bluuebunny/crossref_metadata_2025 huggingface dataset:
Cucurbituril-based Supramolecular complexes with platinum compounds influence on expression of CTLA-4 on Regulatory T cells
Authors: Aktanova A. A. , Bykova M. V. , Boeva O. S. , Pashkina E. A. , Grishina L. V. , Kozlov V. A.
Published: June 2023

Tumors are a leading pathology in the population. Chemotherapy cannot provide adequately and effectively to cure patients. Some medicine, such as cytostatic, are characterized by a wide range of side effects and resistance of solid tumors to chemotherapy by these medicines. In recent research, the mechanisms of action of cytotoxic agents have been described, and the most appropriate causes of resistance have been suggested. Drug delivery system based on Cucurbit[7]uril (CB[7]) was used to minimize side effects and overcome resistance. CB[7] has ability to form host-guest supramolecular complexes with oxaliplatin and carboplatin.

It is important to consider the immune system maintain to a great role, and platinum compounds are able to have an immunomodulatory effect on immunocompetent cells. There is convincing evidence about the cytotoxic response against tumor cells is also associated with immunomodulating properties. A specific immune microenvironment with high frequency of suppressor cells is made by tumors. FoxP3+ regulatory T cells are recruited by the tumor, an increased number of these cells and expression levels of CTLA-4 and PD-1 on them contribute to the progression of the tumor process. These markers correlate with recurrence and poor survival of the patients. Therefore, it is necessary that antitumor therapy agents have an effect on a subpopulation of regulatory T cells and their functional activity. This study evaluated the effects of cucurbit[7] uril, platinum compounds, and supramolecular complexes on FoxP3+ regulatory T cells and the expression of immune checkpoint molecules.

In this study peripheral blood cells from volunteers (n = 8, average 29.0±2.4) were used. Mononuclear cells obtained in the standard protocol were incubated for 72 h at concentrations of 0.3 and 0.1 mM for carboplatin and oxaliplatin, respectively, as well as complexes and CB[7] in equivalent dosages. Next, the samples were labeled with monoclonal antibodies to determine the phenotype and expression of immune checkpoint molecules by flow cytometry.

We obtained the following results: The CB[7]-carboplatin complex in stimulated and non-stimulated cultures significantly reduced the number of FoxP3+ regulatory T cells compared to the control. At the same time, carboplatin and the CB[7]-carboplatin complex reduced the expression of CTLA-4 in an non-stimulated culture compared to CB[7].

Complexes of Cucurbit[7]urils with platinum compounds are a perspective antitumor agent with immunomodulatory properties.
Complexity of immunobiology of tumor necrosis factor and novel anti-TNF therapy
Authors: Nedospasov S. А.
Published: June 2023

Tumor Necrosis Factor (TNF) was discovered almost 50 years ago as “serum factor” detected in mice following infections or administration of bacterial lipopolysaccharide (LPS), with a remarkable anti-tumor effect. Molecular cloning showed that this activity is mediated by a small protein (17 kDa), which belongs to a wide plethora of cytokines. Due to the particular organization of the TNF gene coding sequence, all cells producing soluble TNF also carry a membrane-bound cytokine on their surface. The physiological effects of TNF are mediated by signaling through two types of highly specific receptors. Despite established protective and homeostatic functions of TNF, when overproduced systemically or locally, it can trigger pathologies ranging from septic shock to autoimmune diseases. Therefore, in clinical immunotherapy there were not the TNF agonists, which were expected to induce anti-tumor effects, but rather the antagonistic blockers, that proved effective in a wide range of autoimmune diseases with an inflammatory component. Our studies in mice based on the technologies of reverse genetics and experimental disease models, revealed a paradoxical feature of TNF: some cellular sources of this cytokine (such as myeloid cells) promoted diseases, while other cell types (such as T lymphocytes) produced a protective form of the same cytokine. There are several possible mechanistic explanations for this phenomenon. On the one hand, the "pathogenic" cytokine is produced in a soluble form and can exert systemic effects via broadly expressed TNFR1. On the other hand, protective functions are mediated by the membrane-bound TNF via TNFR2. Systemic anti-cytokine therapy is known to be accompanied by undesirable side effects, which can hypothetically be explained by the neutralization of these protective functions. Thus, we developed prototypes of TNF blockers which limit the bioavailability of this cytokine only from its main “pathogenic” source – myeloid cells. This type of inhibitors, called MYSTI, represent bispecific mini-antibodies binding both TNF and a surface marker on myeloid cells and lacking the Fc domain. MYSTI retain newly synthesized TNF on the surface of the producing cell and then internalize it. This novel type of immunotherapy drug has already shown efficacy in a number of experimental disease models.
O Sistema de Mundo de Newton e as geometrias não-euclidianas no século XIX: relações possíveis?
Authors: Silva Ana Paula Bispo da , Gomes Maria Gabriela Ferreira Siqueira Amaral
Published: June 2023

