a primeira, exploratória, que tratou da revisão teórica e construção do modelo de análise; e, a segunda, de cunho conclusivo, concretizada mediante a realização do levantamento de dados como vendas, perdas, produções e índices de utilização dentro dos processos de produção presentes em uma grande rede de supermercado. A metodologia adotada segue como base estudos bibliográficos e estudos de situações e soluções de problemas de campo, de coleta de dados numéricos através do sistema Consinco e SAP, que após análises, servem de base para fundamentação e tomadas de decisões através dos indicadores estabelecidos. Por fim, tem-se como resultado final, a apresentação de um modelo de negócios inovador, sustentável e rentável, baseado em alicerces seguros através de informações fidedignas e processos claros no aspecto de produções próprias de alimentos.
Optimización de la eficiencia energética en el proceso de extracción de aceite de palma africana
Authors: Valdez Rosales Saul , Leon Cueva Wilson , San Martin Torres Delly
Published: April 2023

El presente proyecto de investigación tiene como objetivo optimizar el proceso de extracción de aceite de palma africana de la planta San Daniel mediante el aprovechamiento de energía residual para generar un ahorro energético. Se realizó un diagnóstico inicial a condiciones de operación estacionarias en donde se tomaron los datos operacionales de los paneles digitales de la planta durante varios días.
The Use of Song to Improve Students' Listening Skill of Ninth Grade at SMPN 1 Jember
Authors: Hafid Hafid , Laili Ela Nur
Published: April 2023

This study investigated the development of students' listening abilities through songs and lyrics and explored the students’ responses toward the use of songs and lyrics in the classroom as a learning media. It was aimed at looking for the best strategy used in the listening class to help students easily mastering English language. This study was conducted through classroom action research and employed pre-test, post-test, observation, questionnaire, and interview to collect the data. The data in this study were analysed by using quantitative and qualitative descriptive. This classroom action research was conducted in two cycles. The quantitatively obtained data in the first cycle showed that mean is about 80 which mean that there was an improvement but was not significant from the pre-cycle because the grammar focus was uncovered. Meanwhile, the data in the second cycle showed that the mean is about 87; it showed the significant increase and successful process of learning throughout songs and lyrics. Furthermore, the qualitative data demonstrated 84% which means that the use of songs and lyrics in the classroom was attractive and joyful to be applied in the classroom as a learning media.
Pelatihan dan Sosialisasi Automated Trading Systems & Autopilot Manual Trading
Authors: Salam Abdus , Wani Cut Eva , Nasir  , Farnita Irma , Ismail  , Alfina  , Imilda
Published: April 2023

Automated Trading Systems & Autopilot Manual Trading training for 6 days on 10-15 January 2023 provides an understanding of the concepts and workings of ATS and AMT as well as risk management in trading. This training is expected to make participants more independent in trading and able to maximize the use of ATS and AMT to gain profits in their investments. In addition, this training is expected to make a positive contribution in increasing financial literacy and investment in society. However, this needs to be done in a structured and comprehensive manner so that capital market participants understand the potential risks that may arise when using Automated Trading Systems and Autopilot Manual Trading in their investment activities. The recommendation that can be made is to hold regular training and outreach, both by regulators, securities companies, and capital market associations. With effective training and outreach as well as strict supervision, it is hoped that capital market players will be able to optimize their investment potential by avoiding unwanted risks. This training can also help increase awareness and understanding of sharia compliance in investing in the Indonesian sharia capital market.
Sosialisasi Pencegahan Tindak Pidana Korupsi dengan Menggunakan Metode Pembelajaran Berbasis Masalah pada TK Al-Kawanad
Authors: Zainuddin  , Ramli  , Hasyim Syarifuddin , Ajinar  , Mistiar Wolly , Saleh Adi , Afriani  , A’zizah
Published: April 2023

Corruption has become a serious problem in Indonesia and the prevention of corruption needs to be done from an early age. One effort that can be taken is to conduct socialization on corruption prevention through problem-based learning methods at TK Al-Kawanad. This method can help children understand the dangers of corruption and how to prevent it through direct experience in solving corruption problems. This study aims to analyze the effectiveness of problem-based learning methods in socializing corruption prevention at TK Al-Kawanad. The research method used is qualitative with data collection techniques through observation, interviews, and documentation. The results show that problem-based learning methods are effective in improving children's understanding of the importance of corruption prevention and how to prevent it. In addition, children are also more motivated and involved in learning through this method. This study is expected to provide a positive contribution in efforts to prevent corruption in Indonesia through character education from an early age.
Research on high-quality development marketing of scenic spots in the post epidemic era
Authors: Zhang Rong
Published: April 2023

Under the influence of the epidemic, the number of tourists and the overall income of the Gulongshan Grand Canyon has been greatly reduced, which also highlights the problem that the Gulongshan Grand Canyon is susceptible to external factors due to its sensitivity and vulnerability. Two years after the start of the epidemic, it was not able to resume development. In the late stage of the epidemic, the domestic epidemic entered a state of steady development, but there were still cases of infection rebounding.

