bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of Sulfur (S) – Silicate (Si) Fertilizer Application on The Growth, Yield, and Physiochemical Properties of Two Soybean Varieties
Authors: Slameto Slameto
Published: January 2025

Soybeans are a food ingredient with a high level of consumption in Indonesia. Low soybean production needs to be increased in productivity and quality by managing soil fertility through fertilization. This research aims to determine the effect of applying Sulfur-Silicate fertilizer to two soybean cultivars, Devon and Dena, and their interaction on soybean productivity and quality. The method used in this research was a randomized block design with 2 treatment factors, namely soybean variety and Si-S fertilizer concentration. The level of treatment for the soybean varieties used are the Devon and Dena1 varieties. The Si-S fertilizer concentration levels tested were without fertilizer, Si-S 110mg/L-23 mg/L; 133 mg/L-30.7 mg/L; 200 mg/L-46 mg/L. Data were analyzed statistically and processed using Duncan's multiple range test. Treatment of Si-S 200 mg/L - 46 mg/L on Devon soybeans increased the average Plant Height to 91.00 cm, Plant Diameter to 0.90 cm, Number of Leaves to 72.0, Number of Branches to 5.33, and the chlorophyll content becomes 35.50, while Dena1 soybeans were 85.0 cm, 0.90 cm, 80.6 cm, 5.6 and 36.50 respectively. Treatment using 110mg/L-23 mg/L Si-S fertilizer increased seed weight, number of pods per plant and weight of 100 seeds. The results of the research show that applying Si-S fertilizer to Dena1 variety soybean plants can increase productivity in terms of the number of pods and seed weight. It is hoped that these results will provide education to farmers regarding the application of Si-S fertilizer and soybean varieties to increase soybean yield and quality.
Pengaruh Komposisi Media Tanam dan Konsentrasi Pupuk Organik Cair Berbahan Daun Gamal (Gliricidia sepium) Terhadap Pertumbuhan dan Hasil Tanaman Sawi (Brassica juncea L.)
Authors: Priyambodo Bagus , Hariyono Kacung K
Published: January 2025

Mustard productivity in Indonesia tends to increase in 2019 by 10.72 tons/ha. However, this number is still below the yield potential of one of the national mustard varieties, namely the Puteri variety (PT Bintang Citra Asia), which has a yield potential of 20-25 tons/ha. An effort is needed to increase the productivity of national mustard by using liquid organic fertilizer (LOF) gamal leaves and managing the composition of the planting media. This study aims to determine the effect of the ratio between the doses of liquid organic fertilizer gamal leaves and the composition of the planting medium (soil, cow dung and husk charcoal) on polybag mustard plants. This study used CRD (completely randomized design) with 2 factors. The first factor is the planting medium (M) with 4 levels, namely soil (M0), soil + cow dung + husk charcoal = 1:1:1 (M1), 1:1:2 (M2), and 1:2:1 (M3) ). The second factor was gamal leaf POC (K) with 4 levels, namely without fertilizer application (K0), 80 ml/L (K1), 160 ml/L (K2) and 240 ml/L (K3). The data was then tested using ANOVA and 95% DMRT follow-up test. Treatment M3 and K3 were the best treatments for variable plant height, number of leaves, leaf width, leaf area index, fresh weight and dry weight. The interaction of the two M3K3 factors resulted in the highest average values for the 4 observational variables, namely plant height of 32.7 cm, leaf area index of 0.171 cm2, wet weight of 105.2 grams and dry weight of 8.57 grams. Soil, cow dung and rice husk charcoal and liquid organic fertilizer for gamal leaves can affect the growth and yield of mustard greens.
Pengaruh Bokashi Limbah Tongkol Jagung dan Pupuk Daun terhadap Pertumbuhan dan Hasil Kacang Edamame di Tanah Pasir Pantai
Authors: Faozi Khavid , Tini Etik Wukir , Supartoto Supartoto , Cendani Rizqianida Arum
Published: January 2025

The aim of the study was to determine the dose of corncob waste bokashi and foliar fertilizers application that increased the growth and yield of edamame beans. The research was conducted at the plastic house of the Faculty of Agriculture, Jenderal Soedirman University, Banyumas Regency, Central Java, Indonesia, from November 2020 to January 2021. The pot experiment was arranged in a Randomized Block Design (RBD) with two factors and three replications. The first factor was the level of bokashi consist of 10 (B1), 30 (B2), and 50 t.ha-1 (B3). The second factor was the frequency of foliar fertilizers, i.e control/without treatment (F0), every 5 days (F1), and once every 10 days (F2). Data were analyzed by F test and if significantly different, continued with duncan multiple range test (DMRT) at an error level of 5%. The results showed that the application of corncob waste bokashi increased leaf area by 21.0%, fresh and dry shoot weights 47.9% and 49.0%, fresh and dry root weights 78.5% and 50.3%, number of pods per plant by 45,0%, and pod weight per plant by 58.3%. The application of foliar fertilizer only increased the fresh root weight by 45.4%. There was no interaction between corncob waste bokashi dose and foliar fertilizer frequency on all growth and yield variables of edamame beans.
Klasifikasi Genom dan Hubungan Kekerabatan Tanaman Pisang (Musa spp.) di Kabupaten Rokan Hulu berdasarkan Karakter Morfologi
Authors: Zulfahmi Zulfahmi , Nurliana Nurliana , Rosmaina Rosmaina
Published: January 2025

