bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of the “Mengabu (Facing Ash Storms) Disaster Preparedness” Program on Adolescents’ Knowledge About Disaster Preparedness in Kresik Tuo Village, Kayu Aro District, Kerinci Regency, Jambi
Authors: Andi Subandi  , Dwi Noerjoedianto  , Elsa Volinda Sary
Published: October 2024

Natural disasters have become an integral part of people's lives in Indonesia, disrupting daily activities and causing significant impacts. Indonesia, located in the Ring of Fire, faces a high risk of volcanic eruptions, including the active Mount Kerinci which has the potential to cause disasters such as volcanic ashfall. Kresik Tuo Village, located near Mount Kerinci, faces a direct threat from this eruption. The community, especially the youth, need to improve their preparedness and knowledge to deal with potential disasters. The "MENGABU Siaga dalam Bencana" program is designed to improve the preparedness of the Kresik Tuo Village community in dealing with potential volcanic ashfall, with the hope of contributing to the development of community preparedness strategies in disaster-prone areas. To improve the knowledge of youth in Kresik Tuo Village related to disasters and disaster preparedness. The study used the Pre-Experimental research method with a Prepost Test Design. Sampling used a non-probability sampling technique with convenience sampling according to the inclusion and exclusion criteria of 40 respondents. Wilcoxon test shows that there is a significant increase in the knowledge of youth preparedness for the eruption of Mount Merapi after being given the "Mengabu Siaga dalam Bencana" program. All respondents experienced an increase in knowledge, as indicated by a positive ranks value of 40 and a p value = 0.000. Conclusion: The results of the study indicate that there is a significant effect of the "Mengabu (Mengabu Storm Ash) Siaga Dalam Bencana" Program on Youth Preparedness Knowledge for Disasters in Kresik Tuo Village, Kayu Aro District, Kerinci Regency, Jambi in increasing youth knowledge.
Antipsychotic Activity of Ethanolic Extracts of Crinum asiaticum and Crinum defixum in Animal Models
Authors:   Institute of Pharmacy & Technology, Salipur, Cuttack, Odisha-754202, India, Mishra Parthasarathi , Senapati Aswini Kumar ,   Institute of Pharmacy & Technology, Salipur, Cuttack, Odisha-754202, India, Swain Sudhansu Ranjan ,   Moradabad Educational Trust, Group of Institutions, Faculty of Pharmacy, Moradabad, U.P-244001, India, Dash Sujit ,   Institute of Pharmacy & Technology, Salipur, Cuttack, Odisha-754202, India, Kar Suchismita ,   Sri Jaydev College of Pharmaceutical Sciences, Naharkanta, Bhubaneswar, Odisha-752101, India
Published: October 2024

The current study examined the antipsychotic properties of ethanolic extracts of Crinum asiaticum (EECA) and Crinum defixum (EECD). The effects of the extracts on rodents' ketamine-induced hyperactivity, amphetamine-induced stereotypy, forced swim test, conditioned avoidance response, and catalepsy were assessed. According to the findings, EECA and EECD both significantly outperformed typical antipsychotic medications in antipsychotic-like behaviours across a variety of behavioural paradigms. The extracts exhibited a 50-75% reduction in ketamine-induced hyperactivity, indicating a possible impact on glutamatergic signalling. Additionally, they greatly reduced amphetamine-induced stereotypy, suggesting a potential antagonistic interaction with the dopamine D2 receptor. Similar to haloperidol, EECD at 400 mg/kg dramatically decreased avoidance behaviour in the conditioned avoidance response test. Though less so than with haloperidol, both extracts caused catalepsy in rodents. The reversal of ketamine's effect in the forced swim test suggests that it may be effective in preventing psychosis's negative symptoms. Given that oxidative stress is a contributing factor to psychotic disorders, the antipsychotic effect of these extracts may be associated with their anti-inflammatory and antioxidant characteristics. These results bolster the long-standing usage of Crinum species in the treatment of mental illnesses and imply that they could be rich sources of new antipsychotic chemicals. To determine the active ingredients, clarify the mechanisms of action, and assess the safety and effectiveness of clinical trials, more study is necessary.
HISTORYCZNA KOLEKCJA TRIASOWYCH LILIOWCÓW ZE ZBIORÓW MUZEUM GEOLOGICZNEGO IM. HENRYKA TEISSEYRE UNIWERSYTETU WROCŁAWSKIEGO
Authors: Płachno Bartosz J. , Niedźwiedzki Robert , Salamon Mariusz A.
Published: October 2024

