bluuebunny/crossref_metadata_2025 huggingface dataset:
Topical Vancomycin as a Tool for the Prevention of Surgical Site Infections in Cranial Neurosurgery: A Retrospective Cohort Study
Authors: Leal-Isaza Juan Pablo , Garcia Rairan Luis , Ramírez-Sanabria Andrés David , Mejía-Michelsen Isabella , Camargo Julian , Araque Yessid , Pedraza María Camila , Mendoza Juliana , Fonseca Pierre , Ramírez-Arquez Ericka , Nicolas Campo Teo , Quiñones-Ossa Gabriel Alexander , Mattar M. Salvador , Davidson Juan Sebastian , Gómez-Amarillo Diego Fernado , Mejía Cordovez Juan Armando , Hakim Daccach Fernando , Ramon Cuellar Juan Fernando , Jimenez Hakim Enrique
Published: November 2024

BACKGROUND AND OBJECTIVES:

Surgical site infections (SSI) in neurosurgery result in prolonged hospitalizations, readmissions, poor outcomes, and even death. Prevention of SSI remains paramount to mitigate the risk of this complication. In this study, we aimed to evaluate the effect of topical use of vancomycin powder during surgical closure in cranial surgery for the reduction of SSI.

METHODS:

This is a retrospective cohort study of cranial neurosurgical patients from 2016 to 2022 in Fundación Santa Fe de Bogotá. Baseline clinical and surgical characteristics were collected, as well as vancomycin powder use. The primary outcome of interest was SSI within 90 days after surgery. A P value of .05 was considered significant.

RESULTS:

We found a total of 1395 patients, of which 1108 met the selection criteria. Surgical site infection was seen in 32 patients (2.9%). Topical use of vancomycin powder during surgical closure was associated with a lower frequency of SSI in cranial surgery n = 10 (2.3%) relative to those who did not use vancomycin n = 22 (3.3%), and it was found to be a protective factor in the multinomial regression, with a statistically significant result (relative risk = 0.397, P = .034).

CONCLUSION:

The evidence supporting the use of vancomycin powder during surgical closure is currently weak, as the association did not reach statistical significance in the primary analysis. However, a P value of less than 0.05 was obtained in the multivariate analysis. To further assess the efficacy of this intervention, additional randomized prospective studies are needed.
Subarachnoid Hemorrhage Because of Ruptured Multiple Peripheral Fusiform Aneurysms Associated With Systemic Lupus Erythematosus: A Case Report
Authors: Hirose Yuki , Hashimoto Koji , Murase Ryota , Yoshioka Hideyuki , Wakai Takuma , Tateoka Toru , Ogiwara Masakazu , Kinouchi Hiroyuki
Published: November 2024

BACKGROUND AND IMPORTANCE:

In rare cases, systemic lupus erythematosus (SLE) can cause subarachnoid hemorrhage (SAH) because of aneurysm rupture. Such aneurysms are most commonly located in the posterior circulatory system, but can occur extremely rarely in the spinal vascular territory.

CLINICAL PRESENTATION:

We describe a patient with SLE who had a sudden onset of posterior neck pain. Cranial computed tomography and MRI showed SAH, but no aneurysm could be identified on computed tomography angiography or magnetic resonance angiography. Digital subtraction angiography (DSA) revealed multiple small fusiform aneurysms in the spinal vascular territory, which were treated conservatively without rebleeding. One year later, the patient suffered from recurrent SAH. On DSA, the fusiform aneurysms seen at the previous admission had disappeared and a de novo small fusiform aneurysm was observed in the anterior spinal artery. Conservative treatment was performed, and rebleeding was not observed thereafter. On follow-up DSA performed 2 weeks later, the aneurysm had decreased in size.

CONCLUSION:

In SLE, spinal arteriography should be performed to evaluate the possible development of peripheral fusiform aneurysms in the spinal vascular territory associated with vasculitis, and careful follow-up is necessary considering the risk of rebleeding because of de novo aneurysms.
Time-Spatial Labeling Inversion Pulse (Time-SLIP) MRI for Evaluating Cerebrospinal Fluid Velocity and Visualizing Flow Dynamics in Patients With Chiari Type I Malformation
Authors: Inoue Tatsushi , Joko Masahiro , Murayama Kazuhiro , Ikedo Masato , Saito Fumiaki , Muto Jun , Takeda Hiroki , Kaneko Shinjiro , Hirose Yuichi
Published: November 2024

BACKGROUND AND OBJECTIVES:

Phase-contrast MRI is unstable and is not widely implemented in the imaging of Chiari malformation type I (CM-I) because of its low signal-to-noise ratio and the need for subsequent additional averaging. Time-spatial labeling inversion pulse MRI (T-SLIP MRI) is an emerging imaging modality with a high signal-to-noise ratio. This study is the first to examine cerebrospinal fluid (CSF) dynamics on the basis of velocity exclusively in patients with CM-I using T-SLIP MRI before and after posterior fossa decompression.

METHODS:

Eleven patients with CM-I underwent T-SLIP MRI before and/or after posterior fossa decompression. CSF dynamics were analyzed at 5 points around the craniovertebral junction. T-SLIP measurements included (1) targeted CSF labeling; (2) manual frame-by-frame annotation of the labeled CSF wave; (3) description of CSF flow in terms of wave functions calculated using computation software; and use of this function for (4) calculation of CSF velocity (rostral and caudal peak), total distance traveled by labeled CSF, and mean CSF velocity (

). Differences between preoperative and postoperative peak velocity (rostral and caudal) and

were assessed using paired t-test.

