bluuebunny/crossref_metadata_2025 huggingface dataset:
Sterol-targeted laboratory evolution allows the isolation of thermotolerant and respiratory-competent clones of the industrial yeast Saccharomyces cerevisiae
Authors: Sánchez-Adriá Isabel-Elena , Prieto Jose A. , Sanmartín Gemma , Morard Miguel , Estruch Francisco , Randez-Gil Francisca
Published: December 2023

Background
Evidence suggests that sterol content and composition play an important role in the ability of yeast cells to face high temperatures. Nevertheless, our knowledge of the exact mechanisms operating is still scarce, which makes the rational engineering of this industrial-relevant trait difficult. Here, we have used a fluconazole (FCNZ)-driven experimental evolution approach with the idea of inducing changes in the sterol biosynthesis pathway linked to high temperature tolerance.
Results
The evolution experiment rendered a FCNZ-resistant population of a previously selected baker’s yeast strain, from which six isolates with increased thermotolerance were rescued. Initial characterization of evolved clones grouped them into two sets, based on their respiratory competence or deficiency. This late was connected to mtDNA loss, an event that appears to induce FCNZ and heat tolerance. Genome sequencing and ploidy-level analysis of all strains revealed aneuploidies, CNVs, and SNPs, which could contribute to phenotypic heterogeneity. In particular, all evolved clones showed a specific point mutation in MPM1 and PDR1, this late, a well-known gene involved in FCNZ-tolerance. In addition, fragment amplifications of Chr IV and XIV, which harbour dosage-sensitive genes, and specific SNPs in thermotolerance genes (AVT3, SFP1 and RNT1), could be on the basis of the phenotype of respiratory-competent evolved clones. Finally, all the evolved clones showed changes in their profiles of ergosterol biosynthesis intermediates, which again were different in respiratory-competent and –defective strains.
Conclusions
Our experimental evolution allowed us to generate fully competent industrial strains with better performance at high temperatures, and identify new determinants of fluconazole and heat tolerance.
Ultrasound-based deep learning radiomics nomogram for comprehensive prediction of tumor, axillary lymph node status and prognosis of breast cancer patients after neoadjuvant chemotherapy
Authors: Liu YueXia , Liu QingHua , Hu QuanHui , Shi JiaYao , Liu GuiLian , Liu Han , Shu ShengChun
Published: December 2023

Objectives Our study aims to explore the feasibility of the deep learning radiomics nomogram (DLRN) for predicting the status of tumors and axillary lymph node metastasis (ALNM) after neoadjuvant chemotherapy (NAC) in breast cancer patients, and employ a Cox regression model for survival analysis to validate the effectiveness of the fusion algorithm.
Methods A total of 243 patients who underwent NAC were retrospectively included between October 2014 and July 2022. The DLRN integrated clinical characteristics as well as radiomics and deep transfer learning features extracted from ultrasound images. Evaluating the diagnostic performance of DLRN by constructing ROC curve , and assessing the clinical usefulness of models by using decision curve analysis (DCA). A survival model was developed to validate the effectiveness of the fusion algorithm.
Results In the training cohort, the DLRN yielded an area under the receiver operating characteristic curve (AUC) values of 0.984 and 0.985 in the tumor and LNM, while 0.892 and 0.870, respectively, in the test cohort. The consistency index (C-index) of the nomogram was 0.761 and 0.731, respectively, in the training and test cohort.The Kaplan-Meier survival curves showed that patients in the high-risk group had significantly poorer overall survival than patients in the low-risk group (P<0.05).
Conclusion The US-based DLRN model could hold promise as a clinical guidance for predicting the status of tumor and LNM after NAC in breast cancer patients. This fusion model also can predict the prognosis of patients , which could help clinicians to make better clinical decisions.
HSF1 is a direct sensor of proteotoxic stress.
Authors: Muller Petr , Simoncik Oliver , Tichy Vlastimil , Durech Michal , Hernychova Lenka , Trcka Filip , Uhrik Lukas , Bardelcik Miroslav , Coates Philip , Vojtesek Borivoj
Published: December 2023

Stress responses play a pivotal role in normal physiology, a feature exploited by cancer cells to facilitate growth, counteract genomic instability, and resist therapeutic stress. Heat shock factor-1 (HSF1), a major stress-response transcription factor, exhibits a significant upregulation in activity in cancer. While HSF1's role in transcription is relatively well-known, the mechanisms governing its activation, particularly in tumors, remain unclear. To determine whether HSF1 is the primary sensor of proteotoxic stress, we studied the range of conditions that modulate HSF1 activation both in vitro and in cells. We show that purified HSF1 adopts a stable monomeric conformation in vitro. Conditions that lead to protein denaturation, such as heat stress, molecular crowding, Hsp90 inhibition, and proteasome inhibition, directly trigger the activation of HSF1 by inducing conformational changes and trimer assembly. In contrast, proteosynthesis inhibition prevents HSF1 activation by reducing denatured proteins in the cell. Our findings highlight HSF1 as a direct sensor of proteotoxic stress, independent of post-translational modifications and molecular chaperones. Abrupt environmental changes causing protein denaturation induce a conformational change in monomeric HSF1, explaining the universal cellular response to proteotoxic stress. This activation mechanism underscores the cells' ability to initiate a protective response, enhancing chaperone activities to restore homeostasis.
The Clinical Efficacy of single-hole Punch Excision Combined With Intralesional Steroid Injection for Nodular Keloid Treatment
Authors: Liu Bingbing , Lin Haoying , Zhang Minghai
Published: December 2023

