bluuebunny/crossref_metadata_2025 huggingface dataset:
GIẢM SỐ LƯỢNG TIỂU CẦU Ở BỆNH NHÂN NHIỄM TRÙNG HỆ THỐNG
Authors: Nguyễn Văn Trọng , Đặng Quốc Tuấn , Nguyễn Anh Tuấn , Lưu Tuấn Việt
Published: April 2023

Mục tiêu: Mô tả tỷ lệ, mức độ nặng, diễn biến, kết quả điều trị giảm số lượng tiểu cầu ở bệnh nhân nhiễm trùng hệ thống (sepsis) tại trung tâm Hồi sức tích cực. Đối tượng: 307 bệnh nhân sepsis có giảm tiểu cầu tại trung tâm Hồi sức tích cực bệnh viện Bạch Mai từ tháng 9 năm 2021 đến tháng 7 năm 2022. Phương pháp: Nghiên cứu mô tả, bệnh nhân được ghi lại các thông số về số lượng tiểu cầu, thời gian giảm tiểu cầu, vị trí nhiễm khuẩn, kết cục lâm sàng. Kết quả: Có 307 bệnh nhân được đưa vào nghiên cứu. Viêm phổi là nhiễm khuẩn thường gặp nhất (40%). Thời gian giảm tiểu cầu trung bình là 6,4 ngày. Phần lớn giảm tiểu cầu mức độ trung bình và nặng. Tỷ lệ tử vong/Nặng xin về ở nhóm bệnh nhân giảm tiểu cầu có sepsis/sốc nhiễm khuẩn và DIC khác biệt có ý nghĩa thống kê với nhóm sepsis/sốc nhiễm khuẩn không có DIC với OR 3,064, P < 0,05. Kết luận: Giảm tiểu cầu là phổ biến và có liên quan đến kết quả lâm sàng tồi tệ hơn. Như vậy, giảm tiểu cầu khi nhập viện hoặc khi bắt đầu sốc nhiễm trùng ở bệnh nhân nhiễm trùng có thể được sử dụng như một dấu hiệu sớm cho phân tầng rủi ro để xác định bệnh nhân có nguy cơ lâm sàng phức tạp và tăng tỷ lệ tử vong. Các bác sĩ nên tích cực trong chẩn đoán và điều trị nguyên nhân của giảm tiểu cầu ở bệnh nhân sốc nhiễm trùng để cải thiện kết cục lâm sàng.
THỰC TRẠNG BỆNH MŨI HỌNG Ở NGƯỜI LAO ĐỘNG MỎ THAN PHẤN MỄ, THÁI NGUYÊN
Authors: Lê Thị THanh Hoa , Nguyễn Đức Anh , Trương Thị Thùy Dương , Nguyễn Ngọc Anh
Published: April 2023

Mục tiêu: Mô tả thực trạng bệnh mũi họng ở công nhân mỏ than Phấn Mễ, Thái Nguyên năm 2022. Phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang trên 294 người lao động trực tiếp tại mỏ than Phấn Mễ, tỉnh Thái Nguyên từ tháng 01/2021 đến tháng 11/2022. Kết quả: Tỉ lệ mắc bệnh mũi họng 62,9%. Bệnh lý họng thanh quản mạn tính 41,8% và bệnh lý mũi xoang mạn tính 25,2%. Các triệu chứng lâm sàng chính là ngạt mũi 23,8%, tắc mũi 19%, chảy nước mũi 24%, ho (41,8%), đau họng (39,8%), ngứa họng (6,1%). Niêm mạc mũi nhợt có tỉ lệ 12,2%. Amidan có hốc 5,4% quá phát 2,7%, thành sau họng có hạt chiếm 20%, xung huyết 2,7% và sưng nề 1,7%. Có 25,9% công nhân mắc mới bệnh lý mũi họng trong năm 2022. Kết luận: Tỉ lệ mắc bệnh mũi họng ở công nhân mỏ than Phấn Mễ tương đối cao, chiếm 62,9%. Đa số công nhân mắc bệnh mũi họng mạn tính.
NGHIÊN CỨU MỘT SỐ YẾU TỐ ẢNH HƯỞNG ĐẾN KẾT QUẢ ĐIỀU TRỊ PHẪU THUẬT CHẢY MÁU DƯỚI NHỆN DO VỠ PHÌNH ĐỘNG MẠCH NÃO GIỮA
Authors: Nguyễn Quang Thành , Nguyễn Thế Hào , Phạm Quỳnh Trang , Phạm Văn Cường , Vũ Tân Lộc
Published: April 2023

Mục tiêu: Nghiên cứu các yếu tố ảnh hưởng đến kết quả điều trị phẫu thuật chảy máu dưới nhện do vỡ phình động mạch não giữa. Phương pháp nghiên cứu: Nghiên cứu hồi cứu 41 bệnh nhân chảy máu dưới nhện do vỡ phình động mạch não giữa phẫu thuật tại Bệnh Viện Bạch Mai từ tháng 06 năm 2021 đến tháng 06 năm 2022. Kết quả: 41 bệnh nhân tuổi trung bình 55,9 ± 11,9, tỷ lệ nam: nữ » 2:3. Các yếu tố có ảnh hưởng đến kết quả phẫu thuật: Đặc điểm bệnh nhân; Nhóm dưới 30 tuổi tỷ lệ tốt 100%, Nhóm tuổi trên 60t tỉ lệ tốt 41,7%; Độ lâm sàng: Kết quả điều trị tốt độ I 100%, xấu (độ IV,V) lần lượt 23,5% và 60%; Đặc điểm hình ảnh: Mức độ chảy máu dưới nhện theo Fischer cải tiến độ I,II kết quả tốt lần lượt 100% và 75%, độ III,IV kết quả xấu lần lượt 7,2% và 33,4%. Kích thước túi phình nhỏ kết quả điều trị tốt 63,6%, túi phình lớn kết quả trung bình 42,1% và xấu 31,6%. Kích thước cổ túi phình hẹp kết quả tốt 66,7%, rộng kết quả trung bình 52,5% và xấu 29,5%; Đặc điểm phẫu thuật: Vỡ trong mổ kết quả trung bình và xấu 33,3% và 50%, không vỡ kết quả tốt 58,6%. Kẹp động mạch mang tạm thời: Không kẹp kết quả tốt 62,5%, có kẹp kết quả tốt 20% và xấu 28%. Kết luận: Kết quả điều trị tốt gặp nhiều hơn ở nhóm bệnh nhân có độ tuổi thấp, tình trạng lâm sàng trước phẫu thuật tốt, phân độ CMDN theo Fischer thấp, kích thước túi phình nhỏ, cổ túi phình hẹp, bệnh nhân không có vỡ túi phình trong mổ hoặc kẹp động mạch mang tạm thời trong mổ.
NGHIÊN CỨU ĐẶC ĐIỂM X.QUANG RĂNG KHÔN HÀM DƯỚI TRÊN PHIM CẬN CHÓP Ở SINH VIÊN HỌC VIỆN QUÂN Y NĂM THỨ 3, NĂM HỌC 2022-2023
Authors: Nguyễn Trọng Đức , Nguyễn Khang , Trương Thị Mai Anh
Published: April 2023

