bluuebunny/crossref_metadata_2025 huggingface dataset:
Desarrollo agrícola y uso de agroquímicos en el valle de Mexicali
Authors: Moreno Mena José A. , López Limón Mercedes Gema
Published: April 2020

Este trabajo se presenta una propuesta de periodización histórica del uso de plaguicidas y otros agroquímicos en el valle de Mexicali, tomando en cuenta la evolución del desarrollo agrícola en la región y su contexto. El uso de una diversidad de productos químicos en la agricultura ha sido resultado de los modelos tecnológicos industriales que se han adoptado desde principios de siglo, especialmente de las sugerencias de la “revolución verde”. Se resalta la importancia que están teniendo las hortalizas como consumidoras de plaguicidas. También se observa que a pesar de que por varias décadas se han usado agroquímicos en la agricultura del valle mexicalense, son escasas las investigaciones sobre su impacto en la salud pública y en el medio ambiente. Lo que se conoce por estudios realizados en zonas agrícolas que utilizan estos productos es preocupante, por lo que se propone la necesidad de realizar estudios que tiendan a profundizar en esa problemática.
Estancamiento y desaliento del desarrollo productivo en la región agrícola del Valle de Mexicali, Baja California: un análisis tendencial
Authors: Zavala Álvarez José
Published: April 2020

El propósito de este artículo es mostrar las condiciones y tendencias del desarrollo productivo de la región agrícola del Valle de Mexicali, en Baja California, en el periodo 1983-2001, como medida de aproximación a las condiciones del desarrollo agrícola de la región. El propósito deriva de la hipótesis de que la actividad productiva agrícola en la región ha tenido un comportamiento errático con tendencia al estancamiento; en tal condición, el desarrollo productivo es el punto de partida para analizar el comportamiento de la actividad agrícola a través de la construcción de un análisis de tendencia de seis indicadores: superficie cosechada, rendimiento físico y económico de los principales cultivos, volumen y valor de la producción, y diversificación productiva. Para tal ejercicio analítico se hace uso de un par de instrumentos estadísticos: el análisis de series de tiempo con una función de regresión polinomial y la estimación del índice de concentración de Gini. Los resultados obtenidos permiten concluir el estancamiento y la evolución desalentadora, en general, de la actividad productiva agrícola de la región.
El efecto sustitución y la evolución del costo de vida en la frontera de Uruguay con Brasil
Authors: Correa Alsina Fernando
Published: April 2020

El consumidor que vive próximo a la frontera de Uruguay con Brasil tiene la posibilidad de comprar bienes en ambas márgenes de la misma. Puede sustituir compras de un país hacia el otro según la evolución relativa de los precios. De esta manera, tiene acceso a un menor costo de vida que un consumidor ubicado en el interior del país. Además, si el tipo de cambio real bilateral experimenta fluctuaciones importantes, puede sacar un provecho significativo de su localización. Este trabajo aborda el tema desde un punto de vista teórico y empírico. Por un lado, se presenta una adaptación de la teoría de los índices del costo de vida a la situación planteada. Por otro, las estimaciones realizadas muestran que la ventaja derivada de vivir en la frontera fue muy significativa en la última década.
El desarrollo regional en el estado fronterizo de Sonora, México
Authors: Arroyo Alejandre Jesús , Bracamontes Nevárez Joaquín
Published: April 2020

Este trabajo analiza las desigualdades espaciales en el desarrollo socioeconómico regional de Sonora. Para este propósito, se diseña un modelo estadístico y se recurre a la técnica de análisis factorial de componentes principales, lo que permite estimar un Índice de Desarrollo Socioeconómico Municipal (IDSEM) para el año 2000, lo cual hace evidente la concentración geográfica del desarrollo regional en Sonora. También se especificó un modelo econométrico que permitió identificar los factores que obstaculizan o incentivan el desarrollo socioeconómico de la población en los municipios del Estado. Palabras clave: población, concentración geográfica, estructura industrial, urbanización, Índice de Desarrollo Socioeconómico Municipal.
A Study on the Mechanism of Lavender in the Treatment of Insomnia Based on Network Pharmacology
Authors: Wang Yao , Zou Junbo , Jia Yanzhuo , Liang Yulin , Zhang Xiaofei , Wang Chang-Li , Wang Xiao , Guo Dongyan , Shi Yajun , Yang Ming
Published: April 2020

Aim and Objective:

The common disease of insomnia has complex and diverse clinical
manifestations. Lavender represents an effective treatment of insomnia, but the molecular
mechanism underlying the effectiveness of this treatment is not clear. The purpose of this study is
to investigate the active components, target proteins and molecular pathways of lavender in the
treatment of insomnia, thus explaining its possible mechanism.

Materials and Methods:

Firstly, 54 active components of lavender were identified by gas
chromatography-mass spectrometry (GC-MS). The target protein of lavender was predicted by the
Traditional Chinese Medicine System Pharmacological Database and Analysis Platform and the
SwissTargetPredicating tool, and the target protein of insomnia was predicted by the DisGeNET
and DrugBank databases. Then, the "component-target-disease" network diagram was constructed
using the Cytoscape 3.7.1 software. KEGG and GO enrichments were analyzed using the R
statistical language. Finally, the key target proteins were verified by collecting and verifying the
target protein GEO data using the Discovery Studio 3.5 molecular docking verification software.

