bluuebunny/crossref_metadata_2025 huggingface dataset:
Behavioral Variant Frontotemporal Dementia
Authors: Boeve Bradley F.
Published: June 2022

PURPOSE OF REVIEW

This article reviews many of the complex facets of behavioral variant frontotemporal dementia (bvFTD) and frontotemporal lobar degeneration (FTLD). A particular focus is on improving diagnostic accuracy to reduce the arduous diagnostic odyssey that so many patients and families endure. Strategies to promote diagnostic accuracy and approach the management of problematic symptoms are also discussed.

RECENT FINDINGS

Although the International Consensus Criteria for bvFTD were published more than a decade ago and clinicopathologic studies have confirmed their utility, diagnostic confusion continues. This article presents updated data along with illustrative cases to emphasize the clinical pearls that are most useful for clinicians. Although accurate prediction of the underlying proteinopathy remains a challenge, the ability to differentiate bvFTD from atypical Alzheimer disease, psychiatric disorders, and other mimickers has improved. Knowledge about the genetic underpinnings in a significant minority of individuals with familial FTLD is enabling early and accurate diagnosis. Therapeutic optimism has also increased, particularly in familial FTLD, with a few clinical trials in progress and several more planned, some of which are designed to slow progression or delay the onset of symptoms, or both.

The diagnosis and management of bvFTD is challenging for clinicians and particularly for patients and their families. Although much progress has been gained over recent years, several key research questions persist. Treatments that significantly improve symptoms or alter the course of FTLD remain elusive, but optimism is increasing as pathobiology is better understood and novel therapies are being developed.
Management of Dementia
Authors: Carlsson Cynthia M.
Published: June 2022

PURPOSE OF REVIEW

This article describes an approach to managing patients following a diagnosis of dementia, including medical management, nonpharmacologic strategies, safety interventions, caregiver support, mobilization of community resources, and advanced care planning.

RECENT FINDINGS

Dementia clinical syndromes are frequently caused by mixed pathologies, leading to varied clinical presentations that include memory loss, behavioral changes, communication challenges, safety concerns, and loss of independent function. Medications for treating dementia currently target cognitive and behavioral symptoms, although disease-modifying therapies for Alzheimer disease may be making their way into widespread clinical practice soon. Identification and treatment of co-occurring medical problems, such as obstructive sleep apnea, adverse medication effects, mood disorders, hearing loss, pain, alcohol misuse, and vascular risk factors, may mitigate the impact of these conditions on cognitive decline. Mobilization of clinical and community-based interprofessional teams will ensure that people with dementia and their care partners have the expertise, support, and access to resources they need. Addressing goals of care early in the disease course will allow people with dementia to contribute to their care plan by expressing their wishes.

Developing a structured approach to treating common causes of dementia and related comorbid medical conditions, identifying a local network of interprofessional clinical and community-based referrals, and providing readily available educational resources will help clinicians provide quality dementia care management that extends beyond the clinic visit. Encouraging patients and families to engage in clinical research will advance the identification of effective therapies, preventive strategies, and quality care models for the future.
Neuropathology of Dementia Disorders
Authors: Schneider Julie A.
Published: June 2022

PURPOSE OF REVIEW

This article provides an overview of the neuropathology of common age-related dementing disorders, focusing on the pathologies that underlie Alzheimer disease (AD) and related dementias, including Lewy body dementias, frontotemporal dementia, vascular dementia, limbic-predominant age-related transactive response DNA-binding protein 43 (TDP-43) encephalopathy (LATE), and mixed-etiology dementias. This article also discusses the underlying proteinopathies of neurodegenerative diseases (eg, amyloid-β, paired helical filament tau, α-synuclein, and TDP-43 pathology) and vascular pathologies, including tissue injury (eg, infarcts, hemorrhages) with or without vessel disease.

RECENT FINDINGS

New criteria for AD pathologic diagnosis highlight amyloid-β as the sine qua non of AD; they require molecular markers of amyloid and establish a minimum threshold of Braak neurofibrillary tangle stage 3. Pathologic diagnosis is separated from clinical disease (ie, pathologic diagnosis no longer requires dementia). TDP-43 pathology, a major pathology in a frontotemporal dementia subtype, was found as a central pathology in LATE, a newly named amnestic disorder. Multiple pathologies (often co-occurring with AD) contribute to dementia and add complexity to the clinical picture. Conversely, Lewy body, LATE, and vascular dementias often have accompanying AD pathology. Pathology and biomarker studies highlight subclinical pathologies in older people without cognitive impairment. This resilience to brain pathology is common and is known as cognitive reserve.

