bluuebunny/crossref_metadata_2025 huggingface dataset:
Relationships between Alternative Nurse Staffing Level Measurements and Nurses’ Perceptions of Nurse Staffing Level Adequacy, Fatigue, and Care Quality
Authors: Hong Kyung Jin , Chung Hyesook , Jo Young Mi
Published: August 2023

Aims. This study examined the influence of nurse staffing level, measured using various methods, on nurses’ perceived adequacy of nurse staffing level, fatigue, and nursing care quality. Background. Although previous studies have recommended various methods of measuring nurse staffing level, there is a lack of research that compares different measurement methods or considers nurses’ perceptions of staffing level on a daily basis. Methods. We conducted a cross-sectional study using work sampling and the questionnaire method in a general hospital in South Korea from July 18 to August 14, 2022. Results based on responses from 90 nurses and scores of 5,536 inpatients derived from the Korean Patient Classification System were included in the analysis. Results. The average nurse-to-patient ratio a day was 1 : 3.20, and the registered nursing hours per patient day was 2.35. Perceived insufficient nurse staffing and fatigue were higher on weekdays than on weekends (

p
<
0.001

). All variables measuring the nurse staffing level affected the nurses’ perceived inadequacy of nurse staffing level, fatigue, and nursing care quality, compared to other variables related to nurse staffing level, such as work intensity and demanding nursing hours per nurse (R2: 0.19–0.31), the nurse-to-patient ratio had the lowest explanatory power in explaining the nurses’ perceptions (R2: 0.14–0.18). Conclusions. Nurse staffing level measurement should consider the acuity of inpatients and nursing care time. Further research is needed to utilize nurses’ perceptions of the appropriate nurse staffing level. Implications for Nursing Management. Efforts are required to maintain an appropriate nurse staffing level through continuous monitoring of nurses’ perceptions and acuity of inpatients to preserve nurses’ alertness during work and improve nursing care quality.
Composite Dietary Antioxidant Index Is Negatively Associated with Hyperuricemia in US Adults: An Analysis of NHANES 2007–2018
Authors: Lin Zhenzong , Chen Haokai , Lan Qiwen , Chen Yinghan , Liao Wanzhe , Guo Xuguang
Published: August 2023

Hyperuricemia and its complications are severe risks to human health. Dietary intervention is considered an essential part of the management of hyperuricemia. Studies have reported that the intake of antioxidants has a positive effect on hyperuricemia. Here, we collected data from 8761 participants of the National Health and Nutrition Examination Survey for this analysis. Daily intakes of vitamins A, C, and E; manganese; selenium; and zinc were calculated as the composite dietary antioxidant index (CDAI). The participants were divided into four groups (Q1, Q2, Q3, and Q4) according to the CDAI. Univariate analysis was used to assess the association of covariates with hyperuricemia. The association between the CDAI and hyperuricemia was evaluated using multinomial logistic regression, and its stability was determined by stratified analysis. Our results revealed that the CDAI has a significant negative association with hyperuricemia (Q2: 0.81 (0.69, 0.95); Q3: 0.75 (0.62, 0.90); Q4: 0.65 (0.51, 0.82);

P
<
0.01

). The results of stratified analysis emphasize that this association between CDAI and hyperuricemia is stable. In conclusion, this study suggested a negative association between the CDAI and hyperuricemia.
Table S1 from Activator Protein-1 (AP-1) Signaling Inhibits the Growth of Ewing Sarcoma Cells in Response to DNA Replication Stress
Authors: Croushore Emma E. , Koppenhafer Stacia L. , Goss Kelli L. , Geary Elizabeth L. , Gordon David J.
Published: August 2023

Gene set enrichment analysis of genes up- and down-regulated in the EW8-RRM1-KO cells after removal of doxycycline.
TABLE 1 from Activator Protein-1 (AP-1) Signaling Inhibits the Growth of Ewing Sarcoma Cells in Response to DNA Replication Stress
Authors: Croushore Emma E. , Koppenhafer Stacia L. , Goss Kelli L. , Geary Elizabeth L. , Gordon David J.
Published: August 2023

Increase in mRNA expression levels of AP-1 family members in RRM1-KO cell lines after removal of doxycycline and loss of the RRM1 protein
FIGURE 5 from Activator Protein-1 (AP-1) Signaling Inhibits the Growth of Ewing Sarcoma Cells in Response to DNA Replication Stress
Authors: Croushore Emma E. , Koppenhafer Stacia L. , Goss Kelli L. , Geary Elizabeth L. , Gordon David J.
Published: August 2023

HDAC inhibitors decrease the level of the RRM1 protein and increase expression of c-Jun in Ewing sarcoma cells. A, EW8 and TC71 cell lines were treated with the dual PI3K-HDAC inhibitor fimepinostat for 24 hours and then cell lysates were collected for immunoblotting. B, Dose–response curves for Ewing sarcoma cell lines treated with different concentrations of fimepinostat for 72 hours. Cell viability was assessed using the AlamarBlue Fluorescence Assay. The results are representative of two independent experiments. Error bars represent mean ± SD of three technical replicates. C, Ewing sarcoma (EW8 and TC71) and osteosarcoma (U2OS) cell lines were treated with the HDAC inhibitors panobinostat or romidepsin for 24 hours and then cell lysate was collected for immunoblotting. D, log2 fold change (FC) in RRM1 mRNA in EW8 and TC71 cells treated with panobinostat or romidepsin for 24 hours. The results are representative of two independent experiments. Error bars represent the mean ± SD of three technical replicates. E, EW8 and TC71 cells were treated with panobinostat, romidepsin, or fimepinostat for 24 hours and then cell lysates were collected for immunoblotting. F, Ewing sarcoma cell lines were treated with romidepsin for 24 hours and then cell lysates were collected for immunoblotting.
FIGURE 2 from Activator Protein-1 (AP-1) Signaling Inhibits the Growth of Ewing Sarcoma Cells in Response to DNA Replication Stress
Authors: Croushore Emma E. , Koppenhafer Stacia L. , Goss Kelli L. , Geary Elizabeth L. , Gordon David J.
Published: August 2023

