bluuebunny/crossref_metadata_2025 huggingface dataset:
Myelin basic protein and neurofilament H in postmortem cerebrospinal fluid as surrogate markers of fatal traumatic brain injury
Authors: Bohnert Simone , Wirth Christoph , Schmitz Werner , Trella Stefanie , Monoranu Camelia-Maria , Ondruschka Benjamin , Bohnert Michael
Published: April 2021

The aim of this study was to investigate if the biomarkers myelin basic protein (MBP) and neurofilament-H (NF-H) yielded informative value in forensic diagnostics when examining cadaveric cerebrospinal fluid (CSF) biochemically via an enzyme-linked immunosorbent assay (ELISA) and comparing the corresponding brain tissue in fatal traumatic brain injury (TBI) autopsy cases by immunocytochemistry versus immunohistochemistry. In 21 trauma and 19 control cases, CSF was collected semi-sterile after suboccipital puncture and brain specimens after preparation. The CSF MBP (p = 0.006) and NF-H (p = 0.0002) levels after TBI were significantly higher than those in cardiovascular controls. Immunohistochemical staining against MBP and against NF-H was performed on cortical and subcortical samples from also biochemically investigated cases (5 TBI cases/5 controls). Compared to the controls, the TBI cases showed a visually reduced staining reaction against MBP or repeatedly ruptured neurofilaments against NF-H. Immunocytochemical tests showed MBP-positive phagocytizing macrophages in CSF with a survival time of > 24 h. In addition, numerous TMEM119-positive microglia could be detected with different degrees of staining intensity in the CSF of trauma cases. As a result, we were able to document that elevated levels of MBP and NF-H in the CSF should be considered as usefulneuroinjurybiomarkers of traumatic brain injury.
Long-term outcomes of intravitreal activated protein C injection for ischemic central retinal vein occlusion: an extension trial
Authors: Hara Chikako , Kamei Motohiro , Sakaguchi Hirokazu , Matsumura Nagakazu , Sakimoto Susumu , Suzuki Mihoko , Nishida Kentaro , Fukushima Yoko , Nishida Kohji
Published: April 2021

Purpose

Our previous 1-year pilot study evaluated the efficacy of intravitreally injected activated protein C (APC) in 10 eyes with ischemic central retinal vein occlusion (CRVO). The reperfusion of the areas of retinal nonperfusion (RNP) exceeded 50% of the baseline in five (50%) eyes 1 year after the APC injection. The current study evaluated the long-term efficacy and safety of intravitreal APC.

Methods

The 10 eyes in the pilot study were included in this study. Other treatments were administered at the physicians’ discretion after the pilot study. We evaluated visual acuity (VA), central retinal thickness (CRT) and perfusion status, and adverse events and severity over the long term.

Results

The median follow-up was 60 months (range, 48–68 months). Compared with baseline, the post-treatment VA improved significantly (P < 0.001) from 1.39 to 1.06 logarithm of the minimum angle of resolution. The CRT improved significantly (P < 0.001) from 1090 to 195 μm at the last visit. The RNP areas decreased from an average 29.7 disc areas (DAs) at baseline to an average 16.5 DAs at the last examination (mean, 40 ± 6.5 months after the first APC treatment). No adverse events were related to intravitreal APC.

Conclusion

No complications were associated with intravitreal APC, the clinical course improved, and improved RNP was maintained for the long term, suggesting that intravitreal APC may be an alternative treatment for CRVO.
Hemispheric differences in altered reactivity of brain oscillations at rest after posterior lesions
Authors: Gallina Jessica , Pietrelli Mattia , Zanon Marco , Bertini Caterina
Published: April 2021

A variety of evidence supports the dominance of the right hemisphere in perceptual and visuo-spatial processing. Although growing evidence shows a strong link between alpha oscillations and the functionality of the visual system, asymmetries in alpha oscillatory patterns still need to be investigated. Converging findings indicate that the typical alpha desynchronization occurring in the transition from the eyes-closed to the eyes-open resting state might represent an index of reactivity of the visual system. Thus, investigating hemispheric asymmetries in EEG reactivity at the opening of the eyes in brain-lesioned patients may shed light on the contribution of specific cortical sites and each hemisphere in regulating the oscillatory patterns reflecting the functionality of the visual system. To this aim, EEG signal was recorded during eyes-closed and eyes-open resting state in hemianopic patients with posterior left or right lesions, patients without hemianopia with anterior lesions and healthy controls. Hemianopics with both left and right posterior lesions showed a reduced alpha reactivity at the opening of the eyes, suggesting that posterior cortices have a pivotal role in the functionality of alpha oscillations. However, right-lesioned hemianopics showed a greater dysfunction, demonstrated by a reactivity reduction more distributed over the scalp, compared to left-lesioned hemianopics. Moreover, they also revealed impaired reactivity in the theta range. This favors the hypothesis of a specialized role of the right hemisphere in orchestrating oscillatory patterns, both coordinating widespread alpha oscillatory activity and organizing focal processing in the theta range, to support visual processing at the opening of the eyes.
Multi-trophic communities re-establish with canopy cover and microclimate in a subtropical forest biodiversity experiment
Authors: Fornoff Felix , Staab Michael , Zhu Chao-Dong , Klein Alexandra-Maria
Published: April 2021

