bluuebunny/crossref_metadata_2025 huggingface dataset:
Genome-Wide Analysis of microRNA and mRNA Expression in Colorectal Intramucosal Neoplasia and Colorectal Cancer With a Microsatellite-Stable Phenotype Based on Adenoma-Carcinoma Sequences
Authors: Sugai Tamotsu , Osakabe Mitsumasa , Niinuma Takeshi , Sugimoto Ryo , Eizuka Makoto , Tanaka Yoshihito , Yanagawa Naoki , Otsuka Koki , Sasaki Akira , Matsumoto Takayuki , Suzuki Hiromu
Published: July 2022

Background

Although MicroRNAs (miRNAs) play important roles in various biological processes, the biological functions of miRNAs are achieved through mRNAs. The aim of this study is to identify dysregulated miRNA/mRNA expression patterns in colorectal tumors.

Methods

We examined 42 colorectal tumors [15 adenomas, 8 intramucosal cancers (IMCs), and 19 invasive colorectal cancers (CRCs)] with the microsatellite stable (MSS) phenotype (first cohort). The first cohort was used for genome-wide miRNA and mRNA expression arrays, whereas the second cohort (37 colorectal neoplasias) was used for validation analyses. Finally, we used 15 cases of “adenoma in/with carcinoma” to identify network patterns of miRNAs/mRNAs that were directly associated with neoplastic progression. In addition, simple regression analysis for array-based and RT-PCR analyses was performed to select candidate miRNA–mRNA pairs. Transfection of miRNA mimics was also performed to confirm whether target mRNA expression is affected by specific miRNAs.

Results

Specific paired miRNA/mRNA networks, including hsa-miR-34a-5p/SLC12A2, hsa-miR-15b-5p/SLC12A2, hsa-miR-195-5p/SLC12A2, hsa-miRNA-502-3p/OLFM4, hsa-miRNA-6807-5p/ZG16, and hsa-miRNA 3064-5p/SH3BGRL3, were identified in samples of adenoma, IMC, and CRC with the MSS phenotype. In adenomatous lesions obtained from the same tumor with a carcinomatous lesion, we identified pairs of miRNA-130a-3p/HSPA8 and miRNA-22-3p/RP53 that were linked to multiple pathways. On the other hand, 2 pairs of miRNA/mRNA (miRNA-660-5p and miRNA-664a-5p/APP) were found in isolated carcinomatous glands. Ectopic expression of miRNA 3064-5p suppressed SH3BGRL3 expression.

Conclusions

We found that networks based on specific pairs of miRNAs/mRNAs contribute to progression from adenomatous and carcinomatous lesions. Our results provide insights into the molecular tumorigenesis of colorectal tumors.
Characterization of the Immune Cell Infiltration Landscape in Esophageal Squamous Cell Carcinoma
Authors: Sui Zhilin , Wu Xianxian , Du Longde , Wang Han , Yuan Lijuan , Zhang Jian V. , Yu Zhentao
Published: July 2022

Background

Immunotherapy has achieved remarkable efficacy in treating oesophageal squamous cell carcinoma (ESCC). However, this treatment has limited efficacy in some patients. An increasing number of evidence suggested that immune cells within the tumour microenvironment (TME) are strongly related to immunotherapy response and patient prognosis. Thus, the landscape of immune cell infiltration (ICI) in ESCC needs to be mapped.

Methods

In the study, the ICI pattern in 206 cases of ESCC was characterised by two algorithms, namely, CIBERSORT and single-sample gene set enrichment analysis (ssGSEA). The ICI score of each specimen was calculated by principal component analysis (PCA) according to ICI signature genes A (ICISGA) and B (ICISGB). The prognostic difference was evaluated by using the Kaplan–Meier method. The related pathways of ICI score were investigated by applying gene set enrichment analysis (GSEA). The R packages of ‘regplot’, ‘timeROC’ and ‘rms’ were applied for the construction of nomogram model.

Result

Three TME subtypes were identified with no prognostic implication. A total of 333 differentially expressed genes (DEGs) among immune subtypes were determined, among which ICISGA and ICISGB were identified. Finally, ICI scores were constructed, and the patients were grouped into high or low ICI score group. Compared with the low ICI score group, the high ICI score group had better prognosis. GSEA revealed that the high ICI score group referred to multiple signalling pathways, including B cell receptor, Fc gamma R-mediated phagocytosis, NOD-like receptor and TGF-β signalling pathways. In addition, the nomogram model was constructed to evaluate 1-, 3- and 5-year probability of death in an ESCC patient. The ROC and calibration curves indicated that the model has a good discrimination ability.

Conclusion

We depicted a comprehensive ICI landscape in ESCC. ICI score may be used as a predictor of survival rate, which may be helpful for guiding immunotherapy in the future.
A New Nomogram and Risk Stratification of Brain Metastasis by Clinical and Inflammatory Parameters in Stage III Small Cell Lung Cancer Without Prophylactic Cranial Irradiation
Authors: Qiu Jianjian , Ke Dongmei , Yu Yilin , Lin Hancui , Zheng Qunhao , Li Hui , Zheng Hongying , Liu Lingyun , Wang Zhiping , Wu Yahua , Liu Tianxiu , Li Jiancheng
Published: July 2022

Background

This study was conducted to determine risk factors for developing brain metastasis (BM) and to predict brain metastasis free survival (BMFS) and overall survival (OS) by combining several clinical parameters and inflammatory indexes.

