bluuebunny/crossref_metadata_2025 huggingface dataset:
TOWARDS A DIGITAL TWIN FOR HIGH-QUALITY CURING OF MULTIPLE COMPOSITE PARTS IN AUTOCLAVE
Authors: SHRESTHA KALYAN , KARUPPIAH ANAND , LIU NING , LUA JIM
Published: November 2023

Autoclave processes require a balance between the throughput and quality of the cured composite parts. The curing process is a major factor that influences the quality as well as the manufacturing time, which in turn is governed by the thermal distribution of the composite part. Developing a digital twin for composite curing in an autoclave is essential to optimize the autoclave process, which involves simultaneously curing multiple parts and improving the thermal homogeneity to obtain high-quality parts. A physics-based digital twin is created to mirror the physical composite curing process in the virtual domain. The digital twin includes a thermal CFD model, a thermo-chemo-mechanical module, and an efficient and accurate block coupling between these two modules. The customized Abaqus driven by local and spatial variation of the turbulence-induced heat transfer coefficient imposed through one-way coupling determines the thermo-mechanical response in composite parts. The accuracy of the one-way coupling strategy is demonstrated first using a benchmark problem followed by the capability demonstration with a single-part L-beam assembly. The benefits of using the digital twin tool are illustrated via the optimal placement of multiple parts in an autoclave to balance the throughput and quality.
Problemy z interpretacją fonologiczną samogłosek nosowych w języku polskim
Authors: Siudzińska Natalia
Published: November 2023

PROBLEMS WITH PHONOLOGICAL INTERPRETATION OF NASAL VOWELS IN POLISH
The article discusses problems related to the sound realisation of the nasal sounds “ą” and “ę” as well as the differences in the phonological interpretation of those realisations. The issue has been raised many times by linguistic researchers, which proves its complexity. The article is an overview as its main goal has been to compare suggestions in terms of the nasal phonemes range, including the author’s suggestion for the phonological interpretation of the second part of the biphonemic sound production of the sounds “ą” and “ę” using phonological opposition and sound distribution.
Specyfika staropolszczyzny a anotacja gramatyczna
Authors: Stelmach Wojciech , Wismont Magdalena , Zalejarz Kinga , Nowak-Pasterska Ewa , Rojszczak-Robińska Dorota
Published: November 2023

OLD POLISH LANGUAGE SPECIFICITY AND GRAMMATICAL ANNOTATION: TENSE AND MOOD CATEGORIES
This article is dedicated to the grammatical annotation of Old Polish texts. The problem with the annotation of tense and mood in medieval texts has been discussed. It results from the absence of the verb as a grammatical class, the varied ways of constructing the forms of tense and mood, and the mobility of the elements of these forms. Due to the difficulties related to the material studied, as well as technical issues, it was necessary to implement an additional level of annotation. The article discusses the rules of the second annotation, and identifies forms and constructions that are problematic to interpret in grammatical and syntactical basis. Differences in the way of understanding of agglutination category have been shown (in relation to other corpora of historical and contemporary texts). The work on the preparation of the “Tense and Mood” search engine has demonstrated that Old Polish apocryphal texts document the development of Polish verbal inflection.
Kalinowym mostem chodziłam, kalinowe serce zgubiłam. Kontynuacje i transformacje motywów ludowych w tekstach literackich
Authors: Niebrzegowska-Bartmińska Stanisława
Published: November 2023

KALINOWYM MOSTEM CHODZIŁAM, KALINOWE SERCE ZGUBIŁAM: CONTINUATIONS AND TRANSFORMATIONS OF FOLK MOTIFS IN LITERARY TEXTS
The author analyzes the relationship between the folk images of viburnum, viburnum bridge and viburnum grove, as they all are reconstructed in the Lublin ethnolinguistic dictionary, and viburnum motifs identified in five selected literary texts: Teofil Lenartowicz’ Kalina ‘Viburnum’ (1845), Wincenty Korotyński’s Two Loves (1857), Krystyna Krahelska’s Kalinowym mostem chodziłam ‘I Used to Walk over the Viburnum Bridge’ (1941), Andrzej Trzebiński’s Wymarsz Uderzenia (1943) and Tadeusz Urgacz’ Kalinowe serce ‘Viburnum Heart’ (1961). As a result, both continuation and transformation of folk motifs can be detected. What connects the “Viburnum” motifs and the images created from them in the literary works representing different eras, times and styles is the world of values communicated by means of a symbol. The recurring value, as projected here in/by the central symbol of the viburnum, appears to be love.
libre autodeterminación de los pueblos como paradoja internacional:
Authors: Cortés Ballén Diego Rodrigo
Published: November 2023

El presente trabajo analiza el principio de la libre autodeterminación de los pueblos desde una perspectiva crítica como una norma internacional utilizada con propósitos de dominio hegemónico. Con este fin se analizan en primer lugar su génesis política y normativa, su alcance conceptual, los contornos del principio, distinguiéndole del concepto de soberanía, y el reconocimiento expreso que se ha hecho de este en el seno de la comunidad internacional. A continuación, se desentrañan y exponen los diferentes escenarios en los que el principio adquiere utilidad en la comunidad internacional, desde una óptica operativa, para abordar de manera consecuente su uso legitimante en el contexto del reconocimiento ruso de las regiones separatistas de Abjasia y Osetia del sur en la República de Georgia, la anexión rusa de la península ucraniana de Crimea, y el actual conflicto internacional entre la República de Ucrania y la Federación Rusa, deteniéndonos en el análisis de la libre autodeterminación de los pueblos desde una perspectiva soviética. Por último, se exponen las conclusiones obtenidas del análisis realizado.
Pandemia y pobreza en Colombia
Authors: Ariza John , Saldarriaga Muñoz Juan Pablo , Retajac Alexander
Published: November 2023

