bluuebunny/crossref_metadata_2025 huggingface dataset:
An efficient computational framework for naval shape design and optimization problems by means of data-driven reduced order modeling techniques
Authors: Demo Nicola , Ortali Giulio , Gustin Gianluca , Rozza Gianluigi , Lavini Gianpiero
Published: November 2020

This contribution describes the implementation of a data-driven shape optimization pipeline in a naval architecture application. We adopt reduced order models in order to improve the efficiency of the overall optimization, keeping a modular and equation-free nature to target the industrial demand. We applied the above mentioned pipeline to a realistic cruise ship in order to reduce the total drag. We begin by defining the design space, generated by deforming an initial shape in a parametric way using free form deformation. The evaluation of the performance of each new hull is determined by simulating the flux via finite volume discretization of a two-phase (water and air) fluid. Since the fluid dynamics model can result very expensive—especially dealing with complex industrial geometries—we propose also a dynamic mode decomposition enhancement to reduce the computational cost of a single numerical simulation. The real-time computation is finally achieved by means of proper orthogonal decomposition with Gaussian process regression technique. Thanks to the quick approximation, a genetic optimization algorithm becomes feasible to converge towards the optimal shape.
Delinquency in Emerging Adulthood: Insights into Trajectories of Young Adults in a German Sample and Implications for Measuring Continuity of Offending
Authors: Kessler Georg
Published: November 2020

The majority of studies within the framework ofDevelopmental and Life-Course Criminologyfocus on adolescence. There are even fewer studies that deal with heterotypic measures of delinquency. This study fills a gap in the literature by targeting exclusively the period of emerging adulthood (ages 18 to 28) and scrutinizing different trajectories and patterns of offending (offending portfolios) thereof. We discuss the topic of continuity of offending with changing opportunity structures for an adult population via contrast of one set of delinquent behaviors reflecting opportunity structures in adolescence (youth set) and one where adult-appropriate criminal activities were added (total set). We applied latent class growth analysis (LCGA) to both sets in a sample of 1810 German men and women aged 18 to 28 years. During emerging adulthood, average crime versatility and incidences increase slightly with items of the total set, while it decreases with only the youth set. LCGA on the total set reveals five meaningful trajectories with declining but also increasing slopes. Among these is one trajectory of innocuous adolescents, who start an offending career with mainly adult crimes during emerging adulthood. Of the sample, 45.25% reported at least one offense during that period. Traffic offenses and fraud are the most prevalent types of offending. While the sample’s majority is considered non-offenders, emerging adults do not entirely cease to commit offenses. Instead, they shift their preference towards age-appropriate and covert ways to act anti-socially. Trajectory groups reflect proclivities towards either youth, adult, or a mix of both types of crime.
Hayabusa2’s superior solar conjunction mission operations: planning and post-operation results
Authors: Soldini Stefania , Takeuchi Hiroshi , Taniguchi Sho , Kikuchi Shota , Takei Yuto , Ono Go , Nakano Masaya , Ohnishi Takafumi , Saiki Takanao , Tsuda Yuichi , Terui Fuyuto , Ogawa Naoko , Mimasu Yuya , Takahashi Tadateru , Fujii Atsushi , Nakazawa Satoru , Yoshikawa Kent , Oki Yusuke , Hirose Chikako , Sawada Hirotaka , Yamaguchi Tomohiro , Yoshikawa Makoto
Published: November 2020

In late 2018, the asteroid Ryugu was in the Sun’s shadow during the superior solar conjunction phase. As the Sun-Earth-Ryugu angle decreased to below 3°, the Hayabusa2 spacecraft experienced 21 days of planned blackout in the Earth-probe communication link. This was the first time a spacecraft had experienced solar conjunction while hovering around a minor body. For the safety of the spacecraft, a low energy transfer trajectory named Ayu was designed in the Hill reference frame to increase its altitude from 20 to 110 km. The trajectory was planned with the newly developed optNEAR tool and validated with real time data. This article shows the results of the conjunction operation, from planning to flight data.
The Unknown Enemy
Authors: Tripodi Christian
Published: November 2020

Western counterinsurgency doctrine proposes that cultural intelligence is an important requirement for those forces operating amidst the unfamiliar socio-political structures often found in distant conflict zones. Yet while the determination to understand the intricate nature of alien societies may appear a rational undertaking in such circumstances, Christian Tripodi argues that these endeavours rarely help deliver success. The frictions of war and the complex human, cultural and political 'terrain' of the operating environment render such efforts highly problematic. In their attempts to generate and instrumentalize local knowledge for the purpose of exerting influence and control, western military actors are drawn into the unwelcome realm of counterinsurgency as a form of political warfare. Their operating environment now becomes a space charged with phenomena that they rarely comprehend, rarely even see and which they struggle to exert any meaningful control over. All in pursuit of a victory that might literally mean nothing.
Common Pitfalls in Cognitive and Behavioral Neurology
Authors: Josephs Keith , Rodriguez-Porcel Federico , Shatz Rhonna , Weintraub Daniel , Espay Alberto
Published: November 2020

