bluuebunny/crossref_metadata_2025 huggingface dataset:
Automatic quantification of tumor-stroma ratio as a prognostic marker for pancreatic cancer
Authors: Vendittelli Pierpaolo , Bokhorst John-Melle , Smeets Esther M. M. , Kryklyva Valentyna , Brosens Lodewijk A. A. , Verbeke Caroline , Litjens Geert
Published: May 2024

Purpose

This study aims to introduce an innovative multi-step pipeline for automatic tumor-stroma ratio (TSR) quantification as a potential prognostic marker for pancreatic cancer, addressing the limitations of existing staging systems and the lack of commonly used prognostic biomarkers.

Methods

The proposed approach involves a deep-learning-based method for the automatic segmentation of tumor epithelial cells, tumor bulk, and stroma from whole-slide images (WSIs). Models were trained using five-fold cross-validation and evaluated on an independent external test set. TSR was computed based on the segmented components. Additionally, TSR’s predictive value for six-month survival on the independent external dataset was assessed.

Results

Median Dice (inter-quartile range (IQR)) of 0.751(0.15) and 0.726(0.25) for tumor epithelium segmentation on internal and external test sets, respectively. Median Dice of 0.76(0.11) and 0.863(0.17) for tumor bulk segmentation on internal and external test sets, respectively. TSR was evaluated as an independent prognostic marker, demonstrating a cross-validation AUC of 0.61±0.12 for predicting six-month survival on the external dataset.

Conclusion

Our pipeline for automatic TSR quantification offers promising potential as a prognostic marker for pancreatic cancer. The results underscore the feasibility of computational biomarker discovery in enhancing patient outcome prediction, thus contributing to personalized patient management.
Low-frequency transmission and persistence of antimicrobial-resistant bacteria and genes from livestock to agricultural soil and crops through compost application
Authors: Fukuda Akira , Suzuki Masato , Makita Kohei , Usui Masaru
Published: May 2024

Livestock excrement is composted and applied to agricultural soils. If composts contain antimicrobial-resistant bacteria (ARB), they may spread to the soil and contaminate cultivated crops. Therefore, we investigated the degree of transmission of ARB and related antimicrobial resistance genes (ARGs) and, as well as clonal transmission of ARB from livestock to soil and crops through composting. This study was conducted at Rakuno Gakuen University farm in Hokkaido, Japan. Samples of cattle feces, solid and liquid composts, agricultural soil, and crops were collected. The abundance of Escherichia coli, coliforms, β-lactam-resistant E. coli, and β-lactam-resistant coliforms, as well as the copy numbers of ARG (specifically the bla gene related to β-lactam-resistant bacteria), were assessed using qPCR through colony counts on CHROMagar ECC with or without ampicillin, respectively, 160 days after compost application. After the application of the compost to the soil, there was an initial increase in E. coli and coliform numbers, followed by a subsequent decrease over time. This trend was also observed in the copy numbers of the bla gene. In the soil, 5.0 CFU g-1 E. coli was detected on day 0 (the day post-compost application), and then, E. coli was not quantified on 60 days post-application. Through phylogenetic analysis involving single nucleotide polymorphisms (SNPs) and using whole-genome sequencing, it was discovered that clonal blaCTX-M-positive E. coli and blaTEM-positive Escherichia fergusonii were present in cattle feces, liquid compost, and soil on day 0 as well as 7 days post-application. This showed that livestock-derived ARB were transmitted from compost to soil and persisted for at least 7 days in soil. These findings indicate a potential low-level transmission of livestock-associated bacteria to agricultural soil through composts was observed at low frequency, dissemination was detected. Therefore, decreasing ARB abundance during composting is important for public health.
Effect of phosphate group on remineralization of early enamel caries regulated by amelogenin peptide
Authors: Zhao Hualei , Zhang Qun , Chu Jinpu
Published: May 2024

Objective

To show the effect of the phosphate group on the remineralization process of early enamel caries mediated by amelogenin peptide.

Methods

Freshly extracted, completed, and crack-free bovine teeth were used to create artificial early enamel caries, which were randomly divided into four groups: Group A: fluorination remineralized solution treatment group; Group B: pure remineralized solution treatment group. Group C: 100 g/ml recombinant Amelogenin peptide remineralized solution treatment group (with single phosphate group on N-terminus); Group D: 100 g/ml non-phosphorylated recombinant Amelogenin peptide remineralized solution treatment group (without single phosphate group on N-terminus). For 12 days, fresh remineralized solutions were replaced daily. Transverse microradiography (TMR) was used after remineralization to determine mineral loss and demineralization depth before and after each sample’s remineralization. Each sample’s depth of remineralization and mineral acquisition were then determined.

Results

The recombinant amelogenin peptide group significantly outperformed the non-phosphorylated amelogenin peptide group in terms of mineral acquisition and mineralization depth (P<0.05).

