bluuebunny/crossref_metadata_2025 huggingface dataset:
Predictors of use of dental care by children in north-central Appalachia in the USA
Authors: Nelson Cecelia I. , Wright Casey D. , Brumbaugh Jamey T. , Neiswanger Katherine , Crout Richard J. , Lilly Christa L. , Marazita Mary L. , McNeil Daniel W.
Published: July 2021

Use of dental services in childhood, especially preventive care, is associated with many important oral health outcomes throughout life. The Andersen behavioral model of healthcare utilization posits that predisposing characteristics, enabling resources, and need factors predict utilization in oral and other healthcare domains. Inequities that produce lower utilization of dental services in north-central Appalachia have been documented in comparison to the USA generally. Additionally, within Appalachia, there are disparities, such as those across different states related to varying public policies and resources supporting healthcare. Predictors of dental utilization in Appalachia have been a focus in adults, but less so in children. The aim of the current study was to understand predictors of dental utilization in children in north-central Appalachia in order to inform future research about how to intervene to address these disparities. In this study, there were 1,178 children, ages 1 through 10 years, from selected representative counties in West Virginia and Pennsylvania, along with a parent/caregiver, who were part of the Center for Oral Health Research in Appalachia (COHRA1) cohort. Use of dental services by their child was indicated by parents/caregivers, who also reported on sociodemographic, dental care-related anxiety and fear, and values and attitudes associated with oral healthcare. Results indicated that use of professional dental services by children was related to child age, dental anxiety and fear, and parental oral health values and attitudes. Older children in this age group, those who evidenced more dental care-related anxiety and fear, and whose parent/caregiver placed higher value on oral health and healthcare for themselves, were more likely to have had a dental visit in the past year.
Overload of anxiety on postural control impairments in chronic stroke survivors: The role of external focus and cognitive task on the automaticity of postural control
Authors: Ghorbanpour Zahra , Taghizadeh Ghorban , Hosseini Seyed Ali , Pishyareh Ebrahim , Ghomsheh Farhad Tabatabai , Bakhshi Enayatollah , Mehdizadeh Hajar
Published: July 2021

Background

Despite the high prevalence of anxiety among chronic stroke survivors and evidence of its negative effects on postural control in healthy subjects, it is unclear whether anxiety also affects postural control in these patients. Recent evidence of improved postural control of healthy subjects by distracting the attention using an external focus (EF) or cognitive task, raises the question of whether similar benefits would be observed in stroke survivors. Thus, the current study aimed to investigate the effects of anxiety and distracting the attention on postural control of chronic stroke survivors in terms of both postural sway measures and neuromuscular regulation.

Methods

Postural sway measures and ankle muscle activity of chronic stroke survivors with the high and low level of anxiety (HA-stroke (n = 17), and LA-stroke (n = 17), respectively) and age-, sex-, height-, and weight-matched healthy subjects (n = 17) were assessed while standing on rigid and foam surfaces under following conditions: baseline, internal focus (IF), EF, simple and hard cognitive tasks (SC and HC, respectively).

Results

Stroke survivors, particularly HA-stroke participants, showed greater postural sway measures (i.e. postural instability) and enhanced co-contraction of ankle muscles (i.e. stiffening of the neuromuscular system) compared with healthy subjects. As opposed to baseline and IF conditions, postural instability and neuromuscular stiffening significantly reduced in EF condition and decreased more in cognitive task conditions, particularly HC condition.

Conclusions

The results suggest that anxiety enhances stroke-induced postural instability promoting improper neuromuscular control of posture with stiffening strategy, which can be alleviated by EF and cognitive tasks.
Kinematic characteristics of the tennis serve from the ad and deuce court service positions in elite junior players
Authors: Fett Janina , Oberschelp Nils , Vuong Jo-Lâm , Wiewelhove Thimo , Ferrauti Alexander
Published: July 2021

Purpose

According to the official rules of the International Tennis Federation, players have to serve alternately from two different positions: the deuce (right, D) and the ad court (left, AD) side. This study aimed to compare body and ball kinematics of flat serves from both service sides.

Methods

In a controlled, semi-court laboratory setting, 14 elite male junior players served eight flat first serves to a target field directed to the receiver’s body from both service positions in a matched and counterbalanced order. An 8-camera-Vicon-System was used to capture the 3D-landmark trajectories.

Results

The mean service velocity was found to be similar on both sides (D: 151.4 ± 19.8 vs. AD: 150.5 ± 19.4 km/h), while multiple characteristics of the serve and ball kinematics differed significantly (p < .05). At starting, the front-foot angle relative to the baseline (D: 39.7±17.6° vs. AD: 31.1±17.4°) and lateral distance between the feet (D: 16.3 ± 12.9 cm vs. AD: 26.2 ± 11.9 cm) were significantly different. During the service, upper torso range of motion from maximum clockwise rotation until impact was significantly greater on the deuce court (D: 130.5 ± 19.8° vs. AD: 126.7 ± 21.1°). This was especially pronounced in foot-back technique players. Further, differences in the lateral ball impact location (D: 30.0 ± 24.1 cm vs. AD: 10.3 ± 23.3 cm) were observed.

