bluuebunny/crossref_metadata_2025 huggingface dataset:
Gust Response Analysis Using the Kriging Method for Laminar Flow
Authors: Sotoudeh Zahra , Barnes Caleb
Published: February 2023

This paper presents an input–output reduced-order aerodynamic model employing the kriging interpolation for laminar flow. The kriging interpolation is a regression method, particularly useful for large motions. In the targeted flow regime, the response includes unsteady vortex shedding at high angles of attack. The reduced-order model (ROM) predicts the aerodynamic response of a rigid airfoil to a ([Formula: see text]) gust under a wide range of angles of attack, gust lengths, and gust intensities. We study two algorithms for sampling training simulations, equally spaced and Latin hypercube methods. Both methods result in a ROM with an accurate prediction of aerodynamic forces and moments, given sufficient training points, particularly along the gust length axis. We use this ROM in coupling with the structural dynamics equations to study the aeroelastic response of a one-degree-of-freedom elastic airfoil. The aeroelastic gust response predictions are accurate for moderately large pitch angle deformation, using only the ROM created from computational fluid dynamics simulation of the rigid airfoil.
TRENDS IN DIGITALIZATION OF THE WORLD FINANCIAL SERVICES MARKET
Authors:   Chernihiv Polytechnic National University, Kholiavko Nataliia , Tarasenko Artem ,   Chernihiv Polytechnic National University, Kolotok Mariia ,   Chernihiv Polytechnic National University
Published: February 2023

Abstract. In the conditions of Industry 4.0, rapid globalization, growing competition in the financial services market and the entry of powerful foreign banks, maintaining a competitive position requires adaptation to changing external challenges and consumer demands. It becomes urgent tofind innovative forms of activity, which in the digitalization period involves the implementation of information technologyin the activitiesof financial institutions. The goal of the article is to identify the main trends of digitalization in the global financial services market. Methods of comparative analysis, synthesis, systematization and scientific abstraction were used to achieve this goal. The article identifies the main benefits that financial institutions and consumers of financial services obtainfrom the use ofinformation technologies (API, BigData, blockchain, cloud computing, Artificial Intelligence, Internet of Things). The implementation of modern information technology in financial institutions allows to generate innovative products, formpersonalized offers for customers, optimize financial institutions’ costs, speed up customer services processes, improve management, reduce the cyber risks, attract new customers,and increase public trust tofinancial institutions. Emphasis is puton the necessity of development of apartnership model of interaction of financial institutions with IT-compamiesand FinTech-companies. In conclusion, the authors note that the deterrents to the digitalization of the Ukrainian financial services market are:underdeveloped legislation; lack of funding for R&Dand innovation projects; low digital literacy; outdated IT-infrastructure. Intensification of digitalization of financial institutions requires significant investments, developed innovative consciousness of management and development of information infrastructure. The authors singled out the prospects for further research,namely:the formation of effective and efficient mechanisms for protecting information systems of financial institutions from cyber attacks and information leakage
SCIENTIFIC AND CONCEPTUAL PROVISIONS OF THE FUNCTIONING AND DEVELOPMENT OF THE MECHANISM OF STATE REGULATION OF ECONOMIC SYSTEMS
Authors:   Academician Yuri Bugay International University of Science and Technology, Kotelevets Dmytro
Published: February 2023

Abstract. The development of the national economy in modern realities is directly related to the processes of state regulation of economic relations. An integral part of the implementa-tion of state regulation of the economy is the mechanism of such regulation, which is a set of all parameters and elements that, in combination, will allow it to be implemented. It is alsoextremely difficult to form an effective system of state regulation of economic processes in the country, which actualizes the need for new scientific mechanisms of such regulation, which would expand the theory of state regulation of the economy, complement the theoretical, meth-odological and applied aspects of its implementation.The article, based on the analysis of the content of such concepts as "regulation", "state regulation", "state regulation of the economy", "mechanism", specifies the essence of the mechanism of state regulation of the economy, which is proposed to be considered as an or-dered system of interconnected components, namely methods, tools , forms and principles that are used and can be applied by state authorities and local self-government bodies to in-fluence the economic behavior of economic entities. Taking into account the nature of the men-tioned mechanism, the article also specifies its features.It is also justified that, taking into account the nature of the mechanism of state regulation of the economy, such a mechanism is characterized by a complex hierarchical structure of the main components, which in their interaction was considered during the analysis of the model of the specified mechanism. This made it possible toestablish that an important condition for its effective functioning is the provision of a rational and logically structured system of interac-tion between its main components: subjects, methods, forms, tools and regulatory levers. Also, the principles on the basis of which it develops and the available resources play an important role in the functioning of such a mechanism.
Conhecimento de graduandos em odontologia acerca do processo de esterilização de instrumental odontológico
Authors: Sena Leandro Rodrigues de , Picanço Paulo Roberto Barroso , Vieira Lorena Vasconcelos , Martins Luiz Filipe Barbosa , Studart Rita Mônica Borges , Sales Fernanda Maria Feitosa , Leitão Aline Kercia Adeodato , Oliveira Rosângela Maria , Gomes Livia Lisboa Ribeiro
Published: February 2023

