bluuebunny/crossref_metadata_2025 huggingface dataset:
The Use of Multiple Imputation to Handle Missing Data in Secondary Datasets: Suggested Approaches when Missing Data Results from the Survey Structure
Authors: Jo Soojung
Published: May 2022

Secondary datasets are used in healthcare research because of its cost advantages, its convenience, and the size of the datasets. However, missing data can cause problems that are difficult to resolve. This manuscript reviews possible causes for missing data, and how to address them. Many researchers use multiple imputation as a solution, which consists of three phases: (a) the imputation phase, (b) the analysis phase, and (c) the pooling phase. When missing data is caused by a refusal to answer or by insufficient knowledge, multiple imputation works well. However, difficulties arise when there are problems with screening questions. If respondents do not answer a screening question, possible answers could be either “yes” or “no.” This paper suggests identifying “yes” responses on the screening question, and setting them aside for use in the analysis. The reasons for this approach are the impossibility of conducting multiple imputation twice, the problem of imputation based on the population after sample weight, and the difficulty of producing logical errors on the estimation in imputation phase. This manuscript uses as an example the techniques used to address missing data from screening questions in a national US dataset. These techniques of multiple imputation using examples from the dataset could be used by researchers in future healthcare research that relies on secondary datasets.
Looking back to move forward: a scoping review of counselling psychology in South Africa
Authors: Haine Phillipa , Young Charles , Booysen Duane D
Published: May 2022

Despite that counselling psychologists represent a substantial group of registered psychologists in South Africa, literature specifically on the sub-speciality within the country is limited. The aim of this scoping review was to provide a comprehensive summary of the literature available on counselling psychology in South Africa and examine the extent to which literature is available from a lifespan or career-stage perspective. Three electronic databases (EBSCOhost, Sabinet®, and PubMed) were searched for articles published between 2000 and 2021. Titles and abstracts were reviewed, and data extracted and synthesised thematically. Of 507 citations identified, 10 met the inclusion criteria. Findings indicate that literature on counselling psychology in South Africa is scarce, subject to methodological limitations, and dominated by a small number of authors conducting multiple analyses on the same sets of data. Furthermore, literature on counselling psychologists at key career stages across the professional lifespan is largely missing from the professional discourse. Emphasis is instead placed on counselling psychology as embedded in the sociopolitical history of South Africa, professional identity, the contemporary status of the profession, professional threats and challenges, and the profession’s future promise. Our review highlights the need for more empirically informed studies making use of different methodologies, involving multiple authors with diverse backgrounds, tracking employment trends, and soliciting first-person accounts of counselling psychologist’s experiences at key career stages. Without doing so, ideas about how best to support and utilise this particular group of practitioners may be misguided, in turn compromising the successful provision of mental health care within the country.
Impact on emergency and elective hospital-based care in Scotland over the first 12 months of the pandemic: interrupted time-series analysis of national lockdowns
Authors: Shah Syed Ahmar , Mulholland Rachel H , Wilkinson Samantha , Katikireddi Srinivasa Vittal , Pan Jiafeng , Shi Ting , Kerr Steven , Agrawal Uktarsh , Rudan Igor , Simpson Colin R , Stock Sarah J , Macleod John , Murray Josephine-LK , McCowan Colin , Ritchie Lewis , Woolhouse Mark , Sheikh Aziz
Published: May 2022

Objectives

COVID-19 has resulted in the greatest disruption to National Health Service (NHS) care in its over 70-year history. Building on our previous work, we assessed the ongoing impact of pandemic-related disruption on provision of emergency and elective hospital-based care across Scotland over the first year of the pandemic.

Design

We undertook interrupted time-series analyses to evaluate the impact of ongoing pandemic-related disruption on hospital NHS care provision at national level and across demographics and clinical specialties spanning the period 29 March 2020–28 March 2021.

Setting

Scotland, UK.

Participants

Patients receiving hospital care from NHS Scotland.

Main outcome measures

We used the percentage change of accident and emergency attendances, and emergency and planned hospital admissions during the pandemic compared to the average admission rate for equivalent weeks in 2018–2019.

Results

As restrictions were gradually lifted in Scotland after the first lockdown, hospital-based admissions increased approaching pre-pandemic levels. Subsequent tightening of restrictions in September 2020 were associated with a change in slope of relative weekly admissions rate: –1.98% (–2.38, –1.58) in accident and emergency attendance, –1.36% (–1.68, –1.04) in emergency admissions and –2.31% (–2.95, –1.66) in planned admissions. A similar pattern was seen across sex, socioeconomic status and most age groups, except children (0–14 years) where accident and emergency attendance, and emergency admissions were persistently low over the study period.

