bluuebunny/crossref_metadata_2025 huggingface dataset:
GAMBARAN KEJADIAN IBU HIPERTENSI DALAM KEHAMILAN DENGAN COVID-19 DI RSUD ULIN BANJARMASIN PERIODE MEI 2020-JUNI 2021
Authors: Arumningtyas Rahayu , Armanza Ferry , Wasilah Siti , Yuseran Hariadi , Rosida Lena
Published: March 2023

Hypertension in pregnancy is one of the most common causes of maternal death in Indonesia as well as in other developed countries such as the United States. The cause of preeclampsia is currently uncertain, but there are several risk factors that can increase the occurrence of preeclampsia. Coronavirus disease 19 (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2). Pregnant women and hypertension are factors that can increase the risk of COVID-19. If not treated properly, hypertension in pregnancy can cause maternal and fetal morbidity and mortality. The purpose of this study was to describe the incidence of maternal hypertension in pregnancy with COVID-19 based on age, parity, gravida, history of preeclampsia, and education at Ulin Hospital Banjarmasin for the period May 2020-June 2021. This research method was descriptive with data collection through medical records. patient. The sampling technique used is total sampling. The subjects of this study amounted to 88 patients. This study shows preeclampsia is the type of hypertension in pregnancy with COVID-19 being the most common, which was 57 patients (64.7%). Most of the patients were in the age range of 20-35 years, as many as 52 patients (59.3%). Based on parity, most of the cases occurred in mothers with multilipara as many as 39 patients (44.3 %). Gravida was found mostly in mothers with multigravida as many as 63 patients (71.6%). Based on a history of preeclampsia, patients who did not have a history of preeclampsia were found to be more than patients who had a history of preeclampsia, namely as many as 52 patients (59.1%) and the majority of patients' education at the high school level, which was 29 patients (32.9%).
EFEKTIVITAS TERAPI INFARED DAN LOW LEVEL LASER THERAPHY TERHADAP PASIEN NYERI PUNGGUNG BAWAH
Authors: Mahardika Sheila Putri , Siddik Muhammad , Santoyo Didik Dwi , Dwiputranto Bambang , Pambudi Pagan
Published: March 2023

Low back pain (LBP) is the most common complaint of low back pain. One of the treatments that can be done is non-pharmacological therapy, namely therapy IR and low level laser therapy (LLLT). Both have similarities in electromagnetic radiation hyperthermia, and serve to reduce pain severity, reduce disability in low back pain patients. The aim of this literature review is to compare the effectiveness of IR and LLLT in reducing pain in low back pain patients. The writing was done by analyzing the literature from several electronic medical journal databases, namely: PubMed-NCBI, ProQuest, Science Direct and Google Scholar. The criteria for inclusion of articles are articles in English and Indonesian in research published in 2011–2021. There are 5 articles used in this literature review. The results of the review found that IR and LLLT were equally effective in reducing pain in low back pain patients. Three out of five IR articles showed more effective results in reducing low back pain. Two of the five articles of LLLT showed more effective results in reducing low back pain, that IR and LLLT have the same effectiveness in reducing low back pain
HUBUNGAN NILAI MINI NUTRITIONAL ASSESSMENT (MNA) DENGAN LAMA RAWAT INAP
Authors: Fatimah Siti Hafizhah , Cahyawati Wiwit Agung Sri Nur , Panghiyangani Roselina
Published: March 2023

Mini Nutritional Assessment (MNA) is an instrument for assessing and screening specific nutritional in the elderly. Elderly are vulnerable to malnutrition because of physiological and functional changes that contribute to increase length of stay. The purpose of this study was to determine the correlation between Mini Nutritional Assessment value with length of stay of elderly patients at RSUD Ulin Banjarmasin. This research is analytic observational with cross-sectional method. A sample of 32 elderly patients was analysis used Spearman correlation test. The  median MNA value was 20.00 points and the median length of stay was 8.00 days. The results of the correlation test showed that the value of p = 0.002 and value of r = -0.532 which means there is a significant correlation and a strong correlation with a negative direction. It can be concluded that there is a correlation between the Mini Nutritional Assessment (MNA) value with length of stay of elderly patients in internal medicine ward at RSUD Ulin Banjarmasin.
HUBUNGAN INFILTRASI LIMFOSIT PADA PROSTAT DENGAN RETENSI URINE PADA BENIGN PROSTATIC HYPERPLASIA DI RSUD ULIN BANJARMASIN
Authors: Ramadhan Muhammad Abianovan , Sutapa Hendra , Oktaviyanti Ika Kustiyah , Rahman Eka Yudha , Yuliana Ida
Published: March 2023

