bluuebunny/crossref_metadata_2025 huggingface dataset:
JWST detection of heavy neutron capture elements in a compact object merger
Authors: Levan Andrew , Gompertz Benjamin , Salafia Om Sharan , Bulla Mattia , Burns Eric , Hotokezaka Kenta , Izzo Luca , Lamb Gavin , Malesani Daniele , Oates Samantha , Ravasio Maria , Escorial Alicia Rouco , Schneider Benjamin , Sarin Nikhil , Schulze Steve , Tanvir Nial , Ackley Kendall , Anderson Gemma , Brammer Gabriel , Christensen Lise , Dhillon Vikram , Evans Phil , Fausnaugh Michael , Fong Wen-fai , Fruchter Andrew , Fryer Chris , Fynbo Johan , Gaspari Nicola , Heintz Kasper , Hjorth Jens , Kennea Jamie , Kennedy Mark , Laskar Tanmoy , Leloudas Giorgos , Mandel Ilya , Martín-Carrillo Antonio , Metzger Brian , Nicholl Matt , Nugent Anya , Palmerio Jesse , Pugilese Giovanna , Rastinejad Jillian , Rhodes Lauren , Rossi Andrea , Smartt Stephen , Stevance Heloise , Tohuvavohu Aaron , Horst Alexander van der , Vergani Susanna , Watson Darach , Barclay Thomas , Bhirombhakdi Kornpob , Breedt Elme , Breeveld Alice , Brown Alex , Campana Sergio , D'Avanzo Paolo , D'Elia Valerio , De Pasquale Massimiliano , Dyer Martin , Galloway Duncan , Garbutt James , Green Matthew , Hartmann Dieter , Jakobsson Pall , Kerry Paul , Langeroodi Danial , Leung James , Littlefair Stuart , Munday James , O'Brien Paul , Parsons Steven , Pelisoli Ingrid , Sahman Dave , Salvaterra Ruben , Tagliaferri Gianpiero , Thöne Christina , Postigo Antonio de Ugarte , Sbarufatti Boris , Chrimes Ashley , Steeghs Danny , Kann David
Published: July 2023

The mergers of binary compact objects such as neutron stars and black holes are of central interest to several areas of astrophysics, including as the progenitors of gamma-ray bursts (GRBs), sources of high-frequency gravitational waves and likely production sites for heavy element nucleosynthesis via rapid neutron capture (the r-process). These heavy elements include some of great geophysical, biological and cultural importance, such as thorium, iodine, and gold. Here we present observations of the exceptionally bright gamma-ray burst GRB230307A. We show that GRB 230307A belongs to the class of long-duration gamma-ray bursts associated with compact object mergers, and contains a kilonova similar to AT2017gfo, associated with the gravitational-wave merger GW170817. We obtained James Webb Space Telescope mid-infrared (mid-IR) imaging and spectroscopy 29 & 61 days after the burst. The spectroscopy shows an emission line at 2.1 microns which we interpret as tellurium (atomic mass A=130), and a very red source, emitting most of its light in the mid-IR due to the production of lanthanides. These observations demonstrate that nucleosynthesis in GRBs can create r-process elements across a broad atomic mass range and play a central role in heavy element nucleosynthesis across the Universe.
Cancer cells transfer invasive properties through collagen-tracks
Authors: Saltel Frederic , Normand Léa , Rouyer Lucile , Richard Elodie , Allain Nathalie , Di-Tommaso Sylvaine , Dourthe Cyril , Anne-Aurélie Raymond , Dupuy Jean-Wiliam , Moreau Violaine , McGrogan Gaetan , Dugot-Senant Nathalie , Bouter Anthony , Tan Sisareuth , Favereaux Alexandre , Ros Manon
Published: July 2023

Invasion and migration through the extracellular matrix are prerequisites for metastasis, the leading cause of cancer-related deaths. During tumor development, the extracellular matrix is remodeled, including by overexpressing type I collagen that facilitate cancer dissemination. Most studies have focused on events at the leading edge as cells invade. We describe a new event at the trailing edge, as cells detach from the matrix.
We show that small vesicles containing the collagen receptor DDR1 are left behind on collagen fibrils in the migration path. We named these structures attached to the collagen fibers "collagen-tracks". The vesicles are similar in size to exosomes but lack the exosome markers, and they also are different to migrasomes. We show that collagen-track formation is stimulated by DDR1 and by factors that promote adhesion, including collagen cross-linking. We report the protein, mRNA and miRNA content of collagen-tracks. They contain adhesion proteins, suggesting that they form when membrane fragments containing adhesions are torn from the cell as it migrates along collagen fibrils. We show that collagen-tracks are deposited by breast cancer cells in 3D matrices in vitro and in vivo. Collagen-tracks are stable and can be taken up by surrounding cells, promoting epithelial to mesenchymal transition, matrix degradation and invasion, finally leading to increased lung metastasis of breast cancer cells.
In summary, we have identified and characterized a new vesicle entity directly attached to collagen fibrils that plays a role in cell-cell communication and can transfer invasive properties to surrounding cells. We conclude that cancer-related collagen-tracks are a new player acting locally to drive tumor invasion and metastasis
Preterm birth associated factors. A case-control study.
Authors: Almaghaslah Eman , Saif Ahmed Al , Algadeeb Kumail , Albannay Zainab , AlThani Jassem , Al-Saleh Wardah , Alrashed Malak , AlSaleh Hanin
Published: July 2023

