bluuebunny/crossref_metadata_2025 huggingface dataset:
Breves considerações sobre o legado de Hogan
Authors: Seixas Sonia Regina da Cal
Published: October 2021

O presente artigo tem como objetivo primordial refletir sobre a contribuição do trabalho pioneiro de Daniel Hogan para a consolidação da temática socioambiental na Universidade Estadual de Campinas (UNICAMP). Em função de sua vasta produção intelectual seria impossível abordá-la por completo neste espaço, desta forma, optou-se por destacar um recorte pessoal de obras impressas e projetos considerados seminais e representativos para esta abordagem. Ressalta-se que a tarefa de realizar essa escolha não foi fácil em função da magnitude e abrangência da obra deixada por ele, com sua atuação ímpar em várias frentes e abordagens sobre a temática socioambiental em suas diferentes dimensões. No entanto, nossa escolha está centrada na constituição da dimensão socioambiental a partir das Ciências Sociais, que ofereceu importantes aportes teóricos nas últimas décadas, servindo como base para inúmeros trabalhos, projetos de pesquisas, formação de acadêmicos e a consolidação de um espaço privilegiado de atuação que se mantém até hoje como referência desta tradição, que é o Núcleo de Estudos e Pesquisas Ambientais – NEPAM – da UNICAMP, do qual foi um dos fundadores e coordenador no período de 1991 a 1997.
Significados produzidos por futuros professores de Matemática ao estudar diferentes modelos geométricos
Authors: Santos Junior Clovis Lisbôa dos , Maia Lícia de Souza Leão
Published: October 2021

Recorrente nas discussões científicas acadêmicas e, consequentemente, nas investigações da área em Educação Matemática, o estudo de Geometrias não Euclidianas na formação inicial do professor de Matemática pode ampliar a compreensão dos licenciandos acerca de conceitos geométricos euclidianos. No presente artigo, apresentam-se os resultados de uma Atividade de Ensino aplicada a futuros professores de Matemática, com o objetivo de analisar a produção de significados dos participantes no estudo de conceitos geométricos não euclidianos. A Teoria Histórico-Cultural de Vygotsky, complementada pela Teoria da Atividade de Leontiev e pela Atividade Orientadora de Ensino de Moura são os aportes teóricos que subsidiaram a investigação e as ações pedagógicas neste estudo. Ao aceitarem a existência de outros modelos geométricos, os licenciandos investigados modificaram a maneira como se relacionam com o espaço em que vivem e, assim, desenvolvem maior autonomia no processo de construção dos conceitos atribuindo significados diferenciados para os objetos geométricos estudados.
Conhecimento especializado do professor que ensina matemática relativo ao tópico de divisão
Authors: Policastros Milena Soldá , Ribeiro Miguel
Published: October 2021

Assumindo que o conhecimento do professor exerce um papel crucial em sua prática e nas aprendizagens dos alunos e por ser a divisão um dos tópicos mais problemáticos para professores e para alunos, focamos nossa atenção no conteúdo do Conhecimento Especializado, revelado em um curso de especialização relativamente a este tópico, por professores que atuam desde a Educação Infantil. O material coletado das interações dos professores, ao discutirem uma tarefa para a formação, foi analisado segundo a lente do Mathematics Teachers’ Specialized Knowledge, com intuito de caracterizar o conteúdo do Conhecimento Especializado do professor no tópico de divisão. Dessa análise, emergiram descritores do Conhecimento Especializado do professor de e que ensina matemática relacionado a conceitos, procedimentos, propriedades, fundamentos e sistemas representacionais no âmbito da divisão, contribuindo para que, nos contextos formativos, sejam intencionalmente implementados instrumentos eficazes para desenvolver tal conhecimento.
High Red Cell Distribution Width and Low Absolute Lymphocyte Count Associate With Subsequent Mortality in HCV Infection
Authors: Damjanovska Sofi , Davitkov Perica , Gopal Surya , Kostadinova Lenche , Kowal Corrine , Lange Alyssa , Moreland Anita , Shive Carey , Wilson Brigid , Bej Taissa , Al-Kindi Sadeer , Falck-Ytter Yngve , Zidar David , Anthony Donald D.
Published: October 2021

Background: Hepatitis-C virus (HCV) chronic infection can lead to cirrhosis, hepatocellular carcinoma (HCC), end-stage liver disease, cardiovascular disease (CVD), and mortality. Transient Elastography (TE) is used to non-invasively assess fibrosis. Whether immune monitoring provides additive prognostic value is not established. Increased red-cell distribution width (RDW) and decreased absolute lymphocyte count (ALC) predict mortality in those without liver disease. Whether these relationships remain during HCV infection is unknown. 
Materials and Methods: A retrospective cohort of 1,715 single-site VA Liver Clinic patients receiving Transient Elastography (TE) 2014-2019 to evaluate HCV-associated liver damage were evaluated for RDW and ALC in relation to traditional parameters of cardiovascular risk, liver health, development of HCC, and mortality.
Results: The cohort was 97% male, 55% African American, 26% with diabetes mellitus, 67% with hypertension, and 66% with tobacco use. After TE, 3% were subsequently diagnosed with HCC, and 12% (n=208) died. Most deaths (n=189) were due to non-liver causes. The TE score associated with prevalent CVD positively correlated with atherosclerotic cardiovascular disease (ASCVD) 10-Year Risk Score, age, RDW, and negatively correlated with ALC. Patients with anisocytosis (RDW above 14%) or lymphopenia (ALC level under 1.2x109/L) had greater subsequent all-cause mortality, even after adjusting for age, TE score, and comorbidities. TE score, and to a modest degree RDW, were associated with subsequent liver-associated mortality, while TE score, RDW, and ALC were each independently associated with non-liver cause of death.
Conclusion: Widely available mortality calculators generally require multiple pieces of clinical information. RDW and ALC, parameters collected on a single laboratory test that is commonly performed, prior to HCV therapy may be pragmatic markers of long-term risk of mortality.
Perspective of Indonesian Pediatricians on the Role of PrebioticSupplemented Formula towards Immunity, Growth and Development in Preterm Infants: A Preliminary Data
Authors: Sitorus Nova Lidia , Dilantika Charisma , Basrowi Ray Wagiu
Published: October 2021

