bluuebunny/crossref_metadata_2025 huggingface dataset:
Low Sintering Temperature Effect on Crystal Structure and Dielectric Properties of Lead-Free Piezoelectric Bi0.5Na0.5TiO3-NaFeTiO4
Authors: Betancourt-Cantera Luis G. , Reséndiz-Trejo Yaneli , Sánchez-De Jesús Félix , Cortés Escobedo Claudia A. , Bolarín-Miró Ana M.
Published: October 2024

Bi0.5Na0.5TiO3 (BNT) emerges as a promising ferroelectric and piezoelectric lead-free candidate to substitute the contaminant Pb[TixZr1−x]O3 (PZT). However, to obtain optimal ferroelectric and piezoelectric properties, BNT must be sintered at high temperatures. In this work, the reduction of sintering temperature by using iron added to BNT is demonstrated, without significant detriment to the dielectric properties. BNT-xFe with iron from x = 0 to 0.1 mol (∆x = 0.025) were synthesized using high-energy ball milling followed by sintering at 900 °C. XRD analysis confirmed the presence of rhombohedral BNT together with a new phase of NaFeTiO4 (NFT), which was also corroborated using optical and electronic microscopy. The relative permittivity, in the range of 400 to 500 across all the frequencies, demonstrated the stabilization effect of the iron in BNT. Additionally, the presence of iron elevates the transition from ferroelectric to paraelectric structure, increasing it from 330 °C in the iron-free sample to 370 °C in the sample with the maximum iron concentration (0.1 mol). The dielectric losses maintain constant values lower than 0.1. In this case, low dielectric loss values are ideal for ferroelectric and piezoelectric materials, as they ensure minimal energy dissipation. Likewise, the electrical conductivity maintains a semiconductor behavior across a range of 50 Hz to 1 × 106 Hz, indicating the potential of these materials for applications at different frequencies. Additionally, the piezoelectric constant (d33) values decrease slightly when low concentrations of iron are added, maintaining values between 30 and 48 pC/N for BNT-0.025Fe and BNT-0.05Fe, respectively.
Adsorption Performance of Fe–Mn Polymer Nanocomposites for Arsenic Removal: Insights from Kinetic and Isotherm Models
Authors: Nikić Jasmina , Watson Malcolm , Jokić Govedarica Jovana , Vujić Maja , Pešić Jovana , Rončević Srđan , Agbaba Jasmina
Published: October 2024

Global concern over arsenic contamination in drinking water necessitates innovative and sustainable remediation technologies. This study evaluates the adsorption performance of Fe–Mn binary oxide (FMBO) nanocomposites developed by coating polyethylene (PE) and polyethylene terephthalate (PET) with FMBO for the removal of As(III) and As(V) from water. Adsorption kinetics were rapid, with equilibrium achieved within 1–4 h depending on the material and pH. PET-FMBO and FMBO exhibited faster rates and higher arsenic removal (up to 96%) than PE-FMBO. Maximum As(III) adsorption capacities ranged from 4.76 to 5.75 mg/g for PE-FMBO, 7.2 to 12.0 mg/g for PET-FMBO, and up to 20.8 mg/g for FMBO, while capacities for As(V) ranged from 5.20 to 5.60 mg/g, 7.63 to 18.4 mg/g, and up to 46.2 mg/g, respectively. The results of the Dubinin–Radushkevich isotherm model, with free energy (Ea) values exceeding 16 kJ/mol, suggest chemisorption is the dominant mechanism, which is supported by the kinetics data. Given the effective removal of As(III), chemisorption likely proceeds through ligand exchange during the Mn oxide-mediated oxidation of As(III) and complexation with hydroxyl groups on the nanocomposite. These findings highlight the strong potential of Fe–Mn polymer nanocomposites, particularly PET-FMBO, for efficient arsenic removal during practical water treatment applications.
Analysis of Complications of a Neglected Disease: 13 Years of Experience with Liver Hydatid Cysts in a High-Volume Hospital
Authors: Azizoğlu Mustafa , Aydogdu Bahattin , Kamci Tahsin Onat , Arslan Serkan , Basuguy Erol , Bilici Salim , Okur Mehmet Hanifi
Published: October 2024

Background and Objectives: The aim of this study was to evaluate the clinical presentation, treatment outcomes, and complications associated with hepatic hydatid cysts in a pediatric population. Materials and Methods: This retrospective study analyzed 214 pediatric patients with liver hydatid cysts, focusing on clinical presentation, treatment outcomes, and associated complications. Patients were classified based on treatment modality, including non-operative management with albendazole, PAIR, and surgical intervention. This study compared cyst characteristics, recurrence rates, and complications such as cysto-biliary fistulas. Results: Among the patients, 68% (n = 145) had a single cyst and 86% (n = 184) were found to have isolated liver cysts. No significant statistical difference was observed between Group 1 and Group 2 in terms of age, gender, and basic laboratory values and general characteristics of the cysts, such as the lobe where the cyst was located, involvement of multiple organs, number of cysts, the state of cyst rupture, and recurrence; no statistically significant difference was found between the groups (p > 0.05 for each comparison). Cyst rupture incidence was 6%, and the average incidence of recurrence was 2%, with a surgical recurrence incidence of 3%. A total of 37 patients had a laparotomy, while 7 had laparoscopic surgery. In total, capitonnage was performed in 68 patients, omentopexy in 4, and cystostomy in 6. Consequently, among the treated patients (PAIR + surgery), the incidence of cysto-biliary fistula was 11%, anaphylaxis was 2%, surgical recurrence was 3%, and the incidence of reoperation (Clavien–Dindo ≥ 3) was 6%. The average follow-up period was 72 months, during which no mortality was observed. Conclusions: We identified key clinical outcomes related to both non-surgical treatments (cyst rupture and recurrence) and surgical groups (cysto-biliary fistulas, anaphylaxis, the need for reoperation, rupture, and recurrence).
Association of Age at Menarche with General and Abdominal Obesity in Young Women
Authors: Rakic Rada , Pavlica Tatjana , Havrljenko Jelena , Bjelanovic Jelena
Published: October 2024