Results:

906 target proteins of lavender were predicted by the Traditional Chinese Medicine
System Pharmacological Database and Analysis Platform and the SwissTargetPredicating tool, and
182 insomnia target proteins were predicted by the DisGeNET and DrugBank databases. The
results of GO enrichment analysis showed that it included the reaction process of ammonium ion,
the regulation of the membrane potential and the secretion of catecholamine, while the results of
KEGG enrichment included the calcium signaling pathway, serotonin synapse, morphine addiction
and many more. Finally, using the Discovery Studio3.5 molecular docking verification software, it
was verified that the key target proteins are ADRB1 and HLA-DRB1.

Conclusion:

The components in the lavender essential oil include the Ethyl 2-(5-methyl-5-vinyltetrahydrofuran-
2-yl)propan-2-ylcarbonate (0.774); 5-Oxatricyclo[8.2.0.04,6]dodecane, 4,12,12-trimethyl-
9-methylene-, (1R,4R,6R,10S)-(0.147); P-Cymen-7-ol (0.063); .alpha-Humulenem (0.317);
Acetic acid, hexyl ester (1.374); etc. The role lavender plays in the treatment of insomnia might be
accomplished through the regulation of the key targets ADRB1 and HLA-DRB1.
Identification of Potential Biomarkers in Neonatal Sepsis by Establishing a Competitive Endogenous RNA Network
Authors: Liu Ling , Wang Hong , Zhang Xiaofei , Chen Rui
Published: April 2020

Background:

Neonatal sepsis is a serious and difficult-to-diagnose systemic infectious
disease occurring during the neonatal period.

Objective:

This study aimed to identify potential biomarkers of neonatal sepsis and explore its
underlying mechanisms.

Methods:

We downloaded the neonatal sepsis-related gene profile GSE25504 from the NCBI Gene
Expression Omnibus (GEO) database. The differentially expressed RNAs (DERs) were screened
and identified using LIMMA. Then, the functions of the DERs were evaluated using Gene
Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses.
Finally, a competing endogenous RNA (ceRNA) network was constructed and functional analyses
were performed.

Results:

The initial screening identified 444 differentially expressed (DE)-mRNAs and 45 DElncRNAs.
GO analysis showed that these DE-mRNAs were involved in immune response, defense
response, and positive regulation of immune system process. KEGG analysis showed that these
DE-mRNAs were enriched in 30 activated pathways and 6 suppressed pathways, and those with
the highest scores were the IL-17 signaling pathway and ribosome. Next, 722 miRNAs associated
with the identified lncRNAs were predicted using miRWalk. A ceRNA network was constructed
that included 6 lncRNAs, 11 mRNAs, and 55 miRNAs. In this network, HCP5, LINC00638, XIST
and TP53TG1 were hub nodes. Functional analysis of this network identified some essential immune
functions, hematopoietic functions, osteoclast differentiation, and primary immunodeficiency as
associated with neonatal sepsis.

Conclusion:

HCP5, LINC00638, TP53TG1, ST20-AS1, and SERPINB9P1 may be potential
biomarkers of neonatal sepsis and may be useful for rapid diagnosis; the biological process of the
immune response was related to neonatal sepsis.
Has the Time Come to Employ Population and Individual Bioequivalence for the Evaluation of Generics?
Authors: Micheal Francis , Sayana Mohanlal , Prasad Rajendra , Motilal Balamurali Musuvathi
Published: April 2020

Background:

Bioequivalence studies are a vital part of drug development. The average bioequivalence approach is the standard method of assessment to conclude whether the generic product is bioequivalent to the innovator product. Of late, debates are on whether the average bioequivalence approach adequately addresses drug interchangeability as it considers only population mean for the evaluation especially when highly variable drug products and narrow therapeutic index drugs are dealt with. Hence, the alternative approaches like population bioequivalence and individual bioequivalence assessment approaches emerge as they consider inter/intra-subject variance and subject- by-formulation variance along with population mean.

Objectives:

The objective of the study was to apply different bioequivalence assessment approaches in a replicate bioequivalence study to evaluate the drug interchangeability.

Methods:

This was an open-label, single-dose, randomized, balanced, two-treatment, three-period, three-sequence, partial replicate crossover bioequivalence study of omeprazole enteric-coated tablet 20 mg conducted on 48 normal healthy subjects under fed conditions. The plasma concentration of omeprazole was analyzed by a validated bioanalytical method to determine the pharmacokinetic and statistical parameters to assess average bioequivalence, population bioequivalence, and individual bioequivalence.

Results:

In this study, test formulation was shown to be bio-inequivalent to the reference formulation by average bioequivalence, population bioequivalence, and individual bioequivalence approaches.

Conclusion:

The outcome of the evaluation clearly states that the bioequivalence outcome of all these approaches are the same. Obviously, it does not mean that these three approaches provide the same outcome though the consideration of variances varies. Certainly, population bioequivalence and individual bioequivalence approach will be more accurate for the assessment of drug interchangeability.
ROLE-PLAYING MODEL: IS IT EFFECTIVE TO IMPROVE STUDENTS’ ACCOUNTING LEARNING MOTIVATION AND LEARNING ACHIEVEMENTS?
Authors: Saptono Laurentius , Soetjipto Budi Eko , Wahjoedi Wahjoedi , Wahyono Hari
Published: April 2020

