bluuebunny/crossref_metadata_2025 huggingface dataset:
Potential of Trilayered Gelatin/Polycaprolactone Nanofibers for Periodontal Regeneration: An In Vitro Study
Authors: Tian Zhiwei , Zhao Zhongqi , Rausch Marco Aoqi , Behm Christian , Tur Dino , Shokoohi-Tabrizi Hassan Ali , Andrukhov Oleh , Rausch-Fan Xiaohui
Published: January 2025

Over the past few years, biomaterial-based periodontal tissue engineering has gained popularity. An ideal biomaterial for treating periodontal defects is expected to stimulate periodontal-derived cells, allowing them to contribute most efficiently to tissue reconstruction. The present study focuses on evaluating the in vitro behavior of human periodontal ligament-derived stromal cells (hPDL-MSCs) when cultured on gelatin/Polycaprolactone prototype (GPP) and volume-stable collagen matrix (VSCM). Cells were cultured onto the GPP, VSCM, or tissue culture plate (TCP) for 3, 7, and 14 days. Cell morphology, adhesion, proliferation/viability, the gene expression of Collagen type I, alpha1 (COL1A1), Vascular endothelial growth factor A (VEGF-A), Periostin (POSTN), Cementum protein 1 (CEMP1), Cementum attachment protein (CAP), Interleukin 8 (IL-8) and Osteocalcin (OCN), and the levels of VEGF-A and IL-8 proteins were investigated. hPDL-MSCs attached to both biomaterials exhibited a different morphology compared to TCP. GPP exhibited stronger capabilities in enhancing cell viability and metabolic activity compared to VSCM. In most cases, the expression of all investigated genes, except POSTN, was stimulated by both materials, with GPP having a superior effect on COL1A1 and VEGF-A, and VSCM on OCN. The IL-8 protein production was slightly higher in cells grown on VSCM. GPP also exhibited the ability to absorb VEGF-A protein. The gene expression of POSTN was promoted by GPP and slightly suppressed by VSCM. In summary, our findings indicate that GPP electrospun nanofibers effectively promote the functional performance of PDLSCs in periodontal regeneration, particularly in the periodontal ligament and cementum compartment.
Genetic and Immunological Insights into Tick-Bite Hypersensitivity and Alpha-Gal Syndrome: A Case Study Approach
Authors: Banović Pavle , Jakimovski Dejan , Mijatović Dragana , Bogdan Ivana , Simin Verica , Grujić Jasmina , Vojvodić Svetlana , Vučković Nada , Lis Kinga , Meletis Eleftherios , Kostoulas Polychronis , Cvetkova Mladenovska Marija , Foucault-Simonin Angélique , Moutailler Sara , Mateos-Hernández Lourdes , Cabezas-Cruz Alejandro
Published: January 2025

Tick-bite hypersensitivity encompasses a range of clinical manifestations, from localized allergic reactions to systemic conditions like alpha-gal syndrome (AGS), an IgE-mediated allergy to galactose-α-1,3-galactose (α-Gal). This study investigated the clinical, molecular, immunological, and genetic features of two hypersensitivity cases. Two cases were analyzed: a 30-year-old woman with fixed drug reaction (FDR)-like hypersensitivity and a 10-year-old girl with AGS exhibiting borderline α-Gal-specific IgE. Diagnostic methods included allergen-specific IgE quantification, HLA genotyping, histopathological examination, and the molecular detection of tick-borne pathogens using microfluidic PCR. Case I demonstrated histopathological features of chronic lymphocytic inflammation and eosinophilic infiltrates, with HLA-B13 and DRB113 alleles indicating genetic susceptibility to hypersensitivity, while histological findings suggested a localized FDR-like reaction. Case II exhibited borderline α-Gal-specific IgE, resolving completely with a mammalian-free diet. The presence of HLA-DRB101 and DQB1*05 in the second patient indicated a genetic predisposition to AGS and other atopic conditions. No infectious etiology was identified in either case. These findings emphasize the heterogeneity of tick-related hypersensitivity and the importance of HLA genotypes in susceptibility. Comprehensive molecular, immunological, and genetic profiling offers valuable insights into the mechanisms of hypersensitivity, supporting personalized approaches for the diagnosis and management of tick-induced allergic conditions.
Olaparib Combined with DDR Inhibitors Effectively Prevents EMT and Affects miRNA Regulation in TP53-Mutated Epithelial Ovarian Cancer Cell Lines
Authors: Gralewska Patrycja , Biegała Łukasz , Gajek Arkadiusz , Szymczak-Pajor Izabela , Marczak Agnieszka , Śliwińska Agnieszka , Rogalska Aneta
Published: January 2025

