bluuebunny/crossref_metadata_2025 huggingface dataset:
PHISHSNAP-A Chrome Extension Tool used for Detection of Phishing applying Machine Learning
Authors: T S Arya Nadh , P Binitha , Suresh Nimmi , V S Pranaya , S Kumar Unnikrishnan
Published: April 2024

This work introduces a novel approach aimed at strengthening the effectiveness of phishing detection systems in the face of evolving cyber threats. Leveraging the power of machine learning-based anomaly detection techniques, this proposed mechanism seeks to significantly enhance both the accuracy and adaptability of current detection methods to effectively combat emerging phishing attacks. Central to this methodology is the utilization of ensemble model mechanisms, which intelligently integrate predictions from a diverse array of machine learning models. Through cautious analysis of URLs utilizing distinct datasets, this system systematically compares and contrasts results with established approaches, thereby enriching the overall detection process. This approach showcases notable improvements in performance metrics, boasting higher success rates that substantially exceed conventional heuristic analysis and blacklist-based detection methodologies. By transcending the limitations inherent in traditional detection strategies, this innovative framework represents a promising leap forward in the ongoing battle against phishing exploits, offering enhanced resilience in safeguarding sensitive user information from malicious cyber threats.
OS IMPACTOS DO CIGARRO ELETRÔNICO NA SAÚDE BUCAL: REVISÃO DE LITERATURA INTEGRATIVA
Authors: Andrade Jahnsley Lorran Santiago Vieira , Rocha Anna Karla Sampaio da , Araújo Geovanna Inácio , França Gescica Natália Matias de , Viana Larissa de Souza , Dias Marcus Vinícius Rodrigues , Santos Roberta Melo Mendes dos , Gritti Giovana Cunha , Junior José Carlos Figueiredo Fernandes , Santos Ana Paula Feitosa , Carvalho Roberta Furtado
Published: April 2024

INTRODUÇÃO: Cigarros eletrônicos (CE) são dispositivos alimentados por bateria que não queimam nem usam folhas de tabaco, mas vaporizam uma solução à base de nicotina que o usuário inala através da boca. Foram criados para substituírem os cigarros convencionais para pessoas que queriam parar de fumar, pois a cessação do tabagismo causa sintomas de abstinência, como irritabilidade, depressão, inquietação e ansiedade. OBJETIVO: Dissertar sobre o impacto do uso de cigarro eletrônico na saúde bucal dos usuários. METODOLOGIA: Foram utilizados 08 artigos publicados nas bases de dados PubMed e Biblioteca Virtual em Saúde (BVS). Os critérios para inclusão foram artigos disponíveis na língua portuguesa e inglesa, publicados entre os anos de 2018 a 2023. Os critérios de exclusão foram teses, dissertações e trabalhos de conclusão de curso. RESULTADOS E DISCUSSÃO: Os Cigarros Eletrônicos não contêm tabaco, mas contêm nicotina, que causa sensação prazerosa, redução do estresse e ansiedade, e controle do humor, além de serem saborizados. De acordo com os fabricantes de cigarros eletrônicos, um único dispositivo pode conter tanta nicotina quanto um maço de 20 cigarros convencionais. A maioria dos usuários desconhece os efeitos do uso dos dispositivos eletrônicos na saúde geral e bucal, como risco aumentado para câncer e asma, cáries, gengivite, periodontite e perdas dentárias. CONCLUSÃO: É dever do cirurgião-dentista ser capaz de avaliar, tratar e orientar seus pacientes em relação ao uso dos CE, conscientizando-os sobre seus impactos na saúde.
Strategi Personal Digital Branding Profesi Pengacara Pada lnstagram @Hotmanparisofficial
Authors: Kania Dessy , Handayani Rivi , Vida Helen Diana
Published: April 2024

Digital media, especially social networks like Instagram contributes to the emergence of a worldwide culture also known as a virtual community. The following study's goal is to define and pinpoint the personal branding tactics used by Hotman Paris to promote his legal services through social media posts on Instagram. The research method used in this research is qualitative with case study method. As a very popular and controversial lawyer, Rotman Paris not only actively uses Instagram as a medium to promote his legal services, but he also shares information and knowledge, handles a problem, informs the government of activities carried out, or even as simply greets the public through his post. Rotman Paris uses personal branding strategies by positioning himself not only as a famous lawyer but also dignified and sincere lawyer, which is shown from several posts on his personal Instagram account. Through this research, we found that Hotma11 Paris employs personal digital branding strategy which consists of factors such as: defining who you are, determining what you do, positioning yourself, and managing your brand through his Instagram account @hotmanparisofficial.
Strategi Personal Digital Branding Profesi Pengacara Pada lnstagram @Hotmanparisofficial
Authors: Kania Dessy , Handayani Rivi , Vida Helen Diana
Published: April 2024

