bluuebunny/crossref_metadata_2025 huggingface dataset:
The Biological and Cultural Grounds for Ethics: Hans Jonas and Francisco Ayala
Authors: Quesada-Rodríguez Francisco
Published: July 2022

Regarding the epistemological borderlines between science and philosophy, this article approaches the human mind and ethics from biological and philosophical theories. For this purpose, the Darwinian theory of evolution by natural selection provides a scientific foundation to understand the human mind and ethics. However, not only Charles Darwin has studied mental faculties and ethics, this is also a topic researched by eminent contemporary paleontologists and biologists. Prior to modern biology, going back to Greek philosophy, philosophers have traditionally studied the human mind and ethics, separating human beings and the rest of nature ontologically. Following modern biology, the philosopher Hans Jonas has developed a philosophical biology from the perspective of hermeneutical phenomenology to understand life. With the help of his hermeneutical phenomenology, Jonas has presented an ontological theory of organism-metabolism to understand the phenomenon of life from simple living beings to the human mind in relation to nature, based on the body. Recently, the evolutionary biologist Francisco Ayala has proposed a coherent scientific and philosophical theory about biological and cultural roots for ethics, considering the evolution of human mental and intellectual capacities and the three conditions for ethical behavior as a part of human intellectual capacity, which scientifically complements and informs Hans Jonas’s philosophical biology and ethics of responsibility.
On Living Beings: Biological and Philosophical Aspects
Authors: Jordana Butticaz Rafael , Sánchez-Palencia Martí Ángel
Published: July 2022

This is an interdisciplinary work (biology-philosophy) product of reflection on the challenges today presented by a biological vision of the world regarding questions, concepts and notions of cosmology (Philosophy of Nature). Based on and in dialogue with the current state of biological research, this work deals with certain cosmological problems such as that between the living and the inert, the traditional division between the soul or the vital vegetative principle, sensitive or intellective; the problem of individuation and the concept of species, among others; the solution found within classical philosophy in this paper takes into account the latest discoveries findings of modern biology.
Naturaleza humana y transhumanismo
Authors: Postigo Solana Elena
Published: July 2022

Hemos recogido hasta aquí algunas de las notas características de la naturaleza humana: su inteligencia, su dimensión social, histórica, biográfica y cultural. Se podrían señalar otros rasgos comunes a todo ser humano como la libertad, la dignidad, la finitud y la vulnerabilidad. No teníamos la pretensión de ser exhaustivos sino de apuntar una tercera vía en la compresión de la naturaleza humana (entre el biologicismo y el socioculturalismo). Es posible una tercera vía, que recoge algunos elementos desde el pensamiento clásico a nuestros días, pasando por autores contemporáneos como Zubiri, personalistas y demás, y hacer una propuesta de naturaleza humana como aquello que hace al humano ser quien es y no otro animal cualquiera. La especificidad de lo humano es innegable, y su irreductibilidad a materia queda en el horizonte como un punto de fuga, donde quizá haya que invocar la dimensión del enigma o el misterio, con palabras del Profesor Miguel García-Baró, y recuperar la verticalidad del ser humano, el horizonte último de compresión acerca de quién es, de su sentido y significado. «La ciencia es cumulativa, la sabiduría no», afirmó Jérôme Lejeune. La ciencia progresa exponencialmente, a una velocidad acelerada, el transhumanismo es prueba de ello; por contrario, la sabiduría no. El desarrollo de la razón técnico-instrumental está siendo muy rápido y acelerado; la razón sapiencial, en cambio, procede lentamente, sin capacidad de analizar con calma y detalle todo lo que implican estos cambios. Se nos exige una mayor reflexión acerca de quiénes somos y hacia dónde vamos como especie. El transhumanismo y el posthumanismo se plantean la cuestión de la utilidad, pero no aquellas del significado y el sentido último, o primero, de la existencia humana.
Robótica y cyborgs
Authors: Lumbreras Sancho Sara
Published: July 2022

Uno de los principales retos del transhumanismo lo encontramos en su antropología. Nos encontramos ante un reduccionismo en el que el cuerpo aparece despojado de su dignidad y el espíritu no existe. El ejemplo que más me llama la atención de esto es el de la endogénesis: no se valora el hecho de que el ser humano sea gestado dentro del vientre de otro ser humano; para ellos sería preferible tener una máquina que pudiese hacer la misma misión, en lugar de que el embarazo sea un acto de amor que tiene impacto en toda la vida de la persona. Creo que este es el mayor obstáculo en el que nos encontraremos al valorar el transhumanismo, y es especialmente importante: la persona es un edificio de múltiples dimensiones (física, psíquica, espiritual...) inextricablemente ligadas. Es necesario reconocer la dignidad de nuestro cuerpo, que va más allá de ser sustrato material de nuestra consciencia. El cuerpo forma parte de nuestra naturaleza, en la que cuerpo, emoción, pensamiento y espíritu son dimensiones que están íntimamente ligadas. No podemos renunciar a nuestro cuerpo. Además, me gustaría proponer que dentro del cuerpo existen portales ante la trascendencia. no es lo mismo ser que parecer. Muchos defienden que pronto tendremos robots que estarán dotados de consciencia. Que podrán pasar el test de Turing. Además, la Inteligencia Artificial (IA) permite generar mensajes de manera sintética. En algunos casos, estos mensajes son relativamente simples, pero en otros casos, como los chatbots (robots diseñados para conversar), resultan muy interesantes. Algunos autores estiman que, dentro de poco, estos chatbots podrían llegar a pasar el test de Turing (es decir, lograr convencer a un interlocutor humano de que está conversando con otra persona). Una vez tengamos máquinas que pasen el test de Turing, ¿podremos decir que son conscientes? ¿Es lo mismo una máquina que pase el Test de Turing que una máquina consciente? Para algunos, la respuesta es «es indiferente». Yo digo que no, que no es lo mismo.
La teoría de Leibniz acerca del origen de los números y el Misterio de la Trinidad
Authors: Amunátegui Godofredo Iommi
Published: July 2022

