bluuebunny/crossref_metadata_2025 huggingface dataset:
STUDI PEMODELAN OPTIMASI TUAS HANDLE REM DEPAN SEPEDA MOTOR YAMAHA V-IXION BERBASIS SIMULASI ELEMEN HINGGA
Authors: Supriyanto Supriyanto , Syafa’at Imam , Darmanto Darmanto
Published: November 2020

Sepeda motor merupakan salah satu pilihan masyarakat dalam berpergian. Sepeda motor merupakan salah satu jenis kendaraan yang banyak dipilih masyarakat sebagai moda transportasi di zaman modern saat ini. Salah satu jenis sepeda motor tersebut adalah produk Yamaha V-Ixion yang memiliki tampilan bagus. Handle merupakan komponen pada sepeda motor Yamaha V-Ixion yang berfungsi sebagai tuas pengereman terbuat dari material aluminium. Tujuan dari penelitian ini untuk mengetahui tegangan von mises, defleksi, faktor keamanan dan optimasi pada handle. Pada pemodelan menggunakan bantuan Autodesk Inventor Profesional 2014. Material yang digunakan Aluminium 6061 AHC. Pada simulasi dilakukan pembebanan motor jatuh kesamping, setelah melakukan simulasi pembebanan motor jatuh kesamping berisiko besar rawan patah. Pemodelan asli didapatkan tegangan von mises 474,3 MPa, defleksi 2,314 mm, faktor keamanan 0,58. Setelah dilakukan optimasi ketebalan menjadi 2 mm pada area yang rawan kegagalan (patah) untuk mendapatkan hasil faktor keamanan menjadi 1.21 maka handle aman digunakan.

Kata kunci: defleksi, faktor keamanan, handle,optimasi, tegangan
MATRIX METALOPROTEINASE-2 AND PLACENTARY DYSFUNCTION DEVELOPMENT IN PREGNANCY WITH PERINATAL INFECTIONS
Authors: Vygivska Lyudmila A.
Published: November 2020

Introduction: The search for a statistically significant link between sFasL and their potential regulators MMP-2 is necessary to optimize the tactics of managing and treating pregnant women with perinatal infections.
The aim: To determine the level of MMP-2 in pregnant with perinatal infections and its role in the development of placental dysfunction.
Materials and methods: The study involved examination of 230 pregnant, who were divided into 3 groups (60 people each): Group I with viral (CMV, HSV-1,2,6 types), Group II with bacterial (chlamydia, ureaplasma, mycoplasma) and Group III with mixed infection. Group IV was the control one, and included 50 pregnant with a physiological course of pregnancy. The study implied determination of serum levels of MMP-2 and sFasL, the level of caspase-3 in the placenta, ultrasound was performed by the MINDRAY M7 (China) scanner. The data obtained were statistically processed using the STATISTICA software.
Results: Pregnant women with perinatal infection were found to have a significant increase in sFasL and caspase-3 levels in all the studied groups as compared to corresponding values in the control group (Kruskal-Wallis test, p<0.001). In all groups of pregnant women with perinatal infection the level of MMP-2 in serum was elevated with respect to control values approximately 3-4 times (Kruskal-Wallis test, p <0.05). According to ultrasound data, hypoplasia of placenta was observed in (46.6 ± 6.4)% of cases in Group І and in (30 ± 6.4)% in Group ІІІ. In Groups II and III, placental hyperplasia was detected in (20 ± 5.2)% and (26 ± 5.7)% of cases, respectively.
Conclusions: The findings showed that secondary to the impact of perinatal infection among a number of indices in the peripheral blood of pregnant women, a significant role is played by an increase in levels of MMP-2 and sFasL. These indices reflect and determine the induction of apoptotic response from the placenta in this category of pregnant women. The revealed increase in caspase-3 level means that pregnant women with perinatal infections undergo caspase cascade of apoptosis in placental cells. Thus, the obtained results indicate that pregnant women with perinatal infections develop an increase in the level of MMP-2 and activation of the Fas-dependent signaling pathway of programmed cell death, which leads to the launch of a caspase cascade of apoptosis in placental cells. An increase in the loss of placental cells due to apoptosis may be one of the key factors triggering the development of placental dysfunction and, as a consequence, unfavorable conditions for fetal development.
CONDITION OF HEMODYNAMICS IN THE PULMONARY CIRCULATION OF PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) CONCURRENT WITH METABOLIC SYNDROME WITH HYPERTROPHY AND ATROPHY OF THE MYOCARDIUM
Authors: Boriak Viktor P. , Shut’ Svitlana V. , Trybrat Tetiana A. , Filatova Olena V.
Published: November 2020

Introduction: In recent years, COPD is observed as not an isolated, but an associated pathology, in particular, concurrent with metabolic syndrome.
The aim of the research is to identify the differences in changes of the rheopulmonography parameters (RPG) depending on the presence of hypertrophy or atrophy of the right
ventricular myocardium in patients with COPD concurrent with metabolic syndrome..
Materials and methods: We studied changes in rheopulmonography (RPG) in 145 patients with chronic obstructive pulmonary disease (COPD) concurrent with metabolic syndrome.
Results: We detected precapillary hypertension of the pulmonary circulation in patients with right ventricular myocardial hypertrophy: anacrotism serration; flattened peak of
the systolic wave; decreased Vcp; high placement of incisura; horizontal course of catacrotism; decreased amplitude of the systolic wave (in this case, due to a greater increase in the resistance of the blood flow in the pulmonary vessels than the decreased impact volume of the right ventricle); prolonged Q-a (in this group of patients, it depends more
on hypertension of the pulmonary circulation than on the reduction of contractile function of the myocardium).
In atrophy of the right ventricular myocardium, the following changes in the RPG were revealed: decreased systolic wave at its dramatic rise; prolonged Q-a (in this case, due to the weakened heart contraction); Vmax reduction (it reflects the reduction of myocardial contractility); in hypertrophy of the myocardium, Vcp., unlike RPG, does not decrease,
which is explained by the decrease in the pressure of the pulmonary circulation.
Conclusions: We believe that these changes in RPG allow differentiating hypertrophy and right ventricular myocardial atrophy along with established diagnostic criteria, and
can be used as markers for the diagnosis and treatment of COPD concurrent with metabolic syndrome.
FACTS AND SPECULATIONS ON VITAMIN D IN PREVENTION AND TREATMENT OF ATOPIC DERMATITIS
Authors: Lis-Święty Anna , Milewska-Wróbel Dorota
Published: November 2020

