bluuebunny/crossref_metadata_2025 huggingface dataset:
FIGURE 1 from PARP Inhibitors Effectively Reduce MAPK Inhibitor Resistant Melanoma Cell Growth and Synergize with MAPK Inhibitors through a Synthetic Lethal Interaction In Vitro and In Vivo
Authors: Fröhlich Lisa Marie , Niessner Heike , Sauer Birgit , Kämereit Sofie , Chatziioannou Eftychia , Riel Simon , Sinnberg Tobias , Schittek Birgit
Published: September 2023

MAPKi resistant melanoma cells are highly susceptible to PARPi treatment. A, MUH cell viability assay of vemurafenib sensitive (S) and resistant (R) melanoma cell lines as well as PDX R cells treated with different concentrations of PARPi (olaparib and talazoparib) starting at 100 μmol/L for 72 hours. Comparison of fits of the nonlinear regression was performed to analyze statistical differences between S and R cells. IC50 levels are shown. B, NSG mice were treated with 2 mg/kg/day talazoparib (Tala.) or the same solvent without talazoparib (Ctr.). The xenograft tumor volume in percent compared with treatment start over time is shown. C, The final tumor volume of the individual mice is depicted. Multiple t test was used to compare the control (Ctr.) group to the talazoparib (Tala.) group. D, Representative pictures of the excised tumors are illustrated.
Supplementary Methods from Single-cell Profiling Uncovers a Muc4-Expressing Metaplastic Gastric Cell Type Sustained by Helicobacter pylori-driven Inflammation
Authors: O'Brien Valerie P. , Kang Yuqi , Shenoy Meera K. , Finak Greg , Young William C. , Dubrulle Julien , Koch Lisa , Rodriguez Martinez Armando E. , Williams Jeffery , Donato Elizabeth , Batra Surinder K. , Yeung Cecilia C.S. , Grady William M. , Koch Meghan A. , Gottardo Raphael , Salama Nina R.
Published: September 2023

Expanded Materials and Methods.
Figure S9 from Single-cell Profiling Uncovers a Muc4-Expressing Metaplastic Gastric Cell Type Sustained by Helicobacter pylori-driven Inflammation
Authors: O'Brien Valerie P. , Kang Yuqi , Shenoy Meera K. , Finak Greg , Young William C. , Dubrulle Julien , Koch Lisa , Rodriguez Martinez Armando E. , Williams Jeffery , Donato Elizabeth , Batra Surinder K. , Yeung Cecilia C.S. , Grady William M. , Koch Meghan A. , Gottardo Raphael , Salama Nina R.
Published: September 2023

Gating strategy for detection of myeloid cell populations by flow cytometry.
Figure S7 from Single-cell Profiling Uncovers a Muc4-Expressing Metaplastic Gastric Cell Type Sustained by Helicobacter pylori-driven Inflammation
Authors: O'Brien Valerie P. , Kang Yuqi , Shenoy Meera K. , Finak Greg , Young William C. , Dubrulle Julien , Koch Lisa , Rodriguez Martinez Armando E. , Williams Jeffery , Donato Elizabeth , Batra Surinder K. , Yeung Cecilia C.S. , Grady William M. , Koch Meghan A. , Gottardo Raphael , Salama Nina R.
Published: September 2023

Metaplastic pit cells expand within six weeks and are partially dependent on the Hp cag type IV secretion system.
Figure S12 from Single-cell Profiling Uncovers a Muc4-Expressing Metaplastic Gastric Cell Type Sustained by Helicobacter pylori-driven Inflammation
Authors: O'Brien Valerie P. , Kang Yuqi , Shenoy Meera K. , Finak Greg , Young William C. , Dubrulle Julien , Koch Lisa , Rodriguez Martinez Armando E. , Williams Jeffery , Donato Elizabeth , Batra Surinder K. , Yeung Cecilia C.S. , Grady William M. , Koch Meghan A. , Gottardo Raphael , Salama Nina R.
Published: September 2023

MUC4 and Ki-67 expression are significantly positively associated in samples from 47 subjects with gastric cancer.
Figure S1 from Single-cell Profiling Uncovers a Muc4-Expressing Metaplastic Gastric Cell Type Sustained by Helicobacter pylori-driven Inflammation
Authors: O'Brien Valerie P. , Kang Yuqi , Shenoy Meera K. , Finak Greg , Young William C. , Dubrulle Julien , Koch Lisa , Rodriguez Martinez Armando E. , Williams Jeffery , Donato Elizabeth , Batra Surinder K. , Yeung Cecilia C.S. , Grady William M. , Koch Meghan A. , Gottardo Raphael , Salama Nina R.
Published: September 2023

Summary of cell clusters detected in different mouse treatment groups at six and 12 weeks.
FIGURE 4 from Single-cell Profiling Uncovers a Muc4-Expressing Metaplastic Gastric Cell Type Sustained by Helicobacter pylori-driven Inflammation
Authors: O'Brien Valerie P. , Kang Yuqi , Shenoy Meera K. , Finak Greg , Young William C. , Dubrulle Julien , Koch Lisa , Rodriguez Martinez Armando E. , Williams Jeffery , Donato Elizabeth , Batra Surinder K. , Yeung Cecilia C.S. , Grady William M. , Koch Meghan A. , Gottardo Raphael , Salama Nina R.
Published: September 2023

