bluuebunny/crossref_metadata_2025 huggingface dataset:
INFLUENCE OF VARIOUS FACTORS ON SPORTS RESULTS IN WHEELCHAIR MOTOCROSS
Authors:   Ivan Boberskyi Lviv State University of Physical Culture, RYBAK Oleg , VYNOGRADSKYI Bogdan ,   Ivan Boberskyi Lviv State University of Physical Culture, SKALSKI Dariusz W. ,   Jędrzej Śniadecki Academy of Physical Education and Sport in Gdańsk, RYBAK Lyudmila ,   Ivan Boberskyi Lviv State University of Physical Culture
Published: May 2024

The aim of the work is to determine the rating of the impact of various components of the provision and implementation of high sports performance of cross-country crews on motorcycles with wheelchairs. Ten experts were involved in the expert evaluation, including four specialists in the theory and methodology of motorcycle sports, three coaches and three highly qualified athletes. On a ten-point scale, they assessed the impact of four main factors, followed by the respective units of each. Experts identified motocross-specific skills and psychophysiological qualities of crew members (9.0 ± 1.1 points) as the most influential on sports results. Behind them are the technical capabilities of the motorcycle and the level of various sections of sports training of athletes (8.1 ± 1.3 and 7.8 ± 0.6 points, respectively). The specifics of the track and the conditions of the competition were rated the lowest (4.6 ± 0.5 points). Among motocross-specific skills and qualities of athletes, experts preferred the interaction and coordination of crew members (25%); their psychological readiness and stress resistance and the level of development of psychophysiological qualities were slightly lower (21 and 18%, respectively), and applied acrobatic and engineering training, as well as sports qualifications were less influential (14, 13 and 9%, respectively). The impact on the sports result of different technical characteristics of the motorcycle is estimated approximately the same, which requires its comprehensive training. Separate sections of classical sports training by their influence on the result are located as follows: SFP (23%), sports and technical (21%), functional (19%) and tactical (18%). The impact on the result of ZFP is estimated at 12%, and anthropometric indicators of athletes - only 7%. Regarding the route and weather conditions, the undisputed leader (24%) was the compliance of the route with the individual preferences of the crew; 19% of points scored the position at the start. The type and condition of the route (15%) and climatic conditions (14%) affect the final result of the crews less, and the geolocation and complexity of the route profile (10%), as well as warm-up before the start (8%), according to experts, have it has the least impact.
A Compendium on Non-native Organisms of India
Authors: K V Jayachandran , S Sheela , Anand Jasmine , Haridas Vinod
Published: May 2024

This book is a comprehensive account on the non-native organisms reported from India. Alien species introductions are rated as a major threat to biodiversity in the world next to habitat destruction. The book provides useful information on the subject, such as terminologies in use under this category, pathways of invasions, history of introductions of aquatic species, processes of introductions, consolidated data on the non-native organisms in India, non-native aquatic plants, non-native wet land plants of India, non-native terrestrial plants of Kerala, non-native crustaceans and their threat status, surveys conducted at Asramam Biodiversity Heritage Site and also T K Madhava Memorial College and nearby areas, and information about 144 plants and animals and their illustrations. Chapters on updated policy and Pontederia crassipes von Martius, 1824 (= Eichhornia crassipes (Martius, 1824) are special attractions.
Pemanfaatan ChatGPT dalam Meningkatkan Keterampilan Menulis/Maharah Kitabah Berbasis 6C (Critical Thinking, Creativity, Collaboration,Communication, Computational and Compassion)
Authors: Yasmar Renti , Suja Aidillah , Hidayat Ahmad Fadhel Syakir
Published: May 2024

ChatGPT dengan kemampuannya dalam menghasilkan teks dengan sistematika yang baik memunculkan perdebatan tersendiri di kalangan pakar pendidikan. Baik berupa dukungan maupun kekhawatiran yang berujung penolakan akan teknologi AI ini. Penelitian ini melihat peluang pemanfaatan ChatGPT dalam meningkatkan keterampilan menulis/maharah kitabah berbasis 6 C (Critical Thinking, Creativity, Collaboration,Communication, Computational  and Compassion). Metode penelitian yang digunakan yaitu desain eksperimen quasi dengan pretest-posttest design dan angket untuk mengumpulkan data tanggapan mahasiswa. serta menggunakan teknik analisis data kuatitatif dan kualitatif.  Penelitian diawali dengan memaparkan langkah-langkah eksperimen pemanfaatan ChatGPT dalam meningkatkan keterampilan menulis/maharah kitabah berbasis 6C Critical Thinking, Creativity, Collaboration,Communication, Computational  and Compassion.
Hasil dari penelitian ini adalah (1) terdapat perbedaan yang cukup signifikan dari nilai pretest yang lebih kecil dibandingkan nilai posttest 50,45 < 81,50, (2) berdasarkan rumus N-gain terdapat peningkatan sekitar 62,6% dari skor pre-test ke post-test dengan kategori cukup meningkat. Berdasarkan analisa data yang dilakukan, diperoleh kesimpulan bahwa pemanfaatan ChatGPT cukup efektif dalam meningkatkan keterampilan menulis / maharah kitabah berbasis 6 C. Selain itu, dari hasil tanggapan mahasiswa ChatGPT memudahkan dalam menyusun dan merencanakan tulisan, ChatGPT membantu dalam meningkatkan kemampuan tata bahasa  dan struktur kalimat, ChatGPT memberikan umpan balik dalam memperbaiki tulisan, ChatGPT dapat meningkatkan kreativitas dan keberagaman gaya tulisan , serta ChatGPT membantu  mempercepat proses penulisan.
STRATEGI PEMASARAN PELAKU USAHA KOPI ARABIKA DALAM PENINGKATAN PENDAPATN MASYARAKAT DI KABUPATEN LOMBOK UTARA
Authors: Ariani Zaenafi , Ardiyansah Roni , Cikal Pratama Rezky , Astriana Yuli , Ayuliana Ayuliana
Published: May 2024

