bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Teknik Relaksasi Napas dalam Terhadap Tingkat Kecemasan Mahasiswa Semester II dalam Menghadapi Ujian Akhir Semester di Akademi Perawatan RS PGI Cikini
Authors: Verawaty Kessy , Widiastuti Sri Hunun
Published: March 2022

Kecemasan merupakaan suatu respons individu terhadap suatu keadaan yang tidak menyenangkan dan dialami oleh semua makhluk hidup. Ujian akhir semester (UAS) adalah alat evaluatif dalam kegiatan belajar mengajar. Situasi tersebut dapat menimbulkan kecemasan pada mahasiswa. Tujuan penelitian ini untuk mengetahui pengaruh Teknik Relaksasi Napas Dalam terhadap tingkat kecemasan mahasiswa semester II dalam menghadapi ujian akhir semester di Akademi Perawatan RS PGI Cikini. Jumlah responden sejumlah 43 orang mahasiswa dalam satu kelompok yang memenuhi kriteria inklusi dan dilakukan pengisian kuesioner Skala HARS (Hamilton Anxiety Rating Scale) penelitian ini dilakukan pada 02 Juli 2018 di Akademi Perawatan RS PGI Cikini. Metode yang digunakan secara kuantitatif  Pra experiment yaitu rancangan penelitian yang mencakup satu kelompok perlakuan pada tahap pre test yang kemudian dilanjutkan dengan tindakan dan post test. Hasil penelitian menunjukkan bahwa sebelum dilakukan Tindakan Teknik Relaksasi Napas Dalam responden yang tidak mengalami kecemasan (25,6%) dalam menghadapi ujian akhir semester, setelah diberikan tindakan Teknik Relaksasi Napas Dalam mengalami peningkatan jumlah mahasiswa yang tidak mengalami kecemasan (58,1%). Sementara bersamaan dengan itu terjadi penurunan tingkat kecemasan sedang (20,9%) dan (100%) penurunan tingkat kecemasan berat. Hasil analisis Independent Samples Test diperoleh tingkat signifikansi p = 0,000 < 0,05, yang berarti secara statistik Teknik Relaksasi Napas Dalam berpengaruh untuk menurunkan tingkat kecemasan mahasiswa dalam menghadapi ujian akhir semester.
CAN THE KANGURU MOTHER CARE (KMC) INTERVENTION IMPROVE BREAST MILK PRODUCTION?
Authors: Nia Ayuda
Published: March 2022

Introduction: Babies who are hospitalized can be one of the factors causing stress for mothers because they have to be temporarily separated from the baby. Stress in mothers with these conditions can be affect breast milk production (ASI), meanwhile breast milk is very necessary for optimal baby growth and development. The purpose of this study was to identify the effect of the implementation kangaroo mother care (KMC) on increased milk production as long as the baby was hospitalized. Methods: The design of this study is qualitative with multiple case design involving three selected cases and has predefined inclusion criteria. The research was conducted from January to March 2016 at RSUPN Ciptomangunkusumo and RSAB Harapan Kita. Breast milk production was measure during the mother carrying out KMC for 3 days using an electric pump or marmet technique. Result: Furthermore, the results of expressed breast milk are recorded on the sheet provided. The results showed that there was an increase in milk production for 3 days with an average increase in milk production of 16,67-43,33 ml/day. Conclusion: KMC has a positive impact on milk production and volume, especially if the mother frequently implements PMK, so this intervention can support mothers who complain of low milk production.
Tingkat Pertumbuhan dan Perkembangan Anak Usia Toddler di Paud Santa Maria Monica Bekasi Timur
Authors: Natasha Prasma Eva , Siringoringo Lince , Hunun Widiastuti Sri , Butarbutar Samsinar
Published: March 2022

Usia 1-3 tahun (toddler) merupakan usia emas (golden age) dimana pertumbuhan dan perkembangan berlangsung cepat dalam segala aspek. Tingkat pertumbuhan dan perkembangan perlu dideteksi  sejak dini agar dapat diketahui dan ditangani sejak dini adanya kelainan dalam pertumbuhan dan perkembangan pada anak. Tujuan penelitian ini adalah untuk mengetahui tingkat pertumbuhan dan perkembangan anak serta mendeteksi sejak dini adanya kelainan pertumbuhan dan perkembangan. Desain penelitian yang digunakan dalam penelitian ini adalah penelitian deskriptif cross sectional. Populasi dalam penelitian ini adalah anak usia 1-3 tahun (toddler) di PAUD Santa Maria Monica Bekasi Timur sebanyak 40 orang. Hasil dari 40 orang responden yang diteliti menunjukkan  95% anak dengan gizi normal, 75% pertumbuhan tinggi badan  sesuai usia, 100% lingkar kepala normal. Hasil penelitian terhadap tingkat perkembangan menunjukkan  90% perkembangan anak sesuai usia, 100% normal untuk Tes Daya Lihat dan Tes Daya Dengar. Hasil penelitian terhadap perilaku emosional menunjukkan 100% anak tidak mengalami masalah terhadap perilaku emosional. Kesimpulan dari penelitian ini adalah sebagian besar anak usia 1-3 tahun  (toddler) di PAUD Santa Maria Monica Bekasi Timur mengalami pertumbuhan dan perkembangan  yang normal sesuai usia.
Religiositas dan Perilaku Caring Perawat dan Bidan di Wilayah Indonesia Tengah
Authors: Pratiwi Dayning Tyas , Marbun Ester Collin , Zai Octavinny Christiani , Juniarta Juniarta , Lebdawicaksaputri Kinanthi
Published: March 2022

