bluuebunny/crossref_metadata_2025 huggingface dataset:
Reducing musculoskeletal complaints and fatigue through participatory ergonomics on the table and chair design of participants of Halal Assurance System (HAS) training in LPPOM MUI of Banten, Indonesia
Authors: Susihono Wahyu , Rodani Rodani , Adiatmika I Putu Gede
Published: November 2020

Background: Halal Assurance System (HAS) training is mandatory for industries that will apply for halal certification at LPPOM MUI of Banten Province. In some trainings, the participants felt uncomfortable which can be seen from the level of fatigue and complaints caused by an uncomfortable sitting position due to poor design of tables and chairs. This condition is very detrimental to participants.Methods: This treatment by subject design study did from April to November 2019. The participants were who attended the HAS Training-23000 that fulfilled the inclusion and exclusion criteria. Samples then grouped into three group with different condition in each. We took indoor environment data and each sample about sample characteristics and business characteristics. Muscle complaints took by subjective questionnaires before and after training. The data analyzed by SPSS and p<0.05 was significant.Results: Total 120 participants were included consisting of 40 participants in each condition. Â The indoor environment conditions in the three conditions are the same (p>0.05). There were significant reduce of score of musculoskeletal complaints and fatigue before and after trainings in each condition (p<0.0001). Seats with multilevel arrangement (condition III) have the lowest value of musculoskeletal complaints and fatigue.Conclusions: The smooth communication among participants influences the speed in implementing participatory ergonomics. The use of tables and chairs with a seating capacity of 6 people/table is the most effective when compared to others. The application of participatory ergonomics can reduce musculoskeletal complaints and fatigue of participants of the Halal Assurance System.
Penile necrosis due to calciphylaxis in peritoneal dyalisis patient: a case report
Authors: Dahril Dahril , Manurun Fitro , Pratama Rovy
Published: November 2020

Introduction: Calciphylaxis (or calcific uremic arteriolopathy) is a life-threatening condition that affects 1â€“4% of patients with end-stage renal disease (ESRD). Penile necrosis is one of the complications of calciphylaxis that occur in ESRD patients undergone haemodialysis. Although rarely happen, this condition is potentially life-threatening and usually has a poor prognosis. It is associated with diabetes mellitus (DM), cholesterol embolism. The treatment varies, from surgical to conservative, and is usually depends on patientâ€™s general condition.Case presentation: A 41-years-old male, known to have ESRD and underwent hemodialysis for 1 year in 2014, but has been switched to peritoneal dialysis ever since, presented with complaints of severe pain, purulent and progressive necrosis of glans penis within the last two months, and history of long-term DM and hypertension. Physical examination showed that the patient was alert, with blood pressure of 141/80 mmHg, pulse rate of 88 bpm, respiration rate of 20 times per minute, and temperature of 36.8ÂºC. A yellow purulent tissue was noticed over the glans penis, foul-smelling discharge was observed from urethra and undersurface of penile lesion. Laboratory examination showed elevated calcium level of 7.3 mg/dL. Ultrasound revealed multiple calcifications at the base of penis, hypoechoic lesion, nearly circular, irregular border, likely sac with thin wall, attached to the gland penis, and filled with exudate. Doppler confirmation showed avascular area. The patient was treated with partial penectomy, debridement, and antibiotic.Conclusion: Calciphylaxis in peritoneal dialysis patients as reported in this case was rarely found. Although the treatment is still debatable, however, we decided to impose surgical approach in this patient along with antibiotics. Despite its poor prognosis, the patient in this case showed improvement after the procedure.
Class model of family planning based on predisposing, enabling and reinforcing factors in improving knowledge, attitude, family support and use of long-term contraception methods in fertile age pair of high risk
Authors: Rohani Rohani , Wirawan I Made Ady , Satriyasa Bagus Komang , Duarsa Dyah Pradnya Paramitha , Irianto Irianto
Published: November 2020

Introduction: This study aims to prove the model of family planning classes based on predisposing, enabling and reinforcing factors to increase knowledge, attitudes, family support, and the use of long-term contraception methods in high risk fertile age pairs.Method: The design used for this study is the Community Trial with the Randomized Pretest-Posttest Control Group Design approach. The sample in this study were couples of childbearing age who had one or more high risk criteria (age <20 years, age> 35 years, number of children> 3 and birth distance <2 years) as many as 150 respondents as an intervention group (family planning class model based on predisposing, enabling and reinforcing factor) and 150 respondents as a Control group (Conventional Family Planning Class Model). This intervention was carried out for 6 months. Data collected includes data on knowledge, attitudes, family support, and use of contraception methods. Data were analyzed using Chi-Square test.Result: The family planning class model based on predisposing, enabling and reinforcing factors effectively increases knowledge (p=0.000), attitudes (p=0.000), family support (p=0.037), and long-term contraception method use (p=0.000).Conclusion: The family planning class model based on predisposing, enabling and reinforcing factors effectively increases knowledge, attitudes, family support, and the use of long-term contraception methods in high risk fertile age couples
Forensic investigation in a multiple trauma deceleration case due to road traffic accidents
Authors: Suryadi Taufik , Kulsum Kulsum
Published: November 2020

