bluuebunny/crossref_metadata_2025 huggingface dataset:
Body image discontentment among head and neck cancer patients in Visakhapatnam district: An empirical study
Authors: Neba Precedis Mankaah
Published: September 2024

Head and neck cancers, which comprise tumours of the oral cavity, throat, nasal cavity, and thyroid, pose substantial physical and psychological issues. These tumours frequently require harsh therapies such as surgery, radiation therapy, and chemotherapy, which can result in apparent changes in appearance and physical function. As a result, patients are frequently subjected to body image distress, low self-esteem, and overall unhealthy psychological well-being. This study aims to investigate head and neck cancer patients' self-perceptions and body image problems, with an emphasis on feelings of self-consciousness, physical attractiveness, and general body dissatisfaction amongst head and neck cancer out patients undergoing treatment in HCG cancer hospital in Visakhapatnam. This study was conducted on 50 head and neck cancer outpatients undergoing treatment at an oncology centre Healthcare Global Enterprises ltd (HCG) hospital Visakhapatnam during the period of (May 2023 to June 2023) who were willing to participate in the study and were 20 years of age and above. An interview schedule was prepared by the researcher and administered to the patients comprising section A (questions pertaining to the demographic and clinical details of the patient), section B (modified 6 item Body Image Scale). Majority of the patients were male (62%) while female constituted 38% with the majority aged between 20- 39 years (61%) and the most common cancer being that of oral cavity (58%). The findings reveal a sizable proportion of respondents reporting feeling self-conscious and less physically attractive as a result of their sickness or treatment. Many individuals are dissatisfied with their appearance and overall body image, with a significant percentage reporting that these issues interfere with their social relationships and sense of wholeness. These findings highlight the need of addressing psychological and emotional support in the treatment and care of head and neck cancer patients. Integrating mental health and body image counselling into cancer treatment programmes has the potential to greatly improve patients' overall well-being and quality of life.
Análise da Variabilidade Acoplada Oceano-Atmosfera: Oscilação de Madden-Julian, La Niña, e Ondas de Instabilidade Tropical – Um estudo de caso da atividade convectiva sobre o Estado do Ceará durante o ano de 2010
Authors: Ferreira Jose Mauricio da Silva , Barbosa Augusto César Barros , Brandão Matheus Dos Reis , Silva Francisca Alana Nascimento da , Silva Timóteo Lopes Carneiro da , Garcia Brendo Rodrigues
Published: September 2024

A interação oceano-atmosfera e a variabilidade climática global têm sido amplamente estudadas. Este trabalho investiga o impacto das mudanças atmosféricas no total pluviométrico do Nordeste do Brasil, focando no Ceará. Fenômenos como a Oscilação de Madden-Julian (OMJ), La Niña e as Ondas de Instabilidade Tropical (OIT) podem influenciar a atividade convectiva na região. O objetivo deste estudo foi analisar, através da variabilidade espectral obtida com a Transformada em Ondaletas (Morlet), o acoplamento energético intrassazonal (20-70 dias) entre a OMJ e às OIT durante um período de forte La Niña, e seu impacto na precipitação no Ceará. O período estudado foi de junho a outubro de 2010, quando a Zona de Convergência Intertropical (ZCIT) não influencia diretamente nas chuvas no Nordeste. Nesse período, um evento extremo da OMJ em 28.09.2010 teve uma resposta remota no Ceará em 23.10.2010, e foi observado aumento da atividade intrassazonal das OIT no Atlântico tropical em 1⁰N21⁰W. Os resultados mostraram que aproximadamente 80% da energia espectral intrassazonal gerada pela OMJ na região do Oceano Índico chegou ao Ceará, provocando forte atividade convectiva e altos índices pluviométricos. A conservação dessa energia pode ser explicada pelo estado básico da atmosfera, favorecido pela forte La Niña entre setembro e outubro. Conclui-se que a interação entre o Oceano Índico e o Ceará, e entre o Ceará e as OIT (1⁰N21⁰W), ocorre na escala de 24 dias, com transferência de energia da escala de 32 dias para a de 24 dias, resultando em altos índices de chuva em várias regiões do Ceará.
Panorama dos transtornos alimentares a partir do questionário Eating Attitudes Test (EAT-26)
Authors: Santos Maria Fernanda Santa Rosa , Tamelini Sthefani Lima , Azevedo Otávio David Damasceno de , Santos João Pedro Santa Rosa , Miranda Lidiane Paula Ardisson
Published: September 2024

Introdução: O Transtorno Alimentar (TA) tem se revelado um problema persistente tanto no país quanto globalmente. Essa condição psiquiátrica é caracterizada por padrões persistentes e anormais de alimentação ou comportamento alimentar. Assim, o TA leva a um consumo inadequado e/ou má absorção de nutrientes, afetando de maneira significativa a saúde mental, física, nutricional e social do indivíduo. Objetivo: Avaliar o cenário recente do TA e o uso do EAT-26. Metodologia: A pesquisa foi realizada em julho de 2024, foram encontrados 26 artigos nas bases de dados, sendo selecionados 11. Resultado: A partir dos resultados encontrados, foi possível observar que a incidência de TA é maior no sexo feminino jovem. Além disso, os estudos mostraram maior prevalência entre estudantes da área da saúde, e a maior parte desses estudos foram realizados no Oriente Médio. Conclusão: A utilização do questionário EAT-26 tem se revelado eficaz na identificação dos transtornos alimentares. Assim, pode-se concluir que o transtorno alimentar é uma questão importante. A adoção de intervenções que abordem a origem do problema é crucial, levando em conta fatores como gênero, índice de massa corporal (IMC) e o ambiente acadêmico com elevado nível de estresse.
Enxerto ósseo guiado para mandíbula atrófica
Authors: Silva Gledson Cordeiro da , Meira Carlos Eduardo
Published: September 2024

