bluuebunny/crossref_metadata_2025 huggingface dataset:
Gothic motifs in A. Conan Doyle’s “The Brown Hand” and V. Fedorov’s “The Moonlight Sonata”
Authors:   Ammosov North-Eastern Federal University, Burtseva Marina A. , Burtsev Anatoly A.
Published: November 2022

The article presents a comparative study of the stories “The Brown Hand” by Arthur Conan Doyle and “The Moonlight Sonata” by Vladimir Fedorov in terms of the Gothic aesthetics. There are significant typological similarities, in particular, in developing the redemption of guilt plot with consequent events such as the main character’s arrival at his relative’s house, an encounter with supernatural phenomena, a search for assistance and a final redemption from the curse. The stories have similar systems of characters: an elderly family member, his young relative with rational views, a restless ghost, and a minor character, an innocent victim of the ominous events. In the both stories, the Gothic chronotope is concentrated around a remote place, where events happen mostly at night. As significant are the parallels in the key motifs: the motifs of estrangement and fear, creating a peculiarly gloomy atmosphere (appearance of ghosts); the plot-building motif of a fatal secret and supernatural invasion, which convey the motifs of prosecution and guilt; and the double-vector motif of redemption.
Dynamics of semantics and pragmatics of conflictogenic texts in Russian mass media in 2020–2021
Authors:   Lomonosov Moscow State University, Denisova Galina V. , Smirnova Olga V. , Antipova Alina S.
Published: November 2022

The increase of digitalized texts available to the public on an everyday basis in the Internet have created media-focused space which main characteristic is constant content change. Therefore, each specific social sphere may be traced throughout content provided in media sources internationally and locally. Our study is based on revealing semantic features of conflict terminology that is understood as the number of related-to-conflict words used together in socio-cultural media discourse. The purpose of this study was to reveal contextual short-term meaning changes for conflict terminology in leading federal Russian newspapers “Komsomolskaya Pravda”, “Rossiyskaya Gazeta” and “Kommersant”, as well as the online media sources such as Lenta.Ru and Gazeta.Ru. The corpus of 24 697 texts was formed based on the occurrence of conflict-related topics as the object of this research. The research period was January-December 2020/21.
Causes and effects of linguistic creativity in intercultural communication
Authors:   Far Eastern Federal University, Nikolaeva Olga V.
Published: November 2022

The research is devoted to the problems of linguistic creativity in intercultural communication. The features of modern intercultural communication in new digital media are considered: social networks, electronic mass media, and the Internet-communication. The causes of intercultural communicative failures on the topic of international relations are revealed and the role of invective linguistic creativity in the emergence and development of intercultural conflict is established. It is determined that the perception of linguistic innovations in the context of intercultural communication is determined not only by linguistic, but also by cultural and pragmatic factors, and in the modern world it is increasingly burdened with negative evaluation which depends on political and ideological aspects. In the context of international political and economic confrontation, the relevance and aesthetics of linguistic or discursive innovation often becomes one-sided and is interpreted only from the point of view of the addresser. In the examples considered, linguistic creativity in the statements of heads of state in social networks violates the norms of speech behavior, the language standard, causes difficulty in perception, leads to misunderstanding and rejection by interlocutors representing different cultures and languages, and is often invective. In order to avoid communication failures, the relevance and aesthetics of non-standard language forms should be evaluated not only from the point of view of the addresser, but also the recipient of the message, otherwise, unintentionally or intentionally, there is a threat of intercultural communication failure.
Health Promotion Strategy to Increase Cadre Knowledge about Stunting in the Work Area of the Puskesmas Krembangan Selatan
Authors: Yunara Yulia , Lestari Wahyu Agustin Eka , Indarwati Retno , Mufida Laila , Rahmadi Chandra , Hidayati Wa Ode Dewi , Rohman Rizal Fatkhur
Published: November 2022

Background: Stunting is a serious problem in Indonesia that has not been resolved, one of which is in the work area of the Krembangan Health Center where there are 25 toddlers who have stunting problems, one of the causes is the lack of knowledge of cadres about stunting problems in toddlers. So that an action is needed to increase public knowledge through health promotion activities. This health promotion is carried out by implementing community empowerment strategies through cadres. Objective: This community service activity aims to determine the effect of providing health promotion on stunting to health cadres. Methods: The data collection method in this study used pre-test and post-test questionnaires. The counseling method used is lecture, discussion and audiovisual where this audiovisual is in the form of a video containing material on stunting prevention. The number of respondents in this study were 20 people. Results: The results of the assessment showed that there was a difference in scores on the pre-test and post-test, namely the average score on the pretest was 8.2, while the score on the posttest showed that the average respondent was 9.55, there was an increase in value by 80%. Conclusion: Based on the counseling that has been carried out, it can be concluded that the knowledge and awareness of cadres about stunting has increased. This shows that health education is very important in overcoming health problems, especially the prevention of stunting. It is hoped that outreach activities on stunting prevention can be carried out sustainably with broader methods and targets such as creating social media groups with cadres as a forum to provide new information about stunting and as a medium for discussion.
Impact of barrel toasting on the cognac eau-de-vie sensory profile
Authors: Gadrat Mathilde , Lavergne Joël , Emo Catherine , Teissedre Pierre-Louis , Chira Kleopatra
Published: November 2022

