bluuebunny/crossref_metadata_2025 huggingface dataset:
Proteolytic Volatile Profile and Electrophoretic Analysis of Casein Composition in Milk and Cheese Derived from Mironutrient-Fed Cows
Authors: Ianni Andrea , Bennato Francesca , Martino Camillo , Grotta Lisa , Franceschini Nicola , Martino Giuseppe
Published: May 2020

The aim of the study was to evaluate the proteolytic process in Caciocavallo cheese obtained from Friesian cows fed zinc, selenium, and iodine supplementation. Thirty-six Friesian cows, balanced for parity, milk production, and days in milk, were randomly assigned to four groups. The control group (CG) was fed with a conventional feeding strategy, while the three remaining groups received a diet enriched with three different trace elements, respectively zinc (ZG), selenium (SG), and iodine (IG). At the end of the experimental period, samples of milk were collected and used to produce Caciocavallo cheese from each experimental group. Cheese samples were then analyzed after 7 and 120 days from the cheese making in order to obtain information on chemical composition and extent of the proteolytic process, evaluated through the electrophoretic analysis of caseins and the determination of volatiles profile. Both milk and cheese samples were richer in the amount of the microelement respectively used for the integration of the cattle’s diet. The zymographic approach was helpful in evaluating, in milk, the proteolytic function performed by endogenous metalloenzymes specifically able to degrade gelatin and casein; this evaluation did not highlight significant differences among the analyzed samples. In cheese, the electrophoretic analysis in reducing and denaturing condition showed the marked ability of β-casein to resist the proteolytic action during ripening, whereas the dietary selenium supplementation was shown to perform a protective action against the degradation of S1 and S2 isoforms of α-casein. The analysis of the volatile profile evidenced the presence of compounds associated with proteolysis of phenylalanine and leucine. This approach showed that selenium was able to negatively influence the biochemical processes that lead to the formation of 3-methyl butanol, although the identification of the specific mechanism needs further investigation.
Wide-Antimicrobial Spectrum of Picolinium Salts
Authors: Salajkova Sarka , Benkova Marketa , Marek Jan , Sleha Radek , Prchal Lukas , Malinak David , Dolezal Rafael , Sepčić Kristina , Gunde-Cimerman Nina , Kuca Kamil , Soukup Ondrej
Published: May 2020

Nosocomial infections, which greatly increase morbidity among hospitalized patients, together with growing antibiotic resistance still encourage many researchers to search for novel antimicrobial compounds. Picolinium salts with different lengths of alkyl chains (C12, C14, C16) were prepared by Menshutkin-like reaction and evaluated with respect to their biological activity, i.e., lipophilicity and critical micellar concentration. Picolinium salts with C14 and C16 side chains achieved similar or even better results when in terms of antimicrobial efficacy than benzalkoniums; notably, their fungicidal efficiency was substantially more potent. The position of the methyl substituent on the aromatic ring does not seem to affect antimicrobial activity, in contrast to the effect of length of the N-alkyl chain. Concurrently, picolinium salts exhibited satisfactory low cytotoxicity against mammalian cells, i.e., lower than that of benzalkonium compounds, which are considered as safe.
Surface Modification of Magnetic Nanoparticles by Carbon-Coating Can Increase Its Biosafety: Evidences from Biochemical and Neurobehavioral Tests in Zebrafish
Authors: Malhotra Nemi , Audira Gilbert , Chen Jung-Ren , Siregar Petrus , Hsu Hua-Shu , Lee Jiann-Shing , Ger Tzong-Rong , Hsiao Chung-Der
Published: May 2020

Recently, magnetic nanoparticles (MNPs) have gained much attention in the field of biomedical engineering for therapeutic as well as diagnostic purposes. Carbon magnetic nanoparticles (C-MNPs) are a class of MNPs categorized as organic nanoparticles. C-MNPs have been under considerable interest in studying in various applications such as magnetic resonance imaging, photothermal therapy, and intracellular transportof drugs. Research work is still largely in progress for testing the efficacy of C-MNPs on the theranostics platform in cellular studies and animal models. In this study, we evaluated the neurobehavioral toxicity parameters on the adult zebrafish (Danio rerio) at either low (1 ppm) or high (10 ppm) concentration level of C-MNPs over a period of two weeks by waterborne exposure. The physical properties of the synthesized C-MNPs were characterized by transmission electron microscopy, Raman, and XRD spectrum characterization. Multiple behavior tests for the novel tank, mirror biting, predator avoidance, conspecific social interaction, shoaling, and analysis of biochemical markers were also conducted to elucidate the corresponding mechanism. Our data demonstrate the waterborne exposure of C-MNPs is less toxic than the uncoated MNPs since neither low nor high concentration C-MNPs elicit toxicity response in behavioral and biochemical tests in adult zebrafish. The approach combining biochemical and neurobehavioral approaches would be helpful for understanding C-MNPs association affecting the bioavailability, biosafety, interaction, and uptake of these C-MNPs in the living organism.
Panax quinquefolium L. Ginsenosides from Hairy Root Cultures and Their Clones Exert Cytotoxic, Genotoxic and Pro-Apoptotic Activity towards Human Colon Adenocarcinoma Cell Line Caco-2
Authors: Kochan Ewa , Nowak Adriana , Zakłos-Szyda Małgorzata , Szczuka Daria , Szymańska Grażyna , Motyl Ilona
Published: May 2020

