bluuebunny/crossref_metadata_2025 huggingface dataset:
A retrospective study of arthroscopic treatment for patients with bordline developmental dysplasia of the hip
Authors: Gou Yu , Zhang Zi , Meng Binyang , Cao Jiangang , Zhu Jiawang , Li Hongzhou , Zhao Qian
Published: September 2024

Purpose

Hip arthroscopy is effective in treating bordline developmental dysplasia of the hip (BDDH), but there are only a few clinical reports in China, and its postoperative failure rate is still a problem that cannot be ignored. The aim of this study was to analyze the clinical effect of hip arthroscopy in BDDH treatment in China and to explore the risk factors influencing the efficacy of hip arthroscopy in BDDH treatment.

Methods

All of 22 cases of BDDH treated with arthroscopy in our hospital from November March 2017 to February 2022 were analyzed retrospectively, including ten males and 12 females, with an average age of 34.7 ± 9.5 years (19–53 years). All patients underwent arthroscopic treatment with acetabular plasty, labral repair, femoral osteoplasty, and capsular plication. Visual Analogue Scale (VAS), modified Harris Hip Scores (mHHS), Hip Outcome Score—activities of Daily Living (HOS-ADL) and International Hip Outcome Tool-12 (iHOT-12) were measured before operation and at the follow-up, and statistical analysis was performed. The Minimum clinically significant difference (MCID) and Patient Acceptable Symptom State (PASS) were also obtained.

Results

22 patients were followed up, and the follow-up time was ≥ one year, with an average of 21.4 ± 8.2 months. The VAS score decreased from 5.27 ± 1.58 points before surgery to 1.96 ± 0.92 points at the follow-up, and the difference was statistically significant (t = 9.05,P < 0.001). The mHHS score increased from 64.84 ± 13.58 points before surgery to 90.4 ± 10.11 points at the follow-up, and the difference was statistically significant (t=-7.07, P < 0.001). The HOS-ADL score increased from 68.92 ± 11.76 points before surgery to 88.91 ± 9.51 points at the follow-up, and the difference was statistically significant (t=-8.15,P < 0.001). The iHOT-12 score increased from 49.32 ± 12.01 points before surgery to 79.61 ± 15.89 points at the follow-up, and the difference was statistically significant (t=-7.66,P < 0.001). The MCID (mHHS) and MCID (HOS-ADL) were 81.8% and 77.3% respectively, and the PASS (mHHS) and PASS (HOS-ADL) were 86.4% and 72.7% respectively at the follow-up.

Conclusion

Hip arthroscopy can achieve good short-term outcomes in the treatment of BDDH.

Level of evidence

IV Therapeutic Study.
Shape matters: unsupervised exploration of IDH-wildtype glioma imaging survival predictors
Authors: Foltyn-Dumitru Martha , Mahmutoglu Mustafa Ahmed , Brugnara Gianluca , Kessler Tobias , Sahm Felix , Wick Wolfgang , Heiland Sabine , Bendszus Martin , Vollmuth Philipp , Schell Marianne
Published: September 2024

Objectives

This study examines clustering based on shape radiomic features and tumor volume to identify IDH-wildtype glioma phenotypes and assess their impact on overall survival (OS).

Materials and methods

This retrospective study included 436 consecutive patients diagnosed with IDH-wt glioma who underwent preoperative MR imaging. Alongside the total tumor volume, nine distinct shape radiomic features were extracted using the PyRadiomics framework. Different imaging phenotypes were identified using partition around medoids (PAM) clustering on the training dataset (348/436). The prognostic efficacy of these phenotypes in predicting OS was evaluated on the test dataset (88/436). External validation was performed using the public UCSF glioma dataset (n = 397). A decision-tree algorithm was employed to determine the relevance of features associated with cluster affiliation.

Results

PAM clustering identified two clusters in the training dataset: Cluster 1 (n = 233) had a higher proportion of patients with higher sphericity and elongation, while Cluster 2 (n = 115) had a higher proportion of patients with higher maximum 3D diameter, surface area, axis lengths, and tumor volume (p < 0.001 for each). OS differed significantly between clusters: Cluster 1 showed a median OS of 23.8 compared to 11.4 months of Cluster 2 in the holdout test dataset (p = 0.002). Multivariate Cox regression showed improved performance with cluster affiliation over clinical data alone (C index 0.67 vs 0.59, p = 0.003). Cluster-based models outperformed the models with tumor volume alone (evidence ratio: 5.16–5.37).

Conclusion

Data-driven clustering reveals imaging phenotypes, highlighting the improved prognostic power of combining shape-radiomics with tumor volume, thereby outperforming predictions based on tumor volume alone in high-grade glioma survival outcomes.

Clinical relevance statement

Shape-radiomics and volume-based cluster analyses of preoperative MRI scans can reveal imaging phenotypes that improve the prediction of OS in patients with IDH-wild type gliomas, outperforming currently known models based on tumor size alone or clinical parameters.

Key Points

Shape radiomics and tumor volume clustering in IDH-wildtype gliomas are investigated for enhanced prognostic accuracy.

Two distinct phenotypic clusters were identified with different median OSs.