During barrel production, the oak undergoes several processing stages that contribute to wine and brandy flavours. The toasting step is considered to have the most important influence on oak wood chemical composition as it causes the thermodegradation of some oak wood components. However, the effect of toasting on distilled spirit quality has not been thoroughly studied. Thus, the objective of this study was to determine the impact of barrel toasting on the cognac eau-de-vie sensory profile.
Pertanggungjawaban Keuangan Daerah Dalam Rangka Kunjungan Kerja Dewan Perwakilan Rakyat Daerah
Authors: Difaul Khaq Mukhamad Iqom
Published: November 2022

The purpose of the research is to examine the mechanism for implementing the use of regional finances in the framework of the working visit of the Regional House of Representatives (DPRD) of Pekalongan City in 2014 and the accountability of the implementation of the use of regional finances in the framework of the working visit of the DPRD of Pekalongan City according to Law Number 23 of 2014 on Regional Government. This research uses normative research methods supported by empirical studies. The results of the study conclude that first, the mechanism for implementing the use of regional finance in the context of a working visit to the DPRD of Pekalongan City is not based on the provisions according to Law Number 23 of 2014. The inaccuracy in the implementation is evidenced by the report on the results of the examination of the Central Java BPK RI LKPD 2016 Number 55C/LHP. /BPK/XVIII.SMG/05/2017 dated May 22, 2017. Second, the accountability for the implementation of the use of regional finances in the framework of the working visit of the DPRD of Pekalongan City is not based on Law Number 23 of 2014 on Regional Government. Members of the DPRD of Pekalongan City as the executor of the activity did not fully make the accountability document in accordance with the actual reality. The DPRD Secretary, PPTK, and the Expenditure Treasurer at the DPRD Secretariat are not careful in controlling and verifying the evidence of accountability for the Work Visit activities of Leaders and DPRD members outside the region.
Precise Spiking Motifs in Neurobiological and Neuromorphic Data
Authors: Grimaldi Antoine , Gruel Amélie , Besnainou Camille , Martinet Jean , Perrinet Laurent Udo
Published: November 2022

Why do neurons communicate through spikes? By definition, spikes are all-or-none neural events which occur at continuous times. In other words, spikes are on one side binary, existing or not without further details, and on the other can occur at any asynchronous time, without the need for a centralized clock. This stands in stark contrast to the analog representation of values and the discretized timing classically used in digital processing and at the base of modern-day neural networks. As neural systems almost systematically use this so-called event-based representation in the living world, a better understanding of this phenomenon remains a fundamental challenge in neurobiology in order to better interpret the profusion of recorded data. With the growing need for intelligent embedded systems, it also emerges as a new computing paradigm to enable the efficient operation of a new class of sensors and event-based computers, called neuromorphic, which could enable significant gains in computation time and energy consumption — a major societal issue in the era of the digital economy and global warming. In this review paper, we provide evidence from biology, theory and engineering that the precise timing of spikes plays a crucial role in our understanding of the efficiency of neural networks.
Effectiveness of a Woodworking Program on Psychosocial Health among Older Adults with Cognitive Impairment
Authors: Lee Hyun-Joo , Ban Si-Woo , Chung Ha-Yun , Jeon Myoung-Ok , Kim Kye-Yean , Kim Ja-Eun , Lim Ki-Woung , Choi Chang-Ick , Choi Don-ha , Hwang Ui-Do , Shin Won-Chul , Shin Hye-Ri , Kim Young-Sun
Published: November 2022

ackground: This study aimed to examine the effects of a woodworking program on psychosocial health in older adults who had mild cognitive impairment (MCI) or mild dementia (MD) in Korea. Setting: The study was carried out in a dementia center in Seoul in Korea. Population: A total of 61 participants who had MCI or MD were allocated into two groups: the experimental group (EG, n = 35) and the control group (CG, n = 26). Methods: This study was carried out using a nonequivalent control group pre-test–post-test design. The EG participated in the woodworking program a total of 10 times for 120 min per session twice a week for 5 weeks, and the CG did not participate in the woodworking program. Both groups completed the same survey before and after the intervention. In the survey, demographic characteristics, psychological health (life satisfaction, depression, self-efficacy, and resilience), and social health (social isolation and social support) were measured. Results: In the within-group comparison, there was no significant difference between any factors of the CG before and after the intervention. In contrast, the EG had a significant improvement before and after the woodworking program. Participants in the EG with MCI and MD significantly improved their social support (p < 0.05). Psychological factors (life satisfaction, depression, and self-efficacy) were positively changed, although not significantly. Conclusions: The woodworking program promoted psychosocial health, such as life satisfaction, resilience, and social support, among older adults with mild cognitive impairment and mild dementia.
Vehicle Directional Cosine Calculation Method
Authors: Hall Derek , Sands Timothy
Published: November 2022

Teaching kinematic rotations is a daunting task for even some of the most advanced mathematical minds. However, envisioning and explaining the three-dimensional rotations can be highly simplified by changing the paradigm. This paradigm change allows for a high school student with a understanding of geometry to be able to not only develop the matrix but also explain the rotations at a collegiate level. The proposed method includes the assumption of a point (P) within the initial three-dimensional frame with axes (x ̂_i, y ̂_i, z ̂_i). It then utilizes a two-dimensional rotation view (2DRV) to measure how the coordinates of point P translate after the initial axis is rotated instead of using the established Euler's formula. The equations are used in matrix notation to develop a direction cosine matrix (DCM) for future equations. This method provides a high school student with an elementary and repeatable process to compose and explain kinematic rotations.
Deciphering Tumour Microenvironment of Liver Cancer through Deconvolution of Bulk RNA-seq Data with Single-cell Atlas
Authors: Zhang Shaoshi , Bacon Wendi , Peppelenbosch Maikel P. , Kemenade Folkert van , Stubbs Andrew P.
Published: November 2022

