bluuebunny/crossref_metadata_2025 huggingface dataset:
Glutamine antagonist DRP-104 in combination with durvalumab in patients with advanced fibrolamellar carcinoma (FLC) following progression on prior anti-PD(L)1 therapy.
Authors: Nakazawa Mari , Kamdar Zeal , Thomas Amy , Durham Jennifer N. , Nauroth Julie , Wang Hao , Ladle Brian H. , Dykstra Steven , Dugan Margaret , Lafleur Francois , Furth Mark E. , Leone Robert D. , Jaffee Elizabeth M. , Yarchoan Mark , Baretti Marina
Published: January 2024

TPS573

Background: Fibrolamellar carcinoma (FLC) is a rare, aggressive form of primary liver cancer predominantly affecting children and young adults under the age of 30. There is no established standard therapy and most patients with advanced disease succumb to their illness with a median prognosis of only 12 months. A chimeric transcript between DNAJB1 and PRKACA, which encodes the catalytic subunit of protein kinase A (PKA), was identified as a signature genomic event in FLC. However, pharmacological inhibition of PKAc for FLC with traditional small molecule inhibitors has been infeasible due to unacceptable on-target toxicity. Preclinical work from our laboratory and others has revealed that the DNAJB1- PRKACA fusion results in a metabolic rewiring of the tumor characterized by glutamine dependence. This glutamine dependence also creates a nutrient-depleted tumor immune microenvironment (TiME) enriched in immunosuppressive metabolites (e.g., ammonia, acidosis) that prohibits an effective antitumor immune response. Through this trial, we will test the hypothesis that glutamine antagonism in FLC reverses resistance to immune checkpoint inhibitor (ICI) therapy through modulating the TiME. Methods: We are conducting a single-arm phase 1b/2 clinical trial of glutamine antagonist DRP-104 in combination with durvalumab in children (age ≥ 12) and adults with advanced FLC who have progressed on prior anti-PD(L)1 therapy. Patients will receive DRP-104 (145 mg s.c. twice weekly) in combination with a fixed dose of durvalumab (1500 mg i.v. every 28 days). The primary clinical endpoints are safety and objective response rate (ORR), defined as the percentage of patients achieving a complete response (CR) or partial response (PR) based on the Response Evaluation Criteria in Solid Tumors (RECIST 1.1). Secondary objectives include progression free survival (PFS), overall survival (OS), and immunological correlates. Key eligibility criteria include histologically confirmed FLC that is metastatic or unresectable; demonstrated radiographic progression on at least one line of prior anti-PD(L)1 therapy; Age ≥ 12 years; ECOG performance status of ≤2; measurable disease according to RECIST 1.1; and adequate end organ function. Patients will undergo fresh core tumor biopsy pre-treatment and at approximately week 4. Biopsies will be used to prepare paraffin embedded and flash-frozen samples. Research bloodwork will be collected prior to dosing at baseline, prior to dosing on cycles 2-5, and every 3 months thereafter to be processed for PBMC isolation. This study has been registered under NCT06027086 and is expected to begin enrollment in December 2023. Clinical trial information: NCT06027086 .
A phase II study to evaluate the safety and efficacy of anlotinib combined with penpulimab for advanced refractory biliary tract cancer.
Authors: He Xiaojun , Tan Kai , Du Xilin
Published: January 2024

TPS582

Background: Although with modest efficacy, mFOLFOX is recommended as standard second-line chemotherapy for advanced biliary tract cancer (BTC). Several clinical trials are exploring the combination treatment of antiangiogenic drugs and immune checkpoint inhibitors. Anlotinib is an oral multi-targeted tyrosine kinase inhibitor targeting VEGFR1/2/3, FGFR1-4 and PDGFRα/β, which effectively blocks tumor neovascularization and growth. Previous phase I/II clinical trials suggested that anlotinib combined with PD-(L)1 inhibitors as second-line therapy was well tolerated and showed clinical anti-tumor activity in advanced biliary tract cancer (NCT03825705, NCT03996408, ChiCTR1900022003, ChiCTR2000037847). Penpulimab is a novel humanized anti-PD-1 IgG1 antibody with complete removal of Fc receptor mediated effect, and featuring slow antigen binding off-rate and high receptor occupancy. In this study, we explore anlotinib plus penpulimab as a chemo-free combination for second-line and above therapy. Methods: This is a prospective, single-arm, phase II study. BTC patients (pts) failed after the first-line treatment, aged 18-75 and an ECOG PS of 0-1 were recruited.Eligible pts received anlotinib (12mg, po, d1-14, q3w) and penpulimab (200mg, iv, d1, q3w) until disease progression, unacceptable toxicity or up to 2 years. The primary endpoint was Objective Response Rate (ORR). Secondary endpoints included Overall survival (OS), Progression-Free Survival (PFS), Disease Control Rate (DCR) and safety. Based on a two-sided test for one proportion with 5.0% type I error, 80% power to detect an improvement in ORR from 5% to 22%, there will be 27 pts enrolled considering 20% of pts dropping out. Clinical trial information: ChiCTR2300069126 .
PRECISION 1: A phase 2, multicenter, open-label basket trial of nab-sirolimus for malignant solid tumors harboring pathogenic inactivating alterations in TSC1 and TSC2.
Authors: Deming Dustin A. , Kwiatkowski David J. , Ding Li , Schmid Anita N. , Navarro Willis H. , Rodon Ahnert Jordi , Iyer Gopa
Published: January 2024

