bluuebunny/crossref_metadata_2025 huggingface dataset:
Modelo de tomada de decisão para uso de professores do ensino fundamental na identificação de Autismo e Deficiência Intelectual
Authors: Teixeira Maria Cristina Triguero Veloz , Carreiro Luiz Renato Rodrigues , Seabra Alessandra Gotuzo , Silva Leandro Augusto da , Rossi Ana Claudia , Tafla Tally Lichtensztejn , Lopes Erick Fernando Doria , Brunoni Decio
Published: May 2020

Ainda há um número significativo de alunos que ingressam no ensino fundamental com transtornos do neurodesenvolvimento, como o Transtorno do Espectro Autista (TEA) e a Deficiência Intelectual (DI), sem diagnóstico garantindo seus direitos legais aos Serviços Educacionais Especiais (SES). De acordo com o sistema público de saúde brasileiro (SUS), a identificação precoce e o monitoramento do TEA devem ser realizados pelas equipes de saúde e educação. O objetivo deste estudo foi desenvolver um modelo de tomada de decisão, com um fluxograma detalhando tarefas e ações, utilizado por professores do ensino fundamental do sistema público de ensino com instrumentos para avaliação de indicadores de TEA e DI. O estudo foi realizado em duas fases. Fase 1: Dois instrumentos em um formato de checklist de verificação foram produzidos contendo descrições sobre as características dos transtornos para auxiliar o professor na avaliação dos alunos. Fase 2: Dois fluxogramas foram criados, um para cada transtorno, composto por um conjunto de atividades sequenciais logicamente organizadas. O procedimento para os fluxogramas consistiu em um processo baseado no Business Process Model and Notation (BPMN), utilizando a plataforma de código aberto Business Process Management System (BPMS). O relatório final permite a visualização dos resultados da avaliação, como indicadores do checklist, avaliação neuropsicológica, avaliações emocionais e comportamentais. O estudo apresenta um modelo de processo para professores e gestores educacionais que utiliza um sistema computadorizado para auxiliá-los na coleta e análise de dados, bem como tomada de decisão em tempo real para identificar alunos com suspeita de transtornos do neurodesenvolvimento.
Escolhas teórico-metodológicos para pesquisas em educação
Authors: Silva Simone Gonçalves
Published: May 2020

O presente trabalho visa discutir os caminhos percorridos durante o processo de constituição de uma Tese de Doutorado em Educação, que teve o ENEM como foco de investigação. Para tanto, apresenta-se os três princípios que contribuíram para o processo de construção teórico-metodológico, a saber: a perspectiva, momento que são evidenciados os posicionamentos teóricos-metodológicos a qual a pesquisa se filia; o movimento, etapa que são elencados os procedimentos utilizados para a geração de dados; por último, a análise, no qual são definidas as ferramentas analíticas que possibilitam olhar para o material empírico. Os princípios destacados serão discutidos de maneira articulada a exemplificação de uma pesquisa realizada. Por fim, entende-se que perspectiva, movimentos e análise formam uma tríade que pode contribuir para as pesquisas no campo da Educação.
O efeito do capital escolar no acesso ao Programa Ciência sem Fronteiras
Authors: Gomes Catarina Barbosa Torres
Published: May 2020

Este artigo aborda possíveis efeitos do capital escolar no acesso à mobilidade acadêmica internacional ofertada pelo programa Ciência sem Fronteiras, e tem como objetivo analisar a influência tanto do passado escolar na determinação de um perfil ideal para a mobilidade acadêmica quanto do percurso escolar e de experiências de mobilidade nessa trajetória. Em síntese, a intenção é a de verificar a hipótese de estarmos diante de uma “elite escolar”, composta por sujeitos que passaram por um rigoroso processo de seleção escolar que, por meio de investimentos familiares e pessoais, tiveram as condições requeridas para o acesso a esse tipo de mobilidade. Tanto no contexto internacional, sobretudo na Europa, em função da amplitude do programa Erasmus, quanto no Brasil, o tema tem ganhado espaço, sobretudo após o advento do CsF, o que evidencia sua importância no cenário das políticas educacionais mundiais. A metodologia de análise fundamentou-se nos parâmetros da amostragem aleatória simples e análise de conteúdo. Os resultados comprovaram a hipótese de que o perfil do estudante considerado apto à mobilidade, sobretudo selecionado com as bolsas para instituições mais concorridas também tinham uma trajetória escolar sem percalços, até mesmo no contexto universitário. Muitos eram ligados às atividades de iniciação científica, monitoria e extensão universitária. Será designado como CsF nas próximas referências.
A escolarização de jovens privados de liberdade no Centro Socioeducativo Santa Juliana
Authors: Avilar Wilkerson Oliveira , Zanella Maria Nilvane
Published: May 2020