Conclusions

We found substantial disruption to urgent and planned inpatient healthcare provision in hospitals across NHS Scotland. There is the need for urgent policy responses to address continuing unmet health needs and to ensure resilience in the context of future pandemics.
Decreasing Incidence of Chemosensory Changes by COVID‐19 Variant
Authors: Coelho Daniel H. , Reiter Evan R. , French Evan , Costanzo Richard M.
Published: May 2022

Anecdotal clinical observation suggests that rates of chemosensory dysfunction associated with COVID‐19 infection may be decreasing. To investigate, the National COVID Cohort Collaborative database was queried for all patients with and without smell and taste loss within 2 weeks of COVID‐19 diagnosis. Six‐week periods of peak variant prevalence were selected by using CoVariants.org for analysis. Of 3,678,214 patients with COVID‐19 in the database, 616,318 met inclusion criteria during the time intervals of interest, with 3431 having an associated smell or taste disturbance diagnosis. With the initial/untyped variant set as the baseline, the odds ratios for alpha, delta, and omicron (December 27, 2021–February 7, 2022) were 0.50 (95% CI, 0.45‐0.55; P < .0001), 0.44 (95% CI, 0.41‐0.48; P < .0001), and 0.17 (95% CI, 0.15‐0.18; P < .0001), respectively. These data strongly support the clinical observation that patients infected with more recent variants are at a significantly lower risk of developing associated chemosensory loss.
The Effect of Civilian Oversight on Police Organizational Performance: A Quasi-Experimental Study
Authors: Kim Jisang
Published: May 2022

Although civilian oversight has been introduced to make the police accountable to citizens and perform better, its effectiveness has not been thoroughly investigated yet. To better understand civilian oversight of the police, this study explores its theoretical basis as an accountability mechanism and suggests how it holds police agencies accountable even without direct disciplinary authority. The data from Law Enforcement Management and Administrative Statistics (LEMAS) survey, the Uniform Crime Report (UCR) program, and the Fatal Encounters (FE) database are analyzed to estimate the effect of civilian oversight on police organizational performance, using a propensity score matching analysis. Among the dependent variables included in the analysis as performance indicators, civilian oversight turns out to have a significant influence only on police agencies’ clearance rates. The police agencies with civilian oversight have lower clearance rates by 2.71 percentage points on average compared to those without civilian oversight. The implications of civilian oversight's negative impact on police organizational performance are further discussed.
CT after emergency surgery in penetrating trauma: a seven-year experience in a level I Nordic trauma center
Authors: Halldorsson Kolbeinn , Nummela Mari , Thorisdottir Sigurveig , Oladottir Gudrun , Koskinen Seppo
Published: May 2022

Background

Patients with severe penetrating trauma may require emergency surgery on arrival, and postoperative computed tomography (CT) can reveal significant additional injuries.

Purpose

To determine the utility of postoperative CT performed within 48 h of emergency surgery after penetrating trauma.

Material and Methods

Trauma registry data were retrieved over a seven-year period at a single level 1 trauma center. All patients aged ≥17 years, admitted with penetrating injury, who underwent urgent surgery and postoperative CT imaging within 48 h, were included. Pre- and intraoperative medical records were compared to CT findings. Age, sex, Injury Severity Score (ISS), New Injury Severity Score (NISS), 30-day mortality, injury mechanism, surgical intervention, and intensive care unit length of stay were extracted.

Results

Out of 1262 patients, 38 fulfilled the study criteria (36 men [94.7%], 2 women [5.3%]; mean age = 31.5 years. Stab wound (SW) was the most common injury mechanism (26/38, 68.4%) followed by gunshot wound (GSW; 10/38, 26.3%). Patients with GSWs were more severely injured than SW victims (median NISS = 34 [range = 3–75]; for GSWs = 34; for SWs = 26; P = 0.045). Out of 38 patients, 20 (52.6%) had additional findings at postoperative CT. Six patients (15.8%) had unidentified or underestimated findings at CT that were severe enough to warrant additional surgery or angiography.

Conclusion

Postoperative CT imaging after emergency surgery in penetrating trauma is an important tool in evaluating the injury panorama. Out of 38 patients, 6 (15.8%) had findings at postoperative CT that warranted additional surgical or angiographic intervention.
Laryngeal and hypopharyngeal squamous cell carcinoma: association between quantitative parameters derived from dual-energy CT and histopathological prognostic factors
Authors: Geng Di , Chen Xi , Zhao Xing-Guo , Xu Xiao-Quan , Su Guo-Yi , Zhou Yan , Chen Hai-Bing , Wu Fei-Yun
Published: May 2022

Background

Dual-energy computed tomography (DECT) can provide objective evaluation of laryngeal and hypopharyngeal squamous cell carcinoma (LHSCC).

Purpose

To investigate the relationship between quantitative parameters acquired from DECT and histopathological prognostic factors in LHSCC.

Material and Methods

A total of 65 patients with LHSCC who underwent arterial phase and venous phase DECT scans were retrospectively enrolled. Iodine concentration (IC) and normalized IC (NIC) of the tumor were calculated in both the arterial (ICA and NICA) and venous (ICV and NICV) phases, and compared among different pathological grades, T stages, and lymph node stages. Receiver operating characteristic (ROC) curves were generated to evaluate their diagnostic performance.