TPS585

Background: SEER data report that US patients with advanced gastrointestinal (GI) cancers have a poor prognosis as indicated by low 5-year survival rates in patients with colorectal (15.6%), liver (3.5%), and other GI cancers, highlighting the need for more efficacious treatments. Dysregulation of the mTOR pathway contributes to tumor growth and disease progression in many cancers, including GI cancers. The tumor suppressor genes TSC1 and TSC2 are critical negative regulators of mTOR activity whose inactivation can lead to tumor cell growth. Inactivating TSC1 and TSC2 alterations have been observed in GI cancers with a combined frequency of up to 6.5% in hepatocellular carcinoma, 1.7% in colorectal adenocarcinoma and gastrointestinal stromal tumors, and 1.6% in cholangiocarcinoma. nab-Sirolimus, approved in the US for patients with advanced malignant perivascular epithelioid cell tumor (PEComa), is an albumin-bound mTOR inhibitor (mTORi) that inhibits the mTOR pathway via suppression of the mTORC1 complex. In an exploratory analysis of the pivotal AMPECT trial of nab-sirolimus in advanced malignant PEComa (NCT02494570), 8/9 (89%) and 1/5 (20%) patients with inactivating alterations in TSC2 and TSC1, respectively, had a confirmed response. Most treatment-related adverse events were grade 1/2 (none were grade ≥4) and were consistent with mTORi-class adverse events. Based on the clinical observations from AMPECT and the underlying mechanism of action of nab-sirolimus, the PRECISION 1 trial was designed to assess the safety and efficacy of nab-sirolimus in a tumor-agnostic study of patients with advanced cancers harboring TSC1 or TSC2 inactivating alterations. The trial is open to patients with GI cancers with inactivating alterations in TSC1 or TSC2. Methods: In PRECISION 1 (NCT05103358), eligible patients are ≥12 years old and mTORi-naïve, have advanced malignant solid tumors harboring TSC1 or TSC2 inactivating alterations identified using next-generation sequencing (NGS) of tumor tissue or liquid biopsy (confirmed by central review of NGS reports), and have received appropriate standard treatments, per investigator. nab-Sirolimus 100 mg/m2 is given intravenously over 30 min on days 1 and 8 of each 21-day cycle. The primary endpoint is overall response rate per independent radiographic review (IRR) using Response Evaluation Criteria in Solid Tumors v1.1. Other endpoints include duration of response, time to response, progression-free survival by IRR, overall survival, patient-reported quality of life, and safety. Enrollment began in March 2022. Collaboration with leading NGS vendors is expediting the identification of patients with qualifying TSC1 and TSC2 alterations; ongoing study access is facilitated through a just-in-time approach to trial location activation. Clinical trial information: NCT05103358 .
Peak study: A phase 3, randomized, open-label multicenter clinical study of bezuclastinib (CGT9486) and sunitinib in combination versus sunitinib in patients with gastrointestinal stromal tumors (GIST).
Authors: Heinrich Michael C. , Somaiah Neeta , Trent Jonathan C. , Wilky Breelyn A. , Burgess Melissa Amber , Singh Arun S. , Attia Steven , Agulnik Mark , Tap William D. , Bauer Sebastian , Jones Robin Lewis , Serrano Cesar , Zou Liangxing , Moynihan Kevin , Lawrence Julia , Wagner Andrew J.
Published: January 2024

TPS766

Background: Imatinib is the worldwide standard for first-line therapy of advanced KIT-mutant GIST. However, secondary resistance mutations in the KIT ATP-binding domain (exons 13, 14), activation loop (exons 17, 18), or both develop and result in loss of imatinib-sensitivity. While no single tyrosine kinase inhibitor (TKI) inhibits all KIT mutations, the combination of bezuclastinib + sunitinib targets commonly occurring primary (exons 9, 11) and secondary (exons 13, 14, 17, and 18) KIT mutations. In a Phase 1/2 clinical study, pts with relapsed and/or refractory GIST and a median of 3 prior lines of therapy treated with bezuclastinib + sunitinib (n=15) experienced clinical benefit and an acceptable safety profile, warranting further evaluation in a randomized trial. Methods: Peak (NCT05208047) is a global, randomized, open-label, multi-part Phase 3 study evaluating the efficacy and safety of bezuclastinib + sunitinib versus sunitinib as second-line treatment in adult pts who were intolerant to imatinib or whose tumors had imatinib-resistance. The lead-in portion, to test a new formulation of bezuclastinib, (Part 1) has completed enrollment. Based upon PK and safety, a dose of bezuclastinib 600 mg QD + sunitinib 37.5 mg QD has been determined for Part 2 of the Peak study. Part 2 will enroll ~388 pts to be randomized (1:1) to bezuclastinib 600 mg QD + sunitinib 37.5 mg QD or sunitinib 37.5 mg QD alone. Key inclusion: >1 measurable lesion per modified Response Evaluation Criteria in Solid Tumors (mRECIST) v1.1, Eastern Cooperative Oncology Group Performance Status 0-2, adequate organ function, and prior imatinib therapy (no other prior therapy). Key exclusion: PDGFR mutations or succinate dehydrogenase deficiency, clinically significant cardiac disease, and use of strong CYP3A4 inhibitors or inducers. The primary endpoint is progression-free survival (PFS) confirmed by blinded independent central review per mRECIST v1.1. Additional efficacy (including overall survival and objective response rate) and safety endpoints will be evaluated. Clinical trial information: NCT05208047 .
Controlled expression of avian pre-migratory fattening influences indices of innate immunity
Authors: Tobolka Marcin , Zielińska Zuzanna , Fusani Leonida , Huber Nikolaus , Maggini Ivan , Pola Gianni , Marasco Valeria
Published: January 2024

While immunity is frequently dampened when birds engage in strenuous migratory flights, whether and how immunity changes during the rapid accumulation of energy stores in preparation for migration remains largely unknown. Here we induced pre-migratory fattening through controlled changes of daylight in common quails (Coturnix coturnix) and regularly assessed changes in three markers of constitutive innate immunity (leukocyte coping capacity or LCC, hemagglutination and hemolysis titres) and measures of body composition (lean and fat mass). All the three markers showed similar changes over the pre-migratory fattening process. LCC responses, hemagglutination titres, and hemolysis titres, were on average higher in the mid-fattening phase compared to the peak-fattening phase, when values were similar to those observed prior the start of pre-migratory fattening. At mid-fattening, we found that the birds that showed a larger accumulation of fat mass (as % of body mass) had lower LCC peak responses and hemolysis titres. Reversibly, at mid-fattening, we also found that the birds that kept a higher proportion of lean mass (as % of body mass) had the highest LCC peaks. Our results indicate that migratory birds undergo changes in immune indices (over 8 weeks) as they accumulate energy stores for migration and propose that this could be due to competing or trade-off processes between metabolic remodelling and innate immune system function.
There's just nothing stable anymore
Authors: Θεοδωρίδης Κωνσταντίνος
Published: January 2024

