bluuebunny/crossref_metadata_2025 huggingface dataset:
Characterization of Fibrodysplasia Ossificans Progessiva relevant Acvr1/Acvr2 Activin receptors in medaka (Oryzias latipes)
Authors: Trumpp Michael , Tan Wen Hui , Burdzinski Wiktor , Basler Yara , Jatzlau Jerome , Knaus Petra , Winkler Christoph
Published: September 2023

Activin and Bone Morphogenetic Protein (BMP) signaling plays crucial roles in vertebrate organ formation, including osteo- and angiogenesis, and tissue homeostasis, such as neuronal maintenance. Activin and BMP signaling needs to be precisely controlled by restricted expression of shared receptors, stoichiometric composition of receptor-complexes and presence of regulatory proteins. A R206H mutation in the human (hs) BMP type I receptor hsACVR1, on the other hand, leads to excessive phosphorylation of Sons of mothers against decapentaplegic (SMAD) 1/5/8. This in turn causes increased inflammation and heterotopic ossification in soft tissues of patients suffering from Fibrodysplasia Ossificans Progressiva (FOP). Several animal models have been established to understand the spontaneous and progressive nature of FOP, but often have inherent limitations. The Japanese medaka (Oryzias latipes,ola) has recently emerged as popular model for bone research. To assess whether medaka is suitable as a potential FOP animal model, we determined the expression ofActivin receptor type I(ACVR1)orthologsolaAcvr1andolaAcvr1lwith that of Activin type II receptorsolaAcvr2ab,olaAcvr2baandolaAcvr2bbin embryonic and adult medaka tissues byin situhybridization. Further, we showed that Activin A binding properties are conserved in olaAcvr2, as are the mechanistic features in the GS-Box of both olaAcvr1 and olaAcvr1l. This consequently leads to FOP-typical elevated SMAD signaling when the medaka type I receptors carry the R206H equivalent FOP mutation. Together, this study therefore provides experimental groundwork needed to establish a unique medaka model to investigate mechanisms underlying FOP.
Hierarchical power control of a large-scale wind farm by using a data-driven optimization method
Authors: Di Pengyu , Xiao Xiaoqing , Pan Feng , Yang Yuyao , Zhang Xiaoshun
Published: September 2023

With the participation in automatic generation control (AGC), a large-scale wind farm should distribute the real-time AGC signal to numerous wind turbines (WTs). This easily leads to an expensive computation for a high-quality dispatch scheme, especially considering the wake effect among WTs. To address this problem, a hierarchical power control (HPC) is constructed based on the geographical layout and electrical connection of all the WTs. Firstly, the real-time AGC signal of the whole wind farm is distributed to multiple decoupled groups in proportion of their regulation capacities. Secondly, the AGC signal of each group is distributed to multiple WTs via the data-driven surrogate-assisted optimization, which can dramatically reduce the computation time with a small number of time-consuming objective evaluations. Besides, a high-quality dispatch scheme can be acquired by the efficient local search based on the dynamic surrogate. The effectiveness of the proposed technique is thoroughly verified with different AGC signals under different wind speeds and directions.
Impaired cerebrovascular reactivity correlates with reduced retinal vessel density in patients with carotid artery stenosis: Cross-sectional, single center study
Authors: Magyar-Stang Rita , István Lilla , Pál Hanga , Csányi Borbála , Gaál Anna , Mihály Zsuzsanna , Czinege Zsófia , Sótonyi Péter , Tamás Horváth , Koller Akos , Bereczki Dániel , Kovács Illés , Debreczeni Róbert
Published: September 2023

Background

The cerebral and retinal circulation systems are developmentally, anatomically, and physiologically interconnected. Thus, we hypothesized that hypoperfusion due to atherosclerotic stenosis of the internal carotid artery (ICA) can result in disturbances of both cerebral and retinal microcirculations. We aimed to characterize parameters indicating cerebrovascular reactivity (CVR) and retinal microvascular density in patients with ICA stenosis, and assess if there is correlation between them.

Methods

In this cross-sectional study the middle cerebral artery (MCA) blood flow velocity was measured by transcranial Doppler (TCD) and, simultaneously, continuous non-invasive arterial blood pressure measurement was performed on the radial artery by applanation tonometry. CVR was assessed based on the response to the common carotid artery compression (CCC) test. The transient hyperemic response ratio (THRR) and cerebral arterial resistance transient hyperemic response ratio (CAR-THRR) were calculated. Optical coherence tomography angiography (OCTA) was used to determine vessel density (VD) on the papilla whole image for all (VDP-WIall) and for small vessels (VDP-WIsmall). The same was done in the peripapillary region: all (VDPPall), and small (VDPPsmall) vessels. The VD of superficial (VDMspf) and deep (VDMdeep) macula was also determined. Significance was accepted when p<0.05.

Results

Twenty-four ICA stenotic patients were evaluated. Both CVR and retinal VD were characterized. There was a significant, negative correlation between CAR-THRR (median = -0.40) and VDPPsmall vessels (median = 52%), as well as between VDPPall vessels (median = 58%), and similar correlation between CAR-THRR and VDP-WIsmall (median = 49.5%) and between VDP-WIall (median = 55%).