Teachers need to organize learning that is contextual, innovative, and interesting so that students are more motivated to learn and they get better learning outcomes. The research was aimed to examine the effectiveness of role-playing model to improve the twelfth-grade social students’ learning motivation and their learning achievements on accounting subject with basic competence of practicing accounting cycles of service companies. The research was conducted with a quasi experiment for 3 public high schools in Sleman Regency. There were 206 total respondents for this research. Research data was gathered by using two methods: tests and questionnaires. Independent sample t-test was used for data analysis techniques. The result of this research showed that t-test for equality of mean of learning motivation was significant (sig. = .000 <  α = .05) and learning achievement was also significant (sig. = .000 <  α = .05). At the treatment class, students’ learning motivation was very high and their learning achievement was high. Thus, it was concluded that the role playing model was effective to improve the twelfth-grade social students’ learning motivation and their learning achievements on accounting subject with basic competence of practicing accounting cycles of service companies.
DOES THE NUMBER OF SUPERVISED COUNSELING PRACTICE EXPERIENCES MAKE DIFFERENCE IN THE WISDOM OF PRE-SERVICE COUNSELORS?
Authors: Taufiq Agus , Herdi Herdi
Published: April 2020

Wisdom is one of the fundamental qualities of personality, core competence, and predictors of effective counselor. The wisdom of a pre-service counselor is predicted to develop if the counselor has the opportunity to undergo, ask, reflect, and internalize his/her experiences through supervised counseling practice. The objective of the research is to compare the wisdom resulted by Indonesian pre-service counselors based on the number of supervision during counseling practices. The research used the ex post facto method. The sample of this research consisted of 489 sixth semester pre-service counselors of 11 guidance and counseling department in Indonesia, whereas 307 students only received < 3x supervision, and 182 students with >3x supervision. Data were collected using Indonesian Counselor's Wisdom Scale with Cronbach’s Alpha = .92. The t-test results show that there was a significant difference in the average score of wisdom and each dimension: religious, personal, social, emotional, reflective, and ethic of the pre-service counselors based on the number of supervised counseling practice where those with less supervision had better quality of wisdom. This means that the small number of supervised counseling practice experience but with a quality of supervisory working alliance can develop the wisdom of pre-service counselors.
EFFECT OF PHYSICAL CONDITIONING ON STUDENT BASIC SKILLS GYMNASTICS
Authors: Sukamti Endang Rini , Budiarti Ratna , Nurfadhila Risti
Published: April 2020

Physical conditioning was considered as a strong foundation for developing techniques from different fields. The aims of this study was to determine the impact of physical conditioning in parenting students or athletes gymnastic basic skills. The study was a surveyed research. The study sampling was 82 students aged between 18-19 years from Sport sciences, exactly coaching sciences. Data collection methods used checks and measurements of bio motor and gymnastic fundamental skills. Data analysis using correlation and linear regression to predict the future competence. The results showed that: there was significant correlation between the physical conditioning items and gymnastics basics skills, but there is also strong significant linear regression (p: .032<.05)  from physical conditioning with basic skill of Gymnastics. The standing balance (r = .728) and broad jump (r = .751) were found more influenced for gymnastic basic skills. There was a great significant different between the pre-test and posttest gymnastic basic skills means with p value < .001. The high standard deviation between the items showed the different adaptation of the subjects according to the physical conditioning. In conclusion physical conditioning was found as parenting for developing the gymnastic basic skills.
Pregão eletrônico: um estudo das causas de cancelamento de itens no âmbito de uma universidade federal
Authors: Neves Meryellem Yokoyama , Moré Rafael Pereira Ocampo
Published: April 2020

As instituições federais de ensino superior (Ifes), constituídas nas formas de fundações ou autarquias, por fazerem parte da administração pública, estão obrigadas a seguir as regras da licitação. Desse modo, a Universidade Federal de Santa Catarina (UFSC), por ser classificada como uma autarquia federal e estar sujeita às normas especificadas na Constituição Federal, deve adotar a licitação como meio para efetivação de suas compras. Esta pesquisa propõe analisar os cancelamentos de itens de material de consumo em pregões eletrônicos realizados no âmbito da Universidade Federal de Santa Catarina, no período de 2014 a 2018. A pesquisa, quanto aos fins, caracteriza-se como aplicada e descritiva. Quanto aos meios, foram utilizadas as pesquisas de campo, documental e bibliográfica. Dessa forma, considerando as informações identificadas a partir do cumprimento do objetivo, observa-se que a fase interna é de extrema importância para o sucesso da licitação, pois os principais motivos de cancelamento de itens, identificados neste estudo, estão relacionados diretamente à especificação do objeto e pesquisa de preços, os quais possuem relação direta com a fase preparatória do certame. Ações de aprimoramento para os processos de compras e licitações foram propostas; entre elas destaca-se a necessidade de maior conscientização e capacitação por parte dos servidores requerentes quanto às suas atribuições na fase interna do certame.
Serious Motion-Based Exercise Games for Older Adults: Evaluation of Usability, Performance, and Pain Mitigation
Authors: Brauner Philipp , Ziefle Martina
Published: April 2020

Background

Many societies are facing demographic changes that challenge the viability of health and welfare systems. Serious games for health care and ambient assisted living (AAL) offer health benefits and support for older adults and may mitigate some of the negative effects of the demographic shift.

Objective

This study aimed to examine the acceptance of serious games to promote physical health in AAL environments. Since AAL environments are designed specifically to support independent living in older adults, we studied the relationship among age and user diversity, performance in the game, and overall usability and acceptance evaluation.

