bluuebunny/crossref_metadata_2025 huggingface dataset:
Sustaining the T-cell activity in xenografted psoriasis skin
Authors: Christensen Pernille Kristine Fisker , Hansen Axel Kornerup , Skov Søren , Engkilde Kåre , Larsen Jesper , Høyer-Hansen Maria Helena , Koch Janne
Published: January 2023

Xenografting of psoriasis skin onto immune deficient mice has been widely used to obtain proof-of-principle of new drug candidates. However, the lack of human T-cell activity in the grafts limits the use of the model. Here, we show that xenografting of lesional skin from psoriasis patients onto human IL-2 NOG mice results in increased numbers of human CD3+cells in the grafts, axillary lymph nodes and blood from human IL-2 NOG mice compared to C.B-17 scid and NOG mice. In addition, disease relevant human cytokine levels were higher in graft lysates and serum from human IL-2 NOG mice. However, the epidermis was lacking and no efficacy of ustekinumab, a human anti-P40 antibody targeting both IL-12 and IL-23, was shown. Thus, despite the sustained T-cell activity, the model needs further investigations and validation to capture more aspects of psoriasis.
Gender differences in dry eye disease symptoms associated with psychological health indicators among adults using mobile mental health apps
Authors: Kim Hyojin , An Youngju , Hwang Won Ju
Published: January 2023

Purpose

We aimed to investigate the association between dry eye disease (DED) symptoms and mental health among Korean adults in the community.

Methods

A cross-sectional study analyzed the data of 152 participants using mobile-phone applications for recording mental health. We defined individuals with DED symptoms as those who experienced a sense of irritation or dryness of the eye (either constantly or often). Mental health (perceived stress, depression, and anxiety) was assessed using the Perceived Stress Scale, Patient Health Questionnaire-9, and General Anxiety Disorder-7, in this order. Multiple logistic regression analysis was conducted to examine the association between DED symptoms and mental health. We also adjusted for possible covariates. We investigated sex differences in mental health status in relation to DED.

Results

We found that 41.4% of the participants (48.4% female and 30.5% male) showed DED symptoms, and its prevalence was higher in female than in male. The average perceived stress and anxiety symptoms in the female with DED (24.69±4.73 and 6.56±5.09, respectively) were significantly higher than those without DED (21.38±4.68 and 4.54±4.03) (p = 0.020 and 0.038, respectively). Even after adjusting for possible covariates, female who had DED showed higher risks of perceived stress (OR = 1.28), depression (OR = 2.64), and anxiety (OR = 5.81).

Conclusions

Clinicians and nurses should therefore be aware of the possibility of mental health problems among female with DED.
Patient hesitancy in perioperative clinical trial enrollment during the COVID-19 pandemic
Authors: Chirinos Josue D. , Turco Isabella S. , Di Fenza Raffaele , Gianni Stefano , Larson Grant M. , Swingle Joseph F. , Akeju Oluwaseun , Berra Lorenzo
Published: January 2023

The COVID-19 pandemic has caused tremendous disruptions to non-COVID-19 clinical research. However, there has been little investigation on how patients themselves have responded to clinical trial recruitment during the COVID-19 pandemic. To investigate the effect of the COVID-19 pandemic on rates of patient consent to enrollment into non-COVID-19 clinical trials, we carried out a cross-sectional study using data from the Nitric Oxide/Acute Kidney Injury (NO/AKI) and Minimizing ICU Neurological Dysfunction with Dexmedetomidine-Induced Sleep (MINDDS) trials. All patients eligible for the NO/AKI or MINDDS trials who came to the hospital for cardiac surgery and were approached to gain consent to enrollment were included in the current study. We defined “Before COVID-19” as the time between the start of the relevant clinical trial and the date when efforts toward that clinical trial were deescalated by the hospital due to COVID-19. We defined “During COVID-19” as the time between trial de-escalation and trial completion. 5,015 patients were screened for eligibility. 3,851 were excluded, and 1,434 were approached to gain consent to enrollment. The rate of consent to enrollment was 64% in the “Before COVID-19” group and 45% in the “During COVID-19” group (n = 1,334, P<0.001) (RR = 0.70, 95% CI 0.62 to 0.80, P<0.001). Thus, we found that rates of consent to enrollment into the NO/AKI and MINDDS trials dropped significantly with the onset of the COVID-19 pandemic. Patient demographic and socioeconomic status data collected from electronic medical records and patient survey data did not shed light on possible explanations for this observed drop, indicating that there were likely other factors at play that were not directly measured in the current study. Increased patient hesitancy to enroll in clinical trials can have detrimental effects on clinical science, patient health, and patient healthcare experience, so understanding and addressing this issue during the COVID-19 pandemic is crucial.
White matter microstructure and receptive vocabulary in children with cerebral palsy: The role of interhemispheric connectivity
Authors: Laporta-Hoyos Olga , Pannek Kerstin , Pagnozzi Alex M. , Fiori Simona , Boyd Roslyn N.
Published: January 2023

Background

Communication and cognitive impairments are common impediments to participation and social functioning in children with cerebral palsy (CP). Bilateral language networks underlie the function of some high-level language-related cognitive functions.

Purpose

To explore the association between receptive vocabulary and white-matter microstructure in the temporal lobes and the central part of the temporo-temporal bundles in children with CP.

