bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALISIS CUSTOMER JOURNEY PENGGUNA NOABIKE
Authors: Darman Florentinus , Ciptosari Fitri , Wadhi Yohanes Paulus Hanny
Published: November 2024

Penelitian ini bertujuan untuk menganalisis customer journey pengguna aplikasi Noabike di Labuan Bajo, dengan fokus pada peningkatan pengalaman pengguna dan promosi transportasi ramah lingkungan. Noabike adalah layanan penyewaan kendaraan listrik berbasis aplikasi yang berperan penting dalam mendukung mobilitas berkelanjutan di daerah wisata. Melalui pendekatan kualitatif penelitian ini mengeksplorasi lima tahap utama dalam customer journey: Awareness, Interest/Consideration, Decision, Retention, dan Advocacy. Wawancara mendalam dilakukan terhadap 10 pengguna dengan latar belakang yang beragam. Hasil penelitian menunjukkan bahwa media sosial dan word-of-mouth memainkan peran penting dalam meningkatkan kesadaran pengguna, sementara kemudahan akses, keberlanjutan, dan pengalaman pengguna yang positif menjadi faktor kunci dalam mempertahankan loyalitas pelanggan. Strategi pemasaran digital yang kuat, program loyalitas, serta promosi khusus terbukti efektif dalam meningkatkan retensi dan advokasi. Penelitian ini memberikan wawasan tentang pengembangan layanan transportasi berkelanjutan di kawasan wisata dan mendukung upaya global untuk mengurangi emisi karbon.
EXAMINING MARKET ACCEPTANCE
Authors: Sondak Michael Ricky
Published: November 2024

This research endeavors to ascertain whether family businesses employ new product development as a strategy that is well received by the market. This qualitative research examined the food and beverage family business in Surabaya. Data was collected from credentialed persons or expertise via the use of purposive sampling. Interviews served as the primary method of data collection. The present study examines the experiences of family business proprietors in the food and beverage industry who, in response to ineffective marketing strategies, initiated the creation of innovative products. This study emphasizes sensory enjoyment, economic value, and brand trust in product development.
Economic Potential of Solar Projects in India: Assessing Levelized Cost of Electricity andPayback Period withVariations in PV Module Efficiency and Solar Irradiation
Authors: Agrawal Vibhor
Published: November 2024

India is endowed with vast solar resources, with about 5,000 trillion kWh per year of energy incident over India’s land area, with most parts receiving 4-7 kWh per sqm per day. The National Institute of Solar Energy (NISE) has assessed the country’s solar potential to be about 748 GW. The government is bullish on realizing this solar potential, setting out ambitious targets to install 500 GW of non-fossil fuel capacity by 2030, with Solar projects contributing a major chunk of it. Reports suggest that investments up to $294bn would be required to meet India’s solar and wind targets. However, this capital expenditure can be reduced or controlled by deploying our solar projects prudentially. This paper intends to quantify the effect of variations in Solar PV module efficiency due to varying technology and changes in solar irradiation according to differing geographies on the cost-effectiveness of Solar projects through the calculation of the Payback period and Levelized Cost of Electricity for Solar PV projects in different parts of India. Comparison of these techno-economic factors will aid policymakers and project developers in decision-making and deploying their resources to achieve maximum financial output. The results reveal that higher module efficiency and greater solar irradiation significantly bring down the cost of Solar projects, bringing it even below the global average LCOE of solar PV of 49$/MWh for higher efficiencies and reducing the payback period to as low as shorter than 5 years. Therefore, this paper aims to provide valuable insights to the policymakers and investors working in the solar energy sector in India to help build a clean, secure, and resilient energy future for India
Exploring the Fundamentals of Bilirubinometry: Methods of Assessment, Timely Monitoring, and Intervention in Neonatal Jaundice with Integrated Phototherapy Solutions—A Review
Authors: Badamasi Salihu , Ihebuzo Ndubuka G. , Udah KI Nkuma- , Obichere J.C
Published: November 2024

A frequent ailment in infants, neonatal jaundice is characterized by high bilirubin levels and yellowing of the skin and eyes. It needs to be carefully managed to avoid serious consequences like kernicterus. The principles of bilirubinometry are examined in this review paper, with particular attention paid to different evaluation techniques, the value of prompt monitoring, and modern intervention approaches. Newborns may find it uncomfortable to undergo intrusive blood drawing as part of traditional bilirubin measurement methods. Transcutaneous bilirubinometry (TcB), on the other hand, provides a non-invasive substitute that improves monitoring effectiveness and lessens patient pain. The mainstay of care for newborn jaundice is still phototherapy, which uses light to change bilirubin into a form that is easier to excrete. The efficacy and safety of phototherapy have been enhanced by recent developments, especially about LED-based technology. The evaluation also looks at integrated phototherapy options that optimize therapeutic results and improve neonatal safety by combining automated treatment modifications with real-time bilirubin monitoring. To improve neonatal health outcomes and lessen difficulties related to hyperbilirubinemia, this review emphasizes the significance of timely and effective care of neonatal jaundice by synthesizing existing achievements and highlighting the incorporation of technology innovations
Study The Impact of Bologna track on Student`s Following and Communication with Teachers At Imam Jaafar Alsadiq University
Authors: Alrobaiei Abduljaleel Mohammed Hamad
Published: November 2024

The current research aims to study if the Bologna processhelps the students follow and communicate with teachersaccording to the openions of students of the Technical College at Imam Ja’far Alsadiq University (Ijsu) - Baghdad - Iraq, the research sample consisted of (109) male and female students from the Department of Communications Technology Engineering, and a questionnaire was prepared for that consisted of onequestion, and the indicators of their validity and stability were verified, then the data were processed statistically using the statistical SPSS computer program, and the results indicated that the application of the Bologna processincreases the students` learning proficiency.
Solar irrigation system: Analysis of the solution for livestock production in North Cameroon
Authors: Mfewou Abdoulay , Njankouo Abdoulay Nsangou , Tsafack Ornella
Published: November 2024

