bluuebunny/crossref_metadata_2025 huggingface dataset:
Parameter Estimation of Power System Oscillation Signals under Power Swing Based on Clarke–Discrete Fourier Transform
Authors: Song Jian , Shan Xuansheng , Zhang Junhao , Wen He
Published: January 2024

Accurate knowledge of oscillation parameters (i.e., frequency, amplitude, phase, and damping factor) is crucial for control strategies of power systems under power swing. This paper presents a method for the parameter estimation of power system oscillation signals under power swing based on Clarke–DFT. The proposed method provides accurate parameter estimation of damped sinusoidal signals for both balanced and unbalanced systems, which performs well even in the presence of harmonics. In the meantime, the negative frequency components in the spectra of the damped sinusoidal signals, which are caused by system imbalance, are calculated accurately using complex-valued interpolated DFT. To verify the performance of the proposed method, simulations are performed under balanced and unbalanced conditions. The results of the simulations confirm the effectiveness of the proposed method either in unbalanced or harmonic conditions.
Enhancing the Robustness of Traffic Signal Control with StageLight: A Multiscale Learning Approach
Authors: Su Gang , Yang Jidong J.
Published: January 2024

The continuous evolution of artificial intelligence and cyber–physical systems has presented promising opportunities for optimizing traffic signal control in densely populated urban areas, with the aim of alleviating traffic congestion. One area that has garnered significant interest from both researchers and practitioners is the application of deep reinforcement learning (DRL) in traffic signal control. However, DRL-based algorithms often suffer from instability due to the dynamic nature of traffic flows. Discrepancies between the environments used for training and those encountered during deployment often lead to operational failures. Moreover, conventional DRL-based traffic signal control algorithms tend to reveal vulnerabilities when faced with unforeseen events, such as sensor failure. These challenges highlight the need for innovative solutions to enhance the robustness and adaptability of such systems. To address these pertinent issues, this paper introduces StageLight, a novel two-stage multiscale learning approach, which involves learning optimal timings on a coarse time scale in stage 1, while finetuning them on a finer time scale in stage 2. Our experimental results demonstrate StageLight’s remarkable capability to generalize across diverse traffic conditions and its robustness to various sensor-failure scenarios.
Lactic Acid Bacteria-Fermented Diet Containing Bacterial Extracellular Vesicles Inhibited Pathogenic Bacteria in Striped Beakfish (Oplegnathus fasciatus)
Authors: Lee Bao-Hong , Hu Yeh-Fang , Chu Yu-Ting , Wu Yu-Sheng , Hsu Wei-Hsuan , Nan Fan-Hua
Published: January 2024

In recent years, probiotics have received considerable attention for improving the health of aquaculture organisms, such as fish and shrimp, by stimulating immune activity and increasing growth rates. Oplegnathus fasciatus is a common and economically important cultured fish species in Asia. In this study, we aimed to investigate the potential of lactic acid bacteria (LAB; Limosilactobacillus reuteri)-fermented feed to promote growth and enhance immune function in O. fasciatus. The feed contained the highest proportion of LAB after L. reuteri fermentation for 3 days in anaerobic conditions. Oplegnathus fasciatus was fed LAB-fermented feed for 30 days. The administration of LAB-fermented feed (live bacteria > 109 CFU/g) significantly increased the growth rate (weight gain = 174.8%; FCR = 4.23) and intestinal probiotic levels of O. fasciatus. After LAB-fermented feeding, the immunity index was evaluated by superoxide anion production, the phagocytic activity of leukocytes, and bactericidal and lysozyme activities in the serum of O. fasciatus. We found that LAB-fermented feed treatment potentially elevated the proportions of intestinal Bifidobacterium, Blautia, and Dorea species and reduced pathogenic bacterial growth (Acinetobacter, Escherichia_Shigella, and Megasphaera) in O. fasciatus. This study demonstrated that LAB-fermented feed containing extracellular vesicles improves growth performance and the inhibition of pathogenic Acinetobacter baumannii.
Fu Loose Tea Administration Ameliorates Obesity in High-Fat Diet-Fed C57BL/6J Mice: A Comparison with Fu Brick Tea and Orlistat
Authors: Liang Yan , Wu Fanhua , Wu Daying , Zhu Xiaofang , Gao Xin , Hu Xin , Xu Fangrui , Ma Tianchen , Zhao Haoan , Cao Wei
Published: January 2024

Fu tea is receiving increasing attention for its specific aroma, flavor, and dramatic functional benefits. Herein, we explored the effects and underlying mechanisms of Fu loose tea (FLT), Fu brick tea (FBT), and diet pills (orlistat) on a high-fat diet (HFD)-induced obesity. The results indicated that FLT and FBT administration effectively inhibited weight gain, glucose metabolic dysregulation, fat accumulation in organs, hepatic and kidney injury, and oxidative stress induced by HFD. Additionally, FLT and FBT treatments improved the lipid profiles and reduced the production of proinflammatory cytokines by regulating the expression levels of lipid metabolism- and inflammation-related genes. Furthermore, FLT and FBT ameliorated the gut microbiota dysbiosis in HFD-mice in a dose-dependent relationship by increasing the abundance of family Verrucomicrobiaceae and genus Akkermansia and Turicibacter and simultaneously reducing the abundance of family Erysipelotrichaceae and genus Bifidobacterium; in contrast, orlistat did not exert a regulatory effect on gut microbiota similar to FLT and FBT to improve HFD-induced obesity. KEGG analysis of gut microbiota annotation revealed that “metabolism” was the most enriched category. This study further provides a theoretical basis for FLT and FBT to be potential supplements to alleviate diet-induced obesity.
A Comprehensive Analysis of Organic Food: Evaluating Nutritional Value and Impact on Human Health
Authors: Rahman Azizur , Baharlouei Parnian , Koh Eleanor Hui Yan , Pirvu Diana Gabby , Rehmani Rameesha , Arcos Mateo , Puri Simron
Published: January 2024

