bluuebunny/crossref_metadata_2025 huggingface dataset:
A Sensitivity Test on the Modifiable Areal Unit Problem in the Spatial Aggregation of Fossil Data
Authors: Ye Shan
Published: September 2024

In paleobiology and macroevolution research, the spatial aggregation of fossil data can be influenced by the modifiable areal unit problem (MAUP), wherein the selection of different grid-cell sizes for data aggregation can lead to variations in statistical results. This study presents a case analysis focused on the spatial extent of marine bivalves and brachiopods over time across three Areas of Interest (AOIs) to evaluate the potential impact of the MAUP in grid-based fossil data processing. By employing rectangular grid matrices with cell sizes of 50, 100, 200, and 400 km, this research assesses the MAUP-related sensitivity of two commonly used grid-based proxies for species’ spatial distribution. The results reveal that the proxy based on the number of occupied grid cells (OGCs) is particularly sensitive to changes in cell size, whereas the proxy based on minimum-spanning-tree distance (MST distance) demonstrates greater robustness across varying grid scales. This study underscores that when constructing proxies for species’ spatial distribution ranges using grid matrices, the OGC method is more susceptible to MAUP effects than the MST distance method, warranting increased caution in studies employing the OGC approach.
Native Hawaiian and Pacific Islanders’ Identity and Housing Status: The Impact on Historical Trauma and Perceived Stress
Authors: Palafu Tessa , Carreira Ching Danielle L. , Acosta Veronica M. , Okamoto Scott K. , Okamura Kelsie H.
Published: September 2024

Native Hawaiian and Pacific Islanders (NHPIs) are overrepresented in Hawai‘i’s houseless population. Indigenous populations, such as NHPIs, may encounter experiences of historical trauma that impact their well-being. This original research project examines how NHPI identity and houselessness compound to affect the perceived stress and historical trauma of transition-aged youth. Fifty-one participants aged 18 to 24 (M = 21.37, SD = 1.93) completed a survey that included the historical traumatic events scale, historical loss scale, perceived stress scale, and a demographic questionnaire. Over half (n = 26, 51.0%) of the participants identified as NHPI. A two-way ANOVA indicated a non-significant effect of NHPI identity and housing status on perceived stress. However, housed participants scored significantly higher than participants experiencing houselessness on the historical traumatic events scale (p = 0.006). Our findings elucidate the role of knowledge in the experience of historical trauma. Further results, limitations, and future directions are offered.
Nonlinear Influence of the Built Environment on the Attraction of the Third Activity: A Comparative Analysis of Inflow from Home and Work
Authors: Luo Lin , Yang Xiping , Chen Xueye , Liu Jiayu , An Rui , Li Jiyuan
Published: September 2024

Gaining an understanding of the intricate mechanisms between human activity and the built environment can help in promoting sustainable urban development. However, most scholars have focused on residents’ life and work behavior and have ignored the third activity (e.g., shopping, eating, and entertainment). In this study, a random forest algorithm and SHapley Additive exPlanation model were utilized to explore the nonlinear influence of the built environment on the attraction of the third activity (other than home and work). A comparative analysis of the inflow of the third activity from home and work was also carried out. The results show that the contributions of all built environment variables to the attraction of the third activity differ between home–other flow (HO) and work–other flow (WO) at the global scale, but their local effects are significantly similar. Furthermore, the nonlinear influence of the built environment on the attractions of the third activity can vary from one factor to another. A significant spatial heterogeneity can be observed on the built environment variables’ local effects on the attractions of the third activity. These findings can provide urban planners with insights that will help in the planning and optimization of communities for pursuing the third activity.
Phenotypic, Metabolic, and Functional Characterization of Experimental Models of Foamy Macrophages: Toward Therapeutic Research in Atherosclerosis
Authors: Henni Mansour Amina Sarah , Ragues Mathilde , Brevier Julien , Borowczyk Coraline , Grevelinger Janaïna , Laroche-Traineau Jeanny , Garaude Johan , Marais Sébastien , Jacobin-Valat Marie-Josée , Gerbaud Edouard , Clofent-Sanchez Gisèle , Ottones Florence
Published: September 2024

Different types of macrophages (Mφ) are involved in atherogenesis, including inflammatory Mφ and foamy Mφ (FM). Our previous study demonstrated that two-photon excited fluorescence (TPEF) imaging of NADH and FAD autofluorescence (AF) could distinguish experimental models that mimic the different atherosclerotic Mφ types. The present study assessed whether optical differences correlated with phenotypic and functional differences, potentially guiding diagnostic and therapeutic strategies. Phenotypic differences were investigated using three-dimensional principal component analysis and multi-color flow cytometry. Functional analyses focused on cytokine production, metabolic profiles, and cellular oxidative stress, in LDL dose-dependent assays, to understand the origin of AF in the FAD spectrum and assess FM ability to transition toward an immunoregulatory phenotype and function. Phenotypic studies revealed that FM models generated with acetylated LDL (Mac) were closer to immunoregulatory Mφ, while those generated with oxidized LDL (Mox) more closely resembled inflammatory Mφ. The metabolic analysis confirmed that inflammatory Mφ primarily used glycolysis, while immunoregulatory Mφ mainly depended on mitochondrial respiration. FM models employed both pathways; however, FM models generated with high doses of modified LDL showed reduced mitochondrial respiration, particularly Mox FM. Thus, the high AF in the FAD spectrum in Mox was not linked to increased mitochondrial respiration, but correlated with the dose of oxidized LDL, leading to increased production of reactive oxygen species (ROS) and lysosomal ceroid accumulation. High FAD-like AF, ROS, and ceroid accumulation were reduced by incubation with α-tocopherol. The cytokine profiles supported the phenotypic analysis, indicating that Mox FM exhibited greater inflammatory activity than Mac FM, although both could be redirected toward immunoregulatory functions, albeit to different degrees. In conclusion, in the context of immunoregulatory therapies for atherosclerosis, it is crucial to consider FM, given their prevalence in plaques and our results, as potential targets, regardless of their inflammatory status, alongside non-foamy inflammatory Mφ.
Modular Hemipelvic Prosthesis Preserves Normal Biomechanics and Showed Good Compatibility: A Finite Element Analysis
Authors: Luo Yuanrui , Sheng Hongtao , Zhou Yong , Min Li , Tu Chongqi , Luo Yi
Published: September 2024