Epithelial ovarian cancer (EOC) remains a leading cause of gynecologic cancer mortality. Despite advances in treatment, metastatic progression and resistance to standard therapies significantly worsen patient outcomes. Epithelial–mesenchymal transition (EMT) is a critical process in metastasis, enabling cancer cells to gain invasive and migratory capabilities, often driven by changing miRNA expression involved in the regulation of pathological processes like drug resistance. Targeted therapies like PARP inhibitors (PARPi) have improved outcomes, particularly in BRCA-mutated and DNA repair-deficient tumors; however, resistance and limited efficacy in advanced stages remain challenges. Recent studies highlight the potential synergy of PARPi with DNA damage response (DDR) inhibitors, such as ATR and CHK1 inhibitors, which disrupt cancer cell survival pathways under stress. This study investigated the combined effects of olaparib with ATR and CHK1 inhibitors (ATRi and CHK1i) on migration, invasion, and EMT-related protein expression and miRNA expression in ovarian cancer cell lines OV-90 and SKOV-3. The results demonstrated enhanced cytotoxicity, inhibition of migration and invasion, and modulation of miRNAs linked to metastasis. These findings suggest that combination therapies targeting DNA repair and cell cycle pathways may offer a novel, more effective approach to managing advanced EOC and reducing metastatic spread.
Biomedical Application of MSCs in Corneal Regeneration and Repair
Authors: De Miguel Maria P. , Cadenas-Martin Marta , Stokking Martha , Martin-Gonzalez Ana I.
Published: January 2025

The World Health Organization estimates that approximately 285 million people suffer from visual impairments, around 5% of which are caused by corneal pathologies. Currently, the most common clinical treatment consists of a corneal transplant (keratoplasty) from a human donor. However, worldwide demand for donor corneas amply exceeds the available supply. Lamellar keratoplasty (transplantation replacement of only one of the three layers of the cornea) is partially solving the problem of cornea undersupply. Obviously, cell therapy applied to every one of these layers will expand current therapeutic options, reducing the cost of ophthalmological interventions and increasing the effectiveness of surgery. Mesenchymal stem cells (MSCs) are adult stem cells with the capacity for self-renewal and differentiation into different cell lineages. They can be obtained from many human tissues, such as bone marrow, umbilical cord, adipose tissue, dental pulp, skin, and cornea. Their ease of collection and advantages over embryonic stem cells or induced pluripotent stem cells make them a very practical source for experimental and potential clinical applications. In this review, we focus on recent advances using MSCs from different sources to replace the damaged cells of the three corneal layers, at both the preclinical and clinical levels for specific corneal diseases.
Utilization of Cannabidiol in Post-Organ-Transplant Care
Authors: Koyama Sachiko , Etkins Jumar , Jun Joshua , Miller Matthew , So Gerald C. , Gisch Debora L. , Eadon Michael T.
Published: January 2025

Cannabidiol (CBD) is one of the major phytochemical constituents of cannabis, Cannabis sativa, widely recognized for its therapeutic potential. While cannabis has been utilized for medicinal purposes since ancient times, its psychoactive and addictive properties led to its prohibition in 1937, with only the medical use being reauthorized in 1998. Unlike tetrahydrocannabinol (THC), CBD lacks psychoactive and addictive properties, yet the name that suggests its association with cannabis has significantly contributed to its public visibility. CBD exhibits diverse pharmacological properties, most notably anti-inflammatory effects. Additionally, it interacts with key drug-metabolizing enzyme families, including cytochrome P450 (CYP) and uridine 5′-diphospho-glucuronosyltransferase (UGT), which mediate phase I and phase II metabolism, respectively. By binding to these enzymes, CBD can inhibit the metabolism of co-administered drugs, which can potentially enhance their toxicity or therapeutic effects. Mild to moderate adverse events associated with CBD use have been reported. Advances in chemical formulation techniques have recently enabled strategies to minimize these effects. This review provides an overview of CBD, covering its historical background, recent clinical trials, adverse event profiles, and interactions with molecular targets such as receptors, channels, and enzymes. We particularly emphasize the mechanisms underlying its anti-inflammatory effects and interaction with drugs relevant to organ transplantation. Finally, we explore recent progress in the chemical formulation of CBD in order to enhance its bioavailability, which will enable decreasing the dose to use and increase its safety and efficacy.
Identifying a Biocontrol Bacterium with Disease-Prevention Potential and Employing It as a Powerful Biocontrol Agent Against Fusarium oxysporum
Authors: Wang Qi , Sun Zhenshu , Li Tiantian , Fan Tiantian , Zhou Ziqi , Liu Jiayin , Chen Xiuling , Wang Aoxue
Published: January 2025

Biocontrol microbes are environment friendly and safe for humans and animals. To seek biocontrol microbes effective in suppressing Fusarium oxysporum is important for tomato production. F. oxysporum is a soil-borne pathogen capable of causing wilt in numerous plant species. Therefore, we found a biocontrol bacterium with an excellent control effect from the rhizosphere soil of plant roots. In this work, we focus on two parts of work. The first part is the identification and genomic analysis of the biocontrol bacterium Y-4; the second part is the control efficiency of strain Y-4 on F. oxysporum. For this study, we identified strain Y-4 as Bacillus velezensis. It is an aerobic Gram-positive bacterium that can secrete a variety of extracellular enzymes and siderophores. Strain Y-4 also contains a large number of disease-resistant genes and a gene cluster that forms antibacterial substances. In addition, we found that it significantly inhibited the reproduction of F. oxysporum in a culture dish. In the indoor control effect test, after treatment with strain Y-4 suspension, the disease index of tomato plants decreased significantly. Furthermore, the control efficiency of the plants was 71.88%. At the same time, Y-4 bacterial suspension induced an increase in POD and SOD enzyme activities in tomato leaves, resulting in increased plant resistance. Taken together, strain Y-4 proves to be an effective means of controlling F. oxysporum in tomatoes.
Acute Severe Hypoxia Decreases Mitochondrial Chain Complex II Respiration in Human Peripheral Blood Mononuclear Cells
Authors: Riou Marianne , Charles Anne-Laure , Enache Irina , Evrard Charles , Pistea Cristina , Giannini Margherita , Charloux Anne , Geny Bernard
Published: January 2025