Antibiotic eradication of Hp reverses metaplastic pit cell expansion. Muc4 and gastric inflammation were assessed 12 weeks after KRAS induction in the following groups: Hp−KRAS+ mice; Hp+KRAS+ mice; and Hp+KRAS+ mice treated with antibiotics (“abx”) from weeks 6 to 8. A, ISH was used to detect Muc4 (brown) in the corpus at 12 weeks and representative images are shown. Scale bars, 100 μm. B–E, IHC was used to detect the indicated immune cell populations in gastric corpus tissue at 12 weeks. Data are from N = 2 independent experiments with n = 5–10 mice per group. B, Representative images of the gastric corpus are shown. CD3 (yellow) indicates T cells, CD4 (red) indicates Th cells, CD8α (green) indicates cytotoxic T cells, F4/80 (gray) indicates macrophages and DAPI (blue) indicates nuclei. Higher magnification images of the boxed regions are shown in the second row. Scale bars, 100 μm. C–E, The indicated immune cell populations were detected by IHC and quantified in each mouse using HALO software in N = 2 experiments. Each datapoint is the average quantitation in two fields of view for an individual mouse and bars represent the medians. ***, P < 0.001; ****, P < 0.0001; Mann–Whitney U test; ns, not significant.
Table S5 from Clinical Benefit of Autologous Stem Cell Transplantation for Patients with Multiple Myeloma Achieving Undetectable Minimal Residual Disease after Induction Treatment
Authors: Liu Jiahui , Yan Wenqiang , Fan Huishou , Xu Jingyu , Li Lingna , Du Chenxing , Mao Xuehan , Yan Yuting , Xu Yan , Sui Weiwei , Deng Shuhui , Yi Shuhua , Anderson Kenneth C. , Qiu Lugui , Zou Dehui , An Gang
Published: September 2023

Patient and Treatment Characteristics in ASCT cohort: Sustained MRD-negative vs. Sustained MRD-positive
Table S2 from Clinical Benefit of Autologous Stem Cell Transplantation for Patients with Multiple Myeloma Achieving Undetectable Minimal Residual Disease after Induction Treatment
Authors: Liu Jiahui , Yan Wenqiang , Fan Huishou , Xu Jingyu , Li Lingna , Du Chenxing , Mao Xuehan , Yan Yuting , Xu Yan , Sui Weiwei , Deng Shuhui , Yi Shuhua , Anderson Kenneth C. , Qiu Lugui , Zou Dehui , An Gang
Published: September 2023

The impact of ASCT on PFS and OS among all patients
TABLE 1 from Clinical Benefit of Autologous Stem Cell Transplantation for Patients with Multiple Myeloma Achieving Undetectable Minimal Residual Disease after Induction Treatment
Authors: Liu Jiahui , Yan Wenqiang , Fan Huishou , Xu Jingyu , Li Lingna , Du Chenxing , Mao Xuehan , Yan Yuting , Xu Yan , Sui Weiwei , Deng Shuhui , Yi Shuhua , Anderson Kenneth C. , Qiu Lugui , Zou Dehui , An Gang
Published: September 2023

Patient and treatment characteristics by MRD status after induction treatment
Figure S2 from Clinical Benefit of Autologous Stem Cell Transplantation for Patients with Multiple Myeloma Achieving Undetectable Minimal Residual Disease after Induction Treatment
Authors: Liu Jiahui , Yan Wenqiang , Fan Huishou , Xu Jingyu , Li Lingna , Du Chenxing , Mao Xuehan , Yan Yuting , Xu Yan , Sui Weiwei , Deng Shuhui , Yi Shuhua , Anderson Kenneth C. , Qiu Lugui , Zou Dehui , An Gang
Published: September 2023

The prognostic impact of ASCT among all patients
Data from Single-cell Profiling Uncovers a Muc4-Expressing Metaplastic Gastric Cell Type Sustained by Helicobacter pylori-driven Inflammation
Authors: O'Brien Valerie P. , Kang Yuqi , Shenoy Meera K. , Finak Greg , Young William C. , Dubrulle Julien , Koch Lisa , Rodriguez Martinez Armando E. , Williams Jeffery , Donato Elizabeth , Batra Surinder K. , Yeung Cecilia C.S. , Grady William M. , Koch Meghan A. , Gottardo Raphael , Salama Nina R.
Published: September 2023

Mechanisms for Helicobacter pylori (Hp)-driven stomach cancer are not fully understood. In a transgenic mouse model of gastric preneoplasia, concomitant Hp infection and induction of constitutively active KRAS (Hp+KRAS+) alters metaplasia phenotypes and elicits greater inflammation than either perturbation alone. Gastric single-cell RNA sequencing showed that Hp+KRAS+ mice had a large population of metaplastic pit cells that expressed the intestinal mucin Muc4 and the growth factor amphiregulin. Flow cytometry and IHC-based immune profiling revealed that metaplastic pit cells were associated with macrophage and T-cell inflammation. Accordingly, expansion of metaplastic pit cells was prevented by gastric immunosuppression and reversed by antibiotic eradication of Hp. Finally, MUC4 expression was significantly associated with proliferation in human gastric cancer samples. These studies identify an Hp-associated metaplastic pit cell lineage, also found in human gastric cancer tissues, whose expansion is driven by Hp-dependent inflammation.
Significance:
Using a mouse model, we have delineated metaplastic pit cells as a precancerous cell type whose expansion requires Hp-driven inflammation. In humans, metaplastic pit cells show enhanced proliferation as well as enrichment in precancer and early cancer tissues, highlighting an early step in the gastric metaplasia to cancer cascade.
Indigenous Knowledge on Pest Management in Rice Production in the Province of Masbate
Authors: Dollison Mohammad D. , Dollison Beverly B.
Published: September 2023

