bluuebunny/crossref_metadata_2025 huggingface dataset:
Aldosterone and progesterone-secreting adrenocortical adenocarcinoma in a cat with a concurrent meningioma
Authors: Leshinsky Jana , Beatty Julia A , Fawcett Anne , Voss Katja , Makara Mariano , Krockenberger Mark B , Barrs Vanessa R
Published: January 2016

Case summary

A 12-year-old, male neutered domestic shorthair cat was referred for investigation of suspected hyperaldosteronism due to persistent hypokalaemia, hindlimb ataxia, weakness of 1 month’s duration and a left adrenal mass that was detected on abdominal ultrasound. Neurological examination findings at referral were suggestive of a concurrent left forebrain lesion. Hyperaldosteronism and concurrent hyperprogesteronism were confirmed on endocrine testing. On computed tomography (CT) of the abdomen and thorax there was no evidence of local vascular invasion by the adrenal mass or of metastatic disease. CT and magnetic resonance imaging featured a large, focal rim-enhancing extra-axial left forebrain lesion consistent with a meningioma. Surgical excision of the forebrain mass was followed by adrenalectomy 2 weeks later. The tumours were classified on histopathology as a psammomatous meningioma and an adrenocortical adenocarcinoma, respectively. Immunohistochemical staining of the meningioma confirmed the presence of progesterone receptors. The cat remains well 2 years later.

Relevance and novel information

In humans, elevated serum progesterone levels have been associated with rapid growth of meningiomas due to the presence of progesterone receptors on the tumour. This is the first report of a cat with a progesterone and aldosterone-secreting adrenocortical adenocarcinoma and a concurrent meningioma. Clinicians should be aware of the potential effect of elevated progesterone on meningiomas in cats.
Successful Closure of an Esophagopleural Fistula With an Amplatzer Occluder Sealed With Liquid Copolymer, With 3-Year Follow-Up and Review of Literature
Authors: Lassaletta Antonio D. , Laham Roger J. , Pinto Duane S. , Pleskow Douglas K. , Sawhney Mandeep S. , Chuttani Ram , Kent Michael S.
Published: January 2016

Esophageal perforations may recur, and/or develop a mature fistulous tract to the pleura, despite prompt surgical management. Treatment of a chronic esophageal fistula is challenging and may require multiple reoperations. We describe the closure of a controlled, chronic, benign esophagopleural fistula using an Amplatzer occluder and sealed with a liquid copolymer after failed open repair. At 3 years postprocedure, the patient has no further recurrence or complication associated with the repair. Amplatzer plugs and occluders, designed for endovascular and cardiac procedures, are increasingly used off-label for the treatment of complex, recurrent, or otherwise difficult to manage bronchopulmonary, pleural, and esophageal fistulae.
Crystal chemistry of Na-rich rectorite from North Little Rock, Arkansas
Authors: Dietel Jan , Steudel Annett , Warr Laurence N. , Emmerich Katja
Published: January 2016

The rectorite, a regular mixed layer mineral consisting of dioctahedral swelling and non-swelling 2:1 layers, from North Little Rock, Arkansas, was studied to define the crystal chemistry and structural parameters (e.g. layer charge of the different layers, presence of cis/trans-vacancies). X-ray diffraction, simultaneous thermal analysis coupled with mass spectrometry, X-ray fluorescence and cation exchange capacity are used to characterize this rectorite. The rectorite has a coefficient of variation (CV) of 0.19 and a cation exchange capacity of 60 cmol(+)/kg, as determined by the ammonium acetate method. The mineral is best described as a regular interstratification of brammallite-like and highcharged beidellite-like layers. Dehydration occurs at ≈118°C with a mass loss of 6.77% and dehydroxylation occurs in two steps at 470°C and 588°C with an overall mass loss of 4.67%. Peak decomposition of the mass spectrometer curve of evolved water shows ≈20% peak area with a maximum higher than 600°C, indicating ≈20% cis-vacant layers.
Preparation and characterization of kaolinite nanostructures: reaction pathways, morphology and structural order
Authors: Zsirka Balázs , Horváth Erzsébet , Makó Éva , Kurdi Róbert , Kristóf János
Published: January 2016

Clay-based nanostructures were prepared from kaolinites of varying structural order by two different methods. In the first method the kaolinite-urea precursor, obtained by dry grinding, was intercalated further with triethanolamine and the tetraalkylammonium salt was synthesized in the interlamellar space. Exfoliation was achieved by the use of sodium polyacrylate (PAS). In the second method, the kaolinite-potassium acetate (kaolinite-KAc) precursor, obtained via two different methods, was intercalated further with ethylene glycol (EG) and then n-hexylamine (HA). Intercalation with EG was also achieved by heating either directly or with microwaves. The morphology that results depends on the method of precursor preparation, the method of heat treatment and the degree of structural order of the original clay. Higher structural order facilitates the formation of a tubular morphology, while mechanical treatment and microwave agitation may result in broken tubes. Molecular mechanical (MM) calculations showed that organo-complexes may be exfoliated to a d value of 10–11 Å.
Kaolin from Acoculco (Puebla, Mexico) as raw material: Mineralogical and thermal characterization
Authors: Garcia-Valles M. , Pi T. , Alfonso P. , Canet C. , Martínez S. , Jiménez-Franco A. , Tarrago M. , Hernández-Cruz B.
Published: January 2016

