bluuebunny/crossref_metadata_2025 huggingface dataset:
Circulating microRNAs as Potential Novel Diagnostic Biomarkers to Predict Drug Resistance in Temporal Lobe Epilepsy: A Pilot Study
Authors: De Benedittis Selene , Fortunato Francesco , Cava Claudia , Gallivanone Francesca , Iaccino Enrico , Caligiuri Maria Eugenia , Castiglioni Isabella , Bertoli Gloria , Manna Ida , Labate Angelo , Gambardella Antonio
Published: January 2021

MicroRNAs (miRNAs) are small noncoding RNAs that have emerged as new potential epigenetic biomarkers. Here, we evaluate the efficacy of six circulating miRNA previously described in the literature as biomarkers for the diagnosis of temporal lobe epilepsy (TLE) and/or as predictive biomarkers to antiepileptic drug response. We measured the differences in serum miRNA levels by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) assays in a cohort of 27 patients (14 women and 13 men; mean ± SD age: 43.65 ± 17.07) with TLE compared to 20 healthy controls (HC) matched for sex, age and ethnicity (11 women and 9 men; mean ± SD age: 47.5 ± 9.1). Additionally, patients were classified according to whether they had drug-responsive (n = 17) or drug-resistant (n = 10) TLE. We have investigated any correlations between miRNAs and several electroclinical parameters. Three miRNAs (miR-142, miR-146a, miR-223) were significantly upregulated in patients (expressed as average expression ± SD). In detail, miR-142 expression was 0.40 ± 0.29 vs. 0.16 ± 0.10 in TLE patients compared to HC (t-test, p < 0.01), miR-146a expression was 0.15 ± 0.11 vs. 0.07 ± 0.04 (t-test, p < 0.05), and miR-223 expression was 6.21 ± 3.65 vs. 1.23 ± 0.84 (t-test, p < 0.001). Moreover, results obtained from a logistic regression model showed the good performance of miR-142 and miR-223 in distinguishing drug-sensitive vs. drug-resistant TLE. The results of this pilot study give evidence that miRNAs are suitable targets in TLE and offer the rationale for further confirmation studies in larger epilepsy cohorts.
Robot Evacuation on a Line Assisted by a Bike
Authors: Jawhar Khaled , Kranakis Evangelos
Published: January 2021

Two robots and a bike are initially placed at the origin of an infinite line. The robots are modelled as autonomous mobile agents whose communication capabilities are either in the wireless or face-to-face model, while the bike neither can move nor communicate on its own. Thus, the bike is not autonomous but rather requires one of the robots to ride it. An exit is placed on the line at distance d from the origin; the distance and direction of the exit from the origin is unknown to the robots. Only one robot may ride the bike at a time and the goal is to evacuate from the exit in the minimum time possible as measured by the time it takes the last robot to exit. The robots can maintain a constant walking speed of 1, but when riding the bike they can maintain a constant speed v>1 (same for both robots). We develop algorithms for the evacuation of the two robots from the unknown exit and analyze the evacuation time defined as the time it takes the second robot to evacuate. In the wireless model we present three algorithms: in the first the robots move in opposite direction with max speed, in the second with a specially selected “optimal” speed, and in the third the robot imitates the biker (i.e., robot riding the bike). We also give three algorithms in the Face-to-Face model: in the first algorithm the robot pursues the biker, in the second the robot and the biker use zig-zag algorithms with specially chosen expansion factors, and the third algorithm establishes a sequence of specially constructed meeting points near the exit. In either case, the optimality of these algorithms depends on v>1. We also discuss lower bounds.
Predicting the Generalization Ability of a Few-Shot Classifier
Authors: Bontonou Myriam , Béthune Louis , Gripon Vincent
Published: January 2021

In the context of few-shot learning, one cannot measure the generalization ability of a trained classifier using validation sets, due to the small number of labeled samples. In this paper, we are interested in finding alternatives to answer the question: is my classifier generalizing well to new data? We investigate the case of transfer-based few-shot learning solutions, and consider three settings: (i) supervised where we only have access to a few labeled samples, (ii) semi-supervised where we have access to both a few labeled samples and a set of unlabeled samples and (iii) unsupervised where we only have access to unlabeled samples. For each setting, we propose reasonable measures that we empirically demonstrate to be correlated with the generalization ability of the considered classifiers. We also show that these simple measures can predict the generalization ability up to a certain confidence. We conduct our experiments on standard few-shot vision datasets.
Luminescence Response and Quenching Models for Heavy Ions of 0.5 keV to 1 GeV/n in Liquid Argon and Xenon
Authors: Hitachi Akira
Published: January 2021

Biexcitonic collision kinetics with prescribed diffusion in the ion track core have been applied for scintillation response due to heavy ions in liquid argon. The quenching factors q = EL/E, where E is the ion energy and EL is the energy expended for luminescence, for 33.5 MeV/n 18O and 31.9 MeV/n 36Ar ions in liquid Ar at zero field are found to be 0.73 and 0.46, compared with measured values of 0.59 and 0.46, respectively. The quenching model is also applied for 80–200 keV Pb recoils in α-decay, background candidates in direct dark matter searches, in liquid argon. Values obtained are ~0.09. A particular feature of Birks’ law has been found and exploited in evaluating the electronic quenching factor qel in liquid Xe. The total quenching factors qT for 0.5–20 keV Xe recoils needed for weakly interacting massive particle (WIMP) searches are estimated to be ~0.12–0.14, and those for Pb recoils of 103 and 169 keV are 0.08 and 0.09, respectively. In the calculation, the nuclear quenching factor qnc = Eη/E, where Eη is the energy available for the electronic excitation, is obtained by Lindhard theory and a semi-empirical theory by Ling and Knipp. The electronic linear energy transfer plays a key role.
Conveyor-Belt Dryers with Tangential Flow for Food Drying: Development of Drying ODEs Useful to Design and Process Adjustment
Authors: Friso Dario
Published: January 2021

