bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluating the Structure of the Aesthetic Responsiveness Assessment (AReA) with Bootstrap Exploratory Graph Analysis
Authors: Silvia Paul , Rodriguez-Boerwinkle Rebekah , Awa Kim N. , Zabelina Darya , Christensen Alexander P.
Published: December 2023

The Aesthetic Responsiveness Assessment (AReA) is a brief self-report scale for measuring individual differences in the strength of responses to art objects and events. Its 14 items sort into three subscales measuring aesthetic appreciation (AA), intense aesthetic experience (IAE), and creative behavior (CB). Given the scale’s growing popularity, the present research evaluated the dimensionality of the AReA using tools from network psychometrics, particularly bootstrap exploratory graph analysis. Using a large sample of English-speaking adults (n = 1071), the analyses examined the stability of the number of dimensions and their items. Overall, the number and item composition of the AReA subscales was closely replicated, but one of the scale’s items—a cross-loaded item proposed to appear in both the AA and IAE subscales—was not replicated. Using the bootstrap sampling distributions, we suggest item assignments for the three subscales that avoid awkward dual-loadings and provide a simpler dimensional structure. Taken together, the results reveal some clear strengths of the AReA and illustrate how emerging network tools can illuminate and guide psychometric decisions.
Emotional modulation of visceral pain is associated with fear of pain and serotonergic polymorphisms
Authors: Weltens Nathalie , Brunner-Schaub Nora , Farmer Adam , Aziz Qasim , Wahl Verena , Niesler Beate , Tack Jan , Van Oudenhove Lukas , Coen Steven J
Published: December 2023

Objective Emotions are assumed to influence visceral pain perception, but experimental evidence supporting this is limited and especially the underlying mechanisms are poorly understood. We investigated emotional modulation of subjective and parasympathetic responses to visceral pain as well as potential psychobiological sources of inter-individual variability. Methods Ninety-six healthy subjects participated in a mechanistic study during which negative, positive and neutral emotions were induced in 3 experimental runs, in counterbalanced order. Esophageal balloon distensions at pain tolerance were pseudo-randomly applied in each run to evoke visceral pain. Subjective emotional state was assessed at set time points, perceptual pain responses after each distension, and cardiac vagal tone (CVT) continuously. Affective traits were assessed using questionnaires, and participants were genotyped for selected serotonergic gene polymorphisms. Results Subjective pain ratings were higher and lower during negative and positive emotion, respectively, versus neutral (all p<0.0001), and habituated upon repeated stimulation during positive (p<0.0007) and neutral (p<0.0058), but not negative (p>0.66), emotion. Fear of pain scores and polymorphisms in the serotonin receptor type 3B and serotonin transporter were associated with inter-individual differences in such emotional pain modulation (all p<0.05). Finally, CVT responses to pain were higher during negative (p=0.059) and lower during positive emotion (p=0.031), respectively, versus neutral. Conclusions We show that positive and negative emotions modulate subjective and parasympathetic responses to esophageal pain, and identify fear of pain and serotonergic gene polymorphisms as drivers of inter-individual variability in such pain modulation. These findings may help to identify subjects at risk for developing chronic visceral pain.
Cash-Based Interventions Improve Multidimensional Integration Outcomes of Venezuelan Immigrants
Authors: Ahrens Achim , Hangartner Dominik , Casalis Marine , Sanchez Rodrigo
Published: December 2023

Since 2015, over 7 million Venezuelans have been forced to leave their homes, seeking refuge predominantly in neighboring countries across Latin America and the Caribbean. The displacement is typically accompanied by vulnerability and marginalization, yet there is a scarcity of actionable evidence on how to alleviate poverty among immigrants and refugees and facilitate their economic, political, and social integration. This study evaluates the impact of a cash-based intervention (CBI) on multidimensional integration outcomes of highly vulnerable Venezuelan immigrants in Peru. Utilizing an original panel survey of beneficiaries and the staggered rollout of the program, which provided a one-time payment of 760 soles (approximately 190 USD or 74% of the monthly minimum wage), we estimate that the CBI increased the IPL-24 index---an overall measure of immigrant integration capturing several dimensions---by at least 0.12 standard deviations. This increase is mainly driven by improvements in the navigational, social and economic components of the IPL-24 index. Moreover, the CBI boosted self-employment by 2 percentage points and raised the intention to emigrate from Peru by 1.2 percentage points. Additionally, our heterogeneity analysis reveals that the benefits of the fixed-amount cash payment diminish significantly with the size of the household. We discuss how these findings inform the design of future CBI programs aimed at supporting vulnerable immigrant and refugee families.
Educating people about Quantum Technologies: Teaching Techniques and Potential Problems
Authors: Shivansh
Published: December 2023

