bluuebunny/crossref_metadata_2025 huggingface dataset:
Genome sequencing of Mycobacterium pinnipedii strains: genetic characterization and evidence of superinfection in a South American sea lion (Otaria flavescens)
Authors: Pereira Taiana Silva , Ikuta Cássia Y. , Zimpel Cristina K. , Camargo Naila C. S. , Filho Antônio F. de Souza , Neto José S. Ferreira , Heinemann Marcos B. , Guimarães Ana M. S.
Published: December 2019

Background: Mycobacterium pinnipedii , a member of the Mycobacterium tuberculosis Complex (MTBC), is capable of infecting several host species, including humans. Recently, ancient DNA from this organism was recovered from pre-Columbian mummies of Peru, sparking debate over the origin and frequency of tuberculosis in the Americas prior to European colonization.
Results: We present the first comparative genomic study of this bacterial species, starting from the genome sequencing of two M. pinnipedii isolates (MP1 and MP2) obtained from different organs of a stranded South American sea lion. Our results indicate that MP1 and MP2 differ by 113 SNPs (single nucleotide polymorphisms) and 46 indels, constituting the first report of a mixed-strain infection in a sea lion. SNP annotation analyses indicate that genes of the VapBC family, a toxin-antitoxin system, and genes related to cell wall remodeling are under evolutionary pressure for protein sequence change in these strains. OrthoMCL analysis with seven modern isolates of M. pinnipedii shows that these strains have highly similar proteomes. Gene variations were only marginally associated with hypothetical proteins and PE/PPE (proline-glutamate and proline-proline-glutamate, respectively) gene families. We also detected large deletions in ancient and modern M. pinnipedii strains, including a few occurring only in modern strains, indicating a process of genome reduction occurring over the past one thousand years. Our phylogenomic analyses suggest the existence of two modern clusters of M. pinnipedii associated with geographic location, and possibly host species, and one basal node associated with the ancient M. pinnipedii strains. Previously described MiD3 and MiD4 deletions may have occurred independently, twice, over the evolutionary course of the MTBC.
Conclusion: The presence of superinfection (i.e. mixed-strain infection) in this sea lion suggests that M. pinnipedii is highly endemic in this population. Mycobacterium pinnipedii proteomes of the studied isolates showed a high degree of conservation, despite being under genomic decay when compared to M. tuberculosis . This finding indicates that further genomes need to be sequenced and analyzed to increase the chances of finding variably present genes among strains or that M. pinnipedii genome remodeling occurred prior to bacterial speciation.
Alteration of magmatic monazite in granitoids from the Ryoke belt (SW Japan): Processes and consequences
Authors: Skrzypek Etienne , Sakata Shuhei , Sorger Dominik
Published: December 2019

The alteration of magmatic monazite and its consequences for monazite geochronology are explored in granitoids from the western part of the Ryoke belt (Iwakuni-Yanai area, SW Japan). Biotite-granite samples were collected in two plutons emplaced slightly before the main tectono-metamorphic event: the first one, a massive granite (Shimokuhara) adjoins schistose rocks affected by greenschist facies metamorphism; and the second, a gneissose granite (Namera) adjoins migmatitic gneiss that experienced upper-amphibolite facies conditions. Despite contrasting textures, the granite samples have similar mineral modes and compositions. Monazite in the massive granite is dominated by primary domains with limited secondary recrystallization along cracks and veinlets. It is variably replaced by allanite+apatite±xenotime±Th-U-rich phases. The outermost rims of primary domains yield a weighted average 206Pb/238U date of 102 ± 2 Ma while the Th-U phases show Th-U-Pb dates of 58 ± 5 and 15 to 14 ± 2–3 Ma. Monazite in the gneissose granite preserves sector- or oscillatory-zoned primary domains cross-cut by secondary domains enriched in Ca, Y, U, P, and containing numerous inclusions. The secondary domains preserve concordant 206Pb/238U dates spreading from 102 ± 3 to 91 ± 2 Ma while primary domain analyses are commonly discordant and range from 116 to 101 Ma.

Monazite alteration textures in the two granites chiefly reflect differences in their post-magmatic histories. In the massive granite, monazite replacement occurred via a nearly stoichiometrically balanced reaction reflecting interaction with an aqueous fluid enriched in Ca+Al+Si±F during hydrothermal alteration of the granitic assemblage, likely below 500 °C. In the gneissose granite, a small amount of anatectic melt, probably derived from the neighboring metasedimentary rocks, was responsible for pseudomorphic recrystallization of monazite by dissolution-reprecipitation above 600 °C. Regardless of whether monazite underwent replacement or recrystallization, primary monazite domains preserve the age of magmatic crystallization for both plutons (102 ± 2 and 106 ± 5 Ma). Conversely, the age of monazite alteration is not easily resolved. Monazite replacement in the massive granite might be constrained using the Th-U-rich alteration products; with due caution and despite probable radiogenic Pb loss, the oldest date of 58 ± 5 Ma could be ascribed to chloritization during final exhumation of the granite. The spread in apparently concordant 206Pb/238U dates for secondary domains in the gneissose granite is attributed to incomplete isotopic resetting during dissolution-reprecipitation, and the youngest date of 91 ± 2 Ma is considered as the age of monazite recrystallization during a suprasolidus metamorphic event. These results reveal a diachronous, ca. 10 Ma-long high-temperature (HT) history and an overall duration of about 15 Ma for the metamorphic evolution of the western part of the Ryoke belt.
Influence of artificial shading on seedling production of Tachigali myrmecophila (Ducke) Ducke.
Authors: Sousa Pablo Ruan Ferreira de , Casseb Bruna da Silva , Silva Mizael Cirineu da , Palheta Lenilson Ferreira , Simões Pedro Henrique Oliveira , Lima Clenes Cunha , Azevedo Natália Cristina de Almeida , Silva Luan Felipe Feitosa da , Nogueira Glauco André dos Santos , Neto Cândido Ferreira de Oliveira , Araujo Dênmora Gomes de , Paiva Andressa Pinheiro de , Pires Helaine Cristine Gonsalves , Sousa Luciana Ingrid Souza de , Paula Manoel Tavares de
Published: December 2019

