bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Insulin Resistance on Vascular Remodeling in Comorbidity of Arterial Hypertension and Obesity
Authors: В. Г. Псарьова  , Н. М. Кириченко  , М. М. Кочуєва
Published: February 2020

The objective: to evaluate the effect of insulin resistance on vascular remodeling in patients with comorbidity of arterial hypertension and obesity.Materials and methods. We examined 200 patients with hypertension and obesity class I-II. The patients were divided into two groups depending on the presence of insulin resistance: the first group included 80 patients without insulin resistance, and the second – 120 patients with insulin resistance.Results. in comorbidity of hypertension and obesity the presence of insulin resistance affects the severity of vascular remodeling. In the presence of insulin resistance, hypertensive patients with concomitant obesity have significantly higher intima-media thickness of the carotid artery at the level of bifurcation, the pulse wave velocity in the carotid artery and abdominal aorta, as compared to patients without insulin resistance. In patients with comorbidity of hypertension and obesity, HOMA-IR directly correlates with such parameters of vascular remodeling as the intima-media thickness (including at the level of bifurcation), the pulse wave velocity in the carotid artery and the abdominal aorta. In hypertensive patients with obesity in the absence of insulin resistance, an increase in HOMAIR is associated with an increase in the pulse wave velocity of the carotid artery, and in patients with insulin resistance – with an increase in the intima-media thickness of the carotid artery.Conclusion. In the future, it is necessary to assess the effect of IR on the hemodynamic and metabolic parameters of patients with hypertension and concomitant obesity.
Arterial Hypertension and Comorbid Chronic Obstructive Pulmonary Disease: Quality of Life and Structural and Functional State of the Heart
Authors: Т. З. Буртняк  , В. А. Потабашній  , В. І. Фесенко
Published: February 2020

The objective: to analyze the quality of life of patients with arterial hypertension (AH) in combination with chronic obstructive pulmonary disease (COPD), depending on clinical groups of COPD and structural and functional indicators of the heart.Materials and methods. The study included 70 men with arterial hypertension combined with COPD with clinical groups A, B, C, D, which formed the main group and 30 healthy people – the control group. Patients’ quality of life (QOL) was evaluated using the Short Form Medical Outcomes Study (SF-36) and the State George Respiratory Questionnaire (SGRQ).Results. An analysis of the SF-36 questionnaire revealed changes in the role of physical problems and general health in clinical group C established through influence the severity of hypertension. The deterioration of the psychological component is appointed to the decrease in indicators of life activity in clinical group B and C and the role of emotional state in clinical group C, which testifies to the influence of the severity of bronchial obstruction of COPD and the grade of hypertension in this group of patients. According to SGRQ, the most pronounced symptomatology and impact of the disease on the general condition of the organism is noted in patients in clinical group D.Conclusion. It was found that in patients with combined pathology of hypertension and COPD, all indicators of mental and physical health were significantly reduced. The mutual aggravating effect of the limited physical and psychological vital activity of the organism on the hemodynamic condition, which is manifested by the change of the structural-functional state of the heart in patients with hypertension in combination with COPD, has been established.
Assessing the Relationship of Levels of Brain Natriuretic Peptide with the Severity of Clinical Symptoms and Quality of Life Indicators for Patients with Chronic Obstructive Pulmonary Disease
Authors: Бен Аммар Сауссен  , О. С. Коміссарова  , Н. В. Кіча  , Л. В. Черкашина
Published: February 2020

The relationship between the severity of clinical symptoms and the level of brain natriuretic peptide (BNP) in patients with chronic obstructive pulmonary disease (COPD) was revealed, which also explains the relationship with the processes of myocardial remodeling, since the BNP level in this case can be considered as a connecting pathogenic link. Graphical and analytical (polynomial) models were constructed to reflect the dependence of the BNP level on the severity of clinical symptoms and the level of the impact of the disease on the quality of life of patients with COPD, the use of which allows us to determine the predicted BNP levels.
The Effect of Ultra-high Frequency Electromagnetic Radiation on Cognitive Function and Sleep in Patients with Arterial Hypertension
Authors: А. А. Воронко  , В. С. Потаскалова  , А. В. Ткачов  , O. В. Селюк
Published: February 2020

The objective: of the work is to evaluate the influence of ultra high frequencies of electromagnetic radiation (EMF NMS) as an additional risk factor for the development of cognitive impairment in hypertension (hypertension).Materials and methods. 47 patients with AH at the age of 28–44 years (average age (30±5 years) were examined, they worked under conditions of excessive EMR NICH for a period of 4 to 22 years (average 15,0±5,9 years) and 46 patients with hypertension of the corresponding age and form of the disease (control group), which were not influenced by EHF EMF. Cognitive functions (CF) were determined using neuropsychological tests: the Ellis test (graphomotor function), direct and reverse repetition of digital series (successive functions), and cognitive function parameters on the Mini-Mental State Examination scale.Results. In patients with hypertension and the group, a decrease in motor, successive and graphomotor functions to the level of mild and moderate disorders was revealed. In group I patients, cognitive dysfunctions on the MMSE scale were revealed, their intensity was mild, but on average it was significantly more pronounced compared with group III patients (22,05±3,3 versus 26,2±2,2; р<0.001) at normal values of 28–30. Analyzing the results of the examination in men of group II, revealed significant changes from the CNS (motor functions were 8,2±0,4 points against 9,2±0,9 points in healthy men (р<0,05); successive functions, respectively 8,6±0,5 vs. 9,6±0,4 (р<0,05); graphomotor functions – 13,4±1,5, respectively, against 17±1,6 (р<0,05). The level of reactive anxiety in patients operating under conditions of microwave EMF was significantly higher (41,9±2 points versus 35,6 points; р<0,05) than in healthy men and patients in the comparison group. In patients of group I, sleep less than 6 hours was observed in 92% (including less than 5 hours in 38%); from 6 to 7 hours – in 8% of patients. In patients of group III, sleep duration from 6 to 7 hours was noted by 86%, 8 or more hours by 14% of the examined patients. Analyzing the quality of sleep (duration, nocturnal awakening, falling asleep, feeling brisk in the morning after awakening, having dreams), we obtained the following results: sleep disturbance among patients in group I was observed in 80%, whereas in patients in group III – only 35% (р<0,05). When comparing the results obtained in the surveyed group II men revealed a decrease in sleep duration and more common sleep disorders compared with healthy men and patients in group III.Conclusion. Thus, in patients with hypertension and healthy men, who are under the influence of ultrahigh frequencies of electromagnetic radiation for a long time, lesions of the nervous system in the form of impaired cognitive function with development of vascular dementia of mild degree were revealed. The correlation between the time of work under the influence of the ESA and the violations found.
Non-pharmacological and Food Gout Management: Current and Future Directions
Authors: І. Ю. Головач  , Є. Д. Єгудіна
Published: February 2020

