bluuebunny/crossref_metadata_2025 huggingface dataset:
Revealing the Role of Spacer Layer in Domain Dynamics of Hf0.5Zr0.5O2 Thin Films for Ferroelectrics
Authors: Peng Ren‐Ci , Wen Shubin , Cheng Xiaoxing , Chen Long‐Qing , Liao Min , Zhou Yichun
Published: May 2024

HfO2‐based ferroelectrics offer promises for next‐generation nonvolatile nanoscale devices owing to excellent CMOS compatibility and robust ferroelectricity at the nanoscale. However, fundamentally understanding the mechanism of polarization reversal and domain dynamics is challenging because the role of the spacer layer at the domain level in HfO2‐based ferroelectrics remains elusive. Here, it is realized that visualization of time‐resolved dynamics of nanoscale domain configurations in the epitaxial Hf0.5Zr0.5O2 thin films using phase‐field simulations. Scale‐free domain independent switchability (namely, irreducible stable polar domain down to 1 nm lateral size) and sharp domain walls that originate from weak interactions between adjacent domains characterized by the reduced gradient energy coefficient, which unravels the mesoscale mechanism of spacer layer in domain dynamics are demonstrated. Meanwhile, it is revealed that 180° polarization switching is dominated by the nucleation of a new domain with a high nucleation density, well described by the nucleation‐limited switching model. This study not only provides a fundamental mesoscale mechanism of the spacer layer, but also stimulates further studies on the manipulation of ultra‐scaled single domain state for designing high‐density and fast‐speed HfO2‐based ferroelectric memory.
Superior Self‐Lubricating Coatings with Heterogeneous Nanocomposite Structures on Ti–Nb–Zr–Ta–Hf Refractory Multi‐Principal Element Alloy
Authors: Zhang Ge , Chen Yisong , Cao Yuankui , Liu Bin , Huang Qianli , Liu Yong
Published: May 2024

There is tremendous interest in the development of highly wear‐resistant coatings for metallic materials to reduce energy loss and prolong service life. In this study, the authors propose an approach to develop nanocomposite coatings featuring deformable nanocrystals embedded in amorphous matrix for self‐lubrication and superior wear resistance. The dual‐layered nanocomposite coatings are prepared by plasma electrolytic oxidation (PEO) on a Ti‐Nb‐Ta‐Zr‐Hf (TNZTH) refractory multi‐principal element alloy (RMPEA) and commercially pure Ti (cpTi). The inner layers of PEO coatings are composed of substrate element oxides (amorphous TNZTH─O oxide or anatase TiO2), while their outer layers exhibit typical nanocomposite structures. Different from the cpTi‐based PEO coating outer layers composed of brittle rutile TiO2 nanoparticles dispersed in an amorphous matrix of SiO2 and Na2O·nSiO2, the outer layers of TNZTH‐based PEO coatings are featured by deformable Na2Zr(Hf)O3 nanocrystals heterogeneously embedded in an inhomogeneous amorphous matrix composed of TNZTH─O oxide, SiO2, and Na2O·nSiO2. As a result, the TNZTH‐based PEO coatings exhibit favorable self‐lubricating performance and superior wear resistance, while the cpTi‐based PEO coatings are completely destroyed after sliding wear. Thus, this study offers valuable insights into the design and development of self‐lubricating coatings with superior wear resistance for metallic materials.
Multiscale Heterogeneous Polymer Composites for High Stiffness 4D Printed Electrically Controllable Multifunctional Structures
Authors: Ferrer Javier M. Morales , Cruz Ramón E. Sánchez , Caplan Sophie , Van Rees Wim M. , Boley J. William
Published: May 2024

4D printing is an emerging field where 3D printing techniques are used to pattern stimuli‐responsive materials to create morphing structures, with time serving as the fourth dimension. However, current materials utilized for 4D printing are typically soft, exhibiting an elastic modulus (E) range of 10−4to 10 MPa during shape change. This restricts the scalability, actuation stress, and load‐bearing capabilities of the resulting structures. To overcome these limitations, multiscale heterogeneous polymer composites are introduced as a novel category of stiff, thermally responsive 4D printed materials. These inks exhibit anEthat is four orders of magnitude greater than that of existing 4D printed materials and offer tunable electrical conductivities for simultaneous Joule heating actuation and self‐sensing capabilities. Utilizing electrically controllable bilayers as building blocks, a flat geometry is designed and printed that morphs into a 3D self‐standing lifting robot, setting new records for weight‐normalized load lifted and actuation stress when compared to other 3D printed actuators. Furthermore, the ink palette is employed to create and print planar lattice structures that transform into various self‐supporting complex 3D shapes. These contributions are integrated into a 4D printed electrically controlled multigait crawling robotic lattice structure that can carry 144 times its own weight.
Exploring Metal Electroplating for Energy Storage by Quartz Crystal Microbalance: A Review
Authors: Vanoppen Viktor , Johannsmann Diethelm , Hou Xu , Sjölund Jens , Broqvist Peter , Berg Erik J.
Published: May 2024

The development and application of Electrochemical Quartz Crystal Microbalance (EQCM) sensing to study metal electroplating, especially for energy storage purposes, are reviewed. The roles of EQCM in describing electrode/electrolyte interface dynamics, such as the electric double‐layer build‐up, ionic/molecular adsorption, metal nucleation, and growth, are addressed. Modeling of the QCM sensor is introduced and its importance is emphasized. Challenges of metal electrode use, including side reactions and dendrite formation, along with their mitigation strategies are reviewed. Numerous factors affecting the electroplating processes, such as electrolyte composition, additives, temperature, and current density, and their influence on the electroplated metals’ mass, structural, and mechanical characteristics are discussed. Looking forward, the need for deeper fundamental understanding and advancing simulations of the QCM signal response as a result of electroplating metal nanostructures is stressed. Further development and integration of innovative EQCM‐strategies will provide unique future means to fundamentally understand and optimize metal electroplating for energy storage and application alike.
Twin Irida Graphene: A Carbon Material with Optoelectronic Features
Authors: Majidi Roya , Ayesh Ahmad I.
Published: May 2024