Recently, age- and weight-specific recommendations for prevention, supplementation and treatment of vitamin D (VD) deficiency in the general population and in groups
at increased risk of the deficiency (i.a. atopic dermatitis) has been presented by the Polish Experts group. VD regulates many physiological processes in the skin ranging from cellular proliferation, differentiation, and apoptosis to barrier maintenance and immune functions. VD deficiency has been associated with increased incidence and severity of atopic dermatitis. In addition, VD supplementation was shown to decrease atopic dermatitis severity in several studies, but the findings obtained in systematic reviews and meta-analyses are controversial.
PILONIDAL DISEASE: CHANGES IN UNDERSTANDING OF ETIOLOGY, PATHOGENESIS AND APPROACH TO TREATMENT
Authors: Konoplitskyi Viktor , Shavliuk Ruslan , Dmytriiev Dmytro , Dmytriiev Kostiantyn , Kyrychenko Oleksii , Zaletskyi Bohdan , Olkhomiak Oleksandr
Published: November 2020

Data from Web of Science, SCOPUS, Pub Med, Medline, E-library, and other sources was used in writing this article. The main focus was directed towards literature written in
English. The selection of literature was based on such concepts as: etiopathogenesis, historical principles of treatment, methods of surgical and non-surgical intervention. Data
from metanalysis publications and randomized clinical trials pertaining to the treatment of the pilonidal sinus at various stages of its formation was used, as well.
Ukrainian Theater Actresses in Eastern Galicia
Authors: Rosa-Lavrentii Sofiia
Published: November 2020

This article offers a typology of the experiences of Ukrainian theater actresses in Eastern Galicia from the end of the 19th to the first half of the 20th centuries, identifying the most common artistic and biographical trajectories that make up the particular continuities of women’s collective cultural experience. The “images” of these Ukrainian actress are delineated according to how they were constructed by the contemporary Ukrainian press, and their peculiarities are identified in accordance with the specifics of the activities of Ukrainian theater in Eastern Galicia during the period in question. (Transl. S. Harbuziuk)
Returning the Other
Authors: Harbuziuk Maiia
Published: November 2020

The author reviews Nataliya Yakubova’s monograph Irena Solska: The Burden of Unusualness (Moscow 2019) which is the result of more than ten years of work. Yakubova emphasizes that for her the past remains an “open project” to which one can (and should) return many times and her book can be seen as such “portal to the past”. The creative and life path of Irena Solska was chosen as the object of research, and its subject was defined as the “burden of unusualness” of the actress’s personality. Yakubova sees the main analytical problem in the conservation of social stereotypes about Irena Solska and diagnoses the fundamental bias, spread in Polish culture, of the myth of Irena Solska as a “demonic woman”. Therefore, the purpose of the study was the interpretation of sources, the destruction of stereotypes, and overcoming patterns of representations. The principle of interdisciplinary research allows her to consider the fate of the star actress as a phenomenon of her time, in the dynamics of complex socio-political, socio-cultural, aesthetic-technological and ideological-emancipatory changes from the late nineteenth century to the late 1930s. (Transl. S. Harbuziuk)
Pemanfaatan Web Sebagai Sistem Informasi PPDB pada SLBN Koba Bangka Tengah
Authors: Sari Lili Indah
Published: November 2020

Pendidikan merupakan kebutuhan dasar setiap manusia. Anak-anak yang memiliki perbedaan kemampuan (difabel) disediakan fasilitas pendidikan khusus di sesuaikan dengan derajat dan jenis difabelnya yang disebut dengan Sekolah Luar Biasa (SLB).Sekolah Luar Biasa adalah sebuah lembaga pendidikan formal yang melayani pendidikan bagi anak-anak berkebutuhan khusus.  Sekolah Luara Biasa Negeri Koba merupakan salah satu sekolah berkebutuhan khusus yang ada di kabupaten Bangka Tengah yaitu di daerah Koba. SLBN Koba merupakan satu satunya SLB Negeri yang ada di Kabupaten, hal ini akan berpengaruh pada penerimaan peserta didik baru (PPDB) yang ada di SLBN, karena letaknya yang jauh dan terpencil. Pada saat PPDB orang tua atau wali murid harus datang dan daftar langsung ke sekolah tersebut. Hal ini akan merepotkan karena harus bolak balik kesekolah, ditambah sistem PPDB yang ada di SLBN Koba masih dilakukan secara manual. Oleh karena itu, Dengan adanya masalah yang ada di atas maka penulis ingin membuat suatu Sistem Penerimaan Peserta Didik Baru bertujuan untuk mempermudah orang tua siswa dalam pendaftaran PPDB dan sekolah SLBN dalam pengolaan data  siswa baru yang diperlukan. Dalam hal ini penulis menggunakan model waterfall  dan tool yang akan digunakan untuk merancang sistem ini menggunakan Unified Modelling Languange (UML).
Gestion paramédicale de l’échange plasmatique
Authors: Bougonna Yanis , Ritzenthaler Thomas , Bodonian Carole
Published: November 2020