The present study determined the mineralogy and thermal properties of kaolin from Acoculco (Puebla), at the eastern Trans-Mexican Volcanic Belt and compared it with the nearby deposits of Agua Blanca (Hidalgo) and Huayacocotla (Veracruz). The mineralogy of the kaolins was determined by X-ray diffraction, infrared spectroscopy and scanning electron microscopy. Thermal behaviour was studied by differential thermal analysis, dilatometry and hot-stage microscopy. The Acoculco deposit is composed mainly of kaolinite and SiO2minerals. In the case of Agua Blanca and Huayacocotla, alunite is abundant in places and minor anatase is also present locally. The Acoculco kaolins are Fe-poor and relatively rich in some potentially toxic elements (Zr, Sb, Pb). They undergo a relatively small amount of shrinkage (∼3–4 vol.%), during firing at 20–1300°C and cooling down to 20°C, except when >10 wt.% alunite is present. These kaolins are a suitable raw material for the ceramics industry. Other applications (pharmaceuticals, cosmetics) would require an enrichment process to eliminate impurities such as Fe oxides.
A holistic view of cancer bioenergetics: mitochondrial function and respiration play fundamental roles in the development and progression of diverse tumors
Authors: Alam Md Maksudul , Lal Sneha , FitzGerald Keely E. , Zhang Li
Published: January 2016

Since Otto Warburg made the first observation that tumor cells exhibit altered metabolism and bioenergetics in the 1920s, many scientists have tried to further the understanding of tumor bioenergetics. Particularly, in the past decade, the application of the state‐of the‐art metabolomics and genomics technologies has revealed the remarkable plasticity of tumor metabolism and bioenergetics. Firstly, a wide array of tumor cells have been shown to be able to use not only glucose, but also glutamine for generating cellular energy, reducing power, and metabolic building blocks for biosynthesis. Secondly, many types of cancer cells generate most of their cellular energy via mitochondrial respiration and oxidative phosphorylation. Glutamine is the preferred substrate for oxidative phosphorylation in tumor cells. Thirdly, tumor cells exhibit remarkable versatility in using bioenergetics substrates. Notably, tumor cells can use metabolic substrates donated by stromal cells for cellular energy generation via oxidative phosphorylation. Further, it has been shown that mitochondrial transfer is a critical mechanism for tumor cells with defective mitochondria to restore oxidative phosphorylation. The restoration is necessary for tumor cells to gain tumorigenic and metastatic potential. It is also worth noting that heme is essential for the biogenesis and proper functioning of mitochondrial respiratory chain complexes. Hence, it is not surprising that recent experimental data showed that heme flux and function are elevated in non‐small cell lung cancer (NSCLC) cells and that elevated heme function promotes intensified oxygen consumption, thereby fueling tumor cell proliferation and function. Finally, emerging evidence increasingly suggests that clonal evolution and tumor genetic heterogeneity contribute to bioenergetic versatility of tumor cells, as well as tumor recurrence and drug resistance. Although mutations are found only in several metabolic enzymes in tumors, diverse mutations in signaling pathways and networks can cause changes in the expression and activity of metabolic enzymes, which likely enable tumor cells to gain their bioenergetic versatility. A better understanding of tumor bioenergetics should provide a more holistic approach to investigate cancer biology and therapeutics. This review therefore attempts to comprehensively consider and summarize the experimental data supporting our latest view of cancer bioenergetics.
Enzalutamide Versus Bicalutamide in Castration-Resistant Prostate Cancer: The STRIVE Trial
Authors: Penson David F. , Armstrong Andrew J. , Concepcion Raoul , Agarwal Neeraj , Olsson Carl , Karsh Lawrence , Dunshee Curtis , Wang Fong , Wu Kenneth , Krivoshik Andrew , Phung De , Higano Celestia S.
Published: January 2016

Purpose

Enzalutamide, a potent oral androgen receptor inhibitor, improves survival in men with metastatic castration-resistant prostate cancer (CRPC) before and after chemotherapy. Bicalutamide, a nonsteroidal antiandrogen, is widely used to treat men with nonmetastatic or metastatic CRPC. The efficacy and safety of these drugs were compared in this randomized, double-blind, phase II study of men with CRPC.

Patients and Methods

A total of 396 men with nonmetastatic (n = 139) or metastatic (n = 257) CRPC were randomly assigned to enzalutamide 160 mg per day (n = 198) or bicalutamide 50 mg per day (n = 198). Androgen deprivation therapy was continued in both arms. The primary end point was progression-free survival (PFS).

Results

Enzalutamide reduced the risk of progression or death by 76% compared with bicalutamide (hazard ratio [HR], 0.24; 95% CI, 0.18 to 0.32; P < .001). Median PFS was 19.4 months with enzalutamide versus 5.7 months with bicalutamide. Enzalutamide resulted in significant improvements in all key secondary end points: time to prostate-specific antigen progression (HR, 0.19; 95% CI, 0.14 to 0.26; P < .001); proportion of patients with a ≥ 50% prostate-specific antigen response (81% v 31%; P < .001); and radiographic PFS in metastatic patients (HR, 0.32; 95% CI, 0.21 to 0.50; P < .001). Beneficial effects with enzalutamide were observed in both nonmetastatic and metastatic subgroups. The observed adverse event profile was consistent with that from phase III enzalutamide trials.

