bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of add-on Ayurveda treatment in the management of chickenpox
Authors: Ekka Ranjita , Dogra Ekta , Nair Parvathy G. , Dixit Amit K. , Choudhary Kuldeep , Das Debajyoti , Prasad Peyyala Vara Venkatesh
Published: September 2023

BACKGROUND:

Chickenpox is a contagious infection caused by the Varicella-zoster virus with the clinical manifestation of itchy rashes with fluid-filled blisters and fever. Although it is a self-limiting disease, to shorten the recovery period as well as to avoid complications, Ayurveda medicine could be effectively used in the management of chickenpox. In the present case study, the effects of Ayurveda add-on treatment are studied in treating chickenpox and in healing papules.

CLINICAL PRESENTATION AND DIAGNOSIS:

A 38-year-old woman presented to the Out-Patient Department (OPD) of Central Ayurveda Research Institute, Kolkata, with severe itchy and painful papules all over the body and malaise along with difficulty in swallowing because of pain in the throat since 15 days. On the basis of clinical presentation, it was diagnosed as a case of chickenpox.

INTERVENTION AND OUTCOME:

Before visiting the Ayurveda OPD, the patient took allopathic medicine (acyclovir 800 mg TID, paracetamol SOS, and calamine lotion local application) for 15 days, but the disease continued to progress and developed painful lesions with itching and other difficulties. The Ayurveda intervention started after 2 weeks of the onset of the disease. The patient was advised to take Tribhuvankirti Rasa (250 mg BD) before food for 7 days, Haridrakhanda (3 g BD) after food, Panchatiktaghrita (5 mL BD) after food, and Guduchyadi Taila for local application for 15 days.

RESULTS:

Papules of chickenpox were healed in 15 days of the treatment. After taking Ayurveda medicines, the patient got relief from severe itching and pain within 2 days and also completely recovered within 15 days.

CONCLUSION:

Results suggest that the Ayurveda interventions effectively reduced the signs and symptoms of chickenpox and hastened the healing process. It may be concluded that Ayurveda medicines either alone or as add-on give promising therapeutic results in the management of chickenpox.
Integration of Ayurveda and allopathic medicine: Opinion of experts who participated in the working group meetings for the preparation of the WHO benchmarks for the training and practice of Ayurveda
Authors: Berra Jorge Luis
Published: September 2023

The World Health Organization (WHO) has recognized the importance of integrating traditional systems of medicine, including Ayurveda, with conventional medicine, and has taken several initiatives to promote this integration. The Ministry of AYUSH, Government of India, agreed to host two WHO Working Group Meeting that took place at National Institute of Ayurveda (2018) and at Institute of Teaching and Research in Ayurveda (2019) for developing the WHO Benchmarks in Ayurveda with the participation of 27 experts from the six regions of World Health Organization. These WHO Benchmarks on Training and Practice of Ayurveda were published in March 2022. Excluding the author, 23 (89%) of the experts which participated in the said meetings answered a questionnaire about the integration of Ayurveda and allopathic medicine. A very significant majority of these experts (95%) considered that Ayurveda can make important contributions to conventional medicine and are in favor of the integration of Ayurveda and allopathic medicine. There is also a majority consensus that conventional physicians should have training in Ayurveda at both the undergraduate and graduate levels and that they should have training in Ayurvedic remedies. A large proportion of the experts consulted consider the prevailing view in the Ayurvedic government and official environment in India to be in favor of integration with allopathy, and a significant but somewhat smaller number appreciate this same trend in the Ayurvedic academic field of India. It is significant that almost two thirds believe that in the West, Ayurveda should be a specialty within conventional medicine.
Morbidity and treatment costs of cystic fibrosis in a middle-income country
Authors: Hng Shih Ying , Thinakaran Agnes Suganthi , Ooi Chiou Jia , Eg Kah Peng , Thong Meow Keong , Tae Sok Kun , Goh Saw Huan , Chew Kee Seang , Tan Lay Teng , Koh Mia Tuang , Chong Li Ai , Khalid Farah , Ng Ruey Teng , Nathan Anna Marie , de Bruyne Jessie Anne
Published: September 2023

Introduction:

Asian children with cystic fibrosis (CF) managed in Malaysia have significant morbidity with limited access to life-sustaining treatments. We determined the morbidity and treatment cost of CF in a resource-limited country.

Methods:

This cross-sectional study included all children diagnosed with CF in our centre. Data on clinical presentation, genetic mutation, serial spirometry results and complications were collected. Out-of-pocket (OOP) and healthcare costs over 1 year were retrieved for patients who were alive. Cohen’s d and odds ratio (OR) were used to determine the effect size.

Results:

Twenty-four patients were diagnosed with CF. Five patients died at a median (range) age of 18 (0.3–22) years. F508deletion (c. 1521_1523delCTT) was found in 20% of the alleles, while 89% of the variants were detected in nine patients. Body mass index (BMI) Z score was >−1.96 in 70.6% of patients. Two thirds (68%) were colonised with Pseudomonas aeruginosa, and this was associated with lower weight (P = 0.009) and BMI (P = 0.02) Z scores. Only 18% had FEV1 Z scores >−1.96. Early symptom onset (d = 0.74), delayed diagnosis (d = 2.07), a low FEF25–75 Z score (d = 0.82) and a high sweat conductance (d = 1.19) were associated with death. Inpatient cost was mainly from diagnostic tests, while medications contributed to half of the outpatient cost. Healthcare utilisation cost was catastrophic, amounting to 20% of the total income.

