bluuebunny/crossref_metadata_2025 huggingface dataset:
Performance evaluation of automated scoring for the descriptive similarity response task
Authors: Oka Ryunosuke , Kusumi Takashi , Utsumi Akira
Published: March 2024

We examined whether a machine-learning-based automated scoring system can mimic the human similarity task performance. We trained a bidirectional encoder representations from transformer-model based on the semantic similarity test (SST), which presented participants with a word pair and asked them to write about how the two concepts were similar. In Experiment 1, based on the fivefold cross validation, we showed the model trained on the combination of the responses (N = 1600) and classification criteria (which is the rubric of the SST; N = 616) scored the correct labels with 83% accuracy. In Experiment 2, using the test data obtained from different participants in different timing from Experiment 1, we showed the models trained on the responses alone and the combination of responses and classification criteria scored the correct labels in 80% accuracy. In addition, human–model scoring showed inter-rater reliability of 0.63, which was almost the same as that of human–human scoring (0.67 to 0.72). These results suggest that the machine learning model can reach human-level performance in scoring the Japanese version of the SST.
A pipeline contributes to efficient identification of salivary proteins in short-headed planthopper, Epeurysa nawaii
Authors: Wang Xiao-Jing , Li Qiao , Ye Zhuang-Xin , Huang Hai-Jian
Published: March 2024

Saliva, an oral secretion primarily originating from salivary glands (SGs), exert critical roles in the ongoing evolutionary interaction between insects and plants. However, identifying insect salivary components poses challenges due to the tiny size of insects, low secretion amounts, and the propensity for degradation after secretion. In this study, we developed a transcriptome-based approach to comprehensively analyze the salivary proteins of the short-headed planthopper, Epeurysa nawaii, a species with unique feeding habits on bamboo. A total of 165 salivary proteins were identified, with 114 secretory genes highly and specifically expressed in SGs. Consistent with most phloem-feeding insects, digestive enzymes, calcium-binding proteins, oxidoreductases, and a few previously reported salivary effectors were ubiquitously distributed in E. nawaii saliva. However, we also identified a substantial portion of salivary proteins exhibiting taxonomy specificity, including 60 E. nawaii-specific and 62 Delphacidae-specific proteins. These taxonomy-restricted proteins potentially play a role in insect adaptation to specific host plants. Our study provides an efficient pipeline for salivary protein identification and serves as a valuable resource for the functional characterization of effectors.
ERK pathway agonism for cancer therapy: evidence, insights, and a target discovery framework
Authors: Timofeev Oleg , Giron Philippe , Lawo Steffen , Pichler Martin , Noeparast Maxim
Published: March 2024

At least 40% of human cancers are associated with aberrant ERK pathway activity (ERKp). Inhibitors targeting various effectors within the ERKp have been developed and explored for over two decades. Conversely, a substantial body of evidence suggests that both normal human cells and, notably to a greater extent, cancer cells exhibit susceptibility to hyperactivation of ERKp. However, this vulnerability of cancer cells remains relatively unexplored. In this review, we reexamine the evidence on the selective lethality of highly elevated ERKp activity in human cancer cells of varying backgrounds. We synthesize the insights proposed for harnessing this vulnerability of ERK-associated cancers for therapeutical approaches and contextualize these insights within established pharmacological cancer-targeting models. Moreover, we compile the intriguing preclinical findings of ERK pathway agonism in diverse cancer models. Lastly, we present a conceptual framework for target discovery regarding ERKp agonism, emphasizing the utilization of mutual exclusivity among oncogenes to develop novel targeted therapies for precision oncology.
The landscape of immune checkpoint-related long non-coding RNAs core regulatory circuitry reveals implications for immunoregulation and immunotherapy responses
Authors: Qu Changfan , Cui Hao , Xiao Song , Dong Longlong , Lu Qianyi , Zhang Lei , Wang Peng , Xin Mengyu , Zhi Hui , Liu Chenyu , Ning Shangwei , Gao Yue
Published: March 2024

Long non-coding RNAs (lncRNAs) could modulate expression of immune checkpoints (ICPs) by cooperating with immunity genes in tumor immunization. However, precise functions in immunity and potential for predicting ICP inhibitors (ICI) response have been described for only a few lncRNAs. Here we present an integrated framework that leverages network-based analyses and Bayesian network inference to identify the regulated relationships including lncRNA, ICP and immunity genes as ICP-related LncRNAs mediated Core Regulatory Circuitry Triplets (ICP-LncCRCTs) that can make robust predictions. Hub ICP-related lncRNAs such as MIR155HG and ADAMTS9-AS2 were highlighted to play central roles in immune regulation. Specific ICP-related lncRNAs could distinguish cancer subtypes. Moreover, the ICP-related lncRNAs are likely to significantly correlated with immune cell infiltration, MHC, CYT. Some ICP-LncCRCTs such as CXCL10-MIR155HG-ICOS could better predict one-, three- and five-year prognosis compared to single molecule in melanoma. We also validated that some ICP-LncCRCTs could effectively predict ICI-response using three kinds of machine learning algorithms follow five independent datasets. Specially, combining ICP-LncCRCTs with the tumor mutation burden (TMB) improves the prediction of ICI-treated melanoma patients. Altogether, this study will improve our grasp of lncRNA functions and accelerating discovery of lncRNA-based biomarkers in ICI treatment.
Directly visualizing individual polyorganophosphazenes and their single-chain complexes with proteins
Authors: Hlushko Raman , Pozharski Edwin , Prabhu Vivek M. , Andrianov Alexander K.
Published: March 2024

