bluuebunny/crossref_metadata_2025 huggingface dataset:
Methodological Considerations in Studying Transformational Leadership and its Outcomes
Authors: Zefeiti Salim Musabah Bakhit Al , Mohamad Noor Azmi
Published: April 2015

The current paper aims to discuss the methodology of developing a social-structure explanation of employee work performance, emphasizing the importance of transformational leadership behaviours and the three components of organizational commitment in an Arab context. As this research paper adopted the pragmatist view in exploring the phenomenon, choices of lower-level methodological considerations are influenced by such philosophical perspective. The cross-section ‘snapshot’ descriptive questionnaire survey was considered as the most appropriate research approach to gather information. Statistical techniques were proposed as the means to analyse the data.
A Microfluidic Platform Containing Sidewall Microgrooves for Cell Positioning and Trapping
Authors: Khabiry Masoud , Jalili Nader
Published: April 2015

Microfluidic channels enable the control of cell positioning and the capturing of cells for high-throughput screening and other cellular applications. In this paper, a simple microfluidic platform is proposed for capturing small volumes of cells using sidewall microgrooves. The cell docking patterns in the channels containing sidewall microgroove are also studied. Both numerical and experimental investigations are performed within channels containing sidewall microgrooves of three different widths (i.e., 50, 100 and 200 μm). It is observed that channels containing sidewall microgrooves play an important role in regulating cell positioning and patterning. The obtained results revealed that 10 to 14 cells were positioned inside the sidewall channels of 200 μm width, two to five cells were positioned within the channels of 100 μm width, and one to two individual cells were docked within the sidewall channel of 50 μm width. Particle modelling shows the prediction of cell positioning within sidewall microgrooves. The positions of cells docked within microgroove-containing channels were also quantified. Furthermore, the shear stress variation and cell positioning in the sidewall microgrooves were correlated. Therefore, these sidewall microgroove-containing channels could be potentially useful for regulating cell positioning and patterning on two-dimensional surfaces, three-dimensional microenvironments and high-throughput screening. Cell patterning and positioning are of great importance in many biological applications, such as drug screening and cell-based biosensing.
Why Do Conservatives Report Being Happier Than Liberals? The Contribution of Neuroticism
Authors: Burton Caitlin M. , Plaks Jason E. , Peterson Jordan B.
Published: April 2015

Previous studies suggest that conservatives in the United States are happier than liberals. This difference has been attributed to factors including differences in socioeconomic status, group memberships, and system-justifying beliefs. We suggest that differences between liberals and conservatives in personality traits may provide an additional account for the "happiness gap". Specifically, we investigated the role of neuroticism (or conversely, emotional stability) in explaining the conservative-liberal happiness gap. In Study 1 (N = 619), we assessed the correlation between political orientation (PO) and satisfaction with life (SWL), controlling for the Big Five traits, religiosity, income, and demographic variables. Neuroticism, conscientiousness, and religiosity each accounted for the PO-SWL correlation. In Study 2 (N = 700), neuroticism, system justification beliefs, conscientiousness, and income each accounted for PO-SWL correlation. In both studies, neuroticism negatively correlated with conservatism. We suggest that individual differences in neuroticism represent a previously under-examined contributor to the SWL disparity between conservatives and liberals.
Clinical Test of Pyrroles in Psychiatric Disorders: Association with Nutritional, Immunological and Metabolic Markers
Authors: Mikirova Nina
Published: April 2015

Background: Psychiatrists started using urine pyrroles (hydroxyhemopyrrolin-2-one, HPL) to diagnose psychiatric disorders many years ago. The biological origins of HPL are not known, nor are the causes of elevated urinary pyrrole excretion well understood.
Methods: In the present study we analyzed the level of pyrroles in 148 patients with schizophrenia, 135 patients with bipolar disorder, 97 patients with depression, 119 patients with ADHD and compared these data with the results of pyrrole tests for patients with non-psychiatric conditions and healthy volunteers.
Results: According to our data, urinary pyrrole concentrations tended to be high in patients with psychiatric disorders, but elevated level of pyrroles was not specific for only these patients. We found evidence of an allergy related component in the fact that elevated pyrrole levels were significantly more prevalent in subjects with elevated histamine values. A role of intestinal bacteria, or imbalances in intestinal bacterial metabolism, was also suggested based on the found relationship between elevated pyrrole levels and elevations in indicans and urobilinogens. In addition, our data demonstrated that subjects with severely elevated pyrrole levels were deficient in nutrients such as zinc, vitamin B3, and vitamin C.
Conclusion: Thus, pyrrole excretion seems to be a component of illness in general and not strictly psychiatric disorders.
A Review on Metabolic Syndrome and Nutrition
Authors: Mesçi Banu , Erbakan Ayse , Çaklili Özge Telci
Published: April 2015

Metabolic syndrome can be defined as a disorder with occurrence of at least three out of five medical conditions including hyperglycemia, hypertriglyceridemia, high blood pressure, central obesity and low HDL cholesterol levels. In this review we will discuss how to improve poor eating habits which further escalates the risk of cardiovascular disease and diabetes. To treat and moreover to prevent metabolic syndrome, we should make healthy life style changes as our priority goal. Macro and micronutrient composition and metabolically favorable food components have a profound influence on health outcomes. Though Mediterranean and DASH diets are referred as the healthiest diets, there are numerous diets that are as well successful. Positive effects of low carbohydrate diets on glycemic regulation have been shown. Nonetheless, personalized nutrition applications with persistent implementation of these changes are foundations for success. A successful approach also needs regular exercise and behavioral changes.
Uso da Membrana de Oxigenação Extracorpórea em uma Paciente Pós-Transplante Pulmonar: Cuidados de Enfermagem
Authors: Bertacchini de Oliveira Larissa , Domingues Neves Ana Lucia , Jardim Jaquelline Maria , De Brito Nunes Mendes Priscilla , Crivelari Naves Sara , Bruno Tatiana Cristina , Alves de Araújo Püschel Vilanice , Baldacin Rodrigues Adriano Rogério , Dos Santos Lima Zilda
Published: April 2015

