bluuebunny/crossref_metadata_2025 huggingface dataset:
Stereoselective Alkane Oxidation with meta-Chloroperoxybenzoic Acid (MCPBA) Catalyzed by Organometallic Cobalt Complexes
Authors: Shul’pin Georgiy , Loginov Dmitriy , Shul’pina Lidia , Ikonnikov Nikolay , Idrisov Vladislav , Vinogradov Mikhail , Osipov Sergey , Nelyubina Yulia , Tyubaeva Polina
Published: November 2016

Cobalt pi-complexes, previously described in the literature and specially synthesized and characterized in this work, were used as catalysts in homogeneous oxidation of organic compounds with peroxides. These complexes contain pi-butadienyl and pi-cyclopentadienyl ligands: [(tetramethylcyclobutadiene)(benzene)cobalt] hexafluorophosphate, [(C4Me4)Co(C6H6)]PF6 (1); diiodo(carbonyl)(pentamethylcyclopentadienyl)cobalt, Cp*Co(CO)I2 (2); diiodo(carbonyl)(cyclopentadienyl)cobalt, CpCo(CO)I2 (3); (tetramethylcyclobutadiene)(dicarbonyl)(iodo)cobalt, (C4Me4)Co(CO)2I (4); [(tetramethylcyclobutadiene)(acetonitrile)(2,2′-bipyridyl)cobalt] hexafluorophosphate, [(C4Me4)Co(bipy)(MeCN)]PF6 (5); bis[dicarbonyl(B-cyclohexylborole)]cobalt, [(C4H4BCy)Co(CO)2]2 (6); [(pentamethylcyclopentadienyl)(iodo)(1,10-phenanthroline)cobalt] hexafluorophosphate, [Cp*Co(phen)I]PF6 (7); diiodo(cyclopentadienyl)cobalt, [CpCoI2]2 (8); [(cyclopentadienyl)(iodo)(2,2′-bipyridyl)cobalt] hexafluorophosphate, [CpCo(bipy)I]PF6 (9); and [(pentamethylcyclopentadienyl)(iodo)(2,2′-bipyridyl)cobalt] hexafluorophosphate, [Cp*Co(bipy)I]PF6 (10). Complexes 1 and 2 catalyze very efficient and stereoselective oxygenation of tertiary C–H bonds in isomeric dimethylcyclohexanes with MCBA: cyclohexanols are produced in 39 and 53% yields and with the trans/cis ratio (of isomers with mutual trans- or cis-configuration of two methyl groups) 0.05 and 0.06, respectively. Addition of nitric acid as co-catalyst dramatically enhances both the yield of oxygenates and stereoselectivity parameter. In contrast to compounds 1 and 2, complexes 9 and 10 turned out to be very poor catalysts (the yields of oxygenates in the reaction with cis-1,2-dimethylcyclohexane were only 5%–7% and trans/cis ratio 0.8 indicated that the oxidation is not stereoselective). The chromatograms of the reaction mixture obtained before and after reduction with PPh3 are very similar, which testifies that alkyl hydroperoxides are not formed in this oxidation. It can be thus concluded that the interaction of the alkanes with MCPBA occurs without the formation of free radicals. The complexes catalyze oxidation of alcohols with tert-butylhydroperoxide (TBHP). For example, tert-BuOOH efficiently oxidizes 1-phenylethanol to acetophenone in 98% yield if compound 1 is used as a catalyst.
Multi-Functional Nanogels for Tumor Targeting and Redox-Sensitive Drug and siRNA Delivery
Authors: Adamo Giorgia , Grimaldi Natascia , Campora Simona , Bulone Donatella , Bondì Maria , Al-Sheikhly Mohamad , Sabatino Maria , Dispenza Clelia , Ghersi Giulio
Published: November 2016

(1) Background: A new family of nanosystems able to discern between normal and tumor cells and to release a therapeutic agent in controlled way were synthetized by e-beam irradiation. This technique permits to obtain biocompatible, sterile, carboxyl-functionalized polyvinylpyrrolidone (PVP-co-acrylic acid) nanogels (NGs); (2) Methods: Here, we performed a targeting strategy based on the recognition of over-expressed proteins on tumor cells, like the folate receptor. The selective targeting was demonstrated by co-culture studies and flow cytometry analysis, using folate conjugated NGs. Moreover, nanoparticles were conjugated to a chemotherapeutic drug or to a pro-apoptotic siRNA through a glutathione sensitive spacer, in order to obtain a controlled release mechanism, specific for cancer cells. The drug efficiency was tested on tumor and healthy cells by flow cytometric analysis, confocal and epifluorescence microscopy and cytotoxicity assay; the siRNA effect was investigated by RNAi experiment; (3) Results: The data obtained showed that the use of NGs permits a faster cargo release in cancer cells, in response to high cytosolic glutathione level, also improving their efficacy; (4) Conclusion: The possibility of releasing biological molecules in a controlled way and to recognize a specific tumor target allows overcoming the typical limits of the classic cancer therapy.
Kuwanon G Preserves LPS-Induced Disruption of Gut Epithelial Barrier In Vitro
Authors: Guo Hengli , Xu Youhua , Huang Wei , Zhou Hua , Zheng Zhaoguang , Zhao Yonghua , He Bao , Zhu Tingting , Tang Shanshan , Zhu Quan
Published: November 2016

Defects in the gut epithelial barrier have now been recognized to be responsible for diabetic endotoxemia. In everyday life, Mulberry leaf tea is widely used in Asian nations due to its proposed benefits to health and control of diabetes. Evidence indicates the potential role of Kuwanon G (KWG), a component from Morus alba L., on blocking the gut epithelial barrier. In lipopolysaccharides (LPS)-damaged Caco-2 cells, it was found that KWG increased the viability of cells in a concentration-dependent manner. KWG administration significantly elevated the anti-oxidant abilities via increasing ratio of superoxidase dismutase (SOD)/malondialdehyde (MDA) and decreasing reactive oxygen species (ROS) within the cells. During KWG incubation, pro-inflammatory cytokines including interleukin (IL)-1β and tumor necrosis factor (TNF)-α were significantly reduced, tight junction proteins including zonula occludens (ZO)-1, intercellular adhesion molecule (ICAM)-1 and Occludin were dramatically increased as detected by immunofluorescence assay, trans-epithelial electrical resistance was significantly increased and the transmission of albumin-fluorescein isothiocyanate (FITC) across the barrier was decreased. In conclusion, the present study demonstrated that KWG could ameliorate LPS-induced disruption of the gut epithelial barrier by increasing cell viability and tight junction between cells, and decreasing pro-inflammatory cytokines and oxidative damage.
Synthesis and Evaluation of New Benzodioxole- Based Thiosemicarbazone Derivatives as Potential Antitumor Agents
Authors: Altıntop Mehlika , Temel Halide , Sever Belgin , Akalın Çiftçi Gülşen , Kaplancıklı Zafer
Published: November 2016