RESULTS:

Rostral and caudal peaks significantly increased at 2 of the 5 points (40%), whereas

significantly increased at 4 points (80%), altogether covering all observation points with significant changes. CSF filling the syrinx through the syrinx wall from the spinal subarachnoid space and complex CSF flow at the dorsal craniovertebral junction were captured preoperatively and postoperatively, respectively.

CONCLUSION:

T-SLIP MRI data for patients with CM-I were successfully quantified on the basis of velocity. Tailor-made optimal decompression should be pursued based on both T-SLIP data with high accuracy and bibliographical craniometric data with surgical outcomes, which can now be easily and comprehensively analyzed using machine learning.
Analysis of Surgical Smoke Generated by Electrocautery in a Simulated Neurosurgical Operating Room Using a Postmortem Porcine Model for Laminectomy and Craniotomy Exposures: A Preliminary Study
Authors: Levy Bennett R. , Monteiro Andre , Jaikumar Vinay , Donnelly Brianna M. , Smolar David E. , Lim Jaims , Mullin Jeffrey P. , Levy Elad I.
Published: November 2024

BACKGROUND AND OBJECTIVES:

Electrocautery is a widely used tool to coagulate and separate tissue during neurosurgical procedures. Surgical smoke generated by electrocautery has harmful properties if inhaled over long-term. To our knowledge, no efforts have been made within the neurosurgery field to investigate the air quality of operating rooms (ORs) where neurosurgical procedures are being performed. We analyzed the presence and quantitation of volatile organic compounds and respirable dust in surgical smoke generated by electrocautery use during a neurosurgical OR simulation for laminectomies and craniotomies and evaluated whether surgical masks can adequately prevent inhalation of such substances.

METHODS:

Two laminectomy exposures and two bicoronal exposures were performed in two freshly euthanized pigs using electrocautery in a simulated neurosurgical OR. In each of the four neurosurgical procedure models, air sampling media and pumps were connected to a 3D-printed human face model. In two of these models, the face was covered with a standard surgical mask; in the other two models, no masks were placed. The models were positioned at a distance of 40 cm from the surgical field. Air samples were analyzed by an independent laboratory. Analyses of total amounts of respirable dust and 31 organic volatile compounds were conducted. The mean total amounts of the samples obtained from the masked and nonmasked models were compared.

RESULTS:

In the two masked and two nonmasked models, all 31 organic volatile compounds were below the levels of quantitation. The total amounts of respirable dust were higher in the two nonmasked models than in the two masked models.

CONCLUSION:

The total amount of organic volatile compounds seems to be low at the distance measured regardless of mask use; however, further studies are needed to determine whether even small amounts can be harmful over time. Standard surgical masks reduced the amounts of inhalable respirable dust.
Supplementary Motor Area Syndrome After Resection of a Dominant Hemisphere Parasagittal Meningioma: A Case Report
Authors: Walker Samantha E. , Kaoutzani Lydia , Vale Fernando L.
Published: November 2024

BACKGROUND AND IMPORTANCE:

Supplementary motor area (SMA) syndrome is a common, transient postoperative complication of intra-axial tumor resections involving the SMA and posterior cingulate gyrus. It is also reported as a rare complication of resecting extra-axial lesions. Meningiomas represent the most common, nonmalignant primary central nervous system tumor in adults, which present most commonly in parasagittal locations. Resection of dominant hemisphere parasagittal meningiomas overlying or infiltrating into the SMA region carry a recognizable risk for developing SMA syndrome postoperatively.

CLINICAL PRESENTATION:

We present a 58-year-old woman with intermittent headaches and concern for new-onset seizures. MRI demonstrated an extra-axial mass involving the left frontal convexity and SMA region with homogenous postcontrast enhancement. There was radiographic involvement of the superior sagittal sinus and inner table of the skull. Fluid-attenuated recovery signal and perilesional vasogenic edema were also noted. The imaging findings favored a parasagittal meningioma, and surgical resection was performed. Arachnoid invasion and pial infiltration of the tumor over the SMA were evident during the operation.

CONCLUSION:

A detailed understanding of the functional neuroanatomy and clinical pathophysiology of eloquent cortical regions is important for preoperative planning and patient counseling. Surgical resection of lesions in such areas can result in rare complications uniquely implicated in specific patient subsets. Recognizing these patients in the preoperative setting is imperative for proper counseling of patients and families.
Complete Clival Resorption and Pontine Pneumatosis Secondary to Severe Cocaine-Induced Midline Destructive Lesion: A Case Report
Authors: Almansouri Abdulrahman , Tham Alex , Abobotain Abdulaziz , Almarwani Mashael , Tewfik Marc , Sirhan Denis
Published: November 2024

BACKGROUND AND IMPORTANCE:

Cocaine-induced midline destructive lesions manifest as various degrees of distortion to normal anatomy. We present a rare case of substance-induced clival defect that underwent surgical repair.

CLINICAL PRESENTATION:

This patient presented with transient neurological deficits and was found to have severe clival destruction and pontine pneumatosis secondary to prolonged cocaine use. Surgical reconstruction of the clival defect was performed using a combined open and endoscopic approach.

DISCUSSION:

When anatomical integrity is severely compromised, defects of the clival region can be repaired using a hybrid open-endoscopic approach. In this case, the lack of local mucosal tissue for reconstruction led to the use of a pedicled pericranial flap.