A total of 90 rice farmers who are used in adopting IK in rice pest management were considered using a convenient sampling method in selecting respondents. The data were subjected to descriptive statistics. The result showed that 40% of rice farmers are 51-60 years old, male (80%), married (95%), elementary graduate (44%), with a household size of 1 to 5 members (70%), and 37% were engaged in farming for 5 to 10 years. Furthermore, farmers are dominated by the land owner (57%), planted traditional or local varieties (61%), with farm size of less than 1 hectare (47%), and obtained an average yield of 50 caravans per hectare (35%). Rice farmers claimed that IK was handed down by their ancestors with less intervention from agricultural institutions, and rice farmers have practiced it for 20 to 30 years. Most (32%) farmers perceived they were more familiar with indigenous knowledge than new technology. The level of awareness of IK on pest management in rice production in the province of Masbate revealed that rice farmers were aware of the IK practices with a weighted mean of 2.87. Furthermore, data also revealed that the level of utilization of rice farmers who utilized IK on pest management in rice production is often with a general weighted mean of 2.85. Similarly, the result shows that the IK practices on pest management in rice production in the province of Masbate are cost-effective, with a general weighted mean of 2.85.
Challenges in Implementing the Merdeka Belajar Kampus Merdeka in High-er Education
Authors: Sihombing Humiras Betty Marlina , Panjaitan Jelita
Published: September 2023

Curriculum changes are a must. In fact, the very fast development of science and technology no longer supports the world of education to linger with the "comfort zone" of the applicable curriculum. Popularly known as the merdeka belajar kampus merdeka, this policy is to realize a flexible learning process, create innovative, non-restrictive learning, according to student needs, encourage students to master various sciences that are useful for entering the world, as well as provide opportunities for students to determine their subjects. the course he will take. The problems of implementing the independent learning curriculum are 1) Collaboration Mechanisms between Islamic Universities and Study Programs with External Parties, 2) Acceleration of State Universities (PTN) Go International with the policy of PTN Legal Entities (PTN-BH), 3) Internship Mechanisms Outside the Program Policy Studies internship for 3 semesters outside the study program and PT.
Analysis Pragmatical Policy of Leadership Style Dynamics
Authors: Jamaluddin Muhammad Iqbal , Herawan Endang , Rahyasih Yayah , Pribadi Luthfi Audia
Published: September 2023

Pragmatic policy is a type of policy that prioritizes practicality and usefulness. Decision-making from this pragmatic policy has an impact on overlapping policies so that a suitable leadership style is needed to anticipate these policies. The purpose of this research is to analyze the appropriate and proportionate way of leadership style to anticipate pragmatic policies. method used. This research is a qualitative method with a phenomenological approach. This research was conducted in the Men's Dormitory of Middle and High School Alexandria International Islamic School with a sample of 2 people. The instruments used are observation, interviews and documentation studies. The results showed that the situational leadership style and delegative democracy were the most proportional and suitable leadership styles in accommodating crucial, fast and pragmatic policies. This has an impact on the consideration of policy implementation that is right on target and applied properly so that each line of coordination can display the best contribution to policy.
Financial Distress Risk Levels of Listed Small and Medium Enterprises in the Philippines
Authors: Rago Gensbergh G. , Gabriel Sarah Fe Sharon L. , Abellar Jonas B.
Published: September 2023

Small and Medium Enterprises (SME) play a significant role in the Philippine economy in terms of promoting entrepreneurship and technological innovation, encouraging local development and alleviate poverty levels. However, SMEs are more susceptible to financial constraints and difficulties attributable to limited access to capital and weak financial management practices, among others, which lead to financial distress and insolvency in the long run. Anchored on the Early Bankruptcy Theory, a company’s financial distress can be at-tributed to its inability to meet its obligations which stem from poor management, low profitability, inadequate cash flow, or excessive leverage, among others. Hence, the Study aimed at describing and determining the financial dis-tress risk levels of sample SMEs in order to provide valuable insights into the financial health and stability of these companies. Specifically, the Study ascertained the nature, determinants and levels of financial distress risks using the Altman Z-Score Model (1968). Based on the result, sample companies at SAFE levels were deemed to have strong financial positions with good profitability, liquidity, leverage, and solvency while sample companies at DISTRESS levels could experience financial difficulties with lack of liquidity, declining revenues, and reliance on debt financing from third parties. Future research can (1) expand the determination of financial distress risk levels into non-listed SMEs and other listed companies from key sectors using a longer time frame to assess changes in the financial distress risk levels resulting from changes in economic conditions and (2) investigate the impact of financial ratios on financial distress risk while also considering corporate governance measures affecting it.
The Impact of Body Positivity in Fashion Advertising on Customer Perceptions and Purchase Intentions
Authors: Tsawaab Amallia Husnuts
Published: September 2023