American ginseng, Panax quinquefolium (L.), is traditionally used in folk medicine. It exhibits a range of anti-inflammatory, hepatoprotective, anti-diabetic, anti-obesity, anti-hyperlipidemic and anti-carcinogenic effects. Its main components are ginsenosides, also known as panaxosides or triterpene saponins. In order to obtain high yields of ginsenosides, different methods of controlled production are involved, i.e., with hairy root cultures. However, they are still employed under in vitro conditions. Our studies revealed that hairy root cultures subjected to an elicitation process can be considered as a potent source of ginsenosides. The present study examines the biological activity of ginseng hairy root cultures against the Caco-2 human adenocarcinoma cell line. Among our six different clones of P. quinquefolium hairy roots, extracts B and Be (treated with elicitor) were the strongest inhibitors of the cellular metabolic activity. While all extracts induced DNA damage, B and Be also generated reactive oxygen species (ROS) in a concentration-dependent manner, which was correlated with the depletion of the mitochondrial membrane potential and induction of apoptosis. These findings indicate that further research concerning P. quinquefolium hairy root cultures should focus on the activity of rare ginsenosides and other biologically active compound profiles (i.e., phenolic compounds).
Predicting Drug Resistance Using Deep Mutational Scanning
Authors: Pines Gur , Fankhauser Reilly G. , Eckert Carrie A.
Published: May 2020

Drug resistance is a major healthcare challenge, resulting in a continuous need to develop new inhibitors. The development of these inhibitors requires an understanding of the mechanisms of resistance for a critical mass of occurrences. Recent genome editing technologies based on high-throughput DNA synthesis and sequencing may help to predict mutations resulting in resistance by testing large mutagenesis libraries. Here we describe the rationale of this approach, with examples and relevance to drug development and resistance in malaria.
Recent Advances in Polymer Nanomaterials for Drug Delivery of Adjuvants in Colorectal Cancer Treatment: A Scientific-Technological Analysis and Review
Authors: Osorio Marlon , Martinez Estefanía , Naranjo Tonny , Castro Cristina
Published: May 2020

Colorectal cancer (CRC) is the type with the second highest morbidity. Recently, a great number of bioactive compounds and encapsulation techniques have been developed. Thus, this paper aims to review the drug delivery strategies for chemotherapy adjuvant treatments for CRC, including an initial scientific-technological analysis of the papers and patents related to cancer, CRC, and adjuvant treatments. For 2018, a total of 167,366 cancer-related papers and 306,240 patents were found. Adjuvant treatments represented 39.3% of the total CRC patents, indicating the importance of adjuvants in the prognosis of patients. Chemotherapy adjuvants can be divided into two groups, natural and synthetic (5-fluorouracil and derivatives). Both groups can be encapsulated using polymers. Polymer-based drug delivery systems can be classified according to polymer nature. From those, anionic polymers have garnered the most attention, because they are pH responsive. The use of polymers tailors the desorption profile, improving drug bioavailability and enhancing the local treatment of CRC via oral administration. Finally, it can be concluded that antioxidants are emerging compounds that can complement today’s chemotherapy treatments. In the long term, encapsulated antioxidants will replace synthetic drugs and will play an important role in curing CRC.
Chemical Kinetic Model of Multicomponent Gasoline Surrogate Fuel with Nitric Oxide in HCCI Combustion
Authors: Yang Chao , Zheng Zhaolei
Published: May 2020

This study presents a simplified mechanism of a five-component gasoline surrogate fuel (TDRF–NO) that includes n-heptane, isooctane, toluene, diisobutylene (DIB) and nitric oxide (NO). The mechanism consists of 119 species and 266 reactions and involves TDRF and NO submechanisms. Satisfactory results were obtained in simulating HCCI combustion in engines. The TDRF submechanism is based on the simplified mechanism of toluene reference fuel (TRF) and adds DIB to form quaternary surrogate fuel for gasoline. A simplified NO submechanism containing 33 reactions was added to the simplified mechanism of TDRF, considering the effect of active molecular NO on the combustion of gasoline fuel. The ignition delay data of the shock tube under different pressure and temperature conditions verified the validity of the model. Model verification results showed that the ignition delay time predicted by the simplified mechanism and its submechanics were consistent with the experimental data. The addition of NO caused the ignition delay time of the mechanism simulation to advance with increasing concentration of NO added. The established simplified mechanism effectively predicted the actual combustion and ignition of gasoline.
Lipoteichoic Acid Biosynthesis Inhibitors as Potent Inhibitors of S. aureus and E. faecalis Growth and Biofilm Formation
Authors: Naclerio George A. , Onyedibe Kenneth I. , Sintim Herman O.
Published: May 2020

Methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis (VRE) have been deemed as serious threats by the CDC. Many chronic MRSA and VRE infections are due to biofilm formation. Biofilm are considered to be between 10–10,000 times more resistant to antibiotics, and therefore new chemical entities that inhibit and/or eradicate biofilm formation are needed. Teichoic acids, such as lipoteichoic acids (LTAs) and wall teichoic acids (WTAs), play pivotal roles in Gram-positive bacteria’s ability to grow, replicate, and form biofilms, making the inhibition of these teichoic acids a promising approach to fight infections by biofilm forming bacteria. Here, we describe the potent biofilm inhibition activity against MRSA and VRE biofilms by two LTA biosynthesis inhibitors HSGN-94 and HSGN-189 with MBICs as low as 0.0625 µg/mL against MRSA biofilms and 0.5 µg/mL against VRE biofilms. Additionally, both HSGN-94 and HSGN-189 were shown to potently synergize with the WTA inhibitor Tunicamycin in inhibiting MRSA and VRE biofilm formation.
Trinuclear NiII-LnIII-NiII Complexes with Schiff Base Ligands: Synthesis, Structure, and Magnetic Properties
Authors: Georgopoulou Anastasia N. , Pissas Michael , Psycharis Vassilis , Sanakis Yiannis , Raptopoulou Catherine P.
Published: May 2020

The reaction of the Schiff base ligand o-OH-C6H4-CH=N-C(CH2OH)3, H4L, with Ni(O2CMe)2·4H2O and lanthanide nitrate salts in a 4:2:1 ratio lead to the formation of the trinuclear complexes [Ni2Ln(H3L)4(O2CMe)2](NO3) (Ln = Sm (1), Eu (2), Gd (3), Tb (4)). The complex cations contain the strictly linear NiII-LnIII-NiII moiety. The central LnIII ion is bridged to each of the terminal NiII ions through two deprotonated phenolato groups from two different ligands. Each terminal NiII ion is bound to two ligands in distorted octahedral N2O4 environment. The central lanthanide ion is coordinated to four phenolato oxygen atoms from the four ligands, and four carboxylato oxygen atoms from two acetates which are bound in the bidentate chelate mode. The lattice structure of complex 4 consists of two interpenetrating, supramolecular diamond like lattices formed through hydrogen bonds among neighboring trinuclear clusters. The magnetic properties of 1–4 were studied. For 3 the best fit of the magnetic susceptibility and isothermal M(H) data gave JNiGd = +0.42 cm−1, D = +2.95 cm−1 with gNi = gGd = 1.98. The ferromagnetic nature of the intramolecular Ni···Gd interaction revealed ground state of total spin S = 11/2. The magnetocaloric effect (MCE) parameters for 3 show that the change of the magnetic entropy (−ΔSm) reaches a maximum of 14.2 J kg−1 K−1 at 2 K. A brief literature survey of complexes containing the NiII-LnIII-NiII moiety is discussed in terms of their structural properties.
Enhanced Microwave Absorption Bandwidth in Graphene-Encapsulated Iron Nanoparticles with Core–Shell Structure
Authors: Zhang Danfeng , Deng Yunfei , Han Congai , Zhu Haiping , Yan Chengjie , Zhang Haiyan
Published: May 2020

Graphene-encapsulated iron nanoparticles (Fe(G)) hold great promise as microwave absorbers owing to the combined dielectric loss of the graphene shell and the magnetic loss of the ferromagnetic metal core. Transmission electron microscopy (TEM) revealed transition metal nanoparticles encapsulated by graphene layers. The microwave electromagnetic parameters and reflection loss (R) of the Fe(G) were investigated. Graphene provided Fe(G) with a distinctive dielectric behavior via interfacial polarizations taking place at the interface between the iron cores and the graphene shells. The R of Fe(G)/paraffin composites with different Fe(G) contents and coating thickness was simulated according to the transmit-line theory and the measured complex permittivity and permeability. The Fe(G)/paraffin composites showed an excellent microwave absorption with a minimum calculated R of −58 dB at 11 GHz and a 60 wt% Fe(G) loading. The composites showed a wide bandwidth (the bandwidth of less than −10 dB was about 11 GHz). The R of composites with 1–3 mm coating thickness was measured using the Arch method. The absorption position was in line with the calculated results, suggesting that the graphene-coated iron nanoparticles can generate a suitable electromagnetic match and provide an intense microwave absorption. Excellent Fe(G) microwave absorbers can be obtained by selecting optimum layer numbers and Fe(G) loadings in the composites.
Photonic and Thermal Modelling of Microrings in Silicon, Diamond and GaN for Temperature Sensing
Authors: Weituschat Lukas Max , Dickmann Walter , Guimbao Joaquín , Ramos Daniel , Kroker Stefanie , Postigo Pablo Aitor
Published: May 2020

Staying in control of delicate processes in the evermore emerging field of micro, nano and quantum-technologies requires suitable devices to measure temperature and temperature flows with high thermal and spatial resolution. In this work, we design optical microring resonators (ORRs) made of different materials (silicon, diamond and gallium nitride) and simulate their temperature behavior using several finite-element methods. We predict the resonance frequencies of the designed devices and their temperature-induced shift (16.8 pm K−1 for diamond, 68.2 pm K−1 for silicon and 30.4 pm K−1 for GaN). In addition, the influence of two-photon-absorption (TPA) and the associated self-heating on the accuracy of the temperature measurement is analysed. The results show that owing to the absence of intrinsic TPA-processes self-heating at resonance is less critical in diamond and GaN than in silicon, with the threshold intensity I th = α / β , α and β being the linear and quadratic absorption coefficients, respectively.
Dietary Antioxidant Intake and Human Papillomavirus Infection: Evidence from a Cross-Sectional Study in Italy
Authors: Barchitta Martina , Maugeri Andrea , La Mastra Claudia , La Rosa Maria Clara , Favara Giuliana , Magnano San Lio Roberta , Agodi Antonella
Published: May 2020