CONCLUSION:

Complete clival resorption secondary to cocaine use is uncommon. In advanced cases, pontine inflammation is present on imaging studies. Combined endoscopic and open clival reconstruction is effective in restoring anatomic integrity.
A Novel Interhemispheric Dural Inversion Technique for Indirect Parafalcine Cerebral Revascularization: Case Report
Authors: Atai Nadia A. , Nguyen Vincent N. , Kammen Alexandra , Sternbach Sarah , Rennert Robert C. , Russin Jonathan J.
Published: November 2024

BACKGROUND AND IMPORTANCE:

Variety of revascularization strategies have been deployed to treat the deterioration of cerebral blood flow. Blood flow restoration can be achieved by direct or indirect procedures. The indirect reconstructive procedure to augment blood flow involves encephalomyosynangiosis, encephaloduroarteriosynangiosis, or encephalodurosynangiosis, and has been used effectively in ischemic Moyamoya disease. However, the preferred procedure must be evaluated on a case-by-case basis and remains controversial in other cerebral arterial diseases. Here, we report the “interhemispheric dural inversion (IDI)” as a novel technique for indirect parafalcine cortical revascularization.

CLINICAL PRESENTATION:

A 54-year-old white man with a complex history of neck radiation secondary to childhood Hodgkin's lymphoma presented with focal perfusion deficit in the right mesial occipital lobe near the primary visual cortex. A large c-shaped dural flap with a paramedian base is harvested and, after an interhemispheric dissection, placed in contact with the ischemic parafalcine cortical tissue (IDI).

CONCLUSION:

The IDI was used successfully for indirect revascularization of a focal right paramedian occipital lobe deficit in a 54-year-old man with complex cerebro-occlusive disease from childhood radiation and multiple previous bypass surgeries. The IDI is a simple approach for targeted indirect parafalcine cortical revascularization to facilitate an increased blood supply and prompt new vessels to sprout from preexisting dural arteries. It can be used as a standalone technique or combined with other revascularization strategies, as warranted.
A Hybrid Approach for the Treatment of a Pure Arterial Malformation Located at an Accessory Middle Cerebral Artery. Cerebral Revascularization Followed by Endovascular Occlusion Using nBCA: Case Report
Authors: Albiña-Palmarola Pablo , Kurucz Peter , Khanafer Ali , Hajiyev Kamran , Bäzner Hansjörg , Henkes Hans
Published: November 2024

BACKGROUND AND IMPORTANCE:

Pure arterial malformations (PAMs) are rare vascular lesions with unknown natural history. Described in 2013 and initially considered benign, recent evidence of ruptured cases and progressive angioarchitectural changes may support the need for interventional treatment for selected patients. We present the first case of an accessory middle cerebral artery PAM successfully treated using a hybrid approach, including microsurgical revascularization and endovascular occlusion using Glubran2/Lipiodol.

CLINICAL PRESENTATION:

A 58-year-old woman with a history of spontaneous basal ganglia hemorrhage 2 years before presented to our clinic with a dilated, multilobulated, and overlapping lesion located at a dominant left accessory middle cerebral artery, compatible with the diagnostic criteria of a PAM. The lesion was near the previous bleeding site, and since perforating and cortical vessels arose from its distal lobule, a safeguarding superficial temporal artery-MCA bypass was considered necessary before the successful endovascular embolization of the malformation using nBCA (Glubran2/Lipiodol).

CONCLUSION:

PAMs can be associated with intracranial bleeding; thus, active treatment is warranted for selected patients. A hybrid microsurgical-endovascular approach is feasible and can be considered the optimal treatment for specific complex anatomies.
Multimodal and Repeated Localization of Primary Hand Motor Function to the Lateral Postcentral Gyrus in a Case of Frontal Motor Area Brain Metastasis
Authors: Boerger Timothy F. , DeGroot Andrew L. , Schwartz Stephanie , Botros Nada , Schmit Brian D. , Krucoff Max O.
Published: November 2024

BACKGROUND AND IMPORTANCE:

The human motor homunculus is a well-known topographical map of the functional-anatomical relationships of the precentral gyrus. Within this homunculus, the primary hand motor area is considered one of the least plastic functional-anatomical relationships. Only a few cases in the literature describe relocation of functional hand representation away from the classical anatomical location. These cases have been reported in the context of children, primary gliomas, or arteriovenous malformations.

CLINICAL PRESENTATION:

Here, we describe a unique case where the area of lowest hand motor stimulation threshold (ie, hand motor representation) was found in the postcentral gyrus in an older adult with a metastasis in the premotor area of the brain. This localization was based on intraoperative cortical stimulation–evoked motor potentials and confirmed with electrophysiological phase reversal and MRI-based neuronavigation. This mapping was repeated and consistent 2 months later during a reoperation for recurrence. In addition, the remapped anatomical location was found in an area that was active during finger tapping on preoperative functional MRI.

CONCLUSION:

These findings suggest that neuroplastic remapping of hand motor cortex to the postcentral gyrus can occur in brain metastases even in adults. This has implications for planning tumor resections and interventional neurorehabilitation strategies, and it suggests that the motor homunculus may have more plastic potential in adulthood than previously recognized.
Utilization of the Lateral Extracavitary Approach for the Resection of a Giant Extradural Paraspinal Schwannoma: A Case Report
Authors: Mozaffari Khashayar , Fleisher Max , Harris Peter , Rosner Michael K.
Published: November 2024

BACKGROUND AND IMPORTANCE:

Spinal schwannomas are benign neoplasms originating from the spinal nerve sheath and account for around one-third of primary spine neoplasms. The most common treatment modality for these tumors is complete surgical resection. Compared with intradural tumors, the resection of an extradural spinal schwannoma is generally associated with a more complex approach, including longer incisions and increased lateral exposure. One useful surgical technique is the lateral extracavitary approach (LECA), which enables dorsal and ventrolateral access to the thoracolumbar spine with decreased rates of morbidity. Herein, the authors describe this approach for the resection of a giant extradural paraspinal schwannoma.