The fashion business is regarded as one of the most important industries in the world and contributes significantly to the world economy’s benefits. In the era of technology, applying the right management techniques for advertising is very important to succeed among commercial competitors in competitive markets. Even though advertising has so many positive effects, it also has a negative side, such as it could create unrealistic beauty and body standards due to the marketers using attractive, slender, and tall models which promotes the ideal body image in culture. The purpose of this research is to determine how impactful body diversity in advertising affects consumers' attitude toward advertisements and their desire to buy clothes, to determine what kind of models to utilize in fashion goods commercials to strengthen consumer perceptions of advertisements and buy intent, and to explore the effects of size inclusivity as the moderating variable of diversity in advertising and attitude toward the advertisements. The methodologies used in this study were qualitative and quantitative. As a result, the purpose of this study is to determine whether or not advertising that promotes body positivity has an impact on how consumers feel about advertisements and their intentions to buy from fashion retailers, which type of model's body, a larger or slimmer one, has a greater effect on the consumer's perception of the advertising and their desire to purchase according to the customer's body type and sizes, and how size inclusivity becomes the moderating variable between advertisements and purchases.
Awareness of the Electronics Technology Students in Managing their E-waste: An Input for Developing an E-waste Management Policy
Authors: Goyal John Kenneth C.
Published: September 2023

This study seeks to gauge the degree of awareness of the VALPOLY Electronics Technology students on E-waste management. A total of 188 VALPOLY EST students enrolled in the academic year 2022-2023 were purposively selected to participate in the research. An adapted and modified survey questionnaire was used to assess VALPOLY EST students' level of awareness and the challenges they faced in managing their e-waste. Frequency counts, percentages, means, the Mann-Whitney U test, and the Kruskal Wallis test were used for statistical analysis and data handling. All questions were rated on a 4-point Likert scale with a 0.5 level of significance. Based on the findings, "Electronic Components" is the most common e-waste generated by the 188 VALPOLY EST students, while "CCTV", "Oven, Heaters, Cookware, Blender", "Washing Machines", and "Printers" are the least common e-waste generated during their technical training in their technical subjects. The majority of students also preferred "Resell to junkshops as scraps" as an e-waste disposal strategy, while "Take to the collection Centre" was the least preferred. The EST students' level of awareness in managing e-wastes was assessed with a grand mean of 2.62, showing that the VALPOLY EST students are "Aware" of managing their e-wastes. There is no significant difference in the degree of understanding of VALPOLY EST students on e-waste management based on age or gender, but there is a significant difference based on year level. The assessment of the VALPOLY EST students' concerns in managing their e-waste received a grand mean of 3.42, suggesting that the VALPOLY EST students "Strongly Agree" that there are challenges in managing their e-waste. Input through a set of recommendations was made to strengthen the institution's policy on controlling and treating waste and electronic waste.
Home-Based Enrichment Activities for Science 9 (Biology): Effects on Students’ Academic Performance and Science Engagement
Authors: Antipatia Jade Mark L.
Published: September 2023

This study aimed to develop Home-Based Enrichment Activities specifically designed for Science 9 and assess their impact on academic performance and engagement of Grade 9 students attending public high schools in the Philippines during the first quarter of the school year 2022-2023. This study employed both descriptive and quasi-experimental research methods. The instruments included the validated pre-test and post-test assessments, a survey questionnaire for teachers, and a survey sheet for students. The data was collected from (60) students, (15) high school teachers and (15) master teachers in science in public schools. The data gathered were statistically analyzed using weighted mean, percentage, independent-samples t-Test, paired t-Test, and z-Test. Results showed that the control group exhibited lower mean scores (4.33 and 29.33)  in the pretest and posttest compared to the experimental group (13.97 and 38.20), indicating a significant improvement in performance of the students, further affirming the positive impact of the developed Home-based enrichment activities on academic performance. The experimental group also expressed a high level of science learning engagement, demonstrating strong involvement, effort, and preparation in science lessons as manifested by the grand weighted mean of 3.88. Recommendations include incorporate home-based enrichment activities into blended learning modalities, particularly in modular distance learning to help students to learn the lesson and answer their modules on their own and increase students’ achievement in Science. Additionally, these supplementary activities can also provide valuable support to students who are at risk of failing a specific subject due to time constraints and challenging learning tasks within their modules.
Physical Activity Engagement Across Human Life Cycles: A Scoping Review
Authors: Castro Rafael Luis G. , Manalansan Lenard M. , Sibug Vanessa B.
Published: September 2023

Physical activities bring health benefits essential to an individual's overall well-being. Engagement in physical activities may vary across different ages, gender, and the capability of an individual to participate.  Despite the many potential benefits, the uptake of the level of physical activities among individuals is quite low and risk may occur that depends on the environment they are in. To elucidate these benefits and factors of physical activity engagement of individuals, this study aimed to classify all the scope of the evidence that pertains to participation in physical activities. The literature research, conducted in 2022, employed the databases Education Resources Information Center (ERIC), PubMed, ScienceDirect, and the search engine Google Scholar. Twenty-nine studies mentioning the engagement of individuals in physical activities were tagged from 4 databases.  Findings equivalent to the article and participants were summarized quantifiably, while information implying the engagement in physical activities was organized using thematic analysis. Results distinguished that level of engagement in physical activities may vary in age, gender, and capabilities. These also identified risks that may occur in too much participation in activities or not even participating. Most importantly, physical activities were beneficial to an individual's physiological, personal, and psychosocial aspects. Understanding the engagement and establishment of community-based activities with the characteristics of inclusivity that will increase the level of engagement and participation of every individual may be functional to increase the promotion of physical activities regardless of their age, gender, and capabilities to perform.
A Case Study on Philippine Sustainable Enterprises Aligned with the Quantum Sustainable Organizing Theory (QSOT)
Authors: Cheng Angelique C. Blasa , Chiu Rhett M. , Dy Catherine M. , Kim Su Jin , Trono Paul D. , Aure Patrick Adiel H. , Vergara Raymond Allan
Published: September 2023

