bluuebunny/crossref_metadata_2025 huggingface dataset:
Development and Validation of a Nausea Severity Scale for Assessment of Nausea in Children with Abdominal Pain-Related Functional Gastrointestinal Disorders
Authors: Russell Alexandra C. , Stone Amanda L. , Wang Andi , Walker Lynn S.
Published: June 2018

The objective of this study was to develop a pediatric measure of chronic nausea severity, the Nausea Severity Scale (NSS), and evaluate its reliability and validity in youth with abdominal pain-related functional gastrointestinal disorders (AP-FGID). Pediatric patients (aged 11–17 years-old, n = 236) presenting to an outpatient clinic for evaluation of abdominal pain completed the NSS, Children’s Somatization Inventory (CSI), Functional Disability Inventory (FDI), Abdominal Pain Index (API), Patient-Report Outcomes Measurement Information System (PROMIS), Anxiety and Depression Scales and the Pediatric Rome III Questionnaire for FGIDs. The NSS demonstrated good concurrent, discriminant, and construct validity, as well as good internal consistency. One-third (34%) of AP-FGID patients reported experiencing nausea “most” or “every day” in the previous two weeks. The severity of nausea was higher in females than males and correlated significantly with the severity of somatic symptoms, functional disability, anxiety, and depression. The NSS is a valid and reliable measure of nausea in children with AP-FGID.
Preparation and Photoluminescence of Tungsten Disulfide Monolayer
Authors: Lv Yanfei , Huang Feng , Zhang Luxi , Weng Jiaxin , Zhao Shichao , Ji Zhenguo
Published: May 2018

Tungsten disulfide (WS2) monolayer is a direct band gap semiconductor. The growth of WS2 monolayer hinders the progress of its investigation. In this paper, we prepared the WS2 monolayer through chemical vapor transport deposition. This method makes it easier for the growth of WS2 monolayer through the heterogeneous nucleation-and-growth process. The crystal defects introduced by the heterogeneous nucleation could promote the photoluminescence (PL) emission. We observed the strong photoluminescence emission in the WS2 monolayer, as well as thermal quenching, and the PL energy redshift as the temperature increases. We attribute the thermal quenching to the energy or charge transfer of the excitons. The redshift is related to the dipole moment of WS2.
Treatment of Major Depressive Disorder in Pediatric Populations
Authors: Neavin Drew R. , Joyce Jeremiah , Swintak Cosima
Published: June 2018

Major depressive disorder (MDD) is a severe illness that afflicts about 16.6% of people over their lifetime. MDD is highly correlated with suicidality, and often first presents in adolescence. Unfortunately, many pediatric patients suffering from MDD go undiagnosed, and current evidence-based treatment options in the U.S. are limited to psychotherapy and two selective serotonin reuptake inhibitors approved by the United States Food and Drug Administration. Molecular mechanisms have been shown to play a role in MDD pathogenesis, progression, and response to medication, yet few studies have explored the role of these pathways in pediatric MDD. In this review, we outline the gravity and importance of MDD in pediatric patients, some challenges in diagnosis and treatment, current treatments available for pediatric patients, and research to investigate differences between pediatric and adult MDD. We hope that this review will provide an outline of the current understanding and treatment of MDD in pediatric patients, and provide thoughtful insights for future work that could advance our understanding of MDD in pediatric populations, and also identify new therapeutic strategies.
Top Incomes and Inequality Measurement: A Comparative Analysis of Correction Methods Using the EU SILC Data
Authors: Hlasny Vladimir , Verme Paolo
Published: June 2018

It is sometimes observed and frequently assumed that top incomes in household surveys worldwide are poorly measured and that this problem biases the measurement of income inequality. This paper tests this assumption and compares the performance of reweighting and replacing methods designed to correct inequality measures for top-income biases generated by data issues such as unit or item non-response. Results for the European Union’s Statistics on Income and Living Conditions survey indicate that survey response probabilities are negatively associated with income and bias the measurement of inequality downward. Correcting for this bias with reweighting, the Gini coefficient for Europe is revised upwards by 3.7 percentage points. Similar results are reached with replacing of top incomes using values from the Pareto distribution when the cut point for the analysis is below the 95th percentile. For higher cut points, results with replacing are inconsistent suggesting that popular parametric distributions do not mimic real data well at the very top of the income distribution.
The Index Number Problem with DEA: Insights from European University Efficiency Data
Authors: Klumpp Matthias
Published: June 2018

An increasing effort has been put into dealing with the question of time-series analysis regarding institutional efficiency, including in the area of higher education. Universities are important institutions for economies and societies and are expected to provide excellence as well as efficiency in their processes and outputs. This is reflected in the context of an increased global competitive environment by more refined international university rankings. Combining the two areas, this paper points towards a methodological challenge in comparing different ranking datasets for their use in a data envelopment analysis (DEA) Malmquist index time-series efficiency analysis, namely, index-based data compared to additive data. The problem is discussed in a theoretical framework and complemented with an empirical application: calculations for 70 European universities with budget and staff input data and different ranking output data for the timeframe of 2011–2016 show that there is no evidence for a specific index data problem. Important implications regarding university management and higher education policies are outlined. Efficiency improvements among the analyzed universities are significant but also unevenly distributed and not easy to obtain for individual institutions.
Real-Time Ventricular Fibrillation Detection Using an Embedded Microcontroller in a Pervasive Environment
Authors: Kwon Sundeok , Kim Jungyoon , Chu Chao-Hsien
Published: June 2018

