bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure 2 from Gender-Specific Molecular and Clinical Features Underlie Malignant Pleural Mesothelioma
Authors: De Rienzo Assunta , Archer Michael A. , Yeap Beow Y. , Dao Nhien , Sciaranghella Daniele , Sideris Antonios C. , Zheng Yifan , Holman Alexander G. , Wang Yaoyu E. , Dal Cin Paola S. , Fletcher Jonathan A. , Rubio Renee , Croft Larry , Quackenbush John , Sugarbaker Peter E. , Munir Kiara J. , Battilana Jesse R. , Gustafson Corinne E. , Chirieac Lucian R. , Ching Soo Meng , Wong James , Tay Liang Chung , Rudd Stephen , Hercus Robert , Sugarbaker David J. , Richards William G. , Bueno Raphael
Published: April 2023

Schematic representation of the SNVs and/or chromosomal aberrations identified in BAP1, NF2, TP53, MYH9, RHOA, MYH6, MYH10, PIK3C2A, TNFRSF1A, and 22q and 9p in a panel of 147 MPM tumors.
Supplementary Figure 1 and 2 from Modulation of EZH2 Expression by MEK-ERK or PI3K-AKT Signaling in Lung Cancer Is Dictated by Different KRAS Oncogene Mutations
Authors: Riquelme Erick , Behrens Carmen , Lin Heather Y. , Simon George , Papadimitrakopoulou Vassiliki , Izzo Julie , Moran Cesar , Kalhor Neda , Lee J. Jack , Minna John D. , Wistuba Ignacio I.
Published: April 2023

EZH2 and MEK-ERK and PI3K/AKT signaling pathway expression in lung adenocarcinoma and HBEC cell lines KRAS wild-type and with different amino acid substitutions in codon 12 KRAS mutants and Sensitivity in vitro to AZD6244 and MK2206 was significantly increased in the presence of highly selective EZH2 inhibitor GSK343, EPZ6438 and GSK126 in NSCLC cells expressing mutant KRASG12C and KRASG12D, respectively
Supplementary Figure 1 from Gender-Specific Molecular and Clinical Features Underlie Malignant Pleural Mesothelioma
Authors: De Rienzo Assunta , Archer Michael A. , Yeap Beow Y. , Dao Nhien , Sciaranghella Daniele , Sideris Antonios C. , Zheng Yifan , Holman Alexander G. , Wang Yaoyu E. , Dal Cin Paola S. , Fletcher Jonathan A. , Rubio Renee , Croft Larry , Quackenbush John , Sugarbaker Peter E. , Munir Kiara J. , Battilana Jesse R. , Gustafson Corinne E. , Chirieac Lucian R. , Ching Soo Meng , Wong James , Tay Liang Chung , Rudd Stephen , Hercus Robert , Sugarbaker David J. , Richards William G. , Bueno Raphael
Published: April 2023

Expression levels of candidate genes in 151 patients by gender and histology
Supplementary Figure S4 from Oxygen-Enhanced MRI Accurately Identifies, Quantifies, and Maps Tumor Hypoxia in Preclinical Cancer Models
Authors: O'Connor James P.B. , Boult Jessica K.R. , Jamin Yann , Babur Muhammad , Finegan Katherine G. , Williams Kaye J. , Little Ross A. , Jackson Alan , Parker Geoff J.M. , Reynolds Andrew R. , Waterton John C. , Robinson Simon P.
Published: April 2023

MRI relationship to Hoechst 33342 and H&E
Supplemental Figures and Table 1 from Integrated Genomic Analysis of Pancreatic Ductal Adenocarcinomas Reveals Genomic Rearrangement Events as Significant Drivers of Disease
Authors: Murphy Stephen J. , Hart Steven N. , Halling Geoffrey C. , Johnson Sarah H. , Smadbeck James B. , Drucker Travis , Lima Joema Felipe , Rohakhtar Fariborz Rakhshan , Harris Faye R. , Kosari Farhad , Subramanian Subbaya , Petersen Gloria M. , Wiltshire Timothy D. , Kipp Benjamin R. , Truty Mark J. , McWilliams Robert R. , Couch Fergus J. , Vasmatzis George
Published: April 2023

Supplemental Table 1 and Figures 1-5 combined in single PDF file. Supplemental Table 1: Mate Pair sequencing data statistics. Supplemental Figure 1: KRAS Mutations in PDAC tumors. Supplemental Figure 2: Frequency copy number plots at the SMAD4 locus (A), chromosome 18 (B), FHIT (C), ZNF521 (D) loci in the primary PDAC tumors and for SMAD4, FHIT and ZNF521 in the PDX tumors (E). Supplemental Figure 3: Expression level changes of commonly hit genes. Supplemental Figure 4: TGFbeta responsive genes. Supplemental Figure 5: FHIT pathway genes and signaling networks.
Supplementary Figure 3 from Inhibition of MUC1-C Suppresses MYC Expression and Attenuates Malignant Growth in KRAS Mutant Lung Adenocarcinomas
Authors: Bouillez Audrey , Rajabi Hasan , Pitroda Sean , Jin Caining , Alam Maroof , Kharbanda Akriti , Tagde Ashujit , Wong Kwok-Kin , Kufe Donald
Published: April 2023

Rescue of A549/CRISPR cells with enforced MUC1-C expression.
Supplementary Figure Legends from Lack of p53 Augments Antitumor Functions in Cytolytic T Cells
Authors: Banerjee Anirban , Thyagarajan Krishnamurthy , Chatterjee Shilpak , Chakraborty Paramita , Kesarwani Pravin , Soloshchenko Myroslawa , Al-Hommrani Mazen , Andrijauskaite Kristina , Moxley Kelly , Janakiraman Harinarayanan , Scheffel Matthew J. , Helke Kristi , Armenson Kent , Palanisamy Viswanathan , Rubinstein Mark P. , Mayer Elizabeth-Garrett , Cole David J. , Paulos Chrystal M. , Voelkel-Johnson Christina , Nishimura Michael I. , Mehrotra Shikhar
Published: April 2023

Details for comparative characterization of the phenotype, and anti-tumor function of p53-KO vs Wt T cells is included.
Supplementary Figure S5 from miR-1298 Inhibits Mutant KRAS-Driven Tumor Growth by Repressing FAK and LAMB3
Authors: Zhou Ying , Dang Jason , Chang Kung-Yen , Yau Edwin , Aza-Blanc Pedro , Moscat Jorge , Rana Tariq M.
Published: April 2023

miR-1298-TRAP Crosslinking by UVA Treatment.
Supplementary Table S1 from PR55α Subunit of Protein Phosphatase 2A Supports the Tumorigenic and Metastatic Potential of Pancreatic Cancer Cells by Sustaining Hyperactive Oncogenic Signaling
Authors: Hein Ashley L. , Seshacharyulu Parthasarathy , Rachagani Satyanarayana , Sheinin Yuri M. , Ouellette Michel M. , Ponnusamy Moorthy P. , Mumby Marc C. , Batra Surinder K. , Yan Ying
Published: April 2023

