bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison of the effectiveness of giving warm compresses and cold compresses in handling dysmenorrhea: Systematic review
Authors: Melania Safitri  , Ratna Dwi Jayanti  , Endyka Erye Frety
Published: June 2023

Dysmenorrhea is the onset of pain during menstruation. More than 50% of women of reproductive age in the world experiencing dysmenorrhea. In Indonesia, 54.89% experienced primary dysmenorrhea, 9.36% experienced secondary dysmenorrhea with more than half (64.8%) feeling disturbed and experiencing decreased activity. The method of warm comrpresses and cold compresses are a form of non-pharmacological treatment that aims to reduce the degree of dysmenorrhea. The purpose of this study is to compare the effectiveness of giving warm compresses and cold compresses to the treatment of dysmenorrhea, so a deeper abalysis is neede regarding this matter. This study used a systematic review method on articles obtained from databases that is ScienceDirect, Pubmed, Scopus and Google Scholar. The results of literature selection based on MMAT and inclusion-exclusion characters obtained 5 literatures that matched the topic. 3 of the 5 selected literatures states that giving cold compresses is more effective in reducing the degree of dysmenorrhea pain compared to giving warm compresses. Giving cold compresses is stated to be more effective than giving warm compresses in reducing the degree of dysmenorrhea.
HUBUNGAN KEPATUHAN PEMAKAIAN APD SAAT PERTOLONGAN PERSALINAN TERHADAP RESIKO TERTULAR VIRUS COVID-19 DI UOBF PUSKESMAS DI KABUPATEN TUBAN
Authors: Margu Andriyati , Syarifah Has, S.KM., M.Epid Dwi Faqihatus
Published: June 2023

Penggunaan APD sudah disesuaikan dengan tingkat levelnya, namun tenaga kesehatan terkadang kurang patuh dan memperhatikan keselamatannya sehingga menggunakan serta melepas APD secara tidak tepat dan lengkap. Tujuan penelitian ini untuk menganalisis hubungan kepatuhan pemakaian APD level 3 saat pertolongan persalinan terhadap resiko tertular virus Covid-19 di UOBF Puskesmas di Kabupaten Tuban.

Desain penelitian adalah analitic observasional dengan pendekatan cross sectional. Populasi adalah tenaga kesehatan dalam pemakaian APD level 3 saat menolong persalinan dengan Covid-19 di UOBF Puskesmas Kabupaten Tuban Tahun 2022 berdasarkan data dari PC IBI Pemerintah Kabupaten Tuban-Jawa Timur tertanggal 03 Desember 2023 sejumlah 133 orang. Jumlah sampel sebanyak 100 orang diambil dengan teknik random sampling. Variabel bebas penelitian ini adalah kepatuhan pemakaian APD level 3, sedangkan variabel terikat yaitu Resiko tertular virus Covid-19. Instrumen yang digunakan penelitian ini adalah berupa data sekunder dari data rekap kuesioner APD level 3 dan skrining data pelayanan tenaga kesehatan dalam pemakaian APD level 3 saat menolong persalinan. Analisis menggunakan uji Somer pada tingkat kepercayaan 95% (p<0,05).

Hasil menunjukkan bahwa kepatuhan pemakaian APD level 3 saat pertolongan persalinan dengan pasien Covid-19 sebagian besar patuh, yaitu 70,0%, dan memiliki resiko tertular sebagian besar tinggi, yaitu 69,0%. Ada hubungan antara kepatuhan pemakaian APD level 3 saat pertolongan persalinan terhadap resiko tertular virus Covid-19 di UOBF Puskesmas Kabupaten Tuban dengan nilai p = 0,000 < 0,05.

Penguatan sikap tenaga kesehatan dalam kepatuhan penggunaan APD serta pengkajian ketersediaan APD yang dibutuhkan sesuai standar berpeluang menekan terjadinya resiko masalah kesehatan dan keselamatan kerja. Apabila pemakaian APD tidak lengkap maka akan beresiko besar resiko tertular virus Covid-19.
AN INCLUSIVE LOCAL IRREGULARITY VERTEX COLORING OF BOOK GRAPH FAMILY
Authors: Adawiyah Robiatul , Aima Muslihatul , Kristiana Arika Indah
Published: June 2023

Let  is a simple and connected graph with    as vertex set and  as edge set. Vertex labeling on inclusive local irregularity vertex coloring is defined by mapping and the function of the inclusive local irregularity vertex coloring is with . In other words, an inclusive local irregularity vertex coloring is defined by coloring the graph so that its weight value is obtained by adding up the labels of the neighboring vertex and its label. The inclusive local irregularity chromatic number is defined as the minimum number of colors obtained from coloring the vertex of the inclusive local irregularity in graph G, denoted by . In this paper, we learn about the inclusive local irregularity vertex coloring and determine the chromatic number on the book graphs.
ON THE THIRD ORDER SOLUTION OF KdV EQUATION BY USING HOMOTOPY PERTURBATION METHOD
Authors: Mashuri Mashuri , Zakiyah Yayah , Reorita Rina
Published: June 2023

In this research we discussed about the solution of the KdV equation using Homotopy Perturbation method. The KdV equation that describing water wave equation solved  by using the mixing method between Homotopy and Perturbation method. Homotopy was built with embedding parameter p∈[0,1] which undergoes a deformation process  from linear problems to nonlinear problems and the assumed solution of the KdV equation is expressed in the form of a power series p up to the third order. The result show that in each order solution  we obtained resonance term. for handling the condition, we used Lindsteadt-Poincare method.the wave number k2 and dispersion relation  can be obtained in the second order solution as the effect of using Lindsteadt-Poincare method.
COMPARISON OF K-MEANS AND GAUSSIAN MIXTURE MODEL IN PROFILING AREAS BY POVERTY INDICATORS
Authors: Wahidah Zumrotul , Utari Dina Tri
Published: June 2023

