bluuebunny/crossref_metadata_2025 huggingface dataset:
Developing an accurate empirical correlation for predicting anti-cancer drugs’ dissolution in supercritical carbon dioxide
Authors: Faress Fardad , Yari Amin , Rajabi Kouchi Fereshteh , Safari Nezhad Ava , Hadizadeh Alireza , Sharif Bakhtiar Leili , Naserzadeh Yousef , Mahmoudi Niloufar
Published: June 2022

This study introduces a universal correlation based on the modified version of the Arrhenius equation to estimate the solubility of anti-cancer drugs in supercritical carbon dioxide (CO2). A combination of an Arrhenius-shape term and a departure function was proposed to estimate the solubility of anti-cancer drugs in supercritical CO2. This modified Arrhenius correlation predicts the solubility of anti-cancer drugs in supercritical CO2 from pressure, temperature, and carbon dioxide density. The pre-exponential of the Arrhenius linearly relates to the temperature and carbon dioxide density, and its exponential term is an inverse function of pressure. Moreover, the departure function linearly correlates with the natural logarithm of the ratio of carbon dioxide density to the temperature. The reliability of the proposed correlation is validated using all literature data for solubility of anti-cancer drugs in supercritical CO2. Furthermore, the predictive performance of the modified Arrhenius correlation is compared with ten available empirical correlations in the literature. Our developed correlation presents the absolute average relative deviation (AARD) of 9.54% for predicting 316 experimental measurements. On the other hand, the most accurate correlation in the literature presents the AARD = 14.90% over the same database. Indeed, 56.2% accuracy improvement in the solubility prediction of the anti-cancer drugs in supercritical CO2 is the primary outcome of the current study.
Clinical outcomes of severe sepsis and septic shock patients with left ventricular dysfunction undergoing continuous renal replacement therapy
Authors: Yu Guangwei , Cheng Kun , Liu Qing , Wu Wenwei , Hong Huashan , Lin Xiaohong
Published: June 2022

Baseline left ventricular (LV) dysfunction is associated with subsequent risks of acute kidney injury (AKI) and mortality in patients with sepsis. This study investigated the therapeutic effects of continuous renal replacement therapy (CRRT) in hemodynamically unstable patients with severe sepsis and septic shock combined with LV dysfunction. In this multicenter retrospective study, severe sepsis and septic shock patients with LV dysfunction were classified into one of two groups according to the timing of CRRT: the early group (before AKI was detected) or the control group (patients with AKI). Patients from the control group received an accelerated strategy or a standard strategy of CRRT. The primary outcome was all-cause intensive care unit (ICU) mortality. Patients were weighted by stabilized inverse probability of treatment weights (sIPTW) to overcome differences in baseline characteristics. After sIPTW analysis, the ICU mortality was significantly lower in the early group than the control group (27.7% vs. 63.5%, p < 0.001). Weighted multivariable analysis showed that early CRRT initiation was a protective factor for the risk of ICU mortality (OR 0.149; 95% CI 0.051–0.434; p < 0.001). The ICU mortality was not different between the accelerated- and standard-strategy group (52.5% vs. 52.9%, p = 0.970). Early CRRT in the absence of AKI is suggested for hemodynamically unstable patients with severe sepsis and septic shock combined with LV dysfunction since it benefits survival outcomes.
Longitudinal auditory data of children with prelingual single-sided deafness managed with early cochlear implantation
Authors: Arras Tine , Boudewyns An , Swinnen Freya , Zarowski Andrzej , Philips Birgit , Desloovere Christian , Wouters Jan , van Wieringen Astrid
Published: June 2022

Individuals with single-sided deafness (SSD) have no access to binaural hearing, which limits their ability to localize sounds and understand speech in noisy environments. In addition, children with prelingual SSD are at risk for neurocognitive and academic difficulties. Early cochlear implantation may lead to improved hearing outcomes by restoring bilateral hearing. However, its longitudinal impact on the development of children with SSD remains unclear. In the current study, a group of young children with prelingual SSD received a cochlear implant at an early age. From the age of four, the children’s spatial hearing skills could be assessed using a spatial speech perception in noise test and a sound localization test. The results are compared to those of two control groups: children with SSD without a cochlear implant and children with bilateral normal hearing. Overall, the implanted group exhibited improved speech perception in noise abilities and better sound localization skills, compared to their non-implanted peers. On average, the children wore their device approximately nine hours a day. Given the large contribution of maturation to the development of spatial hearing skills, further follow-up is important to understand the long-term benefit of a cochlear implant for children with prelingual SSD.
Echo chambers and information transmission biases in homophilic and heterophilic networks
Authors: Diaz-Diaz Fernando , San Miguel Maxi , Meloni Sandro
Published: June 2022

We study how information transmission biases arise by the interplay between the structural properties of the network and the dynamics of the information in synthetic scale-free homophilic/heterophilic networks. We provide simple mathematical tools to quantify these biases. Both Simple and Complex Contagion models are insufficient to predict significant biases. In contrast, a Hybrid Contagion model—in which both Simple and Complex Contagion occur—gives rise to three different homophily-dependent biases: emissivity and receptivity biases, and echo chambers. Simulations in an empirical network with high homophily confirm our findings. Our results shed light on the mechanisms that cause inequalities in the visibility of information sources, reduced access to information, and lack of communication among distinct groups.
An alternative, low-dissolution counter electrode to prevent deceptive enhancement of HER overpotential
Authors: Hasan Menna M. , Allam Nageh K.
Published: June 2022

