bluuebunny/crossref_metadata_2025 huggingface dataset:
Surgical efficacy and quality of wide resection of the pelvic peritoneum in patients with epithelial ovarian cancer
Authors: Nishimura Akiho , Motohara Takeshi , Morinaga Jun , Iwagoi Yutaka , Yamamoto Mayuko , Yamaguchi Munekage , Miyahara Yo , Tashiro Hironori , Katabuchi Hidetaka
Published: October 2022

Purpose
The aim of study was to evaluate the impact of adding an extensive pelvic peritoneal stripping procedure, termed “wide resection of the pelvic peritoneum,” (WRPP) to standard surgery for epithelial ovarian cancer on survival effectiveness and to investigate the role of ovarian cancer stem cells (CSCs) in the pelvic peritoneum.
Methods
A total of 166 patients with ovarian cancer undergoing surgical treatment at Kumamoto University Hospital between 2002 and 2018 were retrospectively analyzed. Eligible patients were divided into three groups based on the surgical approach: standard surgery (SS) group (n = 36), WRPP group (standard surgery plus WRPP, n = 100), and rectosigmoidectomy (RS) group (standard surgery plus RS, n = 30). Survival outcomes were compared between the three groups. CD44 variant 6 (CD44v6) and EpCAM expression, as markers of ovarian CSCs, in peritoneal disseminated tumors were evaluated using immunofluorescence staining.
Results
With respect to patients with stage III–IV ovarian cancer, there were significant differences in overall and progression-free survival between the WRPP and SS groups, as revealed by univariate (hazard ratio [HR], 0.35; 95% confidence interval [CI], 0.17–0.69; P = 0.003 and HR, 0.54; 95% CI, 0.31–0.95; P = 0.032, respectively) and multivariate Cox proportional hazards model (HR, 0.35; 95% CI, 0.17–0.70; P = 0.003 and HR, 0.54; 95% CI, 0.31–0.95; P = 0.032, respectively). Further, no significant differences were observed in survival outcomes between the RS group and the SS or WRPP group. Regarding the safety of WRPP, no significant differences in major intraoperative and postoperative complications were found between the three groups. Immunofluorescence analysis revealed a high percentage of CD44v6/EpCAM double-positive ovarian cancer cells in peritoneal disseminated tumors.
Conclusion
The present study demonstrates that WRPP significantly contributes to improved survival in patients with stage III–IV advanced ovarian cancer. WRPP could result in eradicating ovarian CSCs and disrupting the CSC niche microenvironment in the pelvic peritoneum.
Family Functioning and Intraindividual Reaction Time Variability Interactively Predict Children’s Externalizing Problems
Authors: Peng Yuan , Wang Xiaoxiao , Hao Yanli
Published: October 2022

Intraindividual reaction time variability (IIV), which serves as an index of attentional control, was related to externalizing problems. However, it remains unknown whether children’s IIV interacts with family functioning, including family adaptability and cohesion, to predict their externalizing problems. The present study examined this concern. Participants included 168 (M = 7.35 years, SD = .48; 48% boys) and 155 (M = 8.32 years, SD = .45; 49% boys) children at the first (T1) and second (after one year, T2) measurements, respectively. At T1, a flanker task was used to assess children’s IIV. Mothers reported the Chinese version of the Family Adaptability and Cohesion Scales and the Chinese version of the Child Behavior Checklist. At T2, mothers reported children’s externalizing problems again. Results indicated that family functioning negatively and IIV positively correlated with children’s externalizing problems. Furthermore, family functioning interacted with children’s IIV to predict their externalizing problems concurrently and longitudinally. Specifically, low family functioning combined with greater IIV predicted prospective externalizing problems. Findings suggested that better attentional control (indexed by low IIV) may buffer the negative effect of poor family functioning.
Optimal Coordinated Energy Management Strategy for DC Nanogrid with Photo voltaic and Hybrid Energy Storage System
Authors: Gugulothu Ramesh , Nagu Bhookya , Pullaguram Deepak
Published: October 2022

Energy storage devices and renewable resources especially rooftop photovoltaic (PV) are vital in operation of nanogrids. In this study, energy management strategy (EMS) for battery energy storage system(BESS), PV, super-capacitor (SC) is presented. The proposed control strategy is designed to optimize BESS flow rate, discharge and charge cycles energy system using Meta-heuristic Jaya algorithm by properly coordinating SC and PV. SC was employed in HESS to fulfill the transient energy mismatches and reduce the transitory high charge/discharge impact on BESS using EMS. The proposed controller also has the benefit of keeping the battery’s SoC within limitations for a long period. In order to extend the life of BESS, the EMS is aimed at minimizing deep charging and discharging. PV generation is reduced, particularly under light load (no-load) situations and when battery SoC ≥ SoCmax. Similarly, SC charging and select able load shedding are employed when SoC ≤ SoCmin to avoid deep discharge. This controller method is validated in both simulation environment and hardware-prototype under different perturbation and operating conditions.
The Prognosis of Thoracolumbar Spine Injury in Cameroon
Authors: Motah Mathieu , Shu Paul Chinonso , Massi Daniel Gams , Ngunyi Yannick Lechedem , Budzi Ngenge Michael , Tanyi Tanyi John , Mefire Alain Chichom
Published: October 2022

