bluuebunny/crossref_metadata_2025 huggingface dataset:
APR-246 increases tumor antigenicity independent of p53
Authors: Michels Judith , Venkatesh Divya , Liu Cailian , Budhu Sadna , Zhong Hong , George Mariam M , Thach Daniel , Yao Zhong-Ke , Ouerfelli Ouathek , Liu Hengrui , Stockwell Brent R , Campesato Luis Felipe , Zamarin Dmitriy , Zappasodi Roberta , Wolchok Jedd D , Merghoub Taha
Published: October 2023

We previously reported that activation of p53 by APR-246 reprograms tumor-associated macrophages to overcome immune checkpoint blockade resistance. Here, we demonstrate that APR-246 and its active moiety, methylene quinuclidinone (MQ) can enhance the immunogenicity of tumor cells directly. MQ treatment of murine B16F10 melanoma cells promoted activation of melanoma-specific CD8+T cells and increased the efficacy of a tumor cell vaccine using MQ-treated cells even when the B16F10 cells lacked p53. We then designed a novel combination of APR-246 with the TLR-4 agonist, monophosphoryl lipid A, and a CD40 agonist to further enhance these immunogenic effects and demonstrated a significant antitumor response. We propose that the immunogenic effect of MQ can be linked to its thiol-reactive alkylating ability as we observed similar immunogenic effects with the broad-spectrum cysteine-reactive compound, iodoacetamide. Our results thus indicate that combination of APR-246 with immunomodulatory agents may elicit effective antitumor immune response irrespective of the tumor’s p53 mutation status.
Preliminary investigation of a significant national Cryptosporidium exceedance in the United Kingdom, August 2023 and ongoing
Authors: Peake Lewis , Inns Thomas , Jarvis Christopher , King Grace , Rabie Hussein , Henderson Joan , Wensley Adrian , Jarratt Reece , Roberts Christopher , Williams Christopher , Orife Oghogho , Browning Lynda , Neilson Matthew , McCarthy Caitlin , Millar Paul , Love Nicola , Elwin Kristin , Robinson Guy , Mannes Trish , Young Nick , Chalmers Rachel , Elson Richard , Vivancos Roberto
Published: October 2023

Routine laboratory surveillance has identified an unprecedented and ongoing exceedance of Cryptosporidium spp. across the United Kingdom, notably driven by C. hominis transmission, since 14 August 2023. Information from 477 reported cases in England and Wales, followed up with a standardised exposure questionnaire as of 25 September 2023, identified foreign travel in 250 (54%) of 463 respondents and swimming in 234 (66%) of 353 cases. A significant, common exposure has not yet been identified in first analyses.
The Organization and Activities of the YANG HO DAN(養虎團) in the Period of Political Situation of Korean Liberations
Authors:   The Association for Korean Modern & Contemporary History, CHOI In-ho
Published: October 2023

During the period of political situation of Korean liberations, right-wing youth acted as a front of right-wing political forces. Youth were at the center of the confrontation of each political force. Therefore, in order to confirm the appearance of the political force confrontation, an analysis of the organizations that were active right after Liberation in necessary. This article studied the organization and activities of the right-wing youth organization YANG HO DAN which was active in Seoul from November 1945 to December 1946. To confirm this, the history of major figures was checked, and the process of the formation and activities of the YANG HO DAN were analyzed.
Changing perceptions of the colonial situation before and after the 3.1 Movement of 1919 and the search for ‘proactive’ colonial management
Authors:   The Association for Korean Modern & Contemporary History, YOON Min-hyuk
Published: October 2023

This study aims to shed new light on the colonial system in the 1920s by examining the process of colonial governance ‘reform’ after 1919. The colonial governance ‘reform’ attempted after the March 1 Movement is described as gradualism and extensionism, a process in which Takashi Hara's political ideals are realised. However, there were ‘reform’ initiatives before the March 1 Movement, not only by Hara but also by the Bungei and the Army, which were thwarted by the March 1 Movement. In response, Hara suspended his ideals and turned to utilising the inertia of existing colonial rule. The Yamagata clan, which Hara hoped to capitalise on, recognised the need for ‘reform’ but were lukewarm about going to Korea, while the Terauchi clan opposed reform itself. As a result, the ‘reform’ repeatedly delayed and delayed. So exposing a policy vacuum in Hara’s ‘ideal’ colonial ruler. It was the Taiwanese precedent and the ‘activist’ colonial management of Goto Shinpei that filled this void. This method of colonial governance through aggressive financial injections and inspections was embraced by Takashi Hara and Rentaro Mizuno. The colonial ‘reform’ attempted after the 3.1 Movement was a Korean version of Goto Shinpei’s activist colonial management, which Hara and Mizuno embraced and sought to apply the Taiwanese precedent to Korea.
When did topknots disappear in Korean?
Authors:   The Association for Korean Modern & Contemporary History, SEO Dong-il
Published: October 2023

When did topknots, called sang-tu, disappear in Korean? People generally say it probably disappeared after the early 1930s because Imperial Japan had banned it as a policy at the time in colonial Korea. Is that true? The case of the movement for the improvement of living conditions生活改善運動 in the late 1920s calls for a reexamination of such academic understanding. This research is expected to help find internal causes of social changes in colonial Korea.
It is true that Japanese Government-General of Korea weakened Korean traditional culture like topknots, white clothes, and so on after the wartime. But Chosun-ilbo(朝鮮日報), Shin-gan-hwe(新幹會) carried out the movement for the improvement of living conditions and campaigned short hair(斷髮) from the late 1920s to the beginning of 1930s and the attempts were partially successful. This shows the multi-layered causes of social changes in colonial Korea, related to Korean people’s demands as well as the policy intervention and physical forcing by the Japanese government-general of Korea.
THE GIVING OF STRETCHING EXERCISE TO CHANGES IN LEVELS OF DYMENORRHES IN ADOLESCENT FEMALE CLASS VIIAT SMPN 1 PRAMBON, NGANJUK DISTRICT
Authors: Astutik Puji
Published: October 2023

