bluuebunny/crossref_metadata_2025 huggingface dataset:
Local Government Competition and Regional Green Development in China: The Mediating Role of Environmental Regulation
Authors: Zhang Na , Deng Jinqian , Ahmad Fayyaz , Draz Muhammad Umar
Published: May 2020

Green development is an important way to meet the challenges of ecological and environmental protection and economic growth, as well as an inevitable choice to realize China’s sustainable development in the new era. The Chinese economic system is such that local government competition has become a key factor affecting regional green development under the current leadership. Based on the inter-provincial panel data of 30 provinces in mainland China from 1997 to 2017, this paper uses the total-factor non-radial directional distance function and slack-based measure data envelopment analysis (SBM-DEA) to measure the green development efficiency of the provinces. Additionally, it also uses the Malmquist–Luenberger (ML) index to decompose green development efficiency and analyzes its internal driving factors. Finally, taking environmental regulation as a mediating variable, this paper empirically analyzes the influence mechanism of local government competition on green development efficiency from three perspectives including growth competition, fiscal competition and investment competition. The study found that: the green development efficiency of Chinese regions showed a downward trend, with significant regional differences; technological progress is the key factor to improve the efficiency of green development, and its role gradually decreases from eastern to western and central regions; pure technical efficiency has become a bottleneck restricting the improvement of green development efficiency, while scale efficiency shows significant regional differences; the growth competition, fiscal competition and investment competition of local government all have a significant inhibitory effect on the efficiency of green development. This paper puts forward policy suggestions supporting enterprise technology research and development, optimizing energy conservation and emission reduction as well as improving the local government performance evaluation system for green development.
Incidence and Risk Assessment for Atrial Fibrillation at 5 Years: Hypertensive Diabetic Cohort
Authors: Muria-Subirats Eulalia , Clua-Espuny Josep , Ballesta-Ors Juan , Lorman-Carbo Blanca , Lechuga-Duran Iñigo , Fernández-Saez Jose , Pla-Farnos Roger ,   on behalf members of AFRICAT Group
Published: May 2020

(1) Background: The link between diabetes and hypertension is mutual and reciprocal, increasing the risks for the development of atrial fibrillation (AF). The main objective was to develop a prediction model for AF in a population with both diabetes and hypertension at five years of follow-up. (2) Methods: A multicenter and community-based cohort study was undertaken of 8237 hypertensive diabetic patients without AF between 1 January 2103 and 31 December 2017. Multivariate Cox proportional-hazards regression models were used to identify predictors AF and to stratify risk scores by quartiles. (3) Results: AF incidence was 10.5/1000 people/years (95% confidence interval (CI) 9.5–11.5), higher in men. The independent prognostic factors identified: age (hazard ratio (HR) 1.07 95% CI 1.05–1.09, p < 0.001), weight (HR 1.03 95% CI 1.02–1.04, p < 0.001), CHA2DS2VASc score (HR 1.57 95% CI 1.16–2.13, p = 0.003) and female gender (HR 0.55 95% CI 0.37–0.82, p = 0.004). Q4 (highest-risk group for AF) had the highest AF incidence, stroke and mortality, and the smallest number needed to screen to detect one case of AF. (4) Conclusions: Risk-based screening for AF should be used in high cardiovascular risk patients as the hypertensive diabetics, for treatment of modifiable cardiovascular risk, and monitoring AF detection.
Regional Disparities in the Decline of Anemia and Remaining Challenges among Children in Tanzania: Analyses of the Tanzania Demographic and Health Survey 2004–2015
Authors: Sunguya Bruno F. , Zhu Si , Paulo Linda Simon , Ntoga Bupe , Abdallah Fatma , Assey Vincent , Mpembeni Rose , Huang Jiayan
Published: May 2020

The burden of child anemia is on the decline globally but remains prevalent in low- and middle-income countries, including Tanzania. Evidence suggests regional variation and a slow pace of decline even in areas with high food production. The factors behind such decline and remaining challenges behind child anemia remain understudied in Tanzania. This secondary data analysis utilized data including 7361 and 7828 children from the Tanzania Demographic and Health Surveys (TDHS) conducted in 2004–2005 and 2015–2016 separately to examine the decline of child anemia and regional variation thereof. We used a geographic information system (GIS) to visualize the changes and differences between regions and the two study periods, and used regression analyses to examine the recent determinants of child anemia. Anemia has declined among children under five in Tanzania by 42% over a one-decade period, but remained high in relatively high food-producing regions. The risk of anemia is still higher among boys compared to girls (AOR = 1.39, p = 0.005), 41% higher among children lived in households with more than three under-five children compared to those households with only one child (p = 0.002); lower among children whose mothers were educated (p < 0.001) or had first given birth when aged over 25 (p = 0.033); and 34% less among children in the wealthiest households (p < 0.001). Efforts are needed to address social determinants of health, especially targeting women’s empowerment through decreasing the number of children and encouraging child spacing, and poverty reduction, particularly in high food producing regions.
Multilevel Job Demands and Resources: Cross-Level Effects of Competing Organizational Facet-Specific Climates on Risky Safety Behaviors
Authors: Ghezzi Valerio , Probst Tahira M. , Petitta Laura , Barbaranelli Claudio
Published: May 2020