A preocupação basilar deste estudo é refletir sobre as práticas socioeducativas de jovens privados de liberdade, com destaque para a escolarização como meio de emancipação política dos sujeitos responsabilizados pelo cometimento de atos infracionais. Este artigo tem como objetivo analisar os espaços e as condições em que ocorre o processo formal de ensino-aprendizagem de adolescentes e jovens internados (provisórios e sentenciados) no Centro Socioeducativo Santa Juliana, localizado em Rio Branco, Capital do Estado do Acre, à luz dos parâmetros do Sistema Nacional do Atendimento Socioeducativo (SINASE) e legislações que tratam do tema de forma específica. Para alcançar os objetivos propostos utilizamos como recurso teórico-metodológico a pesquisa documental (análise pormenorizada de materiais já publicados na legislação brasileira e estadual), bibliográfica (análise de artigos e obras de autores renomados na área de educação e socioeducação) e empírica. O recorte temporal da coleta de dados possui como registro os meses de junho a agosto de 2016, por meio do acompanhamento da rotina institucional e da análise de dados fornecidos pela administração da Unidade socioeducativa que é realizada pelo Instituto Socioeducativo (ISE). A análise possibilitou aos pesquisadores concluírem que as condições estruturais e de superlotação impossibilitaram, no período analisado, a garantia de escolarização a todos os internos, contribuindo com a precarização do atendimento socioeducativo e o diagnóstico da violação de direitos fundamentais estabelecidos pelo Estatuto da Criança e do Adolescente.
A gestão da evasão nas políticas educacionais brasileiras
Authors: Santos Junior José da Silva , Magalhães Ana Maria da Silva , Real Giselle Cristina Martins
Published: May 2020

O processo de expansão da educação superior no Brasil contemplou nas últimas décadas tanto a graduação como a pós-graduação, com a entrada de número significativo de mais estudantes em ambos os níveis. Contudo, existem problemáticas ainda não solucionadas que compõem a agenda dos gestores educacionais, representando desafios para a educação superior no que se refere à permanência do estudante no curso de ingresso. A evasão universitária é uma delas, representando perdas para todo o sistema educacional brasileiro, incidindo ainda na sociedade, uma vez que há recursos públicos investidos. O objetivo do artigo é analisar como se constata o processo de gestão da evasão no Brasil a partir das políticas de educação nacionais formuladas para o aprimoramento da graduação e da pós-graduação stricto sensu nas últimas décadas. A investigação é quanti-qualitativa, analisando-se pesquisas já produzidas sobre o tema, documentos e dados estatísticos obtidos a partir de sites oficiais do Inep e da Capes. Verifica-se que as ações governamentais de controle à evasão tiveram rumos diferenciados para a graduação e a pós-graduação stricto sensu. Para o caso da graduação, as ações tiveram seu foco na implementação de políticas de assistência estudantil, enquanto que na pós-graduação stricto sensu, as ações foram voltadas para medidas avaliativas. No entanto, não se sabe quais as limitações dessas políticas, tendo em vista a diversidade de questões que envolvem o tema da evasão e da permanência na educação superior, cuja discussão é necessária para fortalecer o processo de expansão em curso e aprimorar seus mecanismos de gestão.
CONTRIBUTION OF ISLAMIC LAW IN INDONESIAN LEGAL POLITICS
Authors: Murdan Murdan
Published: May 2020

Some Indonesian people assume that Legal Policy is not much different from the politicization of law, and some other people conclude that legal policy is the political domination of the law. This view or conclusions about legal policy is high mistake or fault. In the context of Indonesian legal science, the legal policy in the direction of legal policy issued officially by the state and all its attributes to achieve the country or state goals. So, what the mean about the legal policy on Islamic law? The meaning of Islamic LegalPolicy is the contribution of Islamic Law in various legal developments in Indonesia, which aims to help realize or achieve the objectives of the implementation of the Unitary State of the Republic of Indonesia. This paper will discuss and present descriptions of the concepts of Islamic LegalPolicy in Indonesia and the contribution of Islamic Law in the development of Indonesian national Law, which is oriented towards efforts to realize the ideals and objectives of the establishment of the Indonesian Law.
DIVERSI CONCEPT IN COMPLETION OF CHILDREN'S CRIMINAL CASE
Authors: Jalilah Nisfawati Laili
Published: May 2020

Child protection is all activities to guarantee and protect children and their rights so that they can live, grow, develop, and participate optimally by human dignity and dignity, and get protection from violence and discrimination. Related to this, in resolving child criminal cases, the Criminal Justice Act (UUPPA) emphasizes that the concept of Restorative Justice or Diversity must be used, namely the transfer or transfer of the judicial process to an alternative process of settlement of the case, namely through deliberation or mediation. The purpose of diversion is to prevent children from detention, avoiding labeling children as criminals, preventing the repetition of criminal acts committed by children, so that children are responsible for their actions, carrying out interventions needed for victims and children without having to go through a formal process. Avoiding children from following the justice system process, and keep children from the negative influence and implications of the justice process.Implementation of application of diversion in the juvenile criminal justice system is carried out at the level of investigation, prosecution, and case examination in district courts. The diversion process is carried out through deliberation by involving children and their parents/guardians, social counselors, and professional social workers based on a restorative justice approach. The results of the Diversion agreement can take the form of, inter alia; peace with or without compensation, restitution in the event of a victim, medical and psychosocial rehabilitation, participation in education or training at an educational institution or LPKS no later than 3 (three) months; or community service for a maximum of 3 (three) months.
ISLAMIC LAW PARADIGM (CLASSIC AND ALTERNATIVE)
Authors: Susfita Nunung
Published: May 2020