Mục tiêu: Phân tích đặc điểm hình ảnh răng khôn hàm dưới (RKHD) trên phim X.Quang cận chóp ở sinh viên năm thứ 3 Học viện Quân y, năm học 2022-2023. Phương pháp nghiên cứu: 151 học viên dài hạn quân y năm thứ 3, năm học 2022-2023 được đánh giá RKHD trên phim chụp cận chóp tại Bộ môn – Khoa Răng miệng, Bệnh viện Quân y 103 từ tháng 2 đến tháng 3 năm 2023. Kết quả: Trong 222 RKHD, có 108 mọc lệch bên phải (chiếm 48,65%), 114 mọc lệch bên trái (chiếm 51,35%). Ở cả RKHD bên phải và bên trái, hướng mọc lệch gần chiếm tỷ lệ cao nhất (56,29% ở bên phải và 53,64% ở bên trái). Hình dạng chân răng với hai chân dạng xuôi chiều chiếm chủ yếu (57,41% ở bên trái và 50,89% ở bên phải). Không có sự khác biệt có ý nghĩa thống kê về giá trị kích thước RKHD trung bình giữa bên phải và bên trái. Kết luận: Nghiên cứu đã đưa ra bằng chứng về đặc điểm X.Quang của RKHD trên phim chụp cận chóp ở sinh viên Học viện Quân y khóa học 2022-2023 là cơ sở cho định hướng điều trị trên lâm sàng.
Reforma procesal para la implantación de la nueva oficina judicial: una primera aproximación crítica
Authors: Atienza López José Ignacio
Published: April 2023

El presente trabajo realiza un primer análisis crítico acerca de la importante reforma orgánica y procesal que va a suponer la llamada nueva oficina judicial, desde la perspectiva de los secretarios judiciales como funcionarios considerados esenciales por la propia norma para la implantación de tal oficina. Resulta especialmente relevante la problemática derivada de la nueva distribución de competencias entre jueces y secretarios judiciales, al establecer la nueva norma una separación de las mismas de mayor claridad. Igualmente se aborda la dificultad de determinar con la nueva norma cuáles han sido los criterios delimitadores para esa separación de funciones entre ambos tipos de funcionarios y las razones por las que, habiendo sido otorgadas al secretario judicial funciones de naturaleza claramente jurisdiccional, no se reconoce por la norma este extremo ni sus posibles consecuencias.
También es objeto de análisis la llamada agenda de señalamientos como aspecto principal de discrepancia de la carrera judicial en relación con la reforma operada y la pretensión de dicha carrera de vincular la agenda con su independencia judicial. Finalmente se abordan los aspectos más relevantes acerca de las competencias que el secretario judicial asume en la ejecución civil, así como las dificultades que habrán de presentarse durante el periodo transitorio de aplicación de la nueva norma, que se adivina muy prolongado en el tiempo. Finalmente se destaca en este trabajo la necesaria independencia que los secretarios judiciales deben defender en sus nuevas competencias al tener suficiente cobertura legal para ello.
Las medidas cautelares en la Ley de 13 de julio de 1998 reguladora de la jurisdicción contencioso-administrativa. Especial referencia a las medidas cautelares inaudita parte
Authors: Roig Mateo Betlem
Published: April 2023

El presente trabajo no pretende aportar novedades sustanciales en lo que se refiere a las medidas cautelares en el orden contencioso-administrativo, pero sí plantear al lector la duda de por qué no son utilizadas con la profusión con la que son interesadas y acordadas en otros órdenes jurisdiccionales.
Dirijo también mi atención al derecho a la tutela judicial efectiva y me hago eco de numerosas resoluciones judiciales en las que se concluye que el derecho a la tutela cautelar forma parte de la tutela judicial efectiva recogida en el artículo 24 de la Constitución Española.
Después de una introducción en la que se recuerdan los requisitos que exige toda medida cautelar, adentraré al lector en la Ley reguladora de la Jurisdicción Contencioso-Administrativa para ver qué trato se ha dispensado a las medidas cautelares en este orden jurisdiccional, ayudándome de la jurisprudencia existente en la materia y empleando el término jurisprudencia en el más amplio sentido posible, pues podrá observarse cómo, además de a resoluciones del Tribunal Supremo, hago mención a resoluciones de órganos inferiores que conforman la denominada jurisprudencia menor.
El siguiente paso será examinar el trato que la jurisprudencia ha dispensado a las denominadas medidas cautelares inaudita parte recogidas en el artículo 135 de la Ley 29/1998, de 13 de julio.
En esta última cuestión, revisten especial interés los requisitos que exigen los Tribunales para acordar dichas medidas cautelares y muy curiosa es también la extrema cautela con la que son interesadas y en su caso acordadas.
La transmisión de derechos de emisión y sus derivados
Authors: González Sánchez Sara
Published: April 2023

