bluuebunny/crossref_metadata_2025 huggingface dataset:
Coordinated Action of NRPS, Baeyer-Villiger Monooxygenase, and Methyltransferase Ensures the Economical Biosynthesis of Bohemamines in Streptomyces sp. CB02009
Authors: Liu Ling , Li Sainan , Sun Runze , Qin Xiangjing , Ju Jianhua , Zhang Changsheng , Duan Yanwen , Huang Yong
Published: February 2020

Bohemamines (BHMs) are bacterial alkaloids containing a pyrrolizidine core with two unprecedented methyl groups. Herein we report the activation of BHMs biosynthesis in Streptomyces sp. CB02009 using a ribosome engineering approach. Identification and characterization of the bhm gene cluster reveals a coordinated action of nonribosomal peptide synthetase BhmJ, Baeyer-villiger monooxygenase BhmK and methyltransferase BhmG for BHMs biosynthesis. BhmG is responsible for the C-methylation on C-7, while the C-9 methyl group is from a non-proteinogenic amino acid (2S,5S)-5-methylproline, required for BHMs production in three model Streptomyces hosts. Our study shed light on the intricate interaction of BhmJ/BhmK/BhmG for the economical biosynthesis of BHMs in their native producer, and also unraveled that BhmJ and BhmK are competent biocatalysts in Streptomyce albus.
Multiplexed Online-Monitoring of Microfluidic Free-Flow Electrophoresis via Mass Spectrometry
Authors: Jender Matthias , Novo Pedro , Maehler Dominic , Münchberg Ute , Janasek Dirk , Freier Erik
Published: February 2020

Free-flow electrophoresis is a tool for the continuous fractionation of electrically charged analytes. In this study we introduce a novel method to couple microchip-based free-flow electrophoresis with mass spectrometry. The successive connection of multiple microchip outlets to the electrospray ionization source of a mass spectrometer is automated using a multiposition valve. With this novel setup it is possible to continuously fractionate and collect compounds while simultaneously monitoring the process online with mass spectrometry. The functionality of the method is demonstrated by the successful separation and identification of the biomolecules AMP, ATP and CoA, which are fundamental for numerous biochemical processes in every organism.
Structure-Activity Relationship Studies of Retro-1 Analogues Against Shiga Toxin
Authors: Abdelkafi Hajer , Michau Aurélien , Pons Valérie , Ngadjeua Flora , Clerget Alexandra , Ait Ouarab Lilia , Buisson David-Alexandre , Caramelle Lucie , Gillet Daniel , Barbier Julien , Cintrat Jean-Christophe
Published: February 2020

The Retro-1 molecule was identified in a high-throughput screening as an inhibitor of ricin and Shiga toxins by diminishing their intracellular trafficking via the retrograde route, from early endosomes to the Golgi apparatus. In order to improve the activity of Retro-1, a SAR study was undertaken yielding an analog that possesses roughly 70-fold better EC50 against Shiga toxin cytotoxicity measured in a cell protein synthesis assay.
An Intelligent AIEgen with Nonmonotonic Multi-Responses to Multi-Stimuli
Authors: Tu Yujie , Yu Yeqing , Xiao Diwen , Liu Junkai , zhao zheng , liu zhiyang , Lam Jacky W. Y. , Tang Ben Zhong
Published: February 2020

Intelligent stimulus-response (S/R) systems are the basis of natural process and machine control, and have been intensively explored in biomimetic design, analytical chemistry and biological applications. However, nonmonotonic multi-S/R systems are still rarely studied so far. Now, we propose a rational design strategy to achieve such a unique S/R system by integrating opposite luminescence behaviors in one molecule. When solvent polarity increases, many heterocycles often become more emissive due to the suppression of the proximity effect. However, molecules with donor-acceptor (D-A) structures tend to be less emissive because of the twisted intramolecular charge transfer. Meanwhile, protonation on D/A moieties will weaken/strengthen the D-A interaction to result in blue/red-shifted emissions. By combining a protonatable heterocyclic acceptor and a protonatable donor together in one molecule, we can easily achieve nonmonotonic brightness responses to polarity stimuli and nonmonotonic color responses to pH stimuli. In this work, a simple molecule, namely ASQ is chosen as the model compound to verify the design strategy feasibility. It successfully shows two opposite trends of responses to polarity and pH stimuli, and aggregation-induced emission (AIE) with a nonmonotonic AIE curve. Moreover, the acidified ASQ solution is also a pure organic up-conversion and white-light-emitting system. A new mechanistic viewpoint is established to explain its unique anti-Stokes emission. Besides, ASQ shows multivalent functionalities including albumin protein sensing, ratiometric pH sensing, and amine gas sensing, etc. Therefore, ASQ is proved to be a fundamentally important and versatile functional “intelligent” AIE luminogen with nonmonotonic multi-responses to multi-stimuli.
Advancement of Actinide Metal-Organic Framework Chemistry via Synthesis of Pu-UiO-66
Authors: Hastings Ashley , Ray Debmalya , Jeong WooSeok , Gagliardi Laura , Farha Omar K. , Hixon Amy
Published: February 2020

We report the synthesis and characterization of the first plutonium metal-organic framework (MOF). Pu-UiO-66 expands the established UiO-66 series, which includes transition-metal, lanthanide, and early actinide elements in the hexanuclear nodes. The thermal stability and porosity of Pu-UiO-66 were experimentally determined and multi-faceted computational methods were used to corroborate experimental values, examine inherent defects in the framework and decipher spectroscopic signatures. The crystallization of a plutonium chain side product provides direct evidence of the competition that occurs between modulator and linker in MOF syntheses. Ultimately, the synthesis of Pu-UiO-66 demonstrates adept control of Pu(IV) coordination under hydrolysis-prone conditions, provides an opportunity to extend trends across isostructural UiO-66 frameworks and serves as the foundation for future plutonium MOF chemistry.
Antimicrobial Activity of Iron-Halide Complexes Against Gram-Positive and Gram-Negative Bacteria
Authors: Abedin Nusrat , Alshehri Abdullah Hamed A , Almughrbi Ali M A , Moore Olivia , Alyza Sheikh , Rusbridge Elizabeth , Masood Naqash , Egbowon Biola , Hargreaves Alan J. , Fitzpatrick Anthony , Dafhnis-Calas Felix
Published: February 2020