Liver cancers give rise to a heavy burden of health care worldwide. Understanding the tumour microenvironment (TME) underpins the development of precision therapy. Single-cell RNA sequencing (scRNA-seq) technology has generated high-quality cell atlases of the TME, but its wider application faces enormous costs for various clinical circumstances. Fortunately, a variety of deconvolution algorithms can instead repurpose bulk RNA-seq data, alleviating the need for generating scRNA-seq datasets. In this study, we reviewed major public omics databases for relevance in this study and utilized 8 RNA-seq and 1 microarray datasets from clinical studies. To decipher the TME of liver cancer, we estimated the fractions of liver cell components by deconvoluting the samples with Cibersortx using three reference scRNA-seq atlases. We also confirmed that Cibersortx can accurately deconvolute cell types/subtypes of interest. Compared with non-tumorous liver, liver cancers showed multiple decreased cell types forming normal liver microarchitecture, as well as elevated cell types involved in fibrogenesis, abnormal angiogenesis and disturbed immune responses. Survival analysis shows that the fractions of five cell types/subtypes significantly correlated with patient outcomes, indicating potential therapeutic targets. Therefore, deconvolution of bulk RNA-seq data with scRNA-seq atlas references can be a useful tool to help understand the TME.
The Impact of Different Cultivation Practices on Surface Runoff, Soil and Nutrients’ Losses in a Rotational System of Legume – Cereal and Sunflower
Authors: Molla Aikaterini , Skoufogianni Elpiniki , Lolas Alexios , Skordas Konstantinos
Published: November 2022

Soil erosion is one of the biggest problems in the agricultural sector that can affect ecosystems and human societies. A field of 50 slope was selected to study the runoff, soil and nutrients’ loss as well as crop productivity in different treatments (conventional tillage (CT) vs. no-tillage (NT), plant vs. no plant cover, contour cultivation (CC) vs. perpendicular to the contour cultivation, (PC) under natural rainfall. The experiment was conducted in central Greece in two cultivation periods. In autumn, the field was cultivated with intercropping Triticosecale and Pisum sativum and in spring with Sunflower. The total rainfall was 141.4 mm in the 1st year and 311 mm in the 2nd. We found that runoff in the treatment of no tillage with contour cultivation was 85% lower in both years compared to the no tillage-no plant control. Therefore, the contour cultivation-no tillage treatment had a positively effect in decreasing phosphorus and potassium concentrations lost from soil: indeed, there was a decrease by 55% and 62% in P and K, respectively, in the NT compared to the CC treatments. We conclude that the NT-CC treatment with plant cover was the most effective in reducing water runoff, soil nutrients’ loss and increasing yield.
Gıda Güvencesini Arttırmaya Yönelik Sürdürülebilir Tarım ve Çevre Politikaları
Authors: SERTYEŞİLIŞIK Egemen
Published: November 2022

Günümüzde yaşanan iklim değişikliği küresel gıda güvencesini, gıda üretimini ve tedarik zincirini etkilemekte iken küresel nüfusun önemli bir kesimi gıda sıkıntısı çekmekte veya yeterli beslenememektedir. Küresel ısınma ve bozulan doğal dengede tarımsal üretimi etkileyen doğal afetlerin ve salgınların çıkması kaçınılmazdır. Bu çalışmanın amacı gıda güvencesini arttırmaya yönelik sürdürülebilir tarım ve çevre politikaları kapsamında gıda güvencesi politikalarının önemini vurgulayarak gıda güvencesizliğinin nedenlerini ve etkilerini inceleyerek sürdürülebilir kalkınma, tarım ve çevre politikaları kapsamında gıda güvencesini arttırmaya yönelik önerilere altyapı geliştirmektir. Kaynak taraması yapılarak gıda güvencesizliğinin nedenleri ve etkileri incelenerek, gıda güvencesinin sürdürülebilir kalkınmadaki önemi vurgulanmıştır. Tarım ve sürdürülebilir tarım ve çevre politikaları sürdürülebilir kalkınmanın önemli bir unsuru olup insanların refahını ve sağlığını, ülkelerin sağlık harcamalarını, güvencesini, tarımsal ticaretini ve ekonomisini etkileyebilmektedir. Gıda güvencesi ve sürdürülebilir kalkınma ilişkisinin sürdürülebilir tarım ve çevre politikalarının hazırlanmasında ve uygulanmasında göz önünde bulundurularak sürdürülebilir kalkınma politikaları kapsamında ele alınması gereği giderek daha önemli olmaktadır. Dünyadaki gıda probleminin çözümünün ve gıda güvencesinin sağlanması ve gıda atığının engellenmesi için ülkelerin ve gıda üreticilerinin gıda güvencesini sağlamada ve desteklemede iş birliği yapması önemli rol oynayacaktır.
Large libraries of single-chain trimer peptide-MHCs enable rapid antigen-specific CD8+ T cell discovery and analysis
Authors: Heath James , Chour William , Choi Jongchan , Xie Jingyi , Chaffee Mary , Schmitt Thomas , Finton Kathryn , Delucia Diana , Xu Alexander , Su Yapeng , Chen Daniel , Zhang Rongyu , Yuan dan , Hong Sunga , Ng Alphonsus , Butler Jonah , Edmark Rick , Jones Lesley , Murray Kim , Peng Songming , Li Guideng , Strong Roland , Lee John , Goldman Jason , Greenberg Philip
Published: November 2022

