bluuebunny/crossref_metadata_2025 huggingface dataset:
Melampsora larici-populina homologous effectors Mlp72983 and Mlp52166 display cell-type specific accumulation in Arabidopsis and Populus
Authors: Gazal Snehi , Gonçalves dos Santos Karen Cristine , Plourde Mélodie B. B. , Levasseur Caroline , Séguin Armand , Tanguay Philippe , Pêtre Benjamin , Germain Hugo
Published: February 2025

Plants interact with microorganisms that can cause diseases and reduce crop productivity. The fungal pathogen Melampsora larici-populina (Mlp) causes the leaf rust disease of poplar trees by secreting proteins, termed effectors, into host tissues to promote pathogenesis. In this study, we functionally characterized two homologous Mlp candidate secreted effector proteins (CSEPs), Mlp72983 and Mlp52166. Confocal microscopy experiments revealed that Mlp72983 has cell type-specific differential localization. It accumulates in the guard cells’ chloroplast of the epidermis and in the nucleus of the spongy mesophyll of Arabidopsis thaliana and Populus alba x Populus tremula. Mlp52166 has a nucleocytosolic accumulation in the epidermal layer and has nuclear localization in the mesophyll layer of the two species. Transcriptomic experiments showed that Mlp72983 and Mlp52166 deregulate plant genes, when constitutively expressed in either Arabidopsis or poplar. The two CSEPs deregulate genes that encode histones, hydroxysteroid dehydrogenases and multidrug and toxic compound extrusion proteins, with roles in DNA repair, methylation, and xenobiotic detoxification. Inoculation assays showed that CSEPs overexpression in poplar transgenics did not enhance susceptibility to rust infection. Despite being closely related in sequence identity, Mlp72983 and Mlp52166 have cell-type specific subcellular localization and deregulate mostly unique sets of plant genes.
Inuit uses of weather, water, ice, and climate indicators to assess travel safety in Arctic Canada, Alaska, and Greenland: a scoping review
Authors: Bishop Breanna , Paquette Emmelie , Carter Natalie , Ljubicic Gita , Oliver Eric C.J. , Aporta Claudio
Published: February 2025

Environmental indicators are naturally occurring variables, conditions, and events that are used to assess and monitor environmental conditions and change. Inuit throughout Inuit Nunaat (Inuit circumpolar homelands) observe and experience environmental indicators as they travel year-round for harvesting and other cultural practices. Inuit draw on their observations of current conditions and their knowledge of weather, water, ice, and climate (WWIC) indicators, when seeking to predict and understand conditions that impact safe travel. This scoping review documents the types and diversity of WWIC indicators articulated in peer-reviewed and grey literature as being used by Inuit in Canada, Alaska, and Greenland to assess travel safety. Two reviewers independently screened 512 studies using pre-determined eligibility criteria and 123 studies were included for review. A total of 163 unique WWIC indicators were used across 85 communities in Canada, Alaska, and Greenland. Indicators reflect a broad range of ways that Inuit experience their environment, through sight, feel, and sound. Indicators can be considered as causal, conditional, or predictive (or a combination thereof), where knowledge of the interactions among various indicators is especially important to support safe travel. Identified gaps and future research directions included assessing key indicators to better target development of locally relevant research and information services.
The impact of compact object deformation on thin accretion disk properties
Authors: Faraji Shokoufe
Published: February 2025

We investigate the standard relativistic geometrically thin and optically thick accretion disk in the background of a deformed compact object. The main purpose of this work is to determine whether such a deformed object possesses its own observational fingerprint that can distinguish it from Schwarzschild and Kerr black holes. Our analysis reveals the properties of this relativistic accretion disk model and its dependence on the initial parameters.
Regression analysis for multiple shape effects on magnetized power law nanofluid flow along a thin needle: An application in targeted drug delivery system
Authors: Sathya Palani , Naveen Padigepati
Published: February 2025

Nowadays, therapeutics mainly depend on drug delivery and magnetic nanofragments in the human body’s circulatory system. The drug particles are infused into the bloodstream with magnetic effects during this treatment, which is normally applied and aids in releasing the medications to the proper organs under magnetic intensity. Numerous medical procedures employ this approach, such as targeted drug delivery, cancer treatments, reduction of excessive bleeding during surgery, the healing process of wounds, and magnetic attraction of blood. However, the nanoparticle’s shape factor causes faster/slower drug release before/after reaching its targeted region. This study strives to investigate the effects of nanoparticle shape on the magnetized power law fluid flow along a thin needle. Additionally, viscous dissipation, suction, and ohmic heating are also considered. The governing equations are transformed with the help of appropriate similarity transformation into a dimensionless form and solved using the Bvp4c technique. The findings reveal that the magnetic field and needle thickness reduce fluid velocity. Further, regression analysis is incorporated to provide further insight into engineering quantities. The platelet-shaped nanoparticle averagely transmits thermal energy an average of [Formula: see text] more than brick, [Formula: see text] more than the blade and [Formula: see text] more than cylinder-shaped nanoparticles.
Topological defects on the q-deformed superstatistics of modified shifted morse potential for carbon monoxide molecule
Authors: Okorie Uduakobong S. , Rampho Gaotsiwe J. , Ramantswana Morris , Ikot Akpan N.
Published: February 2025