Religiositas perawat dan bidan dapat membentuk perilaku caring mereka. Perilaku caring dapat terlihat saat memberikan perhatian melalui sikap, rasa peduli, hormat dan menghargai kepada seseorang. Tujuan penelitian ini adalah untuk mengetahui hubungan antara religiositas dengan perilaku caring perawat dan bidan. Metode yang digunakan adalah deskriptif korelasional dengan populasi berjumlah 127 orang yaitu perawat dan bidan dengan latar belakang agama Kristen dan Katolik yang bekerja di satu rumah sakit swasta di Indonesia tengah. Teknik convinience sampling digunakan dengan jumlah sampel yang didapatkan sebanyak 89 orang. Dua kuesioner versi bahasa Indonesia digunakan yaitu The Four Basic Dimensions of Religiousness Scale  (4BDRS) untuk mengukur religiositas (Cronbach’s Alpha 0,89) dan kuesioner penelitian mengenai perilaku caring mengacu pada Teori Swanson (Cronbach’s Alpha 0,891). Hasil penelitian menunjukkan tidak ada hubungan antara religiositas dan perilaku caring perawat dan bidan di Indonesia Tengah (p value=0.47). Penelitian selanjutnya diharapkan dapat mengembangkan berbagai lokasi dan karakteristik responden penelitian sehingga dapat tergambar hubungan antara religiositas dan perilaku caring perawat dan bidan di Indonesia.
Kualitas Hidup Pasien dengan Penyakit Ginjal Kronis dengan Terapi Hemodialisa di RS PGI Cikini
Authors: Irene Indri , Yemina Loritta , Pangaribuan Santa Maria
Published: March 2022

Penyakit ginjal kronik merupakan penyakit ginjal tahap akhir yang disebabkan oleh hilangnya fungsi tubuh untuk mempertahankan metabolisme dan keseimbangan cairan, elektrolit sehingga mengakibatkan tingginya kadar ureum dalam darah yang membutuhkan terapi hemodialisa akan berdampak pada kualitas hidup pasien ginjal kronik. Kualitas hidup yang baik akan memberikan manfaat positif bagi individu. Individu dengan kualitas hidup yang baik akan merasa bahagia, terus mampu mempertahankan keberlangsungan hidup, serta mampu berkontribusi kepada sesuatu yang lebih luas di luar diri. Tujuan penelitian ini untuk mengetahui gambaran kualitas hidup pasien ginjal kronik dengan terapi hemodialisa di Rumah Sakit PGI Cikini. Metode penelitian ini menggunakan jenis penelitian deskritif. populasi dan sampel menggunakan rumus slovin yang berjumlah 47 responden. Pengumpulan data menggunakan skala kualitas hidup dari Word Health Organization Quality Of Life (WHOQOL-BREF) yang berisi 26 item pertanyaan meliputi domain fisik, psikologis, lingkungan dan sosial. Analisis data menggunakan uji univariat dalam bentuk distribusi frekuensi. Hasil menunjukan didapatkan kualitas hidup pasien ginjal kronik dilihat dari dimensi kesehatan fisik dan psikologis termasuk pada katagori sedang, sedangkan untuk domain lingkungan dan sosial pada katagori baik. Kesimpulan kualitas hidup merupakan indikator penting untuk di teliti
Perilaku Sosial Masyarakat Desa Kapringan terhadap Pelaksanaan Unjungan
Authors: A Muasromatul
Published: March 2022

Abstrak

Penelitian ini berjudul Perilaku sosial masyarakat desa kapringan terhadap pelaksanaan upacara adat unjungan. Untuk menggali data, digunakan metode penelitian etnografi dengan pendekatan kualitatif. Temuan hasil penelitian menunjukan bahwa terdapat adanya perbedaan terhadap pelaksanaan upacara adat unjungan di desa kapringan dengan desa lain, hal tersebut dapat terlihat dari tatacara pelaksanaanya, jika di desa lain unjungan hanya dilaksanakan di satu sampai dua tempat saja, namun di desa Kapringan bisa lebih dari itu, karena memiliki banyak sekali ki buyut sehingga waktu pelaksanaannya lebih dari satu bulan dalam setiap tahunnya, di awali dari unjungan buyut Pringgabaya diakhiri dengan unjungan buyut Disa. Dari perbedaan tersebut, ternyata terdapat beberapa prilaku sosial yang menyimpang pada masyarakat desa kapringan ketika pelaksanaan upacara adat unjungan berlangsung  hal tersebut sangat berbenturan dengan makna dari upacara adat unjungan itu sendiri.
Analisis Kestabilan Model SITR pada Penyebaran Penyakit Hepatitis A dengan Vaksinasi
Authors: Sidik Amelia Tri Rahma , Sari Lia Nanda , Ismail Apon
Published: March 2022

In this article, the SITR Model for the spread of Hepatitis A by Vaccination is discussed. This study aims to analyze the stability of the model for the spread of hepatitis A disease around the points, interpret the model that has been formed by performing numerical simulations, and determine the effect of vaccination and treatment on the human population infected with hepatitis A. indicated by (T1) is stable and the endemic fixed point indicated by (T2) is stable. Based on the simulation obtained from each class (S, I, T, R) for R0<1, it shows that the population dynamics is (0.13,0,0,0.87) of the total population. Meanwhile, for R0>1 with a basic reproduction number, it shows the population dynamics of each class (S, I, T, R) that is (0.12,0.0056,0.0053,0.85) of the total population.
Penjadwalan Mata Pelajaran Menggunakan Integer Nonlinear Programming
Authors: Mile Abdul Rasyid , Katili Muhammad Rifai , Nurwan Nurwan
Published: March 2022

