bluuebunny/crossref_metadata_2025 huggingface dataset:
Particle Reirradiation of Malignant Epithelial and Neuroectodermal Sinonasal Tumors: A Case Series from CNAO
Authors: Vischioni Barbara , Ingargiola Rossana , Bonora Maria , Ronchi Sara , Camarda Anna Maria , Russo Stefania , Rossi Eleonora , Magro Giuseppe , Mirandola Alfredo , Orlandi Ester
Published: March 2023

Sinonasal cancers (SNCs) are rare and heterogeneous in histology and biological behavior. The prognosis is generally unfavorable, especially in inoperable cases. In recent years, for some histologies, such as undifferentiated sinonasal carcinoma (SNUC), multimodal treatment with a combination of induction chemotherapy, surgery, and chemo/radiotherapy (RT) has improved the prognosis. Nevertheless, still about half of the patients treated incur a recurrence, in most of the cases at the local site. Surgery with and without RT is usually the treatment choice in cases of recurrence after previous RT in combination with systemic therapy or RT in a histology-driven fashion. In the case of inoperable disease or contraindications to surgery, RT is still a valid treatment option. In this context, hadron therapy with protons (PT) or carbon ions (CIRT) is often preferred due to the physical and biological characteristics of charged particles, allowing the administration of high doses to the tumor target while sparing the surrounding healthy tissues and potentially limiting the side effects due to the high cumulative dose. In the absence of a standard of care for the recurrent setting, we aimed to investigate the role of re-RT with PT or CIRT. We retrospectively analysed 15 patients with recurrent, previously irradiated, SNCs treated at our institution between 2013 and 2020. Local control (LC) and overall survival (OS) were estimated by the Kaplan–Meier method. Acute and late toxicities were scored according to the National Cancer Institute’s Common Terminology Criteria for Adverse Events CTCAE version 5.0. A total of 13 patients received CIRT and 2 patients received PT. The median re-RT dose was 54 GyRBE (range 45–64 GyRBE) delivered in 3 or 4 GyRBE/fr (fraction) for the CIRT, and 2 Gy RBE/fr for the PT schedule. LC was 44% at the 1-year follow-up and 35.2% at the 3-year follow-up. OS at 1 and 3 years were 92.9% and 38.2%, respectively. Fourteen patients developed G1–G2 acute toxicity (dermatitis and mucositis), and no patients developed G3–G5. Regarding late toxicity, 10 patients encountered at maximum G1–2 events, and 4 did not experience any toxicity. Only for one patient G3 late toxicity was reported (dysphagia requiring a percutaneous endoscopic gastrostomy).
Optimal Timing of Targeted Temperature Management for Post-Cardiac Arrest Syndrome: Is Sooner Better?
Authors: Wang I-Ting , Wang Chieh-Jen , Chen Chao-Hsien , Yang Sheng-Hsiung , Chen Chun-Yen , Huang Yen-Chun , Lin Chang-Yi , Wu Chien-Liang
Published: March 2023

Targeted temperature management (TTM) is often considered to improve post-cardiac arrest patients’ outcomes. However, the optimal timing to initiate cooling remained uncertain. This retrospective analysis enrolled all non-traumatic post-cardiac arrest adult patients with either out-of-hospital cardiac arrest (OHCA) or in-hospital cardiac arrest (IHCA) who received TTM from July 2015 to July 2021 at our hospital. The values of time delay before TTM and time to target temperature were divided into three periods according to optimal cut-off values identified using receiver operating characteristic curve analysis. A total of 177 patients were enrolled. A shorter time delay before TTM (pre-induction time) was associated with a lower survival chance at 28 days (32.00% vs. 54.00%, p = 0.0279). Patients with a longer cooling induction time (>440 minis) had better neurological outcomes (1.58% vs. 1.05%; p = 0.001) and survival at 28 days (58.06% vs. 29.25%; p = 0.006). After COX regression analysis, the influence of pre-induction time on survival became insignificant, but patients who cooled slowest still had a better chance of survival at 28 days. In conclusion, a shorter delay before TTM was not associated with better clinical outcomes. However, patients who took longer to reach the target temperature had better hospital survival and neurological outcomes than those who were cooled more rapidly. A further prospective study was warranted to evaluate the appropriate time window of TTM.
Care for Patients with Type-2 Chronic Rhinosinusitis
Authors: Giunta Gianmarco , Pirola Francesca , Giombi Francesco , Muci Giovanna , Pace Gian Marco , Heffler Enrico , Paoletti Giovanni , Puggioni Francesca , Cerasuolo Michele , Ferreli Fabio , Salamanca Fabrizio , Mercante Giuseppe , Spriano Giuseppe , Canonica Giorgio Walter , Malvezzi Luca
Published: March 2023

In the last 20 years, growing interest in chronic rhinosinusitis (CRS) has become evident in medical literature; nevertheless, it is still difficult to identify the real prevalence of the disease. Epidemiological studies are few and focused on heterogeneous populations and diagnostic methods. Recent research has contributed to identifying CRS as a disease characterized by heterogeneous clinical scenarios, high impact on quality of life, and elevated social costs. Patient stratification with phenotypes and identification of the pathobiological mechanism at the origin of the disease (endotype) and its comorbidities are pivotal in the diagnostic process, and they should be addressed in order to properly tailor treatment. A multidisciplinary approach, shared diagnostic and therapeutic data, and follow-up processes are therefore necessary. Oncological multidisciplinary boards offer models to imitate in accordance with the principles of precision medicine: tracing a diagnostic pathway with the purpose of identifying the patient’s immunological profile, monitoring therapeutical processes, abstaining from having only a single specialist involved in treatment, and placing the patient at the center of the therapeutic plan. Awareness and participation from the patient’s perspective are fundamental steps to optimize the clinical course, improve quality of life, and reduce the socioeconomic burden.
The Value of Ecosystem Traffic Noise Reduction Service Provided by Urban Green Belts: A Case Study of Shenzhen
Authors: Liu Li , Han Baolong , Tan Deming , Wu Dawei , Shu Chengji
Published: March 2023