ABSTRACT Background: Immature immune system in preterm infants is associated with gut dysbiosis and poses significant health risks to their growth and development. Current guidelines for managing preterm infants focuses solely on macro- and micronutrients, whereas preterm infants’ gastrointestinal system requires optimalization to support nutrient absorption. Studies on the positive impacts of prebiotics as supplements have been conducted, but has not been implemented in Indonesia. Indonesian pediatricians’ perspective on these findings needs to be assessed. Objectives: To describe the perspectives of Indonesian pediatricians on the role of gut microbiota balance in supporting immunity, growth, and development of preterm infants, and the role of breastmilk and prebiotic-supplemented formula in optimizing gut microbiota balance. Methods: A cross-sectional study was conducted on 114 Indonesian pediatricians using a previously-validated and previously-used questionnaire on the role of gut microbiota balance on preterm infants, as well as the role of breastmilk and prebiotic-supplemented formula in optimizing gut microbiota balance. Results: Most respondents agreed that gut microbiota balance supports immunity, growth, and development of preterm infants. Respondents also agreed that breastmilk contains nutrients that support gut microbiota balance and when breastmilk becomes unavailable, prebiotic-supplemented formula can be given as substitute. Conclusions: Indonesian pediatricians considered gut microbiota balance to be important for immunity, growth, and development of preterm infants, and breastmilk to be the most ideal source of nutrition for preterm infants in optimizing gut microbiota balance. When breastmilk is unavailable, prebiotic-supplemented formula can be considered as an alternative.
Transformasi Sumber Daya Manusia Perpustakaan dalam Menghadapi Era Revolusi
Authors: . Suhernik
Published: October 2021

Saat ini kita berada pada era revolusi industri 4.0, dimana kita dihadapkan pada sebagian besar pekerjaan diselesaikan berdasarkan system (robotic). Sebagai lembaga ilmiah Perpustakaan harus bertransformasi mengikuti perkembangan teknologi agar dapat menjawab kebutuhan masyarakat. Perilaku pengguna perpustakaan telah berubah mereka menginginkan sumber informasi dengan cepat, tepat dan mudah, bahkan tanpa kehadiran secara fisik mereka ingin mendapatkannya. Maka tak ayal lagi perpustakaan harus memasang strategi yang tepat guna agar tidak ditinggalkan oleh pemustakanya. Perpustakaan harus inovatif dan kreatif, dalam menyediakan sumber informasi dan layanan sesuai dengan kebutuhan masyarakat saat ini, dan didukung sumber daya manusia yang handal.
Literasi Saham pada Mahasiswa STIESIA Surabaya
Authors: Christian Mahendra Rizal
Published: October 2021

STIESIA Surabaya sebagai kampus ekonomi mendukung kegiatan investasi saham dengan mendirikan Galeri Investasi BursaEfek Indonesia. Dengan kenaikan jumlah investor setiap tahunnya, Galeri Investasi Bursa Efek Indonesia menyelenggarakan kegiatan literasi saham yang bekerja sama dengan Perpustakaan STIESIA Surabaya. Tulisan ini bertujuan membahas mengenaibagaimana literasi saham pada mahasiswa STIESIA Surabaya, bagaimana kegiatan investasi saham mampu meningkatkankesejahteraan investor, serta peran Perpustakaan STIESIA dalam literasi saham. Tulisan ini tidak menggunakan metode penelitian,namun menggunakan kajian literatur textbook, website dan artikel. Adapun hasil dari tulisan ini adalah Perpustakaan STIESIAmemiliki peran dalam literasi saham di STIESIA Surabaya seperti melakukan bimbingan penelusuran informasi yang berkaitandengan saham, menyediakan bahan pustaka yang berkenaan, serta sebagai media promosi pemanfaatan Galeri Investasi Bursa Efek Indonesia. Diharapkan tulisan ini mampu memberikan inovasi baru dalam dunia perpustakaan untuk melakukan kerja sama dengan unit kerja yang lain..
Implementasi Crowdsourcing dalam Dunia Perpustakaan
Authors: Puspitasari Dewi
Published: October 2021

Dunia sangat cepat bergerak. Ada suatu fenomena gotong royong oleh anggota masyarakat untuk satu tujuan tertentu. Setiap orang berhak dan diperbolehkan memberikan informasi yang diperlukan. Fenomena tersebut disebut sebagai crowdsourcing.Crowdsourcing merupakan konsep yang melibatkan masyarakat secara luas dan tidak terbatas dengan latar belakang etnis, warga negara, pendidikan, agama, jenis kelamin ataupun pekerjaan. Tulisan ini akan membahas bagaimana konsep crowdsourcing dapat diimplementasikan ke dalam perpustakaan. Sebagaimana jamak diketahui perpustakaan merupakan lembaga nirlabayang menyediakan jasa layanan informasi kepada pemustaka. Pemustaka atau bahkan masyarakat secara luas dapat ikut serta memberikan ide, gagasan atau pendapat dalam rangka mempromosikan perpustakaan. Aktivitas tersebut antara lain adalah: (1) Resensi oleh para pemustaka; (2) Komen/rekomendasi pemustaka mengenai suatu koleksi yang telah dibaca; (3) Magang di perpustakaan; (4) Library volunteer; (5) Pemustaka ikut serta membuat subject guide
Perawatan dan Pelestarian Bahan Pustaka di Perpustakaan Universitas Airlangga
Authors: . Turwulandari , . Noviyanti
Published: October 2021