O enxerto ósseo guiado para mandíbula atrófica é uma técnica avançada utilizada para reconstruir e restaurar a estrutura óssea em mandíbulas que sofreram perda significativa de massa óssea. Esta abordagem é especialmente indicada para pacientes que necessitam de implantes dentários, mas cuja estrutura óssea não é adequada para suportá-los. O procedimento envolve a utilização de materiais de enxerto ósseo que são colocados na área afetada, com o objetivo de estimular a formação de novo osso. O uso de membranas de barreira pode ser incorporado para guiar o crescimento ósseo e evitar a invasão de tecidos moles indesejados. O enxerto pode ser realizado utilizando ossos autólogos, alógenos ou sintéticos, dependendo das necessidades específicas do paciente e da condição da mandíbula. A técnica proporciona uma base sólida e estável para futuros implantes dentários, melhorando significativamente a funcionalidade e a estética oral do paciente. O sucesso do procedimento depende de uma avaliação prévia adequada, planejamento cirúrgico minucioso e cuidados pós-operatórios rigorosos para garantir a integração eficaz do enxerto com o osso existente. Assim, essa revisão narrativa da literatura tem como objetivo analisar as publicações acerca do enxerto ósseo guiado para mandíbula atrófica.
Transformações qualitativas e quantitativas dos parâmetros físico-químicos em cachaças envelhecidas
Authors: Santiago Marcos Aurélio Araújo , Santiago Wilder Douglas , Fernandes Antonia Isadora , Teixeira Maria Luísa , Silva Sara Cristina Santos , Rezende Danúbia Aparecida Carvalho Selvati , Cardoso Maria das Graças
Published: September 2024

A cachaça vem sendo envelhecida em barris de diferentes madeiras a fim de proporcionar, não só um valor agregado ao produto, mas também experiências organolépticas únicas a seus consumidores. Este processo de envelhecimento possui várias nuances singulares que tornam cada produto único e essas podem estar relacionadas com a espécie da madeira, o corte usado para confecção dos barris, temperatura e umidade no local de envelhecimento, tempo de envelhecimento, entre outros. Apesar do processo apresentar muitas variáveis, é possível determinar as principais reações de transformação que ocorrem durante esta etapa do processo produtivo. O objetivo do trabalho foi fazer uma avaliação qualitativa e quantitativa dos compostos presentes em diferentes amostras de cachaças envelhecidas, a fim de melhor entender as transformações que ocorrem durante o período de envelhecimento. As cachaças em estudo apresentaram diferenciação na composição química, fato já esperado, visto que o processo de envelhecimento tende a agregar compostos que apresentam modificações, nas bebidas, quanto a suas características organolépticas. Vale destacar que todas as amostras atendem a legislação vigente quanto aos seus parâmetros analisados. As bebidas apresentaram valores distintos nos compostos fenólicos analisados, tanto em termos de concentração e identificação. A cachaça envelhecida em carvalho apresentou o siringaldeído (1,66 mg L-1) como compostos majoritário, a amburana a cumarina (4,52 mg L-1), jequitibá a vanilina (0,12 mg L-1) e o blend carvalho/castanheira o ácido gálico (1,24 mg L-1) e siringaldeído (2,08 mg L-1). Assim, pode-se inferir que esses compostos majoritários encontrados são possíveis marcadores químicos para essas madeiras em estudo.
Efeitos hemodinâmicos da administração de sulfato de magnésio na indução anestésica durante a laringoscopia e intubação orotraqueal: Um ensaio clínico randomizado
Authors: Silva Michelly Gomes da , Rocha Neto Aguinaldo Freire , Sena Jessica Suelen , Ribeiro Saula Maria de Lira , Barros Lucas Soares Brandão , Sousa Maria Clara Oliveira Campos , Epitácio Bruno de Castro Fernandes
Published: September 2024

A resposta hemodinâmica aos estímulos da laringoscopia e intubação orotraqueal, especialmente hipertensão e taquicardia, é um fenômeno comum, o controle desse reflexo indesejado é parte fundamental do manejo anestésico. Nessa perspectiva, o presente estudo teve como objetivo analisar os efeitos hemodinâmicos da administração de sulfato de magnésio na indução anestésica durante a laringoscopia e intubação orotraqueal. Trata-se de um ensaio clínico randomizado, controlado, simples-cego, prospectivo e unicêntrico, realizado em um Hospital Universitário de uma capital da região Nordeste, foram avaliados 40 pacientes, que seriam submetidos à intubação orotraqueal após a indução para anestesia geral, que foram divididos em dois grupos, Grupo 1: sulfato de magnésio a 10%, e Grupo 2: solução salina 0,9% simples.  Foram incluídos pacientes entre 18 e 59 anos, escalados para cirurgias eletivas sob anestesia geral com intubação orotraqueal, classificados como ASA I ou II. Dentre os participantes da pesquisa houve prevalência de indivíduos com 46-59 anos (32,5%), do sexo feminino (67,5%), classificados no grau ASA I (60%) e provenientes de Teresina (62,5%). Com relação aos parâmetros fisiológicos avaliados, verificou-se que os indivíduos do Grupo 1, apresentaram menores médias quando comparados a amostra total e Grupo 2. Os resultados deste estudo apontam que a administração de sulfato de magnésio a 10%, durante a realização do procedimento de laringoscopia e intubação orotraqueal pode ser uma alternativa adequada. A administração de sulfato de magnésio pode ser um método eficaz e seguro, sem alterações hemodinâmicas aparentes.
Estudo epidemiológico da correlação entre fatores sociodemográficos e adesão à vacinação contra a COVID-19 na macrorregião Sul de Minas Gerais
Authors: Rodrigues Bárbara Ferreira , Vieira Mateus Freire , Barros Gérsika Bitencourt Santos
Published: September 2024