El COVID-19 ha impactado múltiples dimensiones económicas y sociales de la población. Los gobiernos, en respuesta a la caída en los ingresos de los hogares y los subsecuentes impactos sobre la pobreza, han creado o fortalecido programas de transferencias monetarias. El presente artículo tiene como objetivo estudiar la incidencia de los ingresos provenientes de las ayudas institucionales sobre los niveles de pobreza monetaria en los hogares de Colombia. Metodoló­gicamente se estima un modelo econométrico tipo Logit para analizar la correlación entre las ayudas monetarias institucionales y la probabilidad de ser pobre antes y durante la pandemia. Los datos provienen de la Misión de Empalme de las Series de Empleo, Pobreza y Desigualdad (Mesep) para los años 2002, 2018, 2019 y 2021. Los resultados indican que el aumento de los niveles de pobreza durante la pandemia se dio fundamentalmente en el sector urbano. Las estimaciones econométricas sugieren que las ayudas externas recibidas por los hogares reducen la probabilidad de ser pobre, aunque este efecto marginal es decreciente en el tiempo.
Treatment of localized anterior toothwear with composite restorations at an increased occlusal vertical dimension
Authors: Durbar Ulpee R , Hemmings Ken W
Published: November 2023

Patients may present with localized anterior toothwear, complaining of poor appearance or sensitivity. or both. Restoration of these teeth continues to cause problems, especially if interocclusal space has been lost. Conventional treatment to satisfy the patient's aesthetic and functional demands is time consuming and requires careful maintenance. This paper describes the use of chairside composite resin restorations in the treatment of localized anterior toothwear. lnteroccusal space is provided by placing the restorations at an increased vertical dimension of occlusion. It enables the presenting complaint to be resolved while restoring structure, function and appearance.

CPD/Clinical Relevance: Localized anterior toothwear may be treated in suitable cases by placement of palatal composite restorations, with posterior tooth contact normally being re-established within 6 months.

Original article reproduced in full from: Darbar UR, Hemmings KW. Treatment of localized anterior toothwear with composite restorations at an increased occlusal vertical dimension. Dent Update 1997; 24: 72–75. (Please note that the figures have been reproduced from the original printed version.)
Extrinsic and intrinsic chemical factors relating to tooth wear
Authors: O'Toole Saoirse , Bartlett David
Published: November 2023

Human enamel is one of the strongest and hardest substances in the body. However, in the presence of repeated and regular exposure to acids, damage occurs at an increased rate of progression, potentially affecting aesthetics and reducing the restorability of the teeth. This article provides an update on the extrinsic and intrinsic chemical factors that can cause tooth wear. Updated information on gastro-oesophageal reflux, obstructive sleep apnoea, asthma and eating disorders are discussed. Bearing in mind the number of medical conditions that can impact on progression, our job as dentists is to inform the patient of the importance of prevention in other areas of their lives, such as diet and oral hygiene, to mitigate progression.

CPD/Clinical Relevance: Updated information on the chemical risk factors for erosive tooth wear progression is relevant for GDPs.
Full mouth restorative rehabilitation of the generalized worn dentition: a step-by-step approach to treatment
Authors: Feito Jose Suarez , Mehta Shamir B , Banerji Subir
Published: November 2023

In this article, full-mouth restorative rehabilitation of the generalized worn dentition is presented. In the authors' opinion, the steps to achieve a predictable functional and aesthetic outcome are proposed and illustrated using clinical case examples. The rationale for each step is outlined and the longer-term expectations, from the point of view of both the clinicians and patients are considered.

CPD/Clinical Relevance: Knowledge of a step-by-step approach to the full-mouth rehabilitation of the worn dentition is valuable for clinicians.
Multidisciplinary management of advanced complexity tooth wear cases: patient needs beyond the direct and indirect restorations dichotomy
Authors: Calvert Gareth , Keys William , Ahmed Khaled E
Published: November 2023

There is increased evidence supporting the different management modalities of tooth wear, be it direct or indirect resin composite through an additive approach, or ceramics through a subtractive one. However, there remains a cohort of patients with complex clinical case presentations that require careful assessment, formulation of a multidisciplinary treatment plan, and the delivery of a restorative-led systematic intervention involving additional oral surgery or orthodontic specialties. This case series presents the multidisciplinary management of advanced complexity tooth wear cases, with treatment needs extending beyond the scope of direct and indirect restorative management, through a systematic treatment planning approach.

CPD/Clinical Relevance: To highlight the potential multidisciplinary management options of tooth wear.
The ‘satisficing’ additive composite approach to bulimia
Authors: Kelleher Martin , Ayub Khawer
Published: November 2023

Bulimia (‘ox hunger’) is a serious, potentially dangerous, eating disorder that is often associated with anxiety about weight and body shape. People with bulimia ‘binge’, meaning that they eat large amounts of food, and then vomit afterwards to ‘purge themselves’ in order to get rid of those recently ingested calories. Frequent vomiting of the stomach hydrochloric acid and other ingested acids (pH 1–2) produces variable, but often catastrophic, erosion of the palatal aspects of the upper teeth in particular.

‘Satisficing’ is a word made from combining ‘sufficient’ and ‘satisfactory’. It means seeking an outcome that meets the essential requirements for it to be ‘sufficient to be satisfactory for that situation’.

