bluuebunny/crossref_metadata_2025 huggingface dataset:
An integrated analysis of whole transcriptome and epigenome data reveals ENSR00000272060, an enhancer RNA, as a potential diagnostic biomarker in gastric cancer
Authors: Bahrami Basireh , Wolfien Markus , Nikpour Parvaneh
Published: July 2022

Enhancer RNAs (eRNAs) are a type of non-coding RNAs that are involved in gene expression regulation. Although altered expression and functional roles of eRNAs in the pathophysiology of neoplasms have been reported, their role in gastric cancer (GC), one of the most common and lethal cancers, is less known. In this work, we utilized a network-based approach for analyzing transcriptome and epigenome alteration in GC using The Cancer Genome Atlas (TCGA) data portal. A hub eRNA from the network: ENSR00000272060, showed a significantly increased expression in GC tumoral compared to the non-tumoral tissues, as well as an association with prognosis-related clinicopathological features. The constructed regulatory network of eRNAs and target genes in GC presents a comprehensive understanding of the underlying processes involved in tumor development, as well as a potential start to derive diagnostic or prognostic biomarkers.
Efficacy of subthreshold trabeculoplasty with micropulse laser in the treatment of primary open angle glaucoma
Authors: Parolini Barbara , Sahyoun Jean-Yves , Carbognin Sara , Tozzi Luigi , Gius irene , Greggio Angelo , Frisina Rino
Published: July 2022

Purpose
To report the results of subthreshold micropulse laser trabeculoplasty (MLT) in a consecutive series of patients, affected by primary open angle glaucoma (POAG).
Methods
In this single-center, one-arm, prospective study conducted on sixty-eight patients (112 eyes) affected by POAG, who underwent 360° 577-nm MLT. Follow-up consultations were scheduled at 1, 6, 12, 18 and 24 months. At baseline and at each consultation after MLT, data were collected on IOP, best corrected visual acuity, local and systemic side effects, number of eye-drops in use.
Results
One-hundred and twelve eyes of 68 patients were enrolled. Mean age was 57.68 ± 8.0 years, mean baseline IOP was 18.4 ± 5.2 mmHg with 1.43 ± 0.85 glaucoma medications. Treatment with MLT resulted in significantly lower IOP at both 1 month (18.4 ± 5.2mmHg, p = 0.045) and 24 months (18.4 ± 5.2 mmHg; p = 0.046) compared to baseline. No statistically significant difference was found between IOP at 1 month and at 12 months and between IOP at 1 month and at 24 months after treatment (p > 0.05). A low rate of retreatments was observed, mostly performed after 18 months from baseline. Most of the eyes were free of additional medical therapy at 12 months (88.9%) and 24 months (94.3%). No local or systemic side effects during or after MLT were reported.
Conclusion
This is the first prospective study to report long-term outcomes of MLT in POAG. MLT is safe and effective with an efficacy achieved within the first month and maintained after 2 years of treatment.
The Use of Intercultural Interpreter Services at a Pediatric Emergency Department in Switzerland
Authors: Buser Sina , Gessler Noemi , Gmuender Myriam , Feuz Ursula , Jachmann Anne , Fayyaz Jabeen , Keitel Kristina , Brandenberger Julia
Published: July 2022

The aim of our study was to analyze the use of interpreter services and improve communication during health encounters with families with limited language proficiency (LLP) at the pediatric emergency department (ED) of the University Hospital of Bern. This study is a pre- and post-intervention study analyzing the use of interpreter services for LLP families. All families originating from a country with a native language other than German, English or French presenting to the ED were eligible to participate in the study. If they agreed to participate, the language proficiency of the caregiver present during the health encounter was systematically assessed during a phone interview within a few days after the consultation, using a standardized screening tool. If screened positive (relevant LLP), a second phone interview with an interpreter was conducted. Further variables were extracted including nationality, age, gender and date of visit using administrative health records. To increase the use of interpreter services, a package of interventions was implemented at the department during 3 months. It consisted of: i) in person and online transcultural teaching ii) awareness raising through the regular information channels and iii) the introduction of a pathway to systematically identify and manage LLP families. The proportion of LLP families who received an interpreter was 11.0% (14/127) in the pre-intervention period compared to 14.8% (20/135) in the post-intervention period. The interpreter use was therefore increased by 3.8% (95% CI -0.43 to 0.21; p = 0.36). The assessed level of language proficiency of caregivers differed from the self-reported level of language proficiency. Of the study participants in the interview whose language proficiency was screened as limited, 77.1% estimated their language proficiency level as intermediate. More than half of the LLP families who did not receive an interpreter and participated in the interview reported, that they would have liked an interpreter during the consultation. Conclusions: Interpreter services are largely underused during health encounters with LLP families. Relying on caregivers´ self-assessed language proficiency and their active request for an interpreter is not sufficient to ensure safe communication during health encounters. Systematic screening of language proficiency and standardized management of LLP families is feasible and needed at health care facilities to ensure equitable care. Further studies are needed to analyze personal and institutional barriers to interpreter use and find interventions to sustainably increase the use of interpreter services for LLP families.
Lignocellulose conversion via catalytic transformations yields biobased polyester from sawdust
Authors: Pedersen Simon , Batista Gabriel , Henriksen Martin , Hammershøj Hans Christian , Hopmann Kathrin , Skrydstrup Troels
Published: July 2022