Conclusion:

Asian children with CF suffer significant complications such as low weight, low lung function and shortened lifespan. P. aeruginosa colonisation was frequent and associated with poor growth. Healthcare cost to parents was catastrophic.
Approach to headache disorders and the management of migraine: consensus guidelines from the Headache Society of Singapore, first edition (2023)
Authors: Zhao Yi Jing , Idu Jion Yasmin Bte , Ho King Hee , Wong Pei Shieen , Lo Yew Long , Chan Yee Cheun , Ang Lai Lai , Yeo Sow Nam , Soh Soon Beng , Wu Tuck Seng , Yuan Ong Jonathan Jia
Published: September 2023

Headache disorders, particularly migraine, are one of the most common and disabling neurological disorders. There is a need for high-quality, accessible care for patients with headache disorders across all levels of the healthcare system in Singapore. The role of the Headache Society of Singapore is to increase awareness and advance the understanding of these disorders and to advocate for the needs of affected patients. In this first edition of local consensus guidelines, we focus on treatment approaches for headaches and provide consensus recommendations for the management of migraine in adults. The recommendations in these guidelines can be used as a practical tool in routine clinical practice by primary care physicians, neurologists and other healthcare professionals who have a common interest in headache disorders.
Disease Prediction Using a Modified Multi-Layer Perceptron Algorithm in Diabetes
Authors: Dayal Karan , Shukla Manmohan , Mahapatra Satyasundara
Published: September 2023

This paper presents an adaptation of the Multi-Layer Perceptron (MLP) algorithm for use in predicting diabetes risk. The aim is to enhance the accuracy and generalizability of the model by incorporating preprocessing techniques, dimensionality reduction using Principal Component Analysis (PCA), and improvements in optimization and regularization. Several factors, including glucose level, pregnancy, blood pressure, and body mass index, are taken into account when analyzing the PIMA Indian Diabetes dataset. Modern optimization methods, dropout regularization, and an adaptive learning rate are incorporated into the modified MLP model to fine-tune the model's weights and boost its predictive abilities. The effectiveness of the modified MLP algorithm is evaluated by comparing its performance with baseline machine learning methods and the original MLP algorithm in terms of accuracy, sensitivity, and specificity. The results of this study can improve the quality of healthcare provided to people at risk for developing diabetes and thus contribute to the development of better prediction models for the disease.
Design of efficient Programming Language with Lexer using ’$’-prefixed identifier
Authors: Gupta Priya , Kumar L S Yaswanth , Santosh J V V M S D , Kumar D Yashwanth , Dinesh Chokkari , Venkata Chalapathi Mukkoti Maruthi
Published: September 2023

An identifier which starts with ‘$‘is known as ‘$‘-prefixed identifier and this type of identifiers are used in our research paper to improve the lexical analysis phase. This paper talks about a new programming language with ‘$‘-prefixed identifier that features a novel approach for optimizing the lexer for efficient lexical analysis which can be applied to any existing language. This approach is used to classify identifiers and keywords using ‘$‘-prefixed variables, which significantly reduces the time taken and number of iterations required during the tokenization process, leading to improved overall performance. This type of language structure allows for fast lookup and matching of tokens. We conducted a series of experiments to evaluate the performance of our lexer and compared it with a regular lexer. Our results show that our approach leads to significant improvements in time complexity and number of iterations for identifying whether the token is an identifier or a keyword, resulting in faster compilation times and improved overall performance. Our language has reduced the amount of time taken by 7-10% and 45-50% in terms of iterations. Our language and lexer represent a significant step forward in the design and implementation of high-performance programming languages by reducing the number of iterations and time taken to identify whether a token is a keyword or an identifier.
Thinking for Soul, Reforming to Empower, and Cooperating to Strengthen Foundation: Responding to Implementation of Educational Reform of Civics and Political Science with Fuzzy Theory Algorithm
Authors: Wang Caihua , Liang Weidong , Wu Shuxia
Published: September 2023

INTRODUCTION: Against the background of the new period of casting souls in Civics, empowering reforms, and strengthening foundations through cooperation, it is necessary to put the educational concepts and strategies of the Party and the government into practice in the process of deepening the educational reform of Civics and Politics courses. OBJECTIVES: This paper starts from the practical feasibility of the work and the conditions of the course design, with clear objectives, optimizing the teaching content, innovating and improving the teaching mode, and gradually forming effective strategies and methods of educational thought and policy. METHODS: This work examines and synthesizes the challenges and strategies of ideological and political education reform in the contemporary era, employing fuzzy theory and algorithmic approaches. RESULTS: It is concluded that the reform of the ideological and political curriculum is not only suitable for the development of students but also for the development of an era. Therefore, it is necessary to retain the content of all new textbooks, pay attention to the inclusion of ideological and political content in all textbooks, and ensure that there are scientifically sound and appropriate teaching materials for all teaching materials in order to contribute to the development of curriculum ideology and politics effectively. CONCLUSION: In the implementation process, it is necessary to improve the comprehensive quality of ideological and political course teaching, establish a sound ideological and political teaching system, and set up a comprehensive construction and educational collaboration mechanism. A multifactor ideological and political learning platform has been created to promote closer integration and interaction between theoretical learning and value orientation.
Cloud DDoS Attack Detection Model with Data Fusion & Machine Learning Classifiers
Authors: Pattnaik Lal Mohan , Swain Pratik Kumar , Satpathy Suneeta , Panda Aditya N.
Published: September 2023

