bluuebunny/crossref_metadata_2025 huggingface dataset:
Core Analysis and Hydrocarbon Productivity Evaluation of Agbada Formation in X-021 Well, Niger Delta, Nigeria
Authors: EFEMENA Onome Oluwakemi , MAJU-OYOVWIKOWHE Efetobore Gladys
Published: July 2024

This study presents a comprehensive sedimentological and lithological analysis of the X-021 Well in the Niger Delta Basin, Nigeria. The aim was to determine the sedimentological characteristics and hydrocarbon productivity potential of the Agbada Formation. Core samples were obtained from 9710 ft to 9866 ft and analyzed using standard sedimentological procedures. This study identified eighteen lithofacies zones, fourteen associated mineral units, seven heterogenetic zones, and seven homogenetic zones. Four potential reservoir units (PR1, PR2, PR3, and PR4) were delineated, with PR4 exhibiting the highest hydrocarbon occurrence and accumulation. Gamma ray logs were used to interpret sedimentary facies, while porosity log data aided in reservoir evaluation. The study confirmed the presence of effective source rocks, reservoirs, and seals, indicating a robust petroleum system. These findings provide valuable insights for future hydrocarbon exploration and production in the Niger Delta Basin.
The Driving Forces of Road Safety Volunteers: Resilience, Coping Mechanisms, Well-being and Education
Authors: Shamoa-Nir Lipaz
Published: July 2024

Road safety is a critical concern worldwide, impacting individuals, communities, and societies. As mobility rises, so does the risk of accidents and injuries on roads, emphasizing the need for preventive measures. Road safety volunteers are crucial in promoting and upholding road safety, making it vital to understand their motivations and Resilience Sources. This study aims to uncover what drives their commitment and the factors influencing their experiences as volunteers, informing strategies to support and enhance their efforts. Through analysis of 28 interviews with road safety volunteers, several prominent themes emerged. These include diverse motivations, a strong sense of purpose, active community engagement, and a sense of empowerment among volunteers. Additionally, the challenges they face in their roles highlight the considerable resilience these volunteers demonstrate. The importance of support systems—whether individual or peer-based, —in strengthening this resilience was prominently underscored. These findings contribute to the understanding of the importance of promoting education on safe driving practices and fostering active citizen involvement in preventing traffic violations and road accidents.
Mid-crustal melting in Western Yunnan and its influence on extrusion of the Tibetan Plateau
Authors: Zhu Renzhi , Fowler Mike , Harris Nigel , Lai Shaocong , King Jess , Qin Jiangfeng
Published: July 2024

The Himalayan-Tibetan system is growing upward and outward, influenced by mid-lower crustal melting and flow. This study offers a missing geochemical perspective on current geophysics, linking mid-crustal melting beneath SE Tibet to the initiation of transcurrent tectonics that have facilitated the ongoing southeastward extrusion of the Tibetan plateau. New zircon U-Pb data reveal a pulse of Miocene felsic magmatism southeast of the Eastern Himalayan Syntaxis. These have high SiO2, variable but low ɛHf(t) and high δ18O which strongly suggest metasedimentary anatexis. Moderate La/Yb and Sr/Y, with high 87Sr/86Sr(i) and low ɛNd(t) are comparable with mid-lower crust biotite-bearing granitic gneisses. Together with biotite and zircon thermobarometry, these characteristics suggest biotite-dehydration anatexis in the middle crust. Experimental and rheological data suggest melt fractions (> 10%) sufficient to reduce crustal viscosity and allow rheological accommodation for Miocene extrusion of the plateau, and the continued presence of mid-crustal melt is supported by current geophysical data.
Analyzing Non-Monotonic Hazard Rate Data Using the Harris Extended Inverted Lindley Distribution
Authors: Bengalath Jabir , Punathumparambath Bindu
Published: July 2024

In this paper, we introduce a new three-parameter extension of the inverse Lindley distribution known as the Harris extended inverted Lindley (HEIL) distribution, which offers more flexibility in modeling upside-down bathtub lifetime data. Some statistical properties of the proposed model were explicitly derived. These include density and hazard rate functions with their behavior, ordinary and incomplete moments, skewness, kurtosis measures, moment generating functions, reliability properties, and the quantile function. The maximum likelihood estimation of the parameters, their estimated asymptotic distribution and confidence intervals were derived. Renyi entropy as a measure of the uncertainty in the model is derived. The simulation study is conducted to evaluate the performance of the maximum likelihood estimator. Finally, to assess the superiority of the proposed model three real data sets were examined.
Mathematics Subject Classification (2020) 60E05 · 62E10 ·
Wo muss ich klicken?
Authors: Gantenbrink Sina , Knurr Moritz
Published: July 2024

Open Educational Resources (OER) wird in aktuellen Debatten um frei zugängliche Lehre und eine neue «Kultur des Teilens» grosse Bedeutung zugesprochen. So ist eine Öffnung der eigenen Lehre durch Publikation eigener Materialien und Konzepte mittels Creative-Commons-Lizenzen möglich. Jedoch zeigt sich, dass Nutzer:innen von OER immer wieder an gewisse Grenzen stossen. Schon die Suche nach geeigneten und passfähigen Materialien ist aufgrund der Fülle verschiedener Portale mit jeweils eigenen Login-Hürden häufig frustrierend. Wenn aber eine «Kultur des Teilens» etabliert werden soll, so muss es auch entsprechende digitale Räume geben, die einen einfachen Zugang ermöglichen und die sozialen Aspekte von Austausch und Kollaboration (Open Educational Practice) auf digitaler Ebene einbeziehen. Der vorliegende Artikel beschäftigt sich entsprechend mit Gestaltungsprinzipien und -vorschlägen für ein OEP-förderliches digitales Ökosystem, das eine neue Kultur des Teilens von OER auf technischer Ebene unterstützt. Aus den Erfahrungen im Projekt InDigO wurde das Konzept einer «Wunschplattform» abgeleitet, das die generellen Anforderungen an eine OEP-förderliche Online-Plattform bündelt. Die Präsentation dieser Wunschplattform ist Ziel dieses Beitrags zusammen mit der Darstellung der Grundlagen und Erfahrungen, auf denen diese Plattform beruht.
Open Educational Practice – Community-Building im dialogischen Gastaustausch am Beispiel der universitären Standorte Dortmund und Duisburg-Essen
Authors: Becker Veronika , Mammes Ingelore
Published: July 2024

