bluuebunny/crossref_metadata_2025 huggingface dataset:
Predicting Tacrolimus Concentrations in the Skin of Adult Kidney Transplant Recipients: A Feasibility Study
Authors: Sartain Felicity , Viecelli Andrea K. , Veitch Margaret , Franklin Michael E. , Dymock Brian W. , Wells James W. , Campbell Scott B.
Published: January 2024

Solid organ transplant recipients are at an increased risk of developing skin cancers due to chronic immunosuppression, particularly with calcineurin inhibitors. Tacrolimus is the most prescribed calcineurin inhibitor in this patient cohort, and understanding tacrolimus concentrations in the skin will facilitate the development of anti-cancer preventive and therapeutic strategies. Here, we show that in mice, tacrolimus blood levels peaked rapidly ∼1 h post last oral dose while skin levels rose more slowly and remained high for at least 6 h. Subsequently, tacrolimus skin and blood concentrations were assessed in 15 kidney transplant recipients. The mean age was 61 years, the average time post-transplant was 7 years (range 0–21 years) and 87% were male. The average skin sampling time post tacrolimus dosing was 6 h 32 min. Skin tacrolimus concentrations ranged from 7.1 ng/g to 71.2 ng/g and correlated with blood concentrations (r = 0.6). Mouse and human mean skin concentrations were in a similar range. Our data suggests that tacrolimus measurements in the blood may be used to approximate tacrolimus concentrations in the skin of kidney transplant recipients, and further exploited for the delivery of anti-cancer therapies designed to antagonize the immunosuppressive effects of tacrolimus in the skin.
O potrzebie i kierunkach badania języka w filmie
Authors: Skowronek Bogusław
Published: January 2024

This article takes up the problem of studying language in film. It points to the significance of the issue and the causes of the film discourse having been ignored in analyses of Polish in the media to this date. It also indicates the primary parameters of the verbal aspect in a firm work, which can be subjected to a linguist overview. Additionally, it discusses the main linguistics methodologies that seem to be the most effective in examinations of film dialogues.
Analiza socjolektu warszawskich miłośników komunikacji miejskiej
Authors: Andrulonis Krzysztof
Published: January 2024

The aim of this article is to characterise the sociolect of Warsaw enthusiasts of urban transport, with a particular focus on lexis and phraseology. The author attempts a description of the group of people interested in mass transport as a communication community, analyses the formal characteristics of the sociolect they use, and presents the expressions used by them in an arrangement intended to reproduce the linguisƟtic worldview specifi c to them, which encompasses urban transport vehicles, vehicle equipment, service names, designations of places and people, as well as events involving urban transport.
A Discontinuous Galerkin–Finite Element Method for the Nonlinear Unsteady Burning Rate Responses of Solid Propellants
Authors: Wang Zhuopu , Yu Kairui , Liu Yuanzhe
Published: January 2024

The unsteady combustion of solid propellants under oscillating environments is the key to understanding the combustion instability inside solid rocket motors. The discontinuous Galerkin–finite element method (DG-FEM) is introduced to provide an efficient yet flexible numerical platform to investigate the combustion dynamics of solid propellants. The algorithm is developed for the classical unsteady model, the Zel’dovich–Novozhilov model. It is then validated based on a special analytical solution. The DG-FEM algorithm is then compared with the classical spectral method based on Laguerre polynomials. It is shown that the DG-FEM works more efficiently than the traditional spectral method, providing a more accurate solution with a lower computational cost.
Real-Time On-the-Fly Motion Planning for Urban Air Mobility via Updating Tree Data of Sampling-Based Algorithms Using Neural Network Inference
Authors: Lou Junlin , Yuksek Burak , Inalhan Gokhan , Tsourdos Antonios
Published: January 2024

In this study, we consider the problem of motion planning for urban air mobility applications to generate a minimal snap trajectory and trajectory that cost minimal time to reach a goal location in the presence of dynamic geo-fences and uncertainties in the urban airspace. We have developed two separate approaches for this problem because designing an algorithm individually for each objective yields better performance. The first approach that we propose is a decoupled method that includes designing a policy network based on a recurrent neural network for a reinforcement learning algorithm, and then combining an online trajectory generation algorithm to obtain the minimal snap trajectory for the vehicle. Additionally, in the second approach, we propose a coupled method using a generative adversarial imitation learning algorithm for training a recurrent-neural-network-based policy network and generating the time-optimized trajectory. The simulation results show that our approaches have a short computation time when compared to other algorithms with similar performance while guaranteeing sufficient exploration of the environment. In urban air mobility operations, our approaches are able to provide real-time on-the-fly motion re-planning for vehicles, and the re-planned trajectories maintain continuity for the executed trajectory. To the best of our knowledge, we propose one of the first approaches enabling one to perform an on-the-fly update of the final landing position and to optimize the path and trajectory in real-time while keeping explorations in the environment.
Delineation of Soil Management Zones and Validation through the Vigour of a Fodder Crop
Authors: Conceição Luís Alcino , Silva Luís , Valero Constantino , Loures Luís , Maçãs Benvindo
Published: January 2024