Both individual demands (i.e., workload) and organizational demands and resources (i.e., production pressure and safety climates) may affect the likelihood that employees undertake risky safety behaviors in different ways. Adopting an organizational multilevel perspective, the aim of the present research was fourfold: (1) to examine the impact of individual-level job demands (i.e., workload) on the enactment of risky safety behaviors; (2) to evaluate the effects of coexisting and competing organizational facet-specific climates (i.e., for safety and for production pressure) on the above outcome; (3) to assess their cross-level interactions with individual job demands, and (4) to test the interaction among such organizational demands and resources in shaping risky behaviors. A series of multilevel regression models tested on surveydata from 1375 employees nested within 33 organizations indicated that high workload increases the likelihood of employees enacting risky safety behaviors, while organizational safety and production pressure climates showed significant and opposite direct effects on this safety outcome. Moreover, organizational safety climate significantly mitigated the effect of individual job demands on risky safety behaviors, while organizational production pressure climate exacerbated this individual-level relationship. Finally, organizational safety climate mitigates the cross-level direct effect of organizational production pressure climate on the enactment of risky safety behaviors.
Associations of Objectively-Assessed Smartphone Use with Physical Activity, Sedentary Behavior, Mood, and Sleep Quality in Young Adults: A Cross-Sectional Study
Authors: Grimaldi-Puyana Moisés , Fernández-Batanero José María , Fennell Curtis , Sañudo Borja
Published: May 2020

This study assesses the associations of objectively-measured smartphone time with physical activity, sedentary behavior, mood, and sleep patterns among young adults by collecting real-time data of the smartphone screen-state. The sample consisted of 306 college-aged students (mean age ± SD: 20.7 ± 1.4 years; 60% males). Over seven days of time, the following variables were measured in the participants: objectively-measured smartphone use (Your Hour and Screen Time applications), objective and subjective physical activity (GoogleFit and Apple Health applications, and the International Physical Activity Questionnaire (IPAQ), respectively), the number of hours sitting (IPAQ), mood (The Profile of Mood State (POMS)), and sleep (The Pittsburgh Sleep Quality Index (PSQI)). Multiple regressions analyses showed that the number of hours sitting per day, physical activity, and the POMS Global Score significantly predicted smartphone use (adj.R2 = 0.15). Further, participants with low levels of physical activity were more likely to increase the use of smartphones (OR = 2.981). Moreover, mood state (β = 0.185; 95% CI = 0.05, 0.32) and sleep quality (β = 0.076; 95% CI = −0.06, 0.21) predicted smartphone use, with those reporting poor quality of sleep (PSQI index >5) being more likely to use the smartphone (OR = 2.679). In conclusion, there is an association between objectively-measured smartphone use and physical activity, sedentary behavior, mood, and sleep patterns. Those participants with low levels of physical activity, high levels of sedentary behavior, poor mood state, and poor sleep quality were more likely to spend more time using their smartphones.
Effects of Cognitive Behavioral Group Program for Mental Health Promotion of University Students
Authors: Lee Soojung , Lee Eunjoo
Published: May 2020

This study aimed to explore the effects of a group cognitive behavioral program on depression, self-esteem, and interpersonal relations among undergraduate students. A non-equivalent control group pretest-posttest design was used. A convenient sample of 37 undergraduates (18 in the experimental group and 19 in the control group) at K university located in Changwon, South Korea was used. Data were collected from February 4, 2019 to June 18, 2019. The experimental group received eight sessions of the program, which were scheduled twice a week, with each session lasting 90 min. Collected data were analyzed using a chi-square test, Fisher’s exact test, independent t-test, and repeated measures ANOVA by SPSS/WIN 23.0 (SPSS, Inc., Chicago, IL, USA). The interaction of group and time was significant, indicating that the experimental group showed an improvement in depression, self-esteem, and personal relationship compared to the control group. A significant group by time interaction for depression, self-esteem, and personal relationship was also found between the two groups. The study results revealed that the group cognitive behavioral program was effective in reducing depression and improving self-esteem and interpersonal relation. Therefore, the group cognitive behavioral program can be used for promoting the mental health of students as well as for preventing depression in a university setting.
Effects of Physical Activity on the Stress and Suicidal Ideation in Korean Adult Women with Depressive Disorder
Authors: Koo Kyo-Man , Kim Kyungjin
Published: May 2020

Depressive disorder is common in many adult women in the world. It was found that depressive disorder was related to stress and suicidal ideation in Korean adult women with depressive disorder. Physical activities were effective to solve this mental disorder. Thus, the purpose of the study was to investigate the effects of physical activity (PA) on the stress and suicidal ideation of Korean adult women with depressive disorder. A sample of 1315 Korean adult women who have depressive disorder was collected, and the Korea National Health and Nutrition Examination Survey (KNHANES) was used to determine this purpose of the study. The complex samples in frequency analysis were used to identify the characteristics of the participants. The logistic regression in the complex sample design was conducted to investigate the effects of PA on the stress and suicidal ideation in Korean adult women with depressive disorder. The effects of flexibility exercise on the stress in Korean adult women with depressive disorder showed the odds ratio (OR) value of 1.434 (OR = 1.434, 95% CI = 1.043–1.973, p < 0.05). The effects of flexibility exercise on the suicidal ideation in Korean adult women with depressive disorder presented the OR value of 0.682 (OR = 0.682, 95% CI = 0.496–0.937, p < 0.05). Based on the results, the participants who did flexibility exercises were likely to have less stress and suicidal ideation than the Korean adult women with depressive disorder who did not participate in flexibility exercise. In conclusion, the flexibility exercise has played an important role in reducing and preventing stress and suicidal ideation in Korean adult women with depressive disorder.
Why Negative or Positive, If It makes Me Win? Dark Personality in Spanish Competitive Athletes
Authors: González-Hernández Juan , Cuevas-Campos Ricardo , Tovar-Gálvez María Isabel , Melguizo-Rodríguez Lucía
Published: May 2020

