bluuebunny/crossref_metadata_2025 huggingface dataset:
CHD1L Regulates Cell Survival in Breast Cancer and Its Inhibition by OTI-611 Impedes the DNA Damage Response and Induces PARthanatos
Authors: Sala Rita , Esquer Hector , Kellett Timothy , Kearns Jeffrey T. , Awolade Paul , Zhou Qiong , LaBarbera Daniel V.
Published: August 2024

The Chromodomain helicase DNA-binding protein 1-like (CHD1L) is a nucleosome remodeling enzyme, which plays a key role in chromatin relaxation during the DNA damage response. Genome editing has shown that deletion of CHD1L sensitizes cells to PARPi, but the effect of its pharmacological inhibition has not been defined. Triple-negative breast cancer SUM149PT, HCC1937, and MDA-MB-231 cells were used to assess the mechanism of action of the CHD1Li OTI-611. Cytotoxicity as a single agent or in combination with standard-of-care treatments was assessed in tumor organoids. Immunofluorescence was used to assess the translocation of PAR and AIF to the cytoplasm or the nucleus and to study markers of DNA damage or apoptosis. Trapping of PARP1/2 or CHD1L onto chromatin was also assessed by in situ subcellular fractionation and immunofluorescence and validated by Western blot. We show that the inhibition of CHD1L’s ATPase activity by OTI-611 is cytotoxic to triple-negative breast cancer tumor organoids and synergizes with PARPi and chemotherapy independently of the BRCA mutation status. The inhibition of the remodeling function blocks the phosphorylation of H2AX, traps CHD1L on chromatin, and leaves PAR chains on PARP1/2 open for hydrolysis. PAR hydrolysis traps PARP1/2 at DNA damage sites and mediates PAR translocation to the cytoplasm, release of AIF from the mitochondria, and induction of PARthanatos. The targeted inhibition of CHD1L’s oncogenic function by OTI-611 signifies an innovative therapeutic strategy for breast cancer and other cancers. This approach capitalizes on CHD1L-mediated DNA repair and cell survival vulnerabilities, thereby creating synergy with standard-of-care therapies
Epigenetics, Microbiome and Personalized Medicine: Focus on Kidney Disease
Authors: Gigliotti Giuseppe , Joshi Rashmi , Khalid Anam , Widmer David , Boccellino Mariarosaria , Viggiano Davide
Published: August 2024

Personalized medicine, which involves modifying treatment strategies/drug dosages based on massive laboratory/imaging data, faces large statistical and study design problems. The authors believe that the use of continuous multidimensional data, such as those regarding gut microbiota, or binary multidimensional systems properly transformed into a continuous variable, such as the epigenetic clock, offer an advantageous scenario for the design of trials of personalized medicine. We will discuss examples focusing on kidney diseases, specifically on IgA nephropathy. While gut dysbiosis can provide a treatment strategy to restore the standard gut microbiota using probiotics, transforming epigenetic omics data into epigenetic clocks offers a promising tool for personalized acute and chronic kidney disease care. Epigenetic clocks involve a complex transformation of DNA methylome data into estimated biological age. These clocks can identify people at high risk of developing kidney problems even before symptoms appear. Some of the effects of both the epigenetic clock and microbiota on kidney diseases seem to be mediated by endothelial dysfunction. These “big data” (epigenetic clocks and microbiota) can help tailor treatment plans by pinpointing patients likely to experience rapid declines or those who might not need overly aggressive therapies.
Machine Learning for Breast Cancer Detection with Dual-Port Textile UWB MIMO Bra-Tenna System
Authors: Elnaggar Azza H. , El-Hameed Anwer S. Abd , Yakout Mohamed A. , Areed Nihal F. F.
Published: August 2024

A wearable textile bra-tenna system based on dual-polarization sensors for breast cancer (BC) detection is presented in this paper. The core concept behind our work is to investigate which type of polarization is most effective for BC detection, using the combination of orthogonal polarization signals with machine learning (ML) techniques to enhance detection accuracy. The bra-tenna sensors have a bandwidth ranging from 2–12 GHz. To complement the proposed system, detection based on machine learning algorithms (MLAs) is developed and tested to enhance its functionality. Using scattered signals at different polarizations, the bra-tenna system uses MLAs to predict BC in its early stages. Classification techniques are highly effective for data classification, especially in the biomedical field. Two scenarios are considered: Scenario 1, where the system detects a tumor or non-tumor, and Scenario 2, where the system detects three classes of one, two, and non-tumors. This confirms that MLAs can detect tumors as small as 10 mm. ML techniques, including eight algorithms such as the Support Vector Machine (SVM), Random Forest (RF), Gradient Boosting Methods (GBMs), Decision Tree (DT) classifier, Ada Boost (AD), CatBoost, Extreme Gradient Boosting (XG Boost), and Logistic Regression (LR), are applied to this balanced dataset. For optimal analysis of the BC, a performance evaluation is performed. Notably, SVM achieves outstanding performance in both scenarios, with metrics such as its F1 score, recall, accuracy, receiver operating characteristic (ROC) curve, area under the ROC curve (AUC), and precision all exceeding 90%, helping doctors to effectively investigate BC. Furthermore, the Horizontal-Horizontal (HH) sensor configuration achieved the highest accuracy of 98% and 99% for SVMs in the two scenarios, respectively.
Operational Planning and Design Considerations for Underground Logistics Transportation in Texas
Authors: Najafi Mohammad , Kaushal Vinayak , Visser Johan
Published: August 2024

