bluuebunny/crossref_metadata_2025 huggingface dataset:
New Trends in Anti-Cancer Therapy: Combining Conventional Chemotherapeutics with Novel Immunomodulators
Authors: Wilson Amy L. , Plebanski Magdalena , Stephens Andrew N.
Published: November 2018

Cancer is one of the leading causes of death worldwide, and current research has
focused on the discovery of novel approaches to effectively treat this disease. Recently, a considerable
number of clinical trials have demonstrated the success of immunomodulatory
therapies for the treatment of cancer. Monoclonal antibodies can target components of the
immune system to either i) agonise co-stimulatory molecules, such as CD137, OX40 and
CD40; or ii) inhibit immune checkpoints, such as cytotoxic T-lymphocyte-associated antigen
4 (CTLA-4), programmed cell death-1 (PD-1) and its corresponding ligand PD-L1. Although
tumour regression is the outcome for some patients following immunotherapy, many patients
still do not respond. Furthermore, chemotherapy has been the standard of care for most cancers,
but the immunomodulatory capacity of these drugs has only recently been uncovered.
The ability of chemotherapy to modulate the immune system through a variety of mechanisms,
including immunogenic cell death (ICD), increased antigen presentation and depletion
of regulatory immune cells, highlights the potential for synergism between conventional chemotherapy
and novel immunotherapy. In addition, recent pre-clinical trials indicate dipeptidyl
peptidase (DPP) enzyme inhibition, an enzyme that can regulate immune cell trafficking to
the tumour microenvironment, as a novel cancer therapy. The present review focuses on the
current immunological approaches for the treatment of cancer, and summarizes clinical trials
in the field of immunotherapy as a single treatment and in combination with chemotherapy.
The Impact of Ultraviolet Radiation on Barrier Function in Human Skin: Molecular Mechanisms and Topical Therapeutics
Authors: Alhasaniah Abdulaziz , Sherratt Michael J. , O'Neill Catherine A.
Published: November 2018

A competent epidermal barrier is crucial for terrestrial mammals. This barrier must keep in water and prevent entry of noxious stimuli. Most importantly, the epidermis must also be a barrier to ultraviolet radiation (UVR) from the sunlight. Currently, the effects of ultraviolet radiation on epidermal barrier function are poorly understood. However, studies in mice and more limited work in humans suggest that the epidermal barrier becomes more permeable, as measured by increased transepidermal water loss, in response UVR, at doses sufficiently high to induce erythema. The mechanisms may include disturbance in the organisation of lipids in the stratum corneum (the outermost layer of the epidermis) and reduction in tight junction function in the granular layer (the first living layer of the skin). By contrast, suberythemal doses of UVR appear to have positive effects on epidermal barrier function.

Topical sunscreens have direct and indirect protective effects on the barrier through their ability to block UV and also due to their moisturising or occlusive effects, which trap water in the skin, respectively. Some topical agents such as specific botanical extracts have been shown to prevent the loss of water associated with high doses of UVR.

In this review, we discuss the current literature and suggest that the biology of UVR-induced barrier dysfunction, and the use of topical products to protect the barrier, are areas worthy of further investigation.
The Potential of Receptor for Advanced Glycation End Products (RAGE) as a Therapeutic Target for Lung Associated Diseases
Authors: Khaket Tejinder Pal , Kang Sun Chul , Mukherjee Tapan Kumar
Published: November 2018

The receptor for advanced glycation end products (RAGE) is a multi-ligand pattern recognition receptor that is highly expressed in lung epithelial cells. It helps alveolar epithelial cells to maintain their morphology and specific architecture. However, in various pathophysiological conditions, pulmonary tissues express a supraphysiological level of RAGE and its ligands including advanced glycation end products, high mobility group box 1 proteins, and S100 proteins. On interaction with RAGE, these ligands stimulate downstream signaling that generates inflammation and oxidative stress leading to asthma, chronic obstructive pulmonary disease, lung cancers, idiopathic pulmonary fibrosis, acute lung injury, pneumonia, bronchopulmonary dysplasia, cystic fibrosis, and sepsis. Thus, pharmacological agents that can either suppress the production of RAGE or block its biological activity would offer promising therapeutic value against pathogenesis of the aforementioned lungassociated diseases. This review presents a comprehensive overview of the recent progress made in defining the functions of RAGE in lung-associated diseases.
A New Schizophrenia Model: Immune Activation is Associated with the Induction of Different Neurotoxic Products which Together Determine Memory Impairments and Schizophrenia Symptom Dimensions
Authors: Sirivichayakul Sunee , Kanchanatawan Buranee , Thika Supaksorn , Carvalho André F. , Maes Michael
Published: November 2018

Objective: Recently, we reported that stable-phase schizophrenia is characterized by two interrelated symptom dimensions: PHEMN (psychotic, hostility, excitation, mannerism and negative symptoms); and DAPS (depressive, anxiety and physio-somatic symptoms) and that Major Neuro-Cognitive psychosis (MNP) is the full-blown phenotype of schizophrenia (largely overlapping with deficit schizophrenia). Herein we examined the effects of immune activation in association with tryptophan catabolite (TRYCAT) patterning and memory disorders on PHEMN/DAPS dimensions and MNP.

Methods:

Serum levels of macrophage inflammatory protein-1 (MIP-1), soluble interleukin (IL)-1 receptor antagonist (sIL-1RA), IL-10, eotaxin, IgA/IgM responses to TRYCATs, and Consortium to Establish a Registry for Alzheimer’s disease (CERAD) tests were assessed in 40 controls and 80 schizophrenia patients.