With increasing urbanization in China, the traffic-induced urban environmental noise pollution problem is becoming more and more serious, and it has become a common urban malady that cannot be ignored. Traffic green belts are an important part of the urban ecosystem and play a role in traffic noise reduction, and simultaneously provide ecosystem services, such as creating a natural landscape and retaining dust. Therefore, they are a category of Nature-based Solutions (NbSs) that have multiple ecosystem service provisions. The relationship between NbSs and urban ecosystem services is one of the current research hot spots. However, regarding the assessment of ecosystem services on the urban scale, the role of vegetation in reducing noise pollution as a service has rarely been studied. Taking Shenzhen City as an example, through monitoring 217 sample plots in the city, this paper analyzes the relationship between vegetation coverage and the ability of green belts to reduce noise by using the IUEMS platform combined with the high-resolution spatial distribution data of green spaces. Then, we evaluated the product amount and the value of the roadside green belts in Shenzhen when acting as a noise reduction service. The work of this study, to a certain extent, improves the problems related to the inadequate consideration of vegetation characteristics in current urban-scale noise assessment models. The results show the following: (i) In the respective analysis buffer zones of the Grade I to Grade IV roads in Shenzhen, on average, for every 1% increase in the vegetation coverage of green belts, noise can be reduced by 0.4 dB, 1.0 dB, 0.2 dB, and 0.6 dB, respectively. (ii) The product value of the noise reduction service provided by roadside green belts is CNY 1.16 billion in Shenzhen. (iii) The road traffic noise greatly exceeds the standard in Shenzhen, but traffic noise can be decreased by increasing the vegetation coverage of green belts. This is not only beneficial to the scientific understanding of the ecological service value of green spaces by evaluating the noise reduction service of traffic green belts, as well as its influencing factors, but is also beneficial to making improvements in construction and management ideas for urban green spaces.
Land Use and Ecosystem Services Evolution in Danjiangkou Reservoir Area, China: Implications for Sustainable Management of National Projects
Authors: Liu Linghua , Zheng Liang , Wang Ying , Liu Chongchong , Zhang Bowen , Bi Yuzhe
Published: March 2023

The South-to-North Water Diversion Project (SNWDP) is one of the largest cross-basin and cross-region water transfer projects in the world. The Danjiangkou reservoir area, a haven of diverse species, serves as a core water source for the Central Line of the SNWDP. Yet, less research has been conducted on changes in land use and ecosystem services (ESs) in the Danjiangkou reservoir area in the context of the implementation of the SNWDP and other national projects. In this study, we aim to reveal evolutions of land uses and ESs in the Danjiangkou reservoir area and the response of ESs to natural and socio-economic factors. This is essential to enhance the regional sustainable management of the Danjiangkou reservoir area. Based on classified land use maps and the InVEST model, we first analyzed the land use changes and evaluated three typical types of ESs (i.e., water yield (WY), carbon storage (CS) and habitat quality (HQ)) in the Danjiangkou reservoir area during 2000 to 2018. Then, we detected the spatial clustering characteristics and tradeoffs and synergistic relationships of multiple ESs through hot spot analysis and correlation analysis. Finally, we adopt the geographical detector model (GDM) to identify key driving factors of ESs changes. The results show that: (1) During 2000–2018, the area of arable land and woodland decreased by 1.65% and 0.8%, respectively, while the proportion of construction land and water area increased by 1.31% and 1.39%, respectively. (2) The greatest decrease was in WY, decreasing by 59%, while the change in HQ was relatively stable, but showed spatial heterogeneity. (3) The northern, southern and western districts of the reservoir area showed mainly synergies among multiple ESs, while other regions showed mainly trade-offs. (4) Road network density, proportion of construction land and normalized difference vegetation index are the leading factors for ESs variations. These findings can provide reference for formulating more reasonable ecological protection strategies, so as to realize the sustainable management of SNWDP and its headwaters region.
People, Property and Territory: Valuation Perspectives and Economic Prospects for the Trazzera Regional Property Reuse in Sicily
Authors: Trovato Maria Rosa , Giuffrida Salvatore , Collesano Giuseppe , Nasca Ludovica , Gagliano Filippo
Published: March 2023