Se trata de un relato de experiencia de un caso sin precedentes en Brasil acerca de la sistematización de los cuidados de enfermería aplicados a una paciente en asistencia circulatoria mecánica con membrana de oxigenación extracorpórea en el postoperatorio de un trasplante de pulmón. Se establecieron 18 diagnósticos de enfermería y las 94 conductas implementados abarcaron: cuidados con el circuito de asistencia, monitorización hemodinámica y control de las pruebas de laboratorio. Los principales resultados fueron que el paciente presentaba: un mejor intercambio de gases, mantenimiento de la estabilidad hemodinámica y ausencia de efectos adversos relacionados con el tratamiento, como el sangrado y reducción de la perfusión de la extremidad de la cánula venosa. La sistematización de la atención establecida mostró agregar conocimiento científico, orientación a la práctica clínica y atención integral.
O enfermeiro que atua em unidades hospitalares oncológicas: perfil e capacitação profissional
Authors: Santos Fabiana Cristina , Camelo Silvia Helena Enriques , Laus Ana Maria , Leal Laura Andrian
Published: April 2015

Este es un estudio que tuvo como objetivo identificar el perfil de la enfermera que trabaja en las unidades hospitalarias de oncología.

Se trata de una revisión integradora y la recolección de datos se llevó a cabo en cuatro bases de datos electrónicas en el período de marzo a mayo de 2013. Se seleccionaron 15 artículos publicados en el período 2004-2013.

Los resultados se describen en dos categorías: 1. El perfil social y profesional de las enfermeras que trabajan en unidades hospitalarias de oncología y 2. Formación y preparación de la enfermera para actuar en unidades hospitalarias de oncología. Las enfermeras son mujeres, con edades comprendidas entre 23 y 57 años de experiencia en el campo, con la preparación académica suficiente para la graduación. Identifica la necesidad de un desarrollo científico y técnico profesional a través de la especialización, de postgrado, residencias, capacitación, cursos de actualización y la participación en conferencias.

El estudio deberá aumentar la conciencia de las enfermeras y administradores de servicios de salud como el perfil y la preparación adecuada de los que trabajan en las unidades de oncología hospitalaria.
Internet y conducta sexual de riesgo para VIH/SIDA en jóvenes
Authors: Valdez Montero Carolina , Benavides Torres Raquel Alicia , González y González Víctor , Onofre Rodríguez Dora Julia , Castillo Arcos Lubia
Published: April 2015

Objetivo: Determinar si el uso de material sexual en línea influye en la conducta sexual de riesgo para VIH/SIDA en los jóvenes universitarios. Se utilizaron conceptos de la Teoría Cognitiva Social.
Método: Diseño descriptivo correlacional, participaron 200 jóvenes universitarios, seleccionados por muestreo aleatorio sistemático (k = 11).
Resultados: Los jóvenes que usaron material sexual en línea en medios ricos para masturbarse (rs = .34), excitarse (rs = .29), estimularse (rs = .29), buscar una aventura (rs = .30), conocer gente (rs = .27), imágenes (rs = .14) y cibersexo (rs = .25) mostraron mayor conducta sexual de riesgo para VIH/SIDA (p < .01). El uso de material sexual en línea para masturbarse (R2 = 6.4%, F [1,189] = 12.80, p < .001), buscar una aventura (R2 = 4.8%, F [1,189] = 9.56, p < .01), conocer gente (R2 = 5.9%, F [1,189] = 11.88, p < .01) y tener cibersexo (R2 = 4.1%, F [1,189] = 8.07, p < .01) presentó un efecto positivo y significativo en la conducta sexual de riesgo para VIH/SIDA.
Conclusiones: El uso de material sexual en línea influye en la conducta sexual de riesgo para VIH/SIDA.
Entornos educativos saludables de los estudiantes universitarios de enfermería
Authors: Gomez Patricia Fabiana , Cometto María Cristina , Cerino Sandra
Published: April 2015

Introducción: La presente investigación tuvo como objetivo determinar los entornos de estudio y aprendizaje que poseen los estudiantes de enfermería de la Universidad Nacional de Córdoba.
Material y método: Estudio observacional-analítico, período 2011. Universo, estudiantes que cursan la licenciatura. Muestra estratificada, aleatoria. Técnica encuesta auto administrada. Fuente primaria.
Resultados: La población estuvo compuesta por 290 alumnos, el 46% poseen entre 18 y 25 años, el 44% entre 26 y 40; 83% mujeres; 68% solteros; el 76% convive con la familia, y el 69% posee familiares a cargo; el 56% trabaja y el 44% recibe ayuda de los padres o beca.
Al analizar el entorno en la dimensión organización y gestión, en la facilitación de materiales, se destaca su disponibilidad en más del 70%. En la planta física el 50% respondieron que no es adecuada. Los alumnos reciben apoyo en sus distintas variantes pedagógicas un 75%. En la planificación de cátedras el 78% que no existe. El 52% respondió que la conducción en el período estudiado no demuestra habilidad para la gestión. Con respecto al aspecto vincular académico los estudiantes no se sienten escuchados en la institución en un 65%, respondiendo que la comunicación entre pares es poco o medianamente colaborativa en un 59%. El 78% de los estudiantes afirman que no existe comunicación entre los dos ciclos. Por último a la dimensión de la participación estudiantil en relación al centro de estudiantes el 92% respondieron que no participan activamente y el 59% afirman que no promueve un entorno saludable.
Conclusión: La organización y gestión, y la comunicación son identificadas negativamente. Consideramos que resta diseñar elementos que visibilicen esta problemática como central en la política de gestión académica, para construir estrategias conjuntas de resolución.
Use of non-steroidal anti-inflammatory drugs and nutritional supplements in Zimbabwean football
Authors: Mkumbuzi N S
Published: April 2015

Background. The use of medications by football players in many populations is known to be high. Data on African players are scarce. Objective. To determine the magnitude of use of non-steroidal anti-inflammatory drugs (NSAIDs) and nutritional supplements by Zimbabwean football players. Methods. We conducted a cross-sectional study during the 2011/2012 Premier Soccer League football season. A total of 86 players responded to a self-administered questionnaire that assessed self-reported use of NSAIDs and nutritional supplements. Results. All the participants admitted to taking NSAIDs, with 44% self-prescribing. Nutritional supplements were taken by 56% of the respondents. Of these, 21% took them on a daily basis and 40% did so without professional advice. Conclusion. Regular, self-prescribed use of NSAIDs and nutritional supplements is high among Zimbabwean football players.
Primary spontaneous pneumothorax in a recreational athlete
Authors: Van der Colff F J
Published: April 2015