Background and Objectives: Age at menarche is related to various biological and socioeconomic factors in childhood. The aim of the study was to examine the association of age at menarche with general and abdominal obesity in young women. Materials and Methods: A transversal anthropometric survey was conducted with 102 females from 21 to 25 years of age. The surveyed traits included height, weight, waist circumference (WC) and hip circumference (HC). General obesity was assessed using the body mass index (BMI) and abdominal obesity by WC, waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR). A retrospective method was used for collecting age at menarche data. Results: The average age at menarche is 12.80 years. Early menarcheal age (<12 years) is detected in 25.5% of young females, while late onset of menarche (>14 years) is recorded for 20.6% of subjects. Early menarche age subjects exhibit significantly higher BMI, WC and WHtR in comparison with their late menarche age peers. There is a significant negative correlation between BMI, WC and WHtR values and menarcheal age. Late age at menarche is associated with higher probability of underweight status (BMI < 18.5 and/or WHtR < 0.4). Conclusions: Age at menarche has a negative correlation with general and abdominal obesity. Young women with early age at menarche show statistically higher values of BMI, WC and WHtR, while those with late menarcheal age show greater susceptibility to becoming underweight.
Holistic Research for Lithium-Ion Battery Recycling as Basis for a Sustainable Industrial Business
Authors: Friedrich Bernd , Dittmer Dominic
Published: October 2024

An understanding of the global climate and technological progress are driving e-mobility forward worldwide [...]
Applying Alkali Activator and Hydrophobic Agents in Clay-Based Mortars for Enhanced Properties
Authors: Karozou Aspasia , Kesikidou Fotini , Pavlidou Eleni , Stefanidou Maria
Published: October 2024

Clay-based mortars are susceptible to water intake and exhibit low mechanical strength, presenting challenges in their application within the construction sector. This research addresses these vulnerabilities by investigating the combination of alkali activators with waterproofing agents, specifically a nano-clay and an acrylic emulsion, to enhance the properties of clay mortars. Alkali-activated materials are known for their superior mechanical properties and sustainable potential, especially when derived from low-cost by-products. Recent studies have focused on alkali activation using clays and soils as precursors to improve their physical and mechanical properties while increasing durability. However, the high absorbency of these mortars remains a concern, as it can lead to matrix degradation. Therefore, to address these problems, this research studied the combination of a highly alkaline activator (potassium metasilicate) with hydrophobic agents, such as a nano-clay and an acrylic emulsion, using two different clayey soils. The results indicated that potassium metasilicate (PO) enhanced the mechanical properties and stability for both aluminosilicate systems, while nano-clay (PONC) significantly reduced the capillary absorption through time, especially in A2 systems. The addition of acrylic emulsion (POD) proved highly effective in both systems, significantly improving durability. By integrating these agents, the mortar systems were protected against water intake, while durable construction materials were formed.
Pyrite Depression by Sodium Metabisulfite in Freshwater and Seawater with Copper Activation
Authors: Castellón César I. , Toledo Pedro , Rojas Francisco , Sepúlveda Felipe D. , Jeldres Ricardo I.
Published: October 2024

Pyrite has natural floatability and thus readily enters valuable mineral flotation concentrates, diluting their quality and decreasing their economic value. Its separation is challenging, depending on process conditions, the presence of activating ions, and water quality, particularly in regions where seawater is used. This study examines the effect of various doses of sodium metabisulfite (SMBS) on pyrite depression in freshwater and seawater under weakly alkaline conditions and with different copper ion concentrations. Without the addition of activators or depressants, pyrite recovery is 40% in freshwater and 60% in seawater, whereas with 10 ppm of SMBS, recoveries drop to 28% and 38%, respectively. The addition of 10 ppm Cu2+ increases recovery by 10% in freshwater and by 20% in seawater. In the presence of 75 ppm of PAX, maximum recovery reached 50% in freshwater and 80% in seawater. These results suggest that cationic bridges formed by seawater ions, combined with CaOH+ activation, play a critical role in pyrite activation, even in the presence of depressants.
Optimization of the Cold Water Extraction Method for High-Value Bioactive Compounds from Chamomile (Matricaria chamomilla L.) Flower Heads Through Chemometrics
Authors: Foschi Martina , Marsili Lorenzo , Luciani Ilaria , Gornati Giulia , Scappaticci Claudia , Ruggieri Fabrizio , D’Archivio Angelo Antonio , Biancolillo Alessandra
Published: October 2024

