bluuebunny/crossref_metadata_2025 huggingface dataset:
An Educational Module to Teach Interprofessional Learner Feedback Skills for Trauma Simulation Events
Authors: Dickinson Karen J. , Kimbrough Mary Katherine , Young Amanda , Goddard Clayton , Urban Kelly , Kalkwarf Kyle J. , Bhavaraju Avi , Margolick Joseph
Published: April 2022

Background

Peer feedback, or feedback given by a learner to another learner, is an important active learning strategy. Hierarchy and stereotypes may affect interprofessional (IP) learner‐to‐learner feedback. The aim was to assess the efficacy of an educational module for IP learners in delivering effective feedback during trauma simulations.

Methods

Multiple simulation events designed to improve teamwork and leadership skills during trauma simulations included IP learners (residents and nurses). Participants completed a pre‐course educational module on IP peer feedback. The Trauma Team Competence Assessment‐24 tool structured feedback. Learners completed pre/post‐assessments utilizing IP Collaborative Competencies Attainment Survey (ICCAS).

Results

Twenty‐five learners participated in the trauma simulations (13 general surgery and 5 emergency residents, 3 medical students, 4 nurses). The majority of learners had either not received any previous training in how to effectively deliver peer feedback (40%) or had engaged in self‐directed learning only (24%). Most learners (64%) had delivered peer feedback less than ten times. Learner knowledge and confidence in delivering feedback to fellow IP learners improved after simulations. All learners felt the feedback received was useful to their daily practice (68% agree, 32% strongly agree). All participants agreed that the simulation achieved each of the ICCAS competencies.

Conclusions

Formal education on IP peer feedback is rare. This pilot work demonstrates educational modules with a foundation in validated tools can be effective in improving learner knowledge and confidence in the process. Engaging in IP peer feedback may also serve to flatten hierarchies that can challenge effective interprofessional teamwork.
Development and evaluation of machine learning models based on X-ray radiomics for the classification and differentiation of malignant and benign bone tumors
Authors: von Schacky Claudio E. , Wilhelm Nikolas J. , Schäfer Valerie S. , Leonhardt Yannik , Jung Matthias , Jungmann Pia M. , Russe Maximilian F. , Foreman Sarah C. , Gassert Felix G. , Gassert Florian T. , Schwaiger Benedikt J. , Mogler Carolin , Knebel Carolin , von Eisenhart-Rothe Ruediger , Makowski Marcus R. , Woertler Klaus , Burgkart Rainer , Gersing Alexandra S.
Published: April 2022

Objectives

To develop and validate machine learning models to distinguish between benign and malignant bone lesions and compare the performance to radiologists.

Methods

In 880 patients (age 33.1 ± 19.4 years, 395 women) diagnosed with malignant (n = 213, 24.2%) or benign (n = 667, 75.8%) primary bone tumors, preoperative radiographs were obtained, and the diagnosis was established using histopathology. Data was split 70%/15%/15% for training, validation, and internal testing. Additionally, 96 patients from another institution were obtained for external testing. Machine learning models were developed and validated using radiomic features and demographic information. The performance of each model was evaluated on the test sets for accuracy, area under the curve (AUC) from receiver operating characteristics, sensitivity, and specificity. For comparison, the external test set was evaluated by two radiology residents and two radiologists who specialized in musculoskeletal tumor imaging.

Results

The best machine learning model was based on an artificial neural network (ANN) combining both radiomic and demographic information achieving 80% and 75% accuracy at 75% and 90% sensitivity with 0.79 and 0.90 AUC on the internal and external test set, respectively. In comparison, the radiology residents achieved 71% and 65% accuracy at 61% and 35% sensitivity while the radiologists specialized in musculoskeletal tumor imaging achieved an 84% and 83% accuracy at 90% and 81% sensitivity, respectively.

Conclusions

An ANN combining radiomic features and demographic information showed the best performance in distinguishing between benign and malignant bone lesions. The model showed lower accuracy compared to specialized radiologists, while accuracy was higher or similar compared to residents.

Key Points

• The developed machine learning model could differentiate benign from malignant bone tumors using radiography with an AUC of 0.90 on the external test set.

• Machine learning models that used radiomic features or demographic information alone performed worse than those that used both radiomic features and demographic information as input, highlighting the importance of building comprehensive machine learning models.

• An artificial neural network that combined both radiomic and demographic information achieved the best performance and its performance was compared to radiology readers on an external test set.
Fine scale reconstruction (VIC#) by implementing additional constraints and coarse-grid approximation into VIC+
Authors: Jeon Young Jin , Müller Markus , Michaelis Dirk
Published: April 2022