Η παρούσα διδακτορική διατριβή διερευνά τη σχέση μεταξύ των νεανικών ταυτοτήτων και της κατανάλωσης των μέσων κοινωνικής δικτύωσης σε μια περίοδο οικονομικής κρίσης. Η έρευνα έχει σχεδιαστεί για να εξετάσει τον ρόλο της επωνυμοποίησης του εαυτού (self-branding) στη σχέση των νέων με την κατανάλωση και τη σημασία της για την έννοια του εαυτού σε έναν ψηφιακό κόσμο. Η διατριβή μελετά σε βάθος τους κοινωνικούς μετασχηματισμούς που αναδύονται σε έναν αβέβαιο κόσμο μέσω μιας συγκριτικής έρευνας μεταξύ Ελλάδας και Ηνωμένου Βασιλείου, εστιάζοντας στην κατανάλωση των μέσων κοινωνικής δικτύωσης από νέους και νέες των ηλικιών από δεκαέξι έως τριάντα ετών. Η έρευνα στηρίζεται στην ποιοτική μέθοδο με τη χρήση τριγωνοποίησης που βασίζεται σε πρωτογενή δεδομένα τα οποία συλλέχθηκαν σε τρία ερευνητικά στάδια. Πιο αναλυτικά, η συλλογή των δεδομένων περιελάμβανε: ομάδες εστίασης, συνεντεύξεις με τη χρήση φωτογραφιών και μια περίοδο παρατήρησης της χρήσης του Instagram από τους νέους και τις νέες. Τα δεδομένα υποδεικνύουν ότι οι νέοι και οι νέες αναζητούν μια διέξοδο από την καθημερινή ζωή που έχει πληγεί από τη Διεθνή Χρηματοπιστωτική Κρίση μέσω είτε της μετανάστευσης στο εξωτερικό είτε της απόδρασης στον ψηφιακό κόσμο ευελπιστώντας στην ανακάλυψη μιας καλύτερης ζωής. Η διατριβή εστιάζει στις πρακτικές επωνυμοποίησης (branding) τις οποίες υιοθετούν οι νέοι και οι νέες στο διαδίκτυο, καθώς ανταγωνίζονται σε αυτό το νέο εμπορευματοποιημένο χώρο. Η μελέτη υποστηρίζει ότι τα μέσα κοινωνικής δικτύωσης παρέχουν στη νεολαία ένα βασικό μέσο με το οποίο μπορούν να διαμορφώσουν τις ταυτότητές τους, την ίδια στιγμή που με αυτό τον τρόπο δημιουργούν ένα περιβάλλον επιμέλειας των διαδικτυακών προφίλ τους. Η διατριβή συζητά τις επιπτώσεις της σχέσης μεταξύ της οικονομικής αστάθειας, των μέσων κοινωνικής δικτύωσης και των νεανικών ταυτοτήτων. Πιο συγκεκριμένα, ενδιαφέρεται για τη συνάρθρωση της παραγωγής με την κατανάλωση μιας ψηφιακά επαυξημένης "μάρκας" (brand) του εαυτού που είναι ουσιαστικά εφήμερη. Τέλος, αναστοχάζεται την κοινωνιολογική σημασία της κατανάλωσης των μέσων κοινωνικής δικτύωσης ως επιτελεστικού χώρου μέσα στον οποίο οι νέοι και οι νέες μπορούν να διεκδικήσουν μια συνεκτική αίσθηση ταυτότητας ενώ παράλληλα ενσωματώνονται στην καταναλωτική κοινωνία η οποία τους ωθεί σχεδόν καταναγκαστικά σε αυτή τη διαδικασία.
Computational design of metal nanoparticles for energy applications
Authors: Περβολαράκης Εμμανουήλ
Published: January 2024

Η ανάγκη να στραφούμε σε ανανεώσιμε πηγές ενέργειες είναι πιο επιτακτική από ποτέ, συνεπώς είναι ύψιστης σημασίας η βελτίωση της απόδοσης και η μείωση του κόστους των ήδη υπαρχουσών τεχνολογιών, κάτι το οποίο μπορεί να επιταχυνθεί μέσω του υπολογιστικού σχεδιασμού των υλικών. Στην παρούσα διδακτορική διατριβή χρησιμοποιούμε υπολογισμούς θεωρίας συναρτησιακού πυκνότητας (DFT) και στατιστικές μεθόδους όπως μηχανική μάθηση για την διερεύνηση διαφόρων ζητημάτων σχεδιασμού υλικών σε εφαρμογές ενέργειας. Το πρώτο από αυτά τα ζητήματα αφορά την πρόβλεψη του σχήματος ισορροπίας μικρών νανοσωματιδίων χρυσού και ο καθορισμός του ορίου των συμβατικών μεθόδων που χρησιμοποιούνται έως σήμερα για αυτό. Η μέθοδος κατασκευής Wulff που είναι το σύνηθες εργαλείο για την πρόβλεψη του σχήματος νανοσωματιδίων, θα επεκταθεί ώστε να λαμβάνει υπόψιν της τις ενέργειες των ακμών, που κανονικά αγνοεί, πέραν των επιφανειακών τάσεων του υλικού. Οι ενέργειες των ακμών καθορίστηκαν με ανάλυση, μέσω μηχανικής μάθησης, μιας βάσης δεδομένων από υπολογισμένες ολικές ενέργειες για διάφορες νανοδομές. Σε αυτό το πλαίσιο θα συζητηθούν και οι οπτικές ιδιότητες του χρυσού που επηρεάζονται από το σχήμα. Για το τελευταίο κομμάτι της διατριβής, τρεις άλλες κατηγορίες υλικών ερευνήθηκαν, κατηγορίες με ενδιαφέρον για εφαρμογές ενέργειας και περιβάλλοντος και πιο συγκεκριμένα κράματα υψηλής εντροπίας, κράματα οξειδίων του μαγγανίου και περοβσκίτες αλογόνων. Πιο συγκεκριμένα, εστιαζόμαστε στην προσρόφηση OH σε επιφάνειες του κράματος υψηλής εντροπίας CoCuFeNiPt, στη σταθερότητα και τα ενεργειακά χάσματα των οξειδίων Zn-Mn-Ni στις δομές χαουσμανίτη και σπινελίου και τέλος σε ένα εργαλείο μηχανικής μάθησης που μπορεί με ακρίβεια να προβλέπει τα ενεργειακά χάσματα των περοβσκιτών αλογόνων. Συνεπώς, συνδυάζοντας διάφορα επίπεδα θεωρίας, από κβαντομηχανικούς υπολογισμούς έως επιστήμη δεδομένων και μηχανική μάθηση, μπορούμε να προσφέρουμε χρήσιμες πληροφορίες για τους μηχανισμούς που διέπουν την απόδοση των νανοϋλικών σε εφαρμογές ενέργειας.
Movement strategy identification in activities of daily living
Authors: Κόμαρης Δημήτριος-Σωκράτης
Published: January 2024