In recent years, organic agriculture has gained more popularity, yet its approach to food production and its potential impact on consumers’ health and various environmental aspects remain to be fully discovered. The goal of organic farming practices is to maintain soil health, sustain ecological systems, maintain fairness in its relationship with the environment and protect the environment in its entirety. Various health benefits have been associated with higher consumption of organic foods. This review identified some of these health benefits, including a reduction in obesity and body mass index (BMI), improvements in blood nutrient composition as well as reductions in maternal obesity and pregnancy-associated preeclampsia risks. Furthermore, organic food consumption can reduce the development of non-Hodgkin lymphoma (NHL) and colorectal cancers. Upon reviewing the existing literature regarding the nutritional value of organic foods, it was found that organic food contained higher levels of iron, magnesium and vitamin C. However, the evidence available to draw definitive causations remains limited due to study biases, short study durations and confounding variables; thus, it cannot be concluded that the organic diet provides any related health benefits. In this review, we provided essential insights and statistical analysis from the evidence available and consider study limitations to evaluate the potential of organic food consumption in positively impacting human health.
Chemical Characterization of 29 Industrial Hempseed (Cannabis sativa L.) Varieties
Authors: Arango Sheyla , Kojić Jovana , Perović Lidija , Đermanović Branislava , Stojanov Nadežda , Sikora Vladimir , Tomičić Zorica , Raffrenato Emiliano , Bailoni Lucia
Published: January 2024

Hemp is considered one of the potential novel crops for human and animal nutrition. This study aimed to determine the complete chemical composition of 29 different varieties of whole hempseeds. Fatty acid composition, amino acid profile, mineral composition, and cannabinoids content were also evaluated. All hempseed varieties were milled to obtain whole hempseed flour. Differences between hempseed varieties were significant (p < 0.05) for all measured parameters. Proximate composition results showed that crude protein and fat contents varied from 21.6–28.9% and 21.1–35.7%, respectively. Fatty acid profiles revealed that the three major fatty acids were linoleic acid (52.79–57.13%) followed by α-linolenic acid (12.62–20.24%), and oleic acid (11.08–17.81%). All essential amino acids were detected in all varieties, with arginine (12.66–17.56 mg/100 g protein) present in abundance, whereas lysine was limiting. Substantial differences were found in the mineral content, and potassium (509.96–1182.65 mg/100 g) and iron (5.06–32.37 mg/100 mg) were the main macro- and microminerals found. All cannabinoids were found in small traces and tetrahydrocannabidiol (THC) was only detected in five varieties. To conclude, the nutritional composition of hempseeds with hull makes them suitable to be added into the diets of humans or animals as a highly beneficial novel ingredient.
Pore Structure Quantification and Fractal Characterization of MSA Mortar Based on 1H Low-Field NMR
Authors: Jiang Zhen , He Huan , Tian Guanglin , Guo Weizuo , Li Yingzhen , Pan Zheng
Published: January 2024

With the gradual depletion of natural sand due to over-exploitation, alternative building materials, such as manufactured sand aggregate (MSA), have attracted much attention. In order to interpret the evolution of pore structure and fractal characteristics in MSA mortar over long-term water saturation, the 1H low-field nuclear magnetic resonance (LF-NMR) relaxation method was used to investigate the temporal evolution of the pore structure in five single-graded MSA mortars and synthetic-graded mortars with small amplitudes in particle size. MSA presents a fresh rock interface characterized by a scarcity of pores, which significantly reduces the porosity of the mortar. The surface-to-volume ratio (SVR) is employed for characterizing the MSA gradation. Through an analysis of parameters, such as total porosity, pore gradation, pore connectivity, and pore fractal dimension of mortar, a correlation model between pore structure parameters and aggregate SVR is constructed. The fractal characteristics of pores and their variations are discussed under three kinds of pore gradations, and the correlation model between fractal dimension and porosity is established. These results demonstrate the high impermeability and outstanding corrosion resistance of synthetic-graded mortar. The fractal model of the pore structure evolution of MSA mortar has a guiding effect on the pore distribution evolution and engineering permeability evaluation of MSA mortar in engineering.
The Dual Cardiovascular Effect of Centrally Administered Clonidine: A Comparative Study between Pentobarbital- and Ketamine/Xylazine-Anesthetized Rats
Authors: Matsubara Natália Kimie , da Silva-Santos José Eduardo
Published: January 2024

