bluuebunny/crossref_metadata_2025 huggingface dataset:
Stability Analysis of the Rational Solutions, Periodic Cross-Rational Solutions, Rational Kink Cross-Solutions, and Homoclinic Breather Solutions to the KdV Dynamical Equation with Constant Coefficients and Their Applications
Authors: Seadawy Aly R. , Rizvi Syed T. R. , Zahed Hanadi
Published: February 2023

We explore various analytical rational solutions with symbolic computation using the ansatz transformation functions. We gain a variety of rational solutions such as M-shaped rational solutions (MSRs), periodic cross-rationals (PCRs), multi-wave solutions, rational kink cross-solutions (RKCs), and homoclinic breather solutions (HBs), and by using the appropriate values for the relevant parameters, their dynamics are visualized in figures. Additionally, two different types of interactions between MSRs and kink waves are analyzed. Furthermore, we examine the stability of the obtained solutions and create a corresponding table. We analyze the stability of these solutions and the movement role of the wave by making graphs as two-dimensional, three-dimensional and density graphs as well as contour visual and stream plots.
Snail: An Eco-Friendly Autonomous Steam Mopping Robot for Cleaning and Disinfection of Floors
Authors: Pookkuttath Sathian , Elara Mohan Rajesh , Mohan Rayguru Madan , Saldi Zaki Saptari , Sivanantham Vinu , Ramalingam Balakrishnan
Published: February 2023

Steam mopping is an eco-friendly solution for cleaning and disinfecting floors, avoiding harsh chemicals or harmful UV lights. Currently, commercial steam mopping systems are manually operated, which is laborious and unsafe. This work presents the design methodology of a novel, eco-friendly autonomous steam mopping robot named ‘Snail’ for cleaning and disinfecting typical indoor floors, namely tile, carpet, concrete, vinyl, sealed wood, and rugs. Our work is mainly focused on (1) the mechanical system design, including the locomotion, steam dispenser, and mopping unit, (2) the hardware and software architecture, and (3) the motion control system’s design for smooth maneuverability and mitigating friction forces. A high-gain friction estimator is proposed, whose output is exploited by the motion controller to follow the desired path and compensate for the traction-based locomotion disturbances due to extensive mop contact with a rough-textured floor, such as carpet. The proposed autonomous steam mopping robot’s efficiency is validated with different floors with zig-zagging cleaning patterns, setting a minimum of 100 °C as the disinfecting steam criterion. Using the proposed motion control algorithm, we validate the smooth maneuverability, assuring the robot traverses with a given speed and follows the trajectory even on a rough carpeted floor. The cleaning efficiency is tested by removing hard stains, consuming less water, and faster wet floor drying. The robot used only one liter of water to clean a 5 m2 floor area, and the drying time was found to be four times faster than normal water mopping. The proposed steam mopping robot design is ideal for cleaning and disinfecting hospitals and eldercare centers, where hygiene is crucial, and promoting going green, avoiding harsh chemicals, and mitigating current cleaner labor concerns, including the risk of infection.
A Multiplicative Calculus Approach to Solve Applied Nonlinear Models
Authors: Singh Gurjeet , Bhalla Sonia , Behl Ramandeep
Published: February 2023

Problems such as population growth, continuous stirred tank reactor (CSTR), and ideal gas have been studied over the last four decades in the fields of medical science, engineering, and applied science, respectively. Some of the main motivations were to understand the pattern of such issues and how to obtain the solution to them. With the help of applied mathematics, these problems can be converted or modeled by nonlinear expressions with similar properties. Then, the required solution can be obtained by means of iterative techniques. In this manuscript, we propose a new iterative scheme for computing multiple roots (without prior knowledge of multiplicity m) based on multiplicative calculus rather than standard calculus. The structure of our scheme stands on the well-known Schröder method and also retains the same convergence order. Some numerical examples are tested to find the roots of nonlinear equations, and results are found to be competent compared with ordinary derivative methods. Finally, the new scheme is also analyzed by the basin of attractions that also supports the theoretical aspects.
Pharmacology-Based Prediction of the Targets and Mechanisms for Icariin against Myocardial Infarction
Authors: Ke Zunping , Wang Yuling , Silimu Guzailinur , Wang Zhangsheng , Gao Aimei
Published: February 2023

Background and Objectives: This study aims to illustrate the mechanisms underlying the therapeutic effect of Icariin after myocardial infarction (MI). Materials and Methods: Based on the network pharmacology strategy, we predict the therapeutic targets of Icariin against MI and investigate the pharmacological molecular mechanisms. A topological network was created. Biological process and Kyoto Encyclopedia of Genes and Genomes pathway enrichment were also performed. We also conducted the molecular docking analysis to stimulate the component–target interaction further and validate the direct bind effect. Results: Network pharmacology analysis identified 61 candidate genes related to the therapeutic effect of Icariin against MI. EGFR, AKT1, TP53, JUN, ESR1, PTGS2, TNF, RELA, HSP90AA1, and BCL2L1 were identified as hub genes. The biological processes of the candidate targets were significantly involved in the reactive oxygen species metabolic process, response to hypoxia, response to decreased oxygen levels, response to oxidative stress, regulation of reactive oxygen species metabolic process, and so forth. Overall, biological process enrichment analysis indicated that the protective effect of Icariin against MI might be associated with oxidative stress. Moreover, the pathway analysis showed that the candidate targets were closely associated with lipid and atherosclerosis, AGE-RAGE signaling pathway in diabetic complications, HIF-1 signaling pathway, etc. We identified the conformation with the lowest affinity score as the docking conformation. The simulated molecular docking was displayed to illustrate the topical details of the binding sites between Icariin and TNF protein. Conclusions: This study provides an overview of the mechanisms underlying the protective effect of Icariin against MI.
Mininvasive Cytoreduction Surgery plus HIPEC for Epithelial Ovarian Cancer: A Systematic Review
Authors: Ronsini Carlo , Pasanisi Francesca , Greco Pierfrancesco , Cobellis Luigi , De Franciscis Pasquale , Cianci Stefano
Published: February 2023