Εισαγωγή: Η οστεοαρθρίτιδα είναι μια από τις κύριες αιτίες αναπηρίας και η άρθρωση του γόνατος είναι η πιο συχνά προσβεβλημένη περιοχή στο σώμα. Η τελευταία λύση για τη θεραπεία της οστεοαρθρίτιδας του γόνατος τελικού σταδίου είναι η χειρουργική επέμβαση ολικής αρθροπλαστικής γόνατος. Παρά την πληθώρα σχεδίων εμφυτευμάτων, τα τρέχοντα στοιχεία για τα οποία τα μοσχεύματα δίνουν την πιο φυσική κίνηση και λειτουργία είναι ακόμα ελάχιστα. Στόχοι: Σκοπός της παρούσας μελέτης ήταν η σύγκριση της λειτουργικής απόδοσης σταθερών και κινητών μοσχευμάτων, με διαφορετικούς βαθμούς συνάφειας. Μέθοδοι: οι συμμετέχοντες εκπαιδεύτηκαν σε τρισδιάστατη ανάλυση καταγραφής κίνησης κατά τη διάρκεια δύο δραστηριοτήτων της καθημερινής ζωής. Οι συμμετέχοντες ασθενείς καταγράφηκαν πριν, τέσσερις έως έξι εβδομάδες μετά και ένα χρόνο μετά την επέμβαση. Τα επίπεδα πόνου και ικανοποίησης ερευνήθηκαν επίσης χρησιμοποιώντας ερωτηματολόγια. Η λειτουργική απόδοση των συμμετεχόντων ήταν προσβάσιμη μέσω μιας καινοτόμου στατιστικής διαδικασίας (ιεραρχικής ομαδοποίησης), που ταξινόμησε γόνιμα τα μοτίβα κίνησης και διέκρινε υγιείς από ανθυγιεινές κινητικές συμπεριφορές. Αποτελέσματα: οι συμμετέχοντες με οστεοαρθρίτιδα χρησιμοποίησαν διαφορετικές στρατηγικές κίνησης σε σύγκριση με υγιή άτομα. Η συμπεριφορά των χεριών και των ποδιών των ασθενών κατηγοριοποιήθηκε συχνά ως ασύμμετρη, υποδεικνύοντας την παρουσία μηχανισμών αντιστάθμισης λόγω αδυναμίας της προσβεβλημένης άρθρωσης. Η μετεγχειρητική συμπεριφορά τείνει να συγκλίνει με την απόδοση των υγειών ατόμων. Δεν παρατηρήθηκαν διαφορές λόγω κατανομής εμφυτεύματος γόνατος ή ανθρωπομετρικών χαρακτηριστικών. Η ανάλυση του ερωτηματολογίου αποκάλυψε σημαντική βελτίωση μετεγχειρητικά στην αυτοαξιολόγηση των συμμετεχόντων ασθενών, αλλά χωρίς σημαντική συσχέτιση μεταξύ του σχεδιασμού του εμφυτεύματος και των μέτρων έκβασης. Συμπέρασμα: η προτεινόμενη διαδικασία ιεραρχικής ομαδοποίησης κατάφερε να αξιολογήσει επαρκώς, γρήγορα και αξιόπιστα τις αλλαγές στις κινητικές συνήθειες των ασθενών μετά από ολική αρθροπλαστική γόνατος και να έχει πρόσβαση στη βελτίωσή τους καθ' όλη τη διάρκεια της διαδικασίας αποκατάστασής τους.
Effects of the addition of flower honey and pine honey to extenders on spermatological characteristics in ram semen
Authors: Yüksel H , Eser A , Arıcı R , Yağcıoğlu S , Ak K
Published: January 2024

Bu çalışmada, belirli oranlarda çiçek ve çam balının koç spermatının spermatolojik parametreleri üzerine etkileri araştırılmıştır. Tris-yumurta sarısı bazlı meni sulandırıcıya her bal türü için %1.0 (h/h) ve %2.5 (h/h) oranlarında çiçek ve çam balı eklenmiştir. Sperm toplama için beş Kıvircik koç kullanıldı. Toplanan spermler havuzlamanın ardından 5 eşit parçaya bölündü. %1.0 (h/h) ve %2.5 (h/v) çam balı ve %1.0 (h/v) ve %2.5 (h/h) çiçek balı oranlarında ve bal ilavesi yapılmadan iki aşamalı seyreltme yöntemi kullanılmıştır. Tris-yumurta sarısı bazlı meni genişleticiye. Numuneler daha sonra sıvı nitrojen buharında dondu ve sıvı nitrojen içinde saklandı. Semen canlılığı parametreleri (toplam ve progresif motilite, hız, kinetik hareket parametreleri ve mitokondriyal aktivite) ve morfolojik bütünlük parametreleri (Hancock fiksasyon testi, akış sitometrisi ve floresan boyama) dengeleme ve çözdürmeden sonra değerlendirildi. Çalışma boyunca on tekrarlı çalışma yapılmıştır.Sonuçlar çiçek balının çözülme sonrası canlılık parametreleri üzerinde özellikle %2,5 (h/h) oranında faydalı etkiye sahip olduğunu göstermiştir. Her oranda ve her çeşit bal içeren sulandırıcılar, çözüldükten sonra zar bütünlüğünü korumuştur. Tris-yumurta sarısı bazlı sulandırıcıya %1.0 (v/v) çiçek balı ilavesi, diğer gruplara kıyasla Hancock fiksasyon testi ile akrozomal bütünlük açısından daha iyi sonuçlar vermiştir (p < 0.05). Sonuç olarak, Tris-yumurta sarısı sulandırıcısına %1.0 (h/h) ve %2.5 (h/v) çiçek balı ilavesiyle çözülme sonrası spermatolojik parametrelerde daha iyi sonuçlar kaydedildi.
In vitro evaluation of a natural food supplement as inhibitors of feline herpesvirus replication
Authors: Pacini MI , Bonaccini P , Mazzei M , Forzan M
Published: January 2024

The feline herpesvirus (FHV) is a widely diffused and highly contagious virus that represents a common health problem in cats. It is frequently associated with diseases of different pathogenicity that can be particularly severe in young kittens determining viral pneumonia and sometimes, death. Unfortunately, there isn’t a well-defined therapeutic protocol against the virus. Several studies concerning the application of alternative treatments against herpesviruses have been performed with promising results, in both human and veterinary medicine. The present study aims to investigate in vitro antiviral effects against FHV of the commercially compound HELP-TH1 (Camon, S.p.A., Italy) mainly composed by Ganoderma lucidum, Cordyceps sinensis, and Trametes versicolor. The antiviral effect of HELP-TH1 was evaluated by the Plaque Reduction Assay and by the real time PCR quantifying and comparing the viral load of infected controls vs treated experimental samples. Our data indicate that HELP-TH1 inhibits the cytopathic effect of the virus and reduces the viral load in the experimental conditions demonstrating its antiviral effect.
Survey of antibodies to Peste des petits ruminants virus in small ruminants in the Mediterranean Region of Turkey
Authors: Şevik M
Published: January 2024