The objective of this work was to evaluate the influence of shade level on the production of T. myrmecophila seedlings. After 30 days of seedling transplantation, the seedlings were submitted to the following treatments: 100% light (full sun), 75% light and 50% light. The statistical design was completely randomized with 5 replicates of 10 seedlings each per treatment. The data were analyzed by repeated measures in time, in 5 measurements, performed every 30 days (150 days of evaluation). The analyzed variables were shoot height and diameter. The environment with 75% luminosity was the one that contributed most to the growth in height of the seedlings, having presented higher mean values over time, in the 5th month (34.94 cm). The most pronounced effect for growth in diameter was verified in the 5th month of evaluation, where the highest average was obtained in the environment with 50% of shading (4.61 mm). The T. myrmecophila seedlings were influenced by the shading levels used. From the results evaluated, treatments with 75% and 50% of solar radiation provided superior growth for dendrometric variables height and diameter, respectively. Therefore, we recommend environments with 75% and 50% of solar radiation for the production of T. Myrmecophila seedlings.
Bowman layer transplantation in eyes with progressive advanced keratoconus
Authors: Oganesyan O. G. , Getadaryan V. R. , Makarov P. V. , Grdikanyan A. A.
Published: December 2019

Purpose:to study the efficiency of Bowman layer transplantation (BLT) in corneal stroma for the treatment of progressive keratoconus (KC).

Material and methods.30 patients (30 eyes) with progressive KC stages III to IV (according to Amsler — Krumeich classification), underwent BLT into a mid-stromal pocket. At the time of surgery, the patients were 14 to 37 (averagely 26.6 ± 6.2 years). Before and after the surgery, the maximum keratometry index (Kmax) and the corneal thinnest point (CTP) values were determined. Also, we evaluated visual acuity before and after surgery in scleral contact lenses, endothelial cells density (ECD) and the depth of graft location. The indication for surgery was the refusal of corneal transplantation, progression of KC, contraindications for ultraviolet crosslinking or implantation of intracorneal ring segments based on the CTP and Kmax values. The follow-up continued 6 to 36 months (averagely, 26.6 ± 6.0 months).

Results.Throughout the observation period, no intra or postoperative complications associated with BLT or deterioration of CTP, Kmax or best corrected visual acuity (BCVA) in scleral lenses were noted.

Conclusions.Kmax, CTP and ECD values remaining stable during the follow-up is the evidence of a stabilizing BLT effect on the KC progression. The absence of BCVA decrease in scleral lenses indicates a functional safety of BLT.
Antiinflammatory therapy of neurotrophic corneal diseases
Authors: Yani E. V. , Orlova E. N. , Golikova V. A.
Published: December 2019

Clinical data on new directions in combined treatment of neurotrophic keratitis, including anti-inflammatory therapy are presented.

Purpose. To compare the effectiveness of bromfenac 0.09 %, nepafenac 0.1 % and indomethacin 0.1 % eye drops in the treatment of neurotrophic keratitis (NK).

Materials and methods. 22 NK patients, aged 34 to 78, were divided into three groups. Group I received bromfenac 0.09 %, group II, nepafenac 0.1 %, and group III, indomethacin 0.1 %. Ophthalmic tests included visometry, biomicroscopy, corneal sensitivity determination, as well as diagnostic tests to determine indicators of tear production (Schirmer test, Norn test, LIPCOF test), and measuring lacrimal meniscus height.

Results. Between visits V2 and V3, patients of group III showed an increase in conjunctival irritation to an average of 2.3 points, while groups I and II revealed the condition of the conjunctiva at 0.9 and 1.1 points, respectively. The lesion area was evaluated in points (max = 20) and averaged on V1 6.8 points in group I, 5.9 points in group II and 7.2 points in group III. Keratopathy in group I which was estimated at 3.8 points before V2, dropped to 1.4 points by V3. In group III it was 1.7 points by V3. In group II, keratopathy showed only 4.1 points by V3. The average Norn test on the day of treatment showed 2.7 seconds in group I, 2.5 seconds in group II, and 3.1 seconds in group III. No significant increase in Schirmer's test results in all groups was recorded.

