bluuebunny/crossref_metadata_2025 huggingface dataset:
Random Power Series in

Q

p
,
0

Spaces
Authors: Li Haiyin , Wu Yan
Published: October 2021

Aulaskari et al. proved if

0
<
p
<
1

and

ε

n

is sequence of independent, identically distributed Rademacher random variables on a probability space, then the condition

Σ

n
=
0

∞

n

1
−
p

a

n

2

<
∞

implies that the random power series

R
f

z

=

∑

n
=
0

∞

a

n

ε

n

z

n

∈

Q

p

almost surely. In this paper, we improve this result showing that the condition

Σ

n
=
0

∞

n

1
−
p

a

n

2

<
∞

actually implies

R
f
∈

Q

p
,
0

almost surely.
Jie‐Yu‐He‐Huan Capsule Ameliorates Anxiety‐Like Behaviours in Rats Exposed to Chronic Restraint Stress via the cAMP/PKA/CREB/BDNF Signalling Pathway
Authors: Geng Xiwen , Wu Hongyun , Li Zifa , Li Chuanfen , Chen Dan , Zong Jiancheng , Liu Zimin , Wei Sheng , Peng Wei
Published: October 2021

Chronic stress is a critical factor in the aetiology of anxiety disorders; however, in the clinic, enduring and preventive measures are not available, and therapeutic drugs are associated with inevitable side effects. Our study established an anxiety rat model using chronic restraint stress (CRS) and assessed these animals using the open‐field test, elevated plus‐maze test, and light‐dark box test. Jie‐Yu‐He‐Huan capsule (JYHH), a Chinese medicine formula, was used as a preventative drug. The HPA axis‐mediated release of corticotropin‐releasing hormone, adrenocorticotropic hormone, and corticosterone from the hypothalamus was tested. In the hippocampus and prefrontal cortex, concentrations of 5‐HT and its metabolite 5‐hydroxyindoleacetic acid, as well as monoamine oxidase A, glucocorticoid receptor, and 5‐HT1A receptor expression levels, were measured. Furthermore, we examined protein and mRNA expression of cAMP‐PKA‐CREB‐BDNF pathway components. The results showed that JYHH had a significant preventative effect on the anxiety‐like behaviour induced by CRS and prevented abnormal changes in the HPA axis and 5‐HT system. Furthermore, CRS inhibited the cAMP‐PKA‐CREB‐BDNF pathway, which returned to normal levels following JYHH treatment. This might be the underlying molecular mechanism of the antianxiety effect of JYHH, which could provide a new clinical target for preventative anxiolytic drugs for chronic stress.
Antifungal Activity and Major Bioactive Compounds of Water Extract of Pangium edule Seed against Aspergillus flavus
Authors: Listyorini Kharisma I. , Kusumaningrum Harsi D. , Lioe Hanifah N.
Published: October 2021

Pangium edule seeds are widely used as spices in Southeast Asia in a fresh and fermented form and are reported to have active compounds for food preservation. However, scientific data on the active compounds of P. edule seed that can prevent the growth of toxigenic Aspergillus flavus have not been widely reported. This research subjected to determine the antifungal activity and identify the active compounds of water extract of old and fermented seed of P. edule against A. flavus. The water extract was compared to the extracts obtained by multilevel maceration using 50% ethanol, ethyl acetate, and n-hexane as solvents. Alkaloid, saponin, phenolic compound, flavonoid, triterpenoid, and glycoside were detected qualitatively in the crude extracts. The water extract showed the best activity to suppress the growth of A. flavus, determined by the agar dilution method, with the minimum inhibitory concentration (MIC) of 12.5 and 25 mg/mL for old and fermented seed, respectively. The water extracts showed a moderate toxicity with LC50 of 100-500 μg/mL, determined by the brine-shrimp toxicity test. After fractionation using 3 kDa molecular-weight (MW) cut-off ultrafiltration membrane, two fractions, i.e., fraction with

MW
<
3

 kDa and >3 kDa, were obtained. The fraction with

MW
<
3

 kDa showed the best antifungal activity with the MIC of 6.25 and 12.5 mg/mL for old and fermented seed, respectively. LC-MS/MS profile showed that different compounds belong to fatty acid, amino acid, glycoside, and peptide were found as major active compounds in the fractionated water extract. The principal compounds and partial least-square analysis, however, suggested that fatty acid and glycoside are responsible for the antifungal activity. Hence, this study concluded that the water extract of P. edule seed had promising antifungal activity against A. flavus which was due to presence of particular compounds belong to fatty acid and glycoside.
The Impact of PTPRK and ROS1 Polymorphisms on the Preeclampsia Risk in Han Chinese Women
Authors: Li Huihui , Yan Xingyu , Yang Man , Liu Mei , Tian Shan , Yu Mengru , Li Wei-Ping , Zhang Cong
Published: October 2021

