bluuebunny/crossref_metadata_2025 huggingface dataset:
Temporal alteration of serum bilirubin levels and its renoprotective effects in diabetic kidney disease: exploring the hormonal mechanisms
Authors: Cao Can , Wei Shuwu , He Leijuan , Li Chunyao , Lu Yizhen , Sun Weiwei , Wang Yaoxian
Published: May 2024

Objective

This current study represents a novel endeavor to scrutinize the correlation between the temporal alteration in serum total bilirubin (TBIL) concentrations and the rate of estimated glomerular filtration rate (eGFR). Additionally, this study aims to probe the plausible molecular mechanism underpinning the renoprotective effects of bilirubin concerning its hormonal characteristics.

Materials and methods

In this study, a cohort of 103 patients diagnosed with DKD and receiving medical care at Dongzhimen Hospital were recruited and monitored over a period of 2-7 years. The progression of DKD was ascertained using a threshold of eGFR decline > -5.48%/year. To assess the relationship between the annual change in serum TBIL levels (%/year) and the slope of eGFR, multivariate binary logistic regression analysis was employed. Furthermore, the ROC curve analysis was employed to determine the cut-off value for TBIL levels (%/year).

Results

The use of multivariate binary logistic regression models revealed that serum TBIL levels (%/year) exhibited a significant correlation with the slope of eGFR. Moreover, the ROC curve analysis indicated a cut-off value of -6.729%/year for TBIL levels (%/year) with a sensitivity of 0.75 and specificity of 0.603, in diagnosing eGFR decline >-5.48%/year.

Conclusions

The findings of this study suggest that the sustained elevation of serum bilirubin concentration within the physiological range can effectively retard the progression of Diabetic Kidney Disease (DKD). Furthermore, the hormonal attributes of bilirubin may underlie its renoprotective effects.
Comparative mathematical modeling of causal association between metal exposure and development of chronic kidney disease
Authors: Wu Miaoling , Hou Weiming , Qin Ruonan , Wang Gang , Sun Da , Geng Ye , Du Yinke
Published: May 2024

Background

Previous studies have identified several genetic and environmental risk factors for chronic kidney disease (CKD). However, little is known about the relationship between serum metals and CKD risk.

Methods

We investigated associations between serum metals levels and CKD risk among 100 medical examiners and 443 CKD patients in the medical center of the First Hospital Affiliated to China Medical University. Serum metal concentrations were measured using inductively coupled plasma mass spectrometry (ICP-MS). We analyzed factors influencing CKD, including abnormalities in Creatine and Cystatin C, using univariate and multiple analysis such as Lasso and Logistic regression. Metal levels among CKD patients at different stages were also explored. The study utilized machine learning and Bayesian Kernel Machine Regression (BKMR) to assess associations and predict CKD risk based on serum metals. A chained mediation model was applied to investigate how interventions with different heavy metals influence renal function indicators (creatinine and cystatin C) and their impact on diagnosing and treating renal impairment.

Results

Serum potassium (K), sodium (Na), and calcium (Ca) showed positive trends with CKD, while selenium (Se) and molybdenum (Mo) showed negative trends. Metal mixtures had a significant negative effect on CKD when concentrations were all from 30th to 45th percentiles compared to the median, but the opposite was observed for the 55th to 60th percentiles. For example, a change in serum K concentration from the 25th to the 75th percentile was associated with a significant increase in CKD risk of 5.15(1.77,8.53), 13.62(8.91,18.33) and 31.81(14.03,49.58) when other metals were fixed at the 25th, 50th and 75th percentiles, respectively.

Conclusions

Cumulative metal exposures, especially double-exposure to serum K and Se may impact CKD risk. Machine learning methods validated the external relevance of the metal factors. Our study highlights the importance of employing diverse methodologies to evaluate health effects of metal mixtures.
Patterns of distant metastasis and survival outcomes in de novo metastatic breast cancer according to age groups
Authors: Liu Ke , Huang An-Le , Chen Xue-Qin , Wu San-Gang
Published: May 2024

Background

Is de novo metastatic breast cancer (dnMBC) the same disease in the elderly as in younger breast cancer remains unclear. This study aimed to determine the metastatic patterns and survival outcomes in dnMBC according to age groups.

Methods

We included patients from the Surveillance Epidemiology and End Results program. Chi-square test, multivariate logistic regression analyses, and multivariate Cox regression models were used for statistical analyses.

Results

A total of 17719 patients were included. There were 3.6% (n=638), 18.6% (n=3290), 38.0% (n=6725), and 39.9% (n=7066) of patients aged <35, 35-49, 50-64, and ≥65 years, respectively. Older patients had a significantly higher risk of lung metastasis and a significantly lower risk of liver metastasis. There were 19.1%, 25.6%, 30.9%, and 35.7% of patients with lung metastasis in those aged <35, 35-49, 50-64, and ≥65 years, respectively. Moreover, the proportion of liver metastasis was 37.6%, 29.5%, 26.3%, and 19.2%, respectively. Age was the independent prognostic factor associated with breast cancer-specific survival (BCSS) and overall survival (OS). Those aged 50-64 years had significantly inferior BCSS (P<0.001) and OS (P<0.001) than those aged <35 years. Patients aged ≥65 years also had significantly lower BCSS (P<0.001) and OS (P<0.001) than those aged <35 years. However, similar outcomes were found between those aged 35-49 and <35 years.