Benign prostatic hyperplasia (BPH) is a common condition in elderly men. BPH may cause lower urinary tract symptoms (LUTS) and urinary retention. Chronic inflammation is a common founding in histological examination of BPH and related to a higher risk of urinary retention. The purpose of this study is to analyze the association between lymphocyte infiltration in prostate and urinary retention in BPH in Ulin General Hospital Banjarmasin. This is an analytic observational study with cross sectional approach. There are 78 samples, collected by purposive sampling method. There are 47 (60,26%) patients diagnosed with urinary retention, while 31 (39,74%) others are diagnosed with LUTS. Lymphocyte infiltration is found in 68 (87,18%) specimens, consist of 20 (25,64%) specimens of BPH with mild inflammation, 34 (43,59%) specimens of BPH with moderate inflammation, and 14 (17,95%) specimens of BPH with severe inflammation. There is no lymphocyte infiltration found in 10 (12,82%) specimens. The result of the analysis is P = 0,320. The conclusion of this study is that there is no significant association between lymphocyte infiltration in prostate and urinary retention in BPH in Ulin General Hospital Banjarmasin
Garcinia exigua (Clusiaceae), a new record for Thailand
Authors:   Department of Botany, Faculty of Science, Kasetsart University, Chatuchak, Bangkok 10900, Thailand, Ngernsaengsaruay Chatchai , Boonthasak Weereesa ,   Department of Botany, Faculty of Science, Kasetsart University, Chatuchak, Bangkok, 10900 Thailand, Meeprom Nattanon ,   School of Biological Sciences, University of Reading, Reading, RG6 6AS United Kingdom, Tetsana Naiyana ,   Forest Herbarium, Department of National Parks, Wildlife and Plant Conservation, Bangkok 10900, Thailand, Suddee Somran ,   Forest Herbarium, Department of National Parks, Wildlife and Plant Conservation, Bangkok 10900, Thailand
Published: March 2023

Garcinia exigua (Clusiaceae), previously known from Borneo [Malaysia (Sarawak) and Brunei], is reported as a new record from dry evergreen forest on limestone hill in Krabi Province, Peninsular Thailand. A detailed morphological description, illustrations and a distribution map of the species are provided, along with information on distribution, specimens examined, habitat, conservation status, phenology, etymology and vernacular name.
1D CNN model for ECG diagnosis based on several classifiers
Authors: Bassiouni Mahmoud , Hegazy Islam , Rizk Nouhad , El-Dahshan El-Sayed , Salem Abdelbadeeh
Published: March 2023

One of the main reasons for human death is diseases caused by the heart. Detecting heart diseases in the early stage can stop heart failure or any damage related to the heart muscle. One of the main signals that can be beneficial in the diagnosis of diseases of the heart is the electrocardiogram (ECG). This paper concentrates on the diagnosis of four types of ECG records such as myocardial infarction (MYC), normal (N), variances in the ST-segment (ST), and supraventricular arrhythmia (SV). The methodology captures the data from six main datasets, and then the ECG records are filtered using a pre-processing chain. Afterward, a proposed 1D CNN model is applied to extract features from the ECG records. Then, two different classifiers are applied to test the extracted features’ performance and obtain a robust diagnosis accuracy. The two classifiers are the softmax and random forest (RF) classifiers. An experiment is applied to diagnose the four types of ECG records. Finally, the highest performance was achieved using the RF classifier, reaching an accuracy of 98.3%. The comparison with other related works showed that the proposed methodology could be applied as a medical application for the early detection of heart diseases.
Comparative analysis of modified semi-supervised learning algorithms on a small amount of labeled data
Authors: Lyubchyk Leonid , Yamkovyi Klym
Published: March 2023

The paper is devoted to improving semi-supervised clustering methods and comparing their accuracy and robustness. The proposed approach is based on expanding a clustering algorithm for using an available set of labels by replacing the distance function. Using the distance function considers not only spatial data but also available labels. Moreover, the proposed distance function could be adopted for working with ordinal variables as labels. An extended approach is also considered, based on a combination of unsupervised k-medoids methods, modified for using only labeled data during the medoids calculation step, supervised method of k nearest neighbor, and unsupervised k-means. The learning algorithm uses information about the nearest points and classes’ centers of mass. The results demonstrate that even a small amount of labeled data allows us to use semi-supervised learning, and proposed modifications improve accuracy and algorithm performance, which was found during experiments.
Methodological aspects of operative control system intellectualization for dynamic objects
Authors: Melnykov Serhii , Malezhik Petro , Gasanov Aydin , Bidyuk Petro
Published: March 2023

The problems of intelligent control system organization are considered: determining the number of intellectualization levels, the sequence of actions required for analysis of the control process, adding to the control system new elements providing for enhancement degree of its intellectualization, special features of its structural organization, estimating the possibilities of intellectualization, providing examples of practical intellectualization. The primary purpose of the study is to determine the purposeful organization of intelligent control systems as well as the necessity and usefulness of systemic consideration that takes into consideration the following: requirements of the problem statement, characteristics of the environment, means for acquiring and processing necessary information, working control mechanisms, functional characteristics and experience of user-operator. As a result of the analysis performed, characteristic levels of the intellectual development of a system were determined, the stages of performing intellectualization of a control system were proposed, and the effectiveness of proposed solutions for practical problems was shown.
Typical and generalized transitions to deterministic chaos for atypical attractors of non-ideal dynamic systems
Authors: Shvets Aleksandr
Published: March 2023

Some applied nonlinear, non-ideal dynamic systems of the fifth order, which are used to describe the oscillations of spherical pendulums and in hydrodynamics, are considered. Maximal attractors, both regular and chaotic, of such systems are constructed. Various bifurcations of maximal attractors are discussed. The transition to deterministic chaos is established for maximal attractors in typical Feigenbaum and Manneville–Pomeau scenarios. The implementation of the generalized alternation scenario for chaotic maximum attractors of such systems is investigated. A sign of the implementation of the scenario of generalized alternation has been revealed.
HOTEL MANAGEMENT EDUCATION WITH THE CREATIVE DRAMA METHOD: A FOLLOW-UP STUDY
Authors: ÖZOĞUL BALYALI Tuğçe , GÜNAY AKTAŞ Semra
Published: March 2023

