bluuebunny/crossref_metadata_2025 huggingface dataset:
Risk of inappropriate fixation position for patients with cleft lip and palate after head and neck extension
Authors: Tsukamoto Masanori , Matsuo Kazuya , Yokoyama Takeshi , Hano Kazuhiro , Eto Michi
Published: December 2023

Preformed oral tubes are preferred in clinical practice due to airway patency for enough operative fields during procedures. However, as the tube moves away from the carina during neck extension performed for procedures following intubation, the tracheal tube cuff may compress the vocal cords and potentially cause balloon-induced injury. In this study, we retrospectively investigated the incidence of tube replacement after procedures involving head and neck extension. We retrospectively investigated pediatric patients (6–15 years) who underwent oral surgery. Intubation was performed using a cuffed 5.0–7.5 mm ID RAE oral tube. Patients were subsequently positioned with a hyperextended neck for surgical procedures. The tube cuff position was reconfirmed by video laryngoscope, and the tube was replaced by a wire-reinforced tube. This retrospective study included 185 patients. We observed no intraoperative respiratory complications in this study. Among 186 patients, 16 (8%) underwent tube replacement owing to inaccurate cuff position after neck extension. Fixation of the lower lip in RAE tube was 17.9 ± 1.8 cm, which was not significantly different from values using wired-reinforced tracheal tubes 18.9 ± 2.3 cm. We observed that inappropriate tube positioning after head and neck extension occurred in 16 patients (8%). Anesthesiologists should closely monitor and confirm the position of the tube cuff for safe airway management.
Activated tissue-resident macrophages contribute to hair cell insults in noise-induced hearing loss
Authors: Pan Jing , Wang Kaiye , Qu Jiaxi , Chen Dongxiu , Chen Anning , You Yunyou , Tang Jie , Zhang Hongzheng
Published: December 2023

Background
Macrophages serve as the primary immune cell population and assume a pivotal role in the immune response within the damaged cochleae, yet the origin and role of macrophages in response to noise exposure remains controversial.
Methods
We generated Ccr2RFP/+ Cx3cr1GFP/+ dual-reporter mice to identify the infiltrated and tissue-resident macrophages in the noise-exposed cochlea.
Results
Under steady-state, tissue-resident macrophages present in the Rosenthal's canal (SGNs), spiral ligament, and basilar membrane of the adult cochlea. After noise exposure, activated resident macrophages change in morphology, increase in abundance, and migrate to the region of hair cells, leading to the loss of outer hair cells and the damage of ribbon synapses. Meanwhile, peripheral monocytes are not implicated in the noise-induced hair cell insults. Furthermore, the noise-induced activity and redistribution of macrophages were abolished by the inhibition of TLR4 signaling, resulting in alleviated insults of hair cells and partial recovery of hearing function.
Conclusions
Our findings point to cochlea resident macrophages as pro-inflammatory and detrimental players in acoustic trauma and introduce a potential therapeutic target in noise-induced hearing loss.
Association between breast and endometrial cancer: a two-way Mendelian randomization study
Authors: Zhao Chengyi , Qian Yao , Yuan Haiyu , Guo Ruizhao , Cui Xiaoqiao , Liu Feng
Published: December 2023

Background
Breast cancer is the most prevalent cancer worldwide, and endometrial cancer is one of the most common gynecological cancers. Observational studies have shown an association between breast and endometrial cancers, but it may be influenced by potential confounding factors. Meanwhile, Mendelian randomization (MR) studies can overcome these confounding factors to assess causality.
Methods
We obtained breast cancer data (122,977 breast cancer cases and 105,974 controls) and endometrial cancer data (12,906 endometrial cancer cases and 108,979 controls) indirectly from the Breast Cancer Association Coalition (BCAC) and the Endometrial Cancer Association Consortium (ECAC) through the IEU Open GWAS program(https://gwas.mrcieu.ac.uk/). Then, Inverse variance weighting (IVW) was used as the primary analysis method. Sensitivity analyses were performed by multiple MR methods to ensure the accuracy of the results.
Results
Based on the IVW approach, our study found that patients with endometrial cancer have an increased risk of developing breast cancer (OR:1.072; 95% CI: 1.027–1.119; p = 0.002), especially the ER + subtype of breast cancer (OR:1.072; 95% CI: 1.029–1.129; p = 0.001). Similarly, reverse MR analyses showed an increased risk of endometrial cancer in breast cancer patients (OR:1.078; 95% CI: 1.018–1.141; p = 0.009), particularly in those who were ER+ (OR:1.075; 95% CI: 1.015–1.137; p = 0.013). However, the bidirectional MR analyses did not reveal any proof of a connection between endometrial cancer and ER- breast cancer.
Conclusions
We found a bidirectional causal effect between breast and endometrial cancer, especially ER + breast cancer. Therefore, our study supports timely screening and prevention of endometrial cancer in breast cancer patients and vice versa. At the same time, we suggest further exploration of the potential pathogenic mechanisms between breast cancer and endometrial cancer.
Bond analysis in meta-, and para-substituted thiophenols: overlap descriptors, local mode analysis, and QTAIM
Authors: Barbosa Willis , Santos Carlos , Andrade Railton , Lucena Juracy , Moura Renaldo
Published: December 2023