The application of topological defects to the study of different molecular potential models has been a focus of interest in recent times due to its significant role in shaping the behavior and interactions of molecular systems. In lieu of this, the asymptotic iteration method is employed to obtain the eigensolutions of the Schrödinger equation of the modified shifted Morse potential model with topological defect. Vibrational energies for carbon monoxide have been presented numerically for various topological defects and the results are compared with experimental data. With the help of the energy expression of modified shifted Morse potential, the q-deformed partition function and other superstatistical function expressions of modified shifted Morse potential for carbon monoxide within the modified Dirac delta distribution are obtained, using the Euler–MacLaurin’s formula. For various temperature values considered, the superstatistical plots show a high level of dependence on the topological defect parameter and deformation parameter. The superstatistical functions for a deformation parameter of zero correspond to the conventional thermodynamic functions. Our results also agree with the available results in the literature.
The effect of cobalt doping on the structure and properties of copper oxide thin films: Evolution in surface morphology, p- to n-type carrier transition and enhancement optoelectronic behavior
Authors: Rahaman Rabeya , Sharmin Mehnaz , Podder Jiban
Published: February 2025

This paper reports the preparation of CuO and cobalt (Co)-doped CuO (Co:CuO) thin films (TFs) by a convenient spray pyrolysis reactor. Co concentration (conc.) was varied in CuO TFs from 2 to 8[Formula: see text]at.% at the step of 2[Formula: see text]at.%. In the FESEM images of undoped films, aggregations of nanoparticles were found. The surface morphology of CuO turned into porous and spongy nanostructures for 6[Formula: see text]at.% Co-doping. In XRD analysis, CuO film showed a monoclinic crystal structure with ([Formula: see text]11) peak occurrence. The crystallite size of the films was found to be between 5[Formula: see text]nm and 12[Formula: see text]nm. In UV–vis spectroscopy, the optical transmittance of Co:CuO films increased in the visible region and then saturated in the NIR light region. The highest transmittance of about 96% was found for the 6 at.% Co:CuO film. The band gap of Co:CuO increased with Co doping. Urbach energy, refractive index, dielectric constants and dispersion energy parameters were estimated. Electrical resistivity and carrier concentration were found in the order of [Formula: see text]-cm and [Formula: see text] [Formula: see text]cm[Formula: see text], respectively. CuO films showed n-type conductivity for 4, 6 and 8[Formula: see text]at.% Co-doping. The figure of merit increased significantly with Co-doping up to 6[Formula: see text]at.%, indicating the enhancement in optoelectronic behavior.
Sol–gel synthesis and UVB luminescence in Sr2P2O7:Gd3+, Ce3+ phosphors for phototherapy applications
Authors: Kherde Nivedita , Nagpure Pankaj Ambadasji , Dhale Shruti Prabhakar , Kshetrapal Supriya Manish , Ugemuge Nilesh Sureshrao , Omanwar Shreeniwas K.
Published: February 2025

In this study, a series of Gd[Formula: see text], Ce[Formula: see text] doped Sr2P2O7 phosphors synthesized by a novel method utilizing stearic acid sol–gel are reported. Structural analysis performed by X-ray diffraction (XRD) pattern revealed that doping of trivalent lanthanide ions did not change the orthorhombic structure possessed by Sr2P2O7 matrix and also confirmed the phase purity and crystallinity of the phosphor. Scanning electron microscopy (SEM) micrograph confirms its surface morphology and particle size in the range of 50[Formula: see text]nm to [Formula: see text]m. Photoluminescence (PL) studies revealed that PL emission for Gd[Formula: see text] and Ce[Formula: see text]-doped Sr2P2O7phosphor gives significant emissions which are suitable for application in UV-LEDs for phototherapy portable devices.
Link prediction in complex networks based on resource transition capacity and local paths
Authors: Pan Xiaohui , Xu Guiqiong , Dong Chen
Published: February 2025

Link prediction aims to identify missing links within static networks or estimate the probability of emerging links in dynamic networks, representing a critical and challenging research direction in complex network. Many similarity-based methods have been established from various viewpoints, however, there are relatively few methods that take into account both the path information between node pairs and the nodes along the path. To fill this gap, we propose two novel link prediction algorithms, namely LPRA and LPH. The core idea is that the similarity between node pairs is closely related to the local paths connecting the two nodes and the resource transition capability of the nodes along those paths. The algorithms utilize the local paths with adjustable lengths between node pairs and the topological information of the nodes on the path to calculate the similarity index, which incorporate the resource transition capabilities of all the nodes on the possible paths between node pairs. We conducted multiple groups of comparative experiments on 10 real-world networks to validate the effectiveness of the proposed algorithm. Experimental results demonstrate that LPRA and LPH outperform nine classical methods and five recently popular methods. Moreover, LPRA demonstrates a significant difference level (P-value [Formula: see text]) compared to most of the methods in the ANOVA of AUC accuracy, indicating a statistically significant performance advantage of LPRA.
Speed of Adjustment of Trade Receivables: The Case of a Developing Country
Authors: Nguyen Liem
Published: February 2025