Digital media, especially social networks like Instagram contributes to the emergence of a worldwide culture also known as a virtual community. The following study's goal is to define and pinpoint the personal branding tactics used by Hotman Paris to promote his legal services through social media posts on Instagram. The research method used in this research is qualitative with case study method. As a very popular and controversial lawyer, Rotman Paris not only actively uses Instagram as a medium to promote his legal services, but he also shares information and knowledge, handles a problem, informs the government of activities carried out, or even as simply greets the public through his post. Rotman Paris uses personal branding strategies by positioning himself not only as a famous lawyer but also dignified and sincere lawyer, which is shown from several posts on his personal Instagram account. Through this research, we found that Hotma11 Paris employs personal digital branding strategy which consists of factors such as: defining who you are, determining what you do, positioning yourself, and managing your brand through his Instagram account
EU Accession Criteria and Procedures: Up for the Challenge?
Authors: Jano Dorian
Published: April 2024

The article comprehensively analyses the evolution and challenges surrounding the criteria and procedures for accession to the European Union (EU). It traces the historical trajectory of EU accession criteria and procedures from pre- to post-Copenhagen phase. The article scrutinizes the emergence and formalization of democratic principles in EU accession and the various ongoing adjustments made to adapt to the changing circumstances, highlighting the multistep accession procedures and the introduction of flexibility, reversibility, and uncertainty into the process. While navigating the complexities of the evolving accession criteria and procedures, we address the many criticisms and plausible future developments. The article underscores the need for a return to the core normative accession criteria on democracy and the rule of law principles as a way to restore credibility and consistency in the EU accession process.
LABOR MARKET IN THE HOSPITALITY INDUSTRY: CURRENT STATE AND DEVELOPMENT TRENDS
Authors:   Peter the Great Saint-Petersburg Polytechnic University, Saint-Petersburg, Russia, Voronova Olga V. , Khnykina Tatyana S. ,   Peter the Great Saint-Petersburg Polytechnic University, Saint-Petersburg, Russia
Published: April 2024

Currently, we are witnessing significant changes in the business landscape of almost all sectors of the economy, primarily related to digital transformation, pandemic and sanctions. Despite the fact that the hospitality industry has demonstrated high flexibility and adaptability, these changes have a significant impact on the HoReCa labor market, as they directly affect the volume and structure of tourist flows. Under these conditions, the assessment of employment and labor satisfaction of the economically active population employed in the industry becomes an urgent problem of the service sector. In this regard, the object of this study is the labor market of the hospitality industry. The purpose of this research is to assess the current state and trends in the development of the labor market in the hospitality industry. To realize this goal, the main indicators of the tourism and hospitality industry development in the Russian Federation were analyzed, including the dynamics of the number of employees in the industry; the need for employees to fill vacant jobs; the ratio of the number of resumes to the number of vacancies in the market; the growth rate of the number of vacancies in the professional field of "Tourism, hotels, restaurants". As a result of this research the main problems and trends of the labor market development in the hospitality industry were identified. On the basis of the identified problems, solutions have been developed to reduce the level of turnover in the industry, mitigate the impact of seasonality on the movement of labor resources and improve their professional competencies. The obtained results can be used as a basis for the development of specific measures for the formation of internal personnel reserve of the industry. The results of the study can be used to regulate the labor market of the hospitality industry.
ASSESSMENT OF THE PREPARATION OF STUDENT MULTIPOTENTIAL TEAMS FOR PROFESSIONAL ACTIVITY
Authors:   Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russia, Vinogradova Anna V. , Kotomenkova Olga G. ,   Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russia
Published: April 2024

The authors present the results of a survey of participants in the “Turnkey Team” project, implemented in the 2022/23 academic year by the Institute of Industrial Management of Economics and Trade of Peter the Great St. Petersburg Polytechnic University, on the readiness of graduates for professional activities. The survey involved three focus groups consisting of members of multi-student teams formed from graduate students studying in the areas of training for an enlarged group of specialties “Economics and Management”, representatives of employers and team mentors from the university with whom the teams interacted during the project. Analysis of the survey results showed high consistency in assessments of teams’ readiness for professional activities, the positive role of the project in building confidence and adapting students to professional activities at enterprises in the real sector of the economy. All parties emphasize the importance of systematic work to continue the implementation of the project for training interdisciplinary teams, work to attract specialized organizations to the project and systematically work with them in terms of forming a pool of cases, assignments and relevant topics for student teams to work on. The project participants expressed wishes for the start of work on projects of student teams earlier than the final year, closer interaction within the project between all interested parties, both from the university and from the specialized enterprise. Interaction should contribute to the unity of team members at the stage of creating teams and starting work on the project; a deeper understanding of the business model of the enterprise, the specifics of its work in general and individual structural divisions in particular.
FEATURES OF THE TECHNOLOGY FOR DESIGNING GRADUATE QUALIFICATION PAPER PERFORMED BY SEVERAL STUDENTS AT THE REQUEST OF AN INDUSTRIAL PARTNER
Authors:   Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russia, Kozhina Ksenia S. , Chernikova Anna V. ,   Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russia
Published: April 2024