The logistics transportation system is critical to the United States economy. Underground Logistics Transportation (ULT) is a class of automated transportation systems in which vehicles carry freight through pipelines and tunnels between terminals. Being able to use a part of the underground space of existing highways will greatly facilitate the construction of such pipelines and tunnels and reduce their construction costs. Underground Logistics Transportation (ULT) could be the answer to make freight transport more sustainable and competitive. Texas highways and railroads are expected to increase by nearly 207% from 2003 to 2030. Truck tonnage will grow by 251%, while rail tonnage is forecasted to increase 118%. The number of trucks carrying NAFTA goods will increase by 263%, and the number of rail units will grow by 195%. This will have a profound impact on the highway and rail systems. The objective of this paper is to present requirements and operational components for three types of ULT lines: standard shipping containers, a standard crate size, and a standard pallet size. This study examines the use of ULT as a mode of underground transportation with the help of three case studies. This research shows that ULT is financially viable, feasible, greener, cost effective, and can become an important part of intermodal freight mobility.
Temperature-Dependent Oviposition Models for Monochamus saltuarius (Coleoptera: Cerambycidae)
Authors: Lee Hyoseok , Jung Jong-Kook , Nam Youngwoo , Koh Sang-Hyun
Published: August 2024

Monochamus saltuarius Gebler is a serious insect pest in Europe and East Asia regions, including Portugal, Spain, China, Japan, and Korea. It transfers the pine wood nematode Bursaphelenchus xylophilus to conifer trees, resulting in pine wilt disease (PWD). As temperature is a key factor influencing insect population dynamics, temperature-dependent models describing M. saltuarius oviposition could estimate population growth potential and evaluate outbreak risks. In this study, the longevity and fecundity of M. saltuarius females were measured under constant temperature conditions ranging from 20 to 32 °C, and temperature-dependent models were constructed. The longevity of M. saltuarius females ranged from 83.36 days to 22.92 days, with a total fecundity of 141 eggs and 52.77 eggs at 20 °C and 32 °C, respectively. To describe oviposition, we used a single-phase simulation describing oviposition as a single model and a two-phase simulation describing sexual maturation and oviposition as two separate models. These models effectively described M. saltuarius oviposition (r2 > 0.96) under constant temperature conditions, with the two-phase simulation demonstrating greater accuracy overall. Such models could facilitate assessments of PWD risks. The modeling framework of this study shows potential for predicting threats from various forestry and agricultural pests.
Prevalence of Diamine Oxidase Enzyme (DAO) Deficiency in Subjects with Insomnia-Related Symptoms
Authors: López García Raquel , Ferrer-Garcia Júlia , Sansalvador Anna , Quera-Salva Maria-Antonia
Published: August 2024

Background: To assess the prevalence of diamine oxidase (DAO) enzyme deficiency caused by single nucleotide polymorphisms (SNPs) of the AOC1 gene in a sample of patients with symptoms of insomnia. Methods: A total of 167 adult patients (>18 years of age) with symptoms of insomnia attended a specialized institute for healthy sleep, in Barcelona (Spain), between May and November 2023, and underwent genotyping analysis of the four most relevant SNP variants, including c.691G>7 (rs2052129), c.47C>T (rs10156191), c.995C>T (rs1049742), and c.1990C>G (rs1049793). Results: Genetic DAO deficiency was present in 138 patients, with a prevalence rate of 82.6% (95% CI 76–88.1%). Difficulties in staying asleep were the most common complaints in 88% of patients followed by trouble falling asleep in 60.5%. More than half of patients suffered from insomnia symptoms every day. Also, 99.4% reported daytime consequences of insomnia, with fatigue (79.6%), mood changes (72.5%), and impaired concentration in 70.1%. When patients were grouped by DAO-score, which reflected the number of heterozygous and homozygous SNPs variants, the group with a DAO-score ≥ 4 vs. 1 showed higher percentages of insomnia-related symptoms, in particular, trouble staying asleep and early morning awakening. These two symptoms were also more common in the presence of the c.1990C>G (rs1049793) variant. Conclusions: This preliminary real-world study presents novel evidence of a potential link between a DAO enzyme deficiency of a genetic origin and clinical symptoms of insomnia, which may suggest the potential benefit of DAO supplementation to improve the quality of sleep in these subjects. The study was registered at ClinicalTrials.gov (NCT06488027).
Prenatal Manifestation of Transient Abnormal Myelopoiesis: Case Report and Review of the Literature
Authors: Walasik Izabela , Litwińska-Korcz Ewelina , Szpotańska Monika , Stanirowski Paweł , Księżopolska Aleksandra , Ludwin Artur , Litwińska Magdalena
Published: August 2024