Primary spontaneous pneumothorax (PSP) is relatively uncommon in the athletic population. Because of the subtle nature of the symptoms, the diagnosis is easily missed, which can lead to unnecessary prolonged discomfort and recovery time for the athlete. ere is currently a lack of evidence in the literature concerning treatment and return-to-play protocols referring specically to PSP within the athletic community. is case report highlights the predisposing and important factors in the history of a 34-year-old recreational male athlete who developed PSP. According to the knowledge of the authors, this report of PSP in a recreational athlete is the rst of its kind described in South Africa. Owing to the possibility of life-threatening complications, it is important for sports physicians to be familiar with the important points in the history and to be made aware of the predisposing factors that may lead to PSP.
Pour un imaginaire grand parisien
Authors: Robin Régine
Published: April 2015

La place de Paris dans l’imaginaire collectif hexagonal et international est énorme. L’étude décrit la naissance et l’évolution de la représentation enchantée de la capitale française, capitale du romantisme à laquelle la littérature, le cinéma, la chanson, l’art en général ont donné une aura qui s’est étendue sur le long XXe siècle et jusqu’à nos jours. Mais dans les temps récents, le dynamisme de cette célébration symbolique s’est atténué, comme s’il y avait eu un trop-plein de chromos et une usure progressive des signes. Cette érosion et cette surabondance ont engendré des clichés et des stéréotypes indéfiniment reconduits et ressassés. Après avoir dressé ce constat et montré comment se construit ce Paris « carte postale » dont  Midnight in Paris  de Woody Allen fournit un exemple, l’étude propose d’aller vers la ville réelle d’aujourd’hui et de reconnaître en elle un projet potentiel qui n’attend que des écrivains, des cinéastes, des penseurs pour avoir des assises imaginaires solides. Abolissant le périphérique, liant le centre historique aux banlieues, ce projet vise à donner naissance à cette grande métropole multiculturelle de 10 millions d’habitants qui porte déjà un nom, celui de « Grand Paris ».
Vivre et écrire Hochelaga
Authors: Cambron Micheline
Published: April 2015

Le roman montréalais actuel configure souvent un espace géographique beaucoup plus vaste que la ville elle-même, celle-ci se situant au croisement de trajectoires qui étendent ses frontières imaginaires aux dimensions du monde. Pensons à  Nikolski   de Nicolas Dickner, par exemple, ou au dernier roman de Monique LaRue,  L’Œil de Marquise. Mais, tout aussi bien, certains écrivains choisissent, dans un mouvement inverse, de condenser l’espace urbain, saisissant Montréal à travers l’un de ses quartiers. Je me pencherai sur deux oeuvres fort différentes, le roman  20h17 rue Darling  de Bernard Émond, et le recueil de poèmes  L’Œil au calendrier  de Gabriel Landry, afin de comprendre comment l’urbanité montréalaise s’y vit dans les limites d’un quartier, Hochelaga, qui devient ainsi l’incarnation intime de la ville. Je m’intéresserai à la forme qui se trouve donnée au temps, dans cet espace métonymique, et à la manière dont le temps et l’espace se trouvent croisés au fil des déambulations des sujets narrateurs qui font d’Hochelaga le lieu improbable du vivre-ensemble montréalais le plus contemporain.
Sur la banquette arrière d’un taxi montréalais : à propos de Cosmos (1996)
Authors: Harel Simon
Published: April 2015

Faisant appel au film culte Cosmos (1996), Simon Harel étudie les figures montréalaises de la mobilité géographique et culturelle. À ce sujet, le taxi représente, dans Cosmos, un espace identitaire, capteur de mobilité, traceur de parcours autant réels qu’imaginaires et figure emblématique de la ville. Cette analyse permet une réflexion sur les récits de soi et d’espace du sujet en mouvement. Aux yeux de Simon Harel, le chauffeur de taxi est un véritable « homme-récit » (pour reprendre l’expression de Tzvetan Todorov) ayant une fonction d’interprète de la parole des autres, de l’actualité de la vie urbaine et de la tradition orale.
Martine Sonnet et le Montparnasse monde : « un petit écosystème dans la symbiose générale »
Authors: Brière Émilie
Published: April 2015

La gare Montparnasse est emblématique d’une certaine conception de l’urbanisme parisien et de l’évolution de ses principes depuis les années 1960 : brouillage des frontières entre centre et périphérie ; nouveaux modes de transit et démocratisation du tourisme ; gestion ergonomique des espaces en trajets standardisés, dont le fléchage guide des foules aveugles d’individus indifférents et indifférenciés. Pendant quelques années, Martine Sonnet « lit » la gare, lui cherche des significations et interroge la possibilité d’« habiter » ce non-lieu. En résulte un projet multimédia : sur son blogue, elle collecte images et courts vidéos de la vie quotidienne dans l’univers ferroviaire. Dans son récit, paru en 2011, elle rassemble ses observations et ses souvenirs. Le style télégraphique de sa prose entérine la disparition du sujet au profit d’un usager anonyme et désincarné. Pour autant, sa description du « Montparnasse monde » laisse progressivement place à des îlots de narration de plus en plus nombreux, et donne à voir des aventures, accidents et accrocs de vie réelle que la normalisation voulue par les principes d’urbanisation moderne n’est pas parvenue à éradiquer tout à fait. Ce qui se donne au premier abord comme un univers déshumanisé, en camaïeux de gris et entrecroisements d’escaliers mécaniques, apparaît progressivement comme un écosystème que le vécu personnel, la mémoire familiale et l’histoire sociale ne cessent de colorer. La chose n’est pas banale pour qui fréquente régulièrement la gare Montparnasse : par la description très personnelle qu’elle en fait, Martine Sonnet parvient à élaborer une image de la gare qui traduit sa profonde « empathie pour le Montparnasse monde », et par-delà, pour le Paris du début du XXIe siècle.
En terrains connus ou « choses vues » dans Paris : Night and Day (2008) de Hong Sang-soo
Authors: Habib André
Published: April 2015