Objective. Preeclampsia (PE) is a severe complication in pregnancy and a leading cause of maternal and infant mortality. However, the exact underlying etiology of PE remains unknown. Emerging evidence indicates that the cause of PE is associated with genetic factors. Therefore, the aim of this study is to identify susceptibility genes to PE. Materials and Methods. Human Exome BeadChip assays were conducted using 370 cases and 482 controls and 21 loci were discovered. A further independent set of 958 cases and 1007 controls were recruited for genotyping to determine whether the genes of interest ROS1 and PTPRK are associated with PE. Immunohistochemistry was used for localization. Both qPCR and Western blotting were utilized to investigate the levels of PTPRK in placentas of 20 PE and 20 normal pregnancies. Results. The allele frequency of PTPRK rs3190930 differed significantly between PE and controls and was particularly significant in severe PE subgroup and early-onset PE subgroup. PTPRK is primarily localized in placental trophoblast cells. The mRNA and protein levels of PTPRK in PE were significantly higher than those in controls. Conclusion. These results suggest that PTPRK appears to be a previously unrecognized susceptibility gene for PE in Han Chinese women, and its expression is also associated with PE, while ROS1 rs9489124 has no apparent correlation with PE risk.
Design Optimization and Burst Speed Prediction of a Ti2AlNb Blisk
Authors: Guo Yue , Liu Yi-xiong , Wu Yun-wu , Cao Hang , Mo Da
Published: October 2021

The increasing demand for power, fuel efficiency, and safety of aeroengines has called for weight reduction and structural integrity examination of the critical components. This paper is aimed at performing a systematic investigation on the design of a high-speed Ti2AlNb blisk, including disc geometry optimization and burst speed prediction. Incorporating the design of the experimental approach and the commercial software has guaranteed that the optimization could be accomplished. Six key parameters were defined as variables with regard to the geometric dimensions whereas the safety factors were set as constraints to make the disc feasible. Sensitivity analysis has been conducted to study the effects of the variables on the safety factors and disc weight. Bore width, web width, and bore angle are identified to be the dominant factors regarding optimization. Results reveal that the bore width and web width are positively related to the safety factors at the cost of increasing the disc weight. On the contrary, the effects of the bore angle show the opposite trend. Finally, the achieved minimum disc weight is 15.2 kg with all the safety factors meeting the requirements. Upon completing the disc shape optimization, the burst speed was estimated using three elaborated methods. The comparisons between the numerical results and the experimental results indicate that the mean stress method is accurate when the correction coefficient is chosen properly. The local stress and strain method and the global plastic instability method also offer a precise prediction on the burst speed with errors of less than 5%. It could also be concluded that the predicted web failure in the radial direction of the disc is in good agreement with the experimental results.
Beta3‐Adrenergic Receptor Activation Alleviates Cardiac Dysfunction in Cardiac Hypertrophy by Regulating Oxidative Stress
Authors: Zhang Mingming , Xu Yuerong , Chen Jianghong , Qin Chaoshi , Liu Jing , Guo Dong , Wang Rui , Hu Jianqiang , Zou Qing , Yang Jingxiao , Wang Zikuan , Niu Xiaolin
Published: October 2021

Background. Excessive myocardial oxidative stress could lead to the congestive heart failure. NADPH oxidase is involved in the pathological process of left ventricular (LV) remodeling and dysfunction. β3‐Adrenergic receptor (AR) could regulate cardiac dysfunction proved by recent researches. The molecular mechanism of β3‐AR regulating oxidative stress, especially NADPH oxidase, remains to be determined. Methods. Cardiac hypertrophy was constructed by the transverse aortic constriction (TAC) model. ROS and NADPH oxidase subunits expression were assessed after β3‐AR agonist (BRL) or inhibitor (SR) administration in cardiac hypertrophy. Moreover, the cardiac function, fibrosis, heart size, oxidative stress, and cardiomyocytes apoptosis were also detected. Results. β3‐AR activation significantly alleviated cardiac hypertrophy and remodeling in pressure‐overloaded mice. β3‐AR stimulation also improved heart function and reduced cardiomyocytes apoptosis, oxidative stress, and fibrosis. Meanwhile, β3‐AR stimulation inhibited superoxide anion production and decreased NADPH oxidase activity. Furthermore, BRL treatment increased the neuronal NOS (nNOS) expression in cardiac hypertrophy. Conclusion. β3‐AR stimulation alleviated cardiac dysfunction and reduced cardiomyocytes apoptosis, oxidative stress, and fibrosis by inhibiting NADPH oxidases. In addition, the protective effect of β3‐AR is largely attributed to nNOS activation in cardiac hypertrophy.
Osteolysis: A Literature Review of Basic Science and Potential Computer‐Based Image Processing Detection Methods
Authors: Saadi Soroush Baseri , Ranjbarzadeh Ramin , Ozeir kazemi  , Amirabadi Amir , Ghoushchi Saeid Jafarzadeh , Kazemi Oveis , Azadikhah Sonya , Bendechache Malika
Published: October 2021

Osteolysis is one of the most prominent reasons of revision surgeries in total joint arthroplasty. This biological phenomenon is induced by wear particles and corrosion products that stimulate inflammatory biological response of surrounding tissues. The eventual responses of osteolysis are the activation of macrophages leading to bone resorption and prosthesis failure. Various factors are involved in the initiation of osteolysis from biological issues, design, material specifications, and model of the prosthesis to the health condition of the patient. Nevertheless, the factors leading to osteolysis are sometimes preventable. Changes in implant design and polyethylene manufacturing are striving to improve overall wear. Osteolysis is clinically asymptomatic and can be diagnosed and analyzed during follow‐up sessions through various imaging modalities and methods, such as serial radiographic, CT scan, MRI, and image processing‐based methods, especially with the use of artificial neural network algorithms. Deep learning algorithms with a variety of neural network structures such as CNN, U‐Net, and Seg‐UNet have proved to be efficient algorithms for medical image processing specifically in the field of orthopedics for the detection and segmentation of tumors. These deep learning algorithms can effectively detect and analyze osteolytic lesions well in advance during follow‐up sessions in order to administer proper treatments before reaching a critical point. Osteolysis can be treated surgically or nonsurgically with medications. However, revision surgeries are the only solution for the progressive osteolysis. In this literature review, the underlying causes, mechanisms, and treatments of osteolysis are discussed with the main focus on the possible computer‐based methods and algorithms that can be effectively employed for the detection of osteolysis.
A Novel Method for Integration of Online Educational Resources via Teaching Information Remote Scheduling
Authors: Zhao Kang
Published: October 2021