Context: This study delves into the chemical nuances of thiophenols and their derivatives through a comprehensive computational analysis, moving beyond traditional energetic perspectives such as bond dissociation enthalpy and S−H dissociation dynamics. By employing the overlap model along with its topological descriptors (OP/TOP), Quantum Theory of Atoms in Molecules (QTAIM), and Local Vibrational Mode (LVM) theories, the research provides a deeper understanding of the S−H and C−S bonding scenarios in substituted thiophenols. The investigation follows the electron-donating capacity of S−H substituent variation with the nature and positioning of other ring substituents.
Energy profile analyses indicate distinct stability differences in the cis and trans conformations of meta- and para-PhSH systems, influenced by the electron-donating strength of these substituents. The study also uncovers significant variations in S−H bond distances and descriptor values, particularly in para-substituted PhSH, reflecting the influence of electron-donating or withdrawing substituents. In contrast, alterations at the meta- position show minimal effects on C−S bond descriptors, while pra- substitutions markedly influence C−S bond characteristics, demonstrating a clear correlation with the electron-donating or withdrawing capabilities of the substituents. This research sheds light on the intricate bond dynamics in aromatic systems with diverse substituents, highlighting the complex interaction between electronic effects and molecular conformation.
Methods: The study employs the ωB97X-D/Def2TZVP level of theory for molecular geometries, ensuring accurate characterization of structures as true minima via analytical harmonic frequency determination. The electronic properties of S−H and C−S bonds in variously substituted thiophenols were analyzed using OP/TOP, QTAIM, and LVM methodologies. Computational processes,including conformational scans, geometry optimizations, and vibrational frequency calculations, were conducted using Gaussian 09, with ultra-fine integration grids and tight convergence criteria for the SCF procedure. Bond descriptors were computed utilizing ChemBOS, Multiwfn, and LModeA software, providing a robust and detailed examination of bond properties.
Investigation of Mechanical Properties of Kofke Stone Used in Historical Buildings in Isparta by Nondestructive and Destructive Methods
Authors: EVCİ PINAR USTA
Published: December 2023

The seismic behavior of historical buildings and possible damages that may occur in the structure can be determined by software such as finite element models. However, for an accurate simulation, the properties of masonry building materials should be determined with high precision. In many cases, it is inconvenient to conduct experiments that may destroy historical structures. Therefore, non-destructive methods are also needed to determine material properties. In this study, the mechanical properties of Köfke stone used in historical masonry buildings in Isparta province, many of which are still actively used, were investigated. Non-destructive and destructive methods were used in the investigation and these methods were correlated with each other. In the study, properties of kofke stone such as dry-unit volume mass, porosity, water absorption by mass, ultrasonic seismic velocity, Schmidt tensile strength, dynamic modulus of elasticity, compressive strength, splitting-tensile strength, static modulus of elasticity were determined. All tests were performed by the applicable national and international standards. The dry unit volume mass of Kofke stone is 1434 kg/m3, water absorption by mass is 18.5%, longitudinal seismic wave velocity (avg.) was 1806 m/s, Schmidt hammer strength was 17.6 MPa, dynamic modulus of elasticity was 4.85 GPa and Poisson's ratio was 0.19. In the destructive tests, the compressive strength was determined as 6.57 MPa, the splitting-tensile strength as 0.71 MPa, and the modulus of elasticity as 1.66 GPa. Empirical equations for the prediction of the compressive strength and static modulus of elasticity of kofke stone by non-destructive methods were also presented.
Research and Application of Fault Location Technology for T-Connection-Hybrid Transmission Lines
Authors: Qiu Long , Ai Yongheng , Liu Jianxing , Xie Cheng , Fu Han , Yan Yitao
Published: December 2023

Aiming at the problem of low reliability of fault location for existing T-junction-hybrid transmission lines, a method of fault location for T-junction-hybrid transmission lines based on distributed fault traveling wave location is proposed. Firstly, the basic principle of double-terminal traveling wave location is analyzed, and then the fault location method of T-junction line based on modulus time difference and the fault location method of overhead-cable hybrid line based on wave velocity normalization method are studied. Finally, the simulation model of complex transmission line including T-connection and overhead-cable hybrid frame is built, and two typical scenarios of T-connection branch fault and main line fault are simulated respectively. The results show that the fault location method proposed in this paper can achieve accurate fault location of T-connection-hybrid frame transmission line.
Current perceptions and demands of home pharmacy services: a survey of medical staff and community-dwelling patients in Shanghai of China
Authors: Zhang Xinyue , Tong Wai Kei , Xia Qian , TANG Zhijia
Published: December 2023

