bluuebunny/crossref_metadata_2025 huggingface dataset:
Robust method for fringe demodulation under rapid phase and amplitude fluctuations
Authors: Vithin Allaparthi Venkata Satya , Gannavarpu Rajshekhar
Published: November 2021

In this article, an optimization framework using non convex, non smooth total generalized variation based regularization using surrogate principle is presented to mitigate the affects of fast varying phases and corruption of interferogram with noise and sudden amplitude changes.
ZnO Plasmonic Structure on a Tapered Optical Fiber
Authors: Kaur Navneet , Das Gautam
Published: November 2021

A plasmonic structure using ZnO on the surface of a tapered optical fiber was fabricated. The structure was manufactured using Optical tweezing. It can be used as a substrate for Surface-Enhanced Raman Spectroscopy (SERS).
Compressive Imaging Hyperspectral Polarimeter based on LCVR
Authors: Xu Zhilong , Ning Jianglan , Xie Yingge , Zhang Rui , Wu Dan , Wang Jian , Ren Wenyi
Published: November 2021

An LCVR-based compressed sensing hyperspectral polarization phenomenon technology is proposed. The results show that this method can further improve the system compression ratio and maintain superior performance.
Rot-Net: A Rotation Angle Detector between Multi-modal Images Using Siamese Network
Authors: Huang Yi-Hang , Li Ze-Yi , Zhang Haitao , Zhao Weiwei , Wang Yan
Published: November 2021

We construct an efficient learning framework to predict and correct the difference angle between multi-modal images without any additional auxiliary information. As a preprocessing of image registration, our network has good performance through multi-precision tests.
Improving the performance of Methane different absorption LiDAR system through up-conversion Technology
Authors: Shi Tianqi , Ma Xin , Han Ge , Gong Wei
Published: November 2021

Methane is an important kind of greenhouse warming gases that influence the global climate change. The detailed diffusion of methane still remains highly uncertainty, therefore, it’s meaningful to develop effectively method to detect atmosphere methane. Different absorption LiDAR (DIAL) has ability that to acquire the methane profile concentration with high accuracy. However, the wavelength of methane DIAL signal is usually around 1645 nm, the detection efficiency in infrared range is low in detectors. In this research, we present a solution to improve SNR of the received signal through up conversion technology, which would improve accuracy of the retrieved methane concentration.
Real-Time Data Processing for an Electro-Optic Dual-Comb Spectrometer
Authors: Nitzsche Leonard , Goldschmidt Jens , Kießling Jens , Wolf Sebastian , Kühnemann Frank , Wöllenstein Jürgen
Published: November 2021

To overcome the data burden of dual-comb spectrometers, we developed a data processing method for real-time spectra calculation during data acquisition. The spectra retain their envelope structure and the additional RMS-noise can be neglected.
Polarization Dehazing withDualImages Based on Dark Channel Quartering
Authors: Meng Yufei , Liu Chang , Wang Xiaoling , Zhou Zhehai
Published: November 2021

For the polarization dehazing, we proposed the dark channel quartering to estimate the atmospheric light intensity, and four vertical polarization images to obtain the dual images based on Stokes parameter.
Classification of Probe Quality in Ptychography
Authors: Lin Dergan , Jiang Yi , Deng Junjing , Di Zichao Wendy
Published: November 2021

The large volume of ptychographic dataset presents a challenge on computa- tional resources. We propose an unsupervised method that automatically identifies probes with diminished quality, and allows optimal distribution of resources on the most “informa- tive” dataset.
Image processing in polarimetric multi-view microscopy sensing
Authors: Llaguno Juan M. , Lecumberry Federico , Fernández Ariel
Published: November 2021

By means of a lenslet array and a polarization mask, image processing of elemental images allows us to obtain Stokes parameters in a single shot, as well as over video sequences of microscopic samples.
Cell Detection and Segmentation in Quantitative Digital Holographic Phase Contrast Images Utilizing a Mask Region-based Convolutional Neural Network
Authors: Kutscher Tobias , Eder Kai , Marzi Anne , Barroso Álvaro , Schnekenburger Jürgen , Kemper Björn
Published: November 2021

We analyzed the capabilities of a Mask Region-based Convolutional Neural Network to detect and segment macrophages in quantitative digital holographic phase images and demonstrate that both tasks can be performed in a single process.
Validation of a field-deployed detection system for angular light scattering measurements under natural conditions
Authors: Peckhaus Andreas , Hall Thomas , Bierbrauer Ute , Pargmann Carsten , Duschek Frank
Published: November 2021

High power laser radiation scattered outside of the beam axis can be a potential threat. A novel detection system based on angular light scattering can help to access the risk of scattering by atmospheric particles.
3D THz Tomography Incorporating the Beam Shape
Authors: Lumbeeck Lars-Paul , Paramonov Pavel , Sijbers Jan , De Beenhouwer Jan
Published: November 2021

A new reconstruction method incorporating the beam shape was developed for 3D Terahertz computed tomography using operators instead of matrices, solving data storing problems. We show that this method significantly improves the accuracy of recon- structions.
Performance of TES detectors for use in a far-infrared Fourier interferometer
Authors: Benson Chris S. , Spencer L. D. , Scott J.
Published: November 2021

Spatial-spectral double-Fourier interferometry has the potential for spatially resolved broadband spectroscopic observations in Far-infrared Astronomy. We present per- formance measurements of an array of 25 cryogenic transition-edge sensors for use in laboratory-based validation of the technique.
Overcoming Processing Challenges for a Post-dispersed Fourier Transform Spectrometer
Authors: Fulton Trevor , Naylor David , Huber Anthony , Gunuganti Sudhakar
Published: November 2021

We present some of the data processing challenges for a post-dispersed Fourier transform spectrometer and describe the techniques that were used to overcome them.
RSE-based Underwater Optical Camera Communication Impeded by Bubble Degradation
Authors: Zhou Zihao , Guan Weipeng , Wen Shangsheng , Xu Wenxi , Li Yue
Published: November 2021