In the current situation, digital technology is a necessary component of daily life for people. During the Covid-19 pandemic, every profit and non-profit making businesses organizations moved online, which caused an exponential rise in incursions and attacks on the digital platform. The Distributed Denial of Service (DDoS) attack, which may quickly paralyse Internet-based services and applications, is one of the deadly threats to emerge. The attackers regularly update their skill tactics, which allows them to get around the current detection and protection systems. The standard detection systems are ineffective for identifying novel DDoS attacks since the volume of data generated and stored has multiplied. So, the main goal of this work is to employ data fusion applications for secure cloud services and demonstrate the detection of DDoS attacks with the applications of machine learning classifiers that can further be helpful for cloud forensic investigation process. A variety of machine learning models, including decision trees, Navies Bayes, SVM, and KNN are used to detect and classify cloud DDoS attacks. The outcomes of the experiments demonstrated that decision tree is the most feasible and better performer method to classify cloud DDoS attacks.
Establishing molecular pathology curriculum for pathology trainees and continued medical education: a collaborative work from the Molecular Pathology Study Group of the Korean Society of Pathologists
Authors: Koh Jiwon , Park Ha Young , Bae Jeong Mo , Kang Jun , Cho Uiju , Lee Seung Eun , Kang Haeyoun , Hong Min Eui , Won Jae Kyung , Choi Youn-La , Kim Wan-Seop , Lee Ahwon ,   The Molecular Pathology Study Group of the Korean Society of Pathologists
Published: September 2023

Background: The importance of molecular pathology tests has increased during the last decade, and there is a great need for efficient training of molecular pathology for pathology trainees and as continued medical education.Methods: The Molecular Pathology Study Group of the Korean Society of Pathologists appointed a task force composed of experienced molecular pathologists to develop a refined educational curriculum of molecular pathology. A 3-day online educational session was held based on the newly established structure of learning objectives; the audience were asked to score their understanding of 22 selected learning objectives before and after the session to assess the effect of structured education.Results: The structured objectives and goals of molecular pathology was established and posted as a web-based interface which can serve as a knowledge bank of molecular pathology. A total of 201 pathologists participated in the educational session. For all 22 learning objectives, the scores of self-reported understanding increased after educational session by 9.9 points on average (range, 6.6 to 17.0). The most effectively improved items were objectives from next-generation sequencing (NGS) section: ‘NGS library preparation and quality control’ (score increased from 51.8 to 68.8), ‘NGS interpretation of variants and reference database’ (score increased from 54.1 to 68.0), and ‘whole genome, whole exome, and targeted gene sequencing’ (score increased from 58.2 to 71.2). Qualitative responses regarding the adequacy of refined educational curriculum were collected, where favorable comments dominated.Conclusions: Approach toward the education of molecular pathology was refined, which would greatly benefit the future trainees.
Regularity of the scattering matrix for nonlinear Helmholtz eigenfunctions
Authors: Gell-Redman Jesse , Hassell Andrew , Shapiro Jacob
Published: September 2023

We study the nonlinear Helmholtz equation

(\Delta - \lambda^2)u = \pm |u|^{p-1}u

on

\mathbb{R}^n

,

\lambda > 0

,

p \in \mathbb{N}

odd, and more generally

(\Delta_g + V - \lambda^2)u = N[u]

, where

\Delta_g

is the (positive) Laplace–Beltrami operator on an asymptotically Euclidean or conic manifold,

V

is a short range potential, and

N[u]

is a more general polynomial nonlinearity. Under the conditions

(p-1)(n-1)/2 > 2

and

k > (n-1)/2

, for every

f \in H^k(\mathbb{S}^{n-1}_\omega)

of sufficiently small norm, we show there is a nonlinear Helmholtz eigenfunction taking the form

u(r, \omega) = r^{-(n-1)/2} ( e^{-i\lambda r} f(\omega) + e^{+i\lambda r} b(\omega) + O(r^{-\epsilon}) ), \quad \text{as } r \to \infty,

for some

b \in H^k(\mathbb{S}_\omega^{n-1})

and

\epsilon > 0

. That is, the nonlinear scattering matrix

f \mapsto b

preserves Sobolev regularity, which is an improvement over the authors' previous work (2020) with Zhang, that proved a similar result with a loss of four derivatives.
Solving strongly convex-concave composite saddle-point problems with low dimension of one group of variable
Authors: Alkousa Mohammad Soud , Gasnikov Alexander Vladimirovich , Gladin Egor Leonidovich , Kuruzov Ilya Alekseevich , Pasechnyuk Dmitry Arkad'evich , Stonyakin Fedor Sergeevich
Published: September 2023

Algorithmic methods are developed that guarantee efficient complexity estimates for strongly convex-concave saddle-point problems in the case when one group of variables has a high dimension, while another has a rather low dimension (up to 100). These methods are based on reducing problems of this type to the minimization (maximization) problem for a convex (concave) functional with respect to one of the variables such that an approximate value of the gradient at an arbitrary point can be obtained with the required accuracy using an auxiliary optimization subproblem with respect to the other variable. It is proposed to use the ellipsoid method and Vaidya's method for low-dimensional problems and accelerated gradient methods with inexact information about the gradient or subgradient for high-dimensional problems. In the case when one group of variables, ranging over a hypercube, has a very low dimension (up to five), another proposed approach to strongly convex-concave saddle-point problems is rather efficient. This approach is based on a new version of a multidimensional analogue of Nesterov's method on a square (the multidimensional dichotomy method) with the possibility to use inexact values of the gradient of the objective functional.
Bibliography: 28 titles.
Preoperative prediction of microvascular invasion in hepatocellular carcinoma using ultrasound features including elasticity
Authors: Jiang Dong , Qian Yi , Tan Bi-Bo , Zhu Xia-Ling , Dong Hui , Qian Rong
Published: September 2023