Quantum technologies are growing at a rapid pace with thousands of big impact researches every year and isa prominent candidate in the race of future technology. Despite all the efforts and progress made in this field,general public does not contain enough knowledge to harness any benefit from this prosperous field of quantumtechnologies and computation. The biggest complication in attaining knowledge in this field is that it is difficultfor students and even professional to attain this knowledge as the subject has an increased complexity level andthe sources of knowledge are limited. The paper tries to resolve this problem by classifying people into categoriesaccording to their special needs and uses of quantum technologies and tries to put the forward ways that could beadopted in the educational environment to distribute knowledge to each category so they are in a good conditionto harness the potential of the field. The paper also discusses about the potential problems in implementingthese strategies to educate people about quantum technologies.
Criminal governance in a large European city: the case of gangs in London
Authors: Campana Paolo , Varese Federico , Meneghini Cecilia
Published: December 2023

This study explores criminal governance by introducing a novel survey instrument, the Crim-Gov questionnaire, and applying it to gangs operating in London. We show that only a subset of gangs is involved in criminal governance, impacting 4.7% of all communities. Our models show that while socioeconomic disadvantage increases all types of gang presence, barriers to local services, including affordable housing, only increase the probability of governance-type gangs. Criminal governance is more likely to emerge when services provided by local and central authorities are of lesser quality. Communities with governance-type gangs also exhibit lower trust in social and state institutions and a certain degree of residential stability. The study highlights the need for diverse interventions based on gang type.
The incongruity of misfit: A systematic literature review and research agenda
Authors: Englert Benedikt , Sievert Martin , Helmig Bernd , Jansen Karen
Published: December 2023

For decades, research on person–environment (P-E) fit has been a prevalent topic, emphasizing alignment between employees and the work environment and the accompanying positive consequences that flow from good fit. However, given the frequency of change and volatility experienced in organizations, it is far more likely that individuals, work groups, and organizations will sporadically experience misfit with various aspects of the environment. This recognition has led to steady growth in misfit research, but this literature lacks conceptual clarity, provides differing views on the interplay between fit and misfit, and as a result, insights on the consequences of misfit are fragmented. To address these shortcomings, we conducted a systematic review of the misfit literature and analyzed 106 scholarly articles published between 1981 and 2021. Our review offers three key contributions. First, we identify four distinct conceptualizations of misfit from the literature and then offer an integrative definition of misfit. Second, we provide a multi-level synthesis of the antecedents and outcomes of misfit that highlights the need for more cross-level and multi-level research. Third, we lay out a rich and detailed agenda of future research to further enhance our knowledge of misfit as a concept distinct from its P-E fit roots.
General Skill Acquisition during Non-Academic Pathways from School to Work: Investigating Social Inequalities among Low- and Medium-Educated Young Adult
Authors: Kroh Jacqueline , Nester Markus , Wolter Ilka
Published: December 2023

There is a burgeoning literature examining how individuals acquire their skills in different educational settings. However, limited research has focused on the development of general skills during the school-to-work transition (STWT) period in the context of vocational education and training. Consequently, this area remains under-researched, leading to an incomplete understanding of skill acquisition during this phase of education. This investigation addresses this gap by examining how the general skills of low- and medium-educated individuals in Germany develop during the STWT period. Using data on young adults from the German National Educational Panel Study, this research investigates the development of literacy and numeracy skills from grade 9 onward in different STWT patterns, reflecting differences in continuous and consecutive duration of vocational education programs. In general, findings suggest that both types of skills develop over time and growth rates decline over time. Individuals with fragmented participation in VET and prevocational measures, such as those characterized by repeated participation in pre-vocational programs, periods of unemployment, and gaps, appear to have the lowest rates of skill growth. Consequently, we conclude that the STWT period appears to exacerbate social inequalities in general skill levels in addition to general education.
Identifying patterns and recommendations of and for sustainable open data initiatives: a benchmarking-driven analysis of open government data initiatives among European countries
Authors: Lnenicka Martin , Nikiforova Anastasija , Luterek Mariusz , Milic Petar , Rudmark Daniel , Neumaier Sebastian , Santoro Caterina , Flores Cesar Casiano , Janssen Marijn , Rodríguez Bolívar Manuel Pedro
Published: December 2023

Open government and open (government) data are seen as tools to create new opportunities, eliminate or at least reduce information inequalities and improve public services. More than a decade of these efforts has provided much experience, practices, and perspectives to learn how to better deal with them. This paper focuses on benchmarking of open data initiatives over the years and attempts to identify patterns observed among European countries that could lead to disparities in the development, growth, and sustainability of open data ecosystems. To do this, we studied benchmarks and indices published over the last years (57 editions of 8 artifacts) and conducted a comparative case study of eight European countries, identifying patterns among them considering different potentially relevant contexts such as e-government, open government data, open data indices and rankings, and others relevant for the country under consideration. Using a Delphi method, we reached a consensus within a panel of experts and validated a final list of 94 patterns, including their frequency of occurrence among studied countries and their effects on the respective countries. Finally, we took a closer look at the developments in identified contexts over the years and defined 21 recommendations for more resilient and sustainable open government data initiatives and ecosystems and future steps in this area.
And Never the Twain Shall Meet? Institutional Open Access Policies (IOAPs) and Review, Promotion, and Tenure (RPT)
Authors: Makula Amanda
Published: December 2023