Materials and methods

37 children with spastic motor type CP (mean age 9.6 years, 25 male) underwent a receptive vocabulary test (Peabody Picture Vocabulary Test, PPVT-IV) and 3T MRI. Mean fractional anisotropy (FA) and mean diffusivity (MD) were calculated for the temporal lobes and the interhemispheric bundles traversing the splenium of the corpus callosum and the anterior commissure. Associations between microstructure and receptive vocabulary function were explored using univariable linear regression.

Results

PPVT-IV scores were significantly associated with mean white matter MD in the left temporal lobe, but not the right temporal lobe. There was no association between PPVT-IV and mean white matter FA in the temporal lobes. PPVT-IV scores were not significantly associated with the laterality of these diffusion tensor metrics. Within the corpus callosum, FA, but not MD of the temporo-temporal bundles was significantly associated with the PPVT-IV scores. Within the anterior commissure no equivalent relationship between diffusion metrics and PPVT-IV was found.

Conclusion

Our findings add further understanding to the pathophysiological basis underlying receptive vocabulary skills in children with CP that could extend to other patients with early brain damage. This study highlights the importance of interhemispheric connections for receptive vocabulary.
High tissue expression of TLRs combined with high density of tumor infiltrating lymphocytes predicts a better prognosis in colorectal cancer patients
Authors: Beilmann-Lehtonen Ines , Kasurinen Jussi , Hagström Jaana , Kaprio Tuomas , Böckelman Camilla , Haglund Caj
Published: January 2023

Background

Colorectal cancer causes 935,000 cancer deaths yearly. High local immune cell infiltration serves as a positive prognostic factor in CRC. Toll-like receptors (TLRs) induce innate immune responses and lead to adaptive immune system activation. TLRs play protumorigenic and antitumorigenic roles. We aimed to explore the relationship between TLR immunoexpressions and the infiltration densities of T-lymphocytes in CRC.

Methods

Immunohistochemical TLR2, TLR4, TLR5, and TLR7 positivity and the density of CD3- and CD8-positive cells in tumoral and stromal tissue were evaluated from the tissue microarray slides of 549 consecutive CRC surgical patients treated at Helsinki University Hospital, Finland, between 1998 and 2005. We calculated the associations and correlations using Pearson’s chi-square and Spearman’s correlation tests, generating survival curves using the Kaplan–Meier method.

Results

Positive intratumoral CD3 and CD8 densities associated with a high TLR2 expression (p < 0.001 and p = 0.001, respectively) and a high TLR4 expression (p = 0.013 and p = 0.025). A low TLR5 immunoexpression associated with negative intratumoral CD3 (p = 0.001) and CD8 (p = 0.011) and a low stromal CD3 (p = 0.001). No association or correlation emerged between TLR7 immunoexpression and CD3 or CD8 cell density. A low CD3–CD8 tumor–stroma index indicated a worse prognosis among all TLR subgroups, except the TLR7-negative subgroup.

Conclusions

We detected significant associations and correlations between high tissue TLR2, TLR4, and TLR5 immunoexpressions and high densities of CD3- and CD8-positive cells. Combining these markers may improve the prognostic evaluation of CRC patients.
Trends in suicide rates by race and ethnicity among members of the United States Army
Authors: Brenner Lisa A. , Forster Jeri E. , Walsh Colin G. , Stearns-Yoder Kelly A. , Larson Mary Jo , Hostetter Trisha A. , Hoffmire Claire A. , Gradus Jaimie L. , Adams Rachel Sayko
Published: January 2023

Efforts were focused on identifying differences in suicide rates and time-dependent hazard rate trends, overall and within age groups, by race and ethnicity among United States Army members who returned from an index deployment (October 2007 to September 2014). This retrospective cohort study was conducted using an existing longitudinal database, the Substance Use and Psychological Injury Combat Study (SUPIC). Demographic (e.g., race and ethnicity) and military data from the Department of Defense compiled within SUPIC, as well as Department of Veterans Affairs data were linked with National Death Index records (through 2018) to identify deaths by suicide including those that occurred after military service. The cohort included 860,930 Army Service members (Active Duty, National Guard, and Reserve). Age-adjusted (using the direct standardization method) and age-specific suicide rates per 100,000 person years were calculated and rate ratios (RR) were used for comparisons. Trends were evaluated using hazard rates over time since the end of individuals’ index deployments. Among those aged 18–29 at the end of their index deployment, the suicide rate for American Indian/Alaskan Native (AI/AN) individuals was 1.51 times higher (95% confidence interval [CI]: 1.03, 2.14) compared to White non-Hispanic individuals (WNH), and lower for Hispanic and Black non-Hispanic (BNH) than for WNH individuals (RR = 0.65 [95% CI: 0.55, 0.77] and RR = 0.71 [95% CI: 0.61, 0.82], respectively). However, analyses revealed increasing trends in hazard rates post-deployment (≤ 6.5 years) within groups of Hispanic and BNH individuals (Average Annual Percent Change [APC]: 12.1% [95% CI: 1.3%, 24.1%] and 11.4% [95% CI: 6.9%, 16.0%], respectively) with a smaller, increase for WNH individuals (APC: 3.1%; 95% CI: 0.1%, 6.1%). Findings highlight key subgroups at risk for post-deployment suicide (i.e., WNH, AI/AN and younger individuals), as well as heterogeneous trends overtime, with rates and trends varying within race and ethnic groups by age groups. Post-deployment suicide prevention efforts that address culturally relevant factors and social determinants of health associated with health inequities are needed.
Using qualitative interviews to identify patient-reported clinical trial endpoints and analyses that are the most meaningful to patients with advanced breast cancer
Authors: Flood Emuella , Krasnow Anna , Orbegoso Cecilia , Karantzoulis Stella , Bailey Julie , Bayet Solène , Elghouayel Arthur , Foxley Andrew , Sommavilla Roberto , Schiavon Gaia
Published: January 2023