This article examines the impact of implementing a solar irrigation system on livestock production in North Cameroon, a region marked by climatic challenges and increasingly dry conditions with 600 to 1,200 mm of rainfall per year and temperatures between 30°C and 40°C. Livestock farmers in the region rely heavily on natural pastures and forage crops to feed their livestock, but these resources are insufficient during periods of drought. The area is home to around 2 million head of cattle, with an estimated 500,000 to 700,000 head of sheep and 300,000 to 500,000 head of goats. Our methodology involved a comparative before-and-after analysis, where data on crop yields, pasture quality and animal performance were collected. Statistical simulation was used to assess improvements in pasture biomass, forage yield and animal performance. The results show significant improvements if the solar irrigation system is installed, with: a 30% increase in biomass; a 50% increase in forage yield with a 16.7% gain in animal weight; a 20% increase in milk production; a 30% reduction in forage procurement costs; and a 33.3% increase in income generated. These results indicate that solar irrigation will have a positive impact on farm productivity and profitability. The installation of a solar irrigation system in Northern Cameroon represents a sustainable and economically viable solution for improving livestock production in a region vulnerable to drought.In sub-Saharan Africa, solar irrigation systems have been successfully implemented in several countries, including Kenya, Ethiopia, Mali and Burkina Faso. These projects have demonstrated the viability of this technology in semi-arid and arid environments, with notable improvements in agricultural production and water management. The climatic and geographical conditions in Northern Cameroon are similar to those in the regions where solar irrigation systems have been tested.
Investigation of the Physicochemical Behaviour of Homoeopathic Dilutions of Glycerol (Glycerinum) at the Temperatures (293.15 - 318.15) K: Volumetric, Acoustic and ViscometricStudy
Authors: Nain Anil Kumar , . Soumya , Nayak Debadatta
Published: November 2024

The physicochemical studies of homoeopathic medicines provide better understanding regarding the presence and mechanism of their action in ultra-dilutions. The physicochemical behaviour of glycerol dilutions homoeopathic dilutions has been investigated from the measurements of densities, , ultrasonic speeds, u and viscosities,  of pure ethanol control (91% ethanol in water) and 33 dilutions of glycerol dilutions of potencies ranging from 1C to 200C at ambient temperatures and atmospheric pressure. From the experimental data, a number of physicochemical parameters, viz., the isentropic compressibilities, s , intermolecular free length, Lf , acoustic impedance, Z, relative association, RA, relaxation time, , ultrasonic absorption, /f 2 , pseudoGrüneisen parameter, , deviations in isentropic compressibility, s , deviations in intermolecular free length, Lf , deviations in acoustic impedance, Z, deviations in viscosity,  and deviations in pseudo-Grüneisen parameter, have been evaluated. These parameters showed diverse behaviour at certain potencies of these homoeopathic dilutions. The results have been qualitatively discussed in terms of prevailing interactions of these glycerol dilutions dilutions. The results indicated that that even in extreme dilutions (50C, 110C, 150C and 160C) the molecules of glycerol dilutions may be present in these homoeopathic formulations
Flexural & Compressive Strength Behaviour of Lowweight Engineered Timber Slab(ETS) composed of crack filler, wood adhesive & Saw dust
Authors: Ihemegbulem Ezekiel. O. , Ogbonna N.S.M.
Published: November 2024

This study presents the Compressive & Flexural Strength performance of Low-weight Engineered Timber Slab(ETS) composed of wood adhesive, Saw dust, & crack filler. It provides empirical data on the flexural and compressive properties of engineered timber slab(ETS), which is an element of wood adhesive(WA), sawdust(SD), crack filler(CF). SD gave values of 562.3/m3, 0.67, 39.66%, 2.85, 1.2 and 2.98 for mean bulk density, mean specific gravity, mean water absorption, finess modulus, coefficient of curvature (Cc) and uniformity (Cu). Batching was done by volume by virtue of the low density of the component materials (SD & CF). The component materials were manually mixed. A total of twelve (12) cubes of size 150 x 150 x 150mm, were produced from mix ratios 0.5:0.5:2 & 0.5:0.75:2(WA : CF : SD) for compressive strength test. The above mix ratios were adopted based on the light-weight nature & high rate of water absorption of the component materials. A total of Twenty (20) slabs of size 300 x 300 x 100mm, 300 x 300 x 125mm, 300 x 300 x 150mm, 300 x 300 x 175mm and 300 x 300 x 200mm were cast for flexural strength of slab. Twenty(20) slabs were produced for with slab thickness of 100mm, 125mm, 150mm, 175mm and 200mm using the mix ratios 0.5:0.5:2 & 0.5:0.75:2(WA:CF:SD) respectively. the mean values of the compressive strength, flexural strength and deflection were 14.9MPa & 15.78MPa, 5.06MPa to 5.52MPa and 28.9mm to 86.5mm respectively
Limitations and Principles of Safety in the 3D Bioprinting Process
Authors: Mahmoudian Andisheh , Mahmoudian Kiana
Published: November 2024