Clinical case studies are fundamental in cementing theoretical training, especially for neurological disorders where diagnosis can be difficult. This book describes a variety of clinical scenarios associated with either the misdiagnosis or incorrect management of cognitive and behavioral neurological syndromes, identifying common pitfalls, which are discussed in detail. Each case emphasizes the importance of information derived from the patient's history and physical examination in forming a correct diagnosis. Focusing on disorders and presentations that are a frequent source of confusion, key diagnostic principles are illustrated clearly. Questions to the reader move the narrative along logically, whilst highlighting specific aspects of clinical presentation that lead to the correct diagnosis. Videos of patients connect readers to the cases and demonstrate how to avoid diagnostic pitfalls. An online version of the book can be accessed on Cambridge Core, via the code printed on the inside of the cover.
New synthetic fiber armored cable for freezing-in thermal ice probes
Authors: Zhang Nan , Liu Hui , Talalay Pavel , Sun Youhong , Li Na , Fan Xiaopeng , Li Bing , Gong Da , Hong Jialin , Wang Ting , Liu An , Li Yazhou , Liu Yunchen , Wang Rusheng , Yang Yang , Wang Liang
Published: November 2020

A series of new synthetic armored cables were developed and tested to ensure that they were suitable for use with the RECoverable Autonomous Sonde (RECAS), which is a newly designed freezing-in thermal ice probe. The final version of the cable consists of two concentric conductors that can be used as the power and signal lines. Two polyfluoroalkoxy jackets are used for electrical insulation (one for insulation between conductors, and the other for insulation of the outer conductor). The outer insulation layer is coated by polyurethane jacket to seal the connections between the cable and electrical units. The 0.65 mm thick strength member is made from aramid fibers woven together. To hold these aramid fibers in place, a sheathing layer was produced from a polyamide fabric cover net. The outer diameter of the final version of the cable is ~6.1 mm. The permissible bending radius is as low as 17–20 mm. The maximal breaking force under straight tension is ~12.2 kN. The cable weight is only ~0.061 kg m−1. The mechanical and electrical properties and environmental suitability of the cable were determined through laboratory testing and joint testing with the probe.
What shapes public support for climate change mitigation policies? The role of descriptive social norms and elite cues
Authors: RINSCHEID ADRIAN , PIANTA SILVIA , WEBER ELKE U.
Published: November 2020

What are the roles of bottom-up and top-down signals in the formation of climate change policy preferences? Using a large sample of American residents (n = 1520) and combining an experimental manipulation of descriptive social norms with two choice experiments, we investigate the effects of descriptive norms and policy endorsements by key political actors on climate policy support. We study these questions in two areas considered to be central in a number of decarbonization pathways: the phase-out of fossil fuel-powered cars and the deployment of carbon capture and storage. Our study provides two important results. First, social norm interventions may be no silver bullet for increasing citizens’ support for ambitious climate policies. In fact, we not only find that climate policy support is unaffected by norm messages communicating an increased diffusion of pro-environmental behaviors, but also that norm messages communicating the prevalence of non-sustainable behaviors decrease policy support. Second, in the presence of policy endorsements by political parties, citizens’ trust in these parties influences their support for climate policies. This study contributes to research in behavioral climate policy by examining the impact of descriptive norms and elite cues on climate policy support.
THE LATER PREHISTORY OF THE SHAHRIZOR PLAIN, KURDISTAN REGION OF IRAQ: FURTHER INVESTIGATIONS AT GURGA CHIYA AND TEPE MARANI
Authors: Carter Robert , Wengrow David , Saber Saber Ahmed , Hamarashi Sami Jamil , Shepperson Mary , Roberts Kirk , Lewis Michael P. , Marsh Anke , Carretero Lara Gonzalez , Sosnowska Hanna , D'Amico Alexander , Sagan Wiktoria , Lockyear Kris
Published: November 2020

The Shahrizor Prehistory Project has targeted prehistoric levels of the Late Ubaid and Late Chalcolithic 4 (LC4; Late Middle Uruk) periods at Gurga Chiya (Shahrizor, Kurdistan region of northern Iraq), along with the Halaf period at the adjacent site of Tepe Marani. Excavations at the latter have produced new dietary and environmental data for the sixth millennium B.C. in the region, while at Gurga Chiya part of a burned Late Ubaid tripartite house was excavated. This has yielded a promising archaeobotanical assemblage and established a benchmark ceramic assemblage for the Shahrizor Plain, which is closely comparable to material known from Tell Madhhur in the Hamrin valley. The related series of radiocarbon dates gives significant new insights into the divergent timing of the Late Ubaid and early LC in northern and southern Mesopotamia. In the following occupation horizon, a ceramic assemblage closely aligned to the southern Middle Uruk indicates convergence of material culture with central and southern Iraq as early as the LC4 period. Combined with data for the appearance of Early Uruk elements at sites in the adjacent Qara Dagh region, this hints at long-term co-development of material culture during the fourth millennium B.C. in southeastern Iraqi Kurdistan and central and southern Iraq, potentially questioning the model of expansion or colonialism from the south.
Entrepreneurial orientation and the interaction of top management team background characteristics
Authors: Boling J. Ruben , Vecchiarini Mariangela
Published: November 2020

The current study draws on the upper echelons theory to examine the nature of the relationship between top management team (TMT) tenure and a firm's level of entrepreneurial orientation (EO). We find evidence of an inverted-U relationship between TMT tenure and EO using data from firms across three industries with varied industry dynamics. We further introduce a contingency element by demonstrating that TMT industry background heterogeneity moderates the relationship between TMT tenure and EO, where the inverted U-shaped relationship will be more pronounced when the heterogeneity is low and will flatten when the heterogeneity is high. The findings demonstrate the complexity CEOs and governing bodies face while shaping a diverse TMT that can affect EO.
Free, easy and effective: how young adults used 8 weeks of mailed nicotine patches and to what effect
Authors: Lawrance Kelli-an , Kirkwood Amanda , Travis Heather , Selby Peter
Published: November 2020

Introduction

Research shows the mass distribution of free nicotine replacement therapy (NRT) is a high-impact, population-level strategy for smoking cessation; but underrepresentation of younger, and/or lighter, smokers challenges generalisability of findings to young adult smokers.