Conclusions

Changing the service side affects the serve and ball kinematics in elite junior tennis players. Our results underline biomechanical differences regarding the starting position (feet and upper torso) as well as the movement and ball kinematics which could be relevant for skill acquisition, injury prevention and performance enhancement.
Research on efficiency measurement and spatiotemporal disparity of rural public health services in China
Authors: Li Liqing , Liu Zixuan
Published: July 2021

Objective

Based on the rural public health services of 29 regions in China, a service efficiency evaluation index system consisting of input and output dimensions was constructed, and the coupling, coordination and disparity efficiencies of rural public health services in China were studied, providing information to redress the imbalance in the interregional coordinated development.

Methods

The efficiency, spatiotemporal disparity pattern, spatial correlation and evolutionary trend of the coordinated development of rural public health services of 29 regions in China from 2004 to 2018 were analyzed using efficiency and spatial analysis methods such as Data Envelopment Analysis (DEA), kernel density estimation and Moran’s Ⅰ analysis.

Result

Nowadays, there are problems of unbalanced and insufficient development between the fields and regions in the development of rural public health services in China. The development level of rural public health services in various regions shows a distribution pattern that the service efficiency is “high in the middle”, “middle in the east” and “low in the west”, indicating a spatial cluster effect.
Surmising synchrony of sound and sight: Factors explaining variance of audiovisual integration in hurdling, tap dancing and drumming
Authors: Heins Nina , Pomp Jennifer , Kluger Daniel S. , Vinbrüx Stefan , Trempler Ima , Kohler Axel , Kornysheva Katja , Zentgraf Karen , Raab Markus , Schubotz Ricarda I.
Published: July 2021

Auditory and visual percepts are integrated even when they are not perfectly temporally aligned with each other, especially when the visual signal precedes the auditory signal. This window of temporal integration for asynchronous audiovisual stimuli is relatively well examined in the case of speech, while other natural action-induced sounds have been widely neglected. Here, we studied the detection of audiovisual asynchrony in three different whole-body actions with natural action-induced sounds–hurdling, tap dancing and drumming. In Study 1, we examined whether audiovisual asynchrony detection, assessed by a simultaneity judgment task, differs as a function of sound production intentionality. Based on previous findings, we expected that auditory and visual signals should be integrated over a wider temporal window for actions creating sounds intentionally (tap dancing), compared to actions creating sounds incidentally (hurdling). While percentages of perceived synchrony differed in the expected way, we identified two further factors, namely high event density and low rhythmicity, to induce higher synchrony ratings as well. Therefore, we systematically varied event density and rhythmicity in Study 2, this time using drumming stimuli to exert full control over these variables, and the same simultaneity judgment tasks. Results suggest that high event density leads to a bias to integrate rather than segregate auditory and visual signals, even at relatively large asynchronies. Rhythmicity had a similar, albeit weaker effect, when event density was low. Our findings demonstrate that shorter asynchronies and visual-first asynchronies lead to higher synchrony ratings of whole-body action, pointing to clear parallels with audiovisual integration in speech perception. Overconfidence in the naturally expected, that is, synchrony of sound and sight, was stronger for intentional (vs. incidental) sound production and for movements with high (vs. low) rhythmicity, presumably because both encourage predictive processes. In contrast, high event density appears to increase synchronicity judgments simply because it makes the detection of audiovisual asynchrony more difficult. More studies using real-life audiovisual stimuli with varying event densities and rhythmicities are needed to fully uncover the general mechanisms of audiovisual integration.
Clinical outcomes of adults hospitalized for laboratory confirmed respiratory syncytial virus or influenza virus infection
Authors: Chorazka Magdalena , Flury Domenica , Herzog Kathrin , Albrich Werner C. , Vuichard-Gysin Danielle
Published: July 2021

Objectives

Respiratory syncytial virus (RSV) can cause severe disease in adults, but far less is known than for influenza. The aim of our study was to compare the disease course of RSV infections with influenza infections among hospitalized adults.

Methods

We retrieved clinical data from an ongoing surveillance of adults hospitalized with RSV or influenza virus infection in two acute care hospitals in North-Eastern Switzerland during the winter seasons 2017/2018 and 2018/2019. Our main analysis compared the odds between RSV and influenza patients for admission to an intensive care unit (ICU) or in-hospital death within 7 days after admission.

Results

There were 548 patients, of whom 79 (14.4%) had an RSV and 469 (85.6%) an influenza virus infection. Both groups were similar with respect to age, sex, smoking status, nutritional state, and comorbidities. More RSV patients had an infiltrate on chest radiograph on admission (46.4% vs 29.9%, p = .007). The proportion of patients with RSV who died or were admitted to ICU within seven days after admission was 19.0% compared to 10.2% in influenza patients (p = .024). In multivariable analysis, a higher leukocyte count (adjusted OR 1.07, 95% CI 1.02–1.13, p = .013) and the presence of a pneumonic infiltrate (aOR 3.41, 95% CI 1.93–6.02) significantly increased the risk for experiencing the adverse primary outcome while the effect of the underlying viral pathogen became attenuated (aOR 1.18, 95% CI 0.58–2.41, p = .0.655).

