bluuebunny/crossref_metadata_2025 huggingface dataset:
Feeling valued at work: a qualitative exploration of allied health profession support workers
Authors: Hall Abigail J. , Goodwin Victoria A. , Allchurch Lorraine , Capon Luke , Farrell Vicky , Olufunmilayo Oludare , Griffin Richard
Published: November 2024

Objectives

The aim of this study was to explore Allied Health Professions (AHP) support worker perceptions of feeling valued and to understand what factors contribute to this feeling of “value”.

Design

This was a qualitative study with semi-structured interviews undertaken virtually. The data were analysed using a process of thematic analysis in order to gain an in depth understanding of the factors that affect support workers feeling “valued”.

Setting and participants

Twenty-nine AHP support workers were recruited. They had a wide range of characteristics and experience in a variety of different settings and working with different professions. Participants all had experience of working in England and data collection was undertaken during February and March 2024.

Results

A sense of belonging, recognition for their skills and abilities, empowerment within their role, as well as opportunities to develop, were seen as key factors contributing to their feeling of value. Where support workers did not feel valued, they often referred to themselves as “just a support worker” and their skills and abilities were not fully utilised. Where support workers did feel valued, they thrived in their roles and enjoyed the opportunities that the role afforded them. There was significant variation in how valued our support workers felt which had a clear impact on them as people, but also would influence the care that they delivered.

Conclusion

AHP support workers are an integral part of the workforce, occupy diverse roles in healthcare and work collaboratively with registered staff, often prioritising patient care over their own career development and ambition. Recognising, empowering, and including them in teams is crucial for a supportive environment. Acknowledging their skills, providing learning opportunities, and supporting their development is essential for their well-being and fostering inclusivity in healthcare. By valuing and nurturing AHP support workers, we improve patient care and build a stronger healthcare workforce.
The impact of insurance status on psoriasis patients’ healthcare-seeking behavior: a population-based study in the United States
Authors: Sadrolashrafi Kaviyon , Hao Audrey , Yamamoto Rebecca K. , Guo Lily , Kikuchi Robin , Tolson Hannah C. , Bilimoria Sara N. , Yee Danielle K. , Armstrong April W.
Published: November 2024

Background

Psoriasis is a chronic, inflammatory skin condition requiring long-term care. However, many psoriasis patients may not regularly receive care. Several factors affect access to care in the United States, including health insurance status. Additionally, it is unknown how health insurance status impacts the healthcare-seeking behavior of psoriasis patients. Healthcare-seeking behavior is broadly defined as an individual’s actions to prevent or treat a perceived health problem, such as visiting a physician’s office. Because early diagnosis and timely treatment improve patient outcomes, determining how insurance status impacts psoriasis patients’ healthcare-seeking behavior and their ability to get care is important. This allows us to identify patients at risk for being untreated or undertreated. In this study, we aimed to assess the relationship between insurance status and (1) the degree to which psoriasis patients delay seeking or receiving care and (2) the degree to which psoriasis patients are unable to obtain care.

Methods

This population-based study used 20 years of data from the Medical Expenditure Panel Survey from 2002 to 2021. We calculated descriptive statistics and performed adjusted multivariable logistic regression analyses.

Results

We identified a weighted total of 4,506,850 psoriasis patients. Compared to those with private insurance, psoriasis patients with public-only insurance were 2.7 times more likely to delay seeking or receiving care (95% CI, 1.26–5.87). Compared to private insurance patients, uninsured psoriasis patients were 3.4 times more likely to be unable to obtain care (95% CI, 1.31–8.92). Compared to those with public-only insurance, uninsured psoriasis patients were 3.7 times more likely to be unable to obtain care (95% CI, 1.32–10.38).

Conclusions

This study found that psoriasis patients with public-only insurance were significantly more likely to delay seeking or receiving care compared to those with private insurance. This study also found that uninsured psoriasis patients were significantly more likely to be unable to obtain care than psoriasis patients with private insurance and those with public-only insurance. Developing strategies to increase healthcare access is necessary to ensure equitable, timely, and appropriate care for all psoriasis patients, regardless of their insurance status.
Transforming nursing work environments: the impact of organizational culture on work-related stress among nurses: a systematic review
Authors: Kiptulon Evans Kasmai , Elmadani Mohammed , Limungi Godfrey Mbaabu , Simon Klara , Tóth Lívia , Horvath Eva , Szőllősi Anna , Galgalo Dahabo Adi , Maté Orsolya , Siket Adrienn Ujváriné
Published: December 2024

Background

Creating a healthy and conducive nursing work environment is a universal global nursing concern. Work-Related Stress, global nursing and a public health problem that has continued to bedevil the world healthcare systems is of a particular interest. It has not only compromised the quality of patient care but also negatively impacted nurses’ quality of work life and adversely affected global healthcare management. Organizational culture is an important determinant of nurses’ work-related stress, yet it remains systematically under-researched. Despite a plethora of research on work-related stress in nursing environments, there are few dedicated systematic literature reviews, and this study aimed to fill this gap.