Timetabling is one of the problems faced by large numbers of institutions, including schools. In this paper, this timetabling problem is mathematically modeled using Integer Nonlinear Programming to optimize the result with the non-linear objective function or constraint function. The model was implemented to solve the timetabling problem in one of Madrasah Tsanawiyah Islamic junior high school in Gorontalo. The result effective solutions in the form of subject and instructor timetabling that overcome the obstacles are obtained. To better the timetabling, supplementary teachers are still required for some subjects.
Model Integer Linear Programming pada Optimisasi Distribusi Logistik di Daerah Bencana
Authors: Kasim Miranti H. , Djakaria Ismail , Yahya Lailany
Published: March 2022

Logistics distribution in disaster-affected areas includes the delivery of relief goods (food, medicine, and clothing) using three types of vehicles with different carrying capacities for each vehicle. In distributing relief goods, unfulfilled requests can occur in disaster-affected areas. This problem can be modeled in the form of integer linear programming because there is a variable that must be an integer value to minimize unfulfilled demand for all types of relief goods at each point of demand. The branch and bound method can solve this problem's integer linear programming model. The next model is simulated using the LINGO 11.0 programming language. The simulation results show that the system can be considered feasible to use. Thus, the vehicle allocation is also obtained in each period with distribution costs from the point of supply to the point of demand. This distribution process lasts for four periods by showing a change in the number of unfulfilled requests. In the last period, there was no more unfulfilled demand for aid to obtain optimal results.
comparison behaviors of some scintillators for radiation shielding
Authors: Ravangvong Sunantasak , Sriwongsa Kittisak , Glumglomchit Punsak , Janthimangkul Ratchanon , Pansuay Maysinee , Puangfuang Salinya , Suksee Nopparat , Khobkham Chumphon
Published: March 2022

In this research, the photon interaction of NaI:Tl, LiI:Tl and CsI:Tl scintillators have been comparative studied. The photon interaction effectiveness of scintillators was investigated by determine mass attenuation coefficient (m) and half value layer (HVL) at photon energy ranging 1 keV – 100 GeV using WinXCom computer software program. Build–up factors were computed by Geometric Progression (G–P) fitting formula at energy ranging 15 keV – 15 MeV up to 40 mfp penetration depth. The result shown that, CsI:Tl scintillator was excellent at interacting with photons. This study indicated that CsI:Tl can be developed for radiation detectors and sensors.
Taxonomic analysis of the spatial differentiation of purchase prices on the fruit and vegetable market in Poland
Authors: Kubala Sebastian
Published: March 2022

Aim: The main aim of the article is to separate groups of voivodships that in 2018 are characterized by a similar level of purchase prices on the vegetable and fruit market. In addition, a comparative study between the markets in question was made for the results obtained.
Material and methods: The agglomeration method was used for the study. The subject of the study were individual Polish voivodships in 2018. Six variables characterizing purchase prices of vegetables and fruit were taken into account.
Results and conclusions: The achieved research results have shown that in Poland there is a significant variation in purchase prices on the vegetable and fruit market. A comparative study of clusters of voivodships with a similar level of purchase prices between the vegetable and fruit market, it should be stated that there are no significant similarities in this respect.
Selected legal issues related to agricultural real estate during the COVID-19 pandemic
Authors: Suchoń Aneta
Published: March 2022

The aim of the article was to determine whether, during the COVID-19 pandemic, the provisions on agricultural real estate, including those contained in the Act of April 11, 2003 on shaping the agricultural system (hereinafter UKUR), matched the socio-economic needs. Secondly, whether and to what extent agricultural producers running agricultural activity on agricultural real estate obtained additional aid due to the epidemic. First, the considerations focus on the acquisition of agricultural real estate with an area of up to 1 ha and often used for the construction of a house with a home garden. Reference is also made to the statistical data on the exercise of the pre-emption right and the acquisition by the National Center for Agricultural Support. Subsequently, the issue of ensuring food and food security in times of the pandemic is indicated to be of greater importance in the context of the obligations of the owners of agricultural real estate, including running a farm for 5 to 15 years after its acquisition. Next, the considerations focus on state support for agricultural producers during the COVID-19 pandemic, referring to lease tenders conducted by the National Center for Agricultural Support, the rules for paying tax, EU aid and benefits granted to agricultural producers in relation to the COVID-19 pandemic. Finally, the problem of making investments in renewable energy on agricultural land and concluded lease agreements is discussed.
The effects of the assignment of future rent claims by the entity against which the restructuring proceedings were subsequently opened
Authors: Frosztęga Norbert , Woźniak Hubert
Published: March 2022

In the theory of law and the jurisprudence of courts, there is a dispute as to when and in whose property there is a disputable effect of making the assignment of future rent claims. Three concepts presented by theoreticians of civil law lead to different legal consequences. The practical importance of the above dispute has far-reaching effects under the restructuring law in the event that the restructuring proceedings were subsequently opened against the assignor.
From the perspective of Polish private law, the theory of the pass-through acquisition of claims is more convincing, what in the event of the subsequent opening of restructuring proceedings against the assignor, that the claims arising after the arrangement date are included in the arrangement/remedial estate. The adoption of a different concept may justify the examination of the assignment of future claims from the perspective of ineffectiveness against the arrangement/remedial estate.
Społeczna odpowiedzialność biznesu w Polsce w świetle celów zrównoważonego rozwoju
Authors: Firlej Krzysztof Adam
Published: March 2022