Conclusion

The significant correlation between impaired cerebrovascular reactivity and retinal vessel density in patients with ICA stenosis suggests a common mechanism of action. We propose that the combined use of these diagnostic tools (TCD and OCTA) helps to better identify patients with increased ischemic or other cerebrovascular risks.
Social context matters: The role of social support and social norms in support for solidarity in healthcare financing
Authors: Meijer Marloes A. , Brabers Anne E. M. , de Jong Judith D.
Published: September 2023

In many European countries, including the Netherlands, the healthcare system is financed according to the principles of solidarity. It is important, therefore, that public support for solidarity in healthcare financing is sufficient in order to ensure that people remain willing to contribute towards solidarity-based systems. The high willingness to contribute to the healthcare costs of others in the Netherlands suggests that support is generally high. However, there are differences between groups. Previous research has focused on mechanisms at the individual and institutional level to explain these differences. However, people’s social context may also play a role. Little research has been conducted into this. To fill this gap, we examined the role of perceived social support and social norms in order to explain differences in the willingness to contribute to other people’s healthcare costs. In November 2021, we conducted a survey study in which a questionnaire was sent to a representative sample of 1,500 members of the Dutch Healthcare Consumer Panel. This was returned by 837 panel members (56% response rate). Using logistic regression analysis, we showed that people who perceive higher levels of social support are more willing to contribute to the healthcare costs of others. We also found that the willingness to contribute is higher when someone’s social context is more supportive of healthcare systems that are financed according to the principles of solidarity. This effect does not differ between people who perceive low and high levels of social support. Our results suggest that, next to the individual and institutional level, the social context of people has to be taken into consideration in policy and research addressing support for solidarity in healthcare financing.
Identification of Cry toxin receptor genes homologs in a de novo transcriptome of Premnotrypes vorax (Coleoptera: Curculionidae)
Authors: Velásquez C. Luisa-Fernanda , Cantón Pablo Emiliano , Sanchez-Flores Alejandro , Soberón Mario , Bravo Alejandra , Cerón S. Jairo A.
Published: September 2023

The white potato worm Premnotrypes vorax (Hustache) (Coleoptera: Curculionidae) is one of the most destructive insect pests of potato crops in South America. Like many coleopteran insects, P. vorax shows low susceptibility to Cry insecticidal proteins produced by the bacterium Bacillus thuringiensis (Bt). However, the presence of Cry toxin receptors in the midgut of this this insect has never been studied. The main Cry-binding proteins described in other insect species are cadherin (CAD), aminopeptidase N (APN), alkaline phosphatase (ALP) and ATP-binding cassette (ABC) transporters. In this study, we analyzed and validated a de novo assembled transcriptome of Illumina sequencing data to identify and to characterize homologs of Cry toxin receptors. We identified the protein sequences in P. vorax that show high identity with their orthologous sequences of the Cry toxin binding proteins in other coleopteran larvae such as APN, ALP, CAD and ABC transporter. This study provides preliminary identification of putative receptor genes of Cry proteins that would be useful for future studies involving biocontrol of this important potato crop pest.
Compensation of adverse growing media effects on plant growth and morphology by supplemental LED lighting
Authors: Solbach Jan Andreas , Fricke Andreas , Stützel Hartmut
Published: September 2023

There is an increasing interest in alternatives to peat in growing media due to environmental constraints. However, plants grown in peat substitutes often show impaired growth compared to plants grown in peat-based media. Hence, it would be interesting to know whether these deficiencies can be compensated by supplementing other growth factors, e.g. light. The present study aims to investigate the interactive nature between growing media and supplemental lighting on plant growth and morphology, and to examine whether supplemental light emitting diode (LED) lighting may compensate adverse growing media effects. Basil (Ocimum basilicum L.) and Chinese cabbage (Brassica rapa subsp. pekinensis) were grown in different growing media consisting of peat, green compost, coconut pulp, wood fibre, perlite and sphagnum moss under blue, red and far-red supplemental LED lighting. We found significant interactions between growing media and supplemental photosynthetically active radiation (PAR) on plant growth, morphology and development. At low light intensities, peat-based and substituted growing media performed similarly, whereas with increasing light intensities the peat-based growing media significantly outperformed their alternatives. The substrate choice determines the required amount of supplemental light to compensate for adverse growing media effects and the amount varies depending on plant species and season. Thereby, it was indicated that red light alleviates adverse growing media effects best. We also found that far-red light is not effective when background PAR is low and becomes more effective under high background PAR. The implications and prospects of the results are discussed.
Extracellular vesicles as a potential source of tumor-derived DNA in advanced pancreatic cancer
Authors: Lapin Morten , Tjensvoll Kjersti , Nedrebø Karoline , Taksdal Eline , Janssen Hans , Gilje Bjørnar , Nordgård Oddmund
Published: September 2023

Tumor-derived extracellular vesicles (EVs) are reported to contain nucleic acids, including DNA. Several studies have highlighted the potential of EV-derived DNA (evDNA) as a circulating biomarker, even demonstrating that evDNA can outperform cell-free DNA (cfDNA) in terms of sensitivity. Here, we evaluated EVs as a potential source of tumor-derived DNA in patients with advanced pancreatic cancer. evDNA from both DNase-treated and untreated EV samples was analyzed to determine whether the DNA was primarily located internally or outside (surface-bound) the EVs. To assess whether methodology affected the results, we isolated EVs using four different methods for small EV isolation and differential centrifugation for isolating large EVs. Our results indicated that the DNA content of EVs was significantly less than the cfDNA content isolated from the same plasma volume (p < 0.001). Most of the detected evDNA was also located on the outside of the vesicles. Furthermore, the fraction of tumor-derived DNA in EVs was similar to that found in cfDNA. In conclusion, our results suggest that quantification of evDNA, as a source of tumor-derived DNA, does not add information to that obtained with cfDNA, at least not in patients with advanced pancreatic cancer.
Traumatic brain injury and rTMS-ERPs: Case report and literature review
Authors: Fu Yutong , Xu Chunyan , Fan Hong , Yang Xue , Ou Jibing , Yao Liqing , Wang Wenli
Published: September 2023