CLINICAL PRESENTATION:

A 74-year-old female patient presented with right flank pain and difficulty breathing during strenuous exercise. Imaging revealed a large 8.5 × 5.2 × 6.3 cm solid paraspinal lesion spanning from T11-L2 vertebral body levels, with mass effect on the right posterior diaphragm and lung. Before surgical resection, the lesion was confirmed to be a schwannoma by needle biopsy. A LECA approach was used, achieving gross total resection. At 1-month follow-up, the patient reported great symptomatic resolution.

CONCLUSION:

LECA proved to be an instrumental approach in a technically challenging resection of a giant extradural paraspinal schwannoma.
The Usefulness of Vascularized Flap Craniotomy for Open-Wound Depressed Skull Fractures
Authors: Nakahara Yoichiro , Kikuchi Jin , Kotaki Yoshikuni , Otsu Yusuke , Sugi Keisuke , Yoshitake Hidenobu , Negoto Tetsuya , Morioka Motohiro
Published: November 2024

BACKGROUND AND IMPORTANCE:

Free bone flap craniotomy for open-wound depressed skull fractures poses a high risk of infection due to free bone fragments. This risk escalates in the presence of compound fractures with accompanying dural injuries. The primary objectives in managing depressed skull fractures include infection prevention and the correction of cosmetic deformities. This report describes the efficacy of vascularized flap craniotomy, which preserves blood flow to bone fragments, in reducing infection risks.

CLINICAL PRESENTATION:

In this study, we present a 54-year-old man with a head injury and a Glasgow Coma Scale score of 8. He had an open wound in the left parietal temporal area and depressed skull fractures with compound bone fragments. The patient underwent vascularized flap craniotomy, focusing on maintaining blood supply to the bone fragments, resulting in successful wound healing without acute infections.

CONCLUSION:

Vascularized flap craniotomy is an effective surgical option for treating open-wound depressed skull fractures, potentially reducing the risk of infection by maintaining blood flow to bone fragments. Further studies are required to validate its efficacy in larger patient populations.
Endovascular Embolization Through Grafts for Recurrent Giant Complex Internal Carotid Artery Aneurysms After Combined Microsurgical Low-Flow With Subsequent High-Flow Revascularization and Parent Artery Occlusion
Authors: Nurimanov Chingiz , Menlibayeva Karashash , Mammadinova Iroda , Nurakay Nurtay , Makhambetov Yerbol
Published: November 2024

BACKGROUND AND IMPORTANCE:

The case describes the management of a giant and recurrent aneurysm in a patient. The treatment involved a combination of microsurgical protective low-flow, followed by high-flow revascularization and parent artery occlusion.

CLINICAL PRESENTATION:

The patient presented with severe headaches and progressive visual impairment. Brain magnetic resonance imaging revealed a giant saccular intracranial aneurysm in the left internal carotid artery. The examination also revealed hypoplasia of the right anterior cerebral artery and a fetal-type left posterior cerebral artery originating from the neck of the aneurysm. Considering the location and size of the aneurysm, a combination of endovascular and microsurgical approaches was applied. A protective low-flow procedure was followed by high-flow revascularization and occlusion of the parent artery. After 12 months, the aneurysm recanalized through the graft. To address the recurrence of giant complex aneurysms, endovascular embolization was performed through the radial artery grafts. These interventions showed positive midterm outcomes for the patient's giant aneurysm.

CONCLUSION:

In the treatment of complex giant aneurysms, it is important to consider both endovascular and microsurgical approaches as complementary, rather than mutually exclusive. Endovascular embolization using radial artery grafts may be used when dealing with retrograde recanalization and the challenges associated with accessing the aneurysm.
‘Iterative Bleaching Extends Multiplexity’ facilitates simultaneous identification of all major retinal cell types
Authors: Kothurkar Aanandita A. , Patient Gregory S. , Noel Nicole C. L. , Krzywańska Aleksandra M. , Carr Brittany J. , Chu Colin J. , MacDonald Ryan B.
Published: November 2024

To understand the multicellular composition of tissues, and how it is altered during development, ageing and/or disease, we must visualise the complete cellular landscape. Currently, this is hindered by our limited ability to combine multiple cellular markers. To overcome this, we adapted a highly multiplexed immunofluorescence (IF) technique called ‘Iterative Bleaching Extends Multiplexity’ (IBEX) to the zebrafish retina. We optimised fluorescent antibody micro-conjugation to perform sequential rounds of labelling on a single tissue to simultaneously visualise all major retinal cell types with 11 cell-specific antibodies. We further adapted IBEX to be compatible with fluorescent transgenic reporter lines, in situ hybridisation chain reaction (HCR), and whole-mount immunofluorescence (WMIF). We applied IBEX at multiple stages to study the spatial and temporal relationships between glia and neurons during retinal development. Finally, we demonstrate the utility of IBEX across species by testing it on the turquoise killifish (Nothobranchius furzeri) and African clawed frog (Xenopus laevis) to glean large amounts of information from precious tissues. These techniques will revolutionise our ability to visualise multiple cell types in any organism where antibodies are readily available.
Świat z perspektywy sztuki, sztuka w perspektywie świata. #Środowisko. Tom 5
Authors: Jaworski Marcin , Cieślikowska Joanna
Published: November 2024

