bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effects of Lighting Problems on Eye Symptoms among Cleanroom Microscope Workers
Authors: Lin Kuan-Han , Su Chien-Chia , Chen Yen-Yuan , Chu Po-Ching
Published: January 2019

The visual health of microscope workers is an important occupational health concern, and a previous study suggested an association between lighting problems (e.g., flashing light, insufficient lighting) and eye symptoms among cleanroom workers in the electronics industry. This study aimed to explore the association between eye symptoms and lighting problems, as well as light-related counteracting behaviors among microscope workers in the cleanroom environment. Ninety-one cleanroom workers aged 20 years or older were recruited from an electronics factory. The socio-demographic factors, work-related factors, eye symptoms, and lighting problems were assessed using a self-administered questionnaire. There were 92.3% female participants in this study. Among all participants, 41.8% and 63.7% had symptoms of dry eye and eye fatigue, respectively. The counteracting behaviors of needing to move closer (adjusted odds ratio (aOR) = 3.47, 95% CI = 1.11 to 10.88) was significantly associated with dry eye symptoms. Workers who were more experienced at the job (aOR = 1.03, 95% CI = 1.01 to 1.06) and had shorter break times (aOR = 0.94, 95% CI = 0.91 to 0.98) were more likely to have eye fatigue. As a result of these findings, this study suggests that good lighting and adequate break times are crucial to improve the visual health of cleanroom microscope workers.
Urban Growth-Oriented Green Accumulation: Ecological Conservation Planning in the Shenzhen DaPeng Peninsula in Southern China
Authors: Lin Dan
Published: January 2019

Neoliberal conservation has recently become a topic of academic research and a method of practice within the context of globalization. Less attention has been given to how neoliberal conservation has been practiced at the urban scale. This paper draws on the concept of ‘urban-growth-oriented green grabbing’ to capture the multidimensionality of the reasoning and process of ecological conservation in an urban growth context. It focuses on two ecological spatial protection plans for the DaPeng Peninsula in the city of Shenzhen, China. Through empirical investigation, this article traces the political economy of these plans and draws out the insights they offer regarding theories of urban environmentalism. The empirical results show that the ecological conservation plans are best understood as ‘green grabbing’ that has been achieved by land transfer and spatial interest redistribution. Conceptually, the paper provides further evidence of the process of neoliberal conservation within the urban context.
Engagement, Passion and Meaning of Work as Modulating Variables in Nursing: A Theoretical Analysis
Authors: Gómez-Salgado Juan , Navarro-Abal Yolanda , López-López María José , Romero-Martín Macarena , Climent-Rodríguez José Antonio
Published: January 2019

Nurses are continuously exposed to stressors and psychological and physical risks that can negatively influence their daily work. These adverse psychosocial circumstances, accompanied by the poor self-perception of health, well-being, and quality of life, may trigger burnout. The positive psychology approach pursues a growth of passion at work, increased job satisfaction, and occupational health, both mental and physical, for the optimal performance of the nursing role. In this way, a theoretical analysis was conducted to describe the basic constructs of positive psychology, elements such as engagement, passion at work, centrality, and meaning of work, which could act as protective factors in the nursing profession. The results show that if health professionals are not physically involved, cognitively alert, and emotionally connected, they may not offer the quality care patients require. Positive psychology helps nurses in facing their complex reality and relevant daily activities in order to provide quality care. These efforts towards a humanist nursing care in which professionals are able to care for the others as well as themselves should be made.
Diagnosis of HELLP Syndrome: A 10-Year Survey in a Perinatology Centre
Authors: Rimaitis Kestutis , Grauslyte Lina , Zavackiene Asta , Baliuliene Vilda , Nadisauskiene Ruta , Macas Andrius
Published: January 2019

HELLP (Hemolysis, Elevated Liver enzymes, Low Platelet count) syndrome is a severe and rapidly progressing condition that requires distinct diagnostic considerations. The aim of this study was to evaluate the impact of the Mississippi triple-class system on the HELLP syndrome diagnosis, treatment, and outcomes in a perinatology centre during a 10-year period, and consider its effectiveness and necessity in everyday practice. A retrospective observational cohort study was carried out using the medical records of a tertiary perinatology centre with the diagnosis of HELLP syndrome from the period of time between 2005 and 2014. The patients who fit the HELLP syndrome diagnosis were grouped by the Mississippi triple-class system. The means of diagnosis and treatment outcomes within those groups were analysed statistically. There was insufficient statistical evidence of the blood pressure levels corresponding to the severity of patients’ condition (p > 0.05 in all of the groups). The clinical presentation varied within all of the classes, and the only objective means of diagnosis and evaluation of progression of the condition were laboratory tests. Even though HELLP syndrome is considered a hypertensive multi-organ disorder of pregnancy, the level of hypertension does not correlate to the severity of the condition; hence, the diagnosis should be based on biochemical laboratory evidence. Vigilance in suspicion and the recognition of HELLP syndrome and appropriate treatment are essential in order to ensure better maternal and neonatal outcomes.
Gulf War Illness: Unifying Hypothesis for a Continuing Health Problem
Authors: Mawson Anthony R. , Croft Ashley M.
Published: January 2019