Clinical characteristics of the PDAC specimens used for the study of PR55Î± expression by IHC
Supplementary Figure S2 from PR55α Subunit of Protein Phosphatase 2A Supports the Tumorigenic and Metastatic Potential of Pancreatic Cancer Cells by Sustaining Hyperactive Oncogenic Signaling
Authors: Hein Ashley L. , Seshacharyulu Parthasarathy , Rachagani Satyanarayana , Sheinin Yuri M. , Ouellette Michel M. , Ponnusamy Moorthy P. , Mumby Marc C. , Batra Surinder K. , Yan Ying
Published: April 2023

Effect of PR55Î± expression on clonogenicity of pancreatic cancer cells
Supplementary Tables S1-S4 from Dual Targeting of CDK4 and ARK5 Using a Novel Kinase Inhibitor ON123300 Exerts Potent Anticancer Activity against Multiple Myeloma
Authors: Perumal Deepak , Kuo Pei-Yu , Leshchenko Violetta V. , Jiang Zewei , Divakar Sai Krishna Athaluri , Cho Hearn Jay , Chari Ajai , Brody Joshua , Reddy M.V. Ramana , Zhang Weijia , Reddy E. Premkumar , Jagannath Sundar , Parekh Samir
Published: April 2023

Kinase Inhibition Profile of ON123300 and PD0332991 (S1); Top 10 significantly enriched pathways for the 894 differentially regulated genes from NCI-H929 siRNA RNA sequencing analysis (S2); Top 10 significantly enriched pathways for the 180 differentially regulated genes between ON123300 and resistant cell lines (S3); Top 10 significantly downregulated pathways for the 180 differentially regulated genes between ON123300 and resistant cell lines (S4).
Supplementary Figure S1 from PR55α Subunit of Protein Phosphatase 2A Supports the Tumorigenic and Metastatic Potential of Pancreatic Cancer Cells by Sustaining Hyperactive Oncogenic Signaling
Authors: Hein Ashley L. , Seshacharyulu Parthasarathy , Rachagani Satyanarayana , Sheinin Yuri M. , Ouellette Michel M. , Ponnusamy Moorthy P. , Mumby Marc C. , Batra Surinder K. , Yan Ying
Published: April 2023

Effect of PR55Î± expression on BAD and Î²-catenin
Supplementary Figures S1-S11 from Dual Targeting of CDK4 and ARK5 Using a Novel Kinase Inhibitor ON123300 Exerts Potent Anticancer Activity against Multiple Myeloma
Authors: Perumal Deepak , Kuo Pei-Yu , Leshchenko Violetta V. , Jiang Zewei , Divakar Sai Krishna Athaluri , Cho Hearn Jay , Chari Ajai , Brody Joshua , Reddy M.V. Ramana , Zhang Weijia , Reddy E. Premkumar , Jagannath Sundar , Parekh Samir
Published: April 2023

Mechanism of ON123300 induced MM cell death (S1); PD0332991 less significantly induces apoptosis in MM1.S cell and does not induce apotosis in NCI-H929 cells (S2); PD0332991 induces cell cycle arrest in MM1.S cells and not in NCI-H929 cells (S3); ON123300 induces cell cycle arrest in MM cells (S4); Molecular effects of treatment with PD0222991 in MM cell lines (S5); Effects of ARK5 depletion on MM cell viability by siRNA transfected MM1.S and NCI-H929 cells (S6); Anti-MM activity of SRT1720 (S7); Effect of ARK5 silencing by siRNA induces apoptosis in MM (S8); Effect of ARK5 silencing by siRNA enhances G1/S cell cycle arrest in MM (S9); ON123300 overcomes bone marrow stromal cell (BMSC) induced growth of MM Cells (S10); In vivo MM xenograft ON123300 inhibition (S11).
Supplemental Figure Legends from PR55α Subunit of Protein Phosphatase 2A Supports the Tumorigenic and Metastatic Potential of Pancreatic Cancer Cells by Sustaining Hyperactive Oncogenic Signaling
Authors: Hein Ashley L. , Seshacharyulu Parthasarathy , Rachagani Satyanarayana , Sheinin Yuri M. , Ouellette Michel M. , Ponnusamy Moorthy P. , Mumby Marc C. , Batra Surinder K. , Yan Ying
Published: April 2023

Legends for Supplementary Figures S1-S4
Supplementary Materials and Methods from Tissue Factor Induced by Epithelial–Mesenchymal Transition Triggers a Procoagulant State That Drives Metastasis of Circulating Tumor Cells
Authors: Bourcy Morgane , Suarez-Carmona Meggy , Lambert Justine , Francart Marie-Emilie , Schroeder Hélène , Delierneux Céline , Skrypek Nicolas , Thompson Erik W. , Jérusalem Guy , Berx Geert , Thiry Marc , Blacher Silvia , Hollier Brett G. , Noël Agnès , Oury Cécile , Polette Myriam , Gilles Christine
Published: April 2023

Supplementary Materials and Methods
Supplementary Figure S5 from Small-Molecule Prodigiosin Restores p53 Tumor Suppressor Activity in Chemoresistant Colorectal Cancer Stem Cells via c-Jun-Mediated ΔNp73 Inhibition and p73 Activation
Authors: Prabhu Varun V. , Hong Bo , Allen Joshua E. , Zhang Shengliang , Lulla Amriti R. , Dicker David T. , El-Deiry Wafik S.
Published: April 2023

Prodigiosin-mediated p53 pathway restoration, cell death and anti-CRCSC effect involves inhibition of Î”Np73.
Supplementary Table 1 from EGF816 Exerts Anticancer Effects in Non–Small Cell Lung Cancer by Irreversibly and Selectively Targeting Primary and Acquired Activating Mutations in the EGF Receptor
Authors: Jia Yong , Juarez Jose , Li Jie , Manuia Mari , Niederst Matthew J. , Tompkins Celin , Timple Noelito , Vaillancourt Mei-Ting , Pferdekamper AnneMarie Culazzo , Lockerman Elizabeth L. , Li Chun , Anderson Jennifer , Costa Carlotta , Liao Debbie , Murphy Eric , DiDonato Michael , Bursulaya Badry , Lelais Gerald , Barretina Jordi , McNeill Matthew , Epple Robert , Marsilje Thomas H. , Pathan Nuzhat , Engelman Jeffrey A. , Michellys Pierre-Yves , McNamara Peter , Harris Jennifer , Bender Steven , Kasibhatla Shailaja
Published: April 2023

This file contains the supplementary Table S1 that describes the characteristics and anti-proliferative activities of EGF816 on a number of patient-derived cell lines
Supplemental Figures 1-6 from Induction of Therapeutic Senescence in Vemurafenib-Resistant Melanoma by Extended Inhibition of CDK4/6
Authors: Yoshida Akihiro , Lee Eric K. , Diehl J. Alan
Published: April 2023