These authors recommend pragmatic early additive direct resin composite bonding as being a ‘satisficing’ approach to help manage tooth surface loss in bulimic patients, and the article provides clinical examples of some dental problems caused by bulimia being solved in that way.

CPD/Clinical Relevance: This article addresses a number of controversial issues in the dental management of patients with bulimia nervosa (‘bulimia’).
Longevity and performance of materials used for the restorative management of tooth wear: a review
Authors: Lima Verônica P , Pereira-Cenci Tatiana , Mehta Shamir B , Banerji Subir , Loomans Bas AC
Published: November 2023

This article provides an overview of the available evidence on the performance, with particular consideration of the longevity of restorative materials used in the management of tooth wear. Different materials can be employed depending on whether a subtractive or additive strategy is used. Preference should be given to the latter to help preserve remaining tooth tissue. The use of both direct and indirect materials may yield acceptable survival results when considering data with at least 5 years of follow-up. Patients should be informed that because tooth wear is a continuous process, a certain level of maintenance of the restorations will be necessary and that this may impact on the success of the treatment.

CPD/Clinical Relevance: Conservative, adhesive strategies are suitable for the restorative management of tooth wear.
Latest clinical research
Authors: Greener Mark
Published: November 2023

The latest studies of interest to primary care clinicians rounded up by Mark Greener
The pharmacies helping older people stay ‘winter fit’
Authors: Heffernan Catherine
Published: November 2023

Catherine Heffernan looks at a new initiative aimed at pharmacies playing a fuller role in primary care
Domperidone
Authors: Rees Sharon
Published: November 2023

In this column, Sharon Rees aims to refresh knowledge and interest in some of the commonly used drugs in a series of tweets. This month she is talking about #domperidone
Prescribing in cancer care
Authors: Robertson Deborah
Published: November 2023

Deborah Robertson provides an overview of recently published articles that may be of interest to non-medical prescribers. Should you wish to look at any of the papers in more detail, a full reference is provided
Probiotics and antibiotics
Authors: Winter George
Published: November 2023

While promoting antibiotic stewardship, alternative antibiotic-free approaches to bacterial infections are being explored, including the use of probiotics, says George Winter
A–Z of prescribing for children
Authors: Davies Kate
Published: November 2023

This series focuses on aspects of prescribing for neonates, children and young people, from A–Z. Aspects of pharmacokinetics will be considered, alongside legal considerations, consent and medications in schools
Medication for hypertension management
Authors: Bostock Beverley
Published: November 2023

Hypertension is a major risk factor for cardiovascular disease, heart failure, vascular dementia and chronic kidney disease, and the management of hypertension combines both lifestyle and pharmacological interventions. Guidelines are available nationally and internationally to support these approaches to managing blood pressure and reducing cardiovascular risk. This article discusses the diagnosis and management of hypertension, along with the role of medication to lower blood pressure. Particular consideration is given to the place for different drug treatments based on their mode of action, specific indications and potential side effects. By the end of this article, readers should be able to review how different types of hypertension are diagnosed; compare national and international guidelines; consider the different types of medication most commonly used in hypertension; and evaluate the mode of action and how this influences indication for use and possible side effects.
Supporting children, young people and families with eczema
Authors: Lawton Sandra
Published: November 2023

Eczema is a complex disease to self-manage, between tackling the flares, following a regular maintenance regimen and avoiding triggers. It also has an impact on all aspects of life of infants, children, young people and their families, from self-esteem to relationships, education and social activities, mainly due to persistent itching and pain, sleep disturbance and emotional distress. Effective treatment of eczema demands good self-management which, if established early on, can lead to considerable improvements in quality of life and adherence to an agreed plan.
Surgical Treatment of Distal Radius Fractures Complicated by Concomitant Flexor Carpi Radialis Brevis: A Case Series and Surgical Techniques
Authors:   Department of Orthopaedics Surgery, Tone Chuo Hospital, Numasu-machi, Numata, Japan,, Hosokawa Takafumi , Tajika Tsuyoshi ,   Department of Rehabilitation, Gunma University Graduate School of Health Sciences, Maebashi, Japan,, Suto Morimichi ,   Department of Orthopaedics Surgery, Tone Chuo Hospital, Numasu-machi, Numata, Japan,, Chikuda Hirotaka ,   Department of Orthopaedics Surgery, Gunma University Graduate School of Medicine, Maebashi, Japan.
Published: November 2023

Introduction: The flexor carpi radialis brevis (FCRB) is a rare anatomical variation, with a reported prevalence ranging from 0.9% to 8.7%. Our previous report showed three cases of FCRB in distal radius fracture (DRF) and found that hypoplastic pronator quadratus (PQ) adjacent to the FCRB muscle made it difficult to cover a volar locking plate (VLP). As we subsequently experienced additional six FCRBs, we report on new findings and surgical tips. Case Report: VLP fixation was performed on DRF with FCRB in nine limbs of eight patients. The prevalence was 2.9% (9 of 310 limbs). Of the seven patients that underwent unilateral surgery, six were muscle type and one was tendon type. One patient who underwent bilateral surgery had a muscle type on the left and a tendon type on the right. In three muscle types, as the FCRB muscle belly was widely attached to the radial side of the radius and the radial side of the PQ was hypoplastic, postoperative covering of the plate by repair of the PQ was impossible. Then, in two of those cases, the PQ and FCRB were sutured and the plate was covered. FCRB muscle could be retracted to the radial side in all cases. One patient with a tendon type had a ruptured tendon, which was left unrepaired. All patients had no postoperative problems. Conclusion: In the muscle-type FCRB, the muscle should be retracted to the radial side for VLP fixation. The muscle belly might occupy the radial side of the radius, and the PQ might be hypoplastic and unrepairable. However, the plate can be covered by suturing the PQ and FCRB. Keywords: Flexor carpi radialis brevis, distal radius fracture, hypoplastic pronator quadratus.
Engineering Waveguide Nonlinear Effective Length via Low Index Thin Films
Authors: Ferrera Marcello , Jaffray Wallace , Ali Farhan , Stengel Sven , Guo Ziheng , Schulz Sebastian , Di Falco Andrea
Published: November 2023

