bluuebunny/crossref_metadata_2025 huggingface dataset:
STUDI KONSEP INTEGRASI PENGELOLAAN TERAS CIKAPUNDUNG BERBASIS MASYARAKAT DENGAN KAWASAN HUTAN KOTA BABAKAN SILIWANGI, KOTA BANDUNG
Authors: Farhansyah Mohamad , Bella Priyendiswara Agustina
Published: April 2023

Hutan Kota Babakan Siliwangi and Teras Cikapundung BBWS, which are close to each other, are the lungs and flood controllers in Kota Bandung, which are expected to be well integrated so that they can become one of the uniqueness in Kota Bandung. This study aimed to find out how to manage Teras Cikapundung BBWS, the opinions of the parties involved in the integration, and the role of society and the community in managing Teras Cikapundung BBWS. This study used a field survey technique/observation of the physical condition of the Teras Cikapundung BBWS area as well as the activities and roles of the surrounding community. Interviews were taken involving the management, related agencies, local communities, and visitors. This research results in obtaining the right, effective proposals for improving the surrounding community in managing Teras Cikapundung BBWS integrated with the Babakan Siliwangi area.
Keywords: Community; hutan kota babakan siliwangi; integration; management; teras Cikapundung BBWS
Abstrak
Hutan Kota Babakan Siliwangi dan Teras Cikapundung BBWS yang saling berdekatan merupakan paru-paru dan pengendali banjir di Kota Bandung, yang diharapkan dapat terintegrasi dengan baik dengan saling terhubung agar bisa menjadi salah satu keunikan di Kota Bandung. Tujuan penelitian ini adalah untuk mengetahui cara pengelolaan Teras Cikapundung BBWS, mencari tahu pendapat pihak-pihak yang terkait apabila Teras Cikapundung diintegrasikan dengan Babakan Siliwangi, dan mengetahui peran masyarakat dan komunitas dalam mengelola Teras Cikapundung BBWS. Penelitian ini menggunakan Teknik survey lapangan/observasi kondisi fisik Kawasan Teras Cikapundung BBWS serta kegiatan dan peran masyarakat sekitar. Wawancara diambil dengan melibatkan pihak pengelola, instansi terkait, masyarakat sekitar, dan pengunjung. Hasil dari penelitian ini adalah didapatkannya usulan yang tepat dan efektif dalam meningkatkan masyarakat sekitar dalam mengelola Teras Cikapundung BBWS yang diintegrasi dengan Kawasan Babakan Siliwangi.
Assessment of Responsibilities of Universities through Quality Assurance Information Published
Authors: Vu Anh Bui , Hang Nguyen Thi
Published: April 2023

Improving accountability in university autonomy is a trend of countries with advanced university governance in the world. The higher the degree of autonomy, the higher the transparency and accountability of activities in educational institutions is required. This brings sustainability to the autonomy mechanism, giving stakeholders confidence in the educational institution itself. On December 28, 2017, the Ministry of Education and Training issued Circular 36/2017/TT-BGDDT promulgating the Regulation on public implementation for education and training institutions under the national education system. This Circular requires educational institutions to publicize information about their commitment to education quality and actual education quality, resources for education quality assurance, financial revenues and expenditures (collectively referred to as quality assurance information) on their websites in June every year. To assess the quality of accountability of higher education institutions through this disclosure mechanism, the authors have studied the status of information disclosure of 107 Vietnamese higher education institutions. The evaluation is focused on the timeliness, completeness, transparency in publicizing the quality of education information. The research results show that there is a clear difference in public implementation, which is reflected in 3 main results: First: There is irregularity and incompleteness of the implementation of accountability, the number of non-implementation rate is quite high. Second: The disclosure of information is fully implemented by some groups of universities only. The results of One-Way ANOVA test on the mean difference between groups of universities showed that there was a difference with statistical significance p < 0.05. This proves that there is a difference between the groups of universities studied in the implementation of accountability through the mechanism of quality assurance information disclosure.
CONSTRUÇÃO E VALIDAÇÃO DE FERRAMENTA PREVENTIVA SOBRE INCOMPATIBILIDADE MEDICAMENTOSA EM VIA Y
Authors: Araújo Márcia Jordana , Linhares Maria Isabel , Fonteles Adna Vasconcelos , De Araújo Alana Bruna , De Araújo Neto Joaquim Horácio , Linhares Antonia Maria Railene de Lima Cunha , Dias Luiza Jocymara Lima Freire , Ribeiro Larisse Campos
Published: April 2023

Introdução: A terapia com medicamentos endovenosos é muito utilizada nas unidades hospitalares, porém, possui uma elevada chance de incidentes, principalmente quando os medicamentos são administrados simultaneamente em via Y. Essa prática pode resultar em incompatibilidades medicamentosas classificadas em reações físicas e químicas. Objetivo: Construir e validar uma ferramenta preventiva de incompatibilidade medicamentosa em via Y. Método: Estudo metodológico com abordagem quantitativa. Foi desenvolvido em três etapas: Levantamento bibliográfico, construção e diagramação do material e por fim, a validação da ferramenta preventiva. Para validação, a ferramenta preventiva foi submetida ao processo de validação de face e conteúdo por juízes com expertise na temática. Resultados: Construiu-se e validou-se uma ferramenta preventiva através da busca de dados na literatura com a participação de sete juízes especialistas na temática. Os itens avaliativos referentes a tabela de incompatibilidade medicamentosa quanto aos objetivos, estrutura, apresentação e relevância da ferramenta preventiva foi considerada válida, pois foram julgados como adequado pelos especialistas. Conclusão: A validação de conteúdo, foi considerada válida pelos juízes, portanto, espera-se que o material alcance o seu objetivo ao ser aplicado durante a prática clínica. Dessa forma, será disponibilizado à instituição para que seja utilizado, favorecendo a prevenção de danos e contribuindo para a segurança dos pacientes, bem como melhorando a qualidade da assistência e educação em saúde.
PERANCANGAN DAN IMPLEMENTASI APLIKASI BESERTA WEBSITE MENGGUNAKAN DATABASE MYSQL UNTUK PELAYANAN KESEHATAN PADA MASA PANDEMI COVID-19 DI PUSKESMAS LINGGARJATI
Authors: Sussi Sussi , Hertiana Sofia Naning , Syach Ajay Muhammad Atalarik , Pratama Nicholas Teja
Published: April 2023

