bluuebunny/crossref_metadata_2025 huggingface dataset:
Implimentasi Reliability Centered Maintenance Untuk Mengurangi Downtime Mesin Pada Perusahaan Manufaktur Kertas Dengan Metode Failure Mode And Effect Analysis
Authors: Kurniawan Muhammad Helmi , Khusnul Khotimah Ayuningtiyas
Published: November 2023

PT. XXX merupakan salah satu perusahaan manufaktur yang memproduksi kertas dan hasil-hasil produksi kertas terbesar di indonesia yang terintegrasi secara vertikal. Dalam penelitian ini, akar permasalahan terhadap rendahnya produktifitas penurunan tekanan pada bagian press cylinder wire machine akan diidentifikas, FMEA akan dipakai untuk menentukan tingkat permasalahan yang menghambat produktifitas press cylinder wire machine. Metode penelitian yang dilaksanakan, menggunakan metode eksperimen. Langkah awal untuk melakukan perancangan RCM adalah mengetahui mesin yang sering mengalami kegagalan yang didapatkan dengan wawancara pihak perusahaan. Mesin tersebut adalah mesin press part, mesin size press, mesin driyer merupakan mesin yang tercatat sebagai mesin yang sering bermasalah.  Mesin  beserta  komponennya  tersebut  akan  dilakukan  perencanaan pemeliharan menggunakan reliability centered maintenance (RCM).  Identifikasi setiap kesalahan dan akar penyebab setiap kesalahan keluar dari setiap bagian mesin. Setelah analisis yang cermat dari semua bagian rakitan piston, ditentukan bahwa sebagian besar kegagalan yang ditemui disebabkan oleh penyebab yang tidak disengaja dan tegangan berlebih, kecuali semua seal dan ring piston. Berdasarkan pemilihan material, desain ulang pelat dorong dudukan jari diusulkan karena perluasan baut jari dorong yang berlebihan disebabkan oleh kelonggaran dan ketidaksejajaran.
Penggunaan Tepung Blondo dan Anuwun sebagai Substitusi Tepung Terigu terhadap Mutu Produk Suplementasi Gizi Berbentuk Cookies
Authors: Sjarif Sjamsiwarni R. , Mandei Judith H. , Edam Mariati , Kumolontang Nova P. , Nuryadi Alim M. , Manurung Supardi , Apriyani Shinta W. , Assah Yunita F.
Published: November 2023

Penelitian bertujuan untuk mengetahui kandungan gizi tepung blondo dan anuwun dan untuk mengetahui pengaruh penggunaan tepung blondo dan tepung anuwun sebagai bahan substitusi tepung terigu dalam menghasilkan cookies sebagai produk suplementasi gizi. Pembuatan cookies menggunakan perlakuan komposisi tepung terigu : tepung anuwun : tepung blondo, dengan K0 = Kontrol, K1 = 50:25:25, K2 = 50:30:20, K3 = 50:35:15 dan K4 = 50:40:10. Pengujian dilakukan terhadap kandungan gizi tepung blondo dan anuwun, penerimaan organoleptik produk cookies, dan untuk analisis mutu produk cookies. Hasil penelitian menunjukkan bahwa tepung blondo dan tepung anuwun mengandung air, abu, protein, lemak, pati, sukrosa, serat pangan, Na, Ca, P, Zn, dan Fe. Hasil uji organoleptik menunjukkan panelis menyukai warna, bau, dan tekstur cookies, namun tidak menyukai rasa cookies dengan perlakuan K4 = 50:40:10. Perlakuan mempengaruhi kesukaan panelis secara organoleptik. Perlakuan terbaik adalah perlakuan K1 (50:25:25) di mana produk ini disukai panelis, baik warna, tekstur, bau, dan rasa cookies. Hasil uji kualitas produk cookies, beberapa mineral (Fe, Ca, Zn) dan vitamin E, belum memenuhi syarat mutu produk suplementasi gizi anak SD kategori kurus.
Analisis Komposisi Gel coat Terhadap Penyerapan Air dan Kekuatan Tarik pada Komposit Serat Gelas/Poliester
Authors: Ahmad  , Hastuti A. Widya
Published: November 2023

Artikel ini menganalisis pengaruh komposisi gel coat terhadap kekutan tarik komposit serat gelas/poliester sebelum direndam dan setelah direndam didalam air laut dan air sungai. Metode yang digunakan adalah dengan jalan merendam spesimen komposit selama 1 sampai 6 bulan kemudian dilakukan pengujian tarik dan pengujian penyerapan. Hasilnya dibandingkan antara komposisi Gel coat kode K1, K2, K3,K4 dan K5. Hasil analisis didapatkan bahwa kekuatan tarik yang paling baik adalah kekuatan tarik dengan komposisi gel coat 0.3 kg Reolosil QS-102 dengan 10 kg Resin SHCP 268BQTN (K2) dengan nilai kekuatan tarik sebesar 51.9931 MPa setelah direndam selama 6 bulan dari sebelum direndam yaitu 78.0919 MPa turun sekitar 33.4206% dibandingkan komposisi lain yang turun sampai 46.3401% (K3). Untuk melihat pengaruh permukaan komposit sebelum dan setelah direndam dilakukan pengujian SEM.
Analisis Pengendalian Kualitas Pada Proses Produksi Bandung Dinning Table (Studi Kasus CV. ABC) dengan Metode Statistik
Authors: Purwanto Agung Ari , Isnaili Sheila
Published: November 2023