Dysmenorrhea is a menstrual disorder that is often experienced by young women, if left untreated it will interfere with learning concentration. Stretching exercise is an alternative to overcome dysmenorrhea. The purpose of this study was to determine the effect of giving stretching exercise on changes in the level of dysmenorrhea in class VII young women at SMPN 1 Prambon, Nganjuk Regency. The research design used a pre-experimental design (one group pre-test-post test design) which was carried out November 5 – 18, 2022. The population consisted of 40 young women, using a purposive sampling technique to obtain a sample of 30 respondents. The independent variable of the research is the giving of stretching exercise, while the dependent variable of the research is the change in the level of dysmenorrhea. Collecting independent variable data with SOP and dependent variable with Numeric Rating Scale. Statistical test using Wilcoxon Signed Ranks with a significance level of α = 0.05. The results of the study before doing stretching exercises almost half experienced moderate pain as many as 12 (43%) of 30 respondents, and after doing stretching exercises almost half experienced mild pain, namely 14 (47%) of 30 respondents. The results of the Wilcoxon Signed Ranks statistical test showed ρ value = 0.014 < α = 0.05 so Ha was accepted, which means that there is an effect of giving stretching exercise on changes in the level of dysmenorrhea in class VII young women at SMPN 1 Prambon Nganjuk. Based on the results of the study, stretching exercise affects changes in the level of dysmenorrhea in female adolescents. This is because when doing stretching exercises the body will produce endorphins. Endorphins are produced in the brain and spinal cord. This hormone can function as a natural sedative that is produced by the brain, causing a feeling of comfort that can relieve pain.
Effect of Industry Factors(Industry Competition Intensity, Industry Entry Barriers, Industry Concentration) on Relationship between Strategic Deviance and Firm Value
Authors:   Korea Accounting Information Association, Kim Ye-Kyoung , Park Won
Published: October 2023

[Purpose]This study examines the effects of industry－specific factors such as competition intensity, entry barriers, and concentration on strategic deviance and firm value. Prior studies in this field show that strategic deviance is an opportunism and financial opacity, cost of capital, stock price crash risk. However, in an industry where competition is intensified and change is required, it seems that if a firm makes a strategic deviation for survival and growth, it has a positive effect on firm value.
[Methodology]Industrial factors were measured using the intensity of industrial competition, barriers to entry, and degree of monopoly used in the study by Jung et al.(2014), and strategic deviance was measured used by Tang et al.(2011). In addition, the Tobin Q was used for firm value, and the target for analysis was selected non－financial listed firms with December settlement of accounts from 2011 to 2020.
[Findings]As a result of the analysis, it was found that strategic deviance and industry factors affect firm value. It was found that the industry competition and the concentration affect strategic deviance and Tobin Q. Strategic deviance was found to have a positive effect on corporate value as the intensity of industry competition intensified and the industry concentration was low.
[Implications]This prior studies on strategic deviance showed negative results on firm value or performance from the CEO’s opportunism. This study proposes that strategic deviance effects relation to the factors of industries.
Computing the Cost Economics of Agricultural Machinery in Farms
Authors:   1Departmant of Agricultural Engineering, Saveetha Engineering College, Thandalam, Chennai - 602 105, a Tajuddin , m Parthiban ,   2Department of Physical Sciences, Agricultural Engineering College and Research Institute, Tamil Nadu Agricultural University, Coimbatore-3, b Suthakar ,   3Department of Farm Machinery, Agricultural Engineering College and Research Institute Tamil Nadu Agricultural University, Kumulur - 621 712
Published: October 2023

Farm mechanization accelerates faster agricultural growth through the efficient use of machines by ensuring the timeliness of agricultural operations, reducing the cost of operation, and by reducing human drudgery. Farm machinery ownership and operating costs represent a substantial portion of total crop production expenditure. Cost economics becomes important for farm machinery managers to control the machinery costs per hectare. The manual procedure of determining the cost economics of agricultural machinery is a time-consuming process and finally making a smart decision whether to buy a farm machine or to go for custom hiring is a cumbersome process. The web application was designed for naive users to help the users in making the decision. The user is asked to enter the basic data pertaining to the farm machine, and the software decides whether to acquire the farm machine or to go for custom hiring. The cost of operating a farm machine can be computed with ease by using the web application. Further, the break-even-point, payback period and benefit-cost ratio can also be determined with a single click
Uma Proposta de Intervenção com o Gênero Charge no 9º Ano do Ensino Fundamental
Authors: Moraes Dione Márcia Alves de
Published: October 2023

Este trabalho apresenta uma discussão sobre o gênero charge e como esse pode ser utilizado como instrumento para o ensino e aprendizagem da língua materna em uma turma do 9º ano do Ensino Fundamental a partir de uma sequência didática. Embasado em teóricos como Volóchinov (2018), Bakhtin (2003), Dolz, Noverraz e Schneuwly (2007), Romualdo (2000), entre outros, esta pesquisa visa contribuir para a formação (inicial e continuada) do professor. Os resultados aspirados são um enriquecimento no ensino e aprendizagem da língua portuguesa, auxiliando no ensino e aprendizagem de língua portuguesa e na formação do aluno, já que a metodologia propõe a leitura crítica, análise linguístico-discursiva e produção escrita.