Polyethylene terephthalate polyester represents the most common class of thermoplastic polymers widely used in the textile, bottling and packaging industries. Terephthalic acid and ethylene glycol, both of petrochemical origin, are polymerised to yield the polyester. However, an earlier report suggests replacement with 2-methoxyterephthalic acid provides a methoxy-polyester with equal properties. Currently, there are no established biobased synthetic routes towards methoxy-polyethylene terephthalate. Here we show a viable route to the polyester variant from various tree species involving three catalytic steps. We demonstrate that sawdust can be converted to valuable aryl nitrile intermediates through an efficient fluorosulfation-catalytic cyanation sequence (>90%), and then converted to methoxy-terephthalic acid by hydrolysis and oxidation. Our polymerisation results reveal similar decomposition and glass transition temperatures of methoxy-polyester in comparison with conventional polyester. This synthetic route towards a biobased methoxy-polyester is aligned with the general goal of polyester producing companies to replace this oil-based plastic with biobased alternatives.
Auditory and visual mating cues input, Interaction among the central biological clock and reproductive neuron in hypothalamic-pituitary- gonadal axis of Rhesus monkey: A potential cause of precocious puberty
Authors: Aslam Muhammad
Published: July 2022

Hypothalamic pituitary gonadal axis (HPG) operates and gated by multiple neurocircuits one of which is circadian system. Circadian system is necessary for reproduction. The impact of day, night length, electromagnetic radiation, hormone and food on circadian cycle and onset of puberty was well established but influence of two crucial visual and auditory mating cues was not yet determined. Biological clock suprachiasmatic nucleus (SCN) is connected to other reproduction regulating areas such as preoptic area (POA) anteroventral periventricular nucleus (AVPV) arcuate nucleus (ARC)and dorsomedial hypothalamus (DMH). Our finding has proved exposure of Visual and auditory mating cues significantly increased circadian clock regulatory protein expression GnRH neuropeptide and neurohormone that impart confounding impact on reproductive organ growth and early onset of puberty in prepubertal monkey (Macaca mulatto). The auditory and visual mating cues are thought to stimulate the SCN and gonadotropin releasing hormone (GnRH) neuron in POA with subsequent released FSH, LH and gonadal steroids.
Exploration of metabolites from gut microbiota against nonalcoholic fatty liver disease: A network pharmacology-based study
Authors: Oh Ki-Kwang , Gupta Haripriya , Min Byeong Hyun , Ganesan Raja , Sharma Satya Priya , Won Sung Min , Jeong Jin Ju , Lee Su Been , Cha Min Gi , Kwon Goo Hyun , Jeong Min Kyo , Hyun Ji Ye , Eom Jung A , Park Hee Jin , Yoon Sang Jun , Choi Mi Ran , Kim Dong Joon , Suk Ki Tae
Published: July 2022

Background: The metabolites of gut microbiota show favorable therapeutic effects on nonalcoholic fatty liver disease (NAFLD), but the active metabolites and mechanisms against NAFLD have not been documented. The aim of the study was to investigate the active metabolites and mechanisms of gut microbiota against NAFLD by network pharmacology. Results: We obtained a total of 208 metabolites from the gutMgene database and retrieved 1,256 targets from similarity ensemble approach (SEA) and 947 targets from the SwissTargetPrediction (STP) database. In the SEA and STP databases, we identified 668 overlapping targets and obtained 237 targets for NAFLD. Thirty-eight targets were identified out of those 237 and 223 targets retrieved from the gutMgene database, and were considered the final NAFLD targets of metabolites from the microbiome. The results of molecular docking tests suggest that, of the 38 targets, mitogen-activated protein kinase 8-compound K and glycogen synthase kinase-3 beta-myricetin complexes might inhibit the Wnt signaling pathway. The microbiota-signaling pathways-targets-metabolites network analysis reveals that Firmicutes, Fusobacteria, the Toll-like receptor signaling pathway, mitogen-activated protein kinase 1, and phenylacetylglutamine are notable components of NAFLD.Conclusion: The key components and potential mechanisms of metabolites from gut microbiota against NAFLD were explored utilizing network pharmacology analyses. This study provides scientific evidence to support the therapeutic efficacy of metabolites for NAFLD and suggests holistic insights for further research.
Jingfang Granule Protects Against Concanavalin-A-Induced Immune Hepatitis in Mice Through Regulating Tricarboxylic Acid Cycle
Authors: Zhang Yongkang , Liu Mingfei , Zhang Xiao , Cheng Guoliang , Lv Shimeng , Yang Tianye , Li Shirong , Wang Xishuang , Pan Lihong , Feng Qun , Sun Chenghong , Yao Jingchun , Zhang Guimin
Published: July 2022