As in many parts of Italy and Europe, the Sicilian Trazzera regional property has been for a long time the main land infrastructure supporting the agro-pastoral economy. Throughout its slow evolution, this land heritage has been affected by transport transformations and illegal appropriations by neighboring landowners, which have reduced its potential public function in the current renewed prospects of sustainability and a new balance between territories concerning the issue of the inland areas. A further issue concerns the management of the relationship between private interest and prospects for public reuse in progressively urbanized territorial contexts where this infrastructure takes on considerable economic and real estate interest. The current regional legislation suggests some measures for inter-municipal planning that also include the legitimization of illegal appropriations. From this twofold prospect, according to the wide-spread information and communication technologies (ICTs), and also including the geographic information systems (GIS), this work provides the application of two assessment tools based on a GeoDatabase of the current heard roads in the two areas of quantitative–monetary and aesthetic–qualitative assessment. The first shows the extent to which the fair compensation to be charged for legitimizing land parcels is underestimated today, to the detriment of urban social fixed capital development. The second demonstrates the way that common awareness of landscape value can be nurtured for the benefit of land and ecological–environmental rebalancing.
Modern Industrial Heritage as Cultural Mediation in Urban Regeneration: A Case Study of Gunsan, Korea, and Taipei, Taiwan
Authors: Chung Hokyung , Lee Jongoh
Published: March 2023

Modern industrial heritage in East Asia shares the social and historical background of industrial and cultural products shaped during the colonial times around the 20th century—a period of political upheaval and rapid social transformation. Gunsan (Korea) and Taipei (Taiwan) share the historical characteristics of modern industrial facilities built during the Japanese colonial period. Moreover, these facilities are controversial and complex objects regarding which the notions of conservation of historical heritage and liquidation of colonial heritage coexist and are subjects of mediating the creation of modern cities in East Asia and transition to creative modern urbanization. The complexity surrounding these modern industrial facilities warrants an in-depth analysis of the methods of utilizing them as cultural heritage sites for cultural mediation, and Gunsan and Taipei are good examples for comparison. Here, we examined cultural urban regeneration utilizing modern industrial facilities formed from similar historical and social backgrounds in Taiwan and Korea. This is a comparative study of historical and cultural belts utilizing industrial buildings in Gunsan’s original city centre and Songshan Cultural and Creation Park in Taipei. Finally, we proposed implications for local residents, cultural communities rooted in the region, and user-centered cultural content for sustainable cultural urban regeneration.
The Effect of Urban Form on Urban Shrinkage—A Study of 293 Chinese Cities Using Geodetector
Authors: He Qingsong , Yan Miao , Zheng Linzi , Wang Bo , Zhou Jiang
Published: March 2023

Chinese cities are experiencing urban shrinkage due to demographic, environmental, economic, and political changes. However, urban form is another reason for urban shrinkage. This study first identified the shrinking of 293 cities in China based on the values of the change in brightness extracted from multi-year nighttime light data. Next, the characteristics of construction land morphology from 2019 were analyzed using landscape pattern analysis. Finally, the impact of urban form on urban shrinkage was explored using Geodetector. The results show that: (1) In total, 293 cities experienced different degrees of shrinkage. Regions with severe shrinkage were concentrated in the underdeveloped provinces, and autonomous central and western regions of China; moreover, (2) All factors of urban form significantly affected urban shrinkage. The largest q-values were found in patch density (0.144) and urban area (0.133), indicating that the degree of construction land fragmentation and urban area scale affected urban shrinkage the most; and (3) The interaction effects of pairwise factors were mutually or nonlinearly enhanced. The influence of urban form and socio-economic factors was stronger than that of socio-economic factors alone. This shows that the coupling of urban form and socio-economic factors strengthens the impact of urban form on urban shrinkage.
Synthesis and in Silico Investigation of Organoselenium-Clubbed Schiff Bases as Potential Mpro Inhibitors for the SARS-CoV-2 Replication
Authors: Shaaban Saad , Abdou Aly , Alhamzani Abdulrahman G. , Abou-Krisha Mortaga M. , Al-Qudah Mahmoud A. , Alaasar Mohamed , Youssef Ibrahim , Yousef Tarek A.
Published: March 2023

Since the first report of the organoselenium compound, ebselen, as a potent inhibitor of the SARS-CoV-2 Mpro main protease by Z. Jin et al. (Nature, 2020), different OSe analogs have been developed and evaluated for their anti-COVID-19 activities. Herein, organoselenium-clubbed Schiff bases were synthesized in good yields (up to 87%) and characterized using different spectroscopic techniques. Their geometries were studied by DFT using the B3LYP/6–311 (d, p) approach. Ten FDA-approved drugs targeting COVID-19 were used as model pharmacophores to interpret the binding requirements of COVID-19 inhibitors. The antiviral efficiency of the novel organoselenium compounds was assessed by molecular docking against the 6LU7 protein to investigate their possible interactions. Our results showed that the COVID-19 primary protease bound to organoselenium ligands with high binding energy scores ranging from −8.19 to −7.33 Kcal/mol for 4c and 4a to −6.10 to −6.20 Kcal/mol for 6b and 6a. Furthermore, the docking data showed that 4c and 4a are good Mpro inhibitors. Moreover, the drug-likeness studies, including Lipinski’s rule and ADMET properties, were also assessed. Interestingly, the organoselenium candidates manifested solid pharmacokinetic qualities in the ADMET studies. Overall, the results demonstrated that the organoselenium-based Schiff bases might serve as possible drugs for the COVID-19 epidemic.
Is the Benefit of Treating Iron Deficiency Greater in Acute Heart Failure with Renal Dysfunction?
Authors: López-Vilella Raquel , Guerrero Cervera Borja , Donoso Trenado Víctor , Sánchez-Lázaro Ignacio , Martínez Dolz Luis , Almenar Bonet Luis
Published: March 2023