Gout is an inflammatory arthritis caused by the deposition of sodium monourate crystals in the synovial joints and soft tissues. Current guidelines focus more on aggressive drug therapy for the treatment of gout, while less attention is paid to recommendations for lifestyle changes and appropriate nutrition. This literature review provides a thorough analysis of the lifestyle impact, foods and food components on the risk of hyperuricemia developing, gout and its clinical manifestations, based on the most recent studies. The mechanisms underlying the influence of the characteristics of certain products on the level of serum uric acid are considered. The importance of dietary counseling for patients with gout, the need for weight control and regular moderate exercise to improve the prognosis of the course of this disease are emphasized.
Immunological Aspects of Good-quality Dysplasia of Mammary Glands at Women of Reproductive Age
Authors: С. Є. Гладенко
Published: February 2020

The objective: to study modern immunologic aspects of good-quality dysplasia of mammary glands at women of reproductive age.Materials and methods. Were surveyed 90 patients aged from 22 till 45 years which are divided into 3 groups on 30 women: 1 group (group of control) – the woman without pathology in mammary glands. The 2nd group included patients with diffuse form of good-quality dysplasia of mammary glands. The 3rd group was made by patients with a nodal form of a good-quality dysplasia of mammary glands. The complex the researches included clinical, immunologic and statistical methods.Results. Results of the conducted researches testify that it is possible to refer existence of chronic extragenital diseases, smoking, an early menarche to risk factors of development of a good-quality dysplasia of mammary glands, disturbances of a menstrual cycle, hysteromyoma and an adenomyosis, an artificial or spontaneous abortion. The research conducted by us proved that immunologic determinants play an essential role and are risk factors and an initial link of pathogenesis of benign pathology of mammary glands.Conclusion. The received results need to be considered when developing algorithm of diagnostic and treatment-and-prophylactic actions.
Actual Aspects of Pathogenesis of Dysplasia of Mammary Glands and Hysteromyoma at Women of Perimenopause Age
Authors: О. Ю. Крук
Published: February 2020

The objective: to study actual aspects of pathogenesis of dysplasia of mammary glands in combination with hysteromyoma at women of perimenopause age.Materials and methods. 50 patients with dysplasia of mammary glands (25 women from diffuse and 25 women with the localized forms) and a hysteromyoma was created. We developed the program of researches providing carrying out: clinical-statistical analysis, complex hormonal researches, X-ray inspection of mammary glands, ehografical of researches of genitalias and mammary glands, cytologic and histological methods with puncture biopsy application that mathematical processing.Results. Highlights of pathogenesis of dysplasia of mammary glands and hysteromyomas are clinical-anamnestic data, and also change of ratio of levels of hypotalamo-hypophysial hormones, the ovarium of hormones in the form of the absolute or relative giperestrogeniya, more expressed at patients with the localized forms. Disturbances of normal menstrual cycle are taped at 76% of patients, disbiotical processes of genitalias – at 46% of women with dysplasia of mammary glands.Conclusion. The received results needs to be used when developing complex of diagnostic and treatment-and-prophylactic actions.
Medical-social Features of Married Couples with Sterility
Authors: О. О. Берестовий
Published: February 2020

The objective: to study modern medico-social features at sterility of married couples.Materials and methods. Object of research about married couples with barrenes, sampling unit – each sterility married couple. 100 married couples with sterility were us study, representative selection on quality and quantity with use of method of a systematic random sample was thus formed.Results. The received results – results of the conducted researches testify that medical-social factors are of great importance for the solution of a question of realization of genesial function at married couples. Major importance has condition of genesial health not only the woman, but also the husband or the partner, and also conservation of staging of carrying out specialized medical care, since women consultation and finishing specialized clinics of auxiliary reproductive technologies.Conclusion. The conclusion – the received results needs to be considered when rendering medical care to married couples with disturbance of reproductive function.
Tindak Tutur Kesantunan Guru dan Siswa dalam Pembelajaran Bahasa Indonesia di SMP Negeri 2 Sakra: Tinjauan Pragmatik
Authors: Badelah Badelah , Mahsun Mahsun , Burhanuddin Burhanuddin
Published: February 2020

This study aims to describe the type, and speech act strategy of teacher and student politeness in learning Indonesian in class VIII SMP Negeri 2 Sakra. The method used for data collection, namely observation, recording, and interviews. The results of the study show: (1) formalities between teachers and students always pay attention to the speech events when speaking; (2) speakers are always prejudiced towards the speech partners; (3) speakers are able to distinguish between conveying situations, namely serious situations and joking situations; (4) the types of teacher and student directive speech acts in Indonesian language learning in the classroom in the form of governing and the type of expressive speech acts in the form of forgiveness, praise, and criticism, both types of speech acts are predominantly conducted by teachers and students; (5) speakers are always introspective in order to know exactly what the partners say or use; (6) the principle of politeness and directive type of speech applied by teachers and students in learning Indonesian, including (1) maxim of wisdom; and (2) maxim of praise; (7) directive and expressive speech action strategies used by teachers and students in learning Indonesian, directly and indirectly.
Householders’ readiness for demand-side response: A qualitative study of how domestic tasks might be shifted in time
Authors: Walker Ian , Hope Aimie
Published: February 2020