The mathematical investigation presented in this paper concerns the conveyor-belt dryer with tangential flow operating in co-current. This dryer is bigger than the continuous through-circulation conveyor dryer but has the advantage of better preserving the organoleptic and nutritional qualities of the dried product. In a previous work a mathematical modeling of the conveyor-belt dryer with tangential flow was carried out to offer guidelines for its optimized design. The last of those design guidelines indicated the need for an optimized adjustment of the dryer to ensure the constant maintenance of the final moisture content of the product. The fast and very precise measurement of the moisture content as the first step in the feedback chain was therefore necessary. Considering the difficulty of this type of measurement, two specific ordinary differential equations (ODEs) were obtained with the mathematical investigation of this work. Their solution became a relationship between the final moisture content of the product, the outlet air temperature, and other quantities that could be easily implemented in an automatic dryer control system. Therefore, the fast and accurate and much less expensive measurement of the temperature of the air leaving the dryer, owing to the relationship found, replaces the measurement of moisture content for the adjustment system. The experimental verification of the relationship highlighted the need to introduce a modification by which the relationship was finally validated.
Considerations in the Use of Gravitational Valves in the Management of Hydrocephalus. Some Lessons Learned with the Dual-Switch Valve
Authors: Poca Maria A. , Gándara Dario F. , Rosas Katiuska , Alcina Aloma , López-Bermeo Diego , Sahuquillo Juan
Published: January 2021

In the past decade, there has been a clear trend towards better outcomes in patients with hydrocephalus, especially those with normal pressure hydrocephalus (NPH). This is partly due to the availability of more sophisticated hardware and a better understanding of implants. However, there is little evidence to show the superiority of a specific type of valve over another. The most commonly reported consequence of hydrodynamic mismatch is shunt over-drainage. Simple differential pressure valves, with a fixed opening pressure or even adjustable valves, lead to non-physiologic intraventricular pressure (IVP) as soon as the patient moves into an upright posture. These valves fail to maintain IVP within physiological limits due to the changes in hydrostatic pressure in the drainage system. To solve this problem more complex third-generation hydrostatic valves have been designed. These gravitational devices aim to reduce flow through a shunt system when the patient is upright but there are important technical differences between them. Here we review the main characteristics of the Miethke® Dual-Switch valve, which includes two valve chambers arranged in parallel: a low-opening pressure valve, designed for working in the supine position, and a second high-opening pressure valve, which starts working when the patient assumes the upright position. This paper specifies the main advantages and drawbacks of this device and provide a series of recommendations for its use. The discussion of this specific gravitational valve allows us to emphasize the importance of using gravitational control in implanted shunts and some the caveats neurosurgeons should take into consideration when using gravitational devices in patients with hydrocephalus. The correct function of any gravitational device depends on adequate device implantation along the vertical body axis. Misalignment from the vertical axis equal to or more than 45° might eliminate the beneficial effect of these devices.
Prevalence of Chronic Inducible Urticaria in Elderly Patients
Authors: Napolitano Maddalena , Fabbrocini Gabriella , Stingeni Luca , Patruno Cataldo
Published: January 2021

Background: No data currently exist regarding the epidemiology of chronic inducible urticarias (CIndUs) in the ≥65-year-old population. Objective: The study aimed to determine the prevalence of CIndUs among elderly patients affected by chronic urticaria (CU). Methods: The medical records of all patients referred to us with a diagnosis of CU from January 2008 to September 2020 were retrospectively reviewed, and the patients with CIndUs were identified. The subjects aged 65 years or above were included in the study. Results: The number of patients aged 65 years or above was 153 out of 1970 subjects affected by CU (7.77%; 92 females (60.13%); mean age 70.96 ± 4.22). Out of 153, 26 patients (16.99%; 20 females (76.9%); mean age 71.23 ± 2.6 years) were diagnosed with CIndUs. Most subjects (25/26; 96.15%) suffered from physical urticarias. Symptomatic dermographism was the most frequent, affecting 65.38% (17/26) of our patients, followed by cold urticaria (6/26 (23.08%) cases). Conclusion: Our data seem to indicate that CIndUs may also affect the elderly, although it occurs less frequently in aging patients than in lower age groups.
Topical TRPM8 Agonist for Relieving Neuropathic Ocular Pain in Patients with Dry Eye: A Pilot Study
Authors: Yoon Hyeon Jeong , Kim Jonghwa , Yang Jee Myung , Wei Edward T. , Kim Seong Jin , Yoon Kyung Chul
Published: January 2021

