bluuebunny/crossref_metadata_2025 huggingface dataset:
Group-Based Trajectory Modelling (GBTM) To Assess the Effect of Medication Adherence on Health-Related Outcomes: A Protocol for A Systematic Review
Authors: Memoli Victoria , Ekanmian Giraud , Lunghi Carlotta , Bouhnik Anne-Déborah , Lauzier Sophie , Guénette Line
Published: June 2021

Background: The Group-based trajectory modelling (GBTM) method is increasingly used in pharmacoepidemiologic studies to describe medication adherence trajectories over time. However, assessing the effects of these medication adherence trajectories on health-related outcomes remains challenging. The purpose of this review is to describe studies assessing the effects of medication adherence trajectories estimated by the GBTM method on health-related outcomes. Methods: We will conduct a systematic review according to the recommendations of the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) guidelines. We will search in the following databases: PubMed, Embase, PsycINFO, Web of Science, CINAHL, and Cochrane database up to April 1st, 2021. Two reviewers will independently select articles and extract data. Discrepancies at every step will be resolved through discussion, and consensus will be reached for all disagreed articles. A third reviewer will act as a referee if needed. We will use tables to synthesize the modalities used to estimate medication adherence trajectories and the effect of adherence trajectories on health-related outcomes. We will identify the types of health-related outcomes studied and how they are defined, the statistical models used, the effect measure yield, and how medication adherence trajectories have been incorporated in the model. We will also review the limitations and biases reported by the authors and their attempts to mitigate them. We will provide a narrative synthesis.Discussion: This review will provide a clear view of the strategies and methods used in medication adherence research to estimate the effects of adherence trajectories on different health-related outcomes. A thorough exploration of how GBTM is used for this specific purpose could represent the first crucial steps towards optimizing the utilization of this method in adherence studies. Systematic review registration: Prospero CRD42021213503.
Activin A Improves White Matter Injury in Neonatal Rats via Noggin/bmp4/id2 Signaling
Authors: Su Xiaojuan , Tang Jun , Huang Lingyi , Xiao Dongqiong , Qiu Xia , Ying Junjie , Li Shiping , Pradhan Rina , Liu Qian , Zhao Fengyan , Qu yi , Mu Dezhi
Published: June 2021

BackgroundActivin A (Act A) has been revealed to enhance the differentiation of oligodendrocyte progenitor cells (OPCs) in vitro. Here we aim to elucidate its roles and mechanisms in a rat model of white matter injury (WMI). MethodsAct A was injected into the lateral ventricle of a hypoxia-ischemia induced WMI rat model. Hematoxylin & eosin staining was used to detect pathological changes. Immunofluorescence staining was used to assess OPC proliferation, migration, apoptosis, and differentiation. Myelin sheath and axon formation were detected via immunofluorescence staining, Western blotting, and electron microscopy. Behavioral assessment of rats was performed with the Morris water maze test. ResultsAct A attenuated the pathological damages, enhanced the formation of myelin sheath and myelinated axons and improved the behavior of WMI rats by promoting OPC proliferation and differentiation. However, Act A showed no significant effects on OPC migration or apoptosis. Interestingly, we found that Act A could enhance Noggin expression, which in turn inhibited the expression of bone morphogenetic protein 4 (BMP4) and inhibitor of DNA binding 2 (Id2). Furthermore, upregulation of Id2 completely abolished the protective effects of Act A in WMI. Conclusions﻿Act A improves WMI in neonatal rats via Noggin/BMP4/Id2 signalling.
Antibiotic Resistance in Aerobic Bacterial Isolates From Infected Diabetic Foot Ulcers in North Eastern Tanzania: An Urgent Call to Establish A Hospital Antimicrobial Stewardship Committee
Authors: Shabhay Ahmed Ali , Horumpende Pius , Mujuni Martin , Munisi Edna-Joy , Mshana Stephen , Shabhay Zarina , Mganga Andrew , Chilonga Kondo , Msuya David , Chilongola Jaffu O. , Baal Jeff Van , Chugulu Samwel
Published: June 2021

Background.

Diabetic foot ulcers (DFU) is among major health problems which impact the socio economic burden globally. We aimed at assessing the susceptibility pattern of antimicrobials in DFU infections among patients admitted in the Surgical Department at Kilimanjaro Christian Medical Centre (KCMC).
Methods.

This descriptive cross-sectional study was conducted from September 2018 through March 2019. Pus swabs were collected on the first day of admission by deep wound swabbing after irrigation with normal saline solution. Kirby-Bauer method was done according to the Clinical and Laboratory Standard Institute (CLSI) guidelines.
Results.

Sixty diabetic ulcer patients had 62 bacterial isolates. Majority of the isolates were gram negative 49/62(79.03%). The most common isolate was Escherichia coli 15/62(24.19%) followed by Pseudomonas aeruginosa 14/62(22.58%), Proteus mirabilis 8/62(12.9%) and Staphylococcus aureus 5/62(8.06%). Klebsiella pneumoniae, Coagulase Negative Staphylococcus, Proteus Vulgaris, and Streptococcus pyogenes each contributed 4/62(6.25%) isolates. Of the 49/62(79.3%) gram negative isolates, 8/49(16.33%) were mono resistant, 30/49(61.22%) were multiresistant, and 11/49(22.45%) were susceptible. Of the multi-resistant isolates, E. coli 12/15(80.00%), and P.aeruginosa 7/14(50.00%) were predominant. A total of 39/62(62.90%) isolates in patients contributed to poorer outcomes including loss of body part. Patients with ulcers infected by P. aeruginosa 11/39 (28.21%) had the highest number of surgical removal of body parts followed by E. coli 8/39(20.51%). Gram negative bacteria were highly susceptible to amikacin 91.18%, meropenem 93.33% and imipenem 95.24%. Isolates susceptibility to ceftriaxone was 32%.
Conclusions.