Domestic demand-side response (DSR) involves having householders shift energy-consumptive behaviours forwards or backwards in time to avoid peak-demand periods. Time of Use tariffs, which vary the cost of energy depending on when it is used, are a proposed mechanism for DSR. However, we do not know which behaviours, if any, are amenable to being brought forward or postponed, nor what information people would need to do this. Here we presented people with hypothetical variable financial costs and, for the first time, carbon costs for future energy consumption. People's think-aloud decisions about when they would perform consumptive activities were qualitatively analysed. We show that non-daily high-consumption activities (e.g., ironing, vacuuming) are perceived as moveable in response to price changes or, notably, information about environmental consequences; but barriers to moving other activities, even in the face of higher costs or environmental harm, include household dynamics (difficulties negotiating consumption across cohabitants), social roles, community living (not wishing to disturb neighbours), lack of energy literacy and the routine nature of many tasks. This study provides a framework for understanding which behaviours might or might not be shifted and what guidance and information may be needed by householders if tariffs are to provide effective DSR.
The development of simile comprehension: From comparison to scalar implicature.
Authors: Long Madeleine , Shukla Vishakha , Rubio-Fernandez Paula
Published: February 2020

Preschool children were tested on a new type of scalar implicature: saying ‘Betty is like a nurse’, normally implies that Betty is not a nurse. Experiment 1 used a guessing game with children 3, 4, 5, 6 and 13 years (N=99), who were given metaphors (‘Lucy is a parrot’) or similes (‘Lucy is like a parrot’) as clues to select one of three drawings (a parrot, a girl or a parrot-looking girl). Experiment 2 (ages 3, 4, 5 and adults; N=201) focused on the simile condition, and Experiment 3 (ages 3, 4 and 5; N=48) confirmed a similarity baseline. The results show a developmental trend in the derivation of scalar implicatures during preschool, starting as early as 3 years.
Correlations between the Hysteresis Parameters Determining the Rolling Resistance in Rubber Composites
Authors: Xu T.-W. , Jia Z.-X. , Chen Y.-J. , Jia D.-M. , Wang Y.-Q.
Published: February 2020

Recently, the research on low rolling resistance tires attracted interest for its reduction of petrol consumption, which is related to the hysteresis loss of rubber composites. Here, four common methods representing the hysteresis loss of rubber composites in lab were contrasted to explore the potential connections between them. The results indicated that tan δ obtained by DMA showed good positive linearity with that obtained by RPA without distinguishing the rubber species and filler types, also for the positive relation between tan δ and hysteresis loop area (HLA). The rolling power loss (L) captured by the rolling resistance testing machine appeared to have a positive correlation with tan δ from DMA or RPA in NR composites, while a negative connection showed up in SBR composites. Further, considering the influence of strain on rolling energy loss, the 100% modulus was introduced leading to a good positive quadratic equation connection between tan δ/100% modulus and L in all common rubber composites.
Peningkatan Daya Listrik Pada Generator Putaran Rendah Melalui Peningkatan Sifat Magnetik Magnet Permanen Bafe12o19
Authors: Andreas Kevin
Published: February 2020

AbstrakGenerator adalah suatu alat atau sistem yang dapat mengubah tenaga mekanis menjadi tenaga listrik dan menghasilkan tenaga listrik bolak-balik atau tenaga listrik searah tergantung pada tipe generator. Umumnya magnet yang digunakan pada Generator putaran rendah adalah NdFeB, yang sulit diperoleh unsur-unsur pembentuknya, maka digunakan bahan BaFe12O19 sebagai magnet alternatif. Tujuan penelitian ini adalah untuk memperoleh sifat magnetik tertinggi pada BaFe12O19 melalui variasi perlakuan sinter. Metodologi yang digunakan pada penelitian ini yaitu menggunakan metode sol-gel, dengan pengujian karakteristik serbuk yaitu permagraph,XRD dan SEM. Parameter yang digunakan yaitu pada temperatur sinter 750ºC, 800ºC dan 850ºC, masing-masing dilakukan selama 8,10,12 jam. Hasil penelitian menunjukkan bahwa untuk menghasilkan daya listrik yang tinggi pada generator dapat digunakan BaFe12O19 dengan rasio mol              Ba:Fe = 1:12 dengan kondisi temperatur sinter 850°C dan waktu sinter 12 jam. Pada kondisi tersebut dihasilkan energi magnetik terbesar (89,019 T.kA/m) dan serbuk dalam kondisi fasa tunggal (100% BaFe12O19).Kata kunci: Generator, Magnet Permanen, Metode Sol-Gel, BaFe12O19Abstract A generator is a device or system that can convert mechanical power into electric power and produce alternating electric power or electric power in the direction of the type of generator. Generally the magnet used in the low speed generator is NdFeB, which is difficult to obtain by its constituent elements, so BaFe12O19 is used as an alternative magnet. The purpose of this study was to obtain the highest magnetic properties on BaFe12O19 through variations of sintered treatment. The methodology used in this study is using the Sol-Gel Method, by testing powder characteristics, namely Permagraph, XRD and SEM. The parameters used were sintered temperatures of 750ºC, 800ºC and 850ºC, each carried out for 8,10.12 hours. The results showed that BaFe12O19 with a high mol ratio Ba: Fe = 1:12 to produce high electrical power at the generator with conditions sintered 850 ° C and sintered time 12 hours. In this condition, the largest magnetic energy (89,019 T.kA / m) and powder were produced under single phase conditions (100% BaFe12O19).Keywords: Generator, Permanent Magnet, Sol-Gel Method, BaFe12O19
Analisa Teknis Dan Biaya Penggunaan Bahan Bakar Cangkang Kelapa Sawit Dan Batu Bara Pada Boiler DZL4 Di PT. Lautan Luas Tbk.
Authors: Hartanto Laili Budi , Sibarani Maradu , Tuapetel Jones Victor
Published: February 2020