Paris est, avec peut-être New York comme seul rival, un des « personnages » les plus illustres de l’histoire du cinéma. Des « vues Lumière » jusqu’aux pérégrinations des héros de la Nouvelle Vague, de la psychogéographie de Debord aux cartographies affectives de Rohmer, en passant par les Paris vu par (1965, 1985) et autres Paris je t’aime (2006), peu de villes ont été autant filmées, et peu de villes ont eu autant d’influence sur l’imaginaire cinématographique. Il est notamment fascinant de constater la migration de cet imaginaire au sein des cinématographies asiatiques contemporaines. Cet article se penche sur le film Night and Day (2008) de Hong Sang-soo, tourné principalement dans le XIVe arrondissement à Paris, seul film de ce cinéaste sud-coréen à avoir été réalisé à l’extérieur de son pays. Le cinéma de Hong Sang-soo tourne autour d’un périmètre très limité et obsessif de lieux (cafés, bars, appartements), de quartiers et de situations (beuveries, triangles amoureux, vacances). Night and Day, avec le XIVe arrondissement comme toile de fond, en offre une énième variation, délocalisée, certes, mais totalement marquée par la présence du familier. Plutôt que d’être une expérience de la ville fondée sur le choc des cultures ou la rencontre avec l’autre,  Night and Day  propose un regard tout à fait décomplexé sur Paris, attentif aux « choses vues » les plus triviales, et marqué par un attachement aux lieux ordinaires, au commun, au quotidien, aux parcours du héros (qui n’y rencontre, à peu de choses près, que des Coréens). Par ailleurs, comme pour Tsai Ming-liang (Et là-bas, quelle heure est-il ? [2001],  Visage [2009]) ou Hou Hsiao-hsien (Le Voyage du ballon rouge, 2007), l’appropriation de Paris est indissociable d’une culture cinéphilique (en l’occurrence, dans le cas de Hong Sang-soo, du cinéma de Rohmer). Il s’agira donc d’essayer de décrire les modes d’appropriation de l’espace de la ville dans ce film, et l’imaginaire culturel par lequel ils transitent.
Les mots et les maux de Marseille : La Ville sans nom de Frédéric Valabrègue
Authors: Dorais Amélie , Popovic Pierre
Published: April 2015

Campé du côté de la Calanque de Maldormé, un SDF nommé Faria harangue et interpelle ceux qu’il appelle les « Innommables », c’est-à-dire les Marseillais (la ville fut privée de son nom durant quelques mois en 1794 par la Convention). Le choix décentré du lieu, la faconde et le caractère du personnage, le jeu sur l’intertexte (Le Comte de Monte-Cristo de Dumas et son abbé Faria), l’hétérogénéité générique (roman, monologue, résidus épiques) sont autant de moyens mis au service d’une critique des repères culturels, des schémas discursifs, du légendaire et des stéréotypes marseillais. C’est ainsi toute la rumeur sociale d’une ville qui est prise en écharpe, innervée par un orateur des quais qui, tour à tour, se révèle rhapsode, prédicateur ou prophète.
Analyse critique du concept de sacré chez Kenneth I. Pargament dans la définition de la spiritualité en contexte médical
Authors: Pujol Nicolas
Published: April 2015

L’auteur montre, à partir d’une analyse critique de la catégorie de « sacré », que le modèle d’intégration de la spiritualité à l’hôpital proposé par Kenneth I. Pargament véhicule des normativités qui peuvent générer des tensions éthiques sur le plan de la clinique. Cet article rappelle qu’une catégorie comme celle de « spiritualité » doit demeurer un outil opérationnel qui participe à la connaissance du monde, et que, pour cela, elle doit sans cesse faire l’objet de questions et d’évaluation de la part de ceux et celles qui l’utilisent.
Aristote, Leo Strauss et le droit naturel
Authors: Mansuy Daniel
Published: April 2015

L’article que nous présentons est une analyse de la lecture que fait Leo Strauss du passage où Aristote distingue entre la justice naturelle et la justice positive. Tout en voulant s’écarter des interprétations thomiste et marsilienne, Strauss suggère une position paradoxale qui, tout en admettant qu’il y a un droit naturel, rejette l’existence des principes de justice immuables. Notre thèse est que l’interprétation de Strauss n’est pas complètement fidèle au texte d’Aristote, et présente en fait sa propre position comme étant aristotélicienne.
Ultrahigh‐Gain Single SnO2 Microrod Photoconductor on Flexible Substrate with Fast Recovery Speed
Authors: Liu Kewei , Sakurai Makoto , Aono Masakazu , Shen Dezhen
Published: April 2015

Owing to the special properties and wide applications, UV photodetectors based on wide‐band‐gap semiconductors have drawn an increasing interest during the last two decades. However, practical UV photodetectors are required two contradictory performances: high internal gain and fast recovery speed, because high internal gain is achieved by long life time of photoexcited carriers and fast recovery needs their fast decay. Their slow decay in wide‐band‐gap semiconductors has been known as a persistent photoconductivity (PPC) problem and hinders applications. In this paper, a good solution to the above contradictory problem is demonstrated on a single SnO2 microrod photoconductor, which shows both high photoconductive gain (≈1.5 × 109) and quick recovery speed (<1 s). Notably, the quick recovery speed is associated with the removal of the persistent photoconductivity effect (>1 d), which is induced by a novel “reset” process: bending and straightening the microrod and subsequently applying a voltage pulse. This result suggests that SnO2 microrods have potential applications in high‐performance UV photodetecting devices.
Natural and Synthetic Materials for Self‐Renewal, Long‐Term Maintenance, and Differentiation of Induced Pluripotent Stem Cells
Authors: Dzhoyashvili Nina A. , Shen Sanbing , Rochev Yury A.
Published: April 2015

Induced pluripotent stem cells (iPSCs) have attracted considerable attention from the public, clinicians, and scientists since their discovery in 2006, and raised huge expectations for regenerative medicine. One of the distinctive features of iPSCs is their propensity to differentiate into the cells of three germ lines in vitro and in vivo. The human iPSCs can be used to study the mechanisms underlying a disease and to monitor the disease progression, for testing drugs in vitro, and for cell therapy, avoiding many ethical and immunologic concerns. This technology offers the potential to take an individual approach to each patient and allows a more accurate diagnosis and specific treatment. However, there are several obstacles that impede the use of iPSCs. The derivation of fully reprogrammed iPSCs is expensive, time‐consuming, and demands meticulous attention to many details. The use of biomaterials could increase the efficacy and safety while decreasing the cost of tissue engineering. The choice of a substrate utilized for iPSC culture is also important because cell‐substrate contacts influence cellular behavior such as self‐renewal, expansion, and differentiation. This Progress Report aims to summarize the advantages and drawbacks of natural and synthetic biomaterials, and to evaluate their role for maintenance and differentiation of iPSCs.
Paper‐Based Inkjet‐Printed Microfluidic Analytical Devices
Authors: Yamada Kentaro , Henares Terence G. , Suzuki Koji , Citterio Daniel
Published: April 2015

