bluuebunny/crossref_metadata_2025 huggingface dataset:
Associations of childhood hearing loss and adverse childhood experiences in deaf adults
Authors: Hall Wyatte C. , Dye Timothy D. V. , Siddiqi Shazia
Published: June 2023

Childhood trauma and adverse childhood experiences have a strong relationship with health disparities across the lifespan. Despite experiencing approximately doubled rates of trauma, Adverse Childhood Experiences (ACEs) are poorly characterized in deaf populations. We sought to characterize deaf-specific demographic factors and their association with multiple experiences of ACEs before the age of 18 years old. An analytical cross-sectional approach was used to ascertain associations of deaf-specific demographic factors and experiences with ACEs. The complete dataset included 520 participants for a total response rate of 56%. After adjusting for confounding effects, less severe hearing loss of 16–55 dB (2+ OR: 5.2, 4+ OR: 4.7), having a cochlear implant (2+ OR: 2.1, 4+ OR: 2.6), and not attending at least one school with signing access (2+ OR: 2.4, 4+ OR: 3.7) were significantly and independently associated with reported experiences of multiple ACEs. We conclude that factors associated with childhood hearing loss and language experiences increase risk of experiencing ACEs. Given the strong relationship between ACEs and poor social outcomes, early intervention clinical practice and health policies should consider interventions to support healthy home environments for deaf children.
Burden, predictors, and outcome of unconsciousness among under-five children hospitalized for community-acquired pneumonia: A retrospective study from a developing country
Authors: Mamun Gazi Md. Salahuddin , Sarmin Monira , Shahid Abu Sadat Mohammad Sayeem Bin , Nuzhat Sharika , Shahrin Lubaba , Afroze Farzana , Saha Haimanti , Shaima Shamsun Nahar , Sultana Mst. Shahin , Ahmed Tahmeed , Chisti Mohammod Jobayer
Published: June 2023

Despite the reduction of death from pneumonia over recent years, pneumonia has still been the leading infectious cause of death in under-five children for the last several decades. Unconsciousness is a critical condition in any child resulting from any illness. Once it occurs during a pneumonia episode, the outcome is perceived to be fatal. However, data on children under five with pneumonia having unconsciousness are scarce. We’ve retrospectively analyzed the data of under-five children admitted at the in-patient ward of Dhaka Hospital of icddr,b during 1 January 2014 and 31 December 2017 with World Health Organization classified pneumonia or severe pneumonia. Children presented with or without unconsciousness were considered as cases and controls respectively. Among a total of 3,876 children fulfilling the inclusion criteria, 325 and 3,551 were the cases and the controls respectively. A multivariable logistic regression analysis revealed older children (8 months vs. 7.9 months) (adjusted odds ratio, aOR 1.02, 95% CI: 1.004–1.04, p = 0.015), hypoxemia (aOR 3.22, 95% CI: 2.39–4.34, p<0.001), severe sepsis (aOR 4.46, 95% CI: 3.28–6.06, p<0.001), convulsion (aOR 8.90, 95% CI: 6.72–11.79, p<0.001), and dehydration (aOR 2.08, 95% CI: 1.56–2.76, p<0.001) were found to be independently associated with the cases. The cases more often had a fatal outcome than the controls (23% vs. 3%, OR 9.56, 95% CI: 6.95–13.19, p<0.001). If the simple predicting factors of unconsciousness in children under five hospitalized for pneumonia with different severity can be initially identified and adequately treated with prompt response, pneumonia-related deaths can be reduced more effectively, especially in resource-limited settings.
The use of respiratory rate-oxygenation index to predict failure of high-flow nasal cannula in patients with coronavirus disease 2019-associated acute respiratory distress syndrome: A retrospective study
Authors: Poopipatpab Sujaree , Nuchpramool Pruchwilai , Phairatwet Piyarat , Lertwattanachai Todspol , Trongtrakul Konlawij
Published: June 2023

Patients with mild-to-moderate coronavirus disease 2019 (COVID-19)-associated acute respiratory distress syndrome (ARDS) can be treated with a high-flow nasal cannula (HFNC). The use of the respiratory rate-oxygenation (ROX) index, calculated as the ratio of oxygen saturation (SpO2)/fractional oxygen (FiO2) to respiratory rate, in the first few hours after HFNC initiation can help identify patients who fail HFNC therapy later. However, few studies have documented the use of the ROX index during the period of HFNC therapy. Therefore, we aimed to demonstrate the diagnostic performance of the ROX index when calculated throughout the HFNC therapy period and to determine the best cut-off point for predicting HFNC failure. We conducted a retrospective study of patients with COVID-19-associated ARDS who commenced HFNC at the Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Thailand, between April 1 and August 30, 2021. We calculated the ROX index every 4 h throughout the HFNC therapy period and defined HFNC failure as a subsequent endotracheal tube intubation. The performance of the ROX index was analyzed using the area under the receiver operating characteristic curve (AUC). We applied the ROX index ≤ 4.88 to predict HFNC failure and obtained a new ROX cut-off point using Youden’s method. In total, 212 patients with COVID-19 treated with HFNC were included in the study. Of these, 81 patients (38.2%) experienced HFNC failure. The ROX index ≤ 4.88 demonstrated a reasonable performance in predicting HFNC failure (AUC, 0.77; 95% confidence interval [CI], 0.72–0.83; p<0.001). However, compared with the original cut-off point of ≤ 4.88, the new ROX index cut-off point of ≤ 5.84 delivered optimal performance (AUC, 0.84; 95% CI, 0.79–0.88; p<0.001), with a significantly better discriminative ability (p = 0.007). In conclusion, a ROX index ≤ 5.84 was found to be optimal for predicting HFNC failure in patients with COVID-19-associated ARDS.
Evaluation of biochemical, physiological traits and percentage of essential oil of sickleweed (Falcaria vulgaris) population in different geographical and climatic regions
Authors: Rahimi Mehdi , Kordrostami Mojtaba , Nasiri Jaber
Published: June 2023