Background: Preterm births are an increasing trend globally, and it demands healthcare and social support. Thus, studying the sociodemographic risk factors associated with preterm birth reflects a better understanding and enables the development of efficient, cost-effective maternal health services.
Objective: To assess the association between pregnancy planning and preterm birth. Then, our secondary objective is to investigate the sociodemographic factors among preterm and full-term delivered women.
Methods: A case‒control study was conducted on n=391 postpartum women. Fifty-two preterm births (cases) and 339 full-term births (controls) were performed in a referring hospital in Hofuf, Saudi Arabia. A survey is collected from postpartum women rating pregnancy planning practices and other sociodemographic characteristics.
Results: The majority, 85% of the sample, were housewives, and 80% were within a low-income category earning less than 10,000 SR per month for both preterm and full-term mothers. We found a greater odds of having chronic illness during pregnancy (OR= 1.76, 95% CI (1.062, 2.917)) the preterm birth mothers.
Conclusion and recommendation: Our study highlighted the preterm associated risk factors namely, presence of pregnancy illness, more likely to end by cesarian section, and to have a neonatal complication. Thus, the result highlighted the need for careful antenatal care pregnancy management for women with chronic illness such as diabetes, and hypertension. Therefore, we also recommend pregnancy preparation and planning for healthy pregnancy specially for high-risk pregnancy.
The arbitrary value of time as a key quality indicator for EMS care: An observational study using the SPART model on the relationship between time and clinical reasoning activities by EMS providers.
Authors: Dercksen Bert , Struys Michel.M.R.F. , Paans Wolter , Cnossen Fokie
Published: July 2023

Background
Time is a key quality indicator for EMS care, and many efforts are directed at minimizing the time used for response, on-site and transport periods. In some deployments, this is undoubtedly justified, but in many medical situations, time might be overestimated as a quality indicator. To assess the value of time as a quality indicator, we conceived a study to investigate the relationship between EMS clinical reasoning processes and the variable time.
Methods
Using video recordings of EMS deployments, we qualitatively identified professional activities, determined their time of execution within a deployment and measured the duration of these activities. The observed activities were classified using the SPART model, which identifies ten categories in the EMS care process. We assigned each diagnostic and treatment activity to a category. The measured time variables were interpreted both qualitatively and by using descriptive statistics.
Results
We identified 1683 activities (total duration 12h34m30s, 28 clinical cases, 20 participants). Diagnostic activities took 4.3 times more time than therapy. The diagnostic process sometimes continued after the clinical decision had been made, but this did not alter the decision taken.
Conclusion
Our observations showed that most of the time was spent on the diagnostic process leading to a clinical decision. Sometimes, this process was terminated too early, and the clinical decision seemed to be taken too soon. This phenomenon is known as premature closure (a hypothesis is considered final before all evidence is searched for and evaluated), possibly negatively affecting the quality of care. We speculate that this cognitive bias could be minimized if the deployment duration is considered less critical, an issue we feel warrants further research.
PhCYP724B1 positively regulates shoot branching
Authors: Dong Lili , Xu Xiaorong , Jiang Ziying , Yao Huanyu , Tian Wang , Deng Xinyi
Published: July 2023

Background: Petunia hybrida is an important ornamental plant, and branch regulation is of great significance in its cultivation.
Results: We isolated the homologous gene of CYP724B1 from Petunia × hybrida cv 'Mitchell Diploid', and named PhCYP724B1. Expression analysis revealed that PhCYP724B1 was expressed highest in buds, while lowest in flowers. The expression level of PhCYP724B1 was higher in the petunia variety with more branches, while lower in variety with fewer branches. Subcellular localization assays demonstrated that PhCYP724B1 protein was localized on the endoplasmic reticulum. Furthermore, overexpression of PhCYP724B1 in transgenic Arabidopsis and petunia plants both enhanced shoot branching. In contrast, RNAi of PhCYP724B1 in petunia resulted in a significantly inhibited shoot branching phenotype.
Conclusions: Taken together, the results denote new insights into the important role of PhCYP724B1 in regulating petunia shoot branching.
Response surface methodology for modeling of the critical electric field of a single drop subjected to different electric waveforms
Authors: Shahmoradi Zahra , Mousavi Seyed Hamed
Published: July 2023

Electro-coalescence has been an environmentally friendly technology for decades. However, electric field strength should not exceed a critical value (Ecrit) to inhibit droplets from disintegrating during coalescence. In this study, response surface methodology (RSM) with a D-optimal design was utilized to develop a model to achieve the maximum Ecrit of a single drop. Waveform, frequency, drop diameter and interfacial tension were statistically significant. Frequency change revealed Ecrit increases with a moderate slope for all waveforms. This was attributed to less degree of drop deformation due to shorter on-time intervals of pulsatile electric field and non-compliance of drop vibration with field frequency. Following the revelation of interaction between diameter and frequency, it was observed elevated frequencies have a significant impact on larger droplets, and the sensitivity of Ecrit to the diameter decreases with frequency. This suggests higher frequencies as a useful and fast controllable variable to compensate for the effect of droplet size distribution. Optimization suggested a minimum drop diameter and a maximum frequency that can be used as two important limits for the robust design of electro-coalescers. The best and worst results in all cases corresponded to Pulse 90 and 10 waveforms respectively.
Developmental molecular controls over arealization of descending cortical motor pathways
Authors: Jabaudon Denis , Abe Philipp , Lavalley Adrien , Morassut Ilaria , Klingler Esther , Santinha Antonio , Platt Randall
Published: July 2023

