bluuebunny/crossref_metadata_2025 huggingface dataset:
Faktor Risiko Musculoskeletal Pain pada Pasien Chronic Myeloid Leukemia (CML) dengan Kemoterapi Nilotinib di RSUD Dr. Moewardi
Authors: Niruri Rasmaya , Pamungkasari Eti Poncorini , Rahmah Syifa Maulida
Published: July 2021

Chronic Myeloid Leukemia (CML) merupakan penyakit mieloproliferatif yang ditandai dengan peningkatan sel mieloid dan ditemukan adanya kromosom Philadelphia yang disebabkan karena adanya translokasi respirok gen BCR-ABL. Nilotinib adalah Tyrosine Kinase Inhibitor (TKI) yang disetujui untuk pengobatan pasien dewasa yang baru di diagnosis CML dalam fase kronis (CML-CP) dengan kromosom Philadelphia positif (Ph+) atau pasien Ph+ CML yang resisten atau tidak toleran terhadap imatinib dalam fase kronis (CP) atau fase dipercepat (AP). Pada beberapa studi menunjukkan bahwa nilotinib berkaitan dengan munculnya efek samping obat. Salah satu efek samping obat yang terjadi pada penggunaan nilotinib yaitu musculoskeletal pain. Penelitian ini bertujuan untuk mengetahui frekuensi terjadinya musculoskeletal pain dan menganalisis pengaruh faktor usia, Indeks Masa Tubuh (IMT), dan riwayat Diabetes Mellitus (DM) pada pasien CML dengan kemoterapi nilotinib di RSUD Dr. Moewardi. Penelitian dilakukan sebagai studi observasional dengan desain cross sectional pada 35 subyek pasien CML dengan kemoterapi nilotinib pada bulan Januari 2016 – Maret 2019. Evaluasi dilakukan selama 1 tahun setelah subyek mendapatkan kemoterapi nilotinib dengan menggunakan rekam medis dan lembar pengumpul data.Hasil penelitian ini menunjukkan bahwa 13 pasien (37,1%) mengalami musculoskeletal pain. Hasil evaluasi dengan Algoritma Naranjo yaitu 7 pasien masuk dalam kategori possible dan 6 pasien dalam kategori probable. Indeks Masa Tubuh (IMT) berpengaruh secara signifikan terhadap terjadinya musculoskeletal pain dengan nilai p sebesar 0,041, nilai Odds Ratio sebesar 7, dan Interval Kepercayaan 95% sebesar 1,09 – 45,16. Sedangkan, faktor usia dan riwayat DM tidak berpengaruh secara signifikan terhadap terjadinya musculoskeletal pain.
ANALISIS PENGETAHUAN TATA RIAS WAJAH SEHARI-HARI DAN PERILAKU PENGGUNAAN KOSMETIKA
Authors: Gautama Chika
Published: July 2021

CHIKA ERFIANDI GAUTAMA. Analisis Pengetahuan Tata Rias Wajah Sehari-hari dan Perilaku Penggunaan Kosmetika (Studi pada PNS Wanita di Kementriaan Pendidikan dan Kebudayaan). Jakarta. Program Studi Diploma Tiga Tata Rias, Fakultas Teknik, Universitas Negri Jakarta, 2020.

Penelitian ini bertujuan untuk mendeskripsikan mengenai gambaran pengetahuan tata rias wajah dan perilaku penggunaan kosmetika di kalangan Pegawai Negeri Sipil (PNS) wanita di KEMENDIKBUD. Objek penelitian ini adalah Pegawai Negeri Sipil (PNS) yaitu sebanyak 25 orang. Penelitian ini dibuat menggunakan metode deskriptif kuantitatif dengan menyebar kuesioner kepada Pegawai Negeri Sipil (PNS) wanita yang bekerja di KEMENDIKBUD. Berdasarkan kajian teoritis dan pengumpulan data yang dilakukan dalam penelitian ini menghasilkan nilai pengetahuan tata rias sebesar 92.5% dan perilaku penggunaan kosmetika sebesar 86.04%. Maka dapat disimpulkan bahwa pengetahuan tata rias serta perilaku penggunaan kosmetika di kalangan PNS wanita KEMENDIKBUD termasuk dalam kategori sangat baik. Hasil ini dapat diperoleh karena didukung oleh faktor-faktor seperti faktor pendidikan, faktor pekerjaan, dan faktor pengalaman.
Incorporating Qur’anic Interpretation Into Course Materials Of English For Business: A Students' Perspective
Authors: Setyaningrum Anisah
Published: July 2021

This paper aims at investigating the students’ perspectives toward incorporating qur’anic interpretation into course materials of English for Business. This study is a qualitative survey. The subject of the study were 20 students of English subject in Sharia Business Management Study Program, Islamic Economic and Business Faculty, State Islamic Institute of Kudus, Central Java, Indonesia. The data were collected by spreading the questionnaire to the students and asked them to fill it. Then, the Likert Scale was implemented in analyzing the data. Result of this study shows that students have positive perspectives toward incorporating qur’anic interpretation into course materials of English for Business.
DOES SPIRIT OF NATIONALISM STILL EXIST THROUGH GUIDANCE & COUNSELING SERVICE ? (The Fieldtrip Study Analysis at (SIKL) Indonesian School Students of Kuala Lumpur)
Authors: Nisa’ Siti Liana Nurun , Azmi Khilman Rofi'
Published: July 2021

