bluuebunny/crossref_metadata_2025 huggingface dataset:
Dynamics of Metabolic and Inflammatory Parameters in Overweight Patients Undergoing Knee or hip Arthroplasty
Authors: Tilinca Mariana Cornelia , Pop Tudor Sorin , Szasz Orsolya Zsuzsa , Barbu Stefan , Nyulas Kinga , Nemes Nagy Eniko
Published: February 2020

Osteoarthritis is a common problem in overweight and obese individuals and may lead to severe forms located especially at the knee and hip joints. Arthroplasty in these cases represents the appropriate treatment to solve the pain and to improve joint mobility. This intervention influences the laboratory parameters in different ways. The aim of the study was to compare pre- and postoperative values of metabolic and inflammatory parameters related to joint replacement surgery in patients suffering from advanced stages of knee and hip osteoarthritis, and to assess the relationship between different laboratory findings, taking into consideration the main cardio-metabolic comorbidities. The study was conducted at the Clinic of Orthopaedics and Traumatology of the Clinical County Hospital Mures between 2016-2017 on 57 overweight patients having severe knee or hip osteoarthritis undergoing total knee or hip arthroplasty. Plasma metabolic tests (uricemia, glycemia, triglycerides, cholesterol) and inflammatory markers (fibrinogen, high sensitive C-reactive protein - hsCRP) were followed in the studied overweight patients in the morning just before arthroplasty and 24 h after surgery. Dynamics of the measured laboratory tests and the relationship between them were assessed. Body mass index, waist circumference and cardio-metabolic associated diseases have also been evaluated. Significant decrease of uricemia, cholesterolemia, plasma triglyceride concentration and significant increase of hsCRP could be observed after joint replacement surgery compared to the previous values measured before the intervention. Glycemia was slightly higher after the arthroplasty, but the difference is not quite significant. Negative correlation could be found between preoperative HDL-cholesterol and plasma triglyceride level, while triglyceride concentration showed positive correlation with LDL-cholesterol and uricemia. BMI showed positive correlation with postoperative fibrinogen values. Hypertension was the most frequent cardio-metabolic comorbidity in the studied group. Significant difference occured in the level of a sensitive inflammatory marker and several biochemical laboratory tests suffered notable changes before and after arthroplasty in the studied group. Metabolic status was deeply affected by such an intervention during the first day after surgery. Laboratory components of the metabolic syndrome were present in close relationship in several patients. Further studies need to be performed for the dynamic assessment of more complex metabolic and inflammatory parameters in patients with similar pathology in order to evaluate the postoperative evolution and to provide appropriate support for these patients in the recovery process.
Antibacterial Activities of Spruce Bark (Picea abies L.) Extract and Its Components Against Human Pathogens
Authors: Tanase Corneliu , Cosarca Sanda , Toma Felicia , Mare Anca , Cosarca Adina , Man Adrian , Miklos Amalia , Imre Silvia
Published: February 2020

Spruce is a used material in the wood industry and bark is regarded as a by-product. The aim of this study was to provide information about natural bioactive compounds from spruce (Picea abies L.) bark with potential therapeutic applications such as antibacterial activity against human pathogens. Spruce bark extract was obtained by the conventional aqueous extraction (EAM), and second with ultrasounds (USM). It was determined the total polyphenols by spectrophotometric methods and individual polyphenols by high-performance liquid chromatography (HPLC). For the determination of minimum inhibitory concentration was used microdilution technique. The following strains were tested: Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas aeruginosa. The yield of extracted polyphenols in the case of spruce bark extract was of 33.8mg gallic acid/gfor EAM and 28.73 mg gallic acid/g for USM. The compounds identified in samples, by HPLC, were vanillic acid and taxifolin.It was found that both extracts have antibacterial capacity for all bacteria tested. The antibacterial effect of both extracts was stronger against Gram positive cocci compared with Gram negative bacilli.Antimicrobial spectra and activities of the fractions and pure isolated compounds from the spruce bark, can be suggested the use of spruce bark in pharmaceutical preparations and as well as a food preservative.
Beneficial Effects of Acetaminophen on the Chemical Mediators Involved in the Closure of Patent Ductus Arteriosus
Authors: Cinteza Eliza , Ungureanu Anda , Balgradean Mihaela , Nicolescu Alin
Published: February 2020

Paracetamol (N-acetyl- para-aminophenol) also known as acetaminophen is a chemical compound used in medical practice for analgesic and antipyretic effects. The mechanism of action is related to the cyclooxygenase (COX) activity, which is not full inhibit as for nonsteroidal anti-inflammatory. Paracetamol selectively inhibits COX activities in the brain, indirectly by reducing COX, which must be oxidized in order to function. In addition to analgesic and antipyretic effects, modulating the prostaglandin synthesis by selective inhibition of COX, a vascular modulator effect was described recently on the closure of the patent ductus arteriosus (PDA). This effect has been described in premature newborns, perhaps by decreasing the prostaglandin production. We present the case of a neonate, 39 weeks gestational age, normal birth weight who presented in the 10 th day of life with a cardiac murmur. Echocardiography evidenced a hemodynamically significant PDA, left ventricular enlargement, severe mitral regurgitation, patent foramen ovale and pulmonary hypertension. Although she was a 10-day- old full-term neonate paracetamol administration was attempted. Paracetamol was administered orally in the therapeutic dose of 15 mg/kg/dose, three times a day for three days. The effect was significant by reducing the diameter of the arterial duct (~50% of initial diameter), reducing the size of the left cardiac chambers, reducing the degree of mitral regurgitation from severe to mild, and disappearance of pulmonary hypertension. In conclusion, paracetamol use can change prognosis through the vaso-modulator on the PDA, at the age of 10 days, on a full-term neonate with a normal birth weight. This effect may also be present in full-term newborns and not only in preterm. Even if the PDA was not closed after three days, the hemodynamic impact disappeared and the child could avoid surgical ligation.
Application of the Measurement of Carotid Intima-Media Thickness for Prediction of the Essential Hypertension in Children
Authors: Manea Rosana , Popovici Bianca Elena , Neculoiu Carmen Daniela , Minea Dan , Calin Alina
Published: February 2020