Aims

This naturalistic study examined how and with what effect young adult smokers used free nicotine patches provided through a mass mailout programme.

Methods

In total, 5,025 eligible 18–29 year-old smokers who accessed an online ordering platform received self-help materials and an 8-week course of patches matched to their consumption level (<10 cigarettes per day (cpd); ≥10 cpd). No other behavioural support occurred. Whether participants used patches correctly and achieved 30-day continuous abstinence at 6-month follow-up were assessed.

Results

Among 694 participants with complete data: 89% used some patches; 8% used the patches correctly for 8 weeks; 31.0% (95% confidence interval (CI) = 27.6, 34.7) achieved abstinence. Adjusted logistic regression analysis showed the highest odds of abstinence was associated with the correct use of patches (odds ratio = 2.8, 95% CI = 1.5, 5.1).

Conclusions

Mass distribution of free patches may be an effective public health measure for supporting younger, lighter smokers to attempt cessation, reduce consumption, or achieve abstinence. Emphasising why and how to use NRT for the entire treatment course may enhance outcomes.
Slimy worms or sticky kids
Authors: Ksiazkiewicz Aleksander , Friesen Amanda
Published: November 2020

Abstract

Disgust is derived from evolutionary processes to avoid pathogen contamination. Theories of gender differences in pathogen disgust utilize both evolutionary psychological and sociocultural perspectives. Drawing on research that suggests that masculine and feminine gender identities are somewhat orthogonal, we examine how gender identity intersects with pathogen disgust. In addition, building on evolutionary psychological and sociocultural accounts of how caregiving and parental investment affect pathogen disgust, we present a new measure of caregiving disgust and compare its properties across gender, parental status, and political ideology with those of a conventional pathogen disgust measure. This registered report finds that how masculinity and femininity affect disgust varies by gender, disgust domain, and their intersection; that parental status effects vary by disgust domain but not gender; that reframing disgust in terms of caregiving eliminates the gender gap in disgust; and that the caregiving frame unexpectedly strengthens the relationship between disgust and political ideology.
What's (not) in a leather pouch? Tracing Islamic amulets in Asante, Ghana
Authors: Pontzen Benedikt
Published: November 2020

Islamic charms and amulets (lāyā) are simultaneously fairly common, highly valued and ardently contested items among Muslims in Asante. Tracing their history and the relations in which Muslims in Asante manufacture, make sense of and debate them, this article places such amulets within relations and delineates the discourses surrounding them. For those who manufacture and request them, these amulets are part not only of the Islamic tradition but of the divine, which permeates them. For their critics, these are un-Islamic idols that contravene the religion of Islam as they ‘keep people away from God’. Such amulets and their usage – or their non-usage – are therefore central to people relating to the divine, and as amulets thus take part in various (re)makings of Islam, they matter and are part of larger processes that knit several elements together. If one considers such amulets as genuine sources, they provide a lot of information not only about how people conceive of, debate and live Islam, but of how Islamic lifeworlds come into being and of the various entities that participate in these processes.
Accelerated fragility: exploring the supply–demand nexus in health facilities in rural Burkina Faso
Authors: Samuelsen Helle
Published: November 2020

In Burkina Faso, political turmoil, escalating insecurity and a looming pandemic challenge the population's trust in the state. This article contributes to the debates about state–citizen relationships in fragile countries by connecting local health-seeking practices with the global trends of datafication and a strong focus on the fight against malaria in this part of Africa. Drawing on long-term research engagement in Burkina Faso, I examine the health-seeking practices of rural citizens and look into diagnostic routines and reporting in two rural dispensaries. I show how the routinization of diagnostic procedures combined with a strong national and global political focus on the fight against malaria create what I term a ‘supply–demand nexus’ in which rural citizens selectively ask for the health services that they know the system can supply. I argue that the routinized diagnostic practices that mainly focus on malaria serve as a ‘technology of invisibility’ by not capturing other important diseases among the rural population. Finally, I ask whether the limited healthcare services in the current context of political insecurity, instability and a global pandemic spur a process of further fragilization of the social contract between rural citizens and the state.
Hybrid simulation of NBI fast-ion losses due to the Alfvén eigenmode bursts in the Large Helical Device and the comparison with the fast-ion loss detector measurements
Authors: Seki R. , Todo Y. , Suzuki Y. , Ogawa K. , Isobe M. , Spong D. A. , Osakabe M.
Published: November 2020

