bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of the influence of machining fixture layout on the workpiece’s dimensional accuracy using genetic algorithm
Authors: Abedini Vahid , Shakeri Mohsen , Siahmargouei Mohammad Hasan , Baseri Hamid
Published: March 2014

Fixture error is one of the error sources in machining operations. Locator position inaccuracy and locator height error are the main sources of fixture error. The optimal positions of the locators are a critical problem for minimizing the geometrical and dimensional error of workpiece. This article proposes a genetic algorithm–based optimization method to arrive at a layout of locators for minimum machining error in 3-2-1 locating approach. The focus of this optimization is the positional tolerance of holes. So, a mathematical model of the hole position tolerance with respect to variation of locator position is developed. The planes of the workpiece actual coordinate system are mathematically modeled on the workpiece theoretical coordinate system. The capability of the proposed approach has been shown by using an example. The result shows that the proposed genetic algorithm method can be used to calculate locating errors and find the optimal locating layout within the specified tolerance range, which is critical for fixture design in hole-making process.
Experimental study of the effect of water injection on the cycle performance of an internal-combustion Rankine cycle engine
Authors: Wu Zhi-jun , Yu Xiao , Fu Le-zhong , Deng Jun , Li Li-guang
Published: March 2014

The internal-combustion Rankine cycle engine uses pure oxygen instead of air as the oxidant during the combustion process so as to preclude the creation of nitrogen oxide emissions. Carbon dioxide can be recovered from the water vapour–carbon dioxide exhaust gas mixture through condensation at a relatively low cost and, thus, an ultra-low-emission working cycle is achieved. In this paper the working process of the internal-combustion Rankine cycle was studied on the basis of bench tests on a prototype engine. An oxygen–carbon dioxide mixture was utilized to simulate exhaust gas recirculation in order to control the combustion process, and water was injected near top dead centre to determine the impact on the reaction rate and the cycle performance. The results demonstrated that water injected at a temperature of 120 °C can modulate the reaction rate and expand the area of the pressure–volume diagram through vaporization. Furthermore, combustion phasing is retarded without reducing the maximum cylinder pressure. The indicated work under the test conditions is increased by 7.8%. However, when the water-injection temperature is 20 °C, the cycle performance is reduced.
Fuzzy grey relational analysis of design factors influencing on maintainability indices
Authors: Luo Xu , Yang Yongmin , Ge Zhexue , Wen Xisen , Guan Fengjiao
Published: March 2014

Maintainability is a design attribute of a product, and its relationship with the design factors is complicated. In consideration of the fuzziness and uncertainty of design factors that influences the product's maintainability indices, we propose a method based on fuzzy grey relational analysis to determine their prioritization in this paper. First, the evaluation methods of various design factors and how these factors affect product maintainability indices are analyzed. Then, the fuzzy grey relational analysis model of the relationship between the design factors and maintainability indices is set up, and the prioritization of design factors to maintainability indices is achieved. Finally, the proposed methods are applied on a subsystem of a manned spacecraft, which indicates that the proposed method can quantitatively analyze the influencing degree of the design factors to maintainability indices. This information can be used to guide maintainability indices evaluation modeling based on digital mock-up in the design phase and help to catch the major influencing design factors in maintainability design.
Experimental measurements of hot gas ingestion through turbine rim seals at off-design conditions
Authors: Scobie James A , Sangan Carl M , Owen J Michael , Wilson Michael , Lock Gary D
Published: March 2014

This paper describes results obtained from an experimental facility, which models ingress through the rim seal into the upstream wheel-space of an axial-turbine stage. The experimental rig included 32 nozzle guide vanes and 41 symmetrical turbine blades, and the paper presents measurements of ɛ (the sealing effectiveness) for single- and double-clearance seals for both over-speed (where the blades rotate faster than at the design point) and under-speed conditions. The design flow coefficient was CF = 0.538, and tests were conducted for 0 <  CF < 0.9, which is larger than the range experienced in engines. The measured values of ɛ were correlated by the ‘effectiveness equations’ for rotationally-induced (RI) and externally-induced (EI) ingress. The correlated effectiveness curves were used to determine [Formula: see text] (the value of the sealing flow parameter when ɛ = 0.95), and the variation of [Formula: see text] with CF that was in mainly good agreement with the theoretical curve for combined ingress, which covered the transition from rotationally-induced to externally-induced ingress. Departure of the measured values of [Formula: see text] from the combined ingress curve occurred at very low values of CF for all the seals tested; this was attributed to the effects of separation of the mainstream flow over the turbine blades at large ‘deviation angles’ between the flow and the blades. The measurements are expected to be qualitatively similar to but quantitatively different from those experienced in engines.
Grading of shoulder ulcerations in sows by biopsies
Authors: Jensen Henrik E. , Dahl-Pedersen Kirstin , Barington Kristiane , Kaiser Marianne , Bonde Marianne K. , Herskin Mette S. , Jensen Karin H.
Published: March 2014