Background and objectives: The Gold-Standard treatment for Advanced Epithelial Ovarian Cancer remains cytoreductive surgery followed by systemic chemotherapy. Surgery can be performed either by an open or minimally invasive approach (MIS), although the former remains the most widely used approach. Recently, Van Driel et al. proved that adding 100 mg/m2 of Cisplatin in Hyperthermic Intraperitoneal Chemotherapy (HIPEC) at Interval Debulking Surgery (IDS) gives a disease-free survival (DFS) advantage. Similarly, Gueli-Alletti et al. demonstrated how the MIS approach is feasible and safe in IDS. Moreover, Petrillo et al. reported pharmacokinetic profiles with a higher chemotherapy concentration in patients undergoing HIPEC after MIS compared with the open approach. Therefore, the following review investigates the oncological and clinical safety consequences of the association between MIS and HIPEC. Methods: Following the recommendations in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, we systematically searched the PubMed and Scopus databases in April 2022. Studies containing data about oncological and safety outcomes were included. We registered the Review to the PROSPERO site for meta-analysis with protocol number CRD42022329503. Results: Five studies fulfilled inclusion criteria. 42 patients were included in the review from three different Gynecological Oncological referral centers. The systematic review highlighted a Recurrence Rate ranging between 0 and 100%, with a 3-year Platinum-Free Survival between 10 and 70%. The most common HIPEC drug was Cisplatin, used at concentrations between 75 and 100 mg/m2 and at an average temperature of 42 °C, for 60 to 90 min. Only 1 Acute Kidney Insufficiency has been reported. Conclusions: The scarcity of clinical trials focusing on a direct comparison between MIS and the open approach followed by HIPEC in EOC treatment does not make it possible to identify an oncological advantage between these two techniques. However, the safety profiles shown are highly reassuring.
A Ribosome-Related Prognostic Signature of Breast Cancer Subtypes Based on Changes in Breast Cancer Patients’ Immunological Activity
Authors: Luan Tiankuo , Song Daqiang , Liu Jiazhou , Wei Yuxian , Feng Rui , Wang Xiaoyu , Gan Lin , Wan Jingyuan , Fang Huiying , Li Hongzhong , Gong Xia
Published: February 2023

Background and Objectives. The prognostic role of adjacent nontumor tissue in patients with breast cancer (BC) is still unclear. The activity changes in immunologic and hallmark gene sets in normal tissues adjacent to BC may play a crucial role in predicting the prognosis of BC patients. The aim of this study was to identify BC subtypes and ribosome-associated prognostic genes based on activity changes of immunologic and hallmark gene sets in tumor and adjacent nontumor tissues to improve patient prognosis. Materials and Methods. Gene set variation analysis (GSVA) was applied to assess immunoreactivity changes in the overall sample and three immune-related BC subtypes were identified by non-negative matrix factorization (NMF). KEGG (Kyoto Encyclopedia of Genes and Genomes) and GO (Gene Ontology) analyses were after determining the prognostic gene set using the least absolute shrinkage and selection operator (LASSO) method. Ribosome-related genes were identified by PPI (protein-protein interaction) analysis, and finally a prognostic risk model was constructed based on the expression of five ribosomal genes (RPS18, RPL11, PRLP1, RPL27A, and RPL38). Results. A comprehensive analysis of immune and marker genomic activity changes in normal breast tissue and BC tissue identified three immune-related BC subtypes. BC subtype 1 has the best prognosis, and subtype 3 has the worst overall survival rate. We identified a prognostic gene set in nontumor tissue by the least absolute shrinkage and selection operator (LASSO) method. We found that the results of both KEGG and GO analyses were indistinguishable from those of ribosome-associated genes. Finally, we determined that genes associated with ribosomes exhibit potential as a reliable predictor of overall survival in breast cancer patients. Conclusions. Our research provides an important guidance for the treatment of BC. After a mastectomy, the changes in gene set activity of both BC tissues and the nontumor tissues adjacent to it should be thoroughly evaluated, with special attention to changes in ribosome-related genes in the nontumor tissues.
Patient-Specific Guides for Accurate and Precise Positioning of Osseointegrated Implants in Transfemoral Amputations: A Proof-of-Concept In Vitro Study
Authors: Benca Emir , Ferrante Beatrice , Unger Ewald , Strassl Andreas , Hirtler Lena , Brånemark Rickard , Windhager Reinhard , Hobusch Gerhard M.
Published: February 2023