Does Spirit Of Nationalism Still Exist Through Guidance & Counseling Service? (The Fieldtrip Study Analysis at (SIKL) Indonesian School Students of Kuala Lumpur). This study aims to describe the spirit of nationalism in guidance and counseling services (analytical studies at the Indonesian School of Kuala Lumpur (SIKL). This research uses a field visit study method. Where field study visits are conducted online via zoom. The approach used is qualitative. This approach is descriptive based on observations in the form of words or observed behavior. The data sources are diverse, such as observation notes, history, and interview notes. While this article is the source of the data from interviews. The research data collected was then analyzed using a descriptive analysis approach. The results of the study indicate that BK teachers have an important role in helping the success of character education. In Malaysia, there are many Indonesians living there. So, the Kuala Lumpur Indonesian School is presented as an effort for the Indonesian people to instill in every citizen everywhere to be able to experience an integrated education, namely the national education system. SIKL is an overseas Indonesian school that is committed to educating students and promoting Indonesian culture in the global community. There are several forms of activities that support the character of nationalism, namely by holding extracurricular arts, expression stages, scouts, and cultural diplomacy. From these activities, SIKL students became students with strong nationalist characters and became agents of promoters of Indonesian culture in Malaysia.
Keywords: Guidance and Counseling; Spirit Nationalism; Kuala Lumpur Indonesian School Students
Implementasi Manajemen Bimbingan dan Konseling di MTs NU TBS Kudus
Authors: Bayan Muhammad Aqib Khusnul
Published: July 2021

Implementation of Guidance and Counseling Management at MTs NU TBS Kudus. This study aims to determine the implementation of guidance and counseling management at MTs TBS Kudus. The method in this study uses a qualitative descriptive method with a case study approach at MTs TBS Kudus. The collected data was then analyzed by the data analysis technique used in this study is a descriptive analysis in the field of the Miles and Huberman model. The results showed that the implementation of the management of counseling guidance at MTs TBS Kudus has been going well. The program planning stage is by analyzing student needs and problems, analyzing school conditions, determining goals, understanding and determining materials, determining time and place, determining facilities and planning budgets. The organizing stage is carried out by selecting a competent counselor. The stage of implementing guidance and counseling at MTs TBS Kudus by carrying out counseling services in accordance with SOP equipped with supporting activities. The evaluation stage of the BK program is by evaluating programs and then improving them again.
Keywords: Implementation, Counseling Guidance Management, MTs TBS Kudus
Compression of the Median Nerve and Ulnar Nerve's Deep Palmar Branch by a Ganglion Cyst in the Carpal Tunnel
Authors: Yanagisawa Sho , Takagi Takehiko , Kodama Mitsuhiko , Kobayashi Yuka , Watanabe Masahiko
Published: July 2021

Case:

A 39-year-old woman presented with a ganglion cyst in the carpal tunnel simultaneously compressing the right median nerve and the deep palmar branch of the ulnar nerve. During surgery, the soft tissue was exposed under the median nerve and on the deep palmar branch of the ulnar nerve running transversely in the deep area of the carpal tunnel.

Conclusion:

Simultaneous compression of the median nerve and deep palmar branch of the ulnar nerve is extremely rare; however, such a pathoanatomical relationship must be considered while examining a patient because these nerves are located close to each other.
Intravascular Mesenchymal Chondrosarcoma of the Femoral Vein
Authors: Sabharwal Samir , Fayad Laura M. , McCarthy Edward F. , Morris Carol D.
Published: July 2021

Case:

A 30-year-old man presented with progressive lower right extremity pain and swelling, initially diagnosed as a deep venous thrombosis. He returned 18 months later after 2 episodes of gross hemoptysis, with chest computed tomography angiography findings concerning for tumor thrombus in the left pulmonary artery. Subsequent advanced imaging showed a lesion arising from his right femoral vein, which open biopsy revealed to be a primary intravascular mesenchymal chondrosarcoma. He underwent medical therapy, with improvement of pain and swelling and successful return to work.

Conclusion:

Mesenchymal chondrosarcoma is a rare pathology, and its intravascular origin makes this case extraordinarily uncommon.
Posterior Wall Acetabulum Fracture with a Persistent Sciatic Artery
Authors: Chang Gerard , Chip Routt Milton L. , Warner Stephen
Published: July 2021

Case:

We report the case of a patient who sustained a left posterior wall acetabular fracture with an ipsilateral persistent sciatic artery (PSA). The PSA was diagnosed preoperatively on lower extremity computed tomography angiogram. He was treated with open reduction internal fixation through a Kocher-Langenbeck approach. The PSA and sciatic nerve were identified and protected throughout the case. There were no neurovascular complications.

Conclusion:

PSA in the setting of posterior wall acetabulum fractures has not been reported previously. Orthopaedic surgeons who treat these injuries should be aware of PSA anatomic variants so that they can be identified and protected during surgery.
Rancang Bangun Mekanika Smart Box Untuk Aquarium Ikan Hias Berbasis Arduino
Authors: Gundara Gugun , Risnandar Rifqi
Published: July 2021

Penelitian ini dilaksanakan dengan tujuan merancang alat yang dapat memberi pakan ikan otomatis, monitoring suhu dan kadar gas amonia pada aquarium ikan hias dengan menggunakan mikrokontroller arduino. Dengan menggunakan motor servo untuk membuka dan menutup katup tempat pakan ikan, Real Time Clock sebagai pengatur waktu dan jadwal pemberian pakan, sensor DS18b20 untuk memonitoring suhu yang ada pada aquarium, serta sensor MQ-135 untuk mengukur kadar gas amonia pada aquarium.Pemberian pakan ikan disesuaikan dengan jumlah berat total ikan yang ada pada aquarium, sehingga untuk menentukan jumlah pakan dilakukan dengan memberikan jeda pada servo. Suhu yang baik untuk aquarium adalah berkisar 29ºC, sehingga untuk mendapatkan suhu yang sesuai pemelihara dapat melakukan penyesuaian dengan menambahkan air hangat atau air dingin agar suhu yang ada pada aquarium dapat sesuai dengan yang dibutuhkan. Kadar gas amonia pada aquarium yang baik adalah berkisar antara 0,2 - 0,5 ppm, agar kadar gas amonia pada aquarium tidak terlalu tinggi dan sesuai yang dibutuhkan dapat dilakukan dengan cara membersihkan aquarium secara berkala dan mengganti air yang ada pada aquarium.
Degrading Permafrost Mapped with Electrical Resistivity Tomography, Airborne Imagery and LiDAR, and Seasonal Thaw Measurements
Authors: Douglas Thomas A. , Hiemstra Christopher A. , Saari Stephanie P. , Bjella Kevin L. , Campbell Seth W. , Jorgenson M. Torre , Brown Dana R. N. , Liljedahl Anna K.
Published: July 2021

