bluuebunny/crossref_metadata_2025 huggingface dataset:
Sistem Publikasi Pendaftaran Tanah (Kajian Sistem Publikasi Negatif Bertendensi Positif)
Authors: Suhariono Agus , Romadhona Mochamad Kevin , Yanuardi Muhammad Indra , Nampira Muammar Zaid
Published: March 2022

AbstractThe purpose of this writing is to determine the effectiveness of the power of proof of title to land that has met the elements stipulated in Article 32 paragraph (2) of Government Regulation Number 24 of 1997 concerning Land Registration before the court. This writing method is a normative juridical type using the statutory approach, conceptual approach and case approach. From the results of the discussion, it is known that although the elements of the provisions stipulated in Article 32 paragraph (2) have been fulfilled late, it does not make the land title certificate have absolute, irrevocable power of proof. It is evident from a number of court decisions that they still cancel land title certificates even though they have fulfilled these elements.Keywords: Certificate; Publication System; Multiple Proof.AbstrakTujuan penulisan ini adalah untuk mengetahui efektifitas kekuatan pembuktian serfifkat hak atas tanah yang telah memenuhi unsur-unsur yang diatur dalam Pasal 32 ayat (2) Peraturan Pemerintah Nomor 24 Tahun 1997 tentang Pendaftaran Tanah dimuka pengadilan. Metode penulisan ini adalah penulisan bertipe yuridis normatif dengan menggunakan pendekatan peraturan perundang-undangan, pendekatan konseptual dan pendekatan kasus. Dari hasil pembahasan diketahui bahwa walaupun unsur-unsur ketentuan yang diatur dalam Pasal 32 ayat (2) tersebut telat terpenuhi tidak menjadikan sertifikat hak atas tanah memiliki kekuatan pembuktian mutlak yang tidak dapat dibatalkan. Terbukti dari beberapa putusan pengadilan tetap membatalkan sertifikat hak atas tanah walaupun telah memenuhi unsur-unsur tersebut.Kata Kunci: Sertifikat; Sistem Publikasi; Alat Pembuktian Multak.
The Effect of Drying Method on Potential Antioxidants in Ethanol Extract of Sungkai Leaf (Parenoma Canescens Jack.) Simplicia from Kalimantan
Authors: Wati Fahrina Kasuma , Hasnah Siti Hasnah -
Published: March 2022

Sungkai (P. canescens) is a medicinal plant whose leaves are used to alleviate fever and strengthen the body's immune system. This study aimed to determine the effect of the simplicia drying technique on the antioxidant potential of the ethanol extract of Sungkai leaves from Kalimantan. The drying method employed was oven drying at 70°C, oven drying at 50°C, sun drying, and wind drying. The study's findings indicated that the antioxidant activity of all drying techniques was in the very active category. The drying method with the lowest antioxidant potential was oven drying at 50°C with IC50 value of 13.340 ppm, wind drying with IC50 value of 14.610 ppm, sun drying with IC50 value of 16.799ppm, and oven drying at 70°C with IC50 value of 17.034 ppm. Keywords: Sungkai leaf ; IC50; antioxidant
PENGARUH KONSENTRASI MIKROBA SACCHAROMYSES CEREVISIAE DALAM PEMBUATAN BIOETANOL MENGGUNAKAN BAHAN CACAHAN TONGKOL JAGUNG MANIS
Authors: Al Aziz Maulana Akbar
Published: March 2022

Kebutuhan energi bahan bakar yang berasal dari eksplorasi fosil terus meningkat seiring dengan meningkatnya pertumbuhan industri dan ekonomi. Hal tersebut dapat menjadi masalah ketika negara belum bisa mengurangi ketergantungan terhadap bahan bakar fosil atau bahan bakar minyak (BBM), sedangkan cadangan sumber energi tersebut makin terbatas. Kebijakan mengurangi konsumsi energi bukan merupakan langkah tepat. Bioetanol merupakan jenis energi yang berpotensi ditawarkan untuk mengurangi ketergantungan pada energi fosil. Bioetanol dapat diproduksi dari bahan baku tanaman yang mengandung pati atau karbohidrat. Penelitian ini dilaksanakan di Laboratorium Teknik Sistem Termal dan Energi Terbarukan dan Laboratorium Pangan dan Gizi, Universitas Jenderal Soedirman. Penelitian ini dilaksanakan pada bulan Januari 2020 sampai dengan September 2020. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) dengan dua faktor yaitu konsentrasi mikroba Saccharomyces Cereviceae 0%, 5%, 7,5% dan 10% dan lama fermentasi 2 hari, 4 hari, dan 6 hari. Masing-masing perlakuan diulang sebanyak 3 kali sehingga terdapat 36 unit percobaan. Variabel yang diamati yaitu kadar gula reduksi, kadar bioetanol, dan rendemen bioetanol. Penelitian ini bertujuan untuk mengetahui kadar bioetanol yang dihasilkan dari cacahan tongkol jagung manis dan mengetahui pengaruh konsentrasi mikroba Saccharomyses Cereviceae dan waktu fermentasi dalam memproduksi bioetanol dari tongkol jagung manis yang dicacah. Hasil penelitian menunjukan bahwa tongkol jagung manis memiliki kadar air 84% basis basah dan kadar gula 2,21%. Perlakuan konsentrasi mikroba 0% dengan waktu fermentasi 6 hari menghasilkan kadar gula reduksi paling tinggi yaitu 1,142 % (m/v). Konsentrasi mikroba Saccharomyses Cereviceae tidak berpengaruh nyata terhadap produksi kadar gula reduksi, sedangkan waktu fermentasi berpengaruh nyata terhadap produksi kadar gula reduksi. Rata-rata kadar bioetanol tertinggi sebesar 0,557% (v/v) hasil kombinasi perlakuan konsentrasi mikroba 7,5% dengan waktu fermentasi 4 hari (S3T2).
Mikro Turbin Angin Aerodinamika Kendaraan sebagai Sumber Energi Listrik Akumulator Kendaraan Bermotor
Authors: Roshan Fabian , Andrian Andrian , Ramadhanu Irkhas Ismaya
Published: March 2022