Novel photonic nanowires were fabricated using low-index materials and tested in the near-infrared spectrum to assess their nonlinear optical properties. In this work, we argue the need to redefine the standard nonlinear figure of merit in terms of nonlinear phase shift and optical transmission for a given propagation distance. According to this new metric, our devices largely outperform all established platforms for devices with a linear footprint in the range of 50 to 500 μm, which is demonstrated to be an outstanding technological gap. For 85 fs pulses, with carrier wavelength at 1480nm and sub-μW power levels, a spectral broadening exceeding 80% of the initial bandwidth was recorded over a propagation length of just 50 μm. Leveraging on CMOS-compatible processes and well-established materials such as silicon, silica, and indium tin oxide, our devices bring great promise for developing alternative all-optical devices with unparalleled nonlinear performances within the aforementioned range.
How does extreme weather impact the climate change discourse? Insights from the Twitter discussion on hurricanes
Authors: Torricelli Maddalena , Falkenberg Max , Galeazzi Alessandro , Zollo Fabiana , Quattrociocchi Walter , Baronchelli Andrea
Published: November 2023

The public understanding of climate change plays a critical role in translating climate science into climate action. In the public discourse, climate impacts are often discussed in the context of extreme weather events. Here, we analyse 65 million Twitter posts and 240 thousand news media articles related to 18 major hurricanes from 2010 to 2022 to clarify how hurricanes impact the public discussion around climate change. First, we analyse news content and show that climate change is the most prominent non hurricane-specific topic discussed by the news media in relation to hurricanes. Second, we perform a comparative analysis between reliable and questionable news media outlets, finding that unreliable outlets frequently refer to climate-related conspiracies and preferentially use the term “global warming” over “climate change”. Finally, using geolocated data, we show that accounts in regions affected by hurricanes discuss climate change at a significantly higher rate than accounts in unaffected areas, with references to climate change increasing by, on average, 80% after impact, and up to 200% for the largest hurricanes. Our findings demonstrate how hurricanes have a key impact on the public awareness of climate change.
Differences in the health-related quality of life in patients with asthma living in urban and rural areas in the Amur Region of Russian Federation
Authors: Perelman Natalia L. , Kolosov Victor P.
Published: November 2023

Background

Asthma usually arises from an interaction between host and environmental factors. Growing attention has been paid to a place of residence as a factor shaping health-related quality of life (QoL). This study investigated the rural-urban disparity in QoL among adult asthma patients in the Amur region of Russian Federation.

Materials and methods

This cross-sectional study included 351 randomly selected adults with asthma. We analyzed QoL (SF-36 and AQLQ scores), asthma control (ACT), and anxiety and depression (HADS) depending on the place of residence (urban vs. rural).

Results

The scale “Role Emotional” (RE) of SF-36 was significantly lower in patients from rural areas compared to urban residents (59.3±3.1 vs. 70.4±2.3 points; p = 0.0042). In the urban group, the correlation analysis demonstrated a clear influence of RE on patients’ own assessment of their physical functioning (PF, r = 0.53; p<0.0001). Both groups demonstrated low “Social Functioning” (SF). In the group of urban residents, correlation analysis revealed the presence of positive correlations of SF-36 domains reflecting physical (PF, RP, BP) and social functioning (SF, VT) with most scales of both QoL questionnaires. The domains of the emotional sphere (RE and MH) positively correlated with all scales of both QoL questionnaires among urban residents. In the group of rural residents, a comparative analysis showed the absence of significant correlations between more of the QoL scales. Although Asthma Control Test did not differ between groups, we noted a significantly higher need for β2-agonists in rural areas compared to urban areas (4.2±0.6 vs. 2.7±0.3 inh/day, respectively; p = 0.0221). The frequency of urban residents with a clinically significant level of anxiety (56 persons, or 25.2%) turned out to be lower compared to rural residents (45 persons, or 34.8%; χ2 = 34.08; p<0.001).

Conclusion

The burden of asthma introduces a greater imbalance in the health-related QoL of rural residents compared to urban residents in the Amur region of the Russian Federation. The absence of interrelationships of some QoL domains in rural residents suggested a disunity of the physical, psychological and social aspects of life. The rural residents suppress physical discomfort by the more frequent use of short bronchodilators. They often showed emotional instability with a predominance of anxiety, which affected the decrease in QoL in the psycho-emotional sphere.
Sclerochronological characteristics of Orbicella faveolata in Cayo Arenas, a remote coral reef from the Gulf of Mexico
Authors: Sánchez-Pelcastre D. Wendoline , Tortolero-Langarica J. J. Adolfo , Alvarez-Filip Lorenzo , Cruz-Ortega Israel , Carricart-Ganivet Juan P.
Published: November 2023

