bluuebunny/crossref_metadata_2025 huggingface dataset:
Treatment of Vulvovaginal Candidiasis—An Overview of Guidelines and the Latest Treatment Methods
Authors: Satora Małgorzata , Grunwald Arkadiusz , Zaremba Bartłomiej , Frankowska Karolina , Żak Klaudia , Tarkowski Rafał , Kułak Krzysztof
Published: August 2023

Vulvovaginal candidiasis (VVC) is a common condition associated with discomfort in affected women. Due to the presence of different forms of the disease, diverse treatment regimens are developed; the newest ones include oteseconazole and ibrexafungerp. Here, we focus on the most up-to-date recommendations regarding VVC treatment, as well as novel treatment options. Topical and oral azoles are the drugs of choice in uncomplicated mycosis. The efficacy of probiotics and substances such as TOL-463 and chlorhexidine is indicated as satisfactory; however, there are no relevant guidelines. Although the majority of researchers agree that the treatment of non-albicans VVC should be long-lasting, the recommendations are inconsistent. Another clinical problem is the treatment of VVC with azole intolerance or resistance, for which literature proposes the use of several drugs including oteseconazole, ibrexafungerp, and voriconazole. The treatment schedules for recurrent VVC include mainly fluconazole; however, alternative options such as immunotherapeutic vaccine (NDV-3A) or designed antimicrobial peptides (dAMPs) were also described. We also focused on VVC affecting pregnant women, which is a substantial challenge in clinical practice, also due to the heterogeneous relevant guidelines. Thus far, few precise recommendations are available in the literature. Future studies should focus on atypical VVC forms to elucidate the inconsistent findings.
Intracardiac Thrombi in Morbus Adamantiades–Behçet in Two Swedish Patients
Authors: Da Mutten Raffaele , Borg Alexander , Chatzidionysiou Katerina , Parodis Ioannis
Published: August 2023

Morbus Adamantiades–Behçet (MAB) is an inflammatory disease typically manifesting with oral and genital aphthosis, erythema nodosum, and vasculopathy, and in only around 2%, cardiac involvement. Its prevalence is usually higher along the historic Silk Road, but rarer in Scandinavia where 0.64–4.9 in 100,000 people are affected. We herein present two Swedish patients with cardiac manifestations of Morbus Adamantiades–Behçet. Along with the intracardial thrombi, which both patients presented with, one patient also had cerebrovascular insults leading to visual field deficits as well as involvement of peripheral nerves. Being of Scandinavian origin and showing uncommon symptoms as their initial manifestations of MAB, the 62- and 35-year-old patients presenting herein constitute rare cases.
Is the Pattern Changing? Atrial Fibrillation and Screening with Holter Electrocardiograms among Ischemic Stroke Patients in Greenland from 2016 to 2021
Authors: Albertsen Nadja , Hansen Anne Sofie , Skovgaard Nils , Pedersen Michael Lynge , Andersen Stig , Riahi Sam
Published: August 2023

A standardized examination regime for ischemic stroke (IS) patients was implemented in Greenland in 2010. Prevalence of atrial fibrillation (AF) of 32% was found among discharged IS patients from 2011 to 2012, and our study aims to estimate the use of Holter ECGs for AF diagnostics and the current prevalence of AF among IS patients in Greenland. Patients discharged from Queen Ingrid’s Hospital in Nuuk between 2016 and 2021 with an ICD-10 diagnosis of IS or stroke without specification were included. Data on Holter recordings, age, gender, medical treatment with rivaroxaban or warfarin, and ICD-10 and ICPC codes for AF were extracted for each patient. The overall incidence of IS from 2016 to 2021 was 133/100,000 and unchanged since 2012. Sixty-eight of the study’s IS patients (14.5%) had AF, and 46% of IS patients with Holter data accessible had a recording according to international recommendations. Our results indicate that fewer IS patients in Greenland have AF than previously. However, the insufficient use of Holter as a diagnostic tool may explain part of the drop, as well as improved preventive treatment with rivaroxaban among AF patients in Greenland. Regardless, IS remains common, and a focus on diagnostics and preventable risk factors should be maintained.
Depression and Anxiety in Association with Polypharmacy in Patients with Multiple Sclerosis
Authors: Baldt Julia , Frahm Niklas , Hecker Michael , Streckenbach Barbara , Langhorst Silvan Elias , Mashhadiakbar Pegah , Burian Katja , Meißner Janina , Heidler Felicita , Richter Jörg , Zettl Uwe Klaus
Published: August 2023

Polypharmacy (intake of ≥5 drugs) is an important issue for patients with chronic diseases such as multiple sclerosis (MS). We aimed to assess the prevalence of polypharmacy with regard to the severity of anxiety/depression and to comorbidities. Therefore, 374 MS patients from two German neurological sites were examined for drug burden, comorbidities, disability level and psychopathological measures capturing depression and anxiety using the Hospital Anxiety and Depression Scale (HADS-A and HADS-D). We found that patients with a higher HADS-D score take more medication (r = 0.217, p < 0.001). Furthermore, patients with higher depression severity were more likely to show polypharmacy (p < 0.001). These differences were not significant for anxiety. (p = 0.413). Regarding the frequency of ≥1 comorbidities, there were no significant differences between patients with different HADS-A (p = 0.375) or HADS-D (p = 0.860) severity levels, whereas the concrete number of comorbidities showed a significant positive linear correlation with HADS-A (r = 0.10, p = 0.045) and HADS-D scores (r = 0.19, p < 0.001). In conclusion, symptoms of depression pose a relevant issue for MS patients and are correlated with polypharmacy and comorbidities. Anxiety is not correlated with polypharmacy but with the frequency of several comorbidity groups in MS patients.
Long-Term Outcomes in Thoracic Endovascular Aortic Repair for Complicated Type B Aortic Dissection or Intramural Hematoma Depending on Proximal Landing Zone
Authors: Dueppers Philip , Meuli Lorenz , Stoklasa Kerstin , Menges Anna-Leonie , Zimmermann Alexander , Reutersberg Benedikt
Published: August 2023