Currently, there are no cases of targeted, individualized repeated transcranial magnetic stimulation (rTMS) treatment based on event-related potential (ERPs) results showing the activation of functional brain regions. The identification and treatment of mild cognitive impairment after traumatic brain injury are challenging. rTMS has shown unique advantages in previous studies, with positive effects on noninvasive modulation and neuroplasticity after brain injury. The selection of the rTMS parameters and targets remains controversial. ERPs indicate the cortical activity involved in cognitive processing in patients. Therefore, this study proposes that ERPs can be used as biomarkers of cognitive recovery. The results of this study will guide the development of rTMS protocols for patient treatment. To help clinicians better apply rTMS and ERPs in combination, we conducted a relevant literature review and discussion, detailing the therapeutic mechanisms of the combination of ERPs and rTMS. This will facilitate the precise assessment and personalized treatment of such patients, improve the abnormal processing patterns of patients, and promote their return to life and society.
Geopolitical Tensions and Global Monetary (Dis)Order
Authors: Eichengreen Barry
Published: September 2023

Two sources of geopolitical tension – G7 sanctions on Russia and conflict between the United States and China – have the potential to reshape the global monetary system. This short paper argues that only the second is likely to have far-reaching, and heavily negative, consequences if allowed to develop further.
On extremal cacti with respect to the first degree-based entropy
Authors: Li Weimin , Li Jianping , Zhang Jianbin , He Weihua
Published: September 2023

Let

G

G

be a simple graph with degree sequence

D

(

G

)

=

(

d

1

,

d

2

,

…

,

d

n

)

D\left(G)=\left({d}_{1},{d}_{2},\ldots ,{d}_{n})

. The first degree-based entropy of

G

G

is defined as

I

1

(

G

)

=
ln

∑

i
=
1

n

d

i

−

1

∑

i
=
1

n

d

i

∑

i
=
1

n

(

d

i

ln

d

i

)

{I}_{1}\left(G)=\mathrm{ln}{\sum }_{i=1}^{n}{d}_{i}-\frac{1}{{\sum }_{i=1}^{n}{d}_{i}}{\sum }_{i=1}^{n}\left({d}_{i}\mathrm{ln}{d}_{i})

. In this article, we give sharp upper and lower bounds for the first degree-based entropy of graphs in

C

(

n
,
k

)

{\mathcal{C}}\left(n,k)

and characterize the corresponding extremal graphs when each bound is attained, where

C

(

n
,
k

)

{\mathcal{C}}\left(n,k)

is the set of all cacti with

n

n

vertices and

k

k

cycles.
Catalytic oxidative carbon–carbon bond-formations of benzene-1,2-diols
Authors: Sohtome Yoshihiro , Sodeoka Mikiko
Published: September 2023

The cross-dehydrogenative coupling (CDC) reaction has emerged as a powerful synthetic tactic for forging carbon–carbon bonds starting from two nucleophiles. However, the mechanisms underlying this reaction class are complex and not always intuitive. Thus, understanding the key principles to selectively promote the bond-forming event in each CDC reaction is a prominent step for the further development of these reactions. Herein, we focus on the CDC reaction of benzene-1,2-diols (catechols and pyrocatechols), aiming to make the complex bond-forming event more comprehensive. To draw mechanistic views, we divide the reaction types according to the mechanistic difference in the C–C bond-forming event: In the Type I mechanism, the reaction is initiated by oxidation of benzene-1,2-diols to the corresponding 1,2-benzoquinones. In the Type II mechanism, the coupling partner is initially oxidized, and the resulting radical directly couples with benzene-1,2-diols (or their enolate form). According to this mechanistic classification, we first describe the basic features of the quinone redox reaction to discuss the reactivity difference between benzene-1,2-diols and 1,2-benzoquinones. We then present the historical background and state of the art of current CDC reactions starting from benzene-1,2-diols. This mini-review encourages the development of catalytic CDC reactions of benzene-1,2-diols and other substrates.
Prosody influence on (im)politeness perception in Chinese-German intercultural communication
Authors: Cao Jiazhen
Published: September 2023

This paper aims to explore the influences of prosody on (im)politeness perception in intercultural communication. Based on empirical data collected in perceptual experiments, the paper compares the perception of the (im)politeness prosodic properties of L1 German speakers and L2 German speakers of Chinese origin. It was found that the two subject groups show clear distinctions in their (im)politeness perceptions and that prosodic features exert different impacts on (im)politeness perception: L2 German speakers of Chinese origin perceive lower acoustic intensity, more pauses, and lower muscle tension as indicators of higher level of politeness, whereas the opposite holds true for L1 German speakers. In addition, the former demonstrate higher sensitivity to speech rate and modal particle stress than the latter. The study’s findings indicate that (im)politeness and prosody perception are influenced by people’s first language and home-grown culture, and a prosodic mitigation strategy may not be fully applicable in intercultural communication.
Herstellung von zellulären Faltstrukturen aus Blech
Authors: Görz Marcel , Thissen Simon , Clauß Philipp , Rouven Riedmüller Kim , Liewald Mathias , Middendorf Peter
Published: September 2023

