bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of health education on lifestyle and health conditions of people with diabetes mellitus and/or hypertension treated in primary care
Authors: Pinheiro Ribeiro Adalberto , santos dias Xavier Matheus , ferreira freitas Ronilson
Published: April 2023

Introduction: Chronic Non-Communicable Diseases (NCDs) in particular Type II Diabetes Mellitus (DM) and Systemic Arterial Hypertension (SAH), are pathologies that are related to high rates of morbidity and mortality, mainly regarding their acute and chronic complications, Type II DM is characterized by an increased concentration of glucose in the bloodstream due to a deficiency in insulin secretion or action, and systemic arterial hypertension (SAH) is characterized by multifactorial clinical conditions of elevated and sustained levels of blood pressure above normal in the arteries. High drug costs, increased hospitalizations, increased numbers of doctor visits, lost productivity, and premature deaths are associated with patients with these NCDs. DM and hypertension are diseases that must be treated correctly in order to avoid complications and loss of quality of life. Objective: To evaluate the effects of health education on the lifestyle and health conditions of people with diabetes mellitus and/or hypertension treated in primary care. Methodology: This is a longitudinal epidemiological study, with a quantitative, exploratory nature. The population will be composed of users of Primary Health Care with diabetes and/or hypertension. The sample will consist of patients registered and monitored by the ESF health teams of a neighborhood of the city of Montes Claros - MG. As an instrument of data collection where will be used a questionnaire for socioeconomic evaluation, demographic and clinical aspects, food consumption, evaluation of physical activity level, evaluation of anthropometric measures and evaluation of self-care behavior. The students and the professor will invite health professionals to give the lectures. The research project will be submitted for review to the Ethics Committee on Research involving Human Beings of the Educational Association of Brazil - SOEBRAS, Montes Claros, where it will be subject to prior approval to conduct the study, according to Resolution 466/12.
Parvovirus B19 and blood transfusion
Authors: M Saleh Rania
Published: April 2023

Parvovirus B19 is a common human pathogen that is responsible for a wide range of clinical manifestations, including erythema infectiosum (fifth disease), arthropathy, and fetal hydrops. Infection with Parvovirus B19 can cause significant morbidity in certain patient populations, including pregnant women and individuals with underlying hematologic or immune disorders. This review highlights the importance of screening of Parvovirus B19 infection, particularly in high-risk populations.
Correct interpretation of carrier pigeon diseases - Collibacillosis
Authors: Zigo František , Ondrašovičov Silvia , Farkašová Zuzana
Published: April 2023

Despite the breeder’s efforts to minimize stress factors during the racing season, disease can occur even in the best lofts. Among the specific diseases caused by high performance, immunosuppression of the organism, imbalance of gastrointestinal micro flora of carrier pigeons and non-observance of hygienic conditions is included collibacillosis. Collibacillosis is localized or systemic infection caused entirely or partly by avian pathogenic Escherichia coli (APEC). Although some strains of APEC cannot cause disease by themselves, their pathogenic lifestyle, suggesting that infections might always be opportunistic or secondary to some most frequently predisposing diseases such as coccidiosis, adenovirosis, canker, intestinal worms and others. The disease causes reduction in performance or loss of infected pigeons, vomiting, diarrhoea, enteritis, dehydration, depressed feed intake or decreased growth rate in young pigeons. An outbreak of collibacillosis during the racing season is often the result of a combination of several factors that cannot be completely eliminated. It is therefore useful to develop a prophylactic plan in which the breeder focuses not only on the elimination of the main predisposing diseases, but also notices the factors that can stress the pigeons and thus cause an outbreak of APEC.
The biocreativity of intuitions, young planets with humans; imprinting, homosexuality, sexual abuse, stuttering and autism
Authors: Cuevas-Sosa Alejandro Cuevas-Sosa
Published: April 2023

The human body contains a second component that we call bioenergeme (BEG) and a third virtual or temporary component that we call biointerfaceme. For BEG research, the way in which it establishes bioenergemal (BEL; relating to BEG) communication with other BEGs (personal components of organized BEL energy) forms the main procedure that has enabled us to clarify that when the human or other organism body biocollapses (dies), the BEG detaches and passes from the biomaterial universe (BML; three-dimensional) in which we find ourselves to the BEL universe (possible fifth dimension), to which all BEGs of all biospecies arrive. For this, we assume that the BEG, together with the biointerfaceme, pass through the biointerfacemal universe (BIFL; fourth dimension) where the BEG detaches from it before entering the BEL universe. The set of universes BML, BIFL and BEL form what we call the unit universe (UU) [Ints 03/15/2023]. The BEL communication between BEGs and the bio-exchange of innumerable intuitions form a BEL set or bioset that, because it is so frequent, repetitive and forceful, acquires an undeniable and essential relevance. Ignoring this set, collective or intuitional network has been the rule in the history of terrestrial humanity, but now we are in a position to accept, study and know its implications, degree of influence and BEL participation in the UU. Trying to answer, among others, questions like: What properties does this intuitional set have? What BEL functions does it have? And, how does it participate in the multiple BEL interactions, innovations, transformations and creativity of the various BEL systems, ecosystems and environments of the UU?5-6 Through the Innovative BEL Instrument, and with the support of Linus Pauling and Stephen Hawking, we were able to substantiate that the history of sexual and gender abuse, in 100 women and 100 men, all of them completely homosexual, is more frequent than is supposed, leaving a permanent homosexual imprinting. Likewise, sexual abuse of babies can affect the natural learning of language, leaving the imprinting of stuttering and even altering social relationships and the physical-emotional development that the boy or girl would have to present, causing the imprinting of autism. The BEG is also damaged, leaving at least the three anomalous imprintings described [Ints 03/19/2023].
Ayurvedic management of immune thrombocytopenic purpura - a case report
Authors: Gupta Kshama , Mamidi Prasad
Published: April 2023