This study focused on optimizing a cold water extraction method to obtain bioactive compounds from chamomile (Matricaria chamomilla L.), addressing increasing consumer demand for natural products and nutraceuticals. A full-factorial design was employed to evaluate the effects of temperature, time, and chamomile amount on the polyphenolic profile of extracts. The samples were characterized by HPLC-DAD and UV-Vis coupled with chemometrics; the analysis showed that extraction time negatively affected extract quality, as did the interaction between time and temperature. In addition, a significant positive quadratic effect for temperature and a positive coefficient for chamomile amount was found. ASCA was used to assess the UV-Vis profile, offering an alternative untargeted method for understanding the variable effects. The optimal extraction conditions (25 °C, 32 min, and 2.5 g of chamomile) produced samples high in hydroxybenzoic and hydroxycinnamic acids and flavanol derivatives. Using A face-centered design, this study also monitored antioxidant activity via a DPPH scavenging assay, confirming that the optimal conditions yielded samples within the range of maximum antioxidant activity in the studied experimental domain.
Advances in Research on the Improvement of Low-Salt Meat Product Through Ultrasound Technology: Quality, Myofibrillar Proteins, and Gelation Properties
Authors: Guo Xiuyun , Xu Shuangyi , Fu Chao , Peng Zengqi
Published: October 2024

The high sodium content in meat products poses health risks to consumers and does not align with modern green and healthy living standards. Current strategies for directly reducing the sodium content in meat products are limited by their negative impact on the sensory or quality attributes of the products. In recent years, there has been great interest in applying ultrasound technology to reduce sodium content. This paper discusses the advantages and disadvantages of current mainstream strategies for reducing the sodium content in meat products, as well as the potential mechanisms by which ultrasound-assisted marination improves the quality of low-salt meat products. The main findings indicate that ultrasound, through its cavitation and mechanical effects, facilitates the transition of proteins from stable insoluble aggregates to stable soluble complexes, exposing more hydrophilic groups and, thus, enhancing protein solubility. At the same time, ultrasound promotes a greater number of proteins to participate in the formation of interfacial layers, thereby increasing emulsifying activity. Furthermore, ultrasound treatment promotes the interaction between proteins and water, leading to partial unfolding of protein chains, which allows polar residues to more readily capture water in the gel, thereby improving the water-holding capacity of the gel. These effects will contribute to the formation of high-quality low-salt meat products. However, variations in the frequency, intensity, and duration of ultrasound treatment can lead to differing effects on the quality improvement of low-salt meat products.
Saponin Molecules from Quinoa Residues: Exploring Their Surfactant, Emulsifying, and Detergent Properties
Authors: Bustos Kiara A. García , Muñoz Salvador Sanchez , da Silva Silvio S. , Alarcon Miguel A. D. Flores , dos Santos Júlio C. , Andrade Gilberto J. Colina , Hilares Ruly Terán
Published: October 2024

The indiscriminate use of synthetic surfactants, despite their desirable properties, poses significant environmental risks to ecosystems. This study explores saponins extracted from quinoa (Chenopodium quinoa) residues as a sustainable alternative. Saponin extract (SE) with 42% purity, obtained through hydrodynamic cavitation and membrane technology, was analyzed to determine its techno-functional properties. The critical micelle concentration (CMC) was 1.2 g/L, reducing the surface tension (ST) from 72.0 mN/m to 50.0 mN/m. The effects of temperature (30–90 °C), pH (2–12), and salinity (10,000–150,000 ppm NaCl) on ST and the emulsification index (EI) were assessed using a Box–Behnken design. Optimized conditions yielded an ST of 49.02 mN/m and an EI of 63%. Given these characteristics, SE was evaluated as a detergent across diverse swatches. This study showcases the attributes of quinoa-derived saponins, highlighting their potential for eco-friendly detergent applications.
Opportunities and Challenges of Multi-Ion, Dual-Ion and Single-Ion Intercalation in Phosphate-Based Polyanionic Cathodes for Zinc-Ion Batteries
Authors: Cao Lei , Du Tao , Wang Hao , Cheng Zhen-Yu , Wang Yi-Song , Zhou Li-Feng
Published: October 2024

Abstract: With the continuous development of science and technology, battery storage systems for clean energy have become crucial for global economic transformation. Among various rechargeable batteries, lithium-ion batteries are widely used, but face issues like limited resources, high costs, and safety concerns. In contrast, zinc-ion batteries, as a complement to lithium-ion batteries, are drawing increasing attention. In the exploration of zinc-ion batteries, especially of phosphate-based cathodes, the battery action mechanism has a profound impact on the battery performance. In this paper, we first review the interaction mechanism of multi-ion, dual-ion, and single-ion water zinc batteries. Then, the impact of the above mechanisms on battery performance was discussed. Finally, the application prospects of the effective use of multi-ion, dual-ion, and single-ion intercalation technology in zinc-ion batteries is reviewed, which has significance for guiding the development of rechargeable water zinc-ion batteries in the future.
Targeted PHA Microsphere-Loaded Triple-Drug System with Sustained Drug Release for Synergistic Chemotherapy and Gene Therapy
Authors: Wang Shuo , Zhang Chao , Liu Huandi , Fan Xueyu , Fu Shuangqing , Li Wei , Zhang Honglei
Published: October 2024