Abstrak               Boiler DZL4 dengan tipe solid fuel dioperasikan di PT. Lautan Luas Tbk untuk proses reaksi kimia. Penelitian ini bertujuan untuk menganalisa jumlah kebutuhan dan biaya untuk bahan bakar batu bara jenis bituminus dan cangkang sawit. Variabel bebas adalah kapasitas boiler 2,5 ton/jam, 3 ton/jam, 4 ton/jam. Variabel konstan adalah tekanan steam 1,25 MPa, temperatur steam 194ºC, temperature air umpan 75°C pada tekanan 0,15 MPa, efisiensi boiler 78,8%. Metode penelitian adalah dengan menghitung kebutuhan kalor boiler, kebutuhan bahan bakar, jumlah biaya untuk setiap jenis bahan bakar dilanjutkan dengan analisa. Hasil perhitungan kalor boiler kapasitas 2,5 ton/jam, 3 ton/jam, 4 ton/jam berturut-turut adalah 1.482.476 kkal/jam, 1.778.972 kkal/jam, 2.371.962 kkal/jam. Kebutuhan bahan bakar batu bara dan cangkang sawit per jam berturut-turut sebesar 304 kg, 364 kg, 483 kg dan 430 kg, 511 kg, 681 kg. Biaya untuk batu bara dan cangkang sawit per jam berturut-turut adalah Rp350.000, Rp419.000, Rp555.500, dan Rp365.500, Rp435.500, Rp579.000.Kata kunci: boiler, solid fuel, cangkang sawit, batu bara, biayaAbstract                The Boiler DZL4 with solid fuel type are operated in PT. Lautan Luas Tbk for chemical reaction processes. The purpose of this research is to analize the amount of use and costs between palm kernel shell and bituminous type of coal. The independent variables are boiler capacity of 2,5 tons/hour, 3 tons/hour and 4 tons/hour. The constant variable is steam pressure 1,25 MPa, steam temperature 194ºC, feed water temperature 75°C at 0,15 MPa pressure and boiler efficiency 78,8%. The research method is to calculate the boiler heat requirements, amount of fuel needs, the costs for each type of fuel then continue the analysis. The results of heating boiler calculations for capacity of 2,5 tons/hour, 3 tons/hour and 4 tons/hour respectively are 1.482.476 kcal/hour, 1.778.972 kcal/hour, 2.371.962 kcal/hour. The fuel consumption of coal and palm kernel shells per hour respectively are 304 kg, 364kg, 483 kg, and 430 kg, 511 kg, 681 kg. The cost for coal and palm kernel shells per hour respectively are Rp350.000, Rp419.000, Rp555.500, and Rp365.500, Rp435.500, Rp579.000.Keywords: boiler, solid fuel, palm kernel shell, coal, cost
血小板假性减少的原因分析及处理
Authors: 张 爽
Published: February 2020

随着科学技术的发展,血小板检测已经采用自动化检测技术。血小板数量减少常见于血小板减少性紫癜、再生障碍性贫血和白血病等,但在某些特殊情况下,会出现血小板检验结果的下降与实际临床不相符的情况,称之为血小板假性减少。为了提高检验结果的可靠性,为临床提供更加有效的检验结果,现对血小板假性减少原因进行分析。
Algunas claves sobre las leyes de transición energética y su posible aplicación en España
Authors: López-Tafall Bascuñana José
Published: February 2020

La necesidad de una norma de rango legal que impulse y gobierne la transición energética es un aspecto largamente contemplado en España pero que aún no se ha desarrollado. La experiencia reciente de otros países europeos, o el anuncio de una futura ley europea de cambio climático, sin duda impulsarán el debate en nuestro país.

El objetivo de este artículo es presentar una visión general de esta temática, con el objeto de ayudar al lector profano a tener un conocimiento básico de la problemática. El método empleado es analizar las razones para una ley y su posible contenido, así como aportar información sobre puntos conflictivos que, sin duda, serán objeto de discusión.

La conclusión principal es que es necesaria una ley en España que cuente con un consenso similar al que impulsó otros procesos de cambio estructural en nuestro país.
Two New Nematodes from the Families Molineidae and Strongyloididae (Nemata): Parasites of Caenolestes (Mammalia: Paucituberculata: Caenolestidae) from the Andes of Ecuador
Authors: Guerrero Ricardo
Published: February 2020

Abstract
A new genus and species of Molineinae (Nemata: Trichostrongyloidea) is described. It is similar to Molineus but differs in ray 4 being longest instead of shortest. In addition, a new species of Parastrongyloides is described that is characterized by a short digitiform appendix on the tail and spicule tips with fine points. It is the second species known with two morphotypes of the females.
Resumen
Se describe un nuevo género y especie de Molineinae (Nemata: Trichostrongyloidea). Es similar a
Molineus pero difiere en que el rayo 4 es el más largo en lugar del más corto. Además, se describe una nueva especie de Parastrongyloides que se caracteriza por un apéndice digital breve en la cola y las puntas de las espículas con puntas finas. Es la segunda especie conocida con dos morfotipos de las hembras.
تأثير الرقابة الاستراتيجية في تجنب المزالق الاستراتيجية
Authors: علي حسين الجنابي محمد حسين , عبدالله العامري بان رائد
Published: February 2020

حددت لهذه الدراسة مجالات البحث الفكري والتطبيقي في متغيرات رئيسة (الرقابة الاستراتيجية والمزالق الاستراتيجية) عبر ابعاد ومتغيرات فرعية ووجدت في ديوان الرقابة المالية الاتحادي بيئة التطبيق الملائمة كونه الاكثر عناية في مجال الرقابة بكافة انواعها, وامكانية التحليل والتفسير العلمي لما افترضته الدراسة من علاقة وتأثير واقعة بين متغيراتها بعد استرجاع (125) استمارة استبانة من اصل (148) نسخة وزعت الى قيادة هذه المؤسسة المهنية بعينة قصدية لأداراتها العليا والوسطة شملت حضوريا (%80) من حجم العينة المحدد. واستكمالا لخطوات البحث العلمي استخدمت الادوات الاحصائية والبرامج والاساليب المناسبة لتعزيز المخرجات الاساسية التي تمثلت بمجموعة استنتاجات وتوصيات من واقع العمل الرقابي وخصوصية المزالق المحتملة اسهاما في تعزيز النشاط والوظيفة الاستراتيجية كأسلوب اضافي الى انواع الرقابة المعتمدة والتكامل مع تلك الانواع, كان اهمها امكانية تجنب مزالق التنفيذ بشكل اكثر فاعلية من تأثير الرقابة الاستراتيجية في الابعاد الاخرى للمزالق والتي خضعت للدراسة.
تأثير الاحتراق الوظيفي في اداء العاملين : بحث ميداني في الشركة العامة لصناعة الزيوت النباتية
Authors: علي العزاوي شفاء محمد , عبدالله ساره لعيبي
Published: February 2020

