bluuebunny/crossref_metadata_2025 huggingface dataset:
The actuality and influences of undergraduates’ participation in high impact educational practices in Chinese universities
Authors: Ke Hu , Jianchao Ni , Xiaojing Li , Xiting Zhou
Published: August 2022

High Impact Educational Practices (HIPs) are effectively educational practices that have an important impact on student learning and development. The purpose of this study is to investigate the impact of different types of high-impact educational activities on students’ learning outcomes. The data comes from the 2019 “tracking research survey on learning and development of Chinese college students,” in which undergraduates from 39 Chinese colleges and universities participated. This study first clarified the concept and classification of high-impact educational activities, and then used multiple linear regression analysis to analyze the impact of three types of high-impact educational activities, including extended learning activities, research-related activities, and social practice activities, on students’ learning gains. It’s found that most Chinese college students do not perform well on HIPs, while the “Double First-Class” university students engage more than other colleges. Participating in HIPs has a significant impact on students’ knowledge, ability and values, especially on the latter two. This study provides valuable enlightenment for universities on how to promote students’ participation in high impact educational activities and improve the quality of higher education.
Longitudinal associations of parent-child communication, dating behaviors, decision-making processes, and sex initiation among United States Latina/o adolescents
Authors: Cabral Patricia , Wallander Jan L. , Elliott Marc N. , Schuster Mark A.
Published: August 2022

Objective

This study examined differences and identified developmental predictors of oral, vaginal, and anal intercourse initiation across generational status among Latina/o adolescents of both genders. More specifically, we compare generational status and gender differences in the longitudinal predictions from parent-child sex communication and dating behaviors to sex initiation 5 years later, and how these associations may be mediated by perceived peer norms, intentions, and attitudes regarding sex among Latina/o adolescents.

Methods

Using prospective longitudinal data from the Healthy Passages™ project collected in Houston and Los Angeles, Latina/o girls (n = 879) and boys (n = 885) who were identified as 1st- (18%), 2nd- (58%), or 3rd (24%)-immigrant generational status reported on their dating behaviors and parent-child communication about sex at 5th grade (M age = 11.12 years), their perceived peer norms and attitudes regarding sex at 7th grade (M age = 13.11 years), and if they had initiated oral, vaginal, or anal sexual intercourse by 10th grade (M age = 16.06 years).

Results

Third-generation Latina girls were more likely than 1st- and 2nd-generation Latinas to have initiated sexual intercourse by 10th grade. More advanced dating behaviors in 5th grade had a positive association with sex initiation for all generational status groups among Latino boys, but only among 1st-generation Latina girls. Moreover, mediating decision-making processes of peer norms and attitudes differed for each group.

Conclusion

Pre-adolescent dating behaviors are associated with long-term differences in adolescents’ sexual behaviors, which may point to targets for prevention efforts. Acculturation differences may contribute to different ways in which adolescents decide to engage in sexual intercourse based on the previous dating experiences.
Benefits of group compassion-focused therapy for treatment-resistant depression: A pilot randomized controlled trial
Authors: Asano Kenichi , Tsuchiya Masao , Okamoto Yoko , Ohtani Toshiyuki , Sensui Toshihiko , Masuyama Akihiro , Isato Ayako , Shoji Masami , Shiraishi Tetsuya , Shimizu Eiji , Irons Chris , Gilbert Paul
Published: August 2022

Major depression is one of the most common mental health problems worldwide. More than one-third of patients suffer from treatment-resistant depression (TRD). In this study, we explored the feasibility of group compassion-focused therapy (CFT) for TRD using a randomized controlled trial with two parallel groups. Eighteen participants were randomly allocated to the intervention group (CFT and usual care) and control group (usual care alone) and a participant in each group withdrew. Participants in the intervention group received a 1.5-h session every week for 12 weeks. The effects of the intervention on the participants’ scores were calculated using a linear mixed model. There was a larger reduction in their depressive symptoms and fears of compassion for self and a greater increase in their compassion for self compared to the control group participants. The reliable clinical indices showed that in the CFT (intervention) group, three of nine participants recovered (33%), two improved (22%), two recovered but non-reliably (22%), and the condition of two remained unchanged (22%). These findings indicate adequate feasibility of group CFT for TRD in Japanese clinical settings.

Clinical trial registration

[https://clinicaltrials.gov/], identifier [UMIN 000028698].
How do Internet moms raise children? The reshaping of Chinese urban women’s parenting psychology by COVID-19 online practices
Authors: Zhao Ru , Ju Gaofei
Published: August 2022

