bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH REGULASI DIRI TERHADAP MOTIVASI AKADEMIK SISWA SMP X DI JAKARTA
Authors: Basaria Debora , Zamralita Zamralita , Margaretha Jane
Published: October 2024

The COVID-19 pandemic has impacted education, limited students' social environment and decreasing their motivation to learn. In Indonesia, 7 out of 10 students revealed that they rarely study since the introduction of social restrictions. Motivation is an important aspect in the learning process, students with high motivation will strive for the best results. Learning motivation comes from internal and external drives that change behavior. Students need good self-regulation skills to manage internal and external motivational drives. Self-regulation contributes positively to academic achievement and predicts long-term educational success. This study aims to determine the effect of self-regulation on academic motivation of SMP X students. The participants in this study consisted of 141 students aged 11-15 years. The researcher used the Academic Motivation Scale (AMS) and Personal Self-Concept (PSC) Questionnaire which have been translated into Indonesian. Results showed a significant positive effect between self-regulation and academic motivation, with R2 = 0.135, F value = 7.12, and p value of 0.00 < 0.5. This indicates higher student self-regulation correlates with higher academic motivation. Effective self-regulation strategies can help increase student motivation amid pandemic-like disruptions.
Creación de los héroes en Sorgo rojo de Mo Yan: tradiciones e innovaciones
Authors: Xiaomeng Sun
Published: October 2024

El presente trabajo expone los resultados de una investigación sobre la creación de las figuras de héroes en la novela Sorgo rojo del escritor chino Mo Yan. Se analizan las relaciones que tienen estos héroes con las narraciones tradicionales chinas como A la orilla del agua y con las novelas revolucionarias, y las innovaciones que ha introducido en los viejos sistemas de valores. Además, se aclara el papel importante que juega la anacronía en el proceso de creación de estos héroes.
Don Quijote y La tregua: un estudio de dos casos sobre la crítica traductora de la literatura hispánica en China
Authors: Jian Hou
Published: October 2024

En el proceso de la traducción, difusión y recepción de la literatura hispánica en la República Popular China se han dado varios debates de gran alcance sobre la traducción. Entre ellos los debates sobre la traducción de Don Quijote y La tregua son muy representativos. Este trabajo se concentra en el estudio de estos dos casos, con el propósito de enfatizar la importancia de la crítica traductora y la urgencia de establecer un sistema sano y académico para hacer intercambios y críticas sobre la traducción literaria.
Crecimiento del comercio y distribución de la inversión de China en México
Authors: Licona Michel Ángel , Herrera Marylin Alba , Hernández Medina Evelyn
Published: October 2024

México y la República Popular China (China), son miembros del Foro de Cooperación Económica Asia-Pacífico (APEC), así como de la Organización Mundial del Comercio (OMC), entre otras instituciones en las cuales se promueve la apertura de los mercados para lograr que sus economías tengan un mayor impulso en su crecimiento económico por medio del comercio. En esta investigación se analiza la relación bilateral y el crecimiento del comercio, así como la distribución de la inversión de China en México en las primeras dos décadas del siglo XXI, para ello trabajamos por medio de un análisis documental y de información que garantizara la recuperación selectiva de distintas fuentes para explicar le relevancia de China en el comercio de México, que le permite convertirse en el primer socio comercial de Asia-Pacífico y los flujos de inversión ganen presencia en el territorio mexicano en el siglo .
Añadir aquí la descripción de la metodología. Por ejemplo: “a través de la revisión documental de reportes/informes de la Secretaría de Economía”.
THE ETHICAL AND LEGAL ASPECTS OF HEALTH POLICY ON ELECTRONIC MEDICAL RECORDS IN INDONESIA
Authors: Larasati Ta , Fardiansyah Ahmad Irzal , Saketi Dwi , Nusa Dewiarti Azelia
Published: October 2024

The government has addressed the development of electronic medical records (RME) through Minister of Health Regulation (Permenkes) No. 24 of 2022, ensuring their legality in healthcare facilities across Indonesia. The primary goal is to integrate all patient data, enabling the Ministry of Health to map the health status of Indonesian citizens, including information about various diseases. However, principles related to medical records, particularly confidentiality, must be observed to prevent violations and guarantee the privacy of patient data, reflecting healthcare professionals' ethical responsibilities. The use of electronic medical records raises concerns about potential data leaks, necessitating the establishment of security measures and identification of responsible parties in case of breaches. Research indicates that challenges remain in implementing RME across healthcare facilities, including limited internet access and the lack of preparedness among practitioners, clinics, health centers, and hospitals. Therefore, the Ministry of Health must undertake extensive outreach and training initiatives to address these issues and enhance internet connectivity throughout the country.
PAPP-A Levels and IGF-1 Levels in Early-Onset Preeclampsia and Late-Onset Preeclampsia
Authors: Soufal Juan Habli , Yusrawati Yusrawati , Basyir Vaulinne
Published: October 2024