Methods

We developed a motion-based serious exercise game for prototypical AAL environments. In two evaluations, outside (n=71) and within (n=64) the AAL environment, we investigated the influence of age, gender, self-efficacy in interacting with technology, need for achievement on performance, effect of the game, usability evaluation of the game, and overall acceptance.

Results

Both games were evaluated as easy to use and fun to play. Both game interventions had a strong pain-mitigating effect in older adults (game 1: −55%, P=.002; game 2: −66%, P=.01).

Conclusions

Serious exercise games outside and inside AAL environments can contribute to individuals’ health and well-being and to the stability of health care systems.
Efficacy of a Theory-Based Cognitive Behavioral Technique App-Based Intervention for Patients With Insomnia: Randomized Controlled Trial
Authors: Rajabi Majd Nilofar , Broström Anders , Ulander Martin , Lin Chung-Ying , Griffiths Mark D , Imani Vida , Ahorsu Daniel Kwasi , Ohayon Maurice M , Pakpour Amir H
Published: April 2020

Background

Sleep hygiene is important for maintaining good sleep and reducing insomnia.

Objective

This study examined the long-term efficacy of a theory-based app (including cognitive behavioral therapy [CBT], theory of planned behavior [TPB], health action process approach [HAPA], and control theory [CT]) on sleep hygiene among insomnia patients.

Methods

The study was a 2-arm single-blind parallel-group randomized controlled trial (RCT). Insomnia patients were randomly assigned to a treatment group that used an app for 6 weeks (ie, CBT for insomnia [CBT-I], n=156) or a control group that received only patient education (PE, n=156) through the app. Outcomes were assessed at baseline and 1 month, 3 months, and 6 months postintervention. Primary outcomes were sleep hygiene, insomnia, and sleep quality. Secondary outcomes included attitudes toward sleep hygiene behavior, perceived behavioral control, behavioral intention, action and coping planning, self-monitoring, behavioral automaticity, and anxiety and depression. Linear mixed models were used to evaluate the magnitude of changes in outcomes between the two groups and across time.

Results

Sleep hygiene was improved in the CBT-I group compared with the PE group (P=.02 at 1 month, P=.04 at 3 months, and P=.02 at 6 months) as were sleep quality and severity of insomnia. Mediation analyses suggested that perceived behavioral control on sleep hygiene as specified by TPB along with self-regulatory processes from HAPA and CT mediated the effect of the intervention on outcomes.

Conclusions

Health care providers might consider using a CBT-I app to improve sleep among insomnia patients.

Trial Registration

ClinicalTrials.gov NCT03605732; https://clinicaltrials.gov/ct2/show/NCT03605732
Efficacy and Safety of Rituximab in Refractory CIDP With or Without IgG4 Autoantibodies (RECIPE): Protocol for a Double-Blind, Randomized, Placebo-Controlled Clinical Trial
Authors: Shimizu Shinobu , Iijima Masahiro , Fukami Yuki , Tamura Natsuko , Nakatochi Masahiro , Ando Masahiko , Nishi Ryoji , Koike Haruki , Kaida Kenichi , Koga Michiaki , Kanda Takashi , Ogata Hidenori , Kira Jun-Ichi , Mori Masahiro , Kuwabara Satoshi , Katsuno Masahisa
Published: April 2020

Background

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an immune-mediated peripheral neuropathy that is currently classified into several clinical subtypes, which are presumed to have different pathogenic mechanisms. Recently, studies identified a subgroup of patients with CIDP who were positive for IgG4 autoantibodies against paranodal proteins, such as neurofascin-155 and contactin-1, who respond poorly to first-line therapies for typical CIDP, including intravenous immunoglobulin therapy.

Objective

This study aims to evaluate the efficacy and safety of intravenous rituximab according to IgG4 autoantibody status in patients with refractory CIDP.

Methods

The Evaluation of the Efficacy and Safety of Rituximab in Refractory CIDP Patients with IgG4 Autoantibodies in the Exploratory Clinical (RECIPE) trial consists of 2 cohorts: a multicenter, placebo-controlled, randomized study cohort of 15 patients with IgG4 autoantibody-positive CIDP (rituximab:placebo = 2:1) and an open-label trial cohort of 10 patients with antibody-negative CIDP. The primary endpoint is improvement in functional outcome assessed using the adjusted Inflammatory Neuropathy Cause and Treatment Disability Scale score at 26, 38, or 52 weeks after the start of treatment with rituximab in patients with CIDP and anti-paranodal protein antibodies. Secondary outcome measures include grip strength, manual muscle testing sum scores, results of nerve conduction studies, and other functional scales.

Results

We plan to enroll 25 cases for the full analysis set. Recruitment is ongoing, with 14 patients enrolled as of January 2020. Enrollment will close in September 2020, and the study is planned to end in December 2021.

Conclusions

This randomized controlled trial will determine if rituximab is safe and effective in patients with anti-paranodal antibodies. An open-label study will provide additional data on the effects of rituximab in patients with antibody-negative CIDP. The results of the RECIPE trial are expected to provide evidence for the positioning of rituximab as a pathogenesis-based therapeutic for refractory CIDP.

Trial Registration

ClinicalTrials.gov NCT03864185, https://clinicaltrials.gov/ct2/show/NCT03864185 ; The Japan Registry of Clinical Trials jRCT2041180037, https://jrct.niph.go.jp/en-latest-detail/jRCT2041180037

International Registered Report Identifier (IRRID)

DERR1-10.2196/17117
Physician Anxiety and Burnout: Symptom Correlates and a Prospective Pilot Study of App-Delivered Mindfulness Training (Preprint)
Authors: Roy Alexandra , Druker Susan , Hoge Elizabeth A , Brewer Judson A
Published: April 2020

BACKGROUND

Physician burnout is on the rise, yet little is known about its relationship to anxiety. Mindfulness-based stress reduction has demonstrated decreases in anxiety, yet physicians have reported reluctance to engage in it due to significant time commitments.