Supplemental figure 1-983BR and 1205LuR are resistant to vemurafenib. Cell cycle analysis of 983B, 983BR, 1205Lu, and 1205LuR cells treated with or without vemurafenib for 2 days by FACS. Supplemental Fig. 2 Inhibition of mTOR signaling pathway is critical for palbociclib-induced senescence in 983BR vemurafenib resistant cells, related to Figure. 6. Supplemental Fig. 3 Overexpression of mTOR signaling overrides palbociclib-induced senescence in 983BR vemurafenib resistant cells, related to Figure. 7. Supplemental Fig. 4 Rb expression in palbociclib resistant cells. Supplemental Fig. 5 Rapamycin negatively regulates geroconversion in esophageal cancer cell lines (referred to in discussion). Supplemental Fig. 6 Palbociclib has no cytotoxicity in 983BR vemurafenib resistant cells.
Supplementary Figure 4 from SIGMAR1 Regulates Membrane Electrical Activity in Response to Extracellular Matrix Stimulation to Drive Cancer Cell Invasiveness
Authors: Crottès David , Rapetti-Mauss Raphael , Alcaraz-Perez Francisca , Tichet Mélanie , Gariano Giuseppina , Martial Sonia , Guizouarn Hélène , Pellissier Bernard , Loubat Agnès , Popa Alexandra , Paquet Agnès , Presta Marco , Tartare-Deckert Sophie , Cayuela Maria Luisa , Martin Patrick , Borgese Franck , Soriani Olivier
Published: April 2023

Sig1R silencing inhibits CRC HCT-116 cell motility
Supplementary Table S4 from Loss of TGFβ Receptor Type 2 Expression Impairs Estrogen Response and Confers Tamoxifen Resistance
Authors: Busch Susann , Sims Andrew H. , Stål Olle , Fernö Mårten , Landberg Göran
Published: April 2023

Gene list of customized RT² Profiler PCR Array (SABiosciences).
Supplementary Figure S8 from Loss of TGFβ Receptor Type 2 Expression Impairs Estrogen Response and Confers Tamoxifen Resistance
Authors: Busch Susann , Sims Andrew H. , Stål Olle , Fernö Mårten , Landberg Göran
Published: April 2023

Survival outcome according to ERα status in invasive breast cancer.
Supplemental Figures Legends from SIRT2-Mediated Deacetylation and Tetramerization of Pyruvate Kinase Directs Glycolysis and Tumor Growth
Authors: Park Seong-Hoon , Ozden Ozkan , Liu Guoxiang , Song Ha Yong , Zhu Yueming , Yan Yufan , Zou Xianghui , Kang Hong-Jun , Jiang Haiyan , Principe Daniel R. , Cha Yong-Il , Roh Meejeon , Vassilopoulos Athanassios , Gius David
Published: April 2023

Supplemental figure legends for supplemental figures S1-S5.
Supplementary Figure 2 from NFAT1 Directly Regulates IL8 and MMP3 to Promote Melanoma Tumor Growth and Metastasis
Authors: Shoshan Einav , Braeuer Russell R. , Kamiya Takafumi , Mobley Aaron K. , Huang Li , Vasquez Mayra E. , Velazquez-Torres Guermarie , Chakravarti Nitin , Ivan Cristina , Prieto Victor , Villares Gabriel J. , Bar-Eli Menashe
Published: April 2023

Relative mRNA expression of NFAT1, IL-8, and MMP-3
Supplementary Figure 1 from NFAT1 Directly Regulates IL8 and MMP3 to Promote Melanoma Tumor Growth and Metastasis
Authors: Shoshan Einav , Braeuer Russell R. , Kamiya Takafumi , Mobley Aaron K. , Huang Li , Vasquez Mayra E. , Velazquez-Torres Guermarie , Chakravarti Nitin , Ivan Cristina , Prieto Victor , Villares Gabriel J. , Bar-Eli Menashe
Published: April 2023

Effect of NFAT1 silencing or overexpression on melanoma cell viability
Supplementary Figure 1 from Alox5 Blockade Eradicates JAK2V617F-Induced Polycythemia Vera in Mice
Authors: Chen Yaoyu , Shan Yi , Lu Min , DeSouza Ngoc , Guo Zhiru , Hoffman Ronald , Liang Aibin , Li Shaoguang
Published: April 2023

Supplemental Figure 1. Comparison of transduction efficiency of JAK2V617F retrovirus between WT and Alox5-/- donor bone marrow cells. Bone marrow cells from WT or Alox5-/- donor mice were transduced with JAK2V617F retrovirus, and transduced with the same virus again 24 hours later. Prior to injection into recipient mice, the percentages of GFP+ cells were analyzed by FACS. Some cells were cultured for two more days (72 hours after initial viral transduction), and then the percentages of GFP+ cells were analyzed.
Supplementary Table S3 from Hemolytic E. coli Promotes Colonic Tumorigenesis in Females
Authors: Jin Ye , Tang Senwei , Li Weilin , Ng Siew Chien , Chan Michael W.Y. , Sung Joseph J.Y. , Yu Jun
Published: April 2023

Cancer-associated gene fold regulation by E. coli strains in the NCM460 cell line, identified using the Human Cancer PathwayFinder (TM) RT2 Profiler (TM) PCR Array
Supplementary Table S1 from Hemolytic E. coli Promotes Colonic Tumorigenesis in Females
Authors: Jin Ye , Tang Senwei , Li Weilin , Ng Siew Chien , Chan Michael W.Y. , Sung Joseph J.Y. , Yu Jun
Published: April 2023

Clinical data of patients with CRC, adenomas, and healthy subjects in the search for CRC-associated fecal E. coli
Supplementary Tables 1 though 7 from Balancing Protein Stability and Activity in Cancer: A New Approach for Identifying Driver Mutations Affecting CBL Ubiquitin Ligase Activation
Authors: Li Minghui , Kales Stephen C. , Ma Ke , Shoemaker Benjamin A. , Crespo-Barreto Juan , Cangelosi Andrew L. , Lipkowitz Stanley , Panchenko Anna R.
Published: April 2023

Table S1. Classification of mutations and definition of different classes. Table S2. P-values for different null hypotheses calculated by two-sample t-test. Table S3. Top 25% cancer mutations with the largest energy changes for each state in CBL activation cycle. Table S4. Binding free energy for wild-type CBL-E2-S and pCBL-E2-S states. Table S5. Pearson correlation coefficients (R) between experimental densitometry values and predicted changes in stability and binding affinity. Table S6. True positive rates are listed corresponding to different false positive rates. Table S7. Experimental relative densitometry values for HEK293T cell line, predicted changes in stability, binding affinity and comparison with other methods for 15 experimentally tested mutations.
Supplementary Figure S3 from Hemolytic E. coli Promotes Colonic Tumorigenesis in Females
Authors: Jin Ye , Tang Senwei , Li Weilin , Ng Siew Chien , Chan Michael W.Y. , Sung Joseph J.Y. , Yu Jun
Published: April 2023

Requirement of FimH for colonization of hly+ type 1-E. coli in the colon of mice. (A) Colonization and persistence of J47, J47Î"hly and J47Î"fimH in the colon of wild-type BALB/c mice, as revealed by the number of the fed bacteria in stools. The bacteria number was determined by counting colony forming units (CFU). (B) Colonization of J47 and J47Î"hly in colonic mucosa of mice as revealed by percentage of the fed bacteria in total mucosa E. coli. ns, not significantly different; *P < 0.05; **P < 0.01.
Supplementary Methods from AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models
Authors: Weir Hazel M. , Bradbury Robert H. , Lawson Mandy , Rabow Alfred A. , Buttar David , Callis Rowena J. , Curwen Jon O. , de Almeida Camila , Ballard Peter , Hulse Michael , Donald Craig S. , Feron Lyman J.L. , Karoutchi Galith , MacFaul Philip , Moss Thomas , Norman Richard A. , Pearson Stuart E. , Tonge Michael , Davies Gareth , Walker Graeme E. , Wilson Zena , Rowlinson Rachel , Powell Steve , Sadler Claire , Richmond Graham , Ladd Brendon , Pazolli Ermira , Mazzola Anne Marie , D'Cruz Celina , De Savi Chris
Published: April 2023