Introduction: Institutional open access policies (IOAPs) express an institutional commitment to making scholarly knowledge openly accessible, typically by asking academics to deposit their scholarship into an open access (OA) repository. Faculty, however, must prioritize other scholarly requirements, such as those specified in review, promotion, and tenure (RPT) processes and policies. If IOAPs are ignored or in conflict with RPT, they will not be as effective as possible. Literature Review: Despite the fact that many higher education institutions say they value scholarly research contributing to the public good, they often do not articulate that OA is a necessary component to achieve this goal. Parallelly, increasing numbers of higher education institutions have adopted an IOAP, but few of them include the policy in RPT policies. Methods: An electronic survey was disseminated to members of the Coalition of Open Access Policy Institutions (COAPI) in order to quantify how many include the concept of OA and/or their IOAP in their RPT mechanisms. Results: Only four out of 28 respondents indicated that the concept of OA is integrated into RPT at their institution, and only one out of 28 reported that the IOAP is present in RPT. Discussion: Consistent with sparse examples in the literature, this study suggests that most IOAPs exist in separation from RPT, and this separation threatens the success of IOAPs. Conclusion: Faculty prioritize RPT guidelines in order to advance their careers, but these policies rarely address OA and IOAPs. More attention to the relationship between IOAPs and RPT is necessary in order to discover how they can complement one another and enhance scholarly knowledge production and exchange.
Prospects of aquaculture of West Bengal, India under Changing climate
Authors: Banerjee Abira
Published: December 2023

Climate variability refers to the variability observed in the climate record in periods when the state of the climate system is not showing changes. If the climate state changes, usually characterized by a shift in means, then the frequency of formerly rare events on the side to which the mean has shifted might occur more frequently with increasing climate variability. Natural variability is a characteristic of the global climate and occurs on both long and short-time scales. Aquaculture practices involve the breeding, rearing, and harvesting of aquatic organisms in freshwater, brackish water, or marine environments. Aquaculture is a rapidly growing sector of nutrition security in Gangetic West Bengal. A study was conducted on West Bengal in India, one of the eastern states of India. West Bengal state has different types of agroclimatic zones. Aquaculture in West Bengal has tremendous potential to grow as an industry. Residents of West Bengal must understand the value of local wetlands and the importance of the conservation of wet lands. Government institutes should collectively work with different educational hubs, scientists, and NGOs on beneficial issues of the state so that aquaculture conservation and development and appropriate adaptation strategies can be adopted.
MANAJEMEN METADATA ARSIP AUDIO DENGAN APLIKASI SEDERHANA PERKANTORAN PADA MUSEUM MUSIK INDONESIA
Authors: Anastasya Diva , Mihasu Narocha , Cornellya Safira , Nikmah Farika
Published: December 2023

Metadata provides the necessary context to understand and organize systems, data, and content management. Thus the metadata in the archive has a fairly important role, with the existence of archive metadata it will facilitate the management of archives, both static archives or dynamic archives. At the Indonesian Music Museum in Malang City, there are various collections of audio archives from all over Indonesia which are static archives that need to be preserved for their authenticity and physicality as they are part of Indonesia's cultural heritage. The archive collection is divided into various forms, namely in the form of tape cassettes, CDs, and LPs. This study aims to describe the needs of metadata management within the scope of electronic records management. Metadata management is compiled by recording a collection of audio archives on tape cassettes for the pop song category at the Indonesian Music Museum. The metadata management development approach uses a simple office application with Microsoft Access media, so that the audio archive metadata in the Indonesian Music Museum can be digitally compiled. Of course, this can facilitate audio archive retrieval activities and their maintenance.
PEMBERDAYAAN MASYARAKAT PEMANFAATAN LIMBAH KELAPA SAWIT SEBAGAI NILAI TAMBAH UNTUK PENGHASILAN MASYARAKAT DI DESA BLANG MANE KECAMATAN PEUSANGAN SELATAN KABUPATEN BIREUEN
Authors: Elfiana Elfiana , Nursayuti Nursayuti , Desparita Naya
Published: December 2023