Banana is a fruit crop cultivated by the community of rokan hulu from generation to generation. The knowledge comprehensive on the banana crop in Rokan Hulu Regency is unavailable and its information an important to conservation and breeding program in the future. This study aimed to determine the genome classification and the genetic relationship among banana cultivars (Musa spp.) at Rokan Hulu District. The morphological characterization was performed by following the International Plant Genetic Resource Institute (IPGRI) standard. This study has successfully identified sixteen local banana cultivars. Based on morphological character that sixteen banana cultivars can be grouped into three genomes, first group was AA/AAA genome that consisted of Lidi, Somanih, Sminyak, Lomakmanih, and Pinang banana cultivars, second group was AAB genome that consisted of Sawak, Kapas, Bunga, Barangan, Udang, Raja, Mantan, Nangka, and Kapal cultivars, and last group was ABB genome that consisted of Batu and Kepok banana cultivars. The morphology similarity among cultivars ranged from 0.49 to 0.98. The lowest value of morphology similarity was observed between Nangka and Udang cultivars, meanwhile, the highest value of morphology similarity was observed between Mantan and Somanih cultivars. Dendrogram UPGMA based on morphological similarity (68%) clustered all cultivars into four main groups. The first cluster consisted of Batu, Raja, Nangka, Barangan, and Kapas banana cultivars, The second group consisted of Sawak and Pinang banana cultivars. The third group consisted of Lomakmanih, Sminyak, Mantan, Lidi, Kapal, and Somanih banana cultivars, and the fourth group consisted of Bunga dan Udang banana cultivar. The clustering result did not reflected genome classification of banana cultivar. The results of this study could be used as the basic information to formulate the breeding and conservation strategies of banana in Rokan Hulu regency in the future.
Keragaman Genetik dan Heritabilitas Berbagai Karakter Tanaman Kedelai (Glycine max (L.) Merril)
Authors: Deviona Deviona , Roslim Dewi Indriyani , Zul Delita , Suhartina Suhartina , Syafitri Artica Ria
Published: January 2025

The purpose of this study was to determine the genetic diversity and heritability values of the morphological characters of several genotypes of soybean plants. The study used a completely randomized design (CRD) consisting of fourteen genotypes and three replications. The observed parameters were flowering age, harvesting age, plant height, number of nodes, crown width, stem diameter, number of fruitful pods per plant, total number of pods per plant, total number of seeds per plant, number of fruitful seeds per plant, number of seeds per pods, 100 seed weight, and seed weight per plant. Data were analyzed by analysis of variance using SAS version 9.0, followed by Duncan's multiple range test (DNMRT) at the 5% level. The results showed that the characters were flowering age, harvesting age, plant height, number of nodes, stem diameter, total number of pods per plant, number of seed pods per plant, total number of seeds per plant, number of seeds per plant, number of seeds per pod, weight seed per plant, has a wide genetic diversity. Crown width characteristics have narrow genetic diversity. All characters showed wide phenotypic diversity. The heritability results showed that the characteristics were flowering age, harvesting age, plant height, number of nodes, crown width, stem diameter, total number of pods per plant, number of seed pods per plant, total number of seeds per plant, number of seeds per plant, and number of seeds per plant. Pods and seed weight per plant were classified as having a high heritability. The characteristics of flowering age, harvesting age, plant height, number of nodes, stem diameter, total number of pods per plant, number of fruitful pods per plant, total number of seeds per plant, number of fruitful seeds per plant, number of seeds per pod, and seed weight per plant can be used as selection criteria because they have a wide genetic diversity and high heritability value.
INVESTIGATING THE IRAN PRESIDENTIAL HELICOPTER CRASH (2024): CAUSES, GEOPOLITICAL DYNAMICS, AND POLICY IMPACTS
Authors: Siagian Ruben Cornelius , Rajagukguk Michael Haratua
Published: January 2025

This study investigates the helicopter crash that killed the Iranian President and seven others during a dam inauguration near the Azerbaijan border on May 9, 2024. The research examines factors contributing to the accident, including technical failures, weather conditions, human error, and potential external involvement, within the frameworks of aviation safety theory, geopolitical analysis, and crisis management. Using a multidisciplinary approach and secondary data analysis, the study identifies causal factors, evaluates their implications for aviation policies, and explores the political dynamics arising from the incident. Findings indicate that severe weather conditions, challenging topography, and possible operational errors contributed significantly to the crash. Additionally, speculation about external interference highlights the geopolitical tensions surrounding the event. The incident underscores the need for enhanced aviation safety measures and effective crisis management strategies, particularly in politically sensitive regions like the Middle East.
The Dark Side of Social Media: Analysing Dark Pattern Combinations and Their Impacts
Authors: Ukgoda Hansika
Published: January 2025