Amikacin, meropenem and imipenem can be safely used as broad-spectrum antimicrobials in DFU. The Standard of care remains culture and sensitivity of isolated microorganisms in combating diabetic foot ulcers infections.
Susceptibility to Imipenem/Relebactam of Pseudomonas Aeruginosa and Acinetobacter Baumannii Isolates From Chinese Intra-Abdominal, Respiratory and Urinary Tract Infections: SMART 2015 To 2018
Authors: Zhang Hui , Jia Peiyao , Zhu Ying , Zhang Ge , Zhang Jingjia , Kang Wei , Duan Simeng , Zhang Weijuan , Yang Qiwen , Xu Yingchun
Published: June 2021

Background

In recent years, less options are available for treating carbapenem-resistant Acinetobacter baumannii and carbapenem-resistant Pseudomonas aeruginosa. The present study investigatesthe susceptibility rates to imipenem/relebactamfor the treatment of intra-abdominal infections (IAIs), respiratory tract infections (RTIs) and urinary tract infections (UTIs) caused by A. baumannii and P. aeruginosain China.
Methods

1,886 P. aeruginosa and 1,889 A.baumanniiisolates were collected in 21 centers (7 regions) as part of the global SMART surveillance program between 2015 and 2018. Antimicrobial susceptibility testing was performed according tothe Clinical and Laboratory Standards Institute (CLSI) recommendations using the broth microdilution methodology in the Peking Union Medical College Hospital.
Results

Rates of imipenem-non-susceptibilities of P. aeruginosa and A. baumanniiisolates were 44.3% and 79.0%, whereas the multidrug-resistance (MDR) rateswere 44.3% and 81.9%, respectively.For P. aeruginosa, susceptibility rates to imipenem/relebactamwere 84.2% at aCLSI breakpoint of ≤ 2 mg/L compared to 55.7% for imipenem. The MIC90 of imipenem/relebactam(8 mg/L) was one fourth of that of imipenem (32 mg/L).The susceptibilities of imipenem-non-susceptible and MDRP.aeruginosastrains were similarly restored by imipenem/relebactam in non-ICU and ICU wards.The susceptiblity rate of A. baumannii isolates to imipenem was 21.0% and to imipenem/relebactam 22.2%.
Conclusions

Imipenem/relebactam provides a therapy option for infections caused by MDRor imipenem-non-susceptible P. aeruginosa infections in China.
Gut microbiome-wide association study of depression
Authors: Radjabzadeh Djawad , Bosch Jos , Uitterlinden André , Zwinderman Koos , Ikram M. Arfan , Meurs Joyce van , Luik Annemarie , Nieuwdorp Max , Lok Anja , Duijn Cornelia van , Kraaij Robert , Amin Najaf
Published: June 2021

Depression is one of the most poorly understood diseases due to its elusive pathogenesis. There is an urgency to identify molecular and biological mechanisms underlying depression and the gut microbiome is a novel area of interest. In this study we investigated the relation of fecal microbiome diversity and composition with depression in 1,054 from the Rotterdam Study cohort and validated these findings in the Amsterdam HELIUS cohort in 1,539 subjects. Using supervised and unsupervised machine learning approaches, we identified and replicated the association of several microbial genera. We confirm the association of genus Eggerthella, Subdoligranulum, Coprococcus and family Ruminococcaceae and identify novel bacteria including Sellimonas, Lachnoclostridium, Hungatella, Ruminococcaceae (UCG002,UCG003 and UCG005), LachnospiraceaeUCG001, Eubacterium ventriosum and Ruminococcusgauvreauiigroup associated with depression. These bacteria are known to be involved in the synthesis of glutamate, butyrate, serotonin and gamma amino butyric acid (GABA), which are key neurotransmitters for depression. Our study suggests the gut microbiome composition may play a key role in depression.
Exosome Releasing HSPD1 Assists HNF1A in Regulating the Invasion Ability and Radiosensitivity of Esophageal Squamous Cell Carcinoma Cells via Activating EMT
Authors: Zou Naiyi , Dong Jing , Zhang Xueyuan , Li Shuguang , Li Youmei , Zhao Yan , Xu Jinrui , Zhu Shuchai
Published: June 2021

Background: Concurrent chemoradiotherapy is the standard scheme for locally advanced non-surgical esophageal squamous cell carcinoma (ESCC). But there are frequently different results due to tumor heterogeneity. HNF1A and HSPD1 have been shown to be associated with the invasion, proliferation, apoptosis, and chemical resistance in multiple cancers. The aim of this study was to investigate the effects of HNF1A and HSPD1 on invasion and radiosensitivity of ESCC.Methods: HNF1A was overexpressed by lentivirus transfection and HSPD1 was silenced by knockdown plasmid in TE1 and KYSE150 cells. The mRNA expression of HSPD1 and HNF1A were detected by RT-qPCR. The correlated proteins expression was verified by western blot, and transwell tested the invasion ability of ESCC cells. Survival curve was plotted by colony formation assay. Co-immunoprecipitation and immunofluorescence assays were used to detect interaction and subcellular location of HNF1A and HSPD1. At the same time, we explored the change of HSPD1 protein in exosomes by western blotting.Results: Immunoprecipitation and mass spectrometry identified the combination of HNF1A and HSPD1/hnRNPA1/A3/TCP1 in TE1 cells. Co-immunoprecipitation and immunofluorescence experiments were verified the bind of HNF1A and HSPD1 again, but HNF1A did not regulate HSPD1 expression. Subsequently, HSPD1 knockout reversed HNF1A to promote invasion ability of cells by inhibiting EMT. Likewise, deletion of HSPD1 relieved radio-resistance from overexpression of HNF1A in TE1 and KYSE150 cells. Notably, induced cells to release abundant of HSPD1 through exosome, and ectopic expression of HNF1A prevented radiation-induced exosomal releasing of HSPD1.Conclusions: We initially demonstrated that HNF1A was assisted by HSPD1 to drive EMT process and promote invasion of ESCC cells, and explained that HNF1A prevented HSPD1 from releasing to extracellular with exosomes after irradiation, thereby causing radio-resistance. These findings provided theoretical basis of gene target treatment for radiotherapy of ESCC.
MiR-219-5p is Involved in the Proliferation, Migration and Invasion of Oral Cancer Through SOX5 Regulation
Authors: Zhou Ting , He Ying , Dong Xiao-Han , Chen Bo , Ton Jun , Xiyang Yan-Bin , Mao Rui
Published: June 2021

