bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring the Social Drivers of Health During a Pandemic: Leveraging Knowledge Graphs and Population Trends in COVID-19
Authors: Bettencourt-Silva Joao H. , Mulligan Natasha , Jochim Charles , Yadav Nagesh , Sedlazek Walter , Lopez Vanessa , Gleize Martin
Published: November 2020

Social determinants of health (SDoH) are the factors which lie outside of the traditional health system, such as employment or access to nutritious foods, that influence health outcomes. Some efforts have focused on identifying vulnerable populations during the COVID-19 pandemic, however, both the short- and long-term social impacts of the pandemic on individuals and populations are not well understood. This paper presents a pipeline to discover health outcomes and related social factors based on trending SDoH at population-level using Google Trends. A knowledge graph was built from a corpus of research literature (PubMed) and the social determinants that trended high at the start of the pandemic were examined. This paper reports on related social and health concepts which may be impacted by the COVID-19 outbreak and may be important to monitor as the pandemic evolves. The proposed pipeline should have wider applicability in surfacing related social or clinical characteristics of interest, outbreak surveillance, or to mine relations between social and health concepts that can, in turn, help inform and support citizen-centred services.
Implementing an Urban Public Health Observatory for (Near) Real-Time Surveillance for the COVID-19 Pandemic
Authors: Brakefield Whitney S. , Ammar Nariman , Olusanya Olufunto , Ozdenerol Esra , Thomas Fridtjof , Stewart Altha J. , Johnson Karen C. , Davis Robert L. , Schwartz David L. , Shaban-Nejad Arash
Published: November 2020

The COVID-19 pandemic is broadly undercutting global health and economies, while disproportionally impacting socially disadvantaged populations. An impactful pandemic surveillance solution must draw from multi-dimensional integration of social determinants of health (SDoH) to contextually inform traditional epidemiological factors. In this article, we describe an Urban Public Health Observatory (UPHO) model which we have put into action in a mid-sized U.S. metropolitan region to provide near real-time analysis and dashboarding of ongoing COVID-19 conditions. Our goal is to illuminate associations between SDoH factors and downstream pandemic health outcomes to inform specific policy decisions and public health planning.
Usability of Remote Assessment of Exercise Capacity for Pulmonary Telerehabilitation Program
Authors: Finkelstein Joseph , Jeong In cheol , Doerstling Mackenzie , Shen Yichao , Wei Chenhao , Karpatkin Herbert
Published: November 2020

Pulmonary rehabilitation [PR] has been successfully carried out via telemedicine however initial patient assessment has been traditionally conducted in PR centers. The first step in PR is assessment of patient’s exercise capacity which allows individualized prescription of safe and effective exercise program. With COVID-19 pandemics assessment of patients in PR centers has been limited resulting in significant reduction of patients undergoing life-saving PR. The goal of this pilot study was to introduce approaches for remote assessment of exercise capacity using videoconferencing platforms and provide initial usability assessment of this approach by conducing cognitive walkthrough testing. We developed a remote assessment system that supports comprehensive physical therapy assessment necessary for prescription of a personalized exercise program tailored to individual fitness level and limitations in gait and balance of the patient under evaluation. Usability was assessed by conducting cognitive walkthrough and system usability surveys. The usability inspection of the remote exercise assessment demonstrated overall high acceptance by all study participants. Our next steps in developing user-centered interface should include usability evaluation in different subgroups of patients with varying socio-economic background, different age groups, computer skills, literacy and numeracy.
Technology Supporting Nursing at Homecare – Seems to Be Lacking
Authors: Kivekäs Eija , Mikkonen Santtu , Koponen Samuli , Saranto Kaija
Published: November 2020

The use of welfare technologies in the home setting has drawn increased attention in healthcare. From a historical perspective, medical technologies were designed for hospital settings. Digitalization and internet of things have changed the structure of our society. The aim of this paper is to describe the factors that determine a user’s intent to adopt new welfare technologies in the context of homecare. The phenomenon was being examined by the unified theory of acceptance and use of technology. This study was to show that performance expectancy, effort expectancy, and facilitating conditions are significant factors in determining a user’s intention to use new welfare technologies. While, the use of welfare technologies was rare in homecare.
Reuse of Clinical COVID-19 Patient Data: Pre-Processing for Future Classification
Authors: Lazarova Elena , Mora Sara , Di Biagio Antonio , Vena Antonio , Giacomini Mauro
Published: November 2020

One of the most important challenges in the scenario of COVID-19 is to design and develop decision support systems that can help medical staff to identify a cohort of patients that is more likely to have worse clinical evolution. To achieve this objective it is necessary to work on collected data, pre-process them in order to obtain a consistent dataset and then extract the most relevant features with advanced statistical methods like principal component analysis. As preliminary results of this research, very influential features that emerged are the presence of cardiac and liver illnesses and the levels of some inflammatory parameters at the moment of diagnosis.
Patient-Centered Development of a Digital Care Pathway for Arrhythmia Patients
Authors: Liljamo Pia , Säilynoja Hanna , Tuomikoski Kirsi , Henner Anja , Koivunen Kirsi
Published: November 2020

Citizens are ready and willing to use various kinds of e-health services and Web-based portals. The purpose of this study was to describe the experiences of patients who underwent an arrhythmia procedure of the guidance they received as well as their needs and expectations for a future digital care path. The goal for the future is to utilize the results in other patient-centered digital service development activities. The research material was collected in a two-part thematic interview with patients who underwent an electrophysiology examination and supraventricular tachycardia catheter ablation procedure (n=7) or ablation treatment for atrial fibrillation (n=4). The preliminary digital care path was modified based on the results. The arrhythmia patient’s digital care path was tested in a workshop using a test group consisting of patients (n=3) and nursing staff (n=6). As a result, a digital care pathway for arrhythmia patients was completed.
Physical Activity in Cardiac Rehabilitation: Towards Citizen-Centered Digital Evidence-Based Interventions
Authors: Gutenberg Johanna , Kulnik Stefan Tino , Hussein Rada , Stütz Thomas , Niebauer Josef , Crutzen Rik
Published: November 2020