Materials and Methods

A nomogram and risk stratification were developed based on multivariate analysis results. The prognostic index (PI) predicting the high risk of BM was calculated by multiplying the weighted factor (β coefficient) with each variable.

Results

Thirty-two of one hundred patients (32.0%) developed BM. Multivariate cox regression analysis revealed that concurrent chemoradiotherapy (CCRT; hazard ratio (HR), 3.356; p = 0.020), monocyte–lymphocyte ratio (MLR; HR, 4.511; p = 0.002), neutrophil–lymphocyte ratio (NLR; HR, 4.023; p = 0.033), and prognostic-nutrition index (PNI; HR, 2.902; p = 0.018) were independent prognostic factors of BMFS. The nomogram has good accuracy in predicting BMFS, and the C-index was 0.73. The ROC curve showed that these risk factors have good discriminant ability. Similarly, tumor location (HR, 1.675; p = 0.035) and MLR (HR, 2.076; p = 0.013) were independent prognostic factors of OS. In the subgroup analysis of OS, the good group had a better prognosis than the other groups. Risk stratification by PI: the high-risk group had worse BMFS than the low-risk group, which also has certain practical significance for clinical practice in OS.

Conclusion

We developed a nomogram and corresponding risk stratification in stage III SCLC patients who developed BM. This model and risk stratification can help clinicians improve patient treatment management and better deliver personalized therapy.
Stereotactic Body Radiotherapy: Hitting Harder, Faster, and Smarter in High-Risk Prostate Cancer
Authors: Correa Rohann J. M. , Loblaw Andrew
Published: July 2022

Stereotactic body radiotherapy (SBRT) is a technologically sophisticated form of radiotherapy that holds significant potential to effectively treat high-risk prostate cancer (HRPC). Prostate SBRT has been the subject of intense investigation in the context of low- and intermediate-risk disease, but less so for HRPC. However, emerging data are demonstrating its potential to safely and efficiently delivery curative doses of radiotherapy, both to the prostate and elective lymph nodes. SBRT theoretically hits harder through radiobiological dose escalation facilitated by ultra-hypofractionation (UHRT), faster with only five treatment fractions, and smarter by using targeted, focal dose escalation to maximally ablate the dominant intraprostatic lesion (while maximally protecting normal tissues). To achieve this, advanced imaging modalities like magnetic resonance imaging and prostate specific membrane antigen positron emmission tomography (PSMA-PET) are leveraged in combination with cutting-edge radiotherapy planning and delivery technology. In this focused narrative review, we discuss key evidence and upcoming clinical trials evaluating SBRT for HRPC with a focus on dose escalation, elective nodal irradiation, and focal boost.
Pan-Soft Tissue Sarcoma Analysis of the Incidence, Survival, and Metastasis: A Population-Based Study Focusing on Distant Metastasis and Lymph Node Metastasis
Authors: Liu Haotian , Zhang Hongliang , Zhang Chao , Liao Zhichao , Li Ting , Yang Tielong , Zhang Gengpu , Yang Jilong
Published: July 2022

Background

The rarity and complexity of soft tissue sarcoma (STS) make it a challenge to determine the incidence, survival, and metastasis rates. In addition, the clinicopathological risk factors for lymph node metastasis have rarely been reported.

Methods

Data on patients diagnosed with STS in the SEER database from 2000 to 2018 were extracted by SEER*Stat 8.3.9.1, and the incidence trend was calculated by Joinpoint 4.9 software. The KM method was used to calculate the survival curve, and the log-rank method was used to compare differences in the survival curves. The clinicopathological risk factors for lymph node metastasis were screened by logistic regression.

Results

Among the 35987 patients, 4299 patients (11.9%) had distant metastasis. The overall lymph node metastasis rate was 6.02%, which included patients suffering from both lymph node and distant metastasis. Considering that some lymph node metastases might be accompanying events of distant metastasis, the rate of only lymph node metastasis in STS patients decreased to 3.42% after excluding patients with distant metastasis. Patients with only lymph node metastases (N1/2M0) had a significantly worse prognosis than those without metastases (N0M0) but a better prognosis than those with only distant metastases (N0M1) (p<0.0001). In the multivariate logistic analysis, STS patients with larger tumors located in the head and neck, viscera, retroperitoneum, and certain specific pathological subtypes (compared with the liposarcoma), such as undifferentiated pleomorphic sarcoma, rhabdomyosarcoma, endometrial stromal sarcoma, gastrointestinal stromal tumor, synovial sarcoma, and angiosarcoma, had a higher risk of lymph node metastasis.