Objective

To determine the scientific evidence in the literature, on the impact of organizational culture on work-related stress among nurses and provide valuable insights to mitigation of work-related stress among nurses.

Design

A Systematic literature review.

Methods

The review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. A comprehensive literature search was conducted in major electronic databases, including PubMed, Scopus, Web of Science, Ovid Medline, Embase and CINAHL in July 2023. Studies that met the inclusion criteria set were screened using Rayyan and Covidence. The Mixed Methods Appraisal Tool (MMAT) was used to assess the quality and risk of bias.

Results

The search generated a total of 2,113 records, and 13 were included. Thematic analysis generated three main themes: types of organizational culture, organizational climate, and organizational politics, each with distinct effects on nurses’ work-related stress. We found overall that, positive organizational culture, positive organizational climate and positive organizational politics were consistently associated with nurse’s happiness and joy at the workplace and lower levels of work-related stress while negative organizational culture, climate and politics were strongly associated with nurses’ work-related stress.

Conclusions

This review underscores the crucial role of organizational culture in nursing work environments and its impact on nurses’ stress levels, offering valuable insights for the mitigation of work-related stress and the transformation of the nursing profession.
Genetic engineering of Nannochloropsis oceanica to produce canthaxanthin and ketocarotenoids
Authors: Canini Davide , Martini Flavio , Cazzaniga Stefano , Miotti Tea , Pacenza Beatrice , D’Adamo Sarah , Ballottari Matteo
Published: November 2024

Background

Canthaxanthin is a ketocarotenoid with high antioxidant activity, and it is primarily produced by microalgae, among which Nannochloropsis oceanica, a marine alga widely used for aquaculture. In the last decade, N. oceanica has become a model organism for oleaginous microalgae to develop sustainable processes to produce biomolecules of interest by exploiting its photosynthetic activity and carbon assimilation properties. N. oceanica can accumulate lipids up to 70% of total dry weight and contains the omega-3 fatty acid eicosapentaenoic acid (EPA) required for both food and feed applications. The genome sequence, other omics data, and synthetic biology tools are available for this species, including an engineered strain called LP-tdTomato, which allows homologous recombination to insert the heterologous genes in a highly transcribed locus in the nucleolus region. Here, N. oceanica was engineered to induce high ketocarotenoid and canthaxanthin production.

Results

We used N. oceanica LP-tdTomato strain as a background to express the key enzyme for ketocarotenoid production, a β-carotene ketolase (CrBKT) from Chlamydomonas reinhardtii. Through the LP-tdTomato strain, the transgene insertion by homologous recombination in a highly transcribed genomic locus can be screened by negative fluorescence. The overexpression of CrBKT in bkt transformants increased the content of carotenoids and ketocarotenoids per cell, respectively, 1.5 and 10-fold, inducing an orange/red color in the bkt cell cultures. Background (LP) and bkt lines productivity were compared at different light intensities from 150 to 1200 µmol m-2 s-1: at lower irradiances, the growth kinetics of bkt lines were slower compared to LP, while higher productivity was measured for bkt lines at 1200 µmol m-2 s-1. Despite these results, the highest canthaxanthin and ketocarotenoids productivity were obtained upon cultivation at 150 µmol m-2 s-1.

Conclusions

Through targeted gene redesign and heterologous transformation, ketocarotenoids and canthaxanthin content were significantly increased, achieving 0.3% and 0.2% dry weight. Canthaxanthin could be produced using CO2 as the only carbon source at 1.5 mg/L titer. These bkt-engineered lines hold potential for industrial applications in fish or poultry feed sectors, where canthaxanthin and ketocarotenoids are required as pigmentation agents.
Use of phase angle as an indicator of overtraining in sport and physical training
Authors: Annunziata Giuseppe , Paoli Antonio , Frias-Toral Evelyn , Marra Stellario , Campa Francesco , Verde Ludovica , Colao Annamaria , Lukaski Henry , Simancas-Racines Daniel , Muscogiuri Giovanna , Barrea Luigi
Published: November 2024

The use of bioelectrical impedance analysis (BIA) is now well established in healthcare as an essential support tool for patient management in various clinical settings. Its use in sports is rapidly expanding due to the valuable insights it offers, helping to better structure athletes’ diets and training programs, thereby optimizing their performance. In the context of sport, however, there is a consensus regarding the importance of proper interpretation of BIA-derived data, which cannot be limited to mere estimation of body composition. In this sense, therefore, the evaluation and interpretation of raw bioelectrical parameters, including resistance, reactance, and phase angle (PhA) is of relevant importance. The assessment of PhA is particularly significant in the context of sports, as it is closely linked to key factors such as muscle mass, strength, and overall muscle quality. However, the existing relationship between PhA and systemic, and loco-regional inflammation, which, in a broader sense, is the rationale behind its use for assessing and monitoring localised muscle damage. Thus, the importance of PhA monitoring during training becomes evident, as it plays a crucial role in assessing and potentially identifying functional impairments, such as overtraining syndrome, as well as muscle injury and related changes in fluid distribution, at an early stage. The aim of this review is to provide the scientific basis necessary to consider the use of whole-body PhA as an indicator of overtraining.
Exploring potential associations between the human microbiota and reservoir of latent HIV
Authors: Marín-Sánchez Nel , Paredes Roger , Borgognone Alessandra
Published: November 2024

