bluuebunny/crossref_metadata_2025 huggingface dataset:
A Curious Problem in the Renovation of the Christian Building at Dura-Europos: Reconstructing the Use of Water in the Durene Baptismal Rite and its Ritual Significance
Authors: Berg Karl
Published: September 2023

Abstract: Situating the Christian building of Dura-Europos within its ambient domestic context accentuates a curious problem: During the renovation in which the Christians of Dura converted this building into a worship space, this community installed a large water basin, presumably used for baptism. Yet concurrent with this transformation, Dura's Christians also paved over their house's cistern, located in the adjacent courtyard. Thus, as the Durene Christian community was installing a baptismal basin—a feature which required water—these Christians enigmatically removed the most convenient means by which they could have secured water to fill that basin. The following study aims to reconstruct how the Christians of Dura procured water for use in their baptismal rite and to examine why these Christians might have removed access to their cistern while simultaneously installing a baptismal basin. Recent scholarship on Dura has provided a sound footing for this examination by allowing the use of water at Dura to be reconstructed with substantial clarity. Examining the Christian building's transformation in light of this scholarship allows the Durene Christians' rejection of cistern water for use in their ritual of baptism to be situated comfortably within documented early Christian preferences to baptize in naturally-flowing waters.
Saint Stephen in Africa: On Saints, Spinsters, and Synagogues in Late Antiquity
Authors: Sivan Hagith
Published: September 2023

Abstract: This study forges a novel link between an image molded unto an oil lamp from Carthage and the text that inspired it. Wrongly considered unique and misinterpreted for over a century, the lamp features a hallowed figure holding a cross in its right arm and crushing a serpent-dragon under its feet. This triad—man, cross, beast—is planted atop an inverted seven-branch candelabra, the ubiquitous Jewish symbol of Late Antiquity. Behind the story of the pictured saint simultaneously subduing a dragon and a candelabra is a tradition of vehement anti-Judaism based on the New Testament and richly laced with African theology and martyrology. Using as interpretative keys a group of oil lamps manufactured in North Africa for Christian and Jewish customers, this study traces the evolution of new, peculiarly African discourses of sainthood, of martyrdom, and of Jewishness.
High-efficient subwavelength structure engineered grating couplers for 2-µm waveband high-speed data transmission
Authors: Hu Yueyang , He Wenchang , Sun Yuhan , Yi Qiyuan , Xing Sizhe , Yan Zhiwei , Xia Lipeng , Li Ting , Zhou Peiji , Zhang Junwen , Shen Li , Zou Yi
Published: September 2023

The 2-µm waveband is becoming an emerging window for next-generation high-speed optical communication. To enable on-chip high-speed data transmission, improving the signal-to-noise ratio (SNR) by suppressing the coupling loss of a silicon chip is critical. Here, we report grating couplers for TE and TM polarized light at the 2-µm waveband. With a single-step fully etched process on the 340 nm silicon-on-insulator (SOI) platform, the devices experimentally demonstrate high coupling efficiency of -4.0 dB and 1-dB bandwidth of 70 nm for the TE polarized light, while -4.5 dB coupling efficiency and 58 nm 1-dB bandwidth for the TM polarized light. For comprehensive performance, both of them are among the best grating couplers operating in the 2-µm waveband so far. We also demonstrate 81Gbps high-speed on-chip data transmission using pulse amplitude modulation 8-level (PAM-8) signals.
Machine learning prediction of the total duration of invasive and non-invasive ventilation During ICU Stay
Authors: Schwager Emma , Liu Xinggang , Nabian Mohsen , Feng Ting , French Robin MacDonald , Amelung Pam , Atallah Louis , Badawi Omar
Published: September 2023

Predicting the duration of ventilation in the ICU helps in assessing the risk of ventilator-induced lung injury, ensuring sufficient oxygenation, and optimizing resource allocation. Prior models provided a prediction of total duration without distinguishing between invasive and non-invasive ventilation. This work proposes two independent gradient boosting regression models for predicting the duration of invasive and non-invasive ventilation based on commonly available ICU features. These models are trained on 2.6 million patient stays across 350 US hospitals between 2010 to 2019. The mean absolute error (MAE) for the prediction of duration was 2.08 days for invasive ventilation and 0.36 days for non-invasive ventilation. The total ventilation duration predicted by our model had MAE of 2.38 days, which outperformed the gold standard (APACHE) with MAE of 3.02 days. The feature importance analysis of the trained models showed that, for invasive ventilation, high average heart rate, diagnosis of respiratory infection and admissions from locations other than the operating room were associated with longer ventilation durations. For non-invasive ventilation, higher respiratory rates and having any GCS measurement were associated with longer durations.
Histone methylation regulates reproductive diapause in Drosophila melanogaster
Authors: DiVito Evans Abigail , Fairbanks Regina A. , Schmidt Paul , Levine Mia T.
Published: September 2023

