bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of a Mitochondrial Membrane Permeability Transition Prognosis System in Colon Adenocarcinoma: Risk Stratification and Therapeutic Target Identification
Authors: Zhang Bomiao , Xia Mingyu , Zhao Shihui , Li Yien , Yu Chenfeng , Song Liqiang , Wang Shaoke , Cui Binbin
Published: October 2024

Aims:

Explore the role of mitochondrial membrane permeability transition
(MPT) in colon adenocarcinoma (COAD).

Background:

Further exploration of risk stratification for COAD prognostic assessment
has important clinical value. MPT-related pathways play a key role in the pathogenesis
of many human diseases, including tumorigenesis. Its impact on COAD is still unknown.

Objective:

Bioinformatics analysis was conducted by analyzing the GEO database and
TCGA database, and the bioinformatics results were verified by in vitro experiments.

Method:

Through the analysis of the transcriptome data of 1008 COAD samples in the
GEO database and TCGA database, the differential expressions of MPT-related genes in
COAD were explored, followed by molecular subtype analysis based on MPT characteristics
by univariate Cox algorithm analysis and the consensus clustering algorithm.
The gene signature associated with MPT molecular subtypes was further identified and
the MPT scoring system was established by the LASSO-univariate Cox analysis algorithm.
After evaluating the prognostic value of the MPT scoring system in COAD patients
via nomogram establishment, the clinical value of the MPT scoring system was
comprehensively analyzed through somatic mutation characteristics analysis, immunotherapy
response analysis, immunoinfiltration analysis, and drug sensitivity analysis.
CCK-8, WB, PCR, colony formation method, and Transwell method were used to
verify the effect of the screened target on the proliferation and invasion of COAD cells.

Result:

We successfully established a scoring system related to MPT and validated the
prognostic value of COAD patients. The potential clinical value of the MPT scoring system
was also analyzed. VSIG4 was selected for further in vitro experiments to verify the
effect of the screened targets on the proliferation and invasion ability of COAD cells.

Conclusions:

We established an MPT scoring system for effective risk stratification of
COAD patients, demonstrating the impact of MPT on the development of COAD and its
potential value as an intervention factor.
Jiangu Recipe Suppresses ER Stress-Induced Apoptosis and Inhibits Extracellular Matrix Degradation in Chondrocytes through Upregulating
SIRT1 Expression
Authors: Qiao Jie , Cheng Chang , Yang Gongxu , Zhong Chuanqi , Jin Jun , Wu Bin
Published: October 2024

Objective:

This study aimed to explore the effects of Jiangu Recipe (JGR) on chondrocyte
responses under tert-Butyl hydroperoxide (TBHP)-induced oxidative stress, specifically
focusing on apoptosis and extracellular matrix (ECM) degradation.

Methods:

Chondrocytes were treated with varying JGR concentrations, and cell viability was
assessed. The impact of JGR on TBHP-induced apoptosis and protein expression levels of apoptosis-
related molecules (Bcl-2, Bax, and cleaved caspase-3) and ECM components (Collagen II,
Aggrecan, MMP-13) was evaluated.

Results:

JGR exhibited protective effects against oxidative stress in chondrocytes. Moreover, it
maintained cell viability under tert-butyl hydroperoxide (TBHP) induction, suppressing apoptosis
(Bax, cleaved caspase-3) and enhancing anti-apoptotic Bcl-2. JGR also attenuated extracellular
matrix (ECM) degradation, promoting Collagen II and Aggrecan while reducing MMP-13
expression. Investigating endoplasmic reticulum (ER) stress, it was found that JGR downregulated
TBHP-induced GRP78, CHOP, ATF4, p-PERK, and p-eIF2α, thus indicating ER stress
modulation. SIRT1 played a key role, as JGR upregulated SIRT1, mitigating TBHP-induced
downregulation. SIRT1 knockdown reversed JGR's protective effects, highlighting its crucial
role in JGR-mediated responses.

Conclusion:

Our findings suggest that JGR mitigated TBHP-induced chondrocyte apoptosis and
ECM degradation, highlighting its potential therapeutic application in osteoarthritis. Mechanistically,
our study highlights that SIRT1 plays a crucial role in mediating the protective effects of
JGR against ER stress-induced chondrocyte apoptosis and ECM degradation, providing a foundation
for further clinical exploration in managing osteoarthritic conditions.
Multi-Stimuli-Responsive Biocompatible Magnetic Nanocarrier as Drug Delivery System to MCF-7 Breast Cancer Cells
Authors: Ehsanimehr Sedigheh , Badr Kimya , Dehaen Wim , Irannejad Vahid Shafiei , Moghadam Peyman Najafi
Published: October 2024

Introduction:

The last strategy in targeted drug delivery systems is to deliver the anticancer
drug to the tumor tissue to increase its therapeutic effect and minimize its undesirable side
effects. In line with this goal in this research, the redox/pH-responsive disulfide magnetic nanocarriers
based on PF127-NH2/L-cysteine-CM-β-CD-FA were synthesized and evaluated in a doxorubicin
delivery system.

