bluuebunny/crossref_metadata_2025 huggingface dataset:
The Population of Airborne Microorganisms and the Presence of Staphylococcus aureus in Cattle Farm at Ladang Pasir Akar
Authors: Nur Syuhada Ahmad Nordin  , Azman Azid  , Fathurrahman Lananan  , Mohd Saiful Samsudin  , Najmi Wahidi Ab Wahab
Published: November 2020

Microorganisms found in bio aerosols from animals’ confinement buildings is not only foster the risk of spreading diseases among livestock itself, but also pose health hazard among farm workers and nearby residents. The objectives of this study are to observe the population of microorganisms and identify the present of Staphylococcus aureus (S. aureus) inside the cattle farm. DRF e-MAS which was owned prepared by Arduino kit had been used to observe the microorganisms’ population. The air from surrounding that contained microorganisms being aspirated into the plate chamber of the DRF e-MAS. The nutrient agar that being placed inside the plate chamber will be incubated along with aspirated microorganisms and the result of microorganisms’ population will be observed. S. aureus is one of the possible bacteria that may be found among the population of the microorganisms in cattle farm. DRF e-MAS along with Baird Parker Agar being used to identify the present of S. aureus. Baird Parker Agar is used to enhance the growth of S. aureus while eliminating the others. After being incubated, a single colony of S. aureus that grew on the Baird Parker Agar had been picked and regrow on another nutrient agar. A single colony that formed on that nutrient agar will be picked and then undergo Coagulase test and IMViC test. Coagulase test involved the citrated plasma and the present of bubbles show positive result. On the other hand, IMViC test divided into four sub-test which are Indole test, Methyl red test, Voges-Proskauer test and Citrate test.  These tests are important in order to confirm the present of S. aureus in this farm. According to the test, there was S. aureus found among the microorganisms’ population inside this barn.
Effects of Probiotic (Lactobacillus spp) Mixed with Cassava Leaves (Manihot esculenta) on Growth Performances and Meat Quality of Cherry Valley Duck (Anas platyrhynchos domesticus)
Authors: Nur Al Syifaa Hassan  , Connie Fay Komilus
Published: November 2020

Probiotics are beneficial bacteria that had been used in poultry industry as alternative sources for antibiotic. The aim of this study was to determine the effect of probiotic mixed with cassava leaves (Manihot esculenta) on Cherry Valley Duck (Anas platyrhynchos domesticus) growth performance, carcass characteristics and meat quality. Lactobacillus spp. was used in this experiment to see its effectiveness in enhancing quality of cassava leaves as potential feed towards optimum growth performance of ducks like body weight gain, feed intake and feed conversion ratio, carcass characteristics and meat quality. 34 tails of Cherry Valley ducks aged 14 days with average weight of 500 g were randomly assigned to four treatments in triplicates. Treatments for the 35 days feeding trial were T1 at 0% probiotic + 75% commercial diet + 25% cassava leaves (control), T2 (0.15% probiotic + 75% commercial diet + 25% cassava leaves), T3 (0.30% probiotic + 75% commercial diet + 25% cassava leaves) and T4 (0.45% probiotic + 75% commercial diet + 25% cassava leaves) respectively. Proximate analysis was also conducted to determine nutritional content like protein, lipid, moisture, ash and fiber. Results show that supplementation of probiotic at 0.15% Lactobacillus spp. into 25% of cassava leaves and 75% commercial pellet gave highest body weight gain (BWG), low feed conversion ratio (FCR), highest carcass yield and good meat quality. It can be concluded that inclusion of probiotic at 0.15% in cassava leaves as duck’s diet gives good growth performance and may become an alternative super diet for duck in future.
Effect of Salt Addition on Mass Transfer, Colour and Texture Characterictics of Shallow Fried Potato Strips
Authors: Rabi'ah Fathullah  , Nor Haizum Mat Rashid  , Wan Mohd Fadli Wan Mokhtar  , Wan Anwar Fahmi Wan Mohammad
Published: November 2020

Shallow frying is widely used as one of the cooking processes because of its simplicity and ability to gives better taste of foods by adding spices, herbs and salt. Despite its widespread use, the mass transfer and product properties of shallow frying have not been studied systematically, especially after the addition of salt. This study aims to investigate the effect of adding salt to potato strips, prior to shallow frying on the mass transfer (moisture and oil contents) and physical properties (colour and texture) of products. The potato strips were cut into 9 x 9 x 50 mm and were divided into salted (1% w/w) and unsalted (as control), and then were shallow fried at 150°C and 180°C for 35 minutes. The moisture and oil contents were analysed every 5 minutes, while colour and texture were determined at the end of shallow frying (i.e. when moisture content reached ~0.82 kg H2O/kg dry matter). Salted fried potato at 180°C resulted in a significantly shorter frying time of 18 minutes, compared to unsalted fried potato, which took 21 minutes. Meanwhile, at 150°C, the frying time reduced to 25 minutes for the salted product from 33 minutes under unsalted product. The oil content, colour and texture of final products were not significantly different under both treatments. Therefore, the effect of adding salt to potato strips does not influence the oil content, colour and texture of the shallow fried products, but reduces frying times by up to 24%, thereby improving energy efficiency.
On the Sums Running over Reduced Residue Classes Evaluated at Polynomial Arguments
Authors: Hassani Mehdi , Marie Mahmoud Marie
Published: November 2020