Immune thrombocytopenic purpura (ITP) is a bleeding disorder characterized by isolated thrombocytopenia. The course is more chronic in adults associated with higher mortality in older patients. In extreme cases of ITP, serious complications such as bleeding into the lungs, brain, or other vital organs can occur. Clinical manifestations include purpura, petechiae and ecchymosis. Majority of ITP patients are not getting reliable and durable remissions with modern medicine. The present case report deals with an elderly patient having chronic ITP with multiple comorbidities (obesity, schizophrenia, UTI and T2DM) approached for Ayurvedic treatment. Patient came with ecchymotic patches on both upper extremities with extremely low platelet counts (9700/mcL) was diagnosed as Tiryaggata Raktapitta and Ayurvedic treatment has been provided. Ayurvedic formulations (Putapakwa Vishama Jwarantaka Loha, Raktastambhaka Vati, Samshamani Vati etc) have improved the platelet counts (from the lowest count of 9700/mcL to highest count of 50000/mcL), hematological indices and quality of life in present case. Ecchymotic patches were completely disappeared without any further recurrences. The present case of ITP (Raktapitta) is a good example for Nidaanaarthakara Roga as it has manifested due to the consequences of malarial fever (Vishama Jwara). Ayurvedic treatment seems to be promising in the management of chronic ITP and generates hope for those patients who are having extreme thrombocytopenia, multiple comorbidities, reluctant (or unfit) for corticosteroids and invasive diagnostic procedures like bone marrow biopsy, and not satisfied with the available therapy from other systems of medicine. Further clinical trials with large sample size are required to substantiate the present case study findings.
Nutritional status of children and its association with parental smoking in Uttar Pradesh
Authors: Uzair Mohd Al , Ansar Sharmin , Kavish Mohd Salman , Ghani Akbar , Kumar Jaiswal Ajit
Published: April 2023

Background: Exposure to passive smoke due to smoking affects foetus and children. Previous studies have linked this exposure to an increased risk of malnutrition, infant death, respiratory illness and other disorders among infants. The investigation was made to explore the association between stunting of growth and children under 5 years of age who are underweight and are exposed to parental smoking. Exposure to second hand or passive smoke, has adverse impact during pregnancy on the mother as well as the baby. This could include cases of premature birth, birth defects or infant death and respiratory problems among the children. This study discusses the current evidence regarding the effects of parental smoking on their children's health in Uttar Pradesh. Methods: Parental smoking, and child anthropometry (undernutrition) were examined in a stratified, two-stage cluster sample of 232,920 kids under the age of 5 from National Family Health Survey (2015-16), out of which 35,766 were selected in the study from Uttar Pradesh. Prominent outcomes were that of stunting of growth and a proclivity in children towards remaining underweight. Results: Prevalence of parental smoking was found in 38.28% of households in Uttar Pradesh. Using the new World Health Organization child growth standards, prevalence of stunted growth, and underweight children was found in 39.34%, 31.15% of the households respectively. After adjusting for potential confounders parental (couple) smoking was associated with increased risk of stunting (AOR 1.17, 95%CI 1.0-1.37, p<0.05), and underweight children (AOR 1.09, 95%CI 0.93-1.28). Conclusion: In Uttar Pradesh, parental smoking is associated with birth factors nutritional status and may divert household funds from food and other necessities towards smoking habits. Parental smoking was also associated with increased risk of stunting of growth and underweight children in the children. The result also suggests that strategies to prevent passive smoke exposure in young children to minimize tobacco smoke exposure are an urgent public and child health priority
Method for calculation indicators steganographic systems in multiservice communication networks
Authors: Ibrahimov Bayram
Published: April 2023

An analysis of the performance indicators multiservice telecommunication networks using the sixth technological order based on the NGN (Next Generation Network) architectural concept and future FN (Future Networks) networks was carried out to build high-performance steganographic systems with increased covert channels throughput, ensuring the achievement of a certain level information security. Comprehensive criteria for the efficiency the functioning steganographic systems are considered and the channel capacity of the steganosystem as a communication system with packet switching is selected. On the basis of the study, a new approach to constructing a method for evaluating complex indicators of the quality of steganographic communication during embedding and extracting hidden data is proposed. The quality of steganographic communication refers to the properties stegano communication to ensure the efficiency of the system, both timely and reliable transmission of messages. On the basis of the proposed approach, the effectiveness steganographic systems in the construction of covert channels for the transmission secret data transmitted over communication channels was studied. Taking into account the new entropy approach, a method for calculating the indicators of the latent throughput steganographic systems in packet-switched communication networks has been created. As a result of the study calculation method, important analytical expressions were obtained for evaluating complex indicators throughput steganographic systems, such as the throughput of covert channels, the maximum possible value of the performance of a binary source packets, the average packet transmission time with the proposed coding scheme, and the residual throughput of the communication channel.
Pyrroloquinoline Quinone (PQQ): a novel approach to managing chronic inflammatory response syndrome and mitochondrial dysfunction
Authors: Jones Cameron L
Published: April 2023