Background
Thoracolumbar spine injury (TLSI) secondary to trauma usually occurs abruptly and leaves demeaning consequences, especially in our setting where the prognosis from several studies is poor. A look at the determinants of prognosis at the Douala General Hospital (DGH) would contribute data that could help in improving this prognosis.
Method
This was a hospital-based five-year retrospective study. The study population was patients treated for TLSI in the Douala General Hospital from January 2014 to December 2018. Patients’ medical records were used to retrieve data. Data analysis was done using SPSS Version 23. Logistic regression models were fitted to assess the association between dependent and independent variables. Statistical significance was set at 95% confidence interval (CI), with a P-value < 0.05.
Results
We studied a total of 70 patients’ files. These included 56 males for a M: F sex ratio of 4:1. Mortality rate was 5.7% (n = 4). Almost all (86.9%) of the patients developed complications and we had a 61.4% improvement in neurological status upon discharge. Being covered by health insurance was a predictor of improved neurological status (AOR = 15.04, 95%CI:2.90–78.20, P = 0.001) while being referred was a predictor of a stationary neurological status upon discharge (AOR = 0.12, 95%CI:0.03–0.52, P = 0.005). The average hospital stay was 20 days. We did not identify any predictors of lengthy hospital stay.
Conclusion
The prognosis of TLSI is comparable with those in other studies. The prognosis could be improved by reducing time spent at the periphery before referral, encouraging universal health insurance coverage, and improve on management to reduce complications
The null geodesics of charged and non–chargedblack hole in mimetic gravity
Authors: Haditale Maryam , Malekolkalami Behrooz
Published: October 2022

The null geodesics around the charged black hole spacetimes areinvestigated in the mimetic gravity framework when Einstein’s gravityis coupled to a nonlinear electromagnetic field. The photon paths innonlinear electrodynamics are geodesics of the effective metric whichis determined by the background metric and the particular nonlineartheory considered. The nonlinear effects are represented by a quadru-ple moment and appear as a correction term to Reissner Nordstrom(RN) metric and Reissner Nordstrom-de Sitter (RN–dS) in cylin-drical metric. Remarkably, the nonlinear effects prevent the circularorbits around black holes, and the presence of the mimetic field canchange the repulsive character of dS space to the attractive one. Also,the effect of the mimetic parameter manifests itself in the stronger orweaker gravity of the black hole.
Global Trends on Blastocystis sp. Research: A Scientometric Study
Authors: BİLDEN Alican , GURBUZ Esra , AYDEMIR Selahattin , UNLU Ahmet Hakan , EKICI Abdurrahman , ALKAN Sevil , ÇİÇEK Muttalip
Published: October 2022

Blastocystis sp. is the most common unicellular, luminal parasite in humans and animals. It has been associated with diarrhea and irritable bowel syndrome. This article describes the bibliometric research of articles published in Web of Science (WoS) database on Blastocystis sp. over a 51-year period. The VOSviewer visualization methodology was used for this study. Institutions, nations, international collaborations, journals, articles, authors, keywords, co-authors, co-citations, and citation rates from the WoS database formed the data of this study. A total of 1066 documents were found in the WoS database. Of which 773 were articles and only those publications were analyzed. The articles were cited 22,034 times in total and the mean Hirsch (H) index was 74. The countries with the highest number of articles were as follows: USA (n = 86; 11.125%), Singapore (n = 71; 9.185%), and Malaysia (n = 70; 9.056). Since 2000, there have been a limited number of articles and since 2014 there has been a minimum of 34 publications per year. The highest number of articles was published in 2021 (n = 76) and the highest number of citations (n = 3408) was in 2021. The leading affiliation according to the number of published articles was the National University of Singapore (9.185%), University Malaya (7.245%), and Nara Women’s University (5.304%). The USA, Singapore, and Malaysia have led scientific production on Blastocystis sp. Efforts should be made to help them develop interdisciplinary scientific research networks with these countries on Blastocystis sp.
A new method for quantifying treeline-ecotone change based on multiple spatial pattern dimensions
Authors: BIRRE Déborah , Feuillet Thierry , Lagalis Roman , Milian Johan , Alexandre Frédéric , Sheeren David , Serrano-Notivoli Roberto , Vignal Matthieu , Bader Maaike
Published: October 2022

Context
Treeline-ecotone spatial patterns and their dynamics reflect underlying processes. Changes in ecotone pattern may reflect changes in climatic drivers or land-use practices. However, characterizing these dynamics presents a major challenge, limiting our ability to map, understand and predict changes in the upper limits of mountain forests.
Objective
This paper proposes a new method using multiple pattern dimensions to describe treeline-ecotone spatial pattern shifts. This standardized protocol should be able to (i) distinguish different types of treeline-ecotone patterns within a large study area, (ii) characterize temporal pattern shifts in spatial pattern between two or more dates.
Method
We mapped alpine treeline ecotones (ATE) at 648 sites in the eastern French Pyrenees using aerial images from ~ 1955 and ~ 2015, identifying forest and non-forest areas at the hillslope scale. Extracted patch metrics were summarized using a Principle Component Analysis (PCA) and spatial pattern change was quantified from the shift in the PCA space and compared to elevational shifts.
Results
Three clusters of patterns were distinguished: diffuse, discrete and island-forming ATEs. Between 1955 and 2015, about half of the sites changed from one pattern cluster to another. Shifts into discrete ATEs were associated with smaller and negative elevational shifts, while shifts into diffuse ATEs coincided with the highest positive elevational shifts.
Conclusion
The proposed method allows a standardized and repeatable quantification of vegetation pattern change in alpine treeline ecotones based on historical aerial imagery. Seeing the importance of treeline-ecotone shifts for alpine biodiversity, we encourage the use of this protocol to better understand treeline dynamics at treelines globally.
Recording historical variations in agricultural areas caused by landslides and river floods through participatory mapping in the precordillera of the Atacama Desert, Chile
Authors: González-Pacheco Mauricio , Francos Marcos , Corvacho Oscar
Published: October 2022