Antimicrobial resistance (AMR) has become one of the more serious threats to the global health. The emergence of bacteria resistant to antimicrobial substances decreases the potencies of current antibiotics. Consequently, there is an urgent and growing need for the developing of new classes of antibiotics. Three prepared novel iron complexes have a broad-spectrum antimicrobial activity with minimum bactericidal concentration (MBC) values ranging from 3.5 to 10 mM and 3.5 to 40 mM against Gram-positive and Gram-negative bacteria with antimicrobial resistance phenotype, respectively. Time-kill studies and quantification of the extracellular DNA confirmed the bacteriolytic mode of action of the iron-halide compounds. Additionally, the novel complexes showed significant antibiofilm activity against the tested pathogenic bacterial strains at concentrations lower than the MBC. The cytotoxic effect of the complexes on different mammalian cell lines show sub-cytotoxic values at concentrations lower than the minimum bactericidal concentrations.
Regioselective Mono and Homo/hetero Dihalogenation of the Benzothioxanthene Monoimide
Authors: Dalinot Clement , Simon Marques Pablo , Andrés Castán Jose Maria , Josse Pierre , Allain Magali , Abad Galan Laura , Monnereau Cyrille , MAURY Olivier , Blanchard Philippe , Cabanetos Clement
Published: February 2020

Through the preparation and characterization of five new derivatives, the regioselective mono and di, homo and hetero, halogenation of the benzothioxanthene (BTXI) core is demonstrated herein. All structurally solved by X-ray crystallography, these complementary functionalized building blocks open doors to the design of new symmetrical and asymmetrical π-conjugated systems based on this promising but still under-explored rylene.
Wrinkling Poly(trimethylene 2,5-Furanoate) Free-standing Films: Nanostructure Formation and Physical Properties
Authors: Soccio Michelina , Lotti Nadia , Munari Andrea , Rebollar Esther , Martínez-Tong Daniel E
Published: February 2020

Nanostructured wrinkles were developed on fully bio-based poly(trimethylene furanoate) (PTF) films by using the technique of Laser Induced Periodic Surface Structures (LIPSS). We investigated the effect of irradiation time on wrinkle formation using an UV pulsed laser source, at a fluence of 8 mJ/cm2. It was found that the pulse range between 600 and 4800 pulses allowed formation of periodic nanometric ripples. The nanostructured surface was studied using a combined macro- and nanoscale approach. We evaluated possible physicochemical changes taking place on the polymer surface after irradiation by infrared spectroscopy, contact angle measurements and atomic force microscopy. The macroscopic physicochemical properties of PTF showed almost no changes after nanostructure formation, differently from the results previously found for the terephthalic counterparts, as poly(ethyleneterephthalate), PET, and poly(trimethyleneterephthalate), PTT. The surface mechanical properties of the nanostructured PTF were found to be improved, as evidenced by nanomechanical force spectroscopy measurements. In particular, an increased Young’s modulus and higher stiffness for the nanostructured sample were measured.
Repurposing Therapeutics for the Wuhan Coronavirus nCov-2019: Supercomputer-Based Docking to the Viral S Protein and Human ACE2 Interface
Authors: Smith Micholas , Smith Jeremy C.
Published: February 2020

The novel Wuhan coronavirus (nCov-2019) has been sequenced, and the virus shares substantial similarity with SARS-CoV. Here, using a computational model of the spike protein (S-protein) nCov-2019 interacting with the human ACE2 receptor, we make use of the world's most powerful supercomputer, SUMMIT, to enact an ensemble docking virtual high-throughput screening campaign and identify small-molecules which may be repurposed to disrupt host-virus interactions. A ranked list of compounds is given that can be tested experimentally.
Catalytic Synthesis of 8-Membered Ring Compounds via Cobalt(III)-Carbene Radicals
Authors: Zhou M. , van der Vlugt J.I. , de Bruin Bas
Published: February 2020

The metalloradical activation of o-aryl aldehydes with cobalt(II) porphyrin complexes as catalysts produces cobalt(III)-carbene radical intermediates, providing a novel and powerful strategy for the synthesis of medium-sized ring structures. Herein we make use of the intrinsic radical-type reactivity of cobalt(III)-carbene radical intermediates in the [CoII(TPP)]-catalyzed (TPP = tetraphenylporphyrin) synthesis of two types of 8 membered ring compounds; novel dibenzocyclooctenes and unique monobenzo-cyclooctadienes. The method was successfully applied to a variety of substrates, producing several 8-membered ring compounds in good yields and with excellent substituent tolerance. DFT calculations and experimental results suggest that the reactions proceed via initial hydrogen atom transfer from the bis-allylic/benzallylic C-H bond to the carbene radical moiety, followed by two divergent processes for ring-closure to the two different types of 8-membered ring products. While the dibenzocyclooctenes are formed by dissociation of o quinodimethanes (o-QDMs) from the catalyst that undergo an uncatalyzed ring-closure reaction involving 8-pi-cyclisation, DFT calculations suggest that ring-closure to the monobenzocyclooctadienes involves a radical-rebound step in the coordination sphere of cobalt. The latter mechanism implies that unprecedented enantioselective ring-closure reactions to chiral benzocyclooctadienes should be possible, as was confirmed for reactions mediated by a chiral cobalt-porphyrin catalyst.
Mwfn: A Strict, Concise and Extensible Format for Electronic Wavefunction Storage and Exchange
Authors: Lu Tian , Chen Qinxue
Published: February 2020