Proses produksi suatu produk dapat dikendalikan kualitasnya dengan menganalisis alur proses maupun produk cacat yang terdapat pada proses produksinya. Masalah cacat produk yang sering timbul pada proses produksi Bandung Dinning Table pada CV.ABC Furnitur  yaitu timbulnya bercak hitam, goresan, terdapat lubang dan permukaan yang masih kasar pada top table, proses pemantauan kesalahan/cacat pada suatu produk dilaksanankan secara kontinyu untuk dapat menjaga kualistas produk. Metode yang digunakan adalah metode statistik, diantaranya check sheet, Histogram, Diagram pareto, Diagram Sebab-Akibat, Peta Kendali, dan FMAE. Hasil dari check sheet rata-rata produk cacat yang dihasilkan 12,56% dari rata-rata jumlah produk yang di produksi, Histogram cacat produk menyebutkan jumlah cacat permukaan sebesar 144 unit produk, hasil dari control chart tidak terdapat titik berada diluar batas kendali atas dan bawah, untuk hasil analisis FMEA di dapatkan SDM menjadi factor penyebab masalah dengan nilai severity 8 (High), Occurance 8 (High) dan detection 6 (Rendah).
Perancangan Fasilitas Kerja Ergonomis pada Proses Penggilingan Adonan di IKM Melati Rosmah Kabupaten Sinjai
Authors: Ramadhan Della Ginza , Sawal Ahmad , Damayanti Putri
Published: November 2023

IKM Melati Rosmah merupakan salah satu IKM yang memproduksi jajanan tradisional khas Sinjai berupa kue simpul atau disebut juga dengan poto-poto yang seluruh proses produksinya dilakukan secara manual. Proses produksinya tidak memperhatikan kaidah ergonomi terutama pada bagian penggilingan yang berpotensi menyebabkan gangguan kesehatan kerja. Keluhan yang dirasakan pekerja antara lain rasa nyeri dan sakit di beberapa bagian tubuh seperti leher, pinggang, punggung, tangan, dan lutut. Dari permasalahan tersebut maka perlu dilakukan identifikasi nilai postur kerja dan perancangan fasilitas kerja yang ergonomis pada proses penggilingan pembuatan kue simpul. Pada penelitian ini dilakukan dengan pembagian kuesioner NBM untuk mengetahui tingkat keluhan yang dialami oleh pekerja. Kemudian dilakukan identifikasi postur kerja dengan metode Assesment Repetitive Task (ART) dan Rapid Entire Body Assessment (REBA) untuk mengidentifikasi pergerakan seluruh tubuh sehingga dapat memberi perbaikan gerakan tubuh secara keseluruhan. Hasil penelitian ART menunjukkan nilai exposure level yang sedang, sehingga perlu dilakukan peninjauan pada stasiun kerja operator. Hasil REBA menunjukkan 1 postur kerja dengan skor REBA 12 dan 4 postur kerja dengan skor REBA 11 yang artinya perlu perbaikan saat ini juga dan 2 postur kerja dengan skor REBA 10 yang artinya perlu perbaikan segera. Hasil penelitian diketahui bahwa peralatan kerja yang digunakan selama ini berpengaruh terhadap postur kerja operator, sehingga dilakukan desain usulan peralatan kerja yaitu, kursi dan meja penggilingan
Strategi Membangun Ekonomi Sirkular Industri Maritim Nasional melalui Konsep Net Zero Emission
Authors: Komara Andi , Saragih John S. , Rasyad Kemal , Iroth Kevin T.P. , Dwiwanti Maulina , Sahubawa Sarifah U.
Published: November 2023

Penerapan strategi ekonomi sirkular industri maritim melalui konsep Net Zero Emission (NZE) dilatarbelakangi oleh target International Maritime Organization untuk menurunkan emisi gas rumah kaca (GRK) sektor pelayaran internasional dan target NZE Indonesia di tahun 2060. Penurunan emisi GRK dapat dilakukan dengan data kuantitatif Energy Efficiency Existing Ship Index dan Carbon Intensity Index yang diregulasi oleh pemerintah. Melalui strategi yang tepat, akan terbentuk ekonomi sirkular yang dapat diaplikasikan di Industri Maritim. Strategi yang dapat dilakukan berupa bahan bakar alternatif dan teknologi penunjang NZE. Dampak positif dan negatif dari penerapan konsep NZE perlu ditinjau lebih lanjut untuk menentukan langkah yang tepat. Kesimpulan yang didapatkan adalah menciptakan strategi mencapai NZE industri maritim beserta pembuatan tahapan dan rencana aksi yang mendukung.
Navigating the Waters of Cooperation: A Review of 'South Asian Rivers: A Framework for Cooperation' Edited by Imtiaz Ahmed
Authors: Shrestha Arun Bhakta
Published: November 2023

The book delves into the multifaceted aspects of water governance, encompassing legal, political, environmental, and social dimensions. It begins with Imtiaz Ahmed's insightful introduction, setting the stage for an in-depth examination of river water sharing in the region. The subsequent chapters provide a wealth of information, covering national and international legal aspects, existing agreements and institutions, public engagement, and innovative approaches for transboundary water governance.
Monkeypox Presenting as Ototoxicity and Developing into Tinnitus as a Sequela: A Case Report
Authors: Kooner Amritpal , Amatul-Hadi Faiza , Dolehide Conor
Published: November 2023