Banyaknya energi yang terbuang pada kendaraan yang mencapai 87,40% menyebabkan energi yang dapat dipakai hanya sedikit yaitu 12,60% sedangkan un- tuk beban energi yang diperlukan pada kendaraan cukup besar yaitu 77,92 watt. Pemanfaatan energi angin aerodinamika pada kendaraan menjadi salah satu cara untuk menghemat penggunaan bahan bakar dan akumulator sehingga diharapkan dapat memenuhi kebutuhan energi pada setiap komponen kendaraan. Berdasarkan pada persamaan yang sudah ada pada penelitian sebelumnya dihasilkan bahwa daya 4 mikro turbin dapat mencapai 10,84 watt dengan arus listrik 1,81 ampere. Persamaan yang digunakan adalah persamaan daya dan persamaan arus. Potensi mikro turbin yang dapat dimanfaatkan adalah pemanfataan waste energy (energi yang terbuang), penunjang energi listrik kendaraan, kendaraan lancar melaju, ben- tuk desain yang sederhana, menambah estetika kendaraan, dan harag produk ekonomis.
RIVIEW : APLIKASI PENGUNAAN SENSOR BERBASIS ION DALAM MENINGKATKAN AKURASI PEMBERIAN NUTRISI PADA SISTEM TANAM HIDROPONIK
Authors: Firdaus Jonni , Furqon Furqon
Published: March 2022

Pemenuhan kebutuhan pangan di dalam perkotaan dapat dilakukan melalui pemanfaatan lahan dan air yang lebih efisien dengan sistem tanam hidroponik. Penggunaan aliran nutrisi tertutup merupakan suatu cara untuk mengurangi biaya dan meminimalkan dampak lingkungan dari sistem hidroponik. Dalam sistem tertutup, sangat penting untuk menentukan konsentrasi nutrisi dalam larutan sisa untuk mengisi kembali larutan nutrisi dengan komposisi hara optimal. Saat ini pengukuran ketersediaan hara di dalam larutan nutrisi berdasarkan konduktifitas listrik (EC) yang memiliki kelemahan karena EC meter hanya dapat menggambarkan konduktifitas listrik dari total ion dan tidak mengukur konsentrasi masing-masing ion secara individu sehingga tidak dapat memantau kebutuhan tanaman secara real-time terhadap masing-masing ion di dalam larutan nutrisi. Untuk mengatasi permasalahan tersebut maka saat ini telah mulai dikembangkan teknologi ion selective electrodes (ISE) yaitu suatu sensor berupa elektroda yang dapat mengukur konsentrasi masing-masing ion di dalam larutan nutrisi hidroponik. Penerapan sensor ISE memberikan nilai akurasi yang tinggi terhadap pengukuran konsentrasi ion di dalam larutan nutrisi, sehingga bila dipadukan dengan mekanisme sistem kontrol yang dapat mengontrol penambahan jumlah ion kedalam larutan nutrisi pada sistem hodroponik secara tertutup sesuai kebutuhan tanaman, maka kesetimbangan jumlah ion pada larutan nutrisi akan tetap terjaga pada level kebutuhan tanaman sehingga tanaman dapat tumbuh dengan baik dan menghasilkan produktivitas optimum. Efisiensi penggunaan unsur hara juga meningkat dan dapat mengurangi pencemaran lingkungan karena sisa drainase nutrisi dapat digunakan kembali.
Anarquismo internacional: Educación, Cultura y Luchas Sociales
Authors: Solà Gussinyer Pere , Silva Doris Accioly e , Santos Luciana Eliza dos
Published: March 2022

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Omega-3 Polyunsaturated Fatty Acids: the Role in Prevention of Atrial Fibrillation in Patients with Coronary Artery Disease after Coronary Artery Bypass Graft Surgery
Authors: Rubanenko O. A. , Shchukin Yu. V. , Limareva L. V. , Ryazanova T. K. , Rubanenko A. O. , Davydkin I. L.
Published: March 2022

Aim. To estimate the role of omega-3 polyunsaturated fatty acids (PUFAs) administration in atrial fibrillation (AF) prevention after planned coronary artery bypass graft (CABG) surgery.

Material and Methods. Studied were 306 patients divided into two groups: patients of group I didn’t receive PUFAs (158 patients, 82.7% males) and patients of group II received PUFAs (148 patients, 89.3% males). PUFAs were prescribed in daily dose 2000 mg 5 days before surgery and in daily dose 1000 mg in postoperative period during 21 days.

Results. Postoperative AF (POAF) occurred in 29.7% patients in group I and in 16.9% patients in group II (р=0.009). We found that after CABG in patients of the I group median IL-6 level was 39.3% higher (p=0.001), interleukin-10 – 20.2% higher (p=0.01), superoxide dismutase – 78.9% higher (р<0.001), malondialdehyde – 33.8% higher (p=0.03), docosahexaenoic acid – 31.8% lower (p=0.01) and omega-3 index – 43.4%    lower (p=0.04) than in patients of the II group.

According to multivariate regression analysis we found significant association between the factors of inflammation, oxidative stress and the risk POAF development.

