bluuebunny/crossref_metadata_2025 huggingface dataset:
Uncovering the Potential for the Sustainable Commercialization of Non-Timber Forest Products: Palm Fruits in Pando, Bolivia
Authors: Arancibia Alfaro Andrea V. , Schunko Christoph , Callo-Concha Daniel
Published: May 2024

Palm fruits are important non-timber forest products for rural people's livelihoods in the Amazon region, as many are nutritious foods and have the potential to generate income. However, in Pando, Bolivia, their commercialization is in most cases still underdeveloped. This study aimed to assess the potential of four palm fruits for sustainable commercialization and to identify their related promoting and hindering conditions. The palm fruits studied were açaí (Euterpe precatoria Mart), majo (Oenocarpus bataua Mart), motacu (Attalea phalerata Mart. ex Spreng) and palma real (Mauritia flexuosa L.f.). We gathered data from 14 key informants using semi-structured online interviews, 10 community members using structured interviews, and literature. We analyzed the data with qualitative content analysis and a multi-criteria decision-making method. Açaí has the highest potential due to its high abundance, demand, and specialized institutional support, among others. Majo, with a medium potential, benefited from its similarities with açaí regarding harvesting and processing, but still has technical processing deficiencies. Palma real and motacu had low potential because of low demand and lack of knowledge regarding harvesting and processing. This study demonstrates the importance of considering multidisciplinary factors when assessing sustainable commercialization potentials.
Emerging Pro-neurogenic Therapeutic Strategies for Neurodegenerative Diseases: A Review of Pre-clinical and Clinical Research
Authors: Vassal Mariana , Martins Filipa , Monteiro Bruno , Tambaro Simone , Martinez-Murillo Ricardo , Rebelo Sandra
Published: May 2024

The neuroscience community has largely accepted the notion that functional neurons can be generated from neural stem cells in the adult brain, especially in two brain regions: the subventricular zone of the lateral ventricles and the subgranular zone in the dentate gyrus of the hippocampus. However, impaired neurogenesis has been observed in some neurodegenerative diseases, particularly in Alzheimer’s, Parkinson’s, and Huntington’s diseases, and also in Lewy Body dementia. Therefore, restoration of neurogenic function in neurodegenerative diseases emerges as a potential therapeutic strategy to counteract, or at least delay, disease progression. Considering this, the present study summarizes the different neuronal niches, provides a collection of the therapeutic potential of different pro-neurogenic strategies in pre-clinical and clinical research, providing details about their possible modes of action, to guide future research and clinical practice.
Validation of the moral foundations questionnaire-2 in the Turkish context: exploring its relationship with moral behavior
Authors: Dogruyol Burak , Velioglu İlayda , Bayrak Fatih , Acem Ensar , Isler Ozan , Yilmaz Onurcan
Published: May 2024

Despite the considerable attention it has received, Moral Foundations Theory (MFT) remains open to criticisms regarding failure to conceptualize the moral domain. MFT was revised in response to these criticisms, along with its measurement tool, the Moral Foundations Questionnaire (MFQ-2). However, the validity of this revised theoretical structure and its explanatory power relative to existing alternatives, such as Morality as Cooperation Theory (MAC), has not yet been independently tested. Here we first validated MFT’s revised six-factor structure using the MFQ-2 in a large quasi-representative sample (N = 1099) from a predominantly Muslim country (i.e., Türkiye) and then explored the relationship of these six factors with incentivized measures of moral behavior as well as different psychological variables. Our tests revealed excellent fit values for the six-factor structure proposed by the MFQ-2, which explained more of the variance in criterion variables compared to the MAC Questionnaire (MAC-Q). However, MAC-Q performed better in predicting actual moral behavior (e.g., generosity and cooperation) compared with MFQ-2. Taken together, these findings indicate that, at least for the time being, MFQ-2 and the structure of the moral foundations proposed by MFT can be used to conceptualize the moral domain, but its relatively weak relationship to actual moral behavior limits its insights.
A Sharp Estimate for the Genus of Embedded Surfaces in the 3-Sphere
Authors: Kwong Kwok-Kun
Published: May 2024

By refining the volume estimate of Heintze and Karcher [11], we obtain a sharp pinching estimate for the genus of a surface in $$\mathbb S^{3}$$

S
3

, which involves an integral of the norm of its traceless second fundamental form. More specifically, we show that if g is the genus of a closed orientable surface $$\Sigma $$
Σ
in a 3-dimensional orientable Riemannian manifold M whose sectional curvature is bounded below by 1, then $$4 \pi ^{2} g(\Sigma ) \le 2\left( 2 \pi ^{2}-|M|\right) +\int _{\Sigma } f(|{\mathop {A}\limits ^{\circ }}|)$$

4

π
2

g

(
Σ
)

≤
2

2

π
2

-

|
M
|

+

∫
Σ

f
(
|

A
∘

|
)

, where $$ {\mathop {A}\limits ^{\circ }} $$

A
∘

is the traceless second fundamental form and f is an explicit function. As a result, the space of closed orientable embedded minimal surfaces $$\Sigma $$
Σ
with uniformly bounded $$\Vert A\Vert _{L^3(\Sigma )}$$

