bluuebunny/crossref_metadata_2025 huggingface dataset:
НЕЗГОДА З ВИСНОВКОМ ЕКСПЕРТА ЯК РЕЗУЛЬТАТ ОЦІНКИ ДОКАЗІВ ЗА ВНУТРІШНІМ ПЕРЕКОНАННЯМ
Authors: Циганюк Ю.В. , Шульгін С. О.
Published: December 2023

Анотація. Висвітлено, ґрунтуючись на наукових джерелах і правозастосовній практиці, окремі аспекти незгоди з висновком експерта. Зокрема, заналізовано гарантії, які надаються висновку експерта від зловживань з боку суб’єктів оцінки доказів; допит експерта як один зі способів з’ясування (уточнення, роз’яснення) змісту висновку експерта; призначення додаткової або повторної експертизи для оцінки висновків попередньої судової експертизи; рецензії на висновки судових експертиз у кримінальному провадженні; суб’єкта залучення судового експерта для проведення судової експертизи; перевірку висновку експерта як підґрунтя для формування внутрішнього переконання у вигляді згоди або незгоди з висновком експерта. Методологія. Застосовано загальнонаукові (індукції, синтезу, системний метод), а також спеціальні наукові методи (спеціально-юридичний метод, порівняльно-правовий). Наукова новизна. Розкрито незгоду з висновком експерта як результат оцінки доказів за внутрішнім переконанням, визначено поняття. Виокремлено процесуальні, а також інтелектуальні властивості, які формують таку незгоду з висновком експерта. Здобуті результати. Засвідчено, що незгода з висновком експерта має як процесуальні, так і інтелектуальні властивості. Процесуальні визначені Кримінальним процесуальним кодексом України. Полягають вони в тому, що незгода з висновком експерта становить результат оцінки доказів, які є в ньому як елементу процесу доказування; незгода з висновком експерта має бути мотивована; мотивація має бути складником відповідної постанови, ухвали, вироку; відповідно, суб’єктом такої оцінки є слідчий, дізнавач, прокурор, слідчий суддя, суд (особа або орган, що здійснює провадження). Інтелектуальні властивості незгоди з висновком експерта є результатом мисленнєвої діяльності з узагальнення доказів та їх зіставлення з висновком експерта на основі синтезу та аналізу. Ґрунтуються такі властивості на досвіді особи, яка здійснює оцінку доказів у висновку експерта. Аргументовано, що процесуальні й інтелектуальні властивості збігаються не завжди. Незгода з висновком експерта як результат інтелектуальної діяльності може бути здійснена стороною захисту (а також будь-ким, хто ознайомився з висновком). Процесуальних механізмів для такої незгоди не передбачено чинним законодавством. Проте сторона захисту має право в разі незгоди з висновком експерта заявити клопотання про визнання доказу(ів) недопустимим(и), клопотати про проведення експертизи (повторної, додаткової), самостійно залучити іншого експерта на договірних умовах, клопотати про допит експерта слідчим суддею (на досудовому розслідуванні), судом, висловлювати свою незгоду у промові, репліках.
Management of Critically Ill Patients with Severe Diabetic Ketoacidosis and Acute Renal Failure: A Case Report
Authors: Sucipto Priskila Wulan , I Putu Agus Surya Panji
Published: December 2023

Background: Diabetic ketoacidosis (DKA) is one of the hyperglycemic crises related to diabetes. The main problem in DKA is ketogenesis, a metabolic process that increases the production and decreases the utilization of ketones. DKA is characterized by a biochemical triad such as hyperglycemia, ketonemia, and high anion gap metabolic acidosis. Management of DKA needs to be carried out appropriately and immediately because it may lead to diabetic coma and death.

Case presentation: A 38-year-old woman had decreased consciousness due to metabolic encephalopathy as a complication of severe DKA. The metabolic derangement shows an overlapping high anion gap metabolic acidosis and non-anion gap metabolic acidosis. This case is complicated by acute renal failure. The patient also had been in a hypovolemic state, causing pre-renal acute kidney injury. We treat the patient using a balanced solution to correct hypovolemia. Sonography of the vena cava and blood lactate levels are used to guide fluid resuscitation. We intubate and control the patient's breathing to reduce the metabolic demand. We titrate the insulin infusion until the ketogenesis process is abolished. Antibiotics are given based on sputum culture.

Conclusion: Acute renal failure (ARF) is a rare but potentially fatal complication of diabetic ketoacidosis (DKA). Early recognition and aggressive treatment of ARF during DKA may improve the prognosis of these patients.
Kajian Kesiapan Penerapan Proyek Penguatan Profil Pelajar Pancasila (P5) Dalam Menyongsong Penerapan Kurikulum Merdeka Berdasarkan Persepsi Guru Sebagai Tenaga Pendidik di SMKS Karsa Mulya Palangka Raya
Authors: Sitinjak Tarita Aprilani , Ni Putu Diah Agustin Permanasuri  , Trissan Whendy
Published: December 2023