Este trabajo ha obtenido el 2.º Premio Estudios Financieros 2010 en la modalidad de DERECHO CIVIL Y MERCANTIL.
La ratificación de la Convención Marco de las Naciones Unidas sobre el Cambio Climático y el Protocolo de Kioto obliga a España a reducir sus emisiones de gases de efecto invernadero a la atmósfera. En el elenco normativo dispuesto a tal efecto –principalmente, la Ley 1/2005, de 9 de marzo, de Comercio de Derechos de Emisión de Gases de Efecto Invernadero– no se ha establecido el régimen de Derecho privado aplicable al mercado de derechos de emisión. Ante dicha omisión, han sido los agentes económicos quienes han desarrollado distintos usos o formas de transmisión y negociación de derechos de emisión y de instrumentos financieros derivados sobre los mismos. En este trabajo se realiza un análisis jurídico-mercantil de la transmisión de los derechos de emisión y sus derivados con el fin de lanzar propuestas de modificación normativa que protejan a todos los intervinientes en el mercado de derechos de emisión, tanto si se trata de empresarios afectados por la aplicación de la Ley 1/2005 como de cualquier inversor en derechos de emisión.
Las agencias de rating como terceros de confianza: responsabilidad civil extracontractual y protección de la seguridad del tráfico
Authors: Alba Fernández Manuel , Rodríguez de las Heras Ballell Teresa
Published: April 2023

Este trabajo ha obtenido el Accésit Premio Estudios Financieros 2010 en la modalidad de DERECHO CIVIL Y MERCANTIL.
Los recientes acontecimientos que han marcado la actualidad de los mercados financieros internacionales han dotado de inesperado protagonismo a un conjunto de figuras de variado perfil que comparten una función esencial: la generación de confianza en los mercados mediante la transmisión de información especializada, creíble y precisa sobre los operadores económicos (emisores) y ciertas emisiones. El papel de las entidades o agencias de rating, cuyo perfil funcional ha evolucionado desde su clásica condición de terceros de confianza hasta su posición actual como auténticos gatekeepers, ha despertado además especial atención por su dudosa intervención en el desarrollo de la crisis financiera. En este contexto, el debate sobre la idoneidad de recurrir a mecanismos de control de mercado, o a técnicas de regulación parecía haberse decantado, primero, por una clara apuesta por la autorregulación. La sofisticación funcional de las agencias como suministradoras ya no sólo de variables decisorias sino de verdaderos «inputs regulatorios» ha reenfocado la regulación hacia modelos de acreditación o registro y supervisión directa. Se abre así un interesante espacio para el análisis, primero, sobre la función de los terceros de confianza en los mercados internacionales, y, segundo, sobre el papel de las reglas generales sobre responsabilidad civil patrimonial que, en medida alguna, sirvan para proteger los intereses de quienes confían en los ratings como variables determinantes en su proceso de toma de decisiones de inversión.
Recursos de um professor da EJA-Campo para ensinar matemática em aulas remotas e presenciais
Authors: Silva Josias Pedro da , Lima Iranete Maria da Silva
Published: April 2023

Este artigo traz uma parte de uma pesquisa de doutorado4 que objetiva identificar os recursos de um professor da EJA-Campo para ensinar matemática no ensino remoto e no retorno ao ensino presencial. Com base na metodologia de investigação reflexiva, no quadro da Abordagem Documental do Didático, realizamos uma entrevista semiestruturada com um professor, solicitamos a ele que gravasse um vídeo para apresentar os recursos disponíveis na escola e que construísse uma representação esquemática dos seus recursos. A análise dos dados mostrou, conforme esperado, que a maioria dos recursos do professor para o ensino remoto estão relacionados às Tecnologias Digitais da Informação e Comunicação, embora também utilizasse atividades impressas em papel em razão da precariedade do acesso à internet na área rural. Além desses, recursos como dominó, ábaco, material dourado e relatos dos alunos sobre suas atividades profissionais foram citados entre os recursos para o ensino presencial.
¿Qué significa aprendizaje colectivo? ¿Cómo lograrlo en la clase de matemáticas?
Authors: Radford Luis
Published: April 2023

Neste artigo, abordo a questão do que significa aprendizagem coletiva e como ela pode ser fomentada na sala de aula de matemática. Sugiro que a proximidade espacial (real ou virtual) não é um critério suficiente para caracterizar a aprendizagem coletivo. Os alunos podem estar juntos fechados dentro das quatro paredes de uma sala de aula (real ou virtual) sem aprender coletivamente. Caracterizar a aprendizagem coletiva requer rever a ideia de atividade na qual ocorre a aprendizagem coletiva. Com base nos principais insights da teoria da objetivação, sugiro que tal atividade tem que atender a duas condições. Primeiro, ela deve ser direcionada para a satisfação de uma necessidade coletiva: alcançar um objeto comum de aprendizagem que seja progressivamente revelado à consciência dos alunos através do labor conjunto com o professor. Em segundo lugar, a atividade é desenvolvida por meio de uma interação entre alunos e entre alunos e professores que se sustenta em relações sociais de um tipo ético especial: relações sociais de uma ética comunitária que inclui compromisso, cuidado com o outro e responsabilidade. Estas ideias são apresentadas com base em exemplos na aula de matemática.
Towards Interpretable LSTM-based Modelling of Hydrological Systems
Authors: De la Fuente Luis Andres , Ehsani Mohammad Reza , Gupta Hoshin Vijai , Condon Laura E.
Published: April 2023

