bluuebunny/crossref_metadata_2025 huggingface dataset:
EVALUATION OF THE THERAPEUTIC AND PREVENTIVE POTENTIAL OF THE MEDICINAL PRODUCT CANEPHRON N IN THE TREATMENT OF GESTATIONAL PYELONEPHRITIS IN PREGNANT WOMEN
Authors: Sheremeta Roman , Sabadash Maksim , Shulyak Alexander
Published: November 2018

Background: Gestational pyelonephritis (GP) is one of the most common and serious diseases of the middle and second half of pregnancy, which complicates approximately 6 % of pregnancies, and is one of the leading causes of non-obstetric pre-delivery hospitalization.

Methods. The paper provides data from the open, multicentre, prospective, comparative (parallel group) study in 60 pregnant women diagnosed with gestational pyelonephritis, which were divided into two groups 30 subjects each. Patients in the treatment group received antibacterial therapy for 7 days + treatment with standard dosage of medicinal product Canephron N for 3 months. Patients in the control group received antibiotic therapy alone for 7 days.

Results. The average age of pregnant women at the time of diagnosing was 23±6.23 years; it was the first pregnancy for 39 women (65 %). The most common complaints at admission to the in-patient department were as follows: lumbar pain (96.2 %), dysuria (70.2 %), rise in temperature above 38°C (64.4 %). Leukocyturia and bacteriuria were detected in 100 % of cases with prevalence of E. coli in 84.2 % (101 of 120) of cases. By 30 day in GP patients in the treatment group bacteriuria was detected in 2/30 (6.67 %) patients, and in the control group – in 5/30 (16.7 %) patients (p 1: 2 <0.05), by 60 day in the treatment group – 2/30 (6.67 %), in the control group – 8/30 (26.7 %) (p 1: 2 <0.05), respectively, by 90 day – 3/30 (10 %) and 10 (33.3 %), respectively (p 1: 2 <0.05). The disease relapsed in 1 of 30 (3.33 %) GP patients in the treatment group and 3/30 (10 %) patients in the control group (p 1: 2 <0.05) and 3/30 (10 %) patients in the treatment group with CP, and 7/30 (23.3 %) patients in the control group during the follow-up period (p 1: 2 <0.05).

The use of the herbal medicinal product Canephron N in pregnant women with gestational pyelonephritis and in the acute exacerbations of chronic pyelonephritis has shown its high efficacy and undoubted therapeutic and prophylactic effect, good tolerability and decrease in the frequency of relapses of pyelonephritis.
COMPARISON OF QUALITY OF LIFE OF PATIENTS WITH LOCAL DISTRIBUTED BREAST CANCER FORMS AFTER CHEMOTHERAPY IN REGIONAL AND SYSTEM REGIMES
Authors: Dumanskiy Yuriy , Bondar Oleksandr , Tkachenko Oleksandr , Stoliachuk Evhenii , Ermakov Vasilii
Published: November 2018

For several decades, breast cancer (BC) undoubtedly ranks first in the structure of oncopathology and is the most common cause of the loss of working capacity of the female population in most countries. Considering the increasing quality of care for patients with breast cancer, there is the need for standardization and implementation of methods to assess not only quantitative but also qualitative component of a comprehensive opinion on the results of therapy. Therefore, an important indicator to be taken into account is the quality of life (QL) of a patient.

Definition of QL of patients with inoperable forms of locally advanced breast cancer before and after neoadjuvant courses of systemic polychemotherapy (SPCT) and selective intra-arterial polychemotherapy in combination with systemic (SIAPCT).

154 patients with LA BC T4A-DN0-3M0, who received comprehensive treatment on the basis of the Donetsk regional antitumor center and the University clinic of the Odessa National Medical University during the period from 2000 to 2017, who received SPCT or SIAPCT as a neoadjuvant course, were included in the study.

According to the quality of life during the treatment period, wavelike dynamics with a clear advantage of selective intra-arterial polychemotherapy over the system was observed. According to the quality of health between groups, the marginal statistically significant difference in favour of regional PCTs was formed.

In a detailed study of each of the options found stable symptomatic scale dependent components of the integral index of quality of life on the severity and duration of intoxication syndrome. On the basis of the results obtained, the statistical advantage of the RMRM remains with the regional PCT.

The QL study is a reliable, informative and economical method for assessing the health status of the patient, both at the group and at the individual level. In cancer studies, the evaluation of QL is an important criterion for assessing the effectiveness of treatment and has a prognostic value.
THE ROLE OF GROUP EDUCATIONAL PROGRAMS IN MODIFICATION OF THE CARDIOVASCULAR RISK MAIN FACTORS
Authors: Isayeva Anna , Rieznik Larysa , Vovchenko Marina , Buriakovska Olena
Published: November 2018

Aim – to study the influence of Healthy Schools "Healthy Lifestyle Basis" education on modifying of cardiovascular risk main factors.

Materials and methods. 57 patients with cardiovascular diseases were examined. General clinical examination, anthropometric examinations (body weight, height, body mass index, and body composition), blood pressure measurement, and cholesterol determination, as well as its fractions in blood, were carried out before and after training course. The educational cycle included 9 lessons.

Results. It was found that Healthy Schools education contributes to better both systolic and diastolic blood pressure monitoring. Thus, initially target blood pressure levels (<140/90 mmHg for patients without diabetes mellitus and <140/85 mmHg in case of diabetes) were observed in 49 % of patients, at the end of the training cycle – in 67 %. At the same time, the patients’ anthropometric parameters (BMI, fat and muscle tissue content, visceral fat) as well as cholesterol and its atherogenic serum fractions, did not change significantly. The patients’ education did not affect motivation level for their lifestyle improvement. So the number of patients consuming less than5 grams of table salt per day and over400 grams of vegetables and fruit did not change significantly. The level of physical activity between the examined patients did not change.

