bluuebunny/crossref_metadata_2025 huggingface dataset:
Conditional Knock out of High-Mobility Group Box 1 (HMGB1) in Rods Reduces Autophagy Activation after Retinal Detachment
Authors: Ross Bing X. , Jia Lin , Kong Dejuan , Wang Tiantian , Hager Heather M. , Abcouwer Steven F. , Zacks David N.
Published: August 2021

After retinal detachment (RD), the induction of autophagy protects photoreceptors (PR) from apoptotic cell death. The cytoplasmic high-mobility group box 1 (HMGB1) promotes autophagy. We previously demonstrated that the deletion of HMGB1 from rod PRs results in a more rapid death of these cells after RD. In this work, we tested the hypothesis that the lack of HMGB1 accelerates PR death after RD due to the reduced activation of protective autophagy in the retina after RD. The injection of 1% hyaluronic acid into the subretinal space was used to create acute RD in mice with a rhodopsin-Cre-mediated conditional knockout (cKO) of HMGB1 in rods (HMGB1Δrod) and littermate controls. RD sharply increased the number of apoptotic cells in the outer nuclear layer (ONL), and this number was further increased in HMGB1Δrod mouse retinas. The activation of autophagy after RD was reduced in the HMGB1Δrod mouse retinas compared to controls, as evidenced by diminished levels of autophagy regulatory proteins LC3-II, Beclin1, ATG5/12, and phospho-ATG16L1. The cKO of HMGB1 in rods increased the expression of Fas and the Bax/Bcl-2 ratio in detached retinas, promoting apoptotic cell death. In conclusion, endogenous HMGB1 facilitates autophagy activation in PR cells following RD to promote PR cell survival and reduce programmed apoptotic cell death.
Seagrass Meadows Provide a Significant Resource in Support of Avifauna
Authors: Unsworth Richard K. F. , Butterworth Emma G.
Published: August 2021

Seagrass meadows are known to be rich in fauna, with complex food webs that provide trophic subsidy to species and habitats way beyond the extent of their distribution. Birds are an often-overlooked part of marine ecosystems; not only are they crucial to the health of marine ecosystems, but their populations are also supported by the productivity and biodiversity of marine ecosystems. The links of birds to specific habitat types such as seagrass meadows are largely not considered except in the context of direct herbivorous consumption. Here, we examine the linkages between seagrass and birds and propose a conceptual framework for how seagrasses may support bird populations beyond their distribution in both direct and indirect pathways. We present evidence that seagrass meadows are globally foraged for fish and invertebrates by coastal birds. They are also targeted by herbivorous wildfowl and potentially benefit birds further afield indirectly as a result of their support for offshore marine fish species at critical times in their life cycle (e.g., Atlantic Cod and King George Whiting). Evidence from the literature indicates that seagrass does provide support for birds, but reveals a field of research requiring much gap filling as studies are globally sparse, mechanistically limited, and small in spatial and temporal scales.
Diagnosis and Management of Mixed Transcortical Aphasia Due to Multiple Predisposing Factors, including Postpartum and Severe Inherited Thrombophilia, Affecting Multiple Cerebral Venous and Dural Sinus Thrombosis: Case Report and Literature Review
Authors: Jianu Dragoș Cătălin , Jianu Silviana Nina , Dan Traian Flavius , Iacob Nicoleta , Munteanu Georgiana , Motoc Andrei Gheorghe Marius , Băloi Adelina , Hodorogea Daniela , Axelerad Any Docu , Pleș Horia , Petrica Ligia , Gogu Anca Elena
Published: August 2021

Cerebral venous and dural sinus thrombosis (CVT) is an uncommon disease in the general population, although it is a significant stroke type throughout pregnancy and the puerperium. Studies describing this subtype of CVT are limited. Most pregnancy-associated CVT happen in late pregnancy, or more commonly in the first postpartum weeks, being associated with venous thrombosis outside the nervous system. Case presentation: The current study describes a case of multiple CVT in a 38-year-old woman with multiple risk factors (including severe inherited thrombophilia and being in the puerperium period), presenting mixed transcortical aphasia (a rare type of aphasia) associated with right moderate hemiparesis and intracranial hypertension. The clinical diagnosis of CVT was confirmed by laboratory data and neuroimaging data from head computed tomography, magnetic resonance imaging, and magnetic resonance venography. She was successfully treated with low-molecular-weight heparin (anticoagulation) and osmotic diuretics (mannitol) for increased intracranial pressure and cerebral edema. At discharge, after 15 days of evolution, she presented a partial recovery, with anomic plus aphasia and mild right hemiparesis. Clinical and imaging follow-up was performed at 6 months after discharge; our patient presented normal language and mild right central facial paresis, with chronic left thalamic, caudate nucleus, and internal capsule infarcts and a partial recanalization of the dural sinuses.
Digital Customer Experience Mapping in Russian Premium Banking
Authors: Timokhina Galina , Prokopova Lyubov , Gribanov Yuri , Zaitsev Stanislav , Ivashkova Natalia , Sidorchuk Roman , Skorobogatykh Irina , Shishkin Anatoly , Musatova Zhanna
Published: August 2021

