bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Table S1 from The Transcription Factor AP4 Promotes Oncogenic Phenotypes and Cisplatin Resistance by Regulating LAPTM4B Expression
Authors: Wang Lu , Meng Yue , Xu Jian-Jun , Zhang Qing-Yun
Published: April 2023

Supplementary Table S1 shows the sequences for PCR primers and shRNA/siRNAs used in the study.
Supplementary Figure 2 from Mitotically-Associated lncRNA (MANCR) Affects Genomic Stability and Cell Division in Aggressive Breast Cancer
Authors: Tracy Kirsten M. , Tye Coralee E. , Ghule Prachi N. , Malaby Heidi L.H. , Stumpff Jason , Stein Janet L. , Stein Gary S. , Lian Jane B.
Published: April 2023

Validation of expressed genes from RNA-seq.
Supplementary table from PI3K Positively Regulates YAP and TAZ in Mammary Tumorigenesis Through Multiple Signaling Pathways
Authors: Zhao Yulei , Montminy Tess , Azad Taha , Lightbody Elizabeth , Hao Yawei , SenGupta Sandip , Asselin Eric , Nicol Christopher , Yang Xiaolong
Published: April 2023

supplementary table showing the correlation between PI3K and YAP/TAZ in Breast cancers.
Supplementary Figures S1 - S7, Table S1 from The Tumor Suppressor FBW7 and the Vitamin D Receptor Are Mutual Cofactors in Protein Turnover and Transcriptional Regulation
Authors: Salehi-Tabar Reyhaneh , Memari Babak , Wong Hilary , Dimitrov Vassil , Rochel Natacha , White John H.
Published: April 2023

Supplementary Figures S1 - S7, Table S1
Supplementary Figure S7 from Hyperphosphorylation of CDH1 in Glioblastoma Cancer Stem Cells Attenuates APC/CCDH1 Activity and Pharmacologic Inhibition of APC/CCDH1/CDC20 Compromises Viability
Authors: De Kuntal , Grubb Treg M. , Zalenski Abigail A. , Pfaff Kayla E. , Pal Debjani , Majumder Shubhra , Summers Matthew K. , Venere Monica
Published: April 2023

Sustained impact on mitotic abnormalities following drug treatment
Supplementary Figure S3 from Hyperphosphorylation of CDH1 in Glioblastoma Cancer Stem Cells Attenuates APC/CCDH1 Activity and Pharmacologic Inhibition of APC/CCDH1/CDC20 Compromises Viability
Authors: De Kuntal , Grubb Treg M. , Zalenski Abigail A. , Pfaff Kayla E. , Pal Debjani , Majumder Shubhra , Summers Matthew K. , Venere Monica
Published: April 2023

Dose response curves for proTAME and apcin in CSCs and NSTCs
Figure S1, Figure S2, Figure S4, Table S1, Table S2, Table S3 from Differential Effects of Clinically Relevant N- versus C-Terminal Truncating CDKN1A Mutations on Cisplatin Sensitivity in Bladder Cancer
Authors: Sikder Rahmat K. , Ellithi Moataz , Uzzo Robert N. , Weader David J. , Metz Alexander L. , Behbahani Ali , McKenzie Erica R. , El-Deiry Wafik S. , Abbosh Philip H.
Published: April 2023

Figure S1. A. sg12 successfully edited the CDKN1A gene in SW780 with high efficiency; chromatogram shows deletion of an adenine (A). B. Histograms from TIDE analysis of single-cell clones showed that the clones have largely homogeneous populations. Figure S2. Cisplatin sensitivity was assessed in SW780 CRISPR clones 24h after a 3h pulse dose. Increased PARP cleavage (a marker of apoptosis) was observed in three p21-deficient sg12 clones compared to sgGFP. Figure S3: see separate document. Figure S4. TCC cell lines harboring p53 mutations differentially regulate p21 after cisplatin treatment (10 µM 3-hour pulse dose) Table S1: Primary antibodies used Table S2: Secondary antibodies used Table S3: sgRNA and flanking primer sequences
Table S4 from Transcriptome-wide Landscape of Pre-mRNA Alternative Splicing Associated with Metastatic Colonization
Authors: Lu Zhi-xiang , Huang Qin , Park Juw Won , Shen Shihao , Lin Lan , Tokheim Collin J. , Henry Michael D. , Xing Yi
Published: April 2023

Table S4. Enriched GO terms of differentially spliced genes
Table S3 from Transcriptome-wide Landscape of Pre-mRNA Alternative Splicing Associated with Metastatic Colonization
Authors: Lu Zhi-xiang , Huang Qin , Park Juw Won , Shen Shihao , Lin Lan , Tokheim Collin J. , Henry Michael D. , Xing Yi
Published: April 2023

Table S3. Consensus binding sites of RNA binding proteins
Table S2 from Transcriptome-wide Landscape of Pre-mRNA Alternative Splicing Associated with Metastatic Colonization
Authors: Lu Zhi-xiang , Huang Qin , Park Juw Won , Shen Shihao , Lin Lan , Tokheim Collin J. , Henry Michael D. , Xing Yi
Published: April 2023

Table S2. Differential AS events between PC-3E and GS689.Li
Data Supplement from The lncRNA PCAT29 Inhibits Oncogenic Phenotypes in Prostate Cancer
Authors: Malik Rohit , Patel Lalit , Prensner John R. , Shi Yang , Iyer Matthew K. , Subramaniyan Shruthi , Carley Alexander , Niknafs Yashar S. , Sahu Anirban , Han Sumin , Ma Teng , Liu Meilan , Asangani Irfan A. , Jing Xiaojun , Cao Xuhong , Dhanasekaran Saravana M. , Robinson Dan R. , Feng Felix Y. , Chinnaiyan Arul M.
Published: April 2023

Supplementary Table S2. Positive and negative correlations.
Supplementary Table S2 from Salt-Inducible Kinase 2 Regulates Mitotic Progression and Transcription in Prostate Cancer
Authors: Bon Hélène , Wadhwa Karan , Schreiner Alexander , Osborne Michelle , Carroll Thomas , Ramos-Montoya Antonio , Ross-Adams Helen , Visser Matthieu , Hoffmann Ralf , Ahmed Ahmed Ashour , Neal David E. , Mills Ian G.
Published: April 2023

Supplementary Table S2. Detailed lists of differentially expressed genes (DEG) up- or down-regulated after treatment with Forskolin (Forsk.), over-expression of wild-type SIK2 or kinase-dead SIK2 (KI) and SIK2 knock-down (SIK2si). The number of DEG in each list is indicated.
Data Supplement from The lncRNA PCAT29 Inhibits Oncogenic Phenotypes in Prostate Cancer
Authors: Malik Rohit , Patel Lalit , Prensner John R. , Shi Yang , Iyer Matthew K. , Subramaniyan Shruthi , Carley Alexander , Niknafs Yashar S. , Sahu Anirban , Han Sumin , Ma Teng , Liu Meilan , Asangani Irfan A. , Jing Xiaojun , Cao Xuhong , Dhanasekaran Saravana M. , Robinson Dan R. , Feng Felix Y. , Chinnaiyan Arul M.
Published: April 2023

Supplementary Figure 2. Expression of PCAT29 in LNCaP cells.
Supplementary Table S1 from Salt-Inducible Kinase 2 Regulates Mitotic Progression and Transcription in Prostate Cancer
Authors: Bon Hélène , Wadhwa Karan , Schreiner Alexander , Osborne Michelle , Carroll Thomas , Ramos-Montoya Antonio , Ross-Adams Helen , Visser Matthieu , Hoffmann Ralf , Ahmed Ahmed Ashour , Neal David E. , Mills Ian G.
Published: April 2023