‖
A
‖

L
3

(
Σ
)

is compact in the $$C^k$$

C
k

topology for any $$k\ge 2$$

k
≥
2

.
Urbanization of a Subtropical Island (Okinawa, Japan) Alters Physicochemical Characteristics and Disrupts Microbial Community Dynamics in Nearshore Ecosystems
Authors: Mars Brisbin Margaret , Dudley Kenneth L. , Yonashiro Yoshitaka , Mitarai Satoshi , Ares Angela
Published: May 2024

Subtropical and tropical islands are undergoing rapid urbanization as the human population expands globally. Urbanization disrupts coastal ecosystems through several pathways—including the replacement of natural habitats with concrete structures that increase runoff pollution—but it remains difficult to isolate and characterize specific impacts of urbanization on marine ecosystems. The historical gradient in urbanization on the subtropical island of Okinawa, Japan, sets up a natural laboratory to study urbanization effects on nearshore ecosystems. Physicochemical parameters and bacterial community composition were assessed every 2 weeks for 1 year at two nearshore sites adjacent to watersheds with > 70% urban land use and two nearshore sites adjacent to watersheds with > 70% rural land use. Urbanization increased freshwater input and nutrient loading—indicated by decreased salinity and elevated nitrate + nitrite, ammonium, and phosphate at urban sites—despite the urban sites being more open to flushing due to land reclamation projects filling in the coral lagoon. Urbanization significantly altered microbial community composition by increasing diversity through the addition of fecal indicator and pathogenic bacteria—eight orders of bacteria were only detected in urban samples, whereas only Verrucomicrobiales was unique to rural samples. The change in microbial community composition at urban sites persisted throughout the seasonal cycle, suggesting a regime change or sustained disturbance. The altered physicochemical conditions and microbial communities at urban sites could degrade nearby coral reefs and their ecosystem services, highlighting the importance of coastal land management in marine conservation efforts.
Smart Data Driven Decision Trees Ensemble Methodology for Imbalanced Big Data
Authors: García-Gil Diego , García Salvador , Xiong Ning , Herrera Francisco
Published: May 2024

Differences in data size per class, also known as imbalanced data distribution, have become a common problem affecting data quality. Big Data scenarios pose a new challenge to traditional imbalanced classification algorithms, since they are not prepared to work with such amount of data. Split data strategies and lack of data in the minority class due to the use of MapReduce paradigm have posed new challenges for tackling the imbalance between classes in Big Data scenarios. Ensembles have been shown to be able to successfully address imbalanced data problems. Smart Data refers to data of enough quality to achieve high-performance models. The combination of ensembles and Smart Data, achieved through Big Data preprocessing, should be a great synergy. In this paper, we propose a novel Smart Data driven Decision Trees Ensemble methodology for addressing the imbalanced classification problem in Big Data domains, namely SD_DeTE methodology. This methodology is based on the learning of different decision trees using distributed quality data for the ensemble process. This quality data is achieved by fusing random discretization, principal components analysis, and clustering-based random oversampling for obtaining different Smart Data versions of the original data. Experiments carried out in 21 binary adapted datasets have shown that our methodology outperforms random forest.
Großschadensereignisse und Katastrophen
Authors: Treptow Rainer
Published: May 2024

Bei Großschadensereignissen und Katastrophen sind für Bevölkerungsschutz, Katastrophenhilfe und humanitäre Hilfe die Zuständigkeiten einigermaßen deutlich, doch wie sieht es für unterschiedliche Felder der Bildung und der Sozialen Arbeit aus? Spielen sie im Gefüge der „Sicherheitsarchitektur“ und der Steuerungslogiken von Innen- und Außenpolitik eine Rolle, und wenn ja, welche Erwartungen werden an sie gerichtet? Im Folgenden werden Einblicke in die bundesdeutsche und internationale Forschung gegeben, Fragen an erziehungswissenschaftliche und sozialpädagogische Diskurse zur Katastrophenpädagogik, schließlich an die Störanfälligkeit psychosozialer Dienste unter Extrembelastungen gestellt. Dabei bildet die jüngere Entwicklung von Vielfachkrisen aus Kriegen und sozialökologischen Gefährdungen den Hintergrund. Abschließend folgt eine Skizze zu räumlichen, zeitlichen und sozialen Dimensionen des Wissens- und Kompetenzbedarfs.
Gel-Based Triboelectric Nanogenerators for Flexible Sensing: Principles, Properties, and Applications
Authors: Lu Peng , Liao Xiaofang , Guo Xiaoyao , Cai Chenchen , Liu Yanhua , Chi Mingchao , Du Guoli , Wei Zhiting , Meng Xiangjiang , Nie Shuangxi
Published: May 2024

The rapid development of the Internet of Things and artificial intelligence technologies has increased the need for wearable, portable, and self-powered flexible sensing devices. Triboelectric nanogenerators (TENGs) based on gel materials (with excellent conductivity, mechanical tunability, environmental adaptability, and biocompatibility) are considered an advanced approach for developing a new generation of flexible sensors. This review comprehensively summarizes the recent advances in gel-based TENGs for flexible sensors, covering their principles, properties, and applications. Based on the development requirements for flexible sensors, the working mechanism of gel-based TENGs and the characteristic advantages of gels are introduced. Design strategies for the performance optimization of hydrogel-, organogel-, and aerogel-based TENGs are systematically summarized. In addition, the applications of gel-based TENGs in human motion sensing, tactile sensing, health monitoring, environmental monitoring, human–machine interaction, and other related fields are summarized. Finally, the challenges of gel-based TENGs for flexible sensing are discussed, and feasible strategies are proposed to guide future research.
[Birdsong]: Pedagogies of Attunement and Surrender with More-than-Human Teachers
Authors: Sidebottom Kay , Mycroft Lou
Published: May 2024