In today’s digital era, technology is essential in daily life, transforming interactions and activities. However, the rise of “Dark Patterns - deceptive design practices in websites and apps raises significant ethical concerns. Originally defined by User Experience Designer Harry Bringull, dark patterns manipulate users into actions like involuntary purchases and subscriptions. This study explored dark patterns on social media networking sites (SNSs), focusing on two key questions: Do platforms use specific dark patterns in combination, and how do these combinations impact user interaction and experience?
Utilizing cognitive walkthroughs with UI/UX experts, this research examined dark patterns on YouTube, LinkedIn, Telegram, and WhatsApp. Researchers conducted platform-specific evaluations to examine and understand the various combinations of manipulative design elements. The findings revealed prevalent combinations of dark patterns and evaluated their effect, addressing a critical gap concerning social media's ethical implications in the Human-Computer Interaction (HCI) field. The findings contribute to disclosing ethical design practices and promoting a more user-friendly approach to UI design that enhances user well-being and trust in digital environments.
Sentiment Analysis of Netizens on Constitutional Court Rulings in the 2024 Presidential Election
Authors: Ariannor Wahyudi , Alshalwi Sami M A B , Susarianto Budi
Published: January 2025

Abstract

<span style="font-size: 9.0pt; font-family: 'Times New Roman',serif; mso-fareast-font-family: 'Times New Roman'; mso-ansi-language: EN-GB; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;" lang="EN-GB">Online conversations among netizens play an important role in forming collective opinions and views about important events, including judicial decisions such as those taken by the Constitutional Court (MK). This research explores sentiment analysis of the Constitutional Court’s decisions, especially in the context of the presidential election, using the Support Vector Machine (SVM), Logistic Regression, and Naive Bayes algorithms. Previous studies on public sentiment toward the Constitutional Court’s decision provide a basis. Still, this research focuses on a different context, analysing sentiment toward the Constitutional Court’s decision in the 2024 presidential election dispute. This study adopts an experimental methodology, involving several key stages such as data collection through Twitter web scraping, labelling, pre-processing, TF-IDF weighting, and algorithm testing. Evaluation using a confusion matrix shows comparable accuracy among SVM, Logistic Regression, and Naive Bayes, with SVM and Logistic Regression demonstrating superior precision and F1 scores. Negative sentiment carries greater weight than neutral and positive sentiment, highlighting potential social tensions and the need for effective communication and deeper analysis to understand the root causes of negativity. The SVM and logistic regression algorithms have proven effective in understanding public sentiment towards the Constitutional Court’s decisions in a political context, providing valuable insights for understanding the dynamics of public opinion.
Transmisión materno fetal y SARS-COV-2: un estudio bibliométrico
Authors:   , Lopez Carhuatocto Lucero , Santos Lescano Claudia Nahomi
Published: January 2025

Objetivo: Este estudio tuvo como objetivo analizar la producción científica existente sobre Transmisión Materno fetal y SARS-CoV-2. Materiales y métodos: Los datos se obtuvieron de la base de datos Scopus a través de una búsqueda exhaustiva usando las palabras claves “Maternal- fetal transmission” AND “SARS-CoV-2” y sus sinónimos. El intervalo de tiempo fue desde enero de 2020 a febrero del año 2024. Se utilizó el programa Microsoft Excel 365 para análisis descriptivo. Resultados: Obtuvimos 1698 publicaciones entre 2019 y 2023. Estados Unidos fue el país que presentó la mayor cantidad de publicaciones (24.97%). Journal Of Maternal Fetal And Neonatal Medicine, American Journal Of Obstetrics and Gynecology y American Journal of perinatology fueron las tres principales revistas que publicaron más documentos acerca del tema. La publicación más citada fue “Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records” de H. Chen, que se publicó en el año 2020. Las 10 principales instituciones se ubican principalmente en China y Estados Unidos. David Schwartz fue el investigador más productivo sobre Transmisión vertical y Covid-19. Y los 5 principales autores provienen, en su mayoría, de Francia. Conclusión: Este estudio proporciona datos importantes y un análisis integral en cuanto a las publicaciones sobre Transmisión materno fetal y SARS-CoV-2 para médicos, investigadores y/u obstétricos para identificar países y autores con quienes colaborar en futuras investigaciones en este rubro.
SOCIO SCIENCE-TEACHING ON MADURA BULL RACING CONTEXT: FINDING CORRELATION BETWEEN NUMERACY LITERACY AND SCIENCE CONCEPTUAL UNDERSTANDING
Authors: Mochammad Yasir  , Dwiyanti Lusiana
Published: January 2025

The Madura bull racing as the local wisdom of Madura can be studied scientifically to train students in numeracy literacy and understanding concepts. Numerical literacy is important for students because it includes basic skills for obtaining new information. Numerical literacy is not only needed in mathematics, but is also needed to learn concepts in science subjects. The purpose of this study was to determine the relationship between numeracy literacy skills and students' understanding of science concepts towards the concept of motion and force in socio-science teaching in the Madura bull racing context. Data analysis used Spearman's rank correlation test. The results showed a significance value of 0.000 <0.05 with a correlation coefficient of 0.528, which means that there is a positive relationship with moderate closeness between numeracy literacy skills and understanding of the science concept of motion and force socio-science teaching in the Madura bull racing context with a determination coefficient of 0.278. The conclusion of this study is that the correlation of numeracy skills on students' understanding of science concepts regarding motion and force socio-science teaching in the Madura bull racing context is 27.88% and 72.12% is influenced by other factors, such as multi-representational skills, HOTs, etc. This research has implications for improving science learning designs using the context of the local wisdom of Madura bull racing in training science conceptual understanding and numeracy literacy skills.
WITHDRAWN: Helicobacter Pylori-Vacuolating Cytotoxin A Inducing Neurotoxic Neuroinflammation in Human Stomach-Brain Axis
Authors: Tran Van Thi Ai , Etemadi Niloofar , Tran Minh , Lee Jungmi , Ko Han Seok , Jo Donggyu , Lee Luke P. , Cho Hansang
Published: January 2025