For a given polynomial G we study the sums φm(n) := ∑′km and φG(n) = ∑′G(k) where m ≥ 0 is a fixed integer and ∑′ runs through all integers k with 1 ≤ k ≤ n and gcd(k, n) = 1. Although, for m ≥ 1 the function φm is not multiplicative, analogue to the Euler function we obtain expressions for φm(n) and φG(n). Also, we estimate the averages ∑n≤x φm(n) and ∑n≤xφG(n), as more as, the alternative averages ∑n≤x(−1)n−1φm(n) and ∑n≤x(−1)n−1φG(n).
COMPONENTS OF SUSTAINABLE DEVELOPMENT OF REGIONAL SOCIO-ECONOMIC SYSTEMS
Authors: Timofeev Roman Andreevich , Yachmenev Evgeny Fedorovich , Timaev Ruslan Abdurashidovich
Published: November 2020

The article identifies the main problems of sustainable development of modern Russian society (quality of life, demography, spatial development, welfare of the population, etc.). The key subsystems of sustainable development of regional socio-economic systems (economic, social, environmental, institutional) are analyzed. The role and significance of the institutional subsystem in the sustainable development of regional socio-economic systems is substantiated. The main reasons for the instability of the institutional subsystem of regional development are identified and a number of measures that need to be taken to improve the efficiency of the domestic economy are indicated. The author’s definition of the category “sustainable development of regional socio-economic systems” is presented. Based on the analysis, a graphical model of the interaction of key subsystems of sustainable development of the region is built. Based on the author’s interpretation of the classical production function, a functional dependence of the sustainable development of the regional socio-economic system on the combination of factors of key subsystems is proposed.
АНАЛИЗ СЕТЕВОГО ОНКО-ДИСКУРСА ТРЕХЛЕТНЕЙ РЕТРОСПЕКТИВЫ В ДОМЕНЕ ВЕРХНЕГО УРОВНЯ RU
Authors: Духанина Л. , Максименко А.
Published: November 2020

В настоящей статье дается глубокий анализ тем русскоязычного сегмента социальных медиа, которые связаны с государственной поддержкой противодействия и профилактики онкологических заболеваний. На основе количественного и качественного анализа неструктурированных данных онко-дискурса с ретроспективой с 2016 по 2019 гг. С последующим выделением наиболее резонансных событий, нашедших свое отражение в еоциальных русскоязычных медиа, выделены основные категории инфоповодов за весь период исследования, а также названы наиболее активные и авторитетные авторы, принимающие участие в распространении темы с учетом геолокации распространения тематических сообщений, анализа источников и площадок распространения тематических публикаций.
Nocarimidazoles C and D, antimicrobial alkanoylimidazoles from a coral-derived actinomycete Kocuria sp.: application of 1JC,H coupling constants for the unequivocal determination of substituted imidazoles and stereochemical diversity of anteisoalkyl chains in microbial metabolites
Authors: Karim Md Rokon Ul , Harunari Enjuro , Sharma Amit Raj , Oku Naoya , Akasaka Kazuaki , Urabe Daisuke , Sibero Mada Triandala , Igarashi Yasuhiro
Published: November 2020

Chemical investigation of secondary metabolites from a marine-derived actinomycete strain of the genus Kocuria, isolated from a stony coral Mycedium sp., led to the identification of two new alkanoylimidazoles, nocarimidazoles C (1) and D (2) as well as three known congeners, nocarimidazoles A (3) and B (4) and bulbimidazole A (5). Structure analysis of 1 and 2 by NMR and MS revealed that both are 4-alkanoyl-5-aminoimidazoles with a 6-methyloctanoyl or decanoyl chain, respectively. Two possible positions of the amino group on the imidazole rings (C-2 and C-5) posed a challenge in the structure study, which was settled by the measurement of 1JC,H coupling constants for comparison with those of synthetically prepared model imidazoles. The absolute configurations of the anteisoalkanoyl group present in 1, 4, and 5 were determined by low-temperature HPLC analysis of the degradation products labeled with a chiral anthracene reagent, which revealed that 1 is a mixture of the R- and S-enantiomers with a ratio of 73:27, 4 is the pure (S)-enantiomer, and 5 is the (S)-enantiomer with 98% ee. The present study illustrates the diversity in the stereochemistry of anteiso branching in bacterial metabolites. Compounds 1−4 were moderately antimicrobial against Gram-positive bacteria and fungi, with MIC ranges of 6.25–25 μg/mL.
Pengaruh Profitabilitas, Ukuran Perusahaan, Debt Default dan Audit Tenure terhadap Opini Audit Going Concern
Authors: Suryani Suryani
Published: November 2020

Going concern audit opinion is an opinion given by an independent auditor to a company when doubts are found whether the company can maintain its business continuity in the future. This study aims to analyze the effect of profitability, company size, debt default, and audit tenure on going concern audit opinion. The population used in this study were 170 manufacturing companies listed on the Indonesia Stock Exchange for the period 2015-2019 by using the purposive sampling method, obtained a sample of 43 companies that have met the sample selection criteria. The method of analysis used is logistic regression with a significant level of 5% (0.05) and using an analysis tool in the form of SPSS version 20.0. The results showed that profitability and firm size had a negative effect on going concern audit opinion, debt default had a positive effect on going concern audit opinion, while audit tenure had no effect on going concern audit opinion.
Közrendészeti magánbiztonság és magánrendészet közpénzből
Authors: Tóth Judit
Published: November 2020

