bluuebunny/crossref_metadata_2025 huggingface dataset:
IANAL. However ...
Authors: McNaughton Neil
Published: November 2024

Oil IT Journal editor Neil McNaughton is not a lawyer. But he observes that much of a corporation’s key intellectual property resides in ‘legal’. Should we allow the large language models to access our contracts? What broader ‘conclusions’ can an LLM draw from ‘secret’ company stuff?
Cybersecurity Challenges in the Hashemite Kingdom of Jordan
Authors: Muhaisen Heba Al , Aldabbas Dr. Ali , Alqaisi Dr. Abeer , Almomani Sayel , Alzeit Dr. Rehan Abu
Published: November 2024

In an era marked by rapid advancements in technology and the digital revolution, cyber-security has become one of the most significant technical issues across countries, including nation-states like the Hashemite Kingdom of Jordan. This paper examines the very complex cyber security issues that Jordan experiences and evaluates how the legal structure established in Cyber Security Act No. 16 of 2019 can be used to face these challenges? Comparatively analyzed with global standards, the research identifies substantial shortcomings in Jordan’s cybersecurity enforcement, coordination and integration capabilities. The research also discusses how international cooperation and public awareness can help improve national cybersecurity. The study appears to indicate that while significant steps have been taken Jordan’s legal infrastructure, there is a need for continued modernization in line with a rapidly evolving cyber threat landscape. Finally, the paper ends by suggesting policy interventions that can bolster cybersecurity in Jordan, and it also draws attention to a number of issues regarding risk-based approaches for managing cyber threats regulation across different regulatory authorities; as well the necessity of more inclusive digital public engagement efforts. This is necessary to safeguard our vital structures in Jordan and provide a stable, secure cyberspace.
Exploring the Juvenile Justice Act: Legal Framework and Psychosocial Interventions for Children in Conflict with the Law
Authors: Deepa. D Christiana Venita , Jacob SJ Dr. M.S. Joseph Antony , Manalan S Thamarai
Published: November 2024

Understanding and supporting children in conflict with the law (CCL) is vital for their positive transformation. By exploring the factors influencing their behaviour, developmental influences, historical context of juvenile justice and effective interventions, we empower these youths for a brighter future. CCL refers to individuals under 18 alleged or found to have committed an offense. Recognizing their needs and challenges is essential for devising suitable rehabilitation strategies. Identifying risk factors contributing to children's criminal involvement is essential for effective intervention. These factors range from individual and family aspects to wider community and societal influences. Targeting these factors can prevent CCL. Embracing a developmental perspective is crucial for understanding the reasons behind a child's unlawful actions. Positive parenting, quality education, healthy peer interactions and community support play pivotal role in shaping a child's choices. Exploring the history of juvenile justice offers insights into societal responses to young offenders. A shift from punitive measures to rehabilitation reflects an evolving understanding of CCL's unique needs. Understanding definitions from the Juvenile Justice Act is vital for effective work with CCL. Concepts like "best interest of the child" and "observation home" guide interventions and decisions. Implementing psychosocial interventions addressing cognitive, emotional, and social needs proactively rehabilitates CCL. Disciplinary measures, counselling, vocational training, mentorship, and access to education with a positive approach are the key. Integrating these aspects creates a holistic framework to support CCL. This approach fosters personal growth, safer communities, and a just society.
The Influence of Spiritual Well-being on the Quality of Life of Cancer patients in Palliative care, Chennai.
Authors: Smilee Leuca , Kirubakaran H. , Jacob Dr. Joseph Antony
Published: November 2024

Cancer has become a big threat to India as it has been estimated to have a mortality rate of 0.3 million deaths per day, also there have been recorded 80.6000 existing cases of Cancer patients by the end of the last century. This study is about the influences of spirituality on the quality of life of cancer patients in palliative care. The study was conducted in RMD palliative care and Jeevodaya hospice. All the institutions work with cancer patients who are in their end stage. The researcher used semi- semi-structured interview schedule consisting of Two scales formulated by the European Organization for Research and Treatment of Cancer. The scales were EORTC QLQ- C30 and EORTC QLQ-SWB32. The collected data is analyzed using SPSS software. Pearson’s correlation is done to find the relation between spiritual well-being and the Quality of Life of patients. It is found that spiritual well-being has a weak influence on the quality of life. In the Indian context, the patients relate spirituality only to their religious faith and hope. They don’t realize how to find meaning in their lives. All the questions answered were about religion, faith, and belief. They live without undergoing much pain, therefore they think their quality of life is good. According to them, pain determines their quality of life. Enhancing their bodily symptoms will not result in a good quality of life. Quality of life is achieved through holistic care. They measure their quality of life in the context of physical well-being and spirituality in the context of religion, due to which the perceived spirituality is different from the actual spirituality.
Hidden Diagnosis - Chronic Non-Healing Leg Ulcer
Authors: Pritam Jeyaraman Sai , Saranya C. , Kannan R.
Published: November 2024