The full text of this preprint has been withdrawn by the authors in order to comply with an institutional policy on preprints. Therefore, the authors do not wish this work to be cited as a reference.
A Bibliometric Insight into Immersive Technologies for Cultural Heritage Preservation
Authors: Jiang Leilei , Li Jingjing , Lobo Joseph , Tanucan Jem Cloyd M. , Wider Walton , Zou Rong
Published: January 2025

This study utilized bibliometric analysis to identify emerging trends and future directions in using immersive technologies for cultural heritage preservation. Its goal was to identify key research developments and gaps and suggest future research directions. The research uses a bibliometric approach to synthesize existing literature from the Web of Science database until December 31, 2023. Bibliographic coupling and co-word analysis were used to evaluate these fields' current and future trends. The analysis revealed a significant increase in publications in recent years, indicating significant interest and progress in using immersive technologies for cultural preservation. Bibliographic coupling identified five clusters focusing on technological applications for tangible and intangible heritage preservation. In comparison, co-word analysis revealed four clusters related to digital replication, public engagement, and educational use of immersive experiences. The study emphasizes the shift from traditional preservation methods to more dynamic, interactive approaches that improve visitor experiences and education. This is one of the first studies to comprehensively map the bibliometric landscape of immersive technologies for cultural heritage preservation. It offers a unique perspective on how these technologies are transforming cultural heritage engagement and preservation.
Parasagittal Versus Transforaminal Epidural Steroid Injection, a Study of Contrast Flow in the Epidural Space and Clinical Outcomes: An RCT
Authors: Khojasteh Narges , Majedi Hossein , Meibodi Ali Emami , Khajehnasiri Alireza , Yekta Reza Atef , Yazdi Nader Ali Nazemian , Rahimi Mojgan , Kamali Koorosh , Abdollahi Hamed
Published: January 2025

Epidural steroid injections are frequently used to treat lumbosacral radicular pain, but the solute spread in the epidural space needs further investigation. This double-blind, randomized study assessed clinical outcomes and contrast spread patterns between the parasagittal interlaminar and transforaminal approaches in 79 adults with low back pain due to herniated or degenerated discs. Participants were randomly assigned to one of two groups: Transforaminal or Parasagittal Interlaminar. All procedures were performed under C-armed fluoroscopic guidance. Contrast spread was evaluated by a separate pain specialist, and clinical outcomes such as analgesia, patient satisfaction, and quality of life were measured at two weeks and one, three, and six months post-treatment. Results showed no statistically significant differences between the two groups in the mean pain intensity at the moment and six months after treatment (p = 0.618, p = 0.484). Comparison of contrast diffusion to the anterior epidural space between the two groups showed no statistically significant differences (P = 0.436). Clinical outcomes were similar between the two groups, but radiation exposure was significantly higher in the transforaminal group. Both approaches had the same rate of contrast flow to the anterior epidural space. However, the parasagittal interlaminar approach resulted in less radiation exposure for patients.
Internet Use and the Utilization of Home-Community Elderly Care Services in China
Authors: Xia Xueqing , Zhu Mingbao
Published: January 2025

As a key medium of the information age, the Internet has shown tremendous potential in improving the utilization of Home-Community Elderly Care Services for the older adults. This study is based on the 2018 China Longitudinal Aging Social Survey (CLASS) data, and employs the Probit regression model to explore the impact of Internet use on the utilization of Home-Community Elderly Care Services by the older adults. The study found that Internet use significantly increased the probability of older adults utilizing Home-Community Elderly Care Services. After further mitigating potential endogeneity using methods such as Propensity Score Matching (PSM) and instrumental variables, the results remained robust. Mechanism analysis revealed that Internet use promotes the utilization of Home-Community Elderly Care Services by increasing access to information and enhancing the health literacy of the older adults. Heterogeneity analysis indicated that the impact of the Internet use is greater on elderly groups that are female, have a higher level of education, and live in urban communities. To further optimize the elderly care service system, it is recommended to increase the construction of Internet infrastructure, carry out digital skills training for the older adults, and improve the transparency of service information, thereby promoting the popularization of smart elderly care services and improving the quality of life for the older adults.
Exploring the territories of climate governance: a systemic and network approach illustrated in the case of Chile
Authors: Billi Marco , Barrantes Gabriel , Orellana Paz , Bórquez Roxana , Azocar Gabriela
Published: January 2025