Tujuan khusus dari penelitian ini adalah untuk mengkaji bagaimana kesiapan SMKS Karsa Mulya  dilihat dari guru sebagai pendidik, dalam pelaksanaan P5 pada kurikulum merdeka. Penelitian ini adalah penelitian dasar, yang berorientasi kepada penjelasan guna mengantisipasi suatu gejala/fenomena yang timbul dengan adanya projek penguatan profil pelajar pancasila (P5) untuk mendukung implementasi kurikulum merdeka. Tema penelitian ini termasuk dalam peningkatan Sumberdaya Manusia (SDM). Waktu pelaksanaan penelitian dilakukan secara keseluruhan selama satu tahun, dimulai dari observasi,pengumpulan data, analisis data dan pelaporan Pengumpulan data skunder dilakukan dengan observasi dan wawancara, sementara untuk data primer dikumpulkan dengan menggunakan kuesioner sebagai instrument penelitian untuk mengetahui pendapat guru sebagai tenaga pendidik tentang kesiapan dan pelaksanaan projek penguatan profil pelajar Pancasila (P5). Hasil penelitian terhadap aspek kesiapan guru dalam mempersiapan instrumen modul ajar dan modul projek dari P5 adalah 3,61. Analisis kesiapan aspek sarana prasarana sekolah dan ekosistem sekolah menurut tenaga pendidik ditunjukan dengan nilai 4,2 yang artinya siap dalam mendukung pelaksanaan P5. Hal ini mengacu dari konversi Pendekatan Acuan Patokan (PAP), nilai X (rata-rata tiap aspek) sebesar 4,2 maka X berada pada skala 4 karena 3,4< X 4,2 .
Controlling the Polarization of Ferroelectrics to Obtain Additional Energy
Authors: Zubtsov V. I.
Published: December 2023

A small-size installation created using ferropiezoelectric ceramics for generating additional electric power is considered. The use of an electrochemical generator in the plant improves the efficiency of power generation by controlling the polarization of ferropiezoelectric ceramics and applying innovation. At consumption of 1 joule of electricity (due to mechanical energy), 2...4 joules of electricity are generated at the output. The technology of energy increase is realized in two stages: at the first stage the degree of polarization of the ferroelectric element is increased, and at the second stage the electric power supplied to the load is increased. The efficiency of the electrical installation is about 55...60% and depends on the modification of ceramics and electrical circuitry.
ESG, Public Pensions, and Compelled Speech
Authors: Kubisch Mark R.
Published: December 2023

Investing based on Environmental, Social, and Governance (“ESG”) principles has dramatically increased in recent years. Many institutional investors— including public pension funds funded by mandatory contributions from government employees—now incorporate ESG principles into their investment and engagement strategies even though certain aspects of ESG, such as investing to reduce carbon emissions, are politically controversial. Over this same period, courts have reaffirmed that the First Amendment protects individuals from being compelled to associate with or to subsidize the speech of third parties. Indeed, applying this compelled speech doctrine, the Supreme Court recently overruled a forty-year-old precedent that allowed states to force nonunion members to contribute to public unions engaged in collective bargaining on their behalf.

This Article provides the first in-depth discussion of how the Court’s compelled speech doctrine might apply both in the wake of the Supreme Court’s landmark decision in Janus v. AFSCME and in light of the dramatic rise of ESG investing. In doing so, it explains how the Supreme Court’s post-Janus compelled speech doctrine will likely render state mandates requiring employees to contribute to public pension funds that invest according to ESG principles unconstitutional. And this Article also identifies two potentially serious consequences of the unconstitutionality of such mandates that current scholarship does not address. First, application of the compelled speech doctrine to public pensions may cause state and local governments significant financial distress, given that state employees might be able to withdraw all contributions (not just future contributions) to the public pension funds even as many of those funds are substantially underfunded. Second, extending the compelled speech doctrine to ESG investing might further hamper efforts to increase retirement savings among those least likely to save for retirement by precluding auto-enrollment of employees in retirement programs that invest according to ESG principles. Finally, this Article sketches some possible approaches to addressing these issues before concluding.
Redefining "Beneficial Use" to Combat Water Scarcity
Authors: Adams Genene
Published: December 2023

Many western states in the U.S. are experiencing severe or exceptional drought, where water shortages are common, widespread, and have created troubling emergency conditions. How long these droughts plaguing the West will last is unknown. What is evident, however, is water use under a wellestablished doctrine must change in order to ensure communities do not run out of water. As a decades-long drought persists, frequent higher-than-average temperatures linger due to climate change, and population growth skyrockets, the need to implement a narrower standard for water use in the West is critical.

The purpose of this Comment is to propose an amendment to the prior appropriation doctrine such that the doctrine promotes sustainable water use, ultimately acting as a hedge against current and future water scarcity crises. This Comment begins with an overview of the current water scarcity crisis, including drought conditions throughout western parts of the United States. Part III then provides a summary of the prior appropriation doctrine, paying special attention to the doctrine’s most important element—beneficial use— before moving into a brief discussion of the main benefits and drawbacks of the current definition of beneficial use. This Comment will end by presenting a modified definition of beneficial use to better equip prior appropriation states with managing water use in areas prone to drought, followed by discussion of likely criticisms of such a redefinition.
З ДОСВІДУ МЕРЕЖЕВОЇ ВЗАЄМОДІЇ ІНСТИТУТУ ПЕДАГОГІЧНОЇ ОСВІТИ І ОСВІТИ ДОРОСЛИХ ІМЕНІ ІВАНА ЗЯЗЮНА НАПН УКРАЇНИ ТА ЗАКЛАДІВ ВИЩОЇ ПЕДАГОГІЧНОЇ ОСВІТИ УКРАЇНИ
Authors: Lukianova Larysa
Published: December 2023