The author provides an overview of how recent legislative developments on police, security and law enforcement have formed in constitutional issues in Hungary.
Yangian of the General Linear Lie Superalgebra
Authors:   University of York, UK, Nazarov Maxim
Published: November 2020

We prove several basic properties of the Yangian of the Lie superalgebra gl(M|N).
A QFT ROBUST CONTROLLER AS A REMEDY FOR TRMS
Authors: Honari-Torshizi Mostafa , Rahmani Hossein , Moeinkhah Hossein , Gharib Mohammad Reza , Jahanpour Javad
Published: November 2020

Control of a Twin Rotor Multi-input Multi-output System (TRMS) is not a simple work. Because it has complex nonlinear dynamics, cross-coupling, uncertainties, and instability. This paper provides a practical method for control of a TRMS, named Quantitative Feedback Theory (QFT) as one of the robust approaches. Firstly, the TRMS set and modeling procedure are introduced. Secondly, the nonlinear and linear equations of electrical and mechanical parts in both vertical and horizontal planes are presented. Next, using the QFT method, a controller is designed for motion in each plane. Finally, the robustness of the control strategy is illustrated by simulations of vertical and horizontal motions, including controller and pre-filter in the presence of uncertainties. The results demonstrate that the proposed robust controller can guarantee the system stabilization, as well as pitch and yaw tracking of TRMS.
THE GUATEMALAN CONSTRUCTION CHARACTERIZATON OF THE PERCEIVED RISK BY MANAGERS OF SUFFERING WORK ACCIDENTS
Authors: Hernández-Arriaza Francisco Arturo , Pérez-Alonso José , Gómez-Galán Marta , Salata Ferdinando , Callejón-Ferre Ángel Jesús
Published: November 2020

The construction industry is considered one of the highest risk production sectors, even more so in developing countries such as Guatemala. A characterization has been carried out on the perception of Guatemalan construction company managers regarding, the risk of accidents exist for the different activities they perform. The characterization has been carried out on a representative sample of the business population via a questionnaire. A preliminary data analysis was performed followed by a Descriptive and a Multiple Correspondence Analysis. Companies are characterized as “mediumsize” companies, with an average of 81.1 construction workers per year and average annual turnover of 1.29 million euros. 4 clusters of construction activities occur with similar accident weightings. Companies in Cluster 1 are associated to the variables grouped with a Low risk weighting, with a medium to high number of on-site workers and with a turnover of more than 100,000 euros. In contrast, those in Cluster 2 are associated with the variables grouped as having a Medium risk weighting, with a low number of on-site workers and a turnover of less than 100,000 euros. The companies in Cluster 3 are only associated with High risk weighted. And those of Cluster 4 with Not applicable risk-weighting variables.
THE IMPACT OF THE INTERNATIONAL CONSTRUCTION STANDARD APPLICATION CAPABILITY ON CONTRACTORS’ COMPETITIVENESS: CHINESE CONTRACTORS’ EXPERIENCE
Authors: Ma Dingyuan , Li Xiaodong , Cheng Chen
Published: November 2020

The application capability of international construction standards (ICS) has become a necessary element for the success of contractors in the international market. However, there is a lack of quantitative analysis of the impact of ICS application capability on contractors’ competitiveness. This paper aims to explore the driving paths between them. The authors divided the competitiveness indicators into market performance indicators and image performance indicators and developed a standard application capability measurement scale based on five dimensions (knowledge learning, talent guarantee, technical support, relationship management and organization guarantee). Then, a structural equation model (SEM), in which project performance was regarded as a mediator variable, was established to investigate the path and intensity of ICS application capability on contractors’ competitiveness. A questionnaire was distributed to the project personnel of Chinese contractors engaged in international projects, and 174 valid questionnaires were collected. The results show that 1) relationship management and technical support have a direct driving effect on the competitiveness of contractors; 2) talent guarantees and organization guarantees affect contractors’ competitiveness through project performance. This study can remind contractors of the importance of the ICS application capability and the weakness of ICS application. Additionally, it will ultimately help contractors adjust their competitiveness strategies.
DEVELOPMENT OF K-BIM E-SUBMISSION PROTOTYPICAL SYSTEM FOR THE OPENBIM-BASED BUILDING PERMIT FRAMEWORK
Authors: Kim Inhan , Choi Jungsik , Teo Evelyn Ai Lin , Sun Hongwei
Published: November 2020

With the popularization of Building Information Modeling (BIM) technology, increasing numbers of countries are attempting to introduce BIM into their national building permitting processes. There are also many BIM-related research initiatives worldwide. Likewise, the Korean government has joined this trend by improving its existing e-Submission system, SEUMTER, to provide for BIM-based e-submission and automated code compliance checking. Further, the Ministry of Land, Infrastructure, and Transport in Korea has funded the Korea BIM (KBIM) building e-Submission system project. The Industry Foundation Classes (IFC) data model is an openBIM approach that has been designated as an international standard through the International Organization for Standardization. It is not dependent on specific design tools and is suitable for public works applications. Hence, this study performed a comprehensive analysis of and developed a framework for a prototypical system for an e-Submission process based on the IFC data model. Four main modules were developed to perform code checking, submission, pre-checking, and automated rule-making. A real-world project was used to verify the feasibility and effectiveness of the proposed framework. This study could increase the adoption of BIMbased building e-Submission systems by sharing effective and successful processes.
Relationship between Plasma Neuregulin-1 and MDA Levels with Severity of CAD
Authors: Aliska Gestina , Fadil Muhammad , Ilhami Yose Ramda , Usman Elly , Raditya Ivan Mahendra , Zhuhra Rahma Tsania , Alfadli Robby
Published: November 2020