Analysis of electronic wavefunction generated by quantum chemistry codes has crucial role in exploring nature of electronic structure and providing valuable information of chemical interest. A file containing wavefunction information is inevitably needed as a communicator between wavefunction analysis codes and quantum chemistry programs. There have been many available formats designed for recording wavefunction, such as .fch, .molden, .wfn, .wfx and so on, however they all have different flaws and thus bringing evident inconvenience for development of new wavefunction analysis codes. To overcome this problem, in this article we define a new format "mwfn" (acronym of "Multiwfn wavefunction file") for electronic wavefunction storage and exchange purposes. This format is strict, concise, extensible, and able to provide all kinds of information for common wavefunction analyses. Since the "mwfn" format fully eliminates all shortcomings of existing formats, we expect it will become a standard for recording wavefunction in the field of wavefunction analysis and quantum chemistry.
Development of an Efficient and Sustainable Synthesis of 2-(3-Methyl-1H-1,2,4-Triazol-1-Yl) Acetic Acid Under Continuous-Flow Conditions
Authors: Tortoioli Simone , Friedli Astrid , Prud’homme Alice , Richard-Bildstein Sylvia , Kohler Philipp , Abele Stefan , Vilé Gianvito
Published: February 2020

A novel, metal-free process for the challenging synthesis of 2-(3-methyl-1H-1,2,4-triazol-1-yl) acetic acid (1) is reported, which features an efficient condensation for the triazole build-up under flow conditions. This continuous, two-step method is atom economical, highly selective and environmentally benign, due to the avoidance of chromatography and isolation steps. Compared to the earlier batch synthetic routes, higher yields were achieved in a flow reactor. In addition, a highly energetic intermediate could be controlled and handled in a safe manner. To generalize the established route, several triazoles were finally prepared under the described conditions, confirming that the methodology could find useful applications for the rapid and sustainable construction of differentially functionalized 1,2,4-triazoles.
Hubungan spiritualitas dan sensitivitas moral mahasiswa keperawatan
Authors: Ariawan I Gede Nova , Suastrawan Putu Gede Putra , Yanti Ni Putu Emy Darma
Published: February 2020

Spiritualitas sebagai sebuah keyakinan seringkali dikaitkan dengan hubungan transenden yang berdampak pada sikap dan perilaku individu, salah satunya sensitivitas moral dalam keperawatan. Sensitivitias moral merupakan ketentuan penting dalam praktik keperawatan dan menjadi tuntutan dalam memberikan pelayanan kesehatan secara holistik. Tujuan penelitian ini untuk mengidentifikasi hubungan spiritualitas dan sensitivitas moral mahasiswa keperawatan di Provinsi Bali. Penelitian kuantitatif dengan rancangan deskriptif korelasional ini mengikutsertakan 122 mahasiswa keperawatan di Bali sebagai sampel dan menggunakan teknik purposive sampling. Data dikumpulkan dengan menggunakan kuesioner data demografi, spiritualitas, dan sensitivitas moral. Penelitian ini memperoleh hasil bahwa terdapat hubungan antara spiritualitas dengan sensitvitas moral mahasiswa keperawatan di Provinsi Bali (r = 0.320, P<0,001). Hasil ini menunjukkan bahwa adanya hubungan yang lemah antara kedua variabel dengan arah hubungan yang positif dengan makna semakin tinggi tingkat spiritualitas mahasiswa keperawatan maka semakin tinggi sensitivitas moral mahasiswa keperawatan. Faktor-faktor lain yang dapat memengaruhi sensitivitas moral mahasiswa keperawatan perlu diteliti lebih lanjut. Kata kunci: spiritualitas, sensitivitas, moral, keperawatan SPIRITUALITY RELATIONSHIP AND MORAL SENSITIVITY OF NURSING STUDENTS  ABSTRACTSpirituality as a belief is often associated with transcendent relationships that have an impact on individual attitudes and behavior, one of which is moral sensitivity in nursing. Moral sensitivity is an important provision in nursing practice and is a demand in providing health services holistically. The purpose of this study was to identify the relationship between spirituality and moral sensitivity of nursing students in Bali Province. This quantitative research with a descriptive correlational design included 122 nursing students in Bali as samples and used purposive sampling technique. Data was collected using demographic, spirituality and moral sensitivity data questionnaires. This study found that there was a relationship between spirituality and moral sensitivity of nursing students in Bali Province (r = 0.320, P <0.001). These results indicate that there is a weak relationship between both of variables with the direction of a positive relationship which means that the higher level of spirituality of nursing students then the higher level of moral sensitivity among nursing students. Other factors that can influence the moral sensitivity of nursing students need to be investigated further. Keywords: spirituality, sensitivity, morality, nursing
Hubungan bullying dengan ketidakberdayaan pada remaja
Authors: Utami Tantri Widyarti , Fadilah Alma , PH Livana
Published: February 2020

