bluuebunny/crossref_metadata_2025 huggingface dataset:
Enoturismo e Vindimas no Terroir Vinhos de Altitude de Santa Catarina – Brasil
Authors: Ferri Gil Karlos , Nodari Eunice
Published: April 2023

Este artigo  discute sob o viés da história ambiental o enoturismo e a realização de vindimas que estão ocorrendo  no século XXI no terroir Vinhos de Altitude, localizado na região do Planalto do estado de Santa Catarina, Brasil. Através de revisão da bibliografia tanto teórica quanto  empírica, assim como aanálise de fontes sobre o tema – como matérias publicadas na imprensa, fotografias e material de marketing, sobretudo acerca da festa denominada “Vindima de Altitude” –, este trabalho busca ampliar o debate sobre o enoturismo. Entende-se um enoturismo que vai  além da idealização e romantização do setor, buscando um diálogo entre pesquisadores de diversas áreas do conhecimento e reflexões críticas no campo das ciências humanas. Argumentamos que a grande oportunidade para a construção de um diferencial para o terroir Vinhos de Altitude passa pela inserção de práticas sustentáveis nos vinhedos e a responsabilidade socioambiental para com os habitantes e o meio ambiente da região.
Association between Breastfeeding and Reduced Risk of Obesity in Childhood: A Cross-sectional Study in Ecuadorian Infants under Five Years of Age
Authors: Ponce-Alencastro Jhon , Chilito-Osorio Viviana , Ramos-Rivera Pamela , Tenorio-Romero Amanda , Castro-López Edison , Viña-Zambrano Karen , Cruz-Pierard Stephanie
Published: April 2023

Poor eating habits and an increased sedentary lifestyle are responsible for obesity being one of the main public health problems in Ecuador and the world. Several factors can modulate the risk of an infant to be obese, considering genetic, environmental and sociodemographic variables. The aim of this study is to analyze the evidence on the relationship between breastfeeding (BF) and obesity in childhood and thus contribute to the planning of prevention strategies from an early age. A nationally representative sample of children under 5 years of age from the National Health and Nutrition Survey (ENSANUT, 2018) was used. We used heteroscedasticity and autocorrelation tests of the data to rule out possible statistical modeling problems and used multicollinearity tests to avoid redundant information in the models. We also calculated confusion matrices to test the correct specification of the models. In addition, we used a binary logistic linear regression model where the Odds Ratio (OR) with their 95% confidence intervals (95% CI) were estimated for each of the independent variables. Our results show that those children who were breastfed show a greater protective factor against obesity compared to those children who were not breastfed. That is, our results show that exclusive breastfeeding during the first six months of life increased 2 times (OR= 2.01; CI=1.91-2.17) the probability of not suffering from obesity. Other significant protective factors are the mother's age, the mother's educational level and the mother's area of residence. The recommendation derived from this research is that BF should be carried out until the sixth month of life of the infant and complemented with solid (non-milk) food until two years of age and beyond since this could protect against childhood obesity and its associated comorbidities in adulthood, although the benefit that BF can offer against the risk of obesity in the general population is small.
Edukasi Kesehatan Masyarakat melalui Pelabelan pada Tanaman Obat dan Keluarga (TOGA) Di Desa Pagarawan
Authors: Wahyuni Winda , Khodijah Nyayu Siti , Faradiba Faradiba , Minawati Minawati , Santi Ratna , Aquarina Ririn
Published: April 2023

Perkembangan teknologi telah mengalami banyak kemajuan salah satunya yaitu dengan pengolahan senyawa kimia menjadi obat-obatan yang dapat menyembuhkan berbagai penyakit. Namun, penggunaan obat-obatan kimia dianggap dapat memberikan efek samping untuk kesehatan sehingga masyarakat beralih kepada obat herbal yang lebih alami dan dam minim efek samping seperti penggunaan tanaman obat keluarga (TOGA). Desa Pagarawan merupakan salah satu desa yang berpotensi besar untuk dikembangakan sebagai desa penghasil tanaman obat keluarga (TOGA). Permasalahan utama yang dihadapi oleh masyarakat Desa Pagarawan Kecamatan Merawang Kabupaten Bangka adalah kurangnya pengetahuan masyarakat mengenai jenis tanaman yang berkhasiat sebagai obat. Oleh sebab itu, perlu diberikan edukasi melalui pengenalan dan pemanfaatan pekarangan rumah untuk TOGA dan Pelabelan TOGA. Tanaman obat keluarga (TOGA) adalah tanaman yang memiliki manfaat dan khasiat yang baik untuk kesehatan dan ditanam di pekarangan untuk memenuhi kebutuhan obat keluarga. Tujuan dari kegiatan ini adalah untuk memberikan edukasi dan pemahaman kepada masyarakat tentang pemanfaatan lahan pekarangan sebagai tempat untuk penanaman TOGA dalam rangka penyediaan obat herbal keluarga. Kegiatan ini dilaksanakan pada tanggal 16 Agustus 2021 sampai dengan 25 Oktober 2021 berlokasi di Desa Pagarawan Kecamatan Merawang, Kabupaten Bangka. Kegiatan pengabdian ini melibatkan berbagai pihak diantaranya yaitu Pegawai Kantor Desa Pagarawan Kecamatan Merawang Kabupaten Bangka, masyarakat dan mahasiswa KKN. Kegiatan dimulai dengan pemanfaatan lahan kosong pekarangan yang berlokasi di belakang Kantor Desa Pagarawan. Hal ini disebabkan karena Kantor Desa merupakan salah satu pusat pelayanan masyarakat, sehingga diharapkan dapat menjadi contoh bagi masyarakat setempat. Dengan tersedianya TOGA di Desa Pagarawan diharapkan dapat membantu masyarakat dalam memanfaatkan toga untuk kesehatan.
PENYULUHAN HUKUM TENTANG PERSOALAN KONTEMPORER MENGENAI PEMILIHAN KEPALA DESA (PILKADES) SERENTAK DI KECAMATAN SUNGAI SELAN
Authors: Agustian Rio Armanda
Published: April 2023