Sebagai upaya dalam menerapkan pertanian yang berkelanjutan, produksi limbah yang dihasilkan oleh komoditas kelapa sawit sangat meresahkan masyarakat, hal ini memberikan dampak yang besar terhadap lingkungan dan pengelolaan lahan perkebunan yang belum efisien. Limbah yang dihasilkan oleh tanaman kelapa sawit terdiri dari pelepah, daun dan bungkil buah, limbah ini mampu memebrikan efek kurang baik bagi lingkungan jika tidak diolah menjadi produk bernilai guna. Dampak yang sering terjadi yaitu polusi yang disebabkan oleh pembakaran limbah kelapa sawit yang sering dkhawatirkan oleh warga setempat dikarenakan asap yang dihasilkan menggangu aktivitas masyarakat. Selain itu jika dibiarkan tanpa adanya pengolahan lanjut akan berdampak pada penecemaran air sumur dan sungai. Namun demikian belum ada dari pihak pemerintah maupun instansi terkait yang memberikan pengarahan kepada petani sawit ataupun kelompok tani tentang pemanfaatan limbah kelapa sawit yang dapat diolah menjadi berbagai jenis produk salah satunya menjadi pakan ternak. Hal ini mendorong kami pihak instansi perguruan tinggi untuk melakukan pengabdian agar permasalahan limbah dari kelapa sawit ini dapat teratasi. Dengan pengakserelasi pembangunan kelapa sawit secara berkelanjutan maka permasalahan tentang limbah yang dihasilkan dapat diatasi dan memberikan nilai tambah kepada pihak kelompok tani makmur. Selama ini permasalahan yang dihadapi dilapangan adalah kurangnya pengetahuan dari pihak masyarakat terkhususnya kelompok tani makmur tentang manfaat dari pelepah dan daun kelapa sawit yang dapat diolah sebagai pakan ternak. Tujuannya adalah mengubah sudut pandang kelompok tani makmur dalam memanfaatkan limbah kelapa sawit, memberikan ketrampilan baru bagi kelompok tani makmur sehingga ketrampilan tersebut dapat diaplikasikan dalam kegiatan yang produktif selain itu juga mampu menambah nilai tambah limbah menjadi pakan ternak. Luaran yang ditargetkan yaitu pihak sasaran memperoleh pengetahuan, ketrampilan dalam mengatasi permasalahan limbah kelapa sawit dan terbentuk suatu produk yang mampu meningkatkan nilai tambah sasaran kelompok tani makmur sehingga nantinya akan mandiri dan diharapkan dapat menambah penghasilan pihak kelompok secara mandiri.
PEMBUATAN ECO ENZYME DAN POC DENGAN MEMANFAATKAN SAMPAH RUMAH TANGGA ORGANIK MENUJU ZERO WASTE
Authors: Arbiwati Dyah , AZ Abdul Rizal , Sandhi Indah Kartika , Al Rosyid Ali Hasyim
Published: December 2023

According to data from the Kementerian Lingkungan Hidup dan Kehutanan (2022), waste production in Indonesia is around 36 million tons per year and unmanaged waste is around 13.5 tons per year (37.45%). Waste production in Daerah Istimewa Yogyakarta is around 800 thousand tons per year, and  50.17% of it is household waste. The total volume of waste brought to the Piyungan landfill is around 700 tons/day, around 55 percent of it is organic waste. Each person produces around 0.68 kg of waste per day, so waste management must be the responsibility of all people communities as waste producers. The aim of community service activity is to increase knowledge, skills and motivate also raise awareness of KWT Cabe Rawit members in Jambon Village as partners in processing household waste into eco enzyme and Liquid Organic Fertilizer using the stacked bucket technique, so that it can support the zero waste movement. The implementation methods in community service activities including lectures, training and practice. The outputs that will be produced are publications in national seminar proceedings with ISBN, publications in electronic mass media, books with ISBN, videos, posters and increasing partner empowerment. All members of the KWT Cabe Rawit members in Jambon Village understand and are skilled in making eco enzymes and Liquid Organic Fertilizer from organic household waste and their benefits. The quality of Liquid Organic Fertilizer using the stacked bucket technique is an organic C content of 2.76%, 0.14% total N, C/ N 19.71, P2O5 0.0041 %, K2O 0.023% and pH 5.7. The quality of compost using the stacked bucket technique is organic C content 42.26%, total N 3.67%, C/N 11.51, P2O5 0.39%, K2O 0.17% and pH 6.2 and pH eco enzyme 3 .5Keywords: Eco enzyme, Household waste, Liquid organic fertilizer, Zero waste
PELATIHAN PENGEMASAN PUPUK ORGANIK PADAT DAN CAIR DI KELOMPOK TANI MEKAR SARI DUSUN KELOR BANGUNKERTO TURI SLEMAN
Authors: Wahyurini Endah , Suryawati Ami , Gumelar Rima Margareta Retnyo , Huda Amalia Nurul , Nabila Nailan
Published: December 2023

Kelor Bangunkerto Turi Sleman Hamlet has become a tourist spot, the people there are a group of farmers whose highlands are planted with snake fruit and horticultural crops. Plant waste in the form of dry leaves and household waste is processed into compost and liquid organic fertilizer, in an effort to reduce the use of chemicals on plants. The main problem faced by farmers is that the quality of organic fertilizer packaging is not yet optimal, which is attractive and can last a long time. The aim of this community service is to provide training and mentoring in technical skills for packaging solid and liquid organic fertilizers that are attractive and safe so that they are suitable for sale. The method used was socialization followed by training on packaging solid and liquid organic fertilizer, training on packaging design and procurement of packaging equipment. The results of this service are increased knowledge, skills and welfare of the community, solid organic fertilizer products in plastic packaging, liquid organic fertilizer products in plastic jerry can bottles, branding logo for fertilizer produced by KT MEKAR SARI Kelor, Bangunkerto Turi Sleman DIY.
Cilnidipine Nanocrystals, Formulation and evaluation for Optimization of solubility and Dissolution Rate
Authors: A. Al Hazzaa Suray , Rajab Nawal A.
Published: December 2023