Meta-governance literature has sought to move towards more integrated governance approaches that overcome the current fragmentation of policies and initiatives, while recognizing the need to adjust these models to the characteristics of each specific territory. For this effort to be effective, however, it must recognize the new and heterogeneous ‘territories’ of climate change governance and its normative and socio-political implications. In light of this, we propose a novel approach based on a systemic perspective, which allows us to conceptualize governance as ‘third-order couplings’ in territorial systems. This approach is applied to the analysis of climate governance in Chile, focusing on the interactions between physical elements, ecosystem services and regulations, especially analyzing the interpenetration between water management and climate change policies. The analysis reveals spaces of fragmentation, duplication and incoherence in the domain of laws, regulations and governance actors, which are contrasted with the underlying interactions at the hydroclimatic system level. We identify three key gaps: i) the disconnect between different ‘objects’ of regulation ii) the fragmentation between actors, policies and regulatory Frameworks; and, c) the tension between conservation and adaptation. These limitations are not contingent, but rather deeply embedded in the historical way in which public bodies have observed the environment as an object of steering and regulation: as a siloed conglomerate of individual processes and domains of intervention instead than as integrated socio-ecological system. We conclude that it is essential to move towards integrated climate governance that recognises territorial interdependencies, strengthening coordinated planning and promoting a regulatory framework that reflects the complexity of socio-ecological systems.
A Car-following Model for CAVs Integrating State Information from Multiple Leading and Single Following Vehicles
Authors: Chen Yongsheng , Cheng Guozhu
Published: January 2025

To uncover the root causes of congestion in traffic flow involving connected and autonomous vehicles (CAVs) and improve stability, this study introduces the Multi-Leading and Single-Following Vehicles State Information Car-Following (MLSFICF) model for CAVs. The model is based on the classical optimal velocity car-following framework and its advanced extensions, integrating the combined effects of complete state information from multiple leading vehicles and a single following vehicle, such as headway, velocity differences, and acceleration. Linear stability analysis is used to determine the model's critical stability conditions, while nonlinear analysis derives the Korteweg-de Vries (mKdV) equation to describe the evolution of traffic congestion near these critical points. Numerical simulations indicate that the MLSFICF model achieves superior stability compared to the FVD, FVDA, BLVD, MHVD, and ACC/CACC models from the PATH laboratory. In mixed traffic conditions, higher CAV penetration rates progressively enhances traffic stability and reduces congestion. This model offers a theoretical foundation and practical guidance for simulating traffic flow involving CAVs, facilitating effective traffic management and congestion mitigation.
The long isoform of PRLR promotes tumor progression by regulating CDK6 through MAPK signal pathway in SHH medulloblastoma
Authors: Sun Ziwen , Li Haishuang , Peng Yu , Liu Yantao , Wang Yujia , Wang Jing , Liu Xiaodan , Zheng Danfeng , Liang Hui , Chang Qing
Published: January 2025

Medulloblastoma (MB) is the most common malignant brain tumors in children. Sonic Hedgehog (SHH) subgroup of MB accounts for about 25% of all MBs. SMO inhibitors are used for target therapy. However, drug resistance and toxicity occurred. New therapeutic targets are urgently needed to be developed. Here, through RNA-sequencing and Nanostring Assay analysis of primary MBs, we screened out prolactin receptor (PRLR) as a gene with higher expression level in SHH-MB compared with other subgroups of the tumor. Long isoform of PRLR (PRLR-LF) played a pivotal role in promoting SHH-MB tumor invasion, enhancing the proliferation and colony formation ability. KEGG analysis showed that PRLR-LF expression has close relationship with p53 signal pathway in SHH-MB cells. High expression of CDK6 downstream of the p53 pathway was observed to have a high correlation with PRLR expression, indicating a poor prognosis of the tumor. In addition, PRLR was demonstrated to promote cell proliferation by regulating CDK6 through Ras-MAPK signal pathway in vitro. Synthesized recombinant Δ1-11-G129R-PRL, a competitive inhibitor of PRLR, interfered PRL-PRLR binding, could inhibit the regulation to CDK6, and could and inhibit the proliferative ability of SHH-MB tumor cells. In conclusion, we unveiled PRLR promoted SHH-MB tumor progression through signaling pathway besides the canonical SHH pathway. PRLR inhibitor shed light on a potential therapeutic value for SHH-MB patients.
Therapists' Perspectives on AI Integration in Couple and Family Therapy
Authors: Aviram Alon
Published: January 2025

Objective
This study investigates therapists' perceptions and experiences using Generative AI in couple and family therapy, focusing on its benefits, challenges, and ethical considerations.
Background
As Generative AI continues to transform various industries, its application in therapeutic practices, particularly couple and family therapy (CFT), remains underexplored. CFT introduces unique dynamics and complexities, which pose specific challenges for AI integration in therapy settings.
Method
This qualitative study utilized a purposive sample of 25 experienced couple and family therapists. In-depth, semi-structured online interviews were conducted, and constructivist grounded theory was applied to analyze key themes emerging from the data.
Results
Three central themes were identified: Ethical and Privacy Concerns, the Impact of AI on the Therapeutic Relationship, and Future Directions and Worries. These themes offer a detailed understanding of AI's potential to enhance therapy while highlighting the significant risks and ethical dilemmas it introduces.
Conclusion
This study reveals that while AI can augment therapeutic practices through data-driven insights and improve intervention effectiveness, there are concerns about data confidentiality and the depersonalization of therapy. The findings underscore the need for a balanced approach to AI integration in therapy, ensuring the maintenance of the human connection central to therapeutic success.
Implications: The study emphasizes the importance of developing ethical guidelines for AI use in therapy, enhancing technological literacy among therapists, and ensuring informed client consent. Future research should explore the long-term impact of AI on therapeutic relationships and address privacy concerns, providing strategies for the ethical integration of AI in couple and family therapy.
Exploring the use of Virtual Reality to enhance rapid decompression from occupational stress during short wellness breaks for content moderators
Authors: Spence Ruth , Campbell Natalie , Woofenden Tom , Marco Jeffrey
Published: January 2025

