bluuebunny/crossref_metadata_2025 huggingface dataset:
https://biotechnology.kiev.ua/index.php/en/journal-archive-en/2023-en/2023-no2-en/fibrinogen-specific-protease-in-the-vipera-renardi-snake-venom-k-v-baidakova-y-m-stohnii-o-m-platonov
Authors:   Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine, Kyiv, Taras Shevchenko National University, Kyiv, BEKALA M.I.
Published: June 2023

Aim. To investigate the changes in MMPs expression and activity as well as invasiveness of human lung adenocarcinoma A549 cells with up-/down-regulation of Ruk/CIN85. Methods. There were used A549 cells with stable overexpression (subline RukUp) and knockdown of Ruk/CIN85 (subline RukDown), as well as corresponding vector control sublines Mock and Scr. Cells were cultured in the complete DMEM medium under standard conditions. mRNA expression levels were estimated by RT2-PCR, enzymatic activity was assessed using gelatin zymography. Invasiveness of cancer cells was studied using Boyden chambers coated with Matrigel. Results. Analysis of mRNA expression of MMPs in RukUp and RukDown cells revealed that MMP-2 and MMP-9 were preferentially overexpressed in RukDown cells, while RukUp subline did not exhibit significant difference compared with corresponding control. These findings were confirmed and complemented by study of enzyme activities. The gelatinolytic activities of both MMP-2 and MMP-9 were dramatically increased in RukDown subline, compared to respective control. we revealed that MMPs regulation was inversely correlated with invasion potential of Ruk/CIN85 up/down A549 cells. In particular, it was established that invasiveness of RukUp cells was 2 times higher in comparison with respective control subline. Alternatively, invasion ratio was significantly decreased in RukDown cells (0,5 times) in comparison with control. Conclusions. According to the data received, it is possible to suggest that up-regulation of adaptor protein Ruk/CIN85 in A549 cells can lead to the very aggressive MMP-independent mode of migration that rely on cycles of expansion and contraction of the cell body mediated by the cortically localized actin and myosin.
THE SEARCH OF STRUCTURAL PATTERNS OF IVERMECTIN ALLOSTERIC INTERACTION WITH GLUTAMATE-GATED CHLORIDE CHANNEL OF Caenorhabditis elegans
Authors:   Institute of Food Biotechnology and Genomics of the National Academy of Sciences of Ukraine, Kyiv, KUSTOVSKIY Y.O. ,   National University of Kyiv Mohyla Academy, Ukraine
Published: June 2023

The aim of this research was to determine the structural patterns of IVM allosteric interaction with residues of its binding site located in the transmembrane domain of α-homopentameric glutamate-gated chloride channel (GluClα) of Caenorhabditis elegans. Methods. To consider different conformational states of IVM binding site two complexes of IVM bound to C. elegans GluClα (each with five site conformations) with identifiers 3RHW and 3RIF were obtained from PDB. The structures were examined in Analyzer Mode of SeeSAR v.12.1.0, in which contributions of IVM atoms into the complex affinity and their interactions with site structural patterns were determined for each site conformation using the HYDE scoring function. The residues belonging to identified structural patterns were classified by their properties using the Taylor’s classification of amino acids. Results. According to the results, the benzofuran group is critical for IVM recognition and binding: it interacts with the T-A-S-N-D-I-L-Q-I-P pattern, which is formed by T257, A258, S260, and N264 of M2, D277 and I280 of M3 of (+) subunit and L218, Q219, I222, P223 of M1 of (–) subunit. Due to the size and hydrophobicity of macrocycle, its different parts interact with residues of all site-forming structural elements mentioned above resulting in the V-I-G-A-M and I-V-D-L patterns. While the V-I-G-A-M pattern is formed by the residues of (+) subunit (V278, I280, G281, A282, and M284 of M3), the I-V-D-L pattern contains residues of both subunits: I273 of M2-M3, D277 and V278 of M3 of (+) subunit and L218 of M1 of (–) subunit. Finally, the spiroketal group interacts with M-T-F-C-M-I of (+) subunit (M284, T285, and F288 of M3) and (–) subunit (С225, M226, and I229 of M1). As opposed to other functional groups, the disaccharide is located outside of the binding site pocket. It interacts with I273 of M2-M3 of (+) subunit and L217, L218, and I222 of M1 of (–) subunit; however, considering that these residues are not united spatially, no pattern for the disaccharide can be determined based on the structural information which was analyzed. The determined structural patterns of IVM allosteric interaction with GluClα can be used in search of IVM binding site on its potential targets, in the development of hypotheses of IVM binding to identified sites, and to rationalize the drug design of new GluCl ligands. Conclusions. The structural patterns with high affinity for IVM functional groups have been determined based on the results of HYDE assessment and visual analysis of IVM-GluClα complexes and the possible implementations of patterns knowledge have been described. The identified patterns can be further corrected and extended using the structural information of other IVM targets deposited in PDB.
The effect of L-glutamic acid and N-acetylcysteine administration on biochemical blood parameters in rats treated with CCl(4)
Authors:   Institute of Animal Biology NAAS of Ukraine, Lviv, Salyha N. O.
Published: June 2023

