bluuebunny/crossref_metadata_2025 huggingface dataset:
Improving Research Practice in Rat Orthotopic and Partial Orthotopic Liver Transplantation: A Review, Recommendation, and Publication Guide
Authors: Czigány Zoltán , Iwasaki Junji , Yagi Shintaro , Nagai Kazuyuki , Szijártó Attila , Uemoto Shinji , Tolba René H.
Published: July 2015

Background: Due to a worldwide shortage of donor organs for liver transplantation, alternative approaches, such as split and living donor liver transplantations, were introduced to increase the donor pool and reduce mortality on liver transplant waiting lists. Numerous details concerning the mechanisms and pathophysiology of liver regeneration, small-for-size syndrome, rejection, and tolerance in partial liver transplantation facilitated the development of various animal models. The high number of preclinical animal studies contributed enormously to our understanding of many clinical aspects of living donor and partial liver transplantations. Summary: Microsurgical rat models of partial orthotopic liver transplantation are well established and widely used. Nevertheless, several issues regarding this procedure are controversial, not clarified, or not yet properly standardized (graft rearterialization, size reduction techniques, etc.). The major aim of this literature review is to give the reader a current overview of rat orthotopic liver transplantation models with a special focus on partial liver transplantation. The aspects of model evolution, microsurgical training, and different technical problems are analyzed and discussed in detail. Our further aim in this paper is to elaborate a detailed publication guide in order to improve the quality of reporting in the field of rat liver transplantation according to the ARRIVE guidelines and the 3R principle. Key Messages: Partial orthotopic liver transplantation in rats is an indispensable, reliable, and cost-efficient model for transplantation research. A certain consensus on different technical issues and a significant improvement in scientific reporting are essential to improve transparency and comparability in this field as well as to foster refinement.
Metastatic Fibrolamellar Hepatocellular Carcinoma to the Pancreas
Authors: Villa Nicolas A. , Pannala Rahul , Faigel Douglas O. , Haakinson Danielle J. , Katariya Nitin , Ramanathan Ramesh , Jaroszewski Dawn , Lidner Thomas K. , Byrne Thomas
Published: July 2015

Fibrolamellar hepatocellular carcinoma (FL-HCC) is a rare variant of hepatocellular carcinoma, usually presenting in the younger population (<40 years) without underlying liver disease. Although it has a better prognosis than hepatocellular carcinoma, it has a high rate of recurrence months to years after primary resection. While sites of recurrence usually involve the liver, regional lymph nodes, peritoneum, and lung, metastasis to the pancreas is extremely rare, with only 2 other cases reported in the literature. We present the case of a 46-year-old patient with metastatic FL-HCC to the pancreas 30 years after diagnosis and 26 years since his last resected liver recurrence.
Familial Disorders of the Optic Disc: Presentation of a Mother and Daughter and Review of the Literature
Authors: Hsu Chia Lee , Layton Christopher J.
Published: July 2015

Optic disc pit and optic nerve coloboma are examples of congenital optic disc abnormalities. Although optic nerve coloboma can be inherited in an autosomal dominant fashion, no conclusive link has been found in the case of optic disc pit as an autosomal dominant disease. We describe two cases: a daughter with an optic disc pit complicated by maculopathy and her mother with a congenitally abnormal optic disc complicated by peripapillary choroidal neovascularisation.
Blue Rubber Bleb Nevus Syndrome Showing Vascular Skin Lesions Predominantly on the Face
Authors: Korekawa Ayumi , Nakajima Koji , Aizu Takayuki , Nakano Hajime , Sawamura Daisuke
Published: July 2015

An 81-year-old Japanese man presented with dark blue papules and nodules on his face. There were multiple soft papules and nodules, dark blue in color, compressive, and ranging in size from 2 to 10 mm. A few similar lesions were seen on the patient's right dorsal second toe and right buccal mucosa. There were no skin lesions on his trunk and upper limbs. The patient's past history did not include gastrointestinal bleeding or anemia. Histopathological examination showed dilated vascular spaces lined by the normal epithelium extending beneath the dermis and into the subcutaneous fat. Endoscopy of the gastrointestinal tract to check for colon involvement was not performed. X-ray images of the limbs revealed no abnormalities in the bones or joints. Laboratory investigations did not show anemia. Although we failed to confirm a diagnosis by endoscopy, the skin lesions, histopathological findings, lack of abnormal X-ray findings, and the presence of oral lesions as a part of gastrointestinal tract guided the diagnosis of blue rubber bleb nevus syndrome (BRBNS). Skin lesions of BRBNS occur predominantly on the trunk and upper limbs. However, the present case showed multiple skin lesions predominantly on the face. Therefore, it is important for clinicians to know about a possible atypical distribution of skin lesions in BRBNS.
The Bailey-Derek Grammar: Recording the Craft of Wire-Bending in the Trinidad Carnival
Authors: Noel Vernelle A.A.
Published: July 2015

This paper presents work on the development of a shape grammar that records the dying, undocumented craft of wire-bending in the Trinidad Carnival. This craft is important for the building and continuation of cultural heritage and identity. Due to the lack of prior research in this non-Western design practice, the author conducted site visits, interviews and observations, and visually examined wire-bent artifacts in Trinidad to develop this grammar. This paper presents the materials, steps and shape rules that begin to synthesize the craft, as well as one design. This study and the resulting grammar have positive implications for design education and practice.
Light Pattern: Writing Code with Photographs
Authors: Temkin Daniel
Published: July 2015