OBJECTIVE

The aims of this study are to assess whether app-based mindfulness training can reduce anxiety in physicians and to explore if anxiety and burnout are correlated, thus leading to a reduction in both anxiety and burnout.

METHODS

This was a nonrandomized pilot study comprised of 34 physicians who worked in a large US health care network and reported having anxiety. The intervention was an app-based mindfulness program. The main outcome measure was anxiety, measured by the Generalized Anxiety Disorder-7 (GAD-7). The secondary outcome measures assessed burnout: cynicism and emotional exhaustion items from the Maslach Burnout Inventory.

RESULTS

GAD-7 scores decreased significantly at posttreatment (1 month after treatment initiation, 48% reduction, P<.001) and at the 3-month follow-up (57% reduction, P<.001). There was a significant correlation between anxiety and burnout (cynicism: r=.43; P=.01; emotional exhaustion: r=.71; P<.001). There was also a significant decrease in cynicism (50% reduction, P=.003 at posttreatment; 50% reduction, P=.009 at follow-up) and emotional exhaustion at both time points (20% reduction, P<.001 at posttreatment; 20% reduction, P=.003 at follow-up).

CONCLUSIONS

This pilot study is the first to test an app-based mindfulness training program targeted at reducing anxiety with physicians and to demonstrate that in physicians, anxiety is correlated with burnout. These findings suggest that this may be an effective tool to reduce anxiety and burnout in physicians.

CLINICALTRIAL

ClinicalTrials.gov NCT04137081; https://www.clinicaltrials.gov/ct2/show/NCT04137081
Behavioral Health Professionals’ Perceptions on Patient-Controlled Granular Information Sharing (Part 2): Focus Group Study (Preprint)
Authors: Ivanova Julia , Tang Tianyu , Idouraine Nassim , Murcko Anita , Whitfield Mary Jo , Dye Christy , Chern Darwyn , Grando Adela
Published: April 2020

BACKGROUND

Patient-directed selection and sharing of health information “granules” is known as granular information sharing. In a previous study, patients with behavioral health conditions categorized their own health information into sensitive categories (eg, mental health) and chose the health professionals (eg, pharmacists) who should have access to those records. Little is known about behavioral health professionals’ perspectives of patient-controlled granular information sharing (PC-GIS).

OBJECTIVE

This study aimed to assess behavioral health professionals’ (1) understanding of and opinions about PC-GIS; (2) accuracy in assessing redacted medical information; (3) reactions to patient rationale for health data categorization, assignment of sensitivity, and sharing choices; and (4) recommendations to improve PC-GIS.

METHODS

Four 2-hour focus groups and pre- and postsurveys were conducted at 2 facilities. During the focus groups, outcomes from a previous study on patients’ choices for medical record sharing were discussed. Thematic analysis was applied to focus group transcripts to address study objectives.

RESULTS

A total of 28 health professionals were recruited. Over half (14/25, 56%) were unaware or provided incorrect definitions of granular information sharing. After PC-GIS was explained, all professionals demonstrated understanding of the terminology and process. Most (26/32 codes, 81%) recognized that key medical data had been redacted from the study case. A majority (41/62 codes, 66%) found the patient rationale for categorization and data sharing choices to be unclear. Finally, education and other approaches to inform and engage patients in granular information sharing were recommended.

CONCLUSIONS

This study provides detailed insights from behavioral health professionals on granular information sharing. Outcomes will inform the development, deployment, and evaluation of an electronic consent tool for granular health data sharing.

CLINICALTRIAL
Research on Information Sensing for Measuring Endometrial Cancer by Magnetic Resonance Imaging (Preprint)
Authors: Tao Jingxiong , Wang Yi , Liang Yi , Zhang Aohua , Borne Morisos
Published: April 2020

UNSTRUCTURED

This paper explores the 3.0T magnetic resonance (MRI) image for measuring the characteristics of endometrial cancer, and evaluates the value of MRI plain scan plus enhanced combined diffusion-weighted imaging (DWI) in preoperative staging information sensing of endometrial cancer. The paper retrospectively analyzed the clinical data of 202 patients with endometrial cancer who were admitted to the gynecology department of our hospital from January 2014 to August 2018. All patients in this group underwent MRI. The study found that 202 patients with endometrial cancer were confirmed by surgical pathology: 131 patients in stage IA, 28 patients in stage IB, 15 patients in stage II, 3 patients in stage IIIA, 16 patients in stage IIIB, 4 patients in stage IIIC1, 1 patient in stage IIIC2, and IVA stage There were 1 case and 3 cases in IVB stage. Therefore, it can be concluded that, in endometrial cancer, the coincidence rate between 3.0TMRI preoperative staging and postoperative pathological staging is high, and it can be used as a routine examination before endometrial cancer patients, thus providing objective basis for clinical decision-making.
Effect of saline irrigation method on the growth of rice (Oryza sativa L.)
Authors: Adlian Adlian , Kurniasih Budiastuti , Indradewa Didik
Published: April 2020

