bluuebunny/crossref_metadata_2025 huggingface dataset:
Examining Sepsis Incidence, Risk Factors, and Mitigation Efforts at PKU Muhammadiyah Gamping Hospital, Yogyakarta: A Retrospective Analysis
Authors: Kusbaryanto  , Gobel Fatmah Afrianty , Listiowati Ekorini , Rosyida Aisyah
Published: September 2024

Sepsis poses a significant challenge in healthcare settings due to its association with heightened morbidity and mortality rates, prolonged hospitalizations, and increased healthcare expenditures. This study aims to investigate the incidence of sepsis, its associated risk factors, and the efficacy of various mitigation efforts implemented at PKU Muhammadiyah Gamping Hospital in Yogyakarta. Employing a cross-sectional, analytical observational design, this study examined a sample comprising patients diagnosed with sepsis at the hospital between January 2019 and December 2022, meeting predefined inclusion and exclusion criteria. Inclusion criteria encompassed patients diagnosed with sepsis in accordance with hospital protocols and those admitted between January 2019 and December 31, 2022, while exclusion criteria included patients with incomplete bacteremia diagnoses. Consecutive sampling was utilized for sample selection, with data extracted from patient records maintained in the hospital's medical archives. This study was conducted with the approval of PKU Muhammadiyah Gamping Hospital's ethical committee (permit number: 051/KEP-PKU/III/2023). Analysis of four years' worth of data revealed a total of 210 cases of sepsis, comprising 112 male and 98 female patients.
Development and Analysis of a Web-Based Management Information System for Dental Practices to Improve Healthcare Services
Authors: Wardhana Erdianto Setya , Rahman Erwid Fatchur , Christiono Sandy , Hadianto Eko , Firdausy Muhammad Dian , Failasufa Hayyu , Firdhausa Madania
Published: September 2024

Introduction: A website-based management information system is needed in dental practices as a public service center that is required to work quickly, precisely, and accurately. The performance of dental practices becomes more optimal with a computerized management information system.
Objectives: This study aimed to develop and analyze a web-based management information system for dental practices to improve healthcare services in Indonesia.
Methods: This is an action research design conducted at an independent dental practice in Kudus, Indonesia. The research utilized the waterfall method, which started with requirements analysis, design, implementation, testing, and deployment, as well as maintenance. The analysis was carried out using two methods: Black-Box Testing and User Acceptance Testing (UAT). The UAT percentage results were categorized into 5 sections: 0%-20% very unsatisfied, 21%-40% unsatisfied, 41%-60% neutral, 61%-80% satisfied, and 81%-100% very satisfied.
Results: Testing used the Black-Box Testing method on 17 menus, with results meeting the expected specifications and no errors detected during the testing. The User Acceptance Testing (UAT) indicated a 96% approval rate, which signified an excellent rating in users' assessment of the developed system.
Conclusions: Based on the results of the study, a web-based electronic dental practice management information system was proposed to meet the needs of dentists.
Educational Effect of Practical Examination on Basic Cardiopulmonary Resuscitation Self-Learning
Authors: Uhm Tai-Hwan , Park Sang-Kyu , Kim Jee Hee
Published: September 2024

Simplification of basic cardiopulmonary resuscitation (CPR) enables easy production of videos for training, and non-face-to-face training can be provided via internet. The participants of this study were 89 university students   who took basic CPR class in 2020. We utilized teaching materials that is a 50-minute teaching material for standard adult CPR, comprised of a 25-minute power point slide show and a 25-minute video. All participants completed self-learning via Google Classroom (Alphabet Inc., Mountain View, USA). The participants took compression-only (C-O) practical examination consisting of 180 chest compressions after 5-minute C-O CPR using Resusci Anne SkillReporter (Laerdal Medical, Stavanger, Norway). The collected data were analyzed at an ⍺=.05 using the SPSS 20.0 for Windows (IBM Inc, New York, USA). Changes in willingness, knowledge, performance, and attitude toward CPR before and after the practical exam were analyzed using t-tests. Willingness to perform CPR increased from 1.78 to 2.02, showing a statistically significant change (p=.040). The knowledge score increased from 3.12 to 3.56 and performance score increased from 2.87 to 3.36. The attitude score increased from 3.39 to 3.69, and all these changes were statistically significant (p<.001; p<.001; p<.001). The practical exam on self-learning of basic CPR was effective on improving willingness, knowledge, performance, and attitudes of non-healthcare providers.
Educational Leadership in Improving the Quality of School-Based Education
Authors: Pratiwi Sri Nurabdiah
Published: September 2024