Sickleweed (Falcaria vulgaris) is the name of a species of annual, and perennial herbaceous plants of the genus Falcaria. Climate change could negatively influnces the performance of various plant species in plant kingdom. In this study, 15 different sickleweed populations from seven provinces of the country were collected based on an unbalanced nest design with 10 replications and the percentage of essential oil, types of chlorophyll, phenol, proline, protein, and carotenoids were measured on them. The results showed that there was a significant difference between populations at the level of one percent for the studied traits. The results of the mean comparison showed that populations Ard-Shaban and Qaz-Ilan in terms of the evaluated traits and especially the percentage of essential oil were at the upper of the studied samples and selected as suitable populations. In addition, populations Gilan-Deylaman and Kur-Gerger-e Sofla were also identified as superior populations in terms of studied traits by cluster analysis and principle component analysis (PCA). Since the high level of proline and biochemical and physiological traits in plants can play a role in plants’ tolerance to stresses, therefore, populations with high values of these traits can be used in stress tolerance breeding programs. Therefore, in this study, populations Gilan-Deylaman and Kur-Gerger-e Sofla can be suitable populations for this purpose. In addition, the essential oil of this plant is used in the treatment of diseases, and therefore populations Ard-Shaban and Qaz-Ilan, which showed a high percentage of essential oil, can be used in breeding programs to increase the performance of this trait.
Soft Computing Techniques applied to solve Economic Emission Load Dispatch with the integration of Renewable Energy Sources
Authors: Soni Jatin , Bhattacharjee Kuntal
Published: June 2023

To enable accurate prediction and management of the output of renewable energy sources for optimal use.

To consider various physical constraints to make system more realistic.

To improve the efficiency and stability of power systems through advanced soft computing techniques.

Comparison of results with other recently developed algorithms.
Jian-Pi-Yi-Shen drug-containing serum promotes proliferation and activity of mouse osteoblasts
Authors: Cai Yuli , Liu Xiaochen , Ma Liang , Lv Wenxue , Wang Weiguo , Zhang Xingcai
Published: June 2023

Jian-Pi-Yi-Shen (JPYS) decoction is a traditional Chinese herbal formula. The present study aimed to investigate the effect of JPYS drug-containing serum on the proliferation and activity of mouse osteoblasts. Sprague‒Dawley rats were fed JPYS decoction, calcium supplement, or normal saline for 6 weeks, and the serum was collected. Mouse osteoblasts were treated with JPYS drug-containing serum, calcium supplement serum, or blank control serum. Cell proliferation was assayed using thiazolyl blue tetrazolium bromide. Levels of alkaline phosphatase, nitric oxide, and nitric oxide synthase in the culture medium were measured. The JPYS drug-containing serum significantly improved the proliferation of osteoblasts compared to the blank control serum and the calcium supplement serum. It also significantly increased the levels of alkaline phosphatase in the culture medium compared to the blank control serum and the calcium supplement serum. Treatment with JPYS drug-containing serum for 48 h and 72 h significantly increased the nitric oxide (NO) concentration in the culture medium compared to the blank control serum. The NOS activity of the osteoblasts was significantly increased by JPYS drug-containing serum compared to blank control serum and calcium supplement serum. All these results were enhanced that the JPYS decoction promotes the proliferation and activity of mouse osteoblasts. These effects may be the underlying mechanisms of JPYS decoction in treating osteoporosis.
Validación del CESQT en trabajadores colombianos: Un estudio psicométrico en tiempos de COVID-19
Authors: Hermosa Rodríguez Angélica , Gil LaOrden Pedro , Gil Monte Pedro
Published: June 2023

El objetivo de este estudio fue analizar la validez factorial del modelo psicométrico del Cuestionario para la Evaluación del Síndrome de Quemarse por el Trabajo (CESQT) en una muestra multiocupacional de trabajadores colombianos. Se hipotetizó un modelo de cuatro factores con base en la estructura factorial del modelo original. Los participantes fueron 153 trabajadores que desempeñan diversos roles en empresas ubicadas en Colombia. El diseño fue transversal descriptivo de una sola muestra, ex post facto. Se aplicó el CESQT que se compone de cuatro dimensiones: Ilusión por el trabajo (5 ítems), Desgaste psíquico (4 ítems), Indolencia (6 ítems) y Culpa (5 ítems). Las propiedades psicométricas fueron examinadas mediante Análisis factorial confirmatorio (AFC) y fiabilidad (alfa de Cronbach). Los ítems presentaron valores estadísticos y psicométricos adecuados, así como las escalas. El modelo presentó un ajuste aceptable a los datos: GFI = .858, RMSEA = .066 (.051-.079), NNFI = .913, CFI = .927. La consistencia interna fue alta para todas las escalas del instrumento (? = .79 hasta ? = .87). Los resultados indican que el CESQT es un instrumento con suficiente validez psicométrica para evaluar el síndrome de quemarse por el trabajo (SQT) en el contexto cultural colombiano.
mpacto psicosocial de la desaparición forzada. Una visión de las madres que buscan a su ser querido
Authors: Linares Acuña Gabriela , Álvarez Bermúdez Javier
Published: June 2023