Paradigm is a collection of assumptions, concepts, and proportions that are logically put together and function to direct thought and study. Celestial religion before Islam has a limited capacity of time and place. The temporary nature is limited by the presence of the Prophet afterwards, such as the teachings of Musa a.s. The deadline is when the teachings of Isa a.s arrived. In contrast, the religion of Islam brought by the Prophet Muhammad is the last and final religion. The Qur'an is essentially a document of diversity and ethics that aims to be practical, to create a society of good morality and justice. The doctrine of freedom of human will as proclaimed by the Mu'tazillah is part of the theological concept of God's justice and defeats the original aspect of freedom and human responsibility. Among Orthodox, this human freedom means God's indifference. They accused the Mu'tazilah sect as extreme humanism, they asserted that God is outside the human concept of justice. What human beings see as God's justice does not mean that to Him, but what He does for humans does seem fair and rational to humans.
Dental anxiety – conditions, models, therapy
Authors: Sobol-Kwapińska Małgorzata , Senejko Alicja , Jaśkiewicz Leszek , Kwiatkowska Anna
Published: June 2020

Dental anxiety is a condition suffered by many dental patients. It causes psychological discomfort and avoidance of dental appointments, which in turn may lead to oral health issues. Dental anxiety has not yet been fully explored and seems to be still posing challenge to both dentists and psychologists. The aim of this article is to review dental anxiety studies, paying particular attention to the conditions, social, demographic and psychological correlations, as well as the ramifications of this type of anxiety. The article presents the most common psychological models of dental anxiety, methods to measure this type of anxiety and therapy techniques used with patients suffering from dental anxiety.
Local knowledge of the using tribe farmers in environmental conservation in Kemiren Village, Banyuwangi, Indonesia
Authors: Utomo Agus Prasetyo , Al Muhdhar Mimien Henie Irawati , Syamsuri Istamar , Indriwati Sri Endah
Published: May 2020

Using Farmers (Banyuwangi ethnic community) in Kemiren Village uses their ancestral knowledge in utilizing natural resources and the environment so that its sustainability is maintained. This study aims to identify the local knowledge of Using farmers in Kemiren Village, Banyuwangi Indonesia which plays a role in preserving their natural resources and environment. The study uses a qualitative approach and the data collection using documentation, interview, and field observation techniques. Data analysis uses methods cross-referenced and repeated information. Local knowledge of Using farmers that used to manage the environment is in the form of values (togetherness, obedience, consensus, fairness and caring), norms (prohibitions/taboo and suggestions in utilizing natural resources), belief (providing labuhan/offerings and selamatan/ritual), and practices in utilizing natural resources. The primary key that plays a role in environmental preservation is a harmonious relationship among farmers.
Theoretical Aspects, Experimental Investigations and Efficiency in Concrete Reinforcement by Organic Fibres
Authors: Lyakhevich G. D. , Grechukhin V. A. , Lyakhevich A. G. , Rozhantsev S. Yu.
Published: June 2020

Fibre concrete is a composite material reinforced by fibres. Construction of facilities while using concrete reinforced by organic fibres has rather long history. An analytical review of national and international investigations have shown that application of fibre concrete for bridge and tunnel structures significantly improves their physical and mechanical indices and, firstly, their service life. 3D strengthening of fibre concrete fundamentally changes properties of cement stone while ensuring high crack resistance of structures, increasing their resistance to impact and dynamic loads. Changes in volume ratio of various fibres in concrete make it possible to regulate material properties. It permits to increase its tensile strength, corrosion resistance, weather resistance and resistance to periodical moistening-drying and freezing-defrosting processes, and other indices are improved as well. The paper presents the developed technologies and fibre concrete compositions and contains description of manufactured and tested experimental specimens of non-pressure pipes reinforced by polypropylene fibres. The executed investigations have shown that the polypropylene fibres reduce probability of crack initiation and prevent their enlargement and when they are operated they depress growth of cracks and concentration of stresses in the field of macrodefects. Due to introduction of the fibre re-distribution of stresses caused by the process of structure formation has occurred from places of their concentration for the whole concrete volume. The fibre increases concrete resistance to compression and also improves service life of concrete at low temperatures and aggressive reagent action. The polypropylene fibres is expediently to apply for disperse reinforcement of structures working in bending, for example, being used for tunnel liner, bridge structures, concrete non-pressure pipes etc.
Development of a TB vaccine trial site in Africa and lessons from the Ebola experience.
Authors: Kaguthi Grace , Nduba Videlis , Rabuogi Prisca , Okelloh Douglas , Ouma Samuel G. , Blatner Gretta , Gelderbloem Sebastian J. , Mitchell Ellen M.H. , Scott Cherise P. , Verver Suzanne , Hawkridge Anthony , de Steenwinkel Jurriaan E.M , Laserson Kayla F. , Richardus Jan Hendrik
Published: May 2020

Tuberculosis is the deadliest infection of our time. In contrast, about 11,000 people died of Ebola between 2014 and 2016. Despite this manifest difference in mortality, there is now a vaccine licensed in the United States and by the European Medicines Agency, with up to 100% efficacy against Ebola. The developments that led to the trialing of the Ebola vaccine were historic and unprecedented. The single licensed TB vaccine (BCG) has limited efficacy. There is a dire need for a more efficacious TB vaccine. To deploy such vaccines, trials are needed in sites that combine high disease incidence and research infrastructure. We describe our twelve-year experience building a TB vaccine trial site in contrast to the process in the recent Ebola outbreak. There are additional differences. Relative to the Ebola pipeline, TB vaccines have fewer trials and a paucity of government and industry led trials. While pathogens have varying levels of difficulty in the development of new vaccine candidates, there yet appears to be greater interest in funding and coordinating Ebola interventions. TB is a global threat that requires similar concerted effort for elimination.
DSG2 expression is correlated with poor prognosis and promotes early-stage cervical cancer
Authors: Qin Shuhang , Liao Yuandong , Du Qiqiao , Wang Wei , Huang Jiaming , Liu Pan , Shang Chunliang , Liu Tianyu , Xia Meng , Yao Shuzhong
Published: May 2020