يهدف هذا البحث الى معرفه تأثير الاحتراق الوظيفي في أداء العاملين. فقد قدمت الباحثة اساسا نظريا عن الاحتراق الوظيفي واداء العاملين ولغرض تحقيق اهداف البحث تم بناء مخطط فرضي يحدد طبيعة العلاقة بين المتغير المستقل المتمثل بالاحتراق الوظيفي بأبعاده (الانهاك الوظيفي، تدني الانجاز الشخصي، تبلد المشاعر) والمتغير المعتمد أداء العاملين بأبعاده (الإنتاجية، الرضا الوظيفي، الالتزام التنظيمي، الابداع)،  وللتعرف على طبيعة العلاقة بين المتغيرات اعتمد البحث مجموعه من الفرضيات الرئيسة والفرعية المنبثقة منها.  ولغرض اختبار فرضيات البحث فقد تم تطبيق البحث على عينه من العاملين في الشركة العامة لصناعه الزيوت النباتية لغرض الحصول على المعلومات اللازمة من خلال استمارة استبانة اعدت لهذا الغرض ولقد بلغ حجم المجتمع بحسب ٳِحصائيات المنظمة ( 130 ) فرداً , وتم تحديد حجم العينة من هذا المجتمع بحسب أنموذج (دي موركان , D.Morgan) العالمي ; لتحديد حجم العينة عند مستوى دلالة ( 0.05 ) , ولغاية (0.01) , ٳذ بلغ حجم العينة  بحسب هذا الأنموذج  (97) فرداً أي بنسبة (75 %) من ٳِجمالي مجتمع البحث يمثلون المستويات الإدارية الوسطى والدنيا لمختلف الاقسام واستعملت مجموعه من الوسائل الإحصائية كالتكرار النسبي والوسط الحسابي والانحراف المعياري ومعامل الاختلاف لقياس وتحليل اراء عينه البحث ومعامل الارتباط البسيط بيرسون لقياس علاقه الارتباط بين المتغيرات واختبارt) ) لمعرفه معنويه علاقه الارتباط البسيط وتحليل الانحدار المتعدد  وقد توصل البحث الى مجموعه من الاستنتاجات كان اهمها ان وجود الاحتراق الوظيفي في الشركة يساهم بانخفاض مستويات الاداء الوظيفي أي وجود علاقة ارتباط عكسية قوية بين الاحتراق الوظيفي والإنتاجية، واتضح ان متغير تلبد المشاعر اقوى الابعاد بعدم وجود أي ارتباط وتأثير بينه وبين الاداء اضافه الى ذلك قدمت الباحثة مجموعه توصيات كان اهمها الحد من ظاهره الاحتراق الوظيفي والعمل على وضع معالجات وقائية تفيد الشركة المبحوثة.
Perindoprilat Changes ANG (1-9) Production in Renal Arteries Isolated From Young Spontaneously Hypertensive Rats After ANG I Incubation
Authors: WOŁKOW P. P. , BUJAK-GIŻYCKA B. , JAWIEŃ J. , OLSZANECKI R. , MADEJ J. , RUTOWSKI J. , KORBUT R.
Published: February 2020

We used mass spectrometry to quantitate production of angiotensinogen metabolites in renal artery of 3- and 7-month-old Wistar-Kyoto (WKY) and Spontaneously Hypertensive Rats (SHR). Tissue fragments were incubated for 15 min in oxygenated buffer, with added angiotensin I. Concentrations of angiotensins I (ANG I), II (ANG II), III (ANG III), IV (ANG IV), angiotensin (1-9) [ANG (1-9)], angiotensin (1-7) [ANG (1-7)], and angiotensin (1-5) [ANG (1-5)], excreted into the buffer during experiment, were measured using liquid chromatography-mass spectrometry (LC/MS) and expressed per mg of dry tissue. Effects of pretreatment with 10 μM perindoprilat on the production of ANG I metabolites were quantitated. Background production of any of ANG I metabolites differed neither between WKY and SHR rats nor between 3- and 7-month-old rats. Perindoprilat pretreatment of renal arteries resulted, as expected, in decrease of ANG II production. However, renal arteries of 7-month-old SHR rats were resistant to ACE inhibitor and did not change ANG II production in response to perindoprilat. In renal arteries, taken from 3-month-old rats, pretreated with perindoprilat, incubation with ANG I, resulted in the level of ANG (1-9) significantly higher in SHR than WKY rats. Our conclusion is that in SHR rats, sensitivity of renal artery ACE to perindoprilat inhibition changes with age.
Optimasi Prediksi Penyakit Systemic Lupus Erythematosus Menggunakan Algoritma Particle Swarm Optimization
Authors: Putri Ramalia Noratama , Setiawan Debi
Published: February 2020