New benzodioxole-based thiosemicarbazone derivatives were synthesized and evaluated for their cytotoxic effects on A549 human lung adenocarcinoma, C6 rat glioma and NIH/3T3 mouse embryonic fibroblast cells. In order to examine the correlation between anticancer activity and cholinesterases, the compounds were evaluated for their inhibitory effects on AChE and BuChE. The most effective anticancer agents were investigated for their effects on DNA synthesis, apoptosis and mitochondrial membrane potential. 4-(1,3-Benzodioxol-5-yl)-1-([1,1′-biphenyl]-4-ylmethylene)thiosemicarbazide (5) was identified as the most promising anticancer agent against C6 and A549 cell lines due to its inhibitory effects on C6 and A549 cells and low toxicity to NIH/3T3 cells. Compound 5 increased early and late apoptosis in A549 and C6 cells. Compound 5 also caused disturbance on mitochondrial membrane potential and showed DNA synthesis inhibitory activity in A549 and C6 cells. Compound 5 was investigated for SIRT1 inhibitory activity to provide mechanistic insight and for that purpose docking studies were also performed for this compound on SIRT1. On the other hand, compound 5 did not show any inhibitory activity against AChE and BuChE. This outcome pointed out that there is no relationship between anticancer activity of compound 5 and cholinesterases.
1-Deoxynojirimycin: Occurrence, Extraction, Chemistry, Oral Pharmacokinetics, Biological Activities and In Silico Target Fishing
Authors: Gao Kuo , Zheng Chenglong , Wang Tong , Zhao Huihui , Wang Juan , Wang Zhiyong , Zhai Xing , Jia Zijun , Chen Jianxin , Zhou Yingwu , Wang Wei
Published: November 2016

1-Deoxynojirimycin (DNJ, C6H13NO4, 163.17 g/mol), an alkaloid azasugar or iminosugar, is a biologically active natural compound that exists in mulberry leaves and Commelina communis (dayflower) as well as from several bacterial strains such as Bacillus and Streptomyces species. Deoxynojirimycin possesses antihyperglycemic, anti-obesity, and antiviral features. Therefore, the aim of this detailed review article is to summarize the existing knowledge on occurrence, extraction, purification, determination, chemistry, and bioactivities of DNJ, so that researchers may use it to explore future perspectives of research on DNJ. Moreover, possible molecular targets of DNJ will also be investigated using suitable in silico approach.
Damxungmacin A and B, Two New Amicoumacins with Rare Heterocyclic Cores Isolated from Bacillus subtilis XZ-7
Authors: Tang Hui-Ling , Sun Cheng-Hang , Hu Xin-Xin , You Xue-Fu , Wang Min , Liu Shao-Wei
Published: November 2016

Two new amicoumacins, named Damxungmacin A (1) and B (2), were isolated from the culture broth of a soil-derived bacterium Bacillus subtilis XZ-7. Their chemical structures were elucidated by spectroscopic studies (UV, IR, NMR and HR-ESI-MS). Compound 1 possessed a 1,4-diazabicyclo[2.2.1]heptane-2-one ring system in its structure, which was reported for the first time, while 2 had a 1-acetylmorpholine-3-one moiety, which was naturally rare. Compound 1 exhibited moderate to weak cytotoxic activities against three human tumor cell lines (A549, HCT116 and HepG2) with IC50 values of 13.33, 14.34 and 13.64 μM, respectively. Meanwhile, compound 1 showed weak antibacterial activities against some strains of Staphylococcus epidermidis, while compound 2 at 16 μg/mL did not show antibacterial activity.
Ellagic Acid Inhibits Bladder Cancer Invasiveness and In Vivo Tumor Growth
Authors: Ceci Claudia , Tentori Lucio , Atzori Maria , Lacal Pedro , Bonanno Elena , Scimeca Manuel , Cicconi Rosella , Mattei Maurizio , De Martino Maria , Vespasiani Giuseppe , Miano Roberto , Graziani Grazia
Published: November 2016

Ellagic acid (EA) is a polyphenolic compound that can be found as a naturally occurring hydrolysis product of ellagitannins in pomegranates, berries, grapes, green tea and nuts. Previous studies have reported the antitumor properties of EA mainly using in vitro models. No data are available about EA influence on bladder cancer cell invasion of the extracellular matrix triggered by vascular endothelial growth factor-A (VEGF-A), an angiogenic factor associated with disease progression and recurrence, and tumor growth in vivo. In this study, we have investigated EA activity against four different human bladder cancer cell lines (i.e., T24, UM-UC-3, 5637 and HT-1376) by in vitro proliferation tests (measuring metabolic and foci forming activity), invasion and chemotactic assays in response to VEGF-A and in vivo preclinical models in nude mice. Results indicate that EA exerts anti-proliferative effects as a single agent and enhances the antitumor activity of mitomycin C, which is commonly used for the treatment of bladder cancer. EA also inhibits tumor invasion and chemotaxis, specifically induced by VEGF-A, and reduces VEGFR-2 expression. Moreover, EA down-regulates the expression of programmed cell death ligand 1 (PD-L1), an immune checkpoint involved in immune escape. EA in vitro activity was confirmed by the results of in vivo studies showing a significant reduction of the growth rate, infiltrative behavior and tumor-associated angiogenesis of human bladder cancer xenografts. In conclusion, these results suggest that EA may have a potential role as an adjunct therapy for bladder cancer.
Effects of Two-Year Vitamin B12 and Folic Acid Supplementation on Depressive Symptoms and Quality of Life in Older Adults with Elevated Homocysteine Concentrations: Additional Results from the B-PROOF Study, an RCT
Authors: De Koning Elisa , Van der Zwaluw Nikita , Van Wijngaarden Janneke , Sohl Evelien , Brouwer-Brolsma Elske , Van Marwijk Harm , Enneman Anke , Swart Karin , Van Dijk Suzanne , Ham Annelies , Van der Velde Nathalie , Uitterlinden André , Penninx Brenda , Elders Petra , Lips Paul , Dhonukshe-Rutten Rosalie , Van Schoor Natasja , De Groot Lisette
Published: November 2016