Introduction: The pathophysiology of preeclampsy is not yet fully understood, but failure of tropoblast invasion and placentation, which is influenced by factors such as pregnancy-associated plasma protein A (PAPP-A) and insulin-like growth factor 1 (IGF-1), is thought to play a role.
Aims: This study aimed to explore the difference in PAPP-A and IGF-1 levels between Early-Onset Preeclampsia (PEAD) and Late-Onset Preeclampsia (PEAL), assuming that the role of PAPP-A and IGF-1 is more significant in the pathogenesis of PEAD than PEAL.
Methods: This is an analytical observational study with a cross-partition comparative study design. Clinical data were obtained at Dr. M. Djamil Padang Hospital, while PAPP-A and IGF-1 levels were measured at the Biomedical Laboratory of the Faculty of Medicine, Andalas University. Samples are tested according to reagent procedures and analyzed by experts.Results: Average PAPP-A levels were 2.45+0.35 pg/mL in the early onset preeclampsy group and 2.85+0.50 pg/mL in the late onset preeclampsy group. These two levels differed statistically significantly (p=0.006). That means that low levels of PAPP-A are associated with and play a role in the pathogenesis of early onset preeclampsy. Average IGF-1 levels were 4.66+0.91 pg/mL in the early onset preeclampsy group and 5.39+0.74 pg/mL in the late-onset preeclampsy group. These two levels differed statistically significantly (p=0.010). That means that low levels of IGF-1 are associated with and play a role in the pathogenesis of early onset preeclampsy. PAPP-A levels were significantly positively correlated with IGF-1 levels (p=0.000).
Conclusion: PAPP-A levels are lower in PEAD than PEAL, as are IGF-1 levels. These findings confirm the role of PAPP-A and IGF-1 in preeclampsia. Both of these hormones have potential as indicators and markers for the prediction and management of preeclampsy in early and late onset periods.
Factors Affecting the Age of Menopause in Padang City in 2023
Authors: Bennovry Rizky Rivonda , SA Syahredi , Utama Bobby Indra
Published: October 2024

Menopause is characterized by a consecutive period of amenorrhea lasting 12 months without any underlying causes or surgical interventions. The age at which menopause occurs can be influenced by various factors, including menarche, number of childbirths, body mass index, and the utilization of hormonal contraceptives. This study aims to determine the factors that influence the incidence of menopause in Padang. This study is an analytical research with a cross-sectional study design. The research was conducted in the working areas of all primary public health centers in Padang from Januari 2023 to September 2023. The sample consisted of middle-aged women who visited the working areas of all primary public health centers during the study period. This study is using a questionnaire as the research instrument and employing the simple random sampling technique to obtain a sample size of 124 participants. The data analysis was conducted using the Chi- Square test, and utilize the statistical software SPSS. A significant relationship between variables was defined if the p-value < 0.05. The results of this study revealed that the majority of respondents experienced early menarche (36.3%), had multiparous pregnancies (33.9%), had underweight body mass index (33.1%), used hormonal contraceptives (52.4%), and experienced late menopause (40.3%). The analysis showed a significant relationship (p<0.05) between the age of menarche (p=0.036) and parity (p=0.002) with the occurrence of menopause. However, there was no significant relationship (p>0.05) between body mass index (p=0.141) and history of contraceptive use (p=0.069) with the occurrence of menopause. This study found a significant relationship between the age of menarche and parity with the occurrence of menopause, while there was no significant relationship between body mass index and history of contraceptive use with the occurrence of menopause among middle-aged women visiting the primary public health center areas in Padang.
Correlation of Maternal Serum 25 Hydroxy Vitamin D with Newborn Anthropometry
Authors: Iqbal Muhammad , Yusrawati Yusrawati , Karmia Hudila Rifa , Serudji Joserizal
Published: October 2024

Vitamin D deficiency (VDD) is identified as a public health problem in many countries, and pregnant women have been identified as a high-risk group, among whom the prevalence of VDD ranges between 20 and 40%. Vitamin D deficiency causes essential health problems, not only in the mother but also in the baby, because the mother's vitamin D stores are the primary source of vitamin D for the fetus. During pregnancy, severe vitamin D deficiency in mothers has been associated with biochemical evidence of impaired bone homeostasis, congenital rickets, and bone fractures in newborns. This study aims to determine the correlation between umbilical cord blood 25(OH)D levels in term pregnancy and Neonatal anthropometry. This research is analytical research using a cross-sectional approach. The sample in this study amounted to 40 people. Data analysts use people tests. The results of this study obtained an average umbilical cord serum 25(OH)D level of 14.70 ± 4.93. There was no correlation between umbilical cord blood 25(OH)D levels in term pregnancy and neonate anthropometry (p>0.05). The average level of 25(OH)D is included in the insufficiency category. Therefore, it is necessary to increase vitamin D supplementation during pregnancy.
The Relationship of Vitamin D Topolycystic Ovary Syndrome (PCOS) Teenagers at Koto Tangah Padang District High School in 2022
Authors: Utomo Hardi Cahyo , Yuad Haviz , Burhan Ida Rahmah
Published: October 2024