Palavras-chave: Ensino da Língua Materna, Sequência Didática, Gênero Charge.
Pesquisa Crítica de Colaboração: Breve Análise Metodológica
Authors: Nogueira David Juglierme Alves , Tamashiro Jândela Cristiani Guilherme dos Santos
Published: October 2023

Este artigo tem como objetivo compreender o sentido e o significado que uma professora do 4º ano, do ensino fundamental I de uma escola municipal em uma cidade do estado de São Paulo atribui à situação de exclusão-inclusão social-escolar (Fidalgo, 2006, 2018; Fidalgo & Magalhães, 2017) de alunos migrantes bolivianos em contextos educacionais. O foco está em uma professora e em seu trabalho desenvolvido. Para isso, utilizaremos a Pesquisa Crítica de Colaboração - PCCol (Magalhães, [1996] 2006a, 2010, 2014, 2017, 2018, 2019), como metodologia deste estudo, pois a partir dessa metodologia compreendemos os participantes de uma pesquisa como colaboradores críticos que, contribuem para a transformação de seu contexto e para o debate sobre o processo educacional de alunos migrantes. Nessa direção, este estudo está embasado na Teoria Histórico-Cultural [social] de Vygotsky ([1924] 1997; [1934] 2009; [1932] 1982-1984), por meio dos conceitos de sentido e significado que são construídos coletivamente no ambiente escolar e que nos permite olhar e analisar como os envolvidos se vêem, analisam seus papéis e os dos outros, assim como seus processos de exclusão-inclusão. Os dados foram produzidos, a partir de entrevistas; narrativas visuais (desenho); e sessões reflexivas. Os resultados demonstram que ocorreu uma ressignificação no olhar dos participantes por meio do trabalho em colaboração crítica durante o processo.

Palavras-chave: Migrantes Bolivianos, PCCol, Teoria Histórico-Cultural e Social.
Um Estudo Sobre as Contribuições do Software Nvivo Numa Abordagem Qualitativa de Pesquisa
Authors: Sá Cristiane Freire de
Published: October 2023

Este artigo objetiva apresentar as possíveis contribuições do software NVivo para as pesquisas que façam uso de metodologias e abordagens qualitativas, como as que são desenvolvidas e realizadas no âmbito da Linguística Aplicada . Visando alcançar este objetivo, optou-se pela análise dos processos metodológicos utilizados numa tese de doutorado em que o software NVivo foi utilizado para auxiliar nos processos de organização e interpretação dos textos que foram gerados na pesquisa. O estudo apresentado neste trabalho foi realizado por meio de uma análise do capítulo de metodologia da tese de Sá (2022) escolhida como objeto de estudo, visando identificar e contrastar de que modo a utilização do software NVivo contribuiu para o desenvolvimento da pesquisa. A análise realizada possibilitou identificar que as ferramentas de organização do software NVivo possibilitam que o pesquisador possa realizar processos de identificação, seleção, conexão e interpretação de informações, relacionando-as e organizando-as com abordagens qualitativas interpretativas como a Abordagem Hermenêutico-Fenomenológica Complexa proposta por Freire (2010, 2012, 2017). Também foi possível identificar que o NVivo pode ser bastante útil para diferentes abordagens qualitativas, desde que o pesquisador as conheça com certo nível de profundidade para que não utilize os recursos tecnológicos do software de maneira superficial ou equivocada. Além destas possibilidades, este estudo também permitiu descobrir algumas limitações de utilização do software que podem ser resolvidas com as novas versões e com atualizações, a depender das metodologias e abordagens qualitativas escolhidas.

Palavras-chave: Pesquisa Qualitativa, Software, NVivo, Linguística Aplicada.
PADRÕES DIFERENCIADOS DE RECUO DA LINHA DE COSTA E SUA CORRELAÇÃO COM PROCESSOS EROSIVOS E AS ÁREAS DE RISCO À EROSÃO COSTEIRA NO ESTADO DO PARÁ
Authors: Teixeira Sheila Gatinho , BANDEIRA ÍRIS CELESTE DO NASCIMENTO
Published: October 2023

A região costeira do Estado do Pará possui uma rede
complexa de estuários, submetida à macromarés, mesomarés e a altas correntes de marés, que associadas
a ondas, alto índice pluviométrico e a uma geologia
diversificada, composta por materiais pouco consolidados proporcionam processos erosivos costeiros diferenciados. Estas áreas suscetíveis a processos erosivos
foram ocupadas sem planejamento territorial, levando
ao surgimento de áreas de risco à erosão. Portanto, este
trabalho tem como objetivo caracterizar os agentes e
processos erosivos, associando com a forma de ocupação dos setores de risco, a fim de diferenciar padrões
de recuo da linha de costa. Para isso foi realizada revisão bibliográfica, análise temporal de dois mosaicos de
imagens Landsat (1988 e 2019), para verificar a dinâmica costeira em escala regional, e avaliação estatística e
a forma de ocupação de 54 setores de risco alto e muito
alto à erosão costeira mapeados pelo Serviço Geológico do Brasil, no período de 2012 a 2019, em 12 municípios do Estado do Pará. Foi possível identificar dois
padrões de recuo de linhas de costa, que envolvem diferentes processos. Quando estes setores ocorrem nas
margens dos estuários (região interna), estão associados à ocupação do topo das falésias, sendo submetidos
aos processos de deslizamentos, solapamentos e erosão
laminar, bem como, a influência do despejo de águas
servidas na face da falésia. Quando estes ocorrem nas
porções externas dos estuários, estão associados ao déficit sedimentar nas praias arenosas e estão relacionados a processos como: retenção dos sedimentos oriundos da plataforma pelos bancos submersos localizados
na foz dos estuários, ocupação desordenada da faixa
dinâmica das praias e migração dos canais de maré em
direção ao continente. Essa caracterização pode ser utilizada como subsídio pelos órgãos competentes no gerenciamento costeiro e na mitigação dos eventos, que
devem levar em consideração as características físicas
e oceanográficas locais.
SUSCETIBILIDADE GEOLÓGICA DAS BARRAGENS DE MINERAÇÃO NO ESTADO DE MINAS GERAIS: UM PANORAMA PRELIMINAR A PARTIR DE MODELAGEM ESTATÍSTICA E MORFOMÉTRICA
Authors: NORONHA FABIO DE LIMA
Published: October 2023