Electrochemical hydrogen evolution reaction (HER) is typically studied in three-electrode system. In this system, several counter electrodes are commonly used to ensure fast kinetics, including Pt, gold, and glassy carbon. However, the extensive application of such electrodes has raised caveats on the contribution of the redox-active species dissolving from such electrodes and redepositing on the surface of the working electrode to the measured overpotential. Consequently, this has been frequently confused with the actual electrochemical signature of the working electrode catalyst, resulting in a deceptive enhancement in the recorded overpotential. This issue becomes more critical when the electrolysis measurements involve an activation step, necessitating the need for alternative counter electrodes that are stable, especially in acidic medium, which is commonly used as the electrolyte in HER studies. Herein, while we systematically unveil such problems, an alternative counter electrode that overcomes those problems is demonstrated. Specifically, the correlation between the working electrode area to that of the counter electrode, the dissolution rate of the counter electrode, and the potential range used in the activation/cleaning of the surface on accelerating the dissolution rate is explored and discussed in detail. Finally, commercial Ti mesh is demonstrated as an alternative emerging counter electrode, which is proven to be very stable and convenient to study the HER in acidic media.
Metagenomic profiles of the early life microbiome of Indonesian inpatient neonates and their influence on clinical characteristics
Authors: Amandito Radhian , Malik Amarila , Rohsiswatmo Rinawati
Published: June 2022

Determining the initial normal neonatal gut microbiome is challenging. The debate regarding the sterile fetal environment is still ongoing. Therefore, studying and comparing normal and dysbiotic microbiomes requires the elucidation of both the fetal and infant microbiomes. Factors influencing the normal microbiome also include regional and genetic factors specific to different countries. Determining the normal microbiome population in our center and their association with the clinical conditions of infants is helpful as a tool for both the prevention and treatment of related diseases during neonatal care. Here, we employed metagenomic sequencing to characterize meconium and the subsequent early-life gut microbiome of preterm neonates in Jakarta, Indonesia. Microbiome diversity and complexity was higher in the meconium and on day 4 than on day 7. At the genus level, the most abundant genus overall was unidentified Enterobacteriaceae, with meconium samples dominated by Ureaplasma, day 4 fecal samples dominated by Staphylococcus, and day 7 samples dominated by Clostridiales, while at the phylum level the most abundant was Proteobacteria and Firmicutes. Perinatal factors of PROM and mother’s diet influenced the meconium microbiome, while day 4 and day 7 microbiome was associated with bacteremia and early administration of antibiotics. One of our sample sets was derived from triplets, and they had varying diversity despite being triplets. These data are valuable for understanding the formation of a healthy microbiome specific to neonates and devising a strategy to improve both the gut health and related clinical outcomes of the neonate.
Effect of heat treatment with different heat transfer modes on the polymerization of tosylate-doped poly(3,4-ethylenedioxythiophene) films
Authors: Kim Hyeong Jun , Jeon Jei Gyeong , Lee Ju Hwan , Kim Ju Hyeon , Lee Junho , Shin Gilyong , Kang Tae June
Published: June 2022

In this work, tosylate-doped poly(3,4-ethylenedioxythiophene) (PEDOT:Tos) films are prepared by thermally assisted oxidative polymerization either on a hot plate or in a convection oven. The main difference between these heat treatments is the way heat is transferred (conduction or convection) during polymerization. The surface morphology and structure, doped state, chemical composition, and the changes in the physical and chemical properties of the differently heat-treated films are analyzed using various instrumental methods. The hot plate-treated films exhibit a smooth and dense surface morphology with a low root-mean-square roughness of ~ 5 nm. The films have a quinoid-prevalent thiophene structure with a high electrical conductivity of 575 S/cm. By contrast, the oven-treated films show a rough and porous morphology with a surface roughness ranging from 30 to 80 nm depending on the scanning area, which yields high absorption capacity of more than 90% in the near-infrared range. The oven-treated films show a benzenoid-prevalent structure that provides relatively low electrical conductivity of 244 ± 45 S/cm. As a demonstration of these noticeable changes, PEDOT:Tos films are examined as a photothermal conversion layer to convert light energy to thermal energy, which is converted to electrical energy using a thermoelectric device by covering the films on the device.
Improving the performance of mini-channel heat sink by using wavy channel and different types of nanofluids
Authors: Saadoon Zahraa H. , Ali Farooq H. , Hamzah Hameed K. , Abed Azher M. , Hatami M.
Published: June 2022

The combination of nano fluid and changing cross-section mini-channel heat sink effects have become a remarkable choice for the use of thermal devices such as miniature electronic devices to be effectively cooled. In this paper, the comparison of three dimensional straight and wavy channel configuration with using different types nano fluids are numerically investigated. The effects of wave amplitude and A particular type of volume fraction of (Copper Oxide CuO, Dimond Al2O3, Iron Oxide Fe3O4, Titanium Oxide TiO2 and Silver Ag-nano fluids are offered. Three amplitudes of waves (0.15 mm, 0.2 mm and 0.25 mm) and Reynold’s number from 200 to 1000 and concentration volume varieties from 0 to 0.075 are used. The effect on thermal resistance, pressures drop, factor of friction of the mini channel is displayed. It is observed that the mini-channel sink's heat transfer efficiency is greatly enhanced compared to the straight channel in an event of adding distilled water as accoolant. The results indicate that nano fluid and wavy mini-channel can boost the heat sink's hydrothermal efficiency and Ag- water nano fluid in term of heat transfer, it outperforms other nanofluids an enhancement in the Nusselt number reached to 54% at concentration volume 0.075.
zmm28 transgenic maize increases both N uptake- and N utilization-efficiencies
Authors: Fernandez Javier A. , Habben Jeffrey E. , Schussler Jeffrey R. , Masek Tim , Weers Ben , Bing James , Ciampitti Ignacio A.
Published: June 2022