No presente trabalho tivemos como objetivo investigar como a teoria de gravitação de Isaac Newton, presente no Livro III dos Principia – Sistema de Mundo – foi abordada durante o século XIX, quando as geometrias não-euclidianas estavam sendo empregadas no estudo da mecânica em superfícies com curvatura diferente de zero. Para isso, realizamos um estudo dos principais aspectos do Livro III e da geometria utilizada por Newton; apresentamos os princípios da geometria não-euclidiana em discussão no século XIX e realizamos uma busca bibliográfica na Royal Society em busca de trabalhos que relacionassem esses dois temas. Como resultado, encontramos apenas um trabalho durante o século XIX em que alguns conceitos newtonianos de movimento são discutidos sob as ideias riemannianas de métrica, em que a curvatura do espaço adotado não influencia as equações de movimento. Concluímos assim que não houve uma diferenciação, em termos dos movimentos dos corpos celestes, no espaço absoluto de Newton mesmo quando a geometria não euclidiana trazia novas interpretações e possibilidades.
Avaliação do comportamento das fibras colágenas periodontais durante a progressão da periodontite experimental em ratos
Authors: GARCIA Matheus Esnel , FARIA Felipe de Lima , DAL OCA COSTA SILVA Bianca , ERVOLINO Edilson , NOVAES Vivian Cristina Noronha , TORO Luan Felipe
Published: June 2023

Resumo Introdução A periodontite é uma doença infecto-inflamatória, resultante da disbiose microbiana e da resposta do hospedeiro, que leva à destruição dos tecidos de suporte dentário, inclusive das fibras colágenas periodontais, podendo culminar na perda do elemento dental. Objetivo Avaliar o comportamento das fibras colágenas periodontais durante a progressão da periodontite experimental induzida em ratos. Material e método Doze ratos Wistar foram distribuídos nos grupos: Controle (C), Periodontite Experimental 14-dias (PE-14d), Periodontite Experimental 21-dias (PE-21d) e Periodontite Experimental 42-dias (PE-42d). No dia 0, os animais do grupo C foram eutanasiados. Neste mesmo dia, os animais remanescentes foram submetidos à instalação de uma ligadura de algodão ao redor do primeiro molar inferior esquerdo para indução da periodontite experimental. Tais animais foram eutanasiados aos 14 (PE-14d), 21 (PE-21d) e 42 (PE-42d) dias após a instalação da ligadura. Executou-se o processamento histológico das hemimandíbulas e as secções foram submetidas à reação histoquímica pelo vermelho picro-sirius. A análise qualitativa descritiva foi realizada sob microscopia de luz polarizada, na região de furca dental, evidenciando as fibras do ligamento periodontal. Resultado O grupo C exibiu feixes espessos e orientados de fibras colágenas maduras, condizentes com aspecto de normalidade. Os grupos com periodontite experimental exibiram desestruturação tecidual severa, com fibras colágenas imaturas e de menor espessura, sendo tais condições mais exacerbadas nos grupos PE-14d e PE-21d. Conclusão As fases iniciais da periodontite apresentam caráter agudo e, portanto, resultam na rápida destruição dos tecidos periodontais de suporte, prejudicando potencialmente a fibrilogênese e a reestruturação do colágeno no ligamento periodontal.
Child vaccination in animated infographic: technology for permanent education about the nursing process
Authors: Ferreira Fernanda Medrado de Souza , Silva Francislene do Carmo , Natarelli Taison Regis Penariol , Mello Débora Falleiros de , Fonseca Luciana Mara Monti
Published: June 2023

ABSTRACT Objective: To develop and validate an animated infographic about the nursing process in childhood vaccination. Method: Methodological study for the development and validation of educational technology, an animated infographic, on childhood vaccination. First, contents from the Ministry of Health that should compose the infographic were selected. Then, a script was prepared and a storyboard used to guide the production of the animated infographic. Once finalized, the technology went through the content and appearance validation process with nursing experts in the study area. Results: Sixty-nine screens of storyboard were done and the infographic lasted five minutes and 52 seconds. Forty-five nurses were selected and, of these, 21 agreed to participate in the study. The infographic was evaluated according to its objectives, structure, presentation, and relevance, resulting in an overall CVI of 97%. Conclusion: The animated infographic produced was validated by experts and, once adapted following the judges’ suggestions, it became a valid educational tool to be used by students and nursing professionals.
PERCEPTION OF NURSES ABOUT NURSING TELECONSULTATION IN PRIMARY CARE
Authors: Zluhlan Larissa Schmitt , Amadigi Felipa Rafaela , Machado Rosani Ramos , Lino Monica Motta , Pires Denise Elvira Pires de , Costa Sandra Regina da , Castro Luiza Sheyla Evenni Porfirio Will
Published: June 2023

ABSTRACT Objective analyze the nurse’s perception about nursing teleconsultation in Primary Health Care through the workflows characterization, potential, challenges and teleconsultation in nursing feasibility. Method exploratory-descriptive study with a qualitative approach. Data were collected, between the months of May and June 2021, with 19 nurses from four health districts of a capital in south of Brazil, using digital questionnaire. Data were systematized in Microsoft ExcelⓇ and analyzed following the criteria of the Discourse of the Collective Subject. This process was carried out with the support of the DSCsoftⓇ Program. Results the results were organized into five thematic categories: Nursing teleconsultation flow in Primary Health Care; Teleconsultation process; Instruments used during the teleconsultation; Potentialities and challenges identified during the teleconsultation in the Primary Health Care; and, Applicability: services that can be resolved through teleconsultation. Among the challenges are the inherent problems of communication and internet connectivity and the distrust of users in relation to this new consultation modality. Conclusion telecare in nursing is a recent technological innovation, with several challenges as: the possible failure in communication between the professional and the user; internet connection problems; lack of ability to travel from new tools; lack of privacy and excessive noise and distrust of users about the service provided. With the teleconsultation, there was an extension of the users' access to the health services, there was greater agility and efficiency in the services provided to the population.
FACULTY ATTITUDES TOWARD TEACHING STUDENTS WITH MILD INTELLECTUAL DISABILITIES IN HIGHER EDUCATION
Authors: ALMUTAIRI Hamaed
Published: June 2023

