bluuebunny/crossref_metadata_2025 huggingface dataset:
Ogilvie syndrome following spinal surgery
Authors: Pedroza-Pinheiro Romulo , Nascimento-Ribeiro Leonardo , Tavares Costa , Aparecido Defino
Published: February 2022

Objective: Ogilvie syndrome is a rare disease characterized by acute abdominal pain and distention in the absence of mechanical obstruction. It is a rare condition that usually affects hospitalized patients in association with severe illness or after surgery. A few cases have been reported after spinal surgery. Material and Methods: Retrospective reports of Ogilvie syndrome in three patients that underwent spinal surgery (two posterior lumbar instrumented fusion and one anterior cervical fusion). Surgical treatment was required in two patients and conservative treatment in one out the three patients. Results: Two patients had a complete recovery of symptoms and signs of the disease, and one died. Conclusion: Ogilvie syndrome is rare, but it should be considered a differential diagnosis in patients who have undergone surgery and present with significant abdominal pain and distention. Level of evidence II; Retrospective study.
Activity of Samuel Ferjenčík (1793–1855) in the Cultural-historic Context
Authors:   Institute of Slovak Literature, Slovak Academy of Sciences, Braxatoris Martin , Braxatorisová Anita ,   University of Ss. Cyril and Methodius in Trnava
Published: February 2022

The authors analyze the life, activities and views of an unfairly forgotten person in Slovak cultural history: Samuel Ferjenčík, priest, writer, publicist, meteorologist, pomologist, friend of J. Kollar and acquaintance of I.V. Goethe. The article examines his personality in the aspect of the contemporary cultural context. The authors’ attention is also focused on the controversial aspects of his life, namely on his participation in the dispute about the Štúr›s variant of the literary Slovak language, on his speech against the manifesto of J.M. Hurban “Brothers Slovaks” and on his activities during the Slovak National Uprising of 1848–1849. The authors strive for a fair assessment of his views, taking into account the value diversity of the contemporary cultural elite and generational specifics.
Ventana al paisaje cultural: Una propuesta de conservación y restauración paisajística del atrio del conjunto religioso San Francisco de Asís en Atizapán de Zaragoza, Estado de México
Authors:   , Puebla López Susana
Published: February 2022

This research explores the cultural significance of one of the public spaces of the old center of Atizapan of Zaragoza. The atrium and the church of Saint Francis of Assisi, in the State of Mexico, dating from the end of the century XVIII. An architectural complex with enormous historical richness where it is important to enhance the origins and the preponderant role in which they are part of the daily life of the community and its visitors. The study has been employed to analyze the evolution and function of the atrium space in comparison to what has become nowadays. Therefore, it is a deteriorated space that needs a landscape recovery in order to enrich its visual quality to recover the cultural and natural value as historical heritage. It is necessary, however, to understand concepts such as landscape and its variants, environmental and natural systems, principles and problems of design, to name a few, which will be applied to the activities that take place day by day in the atrium immersed in an urban environment chaotic. These concepts will help to analyze the evolution of the atrium through time to discover the spirit of the place, the genius loci, methodological tools will be used and with the help of the basic components of Landscape Architecture, sociocultural problems that generate dissonances will be identified, that demerit the harmonious enjoyment of the open space and, consequently, they hide the patrimonial, natural and cultural value that threatens this area so important for the community. Once these objectives are met, the needs that will enrich the spatial unit can be satisfied through the conceptualization of design proposals that return the landscape quality to the atrium to contemplate the search for conservation and management, as well as legal issues to ensure its protection, with Conscious glances at the past, present and future, not only with the justification of its value as natural heritage, but also for the environmental benefit that is generated in favor of users.
Os movimentos metafísicos da Filosofia Portuguesa Contemporânea
Authors: Dimas Samuel
Published: February 2022

Este artigo tem como objetivo identificar no pensamento português contemporâneo as suas principais correntes metafísicas e os filósofos a elas associados. Procura, igualmente, caracterizar a especificidade da filosofia portuguesa no contexto europeu, que se traduz na sua teoria da saudade e na tradicional relação umbilical com a literatura e a teologia, nomeadamente, na forma poética e na expressão mística ou espiritual. Assumindo a íntima união entre a razão e a emoção, a razão e a fé, o entendimento e a experiência, a metafísica portuguesa está centrada nas noções de Mistério e Excesso e procura uma incessante superação dos monismos panteístas e dos dualismos deístas. O resultado traduz-se na assunção de três vias fundamentais: a metafísica da cisão e da restauração fundada no pantiteísmo emanatista da união divina impessoal; a metafísica da queda e da redenção, fundada no teísmo da união divina pessoal; a metafísica da criação e da manifestação, fundada no teísmo criacionista da transcendência imanente sob as formas de comunhão pessoal e plenificação universal.
Charakterystyka wybranych zbiorowisk trawiastych w rezerwacie przyrody „Kózki” oraz próba ich czynnej ochrony przez wypas owiec rasy świniarka
Authors: WARDA MARIANNA , KULIK MARIUSZ ARTUR , GRUSZECKI TOMASZ
Published: February 2022