Objetivo: Analisar o conhecimento de estudantes de odontologia acerca do processo de esterilização dos materiais em ambiente odontológico. Métodos: Estudo transversal de abordagem quantitativa-descritiva de natureza aplicada com objetivo exploratório e de procedimento documental, realizada com 56 estudantes. Resultados: Apesar de a maior parte dos acadêmicos de Odontologia desta pesquisa afirmarem que conhecem as premissas que cercam a biossegurança e o processo de esterilização e controle de microrganismos, os níveis de conhecimento se mostram superficiais. O processo de desinfecção e esterilização foram marcados pelo desconhecimento e falta de domínio por parte dos alunos acerca da temática proposta e é exigida na sua rotina odontológica. Etapas decisivas para evitar o contágio por patógenos são ineficazes, pois os alunos não dominam as técnicas de paramentação e desparamentação, apresentando déficit nos Equipamentos de Proteção Individual (EPI) que devem ser utilizados diariamente na rotina odontológica. Conclusão: A realização do presente estudo permite concluir que apesar dos acadêmicos afirmarem conhecer as premissas que cercam a biossegurança. os níveis de conhecimento se mostram superficiais quando devidamente investigados.
Synthesis, Biological Evaluation and In-silico Studies of
3-((4-(6-(Substitutedphenyl)-2-Mercaptopyrimidin-4-Yl) Phenyl) Imino)-
1-((Dimethylamino) Methyl) Indolin-2-One
Authors: Swathi Perla . , Raja S. .
Published: February 2023

A novel isatin and pyrimidine prototype derivatives 3-((4-(6-(substitutedphenyl)-2-mercaptopyrimidin-4-yl)phenyl)imino)- 1-((dimethylamino)methyl)indolin-2-one were synthesized and designed from the intermediate chalcones. The produced components were characterized, anti-tubercular and antimicrobial screening was done by agar dilution and agar-cup plate methods, respectively. From the studies, it was revealed that derivatives 5e, 5h and 5i showed increased potency. Further in-silico studies were carried out by molecular docking with the interaction of target components 5a-5j within the Mycobacterium tuberculosis enoyl-acp reductase enzyme (1ZID), drug likeness, and pharmacokinetic parameters were measured by osiris property explorer and molinspiration online toolkit respectively.
Development and Analytical Method Validation for Simultaneous
Estimation of Evoglptin Tartrate and Metformin Hydrochloride in
Combine Dosage Form
Authors: Patel Aesha A. , Kotadiya Manisha  C. , Shah Bhakti .
Published: February 2023

Metformin hydrochloride is a diabetes medication that is used orally. Evogliptin tartrate is a dipeptidyl peptidase-4 (DPP-4) inhibitor which has been authorized as a new and powerful treatment in the process of reducing glucagon-like peptide 1 (GLP-1) deficiency while increasing insulin production and decreasing glucagon levels. The current study created a simple, highly exact, and rapid reverse phase high-performance liquid chromatography (RP-HPLC) approach for the simultaneous measurement of metformin hydrochloride and evogliptin tartrate in their combined dose form. High-performance liquid chromatography (HPLC), was performed on a phenomenex Luna C18 column with a mobile phase of water 25: acetonitrile 75 (25:75) at a 1.2 mL/min flow rate, with detection at 210 and 230 nm for metformin hydrochloride.and evogliptin tartrate. The validation method comprised of several variables like linearity, accuracy, selectivity, precision, robustness and specificity. The retention time of the metformin hydrochloride and evogliptin tartrate was 2.009 and 2.956 minutes, respectively. The method procedure linear responses of metformin hydrochloride and evogliptin tartrate was found to be 1 and 0.997, respectively. The percent relative standard deviation was less than 2% for intraday variation/precision, interday variation/precision, intermediate ruggedness, and robustness. The projected technique produced excellent results for many dependent variables. The projected method showed outstanding results with respect to different dependent and independent variables like limit of detection and limit of quantitation, suitability of system, linearity range etc., linearity, accuracy, precision, and specificity. The results were within the acceptance criteria given in ICH guideline.
Synthesis and molecular docking investigations of some benzofuran derivatives containing 1,2,4-triazole moiety as potent antibacterial and antifungal agents
Authors: Bharathi Sharanappa Veerapur , Netravati L.N. , Basavaraja K.M.
Published: February 2023

Inspired by the pharmacological activities of 1, 2, 4-triazoles, a new series of 1, 2, 4-triazoles derivatives was prepared by using the key intermediate 3-amino-5-nitro-1-benzofuran-2-yl) (phenyl) methanone (2). Compound-2 on acetylation and benzoylation yielded corresponding derivatives 3a-b, which were then treated with hydrazine hydrate to produce compound (4a-b). Compounds (4a-b) when refluxed with glacial acetic acid, produce targeted molecules of 1, 2, 4-triazoles compounds (5a-b). All the newly synthesized compounds were characterized by FT IR, 1H NMR and mass spectral analysis. All the compounds were screened for their in vitro antibacterial activity and antifungal activity. Structural molecular biology and computer-assisted drug design of molecular docking studies were made on the pore-forming domain of Escherichia coli. The immunity protein of coli E7 (ImmE7) protein inhibiters of bactericidal activity (Protein Data Bank: 1COL) binding the compounds well in the active site of protein has remarkable hydrogen bonding interactions.
Similar to Crohn’s Disease, but Diagnosed with Stenotic Ischemic Enteritis or Ischemic Colitis: Case Series and a Systematic Review
Authors:   Department of Gastroenterology, Sun Yat-sen University, China, B Xiang , Q Zhang ,   Department of Gastroenterology, Sun Yat-sen University, China, C Wang ,   Department of Pathology, Sun Yat-sen University, China, X Lou ,   Department of Pathology, Sun Yat-sen University, China, M Zhang ,   Department of Pathology, Sun Yat-sen University, China, Y Huang ,   Department of Pathology, Sun Yat-sen University, China, M Zhi ,   Department of Gastroenterology, Sun Yat-sen University, China
Published: February 2023