Indocyanine green (ICG) is a water-soluble fluorescent dye that is minimally toxic and widely used in gastrointestinal surgery. ICG facilitates anatomical identification of structures (e.g., ureters), assessment of lymph nodes, biliary mapping, organ perfusion and anastomosis assessment, and aids in determining the adequacy of oncological margins. In addition, ICG can be conjugated to artificially created antibodies for tumour markers, such as carcinoembryonic antigen for colorectal, breast, lung, and gastric cancer, prostate-specific antigen for prostate cancer, and cancer antigen 125 for ovarian cancer. Although ICG has shown promising results, the optimization of patient factors, dye factors, equipment, and the method of assessing fluorescence intensity could further enhance its utility. This review summarizes the clinical application of ICG in gastrointestinal surgery and discusses the emergence of novel dyes such as ZW-800 and VM678 that have demonstrated appropriate pharmacokinetic properties and improved target-to-background ratios in animal studies. With the emergence of robotic technology and the increasing reporting of ICG utility, a comprehensive review of clinical application of ICG in gastrointestinal surgery is timely and this review serves that aim.
Voluntary sustainability standards
Authors: Marx Axel , Depoorter Charline
Published: September 2023

The Elgar Encyclopedia of Environmental Law is a landmark reference work, providing definitive and comprehensive coverage of this dynamic field. The Encyclopedia is organised into 12 volumes around top-level subjects – such as water, energy and climate change – that reflect some of the most pressing issues facing us today. Each volume probes the key elements of law, the essential concepts, and the latest research through concise, structured entries written by international experts. Each entry includes an extensive bibliography as a starting point for further reading. The mix of authoritative commentary and insightful discussion will make this an essential tool for research and teaching, as well as a valuable resource for professionals and policymakers.
The Idea of Technological Innovation
Authors: Godin Benoît
Published: September 2023

This timely book explores technological innovation as a concept, dissecting its emergence, development and use. Beno"t Godin offers an exciting new historiography of the subject, arguing that the study of innovation originates not from scholars but from practitioners of innovation.
NÂNG CAO TƯ DUY PHẢN BIỆN CHO SINH VIÊN THÔNG QUA GIẢNG DẠY MÔN TRIẾT HỌC MÁC - LÊNIN TẠI TRƯỜNG ĐẠI HỌC CÔNG NGHIỆP THÀNH PHỐ HỒ CHÍ MINH
Authors: NGUYỄN THỊ THÚY CƯỜNG
Published: September 2023

Bài viết làm rõ một số vấn đề lý luận về tư duy phản biện và một số vấn đề lý luận của triết học Mác - Lênin về khái niệm, vai trò của tư duy phản biện cũng như vai trò của triết học trong việc nâng cao năng lực tư duy phản biện cho sinh viên. Sự cần thiết nâng cao tư duy phản biện cho sinh viên thông qua giảng dạy môn triết học Mác - Lênin. Nghiên cứu thực trạng nâng cao tư duy phản biện cho sinh viên thông qua dạy học môn triết học Mác - Lênin tại Trường Đại học Công nghiệp Thành phố Hồ Chí Minh, chỉ ra những kết quả đạt được và một số hạn chế. Trên cơ sở đó, bài viết đưa ra một số định hướng nhằm phát triển tư duy phản biện cho sinh viên tại trường Đại học Công nghiệp Thành phố Hồ Chí Minh trong giai đoạn hiện nay.
IVF Stimulation - personalized, optimized, and simplified using an advanced decision-support tool: A randomized trial
Authors: Diwekar Urmila , Patel Nayana , Patel Niket , Bhandarka Harsha , Patel Molina , Ghoghari Paresh , Vyas Kairavi , Joag Sanjay
Published: September 2023

We assessed the effectiveness of a clinical decision support tool to reduce total cumulative follicle-stimulating hormone dosage used, to eliminate the need for ultrasound exams after day 5 of an individual superovulation cycle, and to improve the number of high-quality embryos obtained. The design we used was a Randomized Control Trial in a private fertility center. This study included 93 women aged 25–45 years undergoing IVF. 48 Test and 45 Control participants included normal and poor responders and patients with polycystic ovarian syndrome. A clinical decision support tool was used to forecast stimulatory hormone dosing for an individual cycle based on follicle size distribution on day 1 and day 5. Cumulative stimulatory hormone doses, oocytes retrieved, number of Mii oocytes, total embryos, high-quality embryos obtained during the cycle, and clinical pregnancy rates was the main outcome measures. Test participants required significantly lower cumulative FSH doses during superovulation cycles (average 1883 IU test, 2530 IU control, p <0.01), with significantly higher numbers of total embryos (average 5.4 test, 3.5 control, p<0.01), and high-quality embryos (average 3.1 test, 1.2 control, p<0.01). Test participants had higher Mii follicles, although the difference was not statistically significant. The clinical pregnancy rate reported was significantly higher for test participants than control participants (52% test, 26% control, p<0.05). The test group had more poor responders and PCOS patients than the control group. In conclusion, the clinical decision support tool eliminated the need for ultrasound exams after day 5, reduced the doses of stimulatory hormone required, yielded significantly higher numbers of high-quality embryos, and resulted in higher clinical pregnancy rates.
Age-related change in AMH in women seeking fertility – a hospital-based study across India
Authors: Murdia Kshitiz , Chandra Vipin , Bhoi Nihar R. , Murdia Nitiz , Aggarwal Ritesh , Shah Naval , Naik Nagadeepti , Nigam Shipra , Puhani Ritu , Suwalka Isha
Published: September 2023