BACKGROUND: Neuregulins (NRGs) are one of the epidermal growth factors (EGF) superfamily, which released in cellular injuries, such as neurons and myocardial cells. Neuregulin-1β (NRG-1β) could be activated when stress happens to myocardial cells, acting as a survival factor to repair the injury. Malondialdehyde (MDA) is also produced during oxidative stress in cardiac injury. In vivo study of myocardial cells in rats and dogs that got ischemic, dilated, and viral cardiomyopathy showed that NRG-1 could improve the injured cardiac performance, attenuated pathological changes, and prolonged survival of the cells.
AIM: We aimed to observe NRG-1 levels in CAD patients in Indonesia, mainly focused in Minang ethnicity. This study also analyzes the relationship between NRG-1 and MDA with CAD’s severity.
METHODS: We measured plasma NRG-1 in 61 nondiabetic patients within 38–82 years old range with STEMI, NSTEMI, and UAP.
RESULTS: We found their plasma NRG1, respectively, was 10.3 (1.9–38.2) ng/ml, 14.3 ± 7.2 ng/ml, and 7.05 (4.5–0.4) ng/mL. Plasma NRG 1 increased in AMI patients.
CONCLUSION: This study concludes that NRG1’s activated during cardiac cells injury, in any AMI.
Checklist of herpetofauna in the severely degraded ecosystem of Bidong Island, Peninsular Malaysia, South China Sea
Authors: Fatihah-Syafiq Muhamad , Badli-Sham Baizul Hafsyam , Fahmi-Ahmad Muhammad , Aqmal-Naser Mohamad , Rizal Syed Ahmad , Azmi Mohd Shahrizan Azrul , Grismer Larry L. , Ahmad Amirrudin B.
Published: November 2020

A herpetofaunal inventory was conducted on Bidong Island, Terengganu, Peninsular Malaysia. It incorporates data from a recent herpetological survey conducted from 1 to 3 April 2019 with reptile records from previous publications. Specimens were collected with drift-fenced pitfall traps and taxa were recorded with visual encounter surveys (VES). In total, 18 species of reptiles and amphibians were recorded, including three species of frogs, 12 species of lizards, and three species of snakes. Six species from the present survey are new records for the island.
Description of a new Megophrys Kuhl & Van Hasselt, 1822 (Anura, Megophryidae) from Guizhou Province, China
Authors: Li Shi-Ze , Lu Ning-Ning , Liu Jing , Wang Bin
Published: November 2020

A new species of the genus Megophrys is described from Guizhou Province, China. Molecular phylogenetic analyses based on mitochondrial DNA indicated the new species as a clade clustered into the Megophrys clade. The new species can be distinguished from its congeners by a combination of the following characters: body size moderate (SVL 40.0–45.5 mm in males and 48.9–51.2 mm in females); vomerine teeth absent; tongue not notched behind; tympanum distinctly visible, oval; a small horn-like tubercle at the edge of each upper eyelid; two metacarpal tubercles in hand; toes with rudimentary webbing; heels overlapping when thighs are positioned at right angles to the body; tibiotarsal articulation reaching the level of mid-eye when leg stretched forward; in breeding males, an internal single subgular vocal sac present and brownish nuptial pads, made up of black nuptial spines, present on the dorsal base of the first two fingers.
Role of asymptomatic hyperuricemia in the progression of chronic kidney disease and cardiovascular disease
Authors: Waheed Yousuf , Yang Fan , Sun Dong
Published: November 2020

Previous research has investigated whether hyperuricemia serves as an independent risk factor for cardiovascular and renal diseases. Hyperuricemia is defined as an abnormally high level of uric acid (UA; i.e., serum urate level > 6.8 mg/dL). Hyperuricemia has been considered a complication of chronic kidney disease (CKD). However, it seems to play a pathogenic role in the progression of renal diseases. There has been increasing focus on the link between hyperuricemia and CKD. The results of randomized controlled trials have implied independent associations between hyperuricemia and the progression of cardiovascular and renal morbidities. These associations may be mediated by renin-angiotensin system activation, nitric oxide synthase inhibition, and macrovascular/microvascular disease development. There remains controversy regarding the use of serum UA level as an indirect index of renal vascular disease. This literature review focuses on the role of asymptomatic hyperuricemia in the progression of CKD, as well as the association between hyperuricemia and cardiovascular disease. It also provides a general overview of the physiological metabolism of UA.
The optimal anti-phospholipase A2 receptor cutoff for the diagnosis of idiopathic membranous nephropathy: a single-center retrospective study
Authors: Li Chaofan , Li Ping , Guo Wenkai , Chen Lei , Li Jiatong , Wang Rong , Chen Bing
Published: November 2020