The traditional online education resource integration technology ignores the calculation of the characteristic variance contribution rate of online educational resources, and the evaluation of educational resources is biased, which leads to the low ability of resource integration. Therefore, the online education resource integration technology based on remote scheduling of teaching information is proposed. Based on the theory of remote scheduling of teaching information, the quantitative value of online educational resources integration is obtained. By calculating the integration probability of online educational resources, the influencing factors of online educational resources in the process of integration are determined. The principle of teaching information remote scheduling is integrated into the feature vector extraction of online educational resources, and the contribution rate of feature variance of online educational resources is calculated. By extracting the number of main factors of the online educational resources feature vector, the feature vector of online educational resources is decomposed. Taking the wavelet entropy of online educational resources as the fusion weight of online educational resources, the integration result of online educational resources is obtained through wavelet transform. The experimental results show that the online education resource integration technology based on remote scheduling of teaching information has ideal application performance in integration probability, the goodness of fit, and robustness.
[Retracted] Innovative Styling and Structural Design of New Duplex Wide‐Body Passenger Aircraft Based on Mobile Edge Computing
Authors: Chen Lu , Xu Lijun , Yang Qinghan , Pan Xinke
Published: October 2021

The research is designed to explore wide‐body aircraft that are more suitable in 2035‐2040. The innovative design of the wide‐body aircraft adopts the form of the main passenger compartment and wing separation, the passenger compartment in the form of a single engine car through the rail transit and transfer car travel together. The transfer car delivers the two engine cars in turn to the aircraft, which is tightly connected to the rail structure by mechanical claws. Engine cars can split up at the transfer station, thus assisting in the diversion of passengers. The interior of the engine car has been optimized. A visual mask can be used for isolation has been designed for the seats. And a device is designed to lighten passengers’ legs to alleviate “economy class syndrome.” The corresponding data analysis used the mobile edge computing technology.
Analyzing mRNAsi-Related Genes Identifies Novel Prognostic Markers and Potential Drug Combination for Patients with Basal Breast Cancer
Authors: Huang Kai , Wu Yu , Xie YunQing , Huang LiYing , Liu Hong
Published: October 2021

Basal breast cancer subtype is the worst prognosis subtypes among all breast cancer subtypes. Recently, a new tumor stemness index-mRNAsi is found to be able to measure the degree of oncogenic differentiation of tissues. The mRNAsi involved in a variety of cancer processes is derived from the innovative application of one-class logistic regression (OCLR) machine learning algorithm to the whole genome expression of various stem cells and tumor cells. However, it is largely unknown about mRNAsi in basal breast cancer. Here, we find that basal breast cancer carries the highest mRNAsi among all four subtypes of breast cancer, especially 385 mRNAsi-related genes are positively related to the high mRNAsi value in basal breast cancer. This high mRNAsi is also closely related to active cell cycle, DNA replication, and metabolic reprogramming in basal breast cancer. Intriguingly, in the 385 genes, TRIM59, SEPT3, RAD51AP1, and EXO1 can act as independent protective prognostic factors, but CTSF and ABHD4B can serve as independent bad prognostic factors in patients with basal breast cancer. Remarkably, we establish a robust prognostic model containing the 6 mRNAsi-related genes that can effectively predict the survival rate of patients with the basal breast cancer subtype. Finally, the drug sensitivity analysis reveals that some drug combinations may be effectively against basal breast cancer via targeting the mRNAsi-related genes. Taken together, our study not only identifies novel prognostic biomarkers for basal breast cancers but also provides the drug sensitivity data by establishing an mRNAsi-related prognostic model.
Optimization of Growth Conditions and Biological Activities of Nepalese Ganoderma lucidum Strain Philippine
Authors: Subedi Krishna , Basnet Buddha Bahadur , Panday Raju , Neupane Manisha , Tripathi Giri Raj
Published: October 2021

Ganoderma lucidum has been extensively studied for its valuable medicinal importance. In this study, the artificial cultivation of G. lucidum strain Philippine in different culture media, including sawdust substrate, was performed and optimized on the Potato Dextrose Agar (PDA) media. Phytochemical, antibacterial, and antioxidant analyses were performed and compared between the ethanol extracts prepared from two different cultures (fruit from synthetic log culture and mycelia from PDA media culture). Both the 200 mg/mL and 100 mg/mL concentrations of extracts inhibited all the tested bacteria, and the results were promising than the corresponding control using antibiotics. The fruit extract showed higher antioxidant potential (150.6 ± 56.92 mg ascorbic acid equivalent/g extract) than mycelial extract (144.28 ± 81.72 mg ascorbic acid equivalent/g extract). The results indicate that fruiting bodies of G. lucidum cultivated in a complex dust medium possess higher antioxidant properties than mycelia culture, which can be further explored for therapeutic applications.
A Study of Doubly Warped Product Immersions in a Nearly Trans-Sasakian Manifold with Slant Factor
Authors: Alkhaldi Ali H. , Siddiqui Aliya Naaz , Ahmad Kamran , Ali Akram
Published: October 2021