The combination of paclitaxel (PTX) with other chemotherapy drugs (e.g., gemcitabine, GEM) or genetic drugs (e.g., siRNA) has been shown to enhance therapeutic efficacy against tumors, reduce individual drug dosages, and prevent drug resistance associated with single-drug treatments. However, the varying solubility of chemotherapy drugs and genetic drugs presents a challenge in co-delivering these agents. In this study, nanoparticles loaded with PTX were prepared using the biodegradable polymer material poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx). These nanoparticles were surface-modified with target proteins (Affibody molecules) and RALA cationic peptides to create core-shell structured microspheres with targeted and cationic functionalization. A three-drug co-delivery system (PTX@PHBHHx-ARP/siRNAGEM) were developed by electrostatically adsorbing siRNA chains containing GEM onto the microsphere surface. The encapsulation efficiency of PTX in the nanodrug was found to be 81.02%, with a drug loading of 5.09%. The chemogene adsorption capacity of siRNAGEM was determined to be 97.3%. Morphological and size characterization of the nanodrug revealed that PTX@PHBHHx-ARP/siRNAGEM is a rough-surfaced microsphere with a particle size of approximately 150 nm. This nanodrug exhibited targeting capabilities toward BT474 cells with HER2 overexpression while showing limited targeting ability toward MCF-7 cells with low HER2 expression. Results from the MTT assay demonstrated that PTX@PHBHHx-ARP/siRNAGEM exhibits high cytotoxicity and excellent combination therapy efficacy compared to physically mixed PTX/GEM/siRNA. Additionally, Western blot analysis confirmed that siRNA-mediated reduction of Bcl-2 expression significantly enhanced cell apoptosis mediated by PTX or GEM in tumor cells, thereby increasing cell sensitivity to PTX and GEM. This study presents a novel targeted nanosystem for the co-delivery of chemotherapy drugs and genetic drugs.
DNA: Novel Crystallization Regulator for Solid Polymer Electrolytes in High-Performance Lithium-Ion Batteries
Authors: Cheng Xiong , Bae Joonho
Published: October 2024

In this work, we designed a novel polyvinylidene fluoride (PVDF)@DNA solid polymer electrolyte, wherein DNA, as a plasticizer-like additive, reduced the crystallinity of the solid polymer electrolyte and improved its ionic conductivity. At the same time, due to its Lewis acid effect, DNA promotes the dissociation of lithium salts when interacting with lithium salt anions and can also fix the anions, creating more free lithium ions in the electrolyte and thus improving its ionic conductivity. However, owing to hydrogen bonding between DNA and PVDF, excess DNA occupies the lone pairs of electrons of the fluorine atoms on the PVDF molecular chains, affecting the conduction of lithium ions and the conductivity of the solid electrolyte. Hence, in this study, we investigated the effects of adding different DNA amounts to solid polymer electrolytes. The results show that 1% DNA addition resulted in the best improvement in the electrochemical performance of the electrolyte, demonstrating a high ionic conductivity of 3.74 × 10−5 S/cm (25 °C). The initial capacity reached 120 mAh/g; moreover, after 500 cycles, the all-solid-state batteries exhibited a capacity retention of approximately 71%, showing an outstanding cycling performance.
Using Femtosecond Laser Light to Investigate the Concentration- and Size-Dependent Nonlinear Optical Properties of Laser-Ablated CuO Quantum Dots
Authors: Ashour Mohamed , Ibrahim Rasha , Abd El-Salam Yasmin , Abdel Samad Fatma , Mahmoud Alaa , Mohamed Tarek
Published: October 2024

In this work, the nonlinear optical (NLO) properties of CuO nanoparticles (CuO NPs) were studied experimentally using the pulsed laser ablation (PLA) technique. A nanosecond Nd: YAG laser was employed as the ablation excitation source to create CuO NPs in distilled water. Various CuO NPs samples were prepared at ablation periods of 20, 30, and 40 min. Utilizing HR-TEM, the structure of the synthesized CuO NPs samples was verified. In addition, a UV–VIS spectrophotometer was used to investigate the linear features of the samples. The Z-scan technique was utilized to explore the NLO properties of CuO NPs samples, including the nonlinear absorption coefficient (β) and nonlinear refractive index (n2). An experimental study on the NLO features was conducted at a variety of excitation wavelengths (750–850 nm), average excitation powers (0.8–1.2 W), and CuO NPs sample concentrations and sizes. The reverse saturable absorption (RSA) behavior of all CuO NPs samples differed with the excitation wavelength and average excitation power. In addition, the CuO NPs samples demonstrated excellent optical limiters at various excitation wavelengths, with limitations dependent on the size and concentration of CuO NPs.
Subacute Effects of Moderate-Intensity Aerobic Exercise in the Fasted State on Cell Metabolism and Signaling in Sedentary Rats
Authors: Ayres Layane Ramos , Vogt Éverton Lopes , Schroeder Helena Trevisan , Russo Mariana Kras Borges , Von Dentz Maiza Cristina , Rocha Débora Santos , Model Jorge Felipe Argenta , Kowalewski Lucas Stahlhöfer , de Souza Samir Khal , de Oliveira Girelli Vitória , da Rosa Coelho Jerônimo , de Souza Vargas Nathalia , Reischak-Oliveira Alvaro , de Bittencourt Paulo Ivo Homem , Wilhelm Eurico Nestor , Vinagre Anapaula Sommer , Krause Mauricio
Published: October 2024