Kegiatan Penyuluhan Hukum dengan tema atau judul Pemilihan Kepala Desa (Pilkades) yang dilakukan secara serentak di 8 (delapan) desa di Kecamatan Sungai Selan, Kabupaten Bangka Tengah, Provinsi Kepulauan Bangka Belitung ini merupakan sebuah program dari Fakultas Hukum Universitas Bangka Belitung yang direncanakan dan dilaksanakan berdasarkan situasi dan kondisi dimana hal ini sangatlah penting dan bermanfaat khususnya bagi institusi yang haruslah berperan penting dalam memberikan saran dan masukan untuk masyarakat di Kecamatan Sungai Selan dalam bentuk kegiatan penyuluhan hukum yang bermanfaat dan berguna bagi masyarakat. Kecamatan Sungai Selan merupakan salah satu kecamatan yang di Kabupaten Bangka Tengah, yang secara umum Kecamatan ini memiliki luas wilayah yaitu 789,74 KM Persegi yang terdiri dari 1 (satu) kelurahan yakni Kelurahan Sungai Selan dan 12 (dua belas) desa yakni Desa Tanjungpura, Desa Sungaiselan Atas, Desa Ramadhon, Desa Munggu, Desa Lampur, Desa Sarang Mandi, Desa Keretak, Desa Kerantai, Desa Kemingking, Desa Keretak Atas, Desa Kerakas, Desa Melabun. Untuk kelurahan saat ini dikepalai oleh seorang lurah yang diangkat oleh bupati, direkrut dari seorang Aparatur Sipil Negara (ASN). Untuk kelurahan di Kecamatan Sungai Selan ini belum memiliki hak otonom sebagaimana desa lainnya yang ada. Kelurahan adalah perangkat pemerintah daerah Kabupaten Bangka Tengah yang bertugas melaksanakan tugas/tufoksinya sebagai  pemerintahan yang dibebankan kepadanya. Sedangkan desa dikepalai oleh seorang kepala desa (kades) yang pengangkatannya dilakukan melalui pemilihan kepala desa (pilkades). Pilkades yang terjadi di desa sama halnya dengan pemilihan umum, namun hanya diwajibkan kepada seluruh warga desa yang bersangkutan atau yang berdomisili di desa tersebut, serta telah memenuhi syarat-syarat tertentu sesuai dengan peraturan perundang-undangan yang berlaku. Semenjak tahun 2020, di Kecamatan Sungai Selan terdapat 1 (satu) orang lurah yang ditunjuk atau ditugaskan untuk memperlancar proses kegiatan pemerintahan di tingkat kelurahan serta telah dibentuk struktur organisasi kelurahan agar  mempermudah dalam memberikan pelayanan bagi masyarakat.

Pelaksanaan penyuluhan hukum yang dilaksanakan di Kantor Kecamatan Sungai Selan ini  memiliki program kerja yakni dengan harapan dapat memberikan pemahaman bagi masyarakat seperti memahami dan mengerti terhadap berbagai hal-hal yang berkaitan dengan pemilihan kepala desa secara serentak di 8 (delapan) desa di Kecamatan Sungai Selan dengan tetap mengedepankan protokol keamanan Covid-19 sewaktu kegiatan berlangsung.
PENGEMBANGAN BUDIDAYA IKAN KETANG-KETANG (Scatophagus argus) DALAM UPAYA OPTIMALISASI PERAIRAN ESTUARI BAGI KELOMPOK PEMBUDIDAYA IKAN PEREPAT PERMAI KELURAHAN AIR JUKUNG, KECAMATAN BELINYU, KABUPATEN BANGKA
Authors: Utami Eva , Rendy Rendy , Nugraha Mohammad Agung
Published: April 2023

PENGEMBANGAN BUDIDAYA IKAN KETANG-KETANG (Scatophagus argus) DALAM UPAYA OPTIMALISASI PERAIRAN ESTUARI BAGI KELOMPOK PEMBUDIDAYA IKAN PEREPAT PERMAI KELURAHAN AIR JUKUNG, KECAMATAN BELINYU, KABUPATEN BANGKA
On the performance and impact of research in storytelling by Russia scholars
Authors: Arutyunov V. V.
Published: April 2023

The author analyzes the dynamics of scientometrical indicators (publication activity, citation and impact) of Russian research in storytelling in 2012–2021. Storytelling is seen as the marketing technology used to deliver information to the audience through stories. In recent years, storytelling has been intensively used in advertising, social media, corporate blogging, and in education. The lines of research of the greatest impact are identified, among them: storytelling as an efficient communication technology, digital storytelling in students’ projects, and storytelling method in corporate management. In accordance with the Hirsch index, the Russian scholars’ research activity in the field exceeds significantly the world minimum value of 16. The dynamics of the above indicators is revealed, including the rare occurrence of continuous growth in the number of publications by the end of the existent period; the organization which storytelling studies are extensively used by country’s other institutions, are identified, among them Nizhny Novgorod Kozma Minin Pedagogical University, Ural State Pedagogical University, RF Ministry for Civil Defense Academy of State Fire-fighting Service. The analysis was accomplished based on Russian Science Citation Index (RISC) database. The illustrations are included to visualize the research findings.
An approach for ranking abandoned mines by the efficient use of their geothermal potential
Authors: Rudakov D. V , Inkin O. V
Published: April 2023