Conclusion. The training course “Healthy Schools: Healthy Lifestyle Basis" contributes to improvement of blood pressure level monitoring, but does not significantly affect behavioral risk factors and does not lead to improvement of lipid metabolism monitoring in patients with cardiovascular disease. It is necessary to search for new more effective preventive care models for patients with high cardiovascular risk.
DIAGNOSTIC VALUE PARAMETERS OF ACUTE PHASE REACTANCES OF INFECTIOUS-INFLAMMATORY PROCESS IN DIAGNOSTICS OF EARLY NEONATAL SEPSIS
Authors: Bezrukov Leonid , Koloskova Olena , Vlasova Olena
Published: November 2018

An advanced progress of clinical neonatology in recent years has enabled to achieve considerable success in newborn management with due respect to both medical treatment and general care, especially in the group of neonates with low body weight at birth. At the same time, neonatal sepsis in the early period still predetermine sickness and mortality of newborns.

Material and methods. Clinical-paraclinical indices with detection of diagnostic value of C-reactive protein and interleukins-6 and 8 were evaluated in 100 neonates with available susceptibility factors to early neonatal infection from mother’s side and clinical signs of organ dysfunction in neonates with precautions of generalized infectious-inflammatory process at the end of their first day of life.

Results. The data obtained substantiate that low concentrations of IL-6 and IL-8 prevail, and therefore the mentioned mediators hardly can be used to verify early neonatal infection. In the majority of children C-reactive protein elevated the concentration of 10.0 mg/L which is traditionally considered to be a discriminant as to the verification of an infectious process in newborns.

Conclusions. None of the clinical signs associated with infectious-inflammatory process in newborns in the first two days of their life enabled to verify reliably availability of systemic bacterial infection.
APPLICATION OF DIGITAL TOMOSYNTHESIS IN DIAGNOSING SPINAL TUBERCULOSIS – FIRST CLINICAL EXPERIENCE IN UKRAINE
Authors: Sharmazanova Olena , Deresh Nataliya , Urina Larisa , Kovalenko Yuriy
Published: November 2018

Diagnosis of tuberculous spondylitis is based on the comparison of clinical-laboratory, bacteriological data and radiological methods. Digital tomosynthesis is a new method of X-ray diagnostics for performing with high-resolution limited-angle tomography at short-pulsed exposures in one pass of the tube with reconstruction of several hundred longitudinal sections of the research object without superposition of tissues. Possibilities of tomosynthesis are studied for various clinical situations.

Aim of research. To study and apply the possibilities of digital tomosynthesis in the diagnosis of tuberculous spondylitis, conduct a comparative analysis with other radiological methods.

Materials and methods. Digital tomosynthesis was performed for 95 patients with various spine diseases (select group 8.4 % with tuberculous spondylitis) at the domestic digital roentgen-diagnostic complex with the mode of digital tomosynthesis after performing digital projectional radiography of spine.

Results and discussion. The benefits of tomosynthesis were shown and a comparative analysis with other visualization methods in the diagnosis of spondylitis was performed. Cases of the first clinical application of the method in Ukraine were demonstrated.

Conclusion. Digital tomosynthesis of the spine is a new promising diagnostic tool by which you can obtain qualitative spine images in the form of numerical thin sections with no exaggeration effect. Results are comparable to CT data for detecting bone destruction at lower radiation load levels. Digital tomosynthesis provides better visualization of the small joints of the spine and the ability to evaluate each anatomical element of the vertebra at different depths, helps to detect pulmonary manifestation of tuberculosis.
ESTIMATION OF THE EFFECT OF PLATELET RICH PLASMA PRODUCTS IN THE INTEGRATION OF POLYPROPYLENE MESH IMPLANT IN BIOLOGICAL TISSUES. EXPERIMENTAL MODEL IN RATS
Authors: Atanasov Dmitro
Published: November 2018

The aim of the research is to determine morphological changes in the area of implantation of the polypropylene mesh implant and to determine the effect on the integration of the prosthesis of locally introduced adipose tissue and platelet rich plasma.

Materials and methods. The experiment was performed on 36 sexually mature males of the Wistar line rats. The experiment simulated, studied and quantified local morphological responses and changes in developing in biological tissues that are in contact with implanted highly porous lightweight (80 g/m2) mesh implant in isolation and also in conditions of local administration of fatty graft and platelet rich plasma.

Results: Assuming introduction of adipose tissue and platelet rich plasma in the zone of integration of mesh alloprosthesis under the influence of introduced regenerative cytokines as well as stromal stem cells activated by them there is an earlier activation of regenerative processes, enhanced angiogenesis which determines the optimal nature of the integration of the prosthesis with the formation of thin collagen fibers in more early terms minimizing excess peri-prosthetic fibrosis. Isolated introduction into the implantation zone of fatty suspension determines similar changes that have a slightly less pronounced character. These changes are quantitatively studied and the results obtained are statistically significant.

Conclusions: Applying a fatty graft together with platelet rich plasma in the area of implantation of the lung polypropylene prosthesis, there was an accelerated tissue reaction from the integration of the prosthesis.