Layer 5 extratelencephalic (ET) neurons are a main class of neocortical projection neurons that predominate in the motor cortex and send their axon to the pons and spinal cord, and collaterals to the thalamus and multiple deep subcerebral structures. Precise connectivity of ET neurons is critical for fine motor control; they are central to loss of function upon spinal cord injury and specifically degenerate in select neurodegenerative disorders. ET neurons consist of several types of cells with distinct laminar and areal locations, molecular identities, connectivities, and functions. Within layer 5 of the cortex, two cardinal subtypes of ET neurons have been identified: “ET lower” neurons, which express Slco2a1 and project to distal targets including the spinal cord, and “ET upper“ neurons, which express Nprs1 or Hpgd and project more proximally to the pons and thalamus. Despite their critical function, how these neuronal subtypes emerge during development and acquire their area-specific distributions remains unaddressed. Here, using combinations of anatomical labeling, MAPseq mapping, and single-nucleus transcriptomics across developing cortical areas, we reveal that these two subtypes of ET neurons are present at birth along opposite antero-posterior cortical gradients. We first characterize area-specific developmental axonal dynamics of ET lower and ET upper neurons and find that the latter can emerge by pruning of subsets of ET lower neurons. We next identify area- and ET neuron type-specific developmental transcriptional programs to identify key target genes in vivo. Finally, we reprogram ET neuron area-specific connectivity from motor to visual by postnatal in vivo combinatorial knockout of three key type-specific transcription factors. Together, these findings delineate the functional transcriptional programs controlling ET neuron diversity across cortical areas and provide a molecular blueprint to investigate and direct the developmental emergence of corticospinal motor control.
Single cell immunoprofile of synovial fluid in rheumatoid arthritis with TNF-α/JAK inhibitor treatment
Authors: Xu Heng , Xia Xuyang , He Chenjia , Xue Zhinan , Wang Yuelan , Ren Zhixiang , Huang Yupeng , Luo Han , Chen Hai-Ning , Zhang Weihan , Huang Li-Bin , Shi Yunying , Bai Yangjuan , Cai Pei , Wang Lanlan , Zhang Feng , Qian Maoxiang , Zhang Wei , Shu Yang , Yin Geng , Xie Qibing
Published: July 2023

Increased volume of synovial fluid (SF) with large amounts of immune cells is present in the joint cavity of many patients with rheumatoid arthritis (RA), syndrome of which can be controlled by TNF-α/JAK inhibitors. Here, we applied single-cell RNA sequencing (scRNA-seq) and subsequent validations to profile the cell components, and their crosstalk in SF from RA patients pre-/post-treated with adalimumab/tofacitinib. Although the proportion of pathogenic cells (e.g., SPP1+ macrophage and CXCL13+CD4+ T cell) were not decreased after treatment, several genes (e.g., SPP1 and STAT1), molecular pathways (e.g., JAK/STAT) and cell-cell communications were altered in drug-specific manner. Particularly, SPP1+ macrophage can increase the inflammatory response of fibroblast-like synoviocytes in vitro and exhibit the most prolific communications with CXCL13+CD4+ T cell, which are abolished after treatment and positively related to treatment efficacy. Our study establishes the correlation of the pathogenic SF cells with progression and treatment outcomes in RA.
Impacts of Pharmacists-Managed Outpatient Clinic in patients with Hepatitis C virus infection: A Retrospective Study in China
Authors: Huang Can , Gao Aiping , Guo Cuixia , Jia Jinmei , Zheng Yonghong , liu wei
Published: July 2023

Objective
Pharmacists are health care professionals who are actively involved in identifying and solving drug-related problems (DRPs) in patients with hepatitis C virus (HCV) infection. However, the effectiveness of pharmaceutical services at outpatient clinic for patients with HCV infection have not been reported in China. This study aims to describe and investigate the impacts of pharmacists-managed outpatient clinic in patients with HCV infection.
Methods
We conducted a descriptive and retrospective study between May 2020 and April 2022. In order to give full play to the efficacy of direct-acting antivirals (DAAs), we established a referral process for HCV patients with DAAs. Doctors prescribed DAAs for HCV-infected outpatients, and then transferred them to the outpatient clinic managed by pharmacists. Pharmacists cooperated to complete the pharmaceutical monitoring of DAAs treatment for patients. The pharmacist conducted a comprehensive evaluation of the patient's medication and developed planned intervention measures based on identified DRPs.
Results
A total of 473 eligible patients participated in 851 pharmaceutical care. A total of 518 DRPs were identified (an average of 1.1 per patient). Treatment effectiveness (48.8%) was the most common DRP. The most commonly recommended intervention was changing the drug (18.3%). There were 97.1% patients accepting the interventions and 93.05% patients completely implemented. The overall sustained virologic response at week 12 posttreatment (SVR12) rate was 98.5% (466/473). The most cost-effective treatment was selected in 98.7% of patients.
Conclusions
We confirmed that pharmacists had a valuable role to perform pharmacy services for HCV-infected outpatients. The intervention of pharmacists is effective in solving the DRPs and saving drug costs.
Influence of various hosts on the life cycle, morphometrics, feeding and ovipositional preference for invasive fall armyworm, Spodoptera frugiperda (J.E. Smith)
Authors: K Jatin , SPS Tomar , Kukanur Vinod , Kota Sathish , N Ramana , Mishra Suraj , Jaba Jagdish
Published: July 2023