Background: Congenital malignancies are unusual fetal conditions, and therefore, the data on their prenatal manifestation are limited. Transient abnormal myelopoiesis (TAM) is a hematologic disorder characteristic for babies with trisomy 21 and based on the transient appearance of blast cells in peripheral blood. Methods: This paper presents prenatal manifestation of congenital TAM in a newborn with normal karyotype and reviews the literature on prenatal manifestation of this disorder. Results: A pregnant woman in her third pregnancy referred herself to the hospital for reduced fetal movements at 30 weeks of gestation. Admission’s ultrasound scan showed an increased middle cerebral artery peak systolic velocity together with hepatomegaly. The patient was admitted to the labor ward for cardiotocography monitoring which showed acute fetal distress with repeated unprovoked decelerations. An emergency cesarean section was conducted and a phenotypically normal female newborn with low Apgar score was delivered. Further examination of the peripheral blood revealed anemia and leukocytosis with high blast proportion. A bone marrow aspirate revealed 70.2% of blasts in a sample with an abnormal karyotype of 47 XX+21. Cytogenetic analysis of the blasts with later microarray comparative genomic hybridization confirmed the presence of GATA1 mutation. However, the buccal smear showed a normal karyotype in the infant. The disease was classified as TAM. Conclusions: Our study demonstrates a rare case of prenatal manifestation of TAM in a neonate with a normal karyotype. Obstetricians should pay attention to symptoms like high MCA PSV and hepatosplenomegaly as possible causes of fetal hematological disorders and differentiate it with infection or isoimmunization.
Investigating Combination Therapy: The Role of Lutetium-177 PSMA-617 Radioligand Therapy and Androgen Receptor Pathway Inhibitors in Metastatic Castration-Resistant Prostate Cancer
Authors: Kınıkoğlu Oğuzcan , Öven Bala Başak , Çelik Serkan , Alan Selçuk Nalan , Beydağı Gamze , Akçay Kaan , Kabasakal Levent
Published: August 2024

Background: The combination of Lutetium-177 (Lu-177) PSMA-617 radioligand therapy (RLT) with androgen receptor pathway inhibitors (ARPIs) has shown promise in metastatic castration-resistant prostate cancer (mCRPC). However, real-world data on the efficacy and safety of this combination are limited. This study aimed to evaluate the impact of combination therapy with Lu-177 PSMA-617 RLT and ARPIs on progression-free survival (PFS) and overall survival (OS) in patients with mCRPC. Methods: In this retrospective study, 104 mCRPC patients receiving Lu-177 PSMA-617 RLT at our institution between December 2017 and January 2024 were divided into the following two groups those receiving Lu-177 PSMA-617 RLT plus ARPI (n = 34) and those receiving Lu-177 PSMA-617 RLT alone (n = 70). Patients received 150 to 200 millicuries Lu-177 PSMA-617 RLT in each cycle. PFS and zOS were assessed using Kaplan–Meier analysis and Cox proportional hazard models. Results: The combination therapy significantly prolonged median PFS compared to Lu-177 PSMA-617 RLT alone (11 vs. 5.6 months; HR, 0.47; 95% CI, 0.28–0.79; p < 0.01). A trend towards improved OS was also observed in the combination group (20.3 vs. 15.9 months; HR, 0.58; 95% CI, 0.33–1.02; p = 0.06). Age was a significant predictor of OS (21.2 vs. 12.4 months for younger vs. older patients; p < 0.01), while Gleason score and visceral involvement did not significantly impact PFS. The safety profile indicated that adverse effects were generally comparable between the two groups, with no statistically significant differences in the incidence of anemia, neutropenia, thrombocytopenia, nephrotoxicity, or hepatotoxicity. Conclusions: This study provides evidence that combining Lu-177 PSMA-617 RLT with ARPIs may significantly improve PFS in mCRPC patients. The potential OS benefit warrants further investigation in larger prospective trials. Age should be considered when making treatment decisions for mCRPC patients.
Mechanical Circulatory Support with Impella: Principles, Evidence, and Daily Practice
Authors: Masiero Giulia , Arturi Federico , Panza Andrea , Tarantini Giuseppe
Published: August 2024

The Impella (Abiomed, Danvers, MA, USA) microaxial pump is a percutaneous mechanical circulatory support (MCS) that has been shown to increase coronary perfusion, reduce myocardial oxygen demand, and improve peripheral organ perfusion. Therefore, indications for the Impella device include emergency use for cardiogenic shock (CS) and pre-emptive implantation during high-risk percutaneous coronary intervention (HR-PCI). However, despite their exponential use in cardiovascular practice over the past decade, there is limited randomized evidence to support the benefits of this therapy and growing concern regarding complication rates. In this review, we summarize the principles, evidence, and practical considerations of the most widely used Impella CP percutaneous left ventricular support in both CS and HR-PCI settings, moving from the historical background to current issues and future expectations for this device.
Osteoporosis as the Female-Specific Risk Factor for Dynapenia in Elderly Patients with Type 2 Diabetes
Authors: Lu Chieh-Hua , Su Sheng-Chiang , Kuo Feng-Chih
Published: August 2024

