bluuebunny/crossref_metadata_2025 huggingface dataset:
Pemberian POC Limbah Rumah Tangga Terhadap Pertumbuhan Tanaman Kangkung Darat (Ipomoea reptans Poir.)
Authors: Ariska Nana , Aswadi Wahyu , Fajri Maulidil
Published: August 2023

Penelitian pengaruh pemberian poc limbah rumah tangga terhadap pertumbuhan tanaman kangkung darat (Ipomoea reptans poir.) dilakukan di Desa Kuta Blang, Kecamatan Samadua, Kabupaten Aceh Selatan dimulai dari bulan Agustus sampai November 2022. Rancangan yang digunakan adalah Rancangan Acak Kelompok (RAK) non faktorial yang terdiri dari 3 taraf perlakuan dengan 3 ulangan. Perlakuan yang diberikan adalah P0 (kontrol/tanpa perlakuan), P1 (30 ml POC.1-1 air), dan P2 (40 ml POC.1-1 air), sehingga diperoleh 9 unit percobaan. Hasil penelitian ini memberikan pengaruh nyata terhadap tinggi tanaman 14 HST dengan perlakuan P2 (40 ml POC.1-1 air).

Kata kunci : POC limbah rumah tangga, konsentrasi, tanaman kangkung
Vegetasi Gulma Pada Perkebunan Kelapa Sawit (Elaeis guineensis Jacq) Unit Perkebunan Bate Puteh Pt. Agro Sinergi Nusantara
Authors: Azwar Wilka , Afrillah Muhammad
Published: August 2023

Gulma merupakan tanaman pengganggu selain dari tanaman budidaya. Dalam pertumbuhan kelapa sawit, gulma akan menjadi pesaing terutama dalam memperebutkan energi cahaya, air, serta unsur hara. Tujuan dari penelitian ini adalah untuk mengetahui komposisi gulma dan hasil analisis vegetasi gulma di perkebunan Bate Puteh Afdeling I. yang di laksanakan pada bulan AgustusNovember 2022. Penelitian meliputi persiapan penelitian, survei lokasi, penentuan blok terpilih, penetuan titik sampel, pengamatan dan pengambilan sampel. Analis data yang dilakukan terdiri dari kerapatan, kerapatan relatif, frekwensi, frekwensi relative dan Summed Dominan Ratio. Hasil penelitian menunjukkan Dari hasil penelitaian yang telah dilakukan pada perkebunan kelapa sawit unit perkebunan Batee Puteh, Afdeling I PT. Agro Sinergi Nusantara di dapatkan sebanyak 541 individu, 5 Golongan jenis, dari 14 spesies. 5 Golongan Gulma berkayu, 1 teki tekian, 3 pakis pakisan, 3 Gulma berdaun sempit dan 2 golongan gulma berdaun lebar. Jumlah individu paling banyak yaitu Mucuna pruriens (182 individu) dan individu paling sedikit Phyllanthus urinaria (4 Individu). Gulma yang memiliki nilai SDR tertinggi yaitu spesies Mucuna pruriens (19,12%) dan gulma yang memiliki nilai SDR terendah Eleusine indica yaitu (2,01%). Selain Mucuna pruriens yang memiliki SDR yang tinggi spesies lain seperti Imperata cylindrica, Cyperus rotundus, Dicranopteris linearis dan Ottochloa yaitu (16.10%), (13.10%), (11.28%) dan (10.44%).

Kata kunci: Gulma, Kelapa sawit, Perkebunan, Vegetasi
Respon Tanaman Bawang Merah (Allium ascalonicum, L) Pada Pemberian Sulfur Dan Kompos Terhadap Hasil, Kadar Alliin Umbi Dan Efisiensi Pemupukan Sulfur
Authors: Juwanda Muhammad , Sakhidin Sakhidin , Kharisun Kharisun
Published: August 2023

ABSTRAK

Bawang merah merupakan komoditi tanaman sayuran yang sangat dibutuhkan oleh masyarakat Indonesia yaitu sebagai bumbu masakan. Brebes merupakan sentra bawang merah nasional namun produktivitas bawang di Brebes mengalami penurunan sebagai akibat dari rendahnya bahan organic dan ketersediaan sulfur di dalam tanah. Oleh karena itu perlu dilakukan penelitian yang dapat memberikan solusi permasalahan penurunan produktivitas bawang merah di Brebes. Penelitian ini bertujuan untuk meningkatkan hasil dan kadar alliin umbi bawang merah di Brebes. Penelitian dilakukan di polibag pada media tanah vertisol yang terletak di screen house, Desa Bulakelor, Kecamatan Ketanggungan, Kabupaten Brebes, Jawa Tengah, Indonesia pada bulan Juni – September 2019. Varietas bawang merah yang digunakan Bima Brebes. Penelitian ini merupakan percobaan faktorial yang disusun berdasarkan Rancangan Acak Kelompok Lengkap (RAKL) dengan dua faktor. Faktor pertama : dosis pupuk sulfur meliputi H0 = 0 ; H1 = 100; H2 = 200 dan H3 = 300 S kg/ha. Faktor kedua : dosis kompos daun bawang merah meliputi K0 = 0; K1 = 25; K2 = 50; dan K3 = 75 t/ha (diberikan ke tanah dengan diperkaya bakteri pengoksidasi sulfur). Terdapat 16 perlakuan, setiap perlakuan diulang tiga kali. Data hasil pengamatan dianalisis dengan uji F dan apabila ada perbedaan nyata dilanjutkan dengan uji Duncan dengan taraf kepercayaan 95 % (α = 5 %). Hasil analisis menunjukkan bahwa pengaruh dosis sulfur terhadap bobot kering tanaman per rumpun, bobot umbi kering per rumpun dan kadar alliin tergantung pada dosis kompos yang diberikan kecuali kadar air umbi, serapan S tanaman, pH dan efisiensi pemupukan S. Bobot tanaman kering, bobot umbi kering per rumpun dan kadar alliin umbi terbaik diperoleh pada pemberian dosis sulfur 100 kg/ha ditambah kompos 25 t/ha yaitu sebesar 44,42 g; 38,77 g dan 0,0730 mg/g. Pemberian dosis selanjutnya menjadi 200 – 300 kg/ha sulfur ditambah kompos 50 – 75 t/ha memberikan peningkatan hasil tidak sebaik peningkatan pemberian dosis sulfur 100 kg/ha dan kompos 25 t/ha.