Entre los años 1678 y 1685 Leibniz compuso dos tratados – Circa Geometrica Generalia (C.G.G.) y Notationes Generales (N.G.) – en los cuales expone una críptica teoría del origen de los números enteros positivos estrechamente vinculada al Misterio de la Trinidad. Este trabajo propone una interpretación de las ideas matemáticas del filósofo mediante el concepto de determinatio. Tal hipótesis se utiliza para esclarecer el sentido teológico de la proposición leibniziana.
Wohin mit den Ansiedlungen, wenn die Flächen ausgehen?
Authors: Iwer Nicole , Gerber Markus
Published: July 2022

Due to increasing density-dependent competitions in land use, it is difficult to plan new industrial areas, especially for factories and businesses with a need for large-scaled sites. Economic interest groups demand to plan new industrial areas to keep the region in a competitive position. At the same time, many citizens and local politicians are concerned about new specific land use areas for industries. To locate suitable industrial sites in the catchment area of municipalities with land shortage and a high demand for space and to involve regional stakeholders into the planning process, new regional planning tools are required. The case study about the “Regionale Kooperationsstandorte” planning tool in this paper shows which additional values and challenges the recipients of the plan expect from the new planning approach. Apparently, the new regional planning tool is generally accepted by most of the stakeholders in the Ruhr Metropolis. But specific regulations and particular sites are highly controversial, due to diverging interests of different stakeholders and municipalities or due to changing circumstances, so that it is not possible to reach a consensus on all issues.
Effect of Combination Songga-Wood-Stem (Strychnos ligustrina Blume) and Antimalaria-ACT on IL-10 Production of Malaria
Authors: Djamiatun Kis - , Wirman Rahmi - , Wijayahadi Noor -
Published: July 2022

Malaria is one of the deadliest infectious diseases in the world. Artemisinin-Based-Combination-Therapy (ACT) an antimalaria recommended by WHO, is starting to experience resistance in Asia. Meanwhile the natural-product-immunoprotective and antimalaria-effect may benefice for malaria. Objective of this study was to determine the effect of combination of ethanolic-extract from Songga-wood-stem (EESWS) and ACT on IL-10, a protective-cytokine against malaria-immunopathology. This experimental-study used post-test-only-randomized-controlled-group-design. The thirty-Swiss-webster-mice were grouped into 5 groups. The one-group of healthy-mice (K1), and the four-groups infected with Plasmodium berghei ANKA (PbA) which were untreated-K2-group, ACT-treated-K3-group, EESWS-treated-P1-group, and EESWS-ACT-combination-treated-P2-group. IL-10-level of stimulated-splenocytes-culture was examined by ELISA-method. Data-analysis-used was One-Way-Anova-Welch-test and Post-hoc Games-Howell. P1 and P2-groups had higher IL-10-levels than K1 (p=0.038). Groups of P1 and P2 showed lower IL-10-levels than K3 (p=0.001). IL-10-level of P2-group was not different than P1 (p=0.135). The conclusion is the EEWS or EESWS-ACT-combination-therapy restrains the increase-splenic-IL-10-production above normal value in the healing phase of malaria infection.
The effect of fibre intervention on serum and faecal short-chain fatty acids in human with overweight or obesity: a systematic review of human intervention studies
Authors: Amalia Rinta , Noer Etika R , Muniroh Muflihatul , Afifah Diana N , Kumoro Andri C , Pramono Adriyan
Published: July 2022

Overweight/ obesity is associated with cardiovascular diseases, which both contribute to the severity of coronavirus disease 2019 (COVID-19). Nutritional interventions focusing on dietary fibre and prebiotics interventions have been implemented. Fibre has been suggested to modulate gut-derived metabolites short-chain fatty acid (SCFA). We conducted a systematic review on fibre (including prebiotics) interventions to depict its effect on SCFA from faecal and blood using standard methodologies. PubMed, Cochrane, Embase, CINAHL, and Scopus databases were systematically searched to yield peer-reviewed articles published until 31 December 2021. We included 17 articles describing fibre (including prebiotics) intervention in adult individuals with overweight/obesity. These interventions were broadly described into 3 groups: (i) fibre type food items (n = 8); (ii) fibre supplementations (i.e. prebiotics) (n = 8); (iii) prebiotic supplementation combined with CRD (n = 1). Fibre type food items intervention mostly affected the changes of acetate in faecal, whilst propionate mostly changed in the blood. Interestingly, intervention with fibre supplementation affects more the increase of faecal and blood acetate. Furthermore, fibre intervention might have an impact on the gut microbiota. Nevertheless, more well-controlled human studies are needed, with a more personalized approach.
An analysis of International Baccalaureate – English Language Curriculum for Middle Year Program
Authors: Maryono Geby Devtiana , Emilia Emi
Published: July 2022

The IB Curriculum, which was initially founded in Switzerland, is used globally. Many schools in Indonesia also apply this curriculum, and the number keeps growing. This paper will present the results of a study aiming to investigate the ideology, model, and elements of the International Baccalaureate (IB) curriculum, specifically the English (Language Acquisition) curriculum for the Middle Year Program (secondary school). The study has been given shape by the theory of curriculum development. The study employed a case study research design, especially text analysis. The results show that the English IB curriculum applies a learner-cantered ideology with collaborative learning to build students’ communicative skills. It also has been influenced by a deductive model proposed by Tyler. Moreover, the elements also confirm Tyler’s rationale, consisting of objectives, the content, learning activities or learning experiences designed to achieve the objectives various types of assessments and evaluations.
PURWARUPA SISTEM PENGENDALIAN DAN AKUISISI DATA PADA RUMAH CERDAS BERBASIS SMARTPHONE
Authors: Maulana Ryan , Wahyudi Wahyudi , Arfan Muhammad
Published: July 2022

