bluuebunny/crossref_metadata_2025 huggingface dataset:
Control de la dilución del mineral en labores de preparación y desarrollo, aplicando un diseño de malla de perforación y voladura basado en las metodologías de Holmberg y Pearse, en una mina subterránea en la provincia de Pataz - Trujillo
Authors:   , Castillo Rodil Antoni Carlos , Zelaya Reyes Yadira Jhasmery
Published: November 2023

Esta investigación nace a raíz de la problemática identificada en una de las labores de desarrollo en la Unidad Minera Poderosa, ubicada en la provincia de Pataz – Trujillo. Evaluar el porcentaje óptimo de dilución es un problema que se viene teniendo, ya que no se está caracterizando debidamente el área de trabajo. Estandarizar las mallas de perforación suele ser un error que casi todas las empresas mineras suelen hacer, por ello se realiza este estudio con la finalidad de proponer una nueva malla de perforación según la característica de la roca en la que nos encontremos, para poder realizar un eficiente diseño nos ayudaremos de dos modelos matemáticos muy usados, pero no fusionados. El primer modelo está referido a la propuesta de Holmberg para el diseño de frentes, él propone que dividamos en cinco partes el frente, de esta forma podremos optimizar y distribuir adecuadamente los talados. El segundo modelo está propuesto por Pearse, que nos permitió hallar el burden y posteriormente el espaciamiento que debe de tener cada taladro en la malla. Ambas teorías nos ayudaran a realizar los cálculos pertinentes y óptimos para un diseño de malla de perforación, posterior a ello se utilizará el programa JK SimBlast para diseñar la malla de perforación propuesta y analizar las zonas de daño, el tonelaje adquirido y la dilución existente.
Integración de las áreas administrativas y operativas de una contrata minera con la Oficina de Gestión de Proyectos (PMO) utilizando la metodología del PMI para mejorar la ejecución, control y cierre de proyectos de ingeniería en una mina ubicada al sur del Perú
Authors:   , Vizcarra Guerreros Edwin Andrei , Lazo Zelada Jefferson Antonio
Published: November 2023

La presente investigación tiene como objetivo integrar las áreas de una empresa contratista minera con su Oficina de Gestión de Proyectos (PMO), utilizando la metodología del Instituto de Gestión de Proyectos (PMI) para mejorar la ejecución, control y cierre de proyectos de ingeniería de una unidad minera ubicada al sur del Perú. La investigación fue de tipo cuantitativa, con un diseño de estudio de datos secundarios, el cual trabaja la investigación con datos ya existentes buscando analizar las variables tanto dependientes como independientes concluyendo si hay una relación directa o indirecta entre ellas. Los datos del estudio están constituidos en base al proyecto de ingeniería que realiza la contrata minera, su estructura organizacional, la gestión contractual y las áreas del conocimiento del PMBOK. La tesis utilizó la guía PMBOK del PMI para el diseño e implementación de 3 áreas del conocimiento, las cuales son la gestión de la integración, la gestión de riesgos y gestión del alcance. Estas 3 áreas fueron seleccionadas mediante una matriz de criterios que median la prioridad y agilidad de implementación. Sin embargo, previamente, se realizó un diagnóstico de la estructura organizacional y del nivel de gestión de proyectos de la contrata minera, para después identificar las cuatro áreas del conocimiento antes mencionadas. Luego, se realizó el diseño e implementación de la metodología en base a la guía PMBOK, el cual se ha realizado en un periodo de 48 semanas. El diseño y la implementación de la metodología de integración contempla la definición y alcance de la PMO, la implementación de las 3 áreas del conocimiento y la implementación de la gestión contractual mediante un software de firmas digitales. Finalmente, se evaluó el nivel de madurez de la contrata minera en gestión de proyectos utilizando el Modelo de Madurez de Darcy Prado (MMGP), tanto a nivel de la organización como de su proyecto de ingeniería. Además, se midió los indicadores del PMBOK los cuales abarcan, procesos, tecnología y organización. En base a lo anterior se presentaron los resultados, discusiones, conclusiones y recomendaciones.
Factores sociodemográficos y características de la alimentación complementaria asociados con anemia ferropénica en niños de 6 a 12 meses de edad en Lima-Perú, 2019: un estudio de casos y controles
Authors:   , Peña Vilca Ayza Zait , Torres Gomez Lucero Milagros
Published: November 2023

Introducción: En Perú, un importante problema de salud pública que perjudica principalmente a niños menores de 18 meses es la anemia cuya causa principal se debe a la deficiencia de hierro. Es indispensable evaluar las características de la alimentación complementaria asociadas a anemia ferropénica para prevenir los efectos negativos en el desarrollo cognitivo, físico y social en los niños menores de 12 meses. Objetivos: Evaluar la asociación entre la alimentación complementaria y la anemia ferropénica en niños de 6 a 12 meses de edad de Lima-Perú, 2019. Métodos: Estudio retrospectivo de casos y controles no pareados de una base secundaria donde se estudiaron niños de 6 a 12 meses de edad de 5 establecimientos de salud materno infantil ubicados en zonas urbanas y urbano-marginales en 3 distritos de Lima en el 2019. Se analizaron 45 casos de anemia ferropénica junto con los 180 controles que fueron seleccionados de manera aleatoria. El modelo de regresión logística fue utilizado para calcular los Odds Ratio (OR) crudos y ajustados. Resultados: La muestra de 225 niños tuvo una media de edad de 9,53 ±1,96 para los casos y 8,66±2,36 para los controles. Además, de los casos, el 67% fue hombre mientras que de los controles el 50% fue varón. Las características de la alimentación complementaria no se asociaron significativamente con la anemia ferropénica. Sin embargo, se encontró asociación significativa con el sexo (aOR=2,13; IC95% 1,04 a 4,56), edad (aOR=1,20; IC95% 1,03 a 1,42) y la sesión educativa de alimentación complementaria (aOR=0,43; IC95% 0,20 a 0,90) que recibieron las madres. Conclusiones: Los patrones agonistas y antagonistas de la alimentación complementaria no se asociaron significativamente a anemia ferropénica debido a la baja frecuencia de consumo de alimentos ricos en hierro de nuestra población estudiada. El sexo y la edad del niño se asociaron a una mayor posibilidad de tener anemia; mientras que la sesión educativa de la madre sobre alimentación complementaria se asoció a tener una menor posibilidad de tener anemia ferropénica.
Centro de Interpretación de la Historia y Cultura Chanka
Authors:   , Perez Gonzales Haydee Gimena
Published: November 2023