There are many methods to treat keloid, including various excision operations,laser, injection and radiotherapy.However, few studies have explored the effectiveness of single-hole punch excision in keloid treatment.This study aimed to investigate the efficacy and safety of lateral punch excision combined with intralesional steroid injection for keloid treatment through self-control experiment.In this self-controlled trial, all patients meet the diagnosis of nodular keloid, and try to choose left-right symmetrical control, one in the control group (50 in total) and the other in the observation group (50 in total).The keloids in the treatment group were initially treated with punch excision combined with intralesional steroid injection, followed by injection treatment alone. Keloids in the control group received intralesional steroid injection alone.The Vancouver Scar Scale (VSS)of the keloid before and after the punch excision wasevaluated; the keloid scores at different time points and the number of injection treatments required in both groups were compared, and adverse reactions were observed.The effective rate of the observation group was 86.0%, which was significantly higher than that of the control group (66.0%), and the recurrence rate of 22% was lower than that of the control group (χ2 = 4.141,63417), all of which were statistically significant (all P < 0.05). At the end of treatment, the VSS and total injection times in the observation group were significantly lower than those in the control group (t = 5.900,3.361), with statistical significance (P < 0.01).The combination of single-hole punch excision and intralesional steroid injection is an effective method to treat multiple nodular keloids, shortening the treatment course of tralesional steroid injection without obvious adverse reactions.
High-percentage new energy distribution network line loss frequency division prediction based on wavelet transform and BIGRU-LSTM
Authors: Wu Xiangming , Song Nan , Liang Jifeng , Lv Ye , Wang Zitian , Yang LIjun
Published: December 2023

With the large-scale integration of new energy sources, the control complexity of the distribution network has substantially increased, thereby complicating the mechanisms and factors affecting power loss. Traditional power loss calculation methods have become inadequate. Addressing this challenge, we propose a novel power loss frequency-decomposition prediction model that integrates wavelet transform with BIGRU-LSTM, significantly enhancing the prediction accuracy and adaptability for power loss in distribution networks with a high proportion of new energy. Key temporal and non-temporal feature parameters were selected from electrical and environmental characteristics using grey relational analysis and the NARMA method to construct a multidimensional feature dataset. A predictive architecture combining wavelet transform with BIGRU-LSTM was developed, where historical power loss data were decomposed into frequency components to form a multidimensional input for the network prediction. The BIGRU-LSTM network facilitated frequency-decomposition prediction of the components using deterministic and probabilistic prediction channels. The results were then reconstructed using inverse wavelet transform to produce power loss prediction intervals. Simulation examples validated the effectiveness and suitability of the proposed prediction model.
Performance Evaluation Of The Deep Learning System For Weed Recognization
Authors: Mosslah Abd Abrahim , Mahdi Reyadh Hazim , Al-Barzinji Shokhan M.
Published: December 2023

Numerous approaches based on machine learning have emerged in recent years to enhance crop protection efficiency. One example is the utilisation of deep neural networks to differentiate between various weed types in actual event scenarios. Nevertheless, these methods often need substantial input from experts who work iteratively to design robust deep learning systems. To simplify such processes and conserve resources, researchers have explored a fresh method known as automated deep learning. The our technology's recognition of weeds through the use of machine learning was evaluated using plant seedlings and weed collection from plants as a dataset to address the issue of weed recognition. The study compared various configurations, including plant segmentation, using a collection of classifiers in place of Softmax, and training on datasets that contain noise. The findings indicated ensuring performance, with F1-scores of 93.1% and 90.2% based on the dataset utilised. These results align with AutoML-linked studies while falling short of manually fine-tuned deep-learning-based systems created by human specialists. To conclude, exploring the potential of combining manual expert work and automated deep learning could be a promising direction for enhancing efficiency in plant defence.
Transforming healthcare: A pilot study to improve primary healthcare professionals’ self- management support behaviour through blended learning
Authors: Timmermans Lotte , Decat Peter , Foulon Veerle , Hecke Ann Van , Vermandere Mieke , Schoenmakers Birgitte
Published: December 2023

Background: Self-management of a chronic condition is a complex but increasingly important issue. However, a supportive attitude and behaviour among healthcare professionals is hampered by a lack of awareness, knowledge and motivation. In addition, the role of professionals in supporting self-management seems unclear.
Methods: A blended learning program for primary healthcare professionals was developed to strengthen self-management support in primary care. The program was piloted in community health centres and multidisciplinary medical practices in Flanders. Using the Kirkpatrick model, the impact on healthcare professionals’ reaction, learning and behaviour regarding self-management support was evaluated.
Results: A total of 60 healthcare professionals registered for the educational program. Post-learning questionnaires and verbal feedback showed a positive response, with professionals highly appreciating the innovative blended learning approach. In terms of learning, participants showed a good understanding of self-management support, although nuances were observed in the application of acquired knowledge to practice scenarios. Finally, preliminary insights into behavioural change were explored, revealing a positive impact of the intervention on participants’ supportive self-management behaviours in healthcare practice.
Conclusions: Our study provides preliminary evidence of the impact of a blended learning program in raising awareness and providing knowledge to professionals about self-management support. The program needs to be refined for general implementation in primary care.
Identifying contemporary challenges pertaining to Distributed Software Development using Fuzzy Delphi Method
Authors: Gul Maimoona , Alam Khubaib Amjad
Published: December 2023