Many healthcare problems are life threatening and need real-time detection to improve patient safety. Heart attack or ventricular fibrillation (VF) is a common problem worldwide. Most previous research on VF detection has used ECG devices to capture data and sent to other higher performance units for processing and has relied on domain experts and/or sophisticated algorithms for detection. In this case, it delayed the response time and consumed much more energy of the ECG module. In this study, we propose a prototype that an embedded microcontroller where an ECG sensor is used to capture, filter and process data, run VF detection algorithms, and only transmit the detected event to the smartphone for alert and call for services. We discuss how to adapt a common filtering and scale process and five light-weighted algorithms from open literature to realize the idea. We also develop an integrated prototype, which emulates the VF process from existing data sets, to evaluate the detection capability of the framework and algorithms. Our results show that (1) TD outperforms the other four algorithms considered with sensitivity reaching 96.56% and specificity reaching 81.53% in the MIT-BIH dataset. Our evaluations confirm that with some adaptation the conventional filtering process and detection algorithms can be efficiently deployed in a microcontroller with good detection accuracy while saving battery power, shortening response time, and conserving the network bandwidth.
A Control Methodology for Load Sharing System Restoration in Islanded DC Micro Grid with Faulty Communication Links
Authors: Shahid Muhammad Umair , Khan Muhammad Mansoor , Hashmi Khurram , Habib Salman , Jiang Huawei , Tang Houjun
Published: June 2018

Communication-based distributed secondary control is extensively used in DC microgrids. Compared to centralized control, it can provide better voltage regulation and load sharing in microgrids. A conventional secondary control technique that converges the system to a common operating point is improved by using the control methodology to detect the communication link failure and stabilize the system operation during communication islanding. Recently, more robust control schemes have been proposed to improve resilience, but communication islanding has not been addressed at the secondary level control for which the system requires additional tertiary control. However, link failure is a possibility in the microgrid, so this paper proposes a control scheme at the secondary level to detect communication islanding. Communication islanding may lead the system to unpredictable behavior, which may cause the system to become unstable and may further lead to a cascading failure. The proposed control scheme sustains the stability and operation of a DC microgrid. Voltage and current observer works in a parallel manner with the proposed secondary control to achieve a correction term for global operating points. The proposed control scheme has been verified through analysis and simulation.
Design, Analysis, and Evaluation of a Compact Electromagnetic Energy Harvester from Water Flow for Remote Sensors
Authors: Wang Tao , Zhang Yunce
Published: June 2018

This paper develops an electromagnetic energy harvester, which can generate small-scale electricity from non-directional water flow in oceans or rivers for remote sensors. The energy harvester integrates a Tesla disk turbine, a miniature axial-flux permanent magnet generator, and a ring cover with symmetrical grooves which are utilized to rectify flow direction. A compact structure is achieved by mounting the permanent magnets of the generator directly on the end surfaces of the turbine rotor. Theoretical analysis is implemented to illustrate the energy conversion process between flow kinetic form and electrical form. Additionally, a mathematical model is developed to investigate the magnetic field distribution produced by the cubical permanent magnets as well as parametric effect. Plastic prototypes with a diameter of 65 mm and a height of 46 mm are fabricated by using a 3D printing technique. The effect of the groove angle is experimentally investigated and compared under a no-load condition. The prototype with the optimal groove angle can operate at flow velocity down to 0.61 m/s and can induce peak-to-peak electromotive force of 2.64–11.92 V at flow velocity of 0.61–1.87 m/s. It can be observed from the results that the analytical and the measured curves are in good accordance. Loaded experiments show that the output electrical power is 23.1 mW at flow velocity of 1.87 m/s when the load resistance is approximately equal to the coil resistance. The advantages and disadvantages of the proposed energy harvester are presented through comparison with existing similar devices.
Comparative Investigation of Hybrid Excitation Flux Switching Machines
Authors: Du Yi , Lu Wei , Wang Qi , Zhu Xiaoyong , Quan Li
Published: June 2018

In this paper, the effect of partitioned stator (PS) structure and iron flux bridges in hybrid excitation flux switching (HEFS) machines is comprehensively discussed and compared. Firstly, the operating principles of four HEFS machines with single stator and PS respectively with and without iron flux bridges are described. Then an equivalent lumped parameter magnetic circuit model is developed to analyze the characteristics of PS structure and iron flux bridges. In order to achieve a fair comparison among different HEFS machines, the multi-level design optimization method is used to obtain the optimal parameters efficiently, based on which the electromagnetic performances of four machines are comprehensively evaluated by using 2D finite element analysis (2D-FEA). The results reveal that the machines with PS structure can exhibit not only a better flux regulation capability but also a higher torque density than conventional HEFS machines. Moreover, by adopting iron flux bridges, enlarged wide constant power speed region (CPSR) can be achieved, but the PM utilization will be slightly sacrificed.
An Adaptive Frequency Strategy for Variable Speed Wind Turbines: Application to High Wind Integration Into Power Systems
Authors: Fernández-Guillamón Ana , Villena-Lapaz Jorge , Vigueras-Rodríguez Antonio , García-Sánchez Tania , Molina-García Ángel
Published: June 2018

