bluuebunny/crossref_metadata_2025 huggingface dataset:
Genetic Variant HLA DRB1*0403 and Therapeutic Response to Diseases Modifying Therapies in Multiple Sclerosis: A Case‐Control Study
Authors: García-Ortega Yessica Eleanet , Goméz-Gaitan Esteban Alejandro , Macias-Islas Miguel Angel , Saldaña-Cruz Ana Miriam , Contreras-Haro Betsabe , Gamez-Nava Jorge Ivan , Perez-Guerrero Edsaul Emilio , Nava-Valdivia Cesar Arturo , Gallardo-Moya Sergio , Martínez-Hernández Alejandra , Gonzalez-Lopez Laura , Rios-González Blanca Estela , Marquez-Pedroza Jazmin , Méndez del Villar Miriam , Esparza-Guerrero Yussef , Vega-Villagomez Alejandra
Published: August 2023

Multiple sclerosis (MS) is a chronic and demyelinating disease with an autoimmune origin, in which inflammation and demyelination lead to neurodegeneration and progressive disability. The treatment target is slowing down the disease course and mitigating the symptoms. Approximately 30 to 50% of patients do not respond optimally to Disease Modifying Therapies (DMTs), in which therapeutic response may be influenced by genetic factors such as genetic variants. Therefore, our study aimed to investigate the association of HLA DRB1*0403 genetic variant and therapeutic response to DMTs in MS. We included 105 patients with MS diagnosis. No evidence of disease activity based on the absence of clinical relapse, disability progression or radiological activity (NEDA-3), was used to classify therapeutic response. Patients were classified as follows: a) control: patients who achieved NEDA-3 b) case: patients who did not achieve NEDA-3. DNA was extracted from peripheral blood leukocytes. HLA DRB1*0403 genetic variant was analyzed by quantitative polymerase chain reaction (qPCR) using TaqMan probes. NEDA-3 was achieved in 86.7% of MS patients treated with DMTs. Genotype frequencies were: GG 50.5%, GA 34.3% and AA 15.2%. No differences were observed in the genetic variant AA between patients who achieved NEDA-3 versus patients who did not achieve NEDA-3 (48.7% vs. 43.1%, p=0.6). We concluded that in Mexican patients with MS, HLA DRB1*0403 was not associated with therapeutic response to DMTs.
pH Quantification in Human Dermal Interstitial Fluid Using Ultra-Thin SOI Silicon Nanowire ISFETs and a High-Sensitivity Constant-Current Approach
Authors: Sprunger Yann , Capua Luca , Ernst Thomas , Barraud Sylvain , Locca Didier , Ionescu Adrian , Saeidi Ali
Published: August 2023

In this paper, we propose a novel approach to utilize silicon nanowires as high-sensitivity pH sensors. Our approach works based on fixing the current bias of silicon nanowires Ion Sensitive Field Effect Transistors (ISFETs) and monitor the resulting drain voltage as the sensing signal. By fine tuning the injected current levels, we can optimize the sensing conditions according to different sensor requirements. This method proves to be highly suitable for real-time and continuous measurements of biomarkers in human biofluids. To validate our approach, we conducted experiments, with real human sera samples to simulate the composition of human interstitial fluid (ISF), using both the conventional top-gate approach and the optimized constant current method . We successfully demonstrated pH sensing within the physiopathological range of 6.5 to 8, achieving an exceptional level of accuracy in this complex matrix. Specifically, we obtained a maximum error as low as 0.92\% (equivalent to 0.07 pH unit) using the constant-current method at the optimal current levels (1.71\% for top-gate). Moreover, by utilizing different pools of human sera with varying total protein content, we demonstrated that the protein content among patients does not impact the sensors' performance in pH sensing. Furthermore, we tested real-human ISF samples collected from volunteers. The obtained accuracy in this scenario was also outstanding, with an error as low as 0.015 pH unit using the constant-current method and 0.178 pH unit in traditional top-gate configuration.
AOGC: Anchor Free Oriented Object Detection Based on the Gaussian Centerness
Authors: Wang Zechen , Bao Chun , Cao Jie , Hao Qun
Published: August 2023

Oriented object detection is a challenging task in scene text detection and remote sensing image analysis, which has attracted extensive attention in recent years with the development of deep learning. Currently, mainstream oriented object detectors are based on preset anchor boxes. This method increases the computational load of the network and cause a large amount of anchor box redundancy. To solve this problem, we propose anchor-free oriented object detection based on the Gaussian centerness(AOGC), a single-stage anchor-free detection method. Our method uses contextual attention FPN(CAFPN) to obtain the contextual information of the target. Then we design a label assignment method for oriented objects. Finally, we develop a Gaussian kernel-based centerness branch, which can effectively determine the significance of different anchors. AOGC achieves mAP of 74.30% on the DOTA-1.0 datasets and 89.80% on the HRSC2016 datasets, respectively. AOGC exhibits superior performance to other methods in oriented anchor-free object detection methods.
A Comparative Study of Large Language Models in Explaining Intrinsically Disordered Proteins
Authors: Gonzalez David Taylor , Djulbegovic Mak , Kim Colin , Antonietti Michael , Gameiro Gustavo Rosa , Uversky Vladimir N.
Published: August 2023

