bluuebunny/crossref_metadata_2025 huggingface dataset:
Genetical structure of populations of modelling species of terrestrial mollusks in conditions of the urbanized landscape on example Сhondrula tridens Müll (Gastropoda, Pulmonata)
Authors: Snegin Eduard A
Published: September 2017

On the basis of the analysis of the morphological and genetical variability revealed by a method of gel-electrophoresis of proteins in PAAG, the state of gene pools of populations of modeling species Сhondrula tridens Müll (threedens snail) in conditions of the urbanized forest-steppe landscape of the south of Mid-Russia Upland is investigated. In the majority of the investigated bunches authentic decrease of a level of heterozygosity and the decrease of an allelic diversification caused, both is fixed by natural historical factors, and factors of an anthropogenic parentage. The genetic-automatic processes in populations are considered and vectors of natural selection are defined. Calculation of effective number of researched bunches is spent.
Gene polymorphism, ecogenetic diseases and predictive personalized medicine
Authors: Baranov Vladislav S
Published: September 2017

The problems concerned with identification of genes involved in the origin of complex diseases, analysis of their epistatic (gene to gene) interactions and adequate interpretation of genetic testing results in Predictive Personalized Medicine (PPM) are reviewed. The practical meaning of already available PPM data, the options and volume of their feasible clinical implications are discussed.
Researching the mechanisms of gene РНО3 regulation de pending on nitrogen source in medium in yeast Sacharomyces cere visiae
Authors: Savinov Vladimir A , Fizikova Anastasia I , Rumyantsev Andrey M , Sambuk Elena V
Published: September 2017

Delicate regulation of gene expression is performed through transcriptional factors competition for promoters that provides punctual cell response to environmental changes. Gene PHO3 of yeast S. cerevisiae encodes the constitutive acid phosphatase. In this work we researched genetic control of the gene PHO3 expression in response to nitrogen source in medium. PHO3 expression level was proved to decrease while yeast using poor nitrogen source like urea. Possible regulatory mechanisms for gene PHO3 were revealed involving repressor of nitrogen regulated genes Gzf3p and ubiquitin ligase Rsp5p
Search for genes encoding potentially amyloidogenic proteins involved in regulation of nonsense -suppresion in Sacharom yces cerevisiae
Authors: Nizhnikov Anton A , Magomedova Zalina M , Sayfitdinova Alsu Faritovna , Inge-Vechtomov Sergey Georgievich , Galkin Aleksey Petrovich
Published: September 2017

Previously, the deletion of SUP35N has been shown to create the genetic background for identification of the novel genes and epigenetic determinants controlling the nonsense-suppression. Here, using a genomic overexpression screen, we have found several genes encoding potentially amyloidogenic proteins, whose overexpression affects the suppressor phenotype in the strain producing the chimeric protein Aβ-Sup35MC on the background of the deletion of SUP35 gene encoding releasing factor eRF 3. It has been demonstrated the NAB2, NAB3 and VTS1 genes participate in the regulation of nonsense-suppression in S. cerevisiae.
Insights into How HIAs are Characterized in the Press: Findings from a Media Analysis of Widely Circulated United States Newspapers
Authors: Gakh Maxim , Coughenour Courtney , Pharr Jennifer , Goodie Aaliyah , To Samantha
Published: September 2017

Background: Health impact assessments (HIAs) are burgeoning tools in the policy process, where the media plays a critical role by focusing attention on issues, informing consumers, and influencing positions. Examining how media portrays HIAs is critical to understanding HIAs in the policy context.

Methods: This study considered how widely circulated, U.S. newspapers represent HIAs. After searching newspaper databases, we used a qualitative document analysis method consisting of open and axial coding to examine specific phrases of HIA depictions. 

Results: In coding over 1,000 unique phrases from the 62 documents generated in our search, we found an uptick in HIA-related publications since 2010. Coding these documents identified 46 distinct codes across 10 different themes. The two most prominent HIA-centered themes focused on HIA engagement and the HIA setting. While themes of policy and science, health determinants, and explanations of HIAs were also frequently featured, specific mentions of projected impacts, HIA processes, HIA values, and health outcomes were less prevalent.

Conclusions: HIA media portrayals warrant further inquiry from researchers and practitioners. Focusing on how media portrays HIAs is consistent with several HIA steps. It is also important for a broader strategy to educate stakeholders about HIAs and to understand HIAs’ utility. HIA practitioners should develop and implement guidelines for media interaction and tracking that encourage practitioners to seek additional media attention and to focus such attention on health impacts and outcomes, HIA recommendations, and HIA values. Building on our work, researchers should examine HIA media portrayals beyond the context of this study.
Lipid profile in patients with coronary heart disease
Authors: Ullewar Milind P. , Ingale Suchita V. , Ingale Vikas C. , Upadhye Jayshree J.
Published: September 2017

Background: The lipid profile and their ratio are important in management and follow up of patients with coronary heart disease. We studied the lipid profile and their ratios with proven coronary artery disease.

Methods: It was retrospective study to determine the lipid profile and their ratios in patients with proven coronary artery disease at Shakuntala Pathology Lab., Nagpur. 200 patients were studied.  

Results: Out of 200 patients studied, 126 (63%) were males while 74 (37%) were females. out of 126 males,12 (9.52%) had raised cholesterol values of >200 mg/dL. 20 (15.87%) had raised triglyceride values of >200 mg/dL. 30 (23.80%) had lower HDL values of <35 mg/dL. 5 (3.96%) had raised LDL values of >150 mg/dL. 90 (71.42%) had raised values of >3.5 for cholesterol to HDL ratio. Out of 74 female patients, 20 (27.02%) patients had raised cholesterol values. 12 (16.21%) patients had raised triglycerides values. 13 (17.56%) patients had lower HDL values. 6 (8.10%) patients had raised LDL values. 50 (67.56%) patients had raised values for cholesterol to HDL ratio.