The Covid-19 pandemic has led to income degradation of the Indonesia population which potentially triggers poverty. According to the Indonesian Central Statistics Agency, the Province of Central Java is one of the areas that is most affected by Covid-19 especially on the economic aspect. In 2020, the percentage of poor people has increased by 0.6% from 2019. If this condition is ignored for the long term, it will have a negative impact on hampering national development. As a first step in designing a strategy for mitigating the impact of poverty, it is necessary to carry out an appropriate profiling of the areas affected on the economic aspect based on poverty indicators. This study compares the K-Means Clustering and Gaussian Mixture Model (GMM) in providing the best data grouping based on clustering indexes, including: connectivity, Dunn, and silhouette. GMM is a generalization of K-Means clustering to include information about the covariance structure of the data as well as latent Gaussian centers. We used poverty indicators data from Central Statistics Agency of Central Java, such as poverty line, percentage of poor population, poverty depth index, and poverty severity index.  The results obtained from this study indicate that the GMM gives the best results with the 3 clusters, with the number of members for the first, second, third is 10, 19, and 6 respectively.
MODELLING OF POVERTY PERCENTAGE IN EAST JAVA PROVINCE WITH SEMIPARAMETRIC REGRESSION APPROACH
Authors: Syahzaqi Idrus , A. Salman Alfarizi P. , Fithriasari Kartika
Published: June 2023

Poverty is an economic problem faced by all countries in the world, including Indonesia. Poverty is seen as the inability of a person from an economic standpoint to meet basic food and non-food needs as measured from the expenditure side. East Java Province is used as the object of research because this province has the highest economic growth in Java Island after DKI Jakarta province in the last 5 years. However, East Java is also included in the province with the highest number of poor people on the island of Java. Several independent variables that are thought to influence the percentage of poverty in East Java are the Open Unemployment Rate (TPT), Life Expectancy Rate (AHH), Average Years of Schooling (RLS), Population Density, and GRDP Rate. Sources of research data come from the East Java BPS website and East Java Open Data. Data analysis was performed using a semiparametric regression approach. The results of the analysis obtained good performance values, namely the MSE value of 12,2156 and the R2 value of 98,71%.
ANALYZING EARTHQUAKE ACTIVITY LEVELS IN NORTH SULAWESI USING MAXIMUM LIKELIHOOD METHOD AND GUTENBERG – RICHTER LAW
Authors: Wattimanela Henry Junus
Published: June 2023

Tectonic earthquakes are disasters that often cause damage to buildings and loss of life. The Province of North Sulawesi and its surroundings are earthquake-prone areas because they are located at the confluence of the major plates. This study aims to analyze the level of earthquake activity in the Province of North Sulawesi and its surroundings using the maximum likelihood method and the Guttenberg-Richter law. The distribution of the earthquake studied for the period 1941-2021 in the Province of North Sulawesi and its surroundings with a Mag ≥3.0 Mw and a depth ≤60 km. The data used comes from the Meteorological, Climatological, and Geophysical Agency Indonesia and ISC (International Seismological Center). The level of earthquake activity was reviewed based on nine groups of year intervals, three groups of depth levels, and the overall research area. The results show that the level of earthquake activity, rock fragility, and local stress at certain year intervals is sometimes high or low for the 1941-2021 earthquake period in North Sulawesi and its surroundings. The same condition for certain earthquake depths. On the other hand, the level of earthquake activity is quite high and the level of rock fragility is moderate in the research area as a whole.
DESIGN OF STUDENT SUCCESS PREDICTION APPLICATION IN ONLINE LEARNING USING FUZZY-KNN
Authors: Kharis Selly Anastassia Amellia , Hertono Gatot Fatwanto , Wahyuningrum Endang , Yumiati Yumiati , Irawan Sam Rizky , Danial T Ahmad , Saputra Dimas Septian
Published: June 2023

Effective evaluation of student performance is crucial. Hence, many kinds of techniques are used such as statistics, physical examination and currently data mining techniques to evaluate student performance. Data mining techniques as known as Educational Data Mining (EDM) collect, process, report and used to find the unseen patterns in the student dataset. EDM uses machine learning techniques to dig out useful data from multiple levels of meaningful hierarchy. Various data from intelligent computer tutors, classic computer based educational systems, online classes, academic data in educational institution, and standar assesment can be process for EDM. This led universities include open and distance learning (ODL) to collect large volume of student and learning data in their learning management systems (LMS). Students in ODL are relatively familiar with LMS and many learning activities such as number of accessing materials, student participation in discussion forum recorded in LMS. The processes of using EDM to improve the quality of educational policy maker with data-based models have become a challange that institutions of higher education face today. Therefore, this study aims to design applications that predict student performance in online learning using machine learning techniques based on EDM. The machine learning technique used in this research is Fuzzy-KNN. Testing using Fuzzy-KNN produces an accuracy of 92.5%.
COMPARISON OF ROBUST ESTIMATION ON MULTIPLE REGRESSION MODEL
Authors: Jana Padrul , Rosadi Dedi , Supandi Epha Diana
Published: June 2023

This study aimed to compare the robustness of the OLS method with a robust regression model on data that had outliers. The methods used on the robust regression model were M-estimation, MM-estimation, and S-estimation. The step taken was to check the characteristics of the data against outliers. Furthermore, the data were modeled with and without outliers using the OLS method and the M-, MM-, and S-estimations. The results were very different between the data with and without the outlier models in the OLS method. It was reflected in the intercept and standard error variables generated from the models. Meanwhile, the regression model with the M-, MM-, and S-estimations was quite stable and able to withstand the presence of outliers. Based on the three estimations that were robust against the outliers, the MM-estimation was the best candidate because, in addition to having a stable intercept parameter estimation, it also had the smallest standard error, which was 61.9 in the resulting model.
FORECASTING THE NUMBER OF FOREIGN TOURISM IN BALI USING THE HYBRID HOLT-WINTERS-ARTIFICIAL NEURAL NETWORK METHOD
Authors: Haris M. Al , Himmaturrohmah Laily , Nur Indah Manfaati , Ayomi Nun Maulida Suci
Published: June 2023