This study proposes a method that complements Vortex-In-Cell plus (VIC+) (Schneiders and Scarano, Exp Fluids 57:139, 2016), a data assimilation technique that reconstructs a dense flow field from sparse particle tracks. Here, the focus is on the treatment of boundary conditions. In the VIC+ method, the choice of boundary conditions significantly affects a large part of the inner domain through their role as Dirichlet boundary conditions of the Poisson equations. By nature, there are particle tracks on one side of the boundaries, and often, due to experimental limitations, the track density is low, just close to the boundaries. This lack of data near the boundaries leads to a poor iterative update of the boundary condition for VIC+. Overall, the VIC+ method tends to be sensitive about the specific choice of the initial conditions, including the inner domain and the boundaries. Without prior flow information, a large padded volume has been proposed to achieve stable and reliable convergence, at the cost of a large number of additional unknowns that need to be optimized. The present method pursues the following concepts to resolve the above issues: use of the smallest possible padding size, reconstruction starting with “all zero” initial conditions, and progressive correction of the boundary conditions by considering the continuity law and the Navier–Stokes equation. These physical laws are incorporated as additional terms in the cost function, which so far only contained the disparity between PTV measurements and the VIC+ reconstruction. Here, the Navier–Stokes equation allows an instantaneous pressure field to be optimized simultaneously with the velocity and acceleration fields. Moreover, the scale parameters in VIC+ are redefined to be directly computed from PTV measurement instead of using the initial condition, and new scaling factors for the additional cost function terms are introduced. A coarse-grid approximation is employed in order to both improve reconstruction stability and save computation time. It provides a subsequent finer-grid with its low-resolution result as an initial condition while the interrogation volume slightly shrinks. A numerical assessment is conducted using synthetic PTV data generated from the direct numerical simulation data of forced isotropic turbulence from the Johns Hopkins Turbulence Database. Improved reconstructions, especially near the volume boundary, are achieved while the virtues of VIC+ are preserved. As an experimental assessment, the existing data from a time-resolved water jet is processed. Two reconstruction domains with different sizes are considered to compare the boundary of the smaller domain with the inside of the larger one. Visible enhancements near the boundary of the smaller domain are observed for this new approach in time-varying flow fields despite the limited input from PTV data.

Graphical abstract
Linkage between cross-equatorial potential vorticity flux and surface air temperature over the mid–high latitudes of Eurasia during boreal spring
Authors: Sheng Chen , Wu Guoxiong , He Bian , Liu Yimin , Ma Tingting
Published: April 2022

The source of potential vorticity (PV) for the global domain is located at the Earth’s surface. PV in one hemisphere can exchange with the other through cross-equatorial PV flux (CEPVF). This study investigates the features of the climatic mean CEPVF, the connection in interannual CEPVF with the surface thermal characteristics, and the associated mechanism. Results indicate that the process of positive (negative) PV carried by a northerly (southerly) wind leads to the climatologically overwhelming negative CEPVF over almost the entire equatorial cross-section, while the change of the zonal circulation over the equator is predominately responsible for CEPVF variation. By introducing the concept of “PV circulation” (PVC), it is demonstrated that the interannual CEPVF over the equator is closely linked to the notable uniform anomalies of spring cold surface air temperature (SAT) over the mid–high latitudes of Eurasia by virtue of the PVC, the PV-θ mechanism, and the surface positive feedback. Further analysis reveals that equatorial sea surface temperature (SST) forcing, such as the El Niño–Southern Oscillation and tropical South Atlantic uniform SST, can directly drive anomalous CEPVF by changing the zonal circulation over the equator, thereby influencing SAT in the Northern Hemisphere. All results indicate that the equilibrium linkage between CEPVF and extratropical SAT is mainly a manifestation of the response of extratropical SAT to tropical forcing by virtue of PVC, and that the perspective of PVC can provide a reasonably direct and simple connection of the circulation and climate between the tropics and the mid–high latitudes.
Precision of the Wilson corrective osteotomy of the first metacarpal base using specific planning and instruments for treatment of basal thumb arthritis
Authors: Kriechling Philipp , Reissner Lisa , Zindel Christoph , Andronic Octavian , Schweizer Andreas
Published: April 2022

Introduction

Arthritis of the basal thumb is a relatively common condition also affecting younger patients. Wilson et al. described a 20°–30° closing wedge osteotomy of the first metacarpal bone to unload the trapeziometacarpal joint. It was the purpose of this study to analyze the clinical and radiographic outcome of patients who underwent proximal extension osteotomy of the first metacarpal bone using patient-specific planning and instruments (PSI).

Methods

All patients who underwent proximal metacarpal osteotomy for basal thumb arthritis at our tertiary referral center were retrospectively included. The patients underwent preoperative planning using computed tomography and 3D segmentation to build patient-specific guides and instruments for the operative treatment. Stable fixation of the osteotomy was achieved by internal plating. The inclusion criterion was a minimum follow-up of 1 year with clinical examination, including the Michigan Hand Outcomes Questionnaire (MHQ), and computed tomography to validate the correction. Complications and reinterventions were recorded.

Results

A total of eight Wilson osteotomies in six patients could be included at a mean follow-up duration of 33±16 months (range, 12 to 55 months). The patients were 49±8 years (range, 36 to 58 years) at the surgery and 88% were female. The postoperative MHQ for general hand function was 77±8 (range, 45 to 100) and the MHQ for satisfaction was 77±28 (range, 17 to 100). The working status was unchanged in 7/8 hands (6/7 patients). Radiographic analysis revealed successful correction in all cases with unchanged Eaton–Littler stage in 7/8 hands. No complications were recorded.

Conclusion

The combined extending and ulnar adducting osteotomy using patient-specific guides and instrumentation provides an accurate treatment for early-stage thumb arthritis.