In arid areas, rural communities can be affected by erosive phenomena caused by intense rainfall. By involving such communities in participatory mapping over the last few decades, our ability to analyse the effects of these phenomena has been enhanced. The aim of this study was to evaluate participatory mapping as a tool for spatially analysing agricultural variations caused by erosive phenomena, using local people to identify chronologies of physical events so we could analyse their effects on agriculture. The study was conducted in Laonzana, Tarapacá Valley, in northern Chile. We selected the participants for the participatory mapping using specific criteria, and carried out field activities in different phases, which allowed the identification, georeferencing and registration (through participatory mapping) of the information collected in the field and from the collective memories of the participants. Three periods were studied: 1) “before 1977” with 26 sites and covering 234,273 m2; 2) “between 1977 and 2012” with 6 sites and an area of 92,941 m2; and 3) “after 2012’ with three sites, covering 29,852 m2. This provided evidence for a decrease in the number of productive sites, these being limited to the vicinity of the village. The participatory mapping technique has become a useful tool in desert and mountainous areas with low population densities for recovering experiential information from communities. This participation contributes to the provision of examples for researchers, communities and government agencies to use in arguing for the need for cartographic information.
The problem of calculating the β-Bogoliubov coefficient in Non-Oscillating models
Authors: Haro Jaume , Areste Llibert
Published: October 2022

The calculation of the Bogoliubov coefficients is a key piece to obtain the reheating temperature of the Universe. In all cases this calculation is performed either in toy models where some derivative of the potential is discontinuous at some points or by making some approximations to the model. The result of these calculations is applied to more realistic models without checking if they really apply to this realistic model because the exact calculation of the Bogoliubov coefficients for a viable model, which is usually depicted by a smooth potential, requires a very complicated numerical calculation. Here we want to point out the difficulties that one encounters when trying to compute numerically these coefficients for a smooth potential without making approximations, which could lead to completely different results.
PACS numbers: 04.20.-q, 98.80.Jk, 98.80.Bp
Association between leptin and NAFLD: A Two-Sample Mendelian randomization study
Authors: Guo Ziwei , Chen Hening , Zao Xiaobin , Du Hongbo , Guo Yi , Jin Qian , Kong Deming , Liu Ruijia , Zhang Tingyu , Yun Zhangjun , Zhang Jiaxin , Li Xiaoke , Ye Yong'an
Published: October 2022

Background
Nonalcoholic fatty liver disease (NAFLD) etiology involves a complex interaction of genetic and environmental factors. Previous observational studies have suggested that increased leptin levels may be associated with a low risk of developing NAFLD, but the causal relationship remains unclear. Due to advances in genome-wide association studies (GWAS) and the discovery of Mendelian randomization (MR), we aimed to investigate the causal effect of leptin and NAFLD using MR analysis.
Methods
We performed a two-sample Mendelian randomization analysis (TSMR) using summary GWAS data from leptin (up to 50,321 individuals) and NAFLD (894 cases and 217,898 controls) in a European population. Genetic instrumental variables (InstrumentalVariables, IVs) that satisfied the three core assumptions of Mendelian randomization were selected. TSMR analysis was performed using the Inverse Variance Weighted (IVW) method, MR-Egger regression method, and Weighted Median (WM) method. To ensure the accuracy and stability of the study results, heterogeneity tests, multiple validity tests, and sensitivity analyses were conducted.
Results
The results of TSMR correlation analysis between NAFLD and leptin were IVW (OR: 0.3032; 95% CI 0.1181–0.7783; P = 0.0131), WM method (OR: 0.2816; 95% CI 0.0931–0.8678; P = 0.0273), MR-Egger regression method (P = 0.6955), and Among them, the IVW method and WM method showed P > 0.05, and the results were statistically significant. In addition, TSMR correlation analysis between NAFLD and circulating leptin levels adjusted for Body Mass Index (BMI) resulted in IVW (OR: 0.4416; 95% CI 0.2807–0.6948; P = 0.0004), WM method (OR: 0.4194; 95% CI 0.2279–0.7720; P = 0.0052), MR-Egger regression method (OR: 0.2023; 95% CI 0.0541–0.7562; P = 0.0389), P > 0.05, and the results were statistically significant. It is further demonstrated that increased leptin is causally associated with reduced risk of NAFLD, and leptin may serve as a protective factor for NAFLD.
Conclusions
In this study, we explored the causal association between leptin and NAFLD from a genetic perspective based on the GWAS database using TSMR analysis. Further studies are needed to explain the underlying mechanisms.
Power Prediction Method of PV System Based on Bifacial PV Modules
Authors: Li Yunqiao , Feng Yan
Published: October 2022