In Mediterranean farming systems, the semi-arid conditions and agricultural ecosystems have made site-specific management an important approach. This method aims to understand and handle the variability of soil properties and crop management, particularly through the utilization of geospatial information and accessible technology. Over three years in a 30 ha experimental field located in the Alentejo region (Portugal), crop establishment was monitored using data from soil apparent electrical conductivity (ECa), remote sensing (Sentinel-2), and in situ soil sampling. The procedure began with Step 1, involving the acquisition of soil spatial information and spatial interpolation. Subsequently, in Step 2, management zones (MZs) for soil characteristics were delineated using a combination of ECa measurements and soil analysis, and Step 3 spanned over three years of gathering meteorological data and crop remote sensing measurements. In Step 4, site-specific crop MZs were delineated by vegetation indexes (VIs). This article aims to increase the importance of in situ and remote assessments to more accurately identify areas with different productive potential. Results showed three MZs based on the percentage of sand, ECa, altimetry, exchangeable calcium, and exchangeable calcium properties, validated by crop VIs (Normalized Difference Vegetation Index (NDVI), Normalized Difference Red-Edge Index (NDRE), and Normalized Difference Moisture Index (NDMI)) over time. Although there are many sensorial techniques available for site-specific management, this paper emphasizes a methodology for the farmer to identify different MZs combining remote and in situ evaluations, supporting new opportunities for a more rational use of natural resources. Based on soil parameters, three site-specific management areas could be selected. NDMI was the index that best explained the MZs created according to soil properties.
Characteristics and Antimicrobial Activities of Iron Oxide Nanoparticles Obtained via Mixed-Mode Chemical/Biogenic Synthesis Using Spent Hop (Humulus lupulus L.) Extracts
Authors: Flieger Jolanta , Pasieczna-Patkowska Sylwia , Żuk Natalia , Panek Rafał , Korona-Głowniak Izabela , Suśniak Katarzyna , Pizoń Magdalena , Franus Wojciech
Published: January 2024

Iron oxide nanoparticles (IONPs) have many practical applications, ranging from environmental protection to biomedicine. IONPs are being investigated due to their high potential for antimicrobial activity and lack of toxicity to humans. However, the biological activity of IONPs is not uniform and depends on the synthesis conditions, which affect the shape, size and surface modification. The aim of this work is to synthesise IONPs using a mixed method, i.e., chemical co-precipitation combined with biogenic surface modification, using extracts from spent hops (Humulus lupulus L.) obtained as waste product from supercritical carbon dioxide hop extraction. Different extracts (water, dimethyl sulfoxide (DMSO), 80% ethanol, acetone, water) were further evaluated for antioxidant activity based on the silver nanoparticle antioxidant capacity (SNPAC), total phenolic content (TPC) and total flavonoid content (TFC). The IONPs were characterised via UV-vis spectroscopy, scanning electron microscopy (SEM), energy-dispersive spectrometry (EDS) and Fourier-transform infrared (FT-IR) spectroscopy. Spent hop extracts showed a high number of flavonoid compounds. The efficiency of the solvents used for the extraction can be classified as follows: DMSO > 80% ethanol > acetone > water. FT-IR/ATR spectra revealed the involvement of flavonoids such as xanthohumol and/or isoxanthohumol, bitter acids (i.e., humulones, lupulones) and proteins in the surface modification of the IONPs. SEM images showed a granular, spherical structure of the IONPs with diameters ranging from 81.16 to 142.5 nm. Surface modification with extracts generally weakened the activity of the IONPs against the tested Gram-positive and Gram-negative bacteria and yeasts by half. Only the modification of IONPs with DMSO extract improved their antibacterial properties against Gram-positive bacteria (Staphylococcus epidermidis, Staphylococcus aureus, Micrococcus luteus, Enterococcus faecalis, Bacillus cereus) from a MIC value of 2.5–10 mg/mL to 0.313–1.25 mg/mL.
Enhanced Antioxidative Capacity Transfer between Sow and Fetus via the Gut–Placenta Axis with Dietary Selenium Yeast and Glycerol Monolaurate Supplementation during Pregnancy
Authors: Zhang Jiawen , Wang Jun , Ma Ziwei , Fu Zhichao , Zhao Yueqi , Zeng Xiangfang , Lin Gang , Zhang Shihai , Guan Wutai , Chen Fang
Published: January 2024

This study aims to investigate the impact of dietary supplementation with selenium yeast (SeY) and glycerol monolaurate (GML) on the transfer of antioxidative capacity between the mother and fetus during pregnancy and its underlying mechanisms. A total of 160 sows with similar body weight and parity of 3–6 parity sows were randomly and uniformly allocated to four groups (n = 40) as follows: CON group, SeY group, GML group, and SG (SeY + GML) group. Animal feeding started from the 85th day of gestation and continued to the day of delivery. The supplementation of SeY and GML resulted in increased placental weight and reduced lipopolysaccharide (LPS) levels in sow plasma, placental tissues, and piglet plasma. Furthermore, the redox balance and inflammatory markers exhibited significant improvements in the plasma of sows fed with either SeY or GML, as well as in their offspring. Moreover, the addition of SeY and GML activated the Nrf2 signaling pathway, while downregulating the expression of pro-inflammatory genes and proteins associated with inflammatory pathways (MAPK and NF-κB). Vascular angiogenesis and nutrient transportation (amino acids, fatty acids, and glucose) were upregulated, whereas apoptosis signaling pathways within the placenta were downregulated with the supplementation of SeY and GML. The integrity of the intestinal and placental barriers significantly improved, as indicated by the increased expression of ZO-1, occludin, and claudin-1, along with reduced levels of DLA and DAO with dietary treatment. Moreover, supplementation of SeY and GML increased the abundance of Christensenellaceae_R-7_group, Clostridium_sensus_stricto_1, and Bacteroidota, while decreasing levels of gut microbiota metabolites LPS and trimethylamine N-oxide. Correlation analysis demonstrated a significant negative relationship between plasma LPS levels and placental weight, oxidative stress, and inflammation. In summary, dietary supplementation of SeY and GML enhanced the transfer of antioxidative capacity between maternal-fetal during pregnancy via gut–placenta axis through modulating sow microbiota composition.
A Method to Obtain the Transducers Impulse Response (TIR) in Photoacoustic Imaging
Authors: Yang Huan , Jing Xili , Yin Zhiyong , Chen Shuoyu , Wang Chun
Published: January 2024