Chronic ulcers present a significant clinical challenge, often necessitating tailored, multi-faceted interventions and strict adherence to treatment protocols. Accurate diagnosis and management require a thorough understanding of the ulcer's etiology and associated systemic conditions. This case report highlights a 35-year-old male with a chronic non-healing leg ulcer, compounded by a history of deep vein thrombosis (DVT) and pulmonary thromboembolism. Despite negative findings for common vasculitic and procoagulant profiles, a biopsy revealed leukocytoclastic vasculitis, and subsequent HLA-B51 testing confirmed the diagnosis of Behçet’s disease. The patient was treated with a combination of prednisolone, mycophenolate mofetil, and rivaroxaban, resulting in notable regression of the ulcer. This case underscores the importance of considering Behçet’s disease in young male patients presenting with chronic non-healing ulcers and thromboembolic events. Early diagnosis and vigilant, multidisciplinary management are essential to mitigate complications such as pulmonary artery hemorrhage and neuro-Behçet’s disease. This report emphasizes the need for comprehensive diagnostic approaches and long-term follow-up to prevent irreversible organ damage and improve patient outcomes.
Mixed Connective Tissue Disease Presenting as Diabetic Ulcer in a 52 Year Old Female Patient: A Case Report
Authors: Pritam Jeyaraman Sai , Saranya C. , Kannan R.
Published: November 2024

Mixed connective tissue disease (MCTD) is a rare and complex autoimmune condition characterized by overlapping features of systemic lupus erythematosus (SLE), systemic sclerosis, polymyositis/dermatomyositis, and rheumatoid arthritis. Due to the varied clinical presentation and the absence of validated classification criteria, early diagnosis can be challenging, often leading to misclassification or delayed recognition. Here, we report a case of a 52-year-old female with MCTD and vasculitis, underscoring the importance of considering uncommon autoimmune etiologies in patients with non-healing ulcers. The patient presented with skin tightening, Raynaud’s phenomenon, and chronic non-healing ulcers, initially attributed to diabetic complications. Diagnostic evaluation revealed high-titre anti-U1-RNP antibodies, confirming MCTD. Treatment with oral steroids, cyclophosphamide, and sildenafil led to significant clinical improvement, particularly in ulcer resolution. This case emphasizes the critical need for early intervention and a multidisciplinary approach in managing autoimmune vasculitis associated with MCTD to prevent progression and optimize patient outcomes.
Comparing the Effect of Topical Lignocaine and Bupivacaine in Nasal Packs for Pain Relief in Post Operative Nasal Surgery Patients
Authors: Raghu Dr. Varsha , Shree N Dr. Raadhika , Kakka Dr. Nishit
Published: November 2024

This randomized controlled trial compared the analgesic efficacy of lignocaine, bupivacaine, and placebo nasal packs in patients undergoing nasal surgeries, including septoplasty and functional endoscopic sinus surgery (FESS). A total of 100 patients, aged 18–60 years, were randomly assigned into three groups: lignocaine (n=34), bupivacaine (n=33), and placebo (n=33). Postoperative pain was assessed using the Visual Analog Scale (VAS) over 24 hours. Additional analgesic requirements, side effects, recovery time, and length of hospital stay were recorded. Bupivacaine provided significantly lower pain scores at all intervals compared to lignocaine and placebo (p < 0.05). The bupivacaine group had a lower need for additional analgesics (39.4%) compared to lignocaine (76.5%) and placebo (81.8%) (p = 0.041). Side effects such as nausea and vomiting were similar across all groups. The bupivacaine group experienced a shorter hospital stay (2.0 days) compared to the lignocaine (2.5 days) and placebo (3.0 days) groups (p = 0.038). In conclusion, bupivacaine-soaked nasal packs offer superior pain relief, reduce the need for additional analgesics, and shorten hospital stays, making it a preferable option for postoperative pain management in nasal surgeries.
Evaluation of Advanced Diagnostic Methods for Typhoid Fever in the Malwa Region, Punjab
Authors: Bector Rajan , Kumar Dr. Naresh
Published: November 2024

Aim: The aim of study was to assess the effectiveness of conventional and advanced diagnostic techniques to overcome on false positive result of typhoid cases due to cross reactivity of different antibody present in human body. Method: Sampling was conducted in selected hospitals at both primary and secondary levels in the Malwa region. Blood and stool samples were collected from patients suspected for typhoid fever, and tests were performed at Bector Diagnostics Lab. The laboratory parameter like IgG and IgM Typhi Dot done form the blood and direct Stool culture at selective media recommended by CLSI guideline. A total of 450 patients were included in the study, out of which 150 patients taken as healthy controls and 300 were the patients showing symptoms of typhoid and had a fever for four days. Result: The results for “sensitivity and specificity” of all 3 diagnostic tests were as follows: 47.61% and 40.14% for Widal testing in hospitals, 100% and 96.90% for TyphiDot, and 79.16% and 99% for Stool culture. The Widal test showed interoperator variability and was insensitive. Overall, the IgM antibody-detection device TyphiDot showed the most encouraging and dependable results. Conclusion: This study demonstrated the importance of TyphiDot in the apparent treatment of typhoid fever. Its diagnosis is necessary for effective treatment or preventative measures. More diagnoses are required to ensure accuracy in typhoid fever cases.
Impact of High-Fidelity Simulation on the Confidence Level of Pediatric Residents to Manage Pediatric Emergencies
Authors: Louai Boudour , Alloush Rasha , Alameleh Hadeel , Alwahab Alaa Abd , Farzat Bachir Abdul Jawad , Chaudhary Adeel
Published: November 2024