This study aimed to evaluate the biomechanical compatibility of a modular hemipelvic prosthesis by comparing stress distributions between an implanted pelvis and a healthy pelvis. Finite element analysis was used to simulate bilateral standing loads on both models, analyzing critical regions such as the sacroiliac joints, iliac crest, acetabulum, and prosthesis connection points. Six models with varied displacements of the hip joint rotational center were also introduced to assess the impact of deviations on stress distribution. The implanted pelvis had a stress distribution closely matching that of the intact pelvis, indicating that the prosthesis design maintained the biomechanical integrity of the pelvis. Stress patterns in displacement models with deviations of less than 10 mm were similar to the standard model, with only minor changes in stress magnitude. However, backward, upward, and inward deviations resulted in stress concentrations, particularly in the prosthesis connection points, increasing the likelihood of mechanical failure. The modular hemipelvic prosthesis demonstrated good biomechanical compatibility with minimal impact on pelvic stress distribution, even with moderate deviations in the hip joint’s rotational center; outward, forward, and downward displacements are preferable to minimize stress concentration and prevent implant failure in cases where minor deviations in the rotational center are unavoidable during surgery.
Optimizing High-Performance Predictive Modeling of the Medium-Speed WEDM Processing of Inconel 718
Authors: Salem Osama , Hewidy Mahmoud , Jung Dong Won , Lee Choon Man
Published: September 2024

The purpose of this research was to create a predictive model for a medium-speed wire electrical discharge machine (WEDM) utilizing an artificial neural network (ANN). Medium-speed WEDM experiments were developed based on the I-optimal mixture design for machining, the Inconel 718 superalloy. During the experiment, the input parameters were the spark ontime, spark offtime, wire feed, and current, with the material removal rate (MRR) and surface roughness (Ra) selected as performance indicators. The ANN model was trained on experimental data and built using a feed-forward backpropagation neural network with a (4-8-2) structure and the Bayesian regularization (BR) learning approach. The model correctly predicted the relationship between the medium-speed WEDM’s primary process parameters and machining performance. An integrated ANN model and the Non-Dominated Sorting Genetic Algorithm-II (NSGA-II) were used to determine the ideal parameters for the MRR and Ra, resulting in a set of Pareto-optimal solutions. The confirmation experiment revealed that the mean prediction error between the experimental and ideal solutions had a maximum error percentage of 1% for the MRR and 2% for the Ra, which are within acceptable ranges. This showed that the best process–parameter combinations were better for the MRR and Ra.
Visceral Fat Thickness, Serum Adiponectin, and Metabolic Syndrome in Patients with Colorectal Adenomas
Authors: Damjanov Dimitrije , Ičin Tijana , Savić Željka , Janjić Nebojša , Nikolić Stanislava , Bošnjak Olgica Latinović , Krnetić Žarko , Vračarić Vladimir , Dejanović Božidar , Kovačević Nadica
Published: September 2024

Background/Objectives: Most cases of colorectal cancer (CRC) arise from adenomatous polyps. Identifying risk factors for colorectal adenoma (CRA) is critical for CRC prevention. Emerging evidence suggests a link between metabolic syndrome (MetS) and an elevated risk of CRA and CRC, potentially mediated by visceral obesity and adiponectin (APN). We aimed to evaluate the association between different markers of visceral obesity, serum APN, MetS, and the presence of CRA. Methods: A cross-sectional study was conducted at the University Clinical Center of Vojvodina, involving 120 patients, aged 40–75 years, who underwent colonoscopy between January 2022 and January 2023. Sixty patients with CRA were compared to 60 controls with normal colonoscopy findings. Visceral fat thickness (VFT) was measured using ultrasound (US), and bioelectrical impedance analysis (BIA) was used to assess visceral fat area (VFA). Serum APN levels, anthropometric measures, and MetS components were also evaluated. Results: Patients with CRA had significantly higher VFT measured by US (p < 0.05), but no significant differences were found in VFA measured by BIA, waist circumference (WC), or waist-to-hip ratio (WHR). MetS was significantly more prevalent in the CRA group (55% vs. 31.6%, p < 0.05), and logistic regression confirmed MetS as a significant predictor of CRA presence (OR = 2.6). Serum APN levels were inversely correlated with visceral fat measurements and MetS (p < 0.01), but no significant difference in APN levels was observed between patients with and without CRA. Conclusions: This study highlights the importance of VFT measured by US and the presence of MetS as significant factors associated with CRA.
The Effects of Public Spaces on People’s Experiences and Satisfaction in Taif City: A Cross-Sectional Study
Authors: Halawani Raghad
Published: September 2024