L’échange plasmatique est une technique d’aphérèse thérapeutique qui permet soit d’éliminer une substance pathogène du sang, soit d’apporter une substance manquante, soit d’obtenir des effets immunomodulateurs, par séparation du plasma des autres composés du sang, grâce à un circuit de circulation extracorporelle. Le branchement, la surveillance et le débranchement d’un circuit d’échanges plasmatiques correspondent à un acte infirmier réalisé sur prescription médicale, dépendant de l’article R4311-7 du code de la santé publique. L’objectif de cet article est de revoir les indications de l’échange plasmatique en réanimation, les différentes techniques utilisées, ainsi que la surveillance des complications et leur prévention.
Intérêt de l'échographie dans la prise en charge des dyspnées en urgence
Authors: Bobbia Xavier , Markarian Thibaut
Published: November 2020

La dyspnée est un motif de prise en charge fréquent en médecine d’urgence. Il y a une relation entre la mise en place du bon traitement étiologique et la morbi-mortalité. Le diagnostic étiologique est souvent cliniquement complexe, en particulier chez les patients âgés. L’échographie pulmonaire permet une excellente analyse lésionnelle pulmonaire. L’échocardiographie transthoracique permet souvent d’en comprendre le mécanisme. L’échographie de compression veineuse des membres inférieurs a un rôle dans la recherche d’embolie pulmonaire. L’articulation de ces outils avec l’examen clinique permet d’améliorer la pertinence clinique du médecin confronté à une situation de dyspnée aigue. L’échographie peut également avoir un rôle d’aide au triage des patients dyspnéiques. Une bonne connaissance des différents syndromes échographiques et de leur intégration dans le raisonnement diagnostique par tous les praticiens est nécessaire à l’amélioration de la prise en charge de ces patients.
The Relationship Between Credit Risk
Management and the Profitability of Banks
in Ghana
Authors: Owusu-Boafo Roger , Obeng Ernest , Addo Jone Yeobah
Published: November 2020

Banks are faced with several types of risks. Prominent among these risks is credit risk.
Profitability is key to the growth and survival of banks. This study therefore seeks to investigate
the relationship that exists between credit risk and the profitability of banks in Ghana. To
achieve this objective, eight banks were sampled out of a population of twenty nine (29)
banks over a ten (10) year period from 2005 to 2014. A panel regression was run using Return
on assets (dependent variable) as a proxy for profitability while non-performing loan ratio
and net charge oﬀ to total loans and advances (independent variables) were used as proxies
for credit risk. Other variables such as size, growth and debt ratio which inﬂuence profitability
were controlled for in the model. Secondary data comprising annual reports of the selected
banks was used for the study. The study established a positive and significant relationship
between credit risk and the profitability of banks in Ghana. This implies that banks in Ghana
enjoy profit in the midst of all the credit risk. The study also confirmed the findings of previous
studies that, size and debt ratio are factors that inﬂuence profitability as there was a positive
and significant relationship with profitability.
Presenting Trends In Petrochemical Process Control Systems
Authors: Farris Kellee , Ganapathy Subhashini , Fendley Mary
Published: November 2020

Petrochemical operators view the distributed control system process through operating graphics that are displayed on four or more cathode ray tube displays that are monitored 24/7. The graphics vary in both design and content, however there has not been extensive research done on the ability of vector arrows to display this trend information. The purpose of this study was to understand the current trend representation methods and to develop efficient trend representation displays. Results indicate that providing vector arrows for trend representation can be effective in getting the attention of the user and can help in reducing change blindness. Results also indicate that between 10 and 20 degrees of change a participant notices change and that any rate of change increase beyond that does not improve their recognition, illustrating the importance of capturing the rate of change within this range in representing trend data. We were able to demonstrate that use of vector arrows for at-a-glance initial trend analysis was easy to use and effective in petrochemical industry systems.
Hernia umbilicalis pagrindinių gydymo būdų palyginimas. Literatūros apžvalga
Authors: Savonytė Agnė
Published: November 2020

Planinės išvaržų operacijos yra vienos dažniausių operacijų, atliekamų šiandien pasaulyje. Pilvo išvaržas turi apie 4–5 proc. gyventojų. Galimas konservatyvus ir chirurginis bambinių išvaržų gydymas. Pašalinti išvaržą galima tik chirurginiu būdu. Kokią operaciją renkamasi, priklauso nuo išvaržos dydžio, lokalizacijos ir nuo to, ar išvarža pasikartojanti. Žmogaus sveikata, amžius, anestezijos rizika, chirurgo patirtis taip pat yra svarbūs veiksniai. Esant bambos išvaržai, operacija, naudojant tinklelį, yra tinkamesnė nei audinių susiuvimas dėlmažesnio išvaržų pasikartojimo dažnio.Operuojant laparoskopiškai, geresnis klinikinis poveikis: mažesnė infekcijos rizika, mažesnės komplikacijos, greitesnis sveikimas. Šiame straipsnyje aprašyta surinkta informacija apie bambinių išvaržų gydymo aspektus. Pasitelkiant straipsniuose aprašoma įvairių metodikų rezultatų kokybe ir populiarumu, duomenys buvo palyginti tarpusavyje. Apžvelgti svarbiausi bambinės išvaržos gydymometodai ir įmanomos komplikacijos, susijusios su šia liga arba jos gydymu.
Kandidemija – reta kraujo infekcija
Authors: Kazlauskas Ovidijus , Mažeikaitė Aistė , Lukoševičienė Rima , Unikauskas Alvydas
Published: November 2020

Kandidemija – tai auganti problema sveikatos sistemoje [5]. „Auksiniu standartu“ diagnostikoje išlieka kraujo pasėlis [10], tačiau kuriami nauji diagnostikos metodai, kurie padės pagreitinti diagnostiką [12]. Atlikus kraujo pasėlio tyrimą ir patvirtinus kandidemiją, rekomenduojama skirti empirinį priešgrybelinį gydymą [13]. Straipsnyje aprašomas 66metų paciento, kuriam diagnozuota kandidemija, ir gydyto Kauno klinikinės ligoninės Vidaus ligų diagnostikos skyriuje, atvejis.
The Synthesis of Chiral β-Naphthyl-β-Sulfanyl Ketones via Enantioselective Sulfa-Michael Reaction in the Presence of a Bifunctional Cinchona/Sulfonamide Organocatalyst
Authors: Tözendemir Deniz , Tanyeli Cihangir
Published: November 2020