Tujuan yang ingin dicapai dari Studi Potensi Komoditi Kopi di Kabupaten Lombok Utara adalah menganalisis potensi bisnis komoditas lokal dalam upaya pengembangan ekonomi di Kabupaten Lombok Utara. Adapun hasil dari penelitian ini adalah: 1) Potensi tanaman Kopi Arabika di Kabupaten Lombok Utara terlihat dari banyaknya tamanan tersebut dibudidayakan oleh masyarakat lombok utara. Hanya saja, pengelolaan tanaman Kopi Arabika di Kabupaten Lombok Utara masih dilakukan secara tradisional, meski telah diberikan pendampingan oleh pemerintah daerah; 2) hasil Berdasarkan data pengolahan ditemukan bahwa produk/komoditi kopi adalah komoditas yang layak diinvestasikan, baik oleh masyarakat maupun pemerintah daerah; dan 3) Secara garis besar terdapat 7 aspek pembangunan yang menjadi arah pengembangan produk/komoditi Kopi yang layak investasi di Kabupaten Lombok Utara menurut skala prioritas pada masing-masing kabupaten yakni: (1) produk lokal, (2) pasar, (3) tata niaga, (4) nilai tambah, (5) kemitraan, (6) dukungan pemerintah daerah, dan (7) penerapan teknologi tepat guna
Kerjasama Bilateral Indonesia-Jerman Melalui Ekspor-Impor Kopi dan Coffee Machine
Authors: Rifandi Moh. Ilham , Ageng Prakoso Havidz
Published: May 2024

Produksi kopi di Indonesia sangat banyak, hampir setiap daerah di Indonesia memiliki lahan dan kebun kopi sangat luas, hal ini mengakibatkan Indonesia mengalami kendala dalam mengolah dan memasarkan akibat kelebihan yang diproduksi. Berbagai cara dan usaha telah dilakukan oleh pemerintah, salah satunya dengan meningkatkan nilai ekspor. Banyak negara eropa yang juga memiliki tingkat konsumsi kopi terbesar, salah satunya Jerman dengan memiliki tingkat konsumsi kopi terbesar ketiga di dunia, ini merupakan hal yang potensial bagi Indonesia sendiri. Penelitian ini bertujuan untuk mengetahui  Kerjasama Indonesia-Jerman melalui ekspor dan impor kopi dan coffee machine guna mempererat hubungan bilateral antar kedua negara. Analisis ini menggunakan metode deskriptif kualitatif. Hasil dari penelitian ini menunjukkan bahwa tingkat ekspor kedua negara pada tahun 2020-2021 mengalami perubahan yang signifikan dan dengan adanya Kerjasama kedua negara tersebut, Indonesia dan Jerman ikut berkontribusi dalam perdagangan internasional
PELAYANAN PUSAT KESEJAHTERAAN SOSIAL DALAM PENANGGULANGAN KEMISKINAN
Authors: Nazrin Nazrin , Maudy Anita , Hermalinda Siska
Published: May 2024

Penelitian  ini  bertujuan  untuk mengetahui  pelayanan  pusat  kesejahteraan  sosial (Puskesos)  dalam  penanggulangan  kemiskinan  Di  Kelurahan  Abeli  Dalam  Kecamatan Puuwatu Kota Kendari.Jenis penelitian ini adalah penelitian deskripstif kualitatif. Teknik pengumpulan data dilakukan dengan cara observasi,  wawancara, dan dokumentasi dengan informan penelitian  sebanyak 13 orang. 5 orang tim pelaksana pusat kesejahteraan  sosial (Puskesos), dan 8 orang informan tambahan, 1 orang TKSK dan 7 orang warga masyarakat penerima manfaat pelayanan Puskesos Di Kelurahan Abeli Dalam Kecamatan Puuwatu Kota Kendari.
Hasil  penelitian  menunjukkan  bahwa  pelayanan  pusat  kesejahteraan  sosial  (Puskesos) berlokasi di pemerintahan Kelurahan Abeli Dalam dengan melakukan pelayanan pusat kesejahteraan sosial pada program meliputi: Kartu Idonesia Sehat (KIS), Program Keluarga Harapan (PKH), Bantuan Pangan Non Tunia (BPNT), dan Bantuan Sosial Tunai (BST). yang dilakukan oleh Puskesos kepada masyarakat miskin yaitu: 1) mengadakan perubahan dalam bentuk kegiatan, kegiatan tersebut berupa sosialisasi. 2) membantu dalam mengatasi masalah, dengan memberikan bantuan pelayanan yang berkualitas kepada individu/keluarga/rumah tangga miskin harus memiliki prosedur yang jelas, tidak berbelit-belit, mudah dipahami, dan dilakukan. Kegiatan tersebut diantaranya; penerimaan pengaduan, pemeriksaan status calon penerima manfaat dengan proses validasi dan verifkasi data, layanan penanganan keluhan sesuai  kebutuhan  program  dalam  hal  ini  pada  program  KIS,  PKH,  BPNT,  BST,  dan penanganan rujukan. Dengan jumlah penerima KIS 700 orang, PKH 77 orang KK, BPNT 137 orang KK, dan BST 6 orang KK. Jumlah penerima layanan bagi masyarakat miskin 174 orang KK  dari  202  orang  KK.  Adapun  ditemukan  dalam  pelayanan  Puskesos  serta   manfaat pelayanan   puskesos   bagi   masyarakat   yang   dapat   memberikan   dampak   baik    untuk kesejahteraan masyarakat dan penanggulangan kemiskinan, dan berkontribusi dalam terpenuhinya hak untuk mengakses layanan kesehatan, pendidikan, bantuan sembako, dan bantuan sosial tunai dapat tercapai
PENERAPAN PELATIHAN DAN DISIPLIN KERJA DALAM MENINGKATKAN KUALITAS PELAYANAN PADA KP BEINTB
Authors: Wulandari Eka , Amri Syaiful , Hidayat Surahman , Fajariah Faizatul
Published: May 2024

