bluuebunny/crossref_metadata_2025 huggingface dataset:
Answering FO+MOD Queries under Updates on Bounded Degree Databases
Authors: Berkholz Christoph , Keppeler Jens , Schweikardt Nicole
Published: August 2018

We investigate the query evaluation problem for fixed queries over fully dynamic databases, where tuples can be inserted or deleted. The task is to design a dynamic algorithm that immediately reports the new result of a fixed query after every database update.

We consider queries in first-order logic (FO) and its extension with modulo-counting quantifiers (FO+MOD) and show that they can be efficiently evaluated under updates, provided that the dynamic database does not exceed a certain degree bound.

In particular, we construct a data structure that allows us to answer a Boolean FO+MOD query and to compute the size of the result of a non-Boolean query within constant time after every database update. Furthermore, after every database update, we can update the data structure in constant time such that afterwards we are able to test within constant time for a given tuple whether or not it belongs to the query result, to enumerate all tuples in the new query result, and to enumerate the difference between the old and the new query result with constant delay between the output tuples. The preprocessing time needed to build the data structure is linear in the size of the database.

Our results extend earlier work on the evaluation of first-order queries on static databases of bounded degree and rely on an effective Hanf normal form for FO+MOD recently obtained by Heimberg, Kuske, and Schweikardt (LICS 2016).
Emotion recognition using wireless signals
Authors: Zhao Mingmin , Adib Fadel , Katabi Dina
Published: August 2018

This paper demonstrates a new technology that can infer a person's emotions from RF signals reflected off his body. EQ-Radio transmits an RF signal and analyzes its reflections off a person's body to recognize his emotional state (happy, sad, etc.). The key enabler underlying EQ-Radio is a new algorithm for extracting the individual heartbeats from the wireless signal at an accuracy comparable to on-body ECG monitors. The resulting beats are then used to compute emotion-dependent features which feed a machine-learning emotion classifier. We describe the design and implementation of EQ-Radio, and demonstrate through a user study that its emotion recognition accuracy is on par with state-of-the-art emotion recognition systems that require a person to be hooked to an ECG monitor.
It's getting real. Virtually real.
Authors: Kumar Neha , Vishwanath Aditya
Published: August 2018

This is a forum for perspectives on designing for communities marginalized by economics, social status, infrastructure, or policies. It will discuss design methods, theoretical and conceptual contributions, and methodological engagements for underserved communities.
--- Nithya Sambasivan, Editor
Robotic implants
Authors: Mone Gregory
Published: August 2018

Scientists are developing tiny medical machines that stretch the definition of the term "robot."
Skin wettedness is an important contributor to thermal behavior during exercise and recovery
Authors: Vargas Nicole T. , Chapman Christopher L. , Johnson Blair D. , Gathercole Rob , Schlader Zachary J.
Published: August 2018

We tested the hypothesis that mean skin wettedness contributes to thermal behavior to a greater extent than core and mean skin temperatures. In a 27.0 ± 1.0°C environment, 16 young participants (8 females) cycled for 30 min at 281 ± 51 W·m2, followed by 120 min of seated recovery. Mean skin and core temperatures and mean skin wettedness were recorded continuously. Participants maintained a thermally comfortable neck temperature throughout the protocol using a custom-made device. Neck device temperature provided an index of thermal behavior. Linear regression was performed using individual minute data with mean skin wettedness and core and mean skin temperatures as independent variables and neck device temperature as the dependent variable. Standarized β-coefficients were used to determine relative contributions to thermal behavior. Mean skin temperature differed from preexercise (32.6 ± 0.5°C) to 10 min into exercise (32.3 ± 0.6°C, P < 0.01). Core temperature increased from 37.1 ± 0.3°C preexercise to 37.7 ± 0.4°C by end exercise ( P < 0.01) and remained elevated through 30 min of recovery (37.2 ± 0.3°C, P < 0.01). Mean skin wettedness increased from preexercise [0.14 ± 0.03 arbitrary units (AU)] to 20 min into exercise (0.43 ± 0.09 AU, P < 0.01) and remained elevated through 80 min of recovery (0.18 ± 0.06 AU, P ≤ 0.05). Neck device temperature decreased from 26.4 ± 1.6°C preexercise to 18.5 ± 8.7°C 10 min into exercise ( P = 0.03) and remained depressed through 20 min of recovery (14.4 ± 11.2°C, P < 0.01). Mean skin wettedness (52 ± 24%) provided a greater contribution to thermal behavior compared with core (22 ± 22%, P = 0.06) and mean skin (26 ± 16%, P = 0.04) temperatures. Skin wettedness is an important contributing factor to thermal behavior during exercise and recovery.
Comparison of methods of chemical loop gain measurement during tidal ventilation in awake healthy subjects
Authors: Bokov Plamen , Matrot Boris , Gallego Jorge , Delclaux Christophe
Published: August 2018