An estimated 25%–32% of veterans of the 1991 Gulf War continue to experience multiple unexplained health problems known as Gulf War Illness (GWI). GWI encompasses chronic pain, musculoskeletal weakness, headache, fatigue, cognitive deficits, alterations in mood, and numerous multi-system complaints. Most potential exposures implicated in GWI were not well documented but included varying levels of several neurotoxicants as well as the anticholinergic drug pyridostigmine bromide (PB), which was routinely taken as prophylaxis against the nerve agent soman. While some veterans also took chloroquine as an antimalarial agent, the literature suggests an association between receipt of multiple vaccinations prior to or during the conflict (perhaps combined with other exposures), and GWI. In-theater exposures may account for any single individual veteran’s ill health but many veterans of the same era who were not deployed overseas also suffer the same or similar symptoms. The features of GWI also overlap with those of fibromyalgia, chronic fatigue syndrome and multiple chemical sensitivity, in all of which liver dysfunction has been documented, suggesting a unifying hypothesis. It is proposed that multiple vaccinations, with concurrent or subsequent exposure to PB or additional chemical insults of a liver-damaging nature, plausibly explain the pathogenesis and the observed chronicity of GWI. The suggested mechanism for GWI is thus a chemically-induced impaired liver function, with the spillage of stored vitamin A compounds (“retinoids”) into the circulation in toxic concentrations, resulting in an endogenous chronic form of hypervitaminosis A. Implications of the hypothesis are briefly reviewed.
Evaluating the Effectiveness of the Health Management Program for the Elderly on Health-Related Quality of Life among Elderly People in China: Findings from the China Health and Retirement Longitudinal Study
Authors: Hao Xiuqi , Yang Yuehan , Gao Xiaotong , Dai Tao
Published: January 2019

The world’s rapidly aging population brings serious challenges which could be addressed by changes in behaviour and policy that promote good health in older age. However, these cheap and simple interventions are not available in many countries. China is one of the fastest-ageing countries in the world. The health management programs for the elderly in basic public health services was introduced by the government to promote the health of the elderly in China and address the challenges related to ageing. However, the effectiveness of the program is uncertain. So, we use a propensity score matching difference-in-difference (PSM-DID) model to analyse the causal effect of the health management program for the elderly in basic public health services on the health-related quality of life (HRQoL) of the elderly in China. The result shows that the program has improved the physical health of the elderly but has had no significant impact on mental health. Expanding the program to cover mental health could further benefit the HRQoL of the elderly. The program is a cost-effective approach to tackle the challenges of ageing and is a good example for other developing countries facing the same ageing challenges.
Analyzing Mega City-Regions through Integrating Urbanization and Eco-Environment Systems: A Case Study of the Beijing-Tianjin-Hebei Region
Authors: Tian Li , Xu Gaofeng , Fan Chenjing , Zhang Yue , Gu Chaolin , Zhang Yang
Published: January 2019

The high-speed economic growth of mega city-regions in China has been characterized by rapid urbanization accompanied by a series of environmental issues ranging from widespread soil contamination to groundwater depletion. This article begins with an analysis of the interaction between urbanization and the ecological system and reviews existing frameworks for analyzing urban and ecological systems. By taking the Beijing-Tianjin-Hebei region as an example, the article introduces a conceptual framework to analyze mega city-regions and forecast possible interactions between urbanization and eco-environment by applying simulation model. The proposed framework and its components can provide guidance to identify the impacts of urbanization and external forces such as globalization on eco-environment by integrating the internal and external factors, synthesize the complex components of mega city-regions in databases, understand and diagnose the casual relationship between urban policies and ecological consequences.
Socioeconomic Inequalities of Undiagnosed Diabetes in a Resource-Poor Setting: Insights from the Cross-Sectional Bangladesh Demographic and Health Survey 2011
Authors: Hasan Md. Mehedi , Tasnim Fariha , Tariqujjaman Md. , Ahmed Sayem
Published: January 2019

Diabetes mellitus is rising disproportionately but is not frequently diagnosed until complications appear, which results in adverse health consequences. We estimated the prevalence of undiagnosed diabetes among adult diabetic patients and associated socioeconomic inequalities in Bangladesh. We used nationally representative cross-sectional Bangladesh Demographic and Health Survey (BDHS) 2011 data. Among patients with diabetes, we identified undiagnosed cases as having fasting plasma glucose ≥ 7.0 mmol/L, never having taken prescribed medicine and being told by health professionals. Among 938 patients with diabetes, 53.4% remained undiagnosed. The poorest (75.9%) and rural (59.0%) patients had significantly higher undiagnosed cases than the richest (36.0%) and urban (42.5%), respectively. Multiple logistic regression analysis revealed that the likelihood of being undiagnosed was lower among patients with age ≥ 70 years vs. 35–39 years (adjusted odds ratio (AOR) = 0.35; 95% confidence interval (CI) 0.19, 0.64) and patients with higher education vs. no education (AOR = 0.36; 95% CI 0.21, 0.62). Conversely, a high level of physical activity and being in a poor socioeconomic quintile were associated with a higher risk of remaining undiagnosed for diabetes. The Concentration Index (C) also showed that undiagnosed diabetes was largely distributed among the socioeconomically worse-off group in Bangladesh (C = −0.35). Nationwide diabetes screening programs may reduce this problem in Bangladesh and other similar low-income settings.
CCAR2/DBC1 and Hsp60 Positively Regulate Expression of Survivin in Neuroblastoma Cells
Authors: Kim Wootae , Ryu Jaewook , Kim Ja-Eun
Published: January 2019