Conclusions: Our study shows more prevalence of coronary heart disease in males than females. Hypercholesteremia and hypertriglyceridemia was more prevalent in females. HDL values were lowered in more number of males than females. LDL values were raised in more number of females than males. Total cholesterol to HDL ratio was raised in more number of males than females. 

 
Education and Technologies: some Tendencies of this Tehmatic in Educational Research
Authors: Peixoto Joana , Moraes Moema Gomes
Published: September 2017

EDUCAÇÃO E TECNOLOGIAS: ALGUMAS TENDÊNCIAS DA TEMÁTICA NAS PESQUISAS EDUCACIONAIS

Resumo: o presente artigo baseia-se em recorte de pesquisa que visou identificar e analisar o desenvolvimento do tema “educação e tecnologias” nas teses defendidas em programas de pós-graduação em educação entre os anos de 2008 e 2013. Nele discutimos algumas tendências presentes no pensamento educacional brasileiro sobre a temática. O argumento da neutralidade da tecnologia, o discurso tecnocêntrico persistente e a dicotomia entre as visões instrumental e crítica são recorrentes nas fontes consultadas. Adotamos a abordagem dialética para a análise das relações entre a educação e as tecnologias.

Palavras-chave: Educação e tecnologias. Estado do conhecimento. Tecnocentrismo. Abordagem dialética.

Abstract: the present article is grounded in a research clipping which aimed to identify and analyze the development of the subject "education and technologies" in the theses presented in postgraduate programs in education from 2008 until 2013. Here we discuss some tendencies which are present in the Brazilian educational thinking about that matter. The argument of the neutrality of technology, the persistent technocentric discourse and also the dichotomy between the instrumental and the critical visions, they are all recurrent points in our research sources. We adopted the dialectical approach for the analysis of the relations between education and technologies.

Keywords: Education and technologies. Knowledgefare State. Tecnocentrism. Dialectical approach.
The Relationship between HR Expenditure and Firm's Performance: Case of S&P BSE SENSEX 30 Companies
Authors: Talan Gaurav , Sehrawat Kanchan , Sharma Gagan Deep
Published: September 2017

In today’s dynamic business environment, for companies to exist, they must continuously look for areas for improvement and gain competitive advantage. It therefore becomes quintessential for companies to know which factors can have a positive effect on the company’s performance. The purpose of this article is thus to explore if there a relationship between the HR expenses of an Indian company and its financial performance and is this impact positive enough to motivate these companies to augment such efforts in improving the HR management practices. For, this purpose, data on expenditure on human resource and profit after tax (PAT) for BSE- SENSEX 30 companies was extracted for the period of10 years. In order to test the hypothesis of this study, correlation and regression analyses were performed. Results of correlation revealed that HR expenditures are positively related to Firms performance. The findings from regression analysis revealed that HR expenditure have statistically significant effect on a firm’s financial performance.
Algorithm with EIS is Changing the Mindset and Concept of Ownership of Generation Changers Online
Authors: Kesharwani Subodh
Published: September 2017

Online retailers struggle to incarcerate shoppers’ consideration on the basis of their footfall and how this analysis done it is all due to algorithm used. Algorithm in e-commerce playing a very burgeoning role after all, it doesn’t matter if you have a great product in stock but matter how it click to the customers and create a modus-operandi if the right shopper never sees it.
Two Day National Seminar on “Role of Women Self Help Groups on Poverty Alleviation and Empowerment of Women in the Globalised Era”
Authors: Board Editorial , , ,
Published: September 2017

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Теоретические и методологические основы взаимодействия властных и предпринимательских структур
Authors: Кулакова Людмила Ивановна
Published: September 2017

Тема взаимодействия властных и предпринимательских структур давно развивается российскими и зарубежными учеными. Политологи отстаивают позицию такого взаимодействия с точки зрения власти - «бизнес должен». Экономисты придерживаются мнения предпринимателя - «правительство должно». Социологи же склоняются к мнению о социальной ответственности обеих сторон. В настоящей статье рассмотрен генезис формирования походов к определению понятий властная и предпринимательская структура, а так же исторически сложившиеся модели их взаимодействия. Предложен авторский подход к определению «властная структура», «предпринимательская структура», «взаимодействие властных и предпринимательских структур». Обобщены методические подходы к определению сущности взаимодействия властных и предпринимательских структур. Предложен авторский взгляд на механизм взаимодействия властных и предпринимательских структур, базирующийся на отстаивании экономических интересов. В экономических интересах находит свое выражение экономическая необходимость удовлетворения потребностей, которая является конечной целью развития любой экономической системы.
Совершенствование методологии форсайта как инструмента стратегического развития промышленных регионов и отраслей
Authors: Афанасьев Михаил Михайлович
Published: September 2017

В статье затрагивается вопрос о целесообразности развития методологии форсайт-исследований в целях совершенствования возможностей стратегического развития отраслей и компаний отечественной промышленности; предлагается разработанная автором схема проведения форсайт-исследования.
Jual Beli Dengan Hak Membeli Kembali (Studi Komparasi Antara Kitab Undang-Undang Hukum Perdata dan Fikih Syafi’i)
Authors: Fasya Dewi Wulan
Published: September 2017

