bluuebunny/crossref_metadata_2025 huggingface dataset:
Nationalism and Democratization in East Central Europe: Lessons From the Past: An Essay
Authors: Rothschild Joseph
Published: January 2019

Over the past several decades the discipline of political science has, perhaps, degraded its competence and hence its eligibility for handling this issue by saddling itself with a flawed language, or, rather, flawed use of language for doing so. At any rate, that is true of political science as written and taught in English. Not that the other social-science disciplines are in better shape (perhaps History is). Still, political scientists have, for example, committed the following intellectual offenses:
Negating the Negation: Russia, Not-Russia, and The West
Authors: Motyl Alexander J.
Published: January 2019

There is a savage irony at the core of Sovietology. Whereas the study of Soviet history and politics should have concerned itself with everything Soviet, it traditionally focused almost exclusively only on what was Russian. By ignoring the non-Russians as something not Russian and, thus, by implication, inconsequential, “Sovietology in one country” contradicted its own premises and, thereby, turned in upon, indeed even negated, itself. By setting the center over the periphery, by detaching the center from the periphery that defined the center as a center, Sovietology in effect emptied the center of its “centrality.” In so doing, Sovietology transformed itself into an inauthentic form of Russian studies—inauthentic in the sense of ostensibly being concerned with the Soviet Union, while, in reality, actually pursuing the study of something with which Sovietology was ostensibly unconcerned.
“Plus ÇA Change …”
Authors: Huttenbach Henry R.
Published: January 2019

The essays in this collection marking the twentieth anniversary of Nationalities Papers have sought to come to grips with the sudden and rapid changes that continue to shake the ex-communist states, a process that is still in its initial stages and still far from attaining a new equilibrium, whose outlines are but vaguely defined even to an expert's eye.
Emergency Department Ceiling Collapse: Response to an Internal Emergency
Authors: Barten Dennis G. , Veltmeijer Matthijs T. W. , Peters Nathalie A. L. R.
Published: January 2019

Hospital disaster resilience is often conceived as the ability to respond to external disasters. However, internal disasters appear to be more common events in hospitals than external events. This report describes the aftermath of a ceiling collapse in the emergency department of VieCuri Medical Center in Venlo, the Netherlands, on May 18, 2017. By designating the acute medical unit as a temporary emergency department, standard emergency care could be resumed within 8 hours. This unique approach might be transferrable to other hospitals in the developed world. In general, it is vital that hospital disaster plans focus on both external and internal disasters, including specific scenarios that disrupt vital hospital departments such as the emergency department. (Disaster Med Public Health Preparedness. 2019;13:829–830)
Dimension of ergodic measures and currents on
Authors: DUPONT CHRISTOPHE , ROGUE AXEL
Published: January 2019

Let $f$ be a holomorphic endomorphism of $\mathbb{P}^{2}$ of degree $d\geq 2$. We estimate the local directional dimensions of closed positive currents $S$ with respect to ergodic dilating measures $\unicode[STIX]{x1D708}$. We infer several applications. The first one is an upper bound for the lower pointwise dimension of the equilibrium measure, towards a Binder–DeMarco’s formula for this dimension. The second one shows that every current $S$ containing a measure of entropy $h_{\unicode[STIX]{x1D708}}>\log d$ has a directional dimension ${>}2$, which answers a question of de Thélin–Vigny in a directional way. The last one estimates the dimensions of the Green current of Dujardin’s semi-extremal endomorphisms.
Prosecutor v. Jean-Pierre Bemba Gombo: Judgment on the Appeal of Mr. Jean-Pierre Bemba Gombo against Trial Chamber III's “Judgment Pursuant to Article 74 of the Statute” (Int'l Crim. Ct.)
Authors: Powderly Joseph
Published: January 2019

On June 8, 2018, the Appeals Chamber of the International Criminal Court (ICC) delivered its eagerly anticipated judgment on the appeal of Jean-Pierre Bemba Gombo against his conviction by Trial Chamber III in March 2016 for war crimes (murder, rape, and pillage) and crimes against humanity (murder and rape). Bemba's conviction was notable for the variety of “firsts” it gave rise to for the ICC. As a former vice-president of the transitional government of the Democratic Republic of the Congo (DRC) and president of the Mouvement de libération du Congo (MLC), he became the most senior leader to be successfully convicted by the ICC. His conviction was the first in which an individual was found responsible for the commission of crimes pursuant to command responsibility under Article 28 of the Rome Statute. Of particular significance was the fact that this was the first conviction at the ICC for acts of rape and sexual violence committed against women and men. Finally, this was the first case in the history of international criminal law where members of the defense team were arrested, tried, and convicted of crimes against the administration of justice during the course of the trial. The trial judgment was heralded as “a turning point in the ICC's history” following the debacles in the Lubanga, Katanga, Chui, and Kenya cases. However, we now have a new addition to the list of firsts: with the Appeals Chamber's majority judgment (decided 3-2), Bemba becomes the first accused to have his conviction overturned in full.
Hydrodynamics of periodic wave energy converter arrays
Authors: Tokić Grgur , Yue Dick K. P.
Published: January 2019