Fluctuating environments threaten fertility and viability. To better match the immediate, local environment, many organisms adopt alternative phenotypic states, a phenomenon called “phenotypic plasticity.” Natural populations that predictably encounter fluctuating environments tend to be more plastic than conspecific populations that encounter a constant environment, suggesting that phenotypic plasticity can be adaptive. Despite pervasive evidence of such “adaptive phenotypic plasticity,” gene regulatory mechanisms underlying plasticity remains poorly understood. Here we test the hypothesis that environment-dependent phenotypic plasticity is mediated by epigenetic factors. To test this hypothesis, we exploit the adaptive reproductive arrest ofDrosophila melanogasterfemales, called diapause. Using an inbred line from a natural population with high diapause plasticity, we demonstrate that diapause is determined epigenetically: only a subset of genetically identical individuals enter diapause and this diapause plasticity is epigenetically transmitted for at least three generations. Upon screening a suite of epigenetic marks, we discovered that the active histone marks H3K4me3 and H3K36me1 are depleted in diapausing ovaries. Using ovary-specific knockdown of histone mark writers and erasers, we demonstrate that H3K4me3 and H3K36me1 depletion promotes diapause. Given that diapause is highly polygenic, that is, distinct suites of alleles mediate diapause plasticity across distinct genotypes, we also investigated the potential for genetic variation in diapause-determining epigenetic marks. Specifically, we asked if these histone marks were similarly depleted in diapause of a genotypically distinct line. We found evidence of divergence in both the gene expression program and histone mark abundance. This study reveals chromatin determinants of phenotypic plasticity and suggests that these determinants may be genotype-dependent, offering new insight into how organisms may exploit and evolve epigenetic mechanisms to persist in fluctuating environments.
Vegan versus meat-based cat food: Guardian-reported health outcomes in 1,369 cats, after controlling for feline demographic factors
Authors: Knight Andrew , Bauer Alexander , Brown Hazel
Published: September 2023

Increasing concerns about environmental sustainability, farmed animal welfare and competition for traditional protein sources, are driving considerable development of alternative pet foods. These include raw meat diets, in vitro meat products, and diets based on novel protein sources including terrestrial plants, insects, yeast, fungi and potentially seaweed. To study health outcomes in cats fed vegan diets compared to those fed meat, we surveyed 1,418 cat guardians, asking about one cat living with them, for at least one year. Among 1,380 respondents involved in cat diet decision-making, health and nutrition was the factor considered most important. 1,369 respondents provided information relating to a single cat fed a meat-based (1,242–91%) or vegan (127–9%) diet for at least a year. We examined seven general indicators of illness. After controlling for age, sex, neutering status and primary location via regression models, the following risk reductions were associated with a vegan diet for average cats: increased veterinary visits– 7.3% reduction, medication use– 14.9% reduction, progression onto therapeutic diet– 54.7% reduction, reported veterinary assessment of being unwell– 3.6% reduction, reported veterinary assessment of more severe illness– 7.6% reduction, guardian opinion of more severe illness– 22.8% reduction. Additionally, the number of health disorders per unwell cat decreased by 15.5%. No reductions were statistically significant. We also examined the prevalence of 22 specific health disorders, using reported veterinary assessments. Forty two percent of cats fed meat, and 37% of those fed vegan diets suffered from at least one disorder. Of these 22 disorders, 15 were most common in cats fed meat, and seven in cats fed vegan diets. Only one difference was statistically significant. Considering these results overall, cats fed vegan diets tended to be healthier than cats fed meat-based diets. This trend was clear and consistent. These results largely concur with previous, similar studies.
Menopausal experiences of women of Chinese ethnicity: A meta-ethnography
Authors: Kabir Md Ruhul , Chan Kara
Published: September 2023

Objective

Menopause and the changes it brings to a woman’s life necessitate a comprehensive approach to face and experience the transition. This paper aims at synthesizing results from qualitative studies of menopausal experiences among Chinese and other women of similar ethnicity and culture.

Design and method

A comprehensive search strategy of multiple databases along with bibliographic hand searches was employed to identify qualitative studies published in English peer-reviewed journals between 2008 and 2022 focused on the menopausal experiences (peri and post-menopause) of Chinese and other women of similar ethnic backgrounds. Twelve studies met the inclusion criteria. The final sample consisted of 238 women aged between 40 to 60 years who had experienced menopausal symptoms. This qualitative systematic literature review adopted Noblit and Hare’s seven-stage theoretical meta-ethnographic approach to construct an inductive and interpretive form of synthesis and subsequent analysis.

Syntheses of findings

The synthesis of primary data identified four key concepts that entitle women’s menopausal experiences: being menopausal, ramifications on well-being, family and social support around menopause, and healthcare throughout menopause. The subsequent second-order interpretation revealed that women accepted the inevitability of the natural aging process in the decline of sexual drive, reinvented relationships with partners, and expressed the significance of a supportive environment in order to successfully navigate the transition. Third-order interpretations sought to establish a link between physiological complications, loss of femininity, patriarchal-dominated societal norms, and a support system that spans the entire menopause experience. Healthcare’s contribution has also been deemed to be insufficient due to a lack of information and empathy from health experts. Negligence or reluctance to seek healthcare and skepticism toward hormone replacement therapy (HRT) had also been a source of concern, as they have had the potential to exacerbate medical difficulties and emotional turmoil.