This paper explores the author’s Light Pattern project, a programming language where code is written with photographs rather than text. Light Pattern explores programming languages as the most direct conduit between human thinking and machine logic. It emphasizes the nuance, tone and personal style inherent in all code. It also creates an algorithmic photography structured by the programs one writes, but not ultimately computer-generated. The paper looks at connections to both hobbyist/hacker culture (specifically esolangs) and to art-historical impulses and movements such as Fluxus and Oulipo.
Quercus rajushkinae, a new name for Quercus lavrovii Rajushkina (Fagaceae)
Authors: Doweld Alexander Borisovitch
Published: July 2015

The fossil species Quercus lavrovii Rajushkina (1987: 146) was described on the fossil leaf remains of an oak from the Miocene sediments of Dzhungarian Aktau, Ili depression (Kazakhstan, Central Asia). However, according to Art. 53.1 of ICN (McNeill et al. 2012) this name is illegitimate because of the existence of an overlooked earlier homonym, Quercus lavrovii Budantsev (1955: 93) which was originally described from the earlier Oligocene deposits of Bestau, Turgay (Kazakhstan). The homonymy between these fossil species emerged during the creation of the International Fossil Plant Names Index, which is planned to list all fossil plant species (IFPNI 2014 onwards). Since the preoccupied species P. lavrovii Rajushk. is systematically recognized as a valid species in current use and it does not have any synonym, a nomen novum, Q. rajushkinae, is here formally proposed as a replaced name.
Tricharina tophiseda—a new species from Croatia, with a revision of T. japonica (Pyronemataceae, Pezizales)
Authors: Kušan Ivana , Matočec Neven , Mešić Armin , Tkalčec Zdenko
Published: July 2015

A new species, Tricharina tophiseda, is described in detail on the basis of both teleomorph and anamorph states. A comparative study of the most similar species, T. japonica, is provided by re-examination of the holotype and recently collected European material. Highly diverse characters of species in Tricharina and closely related genera demonstrate concurrence with polyphyly ascertained by a number of previous phylogenetic studies.
An enigmatic species of Croton (Euphorbiaceae) is rediscovered after more than 100 years in midwestern Brazil
Authors: SILVA MARCOS J. DA , Sodré Rodolfo Carneiro , BERRY PAUL E.
Published: July 2015

Croton spica, an enigmatic species of Croton, was newly recollected after more than 100 years and is herein redescribed, including fruits and seeds, and illustrated for the first time. The species was described by Henri Baillon in 1864 and is part of a complex of similar species that includes C. abaitensis, C. agoensis, C. longinervius, C. mucronifolius and C. pycnadenius, all of which occur predominantly in the Brazilian Planalto. A detailed description, illustration, photographs, distribution, habitat, phenology, IUCN Red List Category, morphological relationships, and a key to Croton spica and allied species are provided.
Brounea, a new genus (Coleoptera: Staphylinidae: Pselaphinae) from New Zealand, with descriptions of nine new species
Authors: PARK JONG-SEOK , CARLTON CHRISTOPHER E.
Published: July 2015

A new genus and nine new species of New Zealand endemic pselaphine staphylinid beetles belonging to the supertribe Faronitae are described: Brounea Park & Carlton, gen. nov. (type species: Sagola setiventris Broun, 1915); B. yoonhoi Park & Carlton, sp. nov., B. chorui Park & Carlton, sp. nov., B. sungryongi Park & Carlton, sp. nov., B. mijeongae Park & Carlton sp. nov., B. seongmoi Park & Carlton sp. nov., B. daehyuni Park & Carlton sp. nov., B. mangamukaensis Park & Carlton sp. nov., B. sunjaei Park & Carlton sp. nov., and B. seungili Park & Carlton sp. nov. Two species, S. setiventris and S. tenuis Broun, 1886, are transferred to the genus Brounea. A key to species, habitus photographs, and line drawings of diagnostic characters are provided.
Review of the genus Arboridia Zachvatkin (Hemiptera: Cicadellidae: Typhlocybinae), with description of two new species from China
Authors: SONG YUE-HUA , LI ZI-ZHONG
Published: July 2015

The genus Arboridia Zachvatkin is reviewed, including two new species Arboridia cincta sp.nov. and Arboridia ochracea sp.nov., from Henan province, China. A detailed morphological description and illustrations of the two new species are provided. A key to all known species from China is given.
Two new endemic Hawai‘ian Lepidoptera: a new species of Pseudoschrankia (Erebidae) from O‘ahu, and a new species of Thyrocopa (Xyloryctidae) from Moloka‘i
Authors: MEDEIROS MATTHEW J
Published: July 2015

Two new endemic Hawai‘ian Lepidoptera species are herein described. The first, Pseudoschrankia brevipalpis sp. nov., is a pollinator of the rare endemic plant Schiedea kaalae Wawra. The second, Thyrocopa keliae sp. nov., is endemic to Moloka‘i island. Observations of undescribed parasitic mites that attack Hawai‘ian Lepidoptera are presented as well.
Ще раз про походження літописного Вердерева
Authors: Шульгач [Shul'gach] Віктор [Viktor] П. [P.]
Published: July 2015

