bluuebunny/crossref_metadata_2025 huggingface dataset:
Simulation of Thermomechanical Coupling and Evaluation of the Fire Resistance for the Joints of Fabricated Frame Tunnel
Authors: Huang Zhen , Zhang Jiawei , Peng Zimao , Hu Hongbo , An Huiping , Yang Xulong , Xiong Tianxiang
Published: December 2022

Fire in a tunnel will deteriorate the mechanical properties of the tunnel. For fabricated tunnels formed by splicing prefabricated components through joints, under the high temperature of a fire, the rapid degradation of the bearing capacity of the joints can easily lead to tunnel damage. In this study, a new type of joint (bolt-pin joints (BPJ)) for prefabricated frame tunnels is proposed. To investigate the fire resistance of the new joint and the other three fabricated frame tunnel joints (including mortise joints (MJ), bolt-mortise joints (BMJ), and pin joints (PJ)), a three-dimensional solid model of four types of fabricated frame tunnel joints is established using the finite element calculation software ABAQUS. According to the standard European HC curve, the heat transfer characteristics of the joint model are analyzed, the temperature distribution law of the joint under fire is studied, and the flexural bearing performance and deformation characteristics of the joint before and after the fire are discussed, as well as the influence of the initial axial force on the flexural bearing capacity and the opening of the joint under fire. The analysis result shows that the vertical peak load of the BPJ is higher than that of the other three joints at room temperature. Under the combined action of the pin and bolts and the tongue groove, the vertical peak load of the joints can be effectively increased and the midspan vertical displacement can be reduced. The decrease degree of the vertical peak load of the MJ and BMJ under fire exposure is greater than that of the other two joints, and the opening of the BPJ is 19 mm, which is much smaller than that of the other three joints. When the initial axial force is increased, the openings of the four joints under fire exposure are reduced, the vertical peak loads of the PJ and BPJ are increased, and the vertical peak loads of the MJ and BMJ are not significantly increased. Overall, the BPJ demonstrates better fire resistance.
Post Mortem Image Analysis of Astrocytes of the Human Principal Olivary Nucleus Using Geometrical and Fractal Parameters
Authors: Stojić Damjan , Radošević Dragana
Published: December 2022

Based on their morphology, the most abundant cells within the nervous tissue of the central nervous system, astrocytes, can be divided into two types, protoplasmic astrocytes and fibrous astrocytes. A further analysis of the brain tissue with the preserved astrocytes from the human principal olivary nucleus, based on their morphological differences with age, is successfully performed in this paper. Moreover, the images of 294 astrocytes, 148 fibrous and 146 protoplasmic, from the principal olivary nucleus were used. Applied for the first time in astrocytes image analysis, the principal component analysis was used to find the most informative parameters among geometrical and fractal in each of the four predefined groups, i.e., categories, of the morphological measurements of astrocytes in the images. The proposed subsets representing different morphological features can be used to distinguish astrocyte subtypes and predict their changes during normal aging. The values of the adequated parameters in different subsets were compared between the fibrous and protoplasmic astrocytes and correlated with age. Significant differences (p < 0.05) between the two subtypes were found in four Euclidean and four monofractal parameters. In addition, significant correlations were found between selected parameters and the age of subjects. In the upcoming iterations of this procedure, possible refinement and upgrades are expected.
Comparison of Marker Effects and Breeding Values at Two Levels at THI for Milk Yield and Quality Traits in Brazilian Holstein Cows
Authors: Carrara Eula Regina , Dauria Brayan Dias , Gervásio Izally Carvalho , Silveira Robson Mateus Freitas , Rovadoski Gregori Alberto , Petrini Juliana , Salvian Mayara , Machado Paulo Fernando , Mourão Gerson Barreto
Published: December 2022

Genomic tools can help in the selection of animals genetically resistant to heat stress, especially the genome-wide association studies (GWAS). The objective of this study was to compare the variance explained by SNPs and direct genomic breeding values (DGVs) at two levels of a temperature and humidity index (THI). Records of milk yield (MY), somatic cell score (SCS), and percentages of casein (CAS), saturated fatty acids (SFA), and unsaturated fatty acids (UFA) in milk from 1157 Holstein cows were used. Traditional breeding values (EBV) were determined in a previous study and used as pseudo-phenotypes. Two levels of THI (heat comfort zone and heat stress zone) were used as environments and were treated as “traits” in a bi-trait model. The GWAS was performed using the genomic best linear unbiased prediction (GBLUP) method. Considering the top 50 SNPs, a total of 36 SNPs were not common between environments, eight of which were located in gene regions related to the evaluated traits. Even for those SNPs that had differences in their explained variances between the two environments, the differences were very small. The animals showed virtually no rank order, with rank correlation values of 0.90, 0.88, 1.00, 0.88, and 0.97 for MY, CAS, SCS, SFA, and UFA, respectively. The small difference between the environments studied can be attributed to the small difference in the pseudo-phenotypes used between the environments, on-farm acclimation, the polygenic nature of the traits, and the THI values studied near the threshold between comfort and heat stress. It is recommended that future studies be conducted with a larger number of animals and at more extreme THI levels.
Online Health (Mis)Information: The Role of Medical Students
Authors: El Kheir Dalia Y. M. , Al Awani Zainab T. , Alrumaih Zainb A. , Assad Majd A.
Published: December 2022