Background

Designing clinical trials with the emphasis on the patient-centered approach and focusing on clinical outcomes that are meaningful to patients is viewed as a priority by drug developers, regulatory agencies, payers, clinicians, and patients. This study aimed to capture information on clinical trial endpoints that would be most important and relevant for patients with advanced breast cancer, based on patient-reported outcomes.

Methods

Patients with either advanced triple-negative breast cancer [TNBC] and a maximum of two lines of systemic therapy or hormone receptor-positive/human epidermal growth factor receptor 2-negative [HR+/HER2−] breast cancer and a maximum of three lines of systemic therapy, participated in semi-structured concept elicitation interviews. Concept saturation was assessed. A sign, symptom, or impact was defined as “salient” if mentioned by ≥ 60% of participants, with an average bother rating of ≥ 5 (0–10 Scale). Participants were also asked about treatment priorities and to evaluate hypothetical scenarios showing different health-related functioning and quality-of-life treatment outcomes, using graphical representations.

Results

Thirty-two participants (97% women; aged 29+ years) with TNBC (n = 17) or HR+/HER2− breast cancer (n = 15) provided generally similar reports on symptom experience, with fatigue and pain being most salient, though importance of certain treatment-related symptoms varied between the two groups. Patients reported consistent perspectives on the importance of treatment outcomes: when considering a new treatment, they prioritized efficacy of the therapy, acceptable tolerability, stability, predictability of symptoms over time, and the duration of preserved health-related quality of life and physical functioning. The meaningful difference in preserved physical functioning was 2–3 months for 46% of participants with TNBC, whereas for most participants with HR+/HER2− breast cancer it started from 6–7 months. Both groups of participants found it easier to accept some toxicity at the beginning of therapy if it was followed by improvement, as opposed to improvement followed by deterioration.

Conclusion

The results may help to inform the design of patient-centered clinical trials, to interpret health-related quality of life and/or patient-reported outcomes, and to optimize care for patients with advanced breast cancer.
Immune-related pan-cancer gene expression signatures of patient survival revealed by NanoString-based analyses
Authors: D’Angelo Alberto , Kilili Huseyin , Chapman Robert , Generali Daniele , Tinhofer Ingeborg , Luminari Stefano , Donati Benedetta , Ciarrocchi Alessia , Giannini Riccardo , Moretto Roberto , Cremolini Chiara , Pietrantonio Filippo , Sobhani Navid , Bonazza Debora , Prins Robert , Song Seung Geun , Jeon Yoon Kyung , Pisignano Giuseppina , Cinelli Mattia , Bagby Stefan , Urrutia Araxi O.
Published: January 2023

The immune system plays a central role in the onset and progression of cancer. A better understanding of transcriptional changes in immune cell-related genes associated with cancer progression, and their significance in disease prognosis, is therefore needed. NanoString-based targeted gene expression profiling has advantages for deployment in a clinical setting over RNA-seq technologies. We analysed NanoString PanCancer Immune Profiling panel gene expression data encompassing 770 genes, and overall survival data, from multiple previous studies covering 10 different cancer types, including solid and blood malignancies, across 515 patients. This analysis revealed an immune gene signature comprising 39 genes that were upregulated in those patients with shorter overall survival; of these 39 genes, three (MAGEC2, SSX1 and ULBP2) were common to both solid and blood malignancies. Most of the genes identified have previously been reported as relevant in one or more cancer types. Using Cibersort, we investigated immune cell levels within individual cancer types and across groups of cancers, as well as in shorter and longer overall survival groups. Patients with shorter survival had a higher proportion of M2 macrophages and γδ T cells. Patients with longer overall survival had a higher proportion of CD8+ T cells, CD4+ T memory cells, NK cells and, unexpectedly, T regulatory cells. Using a transcriptomics platform with certain advantages for deployment in a clinical setting, our multi-cancer meta-analysis of immune gene expression and overall survival data has identified a specific transcriptional profile associated with poor overall survival.
Nutritional status and its associated factors among under five years Muslim children of Kapilvastu district, Nepal
Authors: Bhusal Chet Kant , Bhattarai Sigma , Chhetri Pradip , Myia Salau Din
Published: January 2023

Background

Malnutrition is a major public health problem throughout the world especially in Southeast Asia. This study aims to find out nutritional status and its associated factors among under five Muslim children of Kapilvastu district Nepal.