Rapid, precise, and reproducible deposition of a broad variety of functional materials, including analytical assay reagents and biomolecules, has made inkjet printing an effective tool for the fabrication of microanalytical devices. A ubiquitous office device as simple as a standard desktop printer with its multiple ink cartridges can be used for this purpose. This Review discusses the combination of inkjet printing technology with paper as a printing substrate for the fabrication of microfluidic paper‐based analytical devices (μPADs), which have developed into a fast‐growing new field in analytical chemistry. After introducing the fundamentals of μPADs and inkjet printing, it touches on topics such as the microfluidic patterning of paper, tailored arrangement of materials, and functionalities achievable exclusively by the inkjet deposition of analytical assay components, before concluding with an outlook on future perspectives.
Dynamic metabolic engineering: New strategies for developing responsive cell factories
Authors: Brockman Irene M. , Prather Kristala L. J.
Published: April 2015

Metabolic engineering strategies have enabled improvements in yield and titer for a variety of valuable small molecules produced naturally in microorganisms, as well as those produced via heterologous pathways. Typically, the approaches have been focused on up‐ and downregulation of genes to redistribute steady‐state pathway fluxes, but more recently a number of groups have developed strategies for dynamic regulation, which allows rebalancing of fluxes according to changing conditions in the cell or the fermentation medium. This review highlights some of the recently published work related to dynamic metabolic engineering strategies and explores how advances in high‐throughput screening and synthetic biology can support development of new dynamic systems. Dynamic gene expression profiles allow trade‐offs between growth and production to be better managed and can help avoid build‐up of undesired intermediates. The implementation is more complex relative to static control, but advances in screening techniques and DNA synthesis will continue to drive innovation in this field.
MED12 exon 2 mutations in phyllodes tumors of the breast
Authors: Nagasawa Satoi , Maeda Ichiro , Fukuda Takayo , Wu Wenwen , Hayami Ryosuke , Kojima Yasuyuki , Tsugawa Ko‐ichiro , Ohta Tomohiko
Published: April 2015

Exon 2 of MED12, a subunit of the transcriptional mediator complex, has been frequently mutated in uterine leiomyomas and breast fibroadenomas; however, it has been rarely mutated in other tumors. Although the mutations were also found in uterine leiomyosarcomas, the frequency was significantly lower than in uterine leiomyomas. Here, we examined the MED12 mutation in phyllodes tumors, another biphasic tumor with epithelial and stromal components related to breast fibroadenomas. Mutations in MED12 exon 2 were analyzed in nine fibroadenomas and eleven phyllodes tumors via Sanger sequencing. A panel of cancer‐ and sarcoma‐related genes was also analyzed using Ion Torrent next‐generation sequencing. Six mutations in fibroadenomas, including those previously reported (6/9, 67%), and five mutations in phyllodes tumors (5/11, 45%) were observed. Three mutations in the phyllodes tumors were missense mutations at Gly44, which is common in uterine leiomyomas and breast fibroadenomas. In addition, two deletion mutations (in‐frame c.133_144del12 and loss of splice acceptor c.100‐68_137del106) were observed in the phyllodes tumors. No other recurrent mutation was observed with next‐generation sequencing. Frequent mutations in MED12 exon 2 in the phyllodes tumors suggest that it may share genetic etiology with uterine leiomyoma, a subgroup of uterine leiomyosarcomas and breast fibroadenoma.
One‐Pot Synthesis of N‐Substituted β‐Amino Alcohols from Aldehydes and Isocyanides
Authors: Cioc Răzvan C. , van der Niet Daan J. H. , Janssen Elwin , Ruijter Eelco , Orru Romano V. A.
Published: April 2015

A practical two‐stage one‐pot synthesis of N‐substituted β‐amino alcohols using aldehydes and isocyanides as starting materials has been developed. This method features mild reaction conditions, broad scope, and general tolerance of functional groups. Based on a less common central carbon–carbon bond disconnection, this protocol complements traditional approaches that involve amines and various carbon electrophiles (epoxides, α‐halo ketones, β‐halohydrins). Medicinally relevant products can be prepared in a concise and efficient way from simple building blocks, as demonstrated in the synthesis of the antiasthma drug salbutamol. Upgrading the synthesis to an enantioselective variant is also feasible.
ChemInform Abstract: Crystal Structure of the Ternary Silicide Gd2Re3Si5.
Authors: Fedyna Vitaliia , Kozak Roksolana , Gladyshevskii Roman
Published: April 2015

Single crystals of Gd2Re3Si5 are isolated from an alloy of the nominal composition Gd20Re30Si50 synthesized by arc melting under Ar (Al2O3 crucible in Ta container, 1623 K, 5 h).
ChemInform Abstract: [M4Sn4Se17]10‐ Cluster Anions (M: Mn, Zn, Cd) in a Cs+ Environment and as Ternary Precursors for Ionothermal Treatment.
Authors: Santner Silke , Dehnen Stefanie
Published: April 2015

Compounds (III) and (IV) are characterized by single crystal XRD and UV/VIS spectroscopy.
ChemInform Abstract: Gold—Gold Bonding: The Key to Stabilizing the 19‐Electron Ternary Phases LnAuSb (Ln: La—Nd and Sm).
Authors: Seibel Elizabeth M. , Schoop Leslie M. , Xie Weiwei , Gibson Quinn D. , Webb James B. , Fuccillo Michael K. , Krizan Jason W. , Cava Robert J.
Published: April 2015

The title compounds are prepared from mixtures of the corresponding rare earth metal, AuSb2, and Au by arc‐melting in argon followed by annealing at 850 °C for 48 h.
ChemInform Abstract: Ligand Free Copper‐Catalyzed N‐Arylation of Heteroarylamines.
Authors: Wang Deping , Kuang Daizhi , Zhang Fuxing , Liu Yang , Ning Shunhua
Published: April 2015