Results:

Schizophrenia and MNP were predicted by significantly increased levels of IL-10, eotaxin and TRYCATs. A large part of variance in both PHEMN/DAPS symptom dimensions (42.8%) was explained by cytokine levels and TRYCATs combined. The MIP+sIL-1RA+IL-10 composite score and eotaxin explained each around on the basis of 19% of the variance in symptom dimensions, and approximately 18% of memory deficits. Moreover, MIP+sIL-1RA+IL-10 was significantly associated with elevations in picolinic acid, xanthurenic acid and 3-OH-kynurenine. Partial Least Squares path modeling shows that highly significant effects of MIP+sIL-1RA+IL-10 on symptomatology are mediated by the effects of noxious TRYCATs on memory deficits.

Conclusion:

Current findings indicate that in schizophrenia, immune activation may underpin activation of indoleamine-2,3-dioxygenase and kynurenine monooxygenase, while impairments in episodic and semantic memory may be caused by the neurotoxic effects of TRYCATs and eotaxin. The combined effects of immune activation, eotaxin and memory defects determine to a large extent, PHEMN/DAPS symptoms and the MNP phenotype. These findings indicate that schizophrenia phenomenology is largely mediated by multiple neuro-immune pathways and that immune activation, increased production of eotaxin and neurotoxic TRYCATs (picolinic acid, xanthurenic acid and 3-HOkynurenine) are new drug targets in schizophrenia and MNP.
Patents for the Physiological Quality in Seeds of Peach Rootstock Classified by Weight and Stored for Different Periods
Authors: Souza Aline G. , Smiderle Oscar J. , Menegatti Renata D. , de Lima Marcos Aurélio C. , das Neves Tainá R. , Bianchi Valmor J.
Published: November 2018

Background:

Among stone fruit, the peach (Prunus persica (L) Batsch) is one of the
most widely grown species in Brazil, in both area cultivated and in production.

Objective:

The aim of this study was to evaluate the physiological quality of heavy and light seeds
of four cultivars of Prunus persica for two storage periods, from tests of electrical conductivity,
germination, and an analysis of initial plantlets growth.

Methods:

The Electrical Conductivity test (EC) was conducted in a Completely Randomised Design
(CRD), in a 4 x 2 x 5 factorial scheme with five replications. The germination test was carried
out in CRD, in a 4 x 2 factorial scheme with eight replications. The physiological quality of the
seeds was determined at zero and twelve month’s storage. For the growth analysis, the experimental
design was in CRD, in a 4 x 2 factorial scheme with four replications.

Results:

Under the conditions of the present study, it was found that the tests of germination and
electrical conductivity were complementary in evaluating physiological quality in seeds of Prunus
persica rootstock, suggesting that independent of the weight of the seeds, in ‘Capdeboscq’, ‘Aldrighi’,
‘Okinawa’ and ‘Okinawa Roxo’, there is a loss of quality and viability when the seeds are
stored for a period of 12 months.

Conclusion:

Under the experimental conditions of the present study, it was concluded that storage
for a period of 12 months in Recent patents is not rather recommendable for maintaining quality
and viability in seeds of Prunus persica of the Capdeboscq, Aldrighi, Okinawa and Okinawa Roxo
cultivars.
Russian Deep-Sea Operations and Canadian Cybersecurity Issues
Authors: Vancouver CASIS
Published: November 2018

Abstract
Lessons Learned from Chinese Intelligence Officer Arrest
Authors: Vancouver CASIS
Published: November 2018

Abstract
The Chemnitz Raid
Authors: Vancouver CASIS
Published: November 2018

Abstract
European Energy: The Mediterranean Sea, North America as New Suppliers
Authors: Vancouver CASIS
Published: November 2018

Abstract
Improving Nutrition and Activity Behaviors Using Digital Technology and Tailored Feedback: Protocol for the LiveLighter Tailored Diet and Activity (ToDAy) Randomized Controlled Trial (Preprint)
Authors: Halse Rhiannon E , Shoneye Charlene L , Pollard Christina M , Jancey Jonine , Scott Jane A , Pratt Iain S , Dhaliwal Satvinder S , Norman Richard , Straker Leon M , Boushey Carol J , Delp Edward J , Zhu Fengqing , Harray Amelia J , Szybiak Maria A , Finch Anne , McVeigh Joanne A , Mullan Barbara , Collins Clare E , Mukhtar Syed Aqif , Edwards Kieran N , Healy Janelle D , Kerr Deborah A
Published: November 2018

BACKGROUND

Excess weight is a major risk factor for chronic diseases. In Australia, over 60% of adults are overweight or obese. The overconsumption of energy-dense nutrient-poor (EDNP) foods and low physical activity (PA) levels are key factors contributing to population obesity. New cost-effective approaches to improve population diet and PA behaviors are needed.

OBJECTIVE

This 1-year randomized controlled trial (6-month intervention and 6-month follow-up) aims to investigate whether a tailored intervention using mobile technology can improve diet and PA behaviors leading to weight loss in adults (aged 18-65 years) who are overweight or obese and recruited through a social marketing campaign (LiveLighter).

METHODS

All eligible participants will provide data on demographics and lifestyle behaviors online at baseline, 6 months, and 12 months. Using two-stage randomization, participants will be allocated into one of three conditions (n=200 per group): tailored feedback delivered via email at seven time points, informed by objective dietary (mobile food record app) and activity (wearable activity monitor) assessment; active control receiving no tailored feedback, but undergoing the same objective assessments as tailored feedback; and online control receiving no tailored feedback or objective assessments. Primary outcome measures at 6 and 12 months are changes in body mass, EDNP food and beverage consumption, and daily moderate-to-vigorous PA (measured via accelerometry). Secondary outcomes include change in fruit and vegetable consumption, daily sedentary behaviors, and cost effectiveness.