Conclusions

The recombinant Amelogenin’s solitary phosphate group at the N-terminus helps recombinant Amelogenin to encourage the remineralization process of early enamel caries.
Investigation on damage evolution mechanism of various FRP strengthened concrete subjected to chemical-freeze-thaw coupling erosion
Authors: Li Wei , Wang Dayang , Xu Wenyuan , Ji Yongcheng
Published: May 2024

The corrosion resistance of FRP-reinforced ordinary concrete members under the combined action of harsh environments (i.e., alkaline or acidic solutions, salt solutions) and freeze-thaw cycles is still unclear. To study the mechanical and apparent deterioration of carbon/basalt/glass/aramid fiber cloth reinforced concrete under chemical and freeze-thaw coupling. Plain concrete blocks and FRP-bonded concrete blocks were fabricated. The tensile properties of the FRP sheet and epoxy resin sheet before and after chemical freezing, the compressive strength of the FRP reinforced test block, and the bending capacity of the prismatic test block pasted with FRP on the prefabricated crack side were tested. The deterioration mechanism of the test block was analyzed through the change of surface photos. Based on the experimental data, the Lam-Teng constitutive model of concrete reinforced by alkali-freeze coupling FRP is modified. The results indicate that, in terms of apparent properties, with the increase in the duration of chemical freeze-thaw erosion, the surface of epoxy resin sheets exhibits an increase in pores, along with the emergence of small cracks and wrinkles. The texture of FRP sheets becomes blurred, and cracks and wrinkles appear on the surface. In terms of failure modes, as the number of chemical coupling erosion cycles increases, the location of failure in epoxy resin sheets becomes uncertain, and the failure plane tilts towards the direction of the applied load. The failure mode of FRP sheets remains unchanged. However, the bonding strength between FRP sheets and concrete decreases, resulting in a weakened reinforcement effect. In terms of mechanical properties, FRP sheets undergo the most severe degradation in the coupled environment of acid freeze-thaw cycles. Among them, GFRP experiences the largest degradation in tensile strength, reaching up to 30.17%. In terms of tensile performance, the sheets rank from highest to lowest as follows: CFRP, BFRP, AFRP, and GFRP.As the duration of chemical freeze-coupled erosion increases, the loss rate of compressive strength for specimens bonded with CFRP is the smallest (9.62% in salt freeze-thaw environment), while the loss rate of bearing capacity is higher for specimens reinforced with GFRP (33.8% in acid freeze-thaw environment). In contrast, the loss rate of bearing capacity is lower for specimens reinforced with CFRP (13.6% in salt freeze-thaw environment), but still higher for specimens reinforced with GFRP (25.8% in acid freeze-thaw environment).
Uncertainty quantification and sensitivity analysis of neuron models with ion concentration dynamics
Authors: Signorelli Letizia , Manzoni Andrea , Sætra Marte J.
Published: May 2024

This paper provides a comprehensive and computationally efficient case study for uncertainty quantification (UQ) and global sensitivity analysis (GSA) in a neuron model incorporating ion concentration dynamics. We address how challenges with UQ and GSA in this context can be approached and solved, including challenges related to computational cost, parameters affecting the system’s resting state, and the presence of both fast and slow dynamics. Specifically, we analyze the electrodiffusive neuron-extracellular-glia (edNEG) model, which captures electrical potentials, ion concentrations (Na+, K+, Ca2+, and Cl−), and volume changes across six compartments. Our methodology includes a UQ procedure assessing the model’s reliability and susceptibility to input uncertainty and a variance-based GSA identifying the most influential input parameters. To mitigate computational costs, we employ surrogate modeling techniques, optimized using efficient numerical integration methods. We propose a strategy for isolating parameters affecting the resting state and analyze the edNEG model dynamics under both physiological and pathological conditions. The influence of uncertain parameters on model outputs, particularly during spiking dynamics, is systematically explored. Rapid dynamics of membrane potentials necessitate a focus on informative spiking features, while slower variations in ion concentrations allow a meaningful study at each time point. Our study offers valuable guidelines for future UQ and GSA investigations on neuron models with ion concentration dynamics, contributing to the broader application of such models in computational neuroscience.
The effects of digital economy development on social insurance funds revenue: Evidence from China
Authors: Pan Xiaoqing , Li Bo , Wu Jing
Published: May 2024

China has experienced rapid development in the digital economy. Using data from 30 provinces in China between 2011 and 2017, this paper constructs a two-way fixed effects model to study the effects and mechanisms of the digital economy development on social insurance funds revenue. An increase of one unit in digital economy development led to a 0.56% increase in basic endowment insurance funds revenue and a 0.33% increase in basic health insurance funds revenue. The digital economy increased the social insurance funds revenue by promoting employment and increasing income. Furthermore, the effects of digital economic development on social insurance funds revenue were heterogeneous for different levels of economic development and urbanization. The conclusions stood after robustness tests by changing the method of weighting the digital economy indicators and using instrumental variables. This paper confirmed the positive role of the development of the digital economy in increasing the revenue of social insurance funds from the perspective of quantitative research and explored the mechanisms in depth. In order to increase social insurance funds revenue, it is essential to accelerate the development of the digital economy, especially in regions with lower economic development and urbanization, and to address the needs of the technically unemployed and those engaged in flexible employment.
A progressive approach to multi-criteria group decision-making: N-bipolar hypersoft topology perspective
Authors: Musa Sagvan Y. , Asaad Baravan A.
Published: May 2024