Background
A 35 year old male presented to the emergency department with ear pain and a rash of five days duration. The patient stated there was also discharge from his left ear. Two days prior the patient developed a lesion on his chin, which progressed to several circular papules with central eschar over his cheeks, behind his left ear, on his neck, and over his upper extremities. The patient’s initial ear pain developed into tinnitus as a sequela. The patient has a prior history of AIDS which is being managed with Symtuza and Bactrim.
Monkeypox is a zoonotic viral disease caused by the Monkeypox virus, a member of the Orthopoxvirus genus. Transmission occurs through direct contact with infected individuals, or contact with respiratory droplets, bodily fluids, or contaminated objects. Initially monkeypox presents with flu-like symptoms, followed by the development of a distinctive rash. 
Results
The case demonstrates a unique example of otalgia that developed into tinnitus in an AIDS patient infected with Monkeypox. Previous studies have reported clinical presentation of Monkeypox as rashes in penile, perianal, and pharyngeal areas, tonsillitis, epiglottis, bronchopneumonia, myocarditis, and encephalitis. However, there are currently no cases describing otalgia and tinnitus as a presentation and adverse complication of Monkeypox in the literature. An in-depth review of the current presentations and adverse complications of Monkeypox provides a foundation for improving diagnostic accuracy, patient management, and public health response strategies in affected areas. The examination of diverse clinical presentations and potential complications associated with Monkeypox, aids healthcare professionals in differentiating monkeypox from similar conditions, such as chicken pox or herpes zoster, leading to a more accurate diagnosis and reduced spread of the disease.
Conclusion
The identification of new clinical presentations for Monkeypox is important for public health for early diagnosis and reducing onward transmission. Consolidation of the current knowledge on unique presentations and adverse complications of Monkeypox serves as a valuable resource for future research endeavors.
A Novel Web-Based eMemo for Tertiary Institutions in Developing Nations: From Conceptualization to Implementation
Authors: OLABANJO Olusola , WUSU Ashiribo , ARIBISALA Benjamin
Published: November 2023

The new need to move to an online mode of
administration has necessitated the adoption of Software-as-a-Service (SaaS) and
Platform-as-a-Service (PaaS). The conventional paper-based administrative memorandum
is relatively costly, requires manpower, insecure and non-confidential, prone
to unauthorized access and has a relatively slow cycle time; among others. An
electronic memo (e-memo) can save cost, offer high speed of processing, reliability
and security. The aim of this work was to conceptualize, design and develop a novel
semantic web-based memo platform that allows for handling memos within an organization.
The tools used include HTML, CSS, PHP, JavaScript, jQuery and AJAX, MySQL. The developed system was tested in three stages. Testing was done in the Department
of Computer Science of the institution of case study, then in the Faculty of
Science and finally in the entire Lagos State University. Agile development
method was used in the development process. The designed system was hosted on a
cloud-server and a total of 43 test cases were considered and an average of four
minutes was recorded for a complete memo cycle. eMemo allows users to generate,
sign, treat and memo electronically. It is such a useful tool that will enhance
information processing in a faster, standardized and more secure manner.
Art master Yulia Gusarova is an artist of multifaceted talent
Authors: Nekrasova-Karateeva Olga Leonidovna
Published: November 2023

The article contains materials about the work of St. Petersburg artist Yulia Vasilievna Gusarova, a master who creates works in different materials and techniques and has her own theme, manner and style. The purpose of the article is to determine the foundations and nature of creativity, to track the dynamics of the personal development of a hereditary artist. She is multi-faceted and is successfully realized in the art of painting, in mosaics, in ceramics, in textiles, in scientific and pedagogical activities. The main themes of her work: stories from the history of culture and art, travel impressions, the world of the sea and marine life, the fantastic world of the medieval "bestiary" and modern technology. The article presents examples of her works, describes their semantic content and artistic merits, notes theoretical and methodological-pedagogical aspects of the problems of art and art education. The materials of the article have novelty, because they are offered for publication for the first time. There was no scientific study of Y. Gusarova's creativity in domestic and foreign art criticism. The results and research methods in this article can be useful in art criticism for use in writing monographic works about the work of other artists, as well as for creating a complete picture of the features of the work of domestic ceramic artists of the XX - XXI centuries.
Nanosecond pulse X-ray emission source based on ultrafast laser modulation
Authors: Li Yun , Su Tong , Sheng Li-Zhi , Zhang Rui-Li , Liu Duo , Liu Yong-An , Qiang Peng-Fei , Yang Xiang-Hui , Xu Ze-Fang ,   State Key Laboratory of Transient Optics and Photonics, Xi’an Institute of Optics and Precision Mechanics, Xi’an 710119, China,   School of Optoelectronics, University of Chinese Academy of Sciences, Beijing 100049, China,   School of Mathematics and Physics, Handan University, Handan 056005, China
Published: November 2023

In response to the growing demand for miniaturized ultrafast pulsed X-ray sources in the fields of fundamental science and space applications, we design and develop an ultrafast pulsed X-ray generator based on a laser-modulated light source and a photoelectric cathode. This innovative technology addresses the limitations commonly encountered in traditional X-ray emission devices, such as low repetition rate, insufficient time stability, and suboptimal pulse characteristics.

Our effort is to study and develop the ultrafast modulation control module for the pulsed X-ray generator. This effort results in achieving high levels of time accuracy and stability in ultrafast time-varying photon signals. Moreover, we successfully generate nanosecond pulsed X-rays by using a laser-controlled light source.

Theoretically, we establish a comprehensive time response model for the pulsed X-ray generator in response to short pulses. This includes a thorough analysis of the time characteristics of the emitted pulsed X-rays in the time domain. Experimentally, we conduct a series of tests related to various time-related parameters of the laser-controlled light source. Additionally, we design and implemente an experimental test system for assessing the time characteristics of pulsed X-rays, by using an ultrafast scintillation detector.

The experimental results clearly demonstrate that our pulsed X-ray generator achieves impressive capabilities, including high repetition rates (12.5 MHz), ultrafast pulses (4 ns), and exceptional time stability (400 ps) in X-ray emission. These results closely align with our established theoretical model. Compared with traditional modulation techniques, our system exhibits significant improvement in pulse time parameters, thereby greatly expanding its potential applications.