With the acceleration of social transformation and “mediatization,” urban women’s parenting practices have become an important factor affecting the demographic structure and national development. The global COVID-19 pandemic has further contributed to the networking of social life and the creation of “Internet moms” who rely on the Internet for parenting interactions. Using a mixed-methods design, this paper conducted participant observation and in-depth interviews with 90 mothers from various industries born after 1980/1990 across multiple geographies in China to examine the impact of urban women’s Internet practices on the psychology and practice of parenting during the COVID-19 pandemic, as well as how they were empowered by media technologies to practice motherhood and complete their role socialization through the sharing of parenting information, experiences, and actions. The purpose of this qualitative study was to investigate the changing impact of Internet-based parenting practices on Chinese urban women’s daily lives during the COVID-19 pandemic. Through the analysis of these influences, it was found that the whole society, including urban parenting groups, paid attention to self-expression and self-worth and further hoped to arouse society’s recognition, face up to the identity of “mother” and “female,” and give more attention and support to women. The study also found that, as interpersonal communication channels were hindered during the COVID-19 pandemic, the power of the Internet, represented by social media, has created a new platform for information empowerment, action mutual, and ideation of motherhood for urban women formerly bound to family and parenting matters. From individual, family, and individual parenting experiences to group, social, and shared scenarios, urban women are engaged in emotional and memory interactions, including motherhood-related expression, experiences, and collaboration. This shift from virtual to physical has reshaped their parenting view, helping them break through the confines of family experience and traditional customs in addition to providing psychological motivation to express their gender concepts, shape their self-image, construct gender power, and interpret intimate relationships, pushing them to become more reflective of the times, as well as more capable and authoritative.
The role of socioeconomic status in different trajectories of depressive symptoms in Chinese college freshmen
Authors: Liu Qingying , Tan Junying , Feng Zhengzhi , Tu Shen
Published: August 2022

The associations between socioeconomic status (SES) and depressive symptoms have been found in previous studies. However, the role of SES in different trajectories of depressive symptoms in Chinese college freshmen has not been discovered. The present study aims to identify how depressive symptom trajectories are related to SES during the first semester of freshman. Six hundred fifty-two Chinese college freshmen (64.9% female) were followed 4 times across 4 months. The Latent Growth Mixture Model (LGMM) was used to identify trajectories of depressive symptoms. Multinomial Logical Regression was used to identify the influence of family socioeconomic status (FSES), subjective socioeconomic status (SSS), and demographic variables on trajectories of depressive symptoms for freshmen. Results found that college freshmen’s depressive symptoms gradually decreased during the four tests, F(2.758, 1795.383) = 52.642, p < 0.001, and there are three trajectories of depressive symptoms: normal group (Class 1, 73.1%), depression risk group (Class 2, 20.7%), and depression deterioration group (Class 3, 6.1%). The decline of SSS predicted increasing depressive symptoms. Age and left-behind experience have significant effects on trajectories of depressive symptoms. FSES, birthplace, and gender had no significant impact on trajectories of depressive symptoms. These results demonstrated that low SSS, age, and left-behind might be risk factors for the development of depressive symptoms.
Role of politically motivated internet addiction and ideological passion in linking college student's mental health education and wellbeing
Authors: Meng Shuyu
Published: August 2022

College students are increasingly reporting common mental health issues like depression and anxiety, raising severe concerns for students' psychological wellbeing. Specifically, after the emergence of Post-COVID-19, digitization caused a potential role in mitigating students' psychological concerns. Therefore, the role of mental health education has been regarded as a topic of interest in managing the issue of Chinese college students' mental wellbeing. This study intends to look into the relationship between mental health education and psychological wellbeing, along with the moderating role of politically motivated internet addiction and the ideological passion of college students. For the given reason, the random sampling method was employed for collecting data from target respondents. The study uses 750 questionnaires prepared on a five-point Likert scale that were distributed to the respondents with an expected response rate of 50%. The partial least square (PLS) software was used to analyze the data for this study. The study concludes that there is a significant moderating role of politically motivated internet addiction and ideological passion in the relationship between college students' mental health and wellbeing. The study meaningfully contributes to the body of knowledge by establishing the unique, positive moderating role of Politically motivated internet addition in strengthening the relationship which undoubtedly will assist in improving the psychological wellbeing of college students through mental health education policies and implications.
Predictors of STD Screening From the Indigenist Stress-Coping Model Among Native Adults With Binge Substance Use
Authors: Magarati Maya , Chambers Rachel Strom , Yenokyan Gayane , Rosenstock Summer , Walls Melissa , Slimp Anna , Larzelere Francene , Lee Angelita , Pinal Laura , Tingey Lauren
Published: August 2022

Objective

The American Indian/Alaska Native (AI/AN) population in the U.S. is thriving in spite of settler colonialist efforts of erasure. AI/AN people, however, continue to experience persistent health disparities including a disproportionate burden of substance use and sexually transmitted diseases/infections (STDs/STIs), as well as a disproportionate lack of public health STD screening services and STD prevention interventions grounded in AI/AN social contexts, experiences, and epistemologies. The present study explored how stressors and protective factors based on the Indigenist Stress Coping framework predict STD screening outcomes among Native adults.

Methods

We analyzed baseline self-report data from 254 Native adults ages 18–55 years with recent binge substance use who were enrolled in an evaluation of “EMPWR,” a two-session STD risk reduction program in a rural, reservation-based community in the U.S. Southwest. Logistic regression models with robust variance were used to estimate odds ratios of lifetime STD testing for the theoretical stressors and cultural buffers.

Results

A little over half the sample were males (52.5%, n = 136), with a mean age of 33.6 years (SD = 8.8). The majority (76.7%, n = 195) reported having ever been screened for STD in their life. Discrimination score were significantly associated with lifetime STD testing: The higher discrimination was associated with lower odds of STD testing in the fully adjusted model (aOR = 0.40, 95%CI: 0.18, 0.92). The effects of AI/AN-specific cultural buffer such as participation in traditional practices on STD testing outcomes was in the expected positive direction, even though the association was not statistically significant. Household size was significantly associated with STD screening: The higher the number of people lived together in the house, the higher the odds of STD testing in the fully adjusted model (aOR = 1.19, 95%CI: 1.04, 1.38).