Shoulder ulcerations can be graded postmortem from 0 to 4 on a pathoanatomical scale. However, veterinarians and farmers express difficulties evaluating the grade of the lesions antemortem. Accurate grading is needed in order to comply with veterinary instruction in relation to the Danish legislation, stating that sows with shoulder ulcers grade 3 or 4 must be kept loose and have access to soft bedding. Thus, the aim of the present study was to evaluate if biopsies from the center of a shoulder ulcer can be used to point out animals for which an intervention must be initiated. Postmortem, a punch biopsy was sampled from the center of the ulceration or from the tissue overlaying the tuber spina scapula. Afterward, the shoulders were cross-sectioned and evaluated grossly and histologically (“gold standard”). In total, 121 shoulders were included in the study, and the diagnostic value of a punch biopsy in grading shoulder ulcerations was evaluated. The results showed a sensitivity of 0.78, a specificity of 0.98, a positive likelihood ratio of 38.36, and a negative likelihood ratio of 0.22. The agreement between the cross-section evaluation and the punch biopsy was found to be 0.90 by calculating the Cohen kappa value. In conclusion, a single punch biopsy from the center of an ulcer is useful for determining the grade of a shoulder ulcer and can be used to facilitate the identification of sows with ulcers requiring an intervention.
Applied self-powered semi-passive control for a 2-degree-of-freedom aeroelastic typical section using shunted piezoelectric materials
Authors: D’Assunção Douglas , De Marqui Junior Carlos
Published: March 2014

The use of smart materials in vibration control problems, including aeroelastic response, has been investigated in several researches over the last years. Although different smart materials are available, the piezoelectric one has received great attention due to ease of use as sensors, actuators, or both. The main control techniques using piezoelectric materials are the active and passive ones. In the case of aeroelastic control, passive piezoelectric networks have a weak capability of improving the flutter stability margin. Although active systems can achieve good vibration control performance, the amount of external power and added hardware are important issues for active aeroelastic control. In this article, the self-powered semi-passive piezoelectric control of a wind tunnel model aeroelastic response is presented as an alternative to active and passive systems. Linear and nonlinear aeroelastic cases are examined using a test apparatus that allows for experiments of pitch and plunge degrees of freedom of a typical section. Piezoelectric coupling is introduced onto the plunge degree of freedom, and two different semi-passive control schemes are employed: the synchronized switch damping on short circuit and the synchronized switch damping on inductor. An autonomous and self-powered switching circuit is employed, providing a useful self-powered method of aeroelastic control.
Power evaluation of flutter-based electromagnetic energy harvesters using computational fluid dynamics simulations
Authors: Park Jinkyoo , Morgenthal Guido , Kim Kyoungmin , Kwon Soon-Duck , Law Kincho H
Published: March 2014

H- and T-shaped cross sections are known to be susceptible to rotational single-degree-of-freedom aerodynamic instabilities. Here, such self-excited aerodynamic response of a T-shaped cantilever structure is used to extract energy, which is then converted into electric power through an electromagnetic transducer. The complex fluid–structure interaction between the cantilever harvester and wind flow is analyzed numerically and experimentally. To study the dynamic response of the cantilever and estimate the power output from the harvester, numerical simulations based on the vortex particle method are performed to determine the aerodynamic damping of the harvester section and to analyze the stability behavior of the section. The estimated aerodynamic damping parameter together with the mechanical and electrical damping parameters in the harvester are used to find the critical wind speed of flutter onset as well as the optimum load resistance. Wind tunnel experiments are conducted to validate the simulation results.
Single and multiple healing of porous and dense asphalt concrete
Authors: García Alvaro , Norambuena-Contreras Jose , Bueno Moises , Partl Manfred N
Published: March 2014

When the temperature of asphalt concrete is above a certain threshold, bitumen may start flowing through any possible crack and healing it. Induction heating is a technique for increasing the temperature of asphalt mixture. It consists of adding electrically conductive and magnetically susceptible particles to the mixture. These particles can be heated thanks to the action of an induction heating apparatus. The objective of this article is to investigate the effect of different asphalt mixture porosities and different types of bitumen on the induction-healing rates of asphalt concrete. With this purpose, semi-circular test samples made of porous asphalt mixture, with bitumen pen 70/100, and dense asphalt mixture, with bitumen pen 40/50, both of them containing steel wool fibres, have been analysed through successive three-point bending and induction heating tests. It has been found that the minimum temperature above which healing of asphalt mixture starts depends on the capacity for flow of bitumen at the threshold temperature. Moreover, the maximum healing level reached by asphalt mixture after damage is related to the type of bitumen used. Finally, it has also been found that successive heating of asphalt mixture may damage the structure of the material, reducing its healing capacity.
Accepting Transitions
Authors: Yancu Cecile N. , Farmer Deborah F. , Graves Mara J. , Rhinehardt April , Leahman Dee
Published: March 2014

Background:

African Americans typically underuse hospice care; this study explores their end of life attitudes.

Methods:

An iterative focus group strategy generated qualitative data using 4 baseline groups and 1 confirmatory focus group recruited from predominantly African American churches. Each group consisted of 8 to 14 adults. Investigators analyzed data for dominant themes, representatives from baseline groups returned to discuss the results.

Results:

A total of 43 African Americans (male: 8 [18.6]; female: 35 [81.4]) participated in initial discussions, with 10 returning for follow-up. The prevailing theme was transitions; with life to death dominating discourse; other themes included curative to palliative care and acceptance of death as inevitable.