Systemic lupus erythematosus (SLE) juga dikenal sebagai lupus, adalah penyakit autoimun di mana sistem kekebalan tubuh secara keliru menyerang jaringan sehat di banyak bagian tubuh. Jumlah penderita SLE semakin meningkat tiap tahun. Systemic Lupus Erythematosus telah diderita sebanyak lima juta orang diseluruh dunia. Penderita SLE di China lebih tinggi dari negara Eropa dan Amerika Utara, perkiraan prevalensi SLE adalah 50-100 kasus per 100.000 orang. Sedangkan di Indonesia, berdasarkan Sistem Inormasi Rumah Sakit Online (SIRS Online) pada tahun 2014 terdapat 1.169 penderita SLE, tahun 2015 terdapat 1.336 penderita SLE, dan tahun 2016 terdapat 2.116, dari data tersebut terlihat peningkatan angka penderita SLE setiap tahun. Salah satu penyebab dari tingginya angka penderita penyakit SLE adalah sulitnya mendiagnosa penyakit SLE. Tantangan terbesar dalam ilmu kedokteran adalah bagaimana melakukan deteksi dini dalam mendiagnosa penyakit SLE. Deteksi dini dalam diagnosa penyakit SLE dapat dilakukan dengan prediksi penyakit SLE. Penelitian ini melakukan optimasi terhadap hasil prediksi penyakit SLE dengan metode genetika. Metode optimasi yang digunakan adalah algoritma particle swarm optimization. Hasil dari penelitian adalah algoritma particle swarm optimization dapat melakukan optimasi dengan 6 pasien teridentifikasi secara tepat. Akurasi dari optimasi adalah 88 %.
Moringin, A Stable Isothiocyanate from Moringa oleifera, Activates the Somatosensory and Pain Receptor TRPA1 Channel In Vitro
Authors: Borgonovo Gigliola , De Petrocellis Luciano , Schiano Moriello Aniello , Bertoli Simona , Leone Alessandro , Battezzati Alberto , Mazzini Stefania , Bassoli Angela
Published: February 2020

Moringa oleifera Lam. is a tropical plant widely used in traditional medicines and as a food supplement. It is characterized by the presence of glucosinolates and isothiocyanates; the stable isothiocyanate 4-[(α-l-rhamnosyloxy)benzyl]isothiocyanate (moringin) has been widely studied for its bioactivity as hypoglycemic, antimicrobial, anticancer and in particular for its involvement in nociception and neurogenic pain. Moringa extracts and pure moringin were submitted to in vitro assays with the somatosensory TRPA1 ion channel, proving that moringin is a potent and effective agonist of this receptor involved in nociceptive function and pain states. Moringin do not activate or activates very weakly the vanilloids somatosensory channels TRPV1,2,3 and 4, and the melastatin cooling receptor TRPM8. The comparison of moringin’s activity with other known agonists of natural origin is also discussed.
Phytochemical Characterization and Chemotherapeutic Potential of Cinnamomum verum Extracts on the Multiplication of Protozoan Parasites In Vitro and In Vivo
Authors: Batiha Gaber El-Saber , Beshbishy Amany Magdy , Guswanto Azirwan , Nugraha Arifin , Munkhjargal Tserendorj , M. Abdel-Daim Mohamed , Mosqueda Juan , Igarashi Ikuo
Published: February 2020

Cinnamomum verum is a commonly used herbal plant that has several documented properties against various diseases. The existing study evaluated the inhibitory effect of acetonic extract of C. verum (AECV) and ethyl acetate extract of C. verum (EAECV) against piroplasm parasites in vitro and in vivo. The drug-exposure viability assay was tested on Madin-Darby bovine kidney (MDBK), mouse embryonic fibroblast (NIH/3T3) and human foreskin fibroblast (HFF) cells. Qualitative phytochemical estimation revealed that AECV and EAECV containing multiple bioactive constituents namely alkaloids, tannins, saponins, terpenoids and remarkable amounts of polyphenols and flavonoids. AECV and EAECV inhibited B. bovis, B. bigemina, B. divergens, B. caballi, and T. equi multiplication at half-maximal inhibitory concentrations (IC50) of 23.1 ± 1.4, 56.6 ± 9.1, 33.4 ± 2.1, 40.3 ± 7.5, 18.8 ± 1.6 µg/mL, and 40.1 ± 8.5, 55.6 ± 1.1, 45.7 ± 1.9, 50.2 ± 6.2, and 61.5 ± 5.2 µg/mL, respectively. In the cytotoxicity assay, AECV and EAECV affected the viability of MDBK, NIH/3T3 and HFF cells with half-maximum effective concentrations (EC50) of 440 ± 10.6, 816 ± 12.7 and 914 ± 12.2 µg/mL and 376 ± 11.2, 610 ± 7.7 and 790 ± 12.4 µg/mL, respectively. The in vivo experiment showed that AECV and EAECV were effective against B. microti in mice at 150 mg/kg. These results showed that C. verum extracts are potential antipiroplasm drugs after further studies in some clinical cases.
Direct Base-Assisted C‒H Cyclonickelation of 6-Phenyl-2,2′-bipyridine
Authors: Vogt Nicolas , Sivchik Vasily , Sandleben Aaron , Hörner Gerald , Klein Axel
Published: February 2020

The organonickel complexes [Ni(Phbpy)X] (X = Br, OAc, CN) were obtained for the first time in a direct base-assisted arene C(sp2)–H cyclometalation reaction from the rather unreactive precursor materials NiX2 and HPhbpy (6-phenyl-2,2′-bipyridine) or from the versatile precursor [Ni(HPhbpy)Br2]2. Different from previously necessary C‒Br oxidative addition at Ni(0), an extended scan of reaction conditions allowed quantitative access to the title compound from Ni(II) on synthetically useful timescales through base-assisted C‒H activation in nonpolar media at elevated temperature. Optimisation of the reaction conditions (various bases, solvents, methods) identified 1:2 mixtures of acetate and carbonate as unrivalled synergetic base pairs in the optimum protocol that holds promise as a readily usable and easily tuneable access to a wide range of direct nickelation products. While for the base-assisted C‒H metalation of the noble metals Ru, Ir, Rh, or Pd, this acetate/carbonate method has been established for a few years, our study represents the leap into the world of the base metals of the 3d series.
Biological and Spectroscopic Investigations of New Tenoxicam and 1.10-Phenthroline Metal Complexes
Authors: Elshafie Hazem , Sadeek Sadeek , Camele Ippolito , Awad Hanem , Mohamed Amira
Published: February 2020