Methods

Community based cross-sectional study was conducted among 336 under five Muslim children in Kapilvastu district Nepal from December 2021 to May 2022. Multistage probability random sampling was used. Among ten local units, three were selected randomly. Then from selected three units, two wards from each unit which covers large proportion of Muslim were selected purposively. After selecting wards, listing of household having children 6 to 59 months was done with the help of Female Community Health Volunteers and 56 children were selected by simple random sampling from each wards.

Results

About half of Muslim children were underweight, 0.9% were overweight, 17.3% were wasted and 63.1% were stunted. Children with >4 members in family (AOR = 2.82, CI: 1.25–6.38), joint/extended family (AOR = 0.33, CI: 0.16–0.68), living with other than parents (AOR = 2.68, CI: 1.38–5.21), mother having primary (AOR = 2.59, CI: 1.09–6.10) and fathers having SLC and above education (AOR = 0.41, CI: 0.19–0.89), school going children (AOR = 0.27, CI: 0.15–0.48), no having agricultural land (AOR = 2.68, CI: 1.55–4.65), history of chronic diseases (AOR = 3.01, CI = 1.06–8.54) were significantly associated with underweight. Mothers having secondary (AOR = 0.30, CI: 0.10–0.88) and fathers having primary education (AOR = 3.50, CI: 1.26–9.74), school going children (AOR = 0.16, CI: 0.06–0.41), no having own land (AOR = 4.73, CI: 2.13–10.48), history of child chronic disease (AOR = 3.55, CI = 1.38–9.12) were significantly associated with wasting. Similarly, male children (AOR = 1.70, CI: 1.01–2.85), living in rural area (AOR = 0.17, CI: 0.09–0.31), joint/extended family (AOR = 0.28, CI: 0.13–0.64), living with other than parents (AOR = 3.71, CI: 1.84–7.49), fathers having secondary education (AOR = 0.50, CI: 0.27–0.94) and no having own land (AOR = 1.95, CI: 1.13–3.37) were significantly associated with stunting.

Conclusions

Underweight, wasting and stunting in under-five Muslim children were above the cutoff point from the significant level of public health and higher than national data. Hence, this study suggests collaborative and immediate attention from responsible governmental and non-governmental organizations working in nutrition for providing informal learning opportunity, intervention regarding parental support to child, school enrolment at appropriate age, prevention and treatment of children’s chronic diseases, intervention for income generating activities and addressing problems of household food insecurity among Muslim communities.
A featureless approach for object detection and tracking in dynamic environments
Authors: Zohaib Mohammad , Ahsan Muhammad , Khan Mudassir , Iqbal Jamshed
Published: January 2023

One of the challenging problems in mobile robotics is mapping a dynamic environment for navigating robots. In order to disambiguate multiple moving obstacles, state-of-art techniques often solve some form of dynamic SLAM (Simultaneous Localization and Mapping) problem. Unfortunately, their higher computational complexity press the need for simpler and more efficient approaches suitable for real-time embedded systems. In this paper, we present a ROS-based efficient algorithm for constructing dynamic maps, which exploits the spatial-temporal locality for detecting and tracking moving objects without relying on prior knowledge of their geometrical features. A two-prong contribution of this work is as follows: first, an efficient scheme for decoding sensory data into an estimated time-varying object boundary that ultimately decides its orientation and trajectory based on the iteratively updated robot Field of View (FoV); second, lower time-complexity of updating the dynamic environment through manipulating spatial-temporal locality available in the object motion profile. Unlike existing approaches, the snapshots of the environment remain constant in the number of moving objects. We validate the efficacy of our algorithm on both V-Rep simulations and real-life experiments with a wide array of dynamic environments. We show that the algorithm accurately detects and tracks objects with a high probability as long as sensor noise is low and the speed of moving objects remains within acceptable limits.
Megszemélyesítő konceptualizációk a látás, hallás és szaglás fogalmi tartományában
Authors: Galac Ádám
Published: January 2023

A tanulmány a látás, hallás és szaglás fogalmi tartományát érintő megszemélyesítő konceptualizációkat vizsgálja a magyar és az angol nyelvben. Kezdeti kérdésfeltevése az, hogy milyen szerepet játszik a megszemélyesítés mint konceptuális metafora a három észlelési modalitás érzeteinek, illetve az érzeteket kiváltó ingereknek nyelvi konceptualizációjában. Az adatok a TenTen korpuszcsalád magyar és angol alkorpuszában végzett kulcsszavas keresésekből származnak, amelynek során 9 magyar és 9 angol kulcsszó összesen közel 7000 kontextuális előfordulását annotáltam manuálisan. Az elemzésben Dorst–Mulder–Steen (2011) osztályozását követve megkülönböztetem az újszerű, a konvencionalizálódott, az alapbeállítású (default) és a metonimikus megszemélyesítéseket, de a vizsgálatot kiterjesztem a megelevenítésekre, továbbá a megszemélyesítésnek nem nevezhető, ámde közeli rokonságban álló konceptualizációkra is (aktív ágens, figuratív mozgás). Mindkét nyelvben a látás kulcsszavai eredményezték a legkevesebb megszemélyesítést; a hallás és szaglás a magyarban hasonló gyakoriságot mutat, az angolban azonban kiemelkedik a szaglás.
How Blockchain Network Factors and Market Forces Determine Bitcoin Returns
Authors: Gbadebo Adedeji Daniel
Published: January 2023