Background and Objectives: The treatment of transfemoral amputees using osseointegrated implants for prosthetic anchorage requires accurate implant positioning when using threaded bone-anchoring implants due to the curvature of the femur and the risk of cortical penetration in misaligned implants. This study investigated the accuracy and precision in implant positioning using additively manufactured case-specific positioning guides. Materials and Methods: The geometry and density distribution of twenty anatomic specimens of human femora were assessed in quantitative computed tomography (QCT) scanning. The imaging series were used to create digital 3D specimen models, preoperatively plan the optimal implant position and manufacture specimen-specific positioning guides. Following the surgical bone preparation and insertion of the fixture (threaded bone-anchoring element) (OPRA; Integrum AB, Mölndal, Sweden), a second QCT imaging series and 3D model design were conducted to assess the operatively achieved implant position. The 3D models were registered and the deviations of the intraoperatively achieved implant position from the preoperatively planned implant position were analyzed as follows. The achieved, compared to the planned implant position, was presented as resulting mean hip abduction or adduction (A/A) and extension or flexion (E/F) and mean implant axis offset in medial or lateral (M/L) and anterior or posterior (A/P) direction measured at the most distal implant axis point. Results: The achieved implant position deviated from the preoperative plan by 0.33 ± 0.33° (A/A) and 0.68 ± 0.66° (E/F) and 0.62 ± 0.55 mm (M/L) and 0.68 ± 0.56 mm (A/P), respectively. Conclusions: Using case-specific guides, it was feasible to achieve not only accurate but also precise positioning of the implants compared to the preoperative plan. Thus, their design and application in the clinical routine should be considered, especially in absence of viable alternatives.
Electrodialysis Deacidification of Acid Hydrolysate in Hemicellulose Saccharification Process: Membrane Fouling Identification and Mechanisms
Authors: Luo Xitao , Sun Lingling , Shou Qinghui , Liang Xiangfeng , Liu Huizhou
Published: February 2023

Acid saccharification of hemicelluloses offers promising pathways to sustainably diversify the revenue of the lignocellulose biorefinery industry. Electrodialysis to separate inorganic acids from acid hydrolysate in the hemicellulose saccharification process could realize the recovery of sulfuric acid, and significantly reduced the chemical consumption than the traditional ion exchange resins method. In this work, the deacidification of corncob acid hydrolysate was conducted by a homemade electrodialysis apparatus. The results showed that: (1) more than 99% of acid can be removed through the electrodialysis process; (2) A non-negligible membrane fouling occurred during the electrodialysis process, which aggravated with the repeated batch running The final global system resistance rose from 15.8 Ω (1st batch) to 43.9 Ω (10th batch), and the treatment ending time was delayed from 120 min (1st batch) to 162 min (10th batch); (4) About 90% of protein, 70% of ferulate acid, and 80% of p-coumarate acid precipitated from the corncob acid hydrolysate during the electrodialysis process. The zeta potential of corncob acid hydrolysate changed from a positive value to a negative value, and an isoelectric point around pH 2.3 was reached. HSQC, FTTR, and GPC, along with SEM and EDS analysis, revealed that the fouling layers mostly consisted of hydrolysates of protein and lignin. The result of HSQC indicated that the membrane foulant may exist in the form of lignin–carbohydrate complexes, as the lignin component of the membrane foulant is in the form of p-coumarate and ferulate. From the result of FTIR, a strong chemical bonding, such as a covalent linkage, existed between the lignin and protein in the membrane foulant. Throughout the electrodialysis process, the increased pH decreased the stability of colloidal particles, including lignin and proteins. Destabilized colloidal particles started to self-aggregate and form deposits on the anion exchange membrane’s surface. Over time, these deposits covered the entire membrane surface and the spaces between the membranes. Eventually, they attached to the surface of the cation exchange membrane. In the end, a suggestion to control and minimize membrane fouling in this process was discussed: lower pH as a process endpoint and a post-treatment method.
The Impact of COVID-19 on Women and Work: Career Advancement Challenges
Authors: Lafkas Sara McPhee , Christensen Marin , Madsen Susan R.
Published: February 2023

The COVID-19 pandemic upended countless lives all over the world. Considerable research has shown that women’s career progression has been more negatively impacted by the pandemic than men’s, especially in the wake of school closures and increased childcare responsibilities. In order to understand more deeply the impact of the pandemic on women’s careers, a large mixed-method survey was conducted in Utah, a western state in the United States. This article reports on the responses of 2564 respondents to one of three open-ended questions taken from the overall survey, namely: “How has the pandemic impacted your career advancement experiences and opportunities over the short term and longer term?” The article frames the findings of this question by outlining workplace conditions and structures that contributed to women not advancing prior to the pandemic and applies the lenses of identity theory and systems psychodynamic theory to illustrate tendencies for workers and organizations to maintain the gendered dynamics that impede women’s career advancement. Findings included 59.1 percent of respondents who described a negative effect on their career advancement caused by the pandemic. Overarching themes and sub-themes were identified from these negative effects. Overarching themes included: (1) “Everything is on hold”; (2) “Lost or relinquished opportunity”; (3) “Reevaluation of Career”; and (4) “Experiences by Characteristics.” The latter theme highlighted unique experiences women faced versus men and manifested the gendered dynamics identified by identity and psychodynamic theories. Findings highlighted the importance of making workplace changes such as more flexible work and/or hybrid work arrangements, improved leave policies, the provision of childcare and other support services, and government policies that eliminate gendered barriers to women’s career advancement.
Influence on Pitting Corrosion Resistance of AISI 301LN and 316L Stainless Steels Subjected to Cold-Induced Deformation
Authors: Silva Paulo M. O. , Filho Mucio C. C. , da Cruz José A. , Sales Antonio J. M. , Sombra Antonio S. B. , Tavares João Manuel R. S.
Published: February 2023