In the present work, tenoxicam (H2Ten) reacted with Mn(II), Co(II), Ni(II), Cu(II) and Zn (II) ions in the presence of 1.10-phenthroline (Phen), forming new mixed ligand metal complexes. The properties of the formed complexes were depicted by elemental analyses, infrared, electronic spectra, proton nuclear magnetic resonance (1H NMR), mass spectrometry, thermogravimetric (TGA) and differential thermogravimetric (DTG) analysis, molar conductance and magnetic moment. IR spectra demonstrated that H2Ten acted as a neutral bidentate ligand, coordinated to the metal ions via the pyridine-N and carbonyl group of the amide moiety, and Phen through the nitrogen atoms. Kinetic thermodynamics parameters activation energy (E*), enthalpy of activation (ΔH*), entropy of activation (ΔS*), Gibbs, free energy (ΔG*) associated to the complexes have been evaluated. Antibacterial screening of the compounds was carried out in vitro against Clavibacter michiganensis, Xanthomonas campestris and Bacillus megaterium. Antifungal activity was performed in vitro against Monilinia fructicola, Penicillium digitatum and Colletotrichum acutatum. The possible phytotoxic effect of the studied compounds was also investigated on Solanum lycopersicum (tomatoes) and Lepidium sativum (garden cress) seeds. The anticancer activity was screened against cell cultures of HCT-116 (human colorectal carcinoma), HepG2 (human hepatocellular carcinoma) and MCF-7 (human breast adenocarcinoma).
Poultry Farms as a Potential Source of Environmental Pollution by Pharmaceuticals
Authors: Wychodnik Katarzyna , Gałęzowska Grażyna , Rogowska Justyna , Potrykus Marta , Plenis Alina , Wolska Lidia
Published: February 2020

Industrial poultry breeding is associated with the need to increase productivity while maintaining low meat prices. Little is known about its impact on the environment of soil pollution by pharmaceuticals. Breeders routinely use veterinary pharmaceuticals for therapeutic and preventive purposes. The aim of this work was to determine the influence of mass breeding of hens on the soil contamination with 26 pharmaceuticals and caffeine. During two seasons—winter and summer 2019—15 soil samples were collected. Liquid extraction was used to isolate analytes from samples. Extracts were analyzed using ultra-high performance liquid chromatography coupled with tandem mass spectrometry detection (UPLC-MS/MS). The results showed the seasonal changes in pharmaceutical presence in analyzed soil samples. Ten pharmaceuticals (metoclopramide, sulphanilamide, salicic acid, metoprolol, sulphamethazine, nimesulide, carbamazepine, trimethoprim, propranolol, and paracetamol) and caffeine were determined in soil samples collected in March, and five pharmaceuticals (metoclopramide, sulphanilamide, sulphamethazine, carbamazepine, sulfanilamid) in soil samples collected in July. The highest concentrations were observed for sulphanilamide, in a range from 746.57 ± 15.61 ng/g d.w to 3518.22 ± 146.05 ng/g d.w. The level of bacterial resistance to antibiotics did not differ between samples coming from intensive breeding farm surroundings and the reference area, based on antibiotic resistance of 85 random bacterial isolates.
Sulfonamide Inhibition Studies of the β-Class Carbonic Anhydrase CAS3 from the Filamentous Ascomycete Sordaria macrospora
Authors: Vullo Daniela , Lehneck Ronny , Donald William A. , Pöggeler Stefanie , Supuran Claudiu T.
Published: February 2020

A new β-class carbonic anhydrase was cloned and purified from the filamentous ascomycete Sordaria macrospora, CAS3. This enzyme has a higher catalytic activity compared to the other two such enzymes from this fungus, CAS1 and CAS2, which were reported earlier, with the following kinetic parameters: kcat of (7.9 ± 0.2) × 105 s−1, and kcat/Km of (9.5 ± 0.12) × 107 M−1∙s−1. An inhibition study with a panel of sulfonamides and one sulfamate was also performed. The most effective CAS3 inhibitors were benzolamide, brinzolamide, dichlorophnamide, methazolamide, acetazolamide, ethoxzolamide, sulfanilamide, methanilamide, and benzene-1,3-disulfonamide, with KIs in the range of 54–95 nM. CAS3 generally shows a higher affinity for this class of inhibitors compared to CAS1 and CAS2. As S. macrospora is a model organism for the study of fruiting body development in fungi, these data may be useful for developing antifungal compounds based on CA inhibition.
Ceiba speciosa (A. St.-Hil.) Seeds Oil: Fatty Acids Profiling by GC-MS and NMR and Bioactivity
Authors: Rosselli Sergio , Tundis Rosa , Bruno Maurizio , Leporini Mariarosaria , Falco Tiziana , Gagliano Candela Rossella , Badalamenti Natale , Loizzo Monica R.
Published: February 2020

This study aimed to evaluate the chemical composition by gas chromatography-mass spectrometry (GC-MS) and Nuclear Magnetic Resonance (NMR) analyses, the antioxidant activities evaluated by different in vitro assays namely 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), Ferric Reducing Ability Power (FRAP), and β-carotene bleaching tests, and the inhibitory effects of enzymes linked to obesity (lipase, α-amylase, and α-glucosidase) of fixed seed oil of Ceiba speciosa (A. St.-Hil.). Fourteen compounds were identified. Linoleic acid (28.22%) was the most abundant followed by palmitic acid (19.56%). Malvalic acid (16.15%), sterculic acid (11.11%), and dihydrosterculic acid (2.74%) were also detected. C. speciosa fixed oil exerted a promising ABTS radicals scavenging activity with an IC50 value of 10.21 µg/mL, whereas an IC50 of 77.44 µg/mL against DPPH+ radicals was found. C. speciosa fixed oil inhibited lipase with an IC50 value of 127.57 µg/mL. The present investigation confirmed the functional properties of C. speciosa fixed oil, and proposes its use as valuable source of bioactive constituents.
Antimicrobial, Antioxidant, and Anticancer Activities of Some Novel Isoxazole Ring Containing Chalcone and Dihydropyrazole Derivatives
Authors: Shaik Afzal , Bhandare Richie R. , Palleapati Kishor , Nissankararao Srinath , Kancharlapalli Venkata , Shaik Shahanaaz
Published: February 2020