Examining the mean reversion behavior and the adjustment speed of trade receivables of nonfinancial listed firms in Vietnam from 2010 to 2022, this is the first study to investigate whether firms feature a tendency to move toward target trade credit level, and how COVID-19 influences trade credit supply in a dynamic setting in a developing market. The research results suggest that firms do have a target trade receivables level and the speed of adjustment toward this target level is quite significant. Further, we show that firms demonstrate a faster adjustment speed toward target trade credit receivables during the COVID-19 pandemic. We show that lower profitability and higher allowance for bad trade receivables can positively affect the adjustment speed. As the COVID-19 pandemic tends to affect profitability and the level of bad trade receivables, we consider these factors as channels that explain why firms tend to adjust faster toward their target trade credit during the pandemic. The study offers implications for achieving sustainable development and improving business performance.
Methane Production via Al4C3 Electrodeposition from CO2 at an Al Electrode/NaCl-CaCl2 Melt Interface
Authors: Fukuhara Hijiri , Suzuki Yuta , Tanaka Seiya , Goto Takuya
Published: February 2025

This study proposes a new process for methane production from CO2 and H2O via Al4C3 formation by electrochemical reduction of CO2-derived CO3
2− ions on an Al electrode in NaCl-CaCl2-CaO melt at 873 K. The electrodeposited Al4C3 can generate methane through a spontaneous chemical reaction with water. The proposed process was demonstrated by electrochemical measurements, X-ray diffraction, thermodynamic evaluation, and quantitative analysis of the gas generated by the reaction between the Al4C3 and water. The effects of applied potential, electrolytic time, and additives into the melt on the current efficiency of methane were investigated. It was found that methane was obtained with a maximum current efficiency of 63 ± 2.5% when potentiostatic electrolysis was performed at 0.45 V for 5 min in the melt containing 6.0 mol% Al4C3 under CO2 atmosphere, although that was less than 10% in the system without Al4C3. The addition of Al4C3 before electrolysis prevented the dissolution of the electrodeposited Al4C3 into the melt. Based on the results, the formation mechanism of Al4C3 on the Al electrode is discussed. The novel process of methane synthesis doesn’t need reducing agents, such as hydrogen. It is also possible to obtain CO2-derived methane when needed by storing methane sources as solid Al4C3.
A Case of Chondroblastoma in the Medial Condyle of the Femur Treated With an Intra‐Articular Approach via the Intercondylar Fossa
Authors: Fumoto Masato , Mori Tomoaki , Mizuma Tsuyoshi , Kamio Satoshi , Yamaguchi Sayaka , Asano Naofumi , Kobayashi Shu , Nakayama Robert
Published: February 2025

Adequate bone curettage is crucial for treating epiphyseal chondroblastomas. However, achieving adequate curettage while minimizing damage to the articular cartilage is challenging. For lesions at the center of the distal femoral epiphysis, curettage using an intercondylar approach may have better oncological and functional outcomes than the conventional extra‐articular approach from the wall of the epiphysis. We herein present a case of a 22‐year‐old male patient with a chondroblastoma of the femoral medial condyle close to the intercondylar fossa. Intercondylar curettage was performed at the site of the insertion of the posterior cruciate ligament (PCL). Maximal knee flexion allowed for good exposure of the lesion, and a direct approach to the tumor led to adequate curettage. Careful suturing of the PCL and postoperative care resulted in sufficient joint stability. The patient showed no signs of local recurrence or osteoarthritic changes at his 16‐month follow‐up. The intercondylar approach could be a surgical technique worth considering for the treatment of chondroblastoma in the distal femoral epiphysis, particularly for lesions located near the intercondylar fossa.
Transcatheter Aortic Valve Replacement in Patients With Quadricuspid Aortic Valve: A Case Series and Systematic Review
Authors: Sheng Wenjing , Zhou Dao , Dai Hanyi , Zheng Rongrong , Aihemaiti Ailifeire , Liu Xianbao
Published: February 2025

Background: Quadricuspid aortic valve (QAV) is a rare congenital cardiac anomaly associated with symptomatic aortic regurgitation (AR) or aortic stenosis (AS). Transcatheter aortic valve replacement (TAVR) for QAV remains uncertain.

Methods: We retrospectively reviewed prospectively collected data from patients with QAV undergoing TAVR in our center and conducted a systematic literature review for further investigation.

Results: Five patients with QAV were treated with TAVR between April 2016 and December 2023. The median age was 67 years (range: 59–86), and the median Society of Thoracic Surgeons score (STS‐score) was 3.750% (range: 0.916%–11.823%). Procedural success was achieved in all cases. The median follow‐up period was 3 years (from 30 days to 7 years). Four of the patients exhibited no serious complications, while one experienced delayed coronary obstruction. Our systematic review included 31 cases from 21 publications and our center. The median age of patients was 79 years (range: 57–90), including 18 males. The median STS score was 7.835%. Severe AS was present in 64.5% of the patients and severe AR in 41.9%. The most common QAV subtype was type B (48.4%). Technical success was achieved in 100% of the cases, with two cases reporting coronary obstruction and one required a permanent pacemaker implantation. During a median follow‐up period of 1 year (from 30 days to 7 years), one case experienced serious complications of delayed coronary obstruction.