Purpose - The aim of this research is to determine if the creative drama method, which has been shown to be effective in hotel management education, is also effective when applied to another student group. Design - A quasi-experimental design was used in the hotel management course taught using the creative drama method and direct instruction. Methodology - The research onion model and a quantitative method were used. A pre-test, a post-test, retention tests, and an attitude scale towards the course were applied to both the control and experimental groups. The time horizon of the study is cross-sectional, as the study was carried out over a specific time period. In the research, data were collected with achievement tests with difference analyses being made. Approach - Based on the idea that information regarding the effectiveness of this method can only be accessed with data obtained by experimentation, a positivist approach is adopted. Findings - The creative drama method is effective in terms of academic success, retention of knowledge, and development of positive attitudes toward the course, even when applied to a different group of students. Originality of the research - The efficiency of the creative drama method in tourism education is not limited to the study group and is not random.
THE ESSENCE OF DISASTER EDUCATION AT THE JUNIOR HIGH SCHOOLS IN LANDSLIDE DISASTER PRONE-AREA, TAWANGMANGU, INDONESIA
Authors: Indyastuti Tri , Alfanisa Safira , Ningrum Mifta Widya , Agung Rehan Permana , Kurniansyah Alif Akbar , WIbowo Yunus Aris
Published: March 2023

Disaster education is an effort that is expected to increase preparedness and reduce the risk posed by a natural disaster. One area that has a high risk of landslides is the Karanganyar Regency. This study aims to analyze the urgency of disaster education and the role of Junior High schools in supporting disaster education in landslide-prone areas, Tawangmangu Subdistrict. The approach used in this study is a quantitative approach using primary data obtained through questionnaires and interviews. The sampling technique in this study used a purposive sampling technique where the research samples were Social Science subject teachers at State Junior High School 01 of Tawangmangu, Junior High School of Amal Mulya Tawangmangu, and Junior High School of Penda Tawangmangu. The analytical technique used was descriptive statistical analysis. Based on the results, it can be concluded that schools were aware of the essence of disaster education. The Junior High Schools in Tawangmangu Subdistrict supports the urgency of disaster education, by realizing its role through several activities in schools that can increase the preparedness, capacity, and knowledge of students against potential hazards around their houses. With the existence of disaster education in schools, it is expected to be able to increase the capacity of students to reduce the risk posed by a landslide disaster. 
GEOGRAPHICAL INFORMATION SYSTEM BASED COVID-19 VULNERABILITY MAPPING IN PONTIANAK REGENCY WEST KALIMANTAN
Authors: Purwanto Ajun , Nugraha Yoga Prasetya Adi
Published: March 2023

2020 was the start of the toughest year for the world community in general, especially Indonesia in the health sector. The outbreak of the Covid-19 case in various regions requires clear and accurate information in efforts to deal with this pandemic. This study aims to spatially map the vulnerability of COVID-19 based on Geographic Information Systems (GIS). The method d used is a weighted overlay. The data used are population (P), population density (PD), elderly (EP), school students (SS), and hospital beds (HB). The analysis s used is a spatial analysis using ArcGIS 10.8. The results of the study show that North Pontianak District has a very high vulnerability to COVID-19. West Pontianak District and Pontianak City have high vulnerability. South and East Pontianak sub-districts have moderate vulnerability. For Pontianak Tenggara District, the level of vulnerability to COVID-19 is very low. The vulnerability to COVID is very low in Southeast Pontianak District because it has the smallest population, low density, few elderly people, few school-age children, and lots of hospital beds. An information system is an effective tool in conveying information on the spatial distribution of the level of vulnerability of Covid-19 in an area, so that steps and handling policies can be  taken according to existing priorities.
SPATIAL DISTRIBUTION OF HOTSPOTS USING S-NPP VIIRS FOR EARLY DETECTION OF POTENTIAL FIRE
Authors: Kumalawati Rosalina , Dewi Avela , Yuliarti Astinana , Anggraini Rizky Nurita , Murliawan Karnanto Hendra
Published: March 2023

Fire is a disaster and its frequency is increasing every year. Seeing this, it is very important to know the spatial distribution of hotspots to determine the potential for fires in each area. Based on this, it is necessary to conduct research with the title "Spatial Distribution of Hotspots Using S-NPP VIIRS for Early Detection of Potential Fires". This research includes the type of descriptive research. The population in the study were all hotspots in Banjar Regency, South Kalimantan Province. Hotspots were taken from the results of the S-NPP VIIRS satellite imagery recording from 2012-2021. The number of samples is equal to the number of populations. The data analysis technique uses nearest neighbor analysis and descriptive analysis which is processed using Arc GIS software. The research results show that fires occur during the dry season, namely in July, August, September and October. Spatial distribution of hotspots from the results of S-NPP VIIRS satellite imagery based on the accuracy of the most confidence level in July, August, September and October. If the spatial distribution of hotspots is known, it can be used as an early detection effort. Early detection is carried out as an effort to prevent and control fires with a greater negative impact. In addition, with the existence of an early warning system, the community is better prepared to deal with fires so that the negative impacts that may arise due to fires can be minimized, including loss of life and property. 
STUDI KARAKTERISTIK PROSES PIROLISIS CEPAT RDF-5 BEBRBAHAN DASAR LIMBAH AREN DAN KOPI DENGAN PENGIKAT LIMBAH PLASTIK TERHADAP KUANTITAS BIO-OIL
Authors: Riswanda Muhammad
Published: March 2023