Influence of diverse natural hosts (major cereals, legumes, Bt cotton, oil seed crops and artificial diet) on the biology, morphometrics, and ovipositional preference of invasive fall armyworm were investigated under laboratory conditions. The results revealed that FAW could complete its life cycle on all the host crops except Bt-cotton. Among the various hosts, Maize was the best suitable host for FAW. It supported FAW for faster development, most robust larvae and pupae, and adults. Among the hosts studied Cotton and Cowpea were least preferred and had adverse effects on FAW growth and development. The order of host preference from most preferred to least preferred host being maize followed sorghum, castor, artificial diet, sunflower, soybean, rice, pearl millet, cotton and cowpea. Our findings can help to redefine the protocols for quicker multiplication of FAW, implement newer Integrated pest management (IPM) programs, develop new forecasting models and to develop new cultural management practices.
Heterogeneous Warming Rates and Decline in Snow Persistence across Mountains Worldwide
Authors: Ha Kyung-Ja , Blau Manuel Tobias , Kad Pratik , Turton Jenny V.
Published: July 2023

The warming of mountainous regions has become evident in recent years with a global average warming rate of 1.41 °C from 1979 to 2022. Our study aims to understand observed changes in snow persistence across mountain regions worldwide, using reanalysis and satellite data. By taking a global perspective, we bridge the gap between regional findings and provide a comprehensive understanding of the impact of increases in global warming on mountain snow decline. Here, we demonstrate that the mountain snow persistence is significantly declining over the past 44 years, with a global mean decline of 7.67 %. The trends in regional snow cover persistence exhibit a heterogeneous and non-linear response to its regional warming rate. A decomposition of snow depth reveals the snowfall ratio majorly contributes to high latitudes, and the snowfall accumulation ratio plays a large role where the melting trend exceeds the snowfall trend. The recent Coupled Model Intercomparison Project 6 (CMIP6) has shown limitations in accurately capturing the mountain snow persistence. Our study provides valuable insights into the intricate interplay between global warming and declining snow cover persistence. Our findings attribute the observed reduction in snow persistence and shed light on decreased snowfall with increased snow melting contributions. Disclosure of the impact of this changing mountain snow is critical for informing sustainable development and preparing for the potential consequences of these changes.
CuCrZr alloy manufactured by LPBF process: correlation between microstructure, mechanical and thermal properties
Authors: Biffi Carlo Alberto , Fiocchi Jacopo , Boldrini Stefano , Tuissi Ausonio
Published: July 2023

Copper based alloys are promising materials for electrical and thermal devices. In this respect, the use of laser powder bed fusion (LPBF) allows the realization of 3D complex structures, possibly enhancing the functional performances of such devices. LPBF also induces refined microstructures and build-up of residual stresses, due to the rapid solidifications and high cooling rate. In this work a CuCrZr alloy was manufactured by LPBF and a process feasibility window was defined. The effect of a heat treatment, consisting of solution annealing and artificial aging, and of the building direction on the microstructure, tensile, and thermal properties was evaluated. It was found that thermal conductivity is improved by the heat treatment and that thermal conductivity resulted anisotropic, being higher in the growth direction.
Molecular mechanisms in metal oxide nanoparticle Tryptophan interactions
Authors: Kessler Vadim , Nefedova Alexandra , Svensson Fredric , Vanetsev Alexander , Agback Peter , Agback Tatiana , Kloo Lars , Tätte Tanel , Ivask Angela , Seisenbaeva Gulaim
Published: July 2023

One of the crucial metabolic processes for both plant and animal kingdoms is oxidation of amino acid tryptophan (TRP) that regulates the plant growth and controls hunger and sleeping patterns in animals. Here, we report revolutionary insights into how this process can be crucially effected by interactions with metal oxide nanoparticles (NP), creating a toolbox for a plethora of important biomedical and agricultural applications. Molecular mechanisms in TRP-NP interactions were revealed by NMR and optical spectroscopy for ceria and titania, and by X-ray single crystal and a computational study of a model TRP-polyoxometalate complexes. Nanozyme activity, involving concerted proton and electron transfer to the NP surface for oxides with high oxidative potential, CeO2 or WO3, converted TRP into a tricyclic organic acid resembling natural plant hormones, auxins. TiO2, a much poorer oxidant, was strongly binding TRP without concurrent oxidation in the dark, but oxidized it non-specifically via release of reactive oxygen species (ROS) in daylight.
The Potential Role of Ocular and Otolaryngological Mucus Proteins in Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome
Authors: Huitsing Kaylin , Tritsch Tara , Arias Francisco J. Carrera , Collado Fanny , Aenlle Kristina , Nathason Lubov , Fletcher Mary Ann , Klimas Nancy G. , Craddock Travis
Published: July 2023

