bluuebunny/crossref_metadata_2025 huggingface dataset:
Des mathématiques à la docte ignorance selon Nicolas de Cues
Authors: Pasqua Hervé
Published: February 2025

La vérité mathématique se propose à Nicolas de Cues comme précision absolue : un égale un. Sur ce modèle, il définit l’objet de la métaphysique comme l’Un en tant qu’Égalité absolue. En tant que tel, l’Un n’est rien d’étant. Au-delà de l’être, il n’est pas adéquation à l’être, mais égalisation de soi à soi dans le non-être. L’Égalité est sans contenu, elle est un acte pur par lequel l’Un se féconde comme Un. La connaissance n’est donc plus conçue comme adéquation de la pensée à son objet, elle tourne le dos à la définition de la vérité comme adequatio rei et intellectus. La correspondance avec la réalité disparaît. L’approche indéfinie de son objet constitue désormais la connaissance elle-même : approche conjecturale, ou symbolique, d’un objet toujours insaisissable, toujours lointain, reculant toujours à mesure qu’on l’approche. Telle est la méthode – le chemin – de la docte ignorance, qui inaugure la modernité selon Hans Blumenberg.
La philosophie de Bachelard et la connaissance incertaine
Authors: Poinat Sébastien
Published: February 2025

Cet article commence par établir que Bachelard a pensé le savoir scientifique comme un exemple de connaissance incertaine. Il vise ensuite à expliquer comment Bachelard a cherché à se prémunir des deux écueils qui menacent toujours la thèse de la connaissance incertaine, à savoir d’un côté le dogmatisme, de l’autre le scepticisme. Enfin, nous montrons que, selon Bachelard, les philosophies adverses n’ont précisément pas su éviter de tomber dans l’un ou dans l’autre de ces deux pièges.
Green HRM (GHRM) and Green Innovation Performance
Authors: Muafi Muafi , Religia Yoga , Junianta Reynaldi Dwi
Published: February 2025

This study aims to develop a Green Human Resource Management (GHRM) model to enhance green innovation performance through the mediating role of Pro-Environmental Behavior (PEB) and green innovation. Companies are increasingly required to manage the environment sustainably, yet implementing GHRM in SMEs faces challenges like high costs and limited awareness. Using a quantitative approach, surveys and interviews were conducted with key actors in creative SMEs in DIY and Central Java. Structural Equation Modeling (SEM) was used for analysis. Results indicate that GHRM significantly improves green innovation performance via PEB and green innovation. Although challenging, SMEs must gradually implement GHRM with support from various stakeholders. This model is expected to aid in achieving business sustainability in various sectors. Academically, this research contributes to understanding the GHRM-green innovation nexus, while practically, it offers a guide for SMEs to adopt GHRM practices to enhance sustainability.
The TOE-Resource Base Nexus
Authors: Religia Yoga , Ramawati Yussi , Muafi Muafi
Published: February 2025

This research aims to identify the factors influencing Green IT adoption by SMEs in Indonesia to promote sustainability. A quantitative, cross-sectional survey design was employed, targeting SMEs using IT in their operations through purposive sampling. Data analysis included descriptive statistics, validity and reliability tests, and SEM-PLS for structural model analysis. Findings reveal that Green IT adoption is driven by technological, organizational, environmental, and resource-based factors. Integrating the TOE Framework with Resource-Based Theory offers insights into these interactions. Key challenges for SMEs include low awareness of Green IT benefits, poor infrastructure support, and insufficient government regulations. This study develops a theoretical framework for understanding Green IT adoption in Indonesian SMEs. The TOE and RBT integration enhances comprehension of technology adoption in dynamic business environments. Practically, this study aids SMEs in improving efficiency and reducing environmental impact through Green IT adoption.
Future of Smart Manufacturing as an Engine of Prosperity
Authors: Singh Bhupinder , Kaunert Christian , Jermsittiparsert Kittisak , Chandra Saurabh , Jain Ashima
Published: February 2025

Expanding Industry 5.0 introduces a more secure and connected landscape using the Internet of Things (IoT). In simple terms, Industry 5.0 is the human-centric stage of intelligent and connected systems where workers are supplemented with machines that come in overtake roles like monotonous tasks etc. which improves productivity drastically due to humans doing what they do best: think critically amongst other functions. The Industrial Internet of Things (IIoT) provides numerous types of services in large-scale environments, including digital business management spaces and real-time production monitoring or machinery condition tracking. This chapter provides an extensive discussion of the various portions of Industry 5.0 in connection to IoT with a deep dive into smart manufacturing for fault detection and mechanical diagnosis and prognosis.
Future of Education With AI-Assisted Technologies
Authors: Arora Amit Kumar , Kumar Anjan , Tyagi Rashmi , Sharma Shivani , Kumar Anuj , Kumar Santosh
Published: February 2025