Penelitian ini bertujuan untuk mengetahui bagaimana penerapan pelatihan dan disiplin kerja dalam meningkatkan kualitas pelayanan pada Kantor Perwakilan BEI NTB. penelitian ini merupakan penelitian kualitatif .menggunakan tekhik sampling snowball sampling yang merupakan bagian probability sampling.Tehnik pengambilan sample menggunakan nonprobability.metode analisis yang digunakan adalah metode analisis data kualittatif model Miles dan Hubermen.
Hasil penelitian menunjukkan bahwa bahwa pelatihan (TOT, sekolah pasar modal, klinik investasi ) yang mumpuni dan disiplin kerja juga sangat berperan penting dalam meningkatkan kualitas pelayanan yang diberikan KSPM sebagai perantara nasabah dan bursa efek. Pelatihan yang diberikan bursa efek untuk melatih mahasiswa dan karyawan inti dinilai sangat membantu peningkatan baik dari jumlah investor sampai dengan penambahan jumlah transaksi investor setiap bulan.Hal ini dapat dibuktikan dari grafik peningkatan jumlah investor pada dua tahun terakhir. Selain dari itu peneliti menemukan faktor lain yang ikut berpartisipasi dalam peningkatan kualitas sumber daya manusia sampai dengan faktor peningkatan kualitas pelayanan pada KP BEI NTB terletak pada kualitas pelatih dan banyaknya KSPM yang mulai dibentuk. Seiring dengan penambahan jumlah KSPM yang dibentuk mengakibatkan penyebaran informasi yang lebih meluas dan dapat menjangkau wilayah pelosok.Penambahan KSPM dapat diikuti dengan penambahan jumlah pelatihan rutin untuk dapat menjamin informasi yang diberikan telah sesuai dengan keadaan.
Kata Kunci : Pelatihan, Disiplin Kerja, Kualitas Pelayanan
IMPLEMENTASI PRINSIP EKONOMI ISLAM PADA PEDAGANG ASONGAN DI GILI AIR KABUPATEN LOMBOK UTARA
Authors: Mashur Mashur , Riswandi Dedi , Rafsanjani Ahmad
Published: May 2024

Penelitian ini bertujuan untuk mengetahui pelaksanaan etika yang dilakukan oleh pedagang sesuai dengan perspektif Ekonomi Islam di kawasan pariwisata Gili Air Kabupaten Lombok Utara. Metode analisis data yang digunakan dalam penelitian yaitu analisis kualitatif dengan pendekatan normatif dan sosiologis. Data penelitian diperoleh dari data primer dan data sekunder dengan teknik pengumpulan data berupa observasi, dokumentasi, wawancara. Hasil penelitian ini menunjukkan bahwa masih banyaknya pedagang asongan di Gili Air yang memahami bahkan mengimplementasikannya sesuai dengan ajaran Islam. Hal ini juga terkait karena adanya kesadaran dalam menerapkan ajaran agama dalam aktivitas sosial ekonomi (bisnis) yang akan berdampak positif pada usaha yang mereka jalankan
ANALISIS STUDI KELAYAKAN BISNIS PADA USAHA BUKET MAJAS CRAFT
Authors: Alivia Khofifatul
Published: May 2024

Abstract
The business feasibility study, market and marketing point of view is very likely to be the main factor, because market and marketing point of view determines the resistance or disappointment of an organization in business. This study aims to conduct a business feasibility study on the ajas Craft business as an evaluation and improvement from the marketing aspect. The method used in this study is a qualitative method with data collection techniques through interviews, observation, searching for documents and questionnaires to strengthen data from consumers. The results of the study show that Majas Craft fulfills the feasibility aspects both in terms of the marketing aspect. However, there needs to be an increase in the marketing strategy in terms of promotion. Research also produces business strategies that can be carried out and shows that Majas Craft has competitive and profitable business prospects
ANALISIS KELAYAKAN USAHA DARI ASPEK PEMASARAN DAN PENERAPAN BAURAN PEMASARAN: STUDI PADA TOSERBA 35 HIDAYAH
Authors: Yahya Lucky Mahesa , Radinda Ayu Putri , Asri Widya Kartika , Ilham Muhammad , Saputra Andreza Yosmi
Published: May 2024

