bluuebunny/crossref_metadata_2025 huggingface dataset:
Transcriptomic analysis reveals differential gene expression, alternative splicing, and novel exons during mouse trophoblast stem cell differentiation
Authors: Ullah Rahim , Naz Ambreen , Akram Hafiza Sara , Ullah Zakir , Tariq Muhammad , Mithani Aziz , Faisal Amir
Published: August 2020

Background

Differentiation of mouse trophoblast stem cells (TSCs) to trophoblast giant cells (TGCs) has been widely used as a model system to study placental development and function. While several differentially expressed genes, including regulators of TSC differentiation, have been identified, a comprehensive analysis of the global expression of genes and splice variants in the two cell types has not been reported.

Results

Here, we report ~ 7800 differentially expressed genes in TGCs compared to TSCs which include regulators of the cell cycle, apoptosis, cytoskeleton, cell mobility, embryo implantation, metabolism, and various signaling pathways. We show that several mitotic proteins, including Aurora A kinase, were downregulated in TGCs and that the activity of Aurora A kinase is required for the maintenance of TSCs. We also identify hitherto undiscovered, cell-type specific alternative splicing events in 31 genes in the two cell types. Finally, we also report 19 novel exons in 12 genes which are expressed in both TSCs and TGCs.

Conclusions

Overall, our results uncover several potential regulators of TSC differentiation and TGC function, thereby providing a valuable resource for developmental and molecular biologists interested in the study of stem cell differentiation and embryonic development.
[18F]FEPPA PET imaging for monitoring CD68-positive microglia/macrophage neuroinflammation in nonhuman primates
Authors: Zammit Matthew , Tao Yunlong , Olsen Miles E. , Metzger Jeanette , Vermilyea Scott C. , Bjornson Kathryn , Slesarev Maxim , Block Walter F. , Fuchs Kerri , Phillips Sean , Bondarenko Viktorya , Zhang Su-Chun , Emborg Marina E. , Christian Bradley T.
Published: August 2020

Purpose

The aim of this study was to examine whether the translocator protein 18-kDa (TSPO) PET ligand [18F]FEPPA has the sensitivity for detecting changes in CD68-positive microglial/macrophage activation in hemiparkinsonian rhesus macaques treated with allogeneic grafts of induced pluripotent stem cell-derived midbrain dopaminergic neurons (iPSC-mDA).

Methods

In vivo positron emission tomography (PET) imaging with [18F]FEPPA was used in conjunction with postmortem CD68 immunostaining to evaluate neuroinflammation in the brains of hemiparkinsonian rhesus macaques (n = 6) that received allogeneic iPSC-mDA grafts in the putamen ipsilateral to MPTP administration.

Results

Based on assessment of radiotracer uptake and confirmed by visual inspection of the imaging data, nonhuman primates with allogeneic grafts showed increased [18F]FEPPA binding at the graft sites relative to the contralateral putamen. From PET asymmetry analysis of the images, the mean asymmetry index of the monkeys was AI = − 0.085 ± 0.018. Evaluation and scoring of CD68 immunoreactivity by an investigator blind to the treatment identified significantly more neuroinflammation in the grafted areas of the putamen compared to the contralateral putamen (p = 0.0004). [18F]FEPPA PET AI showed a positive correlation with CD68 immunoreactivity AI ratings in the monkeys (Spearman’s ρ = 0.94; p = 0.005).

Conclusion

These findings reveal that [18F]FEPPA PET is an effective marker for detecting increased CD68-positive microglial/macrophage activation and demonstrates sufficient sensitivity to detect changes in neuroinflammation in vivo following allogeneic cell engraftment.
Is hypoxemia explained by intracardiac or intrapulmonary shunt in COVID-19-related acute respiratory distress syndrome?
Authors: Masi Paul , Bagate François , d’Humières Thomas , Al-Assaad Lara , Abou Chakra Laure , Derumeaux Genevieve , Mekontso Dessap Armand
Published: August 2020

Hypoxemia is the main feature of COVID-19-related acute respiratory distress syndrome (C-ARDS), but its underlying mechanisms are debated, especially in patients with low respiratory system elastance (Ers). We assessed 60 critically ill patients hospitalized in our intensive care unit for C-ARDS. We used contrast transthoracic echocardiography to assess patent foramen ovale (PFO) shunt and transpulmonary bubble transit (TPBT). The median Ers was 32 cmH2O/L. PFO shunt was detected in six (10%) patients and TPBT in 12 (20%) patients. PFO shunt and TPBT were similar in patients with higher or lower Ers. In conclusion, PFO and TPBT do not seem to be the main drivers of hypoxemia in C-ARDS, especially in patients with lower Ers.
Spin Crossover between the High-Spin and Low-Spin States and Dielectric Switching in the Ionic Crystals of a Fe(II) [2 × 2] Molecular Grid
Authors: Uezu Yuta , Tsunashima Ryo , Tanaka Chiaki , Fujibayashi Masaru , Manabe Jun , Nishihara Sadafumi , Inoue Katsuya
Published: August 2020

We synthesized an Fe(II) [2 × 2] molecular grid with pyridyl-substituted bis-terdentate ligands. The molecular grid showed abrupt spin crossover between fully high-spin and fully low-spin states in a narrow temperature width of ∼10 K. The spin crossover event also included a first-order structural phase transition, in which the dielectric constant jumped atypically toward a low-spin state.
Hedge Fund Franchises
Authors: Fung William , Hsieh David , Naik Narayan , Teo Melvyn
Published: August 2020

