bluuebunny/crossref_metadata_2025 huggingface dataset:
Regulation of abnormal expression of hsa_circRNA_0127523 on proliferation, migration and invasion and miR-515-5p expression in oral squamous cell carcinoma
Authors: Wei Jianing , Wang Zekun , Gao Jiping , Liang Yuxiang , Xu Guoqiang , Wang Xiaotang , Xiao Lanfei , Yan Xiaoru , Song Guohua
Published: January 2021

Circular RNA (circRNA) play an important role in many biological processes of occurrence and development of cancers. In this research, we established an animal model by DMBA-induced buccal sac tissue and discovered the differential expression of circRNAs by the second-generation sequencing. Models were identified by HE staining and ultrastructural observation. We found total of 3485 circRNAs were differentially expressed which the top 8 different expression circRNAs in sequencing results were confirmed by qRT-PCR. GO and KEGG analyses showed that differently expressed circRNAs function and pathway. Moreover, the axis relationship of circRNA-miRNA was predicted by miRanda. Silencing hsa_circ_0127523 significantly suppressed the proliferation, migration and invasion abilities of oral squamous cell carcinoma (OSCC) cells by RNAi, CCK-8, transwell migration and invasion assays. Furthermore, bioinformatics databases suggested that hsa_circ_0127523 might function by sponging miR-515-5p to regulate the expression of TRIP13. It was subsequently identified that hsa_circ_0127523 may inhibit miR-515-5p expression and increase TRIP13 expression in the OSCC cells. In summary, the results of the present study revealed that OSCC tissues have abundant circRNAs and we firstly explore the role of the hsa_circ_0127523 in the behavior regulation of OSCC cells. Its demonstrating that hsa_circ_0127523 may be a potential biomarker and therapeutic target of OSCC.
Development of Executive Information System to Support Strategic Goals in Retail Company
Authors: Saputra Willy Johan Widjaja
Published: January 2021

One way to present accurate and actual information to the executive is to use the Executive Information System. The Executive Information System is designed for executives who need information to monitor the situation and manage company management. Problems that may arise at this time are the lack of available information for executives because of geographical barriers, for example the distance between the head ofce and branches that are far apart or executives who often work out of the ofce so that they cannot monitor the company. This is because generally the Executive Information System that exists is only available and can be accessed from within the company environment so executives who are outside the company environment cannot access the Executive Information System to get the information needed. With the existence of an intranet-based Executive Information System, it is expected to cover the shortcomings of the Executive Information System which is not based on intranets. Information needed by executives is not only available in the corporate environment but is also available at a site that can be accessed by executives via the internet, so that executives can easily access information to monitor company performance and determine company management policies even though the executive in question is at outside the corporate environment, especially those related to marketing the company’s products. The system we built proved to be very eﬀective in helping executives to control and monitor the company and make it easier to make decisions regarding company management.
MEREFLEKSIKAN KEADILAN BAGI KONSUMEN TERKAIT KEPATUTAN PROMOSI TRANSAKSI NON-TUNAI
Authors:   Peneliti Mahkamah Konstitusi Republik Indonesia, Wijayanti Winda
Published: January 2021

Although Law Number 8 of 1999 on Consumer Protection has been enforced for 20 years, there are regulations to protect consumer, and submissions to the Constitutional Court 3 times, the material of Consumer Protection Law has never been canceled and changed. This normative juridical study aims to analyze whether or not the Consumer Protection Lawneeds to be amended to fulfill the legal necessities of the community. Merchant (bank) with the Central Bank of Indonesia policy compete to provide the best promotions so that customers are interested. The selection pay with electronic money causes the powerlessness of consumers to prefer buying goods/services cheaper with cards rather than cash without any promotion of the price of goods/services or pay normal prices as inappropriate to consumers that pay non-cash. Discrimination or different treatment of the price of goods or services that harm consumers who transact in cash result unfairness does not protect the dignity of consumers.
Attitudes Toward a Proposed GPS-Based Location Tracking Smartphone App for Improving Engagement in HIV Care Among Pregnant and Postpartum Women in South Africa: Focus Group and Interview Study
Authors: Clouse Kate , Phillips Tamsin K , Mogoba Phepo , Ndlovu Linda , Bassett Jean , Myer Landon
Published: January 2021

Background

Peripartum women living with HIV in South Africa are at high risk of dropping out of care and are also a particularly mobile population, which may impact their engagement in HIV care. With the rise in mobile phone use worldwide, there is an opportunity to use smartphones and GPS location software to characterize mobility in real time.

Objective

The aim of this study was to propose a smartphone app that could collect individual GPS locations to improve engagement in HIV care and to assess potential users’ attitudes toward the proposed app.

Methods

We conducted 50 in-depth interviews (IDIs) with pregnant women living with HIV in Cape Town and Johannesburg, South Africa, and 6 focus group discussions (FGDs) with 27 postpartum women living with HIV in Cape Town. Through an open-ended question in the IDIs, we categorized “positive,” “neutral,” or “negative” reactions to the proposed app and identified key quotations. For the FGD data, we grouped the text into themes, then analyzed it for patterns, concepts, and associations and selected illustrative quotations.

Results

In the IDIs, the majority of participants (76%, 38/50) responded favorably to the proposed app. Favorable comments were related to the convenience of facilitated continued care, a sense of helpfulness on the part of the researchers and facilities, and the difficulties of trying to maintain care while traveling. Among the 4/50 participants (8%) who responded negatively, their comments were primarily related to the individual’s responsibility for their own health care. The FGDs revealed four themes: facilitating connection to care, informed choice, disclosure (intentional or unintentional), and trust in researchers.