A toxic organic substance CCl4 is a well known model compound for studying detoxification function of the liver and developing oxidative stress. The goal of the study was to estimate the effect of L-glutamic acid (L-Glu) and N-acetylcysteine (NAC) administration on rat blood parameters upon the toxic effects of CCl4. Experimental male Wistar rats were injected intraperitoneally with CCl4, the rats of CCl4/L‑Glu group were additionally injected with L-Glu (750 mg/kg), of CCl4/NAC group – with NAC (150 mg/kg), of CCl4/L-Glu/NAC group – with L-Glu (750 mg/kg) and NAC (150 mg/kg). The duration of the experiment was 24 h. Increased level of lipid peroxides, TBARS, triacylglycerols, cholesterol and decreased glutathione peroxidase, glutathione reductase, glutathione-S-transferase activity and GSH content were observed in the blood of the CCl4 treated animals compared to the control untreated group. When animals were additionally injected with L-Glu or L-Glu/NAC the most of the studied indicators were shown to be close to the control level These results suggest that the above mentioned aminoacids attenuated CCl4-induced oxidative stress in the blood of rats. Keywords: biochemical blood parameters, glutathione dependent enzymes, L-glutamic acid, N-acetylcysteine, oxidative stress, tetrachloromethane
Dynamics of CD68 receptor expression in macrophages of the interstitial space of the rat testis under triptorelin prolonged administration
Authors:   Department of Histology, Cytology and Embryology,Poltava State Medical University, Poltava, Ukraine, Stetsuk Ye. V. , Shepytko V. I. ,   Department of Histology, Cytology and Embryology,Poltava State Medical University, Poltava, Ukraine;, Akimov O. Ye. ,   Department of Pathophysiology, Poltava State Medical University, Poltava, Ukraine;
Published: June 2023

Testosterone, the production of which is stimulated by the release of luteinizing hormone (LH) has a remarkable anti-inflammatory and immunomodulatory effect, and in conditions of testosterone deficiency tissue damage can occur due to excessive differentiation of macrophages into a pro-inflammatory M1 phenotype. The aim of this study was to determine the spread of CD68 receptorn as the marker of inflammation on the cells in the interstitial space and testicular vessels under LH synthesis blockade with tryptorelin. Sexually mature white male rats were randomly divided into control (10 animals) and experimental (25 animals) groups. Animals in the experimental group were injected with a tryptorelin acetate solution (0.3 mg/kg). Immunochemical analysis of CD68+ expression was estimated at Olympus FV10i-LIV laser scanning confocal microscope using fluorescent labeling dye hilyte flour 488. It was shown that luteinizing hormone deprivation led to an increase in the distribution of the CD68 receptor in the interstitial space and in the testicular vessels from day 30 to 180 of the experiment, associated with the increase of inducible NO synthase activity in testis tissue. Keywords: CD68, luteinizing hormone, macrophage M1 phenotype, testis, testosterone, tryptorelin References:
Assessment of deforestation impacts on carbon sequestration in Edo State south Southern Nigeria
Authors: Aweh David Suru , Olotu Yahaya , Ibrahim Rasheed , Izah Linda Ngozi , John Arohunmolase Adeboye
Published: June 2023

The stocking and sequestering of increasing atmospheric carbon dioxide (CO2) and the reduction of greenhouse gas (GHG) emissions that result from improving the carbon sink are two important ways that forested land contributes to the fight against global warming. The purpose of the study is to estimate the rate of carbon sequestration (CS) in Edo State, Nigeria, as well as the volume of deforestation and its impact on CS. To gauge the changes in carbon stock, stock-difference and gain-loss methods were employed. The gain-loss method predicts gains and losses based on off-take and growth rates, while the stock-difference approach uses actual measurements of carbon stocks over a given period of time. These two methods presuppose that changes in carbon stock and CO2 flows to or from the atmosphere are equal. To quantify the decline of the forest, geographical studies and satellite imagery were used. Comparing the area covered by forest in the same region at two distinct eras allowed researchers to determine the annual rate of change. The outcome showed that tree cover loss (TCL, kg/ha) was decreased in 18 local government regions (LGAs). As a result, throughout the baseline consideration period of 2010 to 2022, Etasko East (EE) and Estako West (ES), Ovia South East (OSW), and Ovia North have had the least loss in tree cover. The increased demand on human survival brought on by the expanding population may provide an explanation for this observation and discovery. As a result of this development, forests underwent transformation and were used to produce food, build cities and homes, and generate energy. The region with the highest rates of tree cover loss and deforestation was associated with the highest CS, which was calculated at 2700 tC/ha at OSW, and the lowest CS value point at 22.2 tC/ha at Oredo Edo (OE). As a result, OSW showed that dense forests had higher biomass carbon storage than grazing land and open forests. In conclusion, the study showed that Edo State has a significant potential for raising the level of carbon sequestration in order for the state to generate a profit from the sale of carbon stock and enhance climate change mitigation efforts.
Metabolites from the soft coral -associated bacterium \(\textit{Micrococcus}\) sp. strain a-2-28
Authors: Pham Thi Mien , Wiese Jutta , Dao Viet Ha Dao Viet Ha
Published: June 2023

The marine actinomyces Micrococcus was the most common bacterium among the isolates corals, sponges, and alga isolates. Only a few investigations of natural compounds from Micrococcus sp. were reported previously. This study implicated the soft coral-associated Micrococcus sp. strain A-2-28 (following relative Micrococcus flavus LW4T) for large-scale cultivation, chemical analyses, and biological activities. Whereas crude extract of the strain A-2-28 inhibited only Staphylococcus epidermidis, metabolites profiles and pure compounds from strain A-2-28 showed that this strain produced phytohormone (IAA), metabolized some new compounds which were almost inactive for biological tests. This work suggested that it is possible to plan a new strategy for improving coral health and resilience though their associated microbial.
Research and assessment of potential groundwater exploitation reserves in coastal areas of Ninh Thuan province
Authors: Tran Thi Thuy Huong , Trinh Hoai Thu , Nguyen Van Hoang
Published: June 2023

This paper presents the results and assessment of the groundwater exploitation reserves in coastal areas of Ninh Thuan province. The research was based on determining the exploitation reserves of all grid cells with dimensions 500 m × 500 m distributed in fresh-salted water areas of the Holocene (qh) and Pleistocene (qp) aquifers. Each grid was assigned the corrected hydrogeological parameter values (depth, gravity coefficient, hydraulic conductivity, and drawdown level). The calculation results show that the total amount of potential exploitation reserves in the entire qh and qp aquifers-distributed areas is 561.8 × 106 m3 per day, whereas in the freshwater area is 345.4 × 106 m3 per day (61.5%), and the saline water area is 216.4 × 106 m3 per day (38.5%). These potential exploitation reserves can be used for groundwater exploitation management and planning in Ninh Thuan province.
PREDICTION OF EXPOSURE CONDITIONS IN VICINITY OF UMTS BASE STATION ANTENNAS
Authors: Wójcik D.
Published: June 2023