Висвітлено результати мережевої взаємодії Інституту педагогічної освіти і освіти дорослих імені Івана Зязюна НАПН України із закладами вищої педагогічної освіти. Обґрунтовано методологію партнерської взаємодії, яка ґрунтується на системному і діяльнісному підходах, що забезпечують спільну діяльність інституцій-партнерів з метою досягнення синергетичного ефекту педагогічного партнерства. Зазначено, що Інститут здійснює консультативну, методичну, психологічну підтримку суб’єктів взаємодії, а також підвищення кваліфікації науково-педагогічних працівників, проводить експертну оцінку програм розвитку працівників закладів вищої освіти. Інституції-партнери беруть участь у спільній експериментальній і проєктній діяльності, сприяють проведенню апробації і впровадженню результатів дослід-жень, підтримують технологічний трансфер. Представлено результати мережевої взаємодії, які репрезентовано у п’яти контекстах: науково-методичному, експериментальному, науково-організаційному, просвітницькому, інформаційно-ресурсному, реалізація яких відбувається на трьох рівнях (інституційному, міжгалузевому, міжнародному). Визначено перспективи поглиблення мережевої взаємодії.
PREVENTION OF EMBEZZLEMENT OF BUDGET FUNDS ALLOCATED IN THE FORM OF GRANTS AND SUBSIDIES: IMPLEMENTATION OF ESCROW ACCOUNTS
Authors: Мангасаров Р.А.
Published: December 2023

На протяжении последних лет в России сохраняется стабильно высокий уровень хищений бюджетных средств. Это условие выступает причиной поиска механизмов противодействия указанным видам преступлений. В статье рассмотрены вопросы применения цифровых технологий, направленных на защиту бюджетных средств от хищений. Отмечены некоторые проблемы предупреждения указанных преступлений, а также предложены механизмы, повышающие эффективность деятельности правоохранительных органов в борьбе с данными противоправными деяниями посредством использования цифровых технологий и счетов эскроу. По мнению автора, нормативно-правовое закрепление счетов эскроу и их внедрение в сфере государственной поддержки (в рамках бюджетных грантов и субсидий) и в других областях, связанных с куплей-продажей объектов недвижимости и земельных участков; приобретением и продажей товаров, прав на результаты интеллектуальной деятельности; оказанием услуг и проведением работ и т. д., будет способствовать усилению контроля за бюджетными средствами, в том числе выделенными в виде грантов и субсидий, а также сократит количество совершаемых хищений.

In recent years, Russia has maintained a consistently high level of embezzlement of budget funds. This condition is the reason for the search for mechanisms to counter these types of crimes. The article deals with certain issues of the use of information and communication and digital technologies in order to prevent misuse and embezzlement of budget funds, some existing problems of countering these crimes are noted and measures are proposed to improve the effectiveness of the activities of internal affairs bodies to counteract these illegal acts through the use of information resources, digital technologies and escrow accounts. According to the author, the regulatory and legal consolidation of escrow accounts and their implementation in the field of state support (within the framework of budget grants and subsidies) and in other areas related to the purchase and sale of real estate and land plots; the acquisition and sale of goods, intellectual property rights; the provision of services and work, etc. it will contribute to strengthening control over budget funds, including those allocated in the form of grants and subsidies, and will also reduce the number of embezzlements committed.
PERSONNEL POLICY OF THE PENAL SYSTEM AS A BASIS FOR THE FORMATION OF PROFESSIONAL STAFF POTENTIAL
Authors: Панарин Д.А. , Брыков Д.А.
Published: December 2023

Одной из основных целей Концепции развития уголовно-исполнительной системы Российской Федерации на период до 2030 года является повышение эффективности уголовно-исполнительной системы путем совершенствования организации ее деятельности и формирования высокомотивированных и профессиональных кадров. В статье рассматриваются отдельные элементы кадровой политики УИС, их характеристики, а также вопросы планирования и правового регулирования деятельности кадровых служб территориальных органов ФСИН России. На основе комплексного подхода и анализа эмпирического материала установлено, что деятельность кадровых подразделений осуществляется с учетом конкретной управленческой ситуации. Анализируя положения о кадровых аппаратах территориальных органов ФСИН России, авторы отмечают отсутствие принципиальных отличий как в их структуре, так и в содержательной части. Обозначена незначительная разница в распределении функций и задач между структурными подразделениями кадрового аппарата территориального органа ФСИН России. На основе проведенных исследований авторами предлагается перечень вопросов, которые следует отразить в положениях о структурных кадровых подразделениях, что в свою очередь будет способствовать оптимизации организационно-штатной структуры учреждений и органов УИС.

One of the main goals of the Concept of Development of the Penal System of the Russian Federation for the period up to 2030 is to increase the efficiency of the Penal System by improving the organization of its activities and the formation of highly motivated and professional personnel. The article deals with individual elements of the personnel policy of the Penal System, their characteristics, as well as issues of planning and legal regulation of the activities of personnel services of the territorial bodies of the Federal Penitentiary Service of Russia. Based on an integrated approach and analysis of empirical material, it is established that the activities of personnel departments are carried out taking into account a specific management situation. Analyzing the provisions on the personnel apparatus of the territorial bodies of the Federal Penitentiary Service of Russia, the authors note the absence of fundamental differences both in their structure and in the content part. There is a slight difference in the distribution of functions and tasks between the structural divisions of the personnel apparatus of the territorial body of the Federal Penitentiary Service of Russia. Based on the conducted research, the authors propose a list of issues that should be reflected in the regulations on structural personnel units, which in turn will contribute to the optimization of the organizational and staff structure of institutions and bodies of the UIS.
Open-DPSM: An open-source toolkit for modeling pupil size changes to dynamic visual inputs
Authors: Cai Yuqing , Strauch Christoph , Van der Stigchel Stefan , Naber Marnix
Published: December 2023