Hypertension is a major risk factor for progression of the atherosclerotic process and for developing of degenerative cardiovascular diseases in adulthood. The aim of this study is to evaluate how the measurement of carotid intima - media thickness for prediction of essential hypertension in children can be used.The study group included 81 children and the control group 61 children, all aged between 5 - 17 years and 11 months old, and admitted in Children Hospital Brasov in the period of 2009 � 2014. The study protocol included: BMI, blood pressure and Doppler echography of the common carotid artery for each group. Mean age of the patients from the study group was 13.67 years, 43.20 % girls and 56.80 % boys, while in the control group, the mean age was 14.07 years, 54.10% girls and 45.90 % boys. 70.37% of the children from the study group presented obesity, while in the control group 40.98% were obese. The IMTC study group ranged from 0.52 - 0.69 mm and the limits of the normotensive subjects were 0.32 -0.54 mm. In both groups the obese patients were found to have increased carotid artery intima-media, which means that IMTC was positively correlated with BMI (p=0.000001).It is necessary to identify diagnostic methods easily applicable for children, allowing involvement of the characteristics of the arterial wall in the degenerative pathological processes. Increased intima-media ratio is positively correlated with high values of blood pressure.
A Review on Fly Ash as a Raw Cementitious Material for Geopolymer Concrete
Authors: Bouaissi Aissa , Li Long Yuan , Moga Ligia Mihaela , Sandu Ioan Gabriel , Abdullah Mohd Mustafa Al Bakri , Sandu Andrei Victor
Published: February 2020

This paper presents a review on fly ash as prime materials used for geopolymer. Due to its advantages of abundant resources, less in cost, great workability and high physical properties which lead to achieve high mechanical properties. Fly ash is considered as one of the largest generated industrial solid wastes or so-called industrial by products, around the world particularly in China, India and USA. The characteristics of fly ash allow it to be a geotechnical material to produce geopolymer cement or concrete as an alternative of Ordinary Portland cement. Many efforts are made in this direction to formulate a suitable mix design of fly ash based-geopolymer by focusing on fly ash as the main prime material. The physical properties, chemical compositions and chemical activation of fly ash are analysed and evaluated in this review paper. Reference has been made to different ASTM, ACI standards and other researches work in geopolymer area.
Heavy Metal-induced Cuticular Alkane Changes of Tall Fescue (Festuca arundinacea) Plantlets
Authors: Necula Radu , Gille Elvira , Dirtu Alin Constantin , Sandu Ion , Gradinaru Vasile Robert , Petcu Ana , Drochioiu Gabi
Published: February 2020

Heavy metal pollution of ecosystems is of great concern, due to the persistence of metals in ecosystem. In this regard, the mountainous pastures of Romanian Carpathians, especially those in the areas of abandoned mines, need particular attention. The aim of this work was to assess the effect of heavy metals and metalloids exposure on cuticular wax composition of tall fescue leaves (Festuca arundinacea). Therefore, we have particularly investigated the variations of long chain hydrocarbon fractions, which are acknowledged to act as a protection for plants especially in toxic environments. The exposure experiments were conducted in triplicates for arsenic and the following metal ions: Ba2+, Cu2+, Fe2+ and Pb2+. The 0.5 mM aqueous solutions of their corresponding salts were used as treatment solutions. Triplicate experiments were also performed for control samples using distilled water as exposure media. The plantlets were kept for growing in controlled environment for 15 days followed by n-hexane hydrocarbon fraction extraction from 0.5 g of sampled leaves. The obtained extracts were semi-quantitatively analyzed (identification followed by peak area measurement) through an optimized method based on gas-chromatography coupled with mass spectrometry. We focused on the measurement of several long chain n-alkanes with the following number of carbon atoms: C21-C31. Significant differences were obtained between results performed for Ba2+, Pb2+ and Fe2+, when compared to AsO43- and Cu2+, which may suggest multiple mechanisms through which the tested plants could develop and adapt when exposed to various chemicals characterized by different degrees of toxicity.
Biochemical Markers in Patients with Readmission for Congestive Heart Failure
Authors: Namat Razan Al , Constantin Mihai , Miftode Ionela Larisa , Manta Andrei , Petris Antoniu , Miftode Radu , Costache Alexandru Dan , Iliescu Dan , Costache Irina Iuliana
Published: February 2020