Photoacoustic tomography (PAT) is an emerging imaging technique with great potential for a wide range of biomedical imaging applications. The transducers impulse response (TIR) is a key factor affecting the performance of photoacoustic imaging (PAI). It is customary in PAI to assume that TIR is known or obtain it from experiments. In this paper, we investigate the possibility of obtaining TIR in another way. A new method is proposed to extract TIR from observed optoacoustic signal (OPAS) data, without prior knowledge, as a known condition. It is based on the relation between the OPAS data and the photoacoustic pressure signal (PAPS) at transducer positions. The relation can be expressed as a homogeneous linear equation. The TIR is solved by solving the homogeneous equation. The numerical test verifies the effectiveness of the presented method. This article also discusses the effect of calculation parameters on the extracting precision of TIR.
Design and Control Simulation Analysis of Tender Tea Bud Picking Manipulator
Authors: Xue Peng , Li Qing , Fu Guodong
Published: January 2024

Aiming at the current complex problem of the mechanized high-quality picking of tender tea buds, this paper designs a tender tea bud-picking manipulator. In the picking process, the quality of the petiole and leaf blade of the tender tea bud is crucial, as the traditional cutting picking method destroys the cell structure of the tender tea buds, resulting in rapid oxidation of the cuts, thus losing the bright green appearance and pure taste. For this reason, this paper draws on the quality requirements of tender tea buds and traditional manual picking technology, simulating the process of the manual picking action, putting forward a ‘rotary pull-up’ clamping and ripping picking method, and designing the corresponding actuating structure. Using PVDF material piezoelectric thin-film sensors to detect the clamping force of the tender tea bud picking, the corresponding sensor hardware circuit is designed. In addition, the finite element analysis method is also used to carry out stress analysis on the mechanical fingers to verify the rationality of the automatic mechanism to ensure the high-quality picking of tender tea buds. In terms of the control of the manipulator, an SMC-PID control method is designed by using MATLAB/Simulink 2021 and Adam 2020 software for joint simulation. The way to control the closed-loop system angle and angular velocity error feedback is by adjusting the PID parameters, which quickly converts the sliding mode control to the sliding mode surface. The simulation results show that the SMC-PID control method proposed in this paper can meet the demand in tender tea bud picking and simultaneously has high control accuracy, response speed, and stability.
A Novel Continuous-Variable Quantum Key Distribution Scheme Based on Multi-Dimensional Multiplexing Technology
Authors: Zhang Shuai , Wang Heng , Pan Yan , Shao Yun , Zhang Tao , Huang Wei , Li Yang , Xu Bingjie
Published: January 2024

Dual-polarization division multiplexing (DPDM) is considered to be a potential method to boost the secure key rate (SKR) of the continuous-variable quantum key distribution (CV-QKD) system. In this article, we propose a pilot alternately assisted local local oscillator (LLO) CV-QKD scheme based on multi-dimensional multiplexing, where time division multiplexing and frequency division multiplexing are combined with dual-polarization multiplexing techniques to dramatically isolate the quantum signal from the pilot tone. We establish a general excess noise model for the LLO CV-QKD system to analyze the influence mechanism of various disturbances (e.g., time-domain diffusion, frequency-domain modulation residual, and polarization perturbation) on the key parameters, such as the channel transmittance and excess noise. Specifically, the photon leakage noise from the reference path to the quantum path and that between quantum signals with two different polarization paths are simultaneously analyzed in the dual-polarization LLO CV-QKD scheme for the first time. Furthermore, a series of simulations are established to verify the performance of the proposed scheme. The results show that the maximal isolation degree achieves 84.0 dB~90.4 dB, and the crosstalk between pilot tones and quantum signals can be suppressed to a very small range. By optimizing the system parameters (e.g., modulation variance and repetition frequency), the SKR with 12.801 Mbps@25 km is achieved under the infinite polarization extinction ratio (PER) and 30 dB residual ratio of the frequency modulation in the nanosecond-level pulse width. Moreover, the performance of the proposed DPDM CV-QKD scheme under relatively harsh conditions is simulated; the results show that the SKR with 1.02 Mbps@25 km is achieved under a relatively low PER of 17 dB with the nanosecond-level pulse width and 20 dB residual ratio of the frequency modulation. Our work lays an important theoretical foundation for the practical DPDM LLO CV-QKD system.
Editorial for Special Issue: Recent Advances in Space Debris
Authors: Olivieri Lorenzo , Makihara Kanjuro , Barilaro Leonardo
Published: January 2024

