bluuebunny/crossref_metadata_2025 huggingface dataset:
Opening-Wedge Distal Femoral Osteotomy With Concomitant Medial Meniscal Root Repair
Authors: Braaten Jacob A. , Banovetz Mark T. , Homan Morgan D. , Monson Jill K. , Kennedy Nicholas I. , LaPrade Robert F.
Published: May 2023

Background:

Valgus malalignment leads to excessive loading of the lateral compartment and has been associated with lateral compartment meniscal injuries and early-onset knee osteoarthritis. Distal femoral osteotomy (DFO) is a treatment option that allows correction of the mechanical access to offload the lateral compartment. Lateral opening-wedge distal femoral osteotomy and medial meniscal root repairs are both aimed to address the pathologic biomechanics of the tibiofemoral joint and when successful can delay or even prevent progression to end-stage osteoarthritic changes in the lateral and medial compartment, respectively.

Indications:

Distal femoral osteotomy is indicated for patients with normal metabolic bone health and valgus malalignment who may present with concurrent lateral meniscal injury, symptomatic lateral compartment arthritis, or a chronic medial collateral ligament tear/laxity.

Technique Description:

Long-leg alignment radiographs and preoperative magnetic resonance images are required to evaluate the degree of mechanical access deviation and to evaluate for soft tissue injury, as there is often concomitant lateral meniscal or cartilage pathology present. This technique demonstrates the optimal order of surgical steps for DFO with a concurrent medial meniscal root repair. The senior author’s preferred order is to first perform the open lateral approach and expose the lateral cortex for the placement of plate prior to arthroscopic work and excess fluid extravasation. Intra-articular work is then performed with a diagnostic arthroscopy followed by medial meniscal root repair. Finally, the osteotomy and subsequent internal fixation are performed.

Results:

The literature on opening-wedge DFO outcomes is heterogeneous, with variable rates of successful outcomes and complications. Saithna et al reported that International Knee Documentation Committee and the pain subdomain of Knee injury and Osteoarthritis Outcome Scores significantly improved postoperatively following lateral opening-wedge DFOs in patients with lateral compartment osteoarthritis. The 10-year success rate of varus-producing DFO has been reported to be 64% to 85%.

Discussion:

We describe a technique for correction of a valgus deformity with opening-wedge DFO and concurrent meniscal root repair. This surgical technique effectively restores the native femoral and tibial axis with appropriate load distribution and also concurrently restores the appropriate function of the medial meniscus which allows axial force dispersion via hoop stresses for the medial compartment.

Patient Consent Disclosure Statement:

The author(s) attests that consent has been obtained from any patient(s) appearing in this publication. If the individual may be identifiable, the author(s) has included a statement of release or other written form of approval from the patient(s) with this submission for publication.
Personalising airway clearance in chronic suppurative lung diseases: a scoping review
Authors: Schofield Lynne M. , Singh Sally J. , Yousaf Zarah , Wild Jim M , Hind Daniel
Published: May 2023

Background

Personalised airway clearance techniques are commonly recommended to augment mucus clearance in chronic suppurative lung diseases. It is unclear what current literature tells us about how airway clearance regimens should be personalised. This scoping review explores current research on airway clearance technique in chronic suppurative lung diseases, to establish the extent and type of guidance in this area, identify knowledge gaps and determine the factors which physiotherapists should consider when personalising airway clearance regimens.

Methods

Systematic searching of online databases (MEDLINE, EMBASE, CINAHL, PEDro, Cochrane, Web of Science) was used to identify full-text publications in the last 25 years that described methods of personalising airway clearance techniques in chronic suppurative lung diseases. Items from the TIDieR framework provideda prioricategories which were modified based on the initial data to develop a “Best-fit” framework for data charting. The findings were subsequently transformed into a personalisation model.

Results

A broad range of publications were identified, most commonly general review papers (44%). The items identified were grouped into seven personalisation factors: physical, psychosocial, airway clearance technique (ACT) type, procedures, dosage, response and provider. As only two divergent models of ACT personalisation were found, the personalisation factors identified were then used to develop a model for physiotherapists.

Conclusions

The personalisation of airway clearance regimens is widely discussed in the current literature, which provides a range of factors that should be considered. This review summarises the current literature, organising findings into a proposed airway clearance personalisation model, to provide clarity in this field.
Exploring computer-based imaging analysis in interstitial lung disease: opportunities and challenges
Authors: Felder Federico N. , Walsh Simon L.F.
Published: May 2023

The advent of quantitative computed tomography (QCT) and artificial intelligence (AI) using high-resolution computed tomography data has revolutionised the way interstitial diseases are studied. These quantitative methods provide more accurate and precise results compared to prior semiquantitative methods, which were limited by human error such as interobserver disagreement or low reproducibility. The integration of QCT and AI and the development of digital biomarkers has facilitated not only diagnosis but also prognostication and prediction of disease behaviour, not just in idiopathic pulmonary fibrosis in which they were initially studied, but also in other fibrotic lung diseases. These tools provide reproducible, objective prognostic information which may facilitate clinical decision-making. However, despite the benefits of QCT and AI, there are still obstacles that need to be addressed. Important issues include optimal data management, data sharing and maintenance of data privacy. In addition, the development of explainable AI will be essential to develop trust within the medical community and facilitate implementation in routine clinical practice.
Effects of pre-operative biopsy on recurrence and survival in stage I lung adenocarcinoma patients in China
Authors: Zhang Yuan , Hu Yi , Zhang Shu , Zhu Min , Lu Jun , Hu Bin , Guo Xiaojuan , Zhang Yuhui
Published: May 2023

Background

Whether pre-operative biopsy affects post-operative recurrence and metastasis of lung cancer patients is still controversial.