Conclusion

Our findings suggest that STD prevention programs should take into consideration AI/AN-specific historical traumatic stressors such as lifetime discrimination encounters and how these interact to drive or discourage sexual health services at local clinics. In addition, larger household size may be a protective factor functioning as a form of social support, and the extended family's role should be taken into consideration. Future research should consider improvement in measurements of AI/AN enculturation constructs.
Sex differences in comorbidities and COVID-19 mortality–Report from the real-world data
Authors: Yoshida Yilin , Wang Jia , Zu Yuanhao
Published: August 2022

Background

The differential effect of comorbidities on COVID-19 severe outcomes by sex has not been fully evaluated.

Objective

To examine the association of major comorbidities and COVID-19 mortality in men and women separately.

Methods

We performed a retrospective cohort analysis using a large electronic health record (EHR) database in the U.S. We included adult patients with a clinical diagnosis of COVID-19 who also had necessary information on demographics and comorbidities from January 1, 2016 to October 31, 2021. We defined comorbidities by the Charlson Comorbidity Index (CCI) using ICD-10 codes at or before the COVID-19 diagnosis. We conducted logistic regressions to compare the risk of death associated with comorbidities stratifying by sex.

Results

A total of 121,342 patients were included in the final analysis. We found significant sex differences in the association between comorbidities and COVID-19 death. Specifically, moderate/severe liver disease, dementia, metastatic solid tumor, and heart failure and the increased number of comorbidities appeared to confer a greater magnitude of mortality risk in women compared to men.

Conclusions

Our study suggests sex differences in the effect of comorbidities on COVID-19 mortality and highlights the importance of implementing sex-specific preventive or treatment approaches in patients with COVID-19.
Dynamic change of COVID-19 lung infection evaluated using co-registration of serial chest CT images
Authors: Chen Xiao , Zhang Yang , Cao Guoquan , Zhou Jiahuan , Lin Ya , Chen Boyang , Nie Ke , Fu Gangze , Su Min-Ying , Wang Meihao
Published: August 2022

Purpose

To evaluate the volumetric change of COVID-19 lesions in the lung of patients receiving serial CT imaging for monitoring the evolution of the disease and the response to treatment.

Materials and methods

A total of 48 patients, 28 males and 20 females, who were confirmed to have COVID-19 infection and received chest CT examination, were identified. The age range was 21–93 years old, with a mean of 54 ± 18 years. Of them, 33 patients received the first follow-up (F/U) scan, 29 patients received the second F/U scan, and 11 patients received the third F/U scan. The lesion region of interest (ROI) was manually outlined. A two-step registration method, first using the Affine alignment, followed by the non-rigid Demons algorithm, was developed to match the lung areas on the baseline and F/U images. The baseline lesion ROI was mapped to the F/U images using the obtained geometric transformation matrix, and the radiologist outlined the lesion ROI on F/U CT again.

Results

The median (interquartile range) lesion volume (cm3) was 30.9 (83.1) at baseline CT exam, 18.3 (43.9) at first F/U, 7.6 (18.9) at second F/U, and 0.6 (19.1) at third F/U, which showed a significant trend of decrease with time. The two-step registration could significantly decrease the mean squared error (MSE) between baseline and F/U images with p < 0.001. The method could match the lung areas and the large vessels inside the lung. When using the mapped baseline ROIs as references, the second-look ROI drawing showed a significantly increased volume, p < 0.05, presumably due to the consideration of all the infected areas at baseline.

Conclusion

The results suggest that the registration method can be applied to assist in the evaluation of longitudinal changes of COVID-19 lesions on chest CT.
Fear of COVID-19 among homeless individuals in Germany in mid-2021
Authors: Hajek André , Bertram Franziska , Rüth Victoria van , Dost Katharina , Graf Wiebke , Brenneke Anna , Kowalski Veronika , Püschel Klaus , Schüler Christine , Ondruschka Benjamin , Heinrich Fabian , König Hans-Helmut
Published: August 2022

Aims

To investigate the prevalence and the correlates of fear of COVID-19 among homeless individuals.

Methods

We used data from the “national survey on psychiatric and somatic health of homeless individuals during the COVID-19 pandemic” (NAPSHI-study) which took place in several large cities in Germany in Mid-2021 (n = 666 in the analytical sample). Mean age equaled 43.3 years (SD: 12.1 years), ranging from 18 to 80 years. Multiple linear regressions were performed.

Results

In our study, 70.9% of the homeless individuals reported no fear of COVID-19. Furthermore, 14.0% reported a little fear of COVID-19, 8.4% reported some fear of COVID-19 and 6.7% reported severe fear of COVID-19. Multiple linear regressions revealed that fear of COVID-19 was higher among individuals aged 50–64 years (compared to individuals aged 18–29 years: β = 0.28, p < 0.05), among individuals with a higher perceived own risk of contracting the coronavirus 1 day (β = 0.28, p < 0.001) as well as among individuals with a higher agreement that a diagnosis of the coronavirus would ruin his/her life (β = 0.15, p < 0.001).