Der Beitrag stellt die im Rahmen des Projekts «InDigO: Inklusion und Digitalisierung im OER-Format lernen, weiterentwickeln und verbreiten» erfolgte kooperative Zusammenarbeit der universitären Standorte Dortmund (Technische Universität Dortmund, TU) und Duisburg-Essen (Universität Duisburg-Essen, UDE) vor. Ausgehend von einer Vielzahl inklusionsorientierter Offener Bildungsressourcen (OER) wurden im Wintersemester 2022/23 vor dem Hintergrund einer Offenen Bildungspraxis (OEP) Teile der Lehre in Form dialogischer Zusammenarbeit gemeinsam gestaltet. Mit dem Ziel einer qualitätsvollen Auseinandersetzung von Studierenden mit Inklusion konnten dazu in fortwährendem Austausch OER zunächst erarbeitet und im Anschluss in der Lehre eingesetzt werden. Eingebettet in das jeweilige Lehrsetting wurden sowohl fachliche Expertisen verknüpft als auch kooperative Strukturen verankert. Am Beispiel des Standorts Duisburg-Essen wird exemplarisch eines dieser dialogisch erarbeiteten Lehrkonzepte beschrieben. Neben einem Einblick in die Zusammenarbeit zeigt der Beitrag in der Kooperation ausgemachte Chancen und Hindernisse des Einsatzes offener Bildungsmaterialien in der lehrer:innenbildenden Hochschullehre auf.
Mapeamento do Surgimento da Temática Corrupção na Área de Governança Corporativa: Uma Revisão Bibliométrica da Literatura
Authors: Lima Anderson Antônio , Ribeiro Thiago de Luca Santana
Published: July 2024

Objetivo: Apesar da evidente importância teórica da governança corporativa como mecanismo de controle de práticas de corrupção, até onde sabemos não há artigos revisionais que relacionam estas temáticas. Neste sentido, o objetivo deste artigo é mapear o surgimento e a evolução da temática corrupção na área de governança corporativa e apresentar o estado da arte e as tendências de estudos futuros sobre estas temáticas.
Métodos:  Este artigo é uma revisão bibliométrica, trata-se de um método de análise estatística que fornece uma compreensão quantitativa da literatura acadêmica sobre um determinado campo científico. As técnicas bibliométricas utilizadas são a análise de cocitação e análise de pareamento bibliográfico. Ou seja, buscou-se compreender as raízes teóricas e identificar as fronteiras do conhecimento.
Resultados: Na análise de cocitação foram identificados 4 clusters teóricos (bases teóricas) e no pareamento 6 clusters teóricos (fronteiras do conhecimento). Percebe-se pelos mapeamentos gráficos que as pesquisas atuais (fronteiras) possuem mais congruência entre os diferentes temas, enquanto as pesquisas que formam as bases teóricas são mais idiossincráticas.  
Originalidade/Relevância: Até onde sabemos, este é um dos primeiros artigos a estocar o conhecimento sobre corrupção na área de governança corporativa e clusterizar em bases e fronteiras teóricas.
Contribuições teóricas/metodológicas: A análise de pareamento identificou como principais temas em voga: Divulgação de relatórios de sustentabilidade; Teorias Institucional; Conexões políticas; Mecanismos de Controle de Governança Corporativa; Cultura nacional; Investimentos estrangeiros; Desempenho organizacional; Papel financeiro; Fatores determinantes de suborno; e papel das agências nacionais e internacionais de regulações.
Combate a corrupção: uma articulação teórica dos temas responsabilidade social, governança corporativa e teoria da agência
Authors: Machado Monica Cristina Rovaris , Carlos Santos Ruan , Raupp Fabiano Maury
Published: July 2024

Objetivo: A corrupção, tida como o abuso ou uso indevido de poder ou confiança para benefício próprio, em vez do propósito para o qual esse poder ou confiança foi concedido, tem acarretado problemas a muitos países e os princípios de Responsabilidade Social e da Governança Corporativa tem sido apontada na literatura como um agente mitigador desse problema. De outro lado, outras pesquisas indicam a necessidade de se ter cautela ao se pautar pela mentalidade da Teoria da Agencia que a defende como um instrumento neutro e suficiente para mitigar os problemas de corrupção.
Métodos: Este estudo consiste em um ensaio teórico baseado em uma pesquisa bibliográfica que expõe a temática Corrupção, Responsabilidade Social, Governança Corporativa e Teoria da Agencia, levantando as diferentes definições, linhas de pesquisas, linhas de pensamento, teorias de sustentação, dualidades e conflitos existentes em torno do mainstream.
Resultados: A justificativa para o estudo está centrada na percepção de que existem estudos que se dedicaram a testar empiricamente a relação existente entre a corrupção e o ambiente contábil dos países, mas poucos foram os estudos que se dedicaram a refletir criticamente sobre o conhecimento produzido acerca dessa relação.
Originalidade/Relevância: No contexto apresentado, uma boa estrutura de Governança torna-se recomendável para uma eficaz administração e gestão nos órgãos em combate corrupção. Foi possível perceber que os princípios da Governança Corporativa e da Responsabilidade Social, sendo Transparência (disclosure), Prestação de Contas (accountability) e Equidade (fairness) vão de encontro aos princípios da Teoria da Agencia, principalmente relacionados a ética e moralidade nas relações interpessoais das organizações.
Contribuições teóricas/metodológicas: A análise de pareamento identificou como principais temas em voga: Divulgação de relatórios de sustentabilidade; Teorias Institucional; Conexões políticas; Mecanismos de Controle de Governança Corporativa; Cultura nacional; Investimentos estrangeiros; Desempenho organizacional; Papel financeiro; Fatores determinantes de suborno; e papel das agências nacionais e internacionais de regulações.
The Surprising Microscopic Wonders from the Depths of Villefranche-sur-Mer
Authors: Dolan John R.
Published: July 2024