The loop gain (LG) is defined as the ratio of a ventilatory response over the perturbation in ventilation, and it is used to analyze ventilatory control stability. The LG can be derived from minute ventilation (V̇e), end-tidal Pco2([Formula: see text]), and end-tidal Po2([Formula: see text]) values. Several methods of LG assessment have been developed, which have never been compared. We evaluated the computability, the short-term repeatability, and the agreement of six published (or slightly modified) models for LG determination. These models included three unconstrained autoregressive models, univariate (V̇e), bivariate (V̇e, [Formula: see text]), and trivariate (V̇e, [Formula: see text], and [Formula: see text]), and three analytical transfer function constrained models based on V̇e, V̇e and CO2-sensitivity, and V̇e and central and peripheral CO2sensitivities, respectively. The models were tested with tidal breathing data in 37 awake healthy subjects (median age 35 yr; 23 women, 14 men). Modeling failed in 11, 0, and 0 subjects for the three unconstrained models, respectively, and 4, 1, and 9 subjects for the three constrained models, respectively. Bland and Altman analyses of the LG values in the medium frequency range of two separate recordings demonstrated good repeatability for four models, excluding univariate and trivariate unconstrained models. The four repeatable models gave LG values that were in agreement (medium frequency LG, median 0.100–0.210), although the constrained model based on V̇e systematically overestimated LG values. The variances explained by these models were ∼20%. In conclusion, model-based analyses of tidal breathing were performed with different approaches that gave comparable results for chemical LG and explained variance.

NEW & NOTEWORTHY Several methods of chemical loop gain measurement have been published but never compared. We show that a better repeatability is obtained with analytical constrained models compared with autoregressive unconstrained models and that the repeatable models gave comparable results of loop gain, even if the calculation based on ventilation-only recording gave higher values than those obtained with both ventilation and end-tidal Pco2recording. The explained variance of ventilation was similar whatever the model.
Hemodynamic characteristics of postural hyperventilation: POTS with hyperventilation versus panic versus voluntary hyperventilation
Authors: Stewart Julian M. , Pianosi Paul , Shaban Mohamed A. , Terilli Courtney , Svistunova Maria , Visintainer Paul , Medow Marvin S.
Published: August 2018

Upright hyperventilation occurs in ~25% of our patients with postural tachycardia syndrome (POTS). Poikilocapnic hyperventilation alone causes tachycardia. Here, we examined changes in respiration and hemodynamics comprising cardiac output (CO), systemic vascular resistance (SVR), and blood pressure (BP) measured during head-up tilt (HUT) in three groups: patients with POTS and hyperventilation (POTS-HV), patients with panic disorder who hyperventilate (Panic), and healthy controls performing voluntary upright hyperpnea (Voluntary-HV). Though all were comparably tachycardic during hyperventilation, POTS-HV manifested hyperpnea, decreased CO, increased SVR, and increased BP during HUT; Panic patients showed both hyperpnea and tachypnea, increased CO, and increased SVR as BP increased during HUT; and Voluntary-HV were hyperpneic by design and had increased CO, decreased SVR, and decreased BP during upright hyperventilation. Mechanisms of hyperventilation and hemodynamic changes differed among POTS-HV, Panic, and Voluntary-HV subjects. We hypothesize that the hyperventilation in POTS is caused by a mechanism involving peripheral chemoreflex sensitization by intermittent ischemic hypoxia.

NEW & NOTEWORTHY Hyperventilation is common in postural tachycardia syndrome (POTS) and has distinctive cardiovascular characteristics when compared with hyperventilation in panic disorder or with voluntary hyperventilation. Hyperventilation in POTS is hyperpnea only, distinct from panic in which tachypnea also occurs. Cardiac output is decreased in POTS, whereas peripheral resistance and blood pressure (BP) are increased. This is distinct from voluntary hyperventilation where cardiac output is increased and resistance and BP are decreased and from panic where they are all increased.
Effects of hypoxia-ischemia and inotropes on expression of cardiac adrenoceptors in the preterm fetal sheep
Authors: Hutchinson Dana S. , Brew Nadine , Vu Teresa , Merlin Jon , Hale Nadia , Walker David W. , Wong Flora Y.
Published: August 2018

Preterm infants frequently suffer cardiovascular compromise, with hypotension and/or low systemic blood flow, leading to tissue hypoxia-ischemia (HI). Many preterm infants respond inadequately to inotropic treatments using adrenergic agonists such as dobutamine (DB) or dopamine (DA). This may be because of altered cardiac adrenoceptor expression because of tissue HI or prolonged exposure to adrenergic agonists. We assessed the effects of severe HI with and without DB/DA treatment on cardiac adrenoceptor expression in preterm fetal sheep. Fetal sheep (93–95 days) exposed to sham surgery or severe HI induced by umbilical cord occlusion received intravenous DB or saline for 74 h (HI + DB, HI, Sham + DB, Sham). The HI groups were also compared with fetal sheep exposed to HI and DA. Fetal hearts were collected to determine β-adrenoceptor numbers using [125I]-cyanopindolol binding and mRNA expression of β1-, β2-, α1A-, α2A-, or α2B-adrenoceptors. The HI group had increased β-adrenoceptor numbers compared with all other groups in all four heart chambers ( P < 0.05). This increase in β-adrenoceptor numbers in the HI group was significantly reduced by DB infusion in all four heart chambers, but DA infusion in the HI group only reduced β-adrenoceptor numbers in the left atria and ventricle. DB alone did not affect β-adrenoceptor numbers in the sham animals. Changes in β1-adrenoceptor mRNA levels trended to parallel the binding results. We conclude that HI upregulates preterm fetal cardiac β-adrenoceptors, but prolonged exposure to adrenergic agonists downregulates adrenoceptors in the preterm heart exposed to HI and may underpin the frequent failure of inotropic therapy in preterm infants.