Aims: Dynapenia is a noteworthy health issue contributing to increased risk of falling, but its co-occurrence with osteoporosis in elderly individuals with type 2 diabetes mellitus (T2DM) has not been well explored. Therefore, this study aimed to establish the association between osteoporosis and dynapenia, focusing on T2DM females due to their high prevalence of osteoporosis and fragility. Methods: We conducted a cross-sectional study to recruit a total of 103 T2DM patients (43 males and 60 females), aged between 50 and 80 years with median 68.0 years. Dual-energy X-ray absorptiometry (DXA) and dominant hand grip strength measurements were performed to define body composition, osteoporosis, and dynapenia in a sex-specific manner. Results: Higher prevalence of dynapenia and dyna-osteoporosis was observed in female T2DM patients with a significantly positive correlation between osteoporosis and dynapenia even after adjustment of body mass index (BMI). By performing a multivariate logistic regression analysis, both BMI and osteoporosis were identified as risk predictors for the development of dynapenia in female T2DM patients with odds ratios (95% CIs) of 1.234 (1.029–1.480) and 4.883 (1.352–17.630), respectively. Conclusions: Our results point out there is high, female-specific co-occurrence of osteoporosis and dynapenia in T2DM patients. Moreover, having osteoporosis and increased BMI might boost the risk of dynapenia in elderly females with T2DM.
Bone Imaging of the Knee Using Short-Interval Delta Ultrashort Echo Time and Field Echo Imaging
Authors: Bae Won C. , Malis Vadim , Yamashita Yuichi , Mesa Anya , Vucevic Diana , Miyazaki Mitsue
Published: August 2024

Background: Computed tomography (CT) is the preferred imaging modality for bone evaluation of the knee, while MRI of the bone is actively being developed. We present three techniques using short-interval delta ultrashort echo time (δUTE), field echo (FE), and FE with high resolution–deep learning reconstruction (HR–DLR) for direct bone MRI. Methods: Knees of healthy volunteers (n = 5, 3 females, 38 ± 17.2 years old) were imaged. CT-like images were generated by averaging images from multiple echoes and inverting. The bone signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were determined. Results: The δUTE depicted a cortical bone with high signal intensity but could not resolve trabeculae. In contrast, both the FE and FE HR–DLR images depicted cortical and trabecular bone with high signal. Quantitatively, while δUTE had a good bone SNR of ~100 and CNR of ~40 for the cortical bone, the SNR for the FE HR–DLR was significantly higher (p < 0.05), at over 400, and CNR at over 200. Conclusions: For 3D rendering of the bone surfaces, the δUTE provided better image contrast and separation of bone from ligaments and tendons than the FE sequences. While there still is no MRI technique that provides a perfect CT-like contrast, continued advancement of MRI techniques may provide benefits for specific use cases.
Functional Outcome after Direct Anterior Approach Total Hip Arthroplasty (DAA-THA) for Coxa Profunda and Protrusio Acetabuli—A Retrospective Study
Authors: Heinz Tizian , Vasilev Hristo , Anderson Philip Mark , Stratos Ioannis , Jakuscheit Axel , Horas Konstantin , Holzapfel Boris Michael , Rudert Maximilian , Weißenberger Manuel
Published: August 2024

Objective: The direct anterior approach (DAA) is a recognized technique for total hip arthroplasty (THA) that spares soft tissue. Functional and clinical outcomes following THA via the DAA in patients with complex acetabular deformities, specifically coxa profunda (CP) and protrusio acetabuli (PA), have yet to be determined. Methods: A retrospective analysis was conducted on 188 primary THA cases, including 100 CP hips and 88 PA hips, performed via the DAA. Functional and clinical outcomes were evaluated by means of the Western Ontario and McMaster Universities Arthritis Index (WOMAC) and Harris Hip Score (HHS) preoperatively and at a mean follow-up of 46 ± 14 months. Furthermore, potential complications were assessed. Results: From the preoperative to the latest postoperative visit, a significant improvement in the WOMAC total score was observed (CP: −34.89 ± 20.66; PA: −40.38 ± 21.11). The length of stay (LOS) was the only parameter predictive of the postoperative WOMAC total score, with each day of LOS increasing the postoperative WOMAC by a mean of 1.77 points (p < 0.01). The HHS improved by 38.37 ± 14.23 (PA-group) and 32.79 ± 14.89 points (CP-group). No significant difference in the patient-reported outcome measures (PROMs) between the CP- and PA-group was found. The survival rate for any revision was 97.70% (PA-group) and 92.80% (CP-group). Conclusion: The results of this study indicate that the minimally invasive DAA was not predictive of the functional and clinical outcome following DAA-THA in patients with CP and PA. Improvements in the mean WOMAC and HHS scores were above or within the reported MCID. Additionally, revision rates were well below those reported in the literature for short and intermediate follow-up periods.
Treatment Trends and Epidemiologic Changes in Acetabular Fracture Management over the Course of 10 Years: An Analysis Based on 2853 Patients as Treated by the German Pelvic Multicenter Study Group
Authors: Wittenberg Silvan , Rau Daniel , Paraskevaidis Melissa , Jaecker Vera , Stöckle Ulrich , Märdian Sven
Published: August 2024