Conclusion

Our study suggests that different age groups may affect the metastatic patterns among patients with dnMBC and the survival of younger patients is more favorable than those of older patients.
Virtual inertia control to active support of the variable-speed wind turbine in variable frequency limit time
Authors: Tingyun Gu , Houyi Zhang , Bowen Li , Junyi Mao , Qiang Fan , Yutao Xu , Qihui Feng
Published: May 2024

Constraining the virtual inertia of variable-speed wind turbines within the variable frequency limit time will be the key to improving the wind power’s reliability in actively supporting the system frequency. First, this paper analyzes the controllable characteristics and evaluation methods of the virtual inertia of the wind turbine. Second, it quantifies the variable frequency limit time of the grid with high-proportion wind power and considers the wind turbine speed and power margin to restrict the virtual inertia of the wind turbine during the period of frequency drop or increase to provide reliable inertia support to ensure the safety of the system frequency. On this basis, the inertia demand under the frequency safety of the system was analyzed, and the virtual inertia control strategy of the variable-speed wind turbine in the variable frequency limit time was proposed using the speed tracking performance of the wind turbine. Finally, the grid with a high-proportion wind power simulation system is built to verify that the variable-speed wind turbine can reliably satisfy the inertia demand of system frequency modulation under the proposed control strategy and significantly improve its active support performance to the power grid.
Vision impairment and food insecurity in the national health and aging trends study
Authors: Lee Moon J. , Almidani Louay , Samuel Laura , Swenor Bonnielin K. , Ehrlich Joshua R. , Varadaraj Varshini
Published: May 2024

Introduction

Vision impairment (VI) may further exacerbate older adults’ vulnerability to experiencing food insecurity and may be a unique and important target for policies addressing access to nutritional food. The purpose of this study is to determine the association of VI in older adults with food insecurity.

Methods

This is a cross-sectional analysis of round 11 (2021) of the National Health and Aging Trends Study (NHATS), a nationally representative survey of U.S. Medicare beneficiaries ages 65 and older. Participants include 2,815 older adults with complete data on at least one objective measure of vision (distance, near or contrast sensitivity) and food insecurity. Food insecurity was assessed using a previously developed indicator of food insecurity in NHATS. VI was defined as binocular visual acuity (VA) worse than 0.3 logMAR (Snellen equivalent 20/40) at distance or its near equivalent, or contrast sensitivity (CS) worse than 1.55 logUnits. Continuous VI measures included distance and near VA (per 0.1 logMAR), and CS (per 0.1 logCS).

Results

Participants were majority White (82%) and female (55%), and 3% had food insecurity. Older adults with any VI had a greater prevalence of food insecurity than adults without VI (5.0% vs. 2.0%, p < 0.05). In fully adjusted regression analyses, individuals with any VI experienced double the odds of food insecurity than individuals without VI (OR: 2.1, 95% CI: 1.2–3.6). Distance VI (measured continuously) was associated with 1.2 times the odds of food insecurity (OR = 1.2; 95% CI: 1.0–1.3, per 0.1 logMAR). All other vision measures trended towards higher odds of food insecurity, though not statistically significant.

Discussion

Older adults with VI experience higher rates of food insecurity than their peers. Interventions to improve food security should be targeted towards addressing the specific barriers faced by visually impaired older adults.
Taxonomic and functional diversity of zooxanthellate corals and hydrocorals in Southwestern Atlantic reefs
Authors: Bleuel Jessica , Waechter Luiza , Bender Mariana , Longo Guilherme O.
Published: May 2024

The Southwestern Atlantic (SWA) harbors a relatively species poor but highly endemic coral assemblage due to historical processes, environmental and ecological drivers. Despite its low to moderate cover, corals still have a disproportionate contribution to ecosystem function and stability in this region. In the context of global change, it is imperative to know corals’ diversity and biogeographic patterns, yet a comprehensive approach is still missing for SWA corals. We integrated occurrence data from 21 sites and nine functional traits across 20 coral (scleractinian and hydrozoan) species to explore the taxonomic and functional diversity of coral assemblages in the SWA (1°N-27°S). We identified eight regions based on coral species composition, and then described their functional diversity using four metrics: functional richness (FRic), functional dispersion (FDis), functional evenness (FEve), and functional originality (FOri). Taxonomic and functional diversity peak between latitudes 13°S-20°S, decreasing with increasing distance from this diversity center, known as the Abrolhos Bank that harbors a wide continental platform. Our findings reveal a prevalent pattern of high functional redundancy across these eight regions (indicated by low functional originality), with species occupying the edges of the trait space (high functional evenness) and converging around few trait values (low functional dispersion). Such patterns resulted in low taxonomic and functional beta diversity and increased nestedness among regions caused by dispersal barriers and environmental filtering. The Southernmost region (24°-27°S) has the lowest taxonomic and functional diversity and comprises only two species that share similar traits, with these corals being: hermaphrodites, brooders and depth-tolerant, and having a wide corallite. As this region might become critical for corals in a future tropicalization scenario, tropical corals that share similar traits to those of the southernmost region can be more likely to thrive. Knowledge on taxonomic and functional diversity patterns can offer critical information to conservation by helping prioritizing areas with higher diversity and species with traits that enhance survival under climate change.
Morphological responses of root hairs to changes in soil and climate depend on plant life form
Authors: Zhou Yingtong , Wang Cunguo , Tang Qinrong , Wang Junni , Li Mai-He
Published: May 2024