Accurate identification of the relationships between permafrost extent and landscape patterns helps develop airborne geophysical or remote sensing tools to map permafrost in remote locations or across large areas. These tools are particularly applicable in discontinuous permafrost where climate warming or disturbances such as human development or fire can lead to rapid permafrost degradation. We linked field-based geophysical, point-scale, and imagery surveying measurements to map permafrost at five fire scars on the Tanana Flats in central Alaska. Ground-based elevation surveys, seasonal thaw-depth profiles, and electrical resistivity tomography (ERT) measurements were combined with airborne imagery and light detection and ranging (LiDAR) to identify relationships between permafrost geomorphology and elapsed time since fire disturbance. ERT was a robust technique for mapping the presence or absence of permafrost because of the marked difference in resistivity values for frozen versus unfrozen material. There was no clear relationship between elapsed time since fire and permafrost extent at our sites. The transition zone boundaries between permafrost soils and unfrozen soils in the collapse-scar bogs at our sites had complex and unpredictable morphologies, suggesting attempts to quantify the presence or absence of permafrost using aerial measurements alone could lead to incomplete results. The results from our study indicated limitations in being able to apply airborne surveying measurements at the landscape scale toward accurately estimating permafrost extent.
Prevalence of Intestinal Parasites and Associated Risk Factors in Chepang Community of Saktikhor Area, Chitwan, Nepal
Authors:   Central Department of Zoology, Tribhuvan University, Kathmandu, Nepal., Adhikari Srijana
Published: July 2021

Abstract: Objective: Pathogenic species of protozoa and helminth cause intestinal parasitosis, which continues to be a significant community well-being issue in many regions of the world, especially in pastoral regions of developing countries like Nepal. The study focused on determining the prevalence of intestinal parasitic infections and the associated risk factors among the people of the Chepang community of the Saktikhor area in the Chitwan district. Materials and Methods: A transversal study was conducted between May 2017 and October 2017, with a total of 125 participants. The fecal samples were examined using a wet media (saline media, iodine preparation), concentration and sucrose flotation method. The association between risk factors and parasitic prevalence was evaluated using the Pearson’s chi-square test. Results: The general prevalence of intestinal parasite infection was 52%. Infections with soil-borne helminth were more common than those with cestodes and protozoa. Common intestinal parasites included Ascaris lumbricoides (69.23%), Trichuris trichiura (9.23%), Hookworm (7.69%), Strongyloides stercoralis (4.62%), Hymenolepis nana (6.15%), Taenia sp. (6.15%), and Entamoeba coli (9.23%). High prevalence of infection was observed among male (53.96% ) participants and those aged over 20 years (69.44%). Pearson's chi-square test revealed a substantial relationship between prevalence of parasite and age group (P=0.0452), hand washing material (P<0.001) and preference for defecation site (P<0.001). Conclusion: Hence, a heavy occurrence of intestinal parasites within the Chepang community is particularly evident. There is a need for increased emphasis on intrusion, which can be achieved by improving personal hygiene and sanitation of participants and constructing proper sanitary toilets to prevent the spread of parasitic infections. Keywords: IPIs, Helminth, Cestode, Protozoan, HMP, NTDs, Community, Prevalence.
Pediatric Chronic Myeloid Leukemia with Megakaryocytic Blast Crisis as Initial Presentation: Case Report and Review of Literature
Authors:   Department of Clinical Hematology, National Institute of Blood Disease & Bone Marrow Transplantation, Karachi, Pakistan., Iqbal Tuba , Younus Amber ,   Department of Clinical Hematology, National Institute of Blood Disease & Bone Marrow Transplantation, Karachi, Pakistan., Zaidi Uzma ,   Department of Clinical Hematology, National Institute of Blood Disease & Bone Marrow Transplantation, Karachi, Pakistan., Hassan Jawad ,   Department of Diagnostic Hematology, National Institute of Blood Disease & Bone Marrow Transplantation, Karachi, Pakistan., Shamsi Tahir Sultan ,   Department of Clinical Hematology, National Institute of Blood Disease & Bone Marrow Transplantation, Karachi, Pakistan.
Published: July 2021