Conclusions and implications for practice

A comprehensive approach that considers women’s physiological and psychological well-being and major attempts to change cultural beliefs and norms about women’s sexual health may be effective in aiding menopausal women during their transition. Additionally, appropriate guidelines and management should be in place to enable women to address menopause difficulties effectively with the assistance of healthcare experts and the support of their families and community.
Complete genome assembly of Hawai’i environmental nontuberculous mycobacteria reveals unexpected co-isolation with methylobacteria
Authors: Hendrix Jo , Epperson L. Elaine , Tong Eric I. , Chan Yvonne L. , Hasan Nabeeh A. , Dawrs Stephanie N. , Norton Grant J. , Virdi Ravleen , Crooks James L. , Chan Edward D. , Honda Jennifer R. , Strong Michael
Published: September 2023

Nontuberculous mycobacteria (NTM) are ubiquitous environmental opportunistic pathogens that can cause chronic lung disease. Within the United States, Hawai’i has the highest incidence of NTM lung disease, though the precise reasons are yet to be fully elucidated. One possibility is the high prevalence of NTM in the Hawai’i environment acting as a potential reservoir for opportunistic NTM infections. Through our previous initiatives to collect and characterize NTM in Hawai’i, community scientists of Hawai’i have collected thousands of environmental samples for sequencing. Here, these community scientists were invited for the first time into a high school lab in O’ahu for a genomic sequencing workshop, where participants sequenced four of the collected isolate genomic samples using the Oxford Nanopore Technologies MinION sequencer. Participants generated high quality long read data that when combined with short read Illumina data yielded complete bacterial genomic assemblies suitable for in-depth analysis. The gene annotation analysis identified a suite of genes that might help NTM thrive in the Hawai’i environment. Further, we found evidence of co-occurring methylobacteria, revealed from the sequencing data, suggesting that in some cases methylobacteria and NTM may coexist in the same niche, challenging previously accepted paradigms. The sequencing efforts presented here generated novel insights regarding the potential survival strategies and microbial interactions of NTM in the geographic hot spot of Hawai’i. We highlight the contributions of community scientists and present an activity that can be reimplemented as a workshop or classroom activity by other research groups to engage their local communities.
B-mode ultrasound characteristics of carotid plaques in symptomatic and asymptomatic patients with low-grade stenosis
Authors: Sultan Salahaden R. , Khayat Mohammed , Almutairi Bander , Marzouq Abdulhamid , Albngali Ahmad , Abdeen Rawan , Alahmadi Adnan A.S. , Toonsi Fadi
Published: September 2023

Carotid plaque features assessed using B-mode ultrasound can be useful for the prediction of cerebrovascular symptoms. Therefore, the aim of this retrospective study was to determine the ability of ultrasound B-mode imaging to differentiate between carotid plaques causing less than 50% stenosis in symptomatic and asymptomatic patients. A dataset of 1,593 patients with carotid disease who underwent carotid ultrasound between 2016 and 2021 was evaluated retrospectively between January and April of 2022. A total of 107 carotid plaques from 35 symptomatic and 52 asymptomatic patients causing low-grade stenosis on B-mode images were included in the analysis. Chi-square, independent t-test and Mann-Whitney U test were used to compare the variables. There was a significant association between hypertension and the presence of cerebrovascular symptoms (p = 0.01). Predominantly hypoechoic and hyperechoic carotid plaque were significantly associated with the presence and absence of cerebrovascular symptoms, respectively (predominantly hypoechoic: p = 0.01; predominantly hyperechoic: p = 0.02). Surface irregularity was significantly associated with the presence of cerebrovascular symptoms (p = 0.02). There is was a significant difference in the carotid plaque length and area between the symptomatic and asymptomatic patients (plaque length: symptomatic median 9 mm, interquartile range [IQR] 6 mm; asymptomatic median 6 mm, IQR 4.5 mm, p = 0.01; plaque area: symptomatic median 24 mm, IQR 30 mm; asymptomatic median 14 mm, IQR 17 mm, p = 0.01); however, this difference was not significant for plaque thickness (p = 0.55), or common carotid artery intima-media thickness (p = 0.7). Our findings indicate that hypertension patients with predominantly hypoechoic carotid plaques and plaques with an irregular surface are associated with the presence of cerebrovascular symptoms. In addition, the carotid plaques in symptomatic patients were longer and larger compared to asymptomatic patients.
Novel mechanistic insights underlying fungal allergic inflammation
Authors: Zheng Yufan , Dang Eric V.
Published: September 2023

The worldwide prevalence of asthma and allergic disorders (allergic rhinitis, atopic dermatitis, food allergy) has been steadily rising in recent decades. It is now estimated that up to 20% of the global population is afflicted by an allergic disease, with increasing incidence rates in both high- and low-income countries. The World Allergy Organization estimates that the total economic burden of asthma and allergic rhinitis alone is approximately $21 billion per year. While allergic stimuli are a complex and heterogenous class of inputs including parasites, pollens, food antigens, drugs, and metals, it has become clear that fungi are major drivers of allergic disease, with estimates that fungal sensitization occurs in 20–30% of atopic individuals and up to 80% of asthma patients. Fungi are eukaryotic microorganisms that can be found throughout the world in high abundance in both indoor and outdoor environments. Understanding how and why fungi act as triggers of allergic type 2 inflammation will be crucial for combating this important health problem. In recent years, there have been significant advances in our understanding of fungi-induced type 2 immunity, however there is still much we don’t understand, including why fungi have a tendency to induce allergic reactions in the first place. Here, we will discuss how fungi trigger type 2 immune responses and posit why this response has been evolutionarily selected for induction during fungal encounter.
Distinct disease features of acute and persistent genotype 3 hepatitis E virus infection in immunocompetent and immunosuppressed Mongolian gerbils
Authors: Subramaniam Sakthivel , Fares-Gusmao Rafaelle , Sato Shinya , Cullen John M. , Takeda Kazuyo , Farci Patrizia , McGivern David R.
Published: September 2023