This paper investigates N-bipolar hypersoft topology (N-BHST), a novel extension of both the well-established N-hypersoft topology (N-HST) and hypersoft topology (HST). Deviating significantly from its precursor, the N-bipolar hypersoft (N-BHS) set, N-BHST introduces a multi-opinion approach to decision-making, augmenting robustness and adaptability. This innovative framework addresses identified limitations in N-bipolar soft topology (N-BST), especially in managing multi-argument approximate functions. The study analyzes various operators (closure, interior, exterior, and boundary) within the N-BHST framework, elucidating their interrelationships. Additionally, an examination is carried out on the enhancement of multi-criteria group decision-making (MCGDM) using N-BHST, setting it apart from existing models. A numerical example is presented to illustrate its application in real-world decision scenarios.
Analysis of aggregation profile of glucagon using SEC-HPLC and FFF-MALS methods
Authors: Bao Zhongli , Cheng Ya-Chi , Luo Mary Ziping , Zhang Jack Yongfeng
Published: May 2024

Recently, the first generic glucagon for injection was approved for the treatment of severe hypoglycemia. Unlike its brand name recombinant glucagon, the generic glucagon is synthetic. Since glucagon has a high propensity to form aggregates in solution, it is essential to assess the aggregation profile of the synthetic glucagon compared to the recombinant glucagon. In this study, two robust separation methods, size-exclusion chromatography (SEC-HPLC) and field-flow fractionation coupled with a multi-angle light scattering detector (FFF-MALS), were employed to characterize generic and brand glucagon aggregation in six lots (three newly released, three expired). The presence of aggregation in samples was determined from the generated chromatograms and analyzed. The study showed that both products have comparable aggregation profiles. The SEC-HPLC demonstrated that in both glucagon versions, the expired lots had a higher percentage of dimers than the newly released lots, but even at expiration, the amount was negligible (∼0.1%). The FFF-MALS method did not detect any dimers or higher molecular weight aggregates. Further evaluation of the detection limit found that FFF-MALS was unable to detect aggregates at amounts lower than 0.5% of total glucagon. The negligible amounts of dimer detected in the generic and brand glucagon indicate that both versions are physically stable and are not prone to aggregation under clinically relevant conditions.
Combater a fome oculta
Authors: Aboim Pires Leonardo
Published: May 2024

Como é que os médicos observavam e analisavam a alimentação dos portugueses durante o século XX? Para responder a essa questão, neste artigo revisitamos a presença dos regimes alimentares no pensamento médico, especialmente durante o Estado Novo. Concluímos que as ideias sobre a alimentação e a nutrição se enquadravam numa lógica de promoção de melhoria da sociedade, em que os médicos surgiam como agentes privilegiados na correção de condutas que eram entendidas como prejudiciais. A construção da sua identidade profissional e intervenção social era assim feita de forma a reconfigurar padrões quotidianos, numa abordagem que ultrapassava classes e regiões, compondo uma noção integradora do país.
Origens da sensibilidade devocional da narrativa de Fátima
Authors: Eduardo Franco José , Pinto Porfírio
Published: May 2024

A narrativa de Fátima é profundamente devedora das correntes modernas de espiritualidade mariana, ou cristológico-mariana. A Senhora que apareceu em Fátima, na última das suas aparições, revelou-se como «a Senhora do Rosário». Esta invocação mariana, que se afirmou nos anos subsequentes à conclusão do concílio de Trento (sobretudo depois da Batalha de Lepanto, em 1571), era particularmente venerada pelos Pastorinhos na sua paróquia de Fátima. No entanto, nas conversas destes com a Senhora vestida de branco, «mais brilhante que o sol» (cf. Ct 6, 10; Ap 12, 1), sobressai a doutrina reparadora do Imaculado Coração de Maria, bem como a sombra protetora da Mãezinha do Céu, a «Mãe de misericórdia» da tradição monástica. São estas duas sensibilidades modernas que constituirão o objeto da breve abordagem apresentada neste nosso ensaio.
De Roma a Portugal, do Império ao Reino: uma viagem de 1500 anos pela região de Coimbra
Authors: Trindade Luísa , Carvalho Pedro C.
Published: May 2024

Contar uma história à escala de 22 concelhos e de 15 séculos é uma odisseia; uma aventura digna de ser acompanhada por registos do melhor escrivão da corte.
Fazê-lo, partiu da firme convicção de que a história da região de Coimbra merecia ser, de forma inédita, contada segundo uma perspetiva contínua, do ponto de vista físico e temporal. Por um lado, porque Coimbra, e a região envolvente, foi território central em diferentes episódios, capitais e
sucedâneos, de uma história que é agora lida com a sua fluidez natural. Por outro, porque a quantidade e diversidade do património edificado que hoje ainda podemos visitar justifica que ele seja enquadrado em rede, a fim de que a sua importância seja efetivamente compreendida num quadro de ação maior do que a simples circunstância do território
onde foi outrora erguido.
A bálna queer teste
Authors: Gerevich András
Published: May 2024