Abstract: Background: Pediatric Chronic Myeloid Leukemia (CML) is a rare entity accounting for 2-3% of pediatric malignancies. CML rarely presents as Blast Crisis (BC) at the time of diagnosis, and megakaryocytic blast crisis is even rarer. Case Presentation: We herein, report a case of a young female, 10-year-old who presented with anemia, leukocytosis and massive splenomegaly. Clinical features, peripheral film and bone marrow findings were consistent with CML in megakaryocytic blast crisis. Bone marrow cytogenetic analysis revealed karyotype of 46, XX, t(9:22)(q34;q11.2) in 20 metaphases and BCR-ABL P210 by PCR was detected with transcript level of 83%, which further confirmed our diagnosis. Conclusion: De novo presentation of chronic myeloid leukemia with megakaryocytic blast crisis is rarely observed in pediatric population with very few cases published till now. We are presenting this case because of its rarity, likelihood of misdiagnosis as AML (M7) and poor prognosis, if not treated precisely. Keywords: Chronic Myeloid Leukemia (CML), Acute Myeloid Leukemia (AML), Blast Crisis (BC), Acute Megakaryocytic Leukemia (AMKL), Chronic Phase (CP), Accelerated Phase (AP), Tyrosine Kinase Inhibitor (TKI).
A Case Report: An Overweight Patient with High Dose Insulin Usage
Authors:   Department of Internal Medicine, Abant Izzet Baysal (AIB) University Hospital, Bolu, Turkey., Atak Burcin Meryem , Tel Mustafa Ramiz ,   Department of Internal Medicine, Abant Izzet Baysal (AIB) University Hospital, Bolu, Turkey.
Published: July 2021

Abstract: Insulin is vital for patients with type 1 diabetes and useful for certain patients with type 2 diabetes [1]. In this article we aim to explain a case wrongly using high dosage insulin. A 68-year-old female patient with known 10 years of type 2 diabetes mellitus and hypertension came to our outpatient clinic because her blood glucose levels were high at home. She was using perindopril 10 mg, metformin and insulin. Since the patient did not want to make multiple injections her previous doctor has changed her therapy from glargine u300 1x50 units and insulin aspart 3x30 units to a mixed insulin; insulin degludec + insulin aspart, as 2x 40 units per day. However, the patient did not understand the change of treatment and made the combination of insulin glargine u300 1x50 units and insulin degludec + insulin aspart two times a day as 30 units. She was using this therapy more than two months. Diabetes and complications of diabetes is a challenging healthcare problem. Especially patients’ education is as important as the drug therapy [2, 3]. Among serious side-effects of insulin therapy are overdose, resulting in severe hypoglycemia, causing seizures, coma and even death [1]. Patients must be well educated about the risks of using high doses of insulin. Keywords: High dose insulin, Obesity, Type 2 diabetes mellitus, Patient education, Hypoglycemia, Insulin overdose
The qualitative and quantitative classification of modern clastic marginal-marine depositional systems, Trinidad
Authors: Khan Saeed , Vincent Hasley , Wilson Brent
Published: July 2021

Trinidad's modern coastal depositional systems are for the first time documented by (traditional) descriptive and (modern) semiquantitative and quantitative classification methods. The processes controlling the morphology and distribution of these systems are also investigated. Google Earth™ satellite images, together with published basinal processes data (e.g., significant wave height, surface littoral currents, and tidal cyclicity) are used to describe system morphology, map depositional elements, and to determine the processes responsible for system distribution, respectively.

Coastal depositional systems along Trinidad's east, south, and west coasts comprise deltas, estuaries, tidal-inlet complexes, strandplains, and tidal flats. Their distribution is controlled by the wave regime, although they are also influenced by tidal and fluvial processes. The wave regime changes from wave-dominated along the open east coast, to mixed-energy wave-dominated along the semi-sheltered south coast, and to mixed-energy tide-dominated along the sheltered west coast. Distribution of depositional systems related to this regime are such that the wave-dominated east coast sees the development of wave-dominated estuaries. The south coast has a series of wave-dominated, tide- and river-influenced deltas. The sheltered west coast is the most morphologically diverse with river- and wave-dominated deltas, strandplains, and tidal flats.

The application of semiquantitative and quantitative classification methods on modern systems has showed their competence in classifying mixed-influence systems from their morphology and sedimentary record. Quantitative classification using depositional elements lends an appreciation to the morphological signatures of mixed-influence systems. Quantitative classification for sedimentary sections gives an appreciation of the preservation of mixed-influence physical processes. The combination of both allows the correlation of the impact of physical properties on morphology and sedimentary record (i.e., possible disparities between morphology and processes). The combination of semiquantitative and quantitative methods may also hold the key to unlocking the mixed-processes classification of depositional elements.
ЭВОЛЮЦИЯ УСЛУГ ПРОМЫШЛЕННОГО ХАРАКТЕРА В РЕСПУБЛИКЕ БЕЛАРУСЬ В 1995−2015 ГГ.
Authors: МЕЛЕШКО Ю.
Published: July 2021

С целью изучения развития услуг промышленного характера в Республике Беларусь в 1995-2015 гг. и выявления основных зависимостей между развитием промышленного комплекса и сферы услуг в статье был проведен статистический анализ изменения структуры ВВП Беларуси, структуры занятости, а также качественных и количественных изменений, происходящих как в сфере производства, так и в сфере услуг за рассматриваемый период.
КОЛИЧЕСТВЕННАЯ МЕТОДИКА ОЦЕНКИ УРОВНЯ ЭКОНОМИЧЕСКОЙ УСТОЙЧИВОСТИ ПРЕДПРИЯТИЙ ДЕРЕВООБРАБАТЫВАЮЩЕЙ ПРОМЫШЛЕННОСТИ РЕСПУБЛИКИ БЕЛАРУСЬ
Authors: КОБРИНЕЦ К. , ХАЦКЕВИЧ Г.
Published: July 2021

В статье изложены основные теоретические подходы к определению сущности категории «экономической устойчивости», рассматривается методика количественного определения устойчивости экономических систем и отдельных хозяйственных систем.
ЭФФЕКТИВНОСТЬ ПРИМЕНЕНИЯ ЛОГИСТИЧЕСКОГО ПОДХОДА ПРИ СТРОИТЕЛЬСТВЕ ЭНЕРГЕТИЧЕСКИХ ОБЪЕКТОВ
Authors: МАНЦЕРОВА Т. , ЧИЖ Е.
Published: July 2021