Integrating shape radiomics and volume-based clustering enhances OS prediction in IDH-wildtype glioma patients.
Physiological Age of Stock Plants Determines Phytohormonal Changes in Leafy Cuttings of Prunus subhirtella 'Autumnalis'
Authors: Kunc Petra , Medič Aljaž , Hudina Metka , Veberič Robert , Osterc Gregor
Published: September 2024

The aim of this study was to investigate adventitious root formation in cuttings obtained from physiologically different old stock material. The ornamental cherry Prunus subhirtella ´Autumnalis´ was used for the experiment. We examined three stock plants, namely a physiologically mature stock plant (about 60 years old) and physiologically juvenile plants (21 years old), which were previously propagated by cuttings, semi-mature stock material and in vitro juvenile stock material. We also investigated the role of phytohormones in the induction phase of adventitious root (AR) formation depending on the physiological age of the stock plant and the time after cutting. High performance liquid chromatography coupled with mass spectrometry (HPLC–MS/MS) was used to identify and quantify the phytohormones. The difference in rooting and quality of the developed AR is observed between semi-mature stock and mature stock material. Cuttings from semi-mature plants rooted in 95.00% of cases, while cuttings from mature stock plants only rooted in 68.33%. The high concentration of strigolactones and jasmonic acid (JA) immediately after severance had an inhibitory effect on the development of adventitious roots, especially in cuttings of mature origin. The development of AR is positively influenced by the increase in indole-3-acetic acid (IAA) 4 h after cutting from the stock plant. Our results show that the formation of adventitious root formation depends on the concentration and ratio between different phytohormones.
Multiphase distribution in partly saturated hierarchical nonwoven fibre networks under applied load using X-ray computed tomography
Authors: Wegele Patrick , Rosén Tomas , Söderberg Daniel
Published: September 2024

In many industrial applications, nonwoven fibre networks are facilitated to operate under partly saturated conditions, allowing for filtration, liquid absorption and liquid transport. Resolving the governing liquid distribution in loaded polyamide-6 (PA6) fibre networks using X-ray computed micro-tomography is a challenge due to the similar X-ray attenuation coefficients of water and PA6 and limitations in using background subtraction techniques if the network is deformed, which will be the case if subjected to compression. In this work, we developed a method using a potassium iodide solution in water to enhance the liquid’s attenuation coefficient without modifying the water’s rheological properties. Therefore, we studied the evolving liquid distribution in loaded and partly saturated PA6 fibre networks on the microscale. Increasing the external load applied to the network, we observed an exponential decrease in air content while the liquid content was constant, increasing the overall saturation with increasing network strain. Furthermore, the microstructural properties created by the punch-needle process in the manufacturing of the network significantly influenced the out-of-plane liquid distribution. The method has been proven helpful in understanding the results of adaptions in both the fibre network design and manufacturing process, allowing for investigating the resulting liquid distribution on a microscale.
Correction potential and outcome of various surgical procedures for hallux valgus surgery: a living systematic review and meta-analysis
Authors: Ettinger S. , Spindler F. T. , Savli M. ,   D.A.F. Scientific Committee, Stukenborg-Colsman Christina , Ochman Sabine , Rammelt Stefan , Polzer Hans , Gutteck Natalia , Harrasser Norbert , Plaaß Christian , Baumbach Sebastian F.
Published: September 2024

Introduction

More than 100 surgical techniques are described for hallux valgus (HV) correction, but the most appropriate technique remains debatable. The aim of this study was to develop and conduct a “living systematic review” for the outcome of surgically treated HV.

Materials and methods

The “living systematic review” was conducted per the PRISMA-P and PICOS guidelines and is the basis for the German AWMF S2e guideline “Hallux valgus” (033-018). Four common databases and the grey-literature were searched. Eligible were studies on adult patients comparing either two different primary surgical interventions or the same primary surgical intervention for different hallux valgus severities. The main outcome parameters were the osseous correction potential and the patient rated outcome.

Results

Out of 3022 studies, 46 studies (100 arms) were included. The meta-analysis included 31 studies (53 arms). The IMA (1933 procedures) improved on average by 7.3°, without significant group differences. The HVA (1883 procedures) improved on average by 18.9°, with significantly better results for third generation MIS (21.2°). The AOFAS (1338 procedures) improved on average by 33.8 points without significant group differences. The meta-regression revealed constant AOFAS scores over time. 69%/39% of the correction potential for the IMA/HVA could be explained by the preoperative values and 82% of the AOFAS improvement by the preoperative AOFAS scores.

Conclusion

Open and minimally invasive techniques are powerful tools to correct hallux valgus deformity. Third generation MIS procedures revealed a possible superiority for the correction of the HVA. The AOFAS improvement appeared to be constant over time.

Level of evidence

Level I; living systematic review and meta-analysis of prospective comparative studies (level II) and randomized controlled trials (level I).
Effects of minute oscillation stretching training on muscle and tendon stiffness and walking capability in people with type 2 diabetes
Authors: Magris Riccardo , Monte Andrea , Nardello Francesca , Trinchi Michele , Vigolo Nicolò , Negri Carlo , Moghetti Paolo , Zamparo Paola
Published: September 2024

Aim

we investigated the effects of a 10 week training program (i.e., minute oscillatory stretching; MOS) on the mechanical responses and walking capability in people with type 2 diabetes (T2D).