Purpose Oral cancer has the characteristics of rapid progression, wide invasion and poor prognosis, which induces higher mortality in the patients. At present, there are about 300 thousand new cases of oral cell carcinoma worldwide. Particularly, the incidence rate of oral cancer in China is relatively high. Therefore, it urgently needs to understand the pathogenesis of oral cancer and molecular mechanisms underlying. Abnormal regulation of miR-219-5p is present in various types of cancer. However, the relationship between miR-219-5p and its targets in oral cancer has not been well evaluated. Methods Western blotting and Quantitative RT-PCR were used to detect the expression of SOX5 in oral cancer tissues.Migration ,cell proliferation,and invasion were detected using CCK8 assay,Conlony formation assay and Transwell assays .The interaction between SOX5 and miR-219-5p and oral cancer was confirmed using dual-luciferase reporter assays.Result This study aims to investigate the possible roles of miR-219-5p and its potential target gene, SOX5, in the progress of oral cancer. Our data showed that the high miR-219-5p and low SOX5 expression levels were associated with improved survival rates in patients. miR-219-5p level was negatively correlated with the expression of SOX5. Genetic analysis and luciferase assay revealed that the miR-291-5p regulated SOX5 expression by targeting the 3'-UTR region of SOX5 mRNA. Functionally, we confirmed that miR-219-5p mimics inhibited SOX5 expression and suppressed the proliferation, colony formation ability, invasion and migration of oral cancer cells, SCC4 and SCC9. In contrast, inhibition of miR-219-5p increased SOX5 levels and promoted the vitality and mobility of oral cancer cells. Furthermore, special siRNA targeting SOX5 partially neutralized the effects of miR-219-5p inhibitor. Conclusions This study demonstrates that miR-219-5p may inhibit the proliferation, migration and invasion of oral cancer by targeting the expression of SOX5, which provided novel candidates for clinic prognosis and/or therapy.
Association of significantly elevated serum levels of NGAL and IGFBP4 in patients with diabetic nephropathy
Authors: Ali Hamad , Abu-Farha Mohamed , Alshawaf Eman , Devarajan Sriraman , Bahbahani Yousif , Al-Khairi Irina , Cherian Preethi , Alsairafi Zahra , Vijayan Vidya , Al-Mulla Hamad , Attar Abdulnabi Al , Abubaker Jehad
Published: June 2021

Background: Diabetic nephropathy (DN) is a kidney-related complication affecting approximately 40% of patients with diabetes. Current DN diagnostic criteria predominantly rely on albuminuria and serum creatinine levels; however, the specificity and reliability of both markers are limited. Hence, reliable biomarkers are required to diagnose and effectively manage DN progression. Methods: Here we investigated the expression level and the association between neutrophil gelatinase-associated lipocalin (NGAL), IGFBP-1, IGFBP-3, and IGFBP-4 in patients with DN and compared it to patients with T2D and control participants. A cohort comprise of 159 individuals (DN = 67) was clinically evaluated and circulatory levels of NGAL, IGFBP1, IGFBP3, and IGFBP4 were determined using ELISA. Results: Levels of circulating NGAL were significantly higher in people with DN compared to people with T2D and non-diabetic groups (92.76 ± 7.5, 57.22 ± 8.7, and 52.47 ± 2.9 mg/L, respectively; p < 0.0001). IGFBP4 showed a similar pattern, where it was highest in people with DN (795.61 ng/ml ±130.7) compared to people with T2D and non-diabetic respectively (374.56 ng/ml ±86.8, 273.06 ng/ml ±27.8, ANOVA p<0.01). Our analysis presents a significant positive correlation between NGAL and IGFBP4 in people with DN (ρ =.620, p <0.005). IGFBP4 also correlated positively with creatinine level and negatively with eGFR, in people with DN supporting its involvement in DN. Conclusion: Our results report the association between the rise in NGAL and IGFBP4 levels in DN and suggest them as potential markers to aid DN diagnosis.
Active Fault Tolerant Nonsingular Terminal Sliding Mode Control for Electromechanical System Based on Support Vector Machine
Authors: Hu Jian , Yang ZhengYin , Yao JianYong
Published: June 2021