The purpose of this study is to identify, in an era of extensive digitalization, the major opportunities and threats that influence the experiences of digital premium banking customers at key stages of their banking interactions. This study’s conceptual research model combines the content of online questionnaires, completed by a representative sample of 3629 customers, in-depth interviews with heads of premium banking departments, and an audit of customer experiences conducted via Mystery Shopping in 13 Russian banks. The authors formulate four research hypotheses, substantiated by the empirical data and highlight key barriers preventing premium banks from effective digital interactions with their customers. Key opportunities for improving customer experiences are also identified. The theoretical contribution of the research includes the adaptation of an axiological approach to studying digital customers in premium banking. Practical contributions include the Premium Digital Customer Experience Map, designed by the authors as a ready-made tool for planning and improving premium banking services and a tool for performance comparison between competing banks. This study also discusses the authors’ definition of a “digital customer”. It presents a new approach to the Mystery Shopping methodology, including the recruitment of Mystery Shoppers following the three premium banking customer portraits: “saver”, “spender”, and “saver–spender”.
Prioritizing Energy-Intensive Machining Operations and Gauging the Influence of Electric Parameters: An Industrial Case Study
Authors: Sidhu Ardamanbir Singh , Singh Sehijpal , Kumar Raman , Pimenov Danil Yurievich , Giasin Khaled
Published: August 2021

Increasing the energy efficiency of machining operations can contribute to more sustainable manufacturing. Therefore, there is a necessity to investigate, evaluate, and optimize the energy consumed during machining operations. The research highlights a method employed to prioritize the most energy-intensive machining operation and highlights the significance of electric parameters as predictors in power estimation of machining operations. Multi regression modeling with standardized regression weights was used to identify significant power quality predictors for active power evaluation for machining operations. The absolute error and the relative error both decreased when the active power was measured by the power analyzer for each of the identified machining operations, compared to the standard power equation and that obtained from the modeled regression equations. Furthermore, to determine energy-intensive machining operation, a hybrid decision-making technique based on TOPSIS (a technique for order preference by similarity to ideal solution) and DoM (degree of membership) was utilized. Allocation of weights to energy responses was carried out using three methods, i.e., equal importance, entropy weights, and the AHP (analytical hierarchy process). Results revealed that a drilling process carried out on material ST 52.3 is energy-intensive. This accentuates the significance of electric parameters in the assessment of active power during machining operations.
Optimal PMU Placement Technique to Maximize Measurement Redundancy Based on Closed Neighbourhood Search
Authors: Hyacinth Lourdusamy Ramya , Gomathi Venugopal
Published: August 2021

This paper proposes a method for the optimal placement of phasor measurement units (PMUs) for the complete observability of a power system based on the degree of the neighbourhood vertices. A three-stage algorithm is used to determine the minimum number of PMUs needed to make the system observable. The key objective of the proposed methodology is to minimize the total number of PMUs to completely observe a power system network and thereby minimize the installation cost. In addition, the proposed technique also focuses on improving the measurement redundancy. The proposed method is applied on standard IEEE 14-bus, IEEE 24-bus, IEEE 30-bus, IEEE 57-bus and IEEE 118-bus test systems and a hybrid AC/DC microgrid test system. The results obtained are compared with already existing methods in terms of the Bus Observability Index (BOI) and System Observability Redundancy Index (SORI). The results show that the proposed method is simple to implement and provides better placement locations for effective monitoring compared to other existing methods.
Controlling Factors for Organic Carbon Burial in the Late Cretaceous Nenjiang Formation of the Songliao Basin, NE China
Authors: Niu Lu , Gao Yuan , Huang He , Tian Xing , Dong Tian , Yang Qian , Cao Xiaomeng , Wang Chengshan
Published: August 2021

The Songliao Basin (SLB) is a large terrestrial petroliferous basin located in northeastern China. The Nenjiang Formation represents excellent hydrocarbon source rocks for the Daqing oil field. Previous studies have indicated that the oil shale intervals from the first (K2n1) and second (K2n2) members of the Nenjiang Formation were formed in different depositional settings. In this study, we provide a new high-resolution (1 m interval) record from SK-1s core and compile three sets of published datasets from two drilling holes (Zk3389 and LY-1) and a composite outcrop section. According to the total organic carbon (TOC) chemostratigraphy, we have divided three variation cycles spanning from K2n1 to K2n2 and detected three potential oil shale intervals in the Nenjiang Formation. Combined with the productivity, salinity, and oxygenation proxies, we discuss the paleolimnological environmental changes during deposition of the Nenjiang Formation. Our new and compiled records support the model that excellent preservation conditions were associated with the formation of organic-rich sediments in the K2n1, while the productivity was the major controlling factor for organic matter enrichment in the K2n2.
Experimental Investigation of the Dynamic Tensile Properties of Naturally Saturated Rocks Using the Coupled Static–Dynamic Flattened Brazilian Disc Method
Authors: Liu Xinying , Dai Feng , Liu Yi , Pei Pengda , Yan Zelin
Published: August 2021