Background: Children having seriously ill health conditions pose new challenges to healthcare professionals in pediatric emergencies. The training based on simulation is a promising procedure for equipping junior professionals with the required potential. Objectives: Studying the impact of High-Fidelity Simulation (HFS) on the confidence levels of pediatric residents for taking care of patients having complications that are critical and also considering emergency procedures. Methodology: A quasi-experimental design utilized having surveys done before and after training to evaluate confidence levels. The research was executed in October 2023. The evaluation model of Kirkpatrick was supposed to evaluate the training program impact. After that, data was collected and entered into MS Excel and then analyzed on SPSS. Results: The research executed two sorts of surveys, including a pre-course survey and a post-course survey. Out of 40 residents, only 30 gave responses with a 75% rate. Descriptive analysis revealed varying levels of confidence across different domains of pediatric care. However, statistical analysis revealed no significant changes in confidence levels post-training in certain areas. These findings suggest that while the training program may have positively influenced confidence in some domains, further investigation is needed to determine its comprehensive impact on the confidence of residents. Conclusion: Our study emphasizes the effectiveness of HFS in enhancing the confidence of pediatric residents in managing critically ill patients and emergency procedures. While statistical significance was not achieved across all domains, the overall trend indicates a positive impact on residents' perceptions of their abilities in pediatric emergency care. Research in the future should revolve around more strategies augmenting the confidence of the residents in the care of pediatric emergencies.
Empirical Study on the Impact of Service Quality Dimensions on Satisfaction of Students: With Reference to Executive Coaching’s of Kota
Authors: Sharma Heemika , Pareek Dr. Renu
Published: November 2024

Purpose: The purpose of this study is to see how the service quality elements affect student satisfaction in private coaching institutes of Kota District. This research unifies, refines, and extends the empirical work undertaken in the field of education service quality in the coaching institutes of Kota, in addition to acknowledging the critical roles of service quality in boosting student satisfaction. It has a number of implications for managers at these coaching institutes, including the importance of strategies related to increasing service quality which will effect the satisfaction level of students. Objective: As one of the first attempts to explore empirically the impact of the service quality approach on student satisfaction this research adds to academic and practical knowledge. The study aims to investigate the relationship between service quality and student satisfaction of private coaching institutes. It also aims to study the Impact of Service Quality on Student Satisfaction of private coaching institutes. The overall study aims to identify the service quality factors leading to student satisfaction. Methodology: The study is based on Empirical research The independent variables in the study are the factors of service quality like Tangibility, reliability, responsiveness, empathy and assurance, while the dependent variable taken for the study is student satisfaction. A quantitative method is used to analyse the data collected through structured questionnaires which was administered in five coaching institutes in Kota: Allen Career Institute, Resonance, Bansal Classes, Aakash, and Vibrant Academy. Data was collected from 400 respondents (384 According to Morgan formulae and 16 as contingency respondents). Stratified simple random sampling method was used to collect the reliable data. The Data was analysed using Statistical tools like correlation and regression analysis. Results: The results shows that all the independent variables are highly correlated with the dependent variable which shows that each element of service quality has an impact on the satisfaction level of the students enrolled in the private coaching institutes of Kota. The Regression analysis concludes that there is a positive impact of tangibility, reliability and assurance on students’ satisfaction and there is a negative impact of responsiveness and empathy on the satisfaction of students of the private coaching institutes. Further, the study gives important guidance for future research opportunities, such as investigating the impact of the marketing mix approach on other coaching institutes' performance criteria.
Chemical Profiling of Kalangkala (Litsea angulata) Seed Using LC-HRMS as Antioxidants
Authors: Mahfudh Nurkhasanah , Ilmia Nisrien , Nisa Khoirun , Mustofa Ahda  , Warsi Warsi , Suryani Ade Irma
Published: November 2024

Kalangkala (Litsea angulata) is one of the most frequent florae utilized in traditional medicine in the Kalimantan area, and this showed significant antioxidant activity on the part of the seeds. Ability antioxidants it has seed sometimes become potency development material natural as material standard medicine, so need did its identification compounds present in seeds sometimes. Research purposes: this is to identify compound potential antioxidants as candidate materials for active pharmacy. The method used is to test the activity of antioxidants using the DPPH technique from the n-hexane, ethyl acetate, and methanol kalangkala seed fractions, achieved by identifying components using LC-HRMS. Research results show that the IC50 values from the n-hexane, ethyl acetate, and methanol kalangkala seed fraction are, respectively, 52.05, 46.10, and 32.84 ppm. Identification results compound from methanol fraction with activity antioxidant best show 5 major compounds with abundant more than 3% are 3-[(2E)-3,7-Dimethyl-2,6-octadien-1-yl]-4-hydroxy-5-methoxybenzoic acid, 2-[(2E)-3,7-Dimethyl-2,6-octadien-1-yl]-5-hydroxy-6-methoxy-3-methyl-1,4-benzoquinone, Betaine, Choline, and (4E,6E)-4,6-Tetradecadiene-8,10,12-triyn-1-yl acetate.
Effectiveness of Fenestration and Discectomy among Patients Presenting with Lumbar Disc Herniation
Authors: Tahir Muhammad , Hassan Naseer , Hassan Raza , Naqvi Syed Abdul Basit , Subzwari Muznah , Mehmood Asif
Published: November 2024