The pathologies of dementia in aging are most commonly amyloid, tangles, Lewy bodies, TDP-43, hippocampal sclerosis, and vascular pathologies. These pathologies often co-occur (mixed pathologies), which may make specific clinical diagnoses difficult. In addition, dementia-related pathologies are often subclinical, suggesting varying levels of resilience in older people.
Then and Now: Japanese Women Photographers of the 1970s and '80s Revealed Through Their Photobooks
Authors: Lederman Russet
Published: June 2022

This paper uses Asian naming conventions: that is, last name preceding first name. Yoko Ono is the exception, as she is well known in the West by that name. Unless otherwise noted, all translations of Japanese texts are by Tomomitsu Megumi.
Psychology and Cybernetics
Authors: Koletsi Maria
Published: June 2022

Cyberpsychology is an emerged field in Social Sciences concerned with control and communication of humans and machines focusing on Psychology and Communication Studies. In its generalized form operates as a thematic “umbrella” for all branches of Psychology and Communication employing different methodologies, methods and techniques related to interactive, cognitive and behavioral phenomena that are observed on the internet and social media. As a special science, in the form of Cybernetic Psychology, is focusing on the mechanisms of cognitive control of perception, information and behavior. It targets the programmable simulation of these phenomena; their algorithmic representation and the feedback learning processes that allow adaptation in cyberspace. Issues as integration of everyday life in digital context, management in governance, problem-solving in human-machine interaction, consulting and therapy assistance to practitioners, establish Cyberpsychology and Cybernetic Psychology as areas that contribute and furthering the scientific knowledge of successful or failed human evolutionary processes and strategies. Homo Virtualis as cybernetic organism seeks to maintain and strengthen control over itself, the others and machines, in digital environments, through cognitive, behavioral and affective processes. The paper attempts an introduction to questions regarding the dimensions of the ontological basis of Cybernetic Psychology as foundation of general Cyberpsychology. The special issue “Initiation to Cyber-Psychology: A Students’ Research Anthology” is dedicated to the work of undergraduate students of the Psychology Department of Panteion University of Social and Political Sciences. Students’ papers were prepared within the “Cyberpsychology” course, taught, for the first time as a compulsory, during the spring semester of the academic year 2020-2021.
From Lewis Carroll’s “Alice in Wonderland” to “Alice on social media”: Approaches of fantasy as a real experience in Cyberspace
Authors: Hadjieustathiou Marilena , Ioannou Andreas , Karfitsa Aggelikh , Paliari Anna , Skantzouri Maria
Published: June 2022

In the present study, we implement the theory of Hermeneutics in order to understand the element of reality in the virtual world experience. We attempted to formulate cases on the user experiences and interpret them, as described in existing research and reflected on social media. Our focus topic consists of the use of imagination and its contribution to the construction of identity, behavior and relationships in the virtual environment of social media. We also make references to the elements of irrationality and time, two variables that are likely to affect the way users perceive reality. The online methodological tools and programs Concept-mapping and Social Network Visualiser were used in order to collect and capture the mentioned and further related concepts as well. The results of the study include possible conceptual correlations in social media, for which we argue that their virtuality depends on the actions of the user, and individual conclusions about the function of the imagination, which we consider to be an integral part of conception, implementation and quality of reality.
Social Robots: The case of Robot Sophia
Authors: Kouravanas Nikolaos , Pavlopoulos Andreas
Published: June 2022

In recent years there has been an increasing use of robots in various areas of public and private life. This leads to a set of ethical, social and interpersonal dilemmas. The subject of this paper concerns attitudes towards social robots, starting with the issue of citizenship and moving on to the roles that can be attributed to a robot with Artificial Intelligence. A central example was the social robot Sophia, which has artificial intelligence, and it has been given to it a citizenship. In order to investigate the issue, a literature review of previous research articles related to social robots was initially conducted. An attitudes’ questionnaire was then constructed, to which 137 participants answered. The results showed that, the majority of the sample did not want robots to acquire citizenship and equal rights as humans, nor did they want robots to be used for roles involved in interpersonal relationships, such as raising children, work, friendship, or love. In general, it has been observed that the research sample was not particularly prepared for the existence of social robots in society, while they have been associated with negative or malicious purposes. Gender and age also play an important role regarding attitudes towards social robots. However, this is an open issue that leaves much more unanswered questions and concerns.
A quantitative study exploring the acceptance of the eHealth model for mental wellness among digital workers
Authors: Tan Choon Hong , Koo Ah Choo , Rahmat Hawa , Siew Wei Fern , Cheang Alexius Weng Onn , Amir Sharji Elyna
Published: June 2022

Background: eHealth makes use of information and communication technologies (ICT) to improve health. In the digital age, the use of eHealth applications and other health-related applications has gained popularity, particularly during the COVID-19 pandemic. As a result of the pandemic, many uncertainties have arisen, causing stress and affecting the mental health of many skilled workers in the digital industry, particularly in the ICT, computing, and creative media industries. eHealth applications have the potential to benefit people's health. As a prerequisite for effective implementation of eHealth for mental wellness (EHMW), this paper examines the acceptance of EHMW among digital workers in Malaysia. 

The objectives of this research are two-fold: 1) To explore the acceptance of EHMW among digital workers in a local Premier Digital Tech Institution (PDTI), and 2) To explore how these talents' demographic profiles, mental health literacy and workplace wellness influence their acceptance of EHMW.  

Methods: This research surveyed 41 digital workers who played vital roles in providing digital skills at a tertiary education level.   

Results: Most respondents agreed that eHealth was appropriate for managing mental wellness. Among the three eHealth domains for managing mental wellness, the acceptance level is the highest for the application domain of "interacting for health", with male respondents more likely to accept the use of EHMW. 