The rapid diffusion of wireless telecommunications has focused attention on potential risks for human health due to the exposure to electromagnetic (EM) fields. In context of cellular telephony the problem should be considered in two different aspects: possible health hazard due to hand-held phone devices or due to base station antennas, which this paper will be devoted to. To evaluate exposure condition in vicinity of Universal Mobile Telecommunication System (UMTS) base station antenna, the method based on the replacement of panel antenna with a discrete linear array and combined with the geometrical optics and uniform theory of diffraction
TECHNOLOGY OF CONTINUOUS MANUFACTURE OF ELECTRODES FOR LEAD-ACID BATTERIES
Authors: Dzenzerskyi V. O. , Burylov S. V. , Skosar V. Yu. , Skosar Yu. I. , Anikeiev Ye. V. , Neznanov M. O.
Published: June 2023

We have developed the technology of the continuous manufacturing of leads for lead-acid batteries. The said technology allows increasing the corrosion resistance, the mechanical strenght of leads and the lifetime of batteries.
THE INFLUENCE OF THE RAILWAY PLOT STATE AND STRUCTURE OF THE TRAIN FLOW IN THE LIFE CYCLE OF A TRACK
Authors: Kurhan D. M. , Bondarenko I. O.
Published: June 2023

The criterion of an estimation influence a rolling stock on a track which results in the end of a resource the basis under rails and necessities of replacement the top structure in view of a condition of a way and structure of a stream of trains on a site is offered.
MODERN APPROACHES TO TECHNICAL REGULATION OF THE RAILWAY
Authors: Lisohurskyi O. M.
Published: June 2023

In article modern problems in the field of development of technical plans of work of road and its structural divisions are considered. The analysis of existing methods of planning and their lacks is resulted at the organization of transportations in modern conditions. The characteristic of hierarchical levels of management, proceeding from restructuring a railway transportation is given. The system of classification of the parameters is resulted, allowing to detail the information on work of the railway and to apply it in mathematical models. Modern requirements to methodology of technical normalization are presented and basic elements of developed System of support of decisionmaking of technical normalization of work of road (СПР ТНЭРД) are described.
ONE QUEUING SYSTEMS WITH UNRELIABLE SERVICES DEVICES IN A TRANSITIONAL MODE
Authors: Poslaiko N. I.
Published: June 2023

A queuing system with unlimited line and unreliable service devices is considered. A computational technique of probabilities of stats of the system has been proposed.
RATIONAL IMPLEMENTATION OF THE MATHEMATICAL MODEL OF MOTION OF A MAGNETIC LEVITATING TRAIN
Authors: Poliakov V. O. , Khachapuridze N. M.
Published: June 2023

The expediency of dynamic systems motion models realization paradigm shift aside of their return problem decision is proved. The specified paradigm is developed for magnetic levitated train motion model.
FROM THE IT-EDUCATION TO WORK IN THE FIELD OF IT
Authors: Zhyltsova A. O.
Published: June 2023

This article is devoted to the problems of discrepancy between the content of the higher IT-education and requirements and expectations of employers in IT- sphere. The problem is worked out in detail in its different manifestations, and some ways to improve existing situation are proposed. Article also represents the description of informational portal dedicated to the higher and complementary education and also job placement as one of the elements of resolving existing problems.
MULTI-CHANNEL DIGITAL METHOD OF RELAYDIAGNOSTIC
Authors: Razghonov O. P. , Adreievskykh O. V. , Bondarenko B. M. , Bezrukavyi D. O. , Zhuravlev O. Yu.
Published: June 2023

The multichannel digital method diagnostics of relay consists in the use of experimentally findings, for the calculation of parameters of examinee relay. During registration of dynamic descriptions parallel on all channels, analog-to-digital treatment of results is produced, by the method of comparison with the admittances stopped up in memory of computer and is drawn conclusion about the good condition of device.
THE STUDY OF AUTOMATIC CONTROL SYSTEMS OF RHEOSTATIC BRAKING ON TRAINS ER2T
Authors: Visin M. H. , Sokolov S. A.
Published: June 2023

The article examines transitional process in the power circuit of tractive motors and their influence on the work of grading automatic breaking of EMU trains ER2T. Recommendations have been developed for increasing reliability of operations of multiple-unit rolling stock.
A MATHEMATICAL MODEL OF THE ACTUATOR PISTON COMPRESSOR WITH DK MOTOR 406 (DK 409) OF ELECTRIC TRAIN ER2
Authors: Dubynets L. V. , Ustymenko D. V. , Krasnov R. V. , Karzova O. O.
Published: June 2023

The mathematical model of the electric drive of the piston compressor with engine DK406 (DK409) is offered.
MATHEMATICAL MODELING OF TRANSIENT EMERGENCY ELECTROMAGNETIC PROCESSES IN THE SYSTEM OF ELECTRIC TRACTION OF DC
Authors: Kostin M. O. , Myhalichenko P. Ye.
Published: June 2023

The article deals with the description of the mathematical model the system traction electric power supply without loading in the short circuit condition and the result of the reserches this accident process. The transition quantity has been defined, and character their change too, which can use for the determined accidents processes.
THE DEPENDENCE OF THE FORMATION PROCESSES OF DEFORMATION BANDS FROM THE STRUCTURAL PARAMETERS OF LOW-CARBON STEELS AFTER THE ANNEALING
Authors: Vakulenko I. O. , Hryshchenko M. A. , Perkov O. M.
Published: June 2023