The research aims to build on Dyck and Greidanus’ (2016) study on the Quantum Sustainable Organizing Theory (QSOT) by analyzing Philippine sustainable enterprises and how they adopt and execute the principles of QSOT into their organization. The data gathered from the multiple-case study were collated and used to promote sustainability and build knowledge on the contemporary theory. The research utilized a qualitative embedded multiple-case study design in investigating the exhibition of QSOT in Philippine sustainable enterprises.

Through in-depth interviews with three (3) Philippine sustainable enterprises or potentially QSOT organizations, the paper identified and illustrated QSOT-aligned business practices, operations, and functions. Among the three Philippine sustainable enterprises studied, two were identified as fully QSOT-oriented companies. The researchers note that QSOT can be operationalized in the country; however, the success of adoption and integration is dependent on the industry, ability to innovate the business structure, entanglement of “external” entities, and financial capacity.

The study framed sustainable organizing practices in a manner that is concrete and specific—practices that enhance social and ecological well-being were elaborated. As the Quantum Sustainable Organizing Theory (QSOT) is a contemporary theory, more research is needed to understand the concept, especially in the Philippine context.
Análise comparativa de custo e de construtibilidade em projeto de habitação de interesse social
Authors: Abreu João Paulo Maciel de , Corrêa Leonardo de Aguiar , Marchiori Fernanda Fernandes , Pieniz Luiz Augusto Ferreira
Published: September 2023

Empreendimentos de Habitação de Interesse Social (HIS) são parte de políticas públicas de habitação, e possuem características particulares, como a necessidade de menor custo e atender a condições mínimas de conforto a famílias de baixa renda. Para que o menor custo seja atendido, é necessário que os projetos sejam desenvolvidos de modo a permitir uma maior eficiência durante a execução (maior construtibilidade). O objetivo da presente pesquisa é fazer o comparativo custo versus construtibilidade para dois processos construtivos muito frequentes nas obras de HIS multifamiliares do Brasil: Alvenaria Estrutural e Paredes de Concreto Armado moldado in loco, a fim de responder à questão: o processo construtivo com melhor construtibilidade também apresenta um custo menor? Para fazer tal análise, desenvolveram-se orçamentos referentes a cada estado brasileiro e avaliações de construtibilidade para cada processo construtivo. Como resultados, verifica-se que o processo de paredes de concreto armado moldado in loco foi o que apresentou melhor construtibilidade e também o menor custo.
Procedimentos odontológicos e processos judiciais: um panorama do Estado do Rio de Janeiro
Authors: Gomes Marcela Boris Castilho , Pinto Paulo Henrique Viana , Silva Ricardo Henrique Alves da
Published: September 2023

O objetivo deste artigo foi realizar um levantamento das ações judiciais de responsabilidade civil que envolveram questionamentos de procedimentos odontológicos ajuizadas contra cirurgiões-dentistas no Estado do Rio de Janeiro, Brasil, entre os anos de 2015 e 2019. Foi realizada uma consulta dos nomes dos cirurgiões-dentistas inscritos no Estado do Rio de Janeiro com base na listagem pública de profissionais disponibilizada no sítio eletrônico do Conselho Federal de Odontologia. Para o levantamento das ações judiciais, o nome de cada profissional foi pesquisado no sítio eletrônico do Tribunal de Justiça do Estado Rio de Janeiro. Realizada a leitura de cada ação judicial, informações como o número total de processos que envolviam cirurgiões-dentistas e o quantitativo de processos por especialidade foram levantadas. Os dados foram organizados em planilhas digitais e submetidos a análise estatística descritiva. Verificou-se um total de 33.497 profissionais cadastrados, dos quais 415 estavam envolvidos em 393 processos. Procedimentos de implantodontia (n=216), endodontia (n=103) e ortodontia (n=31) foram os mais questionados nas ações judiciais. Concluiu-se que houve aumento no número de processos contra cirurgiões-dentistas no Estado do Rio de Janeiro, sendo a implantodontia a especialidade mais acionada.
Preservação do patrimônio urbano por termografia passiva: estudo em fachadas de cerâmica em Belo Horizonte
Authors: Alvarenga Cristiane  do Bom Conselho Sales , Caldas Rodrigo Barreto , Sátiro Débora Escárlate Antunes , Aguilar Maria Teresa  Paulino de , Sales Rosemary  do Bom Conselho
Published: September 2023