Loss of RRM1 activates AP-1 signaling in Ewing sarcoma cells. Volcano plots of DE genes (fold >2, adjusted P value <0.05) in the EW8-RRM1-KO (A) and TC71-RRM1-KO (B) cell lines in the presence and absence (48 hours) of doxycycline. C, Gene sets (biological processes) enriched in the 412 overlap genes that are upregulated in both the EW8-RRM1-KO and TC71-RRM1-KO cell lines in the absence of doxycycline. D, Results of TFEA performed with the overlap genes that are upregulated in both the EW8-RRM1-KO and TC71-RRM1-KO cell lines in the absence of doxycycline. E, EW8-RRM1-KO cells were treated with different concentrations of doxycycline for 48 hours and then cellular lysates were collected for immunoblotting. F, Doxycycline was removed from the EW8-RRM1-KO and TC71-RRM1-KO cell lines and lysates were collected at different timepoints. G, Doxycycline was removed from the EW8-RRM1-KO and TC71-RRM1-KO cells for 48 hours. Cell lysates were then collected for immunoblotting for total and phosphorylated (Ser73) c-Jun. H, EW8-RRM1-KO and TC71-RRM1-KO cells were grown with or without doxycycline for 48 hours. Subcellular fractionation was then performed and lysates were immunoblotted for c-Jun and markers of the nuclear (α-Tubulin) and cytoplasmic (Lamin A/C) fractions. The parental, unmodified EW8 and TC71 cells were treated with a range of gemcitabine (I) or hydroxyurea doses (J) for 24 hours and then cell lysates were collected for immunoblotting. K, EW8 cells labeled with an AP-1 (luciferase) reporter were used to quantify AP-1 activity when cell lines were treated with gemcitabine or hydroxyurea for 24 hours. TC71 (L) and EW8 (M) cells were engrafted in nude (NCr) mice. After tumors were palpable, the mice were treated with vehicle or gemcitabine (150 mg/kg, intraperitoneal, day 1). On day 2, the mice were sacrificed and the tumors were collected for analysis by immunoblotting. P values were calculated using a two-tailed Student t test or a one-way ANOVA followed by Dunnett multiple comparisons test. **, P < 0.01.
Data from Activator Protein-1 (AP-1) Signaling Inhibits the Growth of Ewing Sarcoma Cells in Response to DNA Replication Stress
Authors: Croushore Emma E. , Koppenhafer Stacia L. , Goss Kelli L. , Geary Elizabeth L. , Gordon David J.
Published: August 2023

Ribonucleotide reductase (RNR) catalyzes the rate-limiting step in the synthesis of deoxyribonucleosides and is required for DNA replication. Multiple types of cancer, including Ewing sarcoma tumors, are sensitive to RNR inhibitors or a reduction in the levels of either the RRM1 or RRM2 subunits of RNR. However, the polypharmacology and off-target effects of RNR inhibitors have complicated the identification of the mechanisms that regulate sensitivity and resistance to this class of drugs. Consequently, we used a conditional knockout (CRISPR/Cas9) and rescue approach to target RRM1 in Ewing sarcoma cells and identified that loss of the RRM1 protein results in the upregulation of the expression of multiple members of the activator protein-1 (AP-1) transcription factor complex, including c-Jun and c-Fos, and downregulation of c-Myc. Notably, overexpression of c-Jun and c-Fos in Ewing sarcoma cells is sufficient to inhibit cell growth and downregulate the expression of the c-Myc oncogene. We also identified that the upregulation of AP-1 is mediated, in part, by SLFN11, which is a replication stress response protein that is expressed at high levels in Ewing sarcoma. In addition, small-molecule inhibitors of RNR, including gemcitabine, and histone deacetylase inhibitors, which reduce the level of the RRM1 protein, also activate AP-1 signaling and downregulate the level of c-Myc in Ewing sarcoma. Overall, these results provide novel insight into the critical pathways activated by loss of RNR activity and the mechanisms of action of inhibitors of RNR.
Significance:
RNR is the rate-limiting enzyme in the synthesis of deoxyribonucleotides. Although RNR is the target of multiple chemotherapy drugs, polypharmacology and off-target effects have complicated the identification of the precise mechanism of action of these drugs. In this work, using a knockout-rescue approach, we identified that inhibition of RNR upregulates AP-1 signaling and downregulates the level of c-Myc in Ewing sarcoma tumors.
Relative Remission and Low Disease Activity Rates of Tofacitinib, Baricitinib, Upadacitinib, and Filgotinib versus Methotrexate in Patients with Disease-Modifying Antirheumatic Drug-Naive Rheumatoid Arthritis
Authors: Lee Young Ho , Song Gwan Gyu
Published: August 2023