The multiphase simulations are conducted with the kinetic-magnetohydrodynamics hybrid code MEGA to investigate the spatial and the velocity distributions of lost fast ions due to the Alfvén eigenmode (AE) bursts in the Large Helical Device plasmas. It is found that fast ions are lost along the divertor region with helical symmetry both before and during the AE burst except for the promptly lost particles. On the other hand, several peaks are present in the spatial distribution of lost fast ions along the divertor region. These peaks along the divertor region can be attributed to the deviation of the fast-ion orbits from the magnetic surfaces due to the grad-B and the curvature drifts. For comparison with the velocity distribution of lost fast ions measured by the fast-ion loss detector (FILD), the ‘numerical FILD’ which solves the Newton–Lorentz equation is constructed in the MEGA code. The velocity distribution of lost fast ions detected by the numerical FILD during AE burst is in good qualitative agreement with the experimental FILD measurements. During the AE burst, fast ions with high energy (100–180 keV) are detected by the numerical FILD, while co-going fast ions lost to the divertor region are the particles with energy lower than 50 keV.
Comparative cleaning behaviour of Pederson's cleaner shrimp (Ancylomenes pedersoni) between geographically close yet ecologically dissimilar coral reef habitats
Authors: Romain Joseph J. , Exton Dan A. , Smith David J. , Rose Amelia , Vondriska Clayton , Titus Benjamin M.
Published: November 2020

Cleaning mutualisms are important interactions on coral reefs. Intraspecific variation in cleaning rate and behaviour occurs geographically and is often attributed to local processes. However, our understanding of fine-scale variation is limited, but would allow us to control for geography and region-specific behavioural patterns. Here, we compare the cleaning activity of Pederson's cleaner shrimp (Ancylomenes pedersoni) on two neighbouring, yet ecologically dissimilar, reef systems in Honduras: Banco Capiro, an offshore bank close to significant land runoff with high coral cover but a depleted fish population, and an oligotrophic fringing reef around the island of Utila, with lower coral cover but high fish abundance and diversity. The proportion of realized to potential fish clientele was <60% at both sites, and the composition of clientele was neither reflective of the demographics of the resident assemblages at each site nor similar between sites. Parrotfishes represented 13–15% of total fish abundance at both sites yet accounted for >50% (Banco Capiro) and 10% (Utila) of all cleans. Conversely, the schoolmaster snapper (Lutjanus apodus) represented ~1% of total fish abundance at both sites yet accounted for 40% (Utila) and 1% (Banco Capiro) of all cleans. After standardizing our cleaning rate data by clientele abundance, we find that clientele at Banco Capiro engage in over four times as many cleaning encounters per hour with A. pedersoni than at Utila. Our study highlights the variable nature of coral reef cleaning interactions and the need to better understand the ecological and environmental drivers of this biogeographic variation.
Aberrant functional connectivity of neural circuits associated with thought-action fusion in patients with obsessive–compulsive disorder
Authors: Lee Sang Won , Song Huijin , Jang Tae Yang , Cha Hyunsil , Kim Eunji , Chang Yongmin , Lee Seung Jae
Published: November 2020

Background

Cognitive theories of obsessive–compulsive disorder (OCD) stress the importance of dysfunctional beliefs in the development and maintenance of the disorder. However, a neurobiological understanding of these cognitive models, including thought-action fusion (TAF), is surprisingly lacking. Thus, this functional magnetic resonance imaging study aimed to investigate whether altered functional connectivity (FC) is associated with the TAF paradigm in OCD patients.

Methods

Forty-one OCD patients and 47 healthy controls (HCs) participated in a functional magnetic resonance imaging study using a TAF task, in which they were asked to read the name of a close or a neutral person in association with positive and negative statements.

Results

The conventional TAF condition (negative statements/close person) induced significant FC between the regions of interest (ROIs) identified using multivoxel pattern analysis and the visual association areas, default mode network subregions, affective processing, and several subcortical regions in both groups. Notably, sparser FC was observed in OCD patients. Further analysis confined to the cortico-striato-thalamo-cortical (CSTC) and affective networks demonstrated that OCD patients exhibited reduced ROI FC with affective regions and greater ROI FC with CSTC components in the TAF condition compared to HCs. Within the OCD patients, middle cingulate cortex–insula FC was correlated with TAF and responsibility scores.

Conclusions

Our TAF paradigm revealed altered context-dependent engagement of the CSTC and affective networks in OCD patients. These findings suggest that the neurobiology of cognitive models corresponds to current neuroanatomical models of OCD. Further, they elucidate the underlying neurobiological mechanisms of OCD at the circuit-based level.
Judicial diplomacy: International courts and legitimation
Authors: Squatrito Theresa
Published: November 2020

Observers of international courts (ICs) note that several ICs carry out a broad range of non-judicial activities, ranging from legal training workshops and public seminars to visits with public officials. Despite the growing prominence of these activities, they have received little attention from scholars. Seeking to fill this gap, this article examines these activities as a form of ‘judicial diplomacy’, asking how and why ICs employ judicial diplomacy. The article argues that ICs use judicial diplomacy as a means of legitimation. They seek to boost institutional legitimacy through their judicial diplomacy by targeting the public and communicating norm-referential narratives about their processes and outcomes. This argument bears out in case studies on the judicial diplomacy of the African Court of Human and Peoples’ Rights and the Caribbean Court of Justice. Both courts are shown to have judicial diplomacy that is public-oriented and people-centred. This argument has important implications for literature on international courts and the legitimacy of international institutions.
Value assessment of antimicrobials and the implications for development, access, and funding of effective treatments: Australian stakeholder perspective
Authors: Hillock Nadine T. , Merlin Tracy L. , Karnon Jonathan , Turnidge John , Eliott Jaklin
Published: November 2020

Background

The frameworks used by Health Technology Assessment (HTA) agencies for value assessment of medicines aim to optimize healthcare resource allocation. However, they may not be effective at capturing the value of antimicrobial drugs.