Der Beitrag beschreibt die Entwicklung eines Umformwerkzeugs zur Herstellung von Faltstrukturen aus Stahlblechen, welche für Sandwich-Anwendungen eingesetzt werden können. Ausgehend von einer Analyse des Standes der Technik hinsichtlich der Faltkinematik von Faltstrukturen und unterschiedlichen Werkzeugkonzepten wurde ein Werkzeug entwickelt, welches die Herstellung von Faltstrukturen aus Feinblech ermöglicht. Dieser Beitrag verdeutlicht, dass die Herstellung von Faltstrukturen durch das gezielte Biegen von Blechen mit nicht vernachlässigbaren Dicken nur durch die Verwendung eines geeigneten Faltwerkzeugs möglich ist.
Vorgehensmodell für die Kreislaufführung von Elektro- und Elektronikaltgeräten
Authors: Wurster Marco , Kille Vincent , Binding Markus , Lanza Gisela
Published: September 2023

Die Kreislaufführung von Wert- und Stoffströmen kann die negativen Folgen von steigenden Rohstoffkosten und Verfügbarkeitsproblemen in der produzierenden Industrie eindämmen, ist jedoch mit organisatorischen und technischen Herausforderungen verbunden. Im Zuge dieses Beitrags wird ein Vorgehensmodell für eine strukturierte techno-ökonomische Bewertung der Recyclingfähigkeit sowie für eine Demontageplanung von sich im Feld befindlichen Elektro- und Elektronikaltgeräten (EEAG) vorgestellt und anhand des Waschmaschinenrecyclings demonstriert.
Vergleich numerischer Simulationen von Tiegelöfen zur Beschreibung energierelevanter Betriebszustände
Authors: Mages Alexander , Sauer Alexander
Published: September 2023

Mit einem Gesamtenergieverbrauch von 4,2 TWh zählen die Nichteisen-Metallgießereien zu den besonders energieintensiven Branchen. Insbesondere der Prozessschritt Schmelzen benötigt etwa 50 Prozent des Energieverbrauchs. Hierbei können numerische Methoden unterstützen, das Potenzial zu erschließen. Daher wird in diesem Beitrag der Stand der Technik der numerischen Simulationen zur Beschreibung elektrisch widerstands- und brennstoffbeheizter Tiegelöfen hinsichtlich darstellbaren energierelevanten Betriebszuständen eingeordnet und bewertet. Simulationsmodelle nur brennstoffbeheizter Tiegelöfen basieren auf stark vereinfachenden oder unklaren Annahmen, die einzelne Betriebszustände nur grob abbilden. Numerische Simulationsmodelle elektrisch widerstandsbeheizter Schmelzöfen können hingegen Betriebszustände bereits detaillierter abbilden, womit diese zur simulationsbasierten Optimierung besser geeignet sind.
Magyar kormányzati szereplők digitális diplomáciai tevékenysége a Twitteren (2021-2022)
Authors: Péter Kacziba
Published: September 2023

A tanulmány fókuszában a magyar kormányzathoz köthető Twitter-felhasználók 2021 és 2022 közötti tevékenységének empirikus vizsgálata áll. Célja, hogy feltérképezze a platform nemzetközi kommunikáció-ban legaktívabb kormányzati szereplőinek összetételét, megértse az azonosított aktorok tartalomelőállítási szokásait, a közölt narratívák főbb jellemzőit, valamint azok eloszlásának trendjeit. A tanulmányhoz kapcsolódó kutatás utóbbi célkitűzések megvalósítása érdekében önálló adatgyűjtést végzett, a létrejövő adatbázist pedig szoftveres elemzési technikákkal vizsgálta. Az elemzés egy nemzetközi trendeknek megfelelő digitális diplomáciai tevékenységet körvonalazott, amelyben a legaktívabb és leginkább követett résztvevők száma és összetétele ma már viszonylag magas, az emblematikus felhasználók szerepvállalása pedig aktív. Az eredmények egy centralizált rendszer ismérveit mutatják, amelyben a központtól távolodva a relatív kontroll csökken, emiatt az információs és relációs jellegű tartalmak megjelenése, illetve a szereplők közötti eloszlása jobbára kiegyensúlyozott. Ezek a tulajdonságok ugyanakkor csak az átlagot tekintve érvényesek, 2022-től az egyébként nemzetközi kontextusban megjelenő üzenetek tartalmában hangsúlyosabban jelennek meg a belpolitikában használt kommunikációs panelek.
tömegek tébolya
Authors: Ádám Tislér
Published: September 2023

A cancel culture, vagy magyarul „az eltörlés kultúrája” az utóbbi évek egyik legtöbbször vitatott társadalmi jelensége a nyugati országokban. Az online térben végig söprő boszorkányüldözések elől látszólag senki nem rejtőzhet el, ha valaha olyat tett, vagy mondott, ami a társadalmi igazságosságért küzdő csoportok szerint elfogadhatatlan, vagy kívül esik a politikai korrektség határain. Ezek a csoportok nem tűrnek semmiféle ellenvéleményt, dogmatikus módon foglalnak állást, a velük történő konstruktív vitára alig van lehetőség. De mégis mi lehet az oka, hogy ezek a csoportok ilyen sikeresen tudják álláspontjukat érvényesítni a nyugati világban látszólag anélkül, hogy ellenvéleménybe ütköznének?
Microstructure and Physical Properties of Nonmagnesium and Magnesium-Based High-Entropy Alloys: A Comparison Study
Authors: Karnati Kiran Kumar , Punna Eshwaraiah , Somarouthu Prasad V. G. V. A. , Ravuri Balaji Rao
Published: September 2023