Celem pracy jest charakterystyka wybranych zbiorowisk trawiastych, w tym muraw napiaskowych, w rezerwacie przyrody „Kózki” w aspekcie florystycznym i produkcyjnym oraz możliwości wykorzystania owiec rasy świniarka do ich czynnej ochrony. Badania przeprowadzono w sezonie wegetacyjnym 2010 r., w południowej części rezerwatu „Kózki”, gdzie prowadzono wolny wypas rodzimej rasy owiec świniarka. W badaniach oceniano skład gatunkowy badanych muraw, preferencje pokarmowe owiec, potencjał produkcyjny oraz wartość użytkową runi. Na badanym obszarze wyróżniono zbiorowiska trawiaste z klasy Molinio-Arrhenatheretea, klasy Koelerio glaucae-Corynephoretea canescentis, rzędu Corynephorion canescentis, zespołu Corynephoro-Silenetum tataricae i Caricetum cespitosae. Na podstawie przeprowadzonych badań stwierdzono, że owce rasy świniarka mogą być wykorzystywane do czynnej ochrony muraw napiaskowych z uwagi na hamowanie sukcesji wtórnej roślinności drzewiasto-krzewiastej.
AUTEX 2022 – 21st World Textile Conference Announcement
Authors: Jaszczak Malwina , Sąsiadek-Andrzejczak Elżbieta , Grabowska Katarzyna
Published: February 2022

The article is an invitation to the Autex 2022 - 21st World Textile Conference, which is organized by the Faculty of Material Technologies and Textile Design, Lodz University of Technology, Lodz, Poland. The conference will be held ONLINE on the 7th to the 10th June 2022, under the motto Passion for innovation. The conference will be focused on the latest scientific and technical achievements in the field of textiles.
Litterfall nutrient return in thinned young stands with Douglas fir
Authors: Novák Jiří , Kacálek Dušan , Dušek David
Published: February 2022

The use of Douglas fir (DF) is on the increase in the Czech Republic. This tree species shows a good production and also a beneficial impact on soil to some extent. We studied both amount and properties of litterfall in 18 to 20-year-old stands with DF in 2011. Two experimental plots were DF-dominated and one showed ca. 20 – 30% share of Scots pine (SP) at the beginning of observation. The experiments consisted of two treatments such as unthinned control and 50 – 62% trees’ density reduction accounting for 43 – 59% basal area reduction. Litterfall was collected using litter traps of 0.25 m2 area in 3 – 4 traps per treatment. Forest floor L and F were taken in 2011 and 2018 to investigate the development of their amount after thinning. Both whole-period sum and mean annual litterfall were reduced after thinning compared to controls. The mean annual litterfall totaled ca. 3 t ha−1 in 20-year-old DF–dominated stands. This amount represents an annual nutrient return of 30 – 40 kg N, 1 – 3 kg P, 3 – 5 kg K, 12 – 30 kg Ca and 1 – 2 kg Mg per one hectare. The reduction of the annual litterfall was more pronounced in DF–dominated stands. All thinned plots showed increased decomposition rates reflected in lower total L+F amounts in both DF–dominated plots whereas unthinned plots accumulated more L+F at the end. The mixed DF–SP plot showed reduced L and increased F layer amounts in both unthinned and thinned treatments with only minor change to L+F sum between 2011 and 2018.
CART_based Approach for Discovering Emerging Patterns in Iraqi Biochemical Dataset
Authors: Sameer Sarah , Behadili Suhad Faisal , Abd Mustafa S. , Salam Ali
Published: February 2022

This paper is intended to apply data mining techniques for real Iraqi biochemical dataset to discover hidden patterns within tests relationships. It is worth noting that preprocessing steps take remarkable efforts to handle this type of data, since it is pure data set with so many null values reaching a ratio of 94.8%, then it becomes 0% after achieving these steps. However, in order to apply Classification And Regression Tree (CART) algorithm, several tests were assumed as classes, because of the dataset was unlabeled. Which then enabled discovery of patterns of tests relationships, that consequently, extends its impact on patients’ health, since it will assist in determining test values by performing only relevant tests. Therefore decreases the number of tests for patients.
Versos ecfrásticos: Estácio, Tebaida, 2. 215-223; 6. 531-547 e 9. 332-338
Authors: Messeder Moura Fernanda
Published: February 2022

Neste artigo apresento e analiso três exemplos de écfrase na Tebaida. Demonstro como esse recurso poético se insere na longa tradição de autores cuidadosamente emulados por Estácio. Examino ainda a écfrase em seu uso em versos anterior mesmo a sua formulação retorica, variada, mas não exaustiva, que lhe tem sido dada desde a antiguidade.
PERINTISAN RUMAH BACA "SERA CENDEKIA" SEBAGAI UPAYA PENGEMBANGAN GENERASI GEMAR MEMBACA DI PERUMAHAN PURI KRAKATAU HIJAU CILEGON
Authors: Gentari Ratu Erlina , Kodriyah Kodriyah , Wijaya Herman
Published: February 2022

The main focus of this community service program is to provide socialization and pioneering of reading houses to children so that their love of reading grows, and that their love of reading becomes a necessity for seeking knowledge. This service activity was carried out at the Puri Krakatau Hijau Housing, Kotasari Village, Grogol District, Cilegon City, Banten Province. The condition of housing that does not have reading house facilities plus the location of the regional library is quite far, located in Cilegon City. This causes children to be reluctant to read, in addition, with the current Covid-19 pandemic condition which requires children not to leave the house or the surrounding environment. The Reading House "Sera Cendikia" is here to answer the problems that occur in the Puri Krakatau Hijau housing. The target to be achieved through this service program is the fulfillment of children's rights to education and so that children become fond of reading. The method used is the Glenn Doma Method, which is a method of teaching reading to children using flash cards so that children will have a sense of confidence, imagenative, and happyness. Education at the basic level is currently often neglected with information technology, even though it is precisely at the basic level that the role of learning begins to be applied, the results obtained are that there is an increase in learning outcomes with this method by 60% of learning.
PENINGKATAN PRODUKTIFITAS PADA UNIT PRODUKSI GULA SAGU UP2K SUNGAI TOHOR MELALUI PENERAPAN TEKNIK PENGERINGAN DENGAN CABINATE DRYER SAGO SUGAR
Authors: Hafidawati Hafidawati , Irfandy Bagus Duhan , Islamy Muhammad Agung , Zaidan Muhammad Zahran , Khairany Septy
Published: February 2022