Belo Horizonte é uma cidade com expressivo número de fachadas revestidas em cerâmica devido à forte influência europeia e americana, o que torna a cidade um importante patrimônio urbano. No entanto, esse patrimônio é constantemente ameaçado pelo surgimento de patologias ao longo da sua vida útil. As mais comuns são a perda de aderência e as infiltrações. Para identificar tais patologias, são utilizadas técnicas destrutivas que danificam a fachada. Uma técnica não destrutiva capaz de detectar defeitos em grandes áreas seria a termografia infravermelha, que capta a radiação térmica emitida pelas superfícies dos materiais. Neste artigo, utilizou-se a termografia passiva para inspecionar fachadas submetidas à insolação direta em diferentes horários. Um modelo experimental foi construído para controle e cinco fachadas com idades diferentes foram avaliadas. Os dados indicam que a termografia permite distinguir descolamentos pontuais e/ou generalizados. Foi possível identificar a umidade, a presença de isolamento térmico, assim como a influência das cores e do tipo de material. Também se verificou a interferência de condições ambientais (horário de medição e nebulosidade) nos dados coletados.
Textura e material no pensamento musical contemporâneo
Authors: Brandão Luigi , Jara Alejandro , Bosseur Jean-Yves
Published: September 2023

A palavra textura designa, segundo a definição do dicionário Robert, a disposição dos fios de uma coisa tecida, aplicando-se naturalmente aos princípios da tecelagem e, por extensão, pode concernir à disposição (arrangement) de elementos sonoros.No vocabulário musical, o termo textura é pouco frequente e em geral ignorado pelos dicionários especializados; essa noção ocupa, entretanto, um lugar determinante na reflexão de um grande número de compositores desde os anos cinquenta. Permitindo considerar especialmente por um prisma novo as questões de timbre e a concepção da escrita orquestral, ela será examinada sucessivamente nas obras de Ligeti, Lutoslawski, Brown, Carter, Feldman e através do percurso eletroacústico.
Ansiedade na Performance Musical: estudo de caso no coro da Escola Superior de Educação
Authors: Almeida Ana Beatriz , Hiney Aoife
Published: September 2023

O presente estudo tem como objetivo principal analisar os níveis de ansiedade na performance musical dos participantes de um coro académico inserido na Licenciatura em Educação Musical da Escola Superior de Educação do Politécnico do Porto. A literatura académica aponta para uma escassez de estudos sobre a ansiedade musical entre cantores e em particular entre cantores em coros. Além disso, em semelhança com outras práticas de canto coral em Portugal, faltam estudos sistemáticos sobre coros académicos. Um estudo de caso foi realizado com o coro da Escola Superior de Educação (ESE) no qual foram recolhidos dados sociodemográficos para caracterizar os participantes do coro. O questionário State-Trait Anxiety Inventory (STAI) foi aplicado em dois momentos para medir os níveis de ansiedade traço e ansiedade estado. Os resultados do STAI correlacionam com estudos existentes quanto à ligação entre a ansiedade e o género, enquanto outros fatores como por exemplo o papel de solista não teve impactos estatisticamente significativos. Entretanto, o questionário sociodemográfico revela a heterogeneidade dos alunos que frequentam a licenciatura em Educação Musical na Escola Superior de Educação (ESE), principalmente em relação à idade e a prática instrumental.
Canta, canta, minha gente: uma revisão de literatura sobre o coro infantojuvenil nos anais dos Congressos Nacionais da ABEM
Authors: Andrade Klesia Garcia , Paz Anaide Maria Alves da , Pereira Valdiene Carneiro
Published: September 2023

O artigo apresenta dados parciais de uma revisão de literatura, de caráter sistemática e autônoma, que tem por objetivo geral compreender o que os conteúdos das revistas e dos anais da ABEM e da ANPPOM revelam sobre a prática coral infantojuvenil. Os resultados discutidos dizem respeito aos conteúdos dos artigos publicados em 15 anais dos Congressos Nacionais da ABEM, realizados no período de 2001 a 2019. A revisão foi organizada em duas etapas distintas. A primeira ocupou-se do levantamento e identificação dos artigos e a segunda, em andamento, da leitura e análise dos conteúdos. A análise dos artigos orienta-se por um roteiro cujos dados são discutidos em reuniões semanais entre as pesquisadoras. Considerando a complexidade que permeia o uso de determinadas terminologias no universo do canto coral, foram delineadas concepções sobre os termos coro, infantojuvenil e prática coral. Tais concepções colaboraram na definição de critérios de inclusão e exclusão de artigos para a revisão. Dos 2753 artigos publicados nos referidos anais, um total de 37 publicações trazem discussões sobre o coro infantojuvenil. Através de seis categorias de análise evidenciamos os destaques e a predominância de temas debatidos, além de lacunas de assuntos pouco explorados. O percurso crítico, de trabalho exaustivo e rigoroso com a revisão da área poderá fornecer um quadro geral, norteando estudos e trazendo reflexões sobre os caminhos passíveis de serem trilhados no âmbito das produções acadêmicas sobre o coro infantojuvenil.
Physiological Mechanisms of Dietary Salt Sensing in the Brain, Kidney, and Gastrointestinal Tract
Authors: Stocker Sean D. , Kinsman Brian J. , Farquhar William B. , Gyarmati Georgina , Peti-Peterdi Janos , Sved Alan F.
Published: September 2023