Background/Objectives: Acetabular fractures, traditionally linked to high-impact trauma in younger adults, are increasingly observed in the elderly due to falls and poor bone quality. This demographic shift necessitates updated treatment approaches. This study analyzes demographic trends and treatment evolution over a decade using the German pelvic fracture registry. Methods: Data on acetabular fractures were analyzed from the German pelvic fracture registry of the German Trauma Society. Parameters included classification, demographics, treatment methods, and surgical details. Trends were assessed by grouping patients based on treatment intervals and age, comparing treatment methods, surgical approaches, and reduction quality across these groups, considering fracture types and treatment volume. Results: The study included 2853 unilateral acetabular fractures with a mean patient age of 61.5 years, showing an increasing age trend. A shift from simple to complex fractures involving the anterior acetabular column was observed. Operative treatment was performed in 62.5% of cases, more common in non-geriatric patients and those with posterior column involvement. The use of anterior intrapelvic approaches increased over time, replacing the Ilioinguinal extrapelvic approach. Anatomical reduction was achieved in 47.4% of cases, with 31.7% having imperfect reductions and 20.9% poor reductions. High-volume centers had significantly better reduction outcomes, particularly for simple fractures. Geriatric patients exhibited worse reduction quality compared to younger patients. In-hospital mortality was stable at 3.3%. Conclusions: The study highlights a demographic shift towards an older patient population, leading to more complex fracture patterns. Despite advancements in surgical techniques and new implant technologies, these demographic changes have resulted in lower reduction quality for complex fractures. Emphasis is placed on careful patient selection for reconstructive surgery or endoprosthetic replacement to ensure high-quality outcomes.
Surgical Navigation and CAD-CAM-Designed PEEK Prosthesis for the Surgical Treatment of Facial Intraosseous Vascular Anomalies
Authors: Dean Alicia , Estévez Orlando , Centella Concepción , Sanjuan-Sanjuan Alba , Sánchez-Frías Marina E. , Alamillos Francisco J.
Published: August 2024

Background: Intraosseous vascular anomalies in the facial skeleton present significant diagnostic and therapeutic challenges due to complex anatomy. These anomalies represent about 0.5–1% of bony neoplastic and tumor-like lesions, usually presenting as a firm, painless mass. Most described intraosseous vascular malformations are venous malformations (VMs) and, more rarely, arteriovenous malformations. Objectives: The objectives of this work are to show our experience, protocol and the applications of computer planning, virtual surgery, CAD-CAM design, surgical navigation, and computer-assisted navigated piezoelectric surgery in the treatment of facial intraosseous vascular anomalies and to evaluate the advantages and disadvantages. Methods: Three females and one male with periorbital intraosseous vascular anomalies were treated using en-block resection and immediate reconstruction with a custom-made PEEK prosthesis. One lesion was in the supraorbital rim and orbital roof, one in the frontal bone and orbital roof, and two in the zygomatic region. We accomplished the resection and reconstruction of the lesion using virtual planning, CAD-CAM design, surgical navigation and piezoelectric device navigation. Results: There were no complications related to the surgery assisted with navigation. With an accuracy of less than 1 mm, the procedure may be carried out in accordance with the surgical plan. The surgeon’s degree of uncertainty during deep osteotomies and in locations with low visibility was decreased by the use of the navigated piezoelectric device. Conclusions: Resection and reconstruction of facial intraosseous vascular anomalies benefit from this new surgical strategy using CAD-CAM technologies, computer-assisted navigated piezoelectric surgery, and surgical navigation.
Editorial for the Special Issue on Carbon Fiber Composites, Volume II
Authors: Zhu Jiadeng
Published: August 2024

Fibers with lengths much larger than their widths have been developed over centuries because of their unique properties [...]
Experimental Study on the Spring-like Effect on the Hydrodynamic Performance of an Oscillating Water Column Wave Energy Converter
Authors: Yuan Ning , Xu Chuanli , Liu Zhen
Published: August 2024

The oscillating water column (OWC) wave energy converter has demonstrated significant potential for converting ocean wave energy. The spring-like effect of air compressibility can significantly affect the hydrodynamic behavior of the device, but it has rarely been investigated through experimental studies. In this study, an experimental test on a model-scaled OWC device was carried out in a wave flume using a series of regular and irregular waves. The spring-like effect was taken into account by the combination of the air chamber with an additional air reservoir of appropriate volume, where the total volume was scaled according to the square of the Froude scale. The hydrodynamic performance was compared with the results obtained without considering the spring-like effect. A phase difference between the air pressure and airflow rate was observed when employing the additional air reservoir. The amplitudes of free surface elevation and airflow rate increased, while the air pressure was reduced when the spring-like effect was considered. The results demonstrate that failure to consider the spring-like effect can lead to overestimation of the hydrodynamic efficiencies, and the errors were mainly affected by the incident wave frequency.
A Data-Driven DNN Model to Predict the Ultimate Strength of a Ship’s Bottom Structure
Authors: Ban Im-jun , Lim Chaeog , Kim Gi-yong , Choi Seo-young , Shin Sung-chul
Published: August 2024

Plates and curved plates are essential components in ship construction. In the design stage, the methods used to evaluate the ultimate strength required to confirm the structural safety of plates include prediction through analytical methods, finite-element analysis (FEA), and empirical formulas. However, with nonlinear buckling, the results of the empirical formula and the FEA differ for small flank angles (1~9). As a result, the prediction of the nonlinear ultimate strength of flank angle (1~9) plates still requires significant computation time and cost. To compensate for this, this study performed an ultimate strength prediction method utilizing a deep neural network together with the 4050 curved plate analysis. In addition, this paper presents the analysis results of the nonlinear finite-element method and the geometric shape and ratio of curved plates as training data. Based on the results of this study, designers can more efficiently design appropriate curved plate members by considering the ultimate strength.
Consensus Control of Heterogeneous Uncertain Multiple Autonomous Underwater Vehicle Recovery Systems in Scenarios of Implicit Reduced Visibility
Authors: Li Zixuan , Zhang Wei , Wu Wenhua , Shi Yefan
Published: August 2024