Conclusions

Women living with HIV were overwhelmingly positive about the idea of a GPS-based smartphone app to improve engagement in HIV care. Participants reported that they would welcome a tool to facilitate connection to care when traveling and expressed trust in researchers and health care facilities. Within the context of the rapid increase of smartphone use in South Africa, these early results warrant further exploration and critical evaluation following real-world experience with the app.
COVID-19 Misinformation Trends in Australia: Prospective Longitudinal National Survey (Preprint)
Authors: Pickles Kristen , Cvejic Erin , Nickel Brooke , Copp Tessa , Bonner Carissa , Leask Julie , Ayre Julie , Batcup Carys , Cornell Samuel , Dakin Thomas , Dodd Rachael H , Isautier Jennifer M J , McCaffery Kirsten J
Published: January 2021

BACKGROUND

Misinformation about COVID-19 is common and has been spreading rapidly across the globe through social media platforms and other information systems. Understanding what the public knows about COVID-19 and identifying beliefs based on misinformation can help shape effective public health communications to ensure efforts to reduce viral transmission are not undermined.

OBJECTIVE

This study aimed to investigate the prevalence and factors associated with COVID-19 misinformation in Australia and their changes over time.

METHODS

This prospective, longitudinal national survey was completed by adults (18 years and above) across April (n=4362), May (n=1882), and June (n=1369) 2020.

RESULTS

Stronger agreement with misinformation was associated with younger age, male gender, lower education level, and language other than English spoken at home (P<.01 for all). After controlling for these variables, misinformation beliefs were significantly associated (P<.001) with lower levels of digital health literacy, perceived threat of COVID-19, confidence in government, and trust in scientific institutions. Analyses of specific government-identified misinformation revealed 3 clusters: prevention (associated with male gender and younger age), causation (associated with lower education level and greater social disadvantage), and cure (associated with younger age). Lower institutional trust and greater rejection of official government accounts were associated with stronger agreement with COVID-19 misinformation.

CONCLUSIONS

The findings of this study highlight important gaps in communication effectiveness, which must be addressed to ensure effective COVID-19 prevention.
Online Interactive Platform for COVID-19 Literature Visual Analytics: Platform Development Study (Preprint)
Authors: Moran Addy , Hampton Shawn , Dowson Scott , Dagdelen John , Trewartha Amalie , Ceder Gerbrand , Persson Kristin , Saxon Elise , Barker Andrew , Charles Lauren , Webb-Robertson Bobbie-Jo
Published: January 2021

BACKGROUND

Papers on COVID-19 are being published at a high rate and concern many different topics. Innovative tools are needed to aid researchers to find patterns in this vast amount of literature to identify subsets of interest in an automated fashion.

OBJECTIVE

We present a new online software resource with a friendly user interface that allows users to query and interact with visual representations of relationships between publications.

METHODS

We publicly released an application called PLATIPUS (Publication Literature Analysis and Text Interaction Platform for User Studies) that allows researchers to interact with literature supplied by COVIDScholar via a visual analytics platform. This tool contains standard filtering capabilities based on authors, journals, high-level categories, and various research-specific details via natural language processing and dozens of customizable visualizations that dynamically update from a researcher’s query.

RESULTS

PLATIPUS is available online and currently links to over 100,000 publications and is still growing. This application has the potential to transform how COVID-19 researchers use public literature to enable their research.

CONCLUSIONS

The PLATIPUS application provides the end user with a variety of ways to search, filter, and visualize over 100,00 COVID-19 publications.
Inversión con modelos Markov-Switching GARCH: un estudio comparativo entre México y Argentina
Authors: De La Torre Torres Oscar V.
Published: January 2021

En este artículo se estudia el empleo de modelos markovianos con cambio de régimen (Markov-Switching) de dos regímenes, varianza GARCH y con funciones de verosimiltud gaussiana o t-Student homogéneas entre regímenes. Esto para administrar activamente portafolios en la bolsa de Buenos Aires y la Bolsa Mexicana de Valores. Al realizar 996 simulaciones semanales de enero del 2000 a enero del 2019, se ejecutó la siguiente estrategia de inversión para un portafolio denominado en dólares de los EEUU: 1) invertir en el activo libre de riesgo si la probabilidad de estar en el régimen de alta volatilidad en t+1 es mayor a 50% o 2) invertir en el índice accionario en caso contrario. Los resultados sugieren que emplear modelos MS-GARCH t-Student en una administración activa lleva a un mejor desempeño en el caso argentino y los modelos MS con varianza constante y función gaussiana en el mexicano. Esto en comparación con una estrategia pasiva tipo “comprar y mantener”.
Uso de agregado de pavimento asfáltico reciclado para un pavimento rígido
Authors: Guzmán Ortiz Dulce Valeria , Hernández Zaragoza Juan Bosco , López Lara Teresa , Horta Rangel Jaime Moisés , Giraldo Posada Diego Alberto
Published: January 2021