Recommendation:

Among African Americans, outreach efforts may be strengthened by reframing the dying process as the product of many transitions and reaching out to faith-based communities.
Parental Roles in the Education of Mathematically Gifted and Talented Children
Authors: Bicknell Brenda
Published: March 2014

Parent recognition of mathematical giftedness and involvement in their children’s mathematics education is the focus of this case study. Data were collected from the parents of 15 children (aged 10-13 years) identified by their schools in New Zealand as mathematically gifted and talented. Many of the parents identified their child’s propensity for mathematics at an early age. Results also indicated that parents played key roles as motivators, resource providers, monitors, mathematics content advisers, and mathematical learning advisers. On occasion, parents assumed an advocacy role. The partnership between parents and schools was not strong, but it is clear from this study that this partnership could be strengthened.
Historical Perspectives
Authors: Jolly Jennifer L.
Published: March 2014

From February 6 to 8, 1958, approximately 200 educators and interested individuals were invited to New York City in hopes of discussing the education of academically talented students at the secondary level. Topics included identification, programming options, the social emotional well-being of students, and the limited resources allocated to talented students. The author concludes that the issues addressed are eerily similar to gifted education today.
Advocacy
Authors: Kaplan Sandra N.
Published: March 2014

The author describes key issues and uncommon concerns about the Common Core State Standards that fit within two categories: philosophical and pedagogical. Philosophically, Common Core State K-12 Standards should not be expected to be mastered at a specific grade level but based on developmental readiness. Pedagogically, Common Core State Standards need to be taught using inquiry or discovery, and independent study strategies, rather than direct instructional strategies.
Achieving Equity and Excellence
Authors: Harris Bryn , Plucker Jonathan
Published: March 2014

The United States is becoming more racially, ethnically, and linguistically diverse, yet the educational attainment of various student groups has been very uneven. For decades, educators and policymakers have been focused on minimal competencies rather than advanced achievement. Specifically, federal and state education policies have focused on closing achievement gaps at basic levels of achievement, which has allowed excellence gaps to grow considerably. This article describes ways in which school mental health professionals can address excellence gaps and serve as advocates for all high-ability students.
Metasynthesis of Research on the Role of Psychiatric Inpatient Nurses
Authors: Delaney Kathleen R. , Johnson Mary E.
Published: March 2014

BACKGROUND: Inpatient psychiatric nurses are a large workforce, but their work is poorly articulated and thus poorly understood outside of the professional inpatient community. OBJECTIVE: To learn how inpatient psychiatric nurses depict their work, define important aspects of their role, and view the impact of the unit environment on their clinical practice. DESIGN: Metasynthesis of research that has focused on the ideas and perceptions of inpatient psychiatric nurses around their role and practice on inpatient psychiatric units. RESULTS: Three themes emerged from the analysis; the first was an umbrella for three important aspects of nursing work: the nurses’ efforts to forge engagement with patients; their activities which maintained the safety of the unit and interventions nurses viewed as educating/empowering patients. The second theme captures the conditions that enabled nurses to do this work such as a cohesive nursing team and their sense of self-direction in their role. The final theme centers on difficulties nurses encountered in enacting their role which included multiple responsibilities for patient care and management of the milieu; intense work often with low visibility and scant support within the organization. CONCLUSIONS: Nurses need to articulate their practice so they can assert for the staffing and resources needed to keep units safe and promote patients’ well-being, strive toward quality, and promote the development of the specialty.
File sharing beyond grabbing and running
Authors: Holmström Jonny
Published: March 2014

This study examines how a file sharing system affects its users’ sense of community (SOC). It was expected that the file sharing system would increase members’ knowledge about and participation in the file sharing network which, in turn, would increase their SOC. The aim of this study was to identify the barriers that hinder community building in file sharing networks, by examining how use of a specific network – Direct Connect++ (DC++) – affects its users’ SOC. It was our hypothesis and expectation that extended use of file sharing system would increase members’ knowledge about, and participation in, the file sharing network, and this in turn would increase their SOC. However, although DC++ was found to have a number of properties that coincide with the theories of SOC, two barriers were found that hindered DC++ from working as a genuine community. These barriers were related to anonymity and elitism among community members. The findings challenge previous idealistic theories about the development of an SOC but nonetheless demonstrate the positive effects of network membership.
Research ethics in global mental health: Advancing culturally responsive mental health research
Authors: Ruiz-Casares Mónica
Published: March 2014

Global mental health research is needed to inform effective and efficient services and policy interventions within and between countries. Ethical reflection should accompany all GMHR and human resource capacity endeavors to ensure high standards of respect for participants and communities and to raise public debate leading to changes in policies and regulations. The views and circumstances of ethno-cultural and disadvantaged communities in the Majority and Minority world need to be considered to enhance scientific merit, public awareness, and social justice. The same applies to people with vulnerabilities yet who are simultaneously capable, such as children and youth. The ethical principles of respect for persons or autonomy, beneficence/non-maleficence, justice, and relationality require careful contextualization for research involving human beings. Building on the work of Fisher and colleagues (2002), this article highlights some strategies to stimulate the ethical conduct of global mental health research and to guide decision-making for culturally responsible research, such as developing culturally sensitive informed consent and disclosure policies and procedures; paying special attention to socioeconomic, cultural, and environmental risks and benefits; and ensuring meaningful community and individual participation. Research and capacity-building partnerships, political will, and access to resources are needed to stimulate global mental health research and consolidate ethical practice.
Bioclimatic chart analysis in three climate zones in Cyprus
Authors: Katafygiotou M. C. , Serghides D. K.
Published: March 2014