Bali was one of the destinations frequently visited by tourists because it had natural beauty, especially in the tourism sector. The number of foreign tourists coming to Bali until 2019 had increased, but there had been a very significant decrease in 2020. Forecasting the number of tourists coming to Bali in the future was needed to provide input or recommendations to the government and business people in anticipating decisions taken in the process of developing the tourism sector in Bali. One of the forecasting methods that can be used was the Holt-Winters method. The Holt-Winters method was part of Exponential Smoothing which is based on smoothing stationary, trend and seasonal elements. However, the Holt-Winters method can only capture linear patterns, so a method was needed that can capture non-linear patterns. The Artificial Neural Network method was proposed to overcome the shortcomings of the Holt-Winters Method. This research was focused on the number of foreign tourists visiting Bali using the Hybrid Holt Winters-Artificial Neural Network method. The results showed that the data on the number of foreign tourists fluctuated every month. The best method for predicting the number of foreign tourists was the Hybrid Holt-Winters (α = 0.987, β = 0.000001, and γ = 1)-Artificial Neural Network (12-15-1) because it has the best accuracy as indicated by the MAD value of 0.036684, MSE 0.01098698 and MAPE 6.30417%.
TEXT CLASSIFICATION OF TWITTER OPINION RELATED TO PERMENDIKBUD 30/2021 USING BIDIRECTIONAL LSTM
Authors: Fitriyah Zakiyatul , Kartikasari Mujiati Dwi
Published: June 2023

During the COVID-19 outbreak, sexual violence in Indonesia has risen. Sexual abuse is prevalent even within the realm of education. Many incidents of sexual assault are reported within the higher education sector. The Ministry of Education, Culture, Research, and Technology published Decree of the Minister of Education and Culture Number 30/2021 (Permendikbud 30/2021) on the Prevention and Handling of Sexual Violence in Higher Education in an effort to prevent sexual violence on campus. This regulation's issuance has become a popular topic of discussion on social media. Twitter is one of the social media platforms where opinions are expressed. The publication of Permendikbud 30/2021 elicited a variety of views, from those who supported the rule to those who did not. This study's objective is to categorize tweets about Permendikbud 30/2021. Bidirectional LSTM (BiLSTM) was utilized to classify data in this study. The accuracy values are 87%, the precision values are 82%, and the recall values are 96% based on the findings of the analysis comparing training data of 80% to testing data of 20%.
Viljan att bli ett med hästen
Authors: Nygren Anna
Published: June 2023

En litterär genre där djuren spelar en huvudroll är hästboken. Den här artikeln undersöker hur Inger Frimanssons hästboksserie KoNa-klubben (2011-2015) gestaltar relationer mellan människor och hästar, och hur dessa relationer mellan arter kan förstås ur ett posthumanistiskt perspektiv. Artikeln argumenterar för att den stallmiljö som Frimansson beskriver präglas av kunskapstraditioner och ekonomiska intressen, men att det samtidigt, inom ramen för detta, finns möjligheter för kärlek mellan arter att existera. Det är en på samma gång kroppslig och utomkroppslig kärlek. Artikeln undersöker hästbokens potential att vara ett populärkulturellt och flickfokuserat utrymme för en posthumanistisk förståelse av världen och människans relation till icke-mänskliga agenter.
"Kuitenkin siellä synkässä maailmassa näkyy myös toivoa"
Authors: Helle Anna
Published: June 2023

Artikkeli käsittelee tapaustutkimusta, jossa pieni joukko kirjallisuuden yliopisto-opiskelijoita luki Emmi Itärannan Teemestarin kirjan (2013) ilmastonmuutoksen näkökulmasta ja kirjoitti ja keskusteli lukemastaan. Tutkimus kuuluu empiirisen ekokritiikin alaan ja sen menetelmänä on teorialähtöinen temaattinen analyysi. Artikkelissa käsitellyt viisi teemaa ovat teoksen lukijoiden erilaiset lukukokemukset, teoksen dystooppinen maailma, fiktiivisen maailman suhde nykytodellisuuteen, kerronnan ja tyylin vaikutus sekä Teemestarin kirjan kannustavuus ja lannistavuus. Aineiston lukijat ovat todennäköisesti keskivertoa taitavampia lukijoita, joille myös ilmastonmuutos on etukäteen tuttu aihepiiri, joten heidän ei voi katsoa edustavan ketä tahansa lukijoita. Tämän tapaustutkimuksen perusteella näyttää kuitenkin siltä, että Teemestarin kirjan lukeminen auttaa kuvittelemaan, millaisia seurauksia ilmastonmuutoksella on paitsi ympäristölle myös ihmisille ja yhteiskunnille. Yksi keskeinen havainto on se, että henkilöhahmot jäävät lukijoille etäisiksi, kun taas teoksen fiktiivinen maailma koetaan vaikuttavaksi.
The project of Joseph Beuys "7000 oaks" as a way of healing from the injuries of historical memory
Authors: Larisa Victorovna Papina
Published: June 2023