Background and Study Aims: Stenotic ischemic enteritis or ischemic colitis, along with transmural inflammation, ulcers and strictures, is extremely similar to Crohn’s disease. We aimed to report relevant cases and perform a systematic review to help distinguish two diseases. Patients and Methods: We reviewed our institutional experience with stenotic ischemic enteritis or ischemic colitis. Besides, we performed a comprehensive literature review using Medline (OvidSP), Web of Science, PubMed, Cochrane Library, and Embase from inception to March 2022. Demographic parameters, serological indexes, imaging markers, histological features and treatment were abstracted from our cases and included literatures. Results: We reported four cases of stenotic ischemic enteritis and one stenotic is chemic colitis in our centre, and they were all male, aging 22-65 years old. Characteristics of the five patients were presented and histological examination played an essential role in discriminating them from CD. Besides, 35 patients of stenotic IE from 17 publications were included in the systematic review and the characteristics of included patients were also presented. Conclusions: The treatment to stenotic ischemic enteritis or ischemic colitis and CD was different. Although they are very similar, but they can be distinguished from each other according to demographic features, radiographic and endoscopic imaging, especially histological evaluation.
Osteochondral Lesions of the Talus (OLTs): 2 Case Reports
Authors:   Department of Orthopaedic Surgery & Traumatology II, Mohamed V Military Hospital, Faculty of Medicine and Pharmacy, Mohamed V University, Morocco, A Zaizi , R Badaoui ,   Department of Orthopaedic Surgery & Traumatology II, Mohamed V Military Hospital, Faculty of Medicine and Pharmacy, Mohamed V University, Morocco, A Oussama ,   Department of Orthopaedic Surgery & Traumatology II, Mohamed V Military Hospital, Faculty of Medicine and Pharmacy, Mohamed V University, Morocco, J Boukhris ,   Department of Orthopaedic Surgery & Traumatology II, Mohamed V Military Hospital, Faculty of Medicine and Pharmacy, Mohamed V University, Morocco, B Chafry ,   Department of Orthopaedic Surgery & Traumatology II, Mohamed V Military Hospital, Faculty of Medicine and Pharmacy, Mohamed V University, Morocco, D Benchebba ,   Department of Orthopaedic Surgery & Traumatology II, Mohamed V Military Hospital, Faculty of Medicine and Pharmacy, Mohamed V University, Morocco, M Boussouga ,   Department of Orthopaedic Surgery & Traumatology II, Mohamed V Military Hospital, Faculty of Medicine and Pharmacy, Mohamed V University, Morocco
Published: February 2023

Osteochondral Lesions of the Talus (OLTs) or (LODA) in French nomenclature are common and challenging conditions. They are typically correlated to ankle trauma; nevertheless, nontraumatic etiologies have been described. The diagnosis should be considered in the face of chronic ankle pain, particularly after a correctly treated sprain, and confirmed by CT-scan or MRI of the ankle. We report two case reports treated arthroscopically with very good outcomes.
Perioperative Care of Mega Obese (BMI >70) Patients Undergoing Bariatric Surgery
Authors:   Department of Gastroenterology Hepatology and Transplantation, Believers Church Medical College Hospital, India, S Philip , AS Mathai ,   Department of Anaesthesia, , Believers Church Medical College Hospital, India, T Mathew ,   Department of Physical Medicine and Rehabilitation, Believers Church Medical College Hospital, India, P Finny ,   Department of Endocrinology, Believers Church Medical College Hospital, India
Published: February 2023

The prevalence of obesity in the world has recently soared due to changes in life style habits. This report describes the perioperative management of a patient with one of the highest Body mass index ever reported from Asia who underwent bariatric surgery. The patient, a 32 year gentleman with a Body Mass Index 74 had Mega Obesity according to standard classification. This article discusses the management of perioperative challenges faced in mega obese patients.
Who are the Best Candidate Patients with Diabetes for Tirzepatide?
Authors:   Department of Medicine & Endocrinology Division, Olive-View-UCLA Medical Center, David-Geffen UCLA Medical School, USA, N Mikhail
Published: February 2023

Background: Tirzepatide is a dual receptor agonist of the 2 incretin hormones: Glucose-Dependent Insulinotropic Polypeptide (GIP) and Glucagon- Like Peptide-1 (GLP-1) which is was recently approved for treatment of type 2 diabetes. Objective: To define the most appropriate patients that may benefit from tirzepatide. Methods: Pubmed search until August 10, 2022. Search terms were GLP- 1, GIP, tirzepatide, efficacy, safety, obesity. Clinical trials and pertinent animal studies and reviews were included. Results: Tirzepatide was more effective in lowering hemoglobin A1c (HbA1c) levels and body weight than submaximal doses of semaglutide (1.0 mg once-weekly), dulaglutide (1.5 mg once-weekly), insulin degludec (mean daily dose 48.8 U) and insulin glargine (mean daily dose 43.5 U). In patients with type 2 diabetes and Non-Alcoholic Fatty Liver Disease (NAFLD), tirzepatide significantly decreased Liver Fat Content (LVC). Safety profile of tirzepatide was generally similar to that of GLP-1 agonists, but frequency of Gastrointestinal (GI) adverse effects are slightly higher with tirzepatide. Incidence of severe hypoglycemia (blood glucose < 54 mg/dl) is also slightly higher with tirzepatide than semaglutide and dulaglutide, but much lower than insulin degludec and glargine. Drug discontinuation rates due to adverse effects were higher with tirzepatide compared with semaglutide, dulaglutide, and insulin. Conclusions: Tirzepatide may be most appropriate for patients with type 2 diabetes who are obese, as alternative to GLP-1 agonists or basal insulin, and in patients with NAFLD.
Sensory and Motor Visual Functions in Parkinson’s Disease with Respect to Freezing of Gait Symptoms
Authors:   Department of Optometry, College of Applied Medical Sciences, King Saud University, Saudi Arabia, A Al Saqr , A AL Dleam ,   Department of Optometry, College of Applied Medical Sciences, King Saud University, Saudi Arabia, S Almutairi ,   Department of Optometry, College of Applied Medical Sciences, King Saud University, Saudi Arabia, A Alharbi ,   Department of Optometry, College of Applied Medical Sciences, King Saud University, Saudi Arabia, A Abu Sharha ,   Department of Optometry, College of Applied Medical Sciences, King Saud University, Saudi Arabia
Published: February 2023