Abstract. Several studies have demonstrated the ability of Long Short-Term Memory (LSTM) machine learning based modeling to outperform traditional spatially lumped process-based modeling approaches for streamflow prediction. However, due mainly to the structural complexity of the LSTM network (which includes gating operations and sequential processing of the data), difficulties can arise when interpreting the internal processes and weights in the model. Here, we propose and test a modification of LSTM architecture that represents internal system processes in a manner that is analogous to a hydrological reservoir. Our architecture, called HydroLSTM, simulates behaviors inherent in a dynamic system, such as sequential updating of the Markovian storage. Specifically, we modify how data is fed to the new representation to facilitate simultaneous access to past lagged inputs, thereby explicitly acknowledging the importance of trends and patterns in the data. We compare the performance of the HydroLSTM and LSTM architectures using data from 10 hydro-climatically varied catchments. We further examine how the new architecture exploits the information in lagged inputs, for 588 catchments across the USA. The HydroLSTM-based models require fewer cell states to obtain similar performance to their LSTM-based counterparts. Further, the weights patterns associated with lagged input variables are interpretable and consistent with regional hydroclimatic characteristics (snowmelt-dominated, recent rainfall-dominated, and historical rainfall-dominated). These findings illustrate how the hydrological interpretability of LSTM-based models can be enhanced by appropriate architectural modifications that are physically and conceptually consistent with our understanding of the system.
DQPB: software for calculating disequilibrium U–Pb ages
Authors: Pollard Timothy , Woodhead Jon , Hellstrom John , Engel John , Powell Roger , Drysdale Russell
Published: April 2023

Abstract. Initial radioactive disequilibrium amongst intermediate nuclides of the U decay chains can have a significant impact on the accuracy of
U–Pb ages, especially in young samples. For samples that can reasonably be assumed to have attained radioactive equilibrium at the
time of analysis, a relatively straightforward correction may be applied. However, in younger materials where this assumption is unreasonable, it is necessary to replace the familiar U–Pb age equations with more complete expressions that account for growth and decay of intermediate nuclides through time. DQPB is software for calculating U–Pb ages while accounting for the effects of radioactive disequilibrium among intermediate nuclides of the U decay chains. The software is written in Python and distributed as both a pure Python package and a stand-alone graphical user interface (GUI) application that integrates with standard Microsoft Excel spreadsheets. The software implements disequilibrium
U–Pb equations to compute ages using various approaches, including concordia intercept ages on a Tera–Wasserburg diagram,
U–Pb isochron ages, Pb*/U ages based on single aliquots, and 207Pb-corrected ages. While these age-calculation
approaches are tailored toward young samples that cannot reasonably be assumed to have attained radioactive equilibrium at the time of analysis,
they may also be applied to older materials where disequilibrium is no longer analytically resolvable. The software allows users to implement a
variety of regression algorithms based on both classical and robust statistical approaches, compute weighted average ages and construct
customisable, publication-ready plots of U–Pb age data. The regression and weighted average algorithms implemented in DQPB may also be applicable to other (i.e. non-U–Pb) geochronological datasets.
Simulating one century (1902–2009) of river discharges, low flow sequences and flood events of an alpine river from large-scale atmospheric information
Authors: Legrand Caroline , Hingray Benoît , Wilhelm Bruno , Ménégoz Martin
Published: April 2023

Abstract. We assess the ability of two typical simulation chains to reproduce, over the last century (1902–2009) and from large-scale atmospheric information only, the temporal variations of river discharges, low flow sequences and flood events, observed at different locations of the Upper Rhône River (URR) catchment, an alpine river straddling France and Switzerland (10,900 km2). The two simulation chains are made up of a downscaling model, either statistical (SCAMP) or dynamical (MAR), and the glacio-hydrological model GSM-SOCONT. Both downscaling models, forced by atmospheric information from the ERA-20C atmospheric reanalysis, provide time series of daily scenarios of precipitation and temperature used as input to the hydrological model. With hydrological regimes ranging from highly glaciated ones in its upper part to mixed ones dominated by snow and rain downstream, the URR catchment is ideal to evaluate the different simulation chains in contrasting and demanding hydro-meteorological configurations where the interplay between weather variables, both in space and time, is determinant. Whatever the river sub-basin considered, the simulated discharges are in good agreement with the reference ones, provided that the weather scenarios are bias-corrected. The observed multi-scale variations of discharges (daily, seasonal and interannual) are well reproduced and the hydrological situations of low frequency (low flow sequences and flood events) are reasonably well reproduced. Bias correction is crucial for both precipitation and temperature and both downscaling models. For the dynamical one, a bias correction is also essential to get realistic daily temperature lapse rates. Uncorrected scenarios lead to irrelevant hydrological simulations, especially for the sub-catchments at high elevation, mainly due to irrelevant snowpack dynamic simulations. The simulations also highlight the difficulty to simulate precipitation dependency to elevation over mountainous areas.
Chemical hydrogel sensors based on the bimorph effect with short response time
Authors: Schreiber Stefan , Steinke Nadja , Gerlach Gerald
Published: April 2023

Abstract. Hydrogel sensors are well suited to measuring the concentration of substances in liquids, and, because the hydrogel is biocompatible, they are ideal for medical use. Hydrogels change their volume in response to stimuli. The larger the hydrogel, the more pronounced the measurement signal. However, a larger volume also leads to slower swelling due to the longer diffusion paths. One method of determining the degree of swelling is to measure the swelling pressure using a piezoresistive pressure sensor. With current approaches, measurement times of several minutes can be achieved. By exploiting the bimorph effect, we were able to reduce the thickness of the hydrogel and, thus, reduce the response time of the entire sensor to less than 1 min. The aim of this paper is now to show how a sensor with short response times can be designed and manufactured and, in particular, how to find a suitable hydrogel composition, how to appropriately structure the hydrogel layer and how a robust adhesion of the hydrogel to the sensor chip can be achieved. As a result, we were able to show that such hydrogel sensors with response times of just a few seconds are possible.
Forward Modelling of SAR Backscatter during Lake Ice Melt Conditions using the Snow Microwave Radiative Transfer (SMRT) Model
Authors: Murfitt Justin , Duguay Claude , Picard Ghislain , Lemmetyinen Juha
Published: April 2023

