bluuebunny/crossref_metadata_2025 huggingface dataset:
Prevalence of Anemia and Admission Outcome Among Anemic Compared to Non-anemic Patients Admitted in Internal Medicine at University Teaching Hospital of Kigali: a Non Randomized Comparative Study.
Authors: Havugimana Phocas , Babane Felix , Ntabanganyimana Etienne , Ntihinyurwa Polyphile , Mushimiyimana Diane , Masaisa Florence
Published: November 2022

Background: Admitted patients with anemia are at increased morbidity and mortality risk as well as length of hospital stay. To the best of our knowledge, there is no study done in Rwanda assessing the prevalence of anemia and admission outcome among admitted patients and few studies are done in sub-Sahara Africa. We aimed to determine the prevalence of anemia in admitted patients but also their length of hospital stay and mortality risk in anemic patients compared to non-anemic patients.
Method: We recruited 143patients at University Teaching Hospital of Kigali between March and April 2021 and follow them up until discharge. Sociodemographic and clinical information was collected for all eligible patients. The associations were tested using chi-square tests. The outcome variable (anemia) was cross tabulated with all factors associated with anemia.
Results: The Prevalence of anemia was 52.4% among 143 enrolled patients and the majority had Normocytic anemia with 41.9%. Hypertension and Diabetes were the most common comorbidities found in 50 (35%) and 37 (25.9%) of respondents respectively. CKD (OR 12.108, p0.001), Cancer (OR 10.488; p 0.027) and HIV/AIDS had higher odds of developing anemia. Mortality rate was 13.3 % in all participants but the mean Hemoglobin of patients who died was lower compared to the mean hemoglobin of patients who were discharged alive with 11.4±4.1g/dL and 12±3.3 g/dL respectively (P-value 0.551). Patients with severe anemia were 4 times more likely to die while mild and moderate anemia did not significantly impact the likelihood of death compared to patients with normal Hemoglobin. Hemoglobin level correlates with the length of hospital stay as the lower the hemoglobin level, the longer the hospital stay was (P-value 0.010).
Conclusion: Anemia is prevalent among in-patients at CHUK patients with CKD, cancers, and HIV/AIDS as leading predisposing factors. Patients with anemia are at increased risk of mortality and longer length of hospital stay compared to those with normal hemoglobin level.
An SDN Architectural Framework for VANET Security and Data Storage
Authors: Priyadarsini Madhukrishna , Bera Padmalochan , Rout Jyotiranjan
Published: November 2022

Vehicular Ad hoc NETworks (VANETs) are an active area of research because of their potential to improve road safety and to enhance traffic efficiency. High dynamic connections, sensitive information sharing, and time-sensitivity nature of VANET make it an eye-catching field for attackers. Software-defined networking (SDN) can be used to implement any network, due to the separation of the control program and data plane. In this paper, we have proposed an SDN architectural framework to enhance the storage capacity and to provide security to prevent specific VANET attacks. The storage capacity is enhanced using B+ tree and the security to the storage is provided using X.509 public key certification. On the other hand, we have used signaling game-theoretic solutions in the architectural framework to prevent the attacks. The framework provides end-to-end security to the communication between devices of VANET. Experimentation results show efficient data retrieval with less computational complexity and 98% attack detection and prevention with high throughput and less delay.
Post-HSCT maintenance treatment using entrectinib for an AML patient accompanied ETV6-NTRK3: a case report
Authors: Zhao Xiaoli , Hao Mengze , Zhang Xiaoyu , Wei Jialin , Feng Sizhou , He Yi , Jiang Erlie , Han Mingzhe
Published: November 2022

The neurotrophic receptor tyrosine kinases (NTRKs) gene fusions occur in many different tumors, and tropomyosin receptor kinase (TRK) inhibitors exhibit attractive antitumor activity. This case report presents that a patient with refractory AML accompanied ETV6-NTRK3 was failed in traditional chemotherapy, then received continue remission after hematopoietic stem cell transplantation (HSCT) and maintenance therapy with entrectinib. This is the first time that TRK inhibitor has been used in patient with AML after HSCT.
Evaluation of dual-trigger regimen in improving outcomes for pregnancy in different ovarian respond patients: a retrospective study
Authors: Wang Jinrong , Xu Ke , Yang Shuangshuang , Hou Ning , Sun Mei
Published: November 2022

Objective
Observing pregnancy outcomes of patients who used dual-trigger and single-trigger regimens in different ovarian responders who received ART, and assessing the effectiveness and safety of the regimens to provide insights into the optimization of clinical strategy.
Methods
The clinical profile of 2778 infertile patients who received ART (IVF/ICSI) were reviewed and collected retrospectively. Patients enrolled with different ovarian responses were divided into single-trigger and dual-trigger groups based on different real-world trigger protocols. The baseline characteristics, ovulation induction and pregnancy outcomes of the patients were statistically analyzed.
Results
There were no significant differences in characteristics of the baseline and cycle parameters on the two trigger regimen groups for high responders, normal responders and low responders. The number of oocytes and the oocytes retrieval rate by the dual trigger of normal responders and high responders have increased, but there were no significant differences in pregnancy outcomes (embryo transfer rate, pregnancy rate, live birth rate) between trigger groups. The dual trigger had a lower transplant cancellation rate due to prevention of OHSS: high responders (P = 0.927), normal responders (P = 0.251). In poor responders, there were no cases of transplantation cancellation for OHSS prevention in both groups.
Conclusion
The dual trigger is a relatively effective and safe regimen for patients with high response and normal ovarian response. In patients with poor ovarian response, the evidence for reducing the risk of OHSS is not sufficient. Further validation in larger, well-designed randomized controlled trials on whether dual triggering improves pregnancy outcomes in poor responders is needed.
Explicit Finite Difference Analysis of Pseudo-Hyperbolic Partial Differential Equations
Authors: Modanli Mahmut , Abdulazeez Sadeq Taha , Akgül Ali
Published: November 2022