Desaparición Forzada una realidad más frecuente en nuestra sociedad: las cifras refieren que en México hay 61, 637 personas desaparecidas para marzo de 2020. Pero lo más importante es considerar los mecanismos que son necesarios para la atención de aquellos familiares que buscan a su ser querido, principalmente las madres de desaparecidos, quienes se ven afectadas en el aspecto físico y psicológico. Objetivo: realizar un análisis del impacto psicosocial a partir de las emociones, pensamientos, afrontamiento y apoyo social en las madres de desaparecidos y su contribución en el proceso de búsqueda. Las participantes fueron diez madres de desaparecidos del Estado de Coahuila, México. Metodología: cualitativa Técnica de recolección de datos: una entrevista semiestructurada. Los datos cualitativos se sometieron a un análisis del discurso. Resultados: las emociones que denotan las participantes al inicio del proceso de búsqueda son muy específicas, luego se diversifican y se multiplican, se vuelven más intensas y afectan directamente dicho proceso. Los pensamientos, se centran principalmente en evasivas y negación ante los hechos de desaparición; el afrontamiento afecta directamente su vida cotidiana, sus hábitos y costumbres. El apoyo social percibido se enfoca en sus familias y en grupos o asociaciones que los asisten para llevar a cabo la búsqueda.
Síntomas de depresión y calidad de vida relacionada con la salud en personas mayores: una revisión
Authors: Olaya Rúa Leidy Carolina , Córdoba Sánchez Verónica , Velilla Jiménez Lina Marcela , Hernández Calle Jonathan Andrés
Published: June 2023

El objetivo de este estudio fue sintetizar la evidencia de la literatura científica sobre la calidad de vida relacionada con la salud en las personas mayores con síntomas de depresión. Se realizó una revisión sistemática de la literatura científica publicada entre 2015 y 2020 en las bases de datos Pubmed, Scielo y Scopus. Se incluyeron 35 artículos en los cuales se reportó una estrecha relación entre la calidad de vida relacionada con la salud y los síntomas de depresión, mediada por condiciones físicas y psicosociales entre las cuales se encuentran el tener enfermedades crónicas, dolor persistente, comorbilidades, disminución de la independencia, bajos ingresos, alto porcentaje de grasa corporal, sedentarismo, vivir solo, pertenecer al género femenino y carecer de cuidadores empáticos.
Discriminación racial y Determinantes Sociales de la salud en niños y niñas migrantes: revisión narrativa
Authors: Venegas León Camila , Pedrero Castillo Victor , Chepo Chepo Macarena
Published: June 2023

Objetivo: Analizar la relación entre Determinantes Sociales de la Salud (DSS) y discriminación en niños, niñas y adolescentes migrantes a partir de la información disponible en la literatura científica. Método: Revisión narrativa de estudios primarios publicados entre el 2008 y 2021 en bases de datos PubMed y Web of Science. Se utilizaron los descriptores Psychological/Social Discrimination, Racism, Social Stigma, Social Determinants of Health, Public Health, Health Equity, Transients and Migrants, Refugees, Emigrants and Immigrants, Undocumented Immigrants, Child, Adolescent, Child, Preschool. Los operadores booleanos utilizados fueron AND y OR. Se incluyeron artículos observacionales (analíticos o descriptivos) que evaluaran la relación entre discriminación racial y DSS, publicados en ingles o español. La población de estudio fueron niños, niñas y adolescentes. La selección de artículos se realizó siguiendo las recomendaciones PRISMA. La calidad de la evidencia fue evaluada mediante las recomendaciones CASPe. Resultados: De un total de 1249 artículos identificados, 55 fueron incluidos. La mayor cantidad de artículos identificó el efecto de la relación entre discriminación racial y migración en ámbitos de salud mental negativa. Fue escasa la evidencia respecto de determinantes estructurales, sin embargo destaca la relación entre discriminación racial y el efecto moderador de la familia y la escuela. Conclusiones: Analizar la discriminación racial que perciben niños y niñas migrantes mediante un enfoque de DSS permite identificar áreas sensibles al desarrollo estrategias de reducción de inequidades en este grupo. Palabras claves: Discriminación, Racismo, Estigma Social, Determinantes Sociales de la Salud, Salud Pública, Equidad en Salud, Emigrantes e Inmigrantes, Niño, Adolescente, Preescolar.
Awareness of the Environmental Impact of Clothing Production and Consumption among Slovenian Women Customers
Authors: Sedej Tanja , Toroš Jani
Published: June 2023

The textile industry, where clothing industry has an important share, is one of the most polluting industries in the world, wherefore clothing consumption has a significant impact on the environment. The consumption of clothing has been increasing quickly along with the growth of the middle classes in developing nations and the fast-fashion business model. At the same time, consumers are becoming more and more aware of the importance of sustainability, and they have been changing their consumer behaviour accordingly. In this study, we focused our attention on awareness of the environmental impact of clothing production and consumption from the point of view of consumer knowledge, linked to different generations, marital statuses, living environments, family income and type of purchasing store. The study reveals a high-level consumer-evaluated knowledge regarding the effects of clothing production and consumption, but also still the purchasing preference in fast fashion stores.
HUBUNGAN ANTARA EXPERIENCED OF WORKPLACE INCIVILITY BEHAVIOR DENGAN KEPUASAN KERJA PADA PERAWAT DI RUMAH SAKIT NASIONAL DIPONEGORO
Authors: Malau Tiolo Helviana , Prasetyo Anggun Resdasari
Published: June 2023