En México, el tránsito pesado con exceso de carga es el principal responsable del deterioro de los pavimentos ha influenciado el consumo y explotación de los recursos naturales, y por ende la rehabilitación de las carreteras, el uso del Reciclado de Pavimento Asfáltico (más conocido por sus siglas en inglés RAP, Reclaimed Asphalt Pavement) se ha presentado como una técnica para reducir lo antes ya mencionado, el cual consiste en fresar el material de un pavimento flexible durante la rehabilitación de este. El objetivo de este trabajo es reutilizar dicho RAP implementando el uso máquina de Desgaste de Los Ángeles para recuperar el agregado fino empleándolo en un pavimento rígido. Mediante los ensayes de resistencia a la compresión y tensión diametral se evaluaron diferentes mezclas, RAP en Condición Recuperado Lavado, LAV, y RAP en Condición Recuperado Sin Lavar, SL, así mismo se evaluó una Mezcla de Control, MC, y el RAP en Condición Original, CO. Los agregados de las diferentes mezclas fueron cribados por el tamiz No. 8 para posterior hacer cilindros de concretos de 10 x 20 cm. Mediante los ensayos de resistencia a la compresión y tensión indirecta se evaluó el desempeño de los materiales en conjunto, y no solamente dando el uso de estos agregados RAP, si no que trabaja de manera similar que los agregados vírgenes de arena. Los resultados indican un incremento de 3.97% a compresión y en un 7.3 % a la tensión indirecta con el material LAV.
Analysis of nonlinear gas turbine models using influence coefficients
Authors: González Castillo Iván , Loboda Igor
Published: January 2021

The limited availability of gas turbine data, especially faults data and the high costs and risks of using test benches to obtain it,causes that rarely have enough data for form a fault classification. These circumstances have created the need to develop models that can provide simulated data. The quality of the data generated depends on the complexity of the thermodynamic model and the mathematical solution. A method to evaluate the accuracy of the models and their linearization capacity is presented. The method is applied to the models of a turbo shaft and a turbo fan of the commercial software GasTurb 12, as an example. It was simulated a wide database with influence of fault parameters and condition operation, then it calculed the influence matrix ""H"" and ""G"" for prove the influence theirs on behavior of the models. The results show that if the model is sufficiently accuracy, it is possible to find an adequate interval where the linearization errors are not very large and it is just possible the linearization.
COMMUNITY EMPOWERMENT IN LANDSLIDE DISASTER MITIGATION THROUGH GREEN REVITALIZATION SYSTEM TO REALIZE TANGGUH DISASTER COMMUNITY
Authors: Trisna Silvi
Published: January 2021

Bencana alam merupakan suatu yang tidak dapat dihindari dan diprediksi terjadinya. Selama kurun waktu beberapa tahun belakangan ini banyak terjadi bencana longsor di beberapa daerah yang rawan bencana. Longsor yang terjadi disebabkan karena kondisi tanah yang tidak stabil serta kurangnya kesadaran masyarakat akan menjaga lingkunagn sendiri dari bahaya longsor. Salah satu daerah yang rawan longsor adalah nagari salido kecematan IV Jurai Pesisir Selatan yang akan menerima dampak bencana longsor. Salah satu upaya yang dapat dilakukan adalah dengan memberikan pengetahuan mitigasi bencana longsor melalui revitalisasi hijau guna mewujudkan masyarakat nagari tangguh bencana. Sehingga masyarakat akan memiliki kesiapan untuk menghadapi becana dan kemampuan untuk mengurangi resiko, serta memiliki ketahanan dan kekuatan membangun kembali kehidupan setelah terkena dampak. Selain penyuluhan juga dilakukan revitalisasi hijau melalui penanaman kembali hutan yang telah gundul dengan bibit-bibit tanaman yang diharapkan dapat meningkatkan agregat tanah sehingga longsoran tanah tidak terjadi lagi. Seluruh rangkaian kegiatan pada tahap ini disebut juga sebagai model awal dalam pengurangan risiko bencana tanah longsor.
ONLINE-BASED QUIZ MAKING TRAINING FOR MATHEMATICS TEACHERS OF SMA NEGERI 3 PADANG DURING THE PANDEMIC
Authors: Mardiyah Ainil , Delyana Hafizah , Lovia Lita , Asmar Ali
Published: January 2021

The world of education is currently experiencing a very extraordinary event. The Covid-19 pandemic has a very broad impact on participants and educational institutions. Our education system must be ready to take the leap to transform online learning for all students and by all teachers. We are entering a new era to build creativity, hone student skills, and improve our quality with changes in systems, perspectives and patterns of our interactions with technology. Every individual who is in an educational environment must be able to use technology that can help the learning process, especially in schools. Likewise, with the implementation of teaching and learning at SMAN 3 Padang, the process of implementing learning in these schools currently cannot be carried out face-to-face in class as usual. Students take lessons from home. To find out the ability of teacher students, they must evaluate the learning that has been given. One of them is by giving the teacher online quizzes because face to face is no longer possible during the Covid 19 pandemic. Mathematics is one of the subjects considered difficult by students, especially for mastery of Olympic questions. For this reason, teachers are required to have creativity so that learning can be understood by students. Mathematics teachers are given training that supports this. The training that will be provided is in the form of making questions for quizzes which are carried out online. The students will solve these questions in accordance with the specified time. Teachers who take part in the training are expected to be able to motivate and evaluate students' ability to work on Olympic questions even though they are carried out online.
Bandera
Authors: Gómez Marín Jorge Enrique
Published: January 2021

Bandera
Antigenemia temprana de Cryptococcus en pacientes asintomáticos VIH positivos en Barranquilla, Colombia
Authors: Noguera-Angarita María C. , Escandón-Escobar Patricia , Silvera-Tapia Orlando , Sierra-Díaz María B. , Torres-Alvarez Nury , Camargo de la Hoz Leidy
Published: January 2021