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating illness associated with a constellation of other symptoms. While the most common symptom is unrelenting fatigue, many individuals also report suffering from rhinitis, dry eyes and a sore throat. Mucin proteins are responsible for contributing to the formation of mucosal membranes throughout the body. These mucosal pathways contribute to the body’s defense mechanisms involving pathogenic onset. When compromised by pathogens the epithelium releases numerous cytokines and enters a prolonged state of inflammation to eradicate any particular infection. Based on genetic analysis, and computational theory and modeling we hypothesize that mucin protein dysfunction may contribute to ME/CFS symptoms due to the inability to form adequate mucosal layers throughout the body, especially in the ocular and otolaryngological pathways leading to low grade chronic inflammation and the exacerbation of symptoms.
Mechanical and Acoustic Properties of Sandstone under Freeze-Thaw and Cyclic Loading Alternations
Authors: Yuan Yeqing
Published: July 2023

This research investigates the mechanical and acoustic properties of sandstone under alternating freeze-thaw and cyclic loading (FTF) using acoustic emission (AE) and ultrasonic testing techniques. The sandstone specimens are subjected to five cycles of freeze-thaw followed by ten cycles of low stress loading-unloading (stress lower than 40% of the rock's ultimate strength), referred to as the first stage of alternating action (Stage 1). This process is repeated several times until the failure of the rock sample, simulating the alternating effects of multiple freeze-thaw cycles and cyclic loading that may occur in cold region engineering. The research findings are as follows: With the progress of freeze-thaw cycles and alternating action of cyclic loading, the secant modulus and wave velocity of the rock generally show a decreasing trend. The first stress loading-unloading in each stage significantly enhances the secant modulus and longitudinal wave velocity of the freeze-thawed rock. The residual strain generated by the first loading-unloading is significantly higher than that of subsequent loading-unloading. Prior to rock failure, both the secant modulus and wave velocity experience significant decreases. These two phenomena serve as indicators for determining the critical failure of the rock, allowing the classification of rock states into safe, critical, and failure states. Freeze-thawed sandstone exhibits two significant acoustic emission characteristics during the cyclic loading phase: an initial loading phase is accompanied by a surge in the number of acoustic emission events, while after the first loading-unloading, the number of acoustic emission events stabilizes, forming a wave-like pattern of change. Additionally, an AE index is proposed to evaluate the degree of damage to the rock after each freeze-thaw stage, and its effectiveness is verified. The AE index reflects a gradual increase in freeze-thaw damage, followed by a sudden intensification, leading to failure and exhibiting three stages of evolution. An AE index of 2.2 is defined as an early warning indicator, while an AE index of 2.95 is defined as the failure indicator for the rock. Finally, based on experimental data, a damage evolution model is proposed, which describes the entire process of sandstone damage and effectively reflects the three-stage characteristics of rock freeze-thaw damage evolution.
Higher Bernstein Polynomials and Multiple Poles
Authors: BARLET Daniel
Published: July 2023

The goal of this paper is to give a converse to the main result of my previous paper [12], so to prove the existence of a pole with an hypothesis on the Bernstein polynomial of the (a,b)-module generated by the germ ω ∈ Ωn+1. A 0 difficulty to prove such a result comes from the use of the formal completion in f of the Brieskorn module of the holomorphic germ f : (Cn+1, 0) → (C, 0) which does not give access to the cohomology of the Milnor’s fiber of f, which by definition, is outside {f = 0}. This leads to introduce convergent (a,b)-modules which allow this passage. In order to take in account Jordan blocs of the monodromy in our result we introduce the semi-simple filtration of a (convergent) geometric (a,b)-module and define the higher order Bernstein polynomials in this context which corresponds to a decomposition of the ”standard” Bernstein polynomial in the case of frescos. Our main result is to show that the existence of a root in −α − N for the p-th Bernstein polynomial of the fresco generated by a holomorphic form ω ∈ Ωn+1 in 0 the (convergent) Brieskorn (a,b)-module Hn+1 associated to f, under the hypothesis 0 that f has an isolated singularity at the origin relative to the eigenvalue exp(2iπα) of the monodromy, produces poles of order at least p for the meromorphic extension of the (conjugate) analytic functional, for some h ∈ Z: 1􏰌 ̄ω′ ∈ Ωn+1 􏰐→ |f|2λf−hρω ∧ ω ̄′ 0 Γ(λ) Cn+1 at points −α − N for N and h well chosen integers. This result is new, even for p = 1. As a corollary, this implies that in this situation the existence of a root in −α − N for the p-th Bernstein polynomial of the fresco generated by a holomorphic ∗Barlet Daniel, Institut Elie Cartan UMR 7502Universit ́e de Lorraine, CNRS, INRIA et Institut Universitaire de France, BP 239 - F - 54506 Vandoeuvre-l`es-Nancy Cedex.France.e-mail : daniel.barlet@univ-lorraine.fr 1 form ω ∈ Ωn+1 implies the existence of at least p roots (counting multiplicities) for 0 the usual reduced Bernstein polynomial of the germ (f, 0).In the case of an isolated singularity we obtain that for each α ∈]0, 1] ∩ Q the biggest root −α − m of the reduced Bernstein polynomial of f in −α − N produces a pole at −α − m for some h ∈ Z for the meromorphic extension of the distribution 1 ̄□ −→ Γ(λ)|f|2λf−h□.
AMS classification. 32 S 25; 32 S 40 ; 34 E 05
Prediction of the Polyacrylamide Adsorption onto Calcite Surface
Authors: Silvino Pedro Felipe Gadelha , Souza Carlos Henrique Linhares , Nascimento Maria Thereza Saldanha Fontenele Sousa , Oliveira José Carlos Alexandre , Lucena Sebastião Mardônio Pereira
Published: July 2023