Plant diversity affects multi-trophic communities, but in young regrowth forests, where forest insects are in the process of re-establishment, other biotic and also abiotic factors might be more important. We studied cavity-nesting bees, wasps and their natural enemies along an experimental tree diversity gradient in subtropical South-East China. We compared insect communities of experimental young forests with communities of established natural forests nearby the experiment and tested for direct and indirect effects of tree diversity, tree basal area (a proxy of tree biomass), canopy cover and microclimate on bee and wasp community composition, abundance and species richness. Finally, we tested if the trophic levels of bees, herbivore-hunting wasps, spider-hunting wasps and their natural enemies respond similarly. Forest bee and wasp community composition re-established towards communities of the natural forest with increasing tree biomass and canopy cover. These factors directly and indirectly, via microclimatic conditions, increased the abundance of bees, wasps and their natural enemies. While bee and wasp species richness increased with abundance and both were not related to tree diversity, abundance increased directly with canopy cover, mediated by tree biomass. Abundance of natural enemies increased with host (bee and wasp) abundance irrespective of their trophic position. In conclusion, although maximizing tree diversity is an important goal of reforestation and forest conservation, rapid closure of canopies is also important for re-establishing communities of forest bees, wasps and their natural enemies.
Material parameter identification using finite elements with time-adaptive higher-order time integration and experimental full-field strain information
Authors: Hartmann Stefan , Gilbert Rose Rogin
Published: April 2021

In this article, we follow a thorough matrix presentation of material parameter identification using a least-square approach, where the model is given by non-linear finite elements, and the experimental data is provided by both force data as well as full-field strain measurement data based on digital image correlation. First, the rigorous concept of semi-discretization for the direct problem is chosen, where—in the first step—the spatial discretization yields a large system of differential-algebraic equation (DAE-system). This is solved using a time-adaptive, high-order, singly diagonally-implicit Runge–Kutta method. Second, to study the fully analytical versus fully numerical determination of the sensitivities, required in a gradient-based optimization scheme, the force determination using the Lagrange-multiplier method and the strain computation must be provided explicitly. The consideration of the strains is necessary to circumvent the influence of rigid body motions occurring in the experimental data. This is done by applying an external strain determination tool which is based on the nodal displacements of the finite element program. Third, we apply the concept of local identifiability on the entire parameter identification procedure and show its influence on the choice of the parameters of the rate-type constitutive model. As a test example, a finite strain viscoelasticity model and biaxial tensile tests applied to a rubber-like material are chosen.
Deformation of framed curves with boundary conditions
Authors: Hornung Peter
Published: April 2021

We provide a general approach to deform framed curves while preserving their clamped boundary conditions (this includes closed framed curves) as well as properties of their curvatures. We apply this to director theories, which involve a curve $$\gamma : (0, 1)\rightarrow \mathbb {R}^3$$

γ
:

(
0
,
1
)

→

R

3

and orthonormal directors $$d_1$$

d
1

, $$d_2$$

d
2

, $$d_3: (0,1)\rightarrow \mathbb {S}^2$$

d
3

:

(
0
,
1
)

→

S

2

with $$d_1 = \gamma '$$

d
1

=

γ
′

. We show that $$\gamma $$
γ
and the $$d_i$$

d
i

can be approximated smoothly while preserving clamped boundary conditions at both ends. The approximation process also preserves conditions of the form $$d_i\cdot d_j' = 0$$

d
i

·

d
j
′

=
0

. Moreover, it is continuous with respect to natural functionals on framed curves. In the context of $$\Gamma $$
Γ
-convergence, our approach allows to construct recovery sequences for director theories with prescribed clamped boundary conditions. We provide one simple application of this kind. Finally, we use similar ideas to derive Euler–Lagrange equations for functionals on framed curves satisfying clamped boundary conditions.
Millimeter-wave enabled PAM-4 data transmission over hybrid FSO-MMPOF link for access networks
Authors: Iqbal Saeed , Raza Aadil , Butt Muhammad Fasih Uddin , Mirza Jawad , Iqbal Muhammad , Ghafoor Salman , El-Hajjar Mohammed
Published: April 2021

In this paper, we propose a full duplex architecture based on a hybrid link composed of free space optics (FSO) and multimode plastic optical fiber (MMPOF) for short-range wireless access networks. The proposed architecture employs mode group division multiplexing (MGDM) and wavelength reuse techniques to transmit data between central unit (CU) and radio access units (RAUs). An optical frequency comb source to generate multiple optical sidebands is realized using a single laser source to provide 60 GHz millimeter-wave (mm-wave) signals at each RAU by simultaneously transmitting PAM-4 signal on linearly polarized (LP) modes of each optical sideband. Data rate of 2$$\times$$
×
12 Gbps at mm-wave frequency of 60 GHz is achieved for both downlink (DL) and uplink (UL) transmissions. The transmission of 2$$\times$$
×
12 Gbps PAM-4 signal over hybrid FSO-MMPOF link is investigated at different values of refractive index structure parameter ($$C_n^2$$