Optical camera communication (OCC) is a promising technique. For the first time, we demonstrate a rolling-shutter-based OCC in the underwater bubble scenario with 36 kbit/s data rate by employing spatial-color multiplexing and de-bubble algorithm.
Broadband dual-comb spectroscopy for open-path field measurement of H216O and H218O
Authors: Herman Daniel I. , Giorgetta Fabrizio R. , Cossel Kevin C. , Malarich Nathan A. , Hutcherson Lindsay C. , Weerasekara Chinthaka , Cutshall Jacob M. , Newbury Nathan R. , Welch Stephen M. , DePaola Brett D. , Coddington Ian , Santos Eduardo A. , Washburn Brian R.
Published: November 2021

Simultaneous retrieval of H216O and H218 concentrations at an agricultural site is demonstrated using near-infrared open-path dual-comb spectroscopy (DCS). Initial retrievals of the isotopologue ratio δ18O have a statistical precision of 5‰ at one hour. Work of the US Government and not subject to copyright.
A frequency-shifting technique for pixel-wise absolute phase retrieval
Authors: Qi Zhaoshuai , Liu Xiaolin , Liu Xiaojun , Wang Wei , Yang Jiaqi , Zhang Yanning
Published: November 2021

A more general technique termed frequency-shifting (FS) is proposed, based on which the behavior of periodicity is eliminated and absolute phase can be retrieved pixel-wisely without any phase unwrapping.
Volume Holographic Multifocal Illumination Beam Shaper for Confocal Microscopy
Authors: Suresh Surag Athippillil , Vyas Sunil , Yeh J. Andrew , Luo Yuan
Published: November 2021

A volume holographic optical element is designed and fabricated using photopolymer (PQ- PMMA) for multifocal super Gaussian (SG) beam spots and can be used for illuminating sample in confocal microscopy to reduce the scanning time.
Ultrafast Transient Holographic Microscopy
Authors: Liebel Matz , Camargo Franco V. A. , Cerullo Giulio , van Hulst Niek F.
Published: November 2021

Ultrafast nanoscopy remains limited to small fields-of-view due to cameras’ slow acquisition speeds. We present a wide-field transient microscope in which off-axis holography enables shot-to-shot signal demodulation irrespective of the camera frame-rate.
Drug Resistance Classification of Cancer Cells Based on Digital Holographic Flow Cytometry and Machine Learning
Authors: Xin Lu , Xiao Wen , Che Leiping , Liu JinJin , Miccio Lisa , Bianco Vittorio , Memmolo Pasquale , Ferraro Pietro , Li Xiaoping , Pan Feng
Published: November 2021

In this work, we use digital holographic (DH) microscope coupled to a label-free and high-throughput microfluidic cytometer to automatically detect the drug resistance of Epithelial Ovarian Cancer (EOC) cells reinforced by machine learning.
Volumetric label-free histopathology using optical diffraction tomography
Authors: Hugonnet Herve , Lee Ariel J. , Kim Yeon Wook , Lee Moosung , Shin Seungwoo , Hruban Ralph H. , Hong Seung-Mo , Park YongKeun
Published: November 2021

We realized multiscale label-free volumetric histopathology of thick-tissue slides. The present method exploits label-free volumetric reconstruction of intrinsic refractive index distributions in tissues, and numerical algorithms for seamless stitching and reduction of scattering-induced image distortion.
Detection of Nitric Oxide at 5.26 µm using antiresonant hollow core fiber-assisted photothermal interferometry
Authors: Krzempek Karol , Kozioł Paweł , Jaworski Piotr , Dudzik Grzegorz , Hoppe Viktoria , Belardi Walter
Published: November 2021

Detection of Nitric Oxide at 5.26 µm is performed using photothermal interferometry and a 25 cm-long antiresonant hollow-core fiber as an absorption cell, reaching a minimum detection limit of 11 ppb for 144 seconds averaging.
Design Method of Holographic Mirror and Freeform Mirror for Automotive Augmented Reality Head-Up Display
Authors: Lee Songhyun , Bang Kiseung , Lee Byoungho
Published: November 2021

When a holographic mirror is applied to an automotive augmented reality head-up display, various aberrations including distortion occur. In this paper, we tried to solve this problem with two freeform mirrors.
Large Area Metalens for Compact Virtual Reality Optical Systems
Authors: Jang Junhyeok , Kim Kyuho , Kim Changhyun , Lee Byoungho
Published: November 2021

We experimentally demonstrate compact optical imaging systems for virtual reality with wide field of view by using the metalens with centimeter-scale diameter. We present a method of layout segmentation for fabricating the large area metalens.
Dynamical analysis of stress fields for a new thermo-photoelastic sample operate by magnetic induction
Authors: Restrepo-Martínez Alejandro , Álvarez Laura
Published: November 2021

Temporal photoelastic analysis variation of the stress field in epoxy-metal embedded samples affected by a magnetic induction heating was done. Some differences of the dynamics are associated to area analyzed and steel sheet size used.
Full-color Holographic System featuring Segmented Point Cloud Gridding and Parallel Computing for Real Objects
Authors: Zhao Yu , Zhu Li-Ming , Zhu Jin-Rong , Huang Yuan , Zhu Ming-Yu
Published: November 2021

We propose segmented point cloud gridding and parallel computing methods to accelerate the real object-based full-color holographic system. The feasibility of the proposed methods are confirmed by numerical and optical reconstruction.
Solid-State Laser Intra-Cavity Photothermal Sensor of Nitric Oxide in the mid-IR Region
Authors: Dudzik Grzegorz , Krzempek Karol , Jaworski Piotr , Kozioł Paweł
Published: November 2021

We present a novel, miniaturized configuration of a sub-ppm levels nitric oxide gas sensor. The gas sample concentration induces a photothermal effect inside a monolithic diode- pumped solid-state laser resonator in the Nd:YVO4/YVO4/Air-Gap structure.
Non-contact determination of orientation from the spectral response of metasurfaces
Authors: Akhmadiev T.M. , Efremova E.A. , Filatov Yu.V. , Shalymov E.V. , Venediktov V.Yu.
Published: November 2021