We investigate the growth strategies of hedge fund firms. We find that firms with successful first funds are able to launch follow-on funds that charge higher performance fees, set more onerous redemption terms, and attract greater inflows. Motivated by the aforementioned spillover effects, first funds outperform follow-on funds, after adjusting for risk. Consistent with the agency view, greater incentive alignment moderates the performance differential between first and follow-on funds. Moreover, multiple-product firms underperform single-product firms but harvest greater fee revenues, thereby hurting investors while benefitting firm partners. Investors respond to this growth strategy by redeeming from first funds of firms with follow-on funds that do poorly. Empirically, the multiple-product firm has become the dominant business model for the hedge fund industry.

This paper was accepted by Tyler Shumway, finance.
Robustness to misalignment of low-cost, compact quantitative phase imaging architectures
Authors: Fitzpatrick Catherine R. M. , Wilson Abby , Sawyer Travis W. , Christopher Peter J. , Wilkinson Timothy D. , Bohndiek Sarah E. , Gordon George S. D.
Published: August 2020

Non-interferometric approaches to quantitative phase imaging could enable its application in low-cost, miniaturised settings such as capsule endoscopy. We present two possible architectures and both analyse and mitigate the effect of sensor misalignment on phase imaging performance. This is a crucial step towards determining the feasibility of implementing phase imaging in a capsule device. First, we investigate a design based on a folded 4f correlator, both in simulation and experimentally. We demonstrate a novel technique for identifying and compensating for axial misalignment and explore the limits of the approach. Next, we explore the implications of axial and transverse misalignment, and of manufacturing variations on the performance of a phase plate-based architecture, identifying a clear trade-off between phase plate resolution and algorithm convergence time. We conclude that while the phase plate architecture is more robust to misalignment, both architectures merit further development with the goal of realising a low-cost, compact system for applying phase imaging in capsule endoscopy.
Preface
Authors: Ryk-Lakhman Ira , Nuridzhanian Gaiane
Published: August 2020

The 2017 UCL Laws Postgraduate and Early Career Conference was held on 30-31 March 2017 in London. The theme of the Conference, ‘The Art of Balancing: The Role of Law in Reconciling Competing Interests’, sought to explore the challenges arising from the need to balance competing rights, obligations, and freedoms. The growing focus on States’ obligations to respect and protect human rights and freedoms has led to a shift in the manner States conduct themselves both in the domestic and international arenas. Yet, given the ever increasing extent of international regulation and concomitant demands on limited financial, technical and human resources, it is not at all clear how these competing rights and obligations ought to be balanced. These questions, and many others, were explored by some 25 practitioners and academics during the two-day event. Several of those works were selected to feature in this special issue.
Potenzialità glottodidattiche della comunicazione pubblicitaria
Authors: Marcello Marcello
Published: August 2020

The aim of the present article is to shed the light on educational aspects which can be obtained by the exploration of an authentic, advertising material. The analysis attempts to demonstrate how communicative and linguistic characteristics, argumentative patterns, rhetorical figures and cultural aspects, which constitute the complex structure which is advertising message, convey values, stereotypes, social and linguistic tendencies. All of the above are conceived in order to complete the goals of persuasion. For the teacher, it is a rich, authentic and precious resource which gives the student the opportunity to extend his abilities and skills, to face and approach a new, linguistic and cultural context.
Ausiliari del passivo nella didattica dell’italiano LS
Authors: Grochowska-Reiter Anna
Published: August 2020

This article attempts to examine the passive auxiliaries in modern Italian and how they are presented to the Italian language learners. A growing body of research has been throwing light on the fact that the passive auxiliaries are not only the canonical essere and venire, but also andare, which is open to a twofold interpretation («modal passive» and «loss passive»), as well as rimanere, restare, trovarsi, vedersi and finire. In view of this, the analysis of syllabi of Italian L2 and of Italian grammar books has been carried out. The analysis of seven syllabi has confirmed the tendency to introduce the passive voice at B2 level. As far as auxiliaries are concerned, the syllabi refer explicitly to five: essere, venire, andare, restare andrimanere. The second analysis, carried out on sixteen grammar textbooks for Italian language learning, has shown some weakness regarding the teaching of passive auxiliaries, such as a) lack of any semantic differentiation between use of essere and venire; b) a certain selectivity in presenting aspects of the remainder of auxiliaries (andare, rimanere, vedersi, trovarsi and finire are rarely presented in their entirety); c) various theoretical disagreements in the presentation of the rules that guide the use of passive auxiliaries.
L’insegnamento della cortesia come elemento della competenza comunicativa nei manuali d’italiano LS: sfide e soluzioni
Authors: Miłkowska-Samul Kamila
Published: August 2020

The aim of this paper is to address the issue of teaching politeness in textbooks dedicated to learners of Italian as a foreign language. It is assumed that in today’s ever-changing world, full of conflicts and challenges of various kinds, polite communication has become of increasing importance as it helps overcome differences between the participants of the act of communication and promote a peaceful coexistence. Politeness is a phenomenon particularly sensitive to the situational context: the forms considered appropriate vary according to the parameters such as place, channel, age or status of the interactants. Since the complexity of politeness and the variability of its exponents make it difficult to teach, the purpose of this research is to analyze if and how the current textbooks of Italian deal with this aspect of communicative competence. The paper examines which aspects of politeness are taught and with what methods. The analysis is based on the selected textbooks of Italian published in Italy and Poland, in order to compare their approaches.
Transculturar el debate. Los desafíos de la crítica literaria latinoamericana actual en dos escritoras: Mariana Enriquez y Liliana Colanzi
Authors: Amatto Alejandra
Published: August 2020