Peripheral blood mononuclear cells’ (PBMCs) mitochondrial respiration is impaired and likely involved in myocardial injury and heart failure pathophysiology, but its response to acute and severe hypoxia, often associated with such diseases, is largely unknown in humans. We therefore determined the effects of acute hypoxia on PBMC mitochondrial respiration and ROS production in healthy volunteers exposed to controlled oxygen reduction, achieving an inspired oxygen fraction of 10.5%. We also investigated potential relationships with gene expression of key biomarkers of hypoxia, succinate and inflammation, as hypoxia and inflammation share common mechanisms involved in cardiovascular disease. Unlike global mitochondrial respiration, hypoxemia with a spO2 ≤ 80% significantly reduced PBMC complex II respiration (from 6.5 ± 1.2 to 3.1 ± 0.5 pmol/s/106 cell, p = 0.04). Complex II activity correlated positively with spO2 (r = 0.63, p = 0.02) and inversely correlated with the succinate receptor SUCNR1 (r = −0.68), the alpha-subunit of the hypoxia-inducible factor (HIF-1α, r = −0.61), the chemokine ligand-9 (r = −0.68) and interferon-stimulated gene 15 (r = −0.75). In conclusion, severe hypoxia specifically impairs complex II respiration in association with succinate, inflammation and HIF-1α pathway interactions in human PBMCs. These results support further studies investigating whether modulation of complex II activity might modify the inflammatory and metabolic alterations observed in heart failure.
Decoding Codon Bias: The Role of tRNA Modifications in Tissue-Specific Translation
Authors: Ando Daisuke , Rashad Sherif , Begley Thomas J. , Endo Hidenori , Aoki Masashi , Dedon Peter C. , Niizuma Kuniyasu
Published: January 2025

The tRNA epitranscriptome has been recognized as an important player in mRNA translation regulation. Our knowledge of the role of the tRNA epitranscriptome in fine-tuning translation via codon decoding at tissue or cell levels remains incomplete. We analyzed tRNA expression and modifications as well as codon optimality across seven mouse tissues. Our analysis revealed distinct enrichment patterns of tRNA modifications in different tissues. Queuosine (Q) tRNA modification was most enriched in the brain compared to other tissues, while mitochondrial tRNA modifications and tRNA expression were highest in the heart. Using this observation, we synthesized, and delivered in vivo, codon-mutated EGFP for Q-codons, where the C-ending Q-codons were replaced with U-ending codons. The protein levels of mutant EGFP were downregulated in liver, which is poor in Q, while in brain EGFP, levels did not change. These data show that understanding tRNA modification enrichments across tissues is not only essential for understanding codon decoding and bias but can also be utilized for optimizing gene and mRNA therapeutics to be more tissue-, cell-, or condition-specific.
The Thermal Tolerance of Springtails in a Tropical Cave, with the Description of a New Coecobrya Species (Collembola: Entomobryidae) from Thailand
Authors: Manee Nongnapat , Deharveng Louis , D’Haese Cyrille A. , Nilsai Areeruk , Shimano Satoshi , Jantarit Sopark
Published: January 2025

A new species of Collembola in the genus Coecobrya, C. microphthalma sp. nov., is described from a cave environment in Saraburi province, central Thailand. The new species is the second described species of the boneti-group found in the country. It is most similar to C. chompon Nilsai, Lima & Jantarit, 2022, which is also described from a Thai cave. However, the new species is morphologically different from C. chompon in having orange dot pigmentation on its body and a combination of other morphological characteristics such as the number of sublobal hairs on the maxillary outer lobe and the number of medio-sublateral mac on Th. II, Abd. I, Abd. III and Abd. IV and the anterior face of the ventral tube. The morphological comparison of all known boneti species and a key to the world species of Coecobrya of the boneti-group are given. Coecobrya microphthalma sp. nov. was successfully cultured in the laboratory. The thermal tolerance of the new species was studied and tested with seven different temperature experiments (27 °C as a control, 30, 32, 33, 34, 35 and 36 °C). The results showed that C. microphthalma sp. nov. cannot survive at a temperature higher than 32 °C after exposure to the experimental heat for 7 and 14 consecutive days. At 27, 30 and 32 °C, C. microphthalma sp. nov. remained alive and produced eggs, but the duration of egg production and number of egg-laying days significantly declined when the temperature increased (p < 0.001). An interesting aspect of their reproduction concerns temperature. At 32 °C (5 °C above the control temperature), the F1 generation survived, was active and was able to molt to the adult stage. However, specimens were unable to produce the next generation of offspring. For postembryonic development, C. microphthalma sp. nov. required six molts to reach the adult stage. The development rate (from egg to adult) varied and differed significantly between the tested temperatures (p < 0.001). An increase in temperature from the control temperature significantly accelerated the developmental rate from egg to juvenile instars to adult with a statistical significance (p < 0.01). This study is the first attempt that provide information on the impact of increasing temperature on the population dynamics, reproductive capacity and life history of a subterranean tropical Collembola.
Usefulness of Echocardiographic Parameters of Myocardial Work in Patients with Aortic Stenosis Undergoing Transcatheter Aortic Valve Implantation
Authors: Polewczyk Anna , Pietrzyk Edward , Polewczyk Maciej , Jarek Dariusz , Dudek Dariusz
Published: January 2025