Repetitive or recurrent hospitalizations are a general major health issue in patients with chronic disease. Congestive heart failure, is associated with a high incidence and presence of early rehospitalization, but variables in order to identify patients at increased risk and also an analysis of potentially remediable factors contributing to readmission have not been previously reported and it remains still a difficult problem. We retrospectively assessed 100 patients aged between 48-85 years old, of which 75% were men, who had been hospitalized with documentation of congestive heart failure in St. Spiridon County Emergency Hospital. They were hospitalized between 2010-2017. Even if recurrent heart failure was the most common cause for readmission or rehospitalization, other cardiac disorders and noncardiac illnesses were also accounted for readmission. Predictive factors of an increased probability of readmission included prior patient�s medical heart failure history, heart failure decompensation precipitated or accelerated by an ischaemic episode, atrial fibrillation or uncontrolled hypertension. Factors contributing to preventable readmissions included noncompliance with medications or diet, inadequate discharge planning or follow-up, failure of both social support system and the seek of a promp medical attention when symptoms reappeared. We also identified an inappropriate colaboration with family doctors especially for the patients from rural areas. Patients were more likely to cite side effects of prescribed medications rather than nonadherence as a precipitating factor for readmission. Thus, we can appreciate that early rehospitalization in patients with congestive heart failure may be avoidable in up to 50% of cases. Identification of high risk patients is possible and also necessary shortly after admission in order to identify nonpharmacological interventions designed to decrease readmission frequency.
Evaluation of the Effects of a Pinus Brutia Bark Extract on Biochemical Parameters and Blood Pressure in an Experimental Arterial Hypertension
Authors: Paduraru(Giurescu Bedreag) Catrinel Florentina , Filip Nina , Trifan Adriana , Miron Sorin Dan , Badescu Codruta , Costache Irina Iuliana , Namat Razan Al , Diaconescu Bogdan , Dumitrescu Nicoleta , Ciocoiu Manuela
Published: February 2020

The new hypertension therapies which are thought to improve the mechanisms impairing the target organs in arterial hypertension (AHT) would have great practical value. The aim of our study was to investigate the effects of Pinus brutia bark extract (EPb) on serum lipid profiles and oxidative stress in N(G)-Nitro-L-arginine-methyl ester (L-NAME)-induced hypertension. The experiment demonstrated that PbE improved lipid profile and reduced pro-oxidative effects of L-NAME, thus suggesting a possible role of the extract in the management of AHT. Systolic and diastolic blood pressure decrease was significant in the group undergoing simultaneous EPb extract and L-NAME therapy, as compared to the group that was administered only L-NAME. Due to its effects, the Pinus brutia bark extract may be used for the prophylaxis and as adjuvant therapy of cardiovascular conditions.
Synthesis, Characterization and Magnetic Studies of Cobalt (II), Manganese (II) and Copper (II) Complexes containing Nitrogen-Oxygen Donor Ligands
Authors: Zahra Asmat , Mahmud Tariq , Shad Hazoor Ahmad , Tahir Muhammad Nawaz , Rehman Hajira , Shahzady Tanzeela Gulab , Ali Zufiqar
Published: February 2020

Transition metal complexes, [M(COOPh)2(TMEDA)�(OH2)], (where M=Co+2 and Mn+2) and [Cu3(COOPh)2(TEA)2(CH3COO)2] have been synthesized by using sodium benzoate, tetramethyl-ethylenediamine and triethanolamine. The bonding nature and structure of complexes (1), (2) and (3) were explored through X-ray crystallography, IR, elemental analysis and magnetic studies. Single crystal X-ray analysis showed that in (1) and (2) complexes, each M (II) is bridged by two benzoate ions, one TMEDA and one water molecule while in (3) complex, Cu1 is coordinated by four oxygen atoms, two from TEA and two from carboxylate group while Cu2 is coordinated by three oxygen atoms and one nitrogen atom. All three complexes displayed triclinic system with space group P-1. Vibrating sample magnetometer measurement justified that these complexes are soft magnetic materials and can retain a certain value of magnetization even when magnetic field is removed.
Biopolymers with Medical Applications Optimized method for obtaining chitosan-based delivery systems
Authors: Confederat Luminita , Motrescu Iuliana , Constantin Sandra , Lupascu Florentina , Profire Lenuta
Published: February 2020

The aim of this study was to optimize the method used for obtaining microparticles based on chitosan � a biocompatible, biodegradable, and nontoxic polymer, and to characterize the developed systems. Chitosan microparticles, as drug delivery systems were obtained by inotropic gelation method using pentasodiumtripolyphosphate (TPP) as cross-linking agent. Chitosan with low molecular weight (CSLMW) in concentration which ranged between 0.5 and 5 %, was used while the concentration of cross-linking agent ranged between 1 and 5%. The characterization of the microparticles in terms of shape, uniformity and adhesion was performed in solution and dried state. The size of the microparticles and the degree of swelling were also determined. The structure and the morphology of the developed polymeric systems were analyzed by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM).The average diameter of the chitosan microparticles was around 522 �m. The most stable microparticles were obtained using CSLMW 1% and TPP 2% or CSLMW 0.75%and TPP 1%. The micropaticles were spherical, uniform and without flattening. Using CSLMW in concentration of 0.5 % poorly cross-linked and crushed microparticles have been obtained at all TPP concentrations. By optimization of the method, stable chitosan-based micropaticles were obtained which will be used to develop controlled release systems for drug delivery.
Nesteroidic Antiinflammators with Variable Chemical Structure that Prevent Anti-inflammatory Effect in the Carpal Tunnel Syndrome - Compressive Neuropaty of the Median Nerve
Authors: Pendefunda Alice Arina Ciocan , Leata Razvan , Nicolae Vasile , Ancuta Codrina , Craciun Adriana Elena , Cerghizan Diana , Iordache Cristina
Published: February 2020