Энергетика имеет специфические особенности, отличающие ее от других видов экономической деятельности. Это, прежде всего, технологические особенности. Важное значение имеют и внутриотраслевые особенности энергетики такие как, высокая концентрация производства в пределах одного предприятия и одновременно рассредоточение энергетических предприятий с единым технологическим процессом на больших территориях; жесткая зависимость режима работы энергетических предприятий друг от друга; высокая фондоемкость, длительные сроки службы энергетических предприятий и т.п. Основными признаками, которые определяют энергетику, как монополию, являются большая капиталоемкость; наличие тесной и непосредственной связи с потребителем; производство продукции в конкретных географических точках; обеспечение жизнеспособности общества; неэластичный спрос на товар (энергию).
УПРАВЛЕНИЕ РИСКАМИ С УЧЕТОМ ТЕХНОЛОГИЧЕСКИХ ОСОБЕННОСТЕЙ ПРОИЗВОДСТВА ЭНЕРГИИ
Authors: МАНЦЕРОВА Т. , ТЫМУЛЬ Е.
Published: July 2021

В статье рассмотрено понятие оценки риска и ее математическая модель. Уточнена специфика рисков в зависимости от стадии технологического процесса производства энергии. Предложен авторский подход к возможному учету и анализу рисков в энергетике в условиях создания рынка энергии. Уточнена необходимость создания специальной структуры, в функции которой входит оценка и анализ риска
ТЕОРЕТИКО-МЕТОДОЛОГИЧЕСКИЕ ОСНОВЫ ИССЛЕДОВАНИЯ СОЦИАЛЬНОГО КАПИТАЛА КАК ПОЛИТИКО-ЭКОНОМИЧЕСКОГО ФЕНОМЕНА
Authors: СОЛОДОВНИКОВ С.
Published: July 2021

На основе раскрытия теоретико-методологических основ исследования социального капитала как политико-экономического феномена выяснено, что специфическим свойством социального капитала
является то, что его совокупное количество в обществе не является суммой «социальных капиталов» всех его субъектов. Показаны методологические основы применения институционального подхода при
исследовании социального капитала. Раскрыта специфика социального капитала в глобализирующемся обществе.
Lipidomic analysis of archival pathology specimen identifies altered lipid signatures in ovarian clear cell carcinoma
Authors: Mir Sartaj Ahmad , Wong Soon Boon Justin , Narasimhan Kothandaraman , Esther Chua Wee Ling , Ji Shanshan , Burla Bo , Wenk Markus R. , Tan David S.P. , Bendt Anne K.
Published: July 2021

Cancer metabolism is associated with enhanced lipogenesis required for rapid growth and proliferation. However, the magnitude of dysregulation of diverse lipid species mostly remains to be characterized, particularly in rare cancers such as ovarian clear cell carcinoma (OCCC). Here we implemented a robust sample preparation workflow together with targeted LC-MS/MS to identify the lipidomic changes in formalin-fixed paraffin-embedded specimen from OCCC as compared to uninvolved contralateral ovarian tissue. We quantitated 342 lipid species representing 28 lipid classes. We observed differential regulation of diverse lipid species belonging to several glycerophospholipid classes and trihexosylceramide. A number of unsaturated lipid species were increased whereas saturated lipid showed a decrease in OCCC as compared to the controls. We also carried out total fatty acid analysis and observed increase in the levels of several unsaturated fatty acids with concomitant increase in the index of stearoyl-CoA desaturase (SCD) in OCCC. We confirmed the upregulation of SCD, the rate-limiting enzyme for the synthesis of monounsaturated fatty acids, by immunohistochemistry (IHC) assays. Hence, by carrying out mass spectrometry analysis of archival tissue samples, we were able to provide novel insights into the lipidomic alterations of OCCC.
Psychosocial factors affecting end-stage kidney disease patients and the impact of social worker
Authors: Hansen Micaela S , Tesfaye Wubshet Hailu , Sewlal Beena , Mehta Bharati , Sud Kamal , Kairaitis Lukas , Tarafdar Surjit , Chau Katrina , Zaidi Syed Tabish , Castelino Ronald
Published: July 2021

Background
End-stage kidney disease (ESKD) incidence has been increasing over time, contributing significantly to morbidity and early mortality. However, there is limited data examining the psychosocial factors affecting people with ESKD and how the social worker fits within the multidisciplinary CKD care. This integrative systematic review aims to summarise the existing evidence on psychosocial determinants of outcomes in ESKD and the role of renal social worker.
Method:
Literature search was conducted using PubMed and MEDLINE targeting articles published from database inception until May 2021. This systematic review was performed in compliance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The Joanna Briggs Institute tools were employed to assess the quality of included studies.
Results
Of the 397 citations, 13 studies applicable to 1465 patients met the inclusion criteria. The studies were of cross-sectional, experimental, and exploratory qualitative design in nature. The findings of the studies were summarised into three major themes — psychosocial factors, role of the renal social worker, and impact of the renal social worker. The studies demonstrated that concerns related to adjustment, death and dying, family and social functioning, and loss were common amongst participants of the included studies indicating the need for a social worker. Three studies explored the impact of social workers in ESKD, revealing people who receive support from social workers had an improved quality of life, lower depression scores, reduced hospitalisations, and emergency room visits.
Conclusion
This review reports the multitude of physical and psychological stressors that patients with ESRD face, highlights the positive role renal social workers can play in improving the psychosocial stressors in this patient group and the need for large-scale randomised trials to understand the role of renal social workers as part of a multidisciplinary care.
Puzzling and powering in the city: two case studies on collaborative research
Authors: Duiveman Robert
Published: July 2021