The administration of the α2-adrenergic receptor agonist clonidine via intracerebroventricular route produces hypotension in pentobarbital-anesthetized rats and pressor responses in conscious normotensive rats. We explored the impact of different anesthetics on the central nervous system-dependent cardiovascular effects of clonidine. Normotensive male Wistar rats with guide cannulas previously implanted in the cerebroventricular system were anesthetized with pentobarbital or ketamine/xylazine and prepared for blood pressure measurement. The animals received intracerebroventricular injections of 10 μg clonidine or 0.6 μg dexmedetomidine, and the effects on the systolic, diastolic, mean arterial pressure, and heart rate were evaluated. The influence of 5 μg yohimbine, a selective α2-adrenergic receptor antagonist, was also assessed. The i.c.v. microinjection of clonidine decreased all three components of systemic arterial pressure and the heart rate of pentobarbital-anesthetized rats. On the other hand, clonidine increased the blood pressure and generated a less intense reduction in the heart rate of ketamine/xylazine-anesthetized rats. The pressor and bradycardic effects of clonidine in ketamine/xylazine-anesthetized animals were reproduced by dexmedetomidine, a more selective α2-adrenergic receptor agonist. Notably, the previous intracerebroventricular injection of yohimbine significantly inhibited the hypertensive effect of clonidine and dexmedetomidine. This study discloses that while normotensive rats anesthetized with pentobarbital show hypotensive responses, the stimulation of α2-adrenergic receptors increases the blood pressure in rats under ketamine/xylazine-induced anesthesia, reproducing the effects seen in conscious normotensive animals. Recognizing the mechanisms involved in these differences may allow us to understand better the final effects of clonidine and other α2-adrenergic receptor agonists in the central nervous system, contributing to the repurposing of these drugs.
Insights into Personal Perceptions and Experiences of Colonoscopy after Positive FIT in the Flemish Colorectal Cancer Screening Program
Authors: Hoeck Sarah , Tran Thuy Ngan
Published: January 2024

Background: A timely diagnostic colonoscopy (DC) after a positive FIT result is crucial for effective colorectal cancer (CRC) screening. In the Flemish CRC screening program (CRC-SP), 17% of FIT-positive participants had no DC in 2020. This study explores self-reported barriers, experiences, and perceptions about DC in FIT-positive participants. Methods: An online survey combining qualitative and quantitative approaches was sent by email to FIT-positive participants (November 2019–September 2020). Results: Out of 5134 invitees, 1597 respondents (31.1%) completed the survey. Among them, 77.5% had undergone/planned a DC, while 22.5% were unwilling to undergo a DC. DC perceptions, expectations, and experiences differed among groups; 57% of the ‘DC-performed’ group reported better-than-expected experiences. A substantial portion of the ‘DC-naïve’ group anticipated pain (42%) and embarrassment (30%), while the actual experience in the ‘DC-performed’ group was much lower (6.4% and 3.2%, respectively). GP advice, support from close contacts, and colonoscopy experiencers trigger DC planning, whereas lack of symptoms, false-positive perception, fears, and embarrassment were identified as barriers to DC. Conclusions: The study reveals barriers/facilitators for a DC in the Flemish CRC-SP. The findings inform targeted interventions for improved DC completion and its impact, including patient navigation and testimonial videos of ‘colonoscopy experiencers’ to address DC misperceptions.
Viral Liver Disease and Intestinal Gut–Liver Axis
Authors: Kouroumalis Elias , Tsomidis Ioannis , Voumvouraki Argyro
Published: January 2024

The intestinal microbiota is closely related to liver diseases via the intestinal barrier and bile secretion to the gut. Impairment of the barrier can translocate microbes or their components to the liver where they can contribute to liver damage and fibrosis. The components of the barrier are discussed in this review along with the other elements of the so-called gut–liver axis. This bidirectional relation has been widely studied in alcoholic and non-alcoholic liver disease. However, the involvement of microbiota in the pathogenesis and treatment of viral liver diseases have not been extensively studied, and controversial data have been published. Therefore, we reviewed data regarding the integrity and function of the intestinal barrier and the changes of the intestinal microbioma that contribute to progression of Hepatitis B (HBV) and Hepatitis C (HCV) infection. Their consequences, such as cirrhosis and hepatic encephalopathy, were also discussed in connection with therapeutic interventions such as the effects of antiviral eradication and the use of probiotics that may influence the outcome of liver disease. Profound alterations of the microbioma with significant reduction in microbial diversity and changes in the abundance of both beneficial and pathogenic bacteria were found.
The Diagnostic Accuracy of Abdominal X-ray in Childhood Constipation: A Systematic Review of the Literature
Authors: Rodriguez David Avelar , Dahlwi Ghaida , Gould Michelle , Marcon Margaret , Benninga Marc
Published: January 2024

Background: Previous systematic reviews have found insufficient and conflicting evidence for an association between the clinical and radiographic diagnosis of functional constipation. Abdominal X-ray is frequently used for the diagnosis of functional constipation in clinical practice. The objective of this study was to evaluate the diagnostic accuracy of abdominal X-ray for the evaluation of functional constipation in children. Results: Three studies were included in the final qualitative analysis. They were heterogeneous in their study design, definition of constipation, and radiologic parameters used to evaluate the abdominal X-rays. Sensitivities ranged from 73–92%, specificities ranged from 26–92%, and diagnostic accuracies ranged from 78–90%. Methods: This study involved a systematic review of English literature published between 2012 and 2022 covering children 2–18 years of age with a diagnosis of functional constipation in whom abdominal X-ray was performed. The databases searched include Medline, Embase, and Scopus. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) guidelines were followed. PROSPERO ID: CRD42022301833. Conclusions: There is insufficient evidence to support the use of abdominal X-ray as part of the diagnostic workup of functional constipation. More methodologically rigorous studies are needed to determine the utility of abdominal X-ray in the evaluation of functional constipation. The diagnosis of functional constipation should be based on history and clinical findings.
Implementation of Healthy Men Healthy Communities: A Health Promotion and Gender-Based Violence Prevention Program for Male South Sudanese Refugees in Uganda
Authors: Zielinski Ruth , Ajak Daniel Kuir , Drummond Nora , Lee HaEun
Published: January 2024