During coral calcification in massive scleractinian corals, a double annual banding of different densities (high- and low-density) is formed in their skeletons, which can provide a retrospective record of growth and the influence of environmental conditions on the coral’s lifespan. Evidence indicates that during the last decades, the reduction in coral calcification rate is attributed to the combination of global stress factors such as Sea Surface Temperature (SST) and local anthropic stressors. Yet, coral growth trajectories can vary between regions and coral species, where remote locations of coral reefs can act as natural laboratories, as they are far from the harmful effects of direct anthropogenic stressors. The present study reports historical chronology over a 24-year period (1992–2016) of coral extension rate (cm yr-1), skeletal density (g cm-3), and calcification rate (g cm-2 yr-1) of the reef-building coral Orbicella faveolata at the remote reef Cayo Arenas, Campeche Bank, in the south-eastern Gulf of Mexico. The relationships between the three sclerochronological features show that O. faveolata uses its calcification resources to build denser skeletons. Chronological trends indicate that coral extension increased, skeletal density and calcification rate decreased (33% calcification rate) over time. The results reveal that despite the remoteness of the locality the maximum SST has been increased, and the coral calcification rate decreased over time. If the temperature continues to rise, there is a conceivable risk of experiencing a decline in reef-building coral species. This scenario, in turn, could pose a significant threat, endangering not only the framework of coral reefs but also their ecological functionality, even within remote Atlantic reef ecosystems.
Regulation of host gene expression by J paramyxovirus
Authors: Wrobel Elizabeth R. , Jackson Jared , Abraham Mathew , He Biao
Published: November 2023

Paramyxoviruses are negative-sense, single-stranded RNA viruses that are associated with numerous diseases in humans and animals. J paramyxovirus (JPV) was first isolated from moribund mice (Mus musculus) with hemorrhagic lung lesions in Australia in 1972. In 2016, JPV was classified into the newly established genus Jeilongvirus. Novel jeilongviruses are being discovered worldwide in wildlife populations. However, the effects of jeilongvirus infection on host gene expression remains uncharacterized. To address this, cellular RNA from JPV-infected mouse fibroblasts was collected at 2, 4, 8, 12, 16, 24, and 48 hours post-infection (hpi) and were sequenced using single-end 75 base pairs (SE75) sequencing chemistry on an Illumina NextSeq platform. Differentially expressed genes (DEGs) between the virus-infected replicates and mock replicates at each timepoint were identified using the Tophat2-Cufflinks-Cuffdiff protocol. At 2 hpi, 11 DEGs were identified in JPV-infected cells, while 1,837 DEGs were detected at 48 hpi. A GO analysis determined that the genes at the earlier timepoints were involved in interferon responses, while there was a shift towards genes that are involved in antigen processing and presentation processes at the later timepoints. At 48 hpi, a KEGG analysis revealed that many of the DEGs detected were involved in pathways that are important for immune responses. qRT-PCR verified that Rtp4, Ifit3, Mx2, and Stat2 were all upregulated during JPV infection, while G0s2 was downregulated. After JPV infection, the expression of inflammatory and antiviral factors in mouse fibroblasts changes significantly. This study provides crucial insight into the different arms of host immunity that mediate Jeilongvirus infection. Understanding the pathogenic mechanisms of Jeilongvirus will lead to better strategies for the prevention and control of potential diseases that may arise from this group of viruses.
Lake eutrophication prediction based on improved MIMO-DD-3Q Learning
Authors: Wang Li , Ning Chaoran , Wang Xiaoyi , Xu Jiping , Zhao Zhiyao , Yu Jiabin , Zhang Huiyan , Sun Qian , Bai Yuting , Jin Xuebo , Tang Qianhui
Published: November 2023

As for the problem that the traditional single depth prediction model has poor strain capacity to the prediction results of time series data when predicting lake eutrophication, this study takes the multi-factor water quality data affecting lake eutrophication as the main research object. A deep reinforcement learning model is proposed, which can realize the mutual conversion of water quality data prediction models at different times, select the optimal prediction strategy of lake eutrophication at the current time according to its own continuous learning, and improve the reinforcement learning algorithm. Firstly, the greedy factor, the fixed parameter of Agent learning training in reinforcement learning, is introduced into an arctangent function and the mean value reward factor is defined. On this basis, three Q estimates are introduced, and the weight parameters are obtained by calculating the realistic value of Q, taking the average value and the minimum value to update the final Q table, so as to get an Improved MIMO-DD-3Q Learning model. The preliminary prediction results of lake eutrophication are obtained, and the errors obtained are used as the secondary input to continue updating the Q table to build the final Improved MIMO-DD-3Q Learning model, so as to achieve the final prediction of water eutrophication. In this study, multi-factor water quality data of Yongding River in Beijing were selected from 0:00 on July 26, 2021 to 0:00 on September 5, 2021. Firstly, data smoothing and principal component analysis were carried out to confirm that there was a certain correlation between all factors in the occurrence of lake eutrophication. Then, the Improved MIMO-DD-3Q Learning prediction model was used for experimental verification. The results show that the Improved MIMO-DD-3Q Learning model has a good effect in the field of lake eutrophication prediction.
A long-term retrospective cohort-based risk-benefit analysis of augmenting total cumulative I-131 activity to 37GBq in differentiated thyroid cancer patients with skeletal metastases
Authors: Kanankulam Velliangiri Sivasankar , Ballal Sanjana , Prasad Yadhav Madhav , Tripathi Madhavi , Satapathy Swayamjeet , Bal Chandrasekhar
Published: November 2023

Objective

Skeletal metastases in differentiated thyroid cancer (DTC) patients are associated with poor prognosis. The objective was to determine the maximum I-131 cumulative activity that could be safely administered without compromising efficacy. The secondary objective was to identify other prognostic factors affecting survival outcomes.