At the same time, the overseas epidemic has spread widely and entered a state of high incidence of cases. The Guangxi Gulongshan tourism market itself has not fully recovered, and the development of the overseas tourism market has been restricted, making the recovery of the Gulongshan Grand Canyon even more difficult. The traditional development is also severely limited, so we will use the 4P and swot theory to analyze the current situation of the Gulongshan Grand Canyon, and at the same time refer to the literature review at home and abroad, correctly view the challenges brought by these epidemics, seize the emerging opportunities, and discuss The strategy for the recovery and development of the Gulongshan Grand Canyon after the outbreak of the epidemic will promote the innovation and sustainable development of the Gulongshan Grand Canyon. This topic includes the following aspects: one is to analyze the current situation of the impact of the epidemic on the Gulongshan Grand Canyon scenic spot; the second is the opportunities and challenges faced by the Gulongshan Grand Canyon in the post-epidemic era; the third is the countermeasures and suggestions for the marketing of the Gulongshan Grand Canyon in the post-epidemic era. This paper completes the writing of this topic from these three aspects.
Augmented Reality (Ar) In Learning Social Science (Ips) In Elementary Schools
Authors: Salmiyanti Salmiyanti , ERITA Yeni , PUTRI Rati Syafiana , NIVETIKEN NIVETIKEN
Published: April 2023

The Augmented Reality is an interactive medium, namely virtual images that are integrated into real life. The study employs literature review, especially by using secondary data obtained by summarizing several research articles related to the use of media which are carried out with the aim of describing and interpreting relevant information related to the use of augmented reality media. The study results are: 1) IPS learning in elementary schools is intended for students to become human beings and good citizens, as expected by themselves, their parents, society and religion; 2) Learning Media can make it easier for someone to convey a material or information to listeners; 3) AR media as a technology that objects in two or three dimensions in a certain way. AR media provides space for students to improve their learning process
Yalnızlık Damgası Ölçeği: Türkçe geçerlik ve güvenirlik çalışması
Authors: ŞENAY Nilay , BİLGE Yıldız
Published: April 2023

Bu çalışmanın amacı Yalnızlık Damgası Ölçeği’nin (YDÖ) Türkçe’ye uyarlama ve geçerlik

güvenirlik çalışmasının yapılmasıdır. Çalışma örnekleminin yaş aralığı 18 ile 57 (21.79±3.60) olan 285

(%59) kadın, 196 (%40.6) erkek ve 2 (%0.4) diğer olmak üzere toplam 483 üniversite öğrencisinden

oluşmuştur. Psikoloji bölümü öğrencisi olan 33 kişilik bir katılımcı grubuna 3 hafta arayla test-tekrar

test uygulaması yapılmıştır. Ölçüt geçerliliği kapsamında 239 katılımcıya YDÖ ile birlikte UCLA

Yalnızlık Ölçeği, Depresyon-Anksiyete-Stres Ölçeği (DASS-21), Kısa Psikolojik Sağlamlık Ölçeği

(KPSÖ) uygulanmıştır. Ölçeğin faktör yapısını belirlemek amacıyla açımlayıcı ve doğrulayıcı faktör

analizleri (AFA ve DFA) yapılmış, varimax döndürme yönteminin kullanıldığı AFA’da orijinal

çalışmada olduğu gibi özdeğeri 1’in üzerinde olan iki boyutlu bir yapının oluştuğu saptanmıştır. DFA

sonucunda ise iki faktörlü yapının herhangi bir modifikasyon yapılmadan doğrulandığı ve uyum

indekslerinin kabul edilebilir bir düzeyde olduğu görülmüştür. Ölçek güvenirliği kapsamında YDÖ’nün

Cronbach alfa iç tutarlılık katsayısı hesaplanmış, toplam ölçek için Cronbach alfa katsayısı .91, alt

boyutlar için ise Cronbach alfa iç tutarlılık katsayıları .80 ve .91 olarak tespit edilmiştir. Ölçeğin testtekrar test korelasyon katsayısı toplam ölçek için r=.47, öz-damgalama için r=.58 ve sosyal damgalama

için r=.45 olarak bulunmuştur. YDÖ’nün ölçüt geçerliği için yapılan korelasyon analizleri sonucunda

anlamlı ilişkiler saptanmıştır. Sonuçlar ölçeğin Türkçe versiyonunun geçerli ve güvenilir olduğunu

göstermiştir.
MENINGKATKAN KEMAMPUAN MENGENAL BENTUK GEOMETRI DASAR PADA ANAK KELOMPOK A MELALUI METODE TEBAK GAMBAR
Authors: Mochamad Surya Candra , Zulvian Iskandar Yogha , Marlina Leni
Published: April 2023