C
n
2

) by employing log-normal (LN) FSO channel model to support three RAUs in a ring topology. The acceptable receiver sensitivities below −5 and −0.6 dBm for DL and UL transmissions are achieved, respectively. The proposed hybrid architecture can be a potential candidate for future communication networks.
Unidirectional porous beta-tricalcium phosphate and hydroxyapatite artificial bone: a review of experimental evaluations and clinical applications
Authors: Funayama Toru , Noguchi Hiroshi , Kumagai Hiroshi , Sato Kosuke , Yoshioka Tomokazu , Yamazaki Masashi
Published: April 2021

In Japan, where allograft bone transplantation is not widespread, prospects for artificial bones are very high. Therefore, artificial bones with various compositions, porous structures, and porosities have been developed and employed for clinical use. Both Affinos® and Regenos® (made of beta-tricalcium phosphate and hydroxyapatite, respectively) are artificial bones with a unique unidirectional porous structure, in which pores with a diameter suitable for tissue penetration (25–300 μm) are aligned in one direction. The unidirectional porous structure allows rapid penetration of blood deep into the materials by a capillary effect. In animal experiments, Affinos® showed well-balanced resorption and was replaced with the host’s own bone from an early stage after implantation and new bone formation and remodeling were observed in the cortical bone and medullary cavity. When implanted for clinical situation, resorption from an early stage and good replacement with the patient’s own bone were also observed. Regenos® has an internal osteon-like material and a vascular-like structure that is maintained within the pores even after long-term implantation, as noted in an animal experiment. When implanted for clinical situation, good osteoconductivity was observed from an early stage of implantation. In addition, the material was observed to be slowly absorbed over time in some cases. We have discussed the beneficial effects of combining teriparatide and platelet-rich plasma impregnation and the potential prospects of these artificial bones.
Study on the correlation between the circle of Willis structure and collateral circulation in bilateral carotid artery occlusion
Authors: Liu Yang , Zhu Lei , Hou Bei , Wang Tuoyi , Xu Dechao , Tan Chenxi , Zhang Huiyi , Li Chunyan , Wang Jianan
Published: April 2021

Background and purpose

Bilateral carotid artery occlusion (CAO) is a rare condition and the collateral circulation is more complicated than in unilateral CAO. The circle of Willis (CoW) is the most important collateral circulation compensation pathway in CAO. However, the specific role of CoW in the collateral circulation compensation pathway of CAO has not been fully elucidated. The purpose of this study is to investigate the role of CoW in the collateral circulation compensation pathway of CAO.

Materials and methods

Clinical, imaging, and hemodynamic data of 30 patients with bilateral CAO were collected to analyze the collateral blood flow compensation pathway and its characteristics, and to examine the correlation between the structure of the CoW and the collateral circulation of bilateral CAO.

Results

This paper summarized 30 patients with bilateral CAO. There were 0 cases of the CoW complete type, 18 cases of the partially complete type (60%), and 12 cases of the incomplete type (40%). For the partially complete type cases, there were 14 complete anterior circulation cases (46.7%). The collateral circulation collateral circulation pathway included 14 cases with anterior communicating artery(ACoA), 7 cases with posterior cerebral artery (PCA)-middle cerebral artery (MCA) leptomeningeal anastomosis (LMA), 5 cases with ophthalmic artery(OA), 3 cases with lateral posterior communicating artery(PCoA), 1 case with internal carotid artery (ICA) stealing, 1 case with new Moyamoya vessels, and 4 cases of other types. There were four cases (13.3%) with complete posterior circulation, including four cases with bilateral PCoA, three cases with PCA-MCA LMA, and two cases with OA. There were 12 cases (40%) with incomplete CoW, including 8 cases with PCA-MCA LMA, 3 cases with lateral PCoA, 1 case with anterior cerebral artery (ACA)-MCA LMA, 4 cases with OA, and 1 other case.

Conclusion

The collateral circulation pathway differs among patients with different CoW structure types. When the CoW is partially complete, it mainly provides blood flow compensation to the ischemic area through primary collateral circulation. When the CoW is incomplete, it mainly provides blood flow compensation to the ischemic area through secondary collateral circulation.
Knowledge networks and strong tie creation: the role of relative network position
Authors: Tsouri Maria
Published: April 2021

The proximity literature usually treats proximity in terms of common attributes shared by agents, disregarding the relative position of an actor inside the network. This paper discusses the importance of such dimension of proximity, labelled as in-network proximity, and proposes an empirical measurement for it, assessing its impact (jointly with other dimensions of proximity) on the creation of strong knowledge network ties in ICT in the region of Trentino. The findings show that actors with higher in-network proximity are more attractive for both other central actors and peripheral ones, which is further strengthening their position within the network. In detail, the centrally positioned actors repeat collaboration with other central actors in the network, as central actors gather more ‘reputation’, signalling that they will possess the needed knowledge resources. Relatively peripheral actors, either new or not so active inside the network, seek for collaboration with relatively central actors in order to tap on knowledge resources they do not acquire.
A formalism for modelling traction forces and cell shape evolution during cell migration in various biomedical processes
Authors: Peng Q. , Vermolen F. J. , Weihs D.
Published: April 2021