Cel pracy: jest nim określenie znaczenia działań społecznie odpowiedzialnych przedsiębiorstw dla realizacji celów zrównoważonego rozwoju w Polsce. W badaniach posłużono się metodą desk research. Warstwa teoretyczna pracy została przygotowana na podstawie kwerendy literatury przedmiotu. Warstwa empiryczna pracy została zredagowana w oparciu analizę danych empi-rycznych dotyczących aktywności polskich przedsiębiorstw w obszarach społecznej odpowie-dzialności biznesu.
Baza danych: Dane empiryczne wykorzystane w badaniu zostały zaczerpnięte z cyklu publi-kacji „Raport Odpowiedzialny biznes w Polsce. Dobre Praktyki…”, który zawiera informacje na temat przedsiębiorstw angażujących się w największym stopniu w działania społecznie od-powiedzialne w Polsce.
Wynik i wnioski: W latach 2016-2020 liczba praktyk nowych, praktyk długoletnich oraz firm zaangażowanych we wszystkich obszarach społecznej odpowiedzialności biznesu zwiększyła się w każdym przypadku od kilkudziesięciu do kilkuset procent. Świadczy to jednoznacznie o wzroście świadomości właścicieli przedsiębiorstw, którzy zauważają, że oprócz chęci genero-wania zysków znaczenie ma także troska o dobrostan otoczenia wewnętrznego i zewnętrznego firmy. Potwierdzono tezę, że rośnie popularność podejmowania dobrych praktyk w ramach społecznej odpowiedzialności biznesu co znajduje odzwierciedlenie w szerszej realizacji celów zrównoważonego rozwoju.
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Abstract
The aim of the study is to determine the importance of activities of socially responsible enter-prises for the implementation of sustainable development goals in Poland. The research used the desk research method. The theoretical layer of the thesis was prepared on the basis of a query of the literature on the subject. The empirical layer of the work was edited on the basis of an analysis of empirical data on the activity of Polish enterprises in the areas of corporate social responsibility. The empirical data used in the study was taken from the series of publica-tions entitled "Report Responsible business in Poland. Good Practices ... ”which contains in-formation on enterprises engaging to the greatest extent in socially responsible activities in Poland. In the years 2016-2020, the number of new practices, long-term practices and compa-nies involved in all areas of corporate social responsibility increased in each case from several dozen to several hundred percent. This clearly proves the growing awareness of business ow-ners who notice that apart from the will to generate profits, it is also important to care for the well-being of the internal and external environment of the company. The thesis was confirmed that the popularity of taking good practices as part of corporate social responsibility is gro-wing, which is reflected in the wider implementation of the goals of sustainable development.
Between Outcomes and Processes: Revisiting the Discourse on Corporate Social Responsibility Impacts
Authors: Tapfuma Muruviwa Addmore , Akpan Wilson , Hastings Nekhwevha Fhulufhuwani , Godfrey Tshabalala Nono
Published: March 2022

For so long the corporate social responsibility agenda has centrally focused on impacts and outcomes at the expense of CSR processes. This paper argues for a discourse and practice of CSR that brings into clearer focus CSR processes. The central aim is to understand how CSR processes inform, direct and shape CSR outcomes within a community development context. The study was carried out in Mhondoro-Ngezi, Zimbabwe which is in a rural setting. The study employed a triangulated design, with data collected using a mini survey, focus groups and in-depth interviews. The key findings are that the Zimbabwean mining giant, Zimplats, dominates and controls all CSR processes such as decision making, stakeholder engagement such that it limits the involvement of community members in CSR projects. This paper acknowledges the need for a radical approach in the analysis of CSR by diverting from an “outcomes oriented CSR agenda” to a “process led CSR agenda”. The analysis of CSR processes in Mhondoro-Ngezi showed that, power is a decorated asset in which stakeholders use to control the CSR processes to achieve certain outcomes.
The Effects of Multivitamin Use in Pregnancy on Mother and Fetus Health
Authors: Taner Neda , Zehra Omurtag Gülden
Published: March 2022

Pregnancy and birth method are the key factors to boost healthy new generations. Pregnancy may be a special period during which ladies have lived several process. During this period, for the protection of maternal and fetus health enhanced energy and nutrition demand supply is needed. Sufficient intake of nutrients and correct weight gain has necessary effects on each the mother’s and the developing fetal health. it’s also important to guard against short and long run complications. Nutrition is very important before and once pregnancy yet as throughout pregnancy. During this study, the intake of macro and micro nutrient items moving maternal and ve fetal health issues absolutely during pregnancy is detailed. As macro nutrition items carbohydrate, protein and fat examined. Adequate protein is important during pregnancy. Fats are important nutrients that provide essential fatty acids for the development of the brain and central nervous system of the fetus. Micro nutrition items water soluble and oil soluble as 2 cluster examined. The consequences of minerals during pregnancy were also examined.
Predicción de las fuerzas musculares de miembro superior durante los movimientos de flexión - extensión y pronación - supinación a partir de un modelo biomecánico desarrollado en la plataforma Opensim
Authors: Uribe Acosta Natali , Díaz León Christian , Zapata Torres Edison
Published: March 2022