La criptococosis meníngea presenta alta mortalidad mundial, especialmente en población VIH/sida. La OMS recomienda detectar el antígeno capsular de Cryptococcus como estrategia para un diagnóstico temprano y poder minimizar complicaciones. Objetivo: realizar antigenemia temprana de Cryptococcus mediante inmunocromatografía/ ensayo de flujo lateral en pacientes asintomáticos VIH+. Material y método: estudio descriptivo observacional; entre julio-2016 y mayo-2019 se procesaron mediante ensayo de flujo lateral, muestras de suero de 169 pacientes asintomáticos VIH+, con CD4 ≤120 cel/μL en Barranquilla, Colombia. Ante resultado positivo, se indicó profilaxis con fluconazol; se hizo seguimiento a todos los casos. Resultados: la antigenemia fue positiva en cinco pacientes (2,96%); uno falleció, cuatro recibieron profilaxis y la prueba se negativizó en dos. Los pacientes con resultado negativo inicial no desarrollaron durante el estudio sintomatología compatible con esta micosis. Discusión: el ensayo de flujo lateral de Cryptococcus está recomendado para el diagnóstico temprano de la criptococosis en población VIH/sida. Conclusión: detectar tempranamente el antígeno circulante de Cryptococcus mediante ensayo de flujo lateral en pacientes asintomáticos VIH+, permitió instaurar profilaxis oportuna, hacer seguimiento y control para reducir la mortalidad asociada con la criptococosis meníngea.
El contexto ecológico de las vedas forestales en Michoacán durante el gobierno del General Lázaro Cárdenas 1934-1940
Authors: Pérez Talavera Víctor Manuel
Published: January 2021

El siguiente trabajo aborda el contexto ecológico en que se restringieron diversas zonas forestales del Estado de Michoacán en México, esto en la década de los treinta del siglo XX durante el periodo de gobierno del General Lázaro Cárdenas del Río (1934-1940) quien se caracterizó por fomentar en el país una política de protección y de sustentabilidad de los bosques. Para el caso de Michoacán la administración cardenista tomó acciones específicas para conservar las áreas boscosas que enfrentaban mayor riesgo de devastación, y debido a su función ecológica y económica era importante proteger, como fue el caso de las regiones de Pátzcuaro, Morelia, Zitácuaro, Uruapan y Angangueo.
The Guenoa Minuanos and the Jesuit Missions among the Guaraní
Authors: Jackson Robert Howard
Published: January 2021

The Jesuit province of Paraquaria included missions established within both sedentary and non-sedentary indigenous groups. This study examines the Guenoa Minuanos and their interactions with the Jesuit mission San Francisco de Borja. The Guenoa Minuanos were a non-sedentary group that lived in the Banda Oriental, or what is today Uruguay and Rio Grande do Sul. Some bands chose to settle on the missions and particularly San Francisco de Borja, while other bands allied with the Portuguese. This study focuses on the bands that settled on the San Francisco de Borja mission.
Uso y disposición del agua en la acuicultura: ¿falta o exceso de regulación?
Authors: Esquivel López Gabriel , Ruelas Monjardín Laura Celina , Villada Canela Mariana
Published: January 2021

La importancia de la acuicultura para la alimentación a escalas internacional, nacional y local ha llevado a que su práctica se oriente hacia estrategias productivistas, que soslayan la dimensión ambiental. Esta situación se analiza en términos de las concesiones que solicitan las granjas acuícolas para el uso del agua y de los permisos de descarga de aguas residuales. En este contexto, el objetivo de este artículo es analizar en qué medida las regulaciones y los costos que rigen el uso del agua en la acuicultura en la región central de Veracruz han condicionado su aplicación, tanto en cuencas como en acuíferos. Para cumplir este objetivo se revisa el papel que tiene la acuicultura en la alimentación de la población rural, el marco legal del agua que rige la acuicultura en México, el nivel de cumplimiento y las causas que lo condicionan. Como área de estudio se toma la región central de Veracruz, porque puede ser representativa de la situación que enfrentan otras regiones del estado y del país en cuanto a falta o sobrerregulación de la actividad. Se analiza el Censo acuícola de Veracruz, el Registro Público de Derechos del Agua, de la Comisión Nacional del Agua, y la disponibilidad de agua por cuenca y acuífero. Se encontró que esta disponibilidad está en riesgo, por la falta de cumplimiento con los permisos para usos del agua, los costos y las descargas de granjas no reguladas. Esta situación se agudiza debido a que un alto porcentaje se ubica en zonas con disponibilidad limitada. De ahí que la política hídrica en materia de regulaciones deba tomar en cuenta las restricciones económicas y técnicas que enfrentan los productores para que su actividad no solo se rija por criterios productivistas, sino que también tome en cuenta la dimensión ambiental, porque el agua es el insumo principal que requieren en cantidad y calidad.
Medición de la inversión turística nacional en México: antecedentes, conceptos y una propuesta metodológica aplicada
Authors: Cerón Monroy Hazael , Jiménez Contreras Edith Adriana
Published: January 2021