Research on the dark triad traits (narcissism, Machiavellianism and psychopathy) is increasingly focusing on the functional or dysfunctional influences of personality traits on cognitive, behavioural and emotional responses. Thus, studies in sport contexts have shown that athletes who participate in competitive sports have higher scores in the dark triad than those who do not. The objectives of this cross-sectional study were to evaluate the linear and predictive relationships between dark traits and competitiveness (p < 0.01), as well as to identify any differences based on sports orientation (professionals vs. amateurs). Scales SD3 (dark personality) and C−10 (competitiveness) were applied to a sample of Spanish athletes (n = 806). The results show that competitiveness is strongly related to the traits of the dark personality triad. Narcissism is related to both the desire to win and the fear of losing, while Machiavellian tendencies are high when athletes feel like losers. Finally, psychopathic tendencies are related to feelings of inferiority and fear of failure. In conclusion, the results suggest that dark personality traits are related not only to the individuality of the athletes, but also to the self-perception of both their psychological response and the competitiveness of their sporting environment.
Heavy Metals and Related Human Health Risk Assessment for River Waters in the Issyk−Kul Basin, Kyrgyzstan, Central Asia
Authors: Liu Wen , Ma Long , Li Yaoming , Abuduwaili Jilili , Abdyzhapar uulu Salamat
Published: May 2020

The water resources of Central Asia play an important role in maintaining the fragile balance of ecosystems and the sustainable development of human society. However, the lack of research on the heavy metals in river waters has a far−reaching influence on public health and the sustainable development in Central Asia. In order to reveal the possible sources of the heavy metals and to assess the associated human health risks, thirty−eight water samples were collected from the rivers of the Issyk−Kul Basin during the period with low river flow (May) and the period with high river flow (July and August), and the hydrochemical compositions and major ions of heavy metals were analyzed. No changes in hydrochemical facies were observed between the two periods and the river water type was calcium bicarbonate. Carbonate dissolution and silicate weathering controlled the variation of cations and anions in river waters from the Issyk−Kul Basin. There were some differences in the sources of heavy metals in water bodies between the two periods. During the period with low river flow, heavy metals (Cr) were closely clustered with major ions, indicating that they were mainly affected by water–rock interactions. During the period with high river flow, all heavy metals studied in this paper had different sources of major ions, and the heavy metals maybe influenced by human activities. From the human health risk assessment, the hazard quotients for all samples were less than 1, reflecting that there was no noncarcinogenic risk in the river waters of the Issyk−Kul Basin during the two sampling periods. However, the water samples with carcinogenic risk of arsenic exceeding the threshold (10−4) accounted for 21.1% of the total, indicating that there were some certain carcinogenic hazards for human health via water drinking with direct oral ingestion. The results are of certain significance for the utilization and protection of water resources in the basin as well as the protection of public health.
Optimized Forecasting Method for Weekly Influenza Confirmed Cases
Authors: Al-qaness Mohammed A. A. , Ewees Ahmed A. , Fan Hong , Abd Elaziz Mohamed
Published: May 2020

Influenza epidemic is a serious threat to the entire world, which causes thousands of death every year and can be considered as a public health emergency that needs to be more addressed and investigated. Forecasting influenza incidences or confirmed cases is very important to do the necessary policies and plans for governments and health organizations. In this paper, we present an enhanced adaptive neuro-fuzzy inference system (ANFIS) to forecast the weekly confirmed influenza cases in China and the USA using official datasets. To overcome the limitations of the original ANFIS, we use two metaheuristics, called flower pollination algorithm (FPA) and sine cosine algorithm (SCA), to enhance the prediction of the ANFIS. The proposed FPASCA-ANFIS is evaluated using two datasets collected from the CDC and WHO websites. Furthermore, it was compared to some previous state-of-the-art approaches. Experimental results confirmed that the FPASCA-ANFIS outperformed the compared methods using variant measures, including RMSRE, MAPE, MAE, and R 2 .
Musculoskeletal Symptoms among Stone, Sand and Gravel Mine Workers and Associations with Sociodemographic and Job-Related Factors
Authors: Balogun Abdulrazak O. , Smith Todd D.
Published: May 2020