RESULTS

Enrolment commenced in August 2017. Primary outcomes at 12 months will be available for analysis from September 2019.

CONCLUSIONS

Tailored email feedback provided to individuals may deliver a cost-effective strategy to overcome existing barriers to improving diet and PA. If found to be successful and cost effective, upscaling this intervention for inclusion in larger-scale interventions is highly feasible.

CLINICALTRIAL

Australian New Zealand Clinical Trials Registry ACTRN12617000554369; https://www.anzctr.org.au /Trial/Registration/TrialReview.aspx?id=371325&isReview=true

INTERNATIONAL REGISTERED REPOR

DERR1-10.2196/12782
Best Practices for Data Visualization: Creating and Evaluating a Report for an Evidence-Based Fall Prevention Program (Preprint)
Authors: Khasnabish Srijesa , Burns Zoe , Couch Madeline , Mullin Mary , Newmark Randall , Dykes Patricia C
Published: November 2018

BACKGROUND

Data visualization experts have identified core principles to follow when creating visual displays of data that facilitate comprehension. Such principles can be applied to creating effective reports for clinicians that display compliance with quality improvement protocols. A basic tenet of implementation science is continuous monitoring and feedback. Applying best practices for data visualization to reports for clinicians can catalyze implementation and sustainment of new protocols.

OBJECTIVE

To apply best practices for data visualization to create reports that clinicians find clear and useful.

METHODS

First, we conducted a systematic literature review to identify best practices for data visualization. We applied these findings and feedback collected via a questionnaire to improve the Fall TIPS Monthly Report (FTMR), which shows compliance with an evidence-based fall prevention program, Fall TIPS (Tailoring Interventions for Patient Safety). This questionnaire was based on the requirements for effective data display suggested by expert Stephen Few. We then evaluated usability of the FTMR using a 15-item Health Information Technology Usability Evaluation Scale (Health-ITUES). Items were rated on a 5-point Likert scale from strongly disagree (1) to strongly agree (5).

RESULTS

The results of the systematic literature review emphasized that the ideal data display maximizes the information communicated while minimizing the cognitive efforts involved with data interpretation. Factors to consider include selecting the correct type of display (e.g. line vs bar graph) and creating simplistic reports. The qualitative and quantitative evaluations of the original and final FTMR revealed improved perceptions of the visual display of the reports and their usability. Themes that emerged from the staff interviews emphasized the value of simplified reports, meaningful data, and usefulness to clinicians. The mean (SD) rating on the Health-ITUES scale when evaluating the original FTMR was 3.86 (0.19) and increased to 4.29 (0.11) when evaluating the revised FTMR (Mann Whitney U Test, z=-12.25, P<0.001).

CONCLUSIONS

Best practices identified through a systematic review can be applied to create effective reports for clinician use. The lessons learned from evaluating FTMR perceptions and measuring usability can be applied to creating effective reports for clinician use in the context of other implementation science projects.
Educación y reproducción de sociedades no capitalistas. El caso de alumnos de telebachillerato y la Empresa Forestal Comunitaria de San Pedro el Alto, México
Authors: Rosas-Baños Mara , Santiago Jiménez María Evelinda , Lara-Rodríguez Ruth
Published: November 2018

En este texto se analiza el caso de los jóvenes de telebachillerato de la agencia de San Pedro el Alto, Oaxaca, México, para explorar la perspectiva de los jóvenes sobre su futuro profesional; su permanencia en la comunidad; la gestión de la empresa a través de los usos y costumbres; y sus motivaciones para trabajar en la Empresa Forestal Comunitaria a la luz de la perspectiva de la sociología de la educación y la pedagogía crítica. El estudio es de tipo explicativo; la recopilación de datos se realizó mediante cuestionarios de preguntas semiabiertas que cubrieron 90 por ciento de la población de jóvenes. Se concluye que existen oportunidades para reenfocar la ideología transmitida a los jóvenes que estudian la educación media superior, a través de la construcción de espacios comunitarios de intercambio entre autoridades comunitarias y los jóvenes, como medio para mitigar las percepciones construidas en la escuela y ampliar las propias.
Nivel de desarrollo de las competencias y objetivos generales del Máster Formación del Profesorado de Enseñanza Secundaria
Authors: Serrano Rodríguez Rocío , Pontes Pedrajas Alfonso
Published: November 2018

En este trabajo se presentan los resultados obtenidos del análisis de las opiniones de 353 estudiantes sobre el Máster Formación del Profesorado de Enseñanza Secundaria de la Universidad de Córdoba (España) (Máster FPES), mediante un cuestionario escala Likert diseñado para valorar el nivel de desarrollo adquirido en las competencias generales de dicho máster. Los resultados muestran un nivel de satisfacción moderado en la valoración de la mayoría de los fines formativos y competencias, identificándose varios núcleos de opiniones que podrían considerarse como subdimensiones diferenciadas dentro del pensamiento inicial sobre las competencias docentes. También se ha observado la existencia de un factor principal, que agrupa a la mayoría de las variables (competencias básicas), y dos factores secundarios que incluyen al resto (competencias secundarias).
Articulaciones y disputas en la trama entre trabajo docente e igualdad educativa en Argentina
Authors: Vassiliades Alejandro
Published: November 2018