Sungai Tohor Village is located in East Tebing Tinggi District, Meranti Islands Regency, Riau Province which has great potential in the field of processing sago plants. In Sungai Tohor Village, there is a Family Income Improvement Business unit (UP2K) which has produced and marketed processed sago palm products in the form of sago sugar. Sago sugar has more advantages compared to other types of sugar besides its relatively cheap price, this sugar also has a low glycemic level making it suitable for people with diabetes. However, high market demand with low production capacity makes it difficult for sago sugar to meet the target. These problems arise because the production time of sago sugar is quite long around 4-5 days, this is due to the traditional drying of sugar because there is no technology that can be used in drying sago sugar effectively and efficiently. The purpose of this activity is to transfer knowledge and assistance in the process of drying the product. The method used is training and practice by the PKM-PI team at the University of Riau regarding the use of drying technology with the Cabinet Dryer Sago Sugar (CADESAR) drying device. Drying technology using CADESAR can improve the quantity and quality of sago sugar products. This technology can reduce production time by using a pressurized hot steam drying system, as one of the drying methods in the modern sugar industry, so that it can increase the amount of production and be more hygienic. The results of the training show that UP2K members can understand and practice knowledge of drying technology well. It is hoped that this will increase the productivity of their sago sugar business.
PERCONTOHAN PAGAR PENGAMAN RUANG TERBUKA DI KELURAHAN KALIANYAR
Authors: Winandari Maria Immaculata Ririk , Wijayanto Punto , Handjajanti Sri , Iskandar Juliandini , Eki Aurum Obe Titu
Published: February 2022

Kalianyar settlement has the highest density in Indonesia. These conditions make this settlement vulnerable to fire hazards. The need for open space, the dense environmental conditions, as well as the possibility of fire hazards require residents to prepare for the disaster threat. Understanding and skills regarding the disaster mitigation development and maintenance of open space is necessary to maximize the use of space, to improve the quality of the environment, as well as the skills of citizens. Community action plan is very important to improve the environment quality. The aim of this program is to provide a safety fence based on community action plan. The method used in this program is assisting the development process. This program can optimize the use of space while improving the environment quality. Participants were neighborhood officers and residents at RT 02 RW 07. The result showed that the sense of belonging to the open space can be improved through the fence construction pilot project. The sense of belonging is shown by painting the safety fence independently by residents.
PENDAMPINGAN DIGITAL MARKETING: TIPS BERJUALAN DAN BERIKLAN MELALUI INSTAADS
Authors: Nurhaida Dida , Dizar Shafrani , Alisa Irma Ade , Kartini Ai , Suteja Syalendra Malik , Hasna Thazqia Dhia
Published: February 2022

The purpose of this community development activity is to equip partner with skills in utilizing  social media accounts  Instagram as a tool for promotion and online sales of potato chip products produced by the partner by online through direct mentoring. The material provided starts from an introduction to the features on Instargam and their functions, and then tutorials in creating interesting content and photos to increase promotions, as well as tips and tricks on how to post and advertise on Instagram. From the results of the mentoring activities, it can be seen that partners are able to make marketing plans and utilize Instagram social media independently. Partners have started to actively update and post regularly with interesting content and captions. The activity ends with the evaluation of  effectiveness activity by monitoring the development of the skills and her business  for three months.
American Physical Therapy Association Clinical Practice Guideline Implementation for Neck and Low Back Pain in Outpatient Physical Therapy: A Nonrandomized, Cross-sectional Stepped-Wedge Pilot Study
Authors: Beneciuk Jason M. , Osborne Raine , Hagist Michael B. , Crittenden Jane , Buzzanca Katherine E. , Gao Hanzhi , Wu Samuel S.
Published: February 2022

Objective

To determine whether a multifaceted implementation strategy for American Physical Therapy Association neck and low back pain clinical practice guidelines (CPGs) was associated with changes in clinician and patient outcomes.

Design

Cross-sectional stepped-wedge pilot study.

Methods

Physical therapy clinics (n = 9) were allocated to 1 of 4 clusters that varied by CPG implementation timing. Clinics crossed over from usual care (control) to CPG implementation (intervention) every 8 weeks and ended with a 24-week follow-up period. Implementation outcomes were measured at the clinician (perspectives and behaviors) and patient (pain and disability outcomes) levels. Descriptive statistics were used to summarize clinician perspectives and behaviors. Generalized linear mixed models were used to analyze patient-level outcomes data (pain and disability) and total number of physical therapy visits.

Results

Improvements in several clinician perspectives about CPGs were observed 8 weeks after training and sustained at 16 weeks (P<.05), although it is unclear whether these changes were meaningful. Training on CPGs was relevant to physical therapists and more acceptable at 16 weeks (P<.05). In a random sample (n = 764/1994, 38.3%), the overall rate of CPG classification was 65.0% (n = 497/764), and CPG intervention concordance was 71.2% (n = 354/497). Implementation of a CPG was not associated with final pain and disability scores (P>.05) but was associated with an approximate increase of 8% in total visits.