Stone, sand and gravel mining (SSGM) constitutes the vast majority of mining operations in the United States. Despite musculoskeletal disorders being one of the most common occupational health problems across several industries, limited research has examined the extent of reported musculoskeletal symptoms or disorders among actively employed SSGM workers. To address this knowledge gap, cross sectional data were collected from 459 SSGM workers in the Midwestern United States to determine the prevalence of musculoskeletal symptoms. Sociodemographic and job-related factors were examined to identify possible risk factors in SSGM. Musculoskeletal symptoms of the low back (57%), neck (38%), shoulder (38%) and knee (39%) were highly prevalent among SSGM employees. The results, among other findings, showed that working more than 60 h a week increased the likelihood of musculoskeletal symptoms at the low back (OR: 4.7 95% CI: 1.9–11.5), neck (OR: 5.1, 95% CI: 2.2–11.8) and knee (OR: 4.5, 95% CI: 2.0–10.3). Working as a mechanic/maintenance worker increased the likelihood of low back (OR: 2.1, 95% CI: 1.1–4.2) and knee (OR: 2.2, 95% CI: 1.1–4.6) musculoskeletal symptoms. Intervention measures aimed at improving ergonomic hazard identification for various job tasks as well as administrative controls limiting hours worked may help reduce the burden of musculoskeletal problems in the SSGM industry.
How to Influence Rural Tourism Intention by Risk Knowledge during COVID-19 Containment in China: Mediating Role of Risk Perception and Attitude
Authors: Zhu Hui , Deng Fumin
Published: May 2020

With both cost and safety taken into account in the context of the life-threatening COVID-19 pandemic globally, rural tourism is expected to be the top choice for Chinese residents for relaxation and enhancing parent-child relationships. In this paper, a structural equation (SEM) model was proposed to compare risk knowledge, risk perception, risk aversion attitudes and behavioral intentions towards rural tourism. According to the empirical results, there was a large proportion of tourists showing preference for rural tourism recently. Potential participants in rural tourism paid most attention to the performance realization and time cost of scenic spots, while the psycho-social risk posed by COVID-19 had little impact. The inherent risk nature of risk aversion attitudes made knowledge of the pneumonia risk less effective in reducing tourists’ intentions, while knowledge of the pneumonia risk was more effective in alleviating the risk perception that potential tourists have towards rural tourism. With regard to travel intention and recommendation intention of rural tourism, the negative impacts of risk aversion attitude were more considerable compared to risk perception. Meanwhile, the parallel mediating effect of risk perception and risk aversion attitude in rural tourism needed to be taken into consideration together.
The Prevalence and Awareness Concerning Dietary Supplement Use among Saudi Adolescents
Authors: Alfawaz Hanan , Khan Nasiruddin , Almarshad Alwateen , Wani Kaiser , Aljumah Muneerah A. , Khattak Malak Nawaz Khan , Al-Daghri Nasser M.
Published: May 2020

Current dietary supplement (DS) use among Saudi school students is not well described. In this study, we aim to investigate the prevalence and predictors of DS use among adolescents. This cross-sectional study collected data via self-administered questionnaire from 1221 students (12 to 18 years). The overall prevalence of DS use was 26.2%, significantly higher in females than males (33% vs. 17.9%, p < 0.001). High proportion of female DS users demonstrated normal BMI than males (84% vs. 56.5%, p < 0.001). High percentage of male DS users were engaged in vigorous and/or high physical activity (PA) levels than female DS users (58.2% vs. 43%, p = 0.022; and 57.1% vs. 20.7%, p < 0.001, respectively). The main reasons for DS use among females were vitamin deficiency (63.3%), hair condition (37.6%) and nail health (23.5%) while in males, the main reasons were vitamin deficiency (58.4%) and body building (34.4%). The predictors of DS use in Saudi adolescents included being female, having high family income and being physically active. In conclusion, the overall prevalence and preference of DS use, though low among Saudi adolescents, was driven mostly by gender, physical activity levels and socioeconomic factors like family income. DS use guidelines and counselling among Saudi adolescents are warranted to improve public health.
Interaction between Fungal Communities, Soil Properties, and the Survival of Invading E. coli O157:H7 in Soils
Authors: Huang Guannan , Liao Jiafen , Han Ziming , Li Jiahang , Zhu Liyue , Lyu Guangze , Lu Lu , Xie Yuang , Ma Jincai
Published: May 2020

Pathogens that invade into the soil cancontaminate food and water, andinfect animals and human beings. It is well documented that individual bacterial phyla are well correlated with the survival of E. coliO157 (EcO157), while the interaction betweenthe fungal communities and EcO157 survival remains largely unknown. In this study, soil samples from Tongliao, Siping, and Yanji in northeast China were collected and characterized. Total DNA was extracted for fungal and bacterial community characterization. EcO157 cells were spiked into the soils, and their survival behavior was investigated. Results showed that both fungal and bacterial communities were significantly correlated (p < 0.01) with the survival of EcO157 in soils, and the relative abundances of fungal groups (Dothideomycetes and Sordariomycetes) and some bacterial phyla (Acidobacteria, Firmicutes, gamma- and delta-Proteobacteria)weresignificantly correlated with ttds (p < 0.01). Soil pH, EC (electric conductance) salinity, and water-soluble nitrate nitrogen were significantly correlated with survival time (time to reach the detection limit, ttd) (p < 0.05). The structural equation model indicated that fungal communities could directly influence ttds, and soil properties could indirectly influence the ttds through fungal communities. The first log reduction time (δ) was mainly correlated with soil properties, while the shape parameter (p) was largely correlated with fungal communities. Our data indicated that both fungal and bacterial communities were closely correlated (p < 0.05)with the survival of EcO157 in soils, and different fungal and bacterial groups might play different roles. Fungal communities and bacterial communities explained 5.87% and 17.32% of the overall variation of survival parameters, respectively. Soil properties explained about one-third of the overall variation of survival parameters. These findings expand our current understanding of the environmental behavior of human pathogens in soils.
The Effects of Psychological Factors on Perceptions of Productivity in Construction Sites in Japan by Worker Age
Authors: Hashiguchi Nobuki , Cao Jianfei , Lim Yeongjoo , Kubota Yasushi , Kitahara Shigeo , Ishida Shuichi , Kodama Kota
Published: May 2020

