bluuebunny/crossref_metadata_2025 huggingface dataset:
Neural Network Modelling of Phenolic Content, Antioxidant Capacity and Microbial Population Dynamics of a Household Scale Spontaneous Fermentation of Carica Papaya Leaf
Authors: So’aib Mohamad Sufian
Published: October 2023

Beneficial effects of spontaneous fermentation on Carica papaya leaf (CPL) have been observed in terms of enhanced total phenolic content and antioxidant capacity, as well as cultivation of lactic acid bacteria (LAB). Nonetheless, these responses were nonlinear, thus Artificial Neural network (ANN) was used as a predictive tool. The chosen ANN architecture consisted of multi-layer perceptron (MLP) with 2-7-7-1 and 2-10-10-1 topologies,Levenberg-Marquardt training algorithm, and hyperbolic tangent sigmoid activation function. Enhanced total phenolic content (TPC) and antioxidant capacity were recorded in final CPL extracts (day 90) of 5-L fermenter origin; 48.42±0.31 mg GAE/g dm and 467.38±4.09 mM TE/g dm, respectively, as compared to 12.13±0.39 mg GAE/g dm and 275.46±3.09 dm of respective extracts at initial (day 0). Likewise, enhanced total phenolic content (TPC) and antioxidant capacity were also observed for 50-L fermenter origin extracts. The chosen ANN topologies displayed the highest predictive ability as indicated by their correlation coefficient (R) of greater than 0.9, the marginal difference in mean square error (MSE) between training and testing data sets, and the absolute average deviation (AAD) of less than 10% between the predicted and experimental values of most responses. In conclusion, ANN was a reliable predictive tool for nonlinear responses during spontaneous fermentation of CPL.
The indigenous species of predatory mites (Acari: Phytoseiidae) as biological control agents of plant pests in Slovenia
Authors: Novljan Monica , Bohinc Tanja , Kreiter Serge , Döker Ismail , Trdan Stanislav
Published: October 2023

Phytoseiid mites are of great importance for the biological control of spider mites, thrips, and whiteflies. In this article, we present six species of predatory mites from the family Phytoseiidae, which are included in the list of indigenous organisms for biological control in Slovenia. These species are Amblyseius andersoni, Neoseiulus californicus, N. barkeri, N. cucumeris, Euseius gallicus, and Typhlodromus pyri. Being included in the list mentioned above, these species have great potential to be used in biological control and are technically qualified sources for the management of several pest species in agricultural production in Slovenia. Detailed information about the feeding habits, food preferences, and biological control potentials of these species is presented herein.
Predictors of anemia without active bleeding signs in patients referred for endoscopy
Authors: Munteanu Sabrina Nicoleta , Cozac-Szőke Andreea Raluca , Mocan Simona , Zait Tania Mihaela , Rus Răzvan Iacob , Petri Răzvan Emil , Negovan Anca
Published: October 2023

Objective: The objective of the present study is to clarify the value of clinic, endoscopic, and histologic variables that may predict anemia in patients performing esophagogastroduodenoscopy for gastrointestinal complaints in the absence of bleeding signs or lower digestive disease.

Methods: This study included 654 patients referred for endoscopy that were divided based on biological parameters performed in the same day in the study group (306 patients diagnosed with anemia) and the control group (348 patients without anemia).

Results: Anemia is frequent in elderly patients, especially in the presence of premalignant gastric lesions, and it is associated with multiple comorbidities. In two multivariate regression models antivitamin K oral anticoagulants were found to be independently associated with anemia (p = 0.01), but not with antiplatelet therapy, or with non-antivitamin K anticoagulants. Multiple regression models support that epigastric pain and heartburn are inversely associated with anemia, while weight loss remained an independent predictor for simultaneous anemia and premalignant lesions. Non-infectious chronic gastritis (p<0.001) is an independent predictor for anemia and premalignant gastric lesions, increasing the odds of anemia by 2.2 times, while reactive gastropathy is inversely associated. Gastric erosions and ulcer remained independent predictors for concomitant anemia and premalignant lesions.

Conclusions: Chronic inactive gastritis and premalignant gastric histologic lesions are predictors for anemia in endoscopic population, while active H. pylori infection is not. Dyspeptic symptoms, epigastric pain (p<0.001,OR 0.2-0.5) and heartburn (p<0.001,OR 0.07-0.3) are inversely associated with anemia alone or associated with premalignant gastric lesions.
Microscale iron spherules as a trace of metallurgical activity in Old-Polish Industrial District river valleys
Authors: Kalicki Tomasz , Przepióra Paweł , Kusztal Piotr , Fularczyk Karolina , Houbrechts Geoffrey
Published: October 2023

In the last few centuries, a metallurgical industry based on forges driven by water wheels developed in many European valleys. One such area is the Old-Polish Industrial District (OPID) in Central Poland, which is one of the largest of this type of industrial center. Metallurgical activity developed here from the Prehistoric to modern times. The transformation of metallurgical technology led to the collapse of production, and the ongoing renaturation obliterated most of the traces of former industrial activity. The Magnetic Spherule Separation method used so far in Western Europe, and recently in Poland, has been able to detect traces of former metallurgical activity preserved in alluvium. Fluvial deposits contain microscopic, perfectly spherical iron hammerscales formed during metallurgical production. The results of the study of the alluvium of selected rivers in the OPID indicate the presence of iron spherules of various origin and facies in the sediments of the floodplain, which accumulated during the period of metallurgical activity and were redeposited in modern times. This allows us to estimate, among other things, the age, rate of accumulation and impact of anthropopressure on sedimentation conditions.
European Union Funds as Stimulators of Sustainable Tourism Development in Municipalities of the Lower Silesian Region in Poland in 2014-2019
Authors: Puciato Daniel , Oleśniewicz Piotr
Published: October 2023

Introduction.
The study assessed the impact of EU funds on sustainable tourism in the Lower Silesian region of Poland in the years 2014-2019.