Conclusions: This small-scale survey could not fully examine the acceptance of eHealth and its usage patterns for mental wellness among digital workers in Malaysia. Future research will target more digital workers in Malaysia. This research addresses the research gap on the eHealth perspectives of digital workers on their acceptance, and the potential influence of demographic profiles, mental health literacy, and workplace wellness on EHMW's acceptance of digital health tools/platforms to promote their mental wellness.
Hidden disability: a study of the psychosocial impact of living with pituitary conditions
Authors: Norman Alyson , Jackson Sue , Ferrario Hannah , McBride Pat
Published: June 2022

Background:

Pituitary patients often experience psychosocial symptoms associated with their condition.

Aims:

To explore the condition management experiences of pituitary patients and their psychosocial symptoms and to explore the impact of these on quality of life.

Methods:

A sample of 748 individuals aged 18 to more than 65 years) completed a questionnaire relating to quality of life and the psychosocial impact of pituitary conditions.

Findings:

Analysis of the qualitative sections using content analysis identified four themes: social isolation, emotional and behavioural issues, appearance distress and physical and cognitive effects including fatigue and pain. An overarching theme of hidden disability emerged.

Conclusion:

The study identified multiple biopsychosocial factors that impact quality of life, with symptoms not visible to others most likely to impact negatively. Nurses are well placed to provide support and information to patients about the possible psychosocial impact of pituitary conditions to enable positive adjustment.
Debating the best way to compensate patients for clinical negligence PART 2
Authors: Tingle John
Published: June 2022

John Tingle, Lecturer in Law, Birmingham Law School, University of Birmingham, continues his unpacking of the report from the Health and Social Care Committee on changes to the system for compensating patients
It's never easy to leave our comfort zone
Authors: Foster Sam
Published: June 2022

Sam Foster, Chief Nurse, Oxford University Hospitals, suggests that putting the focus on both the patient and the staff experience can help leaders to overcome resistance to proposed workplace transformations
Relationship between pressure ulcer risk and sarcopenia in patients with hip fractures
Authors: Cha Yong-Han , Song Sang-Youn , Park Ki-Soo , Yoo Jun-II
Published: June 2022

Objective:

Pressure ulcer (PU) is a frequent complication of hip fractures. PUs can develop at any time after a hip fracture but most appear within 2–4 days after surgery. The purpose of this study was to investigate the association between hip fractures due to sarcopenia and the risk of PUs in patients with hip fracture.

Method:

Between March 2017 and March 2019, patients aged ≥65 years of age with hip fractures were included in this retrospective cohort study. PU risk assessment according to the Braden Scale was performed within the first few hours after arrival at hospital. Skeletal muscle mass index (SMI) and hand grip strength were evaluated for a diagnosis of sarcopenia.

Results:

Of the 289 patients admitted to the study institution, 180 patients were finally enrolled in the study (129 females; 51 males). In male patients, as SMI increased, so too did the Braden Scale score, which was statistically significant (p=0.02). However, there was no statistically significant difference between SMIs and Braden Scale scores in female patients (p=0.304). In male patients, there was no statistically significant difference between hand grip strength and Braden Scale score (p=0.251). However, in female patients, as hand grip strength increased, so too did the Braden Scale score; this was also statistically significant (p=0.041).

Conclusion:

In this study, decreased muscle mass and muscle weakness in patients with hip fractures were associated with increased PU risk as measured by Braden Scale scores in both males and females.
Students’ Career Decision-Making During Online Learning: The Mediating Roles of Self-Efficacy in Vocational Education
Authors: Sutiman Sutiman , Sofyan Herminarto , Soenarto Soenarto , Mutohhari Farid , Nurtanto Muhammad
Published: June 2022

In the last decade, vocational education in Indonesia has experienced problems in making career decisions for students, which was exacerbated by the COVID-19 pandemic. Therefore, this research aims to examine the role of self-efficacy and mediate digital literacy, social environment, and counselling guidance in influencing career decision-making. This is an ex-post-facto research design with data collected from a sample of 566 vocational education students in Indonesia through a questionnaire method distributed online using Google Form. The collected data was then analyzed using structural equation modelling (SEM) with path analysis and bootstrap methods. The results revealed that self-efficacy plays a vital role in mediating digital literacy and guiding students in career decision-making. On the other hand, digital literacy, guidance, and counselling have a significant direct effect on self-efficacy and career decision-making. Meanwhile, the social environment only has a significant direct effect on students’ career decision-making. The real role of all elements of vocational education in strengthening self-efficacy, growing digital literacy, monitoring social environment interactions, and providing counselling guidance to students is needed to increase optimism and the quality of career decision-making in vocational education.
It Doesn't Mean that Students Don't Have Mathematics Anxiety: A Case Study of Mathematics Learning with Path Analysis
Authors: Kusmaryono Imam , Ubaidah Nila , Basir Mochamad Abdul
Published: June 2022