Background: Road traffic accidents (RTA) are the series of events from road events that are unexpected, and always cause damage to objects, injury and even death. Factors for the occurrence of RTA can be in the form of vehicle, road and human. In this case RTA occurred because of human negligence and road factors. The human factor in the form of the driver driving a vehicle at high speed with an estimated 160 Km/h at night, the other factor is the driver is sleepy or tired. Road factors contribute to the occurrence of accidents due to wide and declining road segments cause the driver unable to control vehicles at high speed, quiet roads and inadequate street lighting conditions. This accident resulted in a heavy damage to the vehicle and all passengers died. The explanation of the causes and patterns of death is important in forensic investigations of RTA victims.Case description: A case of RTA with multiple deceleration injuries was reported. This traffic accident case involved a minibus car speeding and crashing into a bulk cement tank truck that was stopped on the Banda Aceh-Meulaboh National Road, on 30 October 2016 around 04.15 a.m which caused all passengers of minibus died. The speeding minibus car suddenly stopped and hit the back of the tank truck, as a result the body moving at the speed of the vehicle suddenly slowed down (deceleration) causing multiple trauma. The effects on the bodies of the victims varied in the form of open head trauma, closed head trauma, chest trauma, abdomen and extremities. The mechanism and cause of death of the victims was massive bleeding in several organs, especially the head (traumatic brain injury) and chest (rib fracture).Conclusion: Forensic investigations are very useful in determining the cause of death, mechanism of death, manner of death, magnitude of the impact, direction, speed, and nature of the traffic accident.
Factors affecting the mini-mental state examination (MMSE) score in the epilepsy patients in Aceh, Indonesia
Authors: Lestari Nova Dian , Rizkidawati Rizkidawati , Shafira Cut Prita , Suherman Suherman , Mutiawati Endang
Published: November 2020

Background: Epilepsy patients in developing countries is quite high. A person can have epilepsy within a certain time limit, but also not a few people who survive with this condition for life. This situation will affect cognitive function. Cognitive function impairment in epilepsy patients can be triggered by various factors related to aetiology, clinical, and others. Therefore, we tried to find the factors that influence the cognitive function in epilepsy patients.Methods: This study was an observational analytic study with a cross-sectional design. The study was conducted using primary data obtained from direct interviews and MMSE examination and secondary data obtained from medical records to confirm the diagnosis of epilepsy. Samples were collected based on the diagnosis of neurologist in the patient's medical record at the Regional General Hospital Dr. Zainoel Abidin Banda Aceh from October to December 2019. This study involved thirty-four epilepsy patients.Result: There were cognitive function decreased in recalling 47,1% and 26,5% in Attention and calculation. The relationship between the frequency of seizure (p = 0.028) and therapy (p = 0.012) on theÂ  MMSE .Conclusion: Politherapy was the dominant factor affecting the MMSE score of epilepsy patients.
Evaluation of risk factors in patients with ventilator-associated pneumonia caused by Acinetobacter baumannii
Authors: Baran Ali Ä°rfan , Ã‡elik Mehmet , Arslan Yusuf , DemirkÄ±ran Hilmi , SÃ¼nnetÃ§ioÄŸlu Mahmut , SÃ¼nnetÃ§ioÄŸlu Aysel
Published: November 2020

Purpose: Â Ventilator-associated pneumonia is a significant disease with high mortality rates. Acinetobacter baumannii is one of the most critical pathogens leading to ventilator-associated pneumonia. This study aims to evaluate the underlying risk factors in patients diagnosed with ventilator-associated pneumonia caused by Acinetobacter baumannii, who were followed in intensive care units of our hospital.Patients and Methods: Â The data of 112 patients diagnosed with ventilator-associated pneumonia caused by Acinetobacter baumannii, who were followed in Intensive Care Units other than Pediatric Intensive Care UnitÂ of our hospital from 2013 to 2017, were evaluated retrospectively.Results: Of the cases included in our study, 70.5% were male, and 29.5% were female patients. Of the cases, 87.5% were followed in Anaesthesiology and Reanimation Intensive Care Unit. The most common modifiable risk factors are mechanical ventilation, antacid use, and the most common non-modifiable risk factors were the presence of trauma and a history of cardiovascular disease.Conclusion: Ventilator-associated pneumonia is a clinical condition with high mortality and morbidity in intensive care units. Incidence and mortality of ventilator-associated pneumonia can be reduced through the implementation of some necessary policies for the prevention of ventilator-associated pneumonia and the practices for the reduction or elimination of modifiable risk factors.
The correlations of knowledge, attitude, and smoking behaviour with smoking cessation effort at coffee shops in Banda Aceh, Indonesia
Authors: Alfianto Muhammad Faris , Habibie Yopie Afriandi , Ridwan Muhammad , Zulfikar Teuku , Salawati Liza
Published: November 2020