Este artículo analiza cómo la docencia en Argentina ha sido el lugar de llegada de una multiplicidad de significaciones que pugnaron por fijarla a diversos sentidos. Como significante abierto y no definido a priori, se constituyó en un campo de disputas y conflictos. Este trabajo presenta una discusión respecto del modo en que trabajo docente e igualdad educativa se articularon históricamente en dicho país y configuraron una trama compleja e inestable; se analizan sus inscripciones en cuatro momentos: el fundacional del magisterio, el de la última dictadura, el de las reformas de la década de 1990, y el de las políticas educativas desarrolladas en los últimos diez años. Estos periodos resultan momentos de fuerte condensación de debates en torno de esta articulación. El análisis se nutre de aportes metodológicos provistos por el análisis político del discurso y de investigaciones del campo del trabajo docente y la política e historia de la educación.
La creación de nuevas universidades nacionales en la década de los años setenta Continuidades y rupturas del plan Taquini en el marco de la coyuntura política nacional (1966-1973)
Authors: Mendonça Mariana
Published: November 2018

En este trabajo nos proponemos analizar las políticas universitarias implementadas tras la caída de Juan Carlos Onganía (presidente de Argentina 1966-1970), las cuales estuvieron orientadas a descentralizar las casas de altos estudios. Nos hemos propuesto dar cuenta del proceso que llevó a la implementación del denominado “Plan Taquini” y las transformaciones que el plan original sufrió desde su presentación hasta que finalmente se materializó como política de Estado, entre 1971 y 1973. Se analizan las medidas que se desarrollaron a lo largo de las tres presidencias de este periodo, así como el rol que jugaron las comunidades locales en las diferentes coyunturas políticas. Para ello, se abordan algunos de los casos particulares de creación de nuevas universidades, haciendo énfasis en la ciudad de Río Cuarto, lugar en que se construyó la primera de ellas.
Desigualdad educativa y desigualdad social en México. Nuevas evidencias desde las primarias generales en los estados
Authors: Tapia G. Luis Arturo , Valenti Giovanna
Published: November 2018

En la agenda de estudios sobre pobreza ha emergido una corriente que analiza la relación de ésta con la desigualdad educativa. Los datos disponibles en investigaciones, incluyendo los informes del INEE de 2014, sugieren que el sistema educativo mexicano está permeado por una dinámica que estratifica el acceso a los aprendizajes, lo que, se infiere, reproduce desigualdades. En esta perspectiva, el documento muestra nueva evidencia empírica de cómo la desigualdad social basada en el ingreso (medido por índice de Gini en los estados del país) se asocia a sistemas educativos estratificados socioeconómicamente incluso luego de descontar el efecto de las modalidades escolares con desventaja social (i.e. CONAFE y primarias indígenas). Los datos que se ofrecen indican que en México existen mecanismos de reproducción social que traducen de forma eficiente desigualdades contextuales en desigualdades entre centros escolares, lo que hace inequitativo el acceso a los aprendizajes de algunos segmentos de la población.
El camino hacia la profesionalización de la función directiva: el perfil competencial y la formación del director de centros educativos en España
Authors: Vázquez Toledo Sandra , Liesa Orús Marta , Bernal Agudo José Luis
Published: November 2018

Actualmente, ejercer la función directiva en los centros educativos de educación básica obligatoria de España es una tarea compleja y difícil, debido, entre otros factores, a la falta de profesionalización percibida. Este artículo pretende proporcionar un modelo de desarrollo profesional basado en el perfil directivo y la formación específica, por ser el camino hacia la profesionalización de dicha función. Para ello se analizan las competencias y necesidades formativas de los directores desde el marco normativo y la investigación. El perfil competencial obtenido se sustenta en una doble faceta: el director líder y el técnico-gestor, con un mayor peso del liderazgo. A partir de las competencias definidas se presentan diversas propuestas de mejora al modelo formativo actual, porque en la mayoría de las comunidades los contenidos de los cursos de formación para directores se ciñen a aspectos esencialmente formales o de gestión.
Indicadores de abandono escolar temprano: un marco para la reflexión sobre estrategias de mejora
Authors: García Fernández Beatriz
Published: November 2018

El objetivo de este trabajo es presentar un marco que facilite la comparación de indicadores de abandono escolar temprano entre los diferentes países europeos, Estados Unidos y México. Para ello se realizó un análisis comparativo considerando la definición y caracterización del fenómeno adoptadas en cada país y la contextualización en el correspondiente sistema educativo. Además se aporta una reflexión sobre el cumplimiento de distintos criterios de calidad de los indicadores referentes a este fenómeno. Se concluye que con el objetivo de mejorar la calidad de los indicadores en cuestiones como validez, confiabilidad, comparabilidad y actualidad, sería conveniente aumentar el tipo de dato, frecuencia de análisis y niveles de agregación, de modo que se posibilite una caracterización del problema más precisa. Se destaca el interés de contar con un indicador complementario que permita la comparabilidad a nivel internacional.
La enseñanza de la historia y la construcción de subjetividad política de niños y niñas de educación básica primaria
Authors: Peña Forero Nelsy Costanza , Cristancho Altuzarra José Gabriel
Published: November 2018