Mathematics anxiety has always been an interesting topic to study and discuss in the world of education. This study aimed to (1) investigate the impact of teacher roles, mathematics content, and mathematics anxiety on learning motivation, and (2) explore how students manage mathematics anxiety as a stimulus in learning motivation. This research used mixed methods with embedded concurrent design. The research sample was 100 respondents. The questionnaire instrument was arranged based on a Likert scale with 5 answer choices. This study used a structural equation model and confirmatory factor analysis as data analysis methods. The research findings indicated that: (1) a significant direct impact emerged between mathematics anxiety and students' learning motivation, and there was an indirect impact between the teacher's role and mathematics content on learning motivation; (2) students could manage mathematics anxiety when they were in optimal anxiety or positive anxiety so that they could overcome mathematics anxiety as a stimulus for achievement and deconstruct anxiety into motivation according to experience and personal resources. Results of this study confirmed that the statements about mathematics anxiety which always has a negative impact on motivation and learning achievement is not universal, because mathematics anxiety does not always have a negative impact on motivation and learning achievement if this anxiety is managed effectively.
Addressing Preservice Teacher’s Reasons for Mathematics and Test Anxiety
Authors: Ersozlu Zara , Blake Damian , Usak Muhammet , Hawken Stuart
Published: June 2022

Mathematics anxiety in initial teacher education is a growing issue that reflects on teacher quality and their student’s maths anxiety and abilities. Previous studies have presented a range of different perspectives to mathematics anxiety. We aimed to explore further the reasons of mathematics anxiety in preservice teachers and suggest some intervention strategies in reducing maths anxiety for initial teacher education systems. We used a mixed methodology in this research analysing both qualitative data along with some quantified data derived from qualitative data sources. The findings provide insights to causes of maths and test anxiety along with some intervention strategies that teacher educators can use in their future teaching.
Human acellular amniotic membrane scaffolds encapsulating juvenile cartilage fragments accelerate the repair of rabbit osteochondral defects
Authors: Jun Zhang , Yuping Wang , Yanran Huang , Ziming Liu , Yuwan Li , Xizhong Zhu , Zhilin Wu , Xiaoji Luo
Published: June 2022

Aims

The purpose of this study was to explore a simple and effective method of preparing human acellular amniotic membrane (HAAM) scaffolds, and explore the effect of HAAM scaffolds with juvenile cartilage fragments (JCFs) on osteochondral defects.

Methods

HAAM scaffolds were constructed via trypsinization from fresh human amniotic membrane (HAM). The characteristics of the HAAM scaffolds were evaluated by haematoxylin and eosin (H&E) staining, picrosirius red staining, type II collagen immunostaining, Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). Human amniotic mesenchymal stem cells (hAMSCs) were isolated, and stemness was verified by multilineage differentiation. Then, third-generation (P3) hAMSCs were seeded on the HAAM scaffolds, and phalloidin staining and SEM were used to detect the growth of hAMSCs on the HAAM scaffolds. Osteochondral defects (diameter: 3.5 mm; depth: 3 mm) were created in the right patellar grooves of 20 New Zealand White rabbits. The rabbits were randomly divided into four groups: the control group (n = 5), the HAAM scaffolds group (n = 5), the JCFs group (n = 5), and the HAAM + JCFs group (n = 5). Macroscopic and histological assessments of the regenerated tissue were evaluated to validate the treatment results at 12 weeks.

Results

In vitro, the HAAM scaffolds had a network structure and possessed abundant collagen. The HAAM scaffolds had good cytocompatibility, and hAMSCs grew well on the HAAM scaffolds. In vivo, the macroscopic scores of the HAAM + JCFs group were significantly higher than those of the other groups. In addition, histological assessments demonstrated that large amounts of hyaline-like cartilage formed in the osteochondral defects in the HAAM + JCFs group. Integration with surrounding normal cartilage and regeneration of subchondral bone in the HAAM + JCFs group were better than those in the other groups.

Conclusion

HAAM scaffolds combined with JCFs promote the regenerative repair of osteochondral defects. Cite this article: Bone Joint Res 2022;11(6):349–361.
Capacidades Digitais Aplicáveis ao Setor Educacional
Authors: De Souza Vieira Silva Rosemeire , Eurico Soares de Noronha Matheus , Sampaio Marina , Doritta Rodrigues Cristina , Amatucci Marcos
Published: June 2022

O objetivo é mapear as capacidades digitais aplicáveis ao setor da educação. O método utilizado é revisão sistemática de literatura do tipo descritiva com análise bibliométrica. Os dados foram coletados nas bases Web of Science e Scopus, considerando o período de 1973 a 2021. Para sistematizar a base de dados foi empregado o software Vosviewer. A amostra selecionada é de 69 artigos. Os resultados mostram cinco competências digitais aplicáveis ao setor educacional: capacidade de aprimoramento digital; capacidade de desenvolver objeto de aprendizagem; capacidade de acessibilidade digital; capacidade de desenvolver plataformas dominantes e capacidade de digitalização dos processos. O estudo contribui para teoria em dois momentos, primeiro ao indicar os principais estudos sobre capacidades digitais aplicáveis ao setor educacional e segundo o avanço na ciência na elaboração de agenda de futuras pesquisas. Com relação à contribuição gerencial, as capacidades mapeadas podem ser utilizadas por gestores de instituições de ensino e contribuir para o melhor desempenho na transformação dos processos digitais das empresas deste setor.
Perceptions on the role of evidence: an English alcohol policy case study
Authors: Toner Paul , Lloyd Charlie , Thom Betsy , MacGregor Susanne , Godfrey Christine , Herring Rachel , Tchilingirian Jordan
Published: June 2022