Background/Aims: Anti-phospholipase A2 receptor (PLA2R) autoantibody is the main biomarker of idiopathic membranous nephropathy (IMN). We aimed to find a new cutoff value of anti-PLA2R for patients with IMN and to explore the relevance between this antibody and baseline clinical parameters.Methods: A total of 670 subjects including 374 IMN cases and 296 non-IMN controls were included between January 2017 and January 2020. All clinical parameters were collected at the time of renal biopsy. The levels of anti-PLA2R were detected by a commercial enzyme-linked immunosorbent assay (ELISA) kit. The optimal cutoff value was calculated by a receiver operating characteristic curve and compared in diagnostic efficiency.Results: The optimal cutoff value of anti-PLA2R for IMN was 7.45 RU/mL with the highest Youden index, and the corresponding sensitivity, specificity, positive predictive value and negative predictive value were 80.75%, 97.97%, 98.05% and 80.11%, respectively. Anti-PLA2R levels in IMN patients demonstrated a significant positive correlation with serum creatinine and 24-hour urinary protein, while they showed a negative correlation with serum albumin and estimated glomerular filtration rate.Conclusions: The recommended cutoff value of anti-PLA2R is 7.45 RU/mL using ELISA detection for distinguishing IMN from non-IMN nephropathy. The level of anti-PLA2R is related to baseline renal function in IMN. This new threshold can improve the diagnostic efficiency and facilitate early diagnosis of IMN.
Balzac, les Secondes Lumières
Authors: David Jérôme
Published: November 2020

Il s’opère en France, entre les années 1830 et 1860, une révolution invisible dans le roman, l’histoire et les enquêtes sociales, les sciences naturelles ou la psychopathologie. L’établissement de la vérité, en réaction à la menace d’une guerre civile nourrie par l’imaginaire de la Terreur, n’y engage plus un accès privilégié de quelques-uns à la « chose en soi », mais la participation de quiconque à la connaissance de ce qui, dans la réalité, mérite examen et action. Le langage devient l’arrière-plan commun de cet appariement des expériences, de cette compossibilité espérée du présent. La Comédie humaine en est le versant littéraire. Between 1830 and 1860, an unseen revolution was taking place in France, affecting the novel, history, social analyses, the natural sciences and psychopathology. The establishment of truth as a reaction against the threat of a civil war feeding on memories of the Terror no longer enables some to have privileged access to the “thing in itself” but allows everyone access to knowledge of what, in reality, warrants examination and action. Language thus provides the shared background for the development of experiences and for the hoped-for collective potentiality of the present. La Comédie humaine is the literary incarnation of this revolution.
Relire Le Cousin Pons à la lumière de Tocqueville
Authors: Dufour Philippe
Published: November 2020

Balzac s’interroge dans La Comédie humaine sur les principes et les valeurs de la société démocratique issue de la Révolution française, comme au même moment Tocqueville dans De la démocratie en Amérique . On établit ici un dialogue entre le roman et l’essai dans leur pensée de la démocratie, autour de grands traits définitoires (mobilité, médiocrité, humanité), tout en privilégiant pour Balzac l’œuvre dernière, Le Cousin Pons , quand le monde des possibles dessiné par Tocqueville laisse place à un univers figé et désenchanté.
Cancérologiquement correct
Authors: Derzelle Martine
Published: November 2020

Une certaine conception du langage s’est progressivement imposée sur le plan institutionnel et dans la littérature scientifique pour produire une vision univoque de la santé : véritable « police des mots », elle emploie le détour de mots d’ordre, de slogans, de stéréotypes et de sentences péremptoires. La cancérologie, les soins palliatifs et la douleur (chronique) en sont des déclinaisons paradigmatiques. Ce qui disparaît dans cette opération langagière, c’est tout à la fois le négatif constitutif de la pensée en même temps que la place faite à l’irréparable, à l’irréductible. Ce qui disparaît en dernière analyse, c’est l’homme « ontologique » au point d’être sommé même, dans des versions extrêmes, de « réussir sa mort », telle une performance. Notre hypothèse est que c’est d’un « colmatage » dont il s’agit : en un temps de « malaise dans la symbolisation », où prévaut une retraduction par la logique technologique et gestionnaire, les énoncés de la pensée « commune » colmatent le vide. Comme si, ayant tout perdu, nous n’avions plus que « ce peu de mots pour trouver du commun ». Reste à s’interroger sur l’éventuel effet d’aliénation de ce discours chez tous ceux qui s’y trouvent exposés (patient, soignant, proche).
Pratique psychosomatique en psychiatrie
Authors: Benssoussan Maurice
Published: November 2020

À partir d’une approche générale de la psychosomatique et de son évolution dans le champ de la psychiatrie, des incidences concrètes pour une pratique de la psychosomatique en psychiatrie sont esquissées à partir du concept de « psychosomatique relationnelle » développé par Sami-Ali. L’auteur présente une psychiatrie relationnelle dont la pratique concerne l’ensemble des soignants du champ de la santé mentale et de la psychiatrie.
Le rêve traumatique, l’affect et le jeu dans la thérapeutique des dépendances psychiques
Authors: Contant Maurice , Calza André
Published: November 2020

Dans cet exposé, il s’agira de s’aventurer dans l’exploration théorico-clinique des pathologies des souffrances narcissiques qui ont des incidences sur l’organisation du sentiment même d’identité. Le rêve, l’affect et le jeu seront des moyens de pointer la contradiction qui est à l’œuvre dans ces situations cliniques, mais aussi de rassembler les différents éléments de l’impasse. Ils permettront aussi de mettre en place la problématique du double, préalable indispensable à la construction identitaire à partir de la découverte de l’altérité et de la fonction réflexive du sujet. À partir de deux illustrations cliniques, nous mettrons à l’épreuve nos hypothèses élaborées grâce aux travaux de Sami-Ali et Winnicott.
Les différents champs d’expression en art-thérapie relationnelle
Authors: Al-Husseini Leila
Published: November 2020