Hepatitis E virus (HEV) causes self-limited acute hepatitis in immunocompetent individuals and can establish chronic infection in solid organ transplant recipients taking immunosuppressive drugs. A well characterized small animal model is needed to understand HEV pathogenesis. In this study, we established a robust model to study acute and persistent HEV infection using Mongolian gerbils (Meriones unguiculatus) with or without immunosuppression. Gerbils were implanted subcutaneously with continuous release tacrolimus pellet to induce immunosuppression. Gerbils with or without tacrolimus treatment were inoculated with HEV intraperitoneally. Viremia, fecal virus shedding, serum antibody and ALT levels, liver histopathological lesions, hepatocyte apoptosis, and liver macrophage distribution were assessed. Mild to moderate self-limited hepatitis and IgM and IgG antibody responses against HEV ORF2 were observed in immunocompetent gerbils. Levels of HEV-specific IgM responses were higher and lasted longer in immunocompetent gerbils with higher peak viremia. Persistent viremia and fecal virus shedding with either weak, or absent HEV antibody levels were seen in immunosuppressed gerbils. Following HEV infection, serum ALT levels were increased, with lower and delayed peaks observed in immunosuppressed compared to immunocompetent gerbils. In immunocompetent gerbils, foci of apoptotic hepatocytes were detected that were distributed with inflammatory infiltrates containing CD68+ macrophages. However, these foci were absent in immunosuppressed gerbils. The immunosuppressed gerbils showed no inflammation with no increase in CD68+ macrophages despite high virus replication in liver. Our findings suggest adaptive immune responses are necessary for inducing hepatocyte apoptosis, CD68+ macrophage recruitment, and inflammatory cell infiltration in response to HEV infection. Our studies show that Mongolian gerbils provide a promising model to study pathogenesis during acute and persistent HEV infection.
All grown up at the most magical place on earth: Refracting the Disney adult
Authors: Apollonio Bailey
Published: September 2023

This article seeks to define and analyse the emergence of the term ‘Disney adult’, a pejorative term used by critics to describe adult fans of the Walt Disney Company. In reading the Disney adult as a kitsch-man, I draw attention to how critics play a role in the ultimate dismissal of a fandom that is attributed with excess sentimentality, feminized consumption and ornamentation, and aesthetic deviance. Additionally, I demonstrate how both mid-twentieth-century kitsch scholars and contemporary popular culture critics conflate aesthetic taste with the personal ethics of fans. In doing so, I demonstrate the politics of consumption and how discrimination can operate within fandoms not only based on gender, but also age.
Motiváció és identitás az angol mint idegen nyev tanulásában angol-magyar két tanítási nyelvű általános iskolai tanulók körében
Authors: Bakti Mária
Published: September 2023

Tanulmányunk célja, hogy áttekintse az angolt mint idegen nyelvet tanuló diákok motivációjához és identitásához kapcsolódó kutatásokat, majd röviden összefoglalja két korábbi, a hazai angol-magyar két tanítási nyelvű oktatás és az identitás témájához kapcsolódó vizsgálatunk eredményeit.
A felnőttoktatás és -képzés fejlesztésének kihívásai, avagy hogyan segít a múlt a jövő megértésében
Authors: Németh Balázs
Published: September 2023

Immáron lassan két esztendő telt el azóta, hogy az EU Miniszteri Tanácsa elfogadta 2021 végén az Új Európai Felnőtt-tanulási Akciótervet, mely kijelölte azokat az irányokat, melyek révén lehetőség nyílik a tagországokban érdemben hozzájárulni a felnőtt tanulók számának és tanulási teljesítményének növeléséhez. Ugyanakkor a felnőttek tanulásának támogatásához már rendelkezésre áll három konkrét eszköz, az egyéni tanulási számla (ILA – Individual Learning Account), a mikrotanúsítványok (MC – Microcredentials) és az Europass, mint megújított uniós önéletrajzi eszköz. Az ún. Skills Agenda, vagy magyarosan a Készség és Képesség Napirend a korábbi két évtizedben már kipróbált, vagy tagállami szinten bevált gyakorlatokhoz köthető eszközök átfogó alkalmazását rejti, zömmel foglalkoztathatósági szempontok, egyúttal a társadalmi kohéziót erősítő megfontolások alapján. Érdemes visszatekintenünk a múltba, hogy mikor is jelent meg a nemzeti felnőttoktatási gondolkodásban az a jelenség, hogy lehetőleg minden felnőtt polgár számára egységesen nyújtsanak oktatást és képzést a munkához, valamint a hatékony és eredményes közösségi részvételhez, elkötelezett felelősségvállaláshoz szükséges készségek megszerzése és fejlesztése érdekében.
A Közösségszervezés BA gyakorlati kurzusainak fejlesztése az SZTE JGYPK-n
Authors: Sütő Erika
Published: September 2023

Tanulmányomban a Közösségszervező BA képzés szakmai gyakorlatainak fejlesztési folyamatát mutatom be. Az SZTE JGYPK SZFTI Művelődéstudományi Tanszékén 2018-ban indult az első közösségszervező évfolyam. A tanszéki és kari hagyományokból adódóan a kulturális és ifjúsági közösségszervező szakiránynak már voltak előzményei, s ezzel együtt szakmai partnerei a 160 órás külső gyakorlat megvalósításához. A humánfejlesztő szakirány azonban új volt, fel kellett kutatni a lehetséges partnereket, illetve szükség mutatkozott a gyakorlat informatív leírására. 2022-ben lettem a felelőse a humánfejlesztő szakirány 160 órás gyakorlatának, s ezzel együtt egységes keretben kidolgoztam a szegedi közösségszervező képzés szakmai gyakorlatainak tanulási eredmény alapú leírását. A képzés gyakorlatainak megújítását támogatta a tanszékvezető, Dr. habil. Újvári Edit.
Festőnők (ön)arcképei a 16–17. századi Itáliából
Authors: Vígh Éva
Published: September 2023