Background

The rapid establishment and persistence of latent HIV-1 reservoirs is one of the main obstacles towards an HIV cure. While antiretroviral therapy supresses viral replication, it does not eradicate the latent reservoir of HIV-1-infected cells. Recent evidence suggests that the human microbiome, particularly the gut microbiome, may have the potential to modulate the HIV-1 reservoir. However, literature is limited and the exact mechanisms underlying the role of the microbiome in HIV immunity and potential regulation of the viral reservoir remain poorly understood.

Results

Here, we review updated knowledge on the associations between the human microbiome and HIV reservoir across different anatomical sites, including the gut, the lungs and blood. We provide an overview of the predominant taxa associated with prominent microbiome changes in the context of HIV infection. Based on the current evidence, we summarize the main study findings, with specific focus on consistent bacterial and related byproduct associations. Specifically, we address the contribution of immune activation and inflammatory signatures on HIV-1 persistence. Furthermore, we discuss possible scenarios by which bacterial-associated inflammatory mediators, related metabolites and host immune signatures may modulate the HIV reservoir size. Finally, we speculate on potential implications of microbiome-based therapeutics for future HIV-1 cure strategies, highlighting challenges and limitations inherent in this research field.

Conclusions

Despite recent advances, this review underscores the need for further research to deepen the understanding of the complex interplay between the human microbiome and HIV reservoir. Further integrative multi-omics assessments and functional studies are crucial to test the outlined hypothesis and to identify potential therapeutic targets ultimately able to achieve an effective cure for HIV.
A one-year follow-up case series on gait analysis and patient-reported outcomes for persons with unilateral and bilateral transfemoral amputations undergoing direct skeletal fixation
Authors: Toderita Diana , McGuire Tiereny , Benton Alice M. , Handford Charles , Ramasamy Arul , Hindle Paul , Bull Anthony M. J. , McMenemy Louise
Published: November 2024

Background

Direct skeletal fixation, a surgical technique enabling the attachment of an external prosthesis directly to the bone through a percutaneous implant, offers an enticing solution for patients with lower limb amputations facing socket-related issues. However, understanding of its impact on musculoskeletal function remains limited.

Methods

This study compares pre- and 1-year post-osseointegration surgery outcomes, focusing on patient-reported measures and musculoskeletal system function during level-ground walking. Two participants with unilateral transfemoral amputations and two participants with bilateral transfemoral amputations completed the questionnaire for transfemoral amputations (Q-TFA) and underwent gait analysis. Musculoskeletal modelling simulations were conducted.

Results

Results showed improved Q-TFA scores for all participants. Participants showed reduced amputated limb peak hip extension angles, flexion torques and contact forces at the push-off phase of the gait cycle. Post-operatively, hip adduction angles and abduction moments increased, indicating more natural gait patterns. Whilst one participant demonstrated increased post-operative walking speed, others walked more slowly.

Conclusions

The study revealed diverse adaptation patterns after one year in individuals with transfemoral amputations transitioning to bone-anchored prostheses. Additional longer-term data is necessary to enable generalization and clinical implications of these results.
Analyzing dropout intentions in vocational education and training: exploring the nexus between different dimensions of dropout reasons and the different directions of dropout intention
Authors: Braunstein Anke , Krötz Maximilian , Deutscher Viola , Seifried Jürgen
Published: November 2024

Extensive research has focused on various dimensions of dropout reasons, yet it often overlooks the importance of considering different dropout directions in the analysis. Our cross-sectional study examines the association of factors of six dimensions of dropout reasons (learner, professional, company, school, activity, and context) with four directions of dropout intention (upwards, downwards, horizontal: occupational change, and horizontal: company change). Stepwise regression analyses using dropout intention as a prior inner condition (before actual dropout behavior) with data from 559 industrial and office management trainees in Germany are conducted. Results indicate that the largest association across different directions of dropout intentions is exerted by the trainees’ occupational identity (professional dimension) and the year in training (context dimension). School factors like the use of outdated teaching equipment and learner factors like trainees’ high professional commitment predict upward dropouts, while a low level of trainees’ workplace social involvement (activity dimension) predicts downward dropouts. Company factors like unfavourable working regulations predict occupational change, and a low level of trainees’ functional involvement (activity dimension) predicts company change. Additionally, we confirm the previously found significant associations of activity and professional factors, particularly the cooperation between learning venues (school and training company) and the alignment between training and the desired occupation. The desired occupation predicts dropout intentions in the upward and horizontal direction (occupational change), and a low level of learning venue cooperation predicts the upward, horizontal (company change), and downward directions. To mitigate dropout rates, we recommend that vocational education and training stakeholders adopt preventive strategies by targeting specific directions of dropout intentions and the factors associated with the six dimensions of dropout reasons.
Vertebral monstrosities: phenotypically shortened fish with deformed vertebrae in endemic fish genus Hypselobarbus (Bleeker, 1860), (Teleostei: Cyprinidae) from Western Ghats, India
Authors: Mallegowda Jeevan Thiruguna , Devadas Dayal , Ramteke Karankumar , Jaiswar Ashok Kumar
Published: November 2024