The increasing proportion of bifacial photovoltaic modules (Bi-PVM) in new projects makes the operation of photovoltaic system (PVS) more complicated, and it is difficult to accurately predict the power of the PVS. To solve this problem, this paper proposes a new power prediction method for PVS based on Bi-PVM. Firstly, we construct the equal proportion digital twin model of the example project, analyze the factors affecting the power generation performance of Bi-PVM by using the superposition principle, and construct the feature engineering according to the analysis results. Secondly, we reduce the parameter error caused by Bi-PVM to the prediction model by introducing the bifacial correction coefficient. On this basis, we establish a power prediction machine learning model based on bi-directional gated recurrent unit (Bi-GRU) network. Finally, we carry out a simulation experiment on Tensorflow machine learning platform. We use the actual operation data of a PV power station in Jiuquan, China to conduct simulation analysis under four weather types, namely sunny day, rainy day, snowy day and complex and changeable day, respectively, and demonstrate the correctness and excellence of the proposed method.
Design of Area Efficient Multilayer Reversible ALU with Energy Estimation using QCA
Authors: Venna Rama Krishna Reddy , Jayakumar G Durga
Published: October 2022

Quantum-dot Cellular Automata (QCA) is a transistor-less technology in which the information passes using a technique that requires the breeding of a polarization state from one circuit element to another, and computations take place without current. The reversible logic circuits potentially overcome the extreme power dissipation problem in CMOS circuits in quantum computing. In any computation system, the core part of the system is the Arithmetic and Logic Unit (ALU). This paper proposes a QCA technology-based reversible ALU using the Peres and Double Peres gates and implements multilayer architecture. It performs 29 operations, including logic operations, addition, increment, and subtraction. This ALU contains 199 cells with 2.5 clocks of latency. In comparison to existing research, the proposed multilayer ALU architecture improves the cell count and area by 20% and 66%, respectively. The total energy dissipation of the design is \(8.24e-02 eV\). QCA Designer 2.0.3 is used to simulating the proposed ALU architectures.
Is it necessary to prescribe the same dose to subclinical lesions as gross tumor volume in non-small-cell lung cancer? —a failure pattern analysis
Authors: Yu Yaner , Shui Yongjie , Zhou Xiaofeng , Liu Lihong , Yuan Zhijun , Wei Qichun
Published: October 2022

Background
As the standard practice of our institution, 60Gy is prescribed to PGTV and 54Gy to PTV in the radical radiotherapy of non-small cell lung cancer (NSCLC). We estimate whether this practice could achieve similar tumor control, and protect lymphocyte at the same time.
Methods
Failure patterns of 46 stage III NSCLC patients received radical radio-chemotherapy were analyzed. Target delineation criterion were as follows: GTV include primary tumor and involved lymph nodes, PGTV expanded from GTV with 5-8mm to compensate for genomic uncertainty. CTV include high-risk area, PTV was extended from CTV with set-up error. 60Gy was prescribed for PGTV, 54Gy for PTV over 30 fractions. The relationship between lymphopenia during radiotherapy and dose-volume parameter was evaluated using Spearman’s correlation analysis.
Results
With median follow-up of 21.06 months, 22 local-regional recurrence were evidenced, 13 patients have in-field recurrence, one patient failure marginally, and the other 8 patients have out-of field recurrence. Lymphocyte is the most sensitive cell to radiation, lymphopenia during radiotherapy was associated with both PTV(r = 0.489, p = 0.003) and PGTV(r = 0.313, p = 0.076), with larger volume predicted severe lymphopenia. In addition, we observed Lung V(5), V(10) and most of heart or aorta DVH parameters (from V10-V50) are important predictors for lymphocyte nadir.
Conclusions
Delivered 54Gy to subclinical lesions does not compromise marginal recurrence risk, at the same time lower severe radiation-induced lymphopenia risk. This finding supports further exploration of dosage reduction to CTV in locally advanced NSCLC.
The comparison of short-term outcomes between robotic and laparoscopic radical distal gastrectomy
Authors: Song Yang , Zhang Qianshi , Feng Zhen , Wang Bo , Ren Shuangyi
Published: October 2022

Purpose: The study's objectives were to compare the short-term outcomes of robotic radical distal gastrectomy(RDG) with laparoscopic radical distal gastrectomy(LDG) for patients with gastric cancer and investigate the learning curve of RDG.
Methods: The cumulative sum (CUSUM) method was used to retrospectively analyze consecutive gastric cancer patients undergoing RDG between January 2019 and May 2021. The duration of surgery, clinical-pathological characteristics and short-term outcomes were evaluated according to the two phases of the learning curve (learning period versus mastery period). We also compared the clinical-pathological characteristics and short-term outcomes between cases in the mastery period and LDG.
Results: Date from 290 patients were included in this analysis, 135 RDG and 155 LDG cases. The learning period was 20 cases. There were no significant differences in clinical-pathological characteristics between the learning period and mastery period. Compared with the learning period, the mastery period had a significant reduction in total operation time, docking time, pure operation time, and estimated blood loss, and a significant increase in hospital costs (P=0.000, 0.000, 0.000, 0.003, and 0.026, respectively). Compared with LDG, robotic cases in mastery period had a longer operative time, shorter first postoperative flatus time, and more hospital costs (P=0.000, 0.005, and 0.000, respectively).
Conclusions: RGD may fasten to recover gastrointestinal function faster after the operation, can be mastered easily after a reasonable number of cases, and was associated with safe and satisfactory short-term outcomes before and after the learning curve.
A review on Sequential extraction of metals bound particulate matter and their health risk assessment
Authors: Rajouriya Kalpana , Pipal Atar Singh , Taneja Ajay
Published: October 2022