Perpustakaan sebagai penyedia informasi harus dapat menyediakan bahan pustaka yang bermanfaat untuk penggunanya Untuk menyediakan bahan perpustakaan yang berkualitas dan mewujudkan perpustakaan sebagai sumber informasi bagi pemustaka, perlu dijaga agar bahan pustaka tersebut tidak rusak baik dari segi fisik maupun isinya. Karena itulah perpustakaan harus melakukan perawatan bahan perpustakaan. Untuk dapat melakukan perawatan bahan pustaka, maka perpustakaan harus dapat melakukan survei terhadap bahan pustaka tersebut diantaranya yaitu melihat kondisi bahan pustaka tersebut. Di Perpustakaan Universitas Airlangga perawatan dan pelestarian bahan pustaka dilakukan dengan cara sebagai berikut melakukan penjilidan dan melakukan fumigasi.
Transformasi Layanan Disabilitas pada Perpustakaan Perguruan Tinggi di Era 4.0
Authors: Wahyuni Wahyuni
Published: October 2021

Perkembangan teknologi informasi melahirkan revolusi industri yang saat ini memasuki era revolusi industri 4.0. Revolusi industri 4.0 berhubungan dengan big data yang berkembang sangat pesat sehingga pertumbuhan teknologi sangat cepat. Hal ini berdampak juga dalam dunia perpustakaan, yang tentunya harus bisa menyesuaikan dengan zaman dalam memberikan layanan kepada pemustaka. Pemustaka perpustakaan saat ini diharapkan juga mampu menjadi perpustakaan ramah bagi penyandang disabilitas, sehingga penyandang disabilitas juga bisa memanfaatkan perpustakaan dengan nyaman. Perpustakaan diharapkan bertransformasi dengan menyediakan kemudahan akses informasi kepada penyandang disabilitas, dengan bantuan teknologi informasi, sarana dan prasarana, fasilitas yang sesuai dengan karakteristik penyandang disabilitas. Perpustakaan juga mendukung tersedianya pustakawan yang siap membantu pemustaka disabilitas dengan memberikan pelatihan bagaimana memberikan pelayanan bagi penyandang disabilitas.
Phytodiversity of agroforestry systems with coffee trees and degree of Loranthaceae infestation in the department of Daloa (Central-West, Côte d'Ivoire)
Authors:   Agroforestry Training and Research Unit, Jean Lorougnon Guédé University, PO Box, 150 Daloa, Côte d’Ivoire, Anoh Denis-Esdras AMON , Hamed El Amine SAKO , Agnero Stephane MRANKPA , Fofana SEGUENA , Bernadin DRO , Kouadio Henri KOUASSI , Dodiomon SORO
Published: October 2021

The floristic condition of the agroforestry systems established on coffee trees in Daloa, in the Central-West of the Côte d'Ivoire has been carried out. Surface surveys and itinerant surveys identified 123 species, 93 genera and 37 families. Euphorbiaceae and Moraceae are the most represented families. The study made it possible to count 52.03% of the species of the Guinean-Congolese region, 27.65% of the transition species (GC-SZ), 11.3% of the indeterminate species, 5.69% of the endemic species West African and 2.44% of the GCI block species. The degree of infestation of plant species evaluated shows that the values vary from 8.33% at Alchornea cordifolia to 79.17% in Spondias mombin. The results also indicated a significant difference between the degrees of infestation of plant species according to the DBH, the age of the coffee plantations. The rate of infestation of plant species is 33.35±9.84% and the intensity of infestation is 2.83±0.60 tufts/plant. The analysis of the degree of infestation among others of Albizia zygia, Cecropia peltata, Cola nitida, Persea americana, and Spondias mombin has made it possible to identify major problems of Loranthaceae infestation sources posed by the presence of these species in coffee plantations.
Gnaphalium pulvinatum Delile (Asteraceae): A new record for the flora of Kachchh district, Gujarat, India
Authors:   Department of Earth & Environmental Science, Krantiguru Shyamji Krishna Verma Kachchh University, Bhuj-Kachchh, Gujarat - 370001 India, Kazbanu A. Sumra , Kishan I. Prajapati , Jignasaba R. Jadeja , Paurav K. Mehta
Published: October 2021

Gnaphalium pulvinatum Delile (Asteraceae) has been reported first time as a new record to the flora of Kachchh district from ‘Kundh’ pond of Ratiya forest of Bhuj taluka. A description, distribution and detail photographs of the species are provided to easy identification.
Diversity of climbers in Vallanadu Black-buck Sanctuary, Tuticorin, Tamil Nadu
Authors:   Department of Botany, Rani Anna Government College for Women, Tirunelveli, Tamil Nadu – 627 008, India, A. Saravana Ganthi , K. Subramonian , K. Natarajan
Published: October 2021

In climbers the stems are weak and these plants need various climbing devices in order to support growth and development. The climbers are predominately angiosperms. The present study chiefly focuses on diversity of climbers in Vallanadu Black-buck Sanctuary. The present study recorded 28 herbaceous climbers and 14 lianas from the scrub forest of Vallanadu Black-buck sanctuary. In dicotyledons, 15 families containing 33 genera and 40 species were recorded. In monocotyledons, 2 families containing 1 genus and 1species each were recorded. The present study reported invasive species such as Ipomoea obscura, Ipomoea pes-tigridis, Clitoria ternatea and Passiflora foetida. The present study recorded 24 medicinal climbers. Conservation of climber and lianas is the need of the hour and climbers provide valuable germplasm as medicinal plants for the benefit of humankind.
INOVASI MODEL VALUE CLARIFICATION TECHNIQUE (VCT) BERBASIS MEDIA WINDOWS MOVIE MAKER SEBAGAI UPAYA REVITALISASI NILAI PADA PEMBELAJARAN PENDIDIKAN NILAI DAN NORMA
Authors: Widodo Susilo Tri , Hadi Susilo , Abidin Ha. Zaenal
Published: October 2021