El artículo presenta los resultados de una investigación que se ocupó de comprender cómo la enseñanza de la historia influye en la construcción de subjetividad política en una institución educativa distrital de Bogotá en primero, segundo y tercero de básica primaria. Se presenta inicialmente el abordaje teórico que fundamentó la investigación y los rasgos metodológicos. Como resultados se identifican brechas entre las formas de entender y comprender la historia por parte de las docentes, y las prácticas que se desarrollan en el aula; se encuentra que la enseñanza de la historia sigue encaminada a la configuración de referentes tradicionales en relación a las identidades, lugares sociales, formas de participación y relaciones sociales tales que la construcción de la subjetividad política de niños y niñas se va gestando desde dimensiones moralizantes, donde lo que prevalece es la adaptación al entorno social y la construcción de identidad nacional.
Movilidad estudiantil universitaria: ¿qué factores inciden en la decisión de elegir Argentina como destino?
Authors: Corbella Virginia Inés , Elías Silvina
Published: November 2018

La internacionalización de la educación superior (IES) ha sido centro de atención desde hace tiempo en las universidades e institutos de educación superior. En los últimos años, la afluencia de jóvenes estudiantes universitarios internacionales a Argentina ha crecido considerablemente, es por ello que se plantea indagar cuáles son los factores que inciden en que los alumnos elijan la Universidad Nacional del Sur con el objetivo de cursar, complementar o concluir sus estudios de grado. Se realizaron 48 encuestas semi-estructuradas con estudiantes internacionales de grado (67 por ciento de la población total). Adicionalmente, ocho estudiantes fueron entrevistados para profundizar en la información expresada en la encuesta. Los resultados identificaron factores asociados a la recepción de estudiantes internacionales que fueron contemplados por los autores en la literatura y otros que no lo fueron. Se destacan los factores idioma, afinidad socio-cultural, educación pública y gratuita y facilidad de ingreso.
Conversación y mediación del aprendizaje en aulas de diversos contextos socioculturales
Authors: Villalta Paucar Marco Antonio , Assael Budnik Cecilia , Baeza Reyes Andrea
Published: November 2018

El objetivo del texto es analizar la estructura dialogal del salón de clase en diferentes contextos socioculturales. La metodología fue la observación de clases reales de 15 profesoras de primero básico en escuelas de contexto urbano y rural de Chile. Se realizó análisis de la conversación (AC), y de criterios de experiencia de aprendizaje mediado (EAM). Se empleó estadística no paramétrica. En los resultados se encontró: a) la gestión del tiempo depende del contexto directo de aula; b) hay asociación significativa entre conversación y criterios de EAM según contexto: las aulas urbanas se caracterizan por conversaciones expositivas, regulativas y cooperativas, relacionados con EAM de intencionalidad y reciprocidad, trascendencia, planificación, regulación y autocontrol, y desafío; en tanto las aulas rurales se caracterizan por: conversaciones co-formadas, explicativas y colaborativas asociadas con EAM, significado, trascendencia e individualización. Estos diferentes patrones dialogales permiten promover el aprendizaje autónomo desde la realidad de cada escuela.
Profesores principiantes de educación secundaria en Chile Pese a las dificultades, ¿qué los hace permanecer como docentes?
Authors: Zamora Poblete Guillermo Manuel , Meza Pardo Marisa , Cox Vial Pilar
Published: November 2018

El 42 por ciento de los profesores principiantes de educación secundaria de Chile abandona la docencia en los primeros cinco años de servicio. Esta situación se atribuye, entre otros factores, a las insatisfactorias condiciones laborales y al agotamiento emocional. Pese a las dificultades, hay un porcentaje significativo de profesores que permanecen. Los estudios acerca de ellos son escasos, pues la atención se ha concentrado en los que abandonan. El objetivo de esta investigación es justamente caracterizar la decisión para permanecer. Específicamente, interesa identificar la fuerza de la intención de permanecer y los factores escolares asociados. Se aplicó un cuestionario a 371 profesores principiantes, que incluye preguntas cerradas y la narración de un incidente escolar. El principal hallazgo es que la decisión de permanecer está asociada a la satisfacción que experimenta el profesor con la relación que mantiene con sus alumnos, particularmente respecto del reconocimiento y respeto que ellos le brindan.
Including household effects in Big Data research: the experience of building a longitudinal residence algorithm using linked administrative data in Wales
Authors: Tingay Karen Susan , Roberts Matthew , Musselwhite Charles B.A.
Published: November 2018

The effect of the wider social-environment on physical and emotional health has long been an area of study. Extrapolating the impact of the individual's immediate environment, such as living with a smoker or caring for a chronically-ill child, would potentially reduce confounding effects in health-related research. Surveys, including the UK Census, are beginning to collect data on household composition. However, these surveys are expensive, time consuming, and, as such, are only completed by a subsection of the population. Large-scale, linked databanks, such as the SAIL Databank at Swansea University, which hold routinely collected secondary use clinical and administrative datasets, are broader in scope, both in terms of the nature of the data held, and the population. The SAIL databank includes demographic data and a geographic indicator that makes it possible to identify groups of people that share accommodation, and in some cases the familial relationships among them. This paper describes a method for creating households, including considerations for how that information can be securely shared for research purposes. This approach has broad implications in Wales and beyond, opening up possibilities for more detailed population-level research that includes consideration of residential social interactions.
The application of structure equation modeling analysis for assessment and educational research
Authors: Costa Augusto Da
Published: November 2018