Sequential Extraction Procedure (SEP) is a method widely used to extract metals and metalloids from Particulate Matter (PM) based on their solubility in different reaction media. This extraction procedure is used to determine the actual mobility of metals present in the environment. A detailed discussion on the significance of sequential extraction analysis is also being given in this scientific document. This review includes different aspects related to the fractions obtained (exchangeable: F1, reducible: F2, oxidizable: F3, bound to organic matter: F4, and residual fraction: F5) during the SEP. The use of each reagent involved in the fractionation process of PM is also discussed briefly. Finally, the present up-to-date information given by different researchers in various fields of atmospheric chemistry along with the possible future developments is also part of this scientific review. The current review also focuses on the relation between SEP and mathematical expressions (bioavailability, source apportionment, and health risk assessment by the USEPA method). It is revealed from the previous studies that Cd and Zn are highly enriched, mobile as well as highly bioavailable in the environment and poses more risk to the human being. The Cr and As showed carcinogenic nature and hence pose carcinogenic diseases in humans. Whereas, Mn and As are non-carcinogenic in nature for children and adults and thereby both pose a non-carcinogenic disease threat to the population.
Metataxonomic analysis of the uterine microbiota associated with low fertility in dairy cows using endometrial tissues prior to first artificial insemination
Authors: Yagisawa Takuya , Uchiyama Jumpei , Takemura-Uchiyama Iyo , Shun Ando , Ichii Osamu , Murakami Hironobu , Katagiri Seiji , Matsushita Osamu
Published: October 2022

Background: The deterioration in reproductive performance associated with low fertility leads to significant economic losses in dairy farms. Some causes of low fertility have not been identified and adequate countermeasures have not been undertaken. In recent years, the uterine microbiota has begun to attract attention as a possible cause of unexplained low fertility. This study analyzed the uterine microbiota associated with low fertility in dairy cows by 16S rRNA gene amplicon sequencing using endometrial biopsies sampled from cows that had passed the voluntary waiting period before the first artificial insemination (AI).
Results: First, the uterine microbiota of 69 cows from four farms was analyzed regarding parity and AI frequency to conception, together with factors including housing style and feeding management, as each farm was managed differently. The analysis of microbial diversity revealed differences with respect to feeding management and housing style, but not parity and AI frequency. Next, to avoid the effect of housing style and feeding management, we performed the microbiota analysis in relation to parity and AI frequency in 31 cows from one farm. According to the microbiota diversity analysis, the weighted UniFrac beta diversity metric was correlated with AI frequency, but not with parity. A differential abundance analysis of AI frequency found that the abundance of the Arcobactergenus was increased, whereas the co-occurrence network analysis showed that Arcobacter cooperated with several other bacterial taxonomy units. A comparison of the network of the co-occurrence abundance patterns of normal and low-fertility cows (£3 and ³4 AIs, respectively) showed that bacterial associations related to low fertility, including the Arcobacter association, were observed in low-fertility cows. Finally, the examination of the ratio of the Arcobacter-hub model among the tested farms revealed that it was present to a certain extent, despite the skew toward certain farms. Thus, the Arcobacter genus may be key bacteria in the network module for low infertility in certain farms.
Conclusion: This study provided new insights into the relevance of the uterine microbiota as a cause of low fertility, which significantly reduces cows’ reproductive performance.
Phenyl Conjugation Effect on Fe 3+/2+ Formal Potential of FeN 4 -macryclic Complex
Authors: Gill Ravindra , Das Dipak Kumar , Kumar Anuj
Published: October 2022

The monitoring of shifting of the redox potential of macrocyclic complexes towards anodic or cathodic regions, which acts as a mediator in many electrocatalytic events, is made possible by inserting electron donating or withholding groups into their frameworks. Herein, using a template strategy, two [14]-membered N4-macrocyclic complexes (denoted as complex A and complex B) with similar molecular cores but different phenyl moieties were prepared and characterized using multiple characterization techniques. The characterization results suggested a saddle-shaped geometry for these complexes, which might be due to the steric repulsions between the benzenoid and amidic moieties on the macrocyclic framework, as also supported by theoretical computations. Further, to investigate the electrochemical behaviors of these complexes, cyclic voltammetry was used and found that the Fe3+/2+ redox potential was systematically shifted in anodic direction with the increment of phenyl moieties on the [14]-membered N4-macrocyclic core. DFT calculations indicated the down-shifting in the most occupied molecular orbital due to the increased phenyl conjugation, which could be correlated with the shifting of Fe3+/2+ redox potential. Biological evaluation of these complexes has also been carried out.
Using Big Data and Network Theory to Inform Decision-making on COVID-19 in Bogotá
Authors: Feged-Rivadeneira Alejandro , González-Casabianca Felipe , Parra-Salazar Andrea , Salcedo-Ortiz Juana , Andrade-Rivas Federico , Cárdenas Pablo , Morales Álvaro , Damelines-Pareja Juliana , Rios-Oliveros Diana , Salazar Carolina , Usma Santiago , Muñoz Marina , Patiño Luz , Ballesteros Nathalia , Ramírez Juan , Ángel Andrés , Rodríguez Tomás , Vega Jaime Cascante , Galindo-Silva Hector , Majerowicz Stephanie , Corredor Vladimir
Published: October 2022