Background: The relative efficacy of Janus kinase (JAK) inhibitors in producing remission and low disease activity (LDA) states remains unknown since there are currently no trials that provide direct comparisons among JAK inhibitors in disease-modifying antirheumatic drug (DMARD)-naive patients with rheumatoid arthritis (RA). Objectives: This study aimed to assess the relative remission and LDA rates of tofacitinib, baricitinib, upadacitinib, and filgotinib compared to those of methotrexate (MTX) in DMARD-naive patients with RA. Method: We conducted Bayesian network meta-analysis and included information from direct and indirect comparisons from randomized controlled trials that examined remission (Disease Activity Score in 28 Joints using C-reactive protein level [DAS28-CRP] <2.6) and LDA (DAS28-CRP ≤ 3.2) produced by tofacitinib, baricitinib, upadacitinib, filgotinib monotherapy, and MTX in patients with DMARD-naive RA. Results: Four randomized controlled trials, comprising 2,185 patients, met the inclusion criteria. This network meta-analysis showed that treatment with tofacitinib, baricitinib, upadacitinib, and filgotinib achieved a significantly higher remission rate than that with MTX (odds ratio [OR] = 4.13, 95% CI = 2.88–6.02; OR = 2.12, 95% CI = 1.17–4.13; OR = 1.95, 95% CI = 1.10–3.50; OR = 1.79, 95% CI = 1.27–3.53). The ranking probability based on the surface under the cumulative ranking curve indicated that upadacitinib 15 mg had the highest probability of achieving remission (SUCRA = 0.985), followed by tofacitinib 5 mg (SUCRA = 0.574), baricitinib 4 mg (SUCRA = 0.506), filgotinib 200 mg (SUCRA = 0.431), and MTX (SUCRA = 0.004). Moreover, treatment with tofacitinib, baricitinib, upadacitinib, and filgotinib achieved significantly higher LDA rate than that with MTX. The ranking probability for LDA was similar to that for remission; upadacitinib 15 mg had the highest probability of achieving LDA, followed by tofacitinib 5 mg, baricitinib 4 mg, filgotinib 200 mg, and MTX. Conclusions: Upadacitinib seems to be one of most effective interventions for achieving remission and LDA in DMARD-naive patients with RA based on the comparative analysis, and there are differences in remission and LDA rates induced by different JAK inhibitors.
Toninha: um pequeno cetáceo ameaçado de extinção
Authors:   Universidade de São Paulo. Instituto Oceanográfico, Domingues Isabela Rugitsky , Santos Marcos César de Oliveira ,   Universidade de São Paulo. Instituto Oceanográfico
Published: August 2023

Este livro apresenta a toninha, a espécie de golfinho mais ameaçada de extinção do Atlântico Sul. Inclui uma revisão dos conhecimentos sobre a espécie, e uma recomendação de caminhos a seguir que podem retirar a toninha do caminho da extinção. Em síntese, este documento trata de uma revisão bibliográfica atualizada sobre o estado atual de conhecimentos sobre a toninha, um pequeno golfinho sob forte ameaça de extinção, e que ocorre apenas em três países da América do Sul: o Brasil, o Uruguai e a Argentina. A meta dos autores é que este material, produzido em língua portuguesa e de livre acesso, tenha um alcance maior e mais efetivo a membros da sociedade não acadêmica sul-americana, quando comparado à considerável carga de documentos científicos produzidos até aqui, em parte listada ao final deste documento, e que está inacessível a quem não é cientista; ou pelo fato dessa literatura ser quase que exclusivamente escrita em língua inglesa, ou por estar disponível apenas em meios que somente os cientistas foram capacitados e autorizados a procurar e a acessar. Escrito em uma linguagem mais compreensível a não acadêmicos, mas mantendo a estrutura de apresentação corriqueira de trabalhos escritos por cientistas para familiarizar a comunidade não cientista a essa estrutura textual, poderá alcançar uma maior audiência; preferencialmente aqueles atores da sociedade que não podem ser deixados de lado no árduo desafio de lutar pela conservação deste indefeso golfinho.
Estudo transversal sobre o quadro de sequelas neurológicas nos pacientes com COVID-19 na região da AMREC e AMESC de Santa Catarina
Authors: Assunção Jean Murilo Patrício da , Raupp Tomas Alisson Marques , Mazon Josete , Tarabay Fernando Topanotti
Published: August 2023

INTRODUÇÃO: COVID-longa refere-se ao grupo de sintomas que persistem após um mês da fase aguda da doença. Destacam-se fadiga, dispneia, alterações sensoriais, mialgia e alterações cognitivas como as principais manifestações observadas. OBJETIVO: Analisar o cenário das sequelas neurológicas associadas ao COVID-19 nas regiões da Associação de Municípios do Extremo Sul Catarinense (AMESC) e Associação dos Municípios da Região Carbonífera (AMREC) de Santa Catarina. MÉTODO: Participaram da pesquisa 541 pacientes infectados que não se encontravam na fase aguda da doença. Por meio da entrevista telefônica estruturada, foram obtidos dados referentes aos sintomas e à realização de tratamento desses pacientes. RESULTADOS: Constatou-se que 71,7% dos pacientes entrevistados relataram sintomas de COVID-longa, principalmente entre as mulheres (65,4%). Alterações cognitivas (41,8%), anosmia (33,3%), alterações do paladar (27,4%) foram as manifestações neurológicas de COVID-longa mais frequentes entre os participantes nas duas regiões pesquisadas. Demonstrou-se relação significativa entre a duração do distúrbio do sono na AMREC e AMESC (p = 0,014), assim como na realização de tratamento na AMESC e não realização de tratamento na AMREC (p < 0,001). CONCLUSÃO: Dentre as manifestações neurológicas, houve maior frequência de alterações cognitivas, anosmia e alterações do paladar entre os indivíduos das duas regiões estudadas. Além disso, a procura por realização de tratamento em ambiente domiciliar, atenção básica e especializada na região na AMESC, bem como a não realização de tratamento na AMREC, demonstrou significativa diferença entre os cenários regionais. Assim também, a duração de distúrbios do sono, com apresentação mais frequente durante a fase aguda na AMESC e a fase crônica na AMREC, apresentou relevante distinção constatada entre os participantes das duas regiões, sugerindo a realização de estudos mais completos e prolongados nessas populações.
Educação Permanente em Saúde na atenção primária: percepções de trabalhadores sobre conceito e prática
Authors: Silva Carolina Luiz Ferreira da , Jorge Tatiane Martins
Published: August 2023