Conclusions

Lymph node metastasis is rare in STS, and the metastasis rate is significantly different among the different pathological types. Tumor size, location, and pathological subtype are significantly associated with the risk of lymph node metastasis. The overall survival of patients with lymph node metastasis is better than that of patients with distant metastasis, which suggests a more precise prognosis evaluation should be performed in these AJCC stage IV STS patients.
Constraint-Based Reconstruction and Analyses of Metabolic Models: Open-Source Python Tools and Applications to Cancer
Authors: Ng Rachel H. , Lee Jihoon W. , Baloni Priyanka , Diener Christian , Heath James R. , Su Yapeng
Published: July 2022

The influence of metabolism on signaling, epigenetic markers, and transcription is highly complex yet important for understanding cancer physiology. Despite the development of high-resolution multi-omics technologies, it is difficult to infer metabolic activity from these indirect measurements. Fortunately, genome-scale metabolic models and constraint-based modeling provide a systems biology framework to investigate the metabolic states and define the genotype-phenotype associations by integrations of multi-omics data. Constraint-Based Reconstruction and Analysis (COBRA) methods are used to build and simulate metabolic networks using mathematical representations of biochemical reactions, gene-protein reaction associations, and physiological and biochemical constraints. These methods have led to advancements in metabolic reconstruction, network analysis, perturbation studies as well as prediction of metabolic state. Most computational tools for performing these analyses are written for MATLAB, a proprietary software. In order to increase accessibility and handle more complex datasets and models, community efforts have started to develop similar open-source tools in Python. To date there is a comprehensive set of tools in Python to perform various flux analyses and visualizations; however, there are still missing algorithms in some key areas. This review summarizes the availability of Python software for several components of COBRA methods and their applications in cancer metabolism. These tools are evolving rapidly and should offer a readily accessible, versatile way to model the intricacies of cancer metabolism for identifying cancer-specific metabolic features that constitute potential drug targets.
Renal Abscess Caused by Crizotinib: A Rare Case Report
Authors: Wan Zhaojun , Wang Kai , Yin Xiangfu , Guo Xiangting , Cheng Guoli , Pan Jihong
Published: July 2022

Crizotinib is a tyrosine kinase inhibitor that has been found to be effective in the treatment of c-ros oncogene 1-positive non-small cell lung cancer. Although this targeted agent for treating cancer has shown superiority to standard chemotherapy in some ways, this drug has adverse effects, such as the development of renal abscesses. Some associated renal damage may disappear with crizotinib withdrawal. Hence, we present the case of a 58-year-old man with non-small cell lung cancer on crizotinib therapy who developed bilateral renal abnormal space-occupying lesions, successively which were difficult to identify using various imaging methods; even PET-CT highly suspected the right renal masses as malignant. Finally, the right renal lesions were confirmed as renal abscesses by postoperative pathology. The left renal lesion was considered as renal cysts through the lesion disappearing after crizotinib withdrawal. There have been very few reports in this respect, especially proved by various methods and confirmed by postoperative pathology. It is important to recognize this drug-related complication in order to avoid incorrect diagnosis and inadequate therapy. It is necessary to monitor renal changes after taking crizotinib.
Central Nervous System Myeloma and Unusual Extramedullary Localizations: Real Life Practical Guidance
Authors: Sammartano Vincenzo , Cerase Alfonso , Venanzi Valentina , Mazzei Maria Antonietta , Vangone Beatrice Esposito , Gentili Francesco , Chiarotti Ivano , Bocchia Monica , Gozzetti Alessandro
Published: July 2022

Central nervous system localization of multiple myeloma (CNS-MM) accounts for about 1% of all MM during disease course or even rarer at diagnosis. A difference in the origin, i.e., osteodural or primary dural vs leptomeningeal/intraparenchymal, seems to define two distinct types of intracranial myeloma, with different clinical behavior. CNS-MM may occur also as a presentation of MM. Treatment is still unsatisfactory and many treatments have been reported: chemotherapy, intrathecal therapy, and radiotherapy, with dismal prognosis. Other sites of myeloma localization could be also of interest and deserve description. Because of the rarity and aggressiveness of the disease clinicians are often doubtful on how to treat it since there is no general agreement. Moreover, recent drugs such as the anti CD38 monoclonal antibody, immunomodulatory drugs, and proteasome inhibitors have changed the treatment of patients with MM with a significant improvement in overall response and survival. The role of novel agents in CNS MM management and unusual presentations will be discussed as well as the potential role of other new immunomodulatory drugs and proteasome inhibitors that seem to cross the blood-brain barrier. The purpose of this review is to increase awareness of the clinical unusual presentation and neuroradiological findings, give practical diagnostic advice and treatment options algorithm.
The Emerging Roles of Rad51 in Cancer and Its Potential as a Therapeutic Target
Authors: Wang Ziyi , Jia Renxiang , Wang Linlin , Yang Qiwei , Hu Xiaohai , Fu Qiang , Zhang Xinyu , Li Wenya , Ren Yi
Published: July 2022

Defects in DNA repair pathways are emerging hallmarks of cancer. Accurate DNA repairs and replications are essential for genomic stability. Cancer cells require residual DNA repair capabilities to repair the damage from replication stress and genotoxic anti-tumor agents. Defective DNA repair also promotes the accumulation of genomic changes that eventually lead to tumorigenesis, tumor progression, and therapeutic resistance to DNA-damaging anti-tumor agents. Rad51 recombinase is a critical effector of homologous recombination, which is an essential DNA repair mechanism for double-strand breaks. Rad51 has been found to be upregulated in many malignant solid tumors, and is correlated with poor prognosis. In multiple tumor types, Rad51 is critical for tumor metabolism, metastasis and drug resistance. Herein, we initially introduced the structure, expression pattern of Rad51 and key Rad51 mediators involved in homologous recombination. Additionally, we primarily discussed the role of Rad51 in tumor metabolism, metastasis, resistance to chemotherapeutic agents and poly-ADP ribose polymerase inhibitors.
Characteristics, Treatment Complexity, and Outcome of Mixed-Phenotype Acute Leukemia in Children in a Low–Middle-Income Country
Authors: Salama Maram , Ahmed Sonia , Soliman Sonya , El-Sharkawy Nahla , Salem Sherine , El-Nashar Amr , Khedr Reham , Lehmann Leslie , Sidhom Iman , El-Haddad Alaa
Published: July 2022