Conclusions. In patients who took PUFAs, we found less activation of inflammation, oxidative stress, the increasing of docosahexaenoic acid and omega-3 index accompanied by the decreasing of POAF development rates up to 12.8%.
Noncompact Myocardium with Dilated Phenotype: Manifestations, Treatment and Outcomes in Comparison with Other Forms of Dilated Cardiomyopathy Syndrome
Authors: Blagova O. V. , Pavlenko E. V. , Varionchik N. V. , Sedov V. P. , Gagarina N. V. , Mershina E. A. , Polyak M. E. , Zaklyazminskaya E. V. , Nedostup A. V.
Published: March 2022

Aim. To study the place of NCM in the structure of DCM, its clinical features and influence on prognosis in comparison with other forms of DCM syndrome.

Methods. The NCM registry includes 125 patients, mean age 46.4±15.1 years, 74 men and 51 women, median follow-up 14 [4.0; 41.0] months. The DCM registry included 365 patients, mean age 46.4±15.1 years, 253 men and 112 women, median follow-up 14 [5; 43.75] months. The examination included electrocardiography (ECG), ECG Holter monitoring, echocardiography, blood anti-heart antibody level evaluation, and additionally cardiac computed tomography, magnetic resonance imaging, DNA diagnostics (in the MYH7, MYBPC3, TPM1, TNNI3, TNNT2, ACTC1, TAZ, ZASP (LDB3), MYL2, MYL3, DES, LMNA, EMD, TTR gene panel), coronary angiography, right ventricular endomyocardial biopsy.

Results. The proportion of patients with DCM phenotype in the NCM registry was 40% (n=49), another 11% (n=15) had NCM diagnosed simultaneously with acute/subacute myocarditis. Lethality in these subgroups was 12.2% and 33.3%, respectively, and was significantly higher than in asymptomatic, ischemic and arrhythmic variants of NCM. In the DCM registry, the proportion of patients with NСM was 21% (n=78), and increased left ventricular (LV) trabecularity was detected in another 18% (n=64). DCM patients with and without NСM did not differ by baseline echocardiographic parameters, heart failure class, and cardiotropic therapy. Pathogenic mutations were detected in 14% of DCM patients with NCM and only 3% of other patients with DCM (p<0.001). Only in patients without NCM the presence of mutations had a significant effect on lethality. The patients with NCM compared with the others DCM patients showed significantly lower increase in EF in early and late period (from 31.0±10.2 to 34.8±11.0 and 37.1±10.9% [р<0.05] vs from 31.8±9.7 to 38.8±11.3 and 42.3±12.4% [р<0.01] respectively), a greater incidence of premature ventricular   beats (1568 [105;7000] vs 543.5 [77.75; 3194], p<0.05), appropriate defibrillator shocks and sudden deaths (17.9 vs 5.9%, p<0.001), intracardiac thrombosis (21.8 vs 13.5%, p=0.069) despite a greater frequency of anticoagulants (73.1 vs 57.4%, p<0<05). There were no significant differences in death (19.2 vs 18.5%) and transplantation (7.7 vs 3.8%) between patients with and without NCM. There were no cases of NCM regression.

Conclusion. NCM is an independent form of DCM syndrome, which is characterized by higher frequency of pathogenic mutations, arrhythmic events, worse response to cardiotropic therapy, higher frequency of intracardiac thrombosis. The absence of mortality differences can be explained by the higher frequency of preventive interventions in this category of patients with DCM (prescription of anticoagulants, defibrillator implantation, heart transplantation).
Assessment of Pre-test and Clinical Probability in the Diagnosis of Chronic Coronary Syndrome — What's New?
Authors: Sumin A. N. , Shcheglova A. V.
Published: March 2022

In the 2019 European Society of Cardiology (ESC) guidelines, the diagnostic algorithm for chronic coronary syndrome (CCS) was significantly changed, a significant revision of the pretest probability assessment scale (PTP) was made, an assessment of the clinical probability of obstructive coronary artery disease was proposed, the recommendations on the use of diagnostic tests in various groups of patients were updated. Such a radical change in approaches to the diagnosis of CCS raised many questions that had to be answered by further studies conducted in the past two years. The review provides data on the validation of the new PTP scale and the proposed assessment of the clinical probability of obstructive coronary artery disease, taking into account risk factors and with the additional inclusion of information on the calcium index of coronary arteries. The proposals of experts on new algorithms for the choice of non-invasive / invasive examination of this category of patients were also considered. Overall, the new PTV rating scale (ECS 2019) has been validated and validated in retrospective analyzes of cohort studies. The scale for assessing the clinical likelihood of obstructive coronary artery disease makes it possible to classify 3.8-5 times more patients as a low probability of coronary artery disease compared to the assessment of PTP alone. Assessment of the post-test probability of coronary artery disease does not allow to confirm the presence of obstructive lesion and was not used. The experts proposed new modifications of the diagnostic algorithm (with a detailed assessment of the clinical probability, as well as without taking it into account), which require verification in further studies. Therefore, it is advisable to conduct prospective studies to confirm the possibility of reducing the total number of non-invasive and invasive studies in patients with suspected coronary heart disease, as well as the safety of such a decrease in diagnostic procedures.
Polymorbidity and Polypragmasia in High and Very High Cardiovascular Risk Patients
Authors: Izmozherova N. V. , Popov A. A. , Kuryndina A. A. , Gavrilova E. I. , Shambatov M. A. , Bakhtin V. M.
Published: March 2022

Aim. Assessment of the level and structure of polymorbidity, features of pharmacotherapy therapy in patients of different age groups, belonging to the category of high and extremely high cardiovascular risk, observed in outpatient clinics.