Kata kunci: Vegetasi bawang merah, umbi, alliin, sulfur, kompos
Rozważania na temat tożsamości prawa kanonicznego
Authors: Coccopalmerio Francesco
Published: August 2023

Prawo kanoniczne, podobnie jak prawo w sensie ogólnym, nie łatwo jest pojmowane jako przedmiot miłości. Istotnie, często zdarza się spotykać wiernych, którzy, pomimo że posiadają bogate życie duchowe, przejawiają obojętność wobec prawa i krytykują je, bądź w skrajnych przypadkach, negują prawo uważając za wątpliwą kompatybilność norm prawnych z Ewangelią.
Międzynarodowa Konferencja Kanonistów „II Polski Synod Plenarny a synody diecezjalne”. Katowice, 8-10 września 2014 roku
Authors: Brol Patrycja
Published: August 2023

W dniach 8-10 września 2014 roku odbyła się Międzynarodowa Konferencja Naukowa Stowarzyszenia Kanonistów Polskich pt. „II Polski Synod Plenarny a synody diecezjalne” zorganizowana pod patronatem abp. dr. Wiktora Skworca, Metropolity Katowickiego. Organizatorami tego wydarzenia byli: Stowarzyszenie Kanonistów Polskich, Wydział Teologiczny Uniwersytetu Śląskiego w Katowicach, Kuria Metropolitalna Archidiecezji Katowickiej, Towarzystwo Naukowe KUL oraz Katedra Kościelnego Prawa Publicznego i Konstytucyjnego KUL.
Międzynarodowa Konferencja Naukowa „Reddite ergo quae sunt caesaris caesari et que sunt Dei Deo” z okazji 50-lecia pracy naukowej ks. prof. Józefa Krukowskiego. Lublin, 27 stycznia 2015 roku
Authors: Rogalski Paweł
Published: August 2023

Złoty jubileusz pracy naukowej ks. prof. dr. hab. Józefa Krukowskiego, 30-lecie uzyskania tytułu naukowego profesora nauk prawnych, 30-ta rocznica pracy w Papieskiej Radzie Tekstów Prawnych w Watykanie oraz 30-ta rocznica pracy w Katedrze Kościelnego Prawa Publicznego i Konstytucyjnego to motywy zorganizowania w dniu 27 stycznia 2015 r. w Katolickim Uniwersytecie Lubelskim Jana Pawła II Międzynarodowej Konferencji Naukowej pt. „Reddite ergo quae sunt Caesaris Caesari et quae sunt Dei Deo”, przygotowanej przez Wydział Prawa, Prawa Kanonicznego i Administracji KUL oraz Katedrę Kościelnego Prawa Publicznego i Konstytucyjnego KUL.
Synod diecezjalny w Kodeksie Prawa Kanonicznego z 1983 roku. Zarys problematyki
Authors: Sitarz Mirosław
Published: August 2023

The article discusses the problem of the diocesan synod in the Code of Canon Law of 1983 and the documents that were issued after the promulgation of the Code: Instruction De synodis dioecesanis agendis and Directory for the Pastoral Ministry of Bishops Apostolorum Successores. The Author begins with the definition and aims of the diocesan synod. The diocesan synod is a group of selected priests and other Christian faithful of a particular Church. The synod offers assistance to the diocesan bishop for the good of the entire diocesan community. The diocesan bishop convokes and presides over the diocesan synod. He also suspends and dissolves it. The diocesan bishop is a sole legislator at the diocesan synod. He is to communicate the texts of the synodal declarations and decrees to the metropolitan and to the conference of bishops. The diocesan bishop transmits a copy of the synodal documentation – through legate of the Roman Pontiff – to the Holy See. The Author pays attention to the fact that the diocesan synod possesses not only consultative competences but also representative and liturgical ones.
Ś.p. Ks. prof. dr hab. Marian Fąka (1924-2013)
Authors: Czujek Marcin
Published: August 2023

Za szczęście poczytuję sobie, że w moim długim życiu dużo więcej spotykałem ludzi dobrych niż złych, dużo więcej doznałem od ludzi dobrego niż złego. Szczęście dawała i wciąż mi daje przyjaźń ludzka. Pośród burz życiowych szczęście dawała mi praca naukowa i dydaktyczna, bliski kontakt z młodzieżą, z siostrami zakonnymi. Szczęście dawała mi świadomość, że w ciągu półwiecza mej pracy sądowej wielu ludziom pomogłem uporządkować zgodnie z sumieniem sprawy małżeństwa i rodziny, że mogłem przyczynić się do wyniesienia na ołtarze bł. Edmunda Bojanowskiego, bł. Siostry Sancji i bł. Matki Marii Karłowskiej. l dziś wśród tej radości spokojnie, bez cienia smutku, bez cienia melancholii, z wiarą głęboką myślę o nowej podróży, ostatniej już, o podróży, z której już nie ma powrotu – o podróży w Wieczność.
Ś.p. Ks. Prałat dr Zdzisław Majcher (1929-2012)
Authors: Bar Józef
Published: August 2023

Ks. Zdzisław Majcher urodził się 15 stycznia 1929 r. k. Jaćmierza, na Podkarpaciu. Po maturze w Sanoku, w 1948 r. wstąpił do Wyższego Seminarium Duchownego w Przemyślu. Dnia 21 czerwca 1953 r. przyjął święcenia kapłańskie z rąk Biskupa Przemyskiego Franciszka Bardy.
Ś.p. Ks. Prałat dr Marian Szczepański (1955-2014)
Authors: Kwiatkowski Damian
Published: August 2023