The purpose of this study is discovering and confirmingthe essentialfunction of Structure Equation Modeling (SEM) Analysis for assessment and educational research. The literatures in regards to SEM analysis as method of assessment and educational research will be descriptive analyzed and explored in the light of meta-analysis. The result of the study shown that by using SEM analysis ones get empirical data and clear picture of student’s need and do right assessment and research in education. The empirical data enable scholars and government to set new or revise current education program for the future. Therefore this result should be considered as important data for government, especially Education department to establish curriculum and planning strategy of teaching and learning which is conjunction with reality in the field. It means the education program that been established and will develop really match with real life and needs of student, society and the nation. So SEM analysis is important method for each researchers and scholars to run assessment and educational research now and beyond.
MAFIA AKAD DALAM PERBANKAN SYARIAH
Authors: Aziz Fathul Amin
Published: November 2018

The concept of Islamic banking is good enough, but the findings are substantial deviations in sharia banking practices in the field, among which are related to the contract which is the business core of the sharia bank itself. This condition should not be allowed to be dragged down, because the practice of deviation done by some sharia banks in this case is similar to the engineering of the sharia contract namely the conjunction of the product with the packaging of sharia services. Understanding the agreement will be important morning sharia banking practitioners as well as transparency on Sharia banks in order to prevent potential "mafia", which may exist in sharia banking in Indonesia. Keywords: Islamic Bank, Deviation, Mafia
Sumber Daya Alam Dalam Pembangunan Berkelanjutan Perspektif Islam
Authors: Qur'an Amanah Aida
Published: November 2018

Abstrak
Natural resources are a gift given by God almighty to mankind which is khalifa fil ard, but instead humanity is who makes the destruction of nature. Sustainable development is a pattern of development that takes into account the natural balance. Islam gives freedom to utilize the abundant natural resources, especially in Indonesia but there are limitations, also should pay attention to the balance of nature so that natural resources will still be maintained continuity. This study is used the library research. In this study will discuss the concept of natural resources in asustainable development perspective of Islam.
Keyword: Natural Resources, sustainable development, Islam.
SINERGITAS ISLAMIC MICROFINANCE INSTITUTION (IMFI): Pemberdayaan dan Peningkatan Kesejahteraan Usaha Mikro Kecil dan Menengah (UMKM)
Authors: Suharti Fisit
Published: November 2018

Dua dekade terakhir perkembangan ekonomi syariah ramai dengan munculnya berbagai lembaga keuangan syariah, termasuk di dalamnya adalah BMT dan lembaga zakat. Namun, lembaga zakat ini jauh lebih awal dibanding dengan BMT. Kedua lembaga ini memiliki kesamamaan dalam fungsi intermediary menghimpun dan menyalurkan dana ZIS dalam operasionalnya, tetapi di sisi lain keduanya juga memiliki sejumlah kendala, untuk itu dalam makalah ini penulis mencoba mensinergikan keduanya dalam rangka pemberdayaan masyarakat miskin dan peningkatan kesejahteraan Usaha Mikro Kecil dan Menengah (UMKM).
BMT memiliki potensi besar turut serta mewujudkan sektor UMKM yang kuat. Secara karakteristik, keberadaan lembaga keuangan ini memiliki kebersenyawaan yang erat dengan sektor usaha, karena target dan sasaran BMT serta skala usahanya memiliki orientasi pembiayaan sektor mikro. Selain itu aset nasional BMT juga telah mencapai Rp 4,7 trilliun, dengan jumlah pembiayaan Rp 3,6 trilliun. Sedangkan lembaga zakat dalam hal ini BAZNAS, juga memiliki potensi yang sama. Namun, dana ZIS ini nampaknya belum disalurkan secara maksimal. Efektivitas penyaluran dana ZIS tahun 2014 sekitar 67,50 % , sedangkan tahun 2015 ini hanya 26,91%.
Atas hal ini, perlu adanya sinergitas kedua lembaga ini dalam bentuk kerjasama penyaluran dana ZIS agar maksimal. BAZNAS memiliki dana ZIS yang cukup besar, dan BMT juga memiliki program pembiyaaan mikro dan dana ZIS. Mekanismenya adalah BAZNAS menyalurkan dana untuk mayarakat miskin dan pelaku usaha mikro (kecil dan menengah) melalui BMT agar lebih terkontrol. BMT dalam menyalurkan dana ZIS tersebut dengan mekanisme â€œACTORSâ€ melalui  5 tahapan, yakni, pemberian dana ZIS untuk masyarakat miskin, qardul , bagi hasil, return, saving.
â€œStudentâ€™s Passion on Entrepreneurship (Studi Pada Mahasiswa Fakultas Ekonomi dan Bisnis Islam, IAIN Purwokerto)
Authors: Socha Sochimin
Published: November 2018

ABSTRACT
The aim of this study was to determine whether is  minimum of one variables influence from personality, family environment, opportunities, and incomes towards entrepreneurship interest student of the Faculty of Economics and Business of Islam, IAIN Purwokerto. Data used in this research is primary data through questionnaire, interview, and observation. The sampling technique is Purposive Sampling which is calculated with Slovin formulaâ€™s. The data analysis by quantitative with multiple linear regression method using SPSS 17.0 for windows.
The result of this study shows that personal variable, famlily environment, opportunities, and incomes is take effect simultaneously on entrepreneurship interest student of the Faculty of Economics and Business of Islam, IAIN Purwokerto. Partially, personal variable, and opportunities isnâ€™t effect to entrepreneurhip interest student the Faculty of Economics and Business of Islam, IAIN Purwokerto, and family environment variable, and incomes is take effect to entrepreneurhip interest student the Faculty of Economics and Business of Islam, IAIN Purwokerto. The result of this reseach in a determination coefficient amont 0,79%, the mean is 79% variation entrepreneurship interest student the Faculty of Economics and Business of Islam, IAIN Purwokerto can be explain with independent variable which cover personality, family environment, opportunities, and incomes, and the rest explained by other varibles outside the regression model.
Keywords : Personality, Family Environment, Opportunities, Incomes, Entrepreneurship Interest, Entrepreneurship.
Assessment of sedation after intranasal administration of midazolam and midazolam-butorphanol in cockatiels (Nymphicus hollandicus)
Authors: Doss Grayson A. , Fink Dustin M. , Mans Christoph
Published: November 2018

OBJECTIVE To compare sedation in cockatiels (Nymphicus hollandicus) after intranasal administration of midazolam and midazolam-butorphanol.