Methods:

We effectively surrounded Fe3O4 nanoparticles with SiO2 using the sol-gel method, and
then confidently coated them with oleic acid on Fe3O4@SiO2 nanoparticles.. In another reaction, a
PF127-NH2/L-cysteine-CM-β-CD-FA was synthesized. The process involved modifying pluronic
F127 (PF 127) with maleic anhydride and aminating it to form PF127-NH2. The obtained PF127-NH2
was attached to L-cysteine, followed by condensing with carboxymethyl-β-cyclodextrin and then
functionalized by folic acid. Finally, PF127-NH2/L-cysteine-CM-β-CD-FA was coated on the surface
of magnetic nanoparticles, and the resulting PF127-NH2/L-cysteine-CM-β-CD-FA was disulfidated
to form the final nanocarrier network, which was abbreviated as LCMNPs-SS. The doxorubicin
was used as a model drug and loaded into the LCMNPs-SS nanocarrier.

Results:

The LCMNPs-SS nanocarrier exhibited excellent properties for controlled release, with a
well-defined release rate, a controllable level by an external magnet, and adjusting by DLdithiothreitol
concentration. The LCMNPs-SS nanocarrier could also break apart when exposed to an
oxidant or a change in pH. This meant that the drug release could be fine-tuned in response to temperature,
pH, or more than one stimulus.

Conclusion:

These drug-carrying systems are valuable in reducing the dose of doxorubicin. High
internalization of the synthesized LCMNPs-SS caused sped cellular uptake.
Approaches to Improve the Sleep Quality in Long Covid Patients: A Systematic Review
Authors: ShamsiKhani Soheila , Hosseini Mahsa
Published: October 2024

Background:

Given the high prevalence of Long COVID, sleep problems have
emerged as a significant issue for individuals after COVID-19 infection, potentially impacting
their quality of life.

Objective:

Our study aims to identify effective strategies for improving sleep quality and offers recommendations
for future research.

Methods:

The present systematic review study investigated ways to improve sleep quality in
Long COVID patients. The study was conducted according to the updated PRISMA guidelines.
The risk of bias was assessed using ROB 2.0.

Results:

Finally, six articles were included in the present study to identify strategies for improving
and enhancing sleep quality in Long COVID. The results of the present study indicate that
various interventions have been carried out to improve sleep quality, including psychological, cognitive,
and physical factors related to long-term COVID-19 conditions.

Conclusion:

Based on existing evidence, interventions such as mind meditation, yoga, and hyperbaric
oxygen therapy have demonstrated efficacy in enhancing sleep quality among Long COVID
patients.
Bioactive Formulation and Bulk Allopurinol and Lycopene Estimation by UV Spectroscopy
Authors: Mishra Soumya , Harwansh Ranjit K. , Mazumder Rupa
Published: October 2024

Background:

This study developed a UV spectrophotometric method for quantifying allopurinol and lycopene in both bulk and dosage forms, aiming for simplicity and practicality.

Materials and Methods:

The method was developed and validated using methanol and lyco-pene in phosphate buffer saline at various pH levels (7.4, 6.8, 1.2, 5.5). Validation parameters included linearity, accuracy, precision, limit of quantification (LOQ), and limit of detection (LOD) according to ICH standards.

Results:

The method demonstrated high sensitivity and linearity over a concentration range of 4-20 μg/ml, adhering to Beer's law. The LOQ and LOD were 2–18 μg/ml and 2–6 μg/ml, re-spectively. Optimal absorbance wavelengths were 251 nm for lycopene and 471 nm for allopu-rinol. Calibration curves showed a high correlation coefficient (0.9994), indicating a strong lin-ear relationship.

Conclusion:

The developed UV spectrophotometric method is effective, interference-free, and suitable for routine quality control, providing reliable measurements for allopurinol and lyco-pene.
Fixed Prosthodontic Rehabilitation of a Patient with Cleidocranial Dysplasia: A Case Report
Authors: Karakaya Merve , Çötert İrem , Yücel İrem Nur , Çötert H. Serdar
Published: October 2024

Introduction

Cleidocranial Dysplasia (CCD) is a rare congenital disease characterized by skeletal and dental anomalies. Clinical findings of CCD patients include low facial height, pseudoprognathism, unerupted teeth, an excessive deep bite, chewing difficulties, and unsatisfied dentofacial appearance. These patients’ dental treatments present a substantial challenge.

Case Representation

This case report describes the prosthodontic treatment of a 29-year-old male CCD patient using porcelain-fused-to-metal restorations. The avoidance of a surgical procedure serves to minimize the potential for complications and expedites the attainment of outcomes with greater celerity. Throughout the follow-up period of 1 year, the patient maintained good periodontal health. The restoration of masticatory function and enhancement of facial esthetics were successfully achieved and the patient expressed a high degree of satisfaction with the outcome of the treatment.

Conclusion

The use of fixed prostheses in CCD patients is a treatment modality that resolves many of the issues caused by the surgical approach.
Quantitative Assessments of the Liquefaction Hazard of Soils considering Possible Strong Earthquakes in Seismically Active Regions of Russia
Authors: Zaalishvili Vladislav B. , Chernov Yuri.K. , Chernov Andrey Yu
Published: October 2024

Introduction

The seismogenic liquefaction of the soil poses a great hazard to society and the environment. Therefore, it is actively studied in many countries. In Russian engineering and seismological practice, this area is not sufficiently developed. The deterministic approach still prevails in Russian research on this topic. More modern probabilistic estimates are very rare.