Material and methods.
A literature review and the following research methods were used in the study: logical analysis and construction, as well as documentary and statistical analyses. A database was compiled containing statistical data on implemented tourism projects subsidized with EU funds in municipalities of Lower Silesia. Each project was then assigned to one of sustainable tourism sections in accordance with the Global Sustainable Tourism Council Destination Criteria. Statistical analysis included structure analysis, basic statistics, and the Kruskal-Wallis ANOVA test and post-hoc test.

Results.
The Kruskal-Wallis test results (H = 20.01 for project values, and H = 23.34 for the amount of EU funding) and the probability level (p = 0.001) demonstrated that project expenditures on tourism in each sustainable tourism section differed significantly. The multiple comparisons test (post-hoc test) revealed statistically significant differences between the values of projects implemented in the sections of cultural sustainability and sustainable management (p = 0.009), cultural sustainability and environmental sustainability (p = 0.009), socio-economic sustainability and sustainable management (p = 0.009), and socio-economic sustainability and environmental sustainability (p = 0.008). In terms of the amount of EU funding, statistically significant differences were found between cultural sustainability and environmental sustainability (p = 0.001), and socio-economic sustainability and environmental sustainability (p = 0.001).

Conclusions.
The allocation of EU funds for tourism projects did not contribute to the implementation of sustainable tourism. In the next EU programming period, i.e. 2021-2027, a more sustainable allocation of funds for tourism projects should be pursued. There is a clear need to increase the number and value of tourism projects implemented in the area of environmental sustainability.
Philosophy of Culture on the Philosophy of Modern Education in China
Authors: Yonghong Cai , Fomina M. N.
Published: October 2023

In Chinese philosophy, modern processes of searching for the fundamental values of the renewed strategies of education are based upon traditional Confucian approaches as well as upon recent borrowings from Western philosophy. The concept of philosophical dialogue is one example of these borrowings, adopted and radically changed following traditional Chinese logic. Such transformation means adapting the theoretical model of Socrates’ dialogue into Confucian dialogue, the term coined by Chinese authors. This paper considers Chinese developments in the philosophy of culture and aims to specify the ways of such adaptation as applicable to the philosophy of education. The goals of the study are 1) to identify and describe relevant Chinese literature on the subject; 2) to compare its interpretations by Chinese and Russian philosophers; 3) to specify key differences in interpretations of dialogue as educational method. Investigating the issue through philosophical and cultural lens, incorporating the standpoint of modern comparative studies, as well as the critical analysis of the logic of those theories in their historical and cultural context by means of the hermeneutic approach makes it possible for Chinese authors to focus on the cultural peculiarities of the Chinese way of thinking and to identify the correlation between the Western concept way of thinking and the concept of Chinese logic. This study analyzes the works of modern Chinese philosophers specializing in the specific cultural character of China through the prism of the philosophy of education. The paper concludes that in Chinese logic technical (in the Western understanding regarded as cognitive and formal logical) methods are inferior to ethical and social value orientations. Another finding is that Chinese authors tend to consider Confucian logic as part of dialogue, and dialogue is viewed as a means of moral education. Methodologically this finding leads the author to suggest that the Chinese-specific way of thinking, its philosophical culture, cannot be fully perceived by utilizing comparison with analogous concepts of Western philosophical thought. It would be equally beneficial to compare the conceptual framework of the Chinese philosophy of education with the concepts borrowed from Western philosophy.
Representation of Christmas Praises of Russian Lipovans of Romania on the Internet
Authors: Ezhova O. F.
Published: October 2023

This article is the first attempt to study the representations of Christmas slavleniya (praises) of the Russian Lipovans of Romania on social networks. The Russian Lipovans of Romania are a community of Russian Old Believers living on the territory of Romania mainly in the regions of Dobruja and Tulcea. Lipovans have cultural peculiarities, specific customs, and practices, one of which is Christmas glorification, consisting of singing fragments of the Christmas Church Service of the Old Believers. A similar custom is also observed among the Russian Old Believers of Moldova and Ukraine. Currently, members of the Russian Lipovans community of Romania have been recording the praises taking place in homes or public places on video and posting them on social networks and on various Internet platforms. The relevance of the topic is related to the need to study the impact of new technologies on the maintenance and distribution of traditional culture, which is especially important for small communities. The purpose of the article is to highlight and analyze the characteristic features of the representation of Christmas greetings of the Lipovans of Romania on the Internet. Accordingly, the following tasks have been identified: 1) consider the influence of historical circumstances on the formation of traditional culture of Christmas celebrations by the Old Believers of Romania; 2) collect and describe examples of the representation of Christmas praises of the Russian Lipovans of Romania on the Internet and analyze the specifics and the socio-cultural context of their existence; 3) highlight the key features of this practice compared to similar customs of the Old Believers of Moldova and Ukraine. The research methodology was compiled by a comprehensive cultural approach based on the use of historical-genetic, hermeneutic, and comparative-analytical methods, as well as cyberethnography approaches. The study has found that the Russian Lipovans of Romania living in a different ethnic and confessional environment actively represent on their pages in social networks and private channels on YouTube the tradition of Christmas praises that exists in their community, which partly contributes to its reproduction and reconstruction. The results have enabled the author to conclude that the praises of the Lipovans of Romania, colindă, should not be confused with Christmas carols as they closely follow the canon and represent both a well-preserved variation of home worship and a specific practice of communication.
Efek Hipoksia Sistemik Kronik Terhadap Aktivitas Spesifik Enzim Kreatin Kinase Otot Rangka Tikus
Authors: Mudjihartini Ninik , Harmelia Dwi , Widia AJ Sri
Published: October 2023