The importance of biological printing is in tissue structures that imitate the micro and real environment of human tissues and organs. This is very important in medicinal tests and clinical tests. In biological printing, cells or molecules are printed directly on a substrate in a particular pattern so that the cells can be kept together and formed the required 3D structure. This technology is widely used in medical science, including tissue regeneration, diagnosis of drugs, tissue transplantation, cosmetic surgery, and more. In this study, we have tried to point out existing damage and safety tips in this technology. Studies show the challenges facing this technology, such as high clarity in cell construction, lack of mechanical resistance and adequate integration of bio -printing structures made with soft hydrogel, material printing speed, recurreability and cell preservation. Also, work safety instructions with bio -printers including personal hygiene, printer cleaning, work room cleaning, ventilation system, periodic medical tests for operators are provided. Bioprinting technology is developing and requires further research to remove restrictions and reduce risk management
Evaluating Solar Energy Solutions: Installation, Maintenance, and Economic Impact on Boarding Facilities
Authors: Panwar Shivam Singh
Published: November 2024

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PI Based Speed Control of Induction Motors Employing Model Predictive Flux Control
Authors: Prakash Shiv , Agrawal Dr. Deepak , Sonkar Dr. Shivkumar , Tyagi Nitin
Published: November 2024

Model-based predictive torque control is a new kind of MPC for AC motor drives that has drawn a lot of interest from the research community lately. When compared to conventional induction motor drive control strategies like Direct Torque Control and Field-Oriented Control, Maximum Power Take-off offers many benefits, including simpler implementation, the ability to incorporate multiple objectives into a single cost function, an optimization-based solution, and the ability to account for system constraints and nonlinearities. The torque and stator-flux magnitude reference values and their future values at the next sampling instant are where the costfunction errors lie. On the other hand, the cost-function might potentially include other goals. Using all of the permitted switching states, the induction motor drive mathematical model predicts the future values. This work also discusses about a novel approach Dynamic Speed Control of Induction Motors Employing Model Predictive Flux Control (MPFC) and Volts by Frequency (V/f) Techniques. The gate pulse control for two-level-threephase inverter at the AC side is controlled using proportional integral controller
The role of human resources management in raising the efficiency of health, safety and environment in the workplace
Authors: Abdulrahman Salaheddin Ali
Published: November 2024

The issue of human resources management, the physical and psychological work environment in order to provide health, safety and environment for the human element in the workplace, is an important part of the human resources management strategy, because this issue has a direct impact on the most important thing that a person has, which is his health and life, and at the same time it is of great economic importance for the organization and society, because the high rate of work injuries and diseases in organizations costs them huge amounts of money spent on treatment, in addition to the fact that it disrupts work in them. As for society, the increase in these expenses negatively affects the national product and leads to the loss of part of the country's productive capacity. The concept of human resources management is an activity that includes a set of technical and administrative works and procedures, concerned with studying the climatic and psychological conditions prevailing in the places where work is carried out within organizations in general and industrial organizations in particular, and designing specialized programs in order to control/remove the sources and causes of potential accidents and diseases that human resources may suffer from while performing their work, resulting from the nature of this work, or from the surrounding climatic and psychological conditions, in order to work on providing the means of protection capable of avoiding these risks and their negative effects on the safety and health of human resources in the workplace, or at least mitigating these effects, and creating a sound and healthy physical and psychological work environment and climate that protects these resources from any danger.
"Effect of surface treatment on the adhesive wear of low carbon steel"
Authors: BOUGHAITH NABEEL E S , ALKHUDHER TAREQ H A H
Published: November 2024

Wear is one of the problems that occur in the moving parts either by rolling or sliding. This work includes experimental study on the wear of low carbon steel. Three surface treatments were chosen these are cyaniding, solid carburizing and hard chrome plating. The wear test was made under dry contact condition for the treated and the untreated surfaces. A constant load and speed were used for two types of motion: sliding-rolling and pure rolling. An Amsler machine was used. The high carbon steel was chosen for making the upper specimen and the low carbon steel was chosen for making the lower specimen. The high carbon steel was hardened while the other was surface treated (carburizing, cyaniding). The hard chrome plating was also used to increase the surface hardness. It was noticed that increasing of surface hardness reduced the wear amount produced, and the cyaniding gave the highest resistance to wear whereas the hard chrome plating gave the lowest one, and the wear under pure rolling condition was small .It was found that the wear rate of treated surfaces is high in the first stage of the test then the rate decreases until it reaches a steady state and for both motions.[v]
Interactions between short and long noncoding RNAs
Authors: Ulitsky Igor
Published: May 2018

It is now evident that noncoding RNAs play key roles in regulatory networks determining cell fate and behavior, in a myriad of different conditions, and across all species. Among these noncoding RNAs are short RNAs, such as MicroRNAs, snoRNAs, and Piwi‐interacting RNAs, and the functions of those are relatively well understood. Other noncoding RNAs are longer, and their modes of action and functions are also increasingly explored and deciphered. Short RNAs and long noncoding RNAs (lncRNAs) interact with each other with reciprocal consequences for their fates and functions. LncRNAs serve as precursors for many types of small RNAs and, therefore, the pathways for small RNA biogenesis can impinge upon the fate of lncRNAs. In addition, lncRNA expression can be repressed by small RNAs, and lncRNAs can affect small RNA activity and abundance through competition for binding or by triggering small RNA degradation. Here, I review the known types of interactions between small and long RNAs, discuss their outcomes, and bring representative examples from studies in mammals.
Structural biology data archiving – where we are and what lies ahead
Authors: Kleywegt Gerard J. , Velankar Sameer , Patwardhan Ardan
Published: May 2018