ABSTRACT The purpose of this study was to examine the relations between faculty members’ attitudes in Higher Education Saudi universities and demographic factors (i.e., academic rank, gender, years of experience, and type of college) by using the Interaction with Disabled Persons (IDP) Scale and multiple regression analysis. Results indicate that gender was associated with one dimension: vulnerability. The ranks of assistant professor and full professor were related to two dimensions: discomfort in social interactions and a coping-succumbing framework. Also, the college education variable was related to three dimensions: discomfort in social interactions, perceived level of information, and vulnerability. Results show that faculty members had lower negative attitudes toward students with mild intellectual disabilities in Higher Education. Based on study results, the researcher recommends more faculty training in how to support the Higher Education of students with disabilities as well as accessible support centers for individuals with disabilities to help staff as well as students. Also, universities should be made accessible to people with all types of disabilities who have a right to Higher Education.
ENTREVISTA COM A PROFESSORA MARIA AMÉLIA ALMEIDA: CAMINHOS PA RA A EDUCAÇÃO ESPECIAL E A DEFICIÊNCIA INTELECTUAL NO BRASIL1
Authors: ALMEIDA Maria Amélia , LOURENÇO Gerusa Ferreira , SILVA Aline Maira da
Published: June 2023

RESUMO A consolidação da produção de conhecimento em Educação Especial no Brasil é marcada pela trajetória de professores pioneiros que puderam vivenciar formações internacionais e trazer para o país inovações da atuação junto aos estudantes com deficiência, além da expertise em delineamentos de pesquisa para essa produção. Assim sendo, este texto traz uma entrevista com a Professora Maria Amélia Almeida, da Universidade Federal de São Carlos, com a narrativa das oportunidades de formação em pesquisa vivenciadas e o seu interesse na área da Deficiência Intelectual. A Professora Maria Amélia Almeida destaca o processo de tradução e de validação, para o Brasil, da Escala de Intensidade de Suporte sob o qual ela tem se debruçado em seu grupo de pesquisa ao longo dos últimos anos e reconhece o importante papel da Revista Brasileira de Educação Especial para a área no Brasil.
REVISTA BRASILEIRA DE EDUCAÇÃO ESPECIAL: 30 ANOS DE HISTÓRIA
Authors: FIORINI Maria Luiza Salzani , ROLIM Carmem Lucia Artioli , LOCKMANN Kamila
Published: June 2023

RESUMO Neste artigo, objetivou-se revisitar a história da Revista Brasileira de Educação Especial (RBEE), com um olhar voltado às construções expressas na organização e na estruturação da revista, no decorrer de três décadas de existência. Para isso, percorreram-se as publicações da RBEE de 1992 a 2021, de modo a coletar, organizar e analisar dados sistematizados por meio de unidades de análise. Metodologicamente, o trabalho foi organizado em dois momentos: inicialmente, foram objetos de estudo os sumários, os títulos, os editoriais, as erratas, os informes, as avaliações e os prêmios da revista; em um segundo momento, os títulos das pesquisas publicadas receberam atenção e suas expressões foram sistematizadas para a criação de nuvens de palavras. Desses movimentos, desprendeu-se a criação de três unidades de análise, as quais foram organizadas respeitando marcos históricos evidenciados na RBEE: I) Fase da Criação, a qual contemplou o período de 1992 até 2004, marcado pelo início da institucionalização da RBEE; II) Fase da Expansão, que envolveu o período de 2005 até 2012, no qual se visualizou a manutenção da periodicidade, assim como a indexação da RBEE no sistema Scientific Electronic Library Online (SciELO); III) Fase de Consolidação, a qual compreendeu o período de 2013 até 2021, caracterizado, sobretudo, pela internacionalização da Revista e pelo alcance do Qualis Capes A1 em Educação.
ENTREVISTA COM A PROFESSORA MÔNICA DE CARVALHO MAGALHÃES KASSAR: POLÍTICAS DE EDUCAÇÃO ESPECIAL NO BRASIL
Authors: KASSAR Mônica de Carvalho Magalhães , LOCKMANN Kamila , REBELO Andressa Santos
Published: June 2023

RESUMO O presente texto traz uma entrevista realizada com a Professora Mônica de Carvalho Magalhães Kassar, da Universidade Federal de Mato Grosso do Sul, acerca das movimentações e dos deslocamentos históricos produzidos nas políticas de Educação Especial no Brasil, especialmente no que se refere às problematizações acerca do Decreto nº 10.502/2020. Ao longo da entrevista, a pesquisadora destaca alguns marcos históricos importantes no campo da Educação Especial, refere os retrocessos e os perigos que se vislumbram com o Decreto n° 10.502/2020 e ainda discute o problema do financiamento público à educação.
THE ALTERNATION OF VERBS WITH MOTIVATING ARGUMENT IN BP: A TYPE OF FACTORING OF ARGUMENT
Authors: MEIRELLES Letícia Lucinda
Published: June 2023