Penelitian ini bertujuan untuk mengembangkan model pembelajaran value clarification technique (VCT) berbasis media windows movie maker sebagai bentuk inovasi dalam pembelajaran mata kuliah Pendidikan nilai dan norma. Pembelajaran VCT merupakan model pembelajaran yang dapat digunakan untuk menunjukkan dan membangun nilai-nilai yang penting untuk dikembangkan pada setiap diri individu dalam kehidupan bermasyarakat, berbangsa dan bernegara. Pembelajaran ini dilakukan dengan dukungan video yang menjadi salah satu media pembelajaran untuk mendukung revitalisasi nilai. Penelitan ini dilaksanakan di jurusan Pendidikan Guru Sekolah Dasar, Fakultas Ilmu Pendidikan, Universitas Negeri Semarang. Subyek penelitian ini adalah mahasiswa. Penelitian ini merupakan penelitian pendidikan dengan pendekatan pengembangan. Hasil penelitian yaitu peneliti sudah melakukan studi pendahuluan dengan memetakan capaian pembelajaran lulusan, capaian pembelajaran mata kuliah, dan kemampuan yang diharapkan dalam mata kuliah Pendidikan Nilai dan Norma yang cocok didukung dengan model pembelajaran VCT dengan media video movie maker. Kelayakan Model pembelajaran VCT berbasis Media Windows Movie Maker terlihat dari hasil uji kelayakan validator yang menunjukkan bahwa rancangan model dapat diujikan di kelas treatment dengan kategori layak digunakan dalam penelitian. Keefektifan Model pembelajaran VCT berbasis Media Windows Movie Maker dapat dilihat dari hasil uji  dikelas treatment dengan pola one group pretest posttest design menunjukkan hasil pretest dan posttest terjadi peningkatan hasil belajar dari 45,69% menjadi 88,12%, jika dihitung dengan rumus N-Gain mendapatkan hasil 0,78 yang berarti terjadi peningkatan dalam kategori tinggi, sedangkan melalui angket kefektifan inovasi model menunjukan bahwa terjadi peningkatan kefektifan pembelajaran sebelum dan sesudah menggunakan inovasi model pembelajaran terjadi peningkatan dari 53,49% menjadi 89,15%.

 

Kata kunci : VCT, media windows movie maker, pembelajaran, nilai dan norma
PENGUATAN KARAKTER KEWARGANEGARAAN DI SMP MURNI 1 SURAKARTA MELALUI PEMBELAJARAN PPKN
Authors: Diana Faizah Nur , Winarno Winarno , Muchtarom Mohammad
Published: October 2021

Tujuan Penelitian ini adalah untuk (1) Mengetahui implementasi penguatan karakter kewarganegaraan di SMP Murni 1 Surakarta melalui pembelajaran PPKn dan (2) Mengetahui hambatan dalam proses penguatan karakter kewarganegaraan di SMP Murni 1 Surakarta melaui pembelajaran PPKn. Penelitian ini menggunakan metode kualitatif, karena penelitian ini tidak membuktikan atau menolak suatu hipotesis akan tetapi data yang diolah di deskriptifkan dan lebih menekankan makna dari pada generalisasi. Teknik pengambilan sampel yang digunakan dalam penelitian ini yaitu purposive sampling. Teknik pengumpulan data melalui wawancara, observasi, dan studi dokumen. Validitas data dalam penelitian ini menggunakan triangulasi data yaitu triangulasi data dan metode. Analisis data yang digunakan dalam penelitian ini adalah dengan model Milles dan Huberman yaitu reduksi data, penyajian data dan penarikan kesimpulan. Hasil penelitian menunjukan bahwa (1) Guru merancang RPP dengan memasukkan nilai-nilai karakter dalampembelajaran PPKn sebagai bentuk penguatan karakter kewarganegaraan, melakukan penguatan secara verbal dan non verbal baik dalam pembelajaran di kelas maupun di luar kelas, melakukan home visit untuk melihat lingkungan sekitar peserta didik, (2) Hambatan yang dihadapi oleh guru yaitu tidak adanya dukungan dari orang tua karena tidak memperdulikan perkembangan peserta didik, faktor ekonomi keluarga yang membuat peserta didik mempunyai sifat mudah membangkang karena keinginannya tidak terpenuhi, lingkungan tenpat tinggal peserta didik yang terkesan lingkungan kurang baik, dan peserta didik yang tidak kondusif pada saat pembelajaran di kelas.

 

Kata kunci: penguatan, karakter kewarganegaraan, pembelajaran
Strategi Penguatan Civic Literasi dalam Upaya Penanggulangan Hoax pada Masa Pendemi Covid-19
Authors: Suryaningsih Anis
Published: October 2021

Pandemi COVID-19 membuat berbagai sektor dalam negeri mengalami kesulitan. Satu permasalahan nyata yaitu maraknya hoax seputar kasus-kasus COVID-19 yang meresahkan warga masyarakat. Maraknya hoax yang menyebar luas membuat masyarakat luas mengalami panik dan cemas berlebihan, yang berujung pada permasalahan menurunnya tingkat kesehatan dan meningkatnya tingkat kriminal. Bertolak dari permasalahan tersebut dipandang perlu meningkatkan civic literacy bagi warga agar berwawasan Pancasila dalam menyikapi kasus hoax yang semakin banyak merebak. Civic literacy atau ‘melek kewarganegaran’ merupakan pengetahuan dan kemampuan untuk berpatisipasi secara efektif dalam hidup berkewarganegaraan seperti mengetahui bagaimana untuk tetap selalu update dalam menerima informasi, memahami pemerintahan serta mengetahui bagaimana menggunakan hak dan kewajiban sebagai warga masyarakat baik pada tingkat lokal, provinsi, nasional dan bahkan global. Civic literacy bagi warga Negara Indonesia yaitu paham dan sadar bahwa dasar negara Indonesia adalah Pancasila.  Warga yang paham dan mampu mengamalkan sila-sila dalam Pancasila membuat mereka bersikap lebih mawas diri dalam menghadapi pandemi COVID-19 ini.