Background: Myocardial work (MW) is a new echocardiographic parameter used in the assessment of cardiac energy expenditure. The aim of the current study was to evaluate changes in left ventricular MW parameters in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation (TAVI). Methods: One hundred and thirty five consecutive patients who underwent TAVI at one center were evaluated before and after the procedure using transthoracic echocardiography (TTE) to assess the following MW indices: global constructive work (GCW), global wasted work (GWW), global work index (GWI) and global work efficiency (GWE). Results: The comparison of MW parameters before and an average of 5.9 days after TAVI showed an increase in GCW, GWW and GWI, and no significant change in GWE. A detailed analysis showed an increase in GCW and GWI only in patients with the worst initial global longitudinal strain (GLS) > −8.0%: 845.2 vs. 852.2; p < 0.001 and 469.7 vs. 499.0 mmHg%; p < 0.001, respectively, whereas in the group of patients with GLS < −16.0%, a reduction in these indices was observed: 2135.8 vs. 2043.0; p < 0.001 and 1732.4 vs. 1633.1 mmHg%; p < 0.001. The significant increase in GWE was observed in patients with left ventricular ejection fraction (LVEF) < 30%: 77.7 vs. 72.0; p = 0.043 and GLS > −8.0%: 74.4 vs. 71.0 mmHg%; p < 0.001. The increase in GCW and GWI parameters after TAVI was strongly correlated with LVEF and pressure aortic gradient (PGA) before the procedure. Conclusions: Echocardiographic assessment of myocardial work parameters is a valuable method of documenting hemodynamic changes in patients with severe aortic stenosis before and after TAVI. Long-term left ventricular overload in patients with aortic stenosis results in a global reduction of myocardial work parameters; therefore, in patients with the lowest LVEF and GLS, the increased GCW, GWI and GWE reflect energy reserves enabling a rapid increase in the effective work of the heart.
Intimate Partner Violence: The Relationship Between the Stages of Change, Maintenance Factors, and the Decision to Keep or Leave the Violent Partner
Authors: Fávero Marisalva , Oliveira Rita , Del Campo Amaia , Fernandes Amadeu , Moreira Diana , Lanzarote-Fernández Maria Dolores , Sousa-Gomes Valéria
Published: January 2025

Objectives: Violence in intimate relationships (IPV) is understood as one of the most common forms of violence, being maintained by cultural habits and customs, and legitimized from generation to generation. This study aims at a comprehensive review of the literature on IPV, the relationship between the stages of change, maintenance factors, and the decision to keep or leave the violent partner. Methods: A comprehensive literature search was conducted to identify journal articles focused on IPV, following online databases as well as a manual review from relevant peer-reviewed journals. Results: Seeking help is one of the main steps in the process of change, and the stages of change are directly related to the success of interventions, so identifying stages early provides a more appropriate and effective choice of intervention. Conclusions: Thus, evaluating the stage of preparation for the change in which the victims are found is important for the individual understanding of the experience and supporting the intervention. In this sense, the Domestic Violence Survivor Assessment (DVSA) will also be presented, an instrument for evaluating the process of intentional change in victims of IPV, using the TTM.
Changes in the Microcirculation and Physiologic Perfusion Dynamics of Free DIEP Flaps in the First 72 h After Breast Reconstruction
Authors: Ehrl Denis , Alt Verena , Taha Sara , Frank Konstantin , Wachtel Nikolaus , Bodenschatz Karl J. , Demmer Wolfram , Fuchs Benedikt , Giunta Riccardo E. , Moellhoff Nicholas
Published: January 2025

Background/Objectives: The autologous reconstruction of the female breast using a microsurgical DIEP flap is a reliable and safe method. To detect impairments early and preserve the microvascular flap through timely revision, a better understanding of physiologic perfusion dynamics is necessary. This exploratory study examines changes in microcirculation in free DIEP flaps within the first 72 h after vascular anastomosis using laser Doppler flowmetry and white-light spectrophotometry. Methods: This single-center study analyzed retro- and prospectively collected data from female patients who underwent uneventful breast reconstruction using a DIEP flap and were monitored using the O2C device (LEA Medizintechnik, Giessen, Germany). Microcirculation was monitored continuously postoperatively for a period of 72 h. Results: A total of 36 patients with a mean age of 48.86 (9.36) years and a mean BMI of 26.78 (4.12) kg/m2 received 40 DIEP flaps (four bilateral reconstructions). Microcirculatory blood flow showed a continuous increase, reaching up to 15% above its initial value within the first 72 h following anastomosis. The average tissue oxygen saturation (sO2) and relative hemoglobin (rHB) levels remained fairly stable throughout the study period, with overall reductions of 5.46% and 5.30%, respectively. Conclusions: Autologous breast reconstruction using a microvascular DIEP flap is a safe and reliable technique. This study showed an increase in blood flow over the 72 h study period. At the same time, sO2 and rHb showed stable levels. Deviations in these values could be interpreted as indicators of a perfusion disorder of the microvascular flap.
Assessment of Long-Term Engagement in Aerobic Versus Resistance Exercise on 20-Year Cardiovascular Disease Incidence (2002–2024): The ATTICA Epidemiological Cohort Study
Authors: Dimitriadis Nikos , Arnaoutis Giannis , Chrysohoou Christina , Barkas Fotios , Liberopoulos Evangelos , Sfikakis Petros P. , Pitsavos Christos , Tsioufis Costas , Tambalis Konstantinos D. , Panagiotakos Demosthenes
Published: January 2025