Public places play a central role in shaping positive and negative human experiences. They have a profound impact on people’s lives, affecting their sense of place, well-being, and overall quality of life. While public spaces have such an impact, little is known about their effects on the overall experiences of people in Saudi cities. Particularly, in Saudi Arabia, the form of public spaces has rapidly evolved and changed in recent years. Therefore, this study examined the impact of urban public spaces on people’s experiences, aiming to assess satisfaction levels within the broader context of urban life in Saudi Arabia. Specifically, it investigated the correlation between the public spaces and individuals’ perceptions and feelings toward the environment of Taif city. Taif is one of the key cities in Saudi Arabia targeted for significant improvements in quality of life as part of the 2030 vision. Therefore, it is important to study the effects on the residents there. The method used in the study involved quantitative data collected through a survey of 384 participants from Taif, which included questions measuring multiple aspects of the quality of urban public life, including the safety, walkability, social interaction, and functionality of public spaces. The results indicate that people in Taif would face a jeopardised level of satisfaction, as not all elements of the public spaces meet the desired standards. Therefore, their experiences would be impacted negatively if the noted concerns are not addressed. By identifying key urban design elements that impact people’s experiences and overall well-being, this research provides a foundation for planners and policymakers to work towards achieving the Saudi vision of creating more liveable and enduring urban environments in Saudi Arabian cities.
The Impacts of Urban Population Growth and Shrinkage on the Urban Land Use Efficiency: A Case Study of the Northeastern Region of China
Authors: Kang Haoyang , Fu Meichen , Kang Haoran , Li Lijiao , Dong Xu , Li Sijia
Published: September 2024

In the context of rapid urbanization, urban population differentiation has become increasingly pronounced. Regional development strategies based on growth scenarios often lead to continuous expansion, regardless of urban population status. Such “one-size-fits-all” models exacerbate resource waste and negatively impact urban land use efficiency (ULUE). This study aims to explore the mechanisms by which urban population growth and shrinkage (UPGS) affect ULUE, with the goal of enhancing ULUE and promoting sustainable urban development. We analyzed 34 prefecture-level cities in China’s three northeastern provinces. First, we identified UPGS using population data. We then employed a three-stage SBM-DEA model to measure ULUE from 2000 to 2020. Spatial analysis methods were used to examine the spatiotemporal characteristics and correlations between UPGS and ULUE. Additionally, mediating effect models and spatial Durbin models were utilized to empirically test the impact processes, mechanisms, and spatial heterogeneity. Our findings reveal that: (1) Over the past 20 years, urban population shrinkage in northeastern China has intensified, and significant regional disparities in urban development are evident. (2) Population growth positively influences ULUE, while population shrinkage inhibits its improvement. (3) Economic development, technological innovation, and industrial structure upgrading are key factors in enhancing ULUE in this region, while the impact of public services on ULUE varies significantly at different stages of urban development. (4) Economic development, technological innovation, and industrial structure upgrading exhibit spatial spillover effects, whereas public services are constrained by regional limitations, resulting in minimal spatial spillover effects. To foster coordinated regional development, this study proposes policy recommendations, including strengthening support for resource-dependent cities, optimizing the allocation of public resources, and promoting technological innovation and industrial diversification.
The Environmental Legal Framework of Mexican Caribbean Dunes: A Retrospective Case Study of Vegetation and Coastal Dune Loss in the Sian Ka’an Biosphere Reserve
Authors: Gayosso-Soto Eloy , Cohuo Sergio , Sánchez-Sánchez Joan Alberto , Macario-González Laura , Villegas-Sánchez Carmen Amelia , Medina-Quej Alejandro , Tello-Chan Jorge Manuel , Cutz-Pool Leopoldo Querubín , Castro-Pérez José Manuel
Published: September 2024

The Mexican Caribbean coastal dune is protected by national and international environmental legislation. However, through permits, concessions and authorizations for changes in land use, the coastal dune has been fragmented or suppressed, mainly for touristic activities, causing a decline in protective and ecological ecosystem services. In this study, we evaluated the strength and weakness of Mexican legislation to protect the Caribbean coastal dune ecosystem and estimated the historical and current effects on coastal dune vegetation and dune geomorphology, associated with legal allowances of land use change in the Sian Ka’an Biosphere Reserve (SKBR). Legislation at the federal, state and local level were critically reviewed, and with remote sensing techniques and the Remotely Piloted Aircraft System (RPAS), we conducted a case study in the SKBR to estimate coastal dune vegetation alteration trends during the period 2011–2020 and modifications on the dune geomorphology associated with land use change allowances. At the federal (four laws), state (eight laws) and local (nine Local and Territorial Planning Programs (POEL and POET) levels, we found a lack of consensus and alignment between regulations, starting with a lack of definition of ecosystems subject to protection. For coastal dunes, none of them consider topography, ecological function and a way to identify it in the field, making the surveillance highly complex and favoring land use changes, the removal of vegetation and dune geomorphology alteration. Remote sensing techniques showed that areas with land use authorizations exhibit negative vegetation cover trends (Mann–Kendall <−0.4), indicating a decline in vegetation cover density that is mostly anthropogenically induced. The RPAS analysis demonstrated drastic alterations to complete elimination of the coastal dune geomorphology in areas with land use change. In the Mexican Caribbean, the loss of coastal dune and associated ecosystem by the lack of congruent legislation threatens the environmental stability of the coastal areas.
Shrinkage Does Not Follow Population Decline on a Regional Scale: Planning and Reality of Residential Area in Japan
Authors: Seta Fumihiko
Published: September 2024