Methods

This paper describes examples of both deterministic and probabilistic assessments of the seismogenic liquefaction hazard performed in certain areas of the Russian territory with different seismogeological conditions. Deterministic estimates were made using the Iwasaki-Seed-Finn methods and their modifications. Probability distribution functions of a random variable, the “seismic potential of liquefaction” (SPL), were developed for probabilistic estimates. These functions are regional in nature and take into account two types of uncertainties. The first is the uncertainty in achieving “critical” values by the SPL value in the event of potentially dangerous earthquake sources for a given location. The second is the uncertainty in the very occurrence of these sources in a given place for a given period of time. The “critical” SPL values are determined by the strength properties of the site soils. All estimates are based on multivariate calculations using various models of strong ground motions and seismicity. In all cases, the probability of liquefaction of water-saturated sandy and sandy-loam deposits was estimated which were found near the seabed and at depths of up to 80 m in the waters of Pogibi cape (the coast of Sakhalin island), in the districts of Sochi and Novorossiysk, as well as in land conditions (Stavropol, Krasnodar).

Results

The results of the research made it possible to correctly (at the quantitative level) take into account this component of the seismic hazard of the studied territories.

Conclusion

The variants of practical use of the obtained data are offered. An assessment of the possibilities and limitations of the developed methodology is made, and ways to improve it are outlined.
Investigating the Status of Mothers and Newborns' Access to Safe and Quality Care from the Perspective of Midwifery Personnel Working in Government Hospitals: A Cross-Sectional Study
Authors: Jamei Zahra , Sayedi Javad , Shaye Zahra Abbasi , Raesi Rasoul
Published: October 2024

Aim

The present study was conducted to determine the status of mothers’ and newborns' access to safe and quality care from the perspective of midwifery personnel.

Background

Safe and quality care is recognized as a principle in providing healthcare to mothers and newborns.

Methods

This was a cross-sectional study conducted through random sampling on 270 midwifery personnel working in government hospitals of Mashhad University of Medical Sciences in 2023. The data were collected using a questionnaire created by a researcher and analyzed using descriptive and inferential statistical tests in SPSS-22 statistical software at a significance level of less than 0.05.

Results

The average age of the participants was 34.41 ± 7.93 years. The results showed the status of mothers' and newborns' access to safe and quality care to be in the average range of 38.30 ± 6.67. The midwifery personnel have demonstrated adherence to scientific and specialized protocols regarding the way for childbirth and how to care for mothers and newborns to be the most frequent (51.5%), while the provision of emotional and psychological support to women who have given birth with newborn problems to be the least frequent (8.5%).

Conclusion

Midwifery personnel believe that the safe and quality care provided to mothers and newborns is adequate. Midwifery personnel are committed to following evidence-based practices, but need additional training and resources to support women in need emotionally and psychologically. This is particularly concerning given the potential impact of maternal mental health on both the mother and the newborn.
Incorporation of Silica Nanoparticles in Dental Stone Type IV: Effects on Setting Time
Authors: Fahimi Mahsa , Torab Ali , Mahboub Farhang , Rezaei Yashar , Haji Jafarabadi Sara , Radesh Parsa , Dizaj Solmaz Maleki
Published: October 2024

Introduction:

This study aimed to examine the setting time of dental stone type IV by
adding different percentages (0.5, 1, 2, 5) of silica nanoparticles.

Materials and Methods:

In this in vitro study, silica nanoparticles (silicon dioxide) were added to
dental stone type IV at concentrations of 0.5%, 1%, 2%, and 5% by weight. Forty samples were divided
into five groups: 0.5%, 1%, 2%, 5%, and a control group. The samples were prepared according
to the manufacturer's instructions and tested according to the ISO 6873 standard using a
Vicat device. The time from the start of mixing until the needle could no longer fully penetrate the
mass was measured using a chronometer, and the setting time was recorded. Quantitative data
were described using mean and standard deviation, and a one-way ANOVA test was performed using
SPSS 26 to compare the results. A significance level of P < 0.05 was set.

Results:

The addition of silica nanoparticles to dental stone type IV significantly increased the setting
time, with the increase being proportional to the concentration of the nanoparticles. The setting
time of the group containing 5% nanoparticles was significantly higher than that of the control
and the 0.5% group (P value < 0.05).