Ethymology of the place name Вердеревъ The oiconym Вердеревъ is mentioned in a document from the end of the 14th century. The historical place name is connected with today's name of a village in Skopin region, Riazan district. Some scientists observe a connection between the name with a hydronym Вердa (V.P. Neroznak, M.H. Tyhomyrov, M.A. Yuyukin). This explanation was called into question by the author: he proves that the oiconym Вердерев needs to be connected with a toponym Верх Дерево and adduces numerous similar geographic names in Slavic lands. Ещё раз об этимoлогии ойконима ВердеревъНазвание Вердеревъ упоминается в списке наименований городов российских от XIV в. Историческое летописное название связано с названием поселения, находящегося в Скопинском районе Рязанской области. По мнению некоторых учёных (Нерознак, Tихoмиpoв, Ююкин) данное название надо связывать с гидронимом Верда. Автор статьи предлагает другое толкование, считая, что ойконим Вердеревъ следует рассматривать в связи с топонимом Верх Дерево. На подтвержление своего мнения автор приводит ряд подобных географических названий, зафиксированных на всей славянской территории.
Język polski na Uniwersytecie Łotewskim w Rydze
Authors: Miseviča-Trilliča Renāte
Published: July 2015

The Polish language at the Latvian University in RigaThe history of teaching of Polish language in the University of Latvia (LU) starts soon after its establishment in 1919. In the 1930s thanks to such famous scientists as Julian Krzyżanowski and Stanisław Kolbuszewski, the number of subjects connected with the Polish culture has increased at the Faculty of Philology and Philosophy and the Latvian society was introduced to the numerous works of these professors, published in different publications in Latvia. After the Second World War, Polish language has been taught within Russian philology with the aim of comparison Eastern and Western Slavic language groups. At the same time scientific works on the state of Polish language of local Poles started to appear. Since the 1990s students of Russian Philology of the LU study Polish language as the foreign language by acquiring not only the structure of it for comparative purposes, but also by acquiring communicative skills. Due to the intensive cooperation with the Polish institutions, exchange programmes and the interest of the students, Polish language as the foreign language occupies a stable place among the courses of Bachelor programme of Russian philology in the LU.
Predictability of the California Niño/Niña*
Authors: Doi Takeshi , Yuan Chaoxia , Behera Swadhin K. , Yamagata Toshio
Published: July 2015

Predictability of a recently discovered regional coupled climate mode called the California Niño (Niña) off Baja California and California is explored using a seasonal prediction system based on the Scale Interaction Experiment-Frontier, version 1 (SINTEX-F1) coupled ocean–atmosphere general circulation model. Because of the skillful prediction of basin-scale El Niño (La Niña), the California Niño (Niña) that co-occurs with El Niño (La Niña) with a peak in boreal winter is found to be predictable at least a couple of seasons ahead. On the other hand, the regional coupled phenomenon peaking in boreal summer without co-occurrence with El Niño (La Niña) is difficult to predict. The difficulty in predicting such an intrinsic regional climate phenomenon may be due to model deficiency in resolving the regional air–sea–land positive feedback processes. The model may also underestimate coastal Kelvin waves with a small offshore scale, which may play an important role in the generation of the California Niño/Niña. It may be improved by increasing horizontal resolution of the ocean component of the coupled model. The present study may provide a guideline to improve seasonal prediction of regional climate modes for important industrial as well as social applications.
Anthropogenic Weakening of the Tropical Circulation: The Relative Roles of Direct CO2 Forcing and Sea Surface Temperature Change
Authors: He Jie , Soden Brian J.
Published: July 2015

There is a lack of consensus on the physical mechanisms that drive the anthropogenic weakening of tropical circulation. This study investigates the relative roles of direct CO2 forcing, mean SST warming, and the pattern of SST change on the weakening of the tropical circulation using an ensemble of AMIP and aquaplanet simulations. In terms of the mean weakening of the tropical circulation, the SST warming dominates over the direct CO2 forcing through its control over the tropical mean hydrological cycle and tropospheric stratification. In terms of the spatial pattern of circulation weakening, however, the three forcing agents are all important contributors, especially over the ocean. The increasing CO2 weakens convection over ocean directly by stabilizing the lower troposphere and indirectly via the land–sea warming contrast. The mean SST warming drives strong weakening over the centers and edges of convective zones. The pattern of SST warming plays a crucial role on the spatial pattern of circulation weakening over the tropical Pacific.