Methods

seventeen T2D patients performed maximum voluntary contractions of the plantar flexor muscles during which Achilles tendon stiffness (kT) and muscle–tendon stiffness (kM) were evaluated at different percentages of the maximum voluntary force (MVC). In addition, each participant was requested to walk at different walking speeds (i.e. 2, 3, 4, 5, and 6 kmh−1) while their net energy cost of walking (Cnet), cumulative EMG activity per distance travelled (CMAPD) and kinematic parameters (step length, step frequency, the ankle/knee range of motion) were evaluated.

Results

maximum tendon elongation increased after MOS training, and kT significantly decreased (between 0 and 20% of MVC). No differences were observed for muscle elongation or kM after training. Cnet decreased after training (at the slowest tested speeds) while no changes in CMAPD were observed. Step length and ankle ROM during walking increased after training at the slowest tested speeds, while step frequency decreased; no significant effects were observed for knee ROM.

Conclusion

these results indicate the effectiveness of 10 weeks of MOS training in reducing tendon stiffness and the energy cost during walking in people with T2D. This training protocol requires no specific instrumentation, can be easily performed at home, and has a high adherence (92 ± 9%). It could, thus, be useful to mitigate mechanical tendon deterioration and improve physical behaviour in this population.
Extra-abdominal and intra-abdominal FET::CREM fusion mesenchymal neoplasms: comparative clinicopathological study of 9 new cases further supporting a distinct potentially aggressive sarcoma and report of novel sites
Authors: Agaimy Abbas , Blakely Morgan , Breimer Gerben E. , Hölsken Annett , Koppes Sjors A. , Meidenbauer Norbert , Rijken Johannes A. , Schad Arno , Simon Adrian G. , Stoehr Robert , Bishop Justin A. , Din Nasir Ud
Published: September 2024

With the wide use of RNA sequencing technologies, the family of FET::CREB fusion mesenchymal neoplasms has expanded rapidly to include potentially aggressive neoplasms, not fitting any well established WHO entity. Recently, a group of intra-abdominal FET(EWSR1/FUS)::CREB(CREM/ATF1) fused unclassified neoplasms has been reported followed by recent recognition of an analogous extra-abdominal category of unclassified neoplasms carrying EWSR1::ATF1 fusions. We describe 9 additional tumors (5 extra-abdominal and 4 abdominal) carrying an EWSR1::CREM (n = 8) and FUS::CREM (n = 1) fusion. Patients were 7 females and 2 males aged 10 to 75 years (median, 34). Extra-abdominal tumors originated in the head and neck (2 sinonasal, 1 orbital) and soft tissues (1 gluteal, 1 inguinal). Abdominal tumors involved stomach (2), mesentery (1), and kidney (1). Tumor size ranged from 3.5 to 11 cm (median, 6). Treatment was radical surgery with (5) or without (2) neo/adjuvant radio/chemotherapy. Extended follow-up of 5 patients (21–52 months; median, 24) showed an aggressive course in two (40%); one died of disseminated metastases 52 months after several intensified chemotherapy regimens, and one was alive with progressive abdominal disease at 21 months. The immunophenotype of the two subcohorts was significantly overlapping with variable expression of EMA (7 of 8), keratin AE1/AE3 (5 of 9), CD99 (4 of 7), MUC4 (2 of 8), ALK (3 of 8), synaptophysin (3 of 9), chromogranin (1 of 8), CD34 (3 of 6), CD30 (1 of 6), PAX8 (1 of 7), and inhibin (1 of 7), but no reactivity with desmin (0 of 8), S100 (0 of 8), and SOX10 (0 of 8). This series further solidifies the notion that FET::CREB fusions are not limited to the triad of angiomatoid fibrous histiocytoma, clear cell sarcoma, and malignant gastrointestinal neuroectodermal tumor, but characterize an emerging family of potentially aggressive neoplasms occurring at both intra- and extra-abdominal sites. These tumors underscore the promiscuity of the FET::CREB fusions and highlight the pivotal role of phenotype-oriented classification of these neoplasms that share the same genotype, still featuring significant biological and behavioral distinctness.
Mechanisms determining the multi-diversity of carrion visiting species along a gradient of carrion body mass
Authors: Wierer Amelie , von Hoermann Christian , Benbow M. Eric , Büchner Christiane , Feldhaar Heike , Fiderer Christian , Mitesser Oliver , Rietz Janine , Schlüter Jens , Zeitzler Johannes , Lackner Tomáš , Bässler Claus , Heurich Marco , Müller Jörg
Published: September 2024