The Institut de la Mer de Villefranche is located near deep Mediterranean waters, and so is well-placed for investigations of the fauna of the deep sea. Shown here are some rare images of living microscopic organisms that populate the deep sea. Each shows a beautiful and complex morphology, and some images show unexpected features.
Intangible Space of Continuity and Changes in Ondel-Ondel’s Costume Elements and Performance
Authors: Wahidiyat Mita Purbasari , Carollina Donna , Marianto Martinus Dwi , Triatmodjo Suastiwi
Published: July 2024

The research discussed Ondel-ondel, a significant and tall doll from Betawi, since the costume elements could be changed anytime, anywhere, and in any shape, Ondel-ondel appeared more alive and appealing in different looks. Initially, Ondel-ondel seemed too unchanged, but it was prettier than before. There were many Ondel-ondel performances in Jakarta's streets that were not accompanied by music. Ondel-ondel transformed not only the costumes but also the myth from repellent to entertainer. The changes were exciting to discover the concept or idea of its background, relationships, impacts on the environment, and other meanings for society. The research applied a descriptive qualitative method. Based on a historical approach with semiotic analysis and interpretation as a research method, Ondel-ondel costume elements underwent continuity and changed alongside the social, political, economic, and cultural contexts linked to the role of power of its respective time. Within the continuity and changes in each Ondel-ondel model, there was a compromise and social dynamic in society, which gave the costume elements a unique trade. This compromise created a cultural negotiation space in the community and helped to develop a typical environment that distinguished itself from others. The result is four Ondel-ondel models, each representing society's compromise and the social dynamic between the authorities, the community, and the Ondel-ondel players. When the transformation of the ondel-ondel's appearance creates an intangible space between maintaining its ideology. Meanwhile, on the other hand, the changes in ondel-ondel portray how the changing times also alter the appearance of the ondel-ondel.
Boas práticas na administração de medicamentos via sondas em neonatos: Estudo transversal
Authors: Higa Carla Moreira Lorentz , Cheade Maria de Fátima Meinberg , Frota Oleci Pereira , Cardoso Andréia Insabralde de Queiroz
Published: July 2024

Na literatura existem estudos relacionados à administração de medicamentos via sondas gástricas e enterais que descrevem falhas, sobretudo nas unidades de atendimento ao paciente adulto, enquanto nas unidades neonatais as pesquisas são escassas. O estudo objetivou avaliar o grau de adequação das boas práticas no processo de administração de medicamentos via sondas gástricas e enterais realizados pela Enfermagem em neonatos. Trata-se de um estudo de abordagem quantitativa e de corte transversal realizado em um serviço de neonatologia de um hospital público de ensino de Mato Grosso do Sul. Os dados foram coletados de janeiro a abril de 2019, por roteiro observacional baseado nas recomendações da American Society for Parenteral and Enteral Nutrition. Um terço dos processos (33,7%) foram classificados como não adequados. Os técnicos de enfermagem aderiram menos às boas práticas recomendadas quando comparados aos enfermeiros (p=0,02) e aqueles que trabalham no período diurno apresentaram mais inadequações quando comparados ao período noturno (p=0,01). Percebe-se que a equipe de enfermagem precisa aderir de maneira integral às boas práticas recomendadas para a administração de medicamentos, para diminuir os riscos de possíveis eventos adversos que possam atingir os neonatos.
Flood assessment using machine learning and its implications for coastal spatial planning in Phu Yen Province, Vietnam
Authors: Tran Van Truong , Nguyen Huu Duy , Ngoc Dang Thi , Quan Du Vu Viet , Huan Nguyen Cao , Thanh Pham Viet , Van Liem Ngo , Nguyen Quoc-Huy
Published: July 2024

The objective of this study was the development of a new machine learning model using a radial basis function neural network (RBFNN) to build flood susceptibility maps and damage assessment for the Phu Yen province of Vietnam. The built model will be optimized by five algorithms, namely Giant Trevally Optimization (GTO), Golden Jackal Optimization (GJO), Brown-Bear Optimization (BBO), Gray Wolf Optimizer (GWO), and Whale Optimization Algorithm (WOA) to find out the best model to establish the flood susceptibility map. These models were evaluated using the statistical indices such as root mean square error (RMSE), mean absolute error (MAE), receiver operating characteristic (ROC), area under the curve (AUC), and coefficient of determination (COD). The result showed that all five optimization algorithms were successfully improving the performance of the RBFNN model, among them the hybrid model RBFNN–BBO has the highest performance with AUC = 0.998 and R2 = 0.8 and the RBFNN–GTO model has the lowest performance with AUC = 0.755 and R2 = 0.65. The regions identified with a high- and very-high flood susceptibility area (1,075 km2) were concentrated on the plain and along three of the largest rivers in Phu Yen province.
Experimental study to understand the effects of deficit irrigation in maize
Authors: Sudesan Soorya , Sonkar Ickkshaanshu , K. S. Hari Prasad , Chandra Shekhar Prasad Ojha
Published: July 2024