Physical activity is a vital part of cardiac rehabilitation (CR). However, heart-healthy physical activity levels in people with cardiovascular disease drop significantly after CR. This exploratory study employs qualitative and survey methods within a co-creation approach. The aim is to understand the mechanisms of healthy behavior and habit formation in order to create a novel evidence-based (post-)rehabilitation approach that employs digital means to sustain long-term physical activity levels in people with cardiovascular disease.
Eating behavior in patients with type 2 diabetes and melanocortin receptor gene polymorphism
Authors:   Bashkir State Medical University, Ufa, Russian Federation, Avzaletdinova D.Sh. , Morugova T.V. ,   Bashkir State Medical University, Ufa, Russian Federation, Sharipova L.F. ,   Bashkir State Medical University, Ufa, Russian Federation, Kochetova O.V. ,   Institute of Biochemistry and Genetics of Ufa Scientific Center of the Russian Academy  of Sciences, Ufa, Russian Federation
Published: November 2020

Aim: to analyze the associations of rs17782313 polymorphism of melanocortin type 4 receptor (MC4R) gene in patients with type 2 diabetes (T2D) in Tatar ethnic group (Republic of Bashkortostan) and to determine the types of eating disorders in T2D patients and their association with MC4R allelic variants (rs17782313).Patients and Methods: MC4R rs17782313 gene polymorphism was genotyped by polymerase chain reaction (PCR) in 190 healthy individuals (39 men and 151 women, mean age 55.3±9.8 years) and 200 patients with T2D (57 men and 143 women, mean age 59.2±9.5 years). Eating behavior was assessed using the Dutch Eating Behaviour Questionnaire (DEBQ) in 134 controls and 83 patients with T2D. All individuals belonged to the Tatar ethnic group and lived in the Republic of Bashkortostan. Statistical analysis was performed using Statistica 6.0 and SNPStats software (https://www.snpstats.net/start.htm). Odds ratio (OR) was calculated using online platform (https://www.medcalc.org/calc/odds_ratio.php).Results: higher prevalence of C/C genotype of MC4R rs17782313 gene polymorphism was revealed in T2D patients compared to the controls (6.0% vs. 2.1%, respectively, p=0.0444). T2D patients were characterized by higher “Emotional eating” scores (р<0.00001) but lower “Restrictive eating” scores (р=0.0001) and “External eating” scores (р<0.0047) compared to healthy individuals. MC4R allelic variants (rs17782313) did not demonstrate any associations with eating behavior types in either T2D patients or controls. Conclusion: C/C genotype of rs17782313 MC4R gene polymorphism is a marker of higher risk of T2D in Tatar ethnic group (OR=2.9, p=0,0444). The mechanisms by which MC4R allelic variants (rs17782313) affect T2D pathogenesis require further studies.KEYWORDS: type 2 diabetes, eating behavior, Dutch Eating Behavior Questionnaire, DEBQ, melanocortin receptor type 4 gene, emotional eating, external eating, restrictive eating, genetic susceptibility, Tatar ethnic group.FOR CITATION: Avzaletdinova D.Sh., Morugova T.V., Sharipova L.F., Kochetova O.V. Eating behavior in patients with type 2 diabetes and melanocortin receptor gene polymorphism. Russian Medical Inquiry. 2020;4(6):318–323. DOI: 10.32364/2587-6821-2020-4-6-318-323.
Impact of glycemic variability and the fear of hypoglycemia on type 1 diabetes control
Authors:   I.P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russian Federation, Volkova A.R. , Chernaya M.E. ,   I.P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russian Federation, Mozgunova V.S. ,   I.P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russian Federation, Durdyeva M.B. ,   I.P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russian Federation, Lisker A.V. ,   I.P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russian Federation
Published: November 2020

Background: currently, the level of HbA1c does not necessarily allow for the understanding of glycemic control. Considering this, glycemic variability (GV) is extensively studied in recent years. Psychological component has a significant impact on GV as the fear of hypoglycemia (FOH) and its consequences can reduce the motivation for achieving target glycemia and HbA1c as well as adherence to treatment.Aim: to assess GV in patients with type 1 diabetes with the elevated and target levels of HbA1c and to analyze the effect of FOH on diabetes control.Patients and Methods: 78 patients with type 1 diabetes who received insulin therapy (multiple daily injections or continuous subcutaneous insulin infusion) were enrolled. All patients were divided into two groups based on HbA1c levels, i.e., group 1 (patients who achieved individual HbA1c target level, n=13) and group 2 (patients who did not achieve individual HbA1c target level, n=65). HbA1c levels and GV were measured in all patients using iPRO™2 Professional CGM system (Medtronic, Ireland). In addition, FOH was evaluated using the Hypoglycemia Fear Survey II (HFS-II).Results: in group 1, time in-range was significantly higher (p=0.013) while daily GV was significantly lower (p=0.023) than in group 2. HbA1c levels, the rate of severe hypoglycemia, and diabetes duration were lower among the patients with lower levels of FOH.Conclusion: studying GV can provide better understanding of diabetes control in patients with any HbA1c level. Optimized treatment strategy using HFS-II can attenuate the effects of frequent hypoglycemia on GV and HbA1c levels and improve treatment efficacy.KEYWORDS: glycemic variability, glycated hemoglobin, diabetes, continuous glucose monitoring, hypoglycemia.FOR CITATION: Volkova A.R., Chernaya M.E., Mozgunova V.S. et al. Impact of glycemic variability and the fear of hypoglycemia on type 1 diabetes control. Russian Medical Inquiry. 2020;4(6):324–328. DOI: 10.32364/2587-6821-2020-4-6-324-328.
Male hypogonadism and type 2 diabetes: evidence-based medicine versus clinical practice
Authors:   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Demidova T.Yu. , Skuridina D.V. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation
Published: November 2020