Conclusion

Enzalutamide significantly reduced risk of prostate cancer progression or death compared with bicalutamide in patients with nonmetastatic or metastatic CRPC.
Prolonged Oral Administration of a Pan-Retinoic Acid Receptor Antagonist Inhibits Spermatogenesis in Mice With a Rapid Recovery and Changes in the Expression of Influx and Efflux Transporters
Authors: Chung Sanny S. W. , Wang Xiangyuan , Wolgemuth Debra J.
Published: January 2016

We have previously shown that oral administration of a pan-retinoic acid receptor antagonist in mice daily at 2.5 mg/kg for 4 weeks reversibly inhibited spermatogenesis, with no detectable side effects. To elucidate the lowest dose and the longest dosing regimen that inhibits spermatogenesis but results in complete restoration of fertility upon cessation of administration of the drug, we examined the effects of daily doses as low as 1.0 mg/kg with dosing periods of 4, 8, and 16 weeks. We observed 100% sterility in all regimens, with restoration of fertility upon cessation of the drug treatment even for as long as 16 weeks. There was no change in testosterone levels in these males and the progeny examined from 2 of the recovered males were healthy and fertile, with normal testicular weight and testicular histology. Strikingly, a more rapid recovery, as assessed by mating studies, was observed at the lower dose and longer dosing periods. Insight into possible mechanisms underlying this rapid recovery was obtained at 2 levels. First, histological examination revealed that spermatogenesis was not as severely disrupted at the lower dose and with the longer treatment regimens. Second, gene expression analysis revealed that the more rapid recovery may involve the interplay of ATP-binding cassette efflux and solute carrier influx transporters in the testes.
Tpbpa mediated deletion of Tfap2c leads to deregulation of MAPK, P21, AKT and subsequent placental growth arrest
Authors: Sharma Neha , Kubaczka Caroline , Kaiser Stephanie , Nettersheim Daniel , Mughal Sadaf S. , Riesenberg Stefanie , Hölzel Michael , Winterhager Elke , Schorle Hubert
Published: January 2016

Loss of Tfap2c leads to developmental defects in the extra-embryonic compartment with embryonic lethality at E7.5. To investigate requirement of Tfap2c in later placental development, deletion of Tfap2c was induced throughout extra-embryonic ectoderm at E6.5 leading to severe placental abnormalities caused by reduced trophoblast population resulting in embryonic retardation by E8.5. Deletion of Tfap2c in Tpbpa+ progenitors at E8.5 results in growth arrest of junctional zone. TFAP2C regulates its target genes p21/Cdkn1a and Dusp6, involved in repression of MAPK signaling. Loss of TFAP2C reduces activation of ERK1/2 in the placenta. Downregulation of Akt and reduced activation of pAKT in the mutant placenta are accompanied by impaired glycogen synthesis. Loss of Tfap2c led to upregulation of imprinted gene H19 and downregulation of Tex19.1 and Ascl2. The placental insufficiency post E16.5 causes fetal growth restriction with 19% lighter mutant pups. TFAP2C knockdown in human trophoblast choriocarcinoma JAr cells inhibited MAPK and AKT signaling. Thus, we present a model where Tfap2c in trophoblasts controls proliferation by repressing P21 and activating MAPK pathway and further supporting differentiation of glycogen cells via activating Akt pathway.
Chinmo is sufficient to induce male fate in somatic cells of the adult Drosophila ovary
Authors: Ma Qing , de Cuevas Margaret , Matunis Erika L.
Published: January 2016

Sexual identity is continuously maintained in specific differentiated cell types long after sex determination occurs during development. In the adult Drosophila testis, the putative transcription factor Chronologically inappropriate morphogenesis (Chinmo) acts with the canonical male sex determinant DoublesexM (DsxM) to maintain the male identity of somatic cyst stem cells and their progeny. Here we find that ectopic expression of chinmo is sufficient to induce a male identity in adult ovarian somatic cells, but it acts through a DsxM-independent mechanism. In contrast, the feminization of the testis somatic stem cell lineage caused by loss of chinmo is enhanced by loss of the canonical female sex determinant DsxF, indicating that chinmo acts together with the canonical sex determination pathway to maintain the male identity of testis somatic cells. Consistent with this finding, ectopic expression of female sex determinants in the adult testis disrupts tissue morphology. The miRNA let-7 downregulates chinmo in many contexts, and ectopic expression of let-7 in the adult testis is sufficient to recapitulate the chinmo loss of function phenotype, but we find no apparent phenotypes upon removal of let-7 in the adult ovary or testis. Our finding that chinmo is necessary and sufficient to promote a male identity in adult gonadal somatic cells suggests that the sexual identity of somatic cells can be reprogrammed in the adult Drosophila ovary as well as in the testis.
The H3K4me3/2 histone demethylase RBR-2 controls axon guidance by repressing the actin-remodeling gene wsp-1
Authors: Mariani Luca , Lussi Yvonne C. , Vandamme Julien , Riveiro Alba , Salcini Anna Elisabetta
Published: January 2016

The dynamic regulation of histone modifications is important for modulating transcriptional programs during development. Aberrant H3K4 methylation is associated with neurological disorders, but how the levels and the recognition of this modification affect specific neuronal processes is unclear. Here we show that RBR-2, the sole homolog of the KDM5 family of H3K4me3/me2 demethylases in Caenorhabditis elegans, ensures correct axon guidance by controlling the expression of the actin regulator wsp-1. Loss of rbr-2 results in increased levels of H3K4me3 at the transcriptional start site of wsp-1, with concomitant higher wsp-1 expression responsible for defective axon guidance. In agreement, overexpression of WSP-1 mimics rbr-2 loss, while its depletion restores normal axon guidance in rbr-2 mutants. NURF-1, an H3K4me3-binding protein and member of the chromatin-remodeling complex NURF, is required for promoting aberrant wsp-1 transcription in rbr-2 mutants and its ablation restores wild type expression of wsp-1 and axon guidance. Thus, our results establish a precise role for epigenetic regulation in neuronal development by demonstrating a functional link between RBR-2 activity, H3K4me3 levels, the NURF complex and the expression of WSP-1.
An update around the evidence base for the lower extremity ultrasound regional block technique
Authors: Fanelli Andrea , Ghisi Daniela , Melotti Rita Maria
Published: January 2016