Background: Activation of TRPM8, a cold-sensing receptor located on the cornea and eyelid, has the potential to relieve the neuropathic ocular pain (NOP) in dry eye (DE) by inhibiting other aberrant nociceptive inputs. We aimed to investigate the effect of a topical TRPM8 agonist, cryosim-3 (C3), on relieving DE-associated NOP. Methods: We conducted a prospective pilot study of 15 patients with DE-associated NOP. These patients applied topical C3 to their eyelid, 4 times/day for 1 month. The patients underwent clinical examinations. They also completed the Ocular Pain Assessment Survey (OPAS), which is a validated questionnaire for NOP, at baseline, 1 week, and 1 month after treatment. Result: At 1 week, the OPAS scores of eye pain intensity, quality of life (driving/watching TV, general activity, sleep, and enjoying life/relations with other people), and associated factors (burning sensation, light sensitivity, and tearing) improved. The total OPAS scores of eye pain intensity, quality of life, and associated factors remained improved at 1 month. The Schirmer test scores also improved at 1 month. Conclusion: TRPM8 agonist (C3) could be a novel agent for treating patients with DE-associated NOP who are unresponsive to conventional treatments.
Characteristics of Patients Managed without Positive Pressure Ventilation While on Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome
Authors: Levin Nicholas M , Ciullo Anna L , Overton Sean , Mitchell Nathan , Skidmore Chloe R , Tonna Joseph E
Published: January 2021

Background: Extracorporeal membrane oxygenation (ECMO) has expanding indications for cardiopulmonary resuscitation including severe acute respiratory distress syndrome (ARDS). Despite the adjunct of ECMO for patients with severe ARDS, they often have prolonged mechanical ventilation and are subject to many of its inherent complications. Here, we describe patients who were cannulated for venovenous (VV) ECMO and were taken off positive pressure ventilation. Methods: This is a primary analysis of patients admitted at a tertiary medical center between the dates of August 2014 to January 2020 who were cannulated to ECMO for refractory respiratory failure. We included all patients ≥18 years old. Patients who were extubated or had a tracheostomy and taken off positive pressure while on ECMO were classified as “off positive pressure ventilation (PPV)” and were compared to patients who remained “on PPV” while on ECMO. Primary outcome was survival to hospital discharge. Secondary outcomes were ventilator free days at 30 days and 60 days after ECMO cannulation, time from cannulation to date of first out-of-bed (OOB), and hospital length of stay (LOS). Patient characteristics were derived from routine clinical information in the electronic health record (EHR). Categorical characteristics were compared using chi-square test or Fisher exact test. Continuous characteristics were compared using independent samples t-test or Wilcoxon–Mann–Whitney test. p-values were reported from all analysis. Results: Sixty-five patients were included in this retrospective analysis. Forty-eight were managed on ECMO with PPV and 17 patients were removed from PPV. Patients removed from PPV had significantly higher lung injury scores prior to cannulation (2.5 ± 0.6 vs. 1.04 ± 0.3; p = 0.031) and non-significantly longer duration of ventilation prior to ECMO (6.1 days ± 2.1 vs. 5.0 days ± 01.1; p = 0.634). One hundred percent (100%) of patients removed from PPV survived to hospital discharge compared to 45% who received PPV throughout their duration of ECMO management (p < 0.001). The mean ventilator free days at day 60 was 15 with PPV and 36 without PPV (p = 0.003). The average duration from cannulation to mobilization (i.e., out-of-bed) was 18 days with PPV and 7 days without PPV (p = 0.015). Conclusions: Patients taken off PPV while on ECMO had a very high likelihood of survival to discharge and were mobilized in half as many days. While this likely reflects patient selection, the benefit of early mobilization is well documented and the approach of extubating while on ECMO warrants further investigation.
Correlation between PlateletWorks® and PFA-100® for Measuring Platelet Function before Urgent Surgery in Patients with Chronic Antiplatelet Therapy
Authors: Anaya Rafael , Rodriguez Mireia , Gil José María , Vilalta Noelia , Merchan-Galvis Angela , Moral Victoria , Mateo José , Martinez-Zapata María José
Published: January 2021

Hemostasis is crucial for reducing bleeding during surgical procedures. The points-of-care based on the platelet function test could be useful to minimize the complications related to chronic antiplatelet therapy during surgery. The present study is aimed at comparing two point-of-care platelet function devices—Platelet Function Analyzer PFA-100® (Siemens Canada, Mississauga, ON, Canada) and Plateletworks®(Helena Laboratories, Beaumont, TX, USA). Our objective is to evaluate if they provide comparable and useful information to manage anti-aggregate patients before surgery. We included patients with a femoral fracture receiving chronic antiplatelet therapy and a median age of 89 years (range from 70 to 98). A platelet function evaluation was performed on all patients before surgery using both devices—Plateletworks® and PFA-100®. The correlation between Plateletworks® and PFA-100® was performed using Cohen’s Kappa coefficient. Twenty consecutive patients participated in the trial; 16 patients were under treatment with 75 mg/day of clopidogrel, three with >300 mg/day of acetylsalicylic acid (ASA), and only one was in treatment with both antiplatelet agents. Cohen’s Kappa coefficient was 0.327 comparing PFA-100®-ADP (adenosine diphosphate) and Plateletworks® and, 0.200 comparing PFA-100®-EPI (epinephrine) and Plateletworks®. In conclusion, we found a weak concordance comparing PFA-100® and Plateletworks®. This could partially be due to the advanced age of the included patients. However, given the limited sample size, more studies are necessary to confirm these results.
Clinical Challenges in the Management of Neuroendocrine Tumors
Authors: Panzuto Francesco
Published: January 2021

