bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of Posttraumatic Stress Disorder and Depression on Paternal Attachment to High-Risk Infants
Authors: Lee Yu Jin , Ju Hyeon Ok
Published: January 2024

Purpose: This study has sought to determine the levels of posttraumatic stress disorder (PTSD), depression, and attachment among fathers raising high-risk infants and to identify the factors influencing paternal attachment.Methods: The participants were 85 fathers who were raising high-risk infants aged 6 months or younger and visiting a general hospital in Busan Metropolitan City. A structured questionnaire was administered to collect information on the general characteristics of fathers and children, PTSD, depression, and attachment. Hierarchical regression analysis was conducted to identify the factors associated with paternal attachment.Results: The average scores reported by fathers were as follows: 4.68±0.27 out of 5 for attachment, 19.51±15.40 out of 88 for PTSD, and 13.21±10.07 out of 60 for depression. Among fathers, 29.4% and 20% experienced PTSD and depression, respectively. The first model revealed that the use of a ventilator, the age of the infant, and desired sex of the infant were associated with paternal attachment, predicting 30% of the variance. In the second model, in which PTSD and depression were added, PTSD influenced paternal attachment. This model predicts a 52% variance.Conclusion: The formation of paternal attachment, which begins immediately after a child’s birth, plays a crucial role in a child’s cognitive, emotional, and social development. To enhance the attachment of fathers raising high-risk newborns, neonatal nurses should screen fathers for PTSD early and plan appropriate interventions.
The Indigo Project: Participatory Action Research with Gender and Sexual Minority Survivors of Elder Abuse
Authors: Robson Claire , Marchbank Jen , Gutman Gloria
Published: January 2024

Though research suggests that older adults belonging to gender and sexual minorities (GSM) are at greater risk of abuse and neglect, more needs to be done to investigate this situation, provide solid data, offer support to survivors and better inform those providing services. This article reports on a participatory action research project in which nine older adults with lived experience of abuse were interviewed, as were the seniors’ programmer from our community partner organization and a trauma counsellor who supported our participants throughout the project. Participants were interviewed at least twice, often more, and the resulting interview transcripts were edited with the help and consent of the participant concerned, to form narratives which were content-analyzed. The goals of the project were to raise awareness of the underreported issue of abuse of elder GSM individuals, to consider how elder abuse might both differ and look the same as it does in the mainstream population, and to offer mental health supports and safe spaces for healing for our participants. This deep dive into lived experience illuminates how homophobia and transphobia (both historic and contemporary) play out in subtle and complex ways. We conclude with recommendations for researchers and care/service providers.
Unpacking the Experiences of Health Care Professionals About the Web-Based Building Resilience At Work Program During the COVID-19 Pandemic: Framework Analysis
Authors: Ang Wei How Darryl , Lim Zhi Qi Grace , Lau Siew Tiang , Dong Jie , Lau Ying
Published: January 2024

Background

The COVID-19 pandemic has resulted in a greater workload in the health care system. Therefore, health care professionals (HCPs) continue to experience high levels of stress, resulting in mental health disorders. From a preventive perspective, building resilience has been associated with reduced stress and mental health disorders and promotes HCPs’ intent to stay. Despite the benefits of resilience training, few studies provided an in-depth understanding of the contextual factors, implementation, and mechanisms of impact that influences the sustainability of resilience programs. Therefore, examining target users’ experiences of the resilience program is important. This will provide meaningful information to refine and improve future resilience programs.

Objective

This qualitative study aims to explore HCPs’ experiences of participating in the web-based Building Resilience At Work (BRAW) program. In particular, this study aims to explore the contextual and implementational factors that would influence participants’ interaction and outcome from the program.

Methods

A descriptive qualitative approach using individual semistructured Zoom interviews was conducted with participants of the web-based resilience program. A framework analysis was conducted, and it is guided by the process evaluation framework.

Results

A total of 33 HCPs participated in this qualitative study. Three themes depicting participants’ experiences, interactions, and impacts from the BRAW program were elucidated from the framework analysis: learning from web-based tools, interacting with the BRAW program, and promoting participants’ workforce readiness.

Conclusions

Findings show that a web-based asynchronous and self-paced resilience program is an acceptable and feasible approach for HCPs. The program also led to encouraging findings on participants’ resilience, intent to stay, and employability. However, continued refinements in the components of the web-based resilience program should be carried out to ensure the sustainability of this intervention.

Trial Registration

ClinicalTrials.gov NCT05130879; https://clinicaltrials.gov/ct2/show/NCT05130879
Participation in Advance Care Planning Among Medically At-Risk Rural Veterans: Protocol for a Personalized Engagement Model
Authors: Walkner Tammy , Karr Daniel W , Murray Sarah , Heeren Amanda , Berry-Stoelzle Maresi
Published: January 2024

Background

Many of the challenges in advanced care planning (ACP) conversations are linked to the waxing and waning progress of serious illnesses. Conversations with patients about future medical care decisions by a surrogate decision maker have historically been left until late in the patient’s disease trajectory. These conversations often happen at a time when the patient is already very ill. The challenge in effective early ACP and serious illness conversations is to create a situation where patients appreciate the link between current and future medical care. Setting the stage to make these conversations more accessible includes using telehealth to have conversations at the patient’s place of choice. The personalization used includes addressing the current medical and social needs of the patient and ensuring that expressed needs are addressed as much as possible. Engaging patients in these conversations allows the documentation of patient preferences in the electronic health record (EHR), providing guidelines for future medical care.