Lowering elevated plasma homocysteine (Hcy) concentrations by supplementing vitamin B12 and folic acid may reduce depressive symptoms and improve health-related quality of life (HR-QoL) in older adults. This study aimed to test this hypothesis in a randomized controlled trial. Participants (N = 2919, ≥65 years, Hcy concentrations ≥12 µmol/L) received either 500 µg vitamin B12 and 400 µg folic acid daily or placebo for two years. Both tablets contained 15 µg vitamin D3. Depressive symptoms were measured with the Geriatric Depression Scale-15 (GDS-15). HR-QoL was assessed with the SF-12 Mental and Physical component summary scores and the EQ-5D Index score and Visual Analogue Scale. Differences in two-year change scores were analyzed with Analysis of Covariance (ANCOVA). Hcy concentrations decreased more in the intervention group, but two-year change scores of the GDS-15 and three of four HR-QoL measures did not differ between groups. The EQ-5D Index score declined less in the intervention group than in the placebo group (mean change 0.00 vs. −0.02, p = 0.004). In conclusion, two-year supplementation with vitamin B12 and folic acid in older adults with hyperhomocysteinemia showed that lowering Hcy concentrations does not reduce depressive symptoms, but it may have a small positive effect on HR-QoL.
Locally Enhanced and Tunable Optical Chirality in Helical Metamaterials
Authors: Gutsche Philipp , Mäusle Raquel , Burger Sven
Published: November 2016

We report on a numerical study of optical chirality. Intertwined gold helices illuminated with plane waves concentrate right and left circularly polarized electromagnetic field energy to sub-wavelength regions. These spots of enhanced chirality can be smoothly shifted in position and magnitude by varying illumination parameters, allowing for the control of light-matter interactions on a nanometer scale.
Evaluation of Hyaluronic Acid Dilutions at Different Concentrations Using a Quartz Crystal Resonator (QCR) for the Potential Diagnosis of Arthritic Diseases
Authors: Ahumada Luis , González Marco , Sandoval Oscar , Olmedo José
Published: November 2016

The main objective of this article is to demonstrate through experimental means the capacity of the quartz crystal resonator (QCR) to characterize biological samples of aqueous dilutions of hyaluronic acid according to their viscosity and how this capacity may be useful in the potential diagnosis of arthritic diseases. The synovial fluid is viscous due to the presence of hyaluronic acid, synthesized by synovial lining cells (type B), and secreted into the synovial fluid thus making the fluid viscous. In consequence, aqueous dilutions of hyaluronic acid may be used as samples to emulate the synovial fluid. Due to the viscoelastic and pseudo-plastic behavior of hyaluronic acid, it is necessary to use the Rouse model in order to obtain viscosity values comparable with viscometer measures. A Fungilab viscometer (rheometer) was used to obtain reference measures of the viscosity in each sample in order to compare them with the QCR prototype measures.
Introduction of Behavioral Parameterization in the EPC Calculation Method and Assessment of Five Typical Urban Houses in Wallonia, Belgium
Authors: Monfils Stéphane , Hauglustaine Jean-Marie
Published: November 2016

The Energy Performance Certification (EPC) of existing residential buildings has been designed to introduce energy efficiency as a comparative criterion for real-estate purchase choices, which should influence real-estate market value and stimulate energy saving investments. EPCs in Belgium are asset ratings, calculated with a standardized approach, which purposefully (and understandably) takes the human factor out of the equations in order to allow the comparison of buildings. As a result, they often overestimate energy consumption and present discrepancies that do not allow appropriation of the results by potential buyers. This study proposes complementary EPC results, obtained by integrating the behavior of occupants in the calculation method. This paper first analyses the pool of behavioral uncertainties that influence the results of EPCs, describes a questionnaire built to gather additional data on households’ characteristics and energy consumption habits and proposes modifications to the calculation method. The complementary results are then compared to regulatory EPC results and real consumption data. Though acknowledging the necessity of a standardized EPC for dwellings’ comparison, this study completes it with data on the energy consumption-related behaviors to (partially) close the gap between real and theoretical consumptions.
Implementation of Circular Economy Business Models by Small and Medium-Sized Enterprises (SMEs): Barriers and Enablers
Authors: Rizos Vasileios , Behrens Arno , Van der Gaast Wytze , Hofman Erwin , Ioannou Anastasia , Kafyeke Terri , Flamos Alexandros , Rinaldi Roberto , Papadelis Sotiris , Hirschnitz-Garbers Martin , Topi Corrado
Published: November 2016

Small and medium-sized enterprises (SMEs) are increasingly aware of the benefits of closing loops and improving resource efficiency, such as saving material costs, creating competitive advantages, and accessing new markets. At the same time, however, various barriers pose challenges to small businesses in their transition to a circular economy, namely a lack of financial resources and lack of technical skills. The aim of this paper is to increase knowledge and understanding about the barriers and enablers experienced by SMEs when implementing circular economy business models. Looking first at the barriers that prevent SMEs from realising the benefits of the circular economy, an investigation is carried out in the form of a literature review and an analysis of a sample of SME case studies that are featured on the GreenEcoNet EU-funded web platform. Several enabling factors that help SMEs adopt circular economy practices are then identified. The paper concludes that although various policy instruments are available to help SMEs incorporate circular economy principles into their business models, several barriers remain. The authors recommend that European and national policies strengthen their focus on greening consumer preferences, market value chains and company cultures, and support the recognition of SMEs’ green business models. This can be achieved through the creation of dedicated marketplaces and communities of practice, for example.
Du bitume à la résine : à propos du remplissage d'une oreille de griffon de Delphes
Authors: Rolley Claude , Langlois Juliette , Balcar Nathalie , Regert Martine
Published: November 2016