Con el fin de predecir las fuerzas musculares del miembro superior durante cuatro movimientos (flexión – extensión, pronación – supinación), se desarrolla un modelo cinemático y dinámico en una plataforma de libre acceso (Opensim Biomechanics) que permite movimientos de la articulación del hombro, codo y muñeca. El modelo permite hallar las fuerzas de los principales actuadores musculares durante una trayectoria dada. Un modelo principal (genérico) fue escalado para generar una muestra de 35 sujetos. 30 sujetos se obtuvieron por el denominado escalado manual, basado en factores antropométricos y disponible directamente desde Opensim. Cinco sujetos más se obtuvieron por el denominado escalado por marcadores, basado en trayectorias de análisis de movimiento obtenidas a partir de laboratorio de análisis de movimiento y exportadas a Opensim. Haciendo uso de las diferentes herramientas de análisis presentes en la plataforma Opensim y de diversos scripts creados en paralelo, ha sido posible generar modelos de los mencionados movimientos para estimar los rangos de fuerzas de los principales actuadores musculares. Se encontró que las fuerzas musculares durante la flexión y extensión variaron entre 400N y 1000N, para los movimientos de pronación y supinación las fuerzas musculares variaron entre 200N y 400N.
Impact of Early Fortification in Very Low Birth Weight Infants on the Incidence of Malnutrition During a Trophamine Shortage
Authors: Hemmann Brianna , Josephsen Justin , Hillman Noah , Chrivia Rita , Buchanan Paula , Williams Howard , Burleyson Nikki
Published: March 2022

OBJECTIVE

The devastation of pharmaceutical production facilities from Hurricane Maria caused a national shortage of parenteral amino acids in October 2017. Our institution decreased trophamine in very low birth weight (VLBW) infants and initiated human milk fortification at a lower feeding volume to increase enteral protein intake more quickly. The objective of this study was to assess how protein management during the shortage period affected the incidence of malnutrition.

METHODS

This was a retrospective cohort study of infants admitted to 2 neonatal intensive care units from June 1, 2017 to May 31, 2018. Infants between 23 and 32 weeks' gestation were included in this study. The primary outcome was the incidence of malnutrition at 14 days, defined as a z score decline of ≥0.8 SDs, in the pre-shortage period compared with the shortage period. Clinical data regarding adverse effects associated with early fortification and pharmacy costs were recorded.

RESULTS

There were 68 infants prior to and 65 during the shortage who met inclusion criteria. There was no difference in malnutrition between the pre-shortage and shortage groups; however, a significant increase in malnutrition was observed in infants who did not receive early fortification during the shortage. No difference in time to full enteral feeds or necrotizing enterocolitis was observed with early fortification.

CONCLUSIONS

Early fortification in VLBW infants receiving less trophamine during the shortage was not associated with an increase in malnutrition. Restricting trophamine in neonates during the shortage allowed for distribution to other critically ill patients.
Adherence to a Pediatric Continuous Infusion Propofol Policy for Sedation in Mechanically Ventilated Patients: Opportunities for Change and Improvement
Authors: Martin Ashley M. , Tribuzi Andrea , Schieber Maggie L. , Reiter Pamela D.
Published: March 2022

OBJECTIVE

To evaluate adherence to an institutional continuous infusion propofol policy for sedation in mechanically ventilated patients, investigate the rate of propofol-related infusion syndrome (PRIS), and explore areas of improvement to enhance policy compliance and safety.

METHODS

This was a single center, retrospective chart review of patients admitted to a pediatric or cardiac intensive care unit within a large free-standing quaternary care pediatric hospital who received continuous propofol for non-procedural continuous sedation for at least 6 hours between 2014 and 2019. Propofol exposure (dose and duration), laboratory data, and hemodynamic outcomes of patients were evaluated.

RESULTS

A total of 104 patients (108 admissions and 133 treatment courses) met inclusion criteria. Policy adherence to propofol dosing and duration limitations were 70% (93/133 courses) and 68% (91/133 courses), respectively. Adherence to all elements of laboratory and hemodynamic monitoring was 23%. Hypotension and bradycardia were common among patients during propofol treatment courses. Except for hypertriglyceridemia, no significant difference in specific laboratory values were detected between patients exposed to greater than 66 mcg/kg/min (4 mg/kg/hr), compared with those exposed to less than 66 mcg/kg/min of propofol. Patients receiving therapy for longer than 48 hours had the highest rates of laboratory values associated with PRIS. No patient in the study cohort met full criteria for PRIS.

CONCLUSIONS

Adherence to elements of an institutional propofol policy was variable. Improvements in policy adherence may be enhanced by updating policy features, leveraging the electronic medical record order-set, and gaining consensus among key stakeholders.
Capacity Models and Transmission Risk Mitigation: An Engineering
Framework to Predict the Effect of Air Disinfection by Germicidal Ultraviolet
Radiation
Authors: Sarcia Sam Rhea
Published: March 2022

A first-principles–based model for predicting the effect of germicidal radiation
interventions for air disinfection is presented. Calculation of the “capacity” of an
intervention expressed in volumetric flow rate allows for a direct comparison against
fresh-air dilution ventilation and filtration systems, which are quantified in terms of
the clean air provided. A closed-form expression to predict the combined quantitative
impact of spatial gradients and mixing currents on the efficiency with which an
intervention is applied is introduced. If validated, this would allow for systems to be
selected and sized based on simple metrics across a broad range of settings and
applications. The expressions developed are compared against available experimental data
sets, and future validation efforts are proposed. Additionally, a method to identify an
optimal operating capacity for a given setting by comparing costs associated with
disease transmission against the cost of capacity is derived using the Wells-Riley
equation and presented as an appendix.
Jak mierzyć postępy transformacji energetycznej?
Authors: Kopeć Sławomir , Lach Łukasz
Published: March 2022