A pandemia da COVID-19 trouxe grandes impactos para a saúde pública. O presente estudo tem como objetivo analisar o perfil sociodemográfico da população aderente à vacinação contra a COVID-19, na macrorregião Sul, de Minas Gerais, e caracterizar os fatores que influenciaram para essa adesão. Para isso, foram utilizados os dados disponibilizados pelo IBGE Cidades e pelo Boletim Epidemiológico Coronavírus da Secretaria de Estado de Saúde de Minas Gerais. Em seguida, realizou-se análise de componentes principais seguida de regressão linear múltipla para avaliar os efeitos das variáveis sociais, econômicas e de saúde no comportamento espacial da cobertura vacinal, considerando primeira (d1), segunda e dose única (d2_du). Com isso, foram definidas as variáveis que exerceram influência diretamente e inversamente proporcional sobre a adesão à vacinação. Dessa forma, observou-se que o número de estabelecimentos de ensino fundamental e médio (var_escolar) e o PIB per capita apresentam correlação positiva com d1, enquanto salário médio mensal dos trabalhadores formais apresenta correlação negativa. Já o comportamento espacial de d2_du é explicado positivamente por d1 e var_escolar. Por fim, concluiu-se que os fatores sociodemográficos exerceram grande influência sobre a adesão da população em estudo à vacinação contra a COVID-19.
Internações por Condições Sensíveis à Atenção Primária (ICSAP), entre 2008 e 2023, no estado de São Paulo
Authors: Rubim Larissa Daniele , Bastos Tassia Fraga , Gomes Marcos Costa Naves , Almeida Gabrielle Oliveira
Published: September 2024

As Internações por Condições Sensíveis à Atenção Primária (ICSAP) têm sido utilizadas como indicador indireto da qualidade do primeiro nível de cuidados à saúde e faz parte de uma estratégia para aprimorar o planejamento e gestão dos serviços de saúde por autoridades. O contexto de pandemia da COVID-19 levou a uma situação inédita em vários municípios do estado de São Paulo: a diminuição do horário de funcionamento e o fechamento das Unidades Básicas de Saúde (UBSs), gerando dificuldades de acesso da população à Atenção Primária. Vários estudos apontam diversos fatores que podem interferir nas ICSAP, dentre eles o horário de atendimento e as barreiras de acesso, que vão desde as geográficas à oferta de profissionais e serviços. Considerando-se que o acesso às UBSs ficou prejudicado durante a pandemia, é possível que haja um impacto nas ICSAP ocorridas no estado.  Nesse sentido, o objetivo é descrever a evolução das ICSAP no estado de São Paulo, entre os anos de 2008 e 2023. Trata-se de um estudo ecológico, quantitativo e descritivo, com dados de origem secundária, obtidos do Sistema de Informações Hospitalares do SUS (SIH/SUS), disponíveis na base de dados governamental DATASUS. Os resultados finais demonstram que houve uma queda das ICSAP ao longo dos anos, acentuada no período da pandemia, e posterior aumento das ICSAP nos anos de 2022 e 2023. Com os resultados, pretende-se contribuir para o conhecimento do perfil dessas internações, ainda não estudado, e subsidiar a organização de ações a fim de minimizá-las.
Endometriose e infertilidade: Atualizações acerca dos aspectos fisiopatológicos e do tratamento da associação
Authors: Nunes Luana Moreira Resende , Toledo Marcela Pereira , Nunes Luísa Moreira Resende , Altivo Yasmin Lage , Veloso Bruna Carvalho
Published: September 2024

Introdução: A endometriose é um distúrbio ginecológico benigno que afeta, principalmente, mulheres em idade fértil. Sendo uma doença multissistêmica, além do aparelho reprodutor feminino, porções intestinais e estruturas do sistema urinário também podem ser acometidas. Sua fisiopatologia é complexa e multifatorial, bem como o estabelecimento do diagnóstico. O tratamento é multidisciplinar e multimodal. Objetivo: O presente estudo teve como objetivo avaliar os aspectos clínicos, epidemiológicos e fisiopatológicos da associação entre a infertilidade e a endometriose. Materiais e Métodos: Trata-se de uma revisão integrativa de literatura acerca das características clínicas gerais sobre a associação entre a endometriose e a infertilidade. Utilizou-se a estratégia PICO para a elaboração da pergunta norteadora. Ademais, realizou-se o cruzamento dos descritores “Endometriose”; “Infertilidade”; “Tratamento”, nas bases de dados National Library of Medicine (PubMed MEDLINE), Scientific Eletronic Library Online (SCIELO), Ebscohost, Google Scholar e Biblioteca Virtual de Saúde (BVS). Resultados e Discussão: Os estudos mostram que a associação entre a endometriose e a infertilidade envolve nuances específicas dentro da medicina, perpassando por aspectos fisiopatológicos, clínicos, epidemiológicos e terapêuticos. Conclusão: A associação entre a infertilidade e a endometriose já é bem estabelecida na literatura, envolvendo a interação de múltiplos fatores fisiopatológicos. Para se aborda-la corretamente, hoje, existem técnicas medicamentosas, cirúrgicas e ainda as técnicas de reprodução assistida, devendo ao médico analisar e selecionar o tratamento mais adequado para cada paciente.
Diagnósticos diferenciais essenciais na avaliação clínica da Apendicite Aguda
Authors: Carvalhais Bárbara Salvador , Resende Maíra Guimarães Daher , Costa Luiza Albuquerque Miqueri da , Fernandes Brenda Padilha , Barros Bruna Espadinha Rossi de
Published: September 2024