Currently, the Indonesian people are faced with various problems in terms of waste management, both organic and inorganic waste. Some of the wastes that can be used are palm waste, coffee grounds and HDPE plastic waste which can be used as alternative fuels, one of which is through the pyrolysis process. Pyrolysis is a process of chemical decomposition of a material thermally in the absence of oxygen. This pyrolysis process converts RDF-5 biomass into a liquid smoke product in the form of bio-oil. This study aims to determine the quantity of pyrolysis oil through the best variation of the composition ratio used. In this study used composition ratio variables, namely 50%:30%:20%, 40%:40%:20%, and 30%:50%:20%. The results of this study obtained the best quantity from a mixture ratio of 50% palm waste, 30% coffee grounds and 20% HDPE plastic to produce 200 ml. The composition ratio affects the quantity of pyrolysis oil results. RDF-5 from palm waste and coffee grounds with HDPE plastic waste binder produces a quantity that tends to decrease as the composition ratio of palm waste waste decreases.
INVESTIGASI EKSPERIMENTAL PEMANAS AIR TENAGA SURYA SISTEM TRICKLE BERBAHAN GALVALUM-FIBER LAJU ALIRAN 2 LPM
Authors: Salsala Robby Nur , Pambudi Nugroho Agung , Wardani Nyenyep Sri
Published: March 2023

This study aims to analyze the performance of a solar water heater made of galvalum-fiber with a trickle system using a flow rate of 2 lpm. The research was conducted by experimental method. This research was conducted by flowing water through a solar water heater and collecting data at 08.00-15.00 with 3 repetitions to get accurate results. Data collection was carried out by recording the temperature at the inlet, outlet, collector, cover, environment, solar radiation intensity, and wind speed. The data obtained were analyzed to determine collector efficiency, fluid efficiency and total efficiency. Based on research results, this solar water heater is capable of producing water temperatures of up to 36.8°C with temperature changes of up to 6.6°C. This solar water heater is capable of generating collector efficiency of up to 51%, and a total efficiency of 34%.
Geometric Entropy of plant leaves: A measure of morphological complexity
Authors: M Vishnu , Rajan Sajeev C , R Jaishanker
Published: March 2023

Shape is an objective characteristic of an object. A boundary separates a physical object from its surroundings. It defines the shape and regulates energy flux into and from an object. Visual perception of a definite shape (geometry) of physical objects is an abstraction. While the perceived geometry at an object's sharp interface (macro) creates a Euclidian illusion of actual shape, the notion of diffuse interfaces (micro) allows an understanding of the realistic form of objects. Here we formulate a dimensionless geometric entropy of plant leaves (SL) by a 2-D description of a phase-field function. We applied this method to 109 tropical plant leaf images. SL was estimated from the leaf perimeter (P) and leaf area (A). It correlates positively with a fractal dimensional measure of leaf complexity, viz., segmental fractal complexity. Leaves with a higher P: A ratio has higher SL and possesses complex morphology. The univariate cluster analysis of SL reveals the taxonomic relationship among the leaf shapes at the generic level. An increase in SL of plant leaves could be an evolutionary strategy. The results of morphological complexity presented in this paper will trigger discussion on the causal links between leaf adaptive stability/efficiency and complexity. We present SL as a derived plant trait to describe plant leaf complexity and adaptive stability. Integrating SL into other leaf physiological measures will help understand energy dynamics and information flow in ecological systems.
Occurrence of Spiroplasma citri in Algerian Citrus Orchards
Authors: Benazzouz Kinza , Belkahla Hadjira , Dubrana Marie-Pierre , Lehad Arezki
Published: March 2023

Algeria is a country known for a varietal variety of Citrusfruits, which are susceptible to serious pathologies such as stubborn disease (Spiroplasma citri), causing significant economic losses. The current study was conducted in order to investigate the possible existence of different Spiroplasma citri strains in Algeria. Samples of fresh leaves and orange-tree fruits (Citrus sinensis L.) with stubborn symptoms were detected in Boumerdes and Blida province. Identification of the causative agent (Spiroplasma citri) was ensured by ELISA and PCR techniques. DNA extracted from symptomatic samples were used as a template for amplification of products of 675 bp using primer pairs Spiralin (Sc1 / Sc1-) and (SpiF / SpiR) by PCR. Furthermore, the spiralin gene was cloned and sequenced. About 18,23% of the samples, showing clear-cut stubborn symptoms, were ELISA-positive. Molecular characterization by sequence analysis has identified two Algerian isolates with 99% homology between them. Spiroplasma citri Isolate 12 (OQ078580) and Spiroplasma citri isolate 14 (OQ068387). Phylogenetic tree showed that the Algerian Spiroplasma citriisolates are more closely related to the Egypt, Israel, than those isolated from Iran and Corse.
Simulation of computer image recognition technology based on image feature extraction
Authors: Ying Weiqiang , Zhang Lingyan , Luo Shijian , Yao Cheng , Ying Fangtian
Published: March 2023