For almost 50 years, structural biology has endeavoured to conserve and share its experimental data and their interpretations (usually, atomistic models) through global public archives such as the Protein Data Bank, Electron Microscopy Data Bank and Biological Magnetic Resonance Data Bank (BMRB). These archives are treasure troves of freely accessible data that document our quest for molecular or atomic understanding of biological function and processes in health and disease. They have prepared the field to tackle new archiving challenges as more and more (combinations of) techniques are being utilized to elucidate structure at ever increasing length scales. Furthermore, the field has made substantial efforts to develop validation methods that help users to assess the reliability of structures and to identify the most appropriate data for their needs. In this Review, we present an overview of public data archives in structural biology and discuss the importance of validation for users and producers of structural data. Finally, we sketch our efforts to integrate structural data with bioimaging data and with other sources of biological data. This will make relevant structural information available and more easily discoverable for a wide range of scientists.
Recent Progress on Stability and Passivation of Black Phosphorus
Authors: Abate Yohannes , Akinwande Deji , Gamage Sampath , Wang Han , Snure Michael , Poudel Nirakar , Cronin Stephen B.
Published: May 2018

From a fundamental science perspective, black phosphorus (BP) is a canonical example of a material that possesses fascinating surface and electronic properties. It has extraordinary in‐plane anisotropic electrical, optical, and vibrational states, as well as a tunable band gap. However, instability of the surface due to chemical degradation in ambient conditions remains a major impediment to its prospective applications. Early studies were limited by the degradation of black phosphorous surfaces in air. Recently, several robust strategies have been developed to mitigate these issues, and these novel developments can potentially allow researchers to exploit the extraordinary properties of this material and devices made out of it. Here, the fundamental chemistry of BP degradation and the tremendous progress made to address this issue are extensively reviewed. Device performances of encapsulated BP are also compared with nonencapsulated BP. In addition, BP possesses sensitive anisotropic photophysical surface properties such as excitons, surface plasmons/phonons, and topologically protected and Dirac semi‐metallic surface states. Ambient degradation as well as any passivation method used to protect the surface could affect the intrinsic surface properties of BP. These properties and the extent of their modifications by both the degradation and passivation are reviewed.
Quantitative Cryo‐Scanning Transmission Electron Microscopy of Biological Materials
Authors: Elbaum Michael
Published: May 2018

Electron tomography provides a detailed view into the 3D structure of biological cells and tissues. Physical fixation by vitrification of the aqueous medium provides the most faithful preservation of biological specimens in the native, fully hydrated state. Cryo‐microscopy is challenging, however, because of the sensitivity to electron irradiation and due to the weak electron scattering of organic material. Tomography is even more challenging because of the dependence on multiple exposures of the same area. Tomographic imaging is typically performed in wide‐field transmission electron microscopy (TEM) mode with phase contrast generated by defocus. Scanning transmission electron microscopy (STEM) is an alternative mode based on detection of scattering from a focused probe beam, without imaging optics following the specimen. While careful configuration of the illumination and detectors is required to generate useful contrast, STEM circumvents the major restrictions of phase contrast TEM to very thin specimens and provides a signal that is more simply interpreted in terms of local composition and density. STEM has gained popularity in recent years for materials science. The extension of STEM to cryomicroscopy and tomography of cells and macromolecules is summarized herein.
Modeling the complex etiology of holoprosencephaly in mice
Authors: Hong Mingi , Krauss Robert S.
Published: May 2018

Holoprosencephaly (HPE) is a common developmental defect caused by failure to define the midline of the forebrain and/or midface. HPE is associated with heterozygous mutations in Nodal and Sonic hedgehog (SHH) pathway components, but clinical presentation is highly variable, and many mutation carriers are unaffected. It is therefore thought that such mutations interact with more common modifiers, genetic and/or environmental, to produce severe patterning defects. Modifiers are difficult to identify, as their effects are context‐dependent and occur within the complex genetic and environmental landscapes that characterize human populations. This has made a full understanding of HPE etiology challenging. We discuss here the use of mice, a genetically tractable model sensitive to teratogens, as a system to address this challenge. Mice carrying mutations in human HPE genes often display wide variations in phenotypic penetrance and expressivity when placed on different genetic backgrounds, demonstrating the existence of silent HPE modifier genes. Studies with mouse lines carrying SHH pathway mutations on appropriate genetic backgrounds have led to identification of both genetic and environmental modifiers that synergize with the mutations to produce a spectrum of HPE phenotypes. These models favor a scenario in which multiple modifying influences—both genetic and environmental, sensitizing and protective—interact with bona fide HPE mutations to grade phenotypic outcomes. Despite the complex interplay of HPE risk factors, mouse models have helped establish some clear concepts in HPE etiology. A combination of mouse and human cohort studies should improve our understanding of this fascinating and medically important issue.
Holoprosencephaly: A clinical genomics perspective
Authors: Solomon Benjamin D. , Retterer Kyle , Juusola Jane
Published: May 2018

New and rapidly evolving technologies have dramatically impacted the practice of clinical genetics as well as broader areas of medicine. To illustrate this trend from the perspective of a clinical molecular laboratory, we briefly summarize our general experience conducting exome testing for patients with holoprosencephaly (HPE). Though these cases are not representative of HPE more generally (i.e., cases undergoing exome sequencing represent a skewed sample), results include a 22% positive rate from exome testing. Of interest, 29% of reported results involved genes not considered to be classic HPE genes, indicating more evidence that HPE may fall within the severe spectrum of many other genetic conditions.
Applying spatial–temporal image correlation to the fetal kidney: Repeatability of 3D segmentation and volumetric impedance indices
Authors: Gu Bonita , Stevenson Gordon N. , Ferreira Ana , Pathirana Sudeshni , Sanderson Jennifer , Henry Amanda , Alphonse Jennifer , Welsh Alec W.
Published: May 2018

Introduction

Spatiotemporal image correlation (STIC) can evaluate fetal renal impedance using four‐dimensional volumetric indices. We assessed repeatability of three‐dimensional kidney segmentation and the repeatability of the resultant indices.