In a naturally saturated state, rocks are likely to be in a stress field simultaneously containing static and dynamic loads. Since rocks are more vulnerable to tensile loads, it is significant to characterize the tensile properties of naturally saturated rocks under coupled static–dynamic loads. In this study, dynamic flattened Brazilian disc (FBD) tensile tests were conducted on naturally saturated sandstone under static pre-tension using a modified split-Hopkinson pressure bar (SHPB) device. Combining high-speed photographs with digital image correlation (DIC) technology, we can observe the variation of strain applied to specimens’ surfaces, including the central crack initiation. The experimental results indicate that the dynamic tensile strength of naturally saturated specimens increases with an increase in loading rate, but with the pre-tension increases, the dynamic strength at a certain loading rate decreases accordingly. Moreover, the dynamic strength of naturally saturated sandstone is found to be lower than that of natural sandstone. The fracture behavior of naturally saturated and natural specimens is similar, and both exhibit obvious tensile cracks. The comprehensive micromechanism of water effects concerning the dynamic tensile behavior of rocks with static preload can be explained by the weakening effects of water on mechanical properties, the water wedging effect, and the Stefan effect.
Electricity Consumption Forecast of High-Rise Office Buildings Based on the Long Short-Term Memory Method
Authors: Lin Xiaoyu , Yu Hang , Wang Meng , Li Chaoen , Wang Zi , Tang Yin
Published: August 2021

Various algorithms predominantly use data-driven methods for forecasting building electricity consumption. Among them, algorithms that use deep learning methods and, long and short-term memory (LSTM) have shown strong prediction accuracy in numerous fields. However, the LSTM algorithm still has certain limitations, e.g., the accuracy of forecasting the building air conditioning power consumption was not very high. To explore ways of improving the prediction accuracy, this study selects a high-rise office building in Shanghai to predict the air conditioning power consumption and lighting power consumption, respectively and discusses the influence of weather parameters and schedule parameters on the prediction accuracy. The results demonstrate that using the LSTM algorithm to accurately predict the electricity consumption of air conditioners is more challenging than predicting lighting electricity consumption. To improve the prediction accuracy of air conditioning power consumption, two parameters, relative humidity, and scheduling, must be added to the prediction model.
Bark of Siberian Conifers: Composition, Use, and Processing to Extract Tannin
Authors: Fedorov Vladimir S. , Ryazanova Tatyana V.
Published: August 2021

The rational use of natural resources, including the creation of new and improvement of existing technologies in order to reduce the anthropogenic impact on the environment, is currently an important task. This review covers different methods of softwood bark processing. Bark is used for the production of heat-insulating plates, and also as filler in adhesives and composites. In agriculture, it is used as a mulch. Softwood bark is a valuable raw material for chemical processing. Extractive substances of the bark are of particular interest. Among them, phenolic compounds are very important, in particular of tannin nature, which are used as tanning agents in leather production. Bark is used for the isolation of substances with antibacterial activity for pharmaceutical and nutraceutical applications. Aqueous-alkaline solutions, in particular monoethanolamine, are used as an extracting agent. Currently, tannins have been applied into many different fields, including medicine, food, beverage, the manufacture of ink and adhesives, the dye and tanning industry, plastic resins, water purification, and surface coatings. Tanning extracts obtained as a result of extraction are refined by ultrafiltration. The obtained extracts are of high purity. The extraction residue, the so-called tan, is a promising raw material for obtaining a cellulosic product. In addition to the chemical conversion of tan, biotechnological processing is an alternative option. In the process of tan biodegradation by the microscopic Trichoderma fungus, a biological product trichodermin is obtained, which is used to protect plants from phytopathogens.
The Pedogenesis of Soil Derived from Carbonate Rocks along a Climosequence in a Subtropical Mountain, China
Authors: Hu Jin , Ci En , Li Song , Lian Maoshan , Zhong Shouqin
Published: August 2021

Revealing the pedogenesis of soil on carbonate rocks is a key step in determining the boundaries of soil types along a climosequence. However, related research is lacking for a subtropical mountain. In this study, eight pedons were sampled across an elevation gradient (789–2322 m) having large variation in mean annual precipitation (MAP) (1189–1764 mm) and mean annual temperature (MAT) (5.7–14.9 °C). General processes were performed, including physical, chemical, and morphological characterizations, X-ray diffraction (XRD), total elements’ content, and soil classification of the carbonate rock. In the climo-toposequence, the illite had been transformed into illite-smectite below 1300–1500 m of elevation, 1300–1370 mm of MAP, and above 10.5–11.5 °C of MAT, and into vermiculite above this climate. These findings indicated that the effects of temperature on soil mineral transformation had weakened with the gradual increases in elevation. The pedon at 861 m of elevation, 1206 mm of MAP, and 14.5 °C of MAT, which accounted for the argic horizons, was divided into Argosols after human activities. The finding revealed that changes from forest to cultivated land could potentially accelerate the formation of argic horizons, and it provided a theoretical basis for global carbonate rocks’ weathering conditions and ecological problems in subtropical mountains. When the soils reached approximately 1100–1200 m of elevation, 1250–1300 mm of MAP, and 11.5–13.5 °C of MAT, the argic horizons of the soil could be accounted for, as evolved from the Cambosols in Chinese Soil Taxonomy (CST) (Inceptisols in Soil Taxonomy (ST), Cambisols in the World Reference Base for Soil Resources (WRB)) to the Argosols in CST (Alfisols in ST, Luvisols or Alisols in WRB) under natural vegetation. Therefore, it was indicated that the soil types changed significantly in the CST, ST, and WRB with increases of MAP and decreases of MAT, which provides a reference for determining the boundaries of the soil types along a climosequence in subtropical mountains.
Comparison of Four-Dimensional Flow Magnetic Resonance Imaging and Particle Image Velocimetry to Quantify Velocity and Turbulence Parameters
Authors: Kim Doohyeon , Kang Jihun , Adeeb Ehsan , Lee Gyu-Han , Yang Dong Hyun , Ha Hojin
Published: August 2021