Cinchona alkaloid derived organocatalysts are widely employed in various asymmetric transformations, yielding products with high enantiopurity. In this respect, a bifunctional quinine derived sulfonamide organocatalyst was developed to catalyze the asymmetric sulfa-Michael reaction of naphthalene-1-thiol with trans-chalcone derivatives. The target sulfa-Michael adducts were obtained with up to 96% ee under mild conditions and with a low (1 mol%) catalyst loading. Selected enantiomerically enriched SMA products were subjected to oxidation to obtain corresponding sulfones.
THE EFFECT OF 3,4-DIMETHOXYCINNAMIC ACID DERIVATIVES ON PATHOLOGICAL AGGREGATION OF ALPHA-SYNUCLEIN
Authors: Barinova К. , Melnikova А. , Мuronetz V.
Published: November 2020

3,4-dimethoxycinnamic acid (3,4-DMCA) derivatives were tested for their ability to inhibit the aggregation of α-synuclein. It was shown that the most effective inhibitors among the selected ones are ferulic, 3-methoxy-4- acetamidoxycinnamic, 3,4-DMCA, the rest of the compounds have imperceptible effect on the aggregation.
COMPARATIVE PRODUCTION EFFICIENCY EVALUATION OF ADENO- ASSOCIATED VIRUSES IN THE ICELLIS NANO BIOREACTOR
Authors: Vassilieva S. , Velyaev О. , Galkin I. , Zoticov А. , Loginov V. , Starikova А. , Skopenkova V. , Trushkin N. , Tsvircun D. , Khamatova А. , Shmidt А. , Egorova Т.
Published: November 2020

Here we present results of condition optimisation for production of recombinant adeno-associated virus using iCellis Nano bioreactor for HEK293T cells.
DEVELOPMENT OF A PHOTOSENSITIZER DELIVERY SYSTEM FOR THERAPY AND DIAGNOSTICS IN ONCOLOGY
Authors: Semkina A.Semkina , Abakumov M.Abakumov , Ostroverkhov P.Ostroverkhov , Grin M.
Published: November 2020

In this work, the MNP-HSA-PEG-PS@4 complex was obtained and its physicochemical properties were studied. Biological studies have also been conducted. Namely, the ability of the drug to accumulate in CT26 tumor cells in vitro and the kinetics of drug accumulation in the tumor in vivo were studied. Then, the effectiveness of photodynamic therapy was studied under different conditions. The maximum therapeutic effect was achieved with irradiation at 1 hour after injection of the drug.
ROLE OF NEUTROPHILS IN THE DELIVERY OF NANOPARTICLE INTO THE TUMOR
Authors: Naumenko V. , Chekhonin V.
Published: November 2020

Mechanisms of liposomes and magnetic nanoparticles accumulation in the tumor tissue were shown to be associated with neutrophils. The intravital microscopy allowed to visualize the transfer of magnetic nanoparticles by neutrophils that captured these nanoparticles, while liposomes accumulate in the tissue via micro- and macroleakages appearing at sites of neutrophil extravasation.
DECIDING ON NON-VIRAL DELIVERY SYSTEM FOR SIRNA TO MSCS
Authors: Bukharova T. , Buianova A. , Davygora K. , Goldshtein D.
Published: November 2020

siRNA transfection efficiency comparative evaluation using 5 different agents showed preferability of agents based on cationic polymers rather than liposomes for MSCs
This work was supported by the state assignment for the Federal State Budgetary Institution «Research Centre for Medical Genetics»
INTERACTION OF GOLD NANOPARTICLES WITH HUMAN HEPATOCYTES HEPG2 LINE UNDER CONDITIONS OF 2D- AND 3D-CULTIVATION
Authors: Chelobanov B. , Poletaeva J. , Tupitsyna A. , Mosyakin N. , Ryabchikova E.
Published: November 2020

A previously undescribed phenomenon of the inability of cells to uptake gold nanoparticles (GNPs) was discovered when studying HepG2 cells under the conditions of 2D- and 3D- cultivation (monolayer and spheroids). The same cells readily internalized GNPs functionalized with polyethyleneimine.
HYBRID MAGNETITE-GOLD NANOPARTICLES FOR TERANOSTICS OF ONCOLOGICAL DISEASES
Authors: Nalench Yu. , Myrovali E. , Garanina A. , Abakumov М. , Spasova M. , Angelakeris M. , Farle M. , Majouga A. , Wiedwald U. , Klyachko N.
Published: November 2020

In this work, hybrid magnetite-gold nanoparticles have been obtained, which have high contrast characteristics in magnetic resonance imaging and heat-release characteristics in magnetic particle hyperthermia, demonstrated in vitro.
MODIFICATION OF HYDROLYTIC ENZYMES FROM NORTHERN DEER PANCARRIA WITH THE PURPOSE OF DEVELOPMENT OF THE SORPTION- CHROMATOGRAPHIC METHOD FOR ISOLATION AND CLEANING
Authors: Stuchaeva A. , Glazova N.
Published: November 2020

The modification of hydrolytic enzymes was carried out in order to increase their stabilization by nanostructures based on β-cyclodextrins. The effect of various ratios of b-cyclodextrins on the activity and stability of enzymes was studied. The parameters of the sorption-chromatographic process of sorption of pancreatic in the presence of β-cyclodextrins were studied.
DETERMINATION OF THE FATTY ACID COMPOSITION OF ASTAXANTIN ESTERS AND OBTAINING NANOEMULSIONS ON THEIR BASIS
Authors: Lotosh N. , Turanova V. , Selischeva A.
Published: November 2020