Abstract
Analysis of Business Feasibility From Marketing Aspect and Implementation of Marketing Mix: A Study of TOSERBA 35 Hidayah. Convenience stores called TOSERBA is a type of retail that sells various family needs, especially clothing needs. In general, department stores are in the form of self-service shophouses. The department store is currently one of the most in-demand family business. Even in various areas you will find many department stores, especially crowded areas. The purpose of establishing this department store is to make it easier for consumers to get the products they want easily, and to cut time and cost. In this study, we will test the business feasibility of the 35 Hidayah department store. This department store provides a wide range of family items, both clothing and other households items. As the name implies, this department store sells goods at an even price of IDR 35,000. This business feasibility test uses a qualitative method, in which interviews are a way of collecting data. The interview was conducted directly with the owner of the 35 Hidayah department store. Feasibility study of the 35 Hidayah department store seen from marketing aspect and the application of marketing mix found that feasibility can be seen from quality of product, quality according to price, the location of store, employee skills, good services and buying and selling process. And the result show that the business is feasible.
Abstrak
Toko serba ada yang biasa dipanggil TOSERBA menjadi bagian dari jenis usaha retail yang menjual berbagai kebutuhan keluarga dan kebutuhan sandang. Pada umumnya usaha ini berbentuk swalayan. Sekarang, toserba menjadi salah satu bisnis keluarga yang paling banyak dicari bahkan dapat ditemukan dimanapun kawasan ramai. Tujuan didirikannya usaha ini adalah untuk memudahkan konsumen mendapatkan produk yang diinginkan dengan mudah, serta menghemat waktu dan biaya. Pada peneliltian ini akan dilakukan uji kelayakan usaha terhadap toserba 35 Hidayah. Toserba ini menyediakan berbagai macam kebutuhan keluarga, baik pakaian maupun kebutuhan rumah tangga lainnya. Sesuai dengan namanya, toserba 35 Hidayah menjual barang dengan harga Rp. 35.000. Uji kelayakan usaha ini menggunakan metode kualitatif dimana wawancara merupakan salah cara untuk mengumpulkan data. Wawancara dilakukan langsung dengan pemilik toserba 35 Hidayah. Pengujian kelayakan dilihat dari aspek pemasaran dan penerapan bauran pemasaran. Penelitian mendapatkan kelayakan usaha dapat dilihat dari kualitas produk, kualitas sesuai penerapan harga, lokasi toko, keterampilan karyawan, pelayanan yang baik dan proses jual beli. Hasil penelitian menyatakan bahwa toserba 35 Hidayah layak untuk dijalankan.
Sistem Informasi Pemesanan Tiket Wisata Kota Surabaya Berbasis Web Menggunakan Metode Model View Controller
Authors: Mukhlis Iqbal Ramadhani Mukhlis , Alya Rizky Natasya
Published: May 2024

– Industri  wisata  menjadi  salah  satu  pendapatan  daerah  yang  sangat  potensial  bagi  masyarakat  dan pemerintah daerah. Potensi tersebut belum terkelola dengan baik akibat minimnya penggunaan teknologi Informasi.  Informasi  wisata  alam  didaerah  Surabaya  jarang  terekpose  secara umum,  padahal  wisata  alam  disana  begitu  banyak  dan  menarik.  Hal  tersebut  karena  informasi  wisata masih disampaikan secara tradisioanal dari mulut ke mulut, sehingga sebaran informasi kurang jauh dan relatif  sedikit. Untuk mengatasi masalah tersebut maka perlu adanya sebuah Sistem Informasi Pariwisata berbasis Web dengan metode waterfall di daerah Surabaya agar informasi bisa menyebar secara luas dan cepat. Sistem informasi ini menggunakan paradigma Model View Controller menggunakan Framework CodeIgneter dan DBMS Mysql. Sehingga hasil penelitian ini menunjukkan bahwa adanya sistem informasi pemesanan tiket wisata Kota Surabaya dijadikan sebagai solusi dalam memudahkan wisatawan melakukan pemesanan tiket wisata karena sudah tersedia di dalam sistem sehingga lebih tepat dan efisien. Serta menyarankan agar sistem informasi ini dapat dilakukan maintenance dan pembaruan data pada destinasi wisata yang disediakan oleh Kota Surabaya, seperti meminimalisir adanyanya kendala pemesanan tiket wisata untuk kuota yang tersedia maupun jam operasional desnitasi wisata tersebut.
NATURE EMULATING GLAZES IN CERAMICS: THE HISTORY OF CRATER GLAZES, DEVELOPING AND COLORING
Authors: Avinal Sinan
Published: May 2024

NATURE EMULATING GLAZES IN CERAMICS: THE HISTORY OF CRATER GLAZES, DEVELOPING AND COLORING

Abstract
Glazes applied to the surfaces of ceramic bodies sometimes provide functional benefits and sometimes make aesthetic contributions. Especially the colour and texture diversity of the glazes used in art ceramics makes ceramic forms aesthetically richer and more interesting. In this sense, artists who have mastered the technology of ceramics can produce glazes with their own recipes and use them as a personal language in their works of art. This possibility of creating an identity that the material gives to the artist has paved the way for the production of endless variations of glazes with organic and inorganic additives over time. Crater glazes, named after the term "crater" that emerges as a result of natural formations on the earth due to the similarity of its textural appearance, can be produced by adding silicon carbide (SiC), an inorganic substance, to the glaze. Silicon carbide, which creates a blistering effect, which is accepted as a defect in the glaze, shows that a defect can also make an aesthetic contribution with the crater image that appears when it is prescribed in appropriate proportions. In this article, the historical background of crater glazes is investigated, glossy and matte crater glazes are discussed and experimental applications are carried out with colouring alternatives.

Keywords: Ceramics, Glaze, Crater, Lava, Silicon Carbide.
Molecular dynamics study of interfacial thermal transport properties of graphene/GaN heterostructure
Authors: Liu Dong-Jing , Zhou Fu , Hu Zhi-Liang , Huang Jia-Qiang ,   Guangxi Key Laboratory of Manufacturing System & Advanced Manufacturing Technology, School of Mechanical and Electrical Engineering, Guilin University of Electronic Technology, Guilin 541004, China
Published: May 2024