We consider the hydrodynamics of wave energy converter (WEC) arrays consisting of periodically repeated single bodies or sub-arrays. Of special interest is the array gain due to wave interactions as a function of the spatial configuration of the array. For simplicity, we assume identical WECs oscillating in heave only, although the results should extend to general motions. We find that array gains can be as high as $O(10)$ compared to the same WECs operating in isolation. We show that prominent decreases in array gain are associated with Laue resonances, involving the incident and scattered wave modes, for which we obtain an explicit condition. We also show theoretically that Bragg resonances can result in large decreases in gain with as few as two rows of strong absorbers. For general WEC geometries, we develop a multiple-scattering method of wave–body interactions applicable to generally spaced periodic arrays. For arrays of truncated vertical cylinders, we perform numerical investigations confirming our theoretical predictions for Laue and Bragg resonances. For a special class of multiple-row rectangular WEC arrays, our numerical results show that motion-trapped Rayleigh–Bloch waves can exist and be excited by an incident wave, resulting in sharp, narrow-banded spikes in the array gain.
Enhancing return to work or school after a first episode of schizophrenia: the UCLA RCT of Individual Placement and Support and Workplace Fundamentals Module training
Authors: Nuechterlein Keith H. , Subotnik Kenneth L. , Ventura Joseph , Turner Luana R. , Gitlin Michael J. , Gretchen-Doorly Denise , Becker Deborah R. , Drake Robert E. , Wallace Charles J. , Liberman Robert P.
Published: January 2019

Background

This study evaluated in a rigorous 18-month randomized controlled trial the efficacy of an enhanced vocational intervention for helping individuals with a recent first schizophrenia episode to return to and remain in competitive work or regular schooling.

Methods

Individual Placement and Support (IPS) was adapted to meet the goals of individuals whose goals might involve either employment or schooling. IPS was combined with a Workplace Fundamentals Module (WFM) for an enhanced, outpatient, vocational intervention. Random assignment to the enhanced integrated rehabilitation program (N = 46) was contrasted with equally intensive clinical treatment at UCLA, including social skills training groups, and conventional vocational rehabilitation by state agencies (N = 23). All patients were provided case management and psychiatric services by the same clinical team and received oral atypical antipsychotic medication.

Results

The IPS–WFM combination led to 83% of patients participating in competitive employment or school in the first 6 months of intensive treatment, compared with 41% in the comparison group (p < 0.005). During the subsequent year, IPS–WFM continued to yield higher rates of schooling/employment (92% v. 60%, p < 0.03). Cumulative number of weeks of schooling and/or employment was also substantially greater with the IPS–WFM intervention (45 v. 26 weeks, p < 0.004).

Conclusions

The results clearly support the efficacy of an enhanced intervention focused on recovery of participation in normative work and school settings in the initial phase of schizophrenia, suggesting potential for prevention of disability.
Martha Brill Olcott, Kazakhstan: Unfulfilled Promise.
Washington: Carnegie Endowment for Peace, 2002, xii, 321 pp. + appendices. Washington, DC.
Authors: Sabol Steven
Published: January 2019

Pessimism and skepticism dominate this most recent work by Martha Brill Olcott, one of the leading scholars of Central Asia and the Eurasian realm. Her central theme is that, even with abundant natural resources, an educated population, and a situation between East and West, Kazakhstan's seemingly bright future and promised prosperity failed to materialize. In short, political and economic corruption has dominated the transition from Soviet dependency to post-Soviet independence.
Natural phonetic tendencies and social meaning: Exploring the allophonic raising split ofpriceandmouthon the Isles of Scilly
Authors: Moore Emma , Carter Paul
Published: January 2019

The existence of an allophonic split between raised onsets before voiceless consonants and more open onsets in other environments is well-established for the vowels in thepricelexical set. It has also been observed—less frequently—for the vowels in themouthlexical set. We provide evidence of this allophonic raising split in the English spoken on the Isles of Scilly (a group of islands off the southwest coast of England) where the pattern is more robust formouththanprice. We propose that the allophonic raising split on Scilly is the outcome of dialect contact and natural phonetic tendencies, as observed elsewhere. However, by reflecting on the specifics of the location studied, and drawing on a perception study, we hypothesise that the trajectory of the pattern may be the consequence of the different social and regional qualities indexed bymouthandpriceand the interaction of these meanings with ideologies about Scilly and its speakers.
Psychological Underpinnings of Post-Truth in Political Beliefs
Authors: McDermott Rose
Published: January 2019

Although both the idea and the reality of so-called fake news or disinformation campaigns long precede the Trump administration, the frequency and intensity of the discussion around its prevalence and influence have increased significantly since Donald Trump took office. In an era when technological innovations support increasingly inexpensive and easy ways to produce media that looks official, the ability to separate real from artificial has become increasingly complicated and difficult. Some of the responsibility for public manipulation certainly rests with those who present false or artificial information as real. However, their relative success depends on, at least in part, universal psychological processes that often make humans susceptible to believing things that are not true. For example, people often weigh emotional feelings more heavily than abstract facts in their decision making. This discussion examines the psychological foundations that render individuals susceptible to a post-truth media environment and allow it to emerge, escalate, and persist.
Diurnal Cloud and Circulation Changes in Simulated Tropical Cyclones
Authors: Ruppert James H. , O'Neill Morgan E.
Published: January 2019