W kolekcji Muzeum Geologicznego im. Henryka Teisseyre Uniwersytetu Wrocławskiego stwierdzono okazy należące do rodzajów triasowych liliowców: Dadocrinus von Meyer, 1979, Carnallicrinus Hagdorn, 2004 oraz Encrinus Lamarck, 1801. Wiele z nich zbieranych było i przekazywanych muzeum przez słynnych w XIX i XX w. paleontologów niemieckich, takich jak Ferdinand Roemer, Herman Kunisch, Johann Wysogorski czy Georg Gürich, o czym przekonują towarzyszące okazom metryczki z oryginalnymi inskrypcjami wymienianych autorów. W kolekcji wrocławskiej stwierdzono także holotyp Dadocrinus kunischi, Wachsmuth et Springer, 1886; od czasów II wojny światowej uznawany był on za zaginiony. Do jednego z okazów dołączono metryczkę sugerującą, że jest on triasowym przedstawicielem Encrinus. Obecne obserwacje wykazały jednak, że należy on do tzw. komatulidów, dokładniej bourguetikrynidów, które znane są z osadów kredowych-holocenu. Dodano, że proweniencja tego okazu jest nieznana. Wiele liliowców zachowało się w pozycji przyżyciowej, co sugeruje ich natychmiastowe pogrzebanie w osadzie tuż po śmierci. Inne zachowane są fragmentarycznie, niejednokrotnie w bardzo ciekawej pozycji, co wskazuje na ich burzliwe losy po śmierci. Te mogą stać się w przyszłości obiektem badań tafonomów czy sedymentologów. W podsumowaniu przypomniano, że liliowce triasowe mogą być doskonałym wskaźnikiem wieku oraz środowiska powstania osadów, w których zostały złożone.
PETRUS PLANCIUS I CHRISTIAN ROMSTET, CZYLI PRODUKCJA I KOPIOWANIE GLOBUSÓW W XVII WIEKU NA PRZYKŁADZIE OBIEKTU ZE ZBIORÓW MUZEUM KARKONOSKIEGO W JELENIEJ GÓRZE
Authors: Taborska Małgorzata
Published: October 2024

W Muzeum Karkonoskim w Jeleniej Górze znajduje się globus nieba, którego autor dotychczas był nierozpoznany. Dzięki analizie kartusza udało się ustalić wytwórcę, którym okazał się Christian Romstet z Lipska. Pierwowzorem był globus Petera Planciusa, wydany przez Pietera van den Keere’a w Amsterdamie w 1615 r. Plancius przygotował w XVII w. cztery pary globusów, wydane przez Pietera van den Keere’a. Wcześniej, w 1589 r. aktualizował mapę globusa nieba Jacoba van Langrena z 1586 r., natomiast w 1597/1598 r. współpracował z Jodocusem Hondiusem Starszym przy globusie nieba. Jego mapa Nova et exacta Terrarum Orbis… (1592) stanowiła podstawę przy produkcji i aktualizacji globusów Ziemi. Romstet był jednym z czterech wytwórców, którzy wydali reedycję globusów Planciusa. Korzystał z wydania z 1615 r., będącego nieaktualizowanym przedrukiem mapy z 1612 r. Romstet zaktualizował i zredagował mapę nieba do ówczesnej wiedzy astronomicznej. Przede wszystkim dodał nowe gwiazdozbiory, ustanowione przez Jana Heweliusza i Gottfrieda Kircha. Wizerunki gwiazdozbiorów zachowane są w konwencji zaproponowanej przez Gerarda Merkatora. Płyty miedziorytnicze Keere’a posłużyły Johannesowi Janssoniusowi do wydania czterech par globusów, w tym o średnicy 26,5 cm w 1627 r. Globusy Planciusa zostały opublikowane przez trzech wydawców z nowo wykonanych matryc: Matthaeusa Greutera w 1636/1638 r. (śr. 26,5 cm), Jeana Boisseau w 1644 r. (śr. 14,5 cm) i Romsteta w 1691 r. (śr. 26,5 cm). Obecnie wiadomo o czterech egzemplarzach globusów Romsteta: dwóch Ziemi i dwóch nieba. Bardzo podobny do omawianego obiekt znajduje się w Bibliotece Księżnej Anny Amalii w Weimarze.
Metalistería vaccea. I. Armamento
Authors: Sanz Mínguez Carlos , Carrascal Arranz Juan Manuel
Published: October 2024