Several lines of evidence suggested that antioxidants might play a protective role against high-risk human papillomavirus (hrHPV) infection and cervical cancer. However, the effect of combined intake of antioxidants has not been investigated thus far. The current cross-sectional study aimed to understand the relationship between dietary antioxidant intake and the risk of high-risk HPV (hrHPV) infection among 251 Italian women with normal cervical cytology. Women were tested for hrHPV using the Digene HC2 HPV DNA Test. Dietary antioxidant intakes were assessed using a semi-quantitative food frequency questionnaire, and a Composite Dietary Antioxidant Index (CDAI) was constructed on the basis of zinc, selenium, manganese, vitamin A, vitamin C, vitamin E, carotenoid, and flavonoid intake. Logistic regression analysis was used to assess odds ratio (OR) and 95% confidence interval (95% CI) for the associations of antioxidant intakes or CDAI with hrHPV status, adjusting for age, smoking status, body mass index, parity, educational level, marital status, and use of multivitamins and oral contraceptives. We first observed that hrHPV-positive women (n = 84) reported lower intake of zinc, manganese, and vitamins A and C than non-infected women. Specifically, we found a negative association between dietary intake of zinc and hrHPV-positive status when all antioxidants were considered simultaneously (OR = 0.46; 95% CI = 0.27–0.80; p = 0.006). With respect to cumulative dietary antioxidant intake, we demonstrated that women with high CDAI (third tertile) had lower odds of being hrHPV-positive than those with low CDAI (first tertile) (OR = 0.39; 95% CI = 0.18–0.85; p = 0.018). To our knowledge, this is the first study demonstrating that a diet based on the combined intake of nutrients with antioxidant properties might reduce the risk of hrHPV infection. However, further research is needed to understand whether dietary antioxidant intake is associated with hrHPV infection or its persistence.
Vitamin D Status and Its Determinants in a Paediatric Population in Norway
Authors: Holten-Andersen Mads N , Haugen Johanne , Oma Ingvild , Strand Tor A
Published: May 2020

Recommendations for sufficient vitamin D intake in children were recently revised in Norway. However, optimal levels of vitamin D are still debated and knowledge on supplementation and vitamin D levels in healthy children in Norway is scarce. Therefore, we measured the plasma-concentration of 25-hydroxyvitamin D (25(OH)D) in children and adolescents attending the outpatient paediatric clinics in Innlandet Hospital Trust, Norway during two consecutive years (2015–2017). We recruited 301 children and adolescents aged 5 months to 18 years (mean 7.8, SD 4.4 years) for the study and obtained sample material for 25(OH)D measurements from 295 (98%). Information on diet, vitamin D supplementation, sun exposure, ethnicity, parental education and general health was collected by questionnaire. 25(OH)D levels were analysed and determinants for 25(OH)D were estimated by linear regression. 1.0% of the children had deficient levels (25(OH)D < 25 nmol/L) and 21.0% had insufficient levels (25–50 nmol/L). 25(OH)D levels ranging from 50 to 75 nmol/L were found among 38.3%, while 39.7% had levels above 75 nmol/L. The mean 25(OH)D level was 70.0 nmol/L (SD 23.4, range 17–142 nmol/L) with a significant seasonal variation with lowest levels in mid-winter and highest in late summer. In addition to seasonal variation independent determinants for 25(OH)D-levels were age of the child, parental ethnicity, vitamin D supplementation and soda consumption. Along with parental ethnicity other than Nordic, age was the strongest determinant of 25(OH)D, with adolescents having the lowest levels.
Apple Flavonols Mitigate Adipocyte Inflammation and Promote Angiogenic Factors in LPS- and Cobalt Chloride-Stimulated Adipocytes, in Part by a Peroxisome Proliferator-Activated Receptor-γ-Dependent Mechanism
Authors: Liddle Danyelle M. , Kavanagh Meaghan E. , Wright Amanda J. , Robinson Lindsay E.
Published: May 2020

Adipose tissue (AT) expansion induces local hypoxia, a key contributor to the chronic low-grade inflammation that drives obesity-associated disease. Apple flavonols phloretin (PT) and phlorizin (PZ) are suggested anti-inflammatory molecules but their effectiveness in obese AT is inadequately understood. Using in vitro models designed to reproduce the obese AT microenvironment, 3T3-L1 adipocytes were cultured for 24 h with PT or PZ (100 μM) concurrent with the inflammatory stimulus lipopolysaccharide (LPS; 10 ng/mL) and/or the hypoxia mimetic cobalt chloride (CoCl2; 100 μM). Within each condition, PT was more potent than PZ and its effects were partially mediated by peroxisome proliferator-activated receptor (PPAR)-γ (p < 0.05), as tested using the PPAR-γ antagonist bisphenol A diglycidyl ether (BADGE). In LPS-, CoCl2-, or LPS + CoCl2-stimulated adipocytes, PT reduced mRNA expression and/or secreted protein levels of inflammatory and macrophage chemotactic adipokines, and increased that of anti-inflammatory and angiogenic adipokines, which was consistent with reduced mRNA expression of M1 polarization markers and increased M2 markers in RAW 264.7 macrophages cultured in media collected from LPS + CoCl2-simulated adipocytes (p < 0.05). Further, within LPS + CoCl2-stimulated adipocytes, PT reduced reactive oxygen species accumulation, nuclear factor-κB activation, and apoptotic protein expression (p < 0.05). Overall, apple flavonols attenuate critical aspects of the obese AT phenotype.
Cytokine-Induced Killer (CIK) Cells, In Vitro Expanded under Good Manufacturing Process (GMP) Conditions, Remain Stable over Time after Cryopreservation
Authors: Mareschi Katia , Adamini Aloe , Castiglia Sara , Rustichelli Deborah , Castello Laura , Mandese Alessandra , Leone Marco , Pinnetta Giuseppe , Mesiano Giulia , Ferrero Ivana , Fagioli Franca
Published: May 2020