Background

Mixed-phenotype acute leukemia (MPAL) in children is an uncommon subtype of acute leukemia that cannot be definitively assigned to a specific lineage. There is no consensus on the best approach to therapy. Management is more complex in low–middle-income countries (LMICs).

Aim

To evaluate the clinicopathological characteristics and outcomes of patients with MPAL in a developing country.

Patients and Methods

A retrospective descriptive study of 42 pediatric patients newly diagnosed with MPAL from July 2007 until December 2017.

Results

The immunophenotyping was T/Myeloid in 24 patients (57.1%) and B/Myeloid in 16 (38.1%). Three subjects had MLL gene rearrangement, two had Philadelphia-positive chromosomes, and eight had FMS-like tyrosine kinase 3 (FLT3-ITD) internal tandem duplication (FLT3-ITD) with a ratio >0.4. Two subjects died before starting chemotherapy. Ten patients (25%) received acute lymphoblastic leukemia (ALL) induction, and all achieved complete remission (CR) with no induction deaths and no shift of therapy. Thirty patients (75%) started therapy with acute myeloid leukemia (AML) induction: five (16.6%) died during induction, 17 (56.7%) achieved CR, and 10 patients received maintenance ALL therapy after ending AML treatment. Four of the eight patients with induction failure were switched to ALL therapy. The 5-year event-free survival (EFS) and overall survival (OS) rates were 56.7% [standard error (SE): 8.1%] and 61% (SE: 8%), while the cumulative incidence of relapse was 21.7% (SE: 6.7%), with a median follow-up duration of 5.8 years. Patients treated with ALL-directed therapy had a 5-year EFS rate of 111 70% (SE: 14%) and OS rate of 78.8% (SE: 13%). Patients treated with ALL-directed therapy had a 5-year EFS rate of 70% (SE: 14.5%) and OS rate of 78.8% (SE: 13%). FLT3-ITD mutation showed a significantly lower 5-year EFS rate of 28.6% (SE: 17%) vs. 75% (SE: 9%) for the wild type, p = 0.032. Undernourished patients with a body mass index (BMI) z-score ≤-2 at presentation had a significantly lower 5-year EFS rate of 20% (SE: 17%) compared to 61.8% (SE: 8%) for patients with BMI z-score >-2, p = 0.015.

Conclusion

This study supports ALL-directed therapy for pediatric MPAL in a setting of LMIC. Given the poor outcome of FLT3-ITD, the role of FLT3 inhibitor needs to be explored in this subset of cases.
Risk Factors for Anaplastic Thyroid Carcinoma: A Case Series From a Tertiary Referral Center for Thyroid Surgery and Literature Analysis
Authors: Graceffa Giuseppa , Salamone Giuseppe , Contino Silvia , Saputo Federica , Corigliano Alessandro , Melfa Giuseppina , Proclamà Maria Pia , Richiusa Pierina , Mazzola Sergio , Tutino Roberta , Orlando Giuseppina , Scerrino Gregorio
Published: July 2022

Anaplastic thyroid carcinoma (ATC) is a very rare and extremely aggressive disease with a very poor prognosis. Several risk factors have been hypothesized, but there is no clear-cut literature data on it. We reviewed the literature concerning risk factors for ATC and analyzed the institutional database from 2005 to 2022. In total, 15 papers were suitable for review, while the retrospective data collection search, conducted on our institutional database, provided 13 results. In our experience, in agreement with literature data, ATC seems to be a neoplasm peculiar to old age (in our database, mean age is 72 years), with a higher prevalence in subjects with a low level of education and a long history of multinodular goiter (MNG). The role of cigarette smoking and blood group, hypothesized on some literature data, was more uncertain, although the small sample size evaluated probably had a great influence on these results. The higher incidence of the disease in individuals with a history of MNG could suggest more aggressive choices in the treatment of a benign disease, in contrast to current practice. However, this may be a highly questionable point considering that ATC accounts for no more than 2% of all thyroid neoplasms in surgical departments, even those dedicated to endocrine neck surgery. Further studies are therefore necessary for a step forward in this direction.
Update of Key Clinical, Histological and Molecular Features of Malignant Bone Tumours Arising in the Craniofacial Skeleton
Authors: Haefliger Simon , Andrei Vanghelita , Baumhoer Daniel
Published: July 2022