Internet of Things (IoT) is the latest technology that has an extraordinary role in improving the quality of life and developing the world economy. IoT also known at community widely which is used to support global connectivity in various sectors, one of them is the smart home. Smart home is a new way in home appliances or equipment such as a lamp, air conditioner, heater and gate which is that equipment can be controlled remotely via the internet with the Human Machine Interface (HMI) system. On this final project, a prototype control and data acquisition system is designed for smart home based on smartphone. The system is designed using ATMega2560 and ESP8266 microcontrollers along with supporting sensors, while the HMI system is designed based on Android which can perform the functions of Supervisory Control and Data Acquisition (SCADA) namely measuring physical quantities (telemetering), notification of alarming systems (tele-signaling) and controlling home appliances easily and efficiently via the internet (tele-controlling). Sending and receiving data by the microcontroller to the server has an interval of 889 ms. The success rate and communication speed are influenced by internet connection and data traffic on the server. The data obtained in the telemetering system corresponds to the real situation of the smart home prototype. Tele-controlling and tele-signaling systems work well when operated.
ANALISIS PELIMPAHAN SEBAGIAN BEBAN UNTUK MEMINIMALKAN RUGI DAYA PENYULANG PLATINA KE PENYULANG FORD PT. PLN PERSERO UP3 PALEMBANG
Authors: Ridho Abdillah , Karnoto Karnoto , Darjat Darjat
Published: July 2022

Kebutuhan energi listrik menjadi sudah menjadi kebutuhan wajib di semua daerah. Di Kota Palembang pasokan energi diatur dan didistribusikan  melalui PT. PLN UP3 Palembang. Khusus di daerah Kenten, tenaga listrik yang pasok dan dibangitkan oleh PLTMG Sako Borang dan GI Kenten. Penyulang Platina dan Penyulang Ford merupakan bagian dari jaringan penyulang yang melayani wilayah tersebut. Menurut dari data rekap beban PT. PLN UP3 Palembang rugi daya Penyulang Platina masih mencapai 5,83% angka tersebut belum sesuai dengan target rugi daya PT. PLN UP3 Tahun 2021. Jatuh tegangan pada penyulang platina sebesar 9,27% (belum sesuai dengan SPLN 72:1987). Dalam tugas akhir ini dilakukan penelitian untuk mengetahui titik pelimpahan beban terbaik Penyulang Platina ke Penyulang Ford melalui metode algoritma genetika. Simulasi dan pencarian titik pelimpahan dilakukan dengan menggunakan software ETAP 16.0.0 dan MATLAB R2019a. Hasil yang diperoleh yaitu titik pelimpahan pada Penyulang Platina yaitu bus 101 (PLT 218) dan Penyulang Ford pada bus 248 (FRD 155). Rugi daya Penyulang Platina berkurang dari 5,83% menjadi 2,84%. Persentase jatuh tegangan turun dari 9,27% menjadi 5,88%. Hasil yang diperoleh tersebut telah sesuai dengan standar yang ditetapkan PT.PLN.
ANALISIS PENAMBAHAN RECLOSER PADA LOKASI YANG TEPAT GUNA MEMINIMALKAN NILAI SAIDI DAN SAIFI PENYULANG FORD BARU PT. PLN(PERSERO) UP3 PALEMBANG
Authors: Sasongko Bagas Aji , Karnoto Karnoto , Darjat Darjat
Published: July 2022

Pesatnya perkembangan teknologi dalam semua bidang menyebabkan kebutuhan akan energi lisrtik meningkat sehingga diperlukan sistem tenaga listrik dengan keandalan tinggi untuk menjaga kualitas kekontinyusan listrik. Pemasangan recloser merupakan salah satu cara dalam membantu peningkatan keandalan. Recloser berfungsi untuk memutus dan menyambungkan kembali aliran listrik secara otomatis. Pemasangan recloser akan mendapatkan hasil baik apabila didasari dengan perhitungan yang benar. Parameter yang digunakan dalam keandalan sistem tenaga listrik adalah SAIFI dan SAIDI. Nilai SAIFI dan SAIDI dapat dihitung dari tingkat laju kegagalan dan waktu pemadaman dari setiap komponen pada sistem. Semakin kecil nilai SAIFI dan SAIDI maka keandalannya akan semakin bagus. Pada penelitian ini akan dibuat program simulasi panambahan recloser menggunakan metode genetic algorithm pada software MATLAB R2016a. Dari hasil simulasi diperoleh bahwa SAIFI dan SAIDI setelah penambahan lebih kecil dari pada sebelum penambahan. Nilai SAIFI dan SAIDI sebelum penambahan recloser adalah 2,2756 kali/tahun dan 6,9454 jam/tahun. Setelah dilakukan perhitungan didapatkan nilai SAIFI dan SAIDI yang baik untuk 1 recloser yang berada pada lokasi 16 yaitu 0,69439 kali/tahun dan 2,2411 jam/tahun
RANCANGAN JARINGAN SALURAN PENALURAN POWER HOUSE PLTMH KE TITIK INTERKONEKSI DENGAN JALA-JALA DI SISTEM KELISTRIKAN DISTRIBUSI 20 KV JAWA TENGAH
Authors: Suryawijaya Muhammad Fauzan , Facta Mochammad , Sinuraya Enda Wista
Published: July 2022