Distributed Software Development (DSD) is a process in which team members are located in different geographical locations and collaborate using communication and collaboration tools. DSD has gained prominence in recent years, driven by the surge in globalization, the rapid expansion of the IT outsourcing market, and the widespread accessibility of high-speed internet. However, DSD also presents numerous challenges, including team dynamics, employee well-being, HR management, communication & collaboration, requirements management, tooling & infrastructure, and development process & risk management issues. This paper aims at identifying critical challenges related to DSD. Initially, a systematic literature review was conducted to construct an initial list of 77 challenges; subsequently, a Fuzzy Delphi Method (FDM) survey was adopted to identify the critical challenges in this context. Results of the FDM indicate that, out of the 41 screened-out challenges, differences in work ethics & practices, language barriers, meeting scheduling difficulties, different time zones, burnout, physical fatigue/mental stress, and lack of opportunities for personal development are the most critical challenges of DSD. The findings of this study have implications for both practitioners and researchers related to DSD.
Factor Influencing Recruitment of Training and Development in Automobile Industry
Authors: Anika Afrin , Islam Mahia , Ahmed Farhad
Published: December 2023

This quantitative research delves into the recruiting, training, and development practices within the expanding automobile industry in Bangladesh. The primary goal is to analyze how these human resources practices influence employee retention and organizational performance. Over the past decade, the automotive sector has become the third-largest contributor to the nation's manufacturing GDP, propelled by increasing consumer demand, rising disposable income, and supportive government policies. Effective recruitment, training, and development strategies are vital for cultivating a skilled and motivated workforce within automobile companies. Recruitment strategies must align with the unique requirements of the industry, attracting candidates with technical proficiency and adaptability. Both traditional and modern recruitment methods, such as social media and online platforms, have proven successful in attracting highly qualified personnel. Training and development programs are crucial for enhancing employee competencies, job performance, and overall job satisfaction. Various methods, including on-the-job training, workshops, seminars, and e-learning initiatives, are employed to disseminate industry-specific knowledge and skills. Tailoring training material to align with organizational objectives and employee needs is essential for optimizing the effectiveness of these initiatives. The study's findings reveal a significant correlation between efficient human resources practices and higher levels of employee retention. Well-designed HR strategies positively impact employee engagement, job satisfaction, and commitment, ultimately leading to decreased turnover rates. Employee retention is acknowledged to have a positive impact on productivity and the overall competitiveness of organizations operating within the automobile industry. Several recommendations emerge from the study to improve human resources practices and enhance organizational performance. These include diversifying recruitment channels, enhancing employer branding efforts, and incorporating e-learning into training initiatives. The importance of fostering a culture of continuous learning, acknowledging employee accomplishments, and providing avenues for professional development is also emphasized as crucial. It is crucial to recognize the limitations of this research, including a restricted sample size and the specific context of the automotive sector in Bangladesh during the study period. Further investigation is suggested to explore enduring effects and involve a more extensive population sample to enhance the generalizability of the findings. In conclusion, implementing the recommended strategies enables automobile companies to attract and retain highly skilled individuals, create a positive work environment, and instill a sense of loyalty among employees, fostering sustainable growth and success in Bangladesh's competitive automotive industry.
Precise and Robust Sidewalk Detection: Leveraging Ensemble Learning to Surpass LLM Limitations in Urban Environments
Authors: Shihab Ibne Farabi , Alvee Benjir Islam , Bhagat Sudesh Ramesh , Sharma Anuj
Published: December 2023

The study demonstrates the effectiveness of a robust ensemble model specifically designed for accurate sidewalk detection - a crucial aspect of road safety and urban planning. The model's performance was evaluated on Cityscapes, Ade20k, and the Boston Dataset. The results indicate that the ensemble model surpasses the individual models, achieving mIOU scores of 93.1\%, 90.3\%, and 90.6\% on these datasets under ideal conditions. Furthermore, the ensemble model displayed consistent performance levels, even under challenging conditions, with a gradual decrease in efficiency observed only in various noise types such as Salt-and-Pepper and Speckle. In contrast, despite its slight advantage in ideal scenarios, the state-of-the-art ONE-PEACE Large Language Model (LLM) showed a notable drop in performance in noisy environments. These findings highlight the robustness and dependability of the ensemble model, making it a promising tool for enhancing road safety and managing curb space in complex urban environments.
Effects of ion source etching on the impedance performances of quartz component
Authors: Yang Chih-Fu F. , Chang Chih-Tsung , Tsai Yuan-Nan , Lin Chih-Lung , Hsu Chun-Yao
Published: December 2023

Quartz element (i.e., active quartz crystal oscillator or resonator) is coated on the quartz crystal with an Ag/Ni double-layer film. An ion source etching system is used to etch the Ag film surface of the quartz crystal through masks of different sizes. Three groups of masks were adopted for quartz crystal etching, the sizes of which are A (1.30×1.10 mm2), B (1.70×1.30 mm2), and C (2.42×1.62 mm2) with the remaining area not being etched. During the etching process, a frequency counter was connected to monitor the load resonance frequency (FL, MHz), load resonant frequency difference (FLD, ppm), resistance at series resonant frequency (RR, Ω, related to impedance performance). After ion source etching, the quartz element (mask A) corresponds to FLD (-385.5 ~ -256.8 ppm), and load resonant impedance RR ranges from 8.7 to 9.1 Ω, representing a 6.32% average impedance reduction. Using masks C, the quartz element corresponds to FLD (-282.9 ~ -241.1 ppm), and load resonant impedance RR ranges from 10.0 to 21.1 Ω. The average impedance divergence is 13.04 Ω. It is speculated that the size of the etching area of the quartz crystal using mask B or mask C was too large, and some remaining zones have been etched improperly, which led to an increase in impedance and also caused crystal frequency instability or oscillation failure. Precise etching and mask selection when producing quartz components is essential to maintain their functionality and stability.
High expression of COX-2 and MDR1 implicate resistance development to imatinib therapy in chronic myeloid leukemia patients
Authors: Dharmapuri Gangappa , Aribandi Anil , Kalle Arunasree M
Published: December 2023