The performance of interfacial thermal transport in heterostructure determines the reliability of micro- and nano-scale device. In this study, a molecular dynamics method is used to investigate the interfacial thermal transport properties of graphene/GaN sandwich heterostructure. The effects of temperature, defect, and size on the interface thermal conductance at the heterostructure are analyzed. It is found that the interface thermal conductance increases with temperature rising; at 1100 K, the interface thermal conductance of the 3-layer graphene heterostructure is increased by 61%. This increase is mainly attributed to the enhanced lattice vibrations at higher temperature, which excites more out-of-plane phonons. The presence of minor vacancy defects in GaN leads interface thermal conductance to increase, reaching a maximum value of 0.0357 GW/(m2·K) at a defect rate of 20%. This enhancement is believed to be due to additional thermal transport pathways created by the defects. However, as the defect rate increases further, the interface thermal conductance begins to decrease, which is thought to be due to interfacial coupling strength decreasing. With the number of GaN layers increasing from 8 to 24, the interface thermal conductance decreases, the change is attributed to the decrease of the number of phonons participating in the thermal transport across the interface. Conversely, with the number of graphene layers increasing from 2 to 6, the interface thermal conductance initially increases and then decreases. This behavior is related to initial improvements of phonon matching and coupling strength, followed by the increase in phonon scattering and localization. The results of this study provide a theoretical basis for regulating the interfacial thermal transport in microelectronic devices.
A Synergistic Workspace for Human Consciousness Revealed by Integrated Information Decomposition
Authors: Luppi Andrea I. , Mediano Pedro A.M. , Rosas Fernando E. , Allanson Judith , Pickard John D. , Carhart-Harris Robin L. , Williams Guy B. , Craig Michael M , Finoia Paola , Owen Adrian M. , Naci Lorina , Menon David K. , Bor Daniel , Stamatakis Emmanuel A.
Published: May 2024

A central goal of neuroscience is to understand how the brain orchestrates information from multiple input streams into a unified conscious experience. Here, we address two fundamental questions: how is the human information-processing architecture functionally organised, and how does its organisation support consciousness? We combine network science and a rigorous information-theoretic notion of synergy to delineate a “synergistic global workspace”, comprising gateway regions that gather synergistic information from specialised modules across the brain. This information is then integrated within the workspace and widely distributed via broadcaster regions. Through functional MRI analysis, we show that gateway regions of the synergistic workspace correspond to the brain’s default mode network, whereas broadcasters coincide with the executive control network. Demonstrating the empirical relevance of our proposed architecture for neural information processing, we show that loss of consciousness due to general anaesthesia or disorders of consciousness corresponds to a diminished ability of the synergistic workspace to integrate information, which is restored upon recovery. Thus, loss of consciousness coincides with a breakdown of information integration within the synergistic workspace of the human brain. This work contributes to conceptual and empirical reconciliation between two prominent scientific theories of consciousness, the Global Neuronal Workspace and Integrated Information Theory. Taken together, this work provides a new perspective on the role of prominent resting-state networks within the human information-processing architecture, while also advancing our understanding of how the human brain supports consciousness through the synergistic integration of information.
IQCH regulates spermatogenesis by interacting with CaM to promote the expression of RNA-binding proteins
Authors: Ruan Tiechao , Zhou Ruixi , Yang Yihong , Guo Junchen , Jiang Chuan , Wang Xiang , Shen Gan , Dai Siyu , Chen Suren , Shen Ying
Published: May 2024

IQ motif-containing proteins can be recognized by calmodulin (CaM) and are essential for many biological processes. However, the role of IQ motif-containing proteins in spermatogenesis is largely unknown. In this study, we identified a loss-of-function mutation in the novel gene IQ motif-containing H (
IQCH
) in a Chinese family with male infertility characterized by a cracked flagellar axoneme and abnormal mitochondrial structure. To verify the function of IQCH,
Iqch
-knockout mice were generated via CRISPR-Cas9 technology, which reproduced human phenotypes. Mechanistically, IQCH can bind to CaM and subsequently regulate the expression of RNA-binding proteins (especially HNRPAB), which are indispensable for spermatogenesis. Overall, this study revealed the function of IQCH, expanded the role of IQ motif-containing proteins in reproductive processes, and provided important guidance for genetic counseling and genetic diagnosis of male infertility.
Choline supplementation in early life improves and low levels of choline can impair outcomes in a mouse model of Alzheimer’s disease
Authors: Chartampila Elissavet , Elayouby Karim S. , Leary Paige , LaFrancois John J. , Alcantara-Gonzalez David , Jain Swati , Gerencer Kasey , Botterill Justin J. , Ginsberg Stephen D. , Scharfman Helen E.
Published: May 2024

Maternal choline supplementation (MCS) improves cognition in Alzheimer’s disease (AD) models. However, effects of MCS on neuronal hyperexcitability in AD are unknown. We investigated effects of MCS in a well-established mouse model of AD with hyperexcitability, the Tg2576 mouse. The most common type of hyperexcitability in Tg2576 mice, and many other mouse models and AD patients, are generalized EEG spikes (interictal spikes; IIS). Hyperexcitability is also reflected by elevated expression of the transcription factor ΔFosB in the granule cells (GCs) of the dentate gyrus (DG), which are the principal cell type. We also studied the hilus of the DG because hilar neurons regulate GC excitability. We found reduced expression of the neuronal marker NeuN within hilar neurons in Tg2576 mice, which other studies have shown is a sign of oxidative stress or other pathology.Tg2576 breeding pairs received a diet with a relatively low, intermediate or high concentration of choline. After weaning, all mice received the intermediate diet. In offspring of mice fed the high choline diet, IIS frequency declined, GC ΔFosB expression was reduced, and NeuN expression was restored. Spatial memory improved using the novel object location task. In contrast, offspring exposed to the relatively low choline diet had several adverse effects, such as increased mortality. They had the weakest hilar NeuN immunoreactivity and greatest GC ΔFosB. However, their IIS frequency was low, which was surprising. The results provide new evidence that a diet high in choline in early life can improve outcomes in a mouse model of AD, and relatively low choline can have mixed effects. This is the first study showing that dietary choline can regulate hyperexcitability, hilar neurons, ΔFosB and spatial memory in an animal model of AD.
FMNL2 regulates actin for endoplasmic reticulum and mitochondria distribution in oocyte meiosis
Authors: Pan Meng-Hao , Zhang Kun-Huan , Wu Si-Le , Pan Zhen-Nan , Sun Ming-Hong , Li Xiao-Han , Ju Jia-Qian , Luo Shi-Ming , Ou Xiang-Hong , Sun Shao-Chen
Published: May 2024