The article is devoted to the project of Joseph Beuys “7000 oaks”. This project was created for the Documenta 7 in Kassel. It is the most ambitious project of the artist. In it, he proposed planting oaks on the way from Kassel to Russia. This project combines environmental, social and historical values. It seems relevant that the project also has a pacifist focus. The article also analyzes the installation “The End of the 20th Century”, which uses basalt slabs that were used in the “7000 Oaks”. Usually the “7000 Oaks” was considered from the environmental or social point of view. The article focuses on its historical context, since the circumstances of its creation between Germany and Russia, the post-war period and the taboo on the tragedy of the war make it possible to say that this was also relevant for that time. The scientific novelty of this study is an aspect of historical memory associated with the trauma of war.
Pengembangan Media Komik Digital Nussa Rara untuk Meningkatkan Minat Baca Peserta Didik Kelas III Madrasah Ibtidaiyah
Authors: Nisa' Rofiatun
Published: June 2023

Abstrak: Indonesia merupakan negara yang termasuk rendah minat untuk membaca. Sehingga perlu adanya media pembelajaran yang dapat membantu meningkatkan minat baca salah satunya dengan mengembangkan media komik digital yang masih jarang diterapkan oleh guru. Tujuan penelitian ini untuk mengetahui pengembangan media komik digital untuk meningkatkan minat baca peserta didik. Metode penelitian ini menggunakan Research and Development dengan mengacu pada model ADDIE. Subyek uji coba dalam penelitian ini adalah sepuluh sekolah di Kabupaten Lamongan yang berjumlah 352 Peserta didik. Instrumen pengumpulan data dalam penelitian ini menggunakan angket. Data angket dianalisis menggunakan kuantitatif deskriptif persentase dengan kualifikasi skala empat dalam pemberian makna, sedangkan efektivitas media dianalisis menggunakan uji t. Hasil pengembangan media komik digital nussa rara untuk meningkatkan minat baca peserta didik diperoleh: uji kelayakan oleh ketiga ahli dengan ketiganya berada pada kategori sangat baik. Media komik digital nussa rara efektif diterapkan kepada peserta didik dengan thitung > ttabel (2.806>1.960). Hasil uji kemenarikan media komik digital nussa rara didapatkan sebesar 94,86% dengan kategori sangat menarik.Abstract: Indonesia is a country that has a low interest in reading. Hence, it is necessary to have learning media that can help increase reading interest; one of which is by developing digital comic media for the teachers. The purpose of this study is to develop digital comics media to enhance students' reading interests. This research employed Research and Development design using the ADDIE model. The research subjects were from ten schools in Lamongan Regency, totaling 352 students. The data were collected using a questionnaire. The questionnaire results were analyzed and presented in percentages. Meanwhile, the effectiveness of the media was analyzed using the t test. The results showed that the Nussa Rara digital comics media could enhance students' reading interests. The feasibility test by the three experts exhibited the very good category. The Nussa Rara digital comics media can be effectively applied to students with tcount > ttable (2.806>1.960). Last but not least, the attractiveness test results of the Nussa Rara digital comics media showed 94.86% with a very interesting category.
Модель логистической регрессии: влияние эндогенного уровня магния на концентрацию препаратов магния в исследовании биоэквивалентности
Authors: Еременко Наталья Николаевна , Ших Е. В. , Раменская Г. В.
Published: June 2023

Проведено исследование сравнительной биодступности и биоэквивалентности лекарственных препаратов, содержащих в составе цитрат магния, построены модели логистический регрессии для оценки влияния фонового содержания магния на концентрацию магния после применения препаратов. Оценивали следующие фармакокинетические параметры: Cmax — максимальная концентрация магния в цельной крови добровольца; tmax — время достижения максимальной концентрации магния в цельной крови добровольца; AUC(0-t) — площадь под фармакокинетической кривой «плазменная концентрация — время». Для корректного вычисления фармакокинетических параметров был предусмотрен пересчет с учетом эндогенного уровня магния. Установлено, что изучаемые препараты биоэквивалентны, рассчитанные значения 90 % доверительных интервалов находились в пределах допустимых значений 80 – 125 %. Построены модели логистической регрессии, где в качестве зависимой переменной было выбрано значение концентраций после приема изучаемых препаратов, а фактором влияния — значение фонового содержания магния. Корреляционная связь между значением «фон» и значением Cmax у добровольцев, принимавших исследуемый препарат и препарат сравнения, заметная и положительная (по шкале Чеддока) — соответственно 0,650 и 0,667, статистически значимая — соответственно p < 0,006 и p < 0,005; в полученной модели учтены соответственно 42,3 и 44,4 % факторов, определяющих изменения уровня Cmax. Сделан вывод, что построение модели логистической регрессии взаимосвязи фоновой концентрации магния и концентрации после приема изучаемых препаратов может рассматриваться как один из возможных предикторов, который можно использовать для оценки биодоступности препаратов, содержащих соли магния.
Фармакологическая коррекция метаболических и функциональных нарушений у пациентов при стенокардии
Authors: Дзугкоев Сергей Гаврилович , Дзугкоева Фира Соломоновна , Маргиева Ольга Ивановна , Хубулова Анна Елизбаровна
Published: June 2023