Conclusion:

The incorporation of silica nanoparticles into dental stone type IV resulted in a significant
increase in setting time, particularly at a concentration of 5%. This increase is within the ISO
range and offers advantages in the use of nanoparticles in dental materials.
Emerging Nanoparticle-Based Herbal Drug Delivery Systems for Colon Targeting Therapy
Authors: Shree Dipthi , Patra Chinam Niranjan , Sahoo Biswa Mohan
Published: October 2024

Herbal medications hold a dominant position in the pharmaceutical sector due to
their well-established therapeutic effects and extremely low negative effects. Besides, herbal
remedies are easily available and highly economical. However, to circumvent the issue of
poor bioavailability, the combinatorial strategy of incorporating herbal medicines and nanotechnology
is useful. The phytoconstituents molded in novel nanocarriers such as polymeric
nanoparticles, polymeric micelles, liposomes, solid lipid nanoparticles, nanostructured lipid
carriers, nanoemulsions, gold nanoparticles, etc., have been extensively investigated as they
are the most promising approach for colon-targeting drug delivery systems. Although plantbased
medicines have been developed for decades, there is enormous research interest in the
development of an effective plant-derived delivery system for the incorporation of phytoconstituents
into various nanomaterials to overcome potential challenges related to solubility,
bioavailability, and stability issues. The encapsulation of phytoconstituents in a novel
nanocarrier is a promising approach to improving the bioavailability, stability, and therapeutic
efficacy of herbal medicines. The herbal nanomedicines are used as a promising tool for targeted
delivery to the colon, with potentially effective outcomes for the treatment of colonic
diseases, viz., ulcerative colitis, diverticulitis, Crohn's disease, shigellosis, constipation, colonic
polyps, colon cancer, etc. This article presents a comprehensive survey of recent findings
and patents by innovators working exclusively on nanoparticles for the delivery of phytomedicines
for colon targeting.
Utilizing Ecological Momentary Assessment to Record Changes in E-cigarettes and Combustible Cigarette Use: Results From a Pilot Randomized Clinical Trial (Preprint)
Authors: Morgan Tuker , He Michelle , Nicholson Andrew , Sherman Scott , Stevens Elizabeth
Published: October 2024

BACKGROUND

Background: Ecological momentary assessment (EMA) provides insight into the effectiveness and feasibility of smoking-related interventions.

OBJECTIVE

To assessed adherence to an EMA protocol and compared EMA-derived responses to survey data.

METHODS

Data were from a two-arm pilot randomized clinical trial among adult smokers with a chronic condition (n=109). EMA data were collected via SMS prompts sent to participants four times daily for 12 weeks. Convergent validity between survey- and EMA-reported measures was evaluated using Pearson correlation and paired differences. Cigarettes per day (CPD) was modeled using negative binomial regression. Relative rates (RR) of 50%, 75%, and 100% CPD reduction were calculated.

RESULTS

The majority of participants were non-Hispanic White (58%) with median age of 60 (IQR 54-65). Median weekly EMA response rate was high (week 1, 98%; week 12, 89%). EMA and survey CPD measurements were positively correlated (r = 0.73; CI 0.60, 0.82) as were measures of craving (r = 0.38; CI 0.17, 0.56). No significant paired difference in CPD was observed. A significant effect of time on CPD EMA data (Incidence rate ratio (IRR) 1-week change = 0.93, p<0.01) and survey data was found (IRR 12-week change = 0.36, p < 0.01).

CONCLUSIONS

EMA is a suitable method to collect recall-based smoking data. Though results from mixed effect modeling and RR comparisons were similar using EMA or survey data, EMA provides unique advantages, namely greater granularity in the time and the capability to detect switching patterns in near real-time.
Patient Education in Bariatric Surgery: Can Artificial Intelligence-based Chatbots Bridge the Knowledge Gap? (Preprint)
Authors: Izadi Amirreza , Mosavari Hesam , Hosseininasab Ali , Jaliliyan Ali , Jafari Arzhang , Akhlaghpasand Mohammadhosein , Rostami Aghil , Moradi-Lakeh Maziar , Eghbali Foolad
Published: October 2024

BACKGROUND

The global obesity epidemic continues to pose significant health challenges, with an increasing number of individuals seeking Metabolic and Bariatric Surgery (MBS), particularly laparoscopic sleeve gastrectomy (LSG). However, many MBS centers face resource limitations that limit the availability of adequate patient education, leading to knowledge gaps among patients who require more information. This consequently leads patients to seek information online increasingly. Artificial intelligence (AI) based chatbots like ChatGPT offer a promising tool to provide reliable and accessible medical information. However, concerns about the accuracy, reliability, and comprehensiveness of AI-generated responses still need to be addressed.

OBJECTIVE

This study aims to evaluate the effectiveness of AI-based chatbots in answering frequently asked patient questions about LSG and compare their performance with that of bariatric surgery experts.

METHODS

The study included four fellowship-trained minimally invasive surgeons (MISs), nine minimally invasive surgery fellows (MIFs), and two general practitioners (GPs) involved in MBS multidiciplinary team, forming the expert group. Seven AI chatbots, including ChatGPT versions 3.5 and 4, Bard, Bing, Claude, Llama, and Perplexity, were selected based on public availability. Forty patient questions about LSG were derived from social media, MBS organizations, and online patient forums. Experts and chatbots answered these questions, and their responses were scored for accuracy and comprehensiveness using a 5-point scale. Statistical analyses were performed to compare group performance.