At present, electromechanical actuator is very popular in the industrial field because of environmental protection, energy saving and high efficiency. At the same time, it also puts forward higher requirements for its reliability. In this paper, a fault tolerant nonsingular terminal sliding mode control method for electromechanical system based on support vector machine (SVM) is proposed. SVM is designed to estimate the possible faults in the system by off-line learning from large sample data with gradient descent method. The estimation is used to compensate the possible fault with feedforward cancellation technique in the proposed controller. An observer is designed to estimate the system states to make fault detection and reconstruct the controller when something is wrong in electromechanical system. A nonsingular terminal sliding mode surface is designed, and Lyapunov theorem is used to derive a parameter adaptation law for handling the parametric uncertainty and a nonsingular terminal sliding mode control law. It is guaranteed the proposed controller can achieve bounded stability. Extensive comparative simulation and experimental results illustrate the effectiveness and advancement of the proposed controller compared with several other main-stream controllers.
Modeling the longitudinal outcomes of congestive heart failure patients: A case study at Wachemo University Nigist Eleni Mohammed Memorial Referral Hospital
Authors: Sultan Mohammed , Ahmed Ritbano
Published: June 2021

The linear mixed model is one of the common models used to analyze the longitudinal data;it may comprise of separate (Univariate), joint Bivariate, and joint Multivariate linear mixed model, which is predicted on the number of response variables incorporated in the analysis. Adjusting for correlation matrix and covariance matrix between and within subjects is one reason why modern longitudinal data analysis techniques are deemed more appropriate than some of the previous methods of analysis. Some studies assume that the correlation between observation is zero. However, it is unlikely that repeated measurements on the same individual Will actually be independent. To that end, comparing the different linear mixed models identifying the appropriate model demonstrates that the evolution of patients with congestive heart failure is necessary.In this study the separate, bivariate, and multivariate linear mixed models were compared with different covariance and correlation structures. Finally, a multivariate linear mixed model with autoregressive order one correlation structure and unstructured covariance structure for random effects, to consider within and between patient's variations, was considered as a best model to depict the evolution of patients with congestive heart failure.
A Review of Trends and Crime Patterns of Arson Offences in India: 2009-2018
Authors: Savia Fernandes Glorita , Mulimani C. F.
Published: June 2021

Crime statistics provide innate knowledge on different types of crimes, their jurisdictions, current status and future predictive trends in society. This research paper is based on the review of data available in the national open access publication of crime data in the country. It focuses on arson offences in India for the last decade from 2009 to 2018. It is important to study national crime statistics to enhance policing and criminological studies in different trends encountered through research. Explaining the trends of a crime in a country can help in establishing better policies, reporting systems, investigative methods and ultimately, a better criminal justice system. While Criminology studies have been generally focused on behavior, causes, etc. associated with violent crimes like offences against the body, violence against women, offences against children; this paper is aimed at discussing trends with respect to arson, a lesser known offence in our country.
O lúdico no ensino de biologia celular: possibilidades no ensino superior
Authors: MARRIEL Nadja Biondine , LADEIRA Luiz Carlos Maia , ARAÚJO Renan dos Santos , SILVA Janaina da , MARTINS Ana Luiza Pereira , TAVARES Mara Garcia
Published: June 2021

Considerando as dificuldades que alguns alunos recém-ingressos na Universidade apresentam para compreender conceitos abstratos, este trabalho descreve um Curso de Extensão, na área de Biologia Celular, que foi realizado com o objetivo de contribuir com a aprendizagem efetiva de um grupo de graduandos da Universidade Federal de Viçosa (MG). O trabalho relata também a importância da experiência vivenciada para os pós-graduandos que ministraram o Curso. No Curso foram utilizadas atividades lúdicas diversificadas, escolhidas de acordo com o tema que seria abordado. Os resultados mostraram que o Curso foi muito bem aceito pelos graduandos, ajudando na compreensão dos conteúdos, através de um processo agradável e acessível, que viabilizou a construção dos saberes. Para os discentes da pós-graduação que ministraram o Curso, a experiência foi única e contribuiu para sua formação profissional dos mesmos. Portanto, a experiência foi significativa para todos os envolvidos.
Twenty-Five Years of the Asian Academy of Management Journal (AAMJ): Intellectual Structure Mapping and Bibliometric Review
Authors: Imran Ahmed Shahzad  , Atallah Fahed Alserhan  , Muhammad Farrukh  , Nilufar Yasmin  , Jason Wai Chow Lee
Published: June 2021

In commemoration of the 25th anniversary of the Asian Academy of Management Journal (AAMJ), this study presents a general overview on the publication structure of the journal from 1996 to 2019. The study identifies the most productive authors, universities, and countries mainly using the Scopus database. It also enlists the most cited documents of the journal. Besides, the study graphically maps the intellectual structure based on co-citation, bibliographic coupling, and co-occurrence of authors’ keywords. The findings show the prominent Asian profile of the journal where most of the contributions come from the Asian countries and the universities. Specifically, authors from Malaysia and India remain the most frequent contributors. These findings provide readers of AAMJ with an objective overview of the trends of the journal. The study may be useful for future contributors as it provides inputs for the future research agenda.
Growth and Fecundity of Several Weed Species in Corn and Soybean
Authors: Clay S. A. , Kleinjan J. , Clay D. E. , Forcella F. , Batchelor W.
Published: June 2021