The explicit finite difference method is suggested in this publication to resolve pseudo-hyperbolic partial differential equations. An explicit finite difference scheme is developed for the suggested problem. The estimated and exact solutions are compared to create the error analysis table. The stability inequalities for this difference scheme are demonstrated using matrix analysis. An example is illustrated as an implementation of the finite difference scheme method. The results show that the proposed method is very accurate and convenient. The solutions are represented graphically. Other numerical methods can be applied to investigate pseudo-hyperbolic partial differential equations.
In situ diagnostics of the Si etching structures profile in ICP SF6/C4F8 plasma: Macrostructures
Authors: Osipov Artem , Gagaeva Alina , Speshilova Anastasiya , Osipov Armenak , Enns Yakov , Kazakin Alexey , Endiiarova Ekaterina , Kornilov Roman , Alexandrov Sergey
Published: November 2022

In this work we studied the influence of technological parameters of plasma chemical etching of silicon on photoresist etching rate, silicon etching rate, etching selectivity of silicon in relation to photoresist, and inclination angle of the profile wall of the etched windows. Based on the obtained results, a common regularity between the inclination angle of the profile wall of the etched windows and the optical emission spectra was revealed. The method of in situ diagnostics was proposed, namely, controlling the inclination angle of the profile wall of the etched windows by the ratio of the emission intensities of the carbon line (517.1 nm) to the fluorine line (685.8 nm and 703.9 nm) designated as parameter X. It was found that the inclination angle of the profile wall of the etched windows takes certain values depending on the value of the X parameter. The ranges of X values, at which the inclination angle of the profile wall of the etched windows is acute, right, and obtuse are estimated. So, at values of X from ≈0.15 to ≈0.35 the acute angle (from 81±0.5° to 89±0.5°) is obtained, at X from ≈0.35 to ≈0.42 the right angle is obtained (90±0.5°), and at X from ≈0.42 to ≈0.75 the values of the inclination angle of the profile wall of the etched windows are in the range from 91±0.5° to 94±0.5°, no matter which technological parameters were set. Experiments were conducted for etching windows with linear dimensions from 0.5x20 mm to 2x20 mm.
Prophylactic muscle injection treatment for fatty degeneration in rotator cuff injury: A systematic review of animal studies
Authors: Nihei Kota , Murata Kenji , Sone Kenta , Nagata Shiori , Kawabata Sora , Kojima Takuma , Takasu Chiharu , Terada Hidenobu
Published: November 2022

Introduction: Fatty degeneration is the most important factor affecting massive rotator cuff tear (RCT) function. However, the mechanism underlying fatty degeneration and treatment after massive rotator cuff injury remains to be elucidated. This study sought to systematically scoping review published animal studies to explore effective treatment options for fatty degeneration following human rotator cuff injury, focusing on fibro-adipogenic progenitor (FAP).
Materials and methods: MEDLINE, PubMed, and Embase were systematically searched for articles published in June 2022, using relevant keywords. Animal species, injury and repair types, study duration, and fatty degeneration parameters were summarized.
Results: Of the 120 studies, 51 were secondarily evaluated for cell treatment of fatty degeneration in rotator cuff injury. Finally, 6 studies examining the effects of FAP on fatty degeneration were selected for analysis. Six studies showed positive effects on the SS muscle following fibro/adipogenic progenitor (FAP) (n = 3) or pluripotent stem cell (n = 3) injections.
Conclusion: Following the review, we concluded the following: 1) FAP cell injections effectively inhibit fatty degeneration after rotator cuff injury.
Level of evidence: Level IV, review article.
Repercussion of Conflicts caused through Chemical Defilement and Eradication in Contemporary Existence
Authors: Katke Sai
Published: November 2022

Conflicts can occur as a result of any natural phenomena or any man-made activity that causes anguish in human brains; comprehending chemical contamination and elimination is the goal for global security. Many worldwide conferences attempt to balance and regulate such incidents; yet, prolonging any such event is a monumental task; however, and therefore learning and preventing for knowledge of any repercussions is a debate. It is difficult to summarize chemical conflicts, hazards, toxic gases, weapons, warfare, chemical mixtures/compositions contamination, conversions, and so on. We have covered briefly their literature, repercussions, risks, and preventions for any confrontations resulting in chemical outbursts below.
How Do Logistics Disruptions Affect Rural Households? Evidence from COVID-19 in China
Authors: Huang Difang , Chen Muzi , Nan Li
Published: November 2022