Polymer flooding in petroleum reservoirs is one of the main techniques used for enhanced oil recovery. However, the retention of polymers on the surface of rock pores by adsorption has been one of the major problems that affect the efficiency of the process and cause a reduction in the formation permeability, especially in carbonate reservoirs. A more detailed analysis of the mechanisms involved in the adsorption of the polymer on the rock surface can be performed through molecular simulation. The present study used a combination of molecular dynamics and Monte Carlo techniques to evaluate the adsorption of polyacrylamide on calcite. Two models of polyacrylamide molecules were constructed, with 30 and 50 monomers. The behavior of these molecules in the aqueous phase was determined through molecular dynamics simulations, obtaining stable conformations of the polymer in water. With the stabilized polyacrylamide structures obtained, we performed Monte Carlo simulations to study the adsorption of polyacrylamide on calcite surface. Values of maximum adsorbed amount and molecular conformations with different polymeric chain sizes and at different concentrations showed good agreement with experimental results obtained from the literature.
Estimation of Surface Runoff Using SCS-CN Remote Sensing and GIS in Sanjab Watershed
Authors: Mujeeb Mujeebullah
Published: July 2023

Accurate estimation of surface runoff is not only an important task for planning and designing hydro technical structures but also important for proper watershed management. The Watershed is a perfect unit for planning and managing land and water resources. The catchment's direct runoff is influenced by rainfall, land cover, and type of soil. The most widely used technique for calculating runoff from rainfall is the curve number method (SCS-CN). The curve number is based on the properties of the soil and land usage. This study was carried out in the Sanjab watershed, located in the Enjeal district of Herat province, Afghanistan, using remote sensing and GIS. The reason for selecting this area is that in 2021 the ministry of Agriculture Irrigation and livestock intended to create about 14,000 hectares of pistachio commercial gardens in the mentioned area, but they didn’t find a reasonable source for its irrigation the only source available here were Sanjab River and its surface runoff to be stored and used, So I decided to study the existence watershed and this will help in existence flood water management and it’s effective usage for pistachio garden, The total area of watershed 181km2 or 18080 hectares. Soil maps, land use maps, and slope maps were generated in GIS10.4 Environment. The Soil Conservation Service- Curve Number (SCS-CN) method is used here as a lumped model; in this research, ten-year (2012–2021) rainfall data was used to obtain the amount of surface runoff in Sanjab watershed at the result the highest volume of surface runoff was in 2019 about 17,298,885 cubic meters and the lowest was in 2014 about 9,061,754 cubic meters and the average amount was obtained 12,702,138 cubic meters per year.
Effects of Different Grades of Drought on Vegetation in Ecologically Fragile Karst Areas of Guangxi
Authors: Yanli Chen , Ying Xie , Mingzhi Li , Min Xie , Weihua Mo
Published: July 2023

Drought is a major threat to rocky desertification control and ecological restoration in ecologically fragile karst areas of Guangxi Province. In this study, the normalized difference vegetation index (NDVI), fractional vegetation cover (FVC) and net primary productivity (NPP) were selected as vegetation remote sensing parameters, and the spatial response characteristics of different types of vegetation in karst areas of Guangxi Province to light, moderate, severe and extreme drought were analyzed to provide scientific basis for the evaluation of the impact of drought on vegetation in karst areas. The results are as follows: (1) NDVI, FVC and NPP showed a fluctuating increasing trend from 2000 to 2022, and the increasing rates were 0.058, 6.90%, and 43.3gC.m-2 per decade respectively. During this period, the number of light, moderate and severe drought days showed a decreasing trend, but the number of extreme drought days tended to increase. (2) The negative correlation of NDVI, FVC and NPP and drought increased from moderate to extreme drought, and from light to extreme drought, the negative correlation between NDVI and FVC and drought decreased, while that of NPP increased. (3) Light and moderate drought had obvious negative effects on Chinese fir and broad-leaved forest, while severe and extreme drought had obvious negative effects on eucalyptus and bamboo forest.
SFA-Net: Scatter-Fusion Attention Network for Person Re-identification
Authors: Wang Shanshan , Chen Ying
Published: July 2023

The utilization of attention mechanisms has demonstrated promising outcomes in diverse vision tasks, like the Person re-identification (re-ID) task. In the context of person re-ID, the acquisition of effective convolutional features through attention mechanisms plays a crucial role. However, person re-ID presents a unique challenge as individuals manifest themselves through multiple body regions simultaneously. Consequently, a holistic approach is necessary to encode high-order interactions among local features for accurate recognition. To address these challenges, we propose the Scatter-Fusion Attention Network (SFA-Net) as a viable solution. The scatter operation involves the instantiation of multiple attention blocks, enabling simultaneous attention across multiple body areas and the creation of attention maps for these regions. Subsequently, the Fusion operation redistributes these attentions to multiple locations before merging the feature maps into a comprehensive one. SFA-Net effectively leverages the attention mechanism to scatter and fuse attention blocks, facilitating the flow of information among them. The SFA mechanism incorporates spatial and channel-wise attention mechanisms, allowing for a comprehensive emphasis on foreground objects and effective elimination of background clutter, in contrast to conventional attention learning that considers only current features at a time. Extensive experimental results verified that SFA-Net achives state-of-the-art person re-ID on two datasets(Market-1501 and DukeMTMC-reID).
Piloting “From the Inside Out” - a toolkit addressing tuberculosis-related self-stigma: A feasibility study
Authors: Macdonald Stephen H-F , France Nadine Ferris , Hodgson Ian , Ali Fadhil , Dewi Christa , Abdurrakhman Iman , Runtu Yeremia Mozart , Juan Alva , Sugiharto Jhon , Byrne Elaine , Conroy Ronan
Published: July 2023