This research provides a valuable insight into achieving ultra-high time stability and ultrafast pulsed X-ray emission sources. These advances will further enhance the capabilities of X-ray technology for scientific research and space applications.
Molecular structures in the non-adiabatic relaxaiton processes of excited states of pentafluoropyridine
Authors: Li Duo-Duo , Zhang Song ,   State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan 430071, China,   University of Chinese Academy of Sciences, Beijing 100049, China
Published: November 2023

In this work, the molecular structure and energy of some critical points in nonradiative relaxation process of the excited state of pentafluoropyridine are studied through quantum chemistry calculation. The structures and the vertical excitation energies and adiabatic excitation energies of the ground state and two lowest exited states are calculated. The geometry of the ground state is a planar structure with C2v symmetry, while the geometries of the two lowest excited states are half-boat structures with out-of-plane distortions. Furthermore, the topology structures and energy of the conical intersections of S2/S1, S1/S0 and S2/S0 are determined. The topology structures of the conical intersections S2/S1, S1/S0 and S2/S0 in the branching space are all peaked with asymmetric structures, and are determined to be structure of boat, half-boat, and chair, respectively. Their corresponding energy values are estimated at 6.39, 5.16 and 8.51 eV, respectively. The results show that the primary non-adiabatic relaxation pathway is the wavepacket of the S2 state rapidly evolving into the S1 state via the S2/S1, and then directly relaxing to the ground state via the S1/S0. In addition, the probability of directly relaxing to the ground state through S2/S0 is smaller.
Differential regulation of hair cell actin cytoskeleton mediated by SRF and MRTFB
Authors: Zhou Ling-Yun , Jin Chen-Xi , Wang Wen-Xiao , Song Lei , Shin Jung-Bum , Du Ting-Ting , Wu Hao
Published: November 2023

The MRTF–SRF pathway has been extensively studied for its crucial role in driving the expression of a large number of genes involved in actin cytoskeleton of various cell types. However, the specific contribution of MRTF–SRF in hair cells remains unknown. In this study, we showed that hair cell-specific deletion of Srf or Mrtfb, but not Mrtfa, leads to similar defects in the development of stereocilia dimensions and the maintenance of cuticular plate integrity. We used fluorescence-activated cell sorting-based hair cell RNA-Seq analysis to investigate the mechanistic underpinnings of the changes observed in Srf and Mrtfb mutants, respectively. Interestingly, the transcriptome analysis revealed distinct profiles of genes regulated by Srf and Mrtfb, suggesting different transcriptional regulation mechanisms of actin cytoskeleton activities mediated by Srf and Mrtfb. Exogenous delivery of calponin 2 using Adeno-associated virus transduction in Srf mutants partially rescued the impairments of stereocilia dimensions and the F-actin intensity of cuticular plate, suggesting the involvement of Cnn2, as an Srf downstream target, in regulating the hair bundle morphology and cuticular plate actin cytoskeleton organization. Our study uncovers, for the first time, the unexpected differential transcriptional regulation of actin cytoskeleton mediated by Srf and Mrtfb in hair cells, and also demonstrates the critical role of SRF–CNN2 in modulating actin dynamics of the stereocilia and cuticular plate, providing new insights into the molecular mechanism underlying hair cell development and maintenance.
Effect of α-tubulin acetylation on the doublet microtubule structure
Authors: Yang Shun Kai , Kubo Shintaroh , Black Corbin Steven , Peri Katya , Dai Daniel , Legal Thibault , Valente-Paterno Melissa , Gaertig Jacek , Bui Khanh Huy
Published: November 2023

Acetylation of α-tubulin at the lysine 40 residue (αK40) by αTAT1/MEC-17 acetyltransferase modulates microtubule properties and occurs in most eukaryotic cells. Previous literatures suggest that acetylated microtubules are more stable and damage resistant. αK40 acetylation is the only known microtubule luminal post-translational modification site. The luminal location suggests that the modification tunes the lateral interaction of protofilaments inside the microtubule. In this study, we examined the effect of tubulin acetylation on the doublet microtubule (DMT) in the cilia of Tetrahymena thermophila using a combination of cryo-electron microscopy, molecular dynamics, and mass spectrometry. We found that αK40 acetylation exerts a small-scale effect on the DMT structure and stability by influencing the lateral rotational angle. In addition, comparative mass spectrometry revealed a link between αK40 acetylation and phosphorylation in cilia.
Recopilación de trabajos realizados con el sistema de predicción de ventas de empresas proveedoras de productos químicos
Authors: Estrada Ma. del Rocío Castillo , Camarillo Marco Edgar Gómez , Castillo Marco Edgar Gómez , Gómez Modesto Javier Cruz
Published: November 2023

El presente artículo resume los trabajos realizados sobre el Sistema de Predicción de Ventas para Empresas Proveedoras de Productos Químicos; el Sistema originalmente se desarrollo en Excel, utilizando cinco técnicas de pronóstico ampliamente utilizadas; posteriormente, se desarrolló un software que calcula los pronósticos utilizando las cinco técnicas y una sexta que se propuso y se denominó Doble Promedio Móvil Ponderado (DPMP), adicionalmente con el fin de establecer la precisión de los pronósticos, se probaron siete medidas de error. El programa calcula los pronósticos mensuales y anuales para cada técnica y sus errores contra las ventas reales, selecciona la de menor error y elabora gráficas para cada producto. El programa está escrito en lenguajes PHP y HTML es ejecutable en distintos sistemas operativos, mediante el software XAMPP (usando el modulo del servidor Apache) y se puede utilizar para cualquier tamaño de empresa: pequeña, mediana y grande, solo cambiando el tamaño de la matriz; actualmente, el software está registrado en SEP-INDAUTOR, con número de folio 03-2016-042510554500-01.El resultado de las pruebas con datos de ventas de dos empresas fue: con el software propuesto se mejoró las predicciones en más del 90% de los productos, la técnica propuesta DPMP resulto tener mejor desempeño para la empresa uno y ser la tercera en desempeño para la empresa dos y las medidas de error mas adecuadas: error porcentual absoluto medio simétrico (SMAPE) y error porcentual absoluto arcotangente medio (MAAPE).
Analysis of the graduate and postgraduate courses demand on Feira de Santana industry
Authors: Alves Edillane Silva , Almeida Kalil Figueiredo , Carvalho João Luiz Carneiro , De Souza Nilmar , Lora Fábio André , Martins Luís Oscar Silva , Santos André de Mendonça , Santos Adillys Marcelo da Cunha , Damm Djoille Denner
Published: November 2023