Cities are turning to urban living labs and research consortia to co-create knowledge that can better enable them to address pervasive policy problems. Collaborations within such practices help researchers, officials and local stakeholders find new ways of dealing with urban issues and developing new relations with one another. Interestingly, success in the latter is often closely related to accomplishing the former. Besides of analysing this phenomenon in terms of learning—as is common—this paper also delves into the power dynamics involved in collaborative knowledge development. This perspective contributes to a better understanding of how puzzling and powering are simultaneously involved in making research relevant to policy-making. By presenting two collaborative research consortia in the Netherlands, we demonstrate how developing knowledge involves both re-structuring problems and the urban practices involved in governing such problems. Collaborative research practices are predominantly concerned with learning as long as restructuring the problem leads to research findings that are meaningful to all actors. Power becomes manifest when one actor insists on restructuring (often reproducing) problems in a manner judged unacceptable by others. Analysis of two case studies will show how the familiar three faces of power express themselves in collaborative knowledge development. It is recommended that these new practices also require methods for better orchestrating power besides a methodology for successful structuring learning through collaborative research practices.
Behavior of the Central Intensity of Generalized Humbert-Gaussian Beams Against the Atmospheric Turbulence
Authors: Nossir Naima , Dalil-Essakali Latifa , Belafhal Abdelmajid
Published: July 2021

Based on the generalized Huygens-Fresnel integral in the paraxial approximation and on the Rytov theory, the analytical expression of the axial intensity distribution for the Generalized Humbert-Gaussian beams (GHGBs) propagating through a turbulent atmosphere is derived in this work. The results for the special cases of GHGBs are deduced from our study and illustrated numerically. The influence of the turbulent strength and the incident beam parameters on the propagation of these beams in the atmospheric turbulence is investigated and discussed in detail.
Evaluation of Antioxidant Potential and Efficacy of Terpenoid Rich Fraction of Phyllanthus Amarus (Schum and Thonn) Whole Plant in the Amelioration of High Salt Diet Induced Obesity.
Authors: Fasan Tope Israel , Olorunnisola Olubukola Sinbad , Adetutu Adewale , Ajilore Bamidele Stephen
Published: July 2021

Background

It’s overwhelmingly accounted that there is high prevalence of high salt diet related adiposity and metabolic antioxidant infringement worldwide. The present study thus aimed to establish the folkloric use of Phyllantus amarus by traditional practitioners and compliment orthodox medicine in the management of high salt diet driven adiposity and vehemently associated with pro-oxidant cascades. The principal focus was to fractionate, evaluate the lethal dose of terpenoid rich concentrate of the Phyllanthus amarus (Schum and Thonn) whole plant using up and down method and investigate the in vivo antioxidant potential and antiobesity of the rich concentrate in healthy adult male Sprague-Dawley rats fed with 8% high salt diet for 8weeks.
Results

The results of the study revealed that there was a significant (p < 0.05) weight gained (54.50%) in the experimental group fed with a high salt diet when compared with rats fed with normal chow (51.19%). However, rats co-administered with High salt diet (8%) and terpenoid rich fraction (TRF) of the whole plant (75, 100, 150mg/kg/body weight), had a significant weight recuperation in dose-dependent manner (50.86%, 48.13%, 43.25%) in comparism to groups fed with normal rat chow (51.19%), with corresponding significant (p < 0.05) and dose-dependent decrease in the concentration of oxidative marker product malondialdehyde (MDA) (9.38 ± 0.22, 7.92 ± 0.11, 6.03 ± 0.18) and dose-dependent metabolic improvement of both the non-enzymatic reduced Glutathione (GSH) (40.15 ± 0.04, 46.21 ± 0.01, 51.22 ± 0.03) and enzymatic catalase (25.22 ± 0.01, 30.31 ± 0.05, 38.52 ± 0.03) activities.
Conclusion

Therefore, the terpenoid rich fraction of Phyllanthus amarus (Schum and Thonn) whole plant could therefore be applied as a recuperative agent against obesity and prooxidant proliferation in high salt diet related pathologies.
Oceaniglobus Trochenteri sp. nov., Isolated from the Gut Microflora of top Shell (Trochus Maculatus Linnaeus).
Authors: Chen Zhuo , Yun Shuai-ting , Zhang Ming-jing , Yin Rui , Zhou Yan-Xia
Published: July 2021

A Gram-stain negative, non-flagellated, beige-pigmented, circular, catalase-positive, oxidase-positive bacterium, designated G4T, was isolated from gut microflora of top shell (Trochus maculatus Linnaeus) collected from Diwanggong market, Weihai, PR China. The novel isolate was able to grow at 4–42°C (optimum 25–33°C), pH 7.0–9.0 (optimum 6.5–7.0) and with 0.0–11.0% NaCl (optimum 2.0–3.0%, w/v). Analysis of 16S rRNA gene sequence revealed that strain G4T shared the highest 16S rRNA gene sequence similarities with Oceaniglobus YLY08T (96.6%), followed by Oceaniglobus indicus 1-19bT (95.3%). The genome of strain G4T, with 32 assembled contigs, was 4.5 Mb long with a G + C content of 65.3 mol%. DNA–DNA hybridization values of the isolate against the closely related type strains were far below the 70% limit for species delineation. The average amino acid identity, average nucleotide identity and digital DNA-DNA genome hybridization relatedness between strain G4T and the closely related members of the genus Oceaniglobus, Oceaniglobus indicus1-19bT and Oceaniglobus ichthyenteri YLY08T were 71.3, 76.4 and 20.0%, and 75.0, 76.3 and 19.4%. The major cellular fatty acid was summed feature 8 (C18:1ω7c and/or C18:1ω6c). The sole respiratory quinone detected was Q-10. The polar lipid profile consisted of diphosphatidylglycerol, phosphatidylcholine, phosphatidylethanolamine, phosphatidylglycerol and phosphatidyldimethylethanolamine. The results of phenotypical, phylogenetic and biochemical analyses indicated that strain G4T represents a novel species in genus Oceaniglobus within the family Rhodobacteraceae, for which the name Oceaniglobus trochenteri sp. nov. is proposed. The type strain is G4T (= MCCC 1K04356T = KCTC 82506T).
miR-133a-3p Functions as a Tumor Suppressor in Colorectal Cancer by Targeting PFKFB3
Authors: Zhou Yanjie , Jiang Lu , Cai Yuanjun , Tang Wendong , Wang Ke
Published: July 2021