Epidemiological studies demonstrate that low levels of serum testosterone are common in men with verified type 2 diabetes (T2D) but also account for higher risks of T2D and mortality. Current data on hypogonadism in T2D are generally similar but controversial in some aspects. Available preclinical studies suggest the mechanisms whereby low testosterone mediates the development of hyperglycemia. Many clinical data demonstrate several effects of testosterone replacement therapy, i.e., reduced fat mass, the increase in muscle mass, improved insulin resistance, the significant improvement in sexual function etc. However, some of the available randomized controlled trials fail to establish the glucose-lowering effect of this therapy. Therefore, this field is important to present systematic reviews and to identify the areas for further studies. This paper reviews currently available evidence-based medicine and routine clinical practice data on the pathogenesis and treatment for androgen deficiency in male patients with T2D.KEYWORDS: testosterone, type 2 diabetes, hypogonadism, androgen deficiency, testosterone replacement therapy.FOR CITATION: Demidova T.Yu., Skuridina D.V. Male hypogonadism and type 2 diabetes: evidence-based medicine versus clinical practice. Russian Medical Inquiry. 2020;4(6):364–371. DOI: 10.32364/2587-6821-2020-4-6-364-371.
Role of endocannabinoid system in the pathogenesis of obesity: how can we help a patient? From theory to practice
Authors:   Rostov State Medical University, Rostov-on-Don, Russian Federation, Dudareva V.A. , Maksimov M.L. ,   Kazan State Medical Academy — Branch of the Russian Medical Academy of Continuous  Professional Education, Kazan, Russian Federation, Djadikova I.G. ,   Rostov State Medical University, Rostov-on-Don, Russian Federation, Zveginceva A.A. ,   Kazan State Medical Academy — Branch of the Russian Medical Academy of Continuous  Professional Education, Kazan, Russian Federation, Vovk V.O. ,   Rostov Regional Clinical Hospital, Rostov-on-Don, Russian Federation, Shikaleva A.A. ,   Kazan State Medical University, Kazan, Russian Federation
Published: November 2020

Obesity that results in various metabolic disorders is one of the central concerns of modern healthcare system. Only 4% to 5% of patients with metabolic syndrome achieve favorable outcomes without any additional pharmacotherapy. Therefore, many patients require weight-loss drugs in addition to non-pharmacological treatments. The endocannabinoid system and the drugs that affect its functions receive a widespread attention of medical society due to its effects on behavioral and cerebral functions and its potential use as a therapeutic “target” in various peripheral and neurological psychiatric disorders. Among known to date cannabinoid receptors, type 1 receptors play a role in the development of obesity. It was demonstrated that the blockade of these receptors in the hypothalamus reduces appetite, inhibits adipocyte activation in peripheral tissues, prevents lipogenesis, and increases the level of adiponectin. The result is the decreased levels of atherogenic lipoproteins and improved insulin resistance. This article addresses the results of fundamental and clinical studies on Dietressa, a drug composed of affine-purified antibodies to cannabinoid receptor 1. Case report of a patient with obesity that analyzes pharmaceutical and non-pharmaceutical treatment approaches is described.KEYWORDS: obesity, metabolic syndrome, diet, endocannabinoid system, cannabinoids, cannabinoid receptors, affine-purified antibodies.FOR CITATION: Dudareva V.A., Maksimov M.L., Djadikova I.G. et al. Role of endocannabinoid system in the pathogenesis of obesity: how can we help a patient? From theory to practice. Russian Medical Inquiry. 2020;4(6):382–389. DOI: 10.32364/2587-6821-2020-4-6-382-389.
New prospects of the integrative therapy for polycystic ovary syndrome in women with the disorders of carbohydrate and lipid metabolism: a comparative study
Authors:   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Dobrokhotova Yu.E. , Lapina I.A. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Chirvon T.G. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Taranov V.V. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation
Published: November 2020

Background: long-term combined estrogen-progestin oral contraceptive pills (COCPs) are the first-line treatment for polycystic ovary syndrome (PCOS). However, this therapeutic option does not affect metabolic disorders that are more severe in women with the second PCOS phenotype thus increasing the risk of cardiometabolic complications.Aim: to assess the effect of myo-inositol and D-chiro-inositol at a 5:1 ratio on metabolic parameters in women of reproductive age with the second PCOS pathogenetic type and the disorders of carbohydrate and lipid metabolism. Patients and Methods: 60 overweight and obese women with PCOS were enrolled in this randomized prospective study. Group 1 women (n=30) received COCP and a drug containing two isoforms of inositol at a 5:1 ratio (myo-inositol 1,000 mg plus D-chiro inositol 200 mg). Group 2 women (n = 30) received COCP only. Hemostasis, lipid panel, fasting glucose level, body mass index (BMI), and waist circumference were measured before and 90 days after treatment begins. Results: in group 1, the significant (p<0.05) improvement of lipid parameters was reported as demonstrated by the reduction of the levels of total cholesterol (TC) by 16.9%, triglycerides by 15.7%, low-density lipoprotein cholesterol (LDL–C) by 17.8%, fibrinogen by 15.8%, and fasting glucose by 16.9% as well as the increase of high-density lipoprotein cholesterol (HDL–C) by 28.5%. Meanwhile, no significant changes were seen in group 2. Additionally, the reduction of waist circumference by 4.5% and BMI by 9.1% was reported in group 1. Conclusions: a medication containing myo-inositol and D-chiro-inositol at a 5:1 ratio is promising for the prevention of cardiometabolic complications in women with PCOS. Further large studies of the investigated drug are needed to demonstrate its efficacy and to assess its properties. KEYWORDS: polycystic ovary syndrome (PCOS), treatment, prevention, obesity, metabolic syndrome, lipid panel, inositol, oral contraceptive pills. FOR CITATION: Dobrokhotova Yu.E., Lapina I.A., Chirvon T.G., Taranov V.V. New prospects of the integrative therapy for polycystic ovary syndrome in women with the disorders of carbohydrate and lipid metabolism: a comparative study. Russian Journal of Woman and Child Health. 2020;3(3):169–173. DOI: 10.32364/2618-8430-2020-3-3-169-173.
Course of the pregnancy in women with connective tissue disorders
Authors:   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Il’ina I.Yu. , Chikisheva A.A. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation
Published: November 2020