Using a comprehensive survey of households during the early stage of the COVID-19 pandemic in China, we find that logistics disruptions due to the lockdown have resulted in severe economic losses for rural households. Further analysis shows that storage of agricultural inputs and outputs, insurance, and macroeconomic factors are associated with such losses during this period. We further examine the mechanisms by which logistics disruptions affect rural households, including both sales and production channels in agricultural supply chains. The former includes changes in product prices and reduced sales, while the latter includes changes in input prices and shortages of raw materials, capital, and labor. Of these channels, logistics has the most severe impact on sales. Opening up the logistics of sales channels is the primary policy choice. More storage warehouses and insurance are also important preemptive measures. Building stable and sustainable agricultural supply chains ensure rural households' production during the pandemic.
Convolutional Neural Networks Trained to Identify Words Provide a Good Account of Visual Form Priming Effects
Authors: Yin Dong , Bowers Jeffrey , Biscione Valerio
Published: November 2022

A wide variety of orthographic coding schemes and models of visual word identification have been developed to account for masked priming data that provide a measure of orthographic similarity between letter strings. These models tend to include hand-coded orthographic representations with single unit coding for specific forms of knowledge (e.g., units coding for a letter in a given position or a letter sequence). Here we assess how well a range of these coding schemes and models account for the pattern of form priming effects taken from the Form Priming Project and compare these findings to results observed in with 11 standard deep neural network models (DNNs) developed in computer science. We find that deep convolutional networks perform as well or better than the coding schemes and word recognition models, whereas transformer networks did less well. The success of convolutional networks is remarkable as their architectures were not developed to support word recognition (they were designed to perform well on object recognition) and they classify pixel images of words (rather artificial encodings of letter strings). The findings add to the recent work of (Hannagan et al., 2021) suggesting that convolutional networks may capture key aspects of visual word identification.
The estimation of coronary artery calcium thickness by computed tomography angiography based on optical coherence tomography measurements
Authors: Okutsu Masaaki , Mitomo Satoru , Onishi Hirokazu , Nakajima Akihiro , Yabushita Hiroto , Matsuoka Satoshi , Kawamoto Hiroyoshi , Watanabe Yusuke , Tanaka Kentaro , Naganuma Toru , Tahara Satoko , Nakamura Shotaro , Basavarajaiah Sandeep , Nakamura Sunao
Published: November 2022

Purpose
Optical coherence tomography (OCT) is recommended to be the most appropriate modality in assessing calcium thickness, however, it has limitations associated with infrared attenuation. Although coronary computed tomography angiography (CCTA) detects calcification, it has low resolution and hence not recommended to measure the calcium size. The aim of this study was to devise a simple algorithm to estimate calcium thickness based on the CCTA image.
Methods
Consecutive patient who had CCTA for suspected coronary artery disease and subsequently went on to have OCT were included in the study. Calcium CT density was collected from CT profile curve. The method to estimate calcium thickness was devised from maximum CT density within the calcification and compared to the measured calcium thickness by OCT. The accuracy of this method was compared to full width at half maximum (FWHM) or inflection point (IP) method.
Results
A total of 68-patients (238-lesions) divided into derivation and validation dataset at 2:1 ratio (47 patients with 159 lesions and 21 with 79, respectively) were analyzed. Maximum Calcium density and measured calcium-border CT density had a good correlation with a linear equation of y = 0.58x + 201 (r = 0.892, 95% CI: 0.855–0.919, p < 0.001). The estimated calcium thickness derived from this equation showed strong agreement with measured calcium thickness in validation and derivation dataset (r2 = 0.481 and 0.527, 95% CI: 0.609–0.842 and 0.497–0.782, p < 0.001 in both, respectively), more accurate than the estimation by FWHM and IP method.
Conclusion
This novel method provided the estimation of calcium thickness more accurately than conventional methods.
Activated volcanism of Mount Fuji by the 2011 Japanese large earthquakes
Authors: Nanjo Kazuyoshi , Yukutake Yohei , Kumazawa Takao
Published: November 2022

The relation between earthquakes and volcanic eruptions, each of which is manifested by large-scale tectonic plate and mantle motions1, has been widely discussed2-7. Mount Fuji in Japan last erupted in 1707, paired with a magnitude (M)-9-class earthquake that took place 49 days prior8-10. Motivated by this pairing, previous studies examined the effect of both the 2011 M9 Tohoku megaquake and a triggered M6-class earthquake 4 days later at the foot of the volcano on Mount Fuji, although no volcanic eruption was reported11,12. More than 300 years already have passed since the last 1707 eruption, and although consequences to humans and society caused by the next eruption are already being considered, the implication for future volcanism remains uncertain. Here we show how volcanic low-frequency earthquakes (LFEs)14-18 in the deep part of the volcano revealed hitherto-unrecognized activation immediately after the foot earthquake. Our analyses19-27 showed that despite an increase in the rate of occurrence of LFEs, these did not return to pre-earthquake levels, indicating a change in the magma system. Our results demonstrate that the volcanism of Mount Fuji was reactivated by the foot earthquake, implying that this volcano is sufficiently sensitive to external events that are enough to trigger eruptions.
The causal involvement of the BDNF-TrkB pathway in dentate gyrus in early-life stress-induced cognitive deficits
Authors: Li Ji-Tao , Sun Yaxin , Su Yun-Ai , Wang Qi , Wang Ting , Zheng Jia-Ya , Zhang Chen-Chen , Liu Xiao , Ma Yu-Nu , Li Xue-Xin , Zhang Xianqiang , Xie Xiaomeng , Si Tian-Mei
Published: November 2022