Neuroendocrine tumors (NET) are rare and heterogeneous diseases, whose prognosis is affected by several factors including the primary tumor site, grading, somatostatin receptor expression, and disease staging [...]
3D-Analysis of the Proximal Humeral Anatomy before and after Stemless Shoulder Arthroplasty—A Prospective Case Series Study
Authors: Koch Matthias , Frankewycz Borys , Voss Andreas , Kaeaeb Max , Herrmann Sebastian , Alt Volker , Greiner Stefan
Published: January 2021

Background: Stemless shoulder arthroplasty (SSA) is used to anatomically reconstruct proximal humerus geometry and preserve proximal humerus bone stock. The current literature lacks 3D-analysis of pre- and postoperative proximal humeral anatomy after SSA. The aim of this study was to prospectively analyze the humeral head anatomy using a computer-assisted topography mapping technique after SSA in relation to the preoperative status and the contralateral (not affected) side. Methods: Twenty-nine patients (mean age: 63.5 ± 11.7 years) affected by primary shoulder osteoarthritis and treated with SSA were included. Preoperative and postoperative CT scans of the affected and contralateral sites were analyzed regarding joint geometry. Clinical outcome was assessed by Constant and Disabilities of the Arm, Shoulder and Hand (DASH) score shortly before and one year after surgery. Results: Clinical outcome improved significantly. No correlation between clinical outcome and the evaluated anatomical parameters was found. There was a significant decrease of the humeral head height (p < 0.01) and radius (p = 0.03) in the preoperative versus the postoperative joint geometry. The comparison to the contralateral site showed also a significant decrease of the humeral head height (p < 0.01). All other parameters showed no significant differences. Conclusion: Proximal humeral anatomy can be almost anatomically reconstructed by SSA. Solely the humeral head height differs significantly to the preoperative as well as contralateral morphology.
Uterine Fundus Remodeling after Hysteroscopic Metroplasty: A Prospective Pilot Study
Authors: Casadio Paolo , Magnarelli Giulia , La Rosa Mariangela , Alletto Andrea , Arena Alessandro , Fontana Enrico , Morra Ciro , Talamo Maria Rita , Fabbri Matilde , Giovannico Kevin , Virgilio Agnese , Raimondo Diego , Guasina Francesca , Paradisi Roberto , Seracchioli Renato
Published: January 2021

The septate uterus is the most common congenital uterine malformation and is treated by hysteroscopic metroplasty. There are few studies on the fundal uterine changes that occur after surgery. We designed a pilot prospective observational study to evaluate by three-dimensional transvaginal ultrasound (3D-TVS) the changes not only of the internal fundal uterine profile, but also of the external one, after hysteroscopic metroplasty. Sixty women who underwent hysteroscopic metroplasty for partial or complete uterine septum (U2a and U2b subclasses of ESHRE/ESGE classification) were enrolled. We performed 3D-TVS after surgery confirming optimal removal of the septum. However, at ultrasound follow-up after three months, we observed a significant increase (p < 0.001) in the residual septum (Zr) (3.7 mm (95% CI: 3.1–4.4)), the myometrial wall thickness (Y) (2.5 mm (95% CI: 2.0–3.0)) and the total fundal wall thickness (Y + Zr) (6.2 mm (95% CI: 5.5–6.9)). Forty-three patients (72%) required a second step of hysteroscopic metroplasty. Moreover, the shape of uterine fundus changed in 58% of cases. We actually observed a remodeling of the uterine fundus with modifications of its external and internal profiles. Therefore, we propose to always perform a second ultrasound look at least three months after the metroplasty to identify cases that require a second- step metroplasty.
The Current State of Knowledge on the Clinical and Methodological Aspects of Extracorporeal Shock Waves Therapy in the Management of Post-Stroke Spasticity—Overview of 20 Years of Experiences
Authors: Opara Józef , Taradaj Jakub , Walewicz Karolina , Rosińczuk Joanna , Dymarek Robert
Published: January 2021

In many patients after stroke, spasticity develops over time, resulting in a decrease in the patient’s independence, pain, worsening mood, and, consequently, lower quality of life. In the last ten years, a rich arsenal of physical agents to reduce muscle tone such as extracorporeal shock therapy (ESWT) wave has come through. The aim of this narrative review article is to present the current state of knowledge on the use of ESWT as a supplement to the comprehensive rehabilitation of people after stroke suffering from spasticity. The PubMed and PEDro databases were searched for papers published in English from January 2000 to December 2020, 22 of which met inclusion criteria for clinical studies related to post-stroke spasticity management with ESWT. A total of 22 studies including 468 post-stroke patients—11 reports with the upper limb (267 patients) and 10 reports within the lower limb (201 patients), as well as one report including both upper and lower limb. We focused our attention on clinical and methodological aspects. Therefore, we performed the assessment of enrolled studies in terms of methodological quality using the PEDro and level of evidence using the National Institute for Health and Clinical Excellence (NICE) guidelines. Furthermore, we indicated implications for clinical practice in using ESWT for post-stroke spasticity management. Moreover, we discussed a suggestion for future research directions. In conclusion, an ESWT effectively reduces muscle tone in people with spastic limb after stroke. Further, ESWT is safe and free of undesirable side effects. The mechanism of action of ESWT on muscles affected by spasticity is still unknown. To date, no standard parameters of ESWT in post-stroke spasticity regarding intensity, frequency, location, and the number of sessions has been established. Further research, meeting the highest standards, is needed to establish uniform muscle stimulation parameters using ESWT.
The Monitoring Efficacy of Neurogenic Bowel Dysfunction Treatment on Response (MENTOR) in a Non-Hospital Setting
Authors: Studsgaard Slot Sofie Dagmar , Baunwall Simon Mark Dahl , Emmanuel Anton , Christensen Peter , Krogh Klaus
Published: January 2021