Background
Autoimmune hepatitis (AIH) is an autoimmune mediated inflammatory disease that causes serious economic burden to mankind. Previous studies reported that Jingfang Granules (JFG) had an anti-inflammatory effect. However, there are few studies of JFG on AIH. The aim of the study was to investigate the therapeutic effect of JFG on AIH and its mechanisms of action.
Methods
The animal model of AIH was constructed by intravenous injection of Concanavalin A (Con A). JFG treatment was given by intragastric gavage (ig) after an hour later of injected Con A. Serum and liver tissues were collected after 24 h treatment. Mortality, histology, levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) in serum were to evaluate therapeutic effect of JFG. The apoptosis of hepatocyte was detected by terminal deoxynucleotidyl transferase mediated dUTP biotin nick end labeling assay (TUNEL). The expression of B-cell lymphoma-2 (Bcl-2), Bcl-2 Associated X (Bax), Cleaved-Caspase 3, Toll-like receptor 4 (TLR4)/nuclear factor kappa B p65 (NF-κB), Mitogen activated protein kinase (MAPK) pathways associated proteins, CS, IDH1, ACLY, SUCLG1, and SUCLA2 were measured by western blot. The inflammatory cytokines interleukin-1β (IL-1β), interleukin-4 (IL-4), interleukin-6 (IL-6), tumor necrosis factor (TNF)-α, interferon (IFN)-γ and anti-inflammatory cytokine interleukin-10 (IL-10) were checked by ELISA. The possible target mechanism of JFG in the treatment of AIH was explored by proteomics and metabolomics.
Results
The results showed that JFG substantially alleviated Con A-mediated hepatitis in mice, which was shown by increased survival rates, decreased of liver injury, aminotransferase, hepatocyte necrosis, and apoptosis. JFG could also regulate the production of inflammatory factors (IL-1β, IL-4, IL-6, TNF-α, IFN-γ and IL-10) by reduced the activation of TLR4/NF-κB and MAPK pathways. In addition, it was found that JFG could inhibit the inflammatory pathway by regulating tricarboxylic acid (TCA) cycle activity.
Conclusions
These results suggested that JFG played a therapeutic role in Con A-induced AIH by inhibiting liver injury, apoptosis, and inhibiting inflammatory pathway by regulating TCA cycle.
Biodegradation of pretreated chicken feather with keratinolytic bacteria Glutamicibacter arilaitensis
Authors: Chellapackialakshmi Murugan , Ravi Cyril
Published: July 2022

Purpose
Chicken feather is the major waste product of poultry industry that persists in the environment and has become a serious pollutant across the globe. The present study was aimed to check the effect of pretreatment of chicken feather on the keratinolytic potential of chosen bacteria (Glutamicibacter arilaitensis).
Methods
Chicken feathers were pretreated with 0.1N HCl (strong acid) and 0.1N NaOH (strong base) for 48 hours and then provided as substrate for the bacteria cultured in shake flasks and fermentor. In both categories, parameters such as pH, bacterial growth, bacterial biomass, protein and aminoacid concentration along with protease assay were studied. Further, smears of the two media were prepared and observed microscopically upto 120 hours at 24 hours interval. Antibiotic sensitivity test was performed for bacterial culture.
Result
The optimum growth and proteolytic activity (24.94 ± 0.19 U/ml) of G. arilaitensis was observed at 72 hours. The concentration of protein (0.49 mg/ml) and amino acid (3.4 mg/ml) was higher in alkali pretreated feather than acidic treatment in both medium. G. arilaitensis was sensitive to antibiotics such as tetracycline, erythromycin, rifampcin, chloramphenicol and streptomycin, however, it was resistant to penicillin and ampicillin.
Conclusion
It has been found out that, G. arilaitensis was more effective in degrading alkali pretreated feather under fermentation and feather waste can be recycled and converted into valuable products.
Superior mesenteric vein thrombosis in a patient with immune thrombocytopenia: case report and review of literature
Authors: Woo Youngje , Kim Jang Yong
Published: July 2022

Background: Immune thrombocytopenia (ITP) is an acquired autoimmune disorder that has a combination of suppressed platelet production and immune-mediated platelet destruction. Despite the presence of thrombocytopenia, chronic ITP patients have a higher risk of arterial or venous thromboembolism compared to normal people.Case presentation: A 37-year-old female with a history of steroid-resistant chronic ITP presented with severe abdominal pain and massive hematochezia. Upper GI bleeding was diagnosed through nasogastric tube aspiration and esophagogastroduodenoscopy. An abdominal CT scan revealed extensive superior mesenteric vein thrombosis, and small bowel and liver ischemia. She had undergone surgical thrombectomy and small bowel resection. During the hospitalization, she was treated with steroid therapy as well as anticoagulants. Eventually, she required a splenectomy because of a consistent low platelet count. Her platelet count is now stable, and she no longer requires any therapeutic interventions for ITP.Conclusions: This case is one of the few cases that was reported as paradoxical venous thrombosis in ITP patients. Although arterial and venous thrombosis are considered a rare but potentially life-threatening complication of ITP, the therapeutic approach is challenging due to the lack of recommendations and guidelines on the treatment of thrombosis in ITP patients.
The effect of endoscopic transsphenoidal somatotroph tumors resection on pituitary hormones: systematic review and meta-analysis
Authors: Nie Ding , Fang Qiuyue , Wong Wakam , Gui Songbai , Zhao Peng , Li Chuzhong , Zhang Yazhuo
Published: July 2022