Ultrasound guidance currently represents the gold standard for regional anesthesia. In particular for lower extremity blocks, despite the heterogeneity and the lack of large randomized controlled trials, current literature shows a modest improvement in block onset and quality compared with other localization techniques. This review aims to present the most recent findings on the application of ultrasound guidance for each single lower extremity approach.
An AO* Based Exact Algorithm for the Canadian Traveler Problem
Authors: Aksakalli Vural , Sahin O. Furkan , Ari Ibrahim
Published: January 2016

The Canadian traveler problem (CTP) is a simple, yet challenging, stochastic optimization problem wherein an agent is given a graph where some edges are blocked with certain probabilities and the status of these edges can be disambiguated dynamically upon reaching an incident vertex. The goal is to devise a traversal policy that results in the shortest expected walk length between a given starting vertex and a termination vertex. CTP has been shown to be intractable in many broad settings. In this paper, we introduce an optimal algorithm for the problem based on a Markov decision process formulation, which is a new improvement on AO* search that takes advantage of the special problem structure in CTP. We call our algorithm CAO*, which stands for AO* with caching. CAO* uses a caching mechanism to avoid re-expansion of previously visited states and makes use of admissible upper bounds at a node level for dynamic state-space pruning. CAO* is not polynomial time, but it can dramatically shorten the execution time needed to find an exact solution for moderately sized instances. We present computational experiments on a realistic variant of the problem involving an actual maritime minefield data set.
Software Evolution in Web-Service Ecosystems: A Game-Theoretic Model
Authors: Fokaefs Marios , Stroulia Eleni
Published: January 2016

Service orientation is the prevalent paradigm for modular distributed systems, giving rise to service ecosystems defined by software dependencies, which, at the same time, carry business and economic implications. And as software evolves, so do the business relationships among the ecosystem participants, with corresponding economic impact. Therefore, a more comprehensive model of software evolution is necessary in this context, to support the decision-making processes of the ecosystem participants. In this work, we view the ecosystem as a market environment, with providers offering competing services and developing these services to attract more clients by better satisfying their requirements. Based on an economic model for calculating the costs and values associated with service evolution, we develop a game-theoretic model to capture the interactions between providers and clients and support the providers’ decision-making process. We demonstrate the use of our model with a realistic example of a cloud-services ecosystem.
Una nueva propuesta interpretativa de la ciudad norteamericana: el ejemplo de Canadá
Authors: Lois González Rubén Camilo
Published: January 2016

En numerosas ocasiones, la literatura geográfica y urbanística ha coincidido al definir un modelo de ciudad norteamericana, diferente del europeo. Este modelo se ha elaborado a partir de una serie de características propias del espacio urbano y del sistema de ciudades representativo de Estados Unidos. No obstante, en la presente contribución se procura analizar este concepto partiendo de los ejemplos de ciudad y desarrollo urbano correspondientes a Canadá, que se comparan con los más conocidos del vecino país del sur. El sistema urbano canadiense es policéntrico y está condicionado por el proceso histórico de colonización del país, como en el resto del continente americano. Las principales poblaciones han hecho gala de diversidad étnica y cultural, lo que constituye un atributo reivindicado desde muy diversas instancias, a diferencia de los problemas de segregación y discriminación de las urbes estadounidenses. En cualquier caso, la ciudad está fragmentada en unidades residenciales autónomas (las comunidades), no existe un auténtico sentido de pertenencia al conjunto urbano y los espacios comerciales e industriales responden a una estricta zonificación. Aquí se observa una morfología y estructura urbanas comunes a toda Norteamérica, si bien las urbes en Canadá mantienen una serie de signos diferenciales, basados en la tolerancia y el bienestar, que no se perciben con tanta claridad a lo largo de Estados Unidos.
The Precariousness of Homonationalism: The Queer Agency of Terrorism in Post-9/11 Rhetoric
Authors: Chávez Karma R.
Published: January 2016

After the September 11, 2001 attacks on the United States, people from across the political spectrum offered explanations for the terrorists’ motivations and searched for where to place the blame. Figures that featured centrally in the Cold War, such as the “homosexual-communist-subversive,” would reemerge in new forms in the discourse of this burgeoning War on Terror, including the racialized figure of the “queer-immigrant-terrorist.” This article analyzes conservative media discourse that blamed former Congressman Barney Frank and his “gay agenda” for the attacks due to Frank’s influential role in passing the 1990 Immigration Act. It also explores how conservative and mainstream media reports and commentaries constructed the lead hijacker, Mohamed Atta, as “queer,” and how this (racialized and culturally specific) queerness was argued to be his primary motivation for the attacks. Reading these two kinds of discourse in relation to each other shows that “queerness” becomes the agency of terrorism, and this logic maps onto even the most “homonormative,” white gay bodies.
Redox conditions in the Late Cretaceous Chalk Sea: the possible use of cerium anomalies as palaeoredox indicators in the Cenomanian and Turonian Chalk of England
Authors: Jeans Christopher V. , Wray David S. , Williams C. Terry
Published: January 2016