Background In response to the challenges posed by an aging demographic, China has recently embraced home pharmacy services. Our study aims to investigate the knowledge, attitudes, and demands of home pharmacy services in Shanghai, China, and pinpoint challenges from the vantage points of both healthcare providers and community-dwelling patientsMethod A cross-sectional questionnaire-based survey was conducted among medical practitioners in community health centers and residents within five districts of Shanghai, China from March–October 2022. The Chi-square test or Fisher's exact probability method was employed to assess the distributions of categorical variables across different groups. A logistic regression model was utilized to evaluate factors associated with demands for home pharmacy services.Result A total of 283 medical practitioners and 172 community-dwelling patients were included. They expressed positive attitudes but finite familiarity and confidence to home pharmacy services. Medication guidance/education was the top service, favored by 89.0% of practitioners and 83.1% of patients. Service providers varied, with 33.2% of practitioners preferring residents' self-governing organizations and 62.8% of patients favoring pharmacists in secondary and tertiary hospitals. Logistic regression highlighted age, professional role, and education significantly influence their demands. Preferences for home pharmacy service modalities differed significantly (P < 0.001), with practitioners leaning towards the "team mode" (39.6%) and patients preferring the "pharmacist-physician mode" (42.4%). Furthermore, 75.0% patients were willing to spend 50 RMB or less per visit, with those aged 60 or older (P < 0.001) and those with education below a bachelor's degree (P = 0.001) favoring payments of 10 RMB or less per visit.Conclusion Study revealed the discrepancy and disparity between service supply and demand. Common implementation challenges and diverse preferences emerged for home pharmacy services. Exploring larger sample sizes and personalized system designs for future research is recommended.
Machine learning-based integration develops multi regulated cell death-related signatures for improving outcomes and immune response in acute myeloid leukemia
Authors: Li Lin , Zhang Rui , Li Jinming
Published: December 2023

Acute myeloid leukemia (AML) presents an unpredictable and complex prognosis. Researchers have been exploring different ways to determine the death of cancer cells, including various forms of regulated cell death such as apoptosis, autophagy, cuproptosis, disulfidptosis, ferroptosis, necroptosis, panoptosis, and pyrotosis. However, there have been limited studies on combining these cell death modalities in AML. This study aimed to identify clinically relevant molecular classification of AML based on genes related to multiple programmed cell death signaling pathways. Machine learning techniques were used to identify these subtypes and provide guidance on medication for each subtype using transcriptome data. The subtypes differed in immune and drug response. A robust prognostic model MPCDPG was developed based on gene pairs and validated in multiple test sets. In conclusion, this study identified three clinically relevant subtypes of AML and developed a reliable prognostic model based on gene pairs regulated cell death-related genes.
Stakeholder perspectives on factors influencing acute care patient outcomes: A qualitative approach to model refinement
Authors: Ziemek Jessica , Hoge Natalie , Woodward Kyla F , Doerfler Emily , Bradywood Alison , Pletcher Alix , Flaxman Abraham D , Iribarren Sarah
Published: December 2023

Background: Health systems have long been interested in the best practices for staffing in the acute care setting. Studies on staffing often focus on registered nurses and nurse-to-patient staffing ratios. There are fewer studies on the relationship between interprofessional team members or contextual factors such as hospital and community characteristics and patient outcomes. This qualitative study aimed to refine a causal model by soliciting hospital stakeholder feedback on staffing and patient outcomes.
Methods: We conducted a qualitative study using semi-structured interviews and thematic analysis to understand hospital stakeholder perspectives and their experiences of factors that affect acute care inpatient outcomes. Interviews were conducted in 2022 with 38 hospital stakeholders representing 19 hospitals across Washington State.
Results: Findings support a model of characteristics impacting patient outcomes to include the complex and interconnected relationships between community, hospital, patient, and staffing characteristics. Within the model, patient characteristics are nested into hospital characteristics, and in turn these were nested within community characteristics to highlight the importance of setting and context when evaluating outcomes. Together, these factors influenced both staff characteristics and patient outcomes, while these two categories also share a direct relationship.
Conclusion: Findings can be applied to hospitals and health systems across the globe to examine how external factors such as community resource availability impact care delivery. Future research should expand on this work with specific attention to how staffing changes and interprofessional team composition can improve patient outcomes.
Towards a Dialogic Ethical Criticism:
Authors: Nah Dominic
Published: December 2023

Since the late 20th century, Literature educators have adopted dialogic pedagogies that connect aesthetic appreciation and other-centred approaches to literary texts. However, classroom research on students’ ethical meaning-making has rarely been connected with theoretical developments of ethical criticism or conducted in non-western contexts and classroom debate settings. To map how Literature classroom interactions open or close possibilities for ethical meaning-making, I propose a dialogic ethical criticism that synthesises an other-centred ethical criticism influenced by Emmanuel Levinas’ ethical philosophy and Hans-Georg Gadamer’s notion of hermeneutic conversation.
Using deductive and inductive analysis, I develop and apply a coding framework to examine classroom discourse in a high-ability Singapore Secondary Four (Grade 10) class in an Asian poetry unit. I focus on a series of classroom debates comparing poems with ethical invitations on the representations of asylum seekers, the process of embracing diversity, and reasserting identity amidst discrimination. While some students keenly consider others’ perspectives and develop the strength of their interpretive possibilities with close textual evidence, other students simulate an ethical openness by selectively using textual evidence. Although antagonistic forms of literary debates can inhibit students’ ethical meaning-making, student adjudicators providing constructive feedback with close textual support can facilitate responsible interpretive possibilities.
ASSESSMENT OF THE PREVENTION MEASURES EFFECTIVENESS FOR THE DEVELOPMENT OF CARIOUS DENTAL LESIONS IN MILITARY PERSONNEL OF THE ARMED FORCES OF UKRAINE
Authors: Lavrin Oksana
Published: December 2023