Background: The highest prevalence of smokers aged 15 years and above is occupied by the Republic of Indonesia with a percentage reaching 76.2%. Aceh Province leads the highest prevalence of smokers aged of â‰¥10 years (24.0%) compared to the mean of Indonesia (24.3%). Researchers are encouraged to discuss about smoking cessation efforts that might be carried out by the knowledge, attitudes, and smoking habits in the people of the City of Banda Aceh. Â Methods: This study aims to find out the correlation between knowledge, attitudes and smoking behaviour towards the smoking cessation efforts in Banda Aceh. Using a cross-sectional design with accidental sampling technique at six most visited coffee shops in Banda Aceh. All the data were collected using GATS (Global Adult Tobacco Surveillance) questionnaire that had been modified, and conducted by direct interview. All respondent had received signed informed consent.Results: A total of 111 active smokers was collected. This study indicated that smokers have average smoking cessation efforts more than 30 days (41.4%), dominantly well educated (60.4%), neutral attitude (72.1%), and mild smokers (79.3%). We also found that smoking cessation efforts were influenced by knowledge (p=0.036), attitudes (p=0.025), and smoking behaviour (p=0.001).Conclusion: There are correlations between knowledge, attitudes, and smoking behaviour towards the smoking cessation efforts in Banda Aceh.
Effect of pirfenidone and its combination with 5-fluorouracil on keloid fibroblast proliferation and collagen deposition: in vitro study
Authors: Dharmawan Nugrohoaji , Hartati Agung Triana , Julianto Indah , Kariosentono Harijono
Published: November 2020

Background: Keloid is a fibroproliferative disease in which its etiology remains unknown. Various therapy modalities have been improved, but none of them gives a satisfying outcome. Pirfenidone (PFD) is a commonly used drug in pulmonary fibrotic diseases, which has an anti-fibrotic effect. 5-fluorouracil (5-FU) is one of the keloid therapy choices that has long been used. This study aimed to investigate PFD's effect and its combination with 5-FU on fibroblast proliferation and collagen deposition.Methods: This experimental study using post only control group design was conducted by comparing PFD in various doses (0.5, 1.0, 1.5, 2.0, 3.0 mg/ml) and its combination with 5-FU on keloid fibroblast proliferation and collagen deposition. We used MTT (3-[4,5-dimethylthiazol-2-yl}-2,5diphenyl tetrazolium bromide) and Sirius Red assays to measure the fibroblast proliferation and collagen deposition, respectively. The statistical analysis used one-way ANOVA with p-value p<0.05 was considered significant.Results: The combination of PFD 3.0 mg/ml + 5-FU 1.0 mg/ml had more significant effect on inhibiting fibroblast proliferation as well as decreasing collagen deposition compared to 5-FU only (p<0.043). PFD 1.0 mg/ml + 5-FU 1 mg/ml as well as PFD 1.5 mg/ml+ 5-FU 1 mg/ml are more effective in inhibiting fibroblast proliferation and lowering collagen deposition than PFD only with p values of <0.001 and <0.000, respectively.Conclusion: In general, PFD, as well as 5-FU, are effective in inhibiting fibroblast proliferation and decreasing collagen deposition in keloid. However, the combination of both has a better effect compared to PFD or 5-FU monotherapy.
Brain alteration in chronic pain and the relationship with pain score
Authors: Mutiawati Endang , Syahrul Syahrul , Musadir Nasrul
Published: November 2020

Brain volume alteration in chronic pain has been studied in many studies. Most of the reviews were reported that the brain volume decrease in chronic pain, although there were some studies reported that the brain volume increased. The alteration mechanism of brain volume was certain unknown, maybe it caused by nerve hyperactivity in the pain pathway, from nociceptor to post-central gyrus. The alteration of substantia grisea volume decreased is interested to know, which it is occurring in the location of the pain pathway of substantia grisea in the brain. This mechanism was one of the bodyâ€™s ways to reduce the pain score, which then it makes the painless.
Aortic enlargement: a case report of cadaveric heart and great vessels dimensions
Authors: Parwanto Mauritius Lambertus Edy , Mediana Dian , Samara Diana , Wartono Magdalena , Pakpahan Alfred , Widyatama Haryo Ganeca
Published: November 2020

Aortic enlargement is not an uncommon incidental finding with potential omission of clinical implications. During routine dissection in the middle of the thorax, there was an incidental finding of a disproportionately enlarged aorta in comparison to normal-sized heart at gross observation despite normal anatomy in local and adjacent structures. Incidental finding of aortic enlargement should not be disregarded as it might contribute to pathological processes. The use of indices could give a more comprehensive appraisal of cardiovascular system dimensions.
C-reactive protein levels as a predictor for anastomotic success in post-operative intestinal resection surgery
Authors: Basuki Isa , Kusuma Muhammad Ihwan , Suprapto Bambang , Hendarto Joko
Published: November 2020

Background: C-reactive protein (CRP) is widely used as an early predictor of anastomotic complications such as anastomotic leakage (AL) after abdominal surgery. There are no data available regarding the AL in A.W.Sjahranie Regional General Hospital (RSUD AWS). This study analyzed the CRP values and their relationship with AL after bowel resection and anastomosis surgery at RSUD AWS Samarinda.Methods: This is an observational analytic cross-sectional study. Sample data were collected from the medical records of 40 patients who underwent bowel resection between May and December 2019. Patients were between 18-75 years old and showed clinical signs of AL. CRP laboratory data were examined on the fifth-day post-operation. After tabulation, the data were analyzed using Chi-square (Fisherâ€™s exact) test, t-test, and receiver operating characteristic curve analysis.Results: The average sample age was 46.3 Â± 1.31 years, with a 1:1 male and female ratio. The analysis showed that an increase in CRP values and white blood cell counts was not related to AL (p > 0.05). The mean CRP value of patients with AL (48.0Â±0.00 mg/L) was not significantly different if compared to non-AL patients (25.89 Â± 18.93 mg/L) (p = 0.139). The CRP cut-off value of 36 mg/L had 100% sensitivity, 60.5% specificity, 71.7% positive predictive value and 100% negative predictive value with an area under the curve of 0.80 (p=0.153). These results showed that the CRP cut-off value of 36 mg/L couldn't be used as a predictor of AL.Conclusion: CRP level of 36 mg/L can be used as a predictor of non-AL; therefore, it can be used as a criterion for patient discharge.
Analysis of the effect of knowledge, attitude, and skill related to the preparation of doctors in facing industrial revolution 4.0
Authors: Sudiwedani Ayu , Darma Gede Sri
Published: November 2020