Penelitian ini bertujuan untuk mengetahui hubungan antara experienced of workplace incivility behavior dengan kepuasan kerja pada perawat di Rumah Sakit Nasional Diponegoro. Experienced of workplace incivility behavior adalah perilaku menyimpang dengan intensitas rendah yang diterima seseorang di tempat kerja dan memiliki maksud untuk menyakiti individu tersebut, melanggar norma tempat kerja, dan norma saling menghormati. Kepuasan kerja adalah perasaan positif yang ditunjukkan individu terhadap pekerjaannya yang terkait dengan hasil evaluasi terhadap pekerjaan dan penyesuaian diri yang sehat atas kondisi dan situasi kerja. Subjek dalam penelitian ini sebanyak 68 perawat dengan teknik pengambilan sampel adalah convenience sampling. Metode pengumpulan data menggunakan dua skala psikologi, yakni skala experienced of workplace incivility behavior dengan 42 aitem (α=0,935) dan skala kepuasan kerja dengan 19 aitem (α=0,892). Metode analisis data yang digunakan adalah analisis korelasi Rank Spearman dengan hasil rxy= -0,469 dengan nilai signifikansi korelasi p = 0,000 (p<0,05). Hasil tersebut menunjukkan adanya hubungan negatif antara experienced of workplace incivility behavior dengan kepuasan kerja. Semakin tinggi experienced of workplace incivility behavior maka semakin rendah kepuasan kerja perawat, dan begitu pula sebaliknya.
PERAN ONLINE SUPPORT GROUP PADA IBU PASCA MELAHIRKAN ANAK PERTAMA
Authors: Hasanah Uswatun , Helmi Avin Fadhila
Published: June 2023

Perempuan pasca melahirkan anak pertama memiliki risiko mengalami baby blues bahkan postpartum depression. Kondisi tersebut berimplikasi terhadap kondisi fisik, produktivitas ASI, dan masalah pada pengasuhan bayi. Dukungan sosial sangat diperlukan bagi ibu setelah melahirkan anak pertama. Salah satu alternatif dukungan sosial yang bisa diperoleh ibu adalah melalui Online Support Group (OSG), merupakan sebuah komunitas ibu muda yang bertujuan untuk saling berbagi informasi serta dukungan seputar perawatan ibu setelah melahirkan dan pengasuhan anak. Penelitian ini bertujuan untuk memahami pengalaman ibu pasca melahirkan anak pertama yang tergabung dalam OSG. Melalui pendekatan kualitatif, tiga ibu pasca melahirkan anak pertama diwawancarai menggunakan teknik in-deepth interview dengan analisis Interpretative Phenomenological Analysis (IPA). Hasil penelitian ini menemukan bahwa OSG berperan positif dalam mengurangi faktor risiko ibu setelah melahirkan anak pertama hal ini disebabkan karena adanya need for information yang berfungsi menjadi sumber penguatan sesama ibu baru. Komunikasi antar anggota OSG hanya terbangun di forum besar tidak terjalin secara personal, meski demikian terdapat kepercayaan informan kepada OSG dengan hadirnya peer expert yang banyak memberikan informasi berdasarkan latar belakang keilmuan dan pengalaman mengasuh anak. Bentuk dukungan yang diperoleh dari OSG adalah dukungan informasi, dukungan peer expert untuk mendapatkan validasi informasi, dukungan emosional, dukungan penilaian, dan dukungan instrumental.
Keterkaitan antara Dukungan Teman Sebaya, dan Manajemen Waktu dengan Prokrastinasi Mahasiswa Fakultas Psikologi Universitas Selamat Sri dalam Menyelesaikan Tugas Ujian Akhir Semester
Authors: Rusmono Danny Ontario
Published: June 2023

Penelitian ini bertujuan untuk melihat apakah terdapat hubungan yang simultan antara dukungan teman sebaya dan manajemen waktu dengan prokrastinasi. Penelitian ini menggunakan pendekatan kuantitatif korelasional. Subjek pada penelitian ini dilakukan kepada 72 sampel mahasiswa Fakultas Psikologi Universitas Selamat Sri dengan disproportionate stratified random sampling. Metode analisis data menggunakan analisis regresi berganda dan korelasi Pearson. Hasil uji hipotesis mayor dengan analisis regresi berganda menunjukkan p = .025 (p<.05) artinya terdapat hubungan yang simultan antara dukungan teman sebaya dan manajemen waktu dengan prokrastinasi Mahasiswa Fakultas Psikologi Universitas Selamat Sri. Uji korelasi Pearson dilakukan untuk menguji dua hipotesis minor. Uji hipotesis minor (1) terdapat hubungan antara dukungan teman sebaya dengan prokrastinasi menunjukkan rxy = -.453 dan p = .012 (p<.05) artinya terdapat hubungan negatif antara dukungan teman sebaya dengan prokrastinasi. Uji hipotesis minor (2) terdapat hubungan manajemen waktu dengan prokrastinasi menunjukkan rxy = -.406 dan p = .026 (p<.05) artinya terdapat hubungan negatif antara manajemen waktu dengan prokrastinasi.
PENGALAMAN REMAJA LAKI-LAKI SEBAGAI PENARI REOG: SEBUAH INTERPRETATIVE PHENOMENOLOGICAL ANALYSIS
Authors: Andini Kartika Ratri , Alfaruqy Muhammad Zulfa
Published: June 2023

Masa remaja merupakan masa bagi individu untuk berusaha melakukan eksplorasi terhadap hal-hal baru yang ada di sekitar individu. Berbagai tren yang berasal dari luar, turut memengaruhi minat remaja untuk memiliki kemauan mengembangkan kebudayaan bangsa, termasuk di dalamnya kesenian reog. Penelitian ini bertujuan untuk mengetahui dan memahami pengalaman remaja laki-laki sebagai penari reog. Metode penelitian yang digunakan adalah kualitatif fenomenologis. Partisipan dalam penelitian ini adalah tiga orang remaja laki-laki berusia 13-18 tahun dan aktif sebagai penari reog yang dipilih secara purposif. Pengambilan data dalam penelitian menggunakan metode in-depth interview semi terstruktur dan menggunakan teknik analisis data Interpretative Phenomenological Analysis (IPA). Hasil yang ditemukan dalam penelitian ini dikelompokkan menjadi dua tema induk, yaitu (1) intensi penari reog yang didalamnya terdapat keinginan menjadi penari, social support, proses menjadi penari, entertaining possession, konflik penari reog, serta manajemen konflik penari; dan (2) pemaknaan pengalaman yang terdiri dari manfaat menjadi penari reog, kepedulian terhadap budaya, serta risiko menjadi penari reog. Hasil penelitian berperan dalam meluruskan stereotipe terhadap penari reog yang ada di masyarakat. Penelitian yang dilaksanakan diharapkan juga dapat berkontribusi dalam memupuk kepedulian terhadap kebudayaan pada masyarakat, khususnya di kalangan remaja.
Analgesic Profile in Intensive Observation Room (Ruang Observasi Intensif/ ROI) Dr. Soetomo General Hospital Surabaya
Authors: Manurung Bunga Priscilla Rotua , Maulydia Maulydia , Rochmanti Maftuchah , Rehatta Nancy Margarita
Published: June 2023