Background: This study aims to analyse whether in acute heart failure (AHF) with iron deficiency (ID), the administration of ferric carboxymaltose (FCM) produces a greater benefit in renal dysfunction. Methods: A total of 812 consecutive patients admitted for AHF and ID were studied. Untreated (n:272) and treated (n:540) patients were compared. The six-month prevalence of a combined event (readmission for HF, all-cause death, and emergency department visit for decompensation) was analysed. Three grades of renal dysfunction (KDIGO) were compared, Group 1 (grades 1 and 2), Group 2 (grades 3a and 3b), and Group 3 (grades 4 and 5). Results: There were differences in sex distribution (untreated group: males 39.7% vs. treated group: males 51.9%; p < 0.001). Sex-adjusted combined event analysis showed a greater benefit in Group 1 (OR: 0.31, 95% CI:0.19–0.5; p < 0.001) and Group 2 (OR: 0.23, 95% CI:0.14–0.38; p < 0.001), but not in Group 3 (OR: 0.51, 95% CI:0.17–0.55; p: 0.237). Conclusions: The administration of FCM in patients with AHF and ID reduces the combined event analysed. The benefit is greater when renal dysfunction is present, except in very advanced degrees where no significant benefit is obtained.
Research on the Impact Mechanical Properties of Real-Time High-Temperature Granite and a Coupled Thermal–Mechanical Constitutive Model
Authors: Li Yubai , Zhai Yue , Xie Yifan , Meng Fandong
Published: March 2023

Studying the mechanical behavior of rocks under real-time high-temperature conditions is of great significance for the development of energy caverns, nuclear waste disposal projects, and tunneling engineering. In this study, a real-time high-temperature impact compression test was conducted on Sejila Mountain granite to explore the effects of temperature and external load on its mechanical properties. Based on the concepts of damage mechanics and statistics, a coupled thermal–mechanical (T-M) damage constitutive model was established, which considers the temperature effect and uses the double-shear unified strength as the yield criterion. The parameter expressions were clarified, and the accuracy and applicability of the model were verified by experimental data. The research results indicated that high temperatures had an obvious damaging and deteriorating effect on the strength of the granite, while an increase in impact velocity had an enhancing effect on the strength of the granite. The established constitutive model theoretical curve and test curve showed a high degree of agreement, indicating that the coupled T-M model can objectively represent the evolution process of damage in rocks and the physical meaning of its parameters is clear.
An Experimental and Numerical Analysis of Glued Laminated Beams Strengthened by Pre-Stressed Basalt Fibre-Reinforced Polymer Bars
Authors: Wdowiak-Postulak Agnieszka , Bahleda František , Prokop Jozef
Published: March 2023

Damage often develops in glued laminated timber members under high bending loads due to natural defects in the timber, which results in their low load-bearing capacity and stiffness. In order to improve the bending mechanical properties of glulam beams, a new type of longitudinal glulam reinforcement with pre-stressed basalt fibre-reinforced polymer composites (BFRP) was developed using the Near Surface Mounted (NSM) technique. The strengthening method consisted of two pre-stressed BFRP bars glued into the grooves at the bottom side of the beam; meanwhile, for the second strengthening alternative, the third BFRP bar was embedded into the groove at the top side of the beam. Therefore, an experimental study was carried out to verify this strengthening technique, in which fifteen full-size timber beams were tested with and without bonded BFRP bar reinforcement in three series. According to the results of this experimental study, it can be seen that the effective load-bearing capacity of the reinforced beams increased up to 36% and that the stiffness of the beams increased by 23% compared to the unreinforced beams. The tensile stresses in the wooden fibres were reduced by 11.32% and 25.42% on average for the beams reinforced with two and three BFRP bars, respectively. On the other hand, the compressive stresses were reduced by 16.53% and 32.10% compared to the unreinforced beams. The usual failure mode saw the cracking of the wood fibres at the defects, while for some specimens, there were also signs of cracks in the epoxy adhesive bond; however, the crack propagation was, overall, significantly reduced. The numerical calculations also show a good correlation with the experimental results. The difference in the results between the experimental and numerical analysis of the reinforced and unreinforced full-sized beams ranged between 3.63% and 11.45%.
Microstructure Evolution and Mechanical Properties of Al–Cu–Mg Alloys with Si Addition
Authors: Shah Abdul Wahid , Ha Seong-Ho , Siddique Jabir Ali , Kim Bong-Hwan , Yoon Young-Ok , Lim Hyun-Kyu , Kim Shae K.
Published: March 2023

The aim of this study was to investigate the impact of the addition of a minor quantity of Si on the microstructure evolution, heat treatment response, and mechanical properties of the Al–4.5Cu–0.15Ti–3.0Mg alloy. The microstructure analysis of the base alloy revealed the presence of α-Al grains, eutectic α-Al-Al2CuMg (S) phases, and Mg32(Al, Cu)49 (T) phases within the Al grains. In contrast, the Si-added alloy featured the eutectic α-Al-Mg2Si phases, eutectic α-Al-S-Mg2Si, and Ti-Si-based intermetallic compounds in addition to the aforementioned phases. The study found that the Si-added alloy had a greater quantity of T phase in comparison to the base alloy, which was attributed to the promotion of T phase precipitation facilitated by the inclusion of Si. Additionally, Si facilitated the formation of S phase during aging treatment, thereby accelerating the precipitation-hardening response of the Si-added alloy. The as-cast temper of the base alloy displayed a yield strength of roughly 153 MPa, which increased to 170 MPa in the Si-added alloy. As a result of the aging treatment, both alloys exhibited a notable increase in tensile strength, which was ascribed to the precipitation of S phases. In the T6 temper, the base alloy exhibited a yield strength of 270 MPa, while the Si-added alloy exhibited a significantly higher yield strength of 324 MPa. This novel Si-added alloy demonstrated superior tensile properties compared to many commercially available high-Mg-added Al–Cu–Mg alloys, making it a potential replacement for such alloys in various applications within the aerospace and automotive industries.
Scanning Algorithm Optimization for Achieving Low-Roughness Surfaces Using Ultrashort Laser Pulses: A Comparative Study
Authors: Kažukauskas Evaldas , Butkus Simas , Jukna Vytautas , Paipulas Domas , Sirutkaitis Valdas
Published: March 2023