O presente estudo pretendeu investigar como equipes de saúde da atenção primária à saúde percebem o significado da Educação Permanente em Saúde (EPS) e como a prática tem ocorrido em suas realidades. Participaram do estudo duas equipes da Atenção Primária à Saúde (APS) escolhidas por meio de sorteio, sendo uma Equipe Saúde da Família (eSF) e outra Equipe de Atenção Primária (eAP) em um município no interior do estado de São Paulo. Os participantes foram trabalhadores da saúde compreendendo os profissionais de nível superior e nível médio de cada equipe. O instrumento utilizado para coleta foi um questionário online formado por catorze questões divididas em duas partes, sendo uma destinada às informações do perfil profissional e a segunda parte voltada para questões relevantes ao estudo. A aplicação do questionário se deu no último bimestre do ano de 2020. O material coletado foi reunido e analisado pela técnica de análise de conteúdo temática descrita por Bardin e Minayo. A partir dos grandes temas do estudo, “Conhecimento” e “Prática de EPS”, o material permitiu a identificação de três núcleos de significação, sendo eles: “EPS como Educação Continuada”, “Desafios institucionais e pessoais para a mudança” e “Apoio da gestão e movimento da própria equipe”. Compreendendo as limitações do estudo quanto ao tamanho da amostra e instrumento utilizado para coleta de dados, os resultados trazem homogeneidade com estudos já publicados. Equipes da Atenção Primária à Saúde enfrentam confusão no significado de EPS no desenvolvimento de práticas voltadas à proposta da Educação Continuada, onde consequentemente observa-se o enfrentamento de barreiras no planejamento da prática de EPS. Da mesma forma, vê-se similaridade aos resultados encontrados no estudo com a literatura no que diz respeito ao engajamento das equipes em fazer a prática acontecer.
Systolic Blood Pressure Time in Target Range and Incident Atrial Fibrillation in Patients With Hypertension: Insights From the SPRINT Trial
Authors: Wang Jue , Jiang Chao , Li Sitong , Wang Zhiyan , Wang Yufeng , Lai Yiwei , Wang Zhen , Lv Wenhe , Bai Yu , Yang Zejun , Guo Qi , Huang Lihong , He Liu , Guo Xueyuan , Li Songnan , Liu Nian , Jiang Chenxi , Tang Ribo , Long Deyong , Du Xin , Sang Caihua , Dong Jianzeng , Ma Changsheng
Published: August 2023

BACKGROUND:

Systolic blood pressure (SBP) time in target range (TTR) indicates the mean value, exposure time, and variability in blood pressure over time. The prognostic value of SBP TTR for incident atrial fibrillation (AF) in patients with hypertension is unclear.

METHODS:

We performed a post hoc analysis of SPRINT (Systolic Blood Pressure Intervention Trial), a randomized controlled trial comparing intensive (<120 mm Hg) and standard (<140 mm Hg) SBP interventions in participants with hypertension. SBP target ranges for intensive and standard arms were defined as 110 to 130 and 120 to 140 mm Hg, respectively. TTR was calculated by linear interpolation method using SBP from months 0 to 3. We used Cox proportional regression models to assess the association of SBP TTR with incident AF.

RESULTS:

Among 7939 participants included in this analysis, 187 incident AF cases occurred during follow-up. After multivariable adjustment, a 10% increase in SBP TTR was independently associated with a 7% lower risk of incident AF (hazard ratio, 0.93 [95% CI, 0.88–0.97];
P
=0.003). The restricted spline curve depicted a linear and inverse relationship between SBP TTR and incident AF. Sensitivity analyses generated consistent results when calculating TTR over a longer period or setting target range as 110 to 140 mm Hg for the whole population.

CONCLUSIONS:

Higher SBP TTR independently predicts a lower risk of incident AF. Efforts to attain SBP within 110 to 140 mm Hg over time may be an effective strategy to prevent AF.

REGISTRATION:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT01206062.
Impact of Marital Stress on 1‐Year Health Outcomes Among Young Adults With Acute Myocardial Infarction
Authors: Zhu Cenjing , Dreyer Rachel P. , Li Fan , Spatz Erica S. , Caraballo‐Cordovez César , Mahajan Shiwani , Raparelli Valeria , Leifheit Erica C. , Lu Yuan , Krumholz Harlan M. , Spertus John A. , D'Onofrio Gail , Pilote Louise , Lichtman Judith H.
Published: August 2023

Background

Stress experienced in a marriage or committed relationship may be associated with worse patient‐reported outcomes after acute myocardial infarction (AMI), but little is known about this association in young adults (≤55 years) with AMI.