El presente trabajo de investigación pretende ser un esquema teórico que sirva de base en la implementación del Centro de Interpretación de la Historia y Cultura Chanka, proyecto arquitectónico que se plantea para la revalorización del Complejo Arqueológico de Sóndor ubicado en el distrito de Pacucha, provincia de Andahuaylas, región de Apurímac; siendo este el espacio donde la cultura Chanka llegó a la cumbre de su desarrollo arquitectónico y cultural. En este sentido, se propone que bajo el concepto se mímesis, énfasis del proyecto, la tesis aporte una alternativa de solución dentro del marco arquitectónico, el desarrollo de espacios por medio de los cuales se expondrán y estudiarán los restos históricos pertenecientes a la cultura Chanka, los cuales se regirán bajo un lenguaje que se adapte al contexto y se integre al mismo. El planteamiento de la normativa y parámetros mínimos que se implementarán dentro del proyecto, se basan en la revisión y análisis de proyectos arquitectónicos que comparten características parecidas a la propuesta en cuanto se refiere a espacialidad, contexto, materialidad, función, organización, paquetes funcionales, etc, tomando a los mismos como base conceptual para el planteamiento del proyecto. Finalmente, es importante precisar que previo a la realización de una propuesta arquitectónica, se hizo un análisis sobre el contexto, el distrito de Pacucha, para identificación del problema central que motivo y es eje central de la propuesta y un estudio acerca del desarrollo de los antecedentes históricos y culturales de la Cultura Chanka en el distrito de Pacucha para ser tomados a consideración dentro del proyecto.
Zeuxine longilabris (Orchidaceae) – An addition to the orchid flora of Telangana state, India
Authors: Asalla Appaiah , Ravi Gollamandala , Veeranjaneyulu Dasari , Kothareddy Prasad
Published: November 2023

Zeuxine longilabris (Lindl.) Trimen, is reported for first time from the Telangana state. A detailed description and photographs of the species is provided for easy identification.
Rediscovery of the moss Dicranella pomiformis after more than a century from the Western Ghats
Authors: Athira S. , Daniels A. E. D.
Published: November 2023

The authors discovered a previously unknown population of Dicranella pomiformis in the Idukki District of Western Ghats, which is a rediscovery after more than a century. In light of this additional information, a revised detailed description of the species is presented along with a photographic plate and a distribution map.
Loxostigma puhoatense (Gesneriaceae): a new addition to Indian flora
Authors: Debta Manas Ranjan , Shenoy Akshath , Mao Ashiho Asosii
Published: November 2023

Loxostigma puhoatense (Gesneriaceae), hitherto known only from Vietnam, is reported for the first time from India. Detailed description, phenology, distribution, and colored photographs along with dissection are provided to facilitate easy identification in the field. An artificial key to Indian species of Loxostigma is also provided.
Lectotypification of Chilocarpus malabaricus (Apocynaceae), a liana endemic to Southern India
Authors: Sreeja K. , Sujana K. A.
Published: November 2023

The lectotype is designated here for the name Chilocarpus malabaricus Bedd. (Apocynaceae), an endemic species reported only from three states of India, viz., Karnataka, Kerala and Tamil Nadu.
Notes on taxonomy, distribution and threat status assessment of Habenaria andamanica Hook.f.- an endemic terrestrial orchid from Andaman Islands
Authors: Choudhury Suptotthita , Agrawala Dinesh Kumar , C.P. Vivek
Published: November 2023

Taxonomy of Habenaria andamanica Hook.f. [Orchidaceae-Orchidoideae-Orchidiinae] has been studied. It is an endemic species confined to the Andaman group of Islands. It has been assessed as ‘Endangered’ by applying the IUCN guidelines.
A antropofagia na arte de Glauco Rodrigues
Authors: Flores Maria Bernardete Ramos
Published: November 2023

Glauco Rodrigues expôs na I Bienal Latino-Americana de São Paulo (1978) um conjunto de 67 obras produzidas na década de 1970, que fazem parte de uma fase do artista, vista pela crítica como sendo antropofágica. Fundindo “banhistas ipanêmicos” aos “índios pindorâmicos”, vê-se nas suas telas, de fundo branco, a montagem de múltiplas temporalidades e espacialidades, pelo recurso da apropriação e deglutição, de outros pintores, de figuras históricas, de imagens da mídia, e até de si mesmo, o que produz uma mestiçagem de elementos compositivos. A presença de Glauco Rodrigues na BLA, no momento em que intelectuais, pensadores e críticos de arte da América Latina, num gesto de rejeição à dominação norte-americana e europeia, procuravam demonstrar as peculiaridades e potencialidades da arte da região, suscitou-nos a problemática desse artigo: o paradigma da antropofagia, que o artista aplica em sua arte, pode ser útil como ferramenta teórica para refletir sobre a cultura miscigenada que se produziu no Brasil. O argumento do artigo gira em torno do questionamento sobre a opção do Conselho de Arte e Cultura da Bienal pelo tema-título Mitos e Magia como fio condutor do evento que, aliado à forma de exposição, em sessões étnicas, renderam críticas; foram apontadas como razões que dificultaram a plena realização do certame. Glauco Rodrigues, no entanto, misturando os mitos, representou um dos grandes momentos da BLA.
Implementations of Artificial Intelligence in Various Domains of IT Governance: A Systematic Literature Review
Authors: Hariyanti Eva , Janeswari Made Balin , Moningka Malvin Mikhael , Aziz Fikri Maulana , Putri Annisa Rahma , Hapsari Oxy Setyo , Sutha Nyoman Agus Arya Dwija , Sinaga Yohannes Alexander Agusti , Bendesa Manik Prasanthi
Published: November 2023