Celem artykułu jest przybliżenie koncepcji pomiaru postępu transformacji energetycznej z wykorzystaniem wskaźników kompozytowych. W pierwszej części pracy przedstawiono sposób konstrukcji i opisano własności dwóch popularnych kompozytowych wskaźników transformacji energetycznej publikowanych odpowiednio przez Światowe Forum Ekonomiczne (indeks ETI) i Światową Radę Energetyczną (indeks WETI). W drugiej części pracy przedstawiono autorską koncepcję wyznaczania zmodyfikowanego indeksu ETI (indeks METI) wykorzystującą zaawansowany aparat statystyczny zapewniający minimalizację wpływu uznaniowości w procesie konstrukcji wskaźnika kompozytowego. Proponowaną metodykę METI zastosowano do „przeliczenia” wyników indeksu ETI dla roku 2020. Uzyskane rezultaty znacznie różnią się od „oryginalnego” rankingu ETI, w szczególności co do pozycji Polski. W ostatniej części artykułu omówiono możliwe kierunki dalszych prac i zarysowano główne rekomendacje w zakresie możliwości stosowania zmodyfikowanych wskaźników kompozytowych do oceny postępu transformacji energetycznej w Polsce.
Transformacja polskiego systemu elektroenergetycznego i szczególna rola ciepłownictwa i kogeneracji w tym procesie
Authors: Chorowski Maciej
Published: March 2022

Polski system elektroenergetyczny jest obecnie w okresie transformacji wynikającej zarówno ze stanu technicznego jednostek wytwórczych energii elektrycznej, jak i z założeń polityki klimatycznej wyrażonych w Zielonym Ładzie. Proces transformacji jest odzwierciedlony w Polityce Energetycznej Polski do 2040 r. (PEP 2040) i zakłada duży wzrost niestabilnych źródeł OZE w miksie energetycznym. Stabilizacja tych źródeł będzie możliwa poprzez modernizację ciepłownictwa polegającą na zamianie źródeł ciepła na systemy kogeneracyjne. Kogeneracja stanie się technologią regulacyjną w systemie elektroenergetycznym i zacznie wykorzystywać na dużą skalę magazyny ciepła i chłodu również w okresie letnim. W pracy omówiono procesy transformacji polskiej energetyki oraz uwypuklono rolę ciepłownictwa w tym procesie, w szczególności kogeneracji i trigeneracji.
Rewolucja energetyczna z perspektywy samorządu. Jak to zrobić skutecznie?
Authors: Popkiewicz Marcin
Published: March 2022

Spalanie paliw kopalnych przenika całą naszą gospodarkę: elektrownie węglowe i gazowe, pojazdy na ropę, ogrzewanie gazem ziemnym i węglem. Żyjemy w takim świecie od zawsze, przyzwyczailiśmy się do tego, jak on działa. A teraz nagle okazuje się, że musimy od nich prawie całkowicie odejść, na dodatek nadzwyczaj szybko, w 30 lat redukując ich spalanie prawie do zera. Trzymanie się utrwalonych wzorców myślenia i działania nie doprowadzi nas do tego celu. Potrzebujemy zmiany mentalności i innowacji pozwalających na szybką, głęboką i powszechną przebudowę infrastruktury. W artykule przyjrzymy się bliżej megatrendom energetyczno-klimatycznym oraz celowi, do którego dążymy, zgodnie z Porozumieniem Paryskim i politykami Europejskiego Zielonego Ładu. Przyjrzymy się też, jak będzie wyglądał kształtujący się nowy system energetyczny bez paliw kopalnych i jakie to będzie miało implikacje dla budynków czy transportu. Zastanowimy się też, jak to zrobić, od czego.
Elastyczność w sieci OSD jako kluczowy komponent transformacji energetycznej
Authors: Wawrzyniak Karol , Walkowiak Sławomir , Cetnarski Ryszard
Published: March 2022

Zmiany w polityce klimatycznej, zarówno na szczeblu krajowym, jaki i europejskim, w tym wymaganie neutralności klimatycznej do roku 2050, przekładają się na intensyfikację procesów transformacji miksu elektorenergetycznego. W pracy przeprowadzono analizy ilościowe i jakościowe wybranych scenariuszy transformacji sektora mieszkaniowego w Polsce (łącznie około 50% zapotrzebowania na ciepło i energię elektryczną względem roku 2018). Do 2030 r. spodziewany jest istotny wzrost zapotrzebowania na energię elektryczną, co związane jest z znaczącymi nakładami na modernizację KSE. Niniejsza praca pokazuje strategię obniżenia kosztów modernizacji KSE poprzez przedstawienie różnych podejść do zwiększenia zasobów elastyczności w KSE. Wśród nich przedstawiona jest koncepcja lokalnego bilansowania, na które składa się: autokonsumpcja chwilowa oraz bilansowanie techniczne. Zaproponowane zostały niezbędne mechanizmy regulacyjne.
Obowiązki regulacyjne spoczywające na przedsiębiorstwach energetycznych i pozostałych użytkownikach systemu energetycznego
Authors: Będkowski-Kozioł Michał , Wrochna Wojciech
Published: March 2022