The municipality of Feira de Santana plays a pivotal role in the economic growth in the state of Bahia. According to data from the Brazilian Institute of Geography and Statistics (IBGE), the municipality has approximately 624,000 inhabitants and a Gross Domestic Product (GDP) of around 15 billion Brazilian reais annually, ranking as the 3rd largest in Bahia and the 74th in Brazil. To ensure the continuous economic growth of the municipality, there is a pressing need for a qualified workforce. Therefore, the aim of this study is to systematically examine and analyze the demand for undergraduate and postgraduate programs in the industry of Feira de Santana. The methodology employed was based on data collection, incorporating both qualitative and quantitative approaches, from industries located in Feira de Santana and the microregion within the Portal do Sertão. The project's development encompassed six stages: 1 – selection of the data collection instrument; 2 – formulation of a questionnaire with closed-ended questions; 3 – creation of an electronic questionnaire; 4 – data collection; 5 – data analysis; 6 – presentation of the study’s results at technical and scientific events. Results indicate a demand for undergraduate programs in Engineering or Management and a postgraduate program in the field of Management in the form of MBA specialization. It is noteworthy that currently, the Center for Science and Technology (CETENS) at the Federal University of Recôncavo da Bahia (UFRB) does not offer the community Management courses such as Administration, Accounting, or Economics, nor does it offer postgraduate courses in the same area. Thus, we identified two growth vectors in the project. The first is based on the ongoing expansion of Engineering/Technology courses, such as Chemical Engineering, Computer Science, Automation, and Architecture. The second vector is focused on management courses, as mentioned earlier. A study was conducted to understand the problems and difficulties encountered during the project's execution using quality tools such as Brainstorming (BS), Ishikawa, 5 Whys, 5W2H, and PDCA. A proposed solution was put forth for the continuation of activities. An analytical study was carried out, stratifying the 627 industries in Feira de Santana, and a recommendation of 27 undergraduate courses was suggested to meet this demand. Nevertheless, the results indicate the strengthening of the relationship between CETENS and the industry, a potential improvement in the future employability of CETENS graduates, and the proposal of guidelines for the development and introduction of new undergraduate and postgraduate courses at the advanced campus of CETENS/UFRB.
Financial distress e governança corporativa: um estudo no mercado de capitais brasileiro
Authors: Dos Santos Renato Ribeiro , Peixoto Fernanda Maciel
Published: November 2023

A governança corporativa é uma área crescente dos estudos em gestão, especialmente para economias em desenvolvimento onde suas práticas têm se tornado um ponto focal para os pesquisadores. O objetivo do estudo é investigar o impacto de mecanismos de GC sobre a probabilidade de financial distress de empresas brasileiras não financeiras listadas na B3 no período de 2010 a 2022. A pesquisa analisa a relação entre concentração acionária, composição do conselho de administração e propriedade estatal com financial distress, e também foram analisadas variáveis de auditoria, COVID19 e regionalidade. O método adotado foi a regressão logística e a proxy para financial distress foi baseada na pontuação Z-Score de Altman (1968). Como principais resultados, constatou-se que quando a empresa tem propriedade estatal, alta concentração acionaria e dualidade do CEO, ela tem maior probabilidade de apresentar financial distress. Já as variáveis de auditoria, Covid19, retorno sobre o patrimônio líquido, e retorno sobre o lucro líquido são negativamente relacionados ao FD. Por fim o estudo contribuiu com a literatura no monitoramento sobre o risco de falência, prosperidade dos negócios e prevenção de restrições financeiras, trazendo implicações importantes para a estabilidade financeira das firmas brasileiras.
Role of Instrument-assisted Soft Tissue Mobilisation in Text Neck Syndrome: A Quasi-experimental Study
Authors: Aggarwal Amita , Lahoti Anuj Pawan , Palekar Tushar J
Published: November 2023