CCAR2 (cell cycle and apoptosis regulator 2) controls a variety of cellular functions; however, its main function is to regulate cell survival and cell death in response to genotoxic and metabolic stresses. Recently, we reported that CCAR2 protects cells from apoptosis following mitochondrial stress, possibly by co-operating with Hsp60. However, it is not clear how CCAR2 and Hsp60 control cell survival and death. Here, we found that depleting CCAR2 and Hsp60 downregulated expression of survivin, a member of the inhibitor of apoptosis (IAP) family. Survivin expression in neuroblastoma tissues and human cancer cell lines correlated positively with expression of CCAR2 and Hsp60. Furthermore, high expression of CCAR2, Hsp60, and survivin was associated with poor survival of neuroblastoma patients. In summary, both CCAR2 and Hsp60 are required for expression of survivin, and both promote cancer cell survival, at least in part, by maintaining survivin expression. Therefore, CCAR2, Hsp60, and survivin are candidate tumor biomarkers and prognostic markers in neuroblastomas.
GmBRC1 is a Candidate Gene for Branching in Soybean (Glycine max (L.) Merrill)
Authors: Shim Sangrea , Ha Jungmin , Kim Moon Young , Choi Man Soo , Kang Sung-Taeg , Jeong Soon-Chun , Moon Jung-Kyung , Lee Suk-Ha
Published: January 2019

Branch number is one of the main factors affecting the yield of soybean (Glycine max (L.)). In this study, we conducted a genome-wide association study combined with linkage analysis for the identification of a candidate gene controlling soybean branching. Five quantitative trait nucleotides (QTNs) were associated with branch numbers in a soybean core collection. Among these QTNs, a linkage disequilibrium (LD) block qtnBR6-1 spanning 20 genes was found to overlap a previously identified major quantitative trait locus qBR6-1. To validate and narrow down qtnBR6-1, we developed a set of near-isogenic lines (NILs) harboring high-branching (HB) and low-branching (LB) alleles of qBR6-1, with 99.96% isogenicity and different branch numbers. A cluster of single nucleotide polymorphisms (SNPs) segregating between NIL-HB and NIL-LB was located within the qtnBR6-1 LD block. Among the five genes showing differential expression between NIL-HB and NIL-LB, BRANCHED1 (BRC1; Glyma.06G210600) was down-regulated in the shoot apex of NIL-HB, and one missense mutation and two SNPs upstream of BRC1 were associated with branch numbers in 59 additional soybean accessions. BRC1 encodes TEOSINTE-BRANCHED1/CYCLOIDEA/PROLIFERATING CELL FACTORS 1 and 2 transcription factor and functions as a regulatory repressor of branching. On the basis of these results, we propose BRC1 as a candidate gene for branching in soybean.
Living in Promiscuity: The Multiple Partners of Alpha-Synuclein at the Synapse in Physiology and Pathology
Authors: Longhena Francesca , Faustini Gaia , Spillantini Maria Grazia , Bellucci Arianna
Published: January 2019

Alpha-synuclein (α-syn) is a small protein that, in neurons, localizes predominantly to presynaptic terminals. Due to elevated conformational plasticity, which can be affected by environmental factors, in addition to undergoing disorder-to-order transition upon interaction with different interactants, α-syn is counted among the intrinsically disordered proteins (IDPs) family. As with many other IDPs, α-syn is considered a hub protein. This function is particularly relevant at synaptic sites, where α-syn is abundant and interacts with many partners, such as monoamine transporters, cytoskeletal components, lipid membranes, chaperones and synaptic vesicles (SV)-associated proteins. These protein–protein and protein–lipid membrane interactions are crucial for synaptic functional homeostasis, and alterations in α-syn can cause disruption of this complex network, and thus a failure of the synaptic machinery. Alterations of the synaptic environment or post-translational modification of α-syn can induce its misfolding, resulting in the formation of oligomers or fibrillary aggregates. These α-syn species are thought to play a pathological role in neurodegenerative disorders with α-syn deposits such as Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA), which are referred to as synucleinopathies. Here, we aim at revising the complex and promiscuous role of α-syn at synaptic terminals in order to decipher whether α-syn molecular interactants may influence its conformational state, contributing to its aggregation, or whether they are just affected by it.
Procyanidin C1 Activates the Nrf2/HO-1 Signaling Pathway to Prevent Glutamate-Induced Apoptotic HT22 Cell Death
Authors: Song Ji Hoon , Lee Hae-Jeung , Kang Ki Sung
Published: January 2019

Natural sources are very promising materials for the discovery of novel bioactive compounds with diverse pharmacological effects. In recent years, many researchers have focused on natural sources as a means to prevent neuronal cell death in neuropathological conditions. This study focused on identifying neuroprotective compounds and their underlying molecular mechanisms. Procyanidin C1 (PC-1) was isolated from grape seeds and assessed for biological effects against glutamate-induced HT22 cell death. The results showed that PC-1 strongly prevented glutamate-induced HT22 cell death. Moreover, PC-1 was also found to prevent glutamate-induced chromatin condensation and reduce the number of annexin V-positive cells indicating apoptotic cell death. Procyanidin C1 possessed a strong 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging activity and inhibited glutamate-induced accumulation of intracellular reactive oxygen species and protein carbonylation. Additionally, PC-1 mediated nuclear translocation of nuclear factor erythroid-derived 2-related factor 2 and increased the expression levels of heme oxygenase (HO-1). Inhibition of HO-1 by tin protoporphyrin, a synthetic inhibitor, reduced the protective effect of PC-1. Furthermore, PC-1 also blocked glutamate-induced phosphorylation of mitogen-activated protein kinases (MAPKs) including ERK1/2 and p38, but not JNK. This study is the first experimental report to demonstrate the neuroprotective effects of PC-1 against glutamate-induced cytotoxicity in HT22 cells. Therefore, our results suggest that PC-1, as a potent bioactive compound of grape seeds, can prevent neuronal cell death in neuropathological conditions.
First- and Second-Generation EGFR-TKIs Are All Replaced to Osimertinib in Chemo-Naive EGFR Mutation-Positive Non-Small Cell Lung Cancer?
Authors: Takeda Masayuki , Nakagawa Kazuhiko
Published: January 2019