In this article, we discuss the de Rham cohomology class for bislant submanifolds in nearly trans-Sasakian manifolds. Moreover, we give a classification of warped product bislant submanifolds in nearly trans-Sasakian manifolds with some nontrivial examples in the support. Next, it is of great interest to prove that there does not exist any doubly warped product bislant submanifolds other than warped product bislant submanifolds in nearly trans-Sasakian manifolds. Some immediate consequences are also obtained.
Applications of Deep Learning Techniques for Pedestrian Detection in Smart Environments: A Comprehensive Study
Authors: He Fen , Karami Olia Paria , Jamili Oskouei Rozita , Hosseini Morteza , Peng Zhihao , BaniRostam Touraj
Published: October 2021

Intelligent transportation systems have been very well received by car companies, people, and governments around the world. The main challenge in the world of smart and self-driving cars is to identify obstacles, especially pedestrians, and take action to prevent collisions with them. Many studies in this field have been done by various researchers, but there are still many errors in the accurate detection of pedestrians in self-made cars made by different car companies, so in the research in this study, we focused on the use of deep learning techniques to identify pedestrians for the development of intelligent transportation systems and self-driving cars and pedestrian identification in smart cities, and then some of the most common deep learning techniques used by various researchers were reviewed. Finally, in this research, the challenges in each field are discovered, which can be very useful for students who are looking for an idea to do their dissertations and research in the field of smart transportation and smart cities.
Metabolic Analysis of Potential Key Genes Associated with Systemic Lupus Erythematosus Using Liquid Chromatography-Mass Spectrometry
Authors: Zeng Li , Chen Nian , Liao Junlin , Shen Xu , Song Shenghua , Wang Feng
Published: October 2021

The biological mechanism underlying the pathogenesis of systemic lupus erythematosus (SLE) remains unclear. In this study, we found 21 proteins upregulated and 38 proteins downregulated by SLE relative to normal protein metabolism in our samples using liquid chromatography-mass spectrometry. By PPI network analysis, we identified 9 key proteins of SLE, including AHSG, VWF, IGF1, ORM2, ORM1, SERPINA1, IGF2, IGFBP3, and LEP. In addition, we identified 4569 differentially expressed metabolites in SLE sera, including 1145 reduced metabolites and 3424 induced metabolites. Bioinformatics analysis showed that protein alterations in SLE were associated with modulation of multiple immune pathways, TP53 signaling, and AMPK signaling. In addition, we found altered metabolites associated with valine, leucine, and isoleucine biosynthesis; one carbon pool by folate; tyrosine metabolism; arginine and proline metabolism; glycine, serine, and threonine metabolism; limonene and pinene degradation; tryptophan metabolism; caffeine metabolism; vitamin B6 metabolism. We also constructed differently expressed protein-metabolite network to reveal the interaction among differently expressed proteins and metabolites in SLE. A total of 481 proteins and 327 metabolites were included in this network. Although the role of altered metabolites and proteins in the diagnosis and therapy of SLE needs to be further investigated, the present study may provide new insights into the role of metabolites in SLE.
Serum Fetuin‐B Levels Are Elevated in Women with Metabolic Syndrome and Associated with Increased Oxidative Stress
Authors: Xue Shiyao , Han Hongdong , Rui Shunli , Yang Mengliu , Huang Yizhou , Zhan Bin , Geng Shan , Liu Hua , Chen Chen , Yang Gangyi , Li Ling
Published: October 2021

Previous studies on serum fetuin‐B (fetuin‐like protein IRL685) have investigated its association with T2DM; however, the reason for the variation in serum fetuin‐B and its regulatory factors in metabolic disease remain unclear. Here, we evaluated serum fetuin‐B levels in women with newly diagnosed MetS and performed multiple interventions to investigate the role of fetuin‐B in the pathogenesis of MetS. Serum fetuin‐B levels were assessed using ELISA. Bioinformatics analysis was performed to analyze fetuin‐B‐related genes and signaling pathways. Additionally, oxidative stress parameters were measured in the in vitro study. For subgroup analyses, we performed EHC, OGTT, and treatment with a GLP‐1RA to investigate the regulatory factors of serum fetuin‐B. We found that in comparison with healthy subjects, serum fetuin‐B levels were markedly increased in women with MetS. Further, serum fetuin‐B showed a positive correlation with WHR, FAT%, TG, FBG, HbA1c, FIns, HOMA‐IR, VAI, and LAP. Bioinformatics analysis revealed that most fetuin‐B‐related core genes were involved in cholesterol metabolism and fat decomposition. Consistent with this finding, multivariate regression analysis showed that triglyceride content and WHR were independently associated with serum fetuin‐B. We also observed that serum fetuin‐B levels were markedly elevated in healthy subjects after glucose loading and in women with MetS during EHC. In vitro, overexpression of fetuin‐B promoted oxidative stress in HepG2 cell. After 6 months of treatment with a GLP‐1RA, serum fetuin‐B levels in women with MetS decreased following an improvement in metabolism and insulin sensitivity. Therefore, serum fetuin‐B is associated with MetS, which may serve as a biomarker of oxidative stress. This trial is registered with ChiCTR-OCC-11001422.
Human-Computer Interaction Design of Intelligent Vehicle-Mounted Products Based on the Internet of Things
Authors: Wang Kang
Published: October 2021