Conclusion

Our multifaceted implementation strategy was associated with statistical changes in clinician perspectives and behaviors, but not in patient outcomes. J Orthop Sports Phys Ther 2022;52(2):113–123. doi:10.2519/jospt.2022.10545
FORMATION OF THE DESIGN IMAGE OF A NANOSATELLITE REFUELING STATION WITH ELECTROTHERMAL PROPULSION SYSTEMS
Authors:   Omsk State Technical University, Omsk, Russia, Blinov V. N. , Kositsin V. V. ,   Omsk State Technical University, Lukyanchik A. I. ,   Omsk State Technical University, Stepen P. V. ,   Omsk State Technical University, Yachmenev P. S. ,   Omsk State Technical University
Published: February 2022

Целью исследований является определение проектно-конструктивного облика универсальной заправочной станции корректирующих двигательных установок наноспутников. Разработаны пневмогидравлические схемы модулей заправочной станции. Разработан и изготовлен модуль фильтрации рабочего тела. В соответствии с требованиями к заправке наноспутников разработана технология заправки двигательной установки наноспутника самонаддуваемым фреоном
A new genus of the subfamily Languriinae (Coleoptera: Erotylidae) from the Late Eocene Baltic amber
Authors:   The Andrzej Myrcha University Natural Science Centre, University of Bialystok, K. Ciolkowskiego 1J, 15-245 Białystok, Poland, Kupryjanowicz J. , Lyubarsky G.Yu. ,   Zoological Museum of Moscow State University, Gerzen str. 2, Moscow, 105009, Russia, Perkovsky E.E. ,   Schmalhausen Institute of Zoology, NAS of Ukraine, B. Khmelnitskogo str. 15, Kiev, 01030, Ukraine,   Paleontological Institute, RAS, Profsoyuznaya 123, Moscow, 117647, Russia
Published: February 2022

Thallisellites olgae gen. et sp. n. (Erotylidae: Languriinae, Thallisellini) is described from the Late Eocene Baltic amber. Extant species of the tribe Thallisellini are all of a neotropical distribution. The new genus is similar to the extinct Serramorphus Lyubarsky et Perkovsky, 2017 from Bitterfeld amber. The new genus differs from Serramorphus by the smooth, rounded and not dentate lateral margin of the pronotum (in Serramorphus, the lateral margin is sinuous and spinose). New genus is considered monotypic and differs from extant genera of Thallisellini primarily in the strongly developed anterolateral angles of the pronotum. Family Tarsonemidae (Acari) is reported from the Baltic amber for the first time.
A Geographical Study of Rural Out migration and Demographic Changes in Hilly State Uttarakhand
Authors: Lal Mohan , Ahmad Vaseem , Nand Kevla
Published: February 2022

Migration and demographic changes are the major concerns of population geography. However, in other social disciplines, different aspects of migration and demographic changes are studied based on the subject's basic principles. The present study examines linkages between rural out-migration and demographic patterns (changes) in Himalayan State Uttarakhand where subsistence agriculture constitutes the main source of food and rural livelihoods although the availability of arable land is severely limited and crop productivity is very low. The constraints of the subsistence economy and basic facilities compel a large proportion of the adult male population to out migrate from the mountain region in search of livelihoods, employment and basic requirements. Hilly region of Uttarakhand has approximately 48% population with 86.08 km2 geographical area while 52 % population of the State resides in very low geographical area which is 13.93 km2.Also, the lack of basic facilities (communication, transportation, healthcare facilities, educational and recreational facilities), changing climatic conditions and natural disasters are becoming the major reasons for outbound migration of the rural working population. As per an analysis, the rate of population growth in 11 districts of the State has rapidly increased while two regions Pauri Garhwal and Almora have noted a negative decadal growth, with Pauri Garhwal, Rudraprayag and Pithoragarh having the highest number of uninhabited villages in Uttarakhand. Generally, negative growth affects growth, the demographic composition and population distribution as well as social, cultural and economic activities.
Development of spectrophotometric method for analysis of mercaptopurine and dimercaprol for use in quality control and monitoring water pollution
Authors: Singh Jasvir
Published: February 2022

In the present work, spectrophotometric method was developed for analysis of mercaptopurine and dimercaprol to be applied in quality control and monitoring water pollution. These drugs are used for the treatment of cancer and heavy metal poisoning respectively. Both mercaptopurine and dimercaprol react with colourless anhydrous manganese (II) acetate in DMSO to form soluble brown coloured complexes which showed λmax at 350 nm and 360nm during spectrophotometric analysis. This newly developed method was successfully applied for analysis of commercial drugs and spiked water. The recovery of these drugs from commercial formulations and spiked water samples was in the range between 98.0-99.7% with RSDs in the range 0.56-1.50% that indicated high degree of accuracy and precision of the method.
In vivo synergistic antibiofilm activity of Curcumin Silver Nanoparticles against UTI causing colistin resistance E.coli
Authors: Malathi S. , Jagathy K.
Published: February 2022

Biofilm resilence has become a serious issue in the treatment of urinary tract infection leading to the resistance to various antibiotics. There is a rapid need to develop new antibacterial agents or amalgamation drug therapies. Silver nanoparticles (AgNPs) are used as an anti-biofilm agent for the treatment of urinary tract infections. Meanwhile curcumin, a phenolic plant extract is also acting as natural anti-biofilm agent. The objective of this study was to analyse the amalgamation of AgNPs and curcumin nanoparticles (Cur-NPs) against gram-negative E.coli at 100 μg/mL. This disrupted 50% of established bacterial biofilms. Scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM) revealed that amalgamation therapy (Cur-SNPs) was the most vigorous to destruct preformed biofilm.
LESSON STUDY STRENGTHENING TRAINING FOR YOUNG LECTURERS TO IMPROVE LECTURE QUALITY
Authors: Martono Martono , Hairida Hairida , Oktavianty* Erwina , Marlina Reni , Yansa Hemri
Published: February 2022