Mesenchymal stem cells of adipose tissue that is a target for plasma cytokines enriched with thrombocytes have a more pronounced effect in stimulating reparative processes provided that they are simultaneously administered with PRP compared with isolated administration without PRP. The use of platelet rich plasma and adipose tissue design has a significant positive effect on local angiogenesis. Under conditions of improved angiogenesis and other stimulating factors in the conditions of introduction of adipose tissue and PRP, the integration of the prosthesis occurs with significantly lower peri-prosthetic fibrosis.
INVESTIGATION OF THE CINNAMON INFLUENCE ON THE WHEAT BREAD QUALITY ENRICHED WITH FLAX SEEDS OIL MEAL
Authors: Bilyk Olena , Bondarenko Yulia , Hryshchenko Аnna , Drobot Vira , Kovbasa Volodymyr , Shutyuk Vitaliy
Published: November 2018

The materials of the article are studies that are conducted with the aim of expanding the use of non-traditional raw materials for functional purposes in the technology of bakery products. Research is conducted to determine the effect of spiciness cinnamon on the quality of semi-finished products and finished bakery products from wheat flour enriched with flax seeds oil meal.

To improve the quality of wheat bread, enriched with flax seeds oil meal, and expand the assortment of bakery products with health properties, the authors propose to use spice cinnamon in the formula of wheat bread in an amount of up to 2 % of the weight of flour. The taste and aroma of these products is characteristic of wheat bread with a pleasant cinnamon flavor. Dosage of cinnamon to 4 % of the flour mass also provides good consumer characteristics of products, however, more pronounced flavor and flavor of cinnamon can limit the circle of consumers of such products. The use of 6 % of cinnamon in the recipe of products leads to a significant deterioration in the volume of products and provides them with too intense flavor. Determination of the content of bisulphite-binding substances in the crumb and crust of products is confirmed by improvements in the fragrance of products with the addition of cinnamon.

It has been established that the cinnamon in dough leads to an increase in the elastic properties of gluten, and the more, the more it is added. Along with this, it is noted that cinnamon leads to a decrease in the fermentation intensity of the dough. This is probably due to the active antibacterial properties of cinnamon, which suppress the yeast fermentation activity. These factors and cause the deterioration of the volume of finished products in the case of dosing cinnamon in an amount of 4 % or more.

It has been proved that on the indicators of crumbling and deformation of the crumb, products with added cinnamon retain their freshness similarly to the control one. However, it is noted that the introduction of cinnamon reduces the amount of mold of microflora in products.
COMPARATIVE QUALITY ASSESSMENT OF PEANUT AND PEANUT-FLAXSEED OIL
Authors: Lenert Svitlana , Dubinina Antonina , Deynichenko Gregoriy , Khomenko Olga , Haponceva Oksana , Antonyuk Irina , Medvedieva Anzhelika , Demichkovska Miroslava , Vasylieva Olena
Published: November 2018

The aim of research is quality assessment of peanut and peanut-flaxseed oil for organoleptic and physico-chemical indicators, as well as the study of fatty acid composition of fat. It will determine the consumer properties of these products. Comparative studies of consumer properties of peanut and peanut-flaxseed oil for organoleptic indicators, fatty acid composition, acid and peroxide numbers are carried out. To determine the fatty acid composition of fat, the gas chromatography method is used. The measurement of the acidic and peroxide number of fat is performed by a titrimetric method.

The research results of organoleptic and physicochemical parameters, as well as the fatty acid composition of peanut oil and peanut-flaxseed blend have shown that the flavor qualities of the developed oil are balanced and high, therefore new oil can be consumed by consumers. The enrichment of peanut oil with flaxseed helps improve the fatty acid composition beyond the set of a significant increase in unsaturated fatty acids (linoleic by 23 %, oleic by 28 %, linolenic by 96 %). It has also been proved that the use of flaxseed oil does not have a significant effect on the acceleration of the hydrolytic processes of vegetable oil fats.

The expediency of mixing peanut and flaxseed oil is shown, which makes it possible to obtain new blended peanut-flaxseed oil, balanced by fatty acid composition.
INVESTIGATION OF THE WATER-RETAINING CAPACITY OF THE PROTEIN-HYDROCARBON COMPLEX OF RYE-WHEAT DOUGH WITH ADDITION OF POLYFUNCTIONAL FOOD SUPPLEMENT “MAGNETOFООD”
Authors: Tsykhanovska Iryna , Evlash Victoria , Alexandrov Alexandr , Lazareva Tetiana , Bryzytska Oksana
Published: November 2018