The cerium anomalies preserved in the Chalk have been investigated as possible palaeoredox indicators of the Late Cretaceous Sea and its sediment. This has been based upon over a hundred new rare earth element analyses of selected samples and grain size fractions from the Chalk. Particular attention has been given to the methodology of differentiating between the cerium anomalies preserved in the bioclastic calcite and those in carbonate-fluorapatite preserved in the acetic acid insoluble residues of chalks. Variations in the cerium anomaly of different particle size fractions of uncemented chalks suggest that fractionation of rare earth elements between the Chalk’s seawater and the various organisms that contributed skeletal material to the bioclastic calcite of the Chalk may have occurred. Post-depositional processes of calcite cementation and late diagenetic sulphidisation have had no apparent effect on the cerium anomaly of the acetic acid insoluble residues. The cerium anomalies associated with the acetic acid insoluble residues from (1) an alternating sequence of chalks and marls from Ballard Cliff (Dorset, UK) typical of Milankovitch cyclicity show a marked diagenetic pattern, whereas those from (2) non-volcanic and volcanic marls display a pattern that is best explained by the variations in the availability of phosphorus and the timing of argillisation of volcanic glass during diagenesis. The general conclusion is drawn that the cerium anomalies preserved in the Chalk can provide an insight into the changing palaeoredox conditions in the Late Cretaceous Sea as well as in the pore fluids of its sediments.
Rückwanderung nach Ostdeutschland
Authors: Fuchs Michaela , Weyh Antje
Published: January 2016

Return migration to East Germany. Spatial patterns and relevance for regional labor markets. We analyze labor market-related return migration from West to East Germany between 1999 and 2012. The spatial patterns of relocating the place of living versus the place of work attribute clear benefits from return migration to the East German districts directly at the former intra-German border, the larger cities and the regions surrounding Berlin. Return migration to rural areas is in most cases undertaken by natives of these regions.
Soliton Solutions of a Generalised Nonlinear Schrödinger–Maxwell–Bloch System in the Erbium-Doped Optical Fibre
Authors: Guan Yue-Yang , Tian Bo , Zhen Hui-Lin , Wang Yu-Feng , Chai Jun
Published: January 2016

In this article, the generalised nonlinear Schrödinger–Maxwell–Bloch system is investigated, which describes the propagation of the optical solitons in an optical fibre doped with two-level resonant impurities like erbium with the fourth-order dispersion taken into account. Bilinear forms are derived via the Hirota method, symbolic computation, and the auxiliary function. Bright solitons can be obtained for the complex envelope of the field and the measure of the polarisation for the resonant medium, while the dark ones have been deduced for the extant population inversion. Propagation of the one and two solitons is analysed with the results that the solitons keep their shapes unchanged after the interaction, except for the phase shifts, which means that the interaction is elastic. Velocities of the solitons decrease when the effect of discreteness and higher-order dispersion increases. For the bound-state solitons, which can be formed among the solitons at the same velocity, the period decreases when the effect of discreteness and higher-order dispersion increases.
The E2F-DP1 Transcription Factor Complex Regulates Centriole Duplication inCaenorhabditis elegans
Authors: Miller Jacqueline G , Liu Yan , Williams Christopher W , Smith Harold E , O’Connell Kevin F
Published: January 2016

Centrioles play critical roles in the organization of microtubule-based structures, from the mitotic spindle to cilia and flagella. In order to properly execute their various functions, centrioles are subjected to stringent copy number control. Central to this control mechanism is a precise duplication event that takes place during S phase of the cell cycle and involves the assembly of a single daughter centriole in association with each mother centriole . Recent studies have revealed that posttranslational control of the master regulator Plk4/ZYG-1 kinase and its downstream effector SAS-6 is key to ensuring production of a single daughter centriole. In contrast, relatively little is known about how centriole duplication is regulated at a transcriptional level. Here we show that the transcription factor complex EFL-1-DPL-1 both positively and negatively controls centriole duplication in the Caenorhabditis elegans embryo. Specifically, we find that down regulation of EFL-1-DPL-1 can restore centriole duplication in a zyg-1 hypomorphic mutant and that suppression of the zyg-1 mutant phenotype is accompanied by an increase in SAS-6 protein levels. Further, we find evidence that EFL-1-DPL-1 promotes the transcription of zyg-1 and other centriole duplication genes. Our results provide evidence that in a single tissue type, EFL-1-DPL-1 sets the balance between positive and negative regulators of centriole assembly and thus may be part of a homeostatic mechanism that governs centriole assembly.
Implementation of the Realized Genomic Relationship Matrix to Open-Pollinated White Spruce Family Testing for Disentangling Additive from Nonadditive Genetic Effects
Authors: Gamal El-Dien Omnia , Ratcliffe Blaise , Klápště Jaroslav , Porth Ilga , Chen Charles , El-Kassaby Yousry A
Published: January 2016

The open-pollinated (OP) family testing combines the simplest known progeny evaluation and quantitative genetics analyses as candidates’ offspring are assumed to represent independent half-sib families. The accuracy of genetic parameter estimates is often questioned as the assumption of “half-sibling” in OP families may often be violated. We compared the pedigree- vs. marker-based genetic models by analysing 22-yr height and 30-yr wood density for 214 white spruce [Picea glauca (Moench) Voss] OP families represented by 1694 individuals growing on one site in Quebec, Canada. Assuming half-sibling, the pedigree-based model was limited to estimating the additive genetic variances which, in turn, were grossly overestimated as they were confounded by very minor dominance and major additive-by-additive epistatic genetic variances. In contrast, the implemented genomic pairwise realized relationship models allowed the disentanglement of additive from all nonadditive factors through genetic variance decomposition. The marker-based models produced more realistic narrow-sense heritability estimates and, for the first time, allowed estimating the dominance and epistatic genetic variances from OP testing. In addition, the genomic models showed better prediction accuracies compared to pedigree models and were able to predict individual breeding values for new individuals from untested families, which was not possible using the pedigree-based model. Clearly, the use of marker-based relationship approach is effective in estimating the quantitative genetic parameters of complex traits even under simple and shallow pedigree structure.
The contribution of computerized axiography to the functional evaluation of the temporomandibular joint: a case report
Authors: Botos Alexandra Maria , Mesaros Anca Stefania , Zimbran Adela Ioana
Published: January 2016