Objective

The objective of our telehealth serious illness care conversations program was to successfully recruit patients who lacked up-to-date documentation of ACP in their EHR. Once these patients were identified, we engaged in meaningful, structured conversations to address the veterans’ current needs and concerns. We developed a recruitment protocol that increased the uptake of rural veterans’ participation in serious illness care conversations and subsequent EHR documentation.

Methods

The recruitment protocol outlined herein used administrative data to determine those patients who have not completed or updated formal ACP documentation in the EHR and who are at above-average risk for death in the next 3-5 years. The key features of the telehealth serious illness care conversations recruitment protocol involve tailoring the recruitment approach to address current patient concerns while emphasizing future medical decision-making.

Results

As of September 2022, 196 veterans had completed this intervention. The recruitment method ensures that the timing of the intervention is patient driven, allowing for veterans to engage in ACP at a time and place convenient for them and their identified support persons.

Conclusions

The recruitment protocol has been successful in actively involving patients in ACP conversations, leading to an uptick in completed formal documentation of ACP preferences within the EHR for this specific population. This documentation is then available to the medical team to guide future medical care.

International Registered Report Identifier (IRRID)

RR1-10.2196/55080
Táctica y estrategia: resiliencia ambiental para el análisis y la gobernanza territorial
Authors: Arias Hernández Jazmín
Published: January 2024

En la mayoría de los casos, la gestión territorial se orienta al desarrollo de proyectos o acciones para dar respuesta a necesidades que el gobierno (nacional, regional o local) identifica desde sus propias perspectivas, pero sin considerar las interacciones complejas entre los componentes de los territorios, el efecto de disturbios episódicos o continuos, la capacidad de respuesta territorial ante estos tensores, y los imponderables. Por tal razón, y considerando la resiliencia ambiental como una herramienta que puede contribuir eficazmente a la gobernanza territorial, principalmente a nivel local, para su gestión contextualizada, el objetivo de este artículo es proponer una metodología para valorar la resiliencia ambiental territorial. Esto se lleva a cabo a través de algunas consideraciones teóricas, el análisis de la pertinencia de los estudios territoriales bajo la lente de la resiliencia y una propuesta metodológica previamente validada para el diagnóstico integral de la resiliencia de los territorios ante tensores internos o externos. Eso se hace considerando los aspectos ecosistémicos, socioculturales y político-económicos determinantes, con el propósito de contar con información suficiente y adecuada para generar estrategias de gobernanza orientadas a crear o fortalecer su grado de resiliencia. Así, se plantean finalmente los aspectos más importantes a considerar para la propuesta de dichas estrategias, garantizando una implementación coherente con las realidades territoriales locales, la participación y corresponsabilidad de los actores y actoras presentes, y la capacidad adaptativa del proceso.
La importancia de evaluar el daño al DNA
Authors: Rojas Lemus Marcela , López Valdez Nelly , González Villalva Adriana , Bizarro Nevares Patricia , Cervantes Valencia María Eugenia , Casarrubias Tabarez Brenda , Fortoul Teresa I.
Published: January 2024

It is estimated that the human body is made of trillions of cells, which suffer hundreds of thousands of DNA lesions every day. Although DNA is not the only biomolecule that suffers damage, its importance lies in the fact that it is the only biomolecule that cannot be replaced by the cell, so when it suffers damage, the cell must repair it, tolerate or, in a extreme case, activate pathways that will lead to death, since the objective is to maintain cell integrity and the homeostasis of the organism.There are thousands of agents that can damage DNA, some are produced by the cell and are called 'endogenous, while others are external agents and are known as 'exogenous. The cell cannot avoid the damage caused by endogenous agents, since they are products of its metabolic activity, for example, so when they occur, cellular mechanisms are immediately activated to mitigate them. The same happens with the damage caused by exogenous agents, since the cell will do everything possible to diminish the adverse effects they can cause. The problem becomes apparent when the cell is unable to repair the damage or poorly repairs it, or repairs so much that the mechanisms are overwhelmed, when the damage remains in the DNA and a state of chromosomal instability is generated that can lead the cell to dysfunction and malignization. This state of chromosomal instability can be reflected in increased DNA breaks or micronuclei in exposed cells, which can be quantified by special methods such as the 'Comet Assay' and the 'Micronucleus Assay'. Since identifying DNA damage is a way of evaluating the toxic potential of the agents to which populations are exposed, it allows us to know their mechanisms of action and helps to understand the factors that influence the detriment in population's health. Key words: DNA damage; genotoxic evaluation; repair; Comet Assay; micronuclei.
Tumor de Buschke-Löwenstein en el embarazo adolescente
Authors: Sotres Guerrero Alejandra Ivonne , Adame Caballero José Emmanuel
Published: January 2024

Background: Buschke-Löwenstein tumor also called giant condyloma acuminatum is a rare condition due to the human papillomavirus with an incidence of 0.01% and just 6 cases reported in pregnancy. There is no consensus on the treatment, although surgery has been the most reported.
Enfermedad de Castleman: un enfoque integral a propósito de un reporte de caso
Authors: Vergara Bolaño Armando , León Sierra Paula Andrea , Villagrán Uribe Jesús Ángel , Galván Navarrete Marisol
Published: January 2024