Materials and methods

This was a retrospective cohort study done at a tertiary-care institution comprising of data from January 1990-June 2020. 489 DTC patients having skeletal metastases with ≥12 months follow-up were included. Ninety-six percent of patients had thyroidectomy followed by radioiodine therapy for skeletal metastases. All patients were on oral suppressive levothyroxine tablets. External beam radiotherapy (EBRT) and oral tyrosine kinase inhibitors were used whenever indicated. The main outcome measures were overall survival (OS), progression-free survival (PFS), and adverse-events.

Results

There were 347 (71%) females and 324 (66%) had follicular carcinoma thyroid. Median follow-up was 78 (interquartile range, IQR: 37–153) months. 333 patients (68%) received ≤37GBq I-131 cumulative activity (group 1) and 156 patients (32%) received >37GBq cumulative RAI activity (group 2). Overall median OS and PFS were 74 (95% confidence interval (CI): 62.2–85.8) and 48 (95%CI: 40.5–55.4) months, respectively. The 5-, 10-, 15- and 20-year estimated overall survival probabilities were 55.7%, 28.4%, 14% and 8.3%, respectively. On multivariate analysis, age(<55years) (p<0.001), female gender(p = 0.01), cumulative I-131 activity >37GBq (p<0.001) and EBRT(p = 0.001) were favourably associated with OS; no factors were significantly associated with PFS. The median OS for groups 1 & 2 were 51 versus 90 months (p<0.001) & median PFS for groups 1 & 2 were 45 versus 53 months respectively (p = 0.9). However, cumulative activity >37GBq resulted in more adverse events (2.4%), particularly bone marrow suppression (3.5%).

Conclusion

For better survival outcomes, cumulative I-131 activity upto 37GBq could be administered with acceptable toxicity to DTC patients with skeletal metastases.
Notas para o conhecimento da cerâmica medieval no Alto Paiva. O contributo do sítio de Carvalhais (Vila Nova de Paiva, Viseu)
Authors: Afonso Vieira Marina , Temudo Susana
Published: November 2023

Apresenta‑se o estudo do espólio cerâmico proveniente de uma escavação de minimização de impacte, realizada em 2015/2016, no sítio arqueológico de Carvalhais. Apesar de as estruturas exumadas não terem dado informação relevante, a pequena coleção cerâmica reúne condições para fornecer dados a ter em conta na caracterização da cultura material da alta Idade Média. Do breve estudo cerâmico efetuado releva‑se que existe alguma homogeneidade no conjunto, na sua maioria as suas pastas são pouco depuradas, contêm grande número de elementos não plásticos e poderão corresponder a pastas graníticas locais. Através dos vasos estudados percebe‑se que o repertório formal é reduzido, predominando os potes/panelas, alguidares e jarros. Partindo das características formais, tecnológicas e estilísticas das cerâmicas, sem esquecer a análise macroscópica das pastas e superfícies, procurou‑se contrastar a coleção com contextos alto medievos bem conhecidos e com datações absolutas.
José Luís Madeira
Authors: Alarcão Jorge de , D’Encarnação José
Published: November 2023

José Luís Antunes Madeira, que serviu o Instituto de Arqueologia da Faculdade de Letras de Coimbra durante 30 anos e se aposentou em fevereiro último, merece uma homenagem nas páginas desta revista que ao longo de três décadas lhe ficou devendo o arranjo gráfico e muitos dos desenhos com que vários dos seus números foram ilustrados. A ele também se fica devendo, e desde o primeiro número, a montagem do Ficheiro Epigráfico.
Sobre os Callaeci e o seu epónimo: algumas considerações
Authors: S. P. Silva António Manuel
Published: November 2023

Tomando como ponto de partida o trabalho publicado no anterior número de Conimbriga (Fernández Calo, “Os Callaeci e a questão eponímica”), discutem-se diversos aspetos historiográficos, com base, essencialmente, nas fontes literárias clássicas e na epigrafia latina, acerca da localização, tanto do núcleo urbano de Cale, mencionado pela primeira vez no “Itinerário de Antonino”, como do populus/ciuitas dos Callaeci, que a tradição literária identifica como a primeira comunidade indígena situada a norte do rio Douro que afrontou o cônsul romano Decimus Iunius Brutus quando este fez uma incursão militar ao noroeste da península em 138-137 a.C. O triunfo da missão fez com que Brutus adotasse o cognome honorífico Calaicus, celebrado em vários monumentos de Roma. Conclui-se que, não obstante o estudo de Fernández Calo ter o propósito de renovar a discussão sobre um tema fundamental da história antiga do Noroeste, a falta de novas fontes, designadamente epigráficas, não permite que se alcancem ganhos significativos na interpretação dos dados disponíveis.
New evidence of roman governors and officers on glandes inscriptae from Republican Hispania
Authors: Rothenhoefer Peter , Moralejo Ordax Javier
Published: November 2023

Four glandes inscriptae from the Iberian Peninsula are presented in this paper. For two of them a connection to the Republican governors C. Flaminius and L. Mummius is proposed, and therefore a date in the 2nd century BC. A third slingshot bullet was most likely cast at the beginning of the governorship of the proconsul C. Valerius Flaccus, c. 92/91 BC. On the fourth specimen two names are inscribed, Afranius and Messalla, presumably two military leaders; it is carefully suggested that they could have been active during the Sertorian War. The communis opinio regarding the use of glandes inscriptae on the Iberian Peninsula must be modified: rather than being a phenomenon of the 1st century BC, peculiar to the Sertorian War (82‑72 BC) and the confrontation between Caesar and the Pompeian faction (48‑45 BC), they can now be traced back as far as the early 2nd century BC.
O contributo de métodos não invasivos na deteção do perímetro das cidades romanas provinciais: o caso do municipium de Balsa (Tavira, Portugal)
Authors: Rondán Isabel , Bernardes João Pedro , Lagóstena Barrios Lázaro , Candeias Celso
Published: November 2023