Purpose. To develop an approach for ranking abandoned mines in terms of the efficiency of mine water heat recovery by geothermal systems through applying the set of basic criteria; they allow considering geological and mining conditions in first approximation and preliminary assessing the performance of the systems located on them. Methodology. The proposed approach includes the ranking of mines by five basic indicators usually available or easily calculated such as the conversion factor of heat pumps COP, energy balance, thermal capacity, profit of operation, and reduction of CO2 emissions. The energy balance introduced by the authors earlier is defined as the relation of thermal energy produced to the thermal equivalent of electricity required for operation. These indicators are integrated in the complex rank to compare the expected performance and generate the priority lists for industrial installations in mines. Findings. We ranked 27 abandoned coal mines in Donbas with available data by five indicators separately and the complex parameter defined through averaging their contributions. The top promising sites for open non-circulation, circulation, and closed loop systems in terms of efficient heat recovery were identified. These sites refer to mostly deep mines in the central part of Donbas with the enhanced geothermal gradient over 0.03 °C/m. Originality. Firstly, an approach to evaluate the geothermal potential and ranking the mines regarding the efficiency of thermal energy use based on existing and introduced performance indicators has been substantiated and validated for a group of abandoned mines. The developed technique allows-analyz and preliminary quantify the feasibility of geothermal installations of different design. Practical value. The proposed approach for ranking post-mining sites enables generating the priority lists with regard to recovery of low-grade energy from mine water, thus, identifying the geothermal potential and most promising sites for further detailed feasibility studies and operation of geothermal systems of various types.
Efficiency and internationalization of mining and ­metallurgical groups of Ukraine
Authors: Vagonova O. G , Metelenko N. G , Shapurov O. O , Chornobayev V. V
Published: April 2023

Purpose. Development of a structural and systemic approach to determining the effectiveness of the functioning and internationalization of the country’s mining and metallurgical industrial groups and the formation of their possible development vectors. Methodology. The results of the presented scientific research were obtained using general and special methods of cognition: abstract-logical analysis, systematization and combination, method of theoretical generalization, method of dialectical cognition, deduction and induction, statistical analysis, econometric method of trend formation. Findings. Approaches to the determination of performance indicators and the level of internationalization of mining and metallurgical industrial groups, which were dynamically formed in the modern conditions of the functioning of multinational companies, were systematized. Principles of calculation, system of indicators of efficiency and level of internationalization, which were chosen to evaluate the leading mining and metallurgical industrial groups of Ukraine, and methodical approaches to the calculation of performance indicators and evaluation of the level of internationalization were substantiated, and analytical conclusions were formulated. The forecast was made and the development vectors of the country’s leading mining and metallurgical industrial groups were established based on the econometric calculations. Originality. Structural and systemic approach was justified to measuring the efficiency of operation and the level of internationalization of mining and metallurgical industrial groups of Ukraine, which is built on the principle of hierarchy, includes logically consecutive stages and provides an opportunity to determine the actual development vectors of mining and metallurgical industrial groups of Ukraine based on the econometric trend. A close relationship was established (on the basis of the calculation of the coefficient of determination) of performance indicators and the level of internationalization of mining and metallurgical industrial groups of Ukraine with the time factor. At the specification stage, trends (parabolic, logarithmic, hyperbolic, linear ones) were selected, their parameters were estimated by the method of least squares. The statistical significance of the equation was tested using the coefficient of determination and Fisher’s test. Practical value. It consists in the possibility of using the results of the conducted research for scientific developments and practical activities. The feasibility of systematic use of performance indicators and the level of internationalization in the practical activities of the leading mining and metallurgical industrial groups of Ukraine has been proven. The structural and systemic approach, which is built on the principle of hierarchy, provides an opportunity to determine the current development vectors of the leading mining and metallurgical industrial groups of Ukraine .
Hiệu ứng ngưỡng của thanh khoản thị trường chứng khoán đến tăng trưởng kinh tế
Authors: Bùi Ngọc Toản , Đoàn Thị Thu Trang
Published: April 2023

Bài nghiên cứu này được thực hiện nhằm phân tích tác động của thanh khoản thị trường chứng khoán đến tăng trưởng kinh tế. Mẫu dữ liệu được thu thập từ 5 quốc gia ASEAN, bao gồm Indonesia, Malaysia, Philippines, Thái Lan và Việt Nam, giai đoạn 2008-2020. Các tác giả sử dụng hiệu ứng ngưỡng để ước lượng giá trị ngưỡng của thanh khoản thị trường chứng khoán. Tiếp theo, các tác giả sử dụng phương pháp GMM (Generalized method of moments) để ước lượng tác động của thanh khoản thị trường chứng khoán đến tăng trưởng kinh tế ở các miền trước và sau giá trị ngưỡng này. Kết quả ước lượng cho thấy giá trị ngưỡng của thanh khoản thị trường chứng khoán là 21,243%. Tuy nhiên, tác động tích cực của thanh khoản thị trường chứng khoán đến tăng trưởng kinh tế chỉ có ý nghĩa thống kê ở miền sau giá trị ngưỡng. Những phát hiện này là bằng chứng thực nghiệm có ý nghĩa quan trọng đối với các quốc gia ASEAN, đặc biệt là trong việc quản lý thị trường chứng khoán nhằm thúc đẩy nền kinh tế.
PENERAPAN METODE ARIMA BOX-JENKINS UNTUK MEMPREDIKSI HARGA SAHAM DI PT ANEKA TAMBANG TBK
Authors: Triputra Ilham Yusuf , Sufri Sufri , Yurinanda Sherli
Published: April 2023

A capital market is a market in which long-term trading of financial assets takes place, or a market in which various financial instruments are traded. The development of capital markets promotes the economic development of the country. The form of investment in the capital market is in the form of shares. Because stock prices are constantly fluctuating, capital market participants need analysis to help predict future stock prices. PT Aneka Tambang TBK or ANTM for short is one of the stocks traded in Indonesia's capital market. This study applied the Box-Jenkins ARIMA method for the period from July 2021 to November 2021 to determine the optimal forecast model for stock price fluctuations of ANTM, and obtained forecast results in December 2021. It is intended to The best preserved model is his ARIMA model (3,2,0) and ANTM's December 2021 stock price forecast results are down.
ANALISIS PENYEBAB KECELAKAAN LALU LINTAS DI JALAN EMPUNALA KOTA MOJOKERTO
Authors: Zaini aryatama Fauzi
Published: April 2023