Self-stigma among people who have tuberculosis (TB) can contribute to non-adherence to medication and disengagement from care. It can manifest in feelings of worthlessness, shame, and guilt, leading to social withdrawal and disengagement from life opportunities. Self-stigma may also affect families of those who have TB, or healthcare workers who treat them. However, few interventions addressing TB self-stigma exist to-date. We therefore piloted the delivery of a toolkit of psychosocial interventions using a “train the trainers” approach with six staff members of a TB-focused NGO and partner organisations in Jakarta, Indonesia. These trainers could then disseminate the toolkit among community partner organisations. Local staff involvement throughout the study supported translation and adaptation to enhance cultural and language appropriateness. Over a two-day training-of-trainers workshop, the NGO staff were familiarised with the mode of delivery of the toolkit, which they then delivered via a four-day participatory workshop with 22 representatives of partner organisations working among communities affected by TB. The newly-trained NGO staff delivered the toolkit to the participants, who self-reported significant increases in knowledge and efficacy around TB self-stigma post-intervention compared to baseline (Z = 1.991, p = 0.047). The participants' levels of self-compassion were also significantly higher post-workshop (Z = 2.096, p = 0.036), however, this effect was not maintained at three-month timepoint. There was also a significant increase post-workshop in the participants' Ryff dimensions of psychological wellbeing in the dimension of positive relationships with others (Z = 2.509, p = 0.012) and self-acceptance was significantly higher at 3-month follow-up (Z = 2.877, p = 0.004). Environmental mastery was significantly lower at 3-month follow-up (Z = 2.670, p = 0.008). Observed changes in recipients’ self-reported levels of knowledge and efficacy, self-compassion, and psychological wellbeing may warrant further investigation into the best modalities for toolkit delivery (frequency, dose, duration) and support for individuals as they progress through the TB treatment journey.
Nonlocal response of planar plasmonic layers
Authors: Burda Milan , Richter Ivan , Kwiecien Pavel
Published: July 2023

Nonlocal interactions of plasmonic nanostructures are currently beingintensively investigated. It is generally accepted that nonlocal interactionsare most pronounced on structures with nanometer unit sizes andaffect the shape of spectral functions of characterizing quantities in theresonance region. Numerical analysis of nonlocal phenomena is very complicatedand it is advantageous to use it for the analysis of geometricallymore complex structures. For some simple structures it is possible to findanalytical solutions which can then be used, among other purposes, tobuild semi-analytical approaches for the analysis of some more complexstructures. This article is focused on the efficient description of nonlocalmanifestations of a planar metal layer using a hydrodynamic model. Thismodel is further extended to the more general case of two adjacent nonlocallayers (bilayers). The results for both single layer and bilayer case arepresented and discussed in detail. Also, one of the here presented importanttechnical results are the transfer matrices for the nonzero normalcomponent of the current densities at the interfaces of the metal layer.
Efficacy and safety of pyrotinib for patients with HER2-positive advanced breast cancer : a retrospective multicenter real-world study
Authors: Li Yongxia , Li Yong , Li Taolang , He Mingyuan , Chang Jianying , Cao Hui , Luo Daiqin , Lv Junyuan , Zou Yunbi , Zheng Yuyan , Wang Hongxia , Ran Li , Yang Feiyue , Huang Li , Chen Xiaoming
Published: July 2023

Purpose
The incidence of breast cancer ranks first among female malignancies that affect women's health. Human epidermal growth factor 2 (HER2) positive breast cancer accounts for 20% − 30% of the invasive breast cancer, which is related to the poor prognosis of the tumor. This study aimed to observe the efficacy and safety of pyrotinib in HER2-positive advanced breast cancer in the real world.
Methods
This multicenter retrospective study was performed on the clinical data of HER2-positive advanced breast cancer patients treated with pyrotinib from March 2019 to April 2022. Progression-free survival (PFS), overall survival (OS), objective response rate (ORR), disease control rate (DCR), clinical benefit rate (CBR) and occurrence of adverse events were observed after treatment, and possible predictors of efficacy were explored.
Results
A total of 91 female patients enrolled, with a median age of 51 years (range, 30–76), a median PFS of 14.3 months (95%CI: 8.8–19.8), and a median OS of 30.0 months (95%CI: 23.8–36.2). Short-term efficacy showed that 4 cases of complete remission (CR), 61 cases of partial remission (PR), 23 cases of stable disease (SD) and 3 cases of progression disease (PD) were identified, and the ORR, DCR and CBR were 71.4%, 96.7% and 74.7%, respectively. The main treatment-related adverse event was diarrhea. Log-rank analysis showed a significant difference in OS between patients with liver metastases and patients with non-liver metastases (15.8 months vs 31.4 months, HR = 2.30, P < 0.05). The results of the Cox regression model indicated that the number of pyrotinib treatment lines was an independent risk factor affecting PFS and OS of patients (HRPFS =1.81, HROS =1.91, P < 0.05).
Conclusions
Pyrotinib-based regimens were safe and effective in the treatment of HER2-positive advanced breast cancer, and the earlier use was better. Pyrotinib-based therapy might have some advantages in patients without liver metastases. This study set the stage for further exploration of the treatment paradigm of pyrotinib.
Quantitative Shaking Evaluation of Bracing-Strengthened and Base Isolated Building using Seismic Intensity Level (SIL)
Authors: Egatama H F , Wariyatno N G , Han A L , Gan B S
Published: July 2023