RESULTS

Chatbots demonstrated a higher overall performance score (2.55 ± 0.95) compared to the expert group (1.92 ± 1.32, P < .001). Among chatbots, ChatGPT-4 achieved the highest performance (2.94 ± 0.24), while Llama had the lowest (2.15 ± 1.23). Expert group scores were highest for MISs (2.36 ± 1.09), followed by GPs (1.90 ± 1.36) and MIFs (1.75 ± 1.36). The readability of chatbot responses was assessed using Flesch-Kincaid scores, revealing that most responses required reading levels between the 11th grade and college level. Furthermore, chatbots exhibited fair reliability and reproducibility in response consistency, with ChatGPT-4 showing the highest test-retest reliability.

CONCLUSIONS

AI-based chatbots provide reliable and comprehensive answers to common patient questions about LSG. These chatbots could play a significant role in patient education. Still, concerns over AI limitations, including readability and the potential for misinformation, must be addressed to ensure effective integration into healthcare.
Stimulant medication is not associated with increased cheating during online task performance: A field study (Preprint)
Authors: Yechiam Eldad , Zeif Dana
Published: October 2024

BACKGROUND

Performance-related cheating is a common psychological side effect in settings where task attention is enhanced, for instance, through incentives. However, only a single previous study found a positive effect of stimulants commonly used to elevate attention in attention-deficit/hyperactivity disorder on cheating.

OBJECTIVE

In a field study, we examined whether methylphenidate (MPH) and mixed amphetamine salts (MAS) increased prohibited usage of Internet resources during the performance of judgment and knowledge tasks.

METHODS

The participants were 656 US and Canada residents recruited via Prolific Academic who indicated using either MPH or MAS on a weekly basis. Among them 352 were medicated and 304 were unmedicated when performing the experimental tasks. We tested whether participants showed better performance in a version of the Cognitive Reflection Test where solutions are accessible online; and whether they answered a difficult knowledge question based on online resources.

RESULTS

There was a significant crossover interaction in both cheating paradigms, such that those medicated with MPH exhibited lower cheating than those unmedicated, while those medicated with MAS indicated a slight reverse effect, yet both medications did not evidence a simple effect of medication. There was also no effect or interaction of ADHD diagnosis.

CONCLUSIONS

We find no evidence for the positive effect of MPH on cheating observed previously, and instead find a trend in the reverse direction (Cohen’s d = -0.31), which also sheds light on the heterogeneity in the effect of MPH on performance.
La diversidad inexplorada de las algas rojas continentales: algunos datos actuales y perspectivas de futuro.
Authors: Aboal Marina
Published: October 2024

Las algas rojas continentales, frecuentemente asociadas a condiciones prístinas, han sido poco estudiadas en general, con la excepción de algunos países, y en muchos casos están condenadas a desaparecer con su hábitat. Algunos de sus géneros aparecen recogidos en todas las monografías ficológicas, pero de la mayoría existen muy escasos datos. Recientemente se ha comprobado la enorme diversidad genómica existente en los grupos de organismos más sencillos, que son los que hicieron la transición al medio continental. Los datos genómicos deberían complementarse con estudios morfológicos, ecológicos y fisiológicos detallados que permitan complementar el cuadro de la diversidad. Con el ejemplo de los avances en el estudio del grupo en la península Ibérica se resalta la importancia de infraestructuras como los herbarios y de la indispensable colaboración entre instituciones e investigadores.
Las macroalgas marinas y el cambio climático
Authors: Quiroz-González Nataly , Acosta-Calderón Julio A. , Mateo-Cid Luz Elena
Published: October 2024

El cambio climático global está generando afectaciones importantes en los organismos que habitan los ambientes marinos, las macroalgas presentan cambios en su metabolismo, fenología y distribución que se han estudiado con más frecuencia en tiempos recientes debido a la tropicalización de las zonas templadas y polares, cambios en el pH de los océanos y su consecuente acidificación. El presente trabajo ofrece un panorama general del impacto del cambio climático en las macroalgas marinas, así como de algunas de las adaptaciones que estas han desarrollado para su sobrevivencia.
Fragility curves of a slender structure fitted with tuned mass dampers subjected to turbulent wind and seismic loading
Authors: Pozos Estrada Adrián , Martín del Campo Preciado Jesús Osvaldo , Pozos Estrada Oscar
Published: October 2024

In the context of structural performance assessment, several studies have employed fragility curves and surfaces to evaluate the damage probability for predefined intensity levels of a single or multiple hazards. Further, some of these studies have considered the use of tuned mass dampers (TMDs) to reduce the response of structures under wind or seismic loading. In this work, fragility curves and surfaces of a slender structure fitted with TMDs subjected to turbulent wind and seismic loading alone and simultaneously are developed. For the numerical analyses, simulated records for wind and earthquake ground motion are considered. For the development of fragility curves and surfaces, three damage states that include local and global behavior of the structure are considered. The analysis results indicate that, for the structure considered, higher probability of damage is found from wind action than from earthquake, and that an important reliability enhancement is achieved with the use of TMDs.
Circulación y distribución de la masa de agua en el Golfo de México
Authors: Ichiye T.
Published: October 2024