Our previous work identified isoxazole-based chalcones and their dihydropyrazole derivatives as two important five-membered heterocycles having antitubercular activity. Hence, in the present study, we biologically evaluated 30 compounds, including 15 isoxazole ring-containing chalcones (17–31) and 15 dihydropyrazoles (32–46) derived from these chalcones for their antimicrobial, antioxidant, and anticancer activities. Chalcones exhibited superior antibacterial and antioxidant activities compared to dihydropyrazoles. Among the chalcones, compound 28 showed potent antibacterial (MIC = 1 µg/mL) and antioxidant activities (IC50 = 5 ± 1 µg/mL). Dihydropyrazoles, on the contrary, demonstrated remarkable antifungal and anticancer activities. Compound 46 (IC50 = 2 ± 1 µg/mL) showed excellent antifungal activity whereas two other dihydropyrazoles 45 (IC50 = 2 ± 1 µg/mL) and 39 (IC50 = 4 ± 1 µg/mL) exhibited potential anticancer activity. The compounds were also tested for their toxicity on normal human cell lines (LO2) and were found to be nontoxic. The active compounds that have emerged out of this study are potential lead molecules for the development of novel drugs against infectious diseases, oxidative stress, and cancer.
Cu(II) Ion Adsorption by Aniline Grafted Chitosan and Its Responsive Fluorescence Properties
Authors: Vafakish Bahareh , Wilson Lee D.
Published: February 2020

The detection and removal of heavy metal species in aquatic environments is of continued interest to address ongoing efforts in water security. This study was focused on the preparation and characterization of aniline grafted chitosan (CS-Ac-An), and evaluation of its adsorption properties with Cu(II) under variable conditions. Materials characterization provides support for the grafting of aniline onto chitosan, where the kinetic and thermodynamic adsorption properties reveal a notably greater uptake (>20-fold) of Cu(II) relative to chitosan, where the adsorption capacity (Qm) of CS-Ac-An was 106.6 mg/g. Adsorbent regeneration was demonstrated over multiple adsorption-desorption cycles with good uptake efficiency. CS-Ac-An has a strong fluorescence emission that undergoes prominent quenching at part per billion levels in aqueous solution. The quenching process displays a linear response over variable Cu(II) concentration (0.05–5 mM) that affords reliable detection of low level Cu(II) levels by an in situ “turn-off” process. The tweezer-like chelation properties of CS-Ac-An with Cu(II) was characterized by complementary spectroscopic methods: IR, NMR, X-ray photoelectron (XPS), and scanning electron microscopy (SEM). The role of synergistic effects are inferred among two types of active adsorption sites: electron rich arene rings and amine groups of chitosan with Cu(II) species to afford a tweezer-like binding modality.
Quercetin Protects against Lipopolysaccharide-Induced Intestinal Oxidative Stress in Broiler Chickens through Activation of Nrf2 Pathway
Authors: Sun Lei , Xu Gaoqing , Dong Yangyunyi , Li Meng , Yang Lianyu , Lu Wenfa
Published: February 2020

We investigated the potential ability of quercetin to protect against lipopolysaccharide (LPS)-induced intestinal oxidative stress in broiler chickens and the potential role of the Nrf2 (nuclear factor erythroid 2-related factor 2) signaling pathway. One-day-old broiler chickens (n = 240) were randomized into four groups: saline-challenged broiler chickens fed a basal diet (Con), LPS-challenged broiler chickens on a basal diet (LPS), and LPS-treated broiler chickens on a basal diet containing either 200 or 500 mg/kg of quercetin (Que200+LPS or Que500+LPS). Quercetin (200 mg/kg) significantly alleviated LPS-induced decreased duodenal, jejunal, and illeal villus height and increased the crypt depth in these regions. Quercetin significantly inhibited LPS-induced jejunal oxidative stress, including downregulated reactive oxygen species (ROS), malondialdehyde (MDA), and 8-hydroxy-2′-deoxyguanosine (8-OHdG) levels, and it upregulated superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) levels. Quercetin relieved LPS-induced jejunal mitochondria damage and upregulated mitochondrial DNA copy number-related gene expression, including cytochrome c oxidase subunit 1 (COX1), ATP synthase F0 subunit 6 (ATP6), and NADH dehydrogenase subunit 1 (ND1). Quercetin attenuated the LPS-induced inhibition of Nrf2 activation, translocation, and downstream gene expression, including heme oxygenase-1 (HO-1), NAD (P) H dehydrogenase quinone 1 (NQO1), and manganese superoxide dismutase (SOD2). Additionally, quercetin attenuated the LPS-inhibition of c-Jun N-terminal kinase (JNK), Extracellular Regulated protein Kinases (ERK), and p38MAPK (p38) phosphorylation in the MAPK pathway. Thus, quercetin attenuated LPS-induced oxidative stress in the intestines of broiler chickens via the MAPK/Nrf2 signaling pathway.
Hybridisation and introgression in British Helosciadium (Apiaceae).
Authors: Desjardins Stuart D. , Shaw Andrew G. , Webb Judith A.
Published: February 2020

Reticulation between Helosciadium repens (Jacq.) W.D.J. Koch and H. nodiflorum (L.) W.D.J. Koch (Apiaceae) has been the source of much speculation, but until now supporting evidence has remained largely anecdotal. In the current study inter-specific hybridisation and introgression between the two species was confirmed using DNA barcoding. The parentage of three putative hybrids collected from Port Meadow, Oxfordshire (UK) was determined using a maternally-inherited chloroplast marker (rps16-trnK) and two biparentally-inherited nuclear markers (LEAFYi2, ITS). Two of the individuals are early-generation hybrids between H. repens and H. nodiflorum, F1 or otherwise, while the third is most likely a backcross to H. repens. These individuals are the first confirmed hybrids/hybrid derivatives between the two parental species, and represent a new addition to the British flora. The hybrids closely resemble H. nodiflorum var. longipedunculatum F.W. Schultz, and in our view should be treated as H. × longipedunculatum (F.W. Schultz) Desjardins.