La generación de datos es cada vez más una necesidad prioritaria para abonar a la narrativa de la importancia del turismo en la vida de los mexicanos. En este trabajo se destaca la importancia de medir la inversión turística nacional, ya que se han realizado diversos esfuerzos por reconocer un dato representativo del sector; sin embargo, aún no se ha construido una metodología ni tampoco una serie apropiada y continua de datos para el caso mexicano. El objetivo del artículo es proponer una metodología para la medición de la inversión nacional en el sector turístico que siga las recomendaciones de la Organización Mundial de Turismo, del Instituto Nacional de Estadística y Geografía y las experiencias internacionales. La metodología se propone en dos ámbitos: primero, en la aportación de un “marco conceptual” que define los activos y actividades turísticas donde se registran los montos de inversión; y segundo, la aportación de las “fuentes y métodos” con la creación de una Cédula de Registro, un Sistema de Registro y el método de imputación para la construcción de la serie de inversión con Fully Conditional Specification. La propuesta metodológica se sometió a prueba para conocer su viabilidad con sus fortalezas, oportunidades, debilidades y amenazas. Los resultados indicaron que la propuesta es factible, puesto que existe información no sistematizada a nivel de Secretarías de Turismo de los estados y disposición para implementarla; y, por otro lado, la aplicación del método de imputación se probó con datos obtenidos del estado de Guanajuato, que generó una serie de tiempo continua de forma satisfactoria.
Analysis of magnetic resonance spectroscopy relative metabolite ratios in mild traumatic brain injury and normative controls
Authors:   Imgen, LLC, Las Vegas, Nevada U.S., Cartwright Peter E. , Perkins Thomas G. ,   Philips Healthcare, Cleveland, Ohio U.S.,   Perkins Consultative Resources LLC, Fort Collins, Colorado U.S., Wilson Steffanie H. ,   Emmes, Rockville, Maryland U.S., Weaver Lindell K. ,   Department of Hyperbaric Medicine, Intermountain LDS Hospital and Intermountain Medical Center, Salt Lake City, Utah U.S.,   University of Utah School of Medicine, Salt Lake City, Utah U.S., Orrison William W. ,   Imgen, LLC, Las Vegas, Nevada U.S.,   Nevada Imaging Centers, Las Vegas, Nevada U.S.,   University of Nevada Las Vegas, Department of Health Physics, Las Vegas, Nevada U.S.,   Touro University Nevada, College of Osteopathic Medicine, Las Vegas, Nevada U.S.
Published: January 2021

Introduction: We evaluated magnetic resonance spectroscopy (MRS) in United States military personnel with persistent symptoms after mild traumatic brain injury (mTBI), comparing over time two groups randomized to receive hyperbaric oxygen or sham chamber sessions and a third group of normative controls. Methods: Active-duty or veteran military personnel and normative controls underwent MRS outcome measures at baseline, 13 weeks (mTBI group only), and six months. Participants received 3.0 Tesla brain MRS for analysis of water-suppressed two-dimensional (2D) multivoxel 1H-MRS of the brain using point resolved spectroscopy (PRESS) with volume selection localized above the lateral ventricles and within the brain parenchyma, of which one voxel was chosen in each hemisphere without artifact. Script-based automatic data processing was used to assess N-acetylaspartate (NAA), creatine (Cr), and choline (Cho). Metabolite ratios for white matter were then calculated for NAA/Cr (Area), Cho/Cr (Area), and Cho/NAA (Area). These ratios were compared using standard analysis methodology. Results: There were no observable differences between participants with mTBI and normative controls nor any observable changes over time in the NAA/Cr (area), Cho/Cr (area), and Cho/NAA (area) ratios. Similarly, the control and injured participants were indistinguishable. Discussion: While participants with mild TBI showed no difference in MRS compared to normative controls, our results are limited by the few voxels chosen and potentially by less sensitive MRS markers.
Diagnostic Value of Monocyte Chemoattractant Protein-1, Soluble Mannose Receptor, Presepsin, and Procalcitonin in Critically Ill Children Admitted with Suspected Sepsis
Authors: Hassuna Noha , Elgezawy Ebtesam , Mousa Suzan , AbdelAziz Reem , Ibrahem Reham , Wahed Wafaa Abdel , Nasif Khalid , Hefzy Enas
Published: January 2021

Background: The differentiation between systemic inflammatory response
syndrome (SIRS) and sepsis, which is sometimes difficult, is very
important as it determines essential treatment decisions, such as
selection, initiation, and duration of antibiotic therapy. Thus we aimed
to investigate the diagnostic value of procalcitonin (PCT), monocyte
chemoattractant protein-1 (MCP-1), soluble mannose receptor (sMR),
presepsin as early biomarkers of pediatric sepsis in comparison to SIRS
in a group of severely ill children. Methods: The study included 58 and
24 children diagnosed as having sepsis and SIRS without infection
respectively. All the plasma levels of the studied sepsis biomarkers
were measured and ROC curves were created for all the tested parameters
to discriminate between sepsis and SIRS. Results: The best
discriminative performance was for MCP-1 with AUC of 0.996 (0.986-1.005)
with sensitivity 98.3% and specificity 100%. The sMR had the highest
sensitivity (100%), with AUC equals 0.952(.0.887-1.017) and specificity
of 91.8%. The cut-off values for PCT, presepsin, sMR, and MCP-1 and
were: 2.1 ng/ml, 256 pg/ml, 24 ng/ml and 105 pg/ml, respectively. In
septic cases, both soluble Mannose Receptor and Procalcitonin have
positive correlations with the severity of sepsis (PRISM III), low GCS,
ventilatory support, use of inotropic drugs, and mortality rate (r=
0.950, 0.812, 0.795, 0.732 and 0.861respectively) for soluble Mannose
Receptor and (0.536, 0.473, 0.422, 0.305 and 0.474 respectively) for
Procalcitonin. By the logistic regression analysis, the sMR was the only
significant predictor of sepsis. Conclusion: The present study has found
that sMR, presepsin, and MCP-1 are new biomarkers that can be used to
differentiate between sepsis and SIRS in critically-ill children. These
findings may direct clinicians in their practical decision-making and
complex management of severely-ill children who need much interference
in short time.
Aerococcus urinae causing Infective endocarditis in a patient with Down’s syndrome with ventricular septal defect
Authors: LIETAERT Valentine , CORNEA Georgeta , KUCZERA-NAESSENS Perrine , MONTMUREAU Alexandre , DEWULF Gisèle , ELLA ARNAUD DZEING
Published: January 2021