The near-Earth space debris environment represents an existing hazard for human activities in space [...]
Assessing Isometric Quadriceps and Hamstring Strength in Young Men and Women: Between-Session Reliability and Concurrent Validity
Authors: Mellemkjær Frederik H. , Madeleine Pascal , Nørgaard Jens E. , Jørgensen Martin G. , Kristiansen Mathias
Published: January 2024

This study assessed the between-session reliability of the FysioMeter H-station when measuring isometric quadriceps and hamstrings strength and H/Q (hamstring/quadriceps) ratio, and the concurrent validity when compared to an isokinetic dynamometer (ID). Sixteen young males and three females (25.6 ± 1.7 years old) performed maximum quadriceps and hamstring contractions using the H-station and the Humac NORM ID over two sessions. Between-session reliability was evaluated by comparing scores from the first and the second session. Concurrent validity was assessed by comparing scores from the H-station with the Humac NORM ID. The H-station showed excellent relative reliability for the quadriceps, hamstring, and the H/Q ratio with ICC2.1 ranging from 0.89 to 0.91. The relative reliability of the Humac NORM was good to moderate for the quadriceps, hamstring, and the H/Q ratio with ICC2.1 ranging from 0.89 to 0.91. Acceptable absolute reliability of the H-station was found across quadriceps, hamstring, and H/Q measures (coefficient of variance (CV) = 7.2 to 9.3%, limit of agreement (LOA) = 20.0 to 24.3%). The validity of the H-station was large for hamstring strength (r = 0.79) and moderate for quadriceps strength (r = 0.69) and H/Q ratio (r = 0.39) compared to the Humac NORM ID. Bland–Altman plots showed LOAs ranging from 37.9 to 59.5%. The results indicate that the H-station can be used to make reliable assessments of relative changes in maximum isometric quadriceps and hamstring strength.
Skull Vibration-Induced Nystagmus in Superior Semicircular Canal Dehiscence: A New Insight into Vestibular Exploration—A Review
Authors: Dumas Georges , Curthoys Ian , Castellucci Andrea , Dumas Laurent , Peultier-Celli Laetitia , Armato Enrico , Malara Pasquale , Perrin Philippe , Schmerber Sébastien
Published: January 2024

The third window syndrome, often associated with the Tullio phenomenon, is currently most often observed in patients with a superior semicircular-canal dehiscence (SCD) but is not specific to this pathology. Clinical and vestibular tests suggestive of this pathology are not always concomitantly observed and have been recently complemented by the skull-vibration-induced nystagmus test, which constitutes a bone-conducted Tullio phenomenon (BCTP). The aim of this work was to collect from the literature the insights given by this bedside test performed with bone-conducted stimulations in SCD. The PRISMA guidelines were used, and 10 publications were included and analyzed. Skull vibration-induced nystagmus (SVIN), as observed in 55 to 100% of SCD patients, usually signals SCD with greater sensitivity than the air-conducted Tullio phenomenon (ACTP) or the Hennebert sign. The SVIN direction when the test is performed on the vertex location at 100 Hz is most often ipsilaterally beating in 82% of cases for the horizontal and torsional components and down-beating for the vertical component. Vertex stimulations are more efficient than mastoid stimulations at 100 Hz but are equivalent at higher frequencies. SVIN efficiency may depend on stimulus location, order, and duration. In SCD, SVIN frequency sensitivity is extended toward high frequencies, with around 400 Hz being optimal. SVIN direction may depend in 25% on stimulus frequency and in 50% on stimulus location. Mastoid stimulations show frequently diverging results following the side of stimulation. An after-nystagmus observed in 25% of cases can be interpreted in light of recent physiological data showing two modes of activation: (1) cycle-by-cycle phase-locked activation of action potentials in SCC afferents with irregular resting discharge; (2) cupula deflection by fluid streaming caused by the travelling waves of fluid displacement initiated by sound or vibration at the point of the dehiscence. The SVIN direction and intensity may result from these two mechanisms’ competition. This instability explains the SVIN variability following stimulus location and frequency observed in some patients but also discrepancies between investigators. SVIN is a recent useful insight among other bedside examination tests for the diagnosis of SCD in clinical practice.
Spherical Graphite Anodes: Influence of Particle Size Distribution and Multilayer Structuring in Lithium-Ion Battery Cells
Authors: Gottschalk Laura , Müller Jannes , Schoo Alexander , Baasch Ernesto , Kwade Arno
Published: January 2024