Men living in refugee settings are often exposed to violence, poverty, and social instability, which impacts physical and mental health and increases the risk of perpetrating sexual and gender-based violence. Healthy Men Healthy Communities was developed as a male-led health promotion program to address men’s physical and mental health and their role in creating healthy relationships and families. Three community leaders from the settlements were trained to facilitate the program, which was implemented among six groups consisting of twelve men in each group. Pre/post surveys and feedback were collected among the facilitators and participants. Facilitators suggested culturally appropriate ways to present physical activities as a stress reduction technique and the importance of spacing out births. The small group setting facilitated open conversations on topics such as birth spacing and healthy partner communication. Participants experienced an increase in knowledge and confidence in practicing the program content, such as stress-reduction techniques and healthy communication strategies. Participants recommended additional topics such as fertility and sexually transmitted infections. The Healthy Men Healthy Communities program has the potential for wider implementation among male South Sudanese refugees to promote their health as well as the health of their families.
Communicating Risks and Food Procedures through a Visual Poster for Caregivers of Patients with Dysphagia in Inpatient Care: Usability and Impact
Authors: Neves Rafaela Nogueira , Matos Maria Assunção , Carvalho Irene P.
Published: January 2024

Food-related procedures are a part of rehabilitation interventions for dysphagia. However, studies show that professional-caregiver communication is often lacking in dysphagia, risking caregivers’ knowledge, understanding, and practice of those procedures, with negative consequences for patient safety and rehabilitation. The aim of this study was to evaluate caregivers’ perspectives about the utility of a poster designed to communicate dysphagia-related risks and food procedures for caregivers of patients in inpatient care. The impact of caregivers’ exposure to the poster on patients’ dysphagia-related health was additionally explored. The poster was placed by the beds of a randomly assigned group of patients (n = 21). Their caregivers responded to a questionnaire about the poster’s utility. In addition, to explore whether the caregiver exposure to the poster could already have some effect on patient dysphagia-related health, patient risk of aspiration, food swallowing capacity, nutritional status, and oral cavity health were assessed before and one month after placement of the poster, and the poster-exposed group was compared with a (randomly-assigned) non-exposed group (n = 21). Data were analyzed with descriptive statistics and generalized linear models based on analyses of covariance. All caregivers across various education levels reported noticing, reading, and understanding the poster (100%). Nearly all reported that the poster added new information to their knowledge (17 out of 21). In the additional analysis, the patients in the poster-exposed group showed greater improvements in the health outcomes, compared with the non-exposed group, although the effects were statistically non-significant within this study’s one-month period. A poster with pictorial information was effective in increasing awareness about dysphagia-specific information among caregivers of patients in inpatient care and can be used as an augmentative means of information, with potential benefits for patient safety and rehabilitation.
The Effectiveness and Safety of Chuna Manual Therapy Adjuvant to Western Medicine in Patients with Chronic Obstructive Pulmonary Disease: A Randomized, Single-Blind, Investigator-Initiated, Pilot Trial
Authors: Park Jiwon , Kwon Minji , Lee Beom-Joon , Kim Kwan-Il , Jung Hee-Jae
Published: January 2024

Recently, non-pharmacological treatments are gaining increasing importance for improving the quality of life in patients with chronic obstructive pulmonary disease (COPD). This pilot study aimed to evaluate the feasibility of conducting extensive research on Chuna manual therapy (CMT). This study investigated the effectiveness and safety of CMT adjuvant to Western medicine (WM) in patients with COPD. Forty patients with COPD were randomized into two groups in a 1:1 ratio: experimental (CMT plus WM) and control (WM only) groups. The CMT intervention was administered once a week for eight weeks. The primary outcome measured was the 6-min walk distance (6MWD). Secondary outcomes measured were: forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), assessments using the modified Medical Research Council (mMRC) scale and Visual Analog Scale (VAS) for dyspnea, the COPD Assessment Test (CAT), St. George’s Respiratory Questionnaire (SGRQ), and the EuroQoL five-dimensional questionnaire (EQ-5D). The mean differences in FEV1 (L) between Weeks 1 and 8 were statistically significant between the groups (p = 0.039). Additionally, the experimental group showed improved 6MWD, mMRC, VAS for dyspnea, CAT, SGRQ (total), and EQ-VAS scores than the control group. However, the differences between the two groups were not statistically significant. No adverse events were observed during this trial. CMT has the potential to alleviate symptoms, improve quality of life, and delay the decline in lung function in patients with COPD. The results of this pilot study could lead to large-scale clinical trials in the future.
Problems and Opportunities of a Smartphone-Based Care Management Platform: Application of the Wald Principles to a Survey-Based Analysis of Patients’ Perception in a Pilot Center
Authors: Rossi Stefano Marco Paolo , Panzera Rocco Maria , Sangaletti Rudy , Andriollo Luca , Giudice Laura , Lecci Francesca , Benazzo Francesco
Published: January 2024