PCOS is characterized by increased ovarian and adrenal androgen secretion, hyperandrogenic symptoms such as hirsutism, acne and/or alopecia, menstrual irregularities, and polycystic ovaries. The prevalence of PCOS in 2016 was 6−21% of reproductive age worldwide. PCOS is the most common female endocrine disorder with a prevalence of around 4-6% in women of reproductive age in Indonesia. Vitamin D deficiency can increase PCOS symptoms. The research design was cross-sectional. The study was conducted at SMA N 7, SMA N 8 and SMA N 13 Padang in Koto Tangah District in May-August 2022. The research sample was high school students who experienced menstrual cycle disorders and were willing to agree to informed consent for the study with a sample size of 59 respondents. Vitamin D levels were examined using the 25-Hydroxyvitamin D ELISA Kit. Data were analyzed by chi-square test. The results showed that 86.4% of respondents experienced vitamin D deficiency. Statistically there was a relationship between PCOS in adolescents accompanied by hyperandrogens and vitamin D levels, there was a relationship between PCOS in adolescents accompanied by obesity and vitamin D levels, there was no relationship between PCOS in adolescents accompanied by acanthosis nigrican and vitamin D levels, and there was no relationship between PCOS in adolescents accompanied by hyperandrogens, obesity and acanthosis nigrican with vitamin D levels in SMA Koto Tangah District Padang in 2022. The conclusion of this study is that there is a relationship between PCOS in adolescents accompanied by hyperandrogens and vitamin D levels and there is a relationship between PCOS in adolescents accompanied by obesity and vitamin D levels.
Morphological and anatomical characteristics and DNA barcode of Vanilla tiendatii
Authors: Mai Yen Hoa , Phan-thi Doan Trang , Truong Duy Hoang , Trinh Ngoc Nam , Tran-thi Thu Trang , Nguyen-Phi Nga , Van Hong Thien
Published: October 2024

Vanilla tiendatii is a rare species and it has only been found in Quy Dat town, Minh Hoa district, Quang Binh Province, Vietnam. In this study, the detailed anatomical characteristics of this species were provided for the first time. Furthermore, five molecular markers, including ITS, psaB, psbB, psbC, and matK were firstly successfully sequenced. The lengths of these regions were ranging from 606 to 730 bps. They were deposited in the NCBI database with the accession numbers of PP696975, PP721190, PP721191, PP721189, and PP721188, respectively. The results also demonstrated that there were differences in these molecular markers between V. tiendatii and other Vanilla species, V. yersiniana and V. albida, which were similar in morphological characteristics.
Intra-articular lipoma of the hip joint – A report of two cases and literature review
Authors: Mettu Sindhura , Gavvala Sai Niharika , Iyengar Karthikeyan P. , Papineni Vijay Ram Kumar , Botchu Rajesh
Published: October 2024

Intra-articular lipoma of the hip joint is a rare entity with a mere 4 cases being reported to date We present two patients with true intra-articular hip lipomas, with insidious onset of non-traumatic hip pain and gradual restriction in the range of motion. Magnetic Resonance Imaging (MRI) revealed an encapsulated intra-articular lesion with the typical imaging characteristics of a benign lipomatous tumour and a similar signal as that of fat tissue.. Arthroscopic excision of the intra-articular lipoma was done in one patient. An intra-articular lipoma is a rare synovial tumour of the hip joint with typical imaging characteristics and this article highlights clinical presentation, radiological features, and management options.
Microscopic Thyroidectomy and Its Outcomes: Retrospective Analysis of 25 Cases
Authors: Palled Kavitha Prakash
Published: October 2024

Objectives:

To evaluate the clinical outcomes of 25 patients undergoing microscopic thyroidectomy, focusing on demographic details, perioperative complications, and postoperative results, with specific attention to recurrent laryngeal nerve (RLN) palsy and hypocalcaemia.

Material and Methods:

A retrospective analysis was conducted at Apollo Hospital, Mysore, on 25 patients who underwent microscopic thyroidectomy. Demographic data (age, gender, and diagnosis) were recorded. Postoperative complications, such as RLN palsy and hypocalcaemia, were assessed through clinical evaluation, direct laryngoscopy, and biochemical markers. Data were analyzed and presented in tabular form.

Results:

Of the 25 patients, 18 were female (72%) and 7 were male (28%), with an average age of 48.2 years. Diagnoses included 16 benign (64%) and 9 malignant (36%) cases. Transient hypocalcaemia occurred in 3 patients (12%) and transient RLN palsy in 1 patient (4%), both resolving within three months. No permanent complications were noted. The average operative time was 110 minutes (95 minutes for hemithyroidectomy, 130 minutes for total thyroidectomy). Average intraoperative blood loss was 35 mL, and the average hospital stay was 2.5 days. Histopathological analysis confirmed clear margins in all malignant cases.

Conclusion:

Microscopic thyroidectomy is a safe and effective procedure with minimal complications, particularly in preserving the RLN and parathyroid glands. Its precision leads to faster recovery and favorable postoperative outcomes, making it a valuable option in thyroid surgery.
Credit hours and continuing medical education (CME) programmes
Authors: BHATTACHARYA SURAJIT , BHATTACHARYA KAUSHIK
Published: October 2024

Continuing medical education (CME) credits has been mandated by the National Medical Commission for registered medical practitioners in India as a part of continuing professional development and a minimum of 30 credits in 5 years is required for the renewal of the medical license. Undoubtedly, credit hours for CME attendance is an essential yardstick for professional and career growth, the modus operandi adopted to grant these credit hours needs a serious look. Targeted learning with adequate feedback either with a post CME examination or questionnaire should become the norm and every publication in high impact indexed journal deserve a higher credit point than the rest of the publications.
Home-Based HIFT Altered Quality of Life and Health Related Fitness Parameters in Women
Authors: Uysal Alp Aslan , Bereket Yücel Selda
Published: October 2024