Conclusions

Our results suggest that RSV is responsible for clinical courses at least as severe as influenza in adults. This supports the need for better guidance on diagnostic strategies as well as on preventive and therapeutic measures for hospitalized adults with RSV infection.
Negotiation of the use of medical contraception: Levers and obstacles within married couples in Benin
Authors: Aguessivognon Togla Aymard
Published: July 2021

In developing countries, millions of married women who want to use medical contraception are unable to do so for various reasons. To address this gap in access to contraception international development actors are emphasizing, among other things, the implementation of empowerment programs for women to enable them to take ownership of issues related to their sexual and reproductive health. Nevertheless, studies show that beyond their socio-demographic characteristics, negotiating contraception as a couple is the essential determinant of medical contraception usage among married women in developing countries. Thus, some authors suggest that this aspect be considered in the strategies of national family planning programs. However, we do not know much about the reasons underlying the negotiation or silence around contraception in Beninese married couples. To fill this gap, we conducted semi-structured interviews with women and men living as married couples in Benin. The results show that this type of negotiation is mainly influenced by specific factors that can act as levers or obstacles. These data could help family planning service providers in Benin and possibly other developing countries to ensure greater contraceptive use among married women.
Persistent homology as a new method of the assessment of heart rate variability
Authors: Graff Grzegorz , Graff Beata , Pilarczyk Paweł , Jabłoński Grzegorz , Gąsecki Dariusz , Narkiewicz Krzysztof
Published: July 2021

Heart rate variability (hrv) is a physiological phenomenon of the variation in the length of the time interval between consecutive heartbeats. In many cases it could be an indicator of the development of pathological states. The classical approach to the analysis of hrv includes time domain methods and frequency domain methods. However, attempts are still being made to define new and more effective hrv assessment tools. Persistent homology is a novel data analysis tool developed in the recent decades that is rooted at algebraic topology. The Topological Data Analysis (TDA) approach focuses on examining the shape of the data in terms of connectedness and holes, and has recently proved to be very effective in various fields of research. In this paper we propose the use of persistent homology to the hrv analysis. We recall selected topological descriptors used in the literature and we introduce some new topological descriptors that reflect the specificity of hrv, and we discuss their relation to the standard hrv measures. In particular, we show that this novel approach provides a collection of indices that might be at least as useful as the classical parameters in differentiating between series of beat-to-beat intervals (RR-intervals) in healthy subjects and patients suffering from a stroke episode.
Prioritization of neglected tropical zoonotic diseases: A one health perspective from Tigray region, Northern Ethiopia
Authors: Mersha Tadesse Teferi , Mekonnen Wolde Biruk , Shumuye Nigus Abebe , Hailu Abrha Bsrat , Mohammed Abrahim Hassen , Redda Yisehak Tsegaye , Abera Birhanu Hadush , Menghistu Habtamu Taddele
Published: July 2021

Neglected tropical zoonotic diseases (NTZDs) continue to have a major effect on the health of humans and animals. In this study, a one health approach was used to prioritize and rank neglected tropical zoonotic diseases at the regional and zonal levels in Tigray National Regional State, Ethiopia. For prioritization of NTZDs a cross-sectional study through a structured questionnaire was administered to 313 health experts from human and animal health sectors. In addition, focus group discussions (FGD) were held with purposively selected key informants. Descriptive, and Multivariable analysis was applied to report the results and a ranked list of diseases was developed at the zonal and regional level. In the region, 8 of the 12 World Health Organization listed NTZDs were considered major diseases including anthrax, brucellosis, bovine tuberculosis, taeniasis, leishmaniasis, rabies, schistosomiasis, and soil-transmitted helminths. Considering the zoonotic and socioeconomic importance of the diseases at the regional level, rabies ranked 1stwhereas anthrax, bovine tuberculosis, leishmaniasis, and brucellosis were ranked from 2nd to 5th, respectively. The FGD result also supported the prioritization result. The Multivariable analysis showed a statistically significant difference in the zonal distribution of anthrax (р = 0.009, OR = 1.16), taeniasis (p<0.001, OR = 0.82), leishmaniasis (p<0.001, OR = 1.91), rabies (p = 0.020, OR = 0.79) and soil-transmitted helminths (p = 0.007, OR = 0.87) but not for brucellosis (p = 0.585), bovine tuberculosis (p = 0.505), and schistosomiasis (p = 0.421). Anthrax (p<0.001, OR = 26.68), brucellosis (p<0.001, OR = 13.18), and taeniasis (p<0.001, OR = 6.17) were considered as the major zoonotic diseases by veterinary practitioners than human health practitioners whereas, leishmaniasis was recognized as a major health challenge by human health professionals. Understanding the priority diseases in the region is supportive for informed decision-making and prioritizes the limited resources to use. Furthermore, strengthening the collaboration between human and animal health professions is important to control the diseases.
A simple parametric representation of the Hodgkin-Huxley model
Authors: Rodríguez-Collado Alejandro , Rueda Cristina
Published: July 2021