La ausencia de recursos minerales en las tierras centrales de la cuenca del Duero no supone un impedimento para que los vacceos desarrollen una variada tipología de elementos tanto de hierro (armas, instrumentos utilitarios o productivos), como de bronce (objetos suntuarios). Entre las primeras destacan las espadas de tipo Miraveche, los puñales Monte Bernorio, los puñales de filos curvos, las lanzas y jabalinas, los cuchillos y los escudos.
Mujeres, esfera pública e interseccionalidad
Authors: Sáez Lara Carmen
Published: October 2024

La presente obra trata de abordar con detalle el problema de la crisis de representación de algunos colectivos de mujeres que, ya insertos en la reivindicación feminista, sin embargo, no están respaldados por un diálogo, desde la participación social y política, con las instituciones. A partir de la óptica jurídica y politológica y desde la interseccionalidad, como perspectiva de análisis, nos planteamos una cierta crisis del concepto de representatividad y del propio sistema político-participativo. Aquellas mujeres que más riesgo de exclusión sufren (mujeres racializadas, mujeres migrantes, mujeres discriminadas por razón de identidad de género y orientación sexual, mujeres del mundo rural, etc.) requieren que se visibilice esta parte del feminismo; pues, sus organizaciones son canales de participación privilegiada, de los que parten las reivindicaciones de sus dificultades concretas. Desde esta idea, se pretenden ofrecer a los poderes públicos unas bases que expongan las razones de esa desigualdad estructural; ya que la misma circunscribe de un déficit de representación de necesidades e intereses de determinadas mujeres, como las que se insertan en los colectivos y mencionados. Desde un enfoque multidisciplinar, presidido por el Derecho Constitucional y la Ciencia Política, a partir de la perspectiva de género y la interseccionalidad, en cuanto categorías analíticas; la pretensión de que se otorgue un cierto estatus a estas mujeres y posibilidades para luchar por un conjunto de derechos de cuyo ejercicio efectivo son excluidas. Al tiempo, expresar la necesidad de que comiencen a asumir responsabilidades y generar un diálogo para con las instituciones, de tal forma que sin arrebatarles las identidades que les son propias tengan un mayor sentimiento de pertenencia a la comunidad. La participación puede significarse como una herramienta de inclusión, desde la interseccionalidad.
Pharmaceutical Aids
Authors: VADAGA ANILKUMAR
Published: October 2024

Pharmaceutical aids, also known as excipients, are essential components in drug formulations that serve various functions beyond the active pharmaceutical ingredient (API). These substances play crucial roles in enhancing the stability, bioavailability, manufacturability, and patient acceptability of medicinal products. Common categories of pharmaceutical aids include diluents, binders, disintegrants, lubricants, glidants, and preservatives. Each type of excipient contributes uniquely to the overall performance of the dosage form. For instance, diluents provide bulk to small-dose drugs, while binders ensure tablet cohesion. Disintegrants facilitate the break-up of solid dosage forms in the gastrointestinal tract, enhancing drug release. The selection of appropriate pharmaceutical aids is a critical aspect of formulation development, requiring consideration of drug-excipient compatibility, stability, and regulatory compliance. Recent advancements in excipient technology have led to the development of multifunctional excipients and those derived from natural sources, addressing the growing demand for improved drug delivery systems and environmentally friendly options
Nasal and Ear Preparations
Authors: V Rakshana
Published: October 2024

Nasal and ear preparations are specialized dosage forms designed for local or systemic drug delivery through the nasal cavity and ear canal. This section explores the anatomy and physiology of the nasal and auditory systems, highlighting their unique features for drug administration. Various types of nasal formulations, including solutions, suspensions, and gels, are discussed along with their applications in local treatment and systemic drug delivery. The formulation considerations for nasal preparations, such as tonicity, pH, and viscosity, are examined to ensure efficacy and patient comfort. Ear preparations, including drops, ointments, and suspensions, are explored with emphasis on their specific requirements for safety and efficacy. The challenges in developing nasal and ear formulations, such as limited residence time and potential for irritation, are addressed along with strategies to overcome them. Advanced delivery systems, including nasal sprays and metered-dose inhalers for nasal administration, are discussed. Quality control measures specific to nasal and ear preparations, including sterility testing, particle size analysis, and spray pattern evaluation, are detailed
Tablets
Authors: Sowmyasree Golla Venkata
Published: October 2024