Biotechnology has emerged as a valuable tool in the development of maize (Zea mays L.) hybrids with enhanced nitrogen (N) use efficiency. Recent work has described the positive effects of an increased and extended expression of the zmm28 transcription factor (Event DP202216) on maize yield productivity. In this study, we expand on the previous findings studying maize N uptake and utilization in DP202216 transgenic hybrids compared to wild-type (WT) controls. Isotope 15N labeling demonstrates that DP202216 hybrids have an improved N uptake during late-vegetative stages (inducing N storage in lower leaves of the canopy) and, thus, N uptake efficiency (N uptake to applied N ratio) relative to WT. Through both greater N harvest index and reproductive N remobilization, transgenic plants were able to achieve better N utilization efficiency (yield to N uptake ratio). Our findings suggest the DP202216 trait could open new avenues for improving N uptake and utilization efficiencies in maize.
Dynamics of collective modes in an unconventional charge density wave system BaNi2As2
Authors: Pokharel Amrit Raj , Grigorev Vladimir , Mejas Arjan , Dong Tao , Haghighirad Amir A. , Heid Rolf , Yao Yi , Merz Michael , Le Tacon Matthieu , Demsar Jure
Published: June 2022

BaNi2As2 is a non-magnetic analogue of BaFe2As2, the parent compound of a prototype pnictide high-temperature superconductor, displaying superconductivity already at ambient pressure. Recent diffraction studies demonstrated the existence of two types of periodic lattice distortions above and below the triclinic phase transition, suggesting the existence of an unconventional charge-density-wave (CDW) order. The suppression of CDW order upon doping results in a sixfold increase in the superconducting transition temperature and enhanced nematic fluctuations, suggesting CDW is competing with superconductivity. Here, we apply time-resolved optical spectroscopy to investigate collective dynamics in BaNi2As2. We demonstrate the existence of several CDW amplitude modes. Their smooth evolution through the structural phase transition implies the commensurate CDW order in the triclinic phase evolves from the high-temperature unidirectional incommensurate CDW, and may indeed trigger the structural phase transition. Excitation density dependence reveals exceptional resilience of CDW against perturbation, implying an unconventional origin of the underlying electronic instability.
Photo-induced ligand substitution of Cr(CO)6 in 1-pentanol probed by time resolved X-ray absorption spectroscopy
Authors: Mascarenhas Eric J. , Fondell Mattis , Büchner Robby , Eckert Sebastian , Vaz da Cruz Vinícius , Föhlisch Alexander
Published: June 2022

The photo-induced ligand substitution reaction of Cr(CO)6 in 1-pentanol was investigated using time-resolved X-ray absorption spectroscopy. The results point to ligand rearrangement after photoexcitation.
Mixed valency in a neutral 1D Fe-chloranilate coordination polymer
Authors: Clutterbuck Katelyn M. , Abrahams Brendan F. , Hudson Timothy A. , van Koeverden Martin P.
Published: June 2022

A neutral Fe-chloranilate chain, with triphenylphosphine oxide co-ligands, represents a rare example of a one-dimensional chain in which there is a temperature dependent electron transfer from the Fe(ii) centre to the bridging chloranilate ligand.
Antifibrotic effect of AD-1 on lipopolysaccharide-mediated fibroblast injury in L929 cells and bleomycin-induced pulmonary fibrosis in mice
Authors: Li Tao , Chen Yu , Li Yuan , Chen Gang , Zhao Yuqing , Su Guangyue
Published: June 2022

AD-1 has an anti-PF effect and its anti-PF mechanism may be related to its anti-inflammatory and antioxidant effects, and to its capacity to inhibit apoptosis and regulate the TGF-β1/TIMP-1/α-SMA signaling pathway.
Functionalized boron nanosheets with near-infrared-triggered photothermal and nitric oxide release activities for efficient antibacterial treatment and wound healing promotion
Authors: Lv Jialin , Qi Ye , Tian Yiming , Wang Guangyao , Shi Lei , Ning Guiling , Ye Junwei
Published: June 2022

A multifunctional nanoplatform has been developed based on boron nanosheets loaded quaternized chitosan and NO donor N,N′-di-sec-butyl-N,N′-dinitroso-1,4-phenylenediamine for rapid, and effective treatment of pathogenic bacteria.
Learning the laws of lithium-ion transport in electrolytes using symbolic regression
Authors: Flores Eibar , Wölke Christian , Yan Peng , Winter Martin , Vegge Tejs , Cekic-Laskovic Isidora , Bhowmik Arghya
Published: June 2022

Machine learning to discover equations: we train a symbolic regression model on high-throughput experimental data and find an explainable, simple and accurate analytical expression predicting the ionic conductivity of a Li-ion battery electrolyte.
Exploring the synergistic effect of alloying toward hydrogen evolution reaction: a case study of Ni3M (M = Ti, Ge and Sn) series
Authors: Zhang Dong , Ji Shen-Jing , Cao Yu , Suen Nian-Tzu
Published: June 2022

In this work, we have demonstrated that one can control the intrinsic activity of Ni metal toward the hydrogen evolution reaction (HER) by simply alloying Ni with different elements (i.e. Ti, Ge or Sn).
Red room temperature phosphorescence of lead halide based coordination polymer showing efficient angle-dependent polarized emission and photoelectric performance
Authors: Tian Xu-Ke , Zhang Ji-Rui , Wen Meng-Yao , Liu Zi-Han , Guo Jia-hui , Ma Cheng-Yu , Zhang Hao-Yi , Yang Xiao-Gang , Ma Lu-Fang
Published: June 2022