Background

Fish with vertebral monstrosities are very rare in the wild, as those individuals in the natural populations tend to perform poorly to survive in any ecosystem. Species of the fish genus Hypselobarbus as reported (Bleeker in De visschen van den Indischen Archipel, Lange, 1860) are freshwater endemic barbs of Western Ghats and peninsular India. Four species of the genus, namely Hypselobarbus dobsoni (Krishna carp), H. jerdoni (Jerdon’s Carp), H. lithopidos (Canara barb) and H. thomassi (Red Canarese barb), were collected from three different river systems of the Western Ghats biodiversity hotspot of India. Some individuals were found to be different from normal specimens, with extremely large body depth compared to normal specimens. The study was initiated with the aim of bringing an understanding on monstrosities of these four species along with identifying the normal and abnormal individuals in an integrated approach; employing traditional morphometry, X-ray imaging and barcoding mtDNA COI X-ray imaging could elucidate the vertebral monstrosities, which are discussed in detail. The mtDNA COI gene sequences generated were used to draw conclusions on identity of both normal and deformed individuals.

Results

The phenotypic deformities have led to deepening of the body with a more robust and reduced length which is evident from the morphometric comparison of normal specimens with deformed ones. The radiographic images revealed reduced intra-vertebral space in comparison with the normal vertebrae, deformed vertebrae were between 25 and 32, showing significantly altered intra-vertebral space. Slight genetic divergence of 1.1% between normal and deformed specimens in mitochondrial DNA COI gene of H. lithopidos and H. thomassi and no divergence in H. dobsoni and H. jerdoni were also observed.

Conclusion

The specimens were collected from areas with high anthropogenic stresses, abate water quality, and habitat, which could be possible reasons of appearance of individuals with deformed vertebrae. Several environmental and genetic factors might have influenced the development of these robust short-bodied phenotypes in these rivers and possess slight genetic divergence from normal specimens. However, these deformities may also be the result of the stress during embryonic and early life stages in the wild.
Variants of TSC1 are associated with developmental and epileptic encephalopathy and focal epilepsy without tuberous sclerosis
Authors: Shen Nanxiang , Zhuo Zhihong , Luo Xiangyun , Li Bingmei , Lin Xuqing , Luo Sheng , Ye Zilong , Wang Pengyu , He Na , Shi Yiwu , Liao Weiping
Published: November 2024

Background

The TSC1 gene encodes a growth inhibitory protein hamartin, which plays a crucial role in negative regulation of the activity of mTORC1 (mechanistic target of rapamycin complex 1). TSC1 has been associated with tuberous sclerosis complex (TSC). This study aims to investigate the association between TSC1 variants and common epilepsy.

Methods

Trio-based whole-exome sequencing was performed in epilepsy patients without acquired etiologies from the China Epilepsy Gene 1.0 Project platform. The pathogenicity of the variants was evaluated according to the American College of Medical Genetics and Genomic (ACMG) guidelines.

Results

Two TSC1 de novo variants, including c.1498 C > T/p.Arg500* and c.2356 C > T/p.Arg786*, were identified in two patients with developmental and epileptic encephalopathy (DEE). The patients exhibited frequent seizures and neurodevelopmental delay. Additionally, we identified two heterozygous TSC1 variants that affected four individuals with focal epilepsy from two unrelated families. The four probands did not present any typical symptom of TSC and had normal brain MRI findings. The four variants were absent in the Genome Aggregation Database (gnomAD) and were predicted to be damaging with a in silico prediction tool. Based on the ACMG guidelines, the four variants were evaluated to be “pathogenic” or “likely pathogenic”. Of the patients in the China Epilepsy Gene 1.0 Project, 22 patients carried TSC1 variants and were diagnosed with TSC. The ratio of patients carrying TSC1 variants with or without TSC is about 5:1.

Conclusions

TSC1 is potentially associated with common epilepsy without tuberous sclerosis.
Radiology–pathology correlation of hormonal subtypes of breast cancer based on mammography, ultrasound, and PET imaging
Authors: Dsilva Rithi Melissa , Shivalingappa Shivakumar Swamy , Sampangi Sudhakar
Published: November 2024

Background

Breast cancer is one of the most common cancers among the female population globally and a major cause of death due to cancers among women. It has been classified into histopathological, hormonal, and molecular subtypes based on hormone receptor status. Their management involves a multidisciplinary approach depending on these subtypes, TNM staging, tumour size, and site. The purpose of this study was to assess the correlation between ultrasound and mammography characteristics and the maximum standardized uptake value on PET with hormonal subtypes of breast cancer.