Background: Physical inactivity induces insulin resistance (IR) and metabolic imbalances before any significant changes in adiposity. Recent studies suggest that the beneficial effects of exercise can be potentiated if performed while fasting. This work aimed to compare the subacute effects of fed- and fasted-state single-bout exercise on biochemical parameters and cellular signaling in the metabolism. Methods: The animals were allocated into fed rest (FER), fasting rest (FAR), fed exercise (FEE), and fasting exercise (FAE) groups. The exercise protocol was a 30 min treadmill session at 60% of V˙O2max. The fasting groups fasted for 8 h before exercise and were killed after 12 h post-exercise. Results: Soleus glycogen concentration increased only in the fasting groups, whereas the triglyceride (TGL) content increased in brown adipose tissue (BAT) and liver in the FAE. The FAE showed decreased plasma total cholesterol concentration compared withthe FAR group. Immunocontent of HSP70, SIRT1, UCP-1, and PGC1-α did not change in any tissue investigated. Conclusions: Our results indicate that physical exercise while fasting can have beneficial metabolic effects on sedentary animals. Remarkably, in the FAE group, there was a reduction in total plasma cholesterol and an increase in the capacity of BAT to metabolize and store nutrients in the form of TGLs.
Factors Related to Evidence-Based Practices Among Mental Health Nurses in Thailand: A Cross-Sectional Study
Authors: Manitkul Napapat , Thummathai Kwaunpanomporn , Bhatarasakoon Patraporn
Published: October 2024

Background and Objectives: Despite the robustness of evidence-based practice in increasing efficiency in nursing care and improving patient safety, using evidence in practice is still rare in mental health nursing. This correlational descriptive research aimed to explore the factors and examine the relationship between attitudes, knowledge/skills, organizational culture, mentorship, and demographic factors to evidence-based practices among mental health nurses working in psychiatric hospitals in Thailand. Methods: The sample consisted of 255 nurses working in psychiatric hospitals under the Thai Department of Mental Health, located in service units across the country’s four regions. The data collection tools included (1) a demographic questionnaire, (2) the Evidence-Based Practice Questionnaire: EBPQ, (3) Organizational Culture & Readiness for System-wide Integration of Evidence-Based Practice: OCRSIEP, and (4) the Evidence-Based Practice Mentorship Scale. Descriptive statistics and Spearman’s correlation coefficient were used for data analysis. Results: The findings revealed that the factors positively correlated with evidence-based practice among mental health nurses in Thailand were attitude with a mean score of 4.90 (r = 0.39, p-value < 0.001), knowledge/skills with a mean score of 4.69 (r = 0.61, p-value < 0.001), organizational culture with a mean score of 3.94 (r = 0.26, p-value < 0.001), and mentorship with a mean score of 2.77 (r = 0.16, p-value = 0.011). Demographic factors such as educational level (r = 0.21, p-value < 0.001) and work experience in psychiatric and mental health nursing (r = 0.14, p-value = 0.031) were also positively correlated. Conclusions: This research revealed that EBP knowledge and skills are the most significant factors related to evidence-based practice among Thai mental health nurses. Therefore, EBP knowledge and skills should be enhanced in the curriculum during the nursing study and through continuing education once nurses graduate. Organizational culture and mentorship also need to be promoted to strengthen the use of EBP in Thailand.
Understanding Viral Haemorrhagic Fevers: Virus Diversity, Vector Ecology, and Public Health Strategies
Authors: Hewson Roger
Published: October 2024

Viral haemorrhagic fevers encompass a diverse group of severe, often life-threatening illnesses caused by viruses from multiple families, including Arenaviridae, Filoviridae, Flaviviridae, Hantaviridae, Nairoviridae, Peribunyaviridae, and Phenuiviridae. Characterised by fever and haemorrhagic symptoms, these diseases challenge public health systems by overwhelming healthcare facilities, complicating diagnostic processes, and requiring extensive resources for containment and treatment, especially in resource-limited settings. This discussion explores the intricate relationships between VHFs and their transmission vectors—both animal and arthropod—and examines the impact of ecological and geographic factors on disease spread. The primary transmission of VHFs typically occurs through direct contact with infected animals or via bites from haematophagous arthropods, facilitating zoonotic and, at times, human-to-human transmission. With an emphasis on the role of diverse wildlife, domesticated animals, and vectors such as mosquitoes and ticks in the epidemiology of VHFs, there is a recognised need for robust surveillance and strategic public health responses to manage outbreaks. This review discusses the necessity of interdisciplinary approaches that integrate virology, ecology, and public health to enhance diagnostic capabilities, develop vaccines and antivirals, and improve outbreak interventions. Exploring the ecological and biological dynamics of VHFs will help bolster a deeper understanding of these emerging viruses and underpin preparation for future outbreaks. The importance of enhanced global cooperation, continuous research, and collaboration to mitigate the public health threats posed by these complex infections is a central theme, serving as a foundational strategy to reinforce worldwide preparedness and response efforts. Future directions include addressing gaps in vaccine development and tailoring public health strategies to the unique challenges of managing VHFs, such as the rapid mutation rates of viruses, the need for cold chain logistics for vaccine distribution, and socio-economic barriers to healthcare access, in order to ensure readiness for and effective response to emerging threats worldwide.
New Quinazolin-4(3H)-One Derivatives Incorporating Isoxazole Moiety as Antioxidant Agents: Synthesis, Structural Characterization, and Theoretical DFT Mechanistic Study
Authors: Rhazi Yassine , Sghyar Riham , Deak Noemi , Es-Sounni Bouchra , Rossafi Bouchra , Soran Albert , Laghmari Mustapha , Arzine Azize , Nakkabi Asmae , Hammani Khalil , Chtita Samir , M. Alanazi Mohammed , Nemes Gabriela , El. Yazidi Mohamed
Published: October 2024