Perencanaan PLTM Kambangan memiliki panjang 7,2 km dengan saluran penyaluran baru, namun tetap menggunakan titik acuan saluran eksisting yaitu titik B, C , D, E dan titik Power House PH. Perencanaan saluran baru ini berfokus pada desain konstruksi saluran penyaluran tenaga listrik dari PLTM hingga titik interkoneksi.  Selanjutnya dilakukan kalkulasi jatuh tegangan dan thermal pada saluran  dengan melakukan perbandingan antara perhitungan dan penggunaan software ETAP 16.0. Dalam studi desain konstruksi memilih penggunaan konduktor AAAC 70 mm2 dan penggunaan aksesorisnya. Dari analisis kalkulasi jatuh tegangan didapatkan dari hasil perhitungan titik PH ke E sebesar 0,28% , titik E ke D sebesar 0,408%, titik D ke C sebesar 1,62% dan titik C ke B sebesar 0,25% dalam kondisi Waktu Beban Puncak yang mengalami perbedaan dengan software ETAP yaitu secara berurutan sebesar 1,9%, 1,3%, 0,96%, dan 1,14%. Peralatan proteksi pada jaringan menggunakan LBS sebagai manuver jaringan dan Recloser untuk proteksi saat adanya gangguan dan juga koordinasi proteksi dengan saluran grid PLN.
IMPLEMENTASI DAN EVALUASI PERFORMA PEMBANGKIT LISTRIK TENAGA SURYA (PLTS) ON GRID STUDI KASUS SMP N 3 PURWODADI
Authors: Nur Diansyah Imam Fajar , Handoko Susatyo , Windarta Jaka
Published: July 2022

Indonesia memiliki potensi energi surya yang tinggi yaitu sebesar 207 GWp. Upaya yang dapat dijalankan untuk memaksimalkan potensi energi surya secara efisien adalah menerapkan pembangkit listrik tenaga surya (PLTS) di lokasi yang memiliki potensi energi matahari yang tinggi. Daerah Purwodadi di Provinsi Jawa Tengah memiliki potensi energi surya yang cukup tinggi sebesar 1,92 MWh/m2 per tahun. Tugas akhir ini dilaksanakan untuk merancang, mengimplementasikan, dan menganalisis kinerja PLTS sistem on grid dengan kapasitas 1350 Wp di SMP N 3 Purwodadi. Tugas akhir ini dimulai dengan perancangan dan pengimplementasian kemudian dilakukan pengujian komponen sistem PLTS selanjutnya dilakukan analisis produksi listrik oleh PLTS. Pengujian komponen dilakukan untuk mengetahui nilai daya input dan daya ouput sehingga nilai efisiensi dapat ditentukan. Berdasarkan hasil pengujian, didapatkan hasil bahwa larik panel surya memiliki efisiensi sebesar 15,3% dimana nilai efisiensi panel surya masih lebih rendah dari nilai pada datasheet yang disebakan karena suhu panel surya yang lebih tinggi dari suhu standar STC, sedangkan inverter memiliki efisiensi sebesar 97% yang mana sesuai dengan datasheet. Berdasarkan hasil monitoring selama dua bulan, PLTS mampu membangkitkan listrik hingga 361 kWh dengan rata-rata harian sebesar 5,92 kWh. Kemudian sistem PLTS memiliki nilai performance ratio 83% yang menandakan bahwa PLTS beroperasi dengan cukup baik dalam membangkitkan listrik.
PERANCANGAN KOMUNIKASI INTRA CLUSTER ANTARA NODE SENSOR DENGAN CLUSTER HEAD MENGGUNAKAN PERUTEAAN LEACH
Authors: Anjani Apriliani Nabila , Santoso Imam , Prakoso Teguh
Published: July 2022

Saat ini pemantauan tanaman hidroponik Kelompok Tani (Poktan) Dahlia dilakukan secara langsung mengikuti jadwal piket mingguan. Saat faktor lingkungan suhu dan kelembaban pada area tanaman hidroponik tidak berada pada range normalnya petani yang tidak mengetahui hal tersebut dapat terlambat mengambil tindakan. Hal ini akan berakibat tanaman mati dan merugikan kelompok tani. Jaringan Sensor Nirkabel atau JSN merupakan suatu jaringan yang terdiri dari sekumpulan node sensor yang tersebar pada suatu area target. Komunikasi intra cluster terdiri dari node sensor yang memiliki kemampuan untuk megumpulkan data besaran fisik pada lingkungan, memproses dan mengirimkannya hingga sampai ke pengguna. Node sensor umumnya berukuran kecil dan memakai catu daya berupa baterai sehingga memiliki energi yang terbatas Pemilihan rute pengiriman data dengan algoritma LEACH (Low Energy Adaptive Clustering Hierarchy) dapat membantu mengatasi masalah tersebut. Berdasarkan hasil analisis pada simulasi dengan menggunakan algoritma LEACH dapat mencapai round yang lebih lama yaitu 3455 round. Pada implementasi node sensor mampu melakukan penginderaan suhu dan kelembaban lingkungan. Arus yang dikonsumsi setiap node cukup seimbang dan mampu bertahan lebih lama. Kemudian selain pemilihan rute diterapkan juga mode deep sleep pada hardware untuk penjadwalan pengiriman. Mode deep dapat mengurangi rata-rata konsumsi arus pada node sensor 47,31% dan memperpanjang masa hidup rata-rata node sensor sebesar 89,14%. Perancangan komunikasi intra cluster antar node sensor dapat  melakukan fungsinya mengumpulkan data suhu kelembaban lingkungan dan meggunakan algoritma LEACH serta penjadwalan mode deep sleep dapat mengurangi konsumsi arus dan memperpanjang masa hidup JSN untuk pemantauan suhu dan kelembaban tanaman hidroponik Poktan Dahlia.
PERANCANGAN KOMUNIKASI INTER CLUSTER ANTARA CLUSTER HEAD DENGAN GATEWAY (NODE SINK) MENGGUNAKAN PERUTEAN LEACH
Authors: Fajrina Muthia Nur , Santoso Imam , Prakoso Teguh
Published: July 2022