Introduction: Pain is a condition that the majority of critical care patients will possibly suffer at some point during their stay in the intensive care unti (ICU). In both medical and surgical ICU patients, the incidence of considerable pain is still 50% or greater. Analgesic administration is considered one of the most effective pain managements. While useful, it can cause detrimental effects if not used according to its indications and regulations.Objective: To obtain the analgesic profile used in intensive observation room (ruang observasi intensif/ROI) Dr. Soetomo General Hospital Surabaya.Methods: This study is a retrospective descriptive study with 537 medical records met the inclusion criteria.Result: The most frequent analgesic used is metamizole (44.41%) and paracetamol (16.08%) while ketamine was used the least (0.24%). Most commonly used analgesic adjuvants is phenytoin (6.12%). The amount of single drug administration (52.70%) is more frequent than multimodal analgesic (47.30%). Metamizole with paracetamol is the most popular analgesic combination (20.74%), followed by metamizole with tramadol (14.17%), and metamizole with fentanyl (12.99%). The most common procedures recorded are obstetrics and gynaecological (29.98%), cranial and general surgery with the same result (21.42%), and orthopaedic (12.29%). 205 samples with Wong-Baker FACES Pain Ratings Scales stated that there is an increase in patients who do not experience pain after administration of analgesics (N=25 to N=132), patients that underwent mild pain decreased (N=134 to N=65), and patients with moderate and severe pain also decreased (N=43 to N=8 and N=3 to N=0 respectively).Conclusion: Non-opioid analgesic dominates the analgesic profile in ROI Dr. Soetomo General Hospital Surabaya compared to opioids that generally used the most worldwide. Giving analgesics to patients has been proven successful in reducing the pain degree.
An assessment of the fourth law of Kuryłowicz: does prototypicality of meaning affect language change?
Authors: De Smet Isabeau
Published: June 2023

According to the (in)famous fourth law of Kuryłowicz (K4), when a morphological doublet arises in a language, the newer form becomes associated with the prototypical, basic meaning, while the old form takes a secondary meaning. This paper takes a first attempt at a more thorough inquiry of K4 to assess whether prototypicality of meaning has an effect on morphological change. Three studies on historical Dutch are taken on: -enversus -splurals, the apocope of schwa and the apocope of -de.The effects of prototypicality are analysed both on a token level (differences in meaning within lemmas) as well as on a type level (differences between lemmas). As proxies for prototypicality of meaning (psycho)linguistic predictors are used, such as concreteness, age of acquisition, chronology of meaning, meaning frequency and metaphor. Results show no clear effect of prototypicality on a token level, but they do suggest an effect on a type level: more concrete meanings tend to show up more often with the newer variant. Yet these results may also be ascribed to iconicity as the newer variants in these cases are the shorter ones and concrete meanings tend to be represented by shorter words than abstract ones.
Three solutions for discrete anisotropic Kirchhoff-type problems
Authors: Bohner Martin , Caristi Giuseppe , Ghobadi Ahmad , Heidarkhani Shapour
Published: June 2023

In this article, using critical point theory and variational methods, we investigate the existence of at least three solutions for a class of double eigenvalue discrete anisotropic Kirchhoff-type problems. An example is presented to demonstrate the applicability of our main theoretical findings.
Alexander of Aphrodisias and the Active Intellect as Final Cause
Authors: Guyomarc’h Gweltaz
Published: June 2023

In his own De anima, Alexander of Aphrodisias famously identifies the “active” (poietikon) intellect with the prime mover in Metaphysics Λ. However, Alexander’s claim raises an issue: why would this divine intellect come in the middle of a study of soul in general and of human intellection in particular? As Paul Moraux asks in his pioneering work on Alexander’s conception of the intellect, is the active intellect a “useless addition”? In this paper, I try to answer this question by challenging a solution according to which the active intellect would intervene directly with the material intellect to trigger its ordinary working. I argue that the active intellect acts as a final cause, both for human intellect and for its ordinary objects of thought. The active intellect is twice “cause of the intellection”, i.e. cause of the actualization of human thought: once (i) when it offers thought occasions for thinking through objects, and again (ii) when it actualizes mediately the human intellect itself in its development. This reading agrees with Alexander’s usual position about the prime mover’s causality. It accounts for the multiplicity of expressions with which Alexander describes the causality of the active intellect in his De anima. It also explains why the development of human intellect has been described without direct reference to active intellect, since substances do not aim directly at the First cause, but their aiming at it is mediated by their desire for their own good.
L’articulation des chapitres 19 et 20 du traité VI, 2 [43] de Plotin. La priorité du genre sur ses espèces
Authors: Mouflier Camille
Published: June 2023