Methods are given for: the use of SILAC assays to measure the rate of estrogen receptor α peptide degradation over time, the measurement of compound binding affinity of estrogen receptor α ligand binding domain using BIAcore, immunoblotting of estrogen and progesterone receptor proteins, RNA extraction and transcript analysis of estrogen receptor regulated genes, rat uterine model and human breast xenograft model studies, analysis of proteins from tumour fragments and measurement of compound concentration in animal models.
Supplementary Figures from AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models
Authors: Weir Hazel M. , Bradbury Robert H. , Lawson Mandy , Rabow Alfred A. , Buttar David , Callis Rowena J. , Curwen Jon O. , de Almeida Camila , Ballard Peter , Hulse Michael , Donald Craig S. , Feron Lyman J.L. , Karoutchi Galith , MacFaul Philip , Moss Thomas , Norman Richard A. , Pearson Stuart E. , Tonge Michael , Davies Gareth , Walker Graeme E. , Wilson Zena , Rowlinson Rachel , Powell Steve , Sadler Claire , Richmond Graham , Ladd Brendon , Pazolli Ermira , Mazzola Anne Marie , D'Cruz Celina , De Savi Chris
Published: April 2023

Supplementary Figure 1 contains a Western blot showing the amount of estrogen receptor remaining after treatment of MCF-7 cells with AZD9496, fulvestrant and estradiol alongside GAPDH protein levels as an internal gel loading control; Supplementary Figure 2 shows the rate of decreased detection by mass spectrometry of an estrogen receptor heavy isotype labelled peptide over time after treatment of cells with AZD9496, fulvestrant and tamoxifen and the calculated half life; Supplementary Figure 3 shows the degradation of estrogen receptor α by AZD9496, fulvestrant and estradiol in the presence of +/- 10 μM proteosomal inhibitor MG132; Supplementary Figure 4 contains a Western blot showing the re-emergence over 48 hours of estrogen receptor α following removal of AZD9496, fulvestrant and estradiol compounds from MCF-7 cells; Supplementary Figure 5 shows a bar chart of the measured estradiol levels in the blood of mice over 42 days after implantation of the mice with estrogen pellets to support growth of the MCF-7 cells as a tumour in mice; Supplementary Figure 6 shows the effects of AZD9496, fulvestrant and tamoxifen on mRNA levels of estrogen receptor regulated genes in vitro and in vivo; Supplementary Figure 7 shows the levels of estrogen receptor α protein remaining in tumours from the HCC1428 LTED model after treatment with AZD9496 and fulvestrant.
Supplementary Figure Legends from AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models
Authors: Weir Hazel M. , Bradbury Robert H. , Lawson Mandy , Rabow Alfred A. , Buttar David , Callis Rowena J. , Curwen Jon O. , de Almeida Camila , Ballard Peter , Hulse Michael , Donald Craig S. , Feron Lyman J.L. , Karoutchi Galith , MacFaul Philip , Moss Thomas , Norman Richard A. , Pearson Stuart E. , Tonge Michael , Davies Gareth , Walker Graeme E. , Wilson Zena , Rowlinson Rachel , Powell Steve , Sadler Claire , Richmond Graham , Ladd Brendon , Pazolli Ermira , Mazzola Anne Marie , D'Cruz Celina , De Savi Chris
Published: April 2023

Legends for Supplementary Figures 1 - 7.
Supplementary Table and Figure Legends from Comprehensive Ex Vivo Transposon Mutagenesis Identifies Genes That Promote Growth Factor Independence and Leukemogenesis
Authors: Guo Yabin , Updegraff Barrett L. , Park Sunho , Durakoglugil Deniz , Cruz Victoria H. , Maddux Sarah , Hwang Tae Hyun , O'Donnell Kathryn A.
Published: April 2023

Legends for Supplementary Tables S1-S4 and Supplementary Figures S1-S13.
Supplementary Table S1 from Macrophage Infiltration and Alternative Activation during Wound Healing Promote MEK1-Induced Skin Carcinogenesis
Authors: Weber Christine , Telerman Stephanie B. , Reimer Andreas S. , Sequeira Ines , Liakath-Ali Kifayathullah , Arwert Esther N. , Watt Fiona M.
Published: April 2023

List of all Taqman probes used during qPCR
Supplementary Figure Legends from p73 and IGF1R Regulate Emergence of Aggressive Cancer Stem–like Features via miR-885-5p Control
Authors: Meier Claudia , Hardtstock Philip , Joost Sophie , Alla Vijay , Pützer Brigitte M.
Published: April 2023

Legends for supplementary figures S1, S2, and S3.
Supplementary Table S11 from Transcriptome Analysis of Recurrently Deregulated Genes across Multiple Cancers Identifies New Pan-Cancer Biomarkers
Authors: Kaczkowski Bogumil , Tanaka Yuji , Kawaji Hideya , Sandelin Albin , Andersson Robin , Itoh Masayoshi , Lassmann Timo , Hayashizaki Yoshihide , Carninci Piero , Forrest Alistair R.R.
Published: April 2023

Summary of the enhancerRNAs detected as differentially expressed in the FANTOM5 analysis and those associated with transcript models from miTranscriptome.
Supplementary Movie 1 from Modeling Spontaneous Metastasis following Surgery: An In Vivo-In Silico Approach
Authors: Benzekry Sebastien , Tracz Amanda , Mastri Michalis , Corbelli Ryan , Barbolosi Dominique , Ebos John M.L.
Published: April 2023

Supplementary Movie 1: Primary tumor (PT) was assumed to be detected when reaching the size of 4.32 cm in diameter. Post-diagnosis PT growth and development of metastases in the case of no surgical intervention are indicated as dashed line in the left plot and white bars in the histogram on the right, respectively.
Supplementary Table S1 from Transcriptome Analysis of Recurrently Deregulated Genes across Multiple Cancers Identifies New Pan-Cancer Biomarkers
Authors: Kaczkowski Bogumil , Tanaka Yuji , Kawaji Hideya , Sandelin Albin , Andersson Robin , Itoh Masayoshi , Lassmann Timo , Hayashizaki Yoshihide , Carninci Piero , Forrest Alistair R.R.
Published: April 2023

List of all samples from FANTOM5 CAGE data.
Supplementary Figure 4 from miR-34a Silences c-SRC to Attenuate Tumor Growth in Triple-Negative Breast Cancer
Authors: Adams Brian D. , Wali Vikram B. , Cheng Christopher J. , Inukai Sachi , Booth Carmen J. , Agarwal Seema , Rimm David L. , Győrffy Balázs , Santarpia Libero , Pusztai Lajos , Saltzman W. Mark , Slack Frank J.
Published: April 2023