Methods and Results

We used data from VIRGO (Variation in Recovery: Role of Gender on Outcomes of Young AMI Patients), an observational cohort study that enrolled individuals aged 18 to 55 years with AMI (2008–2012). Marital stress was self‐reported 1 month after AMI using the Stockholm Marital Stress Scale (categorized as absent/mild, moderate, and severe). Outcomes were physical/mental health (Short Form‐12
)
, generic health status (EuroQol‐5 Dimensions), cardiac‐specific quality of life and angina (Seattle Angina Questionnaire), depressive symptoms (Patient Health Questionnaire‐9), and all‐cause readmission 1 year after AMI. Regression models were sequentially adjusted for baseline health, demographics (sex, age, race or ethnicity), and socioeconomic factors (education, income, employment, and insurance). Sex and marital stress interaction was also tested. Among 1593 married/partnered participants, 576 (36.2%) reported severe marital stress, which was more common in female than male participants (39.4% versus 30.4%,
P
=0.001). Severe marital stress was significantly associated with worse mental health (beta=−2.13, SE=0.75,
P
=0.004), generic health status (beta=−3.87, SE=1.46,
P
=0.008), cardiac‐specific quality of life (beta=−6.41, SE=1.65,
P
<0.001), and greater odds of angina (odds ratio [OR], 1.49 [95% CI, 1.06–2.10],
P
=0.023) and all‐cause readmissions (OR, 1.45 [95% CI, 1.04–2.00],
P
=0.006), after adjusting for baseline health, demographics, and socioeconomic factors. These associations were similar across sexes (
P
‐interaction all >0.05).

Conclusions

The association between marital stress and worse 1‐year health outcomes was statistically significant in young patients with AMI, suggesting a need for routine screening and the creation of interventions to support patients with stress recovering from an AMI.
Five new species of Eiphosoma Cresson, 1865 (Ichneumonidae: Cremastinae) from Colombia, new records, and a key to Colombian species
Authors: CUÉLLAR-RAMÍREZ MAURICIO , RAMOS-PASTRANA YARDANY , FERNANDES DANIELL R. R.
Published: August 2023

A taxonomic study of the species of the Darwin wasp genus Eiphosoma Cresson, 1865 (Hymenoptera: Ichneumonidae: Cremastinae) from the department of Caquetá, Colombia, resulted in five new species being described: E. caqueta sp. nov. (Type locality: Curillo, Caquetá), E. eneke sp. nov. (Type locality: San Vicente del Caguán, Caquetá) E. interpunctum sp. nov. (Type locality: Solano, Caquetá,), E. rumi sp. nov. (Type locality: Florencia, Caquetá) and E. sinecarenatum sp. nov. (Type locality: Florencia, Caquetá). With this paper, the number of Eiphosoma species from Colombia increases from three to 16. Eiphosoma bogan Gauld, 2000; E. dentator (Fabricius, 1804); E. dolopon Gauld, 2000; E. fluminense Costa Lima, 1953; E. fuzhi Gauld, 2000; E. macrum (Enderlein, 1921); E. minense Costa Lima, 1953 and E. tantalium Gauld, 2000 are recorded for the first time from Colombia. A dichotomous key to the Colombian species is presented.
An illustrated guide to lady beetles (Coleoptera: Coccinellidae) of the Indian Subcontinent. Part 1. Tribe Coccinellini
Authors: POORANI J.
Published: August 2023

An illustrated guide to the tribe Coccinellini (Coleoptera: Coccinellidae: Coccinellinae) of the Indian Subcontinent comprising 119 species of 30 genera is presented. Brief diagnostic accounts of the genera and the species included therein are given with supporting illustrations of diagnostic characters, including genitalia, wherever available. Details of distribution, prey and plant associations, and seasonal occurrence are provided based on collections, label data and literature. For 31 species, illustrations of the life stages are included to facilitate the field identification of the immature stages. Adalia puetzi Iablokoff-Khnzorian, 1986 is synonymized with Adalia simmondsi Kapur & Sudha Rao, 1962 (new synonym). Oenopia smetanai Canepari, 1997 is removed from synonymy with O. flavidbrunna Jing, 1986 and restored as a valid species (status revised). Illeis kapuri Anand, Gupta & Ghai is transferred to Ortalia Mulsant, 1850 (new combination). Two new species, Harmonia andamanensis sp. n. and Phrynocaria prathapani sp. n. are described and illustrated from the Andamans and the Western Ghats, respectively. Coelophora lushuiensis (Jing, 1992) is documented as a new record for India (Manipur). An updated checklist of the Coccinellini of the Indian Subcontinent is also provided.
Finding the “Sweet Spot”: The Politics of Alignment in Cross-Sector Partnerships for Refugees
Authors: Henriksen S. E.
Published: August 2023

Cross-sector partnerships (CSPs) between nonprofits and businesses are increasingly implemented in response to humanitarian crises. These partnerships are motivated by ideals of alignment as stakeholders strive to find the “sweet spot” between humanitarian and business interests. However, this article shows that the ideals of alignment differ from the actual practices of alignment in the CSPs, and sweet spots are not merely found but constructed in and through changing relations of power. Based on an ethnographic case study of partnerships between a global humanitarian organization and five technology companies, the article deploys a theoretical lens from critical humanitarian studies to analyze how alignment in CSPs comes about in practice. This analysis demonstrates that in the construction of alignment, the companies’ interests become the priorities with which humanitarian organizations must align their and their beneficiaries’ needs. Consequently, while the discourse of sweet spots perpetuates an ideal of alignment where all partners benefit equally from the partnership, it legitimates power imbalances and asymmetrical alignment in practice.
Retrospective analysis of clinico-laboratory parameters, outcome and predictors of scrub typhus co- infection in covid-19 affected children
Authors: Sarkar Mihir , Roy Aniket , Bhakta Subhajit , Chowdhoury Satyabrata Roy , Mandal Rakesh Kumar
Published: August 2023