Abstract. Monitoring of lake ice is important to maintain transportation routes but in recent decades the number of in situ observations have declined. Remote sensing has worked to fill this gap in observations, with active microwave, particularly synthetic aperture radar (SAR), being a crucial technology. However, the impact of wet conditions on radar and how interactions change under these conditions has been largely ignored. It is important to understand these interactions as warming conditions are likely to lead to an increase in the occurrence of slush layers. This study works to address this gap using the snow microwave radiative transfer (SMRT) model to conduct forward modelling experiments of backscatter for Lake Oulujärvi in Finland. Experiments were conducted under dry conditions, under moderate wet conditions, and under saturated conditions. These experiments reflected field observations during the 2020–2021 ice season. Results of the dry snow experiments support the dominance of surface scattering from the ice-water interface. However, conditions where layers of wet snow are introduced show that the primary scattering interface changes depending on the location of the wet layer. The addition of a saturated layer at the ice surface results in the highest backscatter values due to the larger dielectric contrast created between the overlying dry snow and the slush layer. Improving the representation of these conditions in SMRT can also aid in more accurate retrievals of lake ice properties such as roughness, which is key for inversion modelling of other properties such as ice thickness.
Removing Local Nuisances, Arresting Masterless Strangers, and Granting ‘Nights on Request’
Authors: De Koster Margo , Erkul Ayfer
Published: April 2023

This article proposes a comparative study of everyday police controls of vagrants in two Belgian cities – a port city and a capital city – at the end of the nineteenth century, a period that was characterized by heightened mobility and social fear about the so-called ‘masterless poor’. The first section of the article looks at the annual arrest and prosecution rates for vagrancy in Antwerp and Brussels between 1880 and 1910, as well as at the daily instructions from the city authorities and police chiefs to their policemen on how to deal with vagrants and unwanted newcomers. Next, drawing on a selection of archival records of the central police divisions of Antwerp and Brussels from the 1880s, we examine if and how police controls focused on mobile groups when they dealt with vagrancy, and whether they answered the preoccupations of local authorities. In line with the findings of other scholars, we demonstrate that the notion of vagrancy was so elastic that, in both cities, many different groups were arrested and prosecuted for this offence.  Next to foreign and internal migrants, the Antwerp and Brussels police also apprehended local people, born in the city or in the surrounding province, who were not necessarily mobile and often known to them. To explain this, we argue that, in practice, the policing of vagrancy was not only shaped by top-down repression, but also by bottom-up uses of the police by vulnerable individuals in need of shelter.
VARIAÇÕES DE PROCEDIMENTOS NA POSIÇÃO PRONA E INDICAÇÕES DESTE POSICIONAMENTO EM PACIENTES COM COVID-19: REVISÃO DE ESCOPO
Authors: Da Silva Amanda Barbosa , Araújo Jéssica Naiara de Medeiros , Dantas Ana Clara , Carvalho Leandro Melo de , Fernandes Ana Paula Nunes de Lima , Alves Dase Luyza Barbosa de Sousa , Matias Karolayne Cabral , Vitor Allyne Fortes
Published: April 2023

Objetivo: mapear evidências sobre as principais variações de procedimentos na posição prona e as indicações desse posicionamento em pacientes com COVID-19. Método: Scoping Review, realizada em agosto de 2020, através das seguintes fontes de dados: SCOPUS, Web of Science, Science Direct, MEDLINE/PubMed e Google® acadêmico. Dos 82.778 artigos encontrados, 48 compuseram a amostra desta revisão. Resultados: desses artigos, 33,33% (n=16) estavam na fonte de dados Science Direct; para o nível de evidência, o nível 4 foi observado em 39,58% (n=19); o grau de recomendação C apresentou-se em 41,66% (n=20); e 77,08% (n=37) foram publicados no período entre 2016 e 2020. Sobre o local de publicação, 31,25% (n=15) foram publicados na América do Norte e 81,25% (n=39) dos estudos foram publicados em inglês. Dentre as principais variações de procedimentos na posição prona, as adaptações para realização da reanimação cardiopulmonar foi a mais citada (37,50%; n=18). Recomenda-se que a posição prona seja realizada em pacientes com síndrome do desconforto respiratório agudo de moderada a grave. Conclusões: os achados permitiram o conhecimento sobre os principais procedimentos, e suas observações, realizados em pacientes em posição prona, servindo de subsídio para o manejo correto desses pacientes, contribuindo, assim, para o avanço da ciência da saúde.
FERRAMENTAS MENSURADORAS DO RISCO CARDIOVASCULAR EM PESSOAS VIVENDO COM HIV: REVISÃO DE ESCOPO
Authors: Vasconcelos Mayara Nascimento de , Castro Lima Alana Eufrásio de , Pereira Vidal Emilly Alves , Cavalcante Sousa Nayara Wennya , Magalhães Moreira Thereza Maria , Duarte Pereira Maria Lúcia
Published: April 2023

Objetivo: mapear evidências científicas de ferramentas mensuradoras do risco cardiovascular que são utilizadas em pessoas vivendo com vírus da imunodeficiência humana. Método: revisão de escopo, seguindo as orientações do Instituto Joanna Briggs, utilizando dois portais de dados para realizar o levantamento dos estudos. O protocolo foi reportado conforme recomendações do checklist PRISMA-ScR (PRISMA extension for Scoping Review), sendo registrado na Open Science Framework sob o DOI 10.17605/OSF.IO/Z3CMQ (https://osf.io/z3cmq/). Resultados: foram identificadas cinco ferramentas de mensuração do Risco Cardiovascular: Framingham Cardiovascular Risk Score (FRS), Prospective Cardiovascular Munster (PROCAM), Systemic Coronary Risk Evaluation (SCORE), Progetto CUORE, Data Collection on Adverse Effects of Anti-HIV Drugs (DAD) risk equations (D:A:D). Dentre essas ferramentas, apenas o escore D:A:D foi construído de forma direcionada especificamente às pessoas vivendo com o vírus da imunodeficiência humana, sendo as demais direcionadas para a população geral.Conclusão: ressalta-se a relevância, para a saúde pública brasileira, de se construir instrumentos específicos para mensuração do risco cardiovascular, em pessoas vivendo com o vírus da imunodeficiência humana, adotando técnicas estatísticas mais robustas.
Ciencia ficción, figuras de exclusión e xénero na cultura galega
Authors: Garrido González Ana , Moszczyńska-Dürst Katarzyna
Published: April 2023