Urodził się 23 lutego 1955 r. w Żarkach, powiat Myszkowski. Ukończył szkołę podstawową i średnią w Żarkach. Studia filozoficzno-teologiczne podjął w 1975 r. w Wyższym Seminarium Duchowym Diecezji Częstochowskiej w Krakowie. Święcenia kapłańskie otrzymał 7 czerwca 1981 r. Zaraz po święceniach pracował jako wikariusz w parafii św. Jana Chrzciciela w Poczesnej. Był absolwentem Katolickiego Uniwersytetu Lubelskiego, gdzie studiował na Wydziale Prawa Kanonicznego.
Wymogi stanowienia prawa w Kościele partykularnym. Zarys problematyki
Authors: Sitarz Mirosław
Published: August 2023

Law-making is a formalized process. Normative act to be in force should meet the following requirements: 1) issued by a competent law-making body; 2) correctly structured; 3) announced (made available to the public) in a manner determined by the law. The Roman Pontiff, the College of Bishops, diocesan bishop, particular councils, conference of bishops and meeting of the bishops of the province are entitled to law-making in the particular Church. Congregation for Bishops in the Directory for the pastoral ministry of bishops Apostolorum Successores specified the basic criteria for the law-making bodies. The legislator in the Code of Canon Law 1983 indicated that “a law comes in to existence when it is promulgated” (can. 7). Particular laws begin to bind one month from the date of promulgation, unless another time period is determined in the law itself (can. 8 § 2). Then the Author showed the postulate. The competent law-making bodies in particular Churches and groupings of particular Churches should remember to include the date while promulgating the normative acts.
Ś.p. O. Letus Feliks Szpucha OFM (1934-2012)
Authors: Słowikowska Anna
Published: August 2023

Letus Feliks Szpucha urodził się 6 lutego 1934 r. w Teodorówce k. Biłgoraja. Do Zakonu Braci Mniejszych wstąpił w 1949 r. W seminarium duchownym w Kalwarii Zebrzydowskiej ukończył studia filozoficzno-teologiczne. W 1956 złożył profesję wieczystą, a święcenia kapłańskie przyjął w 1958 r. W latach 1958-1963 odbył studia specjalistyczne na Wydziale Prawa Kanonicznego Katolickiego Uniwersytetu Lubelskiego. Magisterium z zakresu prawa kanonicznego uzyskał w 1961 r. Rozprawę doktorską, pt. Urząd prowincjała w Zakonie Braci Mniejszych. Studium prawno-historyczne, napisaną pod kierunkiem ks. prof. dra hab. Aleksego Petraniego, obronił w 1963 r.
Sprawozdanie z Międzynarodowej Konferencji Naukowej Kanonistów Parafia w prawie kanonicznym i w prawie polskim. Gdańsk, 9-11 września 2012 r.
Authors: Maziarczuk Sylwia
Published: August 2023

W dniach 9-11 września 2012 r. w Gdańsku odbyła się Międzynarodowa Konferencja Naukowa Kanonistów nt. Parafia w prawie kanonicznym i w prawie polskim, której organizatorami byli: Stowarzyszenie Kanonistów Polskich, Kuria Metropolitalna Gdańska, Katedra Kościelnego Prawa Publicznego i Konstytucyjnego KUL oraz Wydział Nauk Prawnych Towarzystwa Naukowego KUL.
Sprawozdanie z Walnego Zebrania Stowarzyszenia Kanonistów Polskich
Authors: Lewicka Mariola
Published: August 2023

Doroczne Walne Zebranie Stowarzyszenia Kanonistów Polskich, zgodnie z postanowieniami Statutu SKP, odbyło się dnia 10 września 2012 r. w Gdańsku.
Sprawozdanie z II Ogólnopolskiej Konferencji Naukowej Kodeks Prawa Kanonicznego w badaniach młodych naukowców. Lublin, 1 czerwca 2013 r.
Authors: Zając Paweł
Published: August 2023

Dnia 1 czerwca 2013 r. w Collegium Iuridicum Katolickiego Uniwersytetu Lubelskiego Jana Pawła II odbyła się po raz drugi ogólnopolska konferencja naukowa pt. Kodeks Prawa Kanonicznego w badaniach młodych naukowców, której organizatorami byli: Katedra Kościelnego Prawa Publicznego i Konstytucyjnego KUL, Instytut Prawa Kanonicznego KUL, Wydział Prawa Kanonicznego UKSW w Warszawie, Komisja Prawnicza Oddział PAN w Lublinie, Wydział Nauk Prawnych TN KUL, Stowarzyszenie Kanonistów Polskich oraz Stowarzyszenie Absolwentów i Przyjaciół Wydziału Prawa KUL.
Rola informatyzacji w rozwoju sprawnego sądownictwa i administracji na przykładzie Krajowego Rejestru Sądowego i ksiąg wieczystych
Authors: Rojewski Michał
Published: August 2023

Autor przedstawia znaczącą rolę informatyzacji w rozwoju sprawnego sądownictwa i administracji na przykładzie Krajowego Rejestru Sądowego i ksiąg wieczystych. W Polsce to jedno z największych osiągnięć wymiaru sprawiedliwości XXI wieku. Autor wskazuje zasady prowadzenia ksiąg wieczystych: zasadę jawności formalnej ksiąg wieczystych, zasadę domniemania zgodności ze stanem prawnym, zasadę przyrzeczenia wiary publicznej oraz zasadę pierwszeństwa praw. W związku z tym autor koncentruje się na księgach wieczystych w systemie informatycznym. Rozwiązanie to umożliwia bezpośredni dostęp do ksiąg wieczystych osobom zainteresowanym wydaniem odpisów. Co więcej, dostęp do ksiąg wieczystych jest możliwy za pośrednictwem Internetu (odpowiednia strona internetowa). Przedstawiono również funkcjonowanie Krajowego Rejestru Sądowego w systemie informatycznym.
Elektroniczne postępowanie upominawcze – kilka uwag, praktyczne funkcjonowanie
Authors: Widło Jacek
Published: August 2023