A coordination polymer exhibiting rare example of red room-temperature phosphorescence has been synthesized. The alternating arrangement of electronic donor–acceptor at molecular level enables high electrochemistry and photovoltaic active.
Atmospheric atomic layer deposition of SnO2 thin films with tin(ii) acetylacetonate and water
Authors: Nguyen Viet Huong , Akbari Masoud , Sekkat Abderrahime , Ta Huong T. T. , Resende Joao , Jiménez Carmen , Musselman Kevin P. , Muñoz-Rojas David
Published: June 2022

Our work presents a new process for the spatial atomic layer deposition (SALD) of SnO2 thin films from tin(ii) acetylacetonate and water, supported by a DFT study of different Sn metalorganic precursors.
Evaluating the mechanism of milk protein as an efficient lignin blocker for boosting the enzymatic hydrolysis of lignocellulosic substrates
Authors: Huang Caoxing , Lin Wenqian , Zheng Yayue , Zhao Xiaoxue , Ragauskas Arthur , Meng Xianzhi
Published: June 2022

The residual lignin in pretreated biomass significantly hinders the bio-conversion of cellulose into monosaccharides.
Automated sample-to-answer centrifugal microfluidic system for rapid molecular diagnostics of SARS-CoV-2
Authors: Malic Lidija , Brassard Daniel , Da Fonte Dillon , Nassif Christina , Mounier Maxence , Ponton André , Geissler Matthias , Shiu Matthew , Morton Keith J. , Veres Teodor
Published: June 2022

A rapid, fully automated, sensitive and specific SARS-CoV-2 detection method using RT-LAMP is performed on a centrifugal platform with active pneumatic pumping, a disposable, all-polymer-based microfluidic cartridge and lyophilized reagents.
Chemistry of 2-vinylindoles: synthesis and applications
Authors: Elshaier Yaseen A. A. M. , Nemr Mohamed T. M. , Refaey Mohamed S. , Fadaly Wael A. A. , Barakat Assem
Published: June 2022

In this review we shed the light of the chemistry of 2-vinylindoles, synthesis and application via metal coupling catalysis as a green approach.
Insights on hydrogen spillover on carbonaceous supports
Authors: Moyal Adi M. , Paz-Tal Ofra , Ben-Yehuda Eyal , Moretto Pietro , Bielewski Marek , Napolitano Emilio , Gozin Michael , Pevzner Svetlana
Published: June 2022

Novel method to prove H spillover: distribution of the hydrogenation products. CNTs improve the reaction rate by increasing the travel distance of H-atoms. C60 promotes recombination of H-atoms to molecular H2 and decreases H-availability.
Colloidal synthesis of nanoparticles: from bimetallic to high entropy alloys
Authors: Moreira Da Silva Cora , Amara Hakim , Fossard Fédéric , Girard Armelle , Loiseau Annick , Huc Vincent
Published: June 2022

A unique approach based on the colloidal route allowing the synthesis of monodisperse bimetallic, trimetallic, tetrametallic and pentametallic nanoparticles with diameters around 5 nm as solid solutions.
CuCl-photocatalyzed C–H amination of benzoxazoles
Authors: Li Guan-Nan , Li Hao-Cong , Lu Zhan , Yu Bing
Published: June 2022

The direct coupling of benzoxazoles and amines was realized by visible light irradiation and CuCl catalysis with air as an oxidant.
RAFT dispersion polymerization induced self-assembly (PISA) of boronic acid-substituted acrylamides
Authors: Dhiraj Harpal S. , Ishizuka Fumi , Elshaer Amr , Zetterlund Per B. , Aldabbagh Fawaz
Published: June 2022

For the unprotected monomer, the boroxine core of nanoparticles allows transitions to higher order morphologies, while worms and vesicles are yielded directly from PISA of the pinacol ester-protected monomer.
Arylations with nitroarenes for one-pot syntheses of triaryl-methanols and tetraarylmethanes
Authors: Li Jie , Zou Dong , Wang Bo , İşcan Ayşegül , Jin Huimin , Chen Lingfeng , Zhou Fan , Walsh Patrick J. , Liang Guang
Published: June 2022

Triarylmethanols are well-known core structures in natural products and pharmacologically relevant compounds.
A novel construct of an electrochemical acetylcholinesterase biosensor for the investigation of malathion sensitivity to three different insect species using a NiCr2O4/g-C3N4 composite integrated pencil graphite electrode
Authors: Bilal Sehrish , Nasir Muhammad , Hassan M. Mudassir , Rehman Muhammad Fayyaz ur , Sami Amtul Jamil , Hayat Akhtar
Published: June 2022

An innovative electrochemical assay has been established to determine pesticide sensitivity against acetylcholinesterase and possible toxicity against insects. The analytical efficiency of three common insect AChEs was determined through this method.
EIS analysis of the electrochemical characteristics of the metal–water interface under the effect of temperature
Authors: Sun Funan , Peng Xiao , Bai Xiangling , Chen Zhiwei , Xie Ruizhen , He Bin , Han Pengju
Published: June 2022

The mathematical model of impedance response and the equivalent circuit model is determined based on electrochemical kinetics theory, and a method for calculating the kinetic parameters of the metal interface is presented.
Novel derivatives of eugenol as potent anti-inflammatory agents via PPARγ agonism: rational design, synthesis, analysis, PPARγ protein binding assay and computational studies
Authors: Anjum Noor Fathima , Shanmugarajan Dhivya , Shivaraju Vasanth Kumar , Faizan Syed , Naishima Namburu Lalitha , Prashantha Kumar B. R. , Javid Saleem , Purohit Madhusudan N.
Published: June 2022