In this investigation, (Ti-Mo-Zr)60Co20Cr20, (Ti-Mo-Zr)60Al30Si10 (non-magnesium-based), and (Ti-Mo-Zr)60Cu10Mg30 (magnesium-based) high-entropy alloy (HEA) samples are prepared via mechanical milling and then by spark plasma sintering technique. The microstructure morphology is examined using x-ray diffraction and scanning electron microscopy with energy-dispersive x-ray spectroscopy. The microstructure reveals that there would be a strong correlation between phase structure and sustainability for localized corrosion behavior. The lowest crystallite size of the magnesium-based HEA powder mixture suggests the highest corrosion resistance because of the solid-solution face-centered cubic and body-centered cubic phases for 20 h of milling. The correlation between the microstructural morphology and functional properties such as hardness, corrosion resistance, and potentiodynamic parameters are compared for both magnesium-based and non-magnesium-based HEAs and analyzed to elucidate their suitability for lightweight vehicle applications.
Editorial
Authors: Paula D'Avila Ana
Published: September 2023

Editorial do v. 11, n.19, 2023  Dossiê - Mobilizações sociais na América Latina em tempos de pandemia
A “modernização” da legislação trabalhista
Authors: Foletto Bevilaqua Vinicius
Published: September 2023

O objetivo do artigo é analisar os discursos do setor patronal e industrial sobre a legislação trabalhista em 2003. Para analisar o objeto de estudo, utilizou-se o conceito de “gramática social”, compreendido como o conjunto de críticas e justificações histórica e coletivamente elaborado por grupos sociais ou coletividades em contextos de disputa política. Analisaram-se três audiências públicas ocorridas no Congresso Nacional em 2003 com o auxílio teórico-metodológico da análise do discurso (MAINGUENEAU, 2015) e da análise de conteúdo (SPINK & LIMA, 1999). Como resultado, identificou-se a manifestação discursiva da gramática social da “modernização”. Os locutores do setor patronal e industrial mobilizaram a gramática para legitimar sua visão de mundo e prática política na esfera legislativa. Constatou-se que a noção de “modernização” foi empregada semanticamente de modo distinto quando considerado os quadros patronais e industriais e os quadros político-administrativos do Estado. Conclui-se que a gramática social identificada produz, sobretudo, o efeito discursivo de mascarar a disputa moral entre capital e trabalho através do verniz da “modernização” como sinônimo de competitividade, atualidade, técnica e eficiência.
EDITORIAL
Authors: Centeno Rodrigues Paulo Ricardo
Published: September 2023

Editorial
CARDEAL-DO-BANHADO (Amblyramphus holosericeus)
Authors: Da Silva Zani Gabriel
Published: September 2023

O Amblyramphus holosericeus (Scopoli, 1786), conhecido popularmente como Cardeal-do-banhado, Capitão, Do-re-mi, João-pinto-do-brejo, Soldado, Federal ou Scarlet-headed Blackbird, é uma ave paludícola (habita pântanos ou charcos) muito observada em banhados e juncais da região sul do Brasil. Embora já avistada em Estados do sudeste e centro-oeste do país, como São Paulo, Mato Grosso, Mato Grosso do Sul e Tocantins, sua ocorrência concentra-se no Rio Grande do Sul, Santa Catarina, Paraná e países como Paraguai, Argentina e Uruguai (Figura 1) (TIMM; TIMM, 2016).
Linearly-Additive Decomposed 2 × 2 Games: A Primer for Research
Authors: Kuper-Smith Benjamin James , Korn Christoph W.
Published: September 2023

2 × 2 games (such as the Prisoner’s Dilemma) are economic games for studying cooperation and social decision-making. Linearly-additive decomposed games are variants of 2 × 2 games that can change the framing of the game and thereby provide researchers with additional flexibility for measuring preferences and social cognition that would not be possible with standard (matrix-form) 2 × 2 games. In this paper, we provide a systematic overview of linearly-additive decomposed 2 × 2 games. We show which 2 × 2 games can be decomposed in a linearly-additive way and how to calculate possible decompositions for a given game. We close by suggesting for which experiments decomposed games might be more conducive than matrix games.
Effect of Neem Leaf Extract on Reproductive Potential of Male Rats Fed High-Fat Diet
Authors: Laila Nur , Sitasiwi Agung Janika , Isdadiyanto Sri
Published: September 2023

Neem leaves contain bioactive compounds, including tannins, saponins, flavonoids, alkaloids, and terpenoids which are thought to have a cholesterol-lowering effect, but are also accompanied by antifertility effects. This study aims to determine the effect of neem leaf ethanol extract on the structure and reproduction of hyper-cholesterol or hyperlipidaemic male rats. The study used a completely randomized design which was divided into 6 groups with 4 repetitions, namely: P0 (negative control), P1 (positive control), P2 (8 mg/gBW simvastatin), P3, P4, and P5 (75, 100, and 125 mg/gBWof neem leaf extract). Parameters observed were testicular structure (epithelial thickness and seminiferous tubule diameter), GSI, ESI, epididymal protein expression and concentration, morphology and number of spermatozoa. Exposure to ethanolic extract of neem leaves had a significant effect on seminiferous tubule diameter, morphology and number of spermatozoa in white rats fed a high-fat diet, but did not differ significantly on the thickness of the seminiferous tubule epithelium and GSI, so it can be concluded that the effect of ethanolic extract of neem leaves in hypercholesterolemic rats decreased the structure and function of male reproduction as indicated by spermatozoa morphology, spermatozoa number, epididymal protein expression, and testicular structure, supported by the results of protein concentration, GSI, and ESI.
Entrepreneurship-Based Biotechnology E-Module Development to Improve Critical and Creative Thinking Skills
Authors: Aliyah Soimatun , Widiyatmoko Arif
Published: September 2023