Chapter 20 of Plotinus’ treatise VI, 2 [43] has received particular attention because it seems to deal with the Intellect. However, the connection of this chapter with chapter 19 is problematic insofar as the latter deals with the ways in which species are generated by the first genera. Our aim will be to show that chapter 20 can only be understood in the light of the notion of genus. More precisely, Plotinus’ aim in this chapter is to demonstrate the priority of the genus over its species by means of the theory of double activity. In order to demonstrate this point, the notion of Intellect is introduced by Plotinus as a model (παράδειγμα) to conceive this priority. We will study successively these two chapters to justify this point, insisting on the link between them as well as on the reinterpretation of some key Aristotelian concepts. This study also shows that the use of the comparison with science allows Plotinus to justify the primacy of the intelligible totalities that are the Soul and the Intellect as well as the generation of their respective parts, the particular souls and the particular intellects.
Britain’s Failed Attempt at Monetary and Fiscal Exceptionalism
Authors: Marsh David
Published: June 2023

The autumn 2022 economic upheavals that brought down British Prime Minister Liz Truss’s government represented an ultimate extension of a high-risk exercise in British exceptionalism: the June 2016 referendum decision to leave the European Union. The ill-fated 23 September 2022 ‘mini budget’ introduced by Truss and Kwasi Kwarteng, her chancellor of the exchequer – like the referendum outcome six years earlier – was a landmark gesture of national independence. ‘The most ambitious and disastrous budget in modern British history’ illustrated how the intertwining forces of politics and economics set limits on ‘go it alone’ policies. The lessons reverberate beyond the UK’s borders.
Humor style predicts sarcasm use – evidence from Turkish speakers
Authors: Branowska Katarzyna , Kandemirci-Bayız Duygu , Abayhan Yasemin , Akdeniz Büşra , Banasik-Jemielniak Natalia
Published: June 2023

Humor and sarcasm are closely related – sarcasm is often identified with aggressive humor or humorous mockery. Research in this area is common in Western European languages, but not in non-WEIRD populations. The aim of the study was to examine the relationship between humor styles and sarcasm use in the Turkish-speaking population. We also attempted to predict the use of different sarcasm types (general sarcasm, embarrassment diffusion, face-saving, and frustration diffusion) by the scores of the Humor Styles Questionnaire (Martin, Rod A., Patricia Puhlik-Doris, Gwen Larsen, Jeanette Gray & Kelly Weir. 2003. Individual differences in uses of humor and their relation to psychological well-being: Development of the Humor Styles Questionnaire. Journal of Research in Personality 37(1). 48–75) scales (aggressive, affiliative, self-enhancing, and self-defeating humor). The data from 329 Turkish-speaking participants were collected: 250 women and 79 men (M
age = 37; SD = 12.32; age range: 18–70). Participants filled out online questionnaires including Sarcasm Self-Report Scale (Ivanko, Stacey L., Penny M. Pexman & Kara M. Olineck. 2004. How sarcastic are you? Individual differences and verbal irony. Journal of Language and Social Psychology 23(3). 244–271) adapted into Turkish, and the Humor Styles Questionnaire (Martin, Rod A., Patricia Puhlik-Doris, Gwen Larsen, Jeanette Gray & Kelly Weir. 2003. Individual differences in uses of humor and their relation to psychological well-being: Development of the Humor Styles Questionnaire. Journal of Research in Personality 37(1). 48–75) in Turkish adaptation (Tümkaya, Songül. 2011. Humor styles and socio-demographic variables as predictor of subjective well-being of Turkish university students. Egitim ve Bilim 36(160). 158–170). The results showed positive correlations between all humor styles and all sarcasm types, with the strongest correlation with aggressive humor. Regression analysis was used to find predictors of sarcasm use. Our results show that aggressive humor style is the main predictor of all self-reported sarcasm use scales.
Artificial Bee Colony algorithm in estimating kinetic parameters for yeast fermentation pathway
Authors: Ismail Ahmad Muhaimin , Remli Muhammad Akmal , Choon Yee Wen , Nasarudin Nurul Athirah , Ismail Nor-Syahidatul N. , Ismail Mohd Arfian , Mohamad Mohd Saberi
Published: June 2023

Analyzing metabolic pathways in systems biology requires accurate kinetic parameters that represent the simulated in vivo processes. Simulation of the fermentation pathway in the Saccharomyces cerevisiae kinetic model help saves much time in the optimization process. Fitting the simulated model into the experimental data is categorized under the parameter estimation problem. Parameter estimation is conducted to obtain the optimal values for parameters related to the fermentation process. This step is essential because insufficient identification of model parameters can cause erroneous conclusions. The kinetic parameters cannot be measured directly. Therefore, they must be estimated from the experimental data either in vitro or in vivo. Parameter estimation is a challenging task in the biological process due to the complexity and nonlinearity of the model. Therefore, we propose the Artificial Bee Colony algorithm (ABC) to estimate the parameters in the fermentation pathway of S. cerevisiae to obtain more accurate values. A metabolite with a total of six parameters is involved in this article. The experimental results show that ABC outperforms other estimation algorithms and gives more accurate kinetic parameter values for the simulated model. Most of the estimated kinetic parameter values obtained from the proposed algorithm are the closest to the experimental data.
Resonant inelastic tunneling using multiple metallic quantum wells
Authors: Zhang Yiyun , Lepage Dominic , Feng Yiming , Zhao Sihan , Chen Hongsheng , Qian Haoliang
Published: June 2023

Tunnel nanojunctions based on inelastic electron tunneling (IET) have been heralded as a breakthrough for ultra-fast integrated light sources. However, the majority of electrons tend to tunnel through a junction elastically, resulting in weak photon-emission power and limited efficiency, which have hindered their practical applications to date. Resonant tunneling has been proposed as a way to alleviate this limitation, but photon-emissions under resonant tunneling conditions have remained unsatisfactory for practical IET-based light sources due to the inherent contradiction between high photon-emission efficiency and power. In this work, we introduce a novel approach that leverages much stronger resonant tunneling enhancement achieved by multiple metallic quantum wells, which has enabled the internal quantum efficiency to reach ∼1 and photon-emission power to reach ∼0.8 µW/µm2. Furthermore, this method is applicable with different electronic lifetimes ranging from 10 fs to 100 fs simultaneously, bringing practical implementation of IET-based sources one step closer to reality.
Pan-cancer analysis, providing a reliable basis for IDO2 as a prognostic biomarker and target for immunotherapy
Authors: Mo Bangqian , Zhao Xiashuang , Wang Yongfeng , Jiang Xianglai , Liu Deming , Cai Hui
Published: June 2023