During mammalian oocyte meiosis, spindle migration and asymmetric cytokinesis are unique steps for the successful polar body extrusion. The asymmetry defects of oocytes will lead to the failure of fertilization and embryo implantation. In present study, we reported that an actin nucleating factor Formin-like 2 (FMNL2) played critical roles in the regulation of spindle migration and organelle distribution in mouse and porcine oocytes. Our results showed that FMNL2 mainly localized at the oocyte cortex and periphery of spindle. Depletion of FMNL2 led to the failure of polar body extrusion and large polar bodies in oocytes. Live-cell imaging revealed that the spindle failed to migrate to the oocyte cortex, which caused polar body formation defects, and this might be due to the decreased polymerization of cytoplasmic actin by FMNL2 depletion in the oocytes of both mice and pigs. Furthermore, mass spectrometry analysis indicated that FMNL2 was associated with mitochondria and endoplasmic reticulum (ER)-related proteins, and FMNL2 depletion disrupted the function and distribution of mitochondria and ER, showing with decreased mitochondrial membrane potential and the occurrence of ER stress. Microinjecting Fmnl2-EGFP mRNA into FMNL2-depleted oocytes significantly rescued these defects. Thus, our results indicate that FMNL2 is essential for the actin assembly, which further involves into meiotic spindle migration and ER/mitochondria functions in mammalian oocytes.
Hyperglycemia-induced cathepsin L maturation: Linking to diabetic comorbidities and COVID-19 mortality
Authors: He Qiong , Zhao Miao-Miao , Li Ming-Jia , Li Xiao-Ya , Jin Jian-Min , Feng Ying-Mei , Zhang Li , Huang Wei-Jin , Yang Fang-Yuan , Yang Jin-Kui
Published: May 2024

Diabetes, a prevalent chronic condition, significantly increases the risk of mortality from COVID-19, yet the underlying mechanisms remain elusive. Emerging evidence implicates Cathepsin L (CTSL) in diabetic complications, including nephropathy and retinopathy. Our previous research identified CTSL as a pivotal protease promoting SARS-CoV-2 infection. Here, we demonstrate elevated blood CTSL levels in individuals with diabetes, facilitating SARS-CoV-2 infection. Chronic hyperglycemia correlates positively with CTSL concentration and activity in diabetic patients, while acute hyperglycemia augments CTSL activity in healthy individuals.
In vitro
studies reveal high glucose, but not insulin, promotes SARS-CoV-2 infection in wild-type cells, with
CTSL
knockout cells displaying reduced susceptibility. Utilizing lung tissue samples from diabetic and non-diabetic patients, alongside db/db diabetic and control mice, we illustrate increased CTSL activity in both humans and mice under diabetic conditions. Mechanistically, high glucose levels promote CTSL maturation and translocation from the endoplasmic reticulum to the lysosome via the ER-Golgi-lysosome axis. Our findings underscore the pivotal role of hyperglycemia-induced CTSL maturation in diabetic comorbidities and complications.
An Hfq-dependent post-transcriptional mechanism fine tunes RecB expression in Escherichia coli
Authors: Kalita Irina , Iosub Ira Alexandra , McLaren Lorna , Goossens Louise , Granneman Sander , El Karoui Meriem
Published: May 2024

All living organisms have developed strategies to respond to chromosomal damage and preserve genome integrity. One such response is the repair of DNA double-strand breaks (DSBs), one of the most toxic forms of DNA lesions. In
Escherichia coli
, DSBs are repaired via RecBCD-dependent homologous recombination. RecBCD is essential for accurate chromosome maintenance, but its over-expression can lead to reduced DNA repair ability. This apparent paradox suggests that RecBCD copy numbers may need to be tightly controlled within an optimal range. Using single-molecule fluorescence mi-croscopy, we have established that RecB is present in very low abundance at mRNA and protein levels. RecB transcription shows high fluctuations, yet cell-to-cell protein variability remains remarkably low. Here, we show that the post-transcriptional regulator Hfq binds to
recB
mRNA and down-regulates RecB protein translation
in vivo
. Furthermore, specific disruption of the Hfq-binding site leads to more efficient translation of
recB
mRNAs. In addition, we observe a less effective reduction of RecB protein fluctuations in the absence of Hfq. This fine-tuning Hfq-mediated mechanism might have the underlying physiological function of maintaining RecB protein levels within an optimal range.
Lymphoid origin of intrinsically activated plasmacytoid dendritic cells in mice
Authors: Araujo Alessandra Machado , Dekker Joseph D , Garrison Kendra , Su Zhe , Rhee Catherine , Hu Zicheng , Lee Bum-Kyu , Osorio Daniel , Lee Jiwon , Iyer Vishwanath R , Ehrlich Lauren IR , Georgiou George , Ippolito Gregory , Yi Stephen , Tucker Haley O
Published: May 2024