Level of evidence

Type IV—retrospective, therapeutic study.
Surgical management of endocervical and decidual polyps during pregnancy: systematic review and meta-analysis
Authors: Riemma Gaetano , Della Corte Luigi , Vitale Salvatore Giovanni , Cianci Stefano , La Verde Marco , Giampaolino Pierluigi , Cobellis Luigi , De Franciscis Pasquale
Published: April 2022

Purpose

To evaluate the impact of endocervical and decidual polypectomy on obstetrical outcomes of pregnant women.

Methods

MEDLINE, Scopus, ClinicalTrials.gov, Scielo, EMBASE, Cochrane Library at the CENTRAL Register of Controlled Trials, and LILACS were searched from inception to April 2021. No language or geographical restrictions were applied. Inclusion criteria regarded observational studies concerning pregnant women with a cervical lesion who underwent cervical polypectomy. Co-primary outcomes were incidence of late pregnancy loss and preterm birth in women with endocervical or decidual polypectomy as well as polypectomy versus expectant management. Random effect meta-analyses to calculate risk ratio (RR) with 95% confidence interval (CI) were performed. Quality assessment of included papers was performed using Newcastle–Ottawa Scale criteria.

Results

Three studies, with data provided for 3097 women, were included in quantitative analysis, with comparisons between endocervical and decidual polyps extracted from two studies and 156 patients. After a first trimester endocervical or decidual polypectomy, no significant differences were found for late pregnancy losses (RR 0.29 [95% CI 0.05, 1.80], I2 = 11%). Risk for preterm birth was significantly higher for decidual polyps’ removal (RR 6.13 [95% CI 2.57, 14.59], I2 = 0%). One paper compared cervical polypectomy vs expectant management, with increased incidence of late pregnancy loss (4/142 vs 5/2799; p < 0.001) and preterm birth (19/142 vs 115/2799; p < 0.001) in women subjected to polypectomy.

Conclusions

Evidence regarding the removal of cervical polyps in pregnancy is extremely limited. However, the removal of either decidual or endocervical polyps seems associated with increased risk of pregnancy loss and preterm birth, with increased preterm birth risk following endocervical rather than decidual polypectomy.
Topographic, tomographic, and corneal wavefront asymmetry in keratoconus: towards an eye asymmetry index EASIX
Authors: Mehlan Juliane , Steinberg Johannes , Druchkiv Vasyl , Katz Toam , Linke Stephan Johannes
Published: April 2022

Purpose

The study aims to explore the intereye asymmetry in normal and keratoconic individuals and to evaluate the discriminant power of single and combined asymmetry parameters.

Methods

This is a retrospective designed study including 414 patients who had Pentacam Scheimpflug topographic and tomographic imaging in both eyes: 124 subjects with bilateral normal corneas evaluated for refractive surgery and 290 with keratoconus. All elevation-, pachymetric-, and volumetric-based data (56 parameters) were electronically retrieved and analyzed. Intereye asymmetry was determined by subtracting the lowest value from the highest value for each variable. The degree of asymmetry between each subject’s eyes was calculated with intraclass correlation coefficients for all the parameters. Receiver operating characteristic curve was used to determine predictive accuracy and to identify optimal cutoffs of these values and combinations thereof.

Results

In the normal/keratoconus subjects the median intereye asymmetries were 0.30/3.45 for K2 (flat) meridian, 0.03/0.25 for BFS front, 1.00/15.00 for elevation back BFS apex, and 7.00/29.00 for pachy min.

Conclusions

In addition to Rabinowitz’s Kmax intereye asymmetry we propose pachymetric, elevation-based, and high-order corneal wavefront intereye asymmetry parameters to improve the diagnostic armamentarium of keratoconus.
Single nephron glomerular filtration rate measured by linescan multiphoton microscopy compared to conventional micropuncture
Authors: Costanzo Vincenzo , D’Apolito Luciano , Sardella Donato , Iervolino Anna , La Manna Gaetano , Capasso Giovambattista , Frische Sebastian , Trepiccione Francesco
Published: April 2022

Renal micropuncture, which requires the direct access to the renal tubules, has for long time been the technique of choice to measure the single nephron glomerular filtration rate (SNGFR) in animal models. This approach is challenging by virtue of complex animal preparation and numerous technically difficult steps. The introduction of intravital multiphoton microscopy (MPM) offers another approach to the measure of the SNGFR by mean of the high laser-tissue penetration and the optical sectioning capacity. Previous MPM studies measuring SNGFR in vivo relied on fast full-frame acquisition during the filtration process obtainable with high performance resonant scanners. In this study, we describe an innovative linescan–based MPM method. The new method can discriminate SNGFR variations both in conditions of low and high glomerular filtration, and shows results comparable to conventional micropuncture both for rats and mice. Moreover, this novel approach has improved spatial and time resolution and is faster than previous methods, thus enabling the investigation of SNGFR from more tubules and improving options for data-analysis.
Linking crown structure with tree ring pattern: methodological considerations and proof of concept
Authors: Pretzsch Hans , Ahmed Shamim , Jacobs Martin , Schmied Gerhard , Hilmers Torben
Published: April 2022

Key message

Structural characteristics of tree crowns obtained by TLidar scanning can be used for estimating the course of the stem diameter growth in the past.