Femtosecond laser-assisted material surface modification is a rapidly growing field with numerous applications, including tribology, micromechanics, optofluidics, and medical implant treatment. For many of these applications, precise control of surface roughness after laser treatment is crucial, as it directly affects the final properties of the work surface. However, achieving low mean surface roughness values (<100 nm) is challenging due to the fundamental principles of laser light–matter interactions. The complex physical processes that occur during laser material interactions make it difficult to achieve the desired surface roughness, and only advanced scanning methods can potentially solve this issue. In our study, we analyzed laser scanning algorithms to determine the optimal method for producing surfaces with minimal roughness. We investigated how scanning parameters such as the overlap of modifications, the amount of successive line shift, and laser-scanner synchronization impact surface roughness. Using a numerical model, we obtained results that showed good agreement with experimentally acquired data. Our detailed theoretical and experimental analysis of different scanning methods can provide valuable information for the future optimization of minimal-roughness micromachining.
Reinforcement Corrosion in RC Hollow Piers: Destructive and Non-Destructive Tests
Authors: Lignola Gian Piero , Fabbrocino Francesco , Prota Andrea , Cosenza Edoardo , Manfredi Gaetano
Published: March 2023

In this work, cyclic-load tests on reduced-scale corroded reinforced-concrete hollow cross-section bridge piers have been experimentally performed and compared to the results of similar non-corroded piers. Piers were aged by using an imposed electric current and sodium chloride water solution before performing a mechanical cyclic-load test. The corrosion process has been detected with Non-Destructive Evaluation techniques by means of SonReb method (to check concrete degradation) and by measuring corrosion potential (to check steel degradation). The crack pattern was recorded by dedicated cameras, and an LVDT system was set up to monitor the cyclic-load test. Experimental results focused on degradation monitoring and mechanical performance under cyclic loads. During the cyclic-load mechanical test, the first cracks on the piers surface occurred diagonally, inclined at about 45°. This is the consequence of the failure mode change from ductile failure, as expected for slender designed piers, to brittle shear failure. The flexural failure occurred in the case of non-corroded piers. Presented tests can provide a useful contribution of experimental data to analyse the behaviour of corroded reinforced concrete hollow bridge piers, scarcely tested. In particular, the cyclic response can be a useful reference for the proposition/validation of nonlinear capacity models for the evaluation of the seismic capacity of corroded bridge piers.
Hydrogen Dissociation Reaction on First-Row Transition Metal Doped Nanobelts
Authors: Bayach Imene , Sarfaraz Sehrish , Sheikh Nadeem S. , Alamer Kawther , Almutlaq Nadiah , Ayub Khurshid
Published: March 2023

Zigzag molecular nanobelts have recently captured the interest of scientists because of their appealing aesthetic structures, intriguing chemical reactivities, and tantalizing features. In the current study, first-row transition metals supported on an H6-N3-belt[6]arene nanobelt are investigated for the electrocatalytic properties of these complexes for the hydrogen dissociation reaction (HDR). The interaction of the doped transition metal atom with the nanobelt is evaluated through interaction energy analysis, which reveals the significant thermodynamic stability of TM-doped nanobelt complexes. Electronic properties such as frontier molecular orbitals and natural bond orbitals analyses are also computed, to estimate the electronic perturbation upon doping. The highest reduction in the HOMO–LUMO energy gap compared to the bare nanobelt is seen in the case of the Zn@NB catalyst (4.76 eV). Furthermore, for the HDR reaction, the Sc@NB catalyst displays the best catalytic activity among the studied catalysts, with a hydrogen dissociation barrier of 0.13 eV, whereas the second-best catalytic activity is observed for the Zn@NB catalyst (0.36 eV). It is further found that multiple active sites, i.e., the presence of the metal atom and nitrogen atom moiety, help to facilitate the dissociation of the hydrogen molecule. These key findings of this study enhance the understanding of the relative stability, electronic features, and catalytic bindings of various TM@NB catalysts.
Hall–Petch Description of the Necking Point Stress
Authors: Vinogradov Alexey , Estrin Yuri
Published: March 2023

We posited that the grain size dependence of the tensile necking stress, as determined by the Considère criterion for plastic instability, is a more meaningful characteristic of the Hall–Petch (H–P) effect than that of the yield stress or the 0.2% proof stress. An inverse square-root dependence of the necking stress on the grain size was derived from a dislocation dynamics-based constitutive model. In this model, the grain size effect enters the stress indirectly via the evolution of the dislocation density. Model predictions were confirmed by the experimental data for nickel and titanium.
An Experimental and Computational Analysis of Plant Compounds from Whole Urtica dioica L. Plant’s Essential Oil for Antioxidant and Antibacterial Activities
Authors: Khan Muhammad Zahid , Azad Abul Kalam , Jan Saleem , Safdar Muhammad , Bibi Shabana , Majid Amin Malik Shah Abdul , Albadrani Ghadeer M. , Nouh Nehal Ahmed Talaat , Abdulhakim Jawaher A. , Abdel-Daim Mohamed M.
Published: March 2023