Given the challenges posed by climate change and the scarcity of water, it is essential to adopt sustainable irrigation practices that do not compromise crop yields. Research studies are crucial to determine the optimal deficit soil moisture levels to be maintained for cultivation in different soil types. This study examines the response of maize grown on loamy sand soil under different water deficit moisture contents by monitoring the variation of the crop growth in terms of the leaf area index, biomass weight, root depth and yield. The daily soil moisture is measured to understand the actual evapotranspiration from the study plots. From the experiments, the optimal moisture content identified is 13%, and the plot maintained at this moisture content has shown the highest evapotranspiration, yield and biomass. The yield response factor of the maize grown in water deficit conditions is also observed to be very close to the value reported by FAO. As expected, the yield response factor is found to be sensitive to water stress. The deficit irrigation at the optimal moisture content of 13% could be recommended for maize cultivation in loamy sand soil in North Indian climatic conditions. Such considerations will be vital for achieving sustainable irrigation goals.
Monitoring the effects of climate change and topography on vegetation health in Tharparkar, Pakistan
Authors: Hassan Sher Shah , Goheer Muhammad Arif , Farah Humera , Nadeem Momana , Muazzam Aleeza , Munir Jahan Ara , Fatima Saba
Published: July 2024

Pakistan's geographic position and socioeconomic profile make it one of the nations that are particularly susceptible to the negative effects of climate change. The Tharparkar district in Pakistan is of particular importance in this regard as it is an arid region with serious environmental issues like drought, desertification, and soil degradation. Therefore, the purpose of this study is to examine how topographic and climatic factors affect vegetation indicators in the Tharparkar. The study utilizes spatiotemporal data spanning over 20 years (2001–2020) collected from the satellites MOD11A2 and MOD13A3. The collected data are processed using a range of tools in ArcGIS 10.4.1, and the impact of topographic and climatic conditions is analyzed based on different vegetation indices, including EVI, NDVI, STVI, OSAVI, and SAVI. The findings reveal that temperature and precipitation, both of which are controlled by topographic features, such as elevation and slope, are the key elements affecting vegetation in Tharparkar. At high elevations, rainfall (>440 mm) and LST (>39 °C) are also high and where the slope is low the density of vegetation indices is high.
Application of decision support system/remote sensing/GIS techniques in groundwater recharge assessment
Authors: Saad Mohamed , Nofal Eman , Abdelmonem Yehia , Riad Peter
Published: July 2024

Managing water resources and storing water through the identification of groundwater recharge zones (GWRZs) are critical to water security in Egypt. Decision-support systems (DSSs), remote sensing, and GIS techniques have yielded significant data for water resources modeling. The geologic, geomorphic, climatic, and hydrologic features of the Toshka area, Western Lake Nasser, Egypt, have been generated by data from Shuttle Radar Topography Mission, Climatic Research Unit gridded Time Series, Sentinel 2 time series, and Landsat-8 OLI. Fifteen GIS thematic maps have been ranked and normalized using five DSS techniques: Analytical Hierarchy Process (AHP), Fuzzy Analytical Hierarchy process (FAHP), Frequency Ratio (FR), Shannon Entropy (SE), and Multi-Influencing Factor (MIF). To ensure the computational usefulness of these models, GWRZs have been extracted and compared. The outcomes showed that 83, 87.5, 99.1, 99.1, and 87.5% of the existing wells are in high to extreme GWRZs for AHP, FAHP, FR, SE, and MIF, respectively. The receiver operating characteristic curve (ROC) was used to assess the effectiveness of these models. It was found that the SE model had the highest predictive performance rates, as its ROC accuracy value was 91.1%, while the FR, AHP, FAHP, and MIF approaches had values of 91, 84.4, 81.9, and 89.9%, respectively.
Design, Synthesis, Cytotoxicity Profiling, Molecular Docking and ADMET Studies of Novel Functionalized Coumarin-pyrazole-thiazole Hybrids: Cyclization of Chromonyl Thiazolyl Pyrazolyl Thiosemicarbazone with α-Halocarbonyl Reagents
Authors: Ali Tarik E. , Alsolimani Ayat K. , Assiri Mohammed A. , Shati Ali A. , Alfaifi Mohammad Y. , Elbehairi Serag E. I.
Published: July 2024

:

A simple synthetic method was performed to design a novel series of polycyclic
systems consisting of a coumarin-pyrazole-thiazole skeleton linked with a completed thiazole
ring via hydrazone linkage. The methodology depended on the cyclization of the active
precursor 2-[(3-(2-oxo-2H-chromen-3-yl)-1-(4-phenylthiazol-2-yl)-1H-pyrazol-4-yl)methylene]
hydrazine-1-carbothioamide (2) by its reaction with a series of α-halocarbonyl reagents
under Hantzsch reaction conditions. The spectral and analytical data confirmed the structures
of all the synthesized compounds. The target compounds were screened for their in
vitro anticancer activity. The cytotoxic effects of obtained compound were screened against
cancer cell lines (MCF-7, HepG2, and HCT116) using the standard SRB method. Furthermore,
products 4, 5, and 7b were the most active against all cancer cell lines, compared
with Doxorubicin. These bioactive products effectively suppress the growth of cancer cells by activating the
cell death program through late apoptosis. In addition, products 4 and 5 arrested the cell cycle at the S and G2
phases, while product 7b has the ability to arrest the cell cycle at the G2 phase against all three cancer cells. The
molecular docking of the products 4, 5, and 7b showed good binding affinities with Cyclin-dependent kinase 8
(CDK-8), while the ADMET prediction supported that these bioactive products can be promising anticancer
agents.
Heteroaromatization of Coumarin Part III: One-pot Synthesis, Antitumor Activity, DFT Studies, and Molecular Docking of Coumarin Derivatives
Authors: Alamri Abdullah A. , Borik Rita M.A. , Abd El-Wahab Ashraf H.F. , Al-Dies Al-Anood M. , Mohamed Hany M. , Ibrahim Diaa A.
Published: July 2024