With the development of science and technology, human-computer interaction technology has also been more applied. This article aims to use the Internet of Things technology to apply human-computer interaction technology to smart car products to improve the realism and immersion of the user's human-computer interaction experience. This paper deeply studies the concept of networking technology and frame composition and analyzes the intelligent vehicle product development strengths and weaknesses. Then, from the perspective of human-computer interaction design, the training response and training learning situation of human-computer interaction are proposed, and the human-computer interaction system of intelligent vehicle-mounted products based on the Internet of Things is constructed. The user experience is improved from this perspective, and the breadth of applications is increased. This article first analyzes and predicts the market size of smart car products and then analyzes the scene elements of car products. When designing car products, the driver's control range should be fully considered. Finally, the user's human-computer interaction experience analysis for smart car products is analyzed. In the execution of navigation and telephone tasks, there is no significant difference in user satisfaction with tasks and the

P

values are all less than 0.05.
A Metaheuristic Approach to Secure Multimedia Big Data for IoT‐Based Smart City Applications
Authors: Gill Harsimranjit Singh , Singh Tarandip , Kaur Baldeep , Gaba Gurjot Singh , Masud Mehedi , Baz Mohammed
Published: October 2021

Media streaming falls into the category of Big Data. Regardless of the video duration, an enormous amount of information is encoded in accordance with standardized algorithms of videos. In the transmission of videos, the intended recipient is allowed to receive a copy of the broadcasted video; however, the adversary also has access to it which poses a serious concern to the data confidentiality and availability. In this paper, a cryptographic algorithm, Advanced Encryption Standard, is used to conceal the information from malicious intruders. However, in order to utilize fewer system resources, video information is compressed before its encryption. Various compression algorithms such as Discrete Cosine Transform, Integer Wavelet transforms, and Huffman coding are employed to reduce the enormous size of videos. moving picture expert group is a standard employed in video broadcasting, and it constitutes of different frame types, viz., I, B, and P frames. Later, two frame types carry similar information as of foremost type. Even I frame is to be processed and compressed with the abovementioned schemes to discard any redundant information from it. However, I frame embraces an abundance of new information; thus, encryption of this frame is sufficient enough to safeguard the whole video. The introduction of various compression algorithms can further increase the encryption time of one frame. The performance parameters such as PSNR and compression ratio are examined to further analyze the proposed model’s effectiveness. Therefore, the presented approach has superiority over the other schemes when the speed of encryption and processing of data are taken into consideration. After the reversal of the complete system, we have observed no major impact on the quality of the deciphered video. Simulation results ensure that the presented architecture is an efficient method for enciphering the video information.
Use of the AFX Stent Graft in Patients with Extremely Narrow Aortic Bifurcation: A Multicenter Retrospective Study
Authors: Wagenhäuser M. U. , Floros N. , Nikitina E. , Mulorz J. , Balzer K. M. , Goulas S. , Petrich M. , Dueppers P. , Simon F. , Schelzig H. , Oberhuber A.
Published: October 2021

Introduction. This study analyzed the patient outcomes following endovascular aortic aneurysm repair (EVAR) for infrarenal aortic pathologies with very narrow aortic bifurcations using the AFX stent graft. Methods. The data was retrieved from the archived medical records of 35 patients treated for abdominal aortic aneurysm (AAA) (48.6%) or penetrating aortic ulcer (PAU) (51.4%) with very narrow aortic bifurcation between January 2013 and May 2020. Patient survival, freedom from endoleak (EL), and limb occlusion were estimated applying the Kaplan–Meier method. Results. The mean follow-up time was

20.4
±
22.8

months. The mean aortic bifurcation diameter was

15.8
±
2.2
 
mm

. Technical success was 100%, and no procedure-related deaths occurred. Two type II ELs occurred within 30-day follow-up. We observed one common iliac artery stenosis at four months and one type III EL at 54 months in the same patient, both of which required re-intervention. Overall patient survival was

95
±
5
%

(AAA: 100%; PAU:

89
±
10
%

), freedom from limb occlusion was

94
±
5
%

(AAA:

91
±
9
%

; PAU: 100%), freedom from type II EL was

94
±
4
%

(AAA:

88
±
8
%

; PAU: 100%), and freedom from EL type III was

83
±
15
%

(AAA:

80
±
18
%

; PAU: 100%) at the end of the follow-up period. Conclusions. Very narrow aortic bifurcations may predispose patients to procedure-related complications following EVAR. Our results suggest a safe use of the AFX stent graft in such scenarios. The overall short- and long-term procedure-related patient outcomes are satisfying albeit they may seem superior for PAU when compared to AAA.
An English Mobile Learning Platform Embedded in GSM-R Wireless Network Communication
Authors: Zhen Ling
Published: October 2021

English mobile learning platform is affected by external interference signals, resulting in poor remote transmission ability of English information. To solve this problem, a design of the English mobile learning platform based on the GSM-R wireless network communication system is proposed. The overall framework of the English mobile learning platform is designed. MSP430F149 single-chip microcomputer is selected as the hardware microcontrol unit of the platform, and R-C reset circuit is designed. The reset circuit is used to reset the single-chip microcomputer platform to prevent external signal interference. The modem is initialized according to AT instruction, and the main program flow of the single-chip microcomputer of the English mobile learning platform is designed on this basis. GSM-R wireless network communication system is used to plan the course module. After planning, the platform operation management function is designed, the interactive learning environment is established, the user information template is designed, and the platform database is built. The experimental results show that the designed English mobile learning platform can meet the learning needs and improve students’ comprehensive ability after application.
Development and Application of the 3D Model Test System for Water and Mud Inrush of Water-Rich Fault Fracture Zone in Deep Tunnels
Authors: Guo Yanhui , Kong Zhijun , He Jin , Yan Ming
Published: October 2021