This article aims to describe the implementation of socialization activities and technical guidance for the implementation of Lesson Study for young lecturers in the Faculty of Teacher Training and Education, Tanjungpura University (University) and to explore information about participants' opinions on the implementation of lesson study in lectures. Opinions were obtained from the stages of socialization and technical guidance on the implementation of the learning quality improvement program through Lesson study. This activity is carried out in two stages. Phase 1 is a field orientation activity carried out by the team, the purpose of this activity is to prepare activities and collect data on young lecturers (CPNS) who are in the teacher training institution at university environment. Phase 2 is a lesson study cycle socialization and technical guidance activity which was carried out in a 4-hour meeting on 27 July 2020 at the teacher training institution University. In this activity, 4 team members as resource persons were present to provide strengthening of lesson study to participants in the socialization and technical guidance, besides that this activity was also attended by 29 participants who were young lecturers in the faculty. With these stages, it is hoped that this community services activity can produce an understanding of sustainable programs for young lecturers in order to improve the quality of professional lecturers and can improve the quality of learning so that it results in increased results and learning processes for students. So that in the end it can build a learning community that affects the improvement of the quality of education.Keyword: Lesson Study, Young Teachers, Community Services
STRATEGI PEMBELAJARAN BAHASA MANDARIN PADA MAHASISWA ANGKATAN 2019 PROGRAM STUDI PENDIDIKAN BAHASA MANDARIN
Authors: Ina Ina , Khiong Bun Yan , Afrimonika Yoanna
Published: February 2022

Mandarin is a foreign language that is quite popular to learn nowadays. Many companies require their workers to have the ability to speak Mandarin. Mandarin has its peculiarities in pronunciation, Chinese or Chinese characters, vocabulary, and grammar. Therefore, learning Mandarin as a second language is not the same as copying from learning other foreign languages as a second language. So far, Chinese learning has focused more on how to teach a particular material. However, how students learn to affect their success in learning Mandarin is under study. This research will study the strategies used by students in learning pronunciation, Chinese characters, vocabulary, and grammar. The information obtained through the questionnaire summarizes the learning strategies that students have carried out. The conclusions obtained will be used as a scientific basis for lecturers who support courses related to pronunciation skills, mastery of mandarin letters and vocabulary, and skills in using grammar to provide direction and guidance to students on effective learning strategies.Abstrak Bahasa Mandarin merupakan bahasa asing yang cukup populer dipelajari pada saat ini. Hal ini dilatarbelakangi oleh permintaan tenaga kerja yang memiliki kemampuan berbahasa Mandarin. Bahasa Mandarin memiliki kekhasannya sendiri dalam pelafalan, huruf Mandarin atau Hanzi, kosakata dan tata bahasa. Oleh karena itu, pembelajaran bahasa Mandarin sebagai bahasa kedua tidak sama persis atau bukan copy paste dari pembelajaran bahasa asing lainnya sebagai bahasa kedua. Selama ini, pembelajaran bahasa Mandarin lebih berfokus pada bagaimana cara dosen mengajarkan suatu materi tertentu. Aspek bagaimana si mahasiswa belajar kurang diperhatikan, sehingga keberhasilan mahasiswa dalam mempelajari bahasa Mandarin juga ikut terpengaruh. Penelitian ini akan difokuskan pada strategi yang digunakan mahasiswa dalam belajar pelafalan, huruf Mandarin, kosakata dan tata bahasa. Informasi yang diperoleh lewat kuesioner diharapkan dapat memberikan rangkuman tentang strategi-strategi pembelajaran yang telah dilakukan oleh mahasiswa. Kesimpulan yang didapat akan digunakan sebagai dasar ilmiah kepada dosen pengampu mata kuliah yang berkaitan dengan keterampilan pelafalan, penguasaan huruf mandarin dan kosakata serta keterampilan penggunaan tata bahasa untuk memberikan arahan dan bimbingan kepada mahasiswa tentang strategi belajar yang efektif.
NARRATIVE PARAGRAPH COMPOSITION: A DESCRIPTION OF EFL LEARNERS’ PROFICIENCY IN USING PAST TENSE
Authors: Rusmiati Rusmiati
Published: February 2022

It is unavoidable that writing becomes a compulsory subject in English Department as it is one of notable skills that ought to be acquired by English language learners. They are demanded to possess a better writing proficiency after taking certain writing subjects. Nonetheless, writing is perceived as the most troublesome English language learning capability since it constitutes a productive skill. To specify, expressing ideas and using grammatically correct language are considered quite challenging for students. This study, accordingly, was carried out to investigate the learners’ writing production to find out their expertise in composing a past narrative paragraph in particular. Therefore, fourteen compositions of second semester students in academic year 2018/2019 were employed in this investigation. The findings show that most of them composed narrative paragraph precisely, i.e. by applying chronological development or time order. That notwithstanding, the majority of them used verb tense incorrectly in their past narrative composition.
INVESTASI SUMBER DAYA MANUSIA DALAM MENINGKATKAN MUTU PENDIDIKAN DI INDONESIA
Authors: Hardianto Hardianto , Nofriser Nofriser
Published: February 2022