Methods

In order to clarify these disputes, we collected relevant literature to conduct a meta-analysis. To validate the results of the meta-analysis, we retrospectively analysed 575 patients with stage I lung adenocarcinoma who underwent surgical resection at our centre from 2010 to 2018 using propensity score matching and competing risk models.

Results

5509 lung cancer patients from 11 articles were included in the meta-analysis. Summary analysis showed that the total recurrence rate of the biopsy group was higher than that of the nonbiopsy group (risk ratio 1.690, 95% CI 1.220–2.330; p=0.001). After propensity score matching, we found that there was no significant correlation between biopsy and total recurrence (risk ratio 1.070, 95% CI 0.540–2.120; p=0.850). In our cohort, of 575 stage I lung adenocarcinomas, 113 (19.7%) patients underwent pre-operative biopsy. During a median (interquartile range) follow-up of 71 (57–93) months, multivariable analyses showed pre-operative biopsy in the overall observation cohort (subdistribution hazard ratio (SHR) 1.522, 95% CI 0.997–2.320; p=0.051) and in the propensity score-matched cohort (SHR 1.134, 95% CI 0.709–1.810; p=0.600) was not significantly correlated with the risk of recurrence and metastasis. Moreover, the pre-operative biopsy did not affect disease-free survival (SHR 0.853, 95% CI 0.572–1.273; p=0.438) or overall survival (SHR 0.647, 95% CI 0.352–1.189; p=0.161).

Conclusion

Pre-operative biopsy might not increase the risk of recurrence and metastasis, suggesting that these procedures might be safe for patients with stage I lung adenocarcinoma whose diagnosis is difficult to determine before surgery.
Pre- and post-vaccination characteristics and risk factors for COVID-19 outcomes in a Swedish population-based cohort of COPD patients
Authors: Kirui Brian K. , Santosa Ailiana , Vanfleteren Lowie E.G.W. , Li Huiqi , Franzén Stefan , Stridsman Caroline , Nyberg Fredrik
Published: May 2023

Rationale

Evidence on risk factors for Coronavirus disease 2019 (COVID-19) outcomes among patients with COPD in relation to COVID-19 vaccination remains limited. The objectives of the present study were to characterise determinants of COVID-19 infection, hospitalisation, intensive care unit (ICU) admission and death in COPD patients in their unvaccinated state compared to when vaccinated.

Methods

We included all COPD patients in the Swedish National Airway Register (SNAR). Events of COVID-19 infection (test and/or healthcare encounter), hospitalisation, ICU admission and death were identified from 1 January 2020 to 30 November 2021. Using adjusted Cox regression, associations between baseline sociodemographics, comorbidities, treatments, clinical measurements and COVID-19 outcomes, during unvaccinated and vaccinated follow-up time, were analysed.

Results

The population-based COPD cohort included 87 472 patients, among whom 6771 (7.7%) COVID-19 infections, 2897 (3.3%) hospitalisations, 233 (0.3%) ICU admissions and 882 (1.0%) COVID-19 deaths occurred. During unvaccinated follow-up, risk of COVID-19 hospitalisation and death increased with age, male sex, lower education, non-married status and being foreign-born. Comorbidities increased risk of several outcomes,e.g.respiratory failure for infection and hospitalisation (adjusted hazard ratios (HR) 1.78, 95% CI 1.58–2.02 and 2.51, 2.16–2.91, respectively), obesity for ICU admission (3.52, 2.29–5.40) and cardiovascular disease for mortality (2.80, 2.16–3.64). Inhaled COPD therapy was associated with infection, hospitalisation and death. COPD severity was also associated with COVID-19, especially hospitalisation and death. Although the risk factor panorama was similar, COVID-19 vaccination attenuated HRs for some risk factors.

Conclusion

This study provides population-based evidence on predictive risk factors for COVID-19 outcomes and highlights the positive implications of COVID-19 vaccination for COPD patients.
A new profiling approach for DNA sequences based on the nucleotides' physicochemical features for accurate analysis of SARS-CoV-2 genomes
Authors: Akbari Rokn Abadi Saeedeh , Mohammadi Amirhossein , Koohi Somayyeh
Published: May 2023

Background

The prevalence of the COVID-19 disease in recent years and its widespread impact on mortality, as well as various aspects of life around the world, has made it important to study this disease and its viral cause. However, very long sequences of this virus increase the processing time, complexity of calculation, and memory consumption required by the available tools to compare and analyze the sequences.

Results

We present a new encoding method, named PC-mer, based on the k-mer and physic-chemical properties of nucleotides. This method minimizes the size of encoded data by around 2 k times compared to the classical k-mer based profiling method. Moreover, using PC-mer, we designed two tools: 1) a machine-learning-based classification tool for coronavirus family members with the ability to recive input sequences from the NCBI database, and 2) an alignment-free computational comparison tool for calculating dissimilarity scores between coronaviruses at the genus and species levels.