Rational design, synthesis, analysis, PPARγ protein binding assay and computational studies of novel eugenol derivatives.
Efficient conversion of lactic acid to alanine over noble metal supported on Ni@C catalysts
Authors: Xin Haosheng , Xiu Zhongxun , Liu Shijun , Wang Haiyong , Wang Chenguang , Ma Longlong , Liu Qiying
Published: June 2022

Lactic acid can be converted into alanine with a high selectivity of 91.4% over Ru/Ni@C catalysts.
Template assisted preparation of silicone (polydimethylsiloxane) elastomers and their self-cleaning application
Authors: Ding Xiaohong , Chen Biya , Li Muchang , Liu Ruilai , Zhao Jinyun , Hu Jiapeng , Fu Xingping , Tong Yuejin , Lu Hanqing , Lin Jing
Published: June 2022

The formation of self-cleaning functions on silicone elastomers is crucial for practical applications but still challenging.
Near-perfect spectrally-selective metasurface solar absorber based on tungsten octagonal prism array
Authors: Xu Mingpan , Guo Lin , Zhang Pengfei , Qiu Yu , Li Qing , Wang Jikang
Published: June 2022

A metamaterial absorber that can achieve near-perfect spectral selectivity with simple structure is proposed for high-temperature solar energy harvesting.
The oxygen-resistant [FeFe]-hydrogenase CbA5H harbors an unknown radical signal
Authors: Heghmanns Melanie , Rutz Andreas , Kutin Yury , Engelbrecht Vera , Winkler Martin , Happe Thomas , Kasanmascheff Müge
Published: June 2022

Electron paramagnetic resonance spectroscopy revealed an unprecedented radical species in the oxygen-resistant [FeFe]-hydrogenase CbA5H. Analysis of the isotope-sensitive data suggests that it is related to the active site, the H-cluster.
Switchable photocatalysis for the chemodivergent benzylation of 4-cyanopyridines
Authors: Georgiou Eleni , Spinnato Davide , Chen Kang , Melchiorre Paolo , Muñiz Kilian
Published: June 2022

We report a photocatalytic strategy for the chemodivergent radical benzylation of 4-cyanopyridines. The chemistry uses a single photoredox catalyst to generate benzyl radicals upon N–F bond activation of 2-alkyl N-fluorobenzamides.
The impact of physical-chemistry on film thinning in surface bubbles
Authors: Pasquet Marina , Boulogne François , Sant-Anna Julien , Restagno Frédéric , Rio Emmanuelle
Published: June 2022

In this paper, we investigate the thinning dynamics of evaporating surfactant-stabilised surface bubbles by considering the role of physical-chemistry of solutions used in a liquid bath.
Fabrication of a tunable photothermal actuator via in situ oxidative polymerization of polydopamine nanoparticles in hydrogel bilayers
Authors: Lee Chaewon , Park Jin Hyeok , Kim Mina , Kim Jong Sik , Shim Tae Soup
Published: June 2022

In situ oxidative polymerization of polydopamine in a hydrogel matrix enables tunable photothermal actuation of a hydrogel actuator.
Multiple strategies to control the hydrophilic–hydrophobic balance of P(DMA-co-DMAEMA-co-QDMAEMA) coatings
Authors: Chen Jiao , Wang Hanhan , Liu Xing , Han Xia , Liu Honglai
Published: June 2022

The regulation of the hydrophilic–hydrophobic balance of polymers has an important influence on their aggregation behavior in aqueous solution, their adhesion properties on the substrate surface, and the applications of the modified surfaces.
Photothermal-healing, and record thermal stability and fire safety black phosphorus–boron hybrid nanocomposites: mechanism of phosphorus fixation effects and charring inspired by cell walls
Authors: Zou Bin , Qiu Shuilai , Zhou Yifan , Qian Ziyan , Xu Zhoumei , Wang Jingwen , Xiao Yuling , Liao Can , Yang Wenhao , Han Longfei , Chu Fukai , Song Lei , Gui Zhou , Hu Yuan
Published: June 2022

Inspired by the structure and good thermal resistance of cell walls in plants, we herein develop a life-cycle safe multifunctional nanocomposite of PC/BP–B, achieving record fire safety and thermal stability via phosphorus fixation effects.
Broadband white-light emission from a novel two-dimensional metal halide assembled by Pb–Cl hendecahedrons
Authors: Chen Runan , Gu Hao , Han Ying , Yin Jun , Xing Guichuan , Cui Bin-Bin
Published: June 2022

The abundant selection of organic molecules and inorganic units has allowed for the fabrication of organic–inorganic hybrid metal halides (OIMHs) of various morphologies and crystal structures with controllable molecular dimensions and unique photoelectric properties.
A proteostasis network safeguards the chloroplast proteome
Authors: Llamas Ernesto , Pulido Pablo
Published: June 2022

Several protein homeostasis (proteostasis) pathways safeguard the integrity of thousands of proteins that localize in plant chloroplasts, the indispensable organelles that perform photosynthesis, produce metabolites, and sense environmental stimuli. In this review, we discuss the latest efforts directed to define the molecular process by which proteins are imported and sorted into the chloroplast. Moreover, we describe the recently elucidated protein folding and degradation pathways that modulate the levels and activities of chloroplast proteins. We also discuss the links between the accumulation of misfolded proteins and the activation of signalling pathways that cope with folding stress within the organelle. Finally, we propose new research directions that would help to elucidate novel molecular mechanisms to maintain chloroplast proteostasis.
Unconventional R proteins in the botanical tribe Triticeae
Authors: Athiyannan Naveenkumar , Aouini Lamia , Wang Yajun , Krattinger Simon G.
Published: June 2022