Background: The pathogenesis and developmental mechanism of early-stage (FIGO 2009 IA2-IIA2) cervical cancer (CC) remain unclear. Seeking novel molecular biomarkers based on The Cancer Genome Atlas (TCGA) will facilitate the understanding of CC pathogenesis and help evaluate early-stage CC prognosis. Methods: To identify prognosis-related genes in early-stage CC, we analyzed TCGA mRNA-seq data and clinical data by univariate Cox and Kaplan-Meier plotter analyses. Differential expression analysis identified upregulated genes in early-stage CC. Combined with the genes correlated with unfavorable prognosis, we selected DSG2 for further investigation. To detect DSG2 expression in early-stage CC, we used immunohistochemistry (IHC), quantitative real-time PCR (qRT-PCR) and western blotting. The relationship between the expression of DSG2 and clinical features was analyzed by the chi-square test. Cox analysis was applied to assess the relationship between CC overall survival (OS) and risk factors. The correlations between DSG2 expression and CC cell line proliferation and migration were investigated with Cell Counting Kit-8 (CCK-8) and migration assays. Results: There were 416 prognosis-related genes in early-stage CC. DSG2, MMP1, CA9, HOXA1, and SERPINB3 were upregulated in early-stage CC compared with adjacent noncancerous tissue (ANT) and correlated with unfavorable prognosis. Among them, DSG2 was most significantly correlated with patient survival. Coexpression analysis indicated that DSG2 was probably involved in cell division, positive regulation of transferase activity, positive regulation of cell migration, EGFR upregulation pathway and regulation of lymphangiogenesis. IHC, qRT-PCR and western blotting showed that DSG2 expression was higher in CC than in normal tissue. Significant correlations were identified between DSG2 expression and several aggressive clinical features, including pelvic lymph node metastasis (PLNM). Multivariate Cox analysis showed that DSG2 and PLNM were independent prognostic factors for OS. DSG2 knockdown inhibited CC cell proliferation and migration. Conclusions: DSG2 is a new biomarker that promotes tumor proliferation and metastasis and is correlated with poor prognosis in early-stage CC.
Comparative transcriptome analysis of genes involved in two peanut varieties under drought stress
Authors: Jiang Chunji , Li Xinlin , Zou Jixiang , Ren Jingyao , Jin Chunyi , Zhang He , Yu Haiqiu , Jin Hua
Published: May 2020

Background
Peanut is one of the most important world oil crops. Peanut qualities and yields are restricted dramatically by abiotic stresses particularly by drought. Therefore, it would be beneficial to gain a comprehensive understanding on regulatory mechanisms of the peanut genomic transcriptional activities responding to drought, and hopefully extracting peanut molecular drought-resistance mechanisms.
Results
In this study, two peanut varieties NH5 (resistant) and FH18 (sensitive) which showed significantly differential drought-resistance were screened from twenty-three main commercial peanut cultivars and used for physiological characterization and transcriptomic analysis. NH5 leaves showed higher water and GSH contents, faster stomatal closure and lower relative conductivity (REC) than FH18. Under the time-course of 0 h (CK), 4 h (DT1), 8 h (DT2) and 24 h (DT3), drought-treatments tent to exert repressive impacts on peanut transcriptomes since the number of down-regulated differential expressed genes (DEGs) increased with the progression of treatments in both varieties.
Conclusions
Nevertheless, NH5 seemed to maintain stabler transcriptomic dynamics than FH18. Furthermore, annotations of identified DEGs implicated that signal transduction, elimination of reactive oxygen species, maintenance of cell osmotic potential were key drought-resistance-related pathways. Last, examination of ABA and SA components suggested that the fast stomata closure in NH5 was likely to be mediated through SA rather than ABA signaling. In all, these results have not only provided us comprehensive pictures of peanut drought transcriptomic changes, but also laid a foundation for further identification of the molecular drought tolerance mechanism in peanut and other oil crops.
Ophthalmic assessment of newborns with hypoxic-ischemic encephalopathy treated with therapeutic hypothermia – retrospective study
Authors: Wojcik-Niklewska Bogumila , Sarnat-Kucharczyk Monika , Filipek Erita , Sobczyk Jerzy , Kohut Janina
Published: May 2020

The authors have requested that this preprint be removed from Research Square.
Transcriptome and mebabolomic profiling: the effect of LED light quality on morphological traits, and phenylpropanoid-derived compounds accumulation in Sarcandra glabra seedlings
Authors: Xie Dejin , Chen Lingyan , Zhou Chengcheng , Tarin Muhammad Waqqas Khan , Yang Deming , Ren Ke , He Tianyou , Rong Jundong , Zheng Yushan
Published: May 2020