Conclusions

PC-mer achieves 100% accuracy despite the use of very simple classification algorithms based on Machine Learning. Assuming dynamic programming-based pairwise alignment as the ground truth approach, we achieved a degree of convergence of more than 98% for coronavirus genus-level sequences and 93% for SARS-CoV-2 sequences using PC-mer in the alignment-free classification method. This outperformance of PC-mer suggests that it can serve as a replacement for alignment-based approaches in certain sequence analysis applications that rely on similarity/dissimilarity scores, such as searching sequences, comparing sequences, and certain types of phylogenetic analysis methods that are based on sequence comparison.
Comparative study on left-sided versus right-sided hepatectomy for resectable peri-hilar cholangiocarcinoma: a systematic review and meta-analysis
Authors: Xu Bowen , Zhao Wei , Chang Jianhua , Yin Jinghua , Wang Nan , Dong Zhaoru , Zhi Xuting , Li Tao , Chen Zhiqiang
Published: May 2023

Background

Peri-hilar cholangiocarcinoma (pCCA) is a unique entity, and radical surgery provides the only chance for cure and long-term survival. But it is still under debate which surgical strategy (i.e., left-sided hepatectomy, LH or right-sided hepatectomy, RH) should be followed and benefitted.

Methods

We performed a systematic review and meta-analysis to analyze the clinical outcomes and prognostic value of LH versus RH for resectable pCCA. This study followed the PRISMA and AMSTAR guidelines.

Results

A total of 14 cohort studies include 1072 patients in the meta-analysis. The results showed no statistical difference between the two groups in terms of overall survival (OS) and disease-free survival (DFS). But compared to the LH group, the RH group exhibited more employment of preoperative portal vein embolization (PVE), higher rate of overall complications, post-hepatectomy liver failure (PHLF), and perioperative mortality, while LH was associated with higher frequency of arterial resection/reconstruction, longer operative time, and more postoperative bile leakage. There was no statistical difference between the two groups in terms of preoperative biliary drainage, R0 resection rate, portal vein resection, intraoperative bleeding, and intraoperative blood transfusion rate.

Conclusions

According to our meta-analyses, LH and RH have comparable oncological effects on curative resection for pCCA patients. Although LH is not inferior to RH in DFS and OS, it requires more arterial reconstruction which is technically demanding and should be performed by experienced surgeons in high-volume centers. Selectin of surgical strategy between LH and RH should be based on not only tumor location (Bismuth classification) but also vascular involvement and future liver remnant (FLR).
Intestinal endothelial cells increase HIV infection and latency in resting and activated CD4 + T cells, particularly affecting CCR6 + CD4 + T cells
Authors: Eddy Jessica , Pham Fisher , Chee Rachel , Park Esther , Dapprich Nathan , DeRuiter Stacy L. , Shen Anding
Published: May 2023

Background

With suppressive antiretroviral therapy, HIV infection is well-managed in most patients. However, eradication and cure are still beyond reach due to latent viral reservoirs in CD4 + T cells, particularly in lymphoid tissue environments including the gut associated lymphatic tissues. In HIV patients, there is extensive depletion of T helper cells, particularly T helper 17 cells from the intestinal mucosal area, and the gut is one of the largest viral reservoir sites. Endothelial cells line lymphatic and blood vessels and were found to promote HIV infection and latency in previous studies. In this study, we examined endothelial cells specific to the gut mucosal area—intestinal endothelial cells—for their impact on HIV infection and latency in T helper cells.

Results

We found that intestinal endothelial cells dramatically increased productive and latent HIV infection in resting CD4 + T helper cells. In activated CD4 + T cells, endothelial cells enabled the formation of latent infection in addition to the increase of productive infection. Endothelial-cell-mediated HIV infection was more prominent in memory T cells than naïve T cells, and it involved the cytokine IL-6 but did not involve the co-stimulatory molecule CD2. The CCR6 + T helper 17 subpopulation was particularly susceptible to such endothelial-cell-promoted infection.

Conclusion

Endothelial cells, which are widely present in lymphoid tissues including the intestinal mucosal area and interact regularly with T cells physiologically, significantly increase HIV infection and latent reservoir formation in CD4 + T cells, particularly in CCR6 + T helper 17 cells. Our study highlighted the importance of endothelial cells and the lymphoid tissue environment in HIV pathology and persistence.
Oral nicotinamide mononucleotide (NMN) to treat chronic insomnia: protocol for the multicenter, randomized, double-blinded, placebo-controlled trial
Authors: Gao Xiangyang , Li Junhua , Xu Sanping , Li Xueying , Wang Xicheng , Li Yongli , Huang Yan , Liu Shaohui , Zeng Qiang
Published: May 2023

Background

The treatment of insomnia, which is the most common sleep disorder, includes drug and behavioral treatment, but each treatment measure has its limitations. So new treatment method needs to be taken to improve the treatment effect. MN supplementation is a potential promising new method for the treatment of insomnia, resulting in a rising need for methodological research towards verifying its efficacy.