By leveraging AI-driven solutions, students also have the ability to adjust learning based on personal preference, with unique content that both improves understanding and boosts interest. Virtual tutors, interactive simulations, and smart assessments allow students to learn at their own pace and get real-time feedback. AI-enabled data analytics tools can spot skill gaps and forecast the likelihood of students that feed back into their re-evaluated teaching and streamline to boost success in the classrooms. AI collaborative platforms create a shared worldwide ecosystem for learning having students from all walks of life. Administrative aspects of teaching like grading and curriculum development are streamlined through automation, enabling educators with more bandwidth for mentorship and innovation. AI-assisting technologies are thus building blocks of a better educational system, with equitable, efficient, and future-proof learning developed by bridging the entry gaps.
Role of Sikhism and Buddhism in Addressing Violence and Enhancing Women's Mental Wellbeing for Enhancing World Peace and Sustainability
Authors: Singh Gurveer , Singh Bhupinder , Raghav Anjali , Ahmed Saquib
Published: February 2025

Violence against women continues to be a global phenomenon that asks societies to turn to solutions based on ethics, compassion, and justice. The leadership qualities rooted in the philosophies of Sikhism and Buddhism can provide deep reflections on tackling violence and all the essential elements that go into creating mental well-being in society for both genders, especially for women. Both religions highlight principles of compassion, equality, and non-violence as foundations of their tenets, ultimately creating frameworks for the reformation of society. Sikhism emboldened by the teachings of Sarbat da Bhala (welfare of all), gender equality, underlines the dignity and rights of women and encourages active resistance to oppression and violence. This chapter explores the teachings, historical contributions, and modern applications of Sikhism and Buddhism in addressing violence and fostering the mental well-being of women.
AI-Driven Intelligent Solutions
Authors: Chandra Saurabh
Published: February 2025

This chapter discusses how machine learning (ML) is transforming the face of anticorruption or anti-fraud landscape in financial institutions. Given that most financial crimes have become much more complex than ever before, traditional methodologies have fallen behind in terms of the detection of these crimes and this has led to a significant spike in false positives and operational inefficiency. Even with its promise, issues like data quality, algorithmic bias, and regulatory compliance continue to be major challenges. Adopting such smart solutions can help organizations bolster their defences against financial crimes while also enhancing broader operational efficiency.
Ethics, Algorithms, and the Rules of Evidence
Authors: Kumar Abhishek Benedict , Sanjaya Karun
Published: February 2025

Forensic intelligence, combined with the power of deep learning, has made significant leaps in revolutionizing crime investigation by allowing law enforcement agencies to process complex data, identify patterns, and predict criminal behaviors with efficiency. Traditional forensic methods can be improved through machine learning techniques and the implementation of natural language processing, which alter digital investigations. A few key ways that these two approaches can benefit computer crime and digital forensic investigations include automating the analysis of evidence, enhancing the accuracy of biometrics, and detecting related hacking activities through traditional forensic methods. It supports data-driven policing and improves the speed of case settlements. Yet, concerns including algorithmic bias, data privacy, and legal admissibility of AI-generated evidence underscore the ethical and social implications of these technologies. This chapter will discuss the transformative power of forensic intelligence and deep learning and its applications, ethics, and future.
Exploring Dimensions of Artificial Intelligence in Criminal Investigations and Technological Aspects
Authors: Mishra Saloni , Hammouch Hind , Arora Manmeet Kaur , Lal Sahil , Saini Hemant Kumar , Upadhyay Anurodh
Published: February 2025

Everything in today's world is related to artificial intelligence. Criminals are becoming advanced and accessing artificial intelligence, causing crime. Hence, there is a strict need of artificial intelligence in crime investigation, too, because traditional ways can't find a criminal who is accessing technology to fulfill his desires. Numerous technical instruments support law enforcement in effectively apprehending offenders. Drones offer surveillance and crime scene views from the air. Surveillance and body-worn cameras both record evidence and improve accountability. Metal detectors assist in locating hidden weapons, and predictive analysis foresees and stops criminal activity. Forensic investigations are aided with lie detectors, DNA, and fingerprints. Although AI has shown promise in advancing justice in a number of situations, administration's lack of technical know-how prevents AI from reaching its full potential.
Machine Learning for Fraud Detection and Financial Crimes
Authors: Manavadaria Manthan S. , Sharma Rohit Kumar , Parasar Anuradha , Chauhan Amit , Jeyaprakash N. , Mohaideen A. , Bhoopathy V.
Published: February 2025

Personal, commercial, and economic impacts of financial fraud are significant. Traditional rule-based fraud detection systems often generate false positives and struggle to adapt to new fraud methods. ML algorithms are examined as an alternative to traditional financial fraud detection methods in this chapter. It explores how supervised, unsupervised, and hybrid models may identify financial data abnormalities and fraud patterns. Money laundering, payments fraud, and other financial crimes are covered in this chapter. Fraud detection is complicated by data imbalance, privacy concerns, and model scalability. It also shows how AI, blockchain, and predictive analytics will fight fraud and secure financial institutions. This chapter reviews how new technology is changing financial crime prevention, using examples from credit card and online retail fraud.
Overview of Integrating Sustainability and Innovation
Authors: Satpathy Ipseeta , Nayak Arpita , Jain Vishal
Published: February 2025