Objective

The emergence of Anti-Mullerian Hormone (AMH) as a reliable biomarker for evaluating ovarian reserve in females indirectly predicting fertility potentials. Related studies contribute to the importance of AMH level tests for ovarian reserve, but limited studies are there to contribute to the geographical distribution of AMH levels in PAN India. This study assessed the age-related change in AMH in the Indian scenario.

Design and Setting

This is a retrospective hospital-based study.

Patient(s)

The study included 1,71,595 Indian infertile females visiting different clinics of Indira IVF Hospital Private Limited during the year August 2015 –August 2022 in the age group of 21-50 years.

Intervention(s)

NA

Result(s)

The average AMH included in the study was 2.66±1.89 ng/mL. The maximum number of females younger than 30 years had AMH levels of 3.86 ±3.12 ng/mL, and those in older age (31-50 years) group had AMH levels of 2.86 ± 2.7ng/mL. The analysis revealed that AMH levels were negatively correlated with age in all four zones (South, West, East, and North). The correlation coefficients ranged from -0.394 to -0.423, indicating a moderate negative relationship between age and AMH levels. The median AMH levels in the different zones ranged from 1.76 to 2.24 ng/dl. In contrast, the mean AMH levels varied between 2.54±2.75 and 3.03±2.94 ng/dl, indicating some variability in the distribution of AMH levels across the regions.

Conclusion(s)

The result shows a moderate correlation between females and AMH where r = -0.418 across India. The AMH value shows a sharp fall around 27 years of age.
Descriptive analysis of Rekovelle® “real-world” experience
Authors: Borges Edson , Braga Daniela , Guilherme Patricia , Iaconelli Assumpto , Setti Amanda
Published: September 2023

Objective(s)

To describe the data on “real-world” Rekovelle® administration concerning the response to controlled ovarian stimulation (COS) and clinical intracytoplasmic sperm injection (ICSI) outcomes.

Study design

This non-interventional study based on secondary use of data included 763 patients undergoing ICSI treatment in a private university-affiliated IVF center from January 2018 to December 2021. Patients undergoing COS with Follitropin delta were given 16mcg Rekovelle® daily (n = 362). Ovarian response to stimulation and laboratory and clinical outcomes of ICSI were described. Two cohorts of patients were added as references: the population included in the ESTHER-1 trial (extern), and a population undergoing COS with follitropin alpha (on-site).

Results

Patients in the Follitropin delta group showed acceptable outcomes in terms of number of follicles and oocytes, oocyte maturity rate, blastocyst development, and clinical outcomes, irrespective of subgroups of age and BMI. Embryos from women using follitropin delta showed morphokinetic development that seemed equivalent to those from implanted embryos previously reported, demonstrating high implantation potential. This was further corroborated by satisfactory cumulative implantation rates observed for this group of patients. The modified protocol seems to not interfere with oocyte and embryo competence since euploidy rates were also within the expected ranges. OHSS frequencies and rates also seemed acceptable.

Conclusions

Descriptive data showed that using a starting 16 ug follitropin delta dose for COS results in satisfactory retrieved oocytes and maturity rates across patients in different age ranges and BMI, leading to reasonable cumulative pregnancy rates without increasing OHSS.
Methods to improve frozen-thawed blastocyst transfer outcomes- the IVF laboratory perspective
Authors: Michailov Yulia , Friedler Shevach , Saar-Ryss Bozhena
Published: September 2023

During the last few years, the number of frozen-thawed embryo transfer cycles (FET) significantly increased due to the universal application of more efficient cryopreservation techniques in the IVF laboratory and the improved survival rates of blastocyst stage embryos and the wide implementation of “freeze all” IVF cycles to prevent OHSS, or for preimplantation genetic testing for aneuploidy (PGT-A). Blastocyst cryopreservation allows single embryo transfers to reduce the rate of multiple pregnancies and improve perinatal outcomes. There is no consensus regarding the optimal laboratory protocol for blastocyst cryopreservation, and research is ongoing for its amelioration. This review summarizes different laboratory methods that may improve frozen-thawed blastocyst embryo transfer outcomes, alone or in combination. Some of the techniques relate to embryo survival; some of them work on endometrial receptivity.
Bicornuate uterus with recurrent miscarriage treated with Sitagliptin and PRP: A Case Report of a Successful Pregnancy
Authors: Arjunan Agilan
Published: September 2023

Research has shown that recurrent miscarriage can be due to loss of endometrial mesenchymal stem-like progenitor cells (eMSC) and excessive decidual senescence. Sitagliptin has been shown to increase eMSC in the endometrial tissue and decrease decidual senescence.