ABSTRACT In this paper, we analyze a type of alternation that allows to express the complex constituent, which is originally in the object position, in two different syntactic positions, such as in the sentences: os alunos admiram o brilhantismo do professor [students admire the teacher’s brilliance]/os alunos admiram o professor pelo brilhantismo [students admire the teacher for his brilliance]. For the analysis of this phenomenon, we used the proposal of thematic papers as a cluster of discrete semantic properties of Cançado (2005) and Cançado and Amaral (2016)). We propose that the analyzed alternation results from the factoring of the complex verb argument, being determined by semantic restrictions of nominal and verbal level. At the first level, the complex arguments which can be factored must denote a possession relationship, as in the phrase o brilhantismo do professor [the brilliance of the teacher] or the relationship between an eventive name and its agent, such as the nominal phrase a excelente atuação do artista [the excellent performance of the artist] in the alternation o público aplaudiu a excelente atuação do artista [the audience applauded the excellent performance of the artist]/o público aplaudiu o artista por sua excelente atuação [the audience applauded the artist for his excellent performance]. At the verbal level, the verbs that perform this alternation can be grouped into a coarse-grained class (LEVIN, 2010), as they all attribute the semantic properties estativo [estative], objeto de referência [reference object] and objeto motivador [motivating object] to their complex argument, which can be factored. Finally, we propose that the alternation is motivated by pragmatic factors related to the informational structure of the analyzed statements.
Percepção de Danos Físicos, Psíquicos e Sociais no Trabalho de Ser Mãe Universitária
Authors: Antloga Carla Sabrina , Monteiro Renata Alves , Bentes Alice Miranda , Cassimiro Êmili Campos , Assunção Fernanda da Silva
Published: June 2023

Resumo A vida universitária de mulheres mães apresenta questões que precisam ser mediadas quando comparadas com a mesma dinâmica em estudantes que não são mães. O referencial teórico da psicodinâmica do trabalho reconhece o estudar e o maternar como trabalho, pois demandam esforço cognitivo, físico e temporal com finalidade social. O objetivo deste artigo foi avaliar os danos advindos desses dois trabalhos, sobretudo, em suas dimensões física, psicológica e social, na vida de mães universitárias com filhos de até cinco anos de idade. Utilizou-se a metodologia quantitativa com ajuda da aplicação da Escala de Avaliação dos Danos Relacionados ao Trabalho (EADRT), e adaptada para o contexto estudantil e materno. A pesquisa foi respondida por 453 mães universitárias. Dessa forma, foi encontrada uma amostra heterogênea, cujas respostas apontaram para diferenças na percepção dos danos; correlações dos fatores; e associações com as variáveis sociodemográficas. Logo, discute-se a presença de danos físicos, sociais e psicológicos considerados graves para as duas atividades. No entanto, quando as mães universitárias residem com um companheiro ou têm maior renda, os danos sociais e psicológicos se mostraram menores. Com efeito, esta pesquisa ampliou o conhecimento sobre quem são as mães brasileiras na graduação e que tipo/grau de danos à saúde elas vivenciam, destacando que o acúmulo dos dois papéis acarreta níveis críticos que podem ser atenuados pelo apoio familiar e pela assistência às questões de vulnerabilidade econômica. Por fim, reforça-se a preocupação em analisar cientificamente essas realidades, servindo de embasamento para políticas públicas e estratégias futuras de intervenção.
Marvell’s Issues: Race and the Curse of Ham
Authors: Lerner Ross
Published: June 2023

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Os espaços públicos e a acessibilidade para permanência das pessoas na Ponte Hercílio Luz- Florianópolis/SC
Authors: Luberisse Clerdine , Pfutzenreuter Andrea Holz
Published: June 2023

Os espaços públicos interferem e contribuem na qualidade da vida coletiva do contexto social e urbano, quando possibilitam o seu uso e apropriação de forma igualitária. Este artigo tem como objetivo analisar a relação entre a permanência e a acessibilidade emocional no espaço público da ponte Hercílio Luz, de Florianópolis, considerado como um marco histórico, capaz de promover espaços de convívio e de trocas sensoriais. Para esse estudo, foi feita uma revisão bibliográfica dos últimos 10 anos de publicações nos periódicos: Scielo e Capes, sobre o tema e os conceitos relacionados. Em seguida outras bibliografias estudadas anteriormente foram relidas e alguns sites e jornais foram consultados para compreender a história do objeto de estudo, sua importância como espaço público na vida da comunidade. Para a análise também foram realizados levantamentos fotográficos em dias em que a ponte apresenta formas de uso bem distintas. Concluímos que a ponte é um espaço acessível, porém é difícil afirmar que é um espaço inclusivo. Os resultados do estudo reforçam a importância de espaços públicos acessíveis e representativos. Assim, a importância desse estudo se destaca por evidenciar fatores que influenciam a acessibilidade emocional e permanência dos usuários nos espaços públicos. Também tem sua relevância por iniciar uma discussão sobre a necessidade de incentivar desenho inclusivo capaz de oferecer uma apropriação efetiva a todos.

PALAVRAS-CHAVE: Espaço público. Desenho inclusivo. Acessibilidade emocional.
On image agency
Authors:   Taras Shevchenko national University of Kyiv, Levchenko Illia
Published: June 2023

Horst Bredekamp is an art historian and representative of the science of images (Bildwissenschaft), known for his research on the image agency. In the two reviewed works, the image appears as an independent agent that operates in the political space and essentially creates this political space. In the study "Image Act. A Systematic Approach to Visual Agency" (2018), Bredekamp attempts to systematize the methods of image action. The types of acts singled out by the researcher exist outside of linear chronology and are ways of manifesting an image. The image can combine several different types of acts. First, Bredekamp considers the image as a determinant of man as a species, a manifestation of the cognitive revolution, man's ability to act of differentiation, and his ability to transform nature. Despite this, the researcher goes to the meaning of Charles Darwin's teaching "The Expression of the Emotions in Man and Animals" (1872) to develop the concept of "pathosformel" (pathosformel) of Aby Warburg. After all, Brellekamp concludes images of nature continue human images, not oppose them. The second of the analyzed works, "Leviathan: Body politic as visual strategy in the work of Thomas Hobbes" (2020), is built around the analysis of the frontispiece to Hobbes's treatise "Leviathan or The Matter, Forme and Power of a Common Wealth Ecclesiasticall and Civil" (1651). Bredekamp constructs research by involving an impressive source complex, thus demonstrating that a work of art is both an actor involved in society. Combining the analysis of these two works in one text makes it possible to see how Bredekamp's theory can be applied to the specific source material.
The History of Territorial Psychiatric Hospitals in Russia
Authors: Tselischev Dmitry V. , Chernyaev Mikhail I.
Published: June 2023