Virtual reality (VR) has the potential to be a popular stress management tool in workplaces, however its efficacy has yet to be tested on content moderators (CMs). This study used an experimental design where CMs were randomly assigned to either: 1) VR, 2) non-screen activity or 3) control condition for a six-week period. Adherence data regarding a further four-week period was also collected and focus groups were conducted. The results demonstrated no significant differences in trait anxiety or occupational stress between baseline and follow-up for the three conditions. However, consistent with previous studies state-based stress and mood showed improvements after engaging with the activities. Specifically, participants in the VR condition showed reductions in state stress, whilst all conditions showed increases in state mood. The adherence data showed continued use of VR and non-screen activities for some CMs after the six-week experimental period finished and a focus group highlighted the logistical challenge of utilising VR setup within the allotted time. The results suggest VR may be a useful intervention for some types of occupational stress, if used during brief break times, it needs to be embedded within a logistical process that alleviates time pressure.
Feasibility of Psychiatric Consultation by Metaverse for Youths with Mental Health Conditions
Authors: Ishii Mio , Fujita Junichi , Toyohara Nao , Ide Keiko , Moroga Tomoko , Takayama Mizuho , Asami Takeshi , Miyazaki Tomoyuki
Published: January 2025

Background
The unmet needs of young people for mental health services (MHSs) remain a significant issue. Despite the high demand, many young people are unable to access timely and high-quality MHS. The Metaverse, a virtual space where people interact and communicate through avatars, is expected to introduce new possibilities for MHS. This study aims to investigate the feasibility of using the Metaverse for mental health consultations with young people experiencing mental health conditions.
Methods
This qualitative observational study was conducted at a single institution via semistructured interviews. Participants aged 16–24 years who were aware of mental health conditions were assigned to experience a metaverse consultation with a psychiatrist through avatars. Afterward, participants were interviewed to assess the feasibility, usability, and influencing factors of metaverse-based consultation.
Results
Twenty-six participants were assigned, and all completed the study without any adverse psychological events. Some reported minor physical effects, such as headaches and VR-related sickness. The findings from the postinterview suggest that metaverse consultations may be particularly beneficial for individuals experiencing interpersonal anxiety, those with high sensory sensitivity due to autism spectrum disorder, those who struggle outside due to psychiatric conditions such as depression or agoraphobia, those with strong psychological resistance to receiving psychiatric care, and those who feel uncomfortable disclosing their own physical appearance in real-life settings (e.g., gender incongruence).
Conclusions
Metaverse psychiatric consultation is feasible for young people with mental health conditions, particularly for individuals with specific needs. Technical and accessibility issues must be addressed to enhance its effectiveness.
Enhancing Medication Error Reporting through Interprofessional Education: Analysis of MedWatch Reporting Accuracy and Completion Rates Between Teams and Individuals
Authors: Saad Aline H. , Bondok Rehab , Sayeg Farah , Barnes Brian J. , Rukat Caitlin , Garwood Candice , Levine Diane L.
Published: January 2025

Background: Each year, the Food and Drug Administration receives over 100,000 medication error reports, which are likely underreported. Interprofessional education (IPE) is well positioned to provide team-based training regarding medication safety and related reporting tools. This study evaluated the effectiveness of a single IPE session designed to improve the completion and accuracy of healthcare professional students’ reporting of medication errors.
Methods: An IPE session, with medical and pharmacy students, presented a case report involving a medication dispensing error that resulted in a patient’s death. The session included three components: the case presentation; a discussion of the implications of the medication error on the patient, family, and care providers; and a hands-on activity where students practiced error reporting using a simulated MedWatch platform. The students' reports were analyzed for completeness and accuracy, based on data available from the case presentation. Individual versus team submissions across disciplines were compared.
Results: Of the 701 participants who completed the session between 2021 and 2024, 225 submitted the simulated MedWatch report (32% response rate). This final sample included 111 medical students, 53 pharmacy students, and 61 interprofessional teams. The median form completion rate for teams was 88.9% compared to 55.6% for individuals. Teams demonstrated higher form accuracy rates (66.7%) compared with individuals (38.9%). Students agreed that practicing the reporting of an adverse drug event was a useful activity, while pharmacy students (p=0.014) and teams (p=0.043) felt more confident reporting an adverse drug event than medical students after this activity.
Conclusion: Following an IPE training session focused on error reporting, we observed that team-based submission of MedWatch forms resulted in improved completion and accuracy rates. Integrating an interprofessional training session focused on medication safety and error reporting in health professionals’ curricula appeared to be effective in the short term. Longer term studies are necessary to determine the impact and durability of this training.
Broadening the Perspective of Traditional Lecturing vs. Active Learning in Introductory College Biology
Authors: Aguiar Adam A. , Calabrese Jennifer
Published: January 2025