Methods

It was a retrospective study from a single-centre data available for 8 months. In this study, 5 hormonal subtypes were considered; Luminal A, Luminal B, Luminal HER2-positive subtype, HER2-enriched subtype, and triple-negative subtype. The morphology of the lesions analysed on mammography and sonography and the SUV max value on PET were considered for analyses. The prediction performance of these features for the hormonal subtypes of breast cancers was then analysed.

Results

Luminal A and B subtypes of breast cancer had indistinct margins with posterior acoustic shadowing on ultrasound. Triple-negative subtypes were well-circumscribed lesions with posterior acoustic enhancement on ultrasound. HER2-positive lesions characteristically had pleomorphic microcalcifications with mixed posterior acoustic features on mammography. On PET, HER2-enriched cases had the highest SUV, and the Luminal A subtype had the lowest SUV.

Conclusion

According to our observations, there are certain typical morphological imaging characteristics for each hormonal subtype of breast cancer. These imaging modalities may help radiologists and clinicians in stratifying their patients for prognostication and better management.
A middle aged male with a rare cause of ataxia—A case report
Authors: Khanna Swati , Prakash Adity , Mohanty Sudhansu Sekhar , Swain Basanta Manjari
Published: November 2024

Background

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a rare and newly recognized long-standing inflammatory central nervous system (CNS) condition which primarily affects the pons, with characteristic clinical as well as radiological features. The aim of this work was to familiarize the radiologists with this rare but important neuroinflammatory condition.

Case presentation

We presented a report on a 33-year aged male who presented with gait imbalance, right-sided weakness, facial numbness, and dysarthria. Magnetic resonance imaging (MRI) revealed ill-defined hyperintensities in the pons, extending to the midbrain and cerebellum, with characteristic punctuate gadolinium enhancement. The patient received intravenous steroids for treatment, after which he began oral corticosteroids, leading to substantial recovery.

Conclusion

This case highlights the significance of identifying the distinct radiological characteristics of CLIPPERS, given its challenging diagnosis and the critical role of corticosteroid therapy in managing this condition. Despite advances in diagnostic criteria, neuropathological confirmation remains essential due to the condition's polymorphic presentation.
Phytoremediation and ethnomedicinal potential of Buddleja, Eremophila, Scrophularia, and Verbascum genera belonging to the Scrophulariaceae family: a review
Authors: Vazquez-Marquez Alicia Monserrat , Correa-Basurto José , Varela-Guerrero Víctor , González-Pedroza María Guadalupe , Zepeda-Gómez Carmen , Burrola-Aguilar Cristina , Nieto-Trujillo Aurelio , Estrada-Zúñiga María Elena
Published: December 2024

A number of species have developed detoxification strategies that allow them to accumulate high amounts of heavy metals in their tissues and grow despite a high heavy metal (HM) concentration in soils. Thus, they are considered hyperaccumulator or accumulator species, attractive for phytoremediation purposes. Families reported to contain a high number of hyperaccumulator species are Asteraceae, Euphorbiaceae, Rubiaceae, Fabaceae, Scrophulariaceae, Myrtaceae, Proteaceae, Caryophylaceae, and Tiliaceae. Indeed, the family Scrophulariaceae has a large extension, with Buddleja, Eremophila, Scrophularia, and Verbascum being some of the best-known genera containing species used for medicinal purposes. This review focuses on identifying the species used in folk medicine that belong to these four genera and can accumulate high concentrations of heavy metals (HMs). Additionally, the human health risks related to the consumption of HM hyperaccumulator species are discussed, as well as the feasibility of plant tissue culture to provide safe vegetal material for medicinal uses or to estimate the intrinsic potential of species for phytoremediation purposes. The following species have demonstrated the ability to accumulate HMs and grow in mine or HM-polluted soils, as well as use in traditional medicine: Buddleja asiatica, B. cordata, B. davidii, B. lindleyana, B. macrostachya, B. paniculata, B. scordioides, Eremophila latrobei, Scrophularia canina subsp. bicolor, S. ningpoensis, S. striata, Verbascum bombyciferum, V. olympicum, V. phrygium, and V. thapsus. In some of these species, antioxidant machinery has been proven to participate as a defense strategy against exposure to high HM concentrations. Consuming plants that accumulate high amounts of HMs has been described as a potential risk to human health. Plant tissue culture has also been established in a few of these species, whether to propagate or use them as a bioactive phytochemical source. Promoting safety and quality control related to the HM concentrations in the tissues of these plants used by populations for curative purposes is necessary. Further research must be carried out on several species for phytoremediation purposes.