Methods

In each of 57 healthy pregnant women, three renal artery pulsed‐wave Doppler (PWD) traces and three STIC volumes were acquired from the same fetal kidney and segmented by two observers. Vascularisation‐flow index (VFI) and fractional moving blood volume (FMBV) were calculated for every STIC frame and used to determine the volumetric pulsatility index (vPI), volumetric resistance index (vRI) and volumetric systolic/diastolic ratio (vS/D). Segmentation performance was assessed using Dice similarity coefficients (DSCs), Hausdorff distances, coefficient of variation (CoV) and the intraclass correlation coefficient (ICC). Intra/Inter volumetric index repeatability was assessed using ICCs.

Results

Forty‐eight cases (84%) provided full data. Mean intra‐ and interobserver DSCs were 0.90 and 0.81. Mean intra‐ and interobserver Hausdorff distances were 3.88 mm and 5.27 mm. Average kidney volumes for observers 1 and 2 were 9.88 mL and 8.54 mL (mean difference 16.1%). Mean intra‐observer volumetric CoVs were 5.3% and 8.1%. Intra‐ and interobserver ICCs for kidney volume (same STIC volume) were 0.97 and 0.85. When assessing volume variation between STIC volumes, intra‐observer ICC was 0.97. ICCs were 0.77–0.81 for VFI‐derived volumetric indices and 0.61–0.62 for FMBV‐derived indices; ICCs for all PWD indices were between 0.58 and 0.59.

Conclusions

Periodical variation in vascularity was demonstrated in the fetal kidney, and three‐dimensional segmentation was highly repeatable. Derived volumetric impedance indices show moderate variability but outperform corresponding two‐dimensional PWD indices in terms of reproducibility.
MaxSynBio: Avenues Towards Creating Cells from the Bottom Up
Authors: Schwille Petra , Spatz Joachim , Landfester Katharina , Bodenschatz Eberhard , Herminghaus Stephan , Sourjik Victor , Erb Tobias J. , Bastiaens Philippe , Lipowsky Reinhard , Hyman Anthony , Dabrock Peter , Baret Jean‐Christophe , Vidakovic‐Koch Tanja , Bieling Peter , Dimova Rumiana , Mutschler Hannes , Robinson Tom , Tang T.‐Y. Dora , Wegner Seraphine , Sundmacher Kai
Published: May 2018

A large German research consortium mainly within the Max Planck Society (“MaxSynBio”) was formed to investigate living systems from a fundamental perspective. The research program of MaxSynBio relies solely on the bottom‐up approach to synthetic biology. MaxSynBio focuses on the detailed analysis and understanding of essential processes of life through modular reconstitution in minimal synthetic systems. The ultimate goal is to construct a basic living unit entirely from non‐living components. The fundamental insights gained from the activities in MaxSynBio could eventually be utilized for establishing a new generation of biotechnological processes, which would be based on synthetic cell constructs that replace the natural cells currently used in conventional biotechnology.
A Metal–Organic Framework with Cooperative Phosphines That Permit Post‐Synthetic Installation of Open Metal Sites
Authors: Dunning Samuel G. , Nandra Gianne , Conn Adam D. , Chai Wenrui , Sikma R. Eric , Lee Ji Sun , Kunal Pranaw , Reynolds Joseph E. , Chang Jong‐San , Steiner Alexander , Henkelman Graeme , Humphrey Simon M.
Published: May 2018

PCM‐101 is a phosphine coordination material comprised of tris(p‐carboxylato)triphenylphosphine and secondary pillaring groups coordinated to [M3(OH)]5+ nodes (M=Co, Ni). PCM‐101 has a unique topology in which R3P: sites are arranged directly trans to one another, with a P⋅⋅⋅P separation distance dictated by the pillars. Post‐synthetic coordination of soft metals to the P: sites proceeds at room temperature to provide X‐ray quality crystals that permit full structural resolution. Addition of AuCl groups forces a large distortion of the parent framework. In contrast, CuBr undergoes insertion directly between the trans‐P sites to form dimers that mimic solution‐phase complexes, but that are geometrically strained due to steric pressure exerted by the MOF scaffold. The metalated materials are active in heterogeneous hydroaddition catalysis under mild conditions, yielding different major products compared to their molecular counterparts.
Enantioselective Synthesis of Vicinal All‐Carbon Quaternary Centers via Iridium‐Catalyzed Allylic Alkylation
Authors: Hethcox J. Caleb , Shockley Samantha E. , Stoltz Brian M.
Published: May 2018

The development of the first enantioselective transition‐metal‐catalyzed allylic alkylation providing access to acyclic products bearing vicinal all‐carbon quaternary centers is disclosed. The iridium‐catalyzed allylic alkylation reaction proceeds with excellent yields and selectivities for a range of malononitrile‐derived nucleophiles and trisubstituted allylic electrophiles. The utility of these sterically congested products is explored through a series of diverse chemo‐ and diastereoselective product transformations to afford a number of highly valuable, densely functionalized building blocks, including those containing vicinal all‐carbon quaternary stereocenters.
Margarines Produced From Rice Bran Oil and Fractionated Palm Stearin and Their Characteristics During Storage
Authors: Podchong Pawitchaya , Sonwai Sopark , Rousseau Dérick
Published: May 2018