The public perceive social media as a convenient source of health information. Some physicians might use this to enhance their visibility and market value. In this study, we aimed to assess medical students’ awareness of regulations for dispersion of health-related information on social media and physicians’ online self-promotional activities. A cross-sectional study was conducted among undergraduate medical students from the 3 largest administrative regions of Saudi Arabia: Central, Western, and Eastern regions. Data was collected between February–July 2020 via online distribution of a self-administered questionnaire. Results showed that: (a) a total of 730 medical students participated; (b) about half of respondents were unsure or unaware of guidelines of both, online posting of medical information and physicians’ online self-promotional activities (343/47% and 385/52.7%, respectively); (c) 610 (83.6%) students supported that healthcare providers report accounts sharing unreliable health information. Physicians’ online promotional activities, and posting about successful cases, might shift physicians’ focus from patient care to becoming more popular online. Care should be taken not to breach essential professional and ethical principles, such as protecting the confidentiality and privacy of patients. Raising awareness among patients and physicians, current and future ones, of the regulations governing these online health related interactions is imperative.
Metabolomic and Transcriptomic Analyses Reveal New Insights into the Role of Metabolites and Genes in Modulating Flower Colour of Clematis tientaiensis
Authors: Qian Renjuan , Ye Youju , Hu Qingdi , Ma Xiaohua , Zhang Xule , Zheng Jian
Published: December 2022

Clematis tientaiensis is an ornamental plant with beautiful flowers that belongs to the Ranunculaceae family. C. tientaiensis is endemic to Zhejiang Province in China. Five different colours of the C. tientaiensis flower have been observed, and to explore the reason for this flower colour variation, transcriptome and metabolome sequencing analyses were conducted in this study. The results indicate that 32 metabolites participate in anthocyanin biosynthesis, and that 24 metabolites were differentially accumulated among the five different flower colours. The transcriptome sequencing results enabled the identification of 13,559 differentially expressed genes. Further analysis indicated that cyanidin-3-O-galactosidea and cyanidin-3-O-sophoroside promote anthocyanin accumulation in the flowers of C. tientaiensis, whereas the pelargonidin-3-O-galactoside plays a negative role in anthocyanin synthesis. In addition, a combined transcriptome and metabolome analysis showed that the WDR2 gene plays an important regulatory role in anthocyanin biosynthesis. The results of this study provide a basis for further research into the biosynthesis and regulation of anthocyanins in C. tientaiensis flowers.
Exploring Managerial Job Demands and Resources in Transition to Distance Management: A Qualitative Danish Case Study
Authors: Andersone Nelda , Nardelli Giulia , Ipsen Christine , Edwards Kasper
Published: December 2022

Organizations worldwide have shifted to working from home, requiring managers to engage in distance management using information and communication technologies (ICT). Studies show that managers experience high job demands and inadequate guidance during COVID-19; therefore, the transition to distance management raises questions about the increase in managerial job demands and the impact on managers’ well-being. This study aims to explore first-line managers’ perceptions of job demands and available resources during the first year of the pandemic and understand the implications for first-line managers’ well-being. First-line managers face complex and conflicting demands, making them more challenged in their management task than other management levels. We used the job demands–resources model in this qualitative, longitudinal empirical study. The study draws on 49 semi-structured interviews with seven first-line managers from a large pharmaceutical company in Denmark, whom we followed throughout the first year of the COVID-19 pandemic, from May 2020 to May 2021. Our findings suggest that the first-line managers perceived increased emotional and practical demands. While the managers appreciated the initial guidance provided by the organization, they perceived the organizational support as outdated and superficial. As a result, to cope with the uncertainty caused by the pandemic and the shift to distance management, the managers relied on work engagement enablers such as social support. Even though the COVID-19 pandemic portrays unique circumstances in transitioning to distance management that require further exploration outside the COVID-19 context, the insights from this study can assist organizations in developing awareness about transitions to better support first-line management to embrace changes in the future.
Comparison of Metabolic Characteristics of Physically Active Individuals with Different Training Habits during Incremental Treadmill Test
Authors: Nagy Dóra , Trunic Nenad , Prémusz Viktória , Krutek László , Lipcsik Zoltán , Ács Pongrác
Published: December 2022

The number of people engaging in self-conducted regular physical activity is increasing, but the effects of home fitness and individually planned workouts on health and metabolism are unknown. We aimed to examine the effects of regular training conducted without the supervision of professionals on exercise metabolism in our cross-sectional observational study. Forty-five physically active volunteers, classified into three groups, based on the type and frequency of their training (group 1 frequent long-term endurance, group 2 three times per week aerobic training, and group 3 two times per week short aerobic and resistance training), fulfilled a vita maxima incremental treadmill test. Aerobic capacity (VO2max), MET (metabolic equivalent of task), and metabolic responses were examined. The results were evaluated by ANOVA and Bonferroni and Scheffe multiple comparison analysis using Microsoft Excel and SPSS 23 programs. (p < 0.05). Significant differences were found between group 1 and 3 in VO2max (p = 0.46) and MET (p = 0.46) between group 1 and 2, in FatmaxHR (heart rate on maximum fat oxidation) (p= 0.04). We concluded self-conducted regular physical activity has positive effects on metabolism and health. Aerobic training performed four times per week showed the most beneficial effects on metabolism and health maintenance. In addition, based on our findings, strength training performed two times per week is recommended.
Interventions Designed to Support Physical Activity and Disease Prevention for Working from Home: A Scoping Review
Authors: Crane Melanie , Cobbold Alec , Beck Matthew , Nau Tracy , Standen Christopher , Rissel Chris , Smith Ben J. , Greaves Stephen , Bellew William , Bauman Adrian
Published: December 2022