Purpose
Currently, endoscopic transsphenoidal surgery is the main treatment for pituitary neuroendocrine tumors (PitNets). Excision of the tumor may have positive or negative effects on pituitary endocrine function and the pituitary function of somatotroph tumors is a point of particular concern after the operation. This study aimed to conduct a meta-analysis on the effect of endoscopic transsphenoidal somatotroph tumor resection on pituitary function.
Methods
A systematic literature search was conducted for articles that included the evaluation of pituitary target gland before and after endoscopic transsphenoidal pituitary adenoma resection and published between 1992 and 2022 in PubMed, Cochrane, and Ovid MEDLINE.
Results
68 studies that included biochemical remission rates in 4524 somatotroph tumors were concluded. According to the 2000 consensus, the biochemical remission rate after transsphenoidal endoscopic surgery was 66.4% (95%CI,0.622–0.703; P = 0.000), the biochemical remission rate was 56.2% according to the 2010 consensus (95%CI,0.503–0.620; P = 0.041), and with the rate of biochemical remission ranging from 30.0–91.7% with investigator's definition. After endoscopic resection, adrenal axis dysfunction was slightly higher than that before surgery, but the difference was not statistically significant. Hypothyroidism was 0.712 times higher risk than that before surgery(OR = 0.712; 95%CI, 0.527–0.961; P = 0.027). Hypogonadism was 0.541 times higher risk than that before surgery (OR = 0.541; 95%CI,0.393–0.746; P = 0.000). Hyperprolactinemia was 0.131 times higher risk than that before surgery (OR = 0.131; 95%CI,0.022–0.783; P = 0.026). The incidence of pituitary insufficiency was 1.344 times risk before surgery after endoscopic resection of somatotroph tumors, but the difference was not statistically significant.
Conclusions
Although the biochemical response rate of patients with transsphenoidal endoscopic growth hormone tumor resection will be increased as endoscopic surgery matures, some patients still require postoperative treatment, including gamma-ray therapy or drug take-in. Long-term follow-up and drug replacement therapy are required for newly diagnosed pituitary dysfunction, while the existing preoperative hypophysis can be ameliorated to some extent.
Unveiling photon statistics with a 100-pixel photon-number-resolving detector
Authors: Cheng Risheng , Zhou Yiyu , Wang Sihao , Shen Mohan , Taher Towsif , Tang Hong
Published: July 2022

Single-photon detectors are ubiquitous in quantum information science and quantum sensing. They are key enabling technologies for numerous scientific discoveries and fundamental tests of quantum optics. Photon-number-revolving detectors are the ultimate measurement tool of light. However, few detectors to date can provide high-fidelity photon number resolution at few-photon levels. Here, we demonstrate an on-chip detector that can resolve up to 100 photons by spatiotemporally multiplexing an array of superconducting nanowires along a single waveguide.
The unparalleled photon number resolution paired with the high-speed response exclusively allows us to unveil the quantum photon statistics of a true thermal light source for the first time, which is realized by direct measurement of high-order correlation function g(N) with N up to 15, observation of photon-subtraction-induced photon number enhancement, and quantum-limited state discrimination against a coherent light source. Our detector provides a viable route towards various important applications, including photonic quantum computation and quantum metrology.
Complete Genome Analysis of Bacillus Velezensis ES2-4: A Novel BacillusStrain with Potential for Biofitilizer and Biocontrol Agent
Authors: Liu Feng , He Qun , Li Wei , Wu Maohua , He Bing
Published: July 2022

Bacillus velezensis is a new species of Bacillus sp recently discovered. It is considered a new plant growth promoting rhizobacteria because of its ability to inhibit a variety of pathogens and promote plant growth. In this study, we isolated a novel Bacillus velezensis strain ES2-4 in orchard soil. Based on comparative analysis, including average nucleotide polymorphism (ANI), digital DNA-DNA hybridization (dDDH), and phylogenetic analysis, ES2-4 was designated as Bacillus velezensis. Genomic analysis revealed that Bacillus velezensis contains a series of genes closely related to promoting plant growth directly and indirectly. Genomic secondary metabolite analyses indicated there are 9 identified gene clusters involved in the biosynthesis of various secondary metabolites (Surfactin, Iturin, Fengycin, Bacillibactin, Bacilysin, Macrolactin, Bacillaene, Difficidin, Amylocyclicin), and five clusters encoding polyketides, lanthipeptide, terpenes, but the specific substances are unclear. In addition, Bacillus velezensis ES2-4 showed good antagonistic activity against various plant pathogens, especially Rhizoctonia solani. These findings suggest that Bacillus velezensis ES2-4 could be used as a PGPR strain to develop new biofertilizers and biocontrol agents.
Long-Term Outcomes of Sleeve Gastrectomy in Adolescent Patients: The Effect of Weight Loss in Younger Years to Outcomes in Adulthood
Authors: Sabah Salman Al , Haddad Eliana Al , Shuaibi Sameera , Qahdi Iman , Al-Saidan Lulwah , Khayat Ali
Published: July 2022

Background
Childhood obesity is associated with a variety of complications that see their light throughout adulthood. Due to the serious side effects of these morbidities, early intervention is essential. Laparoscopic sleeve gastrectomy (SG) is a safe and effective procedure for the treatment of obesity, however, the long-term data on its use in adolescents is lacking in the literature.
Methods
A retrospective analysis was conducted on all patients that underwent SG aged between 12–21 years old at a public hospital in Kuwait. Data on their weight and comorbidities was collected and analyzed.
Results
164 adolescent patients with a mean age of 19 underwent SG. 71% of the patients were female, while the mean weight at surgery was 128.6 kg, corresponding to a BMI of 47.8 Kg/m2. 32% of patients were classified as BMI more than 50, while 6.7% had a BMI over 60. The highest weight loss was achieved at 18 months post-op, corresponding to an EWL of 82.66%. On long-term follow-up, weight loss was maintained over the 13 years post-op. Obstructive sleep apnea was resolved in 75% of the patients. While hypertension remained in the 2 patients that presented with it pre-op. 21 patients developed gastro-esophageal reflux disease 5.7 years post-op, while 20 patients were treated for gall bladder stones 4.4 years post-op.
Conclusion
It is of ample importance to tackle obesity during childhood, before complications ensure later in life. Bariatric surgery, specifically SG, has been found to be an effective and safe weight loss tool, with sustained long-term weight and resolution of early comorbidities.
miR-138-5p-mediated HOXD11 promotes cell invasion and metastasis by activating the FN1/MMP2/MMP9 pathway and predicts poor prognosis in penile squamous cell carcinoma
Authors: Tan Xingliang , Wang Yanjun , Wu Zhingming , Zou Yuantao , Luo Sihao , Tang Yi , Chen Dong , Yuan Gangjun , Yao Kai
Published: July 2022