Do weeds that emerge later in the season justify additional control costs? If crop yield is not reduced or few or no seeds are added to the soil seed bank, then no control may be needed. Eight weed species were sown in corn (Zea mays L.) and soybean [Glycine max (L.) Merr.] (i) before crop emergence, (ii) at crop emergence, (iii) at V‐1, and (iv) at V‐2 stages of crop growth in 2002 and 2003. Weed seed was sown close to the crop row and thinned to 1.3 plants m−2. Weed growth and fecundity were influenced by species, time of planting, and year. Only barnyardgrass (Echinochloa crus‐galli L.), redroot pigweed (Amaranthus retroflexus L.), and velvetleaf (Abutilon theophrasti L.) survived to produce seed. Plants from the pre‐emergence seeding had the largest canopy and produced the most seeds. Barnyardgrass had maximum canopy cover in early July in corn and late July in soybean but only produced seed in corn. Redroot pigweed and velvetleaf had maximum canopy cover in late August or mid‐September, and some plants from most seeding dates survived and produced seed in both corn and soybean. However, plants that grew from seed sown at V‐1 and V‐2 crop growth stages did not reduce yield or biomass of adjacent crop plants, had low fecundity, and may not warrant treatment. Control may be necessary, however, to prevent yield losses if weeds are present at high densities or to prevent establishment of uncommon species.
Philosophical Counselling, Personal Brand, and Social Networks in the Digital Era
Authors: Frunză Sandu
Published: June 2021

U radu se argumentira da filozofijsko savjetovanje mora razviti prakse u
kontekstu u kojem svjedočimo rekonstrukciji perspektiva o svijetu i čovjeku putem revolucije razvoja interneta, društvenih mreža, komunikacijskih tehnologija i pristupa virtualnom svijetu. Filozofijsko i
etičko savjetovanje pozvano je uključiti se u raznovrsna nova područja aktivnosti, uključujući izgradnju osobnog oznaka u društvenim medijima, što je fokus ovog rada. S obzirom na to da virtualni komunikacijski prostor postaje medij učinkovitog izražavanja osobnosti, društveni mediji polje su u kojem filozofijsko i etičko savjetovanje mogu postati glavni resurs za rast snažnog osobnog oznaka. Bilo da se radi o samopromociji ili savjetovanju specijaliziranom za komercijalne komunikacije i oznakovljenje, tehnički razvoj omogućuje tehniku samorazvoja poduprtu relacijskim univerzumom društvenih medija. U digitalnom svijetu filozofijsko savjetovanje donosi povećanje doprinosa mogućnosti da se pojedinci izgrađuju, bivaju prepoznati i uživaju kompleksnu izloženost rukovođenu duhom društvene odgovornosti.
Natural Selection, Levelling, and Eternal Recurrence
Authors: Gellens Sven , Biebuyck Benjamin
Published: June 2021

Ovaj se rad bavi aktualnom raspravom o Nietzscheovoj vezi s darvinizmom, usmjeren na posebno značenje Nietzscheova integrativnog razmatranja evolucije u njegovim spisima. Istražujući rječnik evolucije u njegovim raspravama o volji za moć i kriticizmu Malthusova pojma prilagodbe, radom se tvrdi da je takozvana anti-darvinistička pozicija u Nietzscheovim kasnim spisima dio njegova obuhvatnog pokušaja da nadiđe uske granice strogo anatomskobiološkog ili društveno-darvinističkog pojma evolucije. Da Nietzsche to čini služeći se biologijskim rječnikom pokazuje njegova revnost u kartiranju utjecaja bioloških i kulturnih sila na ljudsku evoluciju. Radom se aktualna rasprava o kulturi i evoluciji želi smjestiti u širu povijesnu perspektivu. Istovremeno, želi doprinijeti i boljem razumijevanju Nietzscheove filozofijske antropologije, a posebno, njegove mijenjajuće ideje o slabosti i snazi, o intelektu i vječnom vraćanju istoga kao principu selekcije – ideje koje je Nietzsche razvio u nastojanju da nadiđe tradicionalnu podjelu tijela i uma.
Duality in quantum transport models
Authors: Frassek Rouven , Giardinà Cristian , Kurchan Jorge
Published: June 2021

We develop the `duality approach', that has been extensively studied for classical models of transport, for
quantum systems in contact with a thermal `Lindbladian' bath.
The method provides (a) a mapping of the original model to a simpler one, containing only a few particles and (b)
shows that any dynamic process of this kind with generic baths may be mapped onto one with equilibrium baths.
We exemplify this through the study of a particular model: the quantum symmetric exclusion
process introduced in [1]. As in the classical case, the whole construction becomes intelligible by
considering the dynamical symmetries of the problem.
Organizational conflicts in hospitals and their impact on employee turnover: A case study of Jordan
Authors: Al-Khasawneh Akif , Abu Khadar Bassam
Published: June 2021

The research aims to investigate the most common types of organizational conflicts among employees in private hospitals and discover the impact of organizational conflicts on employee turnover. The research outlined the relationship between the variables to present the idea of organizational conflicts and employee turnover. The hypotheses were tested using a survey data of 340 questionnaires distributed randomly to employees working in four private hospitals in Jordan. Random selection of private hospitals was made among eight hospitals in the northern governorates of Jordan (Irbid, Jerash, Mafraq, and Ajlun), which are considered the largest districts in the country. The collected data were analyzed using the SPSS program, and initial statistical techniques were applied. The results showed that the highest level of impact of organizational conflicts on the internal turnover of employees was related to the conflict between employees and direct supervisors. However, the highest level of the impact of organizational conflicts on the external turnover of employees was related to the conflict between employees and top management. The low-level job conflicts of employees were those with owners and middle management. Thus, to create stability, prevent work pressure, and retain employees, managers of private hospitals necessarily need to provide an appropriate work environment, develop high level of well-being, and decrease the workload.
AcknowledgmentsWe would like to thank Al-Balqa Applied University in the Kingdom of Jordan and the Institute of Public Administration in the Kingdom of Saudi Arabia for their kind support and for giving us access to the research facilities.
VenaSeal for vertical veno-venous reflux elimination in patients with chronic venous disease
Authors: Belentsov S. M.
Published: June 2021