NEW & NOTEWORTHY This is the first study, to our knowledge, on the effects of hypoxia-ischemia and adrenergic agonists on adrenoceptors in the preterm heart. In fetal sheep, we demonstrate that hypoxia-ischemia increases cardiac β-adrenoceptor numbers. However, exposure to both hypoxia-ischemia and adrenergic agonists (dobutamine or dopamine) reduces the increase in β-adrenoceptor numbers, which may underpin the inadequate response in human preterm infants to inotropic therapy using adrenergic agonists. Dobutamine alone does not affect the cardiac adrenoceptors in the sham animals.
Bidirectional Tracking Robust Controls for a DC/DC Buck Converter‐DC Motor System
Authors: Hernández-Márquez Eduardo , García-Sánchez José Rafael , Silva-Ortigoza Ramón , Antonio-Cruz Mayra , Hernández-Guzmán Victor Manuel , Taud Hind , Marcelino-Aranda Mariana
Published: August 2018

Two differential flatness‐based bidirectional tracking robust controls for a DC/DC Buck converter‐DC motor system are designed. To achieve such a bidirectional tracking, an inverter is used in the system. First control considers the complete dynamics of the system, that is, it considers the DC/DC Buck converter‐inverter‐DC motor connection as a whole. Whereas the second separates the dynamics of the Buck converter from the one of the inverter‐DC motor, so that a hierarchical controller is generated. The experimental implementation of both controls is performed via MATLAB‐Simulink and a DS1104 board in a built prototype of the DC/DC Buck converter‐inverter‐DC motor connection. Controls show a good performance even when system parameters are subjected to abrupt uncertainties. Thus, robustness of such controls is verified.
Erzhi Formula Extracts Reverse Renal Injury in Diabetic Nephropathy Rats by Protecting the Renal Podocytes
Authors: Jiang Jun , Yin Jiangning , Liu Xiang , Wang Huajun , Lu Guoyuan
Published: August 2018

Podocytes injury was a crucial factor resulting in diabetic nephropathy (DN). Erzhi formula extract (EZF) was a clinical effective Chinese medicine on DN, but its mechanism was unclear. In this study, the main compounds of EZF and their pharmacokinetics in rat were detected by HPLC‐MS/MS. And then, blood glucose, urine protein, renal index, renal microstructural (HE/PAS staining), inflammatory factors (IL‐β, TNF‐α, IL‐6), and protein/mRNA expression related to the function of podocyte (CD2AP and Podocin) in DN rats were investigated after the oral administration of EZF. The concentrations of specnuezhenide and wedelolactone in rat kidney were 7.19 and 0.057 mg/kg, respectively. The Tmax of specnuezhenide and wedelolactone were 2.0 and 1.50 h, respectively. Their Cmax were, respectively, 30.24 ± 2.68 and 6.39 ± 0.05 μg/L. Their AUC(0-∞) were 123.30 ± 2.68 and 16.56 ± 0.98 μg/L⁎h, respectively. Compared with the model group, the blood glucose and the 24‐hour urinary protein were significantly decreased (P < 0.05) after 16 weeks’ treatment of EZF. The expressions of Podocin and CD2AP protein/mRNA were increased (P < 0. 05). The deteriorate of glomerular morphology was alleviated under the treatment of EZF. EZF prominently decreased the levels of inflammatory factors (P < 0.05). MDA was significantly decreased (P < 0.05) with the significant increase of SOD activity (P < 0.05) in EZF groups. All the results proved that EZF repaired glomerular mesangial matrix, protected renal tubule, and improved renal function in DN rats by upregulating the expression of Podocin and CD2AP protein/mRNA in podocytes.
Oxidative‐Nitrative Stress and Poly (ADP‐Ribose) Polymerase Activation 3 Years after Pregnancy
Authors: Horváth Eszter M. , Magenheim Rita , Béres Nóra J. , Benkő Rita , Pék Tamás , Tabák Ádám G. , Szabo Csaba
Published: August 2018

Background. Oxidative‐nitrative stress and poly (ADP‐ribose) polymerase activation have been previously observed in healthy and gestational diabetic pregnancies, and they were also linked to the development of metabolic diseases. The aim of the present study was to examine these parameters and their correlation to known metabolic risk factors following healthy and gestational diabetic pregnancies. Methods. Fasting and 2 h postload plasma total peroxide level, protein tyrosine nitration, and poly (ADP‐ribose) polymerase activation were measured in circulating leukocytes three years after delivery in women following healthy, “mild” (diet‐treated) or “severe” (insulin‐treated) gestational diabetic pregnancy during a standard 75 g OGTT. Nulliparous women and men served as control groups. Results. Fasting plasma total peroxide level was significantly elevated in women with previous pregnancy (B = 0.52 ± 0.13; p < 0.001), with further increase in women with insulin‐treated gestational diabetes (B = 0.36 ± 0.17; p < 0.05) (R2 = 0.419). Its level was independently related to previous pregnancy (B = 0.47 ± 0.14; p < 0.01) and current CRP levels (B = 0.06 ± 0.02; p < 0.05) (R2 = 0.306). Conclusions. Elevated oxidative stress but not nitrative stress or poly (ADP‐ribose) polymerase activation can be measured three years after pregnancy. The increased oxidative stress may reflect the cost of reproduction and possibly play a role in the increased metabolic risk observed in women with a history of severe gestational diabetes mellitus.
Metagenomic Approaches for Understanding New Concepts in Microbial Science
Authors: Alves Luana de Fátima , Westmann Cauã Antunes , Lovate Gabriel Lencioni , de Siqueira Guilherme Marcelino Viana , Borelli Tiago Cabral , Guazzaroni María-Eugenia
Published: August 2018