Material and methods. The single-stage study included 282 patients of high and very high cardiovascular risk who were divided into three groups: (1) age 45-59 years, (2) 60-74 years, (3) ≥75 years. The structure of polymorbidity and features of pharmacotherapy in different age groups patients were evaluated. The frequency of polypragmasia was determined, and treatment adequacy in patients over 65 years of age was analyzed using the STOPP / START criteria and the Beers criteria of 2019.

Results. High and very high cardiovascular risk patients have been found to be highly polymorbid, polimorbidity level increasing with age. Thus, among elderly patients, ischemic heart disease, chronic heart failure (CHF) were more often detected, as well as a high frequency of concomitant and background conditions, especially bone and joint system involvement (osteoarthritis, rheumatoid arthritis). Polypragmasia (administration of ≥5 drugs) was detected in 150 patients (53.2%) and was more common among elderly patients. According to Beers criteria, there were 48 cases of inadequate medication prescribing in 46 (28.0%) elderly patients. According to 80 STOPP criteria, 75 cases of prescribing potentially non-recommended drugs to 55 patients (32.1%) were detected. According to 34 START criteria, 116 cases of non-prescribing of necessary drugs to 52 (30.4%) elderly patients were found. When assessing the frequency of prognosis modifying medication prescribing, patients with CHF in 107 (63.0%) cases received angiotensin converting enzyme inhibitors, and in 42 cases (24.5%) angiotensin II receptor antagonists had been prescribed.  Thus,  87.5%  CHF patients were receiving renin-angiotensin-aldosterone system blockers. Statins were administered in 225 (79.8%) cases, antiplatelet agents were pre-scribed in 157 (67.9%) cases, and 23 persons (9.9%) were on oral anticoagulants for atrial fibrillation.

Conclusion. In the structure of the studied cohort most of the high and very high cardiovascular risk outpatients were polimorbid, elderly and senile. Polypragmasia has been detected in more than half of elderly outpatients (53%), irrational medication was found in 28% to 30% elderly patients. Most patients with CHF were on statins, antithrombotic therapy, and renin-angiotensin-aldosterone system blockers.
Cardiovascular Effects of Metformin
Authors: Kurmanbekova B. T. , Noruizbaeva A. M.
Published: March 2022

Type 2 diabetes mellitus is one of the most important independent risk factors for the development, progression and mortality from cardiovascular diseases (CVD). The world communities are faced with the question of developing the optimal management tactics for such comorbidity patients. Thus, the prescribed drug should not only have an adequate hypoglycemic effect, but also have a number of cardioprotective properties, be safe in patients with CVD, and possibly even improve the prognosis and reduce mortality rates. This review is devoted to a representative of the biguanide class - metformin, which is one of the earliest and most effective antihyperglycemic drugs, both as monotherapy and in combination with other antihyperglycemic drugs and insulin; while the evidence base for its cardiovascular profile is only gaining momentum. Thus, the purpose of this review is to highlight the cardiovascular effects of metformin in the context of recent research.
Desain Pembelajaran Daring Statistika Berbasis Higher Order Thinking Skills Untuk Siswa SMP
Authors: Rosselyne
Published: March 2022

This article presents the development of instructional design in conditions of online learning following the Dick, Carey & Carey model on the topic of statistics for 7th grade of junior high school students in the 2nd semester. The material that will be discussed is presenting data. The instructional design was developed based on Higher Order Thinking Skills (HOTS), using Project-based Learning aided Microsoft Excel and Edmodo as a Learning Management System (LMS). The development begins with identifying and analyzing learning and students’ characteristics. Performance objectives, instrument assessment, development of learning strategies, formative and summative evaluation plans are also discussed in detail and in harmony with each other. At the end, we discuss things that must be considered in the implementation process.
Metformin in the management of patients with diabetes and advanced heart failure (HFrEF): a propensity score-matched analysis
Authors: Benes Jan , Kotrc Martin , Kroupova Katerina , Wohlfahrt Peter , Kovar Jan , Franekova Janka , Hegarova Marketa , Hoskova Lenka , Hoskova Eva , Pelikanova Terezie , Jarolim Petr , Kautzner Josef , Melenovsky Vojtech
Published: March 2022

Background: The role of metformin (MET) in the treatment of patients with advanced HFrEF and type 2 diabetes mellitus (DM) is not firmly established. We studied the impact of MET on metabolic profile, quality of life (QoL) and survival in these patients. Methods: A total of 847 stable patients with advanced HFrEF (57.4± 11.3 years, 67.7% NYHA III/IV, LVEF 23.6± 5.8%) underwent clinical and laboratory evaluation and were prospectively followed for a median of 1126 (IQRs 410; 1781) days for occurrence of death, urgent heart transplantation or mechanical circulatory support implantation. Results: A subgroup of 380 patients (44.9%) had DM, 87 of DM patients (22.9%) were treated with MET. Despite worse insulin sensitivity and more severe DM (higher BMI, HbA1c, worse insulin resistance), MET-treated patients exhibited more stable HF marked by lower BNP level (400 vs. 642 ng/L), better LV and RV function, lower mitral and tricuspid regurgitation severity, were using smaller doses of diuretics (all p< 0.05). Further, they had higher eGFR (69.23 vs. 63.34 ml/min/1.73m2) and better QoL (MLHFQ: 36 vs. 48 points, p= 0.002). Compared to diabetics treated with other glucose-lowering agents, MET-treated patients had better event-free survival even after adjustment for BNP, BMI and eGFR (p= 0.035). Propensity score-matched analysis with 17 covariates yielded 81 pairs of patients and showed a significantly better survival for MET-treated subgroup (p= 0.01).Conclusion: MET treatment in patients with advanced HFrEF and DM is associated with better quality of life and improved outcome, by mechanisms beyond the improvement of blood glucose control.
Training-induced change of tendon and muscle stiffness of the lower limb in professional female athletes: Assessment with shear wave elastography
Authors: Römer Claudia , Legerlotz Kirsten , Czupajllo Julia , Fischer Thomas , Wolfarth Bernd , Lerchbaumer Markus Herbert
Published: March 2022