O risco de acidentes e desastres relacionados a falhas
no projeto, construção, operação e manutenção de barragens constituem tema de estudo bastante recorrente.
Porém, poucos são os trabalhos que relacionam a possibilidade de falhas em barragens com processos geológicos que ocorrem no ambiente que as cercam. Paradoxalmente, não são raros os registros na literatura
em que eventos pluviométricos extremos, enxurradas
e movimentos de massa no entorno das estruturas foram deflagradores ou contribuíram para a sua ruptura. A presente pesquisa busca contribuir com o tema
da segurança de barragens, a partir da identificação
de cenários de suscetibilidade natural à deflagração
de deslizamentos, corridas e enxurradas nos terrenos
do entorno das barragens de mineração no estado de
Minas Gerais. Para tal, executou-se uma modelagem
estatística e morfométrica da suscetibilidade natural a
movimentos de massa e processos hidrológicos, através do emprego de ferramentas de geoprocessamento
em variáveis derivadas de modelo digital de elevação
(MDE) e fotointerpretação, tais como lineamentos geológicos, declividade e curvatura do terreno. O produto
final é a construção de um sistema de informação geográfica (SIG) com o zoneamento da suscetibilidade a
movimentos de massa de todas as barragens de mineração do estado de Minas Gerais, oriundas do cadastro
oficial da Agência Nacional de Mineração (ANM). O
zoneamento permitiu o cálculo de estatísticas para o
universo de barragens estudado, com base na suscetibilidade geológica de seus sítios de locação. Os resultados demonstram que 38% dos terrenos no entorno das barragens possuem média a alta suscetibilidade a deflagração de deslizamentos, e que 30% das estruturas
estão locadas em bacias de drenagem com alta suscetibilidade aos processos de enxurradas ou de corridas
de massa.
Qualidade de dados em projetos de data warehouse
Authors:   , SACRAMENTO JAISON DA SILVA
Published: October 2023

O conhecimento para tomar uma decisão existe após a existência de uma informação
que o sustente, e essa, a informação depende da existência de dados que a qualifique.
A qualidade de dados, que é sinônimo de qualidade da informação, que pode ser
exemplificada em um processo para tomar uma decisão de redução custos, ao
analisar os relatórios de Business Intelligence armazenados nos sistemas de banco
de dados construídos para Data Warehouse, constata-se que estes relatórios
possuem informações diferentes dos sistemas de contabilidade da empresa. O
conhecimento para tomar a decisão exemplificada, somente existe após a existência
de uma informação correta, e essa, a informação depende da existência de dados que
sejam qualificados. Nesse contexto as empresas estão preocupando-se e investindo
cada vez mais em processos e ferramentas que proveem qualidade das informações
que podem ser definidas como um conjunto de fragmentos, que foram extraídos de
diversas fontes e passaram por um processo seguindo padrões de governança de
dados, que foram validadas em seus atributos de credibilidade, acessibilidade,
facilidade de manipulação, reputação, disponibilidade, pontualidade, além de
segurança e confiabilidade. Partindo dessa realidade este trabalho apresenta
metodologias e processos para uso de ferramentas com enfoque na qualidade de
dados.
Manual de tópicos em Ginecologia da Sopigo
Authors: Vieira Sabas Carlos , Valentim Jussara Maria , Damásio Lia Cruz Vaz da Costa , Lopes One Maria Ribeiro , Silva Maria Clara Amorim
Published: October 2023

As doenças ginecológicas representam problemas importantes em saúde
pública, podendo levar a uma perda importante da qualidade de vida
e da sobrevida das mulheres. Compreender as principais doenças ginecológicas
tanto pelo médico da atenção básica como pelo especialista ajuda a mitigar
os desfechos desfavoráveis. O objetivo da presente obra é trazer uma atualização dos
principais tópicos em Ginecologia com foco na parte prática, benefi ciando o especialista,
o estudante de Medicina e os médicos ginecológicos.
As dificuldades na leitura e escrita no ensino fundamental: numa escola municipal de Cajazeiras-PB
Authors: Lima Maria Loureto de , França Rosa Maria Elias de , Lima Antonia Angela de
Published: October 2023