Cognitive dysfunction is a signiﬁcant, untreated clinical need in patients with psychiatric disorders, for which preclinical studies are needed to understand the underlying mechanisms and to identify potential therapeutic targets. Early-life stress (ELS) leads to long-lasting deficits of hippocampus-dependent learning and memory in adult mice, which may be associated with the hypofunction of the brain-derived neurotrophic factor (BDNF) and its high-affinity receptor, tropomyosin receptor kinase B (TrkB). In this study, we carried out eight experiments to examine the causal involvement of the BDNF-TrkB pathway in dentate gyrus (DG) and the therapeutic effects of the TrkB agonist (7,8-DHF) in ELS-induced cognitive deficits. Adopting the limited nesting and beding material paradigm, we first demonstrated that ELS impaired spatial memory, suppressed BDNF expression and neurogenesis in DG in adult mice. Down-regulating BDNF expression (conditional BDNF knockdown) or inhibition of the TrkB receptor (using its anatognist ANA-12) in the DG mimicked the cognitive deficits of ELS. Acute up-regulation of BDNF (exogenous human recombinant BDNF microinjection) levels or activation of TrkB receptor (using its agonist, 7,8-DHF) in the DG restored ELS-induced spatial memory loss. Finally, acute and subchronic systemic administration of 7,8-DHF successfully restored spatial memory loss in stressed mice. Subchronic 7,8-DHF treatment also reversed ELS-induced neurogenesis reduction. Our findings highlight BDNF-TrkB system as the molecular target of ELS-induced spatial memory deficits and provide translational evidence for the intervention at this system in the treatment of cognitive deficits in stress-related psychiatric disorders, such as major depressive disorder.
The effect of caspase-8 as an apoptotic marker in relation to COVID-19 patients severity
Authors: Eyada Zainab Noaman , Al-Timimi Raid J. M. , alkubaisi haitham , Abdulateef Yasir .M
Published: November 2022

Objective: In Iraq, the COVID-19 pandemic was catastrophic, leading to mortality and morbidity. One of the leading causes of mortality was cell apoptosis that leads to organ failure.
Aim: To diagnose the cell apoptosis of COVID-19 patients at an early stage so we can predict earlier organ failure.
Methods: The research was conducted in the medicinal chemistry department of Al-Nahrain University/College of Medicine in Baghdad, Iraq. One hundred patients of different stages proved COVID-19 and compared with 100 persons in the control group, measure caspase-8 enzyme and acute inflammatory markers, procalcitonin (PCT), and IL-6 with COVID-19 immunoglobulins IgG, IgM in the blood of two groups. We're done—statical studies with clinical analysis results.
Results: The marker of cell apoptosis was caspase-8 enzymes, which showed vertical elevation with the increase in severity of COVID-19 patients. There was a strong relationship between the caspase-8 enzyme and acute inflammatory markers. Moreover, there is a relationship between the caspase-8 enzyme and COVID-19 immunoglobulins.
Conclusion: The caspase-8 enzyme is a strong marker of severity in COVID-19 patients and indicates a life-threatening condition.
An assessment of volatility and leverage effect before and during the period of Covid-19: a study of selected international stock markets
Authors: Bhunia Amalendu , Ganguly Soumya
Published: November 2022

This research work assesses the volatility and leverage effect of the selected stock markets before and during the outburst of the Covid-19 of the selected international stock markets. This study is based on daily time-series data obtained from yahoo.finance database. The period of the study has been considered from 1 September 2019 to 31 December 2019, before the period of Covid-19, and from 1 January 2020 to 30 April 2020, during the period of Covid-19. In the course of analysis, descriptive statistics, the GARCH model, the EGARCH model, and the TGARCH model have been used. The GARCH test results show that volatility existed before and during the period of Covid-19. Both E-GARCH and T-GARCH test results show that the leverage effect existed before and during the period of Covid-19. So, the impact of the Covid-19 pandemic in terms of bad news has a bigger influence on international stock markets.
The emergent pattern of infant stage ocean warming in satellite measurements
Authors: Yang Hu , Lohmann Gerrit , Stepanek Christian , Wang Qiang , Huang Rui Xin , Shi Xiaoxu , Liu Jiping , Chen Dake , Wang Xulong , Zhong Yi , Yang Qinghua , Bao Ying , Müller Juliane
Published: November 2022

Satellite-observed sea surface temperature (SST) provides an unprecedented opportunity to evaluate the ongoing global warming and has recently reached a milestone of 40 years temporal coverage. One of the major warming patterns captured by satellites is relatively strong subtropical ocean warming across all ocean basins. This pattern was widely interpreted as a manifestation of the Pacific Decadal Oscillation, a natural climate variability. However, we find that the observed warming pattern, characterized by strong warming over the subtropical oceans and mild warming or even cooling over the subpolar oceans, is dynamically consistent with where the surface water converges and diverges. By comparing observations with paleo-reconstructions and simulated short-term and long-term SST response to CO2 forcing, we propose that the observed warming pattern is likely in a transient early warming stage constrained by background ocean circulation. In the long term, ocean warming at high latitudes is expected to exceed the temporally dominating subtropical ocean warming. The committed, but lagged, high-latitude ocean warming has potential to reshape the ocean-atmosphere circulation and threaten the stability of marine-terminating ice sheets.
Fusion, Micronization and Bio-activated (FMB) extract of Gymnema sylvestre for higher antidiabetic and antioxidant effects compared to its conventional standardized extract
Authors: Ibrahim Mohammad , Gokarn Vijay , Tamoli Sanjay
Published: November 2022