A new method for non-contact determination of object orientation is proposed. It consists in measuring the spectral position of resonant dips (or peaks) of metasurfaces’ response and their depth (height).
Density Functional Theory Calculated Raman Spectra of Ergocalciferol (Vitamin D2) and Cholecalciferol (D3)
Authors: Balcers Ojars , Miranda Ulises , Veilande Rita
Published: November 2021

Density functional theory (DFT)-calculated Infrared and Raman spectra of Vitamin D2 and D3 are presented. The calculated results are compared with each other and with available experimental data. Applicability of Raman spectra for non-invasive optical Vitamin D sensors is discussed.
Dense profiling of UTLS water vapour from low earth orbit using spatial heterodyne spectroscopy: Practical considerations, challenges and solutions
Authors: Langille Jeffery , Bourassa Adam , Degenstein Doug , Lloyd Nick , Solheim Brian , Paradis Simon , Lantange Stephane , Larouche Martin
Published: November 2021

The Spatial Heterodyne Observations of Water instrument (SHOW) is a limb imaging instrument that is being developed to provide accurate, dense, high vertical resolution measurements of water vapour in the upper troposphere and lower stratosphere. SHOW utilizes a field widened spatial heterodyne spectrometer operating in the limb viewing configuration to observe limb scattered sunlight in a small ~3 nm spectral window centered near 1365 nm. Vertically resolved images of the limb absorption spectrum are obtained with each frame that are inverted using non-linear optimal estimation to extract the vertical distribution of water vapour. The large throughput and high spectral resolution (0.02 nm unapodized) provided by the field widened SHS allows vertical profiles with a target vertical resolution of < 500 m to be obtained with rapid along track sampling (~50 km below 20 km and between 100 km – 300 km above 20 km) from a low earth orbit satellite. In this paper, we present the SHOW measurement concept and examine the practical considerations that influence design tradeoffs. We discuss the challenges and solutions that have been identified to optimize the instrument configuration and present an end-to-end simulation of the level 0 measurements, calibrations and level 2 water vapour product.
Comb-calibrated Spectroscopy in the 12–15 m Region
Authors: Lamperti M. , Gotti R. , Gatti D. , Shakfa M. K. , Cané E. , Tamassia F. , Schunemann P. , Laporta P. , Farooq A. , Marangoni M.
Published: November 2021

We present a comb-calibrated, widely tunable laser spectrometer in the bending mode region applied for metrology-grade measurements on the ν2 and ν11 bands of CO2 and benzene, respectively.
Compensation of Repetition Frequency Jittter in Fiber Frequency Comb Leveraging Long Short-Term Memory Neural Network
Authors: Ding Shangsu , Zhu En , Wu Chenglong , Shang Jianming , Yu Song
Published: November 2021

We demonstrated a digital repetition frequency locking system based on long short term memory(LSTM) model for fiber frequency comb. The standard deviation (SD) of locking state is 17mHz under 32MHz repetition frequency.
Photodetector nonlinearity in dual-comb interferometry
Authors: Guay Philippe , Hébert Nicolas Bourbeau , Tourigny-Plante Alex , Michaud-Belleau Vincent , Genest Jérôme
Published: November 2021

Nonlinearity of a commercial balanced photodetector is explained and corrected for dual-comb interferograms to yield high signal-to-noise ratio for short time measurements even in the case of a fully saturated detector.
Polarization-Sensitive Optical Coherence Tomography for detection of early-stage esophageal malignancy in mice
Authors: Chen Ping-Hsien , Chang Chung-Yu , Lai Hiu-Ki , Kuo Wen-Chuan
Published: November 2021

Detection of stromal change in-vivo is potential for
diagnosing esophageal cancer early. In 4-NQO mice model, flat
dysplasia and early cancer can be well identified on a birefringence
map based on Polarization-sensitive optical coherence tomography.
Evaluating Biomarker Features for Lung Cancer Using Machine Learning
Authors: Viswanathan P. , Prabhala S. , Lin J. , Roy H.K. , Subramanian H. , Backman V.
Published: November 2021

Machine learning is being applied to enhance the information garnered from biomarkers that are quantified from buccal samples for determining an individuals’ predisposition to lung cancer using partial wave spectroscopy.
Configuration dependent polarimetric second harmonic generation response of chiral collagen fibers in the microscope focal volume
Authors: Alizadeh Mehdi , Habach Fayez , Akens Margarete K. , Barzda Virginijus
Published: November 2021

Nonlinear response of chiral fibers depends on their configuration in the focal volume. The impact of fibers geometry on nonlinear optical parameters extracted using a polarimetric second harmonic generation (SHG) microscope has been studied.
High Resolution Multi-Modal and Multi-Scale Retinal Imaging for Clinical Settings
Authors: Shirazi M. F. , Andilla J. , Valdes C. P. , Lefaudeux N. , De Jesus D. Andrade , Brea L Sanchez , Klein S. , Van Walsum T. , Grieve K. , Paques M. , Torm M. , Larsen M. , Loza-Alvarez P. , Levecq X. , Chateau N. , Pircher M.
Published: November 2021

A compact multi-modal and multi-scale retinal imaging instrument is developed for clinical use. High resolution retinal images visualizing photoreceptors, choriocapillaris, and different vasculatures can be obtained by utilizing this instrument.
In vivo imaging of human cornea with Fourier-domain full-field optical coherence tomography equipped with a fast preview mode and a multimode fiber for spatial coherence reduction
Authors: Auksorius Egidijus , Borycki Dawid , Wojtkowski Maciej
Published: November 2021