Introdução: A apendicite aguda (AA) ocorre quando há uma obstrução do orifício do apêndice vermiforme, o que resulta em inflamação e distensão progressiva que pode comprometer a vascularização. Diversos mecanismos podem resultar em dor abdominal aguda ou abdome agudo, necessitando de uma compreensão da amplitude das possíveis causas. Objetivo: Identificar os principais diagnósticos diferenciais que mimetizam o quadro clínico da AA e seus possíveis padrões de diferenciação. Materiais e Métodos: Trata-se de uma revisão integrativa de literatura. Utilizou-se a estratégia PICO para a elaboração da pergunta norteadora. Ademais, realizou-se o cruzamento dos descritores “Apendicite Aguda”, “Diagnóstico Diferencial”, “Apresentação Clínica”, nas bases de dados National Library of Medicine (PubMed MEDLINE), Scientific Eletronic Library Online (SCIELO), Ebscohost, Google Scholar e Biblioteca Virtual de Saúde (BVS). Resultados e Discussão: É essencial que o quadro clínico da AA, bem como seus achados laboratoriais e de imagem sejam bem conhecidos, para identificação de possíveis variações que mimetizam a apresentação da dor abdominal característica, como por exemplo em casos de diverticulite cecal e de Meckel, da Doença de Crohn, condições ginecológicas e obstétricas, Linfadenite Mesentérica e cólica renal. Conclusão: o conhecimento detalhado dos diagnósticos diferenciais e o levantamento das hipóteses diagnósticas em casos oportunos é crucial para o manejo clínico adequado de pacientes com dor abdominal aguda, garantindo melhores desfechos e minimizando riscos associados a diagnósticos errôneos.
Os aspectos que afetam a qualidade de vida do cuidador informal
Authors: Legatti Júlia Nascimento , Rocha Giovana Vilela , Gonçalves Lucas Ferreira , Souza Thaynara Camilo Silva de , Vilela Frederico Vilani
Published: September 2024

A expectativa de vida da população brasileira está em ascensão, o que tem aumentado a necessidade de cuidadores, tanto formais quanto informais. Cuidadores formais são profissionais capacitados e remunerados para essa função, enquanto os informais são geralmente familiares que assumem essa responsabilidade em momentos de necessidade, como o cuidado de um membro familiar acamado. A preocupação principal com pacientes acamados geralmente se concentra na saúde deles, muitas vezes negligenciando os impactos físicos e psicológicos que sobrecarregam os cuidadores informais. Esta sobrecarga pode causar sofrimento ao cuidador, limitando sua vida pessoal e afetando relacionamentos afetivos e profissionais, além de reduzir sua rede de apoio social. Essa rotina estressante pode deteriorar a qualidade de vida do cuidador, que muitas vezes coloca o bem-estar do paciente acamado acima do próprio. O objetivo desse trabalho é identificar e avaliar a sobrecarga dos cuidadores de pacientes acamados na microárea da UBS Sebastião Amorim e propor estratégias para melhorar sua qualidade de vida.
PENDEKATAN KAJIAN ISLAM PRESPEKTIF SARJANA MUSLIM DAN RICHARD C. MARTIN
Authors: Luthfi Hidayah Nur'aini  , Muzammil Shofiyullah
Published: September 2024

Abstrak
Pendekatan Studi islam merupakan suatu ilmu atau pengetahuan bagaimana cara kita mendekati atau mengenal lebih dalam tentang islam baik dari segi tauhid dan fiqih,sehingga dapat membentuk karakter manusian menjadi lebih baik dan beradap.Pendekata Studi islam merupakan suatu cara kerja ataupun cara berfikir seseorang untuk mengetahui dan mendalami islam secara luas dan menyeluruh agar tidak muncul pola fikir yang dangkal.Pendekatan studi islam adalah sebuah pendekatan atau proses pembelajaran yang memudahkan kita dalam memahami serta mendalami hakikat dari agama islam,dengan melakukan pendekatan studi islam kita lebih mengenal lebih dalam lagi tentang islam dan bagaimana berjalannya agama tersebut. Kajian akademik terhadap Islam dalam diskursus Kontemporer mengadaptasi metodologi dan epistemologi yang telah lama berkembang di Barat. Adaptasi terhadap metodologi keilmuan Barat (diyakini) menjadi sebuah keniscayaan sebagai perspektif dalam memandang Islam, dengan menggunakan paradigma seseorang, pendekatan dan metode yang terakumulasi dinamis dalam perkembangan ilmu pengetahuan tentang Islam. Hanya saja, perkembangan studi Islam bagi para ilmuan studi kajian agama masih terpecah belah berdasarkan perspektif yang dibangun. Sehingga pengajaran Islamic Studies terkesan menjadi dangkal, rentan terhadap konflik, tidak mendalam dan tidak komprehensif.
PENGUATAN AQIDAH ASWAJA AN-NAHDHIYAH MELALUI TRADISI SEKATEN DI MASYARAKAT JAWA
Authors: Ma'arif A. Samsul , Azizah Ma’rufatul , Laillatul Fitri Izzah , Amalia Kharisma
Published: September 2024