Background. Quality education is inseparable from how leaders can empower all elements in schools by school conditions. Improving the quality of school-based education, starting from the state of schools that are believed to have weaknesses, is time for improvements.
Purpose. Therefore educational leaders must be observant in seeing which conditions are most important for improvement or change so that the goal of improving the quality of school-based education achieves its goals. Making changes in the context of improving the quality of education cannot be done alone but requires the full support of all elements of the school, starting from educators, education staff, students and the school community.
Method. This article uses the literature review method by analyzing several research results and some literature related to educational leadership and school-based quality. The literature review method collects data using various literature, such as books, journals, and other references that are considered appropriate to the research topic Results. Effective educational leadership can cover all aspects of schools' need to improve quality, especially the quality of teaching staff as the frontline. The qualified teaching staff is a benchmark for school progress which will eventually become the quality of education. Therefore, it needs to be empowered according to the expertise possessed so that the quality of teaching staff can be improved sustainably. Educational leadership in carrying out their duties must be distinct from their leadership style, which also affects the quality of education.
Conclusion. In addition, educational leadership also has competencies that are part of the leader's self to realize the achievement of educational goals.
Character Education Model in Islamic Religious Education in Public High Schools in the City of Mataram
Authors: Dwiyani Aryanti , Fadli Adi , Jumarim Jumarim , Fitriani Muh. Iwan , Fuadi Abdullah , Yorman Yorman
Published: September 2024

Background. Character education is a value education that emphasizes moral or ethical aspects. The term character is known as morals which not only emphasizes moral knowledge (moral knowing/learning to know), but also moral formation (moral feeling/moral loving) and application or actualization of values (moral action/moral doing).  
Purpose. The purpose of this study is to describe the types of Islamic religious education activities that become a medium for strengthening character, forms of character that are strengthened through Islamic religious education activities and models of strengthening character values through Islamic religious education for students in public high schools in Mataram City.
Method. This research is a qualitative research with data collection using observation, interviews and documentation. Data analysis uses the Miles and Huberman model starting from data collection, data condensation, data presentation and conclusions. Data validity was carried out with observation persistence, extension of participation, reference and triangulation.
Results. The results showed that the model of strengthening character values through Islamic religious education at school was carried out through three process/stage models, namely: a) Knowledge of morals, b) Moral formation, c) Application or moral actualization which emphasizes the actualization of character values both in the school environment and in the wider environment.
Conclusion. he character education model in this school is carried out with two models, namely the hidden curriculum model and the integration model.
Development of Edpuzzel as an Interactive Media in Muraja'ah Program for Junior High School Students
Authors: Sari Lisa Candra , Kustati Martin , Sepriyanti Nana , Novrianti Novrianti
Published: September 2024

Background. One of the factors that influence the success of the implementation of learning programs is the teacher, the teacher is believed to be one of the dominant factors that determine the level of student success in achieving results in the learning process
Purpose. This study aims to develop Edpuzzle as an interactive media that matches the eligibility criteria of media and materials to improve students' muraja'ah abilities.
Method. This type of research is R&D with a 4D development model whose stages are. Define, Design, Development and Disseminate.
Results. Overall, the interactive learning video media product tawaasilul aayat method in middle class tahfizh subjects at SMPs IT Tahfizh Adzikra Padang is "Very Valid" so it deserves to be tested in tahfizh learning, especially in the field of muraja'ah.
Conclusion. Based on the data processing process carried out, this study showed the results obtained by 3.62 or 72.3% of the first stage of media experts with the category "Valid", 4.15 or 83% of the second media experts of the first stage with the category "Very Valid".
Strategy for Implementing Blockchain Technology in Higher Education Administrative Management
Authors: Mufron Ali , Najoan Meicsy E.I , Utomo Bekti
Published: September 2024

Background. Higher education institutions are faced with demands to increase efficiency and security in administrative management, including management of student data, certification, transcripts, and others. With the many changes in student administration data and the importance of security and transparency in the administration process, blockchain technology has become a concern in providing innovative solutions in this regard.
Purpose. This research aims to analyze the potential and benefits of implementing blockchain technology in higher education administrative management with a focus on security, efficiency and transparency.
Method. Research Method: The research method used includes a literature study regarding information technology and higher education management, as well as a comprehensive analysis of blockchain implementation in managing student administrative data.   
Results. The research results show that the implementation of blockchain technology in higher education administrative management can increase data security and transparency, reduce administrative costs, speed up the certification verification process, and enable the development of a more efficient administrative management system. Conclusion. In conclusion, this research confirms that blockchain technology has great potential to change the management paradigm of higher education administration by providing better data security, increasing process efficiency, and creating a more transparent and decentralized administrative environment. Thus, the implementation of blockchain technology in higher education administrative management can provide significant benefits in facing the complex challenges faced by these educational institutions.
Al-Qur'an Literacy as an Effort of Character Strengthening in Science Learning in Elementary Schools
Authors: Jusuf Ridwan , Srinawati Risna , Abdullah Taufik
Published: September 2024