Results

There were significantly differences on ICA and NICA among three pathological grades (ICA, P = 0.001; NICA, P = 0.002). For differentiating moderately and poorly differentiated from well-differentiated LHSCC using ICA and NICA, the areas under curve (AUCs) were 0.753 and 0.726, respectively. High T stage (T3/4) LHSCC showed significantly higher ICA ( P = 0.012) and NICA ( P = 0.005) than low T stage (T1/2) LHSCC. The AUCs of the ICA and NICA were 0.674 and 0.703, respectively, in discriminating high from low T stage LHSCC. Lymph node metastasis (LNM)-positive (N1/2/3) LHSCC showed significantly higher ICA ( P = 0.008) and NICA ( P = 0.003) than LNM-negative (N0) LHSCC. For discriminating the LNM-positive from the LNM-negative group using ICA and NICA, the AUCs were 0.697 and 0.744, respectively.

Conclusion

ICA and NICA might be helpful in assessing histopathological prognostic factors in patients with LHSCC.
An outbreak of systemic chlamydiosis in farmed American alligators (Alligator mississippiensis)
Authors: Carossino Mariano , Nevarez Javier G. , Sakaguchi Kanako , Paulsen Daniel B. , Langohr Ingeborg M. , Strother Keith , Ferracone Jacqueline , Roy Alma , Crossland Nicholas A. , Del Piero Fabio
Published: May 2022

Chlamydia spp are reported to causes systemic disease in a variety of hosts worldwide including few reports in crocodilians. Disease presentations vary from asymptomatic to fulminant disease, some of which are zoonotic. The aim of this study was to describe the pathological, immunohistochemical, and molecular findings associated with the occurrence of a previously unreported Chlamydia sp infection causing a major mortality event in farmed American alligators ( Alligator mississippiensis). The outbreak presented with sudden death in juvenile alligators mainly associated with necrotizing hepatitis and myocarditis, followed by the occurrence of conjunctivitis after the initial high mortality event. The widespread inflammatory lesions in multiple organs correlated with intralesional chlamydial organisms identified via immunohistochemistry and confirmed by 23S rRNA-specific real-time quantitative polymerase chain reaction (qPCR) for Chlamydiaceae bacteria. By sequencing and phylogenetic analysis of the OmpA gene, this uncultured Chlamydia sp grouped closely with Chlamydia poikilothermis recently described in snakes. This study highlights the significance of such outbreaks in farmed populations. Enhanced epidemiological monitoring is needed to gain further insight into the biology of Chlamydia sp in alligators, disease dynamics, risk factors, and role of carrier animals.
Body scan meditation enhances the autonomous sensory meridian response to auditory stimuli
Authors: Glim Sarah , Braun Lynn , Hayd Sophie , Kuenz Amelie , Rosak Felicitas , vom Bruch Jule
Published: May 2022

Autonomous sensory meridian response (ASMR) is a pleasant, tingling sensation on the skin that can be elicited by certain auditory and visual stimuli, with the intertwining of sensory modalities and emotional reactions observable in this phenomenon resembling that of synesthesia. The current study shows that the perception of ASMR-associated tingles can be enhanced by means of a prior mindfulness exercise in which attention is drawn to the body. This finding contributes to a better understanding of the crossmodal mechanisms behind ASMR and emphasizes the role that attentional processes play in its unfolding.
The Greentown Project: Building Evidence to inform Intervention Design for Juveniles Caught-up in Local Criminal Networks
Authors: Naughton Catherine M. , Redmond Sean , O’Meara-Daly Eoin
Published: May 2022

A small minority of juveniles are responsible for the majority of detected juvenile crime in Ireland. This situation presents significant policy concerns. The current paper, based on findings from a comparative analysis builds on a multi-step research design process to provide evidence-based knowledge to inform the design of a new targeted intervention. An initial social network analysis of national crime and intelligence data produced localized basic criminal network maps illustrating co-offending and intelligence relationships between adults and juveniles in specific Police sub-districts (Part 1). These network maps then provided an enquiry frame for interviews with members of the police forces in three case study locations (Part 2). A comparative analysis of the three studies (Part 3) identified diversity in network structure and inherent resilience. The analysis also identifies core similarities in juveniles’ vulnerabilities and risks to recruitment. These factors are important considerations for an intervention seeking to disrupt networks and create safe “exit” environments for juveniles.
Impact on the Nutritional and Functional Status of Older Mexican Adults in the Absence of Recreational Activities due to COVID-19: A Longitudinal Study From 2018 to 2021
Authors: Bricio-Barrios Jaime Alberto , Ríos-Silva Mónica , Huerta Miguel , Cárdenas-María Rosa Yolitzy , García-Ibáñez Alondra Elizabeth , Díaz-Mendoza María Guadalupe , Jiménez-Leal Héctor Mariano , Chávez-Torres Liz Argelia , Islas-Piza Liliana , García-García Shelem , Toro-Equihua Mario del , García-Rodríguez Ricardo , Carrazco-Peña Karla Berenice , López-Alcaraz Fátima , Trujillo Xóchitl
Published: May 2022