Unresponsiveness of the chronic myeloid leukemia (CML) patients to frontline therapy of imatinib results in either dose escalation or change of drug leading to increased toxicity and financial burden. We have previously demonstrated cyclooxygenase-2 (COX-2)-dependent expression of efflux pumps via Wnt-signalling pathway as the underlying mechanism of imatinib resistance in vitro in K562 cells. The present study aimed at evaluating the gene expression of COX-2 and 3 of the efflux pumps, MDR1, MRP1and ABCG2, in lymphocytes of CML patients (n = 50) treated with different doses of imatinib as a means to diagnose resistance development. The results clearly indicated that the dosage of imatinib treatment correlated with expression levels of of efflux pumps and the COX-2-GSK3β- β-catenin-LEF signaling molecules. Although further studies are warrented, the results indicate the predictive therapeutic biomarker value of COX-2 and MDR1 during follow-up visits for early diagosis of resistance development.
Birth-pulse models to assess the effects of Wolbachia-carrying mosquito releases on the control of dengue fever
Authors: Zhang Xianghong , Li Juan , Liu Xianning
Published: December 2023

Dengue fever as a mosquito-borne disease caused by dengue virus is responsible for a substantial disease burden to the world.Wolbachia as an innovative technique has been approved to inhibit the replication of dengue viruses in mosquitoes or reduce the number of wild mosquitoes. We firstly build a birth-pulse model with sex structures to depict the nonlinear dynamics of mosquito population and then to investigate how Wolbachia can supress or replace wild mosquitoes. The existence and stability of periodic solutions of the system are proved by analyzing its stroboscopic map. Theoretical results show that under complete maternal transmission, Wolbachia will successfully establish and completely replace wild mosquitoes. Under incomplete maternal transmission, there may be two pairs of bistable periodic solutions, including the coexistence of replacement failure and partial replacement periodic solutions, or the coexistence of replacement failure and mosquito eradication periodic solutions. For these bistable situations, if the initial proportion of Wolbachia-carrying mosquitoes is greater than the critical threshold, then the strategy of partial replacement or mosquito eradication can be succeeded. Since the initial proportion of Wolbachia mosquitoes is not always greater enough in the field, we introduce mosquito releases into the birth-pulse model, and obtain the condition for the stability of complete replacement periodic solution. Finally, we give rich numerical simulations to show the multiple attractors of the systems, the comparison of three common release strategies and the effects of Wolbachia-induced parameters on control strategies. At last section, we summarize some key suggestions on the control of mosquitoes and dengue fever in practice. This work will be helpful for public health authorities in designing proper release strategies to control the spread of dengue fever.
Selective Differential Pulse Voltammetry Determination of Uric Acid in Clinical Urine Samples Using Copper Oxide Nanoparticles Modified Pencil Graphite Electrodes
Authors: Hirbo Hirbo Geremew , Kuse Kenenisa Abdisa , Hola Roba Nebi
Published: December 2023

The level of uric acid (UA) in clinical samples serves as a useful test in the diagnosis of related health disorders such as gout, hypertension & cardiovascular diseases, sclerosis, Alzheimer’s disease & optic neuritis. Interference by coexisting components of physiological fluids is a key problem to solve while attempting to demonstrate electrochemical determination of UA. CuO NPs was synthesized by aqueous chemical growth method. The deposition of the synthesized NPs on the pretreated PGE surface was carried out by drop casting of a suspension of the NPs. The current response of uric acid detection was improved by a factor of 2.63 in differential pulse voltammetric measurement compared to unmodified electrode. Under the optimized method and solution parameters, linear dependence of peak current on uric acid concentration in a wide range of 1.21x10 − 6 M to 1.142x10− 4 M, Limit of detection 6.25x10− 7 M, and limit of quantification 2.084 x10− 6 M, and excellent recovery results (90.0-99.3%) respectively. The developed sensor displayed well separated and discerned peaks for UA in presence of the potential interferent (ascorbic acid and tartaric acid). The electrode was successfully applied for the detection of UA in clinical urine samples in a phosphate buffer solution (pH = 7). The proposed sensor showed a very high reproducibility and repeatability with the relative standard deviation of 0.94%. In conclusion, a simple and low cost sensor based on PGEs is developed for sensitive and selective detection of uric acid in clinical urine samples.
Modulation of growth and chemical element accumulation in Fragaria × ananassa plants in vivo under the effect of silicon chelates
Authors: Ambros E. V. , Krupovich E. S. , Kolmogorov Yu. P. , Trofimova E. G. , Gusev I. S. , Goldenberg B. G.
Published: December 2023

Due to the protective role played by silicon in plants against unfavorable environmental conditions, siliconcontaining preparations are of considerable interest as biostimulants. In this work, a mechanical composite of rice husk and green tea containing soluble silica chelate complexes was used as the source of silicon. The study aims to examine the effect of silicon chelates on the growth and physiological parameters and the chemical composition of Fragaria × ananassa plants (Solnechnaya Polyanka variety) under greenhouse conditions. The plants were watered using water without a mechanical composite (control) or an aqueous solution containing 0.3 g/L of mechanical composite twice per period. Sampling was carried out one week after the last treatment. In order to determine the concentration of chemical elements (Si, P, S, Cl, K, Ca, Ti, Mn, Fe, Ni, Cu, Zn, Br, Rb, Sr, and Mo) in the roots and shoots of garden strawberry, it was proposed to use synchrotron X-ray fluorescence analysis. The use of the mechanical composite was shown to increase the amount of chlorophyll a, chlorophylls a and b, and carotenoids; decrease the amount of hydrogen peroxide; and increase the activity of the main antioxidant enzymes (superoxide dismutase, catalase, and peroxidase). It was determined that under the effect of the preparation, silicon accumulates primarily in shoots, affecting the accumulation of micro- and macroelements in the shoots and roots of plants. The obtained results substantiate the use of silicon-containing “green chemistry” as a means of controlling the growth and development of garden strawberry plants under in vivo conditions.
Effect of water stress on the accumulation of dehydrins in callus culture cells from Pinus sylvestris L.
Authors: Korotaeva N. E. , Shmakov V. N. , Moldavskaya S. E.
Published: December 2023