A novel allotrope structure of carbon named twin irida graphene composed of 3‐16‐8 carbon rings is proposed. Its structural, mechanical, electronic, and optical characteristics are explored by density functional theory. It is shown that twin irida graphene has an energetically favorable structure. Its dynamical and thermal stabilities at room temperature are also examined and confirmed. The in‐plane stiffness of twin irida graphene is less than graphene. It is a metal and maintains this property even against the external strain and applied electric field. This sheet exhibits an anisotropy response to the incident photon with different polarizations. The potential of sheet for use in energy storage and absorption systems is indicated by its high dielectric constant and optical absorption. The reflection constants as well as the transmission constants of twin irida graphene indicate its transparency, mostly in the high‐energy region. Thus, twin irida graphene is a suitable material for use in optoelectronic applications due to its structural and physical characteristics.
Additive Manufacturing Provides Infinite Possibilities for Self‐Sensing Technology
Authors: Chen Daobing , Han Zhiwu , Zhang Junqiu , Xue Longjian , Liu Sheng
Published: May 2024

Integrating sensors and other functional parts in one device can enable a new generation of integrated intelligent devices that can perform self‐sensing and monitoring autonomously. Applications include buildings that detect and repair damage, robots that monitor conditions and perform real‐time correction and reconstruction, aircraft capable of real‐time perception of the internal and external environment, and medical devices and prosthetics with a realistic sense of touch. Although integrating sensors and other functional parts into self‐sensing intelligent devices has become increasingly common, additive manufacturing has only been marginally explored. This review focuses on additive manufacturing integrated design, printing equipment, and printable materials and stuctures. The importance of the material, structure, and function of integrated manufacturing are highlighted. The study summarizes current challenges to be addressed and provides suggestions for future development directions.
Applying the master adaptive learner framework to just‐in‐time training of procedures
Authors: Alvarez Al'ai , Manthey David , Promes Susan B. , Haas Mary , Santen Sally A. , Wagner Jason , Schnapp Benjamin
Published: May 2024

Background

Just‐in‐time training (JITT) occurs in the clinical context when learners need immediate guidance for procedures due to a lack of proficiency or the need for knowledge refreshment. The master adaptive learner (MAL) framework presents a comprehensive model of transforming learners into adaptive experts, proficient not only in their current tasks but also in the ongoing development of lifelong skills. With the evolving landscape of procedural competence in emergency medicine (EM), trainees must develop the capacity to acquire and master new techniques consistently. This concept paper will discuss using JITT to support the development of MALs in the emergency department.

Methods

In May 2023, an expert panel from the Society for Academic Emergency Medicine (SAEM) Medical Educator's Boot Camp delivered a comprehensive half‐day preconference session entitled “Be the Best Teacher” at the society's annual meeting. A subgroup within this panel focused on applying the MAL framework to JITT. This subgroup collaboratively developed a practical guide that underwent iterative review and refinement.

Results

The MAL‐JITT framework integrates the learner's past experiences with the educator's proficiency, allowing the educational experience to address the unique requirements of each case. We outline a structured five‐step process for applying JITT, utilizing the lumbar puncture procedure as an example of integrating the MAL stages of planning, learning, assessing, and adjusting. This innovative approach facilitates prompt procedural competence and cultivates a positive learning environment that fosters acquiring adaptable learning skills with enduring benefits throughout the learner's career trajectory.

Conclusions

JITT for procedures holds the potential to cultivate a dynamic learning environment conducive to nurturing the development of MALs in EM.
Local sorghum (Sorghum bicolor (L.) Moench) on‐farm genetic diversity status and possible determinants from Wollo lowland areas, northeastern Ethiopia
Authors: Abegaz Silamlak Birhanu
Published: May 2024

Various agricultural crops are the world's sources of food, fodder, and energy. However, conservation management and diversification constraints remain a challenge. Therefore, the present study aimed to assess the status of local agricultural sorghum genetic diversity and potential determinants of the Wollo lowlands in northeastern Ethiopia. The greatest extent of local sorghum abundance was demonstrated in the study areas with the highest value being 4.25 DMg and 2.89 DMn in Werebabo district. However, 2.97 DMg and 2.04 DMn were recorded as the relatively lowest indices in Tehuledere province. In fact, the extent and type of diversity, measured by the number of varieties per farm, varied from region to region. Farmer perceived constraints such as late maturity, blending fluency, distance to nearest market (km), small land ownership, end‐use quality, and plume size attributed to these deviations. The priority of the constraints was first determined by ranking the constraints based on the answers received from the respondents and then calculating the rank‐based quotient. Several categorical variables of these constraints also showed a significant association with the status of local farm sorghum genetic diversity at p < 0.05 and p < 0.001. In general, the status of genetic diversity of local sorghum farms was low in all the provinces studied. Therefore, the seed exchange network between local farmers should be encouraged to use and conserve diversity on a daily basis. Community seed banks should also be established to enhance the conservation of beneficial local sorghum germplasm and maximize locally adapted sorghum landrace profiles.
Multiple instance learning for eosinophil quantification of sinonasal histopathology images: A hierarchical determination on whole slide images
Authors: Hsu Yen‐Chi , Lin Kao‐Tsung , Lee Ming‐Sui , Shen Li‐Sung , Yeh Te‐Huei , Lin Yi‐Tsen
Published: May 2024

Key points

We proposed a hierarchical framework including an unsupervised candidate image selection and a weakly supervised patch image detection based on multiple instance learning (MIL) to effectively estimate eosinophil quantities in tissue samples from whole slide images.