Peste des petits ruminants (PPR) is a viral disease affecting sheep and goats caused by peste des petits ruminants virus (PPRV) has a serious economic impact due to the restrictions on animal trade and animal movements and high mortality rates in small ruminant populations. The common clinical sings of the PPR are fever, muco-purulent nasal discharge, diarrhoea and abortion. Seroepidemiological studies of PPRV infection in sheep and goats in Turkey are scant. Therefore, this study was aimed to evaluate the seroprevalence of PPR in small ruminants in Turkey. Ovine blood samples were collected by random sampling method from sheep (n = 77) and goats (n = 61) from unvaccinated flocks (n = 40) in the Antalya Province in the Mediterranean region of Turkey. A competitive enzyme-linked immunosorbent assay (c-ELISA) kit was used to detect antibodies against PPRV in sera samples. Out of 138 sera samples analysed, eighteen sera samples (13%, 95% CI: 7.4 - 18.7) were PPRV seropositive, of which 18.2% (95% CI: 9.6 - 26.8; 14/77) were from sheep, whereas 6.6% (95% CI: 0.3 - 12.8; 4/61) were from goats. Although PPRV seropositivity rate was higher in sheep than goats, it was not statistically significant (P = 0.07). PPRV seropositivity was higher in small ruminants older than 24 months (19.4%) compared with less than or equal to 24 months (7%) (P = 0.04).  Although, there was no statistically significant difference between sexes, PPRV seropositivity rate was higher (14.5%) in females than males (10.9%) (P = 0.61). The flock-level seroprevalence was 30% (12/40). The result of the present study showed that seroprevalence of PPRV infection is high in sheep and goats in the Antalya Province.  However, results of the study are not enough to determine the regional and country-based profile of the PPRV infection in Turkey. Further epidemiological studies are required to get more epidemiology data on PPR in Turkey.
Effects of Bacillus subtilis on the immune parameters, intestinal morphology and mucin gene expression in broilers exposed to Salmonella enterica challenge
Authors: Jouybari MG , Sadeghi AA , Jouzani GS , Chamani M , Aminafshar M
Published: January 2024

The objective of this study was to evaluate the effect of the probiotic Bacillus subtilis supplementation on bacterial population, morphometry and mucin gene expression of intestine, and on immune response in Salmonella challenged broilers. Treatments were: 1) negative control (no probiotic- no challenging); 2) probiotic treated (no challenging); 3) positive control (no probiotic-salmonella challenging), and 4) Salmonella challenged chicks fed probiotic. Salmonella infection resulted in significant decrease in the relative weight of thymus. In challenged birds, dietary addition of probiotic increased (P<0.0.5) the relative weights of bursa and thymus. Population of lactic acid bacteria was significantly higher in probiotic treated groups as compared to negative control or challenged chickens. Challenged chickens had the lowest count of goblet cells and those received probiotic had the highest goblet cells count. The expression of mucin 2 gene was higher in group received dietary probiotic as compared with other treatments. Difference for gene expression was not found in challenged chickens and the negative control (P>0.05). In conclusion, the dietary inclusion of Bacillus subtilis could alleviate the negative effects of Salmonella infection on intestinal cells and bacterial population and could improve the growth and development of immune organs and function in infected broilers.
Presence of genes encoding aminoglycoside-modifying enzyme (AME) and virulence factors in high-level aminoglycoside-resistant (HLAR) Enterococcus strains isolated from retail chicken meat in Turkey
Authors: Yalçın M , Özden Tuncer B , Akpınar Kankaya D , Tuncer Y
Published: January 2024

In this study, the presence of aminoglycoside-modifying enzyme (AME) and virulence factor genes were investigated in previously isolated 32 high-level aminoglycoside-resistant (HLAR) Enterococcus strains isolated from retail chicken meat in Turkey. At least one AME-encoding gene was detected in HLAR enterococci by polymerase chain reaction (PCR). The ant(6ʹ)-Ia was identified as the most prevalent (87.5%, 28/32) AME gene. The aph(3ʹ)-IIIa (78.13%, 25/32), ant(4ʹ)-Ia (68.75%, 22/32), aph(2ʹʹ)-Ib (62.5%, 20/32), aac(6ʹ)-Ie-aph(2ʹʹ)-Ia (21.88%, 7/32) and aph(2ʹʹ)-Ic (9.38%, 3/32) are the other detected AME-encoding genes in strains. The aph(2ʹʹ)-Id was found in none of the HLAR strains. The aph(2ʹʹ)-Ib and ant(6ʹ)-Ia were identified as the most frequently AME-encoding genes in high-level gentamicin-resistant (HLGR) and high-level streptomycin-resistant (HLSR) strains, respectively. Among the 32 HLAR strains, only E. faecalis MSE61.1 and E. avium MSE63.1 were found capable of hydrolyzing gelatine. All HLAR strains showed α-hemolytic activity except E. durans MG13.4 and E. casseliflavus MGM111.1, which were exhibited β- and γ-hemolytic activity, respectively.  It was determined that all HLAR strains, except E. durans MGE13.1 and MGE63.1, contain at least one virulence factor gene. The efaAfm (87.5%, 28/32), acm (65.63%, 21/32) and gelE (37.5%, 12/32) were found to be the most prevalent virulence factor genes. HLAR enterococci strains that have the virulence factor genes may pose a risk to consumer health.
Effects of Suaeda rigida extract on the growth performance, antioxidant capacity and immune function of Karakul sheep
Authors: Sha A , Liu Y , Hao H
Published: January 2024

The objectives of this study were to investigate the effects of dietary supplementation of Suaeda rigida extract on the growth performance, antioxidant capacity and immune function of Karakul sheep. Blood samples were collected from the jugular veins before morning feeding on the 10th, 20th and 30th days of the trial period, respectively, and the serum antioxidant and immune indexes of Karakul sheep in the control and experimental groups were determined. The results showed that the growth performance of Karakul sheep was dramatically improved by dietary supplementation of Suaeda rigida, the contents of NO, cGMP, MDA, H2O2, •OH and the activities of XOD, GGT, NOS in the serums of Karakul sheep were inhibited to varying degrees,  the GSH content and the activities of GSH-Px, GST, CAT and SOD were substantially increased (P<0.05 at 10d, P<0.01 both 20d and 30d). At 30 days, the contents of total protein, globulin, calcium and three immunoglobulins including IgG, IgA, IgM in the sera of experimental Karakul sheep were significantly higher than those in the control group (P<0.05). All the results suggested that the growth performance, antioxidant, anti-aging capacity, immune function, and life extension of Karakul sheep were significantly improved by dietary supplementation with Suaeda rigida.
Effect of alpelisib, a selective phosphatidylinositol-3-kinase inhibitor, on seizure development in a rat pentylenetetrazole model
Authors: Rostamkhani A , Mirazi N , Hosseini A
Published: January 2024