Az esszé célkitűzése, hogy három festőnő, Sofonisba Anguissola, Lavinia Fontana, Artemisia Gentileschi (ön)arcképei segítségével vázoljam fel a reneszánsz és barokk kori nők érvényesülési és önkifejezési módjait a festészetben. A művelődéstörténeti vizsgálódások lehetséges útjai meglehetősen összetettek, így mozaikszerűen felidézett művészet-, irodalom-, társadalom-, és mentalitástörténeti utalásokkal kívántam az összefüggésekre rávilágítani.
„Ezt ő jól megérti majd!” – Női szerepek Mozart zenéjében
Authors: Illés Mária
Published: September 2023

Mozart művészetének saját korában legnagyobb hatású, és talán ma is legtöbbeket elérő műfaja az opera. Ez az a műfaj, amellyel Mozart pályája teljes ideje alatt foglalkozott, és később is csak az operai drámaiságra asszociáló versenymű műfaj zárkózott föl mellé jelentőségben a pusztán hangszeres zenei műfajok közül. Az operában a zene megsokszorozza a szöveg tartalmának hatását, érzetté teszi a szereplők személyiség-struktúráját, karakterét, Mozart pedig soha nem látott mértékben forrasztja össze e drámai erőt a szépség, harmonikusság eszméjével. Legnagyobb operáinak feledhetetlen nőalakjai részesülhetnek a bécsi klasszikus stílus megismételhetetlen rendezettségének keretei között megnyilvánuló szellemi, lelki szabadságban, nőiességüket megélve teljesednek ki, akarnak és tudnak is társsá válni. Az ő zenei világuk ad mintát a Mozart-operák egyes férfi szereplőinek is, szabadság, kreativitás tekintetében.
Találkozás a szimbólumokkal – segítő jelenlétük a mindennapokban
Authors: Hevesi Tímea Mária
Published: September 2023

Gondolkodásunkra, döntéseink meghozatalára sok esetben – kiszámíthatatlan módon – hatással van a tudatalattink is. A tudatalattink egy rejtettebb, mélyebb szint, mely a jelenségek összefüggéseit is tartalmazza. A szimbólumok egyrészről többrétegű jelentéstartalmukból adódóan kapcsolódnak a tudatalattihoz, másrészről megjelennek a mindennapjaink valóságában, így a szimbólumok hidat képeznek a tudatalatti és a látható valóság között. Tanulmányunkban olyan szimbólumokat vizsgálunk, melyekkel gyakran találkozunk a mindennapjainkban. Elemezzük azon jelentéstartalmaikat, melyeknek a tudatosításával a szimbólumok „üzeneteit” kognitív szintre hozva, könnyebben értelmezhetővé válhat a jelentésük. Ezáltal a szimbólumok elgondolkodtató, többrétegű jelentéstartalma a mindennapjaink történéseihez kapcsolódva lehetőséget ad arra, hogy ezen történéseket mélyebben, összefüggéseikben is jobban megérthessük.
Five-year Efficacy and Safety of TiNO-Coated Stents Versus Drug-Eluting Stents in Acute Coronary Syndrome. A meta-analysis.
Authors: Daoud Frederic Christopher , Catargi Bogdan , Karjalainen Pasi , Gerbaud Edouard
Published: September 2023

(1) Background: The initial phase of this prospective systematic literature review (SLR) showed that short-term 1-year outcomes with non-drug-eluting titanium-nitride-oxide-coated stents (TiNOS) in acute coronary syndrome (ACS) are non-inferior to drug-eluting stents (DES) in terms of device-oriented composite Major Adverse Cardiac Events (MACE) and safer than DES in terms of recurrent myocardial infarction (MI). This second phase of the SLR assesses long-term 5-year outcomes. (2) Methods: The SLR protocol (PROSPERO CRD4201809062) was conducted per PRISMA guidelines. Prospective, randomized, controlled trials (RCTs) comparing MACE and its components after 5-year follow-up post-PCI with TiNOS vs. DES were searched. Each endpoint's pooled risk ratio (RR) was computed and stratified in RCTs with ACS only vs. RCTs with chronic coronary syndrome (CCS) or ACS. (3) Results: Four RCTs were eligible, comprising 1,772 patients with TiNOS vs. 1,273 with DES. Three RCTs reported outcomes in ACS only (1,630 vs. 1,123 pa-tients). Pooled RRs in the ACS-only RCTs were: MACE 0.82 [0.68, 0.99], MI 0.58 [0.44, 0.78], cardiac death (CD) 0.46 [0.28, 0.76], ischemia-driven target lesion revascularization (TLR) 1.03 [0.79, 1.33], probable or definite stent thrombosis (ST) 0.32 [0.21, 0.59], and total death (TD) 0.84 [0.63, 1.12]. Evidence certainty was high and robust to sensitivity analysis in MACE, MI, and ST, moderate and not robust in CD, TLR, and TD. The clinical validation and generalization would require stratifying the pooled RRs by clinical presentation. (4) Conclusions: TiNOS efficacy appears safer than DES in CD, MI, and ST and is similarly efficacious in TLR, and MACE, with a similar TD rate, in ACS at 5-year follow-up.
Predictors of Relationship Continuity in Families With Incarcerated Fathers
Authors: Gonzalez Henry
Published: September 2023