To improve human well-being through sustainable management of ecosystems, particular attention is given to the structures, functions, and services of forest trees and stands. The classical timber provision has become only one of many other forest ecosystem services. At the same time, the methods of ecosystem observation, analysis, and modelling have enormously improved. Here, we fathomed the information potential of the tree crown structure. Our overarching hypothesis was that the crown structure reflects essential characteristics of the tree ring pattern. The empirical part of this study was based on sample trees from the combined spacing-thinning trial in Norway spruce (Picea abies [L.] Karst.) Fürstenfeldbruck 612 in Southern Germany. First, we showed that the external characteristics of tree crowns and the internal stem structure are functionally linked. Second, we derived metrics for the tree ring pattern and crown shape, and found especially close relationships between the level and bending of the growth curve and the size and stereometric shape of the crown. Third, we investigated how the derived statistical relationships between tree ring pattern and crown structure can be applied to derive the course of tree growth from the crown structure. We showed how measures such as size and variability of the crown could be used to estimate the course of diameter growth. Finally, we showed that the revealed link could be used to assess past and future growth and life expectancy of trees. These findings can be used to monitor the stress defence potential, resistance, and resilience of trees.
Optimizing contract allocation for risky conservation tenders
Authors: Olita Harriet Toto , Iftekhar Md. Sayed , Schilizzi Steven G. M.
Published: April 2022

In the face of a shrinking budget for environmental activities, conservation agencies must design and implement agri-environmental policies that cost-effectively meet the environmental objectives. However, designing such programs is often challenging due to different uncertainties. For example, landholders may be exposed to risks when carrying out conservation projects. To minimise the negative impact of unexpected losses, landholders may require additional financial incentives as compensation for undertaking “risky” conservation projects. In such situations, the conservation agency risks over-spending public funds because of prohibitively high opportunity costs from landholders or failing to meet the environmental target. We used analytical and simulation approaches to explore optimal budget allocation in a target-constrained conservation tender. We also compared the performance of the tender with and without own-cost uncertainty. Results showed that as landholders’ own-cost uncertainty rises, the conservation agency is forced to allocate more funding to secure the same level of the environmental target. We found that the optimal funding level is sensitive to landholders’ competition uncertainty and the magnitude of expected losses.
Temporal and spatial variability of cross-fault groundwater-level differences: the impact of fault-induced permeability reduction, precipitation and evapotranspiration
Authors: Lapperre Rimbaud E. , Bense Victor F. , Kasse Cornelis , van Balen Ronald T.
Published: April 2022

Faults in the Roer Valley Rift System (Netherlands, Belgium, and Germany) act as barriers to lateral groundwater flow in unconsolidated sedimentary aquifers. This causes a cross-fault groundwater-level step of up to several metres. Using a dataset obtained through 5 years of high-frequency monitoring, the effect of fault-zone permeability, precipitation and evapotranspiration on cross-fault groundwater-level steps is studied at two sites situated across the Peel Boundary Fault. Hydraulic conductivity values at the fault are 1–3 orders of magnitude lower than that of similar lithologies away from the fault, indicating that fault displacement has a significant impact on groundwater flow. The influence of precipitation and evapotranspiration on fault-zone hydrology is inferred from water-table fluctuations over short distances across the fault. On the foot wall, the water table is nearer to the surface and displays a shorter level range with a spiky temporal variability. On the hanging wall, a deeper water table is sloping away from the fault and shows a wider level range with a smoother temporal variability. The observed groundwater level fluctuations are attributed mainly to precipitation and evapotranspiration dynamics. At a larger spatial scale, the 5-year-average cross-fault groundwater-level steps at the two sites are 1.59 and 1.39 m. At a smaller scale, the cross-fault groundwater-level step is much less because of the rising water table towards the fault on the hanging wall. At the smallest scale, just across the fault zone, the groundwater level step is around 0.2 m, indicating that the fault is semi-impermeable.
User experience in safety–critical domains: a survey on motivational orientations and psychological need satisfaction in acute care
Authors: Hohm Anna , Happel Oliver , Hurtienne Jörn , Grundgeiger Tobias
Published: April 2022

The relevance of user experience in safety–critical domains has been questioned and lacks empirical investigation. Based on previous studies examining user experience in consumer technology, we conducted an online survey on positive experiences with interactive technology in acute care. The participants of the study consisted of anaesthesiologists, nurses, and paramedics (N = 55) from three German cities. We report qualitative and quantitative data examining (1) the relevance and notion of user experience, (2) motivational orientations and psychological need satisfaction, and (3) potential correlates of hedonic, eudaimonic, and extrinsic motivations such as affect or meaning. Our findings reveal that eudaimonia was the most salient aspect in these experiences and that the relevance of psychological needs is differently ranked than in experiences with interactive consumer technology. We conclude that user experience should be considered in safety–critical domains, but research needs to develop further tools and methods to address the domain-specific requirements.
Semantic-driven multi-camera pedestrian detection
Authors: López-Cifuentes Alejandro , Escudero-Viñolo Marcos , Bescós Jesús , Carballeira Pablo
Published: April 2022