Observations of the diurnal cycle in tropical cyclones (TCs) systematically indicate a ∼12‐hr offset between peak rainfall rate and the maximum height of anvil clouds in the TC cloud canopy. This phasing conflicts with archetypal models of organized deep convection, which suggest a tight coupling between rainfall, vertical cloud growth, and anvil clouds. We show that this phasing owes to the bimodal diurnal evolution of the transverse circulation, which peaks nocturnally from low–midlevels, and during daytime in the upper troposphere. The bottom‐heavy nocturnal circulation state is driven by latent heating from nocturnally invigorated deep convection, while the top‐heavy daytime state is the thermally direct circulation response to strong shortwave‐cloud warming in the optically thick TC cloud canopy. This daytime upper‐level circulation response manifests in a lifting of the maximum height of the TC outflow and, in turn, a lifting and invigoration of the upper‐level anvil clouds of the TC cloud canopy.
Scaled Energy Estimation for Shallow Slow Earthquakes
Authors: Yabe Suguru , Tonegawa Takashi , Nakano Masaru
Published: January 2019

Deep and shallow slow earthquakes occur at the edge of the seismogenic zone in the Nankai subduction zone. Deep slow earthquakes occur under high‐temperature and high‐pressure conditions, whereas shallow slow earthquakes occur at lower temperatures and pressures. Although these two types of slow earthquake show qualitatively similar behaviors, such as slow deformation and depleted high‐frequency seismic signals, their similarities have not yet been evaluated in quantitative ways. In this work, we analyze shallow tectonic tremors accompanied by very low frequency earthquakes off Kii Peninsula, Japan. We estimate the seismic energy of the shallow tectonic tremors by correcting for the site amplifications of ocean bottom seismic stations and seismic attenuation in the shallow accretionary prism. The estimated seismic energy rates of these tectonic tremors are compared with seismic moment rates of accompanying very low frequency earthquakes, revealing that the scaled energy of shallow slow earthquakes is roughly constant, ~10−9 to 10−8, which is 0 to 1 order of magnitude larger than the typical scaled energy of deep slow earthquakes.
The Sensitivity of Terrestrial δ18O Gradients to Hydroclimate Evolution
Authors: Kukla Tyler , Winnick Matthew J. , Maher Kate , Ibarra Daniel E. , Chamberlain C. Page
Published: January 2019

Terrestrial gradients in the oxygen isotopic composition of meteoric water (δ18O), as reconstructed through proxies, reflect characteristics of ancient hydrologic conditions. These gradients are primarily influenced by the atmospheric transport of water vapor and the balance of precipitation and evapotranspiration, which are linked to climate and topography. We incorporate these effects into a one‐dimensional model that predicts the spatial evolution of δ18O based on local topography and the regional water‐energy budget. Specifically, we build on existing reactive transport models by incorporating parameterizations of orographic precipitation and energetic constraints on evapotranspiration following the Budyko water balance framework. We test our model on three modern transects that represent topographically distinct environments. These are the Amazon Basin (lowlands), the Cascade Range (mountains), and the eastern Himalayan Range (lowlands and mountains). Comparisons among these gradients demonstrate that the topographic regime determines how sensitive isotope records are to hydroclimate evolution. As a result, isotope records differentially express signatures of topography and the regional water balance, and we present a quantitative framework to predict this trade‐off. Finally, we link these effects to climate evolution and discuss how our model may help disentangle topographic and climatic signals through Earth history.
Reconnaissance Basement Geology and Tectonics of South Zealandia
Authors: Tulloch Andy J. , Mortimer Nick , Ireland Trevor R. , Waight Tod E. , Maas Roland , Palin J. M. , Sahoo Tusar , Seebeck Hannu , Sagar Matt W. , Barrier Andrea , Turnbull Rose E.
Published: January 2019

We report new U‐Pb zircon ages, geochemical and isotopic data for Mesozoic igneous rocks, and new seismic interpretations of mostly submerged South Zealandia (1.5 Mkm2). We use these data, along with existing geological and geophysical data sets, to refine the extent and nature of geological units. Our new 1:25 M geological map of South Zealandia provides a regional framework to investigate the rifting and breakup that formed Zealandia, Earth's most submerged continent. Samples of prerift (pre‐100 Ma) plutonic rocks can be matched with on‐land New Zealand igneous suites and indicate an east‐west strike for the subduction‐related 260 to 105‐Ma Median Batholith across the Campbell Plateau. The plutonic chronology of formerly contiguous plutonic rocks in West Antarctica reveals similar pulses and lulls to the Median Batholith. Contrary to previous interpretations, the Median Batholith does not coincide with the 1,600‐km‐long Campbell Magnetic Anomaly System. Instead we interpret the continental magnetic anomalies to represent a mainly mafic igneous unit, whose shape and extent is controlled by synrift structures related to Gondwana breakup. Correlatives of some of these unsampled igneous rocks may be exposed as circa 85 Ma alkalic volcanic rocks on the Chatham Islands. Extension directions varied by up to 65° from 100 to 80 Ma, and we suggest this allowed this large area to thin considerably before final rupture to form new oceanic crust. Synrift (90–80 Ma) structures cut the oroclinal bend in southern South Island and support a pre‐early Late Cretaceous age of orocline formation.
High‐Resolution Field Mapping and Analysis of the August–October 2016 Coseismic Surface Faulting (Central Italy Earthquakes): Slip Distribution, Parameterization, and Comparison With Global Earthquakes
Authors: Brozzetti F. , Boncio P. , Cirillo D. , Ferrarini F. , de Nardis R. , Testa A. , Liberi F. , Lavecchia G.
Published: January 2019