Plant immunity is triggered following the perception of pathogen-derived molecules by plant receptor proteins. Two protein families, membrane-localized receptor-like kinases (RLK) and intracellular nucleotide-binding leucine-rich repeat (NLR) receptors, play key roles in pathogen perception and in the initiation of downstream signaling cascades that lead to defense responses. In addition to RLKs and NLRs, recent research has identified additional protein families that function as plant resistance (R) proteins. In particular, the botanical tribe Triticeae, which includes the globally important crop species wheat and barley, has played a significant role in the discovery of ‘unconventional’ R proteins. In this review, we will summarize the current knowledge on unconventional R genes in Triticeae and the proteins they encode. The knowledge on unconventional R proteins will not only broaden our understanding of plant–pathogen interactions but also have great implications for disease resistance breeding in crops.
Implementation Science: Increasing the Public Health Impact of Audiology Research
Authors: Studts Christina R.
Published: June 2022

Purpose:

Implementation science aims to facilitate the use of evidence-based programs, practices, and policies in routine care settings. In audiology, as in other health disciplines, there is a persistent research-to-practice gap. Improving the adoption, reach, implementation, and sustainment of effective interventions in audiology would increase their public health impact, ensuring that all individuals needing hearing health care services could benefit from innovations and evidence-based best practices. This tutorial provides an introductory overview of implementation science relevant to the field of audiology, including Internet-based practices and interventions.

Method:

Major concepts and themes of implementation science are presented, including implementation outcomes, implementation science frameworks, implementation strategies, current topics in implementation science, and study design considerations. Recent publications in audiology are highlighted to illustrate implementation science concepts and themes. The relevance of each topic to the use of evidence-based programs, practices, and policies in audiology is highlighted with reference to recent research in the field.

Conclusions:

Challenges in the widespread delivery of evidence-based audiological practices and interventions limit their public health impact. The application of implementation science principles and methods in audiology research, as demonstrated in other areas of health research, can increase our focus on ensuring that effective practices are widely available, accessible, equitable, and sustainable to improve the lives of those who need them.
Online graph learning for time‐varying graphs
Authors: Si Binqiang , Luo Dongqi , Zhu Jihong
Published: June 2022

In this paper, the is focus on the online graph learning problems in time‐varying environment. Traditional graph learning methods always assume that the underlying graph is static and that enough training data are available. However, in many real world applications, the underlying graph always changes slowly and only a small batch of data can be accessed at each time step. Under the assumption that the variation of the adjacency matrix is smooth, an online graph learning method is proposed, which improves the performance by leveraging the prior from the previous estimations. Experiments show that the proposed method performs best in both dynamic and static settings.
Ungewöhnliche „Ulkusblutung“ im Magen
Authors: Rabenstein Thomas , Dippold Joachim , Rümenapf Gerhard
Published: June 2022

Bei einer Notfall-Endoskopie eines 45-jährigen Mannes mit einer komplizierten medizinischen Vorgeschichte wurde im Magenkorpus ein kleines Ulkus in einer ca. 4 cm durchmessenden, halbkugeligen Impression gefunden. Wir entschlossen uns zu einer sofortigen Durchführung einer Angio-CT-Untersuchung von Abdomen und Thorax. Impression und Ulkus wurden durch ein teilthrombosiertes Aneurysma der Arteria lienalis verursacht. Dieses wurde sofort angiografisch mittels perkutaner transluminaler Implantation eines gecoverten Stents ausgeschaltet. Der Patient erholte sich und konnte nach 12 Tagen aus dem Krankenhaus entlassen werden. Eine Literatursuche ergab, dass in solchen Fällen der sofortige Wechsel von Endoskopie zu einem gefäßchirurgischen Eingriff die beste Option darstellt. Endoskopiker müssen die sog. „Herald-Blutung“ als solche erkennen und die weiteren diagnostischen Schritte sofort veranlassen, da eine zweite Blutung meist fatal endet. Dadurch kann die Prognose auf 20–90 % Überleben verbessert werden. Leider fühlten sich in einer aktuellen Umfrage 50 % der Gastroenterologen über diese Tatsache nicht gut informiert und hätten wahrscheinlich nicht die korrekten Entscheidungen getroffen.
Positionspapier zur Befunderhebung von Darmultraschallbefunden bei chronisch entzündlichen Darmerkrankungen
Authors: Kucharzik Torsten , Atreya Raja , Bachmann Oliver , Baumgart Daniel C. , Daebritz Jan , Helwig Ulf , Janschek Johannes , Kienle Peter , Langhorst Jost , Mudter Jonas , Schmidt Carsten , Schreyer Andreas G. , Vieth Michael , Wessling Johannes , Maaser Christian
Published: June 2022

Hintergrund Zur Diagnosestellung, Erkennung von Erkrankungskomplikationen sowie zur Verlaufskontrolle bei Patienten mit Morbus Crohn und Colitis ulcerosa wird zunehmend der Darmultraschall eingesetzt. Eine systematische Befunderhebung und Dokumentation sind wichtig, um die Qualität der Befunderstellung und die Kommunikation zwischen den Fachgruppen zu verbessern. Das vorliegende Positionspapier beschreibt die Voraussetzungen für eine optimale Befunderhebung des Darmultraschalls bei Patienten mit chronisch-entzündlichen Darmerkrankungen (CED).

Methoden Eine Experten-Konsensusgruppe bestehend aus Gastroenterologen, Radiologen, Pathologen, Kinder- und Jugend-Gastroenterologen und Chirurgen führte eine systematische Literaturrecherche durch. In einem Delphi-Verfahren wurde unter Mitgliedern des Kompetenznetzes Darmerkrankungen und der Deutschen Röntgengesellschaft (DRG) über relevante Kriterien bei der Befunderhebung von Darmultraschallbefunden abgestimmt. Die daraus resultierenden Statements wurden in einer Experten-Konsensusgruppe verabschiedet.