Background. The learning of natural sciences at Islamic elementary schools in Central Ternate has not yet been integrated with the verses of the Koran. There is still a dichotomy between general knowledge and religious knowledge, even though all of this knowledge originates from the Al-Quran.
Purpose. This study aims to dig deeper into the integration of verses from the Koran in science learning at Islamic Elementary Schools in Central Ternate City. This study uses a phenomenological approach to the triangulation model. Respondents in this study were 15 people consisting of 3 school principals, 3 class teachers, and 9 grade 4 students of SD Islamiyah in Central Ternate City.
Method. Data collection techniques in this study are observation, documentation, and in-depth interviews related to research variables. The research data were analyzed descriptively.  
Results. The results showed that based on the results of observations of learning activities in class 4 SD Islamiyah in Ternate City, it had not been found integrating science learning with verses from the Qur'an, meaning that learning only focused on science subject matter, had nothing to do with verses. Al-Qur'an related to science material being taught, but students' character building can be seen clearly when learning activities take place.
Conclusion. The same thing was also obtained from the results of interviews with school principals, class teachers, and students that the implementation of learning by integrating verses of the Qur'an had not been carried out because the school was still carrying out learning by referring to the established curriculum, so there was no connection between Al -Qur'an and any subject matter conveyed by the class teacher.
Language Teaching and Learning: Effective Strategies for Improving Language Competence
Authors: Zai Syukur Berkat , Ginting Destin Elsa Putri , Bawamenewi Arozatulo , Gulo Ester Ceria
Published: September 2024

Background. The language learning process must be accompanied by language skills strategies, namely listening, speaking, reading and writing skills. All these strategies are very important to improve language skills. With these strategies, the learning process will run well. Good language skills can help people interact and communicate with the people around them.
Purpose. Along with the development of the times and technology, Indonesian is also an inspiration to be introduced and developed throughout the world. The technique used in data collection is to use the discussion lecture method, as well as the team teaching technique.
Method. The purpose of this research is that a better language skills learning process can provide good results and achievements for students.   
Results. The results showed that with effective steps, teachers can use them to teach students' language competence and not only use the lecture learning model.
Conclusion. Based on questionnaires that have been distributed to students, researchers obtained results that show that in learning Indonesian, especially language competence, the strategies used by researchers are effective.
Use of Online Websites as Interactive Learning Media in Moral Creed Lessons
Authors: Wahyuni Erna , Jumiyah Rahmi , Asry Wina
Published: September 2024

Background. The world of the internet is developing very rapidly in this era, in the world of education this technological device is really needed, the use of the internet is closely related to the world of education in the learning process, so that educational institutions have high enthusiasm for developing the use of technology in learning activities.
Purpose. The aim of this research is to explain how to use online websites as an interactive learning medium for learning material on moral beliefs.
Method. The research method used by researchers is a quantitative method, namely survey model, interviews via the Google Meet application and via Google Form.   
Results. The results of this research are to increase students' enthusiasm for learning in the use of learning media and increase students' motivation in learning.
Conclusion. The limitations of this research are that the researcher developed an online website platform as a medium and also a learning resource in a district level school and as a tool to motivate and improve learning achievement. students, therefore future researchers can carry out the same research but developed it for several schools across provinces in Indonesia.
The Role of Islamic Religious Education in 21st Century Science and Technology
Authors: Wantu Hasyim Mahmud , Intes Amina , Barroso Uwe , Siyono Siyono
Published: September 2024

Background. Today's science and technology play an important role in education. However, it resulted in many changes in the social and moral order. Students are required to catch up and master increasingly sophisticated science and technology. So the process of forgetting religious and moral values because they are considered ancient, stylish things are considered advanced and modern. The influence of advances in science and technology can be countered by means of education, especially Islamic Religious Education.
Purpose. The role of Islamic Religious Education helps to restore morals and ethics in the pursuit of science and technology. This role is explained in the Koran that humans are created with eyes to see, ears to hear and hearts to consider what is pursued in gaining knowledge. The aim of this research is to determine the role of Islamic Religious Education on science and technology.
Method. This research involves students to get the desired results. The method used in the research is a quantitative method by distributing questionnaires to students via Google Form
Results. The research results show that the role of Islamic religious education in science and technology has a big influence on the educational process.
Conclusion. The conclusion from the research is that the role of Islamic Religious Education must be increased further in following developments in science and technology. Therefore, the limitation of the research is that the researcher did not undertake to look at the role of Islamic Religious Education in the world of science and technology in the 21st century. The researcher hopes that future researchers will carry out the same research in order to obtain in-depth and comprehensive research results so that the results are maximum.
Self Regulated Learning: Its Role and Influence in Increasing Student Achievement and Interest in Learning
Authors: Intes Amina , Xavier Embrechts , Nitin Mahon
Published: September 2024