The craniofacial skeleton is a highly complex and specialized anatomic region containing and protecting the brain and sensory organs. Bone sarcomas arising here comprise a heterogeneous group of tumours, some of which differ in their biological behaviour compared to their peripheral counterparts. The reasons for this seem to lie, at least partially, in the embryonal development of the craniofacial bones. For reaching the correct diagnosis as the cornerstone of optimal personalised treatment planning, a multidisciplinary team of specialists, including pathologists, radiologists, oncologists, and head and neck surgeons needs to be involved. The most common tumours arising in the craniofacial bones are bone-forming tumours, cartilage-forming tumours, fibro-osseous lesions, giant cell-rich lesions, and notochordal tumours. While morphology remains the backbone for the diagnosis, the last decade has witnessed tremendous advances in the molecular characterization of tumours, and molecular testing is increasingly becoming a part of the diagnostic process. The integration of these new molecular markers into the diagnostic approach has undoubtedly increased the diagnostic accuracy and objectivity, and holds great promise to also identify new therapeutic targets for precision medicine in the future. Examples include HEY1-NCOA2 in mesenchymal chondrosarcoma, IDH1/2 mutations in chondrosarcoma and TFCP2 rearrangements in rhabdomyosarcoma. In this article, key clinical, histological and molecular features of malignant bone tumours arising in the craniofacial region are discussed, with a special focus on the differential diagnosis and prognostic considerations.
Luteolin Binds Streptolysin O Toxin and Inhibits Its Hemolytic Effects and Cytotoxicity
Authors: Guo Tingting , Liu Peng , Wang Zeyu , Zheng Yuling , Huang Wenhua , Kong Decong , Ding Lizhong , Lv Qingyu , Wang Zhongtian , Jiang Hua , Jiang Yongqiang , Sun Liping
Published: July 2022

Group A streptococcus (GAS, Streptococcus pyogenes) is a common pathogen that can cause a variety of human diseases. Streptolysin O (SLO) is an exotoxin produced by GAS. It is a pore-forming toxin (PFT) that exhibits high in vivo toxicity. SLO enables GAS to evade phagocytosis and clearance by neutrophils, induces eukaryotic cell lysis, and activates inflammatory bodies. Luteolin is a natural compound that is produced by a wide range of plant species, and recent studies have shown that luteolin can inhibit the growth and alter the morphological of GAS. Here, we reported that luteolin can weaken the cytotoxicity and hemolytic activity of SLO in vitro. Briefly, luteolin bound SLO with high affinity, inhibited its dissolution of erythrocytes, affected its conformational stability and inhibited the formation of oligomers. To further verify the protective effect of luteolin, we used an in vitro SLO-induced human laryngeal carcinoma epithelial type-2 cells (HEp-2) model. Notably, our results showed luteolin protected HEp-2 cells from SLO induced cytotoxicity and changed in cell membrane permeability. In addition, we explored the role of luteolin in protecting mice from GAS-mediated injury using an aerosolized lung delivery model, and our results indicate that luteolin increases murine survival rate following inoculation with a lethal dose of GAS, and that survival was also associated with decreased pathological damage to lung tissue. Our results suggest that luteolin may be a novel drug candidate for the treatment of GAS infection.
Wall Shear Stress Predicts Media Degeneration and Biomechanical Changes in Thoracic Aorta
Authors: Kiema Miika , Sarin Jaakko K. , Kauhanen S. Petteri , Torniainen Jari , Matikka Hanna , Luoto Emma-Sofia , Jaakkola Pekka , Saari Petri , Liimatainen Timo , Vanninen Ritva , Ylä-Herttuala Seppo , Hedman Marja , Laakkonen Johanna P.
Published: July 2022

Objectives: In thoracic aortic aneurysm (TAA) of the ascending aorta (AA), AA is progressively dilating due to the weakening of the aortic wall. Predicting and preventing aortic dissections and ruptures in TAA continues to be challenging, and more accurate assessment of the AA dilatation, identification of high-risk patients, and timing of repair surgery are required. We investigated whether wall shear stress (WSS) predicts pathological and biomechanical changes in the aortic wall in TAA.

Methods: The study included 12 patients with bicuspid (BAV) and 20 patients with the tricuspid aortic valve (TAV). 4D flow magnetic resonance imaging (MRI) was performed a day before aortic replacement surgery. Biomechanical and histological parameters, including assessing of wall strength, media degeneration, elastin, and cell content were analyzed from the resected AA samples.

Results: WSSs were greater in the outer curves of the AA compared to the inner curves in all TAA patients. WSSs correlated with media degeneration of the aortic wall (ρ = -0.48, p < 0.01), elastin content (ρ = 0.47, p < 0.01), and aortic wall strength (ρ = -0.49, p = 0.029). Subsequently, the media of the outer curves was thinner, more rigid, and tolerated lower failure strains. Failure values were shown to correlate with smooth muscle cell (SMC) density (ρ = -0.45, p < 0.02), and indicated the more MYH10+ SMCs the lower the strength of the aortic wall structure. More macrophages were detected in patients with severe media degeneration and the areas with lower WSSs.