Background
Regional lymph node and distant metastasis are the most radical causes of high mortality in penile squamous cell carcinoma (PSCC) patients. However, the available biomarkers and detailed mechanisms underlying the metastasis of PSCC remain elusive. Here, we detected that HOXD11 was upregulated in tumors, especially in metastatic lymph nodes, highlighting its role in the progression of PSCC. We aimed to further explore the clinical significance, biofunctions and specific mechanisms of HOXD11.
Methods
Twelve PSCC tumors, metastatic lymph nodes and corresponding normal tissue pairs were examined by an RNA-seq panel of HOX genes to explore progressive biomarkers. The expression of HOXD11 was detected by qPCR and western blotting in our newly established PSCC cell lines. The clinical relevance and outcomes of HOXD11 were further validated in a large cohort of 267 PSCC patients by immunohistochemistry. Functional experiments in vitro and subcutaneous xenograft and footpad metastatic models were conducted to investigate the of HOXD11. The targeting relationship and mechanisms between HOXD11, miR-138-5p and FN1 were demonstrated by dual luciferase reporter assays and chromatin immunoprecipitation.
Results
HOXD11 expression was upregulated in PSCC tissues, especially in metastatic lymph nodes. High HOXD11 expression was associated with aggressive features, such as advanced pN stages, extranodal extension, pelvic lymph node and distant metastasis, and predicted poor survival. Furthermore, knockdown of HOXD11 not only inhibited cell proliferation, invasion and tumor growth but also reduced the burden of metastatic lymph nodes. Besides, miR-138-5p and FN1 reversed HOXD11-mediated oncogenic capacity. Mechanistic studies indicated that HOXD11 was post-transcriptionally regulated by miR-138-5p, bound to the promoter regions of FN1 activating the FN1/MMP2/MMP9 pathway to decompose the extracellular matrix and promoted epithelial mesenchymal transition-like phenotype metastasis.
Conclusions
HOXD11 promotes PSCC progression, predicting advanced disease with poor outcomes. HOXD11 could be a promising prognostic biomarker and potential therapeutic target for PSCC.
The relationship between Serous choroidal detachment and Ahmad Glaucoma Valve Failure; a Coarsened Exact Matched Study
Authors: Yadgari Maryam , Vafaei Fatemeh , Attarian Behnoosh , Hatami Mehdi , Hooshmandi Sadid
Published: July 2022

Background
Several factors affect the surgical success ofَAhmed Glaucoma Valve (AGV) implantation. Choroidal detachment (CD) remains a common complication after filtering surgeries. In the present study, we aimed to investigate the effect of choroidal detachment on the success of AGV.
Methods
In this case-control study, patients who underwent AGV implantation and developed CD were included as a case group. A control group matched for age, sex, systemic disease, lens status, baseline IOP, glaucoma type, and the number of previous glaucoma surgeries using coarsened exact matching were also included. The patients’ data, including intraocular pressure (IOP), number of glaucoma medications, and complications, were retrospectively extracted from the patients’ records. The primary outcome was the AGV success rate 5 < IOP < 18 and a 20-percent reduction from the baseline. IOP and Glaucoma medications were considered secondary outcomes.
Results
Seventeen patients were enrolled as a case group, and 38 matched individuals were included as controls. The average age of participants was 53.2 ± 16.2 years. Preoperative visual acuity of patients was 1.3 ± 0.8 logMAR. The patients in the case group showed higher IOP in all time intervals. However, the average IOP only reached a statistically significant difference at month 3 (17.94 ± 6.78 vs. 13.39 ± 3.09, P = 0.003). The mean survival duration was significantly shorter in patients with CD (10.4 ± 0.7 months vs. 11.7 ± 0.2 for controls LogRANK = 4.1, P = 0.04). In total patients, the cumulative probability of success was 98.2% and 89.1% in months 3 and 6.
Conclusion
Choroidal detachment after AGV implantation could be a risk factor for failure after 12 months. The patients experiencing CD in the postoperative period had significantly lower survival duration. A larger prospective with a longer follow-up duration is required to confirm the present study results.
Structural and photoluminescence properties of cyan blue novel Sr0.90-xMg0.10Al12O19:Ndxnanophosphor
Authors: Kurmi Swati , Verma Akshkumar , Litoriya Praveen Kumar , Verma Ashish , Sahu Ishwar Prasad , Kumar Ravinder
Published: July 2022