Figure S4, Related to Figure 5. A-F, Further characterization of c-SRC siRNA treatments in TNBC cell lines. A, Crystal violet staining of MDA-MB-231 and Hs578T cells post 15nM si-SRC and si-Neg transfection (Day 6 images, left panel), and quantification of staining abundance is shown on right panels). B, SRB results on Hs578T cell line. C, Analysis of a second siRNA to c-SRC in MDA-MB-231 cells. SRB assays are shown in the left panel and western blot analysis confirming c-SRC knockdown (72 hour post-transfection) is shown on the right panel. D, Crystal violet staining of HFF cells. E, SA-β-gal assays in the indicated cell lines 5 days after 15nM si-SRC transfection. F, miR-34a levels 72 hours after 15nM si-SRC transfection in Hs578T cells. G, Assessment of SRC mRNA levels in the indicated cell lines 72 hours after 15nM si-SRC transfection.
Supplementary Figure 3 from miR-34a Silences c-SRC to Attenuate Tumor Growth in Triple-Negative Breast Cancer
Authors: Adams Brian D. , Wali Vikram B. , Cheng Christopher J. , Inukai Sachi , Booth Carmen J. , Agarwal Seema , Rimm David L. , Győrffy Balázs , Santarpia Libero , Pusztai Lajos , Saltzman W. Mark , Slack Frank J.
Published: April 2023

Figure S3, Related to Figure 4. A, c-SRC expression in normal (HFF and MCF-10A), luminal-A (MCF-7), LAR-TNBC (MDA-MB-453), and mesenchymal-TNBC (MDA-MB-231, BT-549, and Hs578T) cell lines. Expression was normalized to GAPDH and made relative to c-SRC expression in HFF lines. B-C, Clonogenic assays in Hs578T (B), and MDA-MB-436 (C) TNBC cells after miR-34a transfection and treatment with Dasatnib (left panels) and paclitaxel (right panel) or as a control HeLa cells after dasatinib treatment (C, right panel). D-E, Assessment of miR-34a target genes in MDA-MB-231 cells after 72 hours of dasatinib treatment (D), or miR-34a levels after 72 hours paclitaxel treatment (E). F, miR-34a promoter luciferase assays in MDA-MB-31 cells after dasatinib treatment. G-H, Spearman rank correlation analysis of SRC levels in cell lines described in Figure 1A (G), and in all breast cancer samples in the Metabric dataset (H). I, Comparable decreases in phospho-Tyr416 active c-SRC, non-phospho-Tyr527 c-SRC, and total c-SRC are observed in MDA-MB-231 cells transfected with 15nM miR-34a versus miR-Scr control, as determined by Western blot analysis. J, Schematic highlighting the miR-34a-c-SRC double-negative feedback loop present in MSL TNBC cells, which can be influenced by exogenous addition of miR-34a, or by dasatinib treatment. * Indicates p<0.05, as compared to control conditions.
Supplementary_siNRP2 autophagy from Neuropilin-2 Regulates Endosome Maturation and EGFR Trafficking to Support Cancer Cell Pathobiology
Authors: Dutta Samikshan , Roy Sohini , Polavaram Navatha S. , Stanton Marissa J. , Zhang Heyu , Bhola Tanvi , Hönscheid Pia , Donohue Terrence M. , Band Hamid , Batra Surinder K. , Muders Michael H. , Datta Kaustubh
Published: April 2023

Autophagy_live cell
Supplementary Figure Legends from Neuropilin-2 Regulates Endosome Maturation and EGFR Trafficking to Support Cancer Cell Pathobiology
Authors: Dutta Samikshan , Roy Sohini , Polavaram Navatha S. , Stanton Marissa J. , Zhang Heyu , Bhola Tanvi , Hönscheid Pia , Donohue Terrence M. , Band Hamid , Batra Surinder K. , Muders Michael H. , Datta Kaustubh
Published: April 2023

Supplementary figure legends
Supplementary Figure S3 from Eva1 Maintains the Stem-like Character of Glioblastoma-Initiating Cells by Activating the Noncanonical NF-κB Signaling Pathway
Authors: Ohtsu Naoki , Nakatani Yuka , Yamashita Daisuke , Ohue Shiro , Ohnishi Takanori , Kondo Toru
Published: April 2023

Knockdown efficiency of eva1sh-expression vectors.
Supplementary Figure S1 from Effective Targeting of the Survivin Dimerization Interface with Small-Molecule Inhibitors
Authors: Qi Jing , Dong Zizheng , Liu Jianguo , Peery Robert C. , Zhang Shaobo , Liu Jing-Yuan , Zhang Jian-Ting
Published: April 2023

Effect of compounds from in-silico screening on cancer cell survival.
Supplementary Figure S5 from Rapalogs Efficacy Relies on the Modulation of Antitumor T-cell Immunity
Authors: Beziaud Laurent , Mansi Laura , Ravel Patrice , Marie-Joseph Elodie Lauret , Laheurte Caroline , Rangan Laurie , Bonnefoy Francis , Pallandre Jean-René , Boullerot Laura , Gamonet Clémentine , Vrecko Sindy , Queiroz Lise , Maurina Tristan , Mouillet Guillaume , Hon Thierry Nguyen Tan , Curtit Elsa , Royer Bernard , Gaugler Béatrice , Bayry Jagadeesh , Tartour Eric , Thiery-Vuillemin Antoine , Pivot Xavier , Borg Christophe , Godet Yann , Adotévi Olivier
Published: April 2023

This file contains contains CD8 responses in immune groups: Supplementary figure 5
Supplementary Figure S6 from Upregulation of Cytosolic Phosphoenolpyruvate Carboxykinase Is a Critical Metabolic Event in Melanoma Cells That Repopulate Tumors
Authors: Li Yong , Luo Shunqun , Ma Ruihua , Liu Jing , Xu Pingwei , Zhang Huafeng , Tang Ke , Ma Jingwei , Zhang Yi , Liang Xiaoyu , Sun Yanling , Ji Tiantian , Wang Ning , Huang Bo
Published: April 2023

Supplementary Figure S6. TRCs lost PCK1 expression in conventional rigid dish and inhibition of PCK1 enzymatic activity resulted in the decrease of bulk tumor cell number.
Supplementary Figure S2 from Upregulation of Cytosolic Phosphoenolpyruvate Carboxykinase Is a Critical Metabolic Event in Melanoma Cells That Repopulate Tumors
Authors: Li Yong , Luo Shunqun , Ma Ruihua , Liu Jing , Xu Pingwei , Zhang Huafeng , Tang Ke , Ma Jingwei , Zhang Yi , Liang Xiaoyu , Sun Yanling , Ji Tiantian , Wang Ning , Huang Bo
Published: April 2023

Supplementary Figure S2. The expression of PCK1 in CD133+ B16 cells, human primary melanoma TRCs and melanoma tissues.
Supplemental Data from Multinucleation and Mesenchymal-to-Epithelial Transition Alleviate Resistance to Combined Cabazitaxel and Antiandrogen Therapy in Advanced Prostate Cancer
Authors: Martin Sarah K. , Pu Hong , Penticuff Justin C. , Cao Zheng , Horbinski Craig , Kyprianou Natasha
Published: April 2023