À partir de quelques cas thérapeutiques, il s’agit d’interroger le dispositif de l’art-thérapie relationnelle et ses différents champs et modalités. Il est question de montrer que la relation thérapeutique ici, à travers la peinture, le collage et l’écriture qui en découle, convoque entre autres, la mémoire de la peau et peut libérer ainsi les affects refoulés et l’imaginaire.
Plasmodium yoelii Uses a TLR3-Dependent Pathway to Achieve Mammalian Host Parasitism
Authors: Keswani Tarun , Delcroix-Genete Delphine , Herbert Fabien , Leleu Ines , Lambert Claire , Draheim Marion , Salome-Desnoulez Sophie , Saliou Jean Michel , Cazenave Pierre-André , Silvie Olivier , Roland Jacques , Pied Sylviane
Published: November 2020

Malaria is associated with complicated immunopathogenesis. In this study, we provide evidence for an unexpected role of TLR3 in promoting the establishment of Plasmodium yoelii infection through delayed clearance of parasitemia in wild type C57BL/6jRj (B6) compared with TLR3 knockout mice. In this study, we confirmed an increased expression of Tlr3, Trif, Tbk1, and Irf7/Irf3 in the liver 42 h postinfection and the initiation of an early burst of proinflammatory response such as Ifng, NF-kB, and Tnfa in B6 mice that may promote parasite fitness. Interestingly, in the absence of TLR3, we showed the involvement of high IFN-γ and lower type I IFN response in the early clearance of parasitemia. In parallel, we observed an increase in splenic NK and NKT cells expressing TLR3 in infected B6 mice, suggesting a role for TLR sensing in the innate immune response. Finally, we find evidence that the increase in the frequency of CD19+TLR3+ B cells along with reduced levels of total IgG in B6 mice possibly suggests the initiation of TLR3-dependent pathway early during P. yoelii infection. Our results thus reveal a new mechanism in which a parasite-activated TLR3 pathway promotes blood stage infection along with quantitative and qualitative differences in Ab responses.
Angiotensin II Type 2 Receptor Modulates Synovial Macrophage Polarization by Inhibiting GRK2 Membrane Translocation in a Rat Model of Collagen-Induced Arthritis
Authors: Wang Xinming , Tu Jiajie , Jiang Ji , Zhang Qiaolin , Liu Qi , Körner Heinrich , Wu Jingjing , Wu Huaxun , Wei Wei
Published: November 2020

The chronic inflammatory autoimmune disease rheumatoid arthritis (RA) is characterized by an infiltration of activated proinflammatory immune cells into the joint that is accompanied by an overproduction of various mediators, leading to destruction of cartilage and bone erosion. Angiotensin II type 2 receptor (AT2R) is involved in antioxidative, anti-inflammatory, and antifibrotic responses. Synovial macrophages (SMs) are a type of tissue macrophages that are derived from bone marrow cells. SMs plays a central role in synovial regional immunization, which is significantly increased in both collagen-induced mice with arthritis mice and RA patients. AT2R activation caused a reversal of the polarization of SMs in the joint from the proinflammatory M1 SM to the tolerogenic, benign M2 SM. In consequence, this switch resulted in an attenuated form of the joint pathology in a rat model of collagen-induced arthritis. These results were mechanistically linked to the observation that GRK2 was translocated into cytoplasm, and ERK1/2 and NF-κB activation were inhibited. These findings open the way to a new therapeutic approach using an activation of AT2R to subvert joint inflammation in RA.
Lymphedema resulting from filariasis successfully treated by surgery
Authors: Kasim Karlina N. , Wahab Siswanto , Djawad Khairuddin , Waspodo Nurelly N. , Mulawardi Mulawardi
Published: November 2020

Filariasis is an infectious disease caused by a filarial worm infection transmitted by mosquito bites. The disease can result in reduced work productivity, disability and social stigma. This disease transmission process begins when a mosquito bite and suck the blood containing the microfilaria. Filarial infections have been grouped into three categories based on their location diseases of the disease: (1) lymphatics, (2) skin, and (3) body cavities. Morbidity is almost entirely due to the species that cause lymphatic diseases, and skin diseases to a lesser degree. A 28-year-old male came with a chief complaint of swollen right leg since four years ago which worsened in the last three months. Upon physical examination, edema, fibrosis, and hyper-pigmented plaques were present on the right lower extremity. The blood microfilariae examination was positive for Wuchereria bancrofti. The lymphedema did not resolve despite of antifilarial treatment and surgery was eventually performed to resect the fibrous tissue and subcutaneous edema. The patient responded well to the treatment with a significant reduction in the edema. No complication was present until two years after surgery.
Questioni di legittimità giuridica e di liceità dell’atto medico in materia di fecondazione “assistita”
Authors: Bucci L.M. , Ventura F. , Ventura A. , Celesti R.
Published: November 2020