Background: Artificial intelligence (AI) has become increasingly prevalent in various industries, including IT governance. By integrating AI into the governance environment, organizations can benefit from the consolidation of frameworks and best practices. However, the adoption of AI across different stages of the governance process is unevenly distributed.
Objective: The primary objective of this study is to perform a systematic literature review on applying artificial intelligence (AI) in IT governance processes, explicitly focusing on the Deming cycle. This study overlooks the specific details of the AI methods used in the various stages of IT governance processes.
Methods: The search approach acquires relevant papers from Elsevier, Emerald, Google Scholar, Springer, and IEEE Xplore. The obtained results were then filtered using predefined inclusion and exclusion criteria to ensure the selection of relevant studies.
Results: The search yielded 359 papers. Following our inclusion and exclusion criteria, we pinpointed 42 primary studies that discuss how AI is implemented in every domain of IT Governance related to the Deming cycle.
Conclusion: We found that AI implementation is more dominant in the plan, do, and check stages of the Deming cycle, with a particular emphasis on domains such as risk management, strategy alignment, and performance measurement since most AI applications are not able to perform well in different contexts as well as the other usage driven by its unique capabilities.
Keywords: Artificial Intelligence, Deming cycle, Governance, IT Governance domain, Systematic literature review
Analysis of Malaria Transmission Dynamics at Borobudur Health Center, Magelang Regency (Case Study 2021-2022)
Authors: Afnaniya Naila , Santjaka Aris , Bahri Bahri
Published: November 2023

Introduction: Magelang District received a malaria elimination certificate in 2014. No cases found at Borobudur Health Center since 2009 but in October 2021, there was a spike in the number of patients, with 38 instances spread across Giripurno Village, Giritengah Village, and Majaksingi Village. Therefore, it is necessary to study the dynamics of malaria transmission so that the methods of malaria transmission are known to prevent extraordinary malaria cases. Methods: This is qualitative research with a phenomenological approach. This study was conducted in 2023 by reviewing cases from 2021–2022. The respondents in this study included 38 people with malaria. This research uses descriptive analysis assisted by GIS applications to determine the distribution of malaria cases. Results and Discussion: Data processing results for 38 respondents in three villages revealed 23 index cases. Of the 23 cases, nine were within a radius of no more than 400 m and occurred within three days, thus including cluster classification. Theoretically, the same vector transmits it and has a high vectorial capacity. The other 15 patients were suspected to have secondary cases, with two transferred from the first case. The results of the breeding place survey or the potential breeding place after rearing revealed the species Anopheles balabacensis. Other predictors of malaria transmission are optimal temperature and humidity, environment, livestock places to rest mosquitoes, and patient behavior that causes a high frequency of mosquitoes biting humans. Conclusion: In this case, the transmission model was a cluster, and 100% of the cases were indigenous.
Spatial Map of Geohelminths Infection in Agricultural Communities and its Contamination in Soil of Jatian Village, Jember Regency
Authors: Yunita Armiyanti  , Nuramna Nanda , Afiful Jauhani Muhammad , Hermansyah Bagus , Utami Wiwien Sugih
Published: November 2023

Introduction: Geohelminth infections are a neglected global health problem. Data from the World Health Organization (WHO) in 2020 show that more than 24% of the world population is infected by geohelminths. The condition of the agricultural soil, which tends to be loose and moist, supports the development of the infective form of the geohelminth. This makes agricultural communities susceptible to geohelminth infections. This study aimed to determine a spatial map of geohelminth infection in agricultural communities and its contamination in the soil of Jatian Village, Jember Regency. Methods: This study used an observational analytical design and a spatial analysis approach. Sampling was performed using a random sampling method that included 43 samples. Data were obtained by examining soil and stool samples and the coordinates of the sampling locations. Data were analyzed using spatial analysis. Results and Discussion: The results of this study indicated that the prevalence of geohelminth infection in agricultural communities was 23.3%, and its contamination in the soil was 6.98%. Hookworms caused infections among respondents, and contamination in the ground was caused by Hookworms and Strongyloides stercoralis. Clustering analysis results showed that geohelminth infection formed two secondary clusters. Spatial autocorrelation and buffer analysis showed clustering of geohelminth infections within the buffer range (<100 m), indicating that the infection spreads more easily within the cluster. Conclusion: The spatial map showed the distribution pattern of clustered geohelminth infection cases and their contamination in soil within proximity, thereby increasing the risk of geohelminth transmission.
RELATIONSHIP BETWEEN EMPLOYEE ENGAGEMENT AND JOB SATISFACTION OF NURSES AT MUHAMMADIYAH BABAT LAMONGAN HOSPITAL
Authors: Meliana Ramadhani Alifia , Suratmi Suratmi , Hikmatul Qowi Nurul
Published: November 2023