The phenomenological model for cell shape deformation and cell migration Chen (BMM 17:1429–1450, 2018), Vermolen and Gefen (BMM 12:301–323, 2012), is extended with the incorporation of cell traction forces and the evolution of cell equilibrium shapes as a result of cell differentiation. Plastic deformations of the extracellular matrix are modelled using morphoelasticity theory. The resulting partial differential differential equations are solved by the use of the finite element method. The paper treats various biological scenarios that entail cell migration and cell shape evolution. The experimental observations in Mak et al. (LC 13:340–348, 2013), where transmigration of cancer cells through narrow apertures is studied, are reproduced using a Monte Carlo framework.
Landslide geometry and activity in Villa de la Independencia (Bolivia) revealed by InSAR and seismic noise measurements
Authors: Song Chuang , Yu Chen , Li Zhenhong , Pazzi Veronica , Del Soldato Matteo , Cruz Abel , Utili Stefano
Published: April 2021

Interferometric Synthetic Aperture Radar (InSAR) enables detailed investigation of surface landslide movements, but it cannot provide information about subsurface structures. In this work, InSAR measurements were integrated with seismic noise in situ measurements to analyse both the surface and subsurface characteristics of a complex slow-moving landslide exhibiting multiple failure surfaces. The landslide body involves a town of around 6000 inhabitants, Villa de la Independencia (Bolivia), where extensive damages to buildings have been observed. To investigate the spatial-temporal characteristics of the landslide motion, Sentinel-1 displacement time series from October 2014 to December 2019 were produced. A new geometric inversion method is proposed to determine the best-fit sliding direction and inclination of the landslide. Our results indicate that the landslide is featured by a compound movement where three different blocks slide. This is further evidenced by seismic noise measurements which identified that the different dynamic characteristics of the three sub-blocks were possibly due to the different properties of shallow and deep slip surfaces. Determination of the slip surface depths allows for estimating the overall landslide volume (9.18 · 107 m3). Furthermore, Sentinel-1 time series show that the landslide movements manifest substantial accelerations in early 2018 and 2019, coinciding with increased precipitations in the late rainy season which are identified as the most likely triggers of the observed accelerations. This study showcases  the potential of integrating InSAR and seismic noise techniques to understand the landslide mechanism from ground to subsurface.
The Hammer and the Nail: Biomechanics of Striking and Struck Canadian University Football Players
Authors: Brooks Jeffrey S. , Redgrift Adam , Champagne Allen A. , Dickey James P.
Published: April 2021

This study sought to evaluate head accelerations in both players involved in a football collision. Players on two opposing Canadian university teams were equipped with helmet mounted sensors during one game per season, for two consecutive seasons. A total of 276 collisions between 58 instrumented players were identified via video and cross-referenced with sensor timestamps. Player involvement (striking and struck), impact type (block or tackle), head impact location (front, back, left and right), and play type were recorded from video footage. While struck players did not experience significantly different linear or rotational accelerations between any play types, striking players had the highest linear and rotational head accelerations during kickoff plays (p ≤ .03). Striking players also experienced greater linear and rotational head accelerations than struck players during kickoff plays (p = .001). However, struck players experienced greater linear and rotational accelerations than striking players during kick return plays (p ≤ .008). Other studies have established that the more severe the head impact, the greater risk for injury to the brain. This paper’s results highlight that kickoff play rule changes, as implemented in American college football, would decrease head impact exposure of Canadian university football athletes and make the game safer.
Outcomes of Implementing in the Real World the Women's Health CoOp Intervention in Cape Town, South Africa
Authors: Wechsberg Wendee M. , Browne Felicia A. , Ndirangu Jacqueline , Bonner Courtney Peasant , Kline Tracy L. , Gichane Margaret , Zule William A.
Published: April 2021

Women in South Africa living with HIV who use alcohol may not adhere to ART, affecting the country’s 90-90-90 targets. The Women’s Health CoOp (WHC), a woman-focused HIV intervention, has shown efficacy in numerous trials with key populations of women in South Africa who use alcohol and drugs. In a hybrid implementation effectiveness study, the WHC was implemented in usual care clinics by healthcare providers in a modified stepped-wedge design. We present the outcomes of alcohol use and ART adherence with 480 women, with a 95% 6-month follow-up rate across 4 implementation cycles. Compared with the first cycle, women in the fourth cycle were significantly less likely (OR = 0.10 [95% CI 0.04, 0.24]) to report alcohol use disorder risk and were 4 times more likely (OR = 4.16 [95% CI 1.05, 16.51]) to report ART adherence at 6-month follow-up. Overall, acceptability and satisfaction were extremely high. The WHC intervention was successful in reaching key populations of women to reduce alcohol use and increase ART adherence, which is essential for South Africa to reach the 90-90-90 goals.
Efficiency and fairness criteria in the assignment of students to projects
Authors: Rezaeinia Nahid , Góez Julio César , Guajardo Mario
Published: April 2021

Teamwork has increasingly become more popular in educational environments. With the also increasing mobility trends in the educational sector, internationalization and other diversity features have gained importance in the structure of teams. In this paper, we discuss an assignment problem arising in the allocation of students to business projects in a master program in Norway. Among other problem features, the students state their preferences on the projects they most want to conduct. There are also requirements from the companies that propose the projects and from the program administration. We develop a bi-objective approach to consider efficiency and fairness criteria in this assignment problem. We test the model using real data of 2017 and 2018, in joint collaboration with the administrative staff of the program. In light of the good results, our proposed solutions have been implemented in practice in 2019 and 2020. The implementation of these solutions have been beneficial for the administration, the students, and the companies.
Factors associated with late risks of breast cancer-specific mortality in the SEER registry
Authors: Leone José P. , Vallejo Carlos T. , Hassett Michael J. , Leone Julieta , Graham Noah , Tayob Nabihah , Freedman Rachel A. , Tolaney Sara M. , Leone Bernardo A. , Winer Eric P. , Lin Nancy U.
Published: April 2021

Purpose

Most reports describing the risk of late relapse in breast cancer (BC) have been based on selected patients enrolled into clinical trials. We examined population-based long-term risks of BC-specific mortality (BCSM), the risks of BCSM conditional on having survived 5 years, and factors associated with late BCSM.