Epilepsy is a neurological disease that results from an abnormality in the brain's activity. Phosphatidylinositol-3-kinase (PI3K) signaling pathway has played a crucial role in epilepsy pathogenesis. Alpelisib (ALP) is a selective inhibitor of PI3K. We examined the ability of ALP to treat pentylenetetrazole (PTZ)-induced convulsions in a rat model. Male Wistar rats (200-250 g, 8 weeks old) were injected intraperitoneally (IP) with ALP at different doses of 15 and 30 mg/kg, or vehicle 30 min prior to PTZ (70 mg/kg, IP) treatment. Racine's scale was used to assess behavioral seizures. The results showed that pretreatment with ALP decreased the seizure stages according to the Racine scale, significantly prolonged the duration of general tonic-clonic seizure (GTCS) and reduced the number of myoclonic jerks (P < 0.05). In conclusion, based on results it was shown that PI3K antagonist ALP inhibited PTZ-induced seizure by inhibiting the PI3K signaling pathway via ALP.
sTREM-1, MR-Pro-Adrenomedullin, clinical biochemistry and hematology in calves with neonatal sepsis
Authors: Sezer M , Gökce G
Published: January 2024

This study aimed to determine the changes in biochemical and hematological parameters and the expression of soluble triggering receptor expressed on myeloid cells-1 (sTREM 1) and mid-regional-pro-adrenomedullin (MR-Pro-ADM) on myeloid cells during treatment in calves with neonatal sepsis. The study group comprised 21 calves, aged 1–16 days, that fit the sepsis criteria. The control group comprised 10 healthy calves of the same age. The clinical examinations of the calves in the study group were performed at certain hours before the treatment (hour 0) and during the treatment (12th, 24th, 48th, and 72nd hours). The blood samples were taken from the vena jugularis before and during treatment from the sick calves and once from the healthy calves. The sTREM-1 levels before treatment (0 h), during treatment (12th, 24th, 48th, and 72nd hours) and control group was follows 59.17±2.58 ng/L, 57.07±1.65 ng/L, 57.27±2.07 ng/L, 56.64±1.97 ng/L, 57.58±2.18 ng/L and 75.60±2.57 ng/L,39 respectively. The MR-Pro-ADM levels before treatment (0 h), during treatment (12th, 24th, 48th, and 72nd hours) and control group was follows; 117.88±7.75 ng/L, 113.63±5.18 ng/L, 109.97±5.25 ng/L, 114.50±5.35 ng/L, 111,84±5.63 ng/L,65.31±2.81 ng/L, respectively. The serum MR-Pro-ADM levels in calves with sepsis were significantly higher than those in the control group before and during treatment (P < 0.05). Also, the serum sTREM-1 level was significantly lower before and after treatment in the sepsis group compared with the control group (P < 0.05). MR-Pro-ADM and sTREM-1 were more important, especially in terms of diagnosis in evaluating calves with neonatal sepsis.
Ruminal Acidosis Part II: Diagnosis, Prevention and Treatment
Authors: Voulgarakis N , Athanasiou LV , Psalla D , Gougoulis D , Papatsiros V , Christodoulopoulos G
Published: January 2024

Ruminal acidosis is presented as the most significant nutritional disorder of ruminants with severe impact on animal health, welfare and considerable economics losses in ovine and bovine herds. The disease is presented in two forms Acute Ruminal Acidosis (ARA) and Sub-Acute Ruminal Acidosis (SARA). This second part of the Ruminal Acidosis review focuses on the diagnosis, prevention, and treatment. The diagnosis of SARA presents several difficulties due to the non- clinically patent symptoms. Prevention and treatment are based on the amelioration of nutrition including the use of dietary supplements, and antimicrobial administration as well as the improvement of management practices.
Effects of different levels of iron, iodine and vitamin B12supplementation on egg quality and antioxidant capacity of eggs at different times of storage in laying hens
Authors: Aghdashi MN , Nobakht A , Mehmannavaz Y
Published: January 2024

The experiment was carried out to evaluate the effects of adding different levels of iron salts, iodine and vitamin B12 on yield, quality traits and antioxidant capacity of eggs in laying hens. A total of 320 laying hens (HyLine Variety White, 28 wk old) in a 2x2x2 factorial experiment were randomly assigned to 8 groups, and each group consisting of 40 hens (5 replicates of 8 hens each) for a period of approximately 13 weeks in a completely randomized design. Hens in the control group received a basal diet with no supplementation whereas hens in treat 2 received basal diet supplemented with 400 mg Fe/kg as FeSO4, treat 3 (basal diet + 450 mg I/kg as KI), treat 4 (basal diet + 0.1 mg B12vit/kg), treat 5 (basal diet + 400 mg Fe/kg as FeSO4 + 450 mg I/kg as KI), treat 6 (basal diet + 400 mg Fe/kg as FeSO4 + 0.1 mg B12Vit/kg), treat 7 (basal diet + 450 mg I/kg as KI + 0.1 mg B12Vit/kg), treat 8 (basal diet + 400 mg Fe/kg as FeSO4 + 450 mg I/kg as KI + 0.1 mg B12Vit/kg), respectively. The results showed that the use of iodine and vitamin B12 increased the shell thickness of eggs (P<0.05). The use of iron, iodine and vitamin B12 supplements increased the antioxidant capacity of eggs compared to the control group (P<0.05). The highest antioxidant capacity of eggs (0.77) was observed when these three supplements were used together in the diet of laying hens. The length of storage had significant effects on the weight of albumin and yolk and antioxidant content of eggs (P<0.05). The highest weight of albumin and antioxidant content was at the beginning of storage, while the highest weight of yolk was obtained in 4 weeks after storage, with increasing of storage time to 8 weeks, all three attributes of albumin weight, yolk weight and antioxidant content of eggs decreased (P<0.05). The related effects of interval of the storage and the experimental supplementation, the use of iron, iodine and vitamin B12 supplements increased the antioxidant capacity of eggs, so that the highest amount of antioxidants in eggs in 8 weeks after storage and by supplementing the diets with all three additives (P<0.05). According to the present experiment, the use of iron, iodine and vitamin B12 additives in the diet of laying hens, improves the performance, the content of iron and iodine elements in eggs and maintains the suitable condition of eggs during storage.
Effects of α-Tocopherol on chilled quality parameters of Tharparkar bull semen extended in Lecithin and Tris based egg yolk extender
Authors: Channo A , Kaka A , Memon AA , Malhi MC , Bakhsh M , Kalwar Q , Kalhoro DH , Sethar A , Jariko RA
Published: January 2024