Modern consumer consciousness regarding environmental and social issues is creating a gradual trend towards the combination of sustainability with innovation for improved organizational performance and sustainability. The present paper focuses on the theoretical analysis that can facilitate the integration of sustainability and innovation into the core business processes of an organization. The paper also aims to explain the principles and measures of sustainable innovation, as well as the best strategies for the formation of the sustainability models in business activity. This overview aims at stressing on the possibility for change when it comes to embedding sustainability and innovation together and at providing practical recommendations for organisations aspiring to attain both the sustainable financial performance and the beneficial environmental and social outcomes.
Future Trends in AI and Sustainable Business Practices
Authors: Nandhini R. , Chandra Sudhanshu , Pandey Saumyaa , Selvakumar P. , Srivastava Prateek , T. C. Manjunath
Published: February 2025

AI can enhance supply chain transparency, a critical component of sustainable business practices. In addition to operational improvements, AI fosters innovation in product design and development, allowing businesses to create more sustainable products that meet evolving consumer needs. By analyzing data on consumer preferences and environmental impact, companies can develop products that are not only environmentally friendly but also economically viable. For instance, AI can aid in the design of materials that are more recyclable or biodegradable, reducing the lifecycle impact of products. Furthermore, AI can simulate product performance under various conditions, allowing businesses to refine their designs before production, ultimately reducing waste and resource use. The potential of AI in driving sustainable practices extends beyond individual companies to influence entire industries. Collaborative platforms powered by AI can connect businesses, non-profits, and governments to share best practices, resources, and innovations.
'O Universal pelo Regional'
Authors: Garcia Marcia Monalisa de Morais Sousa , Gussi Alcides Fernando
Published: February 2025

Este artigo tem como objetivo analisar a trajetória histórica da política de internacionalização da Universidade Federal do Ceará (UFC), buscando compreender o processo de instituição de uma política de internacionalização na UFC em diferentes períodos históricos e identificar as políticas e estratégias adotadas pela Administração Superior da UFC ao longo do tempo. Para tanto, fundamentamo-nos nas proposições de Mary Douglas (1998) para compreender processos de institucionalização e na noção de trajetória institucional de uma política, desenvolvida por Gussi (2008). Metodologicamente, foram realizadas pesquisas bibliográficas e análises de documentos produzidos pela Administração Superior. A análise da trajetória histórica da política de internacionalização da UFC revela que o desejo de ser internacional surgiu antes da fundação da Universidade, sendo orientada, contudo, por uma perspectiva euro-norte-centrada e que, ao longo dos anos, a política de internacionalização da UFC foi adquirindo variadas trajetórias em distintas gestões e contextos históricos.
Exploring students’ perceptions of Islamic integration in the clinical nursing education curriculum: a descriptive qualitative study
Authors: Setiowati Dwi , Handayani Maulina
Published: February 2025

The integration of religious and spiritual beliefs into the nursing education curriculum is an effort to build the characteristics of nurses as they become professionals. This study aimed to explore the experiences of nursing students who had undergone Islamic integration. The study employed a descriptive qualitative method, including five clinical nursing students selected through purposive sampling and interviewed online. Three main themes emerged from the data regarding the implementation of Islamic integration in the clinical nursing curriculum. The three themes included challenges in implementation, factors supporting successful implementation, and impact on students. Students face challenges in implementing Islamic integration principles, including resistance to change, limited understanding, and insufficient resources. However, with personal commitment, mentorship, and a supportive environment, successful implementation leads to increased self-awareness, improved ethical decision-making, and enhanced empathy in patient care. Integration requires committed educational effort from all academic staff, which necessitates continuous monitoring, mentoring, and habituation of integration practices as part of an ongoing process. This ensures that the integration of Islamic principles into the nursing curriculum is not only theoretical but also practical and transformative.
Trans in treatment: a mixed-method systematic review on the psychotherapeutic experiences of transgender and gender diverse people
Authors: Mezzalira Selene , Carone Nicola , Bochicchio Vincenzo , Villani Sofia , Cruciani Gianluca , Quintigliano Maria , Scandurra Cristiano
Published: February 2025

Transgender and/or non-binary (TNB) individuals encounter a variety of attitudes from mental healthcare professionals in therapeutic contexts, ranging from microaffirmations to the reinforcement of cis- and heteronormative stereotypes and even overtly invalidating behaviors or communications. Given the scarcity of literature addressing the therapeutic experiences of TNB individuals, the current mixed-method systematic review aimed at better understanding the factors that promote or adversely impact the therapeutic experiences of TNB individuals in clinical contexts. A comprehensive search for relevant records published before August 1, 2024, was conducted across four databases (i.e., Scopus, Web of Science, PubMed, PsycInfo), following PRISMA guidelines. The inclusion criteria specified that only peer-reviewed, indexed, English-language articles addressing the therapeutic experiences of TNB individuals would be selected. A total of 20 studies (both quantitative and qualitative) met these criteria. A meta-synthesis of the selected studies identified three main themes: (1) factors influencing therapist selection and reasons for seeking psychotherapy (e.g., quality of life, gender-specific concerns); (2) factors contributing to a positive therapeutic relationship (a nurturing therapeutic alliance that, e.g., acknowledges authentic gender and addresses intersectional stigma); and (3) factors contributing to negative encounters with mental healthcare providers (e.g., micro- and/or macroaggressions, inadequate trans-specific knowledge, pathologization of TNB identities). Recommendations for future research and clinical practice addressing the needs of TNB individuals in psychotherapy are provided.
T-CELL RECEPTOR (TCR)-VΒ REPERTOIRE FLOW CYTOMETRY FOR T-CELL LYMPHOPROLIFERATIVE DISORDER: A RETROSPECTIVE ANALYSIS OF A SINGLE-CENTER REAL-LIFE LABORATORY EXPERIENCE
Authors: Antonacci Marco , Micozzi Jacopo , Costa Alessandro , Laganà Alessandro , Milani Maria Laura , Intoppa Stefania , Bellomarino Vittorio , Nardacci Maria Grazia , Biglietto Mario , Imperatore Stefano , Bisegna Maria Laura , Martelli Maurizio , Della Starza Irene , De Propris Maria Stefania
Published: February 2025