Backgrounds: Human resource development in terms of the knowledge, attitude, and skills of a doctor is important in a digital era and to face the industrial revolution 4.0. This study aims to analyze the effect of knowledge, attitude, and skills on doctor behavior and the impact of doctor behavior on its readiness in facing the industrial revolution 4.0.Â Methods: This study uses descriptive-quantitative methods with regression analysis techniques.Results: The results of the study based on Regression Weight (Î³) show that knowledge has no significant negative effect on behavior; attitude does not have a significant positive impact on behavior; skill does not have a significant positive effect on behavior, and behavior significantly has a positive effect on the readiness of doctors.Â Conclusion: The results and discussion show that hospitals can use the structural equation model in analyzing knowledge, attitude, skill, and behavior problems to increase the doctor's readiness, and strengthening the doctor's behavior needs to develop doctors' attitudes and skills.
The hepatoprotective effect of cacao beans whole extracts (Theobroma cacao L.) in oxidative stress mice
Authors: Wiryanthini Ida Ayu Dewi , Sutadarma I Wayan Gede , Dewi Ni Wayan Sucindra , Surudarma I Wayan
Published: November 2020

Background: Increased production of reactive oxygen species (ROS), causing accumulation of oxidative damage. Carbontetraclorida (CCl4) is known as a toxic material and causing hepatocellular damage initiated by oxidative stress, which increased blood serum glutamic pyruvic transaminase (SGPT) concentration. Cacao beans (Theobroma cacao L.) extracts have antioxidant properties from flavonols, consisting of catechin, epicatechin, and procyanidin. This study aims to investigate the effect of hepatoprotective of cacao beans (Theobroma cacao L.) extracts in oxidative stress mice induced by CCL4.Â Methods: The study was conducted at the Department of Biochemistry and Department of Pharmacology and Therapy, Faculty of Medicine Udayana University using the Pretest-Postest Control Group Design. About 20 male mice were divided into 4 groups, as control or placebo group (P0), intervention group by 15 mg extracts of cacao beans (P1), 30 mg (P2), and 60 mg (P3) for 7 days. On the eight-day induced by 0,55 mg/gram mice bodyweight of CCl4. All groups were examined for blood SGPT concentration before and after the intervention. Data were analyzed using SPSS version 20 for Windows. Results: The SGPT level prior to the administration of cacao bean extract and CCl4 was 18.56Â±0.19 Âµ/L in P0 group, followed by 18.41Â±0.28 Âµ/L (P1), 18.36Â±0.21 Âµ/L (P2), and 18.16Â±0.47 Âµ/L (P3), but statistically not significant (p=0.260). However, after CCl4 administration, the SGPT levels were 38.63Â±0.37 Âµ/L in P0 but significant decrease in the P1 (28.14Â±0.34 Âµ/L), P2 (20.72Â±0.35 Âµ/L), and P3 (18.68Â±0.25 Âµ/L) following cacao beans whole extracts administration (p=0.000).Conclusion: This study concluded that cacao beans extracts administration could inhibit the oxidative stress and protect hepatocellular damage induced by CCl4 by decreasing the blood SGPT concentration.
The functional and physical state of the anal sphincter complex in the patients with rectal prolapse in the post-surgery period
Authors: Imanova Solmaz Soltan
Published: November 2020

Purpose: The work was aimed at comparative studying of the functional and physical state of the patients with rectal prolapse after surgical treatment with various surgical techniques and at identifying the most optimal procedure technique.Patients and methods: The authors observed 49 patients (32 women, or 65.3Â %) aged 22 â€” 83 years (the median age of women was 46.1 Â± 1.3 years old, of men â€” 48.7 Â± 1.4 years old) with the rectal prolapse of varying severity. The Delormeâ€™s procedure was indicated for 28 patients (57.1Â %). Perianal proctosigmoidectomy (theÂ Altemeierâ€™s surgery) was performed in 12 patients (24.5Â %). In the young patients, preference was given to the Ripsteinâ€™s abdominal surgery (nine patients; 18.4Â %). To objectively assess the physical state of the anal sphincter apparatus, traditional sphincterometry was performed using S4402 sphincterometer with a nonperfusing sensor (Pro Medika GmbH, Germany), and the functional state of the sphincter complex was subjectively assessed using the Wexnerâ€™s score scale.Results: The best results were obtained after the Delormeâ€™s procedure (p<0.05), while the worse results were obtained in the young patients after the Ripsteinâ€™s surgery (p<0.05).Conclusion: The obtained results may be used for assessing the functional and physical state of the anal sphincter complex in the surgical treatment of the patients with the rectal prolapse syndrome, especially in those with ASFs of varying severity.
Risk scoring in predicting preterm birth of women receiving cervical cerclage
Authors: Fattah Chro Najmaddin
Published: November 2020