The article analyzes the existing types of graduate qualification paper performed by several students together, and the stages of designing such graduate work. The authors proposed a form of interaction between universities and representatives of industrial partners in the format of writing a thesis as a project, carried out on a topic received from the employer. The article presents the types of graduate qualification paper as a project, their distinctive characteristics and features of the design stages. The effects for students, industrial partners, universities and society arising from the implementation of the graduate qualification paper as a project are highlighted.
PROGRESSIVE TECHNOLOGIES IN ECONOMIC AND MANAGERIAL TRAINING OF SPECIALISTS IN MANAGEMENT
Authors:   Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russia, Abushova Ekaterina E. , Makarov Makarov, ,   Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russia, Livintsova Maria G. ,   Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russia, Simakova Zoya L. ,   Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russia
Published: April 2024

The information technologies development has led to qualitative changes in teaching people and presenting educational material to them. The paper describes problems of the formation of competencies and the requirements for the level of training of a modern manager in the context of Industry 4.0. At the same time, a great responsibility falls on educational institutions for the training of specialists corresponding to the time. The paper aims to show how blended learning using digital technologies is introduced into the educational process of the Institute of Industrial Management of Economics and Trade of Peter the Great St. Petersburg Polytechnic University, as well as to describe its further development direction.
STUDYING THE OVICIDAL PROPERTIES OF A MODIFIED SOLUTION OF SQUICK LIME IN RELATION TO ASCARID BIRD
Authors:   Caspian Zonal Scientific Research Veterinary Institute – Branch of the Federal State Budgetary Scientific Institution «FANC RD», Makhachkala, 367000, Russian Federation, Saypullayev Magomedzapir S. , Hajimuradova Zarima T. ,   Caspian Zonal Scientific Research Veterinary Institute – Branch of the Federal State Budgetary Scientific Institution «FANC RD», Makhachkala, 367000, Russian Federation, Mirzoeva Tamila B. ,   Caspian Zonal Scientific Research Veterinary Institute – Branch of the Federal State Budgetary Scientific Institution «FANC RD», Makhachkala, 367000, Russian Federation, Saypullae Umalat M. ,   Caspian Zonal Scientific Research Veterinary Institute – Branch of the Federal State Budgetary Scientific Institution «FANC RD», Makhachkala, 367000, Russian Federation
Published: April 2024

Helminths are one of the most numerous and widespread ecological groups of animals and birds. The article presents the results of studies under production conditions of the effectiveness of solutions of 20.0% – slaked lime with sodium chloride in the presence of a foaming agent – for the disinfection of roundworm eggs. The tests were carried out in premises with free-range maintenance of replacement laying hens of the KFH IP «Mugutdinova-Buynaksky district, Republic of Dagestan. Disinfestation quality control was carried out in accordance with the «Rules for Disinfection and Disinfestation of Objects of State Veterinary Supervision». Surface samples were taken by scrapings (10-15) and washes (25-30) of samples before and after disinfestation from various parts of the floor, walls, feeders, drinkers and equipment. Washings and scrapings were studied using the Fülleborn method. At the same time, it was found that solutions of a disinfestation agent, consisting of 20.0% slaked lime, 3.0% sodium chloride and 5% foaming agent, disinfected Ascaris eggs after double irrigation, with an interval of 1 hour, at the rate of 1.0 l / m2 for each irrigation, exposure – 24 hours.
THE PROBLEM OF USING PRESERVATIVES IN CHEESE MAKING
Authors:   Russian Biotechnological University, (BIOTECH University), Moscow 125080, Russian Federation, Shikhov Sergey S. , Satyukova Ludmila P. ,   Russian Biotechnological University, (BIOTECH University), Moscow 125080, Russian Federation, Sedykh Elena S. ,   Russian Biotechnological University, (BIOTECH University), Moscow 125080, Russian Federation
Published: April 2024

The article deals with the problem of the use of preservatives in the food industry, namely in cheese making. Laboratory methods for the control of preservatives are analyzed, and the choice of an analytical method for monitoring is justified. In this work, special attention was paid to benzylpenicillin, which is used as a preservative in cheese making.
FEATURES OF THE HEMATOLOGICAL PROFILE OF DOWN-CALVING AND FRESHLY CALVED COWS ON THE BACKGROUND OF THE USE OF BIOSTIMULATORS (message 1)
Authors:   All-Russian Research Institute of Veterinary Sanitation, Hygiene and Ecology – Branch of Federal Scientific Center – K. I. Skryabin, Ya. R. Kovalenko All-Russian Research Institute of Experimental Veterinary Medicine, Russian Academy of Sciences, Moscow 123022, Russian Federation, Tyurin Vladimir G. ,   Moscow State Academy of Veterinary Medicine and Biotechnology – MVA named after K. I. Skryabin, Moscow 109472, Russian Federation, Semenov Vladimir G. ,   Chuvash State Agrarian University, Cheboksary 428003, Russian Federation, Semenova Anastasia P. ,   Chuvash State Agrarian University, Cheboksary 428003, Russian Federation, Porfiriev Alexey N. ,   Chuvash State Agrarian University, Cheboksary 428003, Russian Federation, Antonov Alexey G. ,   Chuvash State Agrarian University, Cheboksary 428003, Russian Federation
Published: April 2024