Despite considerable studies, diabetes continues to remain a challenge for its prevention and management with an increasing rate of morbidity and mortality. One of the popular herbal extracts - Gymnema sylvestre has been extensively studied for its anti-diabetic potential. The present study aimed to explore the in vitro antidiabetic and antioxidant effects of Gymnema sylvetsre (Gudmar; GD) and also reveal its drug-likeness, toxicity and action mechanism by utilizing in silico molecular docking and network pharmacology, respectively. The elemental analysis confirmed that FMB technology successfully replenishes iron, zinc and calcium in the conventional extract which is devoid of these essential trace elements. GD extract-FMB (IC50 = 131.90 ± 0.44) are more effective as compared to conventional GD extract in the case of α-amylase (IC50 = 118.23 ± 0.42; IC50 = 109.52 ± 0.34) and α-glucosidase (IC50 = 109.52 ± 0.34), respectively while a similar effect was observed in DPPH-free radical scavenging (IC50 = 129.2 ± 0.98) of GD extract-FMB as compared to GD extract (IC50 = 176.6 ± 0.51). Network pharmacology revealed that key target proteins that are strongly linked to iron, zinc and calcium were strongly involved in glucose metabolism, oxo-inflammatory responses and insulin-related pathways. In addition, in silico molecular docking results of gymnemic acid against α-amylase and α-glucosidase revealed strong biological bindings. Conclusively, based on the finding we can conclude that FMB technique replenish the ETEs in the conventional extract. Also FMB processing is beneficial and provides a innovative solution for the herbal pharmaceutical industry to develop better efficacious extracts or herbal formulations.
Les faits établis par des accords étrangers et des rapports internes - une base valide pour une décision pénale suisse ?
Authors: Capus Nadja , Nunnari Basilio
Published: November 2022

Les jugements des grandes affaires de corruption transnationale et de blanchiment d'argent font apparaître une nouvelle pratique qui consiste à établir les faits sur la base du contenu des transactions pénales judiciaires. À partir d'un cas actuel concernant Gulnara Karimova, nous identifions concrètement deux méthodes: d'une part, la communication et la transplantation transnationale des faits qui ont été établis dans des procédures de négociation (des accords) conclues à l'étranger et, d'autre part, le recours à des rapports internes. Cette contribution décrit ce phénomène, la problématique juridique et les préoccupations pratiques y relatives, en particulier quant à l'admissibilité et la valeur probante du contenu des accords et des rapports internes.

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Die Urteile in umfangreichen Fällen grenzüberschreitender Korruption und Geldwäsche lassen eine neue Praxis erkennen, die darin besteht, Sachverhalte auf der Grundlage des Inhalts von Absprachen zu ermitteln. Anhand eines aktuellen Falles betreffend Gulnara Karimova werden zwei konkrete Methoden dieser Vorgehensweise identifiziert: zum einen die transnationale Kommunikation und schlichte Übernahme von Fakten, die in ausländischen Absprachen ausgehandelt wurden, und zum anderen der Rückgriff auf interne Berichte. Dieser Beitrag beschreibt das Phänomen, erläutert die rechtliche Problematik und die praktischen Bedenken, insbesondere in Bezug auf die Zulässigkeit und den Beweiswert des Inhalts der Absprachen und internen Berichten.
Relationship between Social Media Addiction Levels and Academic Procrastination among Undergraduate Students in Malaysia: Grit as the Mediator
Authors: Ch'ng Lena Tzyy Xian , Soo Hoo Pei Ying
Published: November 2022

The current study examines grit as a mediator in the relationship between social media addiction and academic procrastination. Social media platforms were used to recruit 88 young adult undergraduates aged 18-26. This study was a non-experimental, correlational mediation design. Participants were asked to complete the Social Media Addiction Scale – Student Form, Academic Procrastination Scale – Short Form, and Short Grit Scale questionnaires. It was hypothesized that grit would be a statistical mediator for the effects of social media addiction on academic procrastination. The hypothesis was supported as results showed a full mediation. The current study suggests that social media addiction predicts lower level of grit and thus higher tendency of academic procrastination. It is advised that institutions encourage undergraduates to cultivate grit in order to break the vicious cycle of social media addiction and academic procrastination.
The Future of Psychotherapy for Youth
Authors: Spiro Caleb , Economou Peter
Published: November 2022

Despite countless modifications to adapt adult psychotherapy to treat pediatric populations, recent meta-analytic findings have found only modest effect sizes for the treatment of pediatric depression. Additionally, recent neuroscientific evidence suggests that most mental health disorders share greater comorbidity with other distinct mental health disorders and also have greater within-disorder heterogeneity than previously thought. This review aims to integrate recent findings of analytic reviews with developments in neuroscience to encourage the field to think differently about how to best improve pediatric psychotherapy and our understanding of the developing brain. This article examines why our approach to treating mood disorders in the pediatric population must change based on our current understanding of the neurocognitive and psychosocial etiologies of these disorders and to highlight the importance transdiagnostic perspectives. Perhaps, neuroscientific methods can one day become adjunctive to psychotherapy to help personalize approaches, and to help provide valuable insight into emerging psychopathology even before symptoms manifest.
Key factors influencing the development of the chocolate market
Authors: Ryzhakova A. V. , Goloviznin I. V.
Published: November 2022