Supplementary Table S1. qRT-PCR primer sequences. When primer sequences were not from published studies, they were designed using Integrated DNA Technologies software.
Supplementary Figure 1 from Salt-Inducible Kinase 2 Regulates Mitotic Progression and Transcription in Prostate Cancer
Authors: Bon Hélène , Wadhwa Karan , Schreiner Alexander , Osborne Michelle , Carroll Thomas , Ramos-Montoya Antonio , Ross-Adams Helen , Visser Matthieu , Hoffmann Ralf , Ahmed Ahmed Ashour , Neal David E. , Mills Ian G.
Published: April 2023

Supplementary Figure 1 (Relates to Figure 2) - Kinase-dead SIK2 and SIK2 knock-down reduce proliferation of LNCaP cells.
Supplemental Figure 3 from lincRNA-RoR and miR-145 Regulate Invasion in Triple-Negative Breast Cancer via Targeting ARF6
Authors: Eades Gabriel , Wolfson Benjamin , Zhang Yongshu , Li Qinglin , Yao Yuan , Zhou Qun
Published: April 2023

Supplemental Figure 3. lincRNA-ROR localization using MS2 binding assay. MCF10A cells were transfected with MS2-GFP (containg nuclear localization signal) alone or with MS2-GFP and ROR-MS2 (containing 24 MS2 binding sites). Cytoplasmic localization of lincRNA-ROR is evidenced by retention of GFP signal in the cytoplasm.
Supplementary Figures 1-3 from EphB1 Suppression in Acute Myelogenous Leukemia: Regulating the DNA Damage Control System
Authors: Kampen K.R. , Scherpen F.J.G. , Garcia-Manero G. , Yang H. , Kaspers G.J.L. , Cloos J. , Zwaan C.M. , van den Heuvel-Eibrink M.M. , Kornblau S.M. , De Bont E.S.J.M.
Published: April 2023

Supplementary Figures 1-3. Figure S1. EfnB1 stimulated AML cells under different conditions. Figure S2. EphB1 suppression in pediatric AML. Figure S3. EphB1 promoter methylation in cancer.
Supplementary Methods, Figures 1 - 7 from Base Excision Repair Defects Invoke Hypersensitivity to PARP Inhibition
Authors: Horton Julie K. , Stefanick Donna F. , Prasad Rajendra , Gassman Natalie R. , Kedar Padmini S. , Wilson Samuel H.
Published: April 2023

PDF file - 422KB, S1. Cell survival as measured by a clonogenic assay. S2. BRCT I domain of XRCC1. S3. Characterization of cell lines by western blotting. S4. Characterization of full-length wild-type XRCC1 and L360R mutant XRCC1 mouse proteins. S5. Inhibitory effect of olaparib (O) or veliparib (V) (10 mM) on PAR accumulation in MMS-treated (10 mM for 20 min at 4 degrees C) wild-type (red) and pol beta null cells (gray). S6. Effect of PARPi on sensitivity of wild-type (16.3, closed red symbols) and pol beta null (19.4, open black symbols) cells to MMS. S7. Sensitivity of pol beta- and XRCC1-deficient cell lines to olaparib and veliparib.
Visual Overview from Systemic Ablation of MMP-9 Triggers Invasive Growth and Metastasis of Pancreatic Cancer via Deregulation of IL6 Expression in the Bone Marrow
Authors: Grünwald Barbara , Vandooren Jennifer , Gerg Michael , Ahomaa Kaarin , Hunger Annique , Berchtold Sonja , Akbareian Sophia , Schaten Susanne , Knolle Percy , Edwards Dylan R. , Opdenakker Ghislain , Krüger Achim
Published: April 2023

Visual Overview
Supplementary Table S1 from AGO2 Mediates MYC mRNA Stability in Hepatocellular Carcinoma
Authors: Zhang Kai , Pomyen Yotsawat , Barry Anna E. , Martin Sean P. , Khatib Subreen , Knight Lucy , Forgues Marshonna , Dominguez Dana A. , Parhar Ravinder , Shah Ashesh P. , Bodzin Adam S. , Wang Xin Wei , Dang Hien
Published: April 2023

Supplemental Table S1. Correlation between differentially expressed miRNAs (DEmiRNAs) and differentially expressed mRNAs (DEmRNAs) in the TCGA dataset.
Supplementary Figure S2 from Systemic Ablation of MMP-9 Triggers Invasive Growth and Metastasis of Pancreatic Cancer via Deregulation of IL6 Expression in the Bone Marrow
Authors: Grünwald Barbara , Vandooren Jennifer , Gerg Michael , Ahomaa Kaarin , Hunger Annique , Berchtold Sonja , Akbareian Sophia , Schaten Susanne , Knolle Percy , Edwards Dylan R. , Opdenakker Ghislain , Krüger Achim
Published: April 2023

Knock-down of MMP-9 did not promote invasive growth of Panc02 pancreatic cancer cells in vitro.
Supplementary Figures S1-S6 and Immunoblots from AGO2 Mediates MYC mRNA Stability in Hepatocellular Carcinoma
Authors: Zhang Kai , Pomyen Yotsawat , Barry Anna E. , Martin Sean P. , Khatib Subreen , Knight Lucy , Forgues Marshonna , Dominguez Dana A. , Parhar Ravinder , Shah Ashesh P. , Bodzin Adam S. , Wang Xin Wei , Dang Hien
Published: April 2023

Supplementary Figures S1-S6 and Immunoblots
Supplementary Figure Legends for S1 - S6 from AGO2 Mediates MYC mRNA Stability in Hepatocellular Carcinoma
Authors: Zhang Kai , Pomyen Yotsawat , Barry Anna E. , Martin Sean P. , Khatib Subreen , Knight Lucy , Forgues Marshonna , Dominguez Dana A. , Parhar Ravinder , Shah Ashesh P. , Bodzin Adam S. , Wang Xin Wei , Dang Hien
Published: April 2023

S1. AGO2 regulates that mRNA transcriptome in hepatocellular carcinoma (HCC). S2. Characterization of AGO2 levels in HCC cell lines. S3. AGO2 is important for HCC progression. S4. AGO2 driven HCCs are enriched with MYC signaling. S5. AGO2 interacts with MYC transcript. S6. CRISPR/Cas9 genome editing of DICER1 in Huh1 cells.
Supplementary Figure Legends from Systemic Ablation of MMP-9 Triggers Invasive Growth and Metastasis of Pancreatic Cancer via Deregulation of IL6 Expression in the Bone Marrow
Authors: Grünwald Barbara , Vandooren Jennifer , Gerg Michael , Ahomaa Kaarin , Hunger Annique , Berchtold Sonja , Akbareian Sophia , Schaten Susanne , Knolle Percy , Edwards Dylan R. , Opdenakker Ghislain , Krüger Achim
Published: April 2023

Supplementary Figure Legends
Data Supplement from The Lipid Kinase PI4KIIIβ Is Highly Expressed in Breast Tumors and Activates Akt in Cooperation with Rab11a
Authors: Morrow Anne A. , Alipour Mohsen Amir , Bridges Dave , Yao Zemin , Saltiel Alan R. , Lee Jonathan M.
Published: April 2023