Background: This research centers on the development and spectroscopic characterization of new quinazolin-4(3H)-one-isoxazole derivatives (5a–e). The aim was to investigate the regioselectivity of the 1,3-dipolar cycloaddition involving arylnitriloxides and N-propargylquinazolin-4(3H)-one, and to assess the antioxidant properties of the synthesized compounds. The synthetic approach started with the alkylation of quinazolin-4(3H)-one using propargyl bromide, followed by a 1,3-dipolar cycloaddition reaction. Methods: The structural identification of the products was performed using various spectroscopic methods, such as IR, 1H, 13C, and HMBC NMR, HRMS, and single-crystal X-ray diffraction. To further examine the regioselectivity of the cycloaddition, Density Functional Theory (DFT) calculations at the B3LYP/6-31G(d) level were employed. Additionally, the antioxidant potential of the compounds was tested in vitro using DPPH (2,2-Diphenyl-1-picrylhydrazyl)radical scavenging assays. The reaction selectively produced 3,5-disubstituted isoxazoles, with the regiochemical outcome being independent of the substituents on the phenyl ring. Results: Theoretical calculations using DFT were in agreement with the experimental results, revealing activation energies of −81.15 kcal/mol for P-1 and −77.32 kcal/mol for P-2, favoring the formation of P-1. An analysis of the Intrinsic Reaction Coordinate (IRC) confirmed that the reaction proceeded via a concerted but asynchronous mechanism. The antioxidant tests demonstrated that the synthesized compounds exhibited significant radical scavenging activity, as shown in the DPPH assay. The 1,3-dipolar cycloaddition of arylnitriloxides with N-propargylquinazolin-4(3H)-one successfully resulted in novel 3,5-disubstituted isoxazoles. Conclusions: The experimental findings were well-supported by theoretical predictions, and the antioxidant assays revealed strong activity, indicating the potential for future biological applications of these compounds.
The Key Role of Wettability and Boundary Layer in Dissolution Rate Test
Authors: Biasin Alice , Pribac Federico , Franceschinis Erica , Cortesi Angelo , Grassi Lucia , Voinovich Dario , Colombo Italo , Grassi Gabriele , Milcovich Gesmi , Grassi Mario , Abrami Michela
Published: October 2024

Background/Objectives: The present work proposes a mathematical model able to describe the dissolution of poly-disperse drug spherical particles in a solution (Dissolution Rate Test—DRT). DRT is a pivotal test performed in the pharmaceutical field to qualitatively assess drug bioavailability. Methods: The proposed mathematical model relies on the key hallmarks of DRT, such as particle size distribution, solubility, wettability, hydrodynamic conditions in the dissolving liquid of finite dimensions, and possible re-crystallization during the dissolution process. The spherical shape of the drug particles was the only cue simplification applied. Two model drugs were considered to check model robustness: theophylline (both soluble and wettable) and praziquantel (both poorly soluble and wettable). Results: The DRT data analysis within the proposed model allows us to understand that for theophylline, the main resistance to dissolution is due to the boundary layer surrounding drug particles, whereas wettability plays a negligible role. Conversely, the effect of low wettability cannot be neglected for praziquantel. These results are validated by the determination of drug wettability performed while measuring the solid–liquid contact angle on four liquids with decreasing polarities. Moreover, the percentage of drug polarity was determined. Conclusions: The proposed mathematical model confirms the importance of the different physical phenomena leading the dissolution of poly-disperse solid drug particles in a solution. Although a comprehensive mathematical model was proposed and applied, the DRT data of theophylline and praziquantel was successfully fitted by means of just two fitting parameters.
Pharmacist-Prescribed Hormonal Contraception: A Survey of Perceptions of Georgia Community Pharmacists and Non-Community Pharmacists
Authors: Stone Rebecca H. , Patel Megha D. , Beene Lara L.
Published: October 2024