The modern consumer is becoming an increasingly active and selective shopper every year. According to the Deloitte consumer research center, 38% of Russian consumers prefer to visit stores even when they are not in dire need. It is important for such consumers to see new products on the shelf, study them and make a decision about buying such goods in the short term, taking into account all the information on the labeling. To a large extent, the consumer sector is influenced by global trends, which are reflected in domestic consumption due to their popularity among customers through promotion through social networks in the context of a healthy lifestyle and support from manufacturers and retailers through the production and introduction of "trendy" products into the production and assortment matrix. In this regard, confectionery products in general and chocolate, as a significant product in the volume of industry revenues at the expense of value, are becoming one of the most studied product categories by consumers. This is due to innovations within the category and the impact of the consumption of calorie products on the health and appearance of the consumer.
Assessment of CHINA'S contribution to the development of the russian electric power industry: from planned to implemented projects
Authors: Wang Ji Lu
Published: November 2022

Modern energy cooperation between Russia and China is mutually beneficial and complementary: China invests in the implementation of Russian energy projects, and Russia, in turn, supplies its energy resources to China, meeting the needs of both sides. This article assesses China's contribution to the development of the Russian electric power industry. The assessment is carried out on the basis of careful examination of upcoming and already implemented projects of China's investment cooperation in Russia in the field of renewable energy, including solar, wind, and hydropower, as well as in the field of thermal and nuclear energy. At the same time attention is paid to the volume of investment in specific projects, and the degree of participation in the equity holding. Based on the results of the assessment, a conclusion is made about the high interest of China in the implementation of electric power projects in Russia. China especially counts on mutual support for cooperation in the field of renewable energy, namely in the sector of construction of solar, wind and hydropower plants, in order to solve the climate issue. At the same time China does not deny the importance of developing relations in the field of oil and gas.
Hibernation or Transformation? Challenges in Cardiovascular Drug Development
Authors: Mercanoglu G. , Mercanoglu F.
Published: November 2022

The decline in deaths from cardiovascular diseases in line with scientific
developments between 1950-2010 was impressive. Despite these significant advances,
cardiovascular (CV) diseases remain the leading cause of death worldwide. According
to the World Health Organization (WHO) data, 17.9 million people die due to CV
diseases every year, which corresponds to 31% of the total deaths worldwide.
Therefore, for many CV diseases, there is still a need for improved treatment, and this
is only possible with the development of new drugs.
Although investments in the previous decade have resulted in the development of many
innovative drugs in the treatment of CV diseases, today, pharmaceutical companies are
less enthusiastic about developing CV drugs, mainly due to financial and regulatory
difficulties. Indeed, today, institutes, associations and even organizations such as WHO
are taking over the sponsorship role that pharmaceutical industry players have
abandoned. In parallel, cardiovascular pipeline activity is shifting from large
pharmaceutical companies to small and medium-sized companies and from fast following drugs to first-in classes. This transformation in CV drug discovery and
development reveals significant challenges that require square up to. The aim of this
chapter is to discuss the global challenges faced in CV drug discovery and development
to find effective solutions.
existence of Ngusaba Bukakak Tradition in modern era
Authors: Suwirya I Komang , Yasa Wayan Suka , Dharmika Ida Bagus
Published: November 2022

The Ngusaba Bukakak tradition is Ngusaba Bukakak tradition which was carried out in Giri Emas Village, Sawan District, Buleleng Regency, which continues to exist in the midst of the swift currents of modernization. In fact, until now this tradition is still carried out by the community well and lively every 2 years at the full moon at Sasih Kedasa. This tradition is beneficial for welfare and prosperity. Therefore, the phenomenon of the Ngusaba Bukakak Tradition is very interesting to study. This study focuses on: (1) The factors that cause the NUSaba Bukakak tradition to continue to exist, amidst the strong influence of modernization. (2) forms of carrying out the Ngusaba Bukakak tradition. (3) the implications of the implementation of the Ngusaba Bukakak tradition for social, cultural, economic, and religious life. The purpose of this research was to explore and study further related to the implementation of the Ngusaba Bukakak tradition which still exists. The theories used in this study include: first, the theory of phenomenology which is eclectic with social and construction theory, second, the theory of religion is eclectic with the theory of religion and culture, third, the theory of reception discusses human works.
Especies arbustivas con potencial forrajero en el trópico altoandino. Manual para actores del sector agropecuario
Authors: Cardona Iglesias Juan Leonardo , Castro Rincón Edwin , Guatusmal Carolina , Valenzuela Martín , Ríos Peña Lina Marcela , Urbano Estrada María Fernanda
Published: November 2022