Introduction: One of the problems that is prone to occur among nurses is job satisfaction. Good job satisfaction includes good relationships with fellow colleagues and the surrounding environment will create a friendly and good atmosphere so that a person feels comfortable and becomes attached to his work. The purpose of this research is to determine the relationship between employe engagement with the job satisfaction of nurses at the Muhammadiyah Babat General Hospital. Methods:The research used in this study was analytic correlation with a cross sectional approach using cluster sampling technique to get 48 respondents. This research used a closed questionnaire and analyzed using the Spearman test. Results: This study found that the results of employe engagement or employee engagement with nurses at Babat Lamongan General Hospital were mostly high, with 25 nurses (52.1%) and most of them had moderate job satisfaction with as many as 28 nurses (58.3). Conclusions:Based on the results of the analysis using the Spearman Rho test, it was found that the value of p = 0.000 (p <0.05) and the value of 𝑟 = 0.557, then H1 is accepted. This means that there is a relationship between Employe Engagement and Job Satisfaction of nurses at Muhammadiyah Babat General Hospital. Based on this research it is expected that nurses can increase their work productivity, as well as support each other and love their work more.
THE IMPACT OF SCHOOL WATCHING METHOD ON EARTHQUAKE DISASTER PREPAREDNESS ON PRIMARY SCHOOL STUDENTS AT SDN MOJOREJO 2 SRAGEN
Authors: Dewi Noorratri Erika , Mustika Sari Irma
Published: November 2023

Introduction: The world's largest archipelago, Indonesia is located on the equator between the plains of Asia and Australia and between the Pacific and Indian oceans. This geographical position can increase the danger of natural disasters such as tectonic earthquakes, volcanic eruptions, tsunamis, and so on. There are many consequences of eartquakes, on of which is that many buildings and destroyed or collapsed. School children can get involved in disaster preparedness at their schools because it is an effective, dynamic, and sustainable strategy that teaches kids to recognize the signs of disasters that happen around them from an early age. Disasters can occur anywhere, at any time, even in the middle of the school day. The aims of this study was determining the effect of the School Watching Method on earthquake disaster preparedness on Primary School Students, particularly at SDN Mojorejo 2 Sragen. Methods : The method employed was Quasy Experimental. The research design was a group pretest-posttest without control group design . there were 49 respondents and the sampiling used was total sampling. The research instrument used was a modified questionnaire from a questionnaire and a check sheet or preparedness observation from LIPI (S3) and UNESCO/ISDR. Results: The results of the dependents t test showed a p value of 0.0000, this meaning that there was a significant difference in average disaster preparedness after being given disaster education using the school watching method. Conclusions: The findings showed that there is an effect of the school watching method on earthquake disaster preparedness at SDN Mojorejo 2 Sragen.
HUSBAND'S SUPPORT WITH ADHERENCE TO THE INJECTION SCHEDULE FOR MOTHERS
Authors: Fadliyah Lailatul , Indra Puspitaningtyas Danty , Mardhika Amellia , Tyas Anestasia Pangestu Mei , Sulpat Emulliana , Sudaryanti Lestari
Published: November 2023

Introduction: Contraception is a method or tool used to prevent pregnancy. Injectable contraception is a type of hormonal contraceptive method. Contraceptive failure is the main source of unwanted pregnancies, failures can be caused by a lack of support from the closest people. The study aimed to determine the relationship between husband's support and adherence to repeat contraceptive injections by mothers. Methods: This research is analytic research with a cross-sectional design. The study population was 219 couples of childbearing age who were injectable contraceptive acceptors. The sample technique is purposive sampling, with a total sample of 40 couples of childbearing age. For data collection techniques researchers use a questionnaire. The analytical test used is the Chi Square Test. Results: Results showed that 28 respondents received high support from their husbands (70%), and 33 respondents adhered to repeat injection contraceptive visits (82.5%). Results of bivariate analysis with Chi Square obtained p value = 0.000. Conclusions: There is a relationship between husband's support and compliance with injection contraceptive repeat visits. Health education is needed for the husband and family to support regular repeat visits to minimize the occurrence of contraceptive failure.
İnsan bağırsak mikrobiyomunu COVID-19 için tedavi stratejileriyle ilişkilendiren mekanizmalar
Authors: AKIN Nihat , ÖZIŞIK Damla
Published: November 2023

Son zamanlardaki COVID-19 salgını, dünya çapında biyoloji, sosyal etkileşim ve halk sağlığının çehresini değiştirmiştir. Dünyada milyonlarca insan üzerinde yıkıcı bir etkisi oldu ve bunun sonucunda 2020-2021 peryodunda yaklaşık 18 milyonun üzerinde ölüme vakası olduğu tahmin edilmektedir. Ülkemizde bu rakam 100000’in üzerinde olarak belirtilmiştir. Ortaya çıkan kanıtlar, enfeksiyon ile bağırsak mikrobiyom durumu arasında bir bağlantı olduğunu öne sürdü. Bu, enfeksiyonun şiddetine katkıda bulunabilecek birkaç faktörden biridir. Bağırsakların bağışıklık, inflamatuar durum ve patojenlere meydan okuma yeteneği ile büyük ölçüde bağlantılı olduğu gerçeği göz önüne alındığında, viral sonuca potansiyel olarak meydan okumanın bir yolu olarak bağırsak mikrobiyotasının diyet müdahalesini düşünmeye değer. Bu bağlamda benzer solunum yolu enfeksiyonlarını azaltmak için probiyotikler ve prebiyotikler kullanılmıştır. Burada, bağırsak mikrobiyomu ve COVID-19 enfeksiyonu arasındaki bağlantıları özetliyoruz ve ayrıca probiyotik ve prebiyotik müdahalelerin etkili olabileceği mekanizmalar öneriyoruz.
Entre o texto, o palco e a tela: uma análise da trilha sonora de Ladrão em noite de chuva, de Reginaldo Carvalho
Authors: Silva Vladimir
Published: November 2023