Thoracic endovascular aortic repair (TEVAR) is the preferred treatment for complicated type B aortic dissection (TBAD) or intramural hematoma (IMH). This study aimed to investigate the association of the proximal landing zone and its morphology with long-term outcomes in patients with TBAD or IMH. A total of 94 patients who underwent TEVAR for TBAD or IMH between 10/2003 and 01/2020 were included. The cohort was divided according to the proximal landing in Ishimaru zone 2 or 3 and the presence of a healthy landing zone (HLZ; non-dissected or aneurysmatic, ≥2 cm length). Primary outcome was freedom from aortic reintervention. Secondary endpoints were freedom from aortic growth, stroke, spinal cord ischemia, retrograde dissection, proximal stent-graft induced new entry (pSINE), debranching failure, and mortality. Outcomes were assessed using Cox proportional hazard models with mortality as a competing risk. A proximal TEVAR landing in zone 2 was associated with higher rates of reinterventions compared to zone 3 (33% vs. 15%, p = 0.031), spinal cord ischemia (8% vs. 0%, p = 0.037), and pSINE (13% vs. 2%, p = 0.032). No difference was found for the other outcomes, including mortality. Landing in dissected segments was not associated with impaired results. Proximal TEVAR landing in zone 3 may be preferable with regard to long-term aortic reintervention in patients with TBAD or IMH.
Gelatin-Based Hydrogels Containing Microcrystalline and Nanocrystalline Cellulose as Moisture Absorbers for Food Packaging Applications
Authors: Acevedo-Puello Vanessa , Figueroa-López Kelly J. , Ortega-Toro Rodrigo
Published: August 2023

Sustainable hydrogels are an innovative biodegradable alternative to traditional packaging materials. They offer exceptional water absorption capacity and high biocompatibility, making them ideal food absorbents to reduce plastic waste, extend shelf life and ensure the safety and quality of packaged foods. In this study, hydrogels based on gelatin, microcrystalline cellulose (MCC), and nanocrystalline cellulose (NCC) were developed, characterized, and applied in the packaging of chicken breasts. For this, MCC was isolated from the banana pseudostem and commercial NCC was incorporated into a gelatin solution to produce the hydrogel materials by film casting. The resulting hydrogels were analyzed in terms of morphology, structural properties, water absorption capacity, mechanical strength, and color properties. The results showed that the incorporation of MCC and NCC significantly improved the mechanical integrity of the hydrogels, which prevented premature deformation of the hydrogels when they absorbed moisture. In addition, changes in the color properties of chicken breast samples in contact with the hydrogels were observed, indicating their ability to preserve food quality. Subsequently, the effectiveness of the hydrogels for chicken breast storage at 4 °C for 4 days was validated. The results demonstrated that the hydrogels developed in this study are a sustainable and environmentally friendly alternative to traditional packaging materials that can extend the shelf life of food products while maintaining their physical and microbiological integrity.
Recent Advances on The Applications of Phase Change Materials in Cold Thermal Energy Storage: A Critical Review
Authors: Rashid Farhan Lafta , Al-Obaidi Mudhar A. , Dulaimi Anmar , Bernardo Luís Filipe Almeida , Redha Zeina Ali Abdul , Hoshi Hisham A. , Mahood Hameed B. , Hashim Ahmed
Published: August 2023

Cold thermal energy storage (CTES) based on phase change materials (PCMs) has shown great promise in numerous energy-related applications. Due to its high energy storage density, CTES is able to balance the existing energy supply and demand imbalance. Given the rapidly growing demand for cold energy, the storage of hot and cold energy is emerging as a particularly attractive option. The main purpose of this study is to provide a comprehensive overview of the current research progress on the utilisation of PCMs in CTES. The greatest difficulties associated with using PCMs for CTES are also examined in this overview. In this regard, a critical evaluation of experimental and numerical studies of the heat transfer properties of various fundamental fluids using PCMs is conducted. Specifically, several aspects that affect the thermal conductivity of PCMs are investigated. These factors include nanoparticle-rich PCM, a form of encapsulated PCM, solids volume percentage, and particle size. Discussions focus on observations and conclusions are drawn from conducted studies on PCMs used in CTES. Based on the findings of this study, a set of plausible recommendations are made for future research initiatives.
Book Review: Melbourne, S. Refining Nature: The Landscape Architecture of Peter Walker, 2nd ed.; Birkhäuser: Basel, Switzerland, 2022; ISBN: 978-3-0356-2548-6
Authors: Dehghanifarsani Laleh , Khalilnezhad Mohammad Reza , Amani-Beni Majid
Published: August 2023

Throughout the historical development of built landscape design, the process of creating and shaping landscape structures has demanded extensive expertise, creativity, and a profound comprehension of landscape design history [...]
Quantitative Evaluation of the Impact of Vegetation Restoration and Climate Variation on Runoff Attenuation in the Luan River Basin Based on the Extended Budyko Model
Authors: Yue Shuaijun , Huang Junchang , Zhang Yali , Chen Weiqiang , Guo Yulong , Cheng Mingyue , Ji Guangxing
Published: August 2023