Background: Shear Wave Elastography (SWE) is currently used to detect tissue pathologies. For preventive medicine, it may also be applied to uncover structural changes early on before they lead to functional impairment. Hence, it is important to examine the sensitivity of SWE and to investigate how stiffness measures are affected by methodological variables.Objective: To evaluate the acute effects of exercise activity on tendon and muscle stiffness measured by SWE.Methods: Standardized SWE examination of both lower limb tendon and muscles (achilles tendon (AT), Musculus soleus insertion (MS) and Musculus gastrocnemius (MG)) in longitudinal plane were performed in 24 healthy professional female athletes. Measurements were taken before and after a standardized treadmill exercise test. Baseline characteristics and parameters of performance were acquired. Results: In the overall cohort, baseline SWE assessment demonstrated a moderate to strong correlation between pre-exercise and post-exercise stiffness for MS (r=0.613), MG (r=0.609) and AT (r=0.583). In both muscles (Musculus soleus insertion and Musculus gastrocnemius) and achilles tendon, the linear regression shows an increase in stiffness for lower pre-exercise values and decreasing stiffness for higher pre-exercise values. This covariance between pre-exercise values and changes in stiffness is highly significant (p<0.001).Conclusion: SWE measurement revealed that in professional athletes acute exercise induces individually different tissue stiffness changes. Differences and changes of stiffness in professional athletes after acute exercise needed to be considered for diagnosing tendinopathy and injuries. More precise and comparable research protocols in MSK-SWE may be of great benefit for sports medicine but also for rehabilitation and preventive medicine.
Artificial intelligence-based imaging analysis of stem cells: a systematic scoping review protocol
Authors: Issa Julien , Chaar Mazen Abou , Kempisty Bartosz , Mozdziak Paul , Dyszkiewicz-Konwińska Marta
Published: March 2022

Objective: This scoping review aims to map and identify the available artificial intelligence-based imaging analysis of different stem cells types and characterization of stem cells differentiation and transdifferentiation pathways.Introduction: Stem cells are cells that can transform into more specialized cells and include pluripotent, embryonic, and adult subtypes. They are currently receiving huge attention due to the advancing technology of artificial intelligence(AI), a field that has found its way into many disciplines and reaching clinical settings. AI adopts multiple algorithms such as machine learning (ML), and the more useful deep learning (DL) as it provides convolutional neural networks (CNNs) capable of characterizing various stem cell differentiation pathways and classifying images based on their morphology, textures, and physical features thus allowing for future clinical utilization in regenerative medicine.Methods: Five different electronic databases (PubMed, Medline, Web of Science, Cochrane, and Scopus) will be searched, based on a specific searching strategy, for published studies investigating the artificial intelligence-based imaging analysis technique on various types of stem cells. Two independent reviewers will be screening the titles and abstracts of the collected studies, stored in Zotero 5.0, against the inclusion criteria; all potential studies will be subjected to a second examination for the full text before the final decision. Afterward, data will be extracted from the included articles and presented in a table.
Correlation between flooding and settlement planning in Nairobi
Authors: Owuor Martin Ochieng , Mwiturubani Donald Anthony
Published: March 2022

Globally, climate change triggers flooding through unpredictable, intermittent and incessant precipitation. Flooding in Nairobi is multi-factorial in causation. This has raised the question of necessary interventions in the design of urban settlements in order to reduce the impacts of extreme rainfall events that result in floods. This paper seeks to analyse the reciprocal correlation between settlement planning and pluvial flooding in Nairobi. Censuses data were obtained from the Kenya National Bureau of Statistics (KNBS) and daily rainfall records from the Kenya Meteorological Department spanning from 1961 to 2018. Other key parameters were drawn from extensive thematic content analyses of the existing literature. The data were subjected to trend and correlation analyses using the Stata and SPSS software to determine patterns and possible causal relationships. The results showed that there was an insignificant but positive relationship between the two variables with Pearson and Spearman coefficients of correlation of 0.211 and 0.111, respectively. The results of this study repudiate the perceived notion that occurrences of pluvial flooding in Nairobi have increased due to erratic precipitation patterns and improper planning of settlements. The null hypothesis is therefore upheld at 95% confidence level.
Long-term trends and projections of hydrological fluxes under RCP climate change scenarios for a mountainous river catchment of northeast India
Authors: Murasingh S. , Kuttippurath J. , Sandeep Dash S. , Raj S. , Remesan R. , Jha Madan K. , Kumar P.
Published: March 2022

The estimate of changes in hydrological fluxes from a climate change perspective is inevitable for assessing the sustainability of watersheds and conserving water resources. Here, we quantify and assess the changes in different hydrological flux components for the Manu-Deo River Basin (MDRB) of northeast India using Soil and Water Assessment Tool (SWAT) simulations and multi-temporal data at various resolutions. Sequential Uncertainty Fitting (SUFI-2) optimization is used to calibrate and validate the simulations for the periods 1984–2006 and 2007–2016 and for the four future representative concentration pathway (RCP) scenarios. The model performed reasonably well for the calibration and validation of daily data, in accordance with the Nash–Sutcliffe efficiency and coefficient of determination (0.54/0.55 and 0.52/0.72, respectively). The analysis for the period 1985–2013 reveals a decreasing trend in streamflow, which indicates increasing trends of drought there. Furthermore, it shows an increasing trend in evapotranspiration (ET) and decreasing trend for baseflow (BF), suggesting an adverse impact on agricultural production during lean periods. In addition, the RCP 2.6 and 6.0 scenarios for the monsoon season in future time scales are expected to cause a reduction in different flow components, although RCP 8.5 shows increased water availability there. The sub-basin-scale quantification and multi-temporal analysis of water availability under the present and future climate scenarios, as presented here, can assist water managers in formulating a suitable operational policy to implement a better decision-making framework for river and waterbody management. This is particularly important for mountainous regions, where input data are sparse and modelling of hydrological fluxes is challenging.
Desarrollo sustentable: un cisma ambiental y comercial
Authors: Sánchez Mendoza William
Published: March 2022