Background:Research-StackExchange47, BackgroundLumbar disc herniation (LDH) is a frequent cause of back pain and neurological dysfunction that often requires surgical treatment. There writing was another popular technique fenestration the other favorite disceyotomy, to relieve symptoms by decompressing ✓ spinal nerve roots. The study is an investigation of these existing methods and their comparison with the aim of evaluating efficacy in symptom relief as well as patient outcome. Objective: aim to compare the clinical outcomes of fenestration and discectomy in lumbar disc herniation. Study design : Descriptive case series comparative study. Place and duration of study. 6th September 2023 to 6the March, 2024 at the Department of Neurosurgery, Qazi Hussain Ahmad Medical Complex Nowshera. Methods: The patients were included in this descriptive case series study that was conducted from 6th September 2023 to 6the March, 2024 at the Department of Neurosurgery, Qazi Hussain Ahmad Medical Complex Nowshera. A sample size was determined at 46% success rate with the help of WHO software, a confidence interval of 95% and margin of error was set at 9%. Assessment of the outcomes in patients including pain and functional improvement were calculated using p-values between groups by standard deviation. Results: This retrospective study included 118 patients (34 females and 84 males) with lumbar disc herniation. Overall, the proportion of males to females was 2.47:1 In a total of 88 patients (74.58%), efficacy was reported, and the mean score for effective relief from symptoms was 3.5 ± 1.2 (SD). Statistical analysis revealed significant differences between the techniques (p < 0.05) with fenestration being marginally superior. Conclusion: Fenestration and discectomy for lumbar disc herniation: a follow-up study. As for symptomatic relief, fenestration seemed to be slightly better. Conclusions. This study provides evidence for both surgical methods as valid surgical options; however, choice of technique should be individualized based on patient characteristics. It is recommended that future studies with larger samples, to provide for more inclusive results.
Pyrazole Amides Towards Trailblazing Antimicrobial Research: Bridging in Vivo Insights and Molecular Docking Studies
Authors: Mangala Khandekar , Aasiya Choudhary , Naikwadi Varsha , Gaikwad Vikram , Jadhav Tanaji , Bhikshapathi DVRN , Palled Mahesh , Karadi Aravind , Kulkarni Ravindra
Published: November 2024

Antimicrobial resistance presents a significant threat to contemporary healthcare systems, making it increasingly difficult to treat infections that were once easily managed. This study aims to assess the efficacy of pyrazole benzamide derivatives (M5a–M5o), which were synthesized for their antimicrobial and antifungal activities. These compounds were tested against methicillin resistant staphylococcus aureus (MRSA), vancomycin resistant staphylococcus aureus (VRSA), mycobacterium tuberculosis H37Rv and other resistant species. The minimum inhibitory concentrations (MIC) were determined using standardized protocols to evaluate their potency and effectiveness. Molecular docking studies were also conducted to explore potential interactions and binding affinities at the molecular level, providing further insights into their antimicrobial and anti-tubercular mechanisms. Compounds M5i, M5k, and M5b emerged as the most potent, displaying MIC value of 3.12 μg/ml. These compounds show great potential as new agents in addressing the growing problem of antimicrobial resistance. Molecular docking studies against Enoyl-[acyl-carrier-protein] reductase (4DRE), revealed key interactions, with compound M5n showing a docking energy of -9.8 kcal/mol and compound M5g at -9.6 kcal/mol. These compounds formed important hydrogen bonds and π-interactions with residues like Lys165, Gly14, Ser94, and Ile21. Overall, the findings indicate that specific pyrazole-benzamide derivatives exhibit promising antimicrobial and antifungal activities, underscoring their potential as therapeutic agents. Additionally, the integration of molecular docking studies proves valuable in guiding the development and optimization of these compounds for future therapeutic applications.
Analysis of Stylistic Aspects of the Appearance of Ellipsis in Speech
Authors: Nasretdinova Mukhlisa Nizometdinovna , Saydikramova Umida Xamidullaevna , Saydikramova  , Fuzaylova Nargiza Abdusamatovna , Fayziyeva Adiba Khusnutdinovna , Jabborova Zuhra Tursinaliyevna
Published: November 2024

In this article, an attempt was made to trace the history of learning elliptical sentences in Uzbek and English, to distinguish the most common structural and semantic types, and to study the comparative analysis of these types of sentences in these languages. If we take into account the current state of the study of elliptical sentences, we should note that there is no generally accepted definition of elliptical sentences, the lack of clarity of the characteristic features of these sentences, and the absence of a unified approach to the typology of elliptical sentences. Despite the fact that a sufficient number of works have been devoted to elliptic sentences, currently the problem of ellipsis can be classified as understudied, and the prospects for studying this issue are wide and in demand.
Characterization of Nano Calcium Carbonate Extracted from Eggshells
Authors: Assi Sajjad Arif , Shawkat Sadeq Muneer
Published: November 2024