The novel protocol allows the coupling of a wide range of aryl iodides and bromides with hetarylamines.
ChemInform Abstract: Direct Reductive Amination of 5‐Hydroxymethylfurfural with Primary/Secondary Amines via Ru‐Complex Catalyzed Hydrogenation.
Authors: Xu Zhanwei , Yan Peifang , Xu Wenjuan , Jia Songyan , Xia Zhi , Chung Benjamin , Zhang Z. Conrad
Published: April 2015

A wide range of primary and secondary amines are used for the direct reductive amination of bio‐based 5‐hydroxymethylfurfural (I) using the complex dichlorobis(2,9‐dimethyl‐1,10‐phenanthroline)ruthenium(II) as efficient catalyst and H2 as reductant.
ChemInform Abstract: Microwave‐Assisted Tandem Organocatalytic Peptide‐Coupling Intramolecular aza‐Michael Reaction: α,β‐Unsaturated N‐Acyl Pyrazoles as Michael Acceptors.
Authors: Sanchez‐Rosello Maria , Mulet Cristina , Guerola Marta , del Pozo Carlos , Fustero Santos
Published: April 2015

Conjugated N‐acyl pyrazoles are successfully employed in the organocatalytic enantioselective intramolecular aza‐Michael reaction as ester surrogates.
ChemInform Abstract: Intramolecular Anion Effect in Polyoxometalate‐Based Organocatalysts: Reactivity Enhancement and Chirality Transfer by a Metal Oxide‐Organic Cation Interaction.
Authors: Brazel Christian , Dupre Nathalie , Malacria Max , Hasenknopf Bernold , Lacote Emmanuel , Thorimbert Serge
Published: April 2015

An α1‐Dawson polyanion bearing a lateral side chain with a 4‐aminopyridine end group is synthesized.
ChemInform Abstract: Amide Groups Switch Selectivity: C—H Trifluoromethylation of α,β‐Unsaturated Amides and Subsequent Asymmetric Transformation.
Authors: Li Lei , Guo Jing‐Yao , Liu Xing‐Guo , Chen Su , Wang Yong , Tan Bin , Liu Xin‐Yuan
Published: April 2015

The first direct C—H β‐trifluoromethylation of unsubstituted or α‐alkyl‐substituted α,β‐unsaturated carbonyl compounds under metal‐free conditions is presented.
ChemInform Abstract: Diversity‐Oriented Approach to CF3CHF‐, CF3CFBr‐, CF3CF2‐, (CF3)2CH‐, and CF3(SCF3)CH‐Substituted Arenes from 1‐(Diazo‐2,2,2‐trifluoroethyl)arenes.
Authors: Emer Enrico , Twilton Jack , Tredwell Matthew , Calderwood Samuel , Collier Thomas Lee , Liegault Benoit , Taillefer Marc , Gouverneur Veronique
Published: April 2015

The reaction of various (diazotrifluoroethyl)arenes with HF, F/Br, F2, CF3H, and CF3SH sources give direct access to a variety of perfluoroalkyl‐substituted arenes presenting with incremental fluorine content.
ChemInform Abstract: Tungsten‐Catalyzed Regio‐ and Enantioselective Aminolysis of trans‐2,3‐Epoxy Alcohols: An Entry to Virtually Enantiopure Amino Alcohols.
Authors: Wang Chuan , Yamamoto Hisashi
Published: April 2015

The first catalytic enantioselective aminolysis of trans‐2,3‐epoxy alcohols is accomplished in the presence of a tungsten/bis(hydroxamic acid) catalytic system.
ChemInform Abstract: CAN‐Catalyzed Rapid C—O Bond Formation Towards α‐Aminoxylation of Ketones.
Authors: Feng Peng , Song Song , Zhang Li‐He , Jiao Ning
Published: April 2015

The simple and rapid aminoxylation of 1,3‐diones with TEMPO in presence of ceric ammonium nitrate catalyst but without strong bases furnishes the α‐substituted products in good yields.
ChemInform Abstract: Dual Role of Alkynyl Bromides in One‐Step Synthesis of Bromo‐Substituted Alkynyl Sulfides.
Authors: Yang Yuan , Huang Hui , Liu Wei , Liang Yun
Published: April 2015

The first additive‐free method for the formation of bromo‐substituted alkynyl sulfides (III) is reported.
ChemInform Abstract: Iron‐Catalyzed Thioesterification of Methylarenes with Thiols in Water.
Authors: Wang Liang , Cao Jing , Chen Qun , He Ming‐yang
Published: April 2015

The oxidative coupling of methylarenes with thiols tolerates various functional groups in both partners and gives thioesters in moderate to good yields.
ChemInform Abstract: Gold‐Catalyzed Dearomative Spirocyclization of Aryl Alkynoate Esters.
Authors: Aparece Mark D. , Vadola Paul A.
Published: April 2015

The dearomative spirocyclization of aryl alkynoate esters can be achieved by gold catalysis to afford a broad scope of spirocyclic lactones in good to excellent yields in short reaction times under mild conditions.
ChemInform Abstract: Enantioselective Intramolecular C—H Insertion Reactions of Donor—Donor Metal Carbenoids.
Authors: Soldi Cristian , Lamb Kellan N. , Squitieri Richard A. , Gonzalez‐Lopez Marcos , Di Maso Michael J. , Shaw Jared T.
Published: April 2015

The first asymmetric insertion reactions of donor‐donor carbenoids, which have no pendant electron‐withdrawing groups, are reported.
ChemInform Abstract: Synthesis of N‐Alkyl Pyrroles via Decarboxylation/Dehydration in Neutral Ionic Liquid under Catalyst‐Free Conditions.
Authors: Yadav Veena D. , Dighe Shashikant U. , Batra Sanjay
Published: April 2015

A general route to N‐alkyl pyrroles by reacting aromatic, heteroaromatic or aliphatic aldehydes with 4‐hydroxyproline in ionic liquid under neutral conditions is developed.
ChemInform Abstract: Auto‐Oxidative Coupling of Glycine Derivatives.
Authors: Huo Congde , Yuan Yong , Wu Mingxia , Jia Xiaodong , Wang Xicun , Chen Fengjuan , Tang Jing
Published: April 2015