Se analizan los datos oceanográficos colectados por el "Alaska" y el "Jakulla" en el Golfo de México, entre 1951 y 1955. La circulación de la capa superior se encuentra grandemente influenciada por el empuje del viento, como lo muestra la ubicación de agua de baja salinidad. Según el cambio estacional de temperatura y salinidad, Ia masa de agua en Ia capa superior se clasifica en cinco tipos: tres costeros y dos en altamar. Las correlaciones estadísticas T-S densidad-oxígeno y densidad-fosfatos muestran pequeña diferencia entre las partes occidental y oriental en Ia capa a mayor profundidad de 1,000 m. En Ia capa intermedia, sin embargo, Ia diferencia entre ambas partes se hace más clara debido a Ia penetración de agua en la sección oriental a través del Canal de Yucatán. Se encuentran remolinos anticiclónicos semi-permanentes en Ia parte oriental sobre una topografía dinámica, superficies sigma-t y normas isotérmicas a 200 m de profundidad. Estos vórtices parecen estar en contacto, de manera ocasional, con el escurrimiento a través del Canal de Yucatán. Una comparación con el Mar de Japón sugiere que Ia convección vertical es más intensa en ese mar, cuya masa de agua de naturaleza uniforme se extiende ampliamente en las capas intermedia y profunda. Tres problemas dinámicos se discuten en los apéndices. Primeramente, el empuje del viento en una cuenca circular con plataforma se deduce y aplica al Golfo de México. Los resultados indican que hay bastante acuerdo con el cambio estacional observado en la circulación de Ia capa superior del Golfo de México, manifestada por normas de isohalinas. En segundo lugar, los perfiles verticales de la temperatura y salinidad en la capa superior son explicados por soluciones de la ecuación de difusión de remolinos y advección de calor y masa de agua. En tercer lugar, se discuten los meandros de la Corriente de Yucatán y la estabilidad horizontal de los remolinos.
Methods and Algorithms for Searching Similarities between Texts
Authors: Yannikov I. M. , Ershova M. V. , Isenbaev A. N.
Published: October 2024

The review of the analytical article is a comprehensive study of text analysis modern methods in order to identify and measure the degree of their similarity, which itself is a very important and relevant task, since it examines and analyzes the tools used to solve it. The introduction discusses the purpose of this work, the relevance of the problem, and the importance of developing effective methods for comparing texts. The main part of the article examines and analyzes such methods as “jaccard similarity”, “shingle algorithm”, “levenshtein distance”, “tf-idf” and “bm25”, “bert” and the use of neural networksseparately. The application of a particular method is illustrated by examples presented in tabular form and illustrations. When considering and analyzing the “jaccard similarity”, the methods of its application and limitations are considered. When analyzing the “shingles algorithm”, the advantages of the method in the context of similarity search are revealed. The publication discusses methods based on line spacingin detail, including levenshtein distance. In this case, special attention is paid to the scope of its application and its advantages over other methods. By reviewing statistical methods such as 'tf-idf' and 'bm25', theanalysis of their application and effectiveness in text similaritysearching is given. The article is not limited by analyzing only traditional methods, but it also covers modern ones, including 'bert' and the use of neural networks. These methods are compared with each other, their advantages and disadvantages of use are identified. The conclusion section provides a comparative analysis of all presented methods based on the principle of objectivity, highlighting their characteristics and areas of application. The importance of choosing the most appropriate method for text similaritysearching is noted, depending on the specific search goals, tasks and requirements, and a conclusion is given about the most used, vast and productive method i.e. The use of neural networks. The conclusions emphasize that the article, devoted to a comparative analysis of various methods for similarity searching between texts, has the main goal of developing recommendations to choose the optimal method.
Automatic Search for a Solution in the Information Management System to Monitor the State of the Production Environment
Authors: Shevnina Yu. S.
Published: October 2024

The article presents a method for monitoring and managing the state of a production environment based on an information management system with an automatic solution search module using a hybrid neural network. The object of the study is the state of the production environment. Monitoring and management are carried out on the basis of predicting changes within the environment state, taking into account the interdependence of the measured parameters. In addition to the task of regulating the value of the controlled parameter, there is an additional task of automatically compiling a control program depending on external parametersprovided by this method of monitoring and control. To do this, an automatic solution search device with software based on neural networks is installed in a closed control loop. This device analyzes many parameters of the production environment and supplies the control device with the required value of the controlled parameter. To analyze dependencies between parameters and predict the state of the production environment, a neural network is used, the weights and biases of which are calculated using the harmonic search algorithm; training was carried out with the gradient descent algorithm. To assess the accuracy and stability of the automatic search for solutions in the information management system for monitoring the state of the production environment, an experiment was conducted, the results of which made it possible to obtain the parameters of the hybrid model. Further study of the obtained parameters showed that its use in the control loop of the information system for monitoring the state of the production environment makes it possible to provide a high-quality and stable forecast of changes in the state of the production environment. The proposed method made it possible to obtain stable operation of the information and control system for monitoring the state of the production environment and maintaining controlled parameters within the acceptable range.
Two-element Selective Assembly with Non-linear Input-output Models Using Approximation
Authors: Filipovich O.V.
Published: October 2024