Activating mutations of the epidermal growth factor receptor gene (EGFR) are a driving force for some lung adenocarcinomas. Several randomized phase III studies have revealed that treatment with first- or second-generation EGFR tyrosine kinase inhibitors (TKIs) results in an improved progression-free survival (PFS) compared to standard chemotherapy in chemonaive patients with advanced non–small cell lung cancer (NSCLC), selected based on the presence of EGFR mutations. Patients treated with second-generation EGFR-TKIs have also shown an improved PFS relative to those treated with first-generation EGRF-TKIs. Osimertinib is a third-generation EGFR-TKI that still irreversibly inhibits the activity of EGFR after it has acquired the secondary T790M mutation that confers resistance to first- and second-generation drugs. Its efficacy has been validated for patients whose tumors have developed T790M-mediated resistance, as well as for first-line treatment of those patients with EGFR mutation–positive NSCLC. Although there are five EGFR-TKIs (gefitinib, erlotinib, afatinib, dacomitinib, and osimertinib) currently available for the treatment of EGFR-mutated lung cancer, the optimal sequence for administration of these drugs remains to be determined. In this review, we addressed this issue with regard to maximizing the duration of the EGFR-TKI treatment.
Epithelial to Mesenchymal Transition in Human Mesothelial Cells Exposed to Asbestos Fibers: Role of TGF-β as Mediator of Malignant Mesothelioma Development or Metastasis via EMT Event
Authors: Turini Stefano , Bergandi Loredana , Gazzano Elena , Prato Mauro , Aldieri Elisabetta
Published: January 2019

Asbestos exposure increases the risk of asbestosis and malignant mesothelioma (MM). Both fibrosis and cancer have been correlated with the Epithelial to Mesenchymal Transition (EMT)—an event involved in fibrotic development and cancer progression. During EMT, epithelial cells acquire a mesenchymal phenotype by modulating some proteins. Different factors can induce EMT, but Transforming Growth Factor β (TGF-β) plays a crucial role in promoting EMT. In this work, we verified if EMT could be associated with MM development. We explored EMT in human mesothelial cells (MeT-5A) exposed to chrysotile asbestos: we demonstrated that asbestos induces EMT in MeT-5A cells by downregulating epithelial markers E-cadherin, β-catenin, and occludin, and contemporarily, by upregulating mesenchymal markers fibronectin, α-SMA, and vimentin, thus promoting EMT. In these cells, this mechanism is mediated by increased TGF-β secretion, which in turn downregulates E-cadherin and increases fibronectin. These events are reverted in the presence of TGF-β antibody, via a Small Mother Against Decapentaplegic (SMAD)-dependent pathway and its downstream effectors, such as Zinc finger protein SNAI1 (SNAIL-1), Twist-related protein (Twist), and Zinc Finger E-Box Binding Homeobox 1 (ZEB-1), which downregulate the E-cadherin gene. Since SNAIL-1, Twist, and ZEB-1 have been shown to be overexpressed in MM, these genes could be considered possible predictive or diagnostic markers of MM development.
Complete Genome Sequence and Comparative Analysis of Synechococcus sp. CS-601 (SynAce01), a Cold-Adapted Cyanobacterium from an Oligotrophic Antarctic Habitat
Authors: Tang Jie , Du Lian-Ming , Liang Yuan-Mei , Daroch Maurycy
Published: January 2019

Marine picocyanobacteria belonging to Synechococcus are major contributors to the global carbon cycle, however the genomic information of its cold-adapted members has been lacking to date. To fill this void the genome of a cold-adapted planktonic cyanobacterium Synechococcus sp. CS-601 (SynAce01) has been sequenced. The genome of the strain contains a single chromosome of approximately 2.75 MBp and GC content of 63.92%. Gene prediction yielded 2984 protein coding sequences and 44 tRNA genes. The genome contained evidence of horizontal gene transfer events during its evolution. CS-601 appears as a transport generalist with some specific adaptation to an oligotrophic marine environment. It has a broad repertoire of transporters of both inorganic and organic nutrients to survive in inhospitable environments. The cold adaptation of the strain exhibited characteristics of a psychrotroph rather than psychrophile. Its salt adaptation strategy is likely to rely on the uptake and synthesis of osmolytes, like glycerol or glycine betaine. Overall, the genome reveals two distinct patterns of adaptation to the inhospitable environment of Antarctica. Adaptation to an oligotrophic marine environment is likely due to an abundance of genes, probably acquired horizontally, that are associated with increased transport of nutrients, osmolytes, and light harvesting. On the other hand, adaptations to low temperatures are likely due to prolonged evolutionary changes.
Overexpression of the Jojoba Aquaporin Gene, ScPIP1, Enhances Drought and Salt Tolerance in Transgenic Arabidopsis
Authors: Wang Xing , Gao Fei , Bing Jie , Sun Weimin , Feng Xiuxiu , Ma Xiaofeng , Zhou Yijun , Zhang Genfa
Published: January 2019