Background
Sarcandra glabra is an evergreen and traditional Chinese herb, having medicinal significance as anti-oxidant, anti-bacterial, anti-inflammatory, and anti-tumor. Recently, China has initiated to establish cultivation of this plant in greenhouse under artificial light-emitting diodes (LED). However, little is known regarding the effects of the different LED lights on plant growth, accumulation pattern of secondary metabolites, and the molecular mechanism of Sarcandra glabra.
Results
Compared to white light (WL), the red light (RL) increased the height and decreased the stem diameter and leaf area, while blue light (BL) suppressed the height and leaf area. According to our transcriptome profiling, some differentially expressed genes (DEGs) were enriched in the phenylpropanoid biosynthesis. We identified 46 unigenes encoding for almost all known enzymes involved in phenylpropanoid biosynthesis, while the expression level of RNA-seq and qPCR were largely consistent. Meanwhile, we found 53 unigenes encoding R2R3-MYB proteins and 53 unigenes encoding bHLH proteins that several of them were related to flavonoids biosynthesis. Based on metabolomic profiling, a total of 454 metabolites were detected and the distribution of chemicals varied significantly. While flavonoids, phenolic acids, and tannins were mainly located in leaves; Organic acids, lignans and coumarins, and terpenoids were much more abundant in WG (root tissue under WL). Meanwhile, the yields of most flavonoids from BY (leaf tissue under BL) and the synthesis of primarily targeted compounds was lower than in WY (leaf tissue under WL) and RY (leaf tissue under RL). Instead, the leaves grown under RL exhibited a greater production of bioactive phytochemicals such as esculetin, fraxetin, esculin, and scopoletin.
Conclusion
These results provide further insight into the molecular mechanism of metabolites accumulation patterns in S. glabra under different light conditions, enabling the development of optimum breeding conditions for this plant.
Forest communities and factors responsible for vegetation pattern in the legally protected areas of the Kashmir Himalaya, India
Authors: Haq Sheikh Marifatul , Yaqoob Umer , Qazi Hilal
Published: May 2020

The authors have withdrawn this preprint due to author disagreement.
Development and validation of a nomogram for predicting survival of Pulmonary invasive mucinous adenocarcinoma based on Surveillance, Epidemiology, and End Results (SEER) database
Authors: Wang Yadong , Liu Jichang , Huang Cuicui , Zeng Yukai , Liu Yong , Du Jiajun
Published: May 2020

Background: Lung cancer remains the highest tumor mortality rate. In 2015, the cancer classification guidelines of the World Health Organization were updated. The term “invasive mucinous adenocarcinoma (IMA)” arouse people's attention, while the clinicopathological factors that may influence survival were unclear.Methods: Data of IMA patients was downloaded from SEER database. Kaplan-Meier methods and log-rank tests were used to compare the differences in OS and LCSS. The nomogram was developed based on the result of the multivariable analysis. The discrimination and accuracy were tested by Harrell's concordance index (C-index), receiver operating characteristic (ROC) curve, calibration curve and decision curve analyses (DCA). Integrated discrimination improvement (IDI) index was used to evaluate the clinical efficacy.Results: According to multivariate analysis, the prognosis of IMAs was associated with age, differentiation grade, TNM stage and treatments. Surgery might be the only way that would improve survival. Area under the curve (AUC) of the training cohort was 0.837and 0.840 for3-and 5-year OS, respectively. AUC for 3-and 5-year LCSS were separately 0.839 and 0.844. The new model was then evaluated by calibration curve, DCA and IDI index.Conclusion: Based on this study, prognosis of IMAs was systematically reviewed, and a new nomogram was developed and validated. This will help to comprehensively evaluate the prognosis of IMA patients and formulate reasonable treatment measures.
Status of MWth Integrated Gasification Fuel Cell (IGFC) Power Generation System Demonstration in China
Authors: Wei Chang , Liu Zhien , Li Chufu , Singh Surinder , Lu Haoren , Gong Yudong , Li Pingping , Wang Hanlin , Yang Xia , Xu Ming
Published: May 2020

This paper provides status update of IGFC power generation system being developed at National Institute of Clean-and-Low-Carbon (NICE) at MW th scale. This system is designed to use coal as fuel to produce syngas as a first step similar to integrated gasification combined cycles (IGCC). Subsequently, the solid oxide fuel cell system is used to convert chemical energy to electricity electrochemically without combustion, which is different from IGCC. This system leads to a higher efficiency as compared to a traditional coal-fired power plant. The unreacted fuel in the SOFC system is transported to an oxygen-combustor to be converted to steam and CO 2 . Through heat recovery system, the steam is condensed and removed, and CO 2 is enriched and captured for sequestration or other application, such as co-electrolysis of CO 2 and H 2 O using curtailed renewable energy for production of syngas. Comprehensive economic analysis for a typical IGFC system was performed and the results were compared with supercritical pulverized coal-fired (SCPC) power plant, showing the cost of electricity (COE) of IGFC could be up to 20% lower than that by SCPC with CO 2 capture. The SOFC stacks selected for IGFC development were tested and qualified under both hydrogen and simulated coal syngas fuel showing good consistency and stable long term performance. Experimental results using SOFC stacks and thermodynamic analysis (using ASPEN Plus) indicate that the hydrogen to CO ratio of the syngas is preferred to be 1.68 or higher to avoid carbon deposition inside of the fuel pipe. For lower H 2 /CO ratio, steam to CO ratio needs to be higher. Besides, the steam needs to be mixed well with the syngas above 100 o C and below the temperatures where carbon formation is thermodynamically favored. The 20kW SOFC power generation unit is being developed with design system conditions of 20 kW maximum power, current density of 0.334 A/cm 2 , DC efficiency of 50.41%, and fuel utilization of 80%. A 100kW subsystem will consist of 6 x 20kW power generation units, and the MW th IGFC system will consist of 5 x 100kW sub-systems.
Transcriptomic profiles of non-embryogenic and embryogenic callus cells in a highly regenerative Upland Cotton line (Gossypium hirsutum L.)
Authors: Wen Li , Li Wei , Parris Stephen , West Matthew , Lawson John , Smathers Michael , Li Zhigang , Jones Don , Jin Shuangxia , Saski Christopher
Published: May 2020