Introduction. The prevalence and severity of diseases of the teeth and oral cavity are directly dependent on the level of dental care. The specific living conditions and combat activities of the personnel of the Armed Forces of Ukraine, associated with the characteristics of the military profession, influence the course of pathological processes of the dentofacial apparatus and require appropriate methods of prevention and treatment.
The purpose of the research: to evaluate the effectiveness of measures to prevent the development of dental caries in military personnel of the Armed Forces of Ukraine.
Materials and methods. To conduct the study, 348 military personnel of the Ternopil zonal department of the Military Law Enforcement Service (TZDMLES) were examined; they underwent a clinical examination in order to identify carious dental damage. The intensity of caries was determined according to the CFE index, and the acid resistance of enamel was studied using the TER test.
After the initial examination, military personnel of all ages underwent complete sanitation of the oral cavity. According to indications, fissures were also opened and sealed. When enamel resistance was found to be decreased and initial forms of caries were present, patients underwent deep fluoridation of enamel and dentin. In order to optimize primary prevention measures for the development of major dental diseases for military personnel, we have developed an oral care program for the period of stay in the combat zone.
Results. When studying the prevalence of the carious process during the initial examination among military personnel of the TZDMLES, it was found that the prevalence of the carious process in this category of people was high: from 83.08% in the age group of 20 to 25 years to 100% in the age groups of 36 to 40 and 41 to 45 years. Indicators of the intensity of the carious process tend to increase among men and women in all age groups. After 12 months of observation, a decrease in the increase in the “C” index and a significant increase in the acid resistance of enamel was noted in all age groups examined.
Conclusions. When planning measures for the primary prevention of the development of carious lesions, it is necessary to take into account the peculiarities of the life of patients, which is especially reasonable for military personnel who are in the combat zone, and carry out preventive measures together with therapeutic ones in order to reduce the risk of developing major dental diseases and increase their combat effectiveness.
Productivity of the soft winter wheat cultivar ‘Duma Odeska’ depending on the characteristics of stubble tillage
Authors: Korkhova M. M. , Smirnova I. V , Nikonchuk N. V. , Makarchuk B. M.
Published: December 2023

Purpose. To determine the effect of surface soil tillage, carried out with the help of various agricultural machines, on its weediness, the intensity of decomposition of plant residues of winter barley and the yield of the next crop (winter wheat variety ‘Duma Odeska’).
Methods. General scientific, special, field, mathematical-statistical and computationalcomparative methods were used in the research.
Results. In the conditions of oversaturation of crop rotations and application of resource-saving cultivation technologies, the use of new tools for surface tillage with its simultaneous crushing, cutting of the root system of weeds and crop residues, their partial wrapping and mulching of the field surface is relevant. In 2021–2022, the greatest decomposition of winter barley stubble was observed 21 days after surface tillage with the DUCAT RST-6 rotary harrow – on average 5.1–6.5% higher values than when using the DUCAT UVT-6 vertical tillage harrow and the DUCAT-2.5 short disc harrow. The DUCAT RST-6 caused the highest weed and carrion seed germination (30–37 pcs/m2 ), the DUCAT-2.5 the lowest (13–18 pcs/m2 ). The highest grain yield of winter wheat of the variety ‘Duma Odeska’ (5.63 t/ha) in the years 2022–2023 was achieved by surface stubble cultivation with the DUCAT-2.5 implement.
Conclusions. According to the results of the conducted researches it was established that the stubble tillage with the rotary harvester DUCAT RST-6 immediately after the harvest of the preceding crop (winter barle) is the most favourable for the germination of carrion and weed seeds.
On the Question of the Concept, Essence and Types of Administrative Procedures of the State Registration of Civil Status Acts
Authors: Banakh Serhii
Published: December 2023

The article is devoted to the consideration of issues related to the definition of the concept of administrative procedures of state registration of civil status acts and the main criteria for its division. The relevance of the topic is determined by the fact that the leading place in the system of providing administrative procedures belongs to the institute of state registration of acts of civil status, which is carried out by various subjects of public administration on the basis of the norms of administrative law. Increasing attention to the problem of defining, streamlining and proper legal regulation of various procedures is due to the complexity and diversity of management, regulatory and control activities of public authorities. The purpose of the article is to define the concept of administrative procedures for state registration of acts of civil status and to highlight the main criteria of their types. Achieving the outlined goal became possible thanks to the use of a complex of methods of scientific knowledge, namely: the dialectical method, the logical-semantic, structural-functional method and the method of interpreting legal norms. Scientific positions on the interpretation of the essence of the concept of "administrative procedure" have been analyzed. On the basis of the conducted theoretical analysis, it was concluded that scientists are united by the thesis that the administrative procedure is directly related to the activity of public administration and is an established algorithm for the functioning of subjects of power (state authorities, local self-government bodies, their officials and officials, etc.). It is substantiated that the most convincing is the recognition of the administrative procedure as a complex normative regulator of the system of administrative-procedural norms, which determine the procedure for the implementation of certain types of actions by administrative bodies regarding the application of standardized administrative-legal measures as normatively fixed methods and techniques for the performance of state functions entrusted to these bodies . Attention is paid to the study of issues of classification of administrative procedures of state registration of acts of civil status according to separate criteria, distinguished by their own characteristics. On the basis of the conducted research, conclusions were formulated and recommendations were made for establishing at the legislative level the types of administrative procedures for state registration of civil status acts, grouped according to the relevant criteria.
Isolation of curcumin compounds in Temulawak Rhizome (Xanthorrhiza Roxb)
Authors: Ramandha Muhammad Eka Putra , Kresnapati I Nyoman Bagus Aji
Published: December 2023