Musculoskeletal pathology reaches important proportions in dental practitioners. Besides the articular manifestations of inflammatory or degenerative rheumatism, in daily practice we often find patients suffering from abarticular pathological processes, during which tendons, synovial dysplasia, schizophrenia, fascia, aponevrozes are affected. The Carpal Tunnel Syndrome represents a compressive neuropathy of the median nerve inside the carpal tunnel of the wrist. Any condition that lowers the dimensions of the carpal tunnel can cause symptoms of carpal tunnel syndrome. The carpal channel (Carpal Tunnel) is divided by a sagittal fibrous divider into two osteofibrosis osteofibrosis: medial and lateral. This blade separates from the posterior aspect of the flexor retina and is inserted into the carpal bones (scaffold, trapezoid and capita). This syndrome has received particular attention in recent years due to the fact that it can occur in people whose work involves repetitive hand activities. Repeated use of the hand, repetition of the same movements and activities of the hand and wrist, over a long period of time, can cause inflammation of the tendons in the wrist, causing swelling, which puts pressure on the nerve. Symptoms of Carpal Tunnel Syndrome begin gradually - without specific trauma. It is a gradual process for most people, carpal tunnel syndrome is aggravated over time without appropriate treatment. The study includes a batch of 75 dentists from Galati County, selected following the application of the inclusion criteria referring to the presence of signs and symptoms characterizing carpal tunnel syndrome in 2015-2017. Sensitivity disorders and paraesthesias accompanying nerve suffering are symptoms that create discomfort and contributes to the deterioration of pretension and force so useful to the professional act of dental medicine. Perceived cramping pain, often of moderate intensity, located at the fist and distal in the distribution area of the median nerve, rarely the pains are intense and radiate upward along upper limb to shoulder.
Dental Follicle Stem Cells as a Biomaterial for Periodontal Regeneration A proof-of-concept study
Authors: Lucaciu Ondine , Campian Radu Septimiu , Soritau Olga , Berce Cristian , Mester Alexandru , Apostu Dragos , Tabaran Flaviu , Manole Marius , Bordea Roxana , Ionel Dan Cristian , Ionel Anca
Published: February 2020

The goal of periodontal therapy is to regenerate the periodontal structures: cement, periodontal ligament and alveolar bone. Stem cell-based tissue engineering raised novel therapeutic strategies for periodontal repair. In vivo dental follicle stem (DFSC) cells give rise to cementoblasts, osteoblasts and fibroblasts. Based on this idea, we have assessed DFSC potential to regenerate the periodontal structures, and by that to elaborate a new biomaterial. An experimental study was performed on male Wistar rats which were subjected to a procedure of periodontitis induction through placing silk thread ligatures around the lower incisors, under general anesthesia. Clinically, the changes of the periodontal tissue (bleeding on probing, dental mobility, dental plaque, presence of pus) induced by the periodontitis progression were daily assessed. The subjects were divided in two groups: a control and a study group. After 7 days from placing silk thread ligatures, subjects from the study group received an injection in the gingival sulcus. The injected biomaterial contained dental follicle stem cells seeded on fibrinogen. Bleeding on probing at the end of the treatment period was significantly reduced in the study group (study vs control group - 0% vs 100%, p=0.01.). In terms of dental mobility statistical significant results were obtained (p=0.04): for 20% from the subjects from the study group dental mobility was absent, while in the control group all subjects presented different degrees of mobility (33.3% degree II- v-o/m-d, 66.6% degree III-v-o/m-d/ax). In the control group pus was present in 66.7% from the subjects, and absent in the study group (p=0.10). Dental plaque was present in 40% of the subjects from the study group and in 100% in the control group. The clinical and histological results of our study demonstrate that dental follicle stem cells are a valuable cell source for tissue engineering the periodontal tissue.
NMR Studies of the Inclusion Complexes Between Ezetimibe and Cyclodextrins
Authors: Kelemen Hajnal , Csillag Angella , Noszal Bela , Orgovan Gabor
Published: February 2020

Ezetimibe, the antihyperlipidemic drug of poor bioavailability was complexed with native and derivatized cyclodextrins.The complexes were characterized in terms stability, stoichiometry and structure using various 1D and 2D solution NMR spectroscopic techniques. The complexes were found to be of moderate stability (logK[3). The least stable inclusion complex is formed with b-cyclodextrin, while the ezetimibe-methylated-b--cyclodextrin has a 7-fold higher stability. The results can be useful to improve the poor water-solubility and the concomitant bioavailability of ezetimibe.
Novel N-(2-bromo-phenyl)-2-hydroxy-benzamide Derivatives with Antifugal Activity
Authors: Ienascu Ioana Maria Carmen , Balaes Tiberius , Petre Cristiana Virginia , Pop Raluca Oana , Cata Adina , Stefanut Mariana Nela , Albu Paul , Poenaru Marioara
Published: February 2020