This paper presents a new frequency controller for variable speed wind turbines connected to the grid under power imbalance conditions. It is based on the fast power reserve emulation technique, having two different operation modes: overproduction and recovery mode. In the first mode, the active power provided by wind turbines is set over the mechanical power, reducing their rotational speed. This overproduction power is estimated according to the frequency excursion. In the second mode, the active power is established under the mechanical power to recover the initial rotational speed through a smooth trajectory. The power system considered for simulation purposes includes thermal, hydro-power and wind-power plants. The controller proposed has been evaluated under different mix-generation scenarios implemented in Matlab/Simulink. Extensive results and comparison to previous proposals are also included in the paper.
Impeller Optimized Design of the Centrifugal Pump: A Numerical and Experimental Investigation
Authors: Han Xiangdong , Kang Yong , Li Deng , Zhao Weiguo
Published: June 2018

Combined numerical simulation with experiment, blade wrap angle, and blade exit angle are varied to investigate the optimized design of the impeller of centrifugal pump. Blade wrap angles are 122°, 126°, and 130°. Blade exit angles are 24°, 26°, and 28°. Based on numerical simulation, internal flow of the centrifugal pump with five different impellers under 0.6, 0.8, 1.0, 1.2, and 1.5 Qd are simulated. Variations of static pressure, relative velocity, streamline, and turbulent kinetic energy are analyzed. The impeller with blade wrap angle 126° and blade exit angle 24° are optimal. Distribution of static pressure is the most uniform and relative velocity sudden changes do not exist. Streamlines are the smoothest. Distribution scope of turbulent kinetic energy is the smallest. Based on performance experiments, head and efficiency of the centrifugal pump with the best impeller are tested. The values of head and efficiency are higher than that of the original pump. Centrifugal pump with the best impeller has better hydraulic performance than the original centrifugal pump.
The Effect of Unbalanced Impedance Loads on the Short-Circuit Current
Authors: Kim Insu
Published: June 2018

Conventional short-circuit studies often neglect the load current because the short-circuit current (SCC) flowing from generators is much greater than the SCC that is affected by various loading conditions. As distributed or clustered loads that are unbalanced in phases are connected to the grid, they can also change the magnitude and phase angle of the SCC, despite their small capacities. Thus, the objective of this study is to present algorithms that are able to analyze such an impedance unbalanced load. For this purpose, this study initially derives an SCC model of the unbalanced impedance load in phases. Since the proposed SCC model requires the pre-fault voltage, it uses a power-flow analysis algorithm that iteratively calculates the current that is to be injected and the pre-fault voltage, using the bus impedance matrix. Then, the proposed SCC calculation algorithm transforms the unbalanced loads into equivalent impedances, using the pre-fault voltage, and adds them to sequence networks as input data, using the proposed SCC model. The proposed algorithms are verified in various case studies. As a result, the proposed SCC calculation algorithms are more accurate, because they do not neglect unbalanced loads.
Investigation of Water Hammer Protection in Water Supply Pipeline Systems Using an Intelligent Self-Controlled Surge Tank
Authors: Wan Wuyi , Zhang Boran
Published: June 2018

A surge tank is a common pressure control device in long pressurized pipelines. The performance is greatly influenced by the location, cross area, and the characteristics of the connector. In order to improve the property of the surge tank, the effect of the connector is numerically analyzed by the method of characteristics (MOC). A hysteretic effect can occur when the discharge capacity is limited. Therefore, the performance of the surge tank can be improved if the discharge capacity of the connector is appropriately controlled according to the different conditions. For the adjustability of the connector’s discharge capacity, a kind of intelligent self-controlled surge tank (IST) is proposed. In addition, through simulations and analysis, IST is proved to have advantages in pressure control and applicability compared to normal surge tanks.
Design of a Path-Tracking Steering Controller for Autonomous Vehicles
Authors: Sun Chuanyang , Zhang Xin , Xi Lihe , Tian Ying
Published: June 2018

This paper presents a linearization method for the vehicle and tire models under the model predictive control (MPC) scheme, and proposes a linear model-based MPC path-tracking steering controller for autonomous vehicles. The steering controller is designed to minimize lateral path-tracking deviation at high speeds. The vehicle model is linearized by a sequence of supposed steering angles, which are obtained by assuming the vehicle can reach the desired path at the end of the MPC prediction horizon and stay in a steady-state condition. The lateral force of the front tire is directly used as the control input of the model, and the rear tire’s lateral force is linearized by an equivalent cornering stiffness. The course-direction deviation, which is the angle between the velocity vector and the path heading, is chosen as a control reference state. The linearization model is validated through the simulation, and the results show high prediction accuracy even in regions of large steering angle. This steering controller is tested through simulations on the CarSim-Simulink platform (R2013b, MathWorks, Natick, MA, USA), showing the improved performance of the present controller at high speeds.
Renewable Energy, Ecology and Environment to Arabic Pupils Using a Creative, “Hands On” Approach
Authors: Friman Hen , Sitbon Yafa , Banner Ifaa , Shauli Tal , Einav Yulia
Published: June 2018