Es difícil poder discernir sobre la verdadera intención de la estrategia del desarrollo sustentable que ha sido masivamente integrada en las legislaciones de muchos gobiernos y empleada como acervo político en el discurso contemporáneo. Desde los años setenta del siglo pasado, el mundo desarrollado presentó la estrategia que permitiría salvar el planeta de la inminente destrucción a causa de la contaminación y la sobreexplotación de los recursos naturales. Pero los avances en materia ambiental han sido pocos y frecuentemente se nos informa sobre la urgencia de construir una relación equilibrada entre el hombre y su entorno. Mientras tanto, simultáneamente somos arrastrados por un modelo de crecimiento económico e impulsados por la fuerza coercitiva del mercado por su promoción del consumismo. Entonces, no aparenta ser tan claro el sentido de esta importante meta global: crecimiento y desarrollo parecen estar más lejos que cercanos de un posible equilibrio ambiental, entendiendo que vivimos en un planeta finito con recursos materialmente limitados. Sería bueno saber si existe un verdadero compromiso de países ricos por revertir, por ejemplo, el avance del cambio climático, y si el desarrollo sustentable se está convirtiendo en un edulcorante discursivo para tratar de alinear determinados intereses globales.
Curcumin as a Natural Modulator of B Lymphocytes: Evidence from In Vitro and In Vivo Studies
Authors: Haftcheshmeh Saeed Mohammadian , Mohammadi Asadollah , Mashayekhi Kazem , Navashenaq Jamshid Gholizadeh
Published: March 2022

B cells are the only player of humoral immune responses by the production of various types of antibodies. However, B cells are also involved in the pathogenesis of several immune-mediated diseases. Moreover, different types of B cell lymphoma have also been characterized. Selective depletion of B cells by anti-CD20 and other B cell-depleting agents in the clinic can improve a wide range of immune-mediated diseases. B cells' capacity to act as cytokine-producing cells explains how they can control immune cells' activity and contribute to disease pathogenesis. Thus, researchers investigated a safe, low-cost, and effective treatment modality for targeting B cells. In this respect, curcumin, the biologically active ingredient of turmeric, has a wide range of pharmacological activities. Evidence showed that curcumin could affect various immune cells, such as monocytes and macrophages, dendritic cells, and T lymphocytes. However, there are few pieces of evidence about the effects of curcumin on B cells. This study aims to review the available evidence about curcumin's modulatory effects on B cells' proliferation, differentiation, and function in different states. Apart from normal B cells, the modulatory effects of curcumin on B cell lymphoma will also be discussed.
Proton Pump Inhibitors’ Use and Risk of Iron Deficiency Anaemia: A Systematic
Review and Meta-analysis
Authors: Ali Mohammad Daud
Published: March 2022

Aim:

Various research was conducted during the last decade, with inconsistent findings regarding
iron death anaemia (IDA) perils vis-à-vis utilization of proton-pump inhibitors (PPIs). Consequently,
recent systematic review and meta-analysis were implemented to evaluate IDA-related perils
concerning the utilization of proton-pump inhibitors.

Methods:

The databases of EBSCOhost, PubMed® and Cochrane Central were searched from the research
outset until February 28, 2021 purposely to identify all research with objectives that align with
the present research investigation. The Newcastle-Ottawa Scale (NOS) was utilized for the evaluation
of the research investigation standard. The prime (1º) goal of the research was to gauge IDA peril
among users of proton-pump inhibitors (PPI). For data processing, RevMan (Review Manager) version
5.4 was employed.

Results:

In total, fourteen investigations research was employed in this systematic review and metaanalysis.
The combined relative risk of nine research exhibited a numerically consequential interrelation
betwixt the utilization of proton-pump inhibitors and IDA peril (RR 2.56 [95% CI 1.43–4.61], p <
0.00001). Contemporary systematic review and meta-analysis examination posit that proton-pump inhibitor
consumers are prone to greater peril of coming down with IDA in comparison to non-PPI users.

Conclution:

In keeping with the findings of my research, prescriber physicians should exercise caution
when prescribing PPIs to individuals taking it for a long time to avoid the peril of IDA. Additionally,
their serum iron level should be checked to ensure that proton-pump inhibitors are safe.
Recent Trends in Surface Cladding on AISI 1045 Steel Substrate: A Review
Authors: Alam M.S.
Published: March 2022

Abstract. This paper gives the informative review and enlighten the important characteristics and development of different cladding techniques applied on AISI 1045 medium carbon steel substrate material. The paper focuses on the cladding methods used on AISI 1045 steel follows the way of surfacing via fusion. The cladding practice like wire feed, powder blown are taken into consideration. Different cladding methods such as Tungsten Inert Gas (TIG) Arc cladding, thermal spraying, laser cladding and electron beam cladding has been compared for better understanding. The application of various cladding powders by TIG cladding technique on AISI 1045 steel substrate material is presented by exhaustive critical review of various research papers of the era. The importance of TIG cladding process has been discussed.
The implementation of community development participation (KKN) based literacy education in Central Lombok
Authors: Rizka Muhammad Arief , Sukri Akhmad , Permana Dira
Published: March 2022