Ergebnis Praxisorientierte Empfehlungen für eine optimale Befunderhebung mit einer standardisierten Terminologie wurden entwickelt. Der Fokus der Erhebung lag auf der Beschreibung der Entzündungsaktivität sowie der Komplikationen bei CED. Minimale Anforderungen für eine standardisierte Befunderhebung wurden definiert.

Zusammenfassung Das vorliegende Manuskript bietet praktische Empfehlungen zur Optimierung und Vereinheitlichung der Befunderhebung bei Darmultraschall-Untersuchungen bei CED.
Perkutaner Vorhofohrverschluss nach Schlaganfall
Authors: Skurk Carsten , Häusler Karl Georg , Endres Matthias , Lewalter Thorsten , Landmesser Ulf
Published: June 2022

Der katheterbasierte Verschluss des linken Vorhofohrs stellt bei Patienten mit Vorhofflimmern, welche nicht für eine Langzeittherapie mit oralen Antikoagulanzien geeignet sind, eine potenzielle Therapieoption zur Reduktion des Schlaganfallrisikos dar. Die Weiterentwicklung der Device- und Implantationstechnik führte in den letzten Jahren zu einer Verbesserung des Sicherheitsprofils der Behandlungsmethode. Das Therapieprinzip wird durch neue Daten unterstützt, die die Wirksamkeit des operativen Verschlusses des linken Vorhofohrs zusätzlich zur Antikoagulation im Rahmen von kardiochirurgischen Eingriffen zeigen. Aktuell wird der katheterbasierte Verschluss des linken Vorhofohres in verschiedenen Patientenpopulationen in randomisierten Studien evaluiert. Die Datenlage, die Einsatzgebiete und randomisierte Studien unter besonderer Berücksichtigung der CLOSURE-AF-Studie sollen in der vorliegenden Übersichtsarbeit diskutiert werden.
Anatomical Step-by-Step Dissection of Complex Skull Base Approaches for Trainees: Surgical Anatomy of the Endoscopic Endonasal Approach to the Sellar and Parasellar Regions
Authors: Agosti Edoardo , Alexander A. Yohan , Leonel Luciano C.P.C. , Van Gompel Jamie J. , Link Michael J. , Pinheiro-Neto Carlos D. , Peris-Celda Maria
Published: June 2022

Introduction Surgery of the sellar and parasellar regions can be challenging due to the complexity of neurovascular relationships. The main goal of this study is to develop an educational resource to help trainees understand the pertinent anatomy and procedural steps of the endoscopic endonasal approaches (EEAs) to the sellar and parasellar regions.

Methods Ten formalin-fixed latex-injected specimens were dissected. Endoscopic endonasal transsphenoidal transsellar, transtuberculum-transplanum, and transcavernous approaches were performed by a neurosurgery trainee, under supervision from the senior authors and a PhD in anatomy with advanced neuroanatomy experience. Dissections were supplemented with representative case applications.

Results Endoscopic endonasal transsphenoidal approaches afford excellent direct access to sellar and parasellar regions. After a wide sphenoidotomy, a limited sellar osteotomy opens the space to sellar region and medial portion of the cavernous sinus. To reach the suprasellar space (infrachiasmatic and suprachiasmatic corridors), a transplanum-prechiasmatic sulcus-transtuberculum adjunct is needed. The transcavernous approach gains access to the contents of the cavernous sinus and both medial (posterior clinoid and interpeduncular cistern) and lateral structures of the retrosellar region.

Conclusion The anatomical understanding and technical skills required to confidently remove skull base lesions with EEAs are traditionally gained after years of specialized training. We comprehensively describe EEAs to sellar and parasellar regions for trainees to build knowledge and improve familiarity with these approaches and facilitate comprehension and learning in both the surgical anatomy laboratory and the operating room.
Discriminative Ability of Lower limb Strength and Power Measures in
Lacrosse Athletes
Authors: Talpey Scott W. , Axtell Robert , Gardner Elizabeth , Maloney Maggie , Newman Thomas , Cordone Jason , O’Grady Mathew
Published: June 2022

The objective of this investigation was to compare isokinetic strength,
countermovement jump and drop jump variables between high-contributors and
low-contributors within NCAA Division I Men’s and Women’s
lacrosse athletes. Men’s (N=36) and Women’s
(N=30) NCAA Division I lacrosse athletes completed strength testing of
the quadriceps and hamstring across three speeds
(60°·s−1,
180°·s−1,
300°·s−1), countermovement and drop
jumps. To determine the discriminative ability of select lower-limb strength and
power characteristics participants were categorized as high-contributors
(Males N=18, age=20.3±0.4 yrs,
height=183.9±5.5 cm,
mass=90.8±5.8 kg; Females N=15,
age=20.8±0.8 yrs,
height=169.3±6.7 cm,
mass=64.1±7.2 kg) or low-contributors (Males
N=18, age=19.5±0.2 yrs,
height=184.1±5.6 cm;
mass=87.9±8.1 kg; Females N=15,
age=19.7±0.2 yrs,
height=169.8±7.0 cm,
mass=62.9±7.7 kg ) based upon the number of
games the participants competed in during the regular season. Within the male
cohort, moderate significant (p<0.05) differences were observed between
high-contributors and low-contributors in isokinetic hamstring strength of the
left leg at 300°·s−1 (d=0.69) and
peak power in countermovement jump (d=0.68). Within the
women’s cohort a large (d=0.87) significant difference
(p<0.05) in isokinetic strength of the left hamstring was observed
between high-contributors and low-contributors at
60°·s−1. Hamstring strength and
lower-limb power are important strength measures for lacrosse performance and
should be prioritized in training prescription for lacrosse athletes.
Synthesis of 2,3-Diarylquinoxaline Carboxylic Acids in High-Temperature Water
Authors: Unterlass Miriam M. , Amaya-García Fabián
Published: June 2022