Background: Most patients with a spinal cord injury (SCI) suffer from neurogenic bowel dysfunction (NBD). In spite of well-established treatment algorithms, NBD is often insufficiently managed. The Monitoring Efficacy of Neurogenic bowel dysfunction Treatment On Response (MENTOR) has been validated in a hospital setting as a tool to support clinical decision making in individual patients. The objective of the present study was to describe clinical decisions recommended by the MENTOR (either “monitor”, “discuss” or “act”) and the use of the tool to monitor NBD in a non-hospital setting. Methods: A questionnaire describing background data, the MENTOR, ability to work and participation in various social activities was sent by mail to all members of The Danish Paraplegic Association. Results: Among 1316 members, 716 (54%) responded, 429 men (61%) and 278 women (39%), aged 18 to 92 (median 61) years. Based on MENTOR, the recommended clinical decision is to monitor treatment of NBD in 281 (44%), discuss change in treatment in 175 (27%) and act/change treatment in 181 (28%). A recommendation to discuss or change treatment was associated with increasing age of the respondent (p = 0.016) and with impaired ability to work or participate in social activities (p < 0.0001). Conclusion: A surprisingly high proportion of persons with SCI have an unmet need for improved bowel care. The MENTOR holds promise as a tool for evaluation of treatment of NBD in a non-hospital setting.
Prediction of Jacking Force in Vertical Tunneling Projects Based on Neuro-Genetic Models
Authors: Wei Xin-Jiang , Wang Xiao , Wei Gang , Zhu Cheng-Wei , Shi Yu
Published: January 2021

The vertical tunneling method is an emerging technique to build sewage inlets or outlets in constructed horizontal tunnels. The jacking force used to drive the standpipes upward is an essential factor during the construction process. This study aims to predict the jacking forces during the vertical tunneling construction process through two intelligence systems, namely, artificial neural networks (ANNs) and hybrid genetic algorithm optimized ANNs (GA-ANNs). In this paper, the Beihai hydraulic tunnel constructed by the vertical tunneling method in China is introduced, and the direct shear tests have been conducted. A database composed of 546 datasets with ten inputs and one output was prepared. The effective parameters are classified into three categories, including tunnel geometry factors, the geological factor, and jacking operation factors. These factors are considered as input parameters. The tunnel geometry factors include the jacking distance, the thickness of overlaying soil, and the height of overlaying water; the geological factor refers to the geological conditions; and the jacking operation factors consist of the dead weight of standpipes, effective overburden soil pressure, effective lateral soil pressure, average jacking speed, construction hours, and soil weakening measure. The output parameter, on the other hand, refers to the jacking force. Performance indices, including the coefficient of determination (R2), root mean square error (RMSE), and the absolute value of relative error (RE), are computed to compare the performance of the ANN models and the GA-ANN models. Comparison results show that the GA-ANN models perform better than the ANN model, especially on the RMSE values. Finally, parametric sensitivity analysis between the input parameters and output parameter is conducted, reaching the result that the height of overlaying water, the average jacking speed, and the geological condition are the most effective input parameters on the jacking force in this study.
Coastal Sensitivity/Vulnerability Characterization and Adaptation Strategies: A Review
Authors: Anfuso Giorgio , Postacchini Matteo , Di Luccio Diana , Benassai Guido
Published: January 2021

Coastal area constitutes a vulnerable environment and requires special attention to preserve ecosystems and human activities therein. To this aim, many studies have been devoted both in past and recent years to analyzing the main factors affecting coastal vulnerability and susceptibility. Among the most used approaches, the Coastal Vulnerability Index (CVI) accounts for all relevant variables that characterize the coastal environment dealing with: (i) forcing actions (waves, tidal range, sea-level rise, etc.), (ii) morphological characteristics (geomorphology, foreshore slope, dune features, etc.), (iii) socio-economic, ecological and cultural aspects (tourism activities, natural habitats, etc.). Each variable is evaluated at each portion of the investigated coast, and associated with a vulnerability level which usually ranges from 1 (very low vulnerability), to 5 (very high vulnerability). Following a susceptibility/vulnerability analysis of a coastal stretch, specific strategies must be chosen and implemented to favor coastal resilience and adaptation, spanning from hard solutions (e.g., groins, breakwaters, etc.) to soft solutions (e.g., beach and dune nourishment projects), to the relocation option and the establishment of accommodation strategies (e.g., emergency preparedness).
Colletotrichum Species Causing Anthracnose of Citrus in Australia
Authors: Wang Weixia , de Silva Dilani D. , Moslemi Azin , Edwards Jacqueline , Ades Peter K. , Crous Pedro W. , Taylor Paul W. J.
Published: January 2021