Reginaldo Carvalho (Guarabira-PB, 1932 – João Pessoa-PB, 2013) compôs trilhas para teatro e cinema, tendo participado de diversas produções com diferentes grupos em vários estados. Com base em estudos anteriores (SILVA, 2017) e no catálogo de obras do compositor (CARVALHO, 1995), identificamos, até o momento, vinte e uma composições para espetáculos dramatúrgicos realizados entre 1947 e 1974. O objetivo desta investigação é analisar a trilha sonora de Ladrão em noite de chuva, de Millôr Fernandes, destacando seus principais elementos estruturais e o modo como ocorre a relação entre texto, música e imagem na narrativa fílmica. Trata-se, efetivamente, da única obra de que temos notícia, até hoje, que o compositor produziu para o cinema, daí a sua importância. Assim, procura-se contribuir com a expansão dos estudos neste campo e, mais especificamente, com a obra de Reginaldo Carvalho. O trabalho está dividido em duas etapas: a primeira dedica-se à descrição do enredo e aos principais aspectos da trilha; a segunda, à análise da relação entre texto, música e imagem, tomando como base Magaldi (2004), Duarte (2006), McKee (2006), Brait (2008), dentre outros. Nessa obra, percebe-se uma forte influência das experiências que o compositor vivenciou em Paris, durante a sua primeira temporada, entre 1953 e 1956. Nessa época, por meio do contato com Paul Le Flem, Olivier Messiaen e Pierre Schaeffer, ele participou de diversas atividades artístico-culturais e enveredou pelo campo do experimentalismo musical.
THE EFFECTIVENESS OF CHITOSAN NATURAL SOURCES ON PULP TISSUE REGENERATION
Authors: Ahmad Aisya Nadhifa , Ichrom Nahzi Muhammad Yanuar , Purwaningayu Juli Harnida
Published: November 2023

Background: Dental pulp plays a role in forming dentin, providing nutrition, and sensing harmful stimuli to the tooth. Pulp damage can occur due to physical, chemical, and biological factors. A regenerative therapy was developed so that the pulp can regenerate its tissue and the teeth can survive in the oral cavity with vital conditions. Tissue engineering is a principle developed in the treatment of pulp tissue regeneration. The main elements of tissue engineering are stem cells, scaffolds, and growth factors. Scaffolds are elements that support cell organization, migration, proliferation, differentiation, and vascularization. One example of a biomaterial that can be used as a scaffold is chitosan. Chitosan has been proved to be suitable as a biomedical material because it has several beneficial properties including increasing cell proliferation, attachment, and differentiation. Purpose: This study aims to determine the most effective natural ingredient chitosan for pulp tissue regeneration. Methods: This study used the literature review method with a narrative review procedure. The literature was searched using Google Scholar, Science Direct, ProQuest, and PubMed. Results: The results of the study from 6 articles showed that chitosan from shrimp, crab, and mushroom had the potential to increase pulp tissue regeneration in terms of 3 indicators (cell proliferation, attachment, and  differentiation). Conclusion: The most effective chitosan from natural sources for pulp regeneration is shrimp chitosan and mushroom chitosan. Keywords: Chitosan, Natural Sources, Pulp Tissue Regeneration
Fort Riley German POW stonework historic context and National Register of Historic Places (NRHP) evaluation
Authors: Schmidt Aaron , Schacht Kayley , Adams Sunny , Smith Adam
Published: November 2023

This project provides a historic context for the German prisoner-of-war (POW) experience at Fort Riley, Kansas, and an inventory of stonework features constructed using POW labor during World War II (WWII). The purpose of this historic context and inventory is to determine the stone-work’s eligibility for listing in the National Register of Historic Places (NRHP). Based on the historic context and inventory, researchers for this project have determined that there is a potential noncontiguous historic district at Fort Riley. This “German POW Stonework Historic District” at Fort Riley is composed of three linear segments: one concentrated around a stone drainage ditch at Camp Forsyth, one concentrated on a series of stone check dams at Camp Whitside, and one concentrated on a stone levee ditch and culvert at Camp Funston. Additionally, researchers have determined that 12 additional stonework features outside the proposed historic district boundaries are potentially eligible for the NRHP. These include a stone vehicular culvert at Camp Forsyth and four drainage gutters within Fort Riley’s main cantonment.
A Problem in Probabilistic Optimization
Authors: Bhandari Samir Kumar , Saha Parbati , Guria Shantanu , Choudhury Binayak S.
Published: November 2023

In our present discussion our target is to describe a method for determining the probabilistic distance between two sets. The approach here is through a construction of a non-self contraction from one set to the other and then seeking a global optimal approximate solution of the corresponding fixed point equation in probabilistic terms where the exact solution does not exist in general. The main theorem is illustrated with an example. The study is in the domain of probabilistic optimization.
Subgraph generation applied in GraphSAGE deal with imbalanced node classification
Authors: Huang Kai , Chen Chen
Published: November 2023