Pengabdian kepada masyarakat ini bertujuan untuk implementasi aplikasi beserta website untuk membantu sistem pelayanan kesehatan pada puskesmas. Implementasi ini diikuti oleh tenaga kesehatan dari puskesmas Linggarjati Kuningan Jawa Barat. Dalam implementasi ini tim pelaksana pengabdian terdiri dari beberapa dosen tetap Fakultas Teknik Elektro (FTE) prodi S1 Teknik Telekomunikasi. Adapun metode implementasi yang digunakan adalah dengan cara memberikan aplikasi beserta website secara langsung dengan menggunakan instrumen yang diberikan setelah pelatihan. Target yang akan dicapai setelah pelatihan ini adalah agar bisa membantu sistem pelayanan pada puskesmas Linggarjati jadi lebih optimal dan efisien pada saat pandemi Covid-19. Adapaun hasil yang diharapkan dari pelatihan ini adalah menurunnya kasus Covid-19 di Indonesia khususnya pada daerah Kuningan Jawa Barat.Kata Kunci: Website, Aplikasi, Covid-19, Sistem pelayanan kesehatan.
PELATIHAN PEMBUATAN WATER IONIZER UNTUK SISWA DAN GURU JURUSAN TEKNIK TENAGA LISTRIK SMK MERDEKA KOTA BANDUNG
Authors: Kurniawan Ekki , Pangaribuan Porman , Rodiana Irham Mulkan , Rachamat Noer , Raihan Fawwaz M , Aprianto Aldi , Sadewo Adyatma Hugo , Yudhistira Arie , Suryadin Ahmad , Prina Dian
Published: April 2023

Tahun 2045 Indonesia diproyeksikan akan menjadi negara maju, dengan ekonomi terbesar ke-4 di dunia. Prediksi tersebut dilatarbelakangi dengan bonus demografi yang akan terjadi pada tahun 2030-2040. Hal ini merupakan keuntungan jika berhasil mendidik generasi mudanya. Sebaliknya akan menjadi “bencana” apabila kualitas masyarakat Indonesia tidak disiapkan dengan baik. Salah satu upaya untuk mencapai keuntungan ini adalah dengan memperhatikan tingkat kesehatan. Pada tahun 2021 indeks rata-rata kesehatan global sebesar 40,2 poin. Indonesia berada di posisi keempat Asia Tenggara (peringkat 30 dunia) di bawah Thailand, Singapura dan Malaysia. Masalah lainnya adalah masih banyaknya alumni SMK yang menganggur, sehingga tingkat kesehjateraannya masih kurang. Program pengabdian masyarakat ini adalah program pengabdian masyarakat lanjutan yang dilakukan pada siswa dan guru di SMK Merdeka Bandung. Pengabdian masyarakat ini berupa pelatihan membuat alat Portable Water Ionizer (PWI). PWI menghasilkan air alkali yang mengandung gas hidrogen, bermanfaat untuk menghasilkan antioksidan. Air asam yang dihasilkan dapat dimanfaatkan sebagai antiseptik dan desinfektan. Air alkali memiliki kandungan ion kalsium, magnesium, natrium,dan kalium lebih banyak dari air biasa sehingga dapat menguatkan tulang,  sendi, otot, dan melancarkan peredaran darah.  Siswa SMK diharapkan dapat memproduksi PWI secara masal, untuk dapat dikomersialkan. Dengan demikian diharapkan tingkat pengangguran alumni SMK Listrik bisa menurun, dan sekaligus juga kesejateraan dan kesehatan masyarakat akan meningkat. Hasil dari program ini berupa 30 unit PWI, yang telah teruji dapat menghasilkan air hidrogen, air alkali, dan air asam yang bermanfaat untuk kesehatan.Kata Kunci: Indonesia, Kesehatan, SMK,Portable Water Ionizer, Masyarakat
PENINGKATAN MOTIVASI BELAJAR MELALUI PELATIHAN MOTIVASI PADA SISWA SMK YPPS SUMEDANG
Authors: Dudija Nidya , Indiyati Dian , Pratomo Triaji Prio
Published: April 2023