MIL is an innovative approach that can help deal with the variability in cell distribution detection and enable automated eosinophil quantification from sinonasal histopathological images with a high degree of accuracy.

The study lays the foundation for further research and development in the field of automated histopathological image analysis, and validation on more extensive and diverse datasets will contribute to real‐world application.
Antibodies to Malondialdehyde‐Acetaldehyde Adduct Are Associated With Prevalent and Incident Rheumatoid Arthritis–Associated Interstitial Lung Disease in US Veterans
Authors: Aripova Nozima , Thiele Geoffrey M. , Duryee Michael J. , Hunter Carlos D. , Yang Yangyuna , Roul Punyasha , Ascherman Dana P. , Matson Scott M. , Kunkel Gary , Cannon Grant W. , Wysham Katherine D. , Kerr Gail S. , Monach Paul A. , Baker Joshua F. , Poole Jill A. , Mikuls Ted R. , England Bryant R.
Published: May 2024

Objective

The objective of this study is to determine the associations of protein‐specific anti–malondialdehyde‐acetaldehyde (MAA) antibodies with prevalent and incident rheumatoid arthritis–interstitial lung disease (RA‐ILD).

Methods

Within a multicenter, prospective cohort of US veterans with RA, RA‐ILD was validated by medical record review of clinical diagnoses, chest imaging, and pathology. Serum antibodies to MAA‐albumin, MAA‐collagen, MAA‐fibrinogen, and MAA‐vimentin (IgA, IgM, and IgG) were measured by a standardized enzyme‐linked immunosorbent assay. Associations of anti‐MAA antibodies with prevalent and incident RA‐ILD were assessed using multivariable regression models adjusting for established RA‐ILD risk factors.

Results

Among 2,739 participants with RA (88% male, mean age of 64 years), there were 114 with prevalent and 136 with incident RA‐ILD (average time to diagnosis: 6.6 years). Higher IgM anti–MAA‐collagen (per 1 SD: adjusted odds ratio [aOR] 1.28, 95% confidence interval [CI] 1.02–1.61), IgA anti–MAA‐fibrinogen (aOR 1.48, 95% CI 1.14–1.92), and IgA (aOR 1.78, 95% CI 1.34–2.37) and IgG (aOR 1.48, 95% CI 1.14–1.92) anti–MAA‐vimentin antibodies were associated with prevalent RA‐ILD. In incident analyses, higher IgA (per one SD: adjusted hazards ratio [aHR] 1.40, 95% CI 1.11–1.76) and IgM (aHR 1.29, 95% CI 1.04–1.60) anti–MAA‐albumin antibody concentrations were associated with increased ILD risk. Participants with IgA (aHR 2.13, 95% CI 1.16–3.90) or IgM (aHR 1.98, 95% CI 1.08–3.64) anti–MAA‐albumin antibody concentrations in the highest quartile had an approximately two‐fold increased risk of incident RA‐ILD. Across all isotypes, anti–MAA‐fibrinogen, anti–MAA‐collagen, and anti–MAA‐vimentin antibodies were not significantly associated with incident RA‐ILD.

Conclusion

Protein‐specific anti‐MAA antibodies to collagen, fibrinogen, and vimentin were associated with prevalent RA‐ILD. IgA and IgM anti–MAA‐albumin antibodies were associated with a higher risk of incident RA‐ILD. These findings suggest that MAA modifications and resultant immune responses may contribute to RA‐ILD pathogenesis.
Antioxidant activity and cytotoxicity of greigite nanoparticles synthesized by hydrothermal technique
Authors: Naser Dalal Maseer , Lafta Sadeq H. , Hashim Mustafa Shakir
Published: May 2024

The effects of 180, 210, and 230°C reaction temperatures on the structural and magnetic properties of synthesized iron sulfide nanoparticles were studied. The Rietveld refinement analysis result of the X‐ray diffraction data indicated that greigite was the dominant phase in all samples. The sample was prepared at 210°C for 18 h and had a greater wt% ratio of the greigite phase. The crystallite and particle sizes increased with increasing reaction temperatures. Scanning electron microscope images confirmed the presence of aggregation of synthesized rod‐shaped nanoparticles. The magnetic hysteresis curves of all samples showed ferromagnetic behavior at room temperature. The magnetic saturation of three samples increases with increased reaction temperature, but the coercive force has the opposite behavior. Antioxidant activity and cytotoxicity of the sample synthesized at 210°C were investigated. This sample killed cancer cells at relatively moderate and high concentrations with high viability of normal cells, demonstrating the sample's suitability for use in killing cancer cells while avoiding normal cells.
Optimizing recombinant antibody fragment production: A comparison of artificial intelligence and statistical modeling
Authors: Basafa Majid , Hashemi Atieh , Behravan Aidin
Published: May 2024