Pupil size change is a widely adopted, sensitive indicator for sensory and cognitive processes. However, the interpretation of these changes is complicated by the influence of multiple low-level effects, such as brightness or contrast changes, posing challenges to applying pupillometry outside of extremely controlled settings. Building on and extending previous models, we here introduce Open Dynamic Pupil Size Modeling (Open-DPSM), an open-source toolkit to model pupil size changes to dynamically changing visual inputs using a convolution approach. Open-DPSM incorporates three key steps: (1) Modeling pupillary responses to both luminance and contrast changes; (2) Weighing of the distinct contributions of visual events across the visual field on pupil size change; and (3) Incorporating gaze-contingent visual event extraction and modeling. These steps improve the prediction of pupil size changes beyond the here-evaluated benchmarks. Open-DPSM provides Python functions, as well as a graphical user interface (GUI), enabling the extension of its applications to versatile scenarios and adaptations to individualized needs. By obtaining a predicted pupil trace using video and eye-tracking data, users can mitigate the effects of low-level features by subtracting the predicted trace or assess the efficacy of the low-level feature manipulations a priori by comparing estimated traces across conditions.
Metaanálisis de la Inspección Visual con Ácido Acético IVAA y su Utilidad como Predictor de Lesiones del Cuello Uterino
Authors: Zerna Bravo Cruz Marisol , Torres Romero Gloria del Carmen , Viteri Rojas Ana María , Palacios Tavara María del Socorro , Echeverria Pazmiño Matilde Emperatriz
Published: December 2023

Las lesiones de cuello uterino representan uno de los problemas más severos para el sistema de salud nacional. Por ello se planteó como objetivo general, realizar un metaanálisis de la inspección visual con ácido acético (IVAA) y su utilidad como predictor de lesiones del cuello uterino, como un aporte al desarrollo de estudios científicos que contribuyan a la reducción de la tasa de defunciones por cáncer cervicouterino. Se aplicó como metodología, un meta-análisis derivado de la revisión bibliográfica de 6 investigaciones asociadas al tema en estudio que, reposan en bases de datos científicas como Scielo, Dialnet, entre otras, en las cuales se encontraron como resultados principales, un promedio de edad de 39,16 años, con edad máxima de 45,37 y mínima de 32,17 años; sensibilidad y especificidad promedio de la prueba IVAA de 89% y 84% respectivamente, con valores mínimos y máximos que se situaron entre 70% al 100%; mientras que, el valor predictivo positivo obtuvo una media de 66% y el valor predictivo negativo tuvo un promedio de 82%, destacándose que en todos los casos, la desviación estándar y las varianzas fueron bajas. En conclusión, los indicadores obtenidos en este estudio pusieron de manifiesto que, la prueba IVAA es un importante predictor de daños cervicouterinos en las mujeres, especialmente de quienes alcanzan los 40 años, la cual puede ser utilizada para la prevención de complicaciones que puede generar este tipo de carcinoma y minimizar la tasa de morbi-mortalidad por cáncer del cuello uterino, teniendo muy bajo costo.
Aplikasi E-Commerce Berbasis Android Pada Toko Jersey RH
Authors: Sofia Detin , Royadi Refi Nabillah , Septiawan Ricki
Published: December 2023

Toko Jersey RH merupakan toko yang bergerak dalam bidang fashion, khusus nya fashion baju bola jersey, masalah yang dialami Toko Jersey RH yaitu sulit dalam memasarkan produk, sulit dalam melakukan transaksi, sulit dalam manajemen data penjualan karena masih mendata secara manual dengan buku tulis, masalah tersebutlah yang menjadi latar belakang penulisan jurnal aplikasi e-commerce di Toko Jersey RH, karena dengan adanya aplikasi e-commerce di Toko Jersey RH maka akan memudahkan sang penjual dan sang pembeli karena semua nya sudah diatur secara otomatis oleh aplikasi e-commerce itu sendiri. Aplikasi e-commerce Toko Jersey RH merupakan aplikasi e-commerce berbasis android, aplikasi ini dikembangkan menggunakan metode waterfall yang memiliki beberapa tahapan yang berurutan yaitu, Analisa Kebutuhan, Desain Sistem, Penulisan Kode Program, Pengujian Program, dan Penerapan Program, Kesimpulan dari penulisan jurnal aplikasi e-commerce pada Toko Jersey RH adalah mempermudah pembeli dalam membeli suatu produk tanpa harus datang ke toko, karena dengan adanya aplikasi e-commerce pada Toko Jersey RH akan mempermudah dalam transaksi, mempermudah dalam memasarkan produk, dan mempermudah dalam mendata penjualan, mulai dari mendata produk, mendata transaksi, dan mendata keuangan.
A review of the subgenus Loxocera Meigen, 1803 (Diptera, Brachycera, Psilidae) in China
Authors: Zhou Jiale , Yang Ding
Published: December 2023

The subgenus Loxocera (Loxocera Meigen, 1803) (Diptera, Brachycera, Psilidae) in China is reviewed. Six species are recognized, including four new species: L. (L.) chikunisp. nov., L. (L.) lonsdaleisp. nov., L. (L.) maculithoraxsp. nov., and L. (L.) obscurasp. nov. Two species originally placed in the subgenus Loxocera, L. anulata Wang & Yang, 1998 and L. tianmuensis Wang & Yang, 1998, are transferred to the subgenus Loxocera (Imantimyia Frey, 1925). A key to the species of the subgenus Loxocera occurring in China is provided.
L'appel au soin et à la solidarité dans notre société
Authors: Brugère Fabienne , Ricot Jacques , Salvan Chloé , Sarthou-Lajus Nathalie
Published: December 2023

De la petite enfance à la fin de vie, en passant par toutes les situations où nous sommes exposés à la dépendance, la question du soin prend une importance grandissante dans notre société. À travers l’insistance sur des sujets comme la sollicitude, la vulnérabilité et même l’invisibilité sociale, la pensée contemporaine n’est-elle pas devenue, comme l’Église que le pape appelle de ses vœux, un hôpital de campagne après la bataille néolibérale ? Qu’est-ce que le courant du care et comment rencontre-t-il les théories du genre ? Comment faire pour que le soin ne soit pas exclusivement l’affaire des femmes ?
La place de la religion dans la vie politique
Authors: Ferry Jean-Marc , Valadier Paul , Sarthou-Lajus Nathalie , Schlegel Jean-Louis
Published: December 2023