 

Kata Kunci: civic literacy, Pancasila, COVID-19
Implementing basal reading program in EFL upper secondary school settings
Authors: Sajidin  , Mulyadi Dodi , Robiasih Hasti
Published: October 2021

Basal readers have been selected by the school to cope with students’ lack of vocabulary size. With some positively perceived learning outcomes, the readers continued to be used from year to year and were decided as a school program, in addition to ELT national curriculum.  The research is aimed at exploring the following aspects: (1) the teacher’s use of basal readers in the classrooms, (2) the classroom procedures developed by the teacher understudy, and (3) the students’ response to the implementation of the basal reading program.  A descriptive case study with classroom observation as a main data collection technique was employed to explore the phenomena. The research brings several points to consider. First, basal readers have been extensively used by the school for different purposes: 1) for vocabulary enrichment, (2) for intensive reading materials, (3) as resource making classroom tests, and (4) a basis for writing phonetic symbols, and (5) for promoting speaking skills.  Second, the school has developed its own strategies to use the readers with specific procedures.  Third, the use of basal readers was positively responded to by the students with some suggestions for better implementation.

HIGHLIGHTS:

Basal reading program was implemented with a specific procedure developed by the local school English teachers.

Basal readers selected for the reading program were utilized to develop reading skills in which vocabulary memorization and pronunciation drills were used to support the skills.

The program was positively responded by the students with some suggestions for a better implementation.
GASTROPOD DRILLING PREDATION IN THE UPPER JURASSIC OF KUTCH, INDIA
Authors: SAHA RANITA , PAUL SHUBHABRATA , MONDAL SUBHRONIL , BARDHAN SUBHENDU , DAS SHILADRI. S , SAHA SANDIP , SARKAR DEBATTAM
Published: October 2021

Gastropod drillholes on prey shells provide an opportunity to test the importance of predation in an evolutionary context. Although records of drilling predation are widespread across the Phanerozoic, the temporal distribution and relative importance of this mode of predation is still controversial. Further, some studies indicate a decline of drilling predation in the Mesozoic but other studies do not. In this study, we present a new dataset of gastropod drilling predation on Kimmeridgian and Tithonian bivalves of Kutch, India. Our study suggests that drilling was one of the prevailing modes of predation in the Upper Jurassic of Kutch with strongly variable intensities, ranging from 2% in the Kimmeridgian Seebachia to 26% in the Tithonian Pinna. A significant, albeit small, increase in drilling intensity from the Kimmeridgian to the Tithonian assemblages is associated with a change in relative sea-level and depositional environment. The morphology of drillholes and recent discovery of body fossils from the same stratigraphic units suggest naticid gastropods as the most likely drillers. A literature survey, along with previously collected specimen from the Jurassic of Kutch, reveals a more complex history of drilling predation than previously assumed.
Through-Tubing Well Seismic: A Mast Campaign Across an Offshore Producing Field, Saudi Arabia-Kuwait Partitioned Neutral Zone
Authors: Yamaguchi Kaoru , Frignet Bernard G.
Published: October 2021

A multi-well VSP Through-Tubing campaign was conducted in order to survey 2 neighboring mature fields in the northern Arabian Gulf. Nine key wells were selected by the reservoir engineers and geophysicists from a total of more than 200 wells. The selection criteria included: (1) spatial distribution; (2) previous well data availability; and (3) completion type. At the planning stage it was estimated that 3 days (excluding night work for safety) would be required per well (one day to rig-up the mast, one day to acquire the seismic data and one day to rig-down). Local experience indicated that a single air gun would be an effective seismic source. A slimhole, monocable, single-axis geophone sonde was selected as the downhole seismic tool. The zero-offset VSP configuration, with 80 foot level-spacing from total depth to surface was adopted. A supply boat was dedicated for the duration of the campaign. The actual operation was completed in 24 days, 3 days earlier than planned. An average of 90% of the VSP levels were found suitable for first break detection, which provided accurate Time-Depth curves for all 9 wells. Geophone coupling quality is dependent on the Tubing-Casing contact. The tube wave is developed at all 9 wells; but, overall 80% of the levels were selected for VSP processing. In 5 wells, where sonic logs had been acquired, synthetic seismograms were generated which confirmed the validity of VSP reflections. The data is now integrated in a 3-D velocity model.
Educación virtual en odontología durante la pandemia de COVID-19
Authors: Guevara-Veliz Darlyng Nicolle , Flores-Joaquin Keyla Margorin , Maturrano-Santos Alex Gianmarco , Mattos-Vela Manuel Antonio
Published: October 2021

Los cambios en la educación universitaria que surgieron en el contexto de la pandemia de COVID-19 supusieron nuevos retos en todo el mundo. En el caso de la educación odontológica, si bien ya se había intentado la implementación de recursos virtuales, un enfoque completamente virtual fue un nuevo desafío. El objetivo de este artículo es discutir sobre la educación virtual en el área odontológica en el contexto de la pandemia de COVID-19 y los retos que representa. Se concluyó que, para lograr la continuación de la educación dental en una modalidad virtual, las estrategias más usadas por muchas universidades fueron las plataformas académicas Moodle y, para realizar las videoconferencias, Google Meet y Zoom. Asimismo, la percepción de esta nueva modalidad, tanto de docentes y estudiantes en su mayoría fue buena; sin embargo, se enfatiza que estas no reemplazan la necesidad de las actividades presenciales para desarrollar sus capacidades como futuros odontólogos.
Caracterización de exodoncia de terceros molares
Authors: Baeza Solange , Cáceres Nathaly , González Gustavo , Guzmán Carolina , Sepúlveda María Paz , Valenzuela Isidora
Published: October 2021