The causes of directionaty of the yield point, stress of microyielding, and Chernov–Luders deformation in lowcarbon steel have been investigated. The observed of Chernov–Luders deformation be haviour is considered to be the result of a directional variation in the grain size of berrite to cause formation dislocation cell structure.
DETERMINE THE MINIMUM RADIUS OF CURVES IN PLAN WITH REGARD TO THE DISTRIBUTION OF TRANSPORTATION
Authors: Kurhan M. B. , Zaiats M. A.
Published: June 2023

The technique of a substantiation of the minimal radius of a curve is stated at introduction of high-speed movement on the existing railway due to transfer of a part of a freight traffic on a parallel course.
FEATURES DIMENSIONS AND CONTENTS OF A RAIL TRACK ON A CONCRETE SLEEPERS
Authors: Matvetsov V. I. , Kovtun P. V. , Kebikov O. O. , Krupodrov V. P. , Miroshnykov N. Ye.
Published: June 2023

The basic stages of introduction on railways of cross ties from ferroconcrete are resulted. The data on rates of laying and extent of a railway on the ferroconcrete basis on Russian and Byelorussian railways are resulted. It is shown, that the width of a rail track at different levels from a surface of the head of a rail considerably differs be­cause of canting. The experimental researches confirming the conclusion are executed that existing practice of measurement of width of a rail track promotes its actual narrowing. The way of fastening of clip of an intermediate compound in stationary conditions and on the worked way is considered, allowing to prevent above permitted stan­dard narrowing of a rail track.
COMPARATIVE ANALYSIS OF METHODS OF CONTROL OF THE LONGITUDINAL STRESSES IN CONTINUOUSLY WELDED RAIL OF JOINTLESS TRACKS
Authors: Rybkin V. V. , Arbuzov M. O.
Published: June 2023

Comparison of the longitudinal stresses monitoring methods in continuous welded rails is made. It is determined, that the magnetic method is perspective.
THE MARKETING PRINCIPLES OF INCREASING THE ECONOMIC EFFICIENCY OF CONTAINER TRANSPORT
Authors: Muzykina H. I. , Beh P. V. , Bolvanovska T. V.
Published: June 2023

This article tackles the problem of necessity of the applying the marketing principles in the management activity. There were defined the main advantages and disadvantages the utilization of the middle-tonnage containers. The aspects of the existing tariff policy were revised as well. Under the conditions of the competitiveness between the different means of transport, in our opinion, the existing tariff policy need to be considerably revised and improved.
MODELING AND AUTOMATION OF LAND MANAGEMENT ON THE BASIS OF THE LAND REGISTRY
Authors: Movshyn D. I.
Published: June 2023

Basic tasks and it's mathematics models, which arise up during automation of processes of management the landed resources in Ukraine, are considered.
THE ESTIMATED COMPONENTS CHANGES TO DETERMINE THE DISTRIBUTION OF CAR TRAFFIC VOLUME ON THE RAIL NETWORK
Authors: Papakhov O. Yu. , Okorokov A. M. , Lohvinov O. M.
Published: June 2023

Trains forming plan constituents change Possibility, inclusions in them variable expense rates and time on supplementary carriages processing considers.
DYNAMIC LOAD AND WEAR CENTER PLATE ARRANGEMENT OF NODE FREIGHT CAR
Authors: Bobylkova E. O.
Published: June 2023

The method of wear calculation and calculation results of dynamical loading of elements in freight wagon center plate arrangement are present.
MODERN APPROACHES IN THE FIELD OF SAFETY OF RAILWAY TRANSPORT
Authors: Skogarev I. Ye. , Kobozev O. Ya. , Zhyzhko V. V. , Bohomazova Ye. O.
Published: June 2023

The article is devoted the actual questions of increase of safety of motion on a railway transport, namely introduction of education-testing programmatic complex. A programmatic complex is given by teaching possibility, verifications of knowledges of workers of railway with subsequent verification of the mastered material, and also possibility of timely organization of handing over of attestations.
SPECIAL ASPECTS OF WORKING METAL TRUSSES FROM THE WIND LOAD
Authors: Marochka V. V. , Verovka O. P.
Published: June 2023

There is a problem of simplified of computational models, which are used at calculation and designing of metal superstructures as a frame. Sometime it leads to the considerable errors in calculations. In this work researches of dimensioned behavior of a superstructure by a finite element method was implemented. In the capacity of calculated construction the standard superstructure (a type project №690/2) has been used. Ground obtained results the model for calculation of supplemental forces in chords was designed, which simulate a behavior of constructional.
RATIONALE DESIGNATED CONTROLLING COST
Authors: Voronkov Yu. V.
Published: June 2023

The paper in question described is the approaches to control of costs of various investigators. On the basis of the received results it is revealed, that the system of controlling provides the best control and the account of costs. Realization of the formulated recommendations will increase a degree of adaptation of the organizations to changing conditions of the market. It will have a positively affect to their industrial activity.
THE COMPETITIVENESS MONITORING OF RAIL TRANSPORT IN THE FREIGHT MARKET
Authors: Diachenko Yu. F.
Published: June 2023

The statistical data of volumes of goods transportation of railway transport of Ukraine for an last decade analyzed. The tendencies of growth of role of Oucrzaliznitsi are exposed at the market of freight transportations. The given recommendations on the rise of transit potential of railway transport of Ukraine.
DYNAMIC PROCESSES IN THE OPEN ECONOMIES
Authors: Zalizniuk D. V. , Ilman O. V. , Ilman V. M.
Published: June 2023

It is considered the concerned scheme of development of the dynamic processes in the opened economic systems at the certain hierarchical dependence, at the mathematics this dynamic process is describing as a system of the differentiable equations. There is an example of variations of the active resources at the opened isolated system.
THE NEED TO INTRODUCE LOGISTICS IN CONNECTION WITH RAILWAY REFORM IN UKRAINE
Authors: Koretska S. O.
Published: June 2023