Although recent advances of four-dimensional (4D) flow magnetic resonance imaging (MRI) has introduced a new way to measure Reynolds stress tensor (RST) in turbulent flows, its measurement accuracy and possible bias have remained to be revealed. The purpose of this study was to compare the turbulent flow measurement of 4D flow MRI and particle image velocimetry (PIV) in terms of velocity and turbulence quantification. Two difference flow rates of 10 and 20 L/min through a 50% stenosis were measured with both PIV and 4D flow MRI. Not only velocity through the stenosis but also the turbulence parameters such as turbulence kinetic energy and turbulence production were quantitatively compared. Results shows that 4D flow MRI velocity measurement well agreed with the that of PIV, showing the linear regression slopes of two methods are 0.94 and 0.89, respectively. Although turbulence mapping of 4D flow MRI was qualitatively agreed with that of PIV, the quantitative comparison shows that the 4D flow MRI overestimates RST showing the linear regression slopes of 1.44 and 1.66, respectively. In this study, we demonstrate that the 4D flow MRI visualize and quantify not only flow velocity and also turbulence tensor. However, further optimization of 4D flow MRI for better accuracy might be remained.
Linking the Phytochemicals and the α-Glucosidase and α-Amylase Enzyme Inhibitory Effects of Nigella sativa Seed Extracts
Authors: Tiji Salima , Bouhrim Mohamed , Addi Mohamed , Drouet Samantha , Lorenzo Jose Manuel , Hano Christophe , Bnouham Mohamed , Mimouni Mostafa
Published: August 2021

Nigella sativa L. (Ranunculaceae), commonly referred to as black seeds or black cumin, is used in popular medicine (herbal) all over the world for the treatment and prevention of several diseases, including diabetes. This study aims to investigate the inhibitory effect of N. sativa extracts and fractions against the activities of intestinal α-glucosidase and pancreatic α-amylase in vitro, and to explain the inhibitory effect of these fractions against these enzymes by identifying their active compounds responsible for this effect and determine their modes of inhibition. To do so, N. sativa hexane and acetone extracts were prepared and analyzed by GC–MS and HPLC–DAD, respectively. The hexane extract was further fractioned into eight different fractions, while the acetone extract generated eleven fractions. The extracts as well as the resulting fractions were characterized and evaluated for their potential in vitro antidiabetic activity using intestinal α-glucosidase and pancreatic α-amylase inhibitory assays in vitro. Hexane extract and fractions were less active than acetone extract and fractions. In the case of intestinal α-glucosidase activity, the acetone fraction SA3 had a high inhibitory effect on intestinal α-glucosidase activity with 72.26 ± 1.42%, comparable to the effect of acarbose (70.90 ± 1.12%). For the pancreatic α-amylase enzymatic inhibitory assay, the acetone fractions showed an inhibitory capacity close to that for acarbose. In particular, the SA2 fraction had an inhibitory effect of 67.70 ± 0.58% and was rich in apigenin and gallic acid. From these fractions, apigenin, (−)-catechin, and gallic acid were further characterized for their inhibitory actions. IC50 and inhibition mode were determined by analyzing enzyme kinetic parameters and by molecular modeling. Interestingly, (−)-catechin showed a possible synergistic effect with acarbose toward α-glucosidase enzyme inhibition, whereas apigenin showed an additive effect with acarbose toward α-amylase enzymatic inhibition. Furthermore, we studied the toxicity of N. sativa hexane and acetone extracts as well as that of acetone fractions. The result of acute toxicity evaluation demonstrated that N. sativa extracts were nontoxic up to a concentration of 10 g/kg, except for fraction SA3. Taken together, these results indicate that N. sativa extracts and/or derived compounds could constitute promising nutraceuticals for the prevention and treatment of type 2 diabetes mellitus.
Coat Color-Facilitated Efficient Generation and Analysis of a Mouse Model of Down Syndrome Triplicated for All Human Chromosome 21 Orthologous Regions
Authors: Li Yichen , Xing Zhuo , Yu Tao , Pao Annie , Daadi Marcel , Yu Y. Eugene
Published: August 2021