Excess dietary salt (NaCl) intake is strongly correlated with cardiovascular disease and is a major contributing factor to the pathogenesis of hypertension. NaCl-sensitive hypertension is a multisystem disorder that involves renal dysfunction, vascular abnormalities, and neurogenically-mediated increases in peripheral resistance. Despite a major research focus on organ systems and these effector mechanisms causing NaCl-induced increases in arterial blood pressure, relatively less research has been directed at elucidating how NaCl is sensed by various tissues to elicit these downstream effects. The purpose of this review is to discuss how the brain, kidney, and gastrointestinal tract sense NaCl including key cell types, the role of NaCl versus osmolality, and the underlying molecular and electrochemical mechanisms.
Maternal First-Trimester Alpha-Fetoprotein and Placenta-Mediated Pregnancy Complications
Authors: Melamed Nir , Okun Nanette , Huang Tianhua , Mei-Dan Elad , Aviram Amir , Allen Melinda , Abdulaziz Kasim E. , McDonald Sarah D. , Murray-Davis Beth , Ray Joel G. , Barrett Jon , Kingdom John , Berger Howard ,   for DOH-NET (Diabetes, Obesity and Hypertension in Pregnancy Research Network) and SOON (Southern Ontario Obstetrical Network) Investigators
Published: September 2023

BACKGROUND:

Maternal serum markers used for trisomy 21 screening are associated with placenta-mediated complications. Recently, there has been a transition from the traditional first-trimester screening (FTS) that included PAPP-A (pregnancy-associated plasma protein-A) and beta-hCG (human chorionic gonadotropin), to the enhanced FTS test, which added first-trimester AFP (alpha-fetoprotein) and PlGF (placental growth factor). However, whether elevated first-trimester AFP has a similar association with placenta-mediated complications to that observed for elevated second-trimester AFP remains unclear. Our objective was to estimate the association of first-trimester AFP with placenta-mediated complications and compare it with the corresponding associations of second-trimester AFP and other first-trimester serum markers.

METHODS:

Retrospective population-based cohort study of women who underwent trisomy 21 screening in Ontario, Canada (2013–2019). The association of first-trimester AFP with placenta-mediated complications was estimated and compared with that of the traditional serum markers. The primary outcome was a composite of stillbirth or preterm placental complications (preeclampsia, birthweight less than third centile, or placental abruption).

RESULTS:

A total of 244 990 and 96 167 women underwent FTS and enhanced FTS test screening, respectively. All markers were associated with the primary outcome, but the association for elevated first-trimester AFP (adjusted relative risk [aRR], 1.57 [95% CI, 1.37–1.81]) was weaker than that observed for low PAPP-A (aRR, 2.48 [95% CI, 2.2–2.8]), low PlGF (aRR, 2.28 [95% CI, 1.97–2.64]), and elevated second-trimester AFP (aRR, 1.97 [95% CI, 1.81–2.15]). When the models were adjusted for all 4 enhanced FTS test markers, elevated first-trimester AFP was no longer associated with the primary outcome (aRR, 0.77 [95% CI, 0.58–1.02]).

CONCLUSIONS:

Unlike second-trimester AFP, elevated first-trimester AFP is not an independent risk factor for placenta-mediated complications.
Racial Disparities in Obesity‐Related Cardiovascular Mortality in the United States: Temporal Trends From 1999 to 2020
Authors: Raisi‐Estabragh Zahra , Kobo Ofer , Mieres Jennifer H. , Bullock‐Palmer Renee P. , Van Spall Harriette G.C. , Breathett Khadijah , Mamas Mamas A.
Published: September 2023

Background

Obesity is a major risk factor for cardiovascular disease, with differential impact across populations. This descriptive epidemiologic study outlines trends and disparities in obesity‐related cardiovascular mortality in the US population between 1999 and 2020.

Methods and Results

The Multiple Cause of Death database was used to identify adults with primary cardiovascular death and obesity recorded as a contributing cause of death. Cardiovascular deaths were grouped into ischemic heart disease, heart failure, hypertensive disease, cerebrovascular disease, and other. Absolute, crude, and age‐adjusted mortality rates (AAMRs) were calculated by racial group, considering temporal trends and variation by sex, age, and residence (urban versus rural). Analysis of 281 135 obesity‐related cardiovascular deaths demonstrated a 3‐fold increase in AAMRs from 1999 to 2020 (2.2‐6.6 per 100 000 population). Black individuals had the highest AAMRs. American Indian or Alaska Native individuals had the greatest temporal increase in AAMRs (+415%). Ischemic heart disease was the most common primary cause of death. The second most common cause of death was hypertensive disease, which was most common in the Black racial group (31%). Among Black individuals, women had higher AAMRs than men; across all other racial groups, men had a greater proportion of obesity‐related cardiovascular mortality cases and higher AAMRs. Black individuals had greater AAMRs in urban compared with rural settings; the reverse was observed for all other races.

Conclusions

Obesity‐related cardiovascular mortality is increasing with differential trends by race, sex, and place of residence.
Intensive Statin Therapy Versus Upfront Combination Therapy of Statin and Ezetimibe in Patients With Acute Coronary Syndrome: A Propensity Score Matching Analysis Based on the PL‐ACS Data
Authors: Lewek Joanna , Niedziela Jacek , Desperak Piotr , Dyrbuś Krzysztof , Osadnik Tadeusz , Jankowski Piotr , Witkowski Adam , Bielecka‐Dąbrowa Agata , Dudek Dariusz , Gierlotka Marek , Gąsior Mariusz , Banach Maciej
Published: September 2023

Background

We aimed to compare statin monotherapy and upfront combination therapy of statin and ezetimibe in patients with acute coronary syndromes (ACSs).