Supplementary Figure 3
Supplementary Data from Circular RNA hsa_circ_0014130 Inhibits Apoptosis in Non–Small Cell Lung Cancer by Sponging miR-136-5p and Upregulating BCL2
Authors: Geng Ying , Bao Yongxia , Deng Lili , Su Dongju , Zheng Hongyan , Zhang Wei
Published: April 2023

Supplementary Figure legend
Supplemental Figure Legend from Gas1 Inhibits Metastatic and Metabolic Phenotypes in Colorectal Carcinoma
Authors: Li Qingguo , Qin Yi , Wei Ping , Lian Peng , Li Yaqi , Xu Ye , Li Xinxiang , Li Dawei , Cai Sanjun
Published: April 2023

Supplemental Figure 1
Supplementary Tables 1-3, Figures 1-2 from Differential Effects of Tyrosine Kinase Inhibitors on Normal and Oncogenic EGFR Signaling and Downstream Effectors
Authors: Kim Youngjoo , Apetri Mihaela , Luo BeiBei , Settleman Jeffrey E. , Anderson Karen S.
Published: April 2023

Supplementary Tables 1-3, Figures 1-2. Table 1. IC50 values (μM) of gefitinib (A) and erlotinib (B) toward wild type and L858R EGFR. Table 2. IC50 (μM) of gefitinib (A) and erlotinib (B) toward downstream signaling proteins in 32D cells. Table 3. IC50 (μM) of gefitinib (A) and erlotinib (B) toward downstream signaling proteins in cancer cell lines. Figure 1. (A) Effect of gefitinib on activation of EGFR signaling proteins in 32D cells. (B) Effect of erlotinib on activation of EGFR signaling proteins in 32D cells. Figure 2. (A) Effect of gefitinib on activation of EGFR signaling proteins in cancer cells. (B) Effect of erlotinib on activation of EGFR signaling proteins in cancer cells.
Table S4 from Distinct Transcriptional Changes and Epithelial–Stromal Interactions Are Altered in Early-Stage Colon Cancer Development
Authors: Mo Allen , Jackson Stephen , Varma Kamini , Carpino Alan , Giardina Charles , Devers Thomas J. , Rosenberg Daniel W.
Published: April 2023

Differentially expressed genes between KRAS mutant and BRAF mutant ACF epithelium.
Figure S1 from PTPN3 Inhibits the Growth and Metastasis of Clear Cell Renal Cell Carcinoma via Inhibition of PI3K/AKT Signaling
Authors: Peng Xing-Si , Yang Jun-Ping , Qiang Yuan-Yuan , Sun Rui , Cao Yun , Zheng Li-Sheng , Peng Li-Xia , Lang Yan-Hong , Mei Yan , Li Chang-Zhi , Meng Dong-Fang , Liu Zhi-Jie , Wang Ming-Dian , Zhou Fang-Jian , Huang Bi-Jun , Qian Chao-Nan
Published: April 2023

PTPN3 mRNA was significantly lower in all tumor samples than in paired normal tissues of the TCGA database. a-c. http://gepia.cancer-pku.cn/detail.php?gene=PTPN3
Supplementary Figure 6 from Targeting MPS1 Enhances Radiosensitization of Human Glioblastoma by Modulating DNA Repair Proteins
Authors: Maachani Uday Bhanu , Kramp Tamalee , Hanson Ryan , Zhao Shuping , Celiku Orieta , Shankavaram Uma , Colombo Riccardo , Caplen Natasha J. , Camphausen Kevin , Tandle Anita
Published: April 2023

Supplementary Figure 6. Kaplan-Meier curve analysis examining MPS1 expression (red- high expression, black- low expression) and overall survival association in 1115 breast (A) and 1405 lung (B) cancer patients using univariate analysis using KM-Plotter (www.kmplot.com).
Supplementary Figure 3 from Targeting MPS1 Enhances Radiosensitization of Human Glioblastoma by Modulating DNA Repair Proteins
Authors: Maachani Uday Bhanu , Kramp Tamalee , Hanson Ryan , Zhao Shuping , Celiku Orieta , Shankavaram Uma , Colombo Riccardo , Caplen Natasha J. , Camphausen Kevin , Tandle Anita
Published: April 2023

Supplementary Figure 3. Western blot analysis of pDNAPK and DNAPK from 2.5 uM NMS-P715 treated and irradiated (4 Gy) U251 cells.
Figure S6 from 27-Hydroxycholesterol Impairs Plasma Membrane Lipid Raft Signaling as Evidenced by Inhibition of IL6–JAK–STAT3 Signaling in Prostate Cancer Cells
Authors: Dambal Shweta , Alfaqih Mahmoud , Sanders Sergio , Maravilla Erick , Ramirez-Torres Adela , Galvan Gloria C. , Reis-Sobreiro Mariana , Rotinen Mirja , Driver Lucy M. , Behrove Matthew S. , Talisman Tijana Jovanovic , Yoon Junhee , You Sungyong , Turkson James , Chi Jen-Tsan , Freeman Michael R. , Macias Everardo , Freedland Stephen J.
Published: April 2023

Primer Sequences
Figure S3 from 27-Hydroxycholesterol Impairs Plasma Membrane Lipid Raft Signaling as Evidenced by Inhibition of IL6–JAK–STAT3 Signaling in Prostate Cancer Cells
Authors: Dambal Shweta , Alfaqih Mahmoud , Sanders Sergio , Maravilla Erick , Ramirez-Torres Adela , Galvan Gloria C. , Reis-Sobreiro Mariana , Rotinen Mirja , Driver Lucy M. , Behrove Matthew S. , Talisman Tijana Jovanovic , Yoon Junhee , You Sungyong , Turkson James , Chi Jen-Tsan , Freeman Michael R. , Macias Everardo , Freedland Stephen J.
Published: April 2023

PC3 and DU145 dose finding studies for STAT3 inhibitors
Figure S1 from 27-Hydroxycholesterol Impairs Plasma Membrane Lipid Raft Signaling as Evidenced by Inhibition of IL6–JAK–STAT3 Signaling in Prostate Cancer Cells
Authors: Dambal Shweta , Alfaqih Mahmoud , Sanders Sergio , Maravilla Erick , Ramirez-Torres Adela , Galvan Gloria C. , Reis-Sobreiro Mariana , Rotinen Mirja , Driver Lucy M. , Behrove Matthew S. , Talisman Tijana Jovanovic , Yoon Junhee , You Sungyong , Turkson James , Chi Jen-Tsan , Freeman Michael R. , Macias Everardo , Freedland Stephen J.
Published: April 2023

The figures depicts the optimization of PFO-D4 cholesterol probe
Figure S5 from DNA Replication Stress Induced by Trifluridine Determines Tumor Cell Fate According to p53 Status
Authors: Kataoka Yuki , Iimori Makoto , Fujisawa Ryo , Morikawa-Ichinose Tomomi , Niimi Shinichiro , Wakasa Takeshi , Saeki Hiroshi , Oki Eiji , Miura Daisuke , Tsurimoto Toshiki , Maehara Yoshihiko , Kitao Hiroyuki
Published: April 2023

Data related to Fig. 5C.
Supplementary Figure Legend from Aquaporin-9, Mediated by IGF2, Suppresses Liver Cancer Stem Cell Properties via Augmenting ROS/β-Catenin/FOXO3a Signaling
Authors: Zheng Xi , Li Chuanfei , Yu Keqi , Shi Shasha , Chen Hongyu , Qian Yanzhi , Mei Zhechuan
Published: April 2023