The construction industry is a work environment that poses many dangers to workers, with many hidden factors that affect work awareness. It is important for construction companies to ensure a balance between productivity and safety in the work environment. The purpose of this study was to identify relationships between the feeling of safety in the work environment, proactive work behavior, job satisfaction, work skills, team performance, and health risk indicators, such as heart rate, among construction workers of different ages. Based on previous research, we examined the hypothetical perception model. We then administered a questionnaire survey to construction workers (N = 357) employed at a Japanese construction company. Using structural equation modeling (SEM), we investigated the impact of health risk indicators on worker perceptions among young and older workers. The results showed that workers’ heart rate and body mass index (BMI) had a negative effect on the feeling of safety and proactive work behavior among older workers, but showed no significant relationship among young workers. However, regardless of workers’ age, it was clear that the feeling of safety affects job satisfaction, and that work skills and proactive work behaviors affect perceptions regarding team performance.
Better Objective Sleep Was Associated with Better Subjective Sleep and Physical Activity; Results from an Exploratory Study under Naturalistic Conditions among Persons with Multiple Sclerosis
Authors: Sadeghi Bahmani Dena , Gonzenbach Roman , Motl Robert W. , Bansi Jens , Rothen Oliver , Niedermoser Daryl , Gerber Markus , Brand Serge
Published: May 2020

Persons with multiple sclerosis (PwMS) often complain about sleep problems. There is less known about objective sleep-electroencephalography (EEG) dimensions within naturalistic conditions (i.e., home and/or familiar setting). The present cross-sectional study examined the associations between objective and subjective sleep, depression, physical activity scores, and MS-related information among PwMS in their familiar setting. The sample consisted of 16 PwMS (mean age: 50.3 years; median Expanded Disability Status Scale (EDSS): 5.5) who completed questionnaires covering subjective sleep (symptoms of insomnia, restless legs syndrome (RLS) and sleep-disordered breathing), as well as daytime sleepiness, subjective physical activity, depression, and MS-related information (fatigue, EDSS; disease-modifying treatments). Objective sleep was assessed with a mobile sleep-EEG device under naturalist conditions within the home. Descriptively, better objective sleep patterns were associated with lower sleep complaints (rs = −0.51) and daytime sleepiness (rs = −0.43), and with lower symptoms of RLS (rs = −0.35), but not with sleep-disordered breathing (rs = −0.17). More deep sleep was associated with higher moderate physical activity levels (rs = 0.56). Objective sleep parameters were not associated with vigorous physical activity levels (rs < 0.25). Descriptively, moderate and vigorous physical activity scores were associated with lower symptoms of RLS (rs = −0.43 to −0.47). Results from this small study carried out under naturalistic conditions suggest that among PwMS, better objective sleep correlated with better subjective sleep and higher moderate physical activity levels.
The Term Equity in Education: A Literature Review with Scientific Mapping in Web of Science
Authors: Jurado de los Santos Pedro , Moreno-Guerrero Antonio-José , Marín-Marín José-Antonio , Soler Costa Rebeca
Published: May 2020

The term “equity” (EQUI) is a complex concept to be defined, because it depends on many factors, mainly political ideals. The objective of this research is to determine the evolution and development of the term equity in education by the scientific community. The main objective is to identify the scientific production and performance of the term equity in the field of education. The research method developed is based on bibliometrics, specifically on the technique of scientific mapping, and a process of quantification, analysis, evaluation and estimation of scientific documents was developed. The results indicate there is no established line of research or strong connections between the themes. This shows the existing variety of research on the term equity. Thus, the trend in research on the term equity is focused on the early periods of study on the students’ diversity in order to evolve to more concrete and specific aspects of equity, such as gender and race. It is concluded that the theoretical framework of reference shows how equity should be incorporated into the education system under the parameters of equal opportunities, of equality in access to higher education, regardless of gender or socio-cultural background.
Age and Upper Airway Obstruction: A Challenge to the Clinical Approach in Pediatric Patients
Authors: Luana Nosetti , Marco Zaffanello , Francesca De Bernardi , Giorgio Piacentini , Giulia Roberto , Silvia Salvatore , Daniela Simoncini , Angelo Pietrobelli , Massimo Agosti
Published: May 2020