The concept of bioclimatic design is based on the development of an architectural design adapted to environmental conditions. The utilization of the favourable climatic elements can offer to the users, indoor thermal comfort conditions and at the same time it minimizes the energy consumption which is needed for heating and cooling. This paper provides the bioclimatic analysis for three different climatic zones in Cyprus, coastal, inland and mountainous. The building bioclimatic charts of V. & A. Olgyay are used to examine whether passive strategies can provide indoor thermal comfort in the buildings in these zones. The results of bioclimatic charts are studied in conjunction with the climatic data for the three climatic areas. These are compared and investigated in order to find whether there is sufficient amount of solar radiation for passive heating needed to achieve thermal comfort during winter. The study concludes to a preliminary guide of passive design strategies for buildings, as an outcome of the bioclimatic charts analysis for coastal, inland and mountainous zones in Cyprus. The results can be used for locations with similar climatic conditions.
Characterization of 222Rn and meteorological parameters in Uro houses at South Kordofan state
Authors: Idriss Hajo , Salih Isam , Alaamer Abdulaziz S. , Abdelgali M.Y. , Salih Salih Ali , Hasan Amna M. , ELtahir Mohammed A. , Ahamed Mustafa M.O.
Published: March 2014

This study was carried out to assess and map indoor radon concentration and to estimate radiation dose in Uro town in Sudan's South Kordofan state. A portable radon meter (RRA-01M-03), equipped with simple sensors of meteorological parameters has been used for carrying out radon measurement. The annual absorbed dose from the corresponding measured radon concentration was calculated using dose rate conversion factors of the United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR). The corresponding annual effective dose and equivalent dose to the lungs were estimated. Measured activity concentrations of 222Rn, annual absorbed dose, annual effective dose and equivalent dose to the lungs were found in the range 20–4482 Bq/m3, 0.32–70.67 mSv/y, 0.76–169.61 mSv−y and 0.16 × 10−7 to 35,856 × 3.5856 × 10−11 mSv−y, with geometric mean 109.43 Bq/m3, 1.73, 4.16 and 1.1 × 10−7 mSv−y, respectively. Upon comparing the results with global data, it was found with the exception of six samples, the obtained values fall far below the action level of 200–600 Bq/m3 recommended by the International Commission on Radiological Protection. However, the geometric mean is higher than the reported average global indoor radon concentration. Meteorological parameters were measured and no correlation was noted between radon concentration and these parameters. The overall annual effective dose was higher than the UNSCEAR recommended reference dose level of 1.0 mSv−y.
Media and conflict: An assessment of the evidence
Authors: Schoemaker Emrys , Stremlau Nicole
Published: March 2014

This article assesses the evidence used in arguments for the role of the media in conflict and post-conflict situations. It focuses on two broad areas within the literature. First, it examines literature on the contribution of media in war to peace transitions, including an assessment of the evidence used to show how the media may contribute to violent conflict and how they may provoke, or hinder, post-conflict reconstruction. Second, it assesses evidence used in arguments for the role new Information and Communication Technologies (ICTs) such as the Internet and mobile phones may have in liberation or oppression in developing country contexts. Through reviewing some of the most significant papers that were systematically selected in a literature review on media and conflict, our findings suggest that there are serious gaps in the evidence and the majority of evidence is located in the ‘grey literature’ or policy documents. The article concludes by suggesting future research agendas to address these gaps.
Exports, imports, government consumption and economic growth in upper-middle income countries
Authors: Dao Minh Quang
Published: March 2014

Esfahani ( 1991 ) shows that the statistically significant correlation between export promotion and economic growth in semi-industrialized countries (SICs) has been mainly attributable to the role of exports in reducing import ‘shortages’, which have impeded output growth in these countries. As a result, export-promotion policies as a superior development strategy in SICs play an important role in those that cannot secure sufficient foreign aid or investment. Esfahani ( 1991 ) also develops a simultaneous equations model to address the simultaneity bias between GDP and export growth rates. In this article we extend the model developed by Esfahani ( 1991 ) by incorporating the contribution of government consumption to output growth and test it using a sample of 27 upper-middle income economies.
Book review: Bulkeley, Harriet and Newell, Peter. 2010: Governing Climate Change (Global Institutions)
Authors: Alfranca Oscar
Published: March 2014

Bulkeley, Harriet and Newell, Peter. 2010: Governing Climate Change (Global Institutions). Abingdon and New York: Routledge. 142 pp. £18.99 paperback and e-book, £85.00 hardback. ISBN: 978-0-415-46768-1 hardback. ISBN: 978-415-46769-8 (paperback), ISBN: 978-0-203-85829-5 (e-book).
Drive for Show and Putt for Dough? Not Anymore
Authors: Baugher Carson D. , Day Jonathan P. , Burford Elvin W.
Published: March 2014