Our current ecological predicament requires a shift to a post-anthropocentric educational paradigm in which we educate for and about a world that is not “for us,” but comprised of a multitude of eco-systems of which we are simply a part. To facilitate this, education should be enacted differently; we need to experience learning not as furthering entrenched nature/culture binaries, but as “worlding” processes, whereby imaginary divides between individual and environment are troubled, as humans and the material world are revealed to be relational and entangled. Posthumanism offers an affective turn towards a social and ecological justice that accounts for such entanglements; enacted through necessary processes of de-familiarisation from the dominant vision of education. In this article we firstly explore the theoretical underpinnings of critical posthumanism to critique sustainability education-as-usual and propose new modes of teaching that lean into affective processes of noticing and surrender. We then discuss a research project in which participants came together to explore what happens when we cease to privilege humans as the ultimate instructors and holders of knowledge. In doing so we disrupt normative methodologies, drawing on affect, embodiment, relationality, transdisciplinarity and an ethics of care which extend learning to more-than-human kin.
Seeding and feeding milestones: the role of human milk microbes and oligosaccharides in the temporal development of infant gut microbiota
Authors: Endika Martha F. , Barnett David J. M. , Klostermann Cynthia E. , Kok Noortje , Schols Henk A. , Nauta Arjen , Arts Ilja C. W. , Penders John , Venema Koen , Smidt Hauke
Published: May 2024

Breastfeeding represents a strong selective factor for shaping the infant gut microbiota. Besides providing nutritional requirements for the infant, human milk is a key source of oligosaccharides, human milk oligosaccharides (HMOs), and diverse microbes in early life. This study aimed to evaluate the influence of human milk microbiota and oligosaccharides on the composition of infant faecal microbiota at one, three, and nine months postpartum. We profiled milk microbiota, HMOs, and infant faecal microbiota from 23 mother–infant pairs at these time points. The predominant genera in milk samples were Streptococcus, Staphylococcus, and an unclassified Enterobacteriaceae genus-level taxon (Enterobacteriaceae uncl.), whereas the infant faecal microbiota was predominated by Bifidobacterium, Bacteroides, and Enterobacteriaceae uncl. Mother–infant dyads frequently shared bacterial amplicon sequence variants (ASVs) belonging to the genera Bifidobacterium, Streptococcus, Enterobacteriaceae uncl., Veillonella, Bacteroides, and Haemophilus. The individual HMO concentrations in the milk showed either no change or decreased over the lactation period, except for 3-fucosyllactose (3-FL), which increased. Neither maternal secretor status nor HMO concentrations were significantly associated with microbiota composition at the different ages or the bacterial ASVs of maternal milk and infant faeces. This study suggests an age-dependent role of milk microbes in shaping the gut microbiota, while variations in HMO concentrations show limited influence.
One British Archive: Archives of Dissent: Complicating Anti-colonial Histories through the Watson Commission (Gold Coast/Ghana)
Authors: Hart Jennifer
Published: May 2024

This short article describes the content and impact of the files related to the Watson Commission, a commission of enquiry empowered by British colonial government officials to investigate the causes and consequences of the riots that rocked the city of Accra (Gold Coast Colony) in 1948. They comprise a collection of reports and testimonies from a wide range of people from across the social, economic, and political spectrum of the colonial Gold Coast. In a colonial archive that often privileges the voices of British government officials, technocrats, and African politicians, this collection of 32 files represents an unprecedented insight into the lived experience of a wide range of individuals and communities, and documents the processes that led to independence for the nation-state of Ghana.
Standing waves, localised near the shoreline of a water basin, and asymptotic quasimodes
Authors: Lyalinov Mikhail A.
Published: May 2024

In this work, formal asymptotic solutions of a problem for linear water waves in a bounded basin are constructed. The solutions have the form of asymptotic quasimodes and are used for the description of standing water waves localised near the shoreline. Such short-wavelength quasimodes exist only for a discrete set of frequencies, which are determined by means of a quantisation-type condition. Some numerical results are also addressed.
Influence of vibrational non-equilibrium on the dynamics of velocity gradients in compressible flows
Authors: Srivastava Shishir , Bhat Farooq Ahmad , Sinha Sawan S.
Published: May 2024