Resource availability and habitat heterogeneity are essential drivers of biodiversity, but their individual roles often remain unclear since both factors are often correlated. Here, we tested the more-individuals hypothesis (MIH) and the habitat-heterogeneity hypothesis (HHH) for bacteria, fungi, dipterans, coleopterans, birds, and mammals on 100 experimentally exposed carcasses ranging by three orders of magnitude in body mass. At the level of each carcass we found marginal or significant support for the MIH for bacteria, fungi, and beetles in spring and significant support for fungi, dipterans, and mammals in summer. The HHH was supported only for bacteria in spring, while it was supported for all groups except mammals in summer. Overall multidiversity always increased with body mass, with a steeper increase in summer. Abundance based rarefaction-extrapolation curves for three classes of body mass showed the highest species richness for medium-sized carcasses, particular for dipterans and microbes, supporting the HHH also among carcasses. These findings complement existing necromass studies of deadwood, showing there are more niches associated with larger resource amounts and an increasing habitat heterogeneity between carcasses most pronounced for medium-sized species. Higher resource amount led to increased diversity of carrion-consuming organisms in summer, particularly due to the increasing number of niches with increasing size. Our findings underline the importance of distributed large carrion as well as medium-sized carrion in ecosystems supporting overall biodiversity of carrion-consumers. Furthermore, the different responses in spring and summer may inform strategies of carrion enrichment management schemes throughout the year.
Value assignment and uncertainty evaluation for certified reference gas mixtures
Authors: Cecelski Christina E. , Carney Jennifer , Possolo Antonio
Published: September 2024

The procedures used to assign values to certified reference gas mixtures and to evaluate their associated uncertainties, which are described in ISO 6143, and that were variously improved by Guenther and Possolo (Anal Bioanal Chem 399:489–500, 2011. 10.1007/s00216-010-4379-z), are further enhanced by the following developments: (i) evaluating and propagating uncertainty contributions derived from comparisons with historical reference gas mixtures of similar nominal composition; (ii) recognizing and quantifying mutual inconsistency (dark uncertainty) between primary standard gas mixtures used for calibration; (iii) employing Bayesian procedures for calibration, value assignment, and uncertainty evaluations; and (iv) employing state-of-the-art methods of meta-analysis to combine cylinder-specific measurement results. These developments are illustrated in examples of certification of two gas mixture Standard Reference Materials developed by the National Institute of Standards and Technology (NIST, USA). These examples serve only to demonstrate the methods described in this contribution and do not replace any official measurement results delivered in the certificates of any reference materials developed by NIST.
The Versatility of the Dicyanamide Anion (Dca) as a Bridging Ligand: Synthesis, Structure and Theory of a Unique Ladder Chain Consisting of 2 µ1,5-dca Bridged Dinuclear Cu2(dca)2 Units with Additional µ1,3-dca Bridges Along the Chain
Authors: Saadallah Yaakoub , Setifi Zouaoui , Ferjani Hela , Glidewell Christopher , Jelsch Christian , Setifi Fatima , Gil Diego M. , Echeverria Jorge , Reedijk Jan
Published: September 2024

The synthesis and structural details of a mixed-ligand Cu(II) coordination compound, specifically catena-poly[bis(dicyanamido)(1,10-phenanthroline-5,6-dione)copper(II)] 1, are reported. The title compound was synthesized utilizing a solvothermal method by employing dicyanamide, 1,10-phenanthroline-5,6-dione (phendione) and copper(II) sulfate pentahydrate (CuSO4•5H2O) as the starting materials. The title compound was characterized by standard analytical and spectroscopic methods. The 3D structure was determined by single-crystal X-ray diffraction. Examination of the supramolecular interaction patterns indicates that the stability of the ladder structure is achieved by the bridging dca anions and the presence of weak hydrogen-bonding contacts, specifically C-H···O and C-H···N bonds, as well as C-O/N···π interactions. These interactions together contribute to the formation of a ladder-type infinite chain structure. The generated structure has been theoretically investigated with Hirshfeld surface analysis, QTAIM and NCI analysis to reveal the interaction energies and bonds present inside and between molecules. The non-covalent interactions present in the crystal structure were further investigated theoretically, with particular attention to the cooperative C ≡ N···π(py) and N···π(hole) interactions involving the dicyanamide ligand and nitrile moieties in the compound. The solid-state stability of compound 1 appears to be strongly influenced by the cooperative effect of H-bonding interactions as well as the C ≡ N···π(py) and N···π(hole) contacts, as confirmed by theoretical calculations.

Graphical Abstract

Synthesis, Structure and Theoretical Calculations of a Unique Ladder Chain Containing the Dicyanamido Ligand (dca), Consisting of 2 µ1,5-dca Bridged Dinuclear Cu2(dca)2Units and Having µ1,3-dca Bridges along the Chain.

One sentence essence:

catena-poly[bis(dicyanamido)(1,10-phenanthroline-5,6-dione)copper(II)] is a unique ribbon ladder, infinite chain structure with two differently bridged dicyanamide anions
Planetary radio interferometry and Doppler experiment as an operational component of the Jupiter Icy Moons Explorer mission
Authors: Pallichadath Vidhya , Dirkx Dominic , Fayolle Marie S. , Frey Sándor , Gurvits Leonid I. , Boven Paul , Cimò Giuseppe , Fogasy Judit , Molera Calvés Guifré , Perger Krisztina , Said N. Masdiana Md , Vermeersen Bert L. A.
Published: September 2024