We focus on the coseismic surface faulting exposed along the Mt. Vettore‐Mt. Bove fault system (VBF, central Italy), that activated during the 24 August 2016, Amatrice earthquake (Mw6.0) and soon after reactivated during the 26 October Visso (Mw5.9) and 30 October Norcia events (Mw6.5 mainshock). We systematically recognized the coseismic surface ruptures of the aforesaid earthquakes, which document the repeated surface faulting on the same seismogenic structure in close temporal succession. We surveyed 1,747 evidence of coseismic ruptures, 325 fault plane attitudes along the Vettoretto‐Redentore segment, and over 4,000 data along the entire VBF that were organized in a GIS‐database. This data set allowed us to estimate the coseismic surface rupture length (SRL), maximum (MD) and average (AD) displacement associated with the Mw6.0 and Mw6.5 events. We found that the SRL and MD associated with the former are respectively 5.8 km and 28.5 cm and AD reaches 12.7 cm. For the mainshock, the values of SRL ≥ 22 km and MD = 222 cm were measured. The cumulative, post‐30 October parameters are SRL = 30 km, MD = 240 cm, AD = 36 cm. Despite that the MD of the Mw6.0 event differs by ~1 order of magnitude respect to the mainshock MD, the two slip profiles display a similar multiscale sinuosity showing a significant control of the long‐term fault segmentation on the coseismic rupturing. Comparing the obtained coseismic parameters with literature global earthquakes data highlights some peculiarities of the 2016 central Italy surface rupture pattern, which suggest caution in applying empirical relationships to highly segmented seismogenic faults.
Response of Induced Seismicity to Injection Rate Reduction: Models of Delay, Decay, Quiescence, Recovery, and Oklahoma
Authors: Dempsey David , Riffault Jeremy
Published: January 2019

When injection‐induced seismicity poses a risk to communities, it is common to reduce the injection rate or halt operations. This applies both to individual wells and well clusters, such as those within the Area of Interest for Triggered Seismicity in Western Oklahoma, where in 2016 a 40% volume reduction mandate was imposed by the state regulator. Here we quantify how induced seismicity responds to an injection reduction. We introduce models of pressure diffusion in idealized geometries coupled to steady state pressurization and rate‐state models of earthquake triggering. We find that the delay in seismicity onset and then postreduction behavior—decay, sometimes quiescence, and recovery of the seismicity rate—depend on the critical triggering pressure and on diffusion and rate‐state parameters. We have adapted our model to replicate the timing of onset, peak, and recent pace of decline of seismicity triggered by wastewater injection in Western Oklahoma. Our analysis implies that diffusivity in the Arbuckle formation is high (between 44 and 277 m2/s). The critical triggering pressure is inferred to be between 0.021 and 0.077 MPa, and fluid overpressure at 4.5‐km depth in the basement is estimated to have increased by as much as 0.190 MPa. We simulate future seismicity out to 2025 for three scenarios. Fixing the 2018 injection rate, already less than the limit imposed by the state regulator, we find a high likelihood of further M ≥ 5 earthquakes. This suggests that the volume reduction mandate in Western Oklahoma is, at present levels, inadequate.
The Geophysical Signatures of Soil Structure
Authors: Romero-Ruiz Alejandro , Linde Niklas , Keller Thomas , Or Dani
Published: January 2019

Geophysical methods may offer new opportunities for soil structure characterization over varied spatial and temporal scales.
Unique roles of tryptophanyl-tRNA synthetase in immune control and its therapeutic implications
Authors: Jin Mirim
Published: January 2019

Tryptophanyl tRNA synthetase (WRS) is an essential enzyme as it catalyzes the ligation of tryptophan to its cognate tRNA during translation. Interestingly, mammalian WRS has evolved to acquire domains or motifs for novel functions beyond protein synthesis; WRS can also further expand its functions via alternative splicing and proteolytic cleavage. WRS is localized not only to the nucleus but also to the extracellular space, playing a key role in innate immunity, angiogenesis, and IFN-γ signaling. In addition, the expression of WRS varies significantly in different tissues and pathological states, implying that it plays unique roles in physiological homeostasis and immune defense. This review addresses the current knowledge regarding the evolution, structural features, and context-dependent functions of WRS, particularly focusing on its roles in immune regulation.
Author Correction: Single CD271 marker isolates mesenchymal stem cells from human dental pulp
Authors: Alvarez Ruth , Lee Hye-Lim , Hong Christine , Wang Cun-Yu
Published: January 2019

In the original version of this Article, Figure 1c was inadvertently assembled with a duplicate of Figure 1b. The correct image for Figure 1c, shown below, has been added in the HTML and PDF versions of the Article. This does not affect the conclusions of the study. We sincerely apologize for any inconvenience this may have caused our readers.
Interference-assisted kaleidoscopic meta-plexer for arbitrary spin-wavefront manipulation
Authors: Xu He-Xiu , Hu Guangwei , Li Ying , Han Lei , Zhao Jianlin , Sun Yunming , Yuan Fang , Wang Guang-Ming , Jiang Zhi Hao , Ling Xiaohui , Cui Tie Jun , Qiu Cheng-Wei
Published: January 2019