Conclusion: The findings indicate that MRI-derived WSS predicts pathological and biomechanical changes in the aortic wall in patients with TAA and could be used for identification of high-risk patients.
Interaction of Internal and External Organizations in Encouraging Community Innovation
Authors: Prasetyo Andjar , Putri Harwijayanti Bekti , Ikhwan Muhammad Nur , Lukluil Maknun Moch , Fahlevi Mochammad
Published: July 2022

An area generally has a different character from other regions, including the limited resources that exist in the area. Therefore, it is necessary to strive to encourage human resources through various interactions, and one of the efforts made is the interaction of organizational capacity in the field of innovation. The purpose of this study is to analyze and evaluate the process of organizational interaction in the field of community innovation in Magelang City, Central Java Province, Indonesia. Secondary data sources from the Magelang City Research and Development Agency were 322 innovations from 2004 to 2019, while the primary data came from structured interviews with ten innovators. The findings of the analysis are presented with a qualitative description to evaluate the interaction of innovations in the context of local government organizations. The sampling technique in the study uses accidental sampling. The analysis tool uses participatory exploration that focuses on the government's efforts as an internal organization in encouraging the community as an external organization through the interaction of innovation. The findings of this study are the formation of informal organizations in the community through the interaction of innovations carried out through internal organizational mechanisms. The finding in this study is that the organization's internal interactions in innovation are proven to be beneficial for the community which encourages the growth of community innovation, increases people's income, and contributes to increasing Magelang City's Regional Original Income.
Description of Main Innovative and Alternative Methodologies for Mathematical Learning of Written Algorithms in Primary Education
Authors: Canto López María del Carmen , Manchado Porras Malena , Piñero Charlo José Carlos , Mera Cantillo Carlos , Delgado Casas Cándida , Aragón Mendizábal Estíbaliz , García Sedeño Manuel Antonio
Published: July 2022

The traditional way of teaching mathematics generates significant learning difficulties in students that are reflected in their academic performance. In recent years, the number of teachers and researchers interested in finding innovative, flexible and comprehensible methodologies has increased. The main objective of this article has been to carry out a theoretical review of the methodologies for learning/teaching mathematics at school level. Central elements of international and national method initiatives have been highlighted. The empirical evidence on the Singapore method and the Algorithm Based on Numbers (ABN) method confirms the need to include innovative and manipulative strategies in the classroom. The Singapore method has been shown as a source that improves students′ problem solving skill, mathematical competence, boosting reasoning, and a higher motivation. Some studies focused on the effectiveness of the ABN method and its influence on mathematical cognition. The use of this methodology and learning in flipped classroom have obtained significant results in teacher training. These results could provide guidance about how to improve pre-service education in Primary Bachelor’s Degree. The findings presented in the manuscript could be a basis for opening new lines of quantitative research, with the aim of analysing problem solving and the use of manipulative materials in mathematics. Thus, future research should focus on analysing the cognitive processes involved in mathematical learning, carrying out empirical studies in schools. In addition, it is necessary to improve future teachers’ training, so that they can learn about new alternatives for mathematical teaching and the available resources to be able to put it into practice. Moreover, alternative methodologies are a necessary driver for the improvement of mathematical performance both inside and outside the classroom, and also for the technological and economic development of countries.
Research on Population Mobility and Sustainable Economic Growth From a Communication Perspective
Authors: Yao Yizhong , Liu Lei
Published: July 2022

As the global economy begins to recover, tremendous efforts will be needed to build back better to ensure decent, fulfilling, and secure work for all within an environmentally sustainable economy. Based on the perspective of communication science, this paper first constructed a comprehensive evaluation system of regional economic sustainable development indicators. Next, the least square regression model, spatial effect regression model, and two-way fixed effect regression model are used to analyze the panel data in 34 provinces and cities in China. This paper makes a detailed study on how population flow and agglomeration affect economic growth and sustainable economic development. The experiment result shows that: (1) the impact of population agglomeration on sustainable economic growth has an “inverted U” non-linear characteristic. (2) Population agglomeration promotes sustainable economic development by improving the urbanization rate. Furthermore, based on the VAR model, Granger causality analysis and co-integration technique are used to study the quantitative interaction between population growth rate and economic development level in China. The result indicates that (at the 5%-level significance): (1) in the short-term, the population growth rate has no significant effect on the economic development, while the economic development level has a significant effect on the population growth rate; (2) there is a significant negative correlation between population growth rate and economic development level in the long run.
Toward the Impact of Job Satisfaction and Collective Efficacy on EFL Teachers’ Professional Commitment
Authors: Zhang Fan
Published: July 2022

Since the success of any educational system is tied to the teachers’ professional commitment, discovering the determinants of this construct seems vital. In line with this, a huge number of inquiries have evaluated the effects of personal, contextual, and professional variables on teachers’ professional commitment. However, the impacts of job satisfaction and collective efficacy have remained unclear. Against this backdrop, the current review article seeks to theoretically explain the impacts of these constructs on EFL teachers’ professional commitment using the available documents. The review findings illuminated that EFL teachers’ professional commitment heavily relies on their job satisfaction and collective efficacy beliefs. The implications for educational principals and teacher educators are finally discussed.
Psychological and Emotional Effects of Digital Technology on Digitods (14–18 Years): A Systematic Review
Authors: Limone Pierpaolo , Toto Giusi Antonia
Published: July 2022

Background

The use of smartphones and other technologies has been increasing in digitods aged 14–18 years old. To further explain this relationship and explore the gap in research, this paper will appraise the available evidence regarding the relationship digital technology use and psychological/emotional outcomes and report on the strength of the associations observed between these variables.