Organic waste, especially eggshells, represents a valuable resource for the synthesis of calcium carbonate nanoparticles, which have significant industrial and medical applications. This study describes the methodology for converting eggshells into calcium carbonate nanoparticles through heat treatment and nano milling processes. Advanced characterization techniques, including TEM, SEM, and AFM, were used to analyze the morphology and structure of the synthesized nanoparticles. The particles were found to be of nanometer dimensions, with a size of around 150 nm and a distinctive spherical shape, as shown in the TEM images. SEM images showed that the surface of calcium carbonate nanoparticles synthesized from eggshells is smooth, crystalline, and spherical or nearly spherical. FTIR analysis revealed the presence of distinct functional groups for calcium carbonate, with peaks at 713–868 cm⁻¹, consistent with previous studies. The results show that nanoparticles manufactured from calcium carbonate possess unique properties that enhance their applicability in various fields, and promote sustainability and environmental preservation.
Knowledge Regarding Lactation Diet Among Caregivers of Postnatal Mothers in a View to Develop Information Booklet
Authors: Thorat Paurnima Sanjay , Ray Dr. Supriya Pottal
Published: November 2024

Background: The role of primary caregiver is crucial in providing care to primigravida mothers in improving health by supporting breastfeeding. According to UNICEF poor nutrition taken by lactating mother is more affecting on infants as well as mothers health. Caregivers are most responsible for provision of postnatal care at hospital and at home too as they used their previous experiences during taking care of postnatal mothers. Food taboos during lactation are stronger than the pregnancy period. According to ministry of family and health welfare it is important to fill the gap between knowledge and practices. The aim of this study is to assess the knowledge and self-reported cultural practices regarding diet during lactation among caregivers with a view of developing information booklet. Methodology: Quantitative research approach is been adopted wherein the non-experimental exploratory research design was used for this study. Approval was taken from IEC, BV (DU) CON, Pune. Non-probability purposive sampling technique was used to collect data from caregivers which was validated from the experts and reliability, pilot study was done to conduct the study. The study was conducted on 200 caregivers of primipara postnatal mothers from selected hospitals of Pune city. The collected data was analyzed using descriptive and inferential statistics. Result: Majority (73%) findings of the caregivers have average knowledge regarding diet during lactation and also it showed significant association between age, religion, relationship with postnatal mother and dietary pattern of postnatal mother. Conclusion: To conclude this study on basis of above findings, the aim of this study is achieved. Hence researcher has developed information booklet to update complete knowledge regarding diet during lactation also myths were discussed with the help of evidences.
In Silico Efficacy of Oleic Acid, n-Hexanoic acid, and Epiglobulol Obtained from Conocarpus Lancifolius against Class D β-lactamases
Authors: Sobia Farrukh , Qurashi Shahazad Niwazi , Ali Nasir A. , Abdalhalim Amal Ramadan , Khattab Ashraf Abdelmageid Ibrahim , Sharma Pragya , Khan Shagufta
Published: November 2024

Introduction: Antimicrobial resistance poses an escalating global challenge, compounded by the sluggish pace of new antibiotic discovery. Objectives: This study undertook an in silico analysis of phytochemicals derived from Conocarpus lancifolius, a local plant in the Jazan region of Saudi Arabia, to investigate potential antibacterial agents. Methods: The 3D crystallographic structure of OXA-48 was sourced from the RCSB protein databank (PDBID: 3HBR) and pre-processed. The Lib Dock algorithm facilitated the analysis of optimal binding orientations and potential interactions between compounds and the 3HBR. Results: The docking analysis outcome revealed Oleic acid as the most active compound and the binding mode exhibited that the -OH group of the terminal carboxylic acid moiety formed hydrogen bonds with Thr197 and Ala207, and the oxygen atom showed bonding with Lys116. Moreover, N-hexanoic acid also demonstrated promising binding interactions with the 3HBR, displaying hydrogen bond interactions with Lys208, Tyr211, and Ser70, along with hydrophobic alkyl interactions with Lys208 and Met115 at the protein's active sites. Unfavourable donor-donor and acceptor-acceptor bindings were also observed with Ser70 and Arg250 residues. Conclusions: The OXA-48 and NDM-1 predominate in countries of the Arabian Peninsula. Our findings suggest oleic acid as a promising candidate for combating OXA-48 β-lactamase, pending further assessment of its atomic structure via X-ray crystallography.
Neutrophil-Lymphocyte Ratio as Predictor of Prognosis In Patient with Heart Failure with Reduced Ejection Fraction that Treated With Angiotensin Converting Enzyme Inhibitor or Angiotensin Receptor Neprilysin Inhibitor: A Prospective Cohort Study in Aceh,
Authors: Novia Rizki , Heriansyah Teuku , Riswan Muhammad , Munirwan Haris , Muqsith Muhammad
Published: November 2024