Autor koncentruje się na elektronicznym postępowaniu upominawczym, które jest typem postępowania upominawczego uregulowanym w polskim systemie prawnym. Artykuł podzielony jest na cztery części. W pierwszej części opisano uwagi ogólne dotyczące elektronicznego postępowania upominawczego. Autor podaje istotne informacje na temat fakultatywnego charakteru elektronicznego postępowania upominawczego. W drugiej części autor analizuje podstawowe założenia funkcjonowania sądu elektronicznego i elektronicznego postępowania upominawczego. Reklamacja składana jest w formie elektronicznej poprzez wypełnienie on-line. Istnieje e-sąd jako wydział cywilny Sądu Okręgowego w Lublinie, który zajmuje się tymi sprawami. Powód jest zobowiązany do komunikowania się z e-sądem wyłącznie drogą elektroniczną. W trzeciej części opisano zarys funkcji systemu. System elektroniczny umożliwia potencjalnemu powodowi pozwanie kogoś do sądu. Identyfikacja powoda w Elektronicznym Postępowaniu Upominawczym następuje po założeniu indywidualnego konta. Na koniec autor przedstawia e-sąd w statystyce. Najważniejszymi zaletami elektronicznego postępowania upominawczego są: niskie koszty, elektroniczna forma wszystkich dochodzeń dokumentowych powoda czy elektroniczna egzekucja.
Sprawozdanie Zarządu Stowarzyszenia Absolwentów i Przyjaciół Wydziału Prawa KUL z działalności w roku 2010/2011
Authors: Flis Tadeusz
Published: August 2023

W roku sprawozdawczym nasze Stowarzyszenie liczyło 295 członków, w tym: 44 członków założycieli; 251 członków zwyczajnych (przybyło 34 nowych członków).
Sprawozdanie z kursu przygotowującego do egzaminów na aplikacje prawnicze. Lublin, 18 lutego - 22 kwietnia 2012 roku
Authors: Romanko Agnieszka
Published: August 2023

Celem Stowarzyszenia Absolwentów i Przyjaciół Wydziału Prawa Katolickiego Uniwersytetu Lubelskiego jest „integrowanie i promowanie absolwentów Wydziału Prawa KUL”, a także „cele edukacyjne, naukowe, informacyjne i popularyzacyjne, w szczególności rozwój i upowszechnianie nauki prawa i kultury prawniczej (…) poprzez organizowanie i prowadzenie różnego rodzaju szkoleń, wykładów, odczytów, konferencji i kursów” (Statut Stowarzyszenia, art. 3 § 1).
Niegodność dziedziczenia w polskim prawie spadkowym
Authors: Flis-Kowalska Ewelina
Published: August 2023

Autorka przedstawia podstawy prawne niegodności dziedziczenia w polskim prawie spadkowym. Autorka na wstępie wyjaśnia pojęcie „dziedziczenie” jako przejście całości praw i obowiązków majątkowych wchodzących w skład dziedziczenia na jednego lub kilku spadkobierców. Prawo polskie przewiduje dwa źródła powołania dziedziczenia: akt i testament. Autorka ukazuje podmioty, które nie dziedziczą z powodu niegodności. W kodeksie cywilnym wskazano, że niegodność dziedziczenia nie następuje z mocy prawa, lecz na mocy orzeczenia sądu. Kodeks cywilny nie precyzuje, w jakim trybie sąd orzeka o niezdolności do pracy, natomiast orzecznictwo orzecznicze Sądu Najwyższego czyni to – w procesie. Podstawy prawne do niegodności dziedziczenia wskazuje art. 928 § 1 kc. W pierwszej kolejności ustawodawca wskazuje na przestępstwo winy umyślnej wobec spadkodawcy. Autor podkreśla, że pozew może wnieść każdy, kto ma w tym interes.
TMTrans: texture mixed transformers for medical image segmentation
Authors: Chen Lifang , Wang Tao , Ge Hongze
Published: August 2023

Accurate segmentation of skin cancer is crucial for doctors to identify and treat lesions. Researchers are increasingly using auxiliary modules with Transformers to optimize the model’s ability to process global context information and reduce detail loss. Additionally, diseased skin texture differs from normal skin, and pre-processed texture images can reflect the shape and edge information of the diseased area. We propose TMTrans (Texture Mixed Transformers). We have innovatively designed a dual axis attention mechanism (IEDA-Trans) that considers both global context and local information, as well as a multi-scale fusion (MSF) module that associates surface shape information with deep semantics. Additionally, we utilize TE(Texture Enhance) and SK(Skip connection) modules to bridge the semantic gap between encoders and decoders and enhance texture features. Our model was evaluated on multiple skin datasets, including ISIC 2016/2017/2018 and PH2, and outperformed other convolution and Transformer-based models. Furthermore, we conducted a generalization test on the 2018 DSB dataset, which resulted in a nearly 2% improvement in the Dice index, demonstrating the effectiveness of our proposed model.
Two-Year Changes in Physical Activity and Concurrent Changes in Cognitive Function in a Cohort of Adults with Metabolic Syndrome
Authors: Rognoni Teresa , Fernández-Matarrubia Marta , Martinez-González Miguel Ángel , Salas-Salvadó Jordi , Corella Dolores , Castañer Olga , Martínez J. Alfredo , Alonso-Gómez Ángel M. , Gómez-Gracia Enrique , Vioque Jesús , Romaguera Dora , López-Miranda José , Estruch Ramón , Tinahones Francisco J. , Santos-Lozano José Manuel , Serra-Majem Lluis , Cano Ibañez Naomi , Tur Josep A. , Micó Pérez Rafael , Pintó Xavier , Delgado-Rodríguez Miguel , Ortiz Ramos María , Vidal Josep , Vázquez Clotilde , Daimiel Lidia , Ros Emilio , Goñi-Ruiz Nuria , Babio Nancy , Sorlí José V. , Schröder Helmut , García-Rios Antonio , Compañ-Gabucio Laura , Warnberg Julia , Zulet M. Ángeles , Chaplin Alice , Sacanella Emilio , Bouzalmate-Hajjaj Amira , Tojal-Sierra Lucas , Damas-Fuentes Miguel , Vázquez Zenaida , Gómez-Martínez Carlos , Saiz Carmen , Malcampo Mireia , Ortiz-Morales Ana M. , Martínez-Avilés Vanessa , García-Gavilan Jesús , Abete Itziar , Fitó Montserrat , Toledo Estefanía
Published: August 2023

Background:

It has been proposed that physical activity (PA) could prevent cognitive decline.