Under modern conditions, creation of new high effective technologies of bread is connected with a necessity of solving a problem of the products quality at the discrete work of enterprises: at processing raw materials (flour) with decreased properties in ecologically unfavorable regions, manufacturing products with prolonged storage terms, high consumption characteristics, diet destination, for treating-prophylactic nutrition. The development of innovative technologies of bakery products of rye-wheat flour is based on revelation of conceptual approaches, connected with creation of new functional technological properties of dough systems and ready products. That is why in bread technologies there are searched new raw material sources, food supplements-improvers, able to raise consumption characteristics, storage terms, food value; to enrich a ready product with functional ingredients and so on. The water-retaining capacity (WRC) – is one of main functional-technological parameters of food raw materials and ready products, because it favors the output, prime cost and quality characteristics of bakery products. For increasing WRC of rye-wheat dough, there is proposed the polyfunctional food supplement “Magnetofood”. For reasoning the mechanism of its interaction with polymer matrixes of lipo- and glucoproteids of rye-wheat flour and WRC mechanism of the food supplement “Magnetofood” in rye-wheat dough – there was investigated the influence of “Magnetofood” on processes of hydration, dissolution and water-retention of rye-wheat flour. It was established, that introduction of the food supplement “Magnetofood” in rye-wheat flour in amounts: 0,10; 0,15; 0,20 % of a flour mass increases its solubility and WRC: solubility – by 4,5 – 12,5 %; WRC – in 1,1 – 1,3 times, respectively. The rational dose of the food supplement “Magnetofood” is experimentally determined -– 0,15 % of a flour mass. There was investigated the influence of the food supplement “Magnetofood” on a quantity of bound water by experimental samples of rye-wheat flour at temperatures from 30 to 70 оС. It was established, that the temperature growth in experiments results in increasing the quantity of bound water for all experimental samples. Addition of “Magnetofood” in amounts: 0,10; 0,15; 0,20 % of a flour mass favors the increase of bound water in 1,2 – 1,5 times, comparing with the control (without “Magnetofood”). The received experimental data may be used at developing the technology of rye-wheat bread, enriched with the polyfunctional food supplement “Magnetofood”; and also at developing innovative technologies of food system systems (especially, meat, confectionary, milk ones). The results of the study may be used for developing recipes and technologies of food products for increasing their output, water-retaining and stabilizing capacities.
Shift-invert diagonalization of large many-body localizing spin chains
Authors: Pietracaprina Francesca , Macé Nicolas , Luitz David J. , Alet Fabien
Published: November 2018

We provide a pedagogical review on the calculation of highly excited
eigenstates of disordered interacting quantum systems which can undergo
a many-body localization (MBL) transition, using shift-invert exact
diagonalization. We also provide an example code at
https://bitbucket.org/dluitz/sinvert_mbl.
Through a detailed analysis of the simulational parameters of the random
field Heisenberg spin chain, we provide a practical guide on how to
perform efficient computations. We present data for mid-spectrum
eigenstates of spin chains of sizes up to L=26L=26.
This work is also geared towards readers with interest in efficiency of
parallel sparse linear algebra techniques that will find a challenging
application in the MBL problem.
Corporate social responsibility of financial sector institutions in the light of sustainable development goals financing: the role of banks and stock exchanges
Authors: Makarenko Inna , Yelnikova Yulia , Lasukova Anna , Rahman Barhaq Abdul
Published: November 2018

Significant gap in investment resources for financing Sustainable Development Goals can be overcome with the revitalization of the corporate social responsibility mechanism of the financial sector institutions, for example banks and stock exchanges as the largest players in the global financial sector. The most relevant for them are Goals 1, 5, 8, 10, 13, 17. Incorporating these goals into activities of the financial sector institutions requires not only the activation of their CSR mechanism in the directions indicated by the targets, but also the radical restructuring of all business processes and the reorientation of their overall sustainability strategy. Analysis of current sustainability reporting disclosure by financial sector institutions in global and regional aspects was conducted. Based on the analysis, the authors define the role of CSRs of banks and stock exchanges in SDG financing as follows: banks – ensuring their own sustainability and efficiency through CSR mechanisms, formation of new tools, methods and technologies of financial support of SDG; stock exchanges – minimization of information asymmetry in investor decision making, taking into consideration ESG criteria, formation of exemplary disclosure practices and new markets and market benchmarks by listing companies.
Dengue Fever: A Worldwide Threat An Overview of the Infection Process, Environmental Factors for a Global Outbreak, Diagnostic Platforms and Vaccine Developments
Authors: Hosseini Samira , Oliva-Ramírez Jacqueline , Vázquez-Villegas Patricia , Rodriguez-Garcia Aida , Muñoz-Soto Rodrigo B. , Aghamohammadi Nasrin , Martinez-Chapa Sergio O.
Published: November 2018

Current review article focuses on dengue, which is one of the most fatal infectious illnesses
and is considered to be a worldwide threat. The paper covers essential topics including an overview on
neglected tropical diseases with specific emphasis on Dengue fever, mosquito's cycle of life and mechanism
of infection, adaptive response, and different stages in dengue immunopathogenesis. The current
work is also dedicated to the thorough study of dengue outbreak across the globe with a narrowed study
to tropical and subtropical regions. Moreover, this review article demonstrates the correlation between
climate factors and dengue incidence. Furthermore, we present an overview of the detection strategies of
dengue including the latest developments in commercial and non-commercial platforms. Several attempts
in developing an effective vaccine to protect individuals from dengue infection and the stage of
clinical trials are gathered in the present work as well. Future directions including bio-control are also
discussed in this review article. In an overall view, effective management of Dengue is a multidisciplinary
task that requires international involvement from different backgrounds and expertise to address
this global concern. This review article briefly portrays some of these connecting areas across the disciplines
while many other perspectives remain uncovered.
Hydroalcoholic Extract of Cuscuta Epithymum Enhances Pentobarbitalinduced Sleep: Possible Involvement of GABAergic System
Authors: Forouzanfar Fatemeh , Vahedi Mohammad M. , Aghaei Azita , Rakhshandeh Hassan
Published: November 2018

Background:

Insomnia is the most common sleep disorder. The present study was undertaken to
evaluate the sedative-hypnotic potential of hydroalcoholic extract (HAE) of Cuscuta epithymum and its fractions.