Ciencia ficción, figuras de exclusión e xénero na cultura galega
Antes de soñármonos eléctricos. Ficción científica e distopía no final do franquismo
Authors: Regueira Mario
Published: April 2023

A relación da cultura galega con ámbitos como a ficción científica ten unha serie de características específicas. A historia literaria galega considera a publicación de Soños eléctricos de Ramón Caride en 1992 a primeira achega literaria a este subxénero; porén, existe unha serie de precedentes próximos á ficción científica entre o final do franquismo e a aparición desta obra emblemática. Neste artigo analízase a pegada desas propostas, previas á parte máis importante do desenvolvemento editorial galego e relativamente independentes das súas principais liñas de acción. Detéremonos especialmente na súa calidade de obras aparecidas nunha marxe cultural e histórica, polo feito de seren anteriores ou antagonistas da “cultura da normalización”. Asimesmo, na idea de que as especulacións futurista teñen sempre unha dimensión política implícita ou explícita, este artigo analiza cómo esta dimensión aparece nos casos de estudo. Para isto, centrarémonos na súa relación coa ciencia e a tecnoloxía, en como presentan a organización social, na posibilidade dunha lectura poscolonial e, máis específicamente, nas representacións de xénero e da sexualidade, aplicando o enfoque que ofrecen os estudos queer para identificar alternativas ou persistencias da cultura heteronormativa.
Relação entre os dados epidemiológicos da Covid-19 e as políticas de imunização e contenção no Nordeste do Brasil.
Authors:   , Cristina Melo da Silva Paloma
Published: April 2023

A pandemia do Coronavírus causou impactos incalculáveis, chegando a 2,5 milhões de mortes e danos socioeconômico de alto nível, tornando-se um marco histórico mundial. Estabeleceu-se como objetivo geral da pesquisa relacionar os dados epidemiológicos da Covid-19 com as ações governamentais dos estados do Nordeste brasileiro. A perspectiva teórica é a nível das ações adotadas pelos governos estaduais no Nordeste do Brasil por meio das Políticas Públicas de enfrentamento à Covid-19. Este tema é de ampla relevância pois trata de pautas importantes que envolvem informações factuais a fim de orientar os governantes a agirem de maneira mais rápida e segura, e ainda propõe analisar ações, estas designadas em forma de Políticas Públicas pertinentes ao âmbito estadual, ou seja, tem aderência ao tema da Saúde Pública e à qualidade de vida do cidadão. Este é um estudo de natureza quantitativa, do tipo descritiva com o uso da técnica de levantamento de dados secundários e análise documental, esse desenho metodológico se deu para atender ao objetivo da pesquisa, com intuito de analisar e apresentar empiricamente dados epidemiológicos, as ações que foram implementadas e suas influências nos (9) estados da região Nordeste, e assim, foi possível observar que as (100) medidas implementadas no Nordeste, auxiliaram para conter a disseminação, entretanto, só após a Política de Vacinação contra à Covid-19 foi possível chegarmos ao controle no número de infectados e principalmente, de óbitos, quando em momentos de pico pandêmico o estado da Bahia registrou o maior número de casos de covid-19 (380.294 casos), enquanto o Ceará registra o maior número de dados de óbitos causados pela Covid-19 (9.443), no período de março à outubro de 2020, ou seja, a agilidade em aplicar medidas radicais junto a imunização comprovou a redução no número de casos no Nordeste e nos demais estados.
Moule chinoise (Sinanodonta woodiana Lea 1834) arrive dans le Massif central
Authors: Duboc Pascal
Published: April 2023

La Moule chinoise (Sinanodonta woodiana Lea 1834) fournit sa première observation régionale dans le Massif central. Cette espèce exogène est potentiellement invasive.
Découverte de Sphagnum affine Ren. & Card. dans le Limousin – origine et originalité de la population
Authors: Charissou Isabelle , Hugonnot Vincent
Published: April 2023

Sphagnum affine a été observée pour la première fois sur le plateau de Millevaches (Corrèze). Son écologie et ses effectifs sont présentés ici, ainsi qu’une comparaison avec les autres populations connues en France. L’origine de cette population est brièvement discutée.
EFFECT OF MOLECULAR ENVIRONMENT ON PROTEIN RUBBER PROPERTIES
Authors: Chauhan Natasha , Barone Justin R.
Published: April 2023

Many natural organisms use “protein rubbers” to store and release an imposed strain energy with high efficiency to make motion easier. Protein rubbers exist in a complicated environment surrounded by water and other molecules such as sugars, implying that amino acid composition and its environment are important in protein rubber behavior. Gelatin, the hydrolysis product of animal collagen, is hydrated or “plasticized” with water, ethylene glycol, glycerol, corn syrup, and aqueous solutions of sorbitol, glucose, and fructose. The rubber formed is “dry”, that is, is not fully immersed in liquid, and has the appearance and feel of a soft rubber band. The mechanical and thermodynamic behavior of each rubber is characterized with low strain dynamic and high strain tensile experiments with good agreement between the two. Plasticized gelatin rubbers are incompressible and follow the neo-Hookean model for rubber elasticity up to moderate extension ratios. Higher molecular weight polyols with more hydrogen bond donors and acceptors create gelatin networks with lower crosslink density. Ethylene glycol–, glycerol-, sorbitol syrup–, and fructose syrup–plasticized gelatin rubbers have similar molecular relaxation mechanisms and are the most efficient rubbers when probed in the rubbery plateau region prior to approaching the glass transition. The other plasticizers have different molecular relaxation mechanisms that detract from the efficiency of energy storage and return that is not related to network formation but perhaps the individual solvation ability of each plasticizer.
Heartwood Extract of Neolamarckia Cadamba Ameliorates Oxidative Stress Linked Type II Diabetes in Wistar Albino Rats
Authors: Bhushan Mishra Shanti , Maurya Mukul , Srivastava Vineet
Published: April 2023