The objective of this study was to describe clinico-laboratory parameters, outcome and predictors of scrub typhus co- infection in COVID-19 affected children. Ours was a retrospective analysis done in a tertiary care pediatric COVID facility. COVID-19 positive children in the age group of 1 month to 12 years who were tested for scrub typhus co-infection between May to August 2020 were included in the study. In all positive cases, clinical, laboratory, treatment and outcome data were analyzed. Relevant data were compared between scrub typhus confirmed, and suspected but negative patients. All six patients with co-infection had fever for >5 days and four had features of cerebral involvement. These had lymphocytic pleocytosis in cerebrospinal fluid (CSF) analysis and two had eschar. Screening for scrub typhus in persistently febrile children residing in highly endemic areas is highly recommended.
Downward Accountability of NGOs in Bangladesh: Theoretical Issues and Empirical Investigation
Authors: Rahman Mizanur
Published: August 2023

This article analyses overall NGO accountability and accountability to beneficiaries in particular. It is based on the collection of qualitative data from four NGOs in Bangladesh. The participation of beneficiaries has been disaggregated into three phases for more analytical discussion: decision-making, implementation, and evaluation. The study results reveal that the participation of beneficiaries is much higher in the project/program implementation phase. The condition is alarming for the decision-making and evaluation phase, where participation is more rhetoric and sham rituals than the actual exercise. The study also identified some formal and informal mechanisms of participation.
Politics and Aesthetics: Jacques Rancière and Louis-Gabriel Gauny
Authors: Blaney Stuart
Published: August 2023

This paper argues that much of Jacques Rancière’s redefinition of emancipation owes a lot to one key character from his archival research on nineteenth-century worker-poets, Louis-Gabriel Gauny, the self-proclaimed plebeian philosopher. This is especially the case in regard to Rancière’s understanding of subjectivation forming a double of the self and a double of social reality as worlds within worlds. The paper puts forward that Gauny’s form of emancipation is valid today as an aesthetic revolution that reveals Rancière’s practices of equality to be an emancipatory way of life. In doing so, it will engage with Gauny’s connection with the contemporary precariat.
Does Institutional Quality Matter for Foreign Direct Investment and Human Development?
Authors: Thi Cam Ha Van , Doan Tinh , Holmes Mark J. , Tran Tuyen Quang
Published: August 2023

This study examines the relationship between foreign direct investment (FDI), institutional quality and human development) in host countries from 2002 to 2019, using the Human Development Index [HDI] as the measure of human development. This study utilized a panel dataset of 143 countries, including both developed and developing economies, over a 17-year period. Additionally, the study employed a GMM (generalized method of moments) estimator to address unobservable heterogeneity and simultaneity. This study reveals a significant positive relationship between FDI and human development, with a stronger effect observed in developing countries compared to in developed countries. Notably, the impact of FDI-HDI nexus is larger in countries with moderately high-quality institutions, irrespective of their income level. Furthermore, good governance plays a crucial role in enhancing human development, as developing economies with high governance quality experience a greater impact of FDI on HDI compared to other countries. The findings of this study suggest that attracting FDI can be beneficial for enhancing the HDI, especially in developing countries. Additionally, the study highlights governance as a moderating factor in the relationship between FDI and HDI. Improving governance quality can enhance the positive impact of FDI on human development in host countries, especially in developing countries.
Parental relationships, emotion regulation and orthorexia: A study on adolescent athletes
Authors: D’Urso Giulio , Maynard Andrea , Lionetti Francesca , Spinelli Maria , Fasolo Mirco
Published: August 2023

Background: This study seeks to further our understanding of the factors associated with adolescent athletes and disordered eating, by expanding current research into a less-explored eating disorder known as orthorexia. Aim: The aim of the study is to explore the impact of parents’ relationships and emotional regulation on the orthorexia nervosa (ON) tendencies of adolescent athletes. Methods: The participants were 303 adolescents, ranging from 15 to 17 years old, of which 139 participated in competitive sport, and 164 did not. Three self-report questionnaires were administered to assess orthorexia (ORTO-15), relationship with parents (Inventory of Parent and Peer Attachment) and emotion regulation (Emotion Regulation Questionnaire). Results: The results highlight that those who practice sports report higher levels of orthorexia, inadequate relationships with parents, as well as greater emotional regulation difficulties. Furthermore, inadequate parents’ relationship predicts orthorexia while expressive emotional regulation mediates this relationship. Conclusion: These findings highlight how ON tendencies in athletes are linked to poor management of emotions combined with inadequate relationships with parents in terms of communication and affection. Implications for practice and support for athletes are discussed.
Dietary intake and status of selenium in breast milk and serum of lactating mothers in Awka, South East Nigeria
Authors: Ezeama Nkiru N , Okunna Nene , Afonne Onyenmechi J
Published: August 2023

Background: Selenium is an essential micronutrient for human growth and development. Breast milk is usually the primary source of this nutrient for infants which is fundamental for their healthy brain development; its deficiency can lead to severe neurocognitive outcomes. The concentration of selenium in breast milk is dependent on the maternal diet. Aim: This study assessed associations between maternal diet and levels of selenium concentrations in breastmilk and serum of 124 lactating mothers. Methods: Breast milk and serum samples were collected from lactating mothers whose breast-fed infant was at least one month old. A validated food frequency questionnaire was used to collect information on dietary intake. Descriptive statistics were used to summarize the data while paired t-test was used to determine any statistically significant differences between sample means. Spearman's rank correlation analysis was used to determine associations between breast milk and serum selenium concentrations and study variables. Results: Average time postpartum was 2.9 months while mean concentrations of selenium in breast milk and serum were 6.57 ± 2.69 and 68.48 ± 26.86 µg/L, respectively. Levels of selenium in breast milk and serum were deficient for more than half of the lactating mothers. No statistically significant associations were found between breast milk selenium concentration and time postpartum as well as maternal diet except for eggs ( r = 0.23, p = 0.01). Conclusion: The evidence of deficient concentrations of breast milk selenium indicates a poor correlation with maternal diet and suggests the need for postpartum screening of breastfeeding mothers.
The Scalpel and the Ledger: Finance, Medicine and the Making of a Professional Life in Ireland, India and Britain, 1888–1921
Authors: Fitzpatrick Kieran , Cassidy Daniel
Published: August 2023