(1) Background: Artificial Intelligence (AI) models have shown potential in various educational contexts. However, their utility in explaining complex biological phenomena, such as Intrinsically Disordered Proteins (IDPs), requires further exploration. This study empirically evaluated the performance of various Large Language Models (LLMs) in the educational domain of IDPs. (2) Methods: Four LLMs, GPT-3.5, GPT-4, GPT-4 with Browsing, and Google Bard (PaLM 2), were assessed using a set of IDP-related questions. An expert evaluated their responses across five categories: accuracy, relevance, depth of understanding, clarity, and overall quality. Descriptive statistics, ANOVA, and Tukey's honesty significant difference tests were utilized for analysis. (3) Results: The GPT-4 model consistently outperformed the others across all evaluation categories. Although GPT-4 and GPT-3.5 were not statistically significantly different in performance (p>0.05), GPT-4 was preferred as the best response in 13 out of 15 instances. The AI models with browsing capabilities, GPT-4 with Browsing and Google Bard (PaLM 2) displayed lower performance metrics across the board with statistically significant differences (p<0.0001). (4) Conclusion: Our findings underscore the potential of AI models, particularly LLMs such as GPT-4, in enhancing scientific education, especially in complex domains such as IDPs. Continued innovation and collaboration among AI developers, educators, and researchers are essential to fully harness the potential of AI for enriching scientific education.
Heterologous Interactions with Galectins and Chemokines and Their Functional Consequences
Authors: Mayo Kevin H. Henry
Published: August 2023

: Extra- and intra-cellular activity occurs under the direction of numerous inter-molecular interactions, and in any tissue or cell, molecules are densely packed, thus promoting those molecular interactions. Galectins and chemokines, the focus of this review, are small, protein effector molecules that mediate various cellular functions, in particular cell adhesion and migration, as well as cell signaling/activation. In the past, researchers have reported that combinations of these (and other) effector molecules act separately, yet sometimes in concert, but nevertheless physically apart and via their individual cell receptors. This view that each effector molecule functions independently of the other limits our thinking about functional versatility and cooperation, and, in turn, ignores the prospect of physiologically important inter-molecular interactions, especially when both molecules are present or co-expressed in the same cellular environment. This review is focused on such protein-protein interactions with chemokines and galectins, their homo- and hetero-oligomeric structures that they can form, and the functional consequences of those paired interactions.
Cyber Risk Contagion
Authors: Agosto Arianna , Giudici Paolo
Published: August 2023

Financial technologies, stemming from the application of artificial intelligence to big data in finance, are continuosly expanding, across different markets and financial services. While financial technologies bring many opportunities, such as reduced costs and extended inclusion, they also bring risks, among which cyber risks, which are constantly increasing and are difficult to measure.
Among the difficulties in measurememt lies the existence of interdependence among different cyber risks. The study of interdependence and possible contagion channels between cyber attacks to different institutions and economic sectors is indeed increasingly important to ensure economic and financial sustainability.
Against this backdrop, this paper proposers a multivariate model for count time series, in which the time-varying intensity parameter determining the probability that a cyber attack occurs evolves according to general autoregressive score models, taking both time and sectorial dependence into account.
The model is particularly suitable for studying how the behaviors of different markets or sectors are interconnected and it constitutes a new approach to the multivariate analysis of count time series of cyber loss events.
Peculiarities of the Spatial and Electronic Structure of 2-aryl-1,2,3-triazol-5-carboxylic Acids and Their Salts on the Basis of Spectral Studies and DFT Calculations
Authors: Alcolea Palafox Mauricio , Belskaya Nataliya P. , Kostova Irena P.
Published: August 2023

The molecular structure and vibrational spectra of six 1,2,3-triazoles-containing molecules with possible anticancer activity were investigated. In two of them, the optimized geometry was determined in the monomer, cyclic dimer and staking forms using the B3LYP, M06-2X and MP2 methods. The effect of the para-substitution in the aryl ring was evaluated based on the changes in the molecular structure and atomic charge distribution of the triazole ring. Several relationships were obtained that could facilitate the selection of the substituents on the triazole ring for their further synthesis. The observed IR and Raman bands in the solid state of two of these compounds were accurately assigned according to the functional calculations on the monomer and dimer forms, together with the polynomic scaling equation procedure (PSE).
Cariprazine in an Adolescent with Tourette Syndrome with Comorbid ADHD and Depression: A Case Report
Authors: Gill Jesjeet Singh
Published: August 2023