Polyorganophosphazenes are water-soluble macromolecules with immunoadjuvant activity that self-assemble with proteins to enable biological functionality. Direct imaging by cryogenic electron microscopy uncovers the coil structure of those highly charged macromolecules. Here, we successfully visualize individual polymer chains within the vitrified state in the absence of additives for contrast enhancement which is attributed to the high mass contrast of the inorganic backbone. Upon assembly with proteins, multiple protein copies bind at the single polymer chain level resulting in structures reminiscent of compact spherical complexes or stiffened coils. The outcome depends on protein characteristics and cannot be deduced by commonly used characterization techniques, such as light scattering, thus revealing direct morphological insights crucial for understanding biological activity. Atomic force microscopy supports the morphology outcomes while advanced analytical techniques confirm protein-polymer binding. The chain visualization methodology provides tools for gaining insights into the processes of supramolecular assembly and mechanistic aspects of polymer-enabled vaccine delivery.
Synoptic and planetary-scale dynamics modulate Antarctic atmospheric river precipitation intensity
Authors: Baiman Rebecca , Winters Andrew C. , Pohl Benjamin , Favier Vincent , Wille Jonathan D. , Clem Kyle R.
Published: March 2024

Although rare, atmospheric rivers substantially influence the interannual variability of Antarctic surface mass balance. Here we use MERRA-2 reanalysis to identify characteristics unique to atmospheric river environments by comparing (1) Analog (environments that feature high-low pressure couplets, similar to Atmospheric River environments, but no Atmospheric River), (2) Atmospheric River, and (3) Top Atmospheric River (highest precipitation) timesteps during 1980–2019 around Antarctica. We find significant differences between Atmospheric River and Analog environments including more intense and poleward-shifted mid-tropospheric geopotential height couplets as well as larger atmospheric moisture anomalies. We find similar significant enhancement in synoptic-scale dynamic drivers of Top Atmospheric Rivers compared to all Atmospheric River environments, but no significant difference in local integrated water vapor anomalies. Instead, our results highlight the importance of large-scale dynamic drivers during Top Atmospheric River timesteps, including amplified Rossby waves excited by tropical convection.
System characterization of a human-sized 3D real-time magnetic particle imaging scanner for cerebral applications
Authors: Thieben Florian , Foerger Fynn , Mohn Fabian , Hackelberg Niklas , Boberg Marija , Scheel Jan-Philipp , Möddel Martin , Graeser Matthias , Knopp Tobias
Published: March 2024

Since the initial patent in 2001, the Magnetic Particle Imaging community has endeavored to develop a human-applicable Magnetic Particle Imaging scanner, incorporating contributions from various research fields. Here we present an improved head-sized Magnetic Particle Imaging scanner with low power consumption, operated by open-source software and characterize it with an emphasis on human safety. The focus is on the evaluation of the technical components and on phantom experiments for brain perfusion. We achieved 3D single- and multi-contrast imaging at 4 Hz frame rate. The system characterization includes sensitivity, resolution, perfusion and multi-contrast experiments as well as field measurements and sequence analysis. Images were acquired with a clinically approved tracer and within human peripheral nerve stimulation thresholds. This advanced scanner holds potential as a tomographic imager for diagnosing conditions such as ischemic stroke (different stages) or intracranial hemorrhage in environments lacking electromagnetic shielding, such as the intensive care unit.
Metabolic priming by multiple enzyme systems supports glycolysis, HIF1α stabilisation, and human cancer cell survival in early hypoxia
Authors: Grimm Fiona , Asuaje Agustín , Jain Aakriti , Silva dos Santos Mariana , Kleinjung Jens , Nunes Patrícia M , Gehrig Stefanie , Fets Louise , Darici Salihanur , MacRae James I , Anastasiou Dimitrios
Published: March 2024

Adaptation to chronic hypoxia occurs through changes in protein expression, which are controlled by hypoxia-inducible factor 1α (HIF1α) and are necessary for cancer cell survival. However, the mechanisms that enable cancer cells to adapt in early hypoxia, before the HIF1α-mediated transcription programme is fully established, remain poorly understood. Here we show in human breast cancer cells, that within 3 h of hypoxia exposure, glycolytic flux increases in a HIF1α-independent manner but is limited by NAD+availability. Glycolytic ATP maintenance and cell survival in early hypoxia rely on reserve lactate dehydrogenase A capacity as well as the activity of glutamate-oxoglutarate transaminase 1 (GOT1), an enzyme that fuels malate dehydrogenase 1 (MDH1)-derived NAD+. In addition, GOT1 maintains low α-ketoglutarate levels, thereby limiting prolyl hydroxylase activity to promote HIF1α stabilisation in early hypoxia and enable robust HIF1α target gene expression in later hypoxia. Our findings reveal that, in normoxia, multiple enzyme systems maintain cells in a primed state ready to support increased glycolysis and HIF1α stabilisation upon oxygen limitation, until other adaptive processes that require more time are fully established.
Ring expansion of spirocyclopropanes with stabilized sulfonium ylides: highly diastereoselective synthesis of cyclobutanes
Authors: Nambu Hisanori , Onuki Yuta , Aso Kana , Kanamori Momoka , Tomohara Keisuke , Tsuge Kiyoshi , Yakura Takayuki
Published: March 2024

A novel method was devised for regioselective ring expansion of spirocyclopropanes to spirocyclobutanes with stabilized sulfonium ylides, affording 1,2-trans-disubstituted 6,8-dioxaspiro[3.5]nonane-5,9-diones without the formation of any isomers.
Rashba and Dresselhaus effects in doped methylammonium lead halide perovskite MAPbI3
Authors: Arya Megha , Bhumla Preeti , Sheoran Sajjan , Bhattacharya Saswata
Published: March 2024

Inorganic–organic lead halide perovskites, particularly methylammonium lead halide (MAPbI3) perovskite, have been regarded as promising materials for optoelectronics and spintronics.
A multi-edge study: investigating Co oxidation states of pristine LiNixMnyCo1−x−yO2 cathode materials by high energy-resolution X-ray spectrometry
Authors: Bzheumikhova Karina , Zech Claudia , Schüler Kai , Vinson John , Kayser Yves , Beckhoff Burkhard
Published: March 2024