An action learning course is an academic course which involves academic learning and social activities, and has an impact on the community. In the last year, students from the HIT, Holon Institute of Technology, participated in the action learning course “Green Ambassador”, which aimed to teach pupils about renewable energy and preserving an environment. As part of the course requirements, students were asked to conduct enjoyable lessons for fifth and sixth grade pupils in the Arabic elementary school “Alomaria” situated in the city of Ramle. During lessons held within the school, the students taught the pupils via games and activities what is soil contamination, how to turn waste into a resource, what is an air pollution, energy conversion and etc. In order to illustrate the topics studied by the pupils, the students used a moveable laboratory containing demonstrations, experiments and creative activities. Thus, active participation of the pupils in the lessons was achieved. The results show higher rates of success in the final questionnaires on the lessons’ topics and involvement, due to an enriching and a challenging experience of learning. Thanks to the action learning course, the pupils became more aware and learned an important lesson about the ways to preserve the environment.
Improved Estimates of Biomass Expansion Factors for Russian Forests
Authors: Schepaschenko Dmitry , Moltchanova Elena , Shvidenko Anatoly , Blyshchyk Volodymyr , Dmitriev Egor , Martynenko Olga , See Linda , Kraxner Florian
Published: June 2018

Biomass structure is an important feature of terrestrial vegetation. The parameters of forest biomass structure are important for forest monitoring, biomass modelling and the optimal utilization and management of forests. In this paper, we used the most comprehensive database of sample plots available to build a set of multi-dimensional regression models that describe the proportion of different live biomass fractions (i.e., the stem, branches, foliage, roots) of forest stands as a function of average stand age, density (relative stocking) and site quality for forests of the major tree species of northern Eurasia. Bootstrapping was used to determine the accuracy of the estimates and also provides the associated uncertainties in these estimates. The species-specific mean percentage errors were then calculated between the sample plot data and the model estimates, resulting in overall relative errors in the regression model of −0.6%, −1.0% and 11.6% for biomass conversion and expansion factor (BCEF), biomass expansion factor (BEF), and root-to-shoot ratio respectively. The equations were then applied to data obtained from the Russian State Forest Register (SFR) and a map of forest cover to produce spatially distributed estimators of biomass conversion and expansion factors and root-to-shoot ratios for Russian forests. The equations and the resulting maps can be used to convert growing stock volume to the components of both above-ground and below-ground live biomass. The new live biomass conversion factors can be used in different applications, in particular to substitute those that are currently used by Russia in national reporting to the UNFCCC (United Nations Framework Convention on Climate Change) and the FAO FRA (Food and Agriculture Organization’s Forest Resource Assessment), among others.
Improved Prediction of Stream Flow Based on Updating Land Cover Maps with Remotely Sensed Forest Change Detection
Authors: Hernandez Alexander J. , Healey Sean P. , Huang Hongsheng , Ramsey R. Douglas
Published: June 2018

The water balance in a watershed can be disrupted by forest disturbances such as harvests and fires. Techniques to accurately and efficiently map forest cover changes due to disturbance are evolving quickly, and it is of interest to ask how useful maps of different types of disturbances over time can be in the prediction of water yield. We assessed the benefits of using land cover maps produced at annual vs. five-year intervals in the prediction of monthly streamflows across 10 watersheds contained entirely within the US National Forest System. We found that annually updating land cover maps with forest disturbance data significantly improved water yield predictions using the Soil and Water Assessment Tool (SWAT; p < 0.01 improvement for both the Nash–Sutcliffe efficiency measure and the ratio of the root mean square error to the standard deviation of the measured data). Improvement related to using annually updated land cover maps was directly related to the amount of disturbance observed in a watershed. Our results lay a foundation to apply new high-resolution disturbance datasets in the field of hydrologic modeling to monitor ungauged watersheds and to explore potential water yield changes in watersheds if climate conditions or management practices were to change forest disturbance processes.
Effects of a Heat Wave on Nocturnal Stomatal Conductance in Eucalyptus camaldulensis
Authors: Resco de Dios Víctor , Loik Michael E. , Smith Renee A. , Tissue David T.
Published: June 2018