We present an overview of the operations and engineering interface for Planetary Radio Interferometry and Doppler Experiment (PRIDE) radio astronomy observations as a scientific component of the ESA’s Jupiter Icy Moons Explorer (JUICE) mission, as well as other prospective planetary and space science missions. The article discusses advanced scheduling and planning methods that make it possible to create observing schedules for observations of specific spacecraft in concurrence with observations of natural radio sources. In order to put this into practice and find suitable natural background calibrator sources for PRIDE of JUICE mission, we developed planning and scheduling software. The conventional scheduling software for natural celestial radio sources is not set up to include spacecraft as observation targets in the necessary control files. Therefore, difficulties already arise during observation planning. We report on the development of new and the adaptation of existing routines used in astrophysical and geodetic VLBI for satellite scheduling and planning. The analysis of the PRIDE science observations led to improved observational planning, and the mission’s scheduling methodologies were studied using a systems engineering approach. In addition, we highlighted the new procedures, like finding charts for selecting calibrator radio sources over a range of frequency bands and the outcomes of those strategies for science operation planning. A simulation of the flyby of Venus during the cruise phase of the JUICE spacecraft, based on the Tudat software, is also presented, resulting in a promising opportunity to test PRIDE techniques and evaluate the improvements that PRIDE observables can make to natural bodies’ ephemerides. The first $$\hbox {K}_{a}$$

K
a

-band (32 GHz) observations of the ESA’s BepiColombo by a radio telescope in the VLBI network, which employs a similar radio communications system as JUICE, were also demonstrated as a test case. The primary objective of these activities is to serve as a practice run for the upcoming operational PRIDE JUICE operations. We showcase the capabilities of the planning and scheduling software for other space missions.
Potential of complex microbial community in aerobic granular sludge as a bio-startup approach for next-generation wastewater treatment
Authors: Al-Gheethi Adel , Noman Efaq Ali , Alsahari Mohammed , Al-Maqtari Qais , Vo Dai-Viet N.
Published: September 2024

Activated sludge has a high diversity of infectious agents. However, many of these microorganisms contribute greatly to the biological treatment process due to the enzyme production and capability for degrading a wide range of organic compounds in wastewater. The present review discusses the potential of aerobic granular sludge as a bio-startup (AGS-BS-up) for new wastewater treatment plants. The complex microbial community in activated sludge was investigated using 16S metagenomic analysis. The potential of aerobic granular sludge prepared from activated sludge to be used as a bio-starting medium for food wastewater treatment plants (FWWTP) was discussed. AGS-BS-up appears to have high applicability to enhance the biological treatment of food wastewater (FWW). The hypothesis behind using aerobic granular sludge as a bio-startup for FWWTP lies in the high microbial biodiversity in the aerobic granular sludge, which contributes effectively to the biological treatment of food wastewater. Based on the previous studies, the AGS-BS-up is efficient in improving the quality of FWW to meet international standards required for safe disposal into the environment.
All Optic-Fiber Waveguide-Coupled SPR Sensor for CRP Sensing Based on Dielectric Layer and Poly-Dopamine
Authors: Ma Jinying , Li Shixin , Huang Xiangdong , Jiang Junfeng , Xu Tianhua , Liu Tiegen
Published: September 2024

We developed an all optic-fiber waveguide-coupled surface plasmon resonance (SPR) sensor using zirconium disulfide (ZrS2) and poly-dopamine (PDA) as the dielectric layer and biological cross-linker, respectively. This sensor can be employed to monitor the entire process of the C-reactive protein (CRP) sensing, including antibody modification and antigen detection. The design and the optimization of the optical fiber waveguide-coupled SPR sensor were realized, based on the transfer matrix method and first-principles calculations. The sensor was fabricated and characterized according to the optimized parameters. The experimental setup was implemented to measure the entire process of antibody modification and antigen detection for CRP with the detection limit of 3.21 pmol·mL−1, and the specificity tests were also carried out.
Classification of 2-term $$L_\infty $$-algebras
Authors: van Helden Kevin
Published: September 2024

We classify all 2-term $$L_\infty $$

L
∞

-algebras up to isomorphism. We show that such $$L_\infty $$

L
∞

-algebras are classified by a Lie algebra, a vector space, a representation (all up to isomorphism) and a cohomology class of the corresponding Lie algebra cohomology.
Experimental and Numerical Investigation on Attitude Adjustment Characteristics of Spacecraft with Impulse Thruster
Authors: Su Dongjian , Tao Ruyi , Wang Hao , Jiang Chunlei
Published: September 2024

The spacecraft serves as an effective tool for the space exploration. The present study is devoted to investigate the yaw attitude adjustment motion of the spacecraft influenced by the reaction-jet control system. A novel spacecraft device with impulse thrusters is designed for the vacuum test. And a synchronous test system, equipped with high-speed cameras, is established to record the motion process of the spacecraft under the various initial setting conditions. Subsequently, a six degrees of the freedom exterior ballistic model is calculated considering the interior ballistic process in the impulse thruster. The experimental results confirm that the position change of the designed device’s center of mass aligns with expectation, and the prediction error of final attitude angle remains below 2%. Based on this foundation, the change rule of the impulse thrust under different main charge loads is explored. The non-linear impulse thrust needs to be coupled with the rotation motion to enhance calculation accuracy. And the position of the center of mass is investigated to illustrate the advantage of the designed spacecraft structure. Finally, the calculation of the ignition interval time required for each target attitude angle is conducted, providing the essential data for further optimization design research. The outcomes from this paper can offer valuable technical means for advancing studies on the spacecraft attitude control.
Understanding the Variety of Domain Models: Views, Programs, Animations, and Other Models
Authors: Proper Henderik A. , Guizzardi Giancarlo
Published: September 2024