The possibility of using of domestic biologics of new generation Prevention-N-A-M and PS-7 was studied in order to activate the nonspecific resistance of the animal organism. The article presents data on the morphological parameters of the blood of animals (the number of erythrocytes, leukocytes and the content of hemoglobin). The positive effect of the tested biologics on morphological parameters of blood was established. The increase of the number of erythrocytes and the concentration of hemoglobin in the blood of down-calving and freshly calved cows indicates that the introduction of biologics Prevention-N-A-M and PS-7 contributes to the activation of hematopoiesis in animals of the experimental groups. The established changes in the number of leukocytes in the blood of experimental animals on the background of intramuscular injection of biologics indicate the activation of cellular factors of nonspecific protection of the body. Data on differential leukocyte count will be presented in message 2. The results of the study make it possible to scientifically substantiate the feasibility of using biologics in animal husbandry as an effective way to increase the resistance of the body of cows, which can significantly improve their health and reduce the risk of diseases.
THE EFFECT OF FEED ADDITIVES ON THE AMINO ACID COMPOSITION OF QUAIL EGGS
Authors:   Moscow State Academy of Veterinary Medicine and Biotechnology – MVA by K.I. Skryabin, Moscow 109472, Russian Federation, Bocharova Polina A. , Bachinskaya Valentina M. ,   Moscow State Academy of Veterinary Medicine and Biotechnology – MVA by K.I. Skryabin, Moscow 109472, Russian Federation, Bachinskaya Nadezhda A. ,   All-Russian State Center for Quality and Standardization of Medicines for Animals and Feed, FGBI «VGNKI», Moscow 123022, Russian Federation
Published: April 2024

The article presents the results of studies of the amino acid composition of compound feeds and quail eggs when using vegetable feed additives based on linseed oil and fish oil in the diet. We have formed three groups of quails with 30 heads in each group of the breed «Estonian quail». Experimental groups of quails were fed feeds enriched with fish oil and linseed oil for 30 days, the control group of quails received standard compound feed. According to the results of studies we found that the introduction of fish oil and linseed oil into the composition contributed to an increase in essential amino acids by 0.84% when using fish oil and 0.66% linseed oil, partially interchangeable by 0.06% and 0.11%, respectively, and interchangeable when using linseed oil by – 0.31%.
ANCIENT CLASSIFICATIONS OF MUSICAL INSTRUMENTS
Authors: USTYUGOVA ALEXANDRA
Published: April 2024

This article discusses the basic principles of classification of musical instruments of ancient theorists. Characteristics of ancient taxonomies, features of classification principles and their relationship with Western European theoretical thought about musical instruments are given. The author comes to the conclusion that ancient classification theories had a significant influence on Western European organology, both in relation to the concepts of systematization of musical instruments and in the terminology used. The study of ancient music theory allows us to identify the origins of the ideas of Western European taxonomies and modern classifications of musical instruments.
ETHNIC TOURISM: THE VALUES AND MEANINGS OF THE ORGANIZATION IN RUSSIAN REGIONS AND ABROAD
Authors: POVETKINA ANASTASIA
Published: April 2024

The article is devoted to the peculiarities of the development of ethnic tourism in the Primorsky Territory at the present stage. Ethnic tourism today is considered as a way to preserve and popularize the ethnocultural heritage of peoples. The article characterizes the approaches to the term “ethnic tourism” of domestic and foreign researchers. It is worth noting that in the world literature the terms “aboriginal tourism” and “indigenous tourism” are found, which can be used synonymously in relation to ethnic tourism. In the domestic literature, the term “ethnic and ethnocultural tourism” is used. In world practice, unique experience has been accumulated in the development of tourism in places where indigenous peoples live. In the Russian Federation, ethnic tourism, especially in terms of indigenous peoples, is also gaining popularity. First of all, this is due to the multinationality of the state. Primorsky Krai has great potential for the development of this form of tourism. On the territory of the region, there are ethnocultural complexes, national parks, and villages where indigenous peoples live preserving their unique ethnic culture. The external attractiveness of ethnic tourism, upon deeper analysis, demonstrates features that are manifested in both the positive and negative impact of its development on the traditional culture of the Aboriginal people. The paper concludes that at the present stage of the development of ethnic tourism, there are a number of other problems that hinder its development. In the first place, this is the inaccessibility of the places of traditional residence of indigenous peoples, the underdevelopment of transport infrastructure, the consequences of the pandemic, and the ambiguous attitude of the bearers of traditional culture towards ethnic tourism.
A Methodological Discussion on Evaluating the Success of Any Securitizing Move
Authors: Çetindişli Özge Gökçen
Published: April 2024