Background: Cervical incompetence is primarily a clinical diagnosis, which is characterized by recurrent painless dilation of cervix and spontaneous second trimester loss and preterm delivery. Despite recent advances, the indications and efficacy of cervical cerclage have been remained controversial. This study was performed with the aim of evaluating the risk factors of preterm birth among women who underwent cervical cerclage and establishing a scoring system to predict preterm labor in this group of women.Material and Methods: This retrospective cohort study was performed on 95 women who had undergone cervical cerclage from January 2016 to January 2018 in Maternity Teaching Hospital of Sulaimaniyah, Iraq. A total of 66 women who delivered after 34 weeks were used as control group, compared to 29 cases who delivered before 34 weeks.Results: According to the findings of the present study, there was a significant association between the preterm birth before the 34 weeks of pregnancy and the risk factors of pathological vaginal discharge, cervical length less than 25 mm prior to cerclage placement, and passive smoking. The positive predictive value was calculated using the prediction model was %99 with a risk score of 3, 47.6% with risk score 2 and 28.2 % with risk score 1.Conclusion: The prediction model can be used as a tool to identify patients at a higher risk for PTD <34 weeks and to recognize those that could benefit from cerclage and deliver after 34 weeks. It could also be a useful tool for identifying those high risk women with cerclage who require increased surveillance.
Pregnancy with seropositive toxoplasmosis: a case report
Authors: Darsana Natassa Zefanya , Kusuma Anak Agung Ngurah Jaya
Published: November 2020

Introduction: Toxoplasmosis is present in every country and seropositive rates vary between regions from less than 10% to more than 90%. Toxoplasmosis in pregnancy can result in severe sequelae to the fetus. Primary infection in pregnancy may cause spontaneous abortion or fetal death in utero. Congenital ocular and neurological abnormalities may also occur. We present a case involving toxoplasmosis infection in early pregnancy and an overview of the management and the clinical outcomes for both mother and fetus.Case report: A 26-year-old pregnant woman (G1P0A0) showed a high concentration of IgG anti-toxoplasmosis in early pregnancy with a concentration of 1200. Throughout the pregnancy, an increase in the concentration of IgG anti-toxoplasma was found. At 14 weeks gestation, concentration increased four-fold to 9068. During the ultrasound observation no hydrocephalus, ocular, and neurological abnormalities were found. Amniocentesis was performed for PCR examination and the result turned out negative. The patient was given spiramycin 1 gram daily for the remaining of her pregnancy. At 40 weeks gestation, the patient gave birth vaginally to a healthy term 3700 grams baby boy. There were no signs of major anomalies found in the baby.Conclusions: Diagnosis and screening of toxoplasmosis require proper understanding of serological examination, as well as the specificity and sensitivity of the diagnostic tools. Ultrasound monitoring for the detection of congenital toxoplasmosis can also help with diagnosis.
High c-reactive protein level as risk factors of complications in upper gastrointestinal bleeding
Authors: Mariadi I Ketut , Sudjana Karismayusa , Wibawa I Dewa Nyoman
Published: November 2020

Purpose: Upper gastrointestinal bleeding is the major medical emergency case in the field of gastroenterology. The complications of UGI bleeding are recurrent bleeding and death. Identifying risk factors for the complications is expected to prevent or reduce recurrent bleeding complications and deaths from UGI bleeding. This study aims to know the risk of UGI bleeding complications in patients with a high level of C reactive protein (CRP).Patients and methods: A prospective observational analytic study was performed, including all UGI bleeding patients (variceal and nonvariceal). CRP level was used to determine the high-risk cohort. High-risk cohort if the CRP level 5 mg/L and above, and low risk if CRP level less than 5 mg/L. The outcome of the study was the incidence of complication, both rebleeding and death during follow up for six weeks.Â Results: Based on the characteristic data of the sample, the high-risk group appears to have a slightly older age, higher leucocyte count, lower hemoglobin levels, and higher serum creatinine than the low-risk group. The incidence rate of complication in the high-risk group was 85.3% while in the low-risk group was 37.5%, and the relative risk (RR) was 2.27 (95% CI: 1.43-3.67). There were significant differences in the incidence of complications between the group, X2: 16; p <0.001. The RR for rebleeding in the high-risk to low-risk cohort was 2.68 (95% CI: 1.31-5.47); this difference is statistically significant (X2:9.3; p=0.02). The RR for death complication was 1.70 (95% CI: 0.63-4.53), and the difference is not statistically significant (X2: 1.2; p=0.28).Conclusion: In this study, we found the CRP level â‰¥ 5 mg/L as a significant risk factor for rebleeding complications but not mortality in a patient with UGI bleeding.
Delayed reconstruction of soft tissue defects in mangled lower extremities: A report of three cases
Authors: Hamid Agus Roy Rusly Hariantana , Sanjaya I Gusti Putu Hendra , Adnyana I Made Suka , Purwanthi I Gusti Ayu Putri , Ronge Grace Inriani , Samsarga Gede Wara
Published: November 2020