Claude ROLLEY, Juliette LANGLOIS, Nathalie BALCAR and Martine REGERT

From Bitumen to Resin : On the Filling Inside the Ear of a Griffin from Delphi

p. 55-65

The filling inside the ear of the protome of a hammered bronze griffin from Delphi is bitumen. This is one more argument for a Near Eastern origin for the manufacture of hammered cauldron protomes discovered in Greece and Etruria.
Exploration of the Archaic Sanctuary at Mandra on Despotiko
Authors: Kourayos Yannos , Burns Bryan
Published: November 2016

Yannos Kourayos and Bryan Burns

Exploration of the archaic sanctuary at Mandra on the island of Despotiko

p. 133-174

The results are presented of the archaeological excavation at the site of Mandra on Despotiko, an uninhabited island west of Paros and Antiparos. Initial investigations of surface material led to a full scale excavation centring on Building A, a large structure consisting of five parallel rooms, which may have been a hestiatorion. The general status of the site as a sanctuary is confirmed by numerous votive finds. The majority of artefacts recovered thus far date to the Archaic period, including sculptural fragments, imported ceramics, and a wide range of metal objects and small finds. Architectural members, most of which were rebuilt into later structures, indicate the presence of several other Doric buildings on the site, and a long stone wall encloses a large area east of Building A. The name Apollo inscribed on sherds suggests that this sanctuary was dedicated to the god. The feminine nature of many ex-votos and the presence of several Delian sanctuaries throughout the Cyclades, however, may indicate that Artemis was also worshipped there.
La porte de Zeus à Thasos
Authors: Grandjean Yves , Kozelj Tony , Salviat François
Published: November 2016

Yves Grandjean, Tony Kozelj και François Salviat

H πύλη του Δία στη Θάσο

σ. 175-268

Η πύλη του Δία και της Ήρας στη Θάσο, προσφορά του Πύθιππου, γιου του Παιεστράτου, αποτελεί ένα από τα πιο αξιοσημείωτα στοιχεία του τείχους της Θάσου: εκτός από τα ανάγλυφα που τη διακοσμούσαν, έφερε και συγκεκριμένο, πρωτότυπο αρχιτεκτονικό διάκοσμο, ο οποίος δεν έχει ποτέ αναλυθεί στο σύνολο του. Η ύπαρξη κατά χώραν πολλών τμημάτων επιτρέπει την σχεδιαστική αναπαράσταση της πύλης

— στην πραγματικότητα μια πύργος-πύλη — , με επάλληλους αρχιτεκτονικούς ρυθμούς

— δωρικό και ιωνικό — στην όψη της προς την πόλη και δωρική ζωφόρο ενσωματωμένη στους τοίχους του πύργου στην όψη της προς την ύπαιθρο. Οι επιρροές της ταφικής και ανακτορικής μακεδονικής αρχιτεκτονικής είναι εμφανείς. Σύμφωνα με τους καταλόγους των θεωρών και τις σφραγίδες των αμφορέων που βρέθηκαν στα προγένεστερα στρώματα, η πύργος-πύλη αυτή κατασκευάστηκε γύρω στο 300 π. Χ. Διαδέχθηκε ένα αρχικό άνοιγμα, το οποίο χρονολογείται από την εποχή κατά την οποία χτίστηκε το σήμερα ορατό τείχος, δηλαδή ύστερα από την επιδρομή του Ιστιαίου της Μιλήτου εναντίον της Θάσου, το 494- Τόσο οι παλαιότερες ανασκαφές όσο και οι πρόσφατες έρευνες επιβεβαιώνουν τη μαρτυρία του Ηρόδοτου (VI 46), η οποία και δεν υπάρχει λόγος να αμφισβητηθεί.
En visitant et revisitant les ateliers amphoriques de Thasos
Authors: Garlan Yvon
Published: November 2016

Yvon Garlan

En visitant et revisitant les ateliers amphoriques de Thasos

p. 269-329

L'article fait le bilan des recherches sur les ateliers amphoriques de Thasos entreprises en 1977 et présente, sous forme de tableaux commentés et abondamment illustrés, les milliers de timbres qui en sont issus. Les dernières fouilles réalisées au Molos par le service archéologique ont fourni un matériel particulièrement abondant (plus de 3 000 exemplaires) et riche en indications sur les variantes de matrices et l'impression des cachets entre le dernier tiers du IVe siècle et le début de la seconde moitié du IIIe siècle. Le dépotoir de Chioni, fouillé en 1995 par l'École française d'Athènes, se scinde en deux ensembles : le premier contenant une cinquantaine de timbres «anciens » du milieu du IVe siècle et le second plus de 400 timbres «récents » qui mentionnent 85 éponymes postérieurs aux environs de 320. Chaque année, de 1978 à 2003, les sites connus ou présumés de production amphorique ont été l'objet de collectes de surface qui ont permis d'esquisser ou de compléter leur étude. La classification chronologique des magistrats amphoriques de Thasos a été revue en conséquence, sous forme d'un tableau argumenté, du début du timbrage «récent » (qui devrait se dater des environs de 333 av. J.-C.) jusque vers 210 (plusieurs décennies sans doute avant sa disparition).
D'or et de marbre : les sculptures hellénistiques dorées de Délos
Authors: Bourgeois Brigitte , Jockey Philippe
Published: November 2016