:

A one-pot three/two-component reaction of 3-acetyl-coumarin (1), 4/3-
anisaldehyde (2a,b) and malononitrile or 3-acetylcoumarin (1) and 2-(4/3-
methoxybenzylidene)malononitrile (5a,b) in glacial acetic acid/ammonium acetate under
reflux afforded 2-amino-4-(4/3-methoxyphenyl)-6-(2-oxo-2H-chromen-3-yl)nicotinonitrile
(4a,b). Spectral data helped establish the structures of the compounds. Subsequently, an
antiproliferative evaluation against a selected line of tumorous cells (HepG-2, MDA-MB-
231 and A549) was performed in-vitro for the novel 2-amino-4-(4/3-methoxyphenyl)-6-(2-
oxo-2H-chromen-3-yl)nicotinonitrile (4a,b). Compound 4a exhibited good efficiency
against the MDA-MB-231 and A549 cell lines compared with the reference drug (Vinblastine).
Furthermore, the chemical reactivity of both compounds was discussed using DFT.
Lastly, a molecular docking analysis was addressed and conducted for these desired molecules.
Efficacy Analysis of PTCD + TACE vs PTCD + Apatinib in the Treatment of HCC with Obstructive Jaundice: A Retrospective Study
Authors: Lu Haohao , Liang Bin , Xia Xiangwen , Zheng Chuansheng
Published: July 2024

Purpose:

The aim was to evaluate the safety and effectiveness of PTCD combined with TACE in the
treatment of hepatocellular carcinoma with obstructive jaundice and to compare the efficacy of TACE in patients
with different levels of bilirubin after PTCD.

Methods:

The clinical data of 141 patients with HCC complicated with obstructive jaundice were analyzed retrospectively.
The patients underwent PTCD first. When the total bilirubin decreased, the patients received TACE or
Apatinib treatment. They were divided into two groups: (1) PTCD+TACE group, N=68; (2) PTCD+Apatinib
group, N=73.

Results:

The PTCD+TACE group had higher ORR and DCR than the PTCD+Apatinib group (57.4% vs 12.3%, p
< 0.001; 80.9% vs 60.3%, p = 0.010). The mPFS of the PTCD+TACE group was longer than that of the
PTCD+Apatinib group (7.1 months vs 3.8 months, p < 0.001). The mOS of the PTCD+TACE group was longer
than that of the PTCD+Apatinib group(11.5 months vs 7.7 months, p < 0.001). In the subgroup analysis of the
PTCD+TACE group, the results showed that the survival benefits of the groups with total bilirubin <2 times and
2-3 times were greater.

Conclusion::

In patients with HCC and obstructive jaundice, superselective TACE(lipiodol+epirubicin emulsion)
significantly prolonged OS and PFS compared with Apatinib after using PTCD to reduce total bilirubin to
<100 μmol/L. Patients whose total bilirubin dropped to ≤3 times of the upper limit of normal value after PTCD
had longer OS and PFS than patients >3 times.
Formulation and Evaluation of Polyherbal Antidandruff Shampoo
Authors: Handa Uditi , Sharma Deepika , Dubey Abhilasha , Nagpal Kajal , Sharma Prerna , Rani Nidhi , Mittal Vishnu
Published: July 2024

Introduction:

Nowadays, most people are suffering from dandruff which when not treated becomes flaky and causes major damage to the scalp of a person. Dandruff is a common scalp illness caused by the yeast Pittosporum. It is not possible to completely eradicate dandruff; it can only be appropriately handled.

Methods:

When used as indicated, a shampoo's surfactant, often referred to as a surface-active agent, in its proper form—liquid, solid, or powder—will safely remove skin fragments, dirt, and surface oil from the scalp and hair shaft. Numerous hair care solutions use a variety of anti-fungal substances to treat dandruff. Many adverse reactions to these products have been reported, includ-ing hair loss, heightened headache, nausea, scaling, itching, and irritation.

Results:

Thus, an attempt was undertaken to develop a herbal anti-dandruff shampoo form safe and more successful in treating the dandruff problem by using a marketed herbal tincture. The anti-dandruff formulation was prepared by combining natural polyherbal tincture, and these tincture shows the different medicinal effects on hair.

Conclusion:

A number of parameters, including visual observation, pH, consistency, particle per-centage, filth dispersion, surface phenomena, and foaming content were used to assess the shampoo formulations. Also, the estimation of an anti-microbial activity by using the inoculation method. The greatest zone of inhibition demonstrated a strong antimicrobial effect for the formulation.
Surviving at a Falling Transportation Industry with the Help of Emotional Relationship with your Customers
Authors: Yurtseven Çağlar
Published: July 2024

Introduction

Public intercity transportation is an example of a rapidly evolving industry. In developing countries, we observe the increasing popularity of airlines, whereas bus lines start to lose their significance.

Methods

The successive bankruptcy of bus companies, which have made a large amount of investment and provided significant employment, is a case worth examining. This article offers a case study from the Turkish public intercity transportation industry in which a bus company distinguishes itself by becoming a love brand with the relationship it establishes with its customers. The case shows that the emotional relationship established during the ups and downs of sectors have become insurance that protects companies during the downturn.

Results

To support our argument, we estimated the occupancy rates of bus companies based on characteristics such as ticket price, travel time, existence of catering service, social media interaction, and year of establishment. We found that the significant variables explaining occupancy rates are the companies' founding year and positive social media interaction frequency.