Hidroponik adalah cara bercocok tanam dengan memanfaatkan air dan tanpa menggunakan tanah. Faktor-faktor yang mempengaruhi pertumbuhan hidroponik salah satunya adalah kondisi lingkungan yaitu suhu dan kelembaban. Akan tetapi pemantauan suhu dan kelembaban masih dilakukan secara manual. Oleh karena itu diperlukan suatu teknologi untuk memudahkan pemantauan. JSN atau Jaringan Sensor Nirkabel sebuah kumpulan node yang dapat berupa sensor yang akan melakukan pengambilan data dan mengirimkan informasi tersebut ke node sentral atau sebuah server. Isu utama yang masih menjadi permasalahan yaitu efisiensi energi pada JSN. Konsumsi energi pada jaringan menjadi hal yang penting agar dapat meningkatkan waktu hidup jaringan. LEACH (Low Energy Adaptive Cluster Hierarchy) adalah salah satu metode perutean model hierarki dalam JSN yang paling baik dalam hal efisiensi energi. Selain menerapkan perutean, untuk mengurangi konsumsi energi dan kemungkinan overheating, diterapkan juga sleep-wake up scheduling. Penerapan mode deep sleep dapat meminimalkan konsumsi energi pada perangkat keras sehingga masa hidup jaringan bisa bertahan lebih lama. Pada implementasi perangkat keras menggunakan LEACH dan penerapan penjadwalan pengiriman, arus yang dikonsumsi cluster head dan gateway lebih kecil. Penerapan mode deep sleep pada perangkat keras berhasil meningkatkan masa hidup cluster head hingga 83,17% dan gateway hingga 30,59%. Hasil pengujian keseluruhan sistem menunjukkan bahwa seluruh perangkat keras dapat berjalan dengan baik, sistem dapat mengirimkan data hingga jarak 30 meter dan sistem dapat mengeluarkan output berupa hasil pembacaaan nilai suhu dan kelembaban dengan rata-rata error secara keseluruhan untuk pembacaan suhu sebesar 3,54% dan kelembaban sebesar 7,7%.
Role of ERK signaling in bladder urothelium in response to cyclophosphamide injury
Authors: Narla Sridhar Tatarao , Duara Joanne Lindsey , Bushnell Daniel Scott , Nouraie Mehdi , Holden Jacqueline , Pfister Katherine , Lucas Peter C. , Sims‐Lucas Sunder , Bates Carlton Matthew
Published: July 2022

Mice with inducible urothelial deletion of fibroblast growth factor receptor 2 (ShhCreERT2;Fgfr2Fl/Fl) injured with cyclophosphamide had aberrant basal cell endoreplication and poor regeneration. The endoreplication correlated with an absence of phosphorylated (activated) ERK expression in urothelium. We assessed whether inhibiting ERK activity phenocopied the urothelial defects in injured Fgfr2 mutant mice. We co‐administered cyclophosphamide and an ERK inhibitor (ERKi) systemically in mice and assessed general histology and immunofluorescence for various markers post injury. Since AKT also signals downstream of FGFR2, we assessed effects of an AKT inhibitor (AKTi) on cyclophosphamide injury. ERK knockdown did not affect urothelial injury or proliferation 24 h after cyclophosphamide. Conversely, ERK inhibition led to larger basal cell nuclei, more submucosal hemorrhage and attenuated uroplakin staining 3 days after injury versus vehicle‐treated mice. Compared to vehicle‐treated mice, ERKi‐treated mice had a trend for more Ki67+ urothelial cells and had statistically fewer phospho‐Histone H3+ cells normalized to Ki67 and higher basal cell DNA content, consistent with endoreplication 3 days after injury. Ten days after injury, ERKi‐treated mice still had signs of poor urothelial regeneration with absent or aberrant expression of differentiation markers and ectopic lumenal expression of keratin 14 (basal progenitor marker). Co‐administration of the AKTi led to no apparent urothelial defects 3 days after cyclophosphamide. Thus, ERK knockdown (but not AKT knockdown) leads to urothelial regenerative responses after cyclophosphamide reminiscent of Fgfr2 mutant mice. Together, it appears that FGFR2 acts through ERK to prevent aberrant urothelial basal cell endoreplication and ensure normal regeneration after cyclophosphamide.
lncRNA HAGLR modulates myocardial ischemia–reperfusion injury in mice through regulating miR-133a-3p/MAPK1 axis
Authors: Wang Zi , Luo Wenqi , Zhong Peng , Feng Yifan , Wang Huaibin
Published: July 2022

Acute myocardial infarction is one of the leading causes of morbidity worldwide, but the underlying mechanism responsible for myocardial ischemia–reperfusion (I/R) injury remains elusive. lncRNA plays roles in inflammatory response, cell apoptosis and regulation of myocardial ischemia. However, whether lncRNA HAGLR could regulate myocardial I/R injury and the molecular mechanism need to be further investigated. lncRNA has been shown to bind to miRNAs and compete with endogenous RNAs. miR-133a-3p has been shown to regulate cardiomyocyte apoptosis and ischemic myocardial injury. In this work, it has shown that knockdown of HAGLR could suppress inflammatory response and cell apoptosis induced by I/R and, thus, alleviate myocardial I/R injury. HAGLR promoted myocardial I/R injury by inhibiting miR-133a-3p to promote MAPK1 expression.
Performance degradation detection method of aeroengine fuel metering device
Authors: Jin Xue , Li Wei
Published: July 2022