Background: The best timing for the soft tissue reconstruction procedure in the mangled lower extremity is still controversial. Despite the advantages of acute treatment, delayed soft tissue reconstruction are often inevitable for various reasons. This case report aims to present three cases of delayed reconstruction to treat lower extremities soft-tissue defects in mangled lower extremity following high-energy trauma.Case Series: This study included three cases that underwent delayed reconstruction for the mangled lower extremity. The definitive reconstructions were done in 15, 30, and 60 days after injury and all cases underwent serial debridement before the definitive procedure. The reconstruction methods used were skin graft and free flap. There was no graft/flap loss observed in this study.Conclusion: We believe that soft tissue reconstruction of mangled lower extremities following high-energy trauma may also be safely done in a delayed setting if the wound debridement is adequately done, and the basic reconstructive principles are fulfilled.
P2B2 PABI XVII Semarang 2020 Continuing Professional Development in Surgery: Increasing the Competence of General Surgeons to Improve The Health Services
Authors: Widjajanto Benedictus Kartika
Published: November 2020

Assalamuâ€™alaikum Wr. Wb. ShalomÂ Greetings, Praise Our gratitude to God Almighty because we are all in good health for His blessings and grace. We will hold P2B2 PABI XVII in 2020, and to coincide with that, we PABI Semarang Branch are entrusted with being the executor of this activity.PABI Semarang branch invited fellow surgeons to attend and participate in the P2B2 activities of PABI XVII, which we have prepared on 26-30 October 2020. The warmth of gathering with family also enlivened the event with the Family Program to explore the city of Semarang, which is famous for its Culinary Tour, Religious Tourism, Nature Tourism, Shopping Tour, and Cultural Heritage Tour.We will try to organize and provide the best. Let us welcome our fellow surgeons and their families.Wassalamu alaikum Wr. WbÂ Benedictus Kartika Widjajanto, MD chairman of the committee P2B2 PABI XVII Semarang 2020Â
Overexpression of nuclear factor kappa B (NF-ÐºB) protein as a risk factor for anthracyclin chemoresistance in luminal a subtype locally advanced breast cancer (LABC) at Sanglah General Hospital, Bali - Indonesia
Authors: Prabudi Prabudi , Manuaba Ida Bagus Tjakra Wibawa , Sudarsa I Wayan
Published: November 2020

Background: Around 68.6% of women who have breast cancer seek medical treatment at a locally advanced stage (LABC), where the neoadjuvant chemotherapy (NAC) modality is the initial choice therapy. Luminal A was recorded as the subtype with the chemotherapy response being the most resistant among others. The cause of chemoresistance is multi-factorial, and several studies correlate this condition with several anti-apoptotic agents expressed in the nucleus of cancer cells, especially nuclear factor-kappa B (NF-ÐºB). The NF-ÎºB transcription factor as an anti-apoptotic agent in some cancers blocks the apoptotic pathway through the extrinsic and intrinsic pathways. NF-ÎºB plays a vital role in the development of chemoresistance. Understanding the NF-ÎºB pathway and perceiving more about the cellular characteristics of LABC is very important to develop NF-ÎºB inhibitors as therapy. NF-ÎºB as a transcription factor can be considered a promising research target because it can affect oncogenes' transcription and play an essential role in prognostic and predictive biomarkers. This study was conducted to determine whether NF-ÎºB overexpression is a risk factor for anthracycline-based neoadjuvant chemoresistance in Luminal A subtype LABC patients at Sanglah General Hospital.Methods: An unpaired case-control study was conducted at Sanglah General Hospital. The research subjects were 40 people, divided into case groups (chemoresistance) and control groups (chemosensitive). Hereafter the NF-ÎºB H-Score was carried out by IHC examination. Data are presented in table form and analyzed by Chi-square test or Fischer exact.Results: Samples of cases with NF-ÎºB overexpression were obtained 13 (65%), compared with the control group 7 (35%) (p<0.05). Multivariate analysis has shown that NF-ÎºB overexpression is an independent factor against anthracycline-based chemotherapy resistance in advanced LABC patients with local luminal subtypes with p=0.013; OR 3.45 (95% CI=2.94-12.65).Conclusion: NF-ÎºB expression in Luminal A subtype LABC can be used as a predictor for anthracycline-based neoadjuvant chemoresistance. NF-ÎºB overexpression is a predictor factor for NAC chemoresistance in luminal A subtype LABC.
The 4th International Conference on Translational Medicine and Health Sciences
Authors: Arifin Muhamad Thohar
Published: November 2020