The Hodgkin-Huxley model, decades after its first presentation, is still a reference model in neuroscience as it has successfully reproduced the electrophysiological activity of many organisms. The primary signal in the model represents the membrane potential of a neuron. A simple representation of this signal is presented in this paper. The new proposal is an adapted Frequency Modulated Möbius multicomponent model defined as a signal plus error model in which the signal is decomposed as a sum of waves. The main strengths of the method are the simple parametric formulation, the interpretability and flexibility of the parameters that describe and discriminate the waveforms, the estimators’ identifiability and accuracy, and the robustness against noise. The approach is validated with a broad simulation experiment of Hodgkin-Huxley signals and real data from squid giant axons. Interesting differences between simulated and real data emerge from the comparison of the parameter configurations. Furthermore, the potential of the FMM parameters to predict Hodgkin-Huxley model parameters is shown using different Machine Learning methods. Finally, promising contributions of the approach in Spike Sorting and cell-type classification are detailed.
In vivo recellularization of xenogeneic vascular grafts decellularized with high hydrostatic pressure method in a porcine carotid arterial interpose model
Authors: Kurokawa Shunji , Hashimoto Yoshihide , Funamoto Seiichi , Murata Kozue , Yamashita Akitatsu , Yamazaki Kazuhiro , Ikeda Tadashi , Minatoya Kenji , Kishida Akio , Masumoto Hidetoshi
Published: July 2021

Autologous vascular grafts are widely used in revascularization surgeries for small caliber targets. However, the availability of autologous conduits might be limited due to prior surgeries or the quality of vessels. Xenogeneic decellularized vascular grafts from animals can potentially be a substitute of autologous vascular grafts. Decellularization with high hydrostatic pressure (HHP) is reported to highly preserve extracellular matrix (ECM), creating feasible conditions for recellularization and vascular remodeling after implantation. In the present study, we conducted xenogeneic implantation of HHP-decellularized bovine vascular grafts from dorsalis pedis arteries to porcine carotid arteries and posteriorly evaluated graft patency, ECM preservation and recellularization. Avoiding damage of the luminal surface of the grafts from drying significantly during the surgical procedure increased the graft patency at 4 weeks after implantation (P = 0.0079). After the technical improvement, all grafts (N = 5) were patent with mild stenosis due to intimal hyperplasia at 4 weeks after implantation. Neither aneurysmal change nor massive thrombosis was observed, even without administration of anticoagulants nor anti-platelet agents. Elastica van Gieson and Sirius-red stainings revealed fair preservation of ECM proteins including elastin and collagen after implantation. The luminal surface of the grafts were thoroughly covered with von Willebrand factor-positive endothelium. Scanning electron microscopy of the luminal surface of implanted grafts exhibited a cobblestone-like endothelial cell layer which is similar to native vascular endothelium. Recellularization of the tunica media with alpha-smooth muscle actin-positive smooth muscle cells was partly observed. Thus, we confirmed that HHP-decellularized grafts are feasible for xenogeneic implantation accompanied by recellularization by recipient cells.
A mixed-methods evaluation of the uptake of novel differentiated ART delivery models in a national sample of health facilities in Uganda
Authors: Zakumumpa Henry , Makobu Kimani , Ntawiha Wilbrod , Maniple Everd
Published: July 2021

Introduction

Since 2017, Uganda has been implementing five differentiated antiretroviral therapy (ART) delivery models to improve the quality of HIV care and to achieve health-system efficiencies. Community-based models include Community Client-Led ART Delivery and Community Drug Distribution Points. Facility-based models include Fast Track Drug Refill, Facility Based Group and Facility Based Individual Management. We set out to assess the extent of uptake of these ART delivery models and to describe barriers to uptake of either facility-based or community-based models.

Methods

Between December 2019 and February 2020, we conducted a mixed-methods study entailing a cross-sectional health facility survey (n = 116) and in-depth interviews (n = 16) with ART clinic managers in ten case-study facilities as well as six focus group discussions (56 participants) with patients enrolled in differentiated ART models. Facilities were selected based on the 10 geographic sub-regions of Uganda. Statistical analyses were performed in STATA (v13) while qualitative data were analysed by thematic approach.

Results

Most facilities 63 (57%) commenced implementation of differentiated ART delivery in 2018. Fast Track Drug Delivery was the most common facility-based model (implemented in 100 or 86% of health facilities). Community Client-Led ART Delivery was the most popular community model (63/116 or 54%). Community Drug Distribution Points had the lowest uptake with only 33 (24.88%) facilities implementing them. By ownership-type, for-profit facilities reported the lowest uptake of differentiated ART models. Barriers to enrolment in community-based models include HIV-related stigma and low enrolment of adult males in community models.

Conclusion

To the best of our knowledge this is the first study reporting national coverage of differentiated ART delivery models in Uganda. Overall, there has been a higher uptake of facility-based models. Interventions for enhancing the uptake of differentiated ART models in for-profit facilities are recommended.
Pressure measurement in the reticulum to detect different behaviors of healthy cows
Authors: Scheurwater Josje , Hostens Miel , Nielen Mirjam , Heesterbeek Hans , Schot Arend , van Hoeij Rob , Aardema Hilde
Published: July 2021