Colletotrichum spp. are important pathogens of citrus that cause dieback of branches and postharvest disease. Globally, several species of Colletotrichum have been identified as causing anthracnose of citrus. One hundred and sixty-eight Colletotrichum isolates were collected from anthracnose symptoms on citrus stems, leaves, and fruit from Victoria, New South Wales, and Queensland, and from State herbaria in Australia. Colletotrichum australianum sp. nov., C. fructicola, C. gloeosporioides, C. karstii, C. siamense, and C. theobromicola were identified using multi-gene phylogenetic analyses based on seven genomic loci (ITS, gapdh, act, tub2, ApMat, gs, and chs-1) in the gloeosporioides complex and five genomic loci (ITS, tub2, act, chs-1, and his3) in the boninense complex, as well as morphological characters. Several isolates pathogenic to chili (Capsicum annuum), previously identified as C. queenslandicum, formed a clade with the citrus isolates described here as C. australianum sp. nov. The spore shape and culture characteristics of the chili and citrus isolates of C. australianum were similar and differed from those of C. queenslandicum. This is the first report of C. theobromicola isolated from citrus and the first detection of C. karstii and C. siamense associated with citrus anthracnose in Australia.
Market Graph Clustering via QUBO and Digital Annealing
Authors: Hong Seo Woo , Miasnikof Pierre , Kwon Roy , Lawryshyn Yuri
Published: January 2021

We present a novel technique for cardinality-constrained index-tracking, a common task in the financial industry. Our approach is based on market graph models. We model our reference indices as market graphs and express the index-tracking problem as a quadratic K-medoids clustering problem. We take advantage of a purpose-built hardware architecture to circumvent the NP-hard nature of the problem and solve our formulation efficiently. The main contributions of this article are bridging three separate areas of the literature, market graph models, K-medoid clustering and quadratic binary optimization modeling, to formulate the index-tracking problem as a binary quadratic K-medoid graph-clustering problem. Our initial results show we accurately replicate the returns of various market indices, using only a small subset of their constituent assets. Moreover, our binary quadratic formulation allows us to take advantage of recent hardware advances to overcome the NP-hard nature of the problem and obtain solutions faster than with traditional architectures and solvers.
Erratum: Zhou, S., et al. Warming Effort and Energy Budget Difference of Various Human Land Use Intensity: Case Study of Beijing, China. Land 2020, 9, 280
Authors: Zhou Shenghui , Wang Ke , Yang Shiqi , Li Wenli , Zhang Yuxuan , Zhang Bin , Fu Yiming , Liu Xiaoyan , Run Yadi , Chubwa Oliva Gabriel , Zhao Guosong , Dong Jinwei , Cui Yaoping
Published: January 2021

The authors would like to change the authors’ affiliation in the recent published paper [...]
Soil-Quality Assessment during the Dry Season in the Mun River Basin Thailand
Authors: Wu Chunsheng , Dai Erfu , Zhao Zhonghe , Wang Youxiao , Liu Gaohuan
Published: January 2021

The Mun River Basin is one of Thailand’s major grain-producing areas, but the production is insufficient, and most of the cultivated lands are rain-fed and always unused in the dry season. All this makes it necessary to determine the status of soil nutrients and soil quality in the dry season to improve soil conditions, which will be useful for cultivation in the farming period. The aim of this study was to construct a soil-quality assessment based on soil samples, and in the process the minimum data set theory was introduced to screen the assessment indicators. The geographically weighted regression method was used to complete the spatial interpolation process of indicators, and the fuzzy logic model was constructed to evaluate the soil quality. The results showed that the spatial distributions of soil quality and indicators were similar. The soil quality was the best in the upstream while poor in the downstream, and the dry fields in the west and the forests in the east of the basin were better than other areas nearby. However; the soil qualities of paddy fields in the middle and east of the basin were poor due to the lack of soil nutrient supply when the fields were unused
Effect of Gabapentin in a Neuropathic Pain Model in Mice Overexpressing Human Wild-Type or Human Mutated Torsin A
Authors: Scuteri Damiana , Rombolà Laura , Natoli Silvia , Pisani Antonio , Bonsi Paola , Watanabe Chizuko , Bagetta Giacinto , Tonin Paolo , Corasaniti Maria Tiziana
Published: January 2021