We identified a novel mouse plasmacytoid dendritic cell (pDC) lineage derived from the common lymphoid progenitors (CLPs) that is dependent on expression of Bcl11a. These CLP-derived pDCs, which we refer to as ‘B-pDCs’, have a unique gene expression profile that includes hallmark B cell genes, normally not expressed in conventional pDCs. Despite expressing most classical pDC markers such as SIGLEC-H and PDCA1, B-pDCs lack IFN-α secretion, exhibiting a distinct inflammatory profile. Functionally, B-pDCs induce T cell proliferation more robustly than canonical pDCs following Toll-like receptor 9 (TLR9) engagement. B-pDCs, along with another homogeneous subpopulation of myeloid-derived pDCs, display elevated levels of the cell surface receptor tyrosine kinase AXL, mirroring human AXL+ transitional DCs in function and transcriptional profile. Murine B-pDCs therefore represent a phenotypically and functionally distinct CLP-derived DC lineage specialized in T cell activation and previously not described in mice.
Lymphoid origin of intrinsically activated plasmacytoid dendritic cells in mice
Authors: Araujo Alessandra M. , Dekker Joseph D. , Garrison Kendra , Su Zhe , Rhee Catherine , Hu Zicheng , Lee Bum-Kyu , Hurtado Daniel Osorio , Lee Jiwon , Iyer Vishwanath R. , Ehrlich Lauren I. R. , Georgiou George , Ippolito Gregory C. , Yi S. Stephen , Tucker Haley O.
Published: May 2024

We identified a novel mouse plasmacytoid dendritic cell (pDC) lineage derived from the common lymphoid progenitors (CLPs) that is dependent on expression of
Bcl11a
. These CLP-derived pDCs, which we refer to as “B-pDCs”, have a unique gene expression profile that includes hallmark B cell genes, normally not expressed in conventional pDCs. Despite expressing most classical pDC markers such as SIGLEC-H and PDCA1, B-pDCs lack IFN-α secretion, exhibiting a distinct inflammatory profile. Functionally, B-pDCs induce T cell proliferation more robustly than canonical pDCs following Toll-like receptor 9 (TLR9) engagement. B-pDCs, along with another homogeneous subpopulation of myeloid derived pDCs, display elevated levels of the cell-surface receptor tyrosine kinase AXL, mirroring human AXL
+
transitional DCs in function and transcriptional profile. Murine B-pDCs therefore represent a phenotypically and functionally distinct CLP-derived DC lineage specialized in T cell activation and previously not described in mice.
MOB rules: Antibiotic Exposure Reprograms Metabolism to Mobilize Bacillus subtilis in Competitive Interactions
Authors: Liu Yongjin , LaBonte Sandra , Brake Courtney , LaFayette Carol , Rosebrock Adam P. , Caudy Amy A. , Straight Paul D.
Published: May 2024

Antibiotics have dose-dependent effects on exposed bacteria. The medicinal use of antibiotics relies on their growth-inhibitory activities at sufficient concentrations. At subinhibitory concentrations, exposure effects vary widely among different antibiotics and bacteria.
Bacillus subtilis
responds to bacteriostatic translation inhibitors by mobilizing a population of cells (MOB-Mobilized
Bacillus
) to spread across a surface. How
B.
subtilis regulates the antibiotic-induced mobilization is not known. In this study, we used chloramphenicol to identify regulatory functions that
B. subtilis
requires to coordinate cell mobilization following subinhibitory exposure. We measured changes in gene expression and metabolism and mapped the results to a network of regulatory proteins that direct the mobile response. Our data reveal that several transcriptional regulators coordinately control the reprogramming of metabolism to support mobilization. The network regulates changes in glycolysis, nucleotide metabolism, and amino acid metabolism that are signature features of the mobilized population. Among the hundreds of genes with changing expression, we identified two,
pdhA
and
pucA
, where the magnitudes of their changes in expression, and in the abundance of associated metabolites, reveal hallmark metabolic features of the mobilized population. Using reporters of
pdhA
and
pucA
expression, we visualized the separation of major branches of metabolism in different regions of the mobilized population. Our results reveal a regulated response to chloramphenicol exposure that enables a population of bacteria in different metabolic states to mount a coordinated mobile response.
Evaluación de capacitación técnica entre ESTP y EMTP a través del Programa Ilumina
Authors:   , Bulnes Lueiza Gustavo Adolfo
Published: May 2024

La educación técnico profesional en Chile se compone de la educación media técnico profesional (EMTP) y la educación superior técnico profesional (ESTP), estrechamente vinculadas con la industria mediante marcos regulatorios que facilitan la inserción laboral y la continuidad de estudios. Este enfoque es especialmente relevante para brindar herramientas a alumnos vulnerables y su impacto es directo en la función educativaproductiva del país. La alineación de los perfiles de egreso con las necesidades de las empresas es fundamental, ya que la producción requiere capital humano preparado. Por tanto, la colaboración entre la educación TP y el mundo empresarial adquiere gran importancia. Una forma de fomentar esta colaboración es a través de prácticas de capacitación en módulos, herramientas, procesos u otros elementos impartidos por empresas privadas en los establecimientos técnico-profesionales. Los profesores TP deben adquirir conocimientos específicos provenientes del sector privado, útiles para los alumnos en su vida profesional, tránsito al trabajo y trayectoria formativa. En este contexto, el objetivo del proyecto es analizar una capacitación específica para sistematizar y resaltar buenas prácticas replicables en el ámbito técnico profesional. El caso es el Programa Ilumina, una alianza entre una empresa privada y una escuela de ingeniería de un instituto profesional. El programa logra una sistematización de las rutas formativas entre los subsistemas ESTP y EMTP en la zona sur de Santiago, enfocándose en habilidades de electrocontrol.
Eating Behaviour and Stress due to the Psychological Impact of COVID-19 among Bariatric Surgery Patients Resulting in Weight Regain: A Narrative Review
Authors: Monga Vidhi , Bhat Rayees Mohammad
Published: May 2024