Background. Nowadays, many students carry out learning activities without any planning and evaluation of their learning itself. So many students do assignments haphazardly, submit assignments not on time and are late in learning. This is because students are not yet able to regulate themselves in learning which can influence students' low academic achievement.
Purpose. The aim of this research isto improve student achievement and interest in learning through self-regulated learning.
Method. Method used The researcher used a quantitative method in conducting this research by distributing research questionnaires via Google Form.Results of this researchThere have been many important findings that self-regulated learning can help students improve their ability to learn and understand material.  
Results. Limitations of this researchis that researchers only conduct surveys on certain students so it will be difficult to obtain appropriate data in choosing ideal student learning methods.Researchers hopefor future researchers to be able to conduct surveys on all students and not just certain students.
Conclusion. Conclusions from this researchexplained that self-regulated learning plays an important role in increasing student achievement and interest in learning. Because it can make it easier for students to understand the lessons explained by the teacher.
The Importance of Religious Counselors in Building Moderate Attitudes in Moderate Villages
Authors: Ghandi Ghandi
Published: September 2024

Background. Implementing religious moderation in villages is crucial for fostering an understanding of harmonious and non-extreme attitudes within society. This approach helps to maintain social cohesion and prevent conflicts that may arise from radical or extremist views.
Purpose. The main goal of this research is to highlight the importance of religious educators in promoting and implementing the values of religious moderation in village communities. By focusing on moderate Islam, the study aims to integrate these values into everyday life through various religious and community activities.
Method. This research employs a combination of primary and secondary data. Primary data is collected through interviews with key individuals involved in promoting religious moderation, such as religious educators and community leaders. Secondary data includes documentation and observations conducted during field studies.
Results. The study reveals that the values of religious moderation are essential for creating peaceful and balanced community life. Religious instructors play a pivotal role in this process, acting as both leaders and coaches in fostering a moderate Islamic perspective. The research shows that incorporating religious moderation into daily village activities helps to strengthen the community's understanding of these values, reducing the likelihood of extremist behaviors and enhancing social harmony.
Conclusion. The findings underscore the importance of religious educators in embedding the principles of religious moderation within village communities. By leveraging their influence and organizing various religious and community events, these educators effectively promote a moderate approach to Islam, contributing to a harmonious and stable society.
Implementation of Fishbone Analysis in Managing Warehousing Problems at PT Sari Warna Asli V Kudus
Authors: Mirza Muhammad Navis , Prasetyo Iwan , Shopiyan Viki
Published: September 2024

Background. Warehouse management is crucial for manufacturing companies to ensure production runs smoothly and demand is met efficiently. Poor warehouse management can lead to several issues, such as dirty and dusty conditions, inconsistent goods recording, and suboptimal spare parts layouts. These problems can hinder operational efficiency and disrupt production.
Purpuse. This research aims to address inefficiencies in the spare parts warehouse management at PT Sari Warna Asli V Kudus. Specifically, the study seeks to identify the root causes of these issues using fishbone analysis and propose practical solutions to improve the warehouse's operational efficiency.
Method. The study was conducted as part of a student internship from February to April 2024 at PT Sari Warna Asli V Kudus. It involved a preliminary review, problem identification, data collection from primary and secondary sources, and the application of fishbone analysis. The process included gathering data, creating a causal factor diagram, identifying the root causes, and recommending solutions.
Results. The research found that the main problems in the warehouse included the lack of a Standard Operating Procedure (SOP) for managing warehouse activities such as receiving and sending goods, cleanliness, regular inspections, and stock management. These gaps contributed to the inefficiencies in the warehouse operations.
Conclusion. To improve warehouse management at PT Sari Warna Asli V Kudus, the study recommends the implementation of consistent SOPs, regular inspections, and monthly stocktaking. Additionally, warehouse staff should receive training to enhance their skills and knowledge. These measures are expected to significantly improve warehouse conditions and overall operational efficiency.
Effectiveness of Using Audio Visual Media in Improving Student Achievement in Mathematics Learning in Elementary Schools
Authors: Sappaile Baso Intang , Yusuf Nur Fajrin Maulana , Mardiati Mardiati , Zoraida Masli Nur cahya , Sitepu Ediaman
Published: September 2024