Introduction. Chronic venous disease significantly reduces quality of life and often leads to complications. The only way to eliminate hemodynamically significant blood flow disorders is the surgical method, incl. its latest modification is the VenaSeal.Objective of the study. To study the immediate and long-term results of the use of VenaSeal adhesive technology to obliterate the incompetent major saphenous veins, as well as the potential benefits in special groups of patients based on three-year experience in using VenaSeal Glue Procedure.Materials and methods. Over a 3-year period, we have treated 104 patients with VenaSeal. The average age was 59.6 ± 14.97 years, the CEAP class was 3.2 ± 1.09. 101 patients had varicose veins, in three cases - post-thrombotic. The intervention was performed on 117 incompetent main veins: GSV – 107, SSV – 10.Results and discussion. Clinical evaluation and ultrasound imaging of veins immediately after the intervention of vein occlusion throughout the intervention. There was no pronounced pain syndrome after surgery. Complications occurred in 3 patients in the form of chemical phlebitis. Long-term results up to 3 years were studied clinically and using ultrasound in 72 patients (76 veins): recanalization was noted in 2 GSV (2.6%), which in one case was accompanied by the formation of a recurrent varicose veins. To study the effect of VenaSeal on the quality of life in a comparative aspect, a non-randomized, single-center, open-label study was carried out; it included patients, incl. with GSV occlusion using RFA and EVLT. In the group of patients after VenaSeal, the quality of life indicators were better values. In addition, the absence of the need for elastic compression made the surgical treatment of patients with chronic venous disease and concomitant lesions of the peripheral arterial bed. In groups of elderly and senile patients, patients with weeping eczema, with obesity, additional advantages were found in the form of a decrease in the invasiveness of the intervention and the possibility of correcting reflux as a hemodynamic basis for the development of trophic disorders with the aim of their faster and more effective relief.Conclusions. Non-thermal obliteration of incompetent major saphenous veins using VenaSeal in varicose veins and post-thrombotic disease is highly effective: the immediate results assessed with clinical methods and using ultrasound duplex scanning confirmed the occlusion of the target vein in all cases. The study of long-term results revealed recanalization of two veins out of 76, which accounted for 2.6%.
A comparative analysis of clinical guidelines in chronic venous diseases
Authors: Zubkov D. S.
Published: June 2021

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Skin bacterial infections – always a topical problem
Authors: Piruzyan A. L. , Niewozinska Z. A. , Korsunskaya I. M.
Published: June 2021

Bacterial skin infections are one of the most common reasons for visiting a dermatologist. A huge number of different microor-ganisms live on the human skin, but sometimes due to some external and internal factors the balance is disturbed, which leads to the predominance of one or more colonies and the subsequent development of the infection. Often staphylococci or streptococci are the cause of pyodermias (this is how skin bacterial infections are usually called). In the treatment of pyodermias, local antibacterial drugs are most often used. But given the free access to antibiotics and their thoughtless use, the sensitivity of many strains of microorganisms to the effects of drugs is reduced, which in many cases makes treatment difficult. According to various data, the sensitivity to fusidic acid remains very high, which makes fusidic acid-based drugs an optimal choice for therapy of bacterial infections. It is worth noting that recent studies have also demonstrated the anti-inflammatory activity of fusidic acid, which has a positive effect on the effectiveness of therapy. In today’s realities, the problem of bacterial skin infections remains as urgent as ever. Prolonged use of personal protective equipment and, in particular, medical masks creates ideal conditions for increased growth of opportunistic microorganisms. In this article, we present a case from our own practice. Impetigo developed in a patient after improper use of personal protective equipment. Fusidic acid topical therapy achieved a good clinical result after only 7 days. Thus, given the prevalence of pyodermias, fusidic acid-based drugs may be the optimal solution to the problem.
Fluticasone propionate for external use: pharmacological properties and clinical effectiveness
Authors: Dvoriankova E. V.
Published: June 2021

Topical corticosteroids are first-line medications in the treatment of an overwhelming number of both acute and chronic inflammatory noninfectious skin diseases. These drugs can be characterized as the drugs of choice in dermatological practice, which is determined by anti-inflammatory, immunosuppressive and antiproliferative effects of corticosteroids. Nevertheless, the use of these drugs in some cases may be limited by the potential risk of adverse side effects, which, in turn, determines a rather widespread corticophobia among patients, as well as among some doctors. In this regard, the current efforts of pharmaceutical companies are focused on the development of topical corticosteroids with the least number of side effects without loss of clinical efficacy. The synthetic carbothioate corticosteroid fluticasone propionate (FP) is a medium strength (class III) synthetic fluorinated corticosteroid for topical treatment of skin conditions. Its molecule has a high degree of lipophilicity, which allows it to be actively absorbed into the skin. The drug has a high affinity to glucocorticoid receptors against the background of the absence of mineralcorticoid activity. In addition, FP is relatively quickly subjected to enzymatic hydrolysis to inactive metabolites. This determines the high clinical efficacy of this drug with minimal risk of both local and systemic adverse events. It is available as cream and ointment with the same efficacy, but with different concentrations (0.05 or 0.005%) of the active substance. This article reviews the pharmacology and safety profile as well as the use of topical FP in clinical practice.
Configuração de mercados étnicos nas dimensões temporal e ambiental: um ensaio teórico sobre negócios de imigrantes brasileiros
Authors: Falcão Roberto Pessoa de Queiroz , Cruz Eduardo Picanço
Published: June 2021