Brigitte Bourgeois και Philippe Jockey

Από χρυσό και μάρμαρο: τα επιχρυσωμένα ελληνιστικά γλυπτά της Δήλου

σ. 331-349

Οι έρευνες που διεξάγουμε ως προς την πολυχρωμία των ελληνιστικών γλυπτών της Δήλου μας επέτρεψαν να εμπλουτίσουμε το κύριο corpus των επιχρυσωμένων μαρμάρινων γλυπτών με νέα στοιχεία, αλλά και να τα προσδιορίσουμε τυπολογικά. Η οπτική εξέταση των γλυπτών στο βιντεομικροσκόπιο, σε συνδυασμό με την ανάλυση με φθοριούχος ακτινοβολία Χ των κατάλοιπων που απομονώσαμε με τον παραπάνω τρόπο, έφεραν στο φως τρεις βασικούς τύπους επιχρύσωσης με φύλλο χρυσού στη Δήλο, γύρω στο ιοο π. Χ.: τα επιχρυσωμένα αγάλματα, τα έργα στα οποία η επιχρύσωση δεν αποτελεί παρά έναν λαμπερό χρωματισμό στο πλαίσιο της γενικότερης πολυχρωμίας και τα έργα που προτείνουμε να ονομάσουμε « chrysochromes »· τα τελευταία παρουσιάζουν μια ιδιαιτερότητα που δεν είχε αναγνωριστεί έως τώρα, δηλ. συνδυάζουν την έντονη πολυχρωμία των ενδεδυμένων τμημάτων με το χρυσό χρώμα των γυμνών τμημάτων. Μεταξύ των σημαντικών αποτελεσμάτων μιας τέτοιας έρευνας συγκαταλέγεται και η ανακάλυψη ολικής επιχρύσωσης με φύλλο χρυσού στο δηλιακό αντίγραφο που φυλάσσεται στο Εθνικό Αρχαιολογικό Μουσείο στην Αθήνα του Διαδούμενου του Πολύκλειτου, επιχρυσωμένο με φύλλο χρυσού, κατά το πρότυπο επιχρυσωμένου χάλκινο αγάλματος, ή αγάλματος από χρυσό. Μια τέτοια χρήση της τεχνικής της επιχρύσωσης με φύλλο χρυσού στα δηλιακά αγάλματα απαίτει επανεξέταση του ζητήματος της αποδοχής αυτών των έργων στην αρχαιότητα και της επιτυχίας που είχε ο χρυσός στη Δήλο, όπως, αναμφισβήτητα, και σε άλλες περιοχές του ελληνικού κόσμου κατά την ίδια χρονική περίοδο.
In Search of a Roman Bathhouse in the Malia Area
Authors: Kelly Amanda
Published: November 2016

Amanda Kelly

À la recherche d'un bain romain dans la région de Malia

p. 607-627

On aborde ici l'importance de l'activité romaine dans la région de Malia et on examine l'éventualité de la présence d'un bain romain (public ou privé, mais plus vraisemblablement privé) dans la zone du marais. L'identification de trois clous d'espacement en terre cuite et de plusieurs fragments de pilae recueillis lors de la prospection de Malia, près de la basilique, suggère l'existence d'un bain romain dans les environs, quelque part dans le marais (probablement dans la région de la basilique). La présence de clous d'espacement en terre cuite dans l'arrière-pays maliote est révélatrice, puisque leur usage est presque exclusivement associé à des bains romains, ailleurs dans l'Orient romain (généralement datés des IIe et IIIe siècles apr. J.-C.).
Tucidide e l'anfizionia di Delfi
Authors: Mari Manuela
Published: November 2016

L'amphictionie delphique est absente des Histoires de Thucydide. On présente ici tous les événements qui s'inscrivent dans le champ historique de Thucydide, dans lesquels l'amphictionie a pu jouer un rôle ou dont le rôle est attesté par d'autres sources : dans quelques cas, le silence de Thucydide s'explique par les exigences et le rythme de la narration et par les critères adoptés pour la sélection des faits à raconter ; dans d'autres, il reflète l'absence effective de l'amphictionie dans la «grande histoire».

La non mention de l'amphictionie ne prouve pas le manque d'intérêt de Thucydide pour les facteurs religieux au cours de l'histoire. Il conserve en effet des informations importantes sur l'histoire de Delphes au Ve siècle, lorsqu'elles s'inscrivent dans la ligne, politico-militaire essentiellement, de son analyse historique. L'amphictionie ne fut jamais un instrument direct du pouvoir, même si elle réussit, dans certaines circonstances, à jouer un rôle politique indirect, le plus souvent sous la tutelle des puissants Etats pilotes. L'intérêt divers des historiens des Ve et IVe siècles pour l'amphictionie s'explique ainsi, à la lumière de cette discontinuité effective de son rôle «politique».
Un règlement trouvé dans le Réservoir de l'Inopos à Délos
Authors: Siard Hélène
Published: November 2016

La stèle publiée ici, découverte en 2003 remployée dans le Réservoir de l'Inopos à Délos, porte le règlement de l'Inopos. Il est possible de démontrer, en relisant les Comptes des Hiéropes, que ce nom désigne le Réservoir lui-même — typologiquement une kréné — et non le cours d'eau dans son ensemble. Le texte présente par ailleurs une difficulté : les indices de datation y apparaissent contradictoires. On peut, par hypothèse, supposer qu'il s'agit de la copie hellénistique d'un règlement plus ancien, remontant à l'époque classique ; il faut dans ce cas admettre que les premiers aménagements du Réservoir de l'Inopos sont d'une date antérieure à celle qu'on propose ordinairement.
Les inscriptions de Kallipolis d'Étolie
Authors: Rousset Denis , Laroche Didier
Published: November 2016

Δημοσίευση 25 νέων επιγραφών της Καλλίπολης της Αιτωλίας, οι οποίες προέρχονται σχεδόν όλες από τις ελληνογαλλικές ανασκαφές της περιόδου 1977-1979. Σε μια ημικυκλική εξέδρα, πάνω στην οποία στεκόταν πιθανότατα ένας έφιππος ανδριάντας, είχαν χαραχτεί 18 συντετμημένα τιμητικά ψηφίσματα, που χρονολογούνται στο 2ο αι. π.Χ. Αυτά είναι τα πρώτα ψηφίσματα που βρέθηκαν στην Αιτωλία και προέρχονται από μια αιτωλική πόλη. Η μελέτη των ψηφισμάτων οδηγεί στην εξέταση του τρόπου με τον οποίον καθοριζόταν η χρονολόγηση μέσω επωνύμων αρχόντων στην Καλλίπολη, δηλαδή άλλοτε από έναν άρχοντα, άλλοτε από περισσότερους άρχοντες και άλλοτε μόνο από το γραμματέα των αρχόντων. Τα κείμενα αυτά μας επιτρέπουν επίσης να σκιαγραφήσουμε το γεωγραφικό κύκλο των σχέσεων μιας μικρής πόλης της κεντρικής Ελλάδας. Μας οδηγούν τέλος στην εξέταση της σχέσης ανάμεσα στα ονόματα Καλλιπολίτας και Καλλιεύς, δύο εθνικά επίθετα που συνυπάρχουν για σχεδόν 80 χρόνια και δεν πρέπει να αντιπροσωπεύουν μια και μόνη πολιτική κοινότητα: το επίθετο Καλλιπολίτας χαρακτηρίζει τους πολίτες της πόλης, ενώ το επίθετο Καλλιεύς είναι ένα τοπικό εθνικό επίθετο, το οποίο χαρακτηρίζει το σύνολο ή κάποιο μέρος μόνο των κοινοτήτων της περιοχής, και το οποίο συνδέεται ίσως με μια από τις διοικητικές περιφέρειες της αιτωλικής συνομοσπονδίας. Ανάμεσα στα υπόλοιπα κείμενα που δημοσιεύονται εδώ, αξιοσημείωτο είναι ένα ανάθημα που αφιερώνεται στη θεοποιημένη Νύχτα και στην Αρτεμη. Η μελέτη ολοκληρώνεται με μια ανακεφαλαίωση των 18 ήδη γνωστών επιγραφών από το Κάλλιον-Καλλίπολη και από την προσωπογραφική μελέτη των Καλλιέων και των Καλλιπολιτών, η οποία αριθμεί 194 πρόσωπα.
Un mécène au service d'une déesse thasienne : décret pour Stilbôn (Thanar 1)
Authors: Fournier Julien , Prêtre Clarisse
Published: November 2016