On the basis of analysis of the transporting logistic systems of foreign companies in the article the represented most priorities and effective directions of the transporting logistic systems which must be developed today. In addition, four is described levels of development of the systems of logistic on a railway transport in Ukraine.
THE RESTRUCTURING PROCESSES INVESTIGATIONS OF THE RAILWAY INDUSTRY OF THE WORLD
Authors: Mishchenko M. I.
Published: June 2023

The processes of restmcturing of railways of different countries are explored, factors causing the necessity of re-stracturing are studied. The basic aspects of functioning of railway transport are analysed in modern terms and way of improvement of efficiency of implementation of basic types of activity and vehicular process on the whole.
SELECTION OF INNOVATION PROJECTS, WITH TAKING INTO ACCOUNT THEIR ADAPTIVE PROPERTIES
Authors: Savchuk R. V.
Published: June 2023

In clause use of a quantitative estimation of adaptive properties innovation of the projects for development of the concept of an estimation and choice of the priority design decisions of regional economic development is offered. The basic stages of technology of selection of the projects are determined in view of their adaptive qualities. The offered economic model allows to accept the proved decisions on investment of means in development of the enterprises of region.
THE OPTIMIZATION OF ENTERPRISE INVENTORY
Authors: Snachev M. P. , Stepanova M. S.
Published: June 2023

The article is devoted to research of the issue of the day of enterprises – optimization of supplies on storages. The methods of rationalization are considered, possibility of their application on the enterprises of Ukraine is analysed, conclusions in relation to application of that or other method in modern terms are also resulted.
NUMERICAL SIMULATION OF TRANSIENT PROCESSES OF THE GROUNDWATER CONTAMINATION
Authors: Kalashnikov I. V.
Published: June 2023

A numerical model to calculate the process of ground waters protection from pollution with the use of neutralizator has been proposed. The model is based on the 2-D equations of filtration and admixture transfer. Results of numerical experiment are presented.
THE SCHEME OF PIECE-WISE LINEAR UNIT AS A MATHEMATICAL MODEL OF PROCESS MODULES OF FLEXIBLE ASYNCHRONOUS THREAD OF REPAIR CARS
Authors: Myamlin V. V.
Published: June 2023

A variant of configuration of an enterprise using the asynchronous flexible stream of repair of wagons is suggested. A method of formalization of a process of functioning the technologic modules of asynchronous flexible stream of repair of wagons is considered. A general scheme of segment-linear aggregate as a mathematical scheme of functioning the technologic modules is proposed. The given mathematical scheme can be further a basis for development of various imitation models used in design and study of the asynchronous flexible stream of repair of wagons.
THE DETERMINATION OF THE EQUIVALENT CURRENT LOAD WHILE TESTING THE TRACTION MOTORS ON THE HEAT WITHOUT VENTILATION
Authors: Dubynets L. V. , Ustymenko D. V. , Loza P. O.
Published: June 2023

The theoretical determination procedure of an equivalent loading current in tests of traction electric motors on heating without ventilation is offered. The results of calculation of an equivalent current for traction engine ED-118A are presented, as well as the method accuracy is experimentally confirmed.
THE SIMULATION OF HEAVY GAS DISPERSION IN THE ATMOSPHERE
Authors: Pshinko O. M. , Biliaiev M. M. , Mashyhina P. B.
Published: June 2023

A numerical model to simulate the process of heavy gas transfer was developed. The numerical simulation is carried out using 3D models of pollutant transfer and potential air flow. The implicit finite difference schemes are used. The results of numerical simulation of air pollution are presented.
THE CALCULATION OF MULTICOMPONENT ROD SYSTEMS BY DECOMPOSITION METHOD
Authors: Raspopov O. S.
Published: June 2023

For decomposition of two- and three-dimensional rod systems the effective algorithm of dividing a system into blocks and the appropriate technique of coding for states of each from subsystems are developed. It is shown that the structure of multi-dimensional models can be set by means of space matrices based on the research of topological properties of the system graph.
THE FUNCTIONAL ANALYSIS AND SYNTHESIS OF THE CRITERIA FOR DANGEROUS FAILURES OF RAIL CIRCUITS OF VARIOUS TYPES
Authors: Cheptsov M. M. , Radkovskyi S. O.
Published: June 2023

In the paper the criteria of dangerous refusals of track circuits of different types are complemented by the time features.
THE REAL-TIME SYSTEMS, ANALYSIS OF POSSIBILITIES OF THEIR APPLICATION IN THE MANAGEMENT OF BURLY CONSTRUCTION MACHINES
Authors: Yakovlev S. O. , Khryshcheniuk S. I.
Published: June 2023

Presently computers are more utilized in the mode of batch processing or solution of separate jobs, which are loaded from the stand of operator. In spite of the fact that at present the advantages of the real-time systems and dialog modes of their functioning became obvious, too little attention is paid to  the problem of application of these progressive methods for the management of parks of building machines.
THE ESSENCE AND PURPOSE OF THE TRANSPORT NODES IN THE CONTEXT OF DEVELOPING INTERNATIONAL TRADE AND TRANSPORT STRATEGY OF UKRAINE
Authors: Volkanova N. D.
Published: June 2023

Ways of improving the efficiency of transport process management at a transport junction are investigated. The methods of introduction of the logistic technologies into the management process at a transport junction are suggested.
THE ALTERNATIVE MODELS OF REFORM OF UKRAINIAN RAILWAY TRANSPORT
Authors: Hrechko A. V.
Published: June 2023

In the paper a definition of management mechanism of railway transport enterprises is suggested. On the basis of this definition the basic models of reforming the railway transport of Ukraine are systemized.
THE IMPROVEMENT OF THE PAYMENTS SYSTEM FOR INTERNATIONAL CARGO TRANSPORTATION (FOR EXAMPLE, CIS AND BALTIC COUNTRIES)
Authors: Pryvalova L. V. , Bulgakova Yu. V.
Published: June 2023