Supplementary Figure Legend 1.
Figure S3 legend from DNA Replication Stress Induced by Trifluridine Determines Tumor Cell Fate According to p53 Status
Authors: Kataoka Yuki , Iimori Makoto , Fujisawa Ryo , Morikawa-Ichinose Tomomi , Niimi Shinichiro , Wakasa Takeshi , Saeki Hiroshi , Oki Eiji , Miura Daisuke , Tsurimoto Toshiki , Maehara Yoshihiko , Kitao Hiroyuki
Published: April 2023

The legend of Fig. S3.
Figure S1 from DNA Replication Stress Induced by Trifluridine Determines Tumor Cell Fate According to p53 Status
Authors: Kataoka Yuki , Iimori Makoto , Fujisawa Ryo , Morikawa-Ichinose Tomomi , Niimi Shinichiro , Wakasa Takeshi , Saeki Hiroshi , Oki Eiji , Miura Daisuke , Tsurimoto Toshiki , Maehara Yoshihiko , Kitao Hiroyuki
Published: April 2023

Data related to Fig. 1.
Supplementary Figures 1-6 from Amplification of TLK2 Induces Genomic Instability via Impairing the G2–M Checkpoint
Authors: Kim Jin-Ah , Anurag Meenakshi , Veeraraghavan Jamunarani , Schiff Rachel , Li Kaiyi , Wang Xiao-Song
Published: April 2023

Figure S1. Correlation of the genomic instability index and copy number breakpoint index with AURKA or PLK1 expression (RNAseq) in 1083 invasive breast cancers based on Spearman's correlation statistics. Figure S2. Association of TLK2, AURKA and PLK1 overexpression with chromosome instability (CIN) in breast cancer. Figure S3. Representative microscope images of γ-H2AX foci formation assay showing delayed DSB repair in T47D or MCF10A cells inducibly overexpressing TLK2. Figure S4. In response to irradiation (IR), TLK2 forms foci that partially co-localize with γ-H2AX foci. Figure S5. TLK2 overexpression led to reduced accumulation of G2/M phase cells in response to IR. Figure S6. The mechanisms of G2/M checkpoint signaling in response to irradiation.
Data Supplement from CD44-Mediated Adhesion to Hyaluronic Acid Contributes to Mechanosensing and Invasive Motility
Authors: Kim Yushan , Kumar Sanjay
Published: April 2023

S1. Stable lentiviral transduction of CD44-targeting shRNA into U373-MG glioblastoma cells. S2. Characterization of effects of CD44 knockdown on integrin characterization and cell viability. S3. Cells seeded on HA hydrogels functionalized with fibronectin (A-B) or laminin (CD) exhibit similar stiffness-dependence on cell spread area and cell motility as cell seeded on hydrogels with RGD peptide. S4. Adsorption of hyaluronic acid and fibronectin onto solid substrates selectively engages CD44 and integrin-based adhesions. Legend for Supplementary Movie 1.
Supplementary Table 3 from Evolution of Dermatofibrosarcoma Protuberans to DFSP-Derived Fibrosarcoma: An Event Marked by Epithelial–Mesenchymal Transition–like Process and 22q Loss
Authors: Stacchiotti Silvia , Astolfi Annalisa , Gronchi Alessandro , Fontana Andrea , Pantaleo Maria A. , Negri Tiziana , Brenca Monica , Tazzari Marcella , Urbini Milena , Indio Valentina , Colombo Chiara , Radaelli Stefano , Brich Silvia , Dei Tos Angelo P. , Casali Paolo G. , Castelli Chiara , Dagrada Gian Paolo , Pilotti Silvana , Maestro Roberta
Published: April 2023

Additional fusion genes identified in FS-DFSP.
Supplementary Figure 5 from Evolution of Dermatofibrosarcoma Protuberans to DFSP-Derived Fibrosarcoma: An Event Marked by Epithelial–Mesenchymal Transition–like Process and 22q Loss
Authors: Stacchiotti Silvia , Astolfi Annalisa , Gronchi Alessandro , Fontana Andrea , Pantaleo Maria A. , Negri Tiziana , Brenca Monica , Tazzari Marcella , Urbini Milena , Indio Valentina , Colombo Chiara , Radaelli Stefano , Brich Silvia , Dei Tos Angelo P. , Casali Paolo G. , Castelli Chiara , Dagrada Gian Paolo , Pilotti Silvana , Maestro Roberta
Published: April 2023

The imaging gallery demonstrates that the number of EZH2 immunolabelled nuclei parallels those decorated by Ki-67 in both FS-DFSP (left) and DFSP (right) cases.
Supplementary Figure Legends from Hepatitis B Virus X Protein Induces RHAMM-Dependent Motility in Hepatocellular Carcinoma Cells via PI3K–Akt–Oct-1 Signaling
Authors: Liu Yu-Chin , Lu Li-Feng , Li Chia-Jung , Sun Nian-Kang , Guo Jing-You , Huang Ya-Hui , Yeh Chau-Ting , Chao Chuck C.-K.
Published: April 2023

Supplementary Figure Legends
Supplementary Figure 2 from Evolution of Dermatofibrosarcoma Protuberans to DFSP-Derived Fibrosarcoma: An Event Marked by Epithelial–Mesenchymal Transition–like Process and 22q Loss
Authors: Stacchiotti Silvia , Astolfi Annalisa , Gronchi Alessandro , Fontana Andrea , Pantaleo Maria A. , Negri Tiziana , Brenca Monica , Tazzari Marcella , Urbini Milena , Indio Valentina , Colombo Chiara , Radaelli Stefano , Brich Silvia , Dei Tos Angelo P. , Casali Paolo G. , Castelli Chiara , Dagrada Gian Paolo , Pilotti Silvana , Maestro Roberta
Published: April 2023

Sections from case D6, exhibiting low- (left) and high-grade (right) components, immunolabelled with antibodies against SNAI2/SLUG (A), TWIST1(B) and ZEB1 (C). The photograph show a significant increase of immunolabelled nuclei in the more cellular high-grade area.
Supplementary Video 2 from CD44 Regulates Formation of Spheroids and Controls Organ-Specific Metastatic Colonization in Epithelial Ovarian Carcinoma
Authors: Sacks Suarez Joelle , Gurler Main Hilal , Muralidhar Goda G. , Elfituri Osama , Xu Hao-Liang , Kajdacsy-Balla Andre A. , Barbolina Maria V.
Published: April 2023

Adhesion of parental ES2 cells to solid supports.
Supplementary Figure legends and Methods from CD44 Regulates Formation of Spheroids and Controls Organ-Specific Metastatic Colonization in Epithelial Ovarian Carcinoma
Authors: Sacks Suarez Joelle , Gurler Main Hilal , Muralidhar Goda G. , Elfituri Osama , Xu Hao-Liang , Kajdacsy-Balla Andre A. , Barbolina Maria V.
Published: April 2023

Supplementary figure legends and methods file
Supplementary Materials and Methods from miR-29a Is Repressed by MYC in Pancreatic Cancer and Its Restoration Drives Tumor-Suppressive Effects via Downregulation of LOXL2
Authors: Dey Shatovisha , Kwon Jason J. , Liu Sheng , Hodge Gabriel A. , Taleb Solaema , Zimmers Teresa A. , Wan Jun , Kota Janaiah
Published: April 2023