Upper airway abnormalities increase the risk of pediatric morbidity in infants. A multidisciplinary approach to obstructive sleep apnea syndrome (OSAS) poses challenges to clinical practice. The incidence and causes of OSA are poorly studied in children under 2 years of age. To fill this gap, we performed this retrospective observational study to determine the causes of obstructive sleep apnea (OSA) in children admitted to our hospital between January 2016 and February 2018, after a brief unexplained event (BRUE) or for OSA. We reviewed the medical charts of 82 patients (39 males; BRUE n = 48; OSAS n = 34) and divided them into two age groups: < 1 year old (1–12 months; n = 59) and >1 year old (>12–24 months; n = 23). Assessment included nap polysomnography, multichannel intraluminal impedance-pH, and nasopharyngoscopy. Sleep disordered breathing was comparable between the two groups. Omega-shaped epiglottis, laryngomalacia, and nasal septum deviation were more frequent in the younger group, and nasal congestion in older group. Tonsillar and adenoidal hypertrophy was more frequent in the older group, while laryngomalacia and gastroesophageal reflux was more frequent in the younger group. Tonsil and adenoid size were associated with grade of apnea-hypopnea index severity in the older group, and laryngomalacia and gastroesophageal reflux in the younger group. The main causes of respiratory sleep disorders differ in children before or after age 1 year. Our findings have potential clinical utility for assessing the pathophysiology of obstructive sleep disordered breathing in patients less than 2 years old.
Online Resources for People Who Self-Harm and Those Involved in Their Informal and Formal Care: Observational Study with Content Analysis
Authors: Romeu Daniel , Guthrie Elspeth , Brennan Cathy , Farley Kate , House Allan
Published: May 2020

Despite recent fears about online influences on self-harm, the internet has potential to be a useful resource, and people who self-harm commonly use it to seek advice and support. Our aim was to identify and describe UK-generated internet resources for people who self-harm, their friends or families, in an observational study of information available to people who search the internet for help and guidance. The different types of advice from different websites were grouped according to thematic analysis. We found a large amount of advice and guidance regarding the management of self-harm. The most detailed and practical advice, however, was limited to a small number of non-statutory sites. A lay person or health professional who searches the web may have to search through many different websites to find practical help. Our findings therefore provide a useful starting point for clinicians who wish to provide some guidance for their patients about internet use. Websites change over time and the internet is in constant flux, so the websites that we identified would need to be reviewed before making any recommendations to patients or their families or friends.
Water Pricing Policy as Tool to Induce Efficiency in Water Resources Management
Authors: García-López Marcos , Montano Borja , Melgarejo Joaquín
Published: May 2020

This research seeks to determine and analyze the reaction to an increase in the water invoice with the aim of introducing improvements in wastewater treatments. To this end, the purification situation is analyzed and the price elasticities of demand are obtained through Ordinary Minimum Squares. The results show that there are several small noncompliant treatment plants, as well as a complex interaction among consumption, price, and income. In many cases, the results offer small or significant differences without a clear pattern. However, it highlights the number of household members as it is strongly related to consumption and price and not considering it in the elaboration or modification of the water tariff would lead to inefficiencies. A reduction in revenue has also been found due to the strong consumer reaction, so it is necessary to assess in more depth what kind of price change would be most appropriate, as well as whether such measures would be best suited to address the problem.
Overexpression of Melon Tonoplast Sugar Transporter CmTST1 Improved Root Growth under High Sugar Content
Authors: Lu Baiyi , Wen Suying , Zhu Peilu , Cao Haishun , Zhou Yixuan , Bie Zhilong , Cheng Jintao
Published: May 2020

Sugar allocation is based on the source-to-sink and intracellular transport between different organelles, and sugar transporters are usually involved in these processes. Tonoplast sugar transporters (TST) are responsible for transporting sugar into vacuoles; however, the role of TSTs in root growth and the response to abiotic stress is poorly studied. Here, RNA analysis and promoter-β-glucuronidase staining revealed that a melon TST1 gene (CmTST1) is highly expressed in the roots. The sugar feeding experiment results showed that the expression of CmTST1 in the roots was induced by a relatively high level of sucrose (6%), glucose (3%), and fructose (3%). The ectopic overexpression of CmTST1 in Arabidopsis improved the root and shoot growth of seedlings under high exogenous sugar stress. Furthermore, the ectopic expression of CmTST1 promoted the expression of plasma membrane-located sugar transporters. We proposed that CmTST1 plays a key role in importing sugar transport into the vacuoles of roots in response to metabolic demands to maintain cytosolic sugar homeostasis.
Ellagic Acid Controls Cell Proliferation and Induces Apoptosis in Breast Cancer Cells via Inhibition of Cyclin-Dependent Kinase 6
Authors: Yousuf Mohd , Shamsi Anas , Khan Parvez , Shahbaaz Mohd , AlAjmi Mohamed F. , Hussain Afzal , Hassan Gulam Mustafa , Islam Asimul , Rizwanul Haque Qazi Mohd , Hassan Md. Imtaiyaz
Published: May 2020

Cyclin-Dependent Kinase 6 (CDK6) plays an important role in cancer progression, and thus, it is considered as an attractive drug target in anticancer therapeutics. This study presents an evaluation of dietary phytochemicals, capsaicin, tocopherol, rosmarinic acid, ursolic acid, ellagic acid (EA), limonene, caffeic acid, and ferulic acid for their potential to inhibit the activity of CDK6. Molecular docking and fluorescence binding studies revealed appreciable binding affinities of these compounds to the CDK6. Among them, EA shows the highest binding affinity for CDK6, and thus a molecular dynamics simulation study of 200 ns was performed to get deeper insights into the binding mechanism and stability of the CDK6-EA complex. Fluorescence binding studies revealed that EA binds to the CDK6 with a binding constant of K = 107 M−1 and subsequently inhibits its enzyme activity with an IC50 value of 3.053 µM. Analysis of thermodynamic parameters of CDK6-EA complex formation suggested a hydrophobic interaction driven process. The treatment of EA decreases the colonization of cancer cells and induces apoptosis. Moreover, the expression of CDK6 has been downregulated in EA-treated human breast cancer cell lines. In conclusion, this study establishes EA as a potent CDK6 inhibitor that can be further evaluated in CDK6 directed anticancer therapies.
Instability of Non-Standard Microsatellites in Relation to Prognosis in Metastatic Colorectal Cancer Patients
Authors: Pirini Francesca , Pasini Luigi , Tedaldi Gianluca , Scarpi Emanuela , Marisi Giorgia , Molinari Chiara , Calistri Daniele , Passardi Alessandro , Ulivi Paola
Published: May 2020