ANIMALS 9 healthy adult cockatiels.

PROCEDURES A randomized, controlled, blinded, complete crossover study was conducted. Birds were assigned to 3 treatment groups. Midazolam (3 mg/kg), midazolam-butorphanol (3 mg/kg for each drug), or sterile saline (0.9% NaCl) solution (control treatment) was administered intranasally. Sedation quality was assessed at 3 time points by use of eye and body position; response to visual, auditory, and tactile stimulation; and response during manual restraint on the basis of eye position and struggling intensity. To evaluate attenuation of the manual restraint–induced stress response, heart rate, respiratory rate, and cloacal temperature were measured over a 15-minute period. Treatments were repeated after a minimum washout period of 7 days.

RESULTS Median onset of first sedation effects was 85 seconds (range, 60 to 120 seconds) for midazolam and 90 seconds (range, 45 to 180 seconds) for midazolam-butorphanol. Midazolam-butorphanol resulted in significantly less vigorous struggling during restraint than did midazolam or the control treatment. Heart rate did not differ significantly among treatments. The stress-induced increase in respiratory rate was significantly attenuated by midazolam and midazolam-butorphanol, whereas the increase in cloacal temperature was not attenuated by midazolam or midazolam-butorphanol.

CONCLUSIONS AND CLINICAL RELEVANCE Intranasal administration of midazolam and midazolam-butorphanol resulted in a rapid onset of sedation in cockatiels. Midazolam-butorphanol resulted in deeper sedation in both restrained and unrestrained birds than did midazolam alone. Midazolam and midazolam-butorphanol both provided safe and effective sedation in cockatiels.
Sedative and cardiopulmonary effects of buccally administered detomidine gel and reversal with atipamezole in dogs
Authors: Kasten Jennifer I. , Messenger Kristen M. , Campbell Nigel B.
Published: November 2018

OBJECTIVE To evaluate hemodynamic, respiratory, and sedative effects of buccally administered detomidine gel and reversal with atipamezole in dogs.

ANIMALS 8 adult purpose-bred dogs.

PROCEDURES Arterial and venous catheters were placed. Baseline heart rate, respiratory rate, cardiac output (determined via lithium dilution with pulse contour analysis), oxygen delivery, systemic vascular resistance, arterial blood gas values, and sedation score were obtained. Detomidine gel (2.0 mg/m2) was administered on the buccal mucosa. Cardiopulmonary data and sedation scores were obtained at predetermined times over 180 minutes. Atipamezole (0.1 mg/kg) was administered IM at 150 minutes. Reversal of sedation was timed and scored. Data were analyzed with an ANOVA.

RESULTS Compared with baseline values, heart rate was lower at 45 to 150 minutes, cardiac output and oxygen delivery were lower at 30 to 150 minutes, and systemic vascular resistance was increased at 30 to 150 minutes. There were no significant changes in Paco2, Pao2, or lactate concentration at any time point, compared with baseline values, except for lactate concentration at 180 minutes. All dogs became sedated; maximum sedation was detected 75 minutes after administration of detomidine. Mean ± SD time to recovery after atipamezole administration was 7.55 ± 1.89 minutes; sedation was completely reversed in all dogs. No adverse events were detected.

CONCLUSIONS AND CLINICAL RELEVANCE Buccally administered detomidine gel was associated with reliable and reversible sedation in dogs, with hemodynamic effects similar to those induced by other α2-adrenoceptor agonists. Buccally administered detomidine gel could be an alternative to injectable sedatives in healthy dogs.
Effect of a constant rate infusion of remifentanil hydrochloride on left ventricular systolic and diastolic function in propofol-anesthetized dogs
Authors: Marques Marcel G. , Cancelli Carlos H. B. , Fernandes Carollina M. S. , Games Bruna M. M. , Floriano Beatriz P. , Perri Silvia H. V. , Sousa Marlos G. , Ferreira Wagner L. , Santos Paulo S. P.
Published: November 2018

OBJECTIVE To assess the effects of a constant rate infusion (CRI) of remifentanil hydrochloride on left ventricular systolic and diastolic function in healthy propofol-anesthetized dogs.

ANIMALS 6 healthy Beagles.

PROCEDURES Each dog underwent 2 experimental treatments separated by a 7-day interval. In 1 treatment, anesthesia was induced with propofol and maintained with a CRI of propofol (0.6 mg/kg/min); dogs also received a CRI of saline (0.9% NaCl) solution. In the other treatment, anesthesia was similarly induced and maintained with propofol; dogs also received a CRI of remifentanil (0.3 μg/kg/min). Doppler echocardiographic and hemodynamic variables of interest were determined at baseline (before anesthesia) and at 20, 40, and 60 minutes following the simultaneous start of the 2 CRIs of each treatment; all CRIs were administrated for 60 minutes.