Objectives

To analyze stakeholder perceptions regarding how antimicrobials are assessed for value for reimbursement purposes and how the Australian HTA framework accommodates the unique attributes of antimicrobials in cost-effectiveness evaluation.

Methods

Eighteen individuals representing the pharmaceutical industry or policy-makers were interviewed. Interviews were transcribed verbatim, coded, and thematically analyzed.

Results

Key emergent themes were that reimbursement decision-making should consider the antibiotic spectrum when assessing value, risk of shortages, the impact of procurement processes on low-priced comparators, and the need for methodological transparency when antimicrobials are incorporated into the economic evaluation of other treatments.

Conclusions

Participants agreed that the current HTA framework for antimicrobial value assessment is inadequate to properly inform funding decisions, as the contemporary definition of cost-effectiveness fails to explicitly incorporate the risk of future resistance. Policy-makers were uncertain about how to incorporate future resistance into economic evaluations without a systematic method to capture costs avoided due to good stewardship. Lacking financial reward for the benefits of narrower-spectrum antimicrobials, companies will likely focus on developing broad-spectrum agents with wider potential use. The perceived risks of shortages have influenced the funding of generic antimicrobials in Australia, with policy-makers suggesting a willingness to pay more for assured supply. Although antibiotics often underpin the effectiveness of other medicines, it is unclear how this is incorporated into economic models.
From exceptional to normal: changes in the structure of US banking since 1920
Authors: Sylla Richard
Published: November 2020

A century ago the US commercial banking system was exceptional in two ways. It was by good measure the largest commercial banking system of any country. And it was different from the commercial banking systems of other leading countries in having tens of thousands of independent banks with very few branches rather than the more typical pattern of a far smaller number of banks with many branches. Today, a century later, the US system is more normal than exceptional, dominated by a small number of very large banks with extensive branch systems. This article describes the US banking-structure transition from exceptional to normal. It closes with an interesting contrast of US and European banking developments.
Analysis of factors associated with prolonged post-operative course after surgical repair of aortic coarctation
Authors: Kaipa Santosh , Yabrodi Mouhammad , Benneyworth Brian D. , Ebenroth Eric S. , Mastropietro Christopher W.
Published: November 2020

Objective:

We sought to describe patient characteristics associated with prolonged post-operative length of stay in a contemporary cohort of infants who underwent isolated repair of aortic coarctation.

Methods:

We reviewed patients less than 1 year of age who underwent isolated repair of aortic coarctation at our institution from 2009 to 2016. Prolonged post-operative length of stay was defined as length of stay within the upper tertile for the cohort. Bivariate and multi-variable analyses were performed to determine independent risk factors for prolonged length of stay.

Results:

We reviewed 95 consecutive patients who underwent isolated repair of aortic coarctation, of whom 71 were neonates at the time of diagnosis. The median post-operative length of stay was 6.5 days. The upper tertile for post-operative length of stay was greater than 10 days; 32 patients within this tertile and 1 patient who died at 8.5 days after surgery were analysed as having prolonged post-operative length of stay. In a multi-variable analysis, pre-maturity (odds ratio: 3.5, 95% confidence interval: 1.2, 10.7), genetic anomalies (odds ratio: 4.7, 95% confidence interval: 1.2, 18), absence of pre-operative oral feeding (odds ratio: 7.4, 95% confidence interval: 2.4, 22.3), and 12-hour vasoactive-ventilation-renal score greater than 25 (odds ratio: 7.4, 95% confidence interval: 1.9, 29) were independently associated with prolonged length of stay.

Conclusions:

In neonates and infants who underwent isolated repair of aortic coarctation, pre-maturity, genetic anomalies, lack of pre-operative oral feedings, and 12-hour vasoactive-ventilation-renal score more than 25 were independent risk factors for prolonged post-operative length of stay. Further study on the relationship between pre-operative oral feedings and post-operative length of stay should be pursued.
Prehospital Tourniquets in Civilians: A Systematic Review
Authors: Eilertsen Kenneth A. , Winberg Morten , Jeppesen Elisabeth , Hval Gyri , Wisborg Torben
Published: November 2020

Objectives:

Terrorist attacks and civilian mass-casualty events are frequent, and some countries have implemented tourniquet use for uncontrollable extremity bleeding in civilian settings. The aim of this study was to summarize current knowledge on the use of prehospital tourniquets to assess whether their use increases the survival rate in civilian patients with life-threatening hemorrhages from the extremities.

Design:

Systematic literature review in Medline (Ovid), Embase (Ovid), Cochrane Library, and Epistemonikos was performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Guidelines. The search was performed in January 2019.

Setting:

All types of studies that examined use of tourniquets in a prehospital setting published after January 1, 2000 were included.

Primary/Secondary Outcomes:

The primary outcome was mortality with and without tourniquet, while adverse effects of tourniquet use were secondary outcomes.

Results:

Among 3,460 screened records, 55 studies were identified as relevant. The studies were highly heterogeneous with low quality of evidence. Most studies reported increased survival in the tourniquet group, but few had relevant comparators, and the survival benefit was difficult to estimate. Most studies reported a reduced need for blood transfusion, with few and mainly transient adverse effects from tourniquet use.