Humans have the ability to quickly identify their own environment, understand, judge and analyze it, which is one of the important reasons why human beings can survive in nature for a long time and gradually develop it into a prosperous society today. The key to human's ability to perceive and understand the environment lies in the ability to accurately find and identify objects, understand and describe visual scenes, and even express emotions on this basis. And if computers can realize automatic and accurate image recognition, and even understand the semantics of images correctly, it will surely improve and facilitate human life. One of the research hotspots in this field is the human visual system, so one of the important research directions of new science and technology is image recognition. In this context, this paper completes the design and improvement of the computer image recognition system. The core technology of the system is to improve the image algorithm, which can complete the training, testing and classification of target images. The experimental data is available. Choosing this algorithm to improve the learning and training of the data generated by the original image processing is more effective than directly training the original image.
Assessing cognitive mental workloads of assembly workers during multi-task switching
Authors: Ren Bin , Zhou Qinyu , Chen Jiayu
Published: March 2023

Complex assembly tasks with multiple manual operations and steps often require rapid judgment and action under time pressure and cause most human-related errors. The task switching and action transitions are major sources of these errors. This study intends to implement an electroencephalography (EEG) approach to quantitatively evaluate the mental workload during task switching and transition. The time-frequency and spectrum analysis were utilized to compute and reflect the task demand between the intervals of individual tasks. This study developed an experiment to validate the proposed assessment approach and benchmark the results with the National Aeronautics and Space Administration task load index (NASA-TLX) subjective evaluation scale analysis. The results show that the average value of the power spectral densities (PSDs) of the gamma band signal of the AF4 channel and the beta band signal of Channel F3 show distinctive signal patterns among task stages and intervals. During the interval between the idling stage and the part selection stage, the peak of the PSD envelope increased from 18Hz to 27Hz, suggesting advanced cognition increases the mental workload of the interval between different tasks. Therefore, the task switching period cannot be regarded as rest and need to be optimized with better task organization.
Decreased atmospheric deposition of heavy metals shown by long-term monitoring using the moss Pleurozium schreberi
Authors: Tabors Guntis , Brūmelis Guntis , Nikodemus Oļģerts , Dobkeviča Linda , Viligurs Konstantīns
Published: March 2023

In Europe, economical restructuring and technological progress has been aimed at reducing pollution emmissions at local, regional and global scales, which has been monitored using standard methods. Among the many methods used to determine deposition of heavy metals, in Europe moss has been used to monitor atmospheric pollution for more than 30 years on a 5-year cycle. Thus, this simple method can be used to assess improvement to the environment after massive economic change. Using PCA analysis, this study examines the long-term trends of heavy metal concentrations (Cr, Cu, Ni, Pb, V, Zn) in Latvia. There has been an decline in heavy metal concentrations in Latvia related to the closure of large industries after the the collapse of the Soviet Union and due to change in fossil fuels in the energy sector from petroleum to natural gas, but past effect from some sourses is still evident. Increased quality of automobile fuel led to a decrease of lead concentration, and conversion of fuel source in the energy sector from oil to natural gas caused a decline of V and Ni concentration.
Association between coffee and caffeine intake and functional dyspepsia
Authors: Koochakpoor Glareh , Salari-Moghaddam Asma , Keshteli Ammar Hassanzadeh , Esmaillzadeh Ahmad , Adibi Peyman
Published: March 2023

Objective: No previous study has examined the association between coffee and caffeine intake and odds of functional dyspepsia (FD). The aim of this study was to investigate the association between coffee and caffeine intake and odds of FD and its components in a large sample of Iranian adults.
Design: In this cross-sectional study, a validated food frequency questionnaire (DS-FFQ) was used to assess dietary intakes. A validated modified Persian version of the Rome III questionnaire was used for assessment of FD. Logistic regression was applied to compute odds ratios for FD and its components considering a wide range of covariates.
Setting: Isfahan, Iran
Participants: 3362 Iranian adults aged 18-55 years
Results: Mean age of study population was 36.2±7.8 of them 58.3% were females. The prevalence of FD among study participants was 14.5%. The prevalence of post-prandial fullness, early satiation, and epigastric pain was 7.6, 5.8, and 7.6%, respectively. After controlling for potential confounders, no significant association was observed between coffee (OR:1.27; 0.86-1.87), and caffeine (OR:1.00; 0.99-1.02) consumption and odds of FD. In addition, coffee and caffeine consumption was not significantly associated with odds of FD symptoms such as early satiation, post-prandial fullness, and epigastric pain. This was also the case when the analysis was done stratified by gender and BMI status.
Conclusion: We found no significant association between coffee and caffeine consumption with odds of FD and its symptoms. Further research in other populations with high coffee consumption is needed.
Cytokine CCL7-mediated activation of mesenchymal stem cells to promote urinary continence via periurethral fibroblasts mechanism
Authors: Ibrohimov Alisherjon , Cai Hanni , Jiang Minghui , Wang Yuxiao , Liu Jiahui , Wang Yufeng , Zhang Pengfei , Li Haiyan , Jiang Hai-Hong
Published: March 2023