This article describes the richness of Indonesian culture as reflected in the diversity of natural resources, people, tribes, languages ​​and traditions. The focus is on the importance of traditional ceremonies as an integral part of people's lives, even though they are threatened with extinction if they lose their relevance. This research highlights the role of hereditary rules in preserving traditional ceremonies as well as the cultural mix between Islam and local traditions, as seen in the Sekaten ceremony. By examining the origins and purpose of the Sekaten ceremony, this article illustrates how Indonesia's cultural diversity creates a unique cultural heritage, combining elements of local culture with Islamic teachings.
STRATEGI KOMUNIKASI POLITIK PARTAI PERSATUAN PEMBANGUNAN (PPP) DI KABUPATEN GORONTALO
Authors: Istyan Harun Nur , Napir Suaib , Nuna Muten , Hunawa Robby , A. Sahi Nirmala
Published: September 2024

Partai Persatuan Pembangunan (PPP)  in the 2019 Election in Gorontalo Regency showed extraordinary achievements, where PPP's vote acquisition increased by 250% from PPP's vote acquisition in the 2014 election. With this increase in votes, PPP's vote acquisition in the Gorontalo Regency DPRD experienced a significant increase from 4 the seats in the 2014 election results became 7 seats in the 2019 election results, which led PPP to become the chairman of the Gorontalo Regency DPRD Chairperson. Of course, this achievement is the success of the PPP strategy, both in beating its legislative candidates and in the communication that is built in the midst of society. This qualitative descriptive research by prioritizing primary data and secondary data focuses on seeing how PPP's political communication strategy won in Gorontalo District. The results of the study show that the United Development Party's winning strategy for Gorontalo Regency in the 2019 legislative election uses a winning strategy that utilizes marketing politics for campaign strategies both to gain political support in general elections and to maintain an image during the election break. The obstacles faced by PPP candidates in the implementation of the 2019 legislative elections in Gorontalo Regency include money politics, black campaigns, political apathy, and overlapping claims between fellow candidates on the same choice basis.
PENGARUH KUALITAS PELAYANAN PUBLIK TERHADAP KEPUASAN PELANGGAN DI PERUSAHAAN DAERAH AIR MINUM (PDAM) TIRTA PATRIOT KOTA BEKASI
Authors: Susanti Hartono Rina , Nuraini Siti , Sanubari Pria
Published: September 2024

This research titled The Effect of Public Service Quality Towards Costumer Satisfaction in PDAM Tirta Patriot Kota Bekasi. Based on the problem about costumer satisfaction about this matter with service quality that has not optimal yet. The purpose of this research was to know tangible, responsiveness, reliability, assurance and emphaty effects towards satisfaction of PDAM’s costumer in Kota Bekasi. This research used survey method with the population is all costumer of PDAM Tirta Patriot Kota Bekasi with total sample 395 costumers. Data collection technique that used in this research was random sampling. Analysis technique using correlation coefficient technique, with test T and test F using SPSS software. The result of this research shows that physical evidence (tangible) has positive and significance effects towards satisfaction of PDAM Tirta Patriot Kota Bekasi costumers. Responsiveness has positive and significance effects towards satisfaction of PDAM Tirta Patriot Kota Bekasi costumers. Reliability has positive and significance effects towards satisfaction of PDAM Tirta Patriot Kota Bekasi costumers. Assurance has positive and significance effects towards satisfaction of PDAM Tirta Patriot Kota Bekasi costumers. Emphaty has positive and significance effects towards satisfaction of PDAM Tirta Patriot Kota Bekasi costumers.
NAVIGATING GOVERNANCE FOR EQUITABLE HEALTH SYSTEMS: ETHICAL DIMENSIONS, IDEOLOGICAL IMPACTS, AND EVIDENCE-BASED IMPROVEMENTS
Authors: Komalasari Rita , Mustafa Cecep
Published: September 2024

The essay's purpose is to comprehensively address the gaps in the literature by analyzing the ethical dimensions of selective partnerships, the influence of political ideologies, the importance of comprehensive analytical work, and the synthesis of insights from diverse regions. These elements collectively contribute to evidence-based governance improvements that foster equitable resource allocation and enhanced health outcomes. Drawing from an extensive review of existing literature, the essay synthesizes insights from empirical case studies in both European and Asian contexts. The theoretical framework used—the "Political Economy of Health Governance"—provides a comprehensive lens to examine the intricate interplay between political, economic, and ethical factors that shape governance practices within health systems. The analysis reveals several novel perspectives that offer fresh insights into evidence-based governance improvements. The ethical dimensions of selective partnerships are explored, shedding light on potential equity implications. The impact of political ideologies on governance practices is uncovered, emphasizing the need for alignment with equitable health outcomes. The essay advocates for comprehensive analytical work as a precursor to policy, ensuring transparent decision-making and stakeholder inclusivity. By synthesizing insights from diverse regions, the essay enriches the understanding of governance qualities that drive successful health system reforms. In conclusion, this essay contributes to the field by addressing existing gaps in the literature and offering a holistic view of governance's impact on health systems performance. The synthesis of diverse perspectives and the application of the "Political Economy of Health Governance" theory provide a nuanced understanding of evidence-based governance improvements. These insights hold the potential to reshape policy paradigms, promoting equitable resource allocation and enhanced health outcomes within health systems.
DAMPAK SOSIAL EKONOMI MASYARAKAT TERHADAP KESEJAHTERAAN PETANI JAGUNG REBUS DI KELURAHAN KAISABU BARU KECAMATAN SORAWOLIO
Authors: Syarifudin Agustina , Wijaya Andy Arya Maulana , Sadat Anwar
Published: September 2024