The aim of the current study was to investigate the relation between reticulorumen contractions and monitored cow behaviors. A purpose-built pressure measuring device was used and shown to be capable of detecting the known contraction patterns in the reticulorumen of four rumen-fistulated cows. Reticular pressure data was used to build a random forest algorithm, a learning algorithm based on a combination of decision trees, to detect rumination and other cow behaviors. In addition, we developed a peak-detection algorithm for rumination based on visual inspection of patterns in reticular pressure. Cow behaviors, differentiated in ruminating, eating, drinking, sleeping and ‘other’, as scored from video observation, were used to develop and test the algorithms. The results demonstrated that rumination of a cow can be detected by measuring pressure differences in the reticulum using either the random forest algorithm or the peak-detection algorithm. The random forest algorithm showed very robust performances for detecting rumination with an accuracy of 0.98, a sensitivity of 0.95 and a specificity of 0.99. The peak-detection algorithm could detect rumination robustly, with an accuracy of 0.92, a sensitivity of 0.97 and a specificity of 0.90. In addition, we provide proof of principle that a random forest algorithm can also detect eating, drinking and sleeping behavior from the same data with performances above 0.90 for all measures. The measurement device used in this study needed rumen-fistulated cows, but the results indicate that behavior detection using algorithms based on only measurements in the reticulum is feasible. This is promising as it may allow future wireless sensor techniques in the reticulum to continuously monitor a range of important behaviors of cows.
A quasi-experimental study of ethnic and gender bias in university grading
Authors: Bischoff Carina Saxlund , Ejrnæs Anders , Rubin Olivier
Published: July 2021

This paper contributes to the debate on race- and gender-based discrimination in grading. We apply a quasi-experimental research design exploiting a shift from open grading in 2018 (examinee’s name clearly visible on written assignments), to blind grading in 2019 (only student ID number visible). The analysis thus informs name-based stereotyping and discrimination, where student ethnicity and gender are derived from their names on written assignments. The case is a quantitative methods exam at Roskilde University (Denmark). We rely on OLS regression models with interaction terms to analyze whether blind grading has any impact on the relative grading differences between the sexes (female vs. male examinees) and/or between the two core ethnic groups (ethnic minorities vs. ethnic majority examinees). The results show no evidence of gender or ethnic bias based on names in the grading process. The results were validated by several checks for robustness. We argue that the weaker evidence of ethnic discrimination in grading vis-à-vis discrimination in employment and housing suggests the relevance of gauging the stakes involved in potentially discriminatory activities.
Population-based utility scores for HPV infection and cervical squamous cell carcinoma among Australian Indigenous women
Authors: Ju Xiangqun , Canfell Karen , Howard Kirsten , Garvey Gail , Hedges Joanne , Smith Megan , Jamieson Lisa
Published: July 2021

Objective

Working in partnership with Indigenous communities in South Australia, we aimed to develop, pilot test and estimate utility scores for health states relating to cervical cancer screening, precancer, and invasive cervical cancer and precancer/cancer treatment among Indigenous women.

Methods

Development and pilot testing of hypothetical cervical cancer health states, specifically through the lens of being an Indigenous Australian woman, was done with an Indigenous Reference Group in conjunction with five female Indigenous community members. Six health states were developed. These included: (1) Screened: cytology normal; (2) human papillomaviruses (HPV) positive with cytology normal; (3) low grade cytology (LSIL);(4) high grade cytology (HSIL); (5) early stage cervical cancer and; (6) later stage cervical cancer. Utility scores were calculated using a two-stage standard gamble approach among a large cohort of Indigenous Australian women taking part in a broader study involving oral HPV infection. The mean and standard deviation (SD) of the rank, percentage of respondents with a utility = 1 (perfect health) and utility score of each health state was summarised. Mean (SD) and medians and inter-quartile range (IQR) over 12 months and lifetime duration were calculated. Potential differences by age and residential location were assessed using the Wilcox Sum Rank test.

Results

Data was obtained from 513 Indigenous women aged 19+ years. Mean utility scores were higher for the four non-cancer health states than for invasive cervical cancer states (p-values <0.05). Lower mean utility scores were observed for late stage cervical cancer, with 0.69 at 12 months and 0.70 for lifetime duration (Intra-class correlation coefficients = 0.425). Higher utility scores were observed for the four non-cancer health states among non-metropolitan participants (ranged from 0.93 to 0.98) compared with metropolitan participants (ranged from 0.86 to 0.93) (p-values<0.05).

Conclusion

Among a large cohort of Indigenous Australian women, the reduction in quality of life (which utilities reflect) was perceived to be greater with increasing severity of cervical cancer health states. There were differences observed by geographic location, with positive cervical screening and precursor cancer-related quality of life being much higher among non-metropolitan-dwelling participants. These utility values, from one of the largest such studies ever performed in any population will be uniquely able to inform modelled evaluations of the benefits and costs of cervical cancer prevention interventions in Indigenous women.
Association of GSTP1 Ile105Val polymorphism with the risk of coronary heart disease: An updated meta-analysis
Authors: Song Yadong , Liu Xiaoli , Luo Cheng , Chen Liangkai , Gong Lin , Yu Hanbin , Wang Bin , Liu Ernan , Xu Huiqiong , Liang Jiansheng
Published: July 2021

Background

Numerous case-control studies have investigated the association between GSTP1 Ile105Val polymorphism and CHD risk, but the results from published studies were inconclusive. The present meta-analysis was performed to derive a more precise estimation.

Methods

PubMed, EMBASE, and Web of Science database searches were conducted to retrieve relevant articles.