The Coronavirus Disease-2019 (COVID-19) pandemic has significantly changed the lifestyle of people around the globe. Epidemics are well known for initiating mental stress and patients having undergone bariatric surgery for obesity are at high risk for the common presence of psychological co-morbidities The recent lockdowns imposed by various governments to curb the COVID-19 epidemic have affected the eating habits of many people. In patients with bariatric surgeries, eating disorders can have a profound impact on their health, leading to weight regain. Individuals who have undergone bariatric surgery may represent a particularly susceptible population. The adverse effects might be manifested in the form of eating disorders, psychological problems, and negative impacts on weight loss outcomes. There have been challenges in weight loss due to lockdowns, resulting in negative psychological impacts. Furthermore, changes in socialisation, routine physical activities, emotional stress, and experiences of trauma that have been evident at global levels might have a negative impact on the eating habits of bariatric surgery patients. The current paper highlights the psychological impact of COVID-19 among bariatric surgery patients resulting in weight regain caused by eating disorders and stress and addresses the psychological morbidity in this understudied population. In addition, the impact on the psychology of patients, as their surgeries have been delayed owing to lockdown procedures, has been discussed.
Green Manure for Sustainable Crop Production: A Review
Authors: Joshna Anambattu , Bokado Kangujam , Barkha .
Published: May 2024

Green manuring is an economical and eco-friendly scientific approach to achieve more resilient and sustainable food production for agricultural systems. Incorporation of green manure improves soil condition by increasing soil physical, chemical and biological properties such as organic matter, availability of nitrogen, phosphorus and potassium and also improves soil structure by preventing soil erosion, increasing water holding capacity etc. Green manure acts as a natural fertilizer, releasing nutrients into the soil as it decomposes and increases the nutrient content in the soil and shows positive effect on plant growth and development. Addition of green manure crops contribute to greater fixation of atmospheric nitrogen, and when decomposed, makes the nitrogen availability in the soil, reducing the need for synthetic nitrogen fertilizers in crops. Furthermore, it has a significant impact on several plant growth and yield parameters, resulting in increased agricultural productivity and ecosystem health.
Integrating Omics Approaches for Climate-Resilient Crops: A Comprehensive Review
Authors: Anusha M R  , Amir Mohammad
Published: May 2024

Climate change is a looming threat to global agriculture, impacting temperature, rainfall patterns, pest dynamics, and soil quality. These challenges transcend numerous crops vital for global food security. Drought, soil acidity, and nutrient fluctuations induced by climate change impede crop productivity, necessitating the development of breeding strategies to produce climate-resilient varieties. This review delves into the integration of omics approaches, including genomics, transcriptomics, proteomics, and metabolomics, to bolster breeding programs across diverse crops. By harnessing high-throughput technologies, researchers gain insights into the genetic and molecular mechanisms underlying traits such as stress resistance, yield, and disease tolerance. The cultivation of elite cultivars with enhanced stress tolerance is paramount for sustainable agriculture in the face of climate change. Various breeding approaches, encompassing functional genomics and mutagenomics, are explored alongside the application of genome editing tools like CRISPR/Cas9 and TALEN for targeted trait enhancement. Through the integration of multi-omics data, novel genetic targets are unearthed, facilitating the development of crop varieties resilient to climate-induced stressors beyond maize. This review underscores the significance of multi-omics in crop breeding and highlights strides made toward climate-resilient crop production. Understanding crop responses to abiotic stresses induced by climate change is imperative for the development of resilient varieties. The integration of modern genetics into classical breeding methods aims to cultivate stress-resistant cultivars, mitigating food security risks. Multi-omics approaches play pivotal roles in unraveling crop performance and stress tolerance mechanisms under diverse environmental conditions. Moving forward, the integration of multi-omics approaches will pinpoint candidate genes and pathways, enabling precision breeding to enhance crop performance amidst changing climates. These endeavors will propel the advancement of climate-resilient crops, safeguarding global food security in the face of climate change's challenges.
Impact of Digital Financial Inclusion on Rural Revitalization in Tanzania
Authors: George Njige Magreth , Ge Heping , Tang Decai
Published: May 2024

Technology has changed the financial industry through digitization, pushing financial services to be included. A sustainable rural economy has been developed due to the expansion of digital financial inclusion, which also significantly contributes to the revitalization of rural communities. This paper analyzes the theoretical connotations and mechanisms related to the study of the impact of digital inclusive of finance on rural revitalization in Tanzania; it empirically investigates the relationship between digital inclusive finance and rural revival by combining data at a national level in Tanzania. This study shows that digital inclusive finance can effectively promote the development of rural revitalization. By employing a time series model to measure the relationship between the digital inclusion of finance and rural revitalization. However, due  limitations such as data unavailability of most years due to the nature of the context being new in Tanzania and Africa as well; this paper highly recommends the development of rural digital infrastructure, enhancing the digitalization of inclusive finance with the aid of digital technologies, expanding the breadth and depth of digital inclusive finance services in rural areas, especially in economically underdeveloped regions, to promote the comprehensive and high-quality development of rural areas effectively.
ChemInform Abstract: Crystal Structure and Magnetism of YbMxGa4‐x, (M: Zn, Cd) with the BaAl4‐Type Structure.
Authors: GRIN YU. , HIEBL K. , ROGL P.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ca4Mg4Co3H19 and Yb4Mg4Co3H19, Containing Orientationally Disordered Square‐Pyramidal (CoH5)4‐ Anions.
Authors: HUANG B. , YVON K. , FISCHER P.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Preparation of Fine Nb3Al Powder by Hydriding and Dehydriding of Bulk Material.
Authors: LI X. G. , OHSAKI K. , MORITA Y. , UDA M.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Structure of Ba3In2O5F2 by Combined Powder X‐Ray and Neutron Diffraction Analysis; Oxide/Fluoride Ordering in a Ruddlesden‐Popper Phase.
Authors: NEEDS R. L. , WELLER M. T.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthetic Copper Monophosphate.
Authors: YAMASHITA A. , KAWAHARA A. , SASAKI N.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.