Conclusions

Only a small proportion of homeless individuals reported fear of COVID-19 in mid-2021 in Germany. Such knowledge about the correlates of higher levels of fear of COVID-19 may be helpful for addressing certain risk groups (e.g., homeless individuals aged 50–64 years). In a further step, avoiding extraordinarily high levels of fear of COVID-19 may be beneficial to avoid irrational thinking and acting regarding COVID-19 in this group.
Content characteristics predict the putative authenticity of COVID-19 rumors
Authors: Zhao Jingyi , Fu Cun , Kang Xin
Published: August 2022

Rumors regarding COVID-19 have been prevalent on the Internet and affect the control of the COVID-19 pandemic. Using 1,296 COVID-19 rumors collected from an online platform (piyao.org.cn) in China, we found measurable differences in the content characteristics between true and false rumors. We revealed that the length of a rumor's headline is negatively related to the probability of a rumor being true [odds ratio (OR) = 0.37, 95% CI (0.30, 0.44)]. In contrast, the length of a rumor's statement is positively related to this probability [OR = 1.11, 95% CI (1.09, 1.13)]. In addition, we found that a rumor is more likely to be true if it contains concrete places [OR = 20.83, 95% CI (9.60, 48.98)] and it specifies the date or time of events [OR = 22.31, 95% CI (9.63, 57.92)]. The rumor is also likely to be true when it does not evoke positive or negative emotions [OR = 0.15, 95% CI (0.08, 0.29)] and does not include a call for action [OR = 0.06, 95% CI (0.02, 0.12)]. By contrast, the presence of source cues [OR = 0.64, 95% CI (0.31, 1.28)] and visuals [OR = 1.41, 95% CI (0.53, 3.73)] is related to this probability with limited significance. Our findings provide some clues for identifying COVID-19 rumors using their content characteristics.
Comparison of clinical outcomes and risk factors for COVID-19 infection in cancer patients without anticancer treatment and noncancer patients
Authors: Yang Sen , Zhao Huaxin , Cui Ran , Ma Le , Ge Xuhua , Fu Qiangqiang , Yu Dehua , Niu Xiaomin
Published: August 2022

Background

Previous studies have shown that cancer patients have higher rates of coronavirus disease 2019 (COVID-19) infection and mortality than noncancer patients. However, the differences between cancer patients undergoing regular follow-up without anticancer treatment and noncancer patients with COVID-19 have remained insufficiently investigated.

Methods

A retrospective case–control study of 52 patients with COVID-19 infection was performed with a 1:3 matched proportion of cancer patients undergoing regular follow-up without anticancer treatment and noncancer patients. The demographic characteristics, clinical data, laboratory tests, treatment, and complications of patients were collected from medical records. Chi-square tests and univariate and multivariate regressions were performed to assess the differences between these two cohorts of COVID-19 patients with and without cancer and risk factors for severe events in COVID-19 patients.

Results

Increased C-reactive protein (CRP) (>4 mg/L) (p = 0.015) and lactate dehydrogenase (LDH) (>243 IU/L) (p = 0.038) were identified as risk factors for severe events in all enrolled COVID-19 patients based on multivariate analysis, but cancer as a chronic disease (p = 1.000) was not identified as an independent risk factor for severe events in COVID-19 patients. Compared with noncancer patients, cancer patients had a significantly longer median hospitalization time (29 days vs. 19 days, p = 0.048) and a higher incidence of hypoalbuminemia complications (84.6 vs. 46.2%, p = 0.016).

Conclusions

Increased CRP and LDH were risk factors for severe events in all enrolled COVID-19 patients, and an increased incidence of hypoalbuminemia complications and longer hospitalization were noted in COVID-19 cancer patients undergoing regular follow-up without anticancer treatment compared with noncancer patients.
Effects of age, period, and cohort on the prevalence of frailty in Chinese older adults from 2002 to 2014
Authors: Li Siying , Fan Wenye , Zhu Boya , Ma Chao , Tan Xiaodong , Gu Yaohua
Published: August 2022

Background

Currently, longitudinal studies on frailty are in an early stage, particularly in low- and middle-income countries. Only one study was conducted in Hong Kong to examine age-period-cohort effects on the prevalence of frailty among Chinese older adults.

Objectives

This study aims to shed light on the prevalence trajectory of frailty among older adults in mainland China through the APC model and to analyze the effects of age, period, and cohort on the prevalence trajectory.

Methods

The sample for this study was older adults aged 65–109 years old from the 2002 to 2014 Chinese Longitudinal Healthy Longevity Survey (CLHLS). Frailty status was measured by Rockwood FI. An age-period-cohort model was used to describe the effects of age, period, and cohort on the prevalence trajectory of frailty.

Results

The prevalence of frailty among Chinese older adults changed significantly with age, period, and cohort. Furthermore, the effect of age was much stronger than the effect of period and cohort. The prevalence of frailty in the 101–103 and 104–106 age groups was 8.998 (95% CI 13.667–5.924) and 8.699 (95% CI 13.037–5.805) times higher than the in the 65–67 age group, respectively. The sensitivity analysis based on Fried's frailty phenotype showed similar results, confirming the robustness of our findings.