Maximizing the recombinant protein yield necessitates optimizing the production medium. This can be done using a variety of methods, including the conventional “one‐factor‐at‐a‐time” approach and more recent statistical and mathematical methods such as artificial neural network (ANN), genetic algorithm, etc. Every approach has advantages and disadvantages of its own, yet even when a technique has flaws, it is nevertheless used to get the best results. Here, one categorical variable and four numerical parameters, including post‐induction time, inducer concentration, post‐induction temperature, and pre‐induction cell density, were optimized using the 232 experimental assays of the central composite design. The direct and indirect effects of factors on the yield of anti‐epithelial cell adhesion molecule extracellular domain fragment antibody were examined using statistical methods. The analysis of variance results indicate that the response surface methodology (RSM) model is effective in predicting the amount of produced single‐chain fragment variable (p‐value = 0.0001 and R2 = 0.905). For ANN modeling, the evaluation using normalized root mean square error (NRMSE) and R2 values shows a good fit (R2 = 0.942) and accurate predictions (NRMSE = 0.145). The analysis of error parameters and R2 of a dataset, which contained 30 data points randomly selected from the complete dataset, showed that the ANN model had a higher R2 value (0.968) compared to the RSM model (0.932). Furthermore, the ANN model demonstrated stronger predictive ability with a lower NRMSE (0.048 vs. 0.064). Induction at the cell density of 0.7 and an isopropyl β‐D‐1‐thiogalactopyranoside concentration of 0.6 mM for 32 h at 30°C in BW25113 was the ideal culture condition leading to the protein yield of 259.51 mg/L. Under the optimum conditions, the output values predicted by the ANN model (259.83 mg/L) were more in line with the experimental data (259.51 mg/L) than the RSM (276.13 mg/L) expected value. This outcome demonstrated that the ANN model outperforms the RSM in terms of prediction accuracy.
Amorphous MoS2/MoO3 Nanosheets as High‐Efficient Polysulfide Barrier in Li−S Batteries
Authors: Qing Min , Hao Zhi Hui , Zhao Xiangwei , Dong Qin , He Zhimin , Hong Wei , Li Rong
Published: May 2024

Lithium‐sulfur batteries (LSBs) are seriously impeded by poor reaction kinetics and the polysulfides shuttling, leading to low utilization of sulfur and poor cycling performance. Herein, amorphous MoS2/MoO3 nanosheets are prepared by a one‐step formamide (FA)‐assisted strategy. Due to the merits of high adsorption capability and good catalytic activity of MoS2, relatively high electronic conductivity and strong polarity of MoO3, and abundant active sites of amorphous nanosheet structure, the LSBs based on amorphous MoS2/MoO3‐2 nanosheets coated separator exhibit an outstanding specific capacity (1420.2 mA h g−1 at 0.1 C), excellent rate capacity (505.4 mA h g−1 at 5 C), and long cycle life (a negligible decay rate of 0.063 % per cycle at 0.5 C). This work provides an idea for designing efficient amorphous catalytic materials in LSBs.
Olanzapine‐induced cardiomyopathy: A mimicker of obesity cardiomyopathy?
Authors: Tolu‐Akinnawo Oluwaremilekun Zeth , Awoyemi Toluwalase , Guzman Rocio Barriga , Naveed Akhtar
Published: May 2024

Olanzapine, an atypical antipsychotic medication, has gained prominence in the treatment of schizophrenia and related psychotic disorders due to its effectiveness and perceived safety profile. However, emerging evidence suggests a potential link between olanzapine use and adverse cardiovascular effects, including cardiomyopathy. This narrative review explores the mechanisms, clinical implications, and management strategies associated with olanzapine‐induced cardiomyopathy. A comprehensive review of the literature was conducted to investigate the relationship between olanzapine and cardiomyopathy. The search included epidemiological studies, clinical case reports, and mechanistic research focusing on the pathophysiology of olanzapine‐induced cardiomyopathy. The review also examined treatment strategies for managing this potential complication. Olanzapine‐induced cardiomyopathy is hypothesized to be associated with metabolic disturbances and receptor antagonism. The metabolic effects of olanzapine, such as weight gain, insulin resistance, and dyslipidemia, share similarities with obesity‐related cardiomyopathy. Additionally, olanzapine's antagonism of certain receptors may contribute to cardiovascular stress. The review highlighted that patients with new‐onset heart failure and significant weight gain while on olanzapine should be closely monitored for signs of cardiomyopathy. Early detection and prompt withdrawal of olanzapine, along with initiation of goal‐directed medical therapy, are crucial for mitigating this potentially life‐threatening condition. The relationship between olanzapine and cardiomyopathy is complex and not yet fully understood. However, the potential for significant cardiovascular risk necessitates vigilance among healthcare providers. Early identification and management of olanzapine‐induced cardiomyopathy can improve patient outcomes. Further research is needed to elucidate the precise mechanisms behind this adverse effect and to develop optimized treatment strategies for patients requiring antipsychotic therapy.
Anthracnose and bean common mosaic necrosis virus resistance in wild and landrace Phaseolus vulgaris (L.) genetic stocks
Authors: Awale Halima E. , Wiersma Andrew T. , Wright Evan M. , Buell C. Robin , Kelly James D. , Cichy Karen A. , Haus Miranda J.
Published: May 2024

Wild crop germplasm and landrace varieties have long been considered as a source of novel genetic variation for improving domesticated crops. Due to genetic bottlenecks that occurred during domestication, dissemination, and subsequent crop improvement, many beneficial genes are absent from commercial varieties and elite breeding germplasm, yet are still present in wild populations. To catalog potential novel disease resistance genes useful for breeding more resilient dry beans, we screened wild and landrace Phaseolus vulgaris L. accessions archived in the USDA GRIN seed bank for untapped resistance to anthracnose (Colletotrichum lindemuthianum) and bean common mosaic necrosis virus (BCMNV). A population of 194 wild and 55 landrace accessions were screened for resistance to two highly virulent races of anthracnose (race 2047 and race 3481) and for resistance to the BCMNV strain NL‐3. Thirteen accessions, all wild, were resistant to both anthracnose races, with MX‐QT‐3 and PI 661812 displaying complete resistance with no disease symptoms across all replications. Surprisingly, no natural resistance to BCMNV strain NL‐3 was detected in the wild germplasm. PI 442541, PI 661891, and W6 10164 were the only three accessions that expressed the I‐gene phenotype and all three have some history of cultivation. This study provides a resource for introgression of genetic diversity for anthracnose resistance into cultivated beans and reveals that innate resistance to BCMNV may not exist in wild populations of P. vulgaris.
Reaction Center Shifting in Partially Fluorinated Electrolytes for Robust Lithium Metal Battery
Authors: Yang Tong , Zhang Wenna , Shen Chunli , Ren Long , Liao Xiaobin , Guo Yaqing , Zhao Yan
Published: May 2024