Introduction

Root hairs increase the surface area of a plant’s root system that is in contact with the soil, thus facilitating plant water and nutrient uptake. However, little is known about the characteristics of the root hairs of herbaceous and woody plants and their specific response patterns to biotic and abiotic variables from the perspective of resource acquisition strategies in the context of global change.

Methods

Here, we analyzed 74 published case studies with 1074 observations of root hair traits to identify patterns of root hair length, density and diameter in relation to soil (e.g., soil pH, nutrient levels), growing environments (e.g., greenhouse, field) and climatic factors (e.g., air temperature), as well as genome size and plant age.

Results

Root hairs were longer, denser and thicker in woody plants compared with herbaceous plants, and the length and diameter of root hairs in herbaceous plants increased with genome size. With increasing plant age, woody plants had significantly longer and thicker root hairs, while root hair density and diameter declined significantly for herbaceous plants. Soil-cultured plants had longer root hairs than solution-cultured plants. The length and density of root hairs were greater in greenhouse-cultured plants than in field-grown plants, and the latter had thicker root hairs than the former. As soil pH increased, root hair length increased but diameter decreased in woody plants, while root hair density increased in herbaceous plants. Increased soil total nitrogen (N) and potassium (K) significantly increased root hair length, density and diameter in herbaceous plants, while soil total N significantly decreased root hair density in woody plants. Root hair length increased significantly, while root hair density decreased significantly, with higher mean annual temperature and greater precipitation seasonality, while the opposite pattern was true for a wider annual temperature range.

Discussion

Our findings emphasize the life-form-specific responses of root hairs to soil and climatic variables. These findings will help deepen our understanding of resource acquisition strategies and their mechanisms in different plant forms under global climate change.
Influence of metallic particles and TNF on the transcriptional regulation of NLRP3 inflammasome-associated genes in human osteoblasts
Authors: Sellin Marie-Luise , Hansmann Doris , Bader Rainer , Jonitz-Heincke Anika
Published: May 2024

Introduction

The release of mature interleukin (IL-) 1β from osteoblasts in response to danger signals is tightly regulated by the nucleotide-binding oligomerization domain leucine-rich repeat and pyrin-containing protein 3 (NLRP3) inflammasome. These danger signals include wear products resulting from aseptic loosening of joint arthroplasty. However, inflammasome activation requires two different signals: a nuclear factor-kappa B (NF-κB)-activating priming signal and an actual inflammasome-activating signal. Since human osteoblasts react to wear particles via Toll-like receptors (TLR), particles may represent an inflammasome activator that can induce both signals.

Methods

Temporal gene expression profiles of TLRs and associated intracellular signaling pathways were determined to investigate the period when human osteoblasts take up metallic wear particles after initial contact and initiate a molecular response. For this purpose, human osteoblasts were treated with metallic particles derived from cobalt-chromium alloy (CoCr), lipopolysaccharides (LPS), and tumor necrosis factor-alpha (TNF) alone or in combination for incubation times ranging from one hour to three days. Shortly after adding the particles, their uptake was observed by the change in cell morphology and spectral data.

Results

Exposure of osteoblasts to particles alone increased NLRP3 inflammasome-associated genes. The response was not significantly enhanced when cells were treated with CoCr + LPS or CoCr + TNF, whereas inflammation markers were induced. Despite an increase in genes related to the NLRP3 inflammasome, the release of IL-1β was unaffected after contact with CoCr particles.

Discussion

Although CoCr particles affect the expression of NLRP3 inflammasome-associated genes, a single stimulus was not sufficient to prime and activate the inflammasome. TNF was able to prime the NLRP3 inflammasome of human osteoblasts.
Krameria lappacea root extract’s anticoccidial properties and coordinated control of CD4 T cells for IL-10 production and antioxidant monitoring
Authors: Abdel-Gaber Rewaida , Alamari Ghada , Dkhil Mohamed A. , Meryk Andreas , Al-Shaebi Esam M. , Al-Quraishy Saleh
Published: May 2024

Introduction

Recently, the use of botanicals as an alternative to coccidiostats has been an appealing approach for controlling coccidiosis. Therefore, this study was conducted to evaluate the potential role of aqueous methanolic extract (200 mg/kg) of Krameria lappacea (roots) (KLRE) against infection induced by Eimeria papillata.

Methods

A total of 25 male C57BL/6 mice were divided into five groups (I, II, III, IV, and V). On 1st day of the experiment, all groups except groups I (control) and II (non-infected-treated group with KLRE), were inoculated orally with 103 sporulated E. papillata oocysts. On the day of infection, group IV was treated with KLRE. Group V served as an infected-treated group and was treated with amprolium (coccidiostat).