Purpose: Investigating intraobserver and interobservers repeatability, reproducibility and limits of agreement of anterior corneal indices using three different topographers. Methods: Forty five participants were recruited, involved two examiners and two sessions. They were assessed in random order with EyeSys Vista, Medmont E-300 and manual keratometer. The corneal indices were horizontal keratometer, vertical keratometer, eccentricity and inferior superior index. Repeatability and reproducibility of corneal power measurements were assessed based on the intersession, intrasession, Intraclass Correlation Coefficient (ICC), Spearman’s correlations and agreement was evaluated by Bland Altman test (95% Limits Of Agreement, LoA). Result: All devices showed high repeatability (p < 0.01) and reproducibility (ICC>0.75) of the corneal indices. Multivariate analysis of variance showed nonsignificant findings between visits and examiners (p > 0.05), while there was a significant difference between the devices among keratometric readings (p < 0.0001). The differences between the EyeSys, Medmont and manual keratometer were significant (p < 0.01). Moderate relationship was found between the keratometric readings with the three devices (r = 0.60, p < 0.0001). The 95% LoA for EyeSys and Medmont of the keratometric readings were larger than those for the Medmont and manual keratometer (±0.3 mm). The eccentricity and inferior superior index measurements were not significantly different between the EyeSys and Medmont (p > 0.01). Conclusion: All devices exhibited excellent repeatability and reproducibility. The EyeSys is portable, repeatable, and reliable and have stable interobservers variability. Although EyeSys would not be used interchangeably with the other two devices due to lower agreement, corrected linear calculation was suggested to manage the differences between the EyeSys and the two devices.
Can we predict ambident regioselectivity using the chemical hardness?
Authors: Miranda-Quintana Ramon , Vela Alberto , De Proft Frank , Gazquez Jose L
Published: February 2023

The hard/soft acid/base (HSAB) principle is a cornerstone in our understanding of chemical reactivity preferences. Motivated by the success of the original (e.g., "global") version of this rule, a "local" counterpart was readily proposed to account for regioselectivity preferences, in particular, in ambident reactions. However, ample experimental evidence indicates that the local HSAB principle often fails to provide meaningful predictions. Here we examine the assumptions behind the standard proof of the local HSAB rule, showing that it is based on a flawed premise. By solving this issue, we show that it is critical to consider not only the charge transferred between the different reacting centers but also the charge reorganization within the non-reacting parts of the molecule. We propose different reorganization models and derive the corresponding regioselectivity rules for each.
EFL POSTGRADUATE STUDENTS’ TENDENCY IN TRANSLATING CULTURAL TERMS FROM INDONESIAN LANGUAGE TO ENGLISH (Kecenderungan Mahasiswa Magister Bahasa Inggris dalam Menerjemahkan Istilah Budaya dari Bahasa Indonesia ke Bahasa Inggris)
Authors: Baihaqi Akhmad , Arnilah NFN
Published: February 2023