Penelitian ini bertujuan untuk mengetahui peningkatan kemampuan mengenal bentuk geometri melalui metode tebak gambar pada kelompok A POS PAUD Cempaka. Penelitian ini menggunakan metode Penelitian Tindakan Kelas (PTK) dengan membagi kedalam dua siklus dan setiap siklusnya melalui tahap perencanaan, pelaksanaan, observasi, dan refleksi. Alat pengumpulan data utama adalah melalui lembar chek list dan hasil observasi. Subjek penelitian adalah anak Kelompok A POS PAUD Cempaka jumlah anak sebanyak 18 orang anak. Hasil penelitian menunjukkan kemampuan mengenal Bentuk Geometri memiliki presentae yang cukup baik. Sebelum tindakan dilakukan pemahaman bentuk geometri hanya sebesar 33%. Yang meningkat pada tindakan siklus I menjadi 40%, peningkatan kembali menjadi 85% dan telah memenuhu indikator pencapaian keberhasilan minimal 85% dengan kategori baik sekali. Anak kelompok A sudah mampu mengenal, menunjukkan dan mengelompokkan bentuk geometri dengan baik, kepada guru hendaknya terus meningkatkan kompetensinya dalam mengajar sehingga pemahaman anak pada materi yang diajarkan dapat lebih. Pemahaman melalui metode tebak gambar adalah salah satunya.
BIOLOGICAL ACTIVITY OF CITRULLUS COLOCYNTHIS L EXTRACTS ON CULEX PIPIENS MOLETHUS AND MUSCA DOMESTICA
Authors:   Department of Plant Protection, Faculty of  Agriculture, Kufa University, Iraq, Alnomani Khudheyer A , Ali Abdulla Nezar , Mubasher M
Published: April 2023

The two most hazardous vectors for humans are Culex pipiens molethus and Musca domestica. Several environmental and health issues have emerged because of the overuse of chemical pesticides. This study sought to determine the efficacy of aqueous, alcohol, and oil extracts of Citrullus colocynthis L. plant under in vitro conditions using different concentrations (0, 5, 10, and 20 mg/mL) on the various stages of Culex pipiens molethus and Musca domestica. It also sought to identify natural biological alternatives to synthetic insecticides. The current research revealed that the adult and juvenile stages of mosquitoes and house flies were considerably impacted by the extracts of bitter melon. Concentrations demonstrated a distinct effect and significantly outperformed the control treatment after 24, 48, and 72 hrs of exposure. Compared to other bitter melon extracts, the impact of the oil extract of C. colocynthis was superior. At a dosage of 20 mg/ml, oil extract treatment significantly reduced hatchability and increased mortality in the second and fourth larval stages of C. pipiens molethus. The outcomes also demonstrated the superiority of the oil extract of C. colocynthis in influencing the different stages of the house fly M. domestica with the same previous concentrations (20, 10,5 mg/mL) on egg productivity (22, 72, 89, 82%) and third larval instar (66, 79, 71, 94, 82.88%) mortality rates, as well as pupae weight rates (0.10, 0.11, 0.100 mg). With the help of the current study's findings, we may suggest using bitter melon extracts, particularly the oil extract, as a potentially effective control measure against mosquitoes and house flies. These naturally occurring extracts, which do not contain any industrial chemicals, are difficult for the insect they are intended to kill to withstand. For the aim of understanding the mechanism of action of these extracts on mosquitoes and house flies, as well as understanding the effect of bitter melon extracts on numerous therapeutic insects in the future, more research is necessary.
Heavenly Healing of Disability and the Problem of Preserving Identity through Radical Change
Authors: Gould James B. ,   Philosophy Documentation Center
Published: April 2023

The traditional elimination view affirms that people with intellectual disabilities will be healed in heaven when God restores all things to what they were meant to be. Several contemporary scholars, however, have put forth a revisionist retention view claiming that people with intellectual disabilities will not be healed in heaven. While the elimination view has strong biblical and theological credentials, it faces a significant philosophical difficulty. Heaven must maintain identity so that individuals exist as the same people they were in life. But post-mortem healing appears to disrupt the identity of people with intellectual disabilities. In this paper I reject this charge. I argue that for individuals with mild or moderate intellectual disabilities heaven preserves personal identity, while for individuals with profound intellectual disabilities heaven creates personal identity. These conclusions rest on an emergentist anthropology which I describe.
Mixed linear model for investigating food security during the covid-19 pandemic: Panel data for rice consumption in indonesia
Authors: Aisyah Mutiara Aghnyn , Putri Devita Amalia , Chandra Yoshua , Syazali Muhamad , Machmud Amir , Rachmawati Ro'fah Nur
Published: April 2023

The Covid-19 pandemic has affected human life behavior, starting from health, the economy to living habits, one of them is the rice consumption. This study aims to find out whether the Covid-19 pandemic can affect people's rice consumption, and what are the factors that can affect people's rice consumption before and during the pandemic. The independent factors studied in this study were harvested area, productivity, rice production, crime rate, and the ratio of household gas use, with rice consumption as the dependent variable. The data used is panel data for 2019 and 2020, from 34 provinces in Indonesia, which is one of the five countries with the highest rice consumption in the world. By using mixed linear models, the research results show that in general Covid-19 pandemic has not had a significant effect on rice consumption in Indonesia. Other facts also show that social factors, namely the crime rate during a pandemic, did not have a significant effect on rice consumption.However, this is different from economic factors such as productivity and harvested area which have a significant positive effect on rice consumption in Indonesia.
Antimicrobial Susceptibility Pattern of Klebsiella pneumoniae Isolated from Various Clinical Specimens in Ujjain City, Madhya Pradesh, India
Authors: Maity Soumendra N. , Marothi Yogyata , Pradhan Riddhi , Waske Sonali , Hemwani Kirti
Published: April 2023