Methods/design

We describe a proposal for a multicenter, patient-assessor-blinded, randomized controlled trial with two parallel arms. A total of 400 chronic insomnia patients will be allocated 1:1 to the intervention group (treatment with oral NMN 320 mg/day) or control group (treatment with oral placebo). All subjects are clinical chronic insomnia patients who meet all inclusion criteria. All subjects are treated by taking NMN or placebo.

The primary outcome is the score on the Pittsburgh Sleep Quality Index (PSQI). Secondary outcomes are the score on the Insomnia Severity Index (ISI) and Epworth Sleeping Scale (ESS), the total sleep time (TST), sleep efficiency (SE), sleep latency, and REM sleep latency to assess sleep quality changes.

Subjects are assessed at two time points: baseline and follow-up. The duration of the clinical trial is 60 days.

Discussion

This study will provide more evidence on the effects of NMN on improving sleep quality among patients with chronic insomnia. If proven effective, NMN supplement can be used as a new treatment for chronic insomnia in the future.

Trial registration

Chinese Clinical Trial Registry (chictr.org.cn) ChiCTR2200058001. Registered on 26 March 2022.
Gender-specific impacts of thigh skinfold thickness and grip strength for predicting osteoporosis in type 2 diabetes
Authors: Lu Chieh-Hua , Lee Chien-Hsing , Wu Li-Wei , Liao Chun-Cheng , Su Sheng-Chiang , Liu Jhih-Syuan , Li Peng-Fei , Huang Chia-Luen , Ho Li-Ju , Lin Chien-Ming , Lin Ming-Hsun , Chang Chun-Yung , Liu Yi-Chen , Lin Chih-Ping , Cheng An-Che , Kuo Feng-Chih
Published: May 2023

Background

Diabetes with co-existing bone fragility or osteoporosis is common in elderly patients, whereas is frequently underestimated.

Methods

We conducted dual-energy x-ray absorptiometry (DXA) with 7-site skinfold (SF) and dominant hand grip strength measurements among patients with type 2 diabetes (T2DM) to assess their gender-specific associations. A total of 103 patients with T2DM (60 females and 43 males), aged between 50 and 80 years (median 68.0 years) were enrolled and 45 non-DM females were also included to compare with T2DM females.

Results

Our results revealed osteoporosis was negatively correlated with grip strength in both genders, negatively correlated with lean mass solely in males and negatively correlated with fat mass (particular the gynoid fat mass and thigh SF thickness) in females. Via performing multivariable stepwise logistic regression, we identified grip strength in both genders and thigh SF thickness in females as predictors for osteoporosis. Receiver operating characteristic curve analysis further disclosed 20.5 mm female thigh skinfold thickness, 18.1 kg female grip strength and 29.0 kg male grip strength as reasonable cutoff levels for predicting osteoporosis in the Taiwanese patients with T2DM.

Conclusions

Patients with T2DM presented gender-specific associations between osteoporosis, body composition and grip strength. Grip strength and thigh SF thickness might serve as predictors for detection of osteoporosis in patients with T2DM.
Breast cancer with scalp metastases: a case report
Authors: Abdulraheem Ahmad M. , Naji Duha , Al Heyasat Ammar N. , Alhasan Mohammad , Almasri Nidal M. , Odeh Raghad
Published: May 2023

Background

While breast cancer is the most common cancer in women, cutaneous metastases are rare in breast cancer. Additionally, scalp involvement in breast cancer metastasis is extremely rare. That being said, scalp lesions should always be thoroughly investigated to distinguish metastatic lesions from other neoplasms.

Case presentation

A 47-year-old female Middle-Eastern patient presented with metastatic breast cancer in the lungs, bone, liver, and brain with no signs of multiple organ failure, in addition to cutaneous metastases, including the scalp. Between 2017 and 2022, she was managed through modified radical mastectomy, radiotherapy, and several lines of chemotherapy. She presented in September of 2022 with enlarging scalp nodules, which started developing 2 months prior to her presentation. Physical examination revealed firm, non-tender, and immobile skin lesions. Magnetic resonance imaging scan of the head showed soft tissue nodules in different sequences. A punch biopsy was taken from the largest scalp lesion and showed metastatic invasive ductal carcinoma. A panel of immunohistochemistry stains was applied, because a single specific marker for differentiating primary cutaneous adnexal tumors or other malignant neoplasms from breast cancer has not yet been identified. The panel showed positive estrogen receptor 95%, progesterone receptor 5%, negative human epidermal growth factor receptor 2, positive GATA binding protein 3, positive cytokeratin-7, negative P63, and negative KIT (CD117).