The urgency of reduction of payment terms for international freight transportations, the development of offers aimed at reduction of terms of conducting payments for freight transportations and services related to them in international communication are considered in this paper.
CRITERIAL EVALUATION OF MEASURES FOR THE TRAFFIC ORGANIZATION
Authors: Lobashov O. O. , Burko D. L.
Published: June 2023

The issues of evaluation of activities upon the organization of traffic at the transport city network are being studied. The activities as to their social, ecological and economical efficiency rates are brought up to estimate.
THE PROBLEM OF DETERMINING THE LENGTH OF THE ZONES H-CHARACTERISTICS IN CALCULATING THE RELIABILITY OF TECHNICAL OBJECTS
Authors: Laguta V. V. , Kapitsa M. I.
Published: June 2023

Setting up a problem of determination of the zone lengths of a failure function is considered in the paper. Properties of a failure function and an intensity failure function are taken into consideration. The problem statement has been formulated as a structure definition problem.
THE USE OF THE ROLLING STOCK AUTOMATIC IDENTIFICATION SYSTEM FOR THE PROCESS CONTROL OF THE RAIL INDUSTRIAL ENTERPRISES
Authors: Shysh V. O. , Chykin Yu. M.
Published: June 2023

Outlooks of using the rolling stock automatic identification system (RSAIS) on the railway transport in the CIS and Baltic countries, the composition of RSAIS technical means and their positioning on the rail tracks of an industrial enterprise with a purpose of checking the technological processes of operation of the railway facilities are considered. The stages of RSAIS implementation program at an industrial enterprise are discussed.
TO THE QUESTION ABOUT THE FORMATION OF OZONE HOLES IN THE ATMOSPHERE AND THE PRESENCE OF THE AREAS WITH THE LOWEST VALUES OF TEMPERATURE
Authors: Ivin V. F.
Published: June 2023

The article represents the new theoretical model of formation of ozone holes in atmosphere of the Earth and areas with the lowest values of air temperature and the forecasts concerning change of climatic conditions on the Earth in the future.
A STUDY OF AN ORDER IN RAPID RESPONSE TO EMERGENCIES IN THE DANGEROUS GOODS TRANSPORTATION BY RAIL
Authors: Radkevych A. V. , Yakovlev S. O. , Shaptala O. I. , Kramar I. Ye.
Published: June 2023

The paper is devoted to the problems of determination of rules and order of application, interaction of subdivisions of the State Special Service of Transport with subdivisions of the Ministry of Transport and Communications of Ukraine and the Ministry of Ukraine on Issues of Extraordinary Situations and in Affairs of Population Protection from the Aftermaths of Chernobyl Catastrophe during elimination of aftermaths of accidents with dangerous freights on the railway transport.
ON THE NEED FOR ESTABLISHMENT OF LOGISTICS CENTERS IN UKRAINE
Authors: Muzykina S. I.
Published: June 2023

The Western companies consider the lack of logistic powers as the main obstacle for activities in the markets of the Eastern Europe in general andUkrainein particular. The same problem makes our country less attractive for international cargo transit.
THE EFFECT OF TOLERANCES ON SWITCHING TRACTION MOTORS TRANSIENT
Authors: Dubynets L. V. , Shapovalov A. V.
Published: June 2023

Dependence of the traction engine sparking degree on practical realization of tolerances on geometric parameters of the magnetic circuit of additional poles under transition modes during the trolley take-off from contact mains and further recovering the feeding is shown in the article.
THE IMPROVED POWER PROPERTIES OF THE TEST BENCH FOR THE COLLECTOR OF TRACTION ENGINE
Authors: Loza P. O.
Published: June 2023

In this article the expediency and ways of improvement of power parameters of the test stand for the driving collector motors of locomotives are considered.
TECHNOLOGICAL VARIABLES OF RATIONING RESOURCES FOR TRANSPORTATION ON THE RAILROAD
Authors: Mykhalchenko O. O.
Published: June 2023

The basic components of the resources directed on performance of transportation process on the railway are presented. The basic technological variables used in rating of resources for the railway primary activity are determined.
THE INTERMEDIATE RAIL FASTENING CAT-5 IN KAZAKHSTAN
Authors: Fink V. K. , Kosenko S. A.
Published: June 2023

In the article the issues of testing the parts of a fastening КПП-5 on reliability are considered and the modem way of fixing the backing anchor in a form at a factory of ferro-concrete sleepers is presented.
THE CONCRETE STRUCTURES DESIGN WITH RATIONAL GRAIN STRUCTURE COMPONENTS
Authors: Netesa M. I. , Palanchuk D. V.
Published: June 2023

The problems of utilization of the secondary products of industry in the concretes and increase of efficiency of the use of cement providing the rational composition of components are considered.
THE APPLICATION OF TOPOLOGICAL METHODS TO THE CALCULATION OF THE SPATIAL OSCILLATIONS OF TWO - AND THREE-DIMENSIONAL TRUSS SYSTEMS
Authors: Raspopov O. S.
Published: June 2023

The methods based on the theory of terminating graphs and finite state machines are applied to examination of the space oscillations of rod and beam constructions with distributed parameters. The high performance of topological analysis of the graphs representing two-and three-dimensional rod systems is demonstrated. The secular equations for joint oscillations of the orthogonal system of intercrossed girders with rigid nodal junction are obtained.
THE DETERMINATION OF RATIONAL PARAMETERS OF THE NOMINAL MODE OF THE TRACTION MEANS OF RAIL TRANSPORT
Authors: Getman H. K. , Mykhaylenko Yu. V. , Arpul S. V.
Published: June 2023

The procedure allowing to determine the optimum values of main external parameters of a locomotive for driving trains with the given train set and technical speed of motion is presented.
THE EVALUATING METHOD OF THE CONTINUATION RELIABILITY OF THE CONSTRUCTION LIFE OF RAILWAY TRANSPORT OF THE CHERNOBYL NPP
Authors: Donchenko A. V. , Khudiienko V. A. , Sheleiko T. V.
Published: June 2023