Corn is a one of horticultural commodity in Kota Baubau, that is widely cultivated by producers in various farming businesses. To increase sweet corn production according to consumer demand, farmers use empty land to plant sweet corn in order to meet consumer demand. The people of Kaisabu Baru, apart from being farmers, are also direct sellers of boiled corn from their harvest in order to increase farmers' income to meet their social and economic needs. The size of the farmer's income greatly influences the farmer's own motivation in carrying out his farming business. The aims of this research are 1) to find out the social and economic impact of the boiled corn farming community in Kaisabu Baru Village, Sorawolio District. 2) To find out what the level of welfare of the boiled corn farming community is in Kaisabu Baru Village, Sorawolio District. The sampling method in this research is the purposive sampling method. Data processing and analysis uses one method, namely descriptive qualitative. The results of the research show that 1) the socio-economic impact felt by boiled corn farmers has provided positive changes. 2) the level of welfare of the boiled corn farming community in Kaisabu Baru Village has increased
PENGARUH KEBIJAKAN STANDAR PELAYANAN MINIMAL PENGADUAN KONSUMEN DAN SUMBER DAYA MANUSIA TERHADAP KUALITAS PELAYANAN PUBLIK
Authors: Purwaganda Salya , Kuswandi Aos
Published: September 2024

The objectives of this research are: 1. to determine the level of influence for minimum service standard policies on regional mineral water companies tirta patriot in the northern Bekasi district on the quality of public services. 2. to determine the level of influence of human resources in regional mineral water companies tirta patriot in the northern bekasi sub-district towards the quality of public services. 3. to find out the purpose of the influence of the minimum service standard policy and human resources on the regional water company tirta patriot in the northern bekasi sub-district, jointly on the quality of publicservices.Research carried out on regional mineral water companies tirta patriot water for the district in North Bekasi, the results of the study showed that the minimum standard of service was consumer complaints. (x1) influences the regression model y 0,578 so also with human resources (x2) significantly influences the quality of public services (y) with the regression model y 0,304 . 0,578 while based on the test results f, obtained f count for8,791 > f table 3,12 with a significant level . 3,12 because of the probability value < . 8,791that is (3,12 < 8,791) then hypothesis is accepted which means there is influence between the minimum service standard policy variable (x1) and the natural resource variable (x2) together simultaneous quality of public services (y).
PENGAWASAN FUNGSI PERIZINAN OLEH DINAS PENATAAN RUANG KOTA BANDUNG DALAM PEMBANGUNAN APARTMENT THE MAJ COLLECTION
Authors: Karniawati Nia , Nurfazriah Fanisa
Published: September 2024

The purpose of this study is to find out how far the licensing function is in the use of space in the city of Bandung in the construction of Apartment The Maj Collectin which is located in the Dago area. This study uses a qualitative descriptive method, using a literature study. The results of this study, the licensing function in the city of Bandung is not yet optimal, seen from the case of the construction of Apartment The Maj Collection. The conclusion of this study shows that the licensing function for spatial planning in the city of Bandung is still far from what was expected and the local government has not realized the awareness of all government officials. As a result, there has been a change in land use in the area which will have an impact on environmental damage and natural disasters such as landslides and floods.
Preparing Students for Civic Engagement through Project Citizen
Authors: Owen Diana , Irion-Groth Alissa
Published: September 2024

This study examines the effectiveness of the Center for Civic Education’s Project Citizen teacher professional development program and curriculum intervention in producing positive student learning outcomes that support civic engagement. A three-year national study was conducted by the Civic Education Research Lab at Georgetown University from 2020-2023, during the height of the COVID-19 pandemic. The research employed RCTs of secondary school students enrolled in Project Citizen and control group students who took a conventional civics class. The study confirmed the efficacy of project-based learning conveying civic skills and orientations conducive to civic engagement. Project Citizen students’ problem-solving and civic expression skills improved significantly. They reported a greater desire to vote if given the opportunity and felt better prepared to take part in the civic life of their community. The gains in civic skills and propensity for engagement were greater for Project Citizen students than those in the control group.
Conflict and nation: The colonial origins of ethnic exclusion and discrimination in Latin America
Authors: Galano Toro Paola , Schenoni Luis L. , Madrid Raul L.
Published: September 2024

Why do some ethnic groups gain rights through mobilization against the state, while others become targeted for doing so? We argue that whether mobilization leads to inclusion or further exclusion of peripheral ethnic groups depends on the long-term trajectory of conflict. When peripheral groups have a history of conflict with the state, they often develop an oppositional identity that core groups can frame as a threat, thereby justifying intensified targeting and exclusion. We test this argument in the context of nineteenth-century South America, where core Creole elites established new nations on a fluid sociopolitical landscape, shaping ethnic boundaries that were still malleable while facing multiple and frequent conflicts with these groups. Our findings suggest that patterns of colonial-era conflict between white and non-white groups determined whether later inter-ethnic conflicts during state and nation-building led to ethnic exclusion and targeting.
Determining calf traceability and cow–calf relationships in extensive farming using geolocation collars and BLE ear tags
Authors: Vidal-Cardos Roger , Fàbrega Emma , Dalmau Antoni
Published: September 2024