Plasma membrane intrinsic proteins (PIPs) are a subfamily of aquaporin proteins located on plasma membranes where they facilitate the transport of water and small uncharged solutes. PIPs play an important role throughout plant development, and in response to abiotic stresses. Jojoba (Simmondsia chinensis (Link) Schneider), as a typical desert plant, tolerates drought, salinity and nutrient-poor soils. In this study, a PIP1 gene (ScPIP1) was cloned from jojoba and overexpressed in Arabidopsis thaliana. The expression of ScPIP1 at the transcriptional level was induced by polyethylene glycol (PEG) treatment. ScPIP1 overexpressed Arabidopsis plants exhibited higher germination rates, longer roots and higher survival rates compared to the wild-type plants under drought and salt stresses. The results of malonaldehyde (MDA), ion leakage (IL) and proline content measurements indicated that the improved drought and salt tolerance conferred by ScPIP1 was correlated with decreased membrane damage and improved osmotic adjustment. We assume that ScPIP1 may be applied to genetic engineering to improve plant tolerance based on the resistance effect in transgenic Arabidopsis overexpressing ScPIP1.
Overexpression of P2X3 and P2X7 Receptors and TRPV1 Channels in Adrenomedullary Chromaffin Cells in a Rat Model of Neuropathic Pain
Authors: Arribas-Blázquez Marina , Olivos-Oré Luis Alcides , Barahona María Victoria , Sánchez de la Muela Mercedes , Solar Virginia , Jiménez Esperanza , Gualix Javier , McIntosh J. Michael , Ferrer-Montiel Antonio , Miras-Portugal María Teresa , Artalejo Antonio R.
Published: January 2019

We have tested the hypothesis that neuropathic pain acting as a stressor drives functional plasticity in the sympathoadrenal system. The relation between neuropathic pain and adrenal medulla function was studied with behavioral, immunohistochemical and electrophysiological techniques in rats subjected to chronic constriction injury of the sciatic nerve. In slices of the adrenal gland from neuropathic animals, we have evidenced increased cholinergic innervation and spontaneous synaptic activity at the splanchnic nerve–chromaffin cell junction. Likewise, adrenomedullary chromaffin cells displayed enlarged acetylcholine-evoked currents with greater sensitivity to α-conotoxin RgIA, a selective blocker of α9 subunit-containing nicotinic acetylcholine receptors, as well as increased exocytosis triggered by voltage-activated Ca2+ entry. Altogether, these adaptations are expected to facilitate catecholamine output into the bloodstream. Last, but most intriguing, functional and immunohistochemical data indicate that P2X3 and P2X7 purinergic receptors and transient receptor potential vanilloid-1 (TRPV1) channels are overexpressed in chromaffin cells from neuropathic animals. These latter observations are reminiscent of molecular changes characteristic of peripheral sensitization of nociceptors following the lesion of a peripheral nerve, and suggest that similar phenomena can occur in other tissues, potentially contributing to behavioral manifestations of neuropathic pain.
Networked Euler-Lagrangian Systems Synchronization under Time-Varying Communicating Delays
Authors: Wang Hongjun , Zhao Zhuoqun , Li Tao
Published: January 2019

This paper investigates the problem of the task-space synchronization control for networked Euler-Lagrange systems. In the considered systems, there are time-varying delays existing in the networking links and every subsystem contains uncertainties in both kinematics and dynamics. By adding new time-varying coupling gains, the negative effects caused by time-varying delays are eliminated. Moreover, to address the difficulties of parametric calibration, an adaptively synchronous protocol and adaptive laws are designed to online estimate kinematics and dynamic uncertainties. Through a Lyapunov candidate and a Lyapunov-Krasovskii functional, the asymptotic convergences of tracking errors and synchronous errors are rigorously proved. The simulation results demonstrate the proposed protocol guaranteeing the cooperative tracking control of the uncalibrated networked Euler-Lagrange systems in the existence of time-varying delays.
Use of Hyperspectral/Multispectral Imaging in Gastroenterology. Shedding Some–Different–Light into the Dark
Authors: Ortega Samuel , Fabelo Himar , Iakovidis Dimitris , Koulaouzidis Anastasios , Callico Gustavo
Published: January 2019

Hyperspectral/Multispectral imaging (HSI/MSI) technologies are able to sample from tens to hundreds of spectral channels within the electromagnetic spectrum, exceeding the capabilities of human vision. These spectral techniques are based on the principle that every material has a different response (reflection and absorption) to different wavelengths. Thereby, this technology facilitates the discrimination between different materials. HSI has demonstrated good discrimination capabilities for materials in fields, for instance, remote sensing, pollution monitoring, field surveillance, food quality, agriculture, astronomy, geological mapping, and currently, also in medicine. HSI technology allows tissue observation beyond the limitations of the human eye. Moreover, many researchers are using HSI as a new diagnosis tool to analyze optical properties of tissue. Recently, HSI has shown good performance in identifying human diseases in a non-invasive manner. In this paper, we show the potential use of these technologies in the medical domain, with emphasis in the current advances in gastroenterology. The main aim of this review is to provide an overview of contemporary concepts regarding HSI technology together with state-of-art systems and applications in gastroenterology. Finally, we discuss the current limitations and upcoming trends of HSI in gastroenterology.
Early Risk Score for Predicting Hypotension in Normotensive Patients with Non-Variceal Upper Gastrointestinal Bleeding
Authors: Ko Byuk , Kim Youn-Jung , Jung Dae , Sohn Chang , Seo Dong , Lee Yoon-Seon , Lim Kyoung , Jung Hwoon-yong , Kim Won
Published: January 2019