Working from home (WfH) has public health implications including changes to physical activity (PA) and sedentary behavior (SB). We reviewed published and grey literature for interventions designed to support PA or reduce SB in WfH contexts. From 1355 published and grey literature documents since 2010, we screened 136 eligible documents and extracted ten intervention studies. Interventions designed specifically for WfH were limited and included structured exercise programs, infrastructure (e.g., sit-stand workstations), online behavioral and educational programs, health professional advice and peer support, activity trackers and reminder prompts. Evidence of interventions to improve PA and reduce SB in WfH contexts is emergent but lacking in variety and in utilization of local environments to promote good health. Evidence is needed on the adaptation of existing workplace interventions for home environments and exploration of opportunities to support PA through alternative interventions, such as urban planning and recreational strategies.
Examining the Effectiveness of the Discharge Plan Model on the South Korean Patients with Cancer Completed Cancer Treatment and Are Returning to the Community: A Pilot Study
Authors: Kim Young Ae , Choi Hye Ri , Choi Mingee , Park Ah Kyung , Kim Hye Ryun , Lee Chaemin , Lee Elim , Kim Kyung Ok , Kwak Mi Young , Chang Yoon Jung , Jung So-Youn
Published: December 2022

This study aimed to examine the effectiveness of a discharge plan model for South Korean patients with cancer who had completed treatment and were returning to the community. Overall, 23 patients with cancer were recruited at the National Cancer Center in Goyang-si. The effectiveness of the discharge plan was examined using four methods: Social Needs Screening Toolkit (2018), early screening for discharge plan, current life situation v.2.0, and a questionnaire regarding problems after discharge from the hospital. Subsequently, the results were analyzed using descriptive statistical analysis methods with the Stata 14.0 program. The largest age group of study participants was between 45 and 64 years. No participants responded to urgent needs, whereas nine (39.13%) participants needed support for their social needs. According to the in-depth evaluation of participants, more than 80% of the respondents answered that patients with cancer needed no help in self-management, daily living activities, or mental health. The satisfaction survey results showed that the degree to which the “discharge plan” was helpful for health management at home after discharge was 4.41 of 5, and the degree to which it helped return to daily life was 3.86 of 5.
Peristomal Skin Complications in Ileostomy and Colostomy Patients: What We Need to Know from a Public Health Perspective
Authors: D’Ambrosio Floriana , Pappalardo Ciro , Scardigno Anna , Maida Ada , Ricciardi Roberto , Calabrò Giovanna Elisa
Published: December 2022

Background: Peristomal skin complications (PSCs) are the most common skin problems seen after ostomy surgery. They have a considerable impact on a patient’s quality of life and contribute to a higher cost of care. Methods. A systematic review was conducted, querying three databases. The analysis was performed on international studies focused on the clinical-epidemiological burden of PSCs in adult patients with ileostomy/colostomy. Results: Overall, 23 studies were considered. The main diseases associated with ostomy surgery were rectal, colon and gynecological cancers, inflammatory bowel diseases, diverticulitis, bowel obstruction and intestinal perforation. Erythema, papules, skin erosions, ulcers and vesicles were the most common PSCs for patients with an ostomy (or stoma). A PSCs incidence ranging from 36.3% to 73.4% was described. Skin complications increased length of stay (LOS) and rates of readmission within 120 days of surgery. Conclusions: PSCs data are still limited. A knowledge of their burden is essential to support health personnel and decision-makers in identifying the most appropriate responses to patients’ needs. Proper management of these complications plays a fundamental role in improving the patient’s quality of life. A multidisciplinary approach, as well as increased patient education and their empowerment, are priority measures to be implemented to foster a value-based healthcare.
Antiandrogenic and Estrogenic Activity Evaluation of Oxygenated and Nitrated Polycyclic Aromatic Hydrocarbons Using Chemically Activated Luciferase Expression Assays
Authors: Misaki Kentaro , Tue Nguyen Minh , Takamura-Enya Takeji , Takigami Hidetaka , Suzuki Go , Tuyen Le Huu , Takahashi Shin , Tanabe Shinsuke
Published: December 2022