Rice bran oil (RBO) usage in Southeast Asia is increasing. The purpose of this study was to incorporate RBO in margarine as a replacement for common oils such as soybean oil. The physicochemical properties of blends of RBO and fractionated palm stearin (FPS) at eleven different weight ratios (from 0:100 to 100:0) were characterized. Results showed that fat blends with ratios of 10:90, 20:80, and 30:70 RBO:FPS were semisolid at ambient temperature, with solid fat contents and a crystal morphology similar to commercial margarine fats. Blends containing ≤30% RBO were made into margarines and compared against commercial margarine over 8 weeks of storage. The margarine with a 20:80 RBO:FPS fat phase was stable against coalescence and phase separation while demonstrating acceptable spreadability and whippability at ambient temperature. Fat crystals in this blend were in the β′ polymorph at all time points during storage, which is a desired characteristic in margarine. This study showed that RBO may be effectively used for margarine production.
Rh(III)‐Catalyzed Phosphine Oxide Migration Reactions: Selective Synthesis of 3‐Phosphinoylindoles
Authors: Wang Chun‐Hai , Yang Shang‐Dong
Published: May 2018

3‐Phosphinoylindoles are important components of biological active natural products and materials in pharmaceuticals. Herein, a new approach for the synthesis of 3‐phosphinoylindoles has been established by a Rh(III)‐catalyzed cyclization from readily accessible (2‐azidostyryl)diphenylphosphine oxides. This intramolecular transformation occurs through a unique phosphine oxide group migration and offers a straightforward route to rebuild sp2 C−P bond and construct the indole ring in single step.
Altered resting‐state hippocampal and caudate functional networks in patients with obstructive sleep apnea
Authors: Song Xiaopeng , Roy Bhaswati , Kang Daniel W. , Aysola Ravi S. , Macey Paul M. , Woo Mary A. , Yan‐Go Frisca L. , Harper Ronald M. , Kumar Rajesh
Published: May 2018

Introduction

Brain structural injury and metabolic deficits in the hippocampus and caudate nuclei may contribute to cognitive and emotional deficits found in obstructive sleep apnea (OSA) patients. If such contributions exist, resting‐state interactions of these subcortical sites with cortical areas mediating affective symptoms and cognition should be disturbed. Our aim was to examine resting‐state functional connectivity (FC) of the hippocampus and caudate to other brain areas in OSA relative to control subjects, and to relate these changes to mood and neuropsychological scores.

Methods

We acquired resting‐state functional magnetic resonance imaging (fMRI) data from 70 OSA and 89 healthy controls using a 3.0‐Tesla magnetic resonance imaging scanner, and assessed psychological and behavioral functions, as well as sleep issues. After standard fMRI data preprocessing, FC maps were generated for bilateral hippocampi and caudate nuclei, and compared between groups (ANCOVA; covariates, age and gender).

Results

Obstructive sleep apnea subjects showed significantly higher levels of anxiety and depressive symptoms over healthy controls. In OSA subjects, the hippocampus showed disrupted FC with the thalamus, para‐hippocampal gyrus, medial and superior temporal gyrus, insula, and posterior cingulate cortex. Left and right caudate nuclei showed impaired FC with the bilateral inferior frontal gyrus and right angular gyrus. In addition, altered limbic‐striatal‐cortical FC in OSA showed relationships with behavioral and neuropsychological variables.

Conclusions

The compromised hippocampal‐cortical FC in OSA may underlie depression and anxious mood levels in OSA, while impaired caudate‐cortical FC may indicate deficits in reward processing and cognition. These findings provide insights into the neural mechanisms underlying the comorbidity of mood and cognitive deficits in OSA.
A comprehensive and perspective view of oncoprotein SET in cancer
Authors: Bayarkhangai Buuvee , Noureldin Suzan , Yu Liting , Zhao Na , Gu Yaru , Xu Hanmei , Guo Changying
Published: May 2018

SET is a multifunctional oncoprotein which is ubiquitously expressed in all kinds of cells. The SET protein participates in many cellular processes including cell cycle, cell migration, apoptosis, transcription, and DNA repair. Accumulating evidence demonstrates that the expression and activity of SET correlate with cancer occurrence, metastasis, and prognosis. Therefore, the SET protein is regarded as a potential target for cancer therapy and several inhibitors are being developed for clinical use. Herein, we comprehensively review the physiological and pathological functions of SET as well as its structure‐function relationship. Additionally, the regulatory mechanisms of SET at both transcriptional and posttranslational levels are also discussed.
Soluble fibrinogen‐like protein 2 ameliorates acute rejection of liver transplantation in rat via inducing Kupffer cells M2 polarization
Authors: Pan Guangrui , Zhao Zhengfei , Tang Chengyong , Ding Liuyue , Li Zhongtang , Zheng Daofeng , Zong Liang , Wu Zhongjun
Published: May 2018

Soluble fibrinogen‐like protein 2 (sFGL2) could ameliorate acute rejection (AR) in rat cardiac transplantation. However, the role of sFGL2 in AR of liver transplantation has not been addressed. In this study, we found that FGL2 was upregulated in rat orthotropic liver transplantation (OLT) models of tolerance and positive correlation with the frequency of M2 Kupffer cells (KCs). Gain‐of‐function experiments in vitro showed that sFGL2 promoted the secretion of anti‐inflammatory cytokines (IL‐10, TGF‐β) and the expression of CD206, and inhibited the activities of STAT1 and NF‐κB signaling pathway. Consistently, in vivo assays showed that adeno‐associated virus‐mediated FGL2 (AAV‐FGL2) transfer to recipients could ameliorate AR of rat OLT and induce KCs M2 polarization in allografts. Notably, we found that the recipients receiving transferred KCs from AAV‐FGL2‐treated allograft showed alleviated AR. Taken together, we revealed that sFGL2 ameliorated AR by inducing KCs M2 polarization.
FDA warns against underage use of JUUL, cracks down on sales
Authors: Knopf Alison
Published: May 2018