In order to increase the biological activity, some novel molecules, esters, hydrazides, hydrazones of N-(2-bromo-phenyl)-2-hydroxy-benzamide, were obtained in good yields (86-93%), working at 150 �C, 500 W, 7-11 min, under microwave irradiation. All synthesized compounds were characterized using modern physico-chemical methods (FTIR, 1H-NMR, 13C-NMR and elemental analysis). Eight dilutions in dimethyl sulfoxide of these derivatives were tested against two phyto-pathogenic fungi, Fusarium oxysporum, Sclerotinia sclerotiorum and one common yeast, Saccharomyces cerevisiae. The antifungal activity was assessed using disc diffusion method, both negative, pure DMSO, and positive control, nystatin, were used. S. cerevisiae was slightly more sensitive than filamentous fungi, the strongest inhibition, MIC=0.3125g/L, was observed for N-(2-bromo-phenyl)-2-hydroxy-benzamide and N-(2-bromo-phenyl)-2-(4-dimethylamino-benzylidene-hydrazinocarbonylmethoxy)-benzamide. The most active compounds against F. oxysporum and S. sclerotiorum were N-(2-bromo-phenyl)-2-hydroxy-benzamide (MIC= 0.625g/L), N-(2-bromo-phenyl)-2-hydrazinocarbonylmethoxy-benzamide (MIC=1.25g/L) and N-(2-bromo-phenyl)-2-(4-dimethylamino-benzylidene-hydrazinocarbonyl-methoxy)-benzamide (MIC=0.625g/L), N-(2-bromo-phenyl)-2-hydrazinocarbonyl-methoxy-benzamide (MIC=1.25g/L), respectively.
Complex Nasal Reconstruction Using Locoregional Flaps
Authors: Marinescu Bogdan Mihai , Stefanescu Cristian Dragos , Tuhar Ioana , Muraru Dragos , Guzganu Ionut , Hainarosie Razvan , Jecan Radu Cristian
Published: February 2020

There is no perfect method of nasal reconstruction. All reconstruction types have advantages and disadvantages equally. Perhaps, the personalized medicine can be best illustrated by this surgical pathology. The present paper describes our experience with locoregional fasciocutaneous flaps together with cartilage grafts as surgical treatment for patients with nasofacial cutaneous tumors. After describing the general conditions for the 12 patients included in the study we presented the surgical management of an old woman with a nasal tumor (basal cell carcinoma) of 50/40/35 mm. Favorable results (from aesthetic and functional point of view) were obtained for most patients included in the study. There was only one recurrence, at 1 year postoperatively to the patient diagnosed with malignant melanoma. Considering the etiopathogenetic mechanisms of nasofacial cutaneous tumors and the other nasal reconstruction procedures, more extensive and multicenter studies are needed.
Effect of Convective Dryness Combined with Osmotic Dehydration, Blanching, Microwave and Ultrasonic Treatment on Bioactive Compounds and Rehydration Capacity of Dried Plums
Authors: Popescu Elena Corina , Avram Daniela , Georgescu Antonia Andreea , Ionita Ionica
Published: February 2020

Increasing interest in keeping bioactive compounds (anthocyanins, vitamin C) and dried fruit quality has motivated the researchers to investigate new combined drying technologies. The objective of this study was to evaluate the effects of convective drying combined with osmotic dehydration, bleaching, microwave treatment and ultrasonic treatment of bioactive compounds (anthocyanins, vitamin C), rehydration capacity and prune drying rate. Osmotic dehydration was achieved by maintaining plums for 1 hour in sucrose solution (300Brix). For microwave treatment, the plums were kept at 400 W for 80 s. For ultrasonic treatment, plums were immersed in distilled water and sonicated for 30 min at 40 kHz and 200 W. The blanching consists of immersing plums in hot water at 900C for 20 s and cooling them rapidly. Convective drying was carried out at 700C. Blanching led to the largest amount of evaporated water. The lowest reduction in anthocyanins, of 34.5%, was obtained for osmotic dehydrated plums. The prunes blanched before drying have had the highest rehydration capacity.
On Some Thermodynamic Processes Possibly Involved in the Technological Flow of Liquefied Natural Gas
Authors: Cristescu Tudora , Suditu Silvian , Stoica Monica Emanuela
Published: February 2020

A global increase in the usage of LNG is expected in the subsequent years. More and more countries are starting to produce LNG, while others are starting to import it, using this energetic solution as a complementary source. The present paper consists of data and calculation relationships regarding certain thermodynamic properties of liquid methane. Also, it discusses a few case studies concerning some thermodynamic processes possibly involved in the technological flow of liquefied natural gas. A calculation model is provided regarding the thermal flow necessary for methane heating, vapourisation and overheating at an LNG unloading terminal. A calculation relationship is also provided for the evaluation of the specific latent heat of liquid methane vapourisation depending on temperature.
Comparative Study Concerning the Methods of Calculation of the Critical Axial Buckling Load for Stiffened Cylindrical Shells
Authors: Zaharia Maria , Pupazescu Alexandru , Petre Cristian Mihai
Published: February 2020