Objective: The aim of this study was to assess whether aerobic exercise, as opposed to resistance training or a combination of both, is associated with long-term cardiovascular outcomes. Methods: The ATTICA study is a population-based cohort study with a 20-year follow-up (2002–2022); it was conducted in the Attica region, Greece, and included 3042 adult participants (45 ± 11 years, 1518 females). Physical activity engagement in aerobic, resistance, or combined exercise, and 20-year tracking, together with information regarding atherosclerotic cardiovascular disease (ASCVD) incidence were available for 1988 participants (45 ± 12 years old, 987 males, 1001 females). Physical activity levels were evaluated using the validated International Physical Activity Questionnaire, in all follow-up examinations (2001–2002, 2006, 2012, and 2022). Cox proportional hazard models were applied; the results are presented as hazard ratio (HR) and 95% confidence intervals (CIs). Results: Participants engaged in the combined (aerobic and resistance) physical activity group had 0.41-times [95%CI (0.20, 0.82)] lower ASCVD risk compared to inactive participants; participants in the healthy engaging aerobic physical activity (HEPA) group had 0.54-times [95%CI (0.36, 0.80)] lower ASCVD risk; no significant associations were observed regarding the minimally active aerobic group [HR, 0.81, 95%CI (0.57, 1.17)], or the resistance training only group [HR, 1.17, 95%CI (0.25, 1.52)]. Conclusions: These findings carry a strong public health message, underscoring the importance of incorporating aerobic or combined aerobic–resistance training into physical activity guidelines to enhance cardiovascular health and reduce the long-term risk of CVD.
Genetic Risk Profiling Reveals Altered Glycosyltransferase Expression as a Predictor for Patient Outcome in Neuroblastoma
Authors: Bley Isabelle Ariane , Behrens Stefan , Spohn Michael , Müller Ingo , Schattling Benjamin
Published: January 2025

Background/Objectives: Neuroblastoma is a highly aggressive pediatric cancer that arises from immature nerve cells and exhibits a broad spectrum of clinical presentations. While low- and intermediate-risk neuroblastomas often have favorable outcomes, high-risk neuroblastomas are associated with poor prognosis and significant treatment challenges. The complex genetic networks driving these high-risk cases remain poorly understood. This study aims to investigate differences in gene expression patterns that may contribute to disease outcomes. Methods: We employed an in silico approach to analyze a cohort of 493 neuroblastoma tumor samples that underwent mRNA sequencing (GSE49711). This dataset was reanalyzed in depth with a non-hypothesis-driven approach to identify the expression patterns and regulatory mechanisms associated with a poor prognosis. Results: By exploring global gene expression and the integration of clinical parameters, we stratified the samples into two groups with highly distinct gene expression profiles. MYCN amplification emerged as a major driver not only of poor prognosis but also of specific gene regulatory patterns. Notably, tumors with MYCN amplification exhibited the strong regulation of immune response genes and less immune infiltration, suggesting potential immune evasion. However, while we observed only minor changes in immune checkpoint expression, there was a strong modulation of glycosyltransferase genes in MYCN-amplified tumors. Using this information, we were able to construct a risk profile based on 12 glycosylation-related genes, which correlates with the survival outcomes of neuroblastoma patients. Conclusions: This study highlights the role of MYCN amplification in driving a poor prognosis in neuroblastoma through the regulation of immune response and glycosylation-related genes. Based on this finding, we developed a genetic risk profile that correlates with survival outcomes in neuroblastoma patients.
Review of Bioinspired Composites for Thermal Energy Storage: Preparation, Microstructures and Properties
Authors: Yu Min , Wang Mengyuan , Xu Changhao , Zhong Wei , Wu Haoqi , Lei Peng , Huang Zeya , Fu Renli , Gucci Francesco , Zhang Dou
Published: January 2025