The curcumin compounds in Temulawak Rhizome have been isolated and identified.. This study aims to identify curcumin compounds in temulawak rhizome by modifying methods that pay attention to the efficiency of funds and the use of materials. In general, the method of isolation and identification is carried out. The methods used are (1) Extraction, (2) Thin Layer Chromatography, (3) Column Chromatography and (4) Infrared (IR) Testing. Based on comparing the sample's Retention Factor (RF) value with the standard curcumin compound, the results were identical, and the positive sample contained a curcumin compound. The results of the Infrared spectrum can be assumed that the sample is a flavanols group, which can be seen from the wavelength range of identical functional groups in curcumin compounds.
Experimental Methods for Membrane Applications in Desalination and Water Treatment
Authors: Salinas-Rodríguez Sergio G. , Villacorte Loreen O.
Published: December 2023

Water quality is a critical issue for the water industry today, and membrane fi ltration a highly effective treatment used to provide clean water for the global population. Experimental processes and methods are being developed for assessing fouling, scaling, performance and modelling of membrane systems, and research is needed to further improve the sustainability and feasibility of these technologies, and to mitigate the challenges of water scarcity for billions of people, particularly in developing countries.

This book aims to address this vital issue by bringing together experts in the fi eld to share their learning, including: Membrane processes: microfi ltration (MF), ultrafi ltration (UF), reverse osmosis (RO), forward osmosis (FO) and membrane distillation (MD)Particulate fouling: silt density index (SDI), modifi ed fouling index (MFI-0.45 and MFI-UF)Inorganic fouling and scaling: assessment, characterization tools and mitigationOrganic fouling: size exclusion chromatography (LC-OCD), fl uorescence spectroscopy (FEEM) and transparent exopolymer particles (TEP)Biological fouling: genomic tools, bacterial growth potential (BGP) of seawater and low-nutrient water and optical coherence tomography (OCT)General applications: membrane autopsy and computational fl uid dynamics (CFD) modelling
Effectiveness and health risk assessment of drinking water from different sources treated by local household water treatment methods in Bamenda, Cameroon
Authors: Nkwatoh Therese Ncheuveu , Yakum Benard Mingo , Itor Paul Oto Beseka
Published: December 2023

This study accessed the efficiency and health risks of drinking water from different sources treated by filtration, boiling, chlorination, flocculation, and solar disinfection. The microbial quality of 45 treated water samples from boreholes, wells, and pipe-borne water was analyzed to determine treatment effectiveness and to quantify risk using quantitative microbial risk assessment. The effectiveness of each treatment method was a function of sampling sources (p < 0.05) and location (p < 0.10), chlorination and boiling being the most efficient methods (100%). Shiegella in well water samples treated by filtration and flocculation had the highest daily infection risk of 69.5 × 10−1 and 67.5 × 10−1 pppd. The annual risk of infection from Salmonella, Shigella, and Staphylococcus ranged from 7.8 × 10−1 to 1.00 pppy, exceeding the U.S. EPA annual infection benchmark (≤10−4 pppy). Salmonella, Shigella, and Staphylococcus had the highest risk of illness of 4.50 × 10−1, 3.30 × 10−1, and 9.80 × 10−1, respectively. All disease burden values exceeded the WHO disease burden benchmark (≤10−6 DALYs/pppy), with Staphylococcus and Salmonella contributing the highest disease burden of 4.71 × 10−2 and 2.13 × 10−2, DALYs/pppy. Therefore, boiling and chlorination are the best disinfection methods for the pathogens tested.
Problem ograniczenia indywidualnej wolności sumienia i religii w małżeństwach mieszanych
Authors: Pietrzak Helena
Published: December 2023

W artykule podjęto analizę problematyki okoliczności skutkujących narusze- niem lub ograniczeniem wolności sumienia lub wyznania w aspekcie indywidualnym. Autorowi opracowania zależy na osiągnięciu postawionych celów badawczych poprzez analizę ogólnych założeń Dekretu Generalnego Episkopatu Polski z roku 2020. W ramach opracowania wzięto pod uwagę obszar naruszeń wolności sumienia przez małżonka w kontekście małżeństwa mieszanego (kwestie zmiany wyznania, utrudniania praktyk religijnych). W ramach indywidualnej ochrony wolności sumienia i wyznania analizo- wano także procesy kanoniczne, w szczególności – procesy małżeńskie. Tym bardziej, że kwestia sumienia i wyznania jest brana pod uwagę z urzędu w toku procesu małżeńskiego.
The ecclesiastical discipline of the celebration of marriage according to the books of the Roman Rite of 1962 after the Second Vatican Council according to the motu proprio Summorum Pontificum and Traditionis custodes
Authors: Pietras Dawid
Published: December 2023