Изучено влияние фармакологической коррекции метаболических нарушений на параметры свободно-радикальных реакций, гомеостаза оксида азота и уровня холестерина у пациентов с ишемической болезнью сердца. В исследование было включено 80 пациентов с ишемической болезнью сердца и 30 относительно здоровых лиц. Пациенты разделены на 4 группы: контрольная (n = 30), 1 группа — пациенты на стандартной терапии (n = 20); 2 группа — стандартная терапия + ингибитор 3-кетоацил-КоА-тиолазы — триметазидин (n = 20); 3 группа — стандартная терапия + триметазидин и ингибитор ГМГ-КоА-редуктазы — аторвастатин (n = 20), 4 группа — комплексная терапия: триметазидин, аторвастатин и коэнзим Q10 (n = 20). Оценивая результаты исследования, отмечаем, что применение триметазидина снизило содержание малонового диальдегида на 8 %, аторвастатин уменьшил уровень общего холестерина на 9,3 %. Назначение триметазидина, аторвастатина, коэнзима Q10, в течение 3 месяцев на фоне стандартного лечения, вызвало позитивную динамику метаболических данных: снижение уровня малонового диальдегида в среднем на 26 % (p < 0,001) вследствие повышения активности супероксиддисмутазы и каталазы, соответственно на 80 и 38 %, а также повышение содержания основного вазодилататора — суммарных метаболитов оксида азота — на 65,8 %. Положительные изменения окислительно-восстановительных процессов сопровождались улучшением результатов ЭКГ-исследования: уменьшением эпизодов ST на 30 %, снижением глубины депрессии на 43 %, систолического и диастолического артериального давления на 13,9 – 14 %. Комплекс лекарственных средств (триметазидин, аторвастатин, коэнзим Q10) оказался эффективным для стимулирования процессов метаболизма и улучшения клинической картины заболевания.
Опыт применения циклоферона при заболеваниях репродуктивного тракта женщин под контролем коррекции микросимбиоценоза
Authors: Жеребятьева О. О. , Махалова Г. О. , Киргизова С. Б. , Азнабаева Л. М. , Михайлова Е. А. , Мирошниченко И. В. , Коваленко А. Л. , Миронов А. Ю.
Published: June 2023

Цель работы — микробиологическое обоснование применения циклоферона в лечении и профилактике заболеваний женского репродуктивного тракта, вызванных бактериальными возбудителями. Установлено, что циклоферон (меглюмина акридонацетат) оказывает модифицирующее действие на биологические свойства S. aureus и E. coli. Циклоферон в концентрации 50 мкг/мл ингибировал: биопленкообразование S. aureus в среднем на 21 %, E. coli — на 26 %, антилизоцимную активность — на 66 и 26 % соответственно, антикарнозиновую активность стафилококков — в среднем на 25 % (p < 0,05). Препарат вызывал восстановление состава микросимбиоценоза с элиминацией нехарактерных микроорганизмов — увеличение показателя частоты выделения Lactobacillus spp. (с 51,6 % случаев до лечения до 61,7 % после лечения) и Corynebacterium spp. (с 35,9 до 44,5 %) и уменьшение частоты высеваемости S. aureus (с 20,3 до 8,6 %), S. epidermidis (с 46,9 до 17,2 %), энтерококков (с 29,7 до 10,9 %), грибов рода Candida (с 20,3 до 10,9 %) и E. coli (с 46,9, до 18,7 % случаев), Pseudomonas aeruginosa (с 9,38 % до полного исчезновения). Эффективность циклоферона может быть связана с нормализующим эффектом на микробиоценоз слизистых оболочек и иммунокорригирующим действием, что делает актуальным дальнейшее изучение данного препарата для внедрения его в широкую клиническую практику.
Analysis of Problem-Based Learning Model on Mathematical Critical Thinking Skills of Elementary School Studentst
Authors: Harianja Robert , Tampubolon Taruly , Manalu Lamtagon
Published: June 2023

PBL is a learning model that leads to strengthening competence of problem-solving, critical reasoning, and learning about learning. The purpose of this study was to determine the significance of the effect of applying the PBL learning model on the critical thinking competence of sixth-grade elementary school students on circle material. The approach applied in this study is a quantitative approach with a pre-test and post-test critical thinking design type. Data collection techniques in this study used critical thinking tests. The participants who were included in this study were 25 students of class VI at SDN 173270, siborong – borong , north sumatera. Data analysis using a one-sample t-test. Based on the calculation of the hypothesis testing is done using the t-test.  The normality test results for the value of critical thinking results are 0.139 > ? (0.05) exceeding the significant value, then the variable values are normally distributed, followed by using the one-sample t-test, the t-test results on the equation of the variance section which are assumed to show the Sig value (2)-tailed) < ? ie 0.000 < 0.05 then reject H0. So it can be concluded that there is a significant effect of the application of PBL on the mathematical critical thinking skills of grade VI elementary school students.
PERFIL DOS ERROS DE MEDICAMENTOS POR SONDA ENTERAL EM TERAPIA INTENSIVA:
Authors: Lisboa Caroline de Deus , Silva de Andrade Karla Biancha , Camerini Flávia Giron , Henrique Danielle de Mendonça , Fassarella Cintia Silva , Nepomuceno Raquel de Mendonça , Ferreira de Almeida Luana , Galdino de Paula Vanessa
Published: June 2023

Objetivo: analisar os erros que ocorrem no preparo de medicamentos por sondas enterais em terapia intensiva. Método: estudo observacional, com desenho transversal, norteado pelas recomendações do Strengthening the Reporting of Observational Studies in Epidemiology (STROBE), realizado em quatro unidades de terapia intensiva de um hospital privado da cidade do Rio de Janeiro. Para avaliar o preparo de medicamentos na forma farmacêutica sólida as variáveis foram: trituração e diluição. Para os medicamentos líquidos somente a variável diluição. A unidade de medida utilizada para o cálculo amostral foi a dose preparada do medicamento, sendo analisadas 720 doses de medicamentos prescritos por sondas.  Foram observados 80 técnicos de enfermagem no momento de preparo dos medicamentos garantindo-se que o profissional fosse observado no manejo de no mínimo nove doses de medicamentos. Resultados: Foi identificado erro no preparo de 480 doses (66,66%). Os comprimidos revestidos e cápsulas de gelatina dura foram triturados indevidamente em 100% das doses analisadas e 54% dos comprimidos simples tiveram tritura insuficiente. A diluição insuficiente ocorreu em 100% das doses de xaropes. A tritura insuficiente para comprimidos simples ocorreu em 310 doses (54%). A diluição insuficiente ocorreu em 100% das doses de xaropes. O erro prevalente foi o de tritura para os medicamentos sólidos. Conclusões: o preparo de medicamentos apresentou uma frequência alta de erros, o que pode levar a perdas na biodisponibilidade do fármaco e comprometer as boas práticas da terapia medicamentosa por sonda enteral.
Skin Cellular Reprogramming as an Innovative Anti-Aging Strategy for Cosmetic Application: A Clinical Study of Sericoside
Authors: Meunier Marie , Bracq Marine , Tiguemounine Jean , Maramaldi Giada , Scandolera Amandine , Reynaud Romain
Published: June 2023