This paper discusses connective tissue disorders (CTD), in particular, undifferentiated connective tissue disease (UCTD) whose importance is accounted for by a high prevalence of this condition. Generalized connective tissue damage that involves reproductive system significantly affects the course of pregnancy and delivery. The complications of pregnancy, delivery, and postpartum period in women with UCTD which often require surgical procedures (i.e., amniotomy, episiotomy, perineotomy, C-section etc.) are described. The paper highlights the role of magnesium which is of crucial importance for the complex biosynthesis of extracellular matrix during connective tissue formation and fibroblast morphological functional status. The tests for connective tissue metabolic disorders (blood oxyproline and fibronectin, urine pyrilinks-D and glycosaminoglycans etc.) are addressed. Considering the lack of the reliable diagnostic (biochemical and genetic) criteria for UCTD, the authors advocate the need for a complex examination using anamnestic data and the results of clinical, instrumental, and laboratory tests.KEYWORDS: connective tissue disorders, hemostasis, complications of pregnancy and delivery, magnesium deficiency, endothelial dysfunction, markers of collagen degradation, genital prolapse.FOR CITATION: Il’ina I.Yu., Chikisheva A.A. Course of the pregnancy in women with connective tissue disorders. Russian Journal of Woman and Child Health. 2020;3(3):182–188. DOI: 10.32364/2618-8430-2020-3-3-182-188
Climacteric syndrome. A nutritional approach to treatment
Authors:   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Saprykina L.V. , Narimanova M.R. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Ibragimova D.M. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation
Published: November 2020

Female sex hormones are of crucial importance for a woman’s life. Almost all women over 40 irrespective of their origin or social status begin to experience physical, psychologic, and emotional problems. Menopause hormone therapy (MHT) is considered the most effective option to improve various symptoms of climacteric syndrome. Non-hormonal treatment can be an alternative to MHT to relieve the symptoms of climacteric symptoms in pre- and postmenopausal women, in particular, in contraindications or reluctance to take MHT. The paper addresses recent findings on the effects of soy isoflavones, β-alanine, tryptophan, and vitamins on tissues and the quality of life of pre- and postmenopausal women. Mense® (JC «Akvion»), a biologically active supplement that contains phytoestrogens, vitamins, and amino acids, is characterized by a variety of protective effects in pre- and postmenopausal periods. This biologically active supplement can be recommended for women with the symptoms of climacteric syndrome as a pretreatment during the screening before prescribing MHT, a dietary modification in contraindications or refusal of MHT, and/or an effective component of the complex treatment for climacteric syndrome.KEYWORDS: perimenopause, postmenopause, non-hormonal treatment, menopause hormone therapy, vasomotor symptoms, phytoestrogens, vitamins.FOR CITATION: Saprykina L.V., Narimanova M.R., Ibragimova D.M. Climacteric syndrome. A nutritional approach to treatment. Russian Journal of Woman and Child Health. 2020;3(3):189–193. DOI: 10.32364/2618-8430-2020-3-3-189-193.
Efficacy of metronidazole and miconazole vaginal co-formulation for bacterial vaginosis and vulvovaginal candidiasis
Authors:   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Markova E.A.
Published: November 2020

Recurrent vulvovaginal infections being an epidemiological and clinical issue also have social and psychological implications. As a result, the development of the effective diagnostic strategies and therapeutic approaches to female genital infections is important. This paper reviews the most common vulvovaginal infections, i.e., bacterial vaginosis and vulvovaginal candidiasis. Topical metronidazole and miconazole vaginal dosage forms prescribed for these relevant obstetrical gynecological disorders are highlighted. Although numerous domestic and foreign publications on the clinical efficacy of this combination are available, dose reductions and the minimum therapeutically effective doses for bacterial vaginosis, vulvovaginal candidiasis, and mixed vaginitis are still challenging entities. The data on the efficacy of a novel dosage form, Gynocaps® vaginal capsules, containing low doses of miconazole (100 mg) and metronidazole (100 mg) are addressed. The treatment has resulted in microbiological cleaning, the normalization of vaginal WBC count, and the improvement of vaginal florocenosis. In addition, easy-to-use vaginal capsules ensure treatment adherence.KEYWORDS: bacterial vaginosis, vulvovaginal candidiasis, metronidazole, miconazole nitrate, vaginal capsules.FOR CITATION: Markova E.A. Efficacy of metronidazole and miconazole vaginal co-formulation for bacterial vaginosis and vulvovaginal candidiasis. Russian Journal of Woman and Child Health. 2020;3(3):205–210. DOI: 10.32364/2618-8430-2020-3-3-205-210.
Burkitt’s lymphoma and pregnancy. Advantages of today’s medicine
Authors:   City Clinical Hospital No. 52, Moscow, Russian Federation, Kotomina T.S. , Baryakh E.A. ,   City Clinical Hospital No. 52, Moscow, Russian Federation, Misyurina E.N. ,   City Clinical Hospital No. 52, Moscow, Russian Federation, Zhelnova E.I. ,   City Clinical Hospital No. 52, Moscow, Russian Federation, Kokoya I.Yu. ,   City Clinical Hospital No. 52, Moscow, Russian Federation, Grabovskiy V.M. ,   City Clinical Hospital No. 52, Moscow, Russian Federation, Lysenko M.A. ,   City Clinical Hospital No. 52, Moscow, Russian Federation
Published: November 2020