Analysing the dynamics of velocity gradients is useful for understanding various nonlinear turbulence processes. This work focuses on how the vibrational non-equilibrium of the constituent molecules in a gaseous medium affects the dynamics of the velocity gradient and the pressure Hessian tensors. We first derive the exact evolution equation of the pressure-Hessian tensor in the presence of the vibrational non-equilibrium process. Subsequently, we perform several direct numerical simulations of compressible isotropic turbulence, including the vibrational relaxation process therein. Using flow fields extracted from these simulations, we conduct several parametric studies over a range of the Damköhler number (ratio of the relevant fluid time scale to that of the mean vibrational relaxation process) and the initial ratio of the vibrational temperature to the mean local temperature. We find that a variation in the initial Damköhler number does influence the evolution of the pressure-Hessian and the velocity gradient tensors. As the vibrational relaxation process becomes more rapid (an increase in the value of the initial Damköhler number), it causes a decrease in the strength of the pressure-Hessian tensor and simultaneous suppression of dilatational fluctuations in the flow field. On the other hand, a variation in the initial value of the ratio of the vibrational temperature to the local temperature does not seem to affect the pressure-Hessian or the velocity gradient tensor. These findings are expected to aid in the development of closure models for the pressure-Hessian tensor in compressible flows under vibrational non-equilibrium conditions.
Enhancing transport barriers with swimming micro-organisms in chaotic flows
Authors: Ran Ranjiangshang , Arratia Paulo E.
Published: May 2024

We investigate the effects of bacterial activity on the mixing and transport properties of a passive scalar in time-periodic flows in experiments and in a simple model. We focus on the interactions between swimming Escherichia coli and the Lagrangian coherent structures (LCSs) of the flow, which are computed from experimentally measured velocity fields. Experiments show that such interactions are non-trivial and can lead to transport barriers through which the scalar flux is significantly reduced. Using the Poincaré map, we show that these transport barriers coincide with the outermost members of elliptic LCSs known as Lagrangian vortex boundaries. Numerical simulations further show that elliptic LCSs can repel elongated swimmers and lead to swimmer depletion within Lagrangian coherent vortices. A simple mechanism shows that such depletion is due to the preferential alignment of elongated swimmers with the tangents of elliptic LCSs. Our results provide insights into understanding the transport of micro-organisms in complex flows with dynamical topological features from a Lagrangian viewpoint.
Medicare Should Cover Weight Loss Drugs as Long as the Prices are Affordable
Authors: Hwang Catherine S. , Kesselheim Aaron S. , Rome Benjamin N.
Published: May 2024

Glucagon-like peptide-1 receptor agonists are effective for treating obesity, but the high cost of these medications endangers the financial viability of our health care system. To ensure that these drugs are available to Medicare beneficiaries, pharmaceutical manufacturers must lower their prices.
Addressing Unmet Social Needs and Social Risks — A Qualitative Interview-Based Assessment of Parent Reported Outcomes and Impact from a Medical Legal Partnership
Authors: Paquette Erin Talati , Saper Jennifer Kusma , Khan Hassan , Becker Sasha , Guzman Zecilly , Renteria Valerie Alvarez , Hess Sarah , Sheehan Karen
Published: May 2024

Medical legal partnerships address individual legal needs that can create impediments to health. Little is known about outcomes from medical legal partnerships and their relationship to access to justice. This paper reports outcomes from one medical legal partnership from the perspective of the client, with specific emphasis on impact on health and concepts related to access to justice. We suggest a conceptual model for incorporating medical legal partnerships into a broader framework about access to justice.
Development and validity of the ‘Modified Mediterranean Prime Screen’ to assess dietary intake among women of reproductive age in Lebanon
Authors: Assaad Mariam , Ajjour Sara , Rahme Maya , Al-Shaar Laila , Sakr May , Ghattas Hala , El-Hajj Fuleihan Ghada , Jabbour Jana
Published: May 2024

The Mediterranean Region registers an increasing prevalence of obesity. The region lacks a diet screener to assess obesogenic nutrients. This study aimed to evaluate the reproducibility and validity of the Modified Mediterranean Prime Screen (MMPS) in estimating obesogenic nutrients’ intake among women of reproductive age, as compared with a culturally validated Food Frequency Questionnaire (FFQ), in Lebanon. We developed the MMPS consisting of thirty-two food/beverage items specific to the Lebanese Mediterranean culture. The MMPS and FFQ were administered in two visits (2 weeks–6 months apart), face to face and via telephone during the coronavirus disease 2019 pandemic. The reproducibility and validity of the MMPS were assessed using intraclass correlation coefficients (ICC) and Pearson’s correlations, respectively. The study included 143 women, aged 31·5 (sd 4·6) years, BMI 24·2 (sd 4·0) kg/m2, 87 % with university education and 91 % food secure. The reproducibility of the MMPS was moderate for energy and all assessed nutrients except for SFA (ICC = 0·428). The agreement of the MMPS with the reference FFQ was adequate for energy and obesogenic nutrients. Yet, the Pearson correlations for energy-adjusted nutrient intake were low for trans-fatty acids (0·294) and PUFA (0·377). The MMPS can be a time-efficient tool for dietary assessment of energy and many obesogenic nutrients. Future studies should validate the MMPS across the lifespan and re-evaluate it after updating the fatty acid profiles in the culturally specific food composition tables.
Responses of the temperate calcareous sponge Grantia sp. to ocean acidification
Authors: McCullough Alice , Strano Francesca , Micaroni Valerio , Woods Lisa , Bell James J.
Published: May 2024