JUUL, an e‐cigarette device that delivers nicotine, was cited by the Food and Drug Administration (FDA) for targeting young people. In April, the FDA cited 40 retailers for violations relating to youth sales, announced that more retailers would be targeted, took action to examine the youth appeal of JUUL, took steps to foreclose online sales of JUUL to minors, and pledged to take further steps in a new effort to stop youth use of e‐cigarettes altogether.
The case of the unwanted crystal: a case of pediatric pulmonary Actinomyces Odonolyticus
Authors: Gray Ashley , Do Paul
Published: May 2018

Key Clinical Message

This case report is one of the only known cases of Actinomyces odontolyticus causing thoracic disease in an immunocompetent pediatric patient. This case also exemplifies how bronchoscopy was able to remove the nidus of infection and prevent the potential for significant morbidity associated with a lobectomy.
cube berlin … das schlaueste Gebäude Europas, ein Juwel aus 100 % Glas
Authors: Lutz Martin , Fauth Joachim , Dederichs Klaus , Buchholz Ralf
Published: May 2018

Auf 42,5 × 42,5 × 42,5 Metern bietet der cube berlin Platz für modernste und hochflexible Büroflächen. Auf dem einzigartigen Bauplatz in Berlin, dem Washington‐Platz, zwischen Hauptbahnhof und Bundeskanzleramt, entsteht ein auf allen Seiten freistehendes ganzgläsernes Gebäude. Der cube berlin, dessen Entwurf von 3XN Architekten als Sieger aus einem europäischen Wettbewerb hervorgegangen ist, gilt derzeit, aufgrund seiner maximalen Digitalisierung, als das zukünftig schlaueste Gebäude Europas. Der Bauherr, die CA Immo Deutschland GmbH, hat ein spektakuläres Bürogebäude entwickelt, in welchem für jedes Bürogeschoss große Austrittsbalkone für die Nutzer angeboten werden. Ein Juwel aus Glas, ohne geschlossene Anteile in der Fassade und dennoch ist der EnEV‐Nachweis gelungen.
Herausforderungen bei der Realisierung des Museum of Fine Arts, Houston
Authors: Schieber Roman , Fildhuth Thiemo , Oppe Matthias , Helbig Thorsten
Published: May 2018

Nach einem Entwurf von Steven Holl entstehen derzeit zwei neue Gebäude auf dem Campus des Museum of Fine Arts in Houston, Texas. Das Projekt mit einer Bausumme von 350 Mio. USD gliedert sich in zwei Bauabschnitte; der sogenannten „Glassell School“ und dem „Kinder Building“. Die Herausforderung bei der Planung des ersten Bauabschnitts bestand in erster Linie in der reduzierten Architektursprache, die die pure Materialität von Beton und großformatigen transluzenten Gläsern zur Schau stellt und dabei jedes Rahmenprofil und sichtbare Detail dem architektonischen Konzept in die Quere käme. Die Fenster mit Abmessungen von bis zu 8 m × 6 m müssen Windlasten von bis zu 120 psf / 5,7 kN/m2 Stand halten. Der eigentliche Museumsneubau wird mit über 1000 ca. 6 m langen transluzenten Glasröhren eingekleidet. Neben der Realisierung der schwerkraftgebogenen Gläser war die punktgenaue Steuerung des Tageslichts im Inneren des Museums die größte Herausforderung.
Innovative Bautechnik im Herzen Asiens – die EXPO 2017 in Astana, Kasachstan
Authors: Winterstetter Thomas , Berger Radu , Starz Florian , Bechmann Roland , Sobek Werner
Published: May 2018

Im Juni 2017 öffnete die EXPO‐Weltausstellung in Astana, der Hauptstadt von Kasachstan. Die Werner Sobek Stuttgart AG (WSS) war verantwortlich für die Tragwerks‐ und Fassadenplanung der zentralen Bereiche des EXPO‐Geländes, das von ASGG Adrian Smith Gordon Gill Architects aus Chicago entworfen wurde. Neben diversen, organisch geformten Länder‐ und Themen‐„Pavillions“ ist der Kasachstan‐Pavillion ein Meilenstein der Baukunst: Ein riesiges kugelförmiges, neungeschossiges Gebäude mit 80 m Durchmesser, dessen Außenhaut aus sphärisch geformtem Isolierglas besteht. Die EXPO steht ganz im Zeichen nachhaltiger Energie, daher sind seilnetz‐gelagerte Photovoltaik‐Verglasungen und gebäudeintegrierte Windturbinen Bestandteil dieses innovativen Bauwerks.
Filterfabrik Wilsdruff – Beispiel der Anwendung struktureller PVB‐Folien im Fassadenbereich
Authors: Kothe Michael
Published: May 2018

Verbundsicherheitsgläser (VSG) mit strukturellen PVB‐Folien eignen sich für eine Vielzahl herausfordernder Anwendungen im Objekt‐ und Fassadenbau. Das Erreichen relevanter Sicherheitseigenschaften in Verbindung mit Vorteilen in verarbeitungstechnischer, als auch in ökonomischer Sicht ermöglicht oftmals einen sinnvolleren Einsatz, als die Verwendung entsprechender Gläser mit Ionomer‐Zwischenschichten. Das Beispiel des Neubaus der Filterfabrik Wilsdruff stellt den erstmaligen Einsatz großformatiger VSG mit struktureller PVB‐Folie unter Ansatz des Schubverbunds in Deutschland dar. Sowohl die Scheibengrößen von 7,25 m × 2,40 m als auch die zweiseitige Lagerung der Fassadenscheiben sind außergewöhnlich und in dieser Kombination einmalig in Deutschland. Dabei zeigt dieses Projekt Möglichkeiten des Einsatzes derartiger VSG und hilft somit die Akzeptanz bei Architekten, Planern und Bauherren zu erhöhen.
Neue Anwendungsbereiche für transparente Silikonklebungen im Glasbau
Authors: Sonntag Liana , Teich Martien , Camacho Sergio , Albiez Matthias , Sitte Sigurd , Ummenhofer Thomas
Published: May 2018