We present an optimized Fourier-domain full-field optical coherence tomography system for corneal in vivo imaging that uses a line camera for real-time cross-sectional preview and a multimode fiber for preventing retinal damage.
An Automated Phoropter System for Objective, Accurate, and Rapid Assessment of the Visual Acuity
Authors: Ozgur Erol , Akhoundi Farhad , Draper Craig , Voorakanam Ram , O’Brien Nicholas , Wycoff Jaclyn , Blanche Pierre-Alexandre , Liang Chen , Peyman Gholam , Peyghambarian N.
Published: November 2021

We describe an automated phoropter employing fluidic lenses, measuring the visual acuity and correcting the vision without patient feedback within seconds. The <0.1 D measurement accuracy greatly surpasses the phoropters used in doctors’ offices.
Fluorescence Lifetime Imaging Distinguishes Glioblastoma Multiforme Infiltrative Edges in Patients
Authors: Anbunesan Silvia Noble , Alfonso-Garcia Alba , Weyers Brent W , Bec Julien , Frusciante Roberto P , Bobinski Matthew , Lee Han Sung , Bloch Orin , Marcu Laura
Published: November 2021

Fluorescence lifetime imaging was used during open craniotomy procedures to detect differences between healthy and tumor-infiltrated brain. Optical parameters validated against histopathological biomarkers demonstrate that brain regions with infiltrative glioblastoma multiforme are characterized by longer lifetime values relative to the adjacent healthy tissues.
Dual-color lensless fluorescence imaging by using a notch interference filter and absorption filters
Authors: Treepetchkul Thanaree , Kulmala Natcha , Sasagawa Kiyotaka , Takehara Hironari , Haruta Makito , Tashiro Hiroyuki , Ohta Jun
Published: November 2021

We demonstrate a dual-color lensless fluorescence imaging setup with a composite filter with a notch filter and absorption filters. By controlling the incident angle, high detection performance was achieved for green and red fluorescence.
Corrections of motion artifacts in dynamic low-cost, swept-source optical coherence tomography
Authors: Curatolo Andrea , Pachacz Angela , Solarski Jedrzej , Cetinkaya Onur , Consejo Alejandra , Marcos Susana , Wojtkowski Maciej , Karnowski Karol
Published: November 2021

OCT imaging of dynamic samples can give rise to significant misleading axial motion artifacts, depending on system specifications. Here, we investigate the axial shift phenomena in low-cost swept-source OCT dynamic measurements and simulations.
Phenotyping tumor-immune microenvironment (TiME) in vivo in patients using reflectance confocal microscopy
Authors: Sahu Aditi , Gill Melissa , Cordova Miguel , Santella Anthony , Kose Kivanc , Tembo Teguru , Alfonso Anabel , Chandrani Pratik , Wang Amber Weiching , Fox Christi , Gonzalez Salvador , Kurtansky Nicholas , Pulitzer Melissa , Phillips William , Li Madison , King Kimeil , Dusza Stephen , Liu Shuaitong , Yang Ning , Jilani Haaris , Mehta Paras , Marghoob Ashfaq , Halpern Allan , Rossi Anthony , Deng Liang , Chen Chih-Shan Jason , Rajadhyaksha Milind
Published: November 2021

In vivo phenotyping of tumor-immune microenvironment (TiME) for predicting response to immunotherapy in patients using non-invasive reflectance confocal microscopy (RCM) demonstrates high molecular and treatment response correlation.
Chromatin Reprogramming via Contact Guidance-Induced Nuclear Deformation Promotes Stem Cell Differentiation
Authors: Agrawal Vasundhara , Wang Xinlong , Li Yue , Virk Ranya K.A. , Patel Priyam A. , Jain Surbhi , Rivera-Bolanos Nancy , Frederick Jane , Roth Eric , Bleher Reiner , Duan Chongwen , Jiang Bin , Ntziachristos Panagiotis , Backman Vadim , Ameer Guillermo A.
Published: November 2021

Using chromatin packing macromolecular crowding (CPMC) model predictions and nanoscale imaging and sequencing studies, we demonstrate that micropillar structures enhance osteogenic differentiation by decreasing chromatin packing scaling in hMSCs and consequently increasing lineage-specific responsiveness.
Surface reconditioning of silver-based gratings for surface plasmon biosensors
Authors: Sarapukdee Pongsak , Pech Mathias , Schulz Dirk
Published: November 2021

Different surface restoration methods are analyzed to preserve optical properties in the silver grating deployed in biosensors when oxidation occurs as a surface degradation. The electrochemical treatment was the most approach to avoid degradation.
Direct Observation of Glucose Raman Fingerprint from in vivo Skin
Authors: Kang Jeon Woong , Galindo Luis H. , Dasari Ramachandra R. , So Peter T. C.
Published: November 2021

We demonstrate the direct observation of glucose Raman peaks from in vivo skin. The signal intensities varied proportional to the reference glucose levels and tracking spectral intensity based on the linearity enabled accurate prospective prediction.
Spatially resolved optical property measurements of microscale biological samples from 450nm to 1630nm
Authors: Mok Aaron T. , Shea Jamien , Tatarsky Rose , Bass Andrew , Yapici Nilay , Xu Chris
Published: November 2021

We present a simple and versatile approach to perform spatially resolved measurements of scattering and absorption properties of small biological samples (~ 1 mm in size) with high spatial resolution (~25µm) from 450nm to 1630nm.
Wireless wearable device for detection of transcutaneous tissue oxygenation based on phase phosphorimetry
Authors: Cascales Juan Pedro , Roussakis Emmanuel , Witthauer Lilian , Goss Avery , Li Xiaolei , Chen Yenyu , Marks Haley L , Evans Conor L
Published: November 2021

We have developed a wearable device to monitor tissue oxygenation transcutaneously through the detection of the phosphorescence lifetime of an oxygen sensing film. The device is wireless, weighs 30g and has been tested in vivo.
Microcirculation Diagnosis with Synchronous Electrocardiography Capturing and Contrast Enhancing Illumination
Authors: Kao Ying-Rue , Jhuang Bo-Cheng , Huang Yen-Chang , Kao Fu-Jen
Published: November 2021