As demonstrated in numerous theoretical and experimental studies [1], the buckling behaviour of stiffened cylindrical shells (SCS) is strongly influenced by the presence of geometric imperfections caused by the manufacturing process and/or exploitation. Therefore, the design norms recommend the use of reduction coefficients with very low values, resulting in a significant reduction of the maximum load applied. In order to calculate the critical buckling load as accurately as possible it is necessary to know the real geometry of SCS. In case of SCS, the structural analysis based on the use of the finite element method (FEM), using models that reflect the real geometry of the shell determined from measurements, lead to a better evaluation of the critical buckling load. The structural analysis with FEM is accepted more and more by standards, EN 1993-1-6:2007 [2] specifying the types of numerical analysis accepted for cylindrical shells. The aim of this study is to compare the results concerning the critical buckling load for SCS under axial compression, obtained with both the analytical and FEM methods for real geometries obtained from measurements. For this purpose, scale models of SCS were used, for which were determined, by measuring, the values of the deviations from the median radius at several points on the shells surface. These deviations were then incorporated in the numerical analysis with FEM and it was determined, for each cylindrical shell, the value of the critical axial buckling load, by using geometrically nonlinear analysis. In order to validate the results of the numerical analysis, the analysed SCS were subjected to axial compression within an experimental program and the experimental data were compared with the results established on the basis of analytical and numerical calculation.
The Influence of Rosehip Polyphenols on the Quality of Smoked Pork Sausages, Compared to Classic Additives
Authors: Nicorescu Valentin , Papuc Camelia , Predescu Corina , Gajaila Iuliana , Petcu Carmen , Stefan Georgeta
Published: February 2020

In this study, pork sausages added with rosehip polyphenols, sodium nitrite, butylated hydroxyanisole (BHA) and tetrasodium pyrophosphate (TSPP) in different concentrations and combinations were prepared, smoked and refrigerated for 20 days. To evaluate the quality of sausages, chemical (peroxide value, thiobarbituric acid reactive substances, and protein patterns), microbiological (total plate count), and sensory (colour, odour, flavour, texture, and taste) analysis were performed. The results showed that the treatment with rosehip polyphenols (0.005%) and sodium nitrite (0.01%) protected sausages against lipid peroxidation as effective as the sodium nitrite (0.01%), BHA (0.005%) and TSPP (0.3%) mixture. Protein pattern of sausages treated only with rosehip polyphenols (0.04%) was similar to that of the sausages treated with sodium nitrite, BHA and TSPP mixture. Microbiological analysis showed that rosehip polyphenols and sodium nitrite combination exhibited a superior antimicrobial activity compared to the one of sodium nitrite, TSPP and BHA mixture. The scores for all sensory attributes continuously decreased with storage time, regardless of the sample type. For all types of sausages, between the refrigeration time, chemical, microbiological, and sensory parameters, statistically significant correlations were found. These findings suggest that rosehip polyphenols could be used as natural additives with multiple preservative functions for smoked sausages.
Pack-Aliting in Thermitic Powder Mixture Obtained by Mechanical Alloying
Authors: Branzei Mihai , Druga Leontin Nicolae , Tudose Florica , Trusca Roxana , Cojocaru Mihai Ovidiu
Published: February 2020

The paper deals with the effects of the structural state modification of the main pulverulent component used for the alloying of metallic products made of steels, cast iron or nonferrous alloys, on the layers kinetics formation. The aliting process is most often done in a powdery mixtures, composed of three components: the active component providing aluminum, a neutral one with the role of dispersing the others, also having the role of blocking the sintering tendency and a halide as an activator, by cleaning the metal surfaces to be saturated. The aim of the paper is to present the ways to ensure the kinetics of the aliting layer formation, while reducing the heat treatment temperature. These could be accomplished by replacing the aluminum or ferroaluminum powder with equimassic amounts mixture of thermitic powders, consisting of ferrous oxides and aluminum powders, mechanically alloyed in high energy ball mills. Thus, it is possible to produce the aluminothermic reduction reaction in the component obtained by mechanical alloying at the same time generating notable thermal effects.
Research Concerning Reducing the Polluation Degrees in the Sectors of Production of Metal Materials
Authors: Dontu Octavian , Constantin Nicolae , Butnariu Ilie
Published: February 2020

This paper contains the results of researches and experimentations on the reduction of the concentration of gaseous emissions and powders in the manufacture of ferrous alloys in aggregates of electric arc furnaces (EBT) coupled with a treatment plant (LF) located at Mechel Targoviste using new technology. Experiments have shown that using the new technology one achieves a reduction in pollutant gaseous emissions by about 30% and in dust content by about 25% compared to the use of classical technology, with particularly beneficial effects on the environment. The results have confirmed the validity of the new technology that used iron sponge in the loading phase, foamed slag in the melting phase and long electric arc in the production phase. The paper presents the results of the experiments using both technologies, as well as the equipment established and used in the experiments for the measurement and recording of the gaseous emissions and powders content, which ensured an accurate evaluation of the obtained results.
Oxidative Stress Status in Patients with Choledocholithiasis: Before and After Endoscopic Sphincterotomy and Biliary Clearance
Authors: Sfarti Catalin Victor , Ciobica Alin , Stanciu Carol , Balan Gheorghe G. , Garleanu Irina , Trifan Anca
Published: February 2020