The occurrence of water scarcity and extreme hydrological events is becoming increasingly frequent worldwide. The river runoff process, as an important link in the water cycle of a basin, is an essential content of the study of hydrological processes in the basin. Vegetation is an influencing factor closely related to hydrological processes in a watershed. This article quantitatively analyzes the impact of vegetation restoration and climate variation on runoff in the Luan River Basin from 1982 to 2018. Firstly, trend analysis was conducted on runoff depth, precipitation, the Normalized Vegetation Index (NDVI), and reference evaporation. Then, Mann–Kendall mutation analysis and Pettitt mutation analysis were used to identify the year of runoff mutation. Finally, a Budyko model was constructed to quantitatively analyze the impact of vegetation and climate change on the runoff of the Luan River. The results showed that: (1) The runoff reduction rate of the Luan River was 1.2437 mm/a. The precipitation was increasing at a rate of 0.6977 mm/a. The reference evaporation rate decreased at a rate of 0.0977 mm/a. The annual growth rate of the Budyko parameter (n) was 0.0283. The annual growth rate of NDVI was 0.0022. (2) The coefficient of determination in the functional equation (a = 14.74, b = −3.4105) for NDVI and Budyko parameter (n) was 0.3297 (p < 0.01). (3) The contributions of Pr, ET0, NDVI, and (n) to reduced flow were −17.49%, 1.46%, 35.25%, and 80.78%, respectively. The increase in vegetation would lead to a decrease in runoff. This study can clarify the impact of vegetation restoration on water resource security in the Luan River Basin.
Short-Term Effect of Different Inputs of Organic Amendments from Olive Oil Industry By-Products on Soil Organic Carbon and Physical Properties
Authors: Vignozzi Nadia , Andrenelli Maria Costanza , Agnelli Alessandro Elio , Fiore Angelo , Pellegrini Sergio
Published: August 2023

Maintaining adequate levels of soil organic matter in Mediterranean agro-ecosystems is a pressing need due to the increasing evidence of climate change. The use of by-products of the olive oil industry as organic amendments could contribute to this goal. We report the results of a 2-year research carried out in southern Italy on a clay loam soil for evaluating the effects of different olive oil industry by-products on soil organic carbon and other related soil characteristics. The treatments were: (i) Olive mill wastewater (OMW), (ii) compost from olive pomace (CP1), (iii) compost from olive pomace in double quantity (CP2), and (iv) organo-mineral fertilizer (OMF). Soil samples, collected at a depth of 0–20 cm, were analyzed for total organic carbon (TOC), its extractable (TEC) and humic fractions (HC), and aggregate stability (Ist). In addition, soil macroporosity, water retention, and penetration resistance (PR) were evaluated. CP1 induced the largest increase in soil TOC, TEC, and HC content, and a significant improvement in Ist; the addition of a large quantity of organic carbon (CP2) did not determine a proportional increase in soil organic matter content. The aggregate stability of the CP2 was the lowest; nevertheless, the characterization of macroporosity indicated an improvement of soil structure functionality. With respect to control (OMF), OMW had a significant decrease in Ist and an increase in PR of the uppermost soil layer.
An Examination of the Role of Perpetrator’s Relationship to Overall School Shooting Casualties
Authors: Joseph Justin J. , Purser Christoper W.
Published: August 2023

High-profile school shootings in recent years have fueled fear and uncertainty among stakeholders (e.g., parents, teachers, and students) and the public debate on gun control legislation nationwide. These fears are reflected in the public discourse and the academic community, which focuses their investigation on rampage school shootings. To address this gap in the empirical literature, the current study’s goal is twofold: (1) to contribute to the descriptive understanding of school shooting characteristics; and (2) address the gaps in the extant literature through examining the perpetrators relationship with the school on the total number of victims during a school shooting incident. Secondary data analysis was performed on the K-12 School Shooting database (K-12 SSDB). A negative binomial and descriptive analysis were conducted on the K-12 School Shooting database, established by the Naval Postgraduate School’s Center for Homeland Defense and Security (CHDS) in 2018, which has been recently updated to reflect recent incidents. The findings and policy implications of the findings are discussed in detail in the manuscript.
The Underrated Gut Microbiota Helminths, Bacteriophages, Fungi, and Archaea
Authors: Garcia-Bonete Maria Jose , Rajan Anandi , Suriano Francesco , Layunta Elena
Published: August 2023

The microbiota inhabits the gastrointestinal tract, providing essential capacities to the host. The microbiota is a crucial factor in intestinal health and regulates intestinal physiology. However, microbiota disturbances, named dysbiosis, can disrupt intestinal homeostasis, leading to the development of diseases. Classically, the microbiota has been referred to as bacteria, though other organisms form this complex group, including viruses, archaea, and eukaryotes such as fungi and protozoa. This review aims to clarify the role of helminths, bacteriophages, fungi, and archaea in intestinal homeostasis and diseases, their interaction with bacteria, and their use as therapeutic targets in intestinal maladies.
Inpatient Rehabilitation Outcomes after Primary Severe Haemorrhagic Stroke: A Retrospective Study Comparing Surgical versus Non-Surgical Management
Authors: Ong Poo Lee , Seah Justin Desheng , Chua Karen Sui Geok
Published: August 2023