This article seeks to examine the concept of buying and selling the right to buy back the book review law and civil law bai 'al-Wafa, according to the Shafi'i fiqh. In addition, this article also aims to determine the ratio of the purchase with repurchase review the statute books of civil law and bai al-Wafa, according to the Shafi'i fiqh. Based on the discussion of this article indicates that the purchase is a period of time agreed to recall goods that have been sold and the sale can not be more than five years. While bai 'al-Wafa, according to the Shafi'i fiqh of buying and selling that took sides coupled with the condition that the sale could be bought back by the seller, when the time limit has been determined arrive, while the goods sold are free to be used by the buyer. In sale and purchase of the right to buy back also set about replacement care costs of goods and so forth, while bai 'alWafa there is no mention of the replacement cost of care, which is paid only the cost of the initial purchase, the last of the law of sale and purchase with a repurchase in KUHPerdata much contested in the Supreme court decision which MA. No. 1729 K / Pdt / 2004, which stated that the purchase of the right to buy back is not allowed, while bai 'al-Wafa laws in Shafi'i fiqh books Raghibin Kanz al-Minhaj Fi Sharh al-Thalibin a transaction is fasid.
Artikel ini bertujuan mengetahui konsep jual beli dengan hak membeli kembali tinjauan kitab undang-undang hukum perdata dan bai` al-wafâ menurut fikih Syafi’i. Selain itu, artikel ini juga bertujuan untuk mengetahui perbandingan dari jual beli dengan hak membeli kembali tinjauan kitab undang-undang hukum perdata dan bai` al-wafâ menurut fikih Syafi’i. Berdasarkan uraian pembahasan artikel ini menunjukkan bahwa dalam jual beli ini ada suatu jangka waktu tertentu yang diperjanjikan untuk menebus kembali barang yang telah dijual dan jangka waktu jual beli ini tidak boleh lebih dari lima tahun. Sedangkan bai’ al-wafâ menurut fikih Syafi’i yaitu jual beli yang dilangsungkan dua pihak yang dibarengi dengan syarat bahwa yang dijual itu dapat dibeli kembali oleh penjual, apabila tenggang waktu yang telah ditentukan tiba, sedangkan barang yang dijual tersebut bebas dipergunakan oleh pembeli. Dalam jual beli dengan hak membeli kembali juga mengatur tentang penggantian biaya perawatan barang dan lain sebagainya, sedangkan bai’ al-wafâ tidak ada menyinggung tentang penggantian biaya perawatan, yang dibayarkan hanya harga awal pembelian, terakhir mengenai hukum dari jual beli dengan hak membeli kembali dalam KUHPerdata banyak dipertentangkan dalam putusan Mahkamah Agung diantaranya Putusan MA. No. 1729 K/Pdt/2004 yang menyatakan bahwa jual beli dengan hak membeli kembali tidak diperbolehkan, sedangkan bai’ al-wafâ hukumnya dalam fikih Syafi’i kitab Kanz al-Râghibin Fi Syarh Minhaj al-Thâlibin merupakan jual beli yang fasid
Engagement Cancellation and Its Legal Implication In Malaysia (Woman’s Rights Perspective)
Authors: Fikriyah Uswatul
Published: September 2017

This article aims to describe the legal implication of engagement cancellation in Malaysia and to analyze the woman’s rights protection aspect in Act 303 Islamic Family Law Federal Territory 1984 in Malaysia. This article based on library research focuses on regulation Islamic Family Law Federal Territory Act 303 year 1984 of Malaysia, particularly concerning on about betrothal or Engagement. The result of this study show that the implication of engagement itself could open the opportunities to both of bride and groom to understand and know each other. The implications of engagement cancellation that can be taken from section 15 Act 303 Islamic Family Law Federal Territory. In Islamic family law in Malaysia especially Act 303 Federal Territory Islamic Family Law 1984 women have rights in accordance with their position, namely in the form of rights before marriage, the rights within marriage and the last is the rights after divorce. Women's rights protection aspects contained in the Act 303 Islamic Family Law Federal Territory generally not only in case of engagement cancellation or breach of promise of marriage (bethrothal) but in all the rights of women in marriage. It has the purpose to protect women's rights.
Sakinah Family Concept Based on Jama’ah Tabligh Perspective (Jaulah) in Indonesia
Authors: Ridwan Wirdatuz Zahro’ Afifah
Published: September 2017

This research is field research, descriptive and uses qualitative approach. To get the data, researcher uses 3 data collection methods are observation, interview and documentation. The results of this research, it was found that sakinah family concept based on Jama’ah Tabligh is family that is led by husband who works in da’wah religion sincerely and all the members of family feel peace, always run the commands of Allah and the Sunnah of his Messenger as well as, practice obligatory and sunnah deeds then make Prophet family as minimal model. All member of family must support and remind each other, practice the religion perfectly and always get the blessing of God. they efforts in create sakinah family are by giving religious education for their children, reinforcing the faith, practicing deeds, implementing khuruj fi sabilillah program for husband and masturoh programs to wife regularly, always keeping the communication between husband and wife, discussing to solve the problem. In other hand, member of family should be able to keep other deeds like doing dzikr, recitating, reading important surah like surah Yasin in the morning and doing the duties and obligations as a husband-wife especially educate children and always Istiqomah in charities.
Penelitian ini merupakan penelitian lapangan, bersifat deskriptif dan menggunakan pendekatan kualitatif.Untuk memperoleh data peneliti menggunakan tiga metode pengumpulan data, yakni observasi, wawancara dan dokumentasi. Hasil dari penelitian ini, ditemukan bahwa makna keluarga sakinah menurut Jama’ah Tabligh adalah keluarga yang dipimpin oleh seorang suami yang bekerja dalam da’wah agama secara ikhlas dan seluruh anggota keluarga merasakan ketenangan, selalu menjalankan perintah Allah dan sunah Rasul-Nya serta mengamalkan amalan fardhu dan sunnah serta menjadikan keluarga Rasul sebagai suri tauladan dalam membentuk keluarga sakinah. Seluruh aggota keluarga harus saling mendukung juga dan saling mengingatkan satu sama lainnya, bisa mengamalkan agama secara sempurna serta selalu mendapat ridho dari Allah. Adapun upaya mereka dalam membentuk keluarga sakinah yaitu dengan memberikan pendidikan agama untuk anak-anaknya, mempertebal iman, mengamalkan amalan, melaksanakan program khuruj fi sabilillah untuk suami dan program masturoh untuk istri secara rutin, selalu menjaga komunikasi antara suami istri, musyawarah keluarga dalam menyeleseikan masalah. Selain itu. Anggota keluarga tersebut harus bisa menjaga amalan-amalan sunah lainnya seperti dzikir, tilawah, membaca surat penting, membaca surat yasin di pagi hari dan melaksanakan tugas dan kewajiban sebagai seorang suami istri terutama dalam mendidik anak serta selalu Istiqomah dalam beramal.
KEKUATAN MENGIKAT PERJANJIAN DI BAWAH TANGAN DALAM PEMBIAYAAN BANK SYARIAH
Authors: Fidhayanti Dwi
Published: September 2017