Case

This is a case report for a 31-year-old woman with a bicornuate uterus who suffered recurrent miscarriages with IVF treatment. IVF treatment was done due to male factor infertility in a modified stimulation protocol using oral clomifene and human menopausal gonadotrophin. A total of 10 blastocysts were cryopreserved. The couple could not afford to do a PGT-A testing on the cryopreserved embryos. Initial three frozen embryo transfers were done in a natural cycle but resulted in biochemical pregnancies. Thyroid function test and Anti-phospholipid Syndrome tests were negative. Her Protein C level was slightly low at 63%. Hysteroscopy showed no abnormalities in both the uterine horns. A fourth embryo transfer was done in a medicated cycle which resulted in no pregnancy. She was started on oral Sitagliptin 100mg once daily for 3 months. Following this, a fifth embryo transfer was done in a natural cycle. Endometrial PRP infusion was done in this cycle. She successfully became pregnant and delivered a baby girl via LSCS in August 2023.

Conclusion

Sitagliptin can be a cost-effective adjunct treatment for patients with recurrent miscarriage. While the absence of PGT-A may raise questions regarding the underlying cause of her recurrent miscarriages, oral Sitagliptin can be an option in cases of financial constraint or limited resources.
A Case of Ductal Carcinoma In situ of Breast with Poland Syndrome
Authors: Wong TCM , Lim J , Lim TC
Published: September 2023

Introduction: A 51-year-old woman was diagnosed with a rare case of multi-focal ductal carcinoma in situ (DCIS) of the breast associated with Poland syndrome.

Clinical Picture: Physical examination showed mild hypoplasia of the left breast with microcalcifications on mammogram. Intraoperatively, there was complete absence of the pectoralis major, which precluded the insertion of a breast implant.

Treatment and Outcome: She underwent a skin-sparing mastectomy and autologous microsurgical free flap reconstruction with deep inferior epigastric perforator (DIEP) flap. Postoperative recovery was uneventful with no evidence of recurrence at 6 months.

Conclusion: This is the first reported case of DCIS of the breast with Poland syndrome. We performed a skin-sparing mastectomy with immediate DIEP flap reconstruction. Patient recovered well postoperatively with no evidence of recurrence at 6 months.
Self Esteem pada Remaja Korban Kekerasan dalam Pacaran di Kecamatan Krembung
Authors: Kurniawati Anjar Haziziah , Fahmawati Zaki Nur
Published: September 2023

This study aims to describe the self-esteem of adolescent victims of dating violence, as well as the factors that influence the victim's self-esteem. This study uses a qualitative approach to the type of phenomenological research. The subjects of this study were 3 (three) adolescent victims of dating violence, namely AD, DR, and PT. The data collection method in this study used semi-structured interviews. Testing the validity of the data was carried out using the time triangulation method, which is a way to check the credibility of the data through semi-structured interview techniques with several research informants carried out under different conditions or times. The data analysis technique used is data reduction, data display, and then the data is verified as a research result. The results showed that there were similarities in the self-esteem of the three research subjects in terms of self-significance and benevolence, apart from that there were differences in the details of the forms of other aspects such as individual strengths and abilities as well as the factors that influenced them.
BIOMASS PRODUCTION IN SPRING HABIT TRITICALE (X Triticosecale Wittmack) ELITE LINES
Authors: Rodríguez-Pérez Gilberto , Reynaga-Franco Felipe de Jesús , Cadena-Cadena Francisco , Cervantes-Ortiz Francisco , Gámez-Vázquez Alfredo Josué , Ávila-Perches Miguel Ángel , Mayek-Pérez Netzahualcóyotl , García-Ramírez Alejandro
Published: September 2023

In plant breeding, genotype behavior analysis under different development conditions and years of evaluation allows for the identification of desirable individuals. In this study, forage biomass production of 20 elite lines of spring habit triticale (X Triticosecale Wittmack) determined over a two-year evaluation period. The research was conducted in autumn-winter seasons of 2016-2017 and 2017-2018 in Celaya, Guanajuato, Mexico. It was carried out using a randomized complete block experimental design with three replications per year and combined analysis. The experimental unit included two furrows in an area of 8.0 m2. The variables measured were those related to green and dry forage yield, number of stems, number of leaves, and plant height in the milky-mass stage. Lines L-3, L-9, and L-4 showed higher averages of green and dry forage, more stems and leaves, increased plant height, and presented a late cycle; L-18, L-20, and L-19 yielded less, with a tendency to earlier and smaller plant size. The combined analysis revealed significant differences (p ≤ 0.05); the biplot showed that lines L-17, L-5, L-9, L-20, L-4, and L-19 had higher production in the first year of evaluation for green and dry forage, number of stems, as well as a higher number of leaves.
Phenotypic stability of forty advanced lines of rice at Babahoyo, Ecuador
Authors: Maldonado Cristina , Reyes Walter , Duicela Luis , Cobos Fernando
Published: September 2023