The effects of high intensity functional training (HIFT) on health related components of fitness and quality of life were studied in the gym environment, but there has not been any study on examining the effects of HIFT by using bodyweight exercises at home environment on health related components of fitness and quality of life in women. The goal of this research is to examine the effects of home-based bodyweight HIFT on health related components of physical fitness and quality of life in women. Twenty-one recreationally active female participants (age 26.3 ± 3.7 years) were included in the study. After completing the pretest, participants applied HIFT at home with bodyweight exercises three times a week for a duration of eight weeks. Cardiovascular endurance, muscular strength, muscular endurance, flexibility, body composition and quality of life assessments were carried out in both pretest and posttest applications. Significant differences were observed between the pretest and posttest results of cardiovascular endurance (p=0.042), muscular strength (p<0.001), muscular endurance (p<0.001) and flexibility (p=0.001) parameters. No significant difference was observed between the pretest and posttest results of body composition analysis. Significant improvement (p=0.045) was found on the quality of life scale. Home-based bodyweight HIFT altered quality of life in recreationally active women and enhanced health related components of fitness, which could prevent the increase of health-related risk factors caused by inactivity.
Characteristics of sublittoral vegetation at the northwestern coast of the Japan Sea based on the concept of adaptive zone
Authors: Dulenin A. A.
Published: October 2024

On materials of the diving survey conducted in 2010, using additional data obtained from 1999 to 2023, sublittoral vegetation at the northwestern coast of the Japan Sea is described. Basing on the concept of adaptive zone, 16 associations are identified (Ulvetum fenestratae, Saccharinetum japonicae, S. cichorioidae, Kjellmanielletum crassifoliae, Costarietum costariae, Agaretum clathratae, Desmarestetum viridae, Sargassetum miyabeae, S. pallidae, Stephanocystetum crassipae, Bossielletum compressae, Ptilotetum asplenioidae, Odonthalietum corymbiferae, Zosteretum marinae, Z. asiaticae, Phyllospadicetum iwatensis) and a group of communities of encrusting calcareous algae. These associations are not abstract classification units, but mosaics of homogeneous adaptive zones of their main dominants considered as elementary Petersen-type communities where on average 58 % of bottom cover and 53 % of biomass are formed by the main dominant species. The associations of the upper layer can be identified visually, with assessing the projective coverage of main dominants and subdominants for each of them using underwater drones. Visual identifying for subordinate species is less available, as well as quantitative assessment of their coverage. The total area occupied by the vegetation associations is 217 km2 , i.e. about 2/3 of the total vegetation belt. The total biomass of vegetation within the associations is estimated as 1248 . 103 t, of which the biomass of the main dominants is 709 . 103 t. Commercial and potentially commercial resources of macrophytes are generally confined to their associations, that allows to estimate the total stock in 324 . 103 t, including 94 . 103 t of the only commercially used species Saccharina japonica. These stock values have no statistically significant difference from earlier estimations (p = 0.79), that approves using the concept of adaptive zone for assessment of commercial resources of subtidal vegetation.
Bottom-pelagic links of hydrobionts in the Kara Sea according to data on δ15N and δ13C and feeding of fish
Authors: Gorbatenko K. M. , Melnikov I. V.
Published: October 2024

To compare trophic properties in pelagic and benthic communities of the Kara Sea, isotopic composition of carbon and nitrogen (δ13C and δ15N) was examined in tissues of zooplankton, zoobenthos, and fish. The organisms exhibited rather low δ13C values in the surveyed area. Because of stable difference in isotopic composition of carbon for zooplankton and zoobenthos, the pelagic and benthic communities could be separated by the level δ13C = –21.5 ‰, on average. The δ15N values for these communities varied within their 3 trophic levels in the range from 6.4 ‰ (for bivalve Serripes groenlandicus) to 16.3 ‰ (for lycod Lycodes seminudus), reflecting the input of predation. The bottom and pelagic communities in the Kara Sea demonstrated trophic interdependence. Both pelagic and bottom fish species, more or less, consumed both pelagic and benthic prey. Taking into account the content of 13C isotope in tissues of zooplankton and zoobenthos, about 40 % of the bottom nekton species were linked mainly with the pelagic food web and bypassed the benthic one. Pelagic fish fed mainly on pelagic prey, though the portion of zoobenthos in food of the dominant species — arctic cod had increased with the fish size increasing. On the contrary, the portion of zoobenthos in food of ruffed flounder had decreases with their size.
On introduction of Black Sea mussel Mytilus galloprovincialis (Lamarck, 1819) to the Caspian Sea basin
Authors: Minakova E. V. , Zhatkina O. V. , Kashin R. D. , Mikhailova A. V. , Kozlova N. V. , Tikhonova E. Yu.
Published: October 2024

Large-sized specimens of a new for the Caspian Sea mollusk were found in spring 2023 in trawl catches of the survey conducted by the Volga-Caspian branch (CaspNIRKH) of the Russian Res. Inst. of Fisheries and Oceanography. Using molecular genetics research methods, including sequencing of the cytochrome oxidase gene of mitochondrial DNA, the species is identified as Mytilus galloprovincialis — the Black Sea mussel. In summer, the invaders were recorded in bottom samples in several areas of the sea. Features of the species biology allow its naturalization into the Caspian Sea ecosystem that will contribute to enrichment of the food base for fish and involve this filter-feeding mollusk to the processes of self-purification of the sea.
Merging Photoexcited Nitroarenes with Lewis Acid Catalysis for the Anaerobic Oxidation of Alkenes
Authors: Paolillo Joshua , Saleh Mahmoud , Junk Ethan , Parasram Marvin
Published: October 2024