Down syndrome (DS) is one of the most complex genetic disorders in humans and a leading genetic cause of developmental delays and intellectual disabilities. The mouse remains an essential model organism in DS research because human chromosome 21 (Hsa21) is orthologously conserved with three regions in the mouse genome. Recent studies have revealed complex interactions among different triplicated genomic regions and Hsa21 gene orthologs that underlie major DS phenotypes. Because we do not know conclusively which triplicated genes are indispensable in such interactions for a specific phenotype, it is desirable that all evolutionarily conserved Hsa21 gene orthologs are triplicated in a complete model. For this reason, the Dp(10)1Yey/+;Dp(16)1Yey/+;Dp(17)1Yey/+ mouse is the most complete model of DS to reflect gene dosage effects because it is the only mutant triplicated for all Hsa21 orthologous regions. Recently, several groups have expressed concerns that efforts needed to generate the triple compound model would be so overwhelming that it may be impractical to take advantage of its unique strength. To alleviate these concerns, we developed a strategy to drastically improve the efficiency of generating the triple compound model with the aid of a targeted coat color, and the results confirmed that the mutant mice generated via this approach exhibited cognitive deficits.
Mitogenome Phylogeny Including Data from Additional Subspecies Provides New Insights into the Historical Biogeography of the Eurasian lynx Lynx lynx
Authors: Mengüllüoğlu Deniz , Ambarlı Hüseyin , Barlow Axel , Paijmans Johanna L. A. , Sayar Ali Onur , Emir Hasan , Kandemir İrfan , Hofer Heribert , Fickel Jörns , Förster Daniel W.
Published: August 2021

Previous molecular studies of the wide-ranging Eurasian lynx Lynx lynx focused mainly on its northern Palearctic populations, with the consequence that the reconstruction of this species’ evolutionary history did not include genetic variation present in its southern Palearctic distribution. We sampled a previously not considered Asian subspecies (L. l. dinniki), added published data from another Asian subspecies (L. l. isabellinus), and reassessed the Eurasian lynx mtDNA phylogeny along with previously published data from northern Palearctic populations. Our mitogenome-based analyses revealed the existence of three major clades (A: Central Asia, B: SE Europe/SW Asia, C: Europe and Northern Asia) and at least five lineages, with diversification in Lynx lynx commencing at least 28kyr earlier than hitherto estimated. The subspecies L. l. isabellinus harbors the most basal matriline, consistent with the origin of Lynx lynx in this subspecies’ current range. L. l. dinniki harbors the second most basal matriline, which is related to, and may be the source of, the mtDNA diversity of the critically endangered Balkan lynx L. l. balcanicus. Our results suggest that the Anatolian peninsula was a glacial refugium for Eurasian lynx, with previously unconsidered implications for the colonization of Europe by this species.
Analysis of DRD2 Gene Polymorphism in the Context of Personality Traits in a Group of Athletes
Authors: Chmielowiec Krzysztof , Michałowska-Sawczyn Monika , Masiak Jolanta , Chmielowiec Jolanta , Trybek Grzegorz , Niewczas Marta , Czarny Wojciech , Cieszczyk Paweł , Massidda Myosotis , Proia Patrizia , Grzywacz Anna
Published: August 2021

The presented study showed the relationship between dopamine receptor gene polymorphism and personality traits in athletes training in martial arts. Behavioral modulation resulting from a balance of the neurotransmitters dopamine and norepinephrine to inactivation of the dorsolateral prefrontal cortex and dysregulation of various pathways involved in attention and impulse control processes; Methods: The study was conducted among martial arts athletes. The study group included 258 volunteers and 284 controls. The genetic test was performed using the real-time PCR method; psychological tests were performed using standardized TCI questionnaires. All analyses were performed using STATISTICA 13. Results: Interaction between martial arts and DRD2 rs1799732 (manual) G/-(VIC/FAM)-ins/del and RD- Harm avoidance and Reward Dependence scale were demonstrated. In athletes, a lower Reward Dependence scale score was associated with the DRD2 rs1799732 (manual)-/-polymorphism compared to the control group. Conclusions: It seems justified to study not only genetic aspects related to brain transmission dopamine in martial arts athletes. In the studied athletes, the features related to reward addiction and harm avoidance are particularly important in connection with the dopaminergic reward system in the brain.
Slope Failure in a Period of Increased Landslide Activity: Sennwald Rock Avalanche, Switzerland
Authors: Aksay Selçuk , Ivy-Ochs Susan , Hippe Kristina , Grämiger Lorenz , Vockenhuber Christof
Published: August 2021

The Säntis nappe is a complex fold-and-thrust structure in eastern Switzerland, consisting of numerous tectonic discontinuities and a range of hillslopes prone to landsliding and large slope failures that modify the topography irreversibly. A slope failure, namely the Sennwald rock avalanche, occurred in the southeast wall of this fold-and-thrust structure due to the rock failure of Lower Cretaceous Helvetic limestones along the Rhine River valley. In this research, this palaeolandslide is examined in a multidisciplinary approach for the first time with detection and mapping of avalanche deposits, dynamic run-out modelling and cosmogenic nuclide dating. During the rock failure, the avalanche deposits were transported down the hillslope in a spreading-deck fashion, roughly preserving the original stratigraphic sequence. The distribution of landslide deposits and surface exposure age of the rock failure support the hypothesis that the landslide was a single catastrophic event. The 36Cl surface exposure age of avalanche deposits indicates an age of 4.3 ± 0.5 ka. This time coincides with a notably wet climate period, noted as a conditioning factor for landslides across the Alps in the mid-Holocene. The contemporaneity of our event at its location in the Eastern Alps provide additional support for the contention of increased regional seismic activity in mid-Holocene.
Healthcare Digitalisation and the Changing Nature of Work and Society
Authors: Sætra Henrik Skaug , Fosch-Villaronga Eduard
Published: August 2021