To establish the risk of the endocrine disrupting activity of polycyclic aromatic compounds, especially oxygenated and nitrated polycyclic aromatic hydrocarbons (oxy-PAHs and nitro-PAHs, respectively), antiandrogenic and estrogenic activities were determined using chemically activated luciferase expression (CALUX) assays with human osteoblast sarcoma cells. A total of 27 compounds including 9 oxy-PAHs (polycyclic aromatic ketones and quinones) and 8 nitro-PAHs was studied. The oxy-PAHs of 7H-benz[de]anthracen-7-one (BAO), 11H-benzo[a]fluoren-11-one (B[a]FO), 11H-benzo[b]fluoren-11-one (B[b]FO), and phenanthrenequinone (PhQ) exhibited significantly the potent inhibition of AR activation. All nitro-PAHs exhibited high antiandrogenic activities (especially high for 3-nitrofluoranthene (3-NFA) and 3-nitro-7H-benz[de]anthracen-7-one (3-NBAO)), and the AR inhibition was confirmed as noncompetitive for 3-NFA, 3-NBAO, and 1,3-dinitropyrene (1,3-DNPy). Antiandrogenic activity of 3-NFA demonstrated characteristically a U-shaped dose–response curve; however, the absence of fluorescence effect on the activity was confirmed. The prominent estrogenic activity dependent on dose–response curve was confirmed for 2 oxy-PAHs (i.e., B[a]FO and B[b]FO). Elucidating the role of AR and ER on the effects of polycyclic aromatic compounds (e.g., oxy- and nitro-PAHs) to endocrine dysfunctions in mammals and aquatic organisms remains a challenge.
Tourist Landscape Preferences in a Historic Block Based on Spatiotemporal Big Data—A Case Study of Fuzhou, China
Authors: Liu Fan , Sun Danmei , Zhang Yanqin , Hong Shaoping , Wang Minhua , Dong Jianwen , Yan Chen , Yang Qin
Published: December 2022

Historic blocks are valuable architectural and landscape heritage, and it is important to explore the distribution characteristics of tourists to historic blocks and their landscape preferences to realize the scientific construction and conservation of historic blocks and promote their sustainable development. At present, few studies combine the analysis of tourist distribution characteristics with landscape preferences. This study takes the historic block of Three Lanes and Seven Alleys in Fuzhou as an example, combines field research and questionnaires to construct a landscape preference evaluation indicator system for the historic block, measures the distribution characteristics of tourists in the block through the heat value of tourist flow obtained from the Tencent regional heat map, and analyses the influence of landscape preference indicators on the heat value of tourist flow in the block through stepwise multiple linear regression. The research shows that: (1) the spatial and temporal variation in the heat value of tourist flow tends to be consistent throughout the block, from 7 a.m. to 6 p.m., showing a “rising, slightly fluctuating and then stabilizing” state, both on weekdays and on weekends. (2) The factors influencing the heat value of tourist flow in the different spatial samples are various, with commercial atmosphere, plant landscape, accessibility of the road space, architecture, and the surrounding environment having a significant impact on the heat value of tourist flow. Based on the analysis of the landscape preferences of tourists in the historic block, a landscape optimization strategy is proposed to provide a reference for the management and construction of the block.
A Time Series Study for Effects of PM10 on Coronary Heart Disease in Ganzhou, China
Authors: Liu Tingting , Huang Hui , Hu Gonghua
Published: December 2022

Objective: To investigate the effect of PM10 exposure in low concentration areas on the daily hospitalized patients with coronary heart disease. Methods: Daily air quality monitoring data, meteorological monitoring data and daily hospitalization data of coronary heart disease during 2019–2021 in Ganzhou, China were collected. Generalized additive model and distributed lag nonlinear model were used to evaluate the association between environmental PM10 and daily hospital visits for coronary heart disease. Stratified by sex and age to see their potential impact on this association. Results: PM10 exposure was correlated with an increased risk of hospitalization in coronary heart disease patients. Single-pollutant model analysis shows that at the day of lag1, for every 10 µg/m3 increase in PM10, the risk of coronary heart disease hospitalization increased by 1.69% (95%CI 0.39~3.00%); Subgroup analysis showed that females and older adults (>65 years) were more sensitive to PM10 exposure. In addition, in the dual-pollutant model, by adjusting other pollutants (including SO2, CO and O3), it was found that the relationship between PM10 exposure and coronary heart disease hospitalization was robust. And with changing the model’s degree of freedom was still robust. Conclusion: Short-term exposure to low concentrations of PM10 is associated with hospitalization for coronary heart disease. These results are important for local environmental public health policy development, so as to protect vulnerable populations.
Lower Extremity Muscle Performance and Foot Pressure in Patients Who Have Plantar Fasciitis with and without Flat Foot Posture
Authors: Lee Jin Hyuck , Shin Ki Hun , Jung Taek Sung , Jang Woo Young
Published: December 2022

Abnormal foot posture and poor muscle performance are potential causes of plantar fasciitis (PF). However, no study has compared the differences between lower extremity muscle performance and foot pressure in patients who have PF with and without abnormal foot postures. This study aimed to compare the differences in lower extremity muscle performance, such as in the hip, quadriceps, hamstring, and plantar flexor, and foot pressure in patients who have PF with and without flat foot postures. Seventy patients with plantar heel pain were enrolled (37 flat feet and 33 without flat feet). The hip muscle strength was measured using a handheld digital dynamometer. The strength and reaction time of the quadriceps, hamstring, and plantar flexor muscles were evaluated using an isokinetic device. Foot pressure parameters were assessed using pedobarography. The strength of the plantar flexor muscles was significantly lower (p = 0.008), while the reaction time of the plantar flexor muscles was significantly faster (p = 0.007) for the involved feet of PF patients with flat feet than in those without flat feet. This study confirmed the differences in muscle performance between patients who have PF with different foot postures. Therefore, clinicians and therapists should plan treatment considering the differences in these characteristics for the management of these patients.
Disability among Women and Men Who Married in Childhood: Evidence from Cross-Sectional Nationally Representative Surveys Undertaken in 37 Low- and Middle-Income Countries
Authors: Emerson Eric , Llewellyn Gwynnyth
Published: December 2022