Scientific monograph Świat w perspektywie sztuki, sztuka w perspektywie świata #Środowisko (The World in the Perspective of Art, Art in the Perspective of the World #Environment) is the fifth volume of the publishing series of the Faculty of Fine Arts of the Nicolaus Copernicus University in Toruń. The study contains texts on broadly understood culture, art and artistic education and meets the need to create a space for the presentation of views and exchange of experiences among the scientific and artistic community. The presented texts reflect the diversity of this environment, which is created by artists, art theorists, educators and teachers. This is reflected in the multitude of topics discussed from different points of view and perspectives. The integrative dimension of this publication should be emphasised, offering a group of practitioners and theoreticians interested in art and artistic education the opportunity to share modern concepts, interesting ideas, analyses, research results, significant artistic and scientific achievements, and innovative working methods. It is worth noting in this context that the main theme of this volume is the environment. Hence, the reflection on the broadly understood environment: artistic, social, cultural, media, natural, understood as a challenge, but also an inspiration for contemporary art and artistic education.
Świat z perspektywy sztuki, sztuka w perspektywie świata. #Rysunek. Tom 4
Authors: Jaworski Marcin , Cieślikowska Joanna
Published: November 2024

Scientific monograph Świat w perspektywie sztuki, sztuka w perspektywie świata #Rysunek (The World in the Perspective of Art, Art in the Perspective of the World #Drawing) is the fourth volume of the publishing series of the Faculty of Fine Arts of the Nicolaus Copernicus University in Toruń. Both the previous volumes and the current one aim to create a convenient space for the creative exchange of views, opinions and presentation of knowledge on broadly understood culture, art and education by representatives of the scientific, artistic and educational communities. What distinguishes this volume is the main theme, which is the issue of broadly understood drawing. Representatives of various scientific disciplines and fields of art, as well as authors who moved freely on the borders of these fields, commented on this topic. In addition, researchers from different generations – those who shared their many years of artistic, scientific or educational experiences, as well as young scientists, artists and teachers who are just looking for their artistic and research paths – spoke up in the articles. The chapters presented in the volume revolve around three main thematic areas, which constitute three parts of the monograph. The first part – Drawing in the perspective of artistic practice – concerns the drawing work of selected artists. The second one – Drawing in the perspective of art and creative biography – contains reflections of artists, art theoreticians and educators on the place of drawing as an artistic and biographical experience. The third part – Drawing in the perspective of education – is the voice of theoreticians and practitioners of artistic education
Technologie sztucznej inteligencji w praktyce klinicysty i naukowca w fizjoterapii i rehabilitacji
Authors: Mikołajewska Emilia
Published: November 2024

Technologie inteligencji obliczeniowej prowadzą do przełomu w sposobie oferowania oddziaływań terapeutycznych w rehabilitacji i fizjoterapii, w tym w ramach personalizowanej medycyny prewencyjnej ludzi zdrowych. Pandemia pokazała, że nowoczesna diagnostyka, leczenie, rehabilitacja i opieka nie są w pełni możliwe bez wsparcia nowoczesnych technologii, a w szczególności sztucznej inteligencji (ang. Artificial Intelligence – AI). Obszarami oddziaływania technologii AI w rehabilitacji i fizjoterapii są: -      diagnostyka (sztucznointeligentna analiza chodu, ruchu kończyn górnych, jakości życia), -      nowatorskie systemy motywowania pacjenta do ćwiczeń, w tym poprzez wykorzystanie rzeczywistości wirtualnej (VR) i rzeczywistości rozszerzonej (AR), -      kreatywne łączenie oddziaływań terapeutycznych, optymalizacja oddziaływań, -      monitorowanie realizacji ćwiczeń, -      personalizowana ocena efektywności procesu terapeutycznego, -      wykorzystanie egzoszkieletów i robotów rehabilitacyjnych, -      boty jako narzędzia diagnostyczne i wspomagające terapię, -      telerehabilitacja i rehabilitacja hybrydowa, -      inteligentne środowiska terapeutyczne, -      pomiar wpływu terapii na czynności codziennego życia i jakość życia, -      modele obliczeniowe procesów terapeutycznych, -      ocena klinicznej przydatności rozwiązań AI, -      oprogramowanie medyczne wykorzystujące AI jako wyrób medyczny zgodnie z dyrektywą MDR oraz ISO 13485, -      etyka sztucznej inteligencji z punku widzenia klinicysty. Monografia prezentuje zagadnienia o wysokim poziomie naukowym i istotnym znaczeniu kliniczny, a przez to ważne dla rozwoju nauki i wzrostu polskiej gospodarki poprzez poprawę zdrowia społeczeństwa, w tym: -      poprawę profilaktyki u osób zdrowych w ramach medycyny prewencyjnej, -      poprawę wczesnej diagnostyki zmian patologicznych,  -      zwiększenie skuteczności rehabilitacji,  -      zmniejszenie liczby osób czasowo lub trwale niepełnosprawnych,  -      dłuższe utrzymanie sprawności osób w podeszłym wieku.
Komedia według Terencjusza
Authors: Skwara Ewa
Published: November 2024