Resumen: Este artículo discute la necesidad de establecer nuevas herramientas analíticas que acompañen los procesos interpretativos de la literatura latinoamericana actual. Se parte de la concepción de un nuevo momento en nuestras letras que debe contar con un soporte crítico a la altura de sus necesidades. Para ello, se pretende desmontar la definición clásica de transculturación, empleada por el cubano Fernando Ortiz y retomada por el uruguayo Ángel Rama, con la intención de estructurar una categoría operativa denominada: literaturas del descontento realista. Esta designación permitirá acercarse a las obras de las narradoras Mariana Enriquez y Liliana Colanzi, con la finalidad de ejemplificar en el análisis de dos de sus cuentos la propuesta formulada. Asimismo, el artículo pretende reflexionar sobre algunas de las variaciones de la crítica latinoamericana frente a su posición con respecto a las literaturas de irrealidad y la literatura realista actuales.

 

Palabras clave: teoría literaria, Latinoamérica, nuevas narrativas, Enriquez, Colanzi.
Porfirio Barba Jacob: la ira sostenida
Authors: Solórzano Esqueda Lilia
Published: August 2020

En este artículo se revisan algunas constantes entre la personalidad del escritor Porfirio Barba Jacob, algunos momentos de su poesía y el tono en los contenidos de su trabajo periodístico. El ánimo acre y furibundo sirve como hilo conductor que permite dar cuenta de su forma de estar en el mundo: airada y rebelde. Y revela, a la distancia, la importancia de ciertos juicios políticos.
ОЦІНКА РИЗИКУ В УПРАВЛІННІ РОЗВИТКОМ ГОТЕЛЬНОГО БІЗНЕСУ
Authors: ЗАВІДНА Людмила
Published: August 2020

В умовах нестабільної, швидко мінливої ситуації необхідно враховувати всі можливі наслідки зміни кон'юнктури ринку, в тому числі і дій конкурентів. Висока міра ризику приводить до необхідності пошуку шляхів штучного зниження можливих наслідків впливу ризику на зміну умов реалізації функціонування бізнесу. Тому основне призначення оцінки ризику полягає у забезпеченні власників бізнесу інформацією, необхідною для прийняття відповідних рішень, а також у передбаченні заходів щодо захисту від можливих втрат.Гнучка система фінансового менеджменту на підприємстві готельного бізнесу має оперативно реагувати на будь-які зміни в його діяльності, що особливо актуально в сучасних умовах і практично неможливо без використання ефективних методів оцінки ризику банкрутства. Для прогнозування кризи та оцінки можливого банкрутства підприємств готельного бізнесу, визначення рівня ризику здійснено оцінку фінансового стану 21 підприємства готельного господарства з 10 областей України (Вінницької, Волинської, Дніпропетровської, Закарпатської, Львівської, Тернопільської, Харківської, Херсонської, Хмельницької, Чернігівської) та Києва за 2015 р. з використанням п’ятифакторної моделі Альтмана.У ході оцінки стратегії готельних підприємств за даною моделлю було визначено, що, з урахуванням наявних умов ризику, більшість досліджуваних підприємств реалізують стратегії не досить ефективно. Економічний потенціал відповідних підприємств є низьким, а ризик банкрутства – високим. У трьох готельних підприємств одержано показники наближені до нормативу, тобто їх стратегію розвитку можна вважати задовільною.Для запобігання банкрутству підприємствам готельного бізнесу з високим ризиком пропонуємо впроваджувати фінансові інструменти, які б дозволяли відшкодовувати збитки в разі виникнення ризикових подій.Зростання вартості бізнесу буде максимальним, якщо менеджмент сформує стратегію і поставить цілі для досягнення балансу в тріаді "зростання компанії – прибутковість – ризики", але при цьому необхідно ефективно використовувати наявні ресурси.
BOOK TRAILERS NA EDUCAÇÃO PROFISSIONAL E TECNOLÓGICA: UM ESTUDO COM DISCENTES DO CURSO DE COMPUTAÇÃO GRÁFICA DO IFPE – CAMPUS OLINDA
Authors: Almeida Lucas Rodrigo Santos de , Cordeiro Eugênia de Paula Benício
Published: August 2020

Este artigo tem como objetivo geral investigar como a criação de book trailers, por discentes do Curso Técnico de Computação Gráfica do Instituto Federal de Pernambuco – Campus Olinda, pode contribuir para o estímulo à leitura em uma perspectiva de formação profissional e tecnológica. Metodologicamente a pesquisa dividiu-se em: bibliográfica, documental e pesquisa de campo no IFPE – Campus Olinda. Em relação à natureza, é de cunho exploratório, qualitativo e propositivo, utilizando como estratégia de pesquisa a pesquisa-ação. Quanto à técnica de análise e discussões dos dados, foi utilizada a abordagem interpretativa. Ao final, de acordo com os achados teóricos e empíricos, comprovou-se que o book trailer é uma ferramenta lúdica, emotiva e inovadora, no qual pode estimular o interesse, a curiosidade e o hábito da leitura para o sujeito-leitor.
AMBIENTE DE SERVICIO Y CALIDAD PERCIBIDA DE UNA IES (INSTITUCIÓN DE EDUCACIÓN SUPERIOR) PRIVADA EN BOGOTÁ
Authors: Fallla Lina
Published: August 2020