Supplementary Methods
Figure S7 from CD44 Regulates Formation of Spheroids and Controls Organ-Specific Metastatic Colonization in Epithelial Ovarian Carcinoma
Authors: Sacks Suarez Joelle , Gurler Main Hilal , Muralidhar Goda G. , Elfituri Osama , Xu Hao-Liang , Kajdacsy-Balla Andre A. , Barbolina Maria V.
Published: April 2023

SUPPLEMENTARY FIGURE 7. CD44 contributes to spheroid adhesion to mesothelial monolayer of LP-3 cells.
Supplemental Figures Collated from The Role of Nitric Oxide Synthase Uncoupling in Tumor Progression
Authors: Rabender Christopher S. , Alam Asim , Sundaresan Gobalakrishnan , Cardnell Robert J. , Yakovlev Vasily A. , Mukhopadhyay Nitai D. , Graves Paul , Zweit Jamal , Mikkelsen Ross B.
Published: April 2023

Supplemental Figures Collated: All four supplemental data figures combined with description
Supplemental Figure 1 from The Role of Nitric Oxide Synthase Uncoupling in Tumor Progression
Authors: Rabender Christopher S. , Alam Asim , Sundaresan Gobalakrishnan , Cardnell Robert J. , Yakovlev Vasily A. , Mukhopadhyay Nitai D. , Graves Paul , Zweit Jamal , Mikkelsen Ross B.
Published: April 2023

Supplemental Figure 1: shows an example of the HPLC technique used to measure BH4:BH2 throughout the manuscript.
Fig. S1. Negative controls for IHC staining of CX3CR1 in human tissues. from Novel Small-Molecule CX3CR1 Antagonist Impairs Metastatic Seeding and Colonization of Breast Cancer Cells
Authors: Shen Fei , Zhang Yun , Jernigan Danielle L. , Feng Xin , Yan Jie , Garcia Fernando U. , Meucci Olimpia , Salvino Joseph M. , Fatatis Alessandro
Published: April 2023

Tissue sections of primary breast adenocarcinoma showed a strong immunoreactivity to the CX3CR1 antibody (left); the staining was completely abolished by pre-incubating the antibody with a blocking peptide prior to incubation with the tissue sections (right). Magnification: 200x.
Figure S2 from Extracellular ATP a New Player in Cancer Metabolism: NSCLC Cells Internalize ATP In Vitro and In Vivo Using Multiple Endocytic Mechanisms
Authors: Qian Yanrong , Wang Xuan , Li Yunsheng , Cao Yanyang , Chen Xiaozhuo
Published: April 2023

Fig. S2. Extracellular ATP induced elevation of intracellular ATP levels and the Internalized ATP is associated with cytoplasmic portion of cancer cells.
Figure S1 from Extracellular ATP a New Player in Cancer Metabolism: NSCLC Cells Internalize ATP In Vitro and In Vivo Using Multiple Endocytic Mechanisms
Authors: Qian Yanrong , Wang Xuan , Li Yunsheng , Cao Yanyang , Chen Xiaozhuo
Published: April 2023

Fig. S1. Quantification of internalized HMWFD or NHF-ATP in A549 cells.
Supplementary Figures and Legends 1-9, Supplementary Table 1 from Telomere DNA Damage Signaling Regulates Prostate Cancer Tumorigenesis
Authors: Wu Jianchun , Crowe David L.
Published: April 2023

Fig. S1. Telomere DNA damage is significantly increased in human prostate cancer. Fig. S2. Relative expression of TRF2 and p53 mRNAs in prostate glands from 8 week old K14Cre;TRF2+/+;p53+/+, K14Cre;TRF2f/f;p53+/+, and K14Cre;TRF2f/f;p53f/f mice is shown by qRT-PCR. Fig. S3. Increased senescence, decreased proliferation, and increased cell death in K14Cre;TRF2f/f;p53+/+ prostate epithelium. Fig. S4. Quantitation of SAHF+ cells in prostate glands from K14Cre;TRF2+/+;p53+/+, K14Cre;TRF2f/f;p53+/+, and K14Cre;TRF2f/f;p53f/f mice. Fig. S5. Defective secretion in K14Cre;TRF2f/f;p53+/+ prostate glands. Fig. S6. Telomere DNA damage signaling in K14Cre;TRF2f/f;p53+/+ prostate epithelium. Fig. S7. (A) Quantitation of 53BP1+ cells in prostate glands from K14Cre;TRF2+/+;p53+/+, K14Cre;TRF2f/f;p53+/+, and K14Cre;TRF2f/f;p53f/f mice. Fig. S8. Increased proliferation and reduced differentiation of K14Cre;TRF2f/f;TAg prostate tumors. Fig. S9. Decreased proliferation, increased AR+ differentiation, and apoptosis in K14Cre;TRF2f/f;Terc-/-;TAg prostate glands. Supplementary Table 1. Telomere DNA damage and tumor staging
Data Supplement from Hypoxia Provokes Base Excision Repair Changes and a Repair-Deficient, Mutator Phenotype in Colorectal Cancer Cells
Authors: Chan Norman , Ali Mohsin , McCallum Gordon P. , Kumareswaran Ramya , Koritzinsky Marianne , Wouters Bradly G. , Wells Peter G. , Gallinger Steven , Bristow Robert G.
Published: April 2023

Supplemental Figure Legends
Data Supplement from Hypoxia Provokes Base Excision Repair Changes and a Repair-Deficient, Mutator Phenotype in Colorectal Cancer Cells
Authors: Chan Norman , Ali Mohsin , McCallum Gordon P. , Kumareswaran Ramya , Koritzinsky Marianne , Wouters Bradly G. , Wells Peter G. , Gallinger Steven , Bristow Robert G.
Published: April 2023

Supplementary Figure 2. (A) Schematic of MYH DNA glycosylase activity on the 39-mer duplex DNA substrate containing A:GO mismatch. (B) Schematic of OGG1 DNA glycosylase activity on the 49-mer duplex DNA substrate containing hydroxyguainine [GO] opposite cytosine [C].
Supplementary Table 1 from LEF1 Targeting EMT in Prostate Cancer Invasion Is Regulated by miR-34a
Authors: Liang Jiaqian , Li Yirong , Daniels Garrett , Sfanos Karen , De Marzo Angelo , Wei Jianjun , Li Xin , Chen Wenqiang , Wang Jinhua , Zhong Xuelin , Melamed Jonathan , Zhao Jun , Lee Peng
Published: April 2023

Supplementary Table 1. Clinical Characteristics of Patient Samples Used in the Study
Supplemental Table 2 from Identification of TRIML2, a Novel p53 Target, that Enhances p53 SUMOylation and Regulates the Transactivation of Proapoptotic Genes
Authors: Kung Che-Pei , Khaku Sakina , Jennis Matthew , Zhou Yan , Murphy Maureen E.
Published: April 2023

Table S2. Primers used for qRT-PCR and ChIP assays.
Supplemental Table 1 from Identification of TRIML2, a Novel p53 Target, that Enhances p53 SUMOylation and Regulates the Transactivation of Proapoptotic Genes
Authors: Kung Che-Pei , Khaku Sakina , Jennis Matthew , Zhou Yan , Murphy Maureen E.
Published: April 2023

Table S1. Genes specifically upregulated by P72 or R72 p53 in microarray analysis.
Figure S1 from DNA Methylome Analyses Implicate Fallopian Tube Epithelia as the Origin for High-Grade Serous Ovarian Cancer
Authors: Klinkebiel David , Zhang Wa , Akers Stacey N. , Odunsi Kunle , Karpf Adam R.
Published: April 2023