Humanity has long since used models, in different shapes and forms, to understand, redesign, communicate about, and shape, the world around us; including many different social, economic, biological, chemical, physical, and digital aspects. This has resulted in a wide range of modeling practices. When the models as used in such modeling practices have a key role to play in the activities in which these practices are ‘embedded’, the need emerges to consider the effectiveness and efficiency of such processes, and speak about modeling capabilities. In the latter situation, it also becomes relevant to develop a thorough understanding of the artifacts involved in modeling practices/capabilities. One context in which models play (an increasingly) important role is model-driven systems development, including software engineering, information systems engineering, business process engineering, enterprise engineering, and enterprise architecture management. In such a context, we come across a rich variety of modeling related artifacts, such as views, diagrams, programs, animations, specifications, etc. In this paper, which is actually part of an ongoing ‘journey’ in which we aim to gain deeper insights into the foundations of modeling, we take a fundamental look at the variety of modeling related artifacts as used in the context of model-driven (systems) development, while also presenting an associated framework for understanding, synthesizing the insights we obtained during the ‘journey’ so-far. In doing so, we will also argue that the aforementioned artifacts are actually specific kinds of models, albeit for fundamentally different purposes. The provided framework for understanding involves definitions of domain model, the Return on Modeling Effort (RoME), the conceptual fidelity of domain models, as well as views as a mechanism to manage the complexity of domain models.
Sustainable decision-making approach for operational excellence considering emerging technologies and energy sources: a review
Authors: Tripathi Varun , Reddy R. Meenakshi , Bhadauria Alok , Bandhu Din , Prashanth K. S. , Saxena Kuldeep K.
Published: September 2024

The cleaner operation system is a necessity of the current industrial scenario, and it depends on the operational performances and conditions. The recent advancement in decision-making approaches shows interest in a digitized perspective for monitoring operations planning and energy scheduling. However, the manufacturers are approaching a sustainable decision-making approach with hybrid energy systems for achieving operational excellence. A sustainable decision-making approach helps industry personnel in deploying the correct action planning for controlling operations efficiently and the hybrid energy system provides alternative power sources for operation without interruption. This paper discusses the sustainable decision-making approach used for achieving operational excellence considering energy sources. The present study shows concise details on the approaches used for improving operational excellence in different industrial sectors. The present study showed that the manufacturers succeed in operations outcomes by maximizing resources and energy utilization through innovative technologies.
A numerical study of volcanic ash ingestion and erosion of the front components of a high bypass turbofan engine
Authors: Ghenaiet A.
Published: September 2024

Airborne particles, such as dust and volcanic ash, pose a serious hazard to aircraft in flight due to their potential to cause erosion damage to engine components. It is crucial to anticipate and address the impact of erosion wear on engine performance and safety. This study aims to enhance our understanding of how volcanic ash particles behave when ingested through a high bypass turbofan engine (HBTFE) and assess the development of erosion wear in the front components. The effects of four different ash samples are assessed in various scenarios of encountering volcanic ash during cruise flight conditions. First, the flow solution is obtained for all front components, including the Pitot intake, spinner, fan, inlet guide vanes (IGVs), outlet guide vanes (OGVs), and connecting ducts. Based on the flow data, the particle motion equations are solved step by step using an in-house trajectory and erosion code. This latter adopts the Lagrangian approach, which incorporates a particle-eddy interaction model and includes probabilistic descriptions for the release positions of particles, sizes, and restitution factors. The finite element method (FEM) is used to track particles through the computational cells and determine impact positions and conditions. As a result, the Pitot intake design seems to prevent many ash particles from reaching the fan blade beyond 80% of the span. The fan blade leading edge (LE) exhibits extreme erosion on both sides. The blade’s pressure side (PS) displays erosion spreading practically on the entirety of the surface, especially near the trailing edge (TE). In contrast, the suction side (SS) has scattered erosion at lower rates. Furthermore, the rotor’s hub presents almost uniform erosion patterns, whereas the shroud depicts scattered erosion. This large fan appears to function as a separator, expelling a significant amount of ash particles through the secondary duct, thereby reducing the engine core’s susceptibility to erosion. Out of the four volcanic ash samples, those from the Kelud and Etna volcanoes appear to cause the highest hourly eroded mass, about twice as much as the samples from the Chaiten and Eyjafjallajokull volcanoes.
Impact of correlation between interest rates and mortality rates on the valuation of various life insurance products
Authors: Deelstra Griselda , Devolder Pierre , Roelants du Vivier Benjamin
Published: September 2024