Cytokine-induced killer (CIK) cells are advanced therapy medicinal products, so their production and freezing process has to be validated before their clinical use, to verify their stability as a drug formulation according to the good manufacturing practice (GMP) guidelines. We designed a stability program for our GMP-manufactured CIK cells, evaluating the viability, identity and potency of cryopreserved CIK cells at varying time periods from freezing, and compared them with fresh CIK cells. We evaluated the effects of the cryopreservation method, transportation, and the length of time of different process phases (pre-freezing, freezing and post-thawing) on the stability of CIK cells. This included a worst case for each stage. The expanded CIK cells were viable for up to 30 min from the addition of the freezing solution, when transported on dry ice within 48 h once frozen, within 60 min from thawing and from 12 months of freezing while preserving their cytotoxic effects. The reference samples, cryopreserved simultaneously in tubes and following the same method, were considered representative of the batch and useful in the case of further analysis. Data obtained from this drug stability program can inform the accurate use of CIK cells in clinical settings.
Systematic Studies on Surface Erosion of Photocrosslinked Polyanhydride Tablets and Data Correlation with Release Kinetic Models
Authors: Geraili Armin , Mequanint Kibret
Published: May 2020

Photocrosslinkable polyanhydrides that undergo surface erosion are suitable materials for controlled-release drug delivery systems. Investigating the impact of different parameters on their erosion behavior is essential before use in drug delivery systems. Although their synthesis is well-established, parameters that may substantially affect the erosion of thiol-ene polyanhydrides including temperature and pH of the media, the geometry of the polymers, and the media shaking rate (the convective force for the polymer erosion), have not yet been studied. This study explores the effects of different environmental and geometric parameters on mass loss (erosion) profiles of polyanhydrides synthesized by thiol-ene photopolymerization. A comparative study on several release kinetic models fitting is also described for a better understanding of the polymer erosion behavior. The results demonstrated that although the temperature was the only parameter that affected the induction period substantially, the mass-loss rate was influenced by the polymer composition, tablet geometry, temperature, pH, and mass transfer (shaking) rate. With regard to geometrical parameters, polymers with the same surface area to volume ratios showed similar mass loss trends despite their various volumes and surface areas. The mass loss of polyanhydride tablets with more complicated geometries than a simple slab was shown to be non-linear, and the kinetic model study indicated the dominant surface erosion mechanism. The results of this study allow for designing and manufacturing efficient delivery systems with a high-predictable drug release required in precision medicine using surface-erodible polyanhydrides.
Facile Synthesis of Phosphorus and Cobalt Co-Doped Graphitic Carbon Nitride for Fire and Smoke Suppressions of Polylactide Composite
Authors: Cao Xianwu , Chi Xiaoning , Deng Xueqin , Sun Qijun , Gong Xianjing , Yu Bin , Yuen Anthony Chun Yin , Wu Wei , Li Robert Kwow Yiu
Published: May 2020

Due to the unique two-dimensional structure and features of graphitic carbon nitride (g-C3N4), such as high thermal stability and superior catalytic property, it is considered to be a promising flame retardant nano-additive for polymers. Here, we reported a facile strategy to prepare cobalt/phosphorus co-doped graphitic carbon nitride (Co/P-C3N4) by a simple and scalable thermal decomposition method. The structure of Co/P-C3N4 was confirmed by scanning electron microscopy (SEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). The carbon atoms in g-C3N4 were most likely substituted by phosphorous atoms. The thermal stability of polylactide (PLA) composites was increased continuously with increasing the content of Co/P-C3N4. In contrast to the g-C3N4, the Polylactide (PLA) composites containing Co/P-C3N4 exhibited better flame retardant efficiency and smoke suppression. With the addition of 10 wt % Co/P-C3N4, the peak heat release rate (PHRR), carbon dioxide (CO2) production (PCO2P) and carbon oxide (CO) production (PCOP) values of PLA composites decreased by 22.4%, 16.2%, and 38.5%, respectively, compared to those of pure PLA, although the tensile strength of PLA composites had a slightly decrease. The char residues of Co/P-C3N4 composites had a more compact and continuous structure with few cracks. These improvements are ascribed to the physical barrier effect, as well as catalytic effects of Co/P-C3N4, which inhibit the rapid release of combustible gaseous products and suppression of toxic gases, i.e., CO.
Synthesis of Nixantphos Core-Functionalized Amphiphilic Nanoreactors and Application to Rhodium-Catalyzed Aqueous Biphasic 1-Octene Hydroformylation
Authors: Joumaa Ahmad , Gayet Florence , Garcia-Suarez Eduardo J. , Himmelstrup Jonas , Riisager Anders , Poli Rinaldo , Manoury Eric
Published: May 2020