Η ανασκαφή του 2004 στις βόρειες παρυφές του Αρτεμισίου της Θάσου οδήγησε στην ανακάλυψη ενός σπαράγματος ψηφίσματος προς τιμήν του Στίλβωνος από τη Θάσο, το οποίο χρονολογείται ανάμεσα στον 1ο αι. π.Χ. και στον 1ο αι. μ.Χ. Ο Στίλβων προσφέρθηκε να χρηματοδοτήσει τις οικοδομικές εργασίες και τις επισκευές στο ιερό μιας θεάς της πόλης. Το κείμενο, το οποίο έχει συνταχθεί σε ύφος ελάχιστα συμβατικό, δείχνει πώς εξελίχθηκε η συντήρηση των θρησκευτικών εγκαταστάσεων, η ευθύνη της οποίας πέρασε από την πολιτεία στους πλούσιους ιδιώτες.
Les poteries néolithiques à décor peint « noir sur rouge » en Grèce du Nord : matières premières et production
Authors: Malamidou Dimitra , Tsirtsoni Zoï , Yiouni Paraskevi , Lespez Laurent , Kilikoglou Vassilis , Τsolakidou Alexandra
Published: November 2016

This article presents the aims and main results of an interdisciplinary research programme devoted to the black-on-red painted pottery characteristic of the end of the Late Neolithic (4800/4700-3900/3800 BC) in north Greece. The macroscopic study makes it possible to distinguish four pottery groups covering east Macedonia and Thrace, the middle and upper valley of the Strymon, central Macedonia and west Macedonia. The more thoroughgoing study of the first group, the best documented of the four, involved a comparison of the chemical compositions of the pottery fabrics with those of the local deposits, and suggests the existence of at least four production sites in west Macedonia. In one case, it is virtually certain that one and the same source of clay was exploited, the precise location of which remains to be determined.
DEVELOPING A NEW APPROACH FOR EVALUATION OF BUSINESS PROCESSES IN A FUZZY ENVIRONMENT
Authors: BAGHERZADEH Ghasem , CYRUS Kaveh M. , YAZDANI-CHAMZINI Abdolreza , MIEČINSKIENĖ Algita
Published: November 2016

Evaluation of business processes plays a significant role in business development and improvement. Therefore, organizations need a systematic approach to evaluate all the changes through robust and powerful techniques that can formulate the relationship between the available information and the degree of the inherent uncertainty. In this paper, a set of operational variables are defined. Then, the SPSS software package is utilized to validate the gathered data. After that, the variables are categorized by the use of a clustering technique. Finally, five major factors are determined as the most effective components. According to the inherent uncertainty involved in the process of modelling, fuzzy set theory, a powerful mathematical tool is applied to handle the vagueness. In order to construct a knowledge base based on the fuzzy set theory, the linguistic concepts for each variable are defined. Lastly, membership functions are described and a set of fuzzy rules based on input-output parameters are written in MATLAB software environment. To demonstrate the potential application of the proposed approach, a real case study is illustrated. The results reflect the capability and effectiveness of the approach proposed in this paper.
LIGHT CURVE SOLUTIONS OF 12 ECCENTRIC KEPLER BINARIES AND ANALYSIS OF THEIR OUT-OF-ECLIPSE VARIABILITY
Authors: Kjurkchieva Diana , Vasileva Doroteya , Dimitrov Dinko
Published: November 2016

The eccentricity, periastron angle, orbital inclination, mass ratio, stellar temperatures, and relative stellar radii of 12 eclipsing eccentric binaries were determined on the basis of Kepler data. The analysis of their out-of-eclipse variability led to the following results: (i) KIC 10490980 exhibits rotational (spot-type) variability. (ii) Four new heartbeat stars were found: KIC 9344623 and KIC 10296163, which have wide tidally induced light humps, and KIC 9119405 and KIC 9673173, which have narrow “W-shape” features. (iii) KIC 4932691 shows oscillations with approximately the 18th harmonic of the orbital period. We established that the eccentric Kepler binaries fall below the envelope

days on the period–eccentricity diagram and that there is a surprising lack of eccentric binaries with periods of 25–35 days.
PROXIMA CENTAURI AS A BENCHMARK FOR STELLAR ACTIVITY INDICATORS IN THE NEAR-INFRARED
Authors: Robertson Paul , Bender Chad , Mahadevan Suvrath , Roy Arpita , Ramsey Lawrence W.
Published: November 2016