The problems of education today can be classified into three main problems, namely equity, quality and relevance. This research method is literature study with editing, organizing and finding steps. Data analysis used deductive and inductive techniques. The results of the study are known to overcome educational problems, one of which is by investing in human resources. Investment in human resources will be able to increase the competitiveness of educational institutions. Human capital includes intellectual, emotional, social, fortitude and moral capital. Education is said to be of quality if it meets or exceeds customer expectations both internally and externally. Therefore, improving the quality of education needs to be done by encouraging educators and education staff to increase their knowledge about their work through training, workshops and further studies. AbstrakPermasalahan pendidikan dewasa ini dapat diklasifikasikan menjadi tiga permasalahan utama, yaitu pemerataan, kualitas dan relevansi. Metode penelitian ini adalah studi pustaka dengan langkah-langkah editing, organizing dan finding. Analisis data menggunakan teknik deduktif dan induktif. Hasil penelitian diketahui untuk mengatasi permasalahan pendidikan salah satunya dengan melakukan investasi sumber daya manusia. Investasi sumber daya manusia akan dapat meningkatkan daya saing lembaga pendidikan. Modal manusia meliputi modal intelektual, emosional, sosial, ketabahan dan moral. Pendidikan dikatakan bermutu apabila memenuhi atau melebihi harapan pelanggan baik internal maupun eksternal. Oleh karena itu peningkatan mutu pendidikan perlu dilakukan dengan mendorong tenaga pendidik dan kependidikan untuk meningkatkan pengetahuan tentang pekerjaannya mereka melalui pelatihan, workshop maupun studi lanjut.
MODEL KONSEPTUAL PELATIHAN CEFE UNTUK MENINGKATKAN KEMANDIRIAN UMKM DI KOTA CIMAHI PROVINSI JAWA BARAT
Authors: Sukmana Cucu , Hatimah Ihat , Wahyudin Uyu , Akhyadi Ade Sadikin
Published: February 2022

This study aims to to provide a study by describing the conceptual model of CEFE training in perfecting the entrepreneurship training program.method applied is a qualitative approach with Emic's view, then data collection involves MSME actors, assistants, and coordinators as well as data collection tools by observation, documentation, interviews, and tests. Based on the results of the study, it was found that the conceptual model of CEFE training was very helpful in training management and specifically to deal with problems in the business world, then based on the discussion conducted on the conceptual model of the training it was more structured and focused when compared to not implementing the training model, then this management applied real simulation into the world of entrepreneurship which makes this model very suitable to be applied to entrepreneurship training programs. The impact of this research is to create insight into job opportunities, increase entrepreneurial insight and create a family spirit, as well as train participants to develop businesses through business partners. AbstrakPenelitian ini bertujuan untuk memberikan kajian dengan mendeskripsikan model konseptual pelatihan CEFE dalam menyempurnakan program pelatihan kewirausahaan. Metode penelitian yang diterapkan adalah pendekatan kualitatif dengan pandangan Emic, kemudian pengumpulan data melibatkan pelaku UMKM, pendamping, dan koordinator serta alat pengumpulan data dengan observasi, dokumentasi, wawancara, dan tes. Berdasarkan hasil penelitian didapatkan bahwa model konseptual pelatihan CEFE sangat membantu dalam manajemen pelatihan dan khusus untuk menangani permasalahan di dunia usaha, kemudian berdasarkan pembahasan yang dilakukan mengenai model konseptual pelatihan tersebut lebih terstruktur dan fokus jika dibandingkan dengan tidak menerapkan model pelatihan, kemudian pada manajemen ini menerapkan simuasi nyata ke dunia wirausaha yang membuah model ini menerpkan simulasi model pelatihan, kemudian pada manajemen ini menerapkan simulasi nyata ke dunia wirausaha yang membuat model ini sangat cocok untuk diterapkan pada program pelatihan kewirausahaan. Dampak dari penelitian ini adalah menciptakan wawasan peluang kerja, menambah wawasan kewirausahaan dan menciptakan semangat kekeluargaan, serta melatih peserta untuk mengembangkan usaha melalui mitra usaha.
Government as a Platform? The Power of Platforms to Support Personalization of Public Services
Authors: Bender Benedict , Heine Moreen
Published: February 2022

Digital platforms, by their design, allow the coordination of multiple entities to achieve a common goal. In the public sector, different understandings of the platform concept prevail. To guide the development and further re-search a coherent understanding is required. To address this gap, we identify the constitutive elements of platforms in the public sector. Moreover, their potential to coordinate partially autonomous entities as typical for federal organized states is highlighted. This study contributes through a uniform understanding of public service platforms by providing a framework with constitutive elements, that may guide future analysis. Apart from chance regarding coordination, platforms are well suited to support contextual eGovernment targets. Among them is service personalization. Highly individualized service offerings support targets such as No Stop government. To this end, the paper extends the framework for service personalization in the public sector and exemplifies related aspects using a reference case.
A simple predictor of interface orientation of fluids of disk-like anisotropic particles and its implications for organic semiconductors
Authors: Boehm Belinda , Huang David
Published: February 2022