Conclusion. The use of non-steroidal anti-inflammatory eye drops of various groups — bromfenac 0.09%, nepafenac 0.1 % and indomethacin 0.1 % — gave a positive result in NK therapy. However, bromfenac 0.09% instillations administered once a day produce a higher anti-inflammatory effect then the same quantity of nepafenac 0.1% and indomethacin 0.1 % instillations.
Small choroidal melanoma and pseudomelanomas: methods of differential diagnostics. Part 1
Authors: Myakoshina E. B.
Published: December 2019

Choroidal melanoma is a malignant tumor prone to early metastasis. Its clinical picture is polymorphic, as a result of which it can simulate many diseases of the fundus, which are referred to in the literature as pseudomelanomas. Among these are: choroidal nevus, localized choroidal hemangioma, melanocytomas, choroidal metastatic carcinoma, congenital hypertrophy of retinal pigment epithelium, late stage of age-related macular degeneration, focal retinal choroiditis, organized subretinal hemorrhage, retinal hemangiomas. However, studies comparing the clinical signs of all listed pseudomelanomas and small choroidal melanoma are few. The first part of the review describes the ophthalmoscopic picture of the small choroidal melanoma and pseudomelanomas.
Application of CRISPR/Cas9 Genome Editing System in Cereal Crops
Authors: Hillary V. Edwin , Ceasar S. Antony
Published: December 2019

Recent developments in targeted genome editing accelerated genetic research and opened new potentials to improve the crops for better yields and quality. Genome editing techniques like Zinc Finger Nucleases (ZFN) and Transcription Activator-Like Effector Nucleases (TALENs) have been accustomed to target any gene of interest. However, these systems have some drawbacks as they are very expensive and time consuming with labor-intensive protein construction protocol. A new era of genome editing technology has a user-friendly tool which is termed as Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-CRISPR associated protein9 (Cas9), is an RNA based genome editing system involving a simple and cost-effective design of constructs. CRISPR/Cas9 system has been successfully applied in diverse crops for various genome editing approaches. In this review, we highlight the application of the CRISPR/Cas9 system in cereal crops including rice, wheat, maize, and sorghum to improve these crops for better yield and quality. Since cereal crops supply a major source of food to world populations, their improvement using recent genome editing tools like CRISPR/Cas9 is timely and crucial. The genome editing of cereal crops using the CRISPR/Cas9 system would help to overcome the adverse effects of agriculture and may aid in conserving food security in developing countries.
Otitis External Infections Among Jordanian Patients with Emphasis on Pathogenic Characteristics of Pseudomonas aeruginosa Isolates
Authors: ALjaafreha Lubna Y. , Tawalbeh Mohmmed , Shehabi Asem A.
Published: December 2019

Introduction:

Otitis external infection is an inflammation of the ear canal frequently caused by Pseudomonas aeruginosa, followed by Staphylococcus epidermis and Staphylococcus auerus.

Objective:

This study investigated the spectrum of bacterial and fungal agents that cause otitis external infection in Jordanian patients with an emphasis on important antimicrobial resistance genes and putative virulence factors of P. aeruginosa isolates using molecular PCR methods.

Methods:

A total of 128 ear swab samples were obtained from outpatients with otitis external infection of Ear-Nose-Throat Clinic (ENT) from the Jordan University Hospital (JUH). All samples were cultured for bacteria and fungi and their growth was identified by macroscopic and microscopic examination as well as recommended biochemical tests.

Results:

Positive growth of bacteria and fungi were found in 105/128 (82%) of the examined cases. A total of 28 (22%) of the recovered organisms from ear samples were P. aeruginosa. A total of 11/28 (39%) of P. aeruginosa isolates were Multidrug-Resistant (MDR) which are resistant to three or more antibiotic classes. Both blaIMP-15 and VIM genes were not detected, while KPC genes were found in 57% among all isolates. The rates of the potential virulence genes found among 28 P. aeruginosa isolates were as follows: lasB, algD, toxA, exoU PilB and exoS at 100%, 100%, 82%, 72%, 54% and 25%, respectively. All isolates produced beta hemolysis on both human and sheep blood agar and showed either the pigment pyoverdin (57.1%) or pyocyanin (42.8%).

Conclusion:

Accurate identification of the causative agent of otitis external infection and its susceptibility to antibiotics especially P.aeruginosa is highly important for successful treatment. No significant relationship has been found between MDR
P. aeruginosa and the presence of virulence genes.
Augmenting Safety Planning With Text Messaging Support for Adolescents at Elevated Suicide Risk: Development and Acceptability Study (Preprint)
Authors: Czyz Ewa K , Arango Alejandra , Healy Nathaniel , King Cheryl A , Walton Maureen
Published: December 2019

BACKGROUND

Suicide is the second leading cause of death among adolescents. A critical need exists for developing promising interventions for adolescents after psychiatric hospitalization who are at a high risk of experiencing repeated suicidal behaviors and related crises. The high-risk period following psychiatric hospitalization calls for cost-effective and scalable continuity of care approaches to support adolescents’ transition from inpatient care. Text messages have been used to improve a wide range of behavioral and health outcomes and may hold promise as an accessible continuity of care strategy for youth at risk of suicide.

OBJECTIVE

In this study of 40 adolescents at elevated suicide risk, we report on the iterative development and acceptability of a text-based intervention designed to encourage adaptive coping and safety plan adherence in the high-risk period following psychiatric hospitalization.

METHODS

Adolescents (aged 13-17 years) who were hospitalized because of last-month suicide attempts or last-week suicidal ideation took part in either study phase 1 (n=25; 19/25, 76% female), wherein message content was developed and revised on the basis of feedback obtained during hospitalization, or study phase 2 (n=15; 11/15, 73% female), wherein text messages informed by phase 1 were further tested and refined based on feedback obtained daily over the course of a month after discharge (n=256 observations) and during an end-of-study phone interview.