Background: Discrimination between clonal and reactive cell proliferation is critical for the correct management of T-cell lymphocytosis. Multiparametric flow cytometry (MFC) represents a valuable tool, particularly because it allows to evaluate the T-cell receptor (TCR) Vβ repertoire to pinpoint eventual clonality in T-cell lymphocytosis. A restricted expansion of a single out of the 24 evaluable families or a “clonogram-off” pattern are highly suggestive of the presence of a clonal T-cell population. However, data available on the concordance between MFC TCR-Vβ repertoire and molecular analysis of TCR gene rearrangements, which is regarded as the gold standard for assessing T-cell clonality, are limited.
Objective and methods: We performed a retrospective monocentric study including 307 patients referred to our center for lymphocytosis between 2003 and 2024. The aim of our study was to investigate the diagnostic accuracy of MFC TCR-Vβ repertoire analysis and to compare its performance with molecular analysis of TCR gene rearrangements, for the identification of T-cell clonality.
Results: MFC TCR-Vβ repertoire analysis demonstrated a restricted expansion of a single Vβ family in 67.5% of cases, while clonality in the remaining 32.5% was inferred by a “clonogram-off” pattern.  For 215 (70%) patients both MFC TCR-Vβ repertoire analysis and molecular analysis of TCR gene rearrangements were available, showing an absolute concordance (215 out of 215 cases, 100%) between the two methods. 
Conclusion: MFC TCR-Vβ repertoire analysis is a rapid, cheap, sensitive, and reliable tool to identify clonal T-cell lymphocytosis. It represents an absolute valid first-line diagnostic approach, and it should be included into the routinely laboratory work-up performed MFC analysis for peripheral lymphocytosis.
Successful Management of Steroid-Resistant cutaneous Acute Graft-versus-Host Disease, Toxic Epidermal Necrolysis-Like, with Ruxolitinib
Authors: Ozturk Fahir , Pepeler Mehmet Sezgin , Ucaryilmaz Ozhamam Esra , Korkmaz Gulten
Published: February 2025

A case of Acute graft-versus-host disease (aGVHD)  with severe cutaneous manifestations resembling Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) is presented.
HOW FIRST-LINE THERAPY IS CHANGING IN NON-TRANSPLANT ELIGIBLE MULTIPLE MYELOMA PATIENTS.
Authors: Derudas Daniele
Published: February 2025

Treatment outcomes for patients with multiple myeloma have improved in recent decades thanks to new insights into the biology of the disease and the introduction of new drugs and therapeutic approaches. More than half of patients with multiple myeloma are not eligible for transplantation and for years their treatment has been difficult due to the heterogeneity of this patient group and the lack of treatment options. Recently, attention has focused on the concept of frailty and its quantification in order to adapt the schedule and dosage of treatment to the state of fitness. Modulation of therapy for frailty can reduce side effects and toxicity-related death and define the various successes of therapy. The role of frailty and the development of new tools may provide a way forward to customize the treatment of different patients with multiple myeloma who are not eligible for transplantation. The use of the new association, particularly based on monoclonal antibodies against CD38, showed profound and durable results in terms of progression-free survival and overall survival. Today, these combinations, especially daratumumab-lenalidomide and dexamethasone, represent the “gold standard” of treatment for these patients. The latest quadruplet therapies and cell-directed therapies, including bispecific antibodies and chimeric antigen receptor T-cell (CAR-T) treatment, appear to be very effective and achieve a high rate of negative minimal residual disease. These latter approaches could redefine the population over the age of 65 that is now considered transplant eligible.
Enablers for good governance based on open government initiatives for a South African municipality
Authors: Phahlane Mampilo , Malungana Lario
Published: February 2025

Background: Open government policies, strategic documents and the use of information and communication technology tools are enablers of good governance, which is reflected in citizens’ satisfaction. Despite numerous open government initiatives introduced by various governments worldwide, there is insufficient literature detailing how open government influences governance in a typical municipality.Objectives: The main objective of this research is to investigate the adoption of open government initiatives in a typical South African municipality.Method: This study utilised institutional theory as a lens, as it accurately describes the setting of government, specifically at the municipal level. The researchers chose a purposeful sample of employees from the Buffalo City Metropolitan Municipality and employed an interpretive inductive qualitative case study method to uncover how open government policies and strategic documents facilitate good governance.Results: Data were collected through interviews, and thematic and content analysis were applied to analyse the collected data, uncovering depth and richness. The identified themes emerged from the website, call centres, social media and letters used to communicate with citizens.Conclusion: The study concludes that it is necessary to develop applications to assist government administration and enable citizens to interact in real time through live chats, discussions and online document reviews.Contribution: This study contributes to our understanding of institutional theory, which is inherently complex because of the governmental environment. It particularly focusses on the linkages, networks and couplings between public problems and public jurisdictions, highlighting their high interdependence.
Transition tips: How can we be better leaders as family physicians?
Authors: Van der Bijl Chantelle C. , Nair Arun , Von Pressentin Klaus B.
Published: February 2025