Fatty acid composition of astaxanthin monoesters isolated from the microalgae extract Haematococcus pluvialis was determined by HPLC. Nanoemulsions of astaxanthin esters with phosphatidylcholine and albumin were obtained. The particle sizes in the nanoemulsions, zeta potential and the polydispersity index were determined.
DEVELOPMENT AND EVALUATION OF LOW MOLECULAR WEIGHT COMPOUNDS CONJUGATES FOR ASGPR-TARGETED DRUG DELIVERY
Authors: Petrov R. , Yamansarov E. , Binevski P. , Majouga A. , Klyachko N.
Published: November 2020

The conjugates of paclitaxel and betulin with N-acetylgalactosamine were obtained, their affinity to the asialoglycoprotein receptor was evaluated via surface plasmon resonance spectroscopy technique. Thermodynamic dissociation constants (KD) were determined. The influence of the structural elements of the linker on the binding of the receptor was studied.
DEVELOPMENT OF A CELL-BASED ASSAY METHOD FOR SCREENING AUTOANTIBODIES TO NMDA-RECEPTORS IN THE FIRST EPISODES OF SCHIZOPHRENIA AND OTHER MENTAL DISORDERS
Authors: Murashko A. , Pavlov K. , Gurina O. , Shmukle r A.
Published: November 2020

For the early detection and successful treatment of NMDA receptor encephalitis, an easy-to-use and reliable test system must be developed. In addition, it is important to isolate NMDA-receptor encephalitis from various symptomatically similar mental illnesses. A reliable criterion is the detection of antibodies to NMDA receptors in the blood serum and CSF of patients.
CYTOTOXICITY AND MICELLAR PROPERTIES OF SYMMETRIC LIPOPHILIC POLYAMINES
Authors: Shcheglova E. , Makarova D. , Puchkov P. , Shmendel E. , Maslov M.
Published: November 2020

Micelle-forming symmetric lipophilic polyamines were obtained. Minimal CMC values were defined for norspermine- based derivatives. Cytotoxicity test of symmetric lipophilic polyamines showed a increase of IC50 in comparison of unsymmetrical analogs.
REPERTOIRE OF CIRCULATING ANTIBODIES FOR DIAGNOSING MOLECULAR SUBTYPES OF BREAST CANCER
Authors: Abramova K. , Kolosova E. , Drozd V. , Gordeeva A. , Shoikhet J. , Lazarev A. , Johnston S. , Chapoval A.
Published: November 2020

In this work, the results of work on the assessment of the repertoire of circulating antibodies using a technological platform - peptide microarray. In the course of the work, peptides were identified that interact with circulating antibodies in blood plasma of patients with different molecular subtypes of breast cancer.
OPTIMIZATION OF THE TECHNOLOGY OF BINDING COMPONENT PREPARATION FOR CATIONIC LIPOSOMES IN GENE THERAPY
Authors: Egorov D. , Maslov M.
Published: November 2020

Cationic liposomes for nucleic acid delivery were prepared from dimeric polycationic amphiphile. Novel synthetic approach was developed for that. Comparison of both novel approach based on Mitsunobu reaction and previous one is provided.
ANTIBODY CONJUGATES WITH GOLD NANOPARTICLES AS A COMPONENT OF IMMUNOCHROMATOGRAPHIC DIAGNOSTICUMS: THE INFLUENCE OF SYNTHESIS CONDITIONS ON THE COMPOSITION AND REACTIVITY
Authors: Byzova N. , Zherdev A. , Dzantiev B.
Published: November 2020

A series of preparations of gold nanoparticles with diameters from 13 to 60 nm and their conjugates with antibodies (murine immunoglobulins of class G) of different composition were obtained. The composition of the conjugates and the amount of antibodies that retain their reactivity in an immobilized form are characterized. Using the example of immunochromatographic test systems for the detection of D-dimer and C-reactive protein, the effectiveness of conjugates as analytical reagents is compared.
DEVELOPMENT OF FAST HIGHLY SENSITIVE IMMUNOBLOTING METHOD WITH MAGNETIC LABELS
Authors: Kanev I. , Malakhova E. , Shlyapnikova E.
Published: November 2020

A new ultra-sensitive method of immunoblotting based on the electrophoresis between membranes from regenerated cellulose is proposed.
RECOMBINANT EXPRESSION OF NOVEL BACTERIOCIN ANALOGUES
Authors: Ovchinnikova T. , Balandin S.
Published: November 2020

In this work we investigated relationship between structural features of novel bacteriocin analogues and the spectrum of their antimicrobial activity.
COMPOUNDS HAVING THE IMMUNOSTIMULATING ACTIVITY EX VIVO, AS POSSIBLE ADJUVANTS FOR GENETICALLY ENGINEERED ANTIVIRAL VACCINES
Authors: Lesnova E. , Permyakova K. , Pronin A.
Published: November 2020

In the mouse lymphocyte culture ex vivo, the immunostimulating activity of a number of previously unexplored compounds was determined. Six of the 19 compounds showed an increase in the functional activity of T cells. These compounds are promising as adjuvants for genetically engineered vaccines.
IMMUNOGENIC AND PROTECTIVE PROPERTIES OF RECOMBINANT VACCINIA VIRUS STRAIN, EXPRESSING GENE CASSETTE OF MARBURG VIRUS STRUCTURAL PROTEINS
Authors: Semenova A. , Sivolobova G. , Grazhdantseva A. , P’yankov S. , Taranov O. , P’yankov O. , Kochneva G.
Published: November 2020

Based on the highly attenuated vaccinia virus MVA strain, a recombinant variant MVA-GP-VP40-MARV was constructed, which expresses a cassette of the GP and VP-40 genes of the Marburg virus with the formation of immunogenic virus-like particles and protects Guinea pigs from a lethal infection by the Marburg virus.
THE ABILITY OF PHENOLIC ACIDS OF PLANT ORIGIN TO PROTECT THE ORGANISM FROM INFLUENZA INFECTION
Authors: Bogoyavlenskiy А. , Alexyuk P. , Sokolova N. , Zaitseva I. , Berezin V.
Published: November 2020

