Development of a Health Behavioral Digital Intervention for Patients With Hypertension Based on an Intelligent Health Promotion System and WeChat: Randomized Controlled Trial (Preprint)
Authors: Sun Ting , Xu Xuejie , Ding Zenghui , Xie Hui , Ma Linlin , Zhang Jing , Xia Yuxin , Zhang Guoli , Ma Zuchang 
Published: September 2023

BACKGROUND

The effectiveness of timely medication, physical activity (PA), a healthy diet, and blood pressure (BP) monitoring for promoting health outcomes and behavioral changes among patients with hypertension is supported by a substantial amount of literature, with “adherence” playing a pivotal role. Nevertheless, there is a lack of consistent evidence regarding whether digital interventions can improve adherence to healthy behaviors among individuals with hypertension.

OBJECTIVE

The aim was to develop a health behavioral digital intervention for hypertensive patients (HBDIHP) based on an intelligent health promotion system and WeChat following the behavior change wheel (BCW) theory and digital micro-intervention care (DMIC) model and assess its efficacy in controlling BP and improving healthy behavior adherence.

METHODS

A 2-arm, randomized trial design was used. We randomly assigned 68 individuals aged &gt;60 years with hypertension in a 1:1 ratio to either the control or experimental group. The digital intervention was established through the following steps: (1) developing digital health education materials focused on adherence to exercise prescriptions, Dietary Approaches to Stop Hypertension (DASH), prescribed medication, and monitoring of BP; (2) using the BCW theory to select behavior change techniques; (3) constructing the intervention's logic following the guidelines of the DMIC model; (4) creating an intervention manual including the aforementioned elements. Prior to the experiment, participants underwent physical examinations at the community health service center's intelligent health cabin and received intelligent personalized health recommendations. The experimental group underwent a 12-week behavior intervention via WeChat, while the control group received routine health education and a self-management manual. The primary outcomes included BP and adherence indicators. Data analysis was performed using SPSS, with independent sample <i>t</i> tests, chi-square tests, paired <i>t</i> tests, and McNemar tests. A <i>P</i> value &lt;.05 was considered statistically significant.

RESULTS

The final analysis included 54 participants with a mean age of 67.24 (SD 4.19) years (n=23 experimental group, n=31 control group). The experimental group had improvements in systolic BP (–7.36 mm Hg, <i>P</i>=.002), exercise time (856.35 metabolic equivalent [MET]-min/week, <i>P</i>&lt;.001), medication adherence (0.56, <i>P</i>=.001), BP monitoring frequency (<i>P</i>=.02), and learning performance (3.23, <i>P</i>&lt;.001). Both groups experienced weight reduction (experimental: 1.2 kg, <i>P</i>=.002; control: 1.11 kg, <i>P</i>=.009) after the intervention. The diet types and quantities for both groups (<i>P</i>&lt;.001) as well as the subendocardial viability ratio (0.16, <i>P</i>=.01) showed significant improvement. However, there were no statistically significant changes in other health outcomes.

CONCLUSIONS

The observations suggest our program may have enhanced specific health outcomes and adherence to health behaviors in older adults with hypertension. However, a longer-term, larger-scale trial is necessary to validate the effectiveness.

CLINICALTRIAL

Chinese Clinical Trial Registry ChiCTR2200062643; https://www.chictr.org.cn/showprojEN.html?proj=172782

INTERNATIONAL REGISTERED REPORT

RR2-10.2196/46883