This paper explores the competing influences which inform public health policy and describes the role that research evidence plays within the policy-making process. In particular it draws on a recent English alcohol policy case study to assess the role of evidence in informing policy and practice. Semi-structured interviews with key national, regional and local policy informants were transcribed and analysed thematically. A strong theme identified was that of the role of evidence. Findings are discussed in the context of competing views on what constitutes appropriate evidence for policy making.
Perceptions of gender equality and engaged fatherhood among young fathers: parenthood and the welfare state in Sweden and the UK
Authors: Andreasson Jesper , Tarrant Anna , Johansson Thomas , Ladlow Linzi
Published: June 2022

This article presents analyses from an international empirical study of young fatherhood in Sweden and the UK to interrogate how welfare contexts and family policies shape young fathers’ views of parenthood. Our analyses demonstrate that despite differences in constructions of young fatherhood, whereby young parenthood is problematised in UK family policy, more so than in Sweden, young fathers in both countries express an encouraging commitment to contemporary cultural imperatives for engaged fatherhood. However, differences in welfare and parental leave systems have a clear influence on the extent to which the young men in the respective countries fulfil their parental commitments and act as local agents of change in the wider social project of gender equality. We argue that while policy processes and discourses in support of young parenthood and gender equality are currently treated as disparate concerns, their articulations with one another may instead be seen as complementary and symbiotic.
COVID-19 and acute kidney injury in German hospitals 2020
Authors: Walendy Victor , Girndt Matthias , Greinert Daniel
Published: June 2022

Introduction

The SARS-CoV-2 pandemic is a major challenge for patients, healthcare professionals, and populations worldwide. While initial reporting focused mainly on lung involvement, the ongoing pandemic showed that multiple organs can be involved, and prognosis is largely influenced by multi-organ involvement. Our aim was to obtain nationwide retrospective population-based data on hospitalizations with COVID-19 and AKI in Germany.

Materials & methods

We performed a query of G-DRG data for the year 2020 via the Institute for the hospital remuneration system (Institut für das Entgeltsystem im Krankenhaus GmbH, InEK) data portal and therefore included hospitalizations with a secondary diagnosis of RT-PCR proven COVID-19 infection, aged over 15 years. We included hospitalizations with acute kidney injury (AKI) stages 1 to 3. Age-specific and age-standardized hospitalization and in-hospital mortality rates (ASR) per 100.000 person years were calculated, with the German population of 2011 as the standard.

Results

In 2020, there were 16.776.845 hospitalizations in German hospitals. We detected 154.170 hospitalizations with RT-PCR proven COVID-19 diagnosis. The age-standardized hospitalization rate for COVID-19 in Germany was 232,8 per 100.000 person years (95% CI 231,6–233,9). The highest proportion of hospitalizations associated with COVID-19 were in the age group over 80 years. AKI was diagnosed in 16.773 (10.9%) of the hospitalizations with COVID-19. The relative risk of AKI for males was 1,49 (95%CI 1,44–1,53) compared to females. Renal replacement therapy (RRT) was performed in 3.443 hospitalizations, 20.5% of the hospitalizations with AKI. For all hospitalizations with COVID-19, the in-hospital mortality amounted to 19.7% (n = 30.300). The relative risk for in-hospital mortality was 3,87 (95%CI 3,80–3,94) when AKI occurred. The age-standardized hospitalization rates for COVID-19 took a bimodal course during the observation period. The first peak occurred in April (ASR 23,95 per 100.000 person years (95%CI 23,58–24,33)), hospitalizations peaked again in November 2020 (72,82 per 100.000 person years (95%CI 72,17–73,48)). The standardized rate ratios (SRR) for AKI and AKI-related mortality with the overall ASR for COVID-19 hospitalizations in the denominator, decreased throughout the observation period and remained lower in autumn than they were in spring. In contrast to all COVID-19 hospitalizations, the SRR for overall mortality in COVID-19 hospitalizations diverged from hospitalizations with AKI in autumn 2020.

Discussion

Our study for the first time provides nationwide data on COVID-19 related hospitalizations and acute kidney injury in Germany in 2020. AKI was a relevant complication and associated with high mortality. We observed a less pronounced increase in the ASR for AKI-related mortality during autumn 2020. The proportion of AKI-related mortality in comparison to the overall mortality decreased throughout the course of the pandemic.
Demographic and generational determinants of Poles’ participation in the sharing economy: Findings from a survey data analysis
Authors: Warwas Izabela , Podgórniak-Krzykacz Aldona , Wiktorowicz Justyna , Górniak Joanna
Published: June 2022