Tourette syndrome is a complex neuropsychiatric condition that manifests in childhood and is often associated with other psychiatric comorbidities. This case describes a young male with Tourette syndrome with major depressive disorder and attention deficit hyperactivity disorder (ADHD), who experienced troublesome side-effects due to his existing medications (escitalopram, risperidone and methylphenidate). In order to control his tics, ameliorate depressive symptoms, and eliminate side-effects of stiffness and sedation, risperidone was switched to cariprazine, a third-generation antipsychotic medication with D3-D2 partial agonism. In addition, the antidepressant dose was also increased. With the new combination, the patient reported good control of his tics, together with significant improvement in depressive symptoms and no side-effects. Based on this case and the reviewed literature, cariprazine might be a viable option for patients with Tourette syndrome with other comorbid illnesses, whom are prone to side effects of medication.
Consistency between Definition and Reasons for Applying Corporate Social Responsibility. The Perspective of Social Responsibility Managers
Authors: Licandro Oscar , Sánchez Luis Camilo Ortigueira , Huapaya-Huertas Oscar
Published: August 2023

Knowledge of the motivations of managers to practice Corporate Social Responsibility (CSR) is a critical issue for those who promote its adoption. The understanding of these reasons is complicated by the fact that there are different ways of defining this responsibility, raising the question of whether there is any relationship between reasons for adopting it and how to define it. To address this issue, a classification of these reasons was constructed and related to a classification of the different ways of defining CSR. A self-administered questionnaire was applied to a non-probability sample of Social Responsibility managers, which included indicators for both classifications. It was found that these managers present all types of motives, with proactive outweighing reactive motives and that there is a significant degree of correlation between the ways of defining CSR and the reasons for doing so. This suggests that managers present coherence in their objectives (motives) and means (practices of Social Responsibility.
PRAME Is a Multifaceted Cancer Testis Antigen with Diverse Roles as a Biomarker and Therapeutic Target
Authors: Bose Mukulika
Published: August 2023

Preferentially expressed Antigen in Melanoma (PRAME) is a cancer testis antigen (CTA) that is selectively expressed in certain somatic tissues, predominantly in the testis and is overexpressed in various cancers. PRAME family proteins are leucine rich repeat proteins, that are localized in the nucleus and cytoplasm, with multifaceted roles in immunity, during gametogenesis and in the overall reproduction process. It is a widely studied CTA and has been associated with the prognosis and therapeutic outcome in patients with epithelial and non-epithelial tumors. PRAME has also been studied extensively as a therapeutic target. Moreover, it has been found to play a role in most of the well-known cancer hallmarks. Interestingly, the role of PRAME in tumorigenesis is paradoxical. Over the last decade, PRAME has garnered substantial interest as a target for immunotherapy. There are multiple clinical trials and pre-clinical studies targeting PRAME alone or in combination with other tumor antigens. This review article is an attempt to update our knowledge and understanding of the context-dependent oncogenic functions of PRAME in various carcinomas, and the current immunotherapeutic strategies, challenges, and perspectives on developing newer strategies to target PRAME for a better outcome.
Advances in the Development of Representation Learning and Its Innovations against COVID-19
Authors: Li Peng , Mosharaf Md Parvej , Zhang Chenghao , Guo Shufang , Zhang Jing
Published: August 2023

In bioinformatics research, traditional machine learning methods have demonstrated efficacy in addressing Euclidean data. However, real-world data often encompasses non-Euclidean forms, such as graph data, which contain intricate structural patterns or high-order relationships that elude conventional machine-learning approaches. Representation learning seeks to derive valuable data representations from enhancing predictive or analytic tasks, capturing vital patterns and structures. This method has proven particularly beneficial in bioinformatics and biomedicine, as it effectively handles high-dimensional, sparse data, detects complex biological patterns, and optimizes predictive performance. In recent years, graph representation learning has become a popular research direction. It embeds graphs into a low-dimensional space while preserving the structural and attribute information of the graph, enabling better feature extraction for downstream tasks. This study extensively reviews representation learning advancements, particularly in the research of representation methods since the emergence of COVID-19. We begin with an analysis and classification of neural network-based language model representation learning techniques as well as graph representation learning methods. Subsequently, we explore their methodological innovations in the context of COVID-19, with a focus on the domains of drugs, public health, and healthcare. Furthermore, we discuss the challenges and opportunities associated with graph representation learning. This comprehensive review presents invaluable insights for researchers as it documents the development of COVID-19 and offers experiential lessons to preempt future infectious diseases. Moreover, this study guides future bioinformatics and biomedicine research methodologies.
Suitability of Coastal Reservoirs for Stormwater Harvesting in South Africa
Authors: Mokgele Reitumetse , Okedi And John
Published: August 2023