Introduction: Heart failure (HF) and inflammation are related. Angiotensin Converting Enzyme Inhibitors (ACE-I) and Angiotensin Receptor Neprilysin Inhibitors (ARNI) can reduce inflammation by lowering neutrophil counts. The neutrophil-lymphocyte ratio (NLR) is a simple marker of inflammation. There is a lack of studies showing that NLR can predict prognosis in patients with HFrEF, and further investigation is needed.Objectives: Investigating whether NLR could be a prognostic indicator for mortality and rehospitalization in patients with heart failure and reduced ejection fraction receiving treatment with ACE-I or ARNI.Methods: A prospective observational cohort study with double-blind methods was conducted at Zainal Abidin General Hospital, Banda Aceh, Indonesia. Two groups, ACE-I and ARNI, each comprised 40 participants. Initially, blood sampling was performed to determine NLR. Participants were observed weekly for three months for prognosis outcomes (death and rehospitalization). After three months, the remaining participants were invited for re-evaluation of the NLR.Results: This study found that pre-treatment NLR had a hazard ratio (HR) of 1.454 (95% CI: 1.266-1.670, p < 0.001). The risk ratio of abnormal pre-treatment NLR for rehospitalization was 6.56 in the ACE-I group and 8.33 in the ARNI group. Nevertheless, both ACE-I (p = 0.014) and ARNI (p = 0.032) decreased NLR levels.Conclusions: High NLR could be as a predictor of prognosis in patients with heart failure with a decrease in left ventricular ejection fraction that treated with ACE-I or ARNI, also ACE-I and ARNI could reduce NLR levels.
University Governance in the Legal Entrepreneurship of Intellectual Capital Around the Implementation of the SDGs
Authors: Velásquez Leticia María González , Vázquez Francisco Rubén Sandoval , Lirios Cruz García , Campas Celia Yaneth Quiroz , Córdoba Víctor Hugo Meriño , Ruíz Gilberto Bermúdez , Crespo Julio E. , González María del Rosario Molina , Esquer Lidia Amalia Zallas , Morales Francisco Espinoza , Ornelas Rosa María Rincón , Balderas Wilfrido Isidro Aldana , Fuentes José Alfonso Aguilar , Soto María Luisa Quintero , Sanhueza-Olave Miguel
Published: November 2024

Aim. The study's objective is to compare a theoretical model of university governance in the COVID-19 era. Since the literature consulted warns of the pandemic's impact on university governance, the factor structure was confirmed. Method. An exploratory, cross-sectional, and correlational study was carried out with a sample of 180 administrators, teachers, and students from a university in central Mexico selected for their participation in the social service system and professional practices in community health institutions. The instrument was evaluated using the Delphi technique in three phases: qualifying, comparative, and reiterative- reconsidered. The University Governance Scale was applied via Zoom session. The data were captured in Excel and processed in JASP. Reliability, validity, adjustment, and residual coefficients were estimated to contrast hypotheses. Results. The three-factor structure was corroborated: identity, reputation, and image. Although the first factor explained the highest percentage of variance, only 12 of 18 indicators correlated with its factors. Conclusions. The study's contribution lies in contrasting the university governance model in a scenario of exposure to COVID-19. Still, the study's limit lies in the non-generalization of the results to the university community.
Formulation and Evaluation of the Antimicrobial Potential and Embryotoxicity of Betanin-Zinc Nanoparticles
Authors: Varadarajan Nithya , Balan Mahalakshmi , Solaimuthu Hariprasath , Saji Joyal , Annes Theboral , Punniyakotti Saranya , Sambasivam Gopinath , R Afraahsulthana
Published: November 2024

Introduction: This study explores the green synthesis of betanin-based ZnO nanoparticles, with emphasis on their characterization, antimicrobial potential, and toxicity evaluation. Materials and methods: Zinc oxide nanoparticles (ZnO NPs) were produced using betanin isolated from Beta vulgaris, zinc hexahydrate, and 0.5M NaOH. To verify their structural and morphological characteristics, the produced betanin zinc oxide nanoparticles (BT-ZnO NPs) were examined using Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), and X-Ray Diffraction (XRD). Staphylococcus aureus, Streptococcus mutans, Enterococcus faecalis, and Candida albicans were among the bacterial strains against which the antibacterial activity of these green-synthesised BT-ZnO NPs was assessed. Concurrently, zebrafish (Danio rerio) embryos were subjected to different amounts (10, 50, and 100 µg/mL) in order to perform embryotoxicity experiments. Results: SEM analysis showed that BT-ZnO NPs are irregularly shaped with a tendency to aggregate, which may enhance surface area. FTIR confirmed functional groups like phenols and amines, aiding nanoparticle stability. XRD indicated a composition of 52.5% crystalline and 47.5% amorphous content, supporting structural stability and bioactivity. Anti-microbial potential of BT-ZnO NPs shows notable inhibition at higher concentrations. In contrast, Candida albicans exhibited resistance to the nanoparticles. Embryotoxicity results showed that the ZnO NPs caused decreased survival rates, hatching delays, and morphological abnormalities in the zebrafish embryos, such as tail malformations and yolk sac oedema in the 100 µg/mL treatment group. Conclusion: While this study demonstrates the efficacy of BT-ZnO NPs as strong antimicrobial agents, it also emphasizes the need for caution regarding their environmental and health impacts, particularly at higher concentrations.
Development and Validation of Sensitivity for Needs of Elderly Scale Among Caregivers Based on Maslow’s Theory
Authors: Torphaiboon Punyarat , Bhanthumnavin Duangduen L. , Bhanthumnavin Duchduen E. , Meekun Kosol , Renliang Li , Sakdapat Naksit
Published: November 2024