Chacun s’accorde à reconnaître une insuffisance, voire « une détresse du politique » face aux transformations et aux interrogations qui taraudent les sociétés libérales. Qu’est-ce qui caractérise cette fragilité du politique ? Est-ce qu’un nouvel élan peut être apporté par le christianisme ? Concrètement, sur quels terrains ? Comment la présence de l’islam a-t-elle transformé les rapports entre démocraties européennes et religions ?
L'innovation par le verbe et l'image
Authors: Boyer Frédéric , Novarina Valère , Sarthou-Lajus Nathalie , Euvé François
Published: December 2023

Il existe un lien privilégié entre Les Écritures et l’écriture, entre le christianisme, la littérature et la poésie. En régime chrétien, La Nouvelle traduction de la Bible (Bayard 2001) est le dernier chantier d’envergure innovateur d’un point de vue biblique et littéraire. Comment ce travail a-t-il contribué à féconder les œuvres d’une génération d’écrivains comme Valère Novarina et Frédéric Boyer ? Une nouvelle vitalité du christianisme peut-elle advenir du côté de la littérature contemporaine ?
Le Royaume de Carrère, les raisons d'un succès
Authors: Darrigrand Mariette
Published: December 2023

Le Royaume d’Emmanuel Carrère est certes un roman critiquable d’un point de vue littéraire et même exégétique – ce travail critique n’a d’ailleurs presque pas été fait. Mais sur un plan psychosociologique, il constitue un objet contemporain riche d’indications sur le rapport qu’entretient aujourd’hui la société ou, plus précisément, la presse française avec la religion catholique.
Vers une Église « liquide »
Authors: Join-Lambert Arnaud
Published: December 2023

Les mutations du rapport entre l’Église et la société mettent en question le modèle traditionnel de la paroisse. Des essais de nouvelles paroisses sont tentés. L’hypothèse est d’appliquer aux communautés chrétiennes le qualificatif de « liquide » emprunté au sociologue Zygmunt Bauman. Cela permettrait de retisser les liens entre les communautés chrétiennes et l’ensemble de la société.
Les Ukrainiens au tournant de l'histoire européenne
Authors: Lebedev Anna
Published: December 2023

Les événements dramatiques de l’an dernier ont contribué à faire connaître l’Ukraine en Occident. L’analyse du phénomène « Maïdan » révèle les divisions du pays mais aussi un sentiment patriotique partagé.
Surmonter le chômage de longue durée
Authors: Soulage François
Published: December 2023

Dans une France qui compte actuellement 3 500 000 chômeurs de catégorie A, c’est-à-dire n’ayant pas occupé un emploi au cours du mois précédent, et 5 400 000 personnes qui n’ont pas travaillé ou ont travaillé moins de 75 heures dans le mois précédent, le chômage de longue durée est un véritable fléau. C’est pourquoi on pouvait penser que le gouvernement en ferait un enjeu prioritaire.
Le coaching, un symptôme de fragilité du lien social
Authors: Le Coz Pierre
Published: December 2023

On a longtemps voulu y voir un simple phénomène de mode. Mais, aujourd’hui, il faut se rendre à l’évidence : le coaching a pris racine dans notre culture. En l’espace de trois décennies, il s’est émancipé de son contexte sportif d’origine pour s’étendre à l’ensemble du monde professionnel.
Le hizmet de Fethullah Gülen
Authors: Balci Bayram
Published: December 2023

Bien connu des analystes et des chercheurs sur la Turquie, le mouvement socio-religieux turc de Fethullah Gülen, jusqu’ici très discret, est apparu au grand jour récemment. En effet, depuis décembre 2013, les médias se font l’écho de la guerre fratricide qui l’oppose à son allié d’hier, le gouvernement néo-conservateur de Recep Tayyip Erdoğan.
Les rituels de vote en France et au Royaume-Uni
Authors: Faucher Florence , Hay Colin
Published: December 2023

Le vote est une pratique symbolique. Pourtant, les politistes tendent à se focaliser sur les résultats des élections ou sur les motivations du vote, en oubliant la signification symbolique de la pratique elle-même et celle qu’elle a pour les participants. Dans cet article, nous attirons l’attention sur cette dimension à travers une analyse des rituels de vote et France et au Royaume-Uni. Nous considérons ce que les électeurs font lorsqu’ils votent. En particulier, nous nous interrogeons sur la manière dont le choix de l’électeur est conçu comme une performance publique ou comme un acte accompli en privé et en secret. Nous considérons comment des pratiques, typiquement tenues pour évidentes et pourtant distinctes, nous aident à mieux comprendre dans quelle mesure ces actes reflètent des frontières différentes du public et du privé dans les deux pays, et contribuent à construire des conceptions singulières nationales du système politique et du citoyen dans le processus démocratique.
A New Fuzzy Joint Choquet Integral Method Under Interval-Valued Function
Authors: Liu Kaisheng
Published: December 2023

A new fuzzy group decision-making method considering multi-attributes correlation under interval-valued function is presented, which mainly includes (1) acquiring the group fuzzy preference matrix and (2) handling the interactions between multiple evaluation attributes. To do that, firstly, the fuzzy joint Choquet integral based on an interval-valued function is proposed, which not only reflects the interaction between multiple attributes in a complex and uncertain environment, but also retains the initial preference of the decision maker. Secondly, a Shapley value with fuzzy measure is applied to assign each decision maker's weight, and the fuzzy group preference matrix is acquired by fusing the fuzzy preference matrices of all decision makers. Finally, a nursing home selection case is depicted to explain the effectiveness of the proposed technique. The corresponding sensitivity analysis is operated, which clarifies the reliability and flexibility of the proposed technique.
NADPH Oxidase 2–Derived Reactive Oxygen Species Promote CD8+ T Cell Effector Function
Authors: Chen Jing , Liu Chao , Chernatynskaya Anna V , Newby Brittney , Brusko Todd M , Xu Yuan , Barra Jessie M , Morgan Nadine , Santarlas Christopher , Reeves Westley H , Tse Hubert M , Leiding Jennifer W , Mathews Clayton E
Published: December 2023