The creation of distributed ledgers technologies spirals secured peer-to-peer interactions that pave way for the invention of Bitcoin. Since its invention, the price of Bitcoin has exhibited excessive volatility and has attracted increasing attentions. The study considers the isolated influence of network activities, mining (technology) and market information as fundamental drivers of bitcoin prices. A long-term equilibrium and short-term dynamic relationship is confirmed amongst endogenous system’s variables in the VEC Model. This suggests that any deviation from the equilibrium dynamics due to perturbations of market forces (bitcoin supply and trade volume), mining information (network difficulty, Hashrate and transaction fees) as well as the network activity (confirmed payments and users adoptions) would be minimised. The model explains that the cointegration relationship has a reverse adjustment effect on bitcoin return. This justifies why Bitcoin price, and by implication the return, continues to experience different massive run-up, spiky protrusions, resistance, reversals, strong supports and consolidations in the short. Amongst others, the study recommends that there should be increase in regulation to curb excessive fluctuations that can cause significant loss to the returns and discourage digital investors.
Benchmarking gradient based Optimizers' sensitivity to Learning Rate
Authors: Guha Rehan
Published: January 2023

Initial choice of Learning Rate is a key part of gradient based methods and has a great effect on the performance of the Deep Learning Model.

This paper studies the behavior of multiple gradient based optimization algorithm which are commonly used in Deep Learning and compare their performance on various learning rate. As observed popular choice of optimization algorithms are highly sensitive to various choice of learning rates.

Our goal is to find which optimizer has an edge over others for a specific setting. We look at two datasets namely MNIST and CIFAR10 for benchmarking. The results are quite surprising, and it will help us to choose a learning rate more efficiently.
Achalasia Complicated with Bilateral Bronchial Fistulas: A Case Report and a Literature Review
Authors: Msheik Ali , Assi Farah , Tarhini Charif , Chamas Samer
Published: January 2023

Achalasia manifests as lack ofperistalsis of the esophagus. It is a common disease of a usually benign course. The incidence of esophageal-bronchial fistulahas been reported in the literature. In this study, we present the case of a patient, who was previously diagnosed with achalasia. He was received at the emergency department (ED) having respiratory failure and cardiopulmonary arrest. Resuscitation followed by radiological and laboratory workup revealed acute respiratory distress syndrome and bilateral esophageal-bronchial fistulas. Attempt to do surgical intervention was limited due to the severe sepsis and compromised respiratory status of the patient. Discussion of this case in light of the literature findings reveals the possible treatment methods and prognosis of similar conditions.
The approach to diagnosis and management of corneal ulcers
Authors: Benesia Mark
Published: January 2023

Corneal ulcers are among the major causes of corneal blindness. The cause of corneal ulceration is a variety of infections. The key to improving clinical and visual results in cases of corneal ulcers is an accurate, speedy diagnosis and rapid treatment. However, there are no established standards or guidelines for treating corneal ulcers. Even seasoned eye care professionals occasionally have trouble predicting how the disease will progress in most patients. This article makes an effort to offer a general overview of the diagnosis process and treatment plan for a corneal ulcer.
Dysphagia Days as an Assessment of Clinical Treatment Outcome in Eosinophilic Esophagitis
Authors: Hirano Ikuo , Rothenberg Marc E. , Zhang Sandra , de Oliveira Claudia , Charriez Christina M. , Coyne Karin S. , Bacci Elizabeth Dansie , Dellon Evan S.
Published: January 2023

INTRODUCTION:

The aim of this study was to evaluate Dysphagia Days as a measure of symptom improvement in patients with eosinophilic esophagitis from the HEROES study.

METHODS:

Dysphagia Days, defined as a yes answer to the following question: During any meal today, did food go down slowly or get stuck in your throat or chest? was assessed for cendakimab vs placebo.

RESULTS:

A statistically significant reduction in the mean number of Dysphagia Days experienced was observed with cendakimab 360 mg vs placebo at week 16 (−4.67 vs −1.83; P = 0.0115); an even greater improvement was observed in steroid-refractory patients vs placebo (−4.48 vs −0.04; P = 0.0079).

DISCUSSION:

Dysphagia Days represents a relevant clinical end point to capture dysphagia-related symptoms.
Atelier, czyli tam i z powrotem. Ewolucja filmu studyjnego od czasów kina niemego do ery cyfrowej
Authors: Kalbarczyk Kamil
Published: January 2023

The article explores the concept of studio filmmaking in the context of early Hollywood and a new incarnation of studio filmmaking in the age of digital visual effects. The author analyses the old studio era in terms of shaping the cinematic image (primarily compositing) and the meaning of the studio, understood as an atelier. Kalbarczyk argues that originally the final look of the film used to be achieved by blending all the shot elements in the physical space of the studio, while nowadays the final form is most often created in a virtual space, deepening the decentralization of the filmmaking process. The author argues that more than the atelier space, the new studio filmmaking concept would refer to the holistic way of thinking about cinema as a heterogeneous structure, not so much attained integrally through filming, but carefully constructed. Various dimensions of studio filmmaking are discussed using the following films: Sunrise: A Song of Two Humans (1927), Citizen Kane (1941), Everest (2015) and Avengers: Endgame (2019).
Products From Building an Engineering Model for Stem Education Activity
Authors: GÜDER Yunus , GÜRBÜZ Ramazan
Published: January 2023