Sponges are important components of marine systems globally, and while sponges have generally been shown to tolerate ocean acidification (OA), most earlier studies have focused on demosponges with siliceous skeletons. In contrast, little is known of how calcareous sponges, with calcite or aragonite skeletons, may react to OA conditions. Here we measured tissue necrosis and respiration rate of the temperate New Zealand calcareous sponge Grantia sp. to simulated OA. Our treatment conditions were based on the IPCC RCP8.5 (pCO2 1131.9 ± 113 μatm) scenario over a 28 day experiment, and responses were compared to current day control conditions (pCO2 512.59 ± 23 μatm). Sponge respiration rate was not significantly different between the control and treatment sponges and there was no evidence of tissue necrosis over the course of the experiment. Overall, our study is consistent with earlier studies on demosponges, showing calcareous sponges to be resilient to OA.
Labour market exit routes in high- and low-educated older workers before and after social insurance and retirement policy reforms in Sweden
Authors: Almroth Melody , Falkstedt Daniel , Hemmingsson Tomas , Albin Maria , Badarin Kathryn , Selander Jenny , Gustavsson Per , Bodin Theo , Thern Emelie , Pan Kuan-Yu , Kjellberg Katarina
Published: May 2024

Few previous studies have investigated how socioeconomic differences in labour market exit have changed after restrictions in social insurance policies. The aim of this register-based study is to investigate how early labour market exit pathways among older men and women with different levels of education changed after major restrictive social insurance and retirement policy reforms in Sweden. Cohort 1 (pre-reform) consisted of individuals who were 60 or 61 years old in 2005 (N = 186,145) and Cohort 2 (post-reform) consisted of individuals who were 60 or 61 years old in 2012 (N = 176,216). Educational differences in four labour market exit pathways were investigated using Cox proportional hazards regression; the exit pathways were disability pension, early old-age pension with and without income respectively, and no income for two consecutive years. As expected, exits through disability pension were rarer in Cohort 2. Lower education was also more strongly associated with disability pension in Cohort 2. Parallel to this, lower education showed a stronger association with both early old-age pension types in Cohort 2. Additionally, a tendency towards a relatively higher likelihood of earning no income was seen among the less educated. Increases in inequalities tended to be greater for women. Our results indicate that educational inequalities in labour market exit have grown significantly after restrictions in social insurance and changes in retirement policies, which can have negative financial repercussions for those already in a vulnerable position. These results indicate that careful analyses of effects on disparities are needed before making major changes in welfare systems.
IDENTIFICATION AND STATISTICAL DECISION THEORY
Authors: Manski Charles F.
Published: May 2024

Econometricians have usefully separated study of estimation into identification and statistical components. Identification analysis, which assumes knowledge of the probability distribution generating observable data, places an upper bound on what may be learned about population parameters of interest with finite-sample data. Yet Wald’s statistical decision theory studies decision-making with sample data without reference to identification, indeed without reference to estimation. This paper asks if identification analysis is useful to statistical decision theory. The answer is positive, as it can yield an informative and tractable upper bound on the achievable finite-sample performance of decision criteria. The reasoning is simple when the decision-relevant parameter (true state of nature) is point-identified. It is more delicate when the true state is partially identified and a decision must be made under ambiguity. Then the performance of some criteria, such as minimax regret, is enhanced by randomizing choice of an action in a controlled manner. I find it useful to recast choice of a statistical decision function as selection of choice probabilities for the elements of the choice set.
« Faut pas faire ça meuf ! » – La (non-)réalisation du ne de négation et du il impersonnel dans les bandes dessinées de Riad Sattouf
Authors: Leis Sabine
Published: May 2024

Dans le présent article, nous proposons une analyse de la mise en scènes de la (non-)réalisation du ne de négation et du il impersonnel dans un corpus de onze bandes dessinées de l’auteur franco-syrien Riad Sattouf. Notre objectif est double: d’une part, il s’agit de confronter cette mise en scène aux résultats des études de corpus oraux et, d’autre part, nous voulons la situer par rapport aux résultats d’autres études sur la mise en scène de l’oralité dans la bande dessinée. Pour ce faire, nous examinons des variables internes (p. ex. le type du forclusif ou les verbes impersonnels) et externes (p. ex. l’âge du personnage) et catégorisons nos résultats selon le modèle de proximité et de distance communicatives de Koch/Oesterreicher (22011). Le corpus utilisé se compose de toutes les bandes dessinées hors-série et d’une bande dessinée par série de Sattouf publiées entre 2003 et 2021. Notre article montre qu’il existe des similitudes entre la mise en scène sattoufienne et les pratiques orales au niveau des variables internes. Nous constatons cependant de grandes différences en ce qui concerne la variation de la (non-)réalisation du ne et du il en fonction des variables externes.
Estuarine Adjustment: Dependence of Salinity Delay on the Forcing Timescale and Magnitude
Authors: Dijkstra Yoeri M.
Published: May 2024