Tablets are the most widely used solid dosage form in pharmaceutical practice, offering advantages such as precise dosing, stability, and patient convenience. This section explores the various types of tablets, including immediate-release, modified-release, and orally disintegrating tablets, each designed to meet specific therapeutic needs. The composition of tablets, including active ingredients and excipients such as diluents, binders, disintegrants, and lubricants, is discussed in detail. Tablet manufacturing processes, from wet granulation and dry granulation to direct compression, are examined, highlighting the factors influencing the choice of method. Critical quality attributes of tablets, such as hardness, friability, disintegration time, and dissolution rate, are explored along with their testing methods. The principles of tablet press operation and the impact of compression forces on tablet properties are addressed. Coating processes, including film coating and sugar coating, are discussed in relation to their functional and aesthetic benefits. Common tablet defects, their causes, and remedies are outlined to aid in troubleshooting manufacturing issues
Quality Control and Quality Assurance
Authors: Voleti Vijaya Kumar
Published: October 2024

Quality Control (QC) and Quality Assurance (QA) are integral components of pharmaceutical manufacturing, ensuring the consistency, safety, and efficacy of drug products. This section explores the principles and practices of QC and QA in the pharmaceutical industry. The distinction between QC and QA is clarified, with QC focusing on product testing and QA encompassing broader quality management systems. Various aspects of quality control are examined, including raw material testing, in-process controls, and finished product analysis. Analytical techniques commonly used in pharmaceutical QC, such as chromatography, spectroscopy, and dissolution testing, are discussed. The concept of specifications and their development is explored, highlighting the importance of setting appropriate acceptance criteria. Quality assurance principles, including risk management, change control, and continuous improvement, are addressed. The role of documentation in quality systems, including standard operating procedures (SOPs) and batch records, is emphasized. Good Laboratory Practices (GLP) and their application in quality control laboratories are discussed. The importance of method validation and analytical instrument qualification in ensuring reliable test results is highlighted. Quality metrics and their use in monitoring and improving manufacturing processes are explored.
Capsules
Authors: Saha Gourab
Published: October 2024

Capsules are versatile solid dosage forms that offer unique advantages in drug delivery and patient acceptance. This section covers both hard and soft gelatin capsules, exploring their composition, manufacturing processes, and applications. The properties of gelatin and alternative shell materials, including vegetable-based and hydroxypropyl methylcellulose (HPMC) capsules, are discussed in relation to their impact on drug stability and release. Capsule filling processes for powders, granules, pellets, and liquids are examined, including manual, semi-automatic, and fully automatic filling methods. The formulation considerations for capsule contents, including powder flow properties and compatibility with shell materials, are addressed. Modified-release capsule technologies, such as multi-particulate systems and liquid-filled hard gelatin capsules, are explored for their role in controlled drug delivery. Quality control tests specific to capsules, including weight variation, disintegration, dissolution, and content uniformity, are outlined. Common capsule defects, their causes, and prevention strategies are discussed to ensure product quality. The advantages of capsules in terms of taste masking, ease of swallowing, and potential for combination products are highlighted.
Mixing
Authors: Shanmugasundaram Sangeetha
Published: October 2024

Mixing is a fundamental unit operation in pharmaceutical manufacturing, essential for achieving homogeneity in various formulations. This process involves the combination of two or more components to produce a uniform mixture, crucial for ensuring consistent drug content and performance. Different types of mixing are employed based on the physical state of materials, including solid-solid, solid-liquid, and liquid-liquid mixing. The selection of appropriate mixing equipment, such as ribbon blenders, planetary mixers, or high-shear mixers, depends on the nature of the materials and desired outcome. Factors affecting mixing efficiency include particle size distribution, density differences, and rheological properties of the components. The concept of mixing mechanisms, including convection, diffusion, and shear, is explored to understand the principles underlying effective mixing. Challenges in pharmaceutical mixing, such as segregation and over-mixing, are addressed, along with strategies to overcome them. Quality control measures, including blend uniformity testing and in-process controls, are discussed to ensure the consistency of the final product
Size Separation
Authors: Singh Gaurav Pratap
Published: October 2024