Latar Belakang: Hipoksia adalah hasil dari ketidakseimbangan antara suplai oksigen dan kebutuhan oksigen. Pada kondisi hipoksia, otot rangka dituntut untuk menghasilkan ATP dalam jumlah yang cukup untuk mempertahankan fungsi kontraksi dengan O2 yang terbatas. Beberapa penyakit terkait penuaan sering disertai dengan kondisi hipoksia, demikian juga penyakit yang disebabkan oleh kelainan jantung dan paru. Hipoksia kronik sering terjadi pada populasi lanjut usia oleh karena cedera iskemik yang menginduksi sejumlah respons adaptif terhadap lingkungan mikro selnya. Tujuan: Penelitian ini untuk melihat bagaimana fenomena perubahan metabolisme salah satu sumber energi pada otot rangka pada kedaan hipoksia sistemik kronik, dengan mengukur aktivitas spesifik CK dan kadar kreatinin otot rangka pada tikus. Metode: Tikus hipoksia dibuat dengan cara memasukkan tikus ke dalam hypoxia chamber yang dialiri campuran gas oksigen 10% dan nitrogen 90%. Aktivitas spesifik CK diukur secara spektrofotometri menggunakan kit Creatine kinase N-acetyl-L-cysteine (Randox®), kadar kreatinin dengan metode Folin, sedangkan protein total otot tikus diukur dengan metode Christian-Warburg. Hasil: Aktivitas spesifik CK otot tikus kelompok 1H, 3H, 5H, 7H, dan 14H menurun secara bermakna dibandingkan dengan kelompok K (Kruskal-Wallis) (P<0,05). Kadar kreatinin otot tikus kelompok 1H dan 14H menurun secara bermakna dibanding dengan kelompok K, sedangkan kelompok 3H, 5H, 7H  meningkat secara bermakna dibanding dengan kelompok K (Kruskal-Wallis) (P<0,05). Simpulan: Hipoksia sistemik kronik menyebabkan penurunan aktivitas spesifik CK otot tikus semua kelompok dibanding kontrol. ATP untuk membentuk kreatin fosfat menurun menyebabkan kreatin bebas meningkat. Hasil oksidasi kreatin bebas menjadi kreatinin meningkat terlihat pada kelompok 3H, 5H, dan 7H.
Gambaran Kepuasan Lansia Terhadap Kualitas Pelayanan Kesehatan Poli Lansia Puskesmas Ciputat Kota Tangerang Selatan Tahun 2022
Authors: Larasati Rahma Ayu , Safitri Diniyah
Published: October 2023

Latar Belakang: Harapan pasien lanjut usia (lansia) saat datang ke pelayanan kesehatan adalah mendapatkan kepuasan pelayanan yang diterima, sehingga akan menjadi tolak ukur dalam pelayanan kesehatan serta berupaya untuk meningkatkan kebutuhan segala aspek mutu kesehatan pada lansia. Tujuan: Penelitian ini bertujuan untuk mengetahui gambaran kepuasan lansia terhadap kualitas pelayanan kesehatan poli lansia Puskesmas Ciputat Kota Tangerang Selatan tahun 2022. Metode: Penelitian ini merupakan penelitian kuantitatif deskriptif. Subjek penelitian yaitu lansia (>60 tahun) menggunakan instrumen penelitian berupa kuesioner dan wawancara langsung kepada responden. Hasil: dari total 50 responden, didapatkan hasil kepuasan pasien lansia yang berkunjung di poli lansia merasakan puas sebesar 41 orang (82%). Selanjutnya kualitas pelayanan kesehatan dengan metode servqual dilihat dari 5 dimensi yaitu dimensi bukti fisik (tangibles) memuaskan adalah 44%, dimensi kehandalan (reliability) memuaskan adalah 48%, dimensi ketanggapan (responsiveness) adalah 52%, dimensi jaminan (assurance) memuaskan adalah 48%, dan dimensi empati (empathy) memuaskan adalah 50%. Berdasarkan kualitas pelayanan Kesehatan secara keseluruhan didapatkan pasien lansia merasakan kurang memuaskan sebanyak 66%. Simpulan: Responden pada penelitian ini mayoritas merasakan puas saat berobat di Puskesmas dan merasakan kurang puas terhadap pelayanan kesehatan apabila dilihat dari keseluruhan dimensi, namun pada penilaian tiap dimensi, responden merasakan puas terhadap kunjungan di Puskesmas Ciputat Kota Tangerang Selatan.
The Effects of Inaccessibility of Sanitary Pads on High Illiteracy Levels for Girls in Public Primary Schools in Njoro Sub-County, Kenya
Authors: Alice Wambui
Published: October 2023

The purpose of the study was to investigate the effects of the inaccessibility of sanitary pads on high illiteracy amongst girls in primary schools in Kenya, Njoro sub-county. The research study was conducted under these:

To examine the provision of sanitary pads for girl's high illiteracy in public primary schools,

To examine the contribution of sanitary pads towards deviant behavior on girl's high illiteracy in public primary schools,

To examine how sanitary pads influence self-esteem on high illiteracy of girls in primary schools and

To examine how sanitary pads influence peer relations on the high illiteracy of girls in primary schools in Njoro Sub-County.