Ten years ago, some golf analysts believed that “drive for show and putt for dough” may no longer be true on the Professional Golfers’ Association Tour. Scholars analyzed data from 1991 to 2002 and found that the old adage was still true since putting remained the number one skill determining earnings. We updated their models with data from 2006 to 2013 and found that driving replaced putting as the number one skill determining earnings starting in 2011. The most likely reasons for this return to skill are the lengthening of the courses and the shortening of the rough.
Protein S-nitrosylation in preconditioning and postconditioning
Authors: Penna Claudia , Angotti Carmelina , Pagliaro Pasquale
Published: March 2014

The coronary artery disease is a leading cause of death and morbidity worldwide. This disease has a complex pathophysiology that includes multiple mechanisms. Among these is the oxidative/nitrosative stress. Paradoxically, oxidative/nitrosative signaling plays a major role in cardioprotection against ischemia/reperfusion injury. In this context, the gas transmitter nitric oxide may act through several mechanisms, such as guanylyl cyclase activation and via S-nitrosylation of proteins. The latter is a covalent modification of a protein cysteine thiol by a nitric oxide-group that generates an S-nitrosothiol. Here, we report data showing that nitric oxide and S-nitrosylation of proteins play a pivotal role not only in preconditioning but also in postconditioning cardioprotection.
Characterization of inflammatory response induced by Potamotrygon motoro stingray venom in mice
Authors: Kimura Louise F , Prezotto-Neto José P , Antoniazzi Marta M , Jared Simone GS , Santoro Marcelo L , Barbaro Katia C
Published: March 2014

Freshwater stingray accidents cause intense pain followed by edema, erythema, and necrosis formation. Treatment for stingray envenomation is based on administration of analgesic, antipyretic, and anti-inflammatory drugs. This report evaluated the local inflammatory reaction—including edema formation, leukocyte recruitment, release of inflammatory mediators, and histopathological changes—after the intraplantar injection of Potamotrygon motoro stingray venom in mice. Edema was observed as soon as 15 min after venom injection, peaking at 30 min, and lasted up to 48 h. In addition, P. motoro venom increased neutrophil counts in the site of injection, at all time periods and venom doses analyzed. Increased eosinophil and lymphocyte counts were detected mainly at 24 h. Moreover, monocytes/macrophages were observed in large amounts at 24 and 48 h. Microscopically, the venom induced leukocyte migration to the injured tissue, edema, mast cell degranulation, angiogenesis, and epidermal damage. Inflammatory mediator release (IL-6, MCP-1 and KC) was detected as soon as 1 h after venom injection, and it increased significantly at 4 h. At 24 h, the venom induced only the production of MCP-1. These results show that this stingray venom evokes a complex inflammatory reaction, with rapid and persistent edema formation, leukocyte recruitment, and release of cytokines and chemokines.
Molecular diagnosis in clinical parasitology: When and why?
Authors: Wong Samson SY , Fung Kitty SC , Chau Sandy , Poon Rosana WS , Wong Sally CY , Yuen Kwok-Yung
Published: March 2014

Microscopic detection and morphological identification of parasites from clinical specimens are the gold standards for the laboratory diagnosis of parasitic infections. The limitations of such diagnostic assays include insufficient sensitivity and operator dependence. Immunoassays for parasitic antigens are not available for most parasitic infections and have not significantly improved the sensitivity of laboratory detection. Advances in molecular detection by nucleic acid amplification may improve the detection in asymptomatic infections with low parasitic burden. Rapidly accumulating genomic data on parasites allow the design of polymerase chain reaction (PCR) primers directed towards multi-copy gene targets, such as the ribosomal and mitochondrial genes, which further improve the sensitivity. Parasitic cell or its free circulating parasitic DNA can be shed from parasites into blood and excreta which may allow its detection without the whole parasite being present within the portion of clinical sample used for DNA extraction. Multiplex nucleic acid amplification technology allows the simultaneous detection of many parasitic species within a single clinical specimen. In addition to improved sensitivity, nucleic acid amplification with sequencing can help to differentiate different parasitic species at different stages with similar morphology, detect and speciate parasites from fixed histopathological sections and identify anti-parasitic drug resistance. The use of consensus primer and PCR sequencing may even help to identify novel parasitic species. The key limitation of molecular detection is the technological expertise and expense which are usually lacking in the field setting at highly endemic areas. However, such tests can be useful for screening important parasitic infections in asymptomatic patients, donors or recipients coming from endemic areas in the settings of transfusion service or tertiary institutions with transplantation service. Such tests can also be used for monitoring these recipients or highly immunosuppressed patients, so that early preemptive treatment can be given for reactivated parasitic infections while the parasitic burden is still low.
Vitamin D, immune regulation, the microbiota, and inflammatory bowel disease
Authors: Cantorna Margherita T , McDaniel Kaitlin , Bora Stephanie , Chen Jing , James Jamaal
Published: March 2014