Las consecuencias del cambio climático se observan en los campos del mundo. Los cambios en el aumento de la temperatura y los patrones climáticos vienen ocasionando grandes pérdidas de cosechas y de productos pecuarios, debido a la aparición de plagas y enfermedades en los cultivos, el deterioro de los suelos y la falta de alimento para los animales. En el trópico altoandino, y producto de la variabilidad climática, se presenta el fenómeno conocido como “estacionalidad forrajera”, que hace que, en los sistemas ganaderos, la cantidad y la calidad de alimento para el ganado disminuya ostensiblemente. Los sistemas silvopastoriles propician el uso de arbustivas forrajeras, especies vegetales con un potencial reconocido para mejorar la alimentación del ganado, recuperar suelos y fuentes hídricas, así como mitigar el impacto del clima sobre los sistemas pastoriles basados en forrajes. En este manual se ofrecen recomendaciones sobre el manejo y uso de varias especies arbustivas forrajeras con potencial para la ganadería del trópico alto colombiano, basados en caracterizaciones e investigaciones realizadas por AGROSAVIA.
Los grados brix como herramienta para determinar el potencial nutricional en forrajes
Authors: Cardona Iglesias Juan Leonardo , Castro Rincón Edwin , Suárez Paternina Emiro Andrés
Published: November 2022

Las consecuencias del cambio climático se observan en los campos del mundo. Los cambios en el aumento de la temperatura y los patrones climáticos vienen ocasionando grandes pérdidas de cosechas y de productos pecuarios, debido a la aparición de plagas y enfermedades en los cultivos, el deterioro de los suelos y la falta de alimento para los animales. En el trópico altoandino, y producto de la variabilidad climática, se presenta el fenómeno conocido como “estacionalidad forrajera”, que hace que, en los sistemas ganaderos, la cantidad y la calidad de alimento para el ganado disminuya ostensiblemente. Los sistemas silvopastoriles propician el uso de arbustivas forrajeras, especies vegetales con un potencial reconocido para mejorar la alimentación del ganado, recuperar suelos y fuentes hídricas, así como mitigar el impacto del clima sobre los sistemas pastoriles basados en forrajes. En este manual se ofrecen recomendaciones sobre el manejo y uso de varias especies arbustivas forrajeras con potencial para la ganadería del trópico alto colombiano, basados en caracterizaciones e investigaciones realizadas por AGROSAVIA.
Makna Simbolik Negara Ngalengka dalam Seni Wayang, Kajian Filsafat Manusia
Authors: Budisutrisna Budisutrisna , Jirzanah Jirzanah
Published: November 2022

Sejarah telah mencatat bahwa wayang telah memiliki usia yang cukup tua. Walau pun demikian seiring dengan berjalannya waktu wayang masih dapat mempertahankan eksistensinya. Wayang masih dapat diterima di tengah-tengah masyarakat. Hal ini disebabkan wayang memiliki sifat yang terbuka terhadap perkembangan zaman. Wayang memiliki sifat yang elastis dengan selalu tetap berpegang teguh kepada pakem seni wayang. Pada zaman sekarang ini pun wayang masih banyak penggemarnya. Salah satu penyebabnya karena kandungan makna simbolik yang banyak di dalamnya. Negara Ngalengka sebagai bagian dari seni wayang juga mengandung makna simbolik. Penelitian ini merupakan penelitian kepustakaan. Metode analisis yang dipergunakan dalam penelitian ini adalah metode hermeneutik filosofis dengan unsur-unsurnya yakni: deskripsi, kesinambungan historis, dan refleksi. Hasil penelitian menunjukkan bahwa Negara Ngalengka mengandung makna simbolik yang berkaitan dengan kehidupan manusia dalam mencapai hidup utama. Dalam mencapai hidup utama manusia selalu mendapatkan rintangan sifat-sifat jiwa manusia yang buruk yang di lambangkan dengan tokoh-tokoh Negara Ngalengka. Sifat-sifat yang buruk itu harus selalu ditindas terus-menerus guna mencapai keutamaan hidup.
Some Aspects of Respect and Dignity of Individual On the Europeanism as Values-system: Moral and Individual
Authors: Karikó Sándor
Published: November 2022

The most philosophical writer of the 20th century, Robert Musil wrote: the individual is nothing else but one’s own primary performance. God has become Deus absconditus—claims Milan Kundera—humans have become all’s stone. In this matter, Europeanism signifies that the individual becomes what one makes oneself become. I think the great challenge of pedagogy (from theoretical and practical aspect aspect): how can the ability and competence of independent thinking be realised during educational work? How does the schooling system facilitate the development of the autonomy of pupils, students and teachers? In my opinion (summary of this study) the respect and dignity are the most beautiful and charming quests of Europeanism and education.
Application of the Scale for Total Impression of Drawings for the Tree-drawing Test
Authors: Hibarino Tomoe , Kato Daiki
Published: November 2022

The purpose of this study is to investigate the application of the Scale for Total Impression of Drawings (STID) in the assessment of the tree-drawing test. Forty-three tree-drawing tests were evaluated by three raters using the STID. The validity of the factor structure was examined using confirmatory factor analysis (CFA). A three-factor model of “vitality” (? = 0.90), “gentleness” (? = 0.89), and “reality” (? = 0.89) was confirmed and the fit indexes were adequate (CFI =.984, RMSEA =.076).
The Alienation of Women in the Context of Social Reproduction
Authors: Duan Jiale
Published: November 2022