This study first examines changes in the amount of residential area on a regional scale, which is said to shrink following population decline, using Japan as an example, where population decline is already underway in most of the country. Second, it examines how the regional governments have set future targets for residential areas and whether these targets are consistent with the current trend. Third, it examines how prefectures, Japan’s regional governments, are responding to this situation through regional land use planning. The methodologies of the paper are a combination of collecting and sorting out the related data, reviewing and extracting information from planning documents, and conducting interviews with persons in charge. In conclusion, residential areas have continued to increase on a regional scale, even as the population has declined. Shrinkage does not follow population decline on a regional scale. It was also found that the amount of residential area changed more closely with the change in households than with the population. National and regional land use plans generally set targets for more shrinkage than the actual trend. The underestimation of the amount of residential area was due to the rapid decline in the number of persons per household. Cases of the three prefectures showed that specific control is left to the individual acts, while the measures are indicated in the wording by the prefectural land use plans.
Reproductive Performance of the Alpine Plant Species Ranunculus kuepferi in a Climatic Elevation Gradient: Apomictic Tetraploids Do Not Show a General Fitness Advantage over Sexual Diploids
Authors: Ladinig Ursula , Hörandl Elvira , Klatt Simone , Wagner Johanna
Published: September 2024

Previous studies on the mountain plant Ranunculus kuepferi concluded that apomictic self-compatible tetraploids have experienced a niche shift toward a colder climate during the Holocene, which suggests a fitness advantage over the sexual, self-sterile diploid parents under cold and stressful high-mountain conditions. However, there is still a lack of information on whether reproductive development would be advantageous for tetraploids. Here, we report on microsporogenesis, megagametogenesis, the dynamics of flower and seed development, and the consequences for reproductive success in a common garden experiment along a 1000 m climatic elevation gradient and in natural populations. Flower buds were initiated in the year preceding anthesis and passed winter in a pre-meiotic stage. Flower morphology differed in the known cytotype-specific way in that tetraploid flowers produced about twice as many carpels and fewer petals, stamens, and pollen grains than diploid flowers. Tetraploids developed precociously aposporous embryo sacs and showed a high rate of developmental disturbances. Sexual seed formation prevailed in diploids and pseudogamous apomixis in tetraploids. Along the elevation gradient, stigma pollen load, pollen performance, and seed output decreased. Combinations of reproductive traits, namely, bypass of meiosis irregularities and uniparental reproduction, might have promoted the vast expansion of apomictic R. kuepferi lines across the European Alps.
Effects of Drying Methods on the Phytochemical Contents, Antioxidant Properties, and Anti-Diabetic Activity of Nasturtium officinale R.Br. (Betong Watercress) from Southern Thailand
Authors: Kijkuokool Praporn , Stepanov Irina , Ounjaijean Sakaewan , Koonyosying Pimpisid , Rerkasem Kittipan , Chuljerm Hataichanok , Parklak Wason , Kulprachakarn Kanokwan
Published: September 2024

Nasturtium officinale R.Br. (Betong watercress) contains high levels of secondary metabolites that offer health benefits. However, fresh-cut watercress has a short shelf life. This study aimed to assess the effect of drying methods on the phytochemical contents, antioxidant activity, and anti-diabetic activity of Betong watercress. The watercress was dried using three methods: roasting (R, 50 °C, 40 min); roasting and drying (RD, 40 min roasting at 50 °C and 1 h drying at 80 °C); and blanching, roasting, and drying (BRD, 30 s blanching at 80 °C, 20 min roasting at 50 °C, and 1 h drying at 80 °C). Aqueous extracts from each drying method were analyzed for total phenolic content, total flavonoid content, total glucosinolate content, antioxidant activities (FRAP, DPPH, and ABTS assays), and α-amylase enzyme inhibition. From the results, the R method provided the highest level of total phenolic, total flavonoid, and total glucosionolate content compared to the RD and BRD methods. Similarly, antioxidant activities and α-amylase enzyme inhibition were highest in the R method, followed by the RD and BRD methods. Our results demonstrate that roasting of Betong watercress without the addition of blanching or drying effectively preserves the phytochemical contents, antioxidant activities, and anti-diabetic activity.
The Role of Paraclinical Investigations in Detecting Inflammation in Children and Adolescents with Obesity and Metabolic Syndrome
Authors: Podeanu Mihaela-Andreea , Vintilescu Ștefănița Bianca , Ionele Claudiu Marinel , Sandu Raluca Elena , Niculescu Carmen Elena , Florescu Mirela-Marinela , Stepan Mioara Desdemona
Published: September 2024