Results

Treatment with extract and coccidiostat was continued for five consecutive days. While not reaching the efficacy level of the reference drug (amprolium), KLRE exhibited notable anticoccidial activity as assessed by key criteria, including oocyst suppression rate, total parasitic stages, and maintenance of nutrient homeostasis. The presence of phenolic and flavonoid compounds in KLRE is thought to be responsible for its positive effects. The Eimeria infection increased the oxidative damage in the jejunum. KLRE treatment significantly increased the activity of catalase and superoxide dismutase. On the contrary, KLRE decreased the level of malondialdehyde and nitric oxide. Moreover, KLRE treatment decreased macrophage infiltration in the mice jejunal tissue, as well as the extent of CD4 T cells and NFkB. E. papillata caused a state of systemic inflammatory response as revealed by the upregulation of inducible nitric oxide synthase (iNOs)-mRNA. Upon treatment with KLRE, the activity of iNOs was reduced from 3.63 to 1.46 fold. Moreover, KLRE was able to downregulate the expression of pro-inflammatory cytokines interferon-γ, nuclear factor kappa B, and interleukin-10 -mRNA by 1.63, 1.64, and 1.38 fold, respectively. Moreover, KLRE showed a significant reduction in the expression of IL-10 protein level from 104.27 ± 8.41 pg/ml to 62.18 ± 3.63 pg/ml.

Conclusion

Collectively, K. lappacea is a promising herbal medicine that could ameliorate the oxidative stress and inflammation of jejunum, induced by E. papillata infection in mice.
Asexual proliferative seedling technology for Sargassum fusiforme constructed using tissue culture method
Authors: Guo Lina , Pang Guanfeng , Luo Lin , Gao Congquan , Chen Binbin , Ma Zengling
Published: May 2024

The traditional method of sexual reproduction in Sargassum fusiforme can lead to difficulties in maintaining the stable inheritance of superior traits. However, technology for asexual proliferation of seedlings in seaweed tissue culture is not well-developed. Therefore, we established a tissue culture method to study, the effects of different parts of S. fusiforme, uniconazole (UIZ) concentrations, and culture methods on the regeneration of tissue-derived juveniles of S. fusiforme. The results showed that the optimal culture conditions were solid medium with modified Provassoli’s enriched seawater containing 3 μM UIZ for at least 17 days followed by transfer to liquid medium to induce rapid cell proliferation. These optimal conditions resulted in a callus-like/adventitious bud induction rate of 100%, callus-like/adventitious bud number per explant of 27.43 ± 4.57, and relative growth rate of 3.05 ± 0.27. The best plant parts for tissue culture were the filamentous holdfasts followed by the stem tip. In addition, UIZ treatment increased photosynthesis, resulting in soluble sugar and soluble protein contents of 30.47 mg·g-1 and 1.39 mg·g-1 of in the regenerated juveniles. Based on our results, S. fusiforme can be cultured using a tissue culture technique in which UIZ is added to a solid medium, followed by culture in liquid medium for proliferation. Sargassum fusiforme juveniles obtained using this technique can be cultured continuously until the next culture season and grow normally, providing a technical reference for indoor preservation and expansion of algal species.
Posterior reversible encephalopathy syndrome post stem cell transplantation in sickle cell disease: case series and literature review
Authors: BinAmir Hussain A. , AlAhmari Ali , AlQahtani AlWaleed , Mohamed Gamal , Alotaibi Fawaz , AlShamrani Mohamed , AlSaeed Ali , AlGhanmi Suwaidi , Heji Alaa , Alreshaid Abdulrahman , AlKawi Ammar , AlHazzani Adel , AlZawahmah Mohamed , Shuaib Ashfaq , Al-Ajlan Fahad , AlMohareb Fahad
Published: May 2024

Introduction

Posterior reversible encephalopathy syndrome (PRES) is a serious neurological syndrome that may develop following immunosuppressive therapy for stem cell transplantation (SCT). We report 8 patients with sickle cell disease (SCD) who developed PRES, which is likely to be related to immunosuppression.

Methods

This is retrospective cohort analysis of the SCD registry at the King Faisal Specialist Hospital and Research Center (KFSHRC) in Riyadh, Saudi Arabia. Inclusion criteria included all adults SCD patients who underwent SCT from 2011 until 2022. We explored all cases of PRES in patients with SCT. PRES was diagnosed with MRI imaging showing reversible vasogenic cerebral edema associated with neurological symptoms including severe headache, seizures, encephalopathy, delirium, and visual disturbances.

Results

During ten years follow-up (2011–2022) we found 8 patients with PRES (age range between 14 to 37 years at diagnosis) PRES occurred 8 to 124 days following SCT in 7 cases and one patient developed PRES 8 months prior to SCT. All patients were on immunosuppressive medications, including tacrolimus, cyclosporine, sirolimus and or mycophenolate mofetil. Headache, seizures, visual hallucinations, confusion, and drowsiness were the most common presenting symptoms. MRI showed abnormalities in the occipital, parietal and frontal lobes in most cases. Recovery was complete in all patients and no recurrences were noted. Two patients had graft versus host disease (GVHD). We compared risk factors for PRES among the 8 cases and 136 SCT in SCD patients who did not develop PRES. There was a significant association between PRES and imaging abnormalities, including previous bi-hemispheric infarctions (p = 0.001), and cerebral microbleeds (CBMs). PRES was strongly associated with presence (p = 0.006), size (p = 0.016) and number (p = 0.005) of CMBs.