All praises to Allah, the most merciful, beneficent and compassionate, for His blessing that this conference could be organized today. I would like to express my greatest gratitude to Prof. Dr. Yos Johan Utama, S.H., M.Hum; Rector of Universitas Diponegoro, Dr. dr. Dwi Pudjonarko, M.Kes, Sp.S (K); Dean of Faculty of Medicine Universitas Diponegoro, Prof. Dr. Jamari, S.T., M.T.; Director of LPPM, Dr. dr. Hermina Sukmaningtyas, M.Kes., Sp.Rad and Dr. dr. Udadi Sadhana, M.Kes, Sp.PA, Vice Deans of Faculty of Medicine for all of their kind supervision during the preparation of this event. I would like to express my sincere gratitude to all of the committee members for all of your hard work, kind help, and best effort as a solid team work, by which this event can be held successfully even during the COVID-19 pandemics. I would like to thank all of the honorable speakers for your willingness to give lectures and all of participants from various institutions in the world. Welcome to the 4th International Conference on Translational Medicine and Health Sciences (ICTMHS) 2020.Â  It is a great pleasure to announce that this is the first virtual ICTMHS, which is traditionally held in Semarang, Indonesia. ICTMHS is an annual routine program that began in 2017 initiated by the faculty to support the university's vision of becoming a world class university. The theme of this conference is "Unraveling the New Normal Guideline Treatment of Diseases in COVID-19 Pandemic". This difficult time has pushed us to strengthen our collaborative practices in the health sectors including Interprofessional Education and Research, Collaborative Practice, Translational Medicine, and Nutrition, Dietetic and Food. This is an interesting theme that invites all health workers to unite to increase collaboration in various aspects to tackle the pandemics affecting our country and beyong. Through this conference, we hope to contribute in introducing and educating the scientific community on the recent advances in the medical, dentistry, nursing, pharmaceutical, and nutrition sciences field. As a major goal of this event, we hope that it can be an excellent chance to discuss interesting ideas and develop fruitful project in the future, network opportunities with old and new colleagues, coordination new partnerships which advance collaboration either about the research field or not, as well as the careers of all participants. Please enjoy your participation in ICTMHS 2020.Â Â Â dr. Muhamad Thohar Arifin, PhD, Sp.BS(K), PAChief of Organizing CommitteeÂ
Topical application of purple cabbage (Brassica oleracea L. var. capitata f. rubra) ethanol cream extract of dermic collagen on male Wistar rats (Rattus norvegicus) exposed to ultraviolet B
Authors: Triangga Apsari Komang Jegek , Dewi Ratnayanti I Gusti Ayu , Arijana I Gusti Komang Nyoman , Sugiritama I Wayan
Published: November 2020

Background: Purple cabbage or also known as red cabbage (Brassica oleracea L. var. capitata f. rubra) contains polyphenols, especially anthocyanin (cyanidin-3-diglucoside-5-glucoside). Anthocyanin has a protective effect against radical oxidative superoxide (ROS). Thus it can prevent skin damage caused by ultraviolet (UV)-B radiation.Aim: The research aims to prove the effectivity of distribution of purple cabbage ethanol cream extract prevented the decrease of dermal collagens on Wistar rats (Rattus norvegicus) exposed to UV-B rays.Method: This research was arranged with the randomize post-test only control group design. 30 rats were divided into 6 groups containing 5 rats each, there are control group (P1) without distribution of any cream, Treatment Group (P2) with a distribution of base cream (placebo), (P3) sunblock 33 SPF, (P4) 5%, (P5) 10 %, and (P6) 20 % smeared by purple cabbage ethanol cream extract. All groups exposed to UV-B with a total dose of 840 mJ/cm2 for 4 weeks. Then a sampling rats skin was done for examining the level of collagen skin with Sirius red staining. The level of collagen was calculated by the percentage of the area of the pixel of collagen and was compared with the pixels of entire dermal tissues.Result: The result demonstrated that the mean of collagens in The First Group/P1 (57.74%) and P2 (60.84%) decreased more significantly than P3 (82.17%), P4 (68.23%), P5 (76.93%), and P6 (84.54%) following UV-B exposure. The Post Hoc result showed that there was no significant difference in the level of collagen in the control group and placebo group and the sunblock group with the purple cabbageâ€™s ethanol cream extract group of 20% (p>0.05).Conclusion: the distribution of purple cabbage ethanol cream extract prevented the decrease of dermal collagens on male Wistar rats skin exposed to UV-B.
Clinicopathological patterns of cervical carcinoma in pathological anatomy laboratory at RSUP Sanglah Denpasar, Bali since 2012-2016
Authors: Subramaniam Shameni , Sumadi I Wayan Juli , Dewi I.G.A. Sri Mahendra
Published: November 2020

Background: Carcinoma of the cervix is the second most common cancer in women worldwide, Cervical cancer is the most common cancer in women in developing countries. Cervical cancer is the fourth most common cancer in women overall, with an estimated 528,000 new cases in 2012. According to the data clinicopathology of cervical cancer in Bali its still in a small amount.Aims: To obtain information about clinicopathology of cervical carcinoma from the year 2012 â€“ 2016.Methods: A descriptive design study is conducted to determine the clinical pathology profile of cervical carcinoma among patients in Sanglah Hospital, Denpasar, Bali in the year 2012 â€“ 2016. Medical records of the patients were used as the secondary data for this research. This research used the histopathologic document that available in Pathological Anatomy at RSUP Sanglah which mainly reports about patient condition starting from the early anamnesis period until the exact diagnosis of the patient which is due to the laboratory examination or other.Result and Conclusion: As of 2012 to 2016, there were 142 cases of cervical cancer patients in RSUP Sanglah.The age group of 41-50 years has the highest number of patients in the year 2012 â€“ 2016 which is about 52 patients. Abnormal vaginal bleeding is the most common clinical finding of cervical cancer patients from the year 2012- 2016 and carries 53% in 142 cases. It is found out that the most common histopathologic type of cervical cancer from the year 2012 â€“ 2016 is squamous cell followed by adenocarcinoma in the list.
Prevalence of anemia on chronic kidney disease and its influenced factors in Sanglah General Hospital 2015-2017, Bali
Authors: Gunaseelan Rubahshini , Surudarma I Wayan , Wihandani Desak Made , Sutadarma I Wayan Gede
Published: November 2020