Pode-se dizer que o processo de leitura e escrita não se trata apenas de um produto final do processo escolar, mas sim, uma importante conquista para o desenvolvimento de uma sociedade. O aluno ao aprender a ler e escrever começa a desenvolver melhor a linguagem tornando-se mais comunicativo, fazendo parte de um grupo social com vida e histórias individuais. Todo esse processo facilita na construção da aprendizagem do aluno. Segundo Alves (2007), a aprendizagem pode ser definida como uma modificação do comportamento do indivíduo em função da experiência. E pode ser caracterizada pelo estilo sistemático e intencional e pela organização das atividades que a desencadeiam, atividades que se implantam em um quadro de finalidades e exigências determinadas pela instituição escolar. Todo o processo de aprendizagem manifesta-se como uma maneira como os indivíduos adquirem novos conhecimentos, desenvolvem competências e muda o comportamento, isto se trata de um processo bastante complexo que, dificilmente, se pode ser explicado apenas através de recortes do todo.
Non-variant phenomena in heterogeneous systems. New type of solubility diagrams points
Authors: Nikolay A Charykov , Konstantin N Semenov , Victor A Keskinov , Alexey V Rumyantsev , Natalia A Kulenova , Marina V Charykova , Dmitriy I Subbotin
Published: October 2023

The article gives a general classification of non-invariant points in phase equilibrium diagrams of all possible types. The complete topological isomorphism of the diagrams of fusibility, solubility, and liquid-vapor equilibria in various sets of variables is demonstrated. The stability of mono-variant equilibria near the non-variant points is investigated. Recurrent formulas for calculating the number of topological elements of phase diagrams are given. A previously undescribed type of non-invariant points and phase processes in the solubility diagrams is described and characterized. The last ones have no topological analogs in other types of diagrams. Thus, we have carried out, as far as is available to the authors, a complete classification of invariant points and invariant processes in phase equilibrium diagrams of an arbitrary type and with an arbitrary number of components.
A structural model of student continuance intentions in ChatGPT adoption
Authors: Saxena Anoop , Doleck Tenzin
Published: October 2023

ChatGPT has experienced unprecedented acceptance and use, capturing popular and academic attention. With this growth in use comes the need to focus on the determinants of ChatGPT use as the success of a technology or service depends largely on users’ continuance intentions. Modeling what influences students’ intention to continue using ChatGPT is important to better understand how students search for information and their decision-making process. Using a sample of 106 students, we test a structural model developed using the unified extended-confirmation model. The research model included the following elements: subjective norm, perceived usefulness of continued use, disconfirmation of their expectations from prior use, satisfaction with prior use, and continuance intention. The findings demonstrate support for the proposed research model as the research model explains 60.5% of the variance in continuance intention. In terms of the direct influence on continuance intention, the role of perceived usefulness and satisfaction were documented. The present study has the potential to serve as a starting point for improving our understanding of antecedents of continuance intentions in the context of ChatGPT.
What we learned in the short term from the 2023 Kahramanmaraş Earthquakes in terms of Orthopedic Trauma: A brief literature review.
Authors: ASLAN Ahmet , ZENGİN Çağatay , BÜYÜKCERAN İsmail
Published: October 2023

In this article, we have attempted to briefly review retrospective research articles related to Orthopedics and Traumatology in the context of the earthquakes centered in Kahramanmaraş to date.
A descriptive cross sectional study of job satisfaction among pharmacists in a clinical setting
Authors: Suleiyol Charity Abatur  , Chiedozie Nickson Ugwoke  , Ter Basil Anweh  , Tony Felix Ogbeh  , Terwase Simon Amgah  , Daniel Friday Onuh  , Aungwa David Awua
Published: October 2023

Background: Job satisfaction has been linked to improved job performance. Pharmacists as key healthcare providers with the ultimate duty of improving and maintaining the quality of life through the responsible provision of drug therapy, are expected to be highly productive. Low performance by Pharmacists can result to loss of lives especially through undetected actual and potential drug therapy problems which have been documented to be associated with high mortality and high rate of hospital admissions. Job satisfaction is the feeling of fulfilment that employees derive from their job which has a significant deal on their productivity. Assessing Pharmacists’ job satisfaction is therefore very paramount. Objective: This study accessed job satisfaction among Pharmacists working in a tertiary hospital and identified factors affecting job satisfaction among the study population Method: The study was a descriptive cross sectional study that employed the use of questionnaires as a research instrument for data collection with 30 participants completing the questionnaires. Simple percentages were used to analyse demographic characteristics and level of satisfaction. Relationship between variables was tested using chi square. Level of significance was measured at 95% confidence interval (p=0.05) Result: There was male participants’ preponderance (76.7%). Majority of the participants had practice years between 11-20 years (56.7%). 63.3% had Masters Degrees, 93.3% were Christians and 80% married. Level of job satisfaction was 33.3% among the participants. Hospital culture (76.7%), work environment (60%), reward system (60%) and remuneration (53.3%) were found to be factors recorded with the highest level of dissatisfaction. The Pharmacists were some-what satisfied with how their contribution were valued and the value placed on them by the organisation (53.3% each). However, satisfaction with their position was moderate (40.0%). Conclusion: Hospital pharmacists are important healthcare professionals that play critical roles in determining the effectiveness, efficiency, and sustainability of health care systems vial the delivery of pharmaceutical services. Showing concerns for Pharmacists welfare is an important factor to enhancing their job satisfaction with resultant improvement in the quality healthcare delivery. It is paramount that Government of Nigeria upgrades the remuneration of Pharmacists and provides conducive work environment as these would enhance productivity and effective pharmaceutical delivery to our teeming patient population.
Tiftiğin Ankara’dan Silinişi (1880-1920)
Authors: KAYNAR İhsan Seddar
Published: October 2023

Sanayi Devrimi öncesinde tekstil sektörünün en önemli hammaddelerinde biri olan tiftiğin üretim alanı Osmanlı İmparatorluğunun toprakları içinde yer alan Ankara Vilayetidir. Bir hammadde olarak tiftiğin, kırsalda hayvan yetiştiricileri ile başlayan iktisadi süreci, ipe dönüştürülmesi, iplerin renklendirilmesi, kumaşa dönüştürülmesi ve tezgahlarda gündelik kullanım malzemelerine dönüştürülmesini içeren uzun aşamaları barındırmaktadır.