• Background
• Genotype independent transformation and whole plant regeneration through somatic embryogenesis relies heavily on the intrinsic ability of a genotype to regenerate.
• Results
• In this study, gene expression profiles of a highly regenerable Gossypium hirsutum L. cultivar, Jin668, were analyzed at two critical developmental stages during somatic embryogenesis, non-embryogenic callus (NEC) cells and embryogenic callus (EC) cells. The rate of EC formation in Jin668 is 96%. Differential gene expression analysis revealed a total of 5,333 differentially expressed genes (DEG) with 2,534 upregulated and 2,799 downregulated in EC. A total of 144 genes were unique to NEC cells and 174 genes unique to EC. Clustering and enrichment analysis identified genes upregulated in EC that function as transcription factors/DNA binding, phytohormone response, oxidative reduction, and regulators of transcription; while genes categorized in methylation pathways were downregulated. Four key transcription factors were identified based on their sharp upregulation in EC tissue; LEAFY COTYLEDON 1 (LEC1), BABY BOOM (BBM), FUSCA (FUS3) and AGAMOUS-LIKE15 with distinguishable subgenome expression bias.
• Conclusions
• This comparative analysis of NEC and EC transcriptomes gives new insights into the genetic underpinnings of somatic embryogenesis in cotton.
Leukopenia of Asymptomatic COVID-19 Infections under 18 Years Old in Recovery Stage
Authors: Zhang Wei , Yuan Youshu , Yang Zhengqiao , Fu Jinxia , Zhang Yun , Ma Ming , Wu Weidong , Zhou Hourong
Published: May 2020

Background In December, 2019, a type of novel coronavirus which was designated novel coronavirus 2019 (2019-nCoV) by World Health Organization (WHO) occurred in Wuhan, Hubei, China. The epidemiological and clinical characteristics of those patients under 18 years old in the recovery stage are limited. To compare the difference of epidemiological and clinical characteristics of COVID-19 involving 25 patients under 18 years old in recovery stage between confirmed and asymptomatic infections.Methods Retrospective, single-center cohort study of COVID-19 involving 25 patients under 18 years old in the recovery stage at Guizhou Provincial Staff Hospital in Guiyang, China, from January 29, to March 31, 2020; final date of follow-up was April 22. Epidemiological, demographic, clinical, laboratory, radiological, and treatment data were collected and analyzed. Epidemiological and clinical characteristics of confirmed COVID-19 infections and asymptomatic infections were compared.Results Among the 25 COVID infections under 18 years old, 16 (64%) were mild or moderate confirmed cases, and 9 (36%) were asymptomatic. The shortest treatment period was 6 days, the longest 26 days, and the average treatment period 14 days. Four cases (44.4%) had visited Wuhan or had a living story in the city. There were 9 (100%) asymptomatic cases were familial cluster outbreak, with an average infection number was 6 cases among all families. The number of asymptomatic COVID-19 infections’ Leukopenia were significantly more than confirmed cases (p = 0.04).Conclusions Leukopenia mostly occurred in asymptomatic COVID-19 infections under 18 years old compared with the confirmed patients.
Depression in patients with knee osteoarthritis: risk factors and associations with joint symptoms
Authors: Zheng Shuang , Tu Liudan , Cicuttini Flavia , Zhu Zhaohua , Han Weiyu , Antony Benny , Wluka Anita E. , Winzenberg Tania , Aitken Dawn , Blizzard Leigh , Jones Graeme , Ding Changhai
Published: May 2020

Background To describe demographic and clinical factors associated with the prevalence and incidence of depression and explore the temporal relationship between depression and joint symptoms in patients with symptomatic knee osteoarthritis (OA). Methods 413 participants were selected from a randomized controlled trial in people with symptomatic knee OA and vitamin D deficiency (age 63.2 ± 7.0 year, 50.4% female). Depression severity and knee joint symptoms were assessed using the patient health questionnaire (PHQ-9) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), respectively, at baseline and 24 months. Results The prevalence and incidence of depression was 25.4% and 11.2%, respectively. At baseline, having a higher body mass index (BMI), greater scores of WOMAC pain (PR: 1.05, 95%CI:1.03, 1.07), dysfunction (PR: 1.02, 95%CI:1.01, 1.02) and stiffness (PR: 1.05, 95%CI: 1.02, 1.09), lower education level, having more than one comorbidity and having two or more painful body sites were significantly associated with a higher prevalence of depression. Over 24 months, being female, having a higher WOMAC pain (RR: 1.04, 95%CI: 1.00, 1.08) and dysfunction score (RR: 1.01, 95%CI: 1.00, 1.02) at baseline and having two or more painful sites were significantly associated with a higher incidence of depression. In contrast, baseline depression was not associated with changes in knee joint symptoms over 24 months. Conclusion Knee OA risk factors and joint symptoms, along with co-existing multi-site pain are associated with the prevalence and development of depression. This suggests that managing common OA risk factors and joint symptoms could be important for prevention and treatment depression in patients with knee OA.
CENPF driven lung adenocarcinoma and lung squamous cell carcinoma with immune infiltrates
Authors: Li Lei , Zheng Pengchao
Published: May 2020