Penelitian ini bertujuan untuk menganalisis kecenderungan mahasiswa terhadap domestikasi dan foreignization dalam menerjemahkan istilah budaya. Riset ini menggunakan pendekatan kualitatif dengan metode studi kasus. Partisipan yang terlibat adalah 12 orang mahasiswa pascasarjana di Program Studi Magister Bahasa Inggris pada sebuah universitas negeri di Provinsi Banten, Indonesia. Para partisipan merupakan mahasiswa semester III yang mengambil mata kuliah Advanced Translation. Data penelitian diperoleh dari hasil terjemahan mahasiswa. Mereka diminta untuk menerjemahkan beberapa istilah budaya dalam novel karya Sindhunata yang berjudul ‘Anak Bajang Menggiring Angin’ dari Bahasa Indonesia ke Bahasa Inggris. Pengamatan dilakukan ketika mahasiswa menerjemahkan. Kemudian, wawancara secara mendalam dilaksanakan untuk mendalami teknik penerjemahan yang digunakan dan kecenderungan mahasiswa dalam menentukan domestikasi atau foreignization dalam versi terjemahan mereka. Hasilnya menunjukkan bahwa sebagian besar mahasiswa (57%) cenderung mendomestikasi versi terjemahannya. Hasil wawancara juga menunjukkan ada tiga pertimbangan mahasiswa dalam mendomestikasi versi terjemahannya: (1) mereka menganggap bahwa pembaca bahasa sasaran berasal dari budaya yang berbeda; (2) mereka mampu menerjemahkan secara sepadan ke dalam bahasa sasaran; dan (3) mereka mampu menggunakan teknik penerjemahan yang tepat untuk menyelesaikan hambatan budaya dalam menerjemakan.     AbstractThis study aims at analyzing the students’ tendency toward domestication and foreignization in translating cultural terms. This study employed qualitative research through a case study. The participants were twelve postgraduate students of the English Department at one public university in Banten Province, Indonesia. They were the third semester students currently taking Advanced Translation class. The data was collected from the students’ translation works. They were asked to translate some cultural terms in Sindhunata’s Novel entitled ‘Anak Bajang Menggiring Angin’ from Indonesian Language to English. Observation was conducted while students were working. Next, an in-depth interview was conducted to find out translation techniques and students’ tendency in domesticating or foreignizing their translation versions. The result shows that the students tend to use domestication in their works (57%). The interview results also reveal that there are three considerations of choosing domestication among students: (1) they consider that the target readers are from different cultures; (2) they can transfer the equivalence meaning in the target language; and (3) they can apply appropriate translation techniques to overcome the cultural barriers.
VITALITAS BAHASA LAMPUNG DI PEKON PENENGAHAN, KECAMATAN KARYA PENGGAWA, KABUPATEN PESISIR BARAT
Authors: Budiono Satwiko , Handayani Retno , Winarti Sri
Published: February 2023

Banyaknya tempat wisata di Provinsi Lampung memengaruhi penggunaan bahasa Lampung sebagai bahasa lokal setempat. Pengaruh tersebut dapat mengarah kepada hal positif maupun negatif. Hal ini disebabkan tempat wisata tersebut dapat mendatangkan wisatawan dari luar Provinsi Lampung sehingga kontak bahasa antara penutur bahasa Lampung dengan penutur bahasa lainnya menjadi meningkat. Salah satu daerah wisata di Provinsi Lampung yang sudah terkenal hingga mancanegara terletak di Kabupaten Pesisir Barat. Daerah wisata yang terkenal terhadap keindahan pantai dan ombaknya ini memiliki bandara sehingga akses ke Kabupaten Pesisir Barat sangat mudah dari Kota Bandarlampung. Dengan demikian, dampak wisata terhadap penggunaan bahasa Lampung menarik menjadi penelitian melalui status daya hidupnya. Sehubungan dengan hal tersebut, penelitian ini berusaha menelusuri status daya hidup bahasa Lampung berdasarkan penelitian vitalitas bahasa Lampung. Lokasi penelitian berada di Pekon Penengahan, Kecamatan Karya Penggawa, Kabupaten Pesisir Barat. Hal ini disebabkan Pekon Penengahan termasuk ke dalam desa tua dan dominasi masyarakatnya adalah penutur bahasa Lampung. Di samping itu, letak Pekon Penengahan dengan beberapa objek wisata terbilang cukup dekat sehingga desa ini sangat cocok sebagai representatif penelusuran status daya hidup bahasa Lampung. Metode penelitian menggunakan metode kuantitatif dan kualitatif. Metode kualitatif berdasarkan penghitungan indeks status daya hidup bahasa Lampung, sedangkan metode kualitatif berdasarkan analisis hasil penghitungan indeks status daya hidup bahasa Lampungnya. Hasilnya, daya hidup bahasa Lampung di Pekon Penengahan, Kecamatan Karya Penggawa, Kabupaten Pesisir Barat tergolong rentan dengan persentase indeks 0.72. Hasil indeks status daya hidup ini didominasi oleh indikator pewarisan bahasa antargenerasi dan ranah penggunaan bahasanya yang bagus. Semua masyarakat dalam berbagai tingkatan masih menggunakan bahasa Lampung dalam komunikasi sehari-hari maupun pada ranah media baru.
Assessing the impacts of various factors on circular RNA reliability
Authors: Chuang Trees-Juen , Chiang Tai-Wei , Chen Chia-Ying
Published: February 2023

Circular RNAs (circRNAs) are non-polyadenylated RNAs with a continuous loop structure characterized by a non-colinear back-splice junction (BSJ). Although millions of circRNA candidates have been identified, it remains a major challenge for determining circRNA reliability because of various types of false positives. Here, we systematically assess the impacts of numerous factors related to circRNA identification, conservation, biogenesis, and function on circRNA reliability by comparisons of circRNA expression from mock and the corresponding colinear/polyadenylated RNA–depleted datasets based on three different RNA treatment approaches. Eight important indicators of circRNA reliability are determined. The relative contribution to variability explained analyses reveal that the relative importance of these factors in affecting circRNA reliability in descending order is the conservation level of circRNA, full-length circular sequences, supporting BSJ read count, both BSJ donor and acceptor splice sites at the same colinear transcript isoforms, both BSJ donor and acceptor splice sites at the annotated exon boundaries, BSJs detected by multiple tools, supporting functional features, and both BSJ donor and acceptor splice sites undergoing alternative splicing. This study thus provides a useful guideline and an important resource for selecting high-confidence circRNAs for further investigations.
Combined Effect of Phenolic Compounds and Copper on Elodea canadensis
Authors:   Irkutsk State University, Sergienko S. E. , Sukhovnina V. O. ,   Baikal Museum SB RAS, Zhdanova G. O. ,   Irkutsk State University, Saksonov M. N. ,   Irkutsk State University, Stom A. D. ,   Irkutsk State University, Enkhdul T ,   National University of Mongolia, Kashina N. F. ,   Irkutsk National Research Technical University, Ogarkov B. N. ,   Irkutsk State University, Stom D. I. ,   Irkutsk State University,   Irkutsk National Research Technical University,   Baikal Museum SB RAS
Published: February 2023