Through Pope Benedict XVI’s motu proprio Summorum Pontificum of July 7, 2007, the universal law for use of the 1962 liturgical books entered into force, but under certain conditions. Bishops received the unrestricted right to use the Pontificale Ro- manum of 1961/62 in the celebration of marriage. Nevertheless, the use of the Rituale Romanum of 1952 by priests or deacons when assisting at marriages required the per- mission of the parson or rector of the church hosting the ceremony. In addition, mem- bers of the clergy whose communities received the special permission necessary from the Apostolic See or the local Ordinary could also participate as qualified witnesses in a marriage ceremony celebrated according to the earlier rites. However, since July 16, 2021, after the issuance of the motu proprio Traditionis custodes, celebrating a marriage according to the books of 1962 is only possible in personal parishes with the permission of the diocesan bishop. The local Ordinary can also authorise priests of communities that have the special right to celebrate the earlier rites to celebrate such marriages. During the celebration of marriage according to the books of 1962, the current Code’s discipline should be maintained, providing it does not violate the shape of the rites contained in these books.
Elaboração da interpretação automática de fraturas nos perfis de imagem utilizando a Inteligência Artificial
Authors: Almeida Conrado Victoria , Gomes dos Santos Ribeiro Mariléa
Published: December 2023

A Inteligência Artificial (IA) é uma abordagem de processamento de dados que utiliza análise de informações, detecção de padrões e prognósticos com pouca intervenção humana. O campo da IA ​​abrange diversos subconjuntos, com destaque para o aprendizado de máquina (Machine Learning - ML), que possui grande potencial na indústria de petróleo e gás, especialmente na análise e interpretação de dados. Algoritmos de ML, como Support Vector Machine (SVM), Redes Neurais Artificiais (RNA), Deep Learning (DL) e Algoritmos Genéticos (AG), têm sido aplicados com sucesso na indústria petrolífera. A indústria de petróleo enfrenta desafios tecnológicos significativos, dada a sua complexidade. A análise de formação geológica por meio de perfilagem é crucial para melhorar a avaliação das formações rochosas, minimizar danos e reduzir custos na perfuração de poços. Além disso, a identificação de fraturas naturais e induzidas é fundamental para entender os reservatórios, especialmente os não inoportunos. O estudo das fraturas pode ser dividido em aspectos qualitativos e quantitativos, que envolve a identificação e a análise detalhada das fraturas nos reservatórios. A IA, especialmente o ML, pode ser aplicada para analisar a geometria, orientação, densidade e complexidade das fraturas, classificando-as em diferentes tipos, como fraturas induzidas e naturais. O objetivo deste estudo consiste em automatizar a interpretação de falhas em perfis de imagem por meio do uso de Inteligência Artificial, aprimorando a eficiência, a precisão e a velocidade desse procedimento. A linguagem de programação Python e a ferramenta Jupyter Notebook foram utilizadas para desenvolver o programa de IA. Foram coletados dados e imagens, que foram processados ​​e analisados ​​usando bibliotecas como OpenCV, Numpy e Sklearn.svm. Os resultados obtidos demonstram a eficácia da IA ​​na identificação de fraturas em diferentes tipos de perfis de imagem, incluindo imagens acústicas, de resistividade, e de outras ferramentas de perfilagem. A Inteligência Artificial conseguiu identificar com precisão fraturas naturais, fraturas de baixa amplitude, fraturas internas e outros eventos geológicos. No entanto, o sucesso da IA ​​depende da qualidade e quantidade dos dados de treinamento, e desafios como a complexidade geológica e a resolução das imagens ainda precisam ser superados. A aplicação da IA na interpretação automática de fraturas em imagens na indústria de petróleo oferece melhorias significativas na eficiência e rapidez do processo, contribuindo para a compreensão das características das formações rochosas.
Bioinformatics and Application of Computers
Authors: Kharb Simmi , Singh Akshat , Singh Abhyuday , Kharb Deepa
Published: December 2023

Bioinformatics applications are effective in generating the vast quantity of inputs. Term simulation is the computation for developing algorithms and software, construction of database and curation, and analysis of gene sequence, functions, and structures. Understanding of genetic control of complex dynamic traits has fundamental importance in research fields of agriculture, evolution, and biomedical genetics. The advances in bioinformatics tools have changed research in both basic and applied biological sciences and these tools are enabling scientists to gain knowledge of complex biological systems. Also, they allow implementation of results towards novel developments in biomedical applications and contribute to promoting both individual and population welfare.
Tubulin Modifying Enzymes as Target for the Treatment of Alzheimer's Disease: Old Perspective With A New Angle
Authors: Shrivastava Shweta , Kumar Ayush , Kumar Jeengar Manish , Sahu Chandraprabha
Published: December 2023