Cilnidipine CLD fourth generation Ca+2 channel blockers, since cilnidipine has a very low solubility (BCS Class-II drug Low solubility High permeability) and extremely low medication compliance, it has been used to treat hypertension and hypertensive-associated vascular disorders.so cilnidipine can be formulated as nanocrystals NCs  using solvent anti-solvent technology which can improve the solubility and bioavailability .Two different stabilizers(poloxamer 188 and Tween20) were utilized to prepare  nine formula  with different ratio 1:0.25,1:0.5 and 1:1. Study and evaluation the formulation factors which may effect on particle size and Polydispersity index PDI. The prepared CLD NCs were evaluated for particle size and dissolution study ,F4 was the smallest size 152 nm ,PDI  (0.161 )and the saturated solubility was increased about ten folds, this formula was subjected for freeze drying by adding  3 % mannitol as cryoprotectant .A complete dissolusion was established in about 20 minutes  which confer the DSC and PXRD results in conversion from crystalline into amorphous state .It can conclude that solvent  anti-solvent technique was a useful in preparation of nanocrystals suspension .
Diacerein Loaded Novasome for Transdermal Delivery: Prepartion , In-Vitro Characterization and Factors Affecting Formulation
Authors: Albassam Noor Yousif , Kassab Hanan Jalal
Published: December 2023

Diacerein (DCN) is a semi-synthetic anthraquinone derivative of Rhein that is indicated for the management of osteoarthritis. Diacerein exhibits poor dissolution in the GIT fluids and suffers from low bioavailability upon oral administration in addition to the laxative effect of Rhein metabolites. The aim of the present study was to develop novasomal vesicles with optimized entrapment efficiency and size to serve as a carrier for transdermal delivery of diacerein. Novasomal vesicles were prepared by thin film hydration method thin film hydration. The prepared vesicles were optimized utilizing different surfactant to cholesterol molar ration, sonication type, different sonication times and varying fatty acid level. The prepared vesicles were characterized for drug entrapment efficiency, vesicle size and PDI. The best formula was further investigated for zeta potential ten TEM and compatibility study by FTIR analysis. Results showed that F6 was the best formula regarding it vesicle size 275.2± 2.68nm , entrapment efficiency 69.415± 0.234 % and PDI 0.309± 0.016. In conclusion , novasomal dispersion could be successfully formulated with thin film hydration method.
Keywords: Diacerein , Novasome , Transdermal Delivery  ,Vesicular System .
Solubility and Dissolution Enhancement of Atorvastatin Calcium using Phospholipid Solid Dispersion Technique
Authors: Bashar K. K. Ghyadh  , Al-Khedairy Eman
Published: December 2023

Atorvastatin (ATR) is a poorly water-soluble anti-hyperlipidemic drug. The drug belongs to the class II group according to the biopharmaceutical classification system (BCS) with low bioavailability due to its low solubility. Solid dispersion is an effective technique for enhancing the solubility and dissolution of drugs. Phospholipid solid dispersion (PSD) using phosphatidylcholine (PC) as a carrier with or without adsorbent (magnesium aluminum silicate, silicon dioxide 15nm, silicon dioxide 30nm, calcium silicate) was used to prepare ATR PSD using different drug: PC: adsorbent ratios by solvent evaporation method. The resulted PSD was evaluated for its percentage yield, drug content, solubility, dissolution rate, Fourier transformation infrared spectroscopy (FTIR), powder X-ray diffraction study (PXRD), and differential scanning calorimetry (DSC). The prepared (PSD) showed improvement in drug solubility in all prepared formulas. The best result was obtained with F5 (ATR: PC: MAS 1:3:4). The solubility was increased by 21 folds compared to the pure drug with enhanced dissolution and decrease crystallinity.
Synthesis, Characterization, Anti-Inflammatory, and Antimicrobial Evaluation of New 2-Pyrazolines Derivatives Derived from Guaiacol
Authors: Mervat Mohammed K  , Tagreed N-A Omar
Published: December 2023

Abstract:

        Chalcones were used to synthesis series of 2-pyrazoline derivatives and evaluated their antimicrobial and anti-inflammatory activities

       (E)-1,3-diphenylprop-2-en-1-one (1-5) were synthesized by Claisen-Schmidt Condensation method through the reaction of acetophenone with five various para substituted benzaldehyde in presence of KOH, the reaction monitoring by TLC and the result intermediates were checked by melting point and FT-IR

Various 2-Pyrazoline derivatives were prepared by one pot reaction that involved the refluxing of (E)-1,3-diphenylprop-2-en-1-one (1–5) and Hydrazine monohydrate in the presence of glacial acetic acid for 24 hours at a temperature of (45–50) °C for a duration 24 hrs. pyrazoline II (1-5) was formed, then antioxidant compound (guaiacol) was added reflex for 24-48 hours, monitoring by TLC to ensure the reaction was completed. The final mixture was cooled in ice-water bathe until the formation of crystals were completed, added to crushed ice, kept in refrigerator overnight, filter, recrystallized and then dried to get 2-pyrazoline derivatives, IIIa, IIIb, IIIc, IIId and, IIIe. based on the spectral data 2-pyrazoline derivatives structures have been confirmed. The synthesized compounds were screened for their antimicrobial activity and anti-inflammatory.
Synthesis and Preliminary Anti-Inflammatory and Anti-Microbial Evaluation of New 4,5-Dihydro-1H-Pyrazole Derivatives
Authors: Shaymaa Kanaan K.  , N-A Omar Tagreed
Published: December 2023