The inflammatory bowel diseases are complex diseases caused by environmental, immunological, and genetic factors. Vitamin D status is low in patients with inflammatory bowel diseases, and experimental inflammatory bowel diseases are more severe in vitamin D-deficient or vitamin D receptor knockout animals. Vitamin D is beneficial in inflammatory bowel diseases because it regulates multiple checkpoints and processes essential for homeostasis in the gut. Vitamin D inhibits IFN-γ and IL-17 production while inducing regulatory T cells. In addition, vitamin D regulates epithelial cell integrity, innate immune responses, and the composition of the gut microbiota. Overall, vitamin D regulates multiple pathways that maintain gastrointestinal homeostasis. The data support improving vitamin D status in patients with inflammatory bowel diseases.
Intermittent hypoxia stimulates formation of binuclear neurons in brain cortex—A role of cell fusion in neuroprotection?
Authors: Paltsyn Alexander A , Manukhina Eugenia B , Goryacheva Anna V , Downey H Fred , Dubrovin Ivan P , Komissarova Svetlana V , Kubatiev Aslan A
Published: March 2014

Oligodendrocyte fusion with neurons in the brain cortex is a part of normal ontogenesis and is a possible means of neuroregeneration. Following such fusion, the oligodendrocyte nucleus undergoes neuron-specific reprogramming, resulting in the formation of binuclear neurons, which doubles the functional capability of the neuron. In this study, we tested the hypothesis that the formation of binuclear neurons is involved in long-term adaptation of the brain to intermittent hypobaric hypoxia, which is known to be neuroprotective. Rats were adapted to hypoxia in an altitude chamber at a simulated altitude of 4000 m above sea level for 14 days (30 min increasing to 4 h, daily). One micrometer sections of the left motor cortex were analyzed by light microscopy. Phases of the fusion and reprogramming process were recorded, and the number of binuclear neurons was counted for all section areas containing pyramidal neurons of layers III–V. For the control group subjected to sham hypoxia, the density of binuclear neurons was 4.49 ± 0.32 mm2. In the hypoxia-adapted group, this density increased to 5.71 ± 0.39 mm2 ( P < 0.04). In a subgroup of rats exposed to only one hypoxia session, the number of binuclear neurons did not differ from the number observed in the control group. We suggest that the increased content of binuclear neurons may serve as a structural basis for the neuroprotective effects of the adaptation to hypoxia.
Optimizing anesthetic regimen for surgery in mice through minimization of hemodynamic, metabolic, and inflammatory perturbations
Authors: Zuurbier Coert J , Koeman Anneke , Houten Sander M , Hollmann Markus W , Florijn Wouter J
Published: March 2014

The role of anesthetics in animal research models is crucial, yet often ignored, and is almost never the primary focus of examination. Here, we investigated the impact of anesthetic regimens on different parameters of hemodynamics (blood pressure (BP) and heart rate (HR)), metabolism (glucose, insulin, and free fatty acids (FFA)), and inflammation (IL-6 and TNF-α) in two frequently used mouse strains (C57BL/6 and FVB). All animals were at a similar surgical plane of anesthesia, mechanically ventilated, and monitored for 60 min. The following anesthetic regimens were studied: (1) fentanyl–ketamine–midazolam (FKM), (2) fentanyl–midazolam–haldol (FMH), (3) pentobarbital (P), (4) fentanyl–fluanisone–midazolam (FFM), (5) fentanyl–midazolam–acepromazine (FMA), (6) ketamine–medetomidine–atropine (KMA), (7) isoflurane (ISO), and (8) propofol–fentanyl–midazolam (PFM). Metabolic and inflammatory parameters were compared with those obtained from non-anesthetized animals. Hemodynamics: BP >80 mm Hg were only obtained with KMA, whereas hypotension (BP <60 mm Hg) was observed with FKM and P. HR >500 beats/min was observed with ISO and PFM, whereas HR <400 beats/min was induced with KMA, FMH (BL/6), P (BL/6), and FKM (FVB). Metabolism: Glucose and insulin were most disturbed by KMA and ISO and mildly disturbed by FMA, whereas FFM, PFM, and P did not have any effect. FFA increased largely by FMA, with ISO and FKM having no effects. Inflammation: Cytokines were increased least with ISO/FFM/FMA, whereas FKM and KMA induced the largest increases in cytokines. When aiming at achieving surgical anesthesia without large disturbances in hemodynamic, metabolic, and inflammatory profiles, FFM, ISO, or PFM may be the most neutral anesthetic regimens in mice.
Operation of Lumbar Zygoapophyseal Joint Cysts Using a Full-Endoscopic Interlaminar and Transforaminal Approach
Authors: Komp Martin , Hahn Patrick , Ozdemir Semih , Merk Harry , Kasch Richard , Godolias Georgios , Ruetten Sebastian
Published: March 2014