Brindar servicios de calidad en el ámbito educativo tiene gran importancia para que el sistema educativo del país pueda lograr el objetivo trazado a 2025 de tener una Colombia más educada. En la literatura tanto internacional como nacional, se encuentran investigaciones orientadas a evaluar la calidad del servicio educativo, así como el nivel de satisfacción de los estudiantes. Sin embargo, estas evaluaciones suelen centrarse en el proceso educativo (en la formación como tal), más que en las experiencias asociadas a la vinculación a la educación superior. Así mismo, no se encuentran muchos estudios enfocados a las necesidades, expectativas y percepciones de los estudiantes con respecto a la formación que van a recibir a partir del servicio que han recibido. El ambiente de servicio involucra variables físicas, simbólicas, sociales y naturales, con las cuales los sujetos entran en contacto en el momento de buscar un servicio. Esto se conoce como el ambiente de servicio ampliado.

Teniendo en cuenta lo anterior, el presente trabajo busca encontrar si el ambiente de servicio ampliado se relaciona con la percepción de calidad en el servicio de atención a nuevos estudiantes de educación superior. Para poder encontrar esta relación, se propone un estudio en tres fases. La primera: observación de la sala de atención. La segunda: entrevistas en profundidad con usuarios de la sala de atención para identificar las variables del ambiente de servicio ampliado asociadas a calidad. Y tercera: medición de las variables identificadas y su influencia en la percepción de calidad.  
IMPLEMENTAÇÃO DO MÉTODO ÁGIL COM A UTILIZAÇÃO DA PLATAFORMA TRELLO NO GERENCIAMENTO DE PROJETOS EDUCACIONAIS
Authors: Da Ramada Isabella Anderson , Scafuto Isabel Cristina
Published: August 2020

Este relato técnico aborda o denominado enfoque na melhoria, em que é reportada uma experiência profissional com aplicação na prática de uma nova solução para problemas identificados no processo ensino-aprendizagem frente a um grupo de 48 alunos pertencentes ao curso de Publicidade & Propaganda de uma grande Instituição de Ensino Superior de São Paulo, capital. Como objetivo, o presente estudo visa apresentar a implementação da metodologia ágil com uso de uma plataforma digital para o gerenciamento de projetos educacionais junto ao grupo de estudo. A abordagem adotada foi a qualitativa e com uso do método de pesquisa-ação que por sua vez contemplou as fases de planejamento, ação e observação e, por fim, os resultados. Com a utilização da metodologia ágil de gerenciamento de projetos e uso da plataforma proposta os resultados obtidos foram plenamente satisfatórios e o projeto despertou o interesse de outros coordenadores de cursos.
MUNDO SEM FIM: A CONVERSÃO RELIGIOSA EM THINGS FALL APART E NO LONGER AT EASE, DE CHINUA ACHEBE
Authors: Paradiso Silvio Ruiz , Soares Emanoel Lima Silva
Published: August 2020

Ao retratar o período histórico da colonização na Nigéria, o escritor Chinua Achebe revela a função ideológica da pregação cristã, que coaduna com o propósito do império britânico: dominação cultural, política e social. Neste artigo, refletimos sobre a conversão religiosa por meio da análise de dois romances pós-coloniais: Things fall apart (1958) e No longer at ease (1960).
The analysis of spatio-temporal features of microbiological and hydrochemical indicators of the rivers within Surgutsky and Oktyabrsky Districts in Khanty-Mansi Autonomous Okrug – Yugra
Authors: Arslanova Marina M. , Shornikova Elena A. , Muzieva Madina I.
Published: August 2020

The study of the environmental situation in river basins, including the assessment of actual water pollution, has recently become relevant. Water bodies located within the borders of oil production territories are experiencing constant and intense anthropogenic impact, which occurs not only during the operation of fields, but also during the preparation of areas for exploration and production drilling, construction of multi-well pads, communications, etc. This paper analyzes peculiarities of microbiological and hydrochemical indicators distribution of the rivers within Surgutsky and Oktyabrsky Districts in Khanty-Mansi Autonomous Okrug Yugra. The cluster analysis method determines cascade systems based on the total microbial number of the studied rivers. The characteristics of the generic composition and distribution of the identified microorganisms are given. As a result of the cluster analysis, it was revealed that organoheterotrophic microflora is found mainly in the studied rivers. 16 bacterial cultures and 3 cultures from the mycelial microflora were identified among the isolated microorganisms. The paper also presents the results of rivers monitoring in 20182019 on the following water quality indicators: pH, ammonium ions and acute toxicity. The time variability of hydrochemical indicators correlates with different phases of the hydrological regime of rivers.
The state of vegetation in the landscaping system of Ulan-Ude
Authors: Ievskaya Alena A. , Korsunova Tatyana M.
Published: August 2020