The study objects to lay out a lucid perspective on "how any securitizing move occurs successfully" an issue that was non-rigidly theorized in the Copenhagen version of securitization, in line with current debates. To this end, the vague criteria as follows, set by the classical cadre of the Copenhagen School are problematized: actors have to couch the issue as an existential threat requiring exceptional executive powers, and, if the audience accepts the securitizing move, the case is established as a security issue beyond the routine procedure of politics. Considering this conservative cycle, the first claim of this paper is that the politics of ‟audience acceptance” is not adequately determined in theory. The second is that the classical variants’ persistence in the transition to "exceptional security policy" in the operation of securitization, ignoring its insecure nature, reduces the theory to a given and fixed understanding of security such as "security=exceptionalism." Premised on these arguments, the paper proposes an overarching systematized thought that empowers the audience’s role; does not exclude "exceptional measures" but also inserts into "normalized exceptional" and even "routine responses" as actions.
Topological Indices and Properties of the Prime Ideal Graph of a Commutative Ring and its Line Graph
Authors: Syarifudin Abdul Gazir , Muchtadi-Alamsyah Intan , Suwastika Erma
Published: April 2024

Let R be a commutative ring with identity, and P be a prime ideal of R. The prime ideal graph, denoted by Γp, is the graph where the set of vertices is R/{0} and two vertices are joined by an edge if their product belongs to P. This paper will discuss topological indices and some properties of the prime ideal graph of a commutative ring and its line graph. Topological indices, such as the Wiener, first Zagreb, second Zagreb, Harary, Gutman, Schultz, and Harmonic indices, are related to the degree of vertices and the diameter of the graphs. In this paper, we also discuss the independence and domination numbers of the line graph.
Cryptographic Signature Scheme for Mobile Edge Computing Using DLFP Over Semiring
Authors: S Sethupathi , A Manimaran
Published: April 2024

The Undeniable Signature Scheme (USS) was first introduced by chaum and van in 1989. The advantage of the (USS) scheme is the signer’s co-operation during the verification process. In this paper, the Discrete Logarithm Problem with Factor Problem (DLFP) is introduced. It’s security and complexity is analyzed. Then, based on (DLFP), a key exchange protocol is given. An undeniable signature scheme based on DLFP over semiring is proposed along with illustration we have also given application of the proposed USS in Mobile Edge Computing (MEC). Then the proposed scheme’s security and complexity is examined.
Tri-specific killer engager: unleashing multi-synergic power against cancer
Authors: Winidmanokul Peeranut , Panya Aussara , Okada Seiji
Published: April 2024

Cancer continues to be a global health concern, necessitating innovative solutions for treatment. Tri-specific killer engagers (TriKEs) have emerged as a promising class of immunotherapeutic agents, offering a multifaceted approach to cancer treatment. TriKEs simultaneously engage and activate natural killer (NK) cells while specifically targeting cancer cells, representing an outstanding advancement in immunotherapy. This review explores the generation and mechanisms of TriKEs, highlighting their advantages over other immunotherapies and discussing their potential impact on clinical trials and cancer treatment. TriKEs are composed of three distinct domains, primarily antibody-derived building blocks, linked together by short amino acid sequences. They incorporate critical elements, anti-cluster of differentiation 16 (CD16) and interleukin-15 (IL-15), which activate and enhance NK cell function, together with specific antibody to target each cancer. TriKEs exhibit remarkable potential in preclinical and early clinical studies across various cancer types, making them a versatile tool in cancer immunotherapy. Comparative analyses with other immunotherapies, such as chimeric antigen receptor-T (CAR-T) cell therapy, immune checkpoint inhibitors (ICIs), cytokine therapies, and monoclonal antibodies (mAbs), reveal the unique advantages of TriKEs. They offer a safer pathway for immunotherapy by targeting cancer cells without hyperactivating T cells, reducing off-target effects and complications. The future of TriKEs involves addressing challenges related to dosing, tumor-associated antigen (TAA) expression, and NK cell suppression. Researchers are exploring innovative dosing strategies, enhancing specificity through tumor-specific antigens (TSAs), and combining TriKEs with other therapies for increased efficacy.
Features of Delimitation of Crimes Provided for in Articles 285 of the Criminal Code and 286 of the Criminal Code when they are Committed in the Public Procurement
Authors:   St. Petersburg Law Institute (Branch), University of the Prosecutor’s Office of the Russian Federation, St. Petersburg, Russia, Shurpaev Shamil M.
Published: April 2024