By the time of his death in September 1921, Peter Johnstone Freyer was an extremely wealthy man. After an education at Queen's College Galway, his medical career had been defined by colonial service in India, and the establishment of a successful surgery and consultancy on London's Harley Street. In public, these hallmarks of his career led to him being described by his contemporaries as amongst medicine's most prominent figures, and as a ‘great surgeon’ by newspapers the length of and breadth of the United Kingdom on the occasion of his death. However, his private papers show that his medical practice was only responsible for a small part of his material success; two-thirds of his wealth was derived from his skill, exercised in private, as an investor in financial markets. By establishing his history as an investor, and comparing it to his public profile in medicine, this article traces the social and cultural histories of professional identity in late-Victorian and Edwardian London. Over the course of its arc, it demonstrates how medicine's public significance in this period was part of a broader, middle-class, professional culture concerned with the accrual of ‘virtual’ wealth, the construction of advantageous social networks, and the tapping of capital in multiple forms. In sum, Freyer's career reflects the symbolic meaning of publicly wielding a scalpel, whilst privately managing a portfolio of financial ledgers.
Investigating the role of synthesized reduced graphene oxide and graphite micro-fillers on mechanical and fretting wear performance of glass fiber epoxy-based composite
Authors: Singh Sandeep Kumar , Nayak Biswajeet , Singh Thingujam Jackson , Halder Sudipta
Published: August 2023

In the current study, graphite was exfoliated using a Hummer’s technique to produce graphene oxide (GO), which was then reduced with hydrazine hydrate (a reducing agent) to produce reduced graphene oxide (rGO) with high purity. The XRD, FT-IR, SEM, and TGA analysis confirmed the synthesis of rGO by stating its crystal phase, chemical functional group, morphology, and thermal stability. The objective of this study is twofold: firstly, to synthesize the reduced graphene oxide (rGO) cost-effectively, and secondly, to explore its potential as an additional filler in Glass Fiber Reinforced Polymer (GFRP) composites. Aiming to enhance their overall performance. The GFRP laminate composite was fabricated through the hand layup technique by varying the concentration of Gr (i.e., 0.5 wt% & 1 wt%) and rGO (i.e., 0.5 wt% & 1 wt%). The morphological study of the fracture surface revealed a proper dispersion of filler obtained at 0.5 wt% and by increasing the concentration to 1 wt% it reveals a clustering of fillers and formation of micro-voids. The result revealed that maximum improvement has been observed in the GFRP composite having 0.5 wt% rGO composite than neat GFRP composite. Incorporation of rGO micro-filler in GFRP laminate composite significantly improved the tensile strength, flexural strength, and in their modulus by 59.56%, 18.21%, 24.45%, and 22.75% respectively compared to neat GFRP laminate composite. In the case of 0.5 wt% graphite filler demonstrates an enhancement in tensile strength, flexural strength, and their modulus by 37.98%, ∼8%, 6.64%, and ∼5% respectively. In fretting wear test reveals that 1 wt% of graphite filler has better wear resistance than all other composites. The worn morphology revealed adhesive and abrasive wear as the predominant wear mechanism. The incorporation of rGO filler in GFRP makes it a promising material for industrial applications that demand high strength and superior wear resistance.
Does it decay? Obtaining decaying correlation parameter values from previously analysed cluster randomised trials
Authors: Kasza Jessica , Bowden Rhys , Ouyang Yongdong , Taljaard Monica , Forbes Andrew B
Published: August 2023

A frequently applied assumption in the analysis of data from cluster randomised trials is that the outcomes from all participants within a cluster are equally correlated. That is, the intracluster correlation, which describes the degree of dependence between outcomes from participants in the same cluster, is the same for each pair of participants in a cluster. However, recent work has discussed the importance of allowing for this correlation to decay as the time between the measurement of participants in a cluster increases. Incorrect omission of such a decay can lead to under-powered studies, and confidence intervals for estimated treatment effects can be too narrow or too wide, depending on the characteristics of the design. When planning studies, researchers often rely on previously reported analyses of trials to inform their choice of intracluster correlation. However, most reported analyses of clustered data do not incorporate a correlation decay. Thus, often all that is available are estimates of intracluster correlations obtained under the potentially incorrect assumption of no decay. In this article, we show that it is possible to use intracluster correlation values obtained from models that incorrectly omit a decay to inform plausible choices of decaying correlations. Our focus is on intracluster correlation estimates for continuous outcomes obtained by fitting linear mixed models with exchangeable or block-exchangeable correlation structures. We describe how plausible values for decaying correlations may be obtained given these estimated intracluster correlations. An online app is presented that allows users to obtain plausible values of the decay, which can be used at the trial planning stage to assess the sensitivity of sample size and power calculations to decaying correlation structures.
Analysing the Impact of Omni-channel Customer Delight on Repurchase Intention
Authors: Gupta Rajeev , Kumar Vikas , Kaushik Arun Kumar , Gupta Devashish Das
Published: August 2023