Conclusion

PRES can develop days to weeks following SCT in patients with SCD, and is associated with immunosuppressive therapy, previous bi-hemispheric infarctions and CMB. Prompt recognition and intervention leads to good recovery.
Rare microbial taxa as the major drivers of nutrient acquisition under moss biocrusts in karst area
Authors: Dong Xintong , Chen Man , Chen Qi , Liu Kangfei , Long Jie , Li Yunzhou , Ren Yinuo , Yang Tao , Zhou Jinxing , Herath Saman , Peng Xiawei
Published: May 2024

Karst rocky desertification refers to the process of land degradation caused by various factors such as climate change and human activities including deforestation and agriculture on a fragile karst substrate. Nutrient limitation is common in karst areas. Moss crust grows widely in karst areas. The microorganisms associated with bryophytes are vital to maintaining ecological functions, including climate regulation and nutrient circulation. The synergistic effect of moss crusts and microorganisms may hold great potential for restoring degraded karst ecosystems. However, our understanding of the responses of microbial communities, especially abundant and rare taxa, to nutrient limitations and acquisition in the presence of moss crusts is limited. Different moss habitats exhibit varying patterns of nutrient availability, which also affect microbial diversity and composition. Therefore, in this study, we investigated three habitats of mosses: autochthonal bryophytes under forest, lithophytic bryophytes under forest and on cliff rock. We measured soil physicochemical properties and enzymatic activities. We conducted high-throughput sequencing and analysis of soil microorganisms. Our finding revealed that autochthonal moss crusts under forest had higher nutrient availability and a higher proportion of copiotrophic microbial communities compared to lithophytic moss crusts under forest or on cliff rock. However, enzyme activities were lower in autochthonal moss crusts under forest. Additionally, rare taxa exhibited distinct structures in all three habitats. Analysis of co-occurrence network showed that rare taxa had a relatively high proportion in the main modules. Furthermore, we found that both abundant and rare taxa were primarily assembled by stochastic processes. Soil properties significantly affected the community assembly of the rare taxa, indirectly affecting microbial diversity and complexity and finally nutrient acquisition. These findings highlight the importance of rare taxa under moss crusts for nutrient acquisition. Addressing this knowledge gap is essential for guiding ongoing ecological restoration projects in karst rocky desertification regions.
A scale-free model of acute and ventilator-induced lung injury: a network theory approach inspired by seismology
Authors: Gottman Drew C. , Smith Bradford J.
Published: May 2024

Introduction

Acute respiratory distress syndrome (ARDS) presents a significant clinical challenge, with ventilator-induced lung injury (VILI) being a critical complication arising from life-saving mechanical ventilation. Understanding the spatial and temporal dynamics of VILI can inform therapeutic strategies to mitigate lung damage and improve outcomes.

Methods

Histological sections from initially healthy mice and pulmonary lavage-injured mice subjected to a second hit of VILI were segmented with Ilastik to define regions of lung injury. A scale-free network approach was applied to assess the correlation between injury regions, with regions of injury represented as ‘nodes’ in the network and ‘edges’ quantifying the degree of correlation between nodes. A simulated time series analysis was conducted to emulate the temporal sequence of injury events.

Results

Automated segmentation identified different lung regions in good agreement with manual scoring, achieving a sensitivity of 78% and a specificity of 85% across ‘injury’ pixels. Overall accuracy across ‘injury’, ‘air’, and ‘other’ pixels was 81%. The size of injured regions followed a power-law distribution, suggesting a ‘rich-get-richer’ phenomenon in the distribution of lung injury. Network analysis revealed a scale-free distribution of injury correlations, highlighting hubs of injury that could serve as focal points for therapeutic intervention. Simulated time series analysis further supported the concept of secondary injury events following an initial insult, with patterns resembling those observed in seismological studies of aftershocks.

Conclusion

The size distribution of injured regions underscores the spatially heterogeneous nature of acute and ventilator-induced lung injury. The application of network theory demonstrates the emergence of injury ‘hubs’ that are consistent with a ‘rich-get-richer’ dynamic. Simulated time series analysis demonstrates that the progression of injury events in the lung could follow spatiotemporal patterns similar to the progression of aftershocks in seismology, providing new insights into the mechanisms of injury distribution and propagation. Both phenomena suggest a potential for interventions targeting these injury ‘hubs’ to reduce the impact of VILI in ARDS management.
Association of future cancer metastases with fibroblast activation protein-α: a systematic review and meta-analysis
Authors: Janani Majid , Poorkhani Amirhoushang , Amiriani Taghi , Donyadideh Ghazaleh , Ahmadi Farahnazsadat , Jorjanisorkhankalateh Yalda , Beheshti-Nia Fereshteh , Kalaei Zahra , Roudbaraki Morad , Soltani Mahsa , Khori Vahid , Alizadeh Ali Mohammad
Published: May 2024

Introduction

Fibroblast activation protein-α (FAP-α) is a vital surface marker of cancer-associated fibroblasts, and its high expression is associated with a higher tumor grade and metastasis. A systematic review and a meta-analysis were performed to associate future metastasis with FAP-α expression in cancer.