A methodical approach to the reliability estimation and service life prolongation of the railway carrier vehicle design, included into the bulk container wagon TK-8, and intended for transportation of exhausted nuclear fuel by rail tracks of the alienation zone is described. The results of work performed and the analysis of real operation conditions are presented.
METHODS AND MEANS OF IMPROVING RESOURCE OF THE TRIBOCOUPLING
Authors: Makarenko M. H.
Published: June 2023

The opportunity of increasing the resource of parts of tribosystems of machines and mechanisms by the method of wear autocompensation with the use of external energy source for formation and transfer of recovering material to the contact zone is considered.
THESTRENGTHASSESSMENTOFTHESHOCKINTERACTIONOFWHEELANDRAILATTHEJUNCTIONOFTWORAILS
Authors: Manashkin L. A. , Myamlyn S. V. , Prykhodko V. Y.
Published: June 2023

In the article some variants of a wheel passing a joint from rail to rail are considered and the forces occurring in this process are estimated. The related mathematical description of the wheel-rail shock interaction is proposed.
THE SPECIAL FEATURES OF THE STATE FINANCIAL POLICY
Authors: Vlasiuk V. Ye.
Published: June 2023

The article is devoted to the theoretical-and-methodical problems of research of conduction of the state financial policy peculiarities. The approaches to formation of the state profits are analyzed.
FEATURES OF THE INCENTIVES WORK AND MOTIVATIONAL PROCESSES SYSTEM IN THE RAILWAY INDUSTRY IN THE PERIOD OF UKRAINIAN ECONOMY TRANSFORMATION
Authors: Hetmanenko O. V.
Published: June 2023

Systems of the labour stimuli and realization of the motivation processes in the railway branch during the period of transformation of the economy ofUkraineare considered.
THE SYSTEM OF STANDARDS IMPROVING FOR PLANNING REPAIRS OF ROLLING STOCK AND TRACK
Authors: Zenchuk M. F.
Published: June 2023

As far as wear of the rolling stock and the track related to movement of a train on a section occurs during overcoming the resistance to movement of a train, it looks expedient to conduct the account in a database of performed mechanical work of forces of resistance to movement on each locomotive, car and track section, and depending on amount of this work to make their repairs and replacement.
PRODUCTIVE EMPLOYMENT AS THE BASIS OF THE MECHANISM OF ASSOCIATION AND THE ECONOMIC GROWTH AND SOCIAL DEVELOPMENT
Authors: Zova V. A.
Published: June 2023

The dependence of production employment efficiency and social and economic development is considered in this article.
ECONOMIC ASPECTS OF THE REGULATORY REQUIREMENTS IN THE DESIGN OF THE RECONSTRUCTION PLAN FOR TRANS-SHIPMENT POINTS
Authors: Korzhenevych I. P. , Todua T. H.
Published: June 2023

The influence of normative requirements on the cost indices of plan reorganization is considered.
INVESTMENT PARTNERSHIP BETWEEN THE STATE AND BUSINESS ON THE TRANSPORT: PATH AND PROBLEMS
Authors: Kudrytska N. V.
Published: June 2023

In the article the basic forms of state-private partnership as important instrument of upgrading the quality and competitiveness of transportation services in the world and European transport markets and inviting the investments in development of the transport-and-road complex ofUkraineare considered.
THE APPLICATION OF THE PRINCIPLES OF MARKETING AND LOGISTICS FOR THE IMPLEMENTATION OF THE NEW SERVICE ON PASSENGER RAILWAY TRANSPORT
Authors: Melnyk T. S. , Loboiko L. M. , Khrystofor O. V.
Published: June 2023

In the article the marketing research of conditions of introduction of a new service in the field of passenger service on the railway transport is presented, the organizational aspects of its providing on the base of application of logistic principles of management by stream processes are determined.
THE TAX SYSTEM REFORMING FOR SMALL BUSINESSES
Authors: Snachov M. P. , Verniuk A. V.
Published: June 2023

In the article some questions are considered concerning reformation of the taxation system of small businesses, the solution of them can improve the economy ofUkrainethrough the increase of quantity of small enterprises.
MANAGEMENT METHODS OF PRODUCTION EXPENDITURE
Authors: Shulha A. V. , Semeiko Ya. V.
Published: June 2023

The problem of search of the methods of management of production expeuditures has been examined and some ways of its solving have been proposed.
THE EFFECTIVENESS OF OUTSOURCING ON THE BELARUSIAN RAILWAY
Authors: Yachytska Ya. V.
Published: June 2023

Application of outsourcing as one of the Belarus Railway development strategies will allow to reduce expenses, to raise quality of given services, and also to reduce investments into non-profile kinds of activity.
INVESTIGATION OF THE INFLUENCE OF PARTICLE SIZE DISTRIBUTION OF SAND ON THE EFFECTIVENESS OF SAND PROVIDING SYSTEM LOCOMOTIVE
Authors: Buhaienko V. V. , Osenin Yu. I.
Published: June 2023

A process of interaction of the running-on air stream and the particle of an abrasive material on a way section from an exhaust outlet of sanding plant to a place of locomotive wheel/rail contact is considered. The mathematical model of movement of a particle is built. The trajectories of movement of particles of different sizes are calculated at various values of initial velocity and speed of a running-on air stream. Recommendations for choice of granulometric composition of the used abrasive material are given.
THE METHOD OF RELIABILITY ESTIMATION OF THE AUTOMATED CONTROL SYSTEM FUNCTIONING OF TRACTION POWER SUPPLY OF ELECTRIC TRANSPORT
Authors: Matusevych O. O.
Published: June 2023