Legends for supplemental figures
Supplementary Figure S1 from Upregulation of Cytosolic Phosphoenolpyruvate Carboxykinase Is a Critical Metabolic Event in Melanoma Cells That Repopulate Tumors
Authors: Li Yong , Luo Shunqun , Ma Ruihua , Liu Jing , Xu Pingwei , Zhang Huafeng , Tang Ke , Ma Jingwei , Zhang Yi , Liang Xiaoyu , Sun Yanling , Ji Tiantian , Wang Ning , Huang Bo
Published: April 2023

Supplementary Figure S1. The silence efficiency of siRNA against G9a, SUV39h1 or PCK1 and identification of constructs.
Supplementary Figure Legends from Upregulation of Cytosolic Phosphoenolpyruvate Carboxykinase Is a Critical Metabolic Event in Melanoma Cells That Repopulate Tumors
Authors: Li Yong , Luo Shunqun , Ma Ruihua , Liu Jing , Xu Pingwei , Zhang Huafeng , Tang Ke , Ma Jingwei , Zhang Yi , Liang Xiaoyu , Sun Yanling , Ji Tiantian , Wang Ning , Huang Bo
Published: April 2023

Legends for Supplementary Figures S1-S8.
Supplementary Figures S1-S2 from The Proliferative Activity of Mammary Epithelial Cells in Normal Tissue Predicts Breast Cancer Risk in Premenopausal Women
Authors: Huh Sung Jin , Oh Hannah , Peterson Michael A. , Almendro Vanessa , Hu Rong , Bowden Michaela , Lis Rosina L. , Cotter Maura B. , Loda Massimo , Barry William T. , Polyak Kornelia , Tamimi Rulla M.
Published: April 2023

Image analysis of benign breast lesions (S1); Boxplots of the percentage of p27+, ER+, and Ki67+ cells in benign breast lesions (S2).
Supplemental Materials and Methods from EGFR Signaling Enhances Aerobic Glycolysis in Triple-Negative Breast Cancer Cells to Promote Tumor Growth and Immune Escape
Authors: Lim Seung-Oe , Li Chia-Wei , Xia Weiya , Lee Heng-Huan , Chang Shih-Shin , Shen Jia , Hsu Jennifer L. , Raftery Daniel , Djukovic Danijel , Gu Haiwei , Chang Wei-Chao , Wang Hung-Ling , Chen Mong-Liang , Huo Longfei , Chen Chung-Hsuan , Wu Yun , Sahin Aysegul , Hanash Samir M. , Hortobagyi Gabriel N. , Hung Mien-Chie
Published: April 2023

Supplemental Materials and Methods
Supplementary Figures 1-6 from Peptide–Drug Conjugate GnRH–Sunitinib Targets Angiogenesis Selectively at the Site of Action to Inhibit Tumor Growth
Authors: Argyros Orestis , Karampelas Theodoros , Asvos Xenophon , Varela Aimilia , Sayyad Nisar , Papakyriakou Athanasios , Davos Constantinos H. , Tzakos Andreas G. , Fokas Demosthenes , Tamvakopoulos Constantin
Published: April 2023

Supplementary Figures 1-6. Figure S.I.1 - 1HNMR spectra of the six sunitinib analogues Figure S.I.2 - LC-MS/MS characterization of SAN1 Figure S.I.3 - Molecular models of VEGFR-2 kinase domain complexed with SAN1,2,3 Figure S.I.4 - Synthesis and characterization of SAN1GSC by NMR and LC-MS/MS Figure S.I.5 - Body weights of xenografted mice during the course of treatment Figure S.I.6 - Evaluation of the hematological toxicities following treatment
Supplemental Table 1 from Dietary Microbes Modulate Transgenerational Cancer Risk
Authors: Poutahidis Theofilos , Varian Bernard J. , Levkovich Tatiana , Lakritz Jessica R. , Mirabal Sheyla , Kwok Caitlin , Ibrahim Yassin M. , Kearney Sean M. , Chatzigiagkos Antonis , Alm Eric J. , Erdman Susan E.
Published: April 2023

Nutritional profile of special diets fed to mice.
Supplemental Figure 2 from Dietary Microbes Modulate Transgenerational Cancer Risk
Authors: Poutahidis Theofilos , Varian Bernard J. , Levkovich Tatiana , Lakritz Jessica R. , Mirabal Sheyla , Kwok Caitlin , Ibrahim Yassin M. , Kearney Sean M. , Chatzigiagkos Antonis , Alm Eric J. , Erdman Susan E.
Published: April 2023

Control and NWD-treated mice cluster separately by microbiota. NWD-treated mice carry fewer Bacteroidetes in general than their control diet-fed counterparts. Overall, there is a shift towards higher abundance of OTUs from the Firmicutes phyla and decrease in OTUs from the Bacteroidetes phyla in mice treated with NWD. These data are consistent with previous findings of elevation of Firmicutes to Bacteroidetes phyla in obese mice.
Supplementary Table S2 from Decreased Expression of Fructose-1,6-bisphosphatase Associates with Glucose Metabolism and Tumor Progression in Hepatocellular Carcinoma
Authors: Hirata Hidenari , Sugimachi Keishi , Komatsu Hisateru , Ueda Masami , Masuda Takaaki , Uchi Ryutaro , Sakimura Shotaro , Nambara Sho , Saito Tomoko , Shinden Yoshiaki , Iguchi Tomohiro , Eguchi Hidetoshi , Ito Shuhei , Terashima Kotaro , Sakamoto Katsumi , Hirakawa Masakazu , Honda Hiroshi , Mimori Koshi
Published: April 2023

Promoter methylation and copy number profiles of FBP1 in liver cancer cell lines from the Cancer Cell Line Encyclopedia.
Supplemental Figure 1 from Dietary Microbes Modulate Transgenerational Cancer Risk
Authors: Poutahidis Theofilos , Varian Bernard J. , Levkovich Tatiana , Lakritz Jessica R. , Mirabal Sheyla , Kwok Caitlin , Ibrahim Yassin M. , Kearney Sean M. , Chatzigiagkos Antonis , Alm Eric J. , Erdman Susan E.
Published: April 2023

(A) Selected immunohistochemical features of transgenerational neoplasms including TTF1 immunoreactivity of pulmonary carcinoma, Von Willebrand factor expression of hepatic hemagiosarcoma and high numbers of proliferating ki-67-positive cells of theca cell tumor of the ovary. Foci of neoplastic cells with nuclear p53 accumulation in hepatocellular carcinoma (left), pulmonary carcinoma (middle) and ovarian thecoma (right panel). (B) Histology of underrepresented transgenerational cancers. Typical histomorphology of islet cell adenoma of pancreas, ovarian granulosa cell tumor and skin lymphoma. (C) Tabular display of lung and liver tumor types according to treatment. IHC; Di-aminobenzidine chromogen, Hematoxylin counterstain. (A). Hematoxylin and Eosin (B).
Supplementary Table S1 from Decreased Expression of Fructose-1,6-bisphosphatase Associates with Glucose Metabolism and Tumor Progression in Hepatocellular Carcinoma
Authors: Hirata Hidenari , Sugimachi Keishi , Komatsu Hisateru , Ueda Masami , Masuda Takaaki , Uchi Ryutaro , Sakimura Shotaro , Nambara Sho , Saito Tomoko , Shinden Yoshiaki , Iguchi Tomohiro , Eguchi Hidetoshi , Ito Shuhei , Terashima Kotaro , Sakamoto Katsumi , Hirakawa Masakazu , Honda Hiroshi , Mimori Koshi
Published: April 2023