Austenitic stainless steels that exhibit good corrosion resistance have recently found increasing applications in industry and transportation. This article addresses the influence of cold rolling and deformation on the pitting corrosion resistance of AISI 301LN and 316L stainless steels. The results indicate that the content of martensite increases as the cold rolling reduction also increases. The current work combined different techniques such as optical microscopy and scanning electron microscopy (SEM) with energy dispersive X-ray spectroscopy (EDS) analyses. Corrosion tests were carried out, in accordance with the ASTM standards. The results confirm that the 316L steel performed better than the 301LN, regarding pitting corrosion, even when deformed. This is due to the high molybdenum (Mo) content, which guarantees greater corrosion resistance. The conducted corrosion tests showed that the increase of cold deformation reduces the resistance to pitting and overall corrosion in both steels. It was found that the 301LN stainless steel has higher susceptibility to deformation-induced martensite and, despite the addition of nitrogen, it still has a lower performance relative to the 316L steel. The current work focused on evaluating the formation of pits and the dynamics of the microstructures of the AISI 301LN and 316L steels with their mechanical properties and corrosion resistance in a saline environment including chlorides.
Impact of Submerged Entry Nozzle (SEN) Immersion Depth on Meniscus Flow in Continuous Casting Mold under Electromagnetic Brake (EMBr)
Authors: Vakhrushev Alexander , Karimi-Sibaki Ebrahim , Bohacek Jan , Wu Menghuai , Ludwig Andreas , Tang Yong , Hackl Gernot , Nitzl Gerald , Watzinger Josef , Kharicha Abdellah
Published: February 2023

Complex multi-phase phenomena, including turbulent flow, solidification, and magnetohydrodynamics (MHD) forces, occur during the continuous casting (CC) under the applied electromagnetic brake (EMBr). The results of the small-scale experiment of the liquid metal model for continuous casting (mini-LIMMCAST) at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR), investigating MHD flow with a deep immersion depth of 100 mm, are supplemented by newly presented numerical studies with the shallow position of the submerged entry nozzle (SEN) at 50 mm below the meniscus. Herein, the focus is on the MHD effects at the meniscus level considering (i) a fully insulating domain boundary, (ii) a perfectly conductive mold, or (iii) the presence of the solid shell. The volume-of-fluid (VOF) approach is utilized to model a Galinstan flow, including free surface behavior. A multiphase solver is developed using conservative MHD formulations in the framework of the open-source computational fluid dynamics (CFD) package OpenFOAM®. The wall-adapting local eddy-viscosity (WALE) subgrid-scale (SGS) model is employed to model the turbulent effects on the free surface flow. We found that, for the deep immersion depth, the meniscus remains calm under the EMBr for the conductive and semi-conductive domain. For the insulated mold disregarding the SEN position, the self-inducing MHD vortices, aligned with the magnetic field, cause strong waving of the meniscus and air bubble entrapment for shallow immersion depth. Secondary MHD structures can form close to the meniscus under specific conditions. The influence of the EMBr and immersion depth on the flow energy characteristics is analyzed using power spectral density (PSD).
Synergistic Effects of Hydrostatic Pressure and Dissolved Oxygen on the SCC Behavior of Hydrogenated Ti6Al4V Alloy in Deep-Sea Environment
Authors: Huang Feifei , Zhu Yuxiang , Yu Meng , Wen Lei , Jin Ying
Published: February 2023

This work focused on the synergistic effect of hydrostatic pressure (HP) within the range of 0.1~50 MPa and a dissolved oxygen (DO) concentration within the range of 0.18~11.8 ppm on the stress corrosion cracking (SCC) behavior of hydrogenated Ti6Al4V alloy in a simulated deep-sea environment by electrochemical measurements and slow strain rate tensile (SSRT) tests. The potentiodynamic polarization and electrochemical impedance spectra results confirmed the corrosion resistance degradation with the HP increasing to 50 MPa. The fracture morphologies showed a mixed characteristic of brittle fracture on the surface layer and ductile fracture in the inner part. Higher HPs increased SCC susceptibility while a larger DO concentration decrease that of Ti6Al4V alloy.
Corrosion Behavior of Refractory High-Entropy Alloys in FLiNaK Molten Salts
Authors: Patel Kunjal , Mahajan Chaitanya , Muskeri Saideep , Mukherjee Sundeep
Published: February 2023

Refractory high-entropy alloys (RHEAs) have recently attracted widespread attention due to their outstanding mechanical properties at elevated temperatures, making them appealing for concentrating solar power and nuclear energy applications. Here, the corrosion behavior of equimolar HfTaTiVZr and TaTiVWZr RHEAs was investigated in molten FLiNaK eutectic salt (LiF-NaF-KF: 46.5−11.5−42 mol.%) at 650 °C. Potentiodynamic polarization, electrochemical impedance spectroscopy (EIS), and immersion test measurements were carried out for these two RHEAs and compared with Inconel 718 (IN718) superalloy and SS316 stainless steel under identical test conditions. Both TaTiVWZr and HfTaTiVZr refractory high-entropy alloys exhibited an order of magnitude lower corrosion rate than SS316. IN718 and TaTiVWZr showed similar corrosion rates. Corrosion products enriched with noble alloying elements formed in the case of TaTiVWZr and IN718 were stable and protective on the substrate. SS316 showed the lowest corrosion resistance and void formation along the exposed surface due to the active dissolution of Cr and Fe, which provided diffusion paths for the corroded species. The surface analysis results showed that IN718 underwent pitting corrosion, while TaTiVWZr experienced selective dissolution in the inter-dendritic area. In contrast, HfTaTiVZr and SS316 experienced corrosion at the grain boundaries.
Optical Recrystallization of Nanocrystalline Silicon Ribbons
Authors: Serra Filipe , Costa Ivo , Silva José A. , Serra João M.
Published: February 2023