In this study, microcirculation on body surface is observed synchronously with electrocardiography and blue LED illumination to enhance the video capturing of the flow of red blood cells and the subsequent extraction of cardiovascular signals accordingly.
Multiphoton-Excited Fabricated Collagen Scaffolds For Studying Cell Behavior in Pancreatic Cancer
Authors: Mancha Sophie , Campagnola Paul J. , Skala Melissa C.
Published: November 2021

Collagen promotion of cancer metastasis can be challenging to model. Multiphoton excited fabrication is used to construct scaffolds based on patient biopsies to study the role of collagen architecture on pancreatic cancer cell migration.
Artificial-intelligence Assisted, Label-free Imaging of Sub-cellular Biology
Authors: Burguete-Lopez Arturo , Makarenko Maksim , Getman Fedor , Fratalocchi Andrea
Published: November 2021

We discuss a technique enabling the recovery of refractive index and thickness maps of cells using bright-field microscopy and a suitably designed ultra-dark membrane. We show spatial resolutions as low as 50 nm, enabling organelle differentiation.
Forward-detection Fiber Scanning Endomicroscopy for Two-photon Fluorescence
Authors: Cui Haodong , Wang Conghao , Ma Jianrui , Liu Huilan , Wu Danlei , Wang Aimin , Feng Lishuang
Published: November 2021

We built a PZT drived forward-detection fiber scanning endomicroscopy for two-photon fluorescence. The overall structure and the formation of the driving signal were presented. Samples of pollen, large intestine and stomach were imaged.
Transcranial 1064-nm laser photobiomodulates human EEG brain networks at resting state identified by singular value decomposition and eLORETA
Authors: Wang Xinlong , Wanniarachchi Hashini , Liu Hanli
Published: November 2021

Right frontal delivery of transcranial photobiomodulation with 1064-nm laser enabled to increase the alpha oscillation power of nine resting-state brain networks as quantified by group singular value decomposition based on EEG signals from 37 healthy subjects.
Transcranial Photobiomodulation (tPBM) Enhances Local Hemodynamics and Global Dynamic Connectivity in the Cortex as Measured by fNIRS
Authors: Wanniarachchi Hashini , Wang Xinlong , Urquhart Elizabeth L. , Liu Hanli
Published: November 2021

1064-nm Transcranial Photobiomodulation (tPBM) on the right prefrontal cortex can increase the local hemodynamic oxygenation in the right prefrontal cortex and the dorsolateral prefrontal cortex. Also, tPBM can time-dependently improve the global brain connectivity.
Interactive Database for 2-Photon-Based Oxygen Phosphorescence Lifetime Imaging Data
Authors: Amra Layth , Mächler Philipp , Fomin-Thunemann Natalie , Desjardins Michèle , Kilic Kivilcim , Saisan Payam , Sencan Ikbal , Li Baoqiang , Sakadžić Sava , Devor Anna , Thunemann Martin
Published: November 2021

We present a graphical user interface-based database software for visualization, analysis, and export of experimental data of two-photon-based phosphorescence lifetime imaging of oxygen concentrations in the somatosensory cortex of awake mice.
Tapered Optical Fibers toward Depth Resolved Fluorescence Lifetime Photometry in brain tissue
Authors: Bianco Marco , Balena Antonio , Pisanello Marco , Pisano Filippo , Sileo Leonardo , Spagnolo Barbara , Montinaro Cinzia , Sabatini Bernardo L. , De Vittorio Massimo , Pisanello Ferruccio
Published: November 2021

We propose an optical method to perform fluorescence lifetime photometry with depth-resolution in brain tissue, exploiting far-field imaging of fluorescence signal collected by implantable tapered optical fibers.
Simulating Red and Near-Infrared Light Diffusion in Myometrium and Leiomyoma Uterus Tumors
Authors: Hamdy Omnia , Sheet Ahmed H.
Published: November 2021

Light diffusion in two types of uterus tumors based on their absorption and scattering parameters in red to near-infrared spectra was simulated using Monte-Carlo and finite-element methods to assist with conventional methods of tumor diagnosis.
Monitoring of vascular degeneration in a rat retina model by OCT angiography
Authors: Syu Jia-Pu , Chang Chen-Chieh , Kuo Wen-Chuan , Chiou Shih-Hwa
Published: November 2021

In this study, optical coherence tomography angiography (OCTA) was used to observe and quantify the progress of retinal degeneration in Royal College of Surgeons (RCS) rats. Vascular continually degenerates from 5-week-old RCS rats.
Classical Fundamental Limits in Phase Microscopy
Authors: Maestre Dante , Bouchet Dorian , Dong Jonathan , Juffmann Thomas
Published: November 2021

In our work, we show how the Cramér-Rao bound is calculated for any linear optical system and we demonstrate how this general framework can be applied for the design and optimization of classical phase microscopes.
Fully Organic, X-ray Radioluminescent Crystalline Colloidal Arrays for Next-Generation Bioimaging
Authors: Jones Haley W. , Bandera Yuriy , Foulger Stephen H.
Published: November 2021

An organic, x-ray radioluminescent colloid is fabricated by copolymerizing an organic scintillating monomer within a polystyrene basis. The intensity of emitted light from the radioluminescent colloidal particles can be manipulated by photonic means.
Organic X-Ray Radioluminescent Crystalline Colloidal Arrays Encapsulated in Poly(Ethylene Glycol) Methacrylate Based Hydrogel Films
Authors: Mell Sarah , Jones Haley W. , Bandera Yuriy , Foulger Stephen H.
Published: November 2021

Due to Coulombic forces, X-ray active copolymer nanoparticles self-assembled into crystalline colloidal arrays which were stabilized through encapsulation in hydrogels. The system was able to emit blue light when pumped with an X-ray source.
Convolutional Neural Network-based Optical Coherence Tomography (OCT) A-scan Segmentation and Tracking Platform using Advanced Monte Carlo Simulation
Authors: Guo Shoujing , Kang Jin U.
Published: November 2021