The Neolamarcia cadamba plant has traditionally been claimed for the treatment of a variety of metabolic disorders, including diabetes. Many scientific studies have also proved its effectiveness against various diseases due to the presence of several chemical constituents viz. Quinovic Acid, Cadamabine, Cadambagenic Acid, Cadamine, Beta-Sitosterol, Chlorogenic Acid, etc. Therefore, in this study the effect of 50% ethanolic extract (NCEE) from the heartwood of the plant was evaluated for its potential antidiabetic, hypolipidemic and antioxidant effects in Streptozotocin (STZ) and high fat diet (HFD) induced diabetic rats. Preliminary phytochemical screening of NCEE revealed the presence of phenolic compounds, flavonoids, steroids and alkaloids. NCEE (200 and 400mg/kg body weight) was administered orally to diabetic rats, once daily for 3 weeks. Blood glucose levels, various biochemical parameters, antioxidant enzyme levels and histopathological investigation were performed in the diabetic control group and the extract treated groups. Plant extracts have a dose-dependent antidiabetic effect by normalizing the levels of antioxidant enzyme biomarkers and hematological abnormalities and ameliorating histopathological changes compared to the diabetic control group. The observations confirmed that the 50% ethanolic extract of heartwood of Neolamarckia cadamba (Roxb.) Bosser exhibits anti-diabetic, hypolipidemic effect along with mitigation of oxidative stress.
Amiodarone’s effect on the Pharmacokinetics of Glibenclamide in Healthy and Diabetic Rats
Authors: Pandit Khedkar Jyotsna , Kanti Das Sreemoy , Suresh Salunke Prashant , Poddar Sandeep
Published: April 2023

Background: The purpose of this study is to determine how amiodarone, an antiarrhythmic medication, affects Glibenclamide's hypoglycemic activity in normal and diabetic rats when administered in multiple doses over seven days. Methods: The researchers intended to explore how glibenclamide and amiodarone pharmacologically interact in normal and diabetic rats. These tests were performed on the same group of rats after the provided medications Glibenclamide 1.03 mg/kg body weight and Amiodarone 50 mg/kg body weight had been entirely eliminated, i.e. after the drugs had been totally eliminated. The drugs were administered orally. After taking blood samples from the tail vein at predetermined intervals, the glucose levels were estimated using the GOD/POD technique. Results:The findings showed that numerous doses of amiodarone, an antiarrhythmic medication, affected the hypoglycaemic action of Glibenclamide in normal and diabetic rats when provided alone and in combination with Glibenclamide. This might be because amiodarone and Glibenclamide have a pharmacokinetic interaction. Conclusion: Preliminary research suggests that the combination has a pharmacokinetic interaction in diabetic patients with arrhythmia. As a result, blood glucose levels needed to be closely monitored.
Application of Box-Behnken Experimental Design in Process Parameter Optimization for Production of Berberine HCl loaded Chitosan Coated Sodium Alginate Nanoparticles
Authors: Kumar Vinod , Kumar Prashant , Sharma Saurabh
Published: April 2023

Psoriasis is the most common chronic autoimmune disease. The pathophysiology, genetics, comorbidities, and biologic therapies of plaque psoriasis have seen the most rapid advances. Only a tiny percentage of the supplied dose reaches the target site in most situations (traditional dosage forms), while the balance is distributed throughout the body according to its physicochemical and biochemical properties. The current worker used nanotechnology to carry out study on the formulation and evaluation of nanoparticulate Berberine HCl loaded Chitosan coated sodium alginate nanoparticles. The Berberine HCl Nanoparticles were optimised using the Box-Behnken design. Particle size (68.82-275.78nm), zeta potential ((10.90)– (47.1 mv), percentage yield (80.75 percent - 96.21percent), percentage drug entrapment (50.95 -77.28percent), and percentage release in pH 7.4 phosphate buffer (60.848 - 95.869percent) were all found to be positive with Berberine HCl nanoparticles. Nanoparticles were found to be spherical in shape with rough surfaces, according to surface morphology (SEM). In a pH 7.4 phosphate buffer, an in-vitro drug release investigation on an optimised batch of Berberine HCl nanoparticles (BE-OPT) revealed 96.242percent (12 h) release. The release kinetic investigation with the optimised batch of Berberine HCl nanoparticles (BE-OPT) demonstrated that Higuchi's release kinetic model was followed. The chosen (optimised) nanoparticles were sealed in amber-coloured bottles with cotton plugs and caps. All were kept for six months at 40±2°C/75±5% RH and examined for their physical appearance and drug content at certain intervals.
Chrysanthemum cinerariifolium (Trev.) Vis leaves extract reduces the level of Macrophages, Interleukin-17, and Keratinization in Oral squamous cell carcinoma rat model
Authors: Listiyana Anik , Aprinda Kristanti Risma , Dharmayanti Nadya , Milladina Hidayatulloh Rizkia , Baraja‬‬‬‬‬‬‬‬‬‬‬‬ Sakinah
Published: April 2023