This study aimed at analyzing the implementation of Thematic Community Service Program (KKN)-based basic literacy education of IKIP Mataram in the Central Lombok District which included registration, debriefing, implementation, monitoring, evaluation, and identification of the obstacles to implementation in the field. The research method used in this research was a descriptive method by combining quantitative and qualitative approaches. The subjects of this study were the Chairperson of Institute for Research and Community Service (LPPM) IKIP Mataram, the Organizing Committee, Community Service Students, Field Counseling Lecturers, Village Heads, and Literacy Education Students. Data collection instruments used were questionnaires, interviews, observation, and documentation guidelines. The data analysis technique used was qualitative and quantitative descriptive analysis. The results of this study showed that; (1) the implementation of basic literacy education based Thematic Community Service (KKN) Program at IKIP Mataram has been carried out through the stages of registration, debriefing, implementation, monitoring, and evaluation; (2) The results of the evaluation of the implementation of Basic Literacy Education learning have succeeded in teaching 802 illiterate people in Central Lombok district with data on the results of the basic literacy tests that have been carried out as many as 552 people have learned and declared passed and as many as 250 people declared not passed or do not yet meet the Minimum Completeness Criterion (KKM) of Basic Literacy Assessment; and (3) The main obstacle of the implementation of the Thematic KKN program is the earthquake disaster that struck the island of Lombok and has implications on the minimum residents basic literacy learning implementation in the field. However, Community Service (KKN) students with DPL assistance, the Village Head, and the LPPM Team have made an optimal effort so that the implementation of the Thematic KKN can continue to run in the community.
Peningkatan pengetahuan dan keterampilan pengelola bank sampah melalui sistem cerdas komunikasi pemasaran
Authors: Rozalena Agustin
Published: March 2022

Munculnya keraguan dari masyarakat dalam mengelola bank sampah di Desa Sumbersari, Kecamatan Ciparay, Kabupaten Bandung sejauh ini dikarenakan masih terbatasnya pengetahuan dan pemahaman pengelolaan bank sampah secara umum. Informasi pengolahan sampah masih belum dianggap sebagai “sahabat” dalam menjaga kebersihan, lebih bermanfaat dan memiliki dampak ekonomi bagi hidup masyarakat. Salah satu alternatif dalam mendukung program penguatan bank sampah melalui peningkatan pengetahuan, pemahaman serta dukungan keterampilan di bidang komunikasi pemasaran. Bagi pengelola bank sampah, kegiatan ini dapat meningkatkan kemampuan komunikasi pemasaran dalam upaya lebih kreatif menyampaikan manfaat bank sampah dan prospek pemasaran sampah. Metoda pelaksanaan dalam mewujudkan program peningkatkan pengetahuan dan keterampilan pengelola bank sampah melalui metode penyuluhan terintegrasi dan pelatihan secara sistematis. Hasil pengabdian menunjukkan pengelola semakin memahami dan terampil dalam menerapkan praktik komunikasi pemasaran bank sampah kepada calon nasabah. Pengelola bank sampah lebih percaya diri dalam mengemban program kebersihan dan manfaat sampah ini, sehingga harapan masyarakat yang “bersahabat” dengan sampah dan kepedulian terhadap desa berbasis ecovillage dapat terwujud. Improvement of knowledge and skill of waste bank officers through marketing communication smart systems AbstractThe emergence of doubts from the community in managing the waste bank in Sumbersari Village, Ciparay District, Bandung Regency so far is due to the limited knowledge and understanding of waste bank management in general. Information about waste management is not yet considered as a "friend" in maintaining cleanliness, is more useful and has an economic impact on people's lives. One alternative is to support the garbage bank strengthening program through increased knowledge, understanding and skills support in the field of marketing communication. For officers, this activity can improve marketing communication skills in a more creative effort to convey the benefits of waste banks and the prospects for waste marketing. Implementation method in realizing the program to improve the knowledge and skills of waste bank officers through integrated counselling methods and systematic training. The results of the dedication show that officers are increasingly understanding and skilled in applying the practice of marketing communications of the waste bank to prospective customers. The officers are more confident in carrying out the cleanliness program and the benefits of this waste so that the hope of people who are "friendly" to waste and concern for the village based on ecovillage can be realized.
Pemberdayaan ekonomi kreatif berbasis kearifan lokal masyarakat dengan pendekatan outcome mapping
Authors: Sanuri Sanuri
Published: March 2022