In graph neural network applications,GraphSAGE applies inductive learning and has been widely applied in important research topics such as node classification.The subgraph of nodes directly affects the classification performance for GraphSAGE due to it applies aggregation function to obtain embedding from the neighbors' feature.In many practical applications, the uneven class distribution of nodes makes it difficult for graph neural network to fully learn the topology and attribute of the minority, which limits the classification performance.Aiming at the problem of imbalanced node classification in GraphSAGE,we propose a new graph over-sampling algorithm called Subgraph Generation by Conditional Generative Adversarial Network (SG-CGAN).SG-CGAN learns the hidden layer expression of different nodes through GraphSAGEand trains conditional generative adversarial network(CGAN) through the nodes' hidden vector and related subgraph.Meanwhile, the hidden synthetic data is generated as input of CGAN to generate subgraphs of the minority,and retrain the GraphSAGE by adding the synthetic subgraphs.Experiments based on five graph datasets show that SG-CGAN can help GraphSAGE effectively improve ACC, macro-F1 and micro-F1,verifying the effectiveness of SG-CGAN generated data.
Unusual specific interaction of RBD with zeolite induces rapid neutralization of SARS-CoV-2
Authors: Fan Jie , Li Dan , Liu Shenxin , Zhu Miaojin , Zhang Tongtong , Yu Lisha , He Min , Chen Xutao , Wang Fangjun , Zhang Hang , Liu Zhuang , Shi Yifeng , Chen Hao , Zhang Wenzhao , Shi Chaojie , Weng Tianhao , Shi Danrong , Zou Shihui , Wang Qi , Chen Wei , Wu Nanping , YAO Hang-Ping , Xiao Liping
Published: November 2023

RBD-ACE2 interaction is critical in mediating SARS-CoV-2 attachment to its host cells. Blocking the attachment by inhibiting RBD-ACE2 binding is an effective way to prevent COVID-19 infection. In this study, we demonstrate that copper-ion exchanged zeolite (Cu-zeolite) binds specifically to RBD of SARS-CoV-2 via an unusual specific copper-content-dependent interaction of Cu-zeolite with RBD. Accordingly, Cu-zeolites prevent the virions from interacting with host cells, contributing to efficient and rapid SARS-CoV-2 neutralization. Therefore, Cu-zeolite has the potential to serve as a feasible and effective preventive measure to reduce exposure to the virus and as a therapeutic agent for post-exposure treatment of COVID-19.
Clinical, genetic profile and therapy evaluation of 11 Chinese paediatric patients with Fanconi-Bickel syndrome
Authors: Du Taozi , Xia Yu , Sun Chengkai , Gong Zhuwen , Liang Lili , Gong Zizhen , Wang Ruifang , Lu Deyun , Zhang Kaichuang , Yang Yi , Sun Yuning , Sun Manqing , Sun Yu , Xiao Bin , Qiu Wenjuan
Published: November 2023

Background: Fanconi-Bickel syndrome (FBS) is a rare autosomal recessive disorder characterized by impaired glucose and galactose utilization as well as proximal renal tubular dysfunction. Reported FBS data from China are scarce.
Methods: Clinical, biochemical, genetic, treatment, and follow-up data for 11 paediatric patients with FBS were retrospectively analysed.
Results: Hepatomegaly (10/11), short stature (10/11) and hypophosphataemic rickets (7/11) were the most common initial symptoms. At diagnosis, all patients had decreased fasting blood glucose (FBG), plasma bicarbonate (HCO3-) and serum phosphorus, as well as elevated liver transaminases, alkaline phosphatase (AKP) and proximal renal tubular dysfunction. Two infant patients were misdiagnosed with transient neonatal diabetes mellitus. After therapy with uncooked cornstarch and conventional rickets treatment, remission of hepatomegaly was observed in all patients, with significant improvements in FBG, liver transaminases, triglycerides, HCO3- and AKP (p < 0.05). At the last follow-up, 5/7 patients with elevated AKP had nephrocalcinosis. The mean height standard deviation score (Ht SDS) of eight patients with regular treatment increased from -4.1 to -3.5 (p = 0.02). Recombinant human growth hormone (rhGH) was administered to 4/9 patients, but their Ht SDS did not improve significantly (p = 0.13). Fourteen variants of the SLC2A2 gene were identified, with six being novel, among which one was recurrent: c.1217T>G (p.L406R) (allele frequency: 4/22, 18%). Patients with biallelic missense variants showed milder metabolic acidosis than those with null variants. Two of five patients from nonconsanguineous families with rare homozygous variations showed 5.3 Mb and 36.6 Mb of homozygosity surrounding the variants, respectively; a region of homozygosity (ROH) involving the entire chromosome 3 covering the SLC2A2 gene, suggesting uniparental disomy 3, was detected in one patient.
Conclusions: Early diagnosis of FBS is difficult due to the heterogeneity of initial symptoms. Although short stature is a major issue of treatment for FBS, rhGH is not recommended. Patients with biallelic null variants may require alkali supplementation since urine bicarbonate loss is genetically related. ROH is a mechanism for rare homozygous variants of FBS in nonconsanguineous families.
Ultrahigh-potent and broadly neutralizing anti-CD4 trimeric nanobodies inhibit HIV-1 infection by inducing CD4 conformational alteration
Authors: Wu Xilin , Zhu Linjing , Wang Xiangyao , Ni Fengfeng , Ao Mingjun , Wang Ruoke , Zheng Bin , Chen Chen , Shi Linen , Geng Shengya , Hu Jiaqian , Yang Mengshi , Zhang Doudou , Yang Ping , Li Miaomiao , Li Yuncheng , Hu Qinxue , Ye Sheng , Zheng Peng , Wei Hongxia , Zhang Linqi , Liu Yalan , Wu Zhiwei
Published: November 2023