Bullying merupakan salah satu permasalahan yang terjadi pada remaja yang tidak hanya berampak terhadap harga diri saja tetapi juga terhadap pendidikan, kesejahteraan fisik dan mental.Tujuan penelitian adalah untuk mengetahui hubungan antara bullying dan ketidakberdayaan pada remaja Penelitian ini menggunakan desain penelitian cross sectional dengan metode simple random sampling yang melibatkan 231 siswa SMA. Instrument yang digunakan adalah instrument Revised Olweus Bully/Victim Questionairre (OBVQ), dan Learned Helplessness Scale. Sample menggunakan simple random sampling dengan kriteria inklusi remaja usia 15-17 tahun, berada  ditempat saat pengambilan data. Analisis data menggunakan uji chi square. Hasil penelitian menunjukkan adanya hubungan antara bullying dan ketidakberdayaan pada remaja remaja (p value = 0,000). Kata kunci: Bullying , ketidakberdayaan, remaja. THE RELATIONSHIP BETWEEN BULLYING ANDHELPLESSNESS IN ADOLESCENT ABSTRACTBullying is one of the problems that occur in adolescents that is  not only affect to self-esteem but also on education, physical and mental health  well-being. The aim of te study was to determine the relationship between bullying andhelplessness in adolescent. This study used a cross sectional study design with a simple random sampling method involving 231 high school students. the instrument used is Revised Olweus Bully/Victim Questionairre(OBVQ), and Learned Helplessness Scale. Sample technique used simple random sampling with the inclusion criteria of adolescents aged 15-17 years, and is there when taking data.Data analyis used the chi square test . Results shown there was an relationship  between bullying and helplessness in adolescent (p value = 0.0001). Keywords: bullying, helplessness, adolescent
Pengaruh terapi menulis ekspresif terhadap tingkat kecemasan remaja korban bullying
Authors: Niman Susanti , Saptiningsih Monika , Tania Clara
Published: February 2020

Tindakan bullying menimbulkan kecemasan dan harga diri rendah  pada korban. Remaja SMA korban bullying yang menjadi takut, dan malas pergi sekolah. Tujuan penelitian untuk diketahuinya pengaruh terapi menulis ekspresif  terhadap tingkat kecemasan. Kecemasan merupakan respons emosional ditandai dengan rasa takut, tegang dan gelisah. Menulis ekspresif adalah metode menulis untuk mengungkapkan  pengalaman emosional. Metode penelitian menggunakan kuantitatif dengan desain pre-experimental one group pretest-posttest. Instrumen menggunakan kuesioner Depression, Anxiety, Stress Scale (DASS-42) dengan mengambil subskala anxiety. Teknik sampel menggunakan total sampling sebanyak 20 korban bullying yang menderita kecemasan.  Analisa dilakukan dengan uji paired t-test. Hasil : p- value = 0,000 (< 0,05). Ada pengaruh terapi menulis ekspresif terhadap tingkat kecemasan.  Kata kunci: kecemasan, korban bullying, terapi menulis ekspresif EFFECT OF EXPRESSIVE WRITING THERAPYTOWARDS THE LEVEL OF ANXIETY ANALYSIS OF VICTIMS OF BULLYING ABSTRACTBullying causes anxiety and low self-esteem to the victim. Bullying teenagers who become scared, and are lazy to go to school. The purpose of this study was to determine the effect of expressive writing therapy on anxiety levels. Anxiety is an emotional response characterized by fear, tension and anxiety. Expressive writing is a method of writing to express emotional experiences. The research method uses quantitative with pre-experimental one group pretest-posttest design. The instrument uses the Depression, Anxiety, Stress Scale (DASS-42) questionnaire by taking the anxiety subscale. The sampling technique uses a total sampling of 20 bullying victims who suffer from anxiety. Analysis is done by paired t-test. Results: p-value = 0,000 (<0.05). There is an effect of expressive writing therapy on anxiety levels. Keywords: anxiety, victims of bullying, expressive writing therapy
Pengaruh pemberian terapi kelompok terapeutik anak usia toddler terhadap perkembangan psikososial anak usia toller
Authors: PH Livana , Susanti Yulia
Published: February 2020

Karakteristik anak usia toddler di kota Kendal bervariasi: ada yang sangat ceria saat  bermain dengan anak yang lain,  ada yang tampak mudah kesal, ada yang menangis ketika melihat  orang  baru,  dan ada anak  yang  cenderung  memilih  bermain  sendiri.  Perkembangan kepribadian saling berkaitan dengan hubungan sosial. Kombinasi perkembangan kepribadaian dan hubungan sosial disebut perkembangan psikososial. Perkembangan psikososial pada anak usia toddler dapat dicapai secara optimal melalui peran serta orangtua. Upaya yang dapat dilakukan perawat dalam mencegah keterlambatan perkembangan psikososial anak usia toddler yaitu dengan menstimulasinya melalui terapi kelompok terapeutik (TKT) untuk meningkatkan respons motorik, kognitif, emosional dan psikososialnya. Penelitian bertujuan untuk menganalisis pengaruh terapi kelompok terapeutik terhadap perkembangan psikososial anak usia toddler. Penelitian dilakukan di Bandengan, Kota Kendal. Desain penelitian quasi experiment dengan rancangan penelitian pre and post test without control group dengan menggunakan Purposive sampling berjumlah 42 anak.  Hasil  penelitian  dianalisis  menggunakan paired t test.   Hasil   penelitian  menunjukkan ada pengaruh pemberian terapi kelompok terapeutik anak usia toddler terhadap perkembangan psikososial anak usia toller denga nilai p = 0,000. Kata kunci: terapi kelompok terapeutik anak usia toddler, perkembangan psikososial anak usia toddler THE EFFECT OF PROVIDING THERAPEUTIC THERAPY FOR TODDLER-AGE CHILDREN ON THE PSYCHOSOCIAL DEVELOPMENT OF TOLL-AGE CHILDREN ABSTRACTThe characteristics of toddler-age children in Kendal city vary: some are very cheerful when playing with other children, some look irritable, some cry when they see a new person, and there are children who tend to choose to play alone. Personality development is related to social relations. The combination of personality development and social relations is called psychosocial development. Psychosocial development in toddler age can be achieved optimally through parental participation. Efforts that nurses can take to prevent delays in toddler psychosocial development are to stimulate them through therapeutic group therapy (TKT) to improve their motor, cognitive, emotional and psychosocial responses. The research aims to analyze the effect of therapeutic group therapy on the psychosocial development of toddler age children. The study was conducted in Bandengan, Kendal City. Quasi experiment research design with pre and post test without control group research design using purposive sampling totaling 42 children. The results of the study were analyzed using the paired t test. The results showed that there was an effect of therapeutic therapy for toddler age children on the psychosocial development of toll-age children with p = 0,000. Keywords: therapeutic group therapy for toddler, psychosocial development of toddler
Terapi Keperawatan terhadap Koping Keluarga Pasien Skizofrenia
Authors: Kitu Irene Febriany Mamo , Dwidiyanti Meidiana , Wijayanti Diyan Yuli
Published: February 2020