Courageous learning triggers learning loss, which is characterized by a decrease in the ability to think critically and creatively. The solution used with innovation in learning media is the e-model of entrepreneurship. This study aims to test the feasibility of entrepreneurship-based biotechnology e-modules and improve students' critical and creative thinking skills after using this e-module. This research and development (RD), which applies the 4D model (Define, Design, Develop, and Dissemination). The study consisted of 31 class IXA students of yunior high school.  The research instrument consisted of expert validation questionnaires, pretest-posttest questions, and student response questionnaires. The analysis of the validation questionnaire for material and media experts produced an average score quite high with the appropriate criteria for use in classroom learning. The results of the t-test for students' critical and creative thinking skills yield a significant value of 0.0 which is smaller than 0.05, which means that there is a significant difference between students' critical and creative thinking skills in the pretest and post-test. Analysis of the N-gain value of students' critical and creative thinking abilities shows an average result of 0.46. This result is included in the category of moderate improvement, which means that the increase in students' critical and creative thinking skills is in the medium category. This e-module also has a very good response from all students.  Based on the results of these analyses, the entrepreneurship-based biotechnology e-module is declared feasible for use in learning and can improve students' critical and creative thinking abilities.
Termite Identification Attacks on Buildings
Authors: Subekti Niken , Fadhila Anita
Published: September 2023

House construction continues from time to time, the frequency of termite attacks on buildings in the area is also very high due to the disturbance of the termite's natural habitat. Termites target the structural wood of buildings and objects derived from cellulose. This study aims to analyze the diversity of termite, house component damage, the relationship between the age and condition of building in Jakarta, Indonesia . This study used a purposive sampling method from 134 houses in Jakarta, Indonesia with a cross-sectional approach. The research procedures included taking and identifying specimens, analyze the intensity percentage of building damage, analyze the relationship between the age of the building and the condition of the building, and environmental factors. Based on the results of research conducted on 134 houses in Jakarta, it is concluded that there are four types of termites in the study sites: C. curvignathus (61.14%), M. gilvus (18.65%), M. inspiratus (10.88%), and C. cynocephaus (9.33%). The worst damage to residential components is found in the sills. Based on statistical tests, there is a correlation between age and the condition of the building. It indicates that the age of the building is significantly related to its condition.
Mollerstadt’s Future: Urban Design as Part of Trans-Disciplinary Research
Authors: Schmeing Astrid
Published: September 2023

S:ne (Systeminnovation nachhaltige Entwicklung) is a transformation/research project funded by the German government. It aims at sustainable development, including the reduction of CO2. One project’s task looks at future-oriented urban development with the example of “Mollerstadt”, which is part of Darmstadt’s city center. There are several focus areas in this project concerning building, energy, mobility, and consumption. These are not necessarily viewed from an integrative spatial perspective or in relation to urban design. Next to other seminars and projects which I have taught, my colleagues and I (Prof. Henning Baurmann, Vertr.-Prof. Ulrike Franke, Prof. Jan Kliebe, Prof. Joachim Raab, Prof. Alexander Reichel, Prof. Astrid Schmeing, Vertr. Prof. Michael Schröder and several lecturers) have worked with 190 third-year students on integrative urban designs addressing s:ne’s themes. These designs reveal focus areas (building, energy, mobility, consumption) that have an aesthetic and cultural dimension. In order to enhance public discourse and to participate in the transformative process, these student designs have been presented to a wider public in the Schader-Stiftung.
Rational Procedure in the Design of Bridges Using Pre-stressed Concrete Beams — A Theoretical Practical Method in Search of Sustainable Structures
Authors: Corté Abel Noé Xochicale
Published: September 2023

Currently there is not a direct procedure for the design for this system of bridges, according to methods approved by the respective authorities, the procedure is still based on trial and error, there are no studies that give us both the optimal number of girders or the other characteristics of this type of structures like the right thickness of slab or proper resistance, taking into account the concept of optimization, which supports the idea of sustainability and more environmentally friendly designs, the idea of applying this concept to the design of bridges based on pre-stressed concrete beams, which are an integral part of the road network of most countries around the world. Knowing also that concrete is the most produced material by man and that without it would be difficult to understand our current world, due to its own characteristics that make it unique if it is a matter of sustainability, however, its production requires energy and consumption of materials, that is why an optimal design of a superstructure will lead to the minimum consumption of materials while obtaining a design more friendly to nature. It is a global necessity to obtain and deliver concrete structures that meet sustainability conditions.
After the Earthquake: The Resilience of the Territories and Communities in the Emilia Romagna Crater
Authors:   Department of Architecture, University of Ferrara, Italy, Alberti Francesco
Published: September 2023