Recent years have seen the increase in the rate of childbirth after the age of 30 years. This is associated with higher risks for a mother and a child as well as higher rate of cancers diagnosed during pregnancy including non-Hodgkin’s lymphoma (NHL). The data on pregnancy-associated NHLs are limited by individual case studies. This makes difficult to develop a therapeutic strategy for lymphoma and pregnancy management in women with hematologic malignancies. The paper addresses the case study of a rare combination of Burkitt’s lymphoma and pregnancy. At 20 weeks of the pregnancy, right ovarian tumor was identified by magnetic resonance imaging. Burkitt’s lymphoma was verified by the biopsy of the excised ovary. Progressive tumor growth required chemotherapy. R-DA-EPOCH chemotherapy program was successful and also allowed for pregnancy prolongation and led to favorable perinatal outcome.KEYWORDS: pregnancy, Burkitt’s lymphoma, non-Hodgkin’s lymphoma, chemotherapy, remission, adnexectomy.FOR CITATION: Kotomina T.S., Baryakh E.A., Misyurina E.N. et al. Burkitt’s lymphoma and pregnancy. Advantages of today’s medicine. Russian Journal of Woman and Child Health. 2020;3(3):211–216. DOI: 10.32364/2618-8430-2020-3-3-211-216
Redefinisi Nusyûz dengan Pendekatan Maqâṣid Asy-Syarî’ah
Authors: Labibah Umniyatul
Published: November 2020

Konsep nusyuz selama ini didefinisikan sebagai durhaka istri kepada suami. Definisi ini memposisikan perempuan sepihak sebagai objek dan secara terbuka memberi peluang terjadinya kekerasan kepada istri (perempuan). Definisi yang lebih egaliter dilakukan oelh beberapa ulama, diantaranya Sayyid Qutub yang mendefinisikan nusyuz sebagaiketidakharmonisan dalam keluarga. Begitu pula Assad, mendefinisikan nusyuz sebagai kejahatan mental. Dari sinilah, Amina wadud memberikan solusi bahwa pemukulan sebenarnya sesuatu yang tidak diperlukan, karena alih-alih akan mengembalikan keharmonisan keluarga justru malah memperuncing permasalahan. Dan kekerasan terhadap istri (perempuan) tidak sejalan dengan maqashid al-Syariah, yaitu penghormatan terhadap hak dasar kemanusiaan istri (perempuan).
Korelasi Al-Îjâz dan Al-Iṭnâb dengan Maqâṣid As-Suar (Studi dalam Kisah Nabi Musa a.s.)
Authors: Fajria Nura
Published: November 2020

Al- ȋjaz dan al-ȋtnȃb merupakan cabang dari ilmu  ma’ni dalam balaghah, Redaksi al- ȋjaz dan al- ȋtnȃb terkadang di gunakan dalam Al-Qur’an untuk mengungkapakan maksud dan tujuan dari pemaparan ayat-ayatnya, terkadang redaksi ayat begitu simpel namun mengandung arti yang luas dan dalam, dan terkadang ayat Al-Qur’an menggunakan redaksi yang panjang guna menjelaskan dan menguatkan suatu keterangan ayat, sebagai contoh dalam kisah Nabi Musa a.s yang terdapat dalam surat Tȃhȃ, sebagaian besar redaksi ayatnya sedemikian simpel(al- ȋjaz) mempunyai hubungan dengan maqȃsid as-suar surat Tȃhȃ yaitu menjelaskan kemudahan dan pertolongan yang Allah berikan kepada para NabiNya, dengan terkabulnya permohonan Nabi Musa a.s untuk menjadikan saudaranya nabi Harun a.s sebagi patner dakwah kepada Fir’au.
Kuasa Pengetahuan Masyarakat dan Analisis Hirarki Maqâṣid Syarî’ah terhadap Fatwa MUI tentang Pencegahan Penyebaran Covid-19
Authors: Auladi Akrom
Published: November 2020