Despite substantial progress in antiretroviral therapy (ART) effectively suppressing HIV-1 replication in the bloodstream, a cure for HIV remains elusive. Existing antiviral drugs pose limitations, including lifelong medication, frequent administration, side effects, and viral resistance, necessitating novel HIV-1 treatment approaches. CD4, the primary receptor for HIV-1 entry into host cells, was once a prime target for drug or vaccine development. However, challenges, such as the potency and breadth of neutralization and cytotoxicity associated with anti-CD4 antibodies, hindered progress. Nevertheless, Ibalizumab, the sole approved CD4-specific antibody for HIV-1 treatment, reignited interest in exploring alternative anti-HIV targets, emphasizing CD4's potential value for effective drug development. Here, we investigated anti-CD4 nanobodies, with a focus on Nb457 isolated from a human CD4-immunized alpaca. Nb457 displayed remarkable ultra-high potency and broad-spectrum activity against HIV-1, surpassing Ibalizumab's efficacy. Importantly, Nb457 showed no impact on CD4+ T cell function, akin to Ibalizumab. Strikingly, engineered trimeric Nb457 nanobodies, Nb457-NbHSA-Nb457, achieved 100% inhibition against live HIV-1, outperforming Ibalizumab and parental Nb457. Structural analysis revealed that Nb457 binding induced a CD4 conformational change, impeding viral entry. Molecular Dynamics simulations elucidated the structural basis for the complete inhibition of HIV-1 by Nb457-NbHSA-Nb457. Furthermore, Nb457 exhibited significant therapeutic efficacy against HIV-1 infection in humanized mouse models. In conclusion, our study highlights ultra-potent anti-CD4 nanobodies as a compelling source of new HIV-1 therapeutics. The development of Nb457-based drugs holds the potential to revolutionize clinical HIV-1 treatment, providing a powerful tool in the battle against this persistent global health challenge.
Measuring the equilibrium relationships among urbanization, output growth, and environmental quality in Nigeria
Authors: Posu Sunday Mauton Ayodamola , Adeniyi Ademola Israel , Olubiyi Ebenezer Adesoji , Ojo Olutunji Timothy , Obisanya Adesile Adesegun
Published: November 2023

This study investigates the long-run relationship and short-run dynamics among urbanization, output growth, and environmental quality in Nigeria. The study adopts autoregressive distributed lag, bounds test co-integration analysis and the autoregressive integrated moving average with the annual time series dataset for 1990-2021. A long-run equilibrium relationship among urbanization, output growth, and environmental quality is established. Urban population, output growth, per capita GDP, and population growth are all significantly related to CO2 emissions. The study confirms the Environmental Kuznets Curve (EKC) hypothesis on per capita GDP and CO2 emissions in Nigeria. The positive interactive effect of urban population and output growth reduces CO2 emissions just as an increase in per capita GDP in a previous period produces a short-run effect of reducing CO2 emissions. The first-period lagged change in per capita GDP reports a marginal statistically significant negative effect on current CO2 emissions. The study utilizes data on past CO2 emissions to predict how CO2 emissions might evolve in the coming years and to examine the environmental sustainability of Nigeria. The forecast of CO2 emissions for 2023-2030 are relatively stable with some marginal fluctuations, which confirm the validated EKC. To sustain the validated inverted U-shaped EKC and to avoid it assuming an N-shape in the future, this study recommends environmental policy focus to monitor the growth of large cities and to implement measures capable of mitigating CO2 emissions by decoupling economic growth from CO2 emissions; and by encouraging investment in clean energy sources, sustainable transportation, and industrial practices.
JEL Classification E23 . O44 . O33 . Q28 . Q56 . R11
Physical Mapping of Different Morphological Characters in Neurospora Crassa
Authors: Kanchan Kamni Kanchan , Vivek Vivek Anand , Rohit Rohit Kumar Verma
Published: November 2023

Neurospora crassa is a type of red bread mold fungi of the phylum Genus name, meaning “nerve spore” in Greek, refers to the characteristic striation on the spores. Neurospora crassa is use as a model organism because it is easy to grow and passed a haploid life cycle that makes genetic analysis of genetic recombination is facilitate by the ordered arrangement of the products of meiosis in Neurospora ascospores[1]. Orderly arrangement of tetrad is used in this present pieces of work to know the position of different morphological characters and also used for physical mapping of genes such as spore color, sporangium size, etc[2][3].
Mental Health Markers and Protective Factors in Students with Symptoms of Physical Pain across WEIRD and non-WEIRD Samples – a Network Analysis
Authors: Tandon Tanya , Piccolo Mayron , Ledermann Katharina , McNally Richard J. , Gupta Rashmi , Morina Naser , Martin-Soelch Chantal
Published: November 2023

More than 20% of youths experience a mental health disorder by the end of adolescence and 45% of the global burden of disease lies in the youth age range (18–25 years). These issues have now increased due to the stress of the COVID-19 pandemic especially among students. In addition to mental health issues, physical pain has become a major health problem among youth in general and university students in particular, with around 54% of them suffering from it each year worldwide. While research in non-Western, Educated, Industrialized, Rich, and Democratic (WEIRD) samples is less frequent, we recently reported a 45% prevalence of physical pain among university students in India. Prior studies conducted in Western societies identified that specific factors, i.e., posttraumatic stress disorder (PTSD), depression, anxiety, perceived stress, as well as protective factors like social support and self-efficacy have been associated with physical pain. Few studies have examined these factors across different cultures. Our study aimed to understand the relationship between specific mental health markers (i.e., depression, anxiety, PTSD, perceived stress) as well as specific protective factors (i.e., social support and self-efficacy) related to physical pain among university students and the possible differences and similarities across non-WEIRD and WEIRD samples in the interaction using network analysis which allows us to go beyond the traditional approaches and help us to understand which mental health marker might be particularly central to the experience of physical pain. No statistically significant difference was found between mental health markers (i.e., depression, anxiety, perceived stress, and PTSD) and protective factors (i.e., social support and self-efficacy) associated with physical pain symptoms for Swiss students versus Indian students (M = 0.325, p = .11). In addition, networks for Swiss versus Indian students did not differ in global strength (S = 0.29, p = .803). Interestingly, anxiety came to be the most central mental health marker, and social support was the most important protective factor related to physical pain in both countries. However, for Swiss students, perceived stress, and for Indian students, PTSD symptoms were central mental health markers related to physical pain. Also, these symptoms (and associations between symptoms) found in our study can contribute to the existing literature and keep in mind the existing cultural differences in the area of pain. Also, our study can be prioritized in theoretical models of physical pain and might also serve as important treatment targets for pain interventions among students before it becomes chronic in the future for both countries.
The importance of the Autostrain RV technique in the treatment of right ventricular myocardial alterations in patients with breast cancer receiving chemotherapy
Authors: Liang Yan , Song Yabo , Li Xinshi , Han Yingying , Dongye Hongfang , Zhao Can , Liu Hongqiang , Zhang Yue , Li Jinqiu
Published: November 2023