The fast development of technologies in today’s world is accompanied by the mushrooming of digital platforms constituting the core of the ecosystem of sharing economy. This multifaceted phenomenon and its ever-increasing presence have become a subject of public interest and debate, as well as encouraging research and scientific discourse. The article presents the results of the first study of Poles’ participation in sharing economy derived from a questionnaire survey of a representative sample (n = 1000). The purpose of the study was to characterise Poles participating in the digital economy and to determine how they differ in the use of sharing platforms depending on their age group and generation. The analysis has shown that the rates of Poles participating in the digital economy are the smaller, the older the age group, and that a rising number of the users of digital economy solutions translates into greater acceptance of sharing platforms. Among the oldest Poles, 70% do not participate in the digital economy and as much as 80% in the sharing economy. The numbers sharply contrast with generations Z and Y that participate in the sharing economy almost without exception. The most popular of sharing services turned out to be accommodation reservation indicated by every third respondent.
Finding the infectious dose for COVID-19 by applying an airborne-transmission model to superspreader events
Authors: Prentiss Mara , Chu Arthur , Berggren Karl K.
Published: June 2022

We probed the transmission of COVID-19 by applying an airborne transmission model to five well-documented case studies—a Washington state church choir, a Korean call center, a Korean exercise class, and two different Chinese bus trips. For all events the likely index patients were pre-symptomatic or mildly symptomatic, which is when infective patients are most likely to interact with large groups of people. Applying the model to those events yields results that suggest the following: (1) transmission was airborne; (2) superspreading events do not require an index patient with an unusually high viral load; (3) the viral loads for all of the index patients were of the same order of magnitude and consistent with experimentally measured values for patients at the onset of symptoms, even though viral loads across the population vary by a factor of >108. In particular we used a Wells-Riley exposure model to calculate q, the total average number of infectious quanta inhaled by a person at the event. Given the q value for each event, the simple airborne transmission model was used to determined Sq, the rate at which the index patient exhaled infectious quanta and N0, the characteristic number of COVID-19 virions needed to induce infection. Despite the uncertainties in the values of some parameters of the superspreading events, all five events yielded (N0∼300–2,000 virions), which is similar to published values for influenza. Finally, this work describes the conditions under which similar methods can provide actionable information on the transmission of other viruses.
Combining DNA and HPTLC profiles to differentiate a pain relief herb, Mallotus repandus, from plants sharing the same common name, “Kho-Khlan”
Authors: Thongkhao Kannika , Tungphatthong Chayapol , Pichetkun Vipawee , Gaewtongliam Suthathip , Wiwatcharakornkul Worakorn , Sukrong Suchada
Published: June 2022

The pain relief formula “Ya Pa Som Kho-Khlan (YPSKK)” or “ยาผสมโคคลาน” in Thai is officially recorded in the Natural List of Essential Medicines (NLEM) of Thailand. The main component is Mallotus repandus (Willd.) Müll. Arg.; however, Anamirta cocculus (L.) Wight & Arn and Croton caudatus Gleiseler share the same common name: “Kho-Khlan”. Confused usage of A. cocculus or C. caudatus can have effects via toxicity or unsuccessful treatment. This study aimed to combine a high-performance thin-layer chromatography (HPTLC) technique and DNA barcoding coupled with high-resolution melting (Bar-HRM) to differentiate M. repandus from the other two species. The M. repandus extract exhibited a distinct HPTLC profile that could be used to differentiate it from the others. DNA barcodes of the rbcL, matK, ITS and psbA-trnH intergenic spacer regions of all the plants were established to assist HPTLC analysis. The rbcL region was selected for Bar-HRM analysis. PCR amplification was performed to obtain 102 bp amplicons encompassing nine polymorphic nucleotides. The amplicons were subjected to HRM analysis to obtain melting curve profiles. The melting temperatures (Tm) of authentic A. cocculus (A), C. caudatus (C) and M. repandus (M) were separated at 82.03±0.09°C, 80.93±0.04°C and 80.05±0.07°C, respectively. The protocol was applied to test crude drugs (CD1-6). The HPTLC profiles of CD2-6 showed distinct bands of M. repandus, while CD1 showed unclear band results. The Bar-HRM method was applied to assist the HPTLC and indicated that CD1 was C. caudatus. While ambiguous melting curves from the laboratory-made formulae were obtained, HPTLC analysis helped reveal distinct patterns for the identification of the plant species. The combination of HPTLC and Bar-HRM analysis could be a tool for confirming the identities of plant species sharing the same name, especially for those whose sources are multiple and difficult to identify by either chemical or DNA techniques.
Artificial intelligence solutions enabling sustainable agriculture: A bibliometric analysis
Authors: Bhagat Priya Rani , Naz Farheen , Magda Robert
Published: June 2022

There is a dearth of literature that provides a bibliometric analysis concerning the role of Artificial Intelligence (AI) in sustainable agriculture therefore this study attempts to fill this research gap and provides evidence from the studies conducted between 2000–2021 in this field of research. The study is a systematic bibliographic analysis of the 465 previous articles and reviews done between 2000–2021 in relation to the utilization of AI in sustainable methods of agriculture. The results of the study have been visualized and presented using the VOSviewer and Biblioshiny visualizer software. The results obtained post analysis indicate that, the amount of academic works published in the field of AI’s role in enabling sustainable agriculture increased significantly from 2018. Therefore, there is conclusive evidence that the growth trajectory shows a significant climb upwards. Geographically analysed, the country collaboration network highlights that most number of studies in the realm of this study originate from China, USA, India, Iran, France. The co-author network analysis results represent that there are multi-disciplinary collaborations and interactions between prominent authors from United States of America, China, United Kingdom and Germany. The final framework provided from this bibliometric study will help future researchers identify the key areas of interest in research of AI and sustainable agriculture and narrow down on the countries where prominent academic work is published to explore co-authorship opportunities.
Attitudes and practices of ophthalmology doctors in London (UK) on the importance of discussing work as a clinical outcome with patients during consultations: A cross sectional survey
Authors: Kuncewicz Katherine , Schiff Isabelle , Liszka Jaroslaw , Akinfie Sheni , McLurcan Nadia , Madan Ira , Naleem Shairana , Parsons Vaughan
Published: June 2022