Magnesium aluminates-based nanophosphors have been synthesized using the combustion reaction, where Nd3+ were varied from 0 to 0.075 molar concentrations. SrMgAl12O19:Nd3+ was studied for its morphology, structure, and photoluminescence properties. The XRD patterns from all samples were well correlated with the standard XRD pattern of SrAl12O19 (JCPDS File No. 89-2505). A study using energy dispersive X-ray spectroscopy (EDS) demonstrated the presence of all the expected elements in the configuration.A scanning electron microscopy study revealed that the surfacemorphologychanged as the concentration of Nd3+ increased. PL Spectroscopic measurements of Nd3+ ions at 475 (cyan) and 575 (yellow) nm have been made by directly exciting them at 350 nm, corresponding to 4D3/2 + 4D5/2,2P1/2, → 4F3/2 transitions, respectively. Results from color coordinates provided by the (CIE 1931) indicate that the cyan blue emission color originates from the synthesized phosphor.
Gender differential prevalent of overweight and obesity, hypertension and diabetes in South India: A population-based cross-sectional study
Authors: Mohanraj Sundaresan , Velmurugan Ganesan , Dhivakar Mani , Ramakrishnan Arulraj , Cherian Mathew , Alexander Thomas , Thalappil Pradeeep , Swaminathan Krishnan
Published: July 2022

India is facing triple epidemic of Non communicable diseases including high bodymass index, high blood pressure and high blood glucose, that contributing more than half of deaths of all mortality. We investigated the gender specific burden of overweight/obesity, hypertension, diabetes and multimorbidity and their associated risk factors in rural, sub-urban and urban in Tamil Nadu, India. A total of 2976 participants were involved in this study, whereby 865 were rural, 1030 were sub-urban and 1081 were urban population. Overweight and obesity were higher in urban residents (47.5%) compared with rural (31.4%) and sub-urban (34.1%). The prevalence of hypertension was higher in sub-urban (47.1%) than in rural (36.4%) and urban (39.7%), but the mean systolic and diastolic blood pressure were higher in rural than in sub-urban and urban participants. In sub-group analysis, the prevalence of hypertension was higher in both men and women (53.5% and 41.7%) in sub-urban compared with rural (41.9% and 31.3%) and urban (45.9% and 35.5%). The prevalence of diabetes was higher in sub-urban (25.8%) than rural (16.1%) and urban (23%). Diabetes and hypertension was the most common combination of comorbidity in all the three demographical areas. Comparatively, higher prevalence of multimorbidity was found in sub-urban and urban residents than in rural residents. Our data highlight the urgent need for systematic studies to understand the cardiovascular risk factors phenotype and novel environmental risk factors that are associated with overweight/obesity, hypertension and diabetes in all different demographical areas in India.
In vitro and in vivo biochemical activities of novel copper complexes of chrysin derivatives of organosulfur compounds based potential therapeutic agent: design, synthesis, characterization and pharmacological studies
Authors: Ebenezer B. , Nagashri K.
Published: July 2022

Novel series of chrysin compound containing the organosulfur moiety from the Schiff bases derived from chrysin and 2-(phenylthio)aniline and their copper complexes were synthesized. They were characterized using analytical and spectral techniques. All the Cu(II) complexes exhibit the distortion square planar geometry. The in vitro antimicrobial activities of the investigated compounds were tested against the bacterial species, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, and Klebsiella pneumoniae and fungal species, Aspergillus niger, Fusarium solani, Rhizoctonia bataicola and Candida albicans by disc diffusion process. Free radical scavenging, superoxide dismutase, glutathione peroxidase and antioxidant activities of the copper complexes have also been studied. The DNA-cleavage activities of Cu(II) complexes, have been investigated by using agarose gel electrophoresis. Furthermore, interaction of copper complexes with bovine serum albumin was investigated by fluorescence spectrometry. The anticancer activities of the complexes have been carried out towards HeLa and HCT116 cancer cells. The pretreatment of chrysin compounds containing the organosulfur moiety of Cu(II) complexes ([CuHL4l(OAc)], [CuHL4m(OAc)] and [CuHL4n(OAc)]) elicited marked anti-inflammtory effects in carrageenan induced paw edema test in mice during various assessment times (1–5 hrs).
Starvation and Relubrication in Oscillating Bearings - Influence of Grease Parameters
Authors: Wandel Sebastian , Bader Norbert , Leckner Johan , Lehnhardt Bela , Glodowski Jakob , Poll Gerhard
Published: July 2022

A common application for grease-lubricated oscillating rolling element bearings are, e.g., rotor blade bearings in wind turbines. These bearings mainly operate under low-velocity conditions leading to starvation. If the grease is unable to provide enough inlet lubricant supply for the contact between rolling element and bearing raceway, wear in the form of False Brinelling and thus premature bearing failure is possible. Bearing experiments with different lithium complex model greases, which differ mainly in their base oil viscosity and oil separation rate, were carried out to show the influence of the grease parameters on wear initiation. The results show that the ability of the grease to release a high amount of base oil with high mobility into the track of the rolling element is a crucial mechanism to prevent wear, especially at small oscillation angles. For oscillation angles larger than a critical angle, a secondary replenishment mechanism may prevent early wear initiation. The experimental results are used to validate a starvation model proposed in earlier work [1].
Scope and Challenges of Incorporating Citizen Science into Indian Higher Education Institutions: A Case Study
Authors: PHARTYAL Shyam S. , Yadav Harsh
Published: July 2022