The aim of this study is to examine whether the purpose of the Engineering Model Eliciting Activities (EngMEAs) are to be used as a tool to bridge engineering and school mathematics in the transition to STEM education. To this end, researchers have developed "Traffic Lights Problem", which has an interdisciplinary nature, working with mathematics teacher. This problem was applied to two groups of 3 and 4 students studying in the 7th grade in a city center in the eastern region of Turkey in the 2017-2018 academic year. In the process of solving the problem, the students used mathematics, science, technology and engineering knowledge in an integrated structure and introduced their own mathematical and scientific ideas and supported these ideas with in-group discussions and presented different models (products). The models of the students were different from each other because of students’ first exposure to such a process, different way of thoughts in the groups and inherent complexity of the modelling problems. In the light of the findings, it was concluded that the traffic lights modeling problem had an interdisciplinary nature, and this problem may have an important function for STEM education.
Ulrich trichotomy on del Pezzo surfaces
Authors: Coskun Emre , Genc Ozhan
Published: January 2023

We use a correspondence between Ulrich bundles on a projective variety and quiver representations to prove that certain del Pezzo surfaces satisfy the Ulrich trichotomy, for any given polarization.
Laughing to love science: contextualizing science comedy
Authors: Bankes Edward Thomas
Published: January 2023

Over the last fifteen years, there has been growing interest in the use of comedy within science communication. This paper seeks to contextualize the emergence of science comedy, analyzing the construction of comedy within academic literature as a means for bolstering the cultural authority of science. Drawing specifically from Mikhail Bakhtin’s work on power and language, academic constructions of science comedy might be read as an orchestrated moment of carnival, with humor imagined as a means for engineering public support for science, on the premise that science communicators alone should determine what version of science the public receive. However, results from a pilot study interviewing London-based science comedians suggests that such ambitions are not shared by performers. Performers framed the value of science comedy lying predominantly in the opportunity to challenge other science communicators’ own attitudes to science. Framing scientists and science communicators as science comedy’s most relevant audience, rather than the public, performers envisaged comedy as a space in which the unspoken assumptions of science could be exposed and negotiated.
Advances in silicon-based, integrated tunable semiconductor lasers
Authors: Yang Changjin , Liang Lei , Qin Li , Tang Hui , Lei Yuxin , Jia Peng , Chen Yongyi , Wang Yubing , Song Yu , Qiu Cheng , Zheng Chuantao , Zhao Huan , Li Xin , Li Dabing , Wang Lijun
Published: January 2023

Tunable semiconductor lasers have many important applications such as wavelength division multiplexing, light detection and ranging, and gas detection. The increased interest in silicon photonics has led to the rapid development of miniaturized on-chip tunable semiconductor lasers. However, silicon has poor light-emitting properties. Therefore, realizing high-performance tunable semiconductor lasers requires the integration of light sources with silicon. In this study, we review silicon-based light source integration methods and the development of silicon-based integrated tunable semiconductor lasers. Considering that narrow-linewidth performance greatly expands the applications of tunable semiconductor lasers, methods for reducing the linewidth of tunable lasers are summarized. Finally, the development trends and prospects for silicon-based integrated light sources and silicon-based integrated tunable lasers are analyzed and discussed.
Nonlinear analysis and processing of software development data under Internet of things monitoring system
Authors: Zhang Peipeng , Li Junya , Sharma Anjali
Published: January 2023

The most important and core technology of the Internet of things (IoT) is still the internet, and it also includes many other technical fields and is applied to many fields. The various processes of IoT data are the guarantee that the IoT can meet the management and management requirements in a certain application field, so that each application field can better meet the requirements of people’s lives. In order to study the nonlinear analysis and processing of software development data under the IoT monitoring system, this work uses QT software and socket programming to build the detection, control, and transmission module of the system, and uses multiple processes to classify and process the data. The user interface technology is used to display the data in real time. The system can control the type of transmitted data through interface operation. The classified transmission of data is realized, and the transmission speed is guaranteed to be about 50 MB/s. The experimental results show that after the functional design of each module is completed, the whole system is finally tested to determine whether the system can meet the requirements of data transmission, control, and processing. Since these data are simulated data, video playback is used to simulate the occurrence of a real accident. When an abnormal situation occurs, the whole system starts to work. If an accident occurs, a signal is sent after the accident. The system not only ensures the intellectualization of control, but also ensures the rapidity of data transmission.
Prediction of Upper-Body Power During the Seated Medicine Ball Throw in Older Women
Authors: Parrino Rosalia L. , Strand Keri L. , San Ly Anna , Barry Sarah S. , Liscano Jose A. , Trebotich Luca , Martin-Diala Chimaobim , Martin Erick , Signorile Joseph F.
Published: January 2023