The investigation of Co oxidation states in pristine LiNixMnyCo1−x−yO2 (NMC) cathodes (NMC111, NMC622, NMC811) has been a subject of ongoing debate, with conflicting findings in the literature.
First-principles studies on the electronic and contact properties of monolayer Ga2STe–metal contacts
Authors: Zhang Wanyunfei , Xia Cai-Juan , Zhao Xu-Mei , Zhang Guo-Qing , Li Lian-Bi , Su Yao-Heng , Fang Qing-Long
Published: March 2024

First-principles calculations are combined with the non-equilibrium Green's function method to investigate the interfacial properties of ML Ga2STe–metal contacts.
Selective perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) adsorption by nanoscale zero-valent iron (nZVI): performance and mechanisms
Authors: Fang Junhua , Xu Kairan , Liu Airong , Xue Yinghao , Tie Luna , Deng Zilong , Qiu Rongliang , Zhang Wei-xian
Published: March 2024

This study investigated the adsorption of PFOA and PFOS by nanoscale zero-valent iron, revealing the adsorption mechanism and enriching the understanding of environmental remediation.
Engineering the substrate preference of glucose oxidase for the enzymatic oxidation of xylose
Authors: Wang Yue , Cao Xueting , Jiang Shanshan , Gao Liwei , Han Xiaolong , Qu Jingyao , Jiang Xukai , Liu Guodong , Qu Yinbo
Published: March 2024

Glucose oxidase was engineered for increased activity on d-xylose, which enabled co-oxidation of d-glucose and d-xylose to corresponding aldonolactones.
In situ aqueous phase hydrodeoxygenation of methyl palmitate on Ni–Co alloy particles embedded in mesoporous carbon hollow sphere catalysts
Authors: Feng Shangzhen , Zhou Hantao , Wang Zhongze , Shu Sihao , Zhang Xing , Chen Jixiang
Published: March 2024

Ni–Co alloy particles embedded in mesoporous carbon hollow sphere (NiCo@MCHS) catalysts promote the internal diffusion and in situ aqueous phase hydrodeoxygenation of methyl palmitate.
Research progress of Co-based spinel oxide materials for direct methanol fuel cells
Authors: Zhong Zhiyang , Zhang Qinghui , Zhu Yingying , Chen Bingyu , Xu Siyan , Shen Tianyu , Xie Aijuan , Luo Shiping
Published: March 2024

With decades of research, both the synthesis and applications of spinels have achieved greatly increased development. The preparation, regulation strategies, and their application in MOR of Co based spinels are reviewed in this paper.
Plasmonic Au nanoparticles enhance the photogenerated electron efficiency for carbon dioxide photoreduction
Authors: Dai Jiachao , Zhong Kang , She Yuanbin , Yang Jinman , Hua Yingjie , Zhu Xingwang , Xu Hui , Li Huaming
Published: March 2024

We prepared a Aux/BaTiO3 plasmonic photocatalyst where Au NPs promote the separation of photogenerated electron–hole pairs and provide hot-electron injection through the LSPR effect, thus enhancing the Aux/BaTiO3 photocatalytic reduction of CO2 performance.
Ligand-free ultrasmall palladium nanoparticle catalysis for the Mizoroki–Heck reaction in aqueous micelles
Authors: Luo Xiaojun , Wu Siyuan , Hou Linxi , Ge Xin
Published: March 2024

A simple and sustainable strategy is proposed to construct a nanoreactor by connecting micelles with in-situ prepared ultrasmall Pd NPs to efficiently catalyze the Mizoroki-Heck reaction.
Analysing the effect caused by increasing the molecular volume in M1-AChR receptor agonists and antagonists: a structural and computational study
Authors: Montejo-López Wilber , Sampieri-Cabrera Raúl , Nicolás-Vázquez María Inés , Aceves-Hernández Juan Manuel , Razo-Hernández Rodrigo Said
Published: March 2024

Two QSAR models which correlates the interaction energy and structural features of agonists and antagonists of M1-AChR.
Ion etching modulates the synthesis of CoNiCU sulfide for high-performance supercapacitors
Authors: Wu Hao , Zhu Jie , Wang Guoxiang , Min Qingwang , Ai Boyan , Liang Pengchao , Yuan Rui , Fang Dahui
Published: March 2024

The trimetallic sulfide with an octahedral hollow structure is a supercapacitor component material with excellent performance.
A Förster resonance energy transfer enabled photo-rechargeable battery with an energetically misaligned Cu-porphyrin dye/Cu:V2O5 photocathode
Authors: Naskar Souvik , Maity Debanjan , Dixit Anamika , Freitag Marina , Kumari Kusum , Singh Saurabh Kumar , Deepa Melepurath
Published: March 2024

A photo-rechargeable Zn2+ ion battery enabled by Förster resonance energy transfer from Cu:V2O5 to Cu-porphyrin dye is photocharged to 1.4 V and delivers a photo-charging capacity of 91 mA h g−1 without the application of any voltage or current.
Controlling electron transfer in a lateral near-infrared polymer photodetector by adding higher-LUMO-level acceptors: a pathway to reduce dark current
Authors: Han Tao , Li Xiaoting , Zhang Junjie , Tang Wenjun , Jiang Sirong , Pan Changle , Qian Yue , Ding Shufang , Chen Yaqi , Jiang Chunzhi
Published: March 2024

A large potential barrier is formed by introducing higher-LUMO-level acceptors into the bulk heterojunction, which ensures that the electrons recombine with holes instead of exhibiting transmission, decreasing the dark current ~3 orders of magnitude.
Tailoring quantum transport efficiency in molecular junctions via doping of graphene electrodes
Authors: Wang Xintai , Ning Shanglong , Lin Liyuan , Li Xiaoying , Ford Christopher J. B.
Published: March 2024

The efficiency of charge transport across a well-ordered molecular array is influenced not only by the molecular structure but also by the state of the electrode.
Site-selective direct nitration of 2H-indazoles: easy access to 7-nitroindazoles
Authors: Bhattacharjee Suvam , Hajra Alakananda
Published: March 2024