The author proposed the examination method for estimating the reliability of functioning a system of automated control of traction electric supply systems for electric transport in order to organize the work with specialists-experts and to treat with experts’ opinions. This method enables us to make a decision about planning and taking the examination and forming the group of experts to conduct the results analysis and prepare the conclusions for people who make the decision on improving the reliability of a system of automated control of traction electric supply systems.
THE COSTS ASSOCIATED WITH THE RESISTANCE MOVEMENT FROM TRACK
Authors: Lipovskyi R. S. , Umanov M. I. , Gubar O. V. , Chernyshova O. S.
Published: June 2023

The procedure of determination of expenses related to the resistance to movement due to the track is presented.
NUMERICAL MODELING OF THE RIVER POLLUTION
Authors: Biliaiev M. M. , Pokutneva L. V.
Published: June 2023

The 2D numerical model to simulate the pollutant dispersion in rivers is offered. The model is based on the equation of potential flow and the transport model. The results of numerical experiment are presented.
THE PROBLEMS OF MODELING AN EXPERT AND ANALYTICAL TASKS WITH TAKING INTO ACCOUNT WELL-SPECTRAL DATA AND FACTORS
Authors: Bandorina L. M. , Savchuk L. M. , Klymkovych T. O.
Published: June 2023

In the paper there are considered the theoretical aspects of realization for well-grounded transition from classic stochastic models and expert judgments to fuzzy-set descriptions at modeling of expert analytic systems.
BRAKING PRECISION, THE CAR NUMBER IN THE TRAILER AND THE HUMP''S PERFORMANCE
Authors: Zhuravel V. V.
Published: June 2023

A form of regression equations is determined, which adequately describe a correlation between the error of braking of cuts and the average speed of their collision on hump tracks, the average length of «window» and the average quantity of setting operations per processed wagon taking into account an influence of quantity of wagons in a cut.
THE PRODUCTIVITY OF WORKERS OF LOCOMOTIVE FACILITIES OF UKRZALIZNYTSIA
Authors: Romanko V. I. , Romanko O. V.
Published: June 2023

An analysis of the factors, which influence on the change of labour productivity of the Ukrainian locomotive workers, is presented.
THE MINIMALIZATION OF FILTER EQUIPMENT FOR TRACTION SUBSTATIONS USING BOOSTER CONVERTER
Authors: Goncharov Yu. P. , Zamaruev V. V. , Ivahno V. V. , Liubych R. I. , Panasenko N. V.
Published: June 2023

The structure of traction substation 3,2 kV DC power source is considered. It is shown that the output filter choke of traction substation with voltage added converter may be excluded. A dynamic model of voltage added converter is developed, its features, as an active filter, are described.
THE ELECTROSTATIC CHARACTERISTICS OF LINEAR INSULATORS FOR CONTACT NETWORKS OF RAILWAYS
Authors: Kim Ye. D. , Sychenko V. H. , Kalmykov V. L.
Published: June 2023

On the base of numeric investigations on mathematical models of stationary electric field the basic electric performances of insulating suspensions from porcelain and polymeric insulators for contact nets of alternating and direct current are compared.
THE RATIONALE FOR THE USE OF TWO-PHASE SWITCHES FOR THREE-PHASE CONNECTIONS OF DISTRIBUTIVE DEVICE 27.5 KV
Authors: Sheika Yu. Ya.
Published: June 2023

On the basis of materials of scientists of Moscow and Petersburg State Universities of C Ways and NIIEFAENERGO Ltd.» the author of this article with additions has considered a practical possibility of us bipolar switches on three-phase connections of distributive device 27,5 кV.
STUDY OF DEFORMATION PROCESSING OF A RUT WITH FASTENERS OF ARS-4 TYPE
Authors: Rybkin V. V. , Nastechek M. P. , Hubar O. V. , Andrieiev V. S.
Published: June 2023

In the given article the analysis of dynamic characteristics of the railway track with fastenings АРС-4 is presented.
THE DISTRIBUTION MODELING OF IMPURITIES IN THE ATMOSPHERE WITH TAKING INTO ACCOUNT OF TERRAIN
Authors: Mashyhina P. B.
Published: June 2023

The 2D numerical model to simulate the pollutant dispersion over complex terrain was proposed. The model is based on the equation of potential flow and the equation of admixture transfer. Results of the numerical experiment are presented.
THE PROBLEMS SOLUTION OF ELASTICITY THEORY WITH SEPARATE DETERMINATION OF THE PURE STRAIN AND VOLUMETRIC DEFORMATION
Authors: Badalakha I. K.
Published: June 2023

In the article it is proposed to divide the overall deformation of elastic medium on two independent components – pure and voluminous ones, which are subjected to different physical relationships and determined separately. A comparative analysis of the results obtained is given.
THE EMPLOYABILITY WHOLE WELDED STRUCTURES OF RAILWAY BRIDGES
Authors: Kyrian V. I. , Knysh V. V. , Lynnyk H. O.
Published: June 2023

In the work the operating experience and methods of increasing the reliability and durability of steel bridges are investigated.
ANALYTICAL DESCRIPTION OF THE CURVE CYCLIC LOAD OF CARBON STEEL
Authors: Vakulenko I. O.
Published: June 2023

In the article the research results of mathematical description of curve of cyclic loading of carbon steel are presented.
ASSESSMENT OF F HOUSING AVAILABILITY FOR THE POPULATION IN DNIPROPETROVSK REGION
Authors: Bozhanova V. Yu. , Razumova V. A.
Published: June 2023

In the article the main modern progress of the housing market trends are considered. The calculations of coefficient of housing price to income ratio for the population of Dnipropetrovs’k region are produced. The results of these calculations are analyzed too.
THE RESTRUCTURING OF UKRAINIAN RAILWAY TRANSPORT IN THE CONDITIONS OF THE WORLD FINANCIAL CRISIS
Authors: Bulhakova Yu. V. , Piatyhorets H. S.
Published: June 2023

The proposals to determine the optimal order of realization of restructuration of Ukrainian railway transport in conditions of the world financial crisis was elaborated in this article.