Graphical abstract
Recent advances and future directions in banana molecular biology and breeding
Authors: Cheng Chunzhen , Wu Shuofan , Deng Guiming , Sheng Ou , Yi Ganjun , Yang Qiaosong
Published: December 2024

Since publication of a draft genome of the doubled-haploid ‘Pahang’ banana (Musa acuminata, DH-Pahang), a new era for banana biology research has begun. With the release of genomic data from some important Musa species and subspecies and the continuous development of molecular biology techniques, significant progress has been made. Here, we summarize the achievements and advances in the banana molecular biology and breeding over the past decade covering origin and domestication, fruit biology, stress biology, and breeding aspects, and highlight their challenges and future perspectives. This review is intended to provide researchers with the latest information on the complex genetic background and evolutionary relationship of bananas, the biology of fruit ripening, and multi-omics-based stress biology research. We especially focus on recent advances in the molecular breeding of bananas, offering an informative research direction and providing valuable technical references for future research in the field.
Review of current status and ongoing reforms of the mental health system in Uzbekistan
Authors: Smekhov Evgeniy
Published: December 2024

Uzbekistan's mental health system is undergoing significant reform aimed at improving care and service delivery. This article provides a comprehensive evaluation of the current state of Uzbekistan's mental health system using the WHO 2010 monitoring and evaluation framework. It also details ongoing reforms designed to address systemic issues, enhance mental healthcare and ensure better health outcomes for the population.
The m5C reader protein Ybx1 promotes axon growth by regulating local translation in axons
Authors: Yu Jun , Zhang Yanbo , Zhang Jian , Che Pengfei , Long Gaoxin , Yang Zhuoxuan , Ji Sheng-Jian
Published: November 2024

It has been shown that 5-methylcytosine (m5C), one of the most abundant modifications on RNA, regulates various biological processes. However, the function of m5C modification in the nervous system is still largely unknown. Here, we show that the m5C reader Ybx1 is highly expressed in the developing mouse hippocampus in the central nervous system (CNS). Conditional knockout of Ybx1 in the dentate gyrus (DG) decreases mossy fiber growth and affects short-term memory. In the peripheral nervous system (PNS), the mRNA of Ybx1 is enriched in the axons of dorsal root ganglion (DRG) neurons and can be locally translated. Inhibition of local translation of Ybx1 results in a decrease in axon growth. We further identify 28 target mRNAs of Ybx1 in DRG neurons, including Ttl and Mmp24. Axon-specific knockdown of Ttl and Mmp24 decreases axon growth rate both in DRG and DG. It could be a general mechanism that locally translated Ybx1 regulates axon growth by controlling local translation in both CNS and PNS.
flt1 inactivation promotes zebrafish cardiac regeneration by enhancing endothelial activity and limiting the fibrotic response
Authors: Wang Zhen-Yu , Mehra Armaan , Wang Qian-Chen , Gupta Savita , Ribeiro da Silva Agatha , Juan Thomas , Günther Stefan , Looso Mario , Detleffsen Jan , Stainier Didier Y. R. , Marín-Juez Rubén
Published: November 2024

VEGFA administration has been explored as a pro-angiogenic therapy for cardiovascular diseases including heart failure for several years, but with little success. Here, we investigate a different approach to augment VEGFA bioavailability: by deleting the VEGFA decoy receptor VEGFR1 (also known as FLT1), one can achieve more physiological VEGFA concentrations. We find that after cryoinjury, zebrafish flt1 mutant hearts display enhanced coronary revascularization and endocardial expansion, increased cardiomyocyte dedifferentiation and proliferation, and decreased scarring. Suppressing Vegfa signaling in flt1 mutants abrogates these beneficial effects of flt1 deletion. Transcriptomic analyses of cryoinjured flt1 mutant hearts reveal enhanced endothelial MAPK/ERK signaling and downregulation of the transcription factor gene egr3. Using newly generated genetic tools, we observe egr3 upregulation in the regenerating endocardium, and find that Egr3 promotes myofibroblast differentiation. These data indicate that with enhanced Vegfa bioavailability, the endocardium limits myofibroblast differentiation via egr3 downregulation, thereby providing a more permissive microenvironment for cardiomyocyte replenishment after injury.
IMAGINATIVE COMPONENT OF THE LINGUO-CULTURAL CHARACTER TYPE «BUSINESS MAN» IN RUSSIAN AND ENGLISH
Authors: Ilyinova Elena V.
Published: November 2024

Background. Since the beginning of the 2000s the theory of linguo-cultural types has been developing in Russian linguistics. Still, the linguo-cultural type ‘business man’ has not yet received its comprehensive description.
Purpose. To identify common and specific features of the imaginative component of the linguo-cultural type ‘business man’ and its subtypes in the Russian and English languages.
Materials and methods. The research is based on the comparative-descriptive method and thematic analysis method. The research material is a sample of examples from the Russian National Corpus and the Corpus of Contemporary American English from 2000 to 2019, containing lexemes nominating the linguo-cultural types under study (several thousand examples for each language). Excluded from the analysis are examples in which these lexemes are used in other meanings, are part of names, or point to the realities of the past, other countries, or fantasy worlds.
Results. The common and specific features of the imaginative component of the linguo-cultural type ‘business man’ and its subtypes in the Russian and English languages are identified. The identified features relate both to the most important topics in the examples (‘age’, ‘mode of thought’, ‘career’, ‘criminality’, ‘wealth’, ‘success’), and to the characteristics attributed to these types. Differences in the use of different elements of lexical-semantic fields corresponding to these types are also revealed.
NON-USUAL WORD FORMATION IN MODERN GERMAN
Authors: Chukina Ekaterina S.
Published: November 2024