The establishment of district psychiatric hospitals in the Russian Empire in the second half of the 19th-early 20th century is one of the most important stages in the development of domestic psychiatry. In fact, it was the first experience in the design and construction of psychiatric hospitals as large specialized autonomous complexes aimed not only at isolation of patients, but also at therapy of their condition. The idea of building such institutions was suggested by reality itself: city houses for the mentally ill under the jurisdiction of provincial and then zemstvo authorities were overcrowded, but there was a lack of specialized doctors, since psychiatry in Russia in the first half of the 19th century was only beginning to gain scientific prestige. In a sense, the development of Russian psychiatry and the evolution of the project of district hospitals for the mentally ill pushed each other: leading psychiatrists of their time took a most enthusiastic part in the development of the project, and the hospitals established through their efforts provided enormous practical material for studying mental diseases and methods of their therapy.
ANALYSIS OF THE USE AND USEFULNESS OF PUBLIC SECTOR ENTITIES' REPORTS IN THE REPUBLIC OF CROATIA
Authors:   Sveučilište u Zagrebu, Ekonomski fakultet Zagreb, Pajković Ivana
Published: June 2023

Svrha je financijskih izvještaja proračuna i proračunskih korisnika pružiti pravovremene informacije o financijskom položaju i financijskoj uspješnosti te novčanim tijekovima. Stoga su financijski izvještaji ključni prilikom poboljšanja odgovornosti i donošenja odluka javnih menadžera. Budući da kvaliteta informacija prezentiranih u financijskim izvještajima ovisi o računovodstvenoj osnovi, a financijski izvještaji pripremljeni na obračunskoj osnovi pružaju najkvalitetnije i najpotpunije informacije, cilj je ovoga rada utvrditi jesu li financijski izvještaji pripremljeni na modificiranoj obračunskoj osnovi korisni u procesu donošenja odluka iz dviju perspektiva: perspektive javnih menadžera te perspektive računovođa u javnom sektoru Republike Hrvatske, koji sudjeluju u procesu pripreme propisanih financijskih izvještaja. Pored financijskih izvještaja, proračunski korisnici pripremaju i izvještaje o izvršenju proračuna te često postoji nesklad između propisanih izvještaja zbog primjene različite računovodstvene osnove. U brojnim zemljama prisutan je dvojni sustav izvještavanja te su provedena istraživanja u tim zemljama ukazala na činjenicu da se preferira korištenje izvještajima o izvršenju proračuna prilikom donošenja odluka. Nadalje, svrha je rada utvrditi preferiraju li javni menadžeri korištenje izvještajima o izvršenju proračuna više nego propisanim financijskim izvještajima. Također, uzimajući u obzir da su prethodno provedena istraživanja ukazala na činjenicu da postoji razlika u korištenju i korisnosti izvještaja javnoga sektora, istraživanjem će se utvrditi je li percepcija korisnosti propisanih izvještaja veća od korištenja. Istraživanje je provedeno metodom ankete na uzorku javnih menadžera i računovođa u javnom sektoru u Republici Hrvatskoj. Utvrđeno je da financijski izvještaji ne zadovoljavaju u potpunosti potrebe javnih menadžera te se reforme u računovodstvu javnog sektora u Republici Hrvatskoj očekuju u bliskoj budućnosti.
PROCESS MATURITY OF CROATIAN COMPANIES
Authors:   Sveučilište u Zagrebu, Ekonomski fakultet, Milanović Glavan Ljubica
Published: June 2023

Poduzeća današnjice pokušavaju poboljšati svoje performanse usredotočujući se na perspektivu orijentacije na poslovne procese. Ova perspektiva promatra poduzeća kao mješavinu ujedinjenih poslovnih procesa. Prepoznavanje različitih razina procesne orijentacije može pomoći poduzećima da izvrše, poboljšaju i upravljaju svojim procesima. Postoji nekoliko metodologija koje se mogu koristiti za analizu stanja zrelosti procesne orijentacije. Model zrelosti pokazuje stupanj prihvaćanja procesne orijentacije u poslovnoj praksi određenog poduzeća. Istraživanje u ovom radu ima za cilj izvijestiti o zrelosti procesne orijentacije u poduzećima Republike Hrvatske i naglasiti važnost procesnih elemenata. Za analizu rezultata odgovora prikupljenih anketom koristi se metoda klaster analize koja je pokazala kako su hrvatska poduzeća trenutno pozicionirana između definirane i povezane faze zrelosti procesne orijentacije. Takvi rezultati provedenog istraživanja ukazuju na to kako poduzeća u Hrvatskoj moraju unaprijediti sve elemente procesne orijentacije u svrhu napredovanja u više faze procesne zrelosti.
EFFICENCY OF REGIONAL LABOUR-MARKETS IN CROATIA
Authors:   Ekonomski institut, Zagreb, Kovač Tibor
Published: June 2023