Karpf 450K Pearson correlation coefficient analysis.
Supplemental Figure legends from Identification of TRIML2, a Novel p53 Target, that Enhances p53 SUMOylation and Regulates the Transactivation of Proapoptotic Genes
Authors: Kung Che-Pei , Khaku Sakina , Jennis Matthew , Zhou Yan , Murphy Maureen E.
Published: April 2023

Supplemental Figure legends
Supplementary Figure 4 from Decreased eIF3e Expression Can Mediate Epithelial-to-Mesenchymal Transition through Activation of the TGFβ Signaling Pathway
Authors: Desnoyers Guillaume , Frost Laura D. , Courteau Lynn , Wall Michael L. , Lewis Stephen M.
Published: April 2023

Supplementary Figure 4 - A549 cells harboring an eIF3e targeting shRNA (205) were treated with the TGF-β signaling inhibitor SB431542 at a concentration of 10 μM for 48h, after which total RNA was extracted and the expression levels of CDH1, CDH2, VIM and TGFBI were measured by qRT2 PCR. Expression levels are normalized to HPRT expression levels and the graph is a summary of at least three independent experiments.
Supplementary Figure 3 from Decreased eIF3e Expression Can Mediate Epithelial-to-Mesenchymal Transition through Activation of the TGFβ Signaling Pathway
Authors: Desnoyers Guillaume , Frost Laura D. , Courteau Lynn , Wall Michael L. , Lewis Stephen M.
Published: April 2023

Supplementary Figure 3- Translation of the TGFB1 mRNA is maintained in A549 205 cells. Polysomal and non-polysomal mRNAs were harvested from A549 and MCF-10A cells harboring a non15 silencing control shRNA (scr) or the eIF3e shRNA (205). Each gradient fraction was collected and subsequently used as a template for qRT-PCR analysis of the TGFB1 mRNA. The abundance of mRNA in each fraction is plotted as a percentage of total mRNA. Graphs are representative of at least three independent experiments.
Supplemental Figure 4 from Identification of TRIML2, a Novel p53 Target, that Enhances p53 SUMOylation and Regulates the Transactivation of Proapoptotic Genes
Authors: Kung Che-Pei , Khaku Sakina , Jennis Matthew , Zhou Yan , Murphy Maureen E.
Published: April 2023

Figure S4. Effect of TRIML2 knockdown on p53 target gene expression.
Supplemental Figure 1 from Identification of TRIML2, a Novel p53 Target, that Enhances p53 SUMOylation and Regulates the Transactivation of Proapoptotic Genes
Authors: Kung Che-Pei , Khaku Sakina , Jennis Matthew , Zhou Yan , Murphy Maureen E.
Published: April 2023

Figure S1. Identification of differentially-regulated p53 target genes between P72 and R72 NHFs using microarray experiment.
Supplemental Figure Legends from Decreased eIF3e Expression Can Mediate Epithelial-to-Mesenchymal Transition through Activation of the TGFβ Signaling Pathway
Authors: Desnoyers Guillaume , Frost Laura D. , Courteau Lynn , Wall Michael L. , Lewis Stephen M.
Published: April 2023

Legends for supplemental figures
Supplemental Figure S1 from SIX1 Oncoprotein as a Biomarker in a Model of Hormonal Carcinogenesis and in Human Endometrial Cancer
Authors: Suen Alisa A. , Jefferson Wendy N. , Wood Charles E. , Padilla-Banks Elizabeth , Bae-Jump Victoria L. , Williams Carmen J.
Published: April 2023

Uterine abnormalities resulting from neonatal exposure to GEN or DES.
Supplementary File 4 from Targeting NAD+ Biosynthesis Overcomes Panobinostat and Bortezomib-Induced Malignant Glioma Resistance
Authors: Jane Esther P. , Premkumar Daniel R. , Thambireddy Swetha , Golbourn Brian , Agnihotri Sameer , Bertrand Kelsey C. , Mack Stephen C. , Myers Max I. , Chattopadhyay Ansuman , Taylor D. Lansing , Schurdak Mark E. , Stern Andrew M. , Pollack Ian F.
Published: April 2023

Supplemental File 4: DIPG007 Genes, SJG2 Genes, U87 Genes
Supplementary File 1 from Targeting NAD+ Biosynthesis Overcomes Panobinostat and Bortezomib-Induced Malignant Glioma Resistance
Authors: Jane Esther P. , Premkumar Daniel R. , Thambireddy Swetha , Golbourn Brian , Agnihotri Sameer , Bertrand Kelsey C. , Mack Stephen C. , Myers Max I. , Chattopadhyay Ansuman , Taylor D. Lansing , Schurdak Mark E. , Stern Andrew M. , Pollack Ian F.
Published: April 2023

Supplemental File 1: Differential Gene Expression between drug naive versus resistant/"recovery" U87 cell line
Supplementary Figure Legends from Targeting NAD+ Biosynthesis Overcomes Panobinostat and Bortezomib-Induced Malignant Glioma Resistance
Authors: Jane Esther P. , Premkumar Daniel R. , Thambireddy Swetha , Golbourn Brian , Agnihotri Sameer , Bertrand Kelsey C. , Mack Stephen C. , Myers Max I. , Chattopadhyay Ansuman , Taylor D. Lansing , Schurdak Mark E. , Stern Andrew M. , Pollack Ian F.
Published: April 2023

Supplemental Figure Legends 1-7
Supplementary Figure 6 from Targeting NAD+ Biosynthesis Overcomes Panobinostat and Bortezomib-Induced Malignant Glioma Resistance
Authors: Jane Esther P. , Premkumar Daniel R. , Thambireddy Swetha , Golbourn Brian , Agnihotri Sameer , Bertrand Kelsey C. , Mack Stephen C. , Myers Max I. , Chattopadhyay Ansuman , Taylor D. Lansing , Schurdak Mark E. , Stern Andrew M. , Pollack Ian F.
Published: April 2023

Supplemental Figure 6. A. Drug naive and panobinostat and bortezomib-resistant (P + B) U87 cells were treated with gefitinib (2 µmol/L), enzastaurin (2 µmol/L), dasatinib (0.1 µmol/L), dinaciclib (0.18 µmol/L), PI 103 (1 µmol/L), PD 0325901 (2 µmol/L), HSP 990 (0.025 µmol/L), ABT 737 (2 µmol/L), JQ 1 (2 µmol/L), TP 0903 (2 µmol/L), Bay 11-7082 (2 µmol/L), YM 155 (0.025 µmol/L), cucurbitacin-I (0.2 µmol/L), vincristine (0.01 µmol/L), vinblastine (0.01 µmol/L), taxol (0.05 µmol/L), topotecan (0.025 µmol/L), temozolomide (25 µmol/L), gemcitabine (0.25 µmol/L) and 5-fluorouracil (20 µmol/L).
Supplementary Figure 4 from Targeting NAD+ Biosynthesis Overcomes Panobinostat and Bortezomib-Induced Malignant Glioma Resistance
Authors: Jane Esther P. , Premkumar Daniel R. , Thambireddy Swetha , Golbourn Brian , Agnihotri Sameer , Bertrand Kelsey C. , Mack Stephen C. , Myers Max I. , Chattopadhyay Ansuman , Taylor D. Lansing , Schurdak Mark E. , Stern Andrew M. , Pollack Ian F.
Published: April 2023