Non-usual word formation, being a moreunrestrictedwayofreplenishing the vocabularyof a language,canfill in the gaps of traditional word formation,producecreative,rebus,expressivenominations; it is characterized by increasingimportanceinmodernGerman,especiallyin the field of Internetcommunication.Dueattention is notpaid to the study of theseprocessesandnewGermanwordsformed in non-conventional ways.
The purpose of the study is to generalize and systematize the available theoretical research results in the domestic and foreign linguistics of non-usual word formation, to determine the types of non-casual word formation used in modern German and the trends of neologization.
Methodology. The research material is the actual nominations of objects of reality functioning in today's Internet communication, relating to different spheres of life of German society. Word-formation analysis, elements of semantic and morphological analysis are used.
Results. It is shown that all the distinguished types of non-formal word formation are used in modern German. The most frequent are lexicalization of abbreviations, elimination, contamination, substitution, and centaur words. Neologization through non-formal word formation is characterized by tendencies towards internationalization, intensification, integration and intellectualization.
Practical implications. The materials and research results can be used in the educational process in the training of specialists in the field of communication in German, in lexicographic practice, in the development of research methodology on related topics.
THE ACTIVITIES OF THE VLADIMIR PROVINCIAL ADMINISTRATION IN THE EDUCATIONAL SPHERE IN THE SECOND HALF OF THE 19th – BEGINNING OF THE 20th CENTURY
Authors: Kudryashov Kirill O.
Published: November 2024

Background. The functions of the provincial administration in the socio-cultural sphere underwent changes because of the significant disturbances in the powers of the governor's corps at the regional level in the second half of the 19th – early 20th centuries. This trend was facilitated not only by new local government bodies and committees created because of liberal reforms, but also by the subsequent sharp change in government policy, which in the 1980s acquired a conservative direction. The assessment of the provincial administration in interaction with educational institutions and charities remains ambiguous. The work analyzes clerical documentation and periodicals, which reveals the functions of the provincial administration in the field of education and charity in a new way.
Purpose – This study investigates the activities of the Vladimir provincial administration in the field of education and charity in the second half of the 19th – early 20th centuries.
Materials and methods. The basis for the study was the periodicals, such as the Vladimir Provincial Gazette, the Vladimir Diocesan Gazette, the Vladimirets Gazette, and the office documents of the State Archive of the Vladimir Region: correspondence of institutions, reports, and accounts. This work uses problem-chronological, genetic, and analytical methods to preserve the principles of historicity and consistency.
Results. The transitioning from a liberal model to a conservative one affected the principles of interaction between the governor's corps and provincial institutions on issues of education. In these areas, the administration of the Vladimir province adheres to the principles of supervision, control and clarification. The authorities are especially wary of educational institutions, due to the growth of opposition sentiments. Nevertheless, a characteristic feature inherent in the Vladimir province at the beginning of the 20th century was the rapprochement of governors and zemstvo institutions on issues of education, where the former tried to petition the highest government bodies for zemstvo initiatives on opening new educational institutions.
Application of research findings in practice. The results of this study can be used in the field of research of political and regional history of both Vladimir province and provinces with similar structure of governance. Also, the obtained results can be applied to teaching regional history of Vladimir region.
Domestic tourism
Authors: Egorenkov Leonid
Published: November 2024

The textbook examines the tourist and recreational resources and the tourist and recreational potential of Russia, the geography of tourist demand, recreation and tourist infrastructure. The most popular tourist and recreational centers, facilities and routes are marked and characterized.
A brief description of promising tourist and recreational areas of Russia is given, and Russia's place in world ecological tourism is shown. Attention is paid to the adaptive potential of the traveler and tourist, as well as the safety of tourism.
It is intended for students studying in the recreational and tourism profiles of the training area "Service and Tourism". It can be useful for teachers, college students and a wide range of readers planning a vacation in Russia.
Fundamentals of information culture and information security
Authors: Red'kina Natal'ya
Published: November 2024

The textbook is devoted to the most important pedagogical problem related to the development of personal information culture in the process of transformation of the information society and the socio-cultural environment, the emergence of information threats and the impact of information and communication technologies on all spheres of human activity and information needs of users.
It covers a wide range of issues related to understanding the role of information in society and the phenomenon of information culture. Modern trends in the development of the information society, legal, technical and organizational aspects of information security, Internet threats and ways to protect against them, as well as technologies to combat fakes are considered. Special attention is paid to the main types of analytical and synthetic processing of information (annotation, abstracting, etc.), the culture of information retrieval and document processing.
Meets the requirements of the federal state educational standards of higher education of the latest generation.
For students in the direction 51.03.03 "Socio-cultural activities", as well as for a wide range of students of higher and secondary specialized educational institutions, students of advanced training courses, practitioners of the socio-cultural sphere.
Business development in the Asia-Pacific region
Authors: Podbiralina Galina , Romashkina Valeriya
Published: November 2024