Achieving simultaneous polarization and wavefront control, especially circular polarization with the auxiliary degree of freedom of light and spin angular momentum, is of fundamental importance in many optical applications. Interferences are typically undesirable in highly integrated photonic circuits and metasurfaces. Here, we propose an interference-assisted metasurface-multiplexer (meta-plexer) that counterintuitively exploits constructive and destructive interferences between hybrid meta-atoms and realizes independent spin-selective wavefront manipulation. Such kaleidoscopic meta-plexers are experimentally demonstrated via two types of single-layer spin-wavefront multiplexers that are composed of spatially rotated anisotropic meta-atoms. One type generates a spin-selective Bessel-beam wavefront for spin-down light and a low scattering cross-section for stealth for spin-up light. The other type demonstrates versatile control of the vortex wavefront, which is also characterized by the orbital angular momentum of light, with frequency-switchable numbers of beams under linearly polarized wave excitation. Our findings offer a distinct interference-assisted concept for realizing advanced multifunctional photonics with arbitrary and independent spin-wavefront features. A variety of applications can be readily anticipated in optical diodes, isolators, and spin-Hall meta-devices without cascading bulky optical elements.
Inhibition of HGF/MET signaling decreases overall tumor burden and blocks malignant conversion in Tpl2-related skin cancer
Authors: Bonan Nicole F. , Kowalski David , Kudlac Kaitie , Flaherty Kira , Gwilliam J. Curtis , Falkenberg Lauren G. , Maradiaga Erik , DeCicco-Skinner Kathleen L.
Published: January 2019

Tumor progression locus 2 (Tpl2) is a member of the mitogen-activated protein kinase kinase kinase (MAP3K) family of serine/threonine kinases. Deletion of the Tpl2 gene is associated with a significantly higher number of papillomas and cutaneous squamous cell carcinomas (cSCCs). Overexpression of hepatocyte growth factor (HGF) and its receptor MET is abundant in cSCC and can lead to increased proliferation, migration, invasion or resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors. The aim of this study was to address whether the increased tumor burden in Tpl2−/− mice is due to aberrant HGF/MET signaling. C57Bl/6 wild type (WT) and Tpl2−/− mice were subjected to a two-stage chemical carcinogenesis protocol for one year. At the time of promotion half of the mice received 44 mg/kg capmatinib (INC 280), a pharmacological inihibitor of MET, in their diet. Tpl2−/− mice had signficantly higher tumor incidence and overall tumor burden compared to WT mice. Further, carcinogen-intiated Tpl2−/− mice could bypass the need for promotion, as 89% of Tpl2−/− mice given only DMBA developed papillomas. v-rasHa -transduced keratinocytes and SCCs from Tpl2−/− mice revealed an upregulation in HGF and p-MET signaling compared to WT animals. Long-term capmatinib treatment had no adverse effects in mice and capmatinib-fed Tpl2−/− mice had a 60% reduction in overall tumor burden. Further, no tumors from Tpl2−/− mice fed capmatinib underwent malignant conversion. In summary targeting MET may be a potential new strategy to combat cutaneous squamous cell carcinomas that result from dysregulation in MAPK signaling.
NOTUM inhibition increases endocortical bone formation and bone strength
Authors: Brommage Robert , Liu Jeff , Vogel Peter , Mseeh Faika , Thompson Andrea Y. , Potter David G. , Shadoan Melanie K. , Hansen Gwenn M. , Jeter-Jones Sabrina , Cui Jie , Bright Dawn , Bardenhagen Jennifer P. , Doree Deon D. , Movérare-Skrtic Sofia , Nilsson Karin H. , Henning Petra , Lerner Ulf H. , Ohlsson Claes , Sands Arthur T. , Tarver James E. , Powell David R. , Zambrowicz Brian , Liu Qingyun
Published: January 2019

The disability, mortality and costs caused by non-vertebral osteoporotic fractures are enormous. Existing osteoporosis therapies are highly effective at reducing vertebral but not non-vertebral fractures. Cortical bone is a major determinant of non-vertebral bone strength. To identify novel osteoporosis drug targets, we phenotyped cortical bone of 3 366 viable mouse strains with global knockouts of druggable genes. Cortical bone thickness was substantially elevated in Notum−/− mice. NOTUM is a secreted WNT lipase and we observed high NOTUM expression in cortical bone and osteoblasts but not osteoclasts. Three orally active small molecules and a neutralizing antibody inhibiting NOTUM lipase activity were developed. They increased cortical bone thickness and strength at multiple skeletal sites in both gonadal intact and ovariectomized rodents by stimulating endocortical bone formation. Thus, inhibition of NOTUM activity is a potential novel anabolic therapy for strengthening cortical bone and preventing non-vertebral fractures.
The synthesis and characterization of giant Calixarenes
Authors: Guérineau Vincent , Rollet Marion , Viel Stéphane , Lepoittevin Bénédicte , Costa Ludovic , Saint-Aguet Pascale , Laurent Régis , Roger Philippe , Gigmes Didier , Martini Cyril , Huc Vincent
Published: January 2019

Calixarenes are cyclic oligomers obtained by condensation of suitable p-functionalised phenols with formaldehyde, usually allowing for the synthesis of the well known small calixarenes (including up to eight phenolic subunits). We report here the discovery of much larger members of this family, exhibiting sizes up to 90 phenolic subunits: the giant calixarenes. These macrocycles are obtained according to simple, easily scalable processes, in yields up to 65%. We show that the formation of these giant macrocycles is favored by an oxygen-containing-group at the para-position of the starting phenol, high concentrations of heavy alkaline bases (rubidium or cesium hydroxides) and long reaction times. A mechanism is proposed to rationalize these observations. These giant macrocycles can also be obtained in the quasi-solid state, opening interesting perspectives in the field of calixarenes chemistry. Along with their intrinsic fundamental interest, these objects are also opening interesting applicative potentialities.
Arctic amplification is caused by sea-ice loss under increasing CO2
Authors: Dai Aiguo , Luo Dehai , Song Mirong , Liu Jiping
Published: January 2019