Deed by hand is prepared by parties in a contract personally, and not in the presence of a notary or other official (eg Camat as Land Acquisition Officer) making it difficult to provide legal certainty. The focus of the study in this study, the arrangement of agreements under the hands of the Bank Syariah financing agreement as well as its binding strength. This study is a normative study by examining the juridical construction of the arrangement of agreements under the hand in the financing agreement of Bank Syariah. Bank Syariah financing agreements in Indonesia are based on the Civil Code. This part of the response to the development of new forms in transactions. Agreements which have strong evidentiary power shall be made in writing / Deed. Deed under the hand set forth in articles 1874 - 1984 Civil Code. As long as the parties commit an act of contract law in accordance with the terms of the validity of the agreement (article 1320 Civil Code), then the agreement has a binding legal force as the principle of pact sunt servanda. In QS. Al-Baqarah: 282 requires the recording in carrying accounts payable (financing). The power of binding a covenant either in the form of an authentic deed or deed under the hands of Islamic law is contained in the Qur’an. Al-Maidah: 1 and QS Al-Isra: 34.
El papel de los jueces en el marco de una carta de derechos: Una teoría de la contención judicial = The Role of Courts under a Bill of Rights: A Theory of Judicial Restraint
Authors: Kavanagh Aileen
Published: September 2017

Resumen: Este trabajo tiene un doble objetivo. La primera parte ofrece una visión de conjunto del sistema de derechos configurado en el Reino Unido mediante la Human Rights Act de 1998, donde se trata de mostrar que, a pesar de haber sido descrito como un ejemplo destacado de la revisión judicial “débil” de constitucionalidad, el sistema británico muestra en realidad muchos rasgos de sutil fortaleza. En la segunda parte se toma como referencia la jurisprudencia de los tribunales británicos en el marco de dicha ley, con objeto de articular una teoría de la contención judicial. La conclusión es que, a la hora de determinar la fuerza o debilidad del poder judicial en un determinado sistema de revisión constitucional, necesitamos ir más allá de los mecanismos formales contenidos en los textos para analizar las doctrinas y los recursos que usan efectivamente los jueces cuando revisan la compatibilidad de la legislación con los derechos.Palabras clave: Revisión judicial en materia de derechos humanos, revisión judicial “débil”, supremacía judicial, contención judicialAbstract: The aim of this paper is twofold. First, it provides an overview of the system of the rights-based under the UK Human Rights Act 1998, trying to show that although it is often described as a leading exemplar of ‘weak-form’ constitutional review, in reality, the UK system displays many signs of subtle strength. Second, it adopts the decision making of the English courts under this bill of human rights to elaborate a theory of judicial restraint. The upshot is that when assessing any system of constitutional review in order to determine the strength or weakness of judicial power, we need to look beyond the formal textual mechanisms to explore the doctrines and devices judges use when reviewing legislation for compliance with rights.Keywords: Rights-based judicial review, weak-form judicial review, judicial supremacy, judicial restraint
Constitucionalismo débil = Weak-form judicial review
Authors: Melero de la Torre Mariano C.
Published: September 2017

Resumen: Se suele denominar constitucionalismo “fuerte” al tipo de justicia constitucional predominante después de la segunda gran posguerra, el cual se caracteriza por otorga a los jueces (o a un tribunal especializado) el poder para inaplicar y/o invalidar aquellas leyes que los tribunales consideran contrarias a su interpretación de los derechos protegidos, pudiendo el legislador revocar o modificar las determinaciones judiciales únicamente mediante las mayorías cualificadas que se incluyen en un proceso formal de reforma constitucional. En esta entrada se presentan y discuten varias formas de constitucionalismo “débil”, cuyo rasgo distintivo común consiste en tratar de asegurar la primacía de los derechos básicos sobre el resto del ordenamiento jurídico (incluso mediante su “atrincheramiento” formal), sin asumir la supremacía de los jueces constitucionales en su interpretación. La discusión girará en torno a cuál es el significado preciso de la “debilitación” de los jueces constitucionales y, en consecuencia, cuál debería considerarse la forma más deseable para su articulación institucional.Palabras clave: Supremacía judicial, constitucionalismo débil, revisión judicial basada en derechos, deferencia debida.Abstract: The kind of constitutional justice which has been globally dominant since the end of the Second World War is usually termed ‘strong’ constitutionalism. It gives judges (or a specialized tribunal) the power to strike down legislation that they consider incompatible with their interpretation of those rights and, simultaneously, allows the legislature to override those judicial determinations only by gaining the qualified majorities included in a formal amending process. This entry expounds and discusses some ‘weak’ forms of judicial review, whose common distinctive character is aiming to ensure the supremacy of the basic rights over the rest of the legal system (even with their formal “entrenchment”), without assuming the judicial supremacy in their interpretation. The discussion will revolve around the precise sense of the “weakening” of the courts in a rights-based constitutional review, and which institutional design should be considered its most desirable form.Keywords: Judicial supremacy, weak-form judicial review, rights-based judicial review, due deference
Hecho ilícito internacional = International Wrongful Act
Authors: Sferrazza Taibi Pietro
Published: September 2017