Darren Aronofsky A bálna című filmje sok szempontból a queer film konvencióinak antitézise, sőt, nevezhetjük anti-queer filmnek is. Dolgozatom első felében a filmet queer szemszögből elemezem, a második részében feltérképezem a film angolnyelvű recepcióját, majd végül kifejtem, hogy miért nem sorolható a film a queer kánonba, amit a filmes kritika sem tesz meg. A főszereplő, Charlie, kudarcot vallott, mint férj és apa, mint queer élettárs és mint férfi egyaránt, egyik szerepet sem tudta teljesen magáévá tenni, és a különböző szerepeket nem sikerült integrálnia. Életének homoszexuális és heteroszexuális szakaszait időben és térben is elválasztja, a kudarc és a gyász szégyenhez és depresszióhoz vezet, az pedig kényszeres evéshez és megalázottsághoz. Charlie öngyilkos lesz: lassan halálba eszi magát. Charlie karakterén és történetén keresztül a kövérség és a nemi orientáció interszekcionális elemzését adom: a film narratíváját meghatározó túlsúly problematikus patologizálását, az internalizált homofóbiát, a queer szégyent, a fallosz nélküli, deszexualizált test regresszív állapotának traumáját, és a heteronormativitáshoz való visszatérés vágyát veszem sorra. A filmet a kritika többnyire fenntartásokkal vagy kimondottan negatívan fogadta, mert mind a kövérséget, mind a queerséget problematikusan, negatív klisékkel és sztereotipikus jegyekkel ábrázolta. Nem csak Charlie vall kudarcot, hanem a rendező, Aronofsky is. Dolgozatomban azt probálom körbejárni, hogy a film miért nem tud megfelelni a kritika és a közönség elvárásainak, és miért nincs helye a queer kánonban.
Likantrópiák
Authors: László Borbála
Published: May 2024

A tanulmány a Farkasok népe (Wolfwalkers, 2020) című animációs filmben megfigyelhető fiktív és mediális átváltozások poszthumanista olvasatát nyújtja. Az elemzés szerint a fiktív átváltozások a film főszereplőjét, a fiatal Robynt érintik, aki vadász édesapjával Írországba utazik, hogy segítsen elpusztítani az utolsó helyi farkas falkát. A kalandvágyó lány azonban összebarátkozik egy ősi farkasember-törzs leszármazottjával, Mebh-bel, majd egy (véletlen) farkasharapás útján ő maga is képessé válik arra, hogy éjszakánként farkas alakot öltsön. A tanulmány Robynt olyan szimpoetikus entitásként értelmezi, mely a humanista binárisok és hierarchiák helyett az ember és az állat, a természet és a civilizáció, valamint a férfi és a női lét közötti fluiditás elfogadásával, az ezekkel való kapcsolódási folyamatokban jön létre. A tanulmány a cselekmény szintjén a főszereplőben zajló átváltozásokat, míg a film vizuális szintjén a mediális átváltozásokat vizsgálja, melyek meghatározó szerepet játszanak a film által megjelenített poszthumán szubjektum és világkép kialakításában. Robyn jellem- és világképformálódását a film különböző képalkotási módszerek (kézi és digitális animáció), animációs irányzatok (európai lineáris-figurális és populáris amerikai irányzatok), művészettörténeti inspirációk (petroglifák; ősi kelta, amerikai indián, és európai művészet; középkori kódex- és faliszőnyegképek; modernista és szecessziós művészet), eljárás-imitációk (vízfesték és fametszet), valamint vonalak, formák, és színvilágok hibridizálásával teremti meg. Ezen megoldások miatt maga a médium is szimpoetikusnak tekinthető.
Preparation of light fraction silicate filer after the mining for the base layers’ road construction
Authors: Jančíková Andrea , Dvořák Karel , Ravaszová Simona
Published: May 2024

The article main objective was eco-innovation in the field of utilization and creation of a complex waste-free technology for the separation of components during ore extraction with subsequent processing, recovery of mine tailings in combination with available energy. The article deals with the topic of production and preparation of base layers for road construction in the form of silicate filer after separation of ore mining. The chemical and mineralogical composition on the fine fraction of the separated tailings was carried out by XRD analysis, filer particle size followed up by Laser Granulometry and other comprehensive measurements and the development of basic parameters by individual standard tests. The results determined on the functional sample demonstrated that it is possible to create an almost completely waste-free technology in the field of separation of components during ore extraction and its subsequent processing and use for the base layers of linear road construction.
Self-compacting concrete with reduced formwork pressures
Authors: Němeček Jiří , Trávníček Pavel , Tichý Jan
Published: May 2024

Self-compacting concrete (SCC) is normally characterized with high pressures exerted on the formwork during casting. The pressures can easily exceed bearing capacity of a regular formwork when casting a high structural member in one step. The contribution shows new ways of reducing the pressures using mineral additives based on calcinated clay minerals and clay nanoparticles whose addition together with interrupted casting process leads to a substantial reduction of the formwork pressures. Short interruptions in the casting lead to microstructural changes and flocculation, thixotropy and early strength evolution. The positive effects are studied systematically in microstructural studies performed on modified cement pastes using microscopy and viscosimetry. Rheological behavior of standard SCCs is improved towards thixotropy of the mixture by using the mineral additives. The newly developed recipes are tested on SCCs used on real construction sites. Examples of their practical utilization and on-site measurements show on up to 50 % pressure reductions in enriched SCCs compared to ordinary SCCs.
Structural health monitoring of construction
Authors: Niedoba Jakub
Published: May 2024

The paper is concerned with the possibilities of long-term monitoring of constructions using modern wireless sensors and systems. There are currently many constructions under long-term monitoring performed by modern sensors. The monitoring enables an assessment of the current health of the construction or it can be used to recalculate and adjust the BMI models and subsequently evaluate the static and dynamic resistance of the construction. The sensors and systems installed enable the detection of hidden defects or newly emerging failures and damage. Using the results obtained from the monitoring of the construction, it is possible to predict and carry out a timely repair or maintenance of the construction, which will ultimately decrease the financial and time-related costs, ensure greater safety and prolong its lifetime and resistance.
Terapias asistidas con animales en el ámbito ambulatorio
Authors: Degiorgio Laura , Fleitas Camila , Maguiña Coltrinari Pamela , Rodríguez María de los Milagros , Fleitas Sergio , Sarquis Juan Andrés
Published: May 2024