Over the past thirty years, since the dawn of metagenomic studies, a completely new (micro) universe was revealed, with the potential to have profound impacts on many aspects of the society. Remarkably, the study of human microbiome provided a new perspective on a myriad of human traits previously regarded as solely (epi-) genetically encoded, such as disease susceptibility, immunological response, and social and nutritional behaviors. In this context, metagenomics has established a powerful framework for understanding the intricate connections between human societies and microbial communities, ultimately allowing for the optimization of both human health and productivity. Thus, we have shifted from the old concept of microbes as harmful organisms to a broader panorama, in which the signal of the relationship between humans and microbes is flexible and directly dependent on our own decisions and practices. In parallel, metagenomics has also been playing a major role in the prospection of “hidden” genetic features and the development of biotechnological applications, through the discovery of novel genes, enzymes, pathways, and bioactive molecules with completely new or improved biochemical functions. Therefore, this review highlights the major milestones over the last three decades of metagenomics, providing insights into both its potentialities and current challenges.
Curvilinear Coordinate System for Mathematical Analysis of Inclined Buoyant Jets Using the Integral Method
Authors: Bloutsos Aristeidis A. , Yannopoulos Panayotis C.
Published: August 2018

The development of a local system of orthogonal curvilinear coordinates, which is appropriate to monitor the flow of an inclined buoyant jet with reference to the basic Cartesian coordinate system is presented. Such a system is necessary for the correct application of the integral method, since the well-known Gaussian profiles should be integrated on the cross-sectional area of inclined buoyant jet, where they are valid. This is the major advantage of the present work compared to all other integral methods using Cartesian coordinate systems. Consequently, the flow and mixing governing partial differential equations (PDE), i.e., continuity, momentum, buoyancy, and/or tracer conservation, are written in the local orthogonal curvilinear coordinate system and, then, the Reynolds substitution regarding mean and fluctuating components of all dependent variables is applied. After averaging with respect to time, the mean flow PDEs are taken, omitting second-order terms, as the dynamic pressure and molecular viscosity, compared to the mean flow and mixing contributions of turbulent terms. The latter are introduced through empirical coefficients. The Boussinesq’s approximation regarding small density differences is taken into consideration. The system of PDEs is closed by assuming known spreading coefficients along with Gaussian similarity profiles. The methodology is applied in the inclined two-dimensional buoyant jet; thus, PDEs are integrated on the jet cross-sectional area resulting in ordinary differential equations (ODE), which are appropriate to be solved by applying the 4th order Runge-Kutta algorithm coded in either FORTRAN or EXCEL. The numerical solution of ODEs, concerning trajectory of the inclined two-dimensional buoyant jet, as well as longitudinal variations of the mean axial velocity, mean concentration, minimum dilution, and entrainment velocity or entrainment coefficient, occurs quickly, saving computer memory and effort. The satisfactory agreement of results with experimental data available in the literature empowers the usefulness of the proposed methodology in inclined buoyant jets.
Cytotoxicity of the Aqueous Extract and Organic Fractions from Origanum majorana on Human Breast Cell Line MDA-MB-231 and Human Colon Cell Line HT-29
Authors: Makrane Hanane , El Messaoudi Mouhcine , Melhaoui Ahmed , El Mzibri Mohammed , Benbacer Laila , Aziz Mohammed
Published: August 2018

The toxicity of the aqueous extract of Origanum majorana was tested (5 and 10 g/kg) in albino mice. No symptoms of toxicity or mortality were observed. The mice survived being active and healthy during all 14 days of observation. In addition, the weight measurement of the left and right kidneys, heart, and liver shows no significant difference between the control, 5 g/kg, and 10 g/kg. All extracts (aqueous, petroleum ether, dichloromethane, ethyl acetate, methanolic, and depleted aqueous extracts) of Origanum majorana tested against both types of cancer cells showed a more pronounced cytotoxic effect against breast cell line MDA-MB-231 than colon cells line HT-29 cells. The most marked effect is that of the ethyl acetate extract with IC50 30.90 ± 1.39 and 50.11 ± 1.44 (µg/ml), respectively. HPLC analysis of extracts from Origanum majorana showed that this plant contained polyphenols and flavonoids, which may be responsible for the biological activities found.
Simulation and Experimental Tests of Ballistic Impact on Composite Laminate Armor
Authors: Soydan Ali Murat , Tunaboylu Bahadır , Elsabagh Ahmed Galal , Sarı Abdul Kadir , Akdeniz Recep
Published: August 2018

This paper presents the experimental testing and simulation results of ballistic impact tests on laminated armor samples that consist of three layers of different materials: fiber‐cement, Kevlar fabric, and steel. In experimental tests, a 9 mm FMJ bullet was launched towards a 100 cm2 sample of the armor from the fiber‐cement side. Ansys Workbench Explicit Dynamics and Ansys AUTODYN 3D were used to model and simulate the ballistic impact. Experimental testing and simulation results were compared to analyze the behavior of composite armor designs, and a good agreement was observed.
Solving a Large-Scale Multi-Depot Vehicle Scheduling Problem in Urban Bus Systems
Authors: Xu Xiaomei , Ye Zhirui , Li Jin , Wang Chao
Published: August 2018