Conclusion: The TAVR may be an alternative treatment for patients with QAV, preliminarily demonstrating feasible early and long‐term results from current experience. However, extra precautions regarding coronary artery obstruction complications are necessary due to the rarity and anatomical complexity of QAV.
Ureteral Haemangiosarcoma in a Dog: Rare Primary Tumour With Unusual Metastasis to the Contralateral Kidney
Authors: Żebrowski Kacper , Kandefer-Gola Małgorzata , Bujok Jolanta , Borawski Wojciech , Dzimira Stanisław
Published: February 2025

A dog (neutered male, 11 years old, Labrador retriever) underwent abdominal ultrasound, which revealed a 7 cm diameter tumour (caudal region of the left kidney). The animal showed symptoms of weight loss, apathy, haematuria, and abdominal pain. A computed tomography (CT) scan confirmed the presence of a tumour originating from the ureter. Following surgery to remove the ureter with the attached kidney, a histopathological examination was performed. The tumour was classified as a haemangiosarcoma. After the initial recovery, 2 months after surgery, the dog was diagnosed with a tumour in the other kidney. A fine needle biopsy was carried out. A haemangiosarcoma metastasis was suspected. Neoplasms of the ureter are a rare pathology. This is the first case in which metastasis to the second kidney has been confirmed.
Treatment of Melasma With Q‐Switched Laser in Combination With Tranexamic Acid
Authors: Liu Zirui
Published: February 2025

Melasma, a pigmentary disorder that particularly affects Asian women, has been clinically proven to respond effectively to combination therapy of Q‐switched lasers and tranexamic acid (TXA), especially with the advancements in laser aesthetics in recent years. However, treatment outcomes can be influenced by factors such as the wavelength and spot size of the Q‐switched laser, the route of administration for TXA (including injectable, oral, or topical), as well as the dosage and duration of treatment. This article presents 13 different combination approaches from six randomized controlled trials, indicating that oral administration of TXA in combination with a 1064 nm Q‐switched laser is currently the most widely used and effective treatment approach.
Unraveling the Resistome, Virulome, and Pathogenicity of Escherichia Coli O157:H7 From Cattle Feces
Authors: Oluwarinde Bukola Opeyemi , Ajose Daniel Jesuwenu , Abolarinwa Tesleem Olatunde , Montso Peter Kotsoana , Njom Henry Akum , Ateba Collins Njie
Published: February 2025

Antimicrobial‐resistant Escherichia coli, especially those belonging to the serotype O157, are increasingly linked to foodborne diseases with significant fatality rates worldwide. The food and medical industries have focused on E. coli O157:H7 due to its ability to produce toxins coupled with its low infectious dose. The aim of this study was to assess the virulome, resistome, and pathogenicity of E. coli O157:H7 using whole genome sequencing. Three previously isolated E. coli O157:H7 strains from cattle feces were subjected to whole genome sequencing. The genome sizes of all three E. coli O157:H7 strains were 5,117,276 bp, 5,039,443 bp, and 5,034,351 bp. The C + G contents were 50.22%, 50.53%, and 50.54%, while the number of contigs was 110, 43, and 42, respectively, for E. coli O157:H7 strains J32, J57, and J69. Several virulence determinants (hemorrhagic E. coli pilus (HCP), eaeA, hemolysin, etc.) were found in the genomes of these isolates. In addition, antibiotic resistance genes conferring resistance to aminoglycosides, tetracyclines, macrolides, fluoroquinolones, penams, carbapenems, cephalosporins, cephamycin, rifamycin, phenicols, monobactams, and nitroimidazole were found in the genomes. Interestingly, the genomes of these isolates also harbored determinants encoding resistance to disinfectants and antiseptics, indicating their concern in the food production and medical sectors. This highlights the public health concerns of these isolates, indicating the need for constant surveillance.
Predicting Oil Temperature in Electrical Transformers Using Neural Hierarchical Interpolation
Authors: Boujamza Abdeltif , Lissane Elhaq Saâd
Published: February 2025

Effective electricity consumption planning is critical for power distribution. Ensuring the distribution network aligns with expected demand fluctuations is a challenging task influenced by various time‐related and seasonal variables. This study focuses on improving transformer oil temperature forecasting, an indicator of transformer health, using the neural hierarchical interpolation for time series (NHITS) model. The NHITS model’s architecture is designed to handle long‐term forecasting efficiently, making it ideal for capturing extended trends in transformer oil temperature. It incorporates multirate signal sampling via MaxPool layers and hierarchical interpolation to merge predictions across different time scales. The proposed methodology involves two key phases: data preparation and model development. In the data preparation phase, the electricity transformer temperature (ETT) datasets are used, normalized with a standard scaler, and essential features such as oil temperature and external power load are selected. During the model development phase, the proposed NHITS model is trained and its hyperparameters are optimized for optimal performance. The study evaluates the model’s performance under various conditions, including the comparison of multivariate and univariate time series, the effects of short and long‐term forecasting horizons, and the impact of temporal resolution. The model was validated using the ETT dataset, and our results were benchmarked against a previous study that employed the same dataset and used the Informer model. The results indicate that the NHITS model outperforms the Informer model, showing an average decrease of 51.37% in mean squared error (MSE) and 37.83% in mean absolute error (MAE). These findings highlight the model’s ability to capture both long‐term and short‐term characteristics of time series data, making it a promising solution for forecasting transformer oil temperatures.
Evaluation of Metabolites and Biological Activities of Areca Nut (Areca catechu L.) Under Different pH: Untargeted Mass Spectrometry–Based Metabolomics Approach
Authors: Zhang Jing , Dai Jiahui , Wang Shiping , Rui Kai , Dai Wenting , Kang Xiaoning , Ji Jianbang , Wang Weizhong
Published: February 2025