The Silicon on Dust Substrate (SDS) is a gas-to-wafer process that produces multicrystalline silicon ribbons directly from gaseous feedstock (silane), avoiding the standard industry steps of polysilicon deposition, crystal growth, and wafering. The SDS technique consists of three main steps: (i) micrometric-sized silicon powder production by grinding silicon chunks; (ii) chemical vapor deposition (CVD) of silicon over this silicon powder substrate; and (iii) zone-melting recrystallization (ZMR) of the nanocrystalline pre-ribbon obtained in the CVD step. Several samples were produced by this technique. During CVD, mechanically self-sustained nanocrystalline pre-ribbons were grown over silicon powder substrates, with growth rates in the order of 50 µm/min. The ZMR process performance is substantially impacted by the pre-ribbon physical characteristics. The best and largest recrystallizations were achieved on pre-ribbons grown over powder substrates with smaller particle sizes, which also have lower substrate powder incorporation ratios. Multicrystalline silicon ribbons with crystalline areas as large as 2 × 4 cm2 were successfully produced. These areas have visible columnar crystal growth with crystal lengths up to 1 cm. The SDS ribbons’ measured resistivity confirmed the high powder content of the resulting material. The ability to produce solar cells on SDS multicrystalline silicon ribbons was demonstrated.
Enantioselective Recognition of L-Lysine by ICT Effect with a Novel Binaphthyl-Based Complex
Authors: Tang Shi , Wei Zhaoqin , Guo Jiani , Sun Xiaoxia , Hu Yu
Published: February 2023

A novel triazole fluorescent sensor was efficiently synthesized using binaphthol as the starting substrate with 85% total end product yield. This chiral fluorescence sensor was proved to have high specific enantioselectivity for lysine. The fluorescence intensity of R-1 was found to increase linearly when the equivalent amount of L-lysine (0–100 eq.) was gradually increased in the system. The fluorescence intensity of L-lysine to R-1 was significantly enhanced, accompanied by the red-shift of emission wavelength (389 nm to 411 nm), which was attributed to the enhanced electron transfer within the molecular structure, resulting in an ICT effect, while the fluorescence response of D-lysine showed a decreasing trend. The enantioselective fluorescence enhancement ratio for the maximum fluorescence intensity was 31.27 [ef = |(IL − I0)/(ID − I0)|, 20 eq. Lys], thus it can be seen that this fluorescent probe can be used to identify and distinguish between different configurations of lysine.
Review of Intelligence for Additive and Subtractive Manufacturing: Current Status and Future Prospects
Authors: Rahman M. Azizur , Saleh Tanveer , Jahan Muhammad Pervej , McGarry Conor , Chaudhari Akshay , Huang Rui , Tauhiduzzaman M. , Ahmed Afzaal , Mahmud Abdullah Al , Bhuiyan Md. Shahnewaz , Khan Md Faysal , Alam Md. Shafiul , Shakur Md Shihab
Published: February 2023

Additive manufacturing (AM), an enabler of Industry 4.0, recently opened limitless possibilities in various sectors covering personal, industrial, medical, aviation and even extra-terrestrial applications. Although significant research thrust is prevalent on this topic, a detailed review covering the impact, status, and prospects of artificial intelligence (AI) in the manufacturing sector has been ignored in the literature. Therefore, this review provides comprehensive information on smart mechanisms and systems emphasizing additive, subtractive and/or hybrid manufacturing processes in a collaborative, predictive, decisive, and intelligent environment. Relevant electronic databases were searched, and 248 articles were selected for qualitative synthesis. Our review suggests that significant improvements are required in connectivity, data sensing, and collection to enhance both subtractive and additive technologies, though the pervasive use of AI by machines and software helps to automate processes. An intelligent system is highly recommended in both conventional and non-conventional subtractive manufacturing (SM) methods to monitor and inspect the workpiece conditions for defect detection and to control the machining strategies in response to instantaneous output. Similarly, AM product quality can be improved through the online monitoring of melt pool and defect formation using suitable sensing devices followed by process control using machine learning (ML) algorithms. Challenges in implementing intelligent additive and subtractive manufacturing systems are also discussed in the article. The challenges comprise difficulty in self-optimizing CNC systems considering real-time material property and tool condition, defect detections by in-situ AM process monitoring, issues of overfitting and underfitting data in ML models and expensive and complicated set-ups in hybrid manufacturing processes.
Sustainable and Cost-Effective Gel Documentation
Authors: Asad Nadeem , Cregg Scott , Shakya Sudeep , Stegman Sutton , Timmons Lisa
Published: February 2023

A common laboratory method involves gel electrophoresis followed by photographic documentation of the results, a procedure which is performed worldwide by students and experienced scientists alike. Proprietary Gel Documentation Systems are convenient and useful for documentation of electrophoresis results, but the systems can be prohibitively expensive to purchase and repair, they contain features that are not necessary for everyday documentation, and some users may not find the systems intuitive to operate. We describe our gel documentation setup that meets the everyday needs for documentation in our lab. The setup is inexpensive, modular, user friendly, and increases sustainability through extending the working life of obsolete cell phones, iPads, or other electronic devices containing a camera. More importantly, the setup completely shields users from potentially damaging ultraviolet radiation.
Energetic Electron-Assisted Synthesis of Tailored Magnetite (Fe3O4) and Maghemite (γ−Fe2O3) Nanoparticles: Structure and Magnetic Properties
Authors: Dietrich Johannes , Enke Alexius , Wilharm Nils , Konieczny Robert , Lotnyk Andriy , Anders André , Mayr Stefan G.
Published: February 2023