Terencjusz – podstawowa lektura szkolna całej starożytności, średniowiecza, odrodzenia; źródło inspiracji dla komedii chrześcijańskiej, teatrów konwiktowych, dramy mieszczańskiej; wzór eleganckiej łaciny jej kolokwialnym rejestrze; skarbnica sentencji… Terencjusz stał się tak popularny, że przestał interesować badaczy, wydawało się bowiem, że nie można już nic powiedzieć, co nie zostałoby powiedziane wcześniej A jednak ostatnie dwie dekady przyniosły prawdziwy renesans w badaniach nad tym poetą, a w konsekwencji nowe, niekiedy zaskakujące odczytanie jego komedii. Nawet skąpe informacje o życiu i walce o scenę zyskały w tym świetle odmienne niż dotąd oblicze. Oddawana do rąk czytelnika monografia stara się zaprezentować całe to spektrum interpretacji wraz z propozycjami autorki. Terencjusza najbardziej interesuje człowiek, jego osobowość, charakter, zalety i przywary, ale także reakcje na uwikłanie w codzienne i niecodzienne problemy. Nie bez powodu mówi się, że każda ze sztuk to wnikliwe studium psychologiczne. Dlatego monografia najwięcej miejsca poświęca temu właśnie zagadnieniu. Stara się także pokazać, że Terencjusz nawet nie próbuje konkurować ze swoim poprzednikiem – Plautem, nie pociąga go powielanie schematów fabularnych, a jedynie ich przetwarzanie. Wyraźnie widać, że nie chce naśladować, przeciwnie – ucieka od ustanowionego przez Plauta wzorca, szukając dla siebie nowych, bo zmodyfikowanych, form zgranych już motywów. Monografia weryfikuje także dotychczasowe ustalenia w dziedzinie języka i metryki. Podkreśla, że sztuki Terencjusza pełne są barwnej metaforyki, nie stronią od obscenicznych skojarzeń, postaci nie mówią tak samo, a wykorzystane metra w specyficzny sposób wspierają fabułę oraz wzmacniają wizerunki bohaterów. Nowa monografia to nowe oblicze Terencjusza.
W cieniu Dżesera. Badania polskich archeologów w Sakkarze
Authors: Myśliwiec Karol
Published: November 2024

Monografia „W cieniu Dżesera. Badania polskich archeologów w Sakkarze” jest syntezą osiągnięć naukowych polsko-egipskiej misji archeologicznej prowadzonej od 1987 roku wykopaliska po zachodniej stronie piramidy, tzw. piramidy schodkowej, zbudowanej w początkach III dynastii (ok. 2650 rok p.n.e.) przez legendarnego architekta i imieniu Imhotep. Misją kieruje autor książki. Efektem dwudziestu dotychczasowych kampanii wykopaliskowych było odkrycie dwu cmentarzysk z epok odległych od siebie o dwa tysiąclecia: nekropolii wielmożów ze schyłkowej fazy tzw. Starego Państwa (ostatnie stulecia III tysiąclecia p.n.e.) i Okresu Ptolomjskiego (trzy ostatnie stulecia I tysiąclecia p.n.e.) Starsza z dwu nekropol, położona w warstwie dolnej, zawiera dziesiątki grobowców, których część podziemna została wykuta w stopniach skalnych wcześniejszego kamieniołomu, z którego czerpano materiał do budowy kompleksu grobowego Dżesera. Kaplice kultowe najstarszych spośród odkrytych tu mastab zawierają unikatową dekorację ścienną, tj. płaskorzeźby i malowidła wzbogacające naszą wiedzę o sztuce egipskiej tego okresu, a będące jednocześnie cennymi źródłami do poznania historii tych burzliwych czasów, kiedy znakomicie zorganizowane państwo faraonów chyli się po raz pierwszy ku upadkowi. Zachowane teksty hieroglificzne i przedstawienia figuralne, m.in. sceny polowań i bankietów, a także „portrety rodzinne” pozwalają wniknąć w atmosferę konfliktów politycznych i rodzinnych, w jakie obfitowało życie codzienne tamtego okresu. Górna warstwa badanego terenu zawiera natomiast setki pochówków w formie mumii spowitych najczęściej bogato dekorowaną powłoką zwaną kartonażem. Przesłanki topograficzne i ikonograficzne pozwalają wnioskować, że to cmentarzysko powstało w bezpośrednim sąsiedztwie pierwszego, prowizorycznego grobu Aleksandra Wielkiego, zanim jego mumie przeniesiono do Aleksandrii. Autor prezentuje też techniki archeologiczne i różne sposoby dochodzenia do prawdy historycznej na podstawie fragmentarycznie zachowanych źródeł. Jeden z rozdziałów jest poświęcony pracom polskich konserwatorów, które stanowią integralną część programu badawczego. Opis prac wykopaliskowych obfituje w anegdoty z życia misji.
Orgie słów. Terminologia misteriów w "Parafrazie Ewangelii wg św. Jana" Nonnosa z Panopolis
Authors: Doroszewski Filip
Published: November 2024

Książka poświęcona jest terminologii misteriów w epickiej Parafrazie Ewangelii wg św. Jana napisanej przez Nonnosa z Panopolis. Temat ten jest podwójnie tajemniczy. Postać Nonnosa, późnoantycznego poety greckiego z Egiptu, który najprawdopodobniej żył i tworzył w kosmopolitycznej Aleksandrii w V w. n.e., do dziś pozostaje zagadką. Niemal wszystko, co możemy o niej powiedzieć jest wynikiem naukowej spekulacji. Jest to tym bardziej frapujące, że Nonnos uznawany jest za jednego z najważniejszych poetów późnej starożytności, a jego spuścizna literacka, która oprócz Parafrazy obejmuje też monumentalny epos poświęcony Dionizosowi, greckiego bogu wina, misteriów i rytualnej ekstazy, traktowana jest dziś jako swoista summa antycznej kultury. Nie mniej zagadkowe pozostają same starożytne misteria, sekretne kulty bóstw, w których uczestniczyć mogli jedynie wtajemniczeni. Ich treść otoczona była ścisłą tajemnicą, która do dziś pozostaje w dużej mierze nieprzenikniona, wiemy jednak, że niosły one obietnicę lepszego losu za życia i po śmierci. Nie może więc dziwić, że terminologia związana z inicjacją w misteryjne obrzędy, a zwłaszcza w najsłynniejszy kult sprawowany w Eleusis ku czci Demeter i Kore oraz w bardzo rozpowszechnione misteria Dionizosa, stała się w literaturze antycznej uniwersalną metaforą dążenia ku temu, co prawdziwie boskie. Decydująca rola w upowszechnieniu tej metafory przypadła dialogom platońskim, które niezwykle sugestywnie przedstawiają uprawianie filozofii jako wtajemniczenie w misteria. Przenośnie użyta terminologia misteryjna powraca potem nie tylko u autorów pogańskich, lecz przenika także do zhellenizowanego judaizmu i antycznego chrześcijaństwa, gdzie znajduje szeroki użytek w egzegezie Biblii. Istotną rolę pełni również w Parafrazie Nonnosa z Panopolis.
W sercu Ultima Thule. Reprezentacje Grenlandii Północnej w relacjach z ekspedycji Knuda Rasmussena
Authors: Lubowicka Agata
Published: November 2024