Alzheimer's disease (AD) is a major cause of mental disability in the elderly,
accounting for 50-60% of all dementia. While β-amyloid plaques as well as
neurofibrillary tangles are neuropathological markers, inflammation plays a critical role
in AD development. The aberrant detachment of microtubules (MTs) from axon MTs,
cellular mislocalization, and hyperphosphorylation of tau are major factors in
neurodegeneration death. Tau's ability to aggregate as well as form NFTs is assumed to
be regulated by post-translational changes, which are regarded to be an essential
regulatory mechanism. So far, drugs that target tau phosphorylation as well as
aggregation have not shown therapeutic impact. It is now clear that tubulin PTMs cause
tau dysfunction. High glutamylation and detyrosination levels in the neurons affect MT
surface physicochemical characteristics. Further evidence for the relevance of such an
enzymatic machinery in neurobiology comes from the recent discovery of harmful
mutations in enzymes involved in surface MT modification. In this chapter, we
discussed that targeting tubulin-modifying enzymes pharmacologically may be useful
in treating neurodegenerative disorders.
Novel Treatment for Alzheimer’s Disease: Tapping the Somatostatin-evoked Aβ Catabolism via α-endosulfine-KATP Channel Pathway
Authors: Varghese Ryan , Digholkar Gargi , Deshpande Abha , Kumar Dileep
Published: December 2023

Alzheimer's disease (AD) is a debilitating neurological disease that is known to worsen as people age. As a chronic illness, it has a negative impact on the health and financial well-being of patients and their families. Despite decades of research into new medications and therapy regimens, the therapeutic choices for these conditions are still limited. Although currently available medications for AD do not prevent or stop disease progression, they are used to treat symptoms and provide brief comfort to patients. The development of medications and other therapy modalities to address the unmet medical need has sparked a surge of interest in understanding the mechanism of AD in recent years. Growing bodies of evidence direct towards the treatment of AD by intercepting the Somatostatin-evoked Aβ catabolism in the brain, via the α-endosulfin-KATP channel pathway. The latter can be achieved through the repurposing or repositioning of drugs previously approved by the regulatory authorities and indicated in other diseases. With the advent of technology in the healthcare sector, these could be corroborated through various in-silico and in-vitro techniques. This article aims to explore the various aspects of the byzantine α-endosulfine-KATP channel pathway while providing information and future prospects for the development of new therapies to combat AD.
Metallic Nanoparticles: Synthesis and Applications in Medicine
Authors: Akay Şeref , Eda Kuş Sultan
Published: December 2023

The progress in nanoscience and advances in the fabrication,
characterization, and modification of materials at the nanoscale have paved the way for
the production and use of nanoparticles with different properties. Today, the chemical
agents used in many therapies cannot achieve the desired effectiveness due to dose-dependent toxicity, low solubility and bioavailability, damage to non-target organs and
tissues due to non-specificity, and side effects. Nanoparticle systems produced in
different forms and compositions are one of the main approaches used to eliminate the
negative aspects of conventional chemical agents. Among these nanoparticle systems,
metallic nanoparticles represent a promising approach. During the last two decades,
metallic nanoparticles (MNPs) have drawn great attention due to their optical,
electrical, and physicochemical properties as well as their size-dependent properties.
The large surface to volume ratio and surface reactivity of metallic nanoparticles
provide great potential for combining them with different biological/chemical agents,
as well as they can also be formulated as a bioactive nanoplatform alone. In this regard,
the present chapter summarizes the general aspects of metallic nanoparticles, common
methods for synthesis, and various applications in the biomedical field.
Photodynamic Therapy and Applications in Cancer
Authors: Sarı Ceren , Celep Eyüpoğlu Figen
Published: December 2023

 The idea of using light as a therapeutic tool has been popular for thousands
of years. Scientific discoveries in line with technological innovations have contributed
to the advancement of photodynamic therapy as a therapeutic modality. Photodynamic
therapy is based on the generation of highly reactive species that alter the molecular
systematics of cells through interactions between light, photosensitizer, and molecular
oxygen. It has a minimally invasive protocol that can be combined with other clinical
methods or can be stand-alone. The development of photosensitizers with the
integration of nanotechnological approaches has provided favorable results over the
years in malignant and non-malignant diseases by facilitating target-site action,
selectivity, and controllable drug release. This chapter presents a review of
photodynamic therapy with its important aspects; history, mechanism of action, cellular
effects, integration into nanoscale drug delivery systems, and combinational therapeutic
approaches in cancer. 
Biosynthesis and Function of Glycoconjugates
Authors: Bakar Elvan , Pelin Türker Nebiye , Erim Zeynep
Published: December 2023

Investigations to ascertain the physiological roles of carbohydrates in
biological systems are being given more importance each day. Basically, carbohydrates
are biomolecules with a wide range of biological functions, although they represent the
primary energy source for metabolic processes. Carbohydrates are found as structural
components in connective tissue in animal organisms. They also act as structural
elements in both plant and bacterial cell walls. In the cell, they bind to lipids and
proteins to form glycoconjugates called glycolipids, glycopeptides, glycoproteins and
peptidoglycans. By binding to lipids and proteins on the cell surface, they perform as
molecules that support intercellular adhesion and intercellular communication.
Glycobiology is the science that investigates the structure, biosynthesis, and impacts of
glycans on biological functions. In biology, glycoconjugates serve a variety of key
roles. In mammalian cells, the majority of proteins are glycosylated, and this explains
how proteins perform their various functions. In the future, these techniques will be
crucial for the identification and treatment of specific diseases. The most major area of
progress in glycobiology is the development of carbohydrate-based medicines.

Some diseases, including cancer, can be diagnosed via altered cell surface
glycosylation pathways as a biomarker. Therefore, regulating glycosylation mechanisms and understanding the phenotypic characteristics of glycoconjugates are crucial
steps in the design of novel strategies.