La relación con los animales ha cambiado a lo largo de la historia de la humanidad. Un número creciente de investigaciones proponen que este vínculo es potencialmente terapéutico para pacientes con diferentes discapacidades intelectuales. A pesar de ello, no se encuentra un consenso entre el tipo de animales más utilizados, tipo de pacientes y beneficios esperables de estas terapias. En este marco, se realizó una revisión exhaustiva con el fin de relevar el tipo de pacientes más frecuentes con diferentes discapacidades intelectuales definidas en Diagnostic and Statistical Manual of Mental Disorders. Para ello se revisó el grado de discapacidad de los participantes, tipo de animales utilizados, método utilizado para valorar la eficacia de la terapia, rango etario, sexo y tipo de instituciones que lo llevan a cabo. Se revisaron más de 250 trabajos, la mayoría de los animales que colaboran como coterapeutas son considerados domésticos o de granja. Se encontró que los pacientes con parálisis cerebral es la patología más frecuente en los estudios de la Terapia con animales. Pareciera ser que estas terapias con asistencia de animales son de gran importancia para la recuperación de pacientes con discapacidades intelectuales, aunque la mayoría de estos trabajos carece de mediciones cuantitativas en aspectos fisiológicos, bioquímicos y psicológicos. Se requiere de una metodología clara, unificada y un equipo transdisciplinario de profesionales de la salud para poder conocer los beneficios en la salud de las Terapias con animales.
Pensar el cáncer de cuello de útero
Authors: Espinoza Marisa Isabel
Published: May 2024

El cáncer de cuello de útero (CCU) continúa siendo una causa preponderante de mortalidad en las mujeres a nivel mundial. Las tasas de mortalidad expresan una tendencia positiva para la Argentina y la provincia de Santa Fe. Si bien la patología es bien conocida y posee varios momentos de intervención desde la prevención primaria, secundaria y terciaria, su eficacia pareciera resultar limitada. Se realizó un análisis crítico genealógico de los paradigmas epistemológicos implicados en las perspectivas de los procesos de salud-enfermedad-atención/prevención y sus puntos de acción sobre el CCU. Se postula que la lente con la que se mira la enfermedad no logra salirse del fundamento reduccionista, atomizado y determinista de la salud, a pesar de su propuesta más sofisticada: los determinantes sociales de la salud. Este modelo, tras la pretensión de un enfoque integral, en tanto epidemiología del riesgo restringe la mirada a la punta del iceberg y se hace funcional a las formas civilizatorias que promueven las desigualdades. La epidemiología crítica propone el concepto de la determinación social de la salud visibilizando la relación entre estructura social, salud y el devenir de la reproducción social según estilo de vida. Así el CCU será el producto de un proceso de embodiment tras la expresión en el cuerpo de condiciones destructivas o deteriorantes marcadas por las inequidades de género, etnia y clase social. Surge desde este análisis el ejemplo de la autotoma de test de HPV como forma de resistencia y apuesta contrahegemónica emancipadora al modelo pragmático-funcionalista de la salud.
The Correlation Between Behavioral and Psychological Factors with Booster Immunization Adherence for Children Aged <24 Months
Authors: Sriatmi Ayun , Martini Martini , Patriajati Sutopo , Budiyono Budiyono
Published: May 2024

Background: Immunization status is considered complete when children receive all antigens types as recommended, including booster immunization, ensuring optimal protection. The high level of non-adherence is the main obstacle to immunization programs, further added by the fact that the number of children who receive partial or no immunization remains high. This study aims to analyze the correlation between behavioral and psychological factors with booster immunization adherence in children aged <24 months.Method: A quantitative study with a cross-sectional approach. The population consists of parents with children aged 18-23 months, totaling a sample of 522 children. The data were collected through interviews using structured questionnaires, and observations using MCH-Book to measure booster immunization adherence. The collected data was analyzed through univariate, bivariate, and multivariate approaches with multiple logistic regression tests to identify the dominant variables.Results: Only 25.9% of children received two types of recommended booster vaccines (DPT/HB/HiB-4 and MR-2). Partially, behavioral factors that correlate with booster immunization adherence are knowledge, attitudes, and perceptions about multiple injections, while psychological factors that correlate are motivation and basic immunization status. Experience with previous basic immunization status is the most dominant factor influencing booster immunization adherence. The fear of disease infection and trust in healthcare providers are the keys to a successful immunization. Need to increase motivation through strengthening literacy and improving access to and health service system to reduce hesitation about, distrust, and refusal of immunization, while also providing a positive immunization experience.
Vom innerjüdischen Appell zur öffentlichen Kampagne. Joel Bril Löwes Sendschreiben an die Brüderschaften und der Beerdigungsfristenstreit in Breslau, 1793–1800
Authors: Lohmann Uta
Published: May 2024

The danger of burying only apparently dead bodies when following the Jewish custom to bury the deceased within a day was a hotly debated topic in the eighteenth century. Joel Bril Löwe participated in this debate with an open letter to the burial brotherhoods of all Jewish communities. The article reconstructs the dispute between the traditionalists, who argued for the Jewish custom of immediate burial, and the modernizers, who argued for its abandonment. Despite Löwe’s efforts to mediate between the fronts and to convince everyone to allow three days until the funeral were not successful, the dispute escalated, particularly in Breslau. In a number of German and Hebrew journals, Jewish supporters of the three-day limit ran campaigns, some of them rather aggressive, which led to the founding of new burial societies and attracted the attention of the Prussian authorities. The practice of early burial could only be brought to an end by state order.
Hebräische Autorennetzwerke in der Breslauer Haskala. Mordechai Roch (1763–1825) und seine nachgelassene Manuskriptsammlung
Authors: Naimark-Goldberg Natalie
Published: May 2024