Oxidants participate in lymphocyte activation and function. We previously demonstrated that eliminating the activity of NADPH oxidase 2 (NOX2) significantly impaired the effectiveness of autoreactive CD8+ CTLs. However, the molecular mechanisms impacting CD8+ T cell function remain unknown. In the present study, we examined the role of NOX2 in both NOD mouse and human CD8+ T cell function. Genetic ablation or chemical inhibition of NOX2 in CD8+ T cells significantly suppressed activation-induced expression of the transcription factor T-bet, the master transcription factor of the Tc1 cell lineage, and T-bet target effector genes such as IFN-γ and granzyme B. Inhibition of NOX2 in both human and mouse CD8+ T cells prevented target cell lysis. We identified that superoxide generated by NOX2 must be converted into hydrogen peroxide to transduce the redox signal in CD8+ T cells. Furthermore, we show that NOX2-generated oxidants deactivate the tumor suppressor complex leading to activation of RheB and subsequently mTOR complex 1. These results indicate that NOX2 plays a nonredundant role in TCR-mediated CD8+ T cell effector function.
Emergency Skills in Athletic Training: Perceived Knowledge and Continuing Education
Authors: Gerlach Brian , Jochum Jessica , Salamh Paul , Moore Elizabeth S.
Published: December 2023

Context

Continuing education (CE) in health care, particularly in athletic training, often fails to meet the needs of its participants. Rapid increases in available information make it necessary for CE to be delivered as efficiently as possible.

Objective

To explore whether an interactive teaching strategy and various characteristics of athletic trainers affected the perceived knowledge of emergency skills among certified athletic trainers.

Design

Quasiexperimental study with a single-group pretest-posttest design.

Patients or Other Participants

Certified athletic trainers (N = 81) at the Great Lakes Athletic Trainers' Association Annual Meeting and Symposium.

Intervention(s)

Emergency skills practice session for anaphylaxis, opioid overdose, diabetes, and asthma.

Main Outcome Measure(s)

Participants completed a preintervention perceived knowledge questionnaire (PKQ) that included background information questions and completed a postintervention PKQ.

Results

A statistically significant difference (P < .001) in PKQ scores from pretest to posttest was found with pretest scores being lower than posttest scores (89.59 and 103.02, respectively). Age and years of experience had a weak correlation with PKQ pretest scores (rs = .32 and rs = .33, respectively). Participant characteristics including additional certification (P = .012), anaphylaxis experience (P = .036), opioid overdose experience (P < .001), diabetes experience (P = .025), and combined emergency experience (P = .029) had significantly different pretest PKQ scores.

Conclusions

The use of an interactive teaching strategy in CE and certain athletic trainer characteristics significantly affected athletic trainers' perceived knowledge of emergency skills.
Baclofen Toxicity in a Patient with End-stage Renal Disease on Maintenance Dialysis
Authors: Ahmed Samar , Kharrat Mahmoud , Salah Hesham , Shearyia Fouad , Alrimawi Reem , Makhsoom Azizah , Al sharif Sahal , Alyami Rozana , Shaheen Faissal
Published: December 2023

Baclofen is a β-(p-chlorophenyl) derivative of the neurotransmitter y-aminobutyrio acid (GABA). This centrally-acting GABA agonist is prescribed as therapy for spasticity in the spinal cord region. The drug is predominantly excreted by the kidney, thus making patients with kidney disease susceptible to side effects. We report on a patient with end-stage renal disease who developed baclofen toxicity, which was successfully treated with intense hemodialysis.
Predictors of hemorrhagic manifestations in dengue: A prospective observational study from the Hadoti region of Rajasthan
Authors: Jelia Shiv Charan , Ajmera Devendra , Airan Divya , Bairwa Ranjeet , Meena Yogesh
Published: December 2023

Objective:

To study the laboratory and clinical predictors of hemorrhagic manifestations in dengue virus-infected patients.

Methods:

This was a single-center hospital-based prospective observational study. 200 Dengue seropositive patients were included in the study. A detailed clinical examination was done and comprehensive laboratory investigations were done. These parameters were compared between patients with and without hemorrhagic manifestations.

Results:

Out of the 200 patients, 47 (23.5%) had bleeding. 64.5% Patients were males and 76.0% were under the age of 40 years. The most common presenting symptoms were fever (100.0%) followed by myalgia (77.0%), nausea and vomiting (56.0%). Leukocytosis, neutrophilia, thrombocytopenia, hyperbilirubinemia, transaminitis, decreased serum albumins, and raised D-dimer can serve as hematological, biochemical, and coagulation predictors of hemorrhagic manifestations for dengue.

Conclusions:

Dengue is a tropical infection with various complications. Bleeding complications are one of them. Laboratory parameters like white blood cells, platelets, bilirubin level, liver enzymes, and D-dimer can help to identify patients at risk for bleeding. Early identification and appropriate management can save a lot of resources and lives.
Clinical profile of medication-related emergencies among patients presenting to the emergency department: An observational study
Authors: Yagadi Srilatha , Guguloth Ramesh Babu , Jacob Mathews
Published: December 2023

Objective:

To determine the clinical profile of patients presenting with medication-related emergencies to the Emergency Department of our institute.