Intraspecific differences in the level of stress tolerance in woody plants remain understudied, even though this characteristic is important for tree breeding. Dehydrins are intracellular defense proteins that protect other proteins, as well as membranes, from damage caused by intracellular dehydration under water stress. The present paper aims to examine the possibility of detecting dehydrins produced in response to water stress, as well as interindividual differences in dehydrin accumulation in Pinus sylvestris L. (Scots pine) under in vitro conditions. In this work, callus culture derived from the branch and bud tissues of two Scots pine trees (T3 and T4) was used; for these trees, quantitative and qualitative differences in the composition of dehydrins were found. Interindividual differences in callus cultures were expressed as variations in the frequency of callus formation events and callus culture growth index. With the addition of 5 or 8% polyethylene glycol to the culture medium, the effect of water stress on the callus culture was expressed in a dose-dependent decrease of water content in callus cells, as well as the accumulation of shock protein Hsp70 and dehydrins having masses of 47, 42, and 27 kDa. The composition of dehydrins and the level of their accumulation differed between calluses derived from T3 and T4, suggesting different levels of water stress tolerance in the cells of these callus cultures. The existence of such differences may provide a basis for detecting dehydrins in Scots pine produced in response to water stress.
Effect of tebuconazole and azoxystrobin on the physiological parameters of wheat seedlings and their resistance to water stress
Authors: Pobezhimova T. P. , Berezhnaya E. V. , Polyakova E. A. , Korsukova A. V. , Zabanova N. S. , Lyubushkina I. V. , Stepanov A. V. , Dorofeev N.  V. , Grabelnych O.  I.
Published: December 2023

Strobilurin and triazole class fungicides are actively used in agriculture as part of dressers to protect plants from fungal disease. In addition, they have various physiological effects on plants, including increased resistance to adverse environmental factors. The combined effect of these fungicides under water stress is understudied. The present work aims to examine the individual and combined effects of tebuconazole and azoxystrobin on the growth characteristics of wheat and its resistance to water stress. The study used winter wheat (Triticum aestivum L. ) plants grown from seeds treated with tebuconazole (2 mg/50 g seeds) and azoxystrobin (4 mg/50 g seeds) suspensions separately or together. In order to create water stress, five-day seedlings were transferred to 20% polyethylene glycol solution (PEG 6000), with stability assessed at seven and nine days. Tebuconazole was found to have a retardant effect on shoots and stimulate root growth. Azoxystrobin inhibited shoot growth and particularly root growth. When used together, tebuconazole partially reduced azoxystrobin-induced root inhibition. Azoxystrobin increased the negative effect of water stress, while tebuconazole effectively protected the root system of seedlings, partially reducing the effect of azoxystrobin. The stimulation of root growth with tebuconazolewas concluded to play an important role in providing resistance of winter wheat to water stress and to have the potential for use in agriculture.
Retansiyon Psödokistlerinin Dental Patolojiler ile İlişkisinin Radyografi ile Değerlendirilmesi
Authors: DUMANLI Didem , ŞEKER Çiğdem , GEDUK Gediz
Published: December 2023

Amaç: Retansiyon psödokistleri radyografilerde sinüs sınırlarında, etrafında kortikal sınırı bulunmayan, kubbe veya yuvarlak radyoopasitelerdir. Maksiller sinüsler dişlerle yakın komşuluktadır, bundan kaynaklı retansiyon psödokistinin etyolojisine dental patolojilerin etki edebileceği düşünülmektedir. Bu çalışmada, panoramik radyografilerde retansiyon psödokistlerinin görülme sıklığının yaşa, cinsiyete ve lokalizasyonuna göre dağılımının ve prevalansının araştırılması; dental patolojilerle ilişkisinin değerlendirilmesi amaçlandı.

Gereç ve Yöntemler: 2021-2022 yıllarında yaşları15-80 aralığında 991’i kadın 1009’u erkek toplam 2000 hastanın panoramik radyografisi kullanıldı. Radyografiler; hastaların yaşı, cinsiyeti, sağ, sol ve her iki taraftaki maksiller sinüste retansiyon psödokisti bulunması ve retansiyon psödokistlerinin dental patolojilerle ilişkisi yönünden değerlendirildi.