Child marriage, which the UN’s Sustainable Development Goal seeks to eliminate by 2030, represents a violation of the human rights of children. These concerns are driven by the negative impact of child marriage on the health of children married in childhood and their children. Little is known about the association between child marriage and disability. We sought to estimate the strength of association between disability and child marriage among women and men in middle- and low-income countries (LMICs). Secondary analysis was undertaken of nationally representative samples involving 423,164 women in 37 LMICs and 95,411 men in 28 LMICs. Results were aggregated by random effects meta-analysis and mixed effects multilevel multivariate modelling. The prevalence of disability was significantly greater among women and men who were married in childhood, especially among those married under the age of 16. The strength of these associations varied by age group and age at first marriage. Further research is required to understand the causal pathways responsible for the increased likelihood of disability among women and men married in childhood. National initiatives to eliminate child marriage may need to consider making reasonable accommodations to policies to ensure these are equally effective for women and men with disabilities.
Assessment of Stakeholder’s Perceptions of the Value of Coral Reef Ecosystem Services: The Case of Gili Matra Marine Tourism Park
Authors: Rahmadyani Ratu Fathia , Dargusch Paul , Adrianto Luky
Published: December 2022

Ecosystem services is a concept broadly applicable to describe environmental interrelations with human activities. It serves as a practical instrument for assessing the success of resource management in natural reserves, with the goals of maximising conservation effort and achieving sustainable use. The Gili Matra Marine Tourism Park (GMMTP) has been extensively researched as a marine protected area centred on anthropocentric activities of marine-based tourism. However, there still a lack of research to address the full scope of ecosystem services derived from the coral reef ecosystem. From an ecosystem services viewpoint, the study’s objectives were to define the services obtained from the GMMTP’s coral reef ecosystem, relevant stakeholders, and how their utilisation activities were posed as drivers of changes that reflect the flow of services and the possible implications of these. Marine tourism, capture fisheries, and land-based activities were identified as services impacting upon the regulating and supporting services, with the resultant compounding externalities potentially degrading the services’ utilisation value. Although there have been certain changes in community behaviour that may reduce the intensity of the impacts, the present prediction of service flow still confirms the previous statement. The results provided insight into current resources management implications on the state of ecosystem services. Overall, failing to recognise the causes that drives the interaction of these ecosystem services will increase the risk of incurring unexpected trade-offs, restricting the potential for resources’ synergies, and eventually causing drastic and irreversible changes in the provision of coral reef ecosystem services in the GMMTP.
The Effects of Adding Art Therapy to Ongoing Antidepressant Treatment in Moderate-to-Severe Major Depressive Disorder: A Randomized Controlled Study
Authors: Lee Myungjoo , Choi Han , Shin Jiwon , Suh Ho-Suk
Published: December 2022

This randomized controlled study aimed to investigate the effects of art psychotherapy on moderate-to-severe major depressive disorder (MDD). Forty-two MDD patients were recruited from a psychiatric outpatient clinic in Seoul, the Republic of Korea. Participants were allocated on a randomized, open-label basis to either an experimental group, wherein they were treated with art psychotherapy added to pharmacotherapy, or a control group, wherein they were treated with pharmacotherapy alone. Pre- and post-test measures of the Hamilton Depression Rating Scale, Beck Depression Inventory-II, and remission rates were measured. The results indicate that patients treated with art psychotherapy and ongoing pharmacotherapy showed slightly greater improvement when compared with pharmacotherapy alone in moderate-to-severe MDD. These results suggest that art psychotherapy could be an effective add-on strategy for the treatment of moderate-to-severe MDD. However, a rigorous test would facilitate a better understanding of art psychotherapy as an add-on strategy for MDD treatment.
From Social Networking Site Use to Subjective Well-Being: The Interpersonal and Intrapersonal Mediating Pathways of Prosocial Behavior among Vocational College Students in China
Authors: Hui Bryant Pui Hung , Au Algae Kit Yee , Ng Jacky Chi Kit , Song Xinmiao
Published: December 2022

In view of the growing importance of social networking sites (SNS) to adolescents and the mixed and inconclusive empirical evidence on the relationships between SNS use and their well-being, the present study aimed to investigate the associations of social function use intensity (SFUI) and entertainment function use intensity (EFUI) with adolescent life satisfaction and self-esteem, and examine the mediating roles that general prosocial behavior and school volunteering may play in the links. Drawing from the findings of a self-administered online survey with a valid sample of 3452 adolescents (mean age = 18.21) from 10 vocational colleges across four regions of China, our results demonstrated that there was an indirect positive effect of SFUI on adolescent life satisfaction and self-esteem via two interpersonal pathways of general prosocial behavior and school volunteering. We also discovered that there was an indirect negative effect of EFUI on adolescent life satisfaction and self-esteem via an intrapersonal pathway of school volunteering. Our findings provided empirical support for the differential effects of SFUI and EFUI on adolescent life satisfaction and self-esteem through the interpersonal and intrapersonal pathways, and unpacked the mediating roles of general prosocial behavior and school volunteering in these mechanisms.
Effect of Electrical Muscle Stimulation and Resistance Exercise Intervention on Physical and Brain Function in Middle-Aged and Older Women
Authors: Thapa Ngeemasara , Yang Ja-Gyeong , Bae Seongryu , Kim Gwon-Min , Park Hye-Jin , Park Hyuntae
Published: December 2022