Background

Limited research suggests that non-occupational health doctors rarely discuss occupation with their patients. There is a gap in research regarding the attitudes and practices of doctors towards discussing patient occupation and return to work. The aim of this work was to explore the attitudes of ophthalmology doctors towards work as a clinical outcome and assess the need for occupational health training among participants (doctors).

Methods

A cross-sectional survey among doctors working in ophthalmology in two London teaching hospitals. The survey focused on the attitudes of doctors towards ‘work’ as a clinical outcome, their practices of asking patients about occupation, their perceived level of competency in this area of clinical practice and the level of training doctors had received in this field. Descriptive data analysis was undertaken and results presented as frequencies and proportions.

Results

The response rate was 30/72 (42%). Approximately a quarter (8/30;27%) of doctors ‘always’ discussed return to work during care planning whilst the majority (25/30;87%) of doctors agreed or strongly agreed that this should always be the case. Over half of the doctors had received no formal OH training on how to discuss or assess the impact of health on work and only 17/30 (57%) considered themselves competent in discussing these work outcomes with patients. Over half agreed that additional training would be useful, with the majority believing that it would be most useful at all stages of medical training.

Conclusion

We found the majority of ophthalmology doctors regard ‘return to work’ as an important clinical outcome yet most do not routinely discuss work outcomes with patients to inform care planning. Majority of doctors lack training in how to discuss issues relating to work and would benefit from additional OH training.
Causality of anthropometric markers associated with polycystic ovarian syndrome: Findings of a Mendelian randomization study
Authors: De Silva Kushan , Demmer Ryan T. , Jönsson Daniel , Mousa Aya , Teede Helena , Forbes Andrew , Enticott Joanne
Published: June 2022

Introduction

Using body mass index (BMI) as a proxy, previous Mendelian randomization (MR) studies found total causal effects of general obesity on polycystic ovarian syndrome (PCOS). Hitherto, total and direct causal effects of general- and central obesity on PCOS have not been comprehensively analyzed.

Objectives

To investigate the causality of central- and general obesity on PCOS using surrogate anthropometric markers.

Methods

Summary GWAS data of female-only, large-sample cohorts of European ancestry were retrieved for anthropometric markers of central obesity (waist circumference (WC), hip circumference (HC), waist-to-hip ratio (WHR)) and general obesity (BMI and its constituent variables–weight and height), from the IEU Open GWAS Project. As the outcome, we acquired summary data from a large-sample GWAS (118870 samples; 642 cases and 118228 controls) within the FinnGen cohort. Total causal effects were assessed via univariable two-sample Mendelian randomization (2SMR). Genetic architectures underlying causal associations were explored. Direct causal effects were analyzed by multivariable MR modelling.

Results

Instrumental variables demonstrated no weak instrument bias (F > 10). Four anthropometric exposures, namely, weight (2.69–77.05), BMI (OR: 2.90–4.06), WC (OR: 6.22–20.27), and HC (OR: 6.22–20.27) demonstrated total causal effects as per univariable 2SMR models. We uncovered shared and non-shared genetic architectures underlying causal associations. Direct causal effects of WC and HC on PCOS were revealed by two multivariable MR models containing exclusively the anthropometric markers of central obesity. Other multivariable MR models containing anthropometric markers of both central- and general obesity showed no direct causal effects on PCOS.

Conclusions

Both and general- and central obesity yield total causal effects on PCOS. Findings also indicated potential direct causal effects of normal weight-central obesity and more complex causal mechanisms when both central- and general obesity are present. Results underscore the importance of addressing both central- and general obesity for optimizing PCOS care.
Traditional sheep breeding practices under agroforestry system of Gedeo zone, Southern Ethiopia
Authors: Tezera Biruh Tesfahun , Engidashet Demeke Haile
Published: June 2022