The world currently lives in an aging society. Demand for elderly caregivers and services is rapidly rising. Elderly care encompasses not only medical care, but also the art of human care. Love and respect are usually considered the backbone of the modality of caregivers. This study aimed at developing a sensitivity for needs of elderly scale (SNES) among caregivers. Maslow’s theory of hierarchical needs, especially stage 3 (love and belongingness needs) and stage 4 (esteem needs), was used as a conceptual framework. This study consisted of four steps. The sample groups for the first two steps of item quality and exploratory factory analysis were 420 nursing students. A three-factor model emerged, which includes the sensitivity of needs for love and empathy, the sensitivity of needs for respect, and the sensitivity of needs for honor and dignity. The newly constructed measure consisted of 10 items, which explained the variance by 52.18%. The third step of confirmatory factor analysis, using a new group of 384 nursing students, indicated the model fit. In the final step, the scale was validated using 171 elderly caregivers. Moderate to strong absolute magnitudes of correlations between the new scale and psycho-moral strength, core self-evaluation, future orientation and self-control, moral disengagement, and caring behavior were found. Incremental validity was tested. Discussion and recommendations for further research and implications of the newly constructed measure were offered.
Preventing Falls as a Part of Risk Management in Israeli Geriatric Centers: A Systematic Review
Authors: Dakka Dr. Falah Jamal , Itzhakov Adina , Ras Mohamad Abo , Ganem Mohamad
Published: November 2024

Falls are a noteworthy concern in geriatric centers, regularly driving to extreme wounds, decreased quality of life, and expanded healthcare costs. This efficient survey points to look at the viability of different drop avoidance techniques actualized in Israeli geriatric centers as portion of chance administration. The survey incorporates an examination of numerous ponders centering on natural alterations, staff preparing programs, utilize of assistive gadgets, and patient-centered intercessions. Comes about show that a comprehensive approach combining these procedures is most viable in lessening the frequency of falls among elderly inhabitants. The discoveries emphasize the significance of nonstop observing, staff instruction, and individualized care plans to upgrade the security and well-being of geriatric patients. This survey highlights the basic part of drop anticipation in hazard administration and recommends headings for future investigate and approach advancement.
An in Vitro Assessment of the Retentive Property of Orthodontic Molar Bands Cemented With HY Agent-Containing Glass Ionomer Cement
Authors: Kumar Arshya , T.R. Prasanna Aravind
Published: November 2024

Introduction: In orthodontic treatments, glass ionomer cements (GICs) are the most extensively used adhesive materials. Through an acid-base reaction with enamel and dentin, they function as chelating agents, creating a chemical bond with stainless steel bands. It has been reported that glass ionomer cement (GIC) containing HY agents along with a complex of zinc fluoride, strontium fluoride, and tannic acid offers enhanced retentive strength. This combination contributes to reduced solubility, promotes remineralization, and improves acid resistance. In this in vitro study, Shofu HY Bond glass ionomer cement (HY GIC) was utilized to compare and evaluate the retentive strength of molar bands cemented with it against Voco Meron (VM GIC), a conventional glass ionomer cement.Materials and Methods: The long axis of fifty extracted maxillary first molars was aligned at 90 degrees to the acrylic resin blocks. Of these teeth, twenty-five were bonded using HY-GIC (group 1), while the remaining twenty-five were bonded with Meron GIC (group 2). The retentive properties of both types of glass ionomer cement were evaluated using universal testing equipment. An independent t-test was employed to compare the retentive strength between the two groups.Results: The average retentive strength of bands bonded with HY-GIC was measured at 14.65 ± 1.37 MPa, while bands using Meron GIC had a strength of 10.75 ± 1.10 MPa. The difference between these two values was statistically significant.Conclusion: There was a significant difference in the retentive strength between the 2 groups with Shofu HY bond GIC being superior.
Treatment Stability and Intermolar Width Changes in Patients Undergoing Surgically Aided Rapid Palatal Expansion: A Systematic Review
Authors: Kumar Arshya , T.R Prasanna Aravind
Published: November 2024

Introduction: The primary objectives of this systematic review were to critically evaluate clinical research assessing the stability of treatment outcomes following surgically aided rapid palatal expansion (SARPE) and to review published studies on intermolar width measurements taken before and after the treatment.Materials and Methods: A complete search across the electronic databases of the Cochrane Library, Google Scholar, PUBMED, Europe PMC and Science Direct, and a complimentary manual search of all orthodontic journals until 2024 were carried out. Selection criteria were used in the evaluation of the articles.Selection Criteria: Based on the PICOS (population, intervention, comparison, outcome, study design), the inclusion criteria were established. Adult patients with constricted maxillary arches and resulting transverse discrepancies were included in the study, and SARPE was carried out to address this clinical problem. Although many studies have been conducted on this topic, only randomized clinical trials were covered in this review. Excluded from this review were case reports, conference papers, animal experiments, in vitro research, case series, and FEM studies.Data Collection and Analysis: The primary outcome of the systematic review was the assessment of treatment stability and intermolar width changes in patients who underwent surgically aided rapid palatal expansion (SARPE). The selection of studies and data collection were conducted using standard methodological techniques. The assessment of the risk of bias was conducted, and the results were synthesized. Cochrane Risk of Bias was used for evaluating the outcomes obtained in the various studies. They were assessed by the GRADE protocol for Outcome Assessment for listing the parameters studied.Results: No significant difference in stability was noted between the two groups.Conclusion: With adequate literature review and outcome assessment, it can be concluded from this review that weak evidence exists to conclusively prove the stability of SARPE in the inter-molar and inter-first premolar regions. Immediate post-surgical stability is dependent on a variety of factors that have not been standardized in the various RCTs. Further well-designed trials that establish the extent of transverse discrepancies along with defining the obtained results with clarity are required before we obtain sufficiently conclusive outcomes.
Pain and Fertility Outcomes in Patients Undergoing Cyst Excision Versus Cyst Aspiration in Moderate to Severe Endometriosis: A Case Series
Authors: Shivaprakash Dr. Sreeja , Geetha Dr. K , Mannepalli Dr. Tanuja , Sindhuja Dr. R
Published: November 2024