Iron oxide nanoparticles with a mean size of approximately 5 nm were synthesized by irradiating micro-emulsions containing iron salts with energetic electrons. The properties of the nanoparticles were investigated using scanning electron microscopy, high-resolution transmission electron microscopy, selective area diffraction and vibrating sample magnetometry. It was found that formation of superparamagnetic nanoparticles begins at a dose of 50 kGy, though these particles show low crystallinity, and a higher portion is amorphous. With increasing doses, an increasing crystallinity and yield could be observed, which is reflected in an increasing saturation magnetization. The blocking temperature and effective anisotropy constant were determined via zero-field cooling and field cooling measurements. The particles tend to form clusters with a size of 34 nm to 73 nm. Magnetite/maghemite nanoparticles could be identified via selective area electron diffraction patterns. Additionally, goethite nanowires could be observed.
Proton Therapy, Magnetic Nanoparticles and Hyperthermia as Combined Treatment for Pancreatic BxPC3 Tumor Cells
Authors: Brero Francesca , Calzolari Paola , Albino Martin , Antoccia Antonio , Arosio Paolo , Berardinelli Francesco , Bettega Daniela , Ciocca Mario , Facoetti Angelica , Gallo Salvatore , Groppi Flavia , Innocenti Claudia , Laurenzana Anna , Lenardi Cristina , Locarno Silvia , Manenti Simone , Marchesini Renato , Mariani Manuel , Orsini Francesco , Pignoli Emanuele , Sangregorio Claudio , Scavone Francesca , Veronese Ivan , Lascialfari Alessandro
Published: February 2023

We present an investigation of the effects on BxPC3 pancreatic cancer cells of proton therapy combined with hyperthermia, assisted by magnetic fluid hyperthermia performed with the use of magnetic nanoparticles. The cells’ response to the combined treatment has been evaluated by means of the clonogenic survival assay and the estimation of DNA Double Strand Breaks (DSBs). The Reactive Oxygen Species (ROS) production, the tumor cell invasion and the cell cycle variations have also been studied. The experimental results have shown that the combination of proton therapy, MNPs administration and hyperthermia gives a clonogenic survival that is much smaller than the single irradiation treatment at all doses, thus suggesting a new effective combined therapy for the pancreatic tumor. Importantly, the effect of the therapies used here is synergistic. Moreover, after proton irradiation, the hyperthermia treatment was able to increase the number of DSBs, even though just at 6 h after the treatment. Noticeably, the magnetic nanoparticles’ presence induces radiosensitization effects, and hyperthermia increases the production of ROS, which contributes to cytotoxic cellular effects and to a wide variety of lesions including DNA damage. The present study indicates a new way for clinical translation of combined therapies, also in the vision of an increasing number of hospitals that will use the proton therapy technique in the near future for different kinds of radio-resistant cancers.
Identification of the Segregation Kinetics of Ultrathin GaAsSb/GaAs Films Using AlAs Markers
Authors: Gonzalez David , Flores Sara , Braza Verónica , Reyes Daniel F. , Carro Alejandro Gallego , Stanojević Lazar , Schwarz Malte , Ulloa Jose María , Ben Teresa
Published: February 2023

For optoelectronic devices from the near to the far infrared, the advantages of using ultrathin III-Sb layers as quantum wells or in superlattices are well known. However, these alloys suffer from severe surface segregation problems, so that the actual profiles are very different from the nominal ones. Here, by inserting AlAs markers within the structure, state-of-the-art transmission electron microscopy techniques were used to precisely monitor the incorporation/segregation of Sb in ultrathin GaAsSb films (from 1 to 20 monolayers (MLs)). Our rigorous analysis allows us to apply the most successful model for describing the segregation of III-Sb alloys (three-layer kinetic model) in an unprecedented way, limiting the number of parameters to be fitted. The simulation results show that the segregation energy is not constant throughout the growth (which is not considered in any segregation model) but has an exponential decay from 0.18 eV to converge asymptotically towards 0.05 eV. This explains why the Sb profiles follow a sigmoidal growth model curve with an initial lag in Sb incorporation of 5 MLs and would be consistent with a progressive change in surface reconstruction as the floating layer is enriched.
PbS Quantum Dots-Decorated BiVO4 Photoanodes for Highly Efficient Photoelectrochemical Hydrogen Production
Authors: Seo Joo-Won , Ha Seung-Beom , Song In-Cheul , Kim Jae-Yup
Published: February 2023

While metal oxides such as TiO2, Fe2O3, WO3, and BiVO4 have been previously studied for their potential as photoanodes in photoelectrochemical (PEC) hydrogen production, their relatively wide band-gap limits their photocurrent, making them unsuitable for the efficient utilization of incident visible light. To overcome this limitation, we propose a new approach for highly efficient PEC hydrogen production based on a novel photoanode composed of BiVO4/PbS quantum dots (QDs). Crystallized monoclinic BiVO4 films were prepared via a typical electrodeposition process, followed by the deposition of PbS QDs using a successive ionic layer adsorption and reaction (SILAR) method to form a p-n heterojunction. This is the first time that narrow band-gap QDs were applied to sensitize a BiVO4 photoelectrode. The PbS QDs were uniformly coated on the surface of nanoporous BiVO4, and their optical band-gap was reduced by increasing the number of SILAR cycles. However, this did not affect the crystal structure and optical properties of the BiVO4. By decorating the surface of BiVO4 with PbS QDs, the photocurrent was increased from 2.92 to 4.88 mA/cm2 (at 1.23 VRHE) for PEC hydrogen production, resulting from the enhanced light-harvesting capability arising from the narrow band-gap of the PbS QDs. Moreover, the introduction of a ZnS overlayer on the BiVO4/PbS QDs further improved the photocurrent to 5.19 mA/cm2, attributed to the reduction in interfacial charge recombination.
Cluster-Assembled Zirconia Substrates Accelerate the Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells
Authors: Castiglioni Sara , Locatelli Laura , Cazzaniga Alessandra , Orecchio Francesca Maria , Santaniello Tommaso , Piazzoni Claudio , Bureau Lionel , Borghi Francesca , Milani Paolo , Maier Jeanette A.
Published: February 2023