Methodology

To select relevant studies, five separate computerized searches of online and electronic databases were performed. These included PubMed (MEDLINE, National Library of Medicine), ScienceDirect, Cochrane, Scopus, and Web of Science to attain literature from January 2017 to April 2022. The author independently reviewed studies for eligibility as per the inclusion/exclusion criteria and extracted the data according to a priori defined criteria. Risk of bias was assessed using the Agency for Healthcare Research and Quality (AHRQ) for healthcare studies and Cochrane Risk Of Bias In Non-randomized Studies of Interventions (ROBINS-I) assessment tool.

Results

Seven studies were included in this review. A positive relationship was found between excessive digital technology usage and negative psychological and emotional outcomes in digitods aged 14–18 (p ≤ 0.005). A statistically significant difference was found between girls and boys, with girls experiencing more negative outcomes than boys.

Conclusions

As the evidence in this review is distinctive, it is imperative that further research be conducted to investigate any synergistic relationships among these variables on a larger scale in order to better advise public health initiatives to specifically target heightened digital technology usage in adolescents.
Exploring the Motivational Factors for International Students to Study in Chinese Higher Education Institutions
Authors: Yasmin Fakhra , Li Shengbing , Slaninová Gabriela
Published: July 2022

China has witnessed a remarkable surge in the enrollment of international students in recent years and the state government has made a massive investment to build key universities of international repute. These trends made it imperative to investigate the underlying motivational aspirations of foreign students arriving from diverse regions to get enrolled in public sector Chinese universities. The present study designed an in-depth survey questionnaire and collected data from 618 foreign students enrolled in postgraduate programs at seven key state universities in the Hubei province of China. The item-based, dimension-based, and variable-level analysis approach is used to systematically uncover the facets of the internationalization of Chinese higher education in the current setting. In so doing, we employ descriptive statistics, principal component analysis, ANOVA, correlation and regression estimations, and path models to ensure the robustness of empirical outcomes. In light of the push and pull factor model regarding motivational factors for foreign students to study in China, the findings of this study assert that academic pursuits mainly dictate the international student’s decision to attain higher education in China. While obtaining a foreign degree, international image prestige, and better employment prospects after the completion of the degree were the key intentions that mainly shape the students’ decision to get enrolled in Chinese universities. Furthermore, the discriminant analysis posits that international students significantly differ in their motivational dimensions to obtain a higher degree from China. As foreign students from Asia and Africa mainly have academic goals while Europeans and Americans predominantly have pleasure and enjoyment motives to study in China. The outcomes of this research can assist Chinese administrators to understand the key motivational factors for foreign students to study in China and devise a policy accordingly to attract high quality foreign talent.
An Authentic Inner Compass and Need Satisfaction as Wellbeing Resources in Bedouin Teaching Students During the COVID-19
Authors: Cohen Rinat , Slobodin Ortal
Published: July 2022

A growing body of literature suggests that students from underserved backgrounds are more vulnerable to the adverse economic, emotional, and academic effects of the current COVID-19 pandemic. While this vulnerability was attributed to multiple structural and socio-cultural barriers, little attention has been paid to the role of psychological resources in preserving wellbeing in times of crisis and change. Guided by the Self-Determination Theory (SDT), the current study examined the role of the authentic inner compass (AIC) and need-satisfaction in predicting the wellbeing of Bedouin students attending teachers' higher education institutes in the south of Israel during the COVID-19. Participants were 84 Bedouin teaching students (84.1% female) who completed online questionnaires addressing the sense of AIC, need-based experiences, psychological distress, and positive affect. Consistent with the propositions of the SDT, we found that a strong and clear sense of AIC, as well as high need satisfaction and low need frustration, were associated with lower distress and higher positive effect in Bedouin teaching students. We have also found that need satisfaction moderated the effect of the AIC on students' wellbeing so that AIC better predicted lower distress and higher positive effect when students' levels of need satisfaction were higher. Our findings lend further support to the importance of the AIC and need satisfaction to optimal functioning even in collectivist cultural contexts that do not prioritize values of autonomy. The current study provides insight into the interplay between AIC and need-based experience by describing the conditions under which AIC may be beneficial for wellbeing in times of crisis.
Assessment of Depression and Anxiety Among Admitted People With Heart Disease Conditions: A Cross-Sectional Hospital-Based Study in a Bangladeshi Population During the COVID-19
Authors: Amin Mohammad Ashraful , Ahmed Mohsin , Nahin Sabrina , Kakoly Nadira Sultana
Published: July 2022

Objective

Depression and anxiety are widespread and chronic among patients with heart disease. We wanted to determine the proportion of heart patients with depression and anxiety levels as well as factors contributing toward depression and anxiety among hospitalized heart disease patients in Dhaka, Bangladesh during the COVID-19 era.

Methods

The study comprised a total of 384 participants with a confirmed heart disease diagnosis. We conducted a cross-sectional study from 5th March to 27th June 2021. The hospital-based study admitted patients sequentially with a new or pre-existing heart disease diagnosis to one of Dhaka's two leading hospitals. The Hospital Anxiety and Depression Scale screened all individuals for depression and anxiety.