This study investigated the effectiveness of electrical muscle stimulation (EMS) with resistance exercise training (ERT) and resistance exercise training (RT) on physical and brain function in middle-aged and older women. Method: Forty-eight participants were randomly allocated into three groups: (i) ERT (n = 16), (ii) RT (n = 16), and (iii) control group (n = 16). The intervention session was 50 min long and performed three times/week for four weeks. The ERT group performed quadriceps setting, straight leg raises, and ankle pump exercises while constantly receiving EMS on their quadriceps muscle on both legs. The RT group performed the same exercise without EMS. Physical function was measured using skeletal muscle mass index (SMI), handgrip strength, gait speed, five times sit-to-stand test (FTSS) and timed up-and-go test (TUG). Brain function was assessed with electroencephalogram measurement of whole brain activity. Results: After four-week intervention, significant improvements were observed in SMI (p < 0.01), phase angle (p < 0.05), and gait speed (p < 0.05) in the ERT group compared to the control group. ERT also increased muscle strength (p < 0.05) and mobility in lower limbs as observed in FTSS and TUG tests (p < 0.05) at post-intervention compared to the baseline. In the ERT group, significant positive changes were observed in Beta1 band power, Theta band power, and Alpha1 band whole brain connectivity (p < 0.005) compared to the control group. Conclusions: Our findings showed that ERT can improve muscle and brain function in middle-aged and older adults during a four-week intervention program whereas significant improvements were not observed with RT. Therefore might be one of the feasible alternative intervention to RT for the prevention of muscle loss whilst improving brain function for middle-aged and older population.
The Current Status of Breastfeeding Knowledge and Its Influencing Factors in Nursing Undergraduates: A Cross-Sectional Study in China
Authors: Liu Keqin , Guo Jinjin , Deng Weixi , Su Yanwei
Published: December 2022

The aim of this study was to explore the breastfeeding knowledge of nursing undergraduates and the influencing factors. Human milk (HM) is one of the most effective nutritional supplies to improve early development and physical health, but the current status of breastfeeding in China is still not optimal. The breastfeeding knowledge of perinatal women influences their feeding beliefs and behavior. Nursing undergraduates, as core professionals who will care for perinatal women and provide feeding guidance in the future, can significantly affect feeding behavior of mothers and their babies, so their knowledge of breastfeeding may have a potential impact on breastfeeding in China. However, studies on breastfeeding knowledge among nursing undergraduates in China are limited. A convenience sampling method was conducted in four medical universities in China, and eligible nursing undergraduates were selected. An online survey was collected from 5 July 2022 to 5 August 2022. Categorical data were reported as number and percentage, while continuous data were reported as mean ± SD. Multivariate linear regression was used to evaluate the association between influencing factors and breastfeeding knowledge. The overall mean score of the 460 returned questionnaires was 43.991 out of 100. The pass rate of the questionnaire was only 23.04%. Nursing undergraduates had a relatively better grasp of the benefits of breastfeeding and related advice (correct rates: 67.83%). Birthplace, only child or not, the course in obstetrics and gynecological nursing, the course in pediatrics nursing, and placements in maternity or neonatology units were relevant factors for breastfeeding knowledge (p < 0.05). Nursing undergraduates showed unsatisfactory breastfeeding knowledge. It is urgent to raise the knowledge level of breastfeeding among nursing undergraduates. Medical colleges should optimally structure a curriculum of breastfeeding knowledge. Furthermore, it is also necessary to improve the public’s understanding of breastfeeding and the whole society’s attention to breastfeeding in China.
Concordance between General Practitioners and Radiation Oncologists for Cancer Follow-Up Care
Authors: Sandell Tiffany , Miller Andrew , Schütze Heike
Published: December 2022

(1) Background: Patients treated with radiotherapy require follow-up care to detect and treat acute and late side effects, and to monitor for recurrence. The increasing demand for follow-up care poses a challenge for specialists and general practitioners. There is a perception that general practitioners do not have the specialised knowledge of treatment side effects and how to manage these. Knowing the concordance between general practitioner and oncologist clinical assessments can improve confidence in healthcare professionals. This study aimed to measure the level of agreement between general practitioners and radiation oncologists using a standardised clinical assessment; (2) Methods: a cross-sectional clinical practice study; sample aim of 20 breast, prostate or colorectal patients, three years post-radiotherapy treatment; their general practitioner and radiation oncologist; (3) Results: There was acceptable percent agreement (>75%) and a moderate to almost perfect agreement (Fleiss kappa) for all variables between the 15 general practitioner-radiation oncologist dyads; (4) Conclusions: The general practitioner and radiation oncologist concordance of a clinical follow-up assessment for radiation oncology patients is an important finding. These results can reassure both general practitioners and oncologists that general practitioners can provide cancer follow-up care. However, further studies are warranted to confirm the findings and improve reassurance for health professionals.
The Association between Apparent Temperature and Hospital Admissions for Cardiovascular Disease in Limpopo Province, South Africa
Authors: Bühler Jacqueline Lisa , Shrikhande Shreya , Kapwata Thandi , Cissé Guéladio , Liang Yajun , Pedder Hugo , Kwiatkowski Marek , Kunene Zamantimande , Mathee Angela , Peer Nasheeta , Wright Caradee Y.
Published: December 2022