Im konstruktiven Glasbau wird die Transparenz alleine durch die Verbindungselemente behindert. Punkthalter stören das Erscheinungsbild dabei am wenigsten, allerdings muss das Glas in der Regel durchbohrt werden. Dies kann zu Spannungsspitzen im Glas und Dichtigkeitsproblemen bei Isolierglas führen. Um diesen Nachteilen entgegenzuwirken, wurde ein transparenter Klebstoff entwickelt, mit dem kreisrunde Punkthalter auflaminiert werden können: das Transparent Structural Silicone Adhesive (TSSA). Dieser Beitrag beschreibt Grundlagenuntersuchungen zu rechteckigen TSSA‐Verbindungen, wobei die Klebefläche der experimentellen Untersuchungen stark von der ursprünglichen runden Geometrie des Punkthalters abweicht. Die Übertragbarkeit der Festigkeitskennwerte und Versagensmodelle für die Dimensionierung von Klebungen in anderen Anwendungsbereichen wird untersucht.
Messungen von Oberflächentemperaturen an PV‐integrierten Dünnschichtmodulen
Authors: Nehring Gordon , Siebert Geralt , Botz Martin
Published: May 2018

Für die Bemessung von tragenden Glaselementen und deren konstruktiven Lagerungsvarianten unter Temperaturänderungen inklusive gleichzeitig wirkenden Windlasten (3 s Windböe) sind aktuell kaum bemessungsrelevante Temperaturbereiche bekannt. Von 1999 bis 2000 wurden bereits Temperaturmessungen für dickwandige emaillierte Verbundgläser in Korrelation zur Windgeschwindigkeit und Solarintensität durchgeführt, allerdings in Südausrichtung (Neigungswinkel 0°, 45°und 90°) in offenen und geschlossenen Kästen [1]. Um zusätzlich die Ost‐ und Westausrichtung zu berücksichtigen, wurden an PV‐integrierten Dünnschichtmodulen sowie klaren Referenzproben Daten der Oberflächentemperaturen korreliert mit der Solarintensität und Windgeschwindigkeit in Freibewitterung (Standort Neubiberg) neu erfasst.
Doppelringbiegeversuche an Glasplatten aus Kalk‐Natron‐Silikatglas bei erhöhten Temperaturen bis in den Transformationsbereich
Authors: Pourmoghaddam Navid , Dittmann Swantje , Schneider Jens
Published: May 2018

In diesem Beitrag werden Untersuchungen zur Eignung des Doppelringbiegeversuchs an Proben mit kleinen Prüfflächen nach DIN EN 1288‐5 zur Untersuchung der Biegezugfestigkeit von thermisch entspanntem Kalk‐Natron‐Silikatglas bei erhöhter Temperatur bis in den Bereich der Glasübergangstemperatur vorgestellt. Hierzu wurden Doppelringbiegeversuche an runden Glasplatten aus Kalk‐Natron‐Silikatglas in einem Temperaturbereich von 23 °C bis 650 °C in einem Ofen durchgeführt. Das mechanische Verhalten des Glases während der Versuche in diesem Temperaturbereich wurde mithilfe der Finiten Elemente Methode (FEM) simuliert, wobei das viskoelastische Materialverhalten sowie die Strukturrelaxation mit Hilfe des Modells von Narayanaswamy berücksichtigt wurden. Die Ergebnisse zur Biegezugfestigkeit werden hierauf basierend ausgewertet und erläutert.
Der Traum vom Licht – Tageslicht, Ausblick und Energieeffizienz mittels Fluid Flow Glazing
Authors: Pfanner Daniel , Vatashka Teodora , Münzinger Astrid , Esiyok Ümit , Leykam Daniel
Published: May 2018

This article is not available for publication.
Fassadenelemente einer Bioenergiefassade – Entwicklung eines Prototyps
Authors: Aßmus Elisabeth , Weller Bernhard , Walter Frank , Kerner Martin
Published: May 2018

Im Rahmen der Internationalen Bauaustellung wurde 2013 in Hamburg eine Bioenergiefassade an einem Wohnhaus installiert und seitdem erfolgreich betrieben. Anhand dieses Projektes wurde erstmals der Nachweis erbracht, dass in speziellen plattenförmigen Fassadenelementen, sogenannten Photobioreaktoren, über die einfallende Solarstrahlung Wärme und Algen Biomasse erzeugt werden kann. Das Forschungsteam FABIG – ein Verbundprojekt mit der Technischen Universität Dresden, ADCO Technik GmbH, Arup Deutschland GmbH und SSC GmbH ‐ entwickelte diese zu geschosshohen, plattenförmigen Fassadenelementen aus Glas so weiter, dass sie nunmehr in die Primär‐ und Sekundarfassade integriert werden können. Das Team erarbeitete zunächst Konstruktionskonzepte für einen geklebten plattenförmigen Photobioreaktor und untersuchte die Klebkonstruktion, die haustechnische Anbindung sowie die Fassadenintegration näher. Der Beitrag beschreibt den Entwurf eines plattenförmigen Photobioreaktors mit besonderem Hinblick auf die innenliegenden Verklebungen zum Abtrag ständiger und dynamischer Beanspruchungen. Vorausgehende Material‐ und Klebstoffuntersuchungen werden erläutert. Aufbauend auf den Erkenntnissen der experimentellen Untersuchungen realisierte das Forschungsteam einen Prototyp der Größe 3,00 × 1,35 m2 für einen Freiland‐Teststand zur Untersuchung der Langzeitstabilität. Der Beitrag schließt mit einem Ausblick auf die zukünftige Fassadenintegration.