The anthropogenic weakening of the Walker circulation is mostly driven by the mean SST warming. Increasing CO2 strengthens the Walker circulation through its indirect effect on land–sea warming contrast. Changes in the upper-level velocity potential indicate that the pattern of SST warming does not weaken the Walker circulation despite being “El Niño–like.” A weakening caused by the mean SST warming also dominates changes in the Hadley circulation in the AMIP simulations. However, this weakening is not simulated in the Southern Hemisphere in coupled simulations.
The Impact of Range-Oversampling Processing on Tornado Velocity Signatures Obtained from WSR-88D Superresolution Data
Authors: Torres Sebastián M. , Curtis Christopher D.
Published: July 2015

WSR-88D superresolution data are produced with finer range and azimuth sampling and improved azimuthal resolution as a result of a narrower effective antenna beamwidth. These characteristics afford improved detectability of weaker and more distant tornadoes by providing an enhancement of the tornadic vortex signature, which is characterized by a large low-level azimuthal Doppler velocity difference. The effective-beamwidth reduction in superresolution data is achieved by applying a tapered data window to the samples in the dwell time; thus, it comes at the expense of increased variances for all radar-variable estimates. One way to overcome this detrimental effect is through the use of range oversampling processing, which has the potential to reduce the variance of superresolution data to match that of legacy-resolution data without increasing the acquisition time. However, range-oversampling processing typically broadens the radar range weighting function and thus degrades the range resolution. In this work, simulated Doppler velocities for vortexlike fields are used to quantify the effects of range-oversampling processing on the velocity signature of tornadoes when using WSR-88D superresolution data. The analysis shows that the benefits of range-oversampling processing in terms of improved data quality should outweigh the relatively small degradation to the range resolution and thus contribute to the tornado warning decision process by improving forecaster confidence in the radar data.
Time–Space SST Variability in the Atlantic during 2013: Seasonal Cycle
Authors: Liu Liyan , Lozano Carlos , Iredell Dan
Published: July 2015

A 2-yr-long daily gridded field of sea surface temperature (SST) in the Atlantic centered for the year 2013 is projected onto orthogonal components: its mean, six harmonics of the year cycle, the slow-varying contribution, and the fast-varying contribution. The periodic function defined by the year harmonics, referred to here as the seasonal harmonic, contains most of the year variability in 2013. The seasonal harmonic is examined in its spatial and temporal distribution by describing the amplitude and phase of its maxima and minima, and other associated parameters. In the seasonal harmonic, the ratio of the duration of warming period to cooling period ranges from 0.2 to 2.0. There are also differences in the spatial patterns and dominance of the year harmonics—in general associated with regions with different insolation, oceanic, and atmospheric regimes. Empirical orthogonal functions (EOFs) of the seasonal harmonic allow for a succinct description of the seasonal evolution for the Atlantic and its subdomains. The decomposition can be applied to model output, allowing for a more incisive model validation and data assimilation. The decorrelation time scale of the rapidly varying signal is found to be nearly independent of the time of the year once four or more harmonics are used. The decomposition algorithm, here implemented for a single year cycle, can be applied to obtain a multiyear average of the seasonal harmonic.
A Review Over the Past 15 Years of the Management of the Internal Piriform Apex Sinus Tract of a Branchial Pouch Anomaly and Case Description
Authors: Josephson Gary D. , Black Kaelan
Published: July 2015

Objectives:

Literature review of treating the piriform apex sinus tract through microlaryngoscopy and a case description.

Review Methods:

Fourteen papers were identified in PubMed using the search criteria of piriform sinus fistula, microlaryngoscopic repair, and endoscopy. Institutional Review Board approval was obtained.

Results:

One hundred forty-five cases including ours were available for review, with 182 procedures. Sixty-two cases were male, 73 female, and 10 genders were not reported. Multiple treatment options were used, including electrocautery, chemocautery, mass excision, fibrin glue, lasers, suture closure, or combination of stated modalities. Of the 182 procedures, 147 procedures were performed endoscopically. There were 37 recurrences (25%). These patients either underwent a repeat endoscopic procedure or an open excision. One hundred and ten (75%) endoscopic procedures were successful.

Conclusions:

Piriform sinus tract anomalies often present as a mass and recurrent neck infections. This review reveals that treating the internal piriform sinus opening alone can be successful. This procedure has low morbidity, short operative time, and high success. We advocate this approach first with a combined open/laryngoscopic approach for failed cases. To our knowledge, our technique of CO2 laser ablation of the tract followed by suture closure has not been previously described. We believe this to be the first comprehensive review of this topic and the largest series of cases included in a single report.
Intraoperative Ultrasonography During Transoral Robotic Surgery
Authors: Clayburgh Daniel R. , Byrd J. Kenneth , Bonfili Jennifer , Duvvuri Umamaheswar
Published: July 2015

Objective:

This study describes the potential application of intraoperative ultrasound imaging during transoral robotic surgery (TORS).

Methods:

Ultrasound imaging was performed during transoral robotic resection of oropharyngeal tumors in 10 patients at a tertiary academic center. Ultrasound imaging was utilized to identify large-caliber vessels adjacent to the surgical site. Measurements were also taken on the ultrasound of tumor thickness to determine the deep margin. Following resection, the tumor was sectioned, and a gross measurement of the tumor thickness was obtained.

Results:

Intraoperative ultrasound use led to the identification of larger-caliber blood vessels within the operative field prior to encountering them visually. Ultrasound could also aid in defining deep tumor margins; the tumor thickness measured via ultrasound was found to be accurate within 1 to 2 mm of the grossly measured tumor thickness. This allowed for focused, careful dissection to protect and avoid blood vessels during dissection as well as improved tumor resection.