Methods

Using SEER, we identified women diagnosed with BC (T1-T2, N0-N2, M0) between 1990 and 2005 with known hormone receptor (HR) status. Kaplan–Meier analyses determined cumulative risks of BCSM. We performed Fine and Gray regression stratified by HR status.

Results

We included 202,080 patients (median follow-up of 14.17 years). Of all BC deaths, the proportion that occurred after 5 years was 65% for HR-positive vs 28% for HR-negative (p < 0.001) BC. In HR-positive BC, the cumulative risks of BCSM during years 5–20 were 9.9%, 21.9%, and 38% for N0, N1, and N2 disease. For HR-negative BC, the risks were 7.9%, 12.2%, and 19.9%, respectively. For T1a/b, N0, HR-positive BC, the risk of BCSM was 6 times lower than the risk of non-BCSM. In N2, HR-positive BC, the risk of BCSM was 43% higher than the risk of non-BCSM. In adjusted Fine and Gray models stratified by HR status, the risks of BCSM conditional on having survived 5 years for both HR-positive and HR-negative depended on T-N status, age, and year of diagnosis. In HR-positive, the risks also depended on race and grade.

Conclusion

The risks of BCSM beyond 5 years, although different, remain important for both HR-positive and HR-negative BC. Strategies to prevent early and late recurrences are warranted.
Modeling cesium migration through Opalinus clay: a benchmark for single- and multi-species sorption-diffusion models
Authors: Águila Jesús F. , Montoya Vanessa , Samper Javier , Montenegro Luis , Kosakowski Georg , Krejci Philipp , Pfingsten Wilfried
Published: April 2021

Sophisticated modeling of the migration of sorbing radionuclides in compacted claystones is needed for supporting the safety analysis of deep geological repositories for radioactive waste, which requires robust modeling tools/codes. Here, a benchmark related to a long term laboratory scale diffusion experiment of cesium, a moderately sorbing radionuclide, through Opalinus clay is presented. The benchmark was performed with the following codes: CORE2DV5, Flotran, COMSOL Multiphysics, OpenGeoSys-GEM, MCOTAC and PHREEQC v.3. The migration setup was solved with two different conceptual models, i) a single-species model by using a look-up table for a cesium sorption isotherm and ii) a multi-species diffusion model including a complex mechanistic cesium sorption model. The calculations were performed for three different cesium boundary concentrations (10−3, 10−5, 10−7 mol / L) to investigate the models/codes capabilities taking into account the nonlinear sorption behavior of cesium. Generally, good agreement for both single- and multi-species benchmark concepts could be achieved, however, some discrepancies have been identified, especially near the boundaries, where code specific spatial (and time) discretization had to be improved to achieve better agreement at the expense of longer computation times. In addition, the benchmark exercise yielded useful information on code performance, setup options, input and output data management, and post processing options. Finally, the comparison of single-species and multi-species model concepts showed that the single-species approach yielded generally earlier breakthrough, because this approach accounts neither for cation exchange of Cs+ with K+ and Na+, nor K+ and Na+ diffusion in the pore water.
Impact of COVID-19 on Early Childhood Educator’s Perspectives and Practices in Nutrition and Physical Activity: A Qualitative Study
Authors: Lafave Lynne , Webster Alexis D. , McConnell Ceilidh
Published: April 2021

Government guidelines for relaunching early childhood education and care (ECEC) programs during the COVID-19 pandemic have required the implementation of various practices to minimize the risk of infection transmission. These directives include recommendations regarding serving and handling food, shared spaces, and physical distancing which have a direct impact on the health and development of children in care. The purpose of this study was to explore early childhood educators’ perspectives on how COVID-19 guidelines have impacted the nutrition and physical activity practices within their ECEC environment. A qualitative description approach was used to explore a purposive sample of 17 educators working full time in ECEC centres during the pandemic between July and August 2020. Semi-structured, individual interviews were conducted, audio-recorded, transcribed verbatim, and analysed using a thematic analysis. Educators identified environmental changes in their environments noting a reduction in the quality food available for children juxtaposed with increased outdoor opportunities and a perceived increase in physical activity time. Teaching practices were also identified as being impacted by the COVID-19 guidelines. Curriculum, life skills, and social connectedness around healthy eating education was disrupted. Promoting physical activity education was challenged due to equipment, space, and curriculum enrichment opportunities losses. These findings demonstrate pronounced negative effects of COVID guidelines on nutrition and physical activity best practices within the ECEC environment. There is a need to support educators in maintaining healthy and active environments for preschoolers while following guidelines to minimize the risk of COVID infection transmission.
Multiple geochemical factors may cause iodine and selenium deficiency in Gilgit-Baltistan, Pakistan
Authors: Ahmad Saeed , Bailey Elizabeth H. , Arshad Muhammad , Ahmed Sher , Watts Michael J. , Young Scott D.
Published: April 2021