South Africa is a water stressed country experiencing mass urbanisation especially towards coastal cities. The country is already enduring the impacts of global warming and climate change with risk of water scarcity in many areas. The risk was evident with Cape Town near encounter with ‘Day Zero’ i.e., the day when water supplies would have been switched off and residents required to queue for daily water rations. The drought exposed the inadequa-cies of the existing water supply system. Paradoxically, in the same drought period, vast amounts of unutilized stormwater that could have augmented water supply run unabated into the ocean through rivers around the city. The study determined that the problem was not necessarily water shortage but lack of adequate water storage. This study investigated the suitability of coastal reservoirs for stormwater harvesting on the over 3000 km South African coastline. The objective was to identify suitable locations for coastal reservoirs. The study un-dertook a systematic process of selecting several candidate locations and eliminating unsuita-ble sites based on international best practice i.e., coastal topography, climate, hydrology, fluvi-al environment, catchment size and river water quality. Nine candidate sites were identified and ranked based on suitability and associated benefits. The identified locations in order of ranking include Knysna River, Berg River, Buffalo River, Kowie River, Thukela River, Orange River, Port of Richards Bay, Port of Durban, and Lourens River. The Knysna site, with a mean annual precipitation of 600 - 800 mm/annum and mean annual runoff of 100 - 500 Mm3/annum, was determined to be the most optimal location.
Transmission-Blocking Vaccines for Canine Visceral Leishmaniasis: New Progress and Yet New Challenges
Authors: Leite Jaqueline Costa , Gonçalves Ana Alice Maia , De Oliveira Diana Souza , Resende Lucilene Aparecida , Boas Diego Fernandes Vilas , Ribeiro Helen Silva , Pereira Diogo Fonseca Soares , Da Silva Augusto Ventura , Mariano Reysla Maria da Silveira , Reis Pedro Campos Carvalhaes , Nakasone Eiji Nakasone , França-Silva João Carlos , Galdino Alexsandro Sobreira , Paes Paulo Ricardo de Oliveira , Melo Marília Martins , Dias Edelberto Santos , Fumagalli Miguel Angel Chávez , Da Silveira-Lemos Denise , Dutra Walderez Ornelas , Giunchetti Rodolfo Cordeiro
Published: August 2023

The dogs with canine visceral leishmaniasis (CVL) play a key role in the transmission cycle of Leishmania infantum to humans in the urban environment. There is a consensus regarding the importance of developing a vaccine to control this disease. Despite many efforts to develop a protective vaccine against CVL, the ones currently available, CaniLeish®, Leish-tec® and LetiFend® have limited effectiveness. This is due, in part, to the complexity of the immune response of the naturally infected dogs against the parasite and the complexity of the parasite transmission cycle. Thus, strategies such as the development of a transmission-blocking vaccines (TBVs), already being applied to other vector-borne diseases like malaria and dengue, would be an attractive alternative to control leishmaniasis. TBVs induce the production of antibodies in the vertebrate host, which can inhibit parasite development in the vector and/or interfere with aspects of vector biology, leading to an interruption of parasite transmission. To date, there are few TBVs studies for CVL and other leishmaniasis forms. However, the few studies that exist show promising results justifying further development of this approach.
Circulating Sphingolipids in Obesity, Insulin Resistance, Diabetes and Associated Complications
Authors: Hammad Samar M. , Lopes-Virella Maria F
Published: August 2023

Sphingolipids play an important role in the development of diabetes both type 1 and type 2 diabetes as well as in the development of both micro- and macro-vascular complications. Several reviews have been published concerning the role of sphingolipids in diabetes but most of the emphasis has been on the possible mechanisms by which sphingolipids, mainly ceramides, contribute to the development of diabetes. Research on circulating levels of the different classes of sphingolipids in serum and in lipoproteins and their importance as biomarkers to predict not only the development of diabetes but also of its complications has only recently emerged and it is still in its infancy. This review summarizes the previously published literature concerning sphingolipid-mediated mechanisms involved in the development of diabetes and its complications focusing on how circulating plasma sphingolipid levels and the relative content carried by the different lipoproteins may impact their role as possible biomarkers both in the development of diabetes and mainly in the development of diabetic complications. Further studies in this field may open new therapeutic avenues to prevent or arrest/reduce both the development of diabetes and progression of its complications.
Effects of Adding Green Grape Juice to Cerasus humilis Juice on Chemical Composition and Antioxidant Properties
Authors: Wang Yuelei , Liu Yuqi , Ren Jing , Song Xing Shun
Published: August 2023

The objective of this investigation was to enhance the sensory appeal of Cerasus humilis (C. humilis) juice and ascertain potential interactions among bioactive compounds within a functional juice matrix. Sensory attributes, color, antioxidant potential, polyphenol and vitamin C (VC) concentrations, and sugar levels were assessed. Diverse dosage combinations were examined to determine their impact on the quality of both C. humilis and Green grape juices. Among the formulations, CG5 exhibited elevated antioxidant activit y and polyphenol content (455.02 mg TE/100 ml and 173.1 mg/100 ml, respectively), coupled with favorable consumer preference. Notable variations in compound content were observed across the seven analyzed juices. In the blended juices (CG1–CG5), interactions between distinct juices influenced VC and sugar levels, with other bioactives contributing to beneficial modifications, displaying a progressive rise. This study innovatively crafted delectable and convenient C. humilis juice, upholding its intrinsic high antioxidant activity, thereby presenting a novel avenue for marketable functional juice offerings.
Non-functional pancreatic neuroendocrine tumor (P-NET) presented by abdominal pain: case report and literature review
Authors: Regolo Matteo , Cardaci Nicolas , Salmeri Clara , Laudani Alfredo , Colaci Michele , Ippolito Massimo , Motta Fabio , Magrì Salvatore , Parisi Stefanie , Torcitto Alfredo Gaetano , Malatino Lorenzo
Published: August 2023