This research aimed to examine the effectiveness of traditional lectures versus active lectures in introductory college biology classes composed of science and non-science majors, a topic of significant importance in the field of education. In a traditional lecture, the researcher used PowerPoint to present class content while answering direct student questions. In contrast, an active lecture included a PowerPoint, a collaborative group activity, and class dialogue. Students were given pre- and post-class surveys to assess content learning and open-ended questions to examine learning preferences. The results demonstrate a significant increase in student understanding after both lectures, with a statistically more significant score change from the pre- to post-test for the active lecture. Moreover, students expressed a higher level of enjoyment in the active class. These findings underscore the potential of active learning in enhancing student understanding and engagement. Given the variability in learning styles, this study highlights the importance of devising mechanisms to gauge and implement the optimal extent and types of active learning strategies. The study's results suggested that reframing the active vs. traditional lecturing binary paradigm into a continuum may help instructors plan courses to best meet students' needs.
Incidence of Adverse Drug Reactions in HIV/AIDS patients in China: an active monitoring study using leveraging natural language processing and machine learning
Authors: Sun Ji , Huang Juanjuan , Ma Junlong , Qi Hui , Zhou Guoqiang , Huang Shiqiong , He Gefei
Published: January 2025

To evaluate the incidence and type with adverse drug reactions (ADRs) among HIV/AIDS patients by Hospital Intelligent Pharmacovigilance System. A retrospective analysis was performed on 3971 HIV/AIDS patients admitted to the First Hospital of Changsha in China, from January 1, 2022 to December 31, 2023. Intelligent Recognition Models with Natural Language Processing Techniques for Intelligent Monitoring Systems was used to detect ADR signals of hospital information system. The causality risk factors for the ADRs of adverse drug reactions were classified using the WHO-UMC system. Our results showed that the prevalence of ADRs was 15.69% in the patients, which mainly was predominated by skin and appendages disorders and gastrointestinal (GI) disorders (2.87% vs. 2.67% ). The most of the reactions were associated with ADR could be explained by the use of antimicrobials and antiretrovirals with by 34.92% and 26.32%, respectively. 75.36% of ADRs had occurrenceed within 14 days of hospitalization. Together, the incidence of adverse reaction ADRs of patients was significantly high during the treatment period. Moreover, the active monitoring of the CHPS system reflected the adverse reaction ADRs of patients with during COVID-19 treatment in the real world, which provided reference for clinical safe medication in clinic.
Mpox stigma in the UK and implications for future outbreak control
Authors: Paterson Amy , Cheyne Ashleigh , Tulunay Harun , Orkin Chloe , Nutland Will , Dunning Jake , Stolow Jeni , Gobat Nina , Olliaro Piero , Rojek Amanda , Group Outbreak Stigma Assessment Expert
Published: January 2025

Background
Stigma has emerged as a prominent public health challenge in the 2022–2024 global mpox outbreak, impeding outbreak control efforts and the well-being of affected individuals. Addressing stigma is a priority for improving infection prevention and control. Despite its frequent mention in public and policy discourse, robust assessment of mpox stigma is lacking. This study investigated the causes, manifestations, and public health impacts of mpox-related stigma in the United Kingdom (UK).
Methods
We conducted an online, mixed-methods cross-sectional survey to assess mpox stigma. We developed and content validated a new tool, the Stigma Survey and Community-based Assessment for New and Re-emerging outbreaks (Stigma-SCANR) for this purpose. Through quota sampling, the survey targeted populations most affected by mpox at the time of data collection (March–July 2024), including gay, bisexual, and other men who have sex with men (GBMSM), and healthcare workers.
Results
437 respondents were included. Pre-existing prejudices toward groups linked with mpox, such as GBMSM and migrants, were identified as drivers of stigma, alongside fear and misinformation. Most respondents anticipated mpox-related social stigma from a few to half of their community, and more commonly from the public rather than their own social circle. Among the 13 respondents who reported a previous mpox diagnosis, 11 (85%) had experienced mpox-related stigma. Nearly a quarter of respondents (24%) said they would not, or were unlikely to, tell a recent sexual partner about an mpox diagnosis. Feelings of shame were considered the most common barrier to care-seeking (299 respondents, 68%).
Conclusion
This analysis of mpox stigma in the UK offers insights for the current international outbreak response, particularly in countries with similarly affected communities. Lessons learnt may also be transferable to other disease outbreaks. We propose a range of practical recommendations for reducing stigma in future outbreaks, including peer support initiatives, distributing accessible information about safe timelines for returning to socialising and work or school, and co-designing public health communications and contact tracing programmes with affected community members.
Reliability and Validity of a Mobile Three-Dimensional Application for Humeral Retroversion Measurement
Authors: Kim Woo Sub , Park Soo Ji , Lee Seung Yeol
Published: January 2025