Background: While our body ages, skin cells progressively lose their pluripotency and proliferative capacities, as well as remodeling driver role, among other activities. This loss of capacities leads to visible aging signs such as wrinkles, under-eye bags or even aging spots. We studied if the stimulation of cell pluripotency and proliferation by a natural molecule could be an innovative anti-ageing strategy for skin rejuvenation. Methods: The activity of sericoside, a compound extracted from the bark of Terminalia sericea roots, was evaluated at a concentration of 0.02% in vitro. This assessment involved transcriptomic analysis on fibroblasts after 24 hours, as well as proliferation tests on aged fibroblasts after 72 hours. A clinical study was then conducted on 40 volunteers between the ages of 35 and 55. For four weeks, volunteers applied a cream twice daily containing either sericoside or blank emulsion (control group). Skin elasticity was measured by cutometry with R2 parameter. Skin texture and roughness was analyzed by an in vivo 3D scanner. Results: Transcriptomic analysis showed that sericoside improved the set of gene expressions involved in cell cycle (+85% MKI67), cell proliferation (+250% IGF1), DNA repair (+56% OGG1), pluripotency transcription factors (+36% NANOG) and stem cells maintenance (+200% SOX2). We substantiated a decrease of proliferation factor with aged cells compared to young cells by 50%, while sericoside increased this proliferation factor by +46%, a similar rate to that of a 22-year-old donor. Clinically, the anti-aging effects of sericoside were evident: the use of sericoside resulted in a 17% increase in skin elasticity and a 10% reduction in skin roughness, underscoring the smoothing effect with sericoside. Conclusions: The study highlighted an innovative anti-aging strategy that involves re-activating cells’ memory to reprogram cell pluripotency by stimulating the natural tools available in our DNA.
Exploring the Role of Vitamin D and the Vitamin D Receptor in the Composition of the Gut Microbiota
Authors: Aggeletopoulou Ioanna , Tsounis Efthymios P. , Mouzaki Athanasia , Triantos Christos
Published: June 2023

The microbiome has a major impact on human physiology and plays a critical role in enhancing or impairing various physiological functions such as regulation of the immune system, metabolic activities, and biosynthesis of vitamins and hormones. Variations in the gut microbial community play a critical role in both health and disease. Regulation of calcium and bone metabolism, as well as cellular functions such as proliferation, apoptosis, differentiation, and immune modulation, are among the known effects of vitamin D. These biological functions are primarily carried out through the binding of vitamin D to the vitamin D receptor (VDR), a member of the nuclear receptor superfamily. The immunomodulatory properties of vitamin D suggest that this molecule plays an important role in various diseases. Maintenance of immune homeostasis appears to occur in part through the interaction of the gut microbiota with vitamin D. Increasing evidence points to the central role of vitamin D in maintaining mucosal barrier function, as vitamin D deficiency has been associated with disruption of gut barrier integrity, translocation of bacteria into the bloodstream, and systemic inflammation. In parallel, a bidirectional interaction between vitamin D and the gut microbiota has been demonstrated as data show upregulation of intestinal VDR expression and downregulation of inflammatory markers in response to fermentation products. The aim of this review is to provide an overview of the evidence of a link between the gut microbiome and vitamin D, with a focus on data from experimental models and translational data from human studies related to vitamin D-induced changes in gut microbiota composition.
Non-Alcoholic Fatty Liver Disease, Atherosclerosis, and Cardiovascular Disease in Asia
Authors: Lim Yohwan , Jeong Seogsong , Hong Myunghee , Han Hyun Wook
Published: June 2023

The prevalence of non-alcoholic fatty liver disease (NAFLD) is estimated to increase to over half of the adult population by 2040 globally. Since the final diagnosis of NAFLD is made by a liver biopsy, several non-invasive approaches have been developed and validated to define NAFLD and evaluate NAFLD-associated diseases. Presently, NAFLD has been identified as an important and independent risk factor for developing several extrahepatic diseases, including atherosclerosis, cardiovascular disease (CVD), diabetes, and dementia. This review discusses current findings of up-to-date literature regarding the effects of NAFLD on the risk of atherosclerosis and CVD in Asia along with potential underlying biological mechanisms and therapeutic approaches to lower the NAFLD-related CVD risk. We further focus on the difference between NAFLD and metabolic dysfunction-associated fatty liver disease (MAFLD) on the risk of CVD and its implication by comparing the risk of NAFLD and MAFLD.
Prevention of Cardiac Implantable Electronic Device Infections: A Review
Authors: Sławiński Grzegorz , Kempa Maciej , Przybylski Andrzej
Published: June 2023