Cardiovascular diseases (CVDs) have a high disease burden both globally and in South Africa. They have also been found to be temperature-sensitive globally. The association between temperature and CVD morbidity has previously been demonstrated, but little is known about it in South Africa. It is important to understand how changes in temperature in South Africa will affect CVD morbidity, especially in rural regions, to inform public health interventions and adaptation strategies. This study aimed to determine the short-term effect of apparent temperature (Tapp) on CVD hospital admissions in Mopani District, Limpopo province, South Africa. A total of 3124 CVD hospital admissions records were obtained from two hospitals from 1 June 2009 to 31 December 2016. Daily Tapp was calculated using nearby weather station measurements. The association was modelled using a distributed lag non-linear model with a negative binomial regression over a 21-day lag period. The fraction of morbidity attributable to non-optimal Tapp, i.e., cold (6–25 °C) and warm (27–32 °C) Tapp was reported. We found an increase in the proportion of admissions due to CVDs for warm and cold Tapp cumulatively over 21 days. Increasing CVD admissions due to warm Tapp appeared immediately and lasted for two to four days, whereas the lag-structure for the cold effect was inconsistent. A proportion of 8.5% (95% Confidence Interval (CI): 3.1%, 13.7%) and 1.1% (95% CI: −1.4%, 3.5%) of the total CVD admissions was attributable to cold and warm temperatures, respectively. Warm and cold Tapp may increase CVD admissions, suggesting that the healthcare system and community need to be prepared in the context of global temperature changes.
Genome-Wide Analysis of the Rab Gene Family in Melilotus albus Reveals Their Role in Salt Tolerance
Authors: Zhang Caibin , Wu Fan , Yan Qi , Duan Zhen , Wang Shengsheng , Ao Bao , Han Yangyang , Zhang Jiyu
Published: December 2022

Melilotus albus is a high-quality forage, due to its high protein content, and aboveground biomass and salt tolerance. Rab (Ras-related protein in the brain) proteins are the largest GTPase family which play a key role in intracellular membrane transport, and many Rab genes have been identified in eukaryotes. The growth and distribution of M. albus are severely hampered by soil salinization. However, little is known about candidate genes for salt tolerance in M. albus. In this study, 27 Rab family genes were identified for the first time from M. albus, and divided into eight groups (Groups A-H). The number of introns in MaRabs ranged from one to seven, with most genes containing one intron. In addition, most MaRab proteins showed similarities in motif composition. Phylogenetic analysis and structural-domain comparison indicated that Rab family genes were highly conserved in M. albus. Members of the MaRab gene family were distributed across all eight chromosomes, with the largest distribution on chromosome 1. Prediction of the protein interaction network showed that 24 Rab proteins exhibited protein–protein interactions. Analysis of the promoter cis-acting elements showed that MaRab-gene family members are extensively involved in abiotic stress responses. RNA-seq data analysis of the MaRab-gene-expression patterns suggested that the Rab gene family possesses differentially expressed members in five organs and under salt stress, drought stress, and ABA (Abscisic Acid) treatment. Differentially expressed genes under drought stress, salt stress and ABA stress were validated by quantitative real-time PCR. Furthermore, heterologous expression in yeast was used to characterize the functions of MaRab1 and MaRab17, which were upregulated in reaction to salt stress. In summary, this study provided valuable information for further research into the molecular mechanism of the response of M. albus to saline stress, as well as the possibility of developing cultivars with high salt-resistance characteristics.
Diagnosis by Volatile Organic Compounds in Exhaled Breath from Patients with Gastric and Colorectal Cancers
Authors: Chung Jinwook , Akter Salima , Han Sunhee , Shin Yoonhwa , Choi Tae , Kang Insug , Kim Sung
Published: December 2022

One in three cancer deaths worldwide are caused by gastric and colorectal cancer malignancies. Although the incidence and fatality rates differ significantly from country to country, the rates of these cancers in East Asian nations such as South Korea and Japan have been increasing each year. Above all, the biggest danger of this disease is how challenging it is to recognize in its early stages. Moreover, most patients with these cancers do not present with any disease symptoms before receiving a definitive diagnosis. Currently, volatile organic compounds (VOCs) are being used for the early prediction of several other diseases, and research has been carried out on these applications. Exhaled VOCs from patients possess remarkable potential as novel biomarkers, and their analysis could be transformative in the prevention and early diagnosis of colon and stomach cancers. VOCs have been spotlighted in recent studies due to their ease of use. Diagnosis on the basis of patient VOC analysis takes less time than methods using gas chromatography, and results in the literature demonstrate that it is possible to determine whether a patient has certain diseases by using organic compounds in their breath as indicators. This study describes how VOCs can be used to precisely detect cancers; as more data are accumulated, the accuracy of this method will increase, and it can be applied in more fields.
Hispolon Methyl Ether, a Hispolon Analog, Suppresses the SRC/STAT3/Survivin Signaling Axis to Induce Cytotoxicity in Human Urinary Bladder Transitional Carcinoma Cell Lines
Authors: Kuo Min-Yung , Yang Wei-Ting , Ho Yann-Jen , Chang Ge-Man , Chang Hsiung-Hao , Hsu Chao-Yu , Chang Chia-Che , Chen Yi-Hsin
Published: December 2022