Resumen: En este trabajo se abordará un análisis dogmático de la noción de hecho internacionalmente ilícito en el marco de la responsabilidad internacional del Estado. Sin duda, se trata de una noción clave, dado que su configuración en un caso concreto activa la funcionalidad del resto de los capítulos de la responsabilidad internacional del Estado. En este trabajo se explicará la incidencia que ha tenido la distinción entre normas primarias y normas secundarias para la construcción del concepto de hecho internacionalmente ilícito. Asimismo, se abordará un análisis de cada uno de los dos elementos constitutivos del hecho internacionalmente ilícito, a saber, la ilicitud y la imputabilidad.Palabras clave: Responsabilidad internacional del Estado, hecho internacionalmente ilícito, Comisión de Derecho Internacional, ilicitud, imputabilidad/atribución, normas primarias/normas secundariasAbstract: This paper will deal with a dogmatic analysis of the notion of internationally wrongful acts within the framework of the international responsibility of the State. Undoubtedly, this is a key notion, since its configuration in one case activates the functionality of the rest of the chapters of the State's international responsibility. The paper will explain the impact of the distinction between primary and secondary rules for the construction of the concept of internationally wrongful act. It will also address an analysis of each of the two constituent elements of the internationally wrongful act, namely, breach and attribution.Keywords: International State responsibility, internationally wrongful act, International Law Commission, breach, imputation/attribution, primary rules/secondary rules.
Contratempos e sobressaltos: os eclipses como fenômenos da natureza humana
Authors: Fernandes Renata Sieiro
Published: September 2017

Este artigo mostra alguns desafios metodológicos que surgem no decorrer de uma pesquisa e a busca por novos caminhos. Fala de atos políticos que arruinam o espaço de um projeto educativo do tipo não-formal e provocam sentimenos fortes em seus frequentadores e educadores. Isso inaugura um novo período em que a memória serve como base para as ressignificações tanto do espaço arquietônico como do próprio processo educacional.
La protección del patrimonio cultural material en caso de conflicto armado
Authors: Miranda Gonçalves Rubén
Published: September 2017

La preservación del patrimonio cultural mundial ha ganado mucha atención en los últimos años, pues la destrucción de los bienes culturales ha sido una trágica constante. En este sentido, la Organización de las Naciones Unidas para la Educación, la Ciencia y la Cultura – UNESCO ha reconocido diversas construcciones históricas, conjunto de bienes materiales o naturales como patrimonio cultural y herencia de toda la humanidad, por lo que preservar el patrimonio cultural es extremadamente importante en tanto en cuanto forma parte de la historiografía de diversas generaciones y que contribuye y muestra la historia de nuestros antepasados.
Espaços de construção da interpretação constitucional: análise dos congressos jurídicos da Primeira República
Authors: Galvão Laila Maia
Published: September 2017

O presente artigo parte de uma investigação da interpretação constitucional no decorrer da Primeira República, com especial enfoque à participação dos juristas nesse processo. Observou-se o contexto social e político no qual os juristas estavam inseridos, com destaque para a organização de congressos jurídicos pelo Instituto da Ordem dos Advogados do Brasil. Tais congressos surgiam como novo espaço de articulação de juristas de diversas partes do país para elaboração de teses que serviriam de referência para a intepretação constitucional hegemônica do texto constitucional de 1891.
Hefesto capaz: do mito aos direitos da pessoa com deficiência
Authors: Bentes Hilda Helena Soares
Published: September 2017

Analisa-se, neste artigo, a constituição de um sujeito do direito capaz de respeito e estima, por meio do conceito de capacidade elaborado por Paul Ricoeur a ser aplicado à pessoa com deficiência. Avalia-se o homem capaz, emancipado, que advém da dimensão moral, suscetível de imputação ético-jurídica, conforme expõe Ricoeur no percurso conceitual da hermenêutica da pessoa. A seguir, faz-se uma articulação entre o plano teórico e a referência mítica de Hefesto, deus grego caracterizado pela deformidade e pelas qualidades artísticas. Busca-se, na sequência, uma visão mais alargada do conteúdo do Direito e conclui-se, no plano do reconhecimento jurídico, pelo catálogo de direitos consagrados ao deficiente físico e pelo estado de vigilância necessário para a construção de uma sociedade solidária. Utiliza-se, na abordagem, um método descritivo e conceitual, com aplicabilidade na práxis jurídica.
Determinants of SMEs Performance of the Gem and Jewelry Industry in Thailand: A Pilot Study
Authors: Ahmad Nifaosan Raden , Mohd Shariff Mohd Noor , Hafeez Muhammad Haroon
Published: September 2017

The main purpose of this pilot study is to examine and quantitatively explore a small sample of data on the determinants of strategic orientations and access to finance towards SMEs performance of the Gem and Jewelry Industry in Thailand. The proposed model consists of four elements that are used as a determinant of SMEs performance. A personally administered questionnaire approach was employed to collecting data from firms located in the Jewelry Trade Center, one of the most important premises for trading diamonds, gems, and jewelry in Thailand. The validity and reliability of the instruments were evaluated through panel of experts and data was analyzed using the SmartPLS 2.0.M3 software. The questionnaire revision was made based on the feedback of experts and the results confirmed that the remained items and constructs have good internal consistency reliability. A pilot test shows that there is no issue of validity and reliability of the instrument. The results of pilot test also will be beneficial to the further actual research on a larger scale by helping to avoid the potential research problems.
Fatores antinutricionais da soja crua no crescimento e respostas hematológicas da tilápia do nilo
Authors: MARTINS Graciela Pessoa , PEZZATO Luiz Edivaldo , GUIMARÃES Igo Gomes , PADOVANI Carlos Roberto , MAZINI Bruno Sergio Marques , BARROS Margarida Maria
Published: September 2017