After the initial year of the pandemic (2020), a need for Non-Pharmaceutical Interventions (NPIs) that did not imply lockdowns became evident, particularly in locations where human mobility was greatly restricted like in South America. In this research, we propose a multidisciplinary framework to combine findings from diverse academic fields (epidemiology, public health, urban studies, molecular biology) to inform decision making in public health. Furthermore, we designed and implemented NPIs that minimized the effect on human mobility while mitigating viral transmission in Bogota, a city of ~10 million people in a middle-income country. Our results suggest that near real time information can and should be used to design, assess and optimize the effectiveness of public health interventions to reduce disease burden while minimizing socioeconomic disturbances.
Identification of Biomarkers in Affected Hair Follicles from Chronic Discoid Lupus Erythematosus by Weighted Gene Co-Expression Network Analysis
Authors: Chen Qitao , Tao Qiuwei , Li Yuqian , Shao Guanghui , Zhu Jing , Zhu Qilin , Li Zhongming , Du Xufeng
Published: October 2022

Chronic discoidal lupus erythematosus (CDLE) is an inflammatory skin disease characterized by localized, round, red, patchy skin lesions, which often occur on the head. Inflammatory cells often show an infiltration pattern targeting hair follicles, leading to alopecia. Our study aims to analyze the characteristics of gene expression data from hair follicle samples by bioinformatics methods, and the representative genes will be validated in data from skin samples with the same disease. The gene expression profile GSE119207 was obtained from the Gene Expression Omnibus (GEO) database as an experimental set, including microarray gene expression data of 4 healthy human hair follicles and 7 lesional and non-lesional hair follicles with CDLE. Gene profile GSE81071 included 13 healthy scalp samples and 47 scalp samples from CDLE lesions as the validation set. The experimental set was analyzed by differential gene expression analysis and WGCNA, respectively, and the intersection was taken to screen the key genes. The key genes were analyzed by GO and KEGG analysis to determine the related biological processes and pathways. The protein-protein interaction network of key genes was established by string and visualized by Cytoscape, and hub genes were obtained by cytoHubba. The acquired hub genes were used as ROC curve in the validation set to verify the consistency, and the related mirnas predicted by the hub genes were obtained by miRNet (version 2.0). Finally, cibersort was used to explore the infiltration pattern of immune cells in the hair follicles of CDLE. Through this process, we found that type I interferon response-related genes activated by the RIG-1 and IL-17 signaling pathways were significantly up-regulated, and the involved hub genes were also consistently upregulated in skin tissues. This process may involve the involvement of follicular helper T cells (Tfhs).
Comprehensive classification assessment of GNSS observation data quality by fusing k- means and KNN algorithms
Authors: Li Mengyuan , Huang Guanwen , Wang Le , Xie Wei
Published: October 2022

The observation data is the basis for the global navigation satellite system (GNSS) to provide positioning, navigation and timing (PNT) service, and the observation quality directly determines the performance level of PNT service. At present, the analysis of GNSS observations quality is partial and can only be based on a single index assessment. GNSS observation quality is difficult to analyze comprehensively by fusing multiple indicators. To solve the above problem, the supervised and unsupervised machine learning algorithms are applied, and a new comprehensive and classification method of GNSS observations quality based on the k-means clustering algorithm (k-means) and K-nearest neighbor algorithm (KNN) was proposed. The four core index features of GNSS observations, including data integrity rate, carrier-to-noise-density ratio (CNR), pseudorange multipath and the number of observations per slip, were selected to construct the sample dataset. The sample set was unsupervised clustered based on the k-means algorithm, and the classification label of GNSS observations quality was obtained. Then KNN algorithm was used to construct a comprehensive classification and evaluation model for GNSS observations quality. The data of 30 MGEX stations in the Asia-Pacific region in 2019 were selected for modeling analysis. The experiment results show that: (1) a strong correlation has been revealed between pseudorange multipath, CNR and the number of observations per slip. (2) The average classification correctness rate of the new model was over 90% by -fold cross-validation. (3) The new model can effectively realize the automatic evaluation and classification of GNSS observations quality and easily distinguish the superiority and inferiority of the station observations. The relevant results provide a new idea for the automatic classification and assessment of GNSS observation quality.
Deterministic and probabilistic health risk assessment of toxic metals in daily diets of residents in industrial regions of northern Ningxia, China
Authors: Wang Yan , Cao Deyan , Qin Jiaqi , Zhao Siyuan , Lin Jianzai , Zhang Xi , Wang Junji , Zhu Meilin
Published: October 2022

This study was designed to investigate the toxic metals (aluminum (Al), arsenic (As), chromium (Cr), cadmium (Cd), copper (Cu), nickel (Ni), lead (Pb), and zinc (Zn)) concentrations in drinking water and different foodstuffs (cereals, meat, beans, potatoes, solanaceous fruits, vegetables, and fruits) and then estimate the potential health risks of toxic metals via consumption to the local residents in industrial regions of northern Ningxia, China. Inductively coupled plasma atomic emission spectrometry was performed to detect toxic metal concentrations. According to the results, the concentrations of As, Cr, Ni, Pb, and Zn in fruit samples exceeded the standard limits. Pb was the most common toxic metal detected in drinking water, cereals, beans, potatoes, solanaceous fruits, vegetables, and fruits.The results of deterministic assessment of health risks showed that the total noncarcinogenic health risk value of dietary intake of toxic metals by the local population was 5.6106, indicating that toxic metals pose a high noncarcinogenic risk to residents under the current daily diet exposure. The order of noncarcinogenic health risk values of various foods analyzed was as follows: HIcereals (1.2104) > HIsolanaceous fruits (0.9134) > HIvegetables (0.8726) > HIfruits (0.8170) > HImeat (0.7269) > HIdrinking water (0.6139) > HIbeans (0.2991) > HIpotatoes (0.1573). The total carcinogenic health risk from exposure to toxic metals through dietary intake was 9.98×10− 4, indicating that the total cancer risk value of residents is beyond the acceptable range under the current daily dietary exposure, and implies a high risk of cancer. The order of carcinogenic health risk (R) was Rdrinking water (2.34×10− 4) > Rmeat (2.11×10− 4) > Rsolanaceous fruits (1.89×10− 4) > Rfruits (1.88×10− 4) > Rcereals (1.36×10− 4) > Rpotatoes (2.44×10− 5) > Rvegetables (1.51×10− 5) > Rbeans (0.00). Probabilistic assessment results showed that 98.83% of the population would suffer severe noncarcinogenic risk and 87.02% would suffer unacceptable carcinogenic risk. Sensitivity analysis showed that drinking water, local cereals, vegetables, and fruits were the major contributors to health risks. Our results indicated that daily dietary exposure of residents in industrial regions of northern Ningxia posed a serious threat to human health, and appropriate strategies should be adopted to prevent toxic metal contamination.
Kooperation zwischen ‹Zuarbeit›, ‹Beratung› und ‹Entwicklungspartnerschaft›
Authors: Rau Franco , Gerber Lars , Grell Petra
Published: October 2022