Warming in the Arctic has been much faster than the rest of the world in both observations and model simulations, a phenomenon known as the Arctic amplification (AA) whose cause is still under debate. By analyzing data and model simulations, here we show that large AA occurs only from October to April and only over areas with significant sea-ice loss. AA largely disappears when Arctic sea ice is fixed or melts away. Periods with larger AA are associated with larger sea-ice loss, and models with bigger sea-ice loss produce larger AA. Increased outgoing longwave radiation and heat fluxes from the newly opened waters cause AA, whereas all other processes can only indirectly contribute to AA by melting sea-ice. We conclude that sea-ice loss is necessary for the existence of large AA and that models need to simulate Arctic sea ice realistically in order to correctly simulate Arctic warming under increasing CO2.
Iron-catalyzed carboazidation of alkenes and alkynes
Authors: Xiong Haigen , Ramkumar Nagarajan , Chiou Mong-Feng , Jian Wujun , Li Yajun , Su Ji-Hu , Zhang Xinhao , Bao Hongli
Published: January 2019

Carboazidation of alkenes and alkynes holds the promise to construct valuable molecules directly from chemical feedstock therefore is significantly important. Although a few examples have been developed, there are still some unsolved problems and lack of universal methods for carboazidation of both alkenes and alkynes. Here we describe an iron-catalyzed rapid carboazidation of alkenes and alkynes, enabled by the oxidative radical relay precursor t-butyl perbenzoate. This strategy enjoys success with a broad scope of alkenes under mild conditions, and it can also work with aryl alkynes which are challenging substrates for carboazidation. A large number of diverse structures, including many kinds of amino acid precursors, fluoroalkylated vinyl azides, other specific organoazides, and 2H-azirines can be easily produced.
Room temperature multi-phonon upconversion photoluminescence in monolayer semiconductor WS2
Authors: Jadczak J. , Bryja L. , Kutrowska-Girzycka J. , Kapuściński P. , Bieniek M. , Huang Y.-S. , Hawrylak P.
Published: January 2019

Photon upconversion is an anti-Stokes process in which an absorption of a photon leads to a reemission of a photon at an energy higher than the excitation energy. The upconversion photoemission has been already demonstrated in rare earth atoms in glasses, semiconductor quantum wells, nanobelts, carbon nanotubes and atomically thin semiconductors. Here, we demonstrate a room temperature upconversion photoluminescence process in a monolayer semiconductor WS2, with energy gain up to 150 meV. We attribute this process to transitions involving trions and many phonons and free exciton complexes. These results are very promising for energy harvesting, laser refrigeration and optoelectronics at the nanoscale.
Highly compliant planar Hall effect sensor with sub 200 nT sensitivity
Authors: Granell Pablo Nicolás , Wang Guoliang , Cañon Bermudez Gilbert Santiago , Kosub Tobias , Golmar Federico , Steren Laura , Fassbender Jürgen , Makarov Denys
Published: January 2019

Being a facet of flexible electronics, mechanically reshapeable magnetic field sensorics enable novel device ideas for soft robotics, interactive devices for virtual- and augmented reality and point of care diagnostics. These applications demand mechanically compliant yet robust sensor devices revealing high sensitivity to small magnetic fields. To push the detection limit of highly compliant and linear magnetic field sensors to be in the sub-µT range, we explore a new fundamental concept for magnetic field sensing, namely the planar Hall effect in magnetic thin films. With their remarkable bendability down to 1 mm, these compliant planar Hall effect sensors allow for an efficient detection of magnetic fields as small as 200 nT with a limit of detection of 20 nT. We demonstrate the application potential of these devices as a direction (angle) as well as proximity (distance) sensors of tiny magnetic fields emanating from magnetically functionalized objects. With their intrinsic linearity and simplicity of fabrication, these compliant planar Hall effect sensors have the potential to become a standard solution for low field applications of shapeable magnetoelectronics in point of care applications and on-skin interactive electronics.
Chiral optical tweezers for optically active particles in the T-matrix formalism
Authors: Patti Francesco , Saija Rosalba , Denti Paolo , Pellegrini Giovanni , Biagioni Paolo , Iatì Maria Antonia , Maragò Onofrio M.
Published: January 2019

Modeling optical tweezers in the T-matrix formalism has been of key importance for accurate and efficient calculations of optical forces and their comparison with experiments. Here we extend this formalism to the modeling of chiral optomechanics and optical tweezers where chiral light is used for optical manipulation and trapping of optically active particles. We first use the Bohren decomposition to deal with the light scattering of chiral light on optically active particles. Thus, we show analytically that all the observables (cross sections, asymmetry parameters) are split into a helicity dependent and independent part and study a practical example of a complex resin particle with inner copper-coated stainless steel helices. Then, we apply this chiral T-matrix framework to optical tweezers where a tightly focused chiral field is used to trap an optically active spherical particle, calculate the chiral behaviour of optical trapping stiffnesses and their size scaling, and extend calculations to chiral nanowires and clusters of astrophysical interest. Such general light scattering framework opens perspectives for modeling optical forces on biological materials where optically active amino acids and carbohydrates are present.
Sex and age modulate antennal chemosensory-related genes linked to the onset of host seeking in the yellow-fever mosquito, Aedes aegypti
Authors: Tallon Anaïs Karine , Hill Sharon Rose , Ignell Rickard
Published: January 2019