Conclusion

All of the age effect reflecting the individual aging process, period effect reflecting change in the social environment, and birth cohort effect reflecting different generations could influence the prevalence of frailty at the population level. In contrast, the age effect was the main effect.
Average evolution and size-topology relations for coarsening 2d dry foams
Authors: Chieco Anthony T. , Sethna James P. , Durian Douglas J.
Published: August 2022

Two-dimensional dry foams coarsen according to the von Neumann law as dA/dt ∝ (n − 6) where n is the number of sides of a bubble with area A. Such foams reach a self-similar scaling state where area and side-number distributions are stationary. Combining self-similarity with the von Neumann law, we derive time derivatives of moments of the bubble area distribution and a relation connecting area moments with averages of the side-number distribution that are weighted by powers of bubble area. To test these predictions, we collect and analyze high precision image data for a large number of bubbles squashed between parallel acrylic plates and allowed to coarsen into the self-similar scaling state. We find good agreement for moments ranging from 2–20.
“Damaged genitals”—Cut women's perceptions of the effect of female genital cutting on sexual function. A qualitative study from Sweden
Authors: Jordal Malin , Påfs Jessica , Wahlberg Anna , Johansen R. Elise B.
Published: August 2022

Female genital cutting (FGC) is a traditional practice, commonly underpinned by cultural values regarding female sexuality, that involves the cutting of women's external genitalia, often entailing the removal of clitoral tissue and/or closing the vaginal orifice. As control of female sexual libido is a common rationale for FGC, international concern has been raised regarding its potential negative effect on female sexuality. Most studies attempting to measure the impact of FGC on women's sexual function are quantitative and employ predefined questionnaires such as the Female Sexual Function Index (FSFI). However, these have not been validated for cut women, or for all FGC-practicing countries or communities; nor do they capture cut women's perceptions and experiences of their sexuality. We propose that the subjective nature of sexuality calls for a qualitative approach in which cut women's own voices and reflections are investigated. In this paper, we seek to unravel how FGC-affected women themselves reflect upon and perceive the possible connection between FGC and their sexual function and intimate relationships. The study has a qualitative design and is based on 44 individual interviews with 25 women seeking clitoral reconstruction in Sweden. Its findings demonstrate that the women largely perceived the physical aspects of FGC, including the removal of clitoral tissue, to affect women's (including their own) sexual function negatively. They also recognized the psychological aspects of FGC as further challenging their sex lives and intimate relationships. The women desired acknowledgment of the physical consequences of FGC and of their sexual difficulties as “real” and not merely “psychological blocks”.
Assessment of soil fertility status in cotton-based cropping systems in Cote d’Ivoire
Authors: Koné Ismail , Kouadio Konan-Kan Hippolyte , Kouadio Emmanuel N’Goran , Agyare Wilson Agyei , Owusu-Prempeh Nat , Amponsah William , Gaiser Thomas
Published: August 2022

Cotton is the main cash crop in northern Côte d’Ivoire, where intensive cultivation along with low external inputs has led to a decline in crop yields due to soil degradation. The present study aims to assess the evolution of soil fertility during the 2013 and 2021 periods in the cotton basin area of Côte d’Ivoire. More specifically, the study (i) identified the limiting physico-chemical parameters of soil fertility, and (ii) analysed the state of evolution of soil fertility in 2013 and 2021 in the cotton basin of Côte d’Ivoire. For this purpose, a total of 64 soil samples were taken in 2013 and in 2021 on the same cotton plots on the 0-20 cm horizon. Chemical analyses of the soil samples in the laboratory were carried out on the following parameters: particle size distribution, pH water, total nitrogen (NT), Potassium (K+), Calcium (Ca2+), Magnesium (Mg2+), Sodium (Na+) and Cation exchange capacity (CEC). The results of the soil analyses showed that the sandy-clay textured topsoils dominate the whole study area in both years. This leads to a low retention capacity of exchangeable bases. Determination of the soil pH showed that the pH varies from slightly acidic to neutral (6.5<pH<7). The most limiting chemical properties are Cation exchange capacity (CEC) and the sum of the exchangeable bases (SEB) in the department of Korogho, Boundiali, and Ferkessedougou and the most limiting chemical properties in the department of Mankono are CEC. However, during the period from 2013 to 2021 the content of exchangeable cations (Ca2+, Mg2+ and K+) and the base saturation (BS) increased significantly in all the departments, more precisely in the department of Mankono. Although we observed a slight increase in the chemical properties of the soils in 2021 compared to 2013, the values were still below the minimum required threshold. This result implies that the soils have poor physico-chemical properties and consequently a low level of fertility, which compromises the sustainability of the cotton production system. The application of organic and mineral amendments is therefore essential to increase the nutrient content of these soils.
Determination of an RT-qPCR viral load cutoff point for the etiologic diagnosis of rotavirus A diarrhea in neonate dairy calves
Authors: Caffarena Rubén D. , Castells Matías , Schild Carlos O. , Casaux María L. , Armendano Joaquín I. , Colina Rodney , Giannitti Federico
Published: August 2022