(1) Background: Mobile health (mHealth) solutions can become a means of improving functional recovery and reducing the peri-operative burden and costs associated with arthroplasty procedures. The aim of this study is to explore the objectives, functionalities, and outcomes of a platform designed to provide personalized surgical experiences to qualified patients, along with the associated problems and opportunities. (2) Methods: A survey-based analysis was conducted on patients who were prescribed the use of a specific care management platform and underwent primary robotic total knee arthroplasty (rTKA) between January 2021 and February 2023. (3) Results: Patients registered on the platform who have undergone primary robotic TKA (rTKA) were considered. The mean age of registered patients is 68.6 years. The male (M)/female (F) ratio is 45.1%/54.9%. The patients interviewed were at an average distance of 485 days from the intervention, with a standard deviation of 187.5. The survey highlighted appreciation for the app and its features, but also limitations in its use and in its perception by the patients. All these data were evaluated according to the Wald principles and strategies to improve patient recruitment, enhance adherence, and create a comprehensive patient journey for optimized surgical experiences. (4) Conclusions: This patient care platform may have the potential to impact surgical experiences by increasing patient engagement, facilitating remote monitoring, and providing personalized care. There is a need to emphasize the importance of integrating the recruiting process, improving adherence strategies, and creating a comprehensive patient journey within the platform.
Effectiveness of Virtual Reality Therapy on Balance and Gait in the Elderly: A Systematic Review
Authors: Rodríguez-Almagro Daniel , Achalandabaso-Ochoa Alexander , Ibáñez-Vera Alfonso Javier , Góngora-Rodríguez Jorge , Rodríguez-Huguet Manuel
Published: January 2024

Virtual reality (VR) therapies are presently utilized to treat physical and cognitive impairments among elderly people. This systematic review aims to collect the most recent evidence on the effectiveness of VR in improving balance and gait among healthy elderly individuals, in comparison with other therapies. A literature search was conducted using the PubMed, SCOPUS, PEDro, and WoS databases, by selecting randomized clinical trials that evaluated balance, both static and dynamic, as well as gait in a population of healthy older adults who underwent virtual reality therapy. The methodological quality of the studies was assessed using the PEDro scale. After eligibility criteria were applied and duplicates were removed, 20 studies were selected out of 1705 initially identified. The present systematic review concludes that virtual reality therapy is more effective than minimal intervention or usual care in enhancing static balance, dynamic balance, and gait in healthy elderly individuals. Moreover, virtual reality therapy yields better outcomes compared to traditional balance training and physical exercise in improving balance and gait in this demographic. However, both methods have shown effectiveness.
RSM and ANN Modeling of Camelina (Camelina sativa L. Crantz) Seed Yield as Affected by Nitrogen, Sulfur, Cow Manure, and Row Spacing
Authors: Yari Mohsen , Rokhzadi Asad , Shamsi Keyvan , Pasari Babak , Rahimi Abdol Rahman
Published: January 2024

Camelina [Camelina sativa (L.) Crantz] is an annual versatile oilseed crop of the Brassicaceae family, with an increasingly cultivated area. Predicting camelina seed yield response to fertilization and planting density is of great importance in understanding production potential and management planning. Therefore, the current study aimed to estimate the seed yield of camelina by response surface methodology (RSM) and artificial neural network (ANN) as affected by different levels of planting row spacing and nitrogen (N), sulfur (S), and cow manure (CM) fertilization. The experiment was conducted in two growing years of 2019–2020 and 2020–2021, based on a central composite design with four factors including row spacing (15–35 cm), N (0–200 kg ha−1), S (0–100 kg ha−1), and CM (0–40 t ha−1). The RSM models for seed yield versus fertilization and row spacing factors in both years were statistically significant and had an acceptable predictive ability. Camelina seed yield decreased with increasing row spacing but showed a positive response to increasing the amount of N, S, and CM fertilizers. Comparing the performance of the models showed that, although the RSM models were significant and had the necessary efficiency in predicting camelina seed yield, the ANN models were more accurate. The performance criteria of coefficient of determination (R2), root mean square error (RMSE), standard error of prediction (SEP), mean absolute error (MAE), and Akaike information criterion (AICc) averaged over the two years for the RSM model were 0.924, 51.60, 5.51, 41.14, and 394.05, respectively, and for the ANN model were 0.968, 32.62, 3.54, 19.55, and 351.33, respectively. Based on the results, the ANN modeling can be used in predicting camelina seed yield in field conditions with more confidence than the RSM technique.
Genotype-Specific Response to Silicon Supply in Young Tomato and Unripe Melon Plants Grown in a Floating System
Authors: Somma Annalisa , Palmitessa Onofrio Davide , D’Imperio Massimiliano , Serio Francesco , Santamaria Pietro
Published: January 2024