Ovaj rad istražuje ravnotežne razine nezaposlenosti Hrvatske i njezinih županija. Koristeći se metodologijom o efikasnoj razini nezaposlenosti, rad za svrhu ima ispitati koliko su promatrana tržišta rada udaljena od svoje efikasne razine, pri kojoj je rasipanje resursa prilikom traženja i nuđenja zaposlenja smanjeno. Rezultati upućuju da je od 2004. do 2021. efikasna razina nezaposlenosti u Hrvatskoj iznosila 13,78% te da je stvarna razina nezaposlenosti u prosjeku bila 4 postotna boda viša od efikasne. Nakon recesije tržište rada u Hrvatskoj postaje napeto. Županije istočne Hrvatske najbliže su efikasnim razinama nezaposlenosti, ali su one iznimno visoke. Takvi rezultati upućuju na dublje strukturne probleme na tom području. S druge strane, županije središnje i sjeverne Hrvatske imaju, u prosjeku, najniže efikasne razine nezaposlenosti, ali i najveći negativni Beveridgeov jaz, što ističe potrebu za kreiranjem migracijske politike kako bi se odgovorilo na potrebe tržišta rada.
Classification of internal defects of gas turbine blades based on the discrimination of linear attenuation coefficients
Authors: Zhang Lei , Li Bing , Chen Lei , Shang Zhongyu , Liu Tongkun
Published: June 2023

In the process of manufacturing and servicing gas turbine blades, various types of defect are formed and grow rapidly due to the extremely harsh working environment, which poses a huge threat to the safe operation of the gas turbines. Given that different types of defect cause varying
degrees of damage to the turbine blades, it is vital to distinguish and deal with defects differently. Considering the shape of the blade (free-form surface) and the location of the defect (inside the blade), digital radiographic imaging can be used for the non-destructive testing of turbine
blades. Although some types of defect (for example porosity and cracks) can be distinguished from others (for example voids and inclusions) based on differences in morphological and textural characteristics, others (for example voids and inclusions) may be misclassified due to similarities
in morphological and textural characteristics. These defects with similar morphological characteristics are composed of different materials, which can be utilised as a basis for classification. This paper presents a classification method for defects with similar morphological characteristics
based on the discrimination of linear attenuation coefficients. Several typical defects, including voids and inclusions, are set into a cuboidal block and into nylon blades in this work. Their corresponding linear attenuation coefficients are obtained. A binary classification of the linear
attenuation coefficient enables the categorisation of voids and inclusions. Experimental results demonstrate that the proposed method has high efficiency and the judgement for voids and inclusions is accurate.
Submacular Choroidal Granuloma from Sarcoidosis: A Case Report
Authors: Duker Jacob S ,   Janigian Retina Associates, Providence, RI, USA, Vakharia Priya ,   Retina Vitreous Associates of Florida, Tampa, FL, USA, Duker Jay S ,   Tufts University School of Medicine, Boston, MA, USA, Rifkin Lana ,   Ophthalmic Consultants of Boston, Boston, MA, USA, Shah Chirag P ,   Ophthalmic Consultants of Boston, Boston, MA, USA
Published: June 2023

Introduction: This article reports two cases of submacular choroidal granuloma from sarcoidosis, highlighting the critical importance of timely diagnosis and treatment for both visual and systemic prognosis. Case studies: Case 1 is a 60-year-old man who presented with blurred vision from a submacular choroidal granuloma. Initially, the lesion responded to oral prednisone, however, there was progression once the prednisone was stopped. One year later, he developed complete heart block and was diagnosed with cardiac sarcoidosis. He underwent pacemaker implantation and has been maintained on mycophenolate. Case 2 is a 35-year-old man who presented with distortion from a submacular choroidal granuloma that similarly responded to oral prednisone but progressed after it was discontinued. He had a chest computerized tomography scan and a subsequent lymph node biopsy that confirmed the diagnosis of sarcoidosis. He has remained stable and healthy, with 20/20 vision on methotrexate. Conclusion: Submacular choroidal granuloma from sarcoidosis is a rare condition that can cause vision loss if not treated promptly. These lesions usually respond to local or systemic corticosteroids. Diagnosis of these lesions is critical not only for visual preservation but also to prevent systemic complications.
Comportamiento alimentario y actividad física en estudiantes universitarios durante la pandemia por Covid-19
Authors: Galeano-Morínigo Vanessa Romina , Martínez-Rolón Evelyn Rocío , Burgos-Larroza Rodrigo Octavio , Meza-Paredes Johana Vanessa
Published: June 2023

Debido a la pandemia del COVID-19 se modificaron los hábitos del estilo de vida afectando a todas las personas. En el caso de los estudiantes generó todo tipo de emociones, incertidumbres y estrés impactando en la ingesta de alimentos, libertades de desplazamiento y otros factores que pueden afectar su salud general. El objetivo fue determinar el comportamiento alimentario y el nivel de actividad física de estudiantes de la Facultad de Ciencias Químicas durante los meses de junio y julio del 2021. Se realizó un estudio cuantitativo observacional descriptivo transversal y el tipo de muestreo fue no probabilístico de casos consecutivos por bola de nieve. Se utilizó una encuesta virtual adaptada de Márquez et al. y el cuestionario Internacional de Actividad física (IPAQ), en el cual participaron 242 universitarios. Esta investigación contó con la aprobación del Comité de Ética de la Facultad de Ciencias Químicas de la Universidad Nacional de Asunción con resolución N° 669/2021. Se observó que el 90% de los estudiantes tenían comportamientos alimentarios saludables. El 55% presentó un nivel bajo de actividad física o era inactivo, el 87% permanecía más de 4 horas sentado en un día hábil. La mayor parte de los estudiantes presentaron un comportamiento alimentario saludable, pero al tener un nivel de actividad física bajo o inactivo y pasar más de 4 horas sentado en un día hábil, es preocupante ya que representa un factor de riesgo para desarrollar enfermedades crónicas no transmisibles.
Para una participación política ciudadana saludable es necesario gestionar la infodemia
Authors: Fuertes-Bucheli Jose Fernando , Fuertes-Bucheli Keilly Andrea
Published: June 2023