Introduction: Text Neck Syndrome occurs due to sustained Forward Head Posture (FHP) when smartphones are used constantly without any breaks for more than five hours and with improper posture. Long-term untreated text neck can cause inflammation of the neck’s ligaments, muscles, and nerves, leading to chronic arthritic changes. Literature provides studies evaluating the effects of physical or manual therapy, but there is a lack of studies investigating the effects of Instrument-assisted Soft Tissue Mobilisation (IASTM) treatment in individuals with text neck syndrome. Aim: To determine the added effect of IASTM on text neck syndrome. Materials and Methods: This quasi-experimental study was conducted at Department of Physiotherapy, Dr. D.Y. Patil College of Physiotherapy, Pune, Maharashtra, India, from August 2022 to December 2022. A total of 22 subjects, with a mean age of 21.58±1.18 years, participated in the study. The subjects were then divided into two treatment groups (n=11 each). The experimental group (Group-A) received stretching, strengthening exercises with IASTM, while the control group (Group-B) received only conventional physical therapy (stretching and strengthening). The treatment was delivered for a twoweek period. The data were analysed using MedCalc statistical software version 20.210. Significance was set at a p-value less than 0.05. For within-group analysis, Wilcoxon’s signed-rank or paired t-test was used depending on the normality distribution, and for between-group comparisons, Mann-Whitney tests were used for skewed variables. Results: The pain severity (p-value=0.0063) and neck disability (p-value=0.0008) were significantly lower in the IASTM group than the control group. Additionally, the Craniovertebral Angle (CVA) (p-value=0.0001) significantly increased with IASTM (Group-A) compared to the control group. Conclusion: The study concluded that IASTM and conventional therapy are individually effective in improving pain, disability, and FHP in text neck syndrome. However, adding IASTM to routine physical therapy showed statistically more significant results compared to physical therapy alone in reducing neck pain, disability, and FHP.
Rare Case of Bladder Endometriosis in a Post-hysterectomy Patient
Authors: Sengupta Rajasi Kane , Inamdar Saunitra , Tayade Surekha
Published: November 2023

Bladder endometriosis, a rare but well-known condition with a high risk of morbidity, affects the bladder. A 43-year-old woman presented with a history of recurrent cyclical discomfort during urination. The patient had undergone a non descent vaginal hysterectomy to address the same symptom. Upon examination, a nodule was discovered between the bladder and vaginal vault. The diagnosis of bladder endometriosis was confirmed through cystoscopy and an Magnetic Resonance Imaging (MRI). The nodule was removed via transurethal resection, and histology confirmed it as endometriosis. After 12 months of follow-up, the patient's postoperative symptoms had completely resolved. Hormonal therapy was initiated, and there were no residual urinary symptoms, chronic pain, or cyclical pain. Women reporting urinary symptoms, particularly those with a history of pelvic surgery, should undergo evaluation for bladder endometriosis. The diagnosis of bladder endometriosis should be considered in women experiencing dysuria and bladder discomfort. A high index of suspicion is required to establish the diagnosis.
The Effect of Substitute Feed of Fish Meal and Meat Bone Meal (MBM) on Growth Performance and Survival Rate of Juvenile Tilapia (Oreochromis niloticus)
Authors: Nur’Izmha Dennysha Priecilla Aulia , Haetami Kiki , Subhan Ujang , Andriani Yuli
Published: November 2023

The research aims to create a feed formulation based on the use of meat bone meal (MBM) to improve the production performance of juvenile tilapia. The experiment method used was an experimental method using a Completely Randomized Design (CRD), consisting of 5 treatments and 3 replications: treatment A (control/commercial feed), B (fish meal 75%:25% MBM), C (fish meal 50%:50% MBM), D (fish meal 25%:75% MBM), and E (fish meal 0% 100% MBM). The juvenile tilapia used were 5-8 cm in length and weighed 5,85 ± 0,029 g. The results showed  that the effects of substitution of fish meal and MBM for each treatment were significantly different (P<0,05) on the parameters of the production performance of juvenile tilapia. Treatment D gave  the best result on production performance, namely SGR (1,45 ± 0,139%g/day) and SR (97 ± 0,82%).
You Are What You Eat: Preventive Roles of Antioxidant Phytochemicals on Age-related Eye Diseases
Authors: Moyegbone John E. , Onoikhua Eghonghon E. , Fregene Favour A. , Jacob Kingsley N. , Efejene Israel O. , Anowa Edmond I. , Akuirene Omatseye A. , Agege Emmanuel E. , Odoko Joseph O. , Nwose Ezekiel U.
Published: November 2023

Aim: What we eat plays a vital role in human health with no exception to the eye which results to either good or poor vision. This review aimed at determining how what we eat affect age-related eye diseases and the role of antioxidants in phytochemical compound in preventing age-related eye diseases.

Study Design: A non-systematic review and evaluation of published literatures was done through web search engines such as PubMed and Google Scholar using Mendeley reference library for citation.

Methodology: A total of 48 articles were reviewed using the key words such as ‘’you are what you eat,’’ Age-related eye diseases, Antioxidants, Phytochemical compounds, Oxidative Stress and Free Radicals

Results: Increased consumption of energy-dense foods such as refined grains, processed meats, added sugar and saturated fatty foods might increase the risk of obesity, insulin resistance, chronically elevated blood glucose, chronic systemic inflammation, oxidative stress, and increased protein damage leading to initiation and progression of systemic diseases such as diabetes, hypertension, heart related diseases, as well as age-related eye diseases such as cataract, glaucoma, diabetic retinopathy, and macular degeneration. Findings also showed that many botanical compounds such as curcumin, lutein and zeaxanthin, ginseng, and many more, present in food exhibit strong antioxidative, anti-inflammatory, and antiapoptotic properties that helps in ameliorating the destructive roles of oxidative stress.