Current research focuses on lithium-ion battery cells with a high energy density and efficient fast-charging capabilities. However, transport limitations, and, therefore, the uniform diffusion of lithium-ions across the electrode layers, remain a challenge and could lead to reduced cell performance. One approach to overcome these transport challenges is the use of subsequently produced two-layer anodes with the particle size variation of spherical graphite (x50 = 18 µm; x50 = 11 µm). Thereby, a defined pore network is created, which reduces the ionic resistance and ensuring improved fast charging capabilities. The analysis focuses on the evaluation of electrode properties and the electrochemical performance. By examining the pore size distribution of the anodes, it has been found that during the manufacturing of the two-layer anodes, carbon black and binder particles are transported into the existing microstructure of the lower layer, resulting in localized densification between the anode layers. This could also be supported by color measurements. This effect also extends to electrochemical investigations, with electrochemical impedance spectroscopy showing significantly lower ionic resistances in all two-layer anodes. Reduced ionic resistance and tortuosity near the separator due to absorption effects enhance the ion diffusion and have a direct impact on anode performance. Cell ageing analysis showed a significant capacity decrease of almost 15 mAh g −1 in the single-layer references only, in contrast to the stability of the two-layer anodes. This could also be attributed to the reduced ionic resistance and active counteraction of binder migration. In conclusion, this study highlights how subsequently produced two-layer anodes significantly shape the electrode properties and cell performance of lithium-ion batteries.
Lithium-Ion Supercapacitors and Batteries for Off-Grid PV Applications: Lifetime and Sizing
Authors: Ibrahim Tarek , Kerekes Tamas , Sera Dezso , Lashab Abderezak , Stroe Daniel-Ioan
Published: January 2024

The intermittent nature of power generation from photovoltaics (PV) requires reliable energy storage solutions. Using the storage system outdoors exposes it to variable temperatures, affecting both its storage capacity and lifespan. Utilizing and optimizing energy storage considering climatic variations and new storage technologies is still a research gap. Therefore, this paper presents a modified sizing algorithm based on the Golden Section Search method, aimed at optimizing the number of cells in an energy storage unit, with a specific focus on the unique conditions of Denmark. The considered energy storage solutions are Lithium-ion capacitors (LiCs) and Lithium-ion batteries (LiBs), which are tested under different temperatures and C-rates rates. The algorithm aims to maximize the number of autonomy cycles—defined as periods during which the system operates independently of the grid, marked by intervals between two consecutive 0% State of Charge (SoC) occurrences. Testing scenarios include dynamic temperature and dynamic load, constant temperature at 25 °C, and constant load, considering irradiation and temperature effects and cell capacity fading over a decade. A comparative analysis reveals that, on average, the LiC storage is sized at 70–80% of the LiB storage across various scenarios. Notably, under a constant-temperature scenario, the degradation rate accelerates, particularly for LiBs. By leveraging the modified Golden Section Search algorithm, this study provides an efficient approach to the sizing problem, optimizing the number of cells and thus offering a potential solution for energy storage in off-grid PV systems.
Comparison of Mechanical Behavior of Clear Aligner and Rapid Palatal Expander on Transverse Plane: An In Vitro Study
Authors: Bruni Alessandro , Abate Andrea , Maspero Cinzia , Castroflorio Tommaso
Published: January 2024

(1) Background: This study aims to investigate, within a controlled laboratory environment, the magnitude of the transversal load and the force decay over time produced by clear aligners in comparison to a Rapid Palatal Expander (RPE). (2) Methods: Resin models of a dental maxillary arch, additively manufactured from an intraoral scan, were inserted in a testing machine with uniaxial load cells to measure the force trend over time expressed by RPE and clear aligners. The mechanical load was recorded during a certain timeframe for both appliances. (3) Results: The force expressed by the RPE ranged from 30 to 50 N for each activation, decreasing with a nonlinear pattern over time. The force expressed by the clear aligner ranged from 3 to 5 N, decreasing with a linear pattern over time. In contrast, the force generated by the clear aligner fell within the range of 3 to 5 N, showing a linear reduction in force magnitude over the observed period of time. (4) Conclusions: The RPE exerted a force magnitude approximately ten times greater than that generated by clear aligners. Nevertheless, it is essential to acknowledge that the oral environment can significantly influence these results. These limitations underscore the need for caution when applying these findings to clinical settings.
Modeling the Synergistic Impact of Yttrium 90 Radioembolization and Immune Checkpoint Inhibitors on Hepatocellular Carcinoma
Authors: Kang Minah , Shin Yerim , Kim Yeseul , Ha Sangseok , Sung Wonmo
Published: January 2024

The impact of yttrium 90 radioembolization (Y90-RE) in combination with immune checkpoint inhibitors (ICIs) has recently gained attention. However, it is unclear how sequencing and dosage affect therapeutic efficacy. The purpose of this study was to develop a mathematical model to simulate the synergistic effects of Y90-RE and ICI combination therapy and find the optimal treatment sequences and dosages. We generated a hypothetical patient cohort and conducted simulations to apply different treatments to the same patient. The compartment of models is described with ordinary differential equations (ODEs), which represent targeted tumors, non-targeted tumors, and lymphocytes. We considered Y90-RE as a local treatment and ICIs as a systemic treatment. The model simulations show that Y90-RE and ICIs administered simultaneously yield greater benefits than subsequent sequential therapy. In addition, applying Y90-RE before ICIs has more benefits than applying ICIs before Y90-RE. Moreover, we also observed that the median PFS increased up to 31~36 months, and the DM rates at 3 years decreased up to 36~48% as the dosage of the two drugs increased (p < 0.05). The proposed model predicts a significant benefit of Y90-RE with ICIs from the results of the reduced irradiated tumor burden and the associated immune activation and suppression. Our model is expected to help optimize complex strategies and predict the efficacy of clinical trials for HCC patients.
Impact of In Ovo Leptin Injection and Dietary Protein Levels on Ovarian Growth Markers and Early Folliculogenesis in Post-Hatch Chicks (Gallus gallus domesticus)
Authors: Ahmadi Sadequllah , Nemoto Yuta , Ohkubo Takeshi
Published: January 2024