La participación política de los ciudadanos requiere que estos estén bien informados. Sin embargo, debido al ecosistema de información desigual, el analfabetismo digital y la pobre ética de algunos influyentes, se ha generado un ambiente perfecto para la infodemia y desinformación, que ha impactado negativamente en el bienestar de las comunidades. Por lo tanto, para tener una participación política ciudadana saludable, es necesario gestionar la infodemia. En este manuscrito se proponen estrategias de gestión de infodemia en salud, capaces de gestionarla en el ejercicio de la participación ciudadana.
The Overview of Eating Patterns and Dental Caries Status of The Community of Pendul, Argorejo, Bantul Yogyakarta
Authors: Utami Sri , Pinastika Retnaningtyas , Astuti Novitasari Ratna , Adiningrat Arya
Published: June 2023

The primary caries etiology factors are hosts (teeth), agents (microorganisms), substrates, and time. Individual characteristics can be influenced by caries' risk factors, such as age, education level, economic status, and diet. The high frequency of food and snack consumption, especially cariogenic food, is riskier of being caries affected. This study aims to describe the eating pattern and dental caries status of the Pendul community in 2018. This research is a descriptive observational study with a cross-sectional approach. It was held from December 2018 to January 2019 in the Pendul district of Bantul. The subject of this research was selected using the accidental sampling method with 138 respondents. The research instrument employed the Food Frequency Questionnaire and DMFT index. The result showed that the higher the consumption of cariogenic foods is, the higher the caries index will be. The highest frequency of cariogenic foods consumption was snacks, with a mean DMFT index of 8,02. The highest frequency of cariogenic beverage consumption was sugar tea, with a mean DMFT index of each respondent was 8 teeth. The highest frequency of cariogenic consumption per week lay in snacks and packaged tea.  Apart from the four etiological factors, such as agent, host, substrate, and time, caries can also be caused by other determinant factors such as gender, age, education level, and socioeconomic status.
Analysis of Water Consumption in the Context of Public Health and Economics: The Case of Ankara
Authors: GÜNER Ümit , PAMUK Rifat , AKSOY Şemsi Mustafa
Published: June 2023

This study aims to examine water consumption, which is the most basic necessity of people, within the framework of public health and economics. While water is an important economic research topic because it is the most important and most widely used economic good, it is also one of the most common medical research topics in the context of public health since it is consumed by all individuals of all societies. The use of packaged water in places where healthy tap water is inaccessible has positive effects on public health. On the other hand, the use of unnecessary packaged water is a very important public health problem in today's global world as it means more plastic waste. In our study, one of the most important variables affecting the consumption of packaged water, the parameter of trust in tap water, was analysed in Ankara by associating it with the concept of income level. As a result of the statistical analyses, it was determined that there was no statistical relationship between the income level with the use of packaged water and trust in tap water variables. In addition, it has been determined that there is a negative relationship between trust in tap water and packaging water usage variable. This result refuted the established claims that income level is the main determinant of water consumption preference.
Assessment of the Effect of Psoriasis and Methotrexate Treatment on Liver Stiffness by ARFI Imaging
Authors: GÜÇLÜ Derya , KARAGÜN Ebru , UNLU Elif Nisa , OKTAY Mehtap , PASİN Özge
Published: June 2023

Objective: To investigate whether psoriasis and methotrexate used in its treatment cause liver fibrosis and eventually to evaluate the safety of methotrexate in treatment.

Method: 44 cases were included in the study. Methotrexate-using (group 1, n=14) and methotrexate-not-using (group 2, n=13) psoriasis patients were compared retrospectively with a healthy control group (group 3, n=17) according to mean shear wave rates obtained from sonoelastographic examinations with ARFI technique.

Results: Mean shear wave velocities were calculated as 2.57 ± 1.13 m/sec in the patients using methotrexate, 2.31 ± 1.16 m/sec in the patients who did not use methotrexate, and 1.56 ± 0.62 m/sec in the healthy control group. While the average shear wave velocity of the 3rd group was found to be significantly lower than that of the 1st and 2nd groups (p=0.032; p=0.012), no significant difference was observed between the 1st and 2nd groups (p=0.755).

Conclusion: We think that the increase in liver tissue stiffness in patients using methotrexate for psoriasis is secondary to the inflammatory process caused by psoriasis itself rather than methotrexate, and methotrexate is safe for the liver in treatment.
La excepción por delito o fraude al privilegio abogado-cliente: privilegios probatorios y la lucha contra la corrupción en Estados Unidos
Authors: Bartholomew Christine P.
Published: June 2023