Motivasi belajar merupakan salah satu aspek penting yang perlu menjadi perhatian pada perkembangan remaja selaku siswa menengah atas. Motivasi memegang peranan penting untuk meningkatkan prestasi akademik siswa, terlebih pada siswa SMK yang memiliki orientasi bekerja setelah lulus sekolah.  Kegiatan pengabdian masyarakat berupa pelatihan/penyuluhan dilakukan berkolaborasi antara Fakultas Ekononi Bisnis dan Fakultas Komunikasi Bisnis dengan masyarakat sasar 83 siswa SMK YPPS jurusan tata boga, busana dan perhotelan. Kegiatan pengabdian masyarakat ini memberikan wawasan dan penyuluhan terkait pengembangan diri dan peningkatan motivasi belajar. Pada kegiatan ini peserta mengisi kuesioner motivasi belajar yang terdiri dari 12 aitem pernyataan terkait motivasi intrinsik dan ekstrinsik. Diperoleh hasil melalui analisis deskriptif motivasi siswa SMK YPPS Pariwisata Sumedang berada pada kategori Tinggi sebesar 82,3%. Hasil pengabdian masyarakat dan penelitian ini tentunya dapat menjadi acuan dan pengetahuan kepada para guru di SMK YPPS dalam memberikan materi ajar dan mengembangkan kegiatan belajar yang menarik sehingga mampu meningkatkan motivasi belajar siswa dan membantu siswa untuk mengenali dirinya dan melakukan pengembangan diri, sehingga siswa – siswa YPPS dapat tumbuh menjadi pribadi yang unggul dan percaya diri untuk mencapai cita – citanya.   Kata Kunci: Motivasi Intrinsik, Motivasi Ekstrinsik
PEMBELAJARAN LITERASI DIGITAL PARA PEJUANG DAKWAH LPD AL BAHJAH CIREBON
Authors: Anggraini Clara Novita , Pertiwi Mirah , Rustandi Dudi , Aprilianza Devi Tri , Ramadhani Ocha Tisepta , Aksamala Dewa Ayu
Published: April 2023

Setiap tahunnya, trend pengguna internet di Indonesia terus mengalami peningkatan. Akan tetapi, kenaikan signifikan tidak dibarengi dengan penguasaan terhadap dampak yang ditimbulkannya. Misalnya belum mampunya membedakan antara informasi yang kredibel dan berita bohong (hoaks). Tingkat kemunculan hoaks yang cukup tinggi kebanyakan merupakan informasi yang memiliki irisan dengan agama. Oleh karena itu, para Pejuang Dakwah memiliki peran signifikan dalam mendorong pemberantasan hoaks melalui dakwah.  Pada dasarnya hoaks sangat bertentangan dengan agama. Oleh karena itu, Telkom University bekerja sama dengan Lembaga Pendidikan Dakwah (LPD) Al-Bahjah menyelenggarakan pembelajaran literasi digital dakwah untuk para pejuang dakwah. Pejuang dakwah LPD Al Bahjah adalah para santri yang mengelola media siar sebagai sarana dakwah secara digital. Media yang dikelola antara lain youtube, Instagram, dan radio. Berdasarkan hasil observasi selama kegiatan PKM ini berlangsung, kegiatan pembelajaran literasi digital dakwah bagi pejuang dakwah LPD Al-Bahjah telah bermanfaat dalam menambah pengetahuan, serta meningkatkan skill literasi digital dakwah para pejuang dakwah LPD Al-Bahjah. Kata Kunci: Literasi Digital, Pejuang Dakwah, LPD Al-Bahjah
Uma análise das principais causas de cegueira em bebês: catarata congênita e retinopatia da prematuridade
Authors: Ourofino Eder da Silva , Sgarbi Mariana Teixeira , Sgarbi Maria Clara Teixeira , Siqueira Emílio Conceição de
Published: April 2023

Objetivo: Analisar as características da Catarata Congênita (CC) e da Retinopatia da Prematuridade (ROP). Revisão bibliográfica: A deficiência visual na criança impacta o desenvolvimento, gerando desvantagens nos processos educativos, independência, aprendizagem e adaptação. Em todo o mundo as principais causas de baixa visual na primeira infância são a ROP e CC. Em países de baixa e média renda, predomina a catarata CC e, em países de baixa renda, ROP. A ROP é ​​uma vitreorretinopatia proliferativa que afeta bebês prematuros e é uma das principais causas de cegueira infantil em todo o mundo, já a CC é definida como qualquer opacidade do cristalino presente no nascimento ou na primeira infância. Considerações finais: A catarata congênita e a retinopatia da prematuridade constituem as principais causas de baixa visual e cegueira na primeira infância. Nesse contexto, é essencial a implementação dos testes de triagem no caso da CC o teste do reflexo vermelho e no caso da ROP com exames de fundo de olho nos recém-nascidos prematuros abaixo de 1.500 g ou com IG <30 semanas. Dessa forma, oportunizando um diagnóstico precoce é possível reduzir as sequelas de ambas as patologias.
Klippel-Trenaunay syndrome: A case report of orthodontic-surgical treatment
Authors: Tehranchi Azita , Tabrizi Reza , Rafsanjan Katayoun Talebi
Published: April 2023

Introduction:

Klippel-Trenaunay syndrome (KTS) is a congenital disorder characterized by a clinical triad of capillary malformation; varicose veins; and soft tissue and/or bony hypertrophy. This rare syndrome has an estimated incidence of about 2–5/100,000 live births. KTS usually affects the extremities but occasionally can manifest in the craniofacial region, including the oral cavity.

Case Presentation:

Our patient, a 17-year-old girl, presented with large areas of port wine stain, unilateral hypertrophy of the facial region, and varicose veins. She was diagnosed with KTS. Orthodontic treatment followed by orthognathic surgery was performed to address her complaint of facial asymmetry and poor chewing efficacy. Treatment resulted in significant improvement in her appearance and dental occlusion and our patient was very satisfied with the results.