The reaction of glycine derivatives with indoles under O2 atmosphere gives C‐arylated indol‐3‐yl derivatives regioselectively.
ChemInform Abstract: Palladium‐Catalyzed Synthesis of 2‐Allylindole and 2‐Allylbenzofuran Derivatives from 2‐((Trimethylsilyl)ethynyl)arenes.
Authors: Chakraborty Amrita , Jyothi Konanki , Sinha Surajit
Published: April 2015

The stereoselectivity of the prepared indole derivatives is controlled by the N‐protecting group of the 2‐((trimethylsilyl)ethynyl)aniline substrates.
ChemInform Abstract: Reductive Coupling of Isatins with Ketones and Aldehydes by Low‐Valent Titanium.
Authors: Kise Naoki , Sasaki Kouta , Sakurai Toshihiko
Published: April 2015

The reductive coupling of isatin and N‐methylisatin with aldehydes or ketones in presence of Zn/TiCl4 is selectively controlled by the reaction conditions.
ChemInform Abstract: “Quick and Click” Assembly of Functionalised Indole Rings via Metal‐Promoted Cyclative Tandem Reactions.
Authors: Capitta Francesca , De Luca Lidia , Porcheddu Andrea
Published: April 2015

N‐Protected 2‐iodoanilines are smoothly transformed into indoles by a sequential Castro reaction using aldehydes instead of the commonly utilized alkynes.
ChemInform Abstract: Efficient Synthesis of 2‐Aryl‐1‐arylmethyl‐1H‐benzimidazoles in Ball Mill Without Solvent.
Authors: Jin Meihong , Song Guowei , Li Zhenjiang , Zhou Feng , Fan Bo , Ouyang Pingkai
Published: April 2015

13 Title compounds of type (III) are prepared in a ball mill using FeCl3·6H2O as a catalyst.
ChemInform Abstract: Stereoselective Synthesis of cis‐and trans‐3,4,5‐Trisubstituted‐1,3‐oxazolidin‐2‐one Derivatives from 1,2‐Amino Alcohol Monoesters and Aziridine‐2‐carboxylates.
Authors: Kaabi Amani , Besbes Rafaa
Published: April 2015

New cis N‐alkyl‐1,3‐oxazolidin‐2‐ones (III) are formed in good yields via phosgenation of erythro‐1,2‐aminoalcohol monoesters, accompanied by the formation of aziridine by‐products.
ChemInform Abstract: General and Efficient Synthesis of Benzoxazol‐2(3H)‐ones: Evolution of Their Anticancer and Antimycobacterial Activities.
Authors: Indrasena Reddy K. , Aruna C. , Sudhakar Babu K. , Vijayakumar V. , Manisha M. , Padma Sridevi J. , Yogeeswari P. , Sriram D.
Published: April 2015

A variety of novel benzo[d]oxazol‐2(3H)‐one derivatives are synthesized and screened for their in vitro cytotoxicity against human pancreatic adenocarcinoma and human non‐small cell lung carcinoma cell lines.
ChemInform Abstract: Hydrosilane‐Promoted Cyclization of 2‐Aminothiophenols by CO2 to Benzothiazoles.
Authors: Gao Xiang , Yu Bo , Zhao Yanfei , Hao Leiduan , Liu Zhimin
Published: April 2015

The method is an environmentally benign approach for the synthesis of benzothiazoles and achieves the C‐S chemical bond construction using CO2 as C‐1 building block.
ChemInform Abstract: Domino Bicyclization of 2,2‐Dihydroxyindene‐1,3‐dione with Cyclic Enaminones Leading to Isochromeno[4,3‐b]indoles.
Authors: Zhao Fu‐Jie , Sun Mu‐Yan , Dang Yi‐Jing , Meng Xiao‐Yan , Jiang Bo , Hao Wen‐Juan , Tu Shu‐Jiang
Published: April 2015

The new and operationally simple acid‐promoted domino reaction allows the direct assemble of functionalized, tetracyclic isocoumarin scaffolds.
ChemInform Abstract: Catalyst‐Free Synthesis of (E)‐2‐Alkenylquinoline Derivatives via C(sp3)‐H Functionalization of 2‐Methylquinolines.
Authors: Xu Lubin , Shao Zhuzhou , Wang Liang , Zhao Huaili , Xiao Jian
Published: April 2015

The electronic properties of the aromatic aldehydes do not only influence the reaction yields, but also whether E‐alkenylquinoline derivatives are obtained exclusively or together with hydrated or dimerized products.
ChemInform Abstract: Rhodium‐Catalyzed Direct Oxidative C—H Acylation of 2‐Arylpyridines with Terminal Alkynes: A Synthesis of Pyrido[2,1‐a]isoindoles.
Authors: Zhao Binlin , Yu Mengxuan , Liu Hui , Chen Yu , Yuan Yu , Xie Xuejian
Published: April 2015

The title reaction offers an efficient and clean method to synthesize pyridoisoindoles in moderate to excellent yields in the presence of Cu salts.
ChemInform Abstract: Heterocycle‐to‐Heterocycle Route to Quinoline‐4‐amines: Reductive Heterocyclization of 3‐(2‐Nitrophenyl)isoxazoles.
Authors: Coffman Keith C. , Duong Vy , Bagdasarian Alex L. , Fettinger James C. , Haddadin Makhluf J. , Kurth Mark J.
Published: April 2015

A variety of quinoline‐4‐amines are synthesized from substituted 3‐(2‐nitrophenyl)isoxazoles utilizing Zn or Fe dust and HOAc using a reductive heterocyclization process.
ChemInform Abstract: Sulfur Incorporation: Copper‐Catalyzed Cascade Cyclization of 1,7‐Enynes with Metal Sulfides Toward Thieno[3,4‐c]quinolin‐4(5H)‐ones.
Authors: Liu Yu , Zhang Jia‐Ling , Song Ren‐Jie , Li Jin‐Heng
Published: April 2015

This novel methodology succeeds for substrates equipped with aryl substituents on the alkyne moiety, but fails for correspondingly substituted alkyl derivatives.
ChemInform Abstract: Construction of Indoloquinolinones via Pd(II)‐Catalyzed Tandem C—C/C—N Bond Formation: Application to the Total Synthesis of Isocryptolepine.
Authors: Chen Xuebing , Sun Peng , Xu Jinyi , Wu Xiaoming , Kong Lingyi , Yao Hequan , Lin Aijun
Published: April 2015