Background

Recent studies reveal that PFKFB3 plays an important role in tumorigenesis and tumor progression. Our study aims to identify an novel microRNA which can suppress the expression of PFKFB3 and to provide a potential target for tumor therapy.
Methods

Bioinformatics methods were implemented to explore the expression and clinical significance of PFKFB3 and miR-133a-3p in colorectal cancer (CRC). qRT-PCR was performed to detect PFKFB3, miR-133a-3p, KI67 and MMP9 mRNA expression, while western bot was carried out for the detection of protein expression of PFKFB3, miR-133a-3p, KI67 and MMP9. Bioinformatics analysis was used to predict the binding sites of miR-133a-3p on PFKFB3 3’UTR, while dual-luciferase assay was conducted to validate their binding relationship. CCK-8 assay, KI67 detection, Transwell assay and MMP9 detection were employed to measure CRC cell proliferative and invasive abilities.
Results

PFKFB3 expression is up-regulated in colorectal cancer, and is significantly associated with poor prognosis. Silencing PFKFB3 could inhibit the proliferation and invasion of colorectal cancer cells. miR-133a-3p is down regulated in colorectal cancer, which has diagnostic value for colorectal cancer. Dual luciferase assay confirmed that PFKFB3 was the direct acting site of miR-133a-3p. Overexpression of miR-133a-3p could significantly reduce the expression of PFKFB3 and inhibit the effect of PFKFB3 on the proliferation and invasion of colorectal cancer cells.
Conclusions

Our study suggested that miR-133a-3p functions as a novel tumor suppressor in colorectal cancer by targeting PFKFB3.
A global bibliometric and visualized analysis in the state of Pseudomonas aeruginosa efflux pump research
Authors: Zhang Ruiqin , Wang Siyang , Ren Jian , Li Zhen , Wang Hongxia , Zhi Tingting , Zhu Yuanyuan , Wang Yanhui , yao zhiqing , Zhang Huizi , DAUN jinju
Published: July 2021

OBJECTIVE. This study was designed with the goal of surveying the current status of the Pseudomonas aeruginosa efflux pump research field in an effort to explore current and future trends in this clinically relevant research area. METHODS. Bibliometric and visual analyses were used to conduct a global survey of the current status of Pseudomonas aeruginosa efflux pump research. All studies regarding Pseudomonas aeruginosa efflux that were published from 1994 to 2019 were retrieved from the Web of Science database, after which we conducted bibliographic coupling, co-authorship, co-citation, and co-occurrence analyses, and analyzed trends in Pseudomonas aeruginosa efflux pump research publications using the VOS Viewer software. RESULTS. We identified 2583 total publications that were included in this study. The number of relevant studies from around the world was found to be rising over time. The USA was identified as a central player in this research field at a global level, as studies from the USA had the most citations, the highest H-index values, and the greatest total link strength. Three primary research directions were identified through this analysis, including studies of efflux pump resistance mechanisms, transfer mechanisms, and inhibitors. CONCLUSIONS. Our visual analysis provides a quantitative overview for researchers who wish to quickly understand the past and current dynamics of the field of Pseudomonas aeruginosa efflux pump research. Overall, these findings suggest that future studies of efflux pump resistance mechanisms and efflux pump inhibitors may aid in overcoming clinical Pseudomonas aeruginosa resistance.
The Influence of Posterior Tibial Slope on the Mid-term Clinical Effect of Medial-pivot Knee Prosthesis
Authors: Shi Weipeng , Jiang Yaping , Zhao Xuan , Zhang Haining , Wang Yingzhen , Li Tao
Published: July 2021

Objective: To evaluate the effect of posterior tibial slope (PTS) on the mid-term clinical outcome following a medial-pivot (MP) prosthesis. Method: 233 patients from this hospital, who had undergone a total knee arthroplasty (TKA) with MP prosthesis between January 2015 and December 2015, were retrospectively included in this study. They were divided 3 groups according to postoperative PTS: A ≤ 5°; B 5-7° and C ≥ 7°. Multiple assessments were made on the patient postoperatively and recorded in the three groups, the measurements of this study included: The range of motion (ROM), knee scoring system (KSS), Western Ontario and McMaster universities osteoarthritis index (WOMAC), posterior condylar offset (PCO), joint line height and postoperative complications. Results: The average post-operative ROM for groups B and C were 108°and 110°respectively, this was significantly higher than that of group A (98°, P < 0.001). The WOMAC scores of patients in group C were significantly lower than those in groups A and B (p < 0.05). However, there were no significant differences in KSS, PCO, joint line height among the 3 groups (P>0.05). Only 2 cases of postoperative complications occurred in group C, these were recovered after operation. Conclusion: With an increase to PTS, the postoperative ROM can be significantly increased for the patient, however, the knee joint function will not be significantly improved, and the stability of knee joint will not be affected within the appropriate PTS.
Machine learning algorithms for the identification of potential non-syndromic intellectual disability associated miRNAs
Authors: Betancur Julián González , Guevara-Coto José , Romero Adarli
Published: July 2021