Conclusion:

Despite relatively low evidence, the studies consistently suggested that the use of commercial tourniquets in a civilian setting to control life-threatening extremity hemorrhage seemed to be associated with improved survival, reduced need for blood transfusion, and few and transient adverse effects.
Factors Associated with Survival in Adult Trauma Patients Transported to US Trauma Centers by Police
Authors: Colnaric Jure M. , Bachir Rana H. , El Sayed Mazen J.
Published: November 2020

Introduction:

Police units often reach the trauma scene before Emergency Medical Services (EMS). Initiatives aiming at delivering early basic trauma care by non-medical providers including police personnel are on the rise. This study describes characteristics of trauma patients transported by police to US hospitals and identifies factors associated with survival in this patient population.

Methods:

Using the 2015 National Trauma Data Bank (NTDB), an observational study was conducted of adult trauma patients who were transported by police. After describing the study population, the factors associated with survival to hospital discharge were evaluated using a multivariate analysis.

Results:

A total of 2,394 patients were included in the study. Patients had a median age of 34.0 years (interquartile range [IQR]: 25-48) and most were males (84.5%). Blunt trauma mechanism (59.4%) was more common than penetrating trauma (29.4%). Factors associated with improved survival included: comorbidity (odds ratio [OR] = 2.92; 95% CI, 1.33-6.40); use of drugs (OR = 2.91; 95% CI, 1.07-7.92); cut/pierce (OR = 11.07; 95% CI, 2.10-58.43); motor vehicle traffic (MVT) mechanism (OR = 6.56; 95% CI, 1.60-26.98); trauma resulting in fractures (OR = 3.03; 95% CI, 1.38-6.64); and private/commercial insurance (OR = 3.41; 95% CI, 1.10-10.55).

Conclusion:

In this study population, a relatively high survival rate was noted (93.5%). Police transport of patients with blunt trauma was unexpectedly more common. Factors associated with survival to hospital discharge were identified. These factors can be used to implement more standardized and protocol-driven risk stratification tools of trauma patients on scene to improve police involvement in trauma patient transport.
Positional spelling redistribution: word-initial / and / in Early Modern English (1500–1700)
Authors: CONDORELLI MARCO
Published: November 2020

The alternations in / and / are among the most well-known and commented-upon changes in Early Modern English spellings, yet little has been said about the potential factors underlying their standardisation, and whether and how the two alternant pairs could be linked together. The reason behind this knowledge gap may be found in the absence of a large-scale, quantitative investigation of these spellings, and consequently, the impossibility of commenting upon the relationship between patterns of chronological development and potential causes of change. This article focuses on the standardisation of word-initial / and / between 1500 and 1700 in printed English, and uses a quantitative model for the analysis of patterns of diachronic development in the two alternant pairs, across a range of texts from a sampled version ofEarly English Books Online. The results describe a rather abrupt, synchronised change in the redistribution of word-initial / and / between the 1620s and the 1640s. The discussion argues for a close connection between the diachronic developments in word-initial / and /, and pragmatic factors that affected the Early Modern English printing industry.
Intra‐Annual and Interannual Dynamics of Evaporation Over Western Lake Erie
Authors: Shao Changliang , Chen Jiquan , Chu Housen , Stepien Carol A. , Ouyang Zutao
Published: November 2020

Evaporation (E) is a critical component of the water and energy budget in lake systems yet is challenging to quantify directly and continuously. We examined the magnitude and changes of E and its drivers over Lake Erie—the shallowest and most southern lake of the Laurentian Great Lakes. We deployed two eddy‐covariance tower sites in the western Lake Erie Basin—one located nearshore (CB) and one offshore (LI)—from September 2011 through May 2016. Monthly E varied from 5 to 120 mm, with maximum E occurring in August–October. The annual E was 635 ± 42 (±SD) mm at CB and 604 ± 32 mm at LI. Mean winter (October–March) E was 189 ± 61 mm at CB and 178 ± 25 mm at LI, accounting for 29.8% and 29.4% of annual E. Mean daily E was 1.8 mm during the coldest month (January) and 7.4 mm in the warmest month (July). Monthly E exhibited a strong positive linear relationship to the product of wind speed and vapor pressure deficit. Pronounced seasonal patterns in surface energy fluxes were observed with a 2‐month lag in E from Rn, due to the lake's heat storage. This lag was shorter than reports regarding other Great Lakes. Difference in E between the offshore and nearshore sites reflected within‐lake spatial heterogeneity, likely attributable to climatic and bathymetric differences between them. These findings suggest that predictive models need to consider lake‐specific heat storage and spatial heterogeneity in order to accurately simulate lake E and its seasonal dynamics.
Quantifying Long‐Term Seasonal and Regional Impacts of North American Fire Activity on Continental Boundary Layer Aerosols and Cloud Condensation Nuclei
Authors: Logan Timothy , Dong Xiquan , Xi Baike , Zheng Xiaojian , Wang Yuan , Wu Peng , Marlow Eleanor , Maddux James
Published: November 2020