Conclusion:

This report illustrates an orthodontic and surgical treatment approach of a case with KTS. Effective management of orthodontic and facial manifestations of KTS considerably enhances the patient’s function, appearance, and overall quality of life.
Mole-BERT: Rethinking Pre-training Graph Neural Networks for Molecules
Authors: Xia Jun , Zhao Chengshuai , Hu Bozhen , Gao Zhangyang , Tan Cheng , Liu Yue , Li Siyuan , Li Stan Z.
Published: April 2023

Recent years have witnessed the prosperity of pre-training graph neural networks (GNNs) for molecules. Typically, atom types as node attributes are randomly masked and GNNs are then trained to predict masked types as in AttrMask \citep{hu2020strategies}, following the Masked Language Modeling (MLM) task of BERT~\citep{devlin2019bert}. However, unlike MLM where the vocabulary is large, the AttrMask pre-training does not learn informative molecular representations due to small and unbalanced atom `vocabulary'. To amend this problem, we propose a variant of VQ-VAE~\citep{van2017neural} as a context-aware tokenizer to encode atom attributes into chemically meaningful discrete codes. This can enlarge the atom vocabulary size and mitigate the quantitative divergence between dominant (e.g., carbons) and rare atoms (e.g., phosphorus). With the enlarged atom `vocabulary', we propose a novel node-level pre-training task, dubbed Masked Atoms Modeling (MAM), to mask some discrete codes randomly and then pre-train GNNs to predict them. MAM also mitigates another issue of AttrMask, namely the negative transfer. It can be easily combined with various pre-training tasks to improve their performance. Furthermore, we propose triplet masked contrastive learning (TMCL) for graph-level pre-training to model the heterogeneous semantic similarity between molecules for effective molecule retrieval. MAM and TMCL constitute a novel pre-training framework, Mole-BERT, which can match or outperform state-of-the-art methods in a fully data-driven manner. We release the code at \textcolor{magenta}{\url{https://github.com/junxia97/Mole-BERT}}.
Correlation of binding site properties with chemistries used for generation of ultra-large virtual libraries.
Authors: Song Robert , Nicklaus Marc , Tarasova Nadya
Published: April 2023

Although the size of virtual libraries of synthesizable compounds is growing rapidly, we are still enumerating only tiny fractions of the drug-like chemical universe. At the same time, our ability to mine these newly generated libraries also lags their growth. That is why fragment-based approaches that utilize on-demand virtual combinatorial libraries are gaining popularity. These à la carte libraries utilize synthetic blocks that have been shown to be effective binders in parts of target protein pockets. There is, however, no data on the potential impact of the chemistries used for making on-demand libraries on the hit rates during virtual screening. There are also no rules to guide in selection of these synthetic methods for libraries production. We have used the SAVI (Synthetically Accessible Virtual Inventory) library, constructed using 53 reliable reaction types (transforms), to test for correlations between these chemistries and docking hit rates for 39 well- characterized protein pockets. The data shows that the hit rate depends on the chemistry used and that chemistry selection can be optimized based on pocket properties.
Multimodal investigation of electronic transport in PTMA: Impact on organic radical battery performance
Authors: Daniel Davis Thomas , Oevermann Steffen , Mitra Souvik , Rudolf Katharina , Heuer Andreas , Eichel Rüdiger-A. , Winter Martin , Diddens Diddo , Brunklaus Gunther , Granwehr Josef
Published: April 2023

Organic radical batteries (ORBs) represent a viable pathway to a more sustainable energy storage technology compared to conventional Li-ion batteries. For further materials and cell development towards competitive energy and power densities, a deeper understanding of electron transport and conductivity in organic radical polymer cathodes is required. Such electron transport is characterised by electron hopping processes, which depend on the presence of closely spaced hopping sites. Using a combination of electrochemical, electron paramagnetic resonance (EPR) spectroscopic, and theoretical molecular dynamics (MD) as well as density functional theory (DFT) modelling techniques, we explored how compositional characteristics of cross-linked poly(2,2,6,6-tetramethyl-1-piperidinyloxy-4-yl methacrylate) (PTMA) polymers govern electron hopping and rationalise their impact on ORB performance. Electrochemistry and EPR spectroscopy not only show a correlation between capacity and the total number of radicals in an ORB using a PTMA cathode, but also indicates that the state-of-health degrades about twice as fast if the amount of radical is reduced by 15%. The presence of up to 3% free monomer radicals did not improve fast charging capabilities. Pulsed EPR indicated that these radicals readily dissolve into the electrolyte but a direct effect on battery degradation could not be shown. However, a qualitative impact cannot be excluded either. The work further illustrates that nitroxide units have a high affinity to the carbon black conductive additive, indicating the possibility of its participation in electron hopping. At the same time, the polymers attempt to adopt a compact conformation to increase radical–radical contact. Hence, a kinetic competition exists, which might gradually be altered towards a thermodynamically more stable configuration by repeated cycling, yet further investigations are required for its characterisation.
Enhancing the nucleophilicity of benzylic boronates enables the divergent formation of C−C and C−X bonds
Authors: Gao Liuzhou , Liang Xinyi , He Linke , Li Guoao , Chen Shengda , Cao Jia , Ma Jing , Wang Guoqiang , Li Shuhua
Published: April 2023

Tetracoordinated boron species generated from the complexation of organoboron compounds with bases are highly important intermediates in molecular fragments coupling. The type of base significantly impacts both the reaction activity and mechanism of organoboron compounds. Herein, our structural and mechanistic insights show that the full heterolytic cleavage of the C−B bond in benzylic boronates, leading to the formation of benzyl potassium species, can be achieved by increasing the amount of alkoxides. This, in turn, significantly enhances the nucleophilicity of both secondary and tertiary benzylic boronates. This mechanistic insight has proven valuable in the divergent construction of C(sp3)−C(sp3 or sp2) and other C−X bonds (X = Si, Ge, Sn, S, Se), as demonstrated through the integration of base-catalyzed silylboration/diborylation reactions. Through machine-learning-assisted screening of approximately 104 substrate combinations, we have expanded the scope of electrophiles for this transformation to include challenging aromatic heterocycles. Moreover, the synthetic potential of this protocol was demonstrated through the construction of drug-relevant molecules that contain 1,1-diaryl pharmacophores.
Basic principle from electrospray ionization to soft ionization mass spectrometry and development of ion source:part Ⅰ
Authors: luo jiehong
Published: April 2023