Bioinspired composites for thermal energy storage have gained much attention all over the world. Bioinspired structures have several advantages as the skeleton for preparing thermal energy storage materials, including preventing leakage and improving thermal conductivity. Phase change materials (PCMs) play an important role in the development of energy storage materials because of their stable chemical/thermal properties and high latent heat storage capacity. However, their applications have been compromised, owing to low thermal conductivity and leakage. The plant-derived scaffolds (i.e., wood-derived SiC/Carbon) in the composites can not only provide higher thermal conductivity but also prevent leakage. In this paper, we review recent progress in the preparation, microstructures, properties and applications of bioinspired composites for thermal energy storage. Two methods are generally used for producing bioinspired composites, including the direct introduction of biomass-derived templates and the imitation of biological structures templates. Some of the key technologies for introducing PCMs into templates involves melting, vacuum impregnation, physical mixing, etc. Continuous and orderly channels inside the skeleton can improve the overall thermal conductivity, and the thermal conductivity of composites with biomass-derived, porous, silicon carbide skeleton can reach as high as 116 W/m*K. In addition, the tightly aligned microporous structure can cover the PCM well, resulting in good leakage resistance after up to 2500 hot and cold cycles. Currently, bioinspired composites for thermal energy storage hold the greatest promise for large-scale applications in the fields of building energy conservation and solar energy conversion/storage. This review provides guidance on the preparation methods, performance improvements and applications for the future research strategies of bioinspired composites for thermal energy storage.
An End-to-End Ocean Environmental Noise Anomaly Detection Framework Combining Time–Frequency Information and Expert Gating
Authors: Du Libin , Liu Mingyang , Lv Zhichao , Tan Chuanhe , He Junkai , Yu Fei
Published: January 2025

The detection and optimization of ocean environmental noise anomalies play a crucial role in enhancing the safety of marine engineering applications and ecological protection. Current anomaly detection methods for ocean environmental noise often suffer from issues of accuracy and robustness. To address these challenges, this paper first proposes an end-to-end framework that combines time–frequency information and expert gating, significantly improving the precision of noise sequence generation. Secondly, a Gamma distribution-based residual analysis method for anomaly detection is designed, enhancing the robustness of anomaly detection. Finally, an anomaly optimization module is developed to improve data quality, enabling efficient noise anomaly detection and optimization. Our experimental results demonstrate that the proposed model significantly outperforms traditional models in multi-frequency noise prediction, with strong robustness in anomaly detection and high generalization performance. The proposed framework offers a novel approach for analyzing the causes of noise anomalies and optimizing models. Additionally, the research outcomes provide efficient technical support for deep-sea exploration, equipment optimization, and environmental protection.
Numerical Simulation Study on Hydrodynamic Characteristics of Offshore Floating Photovoltaics
Authors: Sui Shuting , Cao Lu , Gao Yun , Huo Zhongyan , Chen Qi
Published: January 2025

With the development of renewable energy and the utilization of marine resources, large-scale offshore floating photovoltaics have gradually attracted widespread attention. In order to develop offshore floating photovoltaics and promote sustainable development, it has become necessary to explore the hydrodynamic characteristics of floating photovoltaic units and floating arrays. In this work, based on the viscous flow theory, the Computational Fluid Dynamics (CFD) and the discrete element method (DEM) methods are used to analyze the hydrodynamics of the floating body unit of offshore floating photovoltaics. The influencing factors include mooring length, mooring radius, and floating unit length. In addition, the hydrodynamic performance of the floating body unit and the floating body array under different wave heights and periods is also discussed to explore the influence of environmental loads on the floating body unit and the floating body array. The results indicate that the mooring tension exhibits an opposite trend with the surge and heave motions when the mooring line length and radius are varied. The motion is found to be more pronounced when the floating body unit length is 0.4 times the wavelength. The heave motion of the floating body unit exhibits a strong linear relationship with wave height, increasing by 0.01 m for every 0.015 m increase in wave height. The motion of the floating body units on both sides connected to the mooring lines decreases as the array length increases.
Response of Hard-Bottom Macro-Zoobenthos to the Transition of a Mediterranean Mariculture Fish Plant (Mar Grande of Taranto, Ionian Sea) into an Integrated Multi-Trophic Aquaculture (IMTA) System
Authors: Trani Roberta , Pierri Cataldo , Schiavo Antonella , Lazic Tamara , Mercurio Maria , Coccia Isabella , Giangrande Adriana , Longo Caterina
Published: January 2025

This study investigates the effects on hard-bottom macro-zoobenthic communities of converting a mariculture plant into an Integrated Multi-Trophic Aquaculture (IMTA) system. This study was conducted from 2018 to 2021 in the semi-enclosed Mar Grande basin of Taranto (northern Ionian Sea), on a facility located 600 m off the coastline, with a production capacity of 100 tons per year of seabass (Dicentrarchus labrax) and seabream (Sparus aurata). The results from seasonal sampling performed in a treatment site, where bioremediators (filter-feeding invertebrates such as sponges, polychaetes, mussels, and macroalgae) were deployed, and a control site without bioremediators were compared. Before the IMTA installation, the hard substrates under the cages were sparsely inhabited, with significant sediment coverage. By 2021, the treatment site exhibited revitalized and more diverse macro-zoobenthic communities, with species richness increasing from 83 taxa in 2018 to 104 taxa, including notable growth in sponges, annelids, mollusks, and bryozoans. In contrast, the control site showed no substantial changes in biodiversity over the same period. Biodiversity indices, including Shannon and Margalef indices, improved significantly at the treatment site, particularly during summer months, highlighting a more resilient and balanced benthic environment. Taxonomic distinctness (delta+) and multivariate analyses (PERMANOVA, PCO) confirmed significant spatial and temporal shifts in community structure at the treatment site, driven by IMTA implementation. SIMPER analysis identified key taxa contributing to these changes, which played a pivotal role in structuring the community. The emergence of filter feeders, predators, and omnivores at the treatment site suggests enhanced nutrient cycling and trophic complexity, while the decline in opportunistic species further supports improved environmental conditions. These findings demonstrate the potential of IMTA to promote recovery and sustainable mariculture practices, also offering a comprehensive understanding of its positive effects on hard-bottom benthic community dynamics.
Numerical Research on Hull–Propeller–Rudder–Ice Interaction of Full-Scale Polar Transport Ship in Brash Ice Channel
Authors: Zhang Jinlong , Zhang Jianing , Zhang Lei , Chen Weimin , Zhang Qingshan
Published: January 2025