The strategic formulation of a compatible electrolyte plays a pivotal role in extending the longevity of lithium‐metal batteries (LMBs). Here, we present findings on a partially fluorinated electrolyte distinguished by a subdued solvation affinity towards Li+ ions and a concentrated anion presence within the primary solvation layer. This distinctive solvation arrangement redirects the focal points of reactions from solvent molecules to anions, facilitating the predominant involvement of anions in the creation of a LiF‐enriched solid‐electrolyte interphase (SEI). Electrochemical assessments showcase effective Li+ transport kinetics, diminished overpotential polarization for Li nucleation (28 mV), and prolonged cycling durability in Li||Li cells employing the partially fluorinated electrolyte. When tested in Li||NCM811 cells, the designed electrolyte delivers a capacity retention of 89.30 % and exhibits a high average Coulombic efficiency of 99.80 % over 100 cycles with a charge‐potential cut‐off of 4.6 V vs. Li/Li+ under the current density of 0.4C. Furthermore, even at a current density of 1C, the cells maintain 81.90 % capacity retention and a high average Coulombic efficiency of 99.40 % after 180 cycles. This work underscores the significance of weak‐solvation interaction in partially fluorinated electrolytes and highlights the crucial role of solvent structure in enabling the long‐term stability and high‐energy density of LMBs.
Campylotropis xinfeniae (Fabaceae, Papilionoideae), a new species from Yunnan, China, based on morphological and molecular evidence
Authors: Jiang Li‐Sha , Li Xin‐Hui , Li Xiong , Xu Bo
Published: May 2024

Campylotropis xinfeniae, a new species from the dry‐hot valley of the Jinsha River in the Yunnan province, China, is described and illustrated. It is morphologically similar to C. wilsonii and C. brevifolia in having glabrescent old branches, absent stipels, 3‐foliolate leaves, and adaxially puberulent leaflets, while it differs from the latter two in having often paniculate inflorescences, obviously white standard, not incurved sickle keel, larger narrowly oblique legumes, and longer legume beak. The complete chloroplast genome of this new species is 149,073 bp in length and exhibits a typical quadripartite structure. Phylogenetic analyses based on the complete chloroplast genome also supported C. xinfeniae as a new species located at the basal distinct clade of the genus Campylotropis, clearly separated from the remaining members of the genus and its allied genera. A conservation assessment of data deficient (DD) is recommended for the new species without extensive exploring of similar habitats according to the IUCN Categories and Criteria.
Cu‐Catalyzed Synthesis of [1,2,3]triazolo[1,5‐c]quinazolin‐5(6H)‐one Derivatives via Sequential Reaction of Ethyl‐2‐(2‐oxoindolin‐3‐ylidene)acetate with Sodium Azide
Authors: Ghosh Somnath , Mohanta Nirmala , Gnanaprakasam Boopathy
Published: May 2024

Herein, we report a novel and efficient method for the synthesis of new class of 5‐oxo‐5,6‐dihydro‐[1,2,3]triazolo[1,5‐c]quinazoline derivatives by copper‐catalyzed reaction of α, β‐unsaturated keto/ester methyleneindolinone with sodium azide at room temperature via an azide‐alkene cyclization and ring expansion rearrangement. This method is applicable to a variety of α, β‐unsaturated keto/ester methyleneindolinone and displayed wide functional group tolerance.
Hampton University launches School of Religion
Authors: Elfman Lois
Published: May 2024

Hampton University, a renowned historically Black university in Virginia, recently announced the establishment of a School of Religion. The university has hosted the Hampton University Ministers’ Conference (HUMC, a professional development conference) for more than a century and took this year's conference as the time to announce the new school.
Disclosures 12: Request for mailing labels and legitimate educational interest
Authors: Rainsberger Richard
Published: May 2024

The most frequent FERPA issue that occurs when disclosing education records internally to school officials is assuring that a legitimate educational interest exists before disclosing those education records. And it is important that, in making a disclosure to a school official, we are FERPA‐compliant.
Deep learning‐based seizure prediction using EEG signals: A comparative analysis of classification methods on the CHB‐MIT dataset
Authors: Esmaeilpour Ali , Tabarestani Shaghayegh Shahiri , Niazi Alireza
Published: May 2024

Epilepsy is a brain disorder that causes patients to have multiple seizures. About 30% of patients with epilepsy are not treated with medication or surgery. The abnormal activity of brain before occurring of a seizure (about a few minutes before a seizure occurs) are known as the preictal area. Therefore, if we can predict this state, we can control possible seizures by using appropriate medications. In this study, we present a method for predicting epileptic seizures using electroencephalogram (EEG) signals. The method can identify the preictal region that occurs before the onset of seizures. In our proposed method, first the noise removal of EEG signals is performed, and then the necessary features are extracted using a convolution neural network. Finally, we use the feature vectors in order to train multiple classifiers, fully connected layer, random forest, and support vector machines with linear kernel. Additionally, we apply maximum voting, which is an ensemble method, to classify preictal segments from interictal ones. In this study, using EEG signals of patients from CHB‐MIT dataset, we were able to achieve sensitivity of 90.76%.
Enhanced removing of cyanobacterium by NZVI coupled with H2O2: Influencing factors and removal mechanisms
Authors: Ji Lipeng , Lu Hao , Wang Yue , Chu Fuhao , Wang Danni , Li Jiake , Mo Shuhong , Kong Yun
Published: May 2024