Chewing areca nuts (ANs) produces a mild sense of excitement and happiness, particularly under alkaline conditions. To identify the substances responsible for these effects, we conducted a nontargeted metabolomics analysis comparing AN metabolites at different pH levels. Subsequently, AN’s active components were determined, and the in vitro antioxidant activities were evaluated. The results showed that pH affected the expression of flavonoid and isoflavonoid biosynthesis pathways, leading to changes in flavonoid, alkaloid, and organic acid levels. Alkaline conditions facilitated the hydrolysis of arecoline and guvacoline to arecaidine and guvacine, respectively. Twenty‐eight alkaloids were identified as AN metabolites, of which 22 are reported for the first time. Among these, arecoline, arecaidine, scopolamine, and theobromine may be responsible for the excitatory effects of AN. The active component content and antioxidant activity of AN were significantly influenced by pH. The antioxidant activity of AN was highest at pH 12, which might be another reason AN consumer products require alkaline conditions. The excitatory effects of AN under alkaline conditions are likely owing to the combined effects of various active ingredients. In conclusion, we clarified the effect of pH on the composition and activity of AN and determined the biochemical basis of the excitatory effect of AN. These findings provide theoretical guidance for further development and utilization of active AN functions.
Transition of Adolescents With Diabetes Mellitus to Adult Care at the Ho Teaching Hospital in Ghana
Authors: Nukpezah Ruth Nimota , Tsigbe Cyril Charles
Published: February 2025

Background: Transitioning adolescents with diabetes from pediatric to adult care poses significant challenges, especially in low‐resource settings like Ghana. Poorly coordinated transitions can disrupt care continuity and adversely impact health outcomes.

Objective: This study explored how adolescents with diabetes mellitus (DM) transition from pediatric to adult care at Ho Teaching Hospital, Ghana.

Methods: A qualitative exploratory‐descriptive design was used. Semistructured interviews were conducted with 15 adolescents and their caregivers. Thematic analysis was applied to identify key themes and subthemes.

Findings: Six key themes emerged: (1) inadequate education on DM management, with gaps in adolescents’ and caregivers’ understanding of the disease and emergency symptoms; (2) limited self‐management skills, with caregivers performing most care tasks; (3) poor timing and uncoordinated transfer, with abrupt transitions at age 13; (4) overreliance on caregivers, as caregivers were hesitant to shift responsibilities to adolescents; (5) limited adolescent involvement in care decisions, with healthcare providers engaging more with caregivers; and (6) recommendations for transition improvement, including raising the transfer age, providing skills training, and establishing a transition clinic.

Conclusion: The study underscores the need for a structured, developmentally appropriate transition process with targeted education, skills training, and adolescent participation to promote self‐management and improve transition outcomes for adolescents with DM.
Seismic Fragility Assessment of Steel Rigid‐Frame Bridges Exposed to Marine Corrosion
Authors: Rahai Alireza , Zabetian Shahrzad , Rashedi Seyed Hadi
Published: February 2025

Corrosion is one of the main concerns in different industrial sectors, leading to millions of dollars lost every year worldwide. Hence, the study of deterioration due to corrosion and its effects on the seismic performance of steel structures, especially those located in corrosive regions, is essential. In the present study, the influence of marine corrosion has been considered to reduce the section area of the bridge’s immersion piers using Melchers’s corrosion model. Several models of corroded steel rigid‐frame (CSRF) bridges have been made, and nonlinear static analysis (pushover) and nonlinear incremental dynamic analysis (IDA) have been done on corroded bridge models to estimate capacity loss and predict seismic fragility at certain times during their service life. To validate the nonlinear analysis method, the experimental and numerical results are compared. The analysis results indicate that the bridge’s capacity and energy dissipation under a corrosive environment have been considerably decreased, and the probability of collapse has increased. After 90 years of the structure’s service life, the results of the seismic evaluation of the behavior of steel bridges in severe corrosive environments show that the bridge’s base shear has decreased by 33%, and the probability of collapse has increased by 15%. Based on the results of this study, some recommendations and strategies have also been suggested for the seismic design of new bridges and the rehabilitation of existing bridges in corrosive areas.
Endothelial cell pY397-FAK expression predicts risk of breast cancer recurrences after radiotherapy in SweBCG91-RT cohort
Authors: Drake Rebecca J .G. , Landén Amalia H. , Holmberg Erik , Stenmark Tullberg Axel , Killander Fredrika , Niméus Emma , Jordan Alexander , McGuinness Jennifer , Karlsson Per , Hodivala-Dilke Kairbaan
Published: February 2025