Conclusions:

The use of intraoperative ultrasound provides additional information to the head and neck surgeon during TORS. This may be used to identify blood vessels and assess tumor margins, thereby improving the safety and efficacy of TORS.
An investigation of attitudes towards tax evasion and welfare fraud in New Zealand
Authors: Marriott Lisa
Published: July 2015

This study undertakes an empirical exploration of attitudes towards tax evasion and welfare fraud in New Zealand. Prior research indicates that society has different attitudes towards these two crimes. However, it is not known why this is the case, particularly as both crimes are conceptually similar. The study has two aims. The first is to measure the extent to which society views tax evasion and welfare fraud differently in New Zealand. The second, and primary, objective of this research is to offer an explanation for why different views exist. The dual-process model, using social dominance orientation and right-wing authoritarianism is used for analytical purposes. Responses from 1500 survey participants show that New Zealanders do have different attitudes towards welfare fraud and tax evasion. In contrast to previous research findings, this study shows that harsher attitudes are held towards tax evasion than welfare fraud. Education and income level provide the greatest level of significance in explaining attitudes towards welfare fraud; and age and income source provide the greatest level of significance in explaining attitudes towards tax evasion.
Silencing Critics
Authors: Kellam Marisa , Stein Elizabeth A.
Published: July 2015

The media hold democratically elected leaders accountable by exposing corruption and policy failures. Although many politicians accept media criticism as intrinsic to liberal democracy, some politicians rein in freedom of the press or intimidate media outlets to silence their critics. We identify circumstances that motivate and enable presidents to curb media freedom in presidential democracies. We argue that (a) presidents who hold ideological positions contrary to those of the mainstream media adopt the media as viable opponents in the absence of an effective electoral opposition, and (b) the media are vulnerable to presidential infringements on their freedom where legislatures and judiciaries hold weak powers relative to presidents, and are therefore unable to constrain presidents’ actions against media freedom. We support our argument with quantitative analyses of press freedom ratings in presidential and semi-presidential democracies from 1993 to 2013.
Europe’s perennial ‘outsiders’: A processual approach to Roma stigmatization and ghettoization
Authors: Powell Ryan , Lever John
Published: July 2015

This article draws on the theoretical work of Norbert Elias and Loïc Wacquant in seeking to understand the stigmatized and marginalized position of the Roma population within Europe. The article argues that the persistent persecution of Roma, reflected in social policy, cannot be understood without reference to long-term social processes which shape the nature of the asymmetric power relations between Roma and non-Roma. Elias’s theory of established–outsider relations is applied at the intra-state European level in arguing that Roma constitute a cross-border ‘outsider’ group; with their intense stigmatization explained and perpetuated by a common set of collective fantasies which are maintained through complex group processes of disidentification, and which result in Roma being seen as of lesser human worth. Wacquant’s theoretical concept of the ‘ghetto’ is then drawn upon to show how the manifestations of stigmatization for the stigmatized are at once psychological, social and spatial. The article suggests that the synthesis of the two theorists’ concepts allows for an approach that can expose the way in which power is exercised within and through group relations. Such an approach emphasizes the centrality of the interdependence between Roma and non-Roma, and the fluctuating power balance that characterizes that relationship across time and space. The article concludes that, while existing research focused on policy and outcomes is useful in understanding the negative contemporary experiences of Roma populations, they need to be understood in the context of wider social processes and historical continuities in seeking to elucidate how these processes shape policies and contribute to social and spatial marginalization.
Preparation and properties of an organic–inorganic composite superabsorbent based on attapulgite
Authors: Ma Guofu , Ran Feitian , Feng Enke , Zhang Zhe , Lei Ziqiang
Published: July 2015

A novel, low-cost, and eco-friendly organic–inorganic composite superabsorbent is successfully prepared in aqueous solution by graft copolymerization of partially neutralized acrylic acid (AA), polyvinyl alcohol (PVA), and attapulgite (APT) using ammonium persulfate (APS) as an initiator and N, N-methylenebisacrylamide (MBA) as a crosslinker. The structure and morphology of the composite superabsorbent are characterized by means of Fourier transform infrared, X-ray diffraction, field-emission scanning electron microscopy, and transmission electron microscopy. The effects of APT content which can affect the water absorbency and the pH, ionic surfactants and different saline solution which can affect swelling capabilities of the composite superabsorbent are also investigated. The results show the composite superabsorbent give the best absorption up to 680 g/g and 53 g/g in distilled water and 0.9 wt% NaCl solution, high water absorbency over a wide pH range of 4–10, high swelling capacity in anionic surfactant than that of cationic solution, which makes it promising for potential applications in modern agriculture and horticulture. On the other hand, the composite superabsorbent can be used for removing multivalent metal ions.
Effectiveness of Lateral Bone Augmentation on the Alveolar Crest Dimension
Authors: Sanz-Sánchez I. , Ortiz-Vigón A. , Sanz-Martín I. , Figuero E. , Sanz M.
Published: July 2015