Kota Mojokerto merupakan kota industri yang menjadikan Mojokerto sebagai jalur penghubung transportasi antar kota yang padat akan kendaraan. Di jam sibuk ketika puncak jam berangkat dan pulang kerja lalu lintas di jalan raya Empunala sangat padat oleh karyawan dan buruh pabrik. Dengan meningkatnya aktiftas penggunaan jalan raya dapat berpotensi terjadi kecelakaan maka perlu adanya analisis penyebab dan penanggulangan untuk bisa mengurangi angka kecelakaan. Lokasi yang diambil yaitu Jalan Empunala dnegan pajang 4,2 km yaang dibagi menjadi 2 segmen ruas. Penelitian ini menggunakan metode deskriptif. Data yang diperlukan dalam penelitian ini adalah data primer berupa data survey, dan data skunder, yaitu data kecelakaan di jalan Empunala pada tahun 2018 – 2020, dan data volume lalu lintas. Hasil yang diperoleh dalam penelitian ini menunjukan bahwa jumlah tingkat kecelakaan di jalan Empunala pada tahun 2018, 2019, 2020 yaitu sebesar 28 kejadian kecelakaan, 18 kejadian kecelakaan dan 16 kejadian kecelakaan sdengan faktor penyebab tertinggi adalah faktor manusia yaitu 41 kecelakaan dengan presentase 66%, lalu faktor kendaraan sebesar 12 kecelakaan dengan presentase 19%, faktor jalan sebanayak 7 kecelakaan dengan presentase 11% dan terendah yaitu faktor lingkungan sebanyak 2 kecelakaan dengan presentase 3%.

 

Keywords : Penyebab Kecelakaan, Kecelakaan lalu lintas, Daerah rawan keceakaan, Faktor Manusia.
Dampak On-Street Parking Terhadap Kinerja Jalan
Authors: Paisal Poni , Matarru Alik , Primawati Eva Rizky , Yulianti Yulis , Akbar Muh
Published: April 2023

Merauke adalah kota paling timur Republik Indonesia, berbatasan langsung dengan Papua Nugini (PNG), tentunya daerah ini menarik untuk dikunjungi sebagai destinasi wisata lokal maupun manca negara  bagi para wisatawan. Kajian pada penelitian ini adalah pada ruas jalan Raya Mandala merupakan jalur yang berpotensi terjadi terjadi masalah kemacetan karena merupakan daerah komersial dan pusat perniagaan dan memiliki kegiatan on-street parking. Tujuan penelitian ini  adalah  untuk  menghitung  besarnya  penurunan  tingkat  kinerja  jalan  akibat  kegiatan  on-street parking.  Survey  dilakukan  selama  7  hari  yaitu  hari  senin s/d hari Minggu . Pengamatan  dilakukan  selama  12  jam  yaitu  pukul  07.00  –  13.00, 15.00 – 21.00 WIT.  Metode perhitungan menggunakan Manual Kapasitas Jalan Indonesia (MKJI) 1997. Penelitian  yang  dilakukan  di  jalan  Raya Mandala Kota Merauke  ini  meliputi  survey volume lalu lintas (Traffic Counting), yaitu mencacah semua jenis kendaraan yang melewati ruas  jalan  ini  meliputi  kendaraan  berat,  kendaraan  ringan,  motor  cycle  (sepeda  motor)  dan kendaraan  tidak  bermotor.  Survey  parkir  ,  yaitu  mengamati  dan  mencatat  jumlah  kendaraan keluar masuk on-street parking serta durasi waktu parkir. Hasil penelitian menunjukkan bahwa kegiatan on-street parking sangat berpengaruh terhadap  penurunan  kinerja  ruas  jalan  Raya Mandala Kota Merauke.  Besarnya  pengaruh penurunan kinerja jalan akibat kegiatan on-street parking untuk hari senin 0.21 hingga 0.26, selasa 0.22 hingga 0.25, rabu 0.23 hingga 0.22 kamis 0.20 hingga 0.26, jumat 0.23 hingga 0.29, sabtu  0.19 hingga 0.33, Pada hari Minggu terjadi penurunan kinerja jalan dari 0.17 hingga 0.28
2Rev_Rancang Bangun_Marwa+Teknik+Unismuh2
Authors: Unismuh Nurnawaty , Marwah ahmad  , Aswandi Ismail  , Fauzan Hamdi
Published: April 2023

Saluran peluncur pada bendungan membawa aliran dari ujung hilir saluran transisi sampai peredam energi. Kecepatan aliran yang tinggi dan tekanan yang rendah pada saluran peluncur dapat menimbulkan kavitasi dan aliran getar. Pelimpah memiliki kemiringan curam berisiko terhadap munculnya perilaku hidraulika yaitu kavitasi, kavitasi yang tidak dihilangkan dapat membahayakan permukaan dasar saluran akibat terjadinya gerusan. Tujuan penelitian ini untuk mengetahui nilai indeks kavitasi dan klasifikasi nilai indeks kavitasi. Metode penelitian ini digunakan jenis penelitian deskriptif kuantitatif menggunakan analisis data sekunder sebagai sumber data utama, dengan cara perbandingan menggunakan data lapangan dengan pemodelan aplikasi HEC-RAS. Hasil nilai indeks kavitasi yang terjadi disaluran peluncur bervariasi setiap bulannya dipengaruhi oleh debit, kecepatan, kedalaman air dan temperatur, dengan cara manual nilai indeks kavitasi terbesar 180,70 terjadi pada bulan Maret debit q5 dan terkecil 4,54 terjadi pada bulan Februari pada debit q350, Untuk cara komputasi nilai indeks kavitasi terbesar 249,42 pada bulan Januari debit Q5, dan terkecil 8,74 pada bulan Februari debit Q350, dan Klasifikasi nilai indeks kavitasi diperoleh bahwa nilai indeks kavitasi lebih besar dari 1 (σ>1) masuk dalam level 1 yang berarti bahwa tidak terjadi aliran negatif atau saluran peluncur masuk dalam kategori aman terhadap kavitasi. 