Conclusion: Phytochemicals with proven antioxidant and anti-inflammatory activities, such as carotenoids and polyphenols, could be of benefit in preventing age-related eye diseases. Consumption of products containing these phytochemicals is recommended to provide noninvasive alternatives for protection, prevention and treatments of the major systemic and age-related eye diseases.
Screening of Promising Genotypes of Isabgol against Downy Mildew Disease (Peronospora plantaginis)
Authors: Kasif Adeel Abrar , Mishra R. S. , Raghuvanshi Vishwa Vijay , Patel Shyam Narayan , Singh Shivam , Siddharth Prabha
Published: November 2023

Isabgol (Plantago ovata) is an important Rabi crop grown in dry regions of India. It plays an important role in reducing stomach disorders. The crop of Isabgol suffers with number of diseases. Downy mildew disease of Isabgol caused by Peronospora plantaginis is one of the wide spread and destructive diseases in India. The symptoms of downy mildew of Isabgol appear 30-35 days after sowing. As the disease progressed, the leaves become necrotic and started drying from the tip to backward and plant become stunted. The genotype screening is an eco-friendly method for management of plant diseases; hence an experiment was conducted to identify the resistant genotypes against downy mildew of Isabgol under natural field condition. Out of 36 genotypes, 8 genotypes were found resistant, 15 genotypes were found moderately resistant, 8 genotypes were found moderately susceptible and 5 genotypes were found susceptible against downy mildew of Isabgol.
Soil Biodiversity: Influence of Soil Management Systems
Authors: Divya S. N. , Priya Gowri , Rani B. , Aparna B. , Soumya V. I. , Gopinath P. P.
Published: November 2023

Aim: Soil represents one of the most diverse habitats found on our planet. Soil organisms play crucial roles within ecosystems by exerting influence over physical properties and processes, as well as contributing to carbon and energy fluxes and the cycling of nutrients. The activity and composition of soil organisms are significantly impacted by land use and land management practices. In this study, we examined the predominant functional groups present in soil two different soil management systems viz., organic and integrated nutrient management (INM).

Methods: We collected soil samples from coconut-based cropping systems under organic soil management and integrated nutrient management. Soil samples were characterised for soil macrofauna, mesofauna, microfauna and microflora.

Results: The presence of soil macrofauna, mesofauna, microfauna, and microflora was more pronounced under organic management. Furthermore, the PERMANOVA analysis indicated that while management practices did not significantly impact community dissimilarity in the study area, the depth of the soil did have a significant influence.

Conclusion: Although the PERMANOVA analysis within the light conditions examined, revealed that the influence of management practices on community dissimilarity was not statistically significant, it was noted that organic management led to an enhancement in soil biodiversity. The results of this study offer a comprehensive evaluation of the manner in which the organic management and INM practices influence the biodiversity of the soil.
Influence of Organic Seaweed Pelleting on Seed Quality Parameters of Onion Seeds
Authors: Elamparithi R. , Sujatha K.
Published: November 2023

Aim: Small and irregular seed shapes make precision sowing difficult. Seed pelleting, which helps to make seed handling easier during sowing, is converting such seeds into bold, spherical shapes with a smooth surface. Seaweeds are a rich source of nutrients that promote growth, such as IAA, kinetin, zeatin, and gibberellins; auxins and cytokinins; metabolic enhancers; macro and micro elements; amino acids; and vitamins. Their use in crop plants has been shown to have positive effects, including early seed germination and establishment, improved crop performance and yield, increased resistance to biotic and abiotic stress, and increased seed shelf life (Bluden).

Study Design: The experiment was undertaken with three replications in a completely randomized block design. Eight treatmental combinations were used in this study. Statistical analysis was carried out by AGRES software. The Critical Differences (CD) was calculated at 5 per cent probability level.

Place and Duration of Study: Department of Seed Science and Technology, Agriculture College and Research Institute, TNAU, Madurai, during the period of December 2020 and November 2021.

Methodology: Organic seaweed pellet combinations can be successfully implemented to provide improved field emergence, crop establishment and production. Seeds were pelleted with different mixtures of Sargassum sp., Kappaphycus sp., Bacillus subtilis and Talc powder.

Results: The results exposed that between the treatments seed pelleting with combination of T7- Sargassum sp + Kappaphycus sp + Bacillus subtilis+ Talc powder was found to be more efficient in comparison with other combinations.

Conclusion: Pelleting with, Kappaphycus sp, Bacillus subtilis and Talc powder was found to be better in all aspects of seed quality and biochemical parameters.
Impact of Factor VII Polymorphism on Responsiveness to Warfarin Anticoagulant Therapy
Authors: Shaaban Omyma Hassan , Serogy Hesham Ahmed El , Zahra Mohamed Kamal , Abourahma Amr Mahmoud
Published: November 2023

Background: Oral anticoagulants (OAs) are drugs prescribed to reduce the risk of stroke and systemic embolism in non-valvular atrial fibrillation patients, and to treat and decrease the incidence of deep vein thrombosis and pulmonary embolism. We aimed to clarify the impact of factor VII (FVII) polymorphism on the extent of anticoagulation exerted by warfarin therapy.

Methods: The study was performed on 30 patients on warfarin therapy with international normalized ratio (INR) 2-3, 21 of them for cardiac causes, 2 of them for orthopedic causes and the remaining 7 patients for vascular causes. They were subjected to warfarin therapy (Marevan), laboratory investigations (Prothrombin time (PT) and INR, FVII activity by coagulometric method, plasma warfarin level (by high performance liquid chromatography), and detecting FVII polymorphism (-401G/T & -402 G/A) by polymerase chain reaction).

Results: Regarding the coagulation indicators of the patients with various FVII- 402 genotypes, PT time was significantly lower in homozygous mutant than heterozygous (P=0.032). Also, it was non significantly lower than that of wild type. PT time was non significantly lower in wild type than heterozygous. PT activity was significantly higher in homozygous mutant than heterozygous (P=0.032). Also, it was non significantly higher than that of wild type. PT activity was non significantly higher in wild type than heterozygous. There was significant difference as regard warfarin sensitivity index (WSI) between wild type and homozygous mutant. Marevan dose was significantly lower in wild type than homozygous mutant and heterozygous. Regarding the coagulation indicators of the patients with various FVII -401 genotypes, WSI was lower in wild type than heterozygous and homozygous mutant, however, it was significantly different between wild type compared to homozygous and heterozygous genotypes (P<0.001). Marevan dose was significantly higher in wild type than homozygous mutant (P<0.001), and it was non significantly higher in heterozygous than homozygous mutant.