As the Urtica dioica L. whole plant’s essential oil has presented significant multiple activities, it was therefore evaluated using the GC–MS technique. This essential oil was investigated for its antioxidant, phytotoxic, and antibacterial activities in vitro. The GC–MS analysis data assisted in the identification of various constituents. The study of the essential oil of U. dioica showed potential antioxidant effects and antibacterial activity against the selected pathogens Escherichia coli -ATCC 9837 (E. coli), Bacillus subtilis-ATCC 6633 (B. subtilis), Staphylococcus aureus-ATCC6538 (S. aureus), Pseudomonas aeruginosa-ATCC 9027 (P. aeruginosa), and Salmonella typhi-ATCC 6539 (S. typhi). The library of 23 phytochemicals was docked by using MOE software, and three top virtual hits with peroxiredoxin protein [PDB ID: 1HD2] and potential target protein [PDB ID: 4TZK] were used; hence, the protein–ligand docking results estimated the best binding conformations and a significant correlation with the experimental analysis, in terms of the docking score and binding interactions with the key residues of the native active binding site. The essential oil in the silico pharmacokinetic profile explained the structure and activity relationships of the selected best hits, and their additional parameters provided insight for further clinical investigations. Therefore, it is concluded that the U. dioica essential oil could be a potent antioxidant and antibacterial agent for aromatherapy through its topical application, if further tested in a laboratory and validated.
Analysis of Floral Scent and Volatile Profiles of Different Aster Species by E-nose and HS-SPME-GC-MS
Authors: Song Seung-Yeop , Ahn Myung-Suk , Mekapogu Manjulatha , Jung Jae-A , Song Hyun-Young , Lim So-Hyeon , Jin Jong-Sik , Kwon Oh-Keun
Published: March 2023

Plants from the Aster species are known to be a rich source of bioactive chemical compositions and are popularly known for their medicinal properties. To investigate the relationship between the nine species of Aster, the floral fragrance and volatile profile patterns were characterized using E-nose and HS-SPME-GC-MS. Initial optimization for fragrance analysis was performed with Aster yomena using E-nose by evaluating the scent patterns in different flowering stages. Aster yomena exhibited varied scent patterns in each flowering stage, with the highest relative aroma intensity (RAI) in the full flowering stage. PCA analysis to compare and analyze the scent characteristics of nine Aster species, showed a species-specific classification. HS-SPME-GC-MS analysis of flowers from nine Aster species revealed 52 volatile compounds including β-myrcene, α-phellandrene, D-limonene, trans-β-ocimene, caryophyllene, and β-cadinene. The terpenoid compounds accounted for the largest proportion. Among the nine Aster species flowers, Aster koraiensis had sesquiterpenes as the major component, and the remaining eight varieties had monoterpenes in abundance. These results could distinguish the species according to the scent patterns and volatile components of the nine Aster species. Additionally, flower extracts from the Aster species’ plants exhibited radical scavenging antioxidant activity. Among them, it was confirmed that Aster pseudoglehnii, Aster maackii, and Aster arenarius had high antioxidant activity. In conclusion, the results of this study provide fundamental data of the volatile compound properties and antioxidant activity of Aster species, offering basic information of valuable natural sources that can be utilized in the pharmaceutical, perfume, and cosmetic industries.
A Four Element mm-Wave MIMO Antenna System with Wide-Band and High Isolation Characteristics for 5G Applications
Authors: Munir Mehr E , Kiani Saad Hassan , Savci Huseyin Serif , Marey Mohamed , Khan Jehanzeb , Mostafa Hala , Parchin Naser Ojaroudi
Published: March 2023

In this article, we propose a light weight, low profile Multiple Input Multiple Output (MIMO) antenna system for compact 5th Generation (5G) mmwave devices. Using a RO5880 substrate that is incredibly thin, the suggested antenna is made up of circular rings stacked vertically and horizontally on top of one another. The single element antenna board has dimensions of 12 × 12 × 0.254 mm3 while the size of the radiating element is 6 × 2 × 0.254 mm3 (0.56λ0 × 0.19λ0 × 0.02λ0). The proposed antenna showed dual band characteristics. The first resonance showed a bandwidth of 10 GHz with a starting frequency of 23 GHz to an ending frequency point of 33 GHz followed by a second resonance bandwidth of 3.25 GHz ranging from 37.75 to 41 GHz, respectively. The proposed antenna is transformed into a four element Linear array system with size of 48 × 12 × 0.254 mm3 (4.48λ0 × 1.12λ0 × 0.02λ0). The isolation levels at both resonance bands were noted to be >20 dB which shows high levels of isolation among radiating elements. The MIMO parameters such as Envelope Correlation Co-efficient (ECC), Mean Effective Gain (MEG) and Diversity Gain (DG) were derived and were found to be in satisfactory limits. The proposed MIMO system model is fabricated and through validation and testing of the prototype, the results were found to be in good agreement with simulations.
Modeling and Compensation of Positioning Error in Micromanipulation
Authors: Hao Miao , Yang Bin , Ru Changhai , Yue Chunfeng , Huang Zongjie , Zhai Rongan , Sun Yu , Wang Yong , Dai Changsheng
Published: March 2023