Aerococcus urinae is rare in infective endocarditis. The best
known risk factors are urogenital comorbidities. We report the case of a
46-year-old male with Down’s syndrom with infective endocarditis. The
patient underwent successful treatment with amoxicillin and heart
surgery with valve replacement.He had an unknown ventricular septal
defect
Hypoglycemia In The Emergency, But What Awaits Us For Cardiac Risks In The Future?
Authors: Akhan Onur , Ardahanlı İsa
Published: January 2021

Introduction: Several homeostatic changes like an increase in
sympathoadrenal response and oxidative stress occur in hypoglycemia. As
a result of these findings, an increase in inflammation and
pre-atherogenic factors is observed and these changes may lead to
endothelial dysfunction. Aim: Our study aims to reveal possible cardiac
risks (systolic-diastolic functions and endothelial dysfunctions) in
patients who have applied to the emergency department with hypoglycemia.
Methods: This cross-sectional, case-control study included 46
hypoglycemia patients who admitted to the emergency with symptoms
compatible with hypoglycemia and diagnosed with hypoglycemia and 30
healthy volunteers. All patients were evaluated with baseline
echocardiography, tissue-doppler imaging(carotid and brachial artery).
Also, the fasting blood tests of the patients referred to the internal
medicine department were examined. Results: There were no differences
between the groups regarding age, weight, body mass index, and systolic
blood pressure. Total cholesterol, LDL, HDL, Vitamin B12, TSH, and
fasting blood glucose levels were similar in the groups’ blood tests
(all p values>0.05). We observed a statistically
significant decrease in diastolic dysfunction parameters: E/A and E/e’
ratios (respectively, p=0.020 and 0.026). It was shown that insulin
resistance was influential in forming these considerable differences.
The patient group observed that the carotid intima-media thickness was
more remarkable(p=0.001), and the brachial flow-mediated dilatation
value was smaller(p=0.003), giving an idea about endothelial functions.
Detailed Echocardıographıc Assessment in Asthmatıc Patıents
Authors: Zorlu Duygu , Boduroğlu Yalçın , Ertürk Arzu
Published: January 2021

Introduction:It has been known that there is a complex interaction
between asthma and cardiovascular physiology.Some investigations on
echocardiography and electrocardiography(ECG) in asthmatic patients
revealed many findings such as pulmonary hypertension(PHT) and
arrhythmia.In this study,we aimed to perform tissue doppler
imaging(TDIE) and conventional echocardiographic(CEI) assessment with
many indexes of arrhythmia on electrocardiography(ECG) in asthmatic
patients.Methods:A total of 89 patients,63 female(70.8%) and 26
male(29.2%),was included in this study.Patients were divided into three
groups and then each group was separated in two 2 groups as
mild-moderate and severe asthma.Results:There is no difference among
groups with respect to age,gender and anthropometric data and no
difference between groups with respect to indexes of arrhythmia on
ECG(p> 0.05).It was determined that ventricular outflow
systolic velocity recordings at aortic and pulmonary valve were
similar(p> 0.05).MAPSE,TAPSE and both ventricular diastolic
velocities on CEI were similar between groups,except for left
ventricular A wave velocity which was higher in severe asthmatic
patients(p< 0.05).No difference between groups was detected in
left atrium(LA) TDIE diastolic velocities(p>
0.05).Investigation of time intervals of both ventricular diastolic
filling velocities(e’ and a’) at the mitral lateral,septal and tricuspid
lateral annulus revealed significant difference at Pa’m- 3 and Pa’s- 3
intervals based on TDEI(p<0.05).Investigation of the LA
volumes determined that only maximal volume of the LA was higher in
severe asthmatic patients(p< 0.05).However, there is no
significant difference between LA-VpreA and LA-Vmin(p>
0.05).Conclusions:Based on these results, it can be suggested that LA
mechanical functions and intra-atrial LA electromechanical durations
were impaired in severe asthmatic patients.
Responses of crop yield, apparent potassium balance, and soil potassium status to long-term fertilization and lime addition in acidic Ultisol
Authors: Han Tianfu , Li Dongchu , Liu Kailou , Huang Jing , Zhang Lu , Zhu Xiao Yan , Shah Asad , Liu Shujun , Feng Gu , Muhammad Qaswar , Liu Lisheng , huimin zhang , Wang Boren
Published: January 2021