The clinical case of a 30-year-old female patient with supraclavicular and ipsilateral axillary lymphadenopathy who underwent excisional biopsy with subsequent study is presented. Histopathological analysis of the resected tissue sample revealed a series of distinctive features associated with hyaline vascular variant Castleman disease. The presentation of this case not only provides detailed information about the clinical evolution of the patient, but also serves as a basis to illustrate Key aspects of histopathological is and immunohistochemical implications in Castleman disease. In addition to making a review of the topic regarding this rare pathology in which case reports are essential to increase the understanding of its clinical variability and its diagnostic approach, illustrating the challenges in differential diagnosis and how they should be addressed. Key words: CASTLEMAN, LYMPHOMA, LYMPHADENOPATHY, HYALINE VASCULAR, PLASMA CELLS
Synergy between deep neural networks and the variational Monte Carlo method for small 4HeN clusters
Authors: Freitas William , Vitiello S. A.
Published: January 2024

We introduce a neural network-based approach for modeling wave functions that satisfy Bose-Einstein statistics. Applying this model to small 4HeN clusters (with N ranging from 2 to 14 atoms), we accurately predict ground state energies, pair density functions, and two-body contact parameters C2(N) related to weak unitarity. The results obtained via the variational Monte Carlo method exhibit remarkable agreement with previous studies using the diffusion Monte Carlo method, which is considered exact within its statistical uncertainties. This indicates the effectiveness of our neural network approach for investigating many-body systems governed by Bose-Einstein statistics.
Prosumer Empowerment through Community Power Purchase Agreements
Authors: Dumitrescu Raluca , Lüth Alexandra , Weibezahn Jens , Groh Sebastian
Published: January 2024

To achieve the United Nation's Sustainable Development Goal 7 “Clean and Affordable Energy”, the most economically viable option for servicing the part of the population that is too remote or for which the national grid extension is too expensive are distributed renewable energy solutions (DREs), that is, standalone solar home systems (SHSs), mini grids, and swarm gridsi. By 2030, more than 290 million people could be connected to mini grids. Following a top-down approach to electricity access, countries of the Global South, with support of international aid and development funding, are accelerating their national grid expansion. As the national grid reaches their customers, the private sector (DRE companies) is put at danger of having to either relocate their assets or abandon them. At the same time, the DRE end-user, reached by the national grid, faces several challenges due to being exposed to a double infrastructure. These challenges can be of technical and financial nature and are caused by the assets becoming abundant or needing additional equipment to be suitable for national grid and DREs. In our new paper we investigate a technically and economically viable solution for the co-existence of the national grid−a centralized infrastructure−with mostly decentralized, renewable energy infrastructure in Global South countries. At the intersection of these two electrification pathways the question arises if the two approaches can be integrated to the benefit of society by maintaining existing assets. We assume the technical link to be a bidirectional inverter and a battery representing the point of common coupling (PCC) between national grid and currently off-grid systems. We then suggest to apply a cost recovery approach to calculate the economic value of a community power purchase agreement (C-PPA) that allows the community to enter into a trade agreement with the national grid to export at a specified rate.
Conclusions on Integrated Network Planning in Europe: The STEERS Project
Authors: Brandstätt Christine , Llorca Manuel , Lüth Alexandra , Weibezahn Jens , Jamasb Tooraj
Published: January 2024

Network planning is central to a future-proof energy system that is viable within the framework of the European Green Deal and suitable for energy systems integration. The new TEN-E regulation underlines this for European energy networks. The STEERS project aimed at aiding the implementation of its goals, i.e., system integration, the energy efficiency first principle, as well as the improvement of transparency and openness in the planning of energy networks in the European Union, and specifically in the TYNDP process. In this policy brief, we sum up the main conclusions.
Bayesian Network Training Method to Produce a Condition-Based Maintenance Strategy in Aviation Maintenance Programs
Authors: Ha Seongjun , Yother Tracy , Yang Chuyang
Published: January 2024

With an understanding of the current industry and organization orientation, the aviation maintenance industry is preparing a new paradigm shift toward a CBM (Condition-Based Maintenance) strategy. However, one challenge the aviation maintenance industry faces is the lack of CBM training support in the current education setting. This study aims to fill the gap in the CBM strategy training in current aviation maintenance programs. The authors propose Condition-Based Maintenance Bayesian Network (CBM-BN) training materials. The BN has a different principal approach than other frequentist principles, which can generate a prediction model concerning all heterogeneous information. In this paper, the authors describe a framework to develop CBM-BN training material that can be performed in aviation maintenance education. The proposed CBM-BN framework has probability concepts and ten steps; each step has three sections, including materials, activities, and examples for instructors and students. The case study demonstrates that the developed CBM-BN framework and training materials could facilitate CBM strategy training in aviation maintenance programs. A mechanic who can do CBM analysis will be more beneficial and demandable in the job market and contribute to full CBM implementation. Moreover, other CBM educational materials would be needed to compensate for the limitations of BN and increase the maturity level of CBM.
The Antitumor Effect of Antipsychotic Thioridazine in Chronic Myeloid Leukemia is Mediated by Intracellular Ca2+ and Mitochondrial Permeabilization
Authors: Moraes Vivian , Matsukura Vivian , Suarez Eloah , Ferraz Leticia , Mognol Giuliana , Campeiro Joana , Nascimento Fabio , Hayashi Mirian , Tersariol Ivarne , Newmeyer Donald , Rodrigues Tiago
Published: January 2024