We reported a parallel Monte Carlo simulation platform for generating OCT cornea images and training the convolutional neural network. The trained network showed improved segmentation results when applied to the ex-vivo cornea A-scan images.
Label-free Quantification of Bilirubin Content using Absorption Spectrum
Authors: Mishra Swati , Wanare Harshawardhan
Published: November 2021

The wavelength range between 400-500 nm is universally studied to characterize bilirubin photoisomerization. We propose and demonstrate a label-free self-referenced measure that correlates the bilirubin quantity with specific band averaged absorption measurements.
Photodegradation study of Irgacure 2959 during hydrogel formation via 266 nm pulsed laser radiation
Authors: Tatiana Tozar , Mihai Boni , Simona Nistorescu , Lucian Pascu Mihai , Angela Staicu
Published: November 2021

Irgacure 2595 was exposed to 266 nm laser radiation to study its photodegradation rate in order to understand and improve hydrogel formation. The photodegradation process was monitored via fluorescence spectroscopy, UV-Vis and FTIR absorption spectroscopy. Comments and questions should be directed to the OSA Conference Papers staff (tel: +1 202.416.6191, e-mail: cstech@osa.org).
Development of a Method for Quantitative Fluorescence Analysis using a Correlation Detector
Authors: Bier Jonathan , Keusgen Michael , Frey Jochen
Published: November 2021

Development of an algorithm used in generic analyzation by implementing phase resolved evaluation using a correlation detector. As well as the reason for the use of two fluorophores as reference and marker.
Investigation of Changes of Optical Tissue Properties up to 50°C
Authors: Aumiller Maximilian , Eisel Maximilian , Heckl Christian , Freymüller Christian , Stepp Herbert , Sroka Ronald , Rühm Adrian
Published: November 2021

The temperature dependency (25°C – 50°C) of optical tissue properties was investigated on artificial and animal tissue samples. An increase of optical properties with temperature was found for all tissue phantoms and most tissue samples.
Monitoring the Optical Diffuse Transmittance of Skin during Thermo-Hydrotherapy via Spatial Frequency Domain Imaging: A Pilot Study
Authors: Abdelazeem Rania M. , Ahmed Mahmoud M. , Hamdy Omnia
Published: November 2021

In this work, the effect of the thermo-hydrotherapy procedure on the immerged skin has been evaluated optically by monitoring the skin diffuse transmittance based on spatial frequency domain imaging technique.
Brain virtual histology with X-ray phase-contrast tomography Part I: whole-brain myelin mapping in white-matter injury models
Authors: Chourrout Matthieu , Rositi Hugo , Ong Elodie , Hubert Violaine , Paccalet Alexandre , Foucault Louis , Autret Awen , Fayard Barbara , Olivier Cécile , Bolbos Radu , Peyrin Françoise , Crola-da-Silva Claire , Meyronet David , Raineteau Olivier , Elleaume Héléne , Brun Emmanuel , Chauveau Fabien , Wiart Marlene
Published: November 2021

White-matter injury leads to severe functional loss in many
neurological diseases. Myelin staining on histological samples is the
most common technique to investigate white-matter fibers. However,
tissue processing and sectioning may affect the reliability of 3D
volumetric assessments. The purpose of this study was to propose an
approach that enables myelin fibers to be mapped in the whole rodent
brain with microscopic resolution and without the need for strenuous
staining. With this aim, we coupled in-line (propagation-based) X-ray
phase-contrast tomography (XPCT) to ethanol-induced brain sample
dehydration. We here provide the proof-of-concept that this approach
enhances myelinated axons in rodent and human brain tissue. In
addition, we demonstrated that white-matter injuries could be detected
and quantified with this approach, using three animal models: ischemic
stroke, premature birth and multiple sclerosis. Furthermore, in
analogy to diffusion tensor imaging (DTI), we retrieved fiber
directions and DTI-like diffusion metrics from our XPCT data to
quantitatively characterize white-matter microstructure. Finally, we
showed that this non-destructive approach was compatible with
subsequent complementary brain sample analysis by conventional
histology. In-line XPCT might thus become a novel gold-standard for
investigating white-matter injury in the intact brain. This is Part I
of a series of two articles reporting the value of in-line XPCT for
virtual histology of the brain; Part II shows how in-line XPCT enables
the whole-brain 3D morphometric analysis of amyloid-

β

(A

β

) plaques.
fNIRS Artifact Removal Using Selective Source Separation
Authors: Dmitry Patashov , Yakir Menahem , Yoshinari Kameda , Dmitry Goldstein , Michal Balberg
Published: November 2021

Selective source separation is applied to fNIRS signals, followed by targeted filtering of artifacts only within relevant sources. Then, the filtered signal is reconstructed from the filtered sources with minimal distortion and high fidelity.
Robust feature extraction techniques for separating cerebral signals from the systemic changes in adult humans
Authors: Guerouah Zahida , Toronov Vladislav
Published: November 2021

We show effectiveness of two simple feature extraction techniques for separating specific cerebral autoregulation changes from the systemic ones measured by multi-distance hyperspectral near-infrared spectroscopy during breath holding.
Wide-Field Optical Imaging of Neurovascular Coupling during Stroke Recovery
Authors: Sunil Smrithi , Erdener Sefik Evren , Shah Shashwat , Jiang John , Boas David A.
Published: November 2021

Intrinsic and fluorescent calcium imaging was used to assess the evolution of hemodynamics and neural activity during stroke recovery. Recovery was assessed through cortical remapping of impaired limb, neurovascular coupling, and limb-use asymmetry.
Using Digital Pathology to Identify and Quantify Cerebral Microhemorrhages
Authors: Crouzet Christian , Chae Rachel H , Jeong Gwangjin , LoPresti Krystal T , Dunn Cody E , Xie Danny F , Agu Chiagoziem , Fang Chuo , Nunes Ane CF , Lau Wei Ling , Kim Sehwan , Cribbs David H , Fisher Mark , Choi Bernard
Published: November 2021