Stress urine incontinence (SUI) is common in middle-aged and older people, and there are no effective treatments. In our investigation, MSC secretion activated periurethral fibroblasts. MSC secretion concentrate improves stress urinary incontinence in animal models. Our work indicated that CCL7 recruits activated MSC cells. This study compared the omics expression of associated secretions after CCL7 was added to activate mesenchymal stem cells and the molecular regulatory mechanisms involved.
Periurethral fibroblasts were immortalised from patients with urine incontinence and anterior pelvic prolapse. Proteomic analysis was used to examine the composition of conditioned media obtained from bone marrow stromal cells and to study the link between fibroblast proliferation and migration and, eventually, signal route incurred changes. We identified the most plausible PI3k/AKT signal transduction route for activating periurethral fibroblasts generated by CCL7 and MSC secretions.
CCL7+MSC-CM promoted collagen production, proliferation, and migration of periurethral fibroblasts better than MSC-CM. PI3k/AKT-related pathways linked with increased fibroblast proliferation and migration were activated.
After CCL7 intervention, MSC-CM activated periurethral fibroblasts through PI3k/AKT. EFNA1 may play a critical role in the proliferation of periurethral fibroblasts, contributing to urinary continence and architecture.
Genome-wide identification of trihelix transcription factors in the apple genome in silico
Authors: Kuzmitskaya Polina , Koroleva Ekaterina , Urbanovich Oksana
Published: March 2023

Trihelix transcription factors are involved in the growth and development of plants, as well as various stress responses. In this work, we have identified 37 genes of the trihelix family in the apple genome (MdTH). They were located on 13 chromosomes. Phylogenetic analysis showed that apple trihelix transcription factors belong to one of six subfamilies (GT-1, GT-2, SH4, SIP1, GTγ and GTδ). Genes from different groups have differences in the gene structure and conserved functional domains. Analysis of the promoter regions of apple trihelix transcription factors showed that their expression may be regulated by light, phytohormones, stress factors such as anaerobic stress, drought, low temperature, a pathogen attack, an injury, etc. In our work, we have demonstrated that drought, salinity, as well as high and low temperatures, affect the expression of genes of the apple trihelix family. Among the genes under study, the greatest increase in the expression level under soil salinity was observed in MdTH4 and MdTH24 genes. The MdTH4 gene also showed the greatest increase in the relative expression level during drought. With decreasing temperature, the greatest change in the expression level was observed in MdTH30. The same gene was among the three genes whose expression level was significantly decreasing when exposed to drought. With an increase in temperature, the expression level of three genes demonstrated the greatest increase: MdTH8, MdTH20, and MdTH36.
Taxonomy, phylogeny and evolution of freshwater Hypocreomycetidae (Sordariomycetes)
Authors: Bao Dan-Feng , Hyde Kevin D. , Maharachchikumbura Sajeewa S. N. , Perera Rekhani H. , Thiyagaraja Vinodhini , HONGSANAN Sinang , Wanasinghe Dhanushka N. , Shen Hong-Wei , Tian Xingguo , Yang Li-Quan , Nalumpang Sarunya , Luo Zong-Long
Published: March 2023

Hypocreomycetidae is a highly diverse group with species from various habitats. This subclass has been reported as pathogenic, endophytic, parasitic, saprobic, fungicolous, lichenicolous, algicolous, coprophilous and insect fungi from aquatic and terrestrial habitats. In this study, we focused on freshwater fungi of Hypocreomycetidae which resulted 41 fresh collections from China and Thailand. Based on morphological and phylogenetic analyses, we identified 26 species that belong to two orders (Hypocreales and Microascales) and six families (Bionectriaceae, Halosphaeriaceae, Microascaceae, Nectriaceae, Sarocladiaceae and Stachybotryaceae). Ten new species and 13 new habitats and geographic records are introduced. Mariannaea superimposita, Stachybotrys chartarum and S. chlorohalonatus are recollected from freshwater habitats in China. Based on phylogenetic analysis of combined LSU, ITS, SSU, rpb2 and tef1-α sequences data, Emericellopsis is transferred to Hypocreales genera incertae sedis; Pseudoacremonium is transferred to Bionectriaceae; Sedecimiella is placed in Nectriaceae; Nautosphaeria and Tubakiella are excluded from Halosphaeriaceae and placed in Microascales genera incertae sedis; and Faurelina is excluded from Hypocreomycetidae. Varicosporella is placed under Atractium as a synonym of Atractium instead of Varicosporella. In addition, phylogenetic analysis and divergence time estimates showed that Ascocodina, Campylospora, Cornuvesica and Xenodactylariaceae form distinct lineages in Hypocreomycetidae and they evolved in the family/order time frame. Hence, a new order (Xenodactylariales) and three new families (Ascocodinaceae, Campylosporaceae, and Cornuvesicaceae) are introduced based on phylogenetic analysis, divergence time estimations and morphological characters. Ancestral character state analysis is performed for different habitats of Hypocreomycetidae including freshwater, marine and terrestrial taxa. The result indicates that marine and freshwater fungi evolved independently from terrestrial ancestors. The results further support those early diverging clades of this subclass, mostly comprising terrestrial taxa and freshwater and marine taxa have been secondarily derived, while the crown clade (Nectriaceae) is represented in all three habitats. The evolution of various morphological adaptations towards their habitual changes are also been discussed.
The impact of personality traits on the positive mental health of Canadian adults during the COVID-19 pandemic: A Replication and Extension Study
Authors: Shokrkon Anahita , Nicoladis Elena
Published: March 2023