El objetivo de este estudio fue caracterizar las principales situaciones de indicación, contraindicación y accionar profiláctico para la exodoncia de terceros molares, según la literatura. Se utilizaron las bases de datos PubMed, Scopus y Web of Science, con un total de 3 llaves de búsqueda, y se incluyeron publicaciones de máximo 5 años de antigüedad, en inglés o español, con disponibilidad de texto completo. Fueron seleccionados 18 artículos, en los que se determinó que la indicación más frecuente en la exodoncia de terceros molares fue el diagnóstico de pericoronaritis, seguido de caries cervical distal en segundo molar inferior, reabsorción radicular en dientes adyacentes y quistes. A su vez, puede estar indicada para facilitar otros tipos de tratamientos dentales, como ortodoncia, cirugía ortognática y rehabilitación. En cuanto a las contraindicaciones, predominó el riesgo de complicaciones intraoperatorias asociadas con el nervio alveolar inferior, edad avanzada y compromiso sistémico. El 72,2% de los artículos incluía en su análisis la extracción profiláctica, y se observa una predominancia de exodoncia de terceros molares asintomáticos y libres de enfermedad. Finalmente, la evidencia señala situaciones claras de indicaciones y contraindicaciones en torno a la exodoncia de terceros molares. Estas se asocian, principalmente, con cambios patológicos, indicaciones por tratamientos de ortodoncia, cirugía ortognática y tratamientos rehabilitadores. Sin embargo, existe controversia en la literatura respecto de la exodoncia profiláctica, y se destaca que no todos los terceros molares retenidos y asintomáticos deben extraerse. Es necesario evaluar caso por caso, considerando los beneficios de la práctica, las características del paciente y el riesgo de complicaciones posoperatorias.
A novel strategy for degree design in amblyopia with anisometropia and ametropia
Authors: Wang Chuanyu , Li Zhiwei , Mu Guoying
Published: October 2021

Objective

To propose a novel strategy for degree design in amblyopia with anisometropia and ametropia.
Methods

28 patients with refractive amblyopic eye visual acuity ranging from 20/666 to 20/29 (45 eyes) were provided with optical correction followed by the maximum plus to maximum visual acuity (MPMVA) and amblyopic training. After which, the patients were supposed to test acuity improvement at the 3-month, 6-month, and 12-month visit.
Results

At the initial 3-month visit and 6-month visit, visual acuity improvement from the spectacle-corrected baseline acuity averaged 1.5 ± 1.00 lines and 2.0 ± 1.10 lines respectively. Moreover, the data demonstrated that the age and baseline acuity both inversely related to the visual acuity improvement (P = 0.093, P < 0.001, at 3-month visit; P = 0.080, P < 0.001, at 6-month visit). And it showed there are no relationship between type of anisometropia and ametropia and acuity improvement at 3-month visit (P = 0.315), while they were relevant at 6-month visit (P = 0.025).
Conclusion

From another point of view, we proposed a new notion to reveal secret of amblyopia. The study directed by the principle based on the new notion showed that getting the degree to MPMVA and following by amblyopic training in amblyopia with anisometropia and ametropia can improve visual acuity effectively.
Health Information from Management to Technology: Development of a Radiology Patient Safety Monitoring System
Authors: Karami Mahtab , Hafizi Nasrin , refahi soheila
Published: October 2021

Background: Medical imaging is an intervention through which patient safety (PS) is of great importance. In monitoring PS, the major challenges include lack of relevant data, proper control, and appropriate feedback in taking the necessary measures. To meet these deficiencies, the related data should be investigated precisely and advanced technology should be applied to monitor the quality of imaging.Objective: The purpose of this study was to design and develop a PS monitoring system at the radiology department to mitigate adverse events.Methods: This developmental research was conducted in multiple phases including content determination using Delphi technique, conceptual modeling using Rational Rose software, database designing using SQL Server, user interface (UI) building using Agile software, and system evaluating in three aspects of UI requirements, the accuracy of calculating, and usability. Results: In this study, 110 PS-related important data elements were identified in 14 main groups and 26 PS performance metrics, as the system contents. The ERD and UML diagrams were drawn and the UI was created in three tabs: pre-procedure, intra-procedure, and post-procedure. Finally, the evaluation results proved the technical feasibility and application prospect of the radiology patient safety monitoring system (RPSMS). Finally, the usability of the system was highly rated (76.3 from 100).Conclusion: The RPSMS, offers the possibility to complement the datasheets for gaining a more accurate picture of the PS status and bringing up its aspects, which might otherwise go unnoticed or be underestimated by clinicians.
The Essential Role of Nuclear β-Catenin Translocation in the Osteoblastic Differentiation of GCTB: Prediction of Tumor Ossification After Denosumab Treatment
Authors: Kimura Atsushi , Toda Yu , Matsumoto Yoshihiro , Yamamoto Hidetaka , Yahiro Kenichiro , Shimada Eijiro , Kanahori Masaya , Fukushima Suguru , Nakagawa Makoto , Setsu Nokitaka , Endo Makoto , Fujiwara Toshifumi , Matsunobu Tomoya , Oda Yoshinao , Nakashima Yasuharu
Published: October 2021