RESULTS

Quantitative and qualitative feedback across the 2 study phases pointed to the acceptability of text-based support. Messages were seen as having the potential to be helpful with the transition after hospitalization, with adolescents indicating that texts may serve as reminders to use coping strategies, contribute to improvement in mood, and provide them with a sense of encouragement and hope. At the same time, some adolescents expressed concerns that messages may be insufficient for all teens or circumstances. In phase 2, the passage of time did not influence adolescents’ perception of messages in the month after discharge (P=.74); however, there were notable daily level associations between the perception of messages and adolescents’ affect. Specifically, higher within-person (relative to adolescents’ own average) anger was negatively related to liking text messages (P=.005), whereas within-person positive affect was associated with the perception of messages as more helpful (P=.04).

CONCLUSIONS

Text-based support appears to be an acceptable continuity of care strategy to support adolescents’ transition after hospitalization. The implications of study findings are discussed. Future work is needed to evaluate the impact of text-based interventions on suicide-related outcomes.
Detecting and Filtering Immune-Related Adverse Events Signal Based on Text Mining and Observational Health Data Sciences and Informatics Common Data Model: Framework Development Study (Preprint)
Authors: Yu Yue , Ruddy Kathryn , Mansfield Aaron , Zong Nansu , Wen Andrew , Tsuji Shintaro , Huang Ming , Liu Hongfang , Shah Nilay , Jiang Guoqian
Published: December 2019

BACKGROUND

Immune checkpoint inhibitors are associated with unique immune-related adverse events (irAEs). As most of the immune checkpoint inhibitors are new to the market, it is important to conduct studies using real-world data sources to investigate their safety profiles.

OBJECTIVE

The aim of the study was to develop a framework for signal detection and filtration of novel irAEs for 6 Food and Drug Administration–approved immune checkpoint inhibitors.

METHODS

In our framework, we first used the Food and Drug Administration’s Adverse Event Reporting System (FAERS) standardized in an Observational Health Data Sciences and Informatics (OHDSI) common data model (CDM) to collect immune checkpoint inhibitor-related event data and conducted irAE signal detection. OHDSI CDM is a standard-driven data model that focuses on transforming different databases into a common format and standardizing medical terms to a common representation. We then filtered those already known irAEs from drug labels and literature by using a customized text-mining pipeline based on clinical text analysis and knowledge extraction system with Medical Dictionary for Regulatory Activities (MedDRA) as a dictionary. Finally, we classified the irAE detection results into three different categories to discover potentially new irAE signals.

RESULTS

By our text-mining pipeline, 490 irAE terms were identified from drug labels, and 918 terms were identified from the literature. In addition, of the 94 positive signals detected using CDM-based FAERS, 53 signals (56%) were labeled signals, 10 (11%) were unlabeled published signals, and 31 (33%) were potentially new signals.

CONCLUSIONS

We demonstrated that our approach is effective for irAE signal detection and filtration. Moreover, our CDM-based framework could facilitate adverse drug events detection and filtration toward the goal of next-generation pharmacovigilance that seamlessly integrates electronic health record data for improved signal detection.
INCREMENTAL TAX CREDIT FOR R&D (LEGISLATIVE PROPOSALS)
Authors: Diumina Veronika E.
Published: December 2019

In conditions of limited resources, the government is looking for the most effective way of supporting and innovative development of priority sectors of the economy. Despite the fact that the question of the correlation between direct and indirect methods of stimulating investment and innovation activity remains open, more and more economically developed countries make a choice in favor of tax incentives and preferences. The need of finding the effective mechanisms of stimulating R&D in order to develop knowledge-intensive industries, creation of favorable conditions for innovation activity in the country - all of these confirm the importance of additional restructuring of the taxation system of the innovation sector of the economy. The most common form of tax incentives for innovation activity is tax credit. Based on the analysis of a wide range of foreign studies on the effectiveness of applying a tax credit for stimulating innovation activity, the article discusses and systematizes the positive and negative aspects of applying incremental and volume tax credits for R&D. In the study were used the method of comparative analysis to confront the experience of using different types of tax credit in different countries, the methods of cause-effect and system analysis to identify the main positive and negative aspects of applying volume and incremental tax credits. Based on dialectical method of knowledge, the directions of improving the mechanism of incremental tax credit were formulated. As the result of the analysis the assessment of applying the incremental tax credit for R&D in the existing tax system of Russian Federation and the recommendations for its transformation for increasing the effectiveness are given.
PROBLEMS OF DEMOCRACY: A NEW VIEW. BOOK REVIEW: DEMOCRACY: EXPERIENCE OF CRITICAL ANALYSIS. BY A.D. KERIMOV. MOSCOW. NORMA, 2019
Authors: Ekimov Anisim I.
Published: December 2019

The peer-reviewed book is the first and only domestic publication in which the critique of democracy as a sociocultural and political-legal phenomenon is amply and concentratedly presented. The author confidently proves that democracy is not the power of the people or the power of the majority, but only a certain technology, a mechanism for acquiring and exercising state power by a minority with the help of the majority, but not always in the interests of the majority.
O baú do Laurimar: documentos biográficos e narrativas da cultura em Santarém/PA
Authors: Carvalho Luciana Gonçalves de , Santos Filho Osinaldo Raphael Lima dos , Souza dos Santos Elber Norton
Published: December 2019