Deficiencies of the micronutrients iodine and selenium are particularly prevalent where populations consume local agricultural produce grown on soils with low iodine and selenium availability. This study focussed on such an area, Gilgit-Baltistan in Pakistan, through a geochemical survey of iodine and selenium fractionation and speciation in irrigation water and arable soil. Iodine and selenium concentrations in water ranged from 0.01–1.79 µg L−1 to 0.016–2.09 µg L−1, respectively, which are smaller than levels reported in similar mountainous areas in other parts of the world. Iodate and selenate were the dominant inorganic species in all water samples. Average concentrations of iodine and selenium in soil were 685 µg kg−1 and 209 µg kg−1, respectively, much lower than global averages of 2600 and 400 µg kg−1, respectively. The ‘reactive’ fractions (‘soluble’ and ‘adsorbed’) of iodine and selenium accounted for < 7% and < 5% of their total concentrations in soil. More than 90% of reactive iodine was organic; iodide was the main inorganic species. By contrast, 66.9 and 39.7% of ‘soluble’ and ‘adsorbed’ selenium, respectively, were present as organic species; inorganic selenium was mainly selenite. Very low distribution coefficients (kd = adsorbed/soluble; L kg−1) for iodine (1.07) and selenium (1.27) suggested minimal buffering of available iodine and selenium against leaching losses and plant uptake. These geochemical characteristics suggest low availability of iodine and selenium in Gilgit-Baltistan, which may be reflected in locally grown crops. However, further investigation is required to ascertain the status of iodine and selenium in the Gilgit-Baltistan food supply and population.
Pre-pandemic cognitive function and COVID-19 mortality: prospective cohort study
Authors: Batty George David , Deary Ian J. , Gale Catharine R.
Published: April 2021

Poorer performance on standard tests of pre-morbid cognitive function is related to an elevated risk of death from lower respiratory tract infections but the link with coronavirus (COVID‑19) mortality is untested. Participants in UK Biobank, aged 40 to 69 years at study induction (2006–10), were administered a reaction time test, an indicator of information processing speed, and also had their verbal-numeric reasoning assessed. Between April 1st and September 23rd 2020 there were 388 registry-confirmed deaths (138 women) ascribed to COVID-19 in 494,932 individuals (269,602 women) with a reaction time test result, and 125 such deaths (38 women) in the subgroup of 180,198 people (97,794 women) with data on verbal-numeric reasoning. In analyses adjusted for age, sex, and ethnicity, a one standard deviation slower reaction time was related to a higher rate of death from COVID-19 (hazard ratio; 95% confidence interval: 1.18; 1.09, 1.28), as was a one standard deviation disadvantage on the verbal-numeric reasoning test (1.32; 1.09, 1.59). While there was some attenuation in these relationships after adjustment for additional covariates which included socio-economic status and lifestyle factors, the two pre-pandemic indicators of cognitive function continued to be related to COVID-19 mortality.
Quantum Black Holes as Solvents
Authors: Aurell Erik , Eckstein Michał , Horodecki Paweł
Published: April 2021

Almost all of the entropy in the universe is in the form of Bekenstein–Hawking (BH) entropy of super-massive black holes. This entropy, if it satisfies Boltzmann’s equation $$S=\log \mathcal{N}$$

S
=
log
N

, hence represents almost all the accessible phase space of the Universe, somehow associated to objects which themselves fill out a very small fraction of ordinary three-dimensional space. Although time scales are very long, it is believed that black holes will eventually evaporate by emitting Hawking radiation, which is thermal when counted mode by mode. A pure quantum state collapsing to a black hole will hence eventually re-emerge as a state with strictly positive entropy, which constitutes the famous black hole information paradox. Expanding on a remark by Hawking we posit that BH entropy is a thermodynamic entropy, which must be distinguished from information-theoretic entropy. The paradox can then be explained by information return in Hawking radiation. The novel perspective advanced here is that if BH entropy counts the number of accessible physical states in a quantum black hole, then the paradox can be seen as an instance of the fundamental problem of statistical mechanics. We suggest a specific analogy to the increase of the entropy in a solvation process. We further show that the huge phase volume ($$\mathcal{N}$$
N
), which must be made available to the universe in a gravitational collapse, cannot originate from the entanglement between ordinary matter and/or radiation inside and outside the black hole. We argue that, instead, the quantum degrees of freedom of the gravitational field must get activated near the singularity, resulting in a final state of the ‘entangled entanglement’ form involving both matter and gravity.
Liming impacts barley yield over a wide concentration range of soil exchangeable cations
Authors: Holland J. E. , White P. J. , Thauvin J. -N. , Jordan-Meille L. , Haefele S. M. , Thomas C. L. , Goulding K. W. T. , McGrath S. P.
Published: April 2021