This chapter discusses the biosynthesis of glycoconjugates, their wide range of
biological functions, and their significance for therapy
Ergonomics in Laparoscopy
Authors: Yeola (Pate) Meenakshi , Nayak Sushanth R.
Published: December 2023

Ergonomics studies aptly fitting a worker to his job or how the environment is more conducive to a laparoscopic surgeon. In 1949, the phrase was fully defined and benefited and protected many aspects of human activity [1]. In the context of laparoscopy, the importance of ergonomics cannot be overstated. Suturing time can be reduced by using proper ergonomics, according to studies [2]. Ergonomically designed items have been found to alleviate pressure-related chronic discomfort in surgeons [3]. This article discusses fundamental principles and procedures such as triangulation, ideal coaxial alignment, doctor-patient drawbacks, and how to forego these challenges with recent technological breakthroughs.
Instruments for Access
Authors: Lamture Deepak , Yeshwant Ramrao Lamture , Gajbhiye Varsha P.
Published: December 2023

Laparoscopy has emerged as a spin-off to technological advancement in the
field of general surgery that not only aims to minimize the operative trauma to the
patient but also to consummate the surgical endpoint. It has succeeded in curtailing the
length of scars over the patient thus being able to bring less disfigurement to the
patient. It has proven frugal to the patients as it reduces the operative period, and stay
in the hospital and eases comparatively early resumption of the work. It has taken the
edge off the psychological trauma the patient undergoes, thus adding to better surgical
outputs. The long learning curve and the intraoperative complications including
bleeding have proven arduous but the adoption of new technology has succeeded to
master these complications. 
Ömer Çaha nın Sivil Kadın: Türkiye de Kadın ve Sivil Toplum Adlı Eserinin Değerlendirilmesi
Authors: Polat Pınar
Published: December 2023

Bu çalışmada, Ömer Çaha tarafından yazılan Sivil Kadın: Türkiye’de Kadın ve Sivil Toplum kitabının değerlendirmesi yapılmaktadır. Yazarın doktora tez çalışmasını daha sonra güncel kadın sorunlarını ve bu konudaki gelişmeleri de ekleyerek genişlettiği çalışması, dönemlere ve tüm kadın hareketlerine temas etme gayretiyle öne çıkmaktadır. Çaha’nın yaklaşık otuz yıllık emeğinin ürünü olan, İngilizce’ye de çevrilen ve ulusal, uluslararası düzeyde geniş ilgi gören kitabında, kadınların Batı’daki “Lanetli Havva” kabulünden günümüze kadar tüm edinimleri, adeta bir “pembe devrim” olarak nitelendirilmektedir. Kitap, kadın hareketlerinin günümüze kadarki serüvenine değinmekte ve bu konuda çalışma yapmak üzere yola çıkacaklara, Türkiye’deki kadın hareketi ve sivil toplum ilişkisinin gelişimine dair objektif bir kaynak oluşturmaktadır.
Leadership Lessons from Indian Knowledge System
Authors: Sathish M. , Bhat Vinayak Rajat , M. Satheesh Varma , Balasudarsun N. L.
Published: December 2023

In a Volatile, Uncertain, Complex and Ambiguous (VUCA) world efficiently managing the human resources is highly challenging for this era leaders. Leadership is a powerful enabler that can leverage an organisation to any heights. But bad leadership can downside any organization which leads to destruction. To lead the organization effectively and efficiently leaders follow different types of leadership styles. So, one of the critical challenges is leading the organization and driving towards his vision. Therefore, one of the major issues and the real concern of any organization is identifying great leaders and nurturing the best qualities. Several theories were discussed and deliberated this issue from a multiple perspective. So many different qualities and styles of leadership have been discussed in modern management theories. The interesting observation is our ancient scriptures such as Bhagavad Gita, Mahabharata, Ramayana, Arthashastra and Bhoja Prabandha etc., we get different perspectives of what leadership is and what it can do to an organization. For Instance, Lord Krishna who was the avatar of Lord Vishnu who was a divine soul with a high degree of intelligence, communication skills and ability to influence others and capable of resolving any crises faced by his devotees. In the modern scenario, it can be said that Lord Krishna has acted as the greatest crises manager the world has ever produced. If we look towards Mahabharata, we can say that Krishna was the Finest Strategist. Even though many other characters in Mahabharata have responded to the great challenges at that time. Krishna was also a thoughtful and intelligent leader he adopted different leadership style according to the time; people and situation. Majorly this paper focus on how our Indian ancient scriptures such as Bhagavad Gita, Mahabharata and Ramayana had different perspectives on leadership qualities.
A Spiritual Sojourn Unveiled: Precious Moments with Acharya Saumyendra Nath Brahmachary
Authors: Kumar Dinesh , Sinha Amit Kishore , Singh Divyanshu
Published: December 2023

This article is a trans-creation of a long and intimate interview of Gurudev Shrimat Saumyendra Nath Brahmachary (1946-2012), former Acharya, DevSangha, Deoghar. An attempt has been made to understand life and experiences of a monk and to understand views on spiritualty, religion and modern generation from a spiritual leader. Further, efforts have been made to understand the functioning of the spiritual organization.