Penelitian ini bertujuan untuk mengetahui penerapan pendekatan outcome mapping pada proses  pemberdayaan ekonomi kreatif berbasis kearifan lokal masyarakat di kampung Kais-Tapuri, Distrik Kais, Kabupaten Sorong selatan, Papua barat. Penelitian ini merupakan penelitian  participatory action research dengan menggunakan pendekatan kualitatif dan kuantitatif. Subjek penelitian terdiri dari 20 perempuan usia produktif. Data penelitian diperoleh dengan teknik observasi, wawancara, dan dokumentasi. Hasil penelitian adalah sebagai berikut: (1) Perencanaan partisipatoris untuk identifikasi kebutuhan terkait ekonomi rumah tangga bersama dengan kepala kampung, aparat kampung,  perwakilan perempuan di dua kampung  (2) Penentuan mitra langsung dan stakeholder potensial, mitra langsung yang terpilih terdiri dari 20 perempuan usia produktif dari dua kampung, dan stakeholder potensial terdiri dari kepala kampung, pendeta, kepala suku, dan kader posyandu  (3) Desain program yaitu berupa rancangan terarah yang terdiri dari: visi dan misi, mitra langsung, capaian dambaan, penanda kemajuan (4) Menentukan rencana kerja berupa pelatihan dan pendampingan (5) Indikator keberhasilan pelatihan adalah adanya perubahan perilaku mitra langsung yang dapat dilihat pada penanda kemajuan yang sudah dibuat selama semester pertama Creative economy empowerment based on community local wisdom with outcome mapping approach AbstractThis research aims to determine the application of the outcome mapping approach to the process of creating economic empowerment based on local wisdom in the Kais-Tapuri village, Kais District, South Sorong Regency, West Papua. This research is participatory action research with qualitative and quantitative approaches. The research subjects consisted of 20 productive age women (housewives). The research data were obtained through observation, interview, and documentation techniques. The results of the research were as follows: (1) Participatory planning consisted of identifying needs related to household economics together with village heads, village officials, women representatives in two villages (2) Determination of Boundary partners and potential stakeholders, selected Boundary partners consisting of 20 women productive age of two villages, and potential stakeholders consist of village heads, pastors, chiefs, and Posyandu cadres (3) Program design is an intentional design consisting of vision and mission, boundary partners, Outcome challenges, progress marker (4) Determine work plans in the form of training and assistance (5) Indicators of successful training are changes in the behaviour of boundary partners that can be seen in the marker of progress made during the first semester
Model GELPITAS (gerak & lagu, picture & picture, talking stick) untuk meningkatkan perkembangan bahasa Inggris anak taman kanak-kanak
Authors: Purwanti Ratna , Suhaimi Suhaimi
Published: March 2022

Tujuan Penelitian ini untuk mendeskripsikan motivasi dan aktivitas siswa serta hasil perkembangan bahasa inggris anak dengan menggunakan Gelpitas, karena pentingnya Bahasa Inggris untuk anak usia dini di masa emas agar dapat bersaing di dunia global ketika mereka beranjak dewasa nanti. Penelitian ini menggunakan pendekatan kualitatif dengan jenis penelitian yaitu Penelitian Tindakan Kelas (PTK) dalam empat pertemuan. Hasil penelitian menunjukan bahwa motivasi anak meningkat dan aktivitas anak secara klasikal dengan kategori sangat aktif. Hasil kemampuan anak mencapai ketuntasan klasikal dengan berkembang sangat baik dan telah memenuhi indikator keberhasilan. Dapat disimpulkan bahwa melalui Gelpitas (gerak dan lagu, model picture and picture, model Talking Stick) dapat meningkatkan kemampuan anak dalam perkembangan bahasa (Bahasa Inggris) pada anak Kelompok B Taman Kanak-kanak. GELPITAS model (gerak lagu, picture picture, talking stick) to improve development English early childhood AbstractThe purpose of this research is to describe student motivation and activities, the results of students' English development using Gelpitas, because of the importance of English for early childhood in the golden age to be able to compete in the global world when they grow up later. This study uses a qualitative approach to the type of research that is Classroom Action Research (CAR) in four meetings. The result shows that children motivation increases and the classical activities of children with a very active category. The results of children's ability to achieve classical completeness by developing very well and have met the indicators of success. It can be concluded that through Gelpitas (motion and song, picture and picture model, Talking Stick model) can improve children's ability in language development (English) in Group B Kindergarten children.
Survei Aksesibilitas Fisik dan Sosial sebagai Dasar Penyusunan Grand Design Desa Inklusif
Authors: Hanjarwati Astri , Suprihatiningrum Jamil , Aminah Siti
Published: March 2022

Abstrak: Desa Trimurti memiliki jumlah penyandang disabilitas tertinggi di Kabupaten Bantul. Hal ini menjadikan Desa Trimurti berpotensi untuk  menjadi desa inklusif. Penelitian ini bertujuan untuk mengetahui aksesibilitas fisik dan sosial penyandang disabilitas. Metode penelitian yang digunakan adalah penelitian survei, dengan sampel 60 penyandang disabilitas (30% dari total jumlah penyandang disabilitas). Analisis data secara deskriptif menggunakan spss versi 23. Hasilnya survei  menunjukkan: (1) aksesibilitas sosial di Desa Trimurti sangat baik ditunjukkan dengan sikap terhadap penyandang disabilitas yang baik; ketersediaan layanan pendidikan, kesehatan dan informasi sangat baik. (2) aksesibilitas fisik menunjukkan bahwa  sebagian besar bangunan fisik tidak dapat diakses, kecuali Sekolah Khusus (SLB) dan Puskesmas Srandakan. (3)  aksesibilitas finansial, kebijakan dan pengetahuan para penyandang cacat masih sangat terbatas; penyandang disabilitas tidak memiliki akses ke modal dan peluang kerja. Berdasarkan pada hasil survei tersebut dapat disusun kebijakan yang inklusif sehingga terwujud desa inklusif yang ramah terhadap penyandang disabilitas Survey of Physical and Social Accessibility as a Base Preparation of the Inclusive Village Grand Design Abstract: Trimurti Village has the highest number of persons with disabilities in Bantul Regency. This makes Trimurti Village has the potential to become an inclusive village. This study aims to determine the physical and social accessibility of persons with disabilities. The research method used was survey research, with a sample of 60 people with disabilities (30% of the total number of people with disabilities). Descriptive data analysis using SPSS version 23. The survey results show: (1) social accessibility in the village of Trimurti is very well demonstrated by a good attitude towards persons with disabilities; the availability of education, health and information services is very good. (2) physical accessibility shows that most of the physical buildings are inaccessible, except for Special Schools (SLB) and the Heatlh Center (Puskesmas) Srandakan. (3) financial accessibility, policy and knowledge of people with disabilities is still very limited; people with disabilities do not have access to capital and employment opportunities. Based on the results of the survey, inclusive policies can be developed so that an inclusive village that is friendly to people with disabilities can be developed.