The Pd‐catalyzed reaction of indole‐3‐carboxamides with aryl iodides affords indoloquinolinones in moderate yields.
ChemInform Abstract: Spiro‐β‐Lactams Synthesized from Imines Derived from 8‐Azabicyclo[3.2.1]octan‐3ones.
Authors: Song Ju‐Hyun , Kwon Yeon‐Geun , Lee Hyun‐Ok , Jung Dai‐Il , Hahn Jung‐Tai
Published: April 2015

The synthesis of a new class of spiro‐β‐lactams (VIII) having an 8‐azabicyclo[3.2.1]octan‐3‐one ring is described using the Staudinger reaction as key step.
ChemInform Abstract: Acceptorless Dehydrogenative Synthesis of 2‐Substituted Quinazolines from 2‐Aminobenzylamine with Primary Alcohols or Aldehydes by Heterogeneous Pt Catalysts.
Authors: Chaudhari Chandan , Hakim Siddiki S. M. A. , Tamura Masazumi , Shimizu Ken‐ichi
Published: April 2015

The ceria‐supported catalyst is recyclable and reusable at least 2 times.
ChemInform Abstract: Serendipitous Discovery of 2‐((Phenylsulfonyl)methyl)‐thieno[3,2‐d]pyrimidine Derivatives as Novel HIV‐1 Replication Inhibitors.
Authors: Lee Jinhwa
Published: April 2015

New thienopyrimidine derivatives (IIa) and (IIb) exhibit significant inhibitory activities against HIV‐1 replication.
ChemInform Abstract: Mannich Reaction as a New Route for the Synthesis of Tetrahydro Pyrimido Benzimidazolyl Coumarins.
Authors: Madhura V. , Kulkarni Manohar V. , Shah Amol , Alagawadi Kallanagouda R.
Published: April 2015

15 Title compounds of type (IV) are prepared and tested for their anti‐inflammatory activities.
ChemInform Abstract: Phenazines and Their N‐Oxides as Products of Cyclization of N‐Aryl‐2‐nitrosoanilines — Disproof of the Reported Homolytic Cross‐Coupling Process Leading to Benzo[c]cinnoline Oxides.
Authors: Wrobel Zbigniew , Stachowska Karolina , Kwast Andrzej
Published: April 2015

No evidence is found for the reported formation of benzo[c]cinnoline oxides in the KOtBu‐mediated homolytic cross‐coupling reaction of anilines with nitroarenes.
ChemInform Abstract: Inducamides A—C, Chlorinated Alkaloids from an RNA Polymerase Mutant Strain of Streptomyces sp.
Authors: Fu Peng , Jamison Matthew , La Scott , MacMillan John B.
Published: April 2015

Inducamide A (Ia), B (Ib) and C (II) are shown to not exhibit significant antibacterial activity, but (II) reveals modest cytotoxicity.
ChemInform Abstract: Stereoselective Total Synthesis of epi‐Phomopsolide B.
Authors: Emmadi Narender Reddy , Bingi Chiranjeevi , Ganesh Kumar Chityal , Yedla Poornachandra , Atmakur Krishnaiah
Published: April 2015

The title compound (I) shows cytotoxic activity against HeLa, A549, DU145 and HepG2 cell lines and antimicrobial activity against Staphylococcus aureus MLS‐16 MTCC 2940 and Bacillus subtilis MTCC 121.
ChemInform Abstract: New Cytotoxic Naphthohydroquinone Dimers from Rubia alata.
Authors: Zhao Si‐Meng , Wang Zhe , Zeng Guang‐Zhi , Song Wei‐Wu , Chen Xiao‐Qiang , Li Xiao‐Nian , Tan Ning‐Hua
Published: April 2015

The cytotoxicity of (I) and its enantiomer, rubialatin B (II) and their biosynthetic precursor mollugin (III) is investigated.
ChemInform Abstract: New Flavonol Methyl Ether from the Leaves of Vitex peduncularis Exhibits Potential Inhibitory Activity Against Leishmania donovani Through Activation of iNOS Expression.
Authors: Rudrapaul Prasenjit , Sarma Indrajit Sil , Das Niranjan , De Utpal Chandra , Bhattacharjee Surajit , Dinda Biswanath
Published: April 2015

New flavonol methyl ether, vitecetin (I), is isolated together with four known compounds from the leaves of Vitex peduncularis.
ChemInform Abstract: Recent Developments in the Chemistry of Heteroaromatic N‐Oxides
Authors: Wang Youliang , Zhang Liming
Published: April 2015

Review: [72 refs.
ChemInform Abstract: 6,6‐Dicyanopentafulvenes: Teaching an Old Dog New Tricks
Authors: Finke Aaron D. , Diederich Francois
Published: April 2015

Review: [a brief history of the chemistry of DCFs followed by a summary of the authors work; 28 refs.
ChemInform Abstract: Towards meso‐meso‐Linked Porphyrin Arrays and meso‐Aryl Expanded Porphyrins
Authors: Osuka Atsuhiro
Published: April 2015

Review: 117 refs.
ChemInform Abstract: Detection of Nitroaromatic Explosives with Fluorescent Molecular Assemblies and π‐Gels
Authors: Kartha Kalathil K. , Sandeep Anjamkudy , Praveen Vakayil K. , Ajayaghosh Ayyappanpillai
Published: April 2015

Review: [47 refs.
ChemInform Abstract: Diels—Alder Reactions with the <C=P—Functionality of Anellated Azaphospholes
Authors: Bansal Raj K. , Gupta Raakhi , Kour Manjinder
Published: April 2015

Review: [36 refs.
ChemInform Abstract: Advances in Direct C—H Arylation of 5,5‐ 6,5‐ and 6,6‐Fused‐Heterocycles Containing Heteroatoms (N, O, S)
Authors: El Kazzouli Said , Koubachi Jamal , El Brahmi Nabil , Guillaumet Gerald
Published: April 2015

Review: 166 refs.
ChemInform Abstract: 1,5‐Benzodiazepine‐2,4‐diones: Synthesis, Reactivity, Physico‐Chemical and Biological Properties
Authors: Kandri Rodi Y. , Misbahi K. , Essassi E. M.
Published: April 2015

Review: 65 refs.
ChemInform Abstract: Greener Approaches to Cross‐Coupling
Authors: Shaughnessy Kevin H.
Published: April 2015

Review: 264 refs.