Results

Ultimately, 5,451 CHD cases and 5,561 controls from 15 studies were included. Pooled analysis did not yield any statistically significant association between GSTP1 Ile105Val polymorphism and CHD risk for the overall population (Val vs. Ile: OR, 1.05; 95% CI, 0.93 to 1.18; Val/Val vs. Ile/Ile: OR, 1.09; 95% CI, 0.83 to 1.42; Val/Ile vs. Ile/Ile: OR, 1.09; 95% CI, 0.93 to 1.28; Val/Val vs. Val/Ile+Ile/Ile: OR, 1.04; 95% CI, 0.83 to 1.30; Val/Val+Val/Ile vs. Ile/Ile: OR, 1.14; 95% CI, 0.97 to 1.33). Subgroup analyses and sensitivity analyses indicated that GSTP1 Ile105Val polymorphism was still not associated with an increased risk of CHD. After excluding studies detected by Galbraith plots as major sources of heterogeneity, these relationships were still not significant.

Conclusions

The overall results did not reveal a major role of the GSTP1 Ile105Val polymorphism in modulating CHD risk. Well-designed studies with large sample sizes are needed to validate our findings and explore the possible gene-gene or gene-environment interactions.
Habitat selection by wolves and mountain lions during summer in western Montana
Authors: Peterson Collin J. , Mitchell Michael S. , DeCesare Nicholas J. , Bishop Chad J. , Sells Sarah S.
Published: July 2021

In the Northern Rockies of the United States, predators like wolves (Canis lupus) and mountain lions (Puma concolor) have been implicated in fluctuations or declines in populations of game species like elk (Cervus canadensis) and mule deer (Odocoileus hemionus). In particular, local distributions of these predators may affect ungulate behavior, use of space, and dynamics. Our goal was to develop generalizable predictions of habitat selection by wolves and mountain lions across western Montana. We hypothesized both predator species would select habitat that maximized their chances of encountering and killing ungulates and that minimized their chances of encountering humans. We assessed habitat selection by these predators during summer using within-home range (3rdorder) resource selection functions (RSFs) in multiple study areas throughout western Montana, and tested how generalizable RSF predictions were by applying them to out-of-sample telemetry data from separate study areas. Selection for vegetation cover-types varied substantially among wolves in different study areas. Nonetheless, our predictions of 3rdorder selection by wolves were highly generalizable across different study areas. Wolves consistently selected simple topography where ungulate prey may be more susceptible to their cursorial hunting mode. Topographic features may serve as better proxies of predation risk by wolves than vegetation cover-types. Predictions of mountain lion distribution were less generalizable. Use of rugged terrain by mountain lions varied across ecosystem-types, likely because mountain lions targeted the habitats of different prey species in each study area. Our findings suggest that features that facilitate the hunting mode of a predator (i.e. simple topography for cursorial predators and hiding cover for stalking predators) may be more generalizable predictors of their habitat selection than features associated with local prey densities.
Maternal and neonatal canine cortisol measurement in multiple matrices during the perinatal period: A pilot study
Authors: Groppetti Debora , Meazzi Sara , Filipe Joel F. S. , Colombani Carla , Panseri Sara , Zanzani Sergio A. , Palestrini Clara , Cannas Simona , Giordano Alessia , Pecile Alessandro
Published: July 2021

Stress exposure during perinatal period may lead to maternal cortisol increase that negatively affects the offspring development. In recent years, the interest on non-invasive sampling methods to measure cortisol as a marker of stress is increasing in both humans and animals. Indeed, discomfort due to blood collection may compromise the diagnostic outcome, mainly in uncooperative patients. So far, some alternative matrices but not milk have been explored in adult dogs, while no data are available on the neonate and paediatric live pups. This study aimed to measure cortisol concentration in different biological substrates in both dams (blood, saliva, hair and milk) and pups (saliva and hair) at established times from proestrus up to two months after parturition. For this purpose, five female German shepherd bitches and their 22 pups were enrolled. Cortisol concentration was assessed using the enzyme immunoassay kit (Salivary Cortisol ELISA kit, Salimetrics) after matrices appropriate preparation if required. Cortisol was measurable in all the substrates, except some milk samples below the detection limit. Maternal cortisol concentrations differed among the matrices (P<0.0001) with the highest values recorded in plasma (median 0.596 μg/dL) compared to saliva (median 0.159 μg/dL), hair (median 0.083 μg/dL) and milk (median 0.045 μg/dL). Cortisol in dams did not vary within the same matrix over time. In pups, salivary (median 0.295 μg/dL) cortisol was always higher than hair (median 0.049 μg/dL;P<0.0001). At birth (P= 0.01) and two months later (P= 0.05), neonatal salivary cortisol was higher compared to other samplings. The present study demonstrates the suitability of these innovative substrates for cortisol measurement, suggesting them as potential diagnostic support in canine neonatology and welfare.
Ward-level factors associated with methicillin-resistant Staphylococcus aureus acquisition–an electronic medical records study in Singapore
Authors: Tun Zaw Myo , Fisher Dale A. , Salmon Sharon , Tam Clarence C.
Published: July 2021

Background

Methicillin-ResistantStaphylococcus aureus(MRSA) is endemic in hospitals worldwide. Intrahospital transfers may impact MRSA acquisition risk experienced by patients. In this study, we investigated ward characteristics and connectivity that are associated with MRSA acquisition.