The importance of cardiac implantable electronic devices (CIEDs) in the treatment of cardiac rhythm disturbances, heart failure, and the prevention of sudden cardiac death is indisputable. However, CIED therapy is associated with complications, among which infections are particularly unfavourable in terms of prognosis. The diagnosis and management of CIED infections remain complex, with a significant impact on mortality and healthcare costs. For these reasons, the risk factors for CIED infections and methods of their prevention have been assessed in recent years. This review summarises the current state of knowledge on the subject. We also outlined the role of alternative methods, such as subcutaneous defibrillators, leadless pacemakers, and wearable cardioverter defibrillators.
A Psychoanalysis Study: Psychopath Personality Disorder Of The Main Character From The Movie “Orphan: First Kill” (2022)
Authors: Zahira Raisya Ghina , Simanjuntak Abel Halomoan , Ummah Fajrin Izzatul , Adjie Bagas Respati , Setiyowati Diyah , Hermawan Nada Anjani Putri
Published: June 2023

This Research aims to analyze the psychoanalysis of a female character from The Orphan: The First Kill (2022) named Leena as a psychopathic problem character. This Research uses Sigmund Freud’s theory that all people have unconscious thoughts, memories, emotions, and desires and that therapy should be used to access the mind's repressed feelings and experiences. The research uses descriptive qualitative methodology to describe the intrinsic and extrinsic elements of the movie, such as the conversation and scenes, which are then subjected to Sigmund Freud's psychoanalysis as the movie's extrinsic component. The author discloses specifics of the psychopathic character and the causes of it through observations of the scenes and dialogues in that the filmmaker delivers Esther's characterizations as the primary character of Orphan. The purpose of this study is to determine the factors that support the behavior shown by Esther as the main character.
UAS ILMU POLITIK DAN PENDIDIKAN IPS
Authors: Ramadhani Muhammad Aqiela
Published: June 2023

1. Mengapa kekuasaan diperlukan untuk mempengaruhi kebijakan politik. Uraikan bagaimana pendapat Anda. 2. Jelaskan menurut pandangan anda tentang perkembangan Dinamika Demokrasi yang ada di Indonesia. 3. Uraikan bagaimana hubungan antara politik dengan pendidikan. 4. SIlakan pilih 1 tulisan di google scholar MZA Anis Anis dan Muhammad Adhitya Hidayat Putra (masing-masing 1), kemudian kutip dan korelasikan dengan materi politik disertakan contoh konkrit! 5. Sebutkan dan Jelaskan sejarah etika protestan menurut anda dan sertakan sumber.
CHANGES IN THE BEHAVIOR OF STUDENTS (CASE STUDY OF ALUMNI OF AN-NAHDLIYYAH BOARDING SCHOOLS IN BANYUPUTIH VILLAGE, BANYUPUTIH DISTRICT, BATANG DISTRICT)
Authors: Nida Fitrotun
Published: June 2023

This research discusses changes in the social behavior of students at the an-Nahdliyyah Banyuputih Islamic Boarding School using the Behavioral theory of BF Skinner, a well-known American psychologist from the flow of behaviorism. Skinner explained that social behavior change is not entirely influenced by the social paradigm but rather by the interaction between stimulus and response. The essence of Skinner's thought is that every human being moves because he gets stimulation from his environment. The system is called operant conditioning or "determining the way of working."The students at Islamic boarding schools are educated with discipline, habituation of obedience to worship, and good manners towards parents, teachers, and friends. However, when they return to the community, many changes in behavior are not by Islamic rules and those taught in Islamic boarding schools. This change in the student's behavior interested the researchers, so they studied more deeply, and Pondok an-Nahdliyyah Banyuputih was made the object or focus of research. The research method used is a qualitative method with a descriptive approach. As for the technique of collecting data through the interview method so that the data source is obtained through informants; observation method, researchers make in-depth observations in the environment. Results of researchThis researcher can conclude that changes in the behavior of an-Nahdliyyah students are due to the compulsion to attend Islamic boarding schools which, in the end, when they return home, they feel free to do anything, always follow trends on social media regardless of good or bad and graduates of the age of students who are still teenagers. Hence, it is easy for them to be influenced by the environment.
Pengaruh Jenis Kelamin dan Jumlah Pengeluaran Modal Terhadap Pendapatan UMKM
Authors: Putri Defita Aulia Aryn , Nurpaujiah Neng Inka Najila , Ni'mah Liza Tazkiyatin , Susanti Titi , Nasrullah Mochamad Fadhyl , Fanani Muhammad Fadhil , Rosyada Muhamad Alfin , Guna Bayu Cakra , Aulia Keysha Fitri
Published: June 2023

Micro, Small and Medium Enterprises (MSMEs) play an important role in the economic development of a country. This study aims to analyze the effect of gender and capital management on MSME income. The data used in this study were collected through a survey of 30 SMEs in the area of IAIN Syekh Nurjati Cirebon. Regression analysis was used to examine the relationship between the independent variables (gender and management capital) and the dependent variable (MSME income). The results showed that gender did not have a significant effect on MSME income. Meanwhile, capital expenditure has an effect on MSME income.
Pro-Environmental Behavior and Actions: Review of the literature and agenda for future research
Authors: Zehui Zhao
Published: June 2023

This article critically examines the existing literature on pro-environmental behavior, focusing on essential theories, empirical evidence, and cross-disciplinary implications. The study delves into the influence of individualistic, societal, and circumstantial factors in shaping pro-environmental behaviors, drawing insights from prominent theoretical models. Moreover, it thoroughly examines the effectiveness of economic incentives and non-market approaches in stimulating pro-environmental activities, emphasizing the need for integrating behavioral economics and social psychology within the field of environmental studies. The paper concludes by identifying potential areas for future research, including the role of digital technologies, climate change communication, and social networks in fostering sustainable societies. The primary objective of this study is to equip researchers and practitioners with the necessary knowledge to develop effective strategies for promoting sustainability.
Trial and error as an explanation for the illusion of moral decline. Response to https://www.nature.com/articles/s41586-023-06137-x
Authors: Baciu Dan Costa
Published: June 2023