Paternal incarceration can destabilize families due to the disruption and stress that follow. For mothers, maintaining a relationship with incarcerated fathers from home while raising a child can be incredibly difficult. What keeps a relationship from dissolving after a father is incarcerated
is not well understood. This study used family stress theory to identify the family capabilities and meanings associated with increased odds of relationship continuity among a sample of 116 families with incarcerated fathers. The findings revealed that families stayed intact when mothers reported
a history of paternal incarceration and a positive relationship with the father prior to incarceration. This study shows the value of family meanings over family capabilities in overcoming the risks of relationship dissolution associated with paternal incarceration.
Getting Connected With FCS Connect!
Authors: Sneed Christopher T. , Washburn Lisa , Franck Karen
Published: September 2023

Successful Extension programming relies on strong relationships between campus-based Extension faculty/specialists and the field-based Extension agents they support (Shaklee et al., 2014). Strong connections facilitate bi-directional communication, enabling specialists to understand
the needs of agents and their communities. The COVID-19 pandemic and subsequent county and university office closures could have stymied these campus–county connections. Instead, it cleared a path to virtually strengthen relationships between Extension countybased and university-based
staff through FCS Connect!
Features of achieving compensation of hypothyroisis in pregnant women
Authors: Yakubova E. G.
Published: September 2023

BACKGROUND: Hypofunction of the thyroid gland in women at the pre-pregnancy stage and during pregnancy is associated with a high risk of congenital hypothyroidism in children, as a result of which irreversible changes in the nervous system are formed. Despite the mandatory intake of potassium iodide preparations, pregnant women often develop gestational hypothyroidism, which requires the appointment of levothyroxine. Many women have episodic hypofunction of the thyroid gland before pregnancy, associated with various factors. Diagnosed hypothyroidism requires hormonal correction. The recommended dose of levothyroxine calculated by the patient’s weight is not always adequate to achieve TSH targets. In addition, there are pharmacological factors. Levothyroxine sodium preparations differ in bioavailability. The stability of drugs is affected by external factors and the composition of fillers from different manufacturers of drugs.AIM: To assess the dependence of TSH reduction on the method of taking levothyroxine in a population of pregnant women.MATERIALS AND METHODS: Statistical analysis and prospective study was carried out from 2019 to 2021. On the basis of the «Perinatal Center», Tyumen, women’s consultative and diagnostic department. Pregnant women with diagnosed primary subclinical and manifest hypothyroidism in the first trimester of pregnancy (n=76) were selected for cohort observation. All pregnant women were prescribed L-thyroxine Berlin-hemi. Other levothyroxine preparations were not used in order to exclude distortion of the results of the study.

RESULTS: Pregnant women with hypothyroidism were divided into two groups according to the method of taking L-thyroxine: oral (n=54) and sublingual (n=22). A month later, TSH normalization was observed in 41 pregnant women in the oral group (76%) and in 22 pregnant women in the sublingual group (100%). Women who did not achieve hypothyroidism compensation were recommended sublingual administration without increasing the dose of L-thyroxine, provided that TSH was no higher than 4.0 mcME / ml. A TSH study a month later showed that all pregnant women achieved compensation. CONCLUSION: Based on the conducted research, it is shown that the more rational administration of levothyroxine sodium preparations is sublingual, since there is a slightly alkaline reaction in the oral cavity, which does not have a destructive effect, like gastric juice.
Thyroid functional autonomy — sclerotherapy and radioactive iodine therapy: case report
Authors: Buyvalenko U. V. , Sheremeta M. S. , Kim I. V. , Trukhin A. A. , Korchagina M. O. , Sviridenko N. Yu.
Published: September 2023

Thyroid functional autonomy (TFA) is the most frequent reasons of subclinical or manifest thyrotoxicosis. Diagnosis of the causes of thyrotoxicosis (destruction or increased functional activity of the thyroid tissue in nodular and diffuse thyroid pathology) is a key point in determining the management of patients with this pathology. Scintigraphy is the method of choice in differential diagnosis of the causes of thyrotoxicosis assessing the functional state of the thyroid gland. Thyroid scintigraphy can be performed using 99mTc-pertechnetate. After normalization of the level of thyroid hormones is confirmed, radical treatment is recommended. It could be surgery or radioactive iodine therapy (RAI). In some cases, especially in the elderly women, TFA is combined with thyroid nodules (TN), which can cause pressure symptoms, cosmetic complaints, and thyroid dysfunction. Minimally invasive treatments, such as percutaneous ethanol injection (PEI) sclerotherapy, has been proposed, especially for pressure symptoms and cosmetic complaints, as an alternative to surgery. The presented clinical case will demonstrate the possibility of use sclerotherapy and RAI for the successful treatment of TFA with TN.
Examining the influence of Entrepreneurship Education on Entrepreneurial Intention: A gender-focused analysis of intentions among undergraduate students
Authors: Ode Egena , Shitu Sidikat , Adegbe Ochanya Blessing
Published: September 2023