A literature review on menstrual health for girls and high illiteracy was used as the foundation of the study in relation to past studies. The study was founded on Structural Functionalist Theory on social systems and the family and school structures. The study adopted a Descriptive research design. The target population was 18131, while the sample generated using Naisssuma's (2000) sample formula was 99 respondents comprising teachers and pupils. Data analysis involved the use of descriptive and inferential statistics for quantitative data. Qualitative data were analyzed thematically and presented in direct narrative form. The study found that:

The influence of the provision of sanitary pads and high illiteracy had a strong correlation effect (r=0.781) which was significant at (p-value 0.12),

The inaccessibility of sanitary pads and deviant behavior had a below-average association (r=0.451) which was significant at (p~value 0.033),

The influence of sanitary pads and self-esteem for pubescent girls had a moderate positive relationship (r=0.55) which was significant at p-value (0.011) and

The influence inaccessibility of sanitary pads and peer influence (r=0.52), which was significant at (p-value 0.010).

The study concluded that the inaccessibility of sanitary pads has hampered class progress for girl children during their menstruation period, especially in places where pupils are not provided with adequate sanitary pads. Adversely, a lack of sanitary pads has significantly contributed to deviant behavior, especially in early pregnancies. However, the lack of sanitary pads causes lower self-esteem in the girls, which makes girls have low confidence during the learning process.
Studi Pemanfaatan Kotoran Sapi Sebagai Sumber Biogas di Nagari Aie Tajun Kecamatan Lubuk Alung Kabupaten Padang Pariaman
Authors: Putri Renny Eka , Andasuryani Andasuryani , Pratiwi Intan
Published: October 2023

Biogas adalah gas yang dihasilkan melalui proses anaerobik bahan organik dalam digester atau bak penampung menjadi energi. Energi yang dihasilkan dapat digunakan sebagai pengganti minyak tanah atau gas elpiji untuk memenuhi kebutuhan sehari-hari seperti memasak. Nagari Aie Tajun merupakan daerah dengan mayoritas bermata pencaharian petani dan peternak. Para peternak memiliki sapi setidaknya 3-4 ekor sapi, tapi hampir tidak ada yang memanfaatkan kotoran sapi sebagai sumber energi melainkan hanya dibuang begitu saja. Tujuan penelitian ini adalah untuk untuk mengatasi masalah kotoran sapi yang belum digunakan oleh petani sebagai biogas. Penelitian dilakukan dalam beberapa tahapan, meliputi pembuatan instalasi biogas, uji teknis terhadap biogas dan pendampingan terhadap masyarakat. Berdasarkan hasil penelitian didapatkan bahwa gas sudah mulai terbentuk pada hari ke 15 dan maksimum pada hari ke 21 dengan ditandai dengan menggelembungnya digester dan keluarnya bau khas kotoran sapi. Pengisian kotoran sapi ke dalam digester perlu dilakukan minimal setiap dua sampai tiga hari sekali dengan kotoran sapi sebanyak 20 - 30 liter. Biogas yang dihasilkan telah dapat dimanfaatkan untuk memasak sehari-hari oleh masyarakat setempat.
Apakah Pendidikan Lingkungan Merupakan Faktor Utama Pembentuk Perilaku Lingkungan pada Masyarakat di Negara Berkembang?
Authors: Ulhasanah Nova -
Published: October 2023

Environmental education in developed countries is currently being intensively developed to increase the environmental awareness of the community in order to achieve sustainable development. But for developing countries like Indonesia, is environmental education the most urgent thing to do first to improve the successful implementation of environmental management system? This paper presents an analysis of social aspects related to the environmental behavior of a society, which is about the importance of the "environmental education" factor for people in developing countries in general, in Indonesia specifically. In addition, other factors that form the environmental behavior of the community and their relationships with one another are also discussed. The topic chosen to represent environmental behavior in this paper is the community's environmental awareness for the waste management system in Padang, West Sumatra, Indonesia. This study uses structural equation modeling (SEM) (which consists of exploratory factor analysis (EFA) and confirmatory factor analysis (CFA)) to investigate the environmental behavior of the community represented by 609 respondents living in the Padang city. The results of the study show that environmental education factor is ranked 3rd out of 8 determinants of the formation of environmental behavior in society, namely after the factors of "government role" and "law enforcement". This research is expected to be able to provide information to various stakeholders where providing environmental education to the community has not been able to effectively change the environmental behavior of the community if the government's role in making a good environmental management system and strong law enforcement have not been carried out.
Analisis Konsentrasi PM2,5, CO dan CO2 di Dalam Ruangan Akibat Penggunaan Kompor Biomassa Berbahan Bakar Briket Tempurung Kelapa dan Briket Kayu Bakar
Authors: Goembira Fadjar , Nazir Afifah , Husna Amalia , Ihsan Taufiq
Published: October 2023