This paper presents the results of the study of squares vegetation ecological state in Ulan-Ude based on the results of green spaces inventory (20162018). The data were obtained on the species diversity and structure of urban green spaces. The families of Rosaceae (12) and Pinaceae (5) are represented to the greatest extent in the studied squares. In quantitative terms plantations of squat elm (Ulmus pumila L.), balsam poplar (Populus balsamifera L.), ash maple (Acer negundo L.) and berry apple (Malus baccata (L.) Borkh.) predominated in the squares of Ulan-Ude. The analysis of the assortment composition of Ulan-Ude squares showed that it was quite poor. The age structure of existing plantations on the territory of the studied squares varies widely; a significant part of the plantations is approaching the age of its physiological old age. During the research period the quality of flower beds and lawns was assessed at landscaping facilities. At the present moment their condition is improving due to the improvement in the quality of nursing work. An indicator of the total projective cover was determined at the grassy layer. The obtained data on the vegetation state indicate that the state of plantings is weakening in most of the studied squares. The study results can serve as the basis for further monitoring of Ulan-Ude green areas.
Comparative ecological and physiological characteristics of Penicillium chrysogenum Thom 1910 strains found on the territory of Surgut
Authors: Mantrova Maria V.
Published: August 2020

The paper deals with ecological and physiological properties of four strains of the species Penicillium chrysogenum Thom 1910, taken on the territory of Surgut from soil, water and the surface of synthetic polymers, depending on the source of carbon nutrition and temperature. The author also considers phytotoxic properties of these strains in relation to several test objects. The cultural and morphological characteristics of the strains are similar to each other in places with sucrose, lactose, mannitol, starch and cellulose, and are variable in places with sorbitol and glycerol. The highest average values of the radial growth rate were recorded in places with alcohols sorbitol and glycerine. General cultural and morphological characteristics are typical for strains when cultivated in the same temperature regime; a low temperature of +5C contributes more to the growth of colonies than a high temperature of +37C, the optimal one is +25C; the obtained data confirm that P. chrysogenum belongs to mesophilic (psychrotolerant) species. All strains are toxic to radish seedlings; variably toxic to wheat seedlings, Canada water weed and duckweed and non-toxic to wheat and radish seeds. The obtained results can be used for studying the ecology of P. chrysogenum strains, as well as for identifying this species.
Organization, state and activity of criminal investigation units intelligence work in the Middle Volga Region in the first half of the 1920s
Authors: Gazatulin Shamil T.
Published: August 2020

The paper reflects the issues of formation and development of the agency work of state security and law enforcement agencies in the first half of the 1920s. The author considers the process of operational work formation of the criminal investigation department. Legal documents regulating the secret work of the Cheka and NKVD bodies are also considered. The categories of criminal investigation agents, the requirements imposed on them, the rules for building and controlling covert work, and the amount of funding are specified. Development and formation of the secret work of central and local criminal investigation institutions is traced on the example of the provincial criminal investigation departments of the Middle Volga region. On the basis of archival documents, the complexity and unevenness of this process in the regions are noted; the main problems (organizational, personnel and material) and the measures taken to eliminate them and improve the secret work are reflected. Materials of all-Russian congresses of NKVD territorial bodies heads show that much attention was paid to the organization of intelligence and operational work. The practical significance of covert work on the activities of the criminal investigation department is considered. The author has analyzed the influence of the received agent information by the Penza provincial department of criminal investigation on the activity of solving crimes in the second half of 1922.
Facilitative orientation of continuing education courses as a means of preschool teachers’ professional competence development
Authors: Bakhicha Eleonora E.
Published: August 2020

The paper discusses the features of implementation of additional professional training programs for preschool teachers. The author reveals a facilitative approach in organizing and teaching classes as models of a teacher and students relationship, based on care, organization and encouragement of teachers process of self-development. The paper describes two types of facilitation: social facilitation, which is seen as facilitating or reinforcing influence of social factors on the quality of the individual performance in the learning process, and pedagogical facilitation as a synergy (cooperation), the interdependence of the teacher and the group taking into account each students personal autonomy. The essence of pedagogical facilitation of additional professional education is presented as an active job in the group, as a result of which students will be able to analyze the problem and to make unconventional decision as professionals. In this regard, the task of the teacher is to involve students in the educational process and to share some managerial functions with the aim of creating conditions for a revival of deep interest to the subject (module) and promoting positive attitude to educational activity. Facilitative orientation of training courses for preschool teachers includes: creating conditions for a positive mood and understanding of prospects of professional improvement and personal growth; getting specific educational product that can move to a situation of professional activity (project, program, technology, etc.); providing prospects for further progress opportunities in the area of professional activities.
Testicular microlithiasis in male infertility: prevalence, diagnosis and treatment algorithm
Authors: Korneyev Igor A. , Zasseev Ruslan D. , Aloyan Aram A. , Grinina Anastasia A. , Kondrashkin Pavel S. , Makeev Vladimir A. , Furin Valeriy E.
Published: August 2020