Background: In recent years, there has been a growing interest in understanding the impact of entrepreneurship education (EE) on entrepreneurial intentions (EI) among undergraduate students, as EI is a critical precursor to actual entrepreneurial behaviour. However, there is limited research that specifically explores the influence of EE on EI with a focus on gender differences, especially in developing countries.Purpose: This study investigates the influence of EE on undergraduate students’ EI, with a focus on the cognitive, behavioural, and affective components of EE. Additionally, the study explores how perceived competence of entrepreneurship lecturers, adequacy of facilities and equipment, and perceived adequacy of instructional materials and curriculum content influence students' EI. Furthermore, the study examines whether the effect of these factors varies among male and female undergraduate students. Methodology: The researchers collected data from undergraduate students over a three-year period via a self-reported online questionnaire. Hierarchical regression analysis was used for data analysis using SPSS version 24.Findings: The findings reveal a positive relationship between students’ EE and EI. The results further indicate that while cognitive attitudes do not influence EI, behavioral and affective attitudes do. Moreover, the study highlights that the influence of EE on EI differs among male and female students. Implications and conclusion: This study provides valuable insights into the teaching and delivery of EE in higher education institutions (HEIs), emphasizing the importance of instructional methods, materials, facilities, and equipment in shaping EI in developing countries.
Graphical complexes of groups
Authors: Prytuła Tomasz
Published: September 2023

We introduce graphical complexes of groups, which can be thought of as a generalisation of Coxeter systems with 1-dimensional nerves.
We show that these complexes are strictly developable, and we equip the resulting Basic Construction with three structures of non-positive curvature: piecewise linear

CAT
⁢

(
0
)

\mathrm{CAT}(0)

,

C
⁢

(
6
)

C(6)

graphical small cancellation, and a systolic one.
We then use these structures to establish various properties of the fundamental groups of these complexes, such as biautomaticity and the Tits Alternative.
We isolate an easily checkable condition implying hyperbolicity of the fundamental groups, and we construct some non-hyperbolic examples.
We also briefly discuss a parallel theory of

C
⁢

(
4
)

C(4)

-

T
⁢

(
4
)

T(4)

graphical complexes of groups and outline their basic properties.
Cognitive empathy of osteopathic students: a longitudinal study with data comparisons to the Project in Osteopathic Medical Education and Empathy (POMEE)
Authors: Newton Bruce W. , Vaskalis Zachary T.
Published: September 2023

Context

Establishing an empathic bond of trust with patients is a characteristic that physicians need, because patients feel that physicians are more caring if they sense that they are empathetic. Former cross-sectional studies have shown an erosion of cognitive empathy as medical students progress through their education.

Objectives

This study aims to measure the changes in student cognitive empathy as they progress through their undergraduate osteopathic medical education. Cognitive empathy scores are compared to the nationwide norms established by the Project in Osteopathic Medical Education and Empathy (POMEE) study by Mohammadreza Hojat, PhD, and colleagues.

Methods

During orientation to medical school, and at the beginning of each subsequent academic year, and just before graduation, the graduating classes of 2017–2019 participated in this longitudinal study by filling out the Jefferson Scale of Empathy-Student Version (JSE-S). A total of 345/459 Osteopathic Medical Student (OMS) I-IV students (75.2 % of the graduates) filled out the forms for all five time points. Desired specialty choice and sex were also collected. Specialty choice was divided into Core and Non-Core groups. Core specialties are “people-oriented” and have a large amount of patient contact and continuity of care, while Non-Core specialties are “technical- or procedure-oriented” and have little or no patient contact and/or continuity of care.

Results

Men selecting Non-Core specialties had significant drops in JSE-S scores (p=0.001); whereas men who selected the Core specialties did not have a significant decrease. For women, there was no significant drop in JSE-S scores for those selecting either Core or Non-Core specialties. When compared to POMEE norm data, none of the Campbell University School of Medicine students had JSE-S scores that were above the 50th percentile.

Conclusions

Students selecting Core specialties do a better job of maintaining their cognitive empathy, which aids their ability to establish an empathic bond of trust with patients, when compared to students who desire Non-Core specialties. JSE-S scores not above the POMEE 50th percentile is concerning and indicate either a curricular change to better enhance empathic communication skills and/or better applicant selection.
Approximate controllability for a stochastic elastic system with structural damping and infinite delay
Authors: Peng Jiankui , Gao Xiang , Su Yongbing , Kang Xiaodong
Published: September 2023

In this article, we study the existence of mild solutions and the approximate controllability for a class of stochastic elastic systems with structural damping and infinite delay in Hilbert spaces. The estimation of the control function is discussed, where the expression of the control function is constructed by the defined resolvent operator. Under this estimate, the existence of mild solutions for this system is obtained by the Schauder fixed point theorem and the stochastic analysis theory, and sufficient conditions for the approximate controllability are formulated and proved by using the so-called resolvent operator type condition. Finally, an example is given to illustrate the applicability of our conclusion.
A novel hybrid Fick’s law algorithm-quasi oppositional–based learning algorithm for solving constrained mechanical design problems
Authors: Mehta Pranav , Yildiz Betül Sultan , Sait Sadiq M. , Yildiz Ali Riza
Published: September 2023

In this article, a recently developed physics-based Fick’s law optimization algorithm is utilized to solve engineering optimization challenges. The performance of the algorithm is further improved by incorporating quasi-oppositional–based techniques at the programming level. The modified algorithm was applied to optimize the rolling element bearing system, robot gripper, planetary gear system, and hydrostatic thrust bearing, along with shape optimization of the vehicle bracket system. Accordingly, the algorithm realizes promising statistical results compared to the rest of the well-known algorithms. Furthermore, the required number of iterations was comparatively less required to attain the global optimum solution. Moreover, deviations in the results were the least even when other optimizers provided better or more competitive results. This being said that this optimization algorithm can be adopted for a critical and wide range of industrial and real-world challenges optimization.
The invention of Volta’s Pile and its diffusion in Europe at war in the year 1800
Authors: Fabbrizzi Luigi
Published: September 2023