Kebijakan pemerintah dalam rangka mencegah tersebarnya Covid-19 memunculkan persoalan dalam beberapa bidang, salah satunya adalah bidang keagamaan. MUI yang notabenya merupakan lembaga  paling otoritatif bagi umat Islam di Indonesia telah mengeluarkan fatwa tentang penyelenggaran ibadah dalam kondisi terjadinya wabah Covid-19. Fatwa ini kemudian direspon beragam oleh masyarakat. Berkaitan dengan hal tersebut, penulis terdorong untuk mengkaji teori kuasa pengetahuan dari Michele Fouchoult untuk menganalisis bangunan pengetahuan masyarakat sehingga muncul kuasa yang berupa resistansi terhadap poin-poin dalam fatwa MUI. Penulis juga terdorong untuk mengelaborasi konstruk hirarki Maqasid syariah dalam rangka menemukan konsep ideal ushulul khomsah terutama ketika terjadi pertentangan antar setiap perlindungan, dimana konsep tersebut akan dijadikan sebagai pisau analisis fatwa MUI tersebut.Hasil dari penelitian ini menunjukkan bahwa pengetahuan masyarakat tentang konsep dalam beragama punya andil dalam merespon Fatwa MUI tersebut. Resistensi dalam bentuk penolakan ataupun pengabaian merupakan kuasa yang lahir dari wacana keagamaan yang menjadikan Agama sebagai puncak kulminatif dalam setiap hal. Disisi lain, jika ditinjau dari analisi hirarki maqasid syariah, konstruk tentang hifdzu din tidak selamanya didahulukan. Sebagaimana yang dijelaskan oleh Al-Buthi, Hirarki tersebut selain bergantung pada tingkat keniscayaan (dhoruriyat, hajiat, tahsiniat) juga tergantung pada identifikasi kepastian maslahat yang ada dalam setiap perlindungan. Sehingga dalam persoalan fatwa MUI tentang larangan solat Jumat itu tersendiri, kepastian maslahat dalam hifdzu nafs menjadi landasan dalam praktek mengakhirkan hifdzu din.
Zakat dan Paradigma Pemberdayaan Ekonomi Umat
Authors: Handoyo Handoyo , Khanifa Nurma Khusna
Published: November 2020

Zakat merupakan salah satu rukun Islam yang pelaksanaannya didasarkan pada syariat. Selain sebagai sebuah ritual ibadah, zakat juga merupakan ibadah sosial dan memiliki dimensi spiritual dan dimensi sosial. Dimana dimensi spritual, zakat dapat membersihkan atau mensucikan jiwa pemilik harta dari sifat tama’, syirik, kikir, dan bakhil. Kemudian dimensi yang bersifat sosial, zakat dapat dipergunakan sebagai sarana pemerataan pendapatan masyarakat melalui pemberdayaan ekonomi umat. Zakat sebagai upaya pemberdayaan ekonomi umat dapat digali potensinya agar dapat berperan aktif dalam pengentasan kemiskinan umat. Sehingga, implementasinya dapat memberi keselarasan dalam kehidupan sosial dan ekonomi manusia.
İdrar İnkontinasının Nadir Nedeni Olan Ektopik Üreter Tanısında Anamnezin Yeri ve Tedavisinde Minimal İnvaziv Cerrahi Uygulaması
Authors: AYDIN Yavuz Mert , ÇİÇEK Mehmet , ERDEMLİ GÜRSEL Başak , KAYGİSİZ Onur
Published: November 2020

Bu olgu sunumunun amacı idrar kaçırma şikayeti ile başvuran kız çocuklarında ayrıntılı anamnez ile ektopik üreter tanısı konması ve minimal invaziv yöntemle tedavi edilerek şifa sağlanması konusunda bilgi vermektir.11 yaşında kız hasta, tuvalet eğitiminin tamamlanmasından beri olan, idrar kaçırma şikayetiyle başvurdu. Hasta daha önce farklı merkezlerde birçok defa muayene edilmiş ve işeme disfonksiyonu tanısıyla tedavi edilmiş. Fakat tedaviden fayda görmemişti. Anamnezinde sürekli idrarı kaçırması mevcuttu. Urgency bulgusu yoktu. Fizik muayenede herhangi bir orta hat defekti saptanmadı. Yapılan üroflowmetri testinde patolojik bulgu yoktu. Hastanın üriner sistem ultrasonografi tetkikinde patolojik bulgu yoktu. Bu bulgular ışığında ektopik üreter olasılığı düşünülerek Manyetik Rezonans (MR) Ürografi istendi. MR Ürografi tetkikinde; sol böbrek üst polünün displastik görünümde olduğu, üst polü drene eden üreterin geniş olduğu ve sol üreterin vajina üst-arka duvarına ektopik olarak açıldığı görüldü. Statik Böbrek Sintigrafisi (DMSA) tetkikinde; sol böbrek üst poldeki displastik alanın nonfonksiyone olduğu görüldü. Bu bulgular sonucunda hastaya laparoskopik parsiyel nefrektomi + üreterektomi yapıldı. Ameliyat süresi 120 dakika, tahmini kan kan kaybı 40 ml olarak tespit edildi. Hastanın postoperatif birinci gününde sondası, ikinci gününde dreni çekilerek hasta şifa ile taburcu edildi. Ameliyat spesmeninin patoloji sonucu displastik böbrek ile uyumlu idi. Postoperatif 15. gün, 1. ve 3 aydaki kontrol muayenelerinde, hastanın inkontinans şikayetlerinin tamamen geçtiği görüldü. Sonuç olarak idrar kaçırma şikayeti ile başvuran hastalarda tedaviye yanıt yoksa, ayırıcı tanıda ektopik üreter mutlaka düşünülmelidir. Tedavisinde başarı oranı yüksek ve minimal invaziv bir yöntem olan laparoskopi tercih edilmelidir.
Effect of Black Pepper Extract (Piper nigrum L) towards Streptococcus Mutans Growth
Authors: Hakim Rachmi Fanani , Fakhrurrazi  , Alwi Fadli
Published: November 2020