Background: Intellectual disabilities (IDs) are a group of developmental disorders with high phenotypic and genotypic heterogeneity. Association of genetic elements to IDs has typically been empirically accomplished, however recently, machine learning (ML) has proved to be an excellent instrument to elucidate these associations. miRNAs are short non-coding molecules that participate in spatiotemporal gene regulation, making them relevant for the understanding ID causality. Methods: In this study we used the BrainSpan spatio-temporal expression database to develop a series of machine learning predictors: SVM, RF, FF-ANN, and Stochastic Gradient Descent Classifier. These models were capable of recognizing gene expression profiles. The best classifier was used to label miRNAs associated with NS-IDs using the BrainSpan expression profiles. Results: The model with the best performance was a FF-ANN with 0.78 of F1-score, 0.78 of weighted recall and 0.78 of weighted precision. We used this model to identify miRNAs with high probability to be associated with NS-IDs using the spatio-temporal gene expression profile in the human brain. Labeled miRNAs that were annotated were associated with processes related to either IDs and-or neurodevelopmental processes. Conclusions: The development of a machine learning framework that identified potential NS-ID miRNAs represents an interesting approach for the identification of a potential list of on genes that could be subject for further experimental validation. This study also reinforces the potential of machine learning frameworks in their discovery of potential biomarkers that could improve disease detection and management.
Machine Learning-Guided Noninvasive Embryo Selection for Clinical in Vitro Fertilization Treatment to Avoid Wasting Potentially Qualified Embryos
Authors: Chen Li , Li Wen , Liu Yuxiu , Peng Zhihang , Cai Liyi , Zhang Ningyuan , Xu Juanjuan , Wang Liang , Teng Xiaoming , Yao Yaxin , Zou Yangyun , Ma Menglin , Liu Jianqiao , Lu Sijia , Sun Haixiang , Yao Bing
Published: July 2021

BackgroundThe success rates of in vitro fertilization (IVF) treatment are limited by the aneuploidy of human embryos. Pre-implantation genetic testing for aneuploidy(PGT-A) is often used to select embryos with normal ploidy but requires invasive embryo biopsy. MethodsWe performed chromosome sequencing of 345 paired blastocyst culture medium and whole blastocyst samples and developed a noninvasive embryo grading system based on the random forest machine-learning algorithm to predict blastocyst ploidy. The system was validated in 266 patients, and a blinded prospective observational study was performed to investigate clinical outcomes between machine learning-guided and traditional niPGT-A analyses. We graded embryos as A, B, or C using machine learning-guided niPGT-A analysis according to their euploidy probability levels predicted by noninvasive chromosomal screening. ResultsWe observed higher live birth rate in A- versus C-grade embryos (50.4% versus 27.1%, p=0.006) and B- versus C-grade embryos (45.3% versus 27.1%, p=0.022) and lower miscarriage rate in A- versus C-grade embryos (15.9% versus 33.3%, p=0.026) and B- versus C-grade embryos (14.3% versus 33.3%, p=0.021). The embryo utilization rate was significantly higher through machine learning strategy compared to the conventional dichotomic judgment of euploidy or aneuploidy in the niPGT-A analysis (78.8% versus 57.9%, p<0.001). We observed better outcomes in A- and B-grade embryos versus C-grade embryos and higher embryo utilization rates through machine learning strategies than traditional niPGT-A analysis. ConclusionThese results demonstrate that the machine learning-guided embryo grading system can optimize embryo selection and avoid wasting potential embryos.Trial registration﻿Chinese Clinical Trial Registry,ChiCTR-RRC-17010396.Registered 11 January 2017, http://www.chictr.org.cn/ChiCTR-RRC-17010396
Seasonal Dynamic of Cholecalciferol (D3) And Anti-Muellerian Hormone (AMH) With Impact On Ovarian Response And IVF/ICSI
Authors: Rogenhofer Nina , Jeschke Udo , von Schönfeldt Viktoria , Mahner Sven , Thaler Christian J.
Published: July 2021

Objective:Recent studies revealed intriguing associations between cholecalciferol (D3) and reproductive functions. Seasonal changes of D3 concentrations are well known, however they are not always considered in the context of reproductive functions. In this study, we analysed D3 serum concentration in IVF/ICSI patients with respect to seasonal 3-month quartiles and anti-Muellerian hormone (AMH) referring to the impact on Assisted Reproductive Technologies (ART) outcome. Materials and Research Methods:We studied 497 female patients, presenting between 2012 and 2018 for ART treatment in our fertility center. D3 as well as the AMH serum concentrations were measured at the beginning of the follicle stimulation (d 3-5 of menstrual cycles). Results were evaluated with respect to seasonal quartiles and outcome of the ART cycles. Results:D3 concentrations showed significant fluctuations within annual quartiles with a pronounced peak in August-October and a minimum in February-April (27.7mg/dl vs. 20.9mg/dl; p<0.0001). Similar seasonal dynamics were found for AMH (3.19ng/ml vs. 2.24ng/ml; p=0.013) and these were associated with significantly shorter stimulation periods during August-October (11.36d vs. 12.01d; p=0.044), higher number of fertilized oocytes between August-October (6.21 vs. 5.21; p=0.05) along with a trend towards higher numbers of Cumulus-Oocyte-complexes. However, no such differences were found for the numbers of MII-oocytes or pregnancy rates.Conclusion: Our data indicate, seasonal 3-month quartile variations of AMH concentrations and characteristics of ART, such as days of ovarian stimulation and number of fertilised oocytes. Highest AMH concentrations were found between August and October and this quartile was associated with highest D3 concentrations.