The specifics of the criminal law regulation of liability for abuse of official powers and their excess committed in the field of public procurement are determined by the specifics of the regulation of the activities of officials participating in this sphere within the framework of their “procurement” and related functions. The correct qualification of acts committed in the field of public procurement requires reference to numerous regulations of the legislation on the contract system and on the procurement of goods, works, services by certain types of legal entities. The need to refer to the legislation on the contract system and on the procurement of goods, works, services by certain types of legal entities in the qualification of abuse of official powers and their excess arises when determining the content of the signs of the subject and almost all the signs of the objective side of the deed. Industry legislation in the context under consideration is characterized by high dynamism, “layering”, a significant number of contradictions and shortcomings. These circumstances determine errors and lack of uniformity in judicial practice when distinguishing crimes provided for in Articles 285 of the Criminal Code and 286 of the Criminal Code when they are committed in the field of public procurement. Homogeneous, and in some cases identical criminal actions of customer officials – violations in the pricing of goods, works, services; actions restricting competition (inaction); violations of the established procedure for concluding (changing, terminating) state and municipal contracts; violations in the acceptance of delivered goods (work performed, services rendered), etc. – may receive different criminal legal assessment. The purpose of the article is to develop recommendations and criteria for distinguishing crimes provided for in Articles 285 of the Criminal Code of the Russian Federation and 286 of the Criminal Code of the Russian Federation, taking into account the peculiarities of criminal legal assessment when committing these acts in the field of public procurement. To achieve this goal, general scientific (analysis, synthesis, induction, deduction) and private scientific (formal legal) methods of cognition were used. In the study, taking into account the recommendations of the Supreme Court of the Russian Federation, theoretical positions in the science of criminal law, the peculiarities of the legal regulation of public procurement, recommendations for distinguishing the crimes under consideration, taking into account the specifics of the situation of their commission, are formulated.
MicroRNAs in inflammatory bowel disease: What do we know and what can we expect?
Authors: Oliveira Ellen Cristina Souza de , Quaglio Ana Elisa Valencise , Grillo Thais Gagno , Di Stasi Luiz Claudio , Sassaki Ligia Yukie
Published: April 2024

MicroRNAs (miRNAs), small non-coding RNAs composed of 18–24 nucleotides, are potent regulators of gene expression, contributing to the regulation of more than 30% of protein-coding genes. Considering that miRNAs are regulators of inflammatory pathways and the differentiation of intestinal epithelial cells, there is an interest in exploring their importance in inflammatory bowel disease (IBD). IBD is a chronic and multifactorial disease of the gastrointestinal tract; the main forms are Crohn's disease and ulcerative colitis. Several studies have investigated the dysregulated expression of miRNAs in IBD, demonstrating their important roles as regulators and potential biomarkers of this disease. This editorial presents what is known and what is expected regarding miRNAs in IBD. Although the important regulatory roles of miRNAs in IBD are clearly established, biomarkers for IBD that can be applied in clinical practice are lacking, emphasizing the importance of further studies. Discoveries regarding the influence of miRNAs on the inflammatory process and the exploration of their role in gene regulation are expected to provide a basis for the use of miRNAs not only as potent biomarkers in IBD but also as therapeutic targets for the control of inflammatory processes in personalized medicine.
Mechanisms of tumor immunosuppressive microenvironment formation in esophageal cancer
Authors: Zhang Xiao-Jun , Yu Yan , Zhao He-Ping , Guo Lei , Dai Kun , Lv Jing
Published: April 2024

As a highly invasive malignancy, esophageal cancer (EC) is a global health issue, and was the eighth most prevalent cancer and the sixth leading cause of cancer-related death worldwide in 2020. Due to its highly immunogenic nature, emer-ging immunotherapy approaches, such as immune checkpoint blockade, have demonstrated promising efficacy in treating EC; however, certain limitations and challenges still exist. In addition, tumors may exhibit primary or acquired resistance to immunotherapy in the tumor immune microenvironment (TIME); thus, understanding the TIME is urgent and crucial, especially given the im-portance of an immunosuppressive microenvironment in tumor progression. The aim of this review was to better elucidate the mechanisms of the suppressive TIME, including cell infiltration, immune cell subsets, cytokines and signaling pathways in the tumor microenvironment of EC patients, as well as the downregulated expression of major histocompatibility complex molecules in tumor cells, to obtain a better understanding of the differences in EC patient responses to immunotherapeutic strategies and accurately predict the efficacy of immunotherapies. Therefore, personalized treatments could be developed to maximize the advantages of immunotherapy.
Drug-induced mucosal alterations observed during esophagogastroduodenoscopy
Authors: Iwamuro Masaya , Kawano Seiji , Otsuka Motoyuki
Published: April 2024

Several features of drug-induced mucosal alterations have been observed in the upper gastrointestinal tract, i.e., the esophagus, stomach, and duodenum. These include pill-induced esophagitis, desquamative esophagitis, worsening of gastroesophageal reflux, chemotherapy-induced esophagitis, proton pump inhibitor-induced gastric mucosal changes, medication-induced gastric erosions and ulcers, pseudomelanosis of the stomach, olmesartan-related gastric mucosal inflammation, lanthanum deposition in the stomach, zinc acetate hydrate tablet-induced gastric ulcer, immune-related adverse event gastritis, olmesartan-asso-ciated sprue-like enteropathy, pseudomelanosis of the duodenum, and lanthanum deposition in the duodenum. For endoscopists, acquiring accurate knowledge regarding these diverse drug-induced mucosal alterations is crucial not only for the correct diagnosis of these lesions but also for differential diag-nosis of other conditions. This minireview aims to provide essential information on drug-induced mucosal alterations observed on esophagogastroduodenoscopy, along with representative endoscopic images.
HISTORY OF THE FORMATION OF MILITARY PERIODICAL PRESS IN UZBEKISTAN
Authors:   Doctor of Philosophy in History (PhD), Associate Professor, Faculty of History, National University of Uzbekistan, named after Mirzo Ulugbek, Uzbekistan, Alinazarova Dildora V.
Published: April 2024