Relatos biográficos de Laurimar dos Santos Leal, contados com o auxílio de documentos íntimos arquivados em um velho baú de madeira abrigado no chamado “museu da cidade”, são o fio condutor deste artigo que investiga a relação desse indivíduo com o campo institucional da cultura em Santarém, no Pará. Laurimar é artista plástico, compositor, carnavalesco, restaurador e colecionador, e, foi, por muitos anos, diretor do Centro Cultural João Fona – principal instituição museológica de Santarém. Em inúmeras sessões de entrevistas que resultam no registro de sua história de vida, constatam-se interseções frequentes entre os domínios público e privado em sua trajetória, revelando que ela própria está intimamente atrelada à institucionalização de espaços e práticas estruturantes do campo da cultura no município.
Multi-component reconstructive heart surgery as an alternative to transplantation in a patient with combined cardiac pathology and critically low left ventricular contractility
Authors: Sokolov V. V. , Redkoborodyy A. V. , Rubtsov N. V. , Khutsishvili L. G. , Ostroumov E. N. , Migunova E. V. , Bikbova N. M.
Published: December 2019

Introduction. Cardiovascular diseases rank leading in the world. The decompensation of chronic heart failure is the direct cause of death in most patients. The choice of a definitive treatment tactics is the key factor in these patients.

Clinical case. A patient who had experienced myocardial Q-infarction with an ST segment elevation of anterior septal location complicated by the left ventricle anterior wall aneurysm and a decreased myocardial contractility was hospitalized with subcompensated chronic heart failure. Previously, and initially with that hospitalization, the patient was considered a candidate for heart transplantation. After the examination, a decision was made on the possibility of a multi-component reconstructive heart surgery, which was performed with a good clinical effect.

Conclusion. The presented clinical case has confirmed the possibility of correcting the combined pathology in a patient with low myocardial contractility obtaining good immediate and long-term (1.5 years after surgery) results.
A didatização de gêneros multimodais: práticas de leitura das histórias em quadrinhos em livros didáticos de língua portuguesa
Authors: Cani Josiane Brunetti
Published: December 2019

O objetivo deste estudo é identificar a abordagem do gênero história em quadrinhos nos livros didáticos de língua portuguesa quanto a aspectos gramaticais, críticos, ilustrativos e, principalmente, semióticos. Tal proposta encontra relevância acadêmica e social na multimodalidade, considerando uma sociedade que requer cada vez mais uma competência comunicativa multissemiótica. Os pressupostos aplicados à análise emergem da teoria cognitiva de aprendizagem multimodal, desenvolvida por Richard Mayer, e do discurso da história em quadrinhos, abordado por Sônia Luyten. Por meio de pesquisa documental e qualitativa, este estudo tem como corpus livros do nono ano do ensino fundamental, inscritos no Programa Nacional do Livro Didático do triênio 2014-2016. Os resultados apontam que, embora a inclusão desse gênero textual nos livros didáticos se faça de maneira significativa, a exploração dos recursos multimodais ainda é incipiente, porquanto as histórias em quadrinhos são utilizadas significativamente como pretexto para análise gramatical.
As avaliações certificativas em língua francesa: um diferencial no currículo do profissional de secretariado executivo brasileiro?
Authors: Martins Santos Emili Barcellos , Souza Eduardo César Pereira
Published: December 2019

No âmbito social, os estudos realizados e os diplomas obtidos são fatores considerados decisivos para a determinação de classes sociais. Neste contexto, as avaliações certificativas em língua estrangeira assumem um papel significativo, sobretudo, para aqueles indivíduos que veem na obtenção de certificações um elemento de diferenciação em seus currículos. Este estudo tem como objetivo analisar e discutir as representações sociais de estudantes de graduação e de profissionais da área de secretariado executivo acerca das avaliações certificativas em língua francesa. Foram analisados os discursos de dezoito estudantes e de oito profissionais brasileiros de secretariado, obtidos por meio da aplicação de um questionário. A discussão dos resultados deste trabalho demonstra que, embora estivessem em momentos profissionais distintos, tanto os estudantes quanto os profissionais compartilhavam representações semelhantes em relação ao papel desempenhado pela avaliação certificativa no contexto secretarial, que são apresentadas e discutidas neste artigo.
Instapoesia: Literatura em meio digital no ensino e aprendizagem de inglês
Authors: Amarante Maria de Fatima Silva , Guimarães de Lima Paloma , Azzari Eliane Fernandes
Published: December 2019

Neste artigo, abordamos o papel das literaturas em língua inglesa no ensino de inglês na escola regular e, adotando viés sociocultural, buscamos deslocar a educação linguística da visão tradicionalmente centralizada em aspectos estruturais. Para tanto, por meio de um estudo propositivo, sugerimos o trabalho com a instapoesia, um gênero multimodal, desenvolvido no âmbito da ciberliteratura. Apropriamo-nos dessas narrativas literárias, que caracterizam práticas sociais contextualizadas no âmbito digital, para realocá-las em sala de aula, de modo a ampliar discussões atuais e situadas acerca de língua(gens) e de culturas de língua inglesa. Acatando a perspectiva dos letramentos críticos, nosso estudo favorece uma abordagem de ensino e aprendizagem pluralista. Assim, com o apoio da etnografia digital para a busca de textos no ciberespaço, selecionamos e capturamos telas em que se divulgam produções da poeta indiana Rupi Kaur, publicadas entre agosto e setembro de 2018. Adicionalmente, nossa proposta sugere que os textos escolhidos também nos permitem discutir o caráter narrativo da construção da diferença, propiciando aos estudantes de inglês a reflexão sobre representações femininas e seus espaços sociais.
Tempo de mudança: a partida como primeiro estágio da Jornada Mitológica de Mulheres Olímpicas Brasileiras
Authors: Amato Júlia Frias , Rubio Katia
Published: December 2019