In order to study the evolution process, damage characteristics, and occurrence mechanism of water and mud inrush disaster in deep tunnel fault zone with infiltration instability under complex conditions, a set of the three-dimensional physical model test systems of water and mud inrush flow-solid coupling in tunnel fault zones is developed. The system mainly comprises a rigid test frame, ground stress loading system, hydraulic loading system, multiple information monitoring and acquisition system, and mud and water protrusion recovery system. The system’s main features are that it can meet the model’s simulation of the ground stress field, water pressure, and other complex environments subjected to ground stress, and water pressure gradients can be controlled. The system is characterized by high rigidity, high-pressure strength, visualization, good sealing, and expandability. Taking the water fault zone of a well in the Dazhu Mountain Tunnel of the Darui Railway as the research object, the new fault zone and surrounding rock similar materials applicable to the flow-solid coupling model test are designed using the self-developed flow-solid coupling similar materials. The system is used for model tests to reveal the spatial and temporal changes of the surrounding rock stress field and seepage field during the tunnel excavation process. The test results show that the system is stable and reliable, and the research method and results are of guiding significance to the research of the same type of underground engineering.
Key Technologies of Collaborative Design and Manufacturing of Mechanical and Electrical Products Based on Internet of Things
Authors: Shang Kun
Published: October 2021

An electric motor driven by the electromechanical system of the Internet of Things is attractive because of its long life capability of the propulsion system. In this paper, the application of collaborative design and manufacturing in the design automation of IOT electromechanical system is reviewed, and the application of collaborative design and manufacturing in robots, a typical IOT electromechanical system, is described in detail. In this paper, we explain five aspects including the construction of a multiangle unified modeling method for the electromechanical system of the Internet of Things; the constraint processing mechanism for the optimization problem of the electromechanical system of the Internet of Things; the constraint multiobjective optimization methods; design methods that integrate constraint multipurpose evolutionary algorithms and knowledge extraction; and design automation of visual perception systems for electromechanical systems based on the Internet of Things and deep neural networks. The research shows that under the control of a conventional radial basis function neural network controller and the control of a radial basis function neural network controller based on the electromechanical system of the Internet of Things, the system will be affected to a certain extent when there is interference. Under the control of a traditional RBF neural network controller, the system requires 0.18 seconds to restore stability. When using the RBF neural network controller based on the electromechanical system of the Internet of Things, the system returns to a stable state after 0.09 s, and the peak time is reduced by 59% compared with the conventional RBF neural network controller.
A Fault Diagnosis Method for Out‐of‐Round Faults of Metro Vehicle Wheels with Strong Noise
Authors: Huang Haifeng , Wang Heli , Zhang Weijiu , Gu Weijie
Published: October 2021

Detection of out‐of round (OOR) faults of metro vehicle wheels is very important to improve stationarity and stability in metro vehicles and avoid accidents caused by OOR faults. Diagnosis of OOR faults demands extracting useful information accurately from mass of vibration signals with poor signal‐to‐noise ratio (SNR) of metro vehicle wheels for complex running condition. In this paper, we proposed a diagnosis method on OOR faults of metro vehicle wheels combined with variational mode decomposition (VMD), kernel principal component analysis (KPCA), and deep belief network (DBN) to diagnose the OOR faults of metro wheels. Vibration signals of China metro vehicle wheels collected while the metro vehicle is running are used to train the diagnosis model and adjust parameters of DBN and KPCA based on testing accuracy. The different dimensions of KPCA, epoch number, and node number of DBN are compared, and the better parameters of diagnosis model based on vibration signals are concluded in this paper. The generalization of the diagnosis model is checked nine times by testing the calculation of each group of parameters and using an error declining process. The mean accuracy of diagnosis model proposed in this paper is 0.9136, and the diagnosis model presented in this paper is very significant to detect OOR faults online.
Environmental Impacts on Male Reproductive Development: Lessons from Experimental Models
Authors: Jorgensen Anne , Svingen Terje , Miles Harriet , Chetty Tarini , Stukenborg Jan-Bernd , Mitchell Rod T.
Published: October 2021

Background: Male reproductive development in mammals can be divided into a gonadal formation phase followed by a hormone-driven differentiation phase. Failure of these processes may result in Differences in Sex Development (DSD), which may include abnormalities of the male reproductive tract, including cryptorchidism, hypospadias, infertility, and testicular germ cell cancer (TGCC). These disorders are also considered to be part of a testicular dysgenesis syndrome (TDS) in males. Whilst DSDs are considered to result primarily from genetic abnormalities, the development of TDS disorders is frequently associated with environmental factors. Summary: In this review, we will discuss the development of the male reproductive system in relation to DSD and TDS. We will also describe the experimental systems, including studies involving animals and human tissues or cells that can be used to investigate the role of environmental factors in inducing male reproductive disorders. We will discuss recent studies investigating the impact of environmental chemicals (e.g., phthalates and bisphenols), lifestyle factors (e.g., smoking) and pharmaceuticals (e.g., analgesics) on foetal testis development. Finally, we will describe the evidence, involving experimental and epidemiologic approaches, for a role of environmental factors in the development of specific male reproductive disorders, including cryptorchidism, hypospadias, and TGCC. Key Messages: Environmental exposures can impact the development and function of the male reproductive system in humans. Epidemiology studies and experimental approaches using human tissues are important to translate findings from animal studies and account for species differences in response to environmental exposures.
A morte em fotografias periciais
Authors: Braud Paula Pagliari de
Published: October 2021