The objective of this study was to analyze the concentration of PM2.5, CO and CO2 indoor due to the use of biomass stoves and to calculate the value of combustion efficiency and fuel use efficiency in biomass stoves. The test was conducted by the water boiling test method to simulate the cooking process that was divided into 3 phases. The fuel used was coconut shell briquettes and firewood briquettes. Based on the test results the obtained concentration of PM2.5 from the the use of coconut shell briquette was 21.03 Âµg/Nm3 during the cold start phase, 23.66 Âµg/Nm3 in the hot start phase, and 15.57 Âµg/Nm3 in the simmering phase. As for Firewood briquette, it had lower PM2.5 concentrations, i.e., 17.17 Âµg/Nm3 in the cold start phase, 20.63 Âµg/Nm3 in the hot start phase, and 12.17 Âµg/Nm3 in the simmering phase. The results of CO concentration measurement in coconut shell briquette for the cold start, hot start, and simmering phases were 4.57; 4.32 and 5.27 ppm, respectively, and for firewood briquette were 3.92; 3.69 and 4.61 ppm, correspondingly. While for CO2 concentration measurements, for coconut shell briquette at cold start, hot start, and simmering phases were 376.83; 364.56 and 443.11 ppm, respectively, and for firewood briquette were 397.4; 383.61 and 486.45 ppm, accordingly. The concentration of PM2.5, CO and CO2 did not exceed the indoor air quality standard regulated by the Minister of Health Regulation No. 1077 of 2011 which is 35 Âµg/Nm3 for PM2.5, 9 ppm for CO and 1,000 ppm for CO2. The ratio of the biomass stove CO / CO2 briquette fuel was below the value of 0.02 which means that the combustion process occurred perfectly. The efficiency value of coconut shell briquette combustion was lower than that of firewood briquette combustion which is influenced by heating value, water temperature, the amount of fuel used and the length of the testing process, while the efficient use of fuel from using briquettes was better than biomass stoves made from unprocessed/raw biomass fuels.
ANALISIS BEBAN EMISI KENDARAAN DI GERBANG MASUK JALAN-JALAN ARTERI KE KOTA JAMBI
Authors: Handika Rizki Andre , Rodhiyah Zuli , Fitrada Wathri , Sari Annisa Purnama
Published: October 2023

The City of Jambi has three entering gateways for people from other places to get in using arterial roads. Two roads link Jambi City with South Sumatera, West Sumatera and also Riau Provinces, and one another connects to West Tanjung Jabung and East Tanjung Jabung Regencies. Many vehicles, starting from individual cars and motor cyclesuntil HDV with more dimensions such as trailer truck, have increased air pollution and would generate effect to human health. The research aimed to estimate the load emission from mobile sources on those gateways using Mobilev 3.0 software, and converted the results using Microsoft Excel for advance analysis. Data input came from the number of vehicles from General Sudirman Street, West Ring Road, Surya Dharma Street, South Ring Road, East Ring Road, and Yos Sudarso Street which was enumerated by direct observation using traffic counting method. The results showed that the highest emission (ton/year) to CO and HC was from General Sudirman Street and for CO2, NOx, PM10, and soot was from South Ring Road. The total average daily traffic (ADT) was 435,684.30 units of vehicles per 24 hours, which the biggest was in General Sudirman Street with 114,451.30 units of vehicles per 24 hours. Through this research, both the emission load and also the traffic load situation in each road could be described and became the important information on road transportation management related to ambient air pollution and greenhouse gases controlling.
Potensi Emisi Gas Rumah Kaca dari Pengolahan Air Limbah Domestik di Instalasi Pengolahan Air Limbah (IPAL) Bojongsoang, Kabupaten Bandung
Authors: Novia Fanny
Published: October 2023

Greenhouse gas emissions potential of CH4 and CO2 from domestic wastewater treatment at WWTP Bojongsoang are emitted from wastewater treatment process in anaerobic pond, facultative pond and maturation pond each on Set A and Set B. Emission factor of CH4 and CO2 are based on IPCC standard and the value depends on type of treatment. Greenhouse gas as CO2e emission from each stage on Set A started from anaerobic pond was about 29.18 ton/day, from facultative pond was about 4.36 ton/day and from maturation pond was about 3.42 ton/day. Greenhouse gas as CO2e emission from each stage on Set B started from anaerobic pond was about 229.01 ton/day, from facultative pond was about 8.98 ton/day and from maturation pond was about 11.15 ton/day. Emissions of Set B was much higher than Set A due to different sampling day causing different initial concentration of COD. Initial concentration of COD on Set B was higher than on Set A. Total emissions of greenhouse gas from wastewater treatment in WWTP Bojongsoang was about 279.46 ton/dayÂ Keywords: greenhouse gas; wastewater treatment plant, emission, CO2e, pondÂ ABSTRAKÂ Potensi emisi gas rumah kaca CH4 dan CO2 dari pengolahan air limbah domestik di IPAL Bojongsoang dipancarkan dari proses pengolahan air limbah di kolam anaerobik, kolam fakultatif dan kolam maturasi masing-masing pada Set A dan Set B. Faktor emisi CH4 dan CO2 didasarkan pada standar IPCC dan nilainya tergantung pada jenis perawatan. Gas rumah kaca sebagai emisi CO2e dari setiap tahapan pada Set A mulai dari kolam anaerobik sebesar 29,18 ton/hari, dari kolam fakultatif sebesar 4,36 ton/hari dan dari kolam maturasi sebesar 3,42 ton/hari. Gas rumah kaca sebagai emisi CO2e dari setiap tahapan pada Set B mulai dari kolam anaerobik sebesar 229,01 ton/hari, dari kolam fakultatif sebesar 8,98 ton/hari dan dari kolam maturasi sebesar 11,15 ton/hari. Emisi Set B jauh lebih tinggi dari Set A karena hari pengambilan sampel yang berbeda menyebabkan konsentrasi awal COD yang berbeda. Konsentrasi awal COD pada Set B lebih tinggi dari pada Set A. Total emisi gas rumah kaca dari pengolahan air limbah di IPAL Bojongsoang adalah sekitar 279,46 ton/hariÂ Kata kunci: gas rumah kaca; instalasi pengolahan air limbah, emisi, CO2e, kolam
Analisis Respon Siswa SMA di Kabupaten Situbondo terhadap Potensi Pemanfaatan Sampah Plastik sebagai Sumber Energi Listrik Rumahan
Authors: Damayanti Putri Sovi , Sudarti Sudarti
Published: October 2023