Although tyrosine kinase inhibitors have revolutionized treatment for
chronic myeloid leukemia (CML), some patients exhibit drug resistance
and poor clinical outcomes. Here, we explore the mechanistic aspects of
cytotoxicity produced by thioridazine (TR). TR is an antipsychotic drug
that has been investigated for its anticancer potential in a
Philadelphia-positive human CML model. Our data show that TR selectively
induced apoptosis in K562 cells compared with normal blood cells, which
was mediated by Ca2+ and mitochondrial permeabilization. TR-induced cell
death was accompanied by changes in Bcl-2 proteins and endoplasmic
reticulum stress. TR also exhibited potent cytotoxicity against
BCL-2/BCL-xL-overexpressing leukemia cells and presented an antitumor
effect in vivo. These findings emphasize the high pharmacological
potential of TR as an adjuvant in CML chemotherapy.
On the Solution of Cubic KdV Boussinesq Equation Using Two Reliable Techniques for Propagation of Shallow Water Waves
Authors: GUPTA ARUN KUMAR , Hazarika Jyotishman
Published: January 2024

In this article, generalized Kudryashov technique has been implemented
to construct new soliton solutions of cubic KdV Boussinesq equation.
Also, the OHAM has been employed to compute the numerical solution. The
solutions thus acquired by the above methods are illustrated
graphically. The techniques considered here are efficacious, plausible
and can be employed in mathematical physics to compute new exact and
numerical solutions of NPDEs.
COVID-19 and Hereditary Angioedema (HAE): Incidence, Outcomes and Mechanistic Implications
Authors: Veronez Camila Lopes , Christiansen Sandra , Smith Tukisa , Riedl Marc , Zuraw Bruce
Published: January 2024

Background: HAE patients have been postulated to be at increased risk
for COVID-19 infection due to inherent dysregulation of the plasma
kallikrein-kinin system. Only limited data has been available to explore
this hypothesis. The aim of this study was to assess the
interrelationship(s) between COVID-19 and HAE. Methods: Self-reported
COVID-19 infection, complications, morbidity and mortality were surveyed
using an online questionnaire. Subjects included HAE with C1 inhibitor
deficiency (HAE-C1INH), normal C1 inhibitor (HAE-nl-C1INH and household
controls. The impact of HAE medications was examined. Results: 1445
participants completed the survey, including: 695 HAE-C1INH, 175
HAE-nl-C1INH, and 292 controls. The incidence of reported COVID-19 was
not significantly different between controls (9%) and HAE-C1INH (11%)
but was greater in HAE-nl-C1INH (19%, p=0.006). Obesity was positively
correlated with COVID-19 across the overall population (16% vs 10%,
p=0.012), with a similar but non-significant trend in HAE-C1INH (14% vs
9%). Co-morbid autoimmune disease was a risk factor for COVID-19 in
HAE-C1INH (p = 0.047). COVID-19 severity and complications were similar
in all groups. Reported COVID-19 was reduced in HAE-C1INH subjects
receiving prophylactic subcutaneous C1INH (5.6%, p=0.0371) or on-demand
icatibant (7.8%, p=0.0016). HAE-C1INH subjects not on any HAE
medications had an increased risk of COVID-19 compared to normal
controls (24.5%, p=0.006). Conclusions: HAE-C1INH subjects not taking
HAE medications had an enhanced risk for COVID-19 infection.
Subcutaneous C1INH and icatibant significantly reduced this risk. The
results implicate roles for the complement cascade as well as
non-contact system related kinin generating pathways in the pathogenesis
of COVID-19 in HAE-C1INH.
Coronavirus Disease 2019 (COVID-19) in Pregnancy and the Risk of Hypertensive Disorders of Pregnancy: A Retrospective Cohort Study
Authors: Baracy Michael , Afzal Fareeza , Szpunar Susanna , Tremp MaKenzie , Grace Karlee , Liovas Marina , Aslam Muhammad
Published: January 2024

Objective: To evaluate the association of COVID-19 status in pregnant
women and hypertensive disorders of pregnancy. Design: Retrospective
Cohort Study Setting: Multicenter study from a large metropolitan
hospital system Population: Pregnant patients who tested positive for
COVID-19 Methods: Patients who tested positive for COVID-19 during their
pregnancy and delivered (index cases) were compared to the three
subsequent deliveries of patients who tested negative (controls) at the
same institution. We evaluated the impact of COVID-19 on the development
of hypertensive disorders of pregnancy. We also evaluated the
association of these disorders with maternal characteristics;
demographics; prior pregnancy complications; current pregnancy
complications; COVID-19 severity; laboratory values and inflammatory
markers; and maternal and fetal outcomes. Univariable analysis was
conducted with Student’s t-test, the chi-squared test and analysis of
variance. Multivariable analyses were done using linear and logistic
regression models. Main Outcome Measures: The incidence of hypertensive
disorders of pregnancy in SARs-CoV-2 positive patients compared to
SARs-CoV-2 negative patients. Results: Compared with pregnancies
negative for SARs-CoV-2 infection, maternal SARs-CoV-2 infection was
associated with an increased risk for hypertensive disorders of
pregnancy (OR 3.68, 95% CI 1.67 -8.10). Overall rates of preeclampsia
with severe features were significantly higher in patients with a
COVID-19 diagnosis (18.6% vs 7.1%, p=0.006). An early SARS-CoV-2
infection (prior to 32 week’s gestation) conferred a higher risk of
hypertensive disorders in pregnancy compared to SARs-CoV-2 infections
diagnosed after 32 weeks’ gestation(OR=6.29, CI 1.64-24.07; p=0.007).
Conclusion: COVID-19 is a risk factor for hypertensive disorders of
pregnancy. Funding: None Conflicts of Interest: None
Predictors of high flow nasal cannula failure in pediatric acute respiratory distress
Authors: saelim kantara , Thirapaleka Busawan , Ruangnapa Kanokpan , Prasertsan Pharsai , Anuntaseree Wanaporn
Published: January 2024