Methods:

HAE and its fractions including: water fraction (WF), ethyl acetate fraction (EAF) and n-hexan
fraction (NHF) were i.p administered to male mice and 30 min later pentobarbital (30 mg/kg, i.p.) was injected
to induce sleep. Then the latent period and continuous sleeping time were recorded. Besides, 30
mins after administration of HAE motor coordination (rota-rod test) were assessed. Additionally, LD50 of
HAE was determined and the possible neurotoxicity of the extract was tested on neural PC12 cells.

Results:

The HAE and NHF decreased the latency of sleep and significantly increased the duration of
sleep induced by pentobarbital. These effects of C. epithymum were reversed by flumazenil. HAE did not
affect the animals’ performance on the rotarod test. The LD50 value for HAE was found to be 4.8 g/kg.
HAE and its fractions had no toxicity effect on the viability of PC12-cell line.

Conclusion:

The results of the present study indicate that the HAE and NHF have significant sedativehypnotic
effects in mice without major toxic effect and that the benzodiazepine receptors are involved in
the sedative-hypnotic effects of this plant.
Synthesis of (R)-2-benzylmorpholine employing catalytic stereospecific rearrangement of L-Phenylalaninol
Authors: Reddy Mandapati Bhargava , Anandhan Ramasamy
Published: November 2018

An efficient synthesis of (R)-2-benzylmorpholine has been accomplished starting from
L-phenylalaninol by employing stereospecific rearrangement of β-amino alcohol using catalytic
amount of (CF3CO)2O as a key step.
Investigating the Relationship the Severity of Coronary Artery Disease with Serum Levels of Vitamin D in Men after Eliminating the Effect of Diet
Authors: Birgani Farshad K. , Shahi Majid M. , Cheraghian Bahman , Haybar Habib
Published: November 2018

Background:

Coronary artery disease (CAD) is one of the most common cardiovascular diseases that can lead to mortality, inability, and lower productivity levels.

Objective:

The aim of this study was to determine the relationship between serum vitamin D level and cardiovascular risk factors and the severity of CAD after determining and eliminating the confounding effects of dietary patterns in male patients undergoing angiography.

Methods:

This descriptive-analytic study was carried out on 132 men undergoing angiography during 2017 and 2018. To this end, food frequency questionnaire (FFQ) and physical activity questionnaire (PAQ) were completed for the patients. Fasting blood sugar (FBS), triglyceride, total cholesterol, HDL-C, LDL-C and vitamin D levels were also investigated.

Results:

Serum vitamin D levels significantly decreased with an increase in CAD severity (p=0.001). Also, low serum levels led to the highest severity of CAD (p=0.005). However, there was no significant difference between patients with vitamin D deficiency with different degrees of CAD (p=0.084). Also, the highest percentage of individuals with normal serum levels of vitamin D was observed in the group without any blocked blood arteries (normal) (p=0.023).

Conclusion:

This study shows an inverse relationship between serum 25(OH) D level and the severity of CAD. Our data show that vitamin D plays an important role in preventing CAD. These findings could help design prospective studies and clinical trials on a wider scale to investigate the effects of vitamin D interventions in preventing the development of CAD.
Clinical Research on the Aortic Elasticity in Patients with Type 1 Diabetes Mellitus Complicated with Hypertension
Authors: Wang Zheng , Wan Yulei
Published: November 2018

Background:

To investigate the characteristics of aortic elasticity in type 1 diabetes mellitus
(DM1) patients with hypertension using dual-source computed tomography (DSCT).

Methods:

Subjects were divided into four groups: 31 with hypertension (EH group), 28 with DM1
(DM1 group), 30 with hypertension and DM1 (DM1 + EH group), and 30 healthy volunteers (control
group, CG). ECG-gated DSCT was used to measure the cross-sectional area of the aorta in diastole
and systole and calculate the aortic elasticity (D). Analysis of variance and multiple linear regression
were used for statistical analysis.

Results:

Compared with the CG, aortic elasticity (D) in the DM1 group patients was not significantly
decreased. Compared with the EH group, the DM1 + EH group showed no significant change.
The aortic elasticity (D) in the EH and DM1 + EH groups was significantly lower than that in the
CG and DM1 group.

Conclusion:

DM1 slightly affects the aortic elasticity of the descending aorta, whereas hypertension
exerts the main effect.
Design, Synthesis and In Vitro Evaluation of Novel Anti-HIV 3-Pyrazol-3- yl-Pyridin-2-One Analogs
Authors: Kumar Sanjay , Gupta Shiv , Gaikwad Shraddha , Abadi Leila F. , Bhutani Late K. K. , Kulkarni Smita , Singh Inder P.
Published: November 2018

Background:

Natural products have shown potent anti-HIV activity, but some of these
also possess toxicity. The pharmacophoric fragments of these natural products have scope of combination
with other pharmacophoric fragment and derivatization to reduce toxicity and increase the
potency. Combination of natural product fragments from different classes of anti–HIV compounds
may lead to a new class of potent anti–HIV agents.

Objective:

Design, in silico prediction of drug-likeness, ADMET properties and synthesis of pyrazol–
pyridones. Evaluation of the anti–HIV–1 activity of synthesized pyrazol–pyridones.

Methods:

Pyrazol–pyridones were designed by combining reported anti–HIV pharmacophoric
fragments. Designed molecules were synthesized after in silico prediction of drug-likeness and
ADMET properties. Compounds were evaluated for activity against HIV–1VB59 and HIV–1UG070.

Results:

QED value of designed pyrazol–pyridones was greater than the known drug zidovudine.
The designed compounds were predicted to be noncarcinogenic and nonmutagenic in nature. Seventeen
novel pyrazol–pyridones were synthesized with good yield. Compound 6q and 6l showed
activity with IC50 values 6.14 µM and 15.34 µM against HIV–1VB59 and 16.21 µM and 18.21 µM
against HIV–1UG070, respectively.