This paper investigates consensus control in heterogeneous and uncertain multiple autonomous underwater vehicle (AUV) systems under implicit reduced visibility conditions. We address challenges such as environmental uncertainties and system nonlinearity by utilizing a unified connectivity approach to model low-visibility interactions and heterogeneous multi-AUV dynamics. Our main contributions include developing a feedback linearization model for heterogeneous multi-AUV systems that accounts for uncertainties, introducing an adaptive consensus controller based on relative positioning that effectively manages implicit visual interaction limitations and validating our strategies through stability analysis and numerical simulations. Our simulations demonstrate approximately a 60% improvement in accuracy compared to previous algorithms, highlighting the practical value of our approach in AUV recovery operations. These advancements provide a robust solution for consensus control in complex underwater environments.
Detecting Gaps in Knowledge: The Case of the Anisakis in Northwestern Spain
Authors: Garcia-Sanchez Beatriz , Masiá Paula , Garcia-Vazquez Eva , Ardura Alba , Dopico Eduardo
Published: August 2024

In the marine environment, fish parasites are present in most seafood species. The most common are nematodes of the genus Anisakis, which can parasitize human tissues, causing anisakiasis and allergies—in some cases with a strong reaction, such as anaphylactic shock. This happens when people ingest live or dead larvae present in the muscles or viscera of a wide range of fish and cephalopods. Consumer education has been positioned as one of the most effective alternatives for its prevention. This study, carried out in Asturias (northwest Spain), sought to identify the seafood products that present the greatest risk of anisakiasis for consumers, taking into account their consumption, the prevalence of Anisakis, and consumer knowledge about this parasitosis. In the results, hake (Merluccius merluccius) and cod (Gadus morhua), frequently consumed in the region and with high parasite prevalence, do not pose a great risk because they are consumed when well cooked. Instead, sardine (Sardina pilchardus), highly consumed and less parasitized, and anchovy (Engraulis encrasicolus), highly parasitized and less consumed, would exhibit a medium risk. Young participants know more about the risks of anisakiasis from raw seafood. The gaps detected in the knowledge about the ability of temperature treatments to eliminate parasites, especially in allergic people, must be addressed for better prevention. We suggest campaigns adapted to the population sectors.
Feeding Habits of Scomber japonicus Inferred by Stable Isotope and Fatty Acid Analyses
Authors: Chen Yingcong , Hu Guanyu , Zhao Zhenfang , Chen Xinjun , Liu Bilin
Published: August 2024

Scomber japonicus is widely distributed off the coast of Japan and in the northwestern Pacific. It is an important target for fisheries. To reveal the differences in diet shifts and niche changes of S. japonicus, we collected samples in the high seas of the northwest Pacific (38°59′ N–43°00′ N, 150°30′ E–161°48′ E) from June to August 2021. We utilized stable isotope and fatty acid analyses to study the differences in body length and sex of S. japonicus. The results showed no significant differences in stable isotope values and fatty acid composition between male and female individuals (p > 0.05). Differences in δ13C and δ15N values among different body length groups were also not significant (p > 0.05). Both δ13C and δ15N values showed a trend of increasing and then decreasing across different body length groups. The niche width of S. japonicus in different body length groups first increased and then decreased, with niche overlap among the groups exceeding 60%. Principal component analysis (PCA) results showed that the main fatty acids in S. japonicus were C14:0, C16:0, C18:0, C16:1n-7, C18:1n-9, C18:3n-6, C20:5n-3, C20:4n-6 and 22:6n-3. Except for C18:0 and C20:4n-6, the content of the other fatty acids showed significant differences among different body length groups (p < 0.05). The results of the similarity analysis (ANOSIM) indicated that the fatty acid compositions of the 100–130 mm length group were significantly different from those of the 131–160 mm and 161–190 mm length groups (p < 0.05). However, there were no significant differences among the other size groups (p > 0.05). During the growth and development of S. japonicus, the proportion of krill in their diet gradually decreased. Meanwhile, their consumption of zooplankton, diatoms and fish significantly increased. Additionally, S. japonicus also consumed crustaceans, but their intakes of planktonic bacteria and green algae were relatively low. We suggested that there were no significant differences between male and female individuals of S. japonicus. As they grew and developed, the ecological niche and feeding habits of S. japonicus continuously changed.
Research on Hydrodynamics of Trans-Media Vehicles Considering Underwater Time-Varying Attitudes
Authors: Liu Shuo , Du Chihao , Han Yijie , Zhang Yu , Lin Wanglin , Cai Yong , Wang Tao
Published: August 2024

A trans-media vehicle is a new type of equipment that can adapt to two environments, water and air, to maintain optimal hydrodynamic and aerodynamic performance. However, no matter what kind of trans-media vehicle, its dynamics are much more complicated when traversing the interface of the medium, as the parameters are time-varying due to the change in ambient medium and vehicle attitudes. In order to improve the stability and performance of the trans-media vehicle in complex environments, an accurate mathematical model is established to characterize the dynamics of the trans-media vehicle in this process in this study. The time-varying hydrodynamic coefficients with different attitudes or depths are obtained using computational fluid dynamics software. The mathematical model is solved iteratively using a Runge–Kutta solver to calculate the dynamic response. A prototype of trans-media vehicle is fabricated, and motion experiments are performed in the pool. The experimental results confirm the effectiveness of the established model and lay the foundation for further controller design, providing a reference for the dynamic modeling of other similar equipment operating in complex environments. The primary novelty of this study lies in the fact that the established dynamic model considers the complex interaction between the attitude of the trans-media vehicle and the inherent different properties of water and air and utilizes computational fluid dynamics software to accurately obtain time-varying coefficients under different attitudes and depths. This approach not only recognizes the criticality of orientation-dependent hydrodynamic coefficients but also incorporates their temporal variations, which were often overlooked in previous studies.
Integrative Analysis of Multi-Omics Data to Identify Deregulated Molecular Pathways and Druggable Targets in Chronic Lymphocytic Leukemia
Authors: Mavridou Dimitra , Psatha Konstantina , Aivaliotis Michalis
Published: August 2024