Parrino, RL, Strand, KL, San Ly, A, Barry, SS, Liscano, JA, Trebotich, L, Martin-Diala, C, Martin, E, and Signorile, JF. Prediction of upper-body power during the seated medicine ball throw in older women. J Strength Cond Res 37(8): 1679–1686, 2023—Upper-body power, the product of muscular strength and movement velocity, is a core measure used by clinicians and researchers alike, to assess functional independence in older persons. Nevertheless, the evaluation of upper-body power is often impractical due to prohibitive cost, as well as space, equipment, and technical demands. Therefore, this study was designed to establish a predictive equation for upper-body peak power (PPUB) using the seated medicine ball throw (SMBT). Thirty-five older women (75.2

6.4y) completed the SMBT and pneumatic resistance chest press peak power (CPPP) testing. A stepwise multiple regression was used to produce a predictive model using CPPP to assess PPUB. The model included SMBT distance (SMBTD) and medicine ball mass (MBMass) as significant predictors (PPUB[W] = 96.719·SMBTD [m] + 37.164·MBMass [kg]–104.499; r = 0.752; SEE = 41.41 W; p < 0.001). The performance of this model was confirmed through a cross-validation analysis using 70% (n = 23; r = 0.709; p < 0.001) and 30% (n = 12; r = 0.823; p < 0.001) of the sample. Reliability was confirmed using intraclass correlation, coefficient of variation, standard error of measurement, and Bland-Altman analyses for both MBMass. This model provides an easily accessible and reliable tool, using SMBTD and MBMass, for predicting PPUB in older women as a marker of quality of life, functional independence, and ability to complete activities of daily living.
Measuring Dependency of International Trade Aerospace Sector
Authors: Perwitasari Intan , Prayudya Daffa Rizqi
Published: January 2023

This research aims to quantify the specialization stage of Indonesia, followed by the dependencies of Indonesia's imports on the aerospace sector. Since, there are still few studies about the aerospace sector, especially from an economic perspective. This research conducted to fulfill the gap studies on international trade aerospace sector phenomenon. The sample used in this research is 9 countries between 2001 – 2018. Methods will be conducted in two steps. First, by using Trade Specialization Index (TSI), we try to identify the specialization stage of each country in the aerospace sector. Second, we used Import Dependency Ratio (IDR) to identify the level of Indonesia's dependency in the aerospace sector on other countries. We found that Indonesia still reaching the introduction stage of specialization. Adding relevancy to the result, Indonesia is also considered as highly-dependent on other countries in terms of the aerospace sector. We therefore suggest that Indonesia needs to raise traction in the aerospace sector by increasing its budget and conducting technology transfers, so Indonesia’s competitiveness will raised.
Diversification of Indonesian Export Markets to Non-Traditional Countries
Authors: Riyanto Guntur , Widyastutik Widyastutik , Krisnamurthi Bayu , Almasyhari Abdul Kharis
Published: January 2023

The Ukraine-Soviet Union war and the Covid-19 pandemic made the world economy experience complex problems. Indonesia was also affected, especially the decline in exports, so it needed to find new trading partners. This study aims to determine the potential diversification of Indonesia's export market to non-traditional countries, namely Turkey, Brazil, Georgia and the Russian Federation as well as 10 economic commodities. The data used in this study is secondary data. This data is obtained through the GTAP database (Global Trade Analysis Project) version 10. In this GTAP database there are input - output data from 121 countries representing 98% of world GDP. The results of this study are Brazil and Turkey can become Indonesia's trading partners, while Georgia and the Russian Federation have little opportunity to establish trade cooperation with Indonesia
Does Fiscal Decentralization Affect Poverty? An Empirical Study
Authors: Widyastuti Ariyani , Nusantara Agung
Published: January 2023

The Poverty percentage in Central Java ranked two throughout Java Island after DI Yogyakarta Province. It surely causes gaps and inequality between regions in Central Java Province. This study attempted to analyze the effects of fiscal decentralization, fiscal balance fund, and economic growth on the poverty in 35 regencies/ cities in Central Java Province within 2016-2020. By using a quantitative approach, this study used a panel analysis with a Fixed Effect Model (FEM) method. Based on the results of panel data regression analysis results, fiscal decentralization and fiscal balance fund had no relationship with the poverty in Central Java. On the other hand, economic growth had positive and significant effects. High economic growth will reduce poverty rate when the economic activities carried out are padat karya which aims at absorbing workforce. High workforce absorption will reduce the poverty rate.
Does Village Fund Have an Impact Toward Economic Growth?
Authors: Fazri Muhammad , Alwi Paluseri A. Risdawati , Oktarina Adelia , Imron Dian Karinawati , Nababan Febrina Elia , Pertiwi Cita , Roidatua Marthella Rivera , Aryani Yulya
Published: January 2023

Indonesia Village Fund policy aims to foster local democracy and rural development through direct funds allocation. During the last seven years (2015-2022), the government has provided Village Fund 400,1 trillion rupiahs (278,3 billion dollars) and continues to increase every year. Numerous studies discover the Village Fund impact on economic conditions but are limited to village scale. This study intends to analyze the impact of the Village Fund on a macro scale, point on the economic growth of a region, specifically on disadvantaged regions. The study conducted through quantitative methods used the panel data approach. The data covers 416 districts from 2015 to 2019. The result shows that the Village Fund has a significant effect, but the value of the effect on GDPR (Gross Domestic Product of Region) is lower than other variables. The effect of Village Fund in disadvantaged regions is greater than in non-disadvantaged regions, which indicates growth acceleration in disadvantaged regions.
Responsabilidad social empresarial y el desarrollo de la comunidad en el entorno de la compañía minera 2018
Authors: Carlín Villarreal Víctor Martin
Published: January 2023