Background. Audio-visual media is media that contains elements of sound and images. It is useful for conveying information, knowledge, ideas, ideas in a more interesting way. The proper use of audiovisual media in accordance with the needs in education will be able to improve learning achievement. Audio visual media will help students in developing logical, critical, and creative thinking skills in solving problems. The use of audiovisual media in learning mathematics can improve student achievement in elementary school. This can be achieved as long as the use is effective and efficient.
Purpose. This study aims to measure the effectiveness of using audio-visual media in improving student achievement in mathematics learning in elementary schools. This research will also be useful to find out the factors that influence the success of using audio-visual media. In addition, it is also to find out how far audiovisual media can help students in understanding mathematical concepts, increase learning motivation, and develop logical, critical, and creative thinking skills.
Method. The method used in this research is quantitative. Quantitative method is a way of presenting data in the form of numbers. The data obtained is the result of the acquisition of responses. The data is taken from the distribution of questionnaires containing questions related to the effectiveness of the use of audio-visual media in improving student achievement in mathematics learning at the elementary school level.
Results. The results of this study state that the use of audio visual in math learning in elementary schools can improve student achievement. The use of audiovisual media has a positive effectiveness in learning mathematics in elementary schools. The use of audiovisual media can improve student learning outcomes, concept understanding, ability to analyze, and interest in learning. However, the use of this media must also pay attention to certain factors in order to be effective.
Conclusion This research can be concluded that audio visual media as a learning medium that contains elements of sound and images will be able to be used to convey information, knowledge, ideas, or ideas more interestingly. The use of audio-visual media in learning mathematics will help in improving students' concept understanding, interest, and learning outcomes.
The Relationship Between the Duration of Gadget Use and Students' Ability to Concentrate
Authors: Putri Sarah Ajrina Husni , Bashori Khaeruddin , Samsuddin Muh.
Published: September 2024

Background. The use of gadgets is increasing day by day, from children to adults. The use of gadgets certainly has a positive impact and also a negative impact. Children who are still in school will feel the effects of gadget use. The use of gadgets in proper control will have a good effect on the child's growth and development process. But on the other hand, excessive use of gadgets will affect children's development. In addition, it will also affect the social conditions of children in everyday life.
Purpose This study aims to determine how much the relationship between the duration of gadget use and students' concentration ability. Gadgets at this time are not a foreign thing, wise use of gadgets will provide benefits for users. The use of gadgets in different durations will have a different impact on their use.
Method. The method used in this research is quantitative. Quantitative methods characterized by the use of numbers in the process will help measure the data obtained. Data collection is in the form of distributing questionnaires made in the form of google from. This will make it easier and shorten the time for collection. Google from contains several questions that will be responded to by teachers and students. The statements presented are matters relating to the relationship between gadget use and student concentration.
Results. The results of this study explain the relationship between the duration of gadget use and students' concentration levels. Using gadgets wisely in time management will give the impression of not being too dependent and focus is maintained. However, excessive intensity of gadget use will have an impact on student health. Students will fail to focus on learning, even students will experience mental health problems. It takes the right strategy in using gadgets, such as setting the duration of use, access permissions, and many more.  
Conclusion his study can be concluded that the duration of gadget use in students will affect the level of concentration. The duration of use that is controlled and not excessive will make students concentrate more. However, excessive use of gadgets and no control from parents or teachers will adversely affect student concentration which will deteriorate.
The Impact of Dependence on Gadgets on Student Concentration and Academic Performance
Authors: Sappaile Baso Intang
Published: September 2024

Background:One impact that can disrupt students' concentration in studying is gadget dependence. This dependency can have an impact on students' academic achievement, such as decreasing test scores and poor learning quality and achievement. Therefore, schools must better monitor students' use of gadgets during lessons at school and notify students' parents or guardians to supervise or limit students' use of gadgets at home.
Research purposes:This research was conducted with the aim of understanding the relationship between the impact of dependence on gadgets on students' learning concentration and academic performance, as well as the extent of the impact of dependence on gadgets on students.
Method:The method used in this research is a quantitative method.This method is a way of collecting numerical data that can be tested. Data was collected through distributing questionnaires addressed to students. Furthermore, the data that has been collected from the results of distributing the questionnaire will be accessible in Excel format which can then be processed using SPSS.
Results:From this research, researchers were able to obtain research results on the impact of dependence on gadgets on students' learning concentration and academic performance, which can indeed have a very big influence on students' focus in learning. However, if the use of gadgets can be utilized properly, the resulting negative impact on students' concentration and academic performance will be less.
Conclusion:Based on the results of this research, it can be concluded that the impact of dependence on gadgets, if used frequently, will have an impact on students' learning concentration. By decreasing student concentration in learning, it can result in fatalities such as decreasing the level of student achievement itself. Therefore, supervision is needed, especially by parents, so that students at home do not always play or use gadgets all the time.
BIOIMAGING AND CHEMOGENETICS IN REDOX METABOLISM STUDIES
Authors: Belousov Vsevolod
Published: September 2024