Chronic Inflammatory Response Syndrome (CIRS) is a complex, multi-system condition associated with persistent inflammation in response to biotoxins like mould or other environmental triggers. Mitochondrial dysfunction has been implicated in the pathophysiology of CIRS, contributing to chronic inflammation and exacerbating symptoms. Pyrroloquinoline quinone (PQQ), a redox cofactor, has gained attention for its potential neuroprotective, anti-inflammatory, and mitochondria-supporting properties. Additionally, CIRS shares overlapping features with cytokine storm effects observed in COVID infection, long COVID, and potential inflammatory reactions related to mRNA vaccine administration. This letter explores the role of PQQ in managing CIRS and addressing mitochondrial dysfunction caused by multiple potential triggers. However, further research is needed to confirm the effectiveness and safety of PQQ in addressing CIRS and related conditions.
Fermented food products for gastrointestinal health and related diseases
Authors: Meena Sunil , Reddy B Keerthi , Chandra Rai Dinesh
Published: April 2023

The incidence of lifestyle diseases such as inflammatory bowel diseases is increasing due to unhealthy eating habits and modern lifestyles, resulting in a growing demand for fermented foods worldwide due to their scientifically proven functional and nutritional attributes. Fermented foods are obtained by controlled microbial growth and enzymatic degradation of food constituents. These foods have a good amount of probiotic bacteria and bioactive peptides that benefit human health. Bioactive peptides are formed by either fermentation or enzymatic hydrolysis of food proteins. Fermented foods and beverages i.e., dahi, yogurt, kefir, kimchi, sourdough bread, pickles play a significant role in gut microbiota balance and mental health. Starter culture used in the fermentation of food products provide various health-promoting activities to fermented foods like anti-oxidant activity, anti-hypertensive activity, probiotic activity and improves protein digestibility. Several groups of lactic acid bacteria (LAB) strains produce Exopolysaccharides (EPS) such as  and - glucans, galactans, fructans, and gluco- and fructo-oligosaccharides. EPS produced by LAB has a positive impact on gut health. In addition, probiotic bacteria have proven to be a beneficial ingredient for any gut disorder (inside or outside the GI tract). They regulate the level of immunoglobulins (IgA) and inflammatory cytokines and improve gut barrier activity. Symbiotic yogurt (made with bacterial strains of Lactobacillus acidophilus and Bifidobacterium longum) helps raise high-density lipoprotein (HDL) cholesterol and also changes the ratio of low-density lipoprotein (LDL) to HDL. Consumption of kefir inhibits the pathogen's action by the production of acids and bacteriocins. Isolation and pharmaceutical applications of health-promoting bioactive peptides from fermented foods have been emerging in dairy and food research areas.
Emerging coronavirus and characteristics: A minireview
Authors: Khan Sahrish , Bibi Abida
Published: April 2023

The emerging viral infections are a continuous threat to the modern world, like SARS CoV-2, a new viral pandemic which has taken number of lives. The initial outbreak was noticed in Wuhan city of China in late of December 2019, along with increasing number of cases in other places in the same city. The spread pattern of this virus changed from zoonotic transmission to human in an exponential way. As, there is no drug or vaccine available against this virus hence preventive measures are adopted only. Assessment of risks and biosafety training are important factors in the latter situation. Here is a brief insight about this novel corona virus strain including its virology, epidemiology, methods to diagnosis, clinical features and controlling measures for preventing spread of Covid-19.
Automation of the RT-PCR to detect SARS-CoV-2 approved in Mexico by using the BD Max open system
Authors: Vargas Eduardo Becerril , Etzael Antonio-Juárez , José Arturo Martínez-Orozco , Ángel Sánchez-Tinajero , Andrea Iraís Delgado-Cueva , Javier Prieto-Padilla , Lina Larios-Mondragón , Víctor Manuel Rodríguez- Sánchez , Daniel Valencia-Trujillo , María del Carmen García-Colín , Mario Mujica-Sánchez
Published: April 2023

The exponential increase in the number of cases of COVID-19 and the technical difficulties to obtain an RT-PCR result for SARS-CoV-2, according to Berlin protocol, enabled the migration of the manual PCR assay, validated by Instituto de Diagnóstico y Referencia Epidemiológicos (InDRE), to the BD Max system utilizing the use of reagents from BD Max open system. A total of 48 clinical samples were taken from patients who went to the emergency room with COVID clinical features; 46 % (22/48) were positive for SARS-CoV-2. The sensitivity of the automated BD MAX assay was 92% (20/22), compared with the manual PCR. The mean Ct was lower (27,1±5,5) with the automatized method for the RdRp gene, compared with the manual procedure (27,9±6,1), there was no significant difference (p=0.39). The use of the BD MAX open system allows SARS COV detection because it has a high performance and diminishes the time to obtain the results.
The epidemiology of Coronavirus SARS Cov-2 virus in Iran
Authors: Jamali Houshang , Reza Jafari Mohamad
Published: April 2023