In order to improve the positioning accuracy of the micromanipulation system, a comprehensive error model is first established to take into account the microscope nonlinear imaging distortion, camera installation error, and the mechanical displacement error of the motorized stage. A novel error compensation method is then proposed with distortion compensation coefficients obtained by the Levenberg–Marquardt optimization algorithm combined with the deduced nonlinear imaging model. The compensation coefficients for camera installation error and mechanical displacement error are derived from the rigid-body translation technique and image stitching algorithm. To validate the error compensation model, single shot and cumulative error tests were designed. The experimental results show that after the error compensation, the displacement errors were controlled within 0.25 μm when moving in a single direction and within 0.02 μm per 1000 μm when moving in multiple directions.
Novel SiGe/Si Heterojunction Double-Gate Tunneling FETs with a Heterogate Dielectric for High Performance
Authors: Chen Qing , Sun Rong , Miao Ruixia , Liu Hanxiao , Yang Lulu , Qi Zengwei , He Wei , Li Jianwei
Published: March 2023

In this paper, a new SiGe/Si heterojunction double-gate heterogate dielectric tunneling field-effect transistor with an auxiliary tunneling barrier layer (HJ-HD-P-DGTFET) is proposed and investigated using TCAD tools. SiGe material has a smaller band gap than Si, so a heterojunction with SiGe(source)/Si(channel) can result in a smaller tunneling distance, which is very helpful in boosting the tunneling rate. The gate dielectric near the drain region consists of low-k SiO2 to weaken the gate control of the channel-drain tunneling junction and reduce the ambipolar current (Iamb). In contrast, the gate dielectric near the source region consists of high-k HfO2 to increase the on-state current (Ion) through the method of gate control. To further increase Ion, an n+-doped auxiliary tunneling barrier layer (pocket)is used to reduce the tunneling distance. Therefore, the proposed HJ-HD-P-DGTFET can obtain a higher on-state current and suppressed ambipolar effect. The simulation results show that a large Ion of 7.79 × 10−5 A/μm, a suppressed Ioff of 8.16 × 10−18 A/μm, minimum subthreshold swing (SSmin) of 19 mV/dec, a cutoff frequency (fT) of 19.95 GHz, and gain bandwidth product (GBW) of 2.07 GHz can be achieved. The data indicate that HJ-HD-P-DGTFET is a promising device for low-power-consumption radio frequency applications.
Film-Shaped Self-Powered Electro-Osmotic Micropump Array
Authors: Yamanaka Toshiro , Arai Fumihito
Published: March 2023

This paper reports a new concept of a film-shaped micropump array for biomedical perfusion. The detailed concept, design, fabrication process, and performance evaluation using prototypes are described. In this micropump array, an open circuit potential (OCP) is generated by a planar biofuel cell (BFC), which in turn generates electro-osmotic flows (EOFs) in multiple through-holes arranged perpendicular to the micropump plane. The micropump array is thin and wireless, so it can be cut like postage stamps, easily installed in any small location, and can act as a planar micropump in solutions containing the biofuels glucose and oxygen. Perfusion at local sites are difficult with conventional techniques using multiple separate components such as micropumps and energy sources. This micropump array is expected to be applied to the perfusion of biological fluids in small locations near or inside cultured cells, cultured tissues, living organisms, and so on.
Simulations of the Rotor-Stator-Cavity Flow in Liquid-Floating Rotor Micro Gyroscope
Authors: Wang Chunze , Feng Rui , Chu Yao , Tan Qing , Xing Chaoyang , Tang Fei
Published: March 2023

When rotating at a high speed in a microscale flow field in confined spaces, rotors are subject to a complex flow due to the joint effect of the centrifugal force, hindering of the stationary cavity and the scale effect. In this paper, a rotor-stator-cavity (RSC) microscale flow field simulation model of liquid-floating rotor micro gyroscopes is built, which can be used to study the flow characteristics of fluids in confined spaces with different Reynolds numbers (Re) and gap-to-diameter ratios. The Reynolds stress model (RSM) is applied to solve the Reynolds averaged Navier–Stokes equation for the distribution laws of the mean flow, turbulence statistics and frictional resistance under different working conditions. The results show that as the Re increases, the rotational boundary layer gradually separates from the stationary boundary layer, and the local Re mainly affects the distribution of velocity at the stationary boundary, while the gap-to-diameter ratio mainly affects the distribution of velocity at the rotational boundary. The Reynolds stress is mainly distributed in boundary layers, and the Reynolds normal stress is slightly greater than the Reynolds shear stress. The turbulence is in the state of plane-strain limit. As the Re increases, the frictional resistance coefficient increases. When Re is within 104, the frictional resistance coefficient increases as the gap-to-diameter ratio decreases, while the frictional resistance coefficient drops to the minimum when the Re exceeds 105 and the gap-to-diameter ratio is 0.027. This study can enable a better understanding of the flow characteristics of microscale RSCs under different working conditions.
FOSS-Based Method for Thin-Walled Structure Deformation Perception and Shape Reconstruction
Authors: Wu Huifeng , Dong Rui , Xu Qiwei , Liu Zheng , Liang Lei
Published: March 2023