CD8 + cytotoxic T cell responses against viral infection represent a major element of the adaptive immune response. We describe the development of a peptide antigen – major histompatibility complex (pMHC) library representing the full SARS-CoV-2 viral proteome, and comprised of 634 pMHC multimers representing the A*02.01, A*24.02, and B*07.02 HLA alleles, as well as specific antigens associated with the cytomegalovirus (CMV). These libraries were used to capture non-expanded CD8 + T cells from blood samples collected from 64 infected individuals, and then analyzed using single cell RNA-seq. The discovery and characterization of antigen-specific CD8+ T cell clonotypes typically involves the labor-intensive synthesis and construction of peptide-MHC tetramers. We adapted single-chain trimer (SCT) technologies into a high throughput platform for pMHC library generation, showing that hundreds can be rapidly prepared across multiple Class I HLA alleles. We used this platform to explore the impact of peptide and SCT template mutations on protein expression yield, thermal stability, and functionality. SCT libraries were an efficient tool for identifying T cells recognizing commonly reported viral epitopes. We then constructed SCT libraries designed to capture SARS-CoV-2 specific CD8+ T cells from COVID-19 participants and healthy donors. The immunogenicity of these epitopes was validated by functional assays of T cells with cloned TCRs captured using SCT libraries. These technologies should enable the rapid analyses of peptide-based T cell responses across several contexts, including autoimmunity, cancer, or infectious disease.
Effectiveness of laughter augmented Tai Chi exercises on physical and psychosocial aspects of Active Aging in community-dwelling older adults: A Systematic Review
Authors: Bibi Rashida , Yan Zhang , Yue Gao
Published: November 2022

Background
Tai Chi augmented with self-induce laughter (SIL) might be an affordable and effective strategy to improve physical and psychosocial aspect of Active Aging among community-dwelling older adults with or without illness. However, research is required to evaluate the synergic effect of augmented TC for community-dwelling older adults and its outcomes. This research aims to critically assess the claimed advantages of Tai Chi exercise augmented with laughter therapy (TC)&(SILT) can improve physical, and psychosocial aspects of Active Aging in community based older adults.
Methods
researcher conducted an extensive literature search from different databases, and returned 1025 research papers. Searching strategies were followed. The time interval was fixed from 2015 to 2021 to minimize searched papers quantity. Only English language, randomized control trials, and quasi-experimental studies were selected due to novelty of the Tai chi in most of the countries. Only 11 papers met the inclusion criteria of our comprehensive review.
Results
The qualitative assessment resulted that programs containing more fun-based interventions are effective regardless of the type of intervention. The effectiveness is also modulated by other variables such as the participant's education level, gender, current health status, and financial constraints.
Conclusion
This review suggests that the Tai Chi movement blended with laughter could be an effective, feasible, and safe interventional strategy which has positive effects on physical and psychosocial health which of Active Aging status and overall well-being in healthy and non-healthy individuals in old age.
Evaluating a User Interface (Prototype) of a Smart Patient- Oriented Obstetric Ultrasound Report (SPOUR): Second Trimester Report
Authors: Alanazi Eman , Luo Jake , Alanzi Turki M , Wu Min
Published: November 2022

Aim
To evaluate a new obstetric ultrasound report for second trimester scan. In this new designed report, we adopted several ideas related to artificial intelligence applications and UX design principles to mitigate patients’ information needs and increase women understanding of the report.
Method:
This is an interventional study compared a traditionally designed report with our new designed report. We used Amazon Mechanical Turk to recruit childbearing age women who are or were pregnant. We used five evaluation concepts: report understanding, perceived ease of use, perceived usefulness, intention to use, and perceived aesthetics. We also measured the perceived ease of use and perceived usefulness of the new components in the report by asking the interventional group about the new components.
Result:
Understanding the report increased in comparison to the old design P = < 003. We found a significant difference of the Perceived ease of use, perceived usefulness, intention to use, and perceived esthetics in the new designed report comparing to the traditional design. We found that the new components were perceived as easy to use and useful by the majority of respondents.
Conclusion:
The new report increased information understanding among pregnant women. User experience design was one of the aspects we looked at when developing the report. The results showed that understanding the report was higher among the interventional group, demonstrating that reporting through patient portal should take advantage of technology advancements to ensure information is understandable by patients.
Increased RBPs associated with HPV play a role in reducing the survival of patients with head and neck cancer
Authors: Kamli Hossam , Jalil Luay Hatem , Mohammed Nawres Bahaa , Jalil Abduladheem Turki , Mustafa Yasser Fakri , Al-Hamdani Mais Mazin , Samarghandian Saeed , Hashemi Mehrdad
Published: November 2022