O objetivo do estudo foi avaliar o efeito dietético dos fatores antinutricionais da SC (soja crua) na hematologia e no desempenho produtivo da tilápia-do-nilo (Oreochromis niloticus). Foi realizada a substituição de 0,0; 15,0; 25,0 e 35,0% da proteí­­na do farelo de soja (FS) pela proteí­­na da SC. Neste estudo, foram avaliados o efeito da substituição do FS por SC no perfil hematológico e desempenho produtivo da tilápia após 90 dias experimentais. Foi avaliada a atividade ureática da SC, indicando a presença de fatores antinutricionais. Os parí­¢metros hematológicos (eritrograma e série branca do sangue) foram avaliados. Também foram avaliados os parí­¢metros de desempenho produtivo. A SC afetou o ganho de peso, o consumo de ração e a retenção proteica. Além disso, foram encontrados aumento do número de neutrófilos e diminuição da concentração de albumina. A inclusão de SC na dieta da tilápia alterou o número de células brancas no sangue e prejudicou o desenvolvimento produtivo. No entanto, nenhum efeito sobre o eritrograma foi observado neste estudo. Assim, podemos concluir que, embora os fatores antinutricionais presentes na SC tenham interferido no desempenho produtivo, o ní­­vel de substituição da SC abaixo de 35% é o mais recomendável, por não afetar a saúde dos peixes.
Viabilidade econômica da produção de tambaqui no municí­­pio de Ariquemes-RO
Authors: BELCHIOR Ernandes Barboza , DALCHIAVON Flavio Carlos
Published: September 2017

A elevação da renda das famí­­lias e as condições propí­­cias para a atividade aquí­­cola têm permitido ao Brasil elevar a produção de pescado nos últimos anos. Em razão disso, a produção de tambaqui (Colossoma macropomum) tornou-se alternativa interessante por apresentar adaptabilidade aos diferentes sistemas de produção e grande aceitação pelos consumidores. Ariquemes, RO, destaca-se por apresentar condições logí­­sticas e edafoclimáticas adequadas para produção dessa espécie. Objetivou-se com o presente trabalho analisar a viabilidade econômica da produção de tambaqui em viveiro escavado no municí­­pio de Ariquemes, RO. Analisaram-se financeiramente receitas e despesas em um ciclo produtivo de 420 dias, tendo como referência valores de 2015. A produção de pescado foi suficiente para quitar o Custo Operacional Total. A Margem Lí­­quida foi de R$ 0,44 kg-1 de peixe. Entretanto, a Receita Total foi insuficiente para cobrir o Custo Total, gerando Renda Lí­­quida negativa de R$ 839,57. Contratação de mão de obra e aquisição de ração foram os itens que mais impactaram e responsáveis por 16,1% e 73,7% do Custo Operacional Efetivo, respectivamente. Verificou-se que a produção de tambaqui em viveiro escavado não se mostrou promissora e economicamente viável e tende a se tornar, no longo prazo, insustentável do ponto de vista econômico.
Caracterização da pescaria industrial de espinhel-de-superfí­­cie no Rio Grande do Norte
Authors: LIRA Marcelo Gomes de , NÓBREGA Marcelo Francisco de , LINS OIVEIRA Jorge Eduardo
Published: September 2017

O Rio Grande do Norte (RN) foi o principal exportador brasileiro de atuns e afins durante o perí­­odo de 2006 a 2016, gerando alimento, emprego e renda, haja vista a sua proximidade com as rotas migratórias desses peixes. Visando a um melhor entendimento da diní­¢mica e composição das capturas da frota sediada no RN e que opera com espinhel pelágico no Atlí­¢ntico Sudoeste Equatorial, também foram analisados dados de desembarques entre 2006 e 2014. Cerca de 80% das capturas em peso foram apenas de quatro espécies, sendo 34,1% Thunnus albacares; 30,8% Xiphias gladius; 8,8% Prionace glauca e 6,8% Thunnus obesus. A remuneração da tripulação, combustí­­vel, isca e material de pesca representaram 65% dos custos de produção. Do total exportado pelo Brasil, em peso, o RN foi responsável por aproximadamente 77% de T. albacares fresco e 26% congelado, 92% de T. obesus fresco e 90% congelado e 55% de X. gladius fresco e 95% congelado. Este estudo produziu informações que devem ser levadas em consideração para a sustentabilidade da atividade de pesca de atuns e afins pela frota Potiguar.
The Effect of Exercise and Protein Source on Food Intake Regulation and Characteristics of Metabolic Syndrome in Obese Female Wistar Rats
Authors: Jahan-Mihan Alireza , Magyari Peter , Jenkins Shawna , Palamidy Valeria , Pappas Lindsay , Maier Diana
Published: September 2017

Background: Beneficial effects of dietary proteins and exercise in treatment of obesity is
well-recognized. The effect of exercise and protein source on food intake, body weight and characteristics
of metabolic syndrome in obese female Wistar rats was examined. Female Wistar rats received
an obesogenic diet for 12 weeks. Then, rats were allocated to four groups and received one of the following
treatments for eight weeks: 1- Whey protein Diet + Exercise (WPE), 2- Soy protein diet + exercise
(SPE), 3- Whey protein diet, no exercise (WPN), 4- Soy protein diet, no exercise (SPN). The
exercise comprised of 30 minutes on a treadmill, three times/week. Body weight (BW) and food intake
(FI), blood pressure, pulse, glucose and intake regulatory hormones were measured.

Results:

FI and plasma ghrelin (2.7 times) were higher in exercise groups compared with non-exercise
groups. BW was lower (6.7%) in groups fed a whey protein diet compared with those fed a soy protein
diet. Abdominal fat (% BW) was lower (22.8%) in WPE compared with other groups. Diastolic blood
pressure (11.1%) and pulse (6%) were lower in groups fed a soy protein diet compared with groups
fed a whey protein diet.