In order to realize the safety status monitoring and health management of aeroengine fuel system, a performance degradation detection method of aeroengine fuel metering device was proposed. Aiming at the internal leakage, external leakage, static friction increase, dynamic friction increase, differential pressure controller degradation, and other common performance degradation modes of fuel metering devices, a residual life estimation method based on random forest support vector regression (RF-SVR) was proposed. The SVR model optimized by RF feature selection is used to estimate the remaining life of components. The simulation results show that the mean square error of remaining useful life (RUL) estimation is less than 1.8, the average percentage error is less than 3%, and it has high prediction accuracy. Therefore, the evaluation and verification of the internal leakage health indicators proposed in this article screen out the health indicators that are sensitive to changes in performance degradation parameters but insensitive to changes in environmental and structural parameters and provide decision-making reference for onsite maintenance of engine fuel metering devices.
Research on contour feature extraction method of multiple sports images based on nonlinear mechanics
Authors: Wang Jucui , Li Mingzhi , Dziatkovskii Anton , Hryneuski Uladzimir , Krylova Aleksandra
Published: July 2022

This article solves the issue of long extraction time and low extraction accuracy in traditional moving image contour feature extraction methods. Here authors have explored deformable active contour model to research the image processing technology in scientific research and the application of multiple sports and the method. A B-spline active contour model based on dynamic programming method is proposed in this article. This article proposes a method of using it to face image processing and extracting computed tomography (CT) image data to establish a three-dimensional model. The Lyapunov exponent, correlation dimension and approximate entropy of the nonlinear dynamics algorithm were used to extract the features of eight types of motor imagination electroencephalogram (EEG) signals. The results show that the success rate of pose reconstruction is more than 97% when the contour extraction quality is relatively ideal. The method is also robust to image noise, and the success rate of pose reconstruction can reach 94% when the video image has large noise. The execution efficiency is sub-linear, which can basically meet the requirements of real-time processing in video-based human posture reconstruction. The proposed method has a low error rate in the calculation of curvature features, effectively reduces the time for extracting contour features of moving images, and improves the accuracy of feature information extraction.
InSAR terrain mapping error sources based on satellite interferometry
Authors: Li Genger
Published: July 2022

To improve the accuracy of interferometric synthetic aperture radar (InSAR) topographic mapping, an error source analysis method of InSAR topographic mapping based on satellite interferometry is proposed. According to the basic principle of InSAR altimetry, the preconditions of SAR satellite interferometry are quantitatively analyzed, and the phase error experiment is carried out. The error sources of formation satellite InSAR system are studied. Finally, the error sources affecting the formation satellite InSAR system are systematically analyzed. The experimental results show that this method has good analytical performance, quantitatively evaluates the propagation law of each error, and provides a basic reference for practical application.
Chimeric antigen receptor engineered T-cell therapy for central nervous system lymphoma
Authors: Sun Tiantian , Zhou Mi , Huang Liang
Published: July 2022

Central nervous system lymphoma (CNSL) includes primary and secondary subtypes. It is associated with poor prognosis even after aggressive therapies. Primary CNSL involves mainly the brain, eyes, leptomeninges and spinal cord, without evidence of systemic non-Hodgkin’s lymphoma (NHL). Secondary CNSL refers to involvement of the CNS secondary to systemic NHL. Chimeric antigen receptor T (CAR-T) cells are genetically engineered T-cells directed against tumor target antigens. CAR-T-cells have shown encouraging results in treating B-cell malignancies. Clinical data on CAR-T-cells in CNSL treatment are limited, because of concerns regarding the immunoprivileged status of the CNS and the possibility of immune effector cell-associated neurotoxicity syndrome. Clinical trials on CAR-T therapy for CNSL are increasingly being conducted to evaluate its efficiency and safety since CAR-T-cells have been detected in the cerebrospinal fluid from a patient with PMBCL who received CAR-T-cell therapy. Current data suggest that CAR-T-cells are an emerging therapeutic modality for CNSL with clinical benefits and acceptable adverse effects. However, whether CAR-T therapy may be a promising therapeutic avenue remains controversial, because evidence from large-scale randomized clinical trials remains lacking. Herein, we provide a review of existing clinical data on CAR-T-cell therapy for CNSL, discuss the limitations of CAR-T-cells in CNSL treatment and hypothesize strategies to overcome these challenges.
Scoring Eldest Souls (2021)
Authors: Ronchetti Sergio , Capstick Hannah
Published: July 2022

In this interview conducted by Hannah Capstick, composer and sound designer Sergio Ronchetti explores the process of creating music for the game Eldest Souls (Fallen Flag Studio, 2021), which was nominated for Best Audio for an Indie Game at the 20th Game Audio Network Guild (GANG) Awards. The interview covers topics including creating the game’s audio during the COVID-19 pandemic, the influence of metal on the score, first experiences of producing audio for a game, initial experiences in the industry, self-directed education, and Ronchetti’s design and career philosophies.
Standortbestimmung und Ideenwerkstatt: Was ist „zeitgemäßer“ öffentlich-rechtlicher Rundfunk?
Authors: Mayer Anna-Theresa
Published: July 2022

Vor dem Hintergrund aktueller Debatten über die Leistung des öffentlich-rechtlichen Rundfunks besonders im Umgang mit der Digitalisierung und seiner Rolle in der Gesellschaft fand vom 24. bis 26. März 2022 bei der Akademie für Politische Bildung die Tagung der Tutzinger Journalistenakademie „Zeitgemäßer öffentlich-rechtlicher Rundfunk (?). Ein konstruktiver Streit“ statt. Über drei Tage hinweg tauschten sich Medienschaffende und -forschende, Journalist*innen und interessierte Bürger*innen über die Lage des öffentlich-rechtlichen Rundfunks aus. Doch dabei blieben sie nicht stehen: In einer Ideenwerkstatt entwickelten die Teilnehmenden neue Formate und Konzepte für eine zukünftige Gestaltung des öffentlich-rechtlichen Rundfunks, die zum Schluss eine Jury bewertete.
Особливості мотивації юнаків 16-17 років до фізкультурно-оздоровчих занять з елементами акварекреації
Authors: Підгайна Віра
Published: July 2022