Choledocholithiasis may cause biliary obstruction which leads to hepatocellular injury. Oxidative stress has been proposed as a possible mechanism involved in this disorder. This study evaluates the oxidative stress burden in patients with choledocholithiasis and secondary cholestasis, before and after endoscopic sphincterotomy. Experimental part: Patients diagnosed with choledocholithiasis and secondary extrahepatic cholestasis were included in the study between January 1st 2016 and October 31st 2016. In all patients oxidative stress markers were collected within 2 hours before and 48 hours after therapeutic ERCP. Selected markers were superoxide dismutase (SOD), glutathione peroxidase (GPX) and malondialdehyde (MDA). The results were compared to those from a group of 40 healthy subjects. Significantly lower concentrations of SOD (p = 0.03) and GPX (p [ 0.0001) activities, associated with an increased level of MDA level (p [ 0.0001) were shown in patients before biliary clearance compared with the healthy control group. After ERCP the only oxidative stress parameter which showed improvement was the SOD specific activity (p = 0.037). This study shows that extrahepatic cholestasis secondary to choledocholithiasis is associated with increased oxidative stress status. After biliary clearance one oxidative stress marker was significantly improved (SOD), suggesting a possible antioxidant effect of such procedure.
Revision Total Knee Arthroplasty Causes of failure, bone loss management and outcomes\
Authors: Viscopoleanu George , Sendrea Bogdan , Haritinian Emil
Published: February 2020

The objectives of the current study were to identify the causes leading to revision knee arthroplasty, analyse implant choices and assess the short-term outcome. The current study is a retrospective on including a group of 33 patients operated between Jan 2013-Dec 2016 in a single institution. Data was collected from the Romanian National Arthroplasty Register. The cause for revision surgery was noted, as well as the type of implant used during the surgical procedure. The bony defect was classified according to the Anderson Orthopaedic Research Institute (AORI) Classification and the reconstruction method was analysed. Functional outcome was assessed using Oxford Knee Score preoperatively and at one year follow-up. Infection was the cause of failure in 18 cases, aseptic loosening in 11 cases, malposition of implants in 2 cases, instability in 1 case and periprosthetic fracture in 1 case. Revision implants were chosen based on joint stability and degree bone loss. The preferred implant was a condylar constrained knee type (20 cases), followed by a rotating hinge type (5 cases). An unconstrained implant was used in 2 cases. Six infected cases required an arthrodesis of the knee. Based on the AORI Classification, there were 10 type III defects, 14 type IIB, 8 type IIA and only one type I defect. Metal augments were preferred for reconstruction of bone defects. Bone graft was used in 8 cases. The mean Oxford Knee Score was 15 pre-op (12-20) and 38 post-op (32-45). Implant survival at final follow-up was 100%. The most common cause of failure of primary total knee arthroplasty is prosthetic joint infection. Bone defects can be addressed using metal augments or bone allograft. Postoperative functional outcome is improved irrespective of the type of implant used.
Is the Acidic pH of the External Auditory Canal Playing a Significant Role in the Treatment of Acute Otitis Externa?
Authors: Iana Oana Ruxandra , Stefanescu Dragos Cristian , Zainea Viorel , Hainarosie Razvan
Published: February 2020

Variable pH values for skin have been reported in the literature, all within the acidic range, varying from 4.0 up to 7. 0. The origin of the acidic pH remains conjectural, and several factors have been incriminated with this role, such as eccrine and sebaceous secretions as well as proton pumps. Keeping low levels of pH prevents microbial dispersal as well as multiplication. The skin in the external auditory canal is also covered with this acidic mantle with antimicrobial value. Changes of pH in the external ear can lead to acute otitis externa. This condition is defined by the inflammation and infection of the cutaneous and subcutaneous tissues of the external auditory canal. 10% of the world�s population may suffer from acute otitis externa at least once in their lifetime. This paper aims to consolidate the relevance of an acidic pH in the healthy external ear and its relation to the pathogenesis and treatment of otitis externa through a prospective and interventional clinical study on 80 patients who presented to the outpatient department at Prof. Dr D. Hociota ENT Institute in Buch
Quantum Mechanical and Spectral Comparative Study of 1-p-Nitro-Benzoyl-Benzo[f]Quinolinium Methylid and 1-p-Nitrobenzoyl-2,3-Dicarbomethoxy-Pyrrolo-[1,2a]-Benzo[f]Quinoline
Authors: Todirascu Antonina Gritco , Morosanu Cezarina , Partenie Doina , Dorohoi Dana Ortansa , Creanga Dorina
Published: February 2020

The quantum mechanical and spectral study of two related compounds, namely, 1-p-nitro-benzoyl-benzo[f]quinolinium methylid (BF1) and its cycloadduction derivative 1-p-nitro-benzoyl-2,3-dicarbomethoxy-pyrrolo-[1,2a]-benzo[f]quinoline (BF2) was carried out. Some electro-optical parameters in ground state were estimated by ab initio method. The solvatochromic behavior of the visible spectrum absorption band of the studied molecules in solvents with different macroscopic electro-optical proprieties was analyzed in order to estimate some microscopic molecular parameters of BF1 and BF2 in the excited state. Thus it was evidenced that, by excitation, the increase of BF1dipole moment and electric polarizability occurred while for BF2 either the increase or the decrease of these two parameters was found. The study is of practical importance for further synthesis of new derived compounds with potential applications in life sciences.
The Relationship Between eNOS (G894T ) Gene Polymorphism and Arterial Stiffness in Patients with Metabolic Syndrome
Authors: Cozma Angela , Sitar Taut Adela , Orasan Olga , Procopciuc Lucia Maria , Farcas Anca Daniela , Stan Adina , Negrean Vasile , Sampelean Dorel , Pop Dana , Zdrenghea Dumitru , Fodor Adriana
Published: February 2020