Objective:

To evaluate the association between changes in PA and changes in cognitive function in a cohort of adults with metabolic syndrome.

Methods:

Longitudinal observational study including 5,500 adults (mean age 65 years, SD = 5; women = 49.3% ) with metabolic syndrome. Participants underwent physical activity measurements and cognitive evaluation at baseline and at two-years of follow-up. PA was quantified using the Minnesota questionnaire-shortened version. Cognitive function was evaluated using a battery of tests: Mini-Mental Test Examination, Clock Drawing Test, Trail Making Test A and B, Verbal Fluency Test, and Digit Span. The primary outcome was two-year change in cognition, measured through the Global Composite Score (GCS) of all neuropsychological tests. Multivariable-adjusted linear regression models were fitted with baseline PA and their changes as the main exposures and changes in cognitive function as the outcome.

Results:

No significant association was found between PA levels (or their changes) in the GCS of cognitive function. A greater increase in PA levels was associated with a more favorable two-year change in the Trail Making Test A (Q4 versus Q1: b = – 2.24s, 95% CI –4.36 to –0.12s; p-trend = 0.020). No significant association was found for other neuropsychological test.

Conclusion:

Our results do not support an association between increases in PA and the evolution of the global cognitive function at two-year in an intervention trial which included PA promotion in one of its two randomized arms, but they suggested a possible beneficial effect of PA on attentional function in older adults.
Gut Microbiota and Cognitive Function Among Women Living with HIV
Authors: Hua Simin , Peters Brandilyn A. , Lee Susie , Fitzgerald Kathryn , Wang Zheng , Sollecito Christopher C. , Grassi Evan , Wiek Fanua , St Peter Lauren , D’Souza Gypsyamber , Weber Kathleen M. , Kaplan Robert C. , Gustafson Deborah , Sharma Anjali , Burk Robert D. , Rubin Leah H. , Qi Qibin
Published: August 2023

Background:

Altered gut microbiota has been associated with cognitive dysfunction and Alzheimer’s disease, but little is known among people living with HIV.

Objective:

To examine associations between gut microbiota and cognitive impairment among women with or without HIV.

Methods:

This is a cross-sectional study of 446 women (302 HIV+) who had completed a neuropsychological test battery and stool sample collected within 1 year. Gut microbiota composition was quantified using 16SV4 rRNA gene sequencing and microbial functional pathways were predicted using PICRUSt. Cognitive domains included attention, executive function, learning, memory, fluency, processing speed, and motor function. Cognitive impairment was defined as two or more domains with T scores < 1 SD below mean. ANCOM-II was used to identify taxa and functional pathways associated with cognitive impairment, and the associations were further examined by multivariable logistic regression.

Results:

In overall sample, adjusting for multiple covariates including HIV status, we found that higher abundance of Methanobrevibacter, Odoribacter, Pyramidobacter, Eubacterium, Ruminococcus, and Gemmiger, and lower abundance of Veillonella were associated with cognitive impairment. The associations between these taxa and cognitive impairment were more profound in HIV+ women compared to HIV- women. Most associations with bacterial taxa were observed for learning and memory. We found accompanying microbial functional differences associated with cognitive impairment, including twelve enriched pathways and three depleted pathways.

Conclusions:

In women with or without HIV infection, this study identified multiple altered gut bacterial taxa and functional pathways associated with cognitive impairment, supporting the potential role of gut microbiota in cognitive dysfunction and Alzheimer’s disease.
Preclinical Brain Network Abnormalities in Patients with Subjective Cognitive Decline
Authors: Serra Laura , Bonarota Sabrina , Di Domenico Carlotta , Caruso Giulia , Giulietti Giovanni , Caltagirone Carlo , Cercignani Mara , Bozzali Marco
Published: August 2023

Background:

Alzheimer’s disease (AD) is the most common form of dementia worldwide. Currently there are no disease modifying treatments available. Detecting subjects with increased risk to develop dementia is essential for future clinical trials. Subjective cognitive decline (SCD) is a condition defining individuals who perceive a decrease in their own cognitive functioning in the absence of any detectable deficit on neuropsychological testing. SCD individuals show AD-related biomarkers abnormalities in cerebrospinal fluid.

Objective:

The aim of the present study was to assess brain functional connectivity (FC) changes in SCD individuals.

Methods:

23 SCD and 33 healthy subjects (HS) underwent an extensive neuropsychological assessment and 3T-MRI scanning including a T1-w volume and resting-state fMRI (RS-fMRI) to assess brain atrophy and brain FC.

Results:

No between-group differences in grey matter volumes were detected. SCD subjects compared to HS showed both increased and decreased FC in the executive and parietal networks. Associations between cognitive measures, mainly assessing working memory, and FC within brain networks were found both in SCD and HS separately.

Conclusions:

SCD individuals showed FC abnormalities in networks involving fronto-parietal areas that may account for their lower visuo-spatial working memory performances. Dysfunctions in executive-frontal networks may be responsible for the cognitive decline subjectively experienced by SCD individuals despite the normal scores observed by formal neuropsychological assessment. The present study contributes to consider SCD individuals in an early AD stage with an increased risk of developing the disease in the long term.
Pathway-Specific Polygenic Risk Scores Correlate with Clinical Status and Alzheimer’s Disease-Related Biomarkers
Authors: Schork Nicholas J. , Elman Jeremy A. ,   for the Alzheimer’s Disease Neuroimaging Initiative
Published: August 2023

Background:

APOE is the largest genetic risk factor for Alzheimer’s disease (AD), but there is a substantial polygenic component. Polygenic risk scores (PRS) can summarize small effects across the genome but may obscure differential risk across molecular processes and pathways that contribute to heterogeneity of disease presentation.