Pharmacist-prescribed hormonal contraception (HC) is supported by a majority of pharmacists and pharmacy students; however, few studies have evaluated perceptions of non-community pharmacists, or differences in geographic areas. The primary objective of this study is to assess differences between community and non-community pharmacists in perceptions of pharmacist-prescribing HC in Georgia, a state that does not currently permit this practice. Secondary objectives include assessment of community pharmacist interest in prescribing HC, and differences in perceptions between pharmacists in metropolitan and nonmetropolitan areas. A survey was emailed in early 2022 to 2592 Georgia pharmacists, with Likert questions assessing interest, perceptions, comfort, and perceived barriers regarding pharmacist-prescribed HC. Chi square testing identified differences between groups. The completed survey response rate was 11.8%. Regardless of practice site, a majority agreed that pharmacists are well trained to prescribe HC (community 61.8% vs. non-community 68.1%, p = 0.25) and provision of HC services is within pharmacists’ scope (community 73.6% vs. non-community 74.2%, p = 0.90). Overall, metropolitan and nonmetropolitan community pharmacist perceptions were similar; however, more metropolitan pharmacists believed pharmacists are well trained to prescribe HC (66.7% vs. 48.7%, p = 0.049) and that it is within their scope of practice (78.1% vs. 61.5%, p = 0.045). In summary, the majority of pharmacists, regardless of practice type, believe that pharmacists are prepared to prescribe HC and that it is a part of pharmacists’ professional scope of practice.
Mechanistic Study on the Optimization of Asphalt-Based Material Properties by Physicochemical Interaction and Synergistic Modification of Molecular Structure
Authors: Cao Jiashuo , Wang Lifeng
Published: October 2024

In order to investigate the relationship between the molecular structure of fibers and the differences in physicochemical interactions between fibers and asphalt on the performance of fiber-modified asphalt, this paper chose two types of fibers with different chemical structures: straw fiber and polyester fiber. First, the differences in molecular interactions between the two fibers and asphalt were explored using molecular dynamics, then the differences in the adsorption capacity of the two fibers on asphalt components were tested by attenuated total reflection infrared spectroscopy experiments, and finally, the differences in the rheological properties of the two fiber-modified asphalts were tested by dynamic shear rheology and low-temperature creep experiments. The molecular dynamics simulation findings reveal that polyester fibers may intersperse into asphalt molecules and interact with them via structures such as aromatic rings, whereas straw fibers are merely adsorbed on the asphalt’s surface. Straw fibers and asphalt exhibit hydrogen bonding, whereas polyester fibers and asphalt display van der Waals interactions. The results of attenuated total reflectance infrared spectroscopy indicated that polyester fiber absorbed asphalt components better than straw fiber. The rheological tests revealed that the polyester fiber had the highest complex shear modulus in the temperature range of 46–82 °C, and at 64 °C, the phase angle was 4.289° lower than that of the straw fiber-treated bitumen. Polyester fiber-modified asphalt had a 32.48%, 15.72%, and 6.09% lower creep modulus than straw fiber-modified asphalt at three low-temperature conditions: −6 °C, −12 °C, and −18 °C. It is clear that fibers with aromatic rings as a chemical structure outperform lignin-based fibers in terms of improving asphalt characteristics. The research findings can serve as a theoretical foundation for the selection of fibers to produce fiber-modified asphalt.
Preventing Foreign Body Aspiration and Ingestion with a Damp Gauze in Clinics
Authors: Yang Jae-Ho , Lee Jae-Hyun , Yeo In-Sung
Published: October 2024

Implantable medical devices and prostheses are inherently recognized as foreign bodies by the human body [...]
Rebranding God: The Jewish Revival Movement between Homeland and Diaspora
Authors: Werczberger Rachel , Monterescu Daniel
Published: October 2024

Against the gloomy forecast of “The Vanishing Diaspora”, the end of the second millennium saw the global emergence of a dazzling array of Jewish cultural initiatives, institutional modalities, and individual practices. These “Jewish Revival” and “Jewish Renewal” projects are led by Jewish NGOs and philanthropic organizations, the Orthodox Teshuva (return to the fold) movement and its well-known emissary Chabad-Lubavitch Hasidism, and alternative cultural initiatives that promote what can be termed “lifestyle Judaism”. This range between institutionalized revival movements and ephemeral event-driven projects circumscribes a diverse space of creative agency. Indeed, the trope of a “Jewish Renaissance” has become both a descriptive category of an increasingly popular and scholarly discourse across the globe, and a prescriptive model for social action. This article explores the global transformations of contemporary Jewishness, which give renewed meaning to identity, tradition, and politics in our post-secular world in two different sociopolitical contexts. Drawing on long-term ethnographic research, we interrogate the relations between “diaspora” and “homeland” by analyzing two case studies: the Jewish revival movement in Budapest, Hungary, and the Jewish renewal initiatives in Israel. While the first instantiates a diasporic movement anchored in a post-denominational and post-secular attempt to reclaim Jewish tradition for a new generation of Jew-llennials (Millennial Jews), the second group operates against the Orthodox hegemony of the institutional Rabbinate by revisiting religious ritual and textual study. By proposing new cultural repertoires, these movements highlight the dialectic exchange between center and periphery. The ethnography of religious revival decenters the Israeli Orthodoxy as “the homeland” and positions the diaspora at the core of a network of cultural creativity and renewal, while remaining in constant dialog with Israel and other diasporic communities.
Religion, Extraction, and Just Transition in Appalachia
Authors: Witt Joseph D.
Published: October 2024