Conclusion

Breast cancer metastases to the scalp are extremely uncommon. When a scalp metastasis is present, it might be the only symptomatic sign of disease progression or widespread metastatic lesions. However, such lesions warrant a comprehensive radiologic and pathologic workup to rule out other possibilities of skin pathologies, such as sebaceous skin adenocarcinoma as it effects the management plan.
Comparison of the different animal modeling and therapy methods of premature ovarian failure in animal model
Authors: Dai Fangfang , Wang Ruiqi , Deng Zhimin , Yang Dongyong , Wang Linlin , Wu Mali , Hu Wei , Cheng Yanxiang
Published: May 2023

Incidence of premature ovarian failure (POF) is higher with the increase of the pace of life. The etiology of POF is very complex, which is closely related to genes, immune diseases, drugs, surgery, and psychological factors. Ideal animal models and evaluation indexes are essential for drug development and mechanism research. In our review, we firstly summarize the modeling methods of different POF animal models and compare their advantages and disadvantages. Recently, stem cells are widely studied for tumor treatment and tissue repair with low immunogenicity, high homing ability, high ability to divide and self-renew. Hence, we secondly reviewed recently published data on transplantation of stem cells in the POF animal model and analyzed the possible mechanism of their function. With the further insights of immunological and gene therapy, the combination of stem cells with other therapies should be actively explored to promote the treatment of POF in the future. Our article may provide guidance and insight for POF animal model selection and new drug development.

Graphical Abstract
miR-210-3p enriched extracellular vesicles from hypoxic neuroblastoma cells stimulate migration and invasion of target cells
Authors: Fusco Pina , Fietta Anna , Esposito Maria Rosaria , Zanella Luca , Micheli Sara , Bastianello Angelica , Bova Lorenzo , Borile Giulia , Germano Giuseppe , Cimetta Elisa
Published: May 2023

Background

Tumor hypoxia stimulates release of extracellular vesicles (EVs) that facilitate short- and long-range intercellular communication and metastatization. Albeit hypoxia and EVs release are known features of Neuroblastoma (NB), a metastasis-prone childhood malignancy of the sympathetic nervous system, whether hypoxic EVs can facilitate NB dissemination is unclear.

Methods

Here we isolated and characterized EVs from normoxic and hypoxic NB cell culture supernatants and performed microRNA (miRNA) cargo analysis to identify key mediators of EVs biological effects. We then validated if EVs promote pro-metastatic features both in vitro and in an in vivo zebrafish model.

Results

EVs from NB cells cultured at different oxygen tensions did not differ for type and abundance of surface markers nor for biophysical properties. However, EVs derived from hypoxic NB cells (hEVs) were more potent than their normoxic counterpart in inducing NB cells migration and colony formation. miR-210-3p was the most abundant miRNA in the cargo of hEVs; mechanistically, overexpression of miR-210-3p in normoxic EVs conferred them pro-metastatic features, whereas miR-210-3p silencing suppressed the metastatic ability of hypoxic EVs both in vitro and in vivo.

Conclusion

Our data identify a role for hypoxic EVs and their miR-210-3p cargo enrichment in the cellular and microenvironmental changes favoring NB dissemination.
An AHP enabled port selection multi-source decision support system and validation: insights from the ENIRISST project
Authors: Georgoulas Dimitrios , Koliousis Ioannis , Papadimitriou Stratos
Published: May 2023

Analytical Hierarchy Process (AHP) is a robust procedure for ranking options and supporting multi-criteria decision making that determine the port that a shipping operator will select, while designing the most cost-effective route. An important decision that may turn out to be decisive for a company’s survival. We developed an AHP based decision support system, as part of a wider Research and data Infrastructure system, that enables practitioners’ decision making based on their subjective experience and within realistic time constraints. We test the approach using two regional ports and the throughput results confirmed the initial expectations.
Psychometric validation of the collective asset Utu: associations with coping strategies and resilience during adolescence
Authors: Cherewick Megan , Dahl Ronald E. , Rubin Daphna , Leiferman Jenn A. , Njau Prosper F.
Published: May 2023

Background

Utu is a Kiswahili term with a long history of cultural significance in Tanzania. It conveys a value system of shared, collective humanity. While variants of Utu have been studied in other contexts, a measure of Utu that captures this important collective asset has not been developed in Tanzania. The aims of this study were to (1) examine dimensional constructs that represent Utu, (2) validate a measurement scale of Utu for use with adolescents, (3) examine differences between orphan and non-orphan adolescents in self-reported Utu and, (4) examine structural paths between adverse life experiences, coping strategies, Utu, and resilience. 

Methods

This study collected survey data from adolescents from three districts in peri-urban Tanzania in two samples: 189 orphan adolescents ages 10–17 in May 2020 and 333 non-orphan adolescents ages 10–14 in August 2020. Confirmatory factor analysis was used to validate the hypothesized factor structure of the developed Utu measure. Structural equation models were used to examine path associations with adverse life experiences, coping and resilience.

Results

The five dimensional constructs comprising the Utu measure included Resource Sharing, Group Solidarity, Respect and Dignity, Collectivity, and Compassion. Confirmatory factor analysis of the Utu measure demonstrated excellent fit (CFI = 0.98; TLI = 0.97; SRMR = 0.024; RMSEA = 0.046) and internal consistency (α = 0.94) among adolescents in this study. Positive, significant associations were found between Utu and coping (β = 0.29, p < 0.001) and Utu and intra/interpersonal and collective resilience (β = 0.13, p < 0.014). Utu was not significantly associated with adverse life experiences, age or gender.