The salinity in estuaries continuously adapts to varying forcing for example, by discharge and tidal conditions. The changes in salinity lag behind the changes in forcing. Previous work has mostly related this delay to the adjustment time, which depends on an average background state of the estuary. Payo‐Payo et al. (2022), https://doi.org/10.1029/2021jc017523 showed that adjustment time however cannot explain the actually observed delays for a realistic salinity and forcing signal. Inspired by this, this study aims to develop relations between delay time and forcing variations and background state of the estuary. To this end, I first propose a definition of the actual delay of salinity based on wavelet analysis, applicable to observed or modeled salinity signals. To compare delay to estuarine parameters, I use a linear 1D model, but qualitative results carry over to the general case. Using model experiments with harmonic and peaked variations in the forcing, the delay time depends not only on the adjustment time, but also on the timescale of the forcing variation. Even for forcing timescales that are up to a factor 100 longer than the adjustment time, both forcing timescale and adjustment time are important for the delay. A second novel finding is that the delay depends strongly on the position along the estuary where the delay is observed. As verification, model experiments with realistically varying forcing were done, roughly inspired by the Modaomen Estuary (China). Although delay times showed a complicated and scattered dependency on model variables in this case, the above qualitative conclusions were confirmed.
Observations of Barrier Layer Seasonal Variation in the Banda Sea
Authors: Ismail M. F. A. , Karstensen J. , Sulaiman A. , Priyono B. , Budiman A. , Basit A. , Purwandana A. , Arifin T.
Published: May 2024

The Banda Sea is of crucial importance for the circulation of the world's oceans, as it is part of the connection between the Pacific to the Indian Ocean. One peculiarity of the upper ocean hydrography in the Banda Sea is the occurrence of barrier layers. The regionality and temporal variability of barrier layer thickness (BLT) in the Banda Sea are examined in this study utilizing in‐situ observations and ocean reanalysis output. It is found that a barrier layer occurs in over 90 % of the observational data profiles, and in over 72 % of those profiles, the BLT is shallower than 10 m. Furthermore, we find a seasonal cycle in BLT with a maximum thickness of about 60 m occurring during austral autumn and winter and coinciding with the presence of low saline waters fed by the regional river discharge and rainfall from the Java Sea and Makassar Strait. In addition, we identify the existence of a quasi‐permanent anticyclonic circulation cell in the Banda Sea that may support the trapping of surface freshwater by retention. The anticyclonic circulation is most likely wind‐driven because it coincides with the regional Ekman pumping pattern. Modulation of the anticyclone is via seasonal variability in the wind stress curl which in turn may explain the efficiency of freshwater retention and thus the BLT. The annual mean BLT distribution in the Banda Sea shows a preferential region of thickened barrier layers around 6o‐8oS and 124o‐126oE and resampling the pattern of the monthly mean climatology.
The real-time infection hospitalisation and fatality risk across the COVID-19 pandemic in England
Authors: Ward Thomas , Fyles Martyn , Glaser Alex , Paton Robert S. , Ferguson William , Overton Christopher E.
Published: May 2024

The COVID-19 pandemic led to 231,841 deaths and 940,243 hospitalisations in England, by the end of March 2023. This paper calculates the real-time infection hospitalisation risk (IHR) and infection fatality risk (IFR) using the Office for National Statistics Coronavirus Infection Survey (ONS CIS) and the Real-time Assessment of Community Transmission Survey between November 2020 to March 2023. The IHR and the IFR in England peaked in January 2021 at 3.39% (95% Credible Intervals (CrI): 2.79, 3.97) and 0.97% (95% CrI: 0.62, 1.36), respectively. After this time, there was a rapid decline in the severity from infection, with the lowest estimated IHR of 0.32% (95% CrI: 0.27, 0.39) in December 2022 and IFR of 0.06% (95% CrI: 0.04, 0.08) in April 2022. We found infection severity to vary more markedly between regions early in the pandemic however, the absolute heterogeneity has since reduced. The risk from infection of SARS-CoV-2 has changed substantially throughout the COVID-19 pandemic with a decline of 86.03% (80.86, 89.35) and 89.67% (80.18, 93.93) in the IHR and IFR, respectively, since early 2021. From April 2022 until March 2023, the end of the ONS CIS study, we found fluctuating patterns in the severity of infection with the resumption of more normative mixing, resurgent epidemic waves, patterns of waning immunity, and emerging variants that have shown signs of convergent evolution.
The peptidase DA1 cleaves and destabilizes WUSCHEL to control shoot apical meristem size
Authors: Cui Guicai , Li Yu , Zheng Leiying , Smith Caroline , Bevan Michael W. , Li Yunhai
Published: May 2024

Stem cells in plants and animals are the source of new tissues and organs. In plants, stem cells are maintained in the central zone (CZ) of multicellular meristems, and large shoot meristems with an increased stem cell population hold promise for enhancing yield. The mobile homeodomain transcription factor WUSCHEL (WUS) is a central regulator of stem cell function in plant shoot meristems. Despite its central importance, the factors that directly modulate WUS protein stability have been a long-standing question. Here, we show that the peptidase DA1 physically interacts with and cleaves the WUS protein, leading to its destabilization. Furthermore, our results reveal that cytokinin signaling represses the level of DA1 protein in the shoot apical meristem, thereby increasing the accumulation of WUS protein. Consistent with these observations, loss of DA1 function results in larger shoot apical meristems with an increased stem cell population and also influences cytokinin-induced enlargement of shoot apical meristem. Collectively, our findings uncover a previously unrecognized mechanism by which the repression of DA1 by cytokinin signaling stabilizes WUS, resulting in the enlarged shoot apical meristems with the increased stem cell number during plant growth and development.
Intrinsic and synaptic determinants of receptive field plasticity in Purkinje cells of the mouse cerebellum
Authors: Lin Ting-Feng , Busch Silas E. , Hansel Christian
Published: May 2024