Liming has widespread and significant impacts on soil processes and crop responses. The aim of this study was to describe the relationships between exchangeable cation concentrations in soil and the relative yield of spring barley. The hypothesis was that yield is restricted by the concentration of a single exchangeable cation in the soil. For simplicity, we focused on spring barley which was grown in nine years of a long-term experiment at two sites (Rothamsted and Woburn). Four liming rates were applied and in each year the relative yield (RY) and the concentrations of exchangeable cations were assessed. Liming had highly significant effects on the concentrations of most exchangeable cations, except for Cu and K. There were significant negative relationships (either linear or exponential) between the exchangeable concentrations of Mn, Cd, Cr, Al, Fe, Cu, Co, Zn and Ni in soil and soil pH. The relationships between RY and the concentrations of selected exchangeable cations (Mn, Ca and Al) were described well using log-logistic relationships. For these cations a significant site effect was probably due to fundamental differences in soil properties. At both sites the concentrations of exchangeable soil Al were excessive (> 7.5 mg kg−1) and were most likely responsible for reduced barley yields (where RY ≤ 0.5) with soil acidification. At Rothamsted barley yield was non-limited (where RY ≥ 1) at soil exchangeable Mn concentrations (up to 417 mg kg−1) greater than previously considered toxic, which requires further evaluation of critical Mn concentrations.
Mitochondrial nicotinamide adenine dinucleotide hydride dehydrogenase (NADH) subunit 4 (MTND4) polymorphisms and their association with male infertility
Authors: Dahadhah Fatina W. , Jaweesh Mayyas Saleh , Al Zoubi Mazhar Salim , Alarjah Manal Issam Abu , Hammadeh Mohamad Eid , Amor Houda
Published: April 2021

Purpose

The purpose of the present study was to determine the relationship between infertility and the polymorphisms of mitochondrial NADH dehydrogenase subunit 4 (MTND4) by spermatozoa analysis in fertile and subfertile men.

Methods

Samples were divided into 68 subfertile men (case group) and 44 fertile men (control group). After semen analysis, samples were purified. The whole genome was extracted using a QIAamp DNA Mini Kit and the mitochondrial DNA was amplified by using the REPLI-g Mitochondrial DNA Kit. Polymerase chain reaction (PCR) was used to amplify the MT-ND4 gene. Then, samples were purified and sequenced using the Sanger method.

Results

Twenty-five single-nucleotide polymorphisms (SNPs) were identified in theMTND4gene. The genotype frequencies of the study population showed a statistically significant association between rs2853495 G>A (Gly320Gly) and male infertility (P= 0.0351). Similarly, the allele frequency test showed that rs2853495 G>A (Gly320Gly) and rs869096886 A>G (Leu164Leu) were significantly associated with male infertility (adjusted OR = 2.616, 95% CI = 1.374–4.983,P= 0.002; adjusted OR = 2.237, 95% CI = 1.245–4.017,P= 0.007, respectively).

Conclusion

In conclusion, our findings suggested that male infertility was correlated with rs2853495 and rs869096886 SNPs inMTND4.
Linear Stochastic Dyadic Model
Authors: Bianchi Luigi Amedeo , Morandin Francesco
Published: April 2021

We discuss a stochastic interacting particles’ system connected to dyadic models of turbulence, defining suitable classes of solutions and proving their existence and uniqueness. We investigate the regularity of a particular family of solutions, called moderate, and we conclude with existence and uniqueness of invariant measures associated with such moderate solutions.
Weak Convergence of Topological Measures
Authors: Butler Svetlana V.
Published: April 2021

Topological measures and deficient topological measures are defined on open and closed subsets of a topological space, generalize regular Borel measures, and correspond to (nonlinear in general) functionals that are linear on singly generated subalgebras or singly generated cones of functions. They lack subadditivity, and many standard techniques of measure theory and functional analysis do not apply to them. Nevertheless, we show that many classical results of probability theory hold for topological and deficient topological measures. In particular, we prove a version of Aleksandrov’s theorem for equivalent definitions of weak convergence of deficient topological measures. We also prove a version of Prokhorov’s theorem which relates the existence of a weakly convergent subsequence in any sequence in a family of topological measures to the characteristics of being a uniformly bounded in variation and uniformly tight family. We define Prokhorov and Kantorovich–Rubenstein metrics and show that convergence in either of them implies weak convergence of (deficient) topological measures on metric spaces. We also generalize many known results about various dense and nowhere dense subsets of deficient topological measures. The present paper constitutes a necessary step to further research in probability theory and its applications in the context of (deficient) topological measures and corresponding nonlinear functionals.
Systemic Problem Structuring in a Complex Hospital Environment using Viable System Diagnosis – Keeping the Blood Flowing
Authors: Vik Maren Berge , Finnestrand Hanne , Flood Robert L.
Published: April 2021

This article presents the application of the systemic problem structuring approach Viable System Diagnosis (VSD) within the Department of Orthopedic Surgery in a large hospital in Norway. It explains why systemic thinking is relevant to this uniquely complex form of human organization. The department was coping with systemic dysfunction and VSD was chosen because previous applications demonstrated VSD excels at diagnosis of what is causing dysfunction. VSD was employed through a participatory framework that included in the process, among other stakeholders, medics, technologists, managers, administrators and, as far as possible given the sensitive nature of patient information, the patient. VSD guided thinking about what the organization is set up to do and the existing organizational arrangements to achieve that. The outcome was an agenda for debate that guided stakeholder discussions toward ways and means of improving organizational arrangements. The article briefly reviews previous applications of VSD in the hospital sector and other large complex organisations.
Roles of factor Xa beyond coagulation
Authors: Ruf Wolfram
Published: April 2021