Die Zusammenarbeit von Wissenschaft und Praxis in Schulentwicklungsprojekten steht vor vielfältigen Herausforderungen. Der Beitrag analysiert und reflektiert die Ausgestaltung von Kooperationsstrukturen und Kommunikationswegen in entwicklungsorientierten Forschungsprojekten zur Schulentwicklung am Beispiel des Darmstädter Modellschulprojekts. In diesem gestaltungs- und entwicklungsorientierten Forschungsprojekt wurden drei Schulen auf ihrem Weg zu digital souverän agierenden und im Schulalltag ‹digital literacy› vermittelnden Schulen forschend begleitet: eine integrierte Gesamtschule, eine berufliche Schule sowie eine Sprachheilschule. Die Kooperation erfolgte über zwei Jahre. In der Betrachtung schulischer Teilprojekte beschreibt der Beitrag drei unterschiedliche Kooperationsmodi zwischen Praktiker:innen und Wissenschaftler:innen, die Entwicklungsprozesse für alle Beteiligten ermöglichten: «Zuarbeit», «Beratung» und «Entwicklungspartnerschaft». Auf der Basis der vorgestellten Kooperationsmodi wird sichtbar, mit welchen Herausforderungen und Konflikten die Personen aus wissenschaftlicher und praktischer Perspektive konfrontiert waren. Anstatt lediglich zwischen erfolgreicher oder nicht erfolgreicher Kooperation zu unterscheiden, eröffnen die skizzierten «Grade» der Kooperation eine Heuristik, um Formen der Zusammenarbeit zwischen Praktiker:innen sowie Forschenden reflektieren wie auch aktiv und sensibel gestalten zu können.
Manifestações Clínicas dos Granulomas Piogênicos: Série de Casos
Authors: Aguiar Priscila Lins , Maria Flores Moraes Fabienne , Silva Izaias Manoel da , Muniz Rafaela Pereira Deschamps , Sousa Junior José Romero Souto de , Silva Neto Joaquim Celestino da
Published: October 2022

O granuloma piogênico é uma hiperplasia inflamatória da pele e da mucosa oral. Seu fator etiológico é multifatorial e está frequentemente associado a um fator reacional, devido às agressões repetitivas, microtraumatismos e irritação crônica local, possuindo também correlação com distúrbios hormonais. A gengiva é o local predominante, seguido por lábios, língua, mucosa bucal e palato duro. Apresentam-se geralmente com as seguintes características: macios, indolores e de coloração vermelho profundo a roxo-avermelhado. Ocorre em uma ampla faixa etária de 4 a 93 anos, com maior incidência na segunda e quinta décadas e as mulheres são ligeiramente mais afetadas do que os homens. O tratamento de escolha consiste na remoção do agente irritante associado ou a exérese total da lesão. Sendo assim, objetivo do nosso trabalho é descrever relatos de 4 casos clínicos de granuloma piogênico, bem como discutir as diferentes manifestações clínicas e o tratamento adequado para essa lesão.
Fantastic Marine Creatures From the Late Renaissance: Pietro Tacca’s fountains in Florence’s Piazza della Santissima Annunziata
Authors: Verdiani Giorgio , Formaglini Paolo , Giansanti Filippo
Published: October 2022

In the 1550s Florence’s water supply was upgraded through the construction of a new aqueduct. Prior to that, water needs were supported by the remnants of a Roman aqueduct and by wells and cisterns. The new infrastructure increased the amount of available water and allowed for the construction of fountains in the city’s main squares, with themes principally derived from Greek and Roman mythologies. In 1641 the twin Mostri Marini (‘Marine Monsters’) fountains designed by Pietro Tacca were installed in the Piazza dellaSantissima Annunziata. The bronze and stone statues presented fantasy creatures whose flexuous shapes suggested moving fluid. But while these statues complemented the square, they were not originally planned for the location, having been intended for placement in the main Tuscan harbour town of Livorno. This study draws on high-resolution photogrammetry to analyse the structures with this specific digital survey being presented for the first time.
Floodwater Ghosts as Social Criticism: A horror film and Tropical Storm Ondoy
Authors: Biana Hazel
Published: October 2022