Lateral ridge augmentation procedures are aimed to reconstruct deficient alveolar ridges or to build up peri-implant dehiscence and fenestrations. The objective of this systematic review was to assess the efficacy of these interventions by analyzing data from 40 clinical studies evaluating bone augmentation through either the staged or the simultaneous approach. The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) guideline for systematic reviews was used. The primary outcomes were the changes at reentry, in the ridge width, and in the vertical and horizontal dimensions of the peri-implant defect, measured in millimeters, in the staged and simultaneous approaches, respectively. The results of the meta-analysis showed, for the simultaneous approach, a statistically significant defect height reduction when all treatments were analyzed together (weighted mean difference [WMD] = −4.28 mm; 95% confidence interval: [CI] –4.88, –3.69; P < 0.01). The intervention combining bone replacement grafts with barrier membranes was associated with superior outcomes The most frequently used intervention was the combination of xenograft and bioabsorbable membrane. Similarly, for the staged approach, there was a statistically significant horizontal gain when all treatment groups were combined (WMD = 3.90 mm; 95% CI: 3.52, 4.28; P < 0.001). The most frequently used intervention was the use of autogenous bone blocks. Both treatment strategies led to high survival and success rates (>95%) for the implants placed on the regenerated sites. Nonexposed sites gained significantly more in the simultaneous and staged approaches (WMD = 1.1 and 3.1 mm).
Competence- and Integrity-Based Trust in Interorganizational Relationships: Which Matters More?
Authors: Connelly Brian L. , Crook T. Russell , Combs James G. , Ketchen David J. , Aguinis Herman
Published: July 2015

Trust is an important factor for managing transaction costs within interorganizational relationships (IORs). Research on trust indicates that separate dimensions of trust arise from a partner’s competence (i.e., technical skills, experience, and reliability) and integrity (i.e., motives, honesty, and character), and that these dimensions have potentially unique effects. Because scholars rarely apply this distinction within IOR research, past studies may have masked important relationships involving competence- and integrity-based trust. In response, we build and test theory that explains how competence- and integrity-based trust have asymmetric effects on different kinds of transaction costs. In particular, we build on theory that describes how parties process positive and negative information about others’ behavior to predict that integrity-based trust in IORs is more potent for reducing transaction costs than is competence-based trust. We also theorize that building strong IORs requires more up-front investment with competence-based but not with integrity-based trust. By applying meta-analytic structural equation modeling to data on 37,366 IORs drawn from 150 samples, we find that integrity-based trust is about 10 times more effective at reducing these costs. A key implication is that managers seeking to improve the efficiency of their IORs may do well by performing competently, but they can do even better by building perceptions of integrity.
Indian Paradigms of Political Authority and Usages of Urban Spaces: Comparative Analysis of Jaipur as an Eighteenth-century Example
Authors: Imam Fatima
Published: July 2015

This article critiques the current scholarship on Indian urbanization, which either provides social, economic and cultural histories of the Indian cities or offers religious models for the origins of the cities. The investigation of urbanization processes in the Jaipur state reveals the centrality of this aspect to the consolidation of sovereignty and its incorporation of diverse social groups. This article draws attention to the historically located factors that produced new forms of indigenous sovereignty and proposes that two imperial cities, Shahjahanabad (Delhi) and Jaipur, came close to this definition.
Book Review: Y. Subbarayalu, South India under the Cholas
Authors: Subbiah G.
Published: July 2015

Y. Subbarayalu, South India under the Cholas, Oxford University Press, New Delhi, 2012, Preface + i–xiv + 274 pp., ₹675.
Why should banks provide entrepreneurship training seminars?
Authors: Coad Alex , Frankish Julian S , Roberts Richard G , Storey David J
Published: July 2015

This article examines an apparent contradiction at the heart of the provision of management training and advice for new and small firms. Assessments using self-report data show high levels of satisfaction, implying that the training/advice is effective and appreciated. In contrast, assessments using robust statistical methods point to modest, or even zero, impact upon firm performance. Accordingly, our core research question explores whether there is an identifiable performance benefit of management training or whether impact is limited to emotional attachment to the training provider – reflected in enhanced loyalty. We test this by examining the effects of a bank seminar provided for new enterprises and find it had no significant effects on either the survival or sales growth of participants. However, those new enterprises who participated in the seminar were significantly less likely to switch to a rival bank, implying the seminars may have induced a feeling of loyalty among clients. Finally, we discuss the implications for theory, for the bank and for the providers of training for new and small firms more widely.
Cross Lineage Rearrangement in Feline Enteropathy-Associated T-cell Lymphoma
Authors: Andrews C. , Operacz M. , Maes R. , Kiupel M.
Published: July 2015

Feline enteropathy-associated T-cell lymphoma (EATL) type II is characterized by infiltration of the small intestinal mucosa with small T-cells with variable epitheliotropism and is often difficult to differentiate from inflammation. Polymerase chain reaction (PCR) to assess antigen receptor rearrangements (PARR) amplifies the T- (T-cell receptor gamma, TCRG) or B-cell (immunoglobulin heavy chain, IGH) antigen receptor genes and is used to differentiate EATL from inflammation. However, PARR does not determine lymphocyte phenotype, and clonal rearrangement of either or both the TCRG or IGH genes may be detected in neoplastic T-cells. The purpose of this study was to determine the incidence of cross lineage rearrangement in feline EATL type II. Using a diagnostic algorithm combining histology, immunohistochemistry, and PARR testing, 8 of 92 cases diagnosed as EATL type II at Michigan State University between January 2013 and June 2014 showed cross lineage rearrangement (8.7%). PARR for the IGH gene facilitates the diagnosis of cases histologically highly suggestive of EATL type II in which polyclonal rearrangement of the TCRG gene is detected.
Detrimental Effect of Repeated and Single Subacromial Corticosteroid Injections on the Intact and Injured Rotator Cuff
Authors: Maman Eran , Yehuda Chaim , Pritsch Tamir , Morag Guy , Brosh Tamar , Sharfman Zachary , Dolkart Oleg
Published: July 2015

Background:

The effect of corticosteroids on tendons is poorly understood, and current data are insufficient and conflicting.