Streptococcus mutans is a Gram-positive facultative anaerobic bacteria which has become the main cause of dental caries. Black pepper (Piper nigrum L ) is one of herbal plants that compose antibacterial compounds including alkaloids, flavonoids, tannins, and essential oils. This study aims to determine the effect of black pepper (Piper nigrum L.) extract to inhibit of Streptococcus mutansgrowth. Black pepper extracts ware made by using maceration method. The effect of black pepper extract ( Piper nigrum L. ) in inhibition of Streptococcus mutansgrowth by using the disc diffusion method on Mueller Hinton Agar media. The concentration of black pepper ( Piper nigrum L.) extracts used in this study were 6.25%, 12.5%, 25%, 50%, 75%. The results of this study were analyzed by using the one-way ANOVA test showed that there was significant effect of black pepper extract on Streptococcus mutans growth with p-value (p <0.05), and then the data was tested by Least Significant Difference (LSD). Conclusion of this study showed that there was an effect of black pepper ( Piper nigrum L.) extract in inhibition of Streptococcus mutans growth with concentrations 75% is the optimum concentration which value 16.8 mm.
Follow-up form for adult patients with leukemia using Imatinib
Authors: Sbruzzi Felipe Augusto , Silva Kelly Cristina da , Telles Sérgio Mazero , Lima Sirlene de Sousa , Santana Claudinei Alves
Published: November 2020

Introduction: Chronic Myeloid Leukemia is a type of malignant blood neoplasia that is mainly characterized by the presence of the Philadelphia chromosome that originates the oncoprotein BCR-ABL. It has increased tyrosine kinase activity, thus causing changes in intracellular signaling pathways and promoting uncontrolled proliferation, cellular dysfunction and absence of apoptosis. Despite the low incidence of the disease, 1.5 cases per 100,000 inhabitants, therapy with Imatinib, a potent inhibitor of BCR-ABL, changed the prognosis of the disease and extended the life expectancy of patients, transforming a fatal disease into a chronic condition. Objective: To develop a form for regular monitoring of these patients by the clinical pharmacist to ensure safe and effective pharmacotherapy. Methodology: Narrative-type literature review was initiated from the problem question: ‘“What data should be collected by the Clinical Pharmacist during pharmaceutical assistance to assess and improve adherence in adult patients with Chronic Myeloid Leukemia using Imatinib?” , followed by search for articles in PubMed databases and government websites. Subsequently, work selection and critical analysis were carried out to build a model form to be applied in the act of dispensing. Result and Discussion. Eleven articles were selected. The patient’s low adherence to the treatment of chronic myeloid leukemia can result in potentially life-threatening. Therefore, the follow-up form to be applied by the clinical pharmacist when dispensing imatinib mesylate is a viable and low-cost strategy to improve adherence to pharmacotherapy and promote a better response to treatment. Conclusion: The systematic and standardized documentation of adherence and adverse effects by the Clinical pharmacist allows the implementation of actions by the multidisciplinary team of continuous improvements in order to maximize the quality of care provided to patients as well as the quality of life.
Studies on the selection of domestic viscosity additives for multi-grade hydraulic oils HVLP
Authors:   JSC «Middle Volga Oil Refining Resarch Institute» (JSC «MidVolgaNIINP», Radchenko L. A. , Morshanskaya Yu. A. ,   JSC «Middle Volga Oil Refning Research Institute» (JSC «MidVolgaNIINP», Beskova A. V. ,   JSC «Middle Volga Oil Refinng Research Institute» (JSC «MidVolgaNIINP», Zhumlyakova M. A. ,   JSC «Middle Volga Oil Refining Research Institute» (JSC «MidVolgaNIINP», Tyschenko V. A. ,   JSC «Middle Volga Oil Refining Research Institute» (JSC «MidVolgaNIINP»
Published: November 2020

At the present time, imported viscosity additives purchased abroad are used to produce premium multi-grade hydraulic oils in Russia. The high technology production such oils is entirely dependent on the import of these additives. At the JSC "MidVolgaNIINP" conducted research on the development and selection of domestic viscosity additives is not inferior to foreign analogues in the composition of hydraulic oils of the HVLP. For select the domestic viscous additive of optimal quality were studied three laboratory samples of polyalkyl methacrylate additives in physicochemical and operational properties in base oil. The results obtained were selected a domestic viscosity additive with a narrow molecular-mass distribution (2.19 Р) and a minimal weighted average molecular weight (34983 Da) that allows hydraulic oils to meet the requirements DIN 51524-3 and OEM. Studies had found that the quality of thickened oils is affected by the content viscous additive. The optimal contents of domestic additives for obtaining oils of viscosity levels ISO VG 32 and ISO VG 46 have been determined. The results are used in further research on the development of multi-grade hydraulic oils HVLP.
Basic Theoretical Thesises of Chemmotology
Authors:   FAE «The 25th State Research Institute of Himmotology of Ministry of Defense of the Russian Federation», Grishin N.N. , Sereda V.V. ,   FAE «The 25th State Research Institute of Himmotology of Ministry of Defense of the Russian Federation»
Published: November 2020

Toward the end of the 20th century fundamental theories of oxidation, combustion, friction, deterioration, corrosion and others were adapted to chemmotology systems: proposed an oscillatory-homogenous theory of the formation of free radicals in hydrocarbonated nature; demonstrated unsuitability of “physical” model of combustion for a description of working processes of engines; worked out a theory of boundary processes of grease and friction as applied with conjugate details; worked out the general patterns of tribochemical reactions in lubricant nature; developed the basis of theory of physico-chemical mechanics of pseudocolloidal systems. At the present moment established the general patterns of the effect of quality of combustion and composition of fuel during the period of delay of ignition, speed and volume of burning of hydrocarbons ; worked out a concept of quasiciliary formation of fuels, defining their condition of metastable state; proposed mechanism of abnormally - fast internally flaming gasification of dispersing carbohydrate ; worked out an electro-kinetical model of quality state of engine oils in static and dynamic conditions and many others . Introduction of relevant theoretical basis will provide quantitative description of chemotological processes.
Faktor yang Mempengaruhi Kesetiaan Terhadap Organisasi di Kalangan Penjawat Awam
Authors: YAHYA KHULIDA KIRANA , JOHARI JOHANIM , ADNAN ZURINA , MOHD ISA MOHD FAIZAL , DAUD ZULKIFLEE
Published: November 2020