Permasalahan yang terjadi pada pasien skizofrenia tidak hanya melibatkan pasien itu sendiri tetapi juga melibatkan keluarga sebagai orang terdekat dari pasien tersebut. Keluarga mempunyai beban tersendiri saat merawat anggota keluarga yang mengalami gangguan jiwa. Terapi keperawatan diberikan kepala keluarga agar koping keluarga lebih efektif dalam menghadapi situasi yang ditimbulkan selama perawatan pasien skizofrenia. Literature ini bertujuan untuk mengetahui terapi keperawatan yang dapat digunakan pada keluarga agar koping keluarga lebih efektif. Metode yang digunakan dalam penulisan ini yaitu literature review dengan menggunakan artikel/ jurnal dari tahun 2003 – 2019 dan pencarian artikel melalui Science Direct, Google Scholar dan Pubmed. Tema artikel yang digunakan yaitu terapi keperawatan terkait dengan koping keluarga pasien skizofrenia. Hasil sintesa dari artikel-artikel yang telah ditelusuribahwa terapi keperawatan spesialis mampu mengatasi masalah koping pada keluarga pasien skizofrenia namun perlu adanya penelitian lebih lanjut tentang terapi keperawatan komplementer terhadap masalah koping keluarga pada pasien skizofrenia.  Kata kunci: terapi keperawatan, koping keluarga, skizofrenia  NURSING THERAPY TOWARD THE COPING OF FAMILLIES OF SCHIZOPHRENIC PATIENTS: A LITERATURE REVIEW ABSTRACTThe problems that occur in schizophrenic patients not only involve the patient himself but also involve the family as the closest person to the patient. Families have their own burdens when caring for family members who experience mental disorders. Nursing therapy is given by the head of the family so that family coping is more effective in dealing with situations caused during the treatment of schizophrenic patients. This literature aims to determine nursing therapy that can be used in families so that family coping is more effective. The method used in this writing is the literature review by using articles / journals from 2003 - 2019 and searching articles through Science Direct, Google Scholar and Pubmed. The theme of the article used was nursing therapy related to coping with the family of schizophrenic patients. The results of the synthesis of the articles that have been traced that specialist nursing therapy is able to overcome coping problems in the family of schizophrenic patients but need further research on complementary nursing therapy on family coping problems in schizophrenic patients  Keywords: nursing therapy, family coping, schizophrenic
Penerapan Assertiveness Training dan Terapi Kelompok Suportif Menggunakan Teori Stres Adaptasi Stuart dan Teori Adaptasi Roy
Authors: Winahayu Neng Esti , Hamid Achir Yani S. , Daulima Novy Helena Catharina
Published: February 2020

Perilaku kekerasan merupakan perilaku atau tindakan seseorang ketika tidak mampu mengatasi stressor yang dialaminya, ditunjukkan dengan perilaku aktual berupa kekerasan baik pada diri sendiri, orang lain, maupun lingkungan baik secara verbal maupun non verbal (Stuart, 2013). Tujuan penulisan karya ilmiah akhir ini adalah menggambarkan penerapan assertiveness training dan terapi kelompok suportif menggunakan Teori Stres Adaptasi Stuart dan Adaptasi Roy pada klien resiko perilaku kekerasan di Rumah Sakit Marzoeki Mahdi Bogor. Intervensi keperawatan yang dilakukan adalah assertiveness training pada 6 klien dan kombinasi terapi assertiveness  training dan terapi kelompok suportif pada 12 orang klien. Pelaksanaan assertiveness training dan terapi kelompok suportif dapat menurunkan tanda dan gejala perilaku kekerasan pada aspek kogitif, afektif, fisiologis, perilaku, dan sosial serta meningkatkan kemampuan adaptif dalam menghadapi peristiwa yang menimbulkan perilaku kekerasan. Kata kunci: risiko perilaku kekerasan, assertiveness training, terapi kelompok suportif, teori stres adaptasi stuart, adaptasi roy APPLICATION OF ASSERTIVENESS TRAINING AND SUPPORTIVE GROUP THERAPY USING THEORY OF STRESS ADAPTATION STUART AND THEORY OF ROY ADAPTATION APPROACH ABSTRACTViolent behavior occurs when a person is not capable of responding to stressors.  This behavior can be manifested by hurting oneself, others, or environment verbally or non verbally (Stuart, 2013). The purpose of this scientific paper was to report the application of assertiveness training and supportive group therapy utilizing the Stuart’s Stress-Adaptation Theory and Roy’s Adaptation Theory towards the clients with potential risk violent behavior who were hospitalized at  Marzoeki Mahdi Hospital in Bogor. Assertiveness training was conducted to six clients and combination of assertiveness training and supportive group therapy to twelve clients. The result of assertiveness training and supportive group therapy depicted that there were decreased signs and symptoms of violent behaviors at all aspects of cognitive, affective, physiological, behavior, and social as well as improvement of ability of clients to be more adaptive in responding to the any stressful situation that can stimuli violent behaviors.  It is recommended that assertiveness training and supportive group therapy can be used as a standard of mental health-psychiatric nursing specialized therapy.   Keywords: violent risk behavior, assertiveness training, supportive group therapy, stuart’s stress-adaptation theory and roy’s adaptation theory
Motivaciones para el emprendimiento social
Authors: García-Uceda Esperanza , Murillo-Luna Josefina L. , Asín Lafuente Jesús
Published: February 2020