A strong nonlinear ice load has a significant impact on the resistance and power demand of polar transport ships under different drafts in brash ice channels. In this study, the CFD-DEM coupling method is used to investigate the self-propulsion performance of a full-scale polar transport ship in brash ice channels. The interactions between the full-scale polar transport ship, propeller, rudder, and brash ice are effectively simulated. First, the hydrodynamic performance of an open-water propeller is tested, and it is found that the numerical errors of efficiency and the experimental result are less than 8%. Then, the ice resistance, total thrust, effective power, delivered power, and propulsive efficiency of the polar transport ship under different draft conditions are studied, and the results are in good agreement with those of the self-propulsion model tests in the brash ice channel. Through a numerical simulation of self-propulsion in the brash ice channel, self-propulsion points under different drafts and brash ice thicknesses are obtained. It is found that the propeller rotation speed is closely related to the draft depth. Finally, experiments and numerical simulations of the total ice resistance are carried out under different brash ice thicknesses, and the results are consistent with those of the empirical formulas. The accuracy of the three empirical formulas under different drafts is compared. This research work determines the resistance, power demand, and propulsive efficiency of a polar transport ship under given ice conditions and speeds, as well as the self-propulsion points under different ice thicknesses. It is of great significance for the control of ships in polar navigation.
Assessing Basel Capital Regulations: Exploring the Risk and Efficiency Relationship in Emerging Economies
Authors: Bashir Adnan , Salman Asma , Itani Rania , Faccia Alessio
Published: January 2025

This research investigates the relationship between Basel capital regulations, bank risk, and bank efficiency in the context of Pakistani and Indian commercial banks. This study examines the period from 2009 to 2022 and specifically analyses the impact of Basel III capital requirements on risk and efficiency. Quantitative methods are employed, utilising data from central bank websites and the BankScope database to construct a comprehensive sample of commercial banks in Pakistan and India. The system-generalised method of moments (GMM) estimation technique addresses potential endogeneity issues in the regression models. The findings shed light on the effectiveness of these regulations and provide insights for policymakers and regulators in both countries. The results indicate that Basel capital regulations have generally increased banks’ risk-taking behaviour in Pakistan and India. However, they have not improved the overall efficiency of the banking sector in either country. Bank efficiency declined during the study period, highlighting the limited effectiveness of Basel capital regulations in enhancing efficiency. Furthermore, the impact of these regulations on risk and efficiency varies between the two countries. In Pakistan, the regulations do not significantly affect bank efficiency, while in India, they decrease efficiency. Additionally, Basel III capital regulations do not significantly impact the risk taken by banks in either country. This study concludes by emphasising the need for alternative mechanisms or policies to improve the banking industry’s efficiency, as Basel capital regulations alone have proven ineffective. The findings offer valuable insights for central banks and regulators in assessing the relationship between capital regulations, risk, and efficiency and implementing appropriate measures to enhance the performance of the banking sector. This study recommends the following key points: the adoption of tailored regulatory approaches to address specific challenges, achieving an optimal balance between risk management and operational efficiency, enhancing the effectiveness of management roles, considering the influence of macroeconomic factors, and evaluating the implications of long-term policy development for sustainable progress. The present study adds to the prevalent literature on the impact of capital regulations on bank risk and efficiency nexus. This study focuses on Pakistan and India, which are two important developing nations. Moreover, another important contribution of this study lies in the effect of Basel III capital regulation on bank risk, as these capital regulations are different from other Basel capital requirements.
Vegetation Quality Assessment of the Shaanxi Section of the Yellow River Basin Based on NDVI and Rain-Use Efficiency
Authors: Liu Zhao , Wang Danyue , Han Lei , Kang Hongliang , Cao Xinxin
Published: January 2025

The Yellow River Basin is a critical region for ecological environment protection and social and economic development in China. It is of great significance to study vegetation dynamics for the high-quality development of the Yellow River Basin. In this study, based on the data of NDVI and precipitation datasets in the growing season (June to September) from 2000 to 2019, we used a Sen+Mann–Kendall trend analysis and other methods to study the spatial and temporal evolution characteristics of precipitation and vegetation cover in the Shaanxi section of the Yellow River Basin and to assess the regional vegetation quality change characteristics based on estimating the rain-use efficiency (RUE). The results show the following: (1) The precipitation in the study area showed a spatial distribution pattern of more in the south and less in the north, in which Yulin City had the lowest precipitation overall, but it was an area with significant increasing precipitation. (2) The NDVI value of the Shaanxi section of the Yellow River Basin showed an overall upward trend from 2000 to 2019, with a growth rate of 0.327/10a. The vegetation cover showed the spatial characteristics of high in the south and low in the north, which showed that the vegetation growth condition was poor in the wind-sand grassland area at the southern edge of the Mu Us Sandland in the northwestern part of Yulin City and the construction areas in the Guanzhong Plain. Meanwhile, the vegetation grew well in Yan’an City and the area close to the Qinba Mountains. Moreover, the NDVI of the study area increased with the increase in precipitation. (3) The vegetation quality in the study area showed fluctuating interannual changes and a weak upward trend. More than 80% of the vegetation in the study area was in a state of improvement, and the areas with more significant improvement were mainly located in the northern part of the study area, while the vegetation was degraded in the urban and urban suburb areas in the Guanzhong Plain. The results of this study are of great practical significance for promoting the socio-economic development of the Yellow River Basin in coordination with ecological environmental protection.
The Impact of Innovative City Pilot Policy on Urban Land Green Use Efficiency: A Quasi-Natural Experiment from China
Authors: Xu Hengzhou , Li Zhongyue , Guo Luyu , Liu Yingfei
Published: January 2025