Bulgular: 94 (% 4.7) hastada retansiyon psödokisti tespit edildi. Retansiyon psödokistlerinin 41(%2.05)’i sağ, 42 (% 2.1)’si sol ve 11(%0.55)’i her iki tarafta da gözlemlendi. Apikal lezyon (% 24.5) ve derin dentin çürüğü (% 13.8) bulunan dişlerde tek taraflı retansiyon psödokisti görülme olasılığı anlamlı bir şekilde daha yüksek bulundu. Çalışmaya dahil edilen hastalarda yaş ile lezyon varlığı ve lezyon varlığının cinsiyet ile olan ilişkisine bakıldığında istatistiksel olarak anlamlı bir sonuç bulunmadı. (p > 0.05)

Sonuç: Diş hekimleri retansiyon psödokistlerinin dental patolojilerle özellikle de derin dentin çürüğü ve apikal lezyonu olan dişlerle ilişkili olabileceğiyle ilgili bilgi sahibi olmalıdır.
Planlı Davranış Kuramı Çerçevesinde Yerel Kahve Deneyiminin Tüketim, Satın Alma ve Tavsiye Etme Niyetine Etkisi (The Impact of Local Coffee Experience on Consumption, Purchase, and Recommendation Intention within the Theory of Planned Behaviour)
Authors: YILMAZ Gökhan
Published: December 2023

Bu çalışmada planlı davranış kuramı çerçevesinde tüketicilerin yerel kahve deneyiminin tüketim, satın alma ve tavsiye etme niyetine etkisinin tespit edilmesi amaçlanmaktadır. Nicel yöntem çerçevesinde ilişkisel tarama modeli ve nedensel araştırma yaklaşımından yararlanılmaktadır. Çalışmada olasılığa dayalı olmayan örnekleme yöntemlerinden amaçlı ve kolayda örnekleme teknikleri bir arada kullanılmaktadır. Veri toplama tekniği olarak anket yönteminden yararlanılmış ve soru formları, dağıt-topla tekniği kapsamında Adıyaman Merkez ilçesinde çarşı ve üniversite bölgesinde 21 Ocak - 4 Şubat 2023 tarihlerinde saat 11.00-20.00 arasında dört anketör aracılığıyla uygulanmıştır. Dağıtılan 471 soru formundan 436 adet geri toplanmış (cevaplanma oranı= % 92,5) ve uç değerlerin çıkarılması sonucu 402 veri ile analize devam edilmiştir. Doğrulayıcı faktör analizi ile ölçüm modelinin geçerliği ve güvenirliği sağlandıktan sonra yapısal modelde yer alan dokuz hipotez test edilmiştir. Elde edilen bulgulara göre tutum ve algılanan davranışsal kontrol ile kısmen de olsa öznel normların yerel kahve deneyimine ilişkin davranışsal niyetleri (tüketim, satın alma ve tavsiye etme) etkilediği görülmektedir. Çalışmanın sonunda teorik ve pratik açıdan öneriler sunulmaktadır.
Tourism Efficiency: Bootstrap-Data Envelopment and Tobit Panel Data Analysis
Authors: GÜNEY Güven , TOPÇUOĞLU Özlem , BOZKURT Eda
Published: December 2023

Tourism is an important sector for countries, not only for cultural but also for economic activities. The tourism sector, which operates effectively, contributes to the development of the country's economy. Therefore, the study aims at calculating tourism efficiency and identifying factors that influence it. The study discussed 18 European countries that are among the world's major destination centers. Firstly, tourism efficiency scores were calculated with the data covering the period 2002-2019. Inputs are the number of tourists and tourism expenditures, and output is tourism revenues. Tourism sector efficiency was calculated with the standard Data Envelopment Analysis (DEA) model. Because of the possible statistical limitations of the DEA method, analysis was repeated with the Bootstrap-DEA method. The resulting efficiency scores were used as dependent variables in the Tobit model. The variables including per capita income, digitalization, energy consumption, financial development, political stability, and life expectancy at birth were handled as new trends of tourism efficiency in the Tobit panel data analysis. Boostrap DEA results, which yield more accurate results, gave efficiency results for a smaller number of countries than the efficiency analysis performed with standard DEA. Tobit panel data analysis results showed that income per capita, digitalization, political stability, and life expectancy at birth enhanced tourism efficiency. In the study, unlike the literature, tourism efficiency was not considered at the level of companies, but at the level of countries. In addition to the standard DEA analysis, the Bootstrap DEA method was used, which yielded superior results. Additionally, not only the efficiency values were calculated in the study, but also the factors affecting the tourism efficiency were determined.
Sosyal Medyanın Kış Turizmi Destinasyonlarının Tanıtımında Yeri ve Önemi: Çambaşı Kayak Merkezi Örneği (The Role and Importance of Social Media in the Promotion of Winter Tourism Destinations: The Example of Çambaşı Ski Resort)
Authors: KARA Emrah , ATAK Onur , ÇEKEN Hüseyin
Published: December 2023

Günümüzde sosyal medya, insanların içerik paylaştığı ve dünyanın farklı yerleri ile iletişim kurduğu önemli bir etkileşim aracıdır. Sosyal medya, iletişimden bilgi edinmeye, eğlenceden iş dünyasına, eğitimden sanata, bilimden sağlığa ve tanıtımdan pazarlamaya kadar birçok alanda kullanılmaktadır. Pazarlama faaliyetlerinin yürütülmesinde önemli bir rol oynayan sosyal medya, turizm sektöründe de yaygın bir şekilde kullanılmaktadır. Kış turizmi çerçevesinde ise günümüzde ön plana çıkan en önemli pazar bölümlerinden biri kış sporları pazarıdır. Bu bağlamda bu araştırmanın temel amacı, kış turizmi kapsamında ön plana çıkan destinasyonların tanıtımında sosyal medyanın ne düzeyde kullanıldığını belirlemek ve etkin kullanımına yönelik öneriler geliştirmektir. Bu doğrultuda Ordu Çambaşı Kayak Merkezi’nin sosyal medya pazarlamasında zayıf ve güçlü yönlerini tespit etmek amacıyla 22.01.2019 ile 11.03.2022 tarihleri arasında Instagram’da paylaşılan Ordu Çambaşı Kayak Merkezi’ne ait görseller, videolar vb. 305 sosyal medya içeriği incelenmiş, betimsel ve içerik analizi yöntemleri kullanılarak analiz edilmiştir. Bulgular sonucunda Instagram uygulamasının, Çambaşı Kayak Merkezi tarafından sıklıkla yapılan paylaşımlarla düzenli olarak kullanıldığı ve uygulama aracılığıyla ziyaretçi çekilmeye çalışıldığı tespit edilmiştir.
Glamping İşletmeleri Ziyaretçi Yorumlarının İçerik Analizi: Tripadvisor Türkiye Örneği (Content Analysis of Glamping Establishments Visitor Reviews: The Example of Tripadvisor Türkiye)
Authors: ADAN GÖK Özge , ÇAVDIRLI Ceren Miral , ALKAN Ceylan
Published: December 2023