Nocturnal transpiration constitutes a significant yet poorly understood component of the global water cycle. Modeling nocturnal transpiration has been complicated by recent findings showing that stomata respond differently to environmental drivers over day- vs. night-time periods. Here, we propose that nocturnal stomatal conductance depends on antecedent daytime conditions. We tested this hypothesis across six genotypes of Eucalyptus camaldulensis Dehnh. growing under different CO2 concentrations (ambient vs. elevated) and exposed to contrasting temperatures (ambient vs. heat wave) for four days prior to the night of measurements, when all plants experienced ambient temperature conditions. We observed significant effects after the heat wave that led to 36% reductions in nocturnal stomatal conductance. The response was partly driven by changes in daytime stomatal behavior but additional factors may have come into play. We also observed significant differences in response to the heat wave across genotypes, likely driven by local adaptation to their climate of origin, but CO2 played no effect. Stomatal models may need to incorporate the role of antecedent effects to improve projections particularly after drastic changes in the environment such as heat waves.
Dynamic Patterns of Trees Species in Miombo Forest and Management Perspectives for Sustainable Production—Case Study in Huambo Province, Angola
Authors: Chiteculo Vasco , Surovy Peter
Published: June 2018

This paper aims to assess important forest parameters, including tree density, diameter at breast height (DBH), and age distribution, investigate the dynamic growth of miombo tree species, and employ this information to design a management framework in miombo forests. The delineation of the management zones was based on unsupervised land cover classification that began with three zones where ground data was collected and increased to five zones. Eighteen circular plots (25.2 m radius) were randomly distributed over the study areas to assess the current situation and potential growth patterns for each species. The patterns of the six most representative tree species of miombo in Angola were described and we used KORFiT 2.4 software to fit data and develop growth curves for at least three miombo species. Growth function fitness was evaluated by root mean squared error (RMSE), coefficient of determination (R2), significance of the parameters (p < 0.05), and Akaike’s information criterion (AIC). The diameter distribution of miombo tree species resembled a typical distribution of uneven-aged forest stands; higher DBH classes had lower abundances of tree species. Logistic and Gompertz growth functions were the best fits for miombo tree species. Brachystegia spiciformis Benth., is suggested as a potential species for timber management in the region because they displayed high growth potential to more quickly reach an assumed minimum DBH of 20 cm. This study concluded that miombo forest stands present an irregular structure in which DBH distribution illustrated only two patterns: many small stems and a bimodal forest structure.
Effects of Vegetation Management on Wood Properties and Plant Water Relations of Four Conifer Species in the Pacific Northwest of the USA
Authors: Aernouts Joyce , Gonzalez-Benecke Carlos A. , Schimleck Laurence R.
Published: June 2018

In plantation forests, competition from unwanted vegetation may reduce survival and negatively impact tree growth. The goal of this study was to examine the influence of vegetation management treatments on plant water relations and wood properties. Control trees (no treatment) were compared to trees subjected to post-planting competing vegetation control for five consecutive years after planting. Four conifer species (Douglas-fir, western hemlock, western redcedar, and grand fir) were studied on two different sites in western Oregon, USA. Carbon isotope (13C) analysis was used to study intrinsic water use efficiency (iWUE) and X-ray densitometry was used to measure specific gravity, ring width, and latewood percent. We found a significant interaction between vegetation management treatment and wood ring (growing season) in iWUE for Douglas-fir. There was little effect of vegetation management treatment on ring specific gravity for all species. Only western redcedar growing at a central Coast Range site showed increased ring specific gravity under sustained competing vegetation control. When growing under conditions of sustained control of competing vegetation, western redcedar at a central Coast Range site had a significant increase in earlywood specific gravity, while Douglas-fir at a Cascade Foothills site had a significant decrease in latewood specific gravity. Western redcedar and grand fir had a significant interaction-effect on its latewood percentage, with treatment trees having a higher latewood percentage than control trees after ring 8. Further, Douglas-fir and western hemlock had a significant increase in ring, earlywood, and latewood area with treatment, and grand fir had a significant interaction-effect of treatment × ring for ring, earlywood, and latewood area. This study indicates that, for conifer trees growing under sustained vegetation control, growth gains could be achieved without compromising wood properties. However, if harvested at a target diameter, these trees will have a larger proportion of low quality corewood compared to trees from conventionally managed stands.
The Complete Mitochondrial Genome of Glyptothorax macromaculatus Provides a Well-Resolved Molecular Phylogeny of the Chinese Sisorid Catfishes
Authors: Lv Yunyun , Li Yanping , Ruan Zhiqiang , Bian Chao , You Xinxin , Yang Junxing , Jiang Wansheng , Shi Qiong
Published: June 2018

Previous phylogenetic analyses of the Chinese sisorid catfishes have either been poorly resolved or have not included all the 12 sisorid genera. Here, we successfully assembled the first complete mitochondrial genome of the sisorid fish Glyptothorax macromaculatus. Based on this novel mitochondrial genome and previously published mitochondrial genomes in the Sisoridae, we generated maximum likelihood and Bayesian phylogenies. We dated our preferred topology using fossil calibration points. We also tested the protein-coding genes in the mitochondrial genomes of the glyptosternoid fishes for signals of natural selection by comparing the nucleotide substitution rate along the branch ancestral to the glyptosternoid fishes to other branches in our topology. The mitochondrial sequence structure of G. macromaculatus was similar to those known from other vertebrates, with some slight differences. Our sisorid phylogenies were well-resolved and well-supported, with exact congruence between the different phylogenetic methods. This robust phylogeny clarified the relationships among the Chinese sisorid genera and strongly supported the division of the family into three main clades. Interestingly, the glyptosternoid divergence time predicted by our molecular dating analysis coincided with the uplift of the Tibetan Plateau, suggesting that geology may have influenced speciation in the Sisoridae. Among the mitochondrial protein-coding genes, atp8 may have most rapidly evolved, and atp6 may have been subjected to positive selection pressure to adapt to high elevations. In summary, this study provided novel insights into the phylogeny, evolution and high-altitude adaptions of the Chinese sisorid fishes.
The Arts as a Medium for Care and Self-Care in Dementia: Arguments and Evidence
Authors: Schneider Justine
Published: June 2018