The crosses between Oryza sativa L. and O. rufipogon Griff., create a high genetic diversity to develop rice varieties with high yield and phenotypic stability. In the present investigation, forty advanced lines of rice were evaluated in subsidiaries F5 (dry season) and F6 (rainy season), together with three commercial controls in the town of Babahoyo, Ecuador. A Randomized Complete Block Design (DBCA) was applied with three repetitions, recording morphoagronomic and productive characters. Statistical analyzes were applied and phenotypic stability was determined using the Eberhart and Russell, AMMI, Lin and Binns, PROMVAR models. The average morphoagronomic results were: days to flowering (72), vegetative cycle (98 days), plant height (111 cm), panicle sterility (6 %); the productive variables the results were: tillers per plant (32), panicles per plant (31), panicle length (27 cm), grains per panicle (168) and yield (8,100 kg.ha-1). The stable lines identified by the models: Eberhart and Russell were 1, 2, 10, 11, 13, 18, 25, 26, 30 and 37; AMMI identified lines 8 and 22; Lin and Binns to lines 2, 12, 18, 27, 37 and 40; and PROMOTE lines 2, 10, 13, 18, 25, 30, 38, 40 and 43; concluding that seven lines (2, 10, 13, 18, 25, 30 and 40) coincided with the applied models except AMMI. The average yield of the lines mentioned in the two seasons was 7,797 kg.ha-1, higher than the average of the commercial controls that obtained 6,809 kg.ha-1.
Impact of Residents’ Trust on Behavioral Intention to Use Social Media for E-Administration Services
Authors: Hossain Mohammad Mainul , Mohd Adnan Hamedi , Rahman Muhammad Khalilur , Muhammad Mohd Zulkifli
Published: September 2023

Trust is the fundamental matter that improves residents’ willingness to utilize social media as a technology tool for e-administration facilities. Despite its significance in the e-administrative sector, there is a lack of empirical investigation on residents’ trust in behavioral intention to use social media for e-administrative services. This study investigates the antecedents of residents’ trust and its impact on their behavioral intention to use social media for e-administration services. An online survey platform was used to collect the data from Malaysian residents in Kuala Lumpur and Petaling Jaya area. Data were analyzed using the partial least square technique. The findings revealed that reliable information has a positive and highly significant influence on residents’ trust, whereas attitude, subjective norms, and perceived privacy did not significantly affect residents’ trust. The findings also indicated that residents’ trust significantly impacts behavioral intention to use social media for e-administrative services. The findings have significant insight into the residents’ trust and behavioral intention to use social media for e-administration facilities. The results of this research can help government associations and policymakers in the nation to adequately establish their systems in raising residents’ trust, driving towards their engagement through information technology, particularly social media technology for e-administration services.
Effects of Social Networking Sites Usage on Chinese Students’ Life Satisfaction in Malaysia: Cultural Identity as a Mediator
Authors: Zhao Wenwen , Osman Mohd Nizam , Omar Siti Zobidah , Yaakup Hani Salwah
Published: September 2023

Social networking sites (SNSs) serve as a powerful tool for international students to adapt to the host country and improve life satisfaction. However, the use of SNSs also brings negative influences on their life satisfaction. Additionally, the mechanisms by which this occurs are still unclear. This study employed an online cross-sectional survey of 267 Chinese students in Malaysia to explore the relationship between SNSs usage (usage engagement and acculturation usage) and life satisfaction by considering the mediating effect of host cultural identity and ethnic cultural identity. Data analysis relied on Statistical Package for the Social Sciences and AMOS software. The findings showed that SNSs usage engagement and two cultural identities helped to improve life satisfaction. Moreover, two cultural identities can explain how SNSs usage engagement influences life satisfaction. Contrary to expectations, acculturation usage had a non-significant influence on life satisfaction. However, under the mediating effect of host cultural identity, acculturation usage positively predicted life satisfaction. The research can provide references for the Malaysian government and educational institutions when introducing relevant policies to promote the life satisfaction of international students. The shortcomings and possibilities for future research are also discussed.
COVID-19 associated mucormycosis: A bibliometric analysis of Indian research based on Scopus
Authors: Dayal Devi , Gupta Brij Mohan , Bansal Jivesh , Singh Yogendra
Published: September 2023

Objective. Invasive fungal infections, specifically mucormycosis, showed a massive surge during the COVID-19 pandemic, forcing the global medical fraternity to research this highly fatal co-infection. India has contributed significantly to COVID-19-associated mucormycosis (CAM) research, but a bibliometric analysis of this research topic is scarce. Using established bibliometric methods, we aimed to provide the yield and impact of CAM research in India.
Design/Methodology/Approach. The publication data on CAM was extracted from Scopus. Data was analyzed using quality indices such as citations per paper (CPP), relative citation index (RCI), and total linkage strength (TLS).
Results/Discussion. India contributed 640 (61.2%) to 1045 global publications on CAM research involving 548 authors from 247 organizations. Only 62 (9.8%) and 96 (15.0%) publications were funded and collaborative. The CAM research was focused on clinical features (36.5%), complications (21.7%), risk factors (19.2%), epidemiology (12.3%), diagnostics & imaging (6.8%), treatment outcomes (4.5%), prognosis (3.4%) and pathophysiology (3.1%). The average CPP of Indian publications was 7.8 compared to 28.2 CPP in France, 17.8 CPP in the USA, 8.7 CPP in Saudi Arabia, 8.3 CPP in Bangladesh, and 8.1 CPP in Iran. The major collaborations were with the USA, Bangladesh, Saudi Arabia, the UK, Pakistan, Malaysia, and UAE. The most productive organizations were PGIMER-Chandigarh (n=47), AIIMS-New Delhi (n=44), and AIIIMS-Jodhpur (n=17), whereas the most impactful organizations were SMS Medical College, Jaipur, SGPGIMS, Lucknow and BJ Medical College, Ahmedabad. The most productive authors were A. Chakrabarti, V. Muthu, and R. Agarwal, and the most impactful were I.S. Sehgal, R. Agarwal, and V. Muthu. The most preferred journals were the Indian Journal of Ophthalmology, the Indian Journal of Otolaryngology and Head & Neck Surgery, and BMJ Case Reports.
Conclusions. Even though India is the topmost contributor to global CAM research, the quality of its publications is lower than those from France and the USA. The CAM research is largely non-funded. There is a need to improve international collaboration and increase focus on pathophysiology, epidemiology, and pediatric aspects. This may lead to an improved understanding of CAM and increase survival in affected patients.
ŞİDDET MAĞDURU KADINLARIN BOŞANMA SONRASI SÜREÇTE UYGULADIĞI EKONOMİK STRATEJİLER
Authors: Göker Mihriban , Selçuk Hava
Published: September 2023