Klebsiella pneumoniae is an important opportunistic pathogen that commonly causes nosocomial infections and contributes to substantial morbidity and mortality. We sought to investigate the sensitivity pattern of K. pneumoniae isolated from various clinical specimens. Methods- This cross-sectional study was conducted at Ruxmaniben Deepchand Gardi Medical College and Ujjain Charitable Trust Hospital in Ujjain City during March 2021 to September 2021 on total 463culture positive isolates from various clinical specimens. Identification of K. pneumoniae and antibiogram testing were performed by using VITEK-2 compact bacterial identification and monitoring system (bioMerieux, US). The data were analyzed by using NCSS statistical software 2021. Results- In total, 83 positive K. pneumoniae cultures from various clinical samples were examined. The isolates were more predominant in the females (n = 45; 54.2%) compared to males (n = 38; 45.8%). The antibiotic resistance rate of K. pneumoniae varied among different isolate clinical sample sources. Overall, high resistance rates were recorded for ampicillin (100%), amoxyclav (81.48%),  piperacillin/ tazobactam (73.68%), cefuroxime (94.74%), ceftriaxone (91.2%), cefotaxime (91.2%),  and cefepime (73.68%). A total of 83 K. pneumoniae isolates, 75 were ESBL (90.36%) producers. However, colistin (100%) showed the highest susceptibility rate against the isolates. Conclusion- the wide variety of MDR K. pneumoniae harboring β-lactams and virulence genes strongly suggest a necessity for the implementation of effective strategies to prevent and control the spread of antibiotic resistant infections.
Isolated Skull Metastasis as first presentation of possible primary from Lung
Authors: Jain Kavita , Surana Akshay , Dubey Ashish , Nandedkar Shirish
Published: April 2023

Skull or scalp metastasis is commonly seen in carcinoma of breast, prostate, kidneys and lungs. Here we report a case of 80-year-old male who presented with scalp swelling for treatment. High resonance ultrasonography (HRUS) and contrast-enhanced computed tomography (CECT) of brain showed large soft tissue lesion on right occipito-parietal region with erosion of underlying bone, suggestive of neoplastic etiology. Subsequently, on further workup, his CT thorax showed lesion in right hilar and lower lobe of right lung with mediastinal lymph nodes. Patient underwent excision of the right occipito-parietal lesion which on histopathology was reported as epithelial malignancy, favoring metastatic moderately differentiated squamous cell carcinoma. This case is reported here to emphasize the importance of good clinical workup to rule out metastatic lesions which might be the initial presentation of an unknown primary at other site.
A Case of Mixed Connective Tissue Disorder in a Young Female
Authors: P. Tripathi Ajay , Yadav Amit , Sharma Ashish , Patidar Vimlesh , Bamboriya B. L. , Jain Himanshu , Adhikari Ajay
Published: April 2023

We present a case of Mixed connective tissue disorder presented in our institute. Mixed connective tissue disease (MCTD), a rare entity in rheumatology.
Self-Reliance is the best strategy for development
Authors: Diwan Vinod
Published: April 2023

In public health, prevention or a disease is better than cure. This principle is applicable in many aspects of life. However, in recent years, clinical medicine has emphasized cure more than prevention. Power and use of power has something to do with this. Often doctors and other healthcare workers consider the population and patients as ignorant. When a patient question or suggests something related to her/his disease, symptoms or body, often "are you a doctor or I am a doctor" is heard from today's doctors. This attitude in healthcare is prevalent and not limited to doctors. Even nurses could be heard to show such arrogance. This must change. A person knows more about his or her body, how they feel than anyone else, including doctors. The saying "whose body is this" must be respected. Doctors must listen to what the patient is saying and take actions to empower the patient.
ANALISIS PENGARUH PERCEIVED VALUE TERHADAP LOYALITAS PELANGGAN DENGAN KEPUASAN KONSUMEN SEBAGAI VARIABEL INTERVENING DITINJAU DARI MANAJEMEN BISNIS SYARIAH (Studi Pada Pengguna Scarlet di Bandar Lampung)
Authors: Yulistia Devi  , Saefurrohman Ghina Ulfah , Ermawati Liya , Ningsih Nurwahyu
Published: April 2023