Chronic Lymphocytic Leukemia (CLL) is the most common B-cell malignancy in the Western world, characterized by frequent relapses despite temporary remissions. Our study integrated publicly available proteomic, transcriptomic, and patient survival datasets to identify key differences between healthy and CLL samples. We exposed approximately 1000 proteins that differentiate healthy from cancerous cells, with 608 upregulated and 415 downregulated in CLL cases. Notable upregulated proteins include YEATS2 (an epigenetic regulator), PIGR (Polymeric immunoglobulin receptor), and SNRPA (a splicing factor), which may serve as prognostic biomarkers for this disease. Key pathways implicated in CLL progression involve RNA processing, stress resistance, and immune response deficits. Furthermore, we identified three existing drugs—Bosutinib, Vorinostat, and Panobinostat—for potential further investigation in drug repurposing in CLL. We also found limited correlation between transcriptomic and proteomic data, emphasizing the importance of proteomics in understanding gene expression regulation mechanisms. This generally known disparity highlights once again that mRNA levels do not accurately predict protein abundance due to many regulatory factors, such as protein degradation, post-transcriptional modifications, and differing rates of translation. These results demonstrate the value of integrating omics data to uncover deregulated proteins and pathways in cancer and suggest new therapeutic avenues for CLL.
Propelling Nurse-Led Structured Intervention to Enhance Self-Care among Patients with Chronic Heart Failure (PROACT-HF): A Cluster Randomized Controlled Trial Study Protocol
Authors: Okazaki Momoko , Suzuki Takahiro , Mizuno Atsushi , Ikegame Toshimi , Ito Noriki , Onoda Mai , Miyawaki Ikuko , Moriyama Yuka , Yabuki Taku , Yamada Satomi , Yoneoka Daisuke , Iwasawa Yuko , Tagami Kyoko , Yoshikawa Kumiko
Published: August 2024

Background: Heart Failure (HF) is a common chronic disease that has a high readmission rate and is associated with worsening symptoms and major financial impacts. Disease management implemented during or after an HF hospitalization has been shown to reduce hospitalization and mortality rates. Particularly for outpatients, it is necessary to provide self-care interventions. Structured nurse-led support such as timely follow-ups, including phone calls, is beneficial for improving self-care assessments. Evidence for nurse-led support has been investigated but is less than conclusive. The aim of this study is to compare the effectiveness of a nurse-led structured intervention for outpatients with chronic HF against the usual medical care in terms of self-care behaviors and occurrence of symptom exacerbation or rehospitalization. Methods and analysis: This is a cluster-randomized controlled trial. A total of 40 facilities with certified HF nurses will be allocated to two-arm clusters at a 1:1 ratio, randomly to the intervention or usual care arms. A total of 210 participants will be assigned from the hospital. Participants will be adults aged 18 years or older diagnosed with chronic HF who are classified as Stage C according to the ACCF/AHA Heart Failure staging system. In the intervention group, patients will receive structured nursing support. This begins with weekly support, including phone calls, for the first month, then transitions to monthly support thereafter. The aim is to ensure the stability of their living conditions, promote medication adherence, and encourage self-management. In the control group, patients will receive the usual care. Primary outcomes will assess the improvement or continuation of self-care behavior as measured by changes in EHFScBS (European Heart Failure Self-Care Behavior Scale) scores. Secondary outcomes include occurrence of readmission within 30 days, 3 months, 6 months, and 1 year after discharge, duration of home care until readmission, and blood levels of BNP and NT-proBNP.
Comparing Optical Coherence Tomography Angiography Metrics in Healthy Chinese and Caucasian Adults
Authors: Bujor Inna , Chua Jacqueline , Tan Bingyao , Iancu Raluca , Pirvulescu Ruxandra , Geamanu Aida , Bostan Mihai , Toma Eduard , Ionescu Diana , Schmetterer Leopold , Popa-Cherecheanu Alina
Published: August 2024

Background: The goal of the present study was to identify differences in retinal microvasculature between healthy Caucasians and healthy Asians in order to provide a better understanding of the variability between different ethnic groups. Methods: In this cross-sectional study, 191 healthy Chinese and Caucasian participants were enrolled. They underwent optical coherence tomography angiography (OCTA) scans with Zeiss Cirrus HD-5000 Spectral-Domain with AngioPlex. Linear regression models were used to investigate the association of OCTA metrics with potential risk factors. Results: Whereas participants in both groups are comparable in age and sex, Chinese participants had a longer axial length, higher spherical equivalent, higher intraocular pressure (p < 0.001), and a significantly higher perfusion density of large vessels in the superficial capillary plexus (p < 0.001). Regarding the foveolar avascular area (FAZ), Chinese participants had a larger superficial FAZ, a wider superficial FAZ perimeter, and a more circular deep FAZ shape (p < 0.001). Conclusions: There are significant differences in the retinal vasculature between Caucasian and Asian eyes as measured using OCTA. This needs to be considered when developing normative databases. Whether such findings relate to inter-racial differences in the incidence of retinal vascular disease remains to be shown.
A Cyborg Walk for Urban Analysis? From Existing Walking Methodologies to the Integration of Machine Learning
Authors: Valenzuela-Levi Nicolás , Gálvez Ramírez Nicolás , Nilo Cristóbal , Ponce-Méndez Javiera , Kristjanpoller Werner , Zúñiga Marcos , Torres Nicolás
Published: August 2024