Supplemental Figure 4. Volcano plot representing differentially expressed genes for U87 naive versus resistant cells with a minimum of a 1.5-fold change, P-value < 0.05 and FDR < 0.10 between control and A.
Supplementary Figure 3 from Targeting NAD+ Biosynthesis Overcomes Panobinostat and Bortezomib-Induced Malignant Glioma Resistance
Authors: Jane Esther P. , Premkumar Daniel R. , Thambireddy Swetha , Golbourn Brian , Agnihotri Sameer , Bertrand Kelsey C. , Mack Stephen C. , Myers Max I. , Chattopadhyay Ansuman , Taylor D. Lansing , Schurdak Mark E. , Stern Andrew M. , Pollack Ian F.
Published: April 2023

Supplemental Figure 3. Drug naive U87 or panobinostat-resistant, bortezomib-resistant, or panobinostat and bortezomib-resistant (P + B) cells were cotreated with panobinostat (25 nmol/L) plus bortezomib (2.5 nmol/L) for 24 h.
Supplementary Figure 1 from Targeting NAD+ Biosynthesis Overcomes Panobinostat and Bortezomib-Induced Malignant Glioma Resistance
Authors: Jane Esther P. , Premkumar Daniel R. , Thambireddy Swetha , Golbourn Brian , Agnihotri Sameer , Bertrand Kelsey C. , Mack Stephen C. , Myers Max I. , Chattopadhyay Ansuman , Taylor D. Lansing , Schurdak Mark E. , Stern Andrew M. , Pollack Ian F.
Published: April 2023

Supplemental Figure 1. Schematic of the approach taken to achieve drug resistance.
Table S3 from Phosphoproteomics Reveals MAPK Inhibitors Enhance MET- and EGFR-Driven AKT Signaling in KRAS-Mutant Lung Cancer
Authors: Kim Jae-Young , Welsh Eric A. , Fang Bin , Bai Yun , Kinose Fumi , Eschrich Steven A. , Koomen John M. , Haura Eric B.
Published: April 2023

Table S3. Top 10 pathways enriched by GeneGO analysis of selumetinib-regulated phosphoproteins.
Table S1 from Phosphoproteomics Reveals MAPK Inhibitors Enhance MET- and EGFR-Driven AKT Signaling in KRAS-Mutant Lung Cancer
Authors: Kim Jae-Young , Welsh Eric A. , Fang Bin , Bai Yun , Kinose Fumi , Eschrich Steven A. , Koomen John M. , Haura Eric B.
Published: April 2023

Table S1. List of phosphopeptides identified by phosphoproteomics experiments in A427 and A549 cell line treated with vehicle control (DMSO) or MEK inhibitor (selumetinib)
Supplementary Table 4 from Tumor Cell–Derived MMP3 Orchestrates Rac1b and Tissue Alterations That Promote Pancreatic Adenocarcinoma
Authors: Mehner Christine , Miller Erin , Khauv Davitte , Nassar Aziza , Oberg Ann L. , Bamlet William R. , Zhang Lizhi , Waldmann Jens , Radisky Evette S. , Crawford Howard C. , Radisky Derek C.
Published: April 2023

XLSX file - 14K, Supplemental Table 4. Gene Ontology categories enriched in transcriptional profiles of cells treated with MMP-3.
Supplementary Table 2 from Tumor Cell–Derived MMP3 Orchestrates Rac1b and Tissue Alterations That Promote Pancreatic Adenocarcinoma
Authors: Mehner Christine , Miller Erin , Khauv Davitte , Nassar Aziza , Oberg Ann L. , Bamlet William R. , Zhang Lizhi , Waldmann Jens , Radisky Evette S. , Crawford Howard C. , Radisky Derek C.
Published: April 2023

PDF file - 95K, Supplemental Table 2. Analysis of Ra.c1b polarity vs MMP3 & Rac1b Staining Intensity
Supplementary Table 1 from Autophagy Supports Breast Cancer Stem Cell Maintenance by Regulating IL6 Secretion
Authors: Maycotte Paola , Jones Kenneth L. , Goodall Megan L. , Thorburn Jacqueline , Thorburn Andrew
Published: April 2023

Supplementary Table 1. Significant genes with Q value < 0.01 in the MCF7 cell line.
supplemental figure 1 from SGK Kinase Activity in Multiple Myeloma Cells Protects against ER Stress Apoptosis via a SEK-Dependent Mechanism
Authors: Hoang Bao , Shi Yijiang , Frost Patrick J. , Mysore Veena , Bardeleben Carolyne , Lichtenstein Alan
Published: April 2023

Suppl fig 1: A) OPM2 cells transfected with empty vector (EV) wild type SGK (sgk) or phosphomimetic SGK (sgks422d) followed by immunoblot assay; B) OPM-2 cells transfected with EV (black columns) or wild type SGK (white columns) and treated with boretzomib (Bort) for 24 hrs followed by MTT assays. Data are percent survival, mean+/-SE, n=3. Apoptosis also assessed and shown above bars as mean % apoptosis, n=3; SGK-transfected cells show significant resistance (p<0.05) to all concentrations of bortezomib; C) OPM-2 cells treated for 24 hrs with thapsigargin (thaps) or tunicamycin (tun) followed by apoptosis assay. Data are percent apoptosis above control, means+/-SE, n=3. Black columns are EV-transfected OPM-2 cells and white columns are SGK-transfected cells. * denotes significant (p<0.05) decreased apoptosis vs control EV cells.
Supplementary Figure 2 from VDR Status Arbitrates the Prometastatic Effects of Tumor-Associated Macrophages
Authors: Zhang Yan , Guo Quanjun , Zhang Zhujun , Bai Nan , Liu Ze , Xiong Min , Wei Yuquan , Xiang Rong , Tan Xiaoyue
Published: April 2023

PDF file - 2087KB, Administration of 1,25(OH)2D3 protects VDR expression and decreases metastasis induced by TNF-alpha and TGF-beta1 in MCF7 cells.
Supplementary Video 1 from Urothelial Carcinoma of the Bladder Induces Endothelial Cell Activation and Hypercoagulation
Authors: John Axel , Robador José R. , Vidal-y-Sy Sabine , Houdek Pia , Wladykowski Ewa , Günes Cagatay , Bolenz Christian , Schneider Stefan W. , Bauer Alexander T. , Gorzelanny Christian
Published: April 2023

Supernatants of UROtsa cells failed to induce endothelial activation. Calcein blue labeled HUVECs (blue) were perfused with calcein red-orange labeled platelets (red) resuspended in cell culture medium conditioned by UROtsa cells.
Supplementary Methods and Materials, Figure Legend from ZBTB7A Suppresses Melanoma Metastasis by Transcriptionally Repressing MCAM
Authors: Liu Xue-Song , Genet Matthew D. , Haines Jenna E. , Mehanna Elie K. , Wu Shaowei , Chen Hung-I Harry , Chen Yidong , Qureshi Abrar A. , Han Jiali , Chen Xiang , Fisher David E. , Pandolfi Pier Paolo , Yuan Zhi-Min
Published: April 2023

Supplementary Methods and Materials, Figure Legend
Supplementary Material and Methods, Supplementary Figures 1-4, Supplementary Table 1, Supplementary Videos 1 and 2 Legends from Urothelial Carcinoma of the Bladder Induces Endothelial Cell Activation and Hypercoagulation
Authors: John Axel , Robador José R. , Vidal-y-Sy Sabine , Houdek Pia , Wladykowski Ewa , Günes Cagatay , Bolenz Christian , Schneider Stefan W. , Bauer Alexander T. , Gorzelanny Christian
Published: April 2023

S1: Schematic overview of the potential cross talk between bladder cancer cells, the endothelium and the coagulation system. S2: Expression of procoagulant factors and ability of T24 cells to produce thrombin. S3: UCB cells trigger angiogenesis. S4: VWF mediated blood vessel occlusion in peritumoral tissue.