El objetivo de este trabajo consiste en identificar y comprender las motivaciones que subyacen en la decisión de optar por el emprendimiento social como modelo de negocio. Para ello, la metodología utilizada consiste en un análisis exploratorio estructurado en tres etapas. Primero, se aplica la metodología Delphi para identificar las principales motivaciones, con la colaboración de 20 expertos en emprendimiento social. Después, se analiza la valoración tanto de estos expertos como de un grupo de 21 emprendedores sociales, sobre la importancia de las motivaciones identificadas en esta decisión. Finalmente, se realiza un análisis comparativo de las valoraciones de ambos grupos para detectar diferencias significativas entre sus percepciones. Entre los resultados obtenidos destaca el consenso en cuanto a la fuerza de motivaciones relacionadas con la autorrealización, por cumplir un sueño movido por una extraordinaria pasión. Por el contrario, existe discrepancia entre expertos y emprendedores sociales sobre la incidencia de las motivaciones ideológicas, fundamentadas en una profunda conciencia social, y de las motivaciones económicas y de empleo.
The Correlation Hypothesis revisited
Authors: Redzimska Joanna
Published: February 2020

The paper discusses motivation for metaphorical correspondences on the basis of the correlation of concepts, with special focus on conceptual blends. More specifically, it is centered around metaphorical meaning and possibilities that are offered by conceptual blends as tools for interpretation. A key part concerns the idea of the correlation hypothesis (Libura 2000) and its contribution to meaning creation. Providing an account of context-dependent (children’s animated films) meaning-construction, the research question assumes that the hypothesis of correlation serves as a useful tool for motivating, organizing and analyzing conceptual blends.
Intercultural and global dimension of textbooks – points of consideration for language teachers
Authors: Pogorzelska Marzanna , Biniecki Susan M. Yelich
Published: February 2020

As foreign language acquisition is potentially connected with shaping intercultural and global competences, this paper focuses on textbooks used for learning English to critically reflect on their diversity-related contents. The conceptual frame of the research is based on specific aspects of intercultural and global education, connections between them, and learning English and the hidden curriculum. The qualitative study of textbook analysis content allowed the authors to identify main themes related to ethnic diversity, including petrification with exotization, and povertization. Thus, the findings of the study highlight the limitations in fostering intercultural and global values in the analysed material and stress both the need for critical approach in classroom practice and further study in this area with the use of a theoretical framework suggested by the authors.
Evidence of cognitive effort in simultaneous interpreting: Process versus product data
Authors: Gumul Ewa
Published: February 2020

The present study aims at measuring the level of correspondence between the problems related to increased cognitive effort reported by simultaneous interpreting trainees in their retrospective verbal protocols and problems indicators identified in the target texts. The study triangulates process analysis (retrospective protocols) with product analysis (manual comparison of source and target texts). The corpus of the study consists of about 75 hours of recordings of 240 interpreting outputs and the recordings of 5,005 retrospective comments. The results imply that that increased cognitive load involved in simultaneous interpreting and the resulting cognitive effort experienced by trainee interpreters is not always manifested in the product.
Style of religious texts as a potential hindrance in interpreter training
Authors: Janikowski Przemysław
Published: February 2020

According to the thematic progression model of Janikowski (2011) religious texts can be used at the early stages of interpreter training. The reservations against such placement of allegedly stylistically sophisticated texts are scrutinised in the following paper by means of (1) developing a set of features of spoken religious discourse and (2) empirically testing their frequency in a convenience corpus. The results do show an unexpectedly high level of metaphorical saturation of spoken religious texts (1.4 per minute of speech), but they also show that only 8% of these metaphors were unconventional and that speakers sometimes employed special means of facilitating metaphor processing. Additionally, the appearance of other markers traditionally recognised as elements of religious style (intertextual allusions, markers of higher register and other figures of speech) was only marginal. Thus, the results support the use of religious texts as the second stage in thematic development, however, with a set of recommendations.
Large concomitant outbreaks of acute gastroenteritis emergency visits in adults and food-borne events suspected to be linked to raw shellfish, France, December 2019 to January 2020
Authors: Fouillet Anne , Fournet Nelly , Forgeot Cécile , Jones Gabrielle , Septfons Alexandra , Franconeri Léa , Ambert-Balay Katia , Schmidt Jeannot , Guérin Patrick , de Valk Henriette , Caserio-Schönemann Céline
Published: February 2020

On 27 December 2019, the French Public Health Agency identified a large increase in the number of acute gastroenteritis and vomiting visits, both in emergency departments and in emergency general practitioners’ associations providing house-calls. In parallel, on 26 and 27 December, an unusual number of food-borne events suspected to be linked to the consumption of raw shellfish were reported through the mandatory reporting surveillance system. This paper describes these concomitant outbreaks and the investigations’ results.
EŞKIYALARIN MERKEZİ DEVLET VE FEODAL OTORİTELERLE İLİŞKİLERİ
Authors: PIÇAK Murat , BULUT Mustafa , DEMİR Şeyhmus
Published: February 2020