Although walking methodologies (WMs) and machine learning (ML) have been objects of interest for urban scholars, it is difficult to find research that integrates both. We propose a ‘cyborg walk’ method and apply it to studying litter in public spaces. Walking routes are created based on an unsupervised learning algorithm (k-means) to classify public spaces. Then, a deep learning model (YOLOv5) is used to collect data from geotagged photos taken by an automatic Insta360 X3 camera worn by human walkers. Results from image recognition have an accuracy between 83.7% and 95%, which is similar to what is validated by the literature. The data collected by the machine are automatically georeferenced thanks to the metadata generated by a GPS attached to the camera. WMs could benefit from the introduction of ML for informative route optimisation and georeferenced visual data quantification. The links between these findings and the existing WM literature are discussed, reflecting on the parallels between this ‘cyborg walk’ experiment and the seminal cyborg metaphor proposed by Donna Haraway.
Effects of Conservation Tillage on Agricultural Green Total Factor Productivity in Black Soil Region: Evidence from Heilongjiang Province, China
Authors: Zhang Mei , Zhang Hanye , Deng Yun , Yi Chuanqi
Published: August 2024

The implementation of conservation tillage is crucial for the preservation and utilization of black soil. This study examined 297 new agricultural management entities in five pilot counties in the black soil region of northeast China. Using the SBM-Undesirable model, this study measured and evaluated the agricultural green total factor productivity (AGTFP) of these entities. We further employed the Tobit model to explore the impact of conservation tillage on the AGTFP. The findings revealed that the average AGTFP value of the sample entities was 0.4364, indicating a generally low degree of AGTFP that exhibited significant variation. Improvement in input indicators (such as machinery) and undesirable output indicators (such as net carbon emissions) was particularly needed. Additionally, conservation tillage had a significant positive impact on AGTFP, with a higher number of applied technologies correlating with increased productivity. Material subsidies for conservation tillage offered greater direct cost relief and had a stronger positive effect on AGTFP in comparison with cash subsidies. Furthermore, apart from policy factors, key production and operation characteristics—such as access to agricultural materials—also significantly influenced AGTFP. The results of this study offer a valuable decision-making framework and scientific reference for countries in black soil regions worldwide, enabling them to enhance the conservation and sustainable utilization of this vital resource.
Urban Green Infrastructure Connectivity: The Role of Private Semi-Natural Areas
Authors: Jamil Raihan , Julian Jason P. , Jensen Jennifer L. R. , Meitzen Kimberly M.
Published: August 2024

Green spaces and blue spaces in cities provide a wealth of benefits to the urban social–ecological system. Unfortunately, urban development fragments natural habitats, reducing connectivity and biodiversity. Urban green–blue infrastructure (UGI) networks can mitigate these effects by providing ecological corridors that enhance habitat connectivity. This study examined UGI connectivity for two indicator species in a rapidly developing city in the southern United States. We mapped and analyzed UGI at a high resolution (0.6 m) across the entire city, with a focus on semi-natural areas in private land and residential neighborhoods. Integrating graph theory and a gravity model, we assessed structural UGI networks and ranked them based on their ability to support functional connectivity. Most of the potential habitat corridors we mapped in this project traversed private lands, including 58% of the priority habitat for the Golden-cheeked Warbler and 69% of the priority habitat for the Rio Grande Wild Turkey. Riparian zones and other areas with dense tree cover were critical linkages in these habitat corridors. Our findings illustrate the important role that private semi-natural areas play in UGI, habitat connectivity, and essential ecosystem services.
Habitat and Body Condition of Small Mammals in a Country at Mid-Latitude
Authors: Balčiauskas Linas , Balčiauskienė Laima
Published: August 2024

The relationship between the body condition of different small mammal species and the habitat they occupy is poorly analyzed. We analyzed the body condition index, BCI, of 18 small mammal species trapped in forest, shrub, wetland, meadow, riparian, mixed and fragmented, disturbed, agricultural, and commensal habitats of Lithuania during the span of 1980–2023. The composition of small mammal communities was habitat-dependent, being richest in meadows, with eighteen species, and poorest in riparian habitats, with nine species. A significant variation in the BCI with respect to habitat was observed in eight small mammal species (Sorex araneus, S. minutus, Apodemus agrarius, A. flavicollis, Clethrionomys glareolus, Alexandromys oeconomus, Microtus agrestis, and M. arvalis). The highest average BCI for most of these species was found in disturbed habitats, with S. minutus and M. arvalis showing the highest BCI in agricultural habitats. The lowest average BCI for most species was found in mixed habitats, while C. glareolus and M. arvalis exhibited the lowest BCI in shrub habitats. In general, species dominating certain habitats did not have the highest BCI. This is the first multi-species, multi-habitat study of body condition in small mammals at mid-latitudes.