This study proposes an improved model and algorithm for the large-scale multi-depot vehicle scheduling problem (MDVSP) with departure-duration restrictions. In this study, the time-space network is applied to model the large-scale MDVSP. Considering that crews usually change shifts in the depot, departure-duration restrictions are added to the classic set-partitioning model to ensure that buses return to the depot when crews reach their working time limits. By embedding a preliminary exploring tactic to the shortest path faster algorithm (SPFA), researchers developed an improved large neighborhood search (LNS) algorithm to solve large-scale instances of MDVSP with departure-duration restrictions. The proposed methodology is applied to a real-life case in China and several test instances. The results show that the improved LNS algorithm can achieve very good performance in computational efficiency without deteriorating solution quality, which is important for large-scale systems. More specifically, the total cost of the improved LNS algorithm is approximately equal to branch-and-price, but the computational time is much shorter in the case study. For test instances with different number of timetabled trips (500, 1000, 1500, and 2000), the Quality Gap (QG) is very small, approximately 0.35%, 0.38%, 0.63%, and 0.93%, while the Efficiency Ratio (ER) reaches up to 2.89, 2.98, 3.65, and 3.79, respectively.
Pogonatherumol, a Novel Highly Oxygenated Norsesquiterpene with Flavone C-Glycosides from Pogonatherum crinitum
Authors: Ni Lin , Huang Wei , Wang He-shan , Xu Hui-you
Published: August 2018

A novel highly oxygenated norsesquiterpene, pogonatherumol (1), with two known flavone C-glycosides (2-3), was isolated from Pogonatherum crinitum. The structure of the new compound was illuminated based on its spectroscopic data and X-ray analysis. Compounds 1 and 3 inhibited NO production in the mouse peritoneal macrophage (64.5 ± 7.2% and 61.6 ± 5.8%, respectively, at a concentration of 50 μM). The three compounds were inactive when tested against two human cancer cell lines (IC50 values > 50 μM).
Emerging Role of mTOR Signaling‐Related miRNAs in Cardiovascular Diseases
Authors: Samidurai Arun , Kukreja Rakesh C. , Das Anindita
Published: August 2018

Mechanistic/mammalian target of rapamycin (mTOR), an atypical serine/threonine kinase of the phosphoinositide 3‐kinase‐ (PI3K‐) related kinase family, elicits a vital role in diverse cellular processes, including cellular growth, proliferation, survival, protein synthesis, autophagy, and metabolism. In the cardiovascular system, the mTOR signaling pathway integrates both intracellular and extracellular signals and serves as a central regulator of both physiological and pathological processes. MicroRNAs (miRs), a class of short noncoding RNA, are an emerging intricate posttranscriptional modulator of critical gene expression for the development and maintenance of homeostasis across a wide array of tissues, including the cardiovascular system. Over the last decade, numerous studies have revealed an interplay between miRNAs and the mTOR signaling circuit in the different cardiovascular pathophysiology, like myocardial infarction, hypertrophy, fibrosis, heart failure, arrhythmia, inflammation, and atherosclerosis. In this review, we provide a comprehensive state of the current knowledge regarding the mechanisms of interactions between the mTOR signaling pathway and miRs. We have also highlighted the latest advances on mTOR‐targeted therapy in clinical trials and the new perspective therapeutic strategies with mTOR‐targeting miRs in cardiovascular diseases.
Energy-Efficient Enhancement for Viscoelastic Injection Rheomolding Using Hierarchy Orthogonal Optimization
Authors: Xu Jinghua , Wang Tiantian , Zhang Shuyou , Tan Jianrong
Published: August 2018

The viscoelastic injection molding involves multidisciplinary thermoplastic rheomolding parameters which is a complex mathematical problem. Particularly for rheomolding of complex parts with thin-walled structure, boss, and grooves, the increasing higher requirements on energy efficiency and rheomolding quality are put forward. Therefore, an energy-efficient enhancement method for viscoelastic injection molding using hierarchy orthogonal optimization (HOO) is proposed. Based on the thermoplastic rheomolding theory and considering the viscoelastic effects in injection molding, a set of partial differential equations (PDE) describing the physical coupling behavior of the mold-melt-injection molding machine is established. The fuzzy sliding mode control (FSMC) is used to reduce the energy consumption in the control system of the injection molding machine’s clamping force. Then, the HOO model of viscoelastic injection rheomolding is built in terms of thermoplastic rheomolding parameters and injection machine parameters. In initial hierarchy, through Taguchi orthogonal experiment and Analysis of Variance (ANOVA), the amount of gate, melt temperature, mold temperature, and packing pressure are extracted as the significant influence parameters. In periodical hierarchy, the multiobjective optimization model takes the forming time, warping deformation, and energy consumption of injection molding as the multiple objectives. The NSGA-II (Nondominated Sorting Genetic Algorithm II) optimization is employed to obtain the optimal solution through the global Pareto front. In ultimate hierarchy, three candidate schemes are compared on multiple objectives to determine the final energy-efficient enhancement scheme. A typical temperature controller part is analyzed and the energy consumption of injection molding is reduced by 41.85%. Through the physical experiment of injection process, the proposed method is further verified.
Modeling of Chloride Distribution in Cement‐Based Materials with Neumann Boundary Condition
Authors: Meng Qi , Zhang Yan , Lin Chun-jin , Jiang Lin-hua , Chen Da
Published: August 2018