Aim of study. To estimate testicular microlithiasis (TM) prevalence in men seeking help for infertility in reproductive medicine center, and generate an algorithm for TM management according to patients choice to perform testicular biopsy or not.
Materials and methods. We retrospectively reviewed charts of 143 consecutive adult male patients between 19 and 73 years (mean age 34.6 7.9) seeking help for infertility in International Center for Reproductive Medicine. Gray-scale and color Doppler were used to calculate testicular volume and to study a spectrum of scrotal disorders including testicular microlithiasis.
Results. Testicular size varied from 0.5 to 33.3 ml (mean 12.3 5.8 ml), testicular hypoplasia, varicocele, hydrocele and epididymal cysts were detected in 88 (61.5%), 35 (24.5%), 9 (6.3%) and 50 (35%) patients respectively. TM signs were identified in 12 (8.4%) men, including 5 (42%) cases of classic TM and 7 (58%) cases of limited TM; 5 (42%) men had bilateral TM. One 1 (8%) patient with bilateral ТМ had ultrasonic appearance of non-palpable testicular tumor, radical surgical treatment was performed. Patients with TM had smaller testicles, higher prevalence of azoospermia and testicular tumor (p = 0.002, 0.013 and 0.085 respectively). All patients with TM were informed about their risks to harbor testicular cancer and taught self-examination technique. Testicular biopsy was offered to all men with concomitant risk factors for testicular cancer development, however none of the patients agreed. We have consequently developed algorithm for TM management according to patients choice to perform or to avoid testicular biopsy.
Conclusion. ТМ is common in infertile men, scrotum ultrasound is indicated to detect it. The suggested algorithm for TM management is aimed towards early testicular cancer detection and successful treatment with fertility potential preservation.
Effect of cryoprecipitate on neoangiogenesis in patients with purulent pyelonephritis
Authors: Chernova Yuliya G. , Nejmark Aleksandr I. , Momot Andrey P.
Published: August 2020

The aim of the study is to investigate the effectiveness of conservative therapy with the inclusion of cryoprecipitate in its composition and its effect on the angiogenesis of renal blood vessels in patients with purulent pyelonephritis.

Materials and methods. The study included 30 patients aged from 20 to 45 years (6 men, 24 women) with acute purulent pyelonephritis. All patients were assessed for markers of angiogenesis in blood plasma: vascular endothelial growth factor (VEGF-A), angiopoietin 1 (Ang1) and angiopoietin 2 (Ang2). The patients were divided into two groups. Patients of group 1 (n = 15) received conservative therapy with the inclusion of cryoprecipitate, patients of group 2 (n = 15) received surgical treatment. The control group consisted of 10 healthy donors aged 2035 years, whose blood angiogenesis markers were determined to obtain reference values.

Results. In the course of preliminary studies, the blood content of angiogenesis markers was determined in 10 healthy donors. The level of VEGF-A in patients of both groups and the level of Ang1 in patients of group 1 at admission to the hospital significantly exceeded the corresponding values in the control group. In group 2 patients, the level of VEGF-A and Ang1 remained elevated during treatment, which indirectly indicated an ongoing inflammatory process. The level of Ang2 in patients of both groups did not change significantly. Conservative treatment of group 1 patients showed high efficiency, which was confirmed by positive dynamics of clinical and laboratory indicators, as well as data from instrumental examination.

Conclusions. The results obtained indicate the effectiveness of conservative therapy with the administration of cryoprecipitate in patients with purulent pyelonephritis, and the effectiveness of such treatment is comparable to the effectiveness of surgical treatment . The use of cryoprecipitate has an endothelioprotective and anti-inflammatory effect on blood vessels, stabilizes the processes of angiogenesis, which contributes to limiting the inflammatory process and its regression.
Professor Georges Marion – outstanding french surgeon and urologist (on the 150th anniversary of the birth)
Authors: Morgoshia Temuri Sh. , Kuzmin Igor V.
Published: August 2020

The article is dedicated to the 150th anniversary of the birth of Professor Georges Marion, an outstanding French surgeon and urologist. The main stages of his clinical and scientific activities are presented. G. Marion is the author of more than 300 scientific papers, including the fundamental guide to urology. He made a great contribution to the development of the surgical field in urology. G. Marion first performed many operations, subsequently named after him, and the hypertrophy of the bladder neck described by him was called Marions disease.
First Russian experience of the stereotactic radiotherapy on the prostate bed
Authors: Novikov Roman V. , Melnik Julia S. , Ponomareva Olga I. , Novikov Sergey N.
Published: August 2020

Purpose. Assess the safety of postoperative radiation therapy on the area of the prostate bed (PB) using extreme dose hypofractionation (5 fractions of 6.67 Gr).

Materials and methods. from April 2019 to March 2020 at the National Medical Center of Oncology named after N.N. Petrov of the Ministry of Health of the Russian Federation in the first 15 patients of the prostate cancer carried out stereotactic radiation therapy (SRT) on the PB. Depending on the clinical situation, adjuvant and salvage SRT were distinguished. Linear electron accelerators with 6 MeV energy are used for treatment. Three factional regimes were evaluated: 5 factions of 6.6 Gr, 5 factions of 6.8 Gr and 5 factions of 7 Gr. The clinical target volume is defined by RTOG (2010).

Results. The median of follow-up was 7.6 (1.3-11.6) months. Of the 15 patients, adjuvant SRT performed three observed, and the remaining 12 patients salvage SRT (4 early, 8 delayed). Acute radiation toxicity was estimated in 12 patients. Early impairment from the lower urinary tract 1 degree was observed in 8 (66.7%) 12 of them. Toxicity of 2 or more degree in the early period was not observed. Clinical signs of early 1st degree toxicity from the rectum were found in five (41.7%) of the bowel of the 12 observed. One patient (8.3%) there was a mixture of blood in the feces, which required a medical correction, which was considered as toxicity of the 2nd degree.