Eşkıyalık, tarihin ilk devirlerinden başlayıp, uygar toplumların oluşumuna kadar geçen süre içerisinde, insanlığın devamlı olarak birlikte yaşamak zorunda kaldığı toplumsal bir olgudur. Eşkıyalık güçsüz devlet yapılarının ortaya çıkardığı bir olgudur. Merkezi devlet gücünün çeşitli sebeplerle zayıf düştüğü dönemlerde ekonomik ve sosyal yasalar geçersiz hale gelir; her çeşit haksızlık alıp yürür. Merkezi devlet otoritesinin çöküşü zulüm ve haksızlıkları artırır. Bu tür olumsuz koşullar toplumda bir hak arayışı, başkaldırı ve ayaklanma türü olan eşkıyalığı doğurur. Ayrıca yerel yönetim birimlerindeki olumsuzluklar da eşkıyalık faaliyetlerini körükler. Özellikle yöneticilerin yöre ahalisinden olduğu ve birtakım karmaşık yerel ilişkilerin içinde olduğu kesimler eşkıyalığa en elverişli bölgelerdir. Söz konusu bölgeler sosyo-ekonomik açıdan geri kalmış, merkezi otoriteden uzak ve ilgisiz kaldığı sürece, feodal güçlerin halkı yönlendirme kapasitesi yüksek, merkezi devlet politikalarının etki gücü düşük olur. Pre-kapitalist dönemi yaşayan ve toprak sahiplerince yönetilen bu bölgelerde, yörenin önde gelen yerli aileleri arasında daimi rekabet, eşkıyalara doğal bir talep yaratır ve onlara politik bir önem kazandırır. Bu yüzden yerel yönetimi elinde bulunduran feodal otoriteler, eşkıya ile uzlaşmak zorunda olmaktan ziyade; bundan çıkar sağlarlar.
Evaluation of Drought Tolerance Indices and Nitrogen Fertilization for Some Groundnut (Arachis Hypogaea L.) Genotypes
Authors: Paula Iancu , Ovidiu Păniță , Marin Soare
Published: February 2020

Water is essential to maximize crop yield and quality. This natural resource has assumed huge importance, especially in the warmest areas, where drought and environmental degradation has affected agricultural production. In order to identify drought tolerance of some groundnut genotypes and to investigate the relationships between seed yield, quality and drought tolerance indices a study was made using 10 promising genotypes. The experiment was carried out during 2014-2017 and sowed under randomized block design with four replicates. It included three factors: two levels of irrigation (a1 – non - irrigated and a2 - irrigated), two levels of fertilization (b1 – non-fertilized and b2 - 100 active Nitrogen/ha) and genotype (C1-C10). Seed yield depending on the influence of the factor, varied from 535.95 Kg/ha (non-irrigated) to 2020.95 Kg/ha (irrigated); from 1055.30 Kg/ha (non-fertilized) to 1501 Kg/ha (fertilized) and from 1111.30 Kg/ha to 1388 Kg/ha depending on genotype. Same influence factors for protein content varied from 25.65% (irrigated) to 28.61% (non-irrigated); from 26.33% (non-fertilized) to 27.93% (fertilized) and from 25.59% to 28.52% depending on genotype. Stress susceptibility index (SSI) varied from 0.964 to 1.040; Stress Tolerance Index (STI) from 0.138 to 0.435; Mean Productivity (MP) from 883.5 to 1616.0; Geometric Mean Productivity (GMP) from 750.3 to 1332.7; Tolerance index (TOL) from 933.0 to 1844.0; Harmonic Mean (HM) from 637.2 to 1099.0; Yield Index (YI) 0.777 to 1.308 and Yield Stability Index (YSI) from 0.236 to 0.309. High values of SSI, STI, YI, DI, RDI and SSPI indicate drought tolerance and those variants present high stability.
UPAYA MENINGKATKAN HASIL BELAJAR IPA MATERI DAUR AIR MELALUI MODEL PEMBELAJARAN PROBLEM BASED LEARNING
Authors: Setiowati Reni
Published: February 2020

The research was supported by the low learning outcome on science subject for fifth B grade SD Negeri 1 Bojongsari student. This is evidenced from the low cognitive evaluation based on the evaluation of data subjects of natural science that shows that there are still many students who have not attained mastery learning. The research was aimed at improving students’ natural science learning outcome on the material of the water cycle through Problem Based learning fifth-grade student of the elementary school. The subjects were the students of fifth grade SD Negeri 1 Bojongsari, there were 24 students, 10 male and 14 female ones. This classroom action research was conducted in two cycles. The data were collected from test and observation. An evaluation test was used to collect the data of the cognitive aspect of written tests conducted at the end of each cycle. Affective and psychomotoric evaluation worksheet was used to collect the data of affective and phsycomotoric aspect. The result showed the achievement mean in cycle I was 68,3 and then increased to 81,67 in cycle II. The result of the affective aspect the percentage in cycle I was 70,42% and increased to 85,62%. The result of phsycomotoric aspect the percentage in cycle I was 80,03% and increased to 90,1%. Finally, it can be drawn a conclusion that Problem Based Learning can improve students’ natural science learning outcome.
PENINGKATAN KEMAMPUAN PEMECAHAN MASALAH MATEMATIKA MELALUI MODEL PEMBELAJARAN PROBLEM BASED INSTRUCTION PADA POKOK BAHASAN BANGUN RUANG
Authors: Saputri Anggi
Published: February 2020

This research was aimed at improvingthe students’ mathematic problem solving competencethrough Problem-Based Instruction (PBI). The subject of this research was IV graders od SD Negeri 1Kalibagor consisting of 18 males and 19 females. The design of this research was Classroom ActionResearch which was carried out in 2 cycles in which every cycle consisted of 2 meetings. In each cyclethere were planning, acting, observing, and reflecting. The result of the research indicated that theimplementation of learning mathematic through Problem- Based Instruction learning model couldenhance the mathematic problem solving competence. This was proven by the increaseof the averagescore of mathematic problem solving competence. The average score inthe first cycle was 14.21 whichwas considered goog, and in the second cycle it was 16.69 which belonged to very good criteria. Theaverage result of students’ mathematic problem soving competencetest was 71.03 in the first cycle and83.51 in the second cycle. Furthermore, the students’ learning mastery was 51.40% in the first cycleand 89.19% in the second cycle whic indicated an improvement
PENERAPAN MODEL QUANTUM TEACHING UNTUK MENINGKATKAN KEMANDIRIAN DAN PRESTASI BELAJAR SISWA PADA MATA PELAJARAN MATEMATIKA MATERI KESEBANGUNAN DAN SIMETRI
Authors: Alfian Zaki Ruli Nur
Published: February 2020