This work discloses a new methodology for the site-selective direct installation of a nitro group at the benzene ring of 2H-indazoles with excellent selectivity towards the synthesis of 7-nitroindazole derivatives.
Ionized water-soluble organic nanosheets with light/ultrasound dual excitation channels for efficient killing of multidrug-resistant bacteria
Authors: Gu Yufan , Jiang Dayong , Wang Luoyi , Gao Guangpeng , Jin Xu-Hui
Published: March 2024

A novel ionized heavy-atom-free two-dimensional organic nanosheet was prepared and exhibited highly selective generation of singlet oxygen under both light and ultrasound excitation.
Overdetermination method for accurate dynamic ion correlations in highly concentrated electrolytes
Authors: Pothmann Tabita , Middendorf Maleen , Gerken Christian , Nürnberg Pinchas , Schönhoff Monika , Roling Bernhard
Published: March 2024

An experimental overdetermination method and a Reverse Monte Carlo-based approach lead to strongly reduced uncertainties of transport parameters for highly concentrated electrolytes and to accurate information about ion correlations and transport limitations in batteries.
Integrated biocompatible 3D printed isoporous membranes with 7 μm pores
Authors: Viglione Matthew S. , Saxton Aubrianna , Downs Dawson , Woolley Adam T. , Christensen Kenneth A. , Van Ry Pam M. , Nordin Gregory P.
Published: March 2024

A new 3D printing method allows for fabrication of porous membranes with 7 μm pores. A device mimicking an organ-on-a-chip design is fabricated and seeded with living cells, demonstrating potential for diverse biological and mechanical applications.
Formation mechanism of anisotropic gelatin hydrogel by self-assembly on oriented templates
Authors: Kawaguchi Kohei , Maeda Tamaki , Komatsu Syuuhei , Nomura Yoshihiro , Murai Kazuki
Published: March 2024

The development of structurally controlled techniques inspired by the structural formation of living systems is of great importance for the fabrication of next-generation functional soft materials using environmentally friendly processes.
NiCo alloy synergistic Pt nanocatalysts for enhancing the durability of the methanol oxidation reaction
Authors: Luo Feng , Wen Tingyi , Wu Jiarui , Qin Hao qing , Wu Xiaoqiang
Published: March 2024

By electrodepositing Pt/NiCo nanocatalysts on l-shaped glassy carbon substrates, high methanol oxidation reaction (MOR) durability was achieved.
Tunable wavelength of fluorescence and afterglow in super-bright carbon dot-based composite materials
Authors: Cui Yulong , Sun Wenxuan , Dong Yao , Jiang Yingnan , Zhang Jie , Zhao Tong , Zhang Jing , Wang Yankai , Sun Meiling , Yin Guangchao
Published: March 2024

Adjusting the matrix to regulate the emission wavelength of the composite material. Its quantum yield can reach up to 61.22%.
Efficient elimination of Hg(ii) from water bodies with acid-modified magnetic biomass spent tea leaves: conditional optimization and application
Authors: Cheng Dingli , Li Yiwen , Zheng Xinyu , Guo Yongfu
Published: March 2024

To effectively enhance the resource utilization of biomass waste, a acid-modified magnetic biomass spent tea leaves (NiFe2O4/STLs) was prepared via the pyrolysis and co-precipitation methods and used to eliminate mercury (Hg(ii)) from water bodies.
A colorimetric and photothermal dual-mode immunobiosensor for chloramphenicol based on the β-NiOOH nanozyme-3,3′,5,5′-tetramethylbenzidine system
Authors: Lian Yuxing , Zheng Mengqin , Li Suhua , Lai Wenqiang , Tang Dianping , Lin Youxiu
Published: March 2024

A colorimetric and photothermal dual-mode detection method based on β-NiOOH nanozyme-3,3′,5,5′-tetramethylbenzidine system was established for chloramphenicol content in fruit juice.
Chitosan-adhered graphene/nano iron tetroxide carbon paper electrode for the detection of hexavalent chromium
Authors: Tian Liangyi , Huang Ting , Xiang Yilei , Bi Yichun , Yu Zihan , Xie Jihuan , Qiu Jingping , Chen Lemin , Jiang Linbin
Published: March 2024

A modified electrode for rapid determination of hexavalent chromium in solution in a three-electrode system was prepared.
Catalytic intermolecular hydrofunctionalizations of ynamides
Authors: Zhao Ying-Ying , Jia Yu-Jing , Hu Yan-Cheng
Published: March 2024

This review carefully summarizes the advances achieved in catalytic hydrofunctionalization of ynamides and is categorized by the bond formation type including C−C, C−X, C−O, C−N, C−S, C−P, C−Si, and C−Ge bonds.
Galactosyl BODIPY-based nanoparticles as a type-I photosensitizer for HepG2 cell targeted photodynamic therapy
Authors: Liu Jin-Yu , Tian Ye , Dong Lei
Published: March 2024

Herein, we report galactosyl diiodo-BODIPY-based nanoparticles as a type-I photosensitizer (PS) with high water solubility for HepG2 cell targeted photodynamic therapy.
The effects of Sr-substitution in Ba2SmTi2Nb3O15 ceramics: structural study, optical properties, and complex impedance spectroscopy
Authors: Chourti Karim. , Jalafi Ilyas. , Bendahhou Amine. , El Barkany Soufian , Abou-Salama Mohamed.
Published: March 2024

Ceramics of (Ba1−xSrx)2SmTi2Nb3O15, denoted as BSxSTN (x = 0, 0.25 and 0.5), were synthesized by the conventional solid-state reactions route.
Catalytic performance and mechanism study of the isomerization of 2,5-dichlorotoluene to 2,4-dichlorotoluene
Authors: Ma Jiang-Tao , Meng Teng-Fei , Chen Zi-Yun , Zhu Yu-Jun , Lian Cheng , Wang Peng , Liu Ding-Hua , Zhao Yu-Pei
Published: March 2024