Typhoon Ketsana, known in the Philippines as Tropical Storm Ondoy, hit the nation’s capital more than a decade ago. Metro Manila and its neighbouring rural areas were submerged in floodwaters up to 20 metres high resulting in 921 fatalities and $1.15 billion in damages. Most of those who survived the extreme weather event have various Ondoy stories to tell. In 2011 the popular Philippine horror anthology film series Shake, Rattle & Roll portrayed Ondoy victims as floodwater ghosts in a narrative included in instalment 13, in an episode entitled Rain, Rain, Go Away (RRGA). The floodwater ghosts are chilling reminders of various intersecting issues plaguing the country such as child labour, poor infrastructure, graft and corruption, the lack of proper weather forecasting techniques and equipment, and many others. The ghosts also represent how the most vulnerable sectors suffer from such water disasters, and invite possible discourses on actions that need to be taken against the detrimental effects of extreme weather events on the Philippine islands.
Islandness as Narratives of Relation
Authors: Waite S. G.
Published: October 2022

This article uses literature on islands and islandness, coloniality, creole identity, indigenous ontology and settler studies to abstract a typology of islandness. The article frames islandness as a product of narratives of relations within and with islands that produce Autochthonous, Settler and Creole islandnesses. The article engages with islands as sites of relational spatialities, following Vannini and Taggart (2013). Those relational spatialities are understood to be produced by, and reproduced through, intergenerational narratives. Using Australia as an illustrative reference, the article identifies themes related to each type of islandness, not as universals but as examples of a type. The article concludes by proposing that the typology can be engaged in validating the variety of islandness narratives that emerge from the process of collective identification within island spaces.
REVIEW ON INFANT ORAL HEALTH
Authors:   Post Graduate Student, Department of Pediatric and Preventive Dentistry, DivyaJyoti College of Dental Sciences and Research., Yadav Jeetu , Somani Rani ,   Professor and Head, Department of Pediatric and Preventive Dentistry, DivyaJyoti College of Dental Sciences and Research., P. Deepa ,   Post Graduate Student, Department of Pediatric and Preventive Dentistry, DivyaJyoti College of Dental Sciences and Research., Kumar R. Sarath ,   Post Graduate Student, Department of Pediatric and Preventive Dentistry, DivyaJyoti College of Dental Sciences and Research., M.S Serene ,   Post Graduate Student, Department of Pediatric and Preventive Dentistry, DivyaJyoti College of Dental Sciences and Research., S. Anaswara ,   Post Graduate Student, Department of Pediatric and Preventive Dentistry, DivyaJyoti College of Dental Sciences and Research.
Published: October 2022

Themedicalliteratureprovidessomeinsightintothebenefitsofananticipatoryguidance program. Parents are extremely satisfied with the interaction fostered by thisapproach.Additionally,they enjoy thefunctional approach to educationthatdealswith specific events in their own family. It may be this communication about a vitalinterest that makes the process so successful. Pediatric dentists have seen a dramaticincrease in their market share of childrens dental care, and some of this canbeattributed to their tendency to see children much earlier and thus capture parentsinterest in important dental milestones and the future effects of habits and behaviors.Applyinganticipatoryguidancetodentalpreventiveeducationisanorganizedwayfor all dental providers to enjoy the attention of parents and be more successful inpreventive dentistry. Early dental intervention using an individualized approach suchasanticipatoryguidancemaybethe next frontierin dental caries reduction.
RESEARCH STRUCTURE OF A STUDY ON MICRO FINANCE, FINANCIAL INCLUSION AND WOMEN EMPOWERMENT WITH REFERENCE TO SELECTED URBAN AREAS IN SRI POTTI SRIRAMULU NELLORE DISTRICT, ANDHRA PRADESH
Authors: Harita M. , Amruth Prasad Reddy A.
Published: October 2022

Financial system of the country is backbone to the countrys growth. In the context of developing nations, a well-designed microfinance programme is seen as a successful institutional instrument for promoting socioeconomic development of economically disadvantaged sectors of society, particularly women. Women, in general, have difficulties obtaining institutional credit due to a lack of assets that may be used as security. Microfinance, as an alternate delivery method, focuses on women since women are more likely than males to be credit limited.The present paper is the blue print of the research entitled A study on micro finance, financial inclusion and women empowerment with reference to selected urban areas in Potti Sriramulu Nellore district, Andhra Pradesh.
AN ANALYSIS OF INDIAS TRADE INTENSITY INDEX WITH UAE
Authors:   Assistant Professor & Head, Department of Economics, Indira Gandhi College of Arts and Science, Puducherry -605009., Saravanan S.
Published: October 2022

Today no country on the earth (planet) is completely independent on its own resources. Every one of the countries of the world are some way or another associated on others, in light of the fact that each country has its own normal assets, environment, geological circumstances and wellsprings of energy. Worldwide relationship is the principal element of the present worldwide economy. Exchanging commodities among India and UAE have existed since antiquated times. Indo-UAE exchange has filled massively as of late. Numerous factual exchange lists are accessible to gauge exchange between two nations. One of them is the International Trade. The International Tradeshows up in two structures, namely exports and imports list. A couple of studies have done to investigate complexities of the International trade connection between the two nations. Under such situation this paper examines the significant patterns of International Trade Relations.. An endeavor is made here to look at the Indias Trade Intensity with UAE for the period from 2012 to 2021. The paper likewise proposes measures to enhance International trade relations among India and UAE. Time series information has been utilized to quantify Trade Intensity Index (TII). The discoveries of the review uncover that Indias exchange with UAE is more extraordinary in examination with its other exchanging accomplices.