In the current worldwide situation, pedestrian detection has reemerged as a pivotal tool for intelligent video-based systems aiming to solve tasks such as pedestrian tracking, social distancing monitoring or pedestrian mass counting. Pedestrian detection methods, even the top performing ones, are highly sensitive to occlusions among pedestrians, which dramatically degrades their performance in crowded scenarios. The generalization of multi-camera setups permits to better confront occlusions by combining information from different viewpoints. In this paper, we present a multi-camera approach to globally combine pedestrian detections leveraging automatically extracted scene context. Contrarily to the majority of the methods of the state-of-the-art, the proposed approach is scene-agnostic, not requiring a tailored adaptation to the target scenario–e.g., via fine-tuning. This noteworthy attribute does not require ad hoc training with labeled data, expediting the deployment of the proposed method in real-world situations. Context information, obtained via semantic segmentation, is used (1) to automatically generate a common area of interest for the scene and all the cameras, avoiding the usual need of manually defining it, and (2) to obtain detections for each camera by solving a global optimization problem that maximizes coherence of detections both in each 2D image and in the 3D scene. This process yields tightly fitted bounding boxes that circumvent occlusions or miss detections. The experimental results on five publicly available datasets show that the proposed approach outperforms state-of-the-art multi-camera pedestrian detectors, even some specifically trained on the target scenario, signifying the versatility and robustness of the proposed method without requiring ad hoc annotations nor human-guided configuration.
Uncertainty of biomass stocks in Spanish forests: a comprehensive comparison of allometric equations
Authors: Ameztegui Aitor , Rodrigues Marcos , Granda Víctor
Published: April 2022

Biomass and carbon content are essential indicators for monitoring forest ecosystems and their role in climate action, but their estimation is not straightforward. A typical approach to solve these limitations has been the estimation of tree or stand biomass based on forest inventory data, using either allometric equations or biomass expansion factors. Many allometric equations exist, but very few studies have assessed how the calculation methods used may impact outcomes and how this impact depends on genera, functional group, climate or forest structural attributes. In this study we evaluate the differences in biomass estimates yielded by the most widely used biomass equations in Spain. We first quantify the discrepancies at tree level and among the main forest tree species. We observed that the divergences in carbon estimations between different equations increased with tree size, especially in the case of hardwoods and for diameters beyond the range used to calibrate the equations. At the plot level, we found considerable differences between the biomass values predicted using different methods (above 25% in one out of three plots), which constitutes a warning against the uncritical choice of equations to determine biomass or carbon values. The spatial representation of the differences revealed geographical patterns related to the dominance of fast-growing species such as Eucalyptus or Pinus pinaster, with a minor effect of forest structure, and almost no effect of climate. Finally, we observed that differences were mostly due to the data source rather than the modelling approach or equation used. Based on our results, BEF equations seem a valid and unbiased option to provide nation-level estimations of carbon balance, although local equations should preferably be used if they are available for the target area.
Long-term response of soil and stem wood properties to repeated nitrogen fertilization in a N-limited Scots pine stand
Authors: Smolander Aino , Henttonen Helena M. , Nöjd Pekka , Soronen Päivi , Mäkinen Harri
Published: April 2022

Nitrogen is the nutrient mainly limiting forest growth on mineral soil sites in the boreal regions. The objective of this study was to find out the response of stem wood N to repeated fertilizations and to find out their long-lasting effects on soil organic matter composition, focusing on C and N cycling processes and concentrations of condensed tannins. The site was located in a relatively unfertile Scots pine (Pinus sylvestris L.) stand in eastern Finland. The treatments were three levels of N fertilization (0, 150, 300 kg/ha) applied four times at 5-year intervals with the last addition 29 years ago. The N additions had not changed the pH of the humus layer but resulted in higher availability of N. The C-to-N ratio of organic matter decreased with increasing N addition. The treatment of 300 kg/ha increased the net N mineralization rate and the ratio of net N mineralization/microbial biomass N and decreased the amount of C in the microbial biomass and its C-to-N ratio and the concentration of condensed tannins. Net nitrification and extractable nitrate were negligible in all soils. In soil diffusive fluxes, NH4-, NO3- and amino acid-N were all detected by in situ microdialysis sampling; the results showed large variation but supported higher N availability in N fertilized soil. The N fertilization increased tree-ring widths and the effect lasted for about 10 years after the last fertilization event. Nitrogen content and the N isotopic ratio 15N/14N (δ15N) in tree-rings increased both after the first N addition in the treatment of 300 kg/ha. In conclusion, soil properties still indicated higher N availability in the N fertilized soil after three decades since the latest fertilization, but the response of tree diameter growth had faded out after a much shorter period.
Molecular and morphological identification of the alfalfa weevil larval parasitoids Bathyplectes anura and Bathyplectes curculionis to estimate the rate of parasitism
Authors: Levi-Mourao Alexandre , Muñoz Pilar , Cerda-Bennasser Pedro , Meseguer Roberto , Pons Xavier
Published: April 2022