Objective Head and neck cancer (HNSC) is the sixth most usual type of cancer in the world. The heterogeneity of this type of cancer is more elevated by the rising rate of human papillomavirus (HPV)-related (HPV+) HNSC, which defines an etiological subtype significantly different from the more common tobacco and alcohol associated HPV-negative (HPV-) HNSC. The aim of this study was to identify the RNA-binding proteins (RBPs) with immune role, and study of their relation with HPV status and drug resistance. Methods By using the Cancer Genome Atlas (TCGA) and utilizing clinical data, at the first, differential expressed RBPs analysis was performed and among selected RBPs, the genes which consider as immune genes were identified. Then, downstream analyses to characterize this tumor based on HPV status, including pathway mapping, survival analysis, immune infiltration and drug resistance was conducted. Results 99 differentially expressed genes were detected that were similar in RBPs genes and immune genes (IGs) in HNSC. These genes were enriched in some significant pathway and the association of candidate genes with HPV were applied by Chi-squared test and the level of which were evaluated in HPV + and HPV -. Then, the prognostic value of genes was evaluated in HPV + and the correlation of them with immune infiltration and drug resistance was evaluated. Conclusions Identifying the RBPs with immune role and recognizing the molecular differences between HPV + and HPV − tumors could cause the opportunity to find specific genes and the therapeutic approaches for targeting them.
Essential nutrient intakes and plasma amino acid concentration in cats with obesity undergoing either complete or partial weight reduction
Authors: German Alexander J. , Woods-Lee Georgiana R.T. , Biourge Vincent , Flanagan John
Published: November 2022

Limited data are available regarding essential nutrient intake during weight reduction in cats with obesity fed a therapeutic diet. Fifty-three cats were included in this non-randomised observational cohort study. Weight loss outcomes and body composition changes were assessed in cats undergoing either complete (44 cats, 81%) or partial (9 cats, 19%) weight reduction. Essential nutrient intake during weight reduction was compared with European Pet Food Industry Federation (FEDIAF) and National Research Council (NRC; MR: minimum requirements; AI: adequate intake; RA: recommended allowance) recommendations. All cats remained healthy losing a median (range) of 23% (10–41%) of starting body weight over 221 days (54–976 days). There were no differences in duration, percentage weight loss or rate of weight loss between cats that underwent a complete versus partial weight loss regimen. However, whilst lean mass decreased significantly in cats undergoing complete weight reduction (before 4.2 kg, 2.6–5.7 kg; after 3.9 kg, 2.8–5.2 kg, P < 0.001), there was no change in cats undergoing partial weight reduction (before 3.4 kg, 2.8–4.7 kg; after 3.4 kg, 2.9–4.6 kg, P = 0.109). Average daily selenium intake was less than NRC AI and RA in 40 cats (75%), and less than FEDIAF recommendation in 31 cats (58%), whilst average daily choline intake was less than NRC MR, NRC RA and FEDIAF recommendations in 20 (38%), 50 (94%) and 48 (91%) cats, respectively. Intakes of phenylalanine/tyrosine and potassium were marginally less than recommendations in a minority (≤ 13%) of cats. No other essential nutrient deficiencies were observed. In conclusion, widespread essential nutrient deficiencies are not observed when purpose-formulated therapeutic diets are used for either partial or complete weight reduction in cats with obesity. Partial weight reduction protocols might minimise lean tissue loss in cats during weight reduction, and can be used for older cats and those with severe obesity.
Social inequality in health in married or cohabiting individuals with cardiovascular disease: a population-based study combining survey and register data
Authors: Sørensen Jes Bak , Friis Karina , Maribo Thomas , Nissen Nina Konstantin , Nielsen Berit Kjaerside , Mejdahl Caroline Trillingsgaard , Thomsen Anne Marie Ladehoff
Published: November 2022

Background.
Cohabitation status and educational attainment affect a number of cardiovascular disease (CVD) risk factors and also CVD incidence and mortality. However, little is known about social inequality in CVD risk factors in married or cohabiting (married/cohabiting) individuals with CVD. Following this married/cohabiting individuals with CVD and low educational attainment may be an overlooked group with an increased risk of recurrent CVD events. The aim of this study was to address social inequality in health among married/cohabiting individuals with CVD by examining educational differences in health behaviour, mental health and health literacy.
Methods.
Register data on CVD and cohabitation status were linked with self-reported health behaviour, mental health and one dimension of health literacy (the ability to understand health information) from the population-based health survey "How are you?" carried out in Central Denmark Region in 2017. Self-reported educational attainment was used as a marker for social position. In total, 20,585 (69%) participants aged 45 years and above completed the questionnaire. The analytical sample in this study consisted of 1,794 married/cohabiting individuals with CVD.
Results.
Married/cohabiting individuals with CVD and low educational attainment had higher adjusted odds for daily smoking (AOR 3.31, 95% CI 1.87;5.87), physical inactivity (AOR 2.10, 95% CI 1.37;3.22), unhealthy diet (AOR 6.37, 95% CI 3.29;12.3) and obesity (AOR 2.55, 95% CI 1.60;4.07) than their high educational attainment counterparts. Furthermore, they had higher levels of perceived stress (Aβ 2.31, 95% CI 1.19;3.43) and lower levels of health literacy (Aβ -0.26, 95% CI -0.36;-0.16) and mental health-related quality of life (Aβ -1.80, 95% CI -3.53;-0.07). Finally, they had lower adjusted odds for moderate/high risk alcohol intake (AOR 0.35, 95% CI 0.20;0.60).
Conclusion.
We found increased CVD risk factors and thus increased risk of recurrent CVD events in married/cohabiting individuals with CVD and low educational attainment compared to married/cohabiting individuals with CVD and high educational attainment. The social inequality in health behaviour, mental health and health literacy among married/cohabiting individuals with CVD should be addressed in both public health strategies, targeted secondary prevention, treatment and rehabilitation.
Many-body reduced vector solution and water vibrations
Authors: Abdel-Rahman A. S.
Published: November 2022