While the use of Hebrew was much in decline in most parts of Germany by the end of the eighteenth century, a considerable number of modern Hebrew texts were being published in Breslau with the specific goal of promoting and maintaining the relevance of Hebrew. The article presents a group portrait of the authors who promoted this consolidation of Hebrew study and modern Hebrew writing. It focuses on Mordechai Roch, a lesser-known author whose maskilic activity spanned more than three decades and thus linked the early attempts of the 1790s with a new flowering of Hebrew writing in the 1810s.
The impact of diffusion and perfusion-weighted imaging on glioma grading
Authors: Dinh Hieu Nguyen , Duy Hung Nguyen , Thanh Dung Le , Ngoc Anh Nguyen , Minh Duc Nguyen
Published: May 2024

Objectives

Determining the grade of a glioma is extremely important for treatment planning and prognosis prediction. The study aimed to evaluate the usefulness of multiparametric perfusion-weighted imaging (PWI) and diffusion-weighted imaging (DWI) in preoperative glioma grading.

Methods

In this retrospective study, 63 individuals with brain tumors histologically confirmed, of which 23 had low-grade gliomas (LGGs) and 40 had high-grade gliomas (HGGs) were involved. We conducted this paper on apparent diffusion coefficient (ADC) maps using the entire tumor volume method, allowing us to use all ADC values of the tumor. Small-sample regions of interest (ROIs) were drawn to collect parameters of relative cerebral blood flow (rCBF), cerebral blood flow (CBF), and relative cerebral blood volume (rCBV), from both the tumor core and peritumoral edema. The PWI and DWI metrics were compared to identify the most accurate distinguishing HGGs and LGGs, analyze receiver operating characteristics (ROC), and evaluate the diagnostic performance using solitary parameters and combined.

Results

In diffusion MRI, there were significant differences in minimum ADC and mean ADC between LGGs and HGGs (p<0.05), with the larger area under the curve (AUC) of 0.898 found for mean ADC at a cut-off value of 1.275, with sensitivity of 82.6 % and specificity of 90 %. The maximum ADC value did not differ significantly (p>0.05). All perfusion parameters in both the tumor core and peritumoral edema area were significantly greater values in cases of HGG compared to LGG (p<0.001), with the highest AUC of 0.946 found for solid tumor rCBV value (rCBVt), the cut-off is 3.585, sensitivity of 85 % and specificity of 100 %. Combining mean ADC and rCBVt provided an excellent AUC of 0.975, a sensitivity of 92.5 %, and a specificity of 91.3 % for differentiating between HGGs and LGGs.

Conclusions

Perfusion and diffusion MRI are valuable in discriminating between high-grade and low-grade gliomas, with the major criterion in the decision-making process being the combined mean ADC and rCBVt parameters.
Study of chronic myeloid leukemia with T-cell under fractal-fractional order model
Authors: Shah Kamal , Ahmad Shabir , Ullah Aman , Abdeljawad Thabet
Published: May 2024

This research work is devoted to investigate myeloid leukemia mathematical model. We give some details about the existence of trivial and nontrivial equilibrium points and their stability. Also, local asymptotical stability of disease-free and endemic equilibrium points is discussed. Also, positivity of the solution has been discussed. Some sufficient results are achieved to study the local existence and uniqueness of solution to the considered model for Mittag–Leffler kernel using the Banach contraction theorem. Three numerical algorithms are derived in obtaining the numerical solution of suggested model under three different kernels using Adams–Basforth technique. Numerical results have been presented for different fractals and fractional orders to show the behavior of the proposed model.
Objects of the Mind: using film to explore the entangled histories of media and mental health
Authors: Snelson Tim , Booth Toni , Macauley William , Jamieson Annie , McEnroe Natasha , Hurley Selina , Dabin Katie
Published: May 2024

This article presents the findings of an Arts and Humanities Research Council (AHRC) project, Objects of the Mind: engaging publics in the material cultures of media and mental health (AH/W002140/1), which was co-investigated by academics at the University of East Anglia and the University of Manchester and curators from across the Science Museum Group (SMG). Through this co-investigation we sought to tap into public interest in the SMG object collections and the accessibility of popular films (supplied by partners StudioCanal) to engage new audiences for our research on the interactions of psychiatry and cinema. From the museum perspective, we sought to use this research to ask new questions and tell new stories about the SMG objects, and to foster cross-collection dialogue between medicine (Science Museum) and media (National Science and Media Museum) collections. We discuss a range of events, activities and outputs we delivered towards these aims, but focus particularly on three new films we produced that (re)combined museum objects, feature film clips and expert interviews to tell new, enhanced or entangled stories about and across the collections. We will use these three short films to demonstrate three dialogues the project fostered: between museum collections; between histories; and between academic disciplines.
Global Infectious Diseases between January and March 2024: Periodic Analysis
Authors: Jiang Tingting , Zhao Xiaona , Tao Zhiyuan , Zou Jiazhen , Yu Wenjin , He Minjing , Gu Dayong , Zhang Shuqiong , Zhang Wanyi , Ho Hopui
Published: May 2024