Citizen Science (CS) is gaining popularity among a section of the Indian Research Community as a potential cost-effective tool to generate and gather large-scale temporospatial-distributed research data with the help of non-scientist citizens ready to volunteer their free time for science and societal issues. However, CS activities in India seem confined to a few selected research disciplines at selected geolocations. This poses challenges and scope to incorporating CS into all Indian Higher Education Institutions (HEIs) as an experimental learning tool. We conducted a pan-India, online survey and assessed the scope and challenges of CS in Indian HEIs. The survey recorded the perception of all stockholders irrespective of their academic and professional background for four months, from January to May 2021. Survey results revealed explicit geographical and research discipline-wise biases in participants' acquaintance and preference for CS. Agriculture/Biodiversity/Ecology/Environment Science disciplines recorded around 67% of responses. More than two-thirds of respondents conveyed their interest in CS. However, they highlighted the lack of hand-on-experience and opportunity for formal training on CS at schools/university levels. The study emphasized the inclusion of the CS curriculum in the mainstream education system to train the next generation of researchers on several aspects of CS and tap its potential for large-scale research studies in all higher education disciplines.
Model of the relationship of religiosity and happiness of Multiple Sclerosis patients from Poland. Role of mediating and moderating variables
Authors: Wnuk Marcin , Wilski Maciej , Brola Waldemar , Żak Marek , Sobolewski Piotr , Kapica-Topczewska Katarzyna , Tarasiuk Joanna , Czarnowska Agata , Kułakowska Alina , Zakrzewska-Pniewska Beata , Kubicka-Bączyk Katarzyna , Morawiec Natalia , Adamczyk-Sowa Monika , Stępień Adam , Zaborski Jacek , Ratajczak Anna , Ratajczak Marcin , Szałachowski Roman , Szcześniak Małgorzata , Kroplewski Zdzisław , Bartosik-Psujek Halina , Lech Beata , Perenc Adam , Popiel Małgorzata , Potemkowski Andrzej
Published: July 2022

Religiosity can be both beneficial and harmful for happiness. It depends on its operationalization and the measures of religiosity and sociodemographics used, together with cultural and psychosocial factors – still not comprehensively explored. This topic is especially important for religious-affiliated chronic patients such as those diagnosed with Multiple Sclerosis. Religion can deliver a sense of meaning, direction, and purpose in life and be an additional source of support and coping with the stress and limitations connected with the disease. The aim of the present study was to verify whether religiosity, directly and indirectly, through finding meaning in life, is related to one’s level of happiness and whether gender, drinking of alcohol, financial status and age are moderators in this relationship. In sum, 600 patients from Poland who suffered from Multiple Sclerosis were included in the study. Firstly, some gender differences were noticed. In women, religiosity was both directly and indirectly, through finding significance, positively related to happiness. Secondly, it was found that in women, the direct effect of age on happiness was generally negative but affected positively by religiosity but among men age was not correlated with happiness. In the group of women, religiosity and a lower propensity to drink alcohol in an interactive way explained happiness. Thirdly, both in men and women, financial status positively correlated with happiness, but in the group of wealthy men only, religiosity was negatively related to happiness. In conclusion, religion was found to be a valuable and beneficial factor leading to the happiness of Roman Catholic Multiple Sclerosis patients from Poland. They should be encouraged to involve themselves in religion as an effective way to achieve happiness, with the one exception regarding wealthy men.
Optimizing lactic acid production for agricultural wastes revalorization via sugars hydrothermal conversion with zirconia-based catalysts: response surface methodology
Authors: Piovano Federico A , Aspromonte Soledad , Gross Martin S , Bergamini Carina , Boix Alicia V
Published: July 2022

The hydrothermal conversion of a complex sugars solution comprising glucose, arabinose and xylose with zirconia-based catalysts to produce lactic acid (LA) was studied. Catalysts were synthesized by a simple template-assisted sol-gel method. Alternative template removal procedures, such as refluxing ethanol extraction, were compared to the conventional direct calcination. Acidic properties of catalysts were determined by two different techniques, pyridine temperature-programmed desorption and potentiometric titration with n-butylamine. The extracted catalyst reported the highest specific surface area (323 m2 g-1), total pore volume (0.21 cm3 g-1), and density of acid sites (1.111 µmol m-2) with a significant contribution of strong acid sites. On the other hand, the thermal treatment transformed the hydrous zirconia into crystalline tetragonal phase, reducing the specific surface area and removing most of the acid sites. A four factors experimental design was performed and analyzed by means of response surface methodology (RSM) to maximize the LA production with the extracted catalyst. A molar yield of 61.2 % towards LA and complete sugars conversion were reached at optimal operating conditions: 189 °C, 208 min, 0.5 g catalyst g-1 reactants and 10 bar N2. Additionally, fitting models for main by-products molar yields (furans, glyceraldehyde, glycolic, formic, acetic and levulinic acids) were obtained with good accuracy prediction. All responses were jointly studied to understand the reaction mechanisms involved in generation of intermediaries and undesired degradation products.
Effectiveness of parenting training in mothers with a borderline personality disorder: A multiple baseline single-case experimental design study
Authors: Vigeveno¹ Daan. E. , Maric Marija , Onghena Patrick , Hupkes Monique
Published: July 2022