An intimate knowledge of aerosol transport is essential in reducing the uncertainty of the impacts of aerosols on cloud development. Data sets from the U.S. Department of Energy (DOE) Atmospheric Radiation Measurement platform in the Southern Great Plains region (ARM‐SGP) and the National Aeronautics and Space Administration (NASA) Modern‐Era Retrospective Analysis for Research and Applications, version 2 (MERRA‐2), showed seasonal increases in aerosol loading and total carbon concentration during the spring and summer months (2008–2016) which was attributed to fire activity and smoke transport within North America. The monthly mean MERRA‐2 surface carbonaceous aerosol mass concentration and ARM‐SGP total carbon products were strongly correlated (R = 0.82, p < 0.01) along with a moderate correlation with the ARM‐SGP cloud condensation nuclei (NCCN) product (0.5, p ~ 0.1). The monthly mean ARM‐SGP total carbon and NCCN products were strongly correlated (0.7, p ~ 0.01). An additional product denoting fire number and coverage taken from the National Interagency Fire Center (NIFC) showed a moderate correlation with the MERRA‐2 carbonaceous product (0.45, p < 0.01) during the 1981–2016 warm season months (March–September). With respect to meteorological conditions, the correlation between the NIFC fire product and MERRA‐2 850‐hPa isobaric height anomalies was lower (0.26, p ~ 0.13) due to the variability in the frequency, intensity, and number of fires in North America. An observed increase in the isobaric height anomaly during the past decade may lead to frequent synoptic ridging and drier conditions with more fires, thereby potentially impacting cloud/precipitation processes and decreasing air quality.
Mass and Number Size Distributions of rBC in Snow and Firn Samples From Pine Island Glacier, West Antarctica
Authors: Marquetto Luciano , Kaspari Susan , Simões Jefferson Cardia
Published: November 2020

An extended‐range Single Particle Soot Photometer (SP2) coupled to a Marin‐5 nebulizer was used to measure the refractory black carbon (rBC) mass and number size distributions in 1,004 samples from a West Antarctica snow/firn core. The SP2 was calibrated using Aquadag and a Centrifugal Particle Mass Analyzer for BC particles ranging from 0.5 to 800 fg. Our results indicate a significant contribution of rare, large particles of mass‐equivalent diameter (DBC) > 500 nm to the total rBC mass (36%), while small particles (DBC < 100 nm) are abundant but contribute <8% to total rBC mass. We observed a primary mass median diameter of 162 ± 40 nm, smaller than reported for snow in other regions of the globe but similar to East Antarctica rBC size distributions. In addition, we observed other modes at 673, 1,040, and >1,810 nm (uncontained mode). We compared two sets of samples from different seasons (wet vs. dry) and observed that dry season concentrations are 3.4 and 2 times that of the wet season in the ranges of 80 nm < DBC < 500 nm (small particles) and 500 nm < DBC < 2,000 nm (large particles), respectively, while number of particles in the dry season is 3.5 and 2 times that of the wet season for the same size ranges. Millimeter thick melt layers have been observed in some samples, although they did not change the observed median diameter. This study provides the first detailed rBC mass and number size distribution from West Antarctica.
Traversing the High Sierra on the People’s Paths
Authors: Morton Mary
Published: November 2020

Living in Geologic Time: Backpacking through the past, present, and future of fire on the John Muir Trail.
Carbon Dioxide and Methane Flux in a Dynamic Arctic Tundra Landscape: Decadal‐Scale Impacts of Ice Wedge Degradation and Stabilization
Authors: Wickland K. P. , Jorgenson M. T. , Koch J. C. , Kanevskiy M. , Striegl R. G.
Published: November 2020

Ice wedge degradation is a widespread occurrence across the circumpolar Arctic causing extreme spatial heterogeneity in water distribution, vegetation, and energy balance across landscapes. These heterogeneities influence carbon dioxide (CO2) and methane (CH4) fluxes, yet there is little understanding of how they effect change in landscape‐level carbon (C) gas flux over time. We measured CO2 and CH4 fluxes in an area undergoing ice wedge degradation near Prudhoe Bay, Alaska, and combined with repeat imagery analysis to estimate seasonal landscape‐level C flux response to geomorphic change. Net CO2 and CH4 emissions changed by −25% and +42%, respectively, resulting in a 14% increase in seasonal CO2‐C equivalent emissions over 69 years as ice wedge degradation formed water‐filled troughs. The dynamic ice wedge degradation/stabilization process can cause significant changes in CO2 and CH4 fluxes over time, and the integration of this process is important to forecasting landscape‐level C fluxes in permafrost regions abundant in ice wedges.
Response of the Southern Ocean Overturning Circulation to Extreme Southern Annular Mode Conditions
Authors: Stewart K. D. , Hogg A.McC. , England M. H. , Waugh D. W.
Published: November 2020

The positive trend of the Southern Annular Mode (SAM) will impact the Southern Ocean's role in Earth's climate; however, the details of the Southern Ocean's response remain uncertain. We introduce a methodology to examine the influence of SAM on the Southern Ocean and apply this method to a global ocean‐sea ice model run at three resolutions (1°, (1/4)°, and (1/10)°). Our methodology drives perturbation simulations with realistic atmospheric forcing of extreme SAM conditions. The thermal response agrees with previous studies; positive SAM perturbations warm the upper ocean north of the wind speed maximum and cool it to the south, with the opposite response for negative SAM. The overturning circulation exhibits a rapid response that increases/decreases for positive/negative SAM perturbations and is insensitive to model resolution. The longer‐term adjustment of the overturning circulation, however, depends on the representation of eddies, and is faster at higher resolutions.
Probing the Ecology and Climate of the Eocene Southern Ocean With Sand Tiger Sharks Striatolamia macrota
Authors: Kim Sora L. , Zeichner Sarah S. , Colman Albert S. , Scher Howie D. , Kriwet Jürgen , Mörs Thomas , Huber Matthew
Published: November 2020