A deep understanding of the roles of redox metabolites and pathways in physiology and pathology requires molecular tools that enable both visualization of these processes and their selective modulation. Over the last two decades, a number of genetically encoded fluorescent biosensors for key redox metabolites have been developed, allowing real-time detection in living systems of varying complexity. Recent developments in this area include the ultrasensitive probe HyPer7 and a new fluorogenic probe, HyPerFAST, which enables even more sensitive H2O2 detection across any chosen optical range, from blue to near-infrared. Complementary to imaging with biosensors, chemogenetics offers tunable substrate-dependent modulation of metabolic pathways, allowing the study of normal cell functioning and modeling dysfunctions caused by abnormal pathway activity and/or metabolite levels. We will present recent developments in this area that include insights on oxidative stress brought about by the use of D-amino acid oxidase (DAO) and intriguing details of the Warburg effect brought about by a new mitochondrial "booster," Grubraw, based on bacterial D-amino acid dehydrogenase.
THE ASSOCIATION OF TUMOR SIZE AND THE PRESENCE OF LYMPH NODE METASTASES IN BREAST CANCER PATIENTS
Authors: Udicki Mirjana , Drvendžija Zorka , Srdić Galić Biljana , Zakić Tamara , Janković Aleksandra , Korać Aleksandra , Korać Bato
Published: September 2024

Breast cancer is one of the most common malignant diseases in women worldwide. Since the involvement of axillary lymph node metastases is related to the poor prognosis of these patients, the objective of our study was to investigate the association between breast tumor size and the presence of axillary lymph node metastases. Our research was performed at the Institute of Oncology of Vojvodina in Sremska Kamenica. The study consisted of 72 women diagnosed with breast cancer aged between 29 and 84 years (average age: 59.04±10.87 years) whose breast tumor was surgically removed at the Institute of Oncology of Vojvodina. Patients who received preoperative chemo- or radiotherapy were excluded from the study. The data concerning breast tumor size and the presence of axillary lymph nodes in these women was obtained from the reports of Department of Pathoanatomical Diagnostics of the Institute of Oncology of Vojvodina. The results of our study indicated to positive, statistically significant moderate correlation between the size of breast tumor and the presence of axillary lymph node metastases (r=0.32, p=0.01). Receiver operating curve (ROC) analysis notified that cut-off value of breast tumor size for the presence of axillary lymph node metastasis was 22.5 mm (AUC=0.70, p=0.01). In our investigation, women with breast tumor size of 22.5 mm or larger were predisposed to the presence of axillary lymph node metastases.

This research was supported by the Science Fund of the Republic of Serbia, #7750238, Exploring new avenues in breast cancer research: Redox and metabolic reprogramming of cancer and associated adipose tissue - REFRAME.
PROGNOSTIC POTENTIAL OF LEUKOCYTE TELOMERE LENGTH AND PARAOXONASE 1 ACTIVITY IN SMALL CELL LUNG CANCER
Authors: Guzonjić Azra , Jovanović Dragana , Simić Ivana , Ćeriman Krstić Vesna , Samardzić Natalija , Ostanek Barbara , Marc Janja , Sopić Miron , Kotur Stevuljević Jelena
Published: September 2024

Small cell lung cancer (SCLC) is the leading cause of cancer-related deaths worldwide and is characterized by rapid growth, early metastasis, and high mortality rates. This study investigated the prognostic potential of leukocyte telomere length (LTL) and paraoxonase 1 (PON1) activity in 60 SCLC patients treated with a cisplatin/etoposide (PE) regimen. Patients were observed at baseline, after 2 cycles, and after 4 cycles of chemotherapy. The primary objective was to evaluate the prognostic potential of these biomarkers for patient survival. LTL was measured from isolated genomic DNA using real-time quantitative polymerase chain reaction (RTq-PCR), while PON1 activity was determined using a spectrophotometric method. A Kaplan-Meier survival analysis was performed with cut-off values below the 25th percentile for LTL and PON1 activity to determine their prognostic power for overall survival. The analysis revealed that both LTL and PON1 are significant predictors of patient survival, suggesting that patients with levels below the 25th percentile have a higher risk of death (Log Rank = 3.956, p = 0.047; Log Rank = 3.834, p = 0.050, respectively). Telomeres, the protective caps at the ends of chromosomes, shorten with each cell division and reflect cell aging and genomic stability. Shorter telomere lengths in leukocytes have been associated with a poorer prognosis and lower survival rates in SCLC patients. Similarly, reduced PON1 activity is associated with increased oxidative stress, which contributes to cancer progression and poorer clinical outcomes. Monitoring PON1 activity could help in assessing patient prognosis and adjusting treatment strategies. These findings suggest that LTL and PON1 activity have significant prognostic value in SCLC and serve as useful indicators for identifying high-risk patients and guiding treatment decisions to improve outcomes.
Academic Performance of Nursing Students with Online Practice
Authors: Qiong Zhang , Dolendo Glenn
Published: September 2024