Conclusions: Marevan dose was significantly lower in wild type than homozygous and heterozygous mutant as regard FVII -402 G/A, while regarding FVII -401 G/T, marevan dose was significantly higher in wild type than homozygous mutant. Polymorphisms in FVII genes may play a significant role in modulating the warfarin’s anticoagulant effect.
Prevalence of Obsessive-Compulsive Disorder among Medical Students at Taibah University, Saudi Arabia
Authors: Makki Nadir Mohamed , Alharbi Abdulrahman Mohammad , Aljohani Ammar Mousa , Aljohani Saleh Saud , Jan Hassan Kamel , Almukhlifi Ayman Shabab
Published: November 2023

Background: Obsessive-compulsive disorder (OCD) is a prevalent mental disorder. It has an onset during the late teens, thus putting university students at higher risk as a target group. They live in an environment that is full of stressors and factors that may lead to the expression of obsessive compulsion symptoms. The objective of the present research is to explore the prevalence of OCD and its associated symptoms among medical students.

Materials and Methods: Cross-sectional analytic research at Taibah University in which medical students participated during a year period from December 2021 to 2022. Data collection was through an online self-administered questionnaire with 18 questions on the Obsessive-Compulsive Inventory-Revised scale (OCI-R) filled out anonymously as well as voluntarily.

Results: According to the OCI-R used in the study, 69 out of 263 (26%) participants are found to have probable OCD. There was a statistically significant association between participants who reported a history of mental illness and the probability of OCD [p=0.002]. Also, age groups showed statistically significant differences [p=0.007] as well as between academic years [p=0.003], with an increase in the probability of OCD with younger age and early academic years

Conclusions: This current study has shown a high OCD prevalence among medical students at Taibah University, consistent with other similar studies. There were significant correlations with age, academic year, and history of mental illnesses, especially depression and anxiety.
Relationship between imaging parameters and distortion in magnetic resonance images for gamma knife treatment planning
Authors: Koori Norikazu , Kamekawa Hiroki , Mukawa Nanami , Fuse Hiraku , Miyakawa Shin , Yasue Kenji , Takahashi Masato , Yamada Masanori , Henmi Atsushi , Kusumoto Toshifumi , Kurata Kazuma
Published: November 2023

In magnetic resonance imaging (MRI), it is necessary to reduce image distortion as much as possible because it suppresses the increase in the planning target volume. This study investigated the relationship between imaging parameters and image distortion when using G‐frames. The images were obtained using a 1.5‐T MRI system with a 09‐101 Pro‐MRI phantom. Image distortion was measured by changing the RF pulse mode, gradient mode, asymmetric echo, and bandwidth (BW). The image distortion was increased in the high RF mode than in the Normal mode. The image distortion increased in the following order: Whisper ≦ Normal < Fast in the different gradient modes. The image distortion increased in the following order: Without ≦ Weak < Strong in the different asymmetric echo modes. The image distortion increased in the following order: 300 Hz/pixel > 670 Hz/pixel ≧ REF (150 Hz/pixel) in the different Bw. The relationship between parameters and image distortion was clarified in this study when G‐frames were used for gamma knife therapy. There is had relationship between the parameters causing variation in the gradient magnetic field and image distortion. Therefore, these parameters should be adjusted to minimize distortion.
Glutathione and bicarbonate nanoparticles improve mucociliary transport in cystic fibrosis epithelia
Authors: Cho Do Yeon , Rivers Nicholas J. , Lim Dong‐Jin , Zhang Shaoyan , Skinner Daniel , Yang Lydia , Menon Adithya J. , Kelly Olivia Jo , Jones Martin P. , Bicknell Brenton T. , Grayson Jessica W. , Harris Elex , Rowe Steven M. , Woodworth Bradford A.
Published: November 2023

Introduction

Cystic fibrosis (CF) airway disease is characterized by thick mucus and impaired mucociliary transport (MCT). Loss of functional cystic fibrosis transmembrane receptor (CFTR) leads to acidification and oxidation of airway surface mucus. Replacing bicarbonate (HCO3−) topically fails due to rapid reabsorption and neutralization, while the scavenging antioxidant, glutathione sulfhydryl (GSH), is also rapidly degraded. The objective of this study is to investigate GSH/NaHCO3 nanoparticles as novel strategy for CF airway disease.

Methods

GSH/NaHCO3 poly (lactic‐co‐glycolic acid) nanoparticles were tested on primary CF (F508del/F508del) epithelial cultures to evaluate dose‐release curves, surface pH, toxicity, and MCT indices using micro‐optical coherence tomography. In vivo tests were performed in three rabbits to assess safety and toxicity. After 1 week of daily injections, histopathology, computed tomography (CT), and blood chemistries were performed and compared to three controls. Fluorescent nanoparticles were injected into a rabbit with maxillary sinusitis and explants visualized with confocal microscopy.

Results

Sustained release of GSH and HCO3− with no cellular toxicity was observed over 2 weeks. Apical surface pH gradually increased from 6.54 ± 0.13 (baseline) to 7.07 ± 0.10 (24 h) (p < 0.001) and 6.87 ± 0.05 at 14 days (p < 0.001). MCT, ciliary beat frequency, and periciliary liquid were significantly increased. When injected into the maxillary sinuses of rabbits, there were no changes to histology, CT, or blood chemistries. Nanoparticles penetrated rabbit sinusitis mucus on confocal microscopy.

Conclusion

Findings suggest that GSH/NaHCO3− nanoparticles are a promising treatment option for viscous mucus in CF and other respiratory diseases of mucus obstruction such as chronic rhinosinusitis.