PURPOSE: Identifying biomarkers of radiotherapy (RT) response is important for optimising the treatment of early breast cancer (BC). Here we tested the interaction between endothelial cell (EC) expression of phospho-Tyr397-FAK (pY397-FAK) and adjuvant-RT on clinical outcomes after breast-conserving surgery (BCS) within a randomised study. Preclinical data suggests an enhanced effect of RT with low EC_ pY397-FAK expression. METHODS: We analysed tissue microarrays (TMAs) from the SweBCG91-RT (stage I-II, lymph node-negative) BC cohort, consisting of 1,178 patients randomly assigned to receive either BCS alone or BCS plus adjuvant-RT. TMA sections were immunostained for pY397-FAK, CD31, α-smooth-muscle-actin (αSMA) and pan-cytokeratin (panCK). HALO analysis scored mean pY397-FAK intensity in CD31+ ECs, panCK+ tumour epithelial cells (TCs) and αSMA+ mural/stromal cells per core. For 822 patients, multivariable Cox regression analysis was performed for the primary and secondary 5-year endpoints, locoregional recurrence (LRR) and ‘all recurrence’, respectively, as dependent variables, and RT and EC_pY397-FAK as independent variables. RESULTS: EC_ pY397-FAK expression was not predictive for the primary endpoint, LRR (p=0.098), but the direction of the RT effect was in line with preclinical findings. For the secondary endpoint, all recurrence, there was a significant interaction (p=0.026) between EC_ pY397-FAK and RT. Without RT, higher EC_ pY397-FAK expression resulted in lower risk for all recurrence (HR 0.74 per SD, CI 95% 0.57-0.96, p=0.026). CONCLUSION: Within the first 5-years post-BCS, patients with low EC_pY397-FAK expression derive greater benefit from RT than patients with high EC_pY397-FAK expression. However, without RT low EC_pY397-FAK expression is associated with a higher risk of recurrence.
Supplementary Table 2 from The Selective WEE1 Inhibitor Azenosertib Shows Synergistic Antitumor Activity with KRASG12C Inhibitors in Preclinical Models
Authors: Jameson Nathan M. , Kim Daehwan , Lee Catherine , Skrable Blake , Shea Alexandra , Guo Xiao , Izadi Hooman , Abed Mona , Harismendy Olivier , Ma Jianhui , Kim Doris S. , Lackner Mark R.
Published: February 2025

TP53 status and pathogenicity for each model utilized for this study. Mutation status was derived from DepMap (https://depmap.org/portal/) for cell lines or provided by the PDX CRO.
Supplementary Figure 7 from The Selective WEE1 Inhibitor Azenosertib Shows Synergistic Antitumor Activity with KRASG12C Inhibitors in Preclinical Models
Authors: Jameson Nathan M. , Kim Daehwan , Lee Catherine , Skrable Blake , Shea Alexandra , Guo Xiao , Izadi Hooman , Abed Mona , Harismendy Olivier , Ma Jianhui , Kim Doris S. , Lackner Mark R.
Published: February 2025

Combination of azenosertib With KRASG12C inhibitors in vivo increases median survival in NSCLC models sensitive to KRASG12C inhibition
Supplementary Figure 1 from The Selective WEE1 Inhibitor Azenosertib Shows Synergistic Antitumor Activity with KRASG12C Inhibitors in Preclinical Models
Authors: Jameson Nathan M. , Kim Daehwan , Lee Catherine , Skrable Blake , Shea Alexandra , Guo Xiao , Izadi Hooman , Abed Mona , Harismendy Olivier , Ma Jianhui , Kim Doris S. , Lackner Mark R.
Published: February 2025

Combination of azenosertib and KRASG12C inhibitors demonstrates synergy in NSCLC in 2D in vitro cellular assays by Bliss Independence model.
Figure 5 from The Selective WEE1 Inhibitor Azenosertib Shows Synergistic Antitumor Activity with KRASG12C Inhibitors in Preclinical Models
Authors: Jameson Nathan M. , Kim Daehwan , Lee Catherine , Skrable Blake , Shea Alexandra , Guo Xiao , Izadi Hooman , Abed Mona , Harismendy Olivier , Ma Jianhui , Kim Doris S. , Lackner Mark R.
Published: February 2025

Combination of azenosertib with KRASG12C inhibitors in vivo increases the depth and duration of TGI in NSCLC models sensitive to KRASG12C inhibition. A, Mean tumor volume ± SEM of subcutaneous NCI-H2030 xenografts in NOD/SCID mice (n = 9/group). Azenosertib and sotorasib monotherapy arms ended on days 18 and 27, respectively. Combination groups remained on-treatment until day 67. P < 0.0001 for all comparisons with vehicle; P < 0.0001 for combinations compared with azenosertib monotherapy at day 18; P < 0.0001 for combinations compared with sotorasib monotherapy at day 26. B, Mean tumor volume ± SEM of subcutaneous NCI-H1792 xenografts in NOD/SCID mice (n = 9/group). Azenosertib monotherapy and adagrasib 50 mg/kg monotherapy and combination arms were treated for 32 days. Adagrasib 100 mg/kg monotherapy and combination arms continued dosing until day 53, and then animals were monitored off-treatment until day 71 or 102. P < 0.0001 for comparison of azenosertib with vehicle; P < 0.0001 for combinations and adagrasib monotherapy compared with azenosertib monotherapy at day 32. C, Individual animal tumor volumes on day 71 or 102 for adagrasib monotherapy (red) and combination (purple) from B. Two animals in the 100 mg/kg adagrasib monotherapy group and three animals in the 100 mg/kg adagrasib combination group were removed before day 102 because of thymoma development unrelated to treatment.
A Randomized Controlled Crossover Trial to Determine the Effects of Three Nostril Regulated Breathing Practices on Attention and Mood
Authors: Gandharva Kumar , Sharma Sachin Kumar , Balkrishna Acharya , Telles Shirley
Published: February 2025