Objective:

We examined polygenic risk impacting specific AD-associated pathways and its relationship with clinical status and biomarkers of amyloid, tau, and neurodegeneration (A/T/N).

Methods:

We analyzed data from 1,411 participants from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). We applied pathway analysis and clustering to identify AD-associated “pathway clusters” and construct pathway-specific PRSs (excluding the APOE region). We tested associations with diagnostic status, abnormal levels of amyloid and ptau, and hippocampal volume.

Results:

Thirteen pathway clusters were identified, and eight pathway-specific PRSs were significantly associated with AD diagnosis. Amyloid-positivity was associated with endocytosis and fibril formation, response misfolded protein, and regulation protein tyrosine PRSs. Ptau positivity and hippocampal volume were both related to protein localization and mitophagy PRS, and ptau-positivity was also associated with an immune signaling PRS. A global AD PRS showed stronger associations with diagnosis and all biomarkers compared to pathway PRSs.

Conclusions:

Pathway PRS may contribute to understanding separable disease processes, but do not add significant power for predictive purposes. These findings demonstrate that AD-phenotypes may be preferentially associated with risk in specific pathways, and defining genetic risk along multiple dimensions may clarify etiological heterogeneity in AD. This approach to delineate pathway-specific PRS can be used to study other complex diseases.
A formal model of Checked C1
Authors: Li Liyi , Liu Yiyun , Postol Deena , Lampropoulos Leonidas , Van Horn David , Hicks Michael
Published: August 2023

We present a formal model of Checked C, a dialect of C that aims to enforce spatial memory safety. Our model pays particular attention to the semantics of dynamically sized, potentially null-terminated arrays. We formalize this model in Coq, and prove that any spatial memory safety errors can be blamed on portions of the program labeled unchecked; this is a Checked C feature that supports incremental porting and backward compatibility. While our model’s operational semantics uses annotated (“fat”) pointers to enforce spatial safety, we show that such annotations can be safely erased. Using PLT Redex we formalize an executable version of our model and a compilation procedure to an untyped C-like language, as well as use randomized testing to validate that generated code faithfully simulates the original. Finally, we develop a custom random generator for well-typed and almost-well-typed terms in our Redex model, and use it to search for inconsistencies between our model and the Clang Checked C implementation. We find these steps to be a useful way to co-develop a language (Checked C is still in development) and a core model of it.
An improved PBFT consensus mechanism with trust value evaluation application in the agricultural product trusted traceability system
Authors: Sun Weiqing , Wang Shengxin , Wei Shen , Cao Pengfei , Zhao Yan , Xi Lechao , Liu Xinlu , Wang Lihua
Published: August 2023

Blockchain has the advantages of tamper proof, high reliability and traceability, so it can better support the agricultural product traceability system. However, the agricultural product supply chain has the characteristics of long chain and decentralized production, which makes the application of the combination of blockchain technology and agricultural product traceability have many nodes, large system overhead and other problems. In order to solve the above problems, this paper proposes a Practical Byzantine Fault Tolerance (PBFT) consensus mechanism based on trust value evaluation, and uses this optimization algorithm to propose an architecture model to meet the demand for trusted traceability of agricultural product supply chain, so as to realize the distributed storage and security protection of supply chain data. In order to ensure the effective operation of the blockchain system, this paper studies the consensus mechanism in the blockchain network, designs a trust value evaluation model to calculate the trust value of nodes, and selects trusted nodes to join the consensus group based on the trust value, which ensures the credibility of the consensus nodes. At the same time, the consistency protocol is optimized to reduce the communication overhead in the consensus process. The experimental results show that the consensus mechanism improved in this paper has certain advantages in communication overhead, transaction delay and throughput. Compared with the existing storage model, the model described in this paper has higher security and throughput efficiency, effectively ensures the reliable traceability of data, and can be better applied to the traceability scenario of agricultural product supply chain.
SAFETY OF REGIONAL ANESTHESIA IN UKRAINE SURVEY: ARE HOSPITALS READY FOR THE LOCAL ANESTHETIC SYSTEMIC TOXICITY (LAST)?
Authors: Semenko Nataliia , Frank Michael , Kuchyn Iurii , Bielka Kateryna , Spitsyn Vitalii , Parii Vasyl , Lykhodii Viktor
Published: August 2023

Background. A survey was conducted among anesthesiologists in 38 Ukrainian hospitals to evaluate the current incidence and treatment quality of the local anesthetic systemic toxicity (LAST). With the growing preference for regional anesthetic techniques, implementation of measures for timely detection and treatment of LAST is becoming a priority for many surgical hospitals. This study aims to provide primary country-wide epidemiological data to guide further safety improvement in Ukraine.

It should be noted, that the survey was performed before the beginning of the full-scale Russian invasion of Ukraine. The resulting surge in the incidence of limb injury has resulted in an unprecedented scale of application of regional anesthesia, including out-of-hospital cases with very limited monitoring, which will no doubt generate great amount of new data on the subject. We hope that our current analysis may be used as a reference point for the future research on this subject.

Material and methods.  A link to the survey was distributed via e-mail to the members of the Association of Anesthesiologists of Ukraine. Data submission was anonymous. Statistical analysis was performed using Microsoft Excel. Descriptive statistics are provided.

Results. Responses were submitted by 186 anesthesiologists from 38 Ukrainian cities. Among them, 65.9% practice in public hospitals, 25.4% - in private hospitals, 8.7% - in university hospitals. Majority of respondents (60.3%) reported performing over 100 regional anesthetic procedures per year. Peripheral nerve blocks were routinely performed in the hospitals of 76.9% of respondents. 42.4% are using peripheral nerve blocks or more times per week, 24.4% perform this amount monthly, 21.7% - yearly, with 11.5% not utilizing peripheral nerve blocks at all.