Conclusion

In an estimation where even the price is not a significant variable at the 0.01 level, the significance of the above-mentioned variables shows that relationship-based dynamics can be important demand determinants in a conventional transportation sector.
Vozes que moldam Abril: Os discursos presidenciais na celebração da Revolução
Authors: Marques Maria Aldina , Ramos Rui , Duarte Isabel Margarida , Roboredo Seara Isabel , Pinto Alexandra Guedes , Pinto Rosalice
Published: July 2024

A democracia, em Portugal, tem data de nascimento. Vozes que moldam Abril tem como objetivo primeiro assinalar os 50 anos do 25 de Abril, na atenção aos discursos presidenciais de comemoração da Revolução, realizados maioritariamente na Assembleia da República Portuguesa. Concordamos com Balandier (1992) quando sublinha a importância simbólica da dimensão cerimonial na manutenção do poder. Em eventos de celebração nacional, os discursos amplificam esta dimensão. Os discursos presidenciais são lugar de legitimação e credibilização da função de Presidente da República, cujo poder se materializa, assim, no exercício público e institucional da palavra. Não se pode dissociar o que o Presidente diz dos modos linguísticos, discursivos, como o diz, do contexto onde o diz ou dos destinatários do que diz. A pertinência e importância da investigação realizada assenta no pressuposto de que os discursos, todos os discursos, não são transparentes, não são simples espelho do mundo, antes são modos particulares de o construir, a partir de um olhar marcado por dimensões experienciais, sociais e culturais, entre outras. Por isso, analisar os modos como são construídos os discursos presidenciais de celebração do 25 de Abril é um contributo central para o conhecimento do seu lugar na História de Portugal, a partir dos olhares privilegiados dos presidentes da República, cujas vozes, sem dúvida, moldam Abril. Este livro, que reúne pesquisas de investigadores em Ciências da Linguagem, é a nossa forma comum de celebrarmos Abril e os 50 anos da democracia portuguesa.
Circulaire transitie: ruimtelijke transformatie
Authors: Bomas Bart , Boddeke Jorick , Kolenberg Jonas , Heestermans Luc , Hulsker Walter
Published: July 2024

De transitie naar een circulaire economie (CE) betekent grote veranderingen voor de wijze waarop we produceren en consumeren. Een onderbelicht aspect van CE is de ruimtelijke opgave die hieraan verbonden is en de rol van ruimtelijke ordening en sturing. Zonder een ruimtelijk-economisch perspectief en bijpassende strategie voor de ruimtelijke ontwikkeling blijven circulaire doelen buiten bereik. In dit paper laten we aan de hand van vier praktijkvoorbeelden zien hoe ruimtelijke consequenties van de circulaire transitie kunnen doorwerken in beleid- en strategievorming. En hoe lessen uit de praktijk gebruikt kunnen worden voor verdere theorie- en beleidsvorming. Uit de casus komt een beeld naar voren waarin ruimtelijke strategievorming op regioniveau, een multi-stakeholder aanpak en het centraal stellen van omgevingskwaliteit belangrijke succesfactoren zijn voor het realiseren van de circulaire transitie die in balans is met gebiedskarakteristieken en omgevingskwaliteit.
Development of Party Makeup Tutorial Video
Authors: Alifia Yayi Pitakusuma  , Eni Juniastuti
Published: July 2024

The goals of this study are as follows: (1) formulating a plan for making a video instruction on party makeup secondly, making a tutorial video for applying makeup for a party (3) learning how to do party makeup via a video lesson with no effort. Development approach for 4D models used in research and development. The process of finding, gathering, and creating makeup-related ideas is defined as (1). (2) preparation for the design, layout of the makeup, storyboards, filming, dubbing, and editing. (3) conduct small-scale testing and validation. (4) distribute the evaluation surveys and accompanying images and videos. From February to July of 2023, the research was conducted. A panel of thirty Miss Bantul judges checked the video tutorial for appropriateness from the perspectives of media specialists, subject matter experts, and end users. Qualitative and quantitative descriptive analysis, as well as interviewing and observing participants, are used to gather data. Final Product develop a strategy for making a video instructional that covers all the bases, from coming up with a flawless makeup look (design 1) to creating a storyboard, filming, and editing (2). Incorporate an introduction, main body, and closing sequence into a 17-minute and 34-second video and share it using the following URL: https://youtu.be/icHL7dDhBgw (3). The material experts' result is 95.1%, the media experts' result is 95.3%, and Miss Bantul's result is 95.1%. The 98.8% group is highly doable. Consequently, creating video guides on how to apply party makeup is a great idea.
Pengaruh Pendekatan Kontekstual terhadap Kemampuan Pemecah Masalah Matematika pada Materi Bangun Ruang Sisi Lengkung
Authors: Laili Dini Nur , Sari Liliyana Indah Puspita , Adawiya Robiatul
Published: July 2024

This research aims to evaluate the effect of a contextual approach on students' mathematical problem solving abilities in curved geometric shapes. The literature review (SLR) study method was used to analyze 6 scientific articles relevant to the research topic. This research identifies themes and patterns that emerge regarding the influence of a contextual approach on students' mathematical problem solving abilities. The results of the analysis show that the application of the contextual approach has a positive influence on students' mathematical problem solving abilities. Comparison table of scores for the experimental group achieved higher achievement than the control group. Data visualization graphs also reinforce these findings. The conclusion of this research confirms that the application of a contextual approach has a positive impact on solving mathematical problems in curved geometric shapes. The implications of these findings can be a guide for educators and researchers to enrich mathematics learning strategies by integrating everyday life contexts into geometry teaching
Immersive Virtual Reality Use in Medical Intensive Care: Mixed Methods Feasibility Study
Authors: Locke Brian W , Tsai Te-yi , Reategui-Rivera C Mahony , Gabriel Aileen S , Smiley Aref , Finkelstein Joseph
Published: July 2024

Background

Immersive virtual reality (VR) is a promising therapy to improve the experience of patients with critical illness and may help avoid postdischarge functional impairments. However, the determinants of interest and usability may vary locally and reports of uptake in the literature are variable.