This paper employs approaches from religious studies and Appalachian studies to examine the history, influence, and future of a multifaceted ethos of extraction, particularly as it influences the coal industry, in the Appalachian region of the United States. While many studies of extraction and the coal industry focus on their economic and political dimensions, by examining a broader ethos of extraction, this paper highlights multiple religious influences, including the entanglements between religious communities and extraction-based industries, the powerful moral narratives that serve to interpret and justify extraction, and the dynamics involved in shaping local identities and perceptions of place that enable this ethos to influence post-coal transition efforts. The result is a broad survey of the influences and impacts of resource extraction in Appalachia that challenges many of the longstanding stereotypes that can still be commonly found deployed about the region. In examining these influences, the paper also describes how academic interpreters have helped to shape popular conceptions of the Appalachian region that ultimately support ongoing extractive practices. Building upon insights from grassroots, anti-extractive activist communities in the region, the paper concludes by suggesting some ways that academics might adopt restorative ethics and practices in their work to address the entanglements between extractive scholarship and exploitation and devise alternative paths for just futures.
Literature and Mysticism in the Wake of Silvano Panunzio: From The Divine Comedy to the European Literature of the Twentieth Century
Authors: Latino Piero
Published: October 2024

This article introduces one of the forgotten figures of religious and literary studies: the Italian scholar, philosopher, metaphysician, poet and writer Silvano Panunzio (1918–2010). His contribution has so far been relegated to the margins of academic debate, and, currently, there are no academic studies on his work, in which mysticism plays a pivotal role. Panunzio believed that the transcendental and mystical dimension is fundamental for fully understanding the social, cultural, historical and political events of humanity. Another relevant aspect of his work is the importance he gave to literature and its relationship with mysticism, as in the case of Dante’s Divine Comedy or other European and Eastern writers and poets, such as Goethe, Shakespeare, Ibn Arabi and Dostoevsky. Significantly, Panunzio saved from oblivion the work of a forgotten man of letters of the nineteenth century, Gabriele Rossetti (1783–1854), who proposed the first symbolic and esoteric interpretation of Dante’s literary production and of European medieval love literature. Raising awareness of the intellectual amnesia around the figure of Silvano Panunzio may be a useful contribution to future research, both in the field of religious and literary studies.
Myth, Religion, Imagination, and (Virtual) Realities
Authors: Boscaljon Daniel
Published: October 2024

This article provides a way to think through the division between religious and secular approaches to contemporary society through the use of rival myths. Myths are narrative structures that invite the interplay of language and the imagination, resulting in the creation of virtual realities and social imaginaries. Strong virtual realities were once premised on myths that guided the imagination to embrace an openness to mystery and the unknowable; however, current technological culture is predicated on a closed imagination that has led to worldwide despair. Religion was originally grounded in the virtual reality inspired by language and the capacity of language to distill and extract the “virtual” from the real. The ability of language to create a virtual reality created the capacity to think of a soul, as well as destinations for the soul. In the twentieth century, Freud found that the notion of “God” that was created had become problematic for humans and so created a modern myth that would provide a secular substitute. After providing a close reading of Freud’s governing myth for modern culture, showing how it inspires the imagination and the ways in which it falls short, this article concludes with an alternative myth—that of the Invisible City—proposed to inspire faith, hope, and love in our modern world. My approach relies on a depth psychological framework, which was formed to interrogate the nature of reality (relative to individuals and culture) at the intersection of myth, religion, language, and imagination. Throughout, I use a hermeneutic methodology, which is consistent with the initial mode of depth psychological exploration as well as the central role language plays in revealing the truth of a reality. This orientation enables an exploration of a deeper sense of virtual realities than what is deployed through current technology.
Mapping Human Pressure for Nature Conservation: A Review
Authors: Luo Quanxin , Li Shicheng , Wang Haifang , Cheng Haonan
Published: October 2024

The escalating human pressures on natural ecosystems necessitate urgent and effective conservation strategies to safeguard biodiversity and ecosystem functions. This review explored current techniques for mapping human pressure, with a particular focus on their application in nature conservation, especially within protected areas (PAs). Specifically, we analyzed the impacts of seven major types of human pressures on nature conservation within PAs. Additionally, we discussed four key methods for mapping human pressure, including land use intensity, human footprint, digital human footprint, and other proxies, examining their distinct characteristics and respective advantages and disadvantages. Additionally, our research explored the application of human pressure mapping for nature conservation, assessing its suitability for conservation applications and delineating directions for future work. These insights contributed to better support nature conservation and the management of PAs.
Comparison of Non-Contact Measurement Technologies Applied on the Underground Glacier—The Choice for Long-Term Monitoring of Ice Changes in Dobšiná Ice Cave
Authors: Dušeková Laura , Herich Pavel , Pukanská Katarína , Bartoš Karol , Kseňak Ľubomír , Šveda Jakub , Fehér Ján
Published: October 2024

Because of the international significance of Dobšiná Ice Cave (Slovakia), it is important to have proper data about the state, movement, or decrease of the ice in which various information about past environments can be preserved. Thus, the goal of the study is to find out which of the 3D scanners used here is the most suitable for long-term monitoring of ice changes. A comparison of the 3D point clouds acquired from laser scanners Leica C10 and Leica RTC360 and the mobile scanners GeoSLAM Zeb Horizon and the iPhone 14 Pro to reference clouds from photogrammetry or tacheometry is provided, and also the process of data acquisition and registration is described. To catch the differences in point clouds according to different types of ice, cross-sections of the vertical and layered ice wall, horizontal ice surface, and artificial ice tunnel are analysed. Some remarkable but also unwanted properties of 3D scanners have been concluded, and the best compromise for 3D scanning of this ice cave has been chosen. According to the diversity of ice types and different layers occurring in Dobšiná Ice Cave, results could be partially helpful in choosing a suitable measurement technology for ice in other caves worldwide.