Abstract

     Organic compounds with pyrazole cores have a variety of uses, notably in the pharmaceutical and agrochemical sectors. The interest in creating pyrazole compounds, examining their many features, and looking for potential uses is growing. Our work has concert with synthesis of  chalcones and pyrazolines, then finally pyrazoline-aniline derivatives and evaluation their anti-inflammatory, antibacterial and antifungal activities
Factors associated with Adherence to Insulin Self-Administration among Children and Adolescents with Type 1 DM in Iraq
Authors: Jabbar Ruqayah Kareem , Mohammed Yawz Jammal
Published: December 2023

Abstract
Adolescents and children with type 1 diabetes have been reported to have challenges regarding adherence to treatment regimens compared with other age groups with diabetes. The study aimed to determine the level of commitment and investigate the effects of different factors on insulin adherence in type 1 diabetes patients in Iraq. This cross-sectional study included face-to-face interview questionnaires with caregivers of children and adolescents. Interviews were conducted in the Specialized Center of Endocrinology and Diabetes in Nasiriyah City, Iraq, from October 4, 2022, to March 30, 2023. The adherence questionnaire consisted of two sections; each consisted of five questions, including insulin and blood glucose recommendations. Blood samples were obtained from the patient to determine fasting blood glucose (FBG) and glycated hemoglobin (HBA1c)—results: 180 patients (86 males and 94 females) with type 1 DM. The mean age, weight, and disease duration were 10.75 (4.36) years, 36.30 (16.41) kg, and 6.24 (3.70) years, respectively. They had uncontrolled blood glucose (208.42 95.0 mg/dl) and HBA1c (9.90 2.85%). The patients (52.2%) were girls with primary school qualifications (43.3%). Most of the caregivers (parents and guardians) were either illiterate (30.6%) or had completed primary school (33.9%). In addition, the patient's families (43.9%) had low income (0.5 million ID cards). Therefore, most patients (60%) did not visit a doctor regularly or check their blood glucose. Adherence in the studied population could be higher. Focusing on raising their patients' awareness is pivotal to enhancing their medication adherence to reduce their short- and long-term diabetic complications, improve blood glucose control, and improve clinical outcomes.
Keywords: Diabetes, Adherence, Insulin self-medication, Iraqi patients.
Preparation and characterization of vemurafenib microemulsion
Authors: Neamah Mohammed Jassim , Entidhar J. Al-Akkam
Published: December 2023

Human melanoma is the most common and malignant type of skin cancer. Vemurafenib has been used for the treatment of malignant or metastatic melanoma. Oral vemurafenib has serious adverse drug reactions including
QTc sigment prolongation of heart ECG that may result in discontinuation of treatment. The aim of study was to prepare o/w vemurafenib microemulsion to be used for topical administration. Saturated solubility of vemurafenib were performed in different oils, surfactants and co-surfactants. Peppermint oil, Tween 20 and PEG 400 were chosen to be the oil phase, surfactant and co-surfactant repectively. Since, vemurafenib had the highest solubility in these materials. Six fromulas (F1- F6) of vemurafenib microemulsion were prepared by simple titration method and characterized for their particle size, polydipersity (PDI), zeta potential, microemulsion morphology, dilution test, conductivity, thermodynamic stability and drug release. Formula F3 was chosen since it exhibits the lowest particle size (11.83 nm ± 0.55 nm), zeta potential -2.57 mV, passed the thermodynamic stability tests and had significantly higher (P < 0.05) release percent for vemurafenib (91% within 24 h). As a conclusion, microemulsion is considered as a poweful and promising drug delivery system for topical administation
Adaptación y validación de una escala de uso tecnológico docente universitario
Authors: López Pérez Gabriel Bernardo , Norzagaray Benítez Claudia Cecilia , Sotelo Castillo Mirsha Alicia , Fraijo Figueroa Jose Alberto
Published: December 2023

La evaluación del uso tecnológico, así como su investigación, es importante para elaborar predicciones sobre aspectos que lo promuevan; por ello, el objetivo de esta investigación es la validación de una escala de uso tecnológico docente a nivel superior. Se empleó una muestra de 69 profesores/as pertenecientes a universidades públicas y privadas del noroeste de México, y se adaptó y validó la escala de Tuapanta et al. (2017). Durante la adaptación del instrumento, se empleó la técnica de traducción inversa y, para la validez de constructo, el análisis factorial exploratorio. Los resultados arrojaron una solución unidimensional, la cual fue sometida a un análisis factorial confirmatorio que constató la estructura con índices de ajuste prácticos y poblacionales adecuados; por último, se analizó la consistencia interna mediante el coeficiente de alpha de Cronbach, que resultó en un puntaje satisfactorio en la escala final. Se concluye que la versión adaptada de la escala es válida y fiable para la evaluación de la realidad del profesorado de nivel superior en México.
Controlling the economic sustainability of agricultural organizations with the help of the agrochemical service
Authors:   D.N. Pryanishnikov Research Institute of Agrochemistry, Moscow, Russia, Vizirskaya Maria M. , Zhdanov Vasily Yu. ,   D.N. Pryanishnikov Research Institute of Agrochemistry, Moscow, Russia
Published: December 2023