Bir liman şehri olmamasına rağmen Ankara, 19.yy’ın sonuna kadar tiftik ürünlerinin ticaret merkezi olmuş, bu merkezde hakim ürün tiftik keçisi yetiştiriciliği olmuştur. İstanbul-Ankara Demiryolunun 1893 yılında faaliyete başlaması ile eş zamanlı olarak, bölgede hububat üretimi artmaya başlamış ve 1896 yılında hububat ihracı tiftik ihracını geçmiştir. 20.yy’ın ilk çeyreğinde Ankara çevresinde hayvancılıktan hububat üretimine hızlı bir geçiş yaşanmış; tiftik keçisi yetiştiriciliği önemini yitirmiştir. Demiryolunun gelişi, tiftiğin dış talebinden bağımsız olarak Anadolu’dan silinmesinde önemli bir aşamadır. Zamanla tiftik keçisi tür özelliklerine kaybetmeye başlamıştır. Birinci Dünya Savaşının başlaması ve Osmanlının dağılma sürecinin son aşaması olan Milli Mücadelenin en önemli savaşlarının 1919-1922 yılları arasında Ankara ve çevresinde gerçekleşmesi, tiftik açısından geri gidiş sürecinin son aşaması olmuştur.

Tiftik Türkiye’de ve Ankara’da silinirken, dünyada üretim alanları genişlemeye başlamıştır. Bu çalışmada Anadolu’nun kendi içsel dinamikleri ile başlayan tiftiğin gerileme süreci incelenecek ve tarımsal değişimin yereldeki dinamikleri ile uluslararası etkenlerin rolleri karşılaştırılacaktır. Önemli bir ihraç malı olarak tiftiğin Anadolu’da geçirdiği 40 yıllık dönüşüm İstanbul’daki Osmanlı Arşivinden ve Londra’daki İngiliz Arşivlerinden elde edilecek arşiv kaynakları ile açığa çıkarılmaya çalışılacaktır.
PENDAMPINGAN LITERASI GERAKAN MENUMBUHKAN MINAT BACA BAGI ANAK–ANAK LOKR DI DUSUN WAIPUTIH
Authors: Handayani Nanik , Rambe Nana Ronawan
Published: October 2023

Children's reading ability is the basis for mastering various fields. PISA data 2018 shows that the literacy and numeracy abilities of Indonesian children tend to be stagnant and are ranked second from the bottom. To develop children's literacy and numeracy skills, appropriate strategies are needed so that children are interested and trained to develop reading, writing and understanding the information around them. This PKM aims to provide assistance as an effort to strengthen children's literacy. The method in this PKM is by applying the LOKR steps namely Literacy, Orientation, Collaboration and Reflection. The result of this activity is that at the literacy stage the child still has difficulty answering questions from the story that has been read, it is necessary to do repetition and reinforcement at the orientation stage students have started to find answers, the collaboration stage is carried out to stimulate children who are still considered low to understand the meaning of reading, at In the reflection stage, the child can find answers to questions. The conclusion of this activity is that children's literacy skills tend to be at the level of needing intervention and basic. Furthermore, habituation is needed so that children like to read and understand what they read. It was proven that at the third meeting in this PKM activity the children had increased their ability to read and understand the contents of their reading.
Meningkatkan Hasil Belajar Lempar Lembing Melalui Pemanfaatan Media Audio Visual Pada Siswa Kelas XII SMA Negeri 3 Maluku Tenggara
Authors: Betaubun Chrisdi Yanto , Tahapary Jhoni Melvin
Published: October 2023

This research is Classroom Action Research (PTK). This research was carried out in two cycles, each cycle consisting of planning, implementing actions, observing and reflecting. The research subject were class XII SMA Negeri 3 Southeast Maluku, totaling 24 students. The data sources are teachers, students and researchers. Data collection techniques using observation, tests, and documentation or archives. Based on the results of the analysis, a significant increase was obtain from pre-cycle to cycle I and from cycle I to cycle II. Of pre-cycle total of 24 students, only 14 students completed and 10 students did not or a percentage 75% and 25% students did not complete. Then the cycle I show an increase, 14 students or 75% were complete category and the remaining 10 students or 25% were in the complete category. In cycle II the increase in student learning outcome was 100% or 24 students complete category. conclusion that the use of visual audio media can be used to improve javelin throw learning outcome for class XII SMA Negeri 3 Southeast Maluku.
Overseas and home students’ perspectives towards the implementation of portfolio-based timed-writing technique in composition class
Authors: Syafei Muh , Fajardo Ana Cecillia , Rusiana Rusiana , Hilal Achmad , Montales Cherry Love B
Published: October 2023