Objectives

Indoleamine 2,3-dioxygenase 2 (IDO2) is a homologous protein of the classical immune negative regulator Indoleamine 2,3-dioxygenase 1 (IDO1) that is indispensable in the metabolism of tryptophan and is closely related to the pathogenesis and progression of tumors. Nevertheless, the mechanism of IDO2 in malignant tumors is not fully understood warranting further research.

Methods

Data related to IDO2 in pan-cancer was obtained from The Cancer Genome Atlas (TCGA) database. Differences in IDO2 expression between pan-cancerous and corresponding normal tissues were analyzed, and survival rates were analyzed using Kaplan–Meier. The correlation between IDO2 expression and tumor-infiltrating immune cells (TIICs), tumor mutational load (TMB), microsatellite instability (MSI), mismatch repair (MMR), immune checkpoints (ICP) and DNA methyltransferase (DNMT) was investigated by Spearman correlation analysis. Functional enrichment analysis of IDO2 was performed to explore its biological and molecular roles in tumors.

Results

Our comprehensive pan-cancer analysis showed that IDO2 expression was significantly altered in most malignancies and correlated with poor prognosis. The expression of IDO2 was strongly associated with the progression of several tumors and excessive infiltration of immune cells in the tumor microenvironment (TME). The expression of IDO2 significantly correlated with TMB, MSI, MMR and ICP in different tumors. More importantly, functional enrichment analysis showed that IDO2 acts primarily through the regulation of antitumor immunological processes. RT-PCR validated IDO2 expression in multiple cancer cell lines, consistent with the bioinformatic analysis results.

Conclusions

IDO2 is closely related to tumor genesis and immunity, and can be used as an adjunct for the diagnosis and prognosis assessment of many tumors.
Differential expression and functions of miRNAs in bladder cancer
Authors: Huang Hao , Pi Xiaowu , Xin Chenqi , Gong Chen , Guo Feng , Wang Yang , Xiong Ying
Published: June 2023

Bladder cancer (BC), a urologic disease, commonly occurs globally and is very invasive. Patients with invasive BC have low 5-year survival rate. Hence, the mechanisms underlying BC development and progression should be elucidated. MicroRNAs (miRNAs), as common noncoding RNAs, are receiving increasing attention because of their biological functions. The irregular expression patterns of miRNAs are linked to BC occurrence; therefore, determining the functions of miRNAs in abnormally expressed BC tissues might enable to elucidate the pathogenetic mechanism of BC and offer new markers for the prognosis, diagnosis, and therapy of BC. Here, we consolidate the primary roles of miRNAs with atypical expression in BC development as well as their association with BC pathological grades and chemotherapy resistance development in patients with BC.
The inhibitory function of GDF11/BMP11 in liver cancer by inducing apoptosis and ROS–JNK pathway
Authors: Zhang Yonghui , Wang Chen , Li Jiaxin , Jin Lishan , Ding Wenxuan , Liu Huan , Zhou Na , Ren Zhengni , Zhang Junqi , Wei Yong , Li Lei , Pan Lianhong , Liu Dan
Published: June 2023

Objectives

The inhibitory mechanism of growth differentiation factor 11 (GDF11) on liver cancer cells is unknown. Our study applied RNA-Seq to investigate the transcriptome results of liver cancer cells after GDF11 treatment, revealing the underlying molecule mechanisms of the inhibitory roles of GDF11 on liver cancer cells.

Methods

First, mRNA and protein expression levels of GDF11 were detected through the Oncomine database and tissue microassay. In vitro, Smad2/3 signaling was checked using Western blot in liver cancer cell lines (MHCC97-H and HCCLM3) after GDF11 treatment. The growth effect of GDF11 on liver cancer cells was investigated by microscopic observation and the Cell Counting Kit-8 experiment. The underlying mechanisms were explored by transcriptome experiments, flow cytometry, electron microscopy, and Western blot.

Results

GDF11 was reduced in human malignant liver tissues and cell lines compared to normal liver tissues and cell lines. GDF11 activated Smad2/3 signaling and decreased cell viability in liver cancer cell lines (MHCC97-H and HCCLM3). RNA-Seq analysis found that 39 genes were significantly changed, 9 genes were significantly downregulated, and 30 genes were significantly upregulated. GDF11 could affect apoptosis and ROS, and JNK signaling.

Conclusions

GDF11 may have anti-liver cancer effects by affecting Smad2/3 and inducing apoptosis through the ROS-JNK pathway.
Rückführung dimensioneller Messungen an Großbauteilen für Windenergiesysteme
Authors: Kniel Karin , Heißelmann Daniel , Franke Matthias
Published: June 2023

Die hochgenaue und zuverlässige Messung von Großbauteilen für Windenergiesysteme auf Groß-Koordinatenmessgeräten (Groß-KMG) ist für deren störungsfreien Einsatz unter höchsten Belastungen unerlässlich. Um der Industrie auf diesem Gebiet Kalibrierungen auf höchstem Niveau sowie weitere messtechnische Unterstützung anbieten zu können, wurde in der Physikalisch-Technischen Bundesanstalt ein Groß-KMG etabliert. In diesem Beitrag werden die jüngsten Entwicklungen zu neuen Ansätzen für die Geometriefehlererfassung für große Messvolumina vorgestellt. Darüber hinaus gibt es Einblick in die Optimierungsstrategie für das neuartige Kalibrierverfahren M3D3 sowie in die Erweiterung des Virtuellen Koordinatenmessgerätes (VCMM) für die simulationsbasierte Messunsicherheitsbestimmung auf Groß-KMG.
Wittgenstein and Repetition
Authors: Arielli Emanuele
Published: June 2023