Conclusions

A five-dimensional measurement scale for Utu was validated in a sample of orphan and non-orphan adolescents in Tanzania. Utu is a collective asset associated with higher levels of reported resilience in both orphan and non-orphan adolescent populations in Tanzania. Promoting Utu may be an effective universal public health prevention approach. Implications for adolescent programming are discussed.
“Medical student syndrome”: a real disease or just a myth?—a cross-sectional study at Menoufia University, Egypt
Authors: Sherif Huda A. , Tawfeeq Khaled , Mohamed Zahraa , Abdelhakeem Lobna , Tahoon Sara H. , Mosa Mahasen , Samy Karima , Hamdy Karema , Ellakwa Lamiaa , Elnoamany Salma
Published: May 2023

Background

A widely held belief is that “Medical student syndrome” is frequently experienced by young medical students, that is, they experience the symptoms of the diseases they are studying or fear of having such illness. A hypothesis is that because medical students constantly learn about life-threatening conditions and diseases, they experience persistent fear and stress regarding having a severe medical condition, an anxiety-related illness called nosophobia.

Results

Although medical students scored an average of 14.14 on a scale measuring potential nosophobia a, the difference between their scores and those of non-medical students, who scored an average of 0.11, is significantly higher (p 0.001). According to the presented analysis, non-medical and medical students exhibit distinct levels of nosophobia. The analysis of responses to hypochondriacal behaviors revealed that students from non-medical faculties scored an average of 1.43 points. By contrast, the average score for medical students was 7.87, which is significantly higher than that of the non-medical students (p 0.001).

Conclusions

Medical students are at higher risk for health anxiety and hypochondrial attitudes than non-medical students are.
Effect of zones' dimensions and geometry on seepage through zoned earth dams
Authors: Mostafa Mahmoud M. , Zhenzhong Shen
Published: May 2023

The seepage study through earth dams is very essential for the design and construction processes of such dams to ensure the needed safety and efficient performance. The present study focuses on the seepage flow through zoned embankment dams by introducing a numerical analysis using the Seep/w numerical model. The main objective of the study is to investigate the different effects of the dam zones' thickness and side slopes on seepage through such dams to achieve the most suitable dimensions and geometry of the different zones. First, the Seep/w is used to analyze the problem of seepage through earth dams with an internal core. The present obtained results and the results of other previous experimental and analytical studies are almost close to each other. The present work proves that the best relative thickness of the inner, transition, and outer zones (t1:t2:t3) according to the minimum seepage and cost of the used materials is 2:1.5:1.5 respectively. At the same time, it is proven that the reasonable optimum side slopes (H:V) of the inner, transition, and outer zones are 1:1.75, 1.25:1, and 3.75:1 respectively.
Long-Term Outcomes of TROG 13.01 SAFRON II Randomized Trial of Single- Versus Multifraction Stereotactic Ablative Body Radiotherapy for Pulmonary Oligometastases
Authors: Siva Shankar , Sakyanun Pitchaya , Mai Tao , Wong Wenchang , Lim Adeline , Ludbrook Joanna , Bettington Catherine , Rezo Angela , Pryor David , Hardcastle Nicholas , Kron Tomas , Higgs Braden , Le Hien , Skala Marketa , Gill Suki , Eade Thomas , Awad Raef , Sasso Giuseppe , Vinod Shalini , Montgomery Rebecca , Ball David , Bressel Mathias
Published: May 2023

Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported.

In a randomized phase II clinical trial, the Trans Tasman Radiation Oncology Group compared single- versus multifraction stereotactic ablative body radiotherapy (SABR) in 90 patients with 133 oligometastases to the lung. The study found no differences in safety, efficacy, systemic immunogenicity, or survival between arms, with single-fraction SABR picked as the winner on the basis of cost-effectiveness. In this article, we report the final updated survival outcome analysis. The protocol mandated no concurrent or post-therapy systemic therapy until progression. Modified disease-free survival (mDFS) was defined as any progression not addressable by local therapy, or death. At a median follow-up of 5.4 years, the 3- and 5-year estimates for overall survival (OS) were 70% (95% CI, 59 to 78) and 51% (95% CI, 39 to 61). There were no significant differences between the multi- and single-fraction arms for OS (hazard ratio [HR], 1.1 [95% CI, 0.6 to 2.0]; P = .81). The 3- and 5-year estimates for disease-free survival were 24% (95% CI, 16 to 33) and 20% (95% CI, 13 to 29), with no differences between arms (HR, 1.0 [95% CI, 0.6 to 1.6]; P = .92). The 3- and 5-year estimates for mDFS were 39% (95% CI, 29 to 49) and 34% (95% CI, 24 to 44), with no differences between arms (HR, 1.0 [95% CI, 0.6 to 1.8]; P = .90). In this patient population, where patients receive SABR in lieu of systemic therapy, one-in-three patients are alive without disease in the long term. There were no differences in outcomes by fractionation schedule.
Selective Tibial Neurotomy Outcomes for Spastic Equinovarus Foot: Patient Expectations and Functional Assessment
Authors: LaMarca Amber L. , Krenn Matthias J. , Kelso-Trass Molly A. , MacDonald Kathryn C. , Demeo Cristina C. , Bazarek Stanley F. , Brown Justin M.
Published: May 2023

BACKGROUND:

Spastic equinovarus foot (SEF) is a common dysfunctional foot posture after stroke that impairs balance and mobility. Selective tibial neurotomy (STN) is a simple but underutilized surgical option that can effectively address critical aspects of SEF and thereby provide enduring quality of life gains. There are few studies that examine both functional outcomes and patient satisfaction with this treatment option.