Produk skincare yang ada di Indonesia, Scarlet berada pada posisi pertama dengan pangsa pasar yang diraih  jauh lebih tinggi dari merek lain, yaitu 18.9%. Nilai persepsi (perceived value) yang tinggi akan menghasilkan kepuasan pelanggan yang tinggi. Sebagaimana diketahui bahwa tujuan dari suatu bisnis adalah untuk menciptakan para pelanggan merasa puas. Terciptanya kepuasaan dapat memberikan beberapa manfaat, diantaranya hubungan antara perusahaan dengan pelanggannya menjadi harmonis sehingga memberikan dasar yang baik bagi pembelian ulang. Penelitian ini menggunakan analisis data kuantitatif. Pemilihan sampel menggunakan teknik probability sampling dengan total sampel berjumlah 100 sampel. Data diolah menggunakan alat bantu program IBM SPSS versi 25. Uji analisis data yang digunakan yaitu uji instrument penelitian (validitas dan reliabilitas), uji asumsi klasik (Normalitas, multikolinearitas, dan heteroskedastisitas),  uji t, uji f,  dan uji sobel test. Pengujian hipotesis penelitian dilakukan dengan menggunakan model analisis jalur (path analysis). Hasil penelitian menunjukan bahwa : (1) perceived value memiliki pengaruh yang signifikan terhadap loyalitas. (2) perceived value mempunyai pengaruh yang signifikan terhadap kepuasan pelanggan. (3) kepuasan mempunyai pengaruh dan signifikan terhadap Loyalitas pelanggan . (4) Kepuasan konsumen memediasi hubungan antara perceived value terhadap loyalitas konsumen pada pengguna scarlet.
Pengaruh Pengangguran dan Pertumbuhan Ekonomi Terhadap Indeks Pembangunan Manusia
Authors: Susilowati Dados , Adianita Happy
Published: April 2023

This study aims to determine the effect of unemployment and economic growth on the Human Development Index in Bojonegoro. The research design used is associative descriptive quantitative. The data source for this research is secondary data in the form of data tables for 2006 – 2020 obtained from the Bojonegoro Central Bureau of Statistics (BPS). The technique of determining the sample using the judgment sampling method. The study shows that the variables of unemployment and economic growth simultaneously have a positive and significant influence on the Human Development Index. While partially, the unemployment variable has a negative and insignificant effect and the economic growth variable has a positive and significant influence on the Human Development Index. From the results of the two independent variables, the variable economic growth is the most dominant variable influencing the Bojonegoro Regency Human Development Index with the largest regression coefficient value.
Penelitian ini membahas mengenai pengaruh Pengangguran dan Pertumbuhan Ekonomi terhadap Indeks Pembangunan Manusia kabupaten Bojonegoro tahun 2006-2020. Tingkat pengangguran Kabupaten Bojonegoro selalu mengalami fluktuasi dari tahun ke tahun. Terhitung dari tahun 2006 sampai dengan 2020 tingkat pengangguran Kabupaten Bojonegoro tertinggi terdapat pada tahun 2006 sebesar 10,02%. Dampak buruk yang dapat ditimbulkan oleh pengangguran yaitu berkurangnya pendapatan dalam masyarakat. Pengangguran dan Pertumbuhan ekonomi secara bersama – sama mempengaruhi Indeks Pembangunan Manusia Kabupaten Bojonegoro tahun 2006-2020. Variabel bebas yaitu Pengangguran dan Pertumbuhan Ekonomi hanya mampu mempengaruhi variabel terikat yaitu Indeks Pembangunan Manusia Kabupaten Bojonegoro  sebesar  50,51%  sedangkan  sisanya  49,49%  dipengaruhi  variabel diluar penelitian. Berdasarkan hasil regresi dapat dijelaskan bahwa variabel Pertumbuhan Ekonomi merupakan variabel dominan dalam mempengaruhi Indeks Pembangunan  Manusia  Kabupaten  Bojonegoro  tahun 2006-2020. Hal  tersebut sesuai dengan hipotesis penelitian yang menyatakan Pertumbuhan Ekonomi berpengaruh dominan terhadap Indeks Pembangunan Manusia Kabupaten Bojonegoro tahun 2006-2020.
Peran Pemerintah Pusat dan Daerah dalam Menyediakan Pendidikan Dasar Bermutu untuk Mewujudkan Visi Indonesia 2045
Authors:   Dinas Pendidikan dan Kebudayaan Kabupaten Bangka Selatan, Indonesia, Sui-Ni Ngan
Published: April 2023

A sovereign, advanced, just, and prosperous Indonesia has been designated as the Vision of Indonesia 2045. A vision that encapsulates the great goals of a country in positioning itself both in an internal and external context as part of world civilization. This vision is at the same time a reference as well as a basis in the development of human resources (HR) to support its realization. The division of educational affairs between the Central Government and Regional Governments is a challenge to creating quality human resources. The Central Government on the one hand has the authority as a regulator of the standardization of the national education system. Regional Governments on the other hand want an education system that accommodates the needs, uniqueness, and advantages of their region. Then what is the role of both in the provision of quality education? What are the challenges that must be faced? This literature study will explore the feasibility dimension in the quality of education, as well as the role of the Central and Regional Governments in providing quality education to realize the Vision of Indonesia 2045.
PERCEPTIONS OF WINE HEALTH BENEFITS AND EFFECTS OF WINE CONSUMPTION ON WELL-BEING
Authors: Ilak Peršurić Anita Silvana , Rossi Sara , Bestulić Ena , Radeka Sanja
Published: April 2023