Methods

We analysed electronic medical records on patient transfers and MRSA screening of in-patients at an acute-care tertiary hospital in Singapore to investigate whether ward characteristics and connectivity within a network of in-patient wards were associated with MRSA acquisition rates over a period of four years.

Results

Most patient transfers concentrated in a stable core network of wards. Factors associated with increased rate of MRSA acquisition were MRSA prevalence among patients transferred from other wards (rate ratio (RR): 7.74 [95% confidence interval (CI): 3.88, 15.44], additional 5 percentage point), critical care ward (RR: 1.72 [95% CI: 1.09, 2.70]) and presence of MRSA cohorting beds (RR: 1.39 [95% CI: 1.03, 1.90]. Oncology ward (RR: 0.66 [95% CI: 0.46, 0.94]) (compared to medical ward), and median length of stay (RR: 0.70 [95% CI: 0.55, 0.90], additional 1.5 days) were associated with lower acquisition rates. In addition, we found evidence of interaction between MRSA prevalence among patients transferred from other wards and weighted in-degree although the latter was not associated with MRSA acquisition after controlling for confounders.

Conclusion

Wards with higher MRSA prevalence among patients transferred from other wards were more likely to have higher MRSA acquisition rate. Its effect further increased in wards receiving greater number of patients. In addition, critical care ward, presence of MRSA cohorting beds, ward specialty, and median length of stay were associated with MRSA acquisition.
Geographical variations in maternal dietary patterns during pregnancy associated with birth weight in Shaanxi province, Northwestern China
Authors: Liu Yini , Zhang Huihui , Zhao Yaling , Chen Fangyao , Mi Baibing , Zhou Jing , Chen Yulong , Wang Duolao , Pei Leilei
Published: July 2021

The geographical variation of maternal dietary patterns related to birth outcomes is important for improving the health of mothers and children; however, it is currently unknown. Thus, the objective of the study was to investigate geographical variations of maternal dietary pattern during pregnancy, and evaluate the spatial varying association of maternal dietary patterns in pregnancy with abnormal birth weight. A population-based cross-sectional study was conducted in Shaanxi province in Northwest China in 2013 to evaluate the relationship between abnormal birth weight and dietary pattern using the Geographically Weighted Logistic Regression (GWLR). Three dietary patterns during pregnancy were extracted through factor analysis, explaining approximately 45.8% of the variability of food intake. Approximately 81.6% of mothers with higher scores on the equilibrium pattern was more unlikely to have small for gestational age (SGA) infants, with the lower OR observed in Central and South Shaanxi. The snacks pattern was positively associated with low birth weight (LBW) for 23.2% of participants, with the highest OR in Central Shaanxi. Among about 80.0% of participants with higher scores on the snacks pattern living in South and Central Shaanxi, there was a higher risk for SGA. The OR values tend to descend from South to North Shaanxi. The OR values of the negative association between prudent pattern and LBW decreased from South to North Shaanxi among approximately 59.3% of participants. The prudent pattern was also negatively associated with the increasing risk of fetal macrosomia among 19.2% of participants living mainly in South Shaanxi. The association of maternal dietary patterns during pregnancy with abnormal birth weight varied geographically across Shaanxi province. The findings emphasize the importance of geographical distribution to improve the dietary patterns among disadvantaged pregnant women.
Cefaclor-induced hypersensitivity: Differences in the incidence of anaphylaxis relative to other 2nd and 3rd generation cephalosporins
Authors: Rhyou Hyo-In , Nam Young-Hee , Kim Su-Chin , Doo Go-Eun , Ha Chae-Yeon , Nam Hee-Joo , Woo Sung-Dae , Lee Youngsoo , Jang Jae-Hyuk , Lee Hyun-Young , Ye Young-Min
Published: July 2021

Cefaclor, a second-generation oral cephalosporin, is the most frequently prescribed cephalosporin in Korea. Studies, however, have yet to analyze the incidence of cefaclor-associated adverse drug reactions (ADRs), including hypersensitivity (HS), according to total national usage rates. This study aimed to investigate the incidence rates and clinical features of cefaclor ADRs reported to the Korean Adverse Event Reporting System (KAERS) and Health Insurance Review and Assessment Service (HIRA) database for the most recent 5 years. Reviewing the HIRA database, which contains information on all insurance claims, including prescribed medications and patient demographics, we identified the total number of individuals who had been prescribed cefaclor and other cephalosporins including 2nd generation without cefaclor and 3rd generation antibiotics from January 2014 to December 2018. Additionally, we retrospectively analyzed all ADRs reported to the KAERS for these drugs over the same study period. Incidence rates for ADRs, HS, and anaphylaxis to cefaclor were 1.92/10,000 persons, 1.17/10,000 persons, and 0.38/10,000 persons, respectively, lower than those to other 2nd and 3rd cephalosporins. Among all ADRs, HS (60.9% vs. 43.6% vs. 44.8%, P <0.001) and anaphylaxis (19.8% vs. 4.6% vs. 4.7%, P <0.001) were more common for cefaclor than for other 2nd and 3rd cephalosporins. Females, individuals under 65 years of age, concomitant use of drugs, and serious ADRs were more strongly associated with HS to cefaclor than with HS to other 2nd and 3rd cephalosporins. In a nationwide database for the Korean population, the incidence of cefaclor-induced ADRs, particularly HS and anaphylaxis, was high. Female sex, age younger than 65 years, and concomitant use of drugs may be associated with HS to cefaclor.
Association between antenatal corticosteroid use and perinatal mortality among preterm births in hospitals in Tanzania
Authors: Mwita Stanley , Konje Eveline , Kamala Benjamin , Izina Angelina , Kilonzo Semvua , Kigombola Andrew , Marwa Karol J. , Jande Mary , Dewey Deborah
Published: July 2021