A longitudinal study, from 2018 to 2021, identified impacts on the nutritional and functional status of older adults when face-to-face activities at a social assistance center in Mexico were suspended due to the COVID-19 pandemic. A total of 71 older adults were evaluated at three different periods: 18 months prior, three months before the pandemic, and 12 months after the onset of the pandemic. Seventy-one older adults completed follow up. Anthropometric measurements, dietary intake, physical tests, and health screening for malnutrition, dependence, and physical frailty, were evaluated. There was a significant decrease in lean body mass and body water in the older adults assessed, in addition to a significant reduction in the frailty scale and gait speed. Finally, a significant reduction in ingested energy and several nutrients such as protein, and carbohydrates, was found, yet an increase in sugar and cholesterol intake was noted.
Bacteria and Bellicosity: Photoperiodic Shifts in Gut Microbiota Drive Seasonal Aggressive Behavior in Male Siberian Hamsters
Authors: Shor Elyan K. , Brown Shawn P. , Freeman David A.
Published: May 2022

The existence of a microbiome-gut-brain axis has been established wherein gut microbiota significantly impacts host behavior and physiology, with increasing evidence suggesting a role for the gut microbiota in maintaining host homeostasis. Communication between the gut microbiota and the host is bidirectional, and shifts in the composition of the gut microbiota are dependent on both internal and external cues (host-derived signals, such as stress and immunity, and endocrine and environmental signals, such as photoperiod). Although there is host-driven seasonal variation in the composition of the microbiota, the mechanisms linking photoperiod, gut microbiota, and host behavior have not been characterized. The results of the present study suggest that seasonal changes in the gut microbiota drive seasonal changes in aggression. Implanting short-day Siberian hamsters ( Phodopus sungorus) with fecal microbiota from long-day hamsters resulted in a reversal of seasonal aggression, whereby short-day hamsters displayed aggression levels typical of long-day hamsters. In addition, there are correlations between aggressive behavior and several bacterial taxa. These results implicate the gut microbiota as part of the photoperiodic mechanism regulating seasonal host behavior and contribute toward a more comprehensive understanding of the relationships between the microbiota, host, and environment.
Nothing but Unworthy Servants? Kierkegaard and Tauler on Grace, Striving and Cooperation
Authors: Becker-Lindenthal Hjördis
Published: May 2022

To counteract the antinomian tendencies of nineteenth-century secular Protestantism, Søren Kierkegaard turns to Johannes Tauler's sermons, which vividly express a dialectics of works and grace, attacking an inflated asceticism as much as idleness. For reasons of reception history and because of the similarity of the images Kierkegaard and Tauler use, particularly servitude as expressed in Luke 17:10, this article proposes to understand Kierkegaard's account of grace as ‘Taulerian’ rather than ‘Arminian’. To show the intertwined agency of the human and the divine, the article offers a comparative reading of Tauler's two sermons on Cantate Sunday, Kierkegaard's Upbuilding Discourse ‘The Expectancy of an Eternal Salvation’ and the second part of Judge for Yourself. Both Kierkegaard and Tauler design definitory ambiguities for a performative purpose: to help their readers and, respectively, listeners to become receptive to grace by humbling themselves and refraining from fathoming ‘what is not given to be understood’.
A hyper-cross-linked polymer derived from pitch as an efficient adsorbent for VOCs
Authors: Liu Huan , Liu Zi-Xin , Yu Hao-Ran , Wang Yan , Zhao Feng-yun , Wang Jian-ying
Published: May 2022

Hyper-cross-linked polymers (HCPs) have been attracted widespread attention as adsorbents in recent years. A series of HCPs (HCP-1, HCP-2 and HCP-3) were synthesized via a Friedel-Crafts reaction using low-cross-linked pitch as precursor and dichloromethane (DCM) as cross-linking reagent and solvent. The prepared HCPs were characterized by N2 adsorption, Fourier transform infrared (FI-IR), Scanning electron microscopy (SEM), Thermogravimetric analysis (TGA) and static water contact angle. The resultant HCPs possess micro/meso pore structures and a high stability. The Brunauer-Emmett-Teller (BET) surface areas of HCP-1, HCP-2 and HCP-3 are 152 m2·g−1, 467 m2·g−1 and 447 m2·g−1, respectively. Their total pore volumes vary from 0.207 cm·g−1 to 0.545 cm3·g−1 and following the sequence of HCP-1<HCP-3<HCP-2. The FTIR spectra of HCPs suggests the DCM is successfully grafted onto the skeleton structure. Dynamic adsorption capacities of the prepared HCP-1, HCP-2 and HCP-3 were examined and the results show the adsorption properties of o-xylene on HCP-2 are significantly higher than that of the other HCPs. The adsorption amount of o-xylene on HCP-2 is 198.18 mg·g−1, which is higher than that of benzene, suggesting a strong adsorption selectivity for o-xylene over benzene. In addition, the effect of water vapor on the adsorption of o-xylene onto HCP-2 was investigated. The dynamic adsorption amount of o-xylene on HCP-2 decreases by 76.47% under the relative humidity (RH) of 30%, implying that the HCP-2 has poor hydrophobicity. The equilibrium adsorption capacity of o-xylene on HCP-2 shows a slight decline after five adsorption cycles.