Obesity is linked to the increasing prevalence of metabolic syndrome (MetS), even among the pediatric population. Some inflammatory and cardioembolic indexes derived from routine laboratory tests have captivated the attention of the medical community. Objectives: The aim of our study was to evaluate whether these markers are effective in distinguishing varying degrees of obesity and MetS in children and adolescents. Methods: We conducted a retrospective study. A total of 71 children and adolescents, aged between 6 and 16, were included in the study. Among them, 5 were overweight, 35 had obesity, and 31 had severe obesity. According to the NCEP ATP III criteria, 32 individuals had Metabolic Syndrome (MetS), while 39 did not have MetS. Results: The MetS positive group had higher values of TG/HDL-C (p < 0.001), TC/HDL-C (p < 0.001), MHR (p = 0.015), LHR (p = 0.001), NHR (p = 0.001), atherogenic index of plasma (p < 0.001), and PHR (p < 0.001). ESR, NLR, PLR, and SII did not progressively increase with the number of MetS criteria. The ROC curve analysis demonstrated that markers such as TG/HDL-C, the atherogenic index of plasma, TC/HDL-C, LHR, NHR, and PHR were effective in identifying MetS in children and adolescents with obesity. Conclusions: In conclusion, we determined that some novel inflammatory and cardioembolic indexes are useful in assessing MetS and obesity in children and adolescents.
Practical Use of Ultrasound in Modern Rheumatology—From A to Z
Authors: Sapundzhieva Tanya , Sapundzhiev Lyubomir , Batalov Anastas
Published: September 2024

During the past 20 years, the use of ultrasound (US) in rheumatology has increased tremendously, and has become a valuable tool in rheumatologists’ hands, not only for assessment of musculoskeletal structures like joints and peri-articular tissues, but also for evaluation of nerves, vessels, lungs, and skin, as well as for increasing the accuracy in a number of US-guided aspirations and injections. The US is currently used as the imaging method of choice for establishing an early diagnosis, assessing disease activity, monitoring treatment efficacy, and assessing the remission state of inflammatory joint diseases. It is also used as a complementary tool for the assessment of patients with degenerative joint diseases like osteoarthritis, and in the detection of crystal deposits for establishing the diagnosis of metabolic arthropathies (gout, calcium pyrophosphate deposition disease). The US has an added value in the diagnostic process of polymyalgia rheumatica and giant-cell arteritis, and is currently included in the classification criteria. A novel use of US in the assessment of the skin and lung involvement in connective tissue diseases has the potential to replace more expensive and risky imaging modalities. This narrative review will take a close look at the most recent evidence-based data regarding the use of US in the big spectrum of rheumatic diseases.
Morphophysiological and Histopathological Effects of Ammonium Sulfate Fertilizer on Aporrectodea trapezoides (Dugès, 1828) Earthworm
Authors: Aouaichia Khaoula , Grara Nedjoud , Bazri Kamel Eddine , Barbieri Edison , Mamine Nedjma , Hemmami Hadia , Capaldo Anna , Rosati Luigi , Bellucci Stefano
Published: September 2024

The present study used the adult earthworm Aporrectodea trapezoides as a bioindicator species to look into the possible dangers of ammonium sulfate (AS) fertilizer. Two complementary toxicity tests were conducted to determine the LC50values, growth rate inhibition, morphological alterations, and histopathological texture of worms. The lethality test included four increasing concentrations of AS fertilizer (ranging from 2500 to 7500 mg/kg of dry soil weight (d.w.)), while sub-lethal concentrations were based on 10%, 30%, 40%, and 50% of the 14-day median lethal concentration (LC50), with a control group included for both tests. The LC(50) values for AS fertilizer were significantly higher at 7 days (4831.13 mg/kg d.w.) than at 14 days (2698.67 mg/kg d.w.) of exposure. Notably, earthworms exhibited significant growth rate inhibition under exposure to various concentrations and time durations (14/28 exposure days). Morphological alterations such as clitellar swelling, bloody lesions, whole body coiling and constriction, body strangulation, and fragmentation were accentuated steadily, with higher concentrations. Histopathological manifestations included severe injuries to the circular and longitudinal muscular layers, vacuolation, muscle layer atrophy, degradation of the chloragogenous tissue in the intestine, collapsed digestive epithelium of the pharynx with weak reserve inclusion, and fibrosis of blood vessels. These effects were primarily influenced by increasing concentrations of fertilizer and time exposure. The study highlights the strong relationship between concentration and exposure time responses and underscores the potential of A. trapezoides earthworms as valuable biological control agents against acidic ammonium sulfate fertilizer. Importantly, this research contributes to the use of such biomarkers in evaluating soil toxicity and the biological control of environmental risk assessment associated with chemical fertilizers.
Application of Closed Incision Negative Pressure Wound Therapy in Ventral Hernia Repair Surgery Using a Polypropylene Mesh: A Randomized Clinical Trial
Authors: Jelinek Petr , Hrubovcak Jan , Hajovsky Radovan , Velicka Jan , Pies Martin
Published: September 2024