Background: Recently, heated humidified high flow nasal cannula (HFNC)
has gained popularity, and is now considered as standard respiratory
support for pediatric patients with acute respiratory distress. However,
there is limited data concerning bedside parameters for prediction of
HFNC failure in pediatric patients. Material and method: A prospective
observational study was conducted in 1 month to 15 year old patients
with acute respiratory distress that required high flow nasal cannula
support. The setting of high flow nasal cannula, vital signs, clinical
respiratory score and the outcome of treatment were recorded. Data were
analyzed to determine the predictors of HFNC failure. Results: In total
82 children participated in the study; from which 16 children (19.5%)
did not response to high flow treatment (failure group). Pneumonia was
the main reason for intubation (62.5%). Predictors of high flow nasal
cannula failure at 12 hours were: SF index ≤ 166 (sensitivity 87.8%,
specificity 62.5%, AUC 0.75), pROX index < 132 (sensitivity
84.8%, specificity 68.7%, AUC 0.77), and clinical respiratory score ≥
6 (sensitivity 87.5%, specificity 96.9%, AUC 0.92). Conclusion: The
clinical respiratory score is the most accurate predictor of high flow
nasal cannula failure in pediatric patients. A clinical respiratory
score of more than 6, at 12 hours, is a helpful indicator for high flow
nasal cannula failure. pROX index, and the newly modified parameters in
this study are also good for prediction of high flow nasal cannula
failure Keyword: High flow nasal cannula, predictors, acute respiratory
distress children
Aquaculture industry prospective from gut microbiome of fish and shellfish: An overview
Authors: DIWAN ARVIND , harke Sanjay , Krishna Gopal , Panche Archana
Published: January 2024

The microbiome is a virgin science and, in recent years, has gained lot
of importance because of its pivotal role in the protection of human
health. The microbiome actually deals with microorganisms that are
associated with indigenous body parts and the entire gut system in all
animals, including human beings. These microbes are linked with roles
involving hereditary traits, defense against diseases, and strengthening
overall immunity, which determines the health status of an organism.
Considerable efforts have been made to find out the microbiome diversity
and their taxonomic identification in finfish and shellfish and its
importance has been correlated with various physiological functions and
activities. In recent-past due to the availability of advanced molecular
tools, some efforts have also been made on DNA sequencing of these
microbes to understand the environmental impact and other stress factors
on their genomic structural profile. There are reports on the use of
next-generation sequencing (NGS) technology, including amplicon and
shot-gun approaches, and associated bioinformatics tools to count and
classify commensal microbiome at the species level. The microbiome
present in the whole body, particularly in the gut systems of finfish
and shellfish, not only contributes to digestion but also has an impact
on nutrition, growth, reproduction, immune system and vulnerability of
the host fish to diseases. Therefore, the study of such microbial
communities is highly relevant for the development of new and innovative
bio-products which will be a vital source to build bio and
pharmaceutical industries, including aquaculture. In recent years,
attempts have been made to discover the chemical ingredients present in
these microbes in the form of biomolecules/bioactive compounds with
their functions and usefulness for various health benefits, particularly
for the treatment of different types of disorders in animals. Therefore,
it has been speculated that microbiomes hold great promise not only as a
cure for ailments but also as a preventive measure for the number of
infectious diseases. This kind of exploration of new breeds of microbes
with their miraculous ingredients will definitely help to accelerate the
development of the drugs, pharmaceutical and other biological related
industries. Probiotic research and bioinformatics skills will further
escalate these opportunities in the sector. In the present review,
efforts have been made to collect comprehensive information on the
finfish and shellfish microbiome, their diversity and functional
properties, relationship with diseases, health status, data on
species-specific metagenomics, probiotic research and bioinformatics
skills. Further, emphasis has also been made to carry out microbiome
research on priority basis not only to keep healthy environment of the
fish farming sector but also for the sustainable growth of biological
related industries, including aquaculture.
EFFECT OF FRESH FROZEN PLASMA AND CRYOPRECIPITATE IN MANAGING HYPODYSFIBRINOGENEMIA: A CASE REPORT
Authors: Sattoju Nithish , Maram Anvesh , Abbagoni Rishitha Sanjana , Ganapaka Sai Ram , Anneboina Vydhika
Published: January 2024

Management of multiple episodes of internal & external bleeding
associated with minimal injury in single patient diagnosed with
HYPODYSFIBRINOGENEMIA with Fresh Frozen Plasma transfusion &
CRYOPRECIPITATE transfusion is compared, which demonstrated that
CRYOPRECIPITATE transfusion can manage bleeding very effectively than
Fresh Frozen Plasma transfusion.
Optimal airway management in the treatment of descending necrotizing mediastinitis secondary to deep neck infection: Our experiences and review of literature
Authors: Kim Yoonho , Han Sungjun , Cho Deog Gon , Jung Won-Sang , Cho Jung-Hae
Published: January 2024