Bladder cancer is a leading human malignancy worldwide. Signal transducer and activator of transcription (STAT) 3 is an oncogenic transcription factor commonly hyperactivated in most human cancers, including bladder cancer. Notably, preclinical evidence has validated STAT3 blockade as a promising therapeutic strategy for bladder cancer. Hispolon Methyl Ether (HME) is a structural analog of hispolon, an anticancer component of the medicinal mushroom Phellinus linteus. Thus far, HME’s anticancer activity and mechanisms remain largely unknown. We herein report HME was cytotoxic, more potent than cisplatin, and proapoptotic to various human bladder transitional carcinoma cell lines. Of note, HME blocked STAT3 activation, evidenced by HME-elicited reduction in tyrosine 705-phosphorylated STAT3 levels constitutively expressed or induced by interleukin-6. Significantly, HME-induced cytotoxicity was abrogated in cells expressing a dominant-active STAT3 mutant (STAT3-C), confirming STAT3 blockage as a pivotal mechanism of HME’s cytotoxic action. We further revealed that survivin was downregulated by HME, while its levels were rescued in STAT3-C-expressing cells. Moreover, survivin overexpression abolished HME-induced cytotoxicity, illustrating survivin as a central downstream mediator of STAT3 targeted by HME. Lastly, HME was shown to lower tyrosine 416-phosphorylated SRC levels, suggesting that HME inhibits STAT3 by repressing the activation of SRC, a STAT3 upstream kinase. In conclusion, we present the first evidence of HME’s anti-bladder cancer effect, likely proceeding by evoking apoptosis through suppression of the antiapoptotic SRC/STAT3/survivin signaling axis.
Evaluation of Exosomal Coding and Non-Coding RNA Signature in Obese Adolescents
Authors: Cabiati Manuela , Randazzo Emioli , Guiducci Letizia , Falleni Alessandra , Cecchettini Antonella , Casieri Valentina , Federico Giovanni , Del Ry Silvia
Published: December 2022

Exosomes may contribute to the pathogenesis of obesity through their action as communication mediators. As we have previously demonstrated, in obese adolescents, some circulating miRNAs modified the C-type natriuretic peptide (CNP) expression and were associated with changes in metabolic functions. At present no data are available on miRNA transport by exosomes in this condition. To verify and compare the presence and the expression of CNP/NPR-B/NPR-C, and some miRNAs (miR-33a-3p/miR-223-5p/miR-142-5p/miRNA-4454/miRNA-181a-5p/miRNA-199-5p), in circulating exosomes obtained from the same cohort of obese (O, n = 22) and normal-weight adolescents (N, n = 22). For the first time, we observed that exosomes carried CNP and its specific receptors only randomly both in O and N, suggesting that exosomes are not important carriers for the CNP system. On the contrary, exosomal miRNAs resulted ubiquitously and differentially expressed in O and N. O showed a significant decrease (p < 0.01) in the expression of all miRNAs except for miR-4454 and miR-142-5p. We have found significant correlations among miRNAs themselves and with some inflammatory/metabolic factors of obesity. These relationships may help in finding new biomarkers, allowing us to recognize, at an early stage, obese children and adolescents at high risk to develop the disease complications in adult life.
Updates on the Role of Probiotics against Different Health Issues: Focus on Lactobacillus
Authors: Un-Nisa Arifa , Khan Amjad , Zakria Muhammad , Siraj Sami , Ullah Shakir , Tipu Muhammad Khalid , Ikram Muhammad , Kim Myeong Ok
Published: December 2022

This review article is built on the beneficial effects of Lactobacillus against different diseases, and a special focus has been made on its effects against neurological disorders, such as depression, multiple sclerosis, Alzheimer’s, and Parkinson’s disease. Probiotics are live microbes, which are found in fermented foods, beverages, and cultured milk and, when administered in an adequate dose, confer health benefits to the host. They are known as “health-friendly bacteria”, normally residing in the human gut and involved in maintaining homeostatic conditions. Imbalance in gut microbiota results in the pathophysiology of several diseases entailing the GIT tract, skin, immune system, inflammation, and gut–brain axis. Recently, the use of probiotics has gained tremendous interest, because of their profound effects on the management of these disease conditions. Recent findings suggest that probiotics enrichment in different human and mouse disease models showed promising beneficial effects and results in the amelioration of disease symptoms. Thus, this review focuses on the current probiotics-based products, different disease models, variable markers measured during trials, and evidence obtained from past studies on the use of probiotics in the prevention and treatment of different diseases, covering the skin to the central nervous system diseases.