Este artigo tem por objetivo refletir sobre as fotografias periciais necroscópicas realizadas em casos de letalidade policial ocorridos na cidade de São Paulo e, por meio da bibliografia atinente à antropologia da imagem e da fotografia, aproximar e afastar análises de alguns autores que também trabalham a relação entre imagem e morte. Por meio da análise de cinco imagens retiradas de laudos necroscópicos de processos judiciais e inquéritos digitalizados no Tribunal de Justiça do Estado de São Paulo, busca-se entender como os usos e os contextos de produção dessas fotografias nos permitem compreender a maneira como expressamos e encaramos certas mortes.
Musicando translocalidades imigrantes aymaras e quechuas em São Paulo
Authors: Branco Cristina de , Teófilo Mariana Santos
Published: October 2021

Caminhando por algumas ruas e praças da cidade de São Paulo, nos domingos de todo o ano e em dias de festa comunitária boliviana, vamos percorrendo localidades altiplânicas (Appadurai 1996) erguidas a três mil quilômetros de distância do Altiplano andino. Milhares de transmigrantes andinos bolivianos reelaboram suas dinâmicas culturais e afetivas através da criação de redes transnacionais (Glick Schiller, Basch e Szanton 1992), comerciais e simbólicas. Também através do musicar autóctone (Small 1998), especialmente da prática musical de repertório e tocadores aymaras e quechuas, se fortalecem as estruturas afetivas que constituem e afirmam performática e sinestesicamente localidades altiplânicas indígenas. Por meio da articulação teórico-etnográfica de base antropológica e etnomusicológica, buscamos refletir sobre como o Centro Cultural Kollasuyo Maya, grupo autóctone de formação aymara e quechua, ao ativar e integrar redes entre pessoas e coletivos indígenas, imigrantes e paulistanos, vai musicalizando e localizando o Altiplano andino boliviano em São Paulo.
Retratando o musicar do bumba meu boi no audiovisual
Authors: Coelho Luiza Fernandes
Published: October 2021

Este artigo apresenta reflexões sobre como a prática do musicar (Small 1998) e o caráter participativo (Turino 2008) do bumba meu boi são traduzidos na linguagem audiovisual (Romero e Villela 2018) nas produções Guriatã – direção de Renata Amaral (2018) –, Taquaras, Tambores e Violas – direção de Hidalgo Romero (2018) – e Brilho da Noite , direção de Priscila Ermel (2004). O artigo expõe quais musicares dessa manifestação cada produção enfatiza e quais as técnicas utilizadas para traduzi-los para a linguagem audiovisual, realizando também um comparativo entre as técnicas de cada produção. Esses filmes foram escolhidos, pois seus realizadores são de diferentes campos de trabalho e pesquisa, possuindo estéticas e finalidades diversas.
Um ouvido no fone e o outro na cidade: por uma representação audiovisual do musicar local
Authors: Bertho Renan Moretti , Nakaóka Elias Alexsânder , Demarchi Brenno Brandalise , Hartmann Anna Flávia Guimarães , Barbosa Arthur Silva , Pereira Luiz Henrique Campos , Ventura Noelle Rodrigues
Published: October 2021

O presente artigo discute a utilização do audiovisual para representar as características e as possibilidades de um musicar local. Ao observar o processo de criação do documentário Um ouvido no fone e o outro na cidade, os(as) autores(as) refletem sobre os usos e as funções da música, bem como sobre o engajamento musical e a relação de escuta dos(as) riders – entregadores(as) de comida por aplicativo. Esses(as) profissionais são brasileiras e brasileiros que moram em Dublin e que têm a música como parte essencial da sua rotina de trabalho. Nesse sentido, nossa questão é: como representar as diversidades e as contradições desse musicar local? Argumentamos que, por meio das etapas coletivas de desenvolvimento e criação desse documentário, os(as) realizadores(as) expressam não apenas o engajamento dos(as) riders com a música, mas também constroem uma representação sensorial do musicar que perpassa as relações de trabalho, de afeto e de localidade.
A Teoria Ator-Rede como ferramenta para releitura do social a partir do filme Her
Authors: Brindarolli Ana Carolina
Published: October 2021

A tecnologia normalmente é vista como impessoal e sem vida, e perde essa característica na obra cinematográfica Her. A obra nos direciona para linhas de raciocínios inusitadas. O presente ensaio usa como pretexto o filme Her para propor um olhar sobre as novas formas de se relacionar na contemporaneidade, formas que unem atores humanos e não humanos para a produção de um coletivo, no sentido latouriano, para além da sociedade. Este coletivo tem como produto social o ator/actante híbrido, na proposta de visualizar a união no mesmo contexto de humanos e tecnologias. Desse modo, proponho a utilização da obra cinematográfica do diretor Spike Jonze, como um campo audiovisual capaz de produzir no leitor uma imagem sobre a temática latouriana proposta: novo social, atores híbridos, mediação, coletivos, interação entre humano e não humano. Como fundamentação teórica, o ensaio transita por conceitos extraídos da Teoria Ator-Rede (TAR).
Musicar local: tema e variações
Authors: Giesbrecht Érica , G. Hikiji Rose Satiko , Grunvald Vitor
Published: October 2021