В статті розглянуто можливі шляхи застосування акварекреації в процесі фізкультурно-оздоровчих занять для юнаків 16-17 років. Метою даного дослідження є – обґрунтування системи підходів щодо формування мотивації до фізкультурно-оздоровчих занять з елементами акварекреації учнівської молоді. Матеріали та методи дослідження: для вирішення поставленої мети ми використовували такі методи дослідження: теоретичний аналіз та узагальнення даних наукової літератури та даних мережі Інтернет; анкетування; методи математичної статистики. На основі аналізу науково-методичної літератури та даних мережі Інтернет вдалося визначити основні напрямки та пріоритети використання акварекреації для подальших досліджень. Застосування таких фізкультурно-оздоровчих занять дозволить вирішити ряд актуальних проблем у сучасному молодіжному дозвіллі.
Scale and Consequences of Forced Migration of the Population of Ukraine as a Result of Armed Aggression of the Russian Federation
Authors: LIBANOVA E. M. , POZNIAK O. V. , TSYMBAL O. I.
Published: July 2022

The article is devoted to the assessment of the scale and consequences of forced external and internal migration due to the active phase of the Russia-Ukraine war. The urgency of the work is due to the need for scientific understanding of migration trends formed after February 24, 2022 and the lack of analytical research on migration in this period. The purpose of the article is to assess the scale of forced migration of the population of Ukraine both within the country and abroad. The novelty of the study is to identify the consequences of large-scale migratory movements, which began on February 24, 2022, and develop recommendations for their regulation. The research methodology is based on the use of rather eclectic information from open sources, expert opinions and assessments, etc., in conditions when the production of official statistics is stopped, conducting sample surveys, at least “face to face”, is extremely difficult. The trends of forced migration within Ukraine and abroad have been assessed. It was established that the active departure of the population from Ukraine was observed in the first weeks of the open war phase, after that the flow of refugees slowed down. According to Ptoukha Institute for Demography and Social Studies of the NAS of Ukraine, based on data from the State Border Guard Service, the number of war refugees from Ukraine is 3.1-3.2 million people, but there is a risk of significant increase. Possible amounts of irreversible migration losses, depending on the impact of military and economic factors, will range from 600-700 thousand people to 5.0-5.5 million. The number of those who were forced to change their place of residence within Ukraine is estimated at 5.0-5.5 million. The factors of return of forced migrants to Ukraine are identified, the consequences of large-scale forced migrations are assessed, and recommendations for their regulation are proposed. It is concluded that a more accurate estimate of the number of both IDPs and forced external migrants requires the development of comprehensive methodology that will take into account data from various sources and adequate information provision (in particular, the introduction of sample surveys in Ukraine and abroad on a regular basis). Validation of performed assessments data is possible after the census.
Developing Manipulative Basic Movement Learning Model Based on Traditional Games in Elementary Schools
Authors: Rejeki Hendriana Sri , Humaedi Humaedi , Ardiansyah A.
Published: July 2022

This study aims to develop manipulative basic movement learning models based on tradition games at Elementary schools. Research and development method adopted from Borg and Gall was used. The effectiveness of the application of the manipulative basic motion learning model and catch and capture in these students used the "t-test" technique. Before the data were analyzed, the normality test was carried out on the pretest and posttest results of the basic motion manipulative and catch-and-catch using the Kolmogorov Smirnov test at the real level α = 0.05. The results of the manipulative basic motion of throwing catch between the pretest and posttest were obtained at a value of -24,645 at a significance of 0,000. So it can be concluded that the increase in the basic manipulative movement ability of throw and catch before and after learning has increased significantly. The contribution of the basic manipulative motion learning model of catch and capture is 42.21% based on the effectiveness test data at SD Tanamodindi and SD Inpres Lasoani.
Online English Language Teaching in the Midst of Covid-19 Pandemic: Non EFL Students' Feedback and Response
Authors: Sukmawati Sukmawati , Sujarwo Sujarwo , Soepriadi Dewi Nidia , Amaliah Nurul
Published: July 2022

The Covid-19 pandemic has changed the order of learning that has been carried out by lecturers at universities. Learning shifted from traditional to online. Online learning is one of the main strategies that must be carried out by lecturers in order to ensure that the learning process continues. The study aims to determine students’ responses and feedbacks during online learning in English courses during Covid - 19. The research method used descriptive quantitative method. Data were taken using questionnaires and interviews. The questionnaire was prepared through Google Form and a link was sent to students, and lecturers via WhatsApp. The population and sample in this study were students of the DIII TLM study program, S1 Pharmacy, S1 PGSD and S1 ARS at Universitas Megarezky who took English courses. The instrument used is a response questionnaire and student feedback during online learning. Based on data processing and analysis that online learning carried out by lecturers in English courses has been effective, efficient, varied, helping students understand the material, forming independent learning, and increasing student active participation in learning. There are several important findings regarding online learning during the COVID-19 pandemic. Zoom, WhatsApp and Google Classroom are the most widely used applications as learning media. There are several obstacles experienced by teachers and students during the implementation of online learning related to internet access and quotas. Both students and teachers long for face-to-face learning activities directly in the classroom. Both students and teachers long for face-to-face learning activities directly in the classroom. Zoom, WhatsApp and Google Classroom are the most widely used as learning media. There are several obstacles experienced by teachers and students during the implementation of online learning related to internet access and quotas. Both students and teachers long for face-to-face learning activities directly in the classroom.
The resilience of VET: Managing economic shocks, ageing, and technological change in an age of uncertainty
Authors: Hogarth Terence
Published: July 2022