The purpose of the survey was to identify and analyze moderate wine consumption of Croatian autochthonous wine varieties. The survey was conducted in 2019 and 2020 on the Croatian Science Foundation scientific project “Vinum Sanum”. Dimensions of wine and health benefits, wine quality, labelling, positive and negative effects on wine labels and psychological well-being were assessed with a questionnaire from 374 participants. Results indicated that wine was perceived as a healthy beverage, consumed as part of healthy life style. Health benefits were perceived positively through cardiac, physical health and psychological well-being. Most important quality features were: origin; micro region, terroir, PGI/PDO (protected geographic origin/protected designation of origin), vintage, ageing and sugar content. This survey might be used as scientific evidence for developing health claims for wine, for producers to use health enhancing properties of wines and create packages and/or labels which may boost the positive perception of wine health benefits.
An Empirical Study on Determinants of Price Earnings Ratio: Evidence from Listed Food, Beverage and Tobacco Companies in Colombo Stock Exchange
Authors: Sajeetha Abdul Majeed Fathima , Nusaika Manartheen Fathima , Safana Muhammed Najeeb Fathima Nusrath
Published: April 2023

The Price earnings ratio compares a stock’s price to earnings. By showing the relationship between a company’s stock price and earnings per share (EPS), the Price earnings ratio helps investors to value a stock and gauge market expectations. The ratio is affected by several factors that are responsible for the variations of Price earnings ratio. These variations of Price earnings ratio have significant impact on investor’s perception. This paper attempts to identify the factors and the relationships between the factors and Price earnings ratio of food, beverage, and tobacco companies in Colombo Stock Exchange (CSE). Based on simple sampling, data were taken for this purpose from annual reports of 30 food, beverage, and tobacco companies listed on the CSE for the five-year period from 2015 to 2019. The study focuses on secondary data collected through the published annual reports of the sample. Descriptive statistics, correlation analysis and multiple regression analysis are used to accomplish the objective of this paper. Results revealed that dividend payout ratio and leverage ratio are significant determinants of Price earnings ratio where these both variables have positive influence on Price earnings ratio. Furthermore, return on equity and earnings per share are negative insignificant determinants of Price earnings ratio. Dividend payout ratio and leverage ratio have positive correlation with price earnings ratio. It can be statistically concluded that dividend payout ratio and leverage ratio have positive significant relationship with price earnings ratio. Return on equity and earnings per share have negative correlation with price earnings ratio. Significant values are higher than the test alpha values. Therefore, the researcher can reject the alternative hypothesis. It can be statistically concluded that return on equity and earnings per share have negative insignificant relationship with price earnings ratio. This paper is evidence for fundamental analysts and decision makers to evaluate determinants that explain variations in P/E ratio of food, beverage, and tobacco companies in Sri Lanka.
Comparative Evaluation of the Effects of Pre-Sowing Treatments on the Germination and Growth Parameters of Abelmoschus esculenta Linn.
Authors: Okereke Chukwu Nkumah , Ikegbunam Clara Nchedochukwu , Nwaogaranya Uche Patrick , Ogbu Angela Chinenye , Francis Ozibo Amobi , Iroka Chisom Finian
Published: April 2023

A comparative study on the effects of pre-sowing treatments on the germination and growth of Abelmoschus esculentus was done by putting the seeds through three treatments at different durations before sowing. These treatments involved soaking the seeds in 30% H2SO4, vernalization and soaking in water (hydrotreatment). Five polyethene bags were used for each replicate, 16 replicates of 10kg of soil were prepared for the plant according to the treatments and duration placement. Morphometric data such as germination percentage, plant height, stem girth and leaf area were collected and analyzed using mean, variance, standard deviation, variance of the mean, standard error and confidence limit. The results of the analysis showed the various treatments and the duration significance on percentage germination and growth parameters of Abelmoschus esculentus seeds. Data showed the effects of various treatments duration and their significance on percentage germination of Abelmoschus esculentus seeds. The result further showed that the treatment of seeds before cultivation increased the percentage germination in A. esculentus when compared with the control replicate. It was also revealed that the height readings of different treatment sources and treatment durations did significantly affect the height of A. esculentus. It was also observed that leaf Area and stem girth significantly increased in different treatment methods and durations as seen in treatment of A. esculentus respectively. This research showed that seed treatment resulted in early germination and high growth rate; hence seed treatment with either soaking in 30% sulphuric acid, vernalization or soaking in water should be used for enhancing emergence and better seedling growth in Abelmoschus esculentus but attention should be paid to the duration of exposure of seed to these treatments.
Innovation and Entrepreneurship in Collaborative Education in Colleges and Universities
Authors: Lu Huidi , Chen Fengdie , Song Xiaona
Published: April 2023