A protocol for the oxidation of alkenes to carbonyls and acetonides via the interplay of photoexcited nitroarenes and Lewis acid catalysis is described. Terminal 1,1-disubstitued alkenes were oxidized selectively to the aldehyde products, while tri- and tetrasubstituted alkenes generated ketone products with anti-Markovnikov selectivity. Terminal mono-substituted alkenes were oxidized to acetonides when acetone was employed as a co-solvent. The mild conditions of the reaction allow for a wide range of alkenes to be oxidized. Mechanistic studies support that Lewis acid coordination to the 1,3,2-dioxazolidine intermediate formed by irradiation of the nitroarene and alkene results in a Meinwald-like rearrangement to generate carbonyl derivatives. In the presence of acetone, acetonides are formed from the same intermediate through a nucleophilic substitution pathway.
Enhancing Reverse Intersystem Crossing with Extended Inverted Singlet-Triplet (X−INVEST) systems
Authors: Ricci Gaetano , Landi Alessandro , Sancho Garcia Juan Carlos , Olivier Yoann
Published: October 2024

The discovery of triangular-shaped organic molecules bearing an inverted singlet-triplet (INVEST) energy gap opened the way for a new strategy to increase the internal quantum efficiency of organic light-emitting diodes by enhancing the Reverse Intersystem Crossing (RISC) process thanks to a downhill process. However, all the molecular systems showing a negative ΔEST suffer from both a vanishing Spin-Orbit Coupling between the lowest singlet (S1) and triplet (T1) excited states and high energy differences with higher-lying singlet and triplet excited states, precluding their involvement in the spin conversion process. In this work we proposed a new design strategy entailing the extension of the triangulene cores by connecting two INVEST triangulene units to form Uthrene- and Zethrene-like systems, doped with N and B atoms. A detailed inspection of the resulting molecular orbital distribution allowed rationalizing the electronic structure properties obtained employing wavefunction-based methods (NEVPT2, EOM-CCSD, SCS-CC2), showing how the Uthrene-like architecture can give origin to the energy proximity between the lowest singlet and triplet excited states, in some cases leading to their energy inversion. By feeding a kinetic model with the non-radiative rate constants calculated from first principle we showed how the Extended INVEST (X−INVEST) design strategy can open new pathways to boost the spin conversion process and the population of the emissive S1 excited state.
Hybrid Polarizing Solids with Extended Pore Diameters for Dissolution Dynamic Nuclear Polarization
Authors: Pokochueva Ekaterina V. , Le Nghia H. , Guibert Sylvie , Gioiosa Chloé , Stern Quentin , Tolchard James , Bocquelet Charlotte , Cala Olivier , Cavaillès Matthieu , Veyre Laurent , Mankinen Otto , Telkki Ville-Veikko , Thieuleux Chloé , Jannin Sami
Published: October 2024

Dissolution dynamic nuclear polarization has emerged as a powerful technique to address the inherent sensitivity limitations in nuclear magnetic resonance imaging and spectroscopy. The technique relies on the use of stable paramagnetic polarizing agents that act as a source of hyperpolarization but unfortunately their presence contaminates the sample and significantly enhances paramagnetic relaxation of the hyperpolarized solutions. In the last decade, novel sample formulations have been proposed to combat this issue, including silica-based hybrid polarizing solids (HYPSO), which have enabled the production of contamination-free hyperpolarization. Here, we present a new generation of polarizing solids with pore diameters increased from 4 nm up to 28 nm. Compared to the previously described HYPSOs with smaller pore sizes of 4 nm, larger pores ultimately achieve the ambitious contradictory goals of i) providing rapid and high solid-state polarization and improving cross-polarization efficiency, while ii) decreasing hyperpolarization losses upon melting, transfer, and filtration, and iii) reducing the overall concentration of the polarizing agent by a factor of 2. These HYPSO materials can be used in virtually any existing dDNP settings without modification, apart from the sole addition of an in-line commercial filter to retain the HYPSO powder upon dissolution and transfer.
Fabrication of Low-Cost, High-Resolution Open Capillary Microfluidics towards Self-Sustaining, Long-Term Hydration of Engineered Living Materials
Authors: Sun Aileen Y. , Lin Carrie H. , Tatka John A. , Drake Kinsey , Daily Shannon , Castellanos Megan , Nelson Alshakim , Olanrewaju Ayokunle O.
Published: October 2024

Engineered living materials (ELMs) are an emerging class of biohybrid materials that have shown great promise with advanced capabilities unachievable by conventional materials. However, application of ELMs outside of the laboratory has been limited due to the need for periodic media replenishment or complete media immersion. We herein demonstrated the integration of capillary microfluidics for the autonomous and pump-free hydration of ELM hydrogels. We optimized 3D printing parameters, including exposure time and build plate lift and retract distances, to obtain microchannel dimensions capable of spontaneous capillary flow using a low-cost liquid crystal display stereolithographic apparatus (LCD-SLA) 3D printer and two hydrogel resins that are suitable for ELMs. Microchannel dimensions were accurate with ≤ 10% deviation between designed and measured widths and precise with coefficients of variation (CVs) <5% for microchannels ≥ 206.4 μm. We demonstrated proof-of-concept spontaneous capillary flow in 3D printed microfluidic devices using dye-incorporated lysogeny broth (LB). Snapshots of the devices captured up to 24 hours showed the diffusion of dye-incorporated LB throughout the bulk material. Through this proof-of-concept study, we have showcased the feasibility of integrating capillary microfluidics with ELMs for the autonomous and pump-free flow of fluids towards self-sustaining and long-term hydration.
Z-Selective Alkyne Transfer Semihydrogenation in Drug-Like Molecules via an Organic Photoreductant
Authors: Bissinger Benjamin R. G. , Vu Dang H. , Janning Henric F. , Wiesenfeldt Mario Patrick
Published: October 2024