BACKGROUND
To research the value of Autostrain right ventricular(RV) technology in detecting and preventing right ventricular myocardial injury in patients undergoing breast cancer chemotherapy by providing an imaging basis for early identification.
METHODS
To examine the changes in various cardiac function parameters before and after chemotherapy, two-dimensional echocardiography was employed 48 h before chemotherapy, 48 h after the fourth cycle of chemotherapy, and 48 h after the eighth cycle of chemotherapy, respectively. The patients included those with breast cancer who underwent surgery and were primarily administered anthracycline-based chemotherapeutic drugs.
RESULTS
(1) Compared with the pre-chemotherapy period, the absolute values of the right ventricular global longitudinal strain (RV4CSL) and right ventricular free-wall longitudinal strain (RVFWSL) decreased after the fourth chemotherapy cycle, and no significant differences were observed in tricuspidannular plane systolic excursion (TAPSE), right ventricular Tei index, and right ventricular ejection fraction (RVEF); (2) Compared with the pre-chemotherapy period, the absolute values of RV4CSL and RVFWSL decreased after the eighth chemotherapy cycle. TAPSE decreased, the right ventricular Tei index increased, and no significant difference was observed in RVEF; (3) Compared with the end of the fourth chemotherapy cycle, the absolute values of RV4CSL and RVFWSL decreased at the end of the eighth chemotherapy cycle. TAPSE, right ventricular Tei index, and RVEF were not significantly different. (4) Pearson correlation analysis revealed a correlation between RV4CSL, RVFWSL, right ventricular Tei index, TAPSE, and RVEF.
CONCLUSION
RV4CSL and RVFWSL are sensitive indices that reflect changes in the right ventricular myocardium in the early stages of chemotherapy. They can reflect the effects of anthracycline on the right ventricular myocardium of patients with breast cancer earlier than the TAPSE and right ventricular Tei indices. In contrast, RVEF exhibits no significant changes during the early stages of right ventricular myocardial injury. A relationship exists between RVFWSL, RV4CSL, right ventricular Tei index, TAPSE, RVEF, and anthracycline-induced alterations in the right ventricular myocardium.This study is helpful for early detection of right ventricular myocardial function injury caused by anthracyclines in breast cancer patients, and provides imaging basis for early clinical detection and prevention of right ventricular myocardial injury.
A Peripheral Blood Transcriptomic Biomarker Panel Identified by Multiple Machine Learning Algorithms Enables Early Diagnosis and Prognosis Prediction in Lung Cancer
Authors: Li Xiaohua , Li Xuebing , Qin Jiangyue , Lei Lei , Guo Hua , Zheng Xi , Wen Fuqiang , Chen Jun
Published: November 2023

Background
Lung cancer is the leading cause of malignancy-associated mortality worldwide. Early-stage lung cancer often manifests without typical symptoms, frequently leading to late-stage diagnoses and grim prognoses. Therefore, the timely and precise identification of lung cancer in high-risk individuals is particularly significant. However, the development of machine learning-based models using peripheral blood-derived transcriptomic markers for early lung cancer detection remains unexplored.
Methods
Using a training cohort (GSE135304), we combined multiple machine learning algorithms to formulate the Lung Cancer Diagnostic Score (LCDS), utiliazing transcriptomic features within peripheral blood samples. To evaluate the LCDS model’s accuracy, we employed the area under the receiver operating characteristic (ROC) curve (AUC) in validation cohorts (GSE42834, GSE157086, and in-house dataset). Immune infiltration and pathway enrichment analyses were conducted to explore potential associations between the LCDS and lung cancer pathogenesis.
Results
Initial screening, based on univariable logistic regression in conjunction with ROC analysis, identified 844 genes. Subsequently, 87 genes, selected via Boruta features, were incorporated into 97 machine learning algorithms to construct the LCDS model. The highest accuracy was achieved using the random forest (RF) algorithm, incorporating expression of 87 genes, with a mean AUC value of 0.938. A lower LCDS was significantly associated with elevated immune scores, increased CD4 + T cells and CD8 + T cells. Furthermore, individuals within the higher LCDS group exhibited pronounced activation of hypoxia, PPAR, and Toll-like receptors (TLRs) signaling pathways, reduced DNA damage repair pathway scores.
Conclusions
An LCDS based on machine learning targeting transcriptomic features in peripheral blood was highly accurate in distinguishing lung cancer patients from healthy individuals. Additionally, individuals within the high LCDS group exhibited diminished antitumor immunity and augmented signaling pathway activity driving tumorigenesis and progression. The results of this study might facilitate the early lung cancer prediction and further promote precision treatment for lung cancer patients.