Background: Haemorrhagic stroke, accounting for 10–20% of all strokes, often requires decompressive surgery as a life-saving measure for cases with massive oedema and raised intracranial pressure. This study was conducted to compare the demographics, characteristics and rehabilitation profiles of patients with severe haemorrhagic stroke who were managed surgically versus those who were managed non-surgically. Methods: A single-centre retrospective study of electronic medical records was conducted over a 3-year period from 1 January 2018 to 31 December 2020. The inclusion criteria were first haemorrhagic stroke, age of >18 years and an admission Functional Independence Measure (FIM™) score of 18–40 upon admission to the rehabilitation centre. The primary outcome measure was discharge FIM™. Secondary outcome measures included modified Rankin Scale (mRS), rehabilitation length of stay (RLOS) and complication rates. Results: A total of 107 patients’ records were analysed; 45 (42.1%) received surgical intervention and 62 (57.9%) patients underwent non-surgical management. Surgically managed patients were significantly younger than non-surgical patients, with a mean age of [surgical 53.1 (SD 12) vs. non-surgical 61.6 (SD 12.3), p = 0.001]. Admission FIM was significantly lower in the surgical vs. non-surgical group [23.7 (SD6.7) vs. 26.71 (SD 7.4), p = 0.031). However, discharge FIM was similar between both groups [surgical 53.91 (SD23.0) vs. non-surgical 57.0 (SD23.6), p = 0.625). Similarly, FIM gain (surgical 30.1 (SD 21.1) vs. non-surgical 30.3 (SD 21.1), p = 0.094) and RLOS [surgical 56.2 days (SD 21.5) vs. non-surgical 52.0 days (SD 23.4), p = 0.134) were not significantly different between groups. The majority of patients were discharged home (surgical 73.3% vs. non-surgical 74.2%, p = 0.920) despite a high level of dependency. Conclusions: Our findings suggest that patients with surgically managed haemorrhagic stroke, while older and more dependent on admission to rehabilitation, achieved comparable FIM gains, discharge FIM and discharge home rates after ~8 weeks of rehabilitation. This highlights the importance of rehabilitation, especially for surgically managed haemorrhagic stroke patients.
Thermoregulation in Two Models of Trail Run Socks with Different Fabric Separation
Authors: Moran-Cortes Juan Francisco , Gómez-Martín Beatriz , Escamilla-Martínez Elena , Sánchez-Rodríguez Raquel , Gómez-Carrión Álvaro , Martínez-Nova Alfonso
Published: August 2023

Background: Trail running socks with the same fibers and design but with different separations of their three-dimensional waves could have different thermoregulatory effects. Therefore, the objective of this study was to evaluate the temperatures reflected on the sole of the foot after a mountain race with the use of two models of socks with different wave separations. Material and Methods: In a sample of 34 subjects (twenty-seven men and seven women), the plantar temperature was analyzed with the thermal imaging camera Flir E60bx® (Flir systems, Wilsonville, OR, USA) before and after running 14 km in mountainous terrain at a hot temperature of 27 °C. Each group of 17 runners ran with a different model of separation between the waves of the tissue (2 mm versus 1 mm). After conducting the post-exercise thermographic analysis, a Likert-type survey was conducted to evaluate the physiological characteristics of both types of socks. Results: There was a significant increase in temperature in all areas of interest (p < 0.001) after a 14 km running distance with the two models of socks. The hallux zone increased in temperature the most after the race, with temperatures of 8.19 ± 3.1 °C and 7.46 ± 2.1 °C for the AWC 2.2 and AWC 3, respectively. However, no significant differences in temperature increases were found in any of the areas analyzed between the two groups. Runners perceived significant differences in thermal sensation between AWC 2.2 socks with 4.41 ± 0.62 points and AWC 3 with 3.76 ± 1.03 points (p = 0.034). Conclusion: Both models had a similar thermoregulatory effect on the soles of the feet, so they can be used interchangeably in short-distance mountain races. The perceived sensation of increased thermal comfort does not correspond to the temperature data.
Takotsubo Cardiomyopathy Occurring Simultaneously with Acute Myocardial Infarction
Authors: Srdanović Ilija , Dabović Dragana , Ivanović Vladimir , Čanković Milenko , Pantić Teodora , Stefanović Maja , Dimić Sonja , Crnomarković Branislav , Bjelobrk Marija , Govedarica Miljana , Zdravković Marija
Published: August 2023

Introduction: Takotsubo cardiomyopathy (TCM) is a reversible form of cardiomyopathy characterized by transient regional systolic dysfunction of the left ventricle. Case outline: A 78-year-old woman was admitted to the general hospital due to acute inferior STEMI late presentation. Two days after admission, the patient reported intense chest pain and an ECG registered diffuse ST-segment elevation in all leads with ST-segment denivelation in aVR. The patient also showed clinical signs of cardiogenic shock and was referred to a reference institution for further evaluation. Echocardiography revealed akinesia of all medioapical segments, dynamic obstruction of the left ventricular outflow tract (LVOT), moderate mitral regurgitation, and pericardial effusion. Coronary angiography showed the suboccluded right coronary artery, and a primary percutaneous coronary intervention was performed, which involved implanting a drug-eluting stent. The patient’s condition worsened as pericardial effusion increased and led to tamponade. Pericardiocentesis was performed, resulting in the patient’s stabilization. At this point, significant gradients at the LVOT and pericardial effusion were not registered. After eight days without symptoms and stable status, the patient was discharged. Conclusions: The simultaneous presence of AMI and TCM increases the risk of developing cardiogenic shock. The cardio-circulatory profile of these patients is different from those with AMI.
Surface Treatments for Enhancing the Bonding Strength of Aluminum Alloy Joints
Authors: Luo Juncheng , Liu Jianhua , Xia Huanxiong , Ao Xiaohui , Yin Haojie , Guo Lei
Published: August 2023