Denosumab is a game-changing drug for giant cell tumor of bone (GCTB); however, its clinical biomarker regarding tumor ossification of GCTB has not been elucidated. In this study, we investigated the relationship between Wnt/β-catenin signaling and the ossification of GCTB and evaluated whether endogenous nuclear β-catenin expression predicted denosumab-induced bone formation in GCTB. Genuine patient-derived primary GCTB tumor stromal cells exhibited osteoblastic characteristics. Identified osteoblastic markers and nuclear β-catenin translocation were significantly upregulated via differentiation induction and were inhibited by treating with Wnt signaling inhibitor, GGTI-286, or selective Rac1-LEF inhibitor, NSC23766. Furthermore, we reviewed the endogenous ossification and nuclear β-catenin translocation of 86 GCTB clinical samples and elucidated that intra-tumoral ossification was significantly associated with the nuclear translocation. Three-dimensional quantitative analyses (n = 13) of tumoral CT images have revealed that the nuclear β-catenin translocation of naïve GCTB samples was significantly involved with the denosumab-induced tumor ossification. Our findings suggest a close relationship between the nuclear β-catenin translocation and the osteoblastic differentiation of GCTB. Investigations of the nuclear β-catenin in naïve GCTB samples may provide a promising biomarker for predicting the ossification of GCTB following denosumab treatment.
CKAP2L, a Crucial Target of miR-326, Promotes Prostate Cancer Progression
Authors: Li Qi , Yan Mo , Wang Chunhui , Kan Duo , Wang Kaibin , Bao Guochang
Published: October 2021

BackgroundThe overexpression of aberrant cell cycle signaling pathway associated protein has been implicated in multiple malignancies and the identification of all-important one among is the crux of the precise targeted therapy. CKAP2L (Cytoskeleton Associated Protein 2 Like) plays a newish role in cancer progression through activation of the process of cell cycle and mitosis. In this study, we aim to delineate the prominent dysregulated expression of CKAP2L and comprehensively reveal its deregulation in prostate cancer.MethodWe experimentally manipulated CKAP2L gene expression in vitro and in vivo and monitored its effects on cancer-related gene expression, cell migration, proliferation.ResultsIn multiple datasets, CKAP2L was found upregulated and positively associated with Gleason grade and poor clinical outcomes of patients. shRNA mediated silence of CKAP2L suppressed cell proliferation, impaired monolayer formation, inhibited cell invasion. CKAP2L was confirmed to be the direct target of miR-326, which had a carcinostatic effect by binding the 3’untranslated regions (3’UTRs) of CKAP2L mRNA. The deletion of CKAP2L resulted in reduced expression of genes involved in the mitotic cell cycle such as multiple cyclin-dependent kinases and cyclins, but also several genes encoding proteins involved in chromosome segregation and spindle assembly. ConclusionTaken together, miR-326 plays a carcinostatic role in prostate cancer by reducing the expression of CKAP2L .
Hesperidin inhibits biofilm formation, virulence and staphyloxanthin synthesis in methicillin resistant Staphylococcus aureus by targeting SarA and CrtM: An in vitro and in silico approach
Authors: Karuppiah Vijayakumar , Seralathan Muhilvannan , Mani Arunvignesh
Published: October 2021

Methicillin resistant Staphylococcus aureus is considered the multidrug resistant bacterium due to developing biofilm formation associated with antimicrobial resistance mechanisms. Therefore, inhibition of biofilm formation is an alternative therapeutic action to control MRSA infections. The present study revealed the non-antibacterial biofilm inhibitory potential of hesperidin against ATCC strain and clinical isolates of S. aureus. In addition, hesperidin treatment significantly impedes lipase, hemolysin, autolysin, autoaggregation and staphyloxanthin production. Reductions of staphyloxanthin production possibly increase the MRSA susceptibility rate to H2O2 oxidative stress condition. In gene expression study revealed the hesperidin treatment downregulated the biofilm-associated gene (sarA), polysaccharide intracellular adhesion gene (icaA and icaD), autolysin (altA), fibronectin-binding protein (fnbA and fnbB) and staphyloxanthin production (crtM). Molecular docking analysis predicted the ability of hesperidin to interact with SarA and CrtM proteins involved in biofilm formation and staphyloxanthin production in MRSA.
Association Between Dietary Total Antioxidant Capacity and Hypertension in Pre- and Postmenopausal Women; Finding From RaNCD Cohort Study
Authors: Fateh Hawal Lateef , Mirzaei Narmin , Gubari Mohammed Ibrahim Mohialdeen , Darbandi Mitra , Najafi Farid , Pasdar Yahya
Published: October 2021

Background: Diet is one of the influential factors in developing hypertension. Moreover, the role of antioxidants in the prevention of cardiovascular diseases (CVDs) has been identified. Total antioxidant capacity (TAC) is a valid tool to assess intake antioxidants from diet. The aim of this study was to examine the association between TAC and hypertension in pre- and postmenopausal women.Methods: In this cross-sectional study was used baseline data of the Ravansar Non-Communicable Disease (RaNCD) cohort study. The TAC was calculated using food items of the food frequency questionnaire. Univariable and multivariable logistic regression were applied to estimates odds ratio. Results: A total of 5,067 women were included in the study. The mean daily intake of refined grains, legumes, white meat, nuts, omega-3, and omega-6, vitamins of B1, B2, B6 and D were significantly higher among women non-hypertensive compared to hypertensive (P<0.05). Multivariate logistic regression showed the odds of hypertension in the third quartile of dietary TAC was 0.71 (95% CI: 0.52, 0.96) times and the fourth quartile of dietary TAC was 0.73 (95% CI: 0.53, 0.98) times lower compared to the first quartile, in pre/perimenopausal women. There was no association between TAC and hypertension in postmenopausal women.Conclusion: A high dietary TAC was associated to a decreased risk of hypertension in pre/perimenopausal women. We suggest a diet rich in natural antioxidants as it may help prevent developing of hypertension before menopausal.
Transcriptomic Time Series Analysis in Wound Healing: Challenges and Perspectives on Data Interpretation
Authors: Zlobina Ksenia , Malekos Eric , Chen Han , Gomez Marcella
Published: October 2021