The alfalfa weevil (Hypera postica Gyllenhal, Coleoptera: Curculionidae) is a major pest of alfalfa crops. Chemical control measures are inefficient, but the larvae are often infested by parasitoid wasps of the genus Bathyplectes Förster (Hymenoptera: Ichneumonidae), which offer a potential biological control strategy. The development of effective biological control requires the identification of parasitoid species, but conventional methods involve the rearing of parasitoids to the puparium stage for morphological confirmation. Here we designed a PCR method in which two pairs of primers are used to detect and identify Bathyplectes curculionis Thomson and Bathyplectes anura Thomson larvae in a faster way. We compared conventional rearing to the new method as a means to determine the parasitism rates caused by each species in Spain during the 2019 and 2020 seasons. In 2019, the PCR method detected five times as many B. curculionis events and twice as many B. anura events. Similarly, in 2020, the PCR method detected seven times as many B. curculionis events and twice as many B. anura events. High mortality of H. postica larvae was recorded in 2020 due to an epizootic attack by the fungus Zoophthora phytonomi Arthur (Zygomycetes: Entomophthorales), explaining the lower overall rate of parasitism and the widespread death of the larvae. Statistical analysis confirmed that the PCR method is more sensitive than conventional rearing for the detection of target parasitoids. However, only rearing can confirm the effective parasitism or the presence of unexpected species. We therefore recommend the use of both methods in parallel when evaluating host–parasitoid systems.
Warmer temperature decreases the maximum length of six species of marine fishes, crustacean, and squid in New Zealand
Authors: Lavin Charles P. , Gordó-Vilaseca Cesc , Stephenson Fabrice , Shi Zhiyuan , Costello Mark John
Published: April 2022

As global oceans continue to warm and deoxygenate, it is expected that marine ectotherms will reduce in body size resulting from the interactive effects of temperature and dissolved oxygen availability. A temperature-size response describes how wild populations of ectothermic species grow faster and reach a smaller size within warmer temperatures. While temperature-size responses are well observed in marine ectotherms, the mechanisms underpinning such a reduction in body size remain debated. Here, we analyse the relative influence of temperature, dissolved oxygen concentration, and geographic location (which encompasses multiple latent variables), on the maximum body length of four fish, one crustacean, and one squid species, which inhabit shallow to deep sea (1000 m) New Zealand waters across a temperature gradient of 1.5 to 18 °C. We found that all study species displayed a temperature-size response, with the strongest response exhibited by the largest species, hoki (Macruronus novaezelandiae). We also found that temperature was more important than dissolved oxygen concentration in determining maximum body length, as dissolved oxygen levels were at or near saturation in the study area. Our results suggest that larger-bodied species may experience the strongest temperature-size responses, and support expectations from the gill-oxygen limitation theory (GOLT) and the oxygen and capacity limited thermal tolerance (OCLTT) concept that increases in oxygen demand may be size- and temperature-dependent, thus driving a reduction in maximum body length of marine ectotherms with warming.
Collaborative capability building for critical infrastructure resilience: assessment and selection of good practices
Authors: Feletti Giada , Piraina Mariachiara , Petrenj Boris , Trucco Paolo
Published: April 2022

Accidental and intentional disruptive events affecting Critical Infrastructure (CI) systems dramatically increase on a global scale and put pressure on governments and CI operators to further improve technical and organizational capacities for securing the continuity of service. Experts in the field call for collaborative approaches to manage CI interdependencies and mitigate domino effects, which amplify the impact of disruptions over space, time and social functions. This paper presents an integrated framework for the classification, assessment and selection of Good Practices (GPs) in the Critical Infrastructure Resilience domain—‘CRAFTER’, from the perspective of collaborative Emergency Management (EM) capability building. The GPs mainly come from local and national level actions and programs, emphasizing the importance of fostering collaborative processes among stakeholders. The study identified 53 GPs through a systematic analysis of available scientific literature and research projects in the CI domain, which were used in the development of the CRAFTER framework. The framework was refined and validated through a questionnaire administered to CI experts, as a way to integrate theory-based and practitioner-based knowledge. The GPs were then classified and assessed according to their intended application context, the activities and functionalities covered, and the EM capabilities they support. The CRAFTER framework enables the assessment and benchmarking of GPs showing their strengths and weaknesses when used to build EM capabilities. It also supports practitioners in selecting a smallest effective bundle of GPS under different institutional and operational contexts, making sure that all the EM phases and capabilities are adequately covered.
Particulate Exotica
Authors: Zhang Fan
Published: April 2022

Recent advances in differential topology single out four-dimensions as being special, allowing for vast varieties of exotic smoothness (differential) structures, distinguished by their handlebody decompositions, even as the coarser algebraic topology is fixed. Should the spacetime we reside in takes up one of the more exotic choices, and there is no obvious reason why it shouldn’t, apparent pathologies would inevitably plague calculus-based physical theories assuming the standard vanilla structure, due to the non-existence of a diffeomorphism and the consequent lack of a suitable portal through which to transfer the complete information regarding the exotic physical dynamics into the vanilla theories. An obvious plausible consequence of this deficiency would be the uncertainty permeating our attempted description of the microscopic world. We tentatively argue here, that a re-inspection of the key ingredients of the phenomenological particle models, from the perspective of exotica, could possibly yield interesting insights. Our short and rudimentary discussion is qualitative and speculative, because the necessary mathematical tools have only just began to be developed.
Viscosity and Interfacial Tension of Binary Mixtures Consisting of Linear, Branched, Cyclic, or Oxygenated Hydrocarbons with Dissolved Gases Using Surface Light Scattering and Equilibrium Molecular Dynamics Simulations
Authors: Klein Tobias , Lenahan Frances D. , Zhai Ziwen , Kerscher Manuel , Jander Julius H. , Koller Thomas M. , Rausch Michael H. , Fröba Andreas P.
Published: April 2022