Background and objectives: SARS Cov-2 the enveloped, non-segmented, positive sense RNA virus has changed the biological life of the planet Earth in a short time. Since COVID-19 is now considered a pandemic disease and COVID-19 is now spread in all regions of this country, the goal of present study was to observe the spread of the disease in Iran and the problems in treating the disease. Methods: First, the virus and its history was reviewd, and then the epidemic of this disease from the initial stages to present time (1/18/98) was examined and the problems were expressed, then solutions were proposed. Conclusion: In order to protect the people and their resources (the same people and equipment), the chain of infection should be cut off and the rate of infection should be reduced so that the treatment system can respond to patients. A method to prevent the spread of SARS Cov-2 is to quarantine cities and areas infected with the virus. Quarantine should be started before the initiation of symptoms.
Could HPV be implicated in oral and oropharyngeal carcinoma in Bahia, Brazil?
Authors: Rocha Gadelha Sandra , Pinto dos Santos Francine , Barbosa Costa Galileu , Ribeiro dos Santos Uener , Magalhães Bronze Kariton , Leal Macedo Cláudia , Juliano Marin Lauro
Published: April 2023

Tobacco use and alcohol consumption are the principal risk factors implicated in head and neck cancers, however, the presence of HPV has also been associated. Here, we sought to correlate risk factors such as socio-demographic and behavioral variables, and the presence of HPV, to head and neck cancer occurrence. During August 2016 – December 2017, paraffin embedded samples from two anatomic pathology services of two populous cities in the state of Bahia were analyzed. To detect the presence of HPV, the formalin-fixed, paraffin embedded tissue samples were initially deparaffinized for subsequent DNA extraction. Nested-PCR was applied to detect HPV DNA, and viral subtyping was confirmed through specific PCR primer and sequencing. Most of the patients confirmed being smokers and drinkers. HPV was detected only in 7% of the samples, a histopathological diagnosed benign lesion of laryngeal papilloma (HPV 11), and a malignant lesion of the hard palate (HPV type not specified). Our findings indicated that tobacco use and alcohol consumption were correlated as the highest risk factors for the development of neoplasms. Although HPV prevalence was low, we could not neglect HPV involvement in head and neck cancers in individuals from Bahia State. Furthermore, HPV+ cancers respond better to therapy, therefore, defining the type of tumor is important to determine the most effective treatment.
Recovery of COVID-19 in a patient with recent diagnosis of HIV infection
Authors: R Delgado Sandra
Published: April 2023

As of May 28, 2020, 5 765 094 cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been reported in 188 countries on five continents. Between March 6, 2020, and May 25, 2020, in Peru, a total of 129 751 confirmed cases have been registered. Since the first reports from Wuhan in China in December, 2019, Coronavirus disease 2019 (COVID-19) was described in only one patient with HIV in Wuhan, China. Only a few reports or case series have been published regarding the course of SARS-CoV-2 in patients with HIV.
Mode of infection and some diseases caused by Epstein Barr virus: The most ubiquitous, common malignant and characteristic virus
Authors: M Bastawecy Iman
Published: April 2023

Epstein Barr virus (EBV) was detected for the first time by electron microscopy (EM) in a malignant Burkitt’s lymphoma. EBV has a worldwide distribution and its prevalence is more than 90%. It is a malignant virus, symptoms vary from mild or find no symptoms in some individuals and serious symptoms or cancers in others. EBV is a characteristic one since it has a lot of properties to become latent and modulate the host immune system in a serious manner in some conditions where it has many proteins having sequence and functional homology with many human proteins. EBV could be transmitted through saliva or contact with the air borne, blood transfusion, organ transplantation semen or cervical secretions. EBV Causes a lot of diseases which varies according to some factors. Rediagnosis For COVID-19 is recommended by considering it EBV or ovine herpes virus 2 (OvHV-2) where I think that they are the same virus With two names according to human or veterinary medicine because accurate diagnosis is the first and most important step for controlling COVID-19 and I show that the obtained RNA and considered as corona Virus is mainly one of the messenger RNA (s) of EBV (0vHV-2) to be translated for proteins demanded by this herpesvirus. This false diagnosis may be performed with other RNA viruses named previously. Proper diagnosis will be achieved by electron microscopy for detection of herpes viral particles and sequencing of glycoprotein B complete gene. Another recommendation is taking in consideration that stool is among routes of infection as well as milk and colostrum with special care during management for all animals or birds ( because all species are susceptible ) which also give good chance for experimental application of vaccines, antibodies as well as studying pathogenesis and pathology of the virus.
Comparison of food ingredients of Oysters mushroom cultivation on agricultural waste
Authors: Shahsavani  Lida
Published: April 2023