Ultrasound guidance was commonly used by 64.1% of anesthesiologists, 60.3% reported relying on landmark techniques often and 38.5% are routinely using a neuromuscular electrical stimulator.

LAST cases were previously encountered by 37.2% of respondents. However, only 37% have reported having a LAST protocol in their hospital and 42.3% did not have a lipid emulsion available. Regarding patient education, in 62.8% of cases the patients were specifically warned about the possible complications of regional anesthesia prior to procedures, where it was performed. When the local anesthetic related adverse events did occur, they were recorded in the patient’s card in 27.2% of cases; the chief of anesthesiology department was informed in 36.9%, while in 35.9% the event was not reported in any way.

Conclusions. The practice of regional anesthesia is becoming more widespread in Ukraine, but the minimal measures required to provide patient safety during such procedures are still not being employed in many hospitals.
MATHEMATICAL MODEL FOR PREDICTING THE SEVERITY OF THE COURSE OF ACUTE PANCREATITIS
Authors: Kolosovych I.V. , Bystrytska M.A. , Hanol I.V.
Published: August 2023

Background. A feature of acute pancreatitis is the high risk of developing complications (occurring in 50% of patients), the mortality rate of which reaches 15%, and with a severe course varies within 40-70%. It has been proven that timely determination of the severity of the disease, selection of appropriate treatment tactics, early diagnosis of complications and their prevention significantly improve treatment results.

Aim: to develop a modern mathematical model for predicting the severity of the course of acute pancreatitis, taking into account indicators of calcium-phosphorus metabolism, hemocoagulation factors and serological examination data for Helicobacter pylori.

Materials and methods. The study was based on the results of an examination of 280 patients with acute pancreatitis, who were divided into two groups: the main group (n=187) – patients with a severe course and a comparison group (n=93) – patients with a mild and moderate course of the disease. To develop a mathematical model, the following indicators were analyzed and compared: duration of the disease before hospitalization, body mass index, number of leukocytes, C-reactive protein, blood glucose, procalcitonin, interleukin-6, immunoglobulin M to Helicobacter pylori, thrombin-antithrombin III complex, activity of tissue plasminogen activator, serum calcium, albumin corrected calcium, vitamin D.

Results. Based on the obtained results, we developed a mathematical model for predicting the severity of the course of acute pancreatitis and revealed a correlation between the calculated scores (according to the mathematical model) and the APACHE II scale (severe course of 8 points and more). The step-by-step creation of a model by the method of multiple regression analysis with a gradual decrease in the number of indicators from 12 to 8 and to 6 allowed us to propose a mathematical model that has high accuracy for predicting the severe course of acute pancreatitis (R=0.82; R2=0.66; p< 0.0001). The obtained data demonstrate the dependence of the "severe course" factor on the content of vitamin D, immunoglobulin M to Helicobacter pylori and the activity of tissue plasminogen activator and substantiate the need for their early determination in patients with acute pancreatitis. Therefore, the developed mathematical model is highly informative and can be used in medical practice for early prediction of the severe course of acute pancreatitis.

Conclusions. The dependence of the «severe course» factor in patients with acute pancreatitis on the content of vitamin D, immunoglobulin M to Helicobacter pylori and the activity of tissue plasminogen activator has been proven, and the need for their determination in the early period of the disease is substantiated. Using the method of multiple regression analysis, a mathematical model was developed that has high accuracy for predicting the severe course of acute pancreatitis (R=0.82; R2=0.66; p<0.0001).
METHODOLOGY FOR ASSESSMENT OF THE QUALITY OF LIFE OF CHILDREN WITH CORONA VIRUS INFECTION AND THE POST-VIDAL SYNDROME
Authors: Marushko Yu.V. , Shipelik T.V. , Hyschak T.V. , Kramarev S.O. , Kryuchko T.O. , Pisarev A.O. , Kryvopustov S.P.
Published: August 2023

Background. The urgency of the problem is due to the rapid spread of the coronavirus infection in the world, as well as the frequent occurrence of a wide range of post-coronavirus complications in children, which significantly affect the quality of life. These changes also remain in the post-Covid period. Assessment of the quality of life in children with post-covid syndrome in Ukraine is at the stage of formation, therefore, methodologically, the creation and validation of children's questionnaires with subsequent assessment of the quality of life remains an urgent problem.

Aim: to summarize data from the literature regarding the study of health-related quality of life in children with SARS-CoV-2 infection and post-covid syndrome.

Materials and methods. An assessment of literature data on the frequency and course of coronavirus infection, its manifestations, damage to the respiratory system and other organs and systems in children, and asthenic manifestations was carried out.

Results. Based on the analysis of the scientific literature, the possibilities of using the quality of life assessment method in pediatric practice, in particular in children with COVID-19 and the consequences of the infection, were considered. One of the most frequently used questionnaires for assessing the quality of life in children is the PedsQL 4.0 questionnaire, which, due to good psychometric qualities, the availability of parallel forms for children and parents, a wide age range, simplicity and ease of filling out, can be recommended for determining the health-related quality of life in children. It is shown how the study of the quality of life related to health allows to study the impact of the disease and treatment on the components of the child's health.

Conclusions. Research on quality of life allows monitoring the condition of a child with post-covid syndrome during treatment and rehabilitation, as well as evaluating the effectiveness of these measures.
THERAPEUTIC POTENTIAL OF CANNABIDIOL: THE MOST IMPORTANT ACHIEVEMENTS ON THE WAY TO A NEW ERA
Authors: Shevchuk M.M. , Volos L.I.
Published: August 2023

Background. Cannabidiol (CBD), found in Cannabis sativa (hemp), is a non-psychoactive phytochemical substance that has gained considerable popularity over the past decade. Cannabidiol is the main phytocannabinoid, its share in the plant extract can reach 40%. Cannabidiol does not have any of the psychoactive properties that tetrahydrocannabinol (THC) and has a significant advantage for clinical use. Studies of cannabidiol involve studies of cognitive, anxiety and movement disorders, and chronic pain, but there is a lack of high-quality evidence that cannabidiol is effective for these conditions, such as safety and precise dose ranges for each disorder.