A field experiment was carried out to study rice growth under salinity stress in permanently flooded, intermittent, and saturated soil conditions. The experiment was conducted at field station of Faculty of Agriculture, Universitas Gadjah Mada located in Bantengan village, Banguntapan, Bantul, DIY, from August to November 2015. The treatments were arranged in a split-plot randomized complete block design, consisting of three irrigation methods as the main plot and two levels of salinity as the subplot, thereby resulting in six treatment combinations with three replications within each combination treatment. The three irrigation methods were permanent irrigation (flooded soil), intermittent irrigation (wet/dry soil), and irrigation above field capacity (saturated soil). The two levels of salinity were fresh water as control treatment (EC  0.3 dS.m-1) and saline water (EC  5 dS.m-1). The results of the experiment showed that there was no significant interaction effect of irrigation method and salinity on all observed rice growth variables. Salt stress negatively affected the rice growth, including plant height, plant dry weight, leaf area, and leaf area ratio (LAR). Irrigation method significantly affected plant dry weight and number of tillers at 3 and 9 weeks after planting. Permanent irrigation resulted in the highest plant growth compared to intermittent irrigation and above field capacity condition.
Review: Challenges and opportunities of implementing mass productivity scale (MPS) at date farms in Malaysia
Authors: Haris Asmaddy , Kamarubahrin Aimi Fadzirul , Mohd Daud Siti Nurazira , Kefeli @ Zulkefli Zurina , Ahmad Nursilah , Muhamed Nurul Aini , Abdul Shukor Syadiyah
Published: April 2020

The study aimed to review the challenges and opportunities of mass productivity scale (MPS) for the dates (Phoenix dactylifera L.) farm in Malaysia. The review on site and document was done to drill the issues faced by dates palm farmers. The common issues affecting dates farm in Malaysia are insect pest attack, import permit, lack of expertise, and climate and soil requirements. In a united response, the government should form the National Dates Palm Centre (NDPC) which will explore opportunities to address issues faced by the dates palm sector in Malaysia.
Inherited Tubulopathies of the Kidney
Authors: Downie Mallory L. , Lopez Garcia Sergio C. , Kleta Robert , Bockenhauer Detlef
Published: April 2020

The kidney tubules provide homeostasis by maintaining the external milieu that is critical for proper cellular function. Without homeostasis, there would be no heartbeat, no muscle movement, no thought, sensation, or emotion. The task is achieved by an orchestra of proteins, directly or indirectly involved in the tubular transport of water and solutes. Inherited tubulopathies are characterized by impaired function of one or more of these specific transport molecules. The clinical consequences can range from isolated alterations in the concentration of specific solutes in blood or urine to serious and life-threatening disorders of homeostasis. In this review, we focus on genetic aspects of the tubulopathies and how genetic investigations and kidney physiology have crossfertilized each other and facilitated the identification of these disorders and their molecular basis. In turn, clinical investigations of genetically defined patients have shaped our understanding of kidney physiology.
PRACTICES AND PERCEPTION OF NIGERIAN COMMUNITY PHARMACISTS TOWARDS ANTIMICROBIAL STEWARDSHIP PROGRAM
Authors: ABUBAKAR USMAN
Published: April 2020

Objective: Community pharmacists have an important role in promoting the appropriate use of antibiotics. There is a paucity of data describing the contributions of community pharmacists in antimicrobial stewardship program (ASP) in Nigeria. This study evaluated the practices and perceptions of community pharmacists towards ASP.

Methods: This was a cross-sectional study conducted among community pharmacists in two cities in Northern Nigeria: Minna and Kaduna, using a 30-item validated and pre-tested questionnaire. Data collected between April and May 2019 and analyzed using SPSS version 23.

Results: Of 130 community pharmacists, 98 completed and returned the questionnaire (response rate: 75.3%). More than 90% strongly agreed/agreed that ASP is important to reduce inappropriate use of antibiotics and antibiotic resistance, improve patient’s clinical outcomes. However, lack of training (56.1%), lack of cooperation from physicians (61.2%) and lack of access to patient records (66.8%) were identified as barriers to community pharmacists’ involvement in ASP. Overall, community pharmacists had good practices (median score: 3.5; IQR: 1–5) and positive perceptions (median score: 4.0; IQR: 3–5) towards ASP. Job status and dispensing antibiotics without prescription were significantly associated with practice, while age and job status were associated with perception towards ASP.

Conclusion: Community pharmacists demonstrated good practices and positive perceptions towards ASP. However, lack of training and lack of cooperation from prescribers limit their involvement in the program. Training of community pharmacists in antimicrobial stewardship and inter-professional collaboration are recommended.
DEVELOPMENT AND VALIDATION OF A SIMPLE HPLC METHOD FOR ESTIMATION OF MYCOPHENOLATE MOFETIL IN MICROEMULSION FORMULATION
Authors: KAUR PALAKDEEP , KUMAR MOHIT , MANDAL UTTAM KUMAR
Published: April 2020

Objective: The present study deals with the development, validation and application of a simple, precise and accurate HPLC method for the determination of mycophenolate mofetil in pharmaceutical formulations and microemulsions.

Methods: In this method, a simple isocratic mobile phase composition of methanol and water (75:25 v/v) pumped at 1 ml/minute flow rate through Phenomenex C18 column (dimension: 250 4.6 mm and 5 µm particle size) was used. Injection volume was 20 µl and analysis of mycophenolate mofetil was carried out at 250 nm.