Due to their high mechanical strength and good biocompatibility, nanostructured zirconia surfaces (ns-ZrOx) are widely used for bio-applications. Through supersonic cluster beam deposition, we produced ZrOx films with controllable roughness at the nanoscale, mimicking the morphological and topographical properties of the extracellular matrix. We show that a 20 nm ns-ZrOx surface accelerates the osteogenic differentiation of human bone marrow-derived MSCs (bMSCs) by increasing the deposition of calcium in the extracellular matrix and upregulating some osteogenic differentiation markers. bMSCs seeded on 20 nm ns-ZrOx show randomly oriented actin fibers, changes in nuclear morphology, and a reduction in mitochondrial transmembrane potential when compared to the cells cultured on flat zirconia (flat-ZrO2) substrates and glass coverslips used as controls. Additionally, an increase in ROS, known to promote osteogenesis, was detected after 24 h of culture on 20 nm ns-ZrOx. All the modifications induced by the ns-ZrOx surface are rescued after the first hours of culture. We propose that ns-ZrOx-induced cytoskeletal remodeling transmits signals generated by the extracellular environment to the nucleus, with the consequent modulation of the expression of genes controlling cell fate.
Heat Transfer Enhancement by Hybrid Nano Additives—Graphene Nanoplatelets/Cellulose Nanocrystal for the Automobile Cooling System (Radiator)
Authors: Yaw Chong Tak , Koh S. P. , Sandhya M. , Kadirgama K. , Tiong Sieh Kiong , Ramasamy D. , Sudhakar K. , Samykano M. , Benedict F. , Tan Chung Hong
Published: February 2023

A radiator is used to remove a portion of the heat generated by a vehicle engine. It is challenging to efficiently maintain the heat transfer in an automotive cooling system even though both internal and external systems need enough time to keep pace with catching up with evolving engine technology advancements. The effectiveness of a unique hybrid’s heat transfer nanofluid was investigated in this study. The hybrid nanofluid was mainly composed of graphene nanoplatelets (GnP), and cellulose nanocrystals (CNC) nanoparticles suspended in a 40:60 ratio of distilled water and ethylene glycol. A counterflow radiator equipped with a test rig setup was used to evaluate the hybrid nano fluid’s thermal performance. According to the findings, the proposed GNP/CNC hybrid nanofluid performs better in relation to improving the efficiency of heat transfer of a vehicle radiator. The suggested hybrid nanofluid enhanced convective heat transfer coefficient by 51.91%, overall heat transfer coefficient by 46.72%, and pressure drop by 34.06% with respect to distilled water base fluid. Additionally, the radiator could reach a better CHTC with 0.01% hybrid nanofluid in the optimized radiator tube by the size reduction assessment using computational fluid analysis. In addition to downsizing the radiator tube and increasing cooling capacity over typical coolants, the radiator takes up less space and helps to lower the weight of a vehicle engine. As a result, the suggested unique hybrid graphene nanoplatelets/cellulose nanocrystal-based nanofluids perform better in heat transfer enhancement in automobiles.
Enhanced Nutraceutical Properties of Extra Virgin Olive Oil Extract by Olive Leaf Enrichment
Authors: Cuffaro Doretta , Bertini Simone , Macchia Marco , Digiacomo Maria
Published: February 2023

(1) Background: Nowadays, the health-promoting properties of extra virgin olive oil (EVOO), including the antioxidant and anti-inflammatory actions, are well recognized and mainly attributed to the different polyphenols, such as oleocanthal and oleacein. In EVOO production, olive leaves represent a high value by-product, showing a wide spectrum of beneficial effects due to the presence of polyphenols, especially oleuropein. Here we report the study of olive leaf extract (OLE)-enriched EVOO extracts, obtained by adding different percentages of OLE to EVOO in order to ameliorate their nutraceutical activities. (2) Methods: The polyphenolic content of the EVOO/OLE extracts was analyzed by HPLC and the Folin-Ciocalteau assay. For further biological testing, an 8% OLE-enriched EVOO extract was chosen. Therefore, antioxidant effects were evaluated by three different methods (DPPH, ABTS, and FRAP), and the anti-inflammatory properties were assessed in terms of cyclooxygenase activity inhibition. (3) Results: The antioxidant and anti-inflammatory profiles of the new EVOO/OLE extract are significantly improved compared to those of EVOO extract; (4) Conclusions: The combination of OLE and EVOO extract can lead to an extract enriched in terms of bioactive polyphenols and endowed with better biological properties than the singular EVOO extract. Therefore, it may represent a new complement in the nutraceutical field.
Metabolic Syndrome and Its Components Are Associated with New-Onset Hyperuricemia in a Large Taiwanese Population Follow-Up Study
Authors: Tu Yen-Chieh , Liu Yi-Hsueh , Chen Szu-Chia , Su Ho-Ming
Published: February 2023