The aim of this case report is to give comprehensive information on the clinical use of computerized axiography (CA) in the evaluation of temporomandibular joint (TMJ) mobility in a patient who undergoes orthognatic surgery. A 20-year-old female patient with class III skeletal anomaly and who underwent orthognatic surgery is presented. Pre- and postsurgical CA recordings for the patient are compared in order to evaluate the functional modifications that appear. The CA is a functional investigation of the TMJ and records the border movements of the mandible: protrusion, lateral movements and open/close. The starting point for every movement is the centric relation position. This allows for very high reproducibility of the CA and the data can later become available for comparison of examinations performed at different times. The CA can offer data to programme an articulator or to evaluate the functional evolution of the TMJs after various occlusal interventions (prosthodontic, orthodontic or orthognatic). After comparing the pre- and postsurgical CA recordings, a significant improvement of the TMJ function after the repositioning of the maxilla and mandible through orthognatic surgery was confirmed. In conclusion, our case confirms the results in literature that  CA is a reproducible and reliable investigation method in the evaluation of TMJ function in orthognatic surgery patients, that it facilitates the monitoring of the evolution of the functionality of the TMJ ever time and that it allows for comparative evaluation of the two TMJs.
Mathematic Model for Prediction of Liver Fibrosis Progression Rate in Patients with Chronic Hepatitis C Based on Combination of Genomic Markers
Authors: Samokhodskaia Larisa Mikhaylovna , Starostina Ekaterina Evgen'evna , Yarovaya Elena Borisovna , Krasnova Tat'yana Nikolaevna , Mukhin Nikolay Alekseevich , Tkachuk Vsevolod Arsen'evich , Sadovnichy Viktor Antonovich
Published: January 2016

Aim of study. To evaluate clinical significance of different combinations of gene polymorphisms IL-1b, IL-6, IL-10, TNF, HFE, TGF-b, ATR1, NOS3894, CYBA, AGT, MTHFR, FII, FV, FVII, FXIII, ITGA2, ITGB3, FBG, PAI and their prognostic value for prediction of liver fibrosis progression rate in patients with chronic hepatitis C (CHC).Subjects and methods: 118 patients with CHC were divided into «fast» and «slow» (fibrosis rate progression ≥0,13 and 0,13 fibrosis units/yr; n =64 and n =54) fibrosis groups. Gene polymorphisms were determined. Statistical analysis was performed using Statistica 10.Results. A allele (p =0,012) and genotype AA (p =0,024) of AGT G-6T gene, as well as T allele (p =0,013) and MT+TT genotypes (p =0,005) of AGT 235 M/T gene were significantly more common in «fast fibrosers» than in «slow fibrosers». Patients with genotype TT of CYBA 242 C/T had a higher fibrosis progression rate than patients with CC+CT genotype (p =0,02). Our analysis showed a protective effect of TT genotype of ITGA2 807 C/T on fibrosis progression rate (p =0,03). There was a trend (p 0,15) to higher fibrosis progression rate in patients with mutant alleles and genotypes of TGFb +915 G/C, FXIII 103 G/T, PAI -675 5G/4G genes. Other gene polymorphisms were not associated with enhanced liver fibrosis. To build a mathematical model for prediction of liver fibrosis progression rate we performed coding with scores for genotypes and virus genotype. Total score correlated with the fibrosis progression rate (R =0,39, p =0,000).Conclusion: Determination of genetic profile of the patient and virus genotype allows to predict the course of CHC.
Ligands of RAGE-Proteins: Role in Intercellular Communication and Pathogenesis of Inflammation
Authors: Uspenskaya Yuliya Aleksandrovna , Komleva Yuliya Konstantinovna , Pozhilenkova Elena Anatol'evna , Salmin Vladimir Valer'evic , Lopatina Ol'ga Leonidovna , Fursov Aleksandr Anatol'evich , Lavrent'ev Pavel Vyacheslavovich , Belova Ol'ga Anatol'evna , Salmina Alla Borisovna
Published: January 2016

The review contains data on the diversity of endogenous ligands of RAGE receptors (receptor for advanced glycation end products) that play an important role in the signal transduction in (patho) physiological conditions. RAGE takes part in various physiological processes like cell growth and survival, apoptosis and regeneration. They serve as regulators of inflammatory reactions due to their ability to induce secretion of cytokines and chemokines. In addition, they facilitate elimination of apoptotic cells and mediate innate immune response. We discuss mechanisms of soluble RAGE production as well as the role of membrane and soluble forms of the receptor in cell signaling. Several endogenous ligands of RAGE are well-known: advanced glycation end products (AGE), amyloid-beta (Аβ), nuclear high mobility group box 1 proteins (HMGB1), and calcium-binding proteins S100A4, S100A8/A9, S100A12 и S100B. The review is focused on the mechanisms of the ligands production, their secretion from the cells of various origin, interaction with RAGE, and associated intracellular signal transduction pathways. Special attention is paid to the role of RAGE in pathogenesis of inflammation, particularly, in brain injury and neurodegeneration.
A Taboo Search Optimization of the Control Law of Nonlinear Systems with Bounded Uncertainties
Authors: Gharbi Amira , Benrejeb Mohamed , Borne Pierre
Published: January 2016