Methods

In our meta-analysis, relevant studies published before 20 February 2024 were systematically searched through online databases that included PubMed, Scopus, and Web of Science. The association between FAP-α expression and metastasis, including distant metastasis, lymph node metastasis, blood vessel invasion, vascular invasion, and neural invasion, was evaluated. A pooled odds ratio (OR) with 95% confidence intervals (CI) was reported as the measure of association.

Results

A total of 28meta-analysis. The random-effects model for five parameters showed that a high FAP-α expression was associated with blood vessel invasion (OR: 3.04, 95% CI: 1.54–5.99, I2 = 63%, P = 0.001), lymphovascular invasion (OR: 3.56, 95% CI: 2.14–5.93, I2 = 0.00%, P < 0.001), lymph node metastasis (OR: 2.73, 95% CI: 1.96–3.81, I2 = 65%, P < 0.001), and distant metastasis (OR: 2.59; 95% CI: 1.16–5.79, I2 = 81%, P < 0.001). However, our analysis showed no statistically significant association between high FAP-α expression and neural invasion (OR: 1.57, 95% CI: 0.84–2.93, I2 = 38%, P = 0.161).

Conclusions

This meta-analysis indicated that cancer cells with a high FAP-α expression have a higher risk of metastasis than those with a low FAP-α expression. These findings support the potential importance of FAP-α as a biomarker for cancer metastasis prediction.
Spiritual well-being and associated factor among adult cancer patients in Hawassa University Comprehensive Specialized Hospital, Oncology Center, Hawassa, Ethiopia
Authors: Kebede Fekadu Abera , Tafesse Bontu Hailu , Moga Fikre , Haile Addisalem , Zerihun Ebisa
Published: May 2024

Background

Spiritual well-being has been shown to boost resistance to mental health crises in cancer patients during the diagnosis and treatment process, but there is a paucity of studies about spirituality in cancer patients, which may make it difficult for healthcare clinicians to assess spirituality and provide spiritual care.

Objective

The aim of this study was to assess the level of spiritual well-being and associated factors among cancer patients in HUCSH Oncology Center in 2022.

Methods and materials

An institution-based cross-sectional study was done from May 30 to June 30, 2022 among 267 cancer patients, and the respondents were selected by a simple random sampling technique. Data was collected by using standardized interviewer-administered questionnaires (FACIT sp12). Data was entered using Epi data version 4.6, and analysis was carried out by using Statistical Package for Social Science version 25. Bivariate and multivariate logistic regression was conducted to determine the relationship between the independent and dependent variables. The strength of association was tested by using p-value at 95% CI. Ethical clearance was obtained from the Institutional Review Board of Hawassa University College of Medicine and Health Science. During data collection, the purpose of the study was clearly explained to the patients, and consent was obtained.

Result

A total of 267 cancer patients were included in the study. There was 100% response rate. Majority of the patients (80.5%) were in a poor spiritual well-being state. Mental distress (AOR = 0.246; 95% CI: 0.114–0.531) and religious education (AOR = 1.288; 95% CI: 1.438–9.142) were factors significantly associated with spiritual well-being among cancer patients.

Conclusion and recommendation

This study showed that more than two-thirds of patients had poor spiritual well-being. Mental distress and religious education were factors associated with spiritual well-being. Attention should be given by nurses of the center for spiritual well-being assessment in clinical practices favoring holistic care in the center.
Oxygen in the neonatal ICU: a complicated history and where are we now?
Authors: Mamidi Rachna R. , McEvoy Cindy T.
Published: May 2024

Despite major advances in neonatal care, oxygen remains the most commonly used medication in the neonatal intensive care unit (NICU). Supplemental oxygen can be life-saving for term and preterm neonates in the resuscitation period and beyond, however use of oxygen in the neonatal period must be judicious as there can be toxic effects. Newborns experience substantial hemodynamic changes at birth, rapid energy consumption, and decreased antioxidant capacity, which requires a delicate balance of sufficient oxygen while mitigating reactive oxygen species causing oxidative stress. In this review, we will discuss the physiology of neonates in relation to hypoxia and hyperoxic injury, the history of supplemental oxygen in the delivery room and beyond, supporting clinical research guiding trends for oxygen therapy in neonatal care, current practices, and future directions.
Synergy of botanical drug extracts from Dracaena cochinchinensis stemwood and Ardisia elliptica fruit in multifunctional effects on neuroprotection and anti-inflammation
Authors: Ospondpant Dusadee , Lai Queenie Wing Sze , Dong Tina Tingxia , Tsim Karl Wah Keung
Published: May 2024