Very few data are reported in the literature on the association between elevated microsatellite alterations at selected tetranucleotide repeats (EMAST) and prognosis in advanced colorectal cancer. Moreover, there is no information available in relation to the response to antiangiogenic treatment. We analyzed EMAST and vascular endothelial growth factor-B (VEGF-B) microsatellite status, together with standard microsatellite instability (MSI), in relation to prognosis in 141 patients with metastatic colorectal cancer (mCRC) treated with chemotherapy (CT) alone (n = 51) or chemotherapy with bevacizumab (B) (CT + B; n = 90). High MSI (MSI-H) was detected in 3% of patients and was associated with progression-free survival (PFS; p = 0.005) and overall survival (OS; p < 0.0001). A total of 8% of cases showed EMAST instability, which was associated with worse PFS (p = 0.0006) and OS (p < 0.0001) in patients treated with CT + B. A total of 24.2% of patients showed VEGF-B instability associated with poorer outcome in (p = 0.005) in the CT arm. In conclusion, our analysis indicated that EMAST instability is associated with worse prognosis, particularly evident in patients receiving CT + B.
Enhanced Osseointegration and Bio-Decontamination of Nanostructured Titanium Based on Non-Thermal Atmospheric Pressure Plasma
Authors: Zeng Yuhao , Komasa Satoshi , Nishida Hisataka , Agariguchi Akinori , Sekino Tohru , Okazaki Joji
Published: May 2020

Alkali-treated titanate layer with nanonetwork structures (TNS) is a promising surface for improving osseointegration capacity in implants. Nevertheless, there is a risk of device failure as a result of insufficient resistance to biofilm contamination. This study tested whether treatment using a handheld non-thermal plasma device could efficiently eliminate biofilm contamination without destroying the surface nanostructure while re-establishing a surface that promoted new bone generation. TNS specimens were treated by a piezoelectric direct discharge (PDD) plasma generator. The effect of decontamination was performed utilizing Staphylococcus aureus. The evaluation of initial cell attachment with adhesion images, alkaline phosphatase activity, extracellular matrix mineralization, and expression of genes related to osteogenesis was performed using rat bone marrow mesenchymal stem cells, and the bone response were evaluated in vivo using a rat femur model. Nanotopography and surface roughness did not significantly differ before and after plasma treatments. Cell and bone formation activity were improved by TNS plasma treatment. Furthermore, plasma treatment effectively eliminated biofilm contamination from the surface. These results suggested that this plasma treatment may be a promising approach for the treatment of nanomaterials immediately before implantation and a therapeutic strategy for peri-implantitis.
SMAD4 and the TGFβ Pathway in Patients with Pancreatic Ductal Adenocarcinoma
Authors: Dardare Julie , Witz Andréa , Merlin Jean-Louis , Gilson Pauline , Harlé Alexandre
Published: May 2020

Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer death worldwide. PDAC is an aggressive disease with an 11-month median overall survival and a five-year survival of less than 5%. Incidence of PDAC is constantly increasing and is predicted to become the second leading cause of cancer in Western countries within a decade. Despite research and therapeutic development, current knowledge about PDAC molecular mechanisms still needs improvements and it seems crucial to identify novel therapeutic targets. Genomic analyses of PDAC revealed that transforming growth factor β (TGFβ) signaling pathways are modified and the SMAD4 gene is altered in 47% and 60% of cases, respectively, highlighting their major roles in PDAC development. TGFβ can play a dual role in malignancy depending on the context, sometimes as an inhibitor and sometimes as an inducer of tumor progression. TGFβ signaling was identified as a potent inducer of epithelial-to-mesenchymal transition (EMT), a process that confers migratory and invasive properties to epithelial cells during cancer. Therefore, aberrant TGFβ signaling and EMT are linked to promoting PDAC aggressiveness. TGFβ and SMAD pathways were extensively studied but the mechanisms leading to cancer promotion and development still remain unclear. This review aims to describe the complex role of SMAD4 in the TGFβ pathway in patients with PDAC.
Hematological Diseases and Osteoporosis
Authors: Gaudio Agostino , Xourafa Anastasia , Rapisarda Rosario , Zanoli Luca , Signorelli Salvatore Santo , Castellino Pietro
Published: May 2020