The combined effect of Cu2+ ions and dihydric phenols, hydroquinone and resorcinol, on the yield of electrolytes from shoots of Elodea canadensis was studied. The individual effects of these groups of toxicants on aquatic plants have been fairly well studied. However, their combined action remains a poorly studied issue. This led to increased interest in this topic and the relevance of the research. The test response of E. canadensis during the biotesting of polyphenols, copper, and their mixtures was the release of electrolytes from shoots. This parameter was recorded by the change in the electrical conductivity of the water in which the plant pretreated with the toxicant was placed. The toxicity of solutions of copper, polyphenols, and “copper+polyphenol” mixtures was evaluated in acute experiments: the contact time of E. canadensis shoots with the toxicant was 30 min. The experiments showed that copper (II) caused an increase in the release of electrolytes from the shoots of E. canadensis compared to the control (plants not exposed to the toxicant) in the concentration range from 0.001 to 0.0001 N. Thus, the electrical conductivity of a medium containing elodea preliminarily treated with copper (II) at a concentration of 0.0001 N increased to 35 µS after 60 min of exposure. At a content of 0.001 to 0.01 N, the index increased to 62-79 μS. At the same time, in the control, this indicator fluctuated at the level of 2.5-5.5 μS throughout the experiment. Hydroquinone caused a significant increase in the yield of electrolytes from the shoots of E. canadensis at a content of 5ꞏ10-2 M. In this case, the electrical conductivity of the medium in which the elodea treated with polyphenol was placed was 2.5 times higher than in the control (i.e. plant not exposed to toxicants). Resorcinol had a similar effect on E. canadensis at a content of 1ꞏ10 - 1 M) observed a decrease in copper toxicity under the influence of polyphenols. When biotesting mixtures of copper (II) (0.001 N, 0.0001 N) with the studied polyphenols (hydroquinone 5ꞏ10-2 M, resorcinol 1ꞏ10-1 M), a decrease in the toxicity of copper under the influence of polyphenols was observed. The considered method for assessing the toxicity of substances is suitable not only for assessing the individual effects of various pollutants, but also for identifying the combined effects of various compounds. At the same time, the technique is characterized by ease of implementation and high speed of obtaining a response (about 2 hours).
Study of the Influence of Arginine Glutamate on Reparative Processes in Rats with Food Deprivation
Authors:   National Pirogov Memorial Medical University, Department of Surgical Stomatology and Maxillofacial Surgery. 56, Pirogov Str., Vinnytsya 21018, Ukraine, Kushta A. O. , Perminov D. O. , Voloshchuk N. I. , Alchuk O. I.
Published: February 2023

The purpose of the study was to experimentally substantiate the feasibility of arginine glutamate using, for the correction of reparative disorders in rats with partial food deprivation. Materials and methods. The work uses such research methods as modeling of food deprivation according to a patented method, modeling a wound defect of rat’s skin, evaluating the healing of wound defects by taking pictures with a camera with a resolution of 12 megapixels and subsequent processing with a special computer program Universal desktop ruler, version 11, for determining the area, determination of integral indicators of total protein, albumin, glucose, urea in blood serum of rats by spectrophotometric methods (“Filicit-diagnostics”). Statistical processing of the obtained results was carried out using non-parametric methods of analysis (MANOVA-test) using Statistica 6.0 software. Differences at p<0.05 were considered significant. Results and discussion. As a result of the food crisis, the share of hungry people in the world increases every year, and in 2022 it reached 9.8% of the world population. Starvation directly and indirectly prevents the successful healing of wounds, which is also complicated by impaired liver function. Partial food deprivation was accompanied by a violation of metabolic processes in the body of rats: a decrease in body weight (about 30%, p<0.05), a probable decrease in the content of glucose (by 24.5%), total protein and albumin (by 16.1 and 26.2%, respectively, p<0.05) with a simultaneous increase in the content of indicators of nitrogen metabolism in the blood. In addition, nutritionally deficient animals had a 4.7-day delay in wound healing compared to the control group. The use of arginine glutamate, in food-deprived rats caused a reduction in the wound skin defect and was accompanied by a partial normalization of metabolic processes: the total protein content and the amount of blood albumin were higher than those in the model pathology group without correction by 10.2 and 12.9%, respectively (p<0.05), the glucose content increased (+12.2%); simultaneously blood urea content was lower by 25.2% (p<0.05). Conclusion. The obtained data are an experimental basis for further clinical studies of the possibility of practical use of arginine glutamate in the complex treatment of patients with wound processes, especially under conditions of nutritional insufficiency
Study of The Adhesion Strength of Photocomposite Enamel Sealants to the Tooth Surface
Authors:   Shupyk National Healthcare University of Ukraine. 9, Dorohozhytska St., Kyiv 04112, Ukraine, Noenko I. V. , Pavlenko O. V. ,   Shupyk National Healthcare University of Ukraine. 9, Dorohozhytska St., Kyiv 04112, Ukraine, Mochalov Yu. O. ,   Uzhhorod National University, Department of Surgical Dentistry and Clinical Subjects. 16-А, Universitetsjka Str., Uzhhorod 880015, Ukraine
Published: February 2023