Conclusion:

While exercise affects food intake, source of protein determines BW and BC. Whey protein
showed more favorable effect on BW and body composition.
Anticancer Evaluation and Docking Study of New Bifunctional Phthalazine Derivatives
Authors: El-Gazzar Marwa G. , Aly Hala M.
Published: September 2017

Aims and Objective: A series of novel phthalazine derivatives was synthesized with versatile, readily
accessible electrophilic and nucleophilic reagents. The newly synthesized compounds were confirmed by
the results of spectroscopic measurements. Hence, their potential clinical application investigated in particular
for cancer treatment.

Materials and Methods:

The newly synthesized compounds were characterized by spectroscopic measurements
and were tested for their in vitro anticancer activity by MTT assay against human liver cancer cell line.
Docking study of all the synthesized compounds was performed within the active site of the enzyme VEGFR-2
(Vascular Endothelial Growth Factor Receptor-2).

Results:

The quinazoline derivative 12 emerged as the most potent compound in this study with an IC50 value
of 5.4 µM. Docking study showed that the synthesized compounds were fit in the VEGFR-2 active site almost
at the same position of sorafenib and vatalanib with comparable docking scores (-15.20 to -8.92 was kcal/mol).

Conclusion:

we have synthesized a novel series of phthalazine derivatives and evaluated their potential anticancer
activity against HEPG2 cell line. The quinazoline derivative 12 emerged as the most potent compound
in this study with an IC50 value of 5.4 µM. The SAR and docking studies pointed out that rigidification of the
structure resulted in better activity and better binding within the active site of VEGFR-2 as in compounds 3, 5,
6 and 12. These results introduced new phthalazine derivatives having promising activity which could lead to
the development of more potent anticancer agents.
Overview of Wind Energy Conversion Systems and Flexible AC Transmission Systems
Authors: Abu-Siada Ahmed , Masoum Mohammad A. S. , Alharbi Yasser , Shahnia Farhad , Shiddiq Yunus A. M.
Published: September 2017

Flexible AC transmission system (FACTS) is a technology that consists of a
variety of power electronic devices which was developed with the aim of controlling
both power and voltage at certain locations of the electricity grids during disturbances,
improving the existing transmission line capacity and providing a controllable power
flow for a selected transmission direction. This chapter provides a general overview for
variable FACTS devices, concepts and topologies. It also provides brief information
about various wind energy conversion systems.
Applications of Unified Power Flow Controller in Wind Energy Conversion System
Authors: Abu-Siada Ahmed , Masoum Mohammad A. S. , Alharbi Yasser , Shahnia Farhad , Shiddiq Yunus A. M.
Published: September 2017

Unified power flow controller (UPFC) is one of the Flexible ac Transmission System (FACTS) devices that possess the ability of modulating both active and reactive power at the point of common coupling in four quadrant operational modes. This chapter illustrates UPFC topology, controllers with some case studies for various applications of UPFC in the DFIG-based WECS. New applications for UPFC are proposed to improve the overall performance of a DFIG-based WECS during voltage sag and voltage swell events at the grid side.
First report of biovar 6 in birds immunized against Gallibacterium anatis in poultry farms located in Sonora, Mexico.
Authors: Osuna Chávez Reyna Fabiola , Molina Barrios Ramón Miguel , Hernández Chávez Juan Francisco , Robles Mascareño Jorge , Icedo Escalante Jesús Gabriel Adrián , Acuña Yanes Martín
Published: September 2017

Identification of the predominant circulating biovars is important for controlling Gallibacterium anatis infections in poultry because efficient protection is based on the use of biovar-specific immunogens. Twenty-three isolates of Gallibacterium anatis were recovered from commercial laying hens with respiratory and reproductive clinical signs. Bacteria were identified as G. anatis based on morphology, biochemistry, and PCR testing. Biochemical analyses identified the isolates as biovar 6 which had not previously been reported in Sonora, México. Therefore, the recent finding of biovar type 6 could explain clinical presentations of this disease in immunized commercial laying flocks in Sonora.Figure 1. PCR amplification gene, Gallibacterium anatis.
Оптимізація лікування дітей з інфекцією дихальних шляхів, які мають алергічний риніт
Authors: Kryvopustov S.P.
Published: September 2017

Оптимізація лікування як гострих вірусних інфекцій респіраторного тракту, так і алергічних захворювань є вкрай актуальним завданням сучасної педіатрії. Існує взаємозв’язок між алергією дихальних шляхів та вірусною інфекцією. З одного боку, при алергії збільшується ризик розвитку інфекції, а з іншого — сама вірусна інфекція може ініціювати загострення алергічних проявів з боку респіраторного тракту. Показана доцільність використання антигістамінного препарату L-цет сироп (левоцетиризину дигідрохлориду) в лікуванні тих дітей з інфекцією дихальних шляхів, які мають ще й алергічний риніт, а це спостерігається нерідко. Левоцетиризин є лівообертальним ізомером антигістамінного препарату другого покоління цетиризину й має вдвічі вищу спорідненість до H1-рецепторів порівняно з ним. Крім того, що левоцетиризин є конкурентним антагоністом Н1-гістамінових рецепторів, він пригнічує вироблення молекул міжклітинної адгезії ICAM-1 і реплікацію риновірусу, має протизапальні та імунорегуляторні властивості.
Атопічний марш у педіатрії: генотип-асоційовані механізми Частина 2. Перспективні генотип-асоційовані механізми та маркери хвороб атопічного маршу в дітей
Authors: Dytiatkovsky V.O.
Published: September 2017