Plastic waste is one type of waste that is very difficult to decipher in the environment so as to reduce it and not pollute the environment many ways that have been done, such as 3R (Reduce, Reuse, Recycle) and currently many are utilizing it to become an alternative energy source. The purpose of writing this article is to find out the extent of the response of high school students in Situbondo district to the potential utilization of plastic waste as a source of home electrical energy according to the title of this article. The research method used is descriptive quantitative with data collection method using questionnaire method (questionnaire) through google form on high school students in Situbondo district. And the results from 87 high school students that plastic waste in Situbondo district is adequate to be used as a source of electrical energy and they are interested in learning it, but they are not sure if plastic waste as a source of small-scale electrical energy (home) can be applied in Situbondo in the future.Â Keywords: plastic waste, energy sources, home electricityÂ ABSTRAKÂ Sampah plastik merupakan salah satu jenis sampah yang sangat sulit diurai di lingkungan sehingga menguranginya dan tidak mencemari lingkungan banyak cara yang telah dilakukan, seperti 3R (Reduce, Reuse, Recycle) dan saat ini banyak yang memanfaatkannya menjadi sumber energi alternatif. Tujuan penulisan artikel ini adalah untuk mengetahui sejauh mana tanggapan siswa SMA di Kabupaten Situbondo terhadap potensi pemanfaatan sampah plastik sebagai sumber energi listrik rumah sesuai dengan judul artikel ini. Metode penelitian yang digunakan adalah deskriptif kuantitatif dengan metode pengumpulan data menggunakan metode kuesioner (angket) melalui google form kepada siswa SMA di Kabupaten Situbondo. Dan hasil dari 87 siswa SMA tersebut adalah sampah plastik di Kabupaten Situbondo cukup untuk digunakan sebagai sumber energi listrik dan mereka tertarik untuk mempelajarinya, tetapi mereka tidak yakin apakah sampah plastik sebagai sumber energi listrik skala kecil (rumah) dapat diterapkan di Situbondo di masa depan.Â Kata Kunci: sampah plastik, sumber energi, listrik rumahÂ
Writing cell memory: how Histones play a role in Epigenetic Memory
Authors: Flury Valentin , Groth Anja
Published: October 2023

Our cells remember their cell type-specific functions during their lifetime using modifications on histones, the proteins packaging DNA. Such epigenetic memory is challenged during DNA replication when histones are evicted from DNA. We reveal new evidence that cells recycle histones H2A-H2B to replicated DNA with their modifications, hereby providing epigenetic memory across cell division.
Artistic and stylistic features of the novel by Nikolai Mordinov - Amma Achchygyia "Springtime" ("Saasky kem")
Authors: Еfremova N. A.
Published: October 2023

The article provides a complete stylistic analysis of the text of the novel by the Yakut classic writer Nikolai Mordinova - Amma Achchygyia "Springtime" ("Saasky kem") and the artistic and stylistic features of the work were revealed. The epic novel "Springtime" is called the encyclopedia of the Yakut pre-revolutionary life. In it, the author authentically reflected the way of life, customs and culture of his people, convincingly showed the awakening during the formation of Soviet power in remote Yakutia. The work went through about 10 editions in Yakut, Russian, and is translated into Ukrainian, Hungarian and Czech. It is known that in the history of Yakut literature there are two editions of the novel: the first edition, published in 1944 without amendment, and the second, corrected and supplemented, which received wide recognition from readers and declared itself as a classic canon of the epic novel of the Soviet period. The language and style of the novel "Springtime" has its own unique, artistic and aesthetic features. It is noticeable that in the second edition the author worked diligently on the text of the work: the reader admires the artistic depiction and the richness of his native language. Especially in the first and third parts of the novel, stylistic figures of speech (actualization, anaphora, anaepiphora, antipophora, antithesis, homeology, gradation, concatenation, epiphora, etc.) are often found, generating verbal harmony and a special style of the writer. The speech of the characters, monologues and dialogues. are also conveyed in the literary-processed colloquial language of that time. It must be admitted that the language and style of Nikolai Mordinov - Amma Achchygyia is the canon of the Yakut literary language and serves as a vivid example for many writers of modern literature.
THE ANCIENT RUSSIAN UNFORTIFIED SETTLEMENT MALYE VSEGODICHI IN THE LOwER REACHES OF THE UVOD-RIVER: BASED ON THE MATERIALS OF THE PRESERVING EXCAVATIONS
Authors: Аверин В.А. , Аверина А.В. , Барышников В.Ю.
Published: October 2023

В статье рассматриваются результаты охранных раскопок древнерусского селища Малые Всегодичи. На основе анализа керамического комплекса, а также индивидуальных находок сделан вывод о том, что средневековое поселение возникло в XII – первой половине XIII в. В составе коллекции присутствуют предметы «городской материальной культуры». Пик развития поселения приходится на вторую половину XIII – XV в. Позднее жизнь на селище угасает. В ходе раскопок найдены также единичные предметы раннего железного века, эпохи бронзы и раннего неолита.