Conclusion:

Compound 6q was found to be most potent among the synthesized compounds with a
therapeutic index of 54.31against HIV–1VB59. This is the first report of anti–HIV–1 activity of
pyrazol–pyridone class of compounds. Although the anti–HIV–1 activity of these compounds is
moderate, this study opens up a new class for exploration of chemical space for anti–HIV–1 activity.
Application of an LC-MS/MS Method to a Urinary Excretion Study of Triflusal and its Main Metabolite 2-hydroxy-4-trifluoromethyl Benzoic Acid in Human Urine
Authors: Ge Jie , Wang Jin-Wen , Guo Qi-Yan , Wen Ai-Dong
Published: November 2018

Objective:

A validated liquid chromatography-tandem mass spectrometry method (LCMS/
MS) was established to simultaneously determine the concentration of triflusal and its main
metabolite 2-hydroxy-4-trifluoromethyl benzoic acid(HTB) in human urine.

Methods:

The separation was performed on a Dikma C18 column using isocratic elution with
acetonitrile-4 mmol/L ammonium acetate aqueous solution containing 0.3 % formic acid water (78: 28,
V/V). The method involved extraction with methanol using protein precipitation. The precursor-toproduct
ion transitions with multiple reaction monitoring was m/z 247.1→161.1, 204.8→106.7and
136.9→93.0 for triflusal, HTB and salicylic acid(IS), respectively. The method showed good linear
relationships over the ranges of 0.08 to 48 μg/mL and0.5 to 50 μg/mL.

Results:

It was the first time that a urinary excretion study of triflusal capsule as oral. The cumulative
urinary recovery showed 8.5% and 2.7% for triflusal and HTB, respectively.

Conclusion:

This method was successfully used for evaluating the pharmacokinetic properties of triflusal
and HTB in urine in Chinese healthy subjects.
A Systematic Review of Analytical Profiles of SGLT2 Inhibitors and their Combinations for Treatment of Type 2 Diabetes Mellitus
Authors: Thakor Niyatee Savaikar , Amrutkar Sunil Vishvanath
Published: November 2018

The frequency of Type 2 Diabetes Mellitus worldwide is rising rapidly and is estimated to reach 4.4% of the world’s population or about 366 million people by 2030. In the view of National Diabetes Statistics report 2017, 30.3 million people have diabetes in the United States (9.4%) of total population, out of which, 23.1 million are diagnosed and 7.2 million (23.8%) people with Diabetes are undiagnosed. One of the recently introduced therapeutic classes is Sodium Glucose co- Transporter 2 (SGLT2) Inhibitors. Since 2010 USFDA has approved 6 single dose and 7 fixed dose combinations for treatment of Type 2 Diabetes Mellitus. SGLT2 Inhibitors such as Canagliflozin, Dapagliflozin and Empagliflozin are in combinations with most of the dosage forms. This article reviews published analytical methods reported so far in the literature to find SGLT2 inhibitors. They include various techniques like spectrophotometry, high-performance liquid chromatography, liquid chromatography-electrospray ionization-tandem mass spectrometry and high-performance thin layer chromatography for their routine, impurity profiling and stability indicating determination in different pharmaceutical matrices.
Cardiotoxicity Associated with Midazolam in a Patient with Diphtheria
Authors: Gohil Jayendra R. , Jindal Sonal
Published: November 2018

Background:

Adverse cardiorespiratory events are associated with midazolam continuous IV infusion, used for sedation.

History:

Here we are reporting a case of 5 year old male child suffering from diphtheria induced
airway obstruction, and myocarditis, who received midazolam in the form of IV infusion for sedation
while undergoing mechanical ventilation for respiratory failure.

Adverse Event:

Six hours after starting midazolam infusion he started developing pulsus bigeminus
and bradycardia and eventual death after two hours.

Conclusion:

Midazolam, although considered one of the safest drugs, need to be used cautiously in a
child with myocarditis, because of the possible cardiotoxic effect in an already affected heart.
Transplantation of Adipose-derived Cells for Periodontal Regeneration: A Systematic Review
Authors: Dziedzic Dilcele Silva Moreira , Mogharbel Bassam Felipe , Ferreira Priscila Elias , Irioda Ana Carolina , de Carvalho Katherine Athayde Teixeira
Published: November 2018

This systematic review evaluated the transplantation of cells derived from adipose tissue for applications in dentistry. SCOPUS, PUBMED and LILACS databases were searched for in vitro studies and pre-clinical animal model studies using the keywords “ADIPOSE”, “CELLS”, and “PERIODONTAL”, with the Boolean operator “AND”. A total of 160 titles and abstracts were identified, and 29 publications met the inclusion criteria, 14 in vitro and 15 in vivo studies. In vitro studies demonstrated that adipose- derived cells stimulate neovascularization, have osteogenic and odontogenic potential; besides adhesion, proliferation and differentiation on probable cell carriers. Preclinical studies described improvement of bone and periodontal healing with the association of adipose-derived cells and the carrier materials tested: Platelet Rich Plasma, Fibrin, Collagen and Synthetic polymer. There is evidence from the current in vitro and in vivo data indicating that adipose-derived cells may contribute to bone and periodontal regeneration. The small quantity of studies and the large variation on study designs, from animal models, cell sources and defect morphology, did not favor a meta-analysis. Additional studies need to be conducted to investigate the regeneration variability and the mechanisms of cell participation in the processes. An overview of animal models, cell sources, and scaffolds, as well as new perspectives are provided for future bone and periodontal regeneration study designs.
Synthesis and Evaluation of 3-(1,3-dioxoisoindolin-2-yl)-N-substituted Phenyl Benzamide Analogues as HIV Integrase Strand Transfer Inhibitors
Authors: Wadhwa Pankaj , Jain Priti , Patel Arpit , Shinde Shantanu , Jadhav Hemant R.
Published: November 2018

Background: A series of novel 3-(1,3-dioxoisoindolin-2-yl)-N-substituted phenyl benzamide
derivatives was synthesized and tested in vitro against human immunodeficiency virus
type-1 Integrase (HIV-1 IN).