The cultivation of edible mushroom on agricultural and industrial waste can be considered as one of the most effective solutions. The use of waste as a substrate for mushroom not only increases its nutritional value and contributes to food security in the community, but also reduces environmental pollution. In this study, Sweet fruit pleurotus Floridain Florida was cultivated on two types of agricultural waste (rice straw and wheat straw) and then the amount of yield, fat, ash, sodium, potassium, calcium, zinc and iron was evaluated. Statistical studies indicated that cultivation mushroom on the wheat straw was more suitable for fruiting and nutritional value.
Effect of the obese phenotype on brain composition in congenic lean and obese LA/Ntul//-cp rats
Authors: Tulp Orien L
Published: April 2023

To determine if the obese phenotype impacted on brain development and composition, groups of congenic male lean and obese littermates of the LA/Ntul//-cp rat strain were fed on a standardized nutritionally adequate diet in littermate pairs from weaning until adulthood. The obese phenotype of his strain develops early onset chronic hyperinsulinemia associated with hypertrophic-hyperplastic obesity during early postweaning growth. At 10.5 months of age, animals were sacrificed by cervical dislocation, and brain tissues excised in its entirety, weighed to the nearest mg, and measures of protein, DNA and lipid determined. Body weights (BW) of obese were significantly greater than lean. Brain mass (BrM) of lean > obese, and BrM:BW of lean was greater obese. Brain protein content (BPC) and Brain DNA (BDNA) of lean was greater than obese. Brain lipid as a percent was similar in both phenotypes and net brain lipid content was proportional to brain mass. Total body fat mass of obese was significantly greater than occurred in lean littermates. Inflammatory cytokines residing in adipose tissue have been reported to contribute to DNA damage in neuronal and other tissues, impede cell replication, and accelerate cell senescence. These results indicate that brain growth and cellular development is impaired in the hyperinsulinemia-prone obese phenotype of this strain, and are likely associated with development of a chronic inflammatory syndrome and cytokine expression common to excessive fat accretion and obesity
Unload control - efficiency strategy and rainfall control in urban wastewater systems
Authors: Alves José M Correia
Published: April 2023

Controlling the influx of rainwater to domestic wastewater transport and treatment systems, aims to reduce its economic impact on energy and the interference in the treatment process, taking into account the technical and legal issues associated with its upstream rejection of such infrastructure. In order to guarantee safety in the flow thinning, we will have to monitor the quality of the effluent, basically in terms of COD, which directly indicates the degree of dilution and consequent influx of rainwater, and the flow rates upstream and to be discharged. This pilot project intends to implement the digitization of the process with automatic monitoring and control equipment with information sent to SCADA and availability of information to the Portuguese Environment Agency.
Role of nutrition in wound closure: a case report
Authors: Gonzalez Dania Ramírez , Jorge Alberto García Martinez , Valeria Karina Ramirez Lopez , Armando Francisco González González
Published: April 2023

Malnutrition is a common risk factor in chronic wounds due to its long healing period and it should be considered in their prevention. Nutrition during the wound-healing process should be adequate for the increased demand. The objective from this study is to present a case report of the evolution of a chronic infected wound after multidisciplinary management, including surgical approach, antibiotic therapy, and nutrition for its resolution. A 43-year-old female who begins with sudden pain in the left inguinal region associated with swelling. She received analgesic treatment without improvement and decided to attend the hospital where is diagnosed with septic shock secondary to soft tissue infection. Surgical drainage was done and a vulvar abscess was found, dissecting from the mount pubis to the ischiopubic fossa with necrotic tissue and fetid purulent material. In the postoperative period, multiple surgical lavages and debridements were carried out, followed by a VAC system. Nutritional parameters were below the acceptable level, parenteral nutrition was started and enteral nutrition with arginine boluses. Admission to the nutritional support service with parenteral nutrition and subsequently switching to enteral nutrition with arginine support raised their levels according to the improvement of the wound previously reported. Nutrient deficiency has been found in patients with chronic wounds and although the role of nutrition has not been adequately established, clinical improvement can be attributed to the establishment of treatment with complementary nutrition. Due to the good clinical response of our patient, we suggest formulas supplemented with arginine as part of the complete treatment (medical and surgical). The use of arginine dietary supplements in surgical patients leads to a consistent and significant reduction in postoperative infections.
The role of the territory organization process in the sustainable use of functioning resources
Authors: Ciugureanu Ludmila , Botnarenco Ion
Published: April 2023

The measures, which protect land resources, including agricultural land whose main object is soil, is a highly imported problem worldwide. In un committees and meetings, a topic of discussion is the issue of sustainable use and protection of land resources. Agrarian policy in the EU is also oriented towards the sustainable use of natural resources, the protection of land resources, soil resources, etc. The Agrarian policy in the Republic of Moldova is the sustainable use and protection of limited land resources. Since 1992, with the implementation of the land reform (transmission of agricultural land to private ownership), an important process in the field of territory organization has been neglected, namely the sustainable use of agricultural land, as well as the application of measures for the organization of the territory.
Residential exposure to non-ionizing electromagnetic radiation from mobile base stations: a systematic review on biological effects assessment
Authors: B Samaila , AH Abdullahi , MN Yahaya , N Abubakar
Published: April 2023