Agronomic biofortification of crops is a promising approach for the accumulation of Si in plant organs and can be achieved through the application of Si-containing fertilizers in the nutrient solution (NS) using a soilless technique. In the present research, a local variety of Cucumis melo L. called Carosello and two tomato hybrids, ‘Alfa 200’ (TA) and ‘Versus’ (TV), were cultivated in a floating system with three levels of Si (0, 50, and 100 mg·L−1) in the NS with the aim to study the Si translocation/accumulation in leaves, stems, and roots of these genotypes. In general, by adding Si to the NS, Si accumulation in plants increased. Regarding Si translocation, it was found that Carosello exhibited a better translocation capacity than tomato hybrids, and Si movement from roots to shoots was very much dependent on tomato genotypes. With the highest Si content in the NS, TA had a similar Si concentration in leaves and stems, while TV showed a greater Si concentration in leaves. In conclusion, Carosello landrace is confirmed as a good Si accumulator, while the tomato is confirmed as a species with low Si accumulation capacity. Nevertheless, the effectiveness of Si biofortification in tomatoes is very much dependent on the genotype.
Effect of Leading-Edge Erosion on the Performance of Transonic Compressor Blades
Authors: Hergt Alexander , Danninger Tobias , Klinner Joachim , Grund Sebastian , Beversdorff Manfred , Werner-Spatz Christian
Published: January 2024

In this paper, an experimental and numerical investigation of the effect of leading-edge erosion in transonic blades was performed. The measurements were carried out on a linear blade cascade in the Transonic Cascade Wind Tunnel of DLR in Cologne at two operating points with an inflow Mach number of 1.05 and 1.12. The numerical simulations were performed by ANSYS Germany. The type and specifications of the erosion for the study were derived from real engine blades and applied to the leading edges of the experimental cascade blades using a waterjet process, as well as modeled in detail and meshed within the numerical setup. Numerical simulations and extensive wake measurements were carried out on the cascades to evaluate the aerodynamic performance. The increase in losses was quantified to be 4 percent, and a reduction in deflection and a rise in pressure were detected at both operating points.
The Influence of Nusselt Correlation on Exergy Efficiency of a Plate Heat Exchanger Operating with TiO2:SiO2/EG:DI Hybrid Nanofluid
Authors: Wciślik Sylwia
Published: January 2024

This paper studies how the correlation with the Nusselt number affects the final result of the efficiency, ε, and exergy efficiency, ηex, of a chevron-type gasketed plate heat exchanger, which is installed in a typical small solar installation dedicated to single-family housing; the solar fluid is a TiO2:SiO2/EG:DI hybrid nanofluid with concentrations from 0% to 1.5% vol. The experimental model assumes constant flow of the solar fluid and varies on the domestic hot water side—from 3 lpm to 6 lpm. The inlet temperatures are 30 °C and 60 °C on the cold and hot sides of the heat exchanger, respectively. Of the six analysed correlations that showed similar trends, it is concluded that for the assumed flow conditions, geometry, and chevron angle of the plate heat exchanger, one model is the most accurate. The largest difference between the ηex values for a given concentration is 3.4%, so the exergy efficiency is not affected by the chosen Nusselt model by very much. However, the choice of correlation with the Nusselt number significantly affects the efficiency, ε; the difference between the values obtained within a given concentration is more than 40% and depends on the Reynolds number and flow. Most research discusses the scenario with the nanofluid as a coolant. This paper considers the opposite situation in which the solar fluid is a hotter working medium that transfers heat to domestic hot water installation.
Endometriosis Predictive Models Based on Self-Assessment Questionnaire, Evidence from Clinical Examination or Imaging Findings: A Narrative Review
Authors: Gkrozou Fani , Tsonis Orestis , Sorrentino Felice , Nappi Luigi , Vatopoulou Anastasia , Skentou Chara , Pandey Suruchi , Paschopoulos Minas , Daniilidis Angelos
Published: January 2024

Objective: The aim of this narrative review is to evaluate existing questionnaires on predictive models for endometriosis. These symptom-based models have the potential to serve as screening tools for adult women to detect endometriosis. Data sources: A comprehensive search of PubMed and Embase databases was conducted to identify studies on endometriosis screening. Selection of studies: The search targeted predictive models for endometriosis localisation, bowel involvement, need for bowel surgery and fertility. Due to the heterogeneity identified, a systematic review was not possible. A total of 23 studies were identified. Data extraction and synthesis: Among these studies, twelve included measures for general endometriosis, two targeted specific sites, four focused on deep infiltrating endometriosis (DIE), and three addressed the need for endometriosis-related bowel surgery. Many measures combined clinical, imaging and laboratory tests with patient questionnaires. Validation of these models as screening tools was lacking in all studies, as the focus was on diagnosis rather than screening. Conclusion: This review did not identify any fully validated, symptom-based questionnaires for endometriosis screening in adult women. Substantial validation work remains to establish the efficacy of such tools.
Esophageal Stent in Acute Refractory Variceal Bleeding: A Systematic Review and a Meta-Analysis
Authors: Songtanin Busara , Kahathuduwa Chanaka , Nugent Kenneth
Published: January 2024