Saluran peluncur pada bendungan membawa aliran dari ujung hilir saluran transisi sampai peredam energi. Kecepatan aliran yang tinggi dan tekanan yang rendah pada saluran peluncur dapat menimbulkan kavitasi dan aliran getar. Pelimpah memiliki kemiringan curam berisiko terhadap munculnya perilaku hidraulika yaitu kavitasi, kavitasi yang tidak dihilangkan dapat membahayakan permukaan dasar saluran akibat terjadinya gerusan. Tujuan penelitian ini untuk mengetahui nilai indeks kavitasi dan klasifikasi nilai indeks kavitasi. Metode penelitian ini digunakan jenis penelitian deskriptif kuantitatif menggunakan analisis data sekunder sebagai sumber data utama, dengan cara perbandingan menggunakan data lapangan dengan pemodelan aplikasi HEC-RAS. Hasil nilai indeks kavitasi yang terjadi disaluran peluncur bervariasi setiap bulannya dipengaruhi oleh debit, kecepatan, kedalaman air dan temperatur, dengan cara manual nilai indeks kavitasi terbesar 180,70 terjadi pada bulan Maret debit q5 dan terkecil 4,54 terjadi pada bulan Februari pada debit q350, Untuk cara komputasi nilai indeks kavitasi terbesar 249,42 pada bulan Januari debit Q5, dan terkecil 8,74 pada bulan Februari debit Q350, dan Klasifikasi nilai indeks kavitasi diperoleh bahwa nilai indeks kavitasi lebih besar dari 1 (σ>1) masuk dalam level 1 yang berarti bahwa tidak terjadi aliran negatif atau saluran peluncur masuk dalam kategori aman terhadap kavitasi.
Osmanlı Devleti’nde Coğrafya ve Mali Kapasite
Authors: YILDIRIM Sadullah
Published: April 2023

Bu çalışma mali kapasite ile coğrafya arasındaki ilişkiyi Osmanlı Devleti özelinde incelemektedir. Vergi elde etme sürecinde ortaya çıkabilecek işlem maliyetleri üzerinden geliştirilen teorik çerçeve ışığında, merkezi devletin erişiminin zor olduğu yerlerdeki vergi tabanlarının tımar kesimine, buna karşın kolay olduğu yerlerdeki vergi tabanlarının ise merkezi devlete ayrılması gerektiği çıkarsanmıştır. Bu hipotezi test etmek için ise kaza düzeyinde gelirlerin merkez, tımar ve vakıf-mülk arasında nasıl pay edildiği bilgisini içeren 1530 yılı muhasebe defterleri ile işlem maliyetlerini yansıtma potansiyeline sahip coğrafi değişkenler olan yükselti, orman yoğunluğu, nehre mesafe yağış, sıcaklık, toprağın tarıma elverişliliği, enlem, İstanbul’a, ticaret yollarına, ana yollara ve askeri yollara olan mesafe değişkenleri kullanılmıştır. Analiz sonuçları yükselti ve orman yoğunluğu değişkeninin tımara giden payı artırırken merkezi devlete giden payı azalttığını göstermektedir.
Bununla birlikte İstanbul’a olan mesafe arttıkça ilginç bir şekilde merkeze ayrılan payın arttığı ama vakıf-mülk kesimine ayrılan oransal payın ise azaldığı görülmektedir. İstanbul’a olan mesafe ile tımara ayırılan pay arasında istatistiki olarak anlamlı bir ilişki bulunamamıştır.
Cisterna Magna Injection Mouse Model of Subarachnoid Hemorrhage (SAH): A Systematic Literature Review of Preclinical SAH Research
Authors: Alpdogan Serdar , Li Ke , Sander Timo , Cornelius Jan Frederick , Muhammad Sajjad
Published: April 2023

Objective: This review article describes the characteristics of published literature using the cisterna magna blood injection mouse model of subarachnoid hemorrhage (SAH) with the aim to define particular standards and identify moderators of mortality rate, SAH grade, and large artery vasospasm.

Methods: We searched for English-original peer-reviewed studies which reported the induction of SAH in mice via single or multiple blood injections into the cisterna magna. The search included studies published until 13th February 2023 on PubMed, Embase and Web of Science. Furthermore, we investigated the reporting of mortality rate, vasospasms by measuring large arteries, and SAH grade in cisterna magna blood injection mouse model.

Results: Seven articles out of 136 identified records matched our inclusion criteria and were therefore included in descriptive analysis. Four articles reported the mortality rate which varied between zero and 22 percent. Five articles displayed vasospasms of large cerebral arteries including basilar artery (BA), anterior cerebral artery (ACA), and middle cerebral artery (MCA). Interestingly, the diameters of the observed arteries started to decrease already within the first hour after blood injection and achieved the lowest values at different times, but mainly between six and twelve hours after SAH induction. The artery diameters reached nearly their pre-SAH (control group) diameters approximately after four to seven days after SAH. However, the SAH severity grade was reported in none of these publications. No uniform model characteristics were observed in current literature.