Aromatic carboxylic acids are prone to decarboxylate in high-temperature water (HTW). While the decarboxylation kinetics of several aromatic carboxylic acids have been explored, studies on their compatibility with organic syntheses in HTW are scarce. Herein, we report the hydrothermal synthesis (HTS) of 2,3-diarylquinoxaline carboxylic acids from 1,2-diarylketones and 3,4-diaminobenzoic acid. A detailed study of the reaction parameters was performed to identify reaction conditions towards minimal decarboxylation. Thirteen 2,3-diarylquinoxaline-6-carboxylic acids are obtained at temperatures between 150–230 °C within 5–30 minutes. The reported conditions feature comparable performance to those of classic syntheses, avoiding volatile organic solvents, strong acids and toxic catalysts. Decarboxylated quinoxalines arise as side products in variable amounts via direct decarboxylation of the 3,4-diaminobenzoic acid. To completely inhibit the decarboxylation, we show that suitable structural analogues of 3,4-diaminobenzoic acid can act as starting compounds. Thus, ester hydrolysis of methyl 3,4-diaminobenzoate and deprotection of di-Boc-protected 3,4-diminobenzoic can be coupled with the HTS of quinoxaline towards quinoxaline carboxylic acids, while fully avoiding decarboxylated side products.
Improving Medication Adherence in Asthma
Authors: Kerr Patrick J. , Brennan Vincent , Mac Hale Elaine , Doyle Frank , Costello Richard W.
Published: June 2022

In little over a generation, the ingenuity of scientists and clinician researchers has developed inhaled medications and pathway-specific biological agents that control the inflammation and physiology of asthma. Unfortunately, whether it is because of cost or difficulty understanding why or how to use inhaled medications, patients often do not take these medications. The consequences of poor treatment adherence, loss of control and exacerbations, are the same as if the condition remained untreated. Furthermore, poor adherence is difficult to detect without direct measurement. Together this means that poor treatment adherence is easily overlooked and, instead of addressing the cause of poor adherence, additional medicines may be prescribed. In other words, poor treatment adherence is a risk for the patient and adds cost to healthcare systems. In this article, we discuss the rationale for and the delivery of successful interventions to improve medication adherence in asthma. We contextualize these interventions by describing the causes of poor treatment adherence and how adherence is assessed. Finally, future perspectives on the design of new interventions are described.
Brand attachment: a review and future research
Authors: Shimul Anwar Sadat
Published: June 2022

This paper conducts an integrative review and provides a synthesisation of key themes in the brand attachment literature. A total of 171 papers were selected and analysed using a framework-based approach. In addition to exploring the theories and frameworks, this review summarises the contexts, antecedents, outcomes, mediators, and moderators of brand attachment. Based on the gaps identified in current studies, directions are provided for future brand attachment research. The review suggests that there are multiple directions in which to take the domain further. Theoretical underpinnings require conceptual clarity and consistency with attachment theory, and the development and validation of research frameworks are essential. Furthermore, the application of contextual measurements and rigorous methodologies is warranted to address the shortcomings of the current literature. The recommendations of this review are expected to facilitate advancements in brand attachment research.
Thermodynamically metastable α-, ε- (or κ-), and γ-Ga2O3: From material growth to device applications
Authors: Biswas Mahitosh , Nishinaka Hiroyuki
Published: June 2022

Gallium oxide (Ga2O3) has attracted tremendous attention in power electronics and ultraviolet photodetectors because of the large bandgap of 4.9–5.3 eV available to all polymorphs, as well as its high electric breakdown voltage. Recently, there has been increasing research interest in thermodynamically metastable phases such as α-, ε- (or κ-), and γ-Ga2O3, because they are predicted to exhibit superior properties compared with β-Ga2O3, the most stable phase of Ga2O3. For example, α-Ga2O3 (bandgap, Eg = 5.3 eV; expected breakdown field, Ec = ∼10 MV/cm) is expected to be a better potential candidate in power electronics than β-Ga2O3 (Eg = 4.5–4.8 eV; Ec = 8 MV/cm) because of its larger bandgap and higher breakdown field. Because these thermodynamically metastable phases cannot be grown using melt-growth techniques, they are grown heteroepitaxially on foreign substrates. We extensively illustrate the growth of these metastable phases and their alloys by employing various growth techniques and then discuss their doping and electronic properties. Finally, we emphasize their applications in devices, including power devices and solar-blind ultraviolet photodetectors.
Research on the methodology and instrument of traceable measurement of surface temperature based on an “ideal plane” model
Authors: Xie Zhi , Wang Junlin , Che Xunjian
Published: June 2022

Because the emissivity of a measured sample is difficult to determine in an in situ measurement and the emissivity of a pyrometer is different in the in situ measurement and calibration, the measurement results of the pyrometer are not traceable to a standard—The International Temperature Scale of 1990. To solve this problem, an ideal plane is proposed in this paper. The measured sample and the thermocouple are in a vacuum blackbody, and a gold-plated reflector is in contact with the measured sample. The surface can emit blackbody radiation during the measurement. The emissivity of the measured surface is always the same as that during calibration, so the uncertainty of emissivity is eliminated. In addition, the temperature of the measured sample is the same as that of the thermocouple in the vacuum blackbody; in doing so, the temperature differences between them are eliminated, and the uncertainty of the traceable measurement of the measured surface is greatly reduced. The instrument has been developed and tested. The results show that the average difference of traceable measurements in the range of 600–900 °C is 2.29 °C, while the uncertainty is 0.52 °C.