No abstract available.
The moderating effect of environmental dynamism on entrepreneurship and open innovation
Authors: Li Shichao , Zhang Kecheng
Published: February 2025

Background: The effect of entrepreneurship on open innovation under challenging environmental dynamics remains an unresolved issue critical for global economic progress, as the environmental dynamics alter businesses’ capacity for entrepreneurship.Aim: This study aims to examine how entrepreneurship influences open innovation in Chinese companies by investigating the moderating role of environmental dynamism.Setting: A survey questionnaire collected data from 329 middle and senior managers in Shandong, Shanghai, Beijing and other provinces.Method: This study used hierarchical regression analysis as the data analysis method to test the causal relationships and mediating and moderating effects of each hypothesis.Results: It was found that entrepreneurship has a significant positive impact on open innovation in firms. Specifically, entrepreneurial risk-taking and anticipation positively affected open innovation behaviour and strategic orientation of innovation. Moreover, environmental dynamism moderated the relationship between entrepreneurial mechanisms and open innovation.Conclusion: The findings provided new insights into how environmental dynamism shapes the emergence of innovative companies in China. The study suggests entrepreneurs should adjust efforts to promote open innovation behaviour according to the degree of dynamism.Contribution: The study expands and improves the development of the resource-based view and the capability-based view from a theoretical perspective. Furthermore, it broadens the theoretical lens by examining how the strategic orientation of innovation towards entrepreneurship supports open innovation practices to improve the operational performance of organisations. Finally, this research empirically examined the moderating impact of environmental dynamism on the relationship between entrepreneurial strategic orientation and open innovation-based environmental dynamism on company performance.
Transitioning from Industry 4.0 to 5.0: Sustainable supply chain management and talent management insights
Authors: Samuels Alexander B. , Pelser Anna-Marie
Published: February 2025

Orientation: A systematic literature review emphasises the importance of building a resilient and forward-looking industrial sector that can adapt to the evolving demands of Industry 5.0 as it transitions from Industry 4.0. The strategic recommendations from this review underscore the significance of sustainable supply chain management (SSCM) and effective talent management.Research purpose: This study aims to investigate how the transition from Industry 4.0 to Industry 5.0 impacts SSCM and talent management, based on a systematic review and synthesis of existing literature.Motivation for the study: The significance of the study lies in understanding the profound implications of Industry 5.0 on supply chain sustainability and workforce development, particularly in the context of integrating human-centric and sustainable practices with advanced digital technologies.Research approach/design and method: The study employs the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology to conduct a comprehensive systematic review. It synthesises existing literature focussing on the technological advancements, human resource challenges and sustainable practices adopted by industries transitioning from Industry 4.0 to Industry 5.0.Main findings: The study reveals that industries are increasingly integrating advanced technologies such as artificial intelligence (AI), big data analytics and blockchain to improve supply chain efficiency and sustainability. Significant emphasis is placed on reskilling and upskilling the workforce to align with the demands of new technologies and human-centric industrial processes.Practical/managerial implications: The findings highlight the key role of policymakers, industry leaders, and educational institutions in driving the successful adaptation to Industry 5.0. Policymakers must prioritise funding and supportive regulations, while industry leaders need to embrace ongoing upskilling initiatives.Contribution/value-add: The study proposes several strategic recommendations, including the development of inclusive digital infrastructure, encouraging industry collaborations to align educational curricula with market needs and promoting continuous professional development for employees. These recommendations aim to facilitate a resilient and forward-thinking industrial sector capable of meeting the evolving demands of Industry 5.0.
Geloofsontwikkeling: ’n Geloofsreis met roetemerkers
Authors: Greyling Anandie , Nel Malan
Published: February 2025

Faith development: A journey through faith with route markers. The article explores the stage of adolescence and its characteristics, specifically concerning faith formation. It discusses the theological rationale for reaffirming one’s faith at various life transitions and rites of passage, focusing on how it can be implemented during adolescence.Intradisciplinary and/or interdisciplinary implications: This article draws on research regarding ‘roetemerkers’ and the efforts of a task team from the Dutch Reformed church. Furthermore, it forms part of a series of articles based on research within certain Afrikaans Reformed Churches, focusing on children and adolescents’ faith formation.
Toerusting van begeleiers op die geloofsreis
Authors: Hoffman Lyzette
Published: February 2025