In this paper, we question the traditional independence assumption between mortality risk and financial risk and model the correlation between these two risks, estimating its impact on the price of different life insurance products. The interest rate and the mortality intensity are modelled as two correlated Hull and White models in an affine set-up. We introduce two building blocks, namely the zero-coupon survival bond and the mortality density, calculate them in closed form and perform an investigation about their dependence on the correlation between mortality and financial risk, both with theoretical results and numerical analysis. We study the impact of correlation also for more structured insurance products, such as pure endowment, annuity, term insurance, whole life insurance and mixed endowment. We show that in some cases, the inclusion of correlation can lead to a severe underestimation or overestimation of the best estimate. Finally, we illustrate that the results obtained using a traditional affine diffusive set-up can be generalised to affine jump diffusion by computing the price of the zero-coupon survival bond in the presence of jumps.
Social and ecological determinants of antimicrobial resistance in Africa: a systematic review of epidemiological evidence
Authors: Bennett Catherine , Russel Will , Upton Rebecca , Frey Frank , Taye Bineyam
Published: September 2024

Background:

Antimicrobial resistance (AMR) is one of the greatest global health problems for humans, animals, and the environment. Although the association between various factors and AMR is being increasingly researched, the need to understand the contribution of social and ecological determinants, especially in developing nations, remains. This review fills these knowledge gaps by synthesizing existing evidence on the social and ecological determinants of AMR in Africa.

Results:

Twenty-four studies were selected based on predefined criteria from PubMed. 58.33% (n = 14) and 29.17% (n = 7) of the studies reported on ecological and social determinants of AMR, respectively, and 3 (12.5%) studies documented both social and environmental determinants of AMR. Sociodemographic factors include increased household size, poor knowledge, attitudes toward AMR, low educational levels, and rural residences. Indicators of poor water sanitation and hygiene, framing practices, and consumption of farm products were among the common ecological determinants of AMR and AM misuse in Africa.

Conclusion:

Our review demonstrates the importance of social and ecological determinants of AMR among African populations. The findings may be valuable to researchers, policymakers, clinicians, and those working in lower-income countries to implement AMR prevention programs utilizing a holistic approach.
Subshifts of finite symbolic rank
Authors: GAO SU , LI RUIWEN
Published: September 2024

The definition of subshifts of finite symbolic rank is motivated by the finite rank measure-preserving transformations which have been extensively studied in ergodic theory. In this paper, we study subshifts of finite symbolic rank as essentially minimal Cantor systems. We show that minimal subshifts of finite symbolic rank have finite topological rank, and conversely, every minimal Cantor system of finite topological rank is either an odometer or conjugate to a minimal subshift of finite symbolic rank. We characterize the class of all minimal Cantor systems conjugate to a rank-
$1$
subshift and show that it is dense but not generic in the Polish space of all minimal Cantor systems. Within some different Polish coding spaces of subshifts, we also show that the rank-1 subshifts are dense but not generic. Finally, we study topological factors of minimal subshifts of finite symbolic rank. We show that every infinite odometer and every irrational rotation is the maximal equicontinuous factor of a minimal subshift of symbolic rank
$2$
, and that a subshift factor of a minimal subshift of finite symbolic rank has finite symbolic rank.
On the edges of extinction: Indigenous whaling governance, the 1977 “bowhead controversy” and its legacy
Authors: Åman Sonja
Published: September 2024

In its nearly 80-year history, the International Whaling Commission (IWC) has shifted from a “whalers club” to an international governance body chiefly focused on the protection and conservation of global cetacean populations. Drawing on recent scholarship on extinction and its entanglements, this article compares two addresses given by whalers at IWC meetings 40 years apart to problematise the way whaling and its relation to extinction is conceptualised in international environmental governance. Guided by practice-oriented document analysis and recent theorisation of extinction as an entangled process, this article analyses the personal stakeholder testimonies from two different representatives of the North Slope whalers of Northern Alaska to the IWC – one in relation to the 1977 Alaska bowhead whaling controversy and the other in the context of the 2018 negotiations over streamlining Aboriginal Subsistence Whaling management and supporting greater flexibility and Indigenous autonomy. By comparing these two statements from very different points of history for the IWC and the governance of Indigenous whaling, this article illustrates some of the ongoing struggles for environmental governance to recognise extinction as a complex, multifaceted process that reverberates throughout human and more-than-human communities.
‘Providing a Layman's Guide to the Scheme’: Museum Computing, Professional Personas and Documentary Labour in the United Kingdom, 1967–1983
Authors: Baker James
Published: September 2024

Between the 1960s and early-1980s the museum sector in the United Kingdom (UK) was rapidly professionalised and systematised. A crucial moment in this transition was the creation in 1967 of the Information Retrieval Group of the Museums Association (IRGMA), and the subsequent launch of its system for the machine encoding and communication of museum catalogue records. The rise of IRGMA marked an inflection point in museological practice and the normalisation of computerised work within the UK museum profession, a moment when the desire for a ‘layman's guide to the scheme’ began to give way to new professional personas and forms of documentary labour. This article asks how cultures of museology and professional labour shifted in response to IRGMA. It argues that between the late 1960s and mid-1980s both the implementation of and the debate around computerised cataloguing disrupted the function of UK museums and how museum professionals imagined their labour. And by tracing the emergence of these cultures and their intersections with professional identity and labour practices, this article seeks to tease out the ways museum history can resonate with wider narratives of labour, expertise and technological innovation in contemporary British history.
Strong Finals: A prosodic feature projecting ‘more to come’ in a Danish urban dialect
Authors: Zachariassen Ditte
Published: September 2024