Genetically bred for rapid growth, broiler breeder hens develop obesity and ovarian dysfunction when fed ad libitum, resembling a condition that resembles human polycystic ovary syndrome (PCOS). Nutritional control applies to post-hatched chicks from one week onward to prevent the development of a PCOS-like phenotype in adult broilers. This study investigated the impact of a growth marker, leptin, and post-hatch nutritional intake on early-life ovarian function. Fertile broiler eggs were injected in ovo with physiological saline solution or 5 µg of leptin and then incubated. After hatching, female chicks were fed ad libitum a diet containing low protein (17% low crude protein (LP)) or standard protein (22% standard crude protein (SP)). Tissues were collected from 7- and 28-day-old chicks for RT-qPCR and histological analysis. In contrast to the LP diet, the SP diet suppressed the mRNA expression of ovarian growth markers essential for folliculogenesis in post-hatched chicks. Leptin injection did not influence ovarian growth markers but increased pituitary gonadotropin transcripts in 7-day-old chicks fed with LP diet. No treatment effects on follicle activation were noted on day 7, but by day 28, in ovo leptin-treated LP-fed chicks exhibited a higher percentage of primary follicles. These changes may have resulted from the early upregulation of genes by leptin during the first week, including pituitary gonadotropins and ovarian leptin receptors. The decline in ovarian growth markers with the SP diet highlights the importance of precise post-hatch protein calculation, which may influence future ovarian function in animals. These findings may contribute to future dietary strategies to enhance broiler reproduction.
Modern Polymers for Dental Application
Authors: Schierz Oliver
Published: January 2024

Ceramics dominate clinical procedures in modern dentistry related to the artificial replacement of teeth with fixed dental prostheses, replacing metal-based frameworks on a large scale [...]
Perioperative LiMAx Test Analysis: Impact of Portal Vein Embolisation, Chemotherapy and Major Liver Resection
Authors: Rühlmann Felix , Azizian Azadeh , Moosmann Christian , Bernhardt Markus , Keck Jan , Flebbe Hannah , Al-Bourini Omar , Hosseini Ali Seif Amir , Grade Marian , Lorf Thomas , Ghadimi Michael , Perl Thorsten , Gaedcke Jochen
Published: January 2024

Background: Postoperative liver failure (PLF) is a severe complication after major liver resection (MLR). To increase the safety of patients, clinical bedside tests are of great importance. However, limitations of their applicability and validity impair their value. Methods: Preoperative measurements of the liver maximum capacity (LiMAx) were performed in n = 40 patients, who underwent MLR (≥3 segments). Matched postoperative LiMAx was measured in n = 21 patients. Liver function was compared between pretreated patients (n = 11 with portal vein embolisation (PVE) and n = 19 patients with preoperative chemotherapy) and therapy naïve patients. The LiMAx values were compared with liver-specific blood parameters and volumetric analysis. Results: In total, n = 40 patients were enrolled in this study. The majority of patients (n = 33; 82.5%) had high preoperative LiMAx values (>315 µg/kg/h), while only seven patients (17.5%) had medium values (140–315 µg/kg/h), and none of the patients had low values (<140 µg/kg/h). A comparison of pretreated patients (with PVE and/or chemotherapy) and therapy naïve patients showed no significant difference in the preoperative LiMAx values (p > 0.05). The preoperative LiMAx values were significantly higher than the matched postoperative values on postoperative day 1 (p < 0.0001). A comparison between the expected and measured postoperative LiMAx showed a difference (≥10%) in 7 out of 13 patients (53.8%). After an initial postoperative decrease in the LiMAx, the patients without complications (n = 12) showed a continuous increase until 14 days after surgery. In the patients with postoperative complications, a decrease in the LiMAx was associated with a prolonged recovery. Conclusions: For patients undergoing MLR within the 0.5% rule, which is the clinical gold standard, the LiMAx values do not offer any additional information. Additionally, the LiMAx may have reflected liver function, but it did not deliver additional information regarding postoperative liver recovery. The clinical use of LiMAx might be relevant in selected patients beyond the 0.5% rule.
Bioinspire-Explore: Taxonomy-Driven Exploration of Biodiversity Data for Bioinspired Innovation
Authors: Saint-Sardos Adrien , Aish Annabelle , Tchakarov Nikolay , Bourgoin Thierry , Petit Luce-Marie , Sun Jian-Sheng , Vignes-Lebbe Régine
Published: January 2024

Successful bioinspired design depends on practitioners’ access to biological data in a relevant form. Although multiple open-access biodiversity databases exist, their presentation is often adapted to life scientists, rather than bioinspired designers. In this paper, we present a new tool, “Bioinspire-Explore”, for navigating biodiversity data in order to uncover biological systems of interest for a range of sectors. Bioinspire-Explore allows users to search for inspiring biological models via taxa (species, genera, etc.) as an entry point. It provides information on a taxon’s position in the “tree of life”, its distribution and climatic niche, as well as its appearance. Bioinspire-Explore also shows users connections in the bioinspiration literature between their taxon of interest and associated biological processes, habitats, and physical measurements by way of their semantic proximity. We believe Bioinspire-Explore has the potential to become an indispensable resource for both biologists and bioinspired designers in different fields.
Pufferfish Optimization Algorithm: A New Bio-Inspired Metaheuristic Algorithm for Solving Optimization Problems
Authors: Al-Baik Osama , Alomari Saleh , Alssayed Omar , Gochhait Saikat , Leonova Irina , Dutta Uma , Malik Om Parkash , Montazeri Zeinab , Dehghani Mohammad
Published: January 2024