Equipping companions on the journey of faith. Faith formation is a multifaceted process involving various role players. Parents, pastors, mentors, catechists, youth leaders, and church board members all play a significant role in a congregation’s faith formation. This article examines the need to equip individuals engaged in this process. The specific roles they undertake will determine the type of training required. Using didache as a foundation, the focus will be on mentoring and serving as role models. Encouraging adults to participate in training presents its own challenges, which can be addressed through a variety of approaches. The research identified key training needs, including the faith development of catechists, an understanding of the lifeworld of children and adolescents (their developmental stages), and the skills required to convey content effectively. Another crucial area of training is koinonia – the building of relationships.Intradisciplinary and/or interdisciplinary implications: Transformative leadership is essential to inspire those involved in faith formation to commit to becoming equipped to achieve excellence in their roles.
Disseminated BCGosis in an infant with mendelian susceptibility to mycobacterial diseases: A case report
Authors: Mena Ganesh Shashank , Rangaswamy Darshan Rajatadri , Kamble Niranjan , Kumar Vikram S
Published: February 2025

Rationale:

Primary immunodeficiency disorders can be fatal especially in infants. Prompt recognition with a comprehensive medical history, genetic evaluation, and appropriate treatment can be lifesaving in a few subtypes.

Patient concerns:

A 4-month-old male infant presented with axillary swelling, fever, and ulcerative lesions. Despite care at multiple facilities, symptoms persisted, raising concern for an underlying immunodeficiency. The patient's sibling had similar symptoms and died at six months, suggesting a genetic predisposition.

Diagnosis:

Mendelian susceptibility to mycobacterial disease, IFNGR2 deficiency.

Interventions:

The patient was treated with tailored anti-tubercular therapy and azithromycin prophylaxis.

Outcomes:

Following treatment, the patient’s symptoms have resolved. At 20 months, he is thriving with normal development.

Lessons:

This case highlights the importance of a thorough medical history and genetic testing in infants with recurrent or unusual infections. Early diagnosis of mendelian susceptibility to mycobacterial disease can lead to effective treatment and better outcomes.
COVID-19 vaccination in patients on biologic or targeted-synthetic disease modifying anti-rheumatic drug therapy: A multi center real-world data
Authors: Yildirim Tuba Demirci , Akleylek Cansu , Yıldırım Derya , Cinakli Haluk , Hakbilen Selda , Coşkun Belkıs Nihan , Okyar Burak , Işık Özlem Özdemir , Sağır Rabia Pişkin , Apaydın Hakan , Karakaş Ali , Erez Yeşim , İnel Tuba Yüce , Gülle Semih , Tufan Abdurrahman , Akar Servet , Yılmaz Sema , Yılmaz Neslihan , Pehlivan Yavuz , Çetin Gözde Yıldırım , Çefle Ayşe , Koca Süleyman Serdar , Erten Şükran , Dalkılıç Ediz , Yazıcı Ayten , Şen Gerçek , Sarı İsmail , Birlik Ahmet Merih , Onen Fatoş
Published: February 2025

Objective:

To assess the effectiveness of COVID-19 vaccination in patients with rheumatic diseases undergoing biologic (bDMARDs) or targeted-synthetic disease-modifying anti-rheumatic drugs (tsDMARDs).

Methods:

This cross-sectional study was conducted at ten rheumatology clinics in Turkey between May 1, 2021, and October 30, 2022. Patients with rheumatic diseases on bDMARD or tsDMARD therapy who received at least two doses of an mRNA or inactivated SARS-CoV-2 vaccine were included. After vaccination, COVID-19 infection rates, adverse events, and rheumatic disease flares were recorded. Data were collected via face-to-face or telephone interviews.

Results:

A total of 963 participants were included in the final analysis; 44% were male, and the median age was 49 years. The most frequently observed rheumatic diseases were ankylosing spondylitis and rheumatoid arthritis, accounting for 37.2% and 32.6% of cases, respectively. Adalimumab (19.2%) and infliximab (17.8%) were the most commonly used bDMARDs. Of the participants, 634 (65.9%) received an inactivated vaccine (CoronaVac) and 329 (34.1%) an mRNA vaccine (BioNTech). A total of 502 (52.1%) patients received a booster dose. Following the first, second, and third vaccine doses, adverse event rates were 19.9%, 15.9%, and 26.7%, respectively. Forty-two (4.4%) patients experienced a disease flare within six months after their first vaccination dose. COVID-19 infection occurred in 79 participants (8.2%) after two vaccine doses; most cases were symptomatic but did not require hospitalization. The COVID-19 infection rate was lower in participants who received a booster dose than those who did not (3.4% vs. 8.2%, P<0.001).