It is shown that gallic acid, ellagic acid and patuletin have pronounced prophylactic properties that neutralize the development of experimental influenza infection.
DETECTION OF NEW COPIES OF SINE IN THE RICE GENOME
Authors: Kamionskaya A. , Korotkov E.
Published: November 2020

We represent here a new method for the detection of new copies of SINE elements. The method is based on the correlation of pairs of symbols. The correlation is used for the construction of a position-specific matrix as well as for the search of new repeat copies using the matrix. This allows us to enlarge the alphabet and to increase the sensitivity of the method. The method was used to study the rice genome. As a result, new copies of SINE repeats that were not included in the standard annotation were found. The number of false positives was evaluated.
DIVERSITY OF ENZYME CATALYSTS AND THEIR ACTION MECHANISMS FOR NEUTRALISATION PROCESS OF ORGANOPHOSPHORUS NEUROTOXINS
Authors: Efremenko E.
Published: November 2020

The mechanisms of action of various enzymes acting on organophosphorus compounds (OPCs) were analyzed. The knowledge generated to date creates all the necessary prerequisites for the active application of biocatalysts in various fields of biotechnology.
FORMATION OF IRON SULFIDES BY SULPHATE-REDUCING BACTERIA FROM GEOTHERMAL ECOSYSTEMS
Authors: Antsiferov D. , Lukina A. , Ikkert O.
Published: November 2020

Crystalline phases in biogenic sediments formed by Desulfotomaculum sp. DPr and Desulfovibrio sp. KZ1 from geothermal sources were studied. Marcasite (FeS2), melnikovite (FeSххH2O) and greigite (Fe3S4) were detected. Composition of the crystalline phase depends on the physicochemical conditions of the environment. The association of crystals with the cell surface, membranes and periplasmic space was revealed. Intracellular crystallization presumably involves systems responsible for the transport or cation chelation.
EXPRESS CONTROL OF ANTIBIOTIC BACITRICIN IN MILK: DEVELOPMENT AND TESTING OF AN IMMUNOCHROMATOGRAPHIC TEST SYSTEM
Authors: Serchenya T. , Vashkevich I. , Zherdev A. , Sviridov O. , Dzantiev B.
Published: November 2020

The immunochromatographic test system was developed for rapid control of polypeptide antibiotic bacitracin in milk. Its analytical parameters were determined. Visual and instrumental detection limits are 100 and 1.0 ng/ml, working range of quantitative measurements – 3–80 ng/ml, time of the assay – 10 min. The test system allows obtaining reliable information about the content of bacitracin in milk without sample preparation. The test system was validated for 90 samples of milk; good correlation with the results obtained using a commercial enzyme immunoassay kit was shown. The degree of bacitracin revealimg in milk ranged from 75 to 140%.
THE PRINCIPLE OF IDENTIFICATION OF TISSUE- AND SPECIES-SPECIFIC SUBSTANCES OF PROTEIN-PEPTIDE NATURE IN MUSCLE TISSUE OF ANIMALS
Authors: Chernukha I. , Khvostov D.
Published: November 2020

A scheme was developed for constructing proteomic maps and spectra of identified proteins and peptides of meat and meat products (using cooked sausages as an example) using bioinformation processing of data, and a software package — the atlas “Proteomic maps of meat and meat products” was formed as the main tool for confirming the unique name of the standardized Russian meat products.
INVESTIGATION OF VARIOUS WAYS TO STABILIZE LACTIC ACID BACTERIA CELLS DURING LONG-TERM STORAGE
Authors: Nikolaev Yu. , Ulanova R. , Shakir I. , Khreptugova A.
Published: November 2020

Various methods of stabilizing the cells of the lactic acid bacterium Enterococcus faecium during long-term storage were studied. It is shown that the long-term survival of E. faecium is promoted by the addition of Enterosgel, Polysorb, the use of LB substratum, as well as their immobilization in humic-silanol gel.
EFFECT OF BUCKWHEAT EXTRACTS ON VALUABLE BIOTECHNOLOGICAL PROPERTIES OF LACTOBACILLUS ACIDOPHILUS
Authors: Irkitova A. , Dudnik D.
Published: November 2020

The effect of roasted and sprouted buckwheat grains extracts on the valuable biotechnological properties of Lactobacillus acidophilus has been studied. These prebiotics stimulate the growth and increase the number of microorganisms in certain concentrations; give the acidophilic starter a soft sour-milk taste.
IMMOBILIZED ONTO HYBRID MAGNETITE-GOLD NANOPARTICLESPHENYLA CETONEMONOOXYGENESE AND ITSREGULATION UNDER LOW-FREQUENCY MAGNETIC FIELD
Authors: Golovin Yu. , Secundo F. , Klyachko N.
Published: November 2020

PAMO was immobilized onto Ni-NTA modified hybrid magnetite-gold nanoparticles through polyhistidinemotife. As a result of immobilization, enzyme has become fully inactive. Under the expose to 50 Hz 100 mT magnetic field,catalyzed by enzyme reaction rate increases 1,5 times due to PAMO desorption from nanoparticles.
POTENTIAL AND PROSPECTS OF NATURAL BIOMATERIALS: SYNTHESIS, PROPERTIES, APPLICATIONS
Authors: Kiselev E. , Shishatskaya E.
Published: November 2020

The report presents the results on destructible biocompatible biopolymers of microbiological origin - polyhydroxyalkaneotam, including synthesis, properties of the obtained polymer products and the results of biomedical research.
TAXIFOLIN POLYMERIZATION IN DEEP EUTECTIC SOLVENT USING LACCASE-MEDIATOR SYSTEM
Authors: Morozova O. , Khlupova M. , Shumakovich G. , Gromova E. , Yaropolov A. , Vasil’eva I.
Published: November 2020