The growing prevalence of dementia, combined with an absence of effective pharmacological treatments, highlights the potential of psychosocial interventions to alleviate the effects of dementia and enhance quality of life. With reference to a manifesto from the researcher network Interdem, this paper shows how arts activities correspond to its definition of psycho-social care. It presents key dimensions that help to define different arts activities in this context, and illustrates the arts with reference to three major approaches that can be viewed online; visual art, music and dance. It goes on to discuss the features of each of these arts activities, and to present relevant evidence from systematic reviews on the arts in dementia in general. Developing the analysis into a template for differentiating arts interventions in dementia, the paper goes on to discuss implications for future research and for the uptake of the arts by people with dementia as a means to self-care.
Factors Contributing to the Duration of Chemotherapy-Induced Severe Oral Mucositis in Oncopediatric Patients
Authors: Damascena Lecidamia Cristina Leite , De Lucena Nyellisonn Nando Nóbrega , Ribeiro Isabella Lima Arrais , De Araujo Tarciana Liberal Pereira , De Castro Ricardo Dias , Bonan Paulo Rogério Ferreti , Lima Neto Eufrásio de Andrade , De Araújo Filho Luiz Medeiros , Valença Ana Maria Gondim
Published: June 2018

This study analyzes the factors contributing to the duration of severe oral mucositis in oncopediatric patients. A longitudinal study was conducted in the pediatric department of a cancer referral hospital between 2013 and 2017. Seventy-three patients diagnosed with cancer undergoing chemotherapy protocols were analyzed. Oral evaluations were performed using the Modified Oral Assessment Guide criteria, and the data were collected from the patients’ records. The Kaplan-Meier method was used to estimate survival curves. Most patients were males (52.1%), of mixed race (“pardo”) (49.3%), with a mean age of 7.56 years (±5.34). There was a predominance of patients diagnosed with solid tumors (52.1%), with no metastasis (86.3%), using natural product chemotherapeutics (56.2%), who had not undergone a bone marrow transplant (97.3%); amputation was observed in 35.6% of patients, while death rates were as high as 8.2%. The survival analysis estimated a mean time of 30.6 days until complete remission of severe oral mucositis. The regression analysis showed that patients over 10 years old had a median mucositis duration 1.4 times greater than those at the age of 10 years or younger. Patients without metastasis had a median mucositis duration 1.7 times greater than those with metastasis (p-value ≤ 0.10). Increasing age and the absence of metastasis were conditions that prolonged the duration of severe oral mucositis.
Effect of Intermittent Energy Restriction on Flow Mediated Dilatation, a Measure of Endothelial Function: A Short Report
Authors: Headland Michelle L. , Clifton Peter M. , Keogh Jennifer B.
Published: June 2018

Intermittent energy restriction is a popular alternative to daily energy restriction for weight loss; however, it is unknown if endothelial function, a risk factor for cardiovascular disease, is altered by periods of severe energy restriction. The objective of the study was to determine the impact of two consecutive very low energy intake days, which is the core component of the 5:2 intermittent energy restriction diet strategy, on endothelial function compared to consecutive ad libitum eating days. The secondary objective was to explore the effects of these dietary conditions on fasting glucose concentrations. This was a 4-week randomized, single-blinded, crossover study of 35 participants. Participants consumed a very low energy diet (500 calories for women, 600 calories for men) on two consecutive days per week and 5 days of habitual eating. In weeks 3 and 4 of the trial, participants had measurements of flow mediated dilatation (FMD) and blood samples taken following either 2 habitual eating days or 2 energy restricted days in a randomized order. FMD values were not different after the two eating states (8.6% vs. 8.3%, p = 0.7). All other outcome variables were unchanged. Endothelial function, as measured by flow mediated dilatation, was not altered by two consecutive very low energy intake days. Further investigations assessing the impact in specific population groups as well as different testing conditions would be beneficial.
A Moment-Based Shape Similarity Measurement for Areal Entities in Geographical Vector Data
Authors: Fu Zhongliang , Fan Liang , Yu Zhiqiang , Zhou Kaichun
Published: May 2018