Objective: To review our experiences of descending necrotizing
mediastinitis (DNM) secondary to deep neck infection (DNI) and determine
appropriate airway management for decreasing mortality and morbidity of
patients with DNM. Study Design: A retrospective study Subjects and
Methods: Medical records of 20 patients (8 women and 12 men) who had
been managed for DNM secondary to DNI between March 2006 and December
2019 were analyzed. Diagnosis and extent of infection were confirmed by
computed tomography of the neck and chest. The upper airway was closely
monitored with a fiberoptic laryngoscope. Complications were evaluated
according to various types of airway management in our serial cases.
Results: Five (25 %) out of 20 patients died as a result of septic
shock and multi-organ failure. None of these patients died from
accidental airway obstruction or airway management mishaps. Keeping
short-term orotracheal intubation was safe and adequate after the
initial surgery. Early tracheotomy was performed for four patients of
all but it was significantly associated with mortality (p=0.032). Three
patients who underwent late tracheotomy had no mortality. Patients with
tracheotomy had longer duration of overall hospital stay than those
without tracheotomy. Conclusions. Well-controlled airway management
might decrease mortality, hospitalization, and airway complications in
patients with DNM secondary to DNI. Keeping orotracheal intubation
rather than upfront tracheotomy should be first considered when managing
airway along with examination of the upper airway with a fiberoptic
laryngoscope.
The effects of number and quality of transferred blastocysts and female age on pregnancy outcomes in frozen-thawed cycles: a retrospective study
Authors: Li Yuhu , zhang liuguang , Cai Xuexiang , LI Ning , Ma Bo
Published: January 2024

Abstract Objective To evaluate the effects of number and quality of
transferred blastocysts and female age on pregnancy outcomes. Design A
retrospective study. Setting Two IVF centers. Population Women
undergoing first blastocyst transfer in frozen-thawed cycles. Methods
6096 frozen-thawed blastocyst transfer cycles were divided into five
groups based on blastocyst number and quality and three groups according
to female age. Main Outcome Measures Implantation rate (IR), clinical
pregnancy rate (CPR), multiple pregnancy rate (MPR), live birth rate
(LBR) and neonatal characteristics. Results Female age, quality and
number of transferred blastocysts had significant effects on pregnancy
outcomes. IR, CPR and LBR of the same blastocyst transfer groups
decreased gradually with age. Increasing the transferred number of same
grade blastocysts did not obviously increase CPR and LBR, however, it
significantly increased MPR. For double blastocyst transfer, the
better-quality the transferred blastocysts were, the higher the IR, CPR,
MPR and LBR were. Singleton group had the best neonatal characteristics
followed by dizygotic twins and monozygotic twins. There was a positive
correlation between sex ratio and the proportion of good-quality
blastocysts, and the difference was significant between good-quality and
poor-quality blastocyst groups (1.35 vs 0.98, P/CI = 0.002/1.123-1.687).
Conclusions Selective single good-quality blastocyst transfer may serve
as an effective embryo transfer strategy to reduce MPR while maintaining
LBR and obtain good pregnancy outcomes, but, the strategy may result in
an unbalanced sex ratio of newborns. Funding None. Keywords: Blastocyst
transfer, age, multiple pregnancy, live birth rate, neonatal
characteristics.
Catheter Ablation of Atrial Fibrillation in Patients with Cor Triatriatum Sinister; A Case Series and Review of the Literature
Authors: Karimianpour Ahmadreza , Cai Amanda , Cuoco Frank , Sturdivant John , Litwin Sheldon , Wharton J. Marcus
Published: January 2024

Introduction: Cor triatriatum sinister (CTS) is a rare congenital heart
defect associated with atrial fibrillation (AF). The incidence of
hemodynamically insignificant CTS in the AF ablation population and its
effect on ablation success are not known. Furthermore, little is known
about the potential effect of CTS on arrhythmogenic substrate.
Objective: We define the incidence of hemodynamically insignificant CTS
in patients undergoing AF ablation with RF and cryoballoon ablation, the
technical challenges created by the left atrial partitioning, and the
potentially arrhythmogenic effects of the membrane. Methods: First-time
AF ablation cases at our institution over a 10-year period were screened
to identify and describe patients with CTS. Additionally, a
PubMed/MEDLINE search was performed for a review of literature on
patients with CTS undergoing CA of AF. Results: Of the 3,953 consecutive
patients undergoing initial AF ablation during the study period, four
patients (0.10%) had CTS. Ablation was successful acutely in all
patients. One patient had recurrent AF and required repeat ablation for
a single procedure success rate of 75% and multi-procedure success rate
of 100%. The CTS membrane was associated with low voltage zones in the
two patients in whom it was measured and with substrate for
macro-reentrant atrial tachycardia in one of these patients. Conclusion:
The incidence of hemodynamically insignificant CTS in patients
undergoing CA for AF is very low, but does not serve as a significant
barrier to successful ablation as long as pulmonary vein access is
approached by directed access to the superoposterior chamber.
The Role of Fertilizers of the Cell Wall Changing of the Kenaf Fibers
Authors: Salih Rabar
Published: January 2024