Objective

The aim of this mixed methods feasibility study was to assess the acceptability and potential utility of immersive VR in critically ill patients at a single institution.

Methods

Adults without delirium who were admitted to 1 of 2 intensive care units were offered the opportunity to participate in 5-15 minutes of immersive VR delivered by a VR headset. Patient vital signs, heart rate variability, mood, and pain were assessed before and after the VR experience. Pre-post comparisons were performed using paired 2-sided t tests. A semistructured interview was administered after the VR experience. Patient descriptions of the experience, issues, and potential uses were summarized with thematic analysis.

Results

Of the 35 patients offered the chance to participate, 20 (57%) agreed to partake in the immersive VR experience, with no difference in participation rate by age. Improvements were observed in overall mood (mean difference 1.8 points, 95% CI 0.6-3.0; P=.002), anxiety (difference of 1.7 points, 95% CI 0.8-2.7; P=.001), and pain (difference of 1.3 points, 95% CI 0.5-2.1; P=.003) assessed on 1-10 scales. The heart rate changed by a mean of –1.1 (95% CI –0.3 to –1.9; P=.008) beats per minute (bpm) from a baseline of 86.1 (SD 11.8) bpm and heart rate variability, assessed by the stress index (SI), changed by a mean of –5.0 (95% CI –1.5 to –8.5; P=.004) seconds–2 from a baseline SI of 40.0 (SD 23) seconds–2. Patients commented on the potential for the therapy to address pain, lessen anxiety, and facilitate calmness. Technical challenges were minimal and there were no adverse effects observed.

Conclusions

Patient acceptance of immersive VR was high in a mostly medical intensive care population with little prior VR experience. Patients commented on the potential of immersive VR to ameliorate cognitive and emotional symptoms. Investigators can consider integrating minimally modified commercial VR headsets into the existing intensive care unit workflow to further assess VR’s efficacy for a variety of endpoints.
Evaluating and Enhancing Large Language Models’ Performance in Domain-Specific Medicine: Development and Usability Study With DocOA (Preprint)
Authors: Chen Xi , Wang Li , You MingKe , Liu WeiZhi , Fu Yu , Xu Jie , Zhang Shaoting , Chen Gang , Li Kang , Li Jian
Published: July 2024

BACKGROUND

The efficacy of large language models (LLMs) in domain-specific medicine, particularly for managing complex diseases such as osteoarthritis (OA), remains largely unexplored.

OBJECTIVE

This study focused on evaluating and enhancing the clinical capabilities and explainability of LLMs in specific domains, using OA management as a case study.

METHODS

A domain-specific benchmark framework was developed to evaluate LLMs across a spectrum from domain-specific knowledge to clinical applications in real-world clinical scenarios. DocOA, a specialized LLM designed for OA management integrating retrieval-augmented generation and instructional prompts, was developed. It can identify the clinical evidence upon which its answers are based through retrieval-augmented generation, thereby demonstrating the explainability of those answers. The study compared the performance of GPT-3.5, GPT-4, and a specialized assistant, DocOA, using objective and human evaluations.

RESULTS

Results showed that general LLMs such as GPT-3.5 and GPT-4 were less effective in the specialized domain of OA management, particularly in providing personalized treatment recommendations. However, DocOA showed significant improvements.

CONCLUSIONS

This study introduces a novel benchmark framework that assesses the domain-specific abilities of LLMs in multiple aspects, highlights the limitations of generalized LLMs in clinical contexts, and demonstrates the potential of tailored approaches for developing domain-specific medical LLMs.
Text Messaging Versus Postal Reminders to Improve Participation in a Colorectal Cancer Screening Program: Randomized Controlled Trial (Preprint)
Authors: Vives Nuria , Binefa Gemma , Travier Noemie , Farre Albert , Panera Jon Aritz , Casas Berta , Vidal Carmen , Ibáñez-Sanz Gemma , Garcia Montse ,   M-TICS research group
Published: July 2024

BACKGROUND

Mobile phone SMS text message reminders have shown moderate effects in improving participation rates in ongoing colorectal cancer screening programs.

OBJECTIVE

This study aimed to assess the effectiveness of SMS text messages as a replacement for routine postal reminders in a fecal immunochemical test–based colorectal cancer screening program in Catalonia, Spain.

METHODS

We conducted a randomized controlled trial among individuals aged 50 to 69 years who were invited to screening but had not completed their fecal immunochemical test within 6 weeks. The intervention group (n=12,167) received an SMS text message reminder, while the control group (n=12,221) followed the standard procedure of receiving a reminder letter. The primary outcome was participation within 18 weeks of the invitation. The trial was stopped early, and a recovery strategy was implemented for nonparticipants in the intervention group. We performed a final analysis to evaluate the impact of the recovery strategy on the main outcome of the trial. Participation was assessed using a logistic regression model adjusting for potential confounders (sex, age, and deprivation score index) globally and by screening behavior.

RESULTS

The trial was discontinued early in September 2022 due to the results of the interim analysis. The interim analysis included 5570 individuals who had completed 18 weeks of follow-up (intention-to-treat). The SMS text message group had a participation rate of 17.2% (477/2781), whereas the control group had a participation rate of 21.9% (610/2789; odds ratio 0.71, 95% CI 0.62-0.82; P<.001). As a recovery strategy, 7591 (72.7%) out of 10,442 nonparticipants in the SMS text message group had an open screening episode and received a second reminder by letter, reaching a participation rate of 23% (1748/7591). The final analysis (N=24,388) showed a participation rate of 29.3% (3561/12,167) in the intervention group, which received 2 reminders, while the participation rate was 26.5% (3235/12,221) in the control group (odds ratio 1.16, 95% CI 1.09-1.23; P<.001).