Conclusion: A systemic overview of the cisterna magna blood injection mouse model of SAH is presented. An important heterogeneity was observed. Hence, standardized model features and study endpoints have to be defined in order to improve reporting frequency and quality to enhance the reproducibility of preclinical SAH research in the future.
MATLAB PROGRAM FOR RATING SOILS BASED ON ENGINEERING BEHAVIOURS
Authors: Ekeoma Emmanuel Chukwudi , Okonkwo Ugochukwu Nnatuanya , Odumade Adegboyega Oduniyi
Published: April 2023

Engineering behaviour of soils is an important attribute to be considered as the foundation or even construction materials for civil engineering structures. One critical issue encountered by geotechnical engineers in construction works is predicting the engineering behaviour of soil with a view to assessing its suitability for any given construction purpose. Rating of soils based on their engineering behaviours can be achieved by classifying the soil into different groups and sub-groups of similar characteristics. Soil classification systems usually involve the use of charts, tables and curves, which is no longer fashionable because it might be very rigorous when many soils are involved. The use of software techniques simplifies the whole process. This study developed an algorithm in the form of a MATLAB program for easy classification of soil based on the Unified Soil Classification System (USCS), American Association of State Highway and Transport Officials (AASHTO), Plasticity Chart and the Indian Soil Classification Systems (ISCS), which makes the program unique. Soil samples used for illustration were collected and characterised depending on particle size analysis as well as consistency indices. A comparative study was carried out between classifying the soil using a manual approach and the MATLAB program. The MATLAB program rated Soil Sample A to be fine-grained, which belongs to soil groups A-7-6(15), CL (inorganic clay that has medium plasticity) and MI or OI (inorganic silt of medium plasticity or organic silt of medium plasticity) while Soil Sample B was rated to be coarse-grained belonging to A-1-b (0), SM (Silty Sand) and SM (Silty Sand) in the AASHTO, USCS and ISCS classification systems respectively. The results of the classification systems from the MATLAB program were completely in conformity with the results obtained from the manual approach. Thus, the MATLAB program gave a very high degree of accuracy of almost 100%.
The Capacity Efficiency Of Production Machinery And Raw Material Supply Control : Production Process In "Galvanized Steel" Company, Bekasi City
Authors: Wartini Wartini , Wibowo Martino
Published: April 2023

To produce a product that is of good quality with a smooth production process, it is necessary to establish a system of Machine Efficiency Capacity and Raw Material Supplies appropriately, this is intended to make it easier for companies to meet the required quantity of production and efficiency efficiently and certainly affect the smooth production. The purpose of this research is to find out and analyze the Effect of Capacity of Machine Efficiency in Production and Inventory Control of Raw Materials on the Smooth Production Process in Bekasi Branch "Galvanized Steel" Company. The type of research used is observation with a multiple linear regression analysis model with 32 samples. The regression test results show that 58.5%, the smoothness of the production process can be explained by the capacity of machine efficiency, and control of inventory of raw materials, while the remaining 41.5% is explained by other factors not examined in this study. F test results show that simultaneously the efficiency of production machinery and raw material inventory control have a significant effect on the smooth production process. The results of the t test show partially the capacity of machine efficiency has a significant effect on the smoothness of the production process while the control variables for raw material inventory have no significant effect on the smooth production process in the branch company "GALVANIZED STEEL" Bekasi
Effect of Hot Pack Administration on Shivering in Post Sectio Caesarea Patients with Spinal Anesthesia
Authors: Prameswari Diah , Septya Intan Eka , Shahab Davis Achmadi , Novita Ita , Ratnasari Dezylia Ayu , Mulyati Wiwin
Published: April 2023

The use of anesthetic techniques is an option for patients with sectio caesarea because the patient is conscious and the recovery period is faster. The impact that often arises after spinal anesthesia is shivering. This study aims to determine the effect of hot packs on shivering in post-cesarean section patients with spinal anesthesia. The research design is a Quasi Experiment with a pre-test post-test control group design. The independent variable of this study is giving hot packs and the dependent variable is shivering. This research was conducted in the High Care Unit Room (HCU) of Aminah Islamic Hospital Blitar from 6 to 31 January 2020. The samples obtained were 32 respondents, 16 respondents in the treatment group and 16 respondents in the control group using accidental sampling. The results showed that the majority of respondents in the treatment and control groups experienced a shivering scale of 2 before administering the hot pack. After administration of the shivering scale hot packs in the treatment group experienced a significant decrease to 0 while the control group experienced a not very significant decrease in shivering scale, namely to 1. Statistical test This study uses Mann Whitney with a p-value of 0.000. This means that giving hot packs has an effect on shivering in post sectio caesarea patients with spinal anesthesia. After administration of hot packs, the shivering scale in the treatment group experienced a significant decrease to 0, while in the control group, the shivering scale decreased which was not too significant, namely to 1. The statistical test of this study used Mann Whitney with a p-value of 0.000. This means that giving hot packs has an effect on shivering in post sectio caesarea patients with spinal anesthesia. After administration of hot packs, the shivering scale in the treatment group experienced a significant decrease to 0, while in the control group, the shivering scale decreased which was not too significant, namely to 1. The statistical test of this study used Mann Whitney with a p-value of 0.000. This means that giving hot packs has an effect on shivering in post sectio caesarea patients with spinal anesthesia.
Effects of second-line anti-tuberculosis drugs on the intestinal microbiota of patients with rifampicin-resistant tuberculosis
Authors: Wu Chunli , Yi Hengzhong , Hu Yanmei , Luo Danlin , Tang Zhigang , Wen Xinmin , Zhang Yong , Tang Mi , Zhang Lizhi , Wu Shu , Chen Mengshi
Published: April 2023

Objective

To determine the effects of second-line anti-tuberculosis (TB) drugs on the composition and functions of intestinal microbiota in patients with rifampicin-resistant TB (RR-TB).

Methods

In this cross-sectional study, stool samples and relevant clinical information were collected from patients with RR-TB admitted to the Drug-resistant Specialty Department at Hunan Chest Hospital (Hunan Institute For Tuberculosis Control). The composition and functions of intestinal microbiota were analyzed using metagenomic sequencing and bioinformatics methods.

Results

Altered structural composition of the intestinal microbiota was found when patients from the control, intensive phase treatment, and continuation phase treatment groups were compared (P<0.05). Second-line anti-TB treatment resulted in a decrease in the relative abundance of species, such as Prevotella copri, compared with control treatment. However, the relative abundance of Escherichia coli, Salmonella enterica, and 11 other conditionally pathogenic species increased significantly in the intensive phase treatment group. Based on differential functional analysis, some metabolism-related functions, such as the biosynthesises of phenylalanine, tyrosine, and tryptophan, were significantly inhibited during second-line anti-TB drug treatment, while other functions, such as phenylalanine metabolism, were significantly promoted during the intensive phase of treatment.