Copy number and expression profiles of FBP1 in liver cancer cell lines from the Cancer Cell Line Encyclopedia.
Supplemental Figures S1-S5 from JARID1D Is a Suppressor and Prognostic Marker of Prostate Cancer Invasion and Metastasis
Authors: Li Na , Dhar Shilpa S. , Chen Tsai-Yu , Kan Pu-Yeh , Wei Yongkun , Kim Jae-Hwan , Chan Chia-Hsin , Lin Hui-Kuan , Hung Mien-Chie , Lee Min Gyu
Published: April 2023

Analysis of JARID1A-D mRNA levels showed that JARID1D knockdown had insignificant or weak effects on expression levels of JARID1A-C (S1); Gene ontology analysis for genes down-regulated in JARID1D-depleted cells (S2); Heatmap for H3K4me3 ChIP-Seq signals of all the gene-regulatory regions spanning âˆ’ 2kb to +2kb suggested that many H3K4me3 signals were slightly increased by JARID1D knockdown. (S3); Of JARID1A-1D, only JARID1D mRNA levels were downregulated in metastasis tumors compared to primary tumors (S4); JARID1D mRNA levels were not correlated with MMP2 (S5).
Supplementary Tables 1-7 from Establishment and Characterization of an In Vitro Model of Ovarian Cancer Stem-like Cells with an Enhanced Proliferative Capacity
Authors: Ishiguro Tatsuya , Sato Ai , Ohata Hirokazu , Ikarashi Yoshinori , Takahashi Ryou-u , Ochiya Takahiro , Yoshida Masayuki , Tsuda Hitoshi , Onda Takashi , Kato Tomoyasu , Kasamatsu Takahiro , Enomoto Takayuki , Tanaka Kenichi , Nakagama Hitoshi , Okamoto Koji
Published: April 2023

Supplementary Table S1. Information on clinical data of SOCs and sphere formation. Supplementary Table S2. Xenograft tumor formation assay of the ovarian spheroids (#4). Supplementary Table S3. Limited dilution assay on the FACS-sorted spheroid cells. Supplementary Table S4. Clinicopathological features of high-grade serous ovarian carcinoma patients. Supplementary Table S5. Statistical analyses of ALDH1A1 expression in advanced-stage high-grade serous ovarian carcinoma. Supplementary Table S6. Limited dilution assays for the sh-ALDH1A1-infected cells. Supplementary Table S7. Limited dilution assays for the sh-SOX2-infected cells.
Legends for Figures S1-S7 from Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates β-Catenin Signaling and Tumorigenesis in Multiple Cancer Types
Authors: Chartier Cecile , Raval Janak , Axelrod Fumiko , Bond Chris , Cain Jennifer , Dee-Hoskins Cristina , Ma Shirley , Fischer Marcus M. , Shah Jalpa , Wei Jie , Ji May , Lam Andrew , Stroud Michelle , Yen Wan-Ching , Yeung Pete , Cancilla Belinda , O'Young Gilbert , Wang Min , Kapoun Ann M. , Lewicki John , Hoey Timothy , Gurney Austin
Published: April 2023

Supplemental figure legends also include brief methods where appropriate.
Table S1 from Non–Small Cell Lung Cancer Cells Acquire Resistance to the ALK Inhibitor Alectinib by Activating Alternative Receptor Tyrosine Kinases
Authors: Isozaki Hideko , Ichihara Eiki , Takigawa Nagio , Ohashi Kadoaki , Ochi Nobuaki , Yasugi Masayuki , Ninomiya Takashi , Yamane Hiromichi , Hotta Katsuyuki , Sakai Katsuya , Matsumoto Kunio , Hosokawa Shinobu , Bessho Akihiro , Sendo Toshiaki , Tanimoto Mitsune , Kiura Katsuyuki
Published: April 2023

Antibodies
Supplementary Method, Supplementary Tables, and Supplementary Figures from Photodynamic Therapy Synergizes with Irinotecan to Overcome Compensatory Mechanisms and Improve Treatment Outcomes in Pancreatic Cancer
Authors: Huang Huang-Chiao , Mallidi Srivalleesha , Liu Joyce , Chiang Chun-Te , Mai Zhiming , Goldschmidt Ruth , Ebrahim-Zadeh Neema , Rizvi Imran , Hasan Tayyaba
Published: April 2023

(i) Supplementary Methods 1. Synthesis of L-BPD and L-IRI via freeze-thaw extrusion method 2. Pharmacokinetics and biodistribution of L-BPD and L-IRI 3. In-vitro quantification of changes in ABCG2 expression using immunofluorescence 4. Ultrasound Imaging 5. Histology and immunofluorescence of tumor samples 6. Quantification of H&E and immunofluorescence biomarkers 7. Determination of Synergism (ii) Supplementary Tables Supplementary Table S1. Comparison of PDT and irinotecan doses used in this study versus in clinic Supplementary Table S2. List of antibodies used for immunofluorescence Supplementary Table S3. The synergistic effect of combination PDT and L-IRI Supplementary Table S4. Physical parameters of L-BPD and L-IRI (iii) Supplementary Figures and Legends Supplementary Fig. S1. Treatment schedule and longitudinal monitoring of PanCa tumors in vivo Supplementary Fig. S2. Sub-cytotoxic PDT leads to decreased levels of ABCG2 and increased intracellular irinotecan in AsPC-1 cells Supplementary Fig. S3. Tumor growth kinetics of MIA PACa-2 and AsPC-1 in vivo Supplementary Fig. S4. Change in mouse body weight after combination treatment
Suppl. Figure 8 from Non–Small Cell Lung Cancer Cells Acquire Resistance to the ALK Inhibitor Alectinib by Activating Alternative Receptor Tyrosine Kinases
Authors: Isozaki Hideko , Ichihara Eiki , Takigawa Nagio , Ohashi Kadoaki , Ochi Nobuaki , Yasugi Masayuki , Ninomiya Takashi , Yamane Hiromichi , Hotta Katsuyuki , Sakai Katsuya , Matsumoto Kunio , Hosokawa Shinobu , Bessho Akihiro , Sendo Toshiaki , Tanimoto Mitsune , Kiura Katsuyuki
Published: April 2023

Long-term effects of crizotinib on tumor growth in xenograft models
Supplementary Figure S4 from Exosomes Derived from Hypoxic Oral Squamous Cell Carcinoma Cells Deliver miR-21 to Normoxic Cells to Elicit a Prometastatic Phenotype
Authors: Li Ling , Li Chao , Wang Shaoxin , Wang Zhaohui , Jiang Jian , Wang Wei , Li Xiaoxia , Chen Jin , Liu Kun , Li Chunhua , Zhu Guiquan
Published: April 2023