A noção de musicar local vem sendo experimentada em um projeto temático do qual as três organizadoras deste dossiê participam. Desde 2016, temos orientado nossas pesquisas em torno desta expressão que une o conceito de musicar – traduzido de musicking de Christopher Small – com a noção de localidade, pensada a partir das considerações de autores como Arjun Appadurai e Ruth Finnegan. Musicar, na acepção de Small (1998), é utilizado para se referir a qualquer forma de engajamento com a música, entendida não apenas em seus aspectos formais (a obra musical), mas igualmente como performance, fruição, consumo, transmissão musical etc.
PCSK9 Activity Is Potentiated Through HDL Binding
Authors: Burnap Sean A. , Sattler Katherine , Pechlaner Raimund , Duregotti Elisa , Lu Ruifang , Theofilatos Konstantinos , Takov Kaloyan , Heusch Gerd , Tsimikas Sotirios , Fernández-Hernando Carlos , Berry Sarah E. , Hall Wendy L. , Notdurfter Marlene , Rungger Gregorio , Paulweber Bernhard , Willeit Johann , Kiechl Stefan , Levkau Bodo , Mayr Manuel
Published: October 2021

Rationale:

PCSK9 (proprotein convertase subtilisin/kexin type 9) circulates in a free and lipoprotein-bound form, yet the functional consequence of the association between PCSK9 and HDL (high-density lipoprotein) remains unexplored.

Objective:

This study sought to interrogate the novel relationship between PCSK9 and HDL in humans.

Methods and Results:

Comparing lipoprotein and apolipoprotein profiles by nuclear magnetic resonance spectroscopy and targeted mass spectrometry measurements with PCSK9 levels in the community-based Bruneck study (n=656) revealed a positive association of plasma PCSK9 with small HDL, alongside a highly significant positive correlation between plasma levels of PCSK9 and apolipoprotein C3 (apoC3), an inhibitor of lipoprotein lipase. The latter association was replicated in an independent cohort, the SAPHIR study (Salzburg Atherosclerosis Prevention Program in Subjects at High Individual Risk; n=270). Thus, PCSK9-HDL association was determined during the postprandial response in two dietary studies (n=20 participants each, 8 time points). Peak triglyceride levels coincided with an attenuation of the PCSK9-HDL association, a loss of apoC3 from HDL, and lower levels of small HDL as measured by nuclear magnetic resonance spectroscopy. Crosslinking mass spectrometry upon isolated HDL identified PCSK9 as a potential HDL-binding partner. PCSK9 association with HDL was confirmed through size-exclusion chromatography and immuno-isolation. Quantitative proteomics upon HDL isolated from patients with coronary artery disease (n=172) returned PCSK9 as a core member of the HDL proteome. Combined interrogation of the HDL proteome and lipidome revealed a distinct cluster of PCSK9, phospholipid transfer protein, clusterin, and apolipoprotein E within the HDL proteome that was altered by sex and positively correlated with sphingomyelin content. Mechanistically, HDL facilitated PCSK9-mediated low-density lipoprotein receptor degradation and reduced low-density lipoprotein uptake through the modulation of PCSK9 internalization and multimerization.

Conclusions:

This study reports HDL as a binder of PCSK9 and regulator of its function. The combination of -omic technologies revealed postprandial lipemia as a driver of PCSK9 and apoC3 release from HDL.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT03191513; URL:
https://www.isrctn.com
; Unique identifier: ISRCTN20774126.
Impact of Model Choice When Studying the Relationship Between Blood Pressure Variability and Risk of Stroke Recurrence
Authors: de Courson Hugues , Ferrer Loïc , Barbieri Antoine , Tully Phillip J. , Woodward Mark , Chalmers John , Tzourio Christophe , Leffondré Karen
Published: October 2021

Long-term blood pressure variability (BPV), an increasingly recognized vascular risk factor, is challenging to analyze. The objective was to assess the impact of BPV modeling on its estimated effect on the risk of stroke. We used data from a secondary stroke prevention trial, PROGRESS (Perindopril Protection Against Stroke Study), which included 6105 subjects. The median number of blood pressure (BP) measurements was 12 per patient and 727 patients experienced a first stroke recurrence over a mean follow-up of 4.3 years. Hazard ratios (HRs) of BPV were estimated from 6 proportional hazards models using different BPV modeling for comparison purposes. The 3 commonly used methods first derived SD of BP measures observed over a given period of follow-up and then used it as a fixed covariate in a Cox model. The 3 more advanced modeling accounted for changes in BP or BPV over time in a single-stage analysis. While the 3 commonly used methods produced contradictory results (for a 5 mmHg increase in BPV, HR=0.75 [95% CI, 0.68–0.82], HR=0.99 [0.91–1.08], HR=1.19 [1.10–1.30]), the 3 more advanced modeling resulted in a similar moderate positive association (HR=1.08 [95% CI, 0.99–1.17]), whether adjusted for BP at randomization or mean BP over the follow-up. The method used to assess BPV strongly affects its estimated effect on the risk of stroke, and should be chosen with caution. Further methodological developments are needed to account for the dynamics of both BP and BPV over time, to clarify the specific role of BPV.