Günümüzde sürdürülebilirlik ve sürdürülebilir turizm anlayışı hem işletmeler hem de tüketiciler açısından önem kazanmaktadır. Turistlerin doğal yaşamın içinde çevre dostu turistik işletmelere yönelmeleri, alternatif konaklama işletmelerinden biri olan glamping konaklama işletmelerinin de gelişmesine neden olmuştur. Turistler seyahatlerinde doğa ile iç içe olan alternatif konaklama olanaklarını tercih ederken hizmet kalitesine de dikkat etmektedirler. Bu araştırma Türkiye’de bulunan glamping işletmelerinde konaklayan kişilerin hizmet algılarında glamping işletmelerinin hangi özelliklerini ön plana aldıklarını belirlemek amacı ile gerçekleştirilmiştir. Bu amaca yönelik olarak Tripadvisor sitesinde Türkiye’de bulunan glamping işletmelerinin toplam 519 ziyaretçi yorumuna yönelik içerik analizi uygulanmıştır. İçerik analizi MAXQDA 2020 programı kullanılarak gerçekleştirilmiştir. Araştırma sonuçlarına göre toplam 1945 kodlama gerçekleştirilmiştir. Araştırma sonucunda tesis somut olanakları (yiyecek-içecek olanakları, temizlik/hijyen, tesis fiziksel konaklama olanakları, tesis içi olanaklar/ çevre düzenlemesi, tesis konsepti/dekorasyon), tesis soyut olanakları (hizmet kalitesi, sakinlik/huzur, misafirperverlik, fiyat-kalite dengesi, konfor, tesis atmosferi/ortam, güvenlik), tesis işletme anlayışı (alternatif etkinlikler, aile ve çocuk dostu otel, hayvan dostu otel, tesis içi indirimler/fiyata dahil olan hizmetler, sürdürülebilir turizm uygulamaları/çevresel duyarlılık) ve çevresel olanaklar (tesisin doğal çevresi/konumu, ulaşılabilirlik) olmak üzere dört ana kod ve bunlara ait on dokuz alt kod belirlenmiştir.
Design of a Configurable 4-Channel Analog Front-End for EEG Signal Acquisition on 180nm CMOS Process
Authors: Le Duc Hung , Pham The-Hung , Pham Cong-Kha
Published: December 2023

In this work, a 4-channel Analog Front-End (AFE) circuit has been proposed for EEG signal recording. For EEG recording systems, the AFE may handle a wide range of sensor inputs with high input impedance, adjustable gain, low noise, and wide bandwidth. The buffer or current-to-voltage converter block (BCV), which can be set to operate as a buffer or a current-to-voltage converter circuit, is positioned between the electrode and the main amplifier stages of the AFE to achieve high input impedance and work with sensor signal types. A chopper capacitively-coupled instrumentation amplifier (CCIA) is positioned after the BCV as the main amplifier stage of the AFE to reduce input-referred noise and balance the impedance of the overall AFE system. A programmable gain amplifier (PGA) is the third stage of the AFE that allows the overall gain of the AFE to be adjusted. The suggested AFE operates in a wide frequency range of 0.5 Hz to 2 kHz with a high input impedance bigger than 2TΩ, and it is constructed and simulated using a 180nm CMOS process. With the lowest 100-dB CMRR and low input-referred noise of 1.8 µVrms, the AFE can achieve low noise efficiency. EEG signals can be acquired with this AFE system, which is very useful for detecting epilepsy and seizures.
Extremophilic bacteria as biofertilizer for agricultural wheat
Authors: Faskhutdinova Elizaveta , Fotina Natalya , Neverova Olga , Golubtsova Yulia , Mudgal Gaurav , Asyakina Lyudmila , Aksenova Larisa
Published: December 2023

Wheat (Triticum L.) is a strategically important agricultural crop because its quality and yield provide food security for the population. Biological fertilizers improve the growth and development of agricultural crops. Unlike chemical ones, they have no toxic effect on people and the environment. This research assessed the positive effect of extremophilic microorganisms isolated from coal dump soils of the Kemerovo Region (Russia) on the growth and development of wheat.

The study featured bacterial isolates of Achromobacter denitrificans, Klebsiella oxytoca, and Rhizobium radiobacter, as well as their consortia in four different ratios: 1:1:1 (Consortium A), 2:1:1 (Consortium B), 1:2:1 (Consortium C), 1:1:2 (Consortium D), respectively. The beneficial effect was assessed by determining such factors as nitrogen fixation, solubilization of phosphates, potassium, and zinc, and production of gibberellic acid, siderophores, and hydrogen cyanide. The wheat samples were checked for germination, root length, and stem length.