Extensive farming is often considered very beneficial to animals for its potential to enhance animal welfare, providing animals with free-range access to their natural environment where they can engage in innate behaviors like grazing and exploration. However, despite these benefits, extensive production still faces welfare and health challenges due to unpredictable weather conditions and limited supervision by stockholders. Moreover, increasing consumer demand for information regarding food quality, safety, and production conditions poses a challenge for extensive farming, where animals are less controlled. Precision livestock farming (PLF) emerges as a possible solution by enabling the continuous real-time monitoring of the health, welfare, and behavior of animals. A novel approach combining geolocation collars for cows and Bluetooth low energy (BLE) ear tags for calves appears promising to enhance traceability and monitoring in extensive farming. Nevertheless, challenges persist, including limitations in the data transmission capacity and associated costs. This study evaluated the effectiveness of combining geolocation collars and BLE ear tags for monitoring calf traceability and cow–calf relationships across three scenarios: 1) Equilibrated: same collar/ear tag ratio; good coverage; 2) intermediate: more collars than ear tags; fair coverage; 3) worst: more ear tags than collars; lousy coverage. Our results indicate that the equilibrated scenario (ES) with an equal number of geolocation collars and BLE ear tags, was the best scenario, demonstrating the highest fix rate (22%) and the longest mean consecutive days of detecting the same ear tag (22.30 days), followed by the intermediate scenario (IS) and the worst scenario. In all scenarios, there was a mean period of 14–15 d without detecting a calf. However, this shortcoming can be overcome as calves usually graze alongside their mothers, ensuring comprehensive traceability in farm breeding. Additionally, by comparing differences in the number of ear tags received from offspring compared to other calves, the BLE ear tags successfully associated every mother with their calf in the ES and IS. Finally, this valuable information, would enable the development of a traceability system that ensures transparency and reliability throughout the supply chain and could allow consumers to access to product information related to animal welfare.
Status of off-bottom mariculture in wave-exposed environments. Part 2. Comparative loading and motion of longline designs currently used in exposed commercial farms
Authors: Gagnon Marc
Published: September 2024

A global inventory of extractive species mariculture in wave-exposed temperate waters shows that the longline is the technology used in more than 99% of the sites (Part 1 of this review). In this second part, I compare the static (longline at rest), quasi-static (tidal sea surface elevation, steady currents and mainline lifting operation) and dynamic (wind seas and swells) loading and motion of surface, semi-submerged and fully submerged longlines used to grow bivalves and kelp. This review is based on a hundred papers published on the subject mostly after 2010 and on simple analytical models used to illustrate the many compromises that must be made to ensure the survivability of the structure and the survival (retention), growth and quality of the cultured biomass. Surface longlines are unsuitable for fully exposed environments. To mitigate storm energy it is necessary to minimize the volume of surface buoys and submerge the mainline to the maximum depth possible. There is however a limit to minimizing the volume of surface buoys due to the uplifting of the mainline by currents. In the case of kelp, its optimal growing depth is within a few meters from the sea surface. This limitation can be partly circumvented by having the kelp float above the mainline. In the case of bivalves, mainline depth can be tens of meters below the sea surface. This comes with some disadvantages including difficulties in maintaining the delicate buoyancy balance, particularly for fully submerged longlines without legs, and reduced access to the mainline, particularly for fully submerged longlines with legs. Devices that allow autonomous or remote-controlled changes of mainline depth on a daily, occasional (husbandry and harvest operations) or seasonal basis have been tested but are not yet used commercially on longlines.
Regulation of TGF-β1-induced fibroblast differentiation of human periodontal ligament stem cells through the mutually antagonistic action of ectonucleotide pyrophosphatase/phosphodiesterase 1 and 2
Authors: Ju Onyou , Ko Seon-Yle , Jang Young-Joo
Published: September 2024

Human periodontal ligament stem cells (hPDLSCs) differentiate into periodontal ligament (PDL) fibroblasts, osteoblasts, and cementoblasts. To identify inducers of PDL fibroblastic differentiation, monoclonal antibody series were developed a series of against membrane/extracellular matrix (ECM) molecules through decoy immunization. The anti-PDL13 antibody targets ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), renowned for regulating skeletal and soft tissue mineralization. ENPP1 accumulates in the periodontal ligament region of tooth roots, and specifically localizes to the cell boundaries and elongated processes of the fibroblastic cells. As ENPP1 expression increases during fibroblastic differentiation, mineralization induced by tissue-nonspecific alkaline phosphatase (TNAP), a pyrophosphate-degrading enzyme, is completely inhibited. This is consistent with ENPP1 and TNAP acting in opposition, and TGF-β1-induced ENPP1 expression creates an essential environment for PDL fibroblast differentiation. Representative fibroblastic differentiation markers decrease with endogenous ENPP1 inhibition by siRNA and antibody blocking. ENPP2 generates lipid signaling molecules. In contrast to ENPP1, ENPP2 disappears in TGF-β1-induced PDL fibroblasts. Ectopic expression of ENPP2 hinders TGF-β1-induced PDL fibroblastic differentiation. Suppression of ENPP1 and ENPP2 leads to severe defects in undifferentiated and differentiated cells, demonstrating that these two factors play opposing roles in soft and hard tissue differentiation but can complement each other for cell survival. In conclusion, increased ENPP1 is crucial for TGF-β1-induced PDL differentiation, while ENPP2 and TNAP can inhibit ENPP1. ENPP1 and ENPP2 exhibit complementary functions in the cell survival.
Case Report: Acute myocarditis in a patient with Duchenne muscular dystrophy
Authors: Zhang Xinyuan , Guo Yingkun , Xu Huayan
Published: September 2024

Background

Cardiovascular complications are the leading cause of death among individuals with Duchenne muscular dystrophy (DMD). However, due to the difficulty in evaluating individuals with inactive DMD, acute myocardial injury may be overlooked.