Risk assessment for upper gastrointestinal bleeding (UGIB) is important; however, current scoring systems are insufficient. We aimed to develop and validate a prediction model for rapidly determining the occurrence of hypotension in non-variceal UGIB patients with normotension (systolic blood pressure ≥90 mmHg) at emergency department presentation. In this prospective observational cohort study, consecutive non-variceal UGIB patients between January 2012 and April 2017 were enrolled. We developed and validated a new prediction model through logistic regression, with the occurrence of hypotension <24 h as the primary outcome. Among 3363 UGIB patients, 1439 non-variceal UGIB patients were included. The risk factors for the occurrence of hypotension were lactate level, blood in nasogastric tube, and systolic blood pressure. The area under the curve (AUC) of the new scoring model (LBS—Lactate, Blood in nasogastric tube, Systolic blood pressure) in the development cohort was 0.74, higher than the value of 0.64 of the Glasgow–Blatchford score for predicting the occurrence of hypotension. The AUC of the LBS score in the validation cohort was 0.83. An LBS score of ≤2 had a negative predictive value of 99.5% and an LBS score of ≥7 had a specificity of 97.5% in the validation cohort. The new LBS score stratifies normotensive patients with non-variceal UGIB at risk for developing hypotension.
FAK is Required for Tumor Metastasis-Related Fluid Microenvironment in Triple-Negative Breast Cancer
Authors: Pan Mei-Ren , Hou Ming-Feng , Ou-Yang Fu , Wu Chun-Chieh , Chang Shu-Jyuan , Hung Wen-Chun , Yip Hon-Kan , Luo Chi-Wen
Published: January 2019

Cancer cell metastasis is the main cause of death in patients with cancer. Many studies have investigated the biochemical factors that affect metastasis; however, the role of physical factors such as fluid shear stress (FSS) in tumorigenesis and metastasis have been less investigated. Triple-negative breast cancer (TNBC) has a higher incidence of lymph node invasion and distant metastasis than other subtypes of breast cancer. In this study, we investigated the influence of FSS in regulating the malignant behavior of TNBC cells. Our data demonstrate that low FSS promotes cell migration, invasion, and drug resistance, while high FSS has the opposite results; additionally, we found that these phenomena were regulated through focal adhesion kinase (FAK). Using immunohistochemistry staining, we show that FAK levels correlate with the nodal stage and that FAK is a significant independent predictor of overall survival in patients. Altogether, these data implicate FAK as a fluid mechano-sensor that regulates the cell motility induced by FSS and provide a strong rationale for cancer treatments that combine the use of anti-cancer drugs and strategies to modulate tumor interstitial fluid flow.
IoT-Based Solid Waste Management Solutions: A Survey
Authors: Pardini Kellow , Rodrigues Joel J. P. C. , Kozlov Sergei A. , Kumar Neeraj , Furtado Vasco
Published: January 2019

With the increase of population density and the rural exodus to cities, urbanization is assuming extreme proportions and presents a tremendous urban problem related to waste generation. The increase of waste generation has been considered a significant challenge to large urban centers worldwide and represents a critical issue for countries with accelerated population growth in cities. The Internet of Things (IoT) and cloud computing offer an automation possibility through cyberphysical systems that will change the way solid waste management is performed. Considering IoT requirements, a review analysis of waste management models available in the literature is performed in detail in this paper. Then, a deep review is undertaken of the related literature based on IoT infrastructure for efficient handling of waste generated in urban scenarios, focusing on the interaction among concessionaires and waste generators (citizens) from the perspective of a shorter collection time with reduced costs, as well as citizenship promotion. An IoT-based reference model is described, and a comparison analysis of the available solutions is presented, with the goal to highlight the most relevant approaches and identify open research issues on the topic.
Model Mediation to Overcome Light Limitations—Toward a Secure Tactile Internet System
Authors: Ateya Abdelhamied A. , Muthanna Ammar , Vybornova Anastasia , Gudkova Irina , Gaidamaka Yuliya , Abuarqoub Abdelrahman , Algarni Abeer D. , Koucheryavy Andrey
Published: January 2019

Enabling haptic communication as well as voice and data over the future 5G cellular system has become a demand. Tactile Internet is one of the main use cases of the 5G system that will allow the transfer of haptic communications in real time. Latency, availability, reliability, and security are the main design challenges of the tactile Internet system and haptic based bilateral teleoperation systems. An end-to-end latency of 1 ms remains the main challenge toward tactile Internet system realization, not only for the processing and coding delays but mainly for the limitations of light. In this work, we analyze the key solutions to overcome the light limitations and enable the tactile Internet over any distances with the required latency. Building a virtual model or model mediated for the remote environment at the edge cloud unit near to the end user is the main solution. By means of AI, the virtual model can predict the behavior of the remote environment and thus, the end user can interact with the virtual environment with a high system experience. This literature review covers the existing work of the model mediated bilateral teleoperated systems and discusses its availability for the tactile Internet system. Furthermore, the security issues of tactile Internet system and the effect of model mediated system on the required security level of tactile Internet applications are discussed. Finally, a structure for the tactile Internet system, with the deployment of model mediation, is suggested.
Conservation through Biocultural Heritage—Examples from Sub-Saharan Africa
Authors: Ekblom Anneli , Shoemaker Anna , Gillson Lindsey , Lane Paul , Lindholm Karl-Johan
Published: January 2019