Liberalizacja funkcjonowania sektora energetycznego, która została zapoczątkowana w latach 90. ubiegłego wieku, a której głównym celem było wprowadzenie mechanizmów konkurencji w opartym dotychczas na paradygmacie monopolu sektorze energetycznym, powiązana jest ze swoistym „paradoksem regulacyjnym”. Polega on na nałożeniu na przedsiębiorstwa energetyczne oraz pozostałych użytkowników systemu energetycznego szeregu obowiązków regulacyjnych, które mają na celu promowanie konkurencji w energetyce przy jednoczesnym zagwarantowaniu świadczenia tzw. usług powszechnych na rzecz odbiorców paliw i energii. Celem artykułu jest przedstawienie najistotniejszych spośród tych obowiązków wraz ze wskazaniem przewidzianych prawem wyłączeń w zakresie ich stosowania.
Inhibiting USP16 rescues stem cell aging and memory in an Alzheimer’s model
Authors: Reinitz Felicia , Chen Elizabeth Y , Nicolis di Robilant Benedetta , Chuluun Bayarsaikhan , Antony Jane , Jones Robert C , Gubbi Neha , Lee Karen , Ho William Hai Dang , Kolluru Sai Saroja , Qian Dalong , Adorno Maddalena , Piltti Katja , Anderson Aileen , Monje Michelle , Heller H Craig , Quake Stephen R , Clarke Michael F
Published: March 2022

Alzheimer’s disease (AD) is a progressive neurodegenerative disease observed with aging that represents the most common form of dementia. To date, therapies targeting end-stage disease plaques, tangles, or inflammation have limited efficacy. Therefore, we set out to identify a potential earlier targetable phenotype. Utilizing a mouse model of AD and human fetal cells harboring mutant amyloid precursor protein, we show cell intrinsic neural precursor cell (NPC) dysfunction precedes widespread inflammation and amyloid plaque pathology, making it the earliest defect in the evolution of the disease. We demonstrate that reversing impaired NPC self-renewal via genetic reduction of USP16, a histone modifier and critical physiological antagonist of the Polycomb Repressor Complex 1, can prevent downstream cognitive defects and decrease astrogliosis in vivo. Reduction of USP16 led to decreased expression of senescence gene Cdkn2a and mitigated aberrant regulation of the Bone Morphogenetic Signaling (BMP) pathway, a previously unknown function of USP16. Thus, we reveal USP16 as a novel target in an AD model that can both ameliorate the NPC defect and rescue memory and learning through its regulation of both Cdkn2a and BMP signaling.
How to assemble a scale-invariant gradient
Authors: Datta Arnab , Ghosh Sagnik , Kondev Jane
Published: March 2022

Intracellular protein gradients serve a variety of functions, such as the establishment of cell polarity or to provide positional information for gene expression in developing embryos. Given that cell size in a population can vary considerably, for the protein gradients to work properly they often have to be scaled to the size of the cell. Here, we examine a model of protein gradient formation within a cell that relies on cytoplasmic diffusion and cortical transport of proteins toward a cell pole. We show that the shape of the protein gradient is determined solely by the cell geometry. Furthermore, we show that the length scale over which the protein concentration in the gradient varies is determined by the linear dimensions of the cell, independent of the diffusion constant or the transport speed. This gradient provides scale-invariant positional information within a cell, which can be used for assembly of intracellular structures whose size is scaled to the linear dimensions of the cell, such as the cytokinetic ring and actin cables in budding yeast cells.
Perceptual coupling and decoupling of the default mode network during mind-wandering and reading
Authors: Zhang Meichao , Bernhardt Boris C , Wang Xiuyi , Varga Dominika , Krieger-Redwood Katya , Royer Jessica , Rodríguez-Cruces Raúl , Vos de Wael Reinder , Margulies Daniel S , Smallwood Jonathan , Jefferies Elizabeth
Published: March 2022

While reading, our mind can wander to unrelated autobiographical information, creating a perceptually decoupled state detrimental to narrative comprehension. To understand how this mind-wandering state emerges, we asked whether retrieving autobiographical content necessitates functional disengagement from visual input. In Experiment 1, brain activity was recorded using functional magnetic resonance imaging (fMRI) in an experimental situation mimicking naturally occurring mind-wandering, allowing us to precisely delineate neural regions involved in memory and reading. Individuals read expository texts and ignored personally relevant autobiographical memories, as well as the opposite situation. Medial regions of the default mode network (DMN) were recruited during memory retrieval. In contrast, left temporal and lateral prefrontal regions of the DMN, as well as ventral visual cortex, were recruited when reading for comprehension. Experiment two used functional connectivity both at rest and during tasks to establish that (i) DMN regions linked to memory are more functionally decoupled from regions of ventral visual cortex than regions in the same network engaged when reading; and (ii) individuals with more self-generated mental contents and poorer comprehension, while reading in the lab, showed more decoupling between visually connected DMN sites important for reading and primary visual cortex. A similar pattern of connectivity was found in Experiment 1, with greater coupling between this DMN site and visual cortex when participants reported greater focus on reading in the face of conflict from autobiographical memory cues; moreover, the retrieval of personally relevant memories increased the decoupling of these sites. These converging data suggest we lose track of the narrative when our minds wander because generating autobiographical mental content relies on cortical regions within the DMN which are functionally decoupled from ventral visual regions engaged during reading.
The biology of C. richardii as a tool to understand plant evolution
Authors: Kinosian Sylvia P , Wolf Paul G
Published: March 2022