Digital technologies have profound effects on all areas of modern life, including the workplace. Certain forms of digitalisation entail simply exchanging digital files for paper, while more complex instances involve machines performing a wide variety of tasks on behalf of humans. While some are wary of the displacement of humans that occurs when, for example, robots perform tasks previously performed by humans, others argue that robots only perform the tasks that robots should have carried out in the very first place and never by humans. Understanding the impacts of digitalisation in the workplace requires an understanding of the effects of digital technology on the tasks we perform, and these effects are often not foreseeable. In this article, the changing nature of work in the health care sector is used as a case to analyse such change and its implications on three levels: the societal (macro), organisational (meso), and individual level (micro). Analysing these transformations by using a layered approach is helpful for understanding the actual magnitude of the changes that are occurring and creates the foundation for an informed regulatory and societal response. We argue that, while artificial intelligence, big data, and robotics are revolutionary technologies, most of the changes we see involve technological substitution and not infrastructural change. Even though this undermines the assumption that these new technologies constitute a fourth industrial revolution, their effects on the micro and meso level still require both political awareness and proportional regulatory responses.
Agronomic Biofortification of Garlic through Selenium and Arbuscular Mycorrhizal Fungi Application
Authors: Yang Fan , Pan Yupeng , Ali Ahmad , Zhang Siyu , Li Xiaxia , Qi Xiaofang , Liu Hongjiu , Meng Huanwen , Cheng Zhihui
Published: August 2021

Garlic has a strong ability of selenium (Se) accumulation and is one of the best target crops for Se biofortification. Arbuscular mycorrhizal fungi (AMF) inoculation might enhance the nutritional qualities and the absorption ability of exogenous Se in plants. However, little is known about the exogenous Se application and AMF inoculation on garlic. Here, we evaluated the effects of different concentrations of exogenous Se on the growth, nutritional quality, and selenium enrichment of garlic. The results demonstrated that significantly higher Se content of garlic bulb was found in exogenous Se treated plants, and the Se accumulation was improved with the increasing of Se supply. Low application of exogenous Se appreciably improved the yield and the contents of soluble sugar and allicin in garlic bulbs, but the opposite was observed at high Se concentration. Furthermore, AMF inoculation significantly reduced the inhibition effect of high concentration Se on garlic. AMF supply was effective in improving the growth and nutritional indicators of garlic, which promoted the exogenous Se utilization rate when combined with 10 mg/L exogenous Se treatment. The results will provide a more theoretical basis for the production of high-quality selenium enrichment garlic.
Geophagic Clays from Cameroon: Provenance, Metal Contamination and Health Risk Assessment
Authors: Ekosse Georges-Ivo , Nkeng George Elambo , Bukalo Nenita , Oyebanjo Olaonipekun
Published: August 2021

This study assessed the mineralogical and geochemical characteristics of geophagic clays sold in some markets in Cameroon to ascertain their provenance, contamination status and human health risk. To achieve this, 40 samples from 13 markets in Cameroon were purchased and analysed using X-ray diffractometry, X-ray fluorescence and laser ablation inductively coupled plasma mass spectrometry for their mineralogy and geochemistry, respectively. The geophagic clays were dominantly made up of kaolinite and quartz. Their chemistry was dominated by SiO2, Al2O3 and LOI with means of 48.76 wt%, 32.12 wt% and 13.93 wt%, respectively. The major, trace and rare earth elements data showed that these geophagic clays were predominantly derived from felsic rocks. The contamination assessment indicated no enrichment of metals from anthropogenic sources, except for Zn in samples from Acacia, Madagascar and Mfoudi markets. The index of geo-accumulation indicated no contamination to moderate contamination of the clays. The non-carcinogenic index values for Fe, Co, Cr, Cu, Ni, Pb and Zn were generally less than 1, suggesting no non-carcinogenic risk exposure to children and adults consuming the geophagic clays from these metals. The carcinogenic risk index (TCR) for Ni and Cr were above 10−6, which implies that children and adults are vulnerable to minimal carcinogenic health risk. The TCR values from Ni posed the highest risk, especially to children consuming clays from some markets.
Eliciting Preferences of Providers in Primary Care Settings for Post Hospital Discharge Patient Follow-Up
Authors: Wang Xin , Song Kuimeng , Chen Lijin , Huang Yixiang , Birch Stephen
Published: August 2021

Background: Post-hospital discharge follow-up has been a principal intervention in addressing gaps in care pathways. However, evidence about the willingness of primary care providers to deliver post-discharge follow-up care is lacking. This study aims to assess primary care providers’ preferences for delivering post-discharge follow-up care for patients with chronic diseases. Methods: An online questionnaire survey of 623 primary care providers who work in a hospital group of southeast China. Face-to-face interviews with 16 of the participants. A discrete choice experiment was developed to elicit preferences of primary care providers for post-hospital discharge patient follow-up based on six attributes: team composition, workload, visit pattern, adherence of patients, incentive mechanism, and payment. A conditional logit model was used to estimate preferences, willingness-to-pay was modelled, a covariate-adjusted analysis was conducted to identify characteristics related to preferences, 16 interviews were conducted to explore reasons for participants’ choices. Results: 623 participants completed the discrete choice experiment (response rate 86.4%, aged 33 years on average, 69.5% female). Composition of the follow-up team and adherence of patients were the attributes of greatest relative importance with workload and incentives being less important. Participants were indifferent to follow-up provided by home visit or as an outpatient visit. Conclusion: Primary care providers placed the most importance on the multidisciplinary composition of the follow-up team. The preference heterogeneity observed among primary care providers suggests personalized management is important in the multidisciplinary teams, especially for those providers with relatively low educational attainment and less work experience. Future research and policies should work towards innovations to improve patients’ engagement in primary care settings.
Analysis on the Temporal and Spatial Features of the Coupling and Coordination of Industrialization and Agricultural Green Development in China during 1990–2019
Authors: Guo Hongpeng , Yi Xin , Pan Chulin , Yang Baiming , Li Yin
Published: August 2021