An oxidative polymerization of flavonoid taxifolin (dihydroquercetin) in betaine-glycerin (B-G, 1: 2) as cosolvent medium has been performed using laccase from basidial fungus Trametes hirsuta as a biocatalyst and TEMPO as a redox mediator. The terminal oxidizing agent was atmospheric oxygen. Under optimal synthesis conditions, dihydroquercetin oligomers (oligo DHQ) with a weight average molecular weight of 1800 g / mol, a polydispersity index of 1.09 and a yield of 57 ± 7% were obtained.
CREATION OF CELL CULTURE-PRODUCER OF MODIFIED INSULIN-LIKE GROWTH FACTOR 1
Authors: Aronova Ek. , Bazarnova Yu.
Published: November 2020

A cell culture of fibroblasts (Fib) from Rattus norvegicus rats skin samples was capable of modified insulin-like growth factor 1 (IGF-LR3) gene expressing was obtained. Recombinant protein expression was shown.
ACTION OF METABOLITES PROBIOTIC STRAINS BACILLUS SUBTILIS ON THE BIOFILM FORMATION OF OPPORTUNISTIC BACTERIA
Authors: Mikhaylova N.
Published: November 2020

In the natural environment, most microorganisms exist in the form of biofilms, which provide significant advantages for their persistence in the environment. As means to overcome the biofilm formation of opportunistic bacteria, the metabolites of Bacillus subtilis probiotic strains are of interest.
NEW RECOMBINANT BONE MORPHOGENETIC PROTEIN-2 (BMP-2): OSTEOGENIC ACTIVITY IN THE COMPOSITION WITH VARIOUS MATERIALS FOR REGENERATIVE MEDICINE
Authors: Gromov A. , Karyagina A.
Published: November 2020

A new variant of recombinant prokaryotic bone morphogenetic protein-2 (rhBMP-2) is characterized by high activity in vitro and induces pronounced osteogenesis in vitro in the composition with various natural and synthetic materials.
OBTAINING OF VATERITE MICROPARTICLES WITH AN IMMOBILIZED ENZYME – CATALASE BY CO- SYNTHESIS
Authors: Balabushevich N. , Volodkin D. , Eremeev N. , Klyachko N.
Published: November 2020

Among the polymorphic modifications of CaCO3, vaterite attracts much attention due to its unique properties such as a high specific surface area, controlled particle size [1], and it is also one of the most popular carriers for the manufacture of microparticles in biotechnology and medicine [2].
INCREASING PERMEABILITY OF OUTER MEMBRANE OF E.COLI UNDER ULTRA-LOW FREQUENCY ALTERNATING MAGNETIC FIELD IN THE PRESENCE OF MAGNETIC NANOPARTICLES
Authors: Nikitin A. , Dagaev N. , Gribanovsky S. , Ghigachev A. , Golovin D. , Legotsky S. , Veselov M. , Vlasova K. , Lapankova A. , Miroshnikov K. , Belogurova N. , Zaitseva E. , Kabanov A. , Majouga A. , Golovin Yu. , Klyachko N.
Published: November 2020

Currently, the bacterial etiology infectious diseases still remain a global health problem. Most of them are caused by gram-negative pathogenic microorganisms. The traditional method of infectious diseases treatment is based on the use of antibiotics. However, the rapid development of the resistance of pathogenic microorganisms to existing antibiotics forces to seek alternatives to traditional therapy. One of such alternatives is the therapy with bacteriophage endolysins - bacteriolytic enzymes capable of destroying the bacterial cell wall by hydrolyzing the peptidoglycan. Endolysins are highly specific for certain pathogens. The main limitation of their use towards gram- negative bacteria is the presence of an outer membrane in the latter preventing the penetration of lytic enzyme to its substrate. The effectiveness of endolysin penetration can be increased by destabilizing the outer membrane of gram-negative bacteria
A Review on Voice-based Interface for Human-Robot Interaction
Authors: Badr Ameer , Abdul-Hassan Alia
Published: November 2020

With the recent developments of technology and the advances in artificial intelligence and machine learning techniques, it has become possible for the robot to understand and respond to voice as part of Human-Robot Interaction (HRI). The voice-based interface robot can recognize the speech information from humans so that it will be able to interact more naturally with its human counterpart in different environments. In this work, a review of the voice-based interface for HRI systems has been presented. The review focuses on voice-based perception in HRI systems from three facets, which are: feature extraction, dimensionality reduction, and semantic understanding. For feature extraction, numerous types of features have been reviewed in various domains, such as time, frequency, cepstral (i.e. implementing the inverse Fourier transform for the signal spectrum logarithm), and deep domains. For dimensionality reduction, subspace learning can be used to eliminate the redundancies of high-dimensional features by further processing extracted features to reflect their semantic information better. For semantic understanding, the aim is to infer from the extracted features the objects or human behaviors. Numerous types of semantic understanding have been reviewed, such as speech recognition, speaker recognition, speaker gender detection, speaker gender and age estimation, and speaker localization. Finally, some of the existing voice-based interface issues and recommendations for future works have been outlined.
COVID 19 AND DISINFODEMIC : A NEW AGE PROBLEM
Authors: Younis Muhammad
Published: November 2020

As the numbers of patients infected with COVID 19 keep increasing, we are faced with yet another challenge the likes of which haven't been seen before. With the bombardment of too much information reaching the general population, we are faced with a new dilemma as individuals and physicians to recognize the truth form the false.
Re: COVID 19 - once in a century pathogen
Authors: Fatima Aleeza
Published: November 2020

N/A
Global Temporal and Geographic Stability of Brines on Present-day Mars
Authors: Chevrier Vincent F. , Rivera-Valentín Edgard G. , Soto Alejandro , Altheide Travis S.
Published: November 2020