OBJECTIVE:

To elucidate the patient goals that motivated their decision to undergo the procedure and compare subjective and objective changes in balance and functional mobility as a consequence of surgery.

METHODS:

Thirteen patients with problematic SEF who had previously failed conservative measures were treated with STN. Preoperative and postoperative (on average 6 months) assessments evaluated gait quality and functional mobility. In addition, a custom survey was conducted to investigate patient perspectives on STN intervention.

RESULTS:

The survey showed that participants who opted for STN were dissatisfied with their previous spasticity management. The most common preoperative expectation for STN treatment was to improve walking, followed by improving balance, brace comfort, pain, and tone. Postoperatively, participants rated the improvement in their expectations and were, on average, 71 on a 100-point scale, indicating high satisfaction. The gait quality, assessed with the Gait Intervention and Assessment Tool, improved significantly between preoperative and postoperative assessment (M = −4.1, P = .01) with a higher average difference in stance of −3.3 than in swing −0.5. Improvement in both gait endurance (M = 36 m, P = .01) and self-selected gait speed (M = .12 m/s, P = .03) was statistically significant. Finally, static balance (M = 5.0, P = .03) and dynamic balance (M = 3.5, P = .02) were also significantly improved.

CONCLUSION:

STN improved gait quality and functional mobility and was associated with high satisfaction in patients with SEF.
Diagnosis and imaging in COVID-19 induced myositis
Authors: Abid Sohail Zaynab , Naqvi Jawad , Gray Leanne
Published: May 2023

The case describes how musculoskeletal disease can manifest in coronavirus disease. The most reported symptoms of covid infection are cough, fever and myalgia. Myalgia and myositis are similar conditions in that they both describe muscular pain and fatigue. However, they are distinguishable in that myalgia is usually benign and self-limiting whilst untreated myositis can lead to serious complications often requiring hospital admission. This case report aims to familiarise physicians with atypical presentations of coronavirus disease to prevent delays in diagnosis and treatment. Timely treatment of covid-induced myositis can decrease in-hospital mortality rates and improve patient outcomes.
Effect of in-office bleaching agent on the surface roughness and microhardness of nanofilled and nanohybrid composite resins
Authors: Chakraborty Anindita , Purayil Tina , Ginjupalli Kishore , Pentapati Kalyana-Chakravarthy , Shenoy Neetha
Published: May 2023

Background: To compare the surface roughness and microhardness of Ceram.x® SphereTEC™ one and Filtek Z350 XT after in-office bleaching with Pola office.

Methods: Twenty samples each of (10 mm diameter and 2 mm height) Ceram.x® SphereTEC™ one and Filtek Z350 XT were prepared. The samples were subjected to three bleaching sessions with 35% hydrogen peroxide (Pola office) with a seven-day interval between each session. Surface roughness and microhardness of the prepared samples prior to and after the bleaching regimen were measured using a profilometer and Vickers hardness tester, respectively.

Results: A significant reduction (p <0.001) in the surface hardness of Filtek Z350 XT from 27.67 ± 2.10 to 17.83 ± 1.36 Vickers hardness number (VHN) was observed after the bleaching whereas no significant reduction in surface hardness was observed with Ceram.x® SphereTEC™ one. The adjusted mean (estimated marginal mean) microhardness after bleaching for Ceram.x ® SphereTEC™ one (35.79 ± 1.45) was significantly higher than Filtek Z350 XT (19.54 ± 1.45) (p < 0.001). However, in-office bleaching of these materials did not significantly alter their surface roughness.

Conclusions: In office-bleaching with 35% hydrogen peroxide can reduce the microhardness of nanofilled composite. However, the surface roughness was not influenced by the bleaching procedure in both nanohybrid and nanofilled composite resin materials.
Comparative evaluation of the effect of 2% graphene oxide and 5% hydroxyapatite nanoparticles in isolation and in combination on micro tensile bond strength of 5th generation adhesive
Authors: Kriplani Simran , Sedani Shweta
Published: May 2023

Graphene is the thinnest, strongest and stiffest imaginable material. The biocompatible property of graphene oxide can initiate and facilitate cell adhesion, proliferation and differentiation of periodontal ligament, osteogenic and oral epithelial cells. Furthermore, the antibiofilm and anti-adhesion properties of graphene oxide in prevention of dental biofilm infections, dental caries, dental erosion as well as for implant surface modification and as anti-quorum sensing agent.