In this paper, we review the potential of biocultural heritage in biodiversity protection and agricultural innovation in sub-Saharan Africa. We begin by defining the concept of biocultural heritage into four interlinked elements that are revealed through integrated landscape analysis. This concerns the transdisciplinary methods whereby biocultural heritage must be explored, and here we emphasise that reconstructing landscape histories and documenting local heritage values needs to be an integral part of the process. Ecosystem memories relate to the structuring of landscape heterogeneity through such activities as agroforestry and fire management. The positive linkages between living practices, biodiversity and soil nutrients examined here are demonstrative of the concept of ecosystem memories. Landscape memories refer to built or enhanced landscapes linked to specific land-use systems and property rights. Place memories signify practices of protection or use related to a specific place. Customary protection of burial sites and/or abandoned settlements, for example, is a common occurrence across Africa with beneficial outcomes for biodiversity and forest protection. Finally, we discuss stewardship and change. Building on local traditions, inclusivity and equity are essential to promoting the continuation and innovation of practices crucial for local sustainability and biodiversity protection, and also offer new avenues for collaboration in landscape management and conservation.
Erratum: Importance of Emulsification in Calibrating Infrared Spectroscopes for Analyzing Water Contamination in Used or In-Service Engine Oil. Lubricants 2018, 6, 35
Authors: Holland Torrey , Abdul-Munaim Ali , Watson Dennis , Sivakumar Poopalasingam
Published: January 2019

The authors wish to correct the affiliation of co-author Ali Mazin Abdul-Munaim in their previous paper [...]
Analogous Anti-Ferroelectricity in Y2O3-Coated (Pb0.92Sr0.05La0.02)(Zr0.7Sn0.25Ti0.05)O3 Ceramics and Their Energy-Storage Performance
Authors: Fang Bijun , Jiang Yan , Zhao Xiangyong , Zhang Shuai , Wu Dun , Ding Jianning
Published: January 2019

Antiferroelectric analogous (Pb0.92Sr0.05La0.02)(Zr0.7Sn0.25Ti0.05)O3 (PSLZSnT) ceramics were prepared by the solid-state sintering method by introducing a Y2O3-coating via the self-combustion method. The synthesized Y2O3-doped PSLZSnT ceramics present pseudo-cubic structure and rather uniform microstructural morphology accompanied by relatively small grain size. Excellent energy-storage performance is obtained in the Y2O3-doped PSLZSnT ceramics, in which the value of the energy-storage density presents a linearly increasing trend within the electric field measurement range. Such excellent performance is considered as relating to the rather pure perovskite structure, high relative density accompanied by relatively small grain size, and the antiferroelectric-like polarization-electric field behavior.
Immobilized Enzymes in Biosensor Applications
Authors: Nguyen Hoang Hiep , Lee Sun Hyeok , Lee Ui Jin , Fermin Cesar D. , Kim Moonil
Published: January 2019

Enzyme-based biosensing devices have been extensively developed over the last few decades, and have proven to be innovative techniques in the qualitative and quantitative analysis of a variety of target substrates over a wide range of applications. Distinct advantages that enzyme-based biosensors provide, such as high sensitivity and specificity, portability, cost-effectiveness, and the possibilities for miniaturization and point-of-care diagnostic testing make them more and more attractive for research focused on clinical analysis, food safety control, or disease monitoring purposes. Therefore, this review article investigates the operating principle of enzymatic biosensors utilizing electrochemical, optical, thermistor, and piezoelectric measurement techniques and their applications in the literature, as well as approaches in improving the use of enzymes for biosensors.
An Experimental Study on the Precision Abrasive Machining Process of Hard and Brittle Materials with Ultraviolet-Resin Bond Diamond Abrasive Tools
Authors: Guo Lei , Zhang Xinrong , Chen Shibin , Hui Jizhuang
Published: January 2019

Ultraviolet-curable resin was introduced as a bonding agent into the fabrication process of precision abrasive machining tools in this study, aiming to deliver a rapid, flexible, economical, and environment-friendly additive manufacturing process to replace the hot press and sintering process with thermal-curable resin. A laboratory manufacturing process was established to develop an ultraviolet-curable resin bond diamond lapping plate, the machining performance of which on the ceramic workpiece was examined through a series of comparative experiments with slurry-based iron plate lapping. The machined surface roughness and weight loss of the workpieces were periodically recorded to evaluate the surface finish quality and the material removal rate. The promising results in terms of a 12% improvement in surface roughness and 25% reduction in material removal rate were obtained from the ultraviolet-curable resin plate-involved lapping process. A summarized hypothesis was drawn to describe the dynamically-balanced state of the hybrid precision abrasive machining process integrated both the two-body and three-body abrasion mode.
Disinfectant Performance of a Chlorine Regenerable Antibacterial Microfiber Fabric as a Reusable Wiper
Authors: Huang Cheng , Chen Yongbang , Sun Gang , Yan Kelu
Published: January 2019