Since the electrospray phenomenon was discovered, there is still an unsolved mystery about the prinple of generating charged analyte in the soft ionization phenomenon which represented by ESI. Scientists have described this process from different perspectives, but current theories still can not explain many experimental phenomena. At the same time, the slow development of the theory restricts the design and development of ion source, making it encounter many bottlenecks from the laboratory to commercialization. In this paper, the principle of electrospray ionization and soft ionization mass spectrometry is briefly introduced, and the application of ion migrate and transport mechanism is discussed, all are expected to be used in the development of ion sources.
Opportunities for Healthcare Research in India
Authors: Raju Koneri Dr. , Ph.D. M.Pharm.
Published: April 2023

None
Analytical Method Development and Validation of Amoxicillin and Dicloxacillin in API and its Dosage Form by RP-HPLC
Authors: K N Pramodini , Richards M Paul , A Vishwanath B
Published: April 2023

Background Amoxicillin and dicloxacillin are the antibiotics useful for the treatment of a number of bacterial infections constituting the first line of treatment for middle ear infections. It may also be used for Strep throat pneumonia skin infections and urinary tract infections. They are taken by mouth or less commonly in injection form.Objective The main objective of the simultaneous estimation of Amoxicillin and Dicloxacillin was to establish identity purity physical characteristics and potency of the drugs.Methodology The estimation of Amoxicillin and Dicloxacillin was done by Reversed-phase- High performance liquid chromatography RP-HPLC. The phosphate buffer had a pH of 4.6 and the mobile phase was optimized consisting of Methanol Phosphate buffer mixed in the ratio of 7030 vv. A Symmetry C18 4.6 x 150 mm 5 mm Make XTerra column was used as stationary phase.Results The results were in good agreement with those obtained with official HPLC with maximum absorption using mobile phase which was optimized consisting of MethonolPhosphate buffer mixed in the ratio of 7030 vv. A Symmetry C18 4.6 x 150 mm 5 mm Make XTerra column was used as stationary phase. According to ICH guidelines all the data were achieved with good precision accuracy and robustness.Conclusion On the basis of results of assay and validation parameters it can be concluded that the proposed method was simple fast accurate and precise. It is possible to estimate Amoxicillin and Dicloxacillin dosage forms simultaneously in a combination capsule dosage form that can be used on a regular basis.
In silico Studies, Synthesis and Antibacterial Activity of Heterocyclic Compounds with Mannich Bases
Authors: Geetha Priya Loganathan C , Syiemlieh Aidajinghun , Mawblei Jaspershield , Pandit Deep
Published: April 2023

Aim The present study aimed to identify the potent 123-triazole derivatives for synthesis and also assess their anti-bacterial activity.Methodology In silico design of novel analogues was carried out for ten derivatives using Auto Dock Vina and compared with standard drug Ciprofloxacin. Swiss ADME software was used to analyze lsquoLipinski Rule of Fiversquo and drug likeness properties. Three derivatives which obeyed rule of five having desired physicochemical properties and highest docking score were synthesized PDB code 2K35. The synthesis was carried out in two step process to determine their antibacterial activity. The synthesized compounds were structurally elucidated using Fourier-transform infrared spectroscopy FTIR Nuclear Magnetic Resonance 1H NMR and Mass spectroscopy .Results Antibacterial activity of different compounds was observed by disc diffusion method against two organisms E. coli and Streptococcus. Among the tested compounds 4A showed significant antibacterial activity. Compounds 6A and 8A also exhibited appreciable antibacterial activity against E. coli while compound 6A showed appreciable antibacterial activity against Streptococcus.Conclusion According to data obtained from the present study piperazine incorporated triazole derivatives were found to possess effective antibacterial activity. Further modifications of triazole based compounds at different positions to generate new molecules with potent anti-tumor activities will be described in future.
Evaluation of The COVID-19 Vaccination Program for the Elderly in the Rawalo Health Center With the CIPP (Context, Input, Process, And Product) Model
Authors: Gunanto Gunanto , Septo Pawelas Arso  , Rani Tiyas Budiyanti
Published: April 2023

Rawalo sub-district had a relatively high number of COVID-19 cases compared to other sub-districts in Banyumas Regency. The government provides COVID-19 vaccination which aims to reduce the number of COVID-19 cases by forming Herd Immunity in the community. The elderly are a group at high risk of morbidity and mortality due to exposure to COVID-19. However, the coverage of COVID-19 vaccination for the elderly at the Rawalo Health Center is still relatively low. This study was aimed  to evaluate the program with the CIPP (Context, Input, Process, Product) model in a complex and comprehensive manner regarding how the implementation of the COVID-19 vaccination program in the elderly. This research was a qualitative study with a descriptive approach using observation and in-depth interview methods selected by purposive sampling technique. The research subjects as the main informants included the Head of the Puskesmas, the Head of the COVID-19 Vaccination Program Team, the COVID-19 Vaccination Coordinator and health cadres. Meanwhile, the elderly group and the Banyumas Regency Health Office as triangulation informants. The results showed that vaccination coverage in the elderly was still low, at 10% for dose 3. This was due to less thorough education, lack of human resources (vaccination officers), and ineffective coordination, there is data that is not synchronous or valid. There are technical and non-technical obstacles in recording and reporting. Thus, improvements need to be made to aspects that affect the vaccination implementation process and low coverage.
Influenza A(H3N2) infection followed by separate COVID-19 infection
Authors: Gregianini Tatiana Schäffer , Salvato Richard Steiner , Baethgen Ludmila Fiorenzano , Piazza Cláudia Fasolo , Barcellos Regina Bones , Godinho Fernanda Marques , Veiga Ana Beatriz Gorini da
Published: April 2023