The fern Ceratopteris richardii has been studied as a model organism for over 50 years because it is easy to grow and has a short life cycle. In particular, as the first homosporous vascular plant for which genomic resources were developed, C. richardii has been an important system for studying plant evolution. However, we know relatively little about the natural history of C. richardii. In this article, we summarize what is known about this aspect of C. richardii, and discuss how learning more about its natural history could greatly increase our understanding of the evolution of land plants.
N-mixture models provide informative crocodile (Crocodylus moreletii) abundance estimates in dynamic environments
Authors: Lemos Barão-Nóbrega José António , González-Jaurégui Mauricio , Jehle Robert
Published: March 2022

Estimates of animal abundance provide essential information for population ecological studies. However, the recording of individuals in the field can be challenging, and accurate estimates require analytical techniques which account for imperfect detection. Here, we quantify local abundances and overall population size of Morelet’s crocodiles (Crocodylus moreletii) in the region of Calakmul (Campeche, Mexico), comparing traditional approaches for crocodylians (Minimum Population Size—MPS; King’s Visible Fraction Method—VFM) with binomial N-mixture models based on Poisson, zero-inflated Poisson (ZIP) and negative binomial (NB) distributions. A total of 191 nocturnal spotlight surveys were conducted across 40 representative locations (hydrologically highly dynamic aquatic sites locally known as aguadas) over a period of 3 years (2017–2019). Local abundance estimates revealed a median of 1 both through MPS (min–max: 0–89; first and third quartiles, Q1–Q3: 0–7) and VFM (0–112; Q1–Q3: 0–9) non-hatchling C. moreletii for each aguada, respectively. The ZIP based N-mixture approach shown overall superior confidence over Poisson and NB, and revealed a median of 6 ± 3 individuals (min = 0; max = 120 ± 18; Q1 = 0; Q3 = 18 ± 4) jointly with higher detectabilities in drying aguadas with low and intermediate vegetation cover. Extrapolating these inferences across all waterbodies in the study area yielded an estimated ~10,000 (7,000–11,000) C. moreletii present, highlighting Calakmul as an important region for this species. Because covariates enable insights into population responses to local environmental conditions, N-mixture models applied to spotlight count data result in particularly insightful estimates of crocodylian detection and abundance.
Focus on Polish nurses’ health condition: a cross-sectional study
Authors: Bartosiewicz Anna , Łuszczki Edyta , Jagielski Pawel , Oleksy Lukasz , Stolarczyk Artur , Dereń Katarzyna
Published: March 2022

Background

The nursing profession carries with it many negative factors and a high risk of developing chronic diseases, including overweight and obesity. According to statistics, the health condition of this professional group is much worse than that of the average population of the same age. As the largest and most trusted professional group in the world, nurses are critical to the health of any nation. The aim of the study was to assess the Polish nurse’s health condition based on real measurements of parameters important for the occurrence of metabolic diseases.

Methods

This is the cross-sectional, conducted among two age groups of Polish nurses (<50 years and ≥50 years). Study included the measurements with DXA, the assessment of glucose concentration and lipid profile, the measurement of blood pressure and socio-demographic data of the surveyed nurses.

Results

The majority of respondents above 50 years old were nurses with elevated total cholesterol (79.3%), elevated LDL cholesterol (72.8%), 42.4% of studied nurses had hypertension.

Conclusion

Individual, local and national measures to prevent and support the health of this professional group are needed.
Chikungunya virus time course infection of human macrophages reveals intracellular signaling pathways relevant to repurposed therapeutics
Authors: Gray Madison , Guerrero-Arguero Israel , Solis-Leal Antonio , Robison Richard A. , Berges Bradford K. , Pickett Brett E.
Published: March 2022

Background

Chikungunya virus (CHIKV) is a mosquito-borne pathogen, within the Alphavirus genus of the Togaviridae family, that causes ~1.1 million human infections annually. CHIKV uses Aedes albopictus and Aedes aegypti mosquitoes as insect vectors. Human infections can develop arthralgia and myalgia, which results in debilitating pain for weeks, months, and even years after acute infection. No therapeutic treatments or vaccines currently exist for many alphaviruses, including CHIKV. Targeting the phagocytosis of CHIKV by macrophages after mosquito transmission plays an important role in early productive viral infection in humans, and could reduce viral replication and/or symptoms.

Methods

To better characterize the transcriptional response of macrophages during early infection, we generated RNA-sequencing data from a CHIKV-infected human macrophage cell line at eight or 24 hours post-infection (hpi), together with mock-infected controls. We then calculated differential gene expression, enriched functional annotations, modulated intracellular signaling pathways, and predicted therapeutic drugs from these sequencing data.

Results

We observed 234 pathways were significantly affected 24 hpi, resulting in six potential pharmaceutical treatments to modulate the affected pathways. A subset of significant pathways at 24 hpi includes AGE-RAGE, Fc epsilon RI, Chronic myeloid leukemia, Fc gamma R-mediated phagocytosis, and Ras signaling. We found that the MAPK1 and MAPK3 proteins are shared among this subset of pathways and that Telmisartan and Dasatinib are strong candidates for repurposed small molecule therapeutics that target human processes. The results of our analysis can be further characterized in the wet lab to contribute to the development of host-based prophylactics and therapeutics.