Interviews and observations showed low learning achievement of independence and fifth-grade students of SD Negeri 2 Tinggarjaya, so this research aims to improve the independence and student achievement in the subjects of Mathematics material congruency and symmetry. This research is the subject of a class action that takes fifth-grade students with a number of 30 students consisting of 12 men and 18 women. This study uses a model of Quantum Teaching is carried out2cycles, each cycle consisting of 2 meetings. Each cycle consists of planning, implementation, observation/observation, and reflection. Based on the result obtained in the first cycle, students' independence as much as79,58% with both criteria and the second cycles much as89,18%, thus increasing the criterion very well, while the acquisition of student achievement obtained in the first cycle the average value of the class of 58,67 with passing grade is achieved only 60%. in the second cycle, the acquisition of student achievement obtained an average value of 89,25class with mastery learning reaches 88,9%. The collection of data through questionnaires and student evaluation sheet, Quantum Teaching shows that the model can improve the independence and student achievement in the subjects of Mathematics material congruency and symmetry.
PENINGKATAN SIKAP PEDULI SOSIAL DAN PRESTASI BELAJAR MATA PELAJARAN PENDIDIKAN KEWARGANEGARAAN MELALUI MODEL KOOPERATIF TIPE STAD
Authors: Sitirah Sitirah
Published: February 2020

The background of this research is the lack of social care attitude and student’s achievement. This research is aimed to increase the social care attitude and student’s achievement in PKn (Civic) subject in the material of globalization effect through cooperative learning model of ( Student Teams Achievement Division)STAD type. The subject of research is the students of 4th grader of SD 02 Kedungwuluh Kidul with the total number of student are 16. Class action research was held in two cycles. Each of cycle consists of two meetings, one meeting consists of two hours. The procedure for each cycle included planning, action, observation, and reflection. The data collection was gotten from teacher’s observation and students’ activity report. To know the students’ social attitude, the researcher used social care attitude questionnaire. While to get the data of students’ achievement, the researcher used the evaluation sheet at the end of each cycle. Based on the research of social care attitude in cycle I, it was shown that the average was 3,20 and the percentage was 80,15% and from Cycle II, the average was 3,67 and the percentage was 91,87%. The result of achievement scoring from cycle I, the class average was 72,81 with the percentage81,25% and from the cycle, II was got the class average was 86,87 with percentage 100%. From those results, can be concluded that cooperative learning method (Student Teams Achievement Division)STAD type can enhance the social attitude care and students achievement of PKn of class IV SD 02 Kedungwuluh Kidul.
Perancangan Aplikasi M-Learning Seni Budaya dan Keterampilan Kelas 5 Berbasis Android di MI Sirojul Athfal
Authors: Apriani Nur , Paramita Aulia , Handayani Shinta Dwi
Published: February 2020

Mata pelajaran Seni Budaya dan Keterampilan sering juga disebut SBK dianggap mata pelajaran yang kurang diminati oleh murid kelas 5 di MI Sirojul Athfal karena siswa lebih memperhatikan mata pelajaran produktif seperti matematika. Selain Kurang diminati oleh siswa ternyata media ajar yang digunakan oleh guru dalam pembelajaran kurang efektif, karena guru masih mengandalkan buku teks dalam penyampaian materi. Sehingga, murid-murid kurang bisa memvisualisasikan pelajaran SBK dengan baik. Tujuan penelitian adalah untuk memberikan solusi kepada tempat penelitian terkait menerapkan media digital dalam proses pembelajaran SBK dengan membuat suatu aplikasi dan mempermudah dalam membuat penilaian terhadap murid-murid yang telah berhasil mengerjakan evaluasi. Metode penelitian yang digunakan dalam perancangan aplikasi M-Learning yaitu metode SDLC (System Development Life Cycle) yaitu pendekatan yang bertahap untuk melakukan analisa dan membangun suatu rancangan sistem dengan menggunakan siklus yang lebih spesifik terhadap kegiatan pengguna. Sehingga peneliti dapat menarik kesimpulan bahwa pihak sekolah dan murid kelas 5 diberi kemudahan dalam melaksanakan proses pembelajaran dengan mengimplementasikan media digital atau aplikasi yang telah dirancang dan dibangun dengan tersistem dan terstruktur, sehingga tingkat kerusakan dalam proses pembelajaran menggunakan media cetak dapat teratasi. Sekolah juga dapat dipermudah dalam membuat penilaian dari hasil evaluasi kepada murid-murid yang telah mengerjakan evaluasi melalui aplikasi.
A new species of Corydalis (Fumariaceae) from Gansu (China)
Authors: Mikhailova M. A.
Published: February 2020

A new species Corydalis qilianshanica Mikhailova (sect. Strictae (Fedde) Wendelbo) is described from Northwest China, Gansu Province, Nanshan mountain system, Qilian Shan (Richthofen Range). The species differs from C. stricta Stephan ex DC. by growth form with numerous persistent last year’s old stems, usually branched racemes, bipinnate leaves with flabellate segments, and larger basal leaves, as well as by rocky habitat.
Species of Hedysarum ucrainicum affinity (section Multicaulia, Fabaceae)
Authors: Knyazev M. S.
Published: February 2020

The review of the species related to Hedysarum ucrainicum Kaschm. (sect. Multicaulia; Fabaceae) is given. The species of the H. ucrainicum affinity are well distinct from all races of polymorphic H. gmelinii Ledeb. by persistent and hanging in fruit (not directed upwards) flowers; differ from all species of the H. severzovii Bunge affinity (H. pavlovii Bajtenov, H. dmitrievae Bajtenov, H. nikolai Kovalevsk. and others) by narrower beans (3–4 mm, vs. 6–7 mm wide). New species H. ulutavicum Knjaz. and H. tarbagataicum Knjaz. are described; the rank of H. schellianum var. villosum Knjaz. is increased up to the species, with a replacement name H. villosissimum Knjaz. The distribution map of the studied species is given.