Merely satisfying the customers is not enough; delighting them by offering unexpected, innovative and surprising services has become crucial. For this, firms invest in several channels and attract delighted customers. The current research examines the impact of Omni-channel customer delight on customers’ repurchase intention. The proposed conceptual model develops several hypotheses relating to customer delight in the Omni-channel context by reviewing rich literature on customer delight. Data were collected from 496 respondents using convenience sampling, representing 24 states of India. Using Smart PLS software, collected data were examined through structural equation modelling. Surprise and joy are crucial to offline customer delight, while satisfaction, usefulness and entertainment play significant roles in online customer delight. Also, Omni-channel customer delight significantly influences repurchase intentions; therefore, paying attention to all antecedents of customer delight is essential. The research provides a basic understanding of customer delight in Omni-channel contexts and offers directions to formulate various strategies to delight customers beyond satisfaction. The article adds value to existing knowledge relating to Omni-channel retailing. Omni-channel customer delight is undoubtedly an emerging research domain in the current Omni-channel retailing.
Effective Schoolwide Practices in Support of Students With Extensive Support Needs in an Inclusive Elementary School
Authors: Maurer Karolyn J. , Fischbacher Lauren , Fensterstock Natalie , Osipova Anna V.
Published: August 2023

While federal law requires public schools to provide students with disabilities a free and appropriate public education in the least restrictive environment, students with extensive support needs are excluded from general education at alarming rates, raising concerns about equity of access to education. Purposeful school systems in which students’ needs can be met are critical to establish for schools working towards inclusion. The current study used qualitative case study methods to identify schoolwide practices contributing to the successful inclusion of students with extensive support needs in an urban elementary school. Eight interviews with school stakeholders – teachers, parents, a paraprofessional, and an administrator – were conducted. Results revealed formal collaboration structures were embedded within the school’s program, offering teachers and staff consistent opportunities to work together. Four school systems were also found to be critical for the school’s inclusion model, including the Multi-Tiered Systems of Support framework, instructional coaching practices, hiring, and scheduling. The study adds to the literature by detailing inclusive practices, intended to provide administrators with an example of how common systems are operationalized within an effective inclusion model. Future research to support the implementation of systems and practices is discussed.
Dysgraphia and Dyslexia Indicators: Analyzing Children’s Writing
Authors: Baggett Mercedes , Diamond Lindsay L. , Olszewski Abbie
Published: August 2023

Even though the most prevalent category of disability served in the U.S. school system is specific learning disabilities (SLD), practitioners are often unfamiliar with the indicators associated with a specific LD such as dysgraphia and dyslexia. Misconceptions or an absence of understanding of the behavioral indicators related to dysgraphia and dyslexia puts children at risk for poor academic or social success due to a lack of intervention or late or missed diagnosis. Practitioners can utilize the Dysgraphia and Dyslexia Behavioral Indicator Checklist to identify these indicators in students’ writing samples, design appropriate instructional intervention(s), and refer them for proper assessment.
Growth and Utility of Language and Early Literacy Measures for Young Children
Authors: McConnell Scott R. , Wackerle-Hollman Alisha K. , Albano Anthony D. , Lease Erin M. , Elmquist Marianne , Will Kelsey K.
Published: August 2023

Ongoing expansion of early education services in the United States is often rooted in these programs’ contribution to development that promotes later academic and behavioral competence. Multi-tiered systems of support (MTSS, sometimes referred to as Response to Intervention) represent one increasingly common resource to promote desired outcomes for all children. MTSS requires seasonal screening of all students and progress monitoring of those selected for more intensive intervention. This study explores development and evaluation of measures for these uses, designed specifically to assess the language and early literacy development of 3-year-old children. Results from assessment of 449 children describe measure reliability, growth across three seasonal screenings, development of criterion-referenced benchmarks, and variations in growth for children at different levels of initial performance. Results are discussed in terms of normative versus criterion-referenced standards for building MTSS assessment systems as well as future directions for research, policy, and practice.
Systematic investigations on frequency mixing response of ultrasonic shear horizontal and Rayleigh Lamb waves
Authors: Jiang Chang , Li Weibin , Deng Mingxi
Published: August 2023

The study of self- and cross-interactions of shear horizontal (SH) waves has garnered significant attention in the field of nonlinear ultrasonic practice. This interest stems from the potential high sensitivity of SH waves to microdamage and their low out-of-plane attenuation characteristics. However, due to the dispersive nature and intricate mechanisms governing guided wave propagations and interactions, the nonlinear responses of SH waves, particularly the third-order harmonic generation and wave mixing with Rayleigh Lamb (RL) waves, remain largely unexplored. This study presents a comprehensive investigation into the ultrasonic harmonic wave generation of SH guided waves. The research approach combines theoretical considerations and finite element modeling to investigate and discuss guided wave mixing involving SH and RL waves. Six cases of phase-matched wave mode pairs are developed based on deduced synchronism and symmetry conditions. A nonlinear material constitutive model, encompassing both the third- and fourth-order elastic constants, is incorporated into the simulation. The results of the numerical analysis reveal the existence of newly generated higher and combined harmonic waves in an intuitive manner. Specifically, the interactions between ultrasonic SH and RL guided waves are observed to generate second- and third-order combined harmonic waves at the mixing frequencies under internal resonant conditions. The nonlinear waves have a cumulative effect during the mixing period, with their amplitude remaining constant after passing through the mixing zone. This study provides the first observation of mode conversion and third-order combined harmonic generation of SH waves. The insights gained from the numerical perspective offer understandings of the frequency mixing response of SH waves.