В огляді наведені дані досліджень за останні 10 років у популяціях різних країн щодо асоціацій атопічних хвороб, що становлять атопічний марш у дітей (атопічного дерматиту, алергічного риніту, алергічного ринокон’юнктивіту та бронхіальної астми), і патологічних мутацій генів (однонуклеотидних поліморфізмів, single nucleotid poymorphysms — SNP), які кодують синтез молекул, що беруть участь у алергічному запаленні на шкірі та слизових оболонках. Як пошукову систему було застосовано PubMed. Наданий аналіз досліджень генів-кандидатів алергічного запалення — інтерлейкін-1-подібного рецептора-1, сфінголіпідного регулятора біосинтезу, гена глюкокортикостероїдних рецепторів, гена запрограмованої клітинної смерті 4. Наведено нові маркери-кандидати тяжкості перебігу атопічних хвороб, зокрема атопічного дерматиту: вітамін D3, тимус, активацією регульований хемокін TARC/CCl17 та шкірний Т-атрактивний хемокін CTAC/CCL27. Запропоновано проведення досліджень вищенаведених SNP і маркерів алергічного запалення на українській педіатричній популяції для розробки персоналізованого генотип-асоційованого підходу до діагностики та лікування атопічних хвороб у дитячого населення України.
Людський сироватковий альбумін (минуле та майбутнє)
Authors: Klygunenko O.M. , Zozulya O.O.
Published: September 2017

У лекції висвітлюються поняття та структура, основні функції та особливості застосування розчинів людського сироваткового альбуміну при лікуванні хворих із критичними станами.
Кардіопротективні властивості торакальної паравертебральної блокади в гострому періоді закритої торакальної травми різного ступеня тяжкості
Authors: Muryzina O.Yu. , Klygunenko E.N.
Published: September 2017

Вступ. Адекватність аналгезії при тяжкій закритій торакальній травмі (ЗТТ) забезпечується регіонарними методами знеболювання, одним із яких є торакальна паравертебральна блокада (ТПБ), яка вже довела свою ефективність. Проте не наведені дослідження впливу ТПБ на перебіг саме ушкодження серця після ЗТТ. Мета. Виявлення впливу ТПБ, проведеної в гострому періоді ЗТТ, на перебіг первинних і вторинних травматичних ушкоджень серця. Матеріали та методи. Контрольоване проспективне нерандомізоване дослідження засновано на аналізі лікування 82 постраждалих із ЗТТ: 70 (85,4 %) чоловіків, 12 (14,6 %) жінок, віком 53 (45, 65) роки. Групи сформовані за тяжкістю ЗТТ, де у підгрупах («a», «b») порівнювалася ефективність системної аналгезії (нестероїдні протизапальні засоби (НПЗЗ) та опіоїд) і ТПБ, проведеної у гострому періоді й надалі упродовж 4–5 діб. 1-ша групa — Injury Severity Score (ISS) — 16,0 ± 4,4 бала, APACHE II — 11,7 ± 3,6; 2-га група — ISS — 17,1 ± 3,9 бала, APACHE II — 13,8 ± 4,1; 3-тя група — ISS — 18,5 ± 4,9 бала, APACHE II — 14,5 ± 2,3. Результати. ЗТТ (ISS — 18 (14, 20) балів) із контузійним ушкодженням легенів І і ІІ ступеня у 62 (76 %) постраждалих (у 22 % виявлено на 1-шу добу, у 79 % — на 2-гу — 3-тю добу) ускладнювалася струсом чи забоєм серця до 70 % спостережень, післятравматичною міокардіо­дистрофією у ранньому та відновлювальному періодах — майже в усіх постраждалих. На електрокардіограмі (ЕКГ) — субендокардіальні та субепікардіальні зміни, пробіжки тахікардії, екстрасистоли, неспецифічні зміни кінцевої частки шлуночкового комплексу, ознаки інфаркту міокарда травматичного походження, а також і ІІ типу через крововтрату (у 2 пацієнтів). Не виявлено різниці ЕКГ-ознак між гемодинамічно стабільними і нестабільними пацієнтами. Застосування НПЗЗ та опіоїду (n = 43, підгрупи «а») достатньою мірою не усувало біль і гіпоксемію, зберігався периферичний вазоспазм (загальний периферичний судинний опір (ЗПСО) — 1987 ± 159 дин/с · см2), тахікардія (86 ± 13 уд · хв–1), зменшення роботи серця (серцевий індекс (СІ) — 2,71 ± 0,27 л/м2 · хв). Застосування ТПБ (n = 39, підгрупи «b») одразу знижувало біль на 68 ± 7 %, забезпечувало ліпше SрО2 95,6 ± 1,7 % проти 94,1 ± 1,5 % та РаО2/FіО2 340 ± 25 проти 312 ± 50 у підгрупах «а», що поєднувалось зі зменшенням тахікардії (80 ± 7 уд · хв–1) та периферичного судинного опору (ЗПСО — 1692 ± 157 дин/с · см2; p = 0,01) при одночасному сприятливому збільшенні продуктивності серцевої діяльності (СІ — 3,1 ± 0,17 л/м2 · хв). На 5-ту добу на фоні ТПБ РаО2/FiО2 був вищий, ніж у підгрупах «а» — 380 ± 28 % проти 362 ± 27 %; SрО2 — 96,8 ± 0,7 % проти 95,1 ± 1,1 % (p = 0,02). Висновки. ТПБ, проведена одразу в гострому періоді ЗТТ через усунення болю і гіпоксемії, має кардіопротекторну дію, що виявляється в антиаритмічному та протиішемічному ефектах, запобігаючи ускладненому перебігу струсу чи забою серця, зменшуючи прояви первинної і вторинної посттравматичної міокардіодистрофії.
Вплив комбінованої нейрометаболічної терапії на регрес неврологічної симптоматики у хворих із гострим ішемічним інсультом
Authors: Kushch K.O. , Klygunenko O.M. , Zozulya O.O.
Published: September 2017

Досліджено ефективність комбінованої нейрометаболічної терапії у хворих із гострим порушенням мозкового кровообігу за ішемічним типом. Доведено, що застосування комбінації препаратів, що впливають на холінергічну систему, прискорює відновлення свідомості, зменшує неврологічний дефіцит та зберігає когнітивний статус.