Composites are most often utilised materials for restoration in the field of dentistry due to adhesive resins' improved mechanical and cosmetic properties. To safeguard the dentin and prevent dental cavities, dentin adhesives are utilised to affix hydrophobic resin composites to hydrophilic dentin tissue. Dental adhesives have a harder time adhering to dentin because it contains more water and is less mineralized than enamel. This makes the method more sensitive. As a result, it was chosen to assess and contrast the impact of 5% Hydroxyapatite nanoparticles and 2% Graphene oxide nanoparticles, both separately and together, on the Micro tensile bond strength of 5th generation adhesive. Graphene oxide is the most versatile form of Graphite in structural and functional configuration. Graphene oxide possess extraordinary physical, chemical, optical, electrical and mechanical properties. Among the graphene family nanomaterials, the reduced form of Graphite adding the oxygenated functional group to the structure increases the surface area and therefore exhibits enviable excellent interaction ability with metal and ions as well as organic species. Graphene oxide in dentistry has provided outstanding results in antimicrobial action, regenerative dentistry, bone tissue engineering, drug delivery, physicochemical property, enhancement of dental biomaterials and oral cancer treatment.
The journey of F1000Research since inception: through bibliometric analysis
Authors: Kumar Dilip , Shandilya Abhinav Kumar , Srivastava Sandeep
Published: May 2023

Background: Bibliometric analysis is an approach adopted by researchers to understand the various analytics such as year-wise publications, their citations, most impactful authors and their contributions, identification of emerging keywords, multiple themes (niche, motor, basic, and emerging or declining) etc. F1000Research is one of the Q1 category journals that publishes articles in various domains, but a detailed journal analysis is yet to be done.

Methods: This study is an effort to extract the F1000Research journey information through bibliometric analysis using VOS-viewer and Biblioshiny (R-studio) interface. The F1000Research journal started its journey in 2012; since then, 5767 articles have been published until the end of 2022. Most of the published articles are from medical science, covering Biochemistry, Genetics & Molecular Biology, Immunology & Pharmacology, Toxicology & Pharmaceutics. To understand the research journey, various analyses such as publication & citation trends, leading authors, institutions, countries, most frequent keywords, bibliographic coupling between authors, countries and documents, emerging research themes, and trending keywords were performed.

Results: The United States is the biggest contributor, and COVID-19 is the most commonly occurred keyword.

Conclusions: The present study may help future researchers to understand the emerging medical science domain. It will also help the editors and journal to focus more on developing or emerging areas and to understand their importance towards society. Future researchers can contribute their quality research studies, focusing on emerging themes. These authors’ research can guide future researchers to develop their research area around the most impacted articles. They can collaborate with them to bring that emerging theme forward.
Teacher professional development in educational dialogue: lessons from a massive open online course
Authors: Brugha Meaghan , Ahmed Farah
Published: May 2023

Online teacher professional development (TPD) courses have become increasingly prevalent, particularly since the coronavirus disease (COVID-19) pandemic, and may offer continued support for the formation and sustainability of teacher communities of practice in a post-pandemic world. This study explores the format and structure of one form of online TPD delivery through the analysis of a massive open online course (MOOC) designed for educators on the fundamentals of educational dialogue. This research examines and reconsiders the ways in which we learn, teach and commune as professionals and learners online. It also explicitly builds on previous research conducted by Brugha and Hennessy, which offers 10 design principles for scalable and sustainable online professional learning programmes that promote practitioner reflection, agency, and empowerment.
RESEARCH OF THE PROBLEMS OF THE PERSONNEL POTENTIAL OF THE REGIONS OF THE RUSSIAN FEDERATION
Authors: Kalyugina Svetlana N. , Karamysheva Dina B. , Larionova Natalia A.
Published: May 2023

The article discusses the features of strategic development in the regions of the Russian Federation. The main purpose of the study was to study the prerequisites for the formation of the country’s human resources potential. An article are evaluated the potential labor resources. An assessment of potential labor resources is being carried out. The analysis of population indicators in the subjects of the Russian Federation was carried out, age groups of the population were studied, the level of education of people of working age was studied. The indicators of the level of employment and unemployment are analyzed, the level of development of the personnel potential of the regions is revealed. The analysis of regional development strategies is carried out. In the course of the study, the most promising regions of Russia were identified. The vectors for solving the problems of regional development are determined, taking into account the construction of a socially-oriented personnel policy. A model of the effectiveness of the economic development of the region is presented. Reasonable conclusions are made about the need to increase investments in the human resources potential of the regions for the stable development of the country in the long term.
SPORTS BOARD GAMES AS A MEANS OF PHYSICAL EDUCATION FOR STUDENTS OF SPECIAL MEDICAL GROUPS IN THE CONTEXT OF THE INCLUSIVE EDUCATION DEVELOPMENT
Authors: Kozlov Aleksey V. , Kulkova Irina V. , Kozlova Maria A.
Published: May 2023

The article deals with the nuances of organizing work on physical education with students of SMG (special medical groups) by means of sports board games.

The relevance of the study is substantiated by the need to search for new forms of physical activity of students with disabilities (limited health).

The aim of the study is to analyze physical culture and health-improving activity in higher educational institutions using the example of a competitive event in sports board games among students of a special medical group and the main health group (MHG). The emphasis of the work is made on the need to introduce board sports games into the educational activities of higher professional institutions. It is concluded that sports board games contribute to the development of an inclusive educational environment, are a good means of health preservation and are suitable for students with any type of pathology.

Methodology. In accordance with the intended scientific goal and the results of the scientific experiment, points were calculated and converted into a percentage.

Results. As a result of the study, the effectiveness of the use of table sports for the development of an inclusive educational environment in higher educational institutions has been scientifically substantiated and experimentally proven.

Practical implications. The practical application and introduction of board sports games into the educational process will help teachers and teachers of universities and colleges to adapt extracurricular and competitive activities for students of a special medical group.