The article discusses the formation of a system of controlling the economic sustainability of agricultural organizations with the help of the organization of agrochemical service. The main functions of the relevant department in the context of the organization’s management are determined, as well as the competencies necessary for the service staff are established.
The assessment of investment risks in agriculture in Russia
Authors:   Federal State Budgetary Scientific Institution “Federal Research Center of Agrarian Economy and Social Development of Rural Areas – All-Russian Research Institute of Agricultural Economics”, Moscow, Russia, Maslova Vlada V. , Zaruk Natalya F. ,   Federal State Budgetary Scientific Institution “Federal Research Center of Agrarian Economy and Social Development of Rural Areas – All-Russian Research Institute of Agricultural Economics”, Moscow, Russia, Avdeev Mikhail V. ,   Federal State Budgetary Scientific Institution “Federal Research Center of Agrarian Economy and Social Development of Rural Areas – All-Russian Research Institute of Agricultural Economics”, Moscow, Russia
Published: December 2023

The article is devoted to the problems of formation of investment attractiveness in the context of minimizing investment risks in agriculture in Russia. The authors consider the basic concepts of risk theory, including in agriculture. The researchers proposed methodological approaches to the assessment of investment risks, including the identification of risks, their classification and grouping, calculation and assessment of risks. The assessment of investment risks was carried out by calculating the complex integral indicator determined on the basis of financial, economic and social risks, based on the operation of maximization and double rationing. Based on the approbation of methodological approaches to the assessment of investment risks in agriculture in the context of the regions of the Russian Federation, the authors conducted the ranking and grouping of regions and identified a group of regions with minimal investment risks and extremely high risks. In order to minimize investment risks, the article formulates proposals for improving measures of state regulation and investment policy at the federal and regional levels.
Spatial asymmetry in infrastructure security of non-urbanized territories of the Russian Federation
Authors:   Research Institute for Economics and Organization of Agro-Industrial Complex in the Central Chernozem Region – branch of FSBSI «Voronezh Federal Agrarian Scientific Center named after V.V. Dokuchaev», Voronezh, Russia, Novikova Irina I.
Published: December 2023

The current spatial transformation has led to negative changes in the current conditions of life support of the population, namely, to a decrease in the infrastructure provision of non-urbanized territories. To solve this problem, it is necessary to make an assessment that allows to identify the level of infrastructure development in territories with different degrees of spatial organization. As a result, 4 types of non-urbanized territories were identified: with a high level of infrastructure development and a moderate degree of spatial organization (10 regions); with the highest level of infrastructure development and a significant degree of spatial organization (11 regions); with a satisfactory level of infrastructure development and a low degree of spatial organization (31 regions); with a critical level of infrastructure development and a degree of spatial organization (30 regions). For each type, measures are justified aimed at providing the population with socially significant objects to meet their service needs.
The role of scientific and technological progress in the process of AIC modernization in the context of digital transformation
Authors:   Russian State Agrarian University - MSHA named after K.A. Timiryazev, Moscow, Russia, Vodyannikov Vladimir T. , Eder Alexander V. ,   Company KROC Incorporated, Moscow, Russia
Published: December 2023

Achievements in the scientific field, the improvement of technology in the process of transition to the digital economy are associated with periods of activation of scientific and technological progress. The successes in quantum computing were preceded by many successfully implemented scientific developments that expanded and replenished the volume of scientific knowledge and contributed to the introduction of innovative technologies, substantiated innovative scientific theories that created a new generation of technology, which confirms the relevance of stimulating the modernization of economic sectors, including agriculture. The digital economy as a trend is being implemented in agricultural sectors, for which a digital transformation map is proposed. The article presents the directions of scientific and technological progress that are in demand in the agro-industrial complex in order to improve it, the topic of modernization of the industry on the basis of digitalization is considered. The introduction of intelligent decision support systems in crop production and animal husbandry allows to reduce production costs, save resources, and increase the efficiency of agro-industrial production.
What affects perceived quality? An examination of television fiction series
Authors: Etayo Cristina , Lopes Nuno José , Nichols Elana E.
Published: December 2023

With the number of television series increasing almost daily and resources becoming increasingly sparse, it is more important than ever for companies to determine which series will have market success or not. This paper attempts to identify the characteristics of television fiction series that cause consumers to perceive them as being of high quality. In a nation-wide survey, we surveyed 874 television viewers about ten series from four genres to investigate which characteristics of television series predict consumers’ perception of their quality. Although in most cases the coherence of the plot and the dialogues have a strong and positive effect on perceived quality, overall, we find that different genres have different predictors of perceived quality. We discuss the implications of our findings and provide recommendations for future research and practice.
DECORATIVE AND APPLIED CREATIVITY AS A MEANS OF FORMING THE CREATIVE SKILLS OF HIGH SCHOOL STUDENTS
Authors:   Полтавський національний педагогічний університет імені В. Г. Короленка, KIS A.
Published: December 2023