In the past 30 years, China’s industrialization level has developed rapidly, and agricultural green development (AGD) is facing severe challenges. The research on the temporal and spatial features of the coupling and coordination of industrialization and agricultural green development is a key issue to promote the sustainable development of agriculture. This paper takes China’s industrialization and AGD level as the research object, and uses panel data from 31 provinces in China from 1990 to 2019 to construct an evaluation index system for industrialization and AGD. This paper uses the coupling coordination degree model and spatial autocorrelation analysis method to calculate, test and analyze the temporal and spatial features of the coupling coordination level of industrialization and AGD. The results show that: this paper compares the industrialization and AGD levels during the study period and finds that China’s industrialization development level is on the rise as a whole, and the AGD level shows a downward trend first and then rises later. Through the horizontal comparison of different regions, this paper finds that there is a large regional imbalance in the level of industrialization and AGD. The coupling and coordination level of industrialization and AGD has always been primary. From the time point of view, coupling coordination degree shows a trend of first decline and then rise. From a spatial point of view, coupling coordination degree varies greatly among provinces, with the eastern, central and western regions decreasing successively. The level of coupling coordination has obvious positive autocorrelation in spatial distribution, and presents significant spatial agglomeration characteristics in space. The research results can provide a theoretical basis for regionally differentiated governance of the coordinated development of industrialization and AGD, and promote coordinated development.
An Assessment of Government Capacity Building to Restrict the Marketing of Unhealthy Food and Non-Alcoholic Beverage Products to Children in the Region of the Americas
Authors: Patiño Sofía Rincón-Gallardo , Da Silva Gomes Fabio , Constantinou Steven , Lemaire Robin , Hedrick Valisa E. , Serrano Elena L. , Kraak Vivica I.
Published: August 2021

The Pan American Health Organization (PAHO) Strategic Plan 2020–2025 committed to reduce children’s consumption of energy-dense nutrient-poor food and beverage products high in fat, sugar and salt (HFSS) and promote healthy eating patterns to reduce malnutrition in all forms. This paper describes the capacity-building needs in PAHO’s Member States to restrict the marketing of HFSS food and beverages to children. We asked Ministries of Health officials or national institutes/departmental representatives (n = 35) to complete a 28-item web-based survey (January to July 2020). Capacity-building needs were assessed using an adapted version of the World Health Organization’s government capacity-building framework with three modules: public health infrastructure, policies and information systems. Notable achievements for the PAHO’s Plan of Action were identified. State representatives reported strong infrastructure and information systems; however, policy improvements are needed to increase comprehensive national responses. These include using a constitutional health and human rights approach within the policies, policies that document conflict of interest from non-state actors, and strengthening regulatory oversight for digital media platforms. These findings provide baseline data and we suggest priorities for further action to strengthen national governments’ capacity-building and to accelerate the development, implementation, and monitoring systems to restrict the marketing of HFSS food and non-alcoholic beverages to children in the region of the Americas.
Analysis and Prediction of Vehicle Kilometers Traveled: A Case Study in Spain
Authors: Narváez-Villa Paúl , Arenas-Ramírez Blanca , Mira José , Aparicio-Izquierdo Francisco
Published: August 2021

Knowledge of the kilometers traveled by vehicles is essential in transport and road safety studies as an indicator of exposure and mobility. Its application in the determination of user risk indices in a disaggregated manner is of great interest to the scientific community and the authorities in charge of ensuring road safety on highways. This study used a sample of the data recorded during passenger vehicle inspections at Vehicle Technical Inspection stations and housed in a data warehouse managed by the General Directorate for Traffic of Spain. This study has three notable characteristics: (1) a novel data source is explored, (2) the methodology developed applies to other types of vehicles, with the level of disaggregation the data allows, and (3) pattern extraction and the estimate of mobility contribute to the continuous and necessary improvement of road safety indicators and are aligned with goal 3 (Good Health and Well-Being: Target 3.6) of The United Nations Sustainable Development Goals of the 2030 Agenda. An Operational Data Warehouse was created from the sample received, which helped in obtaining inference values for the kilometers traveled by Spanish fleet vehicles with a level of disaggregation that, to the knowledge of the authors, was unreachable with advanced statistical models. Three machine learning methods, CART, random forest, and gradient boosting, were optimized and compared based on the performance metrics of the models. The three methods identified the age, engine size, and tare weight of passenger vehicles as the factors with greatest influence on their travel patterns.
Age and Sex Specific Trends in Incidence of Juvenile Idiopathic Arthritis in Danish Birth Cohorts from 1992 to 2002: A Nationwide Register Linkage Study
Authors: Cardoso Isabel , Frederiksen Peder , Specht Ina Olmer , Händel Mina Nicole , Thorsteinsdottir Fanney , Heitmann Berit Lilienthal , Kristensen Lars Erik
Published: August 2021