[Formula: see text]
Numerical and experimental investigation of first ply failure response of multi-walled carbon nanotubes/epoxy/glass fiber hybrid laminated tapered curved composite panels
Authors: Kassa Mesfin Kebede , Singh Lavish Kumar , Arumugam Ananda Babu
Published: May 2022

In this study, first ply failure (FPF) analysis of multi-walled carbon nanotubes (MWCNTs)/epoxy/glass fiber laminated curved composite panels with various taper configuration under transverse uniform pressure load distributed over the panel surface has been performed. In this regard, various failure criterion were considered, including Hoffman, Tsai–Wu, Tsai–Hill, and maximum stress, to investigate the numerical FPF load using finite element (FE) formulation with displacement fields derived from high order shear deformation theory (HSDT) with displacement field having seven degrees of freedom. The effectiveness of the proposed formulation was validated by comparing the numerically predicted FPF load with experimentally obtained FPF load using a universal testing machine from displacement/strain measurement. Finally, the effects of aspect ratio, different weight fraction of MWCNTs, taper configuration, curved geometry, and aspect ratio on the FPF load of the laminated tapered composite panels are studied. The numerical and experimental studies of the first ply failure behavior have demonstrated that the use of MWCNTs ensures a significant improvement in the FPF load of the analyzed laminated tapered curved composite panels. The taper configuration 3 (TC-3) with hyperbolic curved geometry exhibited the highest resistance to failure than taper configuration 1 (TC-1) and taper configuration 2 (TC-2). Moreover, the aforementioned parameters significantly influence the FPF load of laminated curved panels with various taper configurations. Furthermore, this study can be effectively used as a benchmark problem for researchers and as a tool to design practical laminated tapered curved composite panels with sufficient accuracy.
Optimization design for an impeller of the multiphase rotodynamic pump handling gas-liquid two-phase flow
Authors: Zhang Wenwu , Zhu Baoshan , Wang Zhongjing , Wang Fujun
Published: May 2022

The multiphase rotodynamic pump is crucial for the multiphase blending transportation process. However, desigining such pump with high hydraulic performance and good blending transportation ability is quite challenging because of its unique structure. This study constructed a multi-objective optimization design system, which combines the 3D inverse design theory, response surface methodology, genetic algorithm, computational fluid dynamics simulation, and multi-objective optimization strategy, to improve the multiphase pump performance. Five optimization variables, namely the impeller loading parameters ( m1,S, m1,H, kS, kH) and the high-pressure edge angle ( θ), were selected in this study. Furthermore, two optimization objectives were considered at inlet gas void fraction ( IGVF) = 10%, namely the pump efficiency and the gas uniformity at the impeller outlet. The optimization results demonstrated that the pump efficiency and blending transportation ability would improve if the impeller blades had for-loaded loading distribution and the negative high-pressure edge angle. After optimization, the pump efficiency and the gas uniformity for the optimized impeller Opt1 improved by 2.6% and 18.2% at IGVF = 10%, respectively. Moreover, the internal flow pattern in the impeller was improved significantly, resulting in the maximum amplitude of pressure fluctuation in impeller Opt1 being 0.42 times that in the original test impeller.
Development of lacustrine primary productivity in the Amazon Basin during the Holocene
Authors: Soares Juliano HF , Moreira Luciane S , Turcq Bruno , Moreira-Turcq Patricia , Sifeddine Abdel , Dornellas Nayara , Evangelista Heitor , Nogueira Juliana , Aniceto Keila , Martins Gabriel S , Kury Milena S , Brandini Nilva , Contrera Júlia M , Cordeiro Renato C
Published: May 2022

The Amazon Basin is one of the most productive regions in the world and an important carbon sink. However, lake productivity has varied throughout the Holocene, as preserved in lacustrine sedimentary records. Concentrations of chlorophyll pigmented derivatives that are mainly derived from phytoplankton and macrophyte populations can be used to infer lake production levels. Here we use the chlorophyll derivatives concentrations analyzed by spectrophotometer in sediment cores from nine lakes distributed throughout the Brazilian Amazon Basin to document the continental-scale changes in lake production during the Holocene. Chlorophyll derivatives have varied with changes in precipitation rate throughout the last 10,000 years, similar to other climate records in tropical South America, including Ti concentration from the Cariaco Basin, δ13C from Lake Titicaca, and refractory black carbon in Nevado Illimani. Increasing precipitation is responsible for increasing the nutrient supply into the lake, which stimulates primary production. Our analysis was compared to climate-related parameters, suggesting an increasing trend of lake production rates during the wetter Late and Early Holocene, while lower production rates characterized the dry phase of the Middle Holocene. Therefore, the chlorophyll derivatives concentrations generally follow precipitation changes in the Amazon Basin during the Holocene.
MFGE8 decreased neuronal apoptosis and neuroinflammation to ameliorate early brain injury induced by subarachnoid hemorrhage through the inhibition of HMGB1
Authors: Qiu Jiaoxue , Li Wenna , Mu Rutao , Wang Lingling , Guo Lei , Ma Lili
Published: May 2022

Aim

Both MFGE8 and HMGB1 were vital players for aneurysmal subarachnoid hemorrhage. However, whether HMGB1 was served as the downstream target of MFGE8 was unknown. To test this new mechanism, we performed the SAH model in rats.

Method

All treatments were injected intraventricularly into the right lateral ventricles. SAH grade, brain water content, and neurological function scores were evaluated. HMGB1 expression was studied by double immunofluorescence staining. HE and Nissl’s staining were performed to observe the pathological change. Inflammatory factors were measured by ELISA method.