The textbook systematizes the theoretical and practical material of business development in the rapidly developing Asia-Pacific region. The authors assess the current trends in business development, which vary in size and nature of economic activity. The main purpose of the textbook is to form students' holistic understanding of the activities of various categories of business in the countries of the Asia—Pacific region, as well as the ability to analyze the performance of the business sector and draw informed conclusions about its effectiveness. Special attention is paid to the possible prospects for the development of small and medium-sized businesses, including in the context of modern geopolitical risks and increased competition in international markets.
The practical tasks (cases) and questions presented in the textbook to consolidate the material will help students acquire practical skills and abilities that can be useful in further professional activities.
Meets the requirements of the federal state educational standards of higher education of the latest generation.
For students and teachers of universities of economic profile studying under bachelor's degree programs, as well as students of advanced training programs studying the peculiarities of entrepreneurship and business organization.
Household economics. Moral Economics
Authors: Privalov Nikolay
Published: November 2024

The textbook on economics of a new type systematically combines the best traditions of "Household", classical political economy, other economic (German historical school, institutionalism) and non-economic disciplines (history, political science, sociology, cybernetics, biology, psychology, mathematics, law, etc.). The main methodological principle of interdisciplinary connections is consistency and focus on achieving balance at the level of an individual household. The main well—known models of household economics, family economics and human economic models are analyzed in the light of their adaptation to the cultural traditions of Russia, which is ensured by taking into account institutional factors affecting the household economy and feedback from readers - situational tasks and control questions on topical issues of Russian reality. The chronological principle of the presentation of the material is provided by linking economic models with the historical situation and the personalities of the outstanding authors who created them — Xenophon, Plato, Aristotle, W. Petty, E. Engel, J. Keynes, F. Engels, L. Morgan, M. Kovalevsky, etc. The traditions of the university textbook are complemented by elements of monographic research, in particular on the creation of a new human model — the "traditional man", the substantiation of the relationship between a specific management model in Russia and the traditional family model. Economic and organizational issues of household development in modern Russia are presented within the framework of traditional topics, taking into account the geopolitical conditions of the first decades of the 21st century — information and sanctions wars, new types of economic crises (coronavirus), the development of contradictions in the digital economy and the aggravation of the global crisis.
Meets the requirements of the federal state educational standards of higher education of the latest generation.
The textbook is intended for students studying economics and anyone interested in the problems of the modern economy and Russia's place in global geopolitics.
The program of Applied Political Research
Authors: Brodovskaya Elena , Dombrovskaya Anna , Zaslavskiy Sergey , Lukushin Vladimir
Published: November 2024

The textbook contains materials for the preparation of a program of applied political research. The proposed materials include the structure of the research program, the general logic of construction, the basic elements and the basic rules of their formation. The most common mistakes in the preparation of a policy research program are considered using examples, as well as recommendations for the successful preparation of this document.
Meets the requirements of the federal state educational standards of higher education of the latest generation.
For students in the bachelor's degree 41.03.04 "Political Science" and master's degree 41.04.04 "Political Science", as well as in related areas of training graduate students-political scientists, teachers, researchers and practitioners of socio-political processes.
Pamięć afektywna. Dynamika polskiej pamięci po 1989 roku
Authors: Tabaszewska Justyna
Published: November 2024

Autorka stara się odpowiedzieć na pytanie, jak funkcjonuje polska pamięć po 1989 roku i na ile literatura oraz inne media pamięci mogą służyć jako przestrzeń wyrażania, negocjowania i wreszcie zmiany poszczególnych trybów pamiętania. Główny punkt zainteresowania monografii to dynamiczna, ciągle ewoluująca relacja czasowa między teraźniejszością, z perspektywy której pamiętamy, przeszłością, która jest w ten sposób odtwarzana i kształtowana, oraz przyszłością, której wizje niepostrzeżenie kolonizują zarówno pamięć zbiorową, jak i społeczny odbiór teraźniejszości.

Celem publikacji jest opisanie polskiej kultury widzianej z perspektywy badań nad pamięcią i afektami, w których akcentuje się jej wcześniej pomijane wymiary. Analiza zróżnicowanych tekstów (powieści Tulli, Twardocha, Stasiuka, Masłowskiej, Karpowicza, Łozińskiego, Rejmer, Szczerka, Dukaja i Orbitowskiego oraz filmów Miasto 44, Róża, Wołyń oraz Ida, a także serialu 1983) służy wypełnieniu badawczej luki, a więc zmapowaniu nierzadko splątanych relacji czasowych, które przez polską kulturę są odtwarzane i tworzone. Prześledzenie tych skomplikowanych zależności temporalnych oraz ich wpływu na procesy kształtowania pamięci zbiorowej odsłania, jak ważną – i jak do tej pory słabo zbadaną – rolę odgrywają wyobrażenia dotyczące przyszłości we współczesnej polityce afektywnej i pamięciowej.