The influence of a hydrothermally modified HZSM-5 catalyst on the isomerization of 2,5-dichlorotoluene (2,5-DCT) to 2,4-dichlorotoluene (2,4-DCT) was investigated from both experimental and simulation perspectives.
Biomass-based ionic liquids efficiently catalyzed the cycloaddition reaction of epoxides with CO2 by hydrogen-bonding and the anion cooperative effect
Authors: Guo Kaixin , Ji Na , Han Feng , Yang Qingfeng , Wang Ning , Miao Chengxia
Published: March 2024

Several novel biomass-based ionic liquids derived from 5-hydroxymethylfurfural were used as single-component, recyclable and efficient catalysts for transformation of CO2.
Defect-level trap optimization in Cu2ZnSn(S,Se)4 photovoltaic materials via Sb3+-doping for over 13% efficiency solar cells
Authors: Li Yingfen , Chen Xingye , Wang Runxi , Zhou Nian , Huang Fang , Zhao Jun , Su Zhenghua , Chen Shuo , Liang Guangxing
Published: March 2024

Defect-level trap optimization via Sb3+-doping Cu2ZnSn(S,Se)4 enables over 13% efficient thin film solar cell.
A domino reaction from a sensitive azide: the impact of positional isomerism on chemical reactivity featuring ortho azido/nitro substituted derivatives
Authors: Thaltiri Vikranth , Singh Jatinder , Staples Richard J. , Shreeve Jean'ne M.
Published: March 2024

This study highlights for the first time the impact of positional isomerism on chemical reactivity which involves a domino reaction, salt formation, cyclization, and nucleophilic substitution.
Scanning the new frontier of mental health: psychedelic brain imaging
Authors: Ertl Natalie , Wall Matthew B.
Published: March 2024

The use of psychoactive substances for ritual, spiritual and medicinal purposes stretches back into prehistory and has been a common feature of many diverse cultures and societies globally. Psychedelics, with their unique ability to amplify feelings of connectedness and openness, may have also served as tools for promoting tribal cohesion and trust in ancient cultures. Psychedelic is a broad term derived from the Greek words ‘psyche’, meaning soul or mind, and ‘deloun’, which means to manifest. Classic psychedelics, such as psilocybin (the active ingredient in magic mushrooms), act directly on the serotonin 5-HT2A receptor, while atypical psychedelics, such as MDMA and ketamine, have different pharmacological modes of action and tend to have less of a hallucinogenic effect. They all produce (as the origin of their name suggests) a profound shift in consciousness, generally positive emotional states and feelings of connectedness and openness. Lysergic acid diethylamide (LSD) is in many ways the prototypical psychedelic and began the first wave of psychedelic research in western medicine after it was first synthesized in the early 1940s. By the 1960s, thousands of patients had received LSD therapy in the USA, the UK, Czech Republic and elsewhere for depression, anxiety, addiction and a number of other disorders. This period concurrently saw the development of other key psychiatric drugs such as monoamine oxidase inhibitors as antidepressants and dopamine antagonist drugs as antipsychotics. This revolution in psychiatric treatment ushered in a wave of research and entirely new perspectives on the biological mechanisms underpinning psychiatric disorders.
Vocal Range Variations Elicited With a Standard Mandarin Reading Passage in Individuals With Voice Disorders
Authors: Chiang Yu-Ning , Chan Roger W. , Hsieh Li-Chun
Published: March 2024

Purpose:

This study examined whether the “Three Bears Passage” (TB), a standard Mandarin reading passage, could elicit significant vocal range variations in individuals with voice disorders. Relative sensitivity of TB versus another existing standard reading passage, “Passage in Mandarin” (PM), for differentiating between individuals with and without voice disorders was also evaluated.

Method:

Forty-two individuals with normal voice and 30 individuals with voice disorders participated in the study. Maximum fundamental frequency (
f
0
), minimum
f
0
, mean
f
0
,
f
0
range, maximum vocal intensity, minimum intensity, mean intensity, and intensity range of all participants reading aloud the two passages were measured with Praat to construct speech range profiles (SRPs).

Results:

Significantly larger vocal range was found for TB than for PM in individuals with voice disorders, including significantly higher maximum
f
0
, mean
f
0
, maximum intensity, mean intensity, and significantly larger
f
0
range and intensity range. Significantly more limited vocal range was observed in individuals with voice disorders than those without, with more obviously restricted SRPs while reading aloud TB compared to PM. Receiver operating characteristic analysis suggested that TB was more sensitive than PM in distinguishing between individuals with and without voice disorders.

Conclusions:

Our findings supported the potential of TB as a standard clinical assessment tool for evaluating pathological changes in vocal range. Future studies should explore if therapeutic approaches based on the passage or variations of it could be developed for overcoming functional limitations and restrictions in vocal range for specific voice disorders.
Adaptation of the Cochlear Implant Quality of Life–35 Profile Into German
Authors: Pützer Elena , McRackan Theodore R. , Lang-Roth Ruth , Schäfer Karolin
Published: March 2024

Purpose:

The adaptation of existing questionnaires is a valuable method to make instruments available in multiple languages. It is necessary to assure the quality of an adaptation by following adaptation guidelines. The Cochlear Implant Quality of Life–35 Profile (CIQOL-35 Profile) was developed and validated to measure the functional abilities in English-speaking adult CI users but is not yet available in German. In this study, we performed a cross-cultural adaptation of this instrument to make it applicable in research and rehabilitation with German-speaking patients.

Method:

This study followed established practice guidelines for translating and adapting hearing-related questionnaires. Professional translators and health care professionals with experience with patients with hearing loss translated all items forward and backward multiple times. A committee reviewed the process and decided when a satisfactory consensus was achieved. Next, we examined the intelligibility of the German version using cognitive interviews with 15 adult CI users.