Methods:

This was an observational study conducted between November 2018 and September 2020 at Bangalore Baptist Hospital, Karnataka. A total of 138 subjects who satisfied the inclusion criteria were included in the study. The severity of adverse drug reactions (ADR) is assessed based on the Hurwitz severity assessment scale of ADR. Glasgow coma scale at the time of presentation and source of medication were noted. The type of drug overdose, requirement of advanced airway and vasopressors, and the outcome were also assessed.

Results:

Among medication-related emergencies (n=138) in our study, ADR contributed to 70.3% (n=97) of the study population, and drug overdose accounted for 29.7% (n=41). One-third of the ADR occurred in patients aged above 60 years. Most patients were hemodynamically stable and did not require vasopressors, or advanced airway in both groups. Most patients had Glasgow coma scale ranging from 13-15 in both groups. Nonsteroidal anti-inflammatory drugs were the most used medicine (17/41, 41.5%) and most medications were over the counter drugs (25/41, 61.0%) in the drug overdose group; meanwhile in the ADR group, anti-diabetic medication was the most used medicine (34/97, 35.1%) and most medications were prescribed in the ADR group (93/97, 95.9%).

Conclusions:

Our study shows that ADR is the most common type of medication-related emergency.
Epidemiological characteristics and trends of animal bites in Neyshabur, Iran: A cross-sectional study
Authors: Shariat Mansoore Sarcheshme , Esmaeilzadeh Nayereh , Zerangian Nasibeh , Peyman Nooshin
Published: December 2023

Objective:

To investigate the trend of animal bites between 2015-2021 in Neyshabur, Iran.

Methods:

In this cross-sectional descriptive study, data were retrieved from the vice-chancellery of the Neyshabur University of Medical Sciences. The data included person variables, place and time variables, and animal variables.

Results:

There were 13190 cases of animal bites and the trend was increasing during 2015-2020. Most injuries were caused by dogs (86%), most animal bites (76.6%) occurred in males, and 28.1% of all cases were farmers. The most common bitten parts were the lower limbs (64.8%), often reported as a scratch (83.4%). Most of the biting animals (67.9%) were not strays, and 83.3% of them had bitten their owners. No rabies death was reported during the study period.

Conclusions:

The incidence of animal bites increases and is higher than the national statistics in Neyshabur, Iran. Serious attention and intervention should be given to control and prevent this health threat.
Cryopreserved ovine spermatogonial stem cells maintain stemness and colony forming ability in vitro
Authors: Pramod R. Kumar , Varughese Deepthi , Jameel A. Javed , Panda Bhisma Narayan , Goswami Soma , Mitra Abhijit
Published: December 2023

Objective:

To assess the effect of cryopreservation on stemness and proliferation potential of sheep spermatogonial stem cells (SSCs) in vitro.

Methods:

Sheep testicular cells were isolated and putative SSCs were enriched by the laminin-based differential plating method. Putative SSCs were co-cultured with the Sertoli cell feeder prepared by the Datura Stramonium Agglutinin (DSA-lectin)-based method. The cultured putative SSCs were cryopreserved in Dulbecco's Modified Eagle Medium-10% fetal bovine serum mixture (DMEM-10% FBS) media containing 10% dimethyl sulfoxide (DMSO) alone or 10% DMSO plus 200 mM trehalose. Cryopreserved putative SSCs were evaluated for their proliferation potential using in vitro culture and stemness by immunocytochemistry. Finally, the transfection ability of cryopreserved putative SSCs was analyzed.

Results:

We isolated 91% viable testicular cells from sheep testes. The majority of the laminin enriched cells expressed the SSC related marker, ITGA6. Co-culture of sheep putative SSCs with Sertoli cell feeder resulted in the generation of stable colonies, and the expression of SSC marker was maintained after several passages. A significantly higher number of viable putative SSCs was recovered from SSCs cryopreserved in media containing 10% DMSO and 200 mM trehalose compared to 10% DMSO alone (P<0.01). Cryopreserved putative SSCs formed colonies and showed SSC marker expression similar to the non-cryopreserved putative SSCs. The appearance of green fluorescent colonies over the Sertoli cell feeder indicated that cryopreserved sheep SSCs were successfully transfected.

Conclusions:

Cryopreserved putative SSCs can retain their stemness, colony forming ability, and transfection efficiency in vitro. Our research may help in the effective preservation of germplasm and the generation of transgenic ovine species.
Seasonal stress on semen quality profiles, seminal biochemical and oxidative stress attributes in endangered Teressa goat of Andaman and Nicobar Islands
Authors: Perumal P. , Sunder Jai , De A. K. , Bhattacharya D. , Nahak A. K. , Vikram R. , Chakurkar E. B.
Published: December 2023

Objective:

To measure seasonal effects on semen quality profiles, seminal biochemical and oxidative stress attributes in fresh and liquid stored semen in monsoon and dry seasons.

Methods:

A total of 10 Teressa bucks (3-4 years) were selected from breeding farm, ICAR-Central Island Agricultural Research Institute, Port Blair, Andaman and Nicobar Islands, India. Semen samples (n=25 per season) were collected through artificial vagina method and preserved at refrigerated temperature (5°C) for 48 h using Tris citrate glucose based extender. We detected semen quality parameters [volume, mass activity, pH, sperm concentration, total motility, viability, total sperm abnormality, and plasma membrane, acrosomal and nuclear integrities], biochemical profiles [aspartate amino transferase (AST), alanine amino transferase (ALT) and total cholesterol], and oxidative stress markers [total antioxidant capacity (TAC) and malondialdehyde (MDA)] during monsoon and dry seasons.