Role of circulating exosomes on cell migration and invasion of OSCC cells.
Supplementary Figure S3 from Exosomes Derived from Hypoxic Oral Squamous Cell Carcinoma Cells Deliver miR-21 to Normoxic Cells to Elicit a Prometastatic Phenotype
Authors: Li Ling , Li Chao , Wang Shaoxin , Wang Zhaohui , Jiang Jian , Wang Wei , Li Xiaoxia , Chen Jin , Liu Kun , Li Chunhua , Zhu Guiquan
Published: April 2023

miR-21 levels in exosomes derived from wild-type and miR-21 KD cells were measured by quantitative real-time PCR.
Supplementary Figure S2 from Exosomes Derived from Hypoxic Oral Squamous Cell Carcinoma Cells Deliver miR-21 to Normoxic Cells to Elicit a Prometastatic Phenotype
Authors: Li Ling , Li Chao , Wang Shaoxin , Wang Zhaohui , Jiang Jian , Wang Wei , Li Xiaoxia , Chen Jin , Liu Kun , Li Chunhua , Zhu Guiquan
Published: April 2023

miR-21 expression levels in exosomes and SCC-9 cells cultured under normoxia and hypoxia were measured by quantitative real-time PCR.
Supplementary Figure Legends from Exosomes Derived from Hypoxic Oral Squamous Cell Carcinoma Cells Deliver miR-21 to Normoxic Cells to Elicit a Prometastatic Phenotype
Authors: Li Ling , Li Chao , Wang Shaoxin , Wang Zhaohui , Jiang Jian , Wang Wei , Li Xiaoxia , Chen Jin , Liu Kun , Li Chunhua , Zhu Guiquan
Published: April 2023

Legend for Supplementary Figures S1-S4.
Supplementary Table and Figure Legends from Hypoxia-Induced Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma Induces an Immunosuppressive Tumor Microenvironment to Promote Metastasis
Authors: Ye Long-Yun , Chen Wei , Bai Xue-Li , Xu Xing-Yuan , Zhang Qi , Xia Xue-Feng , Sun Xu , Li Guo-Gang , Hu Qi-Da , Fu Qi-Han , Liang Ting-Bo
Published: April 2023

Legends for Supplementary Tables S1-S2 and Supplementary Figures S1-S6.
Supplemental Tables from Decoding Intratumoral Heterogeneity of Breast Cancer by Multiparametric In Vivo Imaging: A Translational Study
Authors: Schmitz Jennifer , Schwab Julian , Schwenck Johannes , Chen Qian , Quintanilla-Martinez Leticia , Hahn Markus , Wietek Beate , Schwenzer Nina , Staebler Annette , Kohlhofer Ursula , Aina Olulanu H. , Hubbard Neil E. , Reischl Gerald , Borowsky Alexander D. , Brucker Sara , Nikolaou Konstantin , la Fougère Christian , Cardiff Robert D. , Pichler Bernd J. , Schmid Andreas M.
Published: April 2023

Supplemental Table I is a list of abbreviations, Supplemental Table II contains the classification parameters for the different phenotypes in the mouse model and Supplemental Table III contains a summary of clinical data correlating image-derived and histology-derived tumor volumes.
Supplementary Table S1 from Hypoxia-Induced Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma Induces an Immunosuppressive Tumor Microenvironment to Promote Metastasis
Authors: Ye Long-Yun , Chen Wei , Bai Xue-Li , Xu Xing-Yuan , Zhang Qi , Xia Xue-Feng , Sun Xu , Li Guo-Gang , Hu Qi-Da , Fu Qi-Han , Liang Ting-Bo
Published: April 2023

Correlation between the expression level of CCL20 (low or high) and clinicopathologic characteristics in HCC patients.
Supplemental Figure I from Decoding Intratumoral Heterogeneity of Breast Cancer by Multiparametric In Vivo Imaging: A Translational Study
Authors: Schmitz Jennifer , Schwab Julian , Schwenck Johannes , Chen Qian , Quintanilla-Martinez Leticia , Hahn Markus , Wietek Beate , Schwenzer Nina , Staebler Annette , Kohlhofer Ursula , Aina Olulanu H. , Hubbard Neil E. , Reischl Gerald , Borowsky Alexander D. , Brucker Sara , Nikolaou Konstantin , la Fougère Christian , Cardiff Robert D. , Pichler Bernd J. , Schmid Andreas M.
Published: April 2023

Mean (blue) and maximal (red) ADC and [18F]FDG uptake values of the same representative 8 tumors: VOIs were drawn on the basis of the T2-weighted TSE MRI data, and transferred to the appropriate PET and ADC data. The mean and max values were determined. The comparison between mean or maximal values between the tumors revealed different trends.
Supplementary Figure S3 from Hypoxia-Induced Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma Induces an Immunosuppressive Tumor Microenvironment to Promote Metastasis
Authors: Ye Long-Yun , Chen Wei , Bai Xue-Li , Xu Xing-Yuan , Zhang Qi , Xia Xue-Feng , Sun Xu , Li Guo-Gang , Hu Qi-Da , Fu Qi-Han , Liang Ting-Bo
Published: April 2023

Monocytes co-cultured with hepatoma cells exhibit a higher level of expression of CD206 and CD163, indicating differentiation into suppressive MMs.
Supplementary Tables and Figures from AKT1 Inhibits Epithelial-to-Mesenchymal Transition in Breast Cancer through Phosphorylation-Dependent Twist1 Degradation
Authors: Li Chia-Wei , Xia Weiya , Lim Seung-Oe , Hsu Jennifer L. , Huo Longfei , Wu Yun , Li Long-Yuan , Lai Chien-Chen , Chang Shih-Shin , Hsu Yi-Hsin , Sun Hui-Lung , Kim Jongchan , Yamaguchi Hirohito , Lee Dung-Fang , Wang Hongmei , Wang Yan , Chou Chao-Kai , Hsu Jung-Mao , Lai Yun-Ju , LaBaff Adam M. , Ding Qingqing , Ko How-Wen , Tsai Fuu-Jen , Tsai Chang-Hai , Hortobagyi Gabriel N. , Hung Mien-Chie
Published: April 2023

Supplementary Table S1. Relationship between expression of AKT1, β-TrCP, Twist1, and E-cadherin in surgical specimens of breast cancer. Supplementary Table S2. Antibodies used in Western blotting and immunoprecipitation. Supplementary Figure S1. AKT1 is downregulated in aggressive breast cancer. Supplementary Figure S2. AKT1 preferentially interacts with Twist1. Supplementary Figure S3. AKT1 phosphorylates Twist1 at two putative motifs. Supplementary Figure S4. AKT1 induces β-TrCP mediated Twist1 degradation. Supplementary Figure S5. Twist1 AVA induces a stronger EMT phenotypic change. Supplementary Figure S6. Twist1 AVA induces a stronger EMT phenotypic change. Supplementary Figure S7. Clinical association of AKT1, β-TrCP, Twist1 and E-caherin expression in breast cancer patients. Supplementary Figure S8. MK-2206 induces EMT phenotypic change. Supplementary Figure S8. Clinical association of AKT1, β-TrCP, Twist1 and E-caherin expression in breast cancer patients. Supplementary Figure S9. MK-2206 induces EMT phenotypic change.