Background: DYT1 dystonia is the most common form of early-onset inherited dystonia, which is caused by mutation of torsin A (TA) belonging to the “ATPases associated with a variety of cellular activities” (AAA + ATPase). Dystonia is often accompanied by pain, and neuropathic pain can be associated to peripherally induced movement disorder and dystonia. However, no evidence exists on the effect of gabapentin in mice subjected to neuropathic pain model overexpressing human normal or mutated TA. Methods: Mice subjected to L5 spinal nerve ligation (SNL) develop mechanical allodynia and upregulation of the α2δ-1 L-type calcium channel subunit, forming a validated experimental model of neuropathic pain. Under these experimental conditions, TA is expressed in dorsal horn neurons and astrocytes and colocalizes with α2δ-1. Similar to this subunit, TA is overexpressed in dorsal horn 7 days after SNL. This model has been used to investigate (1) basal mechanical sensitivity; (2) neuropathic pain phases; and (3) the effect of gabapentin, an α2δ-1 ligand used against neuropathic pain, in non-transgenic (NT) C57BL/6 mice and in mice overexpressing human wild-type (hWT) or mutant (hMT) TA. Results: In comparison to non-transgenic mice, the threshold for mechanical sensitivity in hWT or hMT does not differ (Kruskal–Wallis test = 1.478; p = 0.4777, although, in the latter animals, neuropathic pain recovery phase is delayed. Interestingly, gabapentin (100 mg/Kg) reduces allodynia at its peak (occurring between post-operative day 7 and day 10) but not in the phase of recovery. Conclusions: These data lend support to the investigation on the role of TA in the molecular machinery engaged during neuropathic pain.
Knowledge Network Embedding of Transcriptomic Data from Spaceflown Mice Uncovers Signs and Symptoms Associated with Terrestrial Diseases
Authors: Nelson Charlotte A. , Acuna Ana Uriarte , Paul Amber M. , Scott Ryan T. , Butte Atul J. , Cekanaviciute Egle , Baranzini Sergio E. , Costes Sylvain V.
Published: January 2021

There has long been an interest in understanding how the hazards from spaceflight may trigger or exacerbate human diseases. With the goal of advancing our knowledge on physiological changes during space travel, NASA GeneLab provides an open-source repository of multi-omics data from real and simulated spaceflight studies. Alone, this data enables identification of biological changes during spaceflight, but cannot infer how that may impact an astronaut at the phenotypic level. To bridge this gap, Scalable Precision Medicine Oriented Knowledge Engine (SPOKE), a heterogeneous knowledge graph connecting biological and clinical data from over 30 databases, was used in combination with GeneLab transcriptomic data from six studies. This integration identified critical symptoms and physiological changes incurred during spaceflight.
The Increase in the Elastic Range and Strengthening Control of Quasi Brittle Cement Composites by Low-Module Dispersed Reinforcement: An Assessment of Reinforcement Effects
Authors: Logoń Dominik , Schabowicz Krzysztof , Roskosz Maciej , Fryczowski Krzysztof
Published: January 2021

This paper presents the possibility of using low-module polypropylene dispersed reinforcement (E = 4.9 GPa) to influence the load-deflection correlation of cement composites. Problems have been indicated regarding the improvement of elastic range by using that type of fibre as compared with a composite without reinforcement. It was demonstrated that it was possible to increase the ability to carry stress in the Hooke’s law proportionality range in mortar and paste types of composites reinforced with low-module fibres, i.e., Vf = 3% (in contrast to concrete composites). The possibility of having good strengthening and deflection control in order to limit the catastrophic destruction process was confirmed. In this paper, we identify the problem of deformation assessment in composites with significant deformation capacity. Determining the effects of reinforcement based on a comparison with a composite without fibres is suggested as a reasonable approach as it enables the comparison of results obtained by various universities with different research conditions.
Fracture Load of an Orthodontic Appliance for Robin Sequence Treatment in a Digital Workflow
Authors: Aretxabaleta Maite , Xepapadeas Alexander B. , Poets Christian F. , Koos Bernd , Spintzyk Sebastian
Published: January 2021

CAD/CAM technologies and materials have the potential to improve the treatment of Robin Sequence with orthodontic appliances (Tübingen palatal plate, TPP). However, studies on the provided suitability and safety are lacking. The present study evaluates CAD/CAM technologies and materials for implementation into the workflow for producing these orthodontic appliances (TPPs), manufactured by different techniques and materials: additive manufacturing (AM) and subtractive manufacturing (SM) technologies vs. conventional manufacturing. The fracture load was obtained in a universal testing machine, and the breaking behavior of each bunch, as well as the necessity of adding a safety wire, was evaluated. The minimum fracture load was used to calculate the safety factor (SF) provided by each material. Secondary factors included manufacturing time, material cost and reproducibility. Dental LT clear showed the highest fracture load and best breaking behavior among AM materials. The highest fracture load and safety factor were obtained with Smile polyether ether ketone (PEEK). For the prototyping stage, the use of a Freeprint tray (SF = 114.145) is recommended. For final manufacturing, either the cost-effective approach, Dental LT clear (SF = 232.13%), or the safest but most expensive approach, Smile PEEK (SF = 491.48%), can be recommended.
Efficient Separation of Photoexcited Charge at Interface between Pure CeO2 and Y3+-Doped CeO2 with Heterogonous Doping Structure for Photocatalytic Overall Water Splitting
Authors: Hou Honghao , Yamada Hirohisa , Nitta Atsumi , Murakami Yoshinori , Saito Nobuo
Published: January 2021

Enhancement of photoexcited charge separation in semiconductor photocatalysts is one of the important subjects to improve the efficiency of energy conversion for photocatalytic overall water splitting into H2 and O2. In this study, we report an efficient separation of photoexcited charge at the interface between non-doped pure CeO2 and Y3+-doped CeO2 phases on particle surfaces with heterogeneous doping structure. Neither non-doped pure CeO2 and homogeneously Y3+-doped CeO2 gave activities for photocatalytic H2 and O2 production under ultraviolet light irradiation, meaning that both single phases showed little activity. On the other hand, Y3+-heterogeneously doped CeO2 of which the surface was composed of non-doped pure CeO2, and Y3+-doped CeO2 phases exhibited remarkable photocatalytic activities, indicating that the interfacial heterostructure between non-doped pure CeO2 and Y3+-doped CeO2 phases plays an important role for the activation process. The role of the interface between two different phases for activated expression was investigated by selective photo-reduction and oxidation deposition techniques of metal ion, resulting that the interface between two phases become an efficient separation site of photoexcited charge. Electronic band structures of both phases were investigated by the spectroscopic method, and then a mechanism of charge separation is discussed.
Simulation Method for the Transport System of a Small-Sized Reconfigurable Mobile Robot
Authors: Vasiliev Andrey , Dalyaev Igor
Published: January 2021