The article considers the importance of using decorative and applied creativity for the formation of creative abilities of high school students. Various forms of decorative and applied creativity are mentioned, including embroidery and carpet making. It has been revealed how pedagogical methods can be applied to involve high school students in these types of creativity. Among these methods are the creation of creative laboratories, conducting master classes and the use of interactive teaching methods. The importance of a scientifically based approach to the use of decorative and applied creativity as a tool for the formation of students' creative abilities is emphasized. It is emphasized that this approach can have a positive effect on various aspects of personality, such as creativity, self-expression, self-discipline and the development of critical thinking. Accordingly, the use of decorative and applied creativity can be important for the preparation of high school students for future professional activities and the development of their creative abilities. In addition, the importance of the use of information and communication technologies in the development of creative abilities of high school students was revealed. After all, they make it possible to create new opportunities for creativity and innovation, and also provide the opportunity to use modern tools and technologies to achieve the goal. Using online courses and webinars can be a great tool for students who want to develop their creativity and find new ideas for their projects. Thus, the article emphasizes the importance of developing the creative abilities of high school students and provides specific tips and methods for their stimulation. The use of arts and crafts and ICT can be an important step in the formation of students' creative abilities and help them develop in the direction of choosing a future profession. Keywords: decorative and applied creativity, creative abilities, high school students, formation, development.
DIGITAL STORYTELLING AS A TOOL FOR SOCIO-EMOTIONAL COMPETENCIES DEVELOPMENT IN THE ENGLISH LANGUAGE CLASSROOM
Authors:   Бердянський державний педагогічний університет, SALIUK B. , SHKOLA I. ,   Бердянський державний педагогічний університет
Published: December 2023

The modern educational environment actively integrates social-emotional learning (SEL) to promote social adaptation, ethical culture, and emotional development of students. This article considers the method of digital storytelling as a tool for the formation of social-emotional competencies of students during English classes. The article examines social-emotional competencies, known as CASEL5, which are self-awareness, self-management, relationship skills, responsible decision-making, and social awareness. At the same time, the analysis of the standards for basic and full general secondary education in Ukraine (2011 and 2020) proved the productivity of the linguistic and literary educational field in the integration of social-emotional learning, where the use of the storytelling method, in particular digital, enables the formation of key social-emotional competencies of students. The method of digital storytelling is implemented through various online platforms and related tasks. For example, creating comics appears as a visualization of complex stories, which helps students improve not only SEL competencies but also foreign language communicative competence, creativity, and digital literacy. This goal is also facilitated by the use of online cubes for storytelling, and emojis. The article also highlights AI-enabled online books as a tool for social-emotional learning. The Storybooks platform generates online books at the user's request. The generated stories are aligned with social-emotional learning themes and end with questions that stimulate discussion among students, thus encouraging them to think critically and reflect. The study found that digital storytelling serves as a powerful channel for students to express emotions, empathy, improve their ethical skills and social responsibility. This method develops a constructive dialogue, the articulation of thoughts and beliefs, as well as the visualization of universal values and life experience, and thus contributes to the holistic development of students’ socio-emotional competencies. Keywords: digital storytelling, socio-emotional learning, socio-emotional competence, English language classes.
PEDAGOGICAL CONDITIONS FOR THE DEVELOPMENT OF COMPOSITIONAL AND FIGURATIVE THINKING OF 5TH-6TH GRADE STUDENTS BY MEANS OF MODELING AND SKETCHING WHEN TEACHING CONSTRUCTION MATERIALS PROCESSING TECHNOLOGIES
Authors:   Полтавський національний педагогічний університет імені В. Г. Короленка, SOTNYCHOK O.
Published: December 2023

The article examines the pedagogical conditions for the development of compositional thinking of 5th-6th grade students by means of modeling and sketching in the teaching of construction materials processing technologies. The problem of developing the creative potential and aesthetic competence of students in the learning process becomes especially relevant in the conditions of the modern educational environment, where great emphasis is placed on the development of creative thinking and practical skills. It has been found that compositional and figurative thinking is a key component in the process of professional growth of students of construction materials processing technology. The use of modeling and sketching allows students to creatively approach the solution of technical problems, promotes the development of aesthetic perception and analytical skills. The role of layout as a means of visualizing an idea and structuring the concept of material processing is outlined. Mock-ups allow students to test and refine their ideas before moving on to practical production. In particular, they help to evaluate the appearance and functionality of the future product, detect possible defects in advance and help to eliminate them. The importance of sketches as a tool for creative search and self-expression is also considered. Sketches help students create model drawings, which are the basis for further creation of the product. Using them allows students to focus on details and maintain the necessary proportions in their projects. In the context of learning technologies for processing construction materials for students of grades 5-6, it was found that compositional thinking is an essential aspect that contributes to the formation of their creative abilities and the development of imagination and critical thinking. In particular, it is stated that the ability of students to understand the connections between elements and the ability to create artistic compositions from materials are key in the process of processing materials. Keywords: compositional and figurative thinking, modeling, sketching, construction materials processing technology, labor training, 5-6 grade students, creativity, pedagogical conditions, psychological and pedagogical aspects.