Background Humeral fractures and conditions such as Little League Shoulder are common across different age groups, necessitating accurate evaluation of humeral retroversion, especially in preoperative, intraoperative, and postoperative settings. At present, the gold-standard methods for evaluation, such as computed tomography (CT) and magnetic resonance imaging (MRI), although effective, expose patients to radiation and incur high costs, particularly in pediatric patients.Methods This retrospective study reviewed 74 patients who underwent conventional humeral AP radiography, lateral radiography, and CT between May 2020 and July 2022. Using mobile application, conventional radiography-based three-dimensional (3D) humeral reconstruction was performed. Humeral retroversion measurements obtained via the application were compared with those obtained from CT. Reliability was evaluated using intraobserver and interobserver intraclass correlation coefficients (ICCs). In addition, the correlation coefficients between the two methods were calculated.Results Mobile application showed excellent intraobserver reliability (ICC = 0.937) and high interobserver reliability (ICC = 0.901) in humeral retroversion measurements, compared to CT scans, which showed lower ICCs. In addition, no significant difference was found between the retroversion measurements using CT and the mobile application (mean difference: -0.3, p = 0.816). The correlation coefficient between the two methods was strong (0.886, p < 0.001), indicating that the application provides results comparable to those of CT.Conclusion Mobile application offers a reliable, cost-effective, and accessible alternative to CT for evaluating humeral retroversion. It demonstrates comparable accuracy while minimizing radiation exposure and costs, making it an attractive option for clinical practice and research, particularly for pediatric patients and athletes. Future prospective studies are warranted to further validate the application of the mobile application across broader clinical scenarios and establish a standardized approach for measuring retroversion.Level of evidence Level III retrospective cohort study
Rhythmic Bacteria as Biomarkers for Circadian-Related Diseases
Authors: Ubilla Pamela Karina , Ferrada Evandro , Marquet Pablo A.
Published: January 2025

Recent studies suggest that the human circadian clock influences periodic changes in the composition of the gut microbiota, which is essential for maintaining host health. This connection has led researchers to hypothesize that the disruption of the circadian clock may impact human health via the gut microbiota. Here, we hypothesize that rhythmic bacteria—those whose abundance fluctuates in a circadian pattern—are key drivers of the differences in gut microbiota composition between healthy individuals and those with circadian-related diseases. Even in the absence of a causal relation, identifying rhythmic bacteria associated with circadian-related diseases can reveal disease biomarkers as well as intervention strategies. To test this, we first conducted a systematic review to identify rhythmic bacteria reported in the literature. Then, we mapped these bacteria onto a reference gut microbiota dataset of nearly 4,800 healthy individuals from a previously curated metagenomic database. We use this data to assess the prevalence and abundance of bacteria. To examine significant bacteria in samples from individuals with circadian-related diseases, including type 2 diabetes, hypertension, atherosclerotic cardiovascular disease, colorectal cancer, metabolic syndrome, and inflammatory bowel disease, we compared disease datasets from several previous studies with their respective healthy controls. Of the eight rhythmic bacteria identified in previous studies, seven were among the top 100 most prevalent and abundant species in the gut. We found the rhythmic bacterium Roseburia faecis to be strongly and exclusively associated with circadian-related diseases, suggesting its use as a biomarker and possibly coadjuvant in the treatment of these diseases. Clinical trial number: not applicable.
Global research trends and priorities in the link between Toll-like receptors and rheumatoid arthritis: a bibliometric analysis from 2003 to 2023
Authors: Zong Yanping , Li Hui , Chang Yonglong , Zhang Xiaojun , Guo Jinchen
Published: January 2025

Background: Rheumatoid arthritis (RA) is a widespread chronic autoimmune disease, distinguished by inflammation in the synovial membrane. Research indicates that Toll-like receptors (TLRs), which engage with internal ligands generated by the body, serve a crucial function in triggering immune reactions. These receptors are also implicated in the onset of inflammatory conditions, injuries, tumors, and are pivotal to the development of RA. This research seeks to comprehensively examine the present status and evolving trends in the study of the relationship between rheumatoid arthritis and Toll-like receptors using bibliometric methods.
Methods: Research on rheumatoid arthritis and Toll-like receptors was conducted using the Web of Science Core Collection (WoSCC) database, covering the period from 2003 to 2023. Eligible articles were screened according to predefined criteria and analyzed bibliometrically using VOSviewer, CiteSpace and the R package “bibliometrix”.
Results: 440 papers from 56 countries or regions, 670 institutions, and 2264 authors in the disciplines of biochemistry and molecular biology, chemistry, engineering, immunology, and materials science were included. The United States, China and the Netherlands were the primary contributors. The institution that published the most papers in the field was Radboud Univ Nijmegen from the Netherlands. Prof. Van Den Berg Wim B from Radboud University Nijmegen Medical Center was the most prolific scholar. Research on TLRs and the immune-inflammatory response, interaction of TLRs with immune cells, regulation of TLRs signaling pathways, and TLRs and RA therapy in RA are hot topics in this field. The development trend is shifting from pathogenesis to targeted therapy.
Conclusion: The involvement of Toll-like receptor-mediated immune inflammation in the development of rheumatoid arthritis has become a research focus of multidisciplinary interest. This article summarizes the research institutions, authors, journals, hotspots and application trends of Toll-like receptors in rheumatoid arthritis, which will help researchers to conduct further studies.