The study looked at the academic performance and the level of online learning practice of 206 nursing students during three to four months. An instrument with two modules, including general information on students and general information on online internships (Time Management, Course Communication, Course design, Perceived usefulness, Faculty technical competence, Clinical ability, and Research ability), was developed. One-way ANOVA and t-test inferential statistics were used to determine the difference between the elements in online practice and academic performance among nursing students when categorized by gender, grade ranking, organization units of an online internship, and connectivity status. Six students' Key Informant Interview (KII) serves only as supporting information for discussing the highlighted results. The findings showed that nursing students use online learning extensively, and there is no discernible difference in their academic achievement depending on any aspect of online practice other than perceived utility. However, disparities were noted based on connectivity status and organization unit. The study found a strong correlation between academic achievement and online learning practices. The Key Informant interview themes included acceptability, necessity, new knowledge, self-discipline, convenience, and perseverance. Online practice for nursing students is necessary and effective in this particular period. Hospitals and universities should jointly develop an online practice with superior resources and provide students with a good learning environment and resources. Keywords: academic performance, nursing students, online practice
Allometric equations to estimate volume, biomass and carbon of Schizolobium parahyba var. amazonicum (Huber ex Ducke) Barneby in a commercial stand in southwestern Amazonia
Authors: Faustino da Silva Karine Milene , Cerruto Ribeiro Sabina , Benitez Romero Flora Magdaline , Janones da Rocha Karen , Reis Prazeres Mascarenhas Adriano , Biazatti Scheila Cristina , Martin Fearnside Philip
Published: September 2024

Forest plantations with tropical species lack allometric equations to estimate yield. This study aims to test allometric models for estimation of volume, biomass and carbon stock for stems of Schizolobium parahyba var. amazonicum, a species with great potential for using in homogeneous stands. A plantation of S. parahyba was inventoried, rigorously cubed and wood disks with bark were collected to obtain the biomass and carbon stock of the stem. Allometric models were fitted using as independent variables diameter at 1.30 m from the ground, total height, basic wood density and carbon content. The biomass and carbon stock of the stand were 124 Mg ha-1 and 58 Mg C ha-1, respectively. The selected equations for volume estimation with and without bark were V=exp⁡(-9.600+0.937*ln⁡d^2 h) and V=exp⁡(-9.622+0.938*ln⁡d^2 h), respectively; for biomass. the selected equation was B=exp⁡(-9.566+0.936*lnd^2 h+1.014*lnρ). and to estimate carbon stock C=exp⁡(-9.797+0.937*lnd^2 h+1.026*lnρ+0.699*lnt). The allometric equations for volume, biomass and carbon stock fitted in this study can generate more accurate yield estimates for S. parahyba plantations in the Amazon region. Brazil’s commitment under the Paris Agreement to reforest 12 million hectares by 2030 makes improving estimates of volume, biomass and carbon a high priority.
Sustainable Development presupposes Science and Technology
Authors: Braga Bezerra Eronildo
Published: September 2024

Despite the abundance of facts to show that the development of societies has always been intrinsically associated with the use of science and technology as an essential basis for any sustainable development, to date we have seen the defense of ideas metaphysic and antiscientific. This fact, if, on the one hand, evidences the very force of historical materialism to demonstrate that all phenomena are interconnected, interconnected, interdependent and, therefore, in constant movement, transformation and evolution, also highlights the need for permanent development of science and technology as the most appropriate tools depart to face these obscure ideas and provide the necessary subsidies for sustained development, even because development does not occur in a way that occurs rectilinear, which explains the temporal “resurgence” of obscure ideas. It is the expression of the dialectical principle that “the new denies the old man and the old man denies the new”, evidencing that such ideas, for the sake of truth, have always been latent in the different stages of our evolutionary process. Moreover, without the competition of science and technology, we will see a mere predatory economic growth, based on production conceptions, or the eternal process of subsistence advocated by the santuarist currents. The use of science and technology, therefore, is the basis for promoting effective sustainable development, based on the sustainable conception.
Diversity, composition, distribution and similarity of hemiparasites (Loranthaceae and Santalaceae) in the Brazilian Amazon
Authors: Sobrinho Soares Alana Carine , Benitez Romero Flora Magdaline , Da Silva Amaral Samea , Ruduleiro Cruz Ítalo Viturino , Barbosa de Castro Lopes Rosana , Torres Alves Costa José Victor , Marques da Silva e Silva Breno , Lubich Chiara , Leite Rubim Maria Anete
Published: September 2024