Combination therapy is one of the promising approaches in developing therapeutics to cure complex diseases, such as Alzheimer’s disease (AD). In Thai traditional medicines, the clinical application often comprises multiple botanical drugs as a formulation. The synergistic interactions between botanical drugs in combination therapies are proposed to have several advantages, including increased therapeutic efficacy, and decreased toxicity and/or adverse effects. This study aimed to explore the therapeutic functions of a botanical hybrid preparation (BHP) of two botanical drugs within a traditional multi-herbal formulation. The synergistic actions of BHP of Dracaena cochinchinensis stemwood (DCS) and Ardisia elliptica fruit (AEF) at a specific ratio of 1:9 w/w were illustrated in neuroprotection and anti-inflammation. In cultured PC12 cells, BHP of DCS and AEF showed synergistic functions in inducing neuronal differentiation, characterized by neurofilament expression and neurite outgrowth. In addition, BHP of DCS and AEF exhibited a synergistic effect in inhibiting the aggregation of Aβ, a hallmark of AD pathology. The activated BV2 microglial cells induced by LPS were synergistically suppressed by the BHP of DCS and AEF, as evaluated by the expression of pro-inflammatory markers, including TNF-α, IL-1β, and iNOS, as well as the morphological change of microglial cells. The findings suggested that the effects of BHP of DCS and AEF were greater than individual botanical drugs in a specific ratio of 1:9 w/w to enhance neuroprotective and anti-inflammatory functions.
Filial responsibilities and psychological wellbeing among Chinese adolescents in poor single-mother families: does parental warmth matter?
Authors: Leung Janet T. Y. , Shek Daniel T. L.
Published: May 2024

Introduction

Adolescent children raised in single-mother households, particularly those living in poverty, often need to assume more instrumental and emotional familial responsibilities to cope with family challenges.

Method

This study examined the relationships between these filial responsibilities and adolescent psychological wellbeing, as well as the moderating effect of maternal warmth on these relationships via survey. The sample comprised 325 Chinese adolescent children (43.3% girls; Mage = 13.5) from economically disadvantaged single-mother families in Hong Kong.

Results

The results indicated that adolescents’ instrumental filial responsibilities were positively associated with their life satisfaction. Emotional filial responsibilities, on the other hand, were positively linked to life satisfaction and negatively associated with depression. Furthermore, maternal warmth was found to moderate the relationship between emotional filial responsibilities and life satisfaction. Adolescents who perceived higher levels of maternal warmth and performed more emotional filial responsibilities reported greater life satisfaction than those who performed fewer such responsibilities. Furthermore, the moderating effect of maternal warmth on the relationship between instrumental filial responsibilities and life satisfaction varied between boys and girls. Additionally, the age of the adolescent moderated the effect of maternal warmth on the relationship between emotional filial responsibilities and adolescent anxiety.

Discussion

These findings suggest that filial responsibilities do not necessarily impede adolescent wellbeing. Instead, maternal warmth appears to be a crucial family factor that influences the nature of the relationship between filial responsibilities and adolescent wellbeing. These insights are valuable for family scholars and practitioners, informing the design of supportive services to enhance the psychological wellbeing of Chinese adolescents from economically disadvantaged single-mother families.
Identifying links between athletic identity and risk factors related to youth sport participation
Authors: Choudhury M. Minnat , Erdman Ashley L. , Stapleton Emily , Gale Emily , Ulman Sophia
Published: May 2024

Introduction

The development of identity formation occurs during adolescence through experiences, ideals and principle. With greater accessibility to sports, recent trends have shown increased rates of sports specialization over the past decade in youth athletes. Athletic identity measures the strength an individual is tied to the athlete role and can be formed in conjunction to adolescent identity formation. More specialized youth athletes may have stronger ties to their athletic identity during their adolescent identity formation period.

Methods

Youth basketball athletes were surveyed on specialization levels and athletic identity via the Athletic Identity Measurement Scale (AIMS), including three submeasures: social identity, exclusivity, and negative affectivity.

Results

Participants showed stronger identification to social identity items and the weakest identification with exclusivity items. Athletes reporting more time spent playing their primary sport presented higher scores across all measures of athletic identity, and total athletic identity was stronger in athletes reporting specialization at an earlier age. Exclusivity and negative affectivity tended to increase with specialization level which may primarily be driven by specialized athletes choosing to quit non-primary sports.

Discussion

Athletic identity may be worth noting as a psychological indicator of potential risk of injury. The long-term goal of this work is to provide the research and clinical community a greater understanding of a potential psychosocial risk factor as youth athletes continue specializing and spending more time training in a singular sport.
Associations between social network addiction, anxiety symptoms, and risk of metabolic syndrome in Peruvian adolescents—a cross-sectional study
Authors: Saintila Jacksaint , Oblitas-Guerrero Susan M. , Larrain-Tavara Giovanna , Lizarraga-De-Maguiña Isabel G. , Bernal-Corrales Fátima del Carmen , López-López Elmer , Calizaya-Milla Yaquelin E. , Serpa-Barrientos Antonio , Ramos-Vera Cristian
Published: May 2024

Background

The link between physical and mental health and screen time in adolescents has been the subject of scientific scrutiny in recent years. However, there are few studies that have evaluated the association between social network addiction (SNA) and metabolic risk in this population.

Objective

This study determined the association between SNA and anxiety symptoms with the risk of metabolic syndrome (MetS) in adolescents.