A latex of amphiphilic star polymer particles, functionalized in the hydrophobic core with nixantphos and containing P(MAA-co-PEOMA) linear chains in the hydrophilic shell (nixantphos-functionalized core-crosslinked micelles, or nixantphos@CCM), has been prepared in a one-pot three-step convergent synthesis using reversible addition-fragmentation chain transfer (RAFT) polymerization in water. The synthesis involves polymerization-induced self-assembly (PISA) in the second step and chain crosslinking with di(ethylene glycol) dimethacrylate (DEGDMA) in the final step. The core consists of a functionalized polystyrene, obtained by incorporation of a new nixantphos-functionalized styrene monomer (nixantphos-styrene), which is limited to 1 mol%. The nixantphos-styrene monomer was synthesized in one step by nucleophilic substitution of the chloride of 4-chloromethylstyrene by deprotonated nixantphos in DMF at 60 °C, without interference of either phosphine attack or self-induced styrene polymerization. The polymer particles, after loading with the [Rh(acac)(CO)2] precatalyst to yield Rh-nixantphos@CCM, function as catalytic nanoreactors under aqueous biphasic conditions for the hydroformylation of 1-octene to yield n-nonanal selectively, with no significant amounts of the branched product 2-methyl-octanal.
ROSACE: A Proposed European Design for the Copernicus Ocean Colour System Vicarious Calibration Infrastructure
Authors: Antoine David , Vellucci Vincenzo , Banks Andrew C. , Bardey Philippe , Bretagnon Marine , Bruniquel Véronique , Deru Alexis , Hembise Fanton d’Andon Odile , Lerebourg Christophe , Mangin Antoine , Crozel Didier , Victori Stéphane , Kalampokis Alkiviadis , Karageorgis Aristomenis P. , Petihakis George , Psarra Stella , Golbol Melek , Leymarie Edouard , Bialek Agnieszka , Fox Nigel , Hunt Samuel , Kuusk Joel , Laizans Kaspars , Kanakidou Maria
Published: May 2020

The European Copernicus programme ensures long-term delivery of high-quality, global satellite ocean colour radiometry (OCR) observations from its Sentinel-3 (S3) satellite series carrying the ocean and land colour instrument (OLCI). In particular, the S3/OLCI provides marine water leaving reflectance and derived products to the Copernicus marine environment monitoring service, CMEMS, for which data quality is of paramount importance. This is why OCR system vicarious calibration (OC-SVC), which allows uncertainties of these products to stay within required specifications, is crucial. The European organisation for the exploitation of meteorological satellites (EUMETSAT) operates the S3/OLCI marine ground segment, and envisions having an SVC infrastructure deployed and operated for the long-term. This paper describes a design for such an SVC infrastructure, named radiometry for ocean colour satellites calibration and community engagement (ROSACE), which has been submitted to Copernicus by a consortium made of three European research institutions, a National Metrology Institute, and two small- to medium-sized enterprises (SMEs). ROSACE proposes a 2-site infrastructure deployed in the Eastern and Western Mediterranean Seas, capable of delivering up to about 80 high quality matchups per year for OC-SVC of the S3/OLCI missions.
Does Adoption of Ridehailing Result in More Frequent Sustainable Mobility Choices? An Investigation Based on the National Household Travel Survey (NHTS) 2017 Data
Authors: Das Vivekananda
Published: May 2020

Among many changes potentially induced by the adoption of ridehailing, one key area of interest in transportation and urban planning research is how these services affect sustainable mobility choices, such as usage of public transit, walking, and biking modes and lower ownership of household vehicles. In this study, by using subsamples of the National Household Travel Survey (NHTS) 2017 data, propensity score matching technique is applied to generate matched samples of ridehailing adopters and non-adopters from ten different core-based statistical areas in the U.S. Results from multivariable count data regression models built on the matched samples indicate that, on average, the count of public transit trips is greater for adopters compared against identical non-adopters in all ten areas. Regarding average counts of walking and biking trips, adopters tend to make more trips in most of the places, although a few exceptions are also found. However, the relationship between ridehailing adoption and count of household vehicles appears to be more complicated as adopters, on average, seem to have a lower or higher number of vehicles than identical non-adopters, depending on the area. One major limitation of this study is that, in the statistical analyses, effects of attitudinal and detailed geographic variables are not directly controlled for, which complicates causal interpretations of findings.
Hybrid Renewable Energy Microgrid for a Residential Community: A Techno-Economic and Environmental Perspective in the Context of the SDG7
Authors: Kumar Nallapaneni Manoj , Chopra Shauhrat S. , Chand Aneesh A. , Elavarasan Rajvikram Madurai , Shafiullah G.M.
Published: May 2020