From classical molecular dynamics simulations, we identify a simple and general predictor of molecular orientation at solid and vapour interfaces of isotropic fluids of disk-like anisotropic particles based on their shape and interaction anisotropy. For a wide variety of inter-particle interactions, temperatures, and substrate types within the range of typical organic semiconductors and their processing conditions, we find remarkable universal scaling of the orientation at the interface with the free energy calculated from pair interactions between close-packed nearest neighbours and an empirically derived universal relationship between the entropy and the shape anisotropy and bulk volume fraction of the fluid particles. The face-on orientation of fluid particles at the solid interface is generally predicted to be the equilibrium structure, although the alignment can be controlled by tuning the particle shape and substrate type, while changing the strength of fluid--fluid interactions is likely to play a less effective role. At the vapour interface, only the side-on structure is predicted, and conditions for which the face-on structure may be preferred, such as low temperature, low interaction anisotropy, or low shape anisotropy, are likely to result in little orientation preference (due to the low anisotropy) or be associated with a phase transition to an anisotropic bulk phase for systems with interactions in the range of typical organic semiconductors. Based on these results, we propose a set of guidelines for the rational design and processing of organic semiconductors to achieve a target orientation at a solid or vapour interface.
All-Atom Simulations Uncover Structural and Dynamical Properties of STING Proteins in the Membrane System
Authors: Payne Rachel , Crivelli Silvia , Watanabe Masakatsu
Published: February 2022

Recent studies have shown that the stimulator of interferon gene (STING) protein plays a central role in the immune system by facilitating the production of Type I interferons in cells. The STING signaling pathway is also a prominent activator of cancer-killing T cells that initiates a powerful adaptive immune response. Since biomolecular signaling pathways are complicated and not easily identified through traditional experiments, molecular dynamics (MD) has often been used to study these biological pathways’ structural and dynamical responses. Here, we carried out MD simulations for full-length chicken and human STING (chSTING and hSTING) proteins. Specifically, we investigated ligand-bound closed and ligand-unbound open forms of each STING in the membrane system by comparing conformational and dynamical differences among them. Our research provides clues for understanding the mechanism of the STING signaling pathway by uncovering some detailed insights for the examined systems: the residues from each chain in the binding pocket are strongly correlated to one another in the open STING structure compared with those in the closed STING structure. Ligand-bound closed STING displays approximately 170° rotation of the ligand-binding domain (LBD) relative to the open-STING structure. The detailed dynamical analysis of residue Cys148 in the linker region of hSTING does not support the earlier hypothesis that Cys148 can form disulfide bonds between adjacent STING dimers. We also reveal that using the full-length proteins is critical as the MD simulations of the LBD portion only cannot properly describe the global conformational properties of multiple domain proteins, such as STING.
Single Molecule Magnetism in Linear Fe(I) Complexes with Aufbau and non-Aufbau ground-state
Authors: Khurana Rishu , Ali Md. Ehesan
Published: February 2022

With the ongoing efforts on synthesizing mono-nuclear single-ion magnets (SIMs) with promising applications in high-density data storage and spintronics devices, the linear Fe(I) complexes emerge as the enticing candidates possessing large unquenched angular momentum. Herein, we have studied five experimentally synthesized linear Fe(I) complexes to uncover the origin of single-molecule magnetic behavior of these complexes. To begin with, we benchmarked our methodology on the experimentally and theoretically well-studied complex, [Fe{C(SiMe3)}3]−1] (1) (SiMe3 = trimethylsilyl) which is characterized with large spin-reversal barrier of 226 cm−1 [Nat. Chem. 2013, 5, 577–581]. Further, the two Fe(I) complexes, i.e., [Fe(cyIDep)2]+1 (2) ((cyIDep= 1,3-bis(20,60-diethylphenyl)-4,5-(CH2)4-imidazol-2-ylidene) and [Fe(sIDep)2]+1] (3) (sIDep = 1,3-bis(20,60-diethylphenyl)-imidazolin-2-ylidene) are studied that do not possess SIM behavior under ac or dc magnetic fields, however, they are reported to exhibit large opposite axial zero field splitting (-62.4 and +34.0 cm−1 respectively) from ab initio calculations. Employing state-of-the-art ab initio calculations, we have unwrapped the origin of this contrasting observation between experiment and theory by probing their magnetic relaxation pathways and the pattern of d-orbitals splitting. Additionally, the two experimentally synthesized Fe(I) complexes, i.e., [(η6-C6H6)FeAr*-3,5-Pri 2] (4) (Ar*-3,5-Pri 2 = C6H-2,6-(C6H2-2,4,6-Pri 3)2-3,5-Pri 2) and [(CAAC)2Fe]+1 (5) (CAAC = cyclic (alkyl)(amino)carbene) are investigated for SIM behavior, since there is no report on their magnetic properties. To this end, complex 4 presents itself as the potential candidate for SIM.
Evaluating the use of absolute binding free energy in the fragment optimization process.
Authors: Alibay Irfan , Magarkar Aniket , Seeliger Daniel , Biggin Philip
Published: February 2022

Key to the fragment optimization process is the need to accurately capture the changes in affinity that are associated with a given set of chemical modifications. Due to the weakly binding nature of fragments, this has proven to be a challenging task, despite recent advancements in leveraging experimental and computational methods. In this work, we evaluate the use of Absolute Binding Free Energy (ABFE) calculations in guiding fragment optimization decisions, retrospectively calculating binding free energies for 59 ligands across 4 fragment elaboration campaigns. We first demonstrate that ABFEs can be used to accurately rank fragment-sized binders with an overall Spearman’s r of 0.89 and a Kendall τ of 0.67, although often deviating from experiment in absolute free energy values with an RMSE of 2.75 kcal/mol. We then also show that in several cases, retrospective fragment optimization decisions can be supported by the ABFE calculations. Cases that were not supported were often limited by large uncertainties in the free energy estimates, however generally the right direction in ΔΔG is still observed. Comparing against cheaper endpoint methods, namely Nwat-MM/GBSA, we find that ABFEs offer better outcomes in ranking binders, improving correlation metrics, although a similar confidence in retrospective synthetic decisions is achieved. Our results indicate that ABFE calculations are currently at the level of accuracy that can be usefully employed to gauge which fragment elaborations are likely to offer the best gains in affinity.
Computational Modeling of Conformer Stability in Benenodin-1, A Thermally-Actuated Lasso Peptide Switch
Authors: Yang Zhongyue , Hajlasz Natalia , Kulik Heather
Published: February 2022