Background: Acute esophageal variceal bleeding accounts for up to 70% of upper-gastrointestinal bleeding in cirrhotic patients. About 10–20% of patients with acute variceal bleeding have refractory bleeding that is not controlled by medical or endoscopic therapy, and this condition can be life-threatening. Balloon tamponade is a long-standing therapy which is only effective temporarily and has several complications, while transjugular intrahepatic portosystemic shunt (TIPS) and liver transplantation may not be readily available at some centers. The use of self-expandable metal stents (SEMSs) in refractory esophageal variceal bleeding has been studied for effectiveness and adverse events and has been recommended for use as a bridge to a more definitive treatment. Aim: To investigate the effectiveness and safety of SEMSs in managing refractory variceal bleeding. Methods: A systematic search of the MEDLINE, EMBASE, and Cochrane library databases was performed from inception to October 2022 using the following terms: “esophageal stent”, “self-expandable metal stents”, “endoscopic hemostasis”, “refractory esophageal varices”, and “esophageal variceal bleeding”. Studies were included in the meta-analysis if they met the following criteria: (1) patients’ age older than 18 and (2) a study (or case series) that has at least 10 patients in the study. Exclusion criteria included (1) non-English publications, (2) in case of overlapping cohorts, data from the most recent and/or most appropriate comprehensive report were collected. DerSimonian–Laird random-effects meta-analysis was performed using the meta package in R statistical software(version 4.2.2). Results: Twelve studies involving 225 patients with 228 stents were included in the analyses. The mean age and/or median age ranged from 49.4 to 69 years, with a male-to-female ratio of 4.4 to 1. The median follow-up period was 42 days. The mean SEMS dwell time was 9.4 days. The most common cause of acute refractory variceal bleeding in chronic liver disease patients included alcohol use followed by viral hepatitis. The pooled rate of immediate bleeding control was 91% (95% CI 82–95%, I2 = 0). The pooled rate of rebleeding was 17% (95% CI 8–32%, I2 = 69). The pooled rate of stent ulceration was 7% (95% CI 3–13%, I2 = 0), and the pooled rate of stent migration was 18% (95% CI 9–32%, I2 = 38). The pooled rate of all-cause mortality was 38% (95% CI 30–47%, I2 = 34). Conclusions: SEMSs should be primarily considered as salvage therapy when endoscopic band ligation and sclerotherapy fail and can be used as a bridge to emergent TIPS or definitive therapy, such as liver transplantation.
Tuning the Tensile and Shear Properties of a Scar Healing Composite for Mechanotherapy
Authors: Lui Kam-Che , Wang Xungai , Kan Chi-Wai
Published: January 2024

Conventional scar treatment options of single pressure garment therapy (PGT) or silicone gel sheeting (SGS, Cica-Care®, Smith and Nephew, London, UK) alone lack mechanical property tunability. This article discusses a scar healing composite (PGF-Biopor®AB, Dreve Otoplastik GmbH, Unna, Germany) and how its mechanical properties can be tuned for improved mechanotherapy. A balance between compression and tension was achieved by tuning the tensile and shear properties, facilitating tension shielding and pressure redistribution for scar therapeutics. Biopor®AB-wrapping on biaxial-tensioned pressure garment fabric (PGF) allowed compression therapy and internal pressure redistribution. The Biopor®AB surface, with a coefficient of friction close to 1, strategically localizes stress for effective tension shielding. A substantial five-fold reduction in silicone tension, amounting to 1.060 N, achieves tension shielding and pressure redistribution. Simultaneously, a dynamic internal pressure-sharing mechanism distributes 0.222 kPa from each SPK-filament bundle, effectively managing internal pressure. Alongside the principle compression-silicone dual therapy, this composite design with dynamic internal pressure sharing and mechanical property tunability provides an additional pressure-relieving strategy for multiple scar therapeutics.
Human Metastatic Melanoma Cell Lines Panel for In Vitro and In Vivo Investigations
Authors: Kosobokova Ekaterina N. , Kalinina Nadezhda A. , Konoplina Ksenia M. , Malchenkova Anastasiia A. , Evdokimova Alexandra E. , Piniugina Marina V. , Khan Irina I. , Kislyak Ilya A. , Basharina Anna A. , Grishanina Anna N. , Rudakova Anna A. , Varaksa Pavel O. , Baryshnikova Maria A. , Pokrovsky Vadim S. , Bogush Tatiana A. , Kosorukov Vyacheslav S.
Published: January 2024

The melanoma origin of cell lines obtained from the axillary lymph node (mel Kas, mel Pet, and mel Lap from patients with a verified diagnosis) was confirmed by the detection of the Melan A melanocyte marker expression. A hyperdiploid (2n+) for the mel Kas line; near-diploid (2n), and in some cells near-tertaploid (4n), and even hypo-octaploid (8n) set (172–179 chromosomes) in the mel Pet cell line; and a hypotetraploid (4n−) for the mel Lap line were detected by karyotypic analysis. All three cell lines are tumorigenic; however, mel Pet demonstrates tumor growth in Balb/c nude mice only in the presence of matrigel. All three lines showed a high expression of TUBB3 and PD-L1 markers, while ERa was low (minimum for mel Pet). Significant differences in the expression level were shown for the Cyt molecular marker. In the transplantation of cells to Balb/c nude mice, a stable expression level is observed only for TUBB3. For the rest of the markers, a decrease in their expression level of varying degrees was noted when the cells were growing in solid tumors in vivo. Mutations were detected in oncogenes (BRAF, EZH2, KIT, KRAS, NRAS, ROS1) and tumor suppressor genes (CDKN2A, FAT4, KMT2C, LRP1B, PTEN, PTPRB, TP53). The detailed characterization of the cell lines makes them valuable for various scientific and regulatory experiments, particularly those involving preclinical data on antiproliferative drugs for malignant melanoma or investigations into melanoma cell properties and progression.
Power Prediction and Manoeuvring Study for an Inland Class Vessel
Authors: Islam Hafizul , Rahaman Md. Mashiur
Published: January 2024