The article presents the results of the preserving excavations of the ancient Russian unfortified settlement Malye Vsegodichi. The medieval settlement dates back to the 12th – 1st half of the 13th centuries. Some of the artefacts in the collection refer to the urban material culture. Its development peak dates back to the 2nd half of the 13th – 15th centuries. Later life on the settlement fades. These conclusions are based on the analysis of the pottery as well as the individual findings. Particular findings belong to the early Iron Age, the Bronze Age or Early Neolithic.
THE INFLUENCE OF TRENDS IN THE DEVELOPMENT OF THE MARKET OF SNACK PRODUCTS ON THE FORMATION OF TOOLS FOR THE PROMOTION AND SALE OF DIETARY SNACKS AND ECO-PRODUCTS
Authors: ЖИЛЬЦОВА М.С. , КУЗНЕЦОВА О.А.
Published: October 2023

Рынок эко- и диетических продуктов в последнее десятилетие активно развивается. Маркетинговые ис- следования, проводимые различными компаниями, показывают, что в РФ большинство населения (59%) постоянно покупает различные виды снеков для перекусов, которые, по мнению респондентов, важны для работы их голов- ного мозга (76%), эмоционального состояния (74%) и здоровья в целом. Замена перекусов на полезные и экологич- ные продукты – важное направление для развития пищевых производств. Приведены результаты маркетингового исследования рынка экопродукции, снеков, определены основные потребительные предпочтения. Обозначена важ- ность маркетплейсов в продвижении диетической и экопродукции, предложены направления совершенствова- ния маркетинговой деятельности их производителей в целях завоевания новых целевых сегментов потребителей.

Themarketfordietaryandorganicproductshasbeenactivelydevelopinginthelastdecade.Marketingresearchconducted by various companiesshows that in the Russian Federation the majority of the population (59%) constantly buys various types of snacks for snacks, which, according torespondents, are important for their brain function (76%), emotional state (74%) and health in general. Replacing snacks with healthy andenvironmentally friendly products is an important direction for the development of food production. The results of marketing research of the market of eco-products, snacks are given, the main consumer preferences are determined. The importance of marketplaces in the promotion of dietary and organic products is indicated, directions for improving the marketing activities of their manufacturers in order to conquer new target consumer segments are proposed.
Addressing sub-optimal poses in non-equilibrium alchemical calculations
Authors: Karrenbrock Maurice , Rizzi Valerio , Procacci Piero , Gervasio Francesco Luigi
Published: October 2023

Alchemical transformations can be used to quantitatively estimate absolute binding free energies at reasonable computational cost. However, most of the approaches currently in use require knowledge of the correct (crystallographic) bond position. In this paper we present a combined Hamiltonian replica exchange non-equilibrium alchemical method that allows to reliably calculate absolute binding free energies, even when starting from sub-optimal initial binding poses. Performing a preliminary Hamiltonian replica exchange enhances the sampling of slow degrees of freedom of the ligand and the target allowing the system to populate the correct binding pose when starting from an approximate docking pose. We apply the method on 6 ligands of the first bromodomain of the BRD4 bromodomain containing protein. For each ligand, we start non-equilibrium alchemical transformations from both the crystallographic pose and the top-scoring docked pose that are often significantly different. We show that the method produces statistically equivalent binding free energies making it a useful tool for computational drug discovery pipelines.
FAME.AL: Site-of-metabolism prediction with active learning
Authors: Chen Ya , Seidel Thomas , Jacob Roxane Axel , Hirte Steffen , Mazzolari Angelica , Pedretti Alessandro , Vistoli Giulio , Langer Thierry , Miljković Filip , Kirchmair Johannes
Published: October 2023

The ability to determine and predict metabolically labile atom positions in a molecule (also called “sites of metabolism” or “SoMs”) is of high interest to the design and optimization of bioactive compounds such as drugs, agrochemicals, and cosmetics. In recent years, several in silico models for SoM prediction have become available, many of which include a machine-learning component. The bottleneck in the further development of these approaches is the coverage of distinct atom environments and rare and complex biotransformation events with high-quality experimental data. In this context, active learning strategies could yield higher data efficiency and, in addition, provide guidance to experimentalists on which atom environments to investigate next for maximum information gain. Here we report on the development and validation of FAME.AL, an active learning approach for site-of-metabolism prediction that builds on the previously published FAst MEtabolizer (FAME 3). The active learning approach yielded competitive performance for phase 1 and phase 2 metabolism (Matthews correlation coefficients of approximately 0.50 on holdout data) while using only 20% of the training data used by classical modeling setups. Besides high performance and high data efficiency, the active learning approach is also characterized by high robustness and speed. The approach is largely invariant to starting conditions and parameters, and substantial speed-ups can be yielded by using small atom batches rather than individual atoms during the iterative model-building process. The source code of FAME.AL is publicly available.
Transferable diversity – a data-driven representation of chemical space
Authors: Vuckovic Stefan , Gould Tim , Chang Bun , Dale Stephen
Published: October 2023