Supplementary Table 1. Correlation of the overall patients' survival with the expression of the indicated genes.

Supplementary Video 1. Supernatants of UROtsa cells failed to induce endothelial activation.

Supplementary Video 2. Supernatants of RT4 cells induced endothelial activation.
Data Supplement from Decreased Expression of Cystathionine β-Synthase Promotes Glioma Tumorigenesis
Authors: Takano Naoharu , Sarfraz Yasmeen , Gilkes Daniele M. , Chaturvedi Pallavi , Xiang Lisha , Suematsu Makoto , Zagzag David , Semenza Gregg L.
Published: April 2023

Supplementary Figure Legends
Supplementary Materials and Methods, Supplementary Results, Supplementary Tables 1 through 3, and Supplementary Figure Legends from Cooperativity of E-cadherin and Smad4 Loss to Promote Diffuse-Type Gastric Adenocarcinoma and Metastasis
Authors: Park Jun Won , Jang Seok Hoon , Park Dong Min , Lim Na Jung , Deng Chuxia , Kim Dae Yong , Green Jeffrey E. , Kim Hark Kyun
Published: April 2023

PDF - 268K, Supplementary Materials and Methods and Supplementary Results. Table S1. Incidence of adenocarcinomas in each organ according to the genotype. Table S2. Gene sets most enriched in 1,096 genes upregulated in gastric adenocarcinomas at P < 0.001 Table S3. Clinicopathologic characteristics of young gastric cancer patients. Supplementary Figure Legends.
Figures S1 through S7 from Transposon Mutagenesis Screen Identifies Potential Lung Cancer Drivers and CUL3 as a Tumor Suppressor
Authors: Dorr Casey , Janik Callie , Weg Madison , Been Raha A. , Bader Justin , Kang Ryan , Ng Brandon , Foran Lindsey , Landman Sean R. , O'Sullivan M. Gerard , Steinbach Michael , Sarver Aaron L. , Silverstein Kevin A.T. , Largaespada David A. , Starr Timothy K.
Published: April 2023

Figures S1 through S7. Figure S1: Diagram of alleles. Figure S2: SB expression in lung Figure S3: Kaplan Meier Survival Curves Figure S4: Necropsy Images Figure S5: Thyroid AdCa and Mets. Figure S6: Transposon insertions in Cul3. Figure S7: CUL3 and PTEN Protein levels in knockdown and control A549 and H2030 cell lines.
Supplementary Figure 4 from Cooperativity of E-cadherin and Smad4 Loss to Promote Diffuse-Type Gastric Adenocarcinoma and Metastasis
Authors: Park Jun Won , Jang Seok Hoon , Park Dong Min , Lim Na Jung , Deng Chuxia , Kim Dae Yong , Green Jeffrey E. , Kim Hark Kyun
Published: April 2023

PDF - 172K, Histological findings of mammary adenocarcinoma.
Supplementary Figure 1 and Table 1 from Novel Bispecific Domain Antibody to LRP6 Inhibits Wnt and R-spondin Ligand-Induced Wnt Signaling and Tumor Growth
Authors: Jackson Heather , Granger David , Jones Gavin , Anderson Louisa , Friel Sarah , Rycroft Daniel , Fieles William , Tunstead James , Steward Michael , Wattam Trevor , Walker Adam , Griggs Jeremy , Al-Hajj Muhammad , Shelton Christopher
Published: April 2023

Supplementary Figure 1: Testing GSK3178022 binding to human LRP6, mouse LRP6 and human LRP5 in an ELISA format. Supplmentary Table 1: Mutation data in PDX models
Supplementary Figure 10 from Cooperativity of E-cadherin and Smad4 Loss to Promote Diffuse-Type Gastric Adenocarcinoma and Metastasis
Authors: Park Jun Won , Jang Seok Hoon , Park Dong Min , Lim Na Jung , Deng Chuxia , Kim Dae Yong , Green Jeffrey E. , Kim Hark Kyun
Published: April 2023

PDF - 83K, E-cahderin expression after knockdown of beta-catenin.
Supplementary Figure 1 from Cooperativity of E-cadherin and Smad4 Loss to Promote Diffuse-Type Gastric Adenocarcinoma and Metastasis
Authors: Park Jun Won , Jang Seok Hoon , Park Dong Min , Lim Na Jung , Deng Chuxia , Kim Dae Yong , Green Jeffrey E. , Kim Hark Kyun
Published: April 2023

PDF - 106K, Timing of necropsy.
Supplemental Figure 7 from EMT Transition Alters Interstitial Fluid Flow–Induced Signaling in ERBB2-Positive Breast Cancer Cells
Authors: Tchafa Alimatou M. , Ta Mi , Reginato Mauricio J. , Shieh Adrian C.
Published: April 2023

Supplemental Figure 7: TGF-β1 induces EMT in NeuN.
Supplemental Figure 2 from EMT Transition Alters Interstitial Fluid Flow–Induced Signaling in ERBB2-Positive Breast Cancer Cells
Authors: Tchafa Alimatou M. , Ta Mi , Reginato Mauricio J. , Shieh Adrian C.
Published: April 2023

Supplemental Figure 2: Levels of CXCR4 and CXCL12 in NeuT and NeuN.
Supplemental Figure 1 from EMT Transition Alters Interstitial Fluid Flow–Induced Signaling in ERBB2-Positive Breast Cancer Cells
Authors: Tchafa Alimatou M. , Ta Mi , Reginato Mauricio J. , Shieh Adrian C.
Published: April 2023

Supplemental Figure 1: Schematic of 3D invasion assay.
Supplementary Figures 1-8 from Combined Targeting of G9a and Checkpoint Kinase 1 Synergistically Inhibits Pancreatic Cancer Cell Growth by Replication Fork Collapse
Authors: Urrutia Guillermo , Salmonson Ann , Toro-Zapata Jorge , de Assuncao Thiago M. , Mathison Angela , Dusetti Nelson , Iovanna Juan , Urrutia Raul , Lomberk Gwen
Published: April 2023

Supplementary Figure 1. Prexasertib and BRD4770 synergistically inhibit cell growth in PDAC cell lines. Supplementary Figure 2. CHK1 and G9a inhibition has a synergistic effect on human primary PDAC cell lines. Supplementary Figure 3. Long-term effect of prexasertib and BRD4770 combination treatment demonstrates significant inhibition of cell survival in clonogenic assays. Supplementary Figure 4. Combined prexasertib and BRD4770 treatment is effective in vivo. Supplementary Figure 5. Combination treatment induces Caspase 3/7 activation and apoptotic cell death. Supplementary Figure 6. Combination treatment does not modify the level of dsDNA breaks in L3.6 cells. Supplementary Figure 7. Combined CHK1 and G9a inhibition induces phosphorylated RPA32 and H2A.X double-positive cells. Supplementary Figure 8. Synergistic effect is not observed with predicted non-synergistic concentrations of prexasertib and BRD4770.