Objectives

The primary aims of this study were to investigate if exposure to antenatal corticosteroids (ACS) was associated with lower rates of perinatal mortality (primary outcome) and other adverse perinatal outcomes (i.e., stillbirth, early neonatal mortality, APGAR score of < 7 at 5 mins, neonatal sepsis and respiratory distress syndrome) in preterm infants in hospitals in Tanzania. We also examine factors associated with administration of ACS among women at risk of preterm delivery.

Methods

A hospital-based prospective chart review study was undertaken in four hospitals located in Nyamagana and Sengerema districts, Tanzania. The study population included all stillborn and live born preterm infants delivered between 24 to 34 weeks of gestation between July 2019 to February 2020. A total 1125 preterm infants were delivered by 1008 women (895 singletons, 230 multiple). Sociodemographic and medical data were recorded from participants’ medical records.

Results

Three hundred and fifty-six (35.3%) women were administered at least one dose of ACS between 24 to 34 weeks’ gestation and 385 (34.2%) infants were exposed to ACS. Infants exposed to ACS had a lower rate of perinatal mortality (13.77%) compared to those who were not exposed (28.38%). Multivariate analysis indicated that infants exposed to ACS were less likely to die during perinatal period, aRR 0.34 (95%CI 0.26-0.44). Only one-third of the sample was provided with ACS. Administration of ACS was associated with maternal education, attending antenatal care more than 3 times, method used to assess gestational age, maternal infection, exposure to maternal antibiotics, delivery mode and level of health facility.

Conclusion

ACS significantly reduced the risk in perinatal mortality among infants born preterm in a limited resource setting. However, only about one-third of eligible women were provided with ACS, indicating low usage of ACS. Numerous factors were associated with low usage of ACS in this setting.
Impact of microRNA-210 on wound healing among the patients with diabetic foot ulcer
Authors: Pichu Sivakamasundari , Vimalraj Selvaraj , Viswanathan Vijay
Published: July 2021

Aim

Diabetic foot ulcer (DFU) is a major concern in diabetes and its control requires in-depth molecular investigation. The present study aimed to screen the expression of microRNA-210 (miR-210) and its association in hypoxic pathway in DFU patients.

Methods

The study consists of 3 groups of circulation samples (50 in each group of: healthy volunteers, T2DM and T2DM with DFU) and 2 groups of tissue samples (10 in each group of: control and T2DM with DFU). Expression of miR-210 and hypoxia inducible factor-1 alpha (HIF-1α), and its responsive genes such as VEGF, TNF-α, IL-6, BCl2, Bax and Caspase 3 were analyzed by RT-PCR, Western blot and ELISA analyses.

Results

The HIF-1α expression decreased in DFU patients with increased miR-210 expression in both circulation and tissue biopsies. The circulatory IL-6 and inflammatory gene TNF-α expression was increased in DFU compared to healthy controls and T2DM subjects. Further, we found there was no alteration in the angiogenic marker, VEGF expression. In comparison, anti-apoptotic BCl2 was decreased and Bax and Caspase 3 was increased in DFU tissues relative to control.

Conclusions

The study showed that there was an inverse relationship between miR-210 and HIF-1α expression in patients with DFU, indicating that miR-210 may regulate the expression of the hypoxic gene.
A face recognition software framework based on principal component analysis
Authors: Peng Peng , Portugal Ivens , Alencar Paulo , Cowan Donald
Published: July 2021

Face recognition, as one of the major biometrics identification methods, has been applied in different fields involving economics, military, e-commerce, and security. Its touchless identification process and non-compulsory rule to users are irreplaceable by other approaches, such as iris recognition or fingerprint recognition. Among all face recognition techniques, principal component analysis (PCA), proposed in the earliest stage, still attracts researchers because of its property of reducing data dimensionality without losing important information. Nevertheless, establishing a PCA-based face recognition system is still time-consuming, since there are different problems that need to be considered in practical applications, such as illumination, facial expression, or shooting angle. Furthermore, it still costs a lot of effort for software developers to integrate toolkit implementations in applications. This paper provides a software framework for PCA-based face recognition aimed at assisting software developers to customize their applications efficiently. The framework describes the complete process of PCA-based face recognition, and in each step, multiple variations are offered for different requirements. Some of the variations in the same step can work collaboratively and some steps can be omitted in specific situations; thus, the total number of variations exceeds 150. The implementation of all approaches presented in the framework is provided.