Purpose:

To evaluate the effects of corticosteroid injections on intact and injured rotator cuffs (RCs) through biomechanical and radiographic analyses in a rat model.

Study Design:

Controlled laboratory study.

Methods:

A total of 70 rats were assigned to 7 groups. Uninjured rats (no tear) received either a single saline injection, a single methylprednisolone acetate (MTA) injection, or triple MTA injections. Injured rats (unilateral supraspinatus injury) received either a single saline injection, triple saline injections, a single MTA injection, or triple MTA injections (injections were subacromial; repeat injections were administered weekly). Rats were sacrificed 1 week after final injection. Shoulders were harvested and grossly inspected, and the supraspinatus tendon was evaluated biomechanically. Bone density at the tendon insertion site on the greater tuberosity was assessed by micro–computed tomography.

Results:

Intact RCs exposed to triple MTA injections had significantly decreased maximal load and stiffness compared with the control group (14.43 vs 21.25 N and 8.21 vs 16.6 N/mm, respectively; P < .05). Injured RCs exposed to steroid treatment had significantly lower maximal load (single saline: 10.91 N, single steroid: 8.43 N [ P < .05]; triple control: 15.77 N, triple steroid: 11.65 N [ P < .05]) compared with the control at 3 weeks. Greater tuberosity volume density and connectivity density were significantly lower in undamaged rats after triple MTA injection ( P < .05).

Conclusion:

The study results clearly showed that repeated doses of corticosteroids significantly weaken rat RC and negatively affect bone quality in addition to possibly causing deterioration of the osteotendinous junction. However, data retrieved from animals must be scrupulously analyzed before extrapolation to humans. As such, the potential benefits and harms of subacromial corticosteroid treatment must be considered before administration.

Clinical Relevance:

The potential benefit and detrimental effects of corticosteroid injection should be thoroughly considered before it is administered subacromially in patients with RC injuries.
In vitro differentiation of human amniotic epithelial cells into insulin-producing 3D spheroids
Authors: Okere Bernard , Alviano Francesco , Costa Roberta , Quaglino Daniela , Ricci Francesca , Dominici Massimo , Paolucci Paolo , Bonsi Laura , Iughetti Lorenzo
Published: July 2015

Regenerative medicine and stem cell therapy may represent the solution for the treatment of non-curable human diseases such as type 1 diabetes. In this context of growing demand for functional and safe stem cells, human amniotic epithelial cells (hAECs) from term placenta have attracted increasing interest for their wide availability, stem cell properties, and differentiation plasticity, which make them a promising tool for stem cell-based therapeutic applications. We initially assayed the stemness characteristics of hAECs in serum-free conditions. Subsequently we developed a culture procedure on extracellular matrix for the formation of three-dimensional (3D) spheroids. Finally, we tested the immunomodulation and differentiation potential of hAEC spheroids: the presence of pancreatic endocrine hormones was revealed with transmission electron microscopy and immunofluorescence analyses; the release of C-peptide in hyperglycemic conditions was assayed with ELISA.

The serum-free culture conditions we applied proved to maintain the basic stemness characteristics of hAECs. We also demonstrated that 3D spheroids formed by hAECs in extracellular matrix can be induced to differentiate into insulin-producing cells. Finally, we proved that control and induced cells equally inhibit the proliferation of activated mononuclear cells.

The results of this study highlight the properties of amnion derived epithelial cells as promising and abundant source for cell-based therapies. In particular we are the first group to show the in vitro pancreatic induction of hAECs cultured on extracellular matrix in a 3D fashion. We accordingly propose the outcomes of this study as a novel contribution to the development of future cell replacement therapies involving placenta-derived cells.
Evaluation of resistance to low pH and bile salts of human Lactobacillus spp. isolates
Authors: Fuochi Virginia , Petronio Giulio Petronio , Lissandrello Edmondo , Furneri Pio Maria
Published: July 2015

There are nearly 100 trillion bacteria in the intestine that together form the intestinal microbiota. They are ‘good’ bacteria because they help to maintain a physiological balance and are called probiotics. Probiotics must have some important characteristics: be safe for humans, be resistant to the low pH in the stomach, as well as bile salts and pancreatic juice. Indeed, their survival is the most important factor, so that they can arrive alive in the intestine and are able to form colonies, at least temporarily.

The aim of our study was the evaluation of resistance of Lactobacillus isolates from fecal and oral swabs compared to that found in a commercial product.