This inquiry addressed students’ perspectives towards the implementation of the Portfolio-Based Timed-Writing Technique (PBTHT) under an international transfer credit (ICT) program at Universitas Muria Kudus. It is to answer the following questions: (1) What are the overseas students’ perspectives towards the PBTHT implementation? (2) How do their perspectives compare to their home counterparts? Using narrative analysis, this study qualitatively revealed that PBTHT is a new technique for overseas students. Their perspectives show their composition strengths cover the use of proper grammar, spelling, and mutually supportive essay elements. Meanwhile, their weaknesses include the content and mechanics. Overseas and home students expressed different perspectives due to different experiences, abilities, and teaching processes in their respective countries. Both groups acknowledged that the PBTHT implementation help them with the improvement of their writing skills.
Translation shift and the equivalence in children’s novel “The House at Pooh Corner”
Authors: Wulansari Atsani , Arvianti Gilang Fadhilia , Wulanjani Arum Nisma , Annafi' Salma
Published: October 2023

Translating literary works such as novels, poetry, short stories, and dramas is widely conducted in Indonesia to introduce literature to the Indonesian people. In translating literary works, the transfer of messages from the source language must be appropriate and flexible in the target language because literary works have their aesthetic function, so translators need to have a broad knowledge of the qualified sociocultural background. Translators do not only translate meaning but also translate the values of literary works such as moral value and cultural value. The role of translators is to find out the equivalence in the target language and use their creativity to solve the non-equivalence in the target text. Equivalence is the main concept to achieve translation quality. This study aims to find the type of translation shift that occurred in the translated version of the children’s book entitled ‘The House at Pooh Corner’ based on Catford theory and to analyse the equivalence of translation according to Popovic. This research is qualitative research which applies content analysis. The data was collected through documentation. It is found that there are level shifts and category shifts in the translated version of The House at Pooh Corner. In addition, the types of equivalence found in this research are paradigmatic equivalence, stylistic equivalence, and textual equivalence. This research is expected to be used as the material for students to understand more about shifts and equivalence in literary translation
Immunological disorders in patients with mammary gland pathology in infertility associated with anovulation
Authors: Gladenko S.Е. , Netskar I.P. , Susidko O.M. , Kovalishin O.A.
Published: October 2023

The objective: to study the state of the immune system in women with pathology of the mammary glands and infertility, and on the background of menstrual cycle disorders.Materials and methods. The research was performed in two stages. The first (1) stage included examination of women with infertility associated with anovulation who had breast pathology. These patients were divided into three groups: 1.1 group – 44 patients with diffuse fibrocystic breast disease (FBD), 1.2 group – 4 patients with fibroadenoma of the mammary glands, 1.3 group (control one) – 37 patients without pathological changes in the mammary glands.During the second (2) stage of the study, 110 women were examined: 2.1 group – 52 patients with regular menstruations and luteal phase insufficiency (LPI) and 2.2 group – 58 patients with anovulatory cycles.During two research stages, the immune status (CD3, CD4, CD8, immunoregulatory index (CD4/CD8), CD72, CD16, circulating immune complexes) and cytokine profile (IL-1, IL-2, IL-6, TNF-α, INF) in venous blood were determined. Differences were considered statistically significant at p<0.05.Results. A significant increase in the CD8 index was found in the group of patients with normal mammary glands (34.7±6.9 pg/ml; p<0.05) and with a diffuse form of FBD (35.13±6.9 pg/ml; p<0.05) versus its normal level in the group of patients with fibroadenoma (26.5±15.9 pg/ml; p>0.05).During the analysis of the CD16 level, it was determined its significantly increased to 18.8±3.1 pg/ml (р<0.05) in patients with LPI and regular menstrual cycle and to 26.3±4.8 pg/ml (р< 0.05) – in patients with anovulation without LPI, the difference between the groups was significant. The level of CD16 was significantly higher in anovulatory menstrual cycle disorder without LPI compared to patients with menstrual cycle disorder and LPI.The concentration of TNF-α in patients with a regular menstrual cycle (998.1±166.3 pg/ml; p<0.05) and with an anovulatory cycle without LPI (1029.3±187.1 pg/ml; p<0.05) was significantly higher compared to normal values (778.5±64.0 pg/ml). The level of IL-2 was significantly lower than normal indices. Thus, in the group of women with LPI, this indicator was 17.13±2.85 pg/ml (р<0.05), and by anovulation without LPI – 16.84±3.07 pg/ml (р<0.05) versus normal parameter 22.29±0.81 pg/ml.Conclusions. In patients with diseases of the mammary glands and infertility associated with anovulation without LPI, a significant decrease in the activity of T2-helpers (IL-2) and an increase in the activity of T1-helpers (TNF-α) were determined in cases of anovulation without LPI compared with cases of luteal phase insufficiency.
Biocenosis of the vagina and modern approaches to the correction of vaginal dysbiosis (Literature review)
Authors: Gorbunova O.V. , Zarichanska Kh.V. , Shcherbinska O.S. , Netskar I.P. , Iarova I.V.
Published: October 2023