The purpose of the study was to compare an adhesion strength of some modern enamel sealants to the enamel of a developing tooth which occurs without adhesive preparation of tooth surface. Materials and methods. In laboratory the shear adhesion strength to human teeth enamel without adhesive system application was compared for “Fissurit FX” (VOCO), “Clinpro™ Sealant” (3M™ ESPE™) and “Jen-Fissufil” (Jendental-Ukraine LLC). 30 samples were tested on tensometric system. Tests were performed according to requirements of ISO 4049:2019 “Dentistry – Polymer-based restorative materials” and ISO 6874:2005 “Dentistry – Polymer-based pit and fissure sealants”. Results and discussion. Performed experimental studies of sealant adhesion (without the use of adhesive systems, only with acid etching) showed that it was the largest in the domestic “Jen-Fissufil” – 9.80 ± 1.17 MPa (M=10.42 MPa, min – 7.41 MPa, max – 11.07 MPa); less in “Fissurit FX” – 9.78 ± 1.33 MPa (M=9.43 MPa, min – 8.23 MPa, max – 12.62 MPa) and “Clinpro™ Sealant” – 9.55 ± 1.88 MPa (М=8.69 MPa, min – 6.35 MPa, and max – 14.73 MPa). The performed statistical tests did not reveal any significant differences between the adhesion strength in all three subgroups. Due to the changes in the concept of dental caries development and approaches to its control that have taken place in dentistry over the past 30 years, the role of enamel sealants in achieving caries control in individual and communal prevention of dental diseases has significantly increased. The tendency to expand the indications for the use of photocomposite enamel sealants in clinical practice is also worth noting. In addition to their direct purpose, the materials can be used for “repair” and restoration of individual photocomposite fillings with minor wear and used as a lining material for the restoration of teeth with carious cavities with a high C-factor. Conclusion. In modern dentistry the use of enamel photocomposite sealants is one of the most effective and reliable methods of preventing caries of the occlusal surfaces of teeth. The study of shear adhesion to acid-etched enamel for photocomposite materials “Fissurit FX”, “Clinpro™ Sealant” and “Jen-Fissufil” did not reveal any significant differences. The technology of composite tooth enamel sealants is currently successful in clinical practice and continues to improve and develop. The development of new and quality improvement of such materials is an urgent issue for science and technology
The Effectiveness of Opinion Gaps, Reasoning, and Information Tasks in Improving Speaking Skills
Authors: Mulyani Sri , Damaianti Vismaia S , Mulyati Yeti , Sastromiharjo Andoyo
Published: February 2023

The aim of this study was to investigate the effect of using the gap task of opinion, reasoning and information on speaking skills at the secondary school level. This study used a quasi-experimental research method involving 352 students. The three experimental groups received treatment with gaps in opinion, reasoning, and information gap tasks. All groups were examined for their initial speaking ability. The experimental group was given an intervention with gaps in opinion, reasoning, and information while the control group was given a traditional intervention to improve speaking ability. After the intervention had been carried out, all groups were examined for their speaking ability. Data analysis was performed using one-way ANOVA. The results indicated that the experimental groups showed a significant increase in speaking ability compared to students in the control group in the post-test phase. Intervention from giving the gap task of opinion, reasoning, and information is more effective for improving speaking skills. Three assignments of opinion gaps, reasoning, and information can improve students' speaking fluency. Of the three assignments, the information gap assignment provides the most significant contribution compared to the gap of opinion and reasoning tasks because the instructions in the information gap task are more varied and more intensive in encouraging students to interact in various contexts. Based on these findings, the researcher recommends designing materials by creating assignments that contain gaps in opinions, reasoning, and information to achieve learning objectives.
Yedi Bölgeden Yedi Osmanlı Hükümet Konağına İlişkin Mimari Bir Analiz
Authors: TÜRKMEN Hacer Nur
Published: February 2023

Tanzimat Fermanı ve sonrasındaki yenilikler, Osmanlı’da İstanbul merkezli olmak üzere tüm Anadolu kentlerinde karşılık bulan bir dönüşümü beraberinde getirmiştir. Bunun etkisiyle yeni mekan türlerine ihtiyaç duyulmuştur. Sosyal hayatın, kentlerin, ideolojinin farklılaşması mekan üzerinden okunmak istendiğinde başta gelen yapı türlerinden biri hükümet konağı olmaktadır. Geç Osmanlı dönemi dinamiklerinin neler olduğunu anlamak, dönem içerisinde üslup birliğinin sorgulanması, İstanbul merkezli dönüşümlerin günümüz Türkiye coğrafyasını kapsayan bölgelerde nasıl var olduğu, hükümet konaklarının mimari unsurlarına ek olarak neler söylenebileceği ve kentle ilişkileri gibi konular bu çalışmanın amacını oluşturmaktadır.