The nonstable transport of chloride in cement‐based materials, including diffusion, convection, and chloride binding, is described as a general form of Fick’s law. Inspired by the heat transport of concrete, the second boundary condition called the Neumann boundary condition is considered in the chloride transport of concrete. The theoretical deduction of one‐dimensional chloride distribution with the Neumann boundary condition is performed, while a virtual boundary is introduced to carry out the approximate treatment. Finally, the comparison between the general Dirichlet boundary condition and the present Neumann boundary condition and the influence of the thickness of the virtual boundary as well as the influence of the water‐cement ratio (w/c) are discussed.
Synthesis of NiO/Y2O3/ZrO2 Catalysts Prepared by One-Step Polymerization Method and Their Use in the Syngas Production from Methane
Authors: Asencios Yvan J. O. , Assaf Elisabete M.
Published: August 2018

In this work, the production of Syngas (H2/CO) from oxidative reforming of methane (ORM) and partial oxidation of methane (POM) over NiO/Y2O3/ZrO2 catalysts was studied. The nickel concentration was varied (ranging from 0 to 40 wt.%) aiming to optimize the performance in ORM and POM reactions; these reactions were carried out at 750°C and 1 atm for 6 hours. The catalysts were prepared by the one-step polymerization method (OSP) and characterized by different techniques. This method led to production of materials of smaller crystallite size than others of similar composition prepared under other methods; the catalysts presented good nickel dispersion, well-defined crystalline structure, and well-defined geometrical morphology. Additionally, the OSP method was advantageous because it was carried out in a single calcination step. The catalyst containing 20% wt. of nickel (20Ni20YZ sample) showed the highest methane conversion, high selectivity to H2 and CO, low carbon deposition rates, and, curiously, the best geometric morphology. The results of this paper also demonstrated that the nickel concentration in the mixture strongly influenced the morphology of the catalysts; therefore, the morphology also influenced the catalytic performances during the Syngas production reactions.
Minimizing Cost Travel in Multimodal Transport Using Advanced Relation Transitive Closure
Authors: Oucheikh Rachid , Berrada Ismail , Omari Lahcen
Published: August 2018

The optimization computation is an essential transversal branch of operations research which is primordial in many technical fields: transport, finance, networks, energy, learning, etc. In fact, it aims to minimize the resource consumption and maximize the generated profits. This work provides a new method for cost optimization which can be applied either on path optimization for graphs or on binary constraint reduction for Constraint Satisfaction Problem (CSP). It is about the computing of the “transitive closure of a given binary relation with respect to a property.” Thus, this paper introduces the mathematical background for the transitive closure of binary relations. Then, it gives the algorithms for computing the closure of a binary relation according to another one. The elaborated algorithms are shown to be polynomial. Since this technique is of great interest, we show its applications in some important industrial fields.
Immunoglobulin G4 Sclerosing Cholangitis: An Unusual Cause of Obstructive Jaundice—Case Report and Literature Review
Authors: Shrestha Pragya , Le Brian , Wagner Brent , Pompella William , Karmacharya Paras
Published: August 2018

IgG4-related sclerosing cholangitis (IgG4-SC) is one of the most common extra-pancreatic manifestation of IgG4-related disease (IgG4-RD) and is clinically distinct from primary sclerosing cholangitis (PSC). IgG4-RD is an increasingly recognized immune-mediated fibroinflammatory systemic disease, mostly affecting middle-aged and older male populations that can affect multiple organs. The presence of extra-biliary clinical manifestations of IgG4-RD, such as parotid and lacrimal swelling, lymphadenopathy, autoimmune pancreatitis, and retroperitoneal fibrosis, if present could provide important clues to diagnosis. High serum IgG4 levels, characteristic radiological (e.g., sausage-shaped pancreas or periaortitis) or biopsy findings (high percentage of IgG4+ plasma cells, lymphoplasmacytic infiltrate, storiform fibrosis, or obliterative phlebitis) in the setting of these features is diagnostic of this disease process. However, isolated IgG4-SC might be a diagnostic challenge, and the distinction is important as management of this disorder is vastly different from other causes of cholangitis such as PSC. Systemic corticosteroid therapy is the mainstay of therapy.
The Brain Shadowing Sign: A Clue Finding for Early Suspicion of Craniosynostosis?
Authors: Dall’Asta Andrea , Paramasivam Gowrishankar , Lees Christoph , Ghi Tullio , Frusca Tiziana
Published: August 2018

Antenatal imaging of craniosynostosis mainly relies on the demonstration with 2D ultrasound of the abnormal contour of the calvarium and of the loss of hypoechogenicity of the synostotic sutures and on indirect signs of premature closure of the skull sutures; however, isolated craniosynostosis is detected only sporadically at prenatal ultrasound. In this article, we present the first case to our knowledge in which the “brain shadowing sign,” a recently described indirect sign of craniosynostosis, noted at 24 weeks in a structurally normal fetus, was the first clue for the diagnosis of isolated bilateral coronal craniosynostosis, which became evident at late gestation.
Cognitive Impairment, Sexual Activity and Physical Tenderness in Community-Dwelling Older Adults: A Cross-Sectional Exploration
Authors: Freak-Poli Rosanne , Licher Silvan , Ryan Joanne , Ikram M. Arfan , Tiemeier Henning
Published: August 2018