Results:

For most items, there was no difficulty with direct translation. In items that turned out to be more difficult to translate, it proved to be very helpful to compare the back translation to the original version, discuss the wording in the committee, and ask the source-language questionnaire developer. During the interviews, issues of comprehension for some phrases were identified. These phrases were changed according to the participant's questions and suggestions.

Conclusions:

The CIQOL-35 Profile was successfully adapted into German. The German version of the questionnaire is now available for research and clinical practice. Further validation of the German CIQOL-35 Profile is in progress.

Supplemental Material:

https://doi.org/10.23641/asha.25386571
Learnable binary MIMO detection with negative penalty based on inexact ADMM
Authors: Kim Minwoo , Kim Minsik , Park Daeyoung
Published: March 2024

In this letter, a new learnable binary MIMO detection algorithm in massive MIMO systems with one‐bit analog‐to‐digital converters is proposed. A negative penalty is introduced to transform a non‐convex constraint to a convex box constraint and a learnable iterative algorithm is presented based on inexact alternating direction methods of multipliers. The proposed MIMO detection method performs better than the existing binary MIMO detection methods even with lower computational complexity.
Short‐term power forecasting method for 5G photovoltaic base stations on non‐sunny days based on SDN‐integrated INGO‐BP and RGAN
Authors: Huang Jinbao , Guo Wenhao , Wei Rui , Yan Ming , Hu Yongle , Qin Tuanfa
Published: March 2024

In response to the suboptimal efficiency observed in the network configuration and administration of 5G photovoltaic base stations (PVBSs), as well as the inherent limitations in accurately forecasting photovoltaic power during inclement weather conditions, this research article introduces a concise and effective method for short‐term power prediction of PVBSs when subjected to non‐sunny weather conditions, leveraging the paradigm of software defined networking. This method ingeniously amalgamates the improved Northern Goshawk optimized back propagation neural network (INGO‐BP) and recurrent generative adversarial networks (RGAN). The investigation commences by delineating a comprehensive PVBS system framework underpinned by SDN principles. Subsequently, it employs the Pearson correlation coefficient technique and principal component analysis for the judicious selection of pertinent features from the PVBS photovoltaic dataset, thereby ameliorating the issue of multicollinearity within the predictive model. To culminate the research endeavour, the INGO algorithm is enlisted to optimize the weightings and bias parameters of the BP neural network, while RGAN is harnessed for the acquisition of distinctive distribution patterns in photovoltaic data across diverse meteorological conditions. This augmentation enhances the model's capacity to discern the intricate long‐term mappings between photovoltaic power and meteorological data. The empirical findings substantiate the elevated accuracy of the INGO‐BP prediction model across sunny, cloudy, and rainy weather conditions, with a discernible enhancement in predictive accuracy for PVBS performance under non‐sunny weather conditions facilitated by data augmentation via RGAN.
Automatic constraint programming solver selection method based on machine learning for the cable tree wiring problem
Authors: Zhang Zhixin , Xiao Chenglong , Wang Shanshan , Yu Weilun , Bai Yun
Published: March 2024

Cable trees are primarily employed in industrial products to facilitate energy transfer and information exchange among various components. When utilizing machines for assembly, it is essential to convert the wiring plan into a sequence of cable insertion operations executed by the machine under various constraints. This poses a combinatorial optimization problem. In this domain, constraint programming (CP) solvers often exhibit outstanding performance by leveraging their robust problem‐modelling capabilities, excellent scalability, and precise solving capabilities. However, CP solvers may achieve various performances for different problem instances. Selecting the most suitable CP solver for each problem instance is crucial. This paper introduces an automatic selection algorithm for CP solvers to solve the cable tree wiring problem (CTW). Firstly, a scoring system is used to conduct an in‐depth analysis and compare four well‐known CP solvers: CPLEX, Chuffed, OR‐Tools, and Gurobi. The results indicate that OR‐Tools and CPLEX outperform other solvers in performance. Moreover, these two solvers exhibit complementary advantages in quickly finding optimal and feasible solutions within specified time limits. Therefore, CP and machine learning are ingeniously integrated, harnessing their complementary advantages. 4240 instances covering various scenarios are randomly generated to form the problem space. This method incorporates decision trees, random forests, K‐nearest neighbours, and naive Bayes, utilizing these four machine learning techniques. The proposed method can achieve better results than traditional single CP solvers. Among all the evaluated machining learning techniques, the automatic solver selection methods based on decision trees and random forests can achieve accuracy rates of 91.29% and 84.15%, respectively.
Leitlinien: Wie entstehen sie? Was sind ihre Möglichkeiten und
Grenzen?
Authors: Elsner Bernhard , Mehrholz Jan
Published: March 2024

Vor knapp 30 Jahren begann eine Expertenkommission mit der Sammlung von
diagnostischen und therapeutischen Empfehlungen anhand eines transparenten
Regelwerks. Neben der Konsensbildung in Diagnostik und Therapie dienen
Leitlinien der Qualitätssicherung. Inzwischen sind sie fest im deutschen
Gesundheitssystem verankert.
Kompressionstherapie bei entzündlichen Dermatosen – Psoriasis vulgaris und Varikose
Authors: Assaf Katharina , Schäfer Jana
Published: March 2024

Die Varikose, das Krampfaderleiden, stellt ein häufiges Krankheitsbild dar. Die Kompressionstherapie kommt hier standardmäßig zur Anwendung. Bei der Psoriasis vulgaris, einer chronisch-entzündlichen Hauterkrankung, können lokale Reize das Auftreten typischer Hautläsionen triggern. Ein örtlicher Zusammenhang psoriatischer Plaques und Varizen wird klinisch beobachtet. Im dargestellten Fall verhalf eine ergänzende Kompression zur Abheilung.
Häufiger als gedacht – ein Update zu Dysphagie bei Multipler
Sklerose
Authors: Eckardt Carolin , Ulrike Vay Sabine , Warnke Clemens , Flossdorf Pia , Weinert Melanie
Published: March 2024