Case presentation

An 11-year-old boy with DMD presented to the emergency department with a 5-day history of persistent nasal congestion, runny nose, and cough. He was regularly taking prednisolone acetate, angiotensin-converting enzyme (ACE) inhibitors, and β-blockers for suspected DMD-associated cardiomyopathy. Upon presentation, a substantially elevated cardiac troponin I (cTnI) level of 19.8 μg/L and abnormal electrocardiogram (ECG) results were detected. Further cardiac magnetic resonance imaging (CMR) showed myocardial inflammation with localized T2 hyperintensity from the basal to middle lateral and inferior walls, as well as late gadolinium enhancement (LGE) from the basal to apical inferior lateral walls, supporting a diagnosis of acute myocarditis. Subsequently, the patient showed clinical improvement in response to combination treatment with intravenous immunoglobulin, oral prednisolone acetate, potassium chloride sustained-release tablets, anti-heart failure medication, and broad-spectrum antibiotics.

Conclusions

We report a rare case of acute myocarditis in a patient with DMD, potentially due to upper respiratory tract infection. This case highlights the importance of early myocarditis recognition and treatment in patients with DMD.
Effectiveness of β-blockers in improving 28-day mortality in septic shock: insights from subgroup analysis and retrospective observational study
Authors: Zhang Ling , Yu Yue , Wu Tong , Pan Tingting , Qu Hongping , Wu Jingyi , Tan Ruoming
Published: September 2024

Background

In recent years, septic shock remains a common fatal disease in the intensive care unit (ICU). After sufficient fluid resuscitation, some patients still experience tachycardia, which may lead to adverse effects on cardiac function. However, the use of β-blockers in the treatment of septic shock remains controversial. Thus, the purpose of this study is to evaluate the efficacy of β-blockers in the treatment of patients with septic shock and explore the most appropriate patient subgroups for this treatment.

Methods

This retrospective observational study enrolled septic shock patients from the Medical Information Mart for Intensive Care (MIMIC)-IV and used propensity score matching (PSM) to balance some baseline differences between patients with and without β-blockers treatment. The primary outcome was the 28-day mortality. Length of stay (LOS) in the ICU and hospital, and the degree of support for organs such as circulatory, respiratory and renal systems were also assessed. Subgroup analysis and multivariate logistic regression were performed to determine the relationship between β-blockers therapy and 28-day mortality in different patient groups.

Results

A total of 4,860 septic shock patients were enrolled in this study and 619 pairs were finally matched after PSM. Our analysis revealed that β-blocker therapy was associated with a significant improvement in 28-day mortality (21.5% vs. 27.1%; P = 0.020) and led to a prolonged LOS in both the ICU and hospital. Subgroup analysis indicated that there was an interaction between cardiovascular diseases and β-blocker therapy in patients with septic shock. Patients with pre-existing heart disease or atrial arrhythmias were more likely to derive benefits from β-blocker treatment.

Conclusion

We found β-blockers therapy was effective to improve 28-day mortality in patients with septic shock. Patients in the subgroup with cardiovascular diseases were more likely to benefit from β-blockers in mortality.
AI-accelerated therapeutic antibody development: practical insights
Authors: Santuari Luca , Bachmann Salvy Marianne , Xenarios Ioannis , Arpat Bulak
Published: September 2024

Antibodies represent the largest class of biotherapeutics thanks to their high target specificity, binding affinity and versatility. Recent breakthroughs in Artificial Intelligence (AI) have enabled information-rich in silico representations of antibodies, accurate prediction of antibody structure from sequence, and the generation of novel antibodies tailored to specific characteristics to optimize for developability properties. Here we summarize state-of-the-art methods for antibody analysis. This valuable resource will serve as a reference for the application of AI methods to the analysis of antibody sequencing datasets.
A machine learning approach towards assessing consistency and reproducibility: an application to graft survival across three kidney transplantation eras
Authors: Achilonu Okechinyere , Obaido George , Ogbuokiri Blessing , Aruleba Kehinde , Musenge Eustasius , Fabian June
Published: September 2024

Background

In South Africa, between 1966 and 2014, there were three kidney transplant eras defined by evolving access to certain immunosuppressive therapies defined as Pre-CYA (before availability of cyclosporine), CYA (when cyclosporine became available), and New-Gen (availability of tacrolimus and mycophenolic acid). As such, factors influencing kidney graft failure may vary across these eras. Therefore, evaluating the consistency and reproducibility of models developed to study these variations using machine learning (ML) algorithms could enhance our understanding of post-transplant graft survival dynamics across these three eras.

Methods

This study explored the effectiveness of nine ML algorithms in predicting 10-year graft survival across the three eras. We developed and internally validated these algorithms using data spanning the specified eras. The predictive performance of these algorithms was assessed using the area under the curve (AUC) of the receiver operating characteristics curve (ROC), supported by other evaluation metrics. We employed local interpretable model-agnostic explanations to provide detailed interpretations of individual model predictions and used permutation importance to assess global feature importance across each era.

Results

Overall, the proportion of graft failure decreased from 41.5% in the Pre-CYA era to 15.1% in the New-Gen era. Our best-performing model across the three eras demonstrated high predictive accuracy. Notably, the ensemble models, particularly the Extra Trees model, emerged as standout performers, consistently achieving high AUC scores of 0.95, 0.95, and 0.97 across the eras. This indicates that the models achieved high consistency and reproducibility in predicting graft survival outcomes. Among the features evaluated, recipient age and donor age were the only features consistently influencing graft failure throughout these eras, while features such as glomerular filtration rate and recipient ethnicity showed high importance in specific eras, resulting in relatively poor historical transportability of the best model.

Conclusions

Our study emphasises the significance of analysing post-kidney transplant outcomes and identifying era-specific factors mitigating graft failure. The proposed framework can serve as a foundation for future research and assist physicians in identifying patients at risk of graft failure.