Metabolic syndrome (MS) is a clustering entity characterized by obesity, hypertension, hyperglycemia, dyslipidemia, and insulin resistance. Atherosclerotic lesions may be a complication of MS, arising from endothelial dysfunction and induced by decreased nitric oxide (NO) production. NO is synthesized by nitric oxide synthase (eNOS), encoded by the NOS3 gene, and displays anti-inflammatory, vasodilatory, and antiproliferative effects.We aimed to investigate the relationship between the G894T polymorphism of the eNOS gene and metabolic syndrome (including its components) and the association of this polymorphism with arterial function, assessed by determining pulse wave velocity and the augmentation index.The study included 100 consecutive patients, 55% with metabolic syndrome (based on IDF criteria -study group), 45% without MS (control group). Arterial stiffness was measured using TensioMedTMArteriograph. The presence of the homozygous (TT) or heterozygous (GT) state was associated, compared to subjects without the mutation (GG), with an increased prevalence of arterial hypertension, diabetes mellitus, with an increase of abdominal circumference, an increase of triglycerides, without significantly influencing the level of HDL. No significant differences were found between patients with G894T polymorphism compared to those without the mutation regarding the arterial stiffness. The eNOS gene polymorphism: 894G]T was significantly associated with the presence of MS; the polymorphism in homozygous and heterozygous state was associated with an increased risk of metabolic syndrome. G894T polymorphism did not significantly influence the values of the studied arterial parameters (pulse wave velocity, aortic and brachial augmentation index).
Process Design in the Manufacturing of Pipes for Chemical and Petrochemical Industry
Authors: Rusanescu Carmen Otilia , Rusanescu Marin
Published: February 2020

In the present study the influence of vanadium microalloy on kinetics of transformation in medium carbon steel is studied. In order to choose the thermal treatment temperatures at optimal values, the steel transformation points were determined by dilatometric analysis. The bainitic transformation point was obtained under fast cooling conditions. The industrial experiments on the hardening and tempered of steel were performed in five variants of the oil hardening and reversing treatment, with austenitizing temperatures for hardening and the tempered temperature. The steel quality was determined, the influence of the temperature on the microalloyed steel structure with vanadium was highlighted. The mechanical characteristics of the pipes after the thermal hardening and tempering were analyzed after the traction test and the shock break. Electron microscopy analysis on extraction replicas revealed aspects of precipitation, globular constituent after return is finely and uniformly distributed, austenitization at lower temperature, resulted in a finer austenitic grain [20]. The finer structure obtained after hardening resulted in heat treatment to return to precipitation of fine and uniformly distributed carbides. It has been found that the influence on bainitic transformation depends on temperature; the steel structure after the quenching and tempering treatment was analyzed by optical and electronic microscopy. The development of welding consumables is permanently challenged with matching the increasing strength and toughness of thermomechanically treated or hardening and tempered steels.
Maternal-Fetal Management in Trombophilia Related and Placenta-Mediated Pregnancy Complications
Authors: Berceanu Costin , Ciurea Elena Loredana , Cirstoiu Monica Mihaela , Berceanu Sabina , Ofiteru Anca Maria , Mehedintu Claudia , Berbece Sorin Ioan , Ciortea Razvan , Stepan Alex Emilian , Balseanu Tudor Adrian
Published: February 2020

It is widely accepted that thrombophilia in pregnancy greatly increases the risk of venous thromboembolism. Pregnancy complications arise, at least partly, from placental insufficiency. Any change in the functioning of the gestational transient biological system, such as inherited or acquired thrombophilia, might lead to placental insufficiency. In this research we included 64 pregnant women with trombophilia and 70 cases non-trombophilic pregnant women, with or without PMPC, over a two-year period. The purpose of this multicenter case-control study is to analyze the maternal-fetal management options in obstetric thrombophilia, the impact of this pathology on the placental structure and possible correlations with placenta-mediated pregnancy complications. Maternal-fetal management in obstetric thrombophilia means preconceptional or early diagnosis, prevention of pregnancy morbidity, specific therapy as quickly as possible and fetal systematic surveilance to identify the possible occurrence of placenta-mediated pregnancy complications.
Assessment of Physical and Chemical Parameters of Four Endodontic Sealants
Authors: Giuroiu Cristian Levente , Andrian Sorin , Pasca Aurelian Sorin , Fatu Ana Maria , Vascu Mihai Bogdan
Published: February 2020

The endodontic sealants have an essential role in the root canal filling. The aim of this study was to analyse and compare three physio-chemical properties (pH, solubility, viscosity). The most significant decrease of the viscosity was for MTA-Fillapex, followed by Endoflas FS and Acroseal. The best behavior was recorded for Endomethasone N. The total decrease of dry mass (reported to baseline) was 0.0113 for Acroseal. Endoflas FS had a total decrease of dry mass of 0.0377 (from 0,6864 to 0.6487) during the study. The total decrease of dry mass (reported to baseline) was 0.0047 for Endomethasone N. MTA Fillapex had a total decrease of 0.0226 (from 0.4805 to 0.4579) during the study period. MTA Fillapex had the highest pH values (pH 10.16), followed by Acroseal (pH 8.79), Endoflas FS (pH 7.98) and Endomethasone N (pH 7.73).