The aim of this paper is to propose a method to determine among the eligible controls of a nonlinear system, with bounded perturbations, the one which minimizes the final error. The approach is based on the implementation of aggregation techniques using vector norms in order to determine a comparison system used to calculate an attractor in view of its minimization by implementation of metaheuristics.
The Maximum Flows in Planar Dynamic Networks
Authors: Schiopu Camelia , Ciurea Eleonor
Published: January 2016

An nontrivial extension of the maximal static flow problem is the maximal dynamic flow model, where the transit time to traverse an arc is taken into consideration. If the network parameters as capacities, arc traversal times, and so on, are constant over time, then a dynamic flow problem is said to be stationary. Research on flow in planar static network is motivated by the fact that more efficient algorithms can be developed by exploiting the planar structure of the graph. This article states and solves the maximum flow in directed (1, n) planar dynamic networks in the stationary case.
Reseña del libro: Organización y resistencia popular en la ciudad de México durante la crisis de 1929-1932, Vázquez Ramírez, Esther Martina
Authors: Collado Herrera María del Carmen
Published: January 2016

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Reseña del libro: Els exiliats catalans: un estudio de la emigración republicana española en México, Pla Brugat, Dolores
Authors: Necoechea Gracia Gerardo
Published: January 2016

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Reseña del libro: Mi Multi es mi Multi : historia oral del multifamiliar Miguel Alemán (1949-1999), Garay, Graciela de…. et al.
Authors: Lacarrieu Mónica
Published: January 2016

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Reseña del libro: Obras, Rhodakanaty, Plotino C.
Authors: Lida Clara E.
Published: January 2016

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Entre Sandino y Somoza : la trayectoria política del poeta nicaragüense Salomón de la Selva
Authors: Molina Jiménez Iván
Published: January 2016

Los objetivos de este artículo son analizar el grado en que el poeta nicaragüense Salomón de la Selva se identificó con la lucha de San­dino; examinar el proceso que condujo a di­cho intelectual a colaborar, en el decenio de 1950, con la dictadura de Somoza; y explorar como, unos 20 años después de la muerre del
bardo, su figura y su producción literaria fueron apropiadas por la cultura oficial san­dinista.
Coincidencias: la ortografía y la construcción de las naciones hispanoamericanas
Authors: Rodríguez Miguel
Published: January 2016

Trata de analizar los antecedentes, las semejanzas y las diferencias que los propios contemporáneos vieron en las propuestas de reforma ortográfica de Andrés Bello, en 1823, y luego de Domingo Faustino Sarmiento, en Chile, y Melchor Ocampo, en México. Tales propuestas se basan en la especificidad del habla en castellano en los países hispanoamericanos que acaban de acceder a la independencia política. Este trabajo relaciona esta reflexión sobre la escritura y el lenguaje con la evolución de una conciencia específica y con la construcción de las identidades nacionales. Por otra parte, intenta someramente situar estas consideraciones en el contexto de su época, evocando el interés de las instancias oficiales por la ortografía tanto en España como en Francia.

 
La insularidad antillana a través de la poesía de Nicolás Guillén y Luis Palés Matos
Authors: Castorena Davis Lorella
Published: January 2016

El objetivo central de este trabajo es realizar un análisis de lo que llamo poesía insular, a partir de dos casos ejemplares: Nicolás Guillén en Cuba y Luis Palés Matos en Puerto Rico. Del vasto y complejo universo de etnias, lenguas, religiones y culturas que constituyen el Caribe, recurriré sólo a estos dos poetas para elaborar una interpretación acerca de las representaciones del complejo insular afroantillano desde la profundidad del mestizaje y la negritud.
Reseña del libro: Breve historia de Tamaulipas, Herrera, Octavio
Authors: Muñoz Laura
Published: January 2016

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Reseña del libro: De colonia a nación : impuestos y política en México, 1750-1860, Marichal, Carlos ; Marino, Daniela, comps.
Authors: Jáuregui Luis
Published: January 2016

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Libros europeos y compendios lingüísticos en el Yucatán del siglo XVI
Authors: Ramos Díaz Martín
Published: January 2016

El artículo recupera algunos de los libros que transitaron por Yucatán en la época de los primeros encuentros entre españoles y mayas. La lectura de libros europeos por parte de indígenas, familiarizados con la escritura de los conquistadores, no sorprende; lo que llama la atención es la continuidad con que lo hicieron. Con similar curiosidad, los franciscanos que evangelizaron compilaron inaugurales vocabularios que, en reflejo de la lectura, se convirtieron en instrumentos con que los indígenas rescribieron su historia.

 
El liberalismo en la historiografía mexicanista de los últimos veinte años
Authors: Galante Mirian
Published: January 2016

En el presente ensayo se presenta una reordenación sistemática de las producciones más recientes que han tratado desde la perspectiva histórica el proceso de consolidación del Estado liberal mexicano. El texto recoge y analiza dichas propuestas con el fin de presentar una panorámica crítica sobre los trabajos que tratan acerca de una temática vinculada a uno de los debates historiográficos más relevantes y enriquecedores en el ámbito latinoamericanista en general y mexicanista en concreto, y que a la vez está generando nuevos planteamientos que subvierten los tópicos tradicionalmente consolidados por la historia oficial.