Methods:

Out of the 18 analogues, six (compounds 16c, 16h, 16i, 16m, 16n and 16r) showed significant
inhibition of strand transfer by HIV-1 integrase. For these six compounds. IC50 was below
5.0 µM. In silico docking studies revealed that the presence of 2-phenyl isoindoline-1,3-dione motif
was essential as it was found to interact with active site magnesium.

Results:

To further confirm the results, cell-based HIV-1 and HIV-2 inhibitory assay was carried out.

Conclusion:

These compounds possess structural features not seen in previously reported HIV-1
integrase inhibitors and thus can help further optimization of anti-HIV-1 integrase activity.
Sonic Stimulation and Low Power Microwave Radiation Can Modulate Bacterial Virulence Towards Caenorhabditis elegans
Authors: Patel Priya , Patel Hiteshi , Vekariya Dhara , Joshi Chinmayi , Patel Pooja , Muskal Steven , Kothari Vijay
Published: November 2018

Background: In view of the global threat of antimicrobial resistance, novel alternative approaches to deal with infectious bacteria are warranted, in addition to the conventional invasive therapeutic approaches.

Objective:

This study aimed at investigating whether exposure to sonic stimulation or microwave radiation can affect virulence of pathogenic bacteria toward the model nematode host Caenorhabditis elegans.

Methods:

Caenorhabditis elegans worms infected with different pathogenic bacteria were subjected to sonic treatment to investigate whether such sound treatment can exert any therapeutic effect on the infected worms. Virulence of microwave exposed bacteria was also assessed using this nematode host.

Results:

Sound corresponding to 400 Hz, and the divine sound ‘Om’ conferred protective effect on C. elegans in face of bacterial infection, particularly that caused by Serratia marcescens or Staphylococcus aureus. The observed effect seemed to occur due to influence of sound on bacteria, and not on the worm. Additionally, effect of microwave exposure on bacterial virulence was also investigated, wherein microwave exposure could reduce virulence of S. aureus towards C. elegans.

Conclusion:

Sonic stimulation/ microwave exposure was demonstrated to be capable of modulating bacterial virulence.
Safety of Pharmaceutical Excipients and Regulatory Issues
Authors: Ramesh Kanteti V.R.N.S. , Yadav Hemant , Sarheed Omar
Published: November 2018

Background:

Pharmaceutical excipients are critical in the formulation of any dosage form. Not many additives employed in the drug product manufacture have properties, which meet the desired qualities that the finished product must have. Therefore, it is mandatory to mix the drug substance with other substances to overcome the deficiencies. As a result, almost all pharmaceutical products are mixtures of active pharmaceutical ingredient and additives. So, there is a compelling need of these substances and normally they occupy the major part of any drug product. Excipients are of different chemical categories that have varying physicochemical properties like solubility, miscibility and the nature and source of these materials vary. With growing number of pharmaceutical excipients and polymers, the question of evaluating their toxicity is becoming a complex issue. Many polymers and novel excipients are now available in the market and with their diverse chemical nature and different sources and presence of impurities and their adverse effects will further complicate the safety profiling of these excipients.

Conclusion:

This review article will discuss the unwanted biological activities of some commonly used excipients and issues of the supply of the pharmaceutical excipients that need to be highly regulated and monitored to ensure availability of quality and pure excipient compounds.
Assessment of Heavy Metals Contamination in Drinking Water of Garmian Region, Iraq
Authors: Issa Hayder Mohammed , Alshatteri Azad
Published: November 2018

Drinking water of safe quality is a critical issue for human survival and health. Water pollution by heavy metals is very crucial because of their toxicity. This study assesses potential of heavy metals pollution in drinking water in Garmian Region, East Iraq. Water samples were investigated for 23 heavy metals and 6 chemical contaminants collected from 16 locations. The analysis was performed by using coupled plasma optical emission spectroscopy (ICPOES, Spectro Arcos). High levels of Al, Se, Sr, and Fe have been detected at certain locations in study area. Statistical analysis techniques of the correlation matrix (CM), and cluster hierarchical analysis (CA) were conducted. The heavy metals pollution index (HPI), heavy metals evaluation index (HEI), and contamination Index (Cd) were used applied. These indices linked with the statistical analysis to interpret relationships among the tested parameters in water samples and to investigate the pollution sources over the study region. Even with the significant correlations between the HPI, Cd, and HEI, they showed dissimilar impact of examined heavy metals on the water quality. The most reliable pollution evaluation index of HEI for drinking water showed that 44% of the water samples is critically polluted. Sources of the contamination are most likely coming from natural geological sources. Anthropogenic impact was only noticed at several sites in the study area.
Perlindungan Data Pribadi dan Privasi Penumpang Maskapai Penerbangan pada Era Big Data
Authors: Nugraha Ridha Aditya
Published: November 2018