Aluminum alloy adhesive bonding joint widely appears in many industrial products. Improving the mechanical performances of aluminum alloy bonding joints has been attracting much effort. To acquire more excellent bonding strength, this paper focused on the effects of different surface treatments, including laser ablation and milling superposed by phosphoric acid anodizing (PAA). The treated surfaces were characterized by roughness and contact angle, and the effects of the geometric parameters of microstructures on wettability, failure mode, and shear strength were examined. The results indicate that those surfaces where the spacing is smaller than the diameter present a hydrophilic property and the corresponding specimens are mainly subject to cohesive failure, and vice versa. Additionally, laser ablation with a properly designed dimple pattern can greatly improve the bonding strength, and the maximum average shear strength of specimens with a thickness of 50 μm reaches 32.82 MPa, which is an increase of 28.15% compared with the original milling specimen. Moreover, fabricating groove or grid patterns on the surfaces and applying PAA treatment can also significantly enhance the bonding strength, reaching up to 36.28 MPa.
Preparation of Self-Coating Al2O3 Bonded SiAlON Porous Ceramics Using Aluminum Dross and Silicon Solid Waste under Ambient Air Atmosphere
Authors: Liu Zhaoyang , Wang Junyang , Zhao Zixu , Yang Qiuyu , Qin Lihang , Zhang Kaichen , Wang Xiangnan , Su Nan , Wen Tianpeng , Yuan Lei , Yu Jingkun
Published: August 2023

Al2O3-bonded SiAlON ceramic with self-coating was prepared using aluminum dross and silicon solid waste as starting materials under ambient air conditions. The changes in phase, microstructure, and physical properties of the ceramic with temperature were analyzed and the formation mechanism of the SiAlON phase was elucidated. The results showed that higher temperature was more suitable for the preparation of SiAlON ceramics. As the temperature increased from 1400 to 1600 °C, the main phases in the ceramic transformed from mullite, Al2O3, and SiAlON to Al2O3 and SiAlON. An Al2O3-rich layer spontaneously coated the surface of the porous ceramic as Al melted and oxidized at high temperature. The thickness of this layer decreased as the temperature increased. The presence of Al2O3-rich coating layer impeded air flow, allowing nitriding of Si and Al, and the formation of the SiAlON phase in ambient air conditions. This study not only presents a strategy to successfully recycle aluminum dross and silicon solid waste but also offers a straightforward approach to preparing SiAlON material in air atmosphere.
A Novel Hybrid Firefly Algorithm with Double-Level Learning Strategy
Authors: Wang Yufeng , Zhao Yubo , Xu Chunyu , Zhan Ying , Chen Ke
Published: August 2023

The firefly algorithm (FA) is a swarm intelligence algorithm capable of solving global optimization problems exactly; it has been used to solve many practical problems. However, traditional firefly algorithms solve complex optimization problems with a simple update method, which leads to premature stagnation due to the limitation of firefly diversity. To overcome these drawbacks, a novel hybrid firefly algorithm (HFA-DLL) with a double-level learning strategy is proposed. In HFA-DLL, a double-level learning strategy is proposed to avoid premature convergence and enhance the algorithm’s global search capability. At the same time, a competitive elimination mechanism is introduced to increase the accuracy of solving complex optimization problems and improve the convergence rate of the algorithm. Moreover, a stochastic disturbance strategy is designed to help the best solution jump out of the local optimum and minimize the time cost in the wrong direction. To understand the advantages and disadvantages of HFA-DLL, experiments were conducted on the CEC 2017 benchmark suite. Experimental results show that HFA-DLL outperforms other state-of-art algorithms in terms of convergence rate and exploration efficiency.
GA-KELM: Genetic-Algorithm-Improved Kernel Extreme Learning Machine for Traffic Flow Forecasting
Authors: Chai Wenguang , Zheng Yuexin , Tian Lin , Qin Jing , Zhou Teng
Published: August 2023

A prompt and precise estimation of traffic conditions on the scale of a few minutes by analyzing past data is crucial for establishing an effective intelligent traffic management system. Nevertheless, because of the irregularity and nonlinear features of traffic flow data, developing a prediction model with excellent robustness poses a significant obstacle. Therefore, we propose genetic-search-algorithm-improved kernel extreme learning machine, termed GA-KELM, to unleash the potential of improved prediction accuracy and generalization performance. By substituting the inner product with a kernel function, the accuracy of short-term traffic flow forecasting using extreme learning machines is enhanced. The genetic algorithm evades manual traversal of all possible parameters in searching for the optimal solution. The prediction performance of GA-KELM is evaluated on eleven benchmark datasets and compared with several state-of-the-art models. There are four benchmark datasets from the A1, A2, A4, and A8 highways near the ring road of Amsterdam, and the others are D1, D2, D3, D4, D5, D6, and P, close to Heathrow airport on the M25 expressway. On A1, A2, A4, and A8, the RMSEs of the GA-KELM model are 284.67 vehs/h, 193.83 vehs/h, 220.89 vehs/h, and 163.02 vehs/h, respectively, while the MAPEs of the GA-KELM model are 11.67%, 9.83%, 11.31%, and 12.59%, respectively. The results illustrate that the GA-KELM model is obviously superior to state-of-the-art models.
Variational Disentangle Zero-Shot Learning
Authors: Su Jie , Wan Jinhao , Li Taotao , Li Xiong , Ye Yuheng
Published: August 2023