In recent years, humanity has faced formidable challenges posed by infectious diseases. For example, previously controlled infectious diseases have undergone resurgences, while ongoing pathogen mutations have given rise to drug-resistant strains. These developments, coupled with changes in natural and societal factors, have contributed to the emergence of new infectious diseases. Spring is a season prone to infectious diseases, with common examples including influenza, measles, smallpox, and dengue fever. These diseases are primarily transmitted through respiratory droplets, airborne transmission, and close contact. To gain insight into the global distribution of infectious diseases we analyzed data from the Global Epidemic Information Monitoring System, which was developed by Shusi Technology, from January to March 2024.
“It is necessary to act with extreme caution in order to protect the soviet authorities from any accusations of interference in religious affairs”. An unknown document of the State Political Directorate on instigating the split in the Russian Orthodox Church
Authors: Savin Andrey
Published: May 2024

The article introduces a new document of the GPU Secret Department on the instigating the Renovationist split in the Russian Orthodox Church. This is the postal telegram No. 24968s of May 29, 1922, signed by the Head of the Secret Operative Directorate of the GPU V. R. Menzhinsky, and by the Head of the Secret Department of the GPU T. P. Samsonov. This telegram is part of a set of directives issued by the GPU, which initiated and regulated the church schism in 1922. Earlier, the researchers at Orthodox Svyato-Tikhonovsky University of Humanities published two directives of the GPU Secret Department, sent out from Moscow in the summer and fall of 1922. The documents describes the specific role that the GPU played in the beginning of the campaign to instigate split in spring-summer of 1922. In particular, the telegram deals with the actions of the GPU at the very beginning of the campaign. The document shows that by this time, the leadership of the GPU had already developed two main strategies, which they then adhered to steadily during the campaign: complete secrecy and strict control over the actions of the renewed clergy. The publication also describes specific measures taken by the GPU in Siberia immediately after receiving the Circular of May 29, 1922: the establishment of the renovationist Siberian church department ("Sibtserkov’") and the trials of the Tomsk Vicar and Barnaul Archbishop Victor (Bogoyavlensky) and the Irkutsk and Verkholensk Archbishop Anatoly (Kamensky).
The conflict between the Russian ecclesiastical mission in Jerusalem and the Imperial Orthodox Palestinian society in 1909–1914: a new interpretation
Authors: Kovalskaya Elena
Published: May 2024

The article is devoted to the history of the relationship between two Russian organizations: the Imperial Orthodox Palestinian Society (IPPO) and the Russian Ecclesiastical Mission in Jerusalem (RDM) at the early XX century.The RDM entered into a struggle with the IPPO for the leading position among Russian institutions in the Holy Land. The problem was aggravated by indetermination of the functions of these structures and their interdependence. The main reason for the conflict was competition for accommodation of the Russian pilgrims and associated income. Another challendge to the IPPO was note of head of the RDM Archim. Leonid (Sentsov) sent to the Holy Synod criticizing the activities of the Society and proposing to allow the RDM to control the schools of the Palestinian Society and the organization of the pilgrimage movement. The discovery of new archival sources provides a more accurat picture of the clash of interests of the Russian organizations in Palestine, the participants in this confrontation and unpublic mechanisms of solving such issues. Russian representatives in Palestine often acted uncontrollably, promoting their own business interests. It was obvious that consolidation of all Russian institutions in the Middle East was necessary, but the question was who would head this system, including controlling the funds sent from Russia to Palestine. The conflict between the RDM and the IPPO was resolved at the highest political level. Grand Duchess Elizabeth Feodorovna had more opportunities to influence the Emperor than the bishops of the Holy Synod. This fact predetermined success of the IPPO. At the same time, the Grand Duchess did not seek to weaken the RDM, but, on the contrary, insisted on raising the status of its prior to strengthen the position of the Russian Orthodoxy in the Holy Land.
“Tuesdays” and “Sundays”: the question of existence of the brotherhood “Christ and Liberty”
Authors: Kashin Vladislav
Published: May 2024

The article is devoted to the study of one of the main controversial points in the historiography of the largest post-revolutionary religious and philosophical association of Petrograd-Leningrad in the 1920s - "Voskresen’ya". This issue is connected with the history of the brotherhood "Hristos i Svoboda" ("Christ and Freedom"), created, according to the established historiographical tradition, at the religious and philosophical circle "Voskresen’ya". It was revealed that the only source through which we learn about the existence of this "brotherhood" are the memories of E.N. Fedotova. Other sources do not contain a word about this "brotherhood". It is not mentioned either in the investigative materials or in the memoirs of the participants of the "Voskresen’ya". Almost all researchers of the history of "Voskresen’ya" ignore this moment, and only two articles express doubts about the existence of this brotherhood, which are not supported by evidence.In this study, an attempt is made to consider this issue more closely than it was done earlier. All currently available sources on the history of religious and philosophical associations - "Vtorniki" and "Voskresen’ya" – were reviewed and analyzed. As a result of the analysis of the historiography of the issue, errors and inaccuracies existing in the works of researchers related to the history of "Vtorniki" and "Voskresen’ya" were revealed. As a result of the application of the comparative historical method, it was possible to reveal that all publications mentioning the "brotherhood" unreasonably call it the brotherhood "Hristos i Svoboda", ignoring the fact that there is no information in the source to support this judgment, since E.N. Fedotova mentions precisely the "brotherhood with the vow "Christ and Freedom", without a clear designation of its name.It was revealed that the vow "Christ and Freedom" mentioned by E.N. Fedotova really took place within the framework of the activities of the "Voskresen’ya". The combination of these words in the updated program of "Voskresen’ya" from 1928, as well as a number of other indirect facts, allowed us to draw a parallel and put a sign of identity between the brotherhood "Hristos i Svoboda" and "Voskresen’ya". On the basis of indirect signs, the fact of inaccuracies and unreliable facts in the memoirs of E.N. Fedotova, it was assumed that the message about the "brotherhood" was based on the erroneous ideas of E.N. Fedotova. Since her husband G.P. Fedotov participated in the meetings of the Brotherhood of St. Sophia in Petrograd, it remains likely that years later E.N. Fedotova could have mistakenly used the word "brotherhood" in relation to the religious and philosophical association known to us as "Voskresen’ya".
On free proof and regulated proof
Authors: Jiahong HE
Published: May 2024