Benenodin-1 is a thermally-actuated lasso peptide rotaxane switch with two primary translational isomers that differ in the relative position of residue Gln15. The conversion from one conformer to the other involves substantial enthalpy-entropy compensation: one conformer is energetically-favored and the other is entropically-favored. Here, we take a multi-scale quantum mechanical (QM) and classical molecular dynamics (MD) approach to reveal residue-specific sources of these differences in stability. QM reveals that the two benenodin-1 conformers involve distinct hydrogen bonding networks, with the enthalpically-favored conformer having more intra-peptide hydrogen bonds between Gln15 sidechain and nearby residues. Evaluation of configurational entropy over the MD-sampled geometries reveals that the entropically-favored conformer has enhanced conformational flexibility. By computing the by-residue-sum entropies, we identify the role of Gln15 and neighboring Glu14 in mediating the entropic variation during the switching process. These computational insights help explain the effects of Glu14Ala and Gln15Ala mutations on the conformational population of benenodin-1 observed experimentally.
VIRTUAL SCREENING OF CYANOBACTERIAL METABOLITES AS INHIBITORS OF SARS-CoV-2 HOST CELL ENTRY, VIRAL REPLICATION, AND HOST IMMUNITY MODULATION INFECTIVE MECHANISMS
Authors: Fellizar Viktor Aloysius , Concepcion Aaron Cyrus , Furaque Emmanuel Louise , Fabian Angela Maxine , de Leon Von Novi , Pilapil Delfin Yñigo IV , Quimque Mark Tristan , Notarte Kin Israel , Macabeo Allan Patrick
Published: February 2022

The novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) emerged in December 2019 leading to a global pandemic and lockdowns in different countries including the Philippines. There is an oral antiviral treatment, Paxlovid, produced by Pfizer that is currently authorized for emergency use to treat COVID-19. However, there is still a necessity to discover specific antiviral drugs due to increasing cases worldwide. In this study, 56 cyanobacterial secondary metabolites were virtually screened for in silico inhibitory prospects against five main targeted proteins of SARS-CoV-2 involved in viral attachment, viral replication, and host immunity modulation mechanisms. Pharmacokinetic properties and toxicity predictions were also performed. Of the fifty-six secondary metabolites molecularly docked, compounds 1–7 showed favorable binding energy ranging from -10.9 to -8.0 kcal/mol against the spike’s ACE2 (angiotensin-converting enzyme 2) and GRP 78 (glucose-related protein 78) receptor binding domains, 3CLPRO (3-chymotrypsin-like protease), PLPRO (papain-like protease), and RdRp (RNA-dependent RNA-polymerase). Three compounds, scytonemin (1) a bisindole alkaloid dimer, cryptophycin (5) a macrolactam, and tjipanazole A2 (6) an indole alkaloid glucoside exhibited highest the binding affinities with BE’s ranging from -10.4 to -8.6 kcal/mol. Top-ranked ligands 1–7 also demonstrated favorable pharmacokinetics with low toxicity risks.
A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo
Authors: Kofink Christiane , Trainor Nicole , Mair Barbara , Wöhrle Simon , Wurm Melanie , Mischerikow Nikolai , Bader Gerd , Rumpel Klaus , Gerstberger Thomas , Cui Yunhai , Greb Peter , Garavel Geraldine , Scharnweber Maximilian , Fuchs Julian , Gremel Gabriela , Chette Paolo , Hopf Stefan , Budano Nicole , Rinnenthal Jörg , Gmaschitz Gerhard , Diers Emelyne , McLennan Ross , Roy Michael , Whitworth Claire , Vetma Vesna , Mayer Moriz , Koegl Manfred , Ciulli Alessio , Weinstabl Harald , Farnaby William
Published: February 2022

Targeted protein degradation offers an alternative modality to classical inhibition and holds the promise of addressing previously undruggable targets to provide novel therapeutic options for patients. Heterobifunctional molecules co-recruit the target and an E3 ligase, resulting in ubiquitylation and proteosome-dependent degradation of the target. The oral route of administration is the option of choice in the clinic, but has only been achieved so far by CRBN- recruiting bifunctional degrader molecules. We aimed to achieve orally bioavailable molecules that selectively degrade the BAF Chromatin Remodelling complex ATPase SMARCA2 over its closely related paralogue SMARCA4, to allow in vivo evaluation of the synthetic lethality concept of SMARCA2 dependency in SMARCA4 deficient cancers. Here we outline structure- and property-guided approaches that led to the first orally bioavailable VHL-recruiting degraders. Our tool compound, ACBI2, shows selective degradation of SMARCA2 over SMARCA4 in ex vivo human whole blood assays and in vivo efficacy in SMARCA4-deficient cancer models. This study demonstrates the feasibility for broadening the E3 ligase and physicochemical space that can be utilised for achieving oral efficacy with bifunctional molecules.