Pancreatic neuroendocrine tumor (P-NET) is a rare neoplasm originating in the neuroendocrine system. Carcinoid syndrome occurs in approximately 19% of patients with functional P-NETs, typically when liver metastases occur. NETs diagnosis is frequently late, along with symptoms related to hormone hypersecretion. We described the case of a patient with a low-grade non-functional P-NET, but with a typical clinical presentation of a carcinoid syndrome; moreover, we reviewed the literature regarding this topic. An 81-year-old male was admitted to our Department of Internal Medicine at Cannizzaro Hospital (Catania, Italy) because of the onset of abdominal pain with nausea, loose stools and episodic flushing. Firstly, an abdominal contrast-enhanced CT scan showed a small pancreatic hypervascular mass; then a gallium-68 DOTATOC integrated PET/CT revealed an elevated expression of SSTR receptors. Serum Chromogranin A and urinary 5-HIAA measurements resulted negative. Given the small size of the lesion (8 mm), we preferred to perform an endoscopic ultrasonography (EUS) with fine-needle biopsy (EUS-FNB), allowing the diagnosis of low-grade (G1) non-functional P-NET (NF-P-NET). Surgery was waived, while a follow-up strategy was chosen. Early recognition of P-NETs, although rare, is necessary to improve patient’s survival. EUS-FNB should be the protocol of choice for an early characterization of these tumors.
Tudo é novo? uma análise das significações de “inovação curricular” no Novo Ensino Médio
Authors: Silva Diego Miranda da , Albino Ângela Cristina Alves , Honorato Rafael Ferreira de Souza
Published: August 2023

O objetivo do artigo é analisar as concepções de inovação educacional presentes na Base Nacional Comum Curricular do Ensino Médio (BNCC) e nas propagandas publicitárias do Novo Ensino Médio. De cunho qualitativo, documental e bibliográfico, o estudo analisou as propagandas do Novo Ensino Médio veiculadas na TV, rádio, redes sociais, além do documento oficial da BNCC e da Lei 13415/2017. Com base nos dados, adotamos a abordagem da Análise Crítica do Discurso, desenvolvida por Fairclough, na qual considera a prática discursiva como uma forma de confronto por hegemonia, capaz de reproduzir, reorganizar ou contestar as normas discursivas estabelecidas. Nas propagandas, o Novo Ensino Médio é apresentado como uma inovação, mas a BNCC é, intertextual e interdiscursiva baseada em filosofias educacionais neoliberais das décadas de 70 e 90, dando prioridade a uma educação centrada nos princípios do mundo do trabalho e negligenciando outras áreas do conhecimento.
Scleroatrophic lichen: etiology, clinical presentation, and treatment
Authors:   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation, Dobrokhotova Yu.E. , Borovkova E.I. ,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation, Burdenko M.V. ,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation, Azimova A.Yu. ,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation, Davydova D.S. ,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation, Prilutskaia S.V. ,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation, Blinnikova D.A. ,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation
Published: August 2023

Scleroatrophic lichen (lichen sclerosus) is a benign progressive disease characterized by marked skin inflammation, epithelial thinning, and itching. The etiology of scleroatrophic lichen is unknown. Autoimmune, hormonal, inflammatory, and genetic factors are indicated in the pathogenesis of the disease. Dominant clinical manifestations include marked itching, tissue thinning, dyspareunia, and dysuria. Chronic inflammation gradually leads to irreversible changes in tissue architectonics. Topical glucocorticosteroids for 4–6 weeks are the first-line treatment for scleroatrophic lichen. To improve tissue trophism, the combined use of topical agents with hyaluronic acid and lanolin is effective. Key words: scleroatrophic lichen, lichen, vulvodynia, topical glucocorticosteroids, dyspareunia, hyaluronic acid, lanolin, superlymph
Use of progestogens during pregnancy and incidence of severe pre-eclampsia: a comparative analysis
Authors:   V.F.Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russian Federation, V.B.Tskhay V.B.Tskhay ,   Federal Siberian Research and Clinical Center, Krasnoyarsk, Russian Federation, V.N.Konovalov V.N.Konovalov ,   V.F.Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russian Federation, N.S.Lysenko N.S.Lysenko ,   V.F.Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russian Federation, A.M.Iptyshev A.M.Iptyshev ,   V.F.Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russian Federation
Published: August 2023