Background: The ability to engage in sexual activity and better cognitive functioning are both associated with better health. However, the association between cognitive functioning and sexual activity is understudied. Objective: To examine the association between cognitive functioning with sexual activity and physical tenderness among community-dwelling older adults. Methods: From the Rotterdam Study, cognitive impairment and sexual activity were assessed in 4,201 community-dwelling, 60+ year olds between 2008 and 2014 in the Netherlands. Mild cognitive impairment (MCI) was based upon subjective complaints related to age and education-adjusted test scores. Mini-Mental State Examination (MMSE) impairment was defined by a score of < 26. Sexual activity and physical tenderness (e.g., fondling or kissing) in the last 6 months were assessed at an interview. Analyses were stratified by gender and partner status, with prevalence rates for the “no impairment” categories weighted based on age from the cognitive impairment categories. Inter-rater reliability was examined utilising 74 cohabiting couples of opposite gender. Results: It was found that 14% were categorised as having cognitive impairment, and < 1% as dementia (excluded from subsequent analyses). There was strong evidence that the odds of engaging in physical tenderness (observed through MMSE < 26, OR 2.14, 95% CI 1.32–3.48, p = 0.002) and sexual activity (MCI, OR 2.36, 95% CI 1.35–4.12, p = 0.003) among partnered females with no impairment was twice that observed among cognitively impaired partnered females. There was weak evidence that the odds of engaging in physical tenderness (MMSE < 26, OR 1.59, 95% CI 1.04–2.42, p = 0.03) and sexual activity (MMSE < 26, OR 1.51, 95% CI 1.02–2.24, p = 0.04) among partnered males with no impairment was 50% greater than observed among cognitively impaired partnered males. The associations between cognitive functioning and physical tenderness continued to remain after adjustment for physical function, diabetes, cardiovascular disease and cancer. There was no clear evidence of a difference between amnestic and non-amnestic MCI for sexual behaviour. There was moderate to substantial agreement among the coupled adults who had 1 partner categorised with MCI. Conclusion: Having no cognitive impairment was associated with more engagement in sexual activity and physical tenderness among community-dwelling older adults. Sexuality is an important aspect of active aging and our findings illustrate a potential barrier to maintaining or instigating intimate relationships as we age. Longitudinal analyses are required to explore the direction of effect.
Survival after Aortic Valve Replacement for Aortic Regurgitation: Prediction from Preoperative Contractility Measurement
Authors: Borer Jeffrey S. , Supino Phyllis G. , Herrold Edmund McM. , Innasimuthu Antony , Hochreiter Clare , Krieger Karl , Girardi Leonard N. , Isom O. Wayne
Published: August 2018

Background: Noninvasive measurement of myocardial contractility (end-systolic wall stress-adjusted change in left ventricular ejection fraction from rest to exercise [ΔLVEF – ΔESS]) predicts heart failure, subnormal LVEFrest, and sudden death in asymptomatic patients with chronic severe aortic regurgitation (AR). Here we assess the relation of preoperative ΔLVEF – ΔESS to survival after aortic valve replacement (AVR). Methods: Patients who underwent AVR for chronic, isolated, pure severe AR (n = 66) were followed for 13.0 ± 6.4 event-free years. Preoperative ΔLVEF – ΔESS (from combined echocardiographic and radionuclide cineangiographic data) enabled cohort stratification into 3 terciles (–1 to –11% [normal or mild] contractility deficit, –12 to –16% [moderate], and ≤–17% [severe], identical with segregation in our earlier study) to relate preoperative contractility to postoperative survival and to age- and gender-matched US census data. Results: Since AVR, 22 patients died (average annual risk [AAR] for all-cause mortality for the entire co hort = 3.15%). Preoperative ΔLVEF – ΔESS predicted postoperative survival (p = 0.009, log rank test). By contractility terciles, all-cause AARs were 1.44, 2.58, and 6.40%. Survival was lower than among US census comparators (p < 0.02), but the “mild” tercile was indistinguishable from census data (p = ns). By multivariable Cox regression, survival prediction by pre-AVR ΔLVEF – ΔESS was independent of, and superior to, prediction by age at surgery, gender, preoperative functional class, LVEFrest, LVEFexercise, change in LVEFrest to exercise, and LV diastolic or systolic dimensions (p ≤ 0.01, pre-AVR ΔLVEF – ΔESS vs. other covariates). Conclusion: In severe AR, preoperative contractility predicts post-AVR survival and may be prognostically superior to clinical, geometric and performance descriptors, potentially impacting on patient selection for surgery.
Antithrombotic Therapy after Bioprosthetic Aortic Valve Replacement: A Therapeutic Morass
Authors: Gryaznov Anton A. , Saeyeldin Ayman , Abdelbaky Mohamed , Zafar Mohammad A. , Tanweer Maryam , Imran  Mahnoor , Papanikolaou Dimitra , Erben Young , Zefirova Julia , Ziganshin Bulat A. , Elefteriades John A.
Published: August 2018

Valvular heart disease is a common pathologic condition that affects 6 million people in the United States and more than 100 million worldwide. The most common valvular disorder is aortic stenosis. Current American and European guidelines recommend surgical management for symptomatic aortic stenosis with low risk of perioperative complications and endovascular intervention for high-risk patients with multiple comorbidities. Considering the increasing volume of aortic valve replacement (AVR) with biological valves, it is very important to select the appropriate anticoagulant after surgical AVR. In this article, we review the impact of anticoagulation on immediate and remote complications after AVR.
Is Axillary Sentinel Lymph Node Biopsy Required in Patients Who Undergo Primary Breast Surgery
Authors: Reimer Toralf , Engel Jutta , Schmidt Marcus , Offersen Birgitte Vrou , Smidt Marjolein L. , Gentilini Oreste David
Published: August 2018