 

 
Reseña del libro: Diccionario de política internacional, Hernández-Vela Salgado, Edmundo
Authors: Muñoz Laura
Published: January 2016

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Reseña del libro: , Irigoin, María Alejandra ; Schmit, Roberto, eds.
Authors: Ibarra Antonio
Published: January 2016

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Las exportaciones de España a Cuba (1891-1913): pervivencias históricas en la demanda cubana de productos españoles
Authors: Blasco Martel Yolanda , Carreras Marín Anna
Published: January 2016

Este artículo analiza la estructura comercial española con Cuba en los años previos e inmediatamente posteriores a la independencia cubana en 1898. Si bien en términos agregados el fin de la colonia supone la desaparición de importantes vínculos comerciales bilaterales, el análisis de algunas categorías de productos pone de relieve el mantenimiento e incluso incremento de la exportación española a Cuba de algunos de estos productos. La hipótesis para explicar este comportamiento anómalo se basa en la presencia de estrategias de diferenciación de producto cuyo éxito se asocia a las preferencias por "lo español" de un segmento de la demanda cubana.

 

 
Chiapas y el arte de gobernar : apuntes sobre una historia reciente, 1973-1993
Authors: Guillén Diana
Published: January 2016

La coyuntura que en 1994 lleva a la aparición de un movimiento armado en Chiapas involucra elementos de carácter estructural propios de la larga duración y otros más que se gestan en la esfera política dentro del corto plazo. El objetivo del artículo es rescatar esta segunda dimensión y analizar los mecanismos que entre 1973 y 1993 se utilizaron para ejercer ciertas funciones de gobierno, a partir del supuesto de que durante ese lapso los límites del aparato estatal para reproducir el orden quedaron en evidencia.

 

 

 
Reseña del libro: Du Luxe au Confort, Goubert, Jean Pierre, dir.
Authors: Núñez Becerra Fernanda
Published: January 2016

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Los rituales de fundación del siglo XVI y el trazo urbano del pueblo de Querétaro
Authors: Somohano Martínez Lourdes
Published: January 2016

En el artículo se realiza una recuperación de los rituales de fundación mesoamericanos realizados en el pueblo de Querétaro, durante la época colonial temprana, plasmados en las leyendas de fundación y los relatos migratorios de los otomíes a principios del siglo XVIII. Los rituales de fundación, según Bernal García, fueron los receptores y transmisores del modelo urbano mesoamericano. Aquí se pretende indagar en qué medida estos rituales influyeron en el modelo urbano del pueblo de indios de Querétaro. 

 

 
La imagen del cambio en una esquina de Tacubaya
Authors: Morales Leal Felipe
Published: January 2016

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Reseña del libro: Sueñan las piedras : alzamiento ocurrido en la Ciudad de México, 14, 15 y 16 de septiembre de 1847, Granados, Luis Fernando
Authors: Herrera Serna Laura
Published: January 2016

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Cronoscopía: la fotografía de la historia espacial de Los Ángeles y México
Authors: Ethington Philip J.
Published: January 2016

En este ensayo empezaré por examinar la postura teórica que plantea que la historia, siendo espacial, es visible en la fotografía y cartografía. La perspectiva política o social es una metáfora sustentada: las múltiples interpretaciones del pasado están ancladas a sitios específicos en los paisajes globales.  El historiador puede exponer los fantasmas que atormentan el presente, utilizando el método que denomino “el cronoscopio”: una visualización que combina signos fotográficos indicativos con la acción interpretativa y narrativa del texto verbal y con los ademanes connotativos de las bellas artes.   La fotografía estereográfica contiene la profundidad de la historia misma: el observador contemporáneo literalmente mira al interior del pasado.  Esa profundidad de la historia es un desafío y una negación de la temporalidad plana de la modernidad. Para explicar estas tesis enfoco el cronoscopio para exponer los fantasmas históricos vinculando dos de las metrópolis más grandes del mundo, Los Ángeles y la ciudad de México, con la historia de la revolución y contrarrevolución, en los años 1900-1930.

 
Reseña del libro: Martí y Blaine en la dialéctica de la Guerra del Pacífico (1879-1883), Ballón Aguirre, José
Authors: Toussaint Mónica
Published: January 2016

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Reseña del libro: Entre portales, palacios y jardines : el Zócalo de la Ciudad de México, 1840-1935, Aguayo, Fernando , Roca, Lourdes
Authors: Ribera Carbó Eulalia
Published: January 2016

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Desarrollo de la óptica oftálmica y uso de anteojos en la ciudad de México durante los siglos XVII XVIII
Authors: Peralta Rodríguez José Roberto
Published: January 2016

El trabajo se propone esclarecer el desarrollo de la producción de lentes oftálmicas y del uso de anteojos en México durante la época colonial, temática no abordada previamente. La producción de vidrio en la Nueva España  se inicio en el siglo XVI y la de lentes en el año de 1652 por al menos un maestro vidriero español al que se denominaba “Maestro de hacer antoxos y otras cosas de vidrio y carey”. La  comercialización de estos productos se llevó a cabo en una  tienda especializada en 1689 y en el mercado principal. Alrededor de 1786, el “Graduador de Vidrios y Anteojos pasó a realizar la fabricación de lentes y anteojos. Se presume que algunos anteojos usados en el virreinato eran de origen novohispano, mientras que otros eran  importados de Europa, a partir de 1760 en  forma legal. El costo económico de ellos era elevado por lo que sólo un  sector de la población tenía la posibilidad de adquirirlos. Su uso predominaba entre personas que pertenecían a niveles gubernamentales y eclesiásticos altos, así como entre catedráticos de la Universidad. Se considera que la modificación de los intereses comerciales propició que la producción local de vidrio decayera y por ende la de  estos aditamentos, junto con otras actividades artesanales que habían alcanzado un alto nivel de desarrollo. 

 

 
El Romanticismo y el triunfo de lo impreso
Authors: Vailant Alain
Published: January 2016

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