Rotavirus A (RVA) is amongst the most widespread causes of neonatal calf diarrhea. Because subclinical infections are common, the diagnosis of RVA-induced diarrhea cannot rely solely on molecular viral detection. However, RT-qPCR allows for quantification of RVA shedding in feces, which can be correlated with clinical disease. Here, we determine an optimal cutoff of rotaviral load quantified by RT-qPCR to predict RVA causality in diarrheic neonate calves, using RVA antigen-capture ELISA as reference test. Feces from 328 diarrheic (n = 175) and non-diarrheic (n = 153), <30-day-old dairy calves that had been tested by ELISA and tested positive by RT-qPCR were included. Of 82/328 (25.0%) ELISA-positive calves, 53/175 (30.3%) were diarrheic, whereas 124/153 (81.0%) non-diarrheic calves tested negative by ELISA. The median log10 viral load was significantly higher in diarrheic vs. non-diarrheic and ELISA-positive vs. -negative calves, indicating a higher viral load in diarrheic and ELISA-positive calves. A receiver operating characteristic (ROC) analysis was conducted using the viral loads of the 175 diarrheic calves that had tested either positive (n = 53, cases) or negative (n = 122, controls) by ELISA. The optimal log10 viral load cutoff that predicted RVA causality in diarrheic calves was 9.171. A bootstrapping procedure was performed to assess the out-of-bag performance of this cutoff point, resulting in sensitivity = 0.812, specificity = 0.886, area under the curve = 0.922, and positive and negative diagnostic likelihood ratios of 11.184 and 0.142, respectively. The diagnostic accuracy of the cutoff was excellent to outstanding. This information will help in the interpretation of RVA RT-qPCR results in feces of diarrheic calves submitted for laboratory testing.
Goat SNX29: mRNA expression, InDel and CNV detection, and their associations with litter size
Authors: Wang Qian , Bi Yi , Wang Zhiying , Zhu Haijing , Liu Mei , Wu Xianfeng , Pan Chuanying
Published: August 2022

The sorting nexin 29 (SNX29) gene, a member of the SNX family, is associated with material transport and lipid metabolism. Previous studies have shown that lipid metabolism affects reproductive function in animals. Thus, we hypothesized there is a correlation between the SNX29 gene and reproductive trait. To date, studies on the relationship between the SNX29 gene and reproductive traits are limited. Therefore, the purpose of this study was to examine the polymorphism in the SNX29 gene and its correlation with litter size. Herein, the mRNA expression levels of SNX29 were assayed in various goat tissue. Surprisingly, we found that SNX29 was highly expressed in the corpus luteum, large and small follicles. This result led us to suggest that the SNX29 gene has a critical role in reproduction. We further detected potential polymorphisms in Shaanbei white cashmere (SBWC) goats, including insertion/deletion (InDel, n = 2,057) and copy number variation (CNV, n = 1,402), which were related to fertility. The 17 bp deletion (n = 1004) and the 20 bp deletion (n = 1,053) within the SNX29 gene were discovered to be significantly associated with litter size (P < 0.05), and individuals the ID genotype of P1-Del-17 bp and the DD genotype of P2-Del-20bp had larger litter size. Additionally, the four CNV loci had significant correlations with litter size (P < 0.01) in our detected population. In CNV5, individuals with the median genotype were superior compared to those with loss or gain genotype in term of litter size, and in other three CNVs showed better reproductive trait in the gain genotype. Briefly, these findings suggest that SNX29 could be used as a candidate gene for litter size in goat breeding through marker-assisted selection (MAS).
Understanding the Role of Prosocial Behavior in Youth Mental Health: Findings from a Scoping Review
Authors: Hirani Saima , Ojukwu Emmanuela , Bandara Nilanga Aki
Published: August 2022

Background: Mental health during a person’s adolescence plays a key role in setting the stage for their mental health over the rest of their life. Hence, initiatives that promote adolescents’ wellbeing are an important public health goal. Helping others can take a variety of forms, and the literature suggests that helping others can positively impact a person’s wellbeing. However, there is a lack of data that synthesizes the impact of helping others on adolescents’ wellbeing. Therefore, this review aims to synthesize the available evidence related to helping others and to youth wellbeing. Methods: A scoping review search was undertaken with no date restrictions. CINAHL, Medline and PyschINFO, were searched for studies that analyzed the relationship between helping others and youth mental health. Results: Data from 213 papers were included in the scoping review. Three main themes were observed: (1) the relationship between helping others and mental health outcomes among youths (positive and negative); (2) factors associated with youth engagement in prosocial behavior (facilitators and barriers); (3) the impact of interventions related to helping others, and to youth mental health (positive and negative). Conclusions: An overwhelmingly positive relationship exists between youth prosocial behavior and its influence on youth mental health.
Agrochemicals—Shifting from the Past to the Future with a New Journal
Authors: Athanassiou Christos G.
Published: August 2022

Agrochemicals in Contemporary Agriculture [...]
EMM-LC Fusion: Enhanced Multimodal Fusion for Lung Cancer Classification
Authors: Barrett James , Viana Thiago
Published: August 2022