Rechargeable disinfectant performance of a microfiber fabric grafted with a halamine precursor, 3-allyl-5,5-dimethylhydantoin (ADMH), was tested in an actual use situation in a university student dining hall. The precursor was successfully incorporated onto the surfaces of polyester fibers by using a radical graft polymerization process through a commercial finishing facility. The N–H bonds of ADMH moieties on the fibers can be converted to biocidal N–Cl bonds, when the fabrics are washed in a diluted chlorine bleach containing 3000 ppm available chlorine, providing a refreshable disinfectant function. By wiping the surfaces of 30 tables (equivalent to 18 m2) with wet chlorinated fabrics, both Staphylococcus aureus and Escherichia coli in concentrations of 105 CFU/mL were totally killed in a contact time of 3 min. The disinfectant properties of the fabrics were still superior after 10 times successive machine washes (equivalent to fifty household machine washes), and rechargeable after wiping 30 tables before each recharge. Recharging conditions, such as temperature, time, active chlorine concentration and pH value of sodium hypochlorite solution, as well as the addition of a detergent, were studied. The product has the potential to improve public safety against biological contaminations and the transmission of diseases.
A New Phenomenological Model for Single Particle Erosion of Plastic Materials
Authors: Cheng Jiarui , Zhang Ningsheng , Wei Liang , Mi Hongxue , Dou Yihua
Published: January 2019

A phenomenological model for single particle erosion (SPE) of plastic materials was constructed based on the Hertzian contact theory and conservation of momentum to solve the particle impact erosion. The extrusion deformation and contact time of materials in three processes of wall elastic extrusion, elastic-plastic extrusion, and elastic recovery were discussed. Later, the critical angle for sliding contact between the particle and metal surface was calculated according to the impact angle of a particle and the corresponding critical sliding friction force of the particle. The wall indentation depths under sliding contact and no sliding contact were compared. Finally, the erosion volume of materials by impact of a single particle was gained. Moreover, a contrastive analysis on calculation results was carried out by using the gas-solid jet erosion experiment. Contact time, normal and tangential deformations of materials, as well as material erosion under sliding contact and no sliding contact in two processes of particle extrusion and rebound were gained from calculation and experiment. The constructed model showed a good agreement without involving too many empirical coefficients.
Magnesium Implants: Prospects and Challenges
Authors: Chakraborty Banerjee Parama , Al-Saadi Saad , Choudhary Lokesh , Harandi Shervin Eslami , Singh Raman
Published: January 2019

Owing to their suitable mechanical property and biocompatibility as well as the technological possibility of controlling their high corrosion rates, magnesium and its alloys have attracted significant attention as temporary bio-implants. Though the ability of magnesium to harmlessly biodegrade and its inherent biocompatibility make magnesium alloys a suitable choice for a temporary implant, their high corrosion rates limit their practical application, as the implants can potentially corrode away even before the healing process has completed. Different approaches, such as alloying, surface modification, and conversion coatings, have been explored to improve the corrosion resistance of various magnesium alloys. However, the corrosion behavior of magnesium implants with and without a surface modification has been generally investigated under in-vitro conditions, and studies under in-vivo conditions are limited, which has contributed to the lack of translation of magnesium implants in practical applications. This paper comprehensively reviews the prospects of magnesium alloy implants and the current challenges due to their rapid degradation in a physiological environment. This paper also provides a comprehensive review of the corrosion mitigation measures for these temporary implants.
A Coupled EBSD/TEM Analysis of the Microstructure Evolution of a Gradient Nanostructured Ferritic/Martensitic Steel Subjected to Surface Mechanical Attrition Treatment
Authors: Liu Wenbo , Jin Xiao , Zhang Bo , Yun Di , Chen Piheng
Published: January 2019

Surface mechanical attrition treatment (SMAT) was performed on a reduced ferritic/martensitic (RAFM) steel to form a nanostructured (NS) layer on the surface of the sample. Both electron backscatter diffraction (EBSD) and TEM were used to investigate the microstructure evolution during SMAT. The experimental results showed that there were three different zones after SMAT: (i) The “ultrafine grain” (UFG) zone, observed at the top-most surface region, (ii) the “transition zone” in which the original grains were fragmented under the severe plastic deformation and (iii) the “deformed zone” in which the original grains were simply deformed. The average grain sizes increased rapidly with the increase of depth, while the Vickers hardness decreased with the increase of depth, and this phenomenon could be explained in terms of boundary strengthening and dislocation strengthening. The number fractions of medium-angle grain boundaries (MAGBs) and medium-high-angle grain boundaries (MHAGBs) in UFG zones were larger than those in the transition zone and the deformed zone. However, the number fraction of the low-angle grain boundaries (LAGBs) was extremely small in all the zones after SMAT, especially in the transition zone.
Evaluation of ARIMA Models for Human–Machine Interface State Sequence Prediction
Authors: Singh Harsh V. P. , Mahmoud Qusay H.
Published: January 2019

In this paper, auto-regressive integrated moving average (ARIMA) time-series data forecast models are evaluated to ascertain their feasibility in predicting human–machine interface (HMI) state transitions, which are modeled as multivariate time-series patterns. Human–machine interface states generally include changes in their visually displayed information brought about due to both process parameter changes and user actions. This approach has wide applications in industrial controls, such as nuclear power plant control rooms and transportation industry, such as aircraft cockpits, etc., to develop non-intrusive real-time monitoring solutions for human operator situational awareness and potentially predicting human-in-the-loop error trend precursors.