Um dos problemas que se coloca na investigação das cidades romanas provinciais é a determinação do seu perímetro a partir do registo de superfície. Com efeito, nem sempre é fácil a partir de dados de prospeção distinguir o pomerium da cidade, das construções que se edificaram na sua envolvente como acontece com o municipium flávio de Balsa. A cidade romana de Balsa, situada no sul da Lusitânia, tem frequentemente sido referida como uma importante e extensa cidade, cujos vestígios foram em grande parte destruídos por trabalhos agrícolas. No entanto, apesar de tentativas de reconstituição desta cidade portuária, as escavações realizadasforam muito limitadas e pontuais e nunca houve no terreno uma investigação sistemática. Com o projeto, Balsa, Searching the origins of Algarve, procurou‑se, através de intensas prospeções geofísicas não invasivas e sondagens pontuais, esclarecer a dimensão da malha urbana e grau de preservação da antiga urbs, de que se conhece um extenso e rico espólio oriundo das suas necrópoles e uma interessante epigrafia honorífica e funerária. Osresultados obtidos têm permitido verificar que se trata de uma cidade muito mais pequena do que se pensava, mas com um importante conjunto de villae em seu torno que foi frequentemente confundido com a extensão da sua malha urbana.
El fotografo de Minamata (2020): de la fotografía humanista a los defectos congénitos por metilmercurio en la asignatura de embriología humana
Authors: Richard Enrique
Published: November 2023

El fotógrafo de Minamata (2020) de Andrew Levitas es una película importante para comprender cómo la contaminación del medio ambiente puede tener una gran influencia en la salud humana. Muestra cómo la contaminación afecta a las comunidades, cómo éstas se resisten a aceptar la responsabilidad de la empresa responsable y cómo la comunidad y los medios de comunicación pueden trabajar juntos para abordar estas cuestiones y tomar medidas para prevenir y tratar estos problemas. En la docencia universitaria de Ciencias de la Salud se constituye en un recurso pedagógico importante para ilustrar y concientizar sobre la problemática toxicológica del metilmercurio en la salud humana y especialmente durante la gestación promoviendo el desarrollo de diversos defectos congénitos. El visionado del film por otro lado estimula el pensamiento crítico, divergente, analítico, reflexivo, emocional y el aprendizaje significativo, al tiempo que permite integrar conocimientos de las asignaturas que cursan y cultura general en una experiencia inmersiva. Asimismo, permite integrar el arte del filme y la fotografía de W. Eugene Smith como una transversal educativa que contribuye al acervo de cultura general del estudiante.
Paracelso y la medicina del Renacimiento en el cine
Authors: D’Ottavio-Callegari María Silvia , D’Ottavio-Cattani Alberto Enrique , D’Ottavio-Callegari María Eugenia
Published: November 2023

La breve, azarosa y fructífera vida de Paracelso, médico del siglo XVI, motivó en 1943, aproximadamente 400 años después de su muerte, a un film homenaje alemán que rescató un fragmento de su existencia. El rodaje y estreno se realizó en plena segunda guerra mundial y fue controlado rigurosamente por el nazismo. Esto produjo determinadas polémicas, aún vigentes, relacionadas con su director. Este trabajo intenta dar cuenta de ambos hechos.
Unlocking Success: Transforming Primary School Experience with Neuro-Linguistic Programming-Based Interventions in Lebanon
Authors: Tarhini Sarah , Manana Marwa , Ghanem Diana , Abbas Nour , Ismaiil Lina , Awada Sanaa , Hatem Georges
Published: November 2023

Introduction: Neuro-linguistic programming (NLP) is a method surrounded by controversy, aiming to modify how individuals respond to stimuli, influencing their environment and personal behaviors. Applied across diverse domains, including education, NLP seeks to assist students in developing their skills and addressing academic, social, and behavioral challenges.

Objective: This study aims to evaluate the impact of implementing NLP on mitigating school-related triggers among primary school children in Lebanon.

Methods: 128 participants aged 6 to 11 were involved in a comprehensive four-month research investigation. The T-test was employed to analyze pre- and post-NLP intervention outcomes, and correlations between various features and total scores within each group were examined.

Results: The general characteristics of the control and case groups were comparable, revealing no statistically significant differences. The NLP intervention reduced academic trigger scores from 3.91 to 3.54 and behavioral trigger scores from 4.48 to 3.9, particularly among children aged 9 years and above. Notably, social and environmental trigger scores significantly decreased among all children after NLP treatment (p<0.001 and p=0.007, respectively). Negative correlations were observed between trigger scores and age (-0.408, -0.343, -0.448 for academic, behavioral, and social scores, respectively; p<0.001), signifying a decline in trigger scores with increasing age. However, NLP was more effective in males than females (p<0.05). The most pronounced correlations were identified between students' age and grade (-0.448 and -0.516, respectively) and social trigger scores. In contrast, minimal correlations were established between parents' marital status, level of education, economic situation, working status of parents, and the total number of children with any trigger scores. Students with divorced or separated parents exhibited significantly higher academic trigger scores [B=1.43 (0.29-2.55); p=0.014]. Additionally, children living with their fathers experienced a reduction in social trigger scores (B= -1.05 [-1.93- -0.10]; p=0.030).