In countries where mining activity is one of the most important sources of income, there is a constant interest in identifying those management practices that make it possible to satisfy the needs and perspectives of the population, among which corporate social responsibility deserves special mention. The purpose of this research was to establish the correlation between corporate social responsibility and community development in the environment surrounding a mining company. This was a non-experimental research study with a correlational design and non-probabilistic sampling; the sample consisted of the company’s workers and the local inhabitants. The technique used was the survey, and the questionnaire was used as the data collection instrument, which met the criteria of validity and reliability (Cronbach’s alpha coefficient = 0.833). Social responsibility dimensions such as “ethics” (information transparency), “sustainability” (participation and mutual benefit), “human capital” (human resources management and occupational safety) and “safety” (change adjustment and impact management) stand out from the instrument, as they are specific to the reality of the study. From the results, it is evident that there is a high correlation (r = 0.964) between the two research variables, social responsibility and community development, due to the high and significant correlation between the two.
“BELOBEREZHSKIY PATERIK”: COMPOSITION, SOURCES, GENRE
Authors: Fedorova Irina
Published: January 2023

“Beloberezhsky Paterik” is preserved in the manuscript of the Department of Manuscripts of the Russian National Library (P. N. Tikhanov collection, no. 214) and consists of materials related to the Beloberezhskaya hermitage, founded in the early 18th century in the White Shore tract near Bryansk. The main purpose of the article was to determine the conformity of the “Beloberezhsky Paterik” to the genre canon. The work analyzes the genre composition, configuration, principles of material organization, and establishes the sources and time of compiling the collection . The analysis was carried out with regard to the tradition of ancient Russian patericons and the development of late patericography. As the study demonstrated, the constant features of the genre organically manifested themselves in the “Beloberezhsky Paterik.” Thus, the complex composition of the collection allowed to consider it as an ensemble that includes traditional patericon forms: legends about icons, parochial chronicles, patericon Lives, the Life of the founder of the monastery and the hermit's Life, miracles and visions. The “memory of the genre” also manifested itself on other levels: unification of material by topographical feature, cyclization and the chronological principle of data organization, simplicity of the narrative style, themes and motives traditional for the patericon Life (the theme of hermitage, the motives of martyrdom and temptation) are realized. The ideological and thematic unity of the collection, as the analysis of the works that comprise it has revealed, is organized by two themes — the Beloberezhskaya hermitage as “the house of the Mother of God” and “the second Jordan.” The sources of the patericon were archival materials and publications in magazines of religious and moral content (“Kormchiy,” “Emotional Reading,” “Wanderer”). It was also established that the Paterik was compiled between 1894 and 1905, but it is not yet possible to name its compiler.
ОСОБЛИВОСТІ СОЦІАЛЬНОЇ РОБОТИ РЕЛІГІЙНИХ ОРГАНІЗАЦІЙ: СОЦІАЛЬНО-ФІЛОСОФСЬКИЙ АНАЛІЗ
Authors: Panko Oksana
Published: January 2023

Аналізуються сучасні суспільно-релігійні відносини, характерні риси ситуації постсекуляризації, яка передбачає повернення релігії у публічну сферу, збільшення впливу релігійних організацій на суспільний дискурс та практику, зокрема у реалізації соціальних ініціатив. Актуалізується важливість діалогу на засадах толерантності між різними культурними середовищами, необхідність визнання соціального служіння релігійних організацій. Розглядаються важливі виклики та завдання, які постають перед ними в Україні у сфері соціальної роботи.
Borderline personality disorder in ICD-11 and DSM-5 – the relational nature of the criteria for the disorder
Authors:   Akademia Ignatianum w Krakowie, Kraków, Polska, Krzysztof-Świderska Agnieszka , Małek Dominika ,   Akademia Ignatianum w Krakowie, Kraków, Polska
Published: January 2023

The paper illustrates the relational nature of the psychiatric category of borderline personality disorders based on the analysis of symptomatic criteria set out in the International Classification of Diseases and Related Health Problems, 11th Revision (ICD-11) issued by the World Health Organization (WHO), as well as the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) developed by the American Psychiatric Association (APA). We point to the appreciation of the relational nature of the phenomenon, which is noticeable already in a very cursory analysis, in the latest WHO and APA classification systems. The clinical manifestations of these criteria seem not only to be interconnected, but also to result from one another, suggesting a fundamentally structural nature of the phenomenon. All the described difficulties relate to interpersonal relationships – both in terms of the direct causes of disfunctions and long-term family and social consequences. This particularly applies to the borderlinetype emotionally unstable personality disorder, which is inseparably linked to emotional volatility and instability, and which is difficult to define using criteria in a way that does not give rise to diagnostic challenges. Therefore, we draw attention to difficulties with relationships, which are an important diagnostic criterion. Both ICD-11 and DSM-5 contain separate diagnostic categories for relationship problems, which, as it turns out, not necessarily coexist with other disorders. Linking relationship pathology with personality disorders may be of great importance for establishing the correct diagnosis and therefore choosing an appropriate treatment strategy.