This article presents structural and interactional aspects of Strong Finals, a prosodic feature characterised by lengthening, increased volume, and non-falling intonation on word-final syllables. Interactionally, Strong Finals support five types of action: listing, projecting a description, stating conditions, asking questions, and announcing reported speech. In general, Strong Finals project that there is more to come, and this ‘more’ may in some cases be provided by either participant. Strong Finals are often found in multi-speaker settings, where they assist speakers in taking the floor or changing the topic. The article’s descriptions are based on recordings of natural spoken interaction in linguistically diverse areas in Aarhus, Denmark. Here, a new urban dialect has developed like other urban dialects that have been described in Copenhagen and other North Germanic cities. Strong Finals are a local phenomenon, however, and are not found in the Copenhagen studies.
The league of nations as an imperial assemblage: coloniality, indirect rule and the actualization of ‘International Law’
Authors: Memon Ahmed Raza
Published: September 2024

In this article, I reconceptualise the League of Nations as an Imperial Assemblage that embeds and is embedded by coloniality. Relying on the return to the League’s historisisation by Third World Approaches to International Law, I argue that we can understand the League as a governance body that works across scales of international, transnational and local actors, processes and structures to reiterate coloniality within the mandated territories. I utilise Deleuzian notions of assemblage alongside the concept of ‘coloniality’ within the literature of decolonial theory within International Relations and Sociology to show how the work of the League’s various actors, processes and structures across different scales made, actualised and evolved the laws on Forced Labour and Slavery from 1925 to 1932 in the inter-war era with a particular focus on Mandate Territories B and C.
Genetic Predisposition of Different Social Status Indicators in Men and Women
Authors: Fieder Martin , Huber Susanne
Published: September 2024

Although there is evidence that social status has a genetic basis, it is less known whether the genetic predisposition differs between men and women as well as among different status indicators and whether there are any intercorrelations among predispositions of status indicators. We therefore investigated the genetic predisposition for different indicators of social status separately for men and women, using polygenic scores obtained from the Wisconsin Longitudinal Study. We used multivariate polygenic regression of 7 different social status indicators on a total of 24 different polygenic scores. We find that in both men and women, wages and education show more associations with polygenic scores than the other status indicators. Also, the genetic predispositions for education and wages are correlated in both men and women, whereas in men more than in women, the genetic predispositions seem to cluster into wages and education on the one hand, and status indicators of position in the hierarchy, on the other hand, with being in a management position somewhere in between. These findings are consistent with an assumption of two different forms of selection pressure associated with either cognitive skill or dominance, which holds true particularly in men. We conclude that the genetic predisposition to higher social status may have changed even though the importance of the cultural trait of social status may have been very constant. Social status may thus be an example of a social trait of constant importance, but with a changing genetic predisposition.
Schön, dass es dich gibt!
Authors: Rietzler Stefanie , Grolimund Fabian , Wilke Marcus
Published: September 2024

Du bist goldrichtig, so wie du bist, und musst nichts Außergewöhnliches tun,
um von mir geliebt zu werden.

Diese Botschaft vermitteln die Tierfamilien Hase, Bär, Igel und Ente
in stimmungsvollen Bildern.

Eine Liebeserklärung an unsere Kinder, die zeigt, dass wir die Zeit mit
ihnen genießen und unser Alltag durch sie zu etwas Besonderem wird.
Visualizing mitochondrial dynamics at the nanoscale
Authors: Stephan Till , Ilgen Peter , Jakobs Stefan
Published: September 2024

The study of mitochondria is a formidable challenge for super-resolution microscopy due to their dynamic nature and complex membrane architecture. In this issue, Ren et al. introduce HBmito Crimson, a fluorogenic and photostable mitochondrial probe for STED microscopy and investigate how mitochondrial dynamics influence the spatial organization of mitochondrial DNA.
Drug-induced oxidative stress actively prevents caspase activation and hepatocyte apoptosis
Authors: Lambrecht Rebekka , Jansen Jasmin , Rudolf Franziska , El-Mesery Mohamed , Caporali Sabrina , Amelio Ivano , Stengel Florian , Brunner Thomas
Published: September 2024

Cell death is a fundamental process in health and disease. Emerging research shows the existence of numerous distinct cell death modalities with similar and intertwined signaling pathways, but resulting in different cellular outcomes, raising the need to understand the decision-making steps during cell death signaling. Paracetamol (Acetaminophen, APAP)-induced hepatocyte death includes several apoptotic processes but eventually is executed by oncotic necrosis without any caspase activation. Here, we studied this paradoxical form of cell death and revealed that APAP not only fails to activate caspases but also strongly impedes their activation upon classical apoptosis induction, thereby shifting apoptosis to necrosis. While APAP intoxication results in massive drop in mitochondrial respiration, low cellular ATP levels could be excluded as an underlying cause of missing apoptosome formation and caspase activation. In contrast, we identified oxidative stress as a key factor in APAP-induced caspase inhibition. Importantly, caspase inhibition and the associated switch from apoptotic to necrotic cell death was reversible through the administration of antioxidants. Thus, exemplified by APAP-induced cell death, our study stresses that cellular redox status is a critical component in the decision-making between apoptotic and necrotic cell death, as it directly affects caspase activity.