This study was conducted to identify factors influencing loyalty towards organization among exempt and non-exempt employees in the government sector. Factors examined are management support, career development, job security, training and development, and compensation. Data collected through self-administered questionnaires, whereby 356 sets were distributed and 349 sets (98.03%) were analyzed. Pearson Correlation and Multiple Regression analyses were used to analyze the data. Findings indicate that all factors examined have positive correlation with the loyalty among employees. Regression analysis showed that management support, job security, and training and development have influenced on the level of loyalty among employees towards organization. Therefore, it is crucial for the top management to take into account these factors in improving loyalty among employees.
Penuaan Penduduk dan Permasalahannya di Indonesia
Authors: ASTINA I KOMANG ASTINA , WAN AHMAD WAN IBRAHIM
Published: November 2020

Population aging is a 21 st century phenomenon. The population aging occurs as the proportion of older people relative to younger group increases. This process has creating various problems not only for developed countries but also developing countries. The population of Indonesia also has shown signs of aging. As age of the population increases, and many people are living longer, there will be many more elderly in the society. This article discusses the population aging in Indonesia and discusses the problems resulting from the population aging.
Religiositi dan Kebimbangan dalam Kalangan Mangsa Banjir di Daerah Kubang Pasu, Kedah
Authors: ABU BAKAR MD ZAWAWI , WAN ABDULLAH WAN AB RAHMAN KHUDZRI , WAN AHMAD WAN IBRAHIM , MAHAMOOD YAHAYA , SHAFFIE FUZIAH
Published: November 2020

Anxiety can arise due to various causes. Uncertainty and failure to anticipate any tragedy can induce fear differently among people. Flood tragedy may draw worries among those who had experienced it before. Anxiety is related with coping strategies to deal with it. One of the coping strategies is religious practice. This study is aimed to identify the level of religiosity and to explore the signs of anxiety among flood victims in Kubang Pasu district, Kedah. To meet the objectives, a total of 113 residents in Kubang Pasu, Kedah were purposively selected as respondents. The study found the religiosity level of most respondents is high. The study also found that flood victims show several signs of anxiety such as inability to relax, afraid of bad things happening, rapid heart rate, feeling not strong, fear, anxiety, worried and fear of death. They use religious practices such as reciting prayer, performing solat or reading the Qur’an to face the flood. In conclusion, Islamic practices can be used by victims when coping with any disasters, especially floods.
DISENTANGLING THE SIGNIFICANT OF IMPROVISATIONAL BEHAVIOR ON WOMEN ENTREPRENEURS’ BUSINESS SUCCESS
Authors: Bari Adibah , Arshad Darwina
Published: November 2020

Previous research indicates that improvisation as deliberate extemporaneous composition and execution of novel actionis an important matter for any business to be successful. The present article seeks to advance the theoretical knowledge on the influence of improvisation behavior on business success, particularly among women entrepreneur by reviewing and synthesizing available research into a conceptual framework that the relationship of the selected variables. Based on the arguments in this article, a proposition was developed to refine our understanding of the relationship between improvisation and business success. Finally, theoretical and practical implication were discussed.
DESIGNS OF PISA-LIKE ASSIGNMENTS WITH YOGYAKARTA CONTEXTTO DETERMINE STUDENTS' LITERACY ABILITIES
Authors: Rokhima Nur , Suparman Suparman
Published: November 2020

This study aims to develop the need to create PISA type problems using the Yogyakarta context that is designed to obtain student literacy skills. This research is a type of development research by adapting the Tessmer development model. This research was carried out in two stages, namely the preliminary stage, starting from the preparation and design, then the evaluation stage, which included self-evaluation, prototype making, small groups, and field tests. This research is limited to making prototypes. Thesubjects of this study were grade IX students of SMP Negeri 3 Depok, Indonesia. Data collection instruments consist of a collection of observations, interview guidelines, documentation sheets, and questionnaires. Data were analyzed with qualitative and quantitative techniques. The results showed that the design of the type of PISA that had been developed was declared valid; it could be used in the development of small groups and field tests. Thus, PISA design in the Yogyakarta context can be used by students, both with low, medium, and high abilities according to the needs of students in the industrial revolution era 4.0.
THE CORRELATION BETWEEN FAMILY’S ECONOMIC SOCIALWITH THE BUSINESS INTEREST IN BEAUTY
Authors: Warsihapsari Tri , Abdullah Raja Nazim
Published: November 2020

This paper seeks to determine the relationship between socio-economic family and interest in entrepreneurship in the field of beauty at the Akademi Kesejahteraan Sosial Yogyakarta. This paper used correlation analysis approach to gather information from respondents. This study used a set of questionnaire to measure variables used in this study. Hypotheses were tested using non-parametric statistical methods to determine whether there is a relationship between socioeconomic family and interest in entrepreneurship in the field of beauty. The results showed that there was a significant relationship between socioeconomic family and interest in entrepreneurship with a moderate closure relationship of 0.371. Each variable in the results of data processing have a significant result in the interest of entrepreneurship with the result shown 27 (90%), and the socio-economic sector that has the largest entrepreneurial interest in income of 1 million-2.5 million (IDR) by 10 (33.3%). The results in the study of socioeconomic relations and interest in entrepreneurship were attracted by 15 (50%) and very interested in 12 (40%). This study has a significant result between socio-economic families with interest in entrepreneurship by reaching 90% of respondents surveyed turned out to have an interest in entrepreneurship. At low socioeconomic has greater entrepreneurial desire, someone at low socioeconomic family wants to improve their lives by entrepreneurship in one of the beauty procedures.