Reduced mass value and vector are well known for the two-body problem, but the many-body reduced vector problem is not solved yet. The study of many-body problems and their applications (such as vibrational spectroscopy) is one of the more important physical problems. Vibrational spectroscopy provides a powerful tool to perceive the molecular structures and atom motions of molecules. The water molecule is a three-body system stretching vibration that has been previously quantized; their frequencies were defined and showed the infrared (IR) absorption spectrum based on Morse potential. In this work, the reduced mass of the many-body problem is being solved and then used to study the intensity of the stretching vibration modes and show the ratio is in agreement with experiments. The molecule was studied in classical and quantum mechanics to determine its absorption intensity as an example of a reduced mass problem. The results show molecular atomic motions and changes in dipole and reduced mass vector. A Morse-like model for bending was predicted based on the spectroscopic vibration frequency and intensity, defining the bending potential depth of 93.5 kJ/mol.
New constraints on axion-like dark matter from a SERF comagnetometer
Authors: Bloch Itay , Shaham Roy , Hochberg Yonit , Kuflik Eric , Volansky Tomer , Katz Or
Published: November 2022

Ultralight axion-like particles are well-motivated relics that might compose the cosmological dark matter and source anomalous time-dependent magnetic fields. We report on new terrestrial bounds from the Noble And Alkali Spin Detectors for Ultralight Coherent darK matter (NASDUCK) collaboration on the coupling of axion-like particles to neutrons and protons. The detector uses nuclei of noble-gas and alkali-metal atoms and operates in the Spin-Exchange Relaxation-Free (SERF) regime, achieving high sensitivity to axion-like dark matter fields. Conducting a month-long search, we cover the mass range of 1.4×10-12 eV/c2 to 2×10-10 eV/c2 and provide world-leading limits which supersede robust astrophysical bounds, and improve upon previous terrestrial constraints by up to two orders of magnitudes for many masses within this range. These are the first reliable terrestrial bounds reported on the coupling of protons with axion-like dark matter, covering a new and unexplored terrain in its parameter space.
Knowledge, Beliefs, and Practices of a Cambodian Traditional Postpartum Medicine, Sra Thnam, among Cambodian Women (15-30 Years) Living in Massachusetts.
Authors: Cordeiro Lorraine S. , Ahnan-Winarno Amadeus D. , Dou Nan , Sibeko Lindiwe , Johns Timothy , Mouth Ronnie , Nelson-Peterman Jerusha
Published: November 2022

Background: Cambodian refugees arrived in the U.S. with limited English proficiency, low educational attainment, poor health status, and significant trauma. Combined with poor healthcare access, this fostered an environment for continued reliance on cultural health practices. Maternal health, including the postpartum period, was particularly influenced by traditional Cambodian medicine. This study investigated associations between sociodemographic factors and Cambodian women’s knowledge, beliefs, and practices related to sra thnam, a traditional postpartum medicine used in the Cambodian diaspora.
Methods: This cross-sectional study was conducted with Cambodian women ages 15-35 years (N=162) living in Massachusetts. A community-academic team developed study materials and administered surveys and focus groups on knowledge, beliefs, and use of sra thnam. Focus group discussions were entered into NVivo 10. Survey data was analyzed using Stata version 14.0 and SPSS version 27. A series of statistical analyses were performed to assess associations between participant use of sra thnam and socio-demographic, health, and psychometric factors.
Results: Knowledge of sra thnam was almost universal (92%), with 44% these participants reporting ever consuming it. Pregnant women (N=56) reported not having consumed sra thnam during the current pregnancy and after childbirth, 52% reported an intention to consume sra thnam, 42.9% did not, and 5.4% were uncertain. After adjusting for covariates, being born in the U.S., having at least one child, older age, and larger households were predictive of ever consuming sra thnam.
Conclusion: These findings show traditional postpartum knowledge and practices are common among Cambodian women living in the U.S. These practices may have benefits, as well as pose some risks, for maternal health. Given that perceptions of pregnancy, childbirth, and postpartum experiences are nested in culture, it is important that healthcare providers are aware of traditional health beliefs and practices in refugee and immigrant communities. Greater understanding of traditional postpartum practices can facilitate culturally relevant support and health care services to mothers.
Identification of PRIM2 as a new prognostic and immune-related marker in cancer based on a comprehensive pan-cancer analysis
Authors: Jiang Jinqun , Lu Hai
Published: November 2022