The COVID-19 epidemic was first reported in 2019 and rapidly spread across the globe. Many studies have shown that the COVID-19 pandemic adversely affected mental health. Individual differences such as personality could influence people’s responses to the pandemic. For example, the results of a previous study by Shokrkon and Nicoladis (2021) showed that the personality trait of Extroversion positively and Neuroticism negatively contributed to the mental health of Canadians. The goal of our study was to replicate this study using the same tasks and a similar population and extend it by including all 5 personality traits in our analysis and also controlling for the variable of Response to COVID-19 Stress (in addition to demographic variables). Our results were similar to Shokrkon and Nicoladis (2021) and we also found that Extroversion positively and Neuroticism negatively are associated to the mental health of Canadians. We also found that Agreeableness, Openness to Experience, and Conscientiousness are positively and significantly related to the mental health of Canadians. Our results could provide a guide for the screening of people more at risk for mental health issues based on personality traits.
Block-based teaching method based on cybernetics: A trial with 115 Chinese undergraduate medical students
Authors: Liu Zhi-Ping , Liu Si-Han , Dai Xin , Chen Jie , Guo Qing-Feng , Zhang Da-Xin
Published: March 2023

Background: The number of medical undergraduate students in Chinese college classes ranges from dozens to over 100. As a result, the interaction between teacher and students is difficult to conduct. Student attendance and participation need to be improved.
Methods: Two classes of fourth-year undergraduate medical students, with each class comprising 115 students, participated in the study. One class was the trial group taught by the block-based teaching method based on cybernetics. This study was conducted with three of the courses in the Introduction to Oncology. The course of the trial group included several blocks. Each block had a test paper, which was answered immediately by students in class using the Internet. The teacher received feedback from the students when the correct rate of response was less than 90%. The teacher adjusted the teaching in the following blocks according to feedback information. The other class was the control group being taught with the traditional lecture-based teaching method.
Results: The average number of attendees in the trial group was 104/115 (90.43%) and that in the control group was 83/115 (72.17%) (p=0.0003). The teacher adjusted teaching three times in the radiotherapy course due to the difficulty of knowledge. Feedback and adjustment of the upper body of chemotherapy was once and the lower body of chemotherapy was once due to the students’ attitudes to the class. The average total score of the trial group was 86.06 ± 7.46 and that of the control group was 80.38 ± 6.97 (p=0.041). Questionnaire I showed that the trial group students’ attendance and participation was better than the control group. Questionnaire II showed that the block-based teaching method based on cybernetics was approved by the students.
Conclusions: The block-based teaching method based on cybernetics had good effects in medical classes with large number of Chinese undergraduates.
Staphylococcus aureus contamination of animal-derived foods in Nigeria: A systematic review, 2002 - 2022
Authors: Odetokun Ismail Ayoade , Adetona Mutiat Adenike , Ade-Yusuf Rodhiat Oyinlola , Adewoye Adeola Oluwafunmibi , Ahmed Aliyu Nuhu , Ghali-Mohammed Ibrahim , Al-Mustapha Ahmed Ibrahim , Fetsch Alexandra
Published: March 2023

Background: Staphylococcus aureus (S. aureus) is a bacterium of public health importance. The zoonotic spread of this pathogen through animal-derived foods has been reported. This systematic literature review investigates the prevalence, distribution, antimicrobial resistance (AMR) profiles, and molecular characteristics of S. aureus in the food chain in Nigeria.
Methods: A systematic search of online databases (Pub Med, Google Scholar, and Web of Science) for published articles from January 2002 to January 2022 was performed using the Prisma guideline.
Results: Fifty articles were included from an initial 511 extracted documents. These papers included research carried out in 22 states across Nigeria. S. aureus detection in most studies was above the satisfactory level for foods (≥ 104CFU/g). The prevalence of S. aureus ranged from 1.3% in raw cow meat to 72.5% in fresh poultry meat. Most S. aureus isolates demonstrated multiple drug resistance patterns, especially being resistant to beta-lactams. There is a lack of information on the molecular typing of the S. aureus isolates. The different spa types of S. aureus isolated were t091, t314, t1476, and t4690, categorized into Multi-Locus-Sequence Types ST8, ST121, ST152, and ST789. Virulence genes detected include pvl, sea, see, spa, coa, edin, tsst, and hly. Certain AMR-encoding genes such as mecA, blaZ, fos, tet, and dfsr were detected. Factors contributing to the presence of S. aureus were reported as poor processing, poor sanitary conditions of the food processing units, inadequate storage units, and poor handling.
Conclusion: We showed that S. aureus is a major food contaminant in Nigeria despite the lack of information on the molecular typing of strains from animal-derived food sources. There is a need to control S. aureus by targeting specific entry points based on the findings on risk factors and drivers of food contamination.
Inhibitions from syngas impurities: impact of common tar components on a consortium adapted for syngas biomethanation
Authors: Figueras Julie , Benbelkacem Hassen , Dumas Claire , Buffiere Pierre
Published: March 2023