Objective. To study the effect of progestogen administration during pregnancy, particularly of dydrogesterone, on the incidence of severe pre-eclampsia (PE) and its efficacy in preventing PE depending on dosage. Patients and methods. A retrospective comparative study included three groups of pregnant women at risk for severe PE who received dydrogesterone as indicated at a dose of 30 mg (n = 19), 20 mg (n = 24) from 6 to 20 weeks’ gestation, and who did not receive progestogens (n = 98). Results. It was found that the group of pregnant women at risk for severe PE who received dydrogesterone at a dose of 30 mg/day from 6 to 20 weeks’ gestation developed an early-onset PE (before 34 weeks), which is the most adverse form of PE, significantly less frequently and had fewer cases of fetal growth restriction (FGR) and placental insufficiency (sub- and decompensated) compared to similar complications in the comparison group (without dydrogesterone). In the group of pregnant women at risk for severe PE who received dydrogesterone at a dose of 20 mg/day from early pregnancy, there were no statistically significant differences in the onset of PE, the incidence of preterm birth, FGR, and severe placental insufficiency compared to similar complications in the comparison group. Conclusion. The use of dydrogesterone at a dose of 30 mg from early pregnancy until 20 weeks is pathogenetically grounded and effective for preventing PE, reducing the incidence of early-onset PE and, accordingly, preventing adverse obstetric and perinatal outcomes. Key words: pregnancy, pre-eclampsia, prevention, gestagens, dydrogesterone
Association of genetic polymorphisms of folate cycle enzymes with risk of pregnancy complications
Authors:   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Putintseva A.V. , Shikh E.V. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Published: August 2023

Polymorphisms in the genes of folate cycle enzymes are considered as the main cause of reduced plasma levels of folate and vitamin B12, impaired homocysteine metabolism, and the development of pregnancy complications. Objective. To study the association of polymorphism in folate cycle enzyme genes, MTHFR-677C>T, MTHFR-1298A>C, MTR‑2756A>G, MTRR-66A>G, with the risk of pregnancy complications. Patients and methods. The study was conducted in outpatient settings and included 96 women aged between 20 and 40 years with a history of 1 to 3 pregnancies who applied for preconception care. Results. When examining the association between the presence of a complicated history in this group of women and folate cycle enzyme gene polymorphisms using the Fisher test, a statistically significant correlation was detected for MTHFR-677C>T, MTHFR-1298A>C, MTR-2756A>G, and MTRR-66A>G. Conclusion. The presence/absence of genetic polymorphisms of folate cycle enzymes should be considered when predicting the risks of pregnancy complications and developing a personalized preconception care program to select individual regimens of folate supplementation. Key words: genes, folate cycle, polymorphism, folates, pregnancy
Impact of low-dose dexamethasone on pregnancy outcome in type A PCOS women candidate for IVF/ICSI using the gonadotropinreleasing hormone antagonist protocol
Authors:   Ain Shams University, Egypt, Abdelrahim A.M. , Sammor H.M. ,   Ain Shams University, Egypt, Gomaa M.F. ,   Ain Shams University, Egypt, Mahmoud A.A. ,   Ain Shams University, Egypt, Farid L.A. ,   Ain Shams University, Egypt
Published: August 2023

Objective. Evaluation of the efficacy of low-dose dexamethasone on ovarian response and pregnancy outcome in infertile patients with type A polycystic ovarian syndrome (PCOS). Patients and methods. The study included infertile patients with type A PCOS who were candidates for in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) using a fixed GnRH antagonist protocol. The patients were randomized into two groups: a low-dose steroid group of 80 women with type A PCOS undergoing a trial of IVF/ICSI who received two tablets of 0.5 mg dexamethasone every evening from the first day of gonadotropin administration till the night before oocyte retrieval with a GnRH antagonist controlled ovarian hyperstimulation (COH), and a placebo group of 80 women with type A PCOS undergoing IVF/ICSI who received two tablets of placebo from the first day of gonadotropin administration until the night of oocyte retrieval. Results. In the low-dose dexamethasone group, the duration of stimulation was statistically significantly shorter, and there were significantly fewer stimulation ampoules; however, E2 levels on the day of ovulation induction, fertilization rate, and the number of retrieved M2 and fertilized oocytes were significantly higher compared to the placebo group. On the other hand, there was no significant difference between both groups regarding the incidence of ovarian hyperstimulation syndrome (OHSS) and the rate of embryo transfer. Conclusion. Dexamethasone improves embryo quality and pregnancy rate; additionally, it minimizes the number of gonadotropin ampoules used for stimulation. Thus, we suggest the use of dexamethasone in women with PCOS undergoing IVF/ICSI treatment. Key words: low-dose dexamethasone; type A PCOS; IVF/ICSI; antagonist protocol
Nausea and vomiting of pregnancy: impact on quality of life
Authors:   Tula State University, Tula, Russian Federation, Khabarov S.V. ,   Federal Scientific and Clinical Center for Specialized Types of Medical Care and Medical Technologies, Federal Medical-Biological Agency of Russia, Moscow, Russian Federation,   VitroClinic, Network of IVF Clinics “Genome”, Group of Medical Companies “MEDMA”, Moscow, Russian Federation
Published: August 2023