Background: Previous studies on nostril regulated breathing have contrasting findings attributed to lack of controls or not taking into account baseline nostril patency. This randomized crossover study on the effects of three nostril regulated yoga breathing practices and two controls on mood states and attention attempted to address these issues.
Materials and methods: Forty-five participants between 20 and 45 years (group mean age ± SD; 24.3±3.8 years; M;F 23:22) were assessed in five sessions in random order on five separate days. Nostril patency recorded pre-interventions in 225 sessions showed right nostril dominant at rest (RNDR) in 136 and left nostril dominant at rest (LNDR) in 89 sessions. The sessions were: (i) SAV or right uninostril breathing, (ii) CAV or left unnostril breathing, (iii) (AV or alternate nostril yoga breathing, (iv) breath awareness (BAW), and (v) quiet seated rest (QS). The practices were for 15 min each. Nostril patency was recorded pre, Brief mood introspection scale (BMIS), Global Vigor and Affect Scale (GVA) and Six letter cancellation test (SLCT) were recorded pre and post each session. Data analysis used general linear mixed model analysis, with fixed effects of states (pre and post), sessions and baseline nostril dominance (right or left).
Results: A significant interaction of sessions, states and nostril dominance at baseline was observed for total global affect (GA) (F9,396.194=2.871, p=0.003) which increased after SAV, CAV, AV and QS in participants right nostril dominant at rest (NDR) (padj<0.05 in all cases). A significant main effect of states was observed followed by significant post-hoc pair wise comparison in right NDR for (i) pleasant mood after SAV, CAV, AV and QS, (ii) positive mood after SAV and AV, and (iii) global vigor after SAV, CAV, AV and QS, and (iv) a decrease in negative mood after CAV and AV. While the volunteers who had left NDR showed a significant increase in (i) PU after CAV, AV, and QR, (ii) PT after CAV, and (iii) GV after CAV and QS.
Conclusion: Nostril dominance pre intervention appears to influence the effects of nostril regulated yoga breathing practices.
Role of Odorant-Binding Protein in Allergy to Cow Epithelium.
Authors: González Guzmán Luis Alfredo , González Fernández Cristina Susana , Castromil-Benito Estela Soraya , Gómez-Caballerob Nerea , Pastor-Vargas Carlos , Boquete Paris Manuel , González Francisco Carballada
Published: February 2025

Background: In a previous study conducted by the Allergy Section of the HULA, sensitization to an undescribed 25 kDa protein was detected in patients allergic to cow epithelium. Mass spectrometry identified the protein as an Odorant-binding protein (OBP), a lipocalin from Bos taurus. Although its association with symptoms has not been proven, recent research suggests that its inclusion in extracts for diagnosis and treatment could be beneficial. Objective: To evaluate the role of odorant-binding protein (OBP) in cow epithelium allergy (CEA) in sensitized patients. Material and methods: Descriptive, cross-sectional, observational study of a case series, including a total of 17 patients with confirmed sensitization to cow allergens by immunoblotting. From this cohort, seven participants were selected for further analysis. Data collected included age, sex, occupation, years of exposure, test results, and the group classification to which each participant belonged. OBP was purified and isolated from bull urine, and a lyophilized extract was prepared for skin testing and conjunctival provocation. Results: Skin prick tests with purified OBP were positive in six of seven patients with bovine epithelium allergy. Conjunctival allergen provocation tests (CAPT) were positive in four out of six patients. All controls were negative in both tests. Conclusions: Odorant-binding protein behaves as a major antigen in this cohort of CEA patients. This is the first study to establish the independent clinical relevance of bovine odorant-binding protein (OBP) in cow epithelium allergy, paving the way for improved diagnostic and therapeutic protocols.
Into the Here and Now: Explorations within a New Acoustic Virtual Reality
Authors: Cliffe Laurence
Published: February 2025

The author reflects upon listeners’ experiences and the practice of developing a number of audio-augmented reality sound installations deployed between 2019 and 2020. The installations realized audio-augmented objects: physical real-world objects augmented with virtual audio content. Focusing on users’ feedback from one such installation environment, the author suggests that audio-augmented objects are capable of realizing virtual audio experiences that are indistinguishable from reality, offering the potential for the development of new and exciting auditory experiences that embed virtual audio content within listeners’ physical environments.
The Defining Role of Spatial Immersive Technologies in the Creation of the Electroacoustic Compositions Moments of Liberty I–IV
Authors: Savva Dimitrios
Published: February 2025

This article focuses on how recording, playback, and compositional spatial immersive technologies play a defining role in creating 8-channel electroacoustic compositions Moments of Liberty I–IV. Drawing from the author’s doctoral research, the article specifically explores the application of these technologies and techniques in the production of the primary sound material, its recording, and the spatial processing and articulation employed primarily to achieve a heightened sense of spatial immersion, and secondarily to enhance dramatization and musical flow.
A Relational Look at Interactions between Humans and Nonhuman Organisms in Interactive Art
Authors: Xu Dan , Lamers Maarten H. , Van Der Heide Edwin , Verbeek Fons J.
Published: February 2025

Interactive art is evolving towards a more-than-human perspective, embracing the significance and opportunities of involving nonhuman participants. This raises questions about the forms and types of interactions applied in such artworks. To capture and analyze interactions facilitated by interspecies artworks, the authors apply a relational model that they originally developed for describing human co-located interaction. By uncovering patterns in the roles of human and nonhuman elements within these artworks, the authors demonstrate that the relational model is effective not only in analyzing such interactions but also in proposing novel roles for future more-than-human interactive art.
Cost and Its Determinants of Treating Type 2 Diabetes Mellitus in the North West Region of Cameroon: Quantile Regression Analysis
Authors: Cholong Bereynuy , Aloysius Njong
Published: February 2025