Anche solo l’analisi dei testi giuridici fondamentali (Costituzione, Codice Civile, Codice Deontologico) porta già con sé la natura illegittima della fecondazione artificiale medicalmente assistita, a causa della sua carenza nel rispetto fondamentale di altre due categorie giuridiche tra tutte le più importanti: la persona fisica e la famiglia. Ne deriva una sostanziale critica di fondo ora più ora meno severa alle pratiche in uso, ai fini di suggerire linee di pensiero per lo “ius condendum” in tale materia. Le osservazioni etiche che riportiamo in questo nostro lavoro non hanno pretesa di completezza, ma mirano ad evidenziare come esse possano derivare a partire dai testi giuridici stessi (e quindi dallo “ius conditum”) e possano fare da guida al legislatore, diminuendo il rischio (peraltro elevato all’atto pratico) di una legislazione particolare che diventi qua e là contraddittoria con principi giuridici fondamentali, reperibili come capisaldi nel diritto più classico.
Il dibattito in bioetica - Cooperazione allo sviluppo e sapere bio-medico. Per un’etica sociale della medicina
Authors: Mottini G.
Published: November 2020

Non disponibile.
Le conseguenze psicologiche derivanti dall’interruzione volontaria della gravidanza: i risultati di alcune ricerche
Authors: Genovese Claudia
Published: November 2020

Il contributo porta sinteticamente a conoscenza i risultati di alcune ricerche, condotte in diversi paesi, sul disagio post-abortivo. Sensi di colpa, idee autolesioniste, depressione, abuso di alcool o stupefacenti, disturbi del comportamento, ipervigilanza, “sindrome dell’anniversario” sono solo alcuni tra i sintomi osservati.

I dati emergono da studi conformi alla metodologia dell’indagine psicologica e non appaiono pertanto condizionati dall’approccio alla problematica dell’aborto.

Se ne traggono conclusioni circa le strategie preventive del ricorso all’interruzione volontaria della gravidanza e circa il ruolo assegnato al pericolo per la salute psichica della donna dalla legislazione in materia di aborto. Tale pericolo risulta invero fondatamente riscontrabile, alla luce dei dati raccolti, proprio laddove un’interruzione volontaria della gravidanza venga effettuata. Ciò conduce a esprimere il convincimento che gli interessi del concepito e della madre rispetto alla gravidanza non siano in contrapposizione, ma in stretta, reciproca correlazione.
Il dibattito in bioetica - Ciber-psicopatologie e ciber-psicoterapie
Authors: Tartaglione Sergio
Published: November 2020

Non disponibile.
Preparedness, Confidence, and Best Practices in Preventing, Recognizing, and Managing Mental Health Cases in National Collegiate Athletic Association Institutions
Authors: Young Julia , Neil Elizabeth R. , Granger Kelcey , Walker Stacy E. , Chadburn Jennifer L. , Eberman Lindsey E.
Published: November 2020

Context

Currently, the National Collegiate Athletic Association (NCAA) recommends written policies and procedures that outline steps to support student-athletes facing a mental health challenge and the referral processes for emergency and nonemergency mental health situations.

Objective

To assess the mental health policies and procedures implemented and athletic trainers' perceived confidence in preventing, recognizing, and managing routine and crisis mental health cases across all 3 divisions of NCAA athletics.

Design

Cross-sectional survey design and chart review.

Setting

Online survey.

Patients or Other Participants

Athletic trainers with clinical responsibility at NCAA member institutions (N = 1091, 21.5% response rate).

Main Outcome Measure(s)

Confidence in screening, preventive patient education, and recognizing and referring athletes with routine and emergency mental health conditions (5-point Likert scale: 1 = not at all confident, 2 = hardly confident, 3 = somewhat confident, 4 = fairly confident, 5 = very confident) using a content-validated survey (Cronbach α = 0.904) and mental health policy and procedure chart review.

Results

Respondents indicated they felt fairly confident in screening (40.21%, n = 76 of 189) for risk of any mental health condition and fairly confident in implementing preventive patient education (42.11%, n = 80 of 190). They were fairly confident they could recognize (48.95%, n = 93 of 190) and refer (45.79%, n = 87 of 190) patients with routine mental health conditions. Participants were fairly confident they could recognize (46.84%, n = 89 of 190) but very confident (46.32%, n = 88 of 190) they could refer individuals with mental health emergencies. Policies lacked separate procedures for specific emergency mental health situations such as suicidal or homicidal ideation (36.1%), sexual assault (33.3%), substance abuse (19.4%), and confusional state (13.9%). Policies also lacked a plan for regular engagement of student-athletes in leadership roles (16.7%) and annual training of all student-athletes (16.7%).

Conclusions

Although athletic trainers were generally confident in their ability to address emergency and routine mental health conditions, opportunities exist to improve policies for prevention, screening, and referral. Best-practice guidelines should be used as a guide to develop policies that foster an environment of mental health wellness.
Lateral ankle sprain increases subsequent ankle sprain risk: a systematic review
Authors: Wikstrom Erik A , Cain M Spencer , Chandran Avinash , Song Kyeongtak , Regan Tasha , Migel Kimmery , Kerr Zack Y
Published: November 2020

Objective: To evaluate the evidence surrounding the association between lateral ankle sprain (LAS) history and subsequent LAS risk, as well as sex-differences in the observed associations.

Data Sources: PubMed, CINAHL, and SPORTDiscus were searched through July 2020 for articles reporting LAS injury history and injury incidence during a study period.

Study Selection: Studies were included if they were prospective in nature, reported the number of participants with and without a history of LAS at study initiation, and reported the number of participants from each group that sustained a LAS during the study period.