The effects of non-ionizing electromagnetic radiation from cellular base station exposure on human health are discussed in this review. Because of technological development, electromagnetic emissions are present at high levels in human existence. Due to the health risks linked with exposure to electromagnetic radiation (EMR), its effects are known. The systematic review work was done to identify measured values of non-ionizing radiation (such as power density and electric and magnetic fields) emitted by phones and GSM base stations, along with any potential biological consequences connected with the measured values. In the literature, all measurements of power density, electric fields, and magnetic fields were made using various instruments over a variety of base station distances and times. The findings from the literature showed that the non-ionizing electromagnetic radiation's power density, electric field, and magnetic field varied with distance from the tower and were highest at the closest distances. The findings also demonstrate that, in some situations, home exposure levels to base station-emitted non-ionizing electromagnetic radiation are within the limit. In some instances, however, the situation varies, and persons living close to base stations experience health effects from high levels of non-ionizing electromagnetic field exposure. The biological effects of non-ionizing electromagnetic radiation exposure in homes are summarized in this article. Numerous studies to date have established the dangers of mobile phone base station radiation to people and wildlife. The negative biological effects of exposure to non-ionizing electromagnetic radiation were compiled from numerous articles. Residents who are exposed to higher levels of non-ionizing electromagnetic radiation at home are more likely to experience symptoms like fatigue, nausea, disturbed sleep, discomfort, headache, memory loss, skin problems, visual disturbances, hearing problems, dizziness, muscle pain, DNA damage, and infertility. Some mobile base stations are situated quite close to homes and commercial buildings, putting individuals at risk from the base stations' electromagnetic radiation. Depending on the infrastructure impediment, such as interior obstructions or buildings, the emf changed from location to location. As a result, cellular mobile towers shouldn't be placed closer than 200 meters from residential structures.
Primary sclerosing cholangitis revealed by pregnancy
Authors: Conte Alpha Boubacar , Coulibaly Fatoumata , Jayi Sofia , Fdili Alaoui Fatima Zohra , Chaara Hikmat , Melhouf Moulay Abdelilah
Published: April 2023

Introduction: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of poorly understood, probably dysimmune, mechanism. It is a slow-growing disease, with a tendency to worsen. We are reporting a rare case of primary sclerosing cholangitis revealed during pregnancy. Case presentation: A 30-year-old woman who had pruritus during 12 weeks of gestation with a disturbance of the liver biologic tests. Imaging investigations found a chronic liver with areas of stenosis and dilation of VBIH and right and left hepatic bile ducts suggestive of primary sclerosing cholangitis with evidence of portal hypertension. She was put under treatment by ursodeoxycholic acid and the pregnancy proceeded without maternal-fetal complications giving birth to a healthy newborn with uneventful postpartum follow-up. Conclusion: This case highlights the importance of considering pathologies other than benign intrahepatic cholestasis of pregnancy as the cause of cholestasis during pregnancy.
Effects of uterine polyps on embryo implantation in IVF cycles
Authors: Javed Murid , Alfhead Noura K , Shaheen Sameera , Yahya Khaleel Al
Published: April 2023

Embryo implantation requires healthy uterine endometrium for natural or assisted reproductive technology conception. However, in presence of any endometrial anatomical abnormality or disease, implantation is affected. Uterine or endometrial polyps are over growths of endometrial cells that extend into the uterine cavity. They are usually noncancerous. There can be one or many polyps. They range in size from a few millimeters to several centimeters or larger. They may cause vaginal bleeding in between periods, heavy periods, frequent or unpredictable periods and infertility. The objective of this study was to find out effects of endometrial polyps on embryo implantation in assisted reproductive technology cycles of Saudi women being treated at an infertility clinic. This was a case-control study. The participants were in ratio of 5:1 i.e., for every 5 patients there was one control. The polyp diagnosis was carried out with ultrasound and endometrial biopsy. We observed high incidence of implantation failure in patients with uterine polyps as compared to that in the control patients. The results of this study indicated that the presence of endometrial polyps is a risk factor for infertility and failure of conception after in vitro fertilization.
Positive margins in cervical H-SIL conization: Can we predict them?
Authors: Tomas García Balcarce , A Folino , F Quiroga , C Chadi , A Boixart , T Ramilo , Graffigna A Camargo , F Bianchi
Published: April 2023

Background: Cervical cancer is the second most common gynecological cancer in the female population. Cervical cancer screening includes cytology and tests for oncogenic subtypes of human papillomavirus (HPV), impacting on a significant decrease in mortality. In patients with a diagnosis of high-grade squamous intraepithelial lesion (HG SIL), the recommended management is excisional treatment (ET). The higher rate of persistent disease is associated with a positive margin status, larger lesion size, endocervical involvement and HPV positive test six months after treatment, especially HPV 16 subtype. Objective: To identify clinical and/or pathological features capable of predicting the compromise of the margins in the excisional treatment specimens. Methods: It is an observational, retrospective study carried out in Sanatorio Güemes between September 2017 and June 2020. All those patients with HG SIL who underwent excisional treatment were analyzed. The variables considered were the pre-treatment status of the endocervical canal, the size of the specimen (height), the type of transformation zone, the presence of greater pathology in the definitive specimen, the delay in consultation and the smoking habit. The relative risk of presenting compromised margins for each of the variables was analyzed. Findings: Our study shows 124 patients who received excisional treatment for HG SIL, 32 had compromised endocervical margins of the resection specimen. The delay in consultation between the biopsy and the ET has a significant impact on the state of the margins (RR 2,26; IC95 1,27-4; p 0,009). The presence of greater pathology (microinvasive carcinoma or higher stage) in the group with compromised margins (34,4% vs. 5,4%) highlights the importance of a comprehensive pre-treatment advisement to the patient concerning the diagnostic role of the ET in our population.
VSRR 028: Births: Provisional Data for 2022
Authors: Hamilton Brady , Martin Joyce , Osterman Michelle
Published: April 2023