Many explanations for Eocene climate change focus on the Southern Ocean—where tectonics influenced oceanic gateways, ocean circulation reduced heat transport, and greenhouse gas declines prompted glaciation. To date, few studies focus on marine vertebrates at high latitudes to discern paleoecological and paleoenvironmental impacts of this climate transition. The Tertiary Eocene La Meseta (TELM) Formation has a rich fossil assemblage to characterize these impacts; Striatolamia macrota, an extinct (†) sand tiger shark, is abundant throughout the La Meseta Formation. Body size is often tracked to characterize and integrate across multiple ecological dimensions. †S. macrota body size distributions indicate limited changes during TELMs 2–5 based on anterior tooth crown height (n = 450, mean = 19.6 ± 6.4 mm). Similarly, environmental conditions remained stable through this period based on δ18OPO4 values from tooth enameloid (n = 42; 21.5 ± 1.6‰), which corresponds to a mean temperature of 22.0 ± 4.0°C. Our preliminary εNd (n = 4) results indicate an early Drake Passage opening with Pacific inputs during TELM 2–3 (45–43 Ma) based on single unit variation with an overall radiogenic trend. Two possible hypotheses to explain these observations are (1) †S. macrota modified its migration behavior to ameliorate environmental changes related to the Drake Passage opening, or (2) the local climate change was small and gateway opening had little impact. While we cannot rule out an ecological explanation, a comparison with climate model results suggests that increased CO2 produces warm conditions that also parsimoniously explain the observations.
Parp3 promotes astrocytic differentiation through a tight regulation of Nox4-induced ROS and mTorc2 activation
Authors: Rodriguez-Vargas José-Manuel , Martin-Hernandez Kathline , Wang Wei , Kunath Nicolas , Suganthan Rajikala , Amé Jean-Christophe , Oliver F. Javier , Ye Jing , Bjørås Magnar , Dantzer Françoise
Published: November 2020

Parp3 is a member of the Poly(ADP-ribose) polymerase (Parp) family that has been characterized for its functions in strand break repair, chromosomal rearrangements, mitotic segregation and tumor aggressiveness. Yet its physiological implications remain unknown. Here we report a central function of Parp3 in the regulation of redox homeostasis in continuous neurogenesis in mice. We show that the absence of Parp3 provokes Nox4-induced oxidative stress and defective mTorc2 activation leading to inefficient differentiation of post-natal neural stem/progenitor cells to astrocytes. The accumulation of ROS contributes to the decreased activity of mTorc2 as a result of an oxidation-induced and Fbxw7-mediated ubiquitination and degradation of Rictor. In vivo, mTorc2 signaling is compromised in the striatum of naïve post-natalParp3-deficient mice and 6 h after acute hypoxia-ischemia. These findings reveal a physiological function of Parp3 in the tight regulation of striatal oxidative stress and mTorc2 during astrocytic differentiation and in the acute phase of hypoxia-ischemia.
mTORC1 activation in lung mesenchyme drives sex- and age-dependent pulmonary structure and function decline
Authors: Obraztsova Kseniya , Basil Maria C. , Rue Ryan , Sivakumar Aravind , Lin Susan M. , Mukhitov Alexander R. , Gritsiuta Andrei I. , Evans Jilly F. , Kopp Meghan , Katzen Jeremy , Robichaud Annette , Atochina-Vasserman Elena N. , Li Shanru , Carl Justine , Babu Apoorva , Morley Michael P. , Cantu Edward , Beers Michael F. , Frank David B. , Morrisey Edward E. , Krymskaya Vera P.
Published: November 2020

Lymphangioleiomyomatosis (LAM) is a rare fatal cystic lung disease due to bi-allelic inactivating mutations in tuberous sclerosis complex (TSC1/TSC2) genes coding for suppressors of the mechanistic target of rapamycin complex 1 (mTORC1). The origin of LAM cells is still unknown. Here, we profile a LAM lung compared to an age- and sex-matched healthy control lung as a hypothesis-generating approach to identify cell subtypes that are specific to LAM. Our single-cell RNA sequencing (scRNA-seq) analysis reveals novel mesenchymal and transitional alveolar epithelial states unique to LAM lung. This analysis identifies a mesenchymal cell hub coordinating the LAM disease phenotype. Mesenchymal-restricted deletion of Tsc2 in the mouse lung produces a mTORC1-driven pulmonary phenotype, with a progressive disruption of alveolar structure, a decline in pulmonary function, increase of rapamycin-sensitive expression of WNT ligands, and profound female-specific changes in mesenchymal and epithelial lung cell gene expression. Genetic inactivation of WNT signaling reverses age-dependent changes of mTORC1-driven lung phenotype, but WNT activation alone in lung mesenchyme is not sufficient for the development of mouse LAM-like phenotype. The alterations in gene expression are driven by distinctive crosstalk between mesenchymal and epithelial subsets of cells observed in mesenchymal Tsc2-deficient lungs. This study identifies sex- and age-specific gene changes in the mTORC1-activated lung mesenchyme and establishes the importance of the WNT signaling pathway in the mTORC1-driven lung phenotype.