Lung cancer (LC) is the most common cause of cancer-related deaths in the UK due to delayed diagnosis. The existing literature establishes a variety of factors which contribute to this, including the misjudgement of anatomical structure by doctors and radiologists. This study set out to develop a solution which utilises multiple modalities in order to detect the presence of LC. A review of the existing literature established failings within methods to exploit rich intermediate feature representations, such that it can capture complex multimodal associations between heterogenous data sources. The methodological approach involved the development of a novel machine learning (ML) model to facilitate quantitative analysis. The proposed solution, named EMM-LC Fusion, extracts intermediate features from a pre-trained modified AlignedXception model and concatenates these with linearly inflated features of Clinical Data Elements (CDE). The implementation was evaluated and compared against existing literature using F1 score, average precision (AP), and area under curve (AUC) as metrics. The findings presented in this study show a statistically significant improvement (p < 0.05) upon the previous fusion method, with an increase in F-Score from 0.402 to 0.508. The significance of this establishes that the extraction of intermediate features produces a fertile environment for the detection of intermodal relationships for the task of LC classification. This research also provides an architecture to facilitate the future implementation of alternative biomarkers for lung cancer, one of the acknowledged limitations of this study.
Recognizing and Distinguishing the Phenomenon Referred to as Meningioma
Authors: Rothschild Bruce M.
Published: August 2022

Background: The reliability of a recent review of meningiomas in the archeologic record was difficult to assess, given the inverted sex ratio of the report and other contents apparently at variance with anatomical/medical findings in scientifically identified cases. It therefore seemed appropriate to reexamine the nature of meningiomas and derive improve criteria for their recognition in the archeologic record and distinguish them from hemangiomas and bone marrow hyperplasia (recognized in the form of porotic hyperostosis). Methods: Medically documented cases of meningiomas were examined to establish a macroscopic standard distinguishing them. Alleged cases in the archeologic record were examined for conformity with those criteria. Results: An en face pattern of uniform mesh with contained whorls appears pathognomonic for meningiomas. This contrasts with the non-uniform marrow expansion displacement of trabeculae in porotic hyperostosis and non-uniform vascular displacement of trabeculae in hemangiomas. Reassessment of past attributions revealed few cases of meningiomas that could be confidently diagnosed. Those identified have sex ratios parsimonious with medical literature reports. Conclusions: Criteria suggested for identifying meningiomas permit distinguishing from hemangiomas, bone marrow hyperplasia (porotic hyperostosis) and from the macroscopically observable surface spicules characteristic of osteosarcomas. Examination for fulfillment of criteria for meningiomas and hemangiomas seems to provide a picture (including sex ratios) mirroring that of the clinical literature, concluding that Cook and Danforth’s disparate ratios were related to less fastidious case selection. Additionally, confidence in recognizing porotic hyperostosis may be compromised because of apparent similar macroscopic alterations to those seen with hemangiomas.
Combination of Deep Cross-Stage Partial Network and Spatial Pyramid Pooling for Automatic Hand Detection
Authors: Dewi Christine , Juli Christanto Henoch
Published: August 2022

The human hand is involved in many computer vision tasks, such as hand posture estimation, hand movement identification, human activity analysis, and other similar tasks, in which hand detection is an important preprocessing step. It is still difficult to correctly recognize some hands in a cluttered environment because of the complex display variations of agile human hands and the fact that they have a wide range of motion. In this study, we provide a brief assessment of CNN-based object identification algorithms, specifically Densenet Yolo V2, Densenet Yolo V2 CSP, Densenet Yolo V2 CSP SPP, Resnet 50 Yolo V2, Resnet 50 CSP, Resnet 50 CSP SPP, Yolo V4 SPP, Yolo V4 CSP SPP, and Yolo V5. The advantages of CSP and SPP are thoroughly examined and described in detail in each algorithm. We show in our experiments that Yolo V4 CSP SPP provides the best level of precision available. The experimental results show that the CSP and SPP layers help improve the accuracy of CNN model testing performance. Our model leverages the advantages of CSP and SPP. Our proposed method Yolo V4 CSP SPP outperformed previous research results by an average of 8.88%, with an improvement from 87.6% to 96.48%.
Optimization of Oil Recovery from Japonica Luna Rice Bran by Supercritical Carbon Dioxide Applying Design of Experiments: Characterization of the Oil and Mass Transfer Modeling
Authors: Coelho José P. , Robalo Maria Paula , Fernandes Inês S. , Stateva Roumiana P.
Published: August 2022

This study presents an optimization strategy for recovery of oil from Japonica Luna rice bran using supercritical carbon dioxide (scCO2), based on design of experiments (DoE). Initially, a 24−1 two level fractional factorial design (FFD) was used, and pressure, temperature, and scCO2 flow rate were determined as the significant variables; while the yield, total flavonoids content (TFC), and total polyphenols content (TPC) were the response functions used to analyze the quality of the extracts recovered. Subsequently, central composite design (CCD) was applied to examine the effects of the significant variables on the responses and create quadratic surfaces that optimize the latter. The following values of pressure = 34.35 MPa, temperature = 339.5 K, and scCO2 flow rate = 1.8 × 10−3 kg/min were found to simultaneously optimize the yield (6.83%), TPC (61.28 μmol GAE/g ext), and TFC (1696.8 μmol EC/g ext). The fatty acid profile of the oils was characterized by GC-FID. It was demonstrated that the acids in largest quantities are C16:0 (15–16%), C18:1 (41%), and C18:2 (38–39%). Finally, three mass transfer models were applied to determine the mass transfer coefficients and assess the cumulative extraction curves, with an AAD% of 4.16, for the best model.
On-Surface Chemistry on Low-Reactive Surfaces
Authors: Geagea Elie , Palmino Frank , Cherioux Frédéric
Published: August 2022