The mosquitoAedes aegyptiis the primary vector for the fastest growing infectious disease in the world, dengue fever. Disease transmission heavily relies on the ability of female mosquitoes to locate their human hosts. Additionally, males may be found in close proximity to humans, where they can find mates. Host seeking behaviour of both sexes is dependent on adult sexual maturation. Identifying the molecular basis for the onset of host seeking may help to determine targets for future vector control. In this study, we investigate modulation of the host seeking behaviour and the transcript abundance of the main chemoreceptor families between sexes and across ages in newly-emerged mosquitoes. Attraction to human odour was assessed using a Y-tube olfactometer, demonstrating that both males and females display age-dependent regulation of host seeking. The largest increase in transcript abundance was identified for select chemosensory genes in the antennae of young adultAe.aegyptimosquitoes and reflects the increase in attraction to human odour observed between 1 and 3 day(s) post-emergence in both males and females. Future functional characterisation of the identified differentially abundant genes may provide targets for the development of novel control strategies against vector borne diseases.
Achieving superelasticity in additively manufactured NiTi in compression without post-process heat treatment
Authors: Shayesteh Moghaddam Narges , Saedi Soheil , Amerinatanzi Amirhesam , Hinojos Alejandro , Ramazani Ali , Kundin Julia , Mills Michael J. , Karaca Haluk , Elahinia Mohammad
Published: January 2019

Shape memory alloys (SMAs), such as Nitinol (i.e., NiTi), are of great importance in biomedical and engineering applications due to their unique superelasticity and shape memory properties. In recent years, additive manufacturing (AM) processes have been used to produce complex NiTi components, which provide the ability to tailor microstructure and thus the critical properties of the alloys, such as the superelastic behavior and transformation temperatures (TTs), by selection of processing parameters. In biomedical applications, superelasticity in implants play a critical role since it gives the implants bone-like behavior. In this study, a methodology of improving superelasticity in Ni-rich NiTi components without the need for any kind of post-process heat treatments will be revealed. It will be shown that superelasticity with 5.62% strain recovery and 98% recovery ratio can be observed in Ni-rich NiTi after the sample is processed with 250 W laser power, 1250 mm/s scanning speed, and 80 µm hatch spacing without, any post-process heat treatments. This superelasticity in as-fabricated Ni-rich SLM NiTi was not previously possible in the absence of post-process heat treatments. The findings of this study promise the fast, reliable and inexpensive fabrication of complex shaped superelastic NiTi components for many envisioned applications such as patient-specific biomedical implants.
A new recombineering system for precise genome-editing in Shewanella oneidensis strain MR-1 using single-stranded oligonucleotides
Authors: Corts Anna D. , Thomason Lynn C. , Gill Ryan T. , Gralnick Jeffrey A.
Published: January 2019

Shewanella oneidensisMR-1 is an invaluable host for the discovery and engineering of pathways important for bioremediation of toxic and radioactive metals and understanding extracellular electron transfer. However, genetic manipulation is challenging due to the lack of genetic tools. Previously, the only reliable method used for introducing DNA intoShewanella spp. at high efficiency was bacterial conjugation, enabling transposon mutagenesis and targeted knockouts using suicide vectors for gene disruptions. Here, we describe development of a robust and simple electroporation method inS.oneidensisthat allows an efficiency of ~4.0 x 106transformants/µg DNA. High transformation efficiency is maintained when cells are frozen for long term storage. In addition, we report a new prophage-mediated genome engineering (recombineering) system using a λ Red Beta homolog fromShewanellasp. W3-18-1. By targeting two different chromosomal alleles, we demonstrate its application for precise genome editing using single strand DNA oligonucleotides and show that an efficiency of ~5% recombinants among total cells can be obtained. This is the first effective and simple strategy for recombination with markerless mutations inS.oneidensis. Continued development of this recombinant technology will advance high-throughput and genome modification efforts to engineer and investigateS.oneidensisand other environmental bacteria.
Enhanced Electrochemical performance at high temperature of Cobalt Oxide/Reduced Graphene Oxide Nanocomposites and its application in lithium-ion batteries
Authors: Mussa Yasmin , Ahmed Faheem , Abuhimd Hatem , Arsalan Muhammad , Alsharaeh Edreese
Published: January 2019

We report a microwave irradiation method for the preparation of reduced graphene oxide (RGO) based Co3O4 nanocomposites as anodes for lithium-ion (li-ion) batteries. The Co3O4/RGO nanocomposites displayed good electrochemical behavior as anodic materials for li-ion batteries when compared to pure Co3O4. The Co3O4/RGO nanocomposites with low RGO content resulted in stable electrochemical performance with 100% coulombic efficiency at a high current density of 500 mA/g for 50 cycles. The enhanced capacity of the Co3O4/RGO nanocomposites is due to the incorporation of RGO, which resulted in a four times larger surface area than that of Co3O4. This increased surface area could facilitate the absorption of more lithium ions, resulting in excellent electrochemical performance. Interestingly, the novelty of this work is that the designed li-ion batteries showed stable electrochemical performance even at a high temperature of 100 °C, which might be useful for rechargeable battery applications in a wide temperature range.
Compton Scattering of γ-Ray Vortex with Laguerre Gaussian Wave Function
Authors: Maruyama Tomoyuki , Hayakawa Takehito , Kajino Toshitaka
Published: January 2019