No Brasil, muitas crianças e jovens têm a oportunidade de conhecer diferentes modalidades esportivas. Por vezes, esse contato desperta um encanto pelo esporte, sendo a ele dada uma importância e um significado tão grandes que fazem com que eles o prefiram às atividades comuns para outras pessoas da mesma idade, como brincadeiras, convívio familiar ou escolar. Em busca de melhores condições de treinamento e desenvolvimento, esses futuros atletas, muitas vezes, têm que se distanciar de seu núcleo familiar ainda de forma precoce. Este trabalho buscou investigar como as mulheres olímpicas brasileiras, medalhistas de modalidades coletivas, reconhecem o momento que marcou o início de sua especialização esportiva, exclusivamente aquelas em cuja história consta a marca do distanciamento familiar e da saída de casa. A metodologia do trabalho se ancora nas narrativas biográficas, considerada uma modalidade de história oral. Depois de alcançarem a condição de atleta olímpica, é possível pensar que o chamado para a prática esportiva e o distanciamento precoce de seu núcleo familiar foram os primeiros passos para o que seria o início de sua jornada enquanto atleta.
Reflexões sobre a clínica ampliada nos Centros de Referência da Assistência Social (CRAS)
Authors: Silva Rafael Bianchi , Bonatti Graziela Lastoria
Published: December 2019

O presente trabalho propõe uma reflexão sobre as possíveis relações da clínica ampliada com as práticas da psicologia no Sistema Único de Assistência Social dentro dos Centros de Referência de Assistência Social (CRAS) no trabalho com famílias do Plano Nacional de Atendimento Integral à Família (PAIF). Para isso foi apresentada a criação do SUAS e levantado o histórico sobre a clínica ampliada no Brasil para assim analisar, a partir dos documentos da referida política, as possíveis articulações da atuação do psicólogo no CRAS com a noção de clínica ampliada, a fim de ressignificar as suas atividades no SUAS.
From Integrity to the New Split and Rivalry? (World-System and World Order in Changing Realities)
Authors: Ryabov A. V.
Published: December 2019

The collapse of the Soviet Union and socialist commonwealth contributed to the reconstruction of integrity of the World-System. These changes became a major global transformation of the second half of the XX century. Then there was an opinion that over time the model of liberal capitalism would be established in all countries. However the restoration of the integrity of the global world did not lead to shaping of its homogeneity. New contradictions emerged both between developed and developing countries and within the core countries of the World-System. All of this undermined stability of the system and contributed to the gradual distraction of the unipolar world order. Russia initially tried to be integrated into the new world reality and become the main partner of the USA as a center of the World-System. However the plans of the United States and its allies did not provide that Russia would retain its role as an important and independent actor in world politics. As a result, Russia’s integration into the West did not take place. Nevertheless having made the transition to an independent policy not subordinated to the USA and its allies Russia could not claim to create alternative global social project as the Soviet Union had. To do this Russia had neither resources nor attractive idea for the rest of the world. As China began to turn into economic superpower it seemed that Beijing was not going to offer the world its own social project alternative to liberal capitalism but it claimed only to take place in existing global system corresponding to its economic impact. Situation was changed after the USA in the middle of the 10-th felt in China a serious rival and moved to the policy of deterrence of it. China began to work out its own model of the world order. Now in comparison with the past many experts suppose that Chinese model of the social and political order may be used by other developing countries. Will this lead to emergence of the new global project alternative to the Western liberal capitalism and to distraction of integrity of the World-System? Will there be a new global transformation as a result of current processes? This article is devoted to the analysis of probable prospects of these tendencies of the world development.
PENINGKATAN HASIL BELAJAR IPS (MASALAH SOSIAL) DENGAN PENERAPAN METODE DISKUSI DENGAN TINDAKAN REFLEKTIF
Authors: Nurhayati Nurhayati
Published: December 2019

Penelitian ini adalah penelitian tindakan kelas yang bertujuan untuk peningkatan hasil belajar ilmu pengetahuan sosial pada siswa kelas IV SDN 012 Bukit Raya Kec. Tenayan Raya Pekanbaru  melalui penerapan metode diskusi dengan tindakan reflektif. Subjek penelitian  adalah  guru dan siswa kelas IV SD Negeri 012 Bukit Raya Kec. Tenayan Raya Pekanbaru. Metode diskusi dengan tindakan reflektif adalah paduan metode diskusi dengan pembelajaran reflektif, adapun metode diskusi adalah suatu cara atau proses penyajian bahan pelajaran dimana guru memberikan kesempatan kepada para siswa (kelompok-kelompok siswa) untuk mengadakan perbincangan ilmiah guna mengumpulkan pendapat, membuat kesimpulan  atau penyusun berbagai alternatif pemecahan atas suatu masalah, sedangkan pembelajaran reflektif merupakan bagian dari lima system pembelajaran primer yaitu emosional, sosial, kognitif, fisik dan reflektif. Reflektif adalah respon terhadap kejadian, aktivitas atau pengetahuan yang baru diterima atau cara berfikir tentang apa yang baru dipelajari, berfikir kebelakang tentang apa yang sudah dipelajari dan dilakukan masa lalu.Berdasarkan hasil analisis data dan pembahasan, hasil belajar siswa pada siklus I menunjukkan bahwa dari 39 siswa sebanyak 23 orang siswa (58%) mencapai KKM dan pada siklus II meningkat menjadi 38 orang siswa (97%), sehingga dapat disimpulkan  bahwa pembelajaran  dengan penerapan metode diskusi dengan tindakan reflektif mampu meningkatkan hasil belajar siswa pada mata pelajaran IPS pokok pembahasan masalah sosial.
Implementasi Kegiatan Ektstrakurikuler PAI (Ikhrohist) untuk Pembinaan Akhlak
Authors: Sudiran Sudiran
Published: December 2019