It is important to introduce the concept of "collaborative education" into innovation and entrepreneurship education in colleges and universities and establish a relatively perfect system for the integration of all forces and the realization of complementary advantages. This article aims to analyse university innovation entrepreneurship education collaborative education mechanism construction as main issue. To further investigate the actual situation of the current innovation in colleges and universities, to understand the effect of the implementation of the overall collaborative education mechanism, to explore the fundamental problems existing in the process of education, based on the dilemma of the university innovation entrepreneurship education, deep exploration and innovation construction system unique innovation entrepreneurship education mode and collaborative education mechanism. Innovation and entrepreneurship education are the keys to reach for success in the current international market struggling, and it is also the biggest driving force for the establishment of an innovation-oriented country and sustained economic growth. The introduction of innovation and entrepreneurship in the university stage can make students more fully understand how innovation and entrepreneurship stimulate students’ awareness of innovation, and reduce the unemployment rate of college students. At the same time, it showed positive significance on temper students' will and the process in shaping their good conduct.
Thermophobic Trehalose Glycopolymers as Smart C‐Type Lectin Receptor Vaccine Adjuvants
Authors: Hendricksen Aaron T. , Ezzatpour Shahrzad , Pulukuri Anunay J. , Ryan Austin T. , Flanagan Tatum J. , Frantz William , Buchholz David W. , Ortega Victoria , Monreal Isaac A. , Sahler Julie M. , Nielsen Amy E. , Aguilar Hector C. , Mancini Rock J.
Published: April 2023

Herein, this work reports the first synthetic vaccine adjuvants that attenuate potency in response to small, 1–2 °C changes in temperature about their lower critical solution temperature (LCST). Adjuvant additives significantly increase vaccine efficacy. However, adjuvants also cause inflammatory side effects, such as pyrexia, which currently limits their use. To address this, a thermophobic vaccine adjuvant engineered to attenuate potency at temperatures correlating to pyrexia is created. Thermophobic adjuvants are synthesized by combining a rationally designed trehalose glycolipid vaccine adjuvant with thermoresponsive poly‐N‐isoporpylacrylamide (NIPAM) via reversible addition fragmentation chain transfer (RAFT) polymerization. The resulting thermophobic adjuvants exhibit LCSTs near 37 °C, and self‐assembled into nanoparticles with temperature‐dependent sizes (90–270 nm). Thermophobic adjuvants activate HEK‐mMINCLE and other innate immune cell lines as well as primary mouse bone marrow derived dendritic cells (BMDCs) and bone marrow derived macrophages (BMDMs). Inflammatory cytokine production is attenuated under conditions mimicking pyrexia (above the LCST) relative to homeostasis (37 °C) or below the LCST. This thermophobic behavior correlated with decreased adjuvant Rg is observed by DLS, as well as glycolipid‐NIPAM shielding interactions are observed by NOESY‐NMR. In vivo, thermophobic adjuvants enhance efficacy of a whole inactivated influenza A/California/04/2009 virus vaccine, by increasing neutralizing antibody titers and CD4+/44+/62L+ lung and lymph node central memory T cells, as well as providing better protection from morbidity after viral challenge relative to unadjuvanted control vaccine. Together, these results demonstrate the first adjuvants with potency regulated by temperature. This work envisions that with further investigation, this approach can enhance vaccine efficacy while maintaining safety.
Antisense Oligonucleotides Selectively Enter Human‐Derived Antibiotic‐Resistant Bacteria through Bacterial‐Specific ATP‐Binding Cassette Sugar Transporter
Authors: Liu Mingzhu , Chu Binbin , Sun Rong , Ding Jiali , Ye Han , Yang Yunmin , Wu Yuqi , Shi Haoliang , Song Bin , He Yao , Wang Houyu , Hong Jiaxu
Published: April 2023

Current vehicles used to deliver antisense oligonucleotides (ASOs) cannot distinguish between bacterial and mammalian cells, greatly hindering the preclinical or clinical treatment of bacterial infections, especially those caused by antibiotic‐resistant bacteria. Herein, bacteria‐specific ATP‐binding cassette (ABC) sugar transporters are leveraged to selectively internalize ASOs by hitchhiking them on α (1–4)‐glucosidically linked glucose polymers. Compared with their cell‐penetrating peptide counterparts, which are non‐specifically engulfed by mammalian and bacterial cells, the presented therapeutics consisting of glucose polymer and antisense peptide nucleic‐acid‐modified nanoparticles are selectively internalized into the human‐derived multidrug‐resistant Escherichia coli and methicillin‐resistant Staphylococcus aureus, and they display a much higher uptake rate (i.e., 51.6%). The developed strategy allows specific and efficient killing of nearly 100% of the antibiotic‐resistant bacteria. Its significant curative efficacy against bacterial keratitis and endophthalmitis is also shown. This strategy will expand the focus of antisense technology to include bacterial cells other than mammalian cells.
DARPP‐32 cells and neuropil define striosomal system and isolated matrix cells in human striatum
Authors: Arasaratnam Christine J. , Song Jennifer J. , Yoshida Tomoko , Curtis Maurice A. , Graybiel Ann M. , Faull Richard L. M. , Waldvogel Henry J.
Published: April 2023