Results

High expression of MFGE8 could improve neurological function and reduce the brain edema and pro-inflammatory factors. Injection of rhMFGE8 inhibited HMGB1. To further verify the regulation of MFGE8 in HMGB1, we used rhHMGB1 and glycyrrhizin, and the results indicated MFGE8 produced excellent effect on SAH rats via inhibiting HMGB1.

Conclusion

In a word, MFGE8 improved EBI caused by SAH, depending on HMGB1 that was the potential mechanism.
Starting from ‘scratch’: Building young people’s digital skills through a coding club collaboration with rural public libraries
Authors: Kelly Wayne , McGrath Brian , Hubbard Danielle
Published: May 2022

While digital infrastructure is clearly a critical factor in addressing the digital divide for rural society, it is only one component in realising the benefits of information and communication technology (ICT). It is increasingly acknowledged that citizens, governments, and businesses need to develop skills and motivations to use technologies. It is also recognised that young people and their rural communities are among those who gain the least from opportunities to engage in and benefit from an ever-evolving digital society. As with other areas of rural development, local community institutions and actors assume their own leadership in developing initiatives to overcome challenges and advance digital literacy and in this regard, public libraries have led and continue to hold considerable potential to champion this area. This article reports on the experiences of a 14-month community-based collaborative research project with public libraries engaged in a process of developing coding clubs for children and youth in rural Manitoba, Canada. Our research sets out to answer the questions: first, whether it is viable for public libraries to cultivate advanced digital skills among rural youth and contribute to bridging the rural-urban digital divide by running coding clubs following the CoderDojo model? And second, what are the critical conditions to ensure the success of public library coding clubs? In examining some of the experiences encountered in adopting the coding club as a model of digital literacy building, we discuss wider themes for rural public libraries interested in advancing digital literacy building within their communities.
Models of Identity Signaling
Authors: Smaldino Paul E.
Published: May 2022

Identity signals inform receivers of a signaler’s membership in a subset of individuals, and in doing so shape cooperation, conflict, and social learning. Understanding the use and consequences of identity signaling is therefore critical for a complete science of collective human behavior. As is true for all complex social systems, this understanding is aided by the use of formal mathematical and computational models. Here I review some formal models of identity signaling. I divide these models into two categories. First, I discuss models used to study how identity functions as a signal, with a focus on public-health-related behavior and disease transmission. Second, I discuss models used to understand how identity signals operate strategically in different social environments, with a focus on covert, or encrypted, communication.
An Analysis of Utilization of Maternal Health Services with Respect to Information Received and Impact of Demographics in Punjab, India
Authors: Sharma Vijayetta , Kamra Pawan K.
Published: May 2022

The value information leads to effective utilisation of services. The study identifies the gap in information about maternal health services and their utilisation. The information which has led to utilisation of services can be assiduously labelled as value information or value awareness. The relationship has been explored between awareness about maternal health services and service utilisation among Janani Suraksha Yojana (JSY) beneficiaries in Punjab, a high-performing state in India as per NRHM. Further, an assessment of impact of demographics on beneficiaries with information and those who utilised the services has been explored. Information received and utilisation of ante-natal checkups (ANC), delivery care and post-natal checkups (PNC) services have been studied for two districts in the state of Punjab, India. Chi-square test has been applied to know the association between the maternal health services and the select districts with respect to information and services utilised. Impact of demographic variables such as age, education, income and caste have been evaluated for information and utilisation of maternal health services. The dispersed information that has not triggered in utilisation of services by JSY beneficiaries have been used as an ingredient to explore and understand the deterring factors in non-utilisation of maternal care services in the rural areas of developing country like India. Results highlight that a significant association exists between the utilisation of maternal health services among the select districts in the state of Punjab ( χ2 = 8.73, p-value = 0.0127); however, there is no association between the informed beneficiaries and the districts for the maternal health services. No impact of demographic variables has been found on the beneficiaries with information about maternal health services and those who utilised the services. The gap in awareness and utilisation of services throws light on the lurking concerns of unrecognised benefits, uncaring attitude towards health, prejudices about institutional delivery and PNC being considered an unimportant service among the beneficiaries.
A Guide to Incorporate Augmentative and Alternative Communication Into Functional Communication Training
Authors: Ousley Ciara L. , Raulston Tracy J.
Published: May 2022

Children with autism spectrum disorder often display some form of challenging behavior and have complex communication needs. Functional communication training is an evidence-based practice that (a) decreases challenging behavior and (b) increases appropriate communicative behavior. Recent research has demonstrated how using augmentative and alternative communication (i.e., various forms of communication that do not involve vocal speech) can be successfully incorporated into functional communication training interventions. This article introduces a four-step guide on how to incorporate augmentative and alternative communication within functional communication training interventions. Detailed guidelines on how to incorporate augmentative and alternative communication, along with a vignette example, are provided.
Criminal Action Against Drug Counterfeiters: Assessment of the FDA Office of Criminal Investigation Database 2016 Through 2021
Authors: White C. Michael
Published: May 2022

Objective

The objective of this study was to describe law enforcement oversight of counterfeit drugs by the Food and Drug Administration (FDA) in the United States from 2016 through 2021.