As advanced oxidation processes (AOPs) is considered to be a highly effective approach for degrading organic pollutants, the simultaneous coagulation and oxidation process by the Fenton‐like reaction of nanoscale zero‐valent iron (NZVI) and hydrogen peroxide (H2O2) is investigated to eliminate the harmful cyanobacterium Microcystis aeruginosa in this study, and the process conditions are optimized using the central composite design of response surface methodology (RSM); in addition, the removal efficiency of M. aeruginosa (in terms of chlorophyll a, Chl a) and the verifications of the antioxidant abilities, as well as extracellular organic matters (EOM) and intracellular organic matters (IOM) are investigated under the optimized conditions. Results indicate that H2O2 concentration is the key factor affecting the Chl a removal efficiency, and the maximum Chl a removal reaches 98.10% under the optimized conditions: NZVI concentration 62.82 mg L−1, H2O2 concentration 54.2 mmol L−1, pH 4.38 and rotating speed 67 rpm. The high correlation coefficient (R2 > 0.80) of analysis of variance (ANOVA) demonstrates the RSM model is extremely significant and suitable for experimental results. Moreover, the total organic carbon (TOC) and fluorescent substances (soluble cyanobacteria metabolic byproducts, aromatic proteins II, humic and fulvic acid‐like compounds) for both EOM and IOM are enhanced removal. It is speculated the removal mechanisms of the Fenton‐like process of NZVI/H2O2 for cyanobacterium belongs to the combined actions of the oxidation of Fe(II)/H2O2 and the coagulation of Fe(III), which destroy the defense system and result in the removal of M. aeruginosa.
Drosophila models of the anti‐inflammatory and anti‐obesity mechanisms of kombucha tea produced by Camellia sinensis leaf fermentation
Authors: Tran Duy Binh , Le Nguyen Khoi Nguyen , Duong Minh Tue , Yuna Kamo , Pham L. A. Tuan , Nguyen Q. C. Thanh , Tragoolpua Yingmanee , Kaewkod Thida , Kamei Kaeko
Published: May 2024

Kombucha tea is a traditional beverage originating from China and has recently gained popularity worldwide. Kombucha tea is produced by the fermentation of tea leaves and is characterized by its beneficial properties and varied chemical content produced during the fermentation process, which includes organic acids, amino acids, vitamins, minerals, and other biologically active compounds. Kombucha tea is often consumed as a health drink to combat obesity and inflammation; however, the bioactive effects of kombucha tea have not been thoroughly researched. In this study, we reveal the underlying mechanisms of the beneficial properties of kombucha tea and how they protect against obesity and inflammation by studying Drosophila models. We established an inflammatory Drosophila model by knocking down the lipid storage droplet‐1 gene, a human perilipin‐1 ortholog. In this model, dysfunction of lipid storage droplet‐1 induces inflammation by enhancing the infiltration of hemocytes into adipose tissues, increasing reactive oxygen species production, elevating levels of proinflammatory cytokines, and promoting the differentiation of hemocytes into macrophages. These processes are regulated by the c‐Jun N‐terminal Kinase (JNK) pathway. Using this unique Drosophila model that mimics mammalian inflammation, we verified the beneficial effects of kombucha tea on reducing tissue inflammation. Our data confirms that kombucha tea effectively improves inflammatory conditions by suppressing the expression of cytokines and proinflammatory responses induced by lipid storage droplet‐1 dysfunction. It was found that kombucha tea consumption alleviated the production of reactive oxygen species and activated the JNK signaling pathway, signifying its potential as an anti‐inflammatory agent against systemic inflammatory responses connected to the JNK pathway. Kombucha tea reduced triglyceride accumulation by increasing the activity of Brummer (a lipase), thereby promoting lipolysis in third‐instar larvae. Therefore, kombucha tea could be developed as a novel, functional beverage to protect against obesity and inflammation. Our study also highlights the potential use of this innovative model to evaluate the effects of bioactive compounds derived from natural products.
Managing risk and reaping rewards: Climate‐change futures as a game‐changer for energy futures markets
Authors: Hoque Mohammad Enamul , Kabir Hassan M. , Pezzo Luca
Published: May 2024

Climate‐change futures provide a platform for low‐carbon portfolios and energy market risk hedging. Climate changes induce uncertainty in energy‐commodity markets. We investigate the potential of diversifying and hedging energy‐commodity market risk with climate‐change futures, using dynamic conditional correlation (DCC)‐ordinary least squares (OLS) incorporating quantile‐dummies and cross‐quantilogram (CQ) approaches. DCC‐OLS models reveal that the World and USA climate‐change futures exhibit that they can be diversifiers for oil, ethanol, gasoil, and gasoline. These futures also exhibit hedging features for natural gas, coal, and heating oil. Euro climate‐change futures demonstrate hedging capabilities for all energy commodities except oil and gasoil. World, USA, and Euro climate‐change futures have the potential to serve as safe‐haven financial instruments in the face of the high volatility of Brent crude oil, gasoil, and heating oil. The CQ reveals that World, USA, and Euro climate‐change futures exhibit hedging and safe‐haven capacity against oil, natural gas, coal, gasoil, gasoline, and heating futures. Climate‐change futures may protect financial investments during extreme volatility in energy commodities.
Suicidal behavior and all‐cause mortality in depressed older adults aged 75+ treated with electroconvulsive therapy: A Swedish register‐based comparison study
Authors: Hedna Khedidja , Jonson Mattias , Sigström Robert , Levinsson Anna , Nordenskjöld Axel , Waern Margda
Published: May 2024

Objectives

Electroconvulsive therapy (ECT) is effective in treating late‐life depression. There is limited research on suicidal behavior and all‐cause mortality in the oldest old after ECT.