Sözü edilen değişiklikler ve yapım süreçleri Cumhuriyet’in ilanından sonra da karşılık bulmuştur, hükümet konakları yeniden yapılmış veya onarılarak kullanılmaya devam edilmiştir. Bu çalışmanın kapsamında Cumhuriyet’e değin yapı türünün ilk ortaya çıktığı dönem dinamikleri incelenmiştir. Tanzimat’tan günümüze kadar olan sürecin çok girdili ve uzun bir süreç olmasının, analizi karmaşıklaştıracağı düşünülerek çalışmanın tarih aralığı sınırlandırılmıştır. Tanzimat sonrası Osmanlı’daki dönüşümlerin, batılılaşma etkilerinin İstanbul dışında Anadolu’nun diğer alanlarında nasıl karşılık bulduğunu anlamak için de çalışmanın coğrafi kapsamı sınırlandırılmış ve Osmanlı’nın o dönemki hükümet konaklarından yalnızca Türkiye sınırları içinde kalan hükümet konakları ele alınmıştır. Bu sınırlar içerisinde olan yedi bölgeden örnekler ele alınarak bölgelere bağlı farklı girdilerin etkilerinin olup olmadığı veya neler olduğu analiz edilmeye çalışılmıştır.
THERE IS ONLY HAPPY NEW YEAR WITH RESPECT AND HOPE FOR THE FUTURE
Authors: Pagan Alice Alexandre , Nicolli Aline Andréia , Silva Márcia Gorette Lima da , Nascimento Silvania Sousa do , Cassiani Suzani
Published: February 2023

The initial times of work on RBPEC were times of much learning and with that spirit we start our dialogue with our readers.It was, between crises, difficulties, setbacks, challenges and lots of learnings, that we close 2022 and, full of hope, initiate a new year. In 2023, beyond renewed hopes, we wish everyone to have the necessary disposition to rebuild the spaces of Education, Science, Science Education and the Scientific Disclosure. Yes, there’s only the possibility to make a year really new if we have a lot of hope and will to do more, better and different. We believe that in this way, and only in this way, we will make and have a happy new year.
Development directions of the gaming industry as opportunities for people with disabilities
Authors:   Wroclaw University of Economics and Business, Czerska Iwona
Published: February 2023

Purpose: The study's main objective was to identify potential directions for developing gaming and virtual reality that can contribute to bridging the exclusion of people with disabilities. The specific objectives were to isolate functioning facilities for people with disabilities in the gaming market and to identify prospects for further development of technology-affecting facilities for gamers with disabilities. Design/methodology/approach: The author discussed existing gaming solutions as facilities for people with disabilities and then presented directions for further industry development about players with various disabilities and disorders. Subsequently, the author pointed out several benefits of gaming for people with disabilities. The paper also includes the author's identified limitations of the analysis made. In the desk research method, the author used the following scientific databases: PubMed, ResearchGate, Taylor and Francis Online. The author based his considerations primarily on foreign literature on the subject. Findings: Video games can benefit people with various disabilities and disorders - improving their physical fitness, sensorimotor coordination, spatial orientation, motivation and self- confidence. Players with disabilities can experience improvements in mental health, well-being, and behavioural change. Games focused on disability as a starting point stand out enormously. Identifying barriers among players with disabilities presents an opportunity to improve game design and development practices. Social implications: Inclusivity and diversity in games mean opening up to an increasingly wide range of players - without dividing them by gender, ethnicity, cultural background or type of disability. A socially desirable approach in this regard should result in the ability to personalize characters in games with different skin colours, body sizes, and stories related to culturally diverse characters. In doing so, game designers should focus on friendly and healthy communication during gameplay. Originality/value: The author directed the article to all interested in the gaming industry, including gamers with various disabilities and disorders, to make them aware that more and more improvements are for excluded groups. The numerous benefits for gamers with disabilities speak for the right direction of the industry. In the author's opinion, it is necessary to systematically check reports from the gaming world in the context of innovative facilities that contribute to bridging the exclusion of people with disabilities. Keywords: gaming, people with disabilities, virtual reality, accessibility, inclusivity in gaming. Category of the paper: General review.
Analysis of the fourth industrial revolution in the context of innovation and the idea of technology development
Authors:   Rzeszow University of Technology, Faculty of Mechanical Engineering and Aeronautics, Czerwińska Karolina , Pacana Andrzej ,   Rzeszow University of Technology, Faculty of Mechanical Engineering and Aeronautics, Grebski Michalene ,   Colorado Mesa University
Published: February 2023

Purpose: The purpose of the study was to analyze the phenomena occurring in the industrial area as a result of the penetration and spread of new technologies and innovations within the framework of Industry 4.0, taking into account the possible forms and areas of their application in practice. Design/methodology/approach: The research method was an analysis of the literature on the Fourth Industrial Revolution and our own observation of the changes occurring in the industrial area in the context of new technologies. Findings: Currently, the industrial area and its innovative potential is conditioned by new technologies, which are increasingly (directly and indirectly) influencing production processes and manufactured products, while implying their continuous evolution. The study reveals a research gap regarding the lack of systematic research - analysis in the field of the degree and depth of the changes that have occurred, in which the products of the fourth industrial revolution affect the achievement of the adopted goals within the industrial sector and sustainable development. Research limitations/implications: Future research directions will concern the scope of implications of Industry 4.0 creations in the industrial and service sectors and their impact on the operation of business entities. Another direction of research will be the question of the validity of the division of economic sectors in view of the significant interpenetration of the material, product and service spheres. Practical implications: The results of the research indicate the possibilities of implication of Industry 4.0 creations (such as, but not limited to: advanced human-machine interfaces, Internet of Things platforms, intelligent sensors, cloud computing, 3D printing, mobile devices, data analytics and advanced algorithms, multifaceted customer interactions and their profiling) in order to increase the efficiency of processes implemented in manufacturing companies and increase their level of competitiveness. Originality/value: Filling the research gap in the analysis of creations and improvements in the industrial area resulting from the diffusion of new technologies and innovations under Industry 4.0 and the possibilities of their implications. The research is addressed to the management of business entities. Keywords: Industry 4.0, industrial revolutions, new technologies, management and quality. Category of the paper: Research paper.