DNA Primase Subunit 2 (PRIM2) encodes a large subunit (p58C) of DNA primase, which plays an important role in DNA replication. However, the role of PRIM2 in cancer and immune regulation has not been elucidated. Therefore, in the present study, the expression profile of PRIM2 in cancer was investigated using publicly available databases like the Cancer Genome Atlas (TCGA), the Genotype-Tissue Expression (GTEx), the Broad Institute Cancer Cell Line Encyclopedia (CCLE) from the University of California Santa Cruz (UCSC) Xena website. PRIM2 expression was analyzed in paired normal to the adjacent tumor and unpaired cancer and normal tissues. The prognosis of PRIM2 in various cancers was studied using Cox regression and Kaplan-Meier analysis. The relationship between PRIM2 and tumor staging, tumor mutation burden (TMB), and microsatellite instability (MSI) was analyzed. Algorithms like cell type identification by estimating relative subsets of RNA transcripts (CIBERSORT), xCell, ssGSEA, and MCP-counter were used to study the correlation between PRIMA2 and tumor immune microenvironment, immune infiltrating cells, and immune-related genes (antigen processing and presentation genes, chemokines, chemokine receptors, HLA-related genes, immune checkpoints). Further, the correlation between PRIM2 and methyltransferase (DNMT1, DNMT3A, DNMT3B) from different databases. The biological processes and signaling pathways associated with PRIM2 in various tumors were studied. Finally, the correlation between the PRIM2 and the sensitivity of multiple drugs was analyzed using the National Cancer Institute (NCI)-60 database. The results show that PRIM2 was up-regulated in most tumors, high PRIM2 expression was associated with the different stages of cancer, and poor prognosis was observed. The results indicate that PRIM2 could potentially be used as a prognostic and immunotherapy target in tumors.
Predictive factors of egg allergy clinical outcomes in infants and young children
Authors: mo xiaoyan , lv jiajia , shao jie
Published: November 2022

Aim: To explore the tolerance march in children and identify potential factors that affect the prognosis of egg allergy (EA).
Methods: Two hundred children(age range, 6 months-2.5 years)with atopic dermatitis (AD) were recruited from 2018 to 2019. EA was diagnosed based on medical history, skin prick test (SPT), and the oral food challenge (OFC) test. EA was diagnosed in 78 children; among these, 7 were allergic only to egg yolk (Only EYA), 20 to egg white (Only EWA), and 51 to whole egg (WEA). Logistic regression analysis was used to identify risk factors for outcomes during the disease course. Receiver operating characteristic (ROC) curve analysis was performed to establish a predicting model.
Results: The Scoring Atopic Dermatitis score in the WEA group was more severe and persistent than that in the other groups. Forty-three cases of EA developed clinical tolerance (average age, 32.3 ± 8.7 months). The tolerance rate of EYA and EWA was 75.9% and 56.3%, respectively. The SPT wheal diameter at initial diagnosis (SPTdiag) was a risk factor for persistent EA. The SPT wheal diameter after 6 months (△SPT6mo) in the tolerant group was markedly decreased compared to that in the persistent EA group. Tolerance was higher when △EW-SPT6mo ≥ 39.5% or △EY-SPT6mo ≥ 27%.
Conclusion: The initial SPTdiag and SPT6mo values were significantly correlated with and can predict outcomes of EA.
Prevalence and Risk Factors of Lung Worm Infection in Small Ruminants in Selected Districts of Wolaita Zone, Snnprs, Ethiopia
Authors: Tora Ephrem , Tessema Wondimu , Getachew Minale
Published: November 2022

The lungworm is an important parasitic nematode of small ruminants that infects the lower respiratory tract and is associated with high mortality and morbidity. However, the level of lungworm infection in the study districts is not known. A cross-sectional study was conducted from December 2019 to June 2020 in selected Districts of Wolaita Zone with the objectives of determining the prevalence of lungworm infection and associated risk factors. Modified Baermann techniques were used for identification of the lungworms from fecal samples. A total of 742 fecal samples from 443 sheep and 299 goats were collected and examined. Lungworms were detected in 271(36.52%) samples. The parasites infected 192 (43.34%) and 79 (26.42%) of sheep and goats respectively. Lungworm species Dictyocaulus filaria, Protostrongylus rufescens and Muellerius capillaries were identified in 114(15.36%), 68(9.16%) and 57(7.68%) fecal samples respectively. Mixed infection by two or more above species was noted in 32 (4.31%) of the samples. Among the epidemiological factors examined, agro-ecology, management system, and season showed statistically significant differences (P < 0.05) with overall lungworm prevalence in sheep and goats. On the other hand, lungworm infection among sexes, age groups and body condition scores showed no statistically significant difference (P > 0.05). The present study indicated that lungworm infection was a common problem for sheep and goats in the study area. So, measures like de-worming, early treatment and improving animal husbandry should be practiced.
Study on vertical load distribution of pile group-liquefied soil system under horizontal earthquake
Authors: Huang Zhanfang , Bai Lichao , Su Tian , Bai Xiaohong , Zheng Junjie , Liu Yongqiang
Published: November 2022

The dynamic response of pile-liquefied soil is a complex problem. Based on the shaking table test test, the vertical bearing characteristics of pile foundation - liquefied soil system under simulated horizontal seismic force are analyzed and studied with the help of MIDAS GTS three-dimensional finite element analysis software. Study the load borne by the pile top under horizontal earthquake with a certain vertical load, different pile spacing and different vibration time, The cumulative coefficient CCPF of pile side friction is introduced. At different vibration times the distribution of CCPF along the pile body of single pile and pile groups with different pile spacing is analyzed, it is concluded that CCPF can intuitively reflect the distribution law of pile side friction during vibration. When the value of CCPF at the pile bottom is equal to 1, it means that the load actually acting on the pile top is equal to the average value of the total load. When CCPF at the pile bottom is less than 1, it means that the load on the pile top is less than the average value of the total load. When CCPF at pile bottom is greater than 1, it indicates the load on the pile top is greater than the average of the total load.
Responses of photosynthesis and chlorophyll fluorescence during light induction in different seedling ages of Mahonia oiwakensis
Authors: Chen Chung-I , Lin Kuan-Hung , Lin Tzu-Chao , Huang Meng-Yuan , Chen Yung-Chih , Huang Chau-Ching , Wang Ching-Wen
Published: November 2022