Prezentowana książka to próba odczytania nieznanych w Polsce relacji z ekspedycji na Grenlandię Północną najznamienitszego duńsko-grenlandzkiego polarnika, Knuda Rasmussena. Celem autorki jest zbadanie związków literackiej konstrukcji tych terenów z procesem kolonialnym, w wyniku którego cały region Thule został objęty zwierzchnością państwa duńskiego. Przyjmując za punkt wyjścia ambiwalencję zarówno postaci polarnika, jak i literackich przedstawień omawianego obszaru oraz jego rdzennych mieszkańców, autorka dowodzi niestabilności konstrukcji geografii i tożsamości, mimo asymetrycznego układu sił między kolonizatorem a skolonizowanym.
Code and Data Repository for A New Approximation Algorithm for Minimum-Weight (1,m)–Connected Dominating Set
Authors: Zhou Jiao , Ran Yingli , Pardalos Panos M. , Zhang Zhao , Tang Shaojie , Du Ding-Zhu
Published: November 2024

The goal of this repository is to demonstrate the efficiency of our algorithm for Minimum-Weight ( 1 , m ) --Connected Dominating Set.
The Blockchain Newsvendor: Value of Freshness Transparency and Smart Contracts
Authors: Keskin N. Bora , Li Chenghuai , Song Jing-Sheng
Published: November 2024

Motivated by blockchain applications in the fresh produce industry, we consider a newsvendor problem in which a retailer faces stochastic and freshness-dependent consumer demand. The retailer can adopt blockchain technology to have more transparent information on the freshness of supply. We quantify the value of blockchain-enabled freshness transparency by deriving closed-form expressions for the retailer’s expected profit growth and food waste reduction brought by blockchain adoption. Using publicly available data, we provide a numerical example illustrating that for Walmart’s strawberry business in the United States (which is about only 4% of Walmart’s fresh produce sales), blockchain can increase annual profit by [Formula: see text] million while eliminating 23 million pounds of food waste annually through operational improvements. Despite this substantial value for the retailer, blockchain adoption can decrease the expected profit of the retailer’s supplier. We design a family of threshold-type smart contracts contingent on a blockchain-based freshness consensus and examine when such contracts offer a win-win proposition to the retailer and the supplier. Moreover, when the retailer offers freshness-based price discounts, we find that less fresh supply leads to less food waste. In contrast, when the supplier adjusts the wholesale price based on freshness, less fresh supply causes more food waste. We also generalize our findings to the cases of (i) dual sourcing, (ii) noisy measurements in the Internet of Things sensors feeding data into blockchain, and (iii) the retailer’s culling processes.

This paper was accepted by David Simchi-Levi, operations management.

Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2021.02949 .
The Impact of Human Parainfluenza Virus on Child Health: A Clinical Study
Authors: Kalaycı Furkan , Karaköse Ece , Çırak Ayça , Yiğit Metin
Published: November 2024

Objective: This study aims to identify the clinical characteristics of Human Parainfluenza Virus (HPIV) infections in children, evaluate morbidity and mortality rates, and investigate the impact of chronic diseases on the course of these infections.

Material and Methods: The research was conducted retrospectively and cross-sectionally on children aged 0-18 who tested positive for HPIV in the respiratory viral panel at Ankara Bilkent City Hospital Children’s Hospital between August 2019 and July 2023. Patients with multiple virus positivity were excluded from the study.

Results: The study included 160 patients, of whom 61.2% were male and 38.8% were female. The most common presenting symptoms were cough (66.3%) and fever (52.5%). Of the patients, 41.2% were treated as inpatients, and 19.6% received care in the intensive care unit. The need for invasive or noninvasive mechanical ventilation was observed in 10% of the patients. There was a statistically significant association between the presence of lung infiltration and chronic disease with hypoxia (p < 0.001).

Conclusion: While HPIV infections are generally mild, they can lead to significant morbidity and the need for intensive care in children with chronic diseases. These findings highlight the necessity for careful clinical evaluation and close monitoring of children with HPIV infections. The study’s results may contribute to the management and treatment strategies for HPIV infections in the pediatric population.
Activities of living: expressing sexuality
Authors: Peate Ian
Published: November 2024

This article discusses the complexity of care provision related to the expression of sexuality, the tenth activity of living in Roper et al's (2000) model. Sexuality encompasses the physical, psychological, social and spiritual aspects of health. Discussing sexuality in an appropriate and sensitive way can enable healthcare assistants and assistant practitioners to foster a comprehensive understanding of patients' needs. Furthermore, the article highlights the importance of cultural competence and ethical considerations in delivering sensitive sexual care. Recognising sexuality as an integral aspect of human experience can lead to better patient-centred care, promotion of sexual health and a meaningful contribution to the holistic wellbeing of individuals.
The care certificate: communication
Authors: Ellis Peter
Published: November 2024

This article provides an overview of what healthcare assistants need to understand about communication, the sixth standard of the care certificate.
ARCTIC ENVIRONMENT IN DEFIANCE TO FAST-TRACK OPERATIONS ON HIP FRACTURES: A CHALLENGE ENLIGHTED
Authors: Hansen E. C. , Christensen S. , Simony A. , Damborg F. , Andersen S.
Published: November 2024

Introduction

Most western countries have implemented fast-track hip fracture aiming at surgery within 24 hours, since the mortality rate hereafter rises markedly.