In Deutschland sind schätzungsweise mehr als 280 000 Menschen an Multipler
Sklerose (MS) erkrankt. Neben sensiblen, motorischen, vegetativen und
neuropsychologischen Funktionsstörungen ist die Dysphagie ein hochrelevantes,
stark beeinträchtigendes und zugleich bislang nicht gut untersuchtes Symptom der
Erkrankung. Der Artikel bietet eine Übersicht über die aktuelle Studienlage zur
Dysphagie bei MS und soll die Wahrnehmung für das Symptom Schluckstörung im
Kontext der MS-Erkrankung schärfen. Techniken zur weiterführenden Diagnostik und
Therapie werden vorgestellt mit dem langfristigen Ziel, betroffene Menschen mit
MS künftig zuverlässiger zu diagnostizieren, ihnen optimierte Hilfe zu bieten
und ihre Lebensqualität zu verbessern.
Dermatovenerologie in Innsbruck
Authors: Eckmann Sonja , André Fiona , Böckle Barbara , Blunder Stefan , Dubrac Sandrine , Frischhut Nina , Gattringer Cornelia , Gisinger Martin , Gruber Robert , Höllweger Nicole , Holzmann Undine , Kuen Marlene , Moosbrugger-Martinz Verena , Nguyen Van Anh , Ratzinger Gudrun , Reider Norbert , Romani Nikolaus , Sarcletti Mario , Seidl-Philipp Magdalena , Steger Seila , Ortner-Tobider Daniela , Tollinger Susanne , Tripp Christoph , Weinlich Georg , Stoitzner Patrizia , Fritsch Peter , Schmuth Matthias
Published: March 2024

Die Innsbrucker Universitäts-Hautklinik wurde 1873 als Extraordinariat gegründet. 1886 wurde sie zum zweiten Ordinariat des Faches im deutschsprachigen Raum (nach Wien 1869). Heute, 150 Jahre später, bietet die Klinik in ihrer Versorgungsregion in Westösterreich und durch ihr geografisches Naheverhältnis zum Norden Italiens, dem Osten der Schweiz und dem Süden Deutschlands ein breit gefächertes, von translationaler Forschung geprägtes, dermatovenerologisches Leistungsspektrum an und ist zentrales universitäres Ausbildungszentrum. Entsprechend wird eine enge Bindung mit den zuweisenden Ärzt*innen der Region gepflegt, die sich in niederschwelligen Zuweisungsmodalitäten und zahlreichen Fortbildungsaktivitäten niederschlägt. Auf diese Weise können den Patient*innen die neuesten Errungenschaften des Faches und der Medizin angeboten werden.
Moulagen – In Wachs gegossene Krankheiten
Authors: Lechner Christian , Lechner Miriam , Lang Johanna
Published: March 2024

Die Verwendung von Wachs in der medizinischen Forschung und Lehre blickt bereits auf eine Jahrhunderte alte Tradition zurück. In manchen Disziplinen, wie etwa der Dermatologie, ermöglichten Wachsobjekte eine deutliche Verbesserung der Ausbildung sowohl von Studierenden als auch angehenden Dermatolog*innen. Von solchen sog. Moulagen besitzt die Universitätsklinik für Dermatologie, Venerologie und Allergologie der Medizinischen Universität Innsbruck noch 65 Moulagen, befestigt an 58 Brettern, welche allesamt von dem in Wien tätigen Moulageur Karl Henning (1860–1917) zwischen 1894 und 1912 hergestellt wurden.

Rezent wurde die Notwendigkeit einer Konservierung und Restaurierung professionell erhoben und anschließend auch erfolgreich durchgeführt. Der vorliegende Beitrag gibt einen Einblick in die Entwicklungsgeschichte der Moulagen und geht anschließend konkret auf die Moulagen der Universitätsklinik für Dermatologie, Venerologie und Allergologie Innsbruck sowie deren Konservierung und Restaurierung ein.
S3-Leitlinie „Rehabilitative Therapie bei Armparese nach
Schlaganfall“ der DGNR
Authors: Platz Thomas , Mehrholz Jan
Published: March 2024

Die S3-Leitlinie „Rehabilitative Therapie bei Armparese nach Schlaganfall“ vom
23.04.2020 (gültig bis 22.04.2025) beschreibt die Effekte der rehabilitativen
Therapie bei Patienten mit einem Schlaganfall und einer Armparese.
Leitlinie „Neurogene Dysphagie“
Authors: Noppenberger Irene , Bohe Sarah
Published: March 2024

Die S1-Leitlinie „Neurogene Dysphagie“ der Deutschen Gesellschaft für Neurologie
in Zusammenarbeit mit der Deutschen Gesellschaft für Dysphagie, zuletzt
überarbeitet im Februar 2020, gibt aktuelle Empfehlungen zur Diagnostik und
Therapie von Dysphagien verschiedenster Ursachen.
Experimentelles Umfeld in der Radiologie: nachhaltig Forschen
Authors: Kiessling Fabian
Published: March 2024

Forschung erfordert hohe Geldsummen, die indirekt von den Steuerzahlern bereitgestellt werden. Daher ist es wichtig, dass diese nachhaltig ist und nicht nur der Karriereentwicklung einzelner Personen dient. Ziel dieses Artikels ist es zu erörtern, was nachhaltige Forschung in der Radiologie ist, wie diese gestaltet werden kann und vor allem aufzuzeigen, dass diese möglich ist.

Es gibt verschiedene Ansätze, Nachhaltigkeit zu erreichen, die von reinem Erkenntnisgewinn, über translatierte Geräte und Kontrastmittel bis zu neuen klinischen Anwendungen reichen. Im ersten Schritt sollte man sich genau klar werden, was man mit der Forschung erreichen will und hierbei den Neuheitswert und den zu erwartenden Impact kritisch abwägen. Nachfolgend bedarf es einer sorgfältigen, langfristigen Planung des Vorhabens über oft 5–15 Jahre mit Definition klarer Teilschritte. Eine Sicherstellung der Finanzierung ist hierbei genauso wichtig, wie eine regelmäßige Kommunikation der Ergebnisse. Oftmals ist es hierbei sinnvoll frühzeitig die Zulassungsstellen und Verwertungspartner in das Vorhaben zu involvieren.