Existing zero-shot learning (ZSL) methods typically focus on mapping from the feature space (e.g., visual space) to class-level attributes, often leading to a non-injective projection. Such a mapping may cause a significant loss of instance-level information. While an ideal projection to instance-level attributes would be desirable, it can also be prohibitively expensive and thus impractical in many scenarios. In this work, we propose a variational disentangle zero-shot learning (VDZSL) framework that addresses this problem by constructing variational instance-specific attributes from a class-specific semantic latent distribution. Specifically, our approach disentangles each instance into class-specific attributes and the corresponding variant features. Unlike transductive ZSL, which assumes that unseen classes’ attributions are known beforehand, our VDZSL method does not rely on this strong assumption, making it more applicable in real-world scenarios. Extensive experiments conducted on three popular ZSL benchmark datasets (i.e., AwA2, CUB, and FLO) validate the effectiveness of our approach. In the conventional ZSL setting, our method demonstrates an improvement of 12∼15% relative to the advanced approaches and achieves a classification accuracy of 70% on the AwA2 dataset. Furthermore, under the more challenging generalized ZSL setting, our approach can gain an improvement of 5∼15% compared with the advanced methods.
Some Theoretical and Computational Aspects of the Truncated Multivariate Skew-Normal/Independent Distributions
Authors: Morán-Vásquez Raúl Alejandro , Zarrazola Edwin , Nagar Daya K.
Published: August 2023

In this article, we derive a closed-form expression for computing the probabilities of p-dimensional rectangles by means of a multivariate skew-normal distribution. We use a stochastic representation of the multivariate skew-normal/independent distributions to derive expressions that relate their probability density functions to the expected values of positive random variables. We also obtain an analogous expression for probabilities of p-dimensional rectangles for these distributions. Based on this, we propose a procedure based on Monte Carlo integration to evaluate the probabilities of p-dimensional rectangles through multivariate skew-normal/independent distributions. We use these findings to evaluate the probability density functions of a truncated version of this class of distributions, for which we also suggest a scheme to generate random vectors by using a stochastic representation involving a truncated multivariate skew-normal random vector. Finally, we derive distributional properties involving affine transformations and marginalization. We illustrate graphically several of our methodologies and results derived in this article.
Echinochrome Ameliorates Physiological, Immunological, and Histopathological Alterations Induced by Ovalbumin in Asthmatic Mice by Modulating the Keap1/Nrf2 Signaling Pathway
Authors: Abdelmawgood Islam Ahmed , Mahana Noha Ahmed , Badr Abeer Mahmoud , Mohamed Ayman Saber , Al Shawoush Abdeljalil Mohamed , Atia Tarek , Abdelrazak Amir Elhadi , Sakr Hader I.
Published: August 2023

Asthma is a persistent inflammatory disease of the bronchi characterized by oxidative stress, airway remodeling, and inflammation. Echinochrome (Ech) is a dark-red pigment with antioxidant and anti-inflammatory activities. In this research, we aimed to investigate the effects of Ech against asthma-induced inflammation, oxidative stress, and histopathological alterations in the spleen, liver, and kidney in mice. Mice were divided into four groups (n = 8 for each): control, asthmatic, and asthmatic mice treated intraperitoneally with 0.1 and 1 mg/kg of Ech. In vitro, findings confirmed the antioxidant and anti-inflammatory activities of Ech. Ech showed antiasthmatic effects by lowering the serum levels of immunoglobulin E (IgE), interleukin 4 (IL-4), and interleukin 1β (IL-1β). It attenuated oxidative stress by lowering malondialdehyde (MDA) and nitric oxide (NO) contents and increasing reduced glutathione (GSH), superoxide dismutase (SOD), glutathione-s-transferase (GST), and catalase (CAT) in the liver, spleen, and kidney. Moreover, it protected asthma-induced kidney and liver functions by increasing total protein and albumin and decreasing aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine, urea, and uric acid levels. Additionally, it ameliorated histopathological abnormalities in the lung, liver, spleen, and kidney. Additionally, molecular docking studies were used to examine the interactions between Ech and Kelch-like ECH-associated protein 1 (Keap1). PCR and Western blot analyses confirmed the association of Ech with Keap1 and, consequently, the regulatory role of Ech in the Keap1-(nuclear factor erythroid 2-related factor 2) Nrf2 signaling pathway in the liver, spleen, and kidney. According to our findings, Ech prevented asthma and its complications in the spleen, liver, and kidney. Inhibition of inflammation and oxidative stress are two of echinochrome’s therapeutic actions in managing asthma by modulating the Keap1/Nrf2 signaling pathway.
Are Whiplash-Associated Disorders and Temporomandibular Disorders in a Trauma Related Cause and Effect Relationship? A Review
Authors: Montemurro Nicola , Trilli Irma , Bordea Ioana Roxana , Ferrara Elisabetta , Francesco Maurizio De , Caccamo Francesca , Malcangi Giuseppina , Rapone Biagio
Published: August 2023

Background: Whiplash is associated with a wide variety of clinical manifestations, including headache, neck pain, cervical rigidity, shoulder and back pain, paresthesia, vertigo, and temporomandibular disorders (TMDs). Previous studies reported that TMDs are more common in individuals with chronic whiplash-associated disorders (WAD) than in the general population; however, the pathophysiology and mechanism of this relationship are still not well understood. Methods: A PubMed and Ovid EMBASE review was performed to identify all studies addressing the trauma related cause and effect relationship between WAD and TMDs from January 2003 to March 2023. Results: After screening for eligibility and inclusion criteria, a total of 16 articles met the selection criteria. The various included studies discussed different aspects of the association between WDA and TMDs, including changes in the coordination and amplitude of jaw opening, the severity of the associated symptoms/signs in cases of WAD, the degree of fatigue and psychological stress, difficulty in feeding, cervical and myofascial pain, changes in the MRI signal at various muscle points, muscle tenderness, and quality of life. Conclusions: In this review, we summarized the clinical evidence of any trauma related cause and effect relationship between whiplash and TMDs. An accurate screening of the previous literature showed that, in conclusion, the relationship between whiplash and TMDs is still unclear.
Collagen-Based Ovule Therapy Reduces Inflammation and Improve Cervical Epithelialization in Patients with Fungal, Viral, and Bacterial Cervico-Vaginitis
Authors: De Rosa Nicoletta , Santangelo Fabrizia , Todisco Celestino , Dequerquis Fabiana , Santangelo Claudio
Published: August 2023