Almost ten years after the 2012 earthquake in Emilia Romagna, which devastated the municipalities of the crater, we can begin to evaluate the effects of a reconstruction process that begins to restore a new landscape and a new urban image. The reconstruction plans have taken on an unprecedented multilevel and multidisciplinary structure, an integrated territorial project that seeks to overcome the drama of the disastrous event by seizing the opportunity for socio-economic revitalization and for the safety of the settlements affected by the earthquake.
The Extinguishing Democratic State of Law — The Collapse Environment and Society Without “Tomorrow”
Authors:   Faculty of Law at PUC-Campinas, Brazil, Vianna Thaís Romera
Published: September 2023

The main objective of this article is to discuss and examine the rise of neoliberal public policies proposed by the current Brazilian Executive Branch, which favor specific layers aiming at particular and strictly economic interests, threatening in existential plan the life of those who occupy and need the environment through measures inconsistent with the Brazilian jurisdiction of flexibilization of protection policies, in emphasis, the environmental. In this way, the repercussions of these attitudes over time are evident and show themselves to be harmful, not only in the socio-environmental plan but also in the political and regimental structure itself, compromising and putting in jeopardy the directives of the Democratic State of Law in Brazil in the light of the Constitution of the Federative Republic of 1988 and of the international human rights charters to which the country is a signatory. The qualitative methodology will be employed, promoting a complex amount of information in its multiple facets and of the monographic procedure with a bibliographical survey in the fields of Law and Social Sciences. With this, the research brings reflections on the Sustainable Development Goals (SDGs) in the UN’s 2030 Agenda and the rupture of this path with structural reforms that are based on the regression, violation of rights, destruction of ecosystems with the very backing of the State or its omission, signaling the extreme urgency of changes for the sake of a future showing that there cannot be the exercise of citizenship and the affirmation of human rights where there is no democracy, which is based on the harmonization of the will of the majority and, especially, in the protection and respect for minorities, as well as there cannot be a human life without adequacy of the capitalist model in the molds of projects aimed at environmental sustainability. Therefore, having as a foundation the defense of the international and constitutional charters, the Social State, and the foundations of a fair, sustainable and egalitarian society. With this, the present study brings into evidence the current social reality in decline and the negligence in the face of environmental problems in conjunction with the anti-democratic attitudes of a country like Brazil, which is going through a moment of uncertainty and without expectation in the governmental summit itself, which requires reflection and debates for the implementation of public policies with measures to prevent the collapse of biodiversity, of the people and fauna that occupy these spaces and, finally, ensuring sustainable development in a fair way aiming not only at the survival of biosystems and living beings but in cooperation for the progress of mankind within a system that cherishes all forms of life.
Design of Circularly Polarized Microstrip Antenna with slotted Split ring array for Video Surveillance Applications at C-Band
Authors: Srivastava Shipra , Gupta Saptarshi , Sachan Vibhav Kumar , Srikant Satya Sai
Published: September 2023

: It has been observed that the circularly polarized antenna always play an important role in modern wireless communication applications. One of such applications is Video surveillance system. Such system interfaced with circularly polarized antenna during natural calamities, which plays a crucial and important role in rescuing the survivors. The weather conditions make it hard to achieve effective communication between the surveillance equipment and the controller. The applications of rescuing vehicle/boat movement during flood-affected areas required an uninterrupted wireless connectivity, for which polarized antennas are very much required. The present paper investigates this problem by designing an efficient circularly polarised antenna on metasurface material consisting of split ring resonator. The designed antenna is designed to operate in the frequency range of 7.1-7.23 GHz. FR4 glass epoxy material is used as an antenna substrate with dielectric constant 4 and thickness of 1.6mm. An array of split ring resonators etched microstrip antenna was fabricated on FR4 glass epoxy substrate. The result obtained with such a microwave antenna produces an excellent gain of 7.4 dB and return loss of 17.7dB with a bandwidth of 1.2 GHz. Future studies are still in progress.
Algae distribution according to locality in saline coastal water bodies of the Pryazov National Nature Park (Ukraine)
Authors: Bren O.G. , Podorozhny S.M. , Bren O.A. , Solonenko A.M.
Published: September 2023

The study focuses on the distribution of algae in the saline coastal water bodies of the Pryazov National Nature Park according to their habitat preferences. The research revealed that aquatic species form the basis of algal flora. Among them, diatoms are predominant in terms of species richness and frequency of occurrence. In the lake type estuaries and ephemeral water bodies, an increased number of amphibious species was found, which can be attributed to the varying inundation conditions of these water bodies. Among the amphibious species Cyanoprokaryota representatives dominate. Hierarchical clustering of the water bodies demonstrated a connection between the species composition of algae and the type of water bodies, which is consistent with their genesis and transformation.
Pithophora roettleri (Roth) Wittrock – new record in the territory of Ukraine
Authors: Burova O.V.
Published: September 2023

The paper deals with the record of Pithophora roettleri (Roth) Wittrock in Ukraine. The filaments of the species were found in a pond in the Feofania Park in Kyiv, where they were present in small quantities in metaphyton in a sterile condition. The reproductive stages (akinets) which are required for identifying these filaments to the generic and species levels were obtained during storage of the selected sample under room conditions. A morphological description of the identified specimens, photomicrographs, characteristics of location are given. The general distribution of the species was analyzed. The genus Pithophora Wittrock is thermophilic, widespread in subtropics and tropics. Its growth in the temperate climate zone is atypical. Our record is the second one from the territory of Ukraine, as well as one of the northernmost locations of this species in reservoirs without artificial water heating.
Transkribus in Practice: Abbreviations
Authors: Griffiths Rachael
Published: September 2023