Methods

The FDA Office of Criminal Investigation database with hyperlinked press releases of enforcement actions was used to identify legal action against drug counterfeiters. Incidences of counterfeit drugs sold via Internet, how often they were obtained without a prescription, the most prevalent counterfeit drugs, the countries where counterfeit operations occurred, and the scale of counterfeit operations were assessed.

Results

There were 130 unique enforcement actions against counterfeiting organizations and individuals. Overall, 64.6% of enforcement actions involved counterfeit products sold over the Internet, in 84.6% of actions counterfeit medications could be obtained without a prescription, and in 33.1% of actions the products were sold as dietary supplements. Sexual dysfunction, opioid, stimulant, anabolic muscle building, benzodiazepine, and dermatologic drugs were most counterfeited. China was the most prevalent country to produce counterfeit drugs followed by India, Turkey, Pakistan, and Russia. Counterfeiting operations were large with tens of millions of pills and hundreds of millions of dollars in sales. Health outcomes for counterfeit drugs were rarely discussed in the press releases and not all press releases had data for each parameter of interest.

Conclusion and Relevance

This is the first report assessing enforcement actions against drug counterfeiters from the FDA Office of Criminal Investigation. The FDA is actively involved in identifying and prosecuting counterfeit drug rings, but the number of enforcement actions is smaller than the size of the problem.
Rhabdomyosarcoma With Epithelioid Features And NSD3::FOXO1 Fusion: Evidence For Reconsideration Of Previously Reported FOXO1::FGFR1 Fusion
Authors: Rakheja Dinesh , Park Jason Y. , Yang Mary S. , Martinez Diana P. , Koduru Prasad , Wilson Kathleen S. , Garcia Rolando , Uddin Naseem
Published: May 2022

Epithelioid rhabdomyosarcoma is a rare rhabdomyosarcoma variant for which no diagnostic recurrent driver genetic events have been identified. Here we report a rapidly progressive and widely metastatic rhabdomyosarcoma with epithelioid features that arose in the thigh of a male infant. Conventional cytogenetics revealed a t(8;13)(p11.2;q14) translocation. Fluorescence in situ hybridization studies showed rearrangement of FOXO1 and amplification of its 3” end, and rearrangement of NSD3 and amplification of its 5` end. Next generation sequencing identified a NSD3::FOXO1 fusion, which is a previously unreported gene fusion. We also review the historic report of a FOXO1::FGFR1 fusion in a solid variant of alveolar rhabdomyosarcoma and propose that NSD3::FOXO1 fusion may have been the more appropriate interpretation of the data presented in that report.
Giant Cell Tumor of Bone Without Giant Cells with a Long Clinical Course: A Case Report
Authors: Takase Hiroki , Kato Ikuma , Ito Junko , Kawabata Yusuke , Okabe Tetsuhiko , Takeyama Masanobu , Fujii Satoshi
Published: May 2022

Giant cell tumor of bone (GCTB) consists of a mixture of neoplastic mononuclear cells and non-neoplastic cells, including polynuclear giant cells. Recently, with the spread of the immunohistochemical staining marker H3.3 G34W corresponding to specific genetic abnormalities, the histological diversity of GCTB has been recognized. GCTB without giant cells is uncommon, although it has also been reported previously. Herein, we describe a 45-year-old man with GCTB without giant cells who was successfully diagnosed using H3.3 G34W immunohistochemistry. Other unusual findings in GCTB that were identified in this patient include bone and osteoid formation with a long clinical course of 13 years. We also compared the histological findings of the current patient to those who received denosumab therapy.
The foundation of island identity: Chamorro maritime practices and resistance in the Commonwealth of the Northern Mariana Islands
Authors: Mushynsky Julie , McKinnon Jennifer , Cabrera Genevieve , Tudela Herman
Published: May 2022

Scholars have used terminal narratives when discussing Chamorro culture in the Commonwealth of the Northern Mariana Islands, especially in relation to its maritime connections. Researchers and administrators have done this explicitly by claiming that Chamorro people have lost touch with the sea because of long periods of colonization and implicitly through the routine omission of Chamorro people in studies of Micronesian cultures. Through a historical and archeological study that collaborates with contemporary Indigenous peoples, we argue that Chamorro maritime cultural identity, while it changed in response to the social environment, has persisted into the present. Maritime activities, particularly fishing and canoeing, have been a part of the daily lives of Chamorro people from 4,000 BP to the present, despite restrictions placed on these activities by four colonial powers. Furthermore, we find that asserting maritime connections have become a form of resistance in response to the current political climate.
Luckily—I am not the worrying kind: Experiences of patients in the Danish cancer patient pathway for non-specific symptoms and signs of cancer
Authors: Damhus Christina Sadolin , Brodersen John Brandt , Risør Mette Bech
Published: May 2022