In the present study, the influence of the molecular characteristics of the solvent and solute on the dynamic viscosity and interfacial tension of binary mixtures consisting of a liquid with a dissolved gas is investigated using surface light scattering (SLS) and equilibrium molecular dynamics (EMD) simulations. In detail, binary mixtures consisting of linear, branched, cyclic, or oxygenated hydrocarbons and the solutes hydrogen, helium, methane, water, carbon monoxide, or carbon dioxide are studied in the temperature range between (298 and 573) K and for solute mole fractions up to 0.2. With SLS, the liquid dynamic viscosity and interfacial tension of the binary mixtures could be accessed in macroscopic thermodynamic equilibrium with average expanded uncertainties (coverage factor k = 2) of (2.4 and 2.3)%, respectively. While EMD simulations were able to predict the influence of the dissolved gases on the interfacial tension of the binary mixtures, the simulations fail to represent the influence of the dissolved gas on the viscosity. Due to the systematic variation of the solvent and solute molecules, the influence of the molecular characteristics, e.g., in the form of size, shape, or polarity, on the thermophysical properties of the mixtures is discussed. Dissolving carbon dioxide, e.g., leads to a reduction of both properties by up to 60% compared to the properties of the pure solvent. Dissolved helium, on the other hand, has only a small influence on the properties of the pure solvent. The influence of dissolved water was found to be negligible in mixtures with an alkane but strongly increases both properties when dissolved in an alcohol, which may be explained by the formation of hydrogen bonds.
Does obstructive sleep apnoea modulate cardiac autonomic function in paroxysmal atrial fibrillation?
Authors: Mohammadieh Anna Mary , Dissanayake Hasthi U. , Sutherland Kate , Ucak Seren , De Chazal Philip , Cistulli Peter A.
Published: April 2022

Purpose

The autonomic nervous system may mediate acute apnoea–induced atrial fibrillation (AF). We compared cardiac autonomic function in paroxysmal atrial fibrillation (PAF) patients with and without obstructive sleep apnoea (OSA).

Methods

Case control study of 101 patients with PAF recruited at two tertiary centres. All patients underwent in-laboratory polysomnography. ECG signal demonstrating “steady state” sinus rhythm (i.e. with arrhythmic beats and respiratory events excluded) was included in the analysis. Cardiac autonomic function was assessed via measures of heart rate variability (HRV) and reported by sleep stage (REM vs Non-REM) for patients with and without OSA.

Results

Sixty-five (66.3%) of patients were male, mean age 61.5 ± 11.6 years, mean BMI 27.1 ± 4.3 kg/m2. Global measures of HRV (triangular index, total power) did not differ between PAF patients with and without OSA in either REM or non-REM sleep. Frequency-domain analysis during non-REM sleep in PAF patients with OSA showed increased cardiac parasympathetic modulation (HF-nu: 39.1 ± 15.7 vs 48.0 ± 14.6, p = 0.008) and reduced cardiac sympathetic modulation (LF-nu 54.1 ± 19.7 vs 43.7 ± 18.0, p = 0.012, LF/HF ratio: 2.1 ± 2.0 vs 1.2 ± 1.0, p = 0.007). Results remained significant after adjusting for age, sex, and BMI (adjusted p values 0.024, 0.045 and 0.018 respectively). There were no differences in HRV parameters during REM sleep.

Conclusions

This is the first study of HRV in PAF patients with and without OSA. Our results indicate limited differences in HRV between groups. However, this work suggests a chronic increase in parasympathetic nervous modulation and relative reduction in sympathetic modulation in PAF patients with OSA during steady-state non-REM sleep.
Nanohydroxyapatite-Protein Interface in Composite Sintered Scaffold Influences Bone Regeneration in Rabbit Ulnar Segmental Defect
Authors: Radhakrishnan Janani , Muthuraj Manjula , Gandham Gnana Santi Phani Deepika , Sethuraman Swaminathan , Subramanian Anuradha
Published: April 2022