Non-synaptic (intrinsic) plasticity of membrane excitability contributes to aspects of memory formation, but it remains unclear whether it merely facilitates synaptic long-term potentiation or plays a permissive role in determining the impact of synaptic weight increase. We use tactile stimulation and electrical activation of parallel fibers to probe intrinsic and synaptic contributions to receptive field plasticity in awake mice during two-photon calcium imaging of cerebellar Purkinje cells. Repetitive activation of both stimuli induced response potentiation that is impaired in mice with selective deficits in either synaptic or intrinsic plasticity. Spatial analysis of calcium signals demonstrated that intrinsic, but not synaptic plasticity, enhances the spread of dendritic parallel fiber response potentiation. Simultaneous dendrite and axon initial segment recordings confirm these dendritic events affect axonal output. Our findings support the hypothesis that intrinsic plasticity provides an amplification mechanism that exerts a permissive control over the impact of long-term potentiation on neuronal responsiveness.
Atomistic mechanism of coupling between cytosolic sensor domain and selectivity filter in TREK K2P channels
Authors: Türkaydin Berke , Schewe Marcus , Riel Elena Barbara , Schulz Friederike , Biedermann Johann , Baukrowitz Thomas , Sun Han
Published: May 2024

The two-pore domain potassium (K2P) channels TREK-1 and TREK-2 link neuronal excitability to a variety of stimuli including mechanical force, lipids, temperature and phosphorylation. This regulation involves the C-terminus as a polymodal stimulus sensor and the selectivity filter (SF) as channel gate. Using crystallographic up- and down-state structures of TREK-2 as a template for full atomistic molecular dynamics (MD) simulations, we reveal that the SF in down-state undergoes inactivation via conformational changes, while the up-state structure maintains a stable and conductive SF. This suggests an atomistic mechanism for the low channel activity previously assigned to the down state, but not evident from the crystal structure. Furthermore, experimentally by using (de-)phosphorylation mimics and chemically attaching lipid tethers to the proximal C-terminus (pCt), we confirm the hypothesis that moving the pCt towards the membrane induces the up-state. Based on MD simulations, we propose two gating pathways by which movement of the pCt controls the stability (i.e., conductivity) of the filter gate. Together, these findings provide atomistic insights into the SF gating mechanism and the physiological regulation of TREK channels by phosphorylation.
Evolved histone tail regulates 53BP1 recruitment at damaged chromatin
Authors: Kelliher Jessica L. , Folkerts Melissa L. , Shen Kaiyuan V. , Song Wan , Tengler Kyle , Stiefel Clara M. , Lee Seong-Ok , Dray Eloise , Zhao Weixing , Koss Brian , Pannunzio Nicholas R. , Leung Justin W.
Published: May 2024

The master DNA damage repair histone protein, H2AX, is essential for orchestrating the recruitment of downstream mediator and effector proteins at damaged chromatin. The phosphorylation of H2AX at S139, γH2AX, is well-studied for its DNA repair function. However, the extended C-terminal tail is not characterized. Here, we define the minimal motif on H2AX for the canonical function in activating the MDC1-RNF8-RNF168 phosphorylation-ubiquitination pathway that is important for recruiting repair proteins, such as 53BP1 and BRCA1. Interestingly, H2AX recruits 53BP1 independently from the MDC1-RNF8-RNF168 pathway through its evolved C-terminal linker region with S139 phosphorylation. Mechanistically, 53BP1 recruitment to damaged chromatin is mediated by the interaction between the H2AX C-terminal tail and the 53BP1 Oligomerization-Tudor domains. Moreover, γH2AX-linker mediated 53BP1 recruitment leads to camptothecin resistance in H2AX knockout cells. Overall, our study uncovers an evolved mechanism within the H2AX C-terminal tail for regulating DNA repair proteins at damaged chromatin.
Determinants of incomplete penta vaccination among children aged 12 to 23 months in South-West Ethiopia
Authors: Kefeni Bilisumamulifna Tefera , Chibsa Samuel Ejeta , Roba Debele Gebiso
Published: May 2024

Globally dropout rate for the three dose of penta (DPT) vaccine was highest in the African region. This mainly occurred in the African Region including Ethiopia. Despite high national incomplete vaccination status, there is lack of study on the determinants of incomplete vaccination in south west region, Ethiopia. Therefore, this study was conducted to identify determinants of incomplete Penta vaccination among children aged 12 to 23 months in Mettu district South-West Ethiopia. A Community based case–control study was conducted from April 24, May 23, 2022 in South-west Ethiopia. Data was collected from 297 participants (99 cases and 198controls) by using simple random sampling techniques. Cases were children age from 9 to 23 months who missed at least one dose from the routine vaccine and controls were completed the entire routine vaccine schedule. Data was entered to Epi-data version 3.1 and exported to SPSS version 23 for statistical analyses. Binary and multivariable logistic regression with a 95% CI and a p-value of < 0.05 was done to declare statistical significance. A total of 95 cases and 197 controls participated in the study. Rural residence [AOR: 3.9; 95% CI; (1.6, 9.4)], wealth indexes [AOR: 3.6; 95% CI; (1.8,7.0)], mothers unimmunized tetanus toxoid [AOR: 4.3; 95% CI; (2.1, 8.6)], postponed schedule [AOR: 4.6; 95% CI; (2.4, 8.8)], un satisfied to service [AOR: 3.7; 95% CI; (1.7,7.6)] and poor perception on benefit of vaccine [AOR:2.7; 95% CI; (1.2, 6.1)] were determinants of incomplete vaccination. Rural Residence, Family wealth index of poor; Mother not received tetanus vaccination; postponed vaccination schedule client satisfaction and caretaker perception on benefit of vaccination were identified determinants of incomplete vaccination.