Conclusion: NLP strategies have effectively alleviated various dimensions of triggers among learners.
Die deutsch-französischen Beziehungen der Ära Adenauer - de Gaulle 1958-63: Ein Drama in fünf Akten?
Authors: Riess Victoria
Published: November 2023

Seit 1000 Jahren besteht die Geschichte Deutschlands und Frankreichs, die 843 n. Chr. aus dem karolingischen Kaiserreich Karls des Großen hervorgingen (Vgl. Zeller 1954, S. 1), aus einem unablässigen Nebeneinander, Miteinander und Gegeneinander. Nach der These von Schwarz unterteilt sich das „endlose Drama“ (Schwarz 1993, S. 93) der deutsch-französischen Beziehungen in zwei große Akte. Aus diesem „zweite[n] Akt“ (Schwarz 1993, S. 67) hebt sich jedoch deutlich die Ära Adenauer - de Gaulle (1958-63) hervor, denn unter General Charles de Gaulle wandelte sich der Charakter der Beziehungen ab 1958 grundlegend. Daher ist in Anlehnung an die These von Schwarz, die deutsch-französischen Beziehungen als ein „endlose[s] Drama“ in „zwei [...] Akte[n]“ (Schwarz 1993, S. 93) zu verstehen, im Folgenden die These zu überprüfen, ob sich die deutsch-französischen Beziehungen in der Ära Adenauer - de Gaulle (1958-63) als ein klassisches Drama in fünf Akten begreifen lassen. Zu diesem Zweck verfolgt die vorliegende Arbeit das Ziel einer historischen Analyse der Beziehungen in der Ära Adenauer - de Gaulle unter Verwendung literaturtheoretischer Termini, wie Drama, Akt, etc. Im Folgenden werden diese dramentheoretischen Elemente mit den deutsch-französischen Beziehungen verglichen, wobei die Ära Adenauer - de Gaulle – festgelegt auf Juni 1958- Oktober 1963 durch den Amtsantritt de Gaulles beziehungsweise Amtsrücktritt Adenauers – hierfür besonders geeignet ist, da die grundsätzliche Zweiphasigkeit eines klassischen Dramas (Vgl. Greiner et al. 1982, S. 161) fast natürlicherweise gegeben scheint.
Fascismo en Colombia
Authors: Navia Angela
Published: November 2023

El presente escrito se propone reflexionar sobre la existencia del fascismo en Colombia. El uso del concepto es motivo de debate en sectores académicos, sociales y políticos. Por un lado, se habla de la impertinencia de su uso al caer en una exageración o anacronismo; por otro lado, se opta por términos como autoritarismo o populismo. Por eso nos preguntamos: ¿es válido hablar de fascismo en Colombia? Para dar respuesta, el escrito se compone de dos partes. En la primera se reflexiona sobre algunas características del fascismo; se lo hace a manera de tesis que sirven para el análisis y la discusión. Desde estas premisas, en la segunda parte se posiciona el contexto de Colombia. Se hace énfasis en dos elementos: la militarización y el anticomunismo como forma de construcción de enemigo interno. La reflexión concluye que sí se han gestado y se mantienen prácticas fascistas en Colombia; en consecuencia, es viable y necesario el uso del concepto.
Corticotropin-producing pheochromocytoma in multiple endocrine neoplasia type 1
Authors: Rebrova D. V. , Grigorova S. I. , Vorokhobina N. V. , Zgoda E. A. , Novokshonov K. Yu. , Feofanova S. G. , Rusakov V. F. , Krasnov L. M. , Fedorov E. A. , Chinchuk I. K. , Shikhmagomedov Sh. Sh. , Pushkaruk A. A. , Sleptsov I. V.
Published: November 2023

A clinical case of a man 66 y.o. who was diagnosed with hormone-inactive pituitary macroadenoma complicated by corneal erosion and partial atrophy of the optic nerve of the left eye due to exophthalmos. The increase in prolactin level was regarded due to a «stalk-effect». The patient underwent a transnasal pituitary adenomectomy with subsequent regression of symptoms. After 4 years, against the background of a new coronavirus infection, increasing general weakness, headaches, a crisis increase in blood pressure and tachycardia attacks appeared. Computed tomography (CT) accidentally revealed an adrenal incidentaloma, in laboratory tests — hypercortisolism, elevated ACTH levels, hypokalemia, hyperglycemia, increased levels of metanephrine and normetanephrine. The patient developed acute steroid psychosis, after which an adrenalectomy with a tumor was performed, a pheochromocytoma was histologically confirmed. After surgery, there was a regression of symptoms, the development of adrenal insufficiency with reduced levels of ACTH and cortisol. Upon further examination, a polynodose euthyroid goiter was established, the biopsy of the nodes — Hashimoto’s thyroiditis (Bethesda II). Meanwhile, primary hyperparathyroidism was detected. According to ultrasound, scintigraphy with Ts99m-Technetril and CT revealed an increase of left parathyroid gland. A bilateral revision of the neck, removal of the right upper and left upper parathyroid adenomas were performed. In the postoperative period, the levels of calcium and parathyroid hormone were normalized. Given the presence of a combination of multiple tumors of the endocrine system (primary hyperparathyroidism, corticotropin-producing pheochromocytoma, hormone-inactive pituitary macroadenoma, polynodose euthyroid goiter), the MEN1 syndrome was clinically established. The study of 2 and 10 exons of the MEN1 gene revealed no mutations, which does not exclude the presence of a hereditary syndrome. The patient continues observation. In the available literature in Russian and English languages the case of ACTH pheochromocytoma as part of the MEN type 1 syndrome have not been found. Therefore, we consider the presented case to be the first one.