Background and Objectives: Surgical site infections (SSIs) are a significant complication following ventral hernia repair, potentially leading to prolonged hospital stays and increased morbidity. This study aimed to evaluate whether closed incision negative pressure wound therapy (ciNPWT) reduces the incidence of SSI after ventral hernia repair with polypropylene mesh compared to standard wound care. Materials and Methods: A randomized study was conducted with 100 patients undergoing ventral hernia repair using a polypropylene mesh. Participants were divided into two groups: a control group (n=50), which received standard sterile gauze dressing with an iodine-based disinfectant, and an intervention group (n=50), treated with the ciNPWT system (Vivano® by HARTMANN) for 5 days postoperatively. The primary outcome was the incidence of SSI within one year after surgery. Secondary outcomes included the influence of factors such as age, sex, smoking status, and hernia size on SSI occurrence. The study was approved by the Ethics Committee at the University Hospital Ostrava, adhering to the ethical standards of the Helsinki Declaration. Results: The incidence of SSI was lower in the ciNPWT group compared to the standard care group (4% vs. 12%), though this difference did not reach statistical significance. No significant effect of sex or smoking status on SSI was observed. The control group had a shorter mean length of hospital stay. Larger hernias in the non-ciNPWT group were more prone to SSIs, as expected. Conclusions: Although limited by a small sample size, the findings suggest that ciNPWT may be associated with a reduced rate of SSI following ventral hernia repair. Further studies with larger populations are needed to confirm these results.
Granulomatosis with Polyangiitis Discovered Because of Repeated Upper Eyelid Swelling
Authors: Nakagawa Suguru , Totsuka Kiyohito , Kagami Shinichiro , Nomoto Yohei
Published: September 2024

Background and objectives: The initial symptom that triggers granulomatosis with polyangiitis (GPA) diagnosis is rarely ocular. We describe a case with a single ocular lesion identified as probable GPA due to proteinase 3 (PR3)-antineutrophil cytoplasmic antibody (ANCA)-positivity according to the diagnostic criteria of the Ministry of Health in Japan; the lesion repeatedly worsened. Materials and methods: A 25-year-old female visited the Department of Ophthalmology, Asahi General Hospital, with upper eyelid swelling and conjunctival and episcleral hyperemia of the left eye. Both hordeolum and eyelid cellulitis were suspected, as the condition was resistant to treatment with antibiotic eye drops. Episcleritis was suspected due to localized hyperemia in the upper part of the eye. Upon treatment with antibacterial agents and steroid eye drops, the swelling and the hyperemia repeatedly worsened every week. Results: Blood samples were positive for PR3-ANCA, and GPA with an isolated ocular lesion was considered. After oral steroid treatment, the patient had no recurrence for 4 years. There was no systemic involvement in the upper respiratory tract, lungs, or kidneys. Conclusions: Diagnosing GPA with ocular symptoms as initial manifestations is challenging. GPA should be considered in treatment-resistant eyelid, orbital, and episcleral lesions, even at a young age.
Effect of Residual Stresses on the Fatigue Stress Range of a Pre-Deformed Stainless Steel AISI 316L Exposed to Combined Loading
Authors: Jagarinec Darko , Gubeljak Nenad
Published: September 2024

AISI 316L austenitic stainless steel is utilized in various processing industries, due to its abrasion resistance, corrosion resistance, and excellent properties over a wide temperature range. The physical and mechanical properties of a material change during the manufacturing process and plastic deformation, e.g., bending. During the combined tensile and bending loading of a structural component, the stress state changes due to the residual stresses and the loading range. To characterize the component’s stress state, the billet was bent to induce residual stress, but a phase transformation to martensite also occurred. The bent billet was subjected to combined tensile–bending and fatigue loading. The experimentally measured the load vs. displacement of the bent billet was compared with the numerical simulations. The results showed that during fatigue loading of the bent billet, both the initial stress state at the critical point and the stress state during the dynamic loading itself must be considered. Analysis was demonstrated only for one single critical point on the surface of the bent billet. The residual stresses due to the phase transformation of austenite to martensite affected the range and ratio of stress. The model for the stress–strain behaviour of the material was established by comparing the experimentally and numerically obtained load vs. displacement curves. Based on the description of the stress–strain behaviour of the pre-deformed material, guidelines have been provided for reducing residual tensile stresses in pre-deformed structural components.
Comparative Study of Steel Mill Dust Leaching with Phosphoric Acid and Sodium Hydroxide
Authors: Sánchez Fernando , de la Torre Ernesto , Guevara Alicia , Moreno Katherine , Aragón-Tobar Carlos F.
Published: September 2024

Steel mill dust (SMD), produced by electric arc furnaces, is a highly polluting industrial waste due to its high content of metals (Zn, Fe, and Pb) and fine particle size (ca. 5.4 µm). This residue can be valorized to recover Zn using pyro and hydrometallurgical methods, with hydrometallurgy offering greater selectivity and lower energy costs. However, composition of SMD presents a challenge in identifying an optimal leaching agent. This study investigates the preferential extraction of Zn using two leaching agents, namely 150 g L−1 (1.5 M) phosphoric acid (H3PO4) and 240 g L−1 (6 M) sodium hydroxide (NaOH), in a two-stage leaching process (80 °C). Metallic Zn from the alkaline pregnant solution was recovered by electrodeposition (750 A/m2, graphite anode, stainless-steel cathode) and smelting (450 °C). The samples of SMD contained 26.3% Zn, 20.1% Fe, and 0.9% Pb, in compounds such as magnetite (Fe3O4), zincite (ZnO), and franklinite (ZnFe2O4). Each leaching agent successfully attained a 99% Zn recovery, demonstrating the proposed procedure’s high efficacy. However, H3PO4 leached also Fe and corroded the cathode during electrodeposition, thereby restricting the final recovery of metallic Zn. NaOH demonstrated greater selectivity for Zn over Fe and Pb, producing high-purity Zn deposits on the cathode by electrodeposition and 99% metallic zinc by smelting.
Deep Learning-Driven Prediction of Mechanical Properties of 316L Stainless Steel Metallographic by Laser Powder Bed Fusion
Authors: Zhang Zhizhou , Mativenga Paul , Zhang Wenhua , Huang Shi-qing
Published: September 2024