Conclusions. Postoperative SRT of the PB region is a promising modern method of radiation treatment of patients with prostate cancer. The presented methods of adjuvant and salvage SRT are feasible in clinical practice and are characterized by an acceptable level of early radiation toxicity.
Fragmentation of sperm DNA: clinical significance, reasons, methods of evaluation and correction
Authors: Borovets Sergey Yu. , Egorova Viktoria A. , Gzgzian Alexander M. , Al-Shukri Salman Kh.
Published: August 2020

A review of the main causes of male infertility in the aspect of the relationship with the degree of sperm DNA fragmentation is presented. Information is provided on the main methods for assessing sperm DNA fragmentation and its effect on male fertility. The effect of oxidative stress on the integrity of sperm DNA structure, the reparative capabilities of antioxidant therapy, and the effect of varicocele on male fertility are described.
TATA KELOLA PAMERAN BERBASIS PROJECT LEARNING PROGRAM STUDI DESAIN KOMUNIKASI VISUAL UNIVERSITAS DIAN NUSWANTORO
Authors: Khamadi Khamadi , Setiawan Agus
Published: August 2020

Cultivating exhibitions for visual communication design students is to increase the drive to create and enhance the spirit of student appreciation for the work of students to achieve quality and character in the work. The research objective is to know and understand the governance of project learning-based exhibits to improve the quality of learning and build a climate of appreciation for artwork among Udinus visual communication design students. The research method uses qualitative methods which are more emphasized on observation, interviews, documentation. Through the implementation of project learning-based exhibition governance, learning outcomes in improving quality can be achieved.Key Words: Exhibition, Management, Project Learning
KINERJA GURU SENI BUDAYA MENDORONG KEWIRAUSAHAAN MANDIRI DI SEKOLAH MENENGAH KEJURUAN (SMK) SE KOTA MALANG
Authors: Hasyimy Muhammad ‘Afaf , Astuti Yuyun Nur , Jasmine Dewi , Hidajat Robby
Published: August 2020

This article examines the work of art and culture teachers applying entrepreneurship lessons in Vocational High Schools (SMK) throughout Malang, East Java. Entrepreneurship encourages student entrepreneurship from working in the industrial sector and government institutions. Receiving students to move industries that continue to improve The purpose of this study is to examine teacher performance Encouraging students to become entrepreneurs. This research method is descriptive quantitative. Data collection techniques through a questionnaire with Google Form on 11 art and culture teachers who are members of the Subject Teachers Association (MGMP) throughout Malang. Vocational Middle School (SMK) in Malang City is a school that is demanded from the implementation of entrepreneurship so that students have a great opportunity to utilize it as industrial technical personnel. The results showed more male teachers than female teachers, 54.5% male teachers, 45.5% educational background, as motivating students to produce applied art 81.8%. While male teachers are able to encourage students to practice as sellers of school work in markets close to the school. Key Words: Vocational High School, Entrepreneurship, Cultural Arts Teacher, Applied Arts
Clinicopathological evaluation of the lesions of oral cavity, oropharynx, larynx and hypopharynx
Authors: Mittal Himanshu Kumar , Sharma Dev Raj
Published: August 2020

Background: Early detection of malignancy substantially improves the survival in most head and neck cancers. A simpler and reliable screening method is something that is sought after by every clinician. Hence a clinicopathological study was carried out in the local population to study the pattern of various factors associated with the clinically suspicious lesions of the oral cavity, oropharynx, larynx and the hypopharynx. The role of exfoliative cytology was also evaluated.Methods: Our study, comprised of a total of 50 cases clinically suspicious of being either premalignant or malignant lesions of the oral cavity, oropharynx, larynx and the hypopharynx. All the patients were examined thoroughly and diagnosed clinically. Thereafter they were subjected to both exfoliative cytology and histopathology.Results: A malignant laryngeal lesion was the commonest. clinical diagnosis seen in 68% of the cases. On exfoliative cytology, the commonest finding was squamous cell carcinoma, seen in 34 (68%) cases. On histopathological examination, squamous cell carcinoma was found to be the commonest with 39 (78%) cases. The sensitivity and specificity of exfoliative cytology were observed as 84.6% and 90.90% respectively. The methods of diagnosis applied and their results were found to be significantly associated with a p value of 0.0119 which was <0.05.Conclusions: The commonest cause for the suspicious lesions of the oral cavity, oropharynx, larynx and hypopharynx was squamous cell carcinoma seen in 78% of the cases. Rapid assessment tools like exfoliative cytology can aid in early detection of malignant lesions.
A comparison of efficacy between 0.2% of topical glyceryl trinitrate and lateral anal sphincterotomy
Authors: Paul Vivian Anandith , Nagesh Reddy Katpally , Sarath Chandra Alluru
Published: August 2020