The prevalence rate of hyperuricemia remains high in Taiwan, at 21.6% in men and 9.57% in women. Both metabolic syndrome (MetS) and hyperuricemia can cause many complications; however, few studies have evaluated the correlation between MetS and hyperuricemia. Therefore, in this observational cohort study, we explored associations between metabolic syndrome (MetS) and its components and new-onset hyperuricemia. Of 27,033 individuals in the Taiwan Biobank who had complete follow-up data, we excluded those with hyperuricemia at baseline (n = 4871), those with gout at baseline (n = 1043), those with no data on baseline uric acid (n = 18), and those with no data on follow-up uric acid (n = 71). The remaining 21,030 participants (mean age 50.8 ± 10.3 years) were enrolled. We found a significant association between new-onset hyperuricemia with MetS and the components of MetS (hypertriglyceridemia, abdominal obesity, low high-density lipoprotein cholesterol, hyperglycemia, and high blood pressure). Furthermore, compared to those without any MetS components, those with one MetS component (OR = 1.816), two MetS components (OR = 2.727), three MetS components (OR = 3.208), four MetS components (OR = 4.256), and five MetS components (OR = 5.282) were significantly associated with new-onset hyperuricemia (all p < 0.001). MetS and its five components were associated with new-onset hyperuricemia in the enrolled participants. Further, an increase in the number of MetS components was associated with an increase in the incidence rate of new-onset hyperuricemia.
Osteoporosis and Celiac Disease: Updates and Hidden Pitfalls
Authors: Lungaro Lisa , Manza Francesca , Costanzini Anna , Barbalinardo Marianna , Gentili Denis , Caputo Fabio , Guarino Matteo , Zoli Giorgio , Volta Umberto , De Giorgio Roberto , Caio Giacomo
Published: February 2023

Celiac disease (CD) is an autoimmune disorder caused by gluten ingestion in genetically predisposed individuals. In addition to the typical gastrointestinal symptoms (e.g., diarrhea, bloating, and chronic abdominal pain), CD may also present with a broad spectrum of manifestations, including low bone mineral density (BMD) and osteoporosis. The etiopathology of bone lesions in CD is multifactorial and other conditions, rather than mineral and vitamin D malabsorption, may affect skeletal health, especially those related to the endocrine system. Here, we describe CD-induced osteoporosis in an attempt to enlighten new and less-known aspects, such as the influence of the intestinal microbiome and sex-related differences on bone health. This review describes the role of CD in the development of skeletal alterations to provide physicians with an updated overview on this debated topic and to improve the management of osteoporosis in CD.
Improving Iodine Intake in Rural Haiti through Social Enterprise: A Cross-Sectional Study in the Central Plateau
Authors: Barloggio Nora , Jean Fr. Herald , Thelus Ben Ali , Jocenais Pierre , Wirth Gilbert J. , Boothby Neil , Schuenke-Lucien Kate , Rigutto-Farebrother Jessica
Published: February 2023

Iodine intake in Haiti has increased in recent years thanks to the “Bon Sel” social enterprise approach to salt fortification and distribution by the market segment. However, it was uncertain whether this salt reached remote communities. This cross-sectional study aimed to assess the iodine status of school-age children (SAC) and women of reproductive age (WRA) in a remote region of the Central Plateau. A total of 400 children (9–13 years) and 322 women (18–44 years) were recruited through schools and churches, respectively. Urinary iodine (UIC) and urinary creatinine (UCC) concentrations were measured in spot samples, and thyroglobulin (Tg) on dried blood spots. Their iodine intake was estimated, and dietary information collected. The median (IQR) UIC in SAC was 130 µg/L (79–204, n = 399), and in WRA, 115 µg/L (73–173, n = 322). The median (IQR) Tg in SAC was 19.7 µg/L (14.0–27.6, n = 370), and in WRA, 12.2 µg/L (7.9–19.0, n = 183); 10% of SAC had Tg > 40 µg/L. Estimated iodine intake was 77 µg/day and 202 µg/day in SAC and WRA, respectively. Iodized table salt was rarely consumed, though bouillon was used daily; this is hypothesized to be a major contributor to dietary iodine intake. Iodine intake in this remote region seems to have improved considerably since the 2018 national survey, though SAC remain at risk. These results point to the potential effectiveness of using social business principles to deliver humanitarian solutions.
Maternal Over- and Malnutrition and Increased Risk for Addictive and Eating Disorders in the Offspring
Authors: Guillaumin Mathilde C. C. , Peleg-Raibstein Daria
Published: February 2023

Evidence from human and animal studies has shown that maternal overnutrition and/or obesity are linked with neurobehavioral changes in the offspring. This fetal programming is characterized by adaptive responses to changes in the nutritional state during early life. In the past decade, an association has been made between overconsumption of highly-palatable food by the mother during fetal development and abnormal behaviors resembling addiction in the offspring. Maternal overnutrition can lead to alterations in the offspring’s brain reward circuitry leading to hyperresponsiveness of this circuit following exposure to calorie-dense foods later in life. Given the accumulating evidence indicating that the central nervous system plays a pivotal role in regulating food intake, energy balance, and the motivation to seek food, a dysfunction in the reward circuitry may contribute to the addiction-like behaviors observed in the offspring. However, the underlying mechanisms leading to these alterations in the reward circuitry during fetal development and their relevance to the increased risk for the offspring to later develop addictive-like behaviors is still unclear. Here, we review the most relevant scientific reports about the impact of food overconsumption during fetal development and its effect on addictive-like behaviors of the offspring in the context of eating disorders and obesity.