This study describes the case of a health professional infected first by influenza virus A(H3N2) and then by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 11 days later. Respiratory samples and clinical data were collected from the patient and from close contacts. RNA was extracted from samples and reverse transcription–quantitative polymerase chain reaction (RT-qPCR) was used to investigate the viruses. The patient presented with two different illness events: the first was characterized by fever, chest and body pain, prostration and tiredness, which ceased on the ninth day; RT-qPCR was positive only for influenza virus A(H3N2). Eleven days after onset of the first symptoms, the patient presented with sore throat, nasal congestion, coryza, nasal itching, sneezing and coughing, and a second RT-qPCR test was positive only for SARS-CoV-2; in the second event, symptoms lasted for 11 days. SARS-CoV-2 sequencing identified the Omicron BA.1 lineage. Of the patient’s contacts, one was coinfected with influenza A(H3N2) and SARS-CoV-2 lineage BA.1.15 and the other two were infected only with SARS-CoV-2, one also with Omicron BA.1.15 and the other with BA.1.1. Our findings reinforce the importance of testing for different viruses in cases of suspected respiratory viral infection during routine epidemiological surveillance because common clinical manifestations of COVID-19 mimic those of other viruses, such as influenza.
Regulação de resíduos de agrotóxicos em alimentos no MERCOSUL: discussão necessária para vigilância sanitária
Authors: Centurión Maria Pasionaria Blanco , Peres Frederico , Moreira Josino Costa , Jacob Silvana do Couto
Published: April 2023

O objetivo deste estudo descritivo e exploratório, de base qualitativa, foi identificar as resoluções do MERCOSUL sobre resíduos de agrotóxicos em alimentos publicadas entre 1991 e 2022, analisando os processos de harmonização regional desses marcos e sua incorporação ao arcabouço regulatório dos Estados Partes fundadores do bloco (Argentina, Brasil, Paraguai e Uruguai). A análise identificou pontos importantes para a regulação e o monitoramento de resíduos de agrotóxicos em alimentos no MERCOSUL, como as sinonímias utilizadas na definição de agrotóxicos e a abrangência do sistema regulatório de cada país, as marcadas diferenças no alcance dos principais marcos regulatórios nacionais, a incorporação desigual de regulamentos internacionais e regionais pelos Estados Partes e os desafios para a harmonização da legislação sobre resíduos de agrotóxicos em alimentos no âmbito do MERCOSUL. Para além dos limitados avanços observados na tentativa de harmonizar a legislação pertinente dentro do bloco, observa-se a necessidade de avançar, nacional e regionalmente, nos processos regulatórios sobre resíduos de agrotóxicos em alimentos, garantindo a qualidade dos produtos e serviços ofertados à população e fortalecendo, assim, um comércio de alimentos mais seguros e produzidos a partir de processos menos prejudiciais ao ambiente no MERCOSUL.
The Writing Desk
Authors:   , Morris Diane
Published: April 2023

This project explores the use of the graphic novel format to convey an historical narrative, with the goal of giving contemporary readers (particularly young women) an enhanced experience of what it was like to live as a woman in late Victorian and early Edwardian New Zealand. The thesis examines the use of visual narrative techniques in a range of historical graphic novels and considers how these can be enhanced and expanded. An historical graphic novel is then created, based on actual events, centred on the opportunities and struggles of two young women growing up in South Canterbury in the late 19th and early 20th centuries and their aspirations for the future. The graphic novel is then shared with a sample of contemporary readers including young women, relatives of the characters depicted, and secondary school educators. Their reactions are collected in a de-identified survey, to determine the effectiveness of the graphic novel's use of particular visual narrative techniques in achieving the project's goal. The conclusion highlights ways in which the graphic novel can be particularly effective at providing readers with a compelling, vivid experience and an understanding of the past.
Charting Null Island
Authors:   , Zhou Xianhao
Published: April 2023

This speculative design-led research investigation is 'sited' on Null Island, a 'mythological' island located in the Atlantic Ocean at 0° latitude and 0° longitude, at the intersection of the prime meridian and the equator. While no physical island is actually located on this site, it is marked by a permanently moored weather buoy called "soul". Looking at the geographical location of Null Island from an East-West perspective, the equator is a 'real' line inscribed on the centre of the globe. From the North-South perspective, the meridian through Greenwich England that we consider to be zero degrees of longitude is an ‘unreal’ line. It was designated the Prime Meridian by the British Empire during its greatest period of colonial upheaval, whilst other nations historically had their own guidelines for where the ‘prime’ meridian was located. Viewed in this sense, the Prime Meridian is culturally charged and 'imaginary'. Today, the 'island' marking the intersection of the equator and the Prime Meridian serves as an absolute cartographic reference for navigation databases in computing and placenames. In this sense, Null Island represents a liminal territory between fiction and reality, a place where a natural order, a constructed order, and a digital order coalesce.

In architectural cartography, the spatial potential of the architectural mapping of the unreal, related to the imagination, has been largely absent. The principal aim of this thesis is to explore the dual realms of Null Island - a 'mythical' island at the 'real' intersection of 0° longitude and 0° latitude — by using three-dimensional, speculative cartographic representation as a critical method.