El artículo se centra en el estudio de la figura del crime fraud exception o “excepción por delito o fraude”, creada en los Estados Unidos, que tiene como fin ser una herramienta para combatir la corrupción, mediante la eliminación, en ciertos casos, de la reserva de la doctrina de producto del abogado o del propio privilegio abogado-cliente. En primer lugar, el artículo esboza los elementos sobre los que puede recaer la excepción, para luego determinar su naturaleza y alcance. Luego, determina sus aspectos procedimentales, en pro de su invocación y, finalmente, analiza su impacto previo y retos futuros en cuanto a su aplicación frente a la corrupción financiera y política. Concluye señalando que la excepción por delito o fraude es una herramienta poderosa en la lucha contra la corrupción, siempre y cuando se facilite su activación por parte de los abogados.
El impuesto de alumbrado público en el precedente del Tribunal Administra¬tivo del Valle del Cauca: 2019 a 2021
Authors: Chamorro Benavides Ana María
Published: June 2023

En el presente trabajo de investigación se analiza el precedente judicial del Tribunal Administrativo del Valle, desde 2019 hasta 2021, en cuanto al impuesto de alumbrado público, para determinar si encaja en el precedente de la Corte Constitucional y el Con­sejo de Estado.
Análisis jurídico de la aplicación por parte de la Unidad de Gestión Pen¬sional y Parafiscales (UGPP), de los artículos 118 y 119 de la Ley 2010 de 2019, a trabajadores independientes con obligaciones en firme
Authors: Escobar Catalina Yaver
Published: June 2023

La evasión en los aportes al Sistema de la Protección Social en Colombia se ha reduci­do de 24,19 billones de pesos en el 2012 a 3,61 billones en el 2021 como consecuencia de la implementación, por parte de la Unidad de Gestión Pensional y de Parafiscales (UGPP), de acciones persuasivas y procesos de fiscalización. Adicionalmente, se han implementado estrategias y mecanismos de recaudo, tales como los denominados be­neficios tributarios que permiten a los aportantes acceder a la reducción de intereses y sanciones siempre que cumplan con los requisitos exigidos por el legislador. Una de las leyes más icónicas en este aspecto ha sido la Ley 2010 de 2019 que estableció en sus artículos 118 y 119 las figuras de conciliación judicial y terminación por mutuo acuerdo, pero, además, conforme al artículo 139, permitió que los trabajadores independientes por cuenta propia y con contrato diferente al de prestación de servicios a quienes se les hubiere aplicado el esquema de presunción de costos para el cálculo del Ingreso Base de Cotización (IBC), vía revocatoria directa, a solicitud de parte o de oficio, accedieran a las mencionadas reducciones, sin perjuicio de que la obligación estuviera en firme.

En ese orden de ideas, en el presente escrito se realiza una categorización jurídica de las figuras contenidas en los artículos mencionados de la Ley 2010 de 2019 desde el punto de vista de los modos de la extinción de las obligaciones y los efectos suscitados por dichas figuras en el sistema tributario dentro de los cuales se advierte una disminución en el porcentaje de evasión, en lo que respecta a los trabajadores independientes, en el subsistema de salud, pasando del 45,2 % en el año 2019 a 38,4 % en el año 2020 y 38,1 % en el 2021.
THE COMPETITION INFRINGEMENTS iN LINER MARITIME TRANSPORT: ANANALYSIS BASED ON THE EU AND TURKEY*
Authors: TOMUR Huriye Dilbeste
Published: June 2023

This article aims ta reveal the competition issues in maritime transport and the harmonization of the arrangements between the EU and Turkey. The harmonization process is examined by comparing the relevant provisions in competition law, namely Article 101 and 102 in Treaty on the Functioning ofthe European Union (TFEU) and in Article 4 and 6 in the Law on the Protection of Competition Na. 4054. The impacts of cartel infringement and abuse of a dominant position in the !iner maritime transport is evaluated.
СУТНІСТЬ АУТСОРСИНГУ ЯК НОВОЇ МОДЕЛІ ОРГАНІЗАЦІЇ БІЗНЕСУ ТА ЙОГО ЗНАЧЕННЯ ДЛЯ РОЗВИТКУ МІЖНАРОДНИХ ВІДНОСИН
Authors: Маковоз О. В. , Зайцева А. С.
Published: June 2023

Аутсорсинг - це не «гра в одні ворота». У ньому зацікавлені і вузько спеціалізовані компанії, що надають послуги. Як правило, вони належать до числа дрібних компаній. Аутсорсинг - модель  господарювання, яка сприяє розвитку малого підприємництва. При цьому зростає кількість малих підприємств, збільшується чисельність зайнятих сфері, невеликий капітал переміщається з торгівлі в сферу виробництва, в інноваційний бізнес та ін. Аутсорсинг дозволяє посилити спеціалізацію всіх компаній. Будь-яка фірма (організація, підприємство, окремий індивідуум) отримує можливість зосередитися на своєму основному діловому процесі: виробництві високотехнологічних «розширених продуктів» за індивідуальними запитами споживачів, виробництві знань, виробництві нових ідей, технологій, рішень. Дана стаття присвячена уточненню сутності аутсорсингу як нової моделі організації бізнесу та його значення для розвитку міжнародних  відносин.
СУТНІСТЬ, МЕТОДИ ТА МОДЕЛІ ESG-ІНТЕГРОВАНОГО АНАЛІЗУ ЦІННОСТІ ТРАНСПОРТНОЇ КОМПАНІЇ
Authors: Портний О. В.
Published: June 2023

Розглянуто питання ціннісно-орієнтованого управління в контексті ESG-філософії. Зазначено, що філософія екологічного, соціального, корпоративного управління передбачає урахування ESG-критеріїв, завдяки чому економічний розвиток компаній демонструє стійке зростання фінансових показників і набуває ознак сталості. За результатами дослідження змісту і систематизації ESG підходів, методів і моделей узагальнено концептуальні засади ESG-інтегрованого аналізу цінності транспортної компанії.