Background: Parents with borderline personality disorder (BPD) experience deficiencies in parenting skills leading to increased family burden and stress, mental health problems in children and even family violence. The present study evaluated the effectiveness of a Dutch version of the parenting training based on Dialectical Behaviour Therapy (DBT) for mothers with BPD developed by Renneberg and Rosenbach (2016). Methods: Given the high heterogeneity found in patients with BPD, a multiple baseline single-case experimental design study was conducted with standardised and idiosyncratic assessments of parenting behaviour and parental stress before, biweekly during, and after the training. Participants (N=10; mean age = 35.9, SD = 4.65) were mothers with a full diagnosis of BPD with at least one child under the age of 6 at the start of the training.Results: Four participants discontinued the training. Among the six training completers, clinically reliable improvements in parenting skills between pre- and post-/follow-up training were most pronounced for inconsistent discipline, involvement, positive parenting and corporal punishment. Frequent, idiosyncratic assessments showed that for all six mothers the DBT training had positive effect on parenting skills, while for five mothers this effect was large. Positive changes in parenting stress were found in three (post) to four (follow-up) participants. Positive changes in parenting behaviour were also found for the four training non-completers. Participants were satisfied with the training.Conclusions and implications: DBT parenting training has a great clinical value for mothers with BPD struggling with raising their children. In our effectiveness study, we found empirical evidence to confirm this clinical impression. Through tentative investigation of individual effects among the six training completers, we learned that, in comparison to other mothers, mothers with comorbid PTSD (N = 3) show almost no changes in the levels of parenting stress after the training. The mothers with most positive results received anti-depressants and had clear arrangements about the role of partners in the family. The complexity and heterogeneity of the condition requires a more idiosyncratic approach. Mothers with BPD could profit from more stress management regarding parenting and increasing commitment to participation in DBT parenting training.This study was registered (retrospectively) in ISRCTN (ID ISRCTN74447767).https://www.isrctn.com/ISRCTN74447767, March 2022
Public perceptions on routine use of screening tools for domestic abuse in health and social care settings: an exploratory cross-sectional study
Authors: Sivarajasingam Vasumathy , Webber Iman , Karki Manisha , Bagkeris Emmanouil , Alaa Aos , Asmar Marie Line El , Sasco Eva Riboli , El-Osta Austen
Published: July 2022

Background
Domestic violence and abuse (DVA) is a rising societal concern with increased prevalence since the national lockdowns and remains largely under-detected by the medical community. Although screening increases early detection of abuse, current NICE guidelines which were produced before the advent of COVID-19 do not recommend routine DVA screening in primary care. Little is known about patient views regarding DVA screening in UK primary care. This exploratory survey assesses the public’s experiences and their views on routine DVA screening.
Methods
An open, easily accessible anonymous 27-item eSurvey made available on the Imperial College London Qualtrics platform between 8 March and 27 September 2021 was used to collect data from community dwelling adults. Potentially eligible participants were contacted via email through community groups in Northwest London catchment area, and using adverts on social media. The survey targeted a wider population in the community, including those who were 18 years and over, living in the UK and spoke English. The eSurvey also included information on accessible support services. Data were summarised using frequencies and percentages. Regression analysis explored the association between WAST-short questions and previous exposure to abuse.
Results
Data from 298 community-dwelling adults was analysed. A third of respondents confirmed having experienced DVA, and another 6.4% declined disclosure. The univariable analysis suggested that those with a history of abuse compared to those with no history were 11 times more likely to have tension in the relationship and nine times more likely to have difficulty working out arguments. After adjusting for a-priori confounders (age, gender and ethnicity), those who answered ‘would rather not say’ appeared to be 34 times more likely to have tension in the relationship, and 17 times more likely to have difficulty working out arguments. Nearly two-thirds of the study population recommended routine screening in general practice using a short-validated tool.
Conclusion
The routine use of the already established screening tool such as WAST-short in primary care could help identify and potentially tackle DVA in our society. Training health and social care professionals in administering the brief, non-threatening DVA screening questionnaire would help raise awareness, identify and support victims.
Association Between Competencies of Biopsychosocial Approach and Job Satisfaction of Rehabilitation Professionals in Ukraine
Authors: Klavina Aija , Ng Kwok , Lazareva Olena , Mruga Marina , Tymruk-Skoropad Kateryna , Rokutov Serhii , Bazylchuk Oleh , Zakalyak Nataliia , Billiet Lorenzo , Cizh Lubov , Popovych Dariya , Myndziv Kateryna , Yezhova Olha
Published: July 2022

The Biopsychosocial (BPS) model is recognized and widely accepted in the field of health care, particularly in rehabilitation. However, in clinical practice the applicability of the BPS model is a challenge for many professionals. Method. This study aimed to explore the factors that impact the perception of rehabilitation professionals about the BPS model in Ukraine. In addition, the job satisfaction assessment was done to measure whether rehabilitation specialists in Ukraine fulfil their professional roles according to their expectations and values. Participants were 346 rehabilitation specialists from Ukraine who completed the Bio-Psycho-Social Scale (BPS) for Use in Healthcare and the Global Job Satisfaction Scale (GJSS). The ANOVA was used to investigate the outcome differences between the two scales. Results. The highest proportion of responders in this study represented state health services. The BPS subscale outcomes on “assessment and reporting” and “professional knowledge and skills” were significantly higher for specialists from a private sector. The global job satisfaction scale outcomes did not differ between responders from the private and state health sector. The perception of professionals networks was associated with greater job satisfaction. Conclusions. The findings suggest that conception of the BPS approach in rehabilitation system of Ukraine varies across the private and state settings. The professional network plays important role in job satisfaction of rehabilitation professionals in Ukraine. Future research focusing on education strategies to effectively train professionals to apply biopsychosocial approach to practice is of critical importance to prepare rehabilitation specialists in Ukraine.