Seven strains were randomly chosen: L. jensenii, L. gasseri, L. salivarius, L. fermentum, L. rhamnosus, L. crispatus, and L. delbrueckii. We observed a large variability in the results: L. gasseri and L. fermentum were the most resistance to low pH, while only L. gasseri showed the best survival rate to bile salts. Interestingly, the commercial product did not show tolerance to both low pH and bile salts.
Human lymphocytic B-leukemia cell line treatment with the bacterial toxin listeriolysin O and rituximab (anti-CD20 antibody): Effects of similar localization of their receptors
Authors: Gryzik M , Grzywocz Z , Wasilewska D , Kawiak J , Stachowiak R , Bielecki J , Hoser G
Published: July 2015

Small B-cell lymphocytic lymphoma/chronic lymphocytic leukemia, which typically affects elderly people, is a group of conditions that are not clinically uniform. It has been suggested that using the combined activity of the monoclonal antibody anti-CD20 (rituximab) and Listeria monocytogenes toxin listeriolysin O (LLO) for this condition could produce an enhanced treatment effect. Here, we tested the effect of the joint activity of rituximab and LLO, which is a cell membrane toxin, in human leukemia cell lines. The human B-leukemia Raji cell line, which expresses CD20, and the T-cell Jurkat cell line, which does not express CD20, for comparison were used in model tests. Cell cytotoxicity of rituximab or LLO and both applied jointly to the cell lines was compared in the presence of human plasma complement. Optimal cytotoxic effects dependent on rituximab or LLO concentration were tested separately. LD50 values were determined and used for optimal application of a mixture of the two factors. The cytotoxic effect on Raji cells of both rituximab and LLO was more than 2.5 times that of LLO alone and 1.5 times that of rituximab alone. At the highest tested concentrations, a mixture of the tested factors had a non-specific cytotoxic effect on the Jurkat cell line, as well. The rituximab and LLO binding sites appear to be in a similar region of the Raji leukemia cell membrane, suggesting an effective interaction of both factors. The joint interaction of these compounds in cell membrane pore formation suggests an explanation for the more effective cytotoxic activity that their combination was observed in this experiment.
Supplemental Mathematics Intervention
Authors: Hunt Jessica H. , Valentine Courtney , Bryant Diane Pedrotty , Pfannenstiel Kathleen Hughes , Bryant Brian R.
Published: July 2015

Researchers design scripted supplemental mathematics programs for struggling students, such as students with learning disabilities (LD), to encourage an evidence-based presentation of concepts and use of instructional language in teachers’ implementation. In practice, teachers may or may not implement these programs with high fidelity, resulting in slight to substantial curriculum alterations. Yet there is a dearth of studies detailing the nature of changes teachers make during instruction or their perceptions of why the changes were necessary. We present a qualitative analysis of 10 special educators’ employment of a Base Ten Numeration and Multiplication/Division Strategies intervention with students with LD. Results show that teachers altered modeled practice and guided practice lesson components more than any other lesson component. Three interrelated themes illustrate reasons for pedagogy, materials, and tasks alterations: (a) scripted tasks/script, (b) connections, and (c) lesson delivery methods.
Polio-Like Illness Associated With Outbreak of Upper Respiratory Tract Infection in Children
Authors: Crone Megan , Tellier Raymond , Wei Xing-Chang , Kuhn Susan , Vanderkooi Otto G. , Kim Jong , Mah Jean K. , Mineyko Aleksandra
Published: July 2015

Poliomyelitis is a historically devastating neurological complication of poliovirus infection. Poliovirus vaccines have decreased the incidence of poliomyelitis to 209 global cases in 2014, with new cases of acute flaccid myelitis primarily associated with nonpolio enteroviruses. Recently, during outbreaks of enterovirus D68 throughout North America and Europe, cases of acute flaccid myelitis have been reported, suggesting another nonpolio enterovirus associated with acute flaccid myelitis. The authors describe 3 patients diagnosed with acute flaccid myelitis during a province-wide outbreak of enterovirus D68 with the virus detected in 2 of the patients. Given the significant morbidity associated with acute flaccid myelitis and potential for nonpolio enterovirus to cause outbreaks, prompt identification and notification of public health authorities are warranted.
Seizure Recurrence in Developmentally and Neurologically Normal Children With a Newly Diagnosed Unprovoked Seizure
Authors: Kim Hyunmi , Oh Ahyuda , de Grauw Xinyao , de Grauw Ton J.
Published: July 2015

This study aims to assess recurrence risk in developmentally and neurologically normal children with a newly diagnosed unprovoked seizure. The medical record was retrospectively reviewed in 393 children who had a newly diagnosed, unprovoked seizure. A total of 152 children met inclusion criteria. The relationship between seizure recurrence and variables was examined. Seventy cases had recurrent seizures. Total 113 cases had follow-up data and 70 cases of these (63.7%) experienced recurrent seizures. EEG was abnormal in 65 (44.8%): focal epileptiform abnormality in 34 cases (23.4%) and generalized epileptiform abnormality in 23 cases (15.9%). Brain MRI revealed any structural abnormality in 14 of 86 cases (16.3%). Neither EEG abnormality nor brain MRI abnormality was statistically significantly associated with increased seizure recurrence in this cohort. Further study is required to confirm the EEG and brain MRI findings in otherwise normal children with a newly diagnosed unprovoked seizure.
Gender, union leadership and collective bargaining: Brazil and South Africa
Authors: Ledwith Sue , Munakamwe Janet
Published: July 2015

Links between gender politics and leadership in trade unions and how these impact collective bargaining gender agendas are explored in this study of trade unionism in Brazil and South Africa. What the International Trade Union Confederation and others refer to as ‘unexplained’ gender pay gaps are discussed in relation to the absence of women in the collective bargaining process. This examination draws on research in both countries and concludes that gender leadership gaps and gender pay gaps are related.