This researh is about the implementation of extracurricular activities (ikrohist) for guide students’ attitude in SMK Penerbangan Techno Terapan Makassar. This research method is a qualitative research using of normative theology, pedagogic, physicologic, and sociologic. The research instruments used interview, observation, and documentation. Informant consisted of principal, refresentative of the school, and teachers. Data collection was done by observation, interview and documentation techniques.  Data analysis by means of data reduction, data presentation, conclusion and data verification.  The result of this research, there are: 1) Students’ attitudes in SMK Penerbangan Techno Terapan Makassar, after joining the extracurricular activities showed good attitudes. 2) Students’ Attitudes in SMK Penerbangan Techno Terapan Makassar based on the observation and interview that give awardness, discipline, extracurricular activities (Ikrohist) in SMK Penerbangan Techno Terapan Makassar consisted of three parts, they are dayly/weekly activities, monthly activities and annual activities.
Interference in English Language Learning Among Indonesia Students
Authors: . Fauzia
Published: December 2019

English has been considered to be first foreign and second language in Indonesia It
functions to help the development of the state and nation, to build relation with other
nations, and to run foreign policy including as a language used for wider communication
in international forum. There are a lot of problems found in the English learning language
learning. One of kind is interference. Interference means the influence that the learner’s
L1 exerts over the acquisition of an L2. There are several causes of interference in
language learning, which are: 1) bilingualism, 2) the similarity between the shape of L1
and L2, and 3) the ease for second language learners
Effect of Sodium Butyrate on Intestinal Health of Poultry – A Review
Authors: Elnesr Shaaban S. , Alagawany Mahmoud , Elwan Hamada A.M. , Fathi Mohamed A. , Farag Mayada R.
Published: December 2019

Health of the intestine is one of the main reasons that affects the bird’s performance, and thus the economic yield in the poultry sector. Various studies have examined how to improve the intestinal health using dietary supplements, including organic acids such as sodium butyrate (SB). The efficacy of the dietary supplementation in poultry is often assessed using an important parameter such as intestinal integrity, which is often assessed as a measure of high villus height and the ratio of villus height to crypt depth, or count of goblet cell numbers. In broilers, the villus length and width were increased by the addition of dietary SB. Since, at day 21 and 42, the villus length was increased by 55 and 27%, and 39 and 18% for birds fed 0.5 and 1 g/kg, respectively, compared with the control diet. Furthermore, SB plays an important role in development of poultry intestinal epithelium. It can be employed by the intestinal epithelial cells as an energy source to stimulate their differentiation and proliferation, and to improve intestinal barrier function. SB is effective against acid intolerant species such as Salmonella, Clostridium perfringens and E. coli. In addition, use of butyric acid at 0.6% reduced the pH of gastrointestinal segments. For this, SB could be a potential alternative in maintaining the health of gastrointestinal tract and improving the productive performance of poultry. This review refers to the expanding horizons in the research on SB supplementation in poultry health and nutrition.
Healthcare Services Use Among Dental Patients
Authors: Roxana Oancea , Ruxandra Sfeatcu , Maria Gheorghiu Irina , Mitran Mihai , Mitran Loredana , Alexandru-Andrei Iliescu , Perlea Paula
Published: December 2019

Regular medical attendance proved to have a positive impact on health, therefore the aim of the study is to detect the reasons and frequency for health care use among a group of 110 urban dental patients aged between 33 and 75 years, 50% males. The subjects completed an anonymous questionnaire with items related to their medical visits patterns: reason (treatment/control and emergency) and frequency of healthcare services use; self-assessed oral and general health and socio-demographic data. Most of the patients were adults (81.8%) and with more than 12 years of study (50%). In terms of reason for attending the dental office, 72% visited the dentist for emergency reasons, mainly men, elderly, patients with low level of education, and those who self-rated their oral health as satisfying or poor. Regarding medical visits, 54% from all patients attended healthcare for emergency reasons, regardless age, gender, education level and self-perceived general health. The results showed that worse healthcare services use is associated with low education level and gender, especially men visited the dentist when there is pain only. There is need to increase the number of individuals who use regular health care, for prevention and early detection of diseases.
Preliminary Comparative Study on Patients with Mycoses -A Comparison Between Candida and Other Fungal Infections
Authors: Olimpia-Nicoleta Moroianu , Nelu Doru-Popescu , Cristian Petcu Lucian , Gurgas Leonard , Natalia Roșoiu
Published: December 2019

The study aims at highlighting the differences in the main statistical parameters between two groups of patients diagnosed with mycosis, while monitoring the frequency of association with various other conditions.
Agile Project Management Tools: A Brief Comprative View
Authors: Özkan Deniz , Mishra Alok
Published: December 2019