Methods

Older adults aged 75 years and above who had been inpatients for moderate to severe depression between January 1, 2011, and December 31, 2017, were included in the study. We used exact and propensity score matching to balance groups. We compared suicidal behavior (fatal and non‐fatal) and all‐cause mortality in those who had received ECT and those with other depression treatments.

Results

Of the study population, 1802 persons who received ECT were matched to 4457 persons with other treatments. There were no significant differences in the risk of suicidal behavior between groups, (within 3 months: odds ratio 0.73; 95% confidence intervals (CI), 0.44–1.23, within 4 months to 1 year: aOR 1.34; 95% CI, 0.84–2.13). All‐cause mortality was lower among ECT recipients compared to those who had received other treatments, both within 3 months (aOR, 0.35; 95% CI, 0.23–0.52), and within 4 months to 1 year (aOR 0.65; 95% CI, 0.50–0.83).

Conclusions

Compared to other depression treatments, ECT is not associated with a higher risk of suicidal behavior in patients aged 75 and above. ECT is associated with lower all‐cause mortality in this age group, but we advise caution regarding causal inferences.
‘Black Out Rage Gallon’ (aka borg): An investigation of a risky drinking trend on TikTok
Authors: Mandzufas Joelie , Lim Natalie , McPhie Skye , Martin Craig , Johnston Robyn S. , Lombardi Karen , Trapp Gina S. A.
Published: May 2024

Issue Addressed

A ‘Black Out Rage Gallon’ (borg) is a customised, individual alcoholic beverage popularised on TikTok, whereby half the water in a gallon jug is replaced with alcohol (usually spirits), flavourings, electrolytes and caffeine. We investigated the characteristics and portrayal of the emerging alcohol trend associated with the hashtag descriptor #borg on TikTok.

Methods

We identified highly viewed TikTok videos with the #borg hashtag (n = 103) and conducted a content analysis, capturing viewer engagement (‘likes’, shares, comments), techniques used, characteristics of featured individuals, and the portrayal of alcohol and risky drinking behaviours.

Results

Alcohol was visible in three quarters of the videos analysed (n = 78, average amount of alcohol present 865 mL per borg) and consumed in one third of the videos (n = 34). One quarter of videos (n = 25) promoted alleged benefits of borg consumption compared to other alcohol products or approaches to drinking, yet only nine videos included a warning about potential harms.

Conclusions

The borg trend on TikTok may encourage risky drinking, by portraying it in a style that younger viewers are likely to see as fun and entertaining.

So What?

We were able to gain a better understanding of how this potentially health harming activity is represented on a social media platform that is popular with young people. The speedy dissemination of this trend highlights the need to monitor, investigate and counter emerging trends. Concurrently, there is an urgent need for content restrictions to limit the visibility and promotion of risky alcohol consumption on TikTok.
TTF1 control of LncRNA synthesis delineates a tumor suppressor pathway directly regulating the ribosomal RNA genes
Authors: Sibai Dany S. , Tremblay Michel G. , Lessard Frédéric , Tav Christophe , Sabourin‐Félix Marianne , Robinson Mark , Moss Tom
Published: May 2024

The tumor suppressor p14/19ARF regulates ribosomal RNA (rRNA) synthesis by controlling the nucleolar localization of Transcription Termination Factor 1 (TTF1). However, the role played by TTF1 in regulating the rRNA genes and in potentially controlling growth has remained unclear. We now show that TTF1 expression regulates cell growth by determining the cellular complement of ribosomes. Unexpectedly, it achieves this by acting as a “roadblock” to synthesis of the noncoding LncRNA and pRNA that we show are generated from the “Spacer Promoter” duplications present upstream of the 47S pre‐rRNA promoter on the mouse and human ribosomal RNA genes. Unexpectedly, the endogenous generation of these noncoding RNAs does not induce CpG methylation or gene silencing. Rather, it acts in cis to suppress 47S preinitiation complex formation and hence de novo pre‐rRNA synthesis by a mechanism reminiscent of promoter interference or occlusion. Taken together, our data delineate a pathway from p19ARF to cell growth suppression via the regulation of ribosome biogenesis by noncoding RNAs and validate a key cellular growth law in mammalian cells.
Ten different viral agents infecting and co‐infecting children with acute gastroenteritis in Southern Italy: Role of known pathogens and emerging viruses during and after COVID‐19 pandemic
Authors: Amoroso Maria Grazia , Pucciarelli Alessia , Serra Francesco , Ianiro Giovanni , Iafusco Michele , Fiorito Filomena , Polverino Maria Grazia , Dimatteo Maria , Monini Marina , Ferrara Daniela , Martemucci Luigi , Di Bartolo Ilaria , De Carlo Esterina , Fusco Giovanna
Published: May 2024