The process of single-parameter selective assembly of two elements is considered for the case of a nonlinear input-output modelapplication. Due to the objective complexity of determining the relations between the limit deviations and tolerances of input and output parameters, as well as the relative accuracy smallness due to the precision of the assembly, it is reasonable to represent the initial model in the form of a first-order polynomial of two variables. Linearisation is proposed to be carried out using a method of obtaining an approximating relation in the form of a Taylor series and by means of a multivariate least square method, with subsequent variantcomparison according to a given criterion. The criterion for choosing one of the two proposed variants is the minimum average approximation error. To determine the values of group tolerances, it is proposed to use two methods: assigning the equal tolerances and assigning tolerances of the equal relative accuracy. For both methods the derivation of the set-making equations is given, allowing the use of selective group numbersunder certain assumptions. Using a linearized model, the main indicators of the assembly process are determined: the number of assembly sets, work in progress and preliminary scrap. An example is given for the case when the output parameter represents the product of the input elementparameters. The coefficients were calculated and the set-making equation was derived. Comparison of the results presented in the paper with earlier obtained results (initial nonlinear model) shows a relatively small divergence in calculating the boundaries of selective groups, the error in determining the probability of obtaining assembly sets as a whole does not exceed 0.5%. The proposed method is applicable in case of small values of relative accuracy of input and output parameters, which in practice corresponds to selective assembly of precision products.
The Concept of Building an Integrated Digital Ecosystem to Improve the Quality of Products and Services of Defense Industry Enterprises
Authors: Shcheglov D.K. , Saybel A.G.
Published: October 2024

Research and development of systems for managing material, technical, and intellectual resources are key directions for improving manufacturing processes in the modern world. In recent years, the question of integrating various management systems has become particularly relevant due to the widespread adoption of quality management systems and their certification to meet current regulatory requirements. This study attempts to merge the advantages of using product lifecycle information support technologies, such as data and information management, with the concept of digital twins, including virtual design, digital product modeling, and real-time analysis. The analysis covers the constituent elements of the generalized product design and manufacturing process, addressing the construction of an integrated digital ecosystem to enhance the quality of products and services in the defense-industrial complex. This ecosystem is based on the integration of technologies for continuous product information support using their digital twins and an integrated quality management system. It is shown that the approach to evaluating the effectiveness of purposeful processes should be complemented by a risk-oriented model, which includes response scenarios to potential adverse effects of the operation of the purposeful organizational-technical system. A structural scheme and formalized description of a generalized product information support model are presented, allowing for the integration of specific quality indicators into a unified strategic outcome. Ultimately, a concept for building an integrated digital ecosystem for defense-industrial enterprises is proposed, aimed at enhancing the overall quality of products and services.
Software System SPDIAL
Authors: Trubachev E.S.
Published: October 2024

Spiroid gears are direct competitors to traditional technical solutions - worm and hypoid gears; and they have proven themselves in a large number of specific technical applications, providing greater strength, smaller size, and easier production. However, their design process is much less subject to being typical and standard and to resulting in simple engineering techniques. In fact, effective solutions can be obtained only by actually researching the space of parameters. An indispensable tool for this is a computer-aided design and research system. The paper presents the summary of such a system SPDIAL+ for worm-type gears (worm, QN-gears, spiroid) developed at Izhevsk scientific school in the field of gears and gearboxes. In particular, the possibilities of designing a conjugated gear, choice of gearwheel cutting parameters, analysis of gears under the action of errors and loads are considered. The role and results of applying the program as the main tool for research, design and innovations like new varieties of gears, their new properties in specific applications, new methods and techniques of tooth machining are shown.
Analysis of the List of Risks Affecting the Verification of Measuring Instruments
Authors: Gumirov I.S. , Sopin V.F. , Denicova Ya.V.
Published: October 2024

The purpose of this study is to identify and analyze the risks accompanying the process of verification of measuring instruments in metrological services. Risks are analyzed within the framework of a holistic risk and opportunity management system aimed at identifying and managing potential threats and opportunities affecting the achievement of the ultimate goals of the organization. Risk is defined as a possible negative event that could affect project performance and is evaluated by probability of occurrence and possible consequences. The objectives of risk and opportunity management are aimed at ensuring the achievement of the capabilities of the metrology service under conditions of uncertainty. Effective risk assessment of the process of verification of measuring instruments requires a comprehensive approach. In this regard, in the course of the study the regulatory framework was considered, regulating activities in the field of ensuring the uniformity of measurements, identified internal and external environmental factors affecting the process of verification of measuring instruments, identified stakeholders in the field of metrology services. Procedures for risk identification, analysis, assessment and management have been developed within the system. The list of typical risks and opportunities in the process of verification of measuring instruments in the relationship with environmental factors and possible consequences for the organization is compiled. The developed list of potential risks and opportunities is typical for the process of verification of measuring instruments and therefore can be recommended to employees of metrological services of enterprises. With its help it is possible to assess in advance the potential risks and opportunities in the metrological field and to achieve a more effective result by minimizing the negative consequences.
Adaptive Matching of Discrete Antenna Tuning Units of High Frequency Band to Varying Load Impedance
Authors: Izvolsky A.A.
Published: October 2024