Alessandro Volta built his pile in the winter of 1799 in his country house with no lab and no technical staff because, due to the war against Napoleon, the Austrians had closed the University of Pavia and fired the professors. Volta sent the article on the pile to the Royal Society in March 1800, and through the long process of publication in the journal Philosophical Transactions (September 1800), the news spread through the London scientific community. The physician Anthony Carlisle and the chemist and editor William Nicholson were the first to build a battery and used it to decompose water. The great news that electricity could be generated by a simple and easily constructed device was also printed in the daily newspapers, which helped to spread the word throughout Europe and inspired scientists and practitioners to build their own pile and carry out the electrical decomposition of various electrolytes, thus creating the basis for the new discipline of electrochemistry.
Inspection of Couette and pressure-driven Poiseuille entropy-optimized dissipated flow in a suction/injection horizontal channel: Analytical solutions
Authors: Song Min , Sukumar M. , Raju C. S. K. , Varma S. V. K. , Ijaz Khan M. , Awwad Fuad A. , Ismail Emad A. A.
Published: September 2023

The main aim of this study is to analyse the electrically conductive flow of compressible liquids by two infinitely permeable surfaces. The distance between the two surfaces is

h

h

. Thermal relation consists of viscous dissipation. The entropy features along with magnetic force and dissipation are taken into account. The x-axis extends in the flow path along the bottom stationary plate, whereas the y-axis is orthogonal to the surfaces. The channel plates are subjected to a consistent transverse magnetic field that is implemented perpendicularly. Herein, two scenarios are investigated: the first is the Couette flow, and in the second scenario, both porous surfaces are parallel and fixed at a distance of 2h, and the motion is a Poiseuille flow controlled by pressure. The flow across the

x

x

-axis is supposed to be generated and dependent on

y

y

exclusively. The governed system is solved using analytical solutions. It is found that the entropy formation is higher near the cloud porous plate in comparison to the hot porous plate and the increasing values of the suction/injection parameter increase the fluid temperature. The increase in the magnetic field parameter decreases the momentum boundary layer thickness. The Brinkman number improves the thermal boundary thickness. The magnetic field parameter, suction/injection, and the Brinkman number accelerate the entropy formation in both cases.
Kinetic studies of catalytic and antioxidant activities of biosynthesized franklinite (ZnFe2O4) nanoparticles using Coriandrum sativum leaf extract
Authors: Younas Umer , Fatima Zumer , Saleem Aimon , Zaki Zaki I. , Ali Faisal , Pervaiz Muhammad , Ashraf Adnan , Fallatah Ahmed M. , Iqbal Munawar , Ibrahim Mohamed M.
Published: September 2023

Industrialization and urbanization have now become major factors in damaging different segments of the environment. Synthesis of novel nanomaterials for the removal of dyes and free radicals from aqueous medium has become a challenge for the researchers. The present work describes formation of novel-franklinite (ZnFe2O4) nanoparticles (FNPs) which have been synthesized adopting economical route of green method using extracts of fresh and dried leaves of Coriandrum sativum. The fabricated NPs were characterized employing state of the art analytical techniques including UV-visible, FTIR, SEM and XRD. The nanocatalyst exhibited excellent catalytic properties for the degradation of eosin yellow up to 86 % in 22 min and 90 % in 16 min using zinc-ferrite NPs synthesized using dried and fresh leaves respectively. Antioxidant activity of ZnFe2O4 in terms of DPPH and ABTS free radicals scavenging was also determined. Nanoparticles synthesized using fresh leaves exhibited better antiradical potential in comparison to NPs synthesized dried leaves. Therefore, synthesis of FNPs with active features can be achieved using extract of fresh plant. Franklinite NPs can be used as promising photocatalyst for the degradation of organic pollutants and scavenging of free radicals.
Consumo y principales fuentes alimentarias de polifenoles en egresados de la Licenciatura en Nutrición de una universidad pública del sureste de México
Authors: Marín-Canul Jesús Enrique , Mut-Martín Mirza , Espinoza-García Astrid Selene , Pérez-Izquierdo Odette , Ávila-Escalante María Luisa , Góngora-Alfaro José Luis , Aranda Gonzalez Irma Isela
Published: September 2023

Estudios sobre el consumo de polifenoles (PF) en mexicanos, incluyendo profesionales de la salud, son escasos. El objetivo fue determinar el consumo total y subtipo de PF en egresados de la Licenciatura en Nutrición de una universidad pública del sureste de México. Se utilizó un recordatorio de 24 horas (RD-24) como instrumento de recolección de datos, así como la base de datos Phenol-Explorer y la del Departamento de Agricultura de los Estados Unidos (USDA). Adicionalmente, se identificaron alimentos con mayor contenido de PF y alimentos ausentes en las bases de datos. El consumo de PF fue variable (1216 mg/día promedio), mayor a lo reportado a nivel nacional y a nivel estatal, e incluso mayor a lo reportado en algunos países europeos, superando la cantidad asociada a menor riesgo cardiovascular (1170 mg/día). El consumo de flavonoides y ácidos fenólicos fue bajo, mientras que el consumo de lignanos y estilbenos fue infrecuente. Algunos alimentos locales están ausentes en las bases de datos.
Multi-faceted analyses of Poland's Bronze and Early Iron Age hoards
Authors: Maciejewski Marcin
Published: September 2023

Bronze and Early Iron Age hoards in Poland are the focus of a multi-faceted study combining archival research with laboratory analyses and landscape studies. The diverse dataset is expected to reveal new insights into the phenomenon of metal deposition.