Secondary osteoporosis is a common clinical problem faced by bone specialists, with a higher frequency in men than in women. One of several causes of secondary osteoporosis is hematological disease. There are numerous hematological diseases that can have a deleterious impact on bone health. In the literature, there is an abundance of evidence of bone involvement in patients affected by multiple myeloma, systemic mastocytosis, thalassemia, and hemophilia; some skeletal disorders are also reported in sickle cell disease. Recently, monoclonal gammopathy of undetermined significance appears to increase fracture risk, predominantly in male subjects. The pathogenetic mechanisms responsible for these bone loss effects have not yet been completely clarified. Many soluble factors, in particular cytokines that regulate bone metabolism, appear to play an important role. An integrated approach to these hematological diseases, with the help of a bone specialist, could reduce the bone fracture rate and improve the quality of life of these patients.
PHLD Class Proteins: A Family of New Players in the p53 Network
Authors: Fuselier Taylor T. , Lu Hua
Published: May 2020

The Pleckstrin Homology-like Domain (PHLD) class of proteins are multifunctional proteins. The class is comprised of two families of proteins, PHLDA and PHLDB, each with 3 members. All members of the families possess a pleckstrin homology (PH) domain. Though identified nearly 30 years ago, this class of proteins remains understudied with PHLDA family members receiving most of the research attention. Recent studies have also begun to reveal the functions of the PHLDB family proteins in regulation of p53 and AKT signaling pathways important for cancer and metabolism. This review will discuss current research and offer some prospects on the possible roles of both families in cancer and metabolism.
The Role of Lipid Metabolism in COVID-19 Virus Infection and as a Drug Target
Authors: Abu-Farha Mohamed , Thanaraj Thangavel Alphonse , Qaddoumi Mohammad G. , Hashem Anwar , Abubaker Jehad , Al-Mulla Fahd
Published: May 2020

The current Coronavirus disease 2019 or COVID-19 pandemic has infected over two million people and resulted in the death of over one hundred thousand people at the time of writing this review. The disease is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Even though multiple vaccines and treatments are under development so far, the disease is only slowing down under extreme social distancing measures that are difficult to maintain. SARS-COV-2 is an enveloped virus that is surrounded by a lipid bilayer. Lipids are fundamental cell components that play various biological roles ranging from being a structural building block to a signaling molecule as well as a central energy store. The role lipids play in viral infection involves the fusion of the viral membrane to the host cell, viral replication, and viral endocytosis and exocytosis. Since lipids play a crucial function in the viral life cycle, we asked whether drugs targeting lipid metabolism, such as statins, can be utilized against SARS-CoV-2 and other viruses. In this review, we discuss the role of lipid metabolism in viral infection as well as the possibility of targeting lipid metabolism to interfere with the viral life cycle.
New Treatments in Renal Cancer: The AhR Ligands
Authors: Itkin Boris , Breen Alastair , Turyanska Lyudmila , Sandes Eduardo Omar , Bradshaw Tracey D. , Loaiza-Perez Andrea Irene
Published: May 2020

Kidney cancer rapidly acquires resistance to antiangiogenic agents, such as sunitinib, developing an aggressive migratory phenotype (facilitated by c-Metsignal transduction). The Aryl hydrocarbon receptor (AhR) has recently been postulated as a molecular target for cancer treatment. Currently, there are two antitumor agent AhR ligands, with activity against renal cancer, that have been tested clinically: aminoflavone (AFP 464, NSC710464) and the benzothiazole (5F 203) prodrug Phortress. Our studies investigated the action of AFP 464, the aminoflavone pro-drug currently used in clinical trials, and 5F 203 on renal cancer cells, specifically examining their effects on cell cycle progression, apoptosis and cell migration. Both compounds caused cell cycle arrest and apoptosis but only 5F 203 potently inhibited the migration of TK-10, Caki-1 and SN12C cells as well as the migration signal transduction cascade, involving c-Met signaling, in TK-10 cells. Current investigations are focused on the development of nano-delivery vehicles, apoferritin-encapsulated benzothiazoles 5F 203 and GW610, for the treatment of renal cancer. These compounds have shown improved antitumor effects against TK-10 cells in vitro at lower concentrations compared with a naked agent.
Genetic Susceptibility to Chronic Liver Disease in Individuals from Pakistan
Authors: Raja Asad , Ciociola Ester , Ahmad Imran , Dar Faisal , Naqvi Syed , Moaeen-ud-Din Muhammad , Raja Ghazala , Romeo Stefano , Mancina Rosellina
Published: May 2020

Chronic liver disease, with viral or non-viral etiology, is endemic in many countries and is a growing burden in Asia. Among the Asian countries, Pakistan has the highest prevalence of chronic liver disease. Despite this, the genetic susceptibility to chronic liver disease in this country has not been investigated. We performed a comprehensive analysis of the most robustly associated common genetic variants influencing chronic liver disease in a cohort of individuals from Pakistan. A total of 587 subjects with chronic liver disease and 68 healthy control individuals were genotyped for the HSD17B13 rs7261356, MBOAT7 rs641738, GCKR rs1260326, PNPLA3 rs738409, TM6SF2 rs58542926 and PPP1R3B rs4841132 variants. The variants distribution between case and control group and their association with chronic liver disease were tested by chi-square and binary logistic analysis, respectively. We report for the first time that HSD17B13 variant results in a 50% reduced risk for chronic liver disease; while MBOAT7; GCKR and PNPLA3 variants increase this risk by more than 35% in Pakistani individuals. Our genetic analysis extends the protective role of the HSD17B13 variant against chronic liver disease and disease risk conferred by the MBOAT7; GCKR and PNPLA3 variants in the Pakistani population.