Since the mid 1990s vocational and education and training systems across Europe have had to respond to a number of external factors which have transformed the demand for skills. This paper examines the way in which VET systems have responded to the external factors and increase their resilience in the face of external shocks of one kind or another. The paper also reveals the way in which VET increasing established itself as a mainstream option for young people over the same period because of its capacity to deliver skills which the labour market demands.
Faith-Based Women’s Organization Philanthropy in Fighting against the COVID-19 pandemic and Its Impacts: The Case of Aisyiyah in Sidoarjo, Indonesia
Authors: Hazim Hazim , Fihayati Zuyyina
Published: July 2022

Since the emergence of the global COVID-19 pandemic, faith-based philanthropic activities have become widely attractive topics to be investigated. Yet, there has been little exploration related to gender issues. This study examined faith-based women’s engagement in dealing with the COVID-19 outbreak and its impacts focusing on a local context in Sidoarjo, Indonesia. Notably, the investigation aimed to explore the extent to which Aisyiyah's philanthropy in addressing the global issue. To achieve the purpose of the study, it carried out a qualitative method incorporating three data collection techniques: semi-structured interview involving 17 informants; participant observation focused on Aisyiyah’s programs conducted to overcome the COVID-19; and a desk study gained from documents, reports, media (and social media) such as Facebook, Twitter, and YouTube channels. The result delineates that while some scholars divide two paradigms of community engagement which are utilitarian and social justice, Aisyiyah in Sidoarjo has played vital contributions oriented toward social justice. This approach has been done through various programs; public awareness building, embracing the COVID-19 patients, and enhancing social solidarity to reduce the outbreak effects. These findings contribute to filling the literature gap on religious-based women's philanthropy in dealing with the pandemic. However, it is critical to explore the extent to which Aisyiyah's commitment to humanitarian activities for a long-term period since no one can even predict when it will end. Another pivotal issue that needs further investigation is Aisyiyah’s way in mobilizing social capital to support its philanthropic activities.
School-based factors affecting Grade 12 accounting learners’ performance in the General Certificate Secondary Examination (GCSE) in Eswatini
Authors: Mkhize Msizi Vitalis , Mtshali Muntuwenkosi Abraham , Sithebe Khumbuzile
Published: July 2022

In the sequential explanatory mixed methods study reported on here we examined school-based factors contributing to the poor performance of Grade 12 accounting learners’ the GCSE in the Lubombo and Manzini regions of Eswatini. The random sample for the quantitative phase comprised 400 accounting learners and 80 accounting teachers from 10 schools performing well, achieving good results, and 10 schools performing poorly, achieving low quality results. Purposive sampling was used for the qualitative phase to select 6 learners and 4 teachers from schools that performed well, and 6 learners and 4 teachers from schools that performed poorly. The data collection instruments were questionnaires and semi-structured interviews. Quantitative data were analysed using the Statistical Package for Social Sciences (SPSS), while thematic analysis was used for the qualitative data. Incongruities existed between learners’ and teachers’ perceptions of the school-based factors affecting Grade 12 accounting learners’ performance in the GCSE in Eswatini. The quantitative results indicate the variables contributing to poor learner performance in accounting as lower period allocation; checking of learners’ work; setting a minimum on the number of tests per term; timely delivery of textbooks; provision of study time; discussion of results, and motivation of teachers and learners. Teachers, on the other hand, felt that the variables affecting learners’ performance were setting a minimum on the number of tests per term; awarding pupils for good performance; placing emphasis on science subjects; the provision of reference material; motivation of teachers and learners; checking of learners’ work; subject combinations; lower period allocation; discussion of results, and timely delivery of textbooks. The qualitative results reveal that learners identified common school variables contributing to their poor performance as not receiving textbooks on time, their work not being checked, and a lack of parental involvement. Teachers identified delivery of textbooks, emphasis on science subjects, and teachers’ poor motivation and administration as school variables contributing to learners’ poor performance in accounting. The relationships between school variables and demographic variables were found to be low. This study offers insight into what secondary school accounting teachers in emerging economies may experience as variables that affect learners’ performance in accounting, and the need to pursue pedagogical practices that can respond to these variables.
A Stochastic Mobility Prediction Algorithm for finding Delay and Energy Efficient Routing Paths considering Movement Patterns in Mobile IoT Networks
Authors: Lozano-Garzón Carlos , Montoya Germán A. , Donoso Yezid
Published: July 2022

In Mobile IoT Networks, the network nodes are constantly moving in a field, causing interruptions in the communication paths and, thus, generating long delays at the time of building a communication path from a source IoT node to the gateway (destination node). Communication interruptions affect the delay performance in delay-sensitive applications such as health and military scenarios. In addition, these IoT nodes are equipped with batteries, whereby it is also necessary to accomplish energy consumption requirements. In summary, a gateway node should not receive messages or packets coming from the IoT nodes with undesired delays, whereby it is pertinent to propose new algorithms or techniques for minimizing the delay and energy consumption experimented in the IoT network. Due to IoT nodes are attached to humans, animals or objects, they present a specific movement pattern that can be analyzed to improve the path-building with the aim of reducing the end-to-end delay. Therefore, we propose the usage of a mobility prediction technique based on a Stochastic Model to predict nodes’ positions in order to obtain minimum cost paths in terms of energy consumption and delay in mobile IoT networks. Our stochastic model is tuned and evaluated under the Markov-Gauss mobility model, considering different levels of movement randomness in order to test how the capability prediction of our proposal can impact the delay and energy consumption in mobile IoT networks in comparison with others routing algorithms.