Acute gastroenteritis (AGE) represents a world public health relevant problem especially in children. Enteric viruses are the pathogens mainly involved in the episodes of AGE, causing about 70.00% of the cases. Apart from well‐known rotavirus (RVA), adenovirus (AdV) and norovirus (NoV), there are various emerging viral pathogens potentially associated with AGE episodes. In this study, the presence of ten different enteric viruses was investigated in 152 fecal samples collected from children hospitalized for gastroenteritis. Real time PCR results showed that 49.3% of them were positive for viral detection with the following prevalence: norovirus GII 19.7%, AdV 15.8%, RVA 10.5%, human parechovirus (HPeV) 5.3%, enterovirus (EV) 3.3%, sapovirus (SaV) 2.6%. Salivirus (SalV), norovirus GI and astrovirus (AstV) 1.3% each, aichivirus (AiV) found in only one patient. In 38.2% of feces only one virus was detected, while co‐infections were identified in 11.8% of the cases. Among young patients, 105 were ≤5 years old and 56.0% tested positive for viral detection, while 47 were >5 years old with 40.0% of them infected. Results obtained confirm a complex plethora of viruses potentially implicated in gastroenteritis in children, with some of them previously known for other etiologies but detectable in fecal samples. Subsequent studies should investigate the role of these viruses in causing gastroenteritis and explore the possibility that other symptoms may be ascribed to multiple infections.
Infant formulas for the treatment of functional gastrointestinal disorders: A position paper of the ESPGHAN Nutrition Committee
Authors: Haiden Nadja , Savino Francesco , Hill Susan , Kivelä Laura , De Koning Barbara , Kӧglmeier Jutta , Luque Veronica , Moltu Sissel J. , Norsa Lorenzo , De Pipaon Miguel Saenz , Verduci Elvira , Bronsky Jiri
Published: May 2024

Functional gastrointestinal disorders (FGID), such as infant regurgitation, infant colic, and functional constipation, are common and typically physiological phenomena during the early months of an infant's life and account for frequent consultations with pediatricians. Various infant formulas are marketed for their management and are frequently given by parents to infants before a medical consultation. However, the evidence supporting their effectiveness is limited and some have altered nutritional compositions when compared to standard formulas. Thus, these products should only be used under medical supervision and upon medical advice. Marketing and over‐the‐counter sales do not ensure proper medical guidance and supervision. The aim of this position paper is to review the current evidence regarding the safety and efficacy of formulas specifically formulated for addressing regurgitation, colic, and constipation, recognized as FGID. The objective is to provide guidance for clinical management based on the highest quality of available evidence. A wide search using Pubmed, MEDLINE, EMBASE and Cochrane Database of Systematic Reviews was performed including the MESH terms infant formula, colic, constipation, regurgitation, reflux, palmitate, lactase, lactose, magnesium, hydrolyzed protein, prebiotics or probiotics. 752 papers were identified and screened. Finally, 72 papers were included in the paper. In the absence of evidence, recommendations reflect the authors' combined expert opinion. Final consensus was obtained by multiple e‐mail exchange and meetings of the Nutrition Committee. (1) For breastfed infants experiencing FGID such as regurgitation, colic, or constipation, transitioning from breastfeeding to commercial formulas is not recommended. (2) In general, whether an infant is breastfed or formula‐fed, it's crucial to reassure parents that FGIDs are normal and typically do not necessitate treatment or change to a special formula. (3) Thickened formulas, often termed anti‐reflux formulas, may be considered in specific cases of regurgitation. (4) The usage of specialized formulas for infants with colic is not advised due to a lack of clinical evidence. (5) In the case of constipation in infants, the use of formulas enriched with high β‐palmitate and increased magnesium content may be considered to soften the stool. Generally, there is limited evidence supporting the use of specialized formulas for FGID. Breastfeeding should never be discontinued in favor of formula feeding.
Acupuncture treatment for liver cancer pain: A meta‐analysis
Authors: He Yi , Xiang Shate , Zhang Danjun , Chen Muzhi
Published: May 2024

Acupuncture treatment is a common intervention for the clinical relief of primary liver cancer (PLC) pain, but there is variability in its efficacy. This review systematically assessed the efficacy and safety of acupuncture treatment for PLC pain by meta‐analysis. A total of 17 randomized controlled trial studies involving 1162 patients met the inclusion criteria. This study identified the acupuncture method, treatment duration, and patient age were the main factors affecting the efficacy of acupuncture treatment.
Ultra‐Power‐Efficient, Electrically Programmable, Multi‐State Photonic Flash Memory on a Heterogeneous III‐V/Si Platform
Authors: Cheung Stanley , Liang Di , Yuan Yuan , Peng Yiwei , Tossoun Bassem , Hu Yingtao , Xiao Xian , Sorin Wayne V. , Kurczveil Geza , Beausoleil Raymond G.
Published: May 2024

Non‐volatile charge‐trap flash memory (CTM) co‐located with heterogeneous III‐V/Si photonics is demonstrated. The wafer‐bonded III‐V/Si CTM cell facilitates non‐volatile optical functionality for a variety of devices such as Mach–Zehnder Interferometers (MZIs), asymmetric MZI lattice filters, and ring resonator filters. The MZI CTM exhibits full write/erase operation (100 cycles with 500 states) with wavelength shifts of Δλnon‐volatile = 1.16 nm (Δneff,non‐volatile ≈ 2.5 × 10−4) and a dynamic power consumption <20 pW (limited by measurement). Multi‐bit write operation (2 bits) is also demonstrated and verified over a time duration of 24 h and most likely beyond. The cascaded second order ring resonator CTM filter exhibited an improved ER of ≈7.11 dB compared to the MZI and wavelength shifts of Δλnon‐volatile = 0.041 nm (Δneff, non‐volatile = 1.5 × 10−4) with similar pW‐level dynamic power consumption as the MZI CTM. The ability to co‐locate photonic computing elements and non‐volatile memory provides an attractive path toward eliminating the von‐Neumann bottleneck.