Conclusion

Second-line anti-TB drug treatment caused changes in the structural composition of the intestinal microbiota in patients with RR-TB. In particular, this treatment induced a significant increase in the relative abundance of 11 conditionally pathogenic species, including Escherichia coli. Functional analysis revealed significantly decreased biosynthesises of phenylalanine, tyrosine, and tryptophan and significantly increased phenylalanine metabolism.
Application of DNA molecules in nature- inspired technologies: a mini review
Authors: Semchenko Igor V. , Khakhomov Sergei A.
Published: April 2023

The DNA molecule is considered as an object of nature-like technologies, with the focus on the special electromagnetic properties of DNA-like helices. This is the difference from the traditional approach to the DNA molecule as the repository of genetic information. DNA-like helices are regarded as artificial micro-resonators, or “meta-atoms,” exhibiting both dielectric and magnetic properties, that are equally pronounced. The article presents methods for creating spatial structures directly from DNA molecules, as well as from DNA-like helices. It is shown that the design of metamaterials and metasurfaces should be carried out considering the special electromagnetic properties of DNA-like helices. This will make it possible to obtain the required properties of metamaterials and metasurfaces and achieve advantages over other types of artificial structures.
Striatal spatial heterogeneity, clustering, and white matter association of GFAP+ astrocytes in a mouse model of Huntington’s disease
Authors: Brown Taylor G. , Thayer Mackenzie N. , VanTreeck Jillian G. , Zarate Nicole , Hart Damyan W. , Heilbronner Sarah , Gomez-Pastor Rocio
Published: April 2023

Introduction

Huntington’s disease (HD) is a neurodegenerative disease that primarily affects the striatum, a brain region that controls movement and some forms of cognition. Neuronal dysfunction and loss in HD is accompanied by increased astrocyte density and astrocyte pathology. Astrocytes are a heterogeneous population classified into multiple subtypes depending on the expression of different gene markers. Studying whether mutant Huntingtin (HTT) alters specific subtypes of astrocytes is necessary to understand their relative contribution to HD.

Methods

Here, we studied whether astrocytes expressing two different markers; glial fibrillary acidic protein (GFAP), associated with astrocyte activation, and S100 calcium-binding protein B (S100B), a marker of matured astrocytes and inflammation, were differentially altered in HD.

Results

First, we found three distinct populations in the striatum of WT and symptomatic zQ175 mice: GFAP+, S100B+, and dual GFAP+S100B+. The number of GFAP+ and S100B+ astrocytes throughout the striatum was increased in HD mice compared to WT, coinciding with an increase in HTT aggregation. Overlap between GFAP and S100B staining was expected, but dual GFAP+S100B+ astrocytes only accounted for less than 10% of all tested astrocytes and the number of GFAP+S100B+ astrocytes did not differ between WT and HD, suggesting that GFAP+ astrocytes and S100B+ astrocytes are distinct types of astrocytes. Interestingly, a spatial characterization of these astrocyte subtypes in HD mice showed that while S100B+ were homogeneously distributed throughout the striatum, GFAP+ preferentially accumulated in “patches” in the dorsomedial (dm) striatum, a region associated with goal-directed behaviors. In addition, GFAP+ astrocytes in the dm striatum of zQ175 mice showed increased clustering and association with white matter fascicles and were preferentially located in areas with low HTT aggregate load.

Discussion

In summary, we showed that GFAP+ and S100B+ astrocyte subtypes are distinctly affected in HD and exist in distinct spatial arrangements that may offer new insights to the function of these specific astrocytes subtypes and their potential implications in HD pathology.
Integration of optic flow into the sky compass network in the brain of the desert locust
Authors: Zittrell Frederick , Pabst Kathrin , Carlomagno Elena , Rosner Ronny , Pegel Uta , Endres Dominik M. , Homberg Uwe
Published: April 2023

Flexible orientation through any environment requires a sense of current relative heading that is updated based on self-motion. Global external cues originating from the sky or the earth‘s magnetic field and local cues provide a reference frame for the sense of direction. Locally, optic flow may inform about turning maneuvers, travel speed and covered distance. The central complex in the insect brain is associated with orientation behavior and largely acts as a navigation center. Visual information from global celestial cues and local landmarks are integrated in the central complex to form an internal representation of current heading. However, it is less clear how optic flow is integrated into the central-complex network. We recorded intracellularly from neurons in the locust central complex while presenting lateral grating patterns that simulated translational and rotational motion to identify these sites of integration. Certain types of central-complex neurons were sensitive to optic-flow stimulation independent of the type and direction of simulated motion. Columnar neurons innervating the noduli, paired central-complex substructures, were tuned to the direction of simulated horizontal turns. Modeling the connectivity of these neurons with a system of proposed compass neurons can account for rotation-direction specific shifts in the activity profile in the central complex corresponding to turn direction. Our model is similar but not identical to the mechanisms proposed for angular velocity integration in the navigation compass of the fly Drosophila.
Amyloid and tau PET in cerebral amyloid angiopathy-related inflammation two case reports and literature review
Authors: Yang Jhih-Yong , Chu Yung-Tsai , Tsai Hsin-Hsi , Jeng Jiann-Shing
Published: April 2023

Background

Cerebral amyloid angiopathy-related inflammation (CAA-ri) is a clinical syndrome characterized by MRI findings of amyloid-related imaging abnormalities-edema (ARIA-E) suggestive of autoimmune and inflammatory reaction and hemorrhagic evidence of cerebral amyloid angiopathy. The longitudinal variation of amyloid PET and its imaging association with CAA-ri are undetermined. Moreover, tau PET in CAA-ri has been rarely investigated.