In appropriate situations, extensive decompression with laminectomy often continues to be described as the method of choice for operations involving lumbar zygoapophyseal joint (z-joint) cysts. Tissue-sparing procedures are nevertheless becoming more common. Endoscopic techniques have become the standard procedures in many areas because of the advantages they offer in terms of surgical technique and in rehabilitation. One key aspect in spinal surgery was the development of instruments for sufficient bone resection carried out under continuous visual control. This enabled endoscopes to be used when operating on z-joint cysts. The objective of this prospective study was to examine the technical possibilities for the full-endoscopic interlaminar and transforaminal technique in lumbar z-joint cysts. A total of 74 patients were followed up for 2 years. The results show that 85% of the patients no longer have any leg pain or that the pain had been almost completely eliminated, and 11 % experience occasional pain. The complication rate was low. The full-endoscopic techniques brought advantages in the following areas: operation, complications, traumatization, and rehabilitation. The recorded results show that full-endoscopic resection of a z-joint cyst using an interlaminar and transforaminal approach provides an adequate and safe supplement, and is an alternative to conventional procedures when the indication criteria are fulfilled. It also offers the advantages of a minimally invasive intervention.
Comparative Outcomes of Trocar Puncture With Sump Drain, Percutaneous Drainage, and Surgical Drainage in the Management of Intra-abdominal Abscesses in Crohn’s Disease
Authors: Liu Song , Ren Jianan , Gu Guosheng , Wang Gefei , Han Gang , Yan Dongsheng , Ren Huajian , Wu Xiuwen , Xia Qiuyuan , Zhou Bo , Chen Jun , Zhao Yunzhao , Li Jieshou
Published: March 2014

Background. Intra-abdominal abscess is a common complication in Crohn’s disease (CD). Traditional percutaneous catheter drainage (PCD) and surgical intervention could not obtain satisfactory results in some cases. We herein demonstrate a novel management option and compare it with traditional strategies. Methods. A total of 77 patients were retrospectively collected into 3 groups. Postoperative complication, postoperative recurrence of abscess, subsequent surgery, ultimate stoma creation rate, and survival rate were analyzed. Results. Patients were divided into the trocar group (n = 21), PCD group (n = 25), and surgery group (n = 31). The incidences of postoperative complication as well as the incidence of recurrent abscess were lowest in trocar group, and ultimate stoma creation rate was highest in the surgery group. Subsequent surgery after initial intervention and survival rate during the follow-up period were similar among the 3 groups. Conclusions. Trocar puncture with sump drain had lower incidence of postoperative complication, postoperative recurrence of abscess, and ultimate stoma creation compared with conventional PCD and surgical interventions. This novel technique might be an optimal option in the management of intra-abdominal abscesses in CD.
The use of high-flow nasal oxygen therapy in the management of hypercarbic respiratory failure
Authors: Millar Jonathan , Lutton Stuart , O’Connor Philip
Published: March 2014

Hypercarbic respiratory failure, occurring secondary to chronic lung disease, is a frequently encountered problem. These patients present a significant challenge to respiratory and critical care services, as many are unsuitable for mechanical ventilation and most have multiple comorbidities. Recently, noninvasive ventilation (NIV) has become established as the primary modality for respiratory support in this group of patients. Several factors limit patient compliance with NIV, not least comfort and tolerability. A recent innovation in adult critical care is the use of high-flow nasal oxygen (HFNO) devices. These systems are capable of delivering high gas flows via nasal cannulae, with the ability to blend air and oxygen to give a controlled FiO2. Few clinical studies have been conducted in adults, although several are planned. To date the majority of available evidence addresses the use of HFNO in hypoxemic respiratory failure. Here we present a case in which a HFNO system was used to successfully manage hypercarbic respiratory failure in a patient unable to tolerate conventional NIV.
Effect of the structural components of support on the loss of mechanical properties of football fields of artificial turf
Authors: Sánchez-Sánchez Javier , Felipe José L , Burillo Pablo , del Corral Julio , Gallardo Leonor
Published: March 2014

Football fields of artificial turf are in constant evolution. The resulting improvements have given rise to a large diversity of structural components. There are various types of infill and fibre for artificial turf and different designs and materials for the support structure (sub-base and elastic layer). The design of the sub-base and the presence or absence of the elastic layer can influence turf performance and the surface’s useful lifetime. The aim of this study was to assess in situ the effect of the various support structures on the mechanical properties of artificial turf after deterioration caused by wear for a year. The assessed properties were force reduction (%), standard vertical deformation (mm), rotational traction (N·m), vertical ball rebound (%), and ball roll (m), according to the requirements in norm EN 15330-1:2007. The results demonstrate the effect of the structural base on the mechanical and functional performance of football fields of artificial turf, as well as the significant deterioration of the properties over a year which varied between 3.14% and 8.92% with regard to the installed system. These results show that the support structure that provides the greatest durability and adequate behaviour of the mechanical properties over time is that which has a sub-base of compacted gravel under an elastic layer.
The difficult intraoperative nasogastric tube intubation: A review of the literature and a novel approach
Authors: Ching Yiu-Hei , Socias Stephanie M , Ciesla David J , Karlnoski Rachel A , Camporesi Enrico M , Mangar Devanand
Published: March 2014