This study developed a new metallography–property relationship neural network (MPR-Net) to predict the relationship between the microstructure and mechanical properties of 316L stainless steel built by laser powder bed fusion (LPBF). The accuracy R2 of MPR-Net was 0.96 and 0.91 for tensile strength and Vickers hardness predictions, respectively, based on optical metallurgy images. Feature visualisation methods, such as gradient-weighted class activation mapping (Grad-CAM) and clustering, were employed to interpret the abstract features within the MPR-Net, providing insights into the molten pool morphology and grain formation mechanisms during the LPBF process. Experimental results showed that the optimal process parameters—190 W laser power and 700 mm/s scanning speed—yielded a maximum tensile strength of 762.83 MPa and a Vickers hardness of 253.07 HV0.2 with nearly full densification (99.97%). The study marks the first application of a convolutional neural network (MPR-Net) to predict the mechanical properties of 316L stainless steel samples manufactured through laser powder bed fusion (LPBF) based on metallography. It innovatively employs techniques such as gradient-weighted class activation mapping (Grad-CAM), spatial coherence testing, and clustering to provide deeper insights into the workings of the machine learning model, enhancing the interpretability of complex neural network decisions in material science.
Multi-Position Inertial Alignment Method for Underground Pipelines Using Data Backtracking Based on Single-Axis FOG/MIMU
Authors: Liu Jiachen , Wang Lu , Zu Yutong , Hu Yuanbiao
Published: September 2024

The inertial measurement method of pipelines utilizes a Micro-Electro-Mechanical Systems Inertial Measurement Unit (MIMU) to get the three-dimensional trajectory of underground pipelines. The initial attitude is significant for the inertial measurement method of pipelines. The traditional method to obtain the initial attitude uses three-axis magnetometers to measure the Earth’s magnetic field. However, the magnetic field in urban underground pipelines is intricate, which leads to the initial attitude being inaccurate. To overcome this challenge, a novel multi-position initial alignment method based on data backtracking for a single-axis FOG and a three-axis Micro-Electro-Mechanical Inertial Measurement Unit (MIMU) is proposed. Firstly, the configuration of the sensors is determined. Secondly, according to the three-point support structure of the pipeline measuring instrument, a three-position alignment scheme is designed. Additionally, an initial alignment algorithm using the data backtracking method is developed. In this algorithm, a rough initial alignment is conducted by the data from single-axis FOG, and a fine initial alignment is conducted by the data from FOG/MIMU. Finally, an experiment was conducted to validate this method. The experiment results indicate that the pitch and roll angle errors are less than 0.05°, and the azimuth angle errors are less than 0.2°. This improved the precision of the 3-D trajectory of underground pipelines.
Formation, Structure, Electronic, and Transport Properties of Nitrogen Defects in Graphene and Carbon Nanotubes
Authors: Fujimoto Yoshitaka
Published: September 2024

The substitutional doping of nitrogen is an efficient way to modulate the electronic properties of graphene and carbon nanotubes (CNTs). Therefore, it could enhance their physical and chemical properties as well as offer potential applications. This paper provides an overview of the experimental and theoretical investigations regarding nitrogen-doped graphene and CNTs. The formation of various nitrogen defects in nitrogen-doped graphene and CNTs, which are identified by several observations, is reviewed. The electronic properties and transport characteristics for nitrogen-doped graphene and CNTs are also reviewed for the development of high-performance electronic device applications.
Stress Engineering of Magnetization Fluctuation and Noise Spectra in Low-Barrier Nanomagnets Used as Analog and Binary Stochastic Neurons
Authors: Rahman Rahnuma , Bandyopadhyay Supriyo
Published: September 2024

A single-domain nanomagnet, shaped like a thin elliptical disk with small eccentricity, has a double-well potential profile with two degenerate energy minima separated by a small barrier of a few kT (k = Boltzmann constant and T = absolute temperature). The two minima correspond to the magnetization pointing along the two mutually anti-parallel directions along the major axis of the ellipse. At room temperature, the magnetization fluctuates randomly between the two minima, mimicking telegraph noise. This makes the nanomagnet act as a “binary” stochastic neuron (BSN) with the neuronal state encoded in the magnetization orientation. If the nanomagnet is magnetostrictive, then the barrier can be depressed further by applying (electrically generated) uniaxial stress along the ellipse’s major axis, thereby gradually eroding the double-well shape. When the barrier almost vanishes, the magnetization begins to randomly assume any arbitrary orientation (not just along the major axis), making the nanomagnet act as an “analog” stochastic neuron (ASN). The magnetization fluctuation then begins to increasingly resemble white noise. The full width at half maximum (FWHM) of the noise auto-correlation function decreases with increasing stress, as the fluctuation gradually transforms from telegraph noise to white noise. Consistent with this trend, the noise spectral density exhibits a 1/fβ spectrum (at high frequencies) with β decreasing from 2.00 to 1.88 with increasing stress. Stress can thus not only reconfigure a BSN to an ASN, which has its own applications, but it can also perform “noise engineering”, i.e., tune the auto-correlation function and power spectral density, having applications in signal processing.
Correlation between the Quantity and Type of Dietary Fiber with the Activity in Mexican Patients with Ulcerative Colitis (UC)
Authors: Martínez-Vázquez Sophia Eugenia , Corral-Ceballos José Miguel , Yamamoto-Furusho Jesús K.
Published: September 2024