The healing physiology of bone repair and remodeling that occurs after normal fracture is well orchestrated. However, it fails in complex clinical conditions and hence requires augmentation by grafts. In this study, composite nanohydroxyapatite (nHA), poly(hydroxybutyrate) (PHB) and poly(ɛ-caprolactone) (PCL) constituted microspheres sintered three-dimensional scaffold were evaluated in rabbit ulnar segmental defect. A composite scaffold using PHB-PCL-nHA microspheres was developed with protein interface by solvent/non-solvent sintering to provide multiple cues such as biocomposition, cancellous bone equivalent meso-micro multi-scale porosity, and compressive strength. In vitro DNA quantification and alkaline phosphatase (ALP) assays revealed that the protein interfaced composite scaffolds supported osteoblast proliferation and mineralization significantly higher than scaffolds without protein and TCPS (p < 0.05). Scanning electron micrographs of osteoblasts cultured scaffolds demonstrated cell-matrix interaction, cell spreading, colonization and filopodial extension across the porous voids. Cylindrical scaffolds (5 × 10 mm) were implanted following segmental defect (10 mm) in rabbit ulnar bone and compared with untreated control. Radiography (4, 8 and 12 weeks) and µ-computed tomography (12 weeks) analysis showed directional bone tissue formation by bridging defective site in both scaffolds with and without protein interface. Whereas, undesired sclerotic-like tissue formation was observed in control groups from 8 weeks. Histology by hot Stevenel’s blue and van Gieson’s picrofuchsin staining has confirmed enhanced bone maturation in scaffold groups while presence of osteoids was observed in control after 12 weeks. Thus, the developed composite matrices exhibits osteoinductive, osteoconductive properties and demonstrates its bone regenerative potential owing to its compositional, micro & macro structural and mechanical properties.
No home for poor men: a comparative study of household debt and homeownership in Denmark and Turkey
Authors: Turk Suheyla , Gurden Burag
Published: April 2022

Homeownership rates have declined in several countries including Denmark and Turkey since 2010. A majority of the decline in homeownership has been observed among low income holders. This variation finding comparative case study compares similar patterns of neoliberal housing policies to examine wealth inequalities based on homeownership despite fundamental differences in housing markets and welfare state provision. The comparison of Denmark and Turkey reveals similar adoption of policies that support financialization as a strategy to recover from financial crises. This paper examines how states have supported financialization with policies that allowed deregulations in the housing market to create an enabling environment for construction and real estate-specific growth, and how neoliberal housing policies positioned homeownership, a wealth symbol, as the core tenet of asset-based welfare that increased wealth inequalities. The outcome of this paper shows that neoliberal housing policies have generated new forms of inequality between low and high-income earners to access housing in both countries in different ways to produce a similar outcome.
Magnetocaloric Effect for La0.54Sr0.27Gd0.19MnO3 Nanoparticles at Room and Cryogenic Temperatures
Authors: Hamad Mahmoud A. , Alamri Hatem R.
Published: April 2022

The magnetic refrigerator (MR) has gained popularity due to its potential to improve the energy efficiency of refrigeration without the use of unsafe gas, as is the case with traditional gas compression techniques. Magnetocaloric lanthanum manganite investigation, particularly at room and cryogenic temperatures, shows favorable results for the development of MR. Previous thermodynamic models require a significant amount of time and effort to estimate the magnetocaloric effect (MCE). Consequently, we employ the phenomenological model (PM), which is simple and straightforward, requiring fewer parameters than many other modeling methods. We studied the magnetocaloric effect (MCE) of silica-coated La0.54Sr0.27Gd0.19MnO3 (LSGMO) nanoparticles via PM. According to PM results, MCE parameters were obtained as the consequences of the simulated magnetization of silica-coated LSGMO nanoparticles vs. temperature under 0.1 T a magnetic field. It is revealed that the MCE of silica-coated LSGMO nanoparticles covers a broad range of temperatures between 200 and 330 K. The comparison of MCE parameters for silica-coated LSGMO nanoparticles and some published works shows that silica-coated LSGMO nanoparticles are considerably larger than some of the MCE parameters in these published works. Finally, silica-coated LSGMO nanoparticles are suitable function materials in MR, especially at room and cryogenic temperatures, contributing to efficient MR.
A Proof of Sanov’s Theorem via Discretizations
Authors: Baldasso Rangel , Oliveira Roberto I. , Pereira Alan , Reis Guilherme
Published: April 2022

We present an alternative proof of Sanov’s theorem for Polish spaces in the weak topology that follows via discretization arguments. We combine the simpler version of Sanov’s theorem for discrete finite spaces and well-chosen finite discretizations of the Polish space. The main tool in our proof is an explicit control on the rate of convergence for the approximated measures.
Academic vs. biological age in research on academic careers: a large-scale study with implications for scientifically developing systems
Authors: Kwiek Marek , Roszka Wojciech
Published: April 2022

Biological age is an important sociodemographic factor in studies on academic careers (research productivity, scholarly impact, and collaboration patterns). It is assumed that the academic age, or the time elapsed from the first publication, is a good proxy for biological age. In this study, we analyze the limitations of the proxy in academic career studies, using as an example the entire population of Polish academic scientists and scholars visible in the last decade in global science and holding at least a PhD (N = 20,569). The proxy works well for science, technology, engineering, mathematics, and medicine (STEMM) disciplines; however, for non-STEMM disciplines (particularly for humanities and social sciences), it has a dramatically worse performance. This negative conclusion is particularly important for systems that have only recently visible in global academic journals. The micro-level data suggest a delayed participation of social scientists and humanists in global science networks, with practical implications for predicting biological age from academic age. We calculate correlation coefficients, present contingency analysis of academic career stages with academic positions and age groups, and create a linear multivariate regression model. Our research suggests that in scientifically developing countries, academic age as a proxy for biological age should be used more cautiously than in advanced countries: ideally, it should be used only for STEMM disciplines.