Analisa-se o fenômeno da configuração de mercados de produtos e serviços étnicos dentro das comunidades imigrantes brasileiras estabelecidas no exterior. Por meio de um ensaio teórico, são feitas considerações baseadas em achados de trabalhos anteriores, em evidências empíricas e observações dos autores a respeito das práticas de mercados étnicos, no seio de comunidades brasileiras. O relato e a interpretação dos fatos históricos foram estruturados na forma de análise do tema. Ao final do ensaio teórico são apresentados uma tabela e um diagrama resumo dos achados discutidos. A tabela se refere às práticas de transações, gerando cocriação de valor, práticas normativas e práticas representacionais baseadas nas evidências empíricas. Já o diagrama ilustra a configuração de mercados étnicos no sentido temporal e ambiental, identificando fatores internos da comunidade ou do ambiente que seriam facilitadores da criação de mercados.
Cardiovascular adverse effects of lopinavir/ritonavir and hydroxychloroquine in COVID-19 patients: Cases from a single pharmacovigilance centre
Authors: Istampoulouoglou Ioanna , Zimmermanns Barbara , Grandinetti Tanja , Marzolini Catia , Harings-Kaim Annette , Koechlin-Lemke Sarah , Scholz Irene , Bassetti Stefano , Leuppi-Taegtmeyer Anne B
Published: June 2021

In this article we summarize the cardiovascular adverse events that were observed in three patients during their treatment for COVID-19 and discuss their association with lopinavir/ritonavir (LPV/r) and hydroxychloroquine (HCQ). The cases were reported to our regional pharmacovigilance centre in April 2020. All three patients were above 75 years in age, male and multimorbid, and had been hospitalized for treatment of COVID-19. As part of their treatment, all of them received a very strictly monitored off-label therapy with LPV/r and HCQ, for which they had given their prior, written, informed consent. In one patient, erythromycin was also administered. All three patients developed a significant QTc time prolongation during or shortly after therapy with the above drugs. On account of this, the treatment had to be discontinued early in each case and QTc time recovered in all three patients.
Baza noclegowa i towarzysząca – wybrane elementy infrastruktury polskich parków narodowych w latach 2005‒2015
Authors: Bera Milena , Zaremba Aneta
Published: June 2021

Parki narodowe są obszarem bardzo atrakcyjnym turystycznie. Corocznie przybywają tam miliony turystów, a ich liczba ciągle rośnie. Powoduje to wiele problemów w zarządzaniu obszarem chronionym. Stąd też istotne jest zapewnienie odpowiedniej infrastruktury oraz przygotowanie tras turystycznych na tych obszarach tak, aby jak najmniej szkodzić przyrodzie. Celem artykułu jest charakterystyka i ocena zagospodarowania turystycznego i rekreacyjnego parków narodowych w Polsce w latach 2005–2015. Na podstawie zgromadzonych danych empirycznych pochodzących z Głównego Urzędu Statystycznego dokonano porównania wybranych elementów wpływających na zagospodarowanie i przystosowanie danego obszaru parku narodowego do ruchu turystycznego, głównie bazy noclegowej i towarzyszącej. Analiza porównawcza wykazała zróżnicowanie badanych parków w omawianym zakresie. Z przeprowadzonych badań wynika, że największy udział w bazie noclegowej w parkach narodowych miały kempingi i biwaki, z zauważalną tendencją spadkową w każdym analizowanym roku. Liczba ośrodków i domów wczasowych również uległa nieznacznemu zmniejszeniu. Ponadto, w latach 2005–2015 zauważa się tendencję wzrostową w gęstości i długości szlaków, długości nartostrad i schronów przeciwdeszczowych.
Manoel de Barros e a poética do rewind
Authors: Lino Patrícia
Published: June 2021

In order to contest the superiority of the colonizer’s language and cosmovision, Manoel de Barros builds, especially starting from Compêndio para Uso dos Pássaros (1960), a series of micro-cosmogonies or micro-universes. The contiguous elaboration of these universes represents, I argue, a direct response to the erasure by European colonization of wild, unextracted, Amerindian universes. Manoel’s timeless poetic word portrays an anarchic vision of humans, animals, vegetal world that exists in an original, untouched, and imaginary space. This space, however, is modeled on an imposed colonial language built or premised on the irrecoverable loss of the past and is manifested through the plurality of mediums of expression (alphabetical, visual, and performative), as well as recourse to humor, and a confrontation with the insufficiency of Latin alphabet. The narration imparted by Manoel of several vestiges of the world not only challenges the Western account of logocentric knowledge, but also invites the reader to understand that no one cosmogonic and cosmologic rendition is truer or more valid than any of the others. The return to this plurality of beginnings materializes itself in Manoel’s interest for drawing as well as in the way Manoel explores and reinvents the use of footnotes on the page.
Транспортные и морфологические характеристики тонких пленок YBa-=SUB=-2-=/SUB=-Cu-=SUB=-3-=/SUB=-O-=SUB=-7-x-=/SUB=- при импульсном лазерном напылении со скоростной фильтрацией лазерного эрозионного факела
Authors: Ильин А.И. , Иванов А.А.
Published: June 2021