Method

We retrospectively described two cases of CAA-ri. We provided the temporal change of amyloid and tau PET in the first case, and the cross-sectional finding of amyloid and tau PET in the second case. We also performed a literature review of the imaging features of amyloid PET in reported cases of CAA-ri.

Results

In the first case, an 88-year-old male presented with progressive consciousness and gait disturbances over 2 months. MRI showed disseminated cortical superficial siderosis. Amyloid PET prior to and after the CAA-ri revealed focally decreased amyloid load in the region of ARIA-E. In the second case, a 72-year-old male was initially suspected to have central nervous system cryptococcosis but later diagnosed with CAA-ri because of the characteristic MRI features and good response to corticosteroid treatment; a subsequent amyloid scan revealed positive amyloid deposition of the brain. Neither case suggested an association between the region of ARIA-E and higher amyloid uptake on PET before or after onset of CAA-ri. Our literature review revealed variable findings related to amyloid burden in post-inflammatory regions in previously reported CAA-ri cases with available amyloid PET. Our case is the first report of longitudinal changes on amyloid PET and show focal decreases in amyloid load after the inflammatory process.

Conclusion

This case series highlights the need to better explore the potential of longitudinal amyloid PET in the understanding of the mechanisms of CAA-ri.
Case Report: Identification of a novel NTRK3-AJUBA fusion co-existing with ETV6-NTRK3 fusion in papillary thyroid carcinoma
Authors: Yu Qing-Xiang , Zhao Wen-Jun , Wang He-Yue , Zhang Lei , Qin Lan , Zhang Lei , Han Jian-li
Published: April 2023

NTRK fusions are validated oncogenic drivers of various adult and pediatric tumor types, including thyroid cancer, and serve as a therapeutic target. Recently, tropomyosin receptor kinase (TRK) inhibitors, such as entrectinib and larotrectinib, display promising therapeutic efficacy in NTRK-positive solid tumors. Although some NTRK fusion partners have been identified in thyroid cancer, the spectrum of NTRK fusion is not fully characterized. In this study, a dual NTRK3 fusion was identified by targeted RNA-Seq in a 47-year-old female patient with papillary thyroid carcinoma. The patient harbors a novel in-frame fusion between NTRK3 exon 13 and AJUBA exon 2, co-existing with a known in-frame fusion between ETV6 exon 4 and NTRK3 exon 14. The dual NTRK3 fusion was validated by Sanger sequencing and fluorescence in situ hybridization (FISH) but lack TRK protein expression as defined by pan-TRK immunohistochemistry (IHC). We supposed the pan-TRK IHC result to be falsely negative. In conclusion, we present the first case of a novel NTRK3-AJUBA fusion co-existing with a known ETV6-NTRK3 fusion in thyroid cancer. These findings extend the spectrum of translocation partners in NTRK3 fusion, and the effect of dual NTRK3 fusion on TRK inhibitor therapy and prognosis needs long-term follow-up.
Case Report: Long-term complete response to PSMA-targeted radioligand therapy and abiraterone in a metastatic prostate cancer patient
Authors: Parker David , Zambelli Jessica , Lara Montana Kay , Wolf Trevor Hamilton , McDonald Amber , Lee Erica , Abou-Elkacem Lotfi , Gordon Eva J. , Baum Richard P.
Published: April 2023

Despite decades of research and clinical trials, metastatic castration-resistant prostate cancer (mCRPC) remains incurable and typically fatal. Current treatments may provide modest increases in progression-free survival but can come with significant adverse effects and are disaggregated from the diagnostic imaging needed to fully assess the spread of metastatic disease. A theranostic approach, using radiolabeled ligands that target the cell surface protein PSMA, simplifies the visualization and disease treatment process by enabling both to use similar agents. Here, we describe an exemplary case wherein a gentleman in his 70s with mCRPC on diagnosis was treated with 177Lu–PSMA-617 and abiraterone, and remains disease-free to date, over five years later.
Radiation therapy attenuates lymphatic vessel repair by reducing VEGFR-3 signalling
Authors: Pillay Vinochani , Shukla Lipi , Herle Prad , Maciburko Simon , Bandara Nadeeka , Reid Isabella , Morgan Steven , Yuan Yinan , Luu Jennii , Cowley Karla J. , Ramm Susanne , Simpson Kaylene J. , Achen Marc G. , Stacker Steven A. , Shayan Ramin , Karnezis Tara
Published: April 2023

Introduction: Surgery and radiotherapy are key cancer treatments and the leading causes of damage to the lymphatics, a vascular network critical to fluid homeostasis and immunity. The clinical manifestation of this damage constitutes a devastating side-effect of cancer treatment, known as lymphoedema. Lymphoedema is a chronic condition evolving from the accumulation of interstitial fluid due to impaired drainage via the lymphatics and is recognised to contribute significant morbidity to patients who survive their cancer. Nevertheless, the molecular mechanisms underlying the damage inflicted on lymphatic vessels, and particularly the lymphatic endothelial cells (LEC) that constitute them, by these treatment modalities, remain poorly understood.

Methods: We used a combination of cell based assays, biochemistry and animal models of lymphatic injury to examine the molecular mechanisms behind LEC injury and the subsequent effects on lymphatic vessels, particularly the role of the VEGF-C/VEGF-D/VEGFR-3 lymphangiogenic signalling pathway, in lymphatic injury underpinning the development of lymphoedema.

Results: We demonstrate that radiotherapy selectively impairs key LEC functions needed for new lymphatic vessel growth (lymphangiogenesis). This effect is mediated by attenuation of VEGFR-3 signalling and downstream signalling cascades. VEGFR-3 protein levels were downregulated in LEC that were exposed to radiation, and LEC were therefore selectively less responsive to VEGF-C and VEGF-D. These findings were validated in our animal models of radiation and surgical injury.

Discussion: Our data provide mechanistic insight into injury sustained by LEC and lymphatics during surgical and radiotherapy cancer treatments and underscore the need for alternative non-VEGF-C/VEGFR-3-based therapies to treat lymphoedema.