In the modern world it is important to understand the interaction of macro- and microorganisms in normal conditions and during illness. It is the biotope of the vagina that plays an extremely important role in a woman’s organism and it reflects the general state of woman’s health. Urogenital endogenous microflora is not static, it is a constantly changing macropopulation. In this population the number of specific types of microorganisms fluctuates within the limits of changes in the conditions of their environment. The microflora of the vagina changes during different periods of a woman’s life, namely during perinatal, late neonatal, prepubertal, pubertal, reproductive and postmenopausal periods, as well as the menstrual cycle, daily and hourly. The ability of commensal microorganisms to protect the region from the invasion of their own microflora from other cavities and the microflora of the sexual partner is unique. Considering the general global trend towards the increase in prevalence, virulence and resistance of microorganisms to traditional methods of antiseptic therapy, as well as the appearance of new types of microorganisms, a steady trend towards an increase in infectious diseases, including sexually transmitted infections, is determined. Dysbiosis is considered qualitative and quantitative violations of the corresponding biotope of the normal flora. According to official statistics, the prevalence of bacterial vaginosis is 10-35% among all patients with pathological vaginal discharge. The variability of the vaginal microbiome is widely studied in the world and depends on many factors, namely the hormonal background of a woman’s organism, her diet, the characteristics of urination and defecation, menstruation, hygienic procedures and infections. One of the key links in the pathogenesis of vaginal infectious diseases is the ability of bacteria to form biofilms, which are microbial associations. Infections caused by film-forming strains of pathogenic and opportunistic microorganisms are characterized by an atypical course, insufficient effectiveness of antibiotic therapy, and often transition to a chronic form or carriage. Therefore, understanding the mechanisms of formation, structure and regulation of vital activities of biofilms helps in solving problems related to human health. The World Health Organization recommends evaluating the vaginal microbiome according to the Hay – Ison criteria. Determining the pH of vaginal secretions also helps to establish the type of vaginal dysbiosis. Clinical therapy includes two main stages of treatment: antiseptic measures and restoration of one’s own vaginal microbiome. Often, these two stages of therapy are carried out simultaneously. Correcting the pH of the vaginal secretion is also important.
Theoretical and Methodological Basis of Research State Policy Regarding System Modernization Provision of Primary Medical Aid
Authors: Shkilnyak Mykhailo , Derpak Kateryna , Derpak Yurii
Published: October 2023

A study of the historical aspects of the state policy about the modernization of the system of providing primary medical care in Ukraine was conducted. The sources of information were the published scientific works of Ukrainian and foreign researchers, in particular, the search and bibliographic method was used to systematize scientific works on the research topic; the comparative legal method was used during the analysis of general and special legal acts; the methods of analysis and synthesis, classification and systematization, generalization and analogy were used to study the dynamics of the development of the legal framework that regulates the issue of modernization of the primary medical care system; the method of generalization and the prognostic method were used in the process of formulating conclusions, recommendations and propositions.
The current state of the policy regarding the preservation of the health of the nation has a number of problems, as there are prerequisites for a real threat to the health of the population. As a result, the country is experiencing steady depopulation, mainly due to the high mortality rate of people of working age.
In the first decades after the declaration of independence of our state, health care reforms were aimed at preserving the existing model of the health care system and providing the population with medical care, while maintaining the minimum level of social guarantees. This did not help to prevent many diseases before they required complex, expensive and not always successful treatment. The question arose of reforming the ineffective health care system, which is unable to provide satisfactory medical services and suffers from corruption.
In accordance with the main priorities of reforming the health care sector, the implementation of the process of modernization of the health care system was started, which is based on the main principles, namely: the availability and quality of medical care for the population within the framework of the integrated health care system, ensuring real access of the population to quality medical services, transfer of the industry to a qualitatively new level and introduction of effective medical insurance.
Chronic Obstructive Pulmonary Disease and Sleep Apnea Syndrome – a Multidisciplinary Problem of Clinical Medicine
Authors: Chaplynska Nataliia , Rudnyk Viktoriia , Havrysh Taras , Symchych Khrystyna , Skrypnyk Liubov
Published: October 2023

Obstructive sleep apnea syndrome (OSAS) and chronic obstructive pulmonary disease (COPD) are more common pathologies in clinical practice, which are accompanied very often by cardiovascular comorbidity.
The objective: to analyze the clinical features of chronic obstructive pulmonary disease course in combination with the risk of sleep apnea syndrome.
Materials and methods. 47 patients with COPD III degree of bronchial obstruction, group E participated in the study: 9 (19.1%) women and 38 (80.9%) men. The study participants were divided into two groups: I group (COPD) – 32 persons, II group (COPD + apnea syndrome) – 15 individuals.
Clinical, spirographic laboratory, X-ray, ultrasound, and electrocardiographic examinations were performed to the patients, the STOP-Bang questionnaire was used to determine the risk of sleep apnea syndrome development, and the influence of bronchial obstruction on the daytime sleepiness (Epworth scale) and depression (Beck questionnaire) was studied.
Results. The analysis of the results of the study presented that among the examined patients with COPD 32 (68.1%) subjects were identified with a high risk of sleep apnea syndrome. In this cohort of patients there were signs of daytime sleepiness according to the Epworth scale, and according to the Beck questionnaire they scored more than 10 points, that is, a mild level of depression of situational or neurotic origin was found.
It was found that among patients with COPD in combination with the risk of night apnea (II group), coronary heart disease was diagnosed in 24 (75%) cases, arterial hypertension – in 22 (68.8%) cases, diabetes – in 15 (46.9%). At the same time, the prevalence of these nosologies in patients with COPD without the risk of night apnea was significantly (p<0.05) lower. The Charlson comorbidity index in patients with COPD and risk of apnea was within 3–4 points, 10-year survival was within 77–53%.
Conclusions. The high risk of apnea syndrome according to the results of the screening questionnaire, excessive daytime sleepiness, and depressive states in patients with COPD should prompt primary care physicians to refer such patients to a comprehensive polysomnography examination to confirm OSAS. After all, COPD, OSAS and cardiovascular comorbidity are characterized by a more unfavorable clinical course and prognosis than each of these diseases separately.