We combine experimentally verified constraints on brine thermodynamics along with a global circulation model to develop a new extensive framework of brine stability on the surface and subsurface of Mars. Our work considers all major phase changes (i.e., evaporation, freezing, and boiling) and is consistent, regardless of brine composition, so it is applicable to any brine relevant to Mars. We find that equatorial regions typically have temperatures too high for stable brines, while high latitudes are susceptible to permanent freezing. In the subsurface, this trend is reversed, and equatorial regions are more favorable to brine stability, but only for the lowest water activities (and lowest eutectic temperatures). At locations where brines may be stable, we find that their lifetimes can be characterized by two regimes. Above a water activity of ∼0.6, brine duration is dominated by evaporation, lasting at most a few minutes per sol. Below a water activity of 0.6, brine duration is bound by freezing or boiling; such brines are potentially stable for up to several consecutive hours per sol. Our work suggests that brines should not be expected near or on the Martian surface, except for low eutectic water activity salts such as calcium or magnesium perchlorate or chlorate, and their (meta)stability on the surface would require contact with atmospheric water vapor or local ice deposits.
Ún freno a la conqista: La resistencia de los cacicazgos indígenas americanos en la bibliografía histórico-antropológica
Authors: Lázaro Avila Carlos
Published: November 2020

Este artículo analiza la bibliografía histórico-antropológica existente acerca del fenómeno de la conquista en los territorios ocupados por las sociedades de cacicazgos americanas, teniendo en cuenta la hipótesis de que en esas sociedades se produjo una dinámica interna a raíz de la violenta presencia hispana.
El papel de la Iglesia de Centroamérica en la guerra contra W. Walker (1856-1860)
Authors: Sagastume Fajardo Alejandro S.
Published: November 2020

La invasión y política de Walker en Nicaragua contó con un apoyo inicial del obispo Herdocia (1856), aunque recibió protestas y campañas de todos los obispos del área, por sus criterios de libertad religiosa e intentos anexionistas. Se siguen los informes de los diplomáticos españoles desde sus puestos centroamericanos, del Archivo del Ministerio de Asuntos Exteriores (Madrid).
Formación, crisis y transformación de la estructura agraria de Cochabamba El caso de la hacienda de Paucarpata y de la comunidad del Passo, 1538-1645 y 1872-1929
Authors: Jackson Robert H. , Gordillo Claure José
Published: November 2020

Para el estudio sobre la formación de la hacienda y su relación con la comunidad, así como sobre la transformación de las estructuras económicas de Cochabamba durante cuatro siglos, se han realizado análisis de algunas zonas que constituyeron el núcleo agrícola fundamental del Valle Bajo, la hacienda de Paucarpata y el ayuntamiento del Passo. Este análisis microhistórico permite conocer la evolución de diferentes aspectos de la economía rural: migración, mano de obra, estructura demográfica, composición de las tierras, etc.
Partidos políticos y golpe de estado en Bolivia. La política nacional-popular de Bautista Saavedra, 1921-1925
Authors: Irurozqui Victoriano Marta
Published: November 2020

La estrategia liberal (1899-1920) de involucrar a los sectores subalternos en la definición de la hegemonía en el interior de la élite tuvo una nueva manifestación en el régimen de Bautista Saavedra (1921-25). La lucha por el poder y el comportamiento de las clientelas políticas enfrentó el estado con las élites políticas, desembocando en un golpe de estado para lograr un sistema político favorable al proyecto de reconversión.
Consequence and Consequences in Jane Austen
Authors: Lecercle Jean-Jacques
Published: November 2020

This reading of Pride and Prejudice and Mansfield Park suggests that the semantic framework of the novels is provided by the contrast between two meanings of the word consequence, the archaic meaning of social or emotional importance and the common and garden meaning of effect of a cause. It also suggests that the narrative structure of the novels is that of a game of consequences, a game that was played at the time of Jane Austen.
Play and Games in Fiction and Theory
Authors: Goggin Joyce
Published: November 2020

This article provides an historical overview of various theories of play, games and literature, and examines a number of examples taken from a wide range of texts both theoretical and literary. In doing so, the author analyses specific texts that address the role of play up to the present, and discusses the ludic in relation to mimesis, textuality and literature. The author also discusses fictional narratives on digital platforms such as video games, as well as some of the consequences or ramifications of what is known as the “gamification” the world we currently inhabit.
The Agonistics of Reading: Playing, Gambling, Committing
Authors: Hercend Olivier
Published: November 2020

From Michel Picard’s La lecture comme jeu to Umberto Eco’s model of the “game of chess”, reading has often been compared to a kind of game. Games serve as a useful template of interaction, highlighting both the exterior set of rules governing an activity, and the agency that these rules leave to the individual. Yet games are also a constitutive human activity, with myriads of variants, from the free play of children to the gambler’s thrill to the highly ritualized sets of actions and reactions seen in martial arts or chess. This article proposes to review classical and contemporary theories of reading based on their specific use of the metaphor of reading as a game. It first presents the structuralist and phenomenological approaches, which tend to define reading as a performance based on pre-established rules, like a game of chess. It then delves into theories that instead choose to highlight the incalculable aspect of every new reading, the possibility for the reader to go off the beaten path. These tend to see reading more as a game of chance than a game of chess. This does not mean, however, that they construe reading as licentious: gambles involve stakes. Theories like Jean-Jacques Lecercle’s Marxist pragmatics are most specific in explaining what the reader is actually committing to. The stance we take, our interaction with texts as “interpellations”, are part and parcel of our lives as social and political beings. They are the products of a certain context, but they may in turn influence or call into question the very structures that make them possible. This is why this article suggests reading be examined through the notion of agonistics. Taking up the ancient Greek word “agôn”, which implies that games are forms of trial made to reveal something of the player’s nature, the agonistics of reading posits that reading must not be seen as an isolated phenomenon. On the contrary, the challenge that texts pose, to confront them or to accept them, is fundamental in the construction of our identity as readers and as human beings. This dialectics of self-revelation and self-construction, through the interaction with texts, is the often unspoken yet decisive game that every reader plays.