As a wave of women’s liberation movements has swept across the world over the past century, Marxist feminism has examined the theories and concepts found in classic Marxist literature, providing an in-depth critique of the importance and alienation of women in the context of social reproduction. An analysis of the different positions of women in social reproduction identifies the mechanisms underlying the alienation of women’s ‘motherhood’ into ‘motherhood’ in the context of social reproduction. The Marxist feminist examination of this alienation is based on an emphasis on women’s biological differences, followed by a division between the public and private spheres, examining the oppression of women in the domestic sphere in terms of both intergenerational alternation and domestic work and the public sphere in terms of the exploitation of women’s participation in social production.
Drill Sealing, Endodontic Retreatment and Fixed Prosthesis Installation in a Lower Molar - Clinical Case Study
Authors: Rocha Beatriz Souza , Martins Lucas Rodrigues , Fuguta Mariana Saquetim , Marques Eduardo Fernandes
Published: November 2022

The access ionization attempt may occur during the coronary period, which may lead to a posterior dental access. The maintenance of the primary tooth is important, especially in cases of permanent tooth agenesis. The aim of this study is to report a clinical case about perforation sealing, endodontic retreatment, and installation of a fixed prosthesis in a lower molar. A patient was selected from the dental clinic of Fapac/Itpac Porto Nacional - TO, asymptomatic, negative sensitivity test and vertical percussion, need for retreatment and perforation in the furcation region. In the first session, anesthesia, access surgery, absolute isolation, irrigation with 2% chlorhexidine gel, identification of the perforation and its conditioning, odontometry, removal of gutta percha with rotary instruments (Logic RT system), drying and insertion of intracanal medication (calcium hydroxide) in root canals and perforation. In the second session (after 15 days), the intracanal medication was removed and the root canals were filled with gutta percha and plasticized technique, and the perforation was sealed with mineral trioxide aggregate (MTA). The clinical case was continued for 2 years, and during the follow-up, asymptomatic, periodontal tissues were clinically and radiographically normal and the dental element performed its masticatory functions satisfactorily. It is possible to conclude with this clinical case that even with a perforation in the furcation region and the need to insert a prosthetic rehabilitation in the dental element, the sealing of the perforation with the aggregate mineral trioxide allowed the maintenance of the dental element.
Stabilization of Black Cotton Soil Using RBI Grade 81 and Sodium Silicate
Authors: Kalyan Ch. D. V. , Sivanarayana Mr. Ch.
Published: November 2022

Abstract: Nearly 51.8 million hectares of land area in India is covered with expansive soils (mainly Black Cotton soil). The property of the expansive soils, in general, is that they are very hard when in dry state, but they lose all of their strength when in wet state. In light of this property of expansive soils, these soils pose problems worldwide that serve as challenge to overcome for the Geotechnical Engineers. One of the most important aspects for construction purpose issoil stabilization, which is used widely in foundation and road pavement constructions; this is because such a stabilization regime improves engineering properties of the soil, such as volume stability, strength and durability. In this process, removal or replacing of the problematic soil is done; replacement is done by a better quality material, or the soil is treatedwith additives. In the present study, RBI Grade 81 obtained from Alchemist Touchnology Limited, Gurgaon, Haryana and Sodium Silicate solution 5mol/Liter obtained from Organ Refractories, Khammam, Telangana are used for the stabilization of black cotton soil. These additives are added in various proportions
Design and Analysis of Mini Fire Fighting Robot
Authors: Singh Priyanshu , Solanki Ankit , Paras Priyanshu , Soni Devendra , Bhavsar Shreya , Dubey Suveer
Published: November 2022

Abstract: Fire Incident is a disaster that can potentially cause the loss of life, property damage and permanent disability to the affected victim. The Victim of Fire Incident can also suffer from prolonged psychological and trauma. Fire fighters are primarily tasked to handle fire incidents, but they are often exposed to higher risks when extinguishing fire, especially in hazardous environments such as in nuclear power plant, petroleum refineries and gas tanks. They are also faced with other difficulties, particularly if fire occurs in narrow and restricted places, as it is necessary to explore the ruins of buildings and obstacles to extinguish the fire and save the victim. With high barriers and risks in fire extinguishment operations, technological innovations can be utilized to assist firefighting. Therefore, this paper presents the design of a firefighting robot dubbed that can extinguish fire without the need for fire fighters to be exposed to unnecessary danger. It is designed to be compact in size than other conventional fire-fighting robot to ease small location entry for deeper reach of extinguishing fire in narrow space. It is also equipped with an ultrasonic sensor to avoid it from hitting any obstacle and surrounding objects, while a flame sensor is attached for fire detection. This resulted in It demonstrating capabilities of identifying fire locations automatically and ability to extinguish fire remotely at distance
Twitter Analysis On Real Time Data
Authors: Sir Prof. Ravishankar , Bhamanage Prathamesh P. , Patil Pratik S. , Ahire Suraj Y. , Jadhav Durgesh P.
Published: November 2022

Abstract: Sentiment analysis is mainly concerned with identifying and classifying opinions or emotions that are expressed within a text. These days, sharing opinions and expressing emotions through social networking websites has become very common. This paper presents an idea of extracting sentiments out of the tweet and an approach towards classifying a tweet into positive, negative or neutral. This approach can be in many ways useful to any organization, who gets mentioned or tagged in a tweet. Generally the tweets being unstructured in format, first of all the tweet needs to be converted into the structured format. In this paper, tweets are resolved using pre-processing phase and access of tweets has been accomplished via libraries using Twitter API.. We provide additional comparisons and extract alternatives. exams, apprenticeships, etc., are compared to find higher overall performance, and several scoring criteria have been developed for different techniques.