Health information should be given for the community and child caretaker on the benefit of complete vaccination. Community should be encouraged to not post pond vaccine schedule. Pregnant women should be strengthening to receive tetanus toxoid vaccine during pregnancy.
Establishment of a risk prediction model for olfactory disorders in patients with transnasal pituitary tumors by machine learning
Authors: Chen Min , Li Yuxin , Zhou Sumei , Zou Linbo , Yu Lei , Deng Tianfang , Rong Xian , Shao Shirong , Wu Jijun
Published: May 2024

To construct a prediction model of olfactory dysfunction after transnasal sellar pituitary tumor resection based on machine learning algorithms. A cross-sectional study was conducted. From January to December 2022, 158 patients underwent transnasal sellar pituitary tumor resection in three tertiary hospitals in Sichuan Province were selected as the research objects. The olfactory status was evaluated one week after surgery. They were randomly divided into a training set and a test set according to the ratio of 8:2. The training set was used to construct the prediction model, and the test set was used to evaluate the effect of the model. Based on different machine learning algorithms, BP neural network, logistic regression, decision tree, support vector machine, random forest, LightGBM, XGBoost, and AdaBoost were established to construct olfactory dysfunction risk prediction models. The accuracy, precision, recall, F1 score, and area under the ROC curve (AUC) were used to evaluate the model's prediction performance, the optimal prediction model algorithm was selected, and the model was verified in the test set of patients. Of the 158 patients, 116 (73.42%) had postoperative olfactory dysfunction. After missing value processing and feature screening, an essential order of influencing factors of olfactory dysfunction was obtained. Among them, the duration of operation, gender, type of pituitary tumor, pituitary tumor apoplexy, nasal adhesion, age, cerebrospinal fluid leakage, blood scar formation, and smoking history became the risk factors of olfactory dysfunction, which were the key indicators of the construction of the model. Among them, the random forest model had the highest AUC of 0.846, and the accuracy, precision, recall, and F1 score were 0.750, 0.870, 0.947, and 0.833, respectively. Compared with the BP neural network, logistic regression, decision tree, support vector machine, LightGBM, XGBoost, and AdaBoost, the random forest model has more advantages in predicting olfactory dysfunction in patients after transnasal sellar pituitary tumor resection, which is helpful for early identification and intervention of high-risk clinical population, and has good clinical application prospects.
A comprehensive performance analysis of advanced hybrid MPPT controllers for fuel cell systems
Authors: Touti Ezzeddine , Rafikiran Shaik , Graba Besma Bechir , Aoudia Mouloud , Senthilkumar S.
Published: May 2024

The present power generation corporations are working on Renewable Power Systems (RPS) for supplying electrical power to the automotive power industries. There are several categories of RPSs available in the atmosphere. Among all of the RPSs, the most general power network used for Electric Vehicles (EVs) is hydrogen fuel which is available in nature. The H2 fuel is fed to the Proton Exchange Membrane Fuel Stack (PEMFS) for producing electricity for the EV stations. The advantages of this selected fuel system are more power conversion efficiency, environmentally friendly, low carbon emissions, more power density, less starting time, plus able to work at very low-temperature values. However, this fuel stack faces the issue of a nonlinear power density curve. Due to this nonlinear power supply from the fuel stack, the functioning point of the overall network changes from one position of the I–V curve to another position. So, the peak voltage extraction from the fuel stack is not possible. In this article, there are various metaheuristic optimization-based Maximum Power Point Tracking (MPPT) methodologies are studied along with the conventional methods for obtaining the Maximum Power Point (MPP) position of the PEMFS. From the simulative investigation, the Continuous Different Slope Value-based Cuckoo Search Method (CDSV with CSM) provides better efficiency with more output power. Also, for all the MPPT methods comprehensive analysis has been made by utilizing the simulation results.
Objectivity interrogation of racial scholarship in psychology and management
Authors: Torrez Brittany , Dupree Cydney H. , Kraus Michael W.
Published: May 2024

Scholars of color remain underrepresented in US institutions in academia. In this paper, we will examine one factor that contributes to their continued marginalization in psychology and management: the scientific method’s commitment to traditional notions of objectivity. We argue that objectivity—defined as practices and policies rooted in the heightened value placed on a research process that is ostensibly free from bias—is central to the prominence of primarily White scholarship in psychology and management research and remains central to knowledge production. To investigate this, we employ a mixed-methods approach, integrating qualitative and quantitative data to codify how scholars of color experience objectivity interrogations, or written and verbal questioning in academic contexts that implicates their scientific rigor. We also identify how scholars of color engage in objectivity armoring, or self-presentational strategies (toning down and stepping up) to contend with these interrogations. Finally, we reveal these toning down processes in language use within publications on racial scholarship. Overall, these studies reveal the unique challenges scholars of color face to legitimize and validate their work on race and racism within predominantly White institutions and disciplines.