Background and Objectives: Vulvovaginal infections pose significant health challenges for women, necessitating effective treatment approaches. This retrospective observational study aimed at investigating the efficacy of collagen-based vaginal ovules therapy, specifically Plurigin Ovules, in restoring cervical epithelialization and reducing inflammation in mycotic, viral, and bacterial cervico-vaginitis. Materials and Methods: A total of 398 women with cervico-vaginitis were included in the study, categorized into three groups: bacterial cervico-vaginitis (Group A), viral cervico-vaginitis (Group B), and fungal cervico-vaginitis (Group C). Participants received vaginal therapy with Plurigin Ovules for three months. Vaginal health parameters were assessed at baseline (T0) and after six months (T1) using various diagnostic tests and analyzed with appropriate statistical tests. Results: Significant improvement in cervico-vaginitis was observed in all three groups. At T1, 87.7% patients of Group A, 66.7% of Group B, and 71.5% of Group C achieved infection resolution (all p < 0.05). Positive colposcopy results decreased across all groups (p < 0.001). Positive vaginal swabs and altered vaginal pH decreased in group A and C (p < 0.001). Positive HPV tests decreased in Group B (p < 0.001). Positive Pap tests and clinical examinations decreased significantly across all groups (p < 0.001). The odds ratios were calculated to reveal the significant associations between these diagnostic outcomes. The therapy was well-tolerated, and no major adverse events were reported. Conclusion: Plurigin Ovules exhibited promising therapeutic outcomes in the three cervico-vaginitis conditions studied. Bacterial cervico-vaginitis showed the most significant improvement, followed by fungal and viral cervico-vaginitis. These findings emphasize the potential of Plurigin Ovules as an effective therapeutic option for cervico-vaginal inflammation and infection, highlighting its role in promoting re-epithelialization and reducing inflammatory processes in the cervix and vagina.
MID-FTIR-PLS Chemometric Analysis of Cr(VI) from Aqueous Solutions Using a Polymer Inclusion Membrane-Based Sensor
Authors: Martínez de la Peña Armando , Rodríguez de San Miguel Eduardo , de Gyves Josefina
Published: August 2023

A partial least squares (PLS) quantitative chemometric method based on the analysis of the mid-Fourier transform infrared spectroscopy (MID-FTIR) spectrum of polymer inclusion membranes (PIMs) used for the extraction of Cr(VI) from aqueous media is developed. The system previously optimized considering the variables membrane composition, extraction time, and pH, is characterized in terms of its adsorption isotherm, distribution coefficient, extraction percent, and enrichment factor. A Langmuir-type adsorption behavior with KL = 2199 cm3/mmol, qmax = 0.188 mmol/g, and 0 < RL < 1 indicates that metal adsorption is favorable. The characterization of the extraction reaction is performed as well, showing a 1:1 Cr(VI):Aliquat 336 ratio, in agreement with solvent extraction data. The principal component analysis (PCA) of the PIMs reveals a complex pattern, which is satisfactorily simplified and related to Cr(VI) concentrations through the use of a variable selection method (iPLS) in which the bands in the ranges 3451–3500 cm−1 and 3751–3800 cm−1 are chosen. The final PLS model, including the 100 wavelengths selected by iPLS and 10 latent variables, shows excellent parameter values with root mean square error of calibration (RMSEC) of 3.73115, root mean square error of cross-validation (RMSECV) of 6.82685, bias of −1.91847 × 10−13, cross-validation (CV) bias of 0.185947, R2 Cal of 0.98145, R2 CV of 0.940902, recovery% of 104.02 ± 4.12 (α = 0.05), sensitivity% of 0.001547 ppb, analytical sensitivity (γ) of 3.8 ppb, γ−1: 0.6 ppb−1, selectivity of 0.0155, linear range of 5.8–100 ppb, limit of detection (LD) of 1.9 ppb, and limit of quantitation (LQ) of 5.8 ppb. The developed PIM sensor is easy to implement as it requires few manipulations and a reduced number of chemical compounds in comparison to other similar reported systems.
Anion-Exchange Membrane “Polikon A” Based on Polyester Fiber Fabric (Functionalized by Low-Temperature High-Frequency Plasma) with Oxidized Metal Nanoparticles
Authors: Terin Denis , Kardash Marina , Ainetdinov Denis , Turaev Timur , Sinev Ilya
Published: August 2023

An experimental laboratory set of samples of composite heterogeneous anion-exchange membranes was obtained by us for the development of our original method of polycondensation filling. Anion-exchange membranes were prepared on plasma-treated and non-plasma-treated polyester fiber fabrics. The fabric was treated with low-temperature argon plasma at a power of 400 W for 10 min at a pressure of 5 × 10−5 mbar. On the surface and bulk of the polyester fiber, a polyfunctional anionite of mixed basicity was synthesized and formed. The anion-exchange membrane contained secondary and tertiary amino groups and quaternary ammonium groups, which were obtained from polyethylene polyamines and epichlorohydrins. At the stage of the chemical synthesis of the anion matrix, oxidized nanoparticles (~1.5 wt.%) of silicon, nickel, and iron were added to the monomerization composition. The use of ion-plasma processing of fibers in combination with the introduction of oxidized nanoparticles at the synthesis stage makes it possible to influence the speed and depth of the synthesis and curing processes; this changes the formation of the surface morphology and the internal structure of the ion-exchange polymer matrix, as well as the hydrophobic/hydrophilic balance and—as a result—the different operational characteristics of anion-exchange membranes.
Effect of the Reinforcing Particle Introduction Method on the Tribomechanical Properties of Sintered Al-Sn-Fe Alloys
Authors: Rusin Nikolay M. , Skorentsev Alexander L. , Dmitriev Andrey I.
Published: August 2023