Energy, being a prime enabler in achieving sustainable development goals (SDGs), should be affordable, reliable, sustainable, and modern. One of the SDGs (i.e., SDG7) suggests that it is necessary to ensure energy access for all. In developing countries like India, the progress toward SDG7 has somewhat stagnated. The aging conventional electric power system has its dominant share of energy from fossil fuels, plagued with frequent power outages, and leaves many un-electrified areas. These are not characteristics of a sustainable and modern system in the context of the SDG7. Promoting renewable-based energy systems, especially in the context of microgrids (MGs), is one of the promising advances needed to rejuvenate the progress toward the SDG7. In this context, a hybrid renewable energy microgrid (HREM) is proposed that gives assurance for energy access to all in an affordable, reliable, and sustainable way through modern energy systems. In this paper, a techno-economic and environmental modeling of the grid-independent HREM and its optimization for a remote community in South India are presented. A case of HREM with a proposed configuration of photovoltaic/wind turbine/diesel generator/battery energy storage system (PV/WT/DG/BESS) was modeled to meet the community residential electric load requirements. This investigation dealt with the optimum sizes of the different components used in the HREM. The results of this model presented numerous feasible solutions. Sensitivity analysis was conducted to identify the best solution from the four optimized results. From the results, it was established that a PV + DG + BESS based HREM was the most cost-effective configuration for the specific location. In addition, the obtained optimum solutions were mapped with the key criteria of the SDG7. This mapping also suggested that the PV + DG + BESS configuration falls within the context of the SDG7. Overall, it is understood that the proposed HREM would provide energy access to households that is affordable, reliable, sustainable, and modern.
Envisioning Tourism and Proximity after the Anthropocene
Authors: Rantala Outi , Salmela Tarja , Valtonen Anu , Höckert Emily
Published: May 2020

The current Earthly crisis demands new imaginings, conceptualisations and practices of tourism. This paper develops a post-anthropocentric approach to envisioning the possibilities of the ‘proximate’ in tourism settings. The existing generic definitions of proximity tourism refer to a form of tourism that emphasises local destinations, short distances and lower-carbon modes of transport, as well as the mundane exceptionality of the ordinary. We conceptualise proximity tourism with feminist new materialist literature, which accords agency to the ongoing common worlding of all matter—including but not limited to humans—rather than to separate individual agents. More specifically, our research explores the idea of proximity by drawing closer to the geo—to the Earth—through geological walks in the Pyhä National Park in Finnish Lapland. We analyse these walks with the notions of rhythmicity, vitality and care—ideas constructed from the theoretical heritage guiding our study. By doing this, we explore the potential of proximity tourism in ways that intertwine non-living and living matter, science stories, history, local communities and tourism. The outcome of this analysis, we propose, composes one possible narrative of tourism after the Anthropocene.
Eradication and Control Strategies for Red Imported Fire Ants (Solenopsis invicta) in Taiwan
Authors: Liu Helen K. , Lin Chung-Chi , Huang Li-Hsin , Huang Sin-An , Huang Rong-Nan
Published: May 2020

Invasive alien species are one of the major threats to biological diversity, public safety, agriculture, and economics. In recent years, a new wave of the red imported fire ant (RIFA) has been detected in new regions, including Kobe (Japan), Daegu (South Korea), Kaohsiung (Taiwan), and other locations in southeast Asia. Due to the increasing number of invasions, practitioners and scientists are seeking effective strategies to respond to RIFA invasions in Pacific regions, especially in countries that have had no presence of RIFA. This study aims to identify the strategies adopted to eradicate RIFA in Taiwan and to elucidate some of the assumptions about RIFA prevention and treatment in infested areas with diverse land patterns. Through a literature review and examination of eradication cases in Taiwan, five essential eradication lessons are discussed: (1) Immediate action through partnership with universities and the private sector; (2) engagement with the public and community with an interest in RIFA control through technology; (3) establishment of multi-level horizontal networks of response teams; (4) strategy implementation ranging from large-scale prevention to precise treatment; and (5) adoption of technology and social media. These strategies will have implications and applications for east and south Asian countries that are dealing with similar challenges.
Predicting Financial Distress of Slovak Enterprises: Comparison of Selected Traditional and Learning Algorithms Methods
Authors: Gregova Elena , Valaskova Katarina , Adamko Peter , Tumpach Milos , Jaros Jaroslav
Published: May 2020

Predicting the risk of financial distress of enterprises is an inseparable part of financial-economic analysis, helping investors and creditors reveal the performance stability of any enterprise. The acceptance of national conditions, proper use of financial predictors and statistical methods enable achieving relevant results and predicting the future development of enterprises as accurately as possible. The aim of the paper is to compare models developed by using three different methods (logistic regression, random forest and neural network models) in order to identify a model with the highest predictive accuracy of financial distress when it comes to industrial enterprises operating in the specific Slovak environment. The results indicate that all models demonstrated high discrimination accuracy and similar performance; neural network models yielded better results measured by all performance characteristics. The outputs of the comparison may contribute to the development of a reputable prediction model for industrial enterprises, which has not been developed yet in the country, which is one of the world’s largest car producers.
Exploring the Relationships between the Topological Characteristics of Subway Networks and Service Disruption Impact
Authors: Wang Zhiru , Ma Wubin , Chan Albert
Published: May 2020

Although numerous studies have considered the topological characteristics and the impact of disruptions in subway systems, their results have not been verified by empirical data. To address this limitation, we used a data set containing 392 detailed records of disruptions to subway services in Beijing from 2011 to 2017. The Spearman rank correlation coefficient analysis results indicate that the delay duration exhibits no significant relationship with the topological characteristics, whereas the reverse is true for the relationship between the number of affected trains and the topological characteristics. The results also demonstrate that subway network expansion will not result in a paradox between convenience and vulnerability from an actual data perspective. Moreover, contrary to previous research results, no significant relationship was found to exist between service interruption impact and the transit and key bridge stations. However, a high degree of clustering, characterized by redundant tracks between neighbours, tends to provide protection against service disruption for stations. In terms of the spatial variation, the influence of the disruption is greater when the station is further from the centre of the line. These results can support sustainable design in subway network planning.
Formulation Matters! The Failure of Integrating Landscape Fragmentation Policy
Authors: Aubrechtová Tereza , Semančíková Eva , Raška Pavel
Published: May 2020