A new generation of dedicated Doppler spectrographs will attempt to detect low-mass exoplanets around mid- to late M stars at near-infrared (NIR) wavelengths, where those stars are brightest and have the most Doppler information content. A central requirement for the success of these instruments is to properly measure the component of radial velocity (RV) variability contributed by stellar magnetic activity and to account for it in exoplanet models of RV data. The wavelength coverage for many of these new instruments will not include the Ca ii H&K or Hα lines, the most frequently used absorption-line tracers of magnetic activity. Thus, it is necessary to define and characterize NIR activity indicators for mid- to late M stars in order to provide simultaneous activity metrics for NIR RV data. We have used the high-cadence UVES observations of the M5.5 dwarf Proxima Centauri from Fuhrmeister et al. to compare the activity sensitivity of eight NIR atomic lines to that of Hα. We find that equivalent-width-type measurements of the NIR K i doublet and the Ca ii NIR triplet are excellent proxies for the canonical optical tracers. The Ca ii triplet will be acquired by most of the new and upcoming NIR Doppler spectrographs, offering a common, reliable indicator of activity.
SPT0346-52: NEGLIGIBLE AGN ACTIVITY IN A COMPACT, HYPER-STARBURST GALAXY AT z = 5.7
Authors: Ma Jingzhe , Gonzalez Anthony. H. , Vieira J. D. , Aravena M. , Ashby M. L. N. , Béthermin M. , Bothwell M. S. , Brandt W. N. , Breuck C. de , Carlstrom J. E. , Chapman S. C. , Gullberg B. , Hezaveh Y. , Litke K. , Malkan M. , Marrone D. P. , McDonald M. , Murphy E. J. , Spilker J. S. , Sreevani J. , Stark A. A. , Strandet M. , Wang S. X.
Published: November 2016

We present Chandra ACIS-S and Australia Telescope Compact Array (ATCA) radio continuum observations of the strongly lensed dusty, star-forming galaxy SPT-S J034640-5204.9 (hereafter SPT0346-52) at z = 5.656. This galaxy has also been observed with ALMA, HST, Spitzer, Herschel, Atacama Pathfinder EXperiment, and the Very Large Telescope. Previous observations indicate that if the infrared (IR) emission is driven by star formation, then the inferred lensing-corrected star formation rate (SFR) (∼4500 M
☉ yr−1) and SFR surface density ΣSFR (∼2000 M
☉ yr−1 kpc−2) are both exceptionally high. It remained unclear from the previous data, however, whether a central active galactic nucleus (AGN) contributes appreciably to the IR luminosity. The Chandra upper limit shows that SPT0346-52 is consistent with being star formation dominated in the X-ray, and any AGN contribution to the IR emission is negligible. The ATCA radio continuum upper limits are also consistent with the FIR-to-radio correlation for star-forming galaxies with no indication of an additional AGN contribution. The observed prodigious intrinsic IR luminosity of (3.6 ± 0.3) × 1013
L
☉ originates almost solely from vigorous star formation activity. With an intrinsic source size of 0.61 ± 0.03 kpc, SPT0346-52 is confirmed to have one of the highest ΣSFR of any known galaxy. This high ΣSFR, which approaches the Eddington limit for a radiation pressure supported starburst, may be explained by a combination of very high star formation efficiency and gas fraction.
WHY ARE PULSAR PLANETS RARE?
Authors: Martin Rebecca G. , Livio Mario , Palaniswamy Divya
Published: November 2016

Pulsar timing observations have revealed planets around only a few pulsars. We suggest that the rarity of these planets is due mainly to two effects. First, we show that the most likely formation mechanism requires the destruction of a companion star. Only pulsars with a suitable companion (with an extreme mass ratio) are able to form planets. Second, while a dead zone (a region of low turbulence) in the disk is generally thought to be essential for planet formation, it is most probably rare in disks around pulsars, because of the irradiation from the pulsar. The irradiation strongly heats the inner parts of the disk, thus pushing the inner boundary of the dead zone out. We suggest that the rarity of pulsar planets can be explained by the low probability for these two requirements to be satisfied: a very low-mass companion and a dead zone.
THE RESOLVE SURVEY ATOMIC GAS CENSUS AND ENVIRONMENTAL INFLUENCES ON GALAXY GAS RESERVOIRS
Authors: Stark David V. , Kannappan Sheila J. , Eckert Kathleen D. , Florez Jonathan , Hall Kirsten R. , Watson Linda C. , Hoversten Erik A. , Burchett Joseph N. , Guynn David T. , Baker Ashley D. , Moffett Amanda J. , Berlind Andreas A. , Norris Mark A. , Haynes Martha P. , Giovanelli Riccardo , Leroy Adam K. , Pisano D. J. , Wei Lisa H. , Gonzalez Roberto E. , Calderon Victor F.
Published: November 2016

We present the H i mass inventory for the REsolved Spectroscopy Of a Local VolumE (RESOLVE) survey, a volume-limited, multi-wavelength census of >1500 z = 0 galaxies spanning diverse environments and complete in baryonic mass down to dwarfs of ∼109

. This first 21 cm data release provides robust detections or strong upper limits (1.4M
H i
 < 5%–10% of stellar mass M
*) for ∼94% of RESOLVE. We examine global atomic gas-to-stellar mass ratios (G/S) in relation to galaxy environment using several metrics: group dark matter halo mass M
h, central/satellite designation, relative mass density of the cosmic web, and distance to the nearest massive group. We find that at fixed M
*, satellites have decreasing G/S with increasing M
h starting clearly at M
h ∼ 1012

, suggesting the presence of starvation and/or stripping mechanisms associated with halo gas heating in intermediate-mass groups. The analogous relationship for centrals is uncertain because halo abundance matching builds in relationships between central G/S, stellar mass, and halo mass, which depend on the integrated group property used as a proxy for halo mass (stellar or baryonic mass). On larger scales G/S trends are less sensitive to the abundance matching method. At fixed M
h ≤ 1012

, the fraction of gas-poor centrals increases with large-scale structure density. In overdense regions, we identify a rare population of gas-poor centrals in low-mass (M
h < 1011.4

) halos primarily located within ∼1.5× the virial radius of more massive (M
h > 1012

) halos, suggesting that gas stripping and/or starvation may be induced by interactions with larger halos or the surrounding cosmic web. We find that the detailed relationship between G/S and environment varies when we examine different subvolumes of RESOLVE independently, which we suggest may be a signature of assembly bias.
ON THE CLASSIFICATION OF GRBs AND THEIR OCCURRENCE RATES
Authors: Ruffini R. , Rueda J. A. , Muccino M. , Aimuratov Y. , Becerra L. M. , Bianco C. L. , Kovacevic M. , Moradi R. , Oliveira F. G. , Pisani G. B. , Wang Y.
Published: November 2016

There is mounting evidence for the binary nature of the progenitors of gamma-ray bursts (GRBs). For a long GRB, the induced gravitational collapse paradigm proposes as progenitor, or “in-state,” a tight binary system composed of a carbon–oxygen core (CO