Background: Type 2 Diabetes Mellitus (T2DM) is, particularly, known to require continuous clinical care and management that consumes significant healthcare resources. As a result, most people living with type 2 Diabetes in Cameroon, are prone to suffer from financial hardship. This research seeks to estimate the direct cost and its determinants of treating T2DM in the Northwest of Cameroon. METHOD: A cost of illness using a cross-sectional research design study was conducted in 13 facilities in Cameroon’s Northwest region during a 4-month field survey. Data was obtained with the help of a semi-structured questionnaire administered by trained nurses. Summary statistics were computed to understand the socio-demographic characteristics of participants, and the various elements of treatment costs of type 2 diabetes. The direct cost of treating type 2 diabetes was computed by summing all the diabetes-attributable resource utilization costs incurred by the patient The determinants for treating T2DM were investigated using an ordinary least squares (OLS) regression and a quantile regression analysis. RESULTS: According to the findings, the average cost of treating type 2 diabetes among patients in the Northwest region of Cameroon, was 36,235 FCFA ($60) monthly or 424,000 FCFA ($720) yearly. The determinants were; the type of facility which was significant for the 10th and 25th quintiles, and age influence cost across the various models and quantiles, the study also revealed the effect of age on the cost increase from the lower to the higher quintile. The level of education influenced the direct cost and this was significant from the 50th quintile to the 90th quintile with higher levels of education leading to higher costs. Other factors included the household head, frequency of check-up visits to the facility, self-care management, and means of transportation. Gender and marital status influence cost but not across the quintiles. CONCLUSION: The studies revealed that T2DM places a significant cost burden on the patient and their household with determinants being the type of facility where care is sorted, age, level of education, and means of transport. Increased financial resources are required to provide T2DM patients with effective services in the Northwest region of Cameroon. A sincere call is sent to health decision-makers to give more importance to including diabetes care in the package of universal health coverage soonest.
Analysis of Studies on Interpreter’s Role on International Journals by Citespace (2000-2022)
Authors: Wang Hairuo
Published: February 2025

Interpreters play important roles in international communication, and the international research on interpreter’s role has a history of over 50 years. This study use Citespace tool to analyse the data of Web of Science from 2000 to 2022 in order to understand the status quo and trend of research. It is found that such research saw a general trend of increase in fluctuation and there seems to be lack of cooperative research with much room for future cooperation between different research institutions. Current research can be categorized into conference interpreting, medical interpreting, court interpreting, prison interpreting, community interpreting, sign language interpreting, telephone interpreting, etc. It can also be classified into professional and non-professional interpreting, self-perspective and others ’ perspective, interpreting practice, interpreting quality, interpreting history, professional and inter professional education, etc. Future research could further the traditional domains and integrate the research with other domains of interpreting studies and that of other sectors. It could be further combined with sociological theories, adopt more diversified research methods, take a broader view in terms of interpreter’s working environment, and combine more closely with technology.
Reciprocity, trust and conflict: Volunteers and refugees in rural Germany
Authors: Wagner Greta
Published: February 2025

The refugees who arrived in Germany in 2015 and 2016 were largely housed in village communities where people did not previously have extensive exposure to cultural diversity. This article focuses on the relationships between refugees and the volunteers who support them as they arrive in their new communities, which were examined over a long-term period based on qualitative data. It also examines the role of perceptions of reciprocity and conflict resolution between volunteers and refugees in fostering trust. When relationships are perceived as reciprocal, trust develops; when reciprocity is blocked or denied, mistrust emerges. In addition, when conflicts are addressed in a productive manner, trust can be repaired or even strengthened. Since the sociological literature on trust usually assumes that it flourishes where there is no conflict, this is a surprising finding. The article illustrates on a micro-level what might be a valuable perspective on pluralistic societies in general: The integrative role of conflict.
Contextual factors impacting families in enabling resilience of gender and sexually diverse youth
Authors: Zhange Mthandeki , Mohangi Kamleshie
Published: February 2025

Family affirmation is an important factor in the psychological adjustment and resilience of LGBTQ+ youth. However, owing to hetero-cisnormative discourses in most rural communities, Gender and sexually diverse youth thrive through the most devastating adversities while negotiating for their LGBTQ+ identity in families. To understand systemic factors within and beyond family that influence the capacity of families to affirm LGBTQ+ youth, this article draws on data from a PhD study. This article presents qualitative interpretive phenomenological results from research involving 12 participants identifying as LGBTQ+ youth from a rural community in the Free State province. Participants were selected using nonprobability purposive and snowball sampling methods. The article explores factors that influence families to affirm their children with gender and sexual diversities, thereby highlighting the utility of ecological interventions that extend beyond working with a nuclear family to champion its resilience. The article also explores tensions that shape affirmation and marginalisation within a family context. It also demonstrates how risk exposure in families is perpetuated by multiple intersecting variables, such as family religious beliefs and cultural ideals that encourage heterosexuality and cisgender expression. Moreover, it shows the family’s openness and adaptive role in fostering the resilience of LGBTQ+ youth despite the prevalent hetero-cisnormative discourses. Despite the influence of the identified systemic factors, some families still navigate the affirmation of gender and sexual diversity. To this end, the article gives useful insights for practice and future research.