Studying cerebral microhemorrhages (CMHs) is a laborious and time-intensive process. To improve this process, we developed and compared three digital pathology approaches to identify and quantify CMHs from Prussian blue-stained brain sections.
Analysis of human iPSC-derived neuronal networks (hiPSCNN) using holographic single cell and full field optogenetic stimulation
Authors: Schmieder Felix , Habibey Rouhollah , Busskamp Volker , Büttner Lars , Czarske Jürgen W.
Published: November 2021

HiPSCNN Functional connectivity was investigated using optogenetics. Time-distance-correlations can be obtained using holographic single-neuron stimulation and provide deeper insights into of structure-function relations than full-field stimulation.
Multimodal Monitoring of Human Brain Organoids Implanted in Mice Using Transparent Microelectrodes
Authors: Thunemann Martin , Wilson Madison , Puppo Francesca , Pizzo Donald P. , Rickner Hannah , Bortz Emma , Mansour Abed AlFatah , Wolozin Benjamin , Han Xue , Gage Fred H. , Muotri Alysson R. , Kuzum Duygu , Devor Anna
Published: November 2021

We present an in vivo platform merging stem cell technology, two-photon imaging, and electrophysiology with transparent graphene microelectrodes for longitudinal interrogation of human brain organoids implanted in the cortex of immunodeficient mice.
A Mesoscopic Oblique Plane Microscopy (OPM) Platform for Centimeter Scale Volumetric Imaging
Authors: Shao Wenjun , Kilic Kivilcim , Yin Wenqing , Wirak Gregory , qin Xiaodan , Feng Hui , Boas David , Gabel Christopher V. , Yi Ji
Published: November 2021

We implemented a novel optical design to allow using low numerical aperture objective lens in OPM and achieved centimeter-scale volumetric imaging. It has great potential in large specimen imaging such as whole-brain imaging of mice.
Rapid imaging of deep-tissue motion with parallelized diffuse correlation spectroscopy
Authors: Xu Shiqi , Yang Xi , Konda Pavan Chanda , Horstmeyer Roarke
Published: November 2021

We present a highly parallelized approach to diffuse correlation spectroscopy (DCS) using a 32 × 32 single-photon avalanche diode (SPAD) array, which allows imaging dynamic scattering events buried deep within tissue phantom at a 2.5Hz frame rate without requiring any scanning or instrument movement.
Cerebral Blood Flow Monitoring via Superconductive Nanowire Single Photon Detection
Authors: Ozana Nisan , Mazumder Dibbyan , Zavriyev Alexander I. , Blackwell Megan , Carp Stefan A. , Franceschini Maria Angela
Published: November 2021

In this paper, we demonstrated a superconductive sensing-based system for cerebral blood flow monitoring via diffuse correlation spectroscopy at 1064nm. Findings show high brain sensitivity and fast monitoring using the presented system.
Scatterometry on whole brain sections using Scattered Light Imaging
Authors: Menzel Miriam , Ritzkowski Marouan , Grässel David , Schlömer Philipp , Amunts Katrin , Axer Markus
Published: November 2021

We present SLI Scatterometry: Scattered Light Imaging performed with individually controllable LEDs, allowing the measurement of full scattering patterns for each image pixel in a brain tissue sample, revealing complex nerve fiber architectures.
Targeted imaging system for voltage indicator readout
Authors: Whiteley Isabell , Song Chenchen , Knopfel Thomas , Rowlands Christopher J
Published: November 2021

A system for quasi-simultaneous direct recording from multiple neurons is presented. A digital micromirror device (DMD) is used to selectively illuminate specific neurons, switching between them at high speed to isolate voltage signals. © 2021 The Author(s)
Quantitative Cerebral Blood Flow Imaging with Synthetic Single-Shot Multi-Exposure Laser Speckle Imaging
Authors: Safi Abdul Mohaimen , Hernandez-Isidro Cesar , Cini Stephen , Moka Sadhu , Harrah Mitchell , Passaglia Christopher L. , Parthasarathy Ashwin B.
Published: November 2021

This paper demonstrates a novel approach for fast, single-shot Multi-Exposure Speckle Imaging of blood flow with a simplified imaging setup. Our method can transform existing single-exposure speckle images to quantitative flow images.
3D Fluid Flow Reconstruction Using A Compact Light Field Camera
Authors: Ding Yuqi , Li Zhong , Ji Yu , Yu Jingyi , Ye Jinwei
Published: November 2021

We present a flexible and low-cost 3D PIV solution that uses a compact light field camera as acquisition device. Real experiments demonstrate that our method can volumetric 3D fluid flows of various types.
An algorithmic method to identify multiple wood species in a single image by their specific fluorescence lifetimes
Authors: Leiter Nina , Wohlschläger Maximilian , Auer Veronika , Versen Martin , Laforsch Christian
Published: November 2021

Fluorescence lifetime imaging microscopy (FLIM) combined with an image processing algorithm is successfully used for the optical identification and areal separation of three wood species of maple, larch and nut in a single taken image.
Algorithm for the Helmholtz equation within bounded polygonal volumes
Authors: Zia Haider
Published: November 2021

We present a surface integral algorithm for optical fields within a volume enclosed by a convex polygonal surface. The algorithm, utilizing fast fourier-transforms, reduces the dimensional scaling, inherent as problem in FDTD and FEM methods.
Lens Aberration Calibration and Correction with Plasmonic Nanoparticles in Off-Axis Dark-Field Digital Holographic Microscope for Semiconductor Metrology
Authors: Messinis C. , van Schaijk T.T.M. , Pandey N. , Koolen A. , de Boer J.F. , Witte S. , den Boef A.J.
Published: November 2021

We present a method to calibrate and correct lens aberrations in dark-field Digital Holographic Microscope (df-DHM). In this method a gold nanoparticle is used to measure the point-spread function (PSF) of the df-DHM.
Approaching the Quantum Limit of sub-Diffraction Incoherent Barcode Reading
Authors: Grace Michael R. , Neifeld Mark A. , Ashok Amit , Guha Saikat
Published: November 2021