R. radiobacter demonstrated the best nitrogen fixation properties. Consortium D, with two shares of R. radiobacter, yielded the best results for zinc solubilization. R. radiobacter proved to be the most efficient potassium solubilizer while the isolate of A. denitrificans was the best phosphate solubilizer. The largest amount of gibberellic acid belonged to K. oxytoca. Consortium C, which included two shares of this isolate, appeared to be the most effective siderophore producer. All samples but A. denitrificans were able to produce hydrogen cyanide. The best seed germination rate (84%) belonged to Consortium C, which contained a double share of K. oxytoca. Consortia C and B (two shares of A. denitrificans) had the greatest positive effect on the root length.

Treatment with Consortium B resulted in the longest average stem length. Extremophilic microorganisms isolated from coal dump soils of the Kemerovo Region (Russia) had a good potential as biofertilizers that could improve wheat quality and local food security.
Tencel Kumaşa Uygulanan Farklı Boyama Yöntemlerinin Seçilmiş Kumaş Performans Özelliklerine Etkisinin Değerlendirilmesi
Authors: AKBULUT Mehmet , DOBA KADEM Füsun , OĞULATA R. Tuğrul
Published: December 2023

Tencel kumaşlar genellikle dış giyimde, ev tekstili ve dekorasyon ürünlerinde kullanılmakta, çevre dostu bir lif olması nedeniyle son yıllarda önemi gittikçe artmaktadır. Literatürde farklı boyama yöntemleri ile boyanan tencel kumaşlarda yapılan araştırmalar incelendiğinde farklı performans gösterdiği tespit edilmiştir. Bu çalışmada, %100 Tencel™ Lyocell hammaddesinden üretilen kumaş, işletme şartlarında dokunmuş ve jet boyama, e-kontrol boyama ve ön terbiye sonrası pad kesikli boyama olmak üzere 3 farklı yöntemle boyanmıştır. İşlem sonrasında boyalı kumaşların tuşesi Airo 24 makinesinde iyileştirilmiştir. Boyama sonrası kumaşlarda boncuklanma, yıkamadan sonrası boyut değişimi, pH tayini, yıkama haslığı, kopma ve yırtılma mukavemeti, kumaş sertliği gibi testler standartlara uygun olarak uygulanarak spektrofotometre ile renk değerlendirmesi yapılmıştır. Bu çalışma ile e-contol boyamanın kumaş performansı açısından uygulanmasının daha doğru olduğu sonucuna ulaşılmıştır.
Orações condicionais introduzidas por “se” e “se é que” em textos jornalísticos: variações sintáticas e textual-discursivas
Authors: Silveira Santos Aymmée , Silva Camilo Rosa
Published: December 2023

O presente artigo, fundamentado na vertente Funcional Norte-Americana (GIVÓN, 1990; 1995; BYBEE, 2016), tem como objetivo identificar e descrever os diferentes usos e sentidos que emolduram as orações adverbiais condicionais encabeçadas pelos conectores se e se é que. Para isso, foram elencados três critérios de investigação: i) a posição ocupada pelo conector e, consequentemente, pelas orações adverbiais condicionais; ii) a correlação modo-temporal da oração hipotática, sinalizando diferentes graus de hipoteticidade, e iii) os gêneros textuais-discursivos em que as orações condicionais são utilizadas, tomando como base os princípios da iconicidade e da marcação. Os dados de análise provieram de textos jornalísticos coletados no banco de dados Corpus do Português, contemplando os gêneros reportagem, entrevista, comentário de leitor e artigo. O estudo demonstrou que os propósitos comunicativos imbuídos nos diversos contextos de uso da língua reverberam variações de usos e sentidos das orações condicionais, influenciando diretamente na posição sintática em que aparecem. Ainda, determinados tempos verbais, como os que foram observados nos dados, atuam como recursos requisitados pelos contextos/gêneros jornalísticos nos quais se codificam orações condicionais encabeçadas pelos conectores, indicando maior ou menor grau de complexidade estrutural e cognitiva.
Teoria política e democracia no Brasil
Authors: Rezende Dannyel Brunno Herculano
Published: December 2023

O artigo expõe as noções de democracia representativa e esfera pública (habermasiana) a partir da teorização sobre democracia e representação política. Parte da concepção de democracia grega para alcançar o arcabouço institucional da democracia representativa e deliberativa. A teoria política desenvolvida também realça a concepção liberal de democracia brasileira e o espaço vigente da esfera pública. Tais noções desdobram-se até atingir o questionamento da laicidade do Estado, que amplia a problematização da democracia liberal, em face de desafios presentes ao enfrentamento de liberdades religiosas e valores comuns da cidadania. O debate acentua a relevância acerca da reflexão permanente em torno da democracia, do arranjo institucional e suas particularidades, bastante questionadas nos dias atuais. Em sua maior parte, recorre-se aos referenciais bibliográficos já consolidados na área, quais sejam: Miguel (2003; 2014; 2017), Miguel e Biroli (2014), Manin (1995), Dahl (1997), Habermas (2014; 1997), entre outros.
O desafio de Durkheim
Authors: Morato de Andrade Otávio
Published: December 2023

O Suicídio (Le Suicide), publicado em 1897, é um marco da Sociologia, porque é com esta obra que Émile Durkheim (1858-1917) se propõe a delimitar e perquirir um fato social de acordo com o método sociológico. O presente artigo revisita este livro emblemático, por meio de uma exploração teórica, de aprofundamento conceitual, com uma abordagem qualitativa em cotejo com outras bibliografias pertinentes. Conclui-se que O Suicídio continua a ser um texto seminal, contribuindo para o legado duradouro de Durkheim na sociologia, fornecendo uma base sólida para a compreensão das dinâmicas sociais e reforçando a importância do método sociológico na análise de fenômenos complexos.