In this experiment, four healthy Tharparkar Cattle Bulls, 4-5 years aged were used. Total 52 (n=13) ejaculates were collected, and the semen samples having motility, morphology and viability ≥70% were processed and extended into BIOXcell­­­TM and Tris Based Egg Yolk extender supplemented with and without α-tocopherol (Vitamin E) 0.02 Mm/ml. Pre-thawed assessment of motility, morphology, viability and membrane integrity with BIOXcell­­­TM + α-tocopherol (Vitamin E) (79.09±0.87, 86.13±0.79, 82.13±1.20, 81.40±0.77) showed improved quality parameters as compared to Tris+ α-tocopherol (Vitamin E) (74.69±0.94, 82.81±1.00, 77.63±1.26, 77.31±1.01), BIOXcellTM (73.55±1.20, 80.81±0.96, 76.02±1.28, 75.31±1.20) and Tris (71.72±1.28, 78.90±1.01, 74.04±1.31, 73.18±1.29) respectively. In conclusion supplementation of α-tocopherol (Vitamin E) improves the Pre thawed quality parameters i.e. Motility, Morphology, Viability and Membrane Integrity of Tharparkar Bull semen extended in BIOXcell­­­TM and Tris Based Egg Yolk extender.
Some Meat Quality Traits and Fatty Acid Composition of Saanen, Turkish Hair × Saanen (F1 ) and Honamlı × Saanen (F1 ) Crossbreed Kids
Authors: Akbaş AA , Kuleaşan Ş , Üstüner H , Elmaz Ö , Sarı M , Saatcı M
Published: January 2024

The study was aimed to investigate the possibilities of obtaining slaughtered kids using indigenous breeds in Saanen flocks, which does not require breeding. The cross-sectional surface of the Musculus longissimus dorsi (MLD) muscle was used to evaluate the some meat quality parameters. Evaluations were made after slaughtering and at 24th hour and on 7th day after the slaughtering. The average values of pH, pH 24, cooking loss, water holding capacity and shear force values obtained in research groups were 6.46, 5.02, 24.58%, 3.25% and 3.67 kg / cm2 in Honamlı x Saanen; In the same order, 6.46, 5.69, 25.66%, 5.59% and 4.52 kg / cm2 in Saanen and 6.62, 5.27, 22.69%, 2.55% and 4.25 kg / cm2, in the Turkish Hair x Saanen (F1) respectively.  It was found in the study that L0 (brightness), a0 (redness) and b0 (yellowness) values were 47.50, 7.51 and 12.67 for Honamlı x Saanen crossbred kids, respectively. The same values were 48.34, 7.74, and 12.62 for Saanen kids and 47.73, 8.01, and 13.20 for Turkish Hair x Saanen crossbred kids, respectively. In the study, the amount of muscle fat in Turkish Hair x Saanen (F1) crossbred kids was found 2.85%. While there was no difference in oleic acid content among genotypes, the ω-6 fatty acids linoleic and arachidonic were detected in the Saanen kids with a maximum of 10.67% and 4.98%, respectively (P< 0.05). According to findings, It was found that Honamlı x Saanen (F1) cross kids have shown beter performance for many traits than others. Therefore, Saanen farms which has no need young breeding animal can use Honamlı bucks as patternal line for the butchered kid production. This application can be introduced to the sector.
Effects of Somatotropic Axis Gene Polymorphisms on Milk Yields in Simmental Cattle
Authors: Sonmez Z , Kopuzlu S , Özdemir M
Published: January 2024

Due to the increasing world population, scientists aim to obtain high-yield products using new techniques and methods to meet needs in the fields of food, agriculture, and livestock. It is very important to selected the candidate genes and markers correctly, especially in the QTL and MAS techniques in livestock. Somatotropic axis genes affect yield traits, growth, reproduction, and milk production in cattle. In the study, we determined GH/AluI and IGFI/SnaBI gene polymorphisms using the PCR-RFLP technique in DNA samples obtained from 70 Simmental cattle. The allele frequencies of the genes were in the same proportion as 0.62 and 0.38, L and V for the GH gene and T and C for the IGFI gene. There was no significant relationship between the polymorphic genotypes of the genes we examined and lactation milk yields, 305-day milk yields, daily milk yields, and lactation periods of Simmental cattle. The probability of using bGH/AluI and IGFI/SnaBI genetic variations as markers in association studies with milk yield in cattle is extremely low.

Keywords: Axis genes; RFLP; MAS; Simmental; milk yield
The effects of rosemary essential oil supplementation on growth performance, rumen flora and antioxidant blood parameters in growing Merino lambs
Authors: Cetin I , Cetin E , Karakcı D , Ercetin E , Bugdayci Kırmızı O , Yeşilbağ DY
Published: January 2024

Thirty-two male growing Merino lambs (78 ± 5 days of age) were used in a 45-day randomized complete block desing to determine the effects of rosemary essential oil (REO) on the growth performance, rumen fermentation, rumen protozoa population, plasma antioxidant enzyme parameters and fecal microbiology. The control group was fed a diet consisting of concentrate and alfalfa hay. The lambs in control group did not receive REO whereas each lamb in experimental groups supplemented with 250 mg/d (R250), 500 mg/d (R500) and 750 mg/d (R750) REO throughout the study. There weren’t statistically differences (P>0.05) in average initial weight, average final weight, live weight gain, average daily gain, daily feed intake, daily dry matter intake and feed conversion ratio between the control and experimental groups. There were also no differences (P>0.05) in the rumen pH, fecal pH, NH3N and rumen volatile fatty acid (VFA) profile of the control and experimental groups. At the end of the study, although the plasma superoxide dismutase (SOD) value increased significantly (P<0.05) in the experimental groups (R500 and R750), glutathione peroxidase (GPX) and catalase values did not differ between REO groups and control. In addition, the fecal microorganism profile did not differ statistically (P>0.05) between the control and experimental groups. The results of this study show that the addition of REO to Merino lamb rations is more effective on antioxidant parameters than on performance parameters and can be used as a natural antioxidant product
Investigation of Genetic Polymorphisms of CSN1S1 and BLG Genes in Norduz sheep by PCR-RFLP method
Authors: Çak B , Yılmaz O , Demirel AF
Published: January 2024