Background: CENPF (centromere protein F) is a critical gene that associates with the centromere-kinetochore complex and plays an important role in the tumor development. However, the associations of CENPF expression and tumor infiltrating lymphocytes in lung cancer remain unknown. Methods: CENPF expression and prognostic factor was analyzed via the Gene Expression Profiling Interactive Analysis (GEPIA) site. The correlation between CENPF and cancer immune infiltrates was investigated via and Tumor Immune Estimation Resource (TIMER) site. Further, correlations between CENPF expression and gene marker sets of immune infiltrates were analyzed by TIMER. Results: The TCGA database of Lung adenocarcinoma (LUAD) and Lung squamous cell carcinoma (LUSC) patients showed that high CENPF expression was associated with poorer overall survival (OS HR=1.5, P=0.01) and disease-free survival (DFS HR=1.4, P=0.027) in LUAD. Specifically, high CENPF expression have no correlated with worse OS (OS HR=0.78, P=0.071) and DFS (DFS HR=1, P=0.87) in LUSC. CENPF expression was positively correlated with infiltrating levels of B cells, macrophage in LUAD, B cells, and CD8+ T cells, macrophages, neutrophils, and dendritic cells (DCs) in LUSC. CENPF expression showed strong correlations with diverse immune marker sets in LUAD, and LUSC. After down-regulating the expression of CENPF, the proliferative capacity of Lung adenocarcinoma and Lung squamous cell carcinoma cells was inhibited. ﻿Conclusions: This report suggest that CENPF is high expression, correlated with poor prognosis and immune infiltrating levels of, including those of B cells, CD8+ T cells, CD4+ T cells, macrophages, neutrophils, and DCs in in LUAD and LUSC. In addition, CENPF expression is potentially closely related to the proliferation and metastasis of lung cancer cells. These studies suggest that CENPF can be used as a new prognostic target for determining prognosis and immune infiltration in Lung adenocarcinoma and Lung squamous cell carcinoma.
Vascular Obliteration Due To Endothelial And Myointimal Growth In COVID-19
Authors: Valtueña Jara , Martínez-García Gerardo , Ruiz-Sánchez Daniel , Garayar-Cantero María , Dueñas Carlos , Aguado-García Ángel , Paula Jose María Prieto de , López Pilar Manchado
Published: June 2020

Background: Severe coronavirus disease 2019 (Covid-19) is a systemic multi-organ viral invasion. Previous studies found that many patients had a procoagulant state and/or severe hypoxemia with relatively well-preserved lung mechanics. Mechanisms underlying the vascular and its surrounding tissue are not well known yet. Histological data in Covid-19 tissues´ patients are still limited and mainly focused on post-mortem analysis. Since SARS-CoV-2 largely affects cutaneous tissue, we aim to examine in depth skin lesions related to Covid-19 in order to understand better how the disease might affect living tissue.Methods: Five skin lesions from Covid-19 adult patients were selected for histological tissue examination. Vast amount of data of immunohistochemistry (IHC) and direct immunofluorescent (DIF) were part of the assessment. Results: A common strong vasculopathic reaction pattern based on prominent vascular endothelial and myointimal cellgrowth was identified. Endothelial cell distortion generated vascular lumen obliteration and a strike erythrocyte and serum extravasation. Extensive significant vascular C4d and C3 deposition throughout vascular cell wall was also identified. A regenerative epidermal hyperplasia with tissue structure preservation was found. Conclusions: Covid-19 could comprise an obliterative micro-angiopathy consisting on endothelial and myointimal intensive growth with complement activation. This mechanism, together with increased vascular permeability identified, could contribute to obliterative vascular lumen and hemorrhage in Covid-19. Activation of the complement and angiogenic pathways could have an important role in inducing and maintaining this vasculopathic reaction pattern. Thus, anticoagulation by itself could not completely reverse vascular lumen obliteration, with consequent hemorrhagic increased risk associated. Skin is the largest organ in the body, the most accessible one and can mirror other organs of the body. Findings of this study could contribute to a better understanding of physio-pathological mechanisms underlying SARS-CoV-2 infection on living tissue and could help further studies find potential targets for specific therapeutic interventions in Covid-19 severe patients.
Does Sars-Cov-2 Threaten Our Dreams? Effect of Quarantine on Sleep Quality and Body Mass Index
Authors: Barrea Luigi , Pugliese Gabriella , Framondi Lydia , Matteo Rossana Di , Laudisio Daniela , Savastano Silvia , Colao Annamaria , Muscogiuri Giovanna
Published: June 2020

Background: COVID 19- related quarantine led to a sudden and radical lifestyle changes, in particular in eating habits. Objectives of the study were to investigate the effect of quarantine on sleep quality (SQ) and body mass index (BMI), and if change in SQ was related to working modalities.Materials: We enrolled 121 adults (age 44.9±13.3 years and 35.5% males). Anthropometric parameters, working modalities and physical activity were studied. Sleep quality was evaluated by the Pittsburgh Sleep Quality Index (PSQI). At baseline, the enrolled subjects were assessed in outpatient clinic and after 40 days of quarantine/lockdown by phone interview. Results: Overall, 49.6% of the subjects were good sleepers (PSQI < 5) at the baseline and significantly decreased after quarantine (p<0.001). In detail, sleep onset latency (p<0.001), sleep efficiency (p=0.03), sleep disturbances (p<0.001), and daytime dysfunction (p<0.001) significantly worsened. There was also a significant increase in BMI values in normal weight (p=0.023), in subjects grade I (p=0.027) and II obesity (p=0.020). In all cohort, physical activity was significantly increased (p=0.004). However, analyzing the data according gender difference, males significantly increased physical activity compared to females in which there was only a trend without reaching statistical significance (46.5% vs 74.4%; p=0.015 and 50.0% vs 64.1%, p=0.106; in males and females, respectively). Also, smart working activity resulted in a significant worsening of SQ, particularly in males (p<0.001). Conclusions: Quarantine was associated to a worsening of SQ, particularly in males doing smart working, and to an increase in BMI values.
PADRONIZAÇÃO DISCRICIONÁRIA EM PROCESSOS HOSPITALARES: UM MODELO CONCEITUAL PARA A COMPREENSÃO DO TRABALHO EM AMBIENTES LEAN HEALTHCARE
Authors: De Carvalho Turati Ricardo , Veloso Saes Elizangela , De Oliveira Vasconcelos Karina
Published: May 2020