In a circular economy approach, syngas biomethanation is a promising technology for waste to energy conversion. However, syngas can contain impurities, notably tar, that can limit the processes upgrading syngas downstream gasification. The effect of tar on syngas biomethanation is unknown. Therefore, for the first time, common tar components were tested on a consortium adapted for syngas biomethanation to assess the resistance of the microorganisms. Four light tar components (benzene, toluene, styrene and phenol) commonly found in syngas were selected and tested at different concentrations in batch tests. Adding pollutant up to inhibitory concentrations affected both the lag phase and the rates of the bioreactions. Hydrogenotrophic methanogens were found to be more sensitive than carboxydotrophs. Amongst the four tested pollutants, phenol appears to be the most problematic, due not only to its high inhibitory effect but also to its high solubility, allowing phenol in the syngas to reach high inhibitory concentrations. This study paves the way for further research on the resistance of syngas biomethanation to impurities contained in the syngas.
Elucidation of interfacial microstructure inhomogeneity and crack defects of laser fusion brazing AA5083/TA31 dissimilar butt joints at different groove angles
Authors: Li Yang , Zhang Shuaifeng , Tang Xinhua , Zhang Yunhao , Zhang Maofu , Lv Yifan
Published: March 2023

Al/Ti dissimilar alloy plates with thickness of 6 mm were butt joined using the direct laser fusion brazing method. A systematic comparison of laser fusion brazing of four groups of AA5083 to TA31 plates with different groove angles ranging from 60° to 90° was performed by laser beam offsetting to the aluminum alloy side. The related weld appearance, microstructures in weld and at joint interface, defects formation mechanism and fracture resistance were analyzed and compared in detail. Preferable joint appearance, characterized by wetting the top and bottom sides of the titanium alloy with molten aluminum alloy, can be obtained except for the joints with 60° groove angles. The uniformity of intermetallic compound (IMC) morphology and thickness distribution at the interface was improved as the groove angle decreases, accompanied by a decrease in the diffusion distance of main elements at the same location. Severe interfacial crack and intergranular hot crack defects were formed in the joints with 90° and 60° groove angles, respectively. The interfacial cracks are induced by the difference in hardness and elastic modulus between TiAl3 phases and titanium base metal or aluminum weld. The hot crack defects are mainly caused by microstructure mismatch including grain size and texture orientation mismatch between the fine grain zone near the interface and the coarse grain zone inside the aluminum alloy weld. The crack-free joints with groove angles of 70° show the highest tensile strength of 268.76 MPa due to the relatively uniformly distributed and fine interfacial IMCs. This study reveals the possibility to realize efficient joining of medium-thick titanium alloy and aluminum alloy plates by using laser fusion brazing method without other auxiliary equipment.
Autophagy-enhancing ATG16L1 polymorphism improves clinical outcomes and promotes superior T-cell immunity in chronic HIV-1 infection
Authors: Schreurs Renée , Koulis Athanasios , Booiman Thijs , Boeser-Nunnink Brigitte , Cloherty Alexandra , Rader Anusca , Patel Kharishma , Kootstra Neeltje , Ribeiro Carla
Published: March 2023

Chronic HIV-1 infection is characterized by T-cell dysregulation that is only partly restored by antiretroviral therapy. Here, we demonstrate a protective role for autophagy in HIV-1 disease pathogenesis. Targeted analysis of genetic variation in core autophagy gene ATG16L1 revealed a previously unidentified polymorphism, which correlated functionally with enhanced autophagy and clinically with improved survival of untreated HIV-1-infected individuals. Intrinsically-enhanced autophagy in homozygous minor T-cells resulted in superior antiviral immunity, evidenced by increased proliferation, revamped immune responsiveness, and suppressed exhaustion/immunosenescence features. In-depth flow-cytometric and transcriptional T-helper-profiling revealed signatures unique to minor genotyped individuals with enriched regulation of pro-inflammatory networks and skewing towards immunoregulatory T-cell-phenotype. Treatment with autophagy-enhancing pharmaceuticals reprogrammed T-cells to exhibit the protective traits observed in homozygous minor donors. These data underscore the in vivo relevance of autophagy for longer-lasting T-cell-mediated HIV-1 control, with implications towards development of host-directed therapeutics targeting autophagy to restore immune function in chronic HIV-1 infection.
The Property Rights Index (PRIF) can be used worldwide to compare different forest governance systems
Authors: Rimoli Richard , Nichiforel Liviu , Acharya Aditya , Nollet Alexandre , Snoussi Bilal , Ambroise Lison , Cordonnier Louis , Mares Sandra Galván , Zúñiga José Jonathan Aguirre , Bontemps Jean-Daniel , Bouriaud Laura
Published: March 2023

The bundle of forest landowners’ rights largely varies from one jurisdiction to another. On a global scale, the diversity of forest regime and property rights systems is such that finding similarities for governance analysis purposes is a challenging task. This paper built on the Property Rights Index for Forestry (PRIF). We show that PRIF is a reliable index for various governance arrangements, from forests privately owned in Europe, in the Amazon area (Brazil), in Misiones province (Argentina) and in Quebec (Canada) to community-managed Nepalese forests. The PRIF enables us to compare accurately and efficiently the forests regime incident to different types of forest ownership on three continents with an integrative and standardised approach. Despite having a few limitations, the PRIF is a promising indicator to assess governance of the natural resources in various socioeconomic and legal contexts.