On June 7, 2023, Nature has published the article “The illusion of moral decline” by Mastroianni and Gilbert. The article substantiates that people believe in moral decline, and it reconfirms that this belief may be an illusion. The evidence provided is partly archival and partly experimental. To explain why the belief in moral decline is so pervasive although it may be an illusion, the authors furthermore propose a new theory based on two types of psychological bias (biased exposure to information and biased memory for information). The authors hasten to state that their theory provides at best one possible explanation, thus opening a debate on other potential explanations. In my present response to this Nature article, I would like to add another explanation based on common properties of evolutionary processes. My explanation does not require psychological bias. The only thing that one needs to assume is that human culture, like biological evolution, advances through a process of trial and error. Because this processes is a process of trial and error, people perceive that there is plenty of error, which makes them falsely extrapolate that their culture is in decline, overall. As a matter of fact, success is rare, and its impact is easily overlooked. Thus, the people and the media do not necessarily need to be biased for the illusion of cultural define to emerge. My theory—initially published before the new experimental data were collected—can explain both a broad array of past empirical observations as well as the new experimental data.
Ujian Akhir Semester Ilmu Politik dan Pendidikan IPS
Authors: Faisal Achmad Reza
Published: June 2023

Ujian Akhir Semester Ilmu Politik dan Pendidikan IPS
UAS Politik_Muhammad Nur Hidayat_2210128210028
Authors: Hidayat Muhammad Nur
Published: June 2023

1. Mengapa kekuasaan diperlukan untuk mempengaruhi kebijakan politik. Uraikan bagaimana pendapat Anda.2. Jelaskan menurut pandangan anda tentang perkembangan Dinamika Demokrasi yang ada di Indonesia.3. Uraikan bagaimana hubungan antara politik dengan pendidikan.4. SIlakan pilih 1 tulisan di google scholar MZA Anis Anis dan Muhammad Adhitya Hidayat Putra (masing-masing 1), kemudian kutip dan korelasikan dengan materi politik disertakan contoh konkrit!5. Sebutkan dan Jelaskan sejarah etika protestan menurut anda dan sertakan sumber.
UAS POLITIK
Authors: Nirwikira Putu Pusya
Published: June 2023

1. Mengapa kekuasaan diperlukan untuk mempengaruhi kebijakan politik. Uraikan bagaimana pendapat Anda.2. Jelaskan menurut pandangan anda tentang perkembangan Dinamika Demokrasi yang ada di Indonesia.3. Uraikan bagaimana hubungan antara politik dengan pendidikan.4. Silakan pilih 1 tulisan di google scholar MZA Anis Anis dan Muhammad Adhitya Hidayat Putra kemudian kutip dan korelasikan dengan materi politik disertakan contoh konkrit!5. Sebutkan dan Jelaskan sejarah etika protestan menurut anda dan sertakan sumber
Statistika; Aplikasi Dalam Penelitian Manajemen
Authors: Layaman Layaman
Published: June 2023

Buku ini dilatarbelakangi oleh keresahan mahasiswa dalam menyusun tugas akhir. Mereka belum memahami aplikasi Mta Kuliah Statistika secara komprehensif. Buku ini disusun berdasakan teori-teori statistika disertai dengan contoh aplikasi dalam penelitian seperti Regresi Linear Berganda, Analisis Jalur serta penelitian yang menggunakan model berstruktur
Pengaruh Persepsi Harga dan Kualitas Pelayanan terhadap Loyalitas Pelanggan melalui Kepuasan Pelanggan pada E-commerce Shopee (Studi Kasus Mahasiswa/i Jurusan Ekonomi Syariah IAIN Syekh Nurjati Cirebon)
Authors: Nugraha Dea , Hilda Muhamad , ayunda Retno , Yuliana  , nurlailasari Euis , Khadafi Ni'mal Maula , Auliyah Vira , nur'aini Esa
Published: June 2023

The purpose of this research is to determine the effect of perceived price and service quality on customer loyalty through customer satisfaction on Shopee e-commerce. The most important thing in the business world is the concept of customer satisfaction which is used to attract consumers. It is the company’s obligation to provide the best quality service in order to survive and remain trusted. Creating customer satisfaction can provide benefits including the relationship between the company and the customer to be harmonious, and customers will make repeat purchases so as to create customer loyalty. This study uses quantitative methods based on primary data sourced from distributing questionnaires. The population in this study are students majoring in Islamic economics at IAIN Syekh Nurjati Cirebon class of 2021 who have made transactions on e-commerce Shopee with a sample that has been calculated using the slovin formula, namely 72 students. And data analysis techniques in this study using a path analysis model (path analysis) assisted by using the application SPSS (Statistical Product and Service Solutions). The result of this research is that there is an effect of price on customer satisfaction. This shows that the better the quality of service provided by the Shopee team to the customer team, the more satisfied consumers make purchases at Shopee and will increase the satisfaction of Shopee customers.
SOCIAL DYNAMICS IN THE DIGITAL ERA: A CASE STUDY OF SOCIAL INTERACTION AND CULTURAL CHANGE IN SOCIAL MEDIA
Authors: Sada Maksum
Published: June 2023

This study aims to analyze the influence of social media on social solidarity and community cohesion. Through a literature study approach, the author investigates how the dynamics of social relations in social media influence patterns of social interaction, changes in culture and values, social structures, the formation of individual identities, social change, and social solidarity and community cohesion. The findings of this study indicate that social media has the potential to strengthen social solidarity and community cohesion through increased access to information, open dialogue, and collaboration in social movements. However, the unwise use of social media can exacerbate social polarization, conflict, and division. Therefore, it is important to increase media and digital literacy, promote inclusive dialogue, select positive content, and implement appropriate policies to optimize the impact of social media on social solidarity and community cohesion.