Background: Anal fissure is a linear tear in the lining of the anal canal below the dentate line. Among the conservative modalities glyceryl trinitrate (GTN) is emerging as first line of treatment since it breaks the vicious cycle and relaxes the sphincter. Surgery was considered as the first line of treatment if conservative measures such as bulk laxatives, stool softeners and local anaesthetics fail. Aim of this study was to study the aetiology and predisposing factors, age and sex distribution, clinical presentation, position of fissure, complications associated with medical and surgical management and comparison of efficacy of topical GTN (0.2%) and lateral anal sphincterotomy.Methods: The study was based on analysis of 60 patients who were treated for chronic fissure in ano at Malla Reddy Institute of Medical Sciences, Hyderabad from January 2018 to February 2020. Patients were divided into 2 groups. One group was managed by topical application of the ointment and other group was managed by surgery (lateral anal sphincterotomy). Statistical tool (software) used to analyse the data was SPSS 13.0 software.Results: Around 33.33% patients who were managed medically by 0.2% glyceryl trinitrate did not have relief of symptoms. Patients under surgical management had more relief of symptoms (86.6%). Almost all patients treated with glyceryl trinitrate had some form of headache. During the immediate post-operative period 13.3% patients treated with surgery had pain.Conclusions: It can be concluded that open lateral anal sphincterotomy is superior to topical 0.2% GTN with high rate of healing and very low rate of complications.
A IMPORTÂNCIA DOS PROJETOS SOCIAIS NA FORMAÇÃO PROFISSIONAL EM FISIOTERAPIA
Authors: Aguiar Ana Carla de Sousa , Azevedo Giulia Calandrini Pestana de , Bastos Maria Luciana de Barros , Santos Alessandra Aglaíse Melo dos , Lira Soanne Chyara Soares
Published: August 2020

RESUMOO presente estudo objetiva relatar a vivência de acadêmicas de fisioterapia em um projeto social intitulado “Adote Um Sorriso”, na cidade de Belém-PA. As atividades foram desenvolvidas em escolas públicas de ensino infantil. Foram realizadas ações recreativas educativas, ações de anamnese e intervenção terapêutica multiprofissional, palestras informativas aos familiares e doações de brinquedos e livros. A vivência demonstrou que o projeto social de extensão contribuiu de maneira significativa para a formação profissional das acadêmicas, devido proporcionar oportunidades de praticar e aprimorar o conhecimento teórico-prático, melhorar a capacidade de identificar necessidades de intervenção terapêutica, favorecendo o olhar humanizado sobre o indivíduo, proporcionar experiência com equipe multiprofissional e ressaltar a importância do fisioterapeuta na saúde do escolar. Além disso, as atividades desenvolvidas com as crianças e seus responsáveis aumentaram as chances de prevenção de atrasos no desenvolvimento infantil, bem como promoveram diagnóstico e tratamento precoce nos casos de alterações já existentes. Conclui-se que a participação em projetos sociais se apresenta como fator importante para a formação do profissional em fisioterapia.Descritores: Fisioterapia; Formação Profissional; Criança; Humanização; Projeto;
FORMAÇÃO EM SAÚDE MENTAL DE ACADÊMICOS DO CURSO DE MEDICINA
Authors: Bombardelli Luciana Dallazen , Garcia Jr Carlos Alberto Severo , Tesser Giovani , Maeyama Marcos Aurélio
Published: August 2020

A saúde mental tem estado em pauta e está no centro das atenções do século XXI, dada a sua prevalência e importância no bem-estar geral das pessoas. Nesse sentido, a formação médica na área de saúde mental, assume papel importante para contemplar profissionais capazes de lidar com o sofrimento emocional das pessoas. Assim, o objetivo deste trabalho foi de caracterizar a formação em saúde mental do curso de Medicina da Univali, identificando suas potencialidades e fragilidades. O estudo de abordagem qualitativa realizou coleta de dados a partir de entrevistas semiestruturadas com três professores e três alunos do curso. Para análise de dados foi utilizada a técnica de análise de conteúdo temático. A partir da leitura e análise das entrevistas, emergiram quatro categorias relacionadas à formação em saúde mental: organização curricular – com pequena exposição em atividades de saúde mental ao longo do curso e deficiência no processo avaliativo como limitadores no processo formativo; estrutura emocional dos estudantes – fragilidade com a necessidade de suporte emocional e potência pela possibilidade de humanização, necessária para a prática em saúde mental; transferência, contratransferência e projeção – com necessidade de acompanhamento psicológico para o exercício da prática em saúde mental; subjetividade da saúde mental – dificuldade de assimilação pela lógica hegemônica objetiva do modelo tradicional biomédico. Nesse sentido o estudo aponta para a necessidade de uma visão diferente na organização do curso, que transcenda a estrutura curricular focado na disciplina, para o cuidado com o estudante de medicina.
A method for determining the parametric sensitivity of the dynamical systems phase coordinates
Authors: Tushev O.N. , Belyaev A.V.
Published: August 2020

The article presents a rational method for determining sensitivity functions of the first and second orders of phase coordinates to changes in system parameters and external effects. With this approach it is not necessary to integrate intricate chain- coupled differential equations with respect to sensitivity functions of various orders. A vector of additional variables (invariants) of the same dimension is introduced as the vector of phase coordinates. To find it, a conjugate linear inhomogeneous differential equation is obtained, which must be integrated in the inverse time. The sensitivity functions of any order can be calculated independently from each other using this vector. No assumptions reducing the accuracy of the result or restricting the capabilities of the method are made. The linearity of the equation with respect to invariants allows solving the problem in the more convenient form. Using the recurrence relation, the sensitivity functions are calculated sequentially in time from the initial point. The solution of the equation is expressed through a fundamental matrix which is computationally treated as a multiplicative integral. The results are illustrated by the example.