This study reports age- and sex-specific incidence rates of juvenile idiopathic arthritis (JIA) in complete Danish birth cohorts from 1992 through 2002. Data were obtained from the Danish registries. All persons born in Denmark, from 1992–2002, were followed from birth and until either the date of first diagnosis recording, death, emigration, 16th birthday or administrative censoring (17 May 2017), whichever came first. The number of incident JIA cases and its incidence rate (per 100,000 person-years) were calculated within sex and age group for each of the birth cohorts. A multiplicative Poisson regression model was used to analyze the variation in the incidence rates by age and year of birth for boys and girls separately. The overall incidence of JIA was 24.1 (23.6–24.5) per 100,000 person-years. The rate per 100,000 person-years was higher among girls (29.9 (29.2–30.7)) than among boys (18.5 (18.0–19.1)). There were no evident peaks for any age group at diagnosis for boys but for girls two small peaks appeared at ages 0–5 years and 12–15 years. This study showed that the incidence rates of JIA in Denmark were higher for girls than for boys and remained stable over the observed period for both sexes.
Examination of Construct Validity and Criterion-Related Validity of the German Motor Test in Egyptian Schoolchildren
Authors: Abdelkarim Osama , Fritsch Julian , Jekauc Darko , Bös Klaus
Published: August 2021

Physical fitness is an indicator for children’s public health status. Therefore, the aim of this study was to examine the construct validity and the criterion-related validity of the German motor test (GMT) in Egyptian schoolchildren. A cross-sectional study was conducted with a total of 931 children aged 6 to 11 years (age: 9.1 ± 1.7 years) with 484 (52%) males and 447 (48%) females in grades one to five in Assiut city. The children’s physical fitness data were collected using GMT. GMT is designed to measure five health-related physical fitness components including speed, strength, coordination, endurance, and flexibility of children aged 6 to 18 years. The anthropometric data were collected based on three indicators: body height, body weight, and BMI. A confirmatory factor analysis was conducted with IBM SPSS AMOS 26.0 using full-information maximum likelihood. The results indicated an adequate fit (χ2 = 112.3, df = 20; p < 0.01; CFI = 0.956; RMSEA = 0.07). The χ2-statistic showed significant results, and the values for CFI and RMSEA showed a good fit. All loadings of the manifest variables on the first-order latent factors as well as loadings of the first-order latent factors on the second-order superordinate factor were significant. The results also showed strong construct validity in the components of conditioning abilities and moderate construct validity in the components of coordinative abilities. GMT proved to be a valid method and could be widely used on large-scale studies for health-related fitness monitoring in the Egyptian population.
Selenium Status, Its Interaction with Selected Essential and Toxic Elements, and a Possible Sex-Dependent Response In Utero, in a South African Birth Cohort
Authors: Röllin Halina B. , Channa Kalavati , Olutola Bukola , Odland Jon Øyvind
Published: August 2021

Selenium (Se) is an essential trace element and its deficiency in utero may affect fetus development and birth outcomes. The current study aimed to assess serum Se status at delivery and examine the possible association between Se levels and birth outcomes. The interaction of Se with selected essential and toxic elements as well as possible sex-dependent responses in utero were also evaluated. The negative association between Se levels and head circumference of neonates was evident in the total cohort (β = −0.164; p < 0.001) as well as in the pre-term and full-term cohorts. Significant positive correlations were found between maternal serum Se concentrations and zinc (Zn) and copper (Cu) in the total and regional cohorts. In the total cohort, the toxic elements lead (Pb) and arsenic (As) showed a negative correlation with Se levels, while mercury (Hg), aluminum (Al) and cadmium (Cd) showed a positive correlation. The study found a sex-dependent response in utero for Zn, Cu, Pb, Hg, and Al. The findings of the current study may inform reproductive health policy on Se status in South Africa and highlight the need for sensitive methods to measure Se intake during pregnancy and its complex interactions with other micronutrients and environmental pollutants.
Modeling Patterns in Map Use Contexts and Mobile Map Design Usability
Authors: Bartling Mona , Havas Clemens R. , Wegenkittl Stefan , Reichenbacher Tumasch , Resch Bernd
Published: August 2021

Mobile map applications are increasingly used in various aspects of our lives, leading to an increase in different map use situations and, therefore, map use contexts. Several empirical usability studies have identified how map design is associated with and impacted by selected map use context attributes. This research seeks to expand on these studies and analyzes combinations of map use contexts to identify relevant contextual factors that influence mobile map design usability. In a study with 50 participants from Colombia, we assessed in an online survey the usability of 27 map design variations (consisting of three map-reading tasks, three base map styles, and three interactivity variants). We found that the overall map design is critical in supporting map-reading activities (e.g., identifying a location on a map was supported by a simplified base map, whereas selecting points on the map was supported by a more detailed base map). We then evaluated user patterns in the collected data with archetypal analysis. It was possible to create archetypal representations of the participants with a corresponding map design profile and establish a workflow for modeling patterns in usability and context data. We recommend that future research continues assessing archetypal analysis as it provides a means for context-based decision-making on map design adaptation and transferability.