This paper discusses the practical considerations and strategies employed in dealing with abbreviations during the transcription of Tibetan cursive (dbu med) manuscripts. Addressing the challenge of varied and complex abbreviations, it explores options for transcription and presents our project’s approach to tagging and recording abbreviations, offering insights into handling these challenges within Transkribus.
Por que me tornei um físico
Authors: Oliveira Antônio Nunes de , Menezes José Wally Mendonça
Published: September 2023

A Física é uma Ciência que, pela sua amplitude e abrangência, traz conhecimentos indispensáveis para o avanço de diversas áreas do conhecimento humano e da tecnologia. Mesmo sendo uma área tão importante, não se tem conseguido atrair tantos jovens para a Física; tanto é verdade que as turmas de licenciaturas em Física são extremamente pequenas, mesmo quando comparadas às de Matemática, cuja procura também é reduzida. Esta pesquisa, de natureza quali-quantitativa, investigou o que tem motivado as pessoas a se decidirem pela Física como profissão e a construírem suas trajetórias na área. A coleta de dados, realizada através da análise de conteúdo das entrevistas conduzidas por ocasião do Dia do Físico (2020), permitiu constatar que as principais motivações que levaram os entrevistados a se tornarem físicos foram: curiosidade científica; divulgação científica, jogos, brinquedos e experimentos científicos; a ponte que a Física estabelece com outras áreas do conhecimento, além do incentivo financeiro, das olimpíadas científicas e dos programas governamentais e projetos de extensão universitária. Todas as motivações citadas ganham reforço com a presença de professores inspiradores, cujas principais características são a didática, o domínio do conteúdo, o aspecto humano e acolhedor, a paixão pelo ensino, além da capacidade de relacionar a Ciência com o cotidiano dos estudantes.
Um olhar sobre as mudanças e os desafios para a implementação das Diretrizes Curriculares Nacionais de 2019 nos cursos de engenharia
Authors: Telles Fabio
Published: September 2023

A organização curricular dos cursos de graduação é fundamentada nas Diretrizes Curriculares Nacionais (DCNs) propostas pelo Conselho Nacional de Educação. Em abril de 2019, foram instituídas novas diretrizes para os cursos de graduação em engenharia. Tendo isso em vista, este artigo buscou avaliar as mudanças apresentadas na nova resolução, a fim de verificar as principais adequações que os cursos de engenharia precisam realizar em seus currículos para alinharem-se às novas diretrizes. Para isso, realizou-se uma pesquisa bibliográfica e documental, utilizando-se da legislação pertinente para verificar as alterações previstas, bem como de artigos e livros para a discussão de aspectos relevantes. O estudo mostrou que as novas DCNs trazem várias alterações importantes com vistas a adequar os cursos ao contexto atual da engenharia. Alguns desafios para a readequação dos currículos e críticas ao direcionamento dado pelas diretrizes também foram analisados à luz da literatura. Espera-se que os apontamentos relatados por esta pesquisa auxiliem no esclarecimento dos pontos mais importantes das novas diretrizes curriculares dos cursos de engenharia.
GARRAFINHA DE REFRIGERANTE, O RELÓGIO DE PAPEL E A FORCA
Authors: Lima Andressa , Oliveira Danilo de Araujo
Published: September 2023

O presente artigo parte da seguinte questão: como o brincar possibilita o aprender a partir de experiências que as crianças criam para fugir das rotinas e prescrições do currículo? Para trazer problematizações a partir dessa pergunta desenvolvemos uma investigação com inspiração etnográfica de perspectiva pós-crítica em uma escola pública municipal. O argumento desenvolvido aqui é o de que as crianças experimentam, inventam e criam maneiras de brincar para fugir da rotina dos currículos escolares, e assim, aprendem brincando e brincam aprendendo. A partir das experiências que as próprias crianças se expõem, entendemos que ao nos expormos aos afetos bons que elas nos permitem ter, precisamos também, como docentes, inventar outros tempos, intervalos, durações, extensões para proliferar o aprender nos currículos escolares, que escapem da rigidez e do controle dados pelas prescrições normativas que constituem muitos currículos.
EXPERIMENTAR E INVENTAR MOVIMENTOS CURRICULARES POR UMA VIDA BONITA
Authors: Gabriel Andrea dos Santos , Silva Sandra Kretli da
Published: September 2023

Este texto compõe uma pesquisa de mestrado que cartografa movimentos de micropolíticas ativas, em uma escola de ensino fundamental, para problematizar os movimentos curriculares inventivos que podem ser produzidos nessa relação. Dialoga com Deleuze e Guattari (2011, 2018) para pensar a educação de outro modo, na perspectiva da criação. Aposta na arte entrelaçada aos currículos como possibilidade de transportar a outros possíveis e na cartografia, como metodologia, para problematizar: que movimentos curriculares inventivos corpos coletivos podem constituir na intenção de afirmar uma vida bonita no cotidiano escolar? Argumenta que, entre formas e forças que operam no cotidiano escolar, há processos de resistência de afirmação da vida. Conclui (sempre aberto ao novo) que é possível sim apostar na escola como corpo coletivo, pois entre macro/micropolíticas, há criação de movimentos curriculares inventivos que escapam aos padrões hegemônicos instituídos e afirmam uma vida bonita no cotidiano escolar.