Soil acidification is one of the major soil degradation phenomenon in
tropical and subtropical region, which cause reductions in soil
fertility, particularly potassium (K), and declines in crop yield.
However, it remains unclear whether and how the status of K in soils and
crops changes with the application of lime to alleviate soil
acidification. Six treatments of long-term experiments (started 1990) in
subtropical region were carried out. Regardless of fertilization regime,
lime addition markedly increased grain and straw yields compared to
those yields without lime application. Lime addition also led to
significant decreases in the apparent K balances compared to soils
without lime application. The agronomic K efficiency and partial factor
productivity of K fertilizer both significantly increased after lime
application. Lime addition reduced the soil exchangeable K (EK) content
and stock, while increased soil non-exchangeable K (NEK) content and
stock. Redundancy analysis showed that K input, lime, pH, and
exchangeable calcium all significantly affected the K in soil and crops.
Path analysis showed that lime indirectly influenced soil K (EK and NEK)
by directly affecting soil pH, exchangeable calcium, K uptake and
apparent K balances. These results suggest that lime addition is a
viable strategy for improving crop yields and K fertilizer efficiency in
degraded soils caused by acidification. Lime significant increased K
uptake which lead to decreased soil EK content and stock. Additional,
lime also increased soil NEK content and stock which was regulated by
soil pH, exchangeable calcium, and crop growth.
Developing Modernization Indicators for the People’s Republic of China: Key Considerations and a Proposed Framework
Authors: Lee Minsoo , Kim Joon-Kyung , Park Myung Ho , Peng Longyun , Okazaki Tetsuji , Ishii Susumu
Published: January 2021

The People’s Republic of China (PRC) is in the process of modernization, which it expects to achieve by 2035. This requires a national indicator to gauge the progress and level of the country’s modernization drive. This working paper provides an indicator that assesses the progress in the PRC’s modernization journey, and applies this modernization indicator—structured on thematic categories, subcategories, and intersection—to the PRC’s performance, which is then compared with countries of the Organisation for Economic Co-operation and Development and the G20. The paper also examines four major policy implications of this modernization for the PRC, which will be more durable and successful if coupled with effective division of labor and synergy with stakeholders.
Head and Neck Tumors in Children: Part II
Authors: Yu Jason W. , Lopez Joseph , Afshar Salim
Published: January 2021

The following chapter will focus on common soft tissue lesions one would encounter as pediatric head and neck tumors. The selected topics covered will be cholesteatoma, craniopharyngioma, encephalocele, teratomas, dermoid cysts and pilomatrixoma. Salivary gland tumors discussed are pleomorphic adenoma, mucoepidermoid carcinoma, adenoid cystic carcinoma and acinic cell carcinoma. Vascular anomalies are covered in another section. 
Keywords: cholesteatoma, craniopharyngioma, encephalocele, teratomas, dermoid cysts, neuroblastoma, pilomatrixoma, thyroglossal duct cysts, salivary gland tumors
The Role Of Artificial Impoundments In Improving Agricultural Production In The Semi-Arid Regions Of Northern Morocco
Authors: Hmamou Mustapha , Bounakaya Boujemaa
Published: January 2021

At the end of the last century, the Rif mountains of Morocco have experienced significant changes in the level of agricultural activity, especially it concerns the increase in cannabis cultivation, which is characterized by high water requirements. For that reason, a number of Artificial Impoundments (AIs) have been constructed in the Tangier-Tetouan-Al Hoceima (TTA) region, where by August 2017 there were more than 1400 of such structures. This requires to a study the efficiency and potential negative effects of such noticeable development. It has been shown that these hydraulic structures have provided additional positive value to the agricultural sector, especially to the proscribed industry of cannabis cultivation. Regarding other effects, the present study has found that their impact on the hydraulic and hydrographic aspects at the moment is very limited and that the only major constraint for their application is related to the issue of security, which arises from the fragile geological structure that is observed in the majority of the region.
Método da análise fatorial aplicado a conjunto de dados sobre experimentação problematizadora em instituição de educação profissional e tecnológica
Authors: Borges Aurélio Ferreira , Dutra Charles Emerick Medeiros , Moraes Raquel Nogueira de
Published: January 2021

O objetivo do estudo foi o de testar a construção e a validade do questionário intitulado Produto Educacional Experimentação Problematizadora. A finalidade é propor cada passo da análise fatorial e da análise descritiva, bem como as vantagens conceituais associadas à utilização desse questionário. Foram efetivadas as Análises Fatoriais e Descritiva dos dados coletados. Os dados foram obtidos de amostra não probabilística intencional (N=157) de sujeitos, em uma população de 545 discentes do ensino Técnico em Agropecuária de Instituição Pública de Ensino. A amostra tem distribuição não normal, de acordo com os resultados do teste de Shapiro-Wilk. O questionário de opinião aplicado para a coleta de dados antes do experimento é validado, com taxa de confiabilidade através do alfa de Cronbach, com o valor de 0,812 no pré-teste, indicando assim adequação do instrumento questionário tipo Likert.
La flor de Lis de Marosa di Giorgio: entre lo especular y el surrealismo
Authors: Ramírez Fermín Gloria Angélica
Published: January 2021

En el presente artículo se analiza la configuración narrativa de La flor de lis, de Marosa di Giorgio. La conformación de su diégesis se encuentra dispuesta en una secuencia de recuerdos intercalados e insertados entre sí que deriva en una configuración de mise en abyme. En este espacio especular, los sucesos transcurren en una dimensión surrealista, en la que el espacio de la naturaleza propicio para el amor y erotismo (como es el locus amoenus) se subvierte.
Personal Discernment and Dialogue. Learning from ‘the Other’
Authors: Barnes SJ Michael
Published: January 2021