Two field tests done in 2013 and 2014 on two kenaf varieties: Fuhong-952
and 4383 at Universiti Putra Malaysia which was to investigate the
fertilizers effect of the protein content in the cell wall of the
fibers. Potassium as muriate of potash at the rate of 0, 100 and 150
kg/ha, was added to the plants which was in two different stages of
plant age, in each stage added halve dose at planting day and after
planting by three weeks. Boron and zinc were also added to the plants,
while the second time of potassium application (0, 1.0, 1.5 and 0, 5.0
kg/ha, of borax and zinc chloride), respectively. Besides that, during
the second field test FH-952 was selected with applying the highest
level of potassium 150 kg/ha, additionally other levels of zinc were
added to display its impact of quality properties. The best result of
protein content was achieved for FH-952 when potassium was added at the
high level, nevertheless 4383 was when potassium, boron and zinc were
applied at the rate of 150, 1.0 and 5.0 kg/ha, respectively. During the
second experiment zinc performances caused to achieve tough fibers which
was possible for using as biocomposite materials.
Light-driven oxygenase-based whole-cell biocatalysis in cyanobacteria
Authors: Liu Yi
Published: January 2024

Baeyer–Villiger monooxygenases (BVMOs) can be used for the biosynthesis
of ε-Caprolactone by oxidizing cyclohexanone. However, the external
supply of co-substrate O2 and redox cofactor NADPH is uneconomical.
Thereby, photosynthesis, which can synthesis O2 and NADPH, can be
exploited and integrated with oxygenase-based whole-cell biocatalysis.
Ex Utero Intrapartum Treatment Procedure for Congenital Cervical Germ Cell Tumor with Gliomatosis
Authors: Quinn Kirby , Gilna Gareth , Chamyan Gabriel , Tirado Yamilet , Carrillo Adriana , Khatib Ziad , Fernandez-Castro Claudia , Reyes Clara , Brady Ann , Hogan Anthony , Thorson Chad
Published: January 2024

Congenital cervical germ cell tumors are a rare location for
extragonadal germ cell tumors that may lead to acute airway obstruction.
We present the unique case and successful resection of an immature
cervical teratoma. Urgent Ex Utero Intrapartum Treatment (EXIT)
procedure was performed via Cesarean section with subsequent
endotracheal intubation to maintain the airway. Successful surgical
resection of the mass at day six of life was performed showing
histologically immature teratoma along with gliomatosis in surrounding
lymph node tissue. The patient recovered well with no abnormalities on
follow up at 14 months.
Malignant Extrarenal Rhabdoid Tumor of the Heart in an Infant: Case Report and Literature Review
Authors: Marrero Minelys Alicea , Guruchandrasekar Sanchitha , Español María , Powell Shannon , Venkatramani Rajkumar , LeBlanc Zachary
Published: January 2024

Malignant extrarenal rhabdoid tumors (MERT) are aggressive malignancies
of infancy with dismal prognosis; cardiac localization is extremely
rare. A 5-month-old male was diagnosed with a cardiac MERT after finding
a large heterogenous mass attached to the left ventricular wall. He
responded well to initial intensive chemotherapy but developed tumor
progression 4 months after diagnosis. Palliative treatment with
ipilimumab and nivolumab was administered; however, he died within one
week. New treatment options are essential to improve survival in
patients where complete tumor resection is unattainable.
PRE-HEART FAILURE IN THE LIGHT OF 2D AND 3D SPECKLE TRACKING ECHOCARDIOGRAPHY: A COMPREHENSIVE REVIEW
Authors: SINGH R.B , Elkilany Galal , Fedacko Jan , Sozzi Fabiola , Hristova Krasimira , Fatima Ghizal , Pella Daniel , Cornelissen Germaine , Isaza Adrian , Pella Dominik , Singh Jaipaul , Carugo Stefano , Nanda Navin C.
Published: January 2024

Chronic heart failure (CHF) has different stages and they include pre-HF
(PHF), a state of high risk of developing myocardial dysfunction and
subsequently, advanced CHF (ACHF). Some major behavioral risk factors of
PHF are Western diet, tobacco, alcoholism, sedentary life style and
chronic mental disorders (anxiety, depression). These insults might
predispose to biological risk factors such as obesity, diabetes mellitus
dyslipidemia hypertension, myocardial infarction and cardiomyopathy.
These risk factors damage the myocytes leading to fibrosis, apoptosis,
cardiac hypertrophy, along with alterations in cardiomyocyte’ size and
shape. A condition of physiological subcellular remodeling resulting
into a pathological or deformation state might be developed conductiong
to PHF. Both PHF and HF are associated with the activation of
phospholipases and protease, mitochondrial dysfunction, oxidative stress
and development of intracellular free Ca2+ [Ca2+]i overloading or an
elevation in diastolic [Ca2+]i. Simultaneously, cardiac gene
expression is activated leading to further molecular, structural and
biochemical changes of the myocardium. The sub-cellular remodeling may
be intimately involved in the transition of cardiac hypertrophy to heart
failure. Two-dimensional (2D) and three-dimensional (3D) speckle
tracking-echocardiography (STE) have been used to quantify regional
alterations of longitudinal strain and area strain, through their polar
projection, which permits a further assessment of both sites and degrees
of myocardial damage. The examination of strain can identify
sub-clinical cardiac dysfunction or cardiomyocyte remodeling. It is
concluded that during remodeling of the myocardium, cardiac strain is
attenuated which can be used for the assessment of disease progression
and subsequently for therapeutic interventions.
Identification of a novel NRG1 fusion with targeted therapeutic implications in locally advanced pediatric cholangiocarcinoma
Authors: Mitchell Sarah , Basu Gargi , Goodman Laurie , Goldsmith Kelly
Published: January 2024