This article provides information that today military printing has become a priority in countries around the world, and now attention to this area is growing in our country. Information about the research of a group of scientists who introduced the topic of the military press into scientific circulation is covered on the basis of scientific facts and primary sources.
FEATURES OF THE GENRE «RIHLA» (TRAVEL STORY) IN ARABIC PROSE AND IT’S ROLE IN WORLD LITERATURE
Authors:   Lecturer, University of World Economy and Diplomacy, Tashkent, Uzbekistan, S. Abdunabiev
Published: April 2024

Genre Rihla attracted writers from almost all literary genres. The rihla describes the material and spiritual life of the peoples of different countries, reflects the author’s views on the history and culture of these countries, the customs and rituals of the peoples. It was this feature of the genre that attracted realist writers. The importance of the genre rihla is very great in the education of a spiritually developed person, since people who have read many works in this genre can obtain valuable information about other lands and peoples, about their history and nowadays, about geography, nature, everyday life and cultural and historical heritage, and try to appropriate their positive qualities.
Nanopartículas de óxido de zinc y óxido de plata para uso de protección solar de piel
Authors: Rojas Labastida Rodrigo Antonio , Pacheco Julián Jazmín Viridiana , Amaya Parra Guillermo , Jiménez Valera Socorro
Published: April 2024

El presente artículo, se enfoca en el uso de nanopartículas para el desarrollo de un protector solar para el cuidado de la piel, que contiene nanopartículas de óxido de zinc y nanopartículas de óxido de plata, estas nanopartículas contienen efectos antioxidantes, antimicrobianos, antiinflamatorios y cicatrizantes, empleando ZnO el cual se propone a ser sintetizado a través del método hidrotermal y las nanopartículas de Ag2O por agitación constante, a través de las  caracterizaciones como XRD, Uv-vis, Raman y medición de pH, se buscará obtener datos acerca de nuestras nanopartículas y el producto final que es un protector solar para el cuidado de la piel; las caracterizaciones aportaran datos como la fase cristalina, el grado de absorbancia, y la estructura química de las nanopartículas. De acuerdo a literatura consultada, el uso de nanopartículas de óxido de zinc decoradas con nanopartículas de óxido de plata para uso tópico, tiene propiedades para generar los efectos anteriormente mencionados (antioxidantes, antimicrobianos, antiinflamatorios y cicatrizantes). Actualmente diversos protectores solares emplean óxido de zinc y algunos otros oxido de plata, es por ello que la presente propuesta busca aplicar ambos materiales a escala nanométrica para la elaboración de una crema que, se tiene previsto, en un futuro se pueda utilizar para personas con problemas de piel, tales como la dermatitis, inclusive se plantea el poder usarlo para los diabéticos.
Eyring-Powell Fluid Flow Past a Shrinking Sheet: Effect of Magnetohydrodynamic (MHD) and Joule Heating
Authors: Iskandar Waini  , Anuar Ishak  , Ioan Pop
Published: April 2024

This paper examines the effect of magnetohydrodynamic (MHD) on Eyring-Powell fluid flow over a shrinking sheet. The sheet is permeable and it is shrunk with power-law velocity. By employing the suitable similarity transformations, the governing equations are transformed into the similarity equations, and MATLAB software is used to program the code with the aid of the bvp4c function. Results reveal that the magnetic and the suction parameters raise both the velocity and temperature gradients, which consequently increases the skin friction and the heat transfer coefficients. However, these physical quantities are reduced with the Eyring-Powell fluid parameter. The domain of the solutions is affected by the rise of the magnetic and the Eyring-Powell fluid parameters. From the stability analysis, the second solution is unstable while the first solution is stable over time.
A Numerical Investigation of the MHD Ternary Hybrid Nanofluid (Cu-Al2O3-TiO2/H2O) Past a Vertically Stretching Cylinder in a Porous Medium with Thermal Stratification
Authors: Rupam Shankar Nath  , Rudra Kanta Deka
Published: April 2024

This study focuses on examining the impact of thermal stratification on the magnetohydrodynamics (MHD) flow of water-based nano, hybrid, and ternary hybrid nanofluids past a vertically stretching cylinder in a porous medium. The nanoparticles Cu, Al2O3, and TiO2 are suspended in a base fluid H2O, leading to the formation of a ternary hybrid nanofluid Cu-Al2O3-TiO2 /H2O. The numerical results are calculated with the 3-stage Lobatto IIIa approach, specifically implemented by Bvp4c in MATLAB. The impacts of various parameters are visually depicted through graphs and quantitatively represented in tables. The velocity and temperature of the ternary hybrid nanofluid are lowered by the thermal stratification parameter compared to when there is no stratification. The ternary hybrid nanofluid has a higher heat transfer rate than the hybrid nanofluid, and the hybrid nanofluid has a higher heat transfer rate than ordinary nanofluids.
Clinical Characteristics, Diagnosis, and Treatment of Thyroid Stimulating Hormone-Secreting Pituitary Neuroendocrine Tumor (TSH PitNET): A Single-Center Experience
Authors: Heo Jung , Suh Yeon-Lim , Kim Se Hoon , Kong Doo-Sik , Nam Do-Hyun , Lee Won-Jae , Kim Sung Tae , Hong Sang Duk , Ryu Sujin , Lee You-Bin , Kim Gyuri , Jin Sang-Man , Kim Jae Hyeon , Hur Kyu Yeon
Published: April 2024