We developed a quantum-inspired adaptive algorithm using spatial-mode-demultiplexing measurements to read incoherently illuminated barcodes at large distances. In simulations, our scheme accurately discriminates barcodes in 20x less time than direct imaging at a standoff of 1 km.
Quantum-inspired Optical Super-resolution Adaptive Imaging
Authors: Lee Kwan Kit , Guha Saikat , Ashok Amit
Published: November 2021

We present an adaptive imaging scheme, inspired by quantum estimation theory, to estimate the number, brightness and locations of point sources in a constellation. Our simulation results demonstrate that the adaptive scheme outperforms traditional imaging.
Super-resolution from PSF width
Authors: Aarav Shaurya , Fleischer Jason W
Published: November 2021

We provide a simple technique to super-resolve two mutually incoherent point sources beyond the Rayleigh limit by measuring the width of the point spread function. We demonstrate the method experimentally at nearly 8 times the Rayleigh limit.
Differentiable Model-based Adaptive Optics for Microscopy
Authors: Vishniakou Ivan , Seelig Johannes D.
Published: November 2021

We demonstrate the usefulness of differentiable optimization approaches, as implemented in machine learning frameworks, for adaptive optics in microscopy. We show that aberrations can be corrected in an epidetection configuration only using reflected light. The method is also extended to two-photon scanning fluorescence microscopy.
A computational hyperspectral structured light sheet microscope
Authors: Crombez S , Leclerc P , Ray C , Ducros N
Published: November 2021

We describe here a hyperspectral light sheet microscope that is based on beam shaping and image reconstruction. Our approach has no moving parts and can be easily combined with a standard microscope.
Optimizing design of partially coherent illumination for refractive index tomographic microscopy
Authors: Li Jiaji , Zhou Ning , Bai Zhidong , Zhou Shun , Chen Qian , Zuo Chao
Published: November 2021

We propose the optimizing design of illumination pattern in partially coherent optical diffraction tomography (PC-ODT), and the custom-build quantitative criterion is demonstrated to maximize the performance of POTF related to the “goodness” evaluation of an illumination aperture. Source modulation with different segment scale and gray scale is implemented to acquire arbitrary distribution source, and the corresponding three-dimensional (3D) phase optical transfer function (POTF) can be easy obtained through the numerical incoherent superstition of each segment components. Further, the simulation and experimental results is presented support this finding as well, and the proposed method is expected to find versatile applications in biological and biomedical research.
A Multiple Degradation Maps Network For Spatial Compressed Sensing
Authors: Cui Can , Ke Jun
Published: November 2021

In this paper, we study a network MD-CSNet for spatial compressed sensing based on multiple degradation maps. The network can greatly improve the reconstruction speed while ensuring the quality of object reconstruction.
Ensemble Learning of Diffractive Optical Neural Networks
Authors: Rahman Md Sadman Sakib , Li Jingxi , Mengu Deniz , Rivenson Yair , Ozcan Aydogan
Published: November 2021

We report ensemble learning of diffractive optical neural networks that result in substantial improvements in the all-optical image classification accuracy of the resulting models.
Physics-Based Learned Design for Fourier DiffuserScope
Authors: Markley Eric , Liu Fanglin Linda , Kellman Michael , Antipa Nick , Waller Laura
Published: November 2021

We couple a differentiable forward model of diffuser-based single-shot 3D microscopy (Fourier DiffuserScope) with an invertible and differentiable reconstruction algorithm to jointly optimize the imaging system and the reconstruction parameters in a memory-efficient manner.
Active illumination compressive 4D spectral video imaging system
Authors: Ma Xiao , Yuan Xin , Fu Chen , Arce Gonzalo R.
Published: November 2021

A compressive 4D spectral video imaging system is proposed and verified in experiments. Active LEDs illumination scanning and DMD binary patterns are adopted with a new coding strategy to modulate a 4D scene in space, spectra, and time. Compressive sensing algorithm is applied to reconstruct 4D image-cube from a 2D grayscale compressive snapshot.
A faster convergence path of iterative phase reconstruction by using dynamic spectrum sampling method
Authors: Lin Xiao , Chen Ruixian , Hao Jianying , Zheng Qijing , Yu Changyu , Wang Suping , Qiu Xianying , Lin Dakui , Wang Kun , Yang Yi , Ren Yuhong , Tan Xiaodi
Published: November 2021

A dynamic spectrum sampling method is proposed to provide a faster convergence path of iterative phase reconstruction. The iterative number and the phase error rate are both reduced greatly in the experiment.
Fast simulations in Computer-Generated Holograms for binary data storage
Authors: Ballester Manuel , Schiffers Florian , Wang Zihao , Hasani Hamid , Fiske Lionel , Shedligeri Prasan , Tumblin Jack , Willomitzer Florian , Katsaggelos Aggelos K. , Cossairt Oliver
Published: November 2021

We present an efficient simulation of the recording and playback phases of a 2D image in a reflection volume hologram. The proposed algorithm uses the free-space Green’s function propagation and assumes the Born approximation.
SPAD 3D LiDAR sensors for automotive, industrial automation and surveillance
Authors: Villa Federica , Conca Enrico , Madonini Francesca , Zappa Franco
Published: November 2021

LiDAR systems based on SPAD single-photon detectors are a key technology for autonomous driving, industrial automation and military surveillance. Different architectures are analyzed and compared to pave the way towards next-generation LiDAR SPAD imagers.
Improved Flying-Spot Projector Design for Dense Dynamic Light-Transport Capture
Authors: Liu Xiaomeng , Henderson Kristofer , Rego Joshua , Jayasuriya Suren , Koppal Sanjeev
Published: November 2021

Dynamic light transport describes light rays interacting with moving objects. We present an improved flying-spot MEMS projector design with high SNR and resolution to capture dynamic scenes in both the line-of-sight and dual non-line-of-sight (NLoS).