The deactivation of transition metal catalysts poses a significant challenge when applying synthetic methods to medicinal chemistry, where Lewis-basic functional groups based on nitrogen and sulfur are prevalent. C–C multiple bond reduction reactions usually depend on Lewis-acidic metal hydrides with open coordination sites that render them incompatible with such functional groups. Reduction mechanisms that replace the Lewis-acidic transition metal with an organic reductant offer a potential solution to this issue. Indeed, reactions via organic hydrides and photoredox catalysts have shown a broad tolerance of Lewis-basic motifs but remain restricted to the reduction of highly electrophilic Michael acceptors. Herein, we report the development of a mechanistically distinct transformation using an organic photoreductant that can be applied to the reduction of unpolarized alkynes. The reaction tolerates most medicinally relevant functional groups including highly Lewis-basic motifs like tetrazoles, guanidines, and triazoles, which have never been tolerated in an alkyne semihydrogenation before. Overreduction is minimized by controlling the redox potential and the high Z-selectivity is ensured by steric matching during association between reduced intermediates and reductant thus mimicking the transition metal mediated mechanism.
Molecule/quantum dot orbital hybridisation harnesses endothermic singlet exciton fission
Authors: Zhang Jie , Sakai Hayato , Suzuki Katsuaki , Khan Ramsha , Hasobe Taku , Chang I-Ya , Hyeon-Deuk Kim , Kaji Hironori , Sakamoto Masanori
Published: October 2024

Singlet exciton fission (SF) is one of the limited options for exceeding the theoretical limit of solar energy utilisation, the so-called Shockley–Queisser limit. Thus, improving endothermic SF efficiency will significantly contribute to the efficient utilisation of solar energy beyond the existing technology. In this regard, combining SF molecules with quantum dots (QDs) has achieved excellent results. However, the factors underlying the enhanced SF efficiency remain poorly understood. Herein, we discovered that inter-material orbital hybridisation between SF molecules and QDs harnesses endothermic SF. Theoretical calculations and transient absorption measurements of tetracene (Tc)–CdX (X = Te, Se, S) QD composites showed that multiple orbital hybrid levels formed by orbital hybridisation act as intermediate levels to facilitate SF. This result sheds light on alternative factors affecting SF efficiency beyond the molecular packing of SF molecules on the QD surface. The synergy effect on the zero-dimensional molecular assembly on QDs will provide guidance for the development of organic-inorganic hybrid solar cells, which overcome the Shockley–Queisser limit.
Hexagonal boron nitride as a two-dimensional surfactant: low-density flame-resistant composites based on boron nitride exfoliated by an interface trapping technique
Authors: Chapman Christopher , Srivastava Deep Shikha , Ward Shawn , Cui Zhenhua , Adamson Douglas
Published: October 2024

Hexagonal boron nitride (hBN) is a two-dimensional material isoelectric to graphene. It has a hexagonal structure with alternating boron and nitrogen atoms and is electrically insulating, thermally conductive, and chemically inert. However, like graphene, its use as a functional nanofiller requires exfoliation. Here, we present a method for exfoliating and dispersing hexagonal boron nitride (hBN) sheets within a polymer matrix. This is achieved by a solvent interface trapping method (SITM), where hBN exfoliates and spreads at a high-energy oil/water interface, separating the two phases and lowering the system's free energy. hBN thus acts as a surfactant, allowing us to form stable water-in-oil emulsions stabilized by films of overlapping hBN sheets. Polymerizing the continuous oil phase results in polymerized high internal phase emulsions (polyHIPE) with the foam cells lined with hBN. In the investigation presented here, we use acoustic spectroscopy, optical and electron microscopy, and image analysis to study emulsion and polyHIPE formation mechanisms. We find that the amount of hBN used, the flake size of the hBN, the mixing time, the type of initiator used, and the oil-to-water ratio all play a role in the morphology of the final polyHIPE. Lastly, we demonstrate the flame-retardant properties of the hBN polyHIPEs and show that at 1 % loadings, the presence of hBN prevents dripping and relighting of the composites, even when the material is heated to a red glow.
Fast and Effective Preparation of Highly Cytotoxic Hybrid Molecules of Schweinfurthin E and OSW-1
Authors: Schelle Baptiste , Fargier Jules , Grisel Clément , Askenatzis Laurie , Gallard Jean-François , Desrat Sandy , Bignon Jérome , Roussi Fanny , Norsikian Stephanie
Published: October 2024

Herein, we present the first synthesis of hybrid molecules combining the pharmacophores of two natural compounds, schweinfurthin E (SW-E) and the glycosidic moiety of OSW-1. These hybrids were designed leveraging the complementary binding of SW-E and OSW-1 to their biological target. The synthetic process highlights, in particular, one-pot functionalization and glycosylation of an L-arabinose unit using a D-xyloside donor and a CuAAC click reaction involving a polyfunctionalized prenylated stilbene derived from SW-E.
Ruta para el desarrollo de competencias comunicativas del programa de ingeniería industrial. Una apuesta desde la transversalidad del currículo central
Authors: Cancelado Helena , Lobato Osorio Lucila
Published: October 2024