Uncoordinated land development results in landscape fragmentation, which is a complex and serious environmental threat to the Czech landscape. It poses a challenge especially for (post)industrial urban agglomerations with extremely low connectivity of green–blue infrastructure. Environmental and spatial planning strategic policy documents are considered to represent long-term communicative instruments for effective environmental protection. Current experience shows that policy documents are commonly poorly integrated, and burdened by formulation inconsistencies. In this study, we (i) specified the driving factors causing landscape fragmentation, describing how the issue is understood by environmental and spatial planning strategic policy documents and (ii) identified criteria for the formulation of these documents at the national and regional governance levels. A content analysis of 12 strategic policy documents enabled the calculation of internal consistency and an assessment of their inter- and cross-sectoral integration. The results revealed formulation flaws in documents, leading to serious misunderstandings of the meaning of the landscape fragmentation between environmental (biocentric) and planning (anthropocentric) policy domains. This aspect makes the horizontal and further vertical cooperation between policy domains difficult. Guidelines for the formulation of strategic policy documents may improve their intelligibility and support smoother environmental policy integration.
Use of Information and Communication Technologies (ICTs) in Communication and Collaboration: A Comparative Study between University Students from Spain and Italy
Authors: Llorent-Vaquero Mercedes , Tallón-Rosales Susana , de las Heras Monastero Bárbara
Published: May 2020

The aim of this study is to determine the level of competence that university students from Spain and Italy have in the use of Information and Communication Technologies (ICTs) for communication and collaboration purposes. We also intend to identify possible differences and similarities between both countries, as well as factors associated with their competence that may lead to a digital gap. In order to fulfil these objectives, we performed a positivist exploratory study based on a quantitative methodology supported by a descriptive method with a survey design. The data collection is performed with a questionnaire, the data from which are analyzed through two statistical studies: a descriptive one and a causal one. The results show good competence from the students in this area, being somewhat higher in Italian students. We identified some of the factors associated with competence, such as Internet access or having a tablet. In conclusion, it is clear that politics on a global, national and local level are essential to the acquisition of digital competence, especially regarding the digital gap caused by access to resources. In this sense, governments must guarantee free and universal access to technology to all their citizens in order to diminish the digital gap between them.
A Border Approximation Area Approach Considering Bipolar Neutrosophic Linguistic Variable for Sustainable Energy Selection
Authors: Rahim Nuraini , Abdullah Lazim , Yusoff Binyamin
Published: May 2020

In the last few decades, the computational methods under Multi-Criteria Decision-Making (MCDM) have experienced significant growth in research interests from various scientific communities. Multi-Attributive Border Approximation area Comparison (MABAC) is one of the MCDM methods where its computation procedures are based on distances and areas, and able to express a complex decision systematically. Previous literature have suggested the combination of MABAC with fuzzy sets, in which this combination is used to solve problems that are characterized by uncertain and incomplete information. Differently from the fuzzy MABAC, which directly used single membership, this paper proposes bipolar neutrosophic MABAC of which the positive and negative of truth, indeterminate and false memberships of bipolar neutrosophic set are introduced to enhance decision in sustainable energy selection. Fourteen criteria and seven alternatives of sustainable energy are the main MCDM structures that need to be solved using the proposed method. A group of experts were invited to provide rating of performance values of criteria and alternatives of sustainable energy problem using a bipolar neutrosophic linguistic scale. The distances of alternatives from the Border Approximation Area of bipolar neutrosophic MABAC are the main output of the proposed method prior to making the final decision. The computational results show that ‘Biomass’ is the optimal alternative to sustainable energy selection. Comparable results are also presented to check the consistency of the proposed method.
Price or Convenience: What Is More Important for Online and Offline Bookings? A Study of a Five-Star Resort Hotel in Taiwan
Authors: Teng Yi-Man , Wu Kun-Shan , Chou Che-Yi
Published: May 2020

Low price or convenience? What is more important for online and offline bookings? For the sustainable development of the hospitality industry, it is necessary to know the opinions of customers about their online/offline hotel booking experiences. This study aimed to predict the customers’ online/offline booking behavior toward a resort hotel in Taiwan by adapting the marketing mix elements. We first designed and executed a detailed questionnaire involving approximately 300 respondents from a five-star hotel in Taiwan, used hypothesis testing to extract important factors from the data, and finally used logistic regression of these factors to predict the customer choices effectively. The study results show that the majority of the customers believe that booking hotel services online provides for a broader choice, offers more discounts and more privacy than available while booking offline, and is cheaper, faster, and more reliable and convenient. The outcomes of logistic regression confirm that “broad choice,” but not “low price” has the most significant impact on the customers booking a resort accommodation online or offline. Furthermore, the results of the analysis of variance (ANOVA) show that the younger customers (under the age of 45) and those with university degrees are significantly more likely to make the reservations online for a resort. The findings and the recommendations can provide valuable inputs to the resort industry practitioners in Taiwan for improving the online booking services.