Agile methodologies are becoming popular in software development. Managers are required to understand project’s progress and product quality without development documents. During Agile practices of the teams and organizations, Agile project management tools are frequently used. The use of such tools leads to achieving speed and efficiency, affects the quality of the software. The quality of final product is mostly related with to project management. Accordingly, the paper provides brief comparative perspective about the popular project management tools for agile projects. 16 popular Agile project management tools have been presented helping agile developers to plan and manage their tasks in an efficient manner. Taiga, Axosoft, Agielan, Planbox are more appropriate for start-up projects. The most twitted and most appreciated tools are reported as Jira, Trello, and VersionOne. SpiraTeam by Inflectra and Pivotal Tracker are other pricing and popular agile tools, providing flexibility to Agile developers and increase collaboration among team members.
Particle Swarm Optimization and Tabu Search Hybrid Algorithm for Flexible Job Shop Scheduling Problem – Analysis of Test Results
Authors: Toshev Asen
Published: December 2019

The paper presents a hybrid metaheuristic algorithm, including a Particle Swarm Optimization (PSO) procedure and elements of Tabu Search (TS) metaheuristic. The novel algorithm is designed to solve Flexible Job Shop Scheduling Problems (FJSSP). Twelve benchmark test examples from different reference sources are experimentaly tested to demonstrate the performance of the algorithm. The obtained mean error for the deviation from optimality is 0.044%. The obtained test results are compared to the results in the reference sources and to the results by a genetic algorithm. The comparison illustrates the good performance of the proposed algorithm. Investigations on the base of test examples with a larger dimension will be carried out with the aim of further improvement of the algorithm and the quality of the test results.
Relationship Between Milk Urea Level and Milk Parameters in The Saanen Dairy Goat
Authors: Čobanović Ksenija , Krstović Saša , Štrbac Ljuba , Šaran Momčilo , Kasalica Anka , Popović Milka
Published: December 2019

The aim of this study was to determine the urea level in Saanen goat milk and examine the relationship between milk urea (MU) level and daily milk yield (DMY), milk fat, protein, lactose and solids non-fat (SNF) percentage in dairy goats. The observation was made on 1492 samples of milk control of Saanen goats in the period from March to November 2019. The samples were categorized into four groups based on MU level: I Group 10–20 mg/dl, II group 20.01–30.00 mg/dl, III group 30.01–40.00 mg/dl, IV group >40.01mg/dl. Analyses of raw milk samples were carried out on the FOSS instruments MilcoScan in Laboratory for Milk Quality Control, at the Faculty of Agriculture, Department of Animal Science. Descriptive statistic was done using program Statistica 13.5. The goats on the observed farm were reared in a closed system with balanced diet throughout the whole year. The study showed statistically highly significant differences (P<0.01) among MU groups for all milk parameters. The MU concentration was positively correlated (P<0.01) with fat (%), protein (%), lactose (%) and SNF (%), while it was negatively correlated only with DMY (kg).
Jiří Menzel’s treatment of sacrifice
Authors: Brennan Daniel
Published: December 2019

The paper explores the philosophical treatment of sacrifice in four of Jiří Menzel’s films of the 1960’s, Closely observed trains (Ostře sledované vlaky), Capricious summer (Rozmarné léto), Mr Balthazar’s death (Smrt pana Baltazara), his short film contribution to the anthology film of the New Wave, Pearls of the deep (Perličky na dně), and Larks on a string (Skřivánci na niti). The paper argues that Menzel problematizes romanticized versions of messianic sacrifice as they all too easily disregard the moral significance of mundane relations. By analysing the treatment of sacrifice in each of these films, the paper makes a case for the significance of Menzel’s treatment of sacrifice for current philosophical debates.
Kafka’s animals between mimicry and assimilation
Authors: Di Noi Barbara
Published: December 2019

In Kafka’s literary world, several animals emerge; they belong to an odd and enigmatic fauna, on the edge between violence and artistry but also between stillness and music; according to the writer, scripture represents both the fault and the punishment waiting for the solitary artist. Animals, especially depicted as hordes of small mice or other rodents, also hint to the heterogeneous structure of the Self, who doesn’t manage to keep under control all the divisions in his ambiguous dentity. Through opposition between the point of view of the subject, who considers his own isolation as indispensable to carry on writing, and the multitude of escaping small animals, Kafka also expresses and experiences his own impossibility of “description” (Beschreibung). In the meantime, Kafka’s animals embody the creatural and unconscious sources of imagination the writer draws from that constantly escape his own control and willingness, pushing forwards into an unknown and inhospitable region, towards the wasteland, the eternal winter that can be identified with scripture. In writing, a deep metamorphosis of the Self takes place. Kafka shares this belief with one of the writers he most admired and considered his master, Gustave Flaubert, who firmly thought that, while writing, one loses his previous identity, becoming someone else, even assuming the appearence of the “otherness”. We can state that Kafka’s imagery of animals takes to the extreme the paradox and ambiguity the idea of writing relies on, also reproducing, especially, in his hybrid creatures, the feeling of uncertainty and lack of safety of the assimilated Jewish artist.
Wolf Hall and moral personhood
Authors: Hämäläinen Nora
Published: December 2019

Can a good man do evil things? This paper offers a moral philosophical reading of Hilary Mantel’s novels Wolf Hall and Bring up the bodies, focusing on Mantel’s fictional portrayal of Thomas Cromwell as a good person, in spite of his growing involvement in the dirty work of Henry VIII. The narrative resists interpretations of Cromwell as someone corrupted by power. It also thwarts attempts to read his deeds as results of a deficient capacity for sympathetic imagination, which has been a focalized moral flaw in contemporary moral philosophical discussions of literature. By thus resisting moralized readings of his character, the novels invite intensified attention to the complex dynamics of character and circumstance.