Methods

A cross-sectional study was conducted in Peruvian adolescents aged 12 to 18 years, who completed a Social Network Addiction Questionnaire and the Generalized Anxiety Disorder 2-item scale (GAD-2), between September and November 2022. A total of 903 participants were included in the study using a non-probability convenience sample. Sociodemographic and anthropometric data were also collected. Binary logistic regression was used to explore the association between SNA and anxiety symptoms with MetS in a cross-sectional analysis.

Results

Males were more likely to have MetS than females (OR = 1.133, p = 0.028). Participants who were 16 years of age or older and those with excess body weight were 2.166, p = 0.013 and 19.414, p < 0.001 times more likely to have MetS, respectively. Additionally, SNA (OR = 1.517, p = 0.016) and the presence of anxiety symptoms (OR = 2.596, p < 0.001) were associated with MetS.

Conclusion

Our findings suggest associations between SNA, anxiety symptoms, and MetS among youth. However, more studies are needed to better understand this association and to deepen the possible clinical and public health implications.
Prevalence of Salmonella spp., Shigella spp., and intestinal parasites among food handlers working in University of Gondar student’s cafeteria, Northwest Ethiopia
Authors: Amare Azanaw , Eshetie Setegn , Kasew Desie , Amare Ayenew , Abebe Wondwossen , Moges Feleke
Published: May 2024

Background

Food-borne infections continue to be a major public health problem at the international level. The issue becomes more serious in developing countries like Ethiopia.

Objective

This study aimed to examine the prevalence of Salmonella and Shigella species and intestinal parasites, as well as antimicrobial resistance patterns and associated factors among food handlers at the University of Gondar cafeteria in northwest Ethiopia.

Methods

An institutional-based cross-sectional study was conducted from February to June 2021 in the University of Gondar cafeterias. Data related to the socio-demographic characteristics and hygienic practices of study participants were collected using structured questionnaires. A total of 290 stool samples were collected from food handlers. Culture and conventional biochemical tests were used to isolate the Salmonella and the Shigella species. Wet mount, Formol-ether concentration, and Kato Katz techniques were applied to identify intestinal parasites. Additionally, drug susceptibility tests were performed using the disk diffusion method. Statistical analysis was done using SPSS version 26.

Results

Of 290 food handlers’ stool samples analyzed, Twenty-seven 27 (9.3%) were positive for both Salmonella and Shigella species. The prevalence of Salmonella and Shigella species was 16 (5.5%) and 11 (3.8%), respectively. Most of the isolated pathogens were resistant to tetracycline 19 (70.4%), and trimethoprim/sulphamethoxazole 19 (70.4%). The overall rate of multi-drug resistant Shigella and Salmonella isolate was 59.3%. Besides, Fifty-seven 57 (19.7%) of the participants were positive for one or more intestinal parasites. The most prevalent intestinal Parasitosis was E. histolytica/dispar 22 (7.6%), followed by G. lamblia 13 (4.5%), and Ascaris lumbricoides 11 (3.8) not washing hands after using the toilet (AOR: 4.42, 95% CI: 1.57, 10.56), and consuming unpasteurized milk (AOR: 3.14, 95% CI: 1.65, 3.96), were factors significantly associated with the prevalence of Salmonella, and Shigella infection. Similarly, not washing hands after using the toilet (AOR: 2.19, 95% CI: 1.0, 1.4), and consuming unpasteurized milk (AOR: 10.4, 95% CI: 3.8, 28.8), were factors significantly associated with the prevalence of intestinal parasites infection.

Conclusion

The prevalence of intestinal parasites, Salmonella, and Shigella species was high. Therefore, it is imperative to implement a public health policy that includes ongoing microbiological surveillance.
What Are Barrier Islands and How Are They Affected by Climate Change?
Authors: Riffe Emily C. , Canfield Megan , Sabo Alexander B. , White Andrew E. , Zinnert Julie C.
Published: May 2024

Barrier islands are complex ecosystems that exist off the coast of every continent except Antarctica. They protect the coastline from direct impacts of storms and sea-level rise. These islands are home to people and animals, some of which are endangered. Barrier islands naturally move and change shape, but climate change and human development can prevent this movement, disrupting natural processes. Conservation of barrier islands is important for providing habitats for plants and animals as well as for protecting the coast of the mainland.
What determines voting behavior to host the Olympic games in the Rhine-Ruhr area: a multilevel model
Authors: Menge John A. , Bühren Christoph , Schlesinger Torsten
Published: May 2024

This study analyzes factors influencing public support for hosting the Summer Olympics in the Rhine-Ruhr (RR) region in 2036 or 2040. Analyzing data from 14 municipalities, a multilevel model is used to account for individual and contextual factors. Despite a high overall endorsement rate of 67%, the study shows that consumer capital, pride, perception of sustainability, and historical significance significantly influence voting behavior. Surprisingly, structural factors at the municipal level do not show a significant influence. This research provides valuable insights for policymakers and organizers considering future Olympic bids in the RR region. The results emphasize the importance of effective communication to gain public support. This communication should highlight the environmental and economic sustainability of the host community, historical significance, and intangible benefits such as pride.