Background/Objective: Ingestion of dietary fiber can influence in the remission of patients with ulcerative colitis (UC). There are no current recommendations for fiber intake in UC; therefore, we evaluate the association between dietary fiber and the activity of the disease. Methods: Ours is a cross-sectional study in patients with a confirmed diagnosis of UC to whom a 24 h recall was applied; this allowed for the estimation and classification of type of dietary fiber. The patients were divided into two groups: (1) remission and (2) active UC. We analyzed the quantity and type of fiber with the grades of disease activity through Spearman correlation and logistic regression. Results: A total of 152 patients were included; it was found that those with clinically active UC consumed less total fiber (p = 0.016) and insoluble fiber (p = 0.018). Meanwhile, in endoscopic grade, the difference was for insoluble fiber (p = 0.038). Insoluble fiber had an inversely significant correlation with fecal calprotectin levels (r = −0.204; p = 0.018). Logistic regression showed that less than 11 g of insoluble fiber was a risk factor for clinical activity (OR = 2.37; 95% CI 1.107–5.019; p = 0.026). Conclusions: Consumption below the current recommendation of total and insoluble dietary fiber is associated with clinical activity of UC.
Baked Egg Oral Immunotherapy: Current State in Pediatric Age
Authors: Foti Randazzese Simone , Caminiti Lucia , La Rocca Mariarosaria , Italia Cristina , Toscano Fabio , Galletta Francesca , Crisafulli Giuseppe , Manti Sara
Published: September 2024

Hen’s egg allergy is one of the most common food allergies in the Western world, with an increase in recent years. It affects about 9.5% of the pediatric population, and the onset most often occurs before the first year of life. The occurrence of spontaneous oral tolerance acquisition varies among studies, but it is generally high by school age. Nowadays, allergen immunotherapy may represent the only therapeutic strategy able to modify the natural history of hen’s egg allergy. Specifically, many children with hen’s egg allergy may tolerate baked eggs. Food processing, specifically high temperatures, alters the allergenicity of hen’s egg proteins by causing conformational changes in allergen epitopes, which makes them less allergenic. This review aims to discuss the scientific evidence in the field of baked egg oral immunotherapy in hen’s egg-allergic children, with a meticulous examination of the pertinent literature surrounding the subject matter.
The Impact of Body Composition on Mortality and Hospital Length of Stay after Endovascular and Open Aortic Aneurysm Repair: A Retrospective Cohort Study
Authors: Del Giorno Rosaria , Robaldo Alessandro , Astorino Alessia , Gabutti Luca , Chianca Vito , Rizzo Stefania , Riva Francesca , Ettorre Ludovica , Stefanelli Kevyn , Canevascini Reto , Giovannacci Luca , Prouse Giorgio
Published: September 2024

Background: Sarcopenia is an indicator of preoperative frailty and a patient-specific risk factor for poor prognosis in elderly surgical patients. Some studies have explored the prognostic significance of body composition parameters in relation to perioperative mortality after aortic repair and to mid- and long-term survival following endovascular aneurysm repair (EVAR). This study aimed to comprehensively investigate the effects of various body composition parameters, including but not limited to sarcopenia, on short- and long-term mortality as well as the length of hospital stay in two large cohorts of patients undergoing open surgical aortic repair (OSR) or EVAR. Methods: A single-institution retrospective cohort study included patients who underwent EVAR or OSR from January 2010 to December 2017. Several parameters of body composition on axial CT angiography images were analyzed, such as skeletal muscle area (SMA) with derived skeletal muscle index (SMI), visceral adipose tissue (VAT), and subcutaneous adipose tissue (SAT). Results: 477 patients were included: 250 treated by OSR and 227 by EVAR; the mean age was 70.8 years (OSR) and 76.3 years (EVAR), with a mean follow-up of 54 months. Sarcopenia was associated with a prolonged length of hospital stay in EVAR patients but not in OSR patients (β coefficient 3.22; p-value 0.022 vs. β coefficient 0.391; p-value 0.696). Sarcopenia was an elevated one-year mortality risk post-EVAR compared to those without sarcopenia (p-value for the log-rank test 0.05). SMA and SMI were associated with long-term mortality in EVAR patients even after adjusting for multiple confounders (HR 0.98, p-value 0.003; HR 0.97, p-value 0.032). The analysis of the OSR cohort did not show a significant correlation between short- and long-term mortality and sarcopenia indicators. Conclusions: The results suggest that body composition could predict increased mortality and longer hospital stays in patients undergoing EVAR procedures. These findings were not confirmed in the cohort of patients who underwent OSR. Patients with sarcopenia and pre-operative malnutrition should be critically assessed to define the indication for treatment in this predominantly elderly and morbid cohort, despite EVAR procedures being less invasive. Body composition evaluation is an inexpensive and reproducible tool that can contribute to an improved decision-making process by identifying patients who will benefit most from EVAR, ensuring a more personalized and cost-effective treatment strategy. Further studies are planned to explore the added value of integrating body composition into a comprehensive risk stratification before aortic surgery.