Results: The coefficient of regression was found to be 0.9996, indicating the linearity of the developed method within a range of 0.1 to 10 µg/ml. The limit of detection (LOD) and the limit of quantization (LOQ) were found to be 3.660ng/ml and 11.091ng/ml, respectively. The results showed that % deviation for change in compositions of the mobile phase, flow rate and temperature was within a range of-5.51 to 10.99%,-3.70 to 8.80% and-5.29 to 10.90%, respectively. The method seemed sensitive to change of temperature (±5 ○C) and methanol composition (±2%) as the results were at the boundary limit of 10% deviation.

Conclusion: A simple, precise and accurate HPLC method for the determination of drug content from microemulsion has been developed and validated in accordance with ICH guidelines.
O protagonismo e a autonomia das crianças nas séries de TV
Authors: Debus Jose Carlos dos santos
Published: April 2020

Este texto compõe um estudo maior sobre o conceito de autonomia nas relações de ensino e aprendizagem desde uma investigação entre crianças que frequentavam o 7º ano do ensino fundamental de uma escola pública. O objetivo da pesquisa foi o de entender o conceito de autonomia a partir do olhar da criança e também compreender como este conceito dialoga com outros conceitos que compõem o mesmo campo semântico, tais como protagonismo e independência. Seguimos o caminho da pesquisa qualitativa de recepção, com o uso de questionários estruturados e dos diálogos dentro do grupo. Nosso referencial teórico segue os estudos de Stuart Hall, de Jesús Martín-Barbero e de Guillermo Orozco Gómez. Vimos que a escola deve pluralizar novos alfabetos e novas leituras. Este entendimento se faz necessário quando a informação que dá acesso ao saber passa de uma forma ou de outra pelas diversas redes e tramas das imagens e das escrituras eletrônicas.
Prática social educativa em Zilda Arns: pela memória, contra o esquecimento
Authors: Otto Claricia , Rodrigues Fabiano Batista
Published: April 2020

Neste artigo, revisitamos memórias da médica pediatra Zilda Arns Neumann (1934-2010), fundadora e coordenadora da Pastoral da Criança até 2010, presentes em quatro documentos: duas entrevistas, uma concedida em 1998 e outra em 2003 e os textos Pastoral da Criança: uma experiência consagrada (2000), e Zilda Arns Neumann: ela criou uma rede de solidariedade que salva centenas de milhares de crianças brasileiras (2003). Na esteira das análises de Walter Benjamin — da vida moderna condenada a “não deixar rastros”; da exigência da memória e ao mesmo tempo sobre as dificuldades de narração da experiência comum, da transmissão e do lembrar — objetivamos rememorar aspectos da ação educativa de Zilda Arns não como comemoração e/ou formas de apologia, mas como uma reflexão sobre as incompletudes e esquecimentos no tempo presente. A reminiscência sobre a mobilização e adesão de milhares de voluntários à Pastoral da Criança leva a concluir que ela somente foi possível porque Zilda Arns construiu um método de justificativa dessa Pastoral estreitamente vinculado a uma mística que unia fé e ação por melhores condições de vida. Pelo caminho de uma metodologia de trabalho comunitário compreendido e assumido como missão, promoveu uma mobilização popular em torno de um objetivo comum: do compromisso com a justiça para a superação da exclusão social.
Cultura digital: tecnologias, escola e novas práticas educativas
Authors: Tamanini Paulo Augusto , Tavares Santos Jean Mac Colle , Souza Maria do Socorro
Published: April 2020

Este estudo, de cunho bibliográfico, discute a inserção das tecnologias digitais na educação no contexto da cultura digital e as novas demandas teórico-metodológicas por ela exigidas, a fim de desenvolver a criticidade no uso das tecnologias, seja ao consumir, circular ou produzir conteúdo, visando à formação cidadã do aluno. Sob a perspectiva teórica dos Estudos Culturais, o texto aborda a cultura digital, seu conceito e características, a partir das mudanças culturais ocorridas nos últimos tempos, causadas pela revolução tecnológica e a consequente centralidade da cultura nesse contexto. Autores como Hall (1997), Heinsfeld e Pischetola (2017), Bortolazzo (2016), Lévy (1996, 1999), Arruda (2013, 2014) e Lemos (2003, 2008, 2009) serviram de referencial teórico para o debate. Pode-se concluir que a adequação da escola à cultura digital abrange bem mais do que a mera inserção dos artefatos digitais na prática pedagógica, exigindo profundas mudanças nos modelos pedagógicos vigentes
Formação continuada de professores: perspectivas e contradições epistemológicas recorrentes na elaboração de documentos oficiais da educação
Authors: Aparecida Gislaine de Matos , Selma Maria Grosch , Farias Jaime Dresch
Published: April 2020

A formação continuada de professoras, de 4º e 5º ano do Ensino Fundamental, é a temática deste artigo que foi produzido a partir da pesquisa realizada no Mestrado em Educação, na UNIPLAC, e tem como objetivo discutir o processo da formação continuada a partir das concepções teóricas constantes nos documentos oficiais que regem a educação. Desta forma, apresenta os resultados obtidos a partir da pesquisa documental sobre os registros oficiais que orientam a educação no município de Lages/SC. Buscamos conhecer a Proposta Curricular Municipal o Plano Municipal de Educação de Lages/SC (2015), e o Projeto conhecer: a excelência do ser na busca do saber e do fazer (2012). Os resultados da pesquisa apresentam algumas contradições de base conceitual, principalmente no que concerne à defesa de uma perspectiva histórico social com base no materialismo histórico dialético, e ao mesmo tempo tem como base os 4 pilares da Educação de Jaques Delors.
The low level of biology teacher candidate questioning skills
Authors: Darmadi D. , Putra Riki Apriyandi
Published: April 2020