A new bio-inspired metaheuristic algorithm named the Pufferfish Optimization Algorithm (POA), that imitates the natural behavior of pufferfish in nature, is introduced in this paper. The fundamental inspiration of POA is adapted from the defense mechanism of pufferfish against predators. In this defense mechanism, by filling its elastic stomach with water, the pufferfish becomes a spherical ball with pointed spines, and as a result, the hungry predator escapes from this threat. The POA theory is stated and then mathematically modeled in two phases: (i) exploration based on the simulation of a predator’s attack on a pufferfish and (ii) exploitation based on the simulation of a predator’s escape from spiny spherical pufferfish. The performance of POA is evaluated in handling the CEC 2017 test suite for problem dimensions equal to 10, 30, 50, and 100. The optimization results show that POA has achieved an effective solution with the appropriate ability in exploration, exploitation, and the balance between them during the search process. The quality of POA in the optimization process is compared with the performance of twelve well-known metaheuristic algorithms. The simulation results show that POA provides superior performance by achieving better results in most of the benchmark functions in order to solve the CEC 2017 test suite compared to competitor algorithms. Also, the effectiveness of POA to handle optimization tasks in real-world applications is evaluated on twenty-two constrained optimization problems from the CEC 2011 test suite and four engineering design problems. Simulation results show that POA provides effective performance in handling real-world applications by achieving better solutions compared to competitor algorithms.
Marine Predator Algorithm-Based Optimal PI Controllers for LVRT Capability Enhancement of Grid-Connected PV Systems
Authors: Ellithy Hazem Hassan , Hasanien Hany M. , Alharbi Mohammed , Sobhy Mohamed A. , Taha Adel M. , Attia Mahmoud A.
Published: January 2024

Photovoltaic (PV) systems are becoming essential to our energy landscape as renewable energy sources become more widely integrated into power networks. Preserving grid stability, especially during voltage sags, is one of the significant difficulties confronting the implementation of these technologies. This attribute is referred to as low-voltage ride-through (LVRT). To overcome this issue, adopting a Proportional-Integral (PI) controller, a control system standard, is proving to be an efficient solution. This paper provides a unique algorithm-based approach of the Marine Predator Algorithm (MPA) for optimized tuning of the used PI controller, mainly focusing on inverter control, to improve the LVRT of the grid, leading to improvements in the overshoot, undershoot, settling time, and steady-state response of the system. The fitness function is optimized using the MPA to determine the settings of the PI controller. This process helps to optimally design the controllers optimally, thus improving the inverter control and performance and enhancing the system’s LVRT capability. The methodology is tested in case of a 3L-G fault. To test its validity, the proposed approach is compared with rival standard optimization-based PI controllers, namely Grey Wolf Optimization and Particle Swarm Optimization. The comparison shows that the used algorithm provides better results with a higher convergence rate with overshoot ranging from 14% to 40% less in the case of DC-Link Voltage and active power and also settling times in the case of MPA being less than PSO and GWO by 0.76 to 0.95 s.
Nano/Micro Biosensors for Biomedical Applications
Authors: Lee Jin-Ho , Kim Ki Su
Published: January 2024

Advances in nano/micro technologies in recent years have significantly improved biosensors in terms of their viability for biomedical purposes, from diagnostic to therapeutic applications, allowing for effective early detection and personalized treatment modalities [...]
Single-Sided Deafness and Hearing Rehabilitation Modalities: Contralateral Routing of Signal Devices, Bone Conduction Devices, and Cochlear Implants
Authors: Pantaleo Alessandra , Murri Alessandra , Cavallaro Giada , Pontillo Vito , Auricchio Debora , Quaranta Nicola
Published: January 2024

Single sided deafness (SSD) is characterized by significant sensorineural hearing loss, severe or profound, in only one ear. SSD adversely affects various aspects of auditory perception, including causing impairment in sound localization, difficulties with speech comprehension in noisy environments, and decreased spatial awareness, resulting in a significant decline in overall quality of life (QoL). Several treatment options are available for SSD, including cochlear implants (CI), contralateral routing of signal (CROS), and bone conduction devices (BCD). The lack of consensus on outcome domains and measurement tools complicates treatment comparisons and decision-making. This narrative overview aims to summarize the treatment options available for SSD in adult and pediatric populations, discussing their respective advantages and disadvantages. Rerouting devices (CROS and BCD) attenuate the effects of head shadow and improve sound awareness and signal-to-noise ratio in the affected ear; however, they cannot restore binaural hearing. CROS devices, being non-implantable, are the least invasive option. Cochlear implantation is the only strategy that can restore binaural hearing, delivering significant improvements in speech perception, spatial localization, tinnitus control, and overall QoL. Comprehensive preoperative counseling, including a discussion of alternative technologies, implications of no treatment, expectations, and auditory training, is critical to optimizing therapeutic outcomes.
Familiarity Is Key: Exploring the Effect of Familiarity on the Face-Voice Correlation
Authors: Stevenage Sarah V. , Edey Rebecca , Keay Rebecca , Morrison Rebecca , Robertson David J.
Published: January 2024