Chrysanthemum cinerariifolium (Trev.) Vis. leaves have potential anticancer activity and are expected to inhibit oral squamous cell carcinoma (OSCC) progression. The present study aimed to determine the effect of ethanol extract of C. cinerariifolium leaves on the number of macrophages, IL-17 levels, and degree of keratinization in the OSCC rat model. Thirty male Sprague Dawley rats (weighing 80-160g, 2-3 months old) were randomly divided into five groups (n=6): (1) negative control (healthy rat, untreated); (2) positive control (OSCC rat); (3-5) dose 1, 2 and 3 (OSCC rat received 50, 100 and 200mg/kg BW of C. cinerariifolium leaves, respectively). The tongues of the rats were prepared for Hematoxylin-Eosin (HE) staining and immunohistochemistry. The number of macrophages was determined under a light microscope with 400x magnification. The level of IL-17 was examined using an ELISA assay. The degree of keratinization was calculated using the ImageJ software. All doses of C. cinerariifolium leaves extract could reduce the number of macrophages in OSCC rats. The levels of IL-17 in OSCC rats were decreased after being treated with 100 and 200mg/kg BW of C. cinerariifolium leaves extract. The high dose of C. cinerariifolium leaves extract (200mg/kg BW) reduced the degree of keratinization in the OSCC rat model. The study revealed that C. cinerariifolium leaves extract could inhibit the progression of OSCC by reducing macrophage, IL-17 and keratinization.
Potential Ethanol Extract of Rhinachantus nasutus (L.) Kurz Stem Bark as Antioxidant and Inhibitor of Dipeptidyl Peptidase IV (DPP IV) Activity
Authors: Irawan Candra , Elya Berna , Hanafi Muhammad , Chany Saputri Fadlina
Published: April 2023

Rhinachantus nasutus (L.) Kurz is a plant that has long been used by people in Southeast Asia, India, and China as traditional medicine. R. nasutus plant preparations have been used in traditional medicine to treat diabetes. This study aims to reveal: the content of a group of secondary metabolite compounds in the extract of the stem bark R. nasutus; The extract's potential as an antioxidant with 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical inhibition parameters and ferric-reducing power, and it's potential as an antidiabetic by inhibiting dipeptidyl peptidase IV (DPP IV) activity. Phytochemical screening results on the ethanol extract of the stem bark of R. nasutus found the presence of steroid glycosides, phenolic, alkaloids, and tannins. The antioxidant activity test using the DPPH and ferric reducing antioxidant power (FRAP) methods gave an IC50 valuesof 90.668±0.084 mg/L and 8.91±0.023mg/L, respectively. In addition, the ethanol extract of the stem bark can inhibit the activity of DPP IV with a % inhibition of 52.19±1.667. From this study, we can conclude that the ethanol extract of the stem bark R. nasutus can potentially be a source of antioxidants and antidiabetes.
Spectrophotometric Simultaneous Estimation of Raloxifene and Naringin by Vierordt’s Method
Authors: Alhalmi Abdulsalam , Amin Saima , Kohli Kanchan
Published: April 2023

A new Vierordt’s Method or simultaneous equation method was developed and validated for the simultaneous estimation of raloxifene hydrochloride (RAL) and naringin (NAR) in their pure binary mixture and nanoformulation dosage form. The method was based on measuring absorbance at two wavelengths 289nm and 284nm (λmax of RAL and NAR) respectively in methanol. Absorptivities of RAL at 289 and 284nm were (689.5 and 683.13), and those of NAR was (282.45 and 316.75). The % recovery values for accuracy studies were found to be in the range (102% and 96.45%) for RAL and NAR, respectively. The % recovery values for precision studies were found to be in the range (Intraday precision; 102.78% and 96.13%), ( Interday precision; 102.58% and 96.02%) for RAL and NAR, respectively were found to be satisfactory. The linearity of the calibration plots was confirmed by the high value of the correlation coefficients (R2 = 0.9994 for RAL and 0.995 for NAR). The limit of detection and limit of quantification were theoretically calculated which were found to be (0.57µg/ml and 0.613µg/ml) and (4.25µg/ml and 4.55µg/ml) for RAL and NAR, respectively. Robustness was also carried out and %RSD was found to be less than 2.0%. The proposed method was successfully used to estimate RAL and NAR in the pure binary mixture and their nanoformulation dosage forms.
Oxidative Stress and Renal Function in Pediatric Patients with Beta Thalassemia Major (β-TM) Receiving Deferiprone and Deferasirox:
A Cross-Sectional, Single Center Study
Authors: Budi Wijaya Andreas , Marhaeni Wulandewi , Triawanti Triawanti , Riza Devi Wivina , Saputra Maulana , Rahman Galih
Published: April 2023

Oxidative stress in β-TM (beta-thalassemia major) patients is associated with increased of malondialdehyde (MDA) level and also decreased of superoxide dismutase (SOD) level. Deferiprone and deferasirox, which are used for the treatment of iron overload, exhibit antioxidant potential. However, various clinical studies have shown an increase in creatinine levels in pediatric patients receiving oral iron chelator. There was limited study assessed oxidative stress and impact of β-TM on the renal function, especially in children that growing up with β-TM and receiving iron chelator. Therefore, the aim of the study is to investigate renal function and oxidative stress between β-TM patients at Ulin Hospital Banjarmasin who received deferasirox and deferiprone. Ninety β-TM patients (aged 2-≤18 years) with regular iron chelators (deferiprone or deferasirox) use at Ulin Hospital between October-December 2020, were included in this cross-sectional study. Laboratory examinations included complete peripheral blood count, serum ferritin, urea, creatinine, MDA and SOD. Statistical analysis was used to compare all parameters between two groups.There was no significant difference in the levels of MDA (p= 0.663), SOD (p= 0.102), urea (p= 0.597), creatinine (p= 0.067) and glomerular filtration rate (p= 0.792) between the two groups. In this study, 9 patients had decreased GFR, of which 3 patients (33.3%) were taking DFX. Thus, 13.6% of DFX users (3 of 22 patients) and 8.8% of DFP users (6 of 68 patients) had decreased renal function. In general, the mean glomerular filtration rate (GFR) of the patients in this study ranged from 126.74± 32.71ml/kg/min/1.73m2. For conclusion, deferiprone and deferasirox had no significant difference in terms of protection against oxidative stress. However, the decline in renal function occurred slightly higher in deferasirox users. Early recognition will be an important key to prevent renal complication