RESULTS For the 2 treatments, end-diastolic and end-systolic volume indices did not differ from baseline or at any time point. Peak tissue Doppler-derived mitral annulus systolic velocity decreased from baseline with both treatments; however, no differences were found between treatments at any time point. Mean arterial blood pressure decreased similarly with both treatments. Heart rate and Doppler-determined cardiac index decreased significantly with the propofol-remifentanil treatment, compared with findings for the propofol-saline solution treatment. For the propofol-remifentanil treatment, the ratio of peak velocity flow in early diastole to that in late diastole remained > 1.80, whereas the ratio of early to late Doppler-derived mitral annulus velocity had a normal relaxation pattern.

CONCLUSIONS AND CLINICAL RELEVANCE Results of this study indicated that a CRI of remifentanil administered along with a CRI of propofol does not impair left ventricular systolic and diastolic function in healthy dogs.
Activation of chicken macrophages during in vitro stimulation and expression of immune genes
Authors: Jin Xing , Zhang Xu , Li Jinchun , Yu Weiyi , Chen Fangfang
Published: November 2018

OBJECTIVE To characterize activation and expression of immune genes of chicken macrophages after in vitro stimulation with lipopolysaccharide (LPS) and mouse erythrocytes.

ANIMALS Five 15-day-old chickens and 2 BALB/c mice.

PROCEDURES Macrophages were extracted from chicken bone marrow or peripheral blood and then stimulated with cytokines secreted from cell lines L929 and HD11. Stimulated chicken macrophages were further cocultured with LPS or mouse erythrocytes, and gene transcription of some distinctive cytokines was detected by use of a real-time PCR assay.

RESULTS Morphological features and phagocytic function of macrophages were characterized. Activated macrophages had an elongated shape with a large cell nucleus, and they had phagocytic function. Distinctive genes encoding the surface marker gene CD11b were identified; high quantities of CD11b were transcribed. Relative transcription of chicken genes BF and BL in mature cells cocultured with both stimuli was lower than for control cells. However, the quantity of genes encoding M1- or M2-distinctive cytokines (interleukin [IL]-1β, IL-10, IL-12, inducible nitric oxide synthase, tumor necrosis factor-α, and transforming growth factor-β) that were transcribed differed significantly between stimulation with LPS and mouse erythrocytes.

CONCLUSIONS AND CLINICAL RELEVANCE Chicken macrophages were differentially stimulated by LPS and mouse erythrocytes, which suggested that in vitro stimulation can distinctly influence the transcription and expression of immune genes of chicken macrophages.
Effect of pneumoperitoneum with warmed humidified or standard-temperature carbon dioxide during laparoscopy on core body temperature, cardiorespiratory and thromboelastography variables, systemic inflammation, peritoneal response, and signs of postoperative pain in healthy mature dogs
Authors: Scott Jacqueline E. , Singh Ameet , Valverde Alexander , Blois Shauna L. , Foster Robert A. , Kilkenny Jessica J. , Linden Alex zur
Published: November 2018

OBJECTIVE To evaluate effects of pneumoperitoneum created with warmed humidified CO2 (WHCO2) during laparoscopy on core body temperature, cardiorespiratory and thromboelastography variables, systemic inflammation, peritoneal response, and signs of postoperative pain in healthy mature dogs.

ANIMALS 6 mature purpose-bred dogs.

PROCEDURES In a randomized crossover study, each dog was anesthetized twice, and pneumoperitoneum was created with standard-temperature CO2 (STCO2; 22°C and 0% relative humidity) and WHCO2 (37°C and 98% relative humidity). Data were collected during each procedure, including core body temperature, cardiorespiratory and thromboelastography variables, and inflammatory biomarkers. Peritoneal biopsy specimens were collected and evaluated with scanning electron microscopy. Dogs were assessed for signs of postoperative pain.

RESULTS Mean core body temperature was significantly lower (35.2°C; 95% confidence interval, 34.5° to 35.8°C) with WHCO2 than with STCO2 (35.9°C; 95% confidence interval, 35.3° to 36.6°C) across all time points. Cardiac index increased during the procedure for both treatments but was not significantly different between treatments. Thromboelastography variables did not differ significantly between treatments as indicated by the coagulation index. Subjective evaluation of peritoneal biopsy specimens revealed mesothelial cell loss with STCO2. There was no significant difference in circulating C-reactive protein or interleukin-6 concentrations. There was a significant increase in the number of postoperative pain scores > 0 for the WHCO2 treatment versus the STCO2 treatment.

CONCLUSIONS AND CLINICAL RELEVANCE Analysis of these data suggested that effects on evaluated variables attributable to the use of WHCO2 for creating pneumoperitoneum in healthy mature dogs undergoing laparoscopy did not differ from effects for the use of STCO2.
Study of the Effect of Sustainable Architecture on the Design of Residential Buildings (Case Study: Qazvin Pardis Complex)
Authors: Mohammadian Zeynab , Shahbazi Majid
Published: November 2018

Housing is a widespread and complex issue with a variety of dimensions. First, housing was considered as a physical location and as a shelter and basic necessity of the households, but today the concept of dwelling as the place that provides all the services and facilities necessary for a better life of the family has been created. One of the issues discussed at many conferences and in general in the scientific community is the definition of sustainability in the psychological point of view, along with the ways to introduce this concept into the architecture and human habitat environments. This research first begins with the main question about how the concept of sustainability can be found within the scope of housing. Then existing resources search is done and accessible projects are analyzed and the weaknesses and strengths of traditional architecture and contemporary architecture are compared. Finally, the relationship between the definitions of three concepts: dwelling, sustainable design and traditional Iranian architecture was discussed. At the end, the sustainable design that is also appropriate to the Iranian culture was presented.