Oral anticoagulant therapy has changed by clinical evidence that coagulation factor Xa (FXa) can be safely and effectively targeted for thromboprophylaxis. Because thrombotic and thrombo-inflammatory diseases are frequently caused by excessive activation of the tissue factor (TF) pathway, activation of FX by the TF-FVIIa complex is of central importance for understanding the roles of FXa in thrombosis and hemostasis and functions beyond blood coagulation. Recent data showed that the nascent product FXa associated with TF-FVIIa not only supports hemostatic cofactor VIII activation, but also broadly influences immune reactions in inflammation, cancer, and autoimmunity. These signaling functions of FXa are mediated through protease activated receptor (PAR) cleavage and PAR2 activation occurs in extravascular environments specifically by macrophage synthesized FX. Cell autonomous FXa-PAR2 signaling is a mechanism for tumor-promoting macrophage polarization in the tumor microenvironment and tissue penetrance of oral FXa inhibitors favors the reprogramming of tumor-associated macrophages for non-coagulant therapeutic benefit. It is necessary to decipher the distinct functions of coagulation factors synthesized by the liver for circulation in blood versus those synthesized by extrahepatic immune cells for activity in tissue milieus. This research will lead to a better understanding of the broader roles of FXa as a central regulator of immune and hematopoietic systems.
Effects of Gas Trapping on Foam Mobility in a Model Fracture
Authors: Li Kai , Wolf Karl-Heinz A. A. , Rossen William R.
Published: April 2021

In enhanced oil recovery, foam can effectively mitigate conformance problems and maintain a stable displacement front, by trapping gas and reducing its relative permeability in situ. In this study, to understand gas trapping in fractures and how it affects foam behavior, we report foam experiments in a 1-m-long glass model fracture with a hydraulic aperture of 80 $$\upmu $$
μ
m. One wall of the fracture is rough, and the other is smooth. Between the two is a 2D porous medium representing the aperture in a fracture. The fracture model allows direct visualization of foam inside the fracture using a high-speed camera. This study is part of a continuing program to determine how foam behaves as a function of the geometry of the fracture pore space (AlQuaimi and Rossen in Energy & Fuels 33: 68-80, 2018a). We find that local equilibrium of foam (where the rate of bubble generation equals that of bubble destruction) has been achieved within the 1-m model fracture. Foam texture becomes finer, and less gas is trapped as interstitial velocity, and pressure gradient increase. Shear-thinning rheology of foam has also been observed. The fraction of trapped gas is significantly lower in our model (less than 7%) than in 3D geological pore networks. At the extreme, when velocity increases to 7 mm/s, there is no gas trapped inside the fracture. Our experimental results of trapped-gas fraction correlate well with the correlation of AlQuaimi and Rossen (SPE J 23: 788-802, 2018b) for fracture-like porous media. This suggests that the correlation can also be applied to gas trapping in fractures with other geometries.

Article Highlights

We have made a lab-scale 1-meter-long transparent glass model representing a geological fracture with roughened surface, and we have implemented a direct method of image analysis to quantify the texture of bubbles in the fracture and to link the texture with the strength of the foam;

We have successfully created surfactant-stabilized foam flow inside the fracture and examined its stability along the 1-meter-long fracture;

We explain the mechanism of gas trapping in fractures and how it affects foam behavior. We also discuss how viscous force and capillary force affect gas trapping in fractures at our experimental conditions.

Graphic Abstract
The characteristics and optimal treatment of urolithiasis associated with tuberous sclerosis complex
Authors: Hatano Takashi , Endo Katsuhisa
Published: April 2021

Purpose

The most common renal symptoms of tuberous sclerosis complex (TSC) are angiomyolipomas (AMLs) and renal cysts; however, some patients with TSC also develop urolithiasis. We retrospectively investigated the characteristics and treatment of urolithiasis associated with TSC.

Methods

We analyzed 142 patients who met the diagnostic criteria for TSC, of whom 20 (14.1%) had urolithiasis. We compared the patients’ characteristics, urinary specific gravity, urine pH, serum calcium and intact parathyroid hormone in the urolithiasis and non-urolithiasis groups. In the urolithiasis group, the stone characteristics and various treatments were analyzed.

Results

The antiepileptic drugs topiramate and zonisamide were more frequently administered to the urolithiasis group than the non-urolithiasis group (P = 0.013, P = 0.048, respectively). The urine specific gravity and urine pH levels were higher in the urolithiasis group than in the non-urolithiasis group (P = 0.005, P = 0.042, respectively). A multivariate logistic regression analysis demonstrated that urine-specific gravity (P = 0.018; odds ratio 1.471; 95% confidence interval 1.098–1.872) was a significant predictor of TSC-associated urolithiasis. Four patients could not receive extracorporeal shock wave lithotripsy due to the risk of bleeding from the AML.

Conclusion

Patients with TSC who have an increased urine specific gravity, alkaline urine, and a longer administration of topiramate and zonisamide tend to demonstrate an increased risk of developing urolithiasis and therefore such cases require adequate care. If urolithiasis is comorbid with TSC-associated AML, the treatment options are more limited in cases with multiple AMLs around the stone due to an increased risk of hemorrhage.