Background: Thyroid-stimulating hormone (TSH)-secreting pituitary neuroendocrine tumor (TSH PitNET) is a rare subtype of PitNET. We investigated the comprehensive characteristics and outcomes of TSH PitNET cases from a single medical center. Also, we compared diagnostic methods to determine which showed superior sensitivity.Methods: A total of 17 patients diagnosed with TSH PitNET after surgery between 2002 and 2022 in Samsung Medical Center was retrospectively reviewed. Data on comprehensive characteristics and treatment outcomes were collected. The sensitivities of diagnostic methods were compared.Results: Seven were male (41%), and the median age at diagnosis was 42 years (range, 21 to 65); the median follow-up duration was 37.4 months. The most common (59%) initial presentation was hyperthyroidism-related symptoms. Hormonal co-secretion was present in four (23%) patients. Elevated serum alpha-subunit (α-SU) showed the greatest diagnostic sensitivity (91%), followed by blunted response at thyrotropin-releasing hormone (TRH) stimulation (80%) and elevated sex hormone binding globulin (63%). Fourteen (82%) patients had macroadenoma, and a specimen of one patient with heavy calcification was negative for TSH. Among 15 patients who were followed up for more than 6 months, 10 (67%) achieved hormonal and structural remission within 6 months postoperatively. A case of growth hormone (GH)/TSH/prolactin (PRL) co-secreting mixed gangliocytoma-pituitary adenoma (MGPA) was discovered.Conclusion: The majority of the TSH PitNET cases was macroadenoma, and 23% showed hormone co-secretion. A rare case of GH/TSH/PRL co-secreting MGPA was discovered. Serum α-SU and TRH stimulation tests showed great diagnostic sensitivity. Careful consideration is needed in diagnosing TSH PitNET. Achieving remission requires complete tumor resection. In case of nonremission, radiotherapy or medical therapy can improve the long-term remission rate.
Bone Loss after Solid Organ Transplantation: A Review of Organ-Specific Considerations
Authors: Kim Kyoung Jin , Ha Jeonghoon , Kim Sang Wan , Kim Jung-Eun , Lee Sihoon , Choi Han Seok , Hong Namki , Kong Sung Hye , Ahn Seong Hee , Park So Young , Baek Ki-Hyun ,   on Behalf of Metabolic Bone Disease Study Group of Korean Endocrine Society
Published: April 2024

This review article investigates solid organ transplantation-induced osteoporosis, a critical yet often overlooked issue, emphasizing its significance in post-transplant care. The initial sections provide a comprehensive understanding of the prevalence and multifactorial pathogenesis of transplantation osteoporosis, including factors such as deteriorating post-transplantation health, hormonal changes, and the impact of immunosuppressive medications. Furthermore, the review is dedicated to organ-specific considerations in transplantation osteoporosis, with separate analyses for kidney, liver, heart, and lung transplantations. Each section elucidates the unique challenges and management strategies pertinent to transplantation osteoporosis in relation to each organ type, highlighting the necessity of an organ-specific approach to fully understand the diverse manifestations and implications of transplantation osteoporosis. This review underscores the importance of this topic in transplant medicine, aiming to enhance awareness and knowledge among clinicians and researchers. By comprehensively examining transplantation osteoporosis, this study contributes to the development of improved management and care strategies, ultimately leading to improved patient outcomes in this vulnerable group. This detailed review serves as an essential resource for those involved in the complex multidisciplinary care of transplant recipients.
Evidências e dados nas políticas públicas : o falso embate entre transparência e privacidade
Authors: Direito Denise do Carmo , Reis Fernanda Teixeira
Published: April 2024

A produção de evidência necessita do acesso a dados de qualidade, e o Estado é produtor e fornecedor relevante desses para balizar a ação pública. A manipulação dos dados – para torná-los compreensíveis para o processo analítico e decisório – utiliza ferramentas cada vez mais avançadas e complexas do ponto de vista tecnológico e estatístico. Este texto analisa políticas públicas em diferentes etapas do ciclo de implementação, apontando caminhos, riscos e limites para o estabelecimento de formas adequadas para se compatibilizar transparência – conforme normatizado pela Lei de Acesso à Informação (LAI) de 2011 – e privacidade – reafirmada na Lei Geral de Proteção de Dados Pessoais (LGPD) de 2018. Conclui-se pela necessidade de instituir mecanismos transparentes de coleta e uso de dados e, ao mesmo tempo, estabelecer tratamentos necessários, utilizando-se tecnologia e estatística avançada, como rotinas de anonimização e pseudoanonimização, para disseminarem-se dados sem renunciar à proteção dos cidadãos.