Serum levels of vitamin D and tumour necrosis factor-alpha in adults with metabolic syndrome
Authors:   Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria, Rahamon Sheu Kadiri ,   Department of Immunology, College of Medicine, University of Ibadan, Ibadan, Nigeria, Arinola Olatunbosun Ganiyu ,   Department of Immunology, College of Medicine, University of Ibadan, Ibadan, Nigeria, Charles-Davies Mabel Ayebatonyo ,   Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria, Akinlade Kehinde Sola ,   Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria, Olaniyi John Ayodele ,   Department of Haematology, College of Medicine, University of Ibadan, Ibadan, Nigeria, Fasanmade Adesoji Adedipe ,   Department of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria, Oyewole Oyediran Emmanuel ,   Department of Health Promotion and Education, College of Medicine, University of Ibadan, Ibadan, Nigeria, Owolabi Mayowa Ojo ,   Department of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria, Adebusuyi Jane Roli ,   Department of Medical Social Services, University College Hospital, Ibadan, Nigeria, Hassan Olufunke Olayemi ,   Department of Medical Social Services, University College Hospital, Ibadan, Nigeria, Ajobo Muhammed Babatunde ,   Dietetics Department, University College Hospital, Ibadan, Nigeria, Adigun Kehinde ,   Department of Family Medicine, University College Hospital, Ibadan, Nigeria, Ebesunun Maria Onomaghuan ,   Department of Chemical Pathology, College of Health Sciences, Olabisi Onabanjo University, Ago-Iwoye, Nigeria, Popoola Omolara Olutosin ,   Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria, Omiyale Wemimo ,   Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria, Agbedana Emmanuel Oluyemi ,   Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria
Published: April 2022

Introduction. Reports continue to show that a significant association exists between serum vitamin D level and metabolic syndrome (MS)-associated inflammation. However, information on the serum levels of vitamin D and alterations in inflammation in different vitamin D status is presently lacking. Aim. To determine the serum levels of vitamin D and TNF-α, and assess their possible relationship with gender in individuals with MS. Material and methods. Sixty adults with MS and 40 controls were enrolled into this case-control study. Serum vitamin D and TNF-α levels were measured and participants stratified into different vitamin D status. Results. None of the participants had vitamin D deficiency and the mean vitamin D level was similar in MS compared with the controls. However, TNF-α level was significantly higher in MS compared with the controls. Serum vitamin D level had significant inverse correlation with serum TNF-α level in MS. Also vitamin D level was significantly lower while TNF-α level was significantly higher in female-MS compared with the male-MS. Conclusion. Adults with MS have elevated TNF-α level which appears to be associated with the serum level of vitamin D. Also, females with MS have low vitamin D level and this may exacerbate the MS-associated inflammation in them.