Results:

Semen quality parameters significantly differed between seasons (P<0.05) and among storage periods (P<0.05). Volume, pH, mass activity, motility, viability, acrosomal, plasma membrane and nuclear integrities, and TAC were significantly higher (P<0.05). Sperm concentration, sperm abnormalities, MDA, AST, ALT and total cholesterol were significantly lower in fresh semen of monsoon than dry season (P<0.05). Motility, viability, acrosomal, plasma membrane and nuclear integrities, and TAC were significantly decreased (P<0.05) while sperm abnormality, AST, ALT, total cholesterol and MDA were significantly increased as liquid semen storage period advanced (P<0.05).

Conclusions:

Monsoon season has higher beneficial effects on semen quality profiles and liquid stored semen remained usable for upto 48 h. Good quality ejaculates with higher TAC and lower MDA can be cryopreserved and will be used for artificial insemination.
Impact of Anterior Commissure Involvement and Frozen Guided Resections on Oncological Outcomes after Laser Cordectomy in Early Glottic Cancers – A 10-year Retrospective Analysis from a Tertiary Care Cancer Center in India
Authors: Iype Elizabeth Mathew , Vishwani Ankit , Varghese Bipin T , Thomas Shaji , Lal Sahya S
Published: December 2023

Background:

Early glottic cancers can be treated using different options such as transoral laser microsurgery (TLM), open partial laryngectomy (OPL), and radiation therapy (RT). TLM provides similar oncological benefits to OPL in a few subsets of patients, and the quality of voice is comparable to RT, while hospitalization time is reduced. Resection by laser microsurgery of early glottic cancer with anterior commissure involvement (ACI) is more challenging mainly due to difficulty in adequate exposure. The frozen section is reliable in TLM for determining the extent of resection and the real depth which may be masked on videoscopy.

Materials and Methods:

This study is a retrospective analysis of patients with early glottic cancer (Tis, T1) who underwent TLM in a tertiary cancer center in South India from January 1, 2012, to December 31, 2019. All patients were identified from the hospital registry.

Results:

The study included 89 patients, and the median follow-up was 54 months. Out of 89 patients, 14 patients had local recurrence which was managed with salvage TLM/salvage RT/salvage laryngectomy. There were three patients with nondisease-specific deaths. Among the study population, the laryngeal preservation rate was 96.6%, the cause-specific survival rate was 100%, and the overall survival rate was 97.7%. The 3-year disease-free survival rate was 84.4%. ACI and frozen margin positivity were statistically significant poor prognostic factors.

Conclusion:

TLM is a safe and effective treatment of early glottic carcinoma. Apart from tumor (T) staging, ACI and frozen positivity were negative predictive factors. The results suggest the need to consider ACI in the T staging of glottic tumors. Frozen positivity helps us in re-excision but signifies that the disease is deeply infiltrative or aggressive and a vigilant follow-up is required for these patients.
Hyalinizing Clear Cell Carcinoma of the Mandible – A Rare Case Report
Authors: Hussain Mohsina , Shaikh Arif , Dhongde Rajendra , Gandhe Sucheta , Pawar Yogesh , Roy Sirshendu , Nagarkar Raj
Published: December 2023

Hyalinizing clear cell carcinoma (HCCC), also known as clear cell carcinoma is a rare tumor constituting ≤1% of minor salivary gland tumors. We present here the case of a 48-year-old woman with complaints of pain in the left lower jaw with a surgical history of post-marginal mandibulectomy (lesion being benign). However, the postoperative histopathological reports confirmed clear cell carcinoma of the mandible. Due to delay in presenting, a whole-body positron emission tomography scan was performed and reports have shown no evidence of disease elsewhere in the body. Immunohistochemistry was performed and reports suggested HCCC of salivary gland origin. The patient underwent segmental resection of the mandible along with bilateral modified radical neck dissection and reconstruction of the defect with a free fibula flap. The postoperative period was uneventful. The clinical characteristics, differential diagnosis, surgery, histological, immunohistochemical, and treatment for HCCC were reviewed and discussed.
Tooth Movement in Immune System
Authors: Ramadayanti Sonya L. , Caesar Aya D. O. , Amalia Reniyanti , Warizgo Diyan R. , Ardani I Gusti Aju Wahju
Published: December 2023

Aim:

Applying forces to teeth causes orthodontic tooth movement. Orthodontic tooth movement necessitates bone remodeling, brought on by intricate aseptic inflammatory cellular and molecular processes. According to the “pressure-tension” theory, applying pressure to a tooth varies the blood vessels' diameter in the periodontal ligament, which then changes the blood flow. Chemical messengers cause cellular changes as a result, which results in the remodeling of the alveolar bone.

Materials and Methods:

This study was obtained based on literature in journals from Pubmed, Scopus, and Web of Science databases. The review developed a method to determine whether comparable the literature was using the exact keywords before developing findings and then summarizing them into a continuous sequence. The case reports investigated patients who met the inclusion criteria for dental implants and osseointegration. There were 21 journals from PubMed, Scopus, and Web of Science databases. The present review is from research, review, and case report study with eligibility criteria. The review results discovered that according to the “pressure-tension” idea, applying pressure to a tooth modifies the blood flow by altering the periodontal ligament's blood vessel diameter.

Results:

Alveolar bone remodeling results from cellular changes brought on by chemical messengers. Inflammation is the host tissue's defensive reaction to pathogens, injury, or external objects. Vascular dilation, improved capillary permeability, increased blood flow, and leukocyte recruitment are all signs of inflammation. The first cells to arrive at the inflamed region are polymorphonuclear neutrophils. Eicosanoids, a group of hormones that includes prostaglandins, are chemical messengers.

Conclusion:

Several articles have suggested specific compounds as orthodontic tooth movement biomarkers. The creation of biomarkers to comprehend the ongoing biological processes related to orthodontic tooth movement is developing.