) undergoing a supernova explosion that triggers hypercritical accretion onto a neutron star (NS) companion. For a short GRB (S-GRB), an NS–NS merger is traditionally adopted as the progenitor. We divide long and S-GRBs into two subclasses, depending on whether or not a black hole (BH) is formed in the merger or in the hypercritical accretion process exceeding the NS critical mass. For long bursts, when no BH is formed, we have the subclass of X-ray flashes (XRFs), with isotropic energy

erg and rest-frame spectral peak energy

. When a BH is formed, we have the subclass of binary-driven hypernovae (BdHNe), with

erg and

. In analogy, short bursts are similarly divided into two subclasses. When no BH is formed, short gamma-ray flashes (S-GRFs) occur, with

erg and

. When a BH is formed, the authentic S-GRBs occur, with

erg and

. We give examples and observational signatures of these four subclasses and their rate of occurrence. From their respective rates it is possible that “in-states” of S-GRFs and S-GRBs originate from the “out-states” of XRFs. We indicate two additional progenitor systems: white dwarf–NS and BH–NS. These systems have hybrid features between long and short bursts. In the case of S-GRBs and BdHNe evidence is given of the coincidence of the onset of the high-energy GeV emission with the birth of a Kerr BH.
CONTACT BINARIES AS VIABLE DISTANCE INDICATORS: NEW, COMPETITIVE (V)JHKs PERIOD–LUMINOSITY RELATIONS
Authors: Chen Xiaodian , Grijs Richard de , Deng Licai
Published: November 2016

Based on the largest catalogs currently available, comprising 6090 contact binaries (CBs) and 2167 open clusters (OCs), we determine the near-infrared (NIR) JHK
s CB period–luminosity (PL) relations, for the first time achieving the low levels of intrinsic scatter that make these relations viable as competitive distance calibrators. To firmly establish our distance calibration on the basis of OC CBs, we require that (i) the CB of interest must be located inside the core radius of its host cluster, (ii) the CB’s proper motion must be located within the 2σ distribution of that of its host OC, and (iii) the CB’s age, t, must be comparable to that of its host cluster, i.e.,

. We thus select a calibration sample of 66 CBs with either OC distances or accurate space-based parallaxes. The resulting NIR PL relations, for both late-type (i.e., W Ursae Majoris-type) and—for the first time—early-type CBs, are as accurate as the well-established JHK
s Cepheid PL relations, (characterized by single-band statistical uncertainties of σ < 0.10 mag). We show that CBs can be used as viable distance tracers, yielding distances with uncertainties of better than 5% for 90% of the 6090 CBs in our full sample. By combining the full JHK
s photometric data set, CBs can trace distances with an accuracy, σ = 0.05 (statistical) ± 0.03 (systematic) mag. The 102 CBs in the Large Magellanic Cloud are used to determine a distance modulus to the galaxy of

mag.
A MACHINE LEARNS TO PREDICT THE STABILITY OF TIGHTLY PACKED PLANETARY SYSTEMS
Authors: Tamayo Daniel , Silburt Ari , Valencia Diana , Menou Kristen , Ali-Dib Mohamad , Petrovich Cristobal , Huang Chelsea X. , Rein Hanno , Laerhoven Christa van , Paradise Adiv , Obertas Alysa , Murray Norman
Published: November 2016

The requirement that planetary systems be dynamically stable is often used to vet new discoveries or set limits on unconstrained masses or orbital elements. This is typically carried out via computationally expensive N-body simulations. We show that characterizing the complicated and multi-dimensional stability boundary of tightly packed systems is amenable to machine-learning methods. We find that training an XGBoost machine-learning algorithm on physically motivated features yields an accurate classifier of stability in packed systems. On the stability timescale investigated (107 orbits), it is three orders of magnitude faster than direct N-body simulations. Optimized machine-learning classifiers for dynamical stability may thus prove useful across the discipline, e.g., to characterize the exoplanet sample discovered by the upcoming Transiting Exoplanet Survey Satellite. This proof of concept motivates investing computational resources to train algorithms capable of predicting stability over longer timescales and over broader regions of phase space.
FIRST GAIA LOCAL GROUP DYNAMICS: MAGELLANIC CLOUDS PROPER MOTION AND ROTATION
Authors: van der Marel Roeland P. , Sahlmann Johannes
Published: November 2016

We use the Gaia data release 1 (DR1) to study the proper motion (PM) fields of the Large and Small Magellanic Clouds (LMC, SMC). This uses the Tycho-Gaia Astrometric Solution (TGAS) PMs for 29 Hipparcos stars in the LMC and 8 in the SMC. The LMC PM in the West and North directions is inferred to be

, and the SMC PM

. These results have similar accuracy and agree to within the uncertainties with existing Hubble Space Telescope (HST) PM measurements. Since TGAS uses different methods with different systematics, this provides an external validation of both data sets and their underlying approaches. Residual DR1 systematics may affect the TGAS results, but the HST agreement implies this must be below the random errors. Also in agreement with prior HST studies, the TGAS LMC PM field clearly shows the clockwise rotation of the disk, even though it takes the LMC disk in excess of 108 years to complete one revolution. The implied rotation curve amplitude for young LMC stars is consistent with that inferred from line of sight (LOS) velocity measurements. Comparison of the PM and LOS rotation curves implies a kinematic LMC distance modulus

, consistent but not yet competitive with photometric methods. These first results from Gaia on the topic of Local Group dynamics provide an indication of how its future data releases will revolutionize this field.
DETECTION OF A DEARTH OF STARS WITH ZERO ANGULAR MOMENTUM IN THE SOLAR NEIGHBORHOOD
Authors: Hunt Jason A. S. , Bovy Jo , Carlberg Raymond G.
Published: November 2016

We report on the detection in the combined Gaia-DR1/RAVE data of a lack of disk stars in the solar neighborhood with velocities close to zero angular momentum. We propose that this may be caused by the scattering of stars with very low angular momentum onto chaotic, halo-type orbits when they pass through the Galactic nucleus. We model the effect in a Milky Way–like potential and fit the resulting model directly to the data, finding a likelihood (

) of a dip in the distribution. Using this effect, we can make a dynamical measurement of the solar rotation velocity around the Galactic center:

. Combined with the measured proper motion of Sgr A*, this measurement gives a measurement of the distance to the Galactic center:

.