Background: Endometriosis and ovarian cysts are prevalent gynecological disorders characterized by the presence of abnormal tissue growth in the pelvic cavity. Objective: To document the pain and fertility outcomes in patients undergoing cyst excision versus cyst aspiration in moderate to severe endometriosis presenting to a tertiary healthcare facility. Methods: This was a case series conducted in the Department of Obstetrics and Gynecology, Vinayaka Missions Medical College & Hospital, Vinayaka Missions Research Foundation (VMRF, Deemed to be University), Karaikal, Puducherry, India between June 2021 and May 2023 (n=14). Results: The study included 14 patients, divided evenly with 7 undergoing cyst excision and 7 undergoing cyst aspiration. Before surgery, both groups had comparable baseline characteristics in terms of age, symptom severity, and the nature of the ovarian cysts. After surgery, patients who underwent cyst excision showed a higher rate of pain relief compared to those who underwent cyst aspiration (61% versus 26%, respectively). In terms of fertility outcomes, 55% of patients in the cyst excision group achieved improved clinical pregnancy outcomes after surgery, whereas 35% of those in the cyst aspiration group had comparable results. Conclusion: Cyst excision appears to be associated with superior pain relief and faster recovery compared to cyst aspiration in patients with endometriosis or ovarian cysts.
Strategies for Strengthening Network Capacity in the Implementation of Food Security Policies at the Local Level in Indonesia
Authors: Seftiyana Yana , Susanti Gita , Alwi
Published: November 2024

This study aims to analyze network management strategies in the interactive governance perspective in the implementation of food security policies in North Luwu Regency, Indonesia. The complexity of food security issues requires effective collaboration and interaction among various actors in the policy network. Using a qualitative approach with an explanatory case study design, this research examines seven indicators of network management strategies: network (de-)activating, constitutional reform, (de)coupling games, changing incentives, changing internal structure and position of actors, changing relations, and management by chaos. Data were collected through in-depth interviews, participatory observation, and document analysis, involving relevant stakeholders from government agencies, farmer organizations, and private sector partners. The findings reveal that the application of network management strategies facilitates interaction among network actors and contributes to the success of interactive governance in implementing food security policies. Network (de-)activating involves the engagement of new coalitions and resource mobilization to strengthen cooperation and interaction. Constitutional reform through changes in rules and resources helps develop coordination mechanisms and strengthen policy integration. (De) coupling games demonstrate the separation of strategies carried out by various actors to support a holistic approach in achieving food security. Changing incentives through incentive interventions can increase motivation and active participation of actors in realizing food security. Changing relations indicate changes in cooperative relationships and actor roles to enhance effective collaboration. Management by chaos through the application of principles of flexibility, adaptability, and the ability to manage uncertainty can strengthen interactive governance in facing complex and dynamic challenges. This study recommends strengthening cross-sectoral collaboration, developing a structured incentive system, enhancing the capacity of farmer organizations, and optimizing the use of information technology to improve the success of interactive governance in food security policy implementation.
Attitudes and Perceptions of Leadership on Succession Planning in the Indian Manufacturing Sector
Authors: Sharma Jitendra , Patil Dr. Rajeshwari
Published: November 2024

This study explores the critical role of organisational leadership in the implementation of succession planning within Indian manufacturing organisations, given the increasing importance of seamless leadership transitions for maintaining operational stability and organisational resilience. The research investigates the attitudes and perceptions of senior leaders towards succession planning, focusing on how their views influence the execution of these strategies. Employing a mixed-methods approach with quantitative and qualitative interviews, the study gathers insights from a representative sample of organisational leaders. The main objectives are assessing leadership attitudes towards succession planning and understanding their perceptions of its implementation. Two key hypotheses are proposed: H01 asserts that leadership attitudes have no significant impact on succession planning, while H02 posits that leadership perceptions do not significantly influence its execution. Analysis of the collected data aims to reveal the extent to which leadership perspectives shape succession planning practices, providing valuable insights and recommendations for strengthening leadership approaches and succession frameworks. The findings are expected to contribute to a broader understanding of how effective leadership can foster a strong succession planning system, driving sustainable growth and resilience in the manufacturing sector.