The thesis investigation asks: How can three-dimensional, imaginative cartographies establish place identity for a placeless place located between fiction and reality?
Etlingera (Zingiberaceae) in Bogor Botanic Gardens: Potential Benefits and Its Conservation Status
Authors: Novitasari Yeyen
Published: April 2023

Indonesia is one of mega biodiverse countries in the world, with a high global biodiversity index and many vascular plant species. However, not all plant species are known in terms of their uses, potential benefits, and conservation status. One of example is genus Etlingera, where further studies are required. Therefore, this study aimed to provide information on the potential benefits and uses of the genus Etlingera and to investigate its conservation status. The study was conducted using the method of literature study, an inventory of potential uses, and an inventory of the genus Etlingera living in Bogor Botanic Gardens through direct observation. Six species of the genus Etlingera were collected from the Bogor Botanic Gardens, namely Etlingera brevilabrum, E. elatior, E. hemisphaerica, E. loerzingii, E. megalocheilos, and E. walang, conservation status of three species (E. brevilabrum, E. hemisphaerica, and E. megalocheilos) is Least Concern (LC), two species (E. elatior and E. walang) are Data Deficient (DD), and one species (E. loerzingii) is Vulnerable (VU). All species are commonly used as spices, condiments, cosmetics, and traditional medicine to cure various diseases, possibly also as ornamental plants. The secondary metabolites present in some species, namely E. brevilabrum, E. elatior, and E. hemisphaerica can be used as antimicrobial, antifungal, and antioxidant agents.
Diversity of Moss Species (Bryophyta) In Senggani Ravine Tourism Area, Tulungagung Regency
Authors: Kartikasari Desi , Anon Widodo Gading , Habibah Nur , Zahratul Asna Rakhmi
Published: April 2023

Moss plants (Bryophyta) are found in every habitat, and their presence in an ecosystem is controlled by environmental circumstances. The Senggani Ravine tourism area is a popular tourist attraction comprising a pine forest with extensive moss communities. This work aimed to assess the diversity of mosses (Bryophyta) in the Senggani Ravine tourism area for the first time. In June 2022, exploratory descriptive research of moss diversity was undertaken by a free walk around the Senggani Ravine tourism area from a predetermined position point (purposive sampling) using observation, documentation, literature study, and measurement of abiotic elements for data collection. Based on the results, twenty species of mosses were identified and can be divided into four classes, namely the Bryopsida, Polytrichopsida, Jungermanniopsida, and Marchantiopsida. The species identified were Barbulla indica, Fissidens purpusillus, Fissidens biformis, Fissidens biformis, Octoblepharum albidum, Rhizonium punctatum, Mnium hornum, Philonotis marchica, Fontinalis antipyretica, Hypnum cupressiform, Polytrichastrum formosum, Lejeunea flava, Lejeunea cavifolia, Bazzania prareupta, Bazzania vittata, Riccia junghuhniana, Marchantia emarginata, Marchantia polymorpha, Dumortiera hirsuta, and Lunularia cruciate. Abiotic factor measurements revealed that zone 3, which has a soil pH of 6, an air temperature of 24.1 C°, an 84% humidity level, and 200 Cd of light cm-1, is the most favorable area for moss growth. We can infer that the Senggani Ravine tourism area is still primarily undisturbed because the moss flora is still quite diverse and varied.
Effects of Zinc Accumulation on Earthworm Aporrectodea caliginosa (Haplotaxida: Lumbricidae)
Authors: Mahmood Safaa Mohammed , Mohammed Adnan Musa
Published: April 2023

Earthworms are key to the earth's ecosystem, which helps the soil increase its fertility and repair its existing elements, as well as remove contaminants. This study investigated the accumulation of Zn in the earthworm Aporrectodea caliginosa after 15 days of exposure. The worms were grown in media with different concentrations of Zn between 750 and 1500 ppm. Each treatment consisted of three replicates, containing 30 worms. A control group without Zn was also used. Data were analyzed by using Duncan Multi–Range. The results revealed that A. caliginosa had a strong ability to accumulate Zn in its tissue compared to the control group. It was noticed that the increase of the heavy metal in the worm´s tissue is associated with the elevation of the metal in its media. The results show a significant loss of weight in the worm´s body and loss in the growth rate; they also shown a decrease in specific growth rate. Moreover, there was a significant decrease in the worm length, showing a high effect, especially after 15 days of breeding with all concentrations used in this study. The researchers recommend using earthworms to purify the soil from contaminants because earthworm has a great ability to get rid of all pollutants, whether metals or pesticides or parasites, especially in industrialized countries and agricultural lands.
TRACKS AND TRAILS OF ED-TECH FIRMS IN INDIA
Authors: Gnanakumar Baba , Baby M K
Published: April 2023

The Indian educational technology (Edtech) industry has been experiencing remarkable growth in recent years, driven by a range of factors, including increased demand, investor interest, and mergers and acquisitions. The COVID-19 pandemic has also played a significant role in accelerating the growth of the industry. With the closure of schools and universities during lockdowns, there was a surge in demand for online education solutions. In India, the growth rate of edtech firms decreased during the year 2022. An analysis of customer reviews from 2020 to 2022 are used in this article to determine why edtech firms succeed and fail.
Pelatihan Aplikasi Android MH (Morbus Hansen) Mobile Pada Penderita Kusta dan Keluarga
Authors: Aditya Ronal Surya , Kodriyah Lailatul , Afiani Nurma , Sunaryo Eri Yanuar Akhmad Budi , Sulistyorini Anita , Soelistyowati Endang
Published: April 2023