El Outcome 3 de ABET, que abarca competencias comunicativas en lectura, escritura y oralidad, es crucial en la carrera de ingeniería industrial. La investigación de los departamentos de Ingeniería Industrial y Lenguaje de la universidad diseñó una ruta para introducir, alinear y valorar estas competencias en español. Utilizando teorías de alfabetización académica y análisis del discurso, se identificaron cursos con actividades dependientes de estas competencias y se ajustó la ruta de Assessment. Se alinearon los indicadores del Outcome 3 con las competencias CDIO y las competencias de comunicación del currículo central, valoradas mediante el proceso AVAC. La ruta transversal propuesta fortalece las competencias comunicativas en el programa de ingeniería industrial, integrándolas de manera estructurada en el currículo. Establece objetivos claros, identifica cursos relevantes y define criterios de evaluación alineados con estándares internacionales. Este enfoque garantiza que los estudiantes adquieran habilidades esenciales en lectura, escritura y oralidad, preparándolos para enfrentar los desafíos profesionales. La evaluación continua mediante AVAC asegura la calidad del programa educativo, contribuyendo al cumplimiento de los estándares de ABET, CDIO y AVAC
El análisis formal de conceptos y la gestión de interesados en la mejora continua del programa de ingeniería electrónica de la Universidad del Quindío
Authors: Aldana Gutiérrez Jorge , Vera Tasamá Alexander , Marín Hurtado Jorge Iván
Published: October 2024

Las dinámicas del entorno ofrecen permanentemente oportunidades de mejora para las empresas, lo que implica activar procesos de investigación alrededor de ellas. Hacia esta perspectiva, este trabajo propone un modelo de análisis para generar estrategias de mejora continua, con base en la gestión de interesados de la gerencia de proyectos bajo los fundamentos del PMBOK y el análisis formal de conceptos (FCA), a través de sus implicaciones y asociaciones. La alineación de los elementos empresariales como planes estratégicos, programas, entre otros, en un modelo de análisis con elementos del entorno (tecnologías, modelos, oportunidad, amenazas, etc.), a través de la cual se evidencie la participación de los elementos internos empresariales en los entornos, generaría insumos para oportunidades o mejoras. Este modelo se implementó en un programa académico de la Universidad el Quindío, en el contexto del pensamiento de la sostenibilidad orientado al aprovechamiento de los recursos de la Sexta Ola de Innovación Tecnológica (SOIT), buscando la alineación de los elementos del Proyecto Educativo de Programa (PEP) con las cinco ideas de soporte para la SOIT, mostrando una gama de oportunidades de mejora y propuestas innovadoras para el programa, destacándose las relaciones encontradas entre el currículo y tendencias tecnológicas como la eficiencia energética, energías renovables, el internet de las cosas, entre otros. Así mismo, con base en el análisis propuesto, los perfiles del programa académico mostraron articulación con las tendencias del entorno desde su modelo y base curricular.
Determinación y análisis integral de la calibración de una máquina extrusora para la producción de elementos estructurales con plástico reciclado (PP, HDPE y PET)
Authors: Salom Corrales Mario Antonio , Romero Restrepo Andrés David
Published: October 2024

Este proyecto se centra en el estudio de una máquina extrusora utilizando plástico reciclado, con el objetivo de encontrar materiales de construcción ecológicos. Aunque el concreto es fundamental en la construcción, su fabricación contribuye significativamente a la contaminación ambiental y al calentamiento global. Simultáneamente, la contaminación por plástico aumenta diariamente, y su producción representa al menos el 4.5% de las emisiones globales de CO2. Además, la disposición de plásticos en rellenos sanitarios genera 253 g CO2 e/kg de plástico. El proyecto propone el uso de plástico reciclado en la construcción para mitigar estos problemas ambientales. Los materiales plásticos seleccionados para este proyecto son PET (tereftalato de polietileno), PP (polipropileno) y HDPE (polietileno de alta densidad). Para utilizar estos materiales en futuras construcciones, es esencial comprender sus propiedades mecánicas. Por lo tanto, se utilizó una extrusora que trabaja a temperaturas de hasta 400°C para fabricar moldes conforme a la norma ASTM D695-15. Esta norma establece la metodología para determinar las propiedades mecánicas de plásticos rígidos, reforzados y no reforzados. El propósito de fabricar moldes y realizar pruebas mecánicas de compresión y flexión es calibrar la máquina extrusora. Esta calibración es crucial, ya que la máquina opera con una combinación específica de velocidad del tornillo y temperatura del barril para extruir el plástico de manera óptima. Al realizar pruebas mecánicas en las muestras de plástico obtenidas de los moldes, se pueden identificar las mejores propiedades mecánicas del material. Estos resultados son vitales para ajustar la velocidad y temperatura de la máquina extrusora y así lograr la calidad deseada en la extrusión del plástico. Para encontrar estos parámetros calibrados, se diseñó un modelo de ensayo con 200 combinaciones de velocidad y temperatura de fabricación en la máquina para los tres tipos de plástico (PP, PET, HDPE). Encontrándose que la resistencia a la compresión del PET es de 3.9 Mpa. En cuanto a la velocidad óptima y temperatura óptima, se tiene que esta combinación es la que se funde a 240°C con una velocidad de 80 rpm.
Análisis estocástico multidimensional para la determinación de desencadenantes de la gentrificación
Authors: Álvarez Taborda Valentina , Vélez Bolivar Marco , Oduber Anne , Martínez Crespo Jenny , Ospina Correa Juan David
Published: October 2024