The study was undertaken in Gedeo zone with the aim to identify traditional sheep breeding practices. Three potential districts (Yirgachefe, Bule and Gedeb) were purposely selected from Gedeo zone. A total of 180 smallholder sheep farmers were selected at random to complete a structured questionnaire that had been pretested. A pairwise ranking tool was used to prioritize ranked data during focus group discussion. Descriptive statistics were generated using SPSS version 26, while indices were computed for the ranked data. Mating happens because most farmers in Gedeo zone (80%) own breeding rams that are mixed and run with ewe flocks. Fifty-two percent of farmers were certain that their breeding rams mate with neighboring ewes. Nearly 70% of farmers prevented unwanted sheep breeding in their flocks by castrating or isolating undesirable rams from the ewe flock. Undesired or old breeding rams were replaced either from the same flock (58.9%) or purchased from local markets (41.1%). Breeding flock selection was common in Gedeo zone, with 97.2% of farmers selecting breeding rams and 93.3% of farmers selecting breeding ewes. Genotype (Index = 0.26) and body conformation (Index = 0.20) were the primary and secondary criteria used to select breeding ewes. Likewise, confirmation (Index = 0.25), genotype (Index = 0.24) and lamb growth rate (Index = 0.19) were the top three criteria when selecting breeding rams. Approximately three-quarters of interviewed farmers culled sheep due to poor body condition (31.8%), old age (28.6%), sickness (22.7%) and sterility (15.6%). Castration of rams was more common in Gedeb (58.3%) and Yirgachefe (55%) districts, and it was done for fattening, controlling unwanted breeding, and improving temperament. The mean selection and castration age of breeding rams were 13.18 and 30.72 months. In general, sheep breeding strategies for Gedeo zone should take into account section preferences and basic traditional sheep breeding practices.
Determinants of wasting among children aged 6–59 months in Wonago woreda, south Ethiopia. A facility-based unmatched case-control study
Authors: Habtamu Endashaw , Chilo Desalegn , Desalegn Defaru
Published: June 2022

Background

Wasting continued to threaten the lives of 52 million (7.7%) under-five children globally. Sub-Saharan Africa accounts for one-third of all wasted children globally, and Ethiopia is among the countries with the highest magnitude of Wasting in the region. Despite, the little decrement in the prevalence of other forms of malnutrition (stunting and underweight), the burden of wasting remains the same in the country. Gedeo zone is among those with a high prevalence of under-five wasting.

Objective

To identify determinants of wasting among children aged 6–59 months in Wonago Woreda, 2018.

Methods

A facility-based unmatched case-control study was conducted from May 11 to July 21/2018. A total of 356 (119 cases and 237 controls) mothers/caregivers of under-five children who visited the Wonago woreda public health facilities were included in the study using systematic random sampling. Data were collected using a structured questionnaire and anthropometric measurement. Descriptive analysis was used to describe data. Binary logistic regression was used to identify determinants of wasting among children aged 6–59 months. Variables with p-value < 0.25 in bi-variate analysis entered to multivariate analysis. Those variables with a p-value less than 0.05 during the multivariate regression were considered significant.

Results

Determinants which found to have an association with wasting in this study were; maternal illiteracy [AOR = 2.48, 95% CI (1.11, 5.53)] family size <3 [AOR = 0.16, 95% CI (0.05, 0.50)] wealth index [AOR = 2.41, 95% CI (1.07, 5.46)] exclusive breastfeeding in the first 6 months [AOR = 2.71, 95% CI (1.15, 6.40)] dietary diversity [AOR = 5.52, 95% CI (2.06, 14.76)] and children been sick in the last 2 weeks [AOR = 4.36, 95% CI (2.21, 8.61)].

Conclusion and recommendations

Determinants identified were maternal education, family size, wealth index, and exclusive breastfeeding, dietary diversity, and morbidity history of a child in the last 2 weeks. To reduce childhood wasting, due emphasis should be given to empowering women and improving the knowledge and practice of parents on appropriate infant and young child-caring practices.
Healthcare worker-based opportunistic screening for familial hypercholesterolemia in a low-resource setting
Authors: Sharma Sonali , Khudiwal Ashish , Bhardwaj Sonal , Chaturvedi Hemant , Gupta Rajeev
Published: June 2022

Background & objective

Heterozygous familial hypercholesterolemia (FHeH) is important risk factor for premature coronary artery disease (CAD). Strategies for its diagnosis and prevalence have not been well studied in India. We performed healthcare worker-based opportunistic screening to assess feasibility for determining its prevalence.

Methods

A healthcare worker was trained in use of Dutch Lipid Clinic Network (DLCN) criteria for diagnosis of FHeH. Successive eligible individuals (n = 3000 of 3450 screened) presenting to biochemistry laboratories of two hospitals for blood lipid measurements were evaluated for FHeH. Cascade screening or genetic studies were not performed. Descriptive statistics are reported.

Results

We included 2549 participants (men 1870, women 679) not on statin therapy. Health worker screened 25–30 individuals/day in 6–10 minutes each. The mean age was 46.2±11y. Variables of DLCN criteria were more in women vs men: family history 51.1 vs 35.6%, past CAD 48.2 vs 20.1%, arcus cornealis 1.1 vs 0.3%, tendon xanthoma 0.3 vs 0.1%, and LDL cholesterol 190–249 mg/dl in 8.5 vs 2.4%, 250–329 mg/dl in 0.7 vs 0% and ≥330 mg/dl in 0.3 vs 0% (p<0.01). Definite FHeH (DLCN score >8) was in 15 (0.59%, frequency 1:170) and probable FHeH (score 6–8) in 87 (3.4%, frequency 1:29). The prevalence was significantly greater in women, age <50y and in those with hypertension, diabetes and known CAD.

Conclusions

Healthcare worker-led opportunistic screening for diagnosis of FHeH using DLCN criteria is feasible in low-resource settings. The results show significant prevalence of clinically detected definite and probable FHeH in the population studied.