Shape similarity measurement model is often used to solve shape-matching problems in geospatial data matching. It is widely used in geospatial data integration, conflation, updating and quality assessment. Many shape similarity measurements apply only to simple polygons. However, areal entities can be represented either by simple polygons, holed polygons or multipolygons in geospatial data. This paper proposes a new shape similarity measurement model that can be used for all kinds of polygons. In this method, convex hulls of polygons are used to extract boundary features of entities and local moment invariants are calculated to extract overall shape features of entities. Combined with convex hull and local moment invariants, polygons can be represented by convex hull moment invariant curves. Then, a shape descriptor is obtained by applying fast Fourier transform to convex hull moment invariant curves, and shape similarity between areal entities is measured by the shape descriptor. Through similarity measurement experiments of different lakes in multiple representations and matching experiments between two urban area datasets, results showed that the method could distinguish areal entities even if they are represented by different kinds of polygons.
4D Time Density of Trajectories: Discovering Spatiotemporal Patterns in Movement Data
Authors: Zou Yebin , Chen Yijin , He Jing , Pang Gehu , Zhang Kaixuan
Published: June 2018

Modern positioning and sensor technology enable the acquisition of movement positions and attributes on an unprecedented scale. Therefore, a large amount of trajectory data can be used to analyze various movement phenomena. In cartography, a common way to visualize and explore trajectory data is to use the 3D cube (e.g., space-time cube), where trajectories are presented as a tilted 3D polyline. As larger movement datasets become available, this type of display can easily become confusing and illegible. In addition, movement datasets are often unprecedentedly massive, high-dimensional, and complex (e.g., implicit spatial and temporal relations and interactions), making it challenging to explore and analyze the spatiotemporal movement patterns in space. In this paper, we propose 4D time density as a visualization method for identifying and analyzing spatiotemporal movement patterns in large trajectory datasets. The movement range of the objects is regarded as a 3D geographical space, into which the fourth dimension, 4D time density, is incorporated. The 4D time density is derived by modeling the movement path and velocity separately. We present a time density algorithm, and demonstrate it on the simulated trajectory and a real dataset representing the movement data of aircrafts in the Hong Kong International and the Macau International Airports. Finally, we consider wider applications and further developments of time density.
Effects of Cyclic Mechanical Stretch on the Proliferation of L6 Myoblasts and Its Mechanisms: PI3K/Akt and MAPK Signal Pathways Regulated by IGF-1 Receptor
Authors: Fu Shaoting , Yin Lijun , Lin Xiaojing , Lu Jianqiang , Wang Xiaohui
Published: June 2018

Myoblast proliferation is crucial to skeletal muscle hypertrophy and regeneration. Our previous study indicated that mechanical stretch altered the proliferation of C2C12 myoblasts, associated with insulin growth factor 1 (IGF-1)-mediated phosphoinositide 3-kinase (PI3K)/Akt (also known as protein kinase B) and mitogen-activated protein kinase (MAPK) pathways through IGF-1 receptor (IGF-1R). The purpose of this study was to explore the same stretches on the proliferation of L6 myoblasts and its association with IGF-1-regulated PI3K/Akt and MAPK activations. L6 myoblasts were divided into three groups: control, 15% stretch, and 20% stretch. Stretches were achieved using FlexCell Strain Unit. Cell proliferation and IGF-1 concentration were detected by CCK8 and ELISA, respectively. IGF-1R expression, and expressions and activities of PI3K, Akt, and MAPKs (including extracellular signal-regulated kinases 1 and 2 (ERK1/2) and p38) were determined by Western blot. We found that 15% stretch promoted, while 20% stretch inhibited L6 myoblast proliferation. A 15% stretch increased IGF-1R level, although had no effect on IGF-1 secretion of L6 myoblasts, and PI3K/Akt and ERK1/2 (not p38) inhibitors attenuated 15% stretch-induced pro-proliferation. Exogenous IGF-1 reversed 20% stretch-induced anti-proliferation, accompanied with increases in IGF-1R level as well as PI3K/Akt and MAPK (ERK1/2 and p38) activations. In conclusion, stretch regulated L6 myoblasts proliferation, which may be mediated by the changes in PI3K/Akt and MAPK activations regulated by IGF-1R, despite no detectable IGF-1 from stretched L6 myoblasts.
Impaired Photic Entrainment of Spontaneous Locomotor Activity in Mice Overexpressing Human Mutant α-Synuclein
Authors: Pfeffer Martina , Zimmermann Zuzana , Gispert Suzana , Auburger Georg , Korf Horst-Werner , Von Gall Charlotte
Published: June 2018