Zero-dimensional (0D), mono-dimensional (1D), or two-dimensional (2D) nanostructures with well-defined properties fabricated directly on surfaces are of growing interest. The fabrication of covalently bound nanostructures on non-metallic surfaces is very promising in terms of applications, but the lack of surface assistance during their synthesis is still a challenge to achieving the fabrication of large-scale and defect-free nanostructures. We discuss the state-of-the-art approaches recently developed in order to provide covalently bounded nanoarchitectures on passivated metallic surfaces, semiconductors, and insulators.
Parental Knowledge of Appendicitis and Preference for Operative or Non-Operative Treatment at a United Kingdom Children’s Hospital
Authors: Monks Kitty , Hall Nigel J.
Published: August 2022

Appendicitis is a common cause of abdominal pain in children, and is the most common reason for children to undergo emergency abdominal surgery. To guide our research program in this field, we aimed to determine parental understanding with regard to appendicitis and its treatment. We also wished to assess parental preference for non-operative or surgical treatment of children with uncomplicated appendicitis. We asked parents attending a children’s outpatient clinic to complete a brief questionnaire that was interspersed with educational content to rectify any knowledge gaps. A total of 396 parents (of 414 approached) agreed to participate. There were gaps in parental knowledge, including not knowing where the appendix is located (one-third of respondents), not knowing what appendicitis is (40% of respondents), and underestimating the incidence of appendicitis. Parents typically overestimated the risks of complications and dying from both uncomplicated and complicated appendicitis. There was no influence of gender, age, or previous experience of appendicitis on these findings. When presented with the scenario of equal effectiveness of non-operative treatment and surgery for uncomplicated appendicitis, 59% of respondents expressed a preference for non-operative treatment over surgery, while 21% expressed a preference for surgery (20% expressed no preference). These findings are important for clinicians and researchers when discussing appendicitis and treatment options with families, and justify ongoing research into the comparative effectiveness of non-operative treatment and surgery.
Changes in Ventilatory Support Requirements of Spinal Muscular Atrophy (SMA) Patients Post Gene-Based Therapies
Authors: Panagiotou Panagiota , Kanaka-Gantenbein Christina , Kaditis Athanasios G.
Published: August 2022

Spinal muscular atrophy (SMA) is a genetic neuromuscular disease resulting in global muscular weakness and, frequently, in respiratory failure and premature death. Gene-based therapies like Nusinersen are now available for patients with SMA. The aim of this review was to assess in “real world” studies, whether novel treatments would have a positive impact on the mechanical ventilatory support requirements of SMA patients, already initiated on ventilatory support prior to treatment administration. A literature search was performed in Pubmed using multiple combinations of MESH terms and the snowball procedure. A total of 14 publications were discussed in this review. Considering all patients included in the published studies who were on ventilatory support and were treated with Nusinersen, 13/172 (7.5%) had reduced needs for ventilatory support, 1/172 (0.6%) did not need ventilation post-treatment, and 122/172 (70.9%) were maintained on the same ventilator settings. Moreover, 2/41 (4.9%) children who were offered gene therapy had no need for further ventilatory support and 12/41 (29.2%) had reduced requirements. In conclusion, available evidence suggests that among children with SMA, who are on mechanical respiratory support either noninvasively or via tracheostomy at the time of gene-based treatment, only a few will be weaned off the ventilator or have reduced ventilator needs per 24 h. Children will usually require the same level of support as before treatment.
Parental and Pediatricians’ Attitudes towards COVID-19 Vaccination for Children: Results from Nationwide Samples in Greece
Authors: Steletou Evangelia , Giannouchos Theodoros , Karatza Ageliki , Sinopidis Xenophon , Vervenioti Aggeliki , Souliotis Kyriakos , Dimitriou Gabriel , Gkentzi Despoina
Published: August 2022

Although many studies have examined factors associated with COVID-19 vaccination and healthcare professionals’ attitudes towards vaccines, less is known about parents’ and pediatricians’ attitudes towards COVID-19 vaccination for children. Using two cross-sectional surveys from November to December 2021 in Greece, we aimed to assess parental intention to vaccinate their 5 to 17 years old children against COVID-19 and to evaluate pediatricians’ attitudes towards children’s vaccination against COVID-19. Overall, 439 parents and 135 pediatricians participated. Of them, 240 (54.7%) intended to vaccinate their children against COVID-19. The most commonly reported reasons for non-intention were the short length of clinical trials and the fear of side effects. Only 16.6% of non-intenders would vaccinate their children if the pediatrician recommended it. The factors associated with higher intention to get vaccinated were a parent’s own vaccination against COVID-19, trust in official healthcare guidelines, increased trust in the state and the healthcare system during the pandemic, and older age. Of the pediatricians, 92.6% recommended children’s vaccination, and 75.6% agreed with mandating the vaccine. These findings suggest the need to tailor easy-to-understand messages by well-informed pediatricians to address safety concerns, educate, and clarify misconceptions through targeted interventions among those who currently do not wish to vaccinate their children.
Mental Health and Well-Being in Children
Authors: Nunes Cristina
Published: August 2022

Mental disorders are the largest cause of the burden of disease in the world [...]