This study was undertaken to examine genetic polymorphisms of Alpha-S1 casein (CSN1S1) and β-Lactoglobulin (BLG) genes in Norduz sheep by PCR-RFLP method. In the study, 10 ml blood samples were taken from 102 heads of Norduz sheep into tubes with EDTA. DNA isolation from blood samples was done with ready-made commercial kits. The target DNA region of alpha-s1 casein and beta-lactoglobulin genes was amplified by PCR technique. The obtained PCR patterns were digested with MboII and RsaI restriction enzymes to determine the genotypes of Alpha-S1 casein and β-lactoglobulin genes, respectively. The cut fragments were run on 2% agarose gel electrophoresis and genotypes were determined under UV light. Statistical analysis, after calculating allele and genotype frequencies by direct gene counting method, the distribution of observed and expected genotypic frequencies was determined according to the Hardy-Weinberg Equilibrium, and whether it was compatible with the χ2 test. β-Lactoglobulin AA, AB and BB genotype frequencies were found to be 17.6%, 69.6 and 12.7%, respectively. It was determined that the β-Lactoglobulin gene was not in Hardy-Weinberg Equilibrium. AlphaS1-Casein AA, AC and CC genotype frequencies were determined as 0.0, 2.9 and 97.1%, respectively. The Alpha-S1 casein gene was determined to be in Hardy-Weinberg equilibrium. It was determined that Norduz sheep showed polymorphism in terms of Alpha-S1 Casein and β-Lactoglobulin genes. In conclusion, it was determined that the A allele of the β-Lactoglobulin gene and the AB genotype were more common, the C allele and the CC genotype of the Alpha-S1 casein gene were more common, and the AA genotype was absent in Norduz sheep. It was concluded that it would be useful to investigate the economic effects of genetic polymorphisms of Alpha-S1 casein and β-Lactoglobulin genes on various yield traits in larger Norduz sheep populations.
Controlling the photoperiod to raise the melatonin content of sheep milk. Photoperiod control and milk melatonin content
Authors: Keskin M , Gül S , Karaaslan İ , Yakan A
Published: January 2024

The aim of this study was to determine the effect of changing photoperiod time on the melatonin content of sheep milk. The animal material of the study consisted of 40 heads of Awassi sheep that gave birth in May 2021. The sheep were given roughage containing dry matter with 2.5% of their body weight and concentrated feed (2400-2600 kcal ME and 15-16% Crude Protein) as the 40% of their milk yield each day during the lactation period. The experimental ewes were randomly assigned into two groups with 20 animals in each. While the control group sheep were managed with normal day-time length during the lactation, the photoperiod restriction group were kept in the shed with 16 hours of darkness and 8 hours of daylight for 2 months. At the end of the two months, ewes of the both groups were managed in normal daylight until the end of lactation period. During the photoperiod restriction term, milk samples were taken at an interval of 15 days, while the milk composition was determined by a milk analyser and melatonin contents were determined by using LC MS/MS. In addition, lactation milk yield and lactation periods were estimated for all sheep. Statistical evaluation of the obtained data was done by using the SPSS package program. At the end of the study, the application of the extended dark period was found to be affected milk yield (P<0.05) as well as melatonin amount in the milk (P<0.001). Significantly higher melatonin amount was observed in the milk of sheep kept in a long-term dark environment compared to those exposed to normal photoperiod (11.1±7.24 pg/ml vs 6.1±4.55 pg/ml; P<0.001). As a result, it was determined that the prolonged dark period during a day increases the milk melatonin content. It can be also stated that the sheep's milk to be produced with this application could be a product that could take place in the functional food market.
Effect of carob (Ceratonia siliqua) on growth parameters and viability of local Algerian rabbit populations (Oryctolagus cuniculus)
Authors: Meziane R , Boughris F , Boughris M , Boudib FZ , Khenissa R
Published: January 2024

The objective of this study is to evaluate the effect of incorporating different levels of carob on carcass quality and the viability of the local rabbit in eastern Algeria. Carob diets with 3.5 kg/T, 5 kg/T, and 100% carob were distributed to 3 groups of kids from the local population, from weaning at 28 days to slaughter at the age of 110 days. The statistical results show the effect of using carob and also with an incorporation rate of 3.5 kg/T on the live weight of the rabbits and led to a decrease in feed conversion ratio, good feed efficiency, and feeding costs. The highest ADG (28-108 days) and final weight at 108 days are 25.82 g/day, and 1328.37 g respectively. The best performing CI was 3.32, obtained during the growing period for a rabbit weaned at 28 days (Group 1) receiving carob supplementation. As a result, the health risk index, or "HRI," was higher for rabbits in the G1 and G2 whole fattening periods (28-35 and 35-49 days, respectively), and then decreased for the remainder of the period. Mortality and morbidity measurements do not indicate any significant effect of carob use on the health status of rabbits (P < 0.05).The results of this work showed that the supplementation of carob improves the growth performance and dressing yield of local rabbits.
Foundational beliefs in psychotherapy: A response to Alvin Mahrer
Authors: Feltham Colin
Published: January 2024

ABSTRACT IS AVAILABLE IN THE PDF
Αλλαγές στην έννοια του εαυτού των παιδιών κατά τη μετάβασή τους από το νηπιαγωγείο στο δημοτικό σχολείο
Authors: Σωτηρίου Απόστολος , Ζαφειροπούλου Μαρία
Published: January 2024

Η ΠΕΡΙΛΗΨΗ ΒΡΙΣΚΕΤΑΙ ΜΕΣΑ ΣΤΟ ΑΡΧΕΙΟ PDF
Introduction: Shall we or shall we not attempt to uncover our guiding axioms?
Authors: Stalikas Anastassios
Published: January 2024

ABSTRACT IS AVAILABLE IN THE PDF
Η Επίδραση των προσδοκιών επίδοσης στη διαμόρφωση της απόδοσης αιτίων και των συναισθημάτων για ακαδημαϊκή επίδοση σε πραγματικές συνθήκες επίτευξης της τριτοβάθμιας εκπαίδευσης
Authors: Στεφάνου Γεωργία
Published: January 2024

Η ΠΕΡΙΛΗΨΗ ΒΡΙΣΚΕΤΑΙ ΜΕΣΑ ΣΤΟ ΑΡΧΕΙΟ PDF
Twins at puberty:A follow-up study of 32 twin pairs
Authors: Akerman Britta Alin
Published: January 2024

ABSTRACT IS AVAILABLE IN THE PDF