This report presents provisional 2022 data on U.S. births. Births are shown by age and race and Hispanic origin of mother. Data on cesarean delivery and preterm births are also presented.
Choice of specific and anticoagulant therapy in patients with newly diagnosed chronic thromboembolic pulmonary hypertension, depending on operability status
Authors: Valieva Z. S. , Martynyuk T. V.
Published: April 2023

Aim. To study the features of anticoagulant and specific therapy in newly diagnosed patients with chronic thromboembolic pulmonary hypertension (CTEPH) depending on operability status.

Material and methods. The study included 319 patients with CTEPH, hospitalized for the first time in the E.I. Chazov National Medical Research Center of Cardiology for the period from 2012 to 2021. The diagnosis was established according to current guidelines. Depending on operability status, which was assessed by a multidisciplinary team, two following groups were formed: patients with inoperable CTEPH (n=222) and patients with operable CTEPH who underwent pulmonary thromboendarterectomy (n=97) (time from diagnosis to surgery, 13,3 [6,3; 27,1] months). Demographic, functional status, anticoagulant therapy and specific therapy regimens were analyzed.

Results. At the time of initial admission to the expert center, 80,56% of patients received anticoagulant therapy, most often warfarin in both inoperable (38,74%) and operable patients with CTEPH (55,67%), respectively, and rivaroxaban (25,68% and 20,62%, respectively); 6,27% took only antiplatelet agents, and 13,17% did not receive anticoagulant therapy. In the hospital, inoperable patients were most often prescribed low molecular weight heparins in therapeutic doses (47,3%), warfarin — 38,7%, and to a lesser extent (12,16%) — direct oral anticoagulants (DOACs). Operable patients were more often prescribed warfarin (54,64%), while low molecular weight heparins — in 37,1%, and individual patients were prescribed (8,25%) DOACs.

Specific therapy at the admission time was received by 19,59% of operable and 23,42% of inoperable patients with CTEPH, mainly in the sildenafil monotherapy regimen. After verification of the diagnosis, the majority of patients (64,4% of inoperable and 46,4% of operable patients with CTEPH) received monotherapy with sildenafil (72,82%) and riociguat (46,75%). The addition of a second drug, mainly within the initial combination therapy, was required in 5,15% of operable patients and 10,81% of inoperable patients, while 1,06% and 0,9% of operable and inoperable patients with CTEPH, respectively, received triple specific therapy.

Conclusion. For the first time in Russian practice, anticoagulant and specific therapy were studied in newly diagnosed patients with CTEPH, depending on the operability status.
Clinical and prognostic role of sleep-related breathing disorders in patients with heart failure depending on body mass index
Authors: Medvedeva E. A. , Korostovtseva L. S. , Bochkarev M. V. , Sazonova Yu. V. , Sviryaev Yu. V.
Published: April 2023

Aim. To determine the clinical features of sleep-related breathing disorders (SRBDs) and their prognostic role in patients with heart failure with reduced ejection fraction (HFrEF) depending on the body mass index (BMI).

Material and methods. This prospective cohort study included 111 patients with HFrEF who were hospitalized with symptoms of decompensated heart failure. All patients underwent a standard examination and polysomnography after HF compensation. Patients with HF were divided into 3 groups depending on the body mass index: group 1 — BMI of 18,5-25 kg/m2, group 2 — BMI 25-30 kg/m2, group 3 — BMI ≥30 kg/m2. Primary endpoint was all-cause mortality. The median follow-up was 918 (163; 2495) days. Information was collected twice a year through telephone contacts.

Results. In the 1st group, SRBDs occurred in 74% of cases, while in overweight and obese patients — in 84% and 86% of patients, respectively. In multiple comparisons of the three groups, the hypopnea index and apnea/hypopnea index (AHI) in the REM sleep were significantly different (p<0,05), when pairwise comparison revealed significant differences only between groups 1 and 3. Hypoxemia, estimated by average saturation ((95 (94,1-95,75), 96 (95,5-96,3), and 92,05 (91,6-92,5), p=0,0001) and average desaturation (5,9 (5,2-7,25), 4,1 (3,8-8,8), and 10 (8,6-11,4), p=0,002), was more pronounced in groups with obesity. In groups 1 and 2, negative correlations were observed between average oxygen saturation and BMI (r=-0,398, p=0,012 and r=-0,635, p=0,0001), which was not observed in patients with obesity. Survival analysis showed a worse prognosis in patients with normal BMI with and without moderate sleep apnea, while obese patients without moderate sleep apnea had a better prognosis than overweight patients (log-rank=5,989, p=0,05).