Free proof and regulated proof are two basic modes of judicial proof. The system of ‘legal proof’ established in France in the 16th century is a classical model of regulated proof. The system of ‘free proof with intimate conviction’ established in France in the 19th century is a classical model of free proof. The force of seeking truth pushes the judicial proof towards the free mode, while the force of seeking fairness, predictability, and authority pushes the judicial proof towards the regulated mode. The interaction of these two driving forces causes the ‘reversal development’ of the judicial proof. In the long history of China, the judicial proof was in the scope of free proof. In responding to the need for judicial reform, Chinese system of judicial proof has been going from free proof to regulated proof, and is a mixture of the two modes now. The new technologies of internet, big data and artificial intelligence have provided great support for the development towards the regulated proof.
Nota editorial
Authors: Marquinez Xavier
Published: May 2024

El comité editorial de Acta Biológica Colombiana quiere rendir un merecido homenaje al Dr. Reinhard Schnetter por su apoyo como Editor Académico de la revista durante toda su historia (1982-2023) y por su contribución excepcional al desarrollo de las ciencias biológicas en Colombia
MORFOMETRÍA GEOMÉTRICA DE ESPECIES DE PECES TROPICALES DEL GÉNERO Pimelodella (HEPTAPTERIDAE) DE LA ORINOQUÍA
Authors: Cortés Hernández Miguel Ángel , Ramírez Gil Hernando
Published: May 2024

Pimelodella es uno de los géneros más diversos de la familia Heptapteridae con aproximadamente 83 especies válidas. Sin embargo, la taxonomía de este género es problemática ya que carece de un diagnóstico filogenético y sus especies presentan morfologías conservadas. Por lo tanto, este estudio tiene como objetivo analizar la variación morfológica de siete especies de Pimelodella de la cuenca del río Orinoco en Colombia. Para ello se utilizaron 93 ejemplares agrupados en siete especies, los cuales fueron orientados y escalados a través de un Análisis de Procrustes Generalizado (AGP). El tamaño explica parte de la variación de forma en las especies de Pimelodella analizadas. El Análisis de Variables Canónicas (ACV) realizado a los residuales indica que los dos primeras componentes explican el 92,4 % de la variación total, donde existe superposición entre P. figueroai, P. megalops, P. metae y Pimelodella sp. Sin embargo, la mayoría de los especímenes permanecieron relativamente cohesionados en sus respectivas especies. La probabilidad de tipicidad reveló una precisión de clasificación general del 86,0 % para los datos de validación cruzada. La morfometría geométrica nos permitió detectar diferencias de forma en especies de Pimelodella.
MOSQUITO CONTROL AND SCRAP TIRES: SAME OLD PROBLEM, NO RELIABLE STRATEGIES
Authors: Quezada-Yaguachi Walter , Alquisira-Domínguez Miriam , Vázquez-Anzúres Miriam J. , Rebollo-Salinas Dania Berenice , Rescalvo-Luna Luz Dalila , Correa-Morales Fabián , González-Acosta Cassandra , Moreno-García Miguel
Published: May 2024

Artificial breeding sites in urban areas have favored the domestication of mosquito vectors. Scrap tires are an important breeding source for mosquito larvae. Few efforts have been made to establish appropriate management measures for used tires, which poses a challenge for larval control activities. Here we mention the inconveniences of tire disposal and the physical and chemical control alternatives. We also note the available methods of larvicide application against larvae in tires and the advantages and disadvantages of each method. The possible effect of overdose/underdose on the development of resistance is considered. Finally, we mention that the actions of vector control programs, the local or state government policies, and active community participation must be interconnected to develop effective tire management.
PRIMER REGISTRO DE Ulmeritoides TRAVER (EPHEMEROPTERA: LEPTOPHLEBIIDAE) PARA EL CHOCÓ, COLOMBIA
Authors: Mosquera-Murillo Zuleyma , Mosquera-Mosquera Mairyn Minerva
Published: May 2024

En este trabajo se documenta por primera vez la presencia del género Ulmeritoides (Ephemeroptera: Leptophlebiidae) para el departamento del Chocó, Colombia. El registro se basa en ninfas colectadas en una pequeña laguna en el municipio de Condoto, departamento del Chocó, que se encuentran depositadas en la Colección Limnológica del Chocó (CLCH Insec-001309).