Methods and Results

The study included consecutive patients with ACS included in the PL‐ACS (Polish Registry of Acute Coronary Syndromes), which is a national, multicenter, ongoing, prospective observational registry that is mandatory for patients with ACS hospitalized in Poland. Data were matched using the Mahalanobis distance within propensity score matching calipers. Multivariable stepwise logistic regression analysis, including all variables, was next used in propensity score matching analysis. Finally, 38 023 consecutive patients with ACS who were discharged alive were included in the analysis. After propensity score matching, 2 groups were analyzed: statin monotherapy (atorvastatin or rosuvastatin; n=768) and upfront combination therapy of statin and ezetimibe (n=768 patients). The difference in mortality between groups was significant during the follow‐up and was present at 1 (5.9% versus 3.5%;
P
=0.041), 2 (7.8% versus 4.3%;
P
=0.019), and 3 (10.2% versus 5.5%;
P
=0.024) years of follow‐up in favor of the upfront combination therapy, as well as for the overall period. For the treatment, rosuvastatin significantly improved prognosis compared with atorvastatin (odds ratio [OR], 0.790 [95% CI, 0.732–0.853]). Upfront combination therapy was associated with a significant reduction of all‐cause mortality in comparison with statin monotherapy (OR, 0.526 [95% CI, 0.378–0.733]), with absolute risk reduction of 4.7% after 3 years (number needed to treat=21).

Conclusions

The upfront combination lipid‐lowering therapy is superior to statin monotherapy for all‐cause mortality in patients with ACS. These results suggest that in high‐risk patients, such an approach, rather than a stepwise therapy approach, should be recommended.
MIRACL: A Multilingual Retrieval Dataset Covering 18 Diverse Languages
Authors: Zhang Xinyu , Thakur Nandan , Ogundepo Odunayo , Kamalloo Ehsan , Alfonso-Hermelo David , Li Xiaoguang , Liu Qun , Rezagholizadeh Mehdi , Lin Jimmy
Published: September 2023

MIRACL is a multilingual dataset for ad hoc retrieval across 18 languages that collectively encompass over three billion native speakers around the world. This resource is designed to support monolingual retrieval tasks, where the queries and the corpora are in the same language. In total, we have gathered over 726k high-quality relevance judgments for 78k queries over Wikipedia in these languages, where all annotations have been performed by native speakers hired by our team. MIRACL covers languages that are both typologically close as well as distant from 10 language families and 13 sub-families, associated with varying amounts of publicly available resources. Extensive automatic heuristic verification and manual assessments were performed during the annotation process to control data quality. In total, MIRACL represents an investment of around five person-years of human annotator effort. Our goal is to spur research on improving retrieval across a continuum of languages, thus enhancing information access capabilities for diverse populations around the world, particularly those that have traditionally been underserved. MIRACL is available at http://miracl.ai/.
A Human Rights-Based Approach to Combating Corruption in the Education Sector in Indonesia
Authors: Juwita Ratna
Published: September 2023

The education sector is prone to corruption because of the substantial amount of allocated funds and complex administrative layers that govern it. This article discusses the human rights-based approach to analyse corruption in the education sector in Indonesia. The data concerning education sector corruption are based on the judgment collection from the Corruption Eradication Commission Annual Reports from 2004 to 2018. Education sector corruption is classified into three types: grand corruption in procurement projects, obstruction of justice, and corruption related to decentralisation. The analysis showed that Indonesia’s efforts to realise the right to education cannot be achieved effectively and efficiently due to corruption. The human rights approach is used to formulate recommendations to combat education sector corruption to successfully realise the right to education. This article recommends that Indonesia must ensure the implementation of transparency and accountability in law, policy, and governance because corruption thrives where the State’s monopoly of power and discretion exists without accountability and transparency.
A new genus of Heterocampinae (Lepidoptera, Notodontidae) from Central and South America
Authors: St Laurent Ryan A. , Goldstein Paul Z. , Robbins Robert K.
Published: September 2023

We propose the name Millerocampa gen. n. in the Notodontidae (Heterocampinae) for Central and South American species. The species in this genus were originally described in the notodontid genus Cerura (Cerurinae) due to reflective white scales and black zigzagging patterns on the forewing dorsum, which are usually indicative of Cerurinae. However, based on recent phylogenomic data and morphological analyses, it has been shown that three names recently placed in the Heterocampinae genus Tecmessa belong to a relatively unrelated Heterocampinae genus Millerocampa gen. n., resulting in the following new combinations: Millerocampa gonema (Schaus), comb. n., type species of Millerocampa, and Millerocampa laqueata (Schaus), comb. n. The name Cerura olindata syn. n. is a synonym of M. gonema. Images of male and female adults, including all types, and genitalia of both recognized species of Millerocampa are presented.
Shifting Attitudes to Drinking Common Water in Dutch Medicine, 1630–1750
Authors: Pierik Bob
Published: September 2023

The idea that water-drinking is healthy took shape in medical science throughout Europe from the seventeenth century onwards. This article adds new insights to this development through a focus on the Dutch field of medicine between 1630 and 1750. It shows how a major scientific context for this shift could be found in the specific combination of Helmontian iatrochemistry and Cartesian medicine. Yet, the development of thinking about drinking water was also very much shaped by social practices and technological advances outside of medicine. Chronologically, the increased social practice of the capture of rainwater and the technological improvements of cisterns and filtration systems in the seventeenth century precede the more positive medical opinion on water in the late seventeenth and early eighteenth century. The idea that water-drinking was beneficial came into medicine through social practice, rather than the other way around. In the eighteenth century, water-drinking was seen as beneficial in the mainstream of medicine, with explicit references being made to earlier technological advances in filtration.