Aim: to analyze the main achievements in the development of experimental and clinical use of cannabidiol.

Materials and methods. We conducted a search for scientific studies related to the therapeutic use of cannabidiol. The included studies were selected based on a search of the online databases PubMed, Web of Science, Scopus, Google Scholar for documents related to the history of research and use of cannabidiol (cannabis, cannabidiol, tetrahydrocannabinol, endocannabinoid system, cannabinoid receptors were used as keywords). The search was carried out by two independent authors and 158 sources were selected for analysis, of which 61 were used that met the search criteria.

Results. Based on the analysis of experimental and clinical studies, it was established that cannabidiol has various properties, including antiapoptotic, antioxidant, anti-inflammatory, antipsychotic and neuroprotective. In addition, basic and clinical studies of the effects of cannabidiol have been conducted in the context of many other health conditions, including its potential use in epilepsy, depression, neurodystrophic diseases, schizophrenia, and social phobia.

Conclusion. Therefore, cannabidiol is a non-psychoactive phytochemical compound that can help patients with a different clinical condition. Despite the achievements, further studies are needed to determine the administration regimen and dose, likely side effects with long-term use, particularly in clinical settings.
Using Genetic Algorithms to Segment Images: A Review
Authors: Gdeeb Rasha Talib
Published: August 2023

The genetic algorithm plays a pivotal role in image processing, particularly in the critical stage of image segmentation. The process of segmenting photographs is an essential method in the field. Identifying objects, extracting features for object recognition, and classifying are integral components of image processing. However, the effectiveness of these activities relies on the quality of the operations performed. The work at hand in the domain of image processing is notably arduous and intricate. The segmentation of photos cannot be consistently achieved through the utilization of a singular approach. Nevertheless, it is not possible to consistently classify photos into extensive categories. The complexity inherent in the image segmentation task necessitates careful consideration when determining a suitable set of parameters to employ. The arduous task of selecting picture parameters the picture segmentation problem encompasses various factors that contribute to the complexity of the selection process. An optimization problem is employed to efficiently locate the global maximum inside a given search space, with the problem being formulated as a Genetic Algorithm. Subsequently, the task of determining the most suitable segmentation criteria for an image is successfully overcome. The primary objective of this study was to investigate the viability of employing genetic algorithms within the domain of image segmentation.
Prevalence of Class I, II and III Integrons in Uropathogenic Escherichia Coli Strains Isolated from Patients with Urinary Tract Infection in Shiraz, Iran
Authors:   Department of Microbiology, Faculty of Basic Sciences, Shiraz Branch, Islamic Azad University, Shiraz, Iran, Shariat Afsoon , Fathpoor Fatemeh ,   Department of Microbiology, Shiraz Branch, Islamic Azad University, Shiraz, Iran
Published: August 2023

Background and Objectives Transfer of antibiotic resistance genes by integrons is the main cause of drug-resistant bacteria. This study aims to evaluate the prevalence of class I, II, and III integrons among uropathogenic Escherichia Coli (UPEC) strains isolated from patients with Urinary tract infection (UTI). Subjects and Methods This cross-sectional study was carried out on 50 UPEC strains isolated from patients with UTI referred to hospitals in Shiraz, Iran in 2020. Antibiotic susceptibility pattern was evaluated by the disk diffusion susceptibility test. Then, the prevalence of class 1 to 3 integrons in the isolates was investigated by the polymerase chain reaction test. Data were statistically analyzed in SPSS software using chi-square test. P≤0.05 was statistically significant. Results 42% of isolates had multi-drug resistance. The highest antibiotic resistance and sensitivity were related to trimethoprim/sulfamethoxazole (52%) and gentamicin (90%), respectively. There was a significant relationship between the presence of class I integron and resistance to amikacin and ciprofloxacin, between the presence of class II integron and resistance to gentamicin, and between the presence of class III integron and resistance to trimethoprim/sulfamethoxazole and nalidixic acid (P<0.05). Conclusion There is a significant association between the presence of class I, II and III integrons and antibiotic resistance in UPEC strains isolated from patients with UTI. Infection control measures and suitable treatment methods are needed for preventing the spread of these isolates in the hospitals and health centers in Shiraz city.
Motor Strategies Used to Restore Balance in People With and Without Impaired Sensory Organization Suffering From Diabetic Polyneuropathy
Authors:   Musculoskeletal Rehabilitation Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran, Kosarian Zahra , Zakerkish Mehrnoosh ,   Diabetes Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran, Mehravar Mohammad ,   Department of Physiotherapy, School of Rehabilitation Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran, Shaterzadeh Yazdi MohammadJafar ,   Department of Physiotherapy, School of Rehabilitation Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran, Hesam Saeed ,   Department of Biostatistics and Epidemiology, School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Published: August 2023

Background and Objectives Reduced ability to control balance is one of the disorders affecting the quality of life and daily activities of people with diabetic polyneuropathy (DPN), which can lead to dangerous consequences such as falling. By identifying the causes of balance disorders, we can better understand this condition to provide effective and evidence-based treatments for these patients. This study aims to investigate and compare the use of motor strategies in people with and without impaired sensory organization suffering from DPN. Subjects and Methods In this cross-sectional study, 40 people with DPN participated. Their demographic information were recorded and then underwent balance performance test using the sensory organization test. Based on the results, they were divided into two groups: Control group without impaired sensory organization (n=18) and Patient group with impaired sensory organization (n=22). Results The prevalence of inappropriate use of motor strategies to restore balance in DPN patients with impaired sensory organization was higher than in the control group. The adopted inappropriate strategy was mostly in using ankle strategy, where the somatosensory and visual perturbations were higher. Conclusion Patients with DPN use ankle strategy, instead of hip strategy, to restore balance. This non-use of hip strategy is more common in patients with impaired sensory organization.