In Denmark, due to the implementation of the Non-specific Symptoms and Signs of Cancer-Cancer Patient Pathway (NSSC-CPP), more people with symptoms such as fatigue and weight loss are informed that their symptoms might indicate cancer and they are referred to the pathway. But what do patients in the NSSC-CPP experience, in particular, with respect to being in an affective state of anticipation of a cancer diagnosis? We conducted participant observation and semi-structured interviews with patients to investigate their experience of the NSSC-CPP with a specific focus on their perception of symptoms and their thoughts on worrying about cancer. We found that the phrase ‘worried about cancer’ was not recognised by the participants, but worry was visible in their increased healthcare use and their interpretation of bodily sensations. Our study indicates the need to explore the impact of anticipation and potential cancer worries in participants’ everyday lives, as this context mediates their moral roles and responsibilities and restructures their social lives, while keeping uncertainty and probabilities on the table.
How social media users perceive different forms of online hate speech: A qualitative multi-method study
Authors: Schmid Ursula Kristin , Kümpel Anna Sophie , Rieger Diana
Published: May 2022

Although many social media users have reported encountering hate speech, differences in the perception between different users remain unclear. Using a qualitative multi-method approach, we investigated how personal characteristics, the presentation form, and content-related characteristics influence social media users’ perceptions of hate speech, which we differentiated as first-level (i.e. recognizing hate speech) and second-level perceptions (i.e. attitude toward it). To that end, we first observed 23 German-speaking social media users as they scrolled through a fictitious social media feed featuring hate speech. Next, we conducted remote self-confrontation interviews to discuss the content and semi-structured interviews involving interactive tasks. Although it became apparent that perceptions are highly individual, some overarching tendencies emerged. The results suggest that the perception of and indignation toward hate speech decreases as social media use increases. Moreover, direct and prosecutable hate speech is perceived as being particularly negative, especially in visual presentation form.
Socio-cultural sustainability and small tourism businesses
Authors: Roberts Sherma
Published: May 2022

Early assumptions pertaining to the sustainability of small tourism businesses (STBs) have been answered specifically as it relates to environmental sustainability. What is less well documented and still unclear is the extent to which STBs enhance the socio-cultural sustainability of the destination. This lacuna is surprising, given the development of indicators of sustainable tourism. This study therefore fills this gap by utilizing sustainability indicators to examine the extent to which small tourism businesses, across a number of sectors, contribute to destination sustainability. Using a conceptual approach premised upon principles of socio-cultural sustainability to construct the reference condition for indicator development, the study found that businesses performed better on indicators related to equity and cultural conservation but had mixed performance in the area of social cohesion, and were borderline on empowerment. The theoretical contribution of the study is that it provides operational validity to the assumptions governing small tourism businesses and socio-cultural sustainability by employing indicators developed through the scientific consensus approach. Using this approach, the study is able to measure socio-cultural sustainability contributions across myriad sectors.
One village, many nostalgias: The entanglements of embodied scopic regimes in the landscape production of Chinese nostalgia tourism
Authors: Yuan Yan
Published: May 2022

This article uses investigations into two villages to scrutinise the politics of space and visuality in the top-down development of nostalgia tourism across the Chinese countryside engineered by the government since 2014. It goes beyond the debate between the representational and non-representational approaches in tourist landscape studies and proposes the concept of ‘embodied scopic regimes’ as a more nuanced framework of analysis. It is argued that the landscape production in the current development of nostalgia tourism in China is featured by the coexistence and entanglement of three different embodied scopic regimes: ‘stop/gaze regime’, ‘flâneur/glance regime’ and ‘choraster/spectacle regime’. Each regime produces a unique fashion of visual pleasure and distinct mode of physical movements, manifested and afforded by different sets of cultural technologies. The operation of these multiple regimes also diversifies the meanings of nostalgia that these tourist sites claim to represent, which allows the overlapping between ‘reflective nostalgia’ and ‘restorative nostalgia’ in the same space. Based on this unique case, the article engages with the ‘landscape debate’ in critical tourist studies and extends the common ground between the two seemingly oppositional approaches.
Bilateral Implantation of Double-Branched Iliac Branch Devices for Endovascular Repair of Aorto-Bi-Iliac Aneurysm With Concomitant Hypogastric Aneurysms: The Quadruple Branch
Authors: Friesen Lia , Asciutto Giuseppe , Schaefers Johannes Frederik , Oberhuber Alexander
Published: May 2022

Purpose:

The purpose of this report is to describe the use of a double-branched custom-made iliac branch device (IBD) for the endovascular repair of an aorto-bi-iliac aneurysm with concomitant bilateral hypogastric aneurysms.

Technique:

A 61-year-old man on peritoneal dialysis underwent a computed tomography (CT) of the infrarenal aorta before planned kidney transplantation. The CT showed an asymptomatic aorto-bi-iliac aneurysm of 54 mm involving the hypogastric artery (HA) bilaterally (right HA 31 mm; left HA 40 mm). The treatment consisted of an endovascular aortic repair (EVAR) and the bilateral implantation of custom-manufactured IBDs with double inner branches to preserve both superior and inferior gluteal arteries. At 1 year follow-up, the patient remains free of symptoms and the postoperative CT showed a successfully excluded aneurysm with patent bridging stent grafts to all HA branches.

Conclusion:

The bilateral implantation of double-branched IBDs is a feasible technique. Preservation of both hypogastric arteries and its branches can be achieved with this technique and therefore decrease the risk of buttock claudication and other ischemic complications.