Background
The aim of this study was to determine the actual state of the photosynthetic apparatus and exhibit distinguishable differences in the chlorophyll fluorescence (ChlF) components in different seedling ages of M. oiwakensis plants subjected to different light intensity (LI), that reflected their adaptability to their habitats and how they responded to LI changes. Potted 6-month-old greenhouse seedlings and field collected 2.4-year-old seedlings with 5 cm heights were selected and randomly separated into seven groups for photosynthesis measurements illuminated with 50, 100 (assigned as low LI), 300, 500, 1,000 (as moderate LI), 1,500 and 2,000 (as high LI) µmol m–2 s–1 photosynthetic photon flux density (PPFD) treatments.
Results
In 6-month-seedlings, as LI increased from 50 to 2,000 PPFD, the values of non-photochemical quenching and photoinhibitory quecnhing (qI) increased but potential quantum efficiency of PSII (Fv/Fm) and ΦPSII values decreased, indicating adaptation to low LI conditions. High electron transport rate, actual PSII efficiency %, and Fv/Fm% values were observed in 2.4-year-old seedlings at high LI conditions, suggesting that these seedlings can have higher photoprotective ability under high LI treatments to maintain higher photosynthetic system performance. Furthermore, higher ΦPSII was detected under low LI conditions, with lower energy-dependent quenching (qE) and qI values and photo-inhibition % decreased as well. However, qE and qI increased as ΦPSII decreased and photo-inhibition% increased under high LI treatments.
Conclusions
These results could be useful for predicting the changes in growth and distribution of Mahonia species grown in controlled environments and open fields with various combinations of varying light illuminations, and ecological monitoring of their restoration and habitat creation is important for provenance conservation and helps to formulate better conservation strategies.
Beyond consensus sequence: a quantitative scheme for inferring transmission using deep sequencing in a bacterial transmission model
Authors: Senghore Madikay , Read Hannah , Oza Priyali , Johnson Sarah , Passarelli-Araujo Hemanoel , Taylor Bradford , Ashley Stephen , Grey Alexander , Callendrello Alanna , Lee Robyn , Goddard Matthew , Lumley Thomas , Hanage William , Wiles Siouxsie
Published: November 2022

Genomic surveillance provides a data source complementary to contact tracing to resolve putative transmission chains. However, the role of within-host diversity in transmission is understudied due to a lack of experimental and clinical datasets that capture within-host diversity in both donors and recipients. Here, we assess the utility of deep-sequenced genomic surveillance within a mouse transmission model where the gastrointestinal pathogen Citrobacter rodentium was controllably spread during co-housing of infected and naïve animals. We observed that within-host variants were maintained over multiple transmission steps until fixation or elimination. We present a model for inferring the likelihood that a given pair of samples are linked by transmission, by comparing the allelic frequency at variant genomic loci. Our data affirm that within-host single nucleotide variants (iSNVs) can repeatedly pass from donor to recipient along the transmission chain, and the mere sharing of iSNVs between different transmission pairs offers limited confidence in identifying a transmission pair. Beyond the presence and absence of within-host variants, we show that differences arising in the relative abundance of iSNVs can infer transmission pairs with high precision. An important component of our approach is that the inference is based solely on sequence data, without incorporating epidemiological or demographic data for context. Our model, which substantially reduces the number of comparisons a contact tracer needs to consider, may enhance the accuracy of contact tracing and other epidemiological processes, including early detection of emerging transmission clusters.
Diagnostic delay in multiple myeloma: the legacy of the COVID-19 pandemic.
Authors: Carmichael Jonathan , Seymour Frances , Mcilroy Graham , Tayabali Sarrah , Amerikanou Rodothea , Feyler Sylvia , Aung June , Popat Rakesh , Pratt Guy , Parrish Christopher , Ashcroft John , Jackson Graham , Cook Gordon
Published: November 2022

The COVID-19 pandemic has had global healthcare impacts, including high mortality from SARS-CoV-2 infection in cancer patients; individuals with multiple myeloma (MM) are es-pecially susceptible to poor outcomes. However, even for MM patients who avoided severe infection, the ramifications of the pandemic have been considerable. The consequences of necessary socio-geographical behavior adaptation, including prolonged shielding and inter-ruptions in delivery of non-pandemic medical services are yet to be fully understood. Using a real-world dataset of 323 consecutive newly diagnosed MM patients in England, we in-vestigated the impact of the COVID-19 pandemic on routes to myeloma diagnosis, disease stage at presentation and relevant clinical outcomes. We demonstrate increasing MM presentations via emergency services and increased rates of bony and extra-medullary dis-ease. Differences were seen in choice of induction therapy and the proportion of eligible patients undertaking autologous stem cell transplantation. Whilst survival was statistically inferior for emergency presentations, significant survival differences have yet to be demon-strated for the entire cohort diagnosed during the pandemic, making extended follow-up critical in this group. This dataset highlights wide-ranging issues facing MM patients conse-quent of the COVID-19 pandemic, with full impacts for clinicians and policy-makers yet to be elucidated.