La gentrificación es un proceso dinámico que describe fenómenos migratorios de grupos de mayor poder adquisitivo hacia zonas urbanas y rurales de bajos ingresos, que genera desplazamientos, cambios en las dinámicas socioculturales locales, transformación urbana y alteraciones en la calidad de vida de la comunidad. En Medellín se pueden observar procesos de gentrificación en sectores como Estación Villa, San Benito, Sevilla o El Chagualo, donde es visible la degradación del territorio por inacción administrativa, desarraigo cultural, favoreciendo el surgimiento de nuevos proyectos comerciales o inmobiliarios, una vez el sector pierde valor comercial. Santa Elena, uno de los cinco corregimientos de Medellín y con mayor presencia de bosques tropicales húmedos, está experimentando importantes transformaciones que han potenciado dramáticamente la revalorización inmobiliaria, cambios demográficos, desplazamientos de las comunidades campesinas locales, transformaciones ambientales y considerables efectos sobre los recursos ecosistémicos. Si bien, las administraciones públicas promueven medidas de regulación y control (políticas de vivienda asequible y preservación del patrimonio cultural y arquitectónico), evaluar las dinámicas de gentrificación todavía es un proceso desafiante debido a la presencia de mercados especulativos y a las tendencias de grupos sociales y de tribus urbanas. En este sentido, los avances recientes en la ciencia de datos ofrecen nuevas formas de modelar procesos socioespaciales complejos, permitiendo predicciones sobre cómo, dónde y cuáles serán los principales desencadenantes de la gentrificación. Al considerar descripciones empíricas y esfuerzos teóricos previos para comprender el fenómeno de la gentrificación, este trabajo se presenta un enfoque estocástico multidimensional, alimentado teóricamente a través del uso de sistemas de información geográfica, para analizar procesos dinámicos que promueven la evolución del fenómeno, patrones existentes y oportunidades para un desarrollo urbano inclusivo y sostenible. Este enfoque permite explorar la relación entre la gentrificación y fenómenos globales como las políticas urbanas neoliberales y el colonialismo, que permitirá resaltar la compleja interacción entre las dinámicas locales y las tendencias globales relacionadas con el uso de plataformas digitales dedicadas a la oferta de alojamientos con poca o ninguna regulación que favorezca la población nativa y su economía.
Planificación y control dinámico para la gestión de riesgos en cadenas bayesianas de suministros del sector de la construcción
Authors: Bedoya Sepulveda Vladimir , Vélez Bolivar Marco Antonio , Ospina Correa Juan David , Martínez Crespo Jenny
Published: October 2024

Factores dinámicos como la variación en costos de producción, cambios repentinos durante la fabricación, pérdida de clientes, cambios abruptos en la demanda de suministros y desestabilización de la relación con proveedores afectan dramáticamente la cadena de suministros de las organizaciones hoy en día. Estos factores están modulados por variables operacionales como deficiencias en la planeación, desaciertos en la implementación de estrategias de mercado, bajos estándares de control, obsolescencia tecnológica, entre otros. En Colombia, eventos sistemáticos como el deterioro de la malla vial, interrupciones repentinas de las operaciones, la volatilidad en los precios de combustibles y el deterioro del medio ambiente producido por el incremento de la contaminación atmosférica, aumentan aún más la incertidumbre en la planificación de las operaciones. Específicamente, en el sector de la construcción, el manejo de materias primas, la emisión de gases de efecto invernadero y el agotamiento de recursos naturales no renovables generan desafíos adicionales para el cumplimiento de las regulaciones ambientales, obstaculizando el manejo eficiente en las cadenas de logística. Estrategias como las metodologías Lean Manufacturing, Análisis DOFA y sistemas de información, buscan disminuir la incertidumbre en la planificación de la cadena de suministros. Sin embargo, su implementación está limitada por factores como la complejidad logística, integración de sistemas, acceso a tecnología, costos de operación y caracterizaciones superficiales del proceso, particularidades del contexto colombiano. En este sentido, en este trabajo presentamos una revisión crítica de los marcos de planificación convencionales, sus desafíos durante la toma de decisiones y, en consecuencia, proponemos un enfoque de evaluación a través de la minimización dinámica del riesgo en cadenas Bayesiana de suministro, como estrategia operativa que considera la planificación, el control de fabricación y las capacidades de gestión, proporcionando mayor flexibilidad y control en el sector de la construcción. Esta aproximación permite implementar formas asertivas para el planteamiento de actividades y mitigar los riesgos que se presentan en la cadena de suministro de la región.
Crossing the Rubicon: The Munich Syndrome and Forcing Israel to Peace, 1970-1978
Authors: Kurt Menderes
Published: October 2024

Munich Syndrome has been considered a constraint in the peace process decision-making of Israel. By raising questions such as what obstructs peacemaking in Israel, its costs, and whether it can force peace, the study employs the Munich analogy as a “historical lesson” method to examine why and how peace has turned into an anomaly in Israel. The Munich Agreement of 1938 by Britain and France, amid raging anti-Jewish violence in Europe, sought to appease Adolf Hitler by acquiescing to the German occupation of Czechoslovakia to prevent the world war outbreak, which, however, backfired and emerged as a metaphor for foreign policy decision-making weakness. This historical lesson has impacted Israeli society’s and its leaders’ attitudes towards peace, turning it into a Rubicon line. The study uses the 1970-1978 Arab-Israeli peace process as a case study to explain how the Munich Syndrome impedes peacemaking decisions and potential ways of overcoming it. It argues that a possible way to encourage Israel to make peace with its adversaries is with third parties providing significant concessions and guarantees.