The present paper reports the results of the comparative study of mechanical properties of sintered disperse-strengthened Al–40Sn alloy depending on the method of reinforcing particle introduction. The study is performed on two mixtures of aluminum and tin powders: one is admixed with 5.5–14.6 wt% of pure iron powder and the other contains the same amount of iron, but as a component of aluminide Al3Fe powders. The volume fraction of tin remains unchanged in all mixtures, being equal to 20%, and the concentration of hard particles increases due to a decrease in the volume fraction of the aluminum phase. Green compacts are sintered in the vacuum furnace at a temperature above the melting point of aluminum. The sintered material is a composite containing three phases: α-Al, β-Sn, and Al3Fe, in which the tin volume fraction is constant. Testing of the sintered composites for compression shows that the addition of finished Al3Fe particles has a more beneficial effect on their mechanical properties as compared to the addition of pure iron powders. In the latter case, aluminides are formed during sintering. The ultimate strength of composites reaches 180 MPa. Mechanisms of sintering of composites and the related structure and mechanical properties are discussed.
High-Performance Applications of Metals and Alloys: Material Properties, Behaviour Modeling, Optimal Design and Advanced Processes
Authors: Fragassa Cristiano , Lesiuk Grzegorz , Epp Jeremy
Published: August 2023

Metals have played an immensely significant role throughout the history of humanity, to the extent that different periods of human development have been marked by the dominance of specific materials, such as the Bronze Age and the Iron Age [...]
The Native Microbiome Member Chryseobacterium sp. CHNTR56 MYb120 Induces Trehalose Production via a Shift in Central Carbon Metabolism during Early Life in C. elegans
Authors: Shiri Tanisha Jean , Viau Charles , Gu Xue , Xu Lei , Lu Yao , Xia Jianguo
Published: August 2023

Aging is the system-wide loss of homeostasis, eventually leading to death. There is growing evidence that the microbiome not only evolves with its aging host, but also directly affects aging via the modulation of metabolites involved in important cellular functions. The widely used model organism C. elegans exhibits high selectivity towards its native microbiome members which confer a range of differential phenotypes and possess varying functional capacities. The ability of one such native microbiome species, Chryseobacterium sp. CHNTR56 MYb120, to improve the lifespan of C. elegans and to promote the production of Vitamin B6 in the co-colonizing member Comamonas sp. 12022 MYb131 are some of its beneficial effects on the worm host. We hypothesize that studying its metabolic influence on the different life stages of the worm could provide further insights into mutualistic interactions. The present work applied LC-MS untargeted metabolomics and isotope labeling to study the impact of the native microbiome member Chryseobacterium sp. CHNTR56 MYb120 on the metabolism of C. elegans. In addition to the upregulation of biosynthesis and detoxification pathway intermediates, we found that Chryseobacterium sp. CHNTR56 MYb120 upregulates the glyoxylate shunt in mid-adult worms which is linked to the upregulation of trehalose, an important metabolite for desiccation tolerance in older worms.
Microcystin Concentrations and Detection of the mcyA Gene in Water Collected from Agricultural, Urban, and Recreational Areas in a Karst Aquifer in the Yucatan Peninsula of Mexico
Authors: Ávila-Torres Gerardo , Rosiles-González Gabriela , Carrillo-Jovel Victor Hugo , Acosta-González Gilberto , Cejudo-Espinosa Eduardo , Ortega-Camacho Daniela , Hernández-Zepeda Cecilia , Valenzuela Oscar Alberto Moreno
Published: August 2023

The eutrophication of freshwater ecosystems allows the proliferation of cyanobacteria that can produce secondary metabolites such as microcystins. The main aim of this study was to explore the occurrence and concentration of microcystin and the mcyA gene in water bodies located in agricultural, urban, and recreational areas in the karst aquifer of the Yucatan peninsula of Mexico (YPM) and to analyze the water quality variables and chlorophyll-a (Chl-a) associated with their presence. Water samples were collected from 14 sites, and microcystin concentrations were quantified using antibody-based ELISA test. Total DNA was isolated from filters and used for PCR amplification of a fragment of the mcyA gene. Amplicons were cloned and sequenced to identify toxin-producing cyanobacteria present in water. Results showed that water bodies had different trophic status based on Carlson’s trophic state index. Dissolved inorganic nitrogen (DIN: NH4+ + NO3− + NO2−) and P-PO43− concentrations were within a range of 0.077–18.305 mg DIN/L and 0.025–2.5 mg P-PO43−/L, respectively, per sampled site. All sampled sites presented microcystin concentrations within a range of ≥0.14 µg/L to ≥5.0 µg/L, from which 21.4% (3/14) exceeded the limit established in water quality standards for water consumption (1 µg/L). The mcyA gene fragment was detected in 28.5% (4/14) of the sites. A total of 23 sequences were obtained from which 87% (20/23) shared >95% nucleotide identity (nt) with the genus Microcystis and 13% (3/23) shared >87% nt identity with uncultured cyanobacteria. No correlation with the presence of the mcyA gene and microcystins was found; however, a positive correlation was detected between microcystin concentrations with pH and Chl-a.