Режимы импульсного лазерного напыления со скоростной фильтрацией эрозионного факела с частотой 4-33 Hz при разном времени осаждения на подложки SrTiO3(100) при 730-750oC, скорости отфильтрованных частиц применили для изменения характеристик зависимости R (T) пленок YBa2Cu3O7-x толщиной 150-200 nm. Осаждение при скоростях фильтрации лазерного факела ~ 30 Hz формировало ровную поверхность с сопротивлением при комнатной температуре в 2 раза большим, чем в пленках, полученных без фильтрации, что предполагало отсутствие путей легкого транспорта дырок в плоскости "ab". Ширина сверхпроводящего перехода Delta T составила 2.5-2.9 K, а T(R=0) до 85.8 K при кислородном индексе y=6.85, соответствующем характеристикам хороших пленок такой толщины. Кислородный индекс в пленках был выше (6.85-7.04) и ниже (6.85-6.8) при частоте фильтрации 18-4.5 Hz и 21-33 Hz, соответственно. Исследования поверхности методами сканирующей электронной микроскопии позволили обнаружить перестройку кристаллической структуры при осаждении и ее влияние на транспортные характеристики пленок. Ключевые слова: импульсное лазерное осаждение, рельеф поверхности, транспортные характеристики пленок, эволюция пленки, SrTiO3.
Создание тонких пленок NbN при комнатной температуре подложки
Authors: Гурович Б.А. , Гончаров Б.В. , Приходько К.Е. , Кутузов Л.В. , Столяров Л.В. , Малиева Е.М.
Published: June 2021

Thin NbN films were prepared by magnetron sputtering. The films were prepared on sapphire substrates at temperatures of 20–300 ° C. Superconducting transition temperature for different samples, depending on the substrate temperature during deposition was 8–14 K. The density of the critical current jc lies in the range of 0.8−8 MA / cm2, which allows the usage of these films for creation of multilayer structures, due to the absence of annealing, to which each underlying layer with structures is exposed when sputtered next.
Factors Influencing General Practitioners’ Intention to Utilize Wearable ECG Devices for Atrial Fibrillation Screening: An Acceptance Model and Questionnaire Survey (Preprint)
Authors: Yao Yi , Li Zhichao , He Yi , Zhang Yalin , Guo Zhaoxia , Lei Yi , Zhao Qian , LI Dongze , Zhang Zhi , Zhang Yonggang , Liao Xiaoyang
Published: June 2021

BACKGROUND

Atrial fibrillation (AF) was a challenging cardiovascular disease worldwide. Wearable electrocardiograph devices (WEDs) had great potential to improve the detection rate of AF in primary care. However, the factors that influence general practitioners’ (GPs) acceptance of WEDs were not well understood.

OBJECTIVE

To identify factors that influenced the intention of GPs to utilize WEDs in their practice to screen patients for AF.

METHODS

The research hypotheses and questionnaire items were designed and developed based on the extended unified theory of acceptance and technology (UTAUT) framework. We used stratified random sampling and obtained the data through an online survey. We used structural equation modeling(SMR) to analyze the collected data .

RESULTS

A total of 1004 valid questionnaires from GPs across Sichuan province in China were collected. Three factors increased GPs' intention to utilize WEDs to screen patients for AF, including performance expectancy (β=0.121, P=0.004), social influence (β=0.356, P<0.001), and price perception (β=0.587, P<0.001). Perception risk (β=-0.059, P<0.001) decreased usage intention, while effort expectancy (β=-0.079, P=0.155) and facilitating conditions (β=-0.014, P=0.868) did not affect usage intention. Gender (β=-0.022, P=0.179), age (β=0.006, P=0.699), education level (β=-0.22, P=0.184) and training (β=0.007, P=0.69) were not significantly correlated with usage intention, and these four factors had no moderating effect on the path coefficients.

CONCLUSIONS

GPs’ intention to utilize WEDs is affected by performance expectancy, price perception, perception risk and social influence. Health information technology companies should improve the usability of WEDs and carry out studies to provide evidence for the security of such devices. They should also focus on social influence and provide the devices at a reasonable price. The findings of this study point to a new option for GPs to screen patients for AF.

CLINICALTRIAL

This study is registered at www.chictr.org.cn (Identifier: CHiCTR1900021246).
eSurgery - Digital Transformation in Surgery, Surgical Edu-cation and Training: Survey Analysis of the Status Quo in Germany. (Preprint)
Authors: Kröplin Juliane , Huber Tobias , Geis Christian , Braun Benedikt , Fritz Tobias
Published: June 2021

UNSTRUCTURED

Objective
In surgery electronic healthcare systems offer numerous options to improve patient care. Aim of this study was to analyse the current status of digitalisation and its influence in surgery, with a special focus on surgical education and training.

Methods
An individually created questionnaire was used to analyse the subjective assessment of the digitalisation processes in clinical surgery. The online questionnaire consisted of 16 questions regarding the importance and the corresponding implementation of the teaching contents: big data, health apps, messenger apps, telemedicine, data protection/IT security, ethics, simulator training, economics and e-learning were included. The participation link was sent to members of the German Society of Surgery via the e-mail distribution list.

Results
In total, 119 surgeons (response rate = 19.8 %) took part in the survey. 18.5 % of them were trainees (TR). 81.5 % had already completed specialist training (SP). 66.4 % confirm a positive influence of digitalisation on the quality of patient care. The presence of a surgical robot was confirmed by 47.9 % of the participants. 22.0 % (n=26) of the participants confirm the possibil-ity of using virtual simulators. According to 79.0 % of the participants, the integration of digital technologies in surgical education for basic and advanced stage surgeons should be aimed for. Data protection (1.7) and e-Learning (1.7) were rated as the most important teaching content. The greatest discrepancy between importance and implementation was seen in the teaching content of big data (mean: 2.2 to 3.8).

Conclusion
The results of the survey reveal the particular importance of digitalisation content for surgery, surgical education and training. At the same time, the results underline the desire for in-creased integration of digital competence teaching. The data also show an overall more pro-gressive and optimistic perception of TR. In order to meet the challenges of the digital trans-formation, the implementation of suitable curricula, including virtual simulation-based training and blended-learning teaching concepts should be emphasized.