This study focuses on the features of transport (locomotion) systems of mobile mini-robots (MMR), i.e., small unmanned ground vehicles of a portable type measuring several tens of centimeters and weighing no more than 15 kg. A distinctive feature of the considered MMR is the possibility of its both structural reconfiguration (i.e., the ability to function in two options—tracked and wheeled) and geometric reconfiguration in the tracked option (i.e., chassis geometry variation). Thus, the transport system of such a mobile robot is divided into two components: a locomotion subsystem and a chassis geometry variation subsystem. The article examines the factors that are necessary for the correct mathematical description of such a small-sized and relatively high-speed transport system. A method for constructing a computer model of the transport system as an electromechanical device only is proposed. Such a computer model of the MMR transport system is developed for two types of chassis configurations: tracked and wheeled. The experimental studies performed and the comparison of the experimental and simulated data obtained showed their close convergence, within 5 to 7%. Thus, it is shown that the revealed features of the MMR transport systems along with the proposed method for their computer model development considering these features make it possible to increase the accuracy and adequacy of the MMR motion simulation in comparison with previously known approaches used in the computation of larger vehicles. The results obtained make it possible to consider the proposed computer model of the transport system as an electromechanical component of the complete model of a mobile robot.
Surface Texture after Turning for Various Workpiece Rigidities
Authors: Dobrzynski Michal , Mietka Karolina
Published: January 2021

In the paper, we present an analysis of the surface texture of turned parts with L/D (length/diameter) ratios of 6 and 12 and various rigidity values. The studies were carried out on samples made of S355JR steel and AISI 304 stainless steel. A detailed analysis of 2D surface profiles was carried out by using a large number of parameters that allowed us to distinguish significant differences in the surface microgeometry, which confirmed that determining surface characteristics from one height parameter (Ra—arithmetical mean height) is far from sufficient. The obtained results indicate significantly better roughness and waviness values of the AISI 304 steel surfaces in terms of its size, periodicity, and regularity. Therefore, the turning process of AISI 304 shafts with low rigidity allows one to be able to achieve better quality texture and have a positive effect on the general properties of a workpiece. In all tested samples, surface irregularities decreased along with the distance from the tailstock. The shafts with an L/D ratio of 12 had worse surfaces in the first two sections due to lower rigidity. The results received close to the three-jaw chuck, regardless of the L/D ratio and material type, demonstrated similar waviness and roughness parameters and profiles.
Development and Testing of a High-Frequency Dynamometer for High-Speed Milling Process
Authors: Lyu Yanlin , Jamil Muhammad , He Ning , Gupta Munish Kumar , Pimenov Danil Yurievich
Published: January 2021

Cutting forces are strongly associated with the mechanics of the cutting process. Hence, machining forces measurements are very important to investigate the machining process, and numerous methods of cutting forces measurements have been applied. Nowadays, a dynamometer is the most popular tool for cutting forces measurements. However, the natural frequency of a dynamometer has a direct impact on the accuracy of measured cutting forces in the machining process. Therefore, few dynamometers are appropriate and reliable to measure the cutting forces at high frequencies. In this work, a new strain-gauge-based dynamometer (SGBD) with a special structure was designed, manufactured, and put to the test to ensure the measurement of high-frequency dynamic forces in the milling process. The main structure of the SGBD is symmetrical and mainly consists of a center quadrangular prism surrounded by four force sensing elastic elements, an upper support plate, and a lower support plate. The dynamic identification test was conducted and indicated that the SGBD′s natural frequency could be stabilized at a high value of 9.15 kHz. To automatically obtain the milling force data with a computer during high rotational speed milling, a data acquisition system was devised for the dynamometer. To reduce the effects of cross-sensitivity and acting point of force, an innovative model based on a conversion matrix was established for the dynamometer. Furthermore, the cutting tests were conducted at high rotational speeds (10,000–18,000 rpm), and it was found that the difference of cutting forces between the SGBD and a Kistler dynamometer are 2.3–5.8% in the X direction and 3.5–8.8% in the Y direction. The experimental findings disclosed that the new kind of dynamometer is reliably for the measurement of high-frequency dynamic forces in milling at high rotational speeds.
Existence of Absolutely Continuous Fundamental Matrix of Linear Fractional System with Distributed Delays
Authors: Kiskinov Hristo , Madamlieva Ekaterina , Veselinova Magdalena , Zahariev Andrey
Published: January 2021

The goal of the present paper is to obtain sufficient conditions that guaranty the existence and uniqueness of an absolutely continuous fundamental matrix for a retarded linear fractional differential system with Caputo type derivatives and distributed delays. Some applications of the obtained result concerning the integral representation of the solutions are given too.