This paper presents a new and comprehensive design philosophy for evaluating earthquake-induced shaking and vibrations based on Japan Meteorological Agency (JMA) formulas. The goal of determining Seismic Intensity Level (SIL) is to identify measures or actions that can minimize the risk of human casualties during earthquakes. This study aims to assess the application of SIL as an evaluation tool for the seismic aspect of a building. Three categories of building model, which are existing building (a 15x12x18.1 m frame building without strengthening), bracing-strengthened buildings, and Base Isolated buildings, were evaluated. The evaluation criteria are the maximum acceleration of the roof, energy dissipation, and measured Seismic Intensity Level (m-SIL) according to JMA calculation. Models were subjected to the 1940 El Centro seismic wave of the North-South (N-S) orientation as the ground motion. From this study, the evaluation using Seismic Intensity Level (SIL) provides more consistency and is simpler to comprehend. The application of SIL as an evaluation tool for comparing the performance of the two strengthening methods proves that the base isolation (BI) method performs safer shaking of the building than bracing strengthening. An indicative chart is also proposed to help designers generatecost estimation of SIL.
Enhancement in selectivity of trivalent Am over Cm by modulating donor centres of aza- macrocyclic ligands: An implication of their differences in bonding
Authors: Chattaraj Saparya , Bhattacharyya Arunasis
Published: July 2023

Efficient management of the high-level liquid waste (HLW) generated during the reprocessing of nuclear fuel involves mutual separation and transmutation of the minor actinides like Am and Cm, which are chemically very similar. In the present work, an in-silico analysis of the bonding of Am(III) and Cm(III) ions with donor center modulated azacrown based ligand, i.e., a ligand formed by replacing the four ‘O’s of the azacrown macrocycle in N,N’-bis[(6-carboxy-2-pyridyl)-methyl]-1,10-diaza-18-crown-6 (L1) with four ‘S’s (L2) is carried out using relativistic density functional theory to develop a deeper understanding of the impact of both, soft donors as well as the cavity effects on the separation of these metal ions. The subtle differences in the bonding is brought about by the covalent interaction of the metal and the aza-macrocyclic O and S donors. The electron donation from the ligand is mostly accepted in the metal 6d orbitals and minimally to the 5f orbitals. But the f-orbital participation plays the crucial role in bringing about the subtle difference in the bonding between Am(III) and Cm(III) ions with the ligands. The trivalent Cm ion with half-filled initial f7 configuration shows resistance in participating in bonding as was observed from NPA, QTAIM, NBO and DOS analyses. Whereas, the Am(III) ions having f6 configuration are eager to accept f-electrons to achieve the stable half-filled configuration. The energetics elucidated that both L1 and L2 ligands are Am selective. But the extraction capacity and selectivity is higher for the L2 ligand. The Am selectivity can be attributed to the significant covalent interaction of S donors which have better electron donating capacity (than O) to the electron deficient Am(III) ion. This study is anticipated to throw some light on the implication of the bonding features on their separation.
The Utility of Routine MRI Surveillance Screening in Pediatric CNS Tumor Survivors
Authors: Cacciotti Chantel , Lenzen Alicia , Self Chelsea , Pillay-Smiley Natasha
Published: July 2023

Purpose
Surveillance magnetic resonance imaging (MRI) is routinely used to detect recurrence in pediatric central nervous system (CNS) tumors. Frequency of neuroimaging surveillance varies with no standardized approach.
Methods
We sought via a single institution retrospective cohort study to evaluate the frequency of recurrence identified by surveillance neuroimaging versus those detected clinically.
Results
This study included 476 patients; the majority diagnosed with a low-grade glioma (LGG) (n = 138; 29%), high grade glioma (HGG) (n = 77; 16%), ependymoma (n = 70; 15%) or medulloblastoma (n = 61; 13%). Patients with LGG, HGG and ependymoma more commonly had multiply recurrent disease (p = 0.08), with those with ependymoma demonstrating two or more relapses in 49% of cases. Recurrent disease was identified by imaging more often than clinical symptoms (65% vs 32%; p = < 0.01). Mean time to first relapse and subsequent relapse for the entire cohort was 30 months (range 1 day − 24.8 years) and 19.5 months (range 1 week-19.6 years), respectively. Patients diagnosed with meningioma demonstrated the longest mean time to first relapse (74.7 months), whereas those with Atypical Teratoid Rhabdoid Tumor (ATRT) and Choroid plexus papilloma tended to have the shortest time to relapse (8.9 months and 5.5 months, respectively). Overall, 22 patients sustained the first relapse > 10 years from initial diagnosis (9 LGG, 4 medulloblastoma, 3 meningioma, 2 germ cell tumor, 1 pineoblastoma, 1 craniopharyngioma, and 2 other).
Conclusion
With a higher tendency towards detection of tumor recurrence/progression on MRI surveillance in comparison to clinical progression, surveillance imaging should be considered in routine follow up of pediatric CNS tumor survivors. With some relapses > 10 years from initial diagnosis, imaging beyond this time point may be useful in particular tumor types.