Conclusions:

Our study indicates that both mRNA and inactivated SARS-CoV-2 vaccines are effective in preventing severe COVID-19 outcomes, with an acceptable rate of adverse events and disease flares among patients with rheumatic diseases on bDMARD or tsDMARD therapy.
Antiviral immune responses in human reproductive tract: Pathogenic mechanisms and therapeutic implications
Authors: Chin Kim-Ling , Zainal Nurhafiza
Published: February 2025

Viral reproductive tract infections (VRTIs) are a significant global health concern with severe consequences, including infertility, chronic pelvic pain, and increased risk of HIV transmission. Complex interplay between pathogens and the host immune system plays a critical role in the pathogenesis and treatment of VRTIs. This review aims to provide a comprehensive overview of the multifaceted roles of the immune system in both contributing to and combating VRTIs. The review will also address the consequent perturbations in immune homeostasis and the implications for disease manifestation and progression. The interrelation between systemic immunity and local immune responses is discussed, providing insights into the challenges and breakthroughs in managing these infections. By providing a comprehensive overview of the mechanisms, implications, and therapeutic strategies associated with viral reproductive tract infections and immune dysfunction, this review also informs future research and clinical practice in this important area of reproductive health.
Clinical Study for Validation of Safety and Efficacy of Sharbat Zufa Murakkab in Su‘āl-i-Ratb (Productive Cough) in Eastern India
Authors: Rasheed Abdur , Khan Hakimuddin , Kumar Kishore , Singh Narendra , Zakir Mohammad , Jamali Akhtar Hussain , Siddiqui Ziaul Haq , Saifi Mustehsan
Published: February 2025

Background:

Cough is the most common symptom of respiratory tract disease. It is caused by the mechanical or chemical stimulation of the cough receptors in the epithelium of the pharynx, larynx, trachea, and bronchi. It is an explosive expiration that provides a normal protective mechanism for clearing the tracheobronchial tree of secretions and foreign material. Cough can be initiated by a variety of irritant triggers either from an exogenous source (smoke, dust, fumes foreign bodies, etc.) or from an endogenous origin (upper airway secretions and/or gastric contents).

Aims and Objectives:

The present clinical study was performed to validate the safety and efficacy of Unani Pharmacopoeial formulation “Sharbat Zufa Murakkab” on scientific parameters, in patients of Su‘āl-i-Ratb (productive cough).

Material and Method:

This study was carried out at the Regional Research Institute of Unani Medicine, Bhadrak (Odisha) during the year 2013–2015. A total of 67 patients completed the study out of all registered cases. The treatment duration was of 15 days and the patients of either sex in the age group of 18–65 years were selected for the study with the complaints of cough for more than 3 days associated with expectoration, Khushūna al-Halaq (sore throat), Buhha al-Sawt (hoarseness of voice), and chest tightness.

Result:

Nearly 91% of cases have shown more than 60% relief in signs and symptoms of the disease as compared to baseline. The variations in the values of liver function tests and kidney function tests before and after treatment were found within normal limits.

Conclusion:

The test drug has shown very good results. It was found well tolerated and no adverse effects were observed during the study. The study is asserting the safety and efficacy of “Sharbat Zufa Murakkab” in the treatment of Su‘āl-i-Ratb (productive cough).
Therapeutic Values of Frequently Used Unani Drug Turbud (Operculina turpethum (L.) Silva Manso: A Comprehensive Review
Authors: Ahmad Ishtiyaq , Siddiqui Javed Inam , Alam Abrar , Kazmi Munawwar Husain , Zahid Uzma
Published: February 2025

Plants are always considered for their multidimensional approach from livelihood to medicinal use. Traditional Systems of Medicine including the Unani System of Medicine (USM) have a treasure of important Medicinal plants. Turbud is one of the important Medicinal plants of the USM. The root powder of the drug is used for the treatment of rheumatism, flatulence, paralysis, scorpion sting, snakebite, and skin disorders (such as Vitiligo, eczema, abscesses, acne, scabies, and warts). It is used frequently for Mushil (i.e., therapeutic purgation) in USM. The rhizomes/roots are phlegm-purgative and used for the treatment of phlegmatic and nervous diseases, such as Wajʻal Mafāsil (Arthritis), Irqun Nisa (Sciatica) Niqras (Gout), Fālij (Paralysis) Laqwa (facial palsy), Ḍῑq al-Nafas (bronchial asthma), and Suʻal (cough). The present review comprehensively integrates the pharmacognosy, therapeutic uses, and pharmacology and some evidence-based scientific studies of O. Turpethum related to its efficacy like anti-inflammatory, anticancer, cytotoxic, antisecretory, ulcer protective, hepatoprotective, and antibacterial activities also incorporated.
Creutzfeldt-Jakob disease − A case report
Authors: Negandhi Priyanka , Andhale Amol , Acharya Sourya , Khan Faizan , Patil Tushar
Published: February 2025

Creutzfeldt-Jakob disease (CJD) is a brain disorder that causes dementia. It forms part of a set of animal and human diseases called prion disorders. Symptoms of Creutzfeldt-Jakob disease can resemble those of Alzheimer’s disease. This disease is always fatal, and most patients do not survive beyond a year. Myoclonus, vision problems, brain and pyramidal/extrapyramidal symptoms, and changes in cognitive function and cognitive abilities are seen as manifestations. We present a case of a 65-year-old woman complaining of rapidly progressive dementia, which was followed by the slowness of movements and inability to speak for 3 months. The patient’s family reported jerking of limbs, which was sudden on onset. This case report highlights the differential diagnosis of CJD, which can range from auto-immune diseases, infections, neurodegenerative disorders, metabolic and septic encephalopathies, toxins, ischemia, and drug-induced causes. It helps us to identify and exclude any treatable cause early in the diagnostic process.
Evaluation of Antihyperlipidemic Activity of Leaf Extracts of Rivea hypocrateriformis (Desr.) in High-Fat Diet-Induced Hyperlipidemia Rat Model with Focus on Gene Expression
Authors: Kassab Yaman Walid , Helen Sheeba Devadhasan Aspathi Bai , Gandhimathi Rathinasamy , Searan Wael Mahmoud , Abdalqader Mohammed A. , Kayarohanam Saminathan , Jamal Izzah Zetty Afzan Binti , Janakiraman Ashok Kumar , Janakiram Madhan Kumar Soutallu , Bhupathyraaj Mullaicharam
Published: February 2025