Result

Most of the respondents (88.2%) were male and within the age categories of 51–60 years (32.81%). 96.6% of the patients were married, 30% had no income, 36.6% had only completed classes 1–5, and ~47% resided in rural areas. Approximately 36% of the study participants were former smokers, with 31% current smokers. Borderline abnormal and abnormal levels of anxiety and borderline abnormal and abnormal levels of depression were found in (23.9%, 49.4%) and (55.7%, 13.3%), respectively, of hospitalized patients. Age, residence, profession, monthly income, and chronic disease were significant predictors of anxiety, while only gender remained significantly associated with depression.

Conclusion

Hospitalized Bangladeshi patients with heart disease had moderate levels of depression and anxiety. There is a need to develop a quick screening approach in hospitals dealing with hospitalized patients with heart disease to identify those needing extra evaluation and care.
Emerging Immersive Communication Systems: Overview, Taxonomy, and Good Practices for QoE Assessment
Authors: Pérez Pablo , Gonzalez-Sosa Ester , Gutiérrez Jesús , García Narciso
Published: July 2022

Several technological and scientific advances have been achieved recently in the fields of immersive systems (e.g., 360-degree/multiview video systems, augmented/mixed/virtual reality systems, immersive audio-haptic systems, etc.), which are offering new possibilities to applications and services in different communication domains, such as entertainment, virtual conferencing, working meetings, social relations, healthcare, and industry. Users of these immersive technologies can explore and experience the stimuli in a more interactive and personalized way than previous technologies (e.g., 2D video). Thus, considering the new technological challenges related to these systems and the new perceptual dimensions and interaction behaviors involved, a deep understanding of the users’ Quality of Experience (QoE) is required to satisfy their demands and expectations. In this sense, it is essential to foster the research on evaluating the QoE of immersive communication systems, since this will provide useful outcomes to optimize them and to identify the factors that can deteriorate the user experience. With this aim, subjective tests are usually performed following standard methodologies (e.g., ITU recommendations), which are designed for specific technologies and services. Although numerous user studies have been already published, there are no recommendations or standards that define common testing methodologies to be applied to evaluate immersive communication systems, such as those developed for images and video. Taking this into account, a revision of the QoE evaluation methods designed for previous technologies is required to develop robust and reliable methodologies for immersive communication systems. Thus, the objective of this paper is to provide an overview of existing immersive communication systems and related user studies, which can help on the definition of basic guidelines and testing methodologies to be used when performing user tests of immersive communication systems, such as 360-degree video-based telepresence, avatar-based social VR, cooperative AR, etc.
Embryology of the Abdominal Wall and Associated Malformations—A Review
Authors: Pechriggl Elisabeth , Blumer Michael , Tubbs R. Shane , Olewnik Łukasz , Konschake Marko , Fortélny René , Stofferin Hannes , Honis Hanne Rose , Quinones Sara , Maranillo Eva , Sanudo José
Published: July 2022

In humans, the incidence of congenital defects of the intraembryonic celom and its associated structures has increased over recent decades. Surgical treatment of abdominal and diaphragmatic malformations resulting in congenital hernia requires deep knowledge of ventral body closure and the separation of the primary body cavities during embryogenesis. The correct development of both structures requires the coordinated and fine-tuned synergy of different anlagen, including a set of molecules governing those processes. They have mainly been investigated in a range of vertebrate species (e.g., mouse, birds, and fish), but studies of embryogenesis in humans are rather rare because samples are seldom available. Therefore, we have to deal with a large body of conflicting data concerning the formation of the abdominal wall and the etiology of diaphragmatic defects. This review summarizes the current state of knowledge and focuses on the histological and molecular events leading to the establishment of the abdominal and thoracic cavities in several vertebrate species. In chronological order, we start with the onset of gastrulation, continue with the establishment of the three-dimensional body shape, and end with the partition of body cavities. We also discuss well-known human etiologies.
Effects of Winter Heating on Urban Black Carbon: Characteristics, Sources and Its Correlation with Meteorological Factors
Authors: Liu Xinyu , Wei Yangbing , Liu Xinhui , Zu Lei , Wang Bowen , Wang Shenbo , Zhang Ruiqin , Zhu Rencheng
Published: July 2022

Coal combustion for winter heating is a major source of heavy atmospheric pollution in China, while its impacts on black carbon (BC) are not yet clear. A dual-spot Aethalometer was selected to monitor the atmospheric BC concentration in Zhengzhou, China, during the heating season, which is from 15 November through 15 March of the following year, and the non-heating season (days other than heating season). The characteristics and sources of BC were analyzed, and a concentration weight trajectory (CWT) analysis was conducted. The results showed that the BC concentrations in the heating season were generally higher than those in the non-heating season. The diurnal variation in BC concentrations during heating season was bimodal, and that during the non-heating season was unimodal. The α-values in the heating and non-heating seasons indicated that combustion of coal and biomass and vehicle emissions were the major BC sources for the heating season and non-heating season, respectively. BC concentrations were positively correlated with PM2.5, PM10, CO, and NOX. There was a strong negative correlation between wind speed and BC concentrations, and that for relative humidity was the opposite. BC concentration during heating season was mainly influenced by the northwestern areas of China and the eastern part of Henan, and that in the non-heating season was mainly from the northeastern areas of China and southern Henan.