The paper explores the propulsive power requirements and manoeuvring capabilities of a popular class of inland bulk carriers in Bangladesh. After the initial verification study, model-scale CFD simulations are performed in calm, open waters at different speeds to assess hull resistance. The resistance results are then extrapolated to full scale for calculating propulsion power requirements. Subsequently, manoeuvring simulations are performed using PMM motions to evaluate static drift, pure sway, and pure yaw scenarios to calculate manoeuvring coefficients. Following this, model-scale resistance simulations in restricted waters are performed to estimate the minimum power needed for propulsion in heavy monsoon currents based on common inland waterway dimensions in Bangladesh. Finally, full-scale simulations are performed in open water to investigate the scale effect on resistance (thus power) prediction. The study confirms that the installed power in the vessel is adequate for safe navigation within Bangladesh’s inland waters. Although model-scale CFD studies are generally unsuitable for resistance prediction, the study suggests that extrapolated results often offer conservative estimates for power prediction. In cases of resource limitation, these simulations can prove beneficial since conservative estimations somewhat ensure the vessel’s propulsion and manoeuvrability in extreme conditions.
An Out-of-Plane Bending Fatigue Assessment Approach for Offshore Mooring Chains Considering the Real-Time Updating of Interlink Bending Stiffness
Authors: Wang Junrong , He Chunlei , Fu Dianfu , He Kuang , Du Junfeng
Published: January 2024

Fatigue failure caused by frequent tension and bending loads is a crucial safety concern for mooring chains used on floating structures in the oil and gas industry. The bending effect for a chain’s fatigue is usually not considered by existing fatigue analysis methods, and even if it is considered, existing commercial software can only calculate the constant interlink bending stiffness without consideration of the stiffness variations due to tension and friction. To address this issue, this study develops an in-plane bending (IPB)/out-of-plane bending (OPB) fatigue assessment approach for offshore mooring chains considering the time-varying nonlinear interlink bending stiffness. Initially, the mooring tension and IPB/OPB angles are calculated by an in-house code MeCAP (multi-element coupled analysis program), considering the time-varying interlink stiffness between the chain links. The fatigue life of mooring chains for pure tension–tension (TT) and OPB combined fatigue at different hotspot locations (A, B, and C) is calculated by MeCAP-fatigue, a newly-developed module in MeCAP. Based on the analysis model, a comparative study is implemented to investigate the effects of interlink stiffness on fatigue damage. The differences and advantages of the combined fatigue calculation method over the pure TT fatigue assessment method are discussed. The results illustrate that combined fatigue would be underestimated significantly if zero interlink stiffness (hinge joint assumption) is applied or even constant interlink stiffness (calculated by mooring pretension), while pure TT fatigue will be largely unaffected. Moreover, compared to pure TT fatigue, the OPB combined fatigue assessment method, considering the effects of OPB/IPB and the time-varying properties of the connection between chain links, could evaluate fatigue life more comprehensively.
Robust Underwater Acoustic Channel Estimation Method Based on Bias-Free Convolutional Neural Network
Authors: Wang Diya , Zhang Yonglin , Wu Lixin , Tai Yupeng , Wang Haibin , Wang Jun , Meriaudeau Fabrice , Yang Fan
Published: January 2024

In recent years, the study of deep learning techniques for underwater acoustic channel estimation has gained widespread attention. However, existing neural network channel estimation methods often overfit to training dataset noise levels, leading to diminished performance when confronted with new noise levels. In this research, a “bias-free” denoising convolutional neural network (DnCNN) method is proposed for robust underwater acoustic channel estimation. The paper offers a theoretical justification for bias removal and customizes the fundamental DnCNN framework to give a specialized design for channel estimation, referred to as the bias-free complex DnCNN (BF-CDN). It uses least squares channel estimation results as input and employs a CNN model to learn channel characteristics and noise distribution. The proposed method effectively utilizes the temporal correlation inherent in underwater acoustic channels to further enhance estimation performance and robustness. This method adapts to varying noise levels in underwater environments. Experimental results show the robustness of the method under different noise conditions, indicating its potential to improve the accuracy and reliability of channel estimation.
Exploring the Affiliation of Corporate Social Responsibility, Innovation Performance, and CEO Gender Diversity: Evidence from the U.S.
Authors: Hassan Abeer , Atif Sehrish , Zhang Jiayi
Published: January 2024

This paper examines the relationship between CSR activities and innovation performance with the moderating effect of CEO gender in the U.S. market. This paper provides evidence about the relationship between CSR and innovation performance from the resources-based views by replacing the common measurements of innovation and R&D expenditures with the number of patents and citations to better measure the innovation quality rather than quantity. The current paper verifies the relationship between CSR and innovation in S&P 500 U.S. listed companies and fills the gaps in the current research on the moderating effect of CEO gender on this relationship. The paper analyzed the panel data for 1204 observations from various databases (Compustat, KLD, U.S. patents by words and Excompustat) from 2014 to 2018. Specifically, the number of patents and citations is set as the measurement of the explanatory variable; innovation performance and CSR scores from KLD are treated as the dependent variable and the proportion of female directors in the top management as the method of moderating indicator. The result in this paper shows a positive correlation between CSR and innovation performance in the U.S. At the same time, the moderating effect of CEO gender has an insignificant impact on this relationship. The findings suggest that the female CEOs do not have a positive relationship with corporate innovation. These results will help companies realize the importance of CSR activities and how to balance gender diversity in their strategies.