Parkinson’s disease (PD) is characterized by distinct motor and non-motor symptoms. Sleep disorders are the most frequent and challenging non-motor symptoms in PD patients, and there is growing evidence that they are a consequence of disruptions within the circadian system. PD is characterized by a progressive degeneration of the dorsal vagal nucleus and midbrain dopaminergic neurons together with an imbalance of many other neurotransmitters. Mutations in α-synuclein (SNCA), a protein modulating SNARE complex-dependent neurotransmission, trigger dominantly inherited PD variants and sporadic cases of PD. The A53T SNCA missense mutation is associated with an autosomal dominant early-onset familial PD. To test whether this missense mutation affects the circadian system, we analyzed the spontaneous locomotor behavior of non-transgenic wildtype mice and transgenic mice overexpressing mutant human A53T α-synuclein (A53T). The mice were subjected to entrained- and free-running conditions as well as to experimental jet lag. Furthermore, the vesicular glutamate transporter 2 (VGLUT2) in the suprachiasmatic nucleus (SCN) was analyzed by immunohistochemistry. Free-running circadian rhythm and, thus, circadian rhythm generation, were not affected in A53T mice. A53T mice entrained to the light–dark cycle, however, with an advanced phase angle of 2.65 ± 0.5 h before lights off. Moreover, re-entrainment after experimental jet lag was impaired in A53T mice. Finally, VGLUT2 immunoreaction was reduced in the SCN of A53T mice. These data suggest an impaired light entrainment of the circadian system in A53T mice.
Biological Basis of Tumor Angiogenesis and Therapeutic Intervention: Past, Present, and Future
Authors: Ranieri Girolamo
Published: June 2018

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The Pattern of Signatures in Gastric Cancer Prognosis
Authors: Machlowska Julita , Maciejewski Ryszard , Sitarz Robert
Published: June 2018

Gastric cancer is one of the most common malignancies worldwide and it is a fourth leading cause of cancer-related death. Carcinogenesis is a multistage disease process specified by the gradual procurement of mutations and epigenetic alterations in the expression of different genes, which finally lead to the occurrence of a malignancy. These genes have diversified roles regarding cancer development. Intracellular pathways are assigned to the expression of different genes, signal transduction, cell-cycle supervision, genomic stability, DNA repair, and cell-fate destination, like apoptosis, senescence. Extracellular pathways embrace tumour invasion, metastasis, angiogenesis. Altered expression patterns, leading the different clinical responses. This review highlights the list of molecular biomarkers that can be used for prognostic purposes and provide information on the likely outcome of the cancer disease in an untreated individual.
Cx43 Channel Gating and Permeation: Multiple Phosphorylation-Dependent Roles of the Carboxyl Terminus
Authors: Ek-Vitorín José F. , Pontifex Tasha K. , Burt Janis M.
Published: June 2018

Connexin 43 (Cx43), a gap junction protein seemingly fit to support cardiac impulse propagation and synchronic contraction, is phosphorylated in normoxia by casein kinase 1 (CK1). However, during cardiac ischemia or pressure overload hypertrophy, this phosphorylation fades, Cx43 abundance decreases at intercalated disks and increases at myocytes’ lateral borders, and the risk of arrhythmia rises. Studies in wild-type and transgenic mice indicate that enhanced CK1-phosphorylation of Cx43 protects from arrhythmia, while dephosphorylation precedes arrhythmia vulnerability. The mechanistic bases of these Cx43 (de)phosphoform-linked cardiac phenotypes are unknown. We used patch-clamp and dye injection techniques to study the channel function (gating, permeability) of Cx43 mutants wherein CK1-targeted serines were replaced by aspartate (Cx43-CK1-D) or alanine (Cx43-CK1-A) to emulate phosphorylation and dephosphorylation, respectively. Cx43-CK1-D, but not Cx43-CK1-A, displayed high Voltage-sensitivity and variable permselectivity. Both mutants showed multiple channel open states with overall increased conductivity, resistance to acidification-induced junctional uncoupling, and hemichannel openings in normal external calcium. Modest differences in the mutant channels’ function and regulation imply the involvement of dissimilar structural conformations of the interacting domains of Cx43 in electrical and chemical gating that may contribute to the divergent phenotypes of CK1-(de)phospho-mimicking Cx43 transgenic mice and that may bear significance in arrhythmogenesis.
TRAIL/NF-κB/CX3CL1 Mediated Onco-Immuno Crosstalk Leading to TRAIL Resistance of Pancreatic Cancer Cell Lines
Authors: Geismann Claudia , Erhart Wiebke , Grohmann Frauke , Schreiber Stefan , Schneider Günter , Schäfer Heiner , Arlt Alexander
Published: June 2018

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignant neoplasms and registers rising death rates in western countries. Due to its late detection in advanced stages, its extremely aggressive nature and the minimal effectiveness of currently available therapies, PDAC is a challenging problem in the clinical field. One characteristic of PDAC is a distinct desmoplasia consisting of fibroblasts, endothelial and immune cells as well as non-cellular components, contributing to therapy resistance. It is well established that the NF-κB signaling pathway controls inflammation, cancer progression and apoptosis resistance in PDAC. This study attempts to identify NF-κB target genes mediating therapy resistance of humane PDAC cell lines towards death ligand induced apoptosis. By using a genome wide unbiased approach the chemokine CX3CL1 was established as a central NF-κB target gene mediating therapy resistance. While no direct impact of CX3CL1 expression on cancer cell apoptosis was identified in co-culture assays it became apparent that CX3CL1 is acting in a paracrine fashion, leading to an increased recruitment of inflammatory cells. These inflammatory cells in turn mediate apoptosis resistance of PDAC cells. Therefore, our data dissect a bifunctional cross-signaling pathway in PDAC between tumor and immune cells giving rise to therapy resistance.