In this work, we report calculation for Compton scattering of a γ-ray vortex with a wave function of Laguerre Gaussian on an electron in the framework of the relativistic quantum mechanics. We consider the coincidence measurement of the scattered photon and the scattered electron from each Compton scattering. The momentum of the scattered photon distributes outside of the reaction plane determined by the incident photon and the scattered electron, and the energy of the scattered photon also distributes, when the scattered angle of the electron is simultaneously measured. These distributions depend on the angular momentum and the node number of the Laguerre Gaussian function of the incident photon. Thus, the coincident measurement for Compton scattering is useful to identify the nature of the vortex photon wave function.
Connexin43 mutations linked to skin disease have augmented hemichannel activity
Authors: Srinivas Miduturu , Jannace Thomas F. , Cocozzelli Anthony G. , Li Leping , Slavi Nefeli , Sellitto Caterina , White Thomas W.
Published: January 2019

Mutations in the gene (GJA1) encoding connexin43 (Cx43) are responsible for several rare genetic disorders, including non-syndromic skin-limited diseases. Here we used two different functional expression systems to characterize three Cx43 mutations linked to palmoplantar keratoderma and congenital alopecia-1, erythrokeratodermia variabilis et progressiva, or inflammatory linear verrucous epidermal nevus. In HeLa cells and Xenopus oocytes, we show that Cx43-G8V, Cx43-A44V and Cx43-E227D all formed functional gap junction channels with the same efficiency as wild-type Cx43, with normal voltage gating and a unitary conductance of ~110 pS. In HeLa cells, all three mutations also localized to regions of cell-cell contact and displayed a punctate staining pattern. In addition, we show that Cx43-G8V, Cx43-A44V and Cx43-E227D significantly increase membrane current flow through formation of active hemichannels, a novel activity that was not displayed by wild-type Cx43. The increased membrane current was inhibited by either 2 mM calcium, or 5 µM gadolinium, mediated by hemichannels with a unitary conductance of ~250 pS, and was not due to elevated mutant protein expression. The three Cx43 mutations all showed the same gain of function activity, suggesting that augmented hemichannel activity could play a role in skin-limited diseases caused by human Cx43 mutations.
Dietary fatty acid source has little effect on the development of the immune system in the pyloric caeca of Atlantic salmon fry
Authors: Jalili Mahsa , Jin Yang , Bones Atle M. , Olsen Yngvar , Vadstein Olav , Østensen Mari-Ann , Buonocore Francesco , Gerdol Marco , Pallavicini Alberto , Scapigliati Giuseppe
Published: January 2019

The quality and relative amounts of dietary lipids may affect the health and growth of cultured Atlantic salmon. So far, little is known about their effects on the performance of the fish immune system during early life stages and, in particular their importance in the transition from endogenous nutrition (yolk) in the alevin stage to exogenous nutrition in the later fry stage. We investigated the immunomodulatory effects of fish oil, vegetable oil and phospholipid-rich oil in feeds for farmed Atlantic salmon using a transcriptomic approach. The experiment allowed a fine-scale monitoring of gene expression profiles in two tissues, the pyloric caeca of the intestine and the liver, in a 94 days-long first feeding experiment. The analysis of transcriptional profiles revealed that first feeding induced a strong immunomodulation in the pyloric caeca after 48 days of feeding, lasting up to day 94 and possibly beyond. On the other hand, the differential effect of the three dietary regimes was negligible. We interpret this upregulation, undetectable in liver, as a potentiation of the immune system upon the first contact of the digestive system with exogenous feed. This process involved a complex network of gene products involved in both cellular and humoral immunity. We identified the classical pathway of the complement system, acting at the crossroads between innate and adaptive immunity, as a key process modulated in response to the switch from endogenous to exogenous nutrition.
The Generalized Analytical Expression for the Resonance Frequencies of Plasmonic Nanoresonators Composed of Folded Rectangular Geometries
Authors: Lu Hai , Li Lijun , Zhang Jun , Xia Shiqiang , Kang Xiubao , Huang Meng , Shen Kesheng , Dong Chao , Zhang Xianzhou
Published: January 2019

A robust generalized analytical expression for resonance frequencies of plasmonic nanoresonators, which consists of folded rectangular structures, is proposed based on a circuit route. The formulation is rigorously derived from the lumped circuit analogue of the plasmon resonance in a rectangular metallic nanorod. Induced by the nonhomogeneous charge distributions in the plasmonic resonators of rectangular end-caps, the electromagnetic forces drive the harmonic oscillations of free electrons in the plasmonic nanoresonators, generating intrinsically nonlinear shape-dependent LC resonance responses. Even for the plasmonic nanoresonators with much larger structure sizes than the skin depths, the significant frequency deviations due to the phase-retardation behavior can still be adequately described by the generalized expression. Moreover, for a large range of plasmonic nanoresonators with various folded rectangular geometries, sizes and materials, the generalized analytical expression gives the underlining physics and provides accurate predictions, which are perfectly verified by a series of numerical simulations. Our studies not only offer quantitative insights of nearly any plasmonic nanoresonators based on folded rectangular geometries, but also reveal potential applications to design complex plasmonic systems, such as periodic arrays with embedded rectangular nanoresonators.