Introduction:Kusta adalah penyakit infeksi kronis yang disebabkan oleh Mycobacterium leprae, ditandai dengan sangat panjangnya masa inkubasi, kesulitan dalam mendeteksi tanda dan gejala. Indonesia menduduki urutan ketiga setelah India dan Brazil dengan jumlah penderita kusta sebanyak 20.023 kasusObjectives: membentuk kampung ramah kusta, dimana mereka tidak akan melakukan stigma pada penderita kusta, dengan cara memandirikan perawatan penderita kusta dengan memaksimalkan support sistem yang ada di sekitar penderitaMethods: Metode yang dilakukan dalam pengabdian masyarakat ini adalah pelatihan yang melalui 3 tahap, yaitu persiapan, pelaksanaan dan evaluasiResults:  penderita, keluarga dan kader beserta perawat penanngung jawab dan perawat desa mendapatkan pengetahuan terkait dengan aplikasi kusta, serta berkomitmen untuk meningkatkan derajat kesehatan penderita kustaConclusions:  Program pengabdian pada masyarakat ini bertujuan untuk memberikan pelatihan penggunaan aplikasi kepada penderita kusta dan keluarga. Target yang hendak dicapai dalam program ini adalah peserta mampu mengetahui dan menggunakan aplikasi untuk peningkatan derajat kesehatan mereka. Hasil yang dicapai berupa kemampuan penderita kusta dan keluarga dalam meningkatkan derajat kesehatan mereka.
Sosialisasi Marketing Plan Dengan Digital Marketing Untuk Meningkatkan Pemanfaatan Rawat Inap di Puskesmas Gempol
Authors: Rakhmawati Fitria
Published: April 2023

This community service activity has the aim of restoring the trust and interest of the Gempol community to return to utilizing inpatient services at the Gempol Health Center. The COVID-19 pandemic has created feelings of fear and anxiety in the community; this is the cause of the problem of decreasing interest in utilizing inpatient services at the Gempol Health Center. To overcome this issue, it can be circumvented by making marketing strategies, both directly and by digitalization. The method of socialization that we do is through presentations and discussions about SOP and animated videos used in marketing strategies. The results were achieved in the form of changes in perception and increased interest in the use of inpatient services for BPJS patients at Gempol Health Center.
Profil Kesehatan Dasar Lansia Melalui Pemeriksaan Tekanan Darah Dalam Rangka Peringatan Hari Lanjut Usia Nasional di BKKKS Jatim
Authors: Rustam Muh Zul Azhri , Susanti Ari , Amalia Nuke , Riestyowati Maya Ayu
Published: April 2023

Elderly is someone who has reached the age of 60 years and over. The older you get, the greater the risk for experiencing health problems, because of the degenerative process. The most common degenerative disease that affects the elderly is hypertension. The purpose of this study was to determine the basic health profile of the elderly through blood pressure checks in commemoration of the National Elderly Day in East Java Social Welfare Activities Coordinating Board (BKKKS). Methods This research was conducted in three stages, namely preparation, implementation and evaluation using an accidental sampling of 125 elderly participants. The results Most of the elderly participants had normal blood pressure as much as 51.20% compared to those with hypertension as much as 48.8%, because before doing the blood pressure check, they had physical activities such as morning exercise together. Most of the elderly have normal blood pressure
Pemahaman Vaksin Covid-19 Pada Mahasiswa Lulusan Pertama Barunawati Semarang
Authors: Aryani Lenci
Published: April 2023

The Covid-19 vaccination provides immunity to society as a whole. This is very vulnerable in school children who have face-to-face activities in class, the immune level of students and teachers must be maximized. Objectives: this service is to provide a level of understanding of vaccination activities for school students. Methods: Carried out by giving a pre-test to junior high school students related to the covid-19 vaccination, followed by the delivery of material and after that a post-test is given to determine understanding related to the material provided. Results: The pre-test showed that the average knowledge of students was 12.67%. Then there was an increase in students' knowledge of vaccination by 14.13%. Conclusioins: there is an increase in students' knowledge of the use of vaccination in the school environment
Sosialisasi Rekam Medis dan Pencegahan Duplikasi Rekam Medis Pada Petugas Admisi Rumah Sakit Umum Anwar Medika
Authors: Laila Nisful , Huda Nurul , Arwani Arwani
Published: April 2023

Improving the quality of human resources is closely related to education because education is the main effort that will be able to make human resources of high quality. Education will be successful if the condition of human resources is maintained in good health, therefore health is also an important factor to support efforts to improve the quality of human resources. Admissions must increase their knowledge and skills about medical records so that they can carry out their duties professionally and understand their role optimally. minimize duplication of medical record numbers.  The method used is health socialization and promotion by informants who have been selected according to the admissions office as the respondent.  the results obtained are the priority problems that occur in the numbering of medical record files. The problem that occurs in the numbering of medical record files is human error in employees who sometimes forget or are not careful in checking patient data in hospital applications (EHOS) which makes patient data not appear in application databases and computers which sometimes long and difficult to access when inputting medical record numbers and also patients who sometimes forget to bring their identity cards, causing missed communication to admissions officers, with fishbone diagrams and 5 whys, the root cause of the problem has been found, namely the lack of accuracy of admissions staff in inputting data, computers that are old and difficult to access as well as patients who forget to bring their identity cards which make the service long. 43 Solving the problem that must be done is to provide guidance or procedures to the admissions officer on how to check the hospital application (EHOS), strengthen human resources to be more thorough, and check repeatedly when registering a patient then if duplication has already occurred then the admissions officer must coordinate with the medical record officer to deactivate one of the medical record numbers that have not been registered for a long time and replace it with a newer one