Locally advanced cholangiocarcinoma has a poor prognosis, with long-term
survival observed only in patients where complete surgical resection is
achieved. Pediatric cholangiocarcinoma is exceedingly rare, with an
estimated 15-22 cases reported in the last 40 years. As such, no
standard therapeutic regimen exists. Novel strategies combining
conventional chemotherapy and radiotherapy followed by targeted agents
can lead to durable treatment responses and are applicable to pediatric
cholangiocarcinoma management. We present a case of a 17-year-old
patient with unresectable cholangiocarcinoma whose tumor genetic
sequencing revealed a novel, actionable NRG1 translocation, providing an
opportunity to utilize combination treatment in the pediatric setting.
Emergency Chest Ultrasound and Traumatic Pneumothorax. An Updated Meta-Analysis
Authors: Zhou Yu , Tian Haiyan , Zhang Ton , Rastogi Sanjay , Choudhury Rupshikha
Published: January 2024

Aims: A commonly encountered problem in emergency care is pneumothorax,
identified by air present in pleural space, occurring spontaneously,
principally because of trauma or pathogenic factors like a central
venous catheter, mechanical ventilation, and biopsy. Employing Chest
ultrasound for diagnosing pneumothorax in an emergency is currently
investigated by many researchers. The present meta-analysis aimed to
assess Chest ultrasound’s diagnostic accuracy in diagnosing the
pneumothorax during emergencies. Material and Methods: Literature search
of published articles in MEDLINE, Embase, Ovid, Scopus, and Journal on
web databases from 2000 up to November 2020 were reviewed for the
pre-described outcomes. Results: 12 articles were finally chosen for
quantitative analysis. The overall sensitivity of ultrasound scan in
pneumothorax diagnosis was 89% (95 % CI – 86 – 91%). Specificity
was 96% (CI – 95% – 97%). The diagnostic odds ratio was 193.94
(59.009 – 637.40) at 95% CI, thus demonstrating greater chest
ultrasound accuracy in diagnosing pneumothorax. Conclusion: A definite
evidence of chest ultrasound accuracy was noted in pneumothorax.
Autologous cryopreserved decellularized glutaraldehyde-treated human pericardium for redo aortic valve repair
Authors: Abdurakhmanov Zufar , Yemets Illya
Published: January 2024

In the past decade, aortic valve (AV) repair in children with cusp
prolapse has comprised cusp plication, triangular resection and then
extension with autopericardium. Although these techniques have been
quite reproducible, durability of AV repair (AVRep) in children with a
lack of valve tissue, has been challenging with the mean time to a 50%
reoperation of 4,4 years (1). In this setting, cusp replacement may
occasionally be quite beneficial to allow for aortic root growth and
postponement AV replacement (AVR) methods can be safely used precluding
their drawbacks for a time (2). We report a successful application of
redo cusp replacement to pediatric patient applying cryopreserved
decellularized glutaraldehyde-treated (CDGT) autopericardium.
EFFECTIVENESS OF HYDROGEN PEROXIDE CONCENTRATIONS ON BLEACHING AND TOOTH SENSITIVITY - A SYSTEMATIC REVIEW
Authors: GOUSALYA V , D Prabu , M Rajmohan , M DINESH DAMODHAR , VV Bharathwaj , R SINDHU , S SHREELAKSHMI
Published: January 2024

ABSTRACT Objective: In this study, the literature was systematically
reviewed to investigate the effect of hydrogen peroxide concentrations
on bleaching effect and tooth sensitivity. Data Sources: Electronic
databases were screened, and hand searched. Searched electronic
databases are PubMed, Scopus, Cochrane Library, Ovid Medline, Elsevier
science direct, Wiley online library, Grey literature, Embase. Materials
and Methods: A systematic review on controlled clinical trials MeSH
terms used are (hydrogen peroxide) AND (bleaching) AND (tooth
sensitivity). A trial on the bleaching effect and tooth sensitivity with
various hydrogen peroxide concentrations were included. PRISMA
guidelines were followed, and the PICO model was used. Cochrane risk
assessment tool for randomized controlled trials was used. Results: A
total of 5 articles fulfilled the inclusion criteria. The analysis
showed that high hydrogen peroxide concentration has a better bleaching
effect accompanied by tooth sensitivity. Low hydrogen peroxide
concentration also has a bleaching effect slightly minimal from the
former, followed by less tooth sensitivity. Conclusion: This study
concludes that the hydrogen peroxide with higher concentration is
effective in bleaching and with lower concentration is less likely to
produce tooth sensitivity KEYWORDS: h2o2, bleaching, sensitivity, tooth
shade, aesthetic dentistry
Using machine learning to characterize the impact of oseltamivir on clinical failure in hospitalized patients with lower respiratory tract infection
Authors: Wiemken Timothy , Furmanek Stephen , Carrico Ruth , Peyrani Paula , Hoft Daniel , Fry Alicia , Ramirez Julio
Published: January 2024

We used causal forest machine learning to re-analyze data from a
randomized study evaluating oseltamivir in hospitalized patients with
lower respiratory tract infection. Influenza virus infected patients had
26% lower risk of clinical failure when treated with oseltamivir (95%
CI 3.2% - 48.0%), suggesting it may be a useful intervention.