In Greenland, it is not achievable to operate within 24 hours. Arctic people live in sparsely populated areas and Greenland's population is scattered along the vast coastline. All patients must be chartered to Nuuk by airplane which can take up till several days to weeks, due to logistics and the Arctic weather. This presents a challenge regarding adhering to western guidelines. The operative delay may be acceptable though, as it is the impression that the Greenlandic population survives and endures better than patients of western populations.

However, as data are lacking, we aimed to describe mortality among hip fracture patients in Greenland taking frailty and comorbidities into account.

Method

All patients with ICD-10 codes DS720, DS721 and DS722 from 2018-2022 were identified as 261 patients diagnosed with hip fractures. Variables including time of diagnosis, time to operation, reasons for delay, ASA-score, Charlson Comorbidity index, time of death, and other possible confounding variables were analyzed. Primary outcome was mortality rates at 30-day post-OP and 1-year post-OP.

Results

The average time from fracture to operation was 91.4 hours. In the Danish Cohort (DC) 70,6 % of patient were operated within 24 hours. Overall, 30-day mortality was 9,9 %, and 1-year mortality was 29,4 %, compared to the DC with 10,8 % 30-day mortality and 28,3 % 1-year mortality.

Multivariate regression was conducted, showing no statiscal significant increase in mortality, despite extended delay.

Conclusion

With no increase in death, the authors find it justifiable that patients in Greenland endure longer delays than the western population. The influence on further adverse effects needs to be investigated as well as causes of survival, but perhaps the Arctic people unveil mechanisms for raised survival among other populations.
BONE PEG-IN-BONE TECHNIQUE FOR LONG BONE NONUNIONS: A RETROSPECTIVE REVIEW
Authors: Chalak A. , Singh S. , Kale S.
Published: November 2024

Introduction

The non-union of long bones poses a substantial challenge to clinicians and patients alike. The Ilizarov fixation system and Limb Reconstruction System (LRS), renowned for their versatility in managing complex non-unions. The purpose of this retrospective study was to assess the outcomes of acute docking with the bone peg-in-bone technique for the management of non-unions of long bones. The study seeks to evaluate its effectiveness in achieving complete bony union, preserving limb length and alignment, correcting existing deformities, and preventing the onset of new ones.

Method

A retrospective analysis of 42 patients was done with infected and non-infected non-unions of long bones who received treatment at a tertiary care hospital between April 2016 to April 2022. We utilized the Association for the Study and Application of Methods of the Ilizarov (ASAMI) scoring system to assess both bone and functional outcomes and measured mechanical lateral distal femoral angle (mLDFA) for the femur and the medial proximal tibial angle (MPTA) for the tibia.

Result

In our retrospective study involving 42 patients, a total of 30 patients had post debridement gap of >2 cm and average gap of 4.54 cm (range 1 – 13 cm) and therefore underwent corticotomy and lengthening. The average external fixation time was 6.52 (range 4 – 11 months) and average external fixation index of 2.08 (range 0.4 – 4.5 months/cm). The ASAMI scoring system showed bone result of 38 excellent, 3 good and 1 fair. Functional result of 40 excellent and 2 good outcomes. The post op mLDFA and MPTA were in normal range except in 3 patients which not statistically significant.

Conclusion

In conclusion, the use of acute docking provides several advantages such as promoting early fracture healing, increasing stability, shortening treatment time, reducing the number of surgical procedures and reduced number of complications.
BIENNIAL EXPERIENCE OF ROBOTIC TECHNOLOGIES, ARTIFICIAL INTELLIGENCE, AND TELEREHABILITATION IN KNEE PROSTHETICS: ANALYSIS, CORRELATIONS, AND FUTURE PROSPECTS
Authors: Panzera R. M.
Published: November 2024

Introduction

Orthopedics is experiencing a significant transformation with the introduction of technologies such as robotics and apps. These, integrated into the post-operative rehabilitation process, promise to improve clinical outcomes, patient satisfaction, and the overall efficiency of the healthcare system. This study examines the impact of an app called Mymobility and intra-operative data collected via the ROSA® robotic system on the functional recovery of patients undergoing robot-assisted knee arthroplasty.

Method

The study was conducted at a single center from 2020 to 2023. Data from 436 patients were included, divided into “active” patients (active users of Mymobility) and “non-active” patients. Clinical analyses and satisfaction surveys were carried out on active patients. The intra-operative parameters recorded by ROSA® were correlated with the Patient-Reported Outcome Measures (PROMs) collected via Mymobility

Result

Intra-operative data showed significant correlations with PROMs for the 48 active patients, highlighting the importance of parameters such as medial joint space and ligament laxity. No significant differences were observed between the sexes, but a positive correlation was detected between age and PROMs. The data analysis indicated that an increased medial joint space and reduced ligament laxity are associated with better PROMs. The adoption of Mymobility remained limited, with only 10% of patients fully utilizing the app. Critical factors have been identified to improve recruitment, engagement, and overall experience with the platform.

Conclusion

The integration of technologies such as Mymobility and ROSA® in post-operative rehabilitation offers numerous advantages, including the objectification of data, active patient involvement, and personalized care. Challenges remain related to costs, patient compliance, and demographic limitations. Nevertheless, these technologies represent a milestone in modern peri-operative management, being able to improve clinical outcomes and the quality of care.