This article considers the theme of discernment in the tradition of Ignatian spirituality emanating from the Spiritual Exercises of St Ignatius of Loyola (1491-1556), the founder of the Society of Jesus (Jesuits). After a brief introduction which addresses the central problematic of bad influences that manifest themselves as good, the article turns to the life and work of two Jesuits, the 16th C English missionary to India, Thomas Stephens and the 20th C French historian and cultural critic, Michel de Certeau. Both kept up a constant dialogue with local culture in which they sought authenticity in their response to ‘events’, whether a hideous massacre which shaped the pastoral commitment and writing of Stephens in the south of the Portuguese enclave of Goa or the 1968 student-led protests in Paris that so much affected the thinking of de Certeau. Very different in terms of personal background and contemporary experience, they both share in a tradition of discernment as a virtuous response to what both would understand as the ‘wisdom of the Spirit’ revealed in their personal interactions with ‘the other’.
“Georg Elser: herói ou assassino?”: Sobre o controle de constitucionalidadedosancionamento de relatos, “narrativas” e opiniões nocivas às instituições do Estado democrático de direito
Authors: Martins Leonardo
Published: January 2021

A partir de uma decisão do Tribunal Constitucional Federal alemão, o artigo propõe sua reconstrução como exercício de avaliação de hipóteses de inconstitucionalidade. A decisão tem como objeto sentença judicial penal condenatória por crime de difamação do Estado democrático de direito em razão de manifestações trazidas em panfleto composto por teorias do chamado revisionismo histórico. A Corte verificou a inconstitucionalidade da condenação penal em razão de uma insuficiente consideração do direito fundamental à liberdade de expressão da opinião e seus limites devida pelo juízo monocrático e tribunal revisor vinculados que são ao Art. 5 I 1 da Constituição alemã. Nas decisões impugnadas, faltou principalmente uma interpretação mais rigorosa, tanto da norma penal aplicável quanto dos fatos (expressões) a ela subsumidos, que poderia ter revelado tratar-se de intervenções estatais desproporcionais na liberdade de expressão da opinião.
Críticas do direito e dos direitos de liberdade nos filmes de Quentin Tarantino
Authors: Dimoulis Dimitri , Gasparetto Lunardi Soraya
Published: January 2021

O presente artigo analisa as críticas do direito e dos direitos de liberdade que podem ser encontradas nos filmes de Quentin Tarantino, em particular no filme Hateful Eight. Nas narrativas de Tarantino reflete-se constantemente sobre o direito de portar armas, previsto na 2ª. Emenda da Constituição dos Estados Unidos, e o significado dos direitos de liberdade, incluindo o “direito” de vingança. O texto questiona as funções do direito e do Estado, mostrando suas contradições, especialmente a (impossível) delimitação entre violência legítima e ilegítima. Reflete-se também sobre o papel do direito e do Estado na busca de estabelecer a unidade nacional sem abolir as desigualdades sociais e a opressão de minorias. O Estado de Direito e de direitos parece ser, para Tarantino, uma ordem imposta com armas e sangue.
Los dueños de América Latina: las redes entre los grandes propietarios transnacionales
Authors:   Profesor, Departamento de Sociología y Antropología Social, Universitat de València, Cárdenas Julián , Robles-Rivera Francisco ,   Investigador, Instituto de Investigaciones Sociales, y profesor en la Escuela de Comunicación,Universidad de Costa Rica, Martínez-Vallejo Diego ,   Profesor asociado, Escuela de Política y Relaciones Internacionales, Universidad Sergio Arboleda, Colombia
Published: January 2021

El análisis de quiénes son los propietarios de las grandes empresas y cómo se organizan ha sido una asignatura pendiente en los estudios sobre las élites en América Latina, principalmente a nivel transnacional. Esta limitación había impedido resolver debates en torno a la emergencia de élites empresariales transnacionales en la región. Este artículo identifica a los propietarios de las empresas más grandes de América Latina y analiza las redes que forman entre ellos. Los resultados muestran la formación de una red conectada entre un reducido número de propietarios transnacionales, los cuales son, en su mayoría, corporaciones financieras de Estados Unidos y Europa. Estos hallazgos permiten discutir sobre la integración regional y el dominio de modelos económicos importados de esos territorios.
Las mujeres de las derechas latinoamericanas del siglo XXI
Authors:   Investigadora, Instituto de Estudios de América Latina y el Caribe, Universidad de Buenos Aires, y CONICET, Argentina, Giordano Verónica , Rodríguez Gina Paola
Published: January 2021

En América Latina, las primeras dos décadas del siglo xxi han sido un momento de crecimiento del liderazgo político de las mujeres. No obstante, ello no se ha visto reflejado en las investigaciones científicas recientes a nivel regional, relativamente escasas, ni aún menos en aquellas enfocadas en los partidos y movimientos de derecha. Basándose en la revisión de fuentes periodísticas y discursos de mujeres referentes de las derechas en la actualidad, este artículo busca llenar esta vacancia interrogándose sobre la trayectoria de estas mujeres y las visiones de género desplegadas en sus discursos y agendas políticas. Para ello, estudia un conjunto de mujeres de derechas latinoamericanas vinculadas o aspirantes a los más altos cargos del Poder Ejecutivo: Mireya Moscoso (Panamá), Laura Chinchilla (Costa Rica), Gabriela Michetti (Argentina), Marta Lucía Ramírez (Colombia), Keiko Fujimori (Perú) y Evelyn Martínez Fornet (Chile).