Nasogastric tube intubation of a patient under general anesthesia with an endotracheal tube in place can pose a challenge to the most experienced anesthesiologist. Physiologic and pathologic variations in a patient’s functional anatomy can present further difficulty. While numerous techniques to the difficult nasogastric tube intubation have been described, there is no consensus for a standard approach. Therefore, selecting the most appropriate approach requires a working knowledge of the techniques available, mindful consideration of individual patient and clinical factors, and the operator’s experience and preference. This article reviews the relevant literature regarding various approaches to the difficult nasogastric tube intubation with descriptions of techniques and results from comparative studies if available. Additionally, we present a novel approach using a retrograde technique for the difficult intraoperative nasogastric tube intubation.
On the Meaning of כלח in Job 5.26 and 30.2
Authors: Pinker Aron
Published: March 2014

This article suggests that כלח is a compound word; the contraction of כֺּל + לֵחַ, “all vigor.” This meaning aptly applies to both occurrences of כלח, if in 30.2b one reads חֵילָמוֹ instead of עָלֵימוֹ.
Whatever Must Be, Must Be: Translating the Imperative in Luke 7.7
Authors: Miller Robert P.
Published: March 2014

This article is an analysis of the imperative iathētō in Luke 7.7. It looks at the textual problems regarding the imperative and argues that the future iathēsetai is an attempt at harmonization with Matthew’s version. After making arguments regarding God’s commands and the theme of authority in the text, the author concludes that those translations which render iathētō in the future or permissive senses do not do justice to the force of the imperative. The author suggests the translation, “but say a word and my servant must be healed,” similar to the NET translation.
The Case for Bible Translation, Viewed in Historical Perspective
Authors: Moore Richard K.
Published: March 2014

For eleven hundred years the Western church made the Bible available only in a Latin translation. Prior to this, however, there had been extensive Bible translating activity on three continents. With the sixteenth-century Reformation, the Reformers again made translation into the vernacular a priority, resulting in translations in various European languages. As the nations of Europe raced to colonize the rest of the world, especially in the nineteenth century, Protestant missionary activity among the peoples being colonized saw a third wave of Bible translation into their languages. Bible translation is one of the most effective mission tools.
Do Multilingual Speakers Understand the Bible Best in Their Heart Language? A Tool for Comparing Comprehension of Translations in Vernacular Languages and Languages of Wider Communication
Authors: Nehrbass Kenneth
Published: March 2014

It has been argued that speakers who are fluent in a vernacular and language of wider communication (LWC) will inevitably understand the Scriptures better in their “heart language.” I designed an experiment to determine the validity of that argument, using comprehension checks of seven passages in the New Testament that are difficult to comprehend. Preliminary results suggest that bilingual speakers performed better during checking sessions conducted in the LWC than they did while using the receptor language (RL), but their ability to identify key themes in either language was equivalent. While the experiment calls into question the validity of the “heart-language argument,” I conclude that there are several other more compelling reasons for producing vernacular Bible translations.
Antiochus IV as the Man Who Will Overflow the Flood and Break Its Arms (Daniel 11.22)
Authors: Scolnic Benjamin
Published: March 2014

Daniel 10–12 is a historical apocalypse, a vision of the end-time that first describes events of the Hellenistic period before predicting events in the future. Daniel 11.22 describes the accession of Antiochus IV to the Seleucid throne in symbolic terms. A translation of the verse should reflect its meaning and context.
Relationship of Vitamin D, HIV, HIV Treatment, and Lipid Levels in the Women’s Interagency HIV Study of HIV-Infected and Uninfected Women in the United States
Authors: Schwartz Janice B. , Moore Kelly L. , Yin Michael , Sharma Anjali , Merenstein Dan , Islam Talat , Golub Elizabeth T. , Tien Phyllis C. , Adeyemi Oluwatoyin M.
Published: March 2014

Relationships between vitamin D, lipids, HIV infection, and HIV treatment (±antiretroviral therapy [ART]) were investigated with Women’s Interagency HIV Study data (n = 1758 middle-aged women) using multivariable regression. Sixty-three percent of women had vitamin D deficiency. Median 25-hydroxyvitamin D (25-OH vitamin D) was highest in HIV-infected + ART-treated women (17 ng/mL; P < .001) and was the same in HIV-uninfected or HIV-infected women without ART (14 ng/mL). Vitamin D levels were lower if efavirenz (EFV) was included in ART (15 versus 19 ng/mL; P < .001). The most common lipid abnormality was high triglycerides (≥200 mg/dL) in HIV-infected + ART-treated women (13% versus 7% of HIV-infected without ART and 5% of HIV-uninfected; P < .001), with a positive relationship between 25-OH vitamin D and triglycerides (95% confidence interval 0.32-1.69; P < .01). No relationships between 25-OH vitamin D and cholesterol were detected. Vitamin D deficiency is common irrespective of HIV status but influenced by HIV treatment. Similarly, vitamin D levels were positively related to triglycerides only in ART-treated HIV-infected women and unrelated to cholesterol.
Prenatal Sonographic Detection of Skeletal Dysplasias
Authors: Bildner Amy
Published: March 2014

Skeletal dysplasias are a genetically heterogeneous group of disorders that can be diagnosed prenatally by sonography. Differentiating these disorders in the prenatal period can be difficult. However, differentiating known lethal disorders from nonlethal disorders can improve patient care and plan of action. This case study presents multiple pterygia, flexion contractures, and skeletal abnormalities, which are consistent with multiple pterygium syndrome, or Escobar syndrome.