Conclusion. In patients with HFrEF, obesity is associated with a higher incidence of severe apnea, more severe hypoxemia, which does not correlate with BMI. The worst prognosis was observed in patients with normal BMI, while the most favorable prognosis — in obese patients without moderate sleep apnea.
Evidence-based perspective on heart failure and osteoporosis: a systematic review
Authors: Larina V. N. , Shcherbina E. S. , Dryutova V. V. , Larin V. G.
Published: April 2023

Aim. To study the prognostic relationship between heart failure (HF) and osteoporosis, as well to search for modern principles and approaches to the management of patients.

Material and methods. A search was conducted in the PubMed, RSCI databases from 2012 to 2022 using keywords. The studies were selected according to the PRISMA algorithm.

Results. Based on the results, 124 papers were received, and 9 articles were eventually selected. The age of the patients was at least 49 years (mainly elderly patients). The median follow-up ranged from 12 months to 10,5 years. The larger percentage were females.

Conclusion. Osteoporosis was associated with the HF risk, and patients with heart failure had a higher risk of accidental fracture due to accelerated bone turnover. The foregoing makes it possible to consider patients with HF as a group of increased risk of osteoporosis and associated fractures, and impaired mineral metabolism as a possible additional cardiovascular risk factor.
Twenty-four-year-old patient with heart failure after myocarditis. Results of quadruple therapy: a case report
Authors: Larina V. N. , Skiba I. K. , Romanova T. A. , Skiba A. S.
Published: April 2023

Introduction. The data of epidemiological studies indicate maintaining high prevalence of heart failure (HF) and an unfavorable prognosis for such patients, which creates the need to change the treatment approach. A feature of the case presented is the young age of the patient and a significant effect that was achieved with quadruple therapy for HF with reduced ejection fraction (EF) after myocarditis.

Short description. A three-year follow-up of a patient with HFrEF was carried out. In 2019, at the age of 21, the patient had acute myocarditis, diagnosed according to magnetic resonance imaging. The outcome was postmyocarditis cardiosclerosis, complicated by HFrEF. She had two episodes of HF decompensation, followed by hospitalizations in a cardiology hospital. During the treatment, a quadruple therapy was initiated (angiotensin receptor-neprilysin inhibitor, beta-blocker, mineralocorticoid receptor antagonist, sodium-glucose cotransporter 2 inhibitor), against which a significant improve was noted in the form of decrease in congestion symptoms, natriuretic peptide level from 1956 to 501,4 pg/ml, an increase in LVEF from 33% to 39%. The patient is currently on the waiting list for a donor heart transplant.

Conclusion. The case report focuses on the complexity of not only the timely diagnosis of myocarditis, but also the treatment of its consequences. The appointment of quadruple therapy for a patient with HF after myocarditis has improved the patient’s clinical condition before heart transplantation. However, this approach needs to be confirmed in a larger number of patients.
Acute decompensated heart failure in patients with prediabetes: relationship with risk factors and comorbidities
Authors: Koziolova N. A. , Mironova S. V. , Ulybina E. V.
Published: April 2023

Aim. To determine the incidence, risk factors and course of acute decompensated heart failure (ADHF) in patients with prediabetes.

Material and methods. Within 24 months, 426 patients hospitalized to cardiology department of a multidisciplinary hospital with ADHF were consecutively included in the study. In addition, 136 patients who met the inclusion criteria and did not have exclusion criteria were divided into 2 groups depending on prediabetes presence. The first group consisted of 51 (37,5%) patients with prediabetes, the second — 85 (62,5%) patients without this pathology. ADHF was verified based on a rapid increase in symptoms and signs of hypoperfusion. Prediabetes was defined according to World Health Organization criteria. The risk level for type 2 diabetes was determined using the FINDRISC online calculator. In the first 48 hours of hospitalization, echocardiography was performed. The serum concentration of N-terminal pro-brain natriuretic peptide (NT-proBNP) and cystatin C was determined using enzyme immunoassay.

Results. The incidence of prediabetes among patients with ADHF was 37,5%. In 9,8%, prediabetes was verified prior to hospitalization. Patients with prediabetes and ADHF were younger and were more likely to have obesity with a body mass index (BMI) of more than 30 kg/m2, non-alcoholic fatty liver disease, and higher waist circumference. In patients with ADHF and prediabetes, congestion symptoms were more pronounced, their higher frequency was recorded, as well as the frequency of wet-warm phenotype. Spironolactone dose was higher during hospitalization in the group of patients with ADHF and prediabetes. In the same group, the duration of hospitalization was longer. Prevalence of ADHF with preserved and mildly reduced ejection fraction (EF), severity of LV diastolic dysfunction (DD), LV mass index in patients with BMI >30 g/m2, left atrial volume index, pulmonary artery systolic pressure were significantly higher in the group of patients with ADHF and prediabetes. At a high risk of type 2 diabetes, the concentrations of NT-proBNP, triglyceride/glucose index, cystatin C, LV diastolic dysfunction severity were significantly higher, and the glomerular filtration rate was lower.

Conclusion. The development of ADHF in patients with prediabetes is interrelated with multiple risk factors and comorbidities, characterized by more pronounced congestion, longer hospitalization, predominantly preserved and mildly reduced EF in combination with severe LVDD, LV hypertrophy, and activation of nonspecific inflammation.