Objective. To examine the relationship between nausea and vomiting of pregnancy (NVP) of varying severity and health-related quality of life (QoL), as well as the efficacy of improving it with the Preginor® complex. Patients and methods. A prospective cohort study enrolled 94 women at 6 to 16 weeks’ gestation with mild to moderate nausea and/or vomiting. The clinical status of patients and QoL were assessed by questionnaire before, during and after administration of Preginor® with evaluating the Pregnancy–Unique Quantification of Emesis and Nausea/PUQE index and socioeconomic status, habits, and lifestyle from specialized questionnaires. Results. Based on the total PUQE index, 69.1% of pregnant women had mild nausea and vomiting. Moderate NVP accounted for 30.9%. No cases of severe NVP that might require hospitalization were identified. In the calculation, the average PUQE score before the use of Preginor® was 6.5. By the end of treatment, the mean value of NVP index decreased by 2.2 times; 37.2% of patients had no complaints, while 55.3% only experienced mild nausea. In 7.5% of women, even with the persistence of moderate manifestations of NVP, their intensity was significantly reduced, improving the general condition of pregnant women and increasing their QoL. In some patients, the Preginor® complex could be continued for more than 1 month upon the recommendation of the attending physician. Conclusion. According to the data presented, NVP, the intensity of which can be measured by the PUQE index, has a significant impact on various aspects of women’s lives, including global QoL, day-to-day aspects, and readiness to become pregnant again. A decrease in this index during the treatment of NVP is associated with an improvement in physical and mental QoL. For this reason, the NVP-specific PUQE index can be a very useful tool in clinical practice. The use of Preginor® complex for nausea and vomiting during pregnancy, significantly alleviating these symptoms, improves patients’ quality of life and daily activities. Key words: nausea, vomiting, pregnancy, antiemetics, ginger, Preginor®, quality of life
Early-term infants: ways to reduce morbidity and mortality in full-term infants
Authors:   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Ivanov D.O. , Sofronova L.N. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Pavlova S.E. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Libova T.A. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Rukhliada N.N. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Prokhorovich T.I. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Khavkin A.I. ,   Research Clinical Institute of Childhood, Ministry of Health of the Moscow Region, Moscow, Russian Federation,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation
Published: August 2023

This review summarizes the literature data on a specific group of newborns, “early term”, according to the current classification of newborns based on the gestational age at birth. It is shown that infants born early in a full-term pregnancy (37–38 weeks) have significant risks for survival and further development as compared with the “full-term” group. Particular attention is paid to the causes of early-term birth in the context of the optimal gestational age in a normal pregnancy. In addition, recommendations for the practical management of early-term infants are presented, as well as preventive measures aimed at reducing iatrogenic causes of early-term birth. Key words: full-term infants, early-term birth, early-term newborns, neonatal mortality, neonatal morbidity, infant mortality
The The Implications of Transformational and Transactional Leadership on Organizational Commitment
Authors: Asrarudin
Published: August 2023

Abstract

 

This research is a literature review that examines various literatures on the implication transformational and transactional leadership. The purpose of this research is to find out the implications of transformational and transactional leadership on organizational commitment; similarities and differences behaviors of transformational and transactional leadership towards organizational commitment. The method used in this research is integrative literature review which assesses, criticizes, and synthesizes different literatures to create new theoretical framework. This research finding shows that transformational and transactional leadership have implications on the commitment of each employee to the values ​​and goals of the organization. Transformational leadership builds long-term relationship while transactional leadership builds short-term relationships with subordinates based on shared goals and rewards are given when subordinates are able to achieve goals and vice versa sanctions are given if the goals cannot be achieved. Creative and innovative behavior is not the main thing but status quo is important.
The Effect of Customer Trust and Product Diversity on Shopee Users Repurchase Intention with Customer Satisfaction as a Moderating Variable
Authors: Isma Maisarah  , Yani Ari Soeti
Published: August 2023

This study aims to test and analyze the effect of discounts and sales promotion on repurchase intention with customer satisfaction as a moderating variable. The population in this study used a sample of 344 respondents who were users of the Shopee application aged 18-28 years. The data collection technique uses simple random sampling by spreading research questionnaires in the form of google forms through social media. The data processing method in this study is to use smartPLS with the aim of testing hypotheses. The results of this study show that customer trust has a positive and significant effect on repurchase intention, product diversity has a positive and significant effect on repurchase intention, customer satisfaction has a positive and significant effect on repurchase intention, customer satisfaction is significant and can moderate the effect of customer trust on repurchase intention, customer satisfaction has a significant effect on repurchase intention and can moderate the effect of product diversity on repurchase intention. This research recommends to shopee if you want to increase consumer repurchase interest, then it is possible to be able to further increase the sense of customer trust, because some respondents to this study stated that shopee has not fully provided quality products so that the products purchased are not in accordance with expectations, but this can be minimized by checking and ensuring that each product is worthy of being traded. Shopee is also expected to maintain the level of product availability, so that consumers can feel satisfied and return to shopping.Customer Trust, Product Diversity, Repurchase Intention, Customer Satisfaction
The Influence of Emotional Intelligence, Organizational Culture and Team Work On Employee Performance at The Royale Krakatau Hotel, Cilegon
Authors: Pancasasti Ranthy , Putra Aries Pratama , Nuraisah Fitri , Khalqiyah Sofwah
Published: August 2023

The purpose of this study is to analyze a model that is expected to improve employee performance by involving emotional intelligence, organizational culture and teamwork.