The issue of matching the antenna with thetransmitter-receiverplays a primary role in radio communications. The matching problem is relevant for different ranges and is solved in many ways. In the high frequency wave range, matching has a number of features when using an antenna coupler based on discrete elements consisting of capacitance and inductance boxes. The article discusses the concept of fast matching of high-frequency amplifying paths ofdecametric wavestransceivers with non-stationary loads using discrete antenna couplers. An innovative approach has been developed to the tuning process when changing the operating frequency and ensuring self-adaptation of the antenna coupler when changing the impedance, based on methods for quickly searching for the geometric proximity of points. A quick method for configuring the antenna coupler is proposed, eliminating the procedure for recalculating the input impedance based on the results of measuring the input impedance of the antenna coupler. When using it, the speed of setting the antenna coupler at the current operating frequency is limited only by the time of a single state change of the discrete power circuit, which in the case of electromagnetic relays is numerically equal to their switching time. The configuration of the antenna coupler using the method of fast search for the geometric proximity of points is based on a set of frequency cards with settings options. Such cards can be recalculated for the reference plane between the generator and the antenna coupler input for all combinations of discrete elements in accordance with the known matrix model of a discrete power circuit. This eliminates the complicated procedure of recalculating the input impedance of the antenna using complex numbers. The technical result of the proposed innovative method of antenna coupler configuringis simplification, tracking of systematic errors of the impedance meter, elimination of time-consuming calculations with complex numbers, expansion of the method functionality, reduction of the tuning duration and improvement its quality. The practical significance lies in the fact that the implementation of the proposed technical solutions in the high frequency range communications means can significantly (about 100 times) limit the duration of preparation for a radio communication session, eliminate the procedure for recalculating the antenna input impedance and reduce the resource requirements of switching elements.
Experimental Evaluation of the Possibility of Through Defects Detection in Thermally Expanded Graphite Workpieces by Acoustic Method
Authors: Bogdan O.P. , Blinova A.V. , Denisov L.A.
Published: October 2024

The paper presents the results of evaluating the possibility of detecting defects (e.g., through holes) in workpieces made of thermally expanded graphite used as sealing materials using a non-contact air-coupled acoustic inspection system. The deviation of the acoustic signal amplitude when it passes through a sample of thermally expanded graphite in defective and defect-free regions is used as an informative parameter. The obtained dependences of the change in the amplitude of the passed signal through the sample on the size of the artificial through hole, density and thickness of the object showed a significant influence of these parameters on the detectability of the defect, which should be taken into account in the development of inspection technologies and in the process of its implementation. The change in the amplitude of the signal passed through the object directly depends on the increase in the parameters of the sample (density, thickness) and the size of the through hole, which increases the sensitivity of acoustic control and detectability of defects.On the basis of the obtained dependences the criteria for rejection of workpieces can be developed at the stage of production or immediately before manufacturing of their products. The influence of defect positioning relative to the acoustic axis of the transmitter-receiver system is shown, which leads to a decrease in the informative parameter, and consequently to a decrease in sensitivity. This dependence is characteristic for all thicknesses and densities of objects, as well as for all sizes of artificial through holes when control is carried out immediately after defect formation. When acoustic inspection is carried out some time after the defect formation, the maximum of this dependence may shift due to the shift of the amount of substance to fill the defect cavity, which is confirmed by microscopy. The obtained results can be used in the development of workpieces acoustic control parameters.
Construcción de un modelo hidrológico e hidráulico (1D/2D) para el análisis de inundaciones urbanas en Cúcuta, Colombia
Authors: Sanchez-Tapiero Diego Ivan , Bonilla-Granados Carlos Alexis , Ramón-Valencia Jarol Derley
Published: October 2024

Comprender el comportamiento de las ciudades ante eventos de inundaciones se ha convertido en uno de los principales desafíos para los responsables de la toma de decisiones y planificadores urbanos en todo el mundo. Actualmente, la predicción con exactitud de la escorrentía superficial producida por fuertes precipitaciones permite conocer la vulnerabilidad de los ambientes urbanos ante futuros cambios en el clima y simular la eficacia de distintas soluciones sostenibles para reducir el peligro y el riesgo ante inundaciones urbanas. En este trabajo de investigación se presenta la construcción de un modelo hidrológico e hidráulico (1D/2D) para el análisis de inundaciones urbanas de un área de estudio en la ciudad de Cúcuta, implementando el modelo avanzado de gestión de aguas pluviales por computadora (PCSWMM) para la modelación dual del sistema de drenaje urbano existente. En la conceptualización del modelo se tuvo en cuenta la interacción entre las redes de colectores o canales del sistema (1D) y la conducción del flujo de escorrentía en la superficie (2D), mejorando la representación hidráulica de las inundaciones. Finalmente, el modelo propuesto permitió conocer las zonas propensas a inundaciones cuando se presentan precipitaciones, analizando las velocidades y profundidades del agua en las vías para diferentes periodos de retorno (10 y 50 años). Así mismo, representar la interacción entre las áreas permeables e impermeables con el sistema de drenaje urbano existente para modelar inundaciones urbanas de una forma más realista.