CONCLUSIONS

Replacing SMS text messages with reminder letters did not increase the participation rate but also led to a decline in participation among nonparticipants 6 weeks after the invitation. However, sending a second reminder by letter significantly increased participation rates among nonparticipants within 6 weeks in the SMS text message group compared with those who received 1 postal reminder (control group). Additional research is essential to determine the best timing and frequency of reminders to boost participation without being intrusive in their choice of participation.

CLINICALTRIAL

ClinicalTrials.gov NCT04343950; https://www.clinicaltrials.gov/study/NCT04343950
Variasi Bahasa Dalam Film Keluarga Cemara: Kajian Sosiolinguistik
Authors: Latifa Zuhra , Frantiko Dika , Qomariyah Laili Nur
Published: July 2024

Language and age is a sociolinguistic realm that discusses how language can distinguish a person's status in the context of age. Differences within human groups often arise due to age, which can give rise to variations in social dialects and provide distinctive characteristics within certain communities. This study tries to reveal the role of age in determining the use of language in the speech of characters in the film Keluarga Cemara. This research was conducted with a sociolinguistic approach using qualitative descriptive methods. This study found that language can distinguish humans into four groups: children, adolescents, adults, and the elderly. Language in children is characterized by word shrinkage and has a characteristic sound. In adolescence language has begun to vary and unique, adolescents are accustomed to presenting new languages that are created based on the results of their creativity. In adulthood is a phase when language begins to improve, because of its authority as an adult regularity, linguistic rules begin to be considered. In the elderly, communication competence begins to be low and turns into topics about medicine and physical.
Prevalensi dan Penyebab Gangguan Muskuloskeletal pada Pengayuh Sampan
Authors: Hartono Hartono , Simangunsong Pahala Maringan Jubel , Manalu Putranto , Pratama Irza Haicha , Aulia Yuli
Published: July 2024

Latar Belakang: Studi mengenai gangguan muskuloskeletal yang diakibatkan oleh aktivitas mendayung perahu atau sampan pada atlit atau nelayan telah banyak dilakukan. Namun, studi yang berfokus pada pendayung sampan untuk jasa transportasi masih terbatas. Aktivitas mendayung yang berat dapat mengakibatkan gangguan muskuloskeletal sehingga menurunkan kualitas hidup pekerja dan merusak kesehatan fisik dan mental mereka.Tujuan: Penelitian ini bertujuan untuk menganalisis hubungan usia, durasi kerja dan masa kerja dengan gangguan muskuloskeletal pada pendayung sampan.Metode: Penelitian ini menggunakan desain cross-sectional yang dilakukan selama bulan Januari 2021. Sebanyak 30 orang disertakan dalam pengukuran dan pengumpulan data. Pengumpulan data menggunakan kuesioner Nordic Body Map dan selanjutnya dianalisis secara statistik menggunakan uji Chi Square.Hasil: Hasil analisis menunjukkan sebanyak 12 pendayung sampan transportasi (40%) mengalami gangguan muskuloskeletal. Keluhan yang timbul pada pendayung adalah pada bagian punggung, pinggang, bahu, lengan atas, lengan bawah, paha, dan pergelangan kaki. Dari hasil uji Chi Square terlihat bahwa keseluruhan faktor risiko seperti usia (p value =0,044), durasi kerja (p value=0,025), dan masa kerja (p value=0,016) berpengaruh terhadap gangguan muskuloskeletal.Kesimpulan: Pendayung sampan berisiko mengalami gangguan muskuloskeletal, sehingga perlu adanya penambahan jam istirahat dan melakukan peregangan otot.
Scoping Review Sex Education untuk Mencegah Kekerasan Seksual pada Anak Usia Dini
Authors: Listriyati Linda , Adnani Qorinah Estiningtyas Sakilah , Susiarno Hadi
Published: July 2024

Latar Belakang: Pendidikan seksual pada anak usia dini menjadi hal yang penting dilakukan pada saat ini, mengingat banyak terjadinya kasus-kasus kekerasan seksual yang terjadi pada anak usia dini.Tujuan: Review Article ini mencoba untuk mengeksplorasi metode-metode ataupun media yang efektif dalam memberikan pendidikan seksual pada anak usia dini sebagai langkah preventif untuk mencegah kekerasan seksual.Metode: Metode Scoping Review digunakan untuk mengidentifikasi literatur yang relevan dari berbagai sumber terkait topik penelitian ini. Langkah-langkah yang dilakukan mencakup identifikasi pertanyaan penelitian, pencarian artikel, seleksi, pemetaan data, dan penyusunan informasi. Dipilih 10 artikel yang memenuhi kriteria inklusi dan ekslusi.Hasil: Analisis data menunjukkan bahwa beberapa metode efektif dalam memberikan pendidikan seksual pada anak usia dini meliputi penggunaan media aplikasi game, lembar kerja anak, lagu tradisional, buku bergambar, dan program pendidikan kesehatan seksual. Hasil penelitian menunjukkan bahwa pendidikan seks pada usia dini dapat meningkatkan pemahaman anak tentang tubuh, perbedaan gender, keselamatan, dan perlindungan diri dari kekerasan seksual. Peran orang tua dan pendidik sangat penting dalam memberikan pendidikan seksual kepada anak usia dini.Kesimpulan: Pendidikan seks pada anak usia dini merupakan langkah penting dalam mencegah kekerasan seksual dan perlu diterapkan dengan berbagai metode yang sesuai dengan perkembangan anak.