China’s rapid urbanization has spurred significant economic growth, but it has also given rise to challenges such as urban sprawl, ecological degradation, and inefficient land use—issues that impede progress toward green and sustainable development. Land is the spatial foundation for green development, and promoting its green utilization is essential for advancing the high-quality development of urban spaces. As a concrete implementation of the innovation-driven development strategy, the National Innovative City Pilot Policy (NICPP) serves as a crucial driver in fostering high-quality development. In this context, the NICPP and green land use can be seen as two complementary components of achieving high-quality development. This study uses panel data from 266 cities across China and applies a difference-in-differences (DID) model to evaluate the effect of the NICPP on urban land green use efficiency (ULGUE), exploring the underlying mechanisms through the lenses of industrial structure and technological innovation. The results indicate that the NICPP significantly and robustly enhances ULGUE. The effect varies geographically and by city type, with the most pronounced benefits observed in eastern cities, non-resource-based cities, and non-old industrial base cities. Additionally, the NICPP contributes to improved comprehensive output benefits during land use activities and reduced pollutant emissions by optimizing industrial structures and enhancing technological innovation capacity, thereby promoting ULGUE. Therefore, in the future, the focus should be on integrating innovation with strategic policies. These findings carry profound implications for urban development in China and provide important lessons for promoting sustainable urban growth on a global scale.
Integrated Machine Learning Approaches for Landslide Susceptibility Mapping Along the Pakistan–China Karakoram Highway
Authors: Ullah Mohib , Qiu Haijun , Huangfu Wenchao , Yang Dongdong , Wei Yingdong , Tang Bingzhe
Published: January 2025

The effectiveness of data-driven landslide susceptibility mapping relies on data integrity and advanced geospatial analysis; however, selecting the most suitable method and identifying key regional factors remains a challenging task. To address this, this study assessed the performance of six machine learning models, including Convolutional Neural Networks (CNNs), Random Forest (RF), Categorical Boosting (CatBoost), their CNN-based hybrid models (CNN+RF and CNN+CatBoost), and a Stacking Ensemble (SE) combining CNN, RF, and CatBoost in mapping landslide susceptibility along the Karakoram Highway in northern Pakistan. Twelve geospatial factors were examined, categorized into Topography/Geomorphology, Land Cover/Vegetation, Geology, Hydrology, and Anthropogenic Influence. A detailed landslide inventory of 272 occurrences was compiled to train the models. The proposed stacking ensemble and hybrid models improve landslide susceptibility modeling, with the stacking ensemble achieving an AUC of 0.91. Hybrid modeling enhances accuracy, with CNN–RF boosting RF’s AUC from 0.85 to 0.89 and CNN–CatBoost increasing CatBoost’s AUC from 0.87 to 0.90. Chi-square (χ2) values (9.8–21.2) and p-values (<0.005) confirm statistical significance across models. This study identifies approximately 20.70% of the area as from high to very high risk, with the SE model excelling in detecting high-risk zones. Key factors influencing landslide susceptibility showed slight variations across the models, while multicollinearity among variables remained minimal. The proposed modeling approach reduces uncertainties, enhances prediction accuracy, and supports decision-makers in implementing effective landslide mitigation strategies.
An Acoustic Study of Romanian Stressed Vowels with Special Reference to Mid Central [ɨ] and [ə]
Authors: Recasens Daniel , Sánchez-Miret Fernando
Published: January 2025

The present study is concerned with some aspects of the production of [ɨ] and [ə] in Romanian, i.e., their position within the vowel space, degree of acoustic variability and acoustic duration. To this end, acoustic data were collected for the Romanian stressed vowels [i e a o u ɨ ə] produced by six speakers in controlled consonantal context conditions and real and nonsense words. The formant frequency data reveal that [ɨ] and [ə] do not overlap along the F1 dimension, which may be ascribed to the need to set in contrast the two central vowels phonologically. Moreover, [ɨ] is clearly more variable in F2, and thus in vowel fronting, than schwa. Regarding segmental duration, [ɨ] is as short as high vowels and shorter than schwa, whose duration is comparable to that of mid vowels. The phonetic characteristics for stressed schwa in Romanian are in contrast with those for the same vowel in other world’s languages, in which it is highly variable and shorter than all or most peripheral vowels. This behaviour may be attributed to the existence of two central vowels, while suggesting that [ə] has a well-defined articulatory target in the Romanian language.