“I myself still find my way of philosophizing new, & it keeps striking me so afresh, & that is why I have to repeat myself so often. […] [R]epetitions […] [f]or me […] are necessary.” (CV 1998: 3e) Wittgenstein's style is well known for its recursive—and according to some interpreters, even obsessive-compulsive—quality, but they are part of a thinking method: “I suggest repetition as a means of surveying the connections.” (AWL 1979: 43) The style also mirrors recurring ideas such as “concepts are not for use on a single occasion” (Z 1981: 568), or the “bustle (Getriebe) of life […] comes about only through constant repetition” (RPP 1980b: 625 – 626).

The aim of this essay is to show how the notion of repetition (Wiederholung) plays a significant role in the evolution of Wittgenstein's thought. It is the manifestation of a philosophical praxis, and although the notion of repetition remains in the background, it is a constant presence in his production, often featuring alongside his best-known concepts, like rule following, aspect seeing, and his thoughts on music and mathematics. This article will examine the different ways in which Wittgenstein reflects on the question of repetition in relation to the idea of identity, variation, and diversity, and as a fundamental aspect of human practice that is not the mere manifestation of underlying rules or principles, but a necessary condition for their emergence.
Wahrheit in Wittgensteins Spätphilosophie
Authors: Forster Daniel
Published: June 2023

Truth in Wittgenstein′s Later Philosophy. In this paper I attempt to examine Wittgenstein′s understanding of truth in his later period. In doing so, I orient myself primarily on the remarks published as Philosophical Investigations and On Certainty. My primary aim in the destructive part is to show that his later philosophy neither espouses a redundancy and deflationary, nor an epistemic and anti-realist conception of truth. Both strands of interpretation are strongly represented in the debate. An examination of Wittgenstein’s remarks on the correspondence theory of truth will also shed some light on his thoughts about truth. Furthermore, in the preceding constructive part of this paper, I will try to demonstrate that (1) for Wittgenstein there is a strong link between truths that we accept based on our certainties and our use of the term “truth” and (2) that skepticism about truth, which claims that all accepted truths in our Weltbild (“world-view”) could be actually false, fails to give any meaning to its use of “truth”. This culminates in Wittgenstein′s insight, that the question of what truth is can only be answered relative to the Weltbild. Therefore, talking about truths that transcend our Weltbild becomes nonsense.
Wittgensteins Manuskriptbände aus dem Jahr 1929
Authors: Figueiredo Florian Franken
Published: June 2023

Wittgenstein's manuscript volumes from 1929: Reflections on the Chronology of MSS 105 – 107. In this paper I identify the evidence that might be used to establish a viable chronology for Wittgenstein’s writing of his manuscript volumes 105 – 107 and sections thereof. Since Wittgenstein omits to date his entries in these three 1929 volumes between February 15 and September 11, the evaluation of these different chronologies must remain somewhat speculative, but the justifications for each can, as I will show, be revealingly compared. I also argue that such attempts at a genealogical appreciation of Wittgenstein’s remarks is not only worthwhile on its own terms but it also further paves the way for an increased understanding of Wittgenstein’s philosophy. I articulate and evaluate three possible chronologies for the year 1929 and argue for the one I take to be the most plausible.
The Copyright Status of Wittgenstein’s Works
Authors: Lavazza Michele
Published: June 2023

Determining the copyright status of a literary work is not always straightforward, because copyrights are territorial and the relevant laws differ significantly country by country. In some legislations, for example, a work’s copyright status may depend on the publication date, on whether the publication was posthumous, on the quantity and quality of editorial interventions the manuscript underwent before publication, etc.

2021 marked the 70th anniversary of Wittgenstein’s death. In many countries, the duration of the copyright term is the author’s life plus 70 years. Thus, as of the moment of this writing, it is important to attempt a comprehensive analysis and to try to determine whether, where and why his manuscripts and his published works are in the public domain.

This paper clarifies the general principles of copyright and describes the rules and best practices that must be followed in the context of internet publications. Additionally, it examines the factors that make it particularly challenging to ascertain the copyright status both of Wittgenstein’s published works and of the transcriptions of his manuscripts. Lastly, it provides a detailed account of the copyright status of some of Wittgenstein’s works that were published in the second half of the 20th century, proving that they are in the public domain in most countries.
Wittgenstein’s Notebooks, Diaries and Diaristic Remarks
Authors: Somavilla Ilse
Published: June 2023

In my paper I will discuss the difference between Wittgenstein’s notebooks, personal diaries and his so called diaristic remarks scattered throughout the Nachlass. This includes a distinction between his philosophical and his diaristic entries. Secondly, I will outline the editing history of Wittgenstein’s Notebooks 1914 – 1916, his Secret Diaries (Geheime Tagebücher 1914 – 1916), Culture & Value and his diaries of the 1930s (Denkbewegungen).

Finally, I will focus on Wittgenstein’s coded remarks (in the wartime notebooks and in his diaristic remarks found in the Nachlass) and then discuss their significance not only in terms of his personal attitude toward life, ethics and religion but also in terms of their role in the context of his philosophizing. In doing so, I will discuss the question of the extent to which Wittgenstein’s method of encoding can be seen as a means for a special type of text, conceived for a sphere not readily accessible to normal language and science – a sphere he avoided talking about in the context of strict philosophical dispute.