Die akademische Radiologie sollte sich nicht darauf beschränken, als Testplattform für Bildgebungsgeräte und Kontrastmittel aus der Industrie zu dienen, sondern versuchen, eigene Ideen und Entwicklungen zu verwirklichen. Viele akademische Standorte weltweit haben gezeigt, dass dies möglich ist. Beispiele aus meiner eigenen Forschung, insbesondere bezüglich der Entwicklung und Translation der Superresolution-Ultraschallbildgebung und der Entwicklung von Diagnostika und Nanopharmazeutika werden in diesem Artikel erläutert und Herausforderungen in verschiedenen Entwicklungsschritten diskutiert. Junge Radiologen werden ermutigt, sich größere und langfristigere Ziele zu setzen, um so unser Feld nachhaltig zu beeinflussen und weiterzuentwickeln.
A Rare Presentation of Occipital Dermoid Cyst with Intracranial Extension and Secondary Infection: Case Report and Follow-Up
Authors: Li Guyu , Kim Jaechoon , Garcia Matthew , Reyes-McChesney Ivy , Hanna Ashley , Bhalala Utpal
Published: March 2024

Craniofacial dermoid cysts are congenital anomalies that rarely have intracranial extension and can be associated with other anomalies. Common sites of these lesions are the lateral brow and parietal scalp. Presentation of the dermoid cyst in the occipital region with intracranial extension is extremely rare. We report a 2-year-old female with a presentation of an occipital dermoid cyst with intracranial extension and secondary cerebellar abscess. This case highlights the rarity of the presentation of an occipital dermoid cyst with intracranial extension and secondary infection and the importance of early imaging for suspected dermoid cysts in the occipital region for identification of intracranial extension.
Turf Toe Injury: A Pictorial Review and a Didactic Case Report
Authors: Claikens Tom , Rezaie Wahid , Simons Philip
Published: March 2024

Hyperextension of the first metatarsophalangeal joint can lead to a turf toe injury of the plantar plate complex, resulting in significant morbidity for athletes. This article reviews the anatomy, pathophysiology, classification, and imaging findings of turf toe injuries. In turf toe trauma, many different structures can be injured, with the sesamoid-phalangeal ligaments the most common. Diagnosis, classification, and treatment options rely on clinical evaluation and specific magnetic resonance imaging findings. It is vital for radiologists to understand the anatomy, pathophysiology, and imaging findings of turf toe injuries to ensure an accurate diagnosis and appropriate management.
Immunoembolization for the Treatment of Uveal Melanoma Hepatic Metastases
Authors: Gonsalves Carin F.
Published: March 2024

Uveal melanoma is the most common primary intraocular tumor in adults. Approximately 50% of patients develop metastatic disease despite successful treatment of the primary eye tumor. The liver is the most common site of metastatic disease occurring in more than 90% of patients. Clinical prognosis is dependent on the ability to control the growth of liver tumors. Locoregional therapies play an important role in stabilizing liver metastases, prolonging survival for patients with metastatic uveal melanoma. As overall survival is prolonged, the development of extrahepatic disease becomes more common. Immunoembolization, a form of liver-directed therapy, not only focuses on treating hepatic metastases by stimulating the local immune system to suppress the growth of liver tumors, but it potentially generates a systemic immune response delaying the growth of extrahepatic metastases as well. The following article discusses immunoembolization for the treatment of metastatic uveal melanoma including the rationale, mechanism of action, indications, contraindications, outcomes, and associated toxicities.
The Future of Artificial Intelligence in Sports Medicine and Return to Play
Authors: Desai Vishal
Published: March 2024

Artificial intelligence (AI) has shown tremendous growth over the last decade, with the more recent development of clinical applications in health care. The ability of AI to synthesize large amounts of complex data automatically allows health care providers to access previously unavailable metrics and thus enhance and personalize patient care. These innovations include AI-assisted diagnostic tools, prediction models for each treatment pathway, and various tools for workflow optimization. The extension of AI into sports medicine is still early, but numerous AI-driven algorithms, devices, and research initiatives have delved into predicting and preventing athlete injury, aiding in injury assessment, optimizing recovery plans, monitoring rehabilitation progress, and predicting return to play.
Reinjury Following Return to Play
Authors: Watts V George J. , Tai Ryan , Joshi Ganesh , Garwood Elisabeth , Saha Debajyoti
Published: March 2024

Radiologists are frequently called on for guidance regarding return to play (RTP) for athletes and active individuals after sustaining a musculoskeletal injury. Avoidance of reinjury is of particular importance throughout the rehabilitative process and following resumption of competitive activity. Understanding reinjury risk estimation, imaging patterns, and correlation of clinical and surgical findings will help prepare the radiologist to identify reinjuries correctly on diagnostic imaging studies and optimize management for a safe RTP.
Return to Play in the Professional Athlete
Authors: Gulati Aishwarya , Desai Vishal
Published: March 2024

The management of any injury in elite athletes poses unique challenges distinct from the general population because the goal is rapid recovery and return to play (RTP) while simultaneously managing residual symptoms and minimizing risk of reinjury. The time required for treatment, recovery, and return to peak performance can have consequences for both the athlete and his or her team: financial implications, psychological stressors, team dynamics, and future performance. RTP after an injury in the professional athlete requires a complex decision-making process with many stakeholders. Several factors influence this decision, not the least of which is the type and mechanism of injury. This article provides an overview of the RTP process including nonmedical factors that may influence this decision, common injuries seen in professional athletes, injury patterns particular to certain popular sports, and imaging guidelines for such injuries.