Questioning skills is one of competencies required by teachers in dealing with the 21st-Century challenges. The purpose of this study was profiling biology teacher candidates’ questioning skills in Pekanbaru. The subjects of the research were the students, in three institutions, who were taking Zoology course. The total number of the subjects were 278 students selected using purposive random sampling. The instrument used was test contained of five items which instructed students to make questions related to five objects. The results showed that the teacher candidates’ question level in three institution were low-level question (more than 50% in C1-C3 level). The questions posed were dominance in the level of memorizing, understanding, applying, and analyzing. They were not accustomed to asking questions with the evaluating and creating levels. The systematic of question was dominated as a divergent question, while the question area asked was dominated in the physiology (32.93%) and morphology (32.14%) concept. The information gained from this study can be consideration point for further research.
Plastic relief sculpture: Improving Nigerian students’ performance in practical biology
Authors: Odewumi Michael Olubunmi , Akintola David Akinjide , Bello Isyaka
Published: April 2020

Among the factors identified to be responsible for the poor performance of senior high school students in biology is inappropriate instructional media. This study investigated the effects of plastic relief sculpture on senior high school students’ performance in biology practical activity in Ogbomoso, South Local Government Area of Oyo State, Nigeria. Moreover, it also observed gender as the moderating effect in this study. The population of this quasi-experimental study was the all senior high school biology students in Oyo State. Two intact classes of 120 biology students were randomly sampled for the study. Two instruments were used in this study i.e. Students’ Biology Practical Test and Biology Practical Lesson Notes. The findings of this study revealed that there was significant difference existed between the performance of students in the experimental and control group (F (8, 51) = 1.89, p < 0.05). Meanwhile, female students performed insignificantly different compared with male students (t (118) = 7.16, p = 0.12). Therefore, the study concluded that plastic instructional relief sculpture is effective in improving students’ performance in biology. Thus, it is recommended that teachers should adopt plastic relief sculpture as the innovative instructional resource in teaching biology.
Students’ science process skills and interpersonal intelligence in biology learning using guided inquiry
Authors: Nopiya N. , Hindriana Anna Fitri , Sulistyono S.
Published: April 2020

Teacher-centered learning has no ability in empowering students’ science process skills and interpersonal intelligence. This study aimed at analyzing the effect of guided inquiry on students’ Science Process Skills (SPS) and Interpersonal Intelligence (II). This quasi-experiment used nonequivalent control group design. This study involved control and experimental classes of eleventh graders in biology class in which the material learnt was respiratory system. The SPS data was collected using test instrument, whereas the II data was gained using observation sheet. The analysis results informed that the students who joint the guided inquiry class possessed the better competencies, both in their SPS (p = 0.04) and II (p = 0.001). Therefore, the guided inquiry significantly contributes toward the improvement of students’ SPS and II. The findings of this research can be the considerable information to creat the learning which acommodates students’ SPS and II.
The critical thinking skills of biology teacher candidates toward the ethical issues
Authors: Maryuningsih Yuyun , Hidayat Topik , Riandi R. , Rustaman Nuryani Y.
Published: April 2020

The critical thinking skills are needed by biology teacher candidates to deal with the nowadays ethical issues arisen among society. The aim of this research was to observe the critical thinking skills of biology teacher candidates toward the ethical issues especially in genetic field through online discussion. The subjects of this experimental research were 104 biology teacher candidates who took the Genetics Course in an institution in West Java.  The subject were devided into three groups consisted of two experimental groups and one control group which conducted online discussion by using Gen-21cs application. The experimental groups discussed the topics given by the both instructor and students, while the control group only discussed the topics given by the instructor. The topics discussed were cell cloning, Genetically Engineered Products, stemcell and inbreeding. The online discussions have been done for four weeks. The biology teacher candidate responses were measured using the critica thinking measurement developed by Facione.The critical thinking scores gained were analyzed using descriptive statistic in term of mean. The results showed that the critical thinking skills of the biology teacher candidates tended to increase in each discussion sessions. Online discussion can be used to ensure the other thinking skills.
Metacognitive awareness of commuter and resident students of Islamic high school in biology learning
Authors: Sari Afifah Putri , Karyanto Puguh , Ashadi A.
Published: April 2020

There have been several studies which focus on metacognitive awareness of senior high school students done. However, the factors influence metacognitive awareness have not been widely revealed. Thus, this research aimed at distinguishing the metacognitive awareness between the commuter and resident students’ of Islamic High School in biology learning. The subject of this quantitative research was divided into two groups (commuter and resident students). The sample unit in this study consisted of three boarding schools i.e. Al-Abidin Bilingual Resident School, Al-Islam 1 Senior High School, and Majelis Taqlim Al-Quran Senior High School that were selected by purposive sampling. The participants in this study were 88 students of grade X (40 commuters and 48 residents) which were taught in the same class. The data were collected using the survey method. Metacognitive Awareness Inventory (MAI) was used to obtain the data of the students’ metacognitive awareness. The data were analyzed using independent samples t-test. The results indicated that there was a significant difference between commuter and resident students’ metacognitive awareness (p = 0.027). In addition, the commuter students performed better metacognitive awareness on biology learning than resident students.