Os hospitais são grandes organizações de serviços responsáveis pelo bem estar da população e também por boa parte dos recursos financeiros destinados a saúde, de forma a desempenhar um importante papel na sociedade. Diante deste cenário, os hospitais tem demandado um aumento no uso de ferramentas de gestão e melhoria de seus processos de negócio, tendo como principal  direcionador  o Lean Healthcare. Desse modo, como forma de contribuir no aprimoramento das aplicações do Lean Healthcare em hospitais, apresenta-se o objetivo deste trabalho que constituiu na introdução de um modelo conceitual, o qual apresenta um novo conceito concernente ao processo de padronização do trabalho, denominado de Padronização Discricionária do Trabalho. Esse modelo consiste em inovar a forma como a padronização do trabalho tem sido aplicada em ambientes hospitalares. O modelo foi desenvolvido por meio de uma pesquisa teórica-conceitual, o que permitiu estabelecer e descrever três níveis de análise, as quais devem direcionar o processo de padronização e os diferentes níveis de customização o qual o processo está suscetível. As diferentes visões sobre a utilização da padronização do trabalho na manufatura e nos hospitais foram tratadas dando origem a 10 enfoques a serem observados. Desse modo, a contribuição da padronização discricionária do trabalho em processos hospitalares proposta neste estudo tem por missão dar destaque na padronização dos processos de trabalho existentes nos hospitais, afastando-se de uma visão restrita em determinar qual deve ser o trabalho prescrito, uma vez que este último deve estar sob a competência do corpo clínico. Um modelo conceitual foi desenvolvido, o qual permite identificar as particularidades de cada setor do hospital e adequar à padronização de acordo com seu respectivo  setor ou departamento.
PANORAMA DO DESEMPENHO INOVATIVO DAS INDÚSTRIAS FARMACÊUTICAS SITUADAS NO BRASIL
Authors: Oliveira Carlos Eduardo de , Silva Raiane Carla da
Published: May 2020

Este estudo teve como objetivo apresentar o panorama da inovação nas indústrias do setor farmacêutico. Esta pesquisa descritiva utilizou as edições de 2000, 2003, 2005, 2008, 2011 e 2014 da Pesquisa de Inovação (PINTEC). Foram investigados, do setor de Indústria de Transformação e do setor Farmacêutico, os seguintes itens: Média Receita Líquida de Vendas, Média dos Gastos em atividades inovativas e de seus 8 tipos de Gastos, e o grau de importância (alto e médio) captados pelas 13 variáveis de impacto nas atividades inovativas. Os principais resultados apontam a evolução da inovação nas indústrias do setor farmacêutico no decorrer dos anos a partir dos crescentes investimentos destinados a várias áreas, como a aquisição de outros conhecimentos externos; aquisição de máquinas e equipamentos; introdução das inovações tecnológicas no mercado e projeto industrial e outras preparações técnicas. E ainda, os resultados apresentaram o aumento da média da Receita Liquida de Vendas no setor em estudo e a diferença dessa média em relação à média da Receita Liquida de Vendas das indústrias de transformação, a qual se mostrou em todo tempo superior.
CO2 emissions analysis for East European countries: the role of underlying emission trend
Authors: Guven Denizhan , Özgür Kayalica M. , Kayakutlu Gülgün
Published: June 2020

This paper aims to analyze the impact of energy consumption, economic structure, and manufacturing output on the CO2 emissions of East European countries by applying the Structural Time Series Model (STSM). Several explanatory factors are used to construct the model using annual data of the 1990–2017 period. The factors are: total primary energy supply, GDP per capita and manufacturing value added, and, finally, a stochastic Underlying Emission Trend (UET). The significant effects of all variables on CO2 emissions are detected. Based on the estimated functions, CO2 emissions of Belarus, Ukraine, Romania, Russia, Serbia, and Hungary will decrease, by 2027, to 53.2 Mt, 103.2 Mt, 36.1 Mt, 1528.2 Mt, 36 Mt, and 36.1 Mt, respectively. Distinct from other countries, CO2 emissions of Poland will extend to 312.2 Mt in 2027 due to the very high share of fossil-based supply (i.e., coal and oil) in Poland. The results also indicate that the most forceful factor in CO2 emissions is the total primary energy supply. Furthermore, for Poland, Romania, Hungary, and Belarus, the long-term impact of economic growth on CO2 emissions is negative, while it is positive for Russia, Ukraine, and Serbia. The highest long-term manufacturing value-added elasticity of CO2 emissions is calculated for Serbia and Belarus.