Local treatment of the axilla in clinically node-negative (cN0) early breast cancer patients with routine sentinel lymph node biopsy (SLNB) is debated for various reasons: i) pN staging information may not be necessary for the postoperative treatment decision regarding adjuvant systemic therapy in the great majority of patients; ii) the SLNB-positive rate is declining below 20% in specialized breast centers; iii) albeit being a minimally invasive procedure, SLNB causes a significant reduction in quality of life in 23% of patients; and iv) previous randomized trials from the pre-SLNB era did not show a disadvantage for patients without axillary surgery with regard to overall survival. These data support the hypothesis that avoiding axillary treatment in patients with clinically and sonographically unsuspicious lymph nodes seems to be a safe option, although omitting axillary surgery may increase the risk of locoregional recurrence. Currently, the information regarding node-positive status is essential to guide postoperative treatment such as systemic or radiation therapies in a non-negligible minority of patients. Three ongoing prospective European trials (SOUND, INSEMA, BOOG 2013-08) with axillary observation alone versus SLNB in cN0 patients and primary breast-conserving surgery have the objective to evaluate oncologic safety when omitting SLNB.
Peak Troponin I Levels Are Associated with Functional Outcome in Intracerebral Hemorrhage
Authors: Gerner Stefan T. , Auerbeck Katrin , Sprügel Maximilian I. , Sembill Jochen A. , Madžar Dominik  , Gölitz Philipp , Hoelter Philip , Kuramatsu Joji B. , Schwab Stefan , Huttner Hagen B.
Published: August 2018

Background: Troponin I is a widely used and reliable marker of myocardial damage and its levels are routinely measured in acute stroke care. So far, the influence of troponin I elevations during hospital stay on functional outcome in patients with atraumatic intracerebral hemorrhage (ICH) is unknown. Methods: Observational single-center study including conservatively treated ICH patients over a 9-year period. Patients were categorized according to peak troponin I level during hospital stay (≤0.040, 0.041–0.500, > 0.500 ng/mL) and compared regarding baseline and hematoma characteristics. Multivariable analyses were performed to investigate independent associations of troponin levels during hospital stay with functional outcome – assessed using the modified Rankin Scale (mRS; favorable 0–3/unfavorable 4–6) – and mortality after 3 and 12 months. To account for possible confounding propensity score (PS)-matching (1: 1; caliper 0.1) was performed accounting for imbalances in baseline characteristics to investigate the impact of troponin I values on outcome. Results: Troponin elevations (> 0.040 ng/mL) during hospital stay were observed in 308 out of 745 (41.3%) patients and associated with poorer status on admission (Glasgow Coma Scale/National Institute of Health Stroke Scale). Multivariable analysis revealed troponin I levels during hospital stay to be independently associated with unfavorable outcome after 12 months (risk ratio [95% CI]: 1.030 [1.009–1.051] per increment of 1.0 ng/mL; p = 0.005), but not with mortality. After PS-matching, patients with troponin I elevation (≥0.040 ng/mL) versus those without had a significant higher rate of ­unfavorable outcome after 3 and 12 months (mRS 4–6 at 3 months: < 0.04 ng/mL: 159/265 [60.0%] versus ≥0.04 ng/mL: 199/266 [74.8%]; p < 0.001; at 12 months: < 0.04 ng/mL: 141/248 [56.9%] versus ≥0.04 ng/mL: 179/251 [71.3%]; p = 0.001). Conclusions: Troponin I elevations during hospital stay occur frequently in ICH patients and are independently associated with functional outcome after 3 and 12 months but not with mortality.
RUNX2 Plays An Oncogenic Role in Esophageal Carcinoma by Activating the PI3K/AKT and ERK Signaling Pathways
Authors: Lu Huibin , Jiang Tian , Ren Kewei , Li Zongming Li , Ren Jianzhuang , Wu Gang , Han Xinwei
Published: August 2018

Background/Aims: Esophageal carcinoma is a frequently occurring cancer at upper gastrointestinal tract. We aimed to evaluate the roles and possible mechanism of Runt Related Transcription Factor 2 (RUNX2) in the development of esophageal cancer. Methods: The expression of RUNX2 in esophageal carcinoma tissues and cells was investigated by qRT-PCR. Effects of RUNX2 on cell viability, apoptosis, migration and invasion were assessed using MTT assay, flow cytometry assay/western blot analysis, and Transwell assays, respectively. Afterwards, effects of RUNX2 on of the activation of the PI3K/AKT and ERK pathways were explored by Western blot analysis. In addition, a PI3K/AKT pathway inhibitor LY294002 and an ERK inhibitor U0126 were applied to further verify the regulatory relationship between RUNX2 and the PI3K/AKT and ERK signaling pathways. Besides, the RUNX2 function on tumor formation in vivo was investigated by tumor xenograft experiment. Results: The result showed that RUNX2 was highly expressed in esophageal carcinoma tissues and cells. Knockdown of RUNX2 significantly inhibited TE-1 and EC-109 cell viability, repressed TE-1 cell migration and invasion, and increased TE-1 cell apoptosis. RUNX2 overexpression showed the opposite effects on HET-1A cells. Moreover, RUNX2-mediated TE-1 cell viability, migration and invasion were associated with the activation of the PI3K/AKT and ERK pathways. Besides, knockdown of RUNX2 markedly suppressed tumor formation in vivo. Conclusion: Our results indicate that RUNX2 may play an oncogenic role in esophageal carcinoma by activating the PI3K/ AKT and ERK pathways. RUNX2 may serve as a potent target for the treatment of esophageal carcinoma.