Transferability, especially in the context of model generalization, is a paradigm of all scientific disciplines. However, the rapid advancement of machine learned model development threatens this paradigm, as it can be difficult to understand how transferability is embedded (or missed) in complex models. While transferability in general chemistry machine learning should benefit from diverse training data, a rigorous understanding of transferability together with its interplay with chemical representation remains an open problem. We introduce a transferability framework and apply it to a controllable data-driven model for developing density functional approximations (DFAs), an indispensable tool in everyday chemistry research. We reveal that human intuition introduces chemical biases that can hamper the transferability of data-driven DFAs, and we identify strategies for their elimination. We then show that uncritical use of large training sets can actually hinder the transferability of DFAs, in contradiction to typical “more is more” expectations. Finally, our transferability framework yields transferable diversity, a cornerstone principle for data curation for developing general-purpose machine learning models in chemistry
Gestión del mesocurrículo por competencias en el programa de ingeniería química de la Universidad Pontificia Bolivariana
Authors: Arenas Castiblanco Erika , Forero Gaviria Luis Alejandro , Castrillón Hernández Fabio
Published: October 2023

La Universidad Pontificia Bolivariana (UPB) asume como currículo los conocimientos, experiencias y prácticas institucionalmente seleccionadas, organizadas y distribuidas en el tiempo para efectos de la formación. El punto de partida del diseño curricular es el Modelo Pedagógico Integrado de la UPB, el cual tiene un enfoque de formación por capacidades humanas y competencias con cinco principios curriculares: Contextualización, Interdisciplinariedad, integración, Interculturalidad y flexibilidad. En la UPB, el currículo es estructurado en tres niveles: la macro estructura asociada a los ciclos de formación, la meso estructura asociada a áreas o núcleos y la micro estructura asociada a los cursos. La macro estructura está definida para los programas de pregrado en cuatro ciclos: Básico de Formación Humanista, Disciplinar, Profesional y de Integración. La meso estructura está relacionada con propósitos formativos específicos y cada programa puede definir sus áreas o núcleos con base en estos propositivos formativos. Aunque las áreas o núcleos responden a problemáticas del contexto, tradicionalmente han sido definidas en términos de contenidos a partir de los cuales se agrupan una serie de cursos y no por competencias. En el caso del programa de Ingeniería Química de la UPB se había tenido áreas asociadas a Termodinámica, Operaciones unitarias, Diseño de procesos, Química entre otras. A raíz de la implementación del decreto 1330 del 2019 y la definición de resultados de aprendizaje, el programa de Ingeniería Química UPB ha adoptado como resultados de aprendizaje generales los 7 student outcomes que propone ABET. Estos resultados plantean el desarrollo de competencias en aspectos como diseño, trabajo en equipo, experimentación entre otros. Paralelamente se ha reestructurado la gestión meso curricular adaptando la gestión por áreas asociadas a cada uno de estos 7 resultados de aprendizaje generales. Esto ha llevado a que el currículo se gestione efectivamente en pro del desarrollo de competencias y los contenidos temáticos se conviertan en un medio para el logro de las competencias. Adicionalmente esta nueva forma de gestión del meso currículo permite fomentar más los cinco principios curriculares del Modelo Pedagógico de la institución dando respuesta al contexto donde estudios como la Encuesta de Talento Humano de la ANDI (2022) muestra que el país demanda profesionales con competencias más que con conocimientos específicos. Igualmente, se ha posibilitado que el trabajo entre los docentes sea más integrado a lo largo del plan de estudios, existiendo más interacción entre los docentes para establecer estrategias coordinadas para fomentar el desarrollo de las competencias y la identificación en forma más clara del rol de cada docente dentro del proceso o ruta de formación de la competencia.
Uso y apropiación de las tecnologías de la información de cara a las Industrias 4.0 en el sector turístico-hotelero en la ciudad de Medellín
Authors: Muñoz Sánchez Daniel Ricardo
Published: October 2023

El estudio aborda el problema de la falta de percepción y apropiación de la tecnología en las industrias culturales y creativas (ICC). Estas industrias a menudo subestiman o ignoran los beneficios que la tecnología puede aportar, debido a la percepción de su complejidad, costo o falta de necesidad. La falta de conocimiento y capacitación en tecnología ha llevado a algunas industrias a perder oportunidades de desarrollo. La pandemia de 2020 provocó una transformación digital en muchas empresas, incluyendo el sector turístico-hotelero. Esto plantea interrogantes sobre cómo se está utilizando y aprovechando esta nueva tecnología en dichas industrias. El estudio se centra en este sector, donde la gastronomía, el arte y la cultura desempeñan un papel importante, y busca analizar el grado de implementación y apropiación de la tecnología. La hipótesis planteada en el estudio sostiene que las ICC que han adoptado un modelo de Gestión de las Tecnologías de la Información (GTI) y han incorporado diversas tecnologías administrativas y experienciales son más competitivas y visibles en el mercado local e internacional, además de ofrecer una experiencia mejorada a los turistas. El objetivo es analizar el nivel de implementación y apropiación de la tecnología en el sector turístico-hotelero, en línea con la estrategia del sector. El estudio se basa en desarrollos previos, como la inauguración de un centro para la cuarta revolución industrial en Medellín en 2019 y la creación de un distrito creativo en 2020, que demuestran el potencial de combinar tecnología y cultura. Además, se hace referencia a investigaciones anteriores que resaltan la importancia de la tecnología en las ICC. Las implicaciones teóricas y prácticas de este estudio son significativas. Desde un punto de vista teórico, se busca proporcionar un marco conceptual de gobernabilidad de las tecnologías de la información (TI) adaptado a las ICC, así como recomendaciones para la correcta utilización de procesos tecnológicos. En términos prácticos, se pretende demostrar que la apropiación adecuada de la tecnología puede impulsar y generar nuevas y mejores experiencias para los visitantes y turistas. Además, se espera que el estudio ofrezca una base teórica para la conceptualización de modelos de GTI en las ICC.