Data Extraction: Data included study design parameters as well as the number of participants with and without a LAS history, and the number of subsequent LAS that occurred to both groups. Risk ratios (RR) with 95% confidence intervals (CI) compared the risk of LAS within the study period between those with and without a LAS history for each included investigation.

Data Synthesis: Nineteen studies with a total of 6,567 patients were included. Follow-up periods ranged from 14 weeks to 2 years. Quality assessment scores indicate moderate to high quality studies were included. A significantly higher risk of LAS within the study period was observed among those with a history of LAS in 10 out of 15 studies (RR range=1.29–6.06). Similar associations were seen in four out of six studies that included an all-male sample (RR Range=1.38–8.65), and one out of four studies with an all-female sample (RR=4.28).

Conclusion: There is strong evidence to support that a previous LAS increases the risk of a subsequent LAS injury. Males but not females with a history of a LAS appear to be at a higher risk of sustaining a subsequent LAS but further data are needed to draw definitive conclusions based on the limited number of sex specific studies.
Reliability and Validity of a Clinical Assessment Tool for Measuring Scapular Motion in All 3 Anatomical Planes
Authors: Silverson Oliver A. , Lemaster Nicole G. , Hettrich Carolyn M. , Heebner Nicholas R. , Uhl Tim L.
Published: November 2020

Context

A single clinical assessment device that can be used to objectively measure scapular motion in each anatomical plane is not currently available. The development of a novel electric goniometer would allow scapular motion in all 3 anatomical planes to be quantified.

Objective

To investigate the reliability and validity of an electric goniometer for measuring scapular motion in each anatomical plane during upper extremity elevation.

Design

Cross-sectional study.

Setting

Laboratory.

Patients or Other Participants

Sixty participants (29 women, 31 men; age = 30 ± 14 years, height = 1.73 ± 0.10 m, mass = 75.32 ± 16.90 kg) recruited from the general population.

Intervention(s)

An electric goniometer was used to record clinical measurements of scapular position at rest and total arc of motion (excursion) during active upper extremity elevation in 2 testing sessions separated by several days. Measurements were recorded independently by 2 examiners. In 1 session, scapular motion was recorded simultaneously using a 14-camera, 3-dimensional optical motion-capture system.

Main Outcome Measure(s)

Reliability analysis included examination of clinical measurements for scapular position at rest and excursion during each condition. Both the intrarater reliability between testing sessions and the interrater reliability recorded in the same session were assessed using intraclass correlation coefficients (ICCs [2,3]). The criterion validity was examined by comparing the mean excursion values of each condition recorded using the electric goniometer and the 3-dimensional optical motion-capture system. Validity was assessed by evaluating the average difference and root mean square error.

Results

The between-sessions intrarater reliability was moderate to good (ICC [2,3] range = 0.628–0.874). The within-session interrater reliability was moderate to excellent (ICC [2,3] range = 0.545–0.912). The average difference between total excursion values recorded using the electric goniometer and the 3-dimensional optical motion-capture system ranged from −7° to 4°, and the root mean square error ranged from 7° to 10°.

Conclusions

The reliability of scapular measurements was best when a standard operating procedure was used. The electric goniometer provided an accurate measurement of scapular excursions in all 3 anatomical planes during upper extremity elevation.
Clinical Feasibility and Utility of a Dual-Task Tandem Gait Protocol for Pediatric Concussion Management
Authors: Wingerson Mathew J. , Seehusen Corrine N. , Walker Gregory , Wilson Julie C. , Howell David R.
Published: November 2020

Context

Clinical management of sport-related concussion requires the assessment of various factors, including motor performance. The tandem gait test, a measure of postinjury motor performance, has demonstrated clinical utility but is limited by time availability and test uniformity.

Objective

To assess intrasession reliability between tandem gait test trials and determine the number of trials necessary for optimal utility and feasibility in clinical decision-making after concussion.

Design

Cross-sectional study.

Setting

Pediatric sport medicine clinic.

Patients or Other Participants

Adolescent athletes who recently sustained a concussion (n = 44; age = 15.4 ± 1.8 years; 39% females) and were seen for care within 14 days (7.3 ± 3.2 days) of their injury as well as uninjured control participants (n = 73; age = 15.8 ± 1.3 years; 41% females). All individuals completed 3 single-task and 3 dual-task tandem gait trials.

Main Outcome Measure(s)

We collected test completion time and cognitive performance for each trial and calculated Pearson correlation coefficients between trials and intraclass correlation coefficients (ICCs) to determine intrasession reliability. We also compared performance between groups and calculated area under the curve (AUC) values to identify the ability of each trial to distinguish between groups.

Results

Both the concussion and control groups demonstrated high intrasession reliability between tandem gait trials under single- (R ≥ 0.82, ICC ≥ 0.93) and dual- (R ≥ 0.79, ICC ≥ 0.92) task conditions. The greatest group classification values were obtained from the second single-task trial (AUC = 0.89) and first dual-task trial (AUC = 0.83). Test completion time provided excellent between-groups discrimination in single- and dual-task conditions. However, cognitive performance during dual-task trials demonstrated only marginally significant clinical utility (AUC ≤ 0.67).

Conclusions

Tandem gait assessments may only require 2 trials under single-task and 1 trial under dual-task conditions to effectively discriminate between concussion and control groups. This approach may improve the feasibility (ie, time requirement) of the test while maintaining excellent discriminatory ability.