The occurrence of hemiparasites in an urban environment is a relevant factor to be monitored, because in imbalance, it compromises the architecture of trees and, because it proliferates easily, can compromise the entire afforestation program. In view of the above, the objective of this research was to perform analyses of hemiparasites (Loranthaceae and Santalaceae) occurring in the urban afforestation of the municipality of Macapá (AP), as well as in the natural ecosystems of the states that make up the Brazilian Amazon. The inventory of tree species was determined in arboreal individuals with ≥ 5 cm diameter at breast height (DBH) and ≥1.30 m in height present in the afforestation of roads and public places in three neighborhoods (Jesus de Nazaré, Centro and Santa Inês) located in the city of Macapá, AP, Brazil. The similarity between environments (hemiparasites and tree species and hemiparasites and infested neighborhoods) was achieved using the Jaccard test. To analyze the similarity between the states that make up the legal Amazon, a survey of the existence of hemiparasites deposited in local herbaria and the occurrence data obtained from the literature review was carried out. Thus, nine bibliographic references were selected. For similarity analysis and multiple correspondence analysis, R software was used, and the Kernel Diagram was used to estimate the density of hemiparasite infestation. The Brazilian Amazon has 107 species of hemiparasites and, of these, the states of AM, PA and MT and the states of MA and TO have the greatest similarities between them. Andira inermis (W. Wright) Kunth ex DC., Ficus benjamina L., Terminalia catappa L. are the main host species of Passovia pedunculata (Jacq.), the main hemiparasite of the urban afforestation of Macapá (AP). The hemiparasites Oryctanthus florulentus (Rich.) Tiegh. and Psittacanthus acinarius (Mart.) Mart. exclusively infest Andira inermis in the urban afforestation of Macapá (AP). The distribution of the aggregated hemiparasites is probably directly related to the phylogenetic and ecological affinity and to the distribution of the hosts in the squares of Macapá (AP)
Virtual Tour dan Pemberdayaan Pesisir sebagai Pengembangan Pariwisata di Desa Kalanganyar, Sidoarjo
Authors: Suksmawati Herlina , Alawi A. Muammar , Nuryananda Praja Firdaus
Published: September 2024

With a very large pond area, Kalanganyar in Sidoarjo is one of the coastal villages that has considerable tourism potential. This tourism potential is emphasized by the existence of tourism assets such as mangroves, rivers that are made to reach ponds, fishing tours, thorn-pulling crafts, and other tourism assets that allow for further development. One of the promotional instruments used by the writing team in promoting Kalanganyar tourism is a virtual tour. Virtual tours have proven to be a promotional instrument that can help the tourism sector during a pandemic. In addition, the activities carried out use a participatory empowerment approach, in which there are social counseling activities and assistance to coastal communities. With the collaboration of these activities, the result was that the creation of a virtual tour for Kalanganyar Village had a side effect, namely increased knowledge of Kalanganyar Makmur BUMDes members and the general public in Kalanganyar about using virtual tours as a means of promotion and completeness of information. In addition, the stakeholders in Kalanganyar Village also provided additional insight that empowering female fishermen could be the next key to empowering coastal communities, especially in Kalanganyar.
Sosialisasi Pendidikan Tinggi Vokasi Sebagai Jembatan Menuju Dunia Kerja di SMK Swasta Harapan Bangsa Tanjung Morawa Kabupaten Deli Serdang
Authors: Ronald Naibaho  , Sinaga Ardian Rahmat Irawan , Napitupulu Abidan , Marbun Rizky Julianto , Sitohang Dody
Published: September 2024

Masyarakat awam belum memahami dengan baik perbedaan pendidikan vokasi dengan pendidikan akademik. Pendidikan tinggi vokasi adalah pendidikan keahlian setara dengan politeknik yang diarahkan untuk mencetak lulusan yang siap bekerja sesuai kebutuhan dunia kerja saat ini. Oleh sebab itulah sekitar 70 persen dari isi program pembelajaran merupakan praktik di industri. Dengan demikian lulusan pendidikan vokasi benar-benar lulusan yang telah memahami dunia industri dan siap untuk bekerja. Pengabdian ini dilaksanakan  kepada 60 siswa kelas 12  Sekolah Menengah Kejuruan (SMK) Harapan Bangsa Tanjung Morawa Kabupaten Deli Serdang yakni mensosialisasikan “Pendidikan Tinggi Vokasi Sebagai Jembatan Memasuki Dunia Kerja“ oleh Tim PkM Program Studi Teknik Mesin Akademi Teknik Deli Serdang. Adapun tujuan Pengabdian kepada Masyarakat ini adalah untuk memotivasi dan melakukan sosialisasi pendidikan tinggi vokasi ke Sekolah Menengah Kejuruan (SMK) swasta Harapan Bangsa Tanjung Morawa Kabupaten Deli Serdang. Sehingga lulusan SMK swasta Harapan Bangsa memiliki informasi yang benar dan termotivasi untuk melanjutkan pendidikan ke jenjang pendidikan yang lebih tinggi demi  peningkatan SDM yang unggul dan menjawab ketimpangan angkatan kerja. Dari sosialisasi dan motivasi diperoleh siswa yang sangat paham terhadap materi sosialisasi sebanyak 43 siswa (72%), siswa yang  berkeinginan/cita-cita kuliah 15 siswa (25%), siswa yang memilih untuk studi lanjut  D3 (Vokasi) 7 siswa (45%) dari jumlah yang memilih ingin kuliah dan siswa  yang memahami peluang studi lanjut 11 siswa (80%) dari yang memilih ingin kuliah.