Background: Wound transcriptomic analysis can be used to quantify wound healing stages and identify leverage points for wound healing intervention. However, individual gene signatures corresponding to wound healing stages vary from one experiment to another and are highly dependent on both experimental setup and bioinformatics methods. Methods: We develop a systematic approach to informatively compare time series from publicly available wound transcriptomic datasets, including mouse and human wounds, and identify consistent gene expression patterns. Results: We reveal the limitations of gene expression data collection, interpretation, and comparison. For example, the sample rate of wound transcriptomic sample collection must be higher than the rate of changes in the wound healing processes, otherwise, important changes in gene expression may be missed. This may lead to mis finding the most significant genes, as peaks of expression for highly differentially expressed genes are lost. Nevertheless, we derived a short list of genes highly differentially expressed in all datasets under consideration. After clustering and normalization, these genes clearly demonstrate similarly changing dynamics of expression between the wounds and may be used for wound healing stage detection.Conclusions: A list of genes that may be used for transcriptomics-based wound healing stage detection is provided. In addition, we suggest experimental approaches that could help researchers to extract more meaningful results.
Practices of Sickle Cell Disease Genetic Screening and Testing in the Prenatal Population
Authors: Prince Arianna , Cruz-Bendezú Alanna , Gunawansa Nicole , Wade Jenna , Coleman-Cowger Victoria H. , Schulkin Jay , Macri Charles
Published: October 2021

Background

Genetic screening and testing has only recently become an accessible assessment for genetic risk. Unfortunately, these technologies have been underutilized in minority populations despite their usefulness for predicting diseases like sickle cell disease (SCD), often found in African American and Black and Hispanic populations. We surveyed prenatal patients to understand current choices, beliefs and experiences surrounding genetic screening and testing, specifically for sickle cell disease.
Methods

In this cross-sectional survey, we collected information from 322 women during prenatal visits from July 2019 through May 2021. Responses to questions about pregnancy screening and testing practices were analyzed for trends to identify barriers to care and education about testing and screening for sickle cell disease. Patients were asked to rate whether they agree or disagree with statements regarding sickle cell health behaviors. We used χ2 tests to compare categorical variables by self-reported race. Binary logistic regression was used to determine the odds ratios and confidence intervals for each outcome.
Results

Women were a mean (SD) age of 33.3 (6.1). 42.9% of patients self-identified as White while 41.3 of patients self- identified as African American/Black. Screening questions were adjusted for differences in race, insurance, and education levels to show significant differences in responses between African Americans/Blacks and Whites for screening for SCD (p=0.047, OR 95% CI= 0.455 [0.210-0.989]) and plans to meet with genetic counselors (p=0.049, OR 95% CI = 0.299 [0.090-0.993]). Regarding sickle cell health behaviors, only the responses to the statements about if sickle cell is not in their family, then it is likely not in themselves or their children, and partners' opinions about genetic screening remained significant (p=0.011 and p=0.081, respectively).
Conclusions

Our findings suggest gaps in screening, testing, and educational efforts between African American/Black and White patients, as well as differences in opinions regarding pregnancy management with a family history or gestational diagnosis of sickle cell disease. Future research should focus on decreasing these healthcare gaps and improving education that address concerns about SCD for relevant populations.
The structural effects on silver nanoparticles plasma edges in optical reflectance spectra of Ag/Ag2O composites synthesized by oxygen plasma treatment of silver thin films
Authors: Kayed Kamal Hamed
Published: October 2021

In this work, we present the results of a unique study that aims to detect the structural effects on the plasma edges in optical reflectance spectra of Ag/Ag2O composites synthesized by treating silver thin films manufactured by thermal evaporation method with oxygen plasma afterglow. The results showed that, each of the optical reflectance spectra contains two plasma edges, the first (λI) belongs to the surface plasmons of the individual silver nanoparticles, and the second (λL) belongs to the larger silver nanoparticles. In addition, we found that the positions of the plasma edges are linearly related to the positions of the optical absorption peaks, except for high and low oxidation rates cases. On the other hand, taking into account previous work, we obtained indications that, the ratio NI/NL may be a measure of the film's effectiveness in inhibiting bacteria.
Prognostic Nomogram to Predict the Overall Survival of Patients with “driver-gene-negative” Lung Adenocarcinoma (LUAD) and Its’ Biological Basis Deciphering
Authors: Zhu Ying , Yang Hao-Shuai , Shan Shi-Chao , Guo Qi-Kun , Liu Zhen-Guo , Chang Dan-Dan , Luo Honghe , Lei Yi-Yan , Ke Zun-Fu
Published: October 2021

Objectives: Assessing the prognosis of patients with “driver-gene-negative” lung adenocarcinoma (LUAD patients negative for EGFR, KRAS, BRAF, HER2, MET, ALK, RET and ROS1 were identified as “driver-gene-negative”) is of significant clinical importance. We aimed to devise a prognostic nomogram for this LUAD subgroup and to define its biological basis.Materials and methods: Prognostic nomogram were established based on a retrospective study of 294 patients with surgical resected “driver-gene-negative” LUAD at The First Affiliated Hospital of Sun Yat-sen University between September 2003 and June 2015. The concordance index (C-index) and calibration curve were used to determine its predictive accuracy and discriminatory capacity. Patients were classified into low- and high-risk subgroups according to nomogram scores. To define the biological basis, we carried out gene set enrichment analysis in an independent dataset of 49 “driver-gene-negative” LUAD patients.Results: The nomogram built on the independent factors including CTC, age and stage achieved C-index of 0.785 [95% confidence interval (CI) 0.753-0.817] for predicting OS of “driver-gene-negative” LUAD. The calibration curves for OS probabilities showed a good agreement between the nomogram prediction and actual observation. High-risk patients had shorter OS [hazard ratio (HR) = 7.43, 95% CI 5.20-10.42, p<0.0001]. The genetic analysis suggested the biological basis for the role of the predictive model may be due to changes in cell proliferation, metabolism and neurological disease, indicating a relationship between increased proliferative potential and preferential poor prognosis.Conclusions: The prognostic nomogram showed promising prediction efficacy and is expected to predict the prognosis of “driver-gene-negative” LUAD. The easy-to-use nomogram and the enriched pathways can help clinical decision-making, guide follow-up planning, and develop new therapeutic targets.