To improve the accuracy of deformation perception and shape reconstruction of flexible thin-walled structures, this paper proposes a method based on the combination of FOSS (fiber optic sensor system) and machine learning. In this method, the sample collection of strain measurement and deformation change at each measuring point of the flexible thin-walled structure was completed by ANSYS finite element analysis. The outliers were removed by the OCSVM (one-class support vector machine) model, and the unique mapping relationship between the strain value and the deformation variables (three directions of x-, y-, and z-axis) at each point was completed by a neural-network model. The test results show that the maximum error of the measuring point in the direction of the three coordinate axes: the x-axis is 2.01%, the y-axis is 29.49%, and the z-axis is 15.52%. The error of the coordinates in the y and z directions was large, and the deformation variables were small, the reconstructed shape had good consistency with the deformation state of the specimen under the existing test environment. This method provides a new idea with high accuracy for real-time monitoring and shape reconstruction of flexible thin-walled structures such as wings, helicopter blades, and solar panels.
Early Dirty Buffer Flush with Second Chance for SSDs
Authors: Shin Ilhoon
Published: March 2023

As high-performance server-based applications become more prevalent, there is a growing demand for high-performance storage solutions. In response, SSDs that use NAND flash memory as storage media are quickly replacing hard disks in the high-performance storage market. One way to improve SSD performance is to use an internal large-capacity memory as a buffer cache for NAND. Previous studies have shown that early flushing, which ensures sufficient clean buffers by flushing dirty buffers to NAND in advance when the ratio of dirty buffers exceeds a threshold, significantly reduces the average response time of I/O requests. However, the early flush can also have a negative side effect, namely an increase in NAND write operations. To address this problem, this study proposes a selective early flush policy. This policy evaluates the likelihood of a candidate dirty buffer being rewritten upon the early flush, and delays flushing if the candidate has a high rewrite likelihood. Through this selective early flush, the proposed policy reduces NAND write operations by up to 18.0% compared to the existing early flush policy in the mixed trace. Additionally, the response time of I/O requests is also improved in most of the considered configurations.
An Aluminum Electro-Thermally Actuated Micro-Tweezer: Manufacturing and Characterization
Authors: Voicu Rodica-Cristina , Tibeica Catalin
Published: March 2023

In this paper, we present the investigations of an aluminum micro-tweezer designed for micromanipulation applications. It includes design, simulation, fabrication, characterizations, and experimental measurements. Electro-thermo-mechanical FEM-based simulations using COMSOL Multiphysics were performed to describe the behavior of the micro-electro-mechanical system (MEMS) device. The micro-tweezers were fabricated in aluminum, as structural material, by surface micromachining processes. Experimental measurements were performed and compared with the simulation results. A micromanipulation experiment was performed using titanium microbeads from 10–30 µm to confirm the performance of the micro-tweezer. This study serves as further research regarding the using of aluminum as structural material for MEMS devices designated for pick-and-place operations.
Schiff Base Compounds as Fluorescent Probes for the Highly Sensitive and Selective Detection of Al3+ Ions
Authors: Pang Yanling , Meng Desu , Liu Jian , Duan Shengxia , Fan Jingru , Gao Longyu , Long Xinshu
Published: March 2023

Two new Schiff base fluorescent probes (L and S) were designed for selectively detecting Al3+ ions in aqueous medium. Structural characterization of the purely synthesized compounds was acquired by IR, 1H NMR and 13C NMR. Moreover, their photochromic and fluorescent behaviors have been investigated systematically by UV–Vis absorption and fluorescence spectra. The two probes have both high selectivity and sensitivity toward Al3+ ions in aqueous medium. The 2:1 stoichiometry between the Al3+ and probes was verified by Job’s plot. Moreover, the limits of detection (LOD) for Al3+ by L and S were 1.98 × 10−8 and 4.79 × 10−8 mol/L, respectively, which was much lower than most previously reported probes. The possible recognition mechanism was that the metal ions would complex with Schiff base probes because of the prevalence of the species optimal for complex formation, inhibiting the structural isomerization of conjugated double bonds (-C=N-), inhibiting the proton transfer process in the excited state of the molecules and resulting in changes of its color and fluorescence behavior. Furthermore, the probes will have potential applications for selectively, detecting Al3+ ions in the environmental system with high accuracy and providing a new strategy for the design and synthesis of multi-functional sensors.
Multi-Dimensional Antioxidant Screening of Selected Australian Native Plants and Putative Annotation of Active Compounds
Authors: Ghani Md. , Barril Celia , Bedgood Danny , Burrows Geoffrey , Ryan Danielle , Prenzler Paul
Published: March 2023

Acacia implexa, Eucalyptus rossii and Exocarpos cupressiformis are native plants of Australia, which were used by the First Peoples for medicinal purposes. In this study, 70% aqueous ethanol crude extracts were prepared from A. implexa bark and leaves, E. rossii leaves and E. cupressiformis leaves, and partitioned via sequential extraction with n-hexane, dichloromethane (DCM), ethyl acetate and ethanol. The crude extracts and fractions were screened for antioxidant activity using a novel, high-throughput lipid-based antioxidant assay, as well as the aqueous ABTS (2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)) assay and the Folin–Ciocalteu test for total phenols. In the lipid-based assay, non-polar n-hexane and DCM fractions showed higher antioxidant activity against the formation of peroxides and thiobarbituric acid reactive substances (TBARS) than the other fractions, whereas the non-polar fractions were not effective in aqueous assays. This illustrates that the high potential of the lipid-soluble n-hexane and DCM fractions as antioxidants would have been missed if only aqueous-based assays were used. In addition, the potent antioxidant compounds were putatively annotated using liquid chromatography quadrupole time-of-flight mass spectrometry (LC-qTOF-MS). Gallic acid, (+)-catechin, (−)-epicatechin and tannins were found in most crude extracts.