Günümüzde kadına şiddet; televizyonda, gazetede, sanal ortamda veya günlük yaşamda sıklıkla karşılaşılan bir konu haline gelmiştir. Kadın, kadına şiddet, toplumda şiddet mağduru kadın ve şiddet nedeniyle boşanan kadınlar konusunda literatürde pek çok çalışma yapılmıştır. Hatta bu konuda şiddeti önlemek adına araştırmalar, stratejiler ve yaratıcı uygulamaları destekleyen ülkeler ve politikalar olmuştur. Bu tarz araştırmalar ve uygulamaların şiddetin önlenmesi anlamında önemi oldukça büyüktür. Ancak şiddet mağduru olup boşanan kadınların boşanma sonrası sürece nasıl adapte oldukları, hangi stratejileri kullandıkları, özellikle ekonomik anlamda neleri yaptıkları ve bu kadınların şiddet mağduru olan diğer kadınlara tavsiyeleri konusunda herhangi bir çalışmaya rastlanılmamıştır. İşte bu nedenle bu çalışma; şiddet mağduru kadınların boşanma sonrasında uyguladığı stratejilerden ekonomik stratejileri araştırarak literatüre katkı sunmayı ve şiddet mağduru olan boşanmış ya da boşanacak kadınlara yol gösterici olmayı hedeflemiştir. Boşanma sonrası şiddet mağduru kadınların uyguladığı ekonomik stratejileri keşfetmek adına literatürdeki verilerin taraması yapılmıştır. Ayrıca derinlemesine mülakat tekniği kullanılarak; Mersin ve Kayseri illerinde ikamet eden şiddet mağduru boşanmış 50 kadın katılımcıyla görüşülmüştür. Elde edilen veriler değerlendirilerek özetlenmiştir.
A Fault Detection and Protection Scheme for a 200 MVA Transformer using Fuzzy Logic
Authors: Rohit Khandu Jarande  , Rajat Rajesh Singh  , Anushka Dinesh Kadam  , Shreya Vinesh Tayade  , Dipti Krushnarao Sune  , Yashaswi Gajanan Rohane
Published: September 2023

The paper elucidates a fault detection and protection scheme for a 200MVA transformer using Fuzzy logic. Fuzzy logic (FL) tool box in MATLAB/ SIMULINK software was utilized in the simulation system that diagnosed transformer faults and also monitors its operating conditions. Current and rate of change of current with time have been identified as the input variables, duly represented in the programme as “Error” and “Error-Dot”. These variables have their universe of discourse from -1.5 to 1.5 and from -10 to 10 respectively. Fuzzy logic sensor is designed to monitor the current (i) conditions of the transformer at both ambient and full load. The results from the research show that whenever the output response is zero the current in transformer is normal. This is obtained when input values of [0] and [0] are injected into the system to produce a response of “6e-017” which is approximately zero. Whereas if the output response is greater than zero it implies that the transformer current is rising beyond normal and protection scheme should be alerted. This condition is achieved when input values of [-1.5] and [5] are used on the system to give a response of “+5”. However, if the response is less than zero then the transformer current is below normal, hence the protection scheme should be alerted. To investigate this, input values of [1.5] and [-5] gives a response of “-5”.
Synergistic Effect of Aluminum Lactate and Sodium Molybdate on Freshwater Corrosion of Carbon Steel Under Irradiation
Authors: Otani Kyohei , Kato Chiaki , Igarashi Takahiro
Published: September 2023

In this study, a corrosion inhibitor suitable for the corrosion inhibition of primary containment vessels at the Fukushima Daiichi Nuclear Power Station is investigated. Considering the internal environment of the primary containment vessels, the corrosion inhibitor should inhibit the freshwater corrosion of carbon steel under irradiation and should not come under effluent standards in Japan. Herein, a corrosion inhibitor was devised by combining Al lactate and Na molybdate that met the above conditions, and its corrosion mechanism was investigated. It was found that 0.75 mM Al lactate and 0.25 mM Na molybdate were the most inhibitive to the corrosion of carbon steel. As Al lactate has never been reported as a corrosion inhibitor for metallic materials, it could be developed as a novel corrosion inhibitor in this study. The corrosion inhibitor inhibited the freshwater corrosion of carbon steel even under gamma irradiation of 200 Gy/h. Al and molybdate ions in the solution formed a metal cation layer on carbon steel with few defects and without iron. This metal cation layer inhibited both the cathodic oxygen reduction reaction and the anodic iron dissolving reaction, thereby enhancing the corrosion protection of carbon steel in freshwater.