Background: Anemia is the most common disease among chronic kidney disease (CKD) patients. Its prevalence increased gradually as kidney function decreased. Globally, it affects 1.62 billion people, which corresponds to 24.8% of the population.Aim: To determine the prevalence of anemia on CKD and its influenced factors at Sanglah Hospital, Bali.Method: This was a descriptive design study conducted in Sanglah General Hospital, Denpasar, Bali from 2015 until 2017. Medical records of the patients became the secondary data for this research.Result: From 2015 to 2017, there were 384 cases of CKD and 95 were anemic in the hospital. The prevalence of this case was 24.7 %. The age group of 51 - 60 years had the highest case. The males majorly dominated anemia on CKD. Anemia in stage V of CKD patients was the highest, and it increased more significant as the stages worsen, and diabetes was the leading underlying disease among anemia in CKD patients followed by CVD and glomerulonephritis. The hemoglobin level mean and glomerular filtration rate was lower than the normal one.
Level of awareness of alzheimerâ€™s disease among elderly people in Denpasar, Bali
Authors: Philip Sabrina Annamma , Wihandani Desak Made , Dewi Ni Nyoman Ayu
Published: November 2020

Background: Alzheimerâ€™s disease (AD) is a chronic, irreversible, progressive, neurodegenerative that slowly impair memory and thinking skills especially in elderly people. This study aims to determine the level of awareness of AD among elderly people in Denpasar, Bali.Methods: A descriptive cross-sectional study was conducted by using selfâ€“administered validated questionnaire to determine the level of awareness of Alzheimerâ€™s disease among the elderly people in Denpasar, Bali. The level of awareness could be classified into high awareness (>80%), moderate awareness (50-79%) and low awareness (<50%)Results: There were 50 subjects with 50 years old or above enrolled in this study. Most of the respondents had low awareness (82%) to the AD. About 38% of elderly people knew about AD and 58% of respondents said losing memory is a common thing in old age. Low education was said responsible increasing the risk of AD (30%). Only about 24% answered depression was prone to AD. In addition, about 34% said there was no cure for Alzheimerâ€™s disease.Conclusion: Level of awareness among elderly people towards Alzheimerâ€™s disease was low and needed improvement. Development and execution of educational programs should be carried out to the public to expand knowledge and understanding about Alzheimerâ€™s disease.
Drug prescription pattern of hypertension patients at primary healthcare facilities in West Denpasar
Authors: Silvaraju Kartiga , Artini I Gusti Ayu
Published: November 2020

Background: In the treatment of hypertension, investigating and monitoring the prescription patterns of antihypertensive medications time by time is essential to assess the adherence to treatment guidelines. Inappropriate prescribing negatively impacts on health and economy of individual and the society.Aim: The study aims to know the antihypertensive prescribing pattern of hypertension patients at primary healthcare facilities.Method: This studyis a descriptive study with cross sectional design as well as concern to the drug prescribing pattern of hypertension in both 1st and 2nd West Denpasar primary healthcare (PHC), Bali as many as 54 samples from January-December 2016.Result: Mean age is between 60-69 years old, and female were more prone to hypertension than male.Conclusion: The study revealed that the prescription of antihypertensive medication in West Denpasar primary healthcare was related to JNC guidelines, except monotherapy of diuretics.
Encapsulated liposome toward anthocyanin in Pectin-Based Dry Jelly as a management in pediatric obesity Management: a literature review
Authors: Mahardani Putu Nandika Tungga Yudanti , Kesumaputri Komang Diah Kurnia , Wiguna I Gede Wikania Wira , Wati Dyah Kanya
Published: November 2020

Background: In the globalization era, the high number of obesities is happened to the teenagers because of the unhealthy life-style. Obesity in the teenagers or pediatric obesity is important to be handled because it can trigger another complication that happened in the early age. This study aims to collect and analyze any source related to anthocyanin (ASN) from purple sweet potato (Ipomoea batatas L) as modality of obesity that is packaged as dry jelly.Methods: A literature search strategy was conducted to obtained eligible source of study such as books and journals from Google Scholar, Research Gate, and PubMed. The criteria of eligible literature used in this study were articles published on 1981-2019 from different type of study. About 73 literature were used as references regarding the potency of ASN from purple sweet potato (Ipomoea batatas L) as the modality for obese people.Results: ASN in the purple sweet potato has anti-obesity effect by decreasing the a-glucosidase enzyme and a-amylase, increasing glucagon-like-peptide-1 and peptide YY, changing the size of adipose cell, decreasing the lipogenic activity and inflammation, increasing the lipolysis and Î²-oxyanion adipose cell, as well as increasing the concentrate of brain-derived neutrophil factor in a brain. To increase the bioavailability of ASN, it has to be done the encapsulation with liposome base.Â  Modality is packaged in the dry jelly form with pectin base as a formulation in powder form taken orally. The modality consumption is 24 mg/kg of weight, however, after eating, the obese people tend to give the weight decreasing effect and cross section attractive to target modalities.Conclusion: According to the studies, the ASN from purple sweet potato and package in Pectin-Based Dry Jelly could be used as a novel strategy in managing the pediatric obesity.