Background: Hyperlipidemia, characterized by a persistent elevation of lipid levels in the bloodstream, serves as a major indicator of cardiovascular risk. Although statin drugs are effective in managing this condition, their use is often accompanied with adverse side effects and drug reactions. Aim and Objective: In light of these limitations, the exploration of herbal and natural remedies for the treatment of hyperlipidemia has gained momentum. This study investigates the antihyperlipidemic potential of Rivea hypocrateriformis (Desr.) in experimental rats subjected to a high-fat diet (HFD)-induced hyperlipidemia model. Methodology: The study examines the potency of hypocrateriformis chloroform extract (HCE) and hypocrateriformis ethanol extract (HEE) of R. hypocrateriformis on the HFD-associated hyperlipidemia in two doses, 100 and 200 mg/kg b.w. The effect of extracts on the changes in body weight, lipid indices and levels, and antioxidant enzymes was measured using standard procedures. Results: HFD-induced hyperlipidemia groups exhibit significant enhancement in all measured parameters among the drug-treated groups. Higher dose normalized the values significantly compared to the standard drug, atorvastatin (20 mg/kg). The results of the antioxidant enzymes showed a significant lowering of oxidative-free radicals and improving antioxidant defense in extract-treated groups. In comparison, HEE showed a significant activity compared to HCE at both doses. Histopathology analysis showed decrease in the size of adipocytes in adipose tissue. This suggests that HEE and HCE may have an inhibitory effect on adipogenesis and could potentially reduce the accumulation of fat in adipose tissue. Conclusion: The current study demonstrated that extracts of R. hypocrateriformis show antihyperlipidemic activity along with known antioxidant and inflammatory mechanisms, opening the scope for future research in developing lead molecules for treating the diseases effectively. Thus, the plant presents itself as a promising candidate which demands future research to improve cardiovascular health and overall life style of the patients.
Countering the Stigma and Misconceptions Associated with Epilepsy
Authors: Shrivastava Saurabh RamBihariLal , Bobhate Prateek Sudhakar , Maulida Anisa Putri , Bardiya Nidhi
Published: February 2025

Epilepsy is a chronic neurological condition that has been reported among people of all ages on the global front. Beyond this physical burden, people with epilepsy are stigmatized and discriminated against, underscoring the need for coordinated interventions to reduce stigma and expand access to healthcare services. Acknowledging the presence of multiple stigma and misconceptions, and the widespread consequences, there is an indispensable need to overcome them through a multipronged approach. In conclusion, epilepsy is a global public health problem and has been associated with multiple stigmas and misconceptions. These issues can be addressed by strengthening awareness campaigns in different settings by involving cultural leaders and leveraging social media to counter myths. In addition, training of healthcare professionals, creating peer support networks, advocating for antidiscrimination policies, and conducting research activities are essential to promote acceptance and improve treatment outcomes.
A systematic review of occupation- and activity-based health management interventions for adult patients with severe mental disorders
Authors: Nasiri Elham , Karbalaei Nouri Ashraf , Hosseini Seyed Ali , Mandani Ghazaleh
Published: February 2025

BACKGROUND:

Considering the negative effects of severe mental disorders (SMDs) on the patient’s social and occupational functioning and general health, besides accumulating evidence on the effectiveness of occupation- and activity-based health management interventions for these patients and the novelty of research on this topic, it is important to review, evaluate, and categorize relevant studies. The present study aimed to systematically review occupation- and activity-based health management interventions for adult patients with SMDs.

MATERIALS AND METHODS:

The present study is a systematic review. We conducted a literature search in Medline, OTseeker, Cochrane Library, Embase, CINAHL, PubMed, PsycINFO, ISI Web of Science, MagIran, ISC, and SID databases from 2000 until October 2021. The study population consisted of patients clinically diagnosed with SMDs (e.g., schizophrenia, bipolar disorder, and major depression). After the literature search, we investigated the screening, quality, and inclusion and exclusion criteria of the articles. In the primary search, we extracted 238 relevant articles, and after appraising their titles and abstracts, we identified 55 relevant articles. After reviewing the full text of the articles and removing duplicates, 17 articles met the inclusion criteria of this study, while we excluded two articles from the quality assessment. Finally, we reviewed 15 studies. The outcomes included all positive and negative treatment effects and outcomes of the interventions.

RESULTS:

According to the results, there were multiple occupation- and activity-based interventions for patients with SMDs, which could directly or indirectly improve their general functioning and health management.

CONCLUSION:

The reviewed studies had numerous blind spots and limitations, such as common shortcomings of randomized clinical trials, lack of long follow-ups, and ambiguity or dispersion of intervention protocols. Besides addressing these limitations, we also discussed research proposals in this study.