Recent research has examined the extent to which face and voice processing are associated by virtue of the fact that both tap into a common person perception system. However, existing findings do not yet fully clarify the role of familiarity in this association. Given this, two experiments are presented that examine face-voice correlations for unfamiliar stimuli (Experiment 1) and for familiar stimuli (Experiment 2). With care being taken to use tasks that avoid floor and ceiling effects and that use realistic speech-based voice clips, the results suggested a significant positive but small-sized correlation between face and voice processing when recognizing unfamiliar individuals. In contrast, the correlation when matching familiar individuals was significant and positive, but much larger. The results supported the existing literature suggesting that face and voice processing are aligned as constituents of an overarching person perception system. However, the difference in magnitude of their association here reinforced the view that familiar and unfamiliar stimuli are processed in different ways. This likely reflects the importance of a pre-existing mental representation and cross-talk within the neural architectures when processing familiar faces and voices, and yet the reliance on more superficial stimulus-based and modality-specific analysis when processing unfamiliar faces and voices.
Effects of Targeted Memory Reactivation on Cortical Networks
Authors: Santamaria Lorena , Koopman Anne C. M. , Bekinschtein Tristan , Lewis Penelope
Published: January 2024

Sleep is a complex physiological process with an important role in memory consolidation characterised by a series of spatiotemporal changes in brain activity and connectivity. Here, we investigate how task-related responses differ between pre-sleep wake, sleep, and post-sleep wake. To this end, we trained participants on a serial reaction time task using both right and left hands using Targeted Memory Reactivation (TMR), in which auditory cues are associated with learned material and then re-presented in subsequent wake or sleep periods in order to elicit memory reactivation. The neural responses just after each cue showed increased theta band connectivity between frontal and other cortical regions, as well as between hemispheres, in slow wave sleep compared to pre- or post-sleep wake. This pattern was consistent across the cues associated with both right- and left-handed movements. We also searched for hand-specific connectivity and found that this could be identified in within-hemisphere connectivity after TMR cues during sleep and post-sleep sessions. The fact that we could identify which hand had been cued during sleep suggests that these connectivity measures could potentially be used to determine how successfully memory is reactivated by our manipulation. Collectively, these findings indicate that TMR modulates the brain cortical networks showing clear differences between wake and sleep connectivity patterns.
Unveiling Economic Synchrony: Analyzing Lag Dynamics between GDP Growth and Construction Activity in Poland and Other EU Countries
Authors: Sobieraj Janusz , Metelski Dominik
Published: January 2024

This study examines the dynamic relationship between the business cycle and the construction sector activity in 27 EU countries, focusing on Poland. Using the cross-correlation function (CCF) and a set of economic- and construction-related variables, including GDP growth, construction production, building permits, and construction operating time by backlog, quarterly data from 2000Q1 to 2023Q2 (94 quarters in total) are analyzed. Beyond the CCF analysis, causality is also examined using Toda–Yamamoto tests to explore the nuanced temporal relationships between GDP growth and construction activity proxies. The research uncovers synchronized positive lag max results for construction production, suggesting a harmonized response to broader economic changes, especially within 9 to 11 quarters. In contrast, building permits and construction time by backlog show divergent positive lag max values, suggesting the need for tailored, localized strategies. Negative lag max values emphasize the anticipatory role of the construction sector as an early indicator of economic change. Overcoming methodological challenges, this study provides insights critical for policymakers and researchers, promoting a nuanced understanding of economic synchrony and guiding informed strategies for sustainable development. Future recommendations include refining localized strategies based on lag patterns for optimal economic management.
Experimental Study on the Properties and Hydration Mechanism of Gypsum-Based Composite Cementitious Materials
Authors: Liu Jianping , Song Ge , Ge Xiaowei , Liu Bing , Liu Kaixin , Tian Yulin , Wang Xu , Hu Zhihang
Published: January 2024

In order to achieve the resourceful, large-scale and high-value utilization of bulk industrial solid wastes such as flue gas desulfurization gypsum (FGDG), fly ash (FA) and ground blast furnace slag (GGBS), and to reduce the dosage of cementitious materials, orthogonal experimental methods were used to prepare composite cementitious materials based on the principle of synergistic coupling and reconstruction of multi-solid wastes. Through the method of extreme difference and ANOVA, the influence law of different factor levels on the performance of the cementitious materials was studied, and the maximum compressive strength of cementitious materials was reached when the ordinary Portland cement (OPC) dosage was 20%, the FGDG dosage was 56%, the FA dosage was 19.2% and the slag dosage was 4.8%, and the W/B was 0.55. The hydration products and microscopic morphology of the cementitious materials were analyzed by means of XRD, SEM and MIP techniques, so as to elucidate the complex synergistic hydration mechanism, and then to determine the more optimal group distribution ratio. The results show that the hydration reaction between FGDG and OPC can be synergistic with each other, and C-A-H further generates AFt under the action of SO42−, and at the same time, it plays the role of alkali-salt joint excitation for FA–GGBS, generates a large amount of cementitious materials, fills up the pores of the gypsum crystal structure, and forms a dense microstructure.