Originality/value: Novelty in this research is that no previous research has been found that discusses emotional intelligence, organizational culture and teamwork on Employee Performance at The Royale Krakatau Hotel, Cilegon.

Research limitations: The limitations of this study are only to analyze the influence of emotional intelligence, organizational culture and teamwork on employee performance at The Royale Krakatau Hotel, Cilegon.

Design / methodology / approach: The research method is quantitatively by using a questionnaire with an Ordinal scale of 10 points and the sampling technique was carried out by simple random sampling. The number of samples used was 120 employees to test the four (4) predetermined hypotheses. The Structural Equation Model-Partial Least Square (SEM-PLS) model was used to test the statistical significance of the path coefficient.

Findings: The findings of the study explain that Emotional Intelligence has a not significant positive effect on Employee Performance, Organizational Culture has an insignificant positive effect on Employee Performance, Emotional intelligence has a positive and significant effect on Organizational Culture, Emotional Intelligence has a positive and significant effect on Teamwork, Organizational Culture has a positive and significant effect on Teamwork, Teamwork has a positive and insignificant effect on Employee Performance.
Machiavellian, Organizational Commitment, Retaliation, Self-Efficacy, Religiosity and Intention Whistleblowing
Authors: Hakim Luqman , Natasya Fikri Adhelia , Tantri Mitsalina
Published: August 2023

This study aims to determine the effect, (1) nature machiavellian on intention whistleblowing, (2) organizational commitment to intention whistleblowing, (3) retaliation to intention whistleblowing, (4) self-efficacy on intention whistleblowing, (5) religiosity towards intention whistleblowing. This research is a type of quantitative research. The data collection method used is primary data obtained by using a questionnaire. The population in this study are internal auditors who work in companies in the South Jakarta area and are registered with the Internal Audit Education Foundation (YPIA) and have worked for more than 1 year. The sampling technique used is purposive sampling with sampling quotas which produced 36 respondents. This test uses SPSS Version 25 as a data analysis tool. The results of this study indicate that (1) Nature machiavellian no effect on intention whistleblowing, (2) Organizational commitment affects intention whistleblowing, (3) Retaliation affects intention whistleblowing, (4) Self-efficacyno effect on intention whistleblowing, and (5) Religiosity has no effect on intention whistleblowing.
Institutional Conflict in Employee Output, Absenteeism and Turnover
Authors: Owusu-Acheampong Eugene , Antwi Joseph
Published: August 2023

Abstract

This study aimed to examine the effect of conflict on employee output, absenteeism and turnover. The study was quantitative, and the design was a descriptive survey. The population for the study was stratified, and the study participants were selected randomly. The instrument was a questionnaire, and the IBM SPSS version 22 was used to generate the results for discussion. The study revealed that conflict adversely influences employee performance and also accounts for frequent employee absenteeism, low output and turnover. One implication for leadership from the study is that workplace conflicts significantly affect employee output, absenteeism and turnover. Each employee faces different conflicts that must be understood and resolved. By implication, organisational leaders must design jobs appropriately for employees to prevent duplications and foster peaceful collaboration among employees. This will help them build trust among themselves at the workplace. This will reduce interpersonal, relationship and task-related conflicts within the organisation. This will minimise conflict and its dysfunctional consequences on the employees and the organisation. Literature on the conflict in higher institutions appears to be scarce in Ghana. This study is different as it examines the relationship between conflict and employee performance using work output, absenteeism and turnover in technical universities in Ghana.
CIPPO Model Evaluation on the English Language Training Program At the Indonesian Navy Education Services
Authors: Kusmiyati Nani , Hamidah  , Kadir
Published: August 2023

This study describes the implementation of the English Language Education and Training program at the Indonesian Navy Education Service for Indonesian Navy personnel. This study applies a descriptive qualitative method using the CIPPO model (Context, Input, Process, Product and Outcome). To get the data, the researchers conducted interviews, observation, documentation, focus group discussions and questionnaires. From the data obtained through interviews, observation, documentation, focus group discussions and CIPPO model questionnaires using a Likert scale (1 to 5) the context aspect shows 3.81, the training has been carried out based on the objectives, educational plans and activity plans. The input aspect shows 3.59, it supports the training process. The process aspect shows 3.82, the training process can run smoothly. The product aspect shows 3.96, the results of the training are satisfactory. The outcome aspect shows 3.95, the training has a good impact on human resources and institutions in the Navy. This research has the novelty that English Education and Training at DISDIKAL really needs an in-depth evaluation of the implementation of Education and Training. So far, the evaluation is still based on reports on the completion of training