The dorsal striatum forms a central node of the basal ganglia interconnecting the neocortex and thalamus with circuits modulating mood and movement. Striatal projection neurons (SPNs) include relatively intermixed populations expressing D1‐type or D2‐type dopamine receptors (dSPNs and iSPNs) that give rise to the direct (D1) and indirect (D2) output systems of the basal ganglia. Overlaid on this organization is a compartmental organization, in which a labyrinthine system of striosomes made up of sequestered SPNs is embedded within the larger striatal matrix. Striosomal SPNs also include D1‐SPNs and D2‐SPNs, but they can be distinguished from matrix SPNs by many neurochemical markers. In the rodent striatum the key signaling molecule, DARPP‐32, is a exception to these compartmental expression patterns, thought to befit its functions through opposite actions in both D1‐ and D2‐expressing SPNs. We demonstrate here, however, that in the dorsal human striatum, DARPP‐32 is concentrated in the neuropil and SPNs of striosomes, especially in the caudate nucleus and dorsomedial putamen, relative to the matrix neuropil in these regions. The generally DARPP‐32‐poor matrix contains scattered DARPP‐32‐positive cells. DARPP‐32 cell bodies in both compartments proved negative for conventional intraneuronal markers. These findings raise the potential for specialized DARPP‐32 expression in the human striosomal system and in a set of DARPP‐32‐positive neurons in the matrix. If DARPP‐32 immunohistochemical positivity predicts differential functional DARPP‐32 activity, then the distributions demonstrated here could render striosomes and dispersed matrix cells susceptible to differential signaling through cAMP and other signaling systems in health and disease.

DARPP‐32 is highly concentrated in cells and neuropil of striosomes in post‐mortem human brain tissue, particularly in the dorsal caudate nucleus.

Scattered DARPP‐32‐positive cells are found in the human striatal matrix.

Calbindin and DARPP‐32 do not colocalize within every spiny projection neuron in the dorsal human caudate nucleus.
How does solid‐state drives cluster perform for distributed file systems: An empirical study
Authors: Wu Jiashu , Wang Yang , Wang Jinpeng , Wang Hekang , Lin Taorui
Published: April 2023

As the capacity of Solid‐State Drives (SSDs) is constantly being optimised and boosted with gradually reduced cost, the SSD cluster is now widely deployed as part of the hybrid storage system in various scenarios such as cloud computing and big data processing. However, despite its rapid developments, the performance of the SSD cluster remains largely under‐investigated, leaving its sub‐optimal applications in reality. To address this issue, in this paper we conduct extensive empirical studies for a comprehensive understanding of the SSD cluster in diverse settings. To this end, we configure a real SSD cluster and gather the generated trace data based on some often‐used benchmarks, then adopt analytical methods to analyse the performance of the SSD cluster with different configurations. In particular, regression models are built to provide better performance predictability under broader configurations, and the correlations between influential factors and performance metrics with respect to different numbers of nodes are investigated, which reveal the high scalability of the SSD cluster. Additionally, the cluster's network bandwidth is inspected to explain the performance bottleneck. Finally, the knowledge gained is summarised to benefit the SSD cluster deployment in practice.
Identification of unique α4 chain structure and conserved antiangiogenic activity of α3NC1 type IV collagen in zebrafish
Authors: LeBleu Valerie S. , Dai Jianli , Tsutakawa Susan , MacDonald Brian A. , Alge Joseph L. , Sund Malin , Xie Liang , Sugimoto Hikaru , Tainer John , Zon Leonard I. , Kalluri Raghu
Published: April 2023

Background

Type IV collagen is an abundant component of basement membranes in all multicellular species and is essential for the extracellular scaffold supporting tissue architecture and function. Lower organisms typically have two type IV collagen genes, encoding α1 and α2 chains, in contrast with the six genes in humans, encoding α1–α6 chains. The α chains assemble into trimeric protomers, the building blocks of the type IV collagen network. The detailed evolutionary conservation of type IV collagen network remains to be studied.

Results

We report on the molecular evolution of type IV collagen genes. The zebrafish α4 non‐collagenous (NC1) domain, in contrast with its human ortholog, contains an additional cysteine residue and lacks the M93 and K211 residues involved in sulfilimine bond formation between adjacent protomers. This may alter α4 chain interactions with other α chains, as supported by temporal and anatomic expression patterns of collagen IV chains during the zebrafish development. Despite the divergence between zebrafish and human α3 NC1 domain (endogenous angiogenesis inhibitor, Tumstatin), the zebrafish α3 NC1 domain exhibits conserved antiangiogenic activity in human endothelial cells.

Conclusions

Our work supports type IV collagen is largely conserved between zebrafish and humans, with a possible difference involving the α4 chain.