AbstractThis article examines issues surrounding airline passenger data protection in the realms of big data  phenomenon. The history of privacy, including two landmark cases, shall be elaborated from the beginning to provide a comprehensive discussion. How the airlines operate through utilizing personal data, also their compliance towards the enacted law shall be analyzed. Then the sentiments towards Passenger Name Record Agreement which speaks on behalf of flight security is also being explored. Finally, the article aims to provide some recommendations towards the current drafting of the new Indonesian Data Protection Act draft by taking into account lessons learned from airlines.IntisariThis article examines issues surrounding airline passenger data protection in the realms of big data  phenomenon. The history of privacy, including two landmark cases, shall be elaborated from the  beginning to provide a comprehensive discussion. How the airlines operate through utilizing personal data, also their compliance towards the enacted law shall be analyzed. Then the sentiments towards Passenger Name Record Agreement which speaks on behalf of flight security is also being explored. Finally, the article aims to provide some recommendations towards the current drafting of the new Indonesian Data Protection Act draft by taking into account lessons learned from airlines.
Analisis Putusan Mahkamah Konstitusi Nomor 100/PUU-XI/2013 tentang Pembatalan Frasa 4 Pilar Kehidupan Berbangsa dan Bernegara
Authors: Hastangka Hastangka , Armawi Armaidy , Kaelan Kaelan
Published: November 2018

AbstractThe term Four Pillar became a public debate. The main problem is the use of the Four Pillars term consisting of Pancasila, the 1945 Constitution, NKRI, and Bhinneka Tunggal Ika has raised questions from the community. This research is a qualitative research that examines the existing norms and legislation through the normative laws approach. The purpose of this research is to analyze the normative laws and the impact of the Constitutional Court’s decision on the use of the Four Pillars term. The Constitutional Court’s decision is in accordance with the logic of legal language and the prevailing rules related to the concept and the nature of Pancasila, the 1945 Constitution, the Unitary State of the Republic of Indonesia, and Unity in Diversity can not be categorized into one of the same variants is true. In this case the MPR RI has made a mistake in the language logic using the term 4 Pilar MPR RI. IntisariIstilah Empat Pilar menjadi perdebatan publik. Pokok persoalannya yaitu penggunaan istilah Empat Pilar yang terdiri atas Pancasila, UUD 1945, NKRI, dan Bhinneka Tunggal Ika telah menimbulkan pertanyaan dari masyarakat. Penelitian ini merupakan penelitian kualitatif yang mengkaji norma dan peraturan perundang-undangan yang ada melalui pendekatan penelitian hukum normatif. Tujuan penelitian ini adalah menganalisis dasar normatif dampak putusan MK terhadap penggunaan istilah Empat Pilar. Putusan MK telah sesuai dengan kaidah logika bahasa hukum dan kaidah yang berlaku terkait dengan konsep dan hakikat Pancasila, UUD 1945, NKRI, dan Bhinneka Tunggal Ika tidak dapat dikategorikan menjadi satu varian yang sama. Dalam hal ini MPR RI telah melakukan kesalahan logika bahasa dalam menggunakan istilah 4 Pilar MPR RI.
ABOUT THE FREE-VIBRATION MODE SHAPES OF ELASTOPLASTIC DISSIPATIVE SYSTEMS
Authors: Potapov Alexander N.
Published: November 2018

The author presents the conditions of the generalized orthogonality of the free-vibration mode shapes of an elastic dissipative system, for which traditional classical orthogonality conditions are a private case. As opposed to these conditions, the above ratios contain the mass matrix, the damping matrix, and the diagonal form of the spectral characteristics (damping coefficients and mode-shape frequencies). Within the theory of time analysis, free-vibration mode shapes of an elastoplastic system are built on the basis of using a schematized diagram of strain with hardening. The author proposes a design scheme that reduces the process of nonlinear vibrations to a sequence of processes flowing according to a linear scenario within the time intervals called quasilinear. In these intervals, the parameters of the dynamic model (elements of the stiffness matrix and the damping matrix) remain unchanged, all the changes occur only when passing through the critical points. As a result, the author formulated the condition for the nondegenerate state of an elastoplastic dissipative system. According to the condition, local plastic zones characterized by the size, the number and location of the zones on the design scheme of the structure correspond to each quasilinear interval. Since within the intervals, the parameters of the plastic zones are unchanged, the conditions of the generalized orthogonality of the mode shapes of the elastoplastic system are satisfied by analogy with the vibration mode shapes of an elastic dissipative system. The free-vibration motion of a hinged beam with three degrees of freedom are analyzed taking into account local plastic zones with different lengths and the location of zones in different nodes. It is shown that the configuration of the forms of elastoplastic oscillations differs qualitatively from the configuration of the corresponding forms of elastic vibrations.
COMPUTER MODELLING OF THE STRESS-STRAIN STATE OF PLUG-IN CONNECTIONS OF REINFORCED CONCRETE COLUMNS WITH THE COVERAGE PLATES UNDER THE OUT-OF-SQUARE ECCENTRIC COMPRESSION
Authors: Sokolov Boris S. , Troshkov Evgeniy O.
Published: November 2018

he technique and results of computer simulation of the stress-strain state of plug joints of reinforced concrete columns with overlap plates under the effect of out-of-square eccentric compression are described. An analysis of the results obtained is provided to optimize the experimental research plan and to develop a technique for calculating the strength of the joints used in the UICSS bearing system.