Size separation is a crucial process in pharmaceutical manufacturing that involves the classification of particles based on their size. This operation is essential for achieving uniform particle size distributions, which directly impact drug dissolution, bioavailability, and manufacturing efficiency. Various methods of size separation are employed, including sieving, elutriation, and sedimentation. Sieving, the most common technique, uses a series of mesh screens to separate particles of different sizes. The principles of sieve analysis and the importance of selecting appropriate sieve sizes are discussed. Factors affecting sieving efficiency, such as particle shape, moisture content, and sieving time, are examined. Air classification and cyclone separators are explored as alternatives for fine powder separation. The concept of particle size distribution and its measurement using various techniques, including laser diffraction and image analysis, is introduced. Size separation plays a critical role in quality control, ensuring batch-to-batch consistency and meeting regulatory requirements for particle size specifications
Neoantigen-Based Cancer Vaccines: Current Innovations, Challenges and Future Directions in Personalized Immunotherapy
Authors: Ahmed Saad , Mazhar Muhammad Shayaan , Shabbir Muhammad Fahad
Published: October 2024

The development of neoantigen-based cancer vaccines represents a breakthrough in personalized immunotherapy due to their ability to elicit strong and effective tumor-specific immune responses. Unlike conventional cancer vaccines, neoantigen vaccines target mutations found explicitly in tumor cells, thus maximizing specificity and minimizing immune tolerance. The review explores the current status of neoantigen vaccines and their mechanisms, development, and clinical applications. In contrast, it also explores the challenges of personalized vaccines, such as identifying neoantigens and their manufacturing, along with biological factors and regulatory hurdles. Future innovations and strategies are discussed to overcome resistance and relapse. Critical issues like global access, equity, and scalability must be addressed for its more comprehensive implementation. This review article discusses the potential of neoantigen vaccines in cancer therapy, detailing ongoing research and clinical trials, while addressing the persistent challenges that must not be underestimated.
PRINCIPAIS CAUSAS DA PERDA PRECOCE DOS IMPLANTES DENTÁRIOS OSSEOINTEGRADOS
Authors:   Graziano Medeiros C. de Sousa, Campos Erik Luan Jesus
Published: October 2024

Osseointegration, crucial for implant success, can be compromised by biological, mechanical, and systemic factors. The study aimed to investigate the main causes of early failure of osseointegrated dental implants, which, despite advances in implantology, still present a clinical challenge. The methodology consisted of a comprehensive literature review, using articles published between 2014 and 2024, from databases such as Scielo and Google Scholar. Relevant studies were selected using the descriptors “dental implant,” “subperiosteal implant,” and “osseointegration,” addressing causes such as peri-implantitis, insufficient bone quality, and technical failures during installation. The results indicate that early implant failure is associated with inflammatory complications, such as peri-implantitis and peri-implant mucositis, as well as factors like low bone density, inadequate immune response, and occlusal overload. Systemic conditions, such as diabetes and smoking, were also highlighted as significant risk factors for implant failure. Correct technical execution, combined with proper planning, proved to be essential in minimizing failures and ensuring long-term success.
AVALIAÇÃO DA TÉCNICA DE ARTRORRISE SUBTALAR NO TRATAMENTO DO PÉ PLANO VALGO FLEXÍVEL PEDIÁTRICO: UMA REVISÃO DE LITERATURA
Authors: Segundo Roberto Pacheco de Almeida , Falcão Rhayana Oliveira , Paixão Gustavo Henrique Cavalcanti Pereira , Pacheco Ádila Caroline Araújo de Almeida , Cruz Mário Augusto Ferreira
Published: October 2024

Introduction: Flexible flatfoot is characterized by loss of the medial longitudinal arch and subtalar eversion and is a prevalent orthopedic condition among pediatric patients. Subtalar arthroereisis has emerged as an effective surgical option for the correction of this deformity, without the need for fusion of the subtalar joint or osteotomies. The aim of this study is analyze the available evidence on the efficacy and safety of subtalar arthroereisis in the treatment of flexible pediatric flatfoot. Methodology: This is an extended literature review study through bibliographic research using the terms subtalar, arthroereisis, and flexible flatfoot. The inclusion criteria included original articles published in the last 10 years. Results: Seven articles were selected to compose the review database. The studies addressed skeletally immature patients and evaluated the results of subtalar arthroereisis. Based on our articles, the results demonstrate a significant reduction in pain and adequate correction of deformities, regardless of the type of implant used – be it absorbable or non-absorbable. The procedure has a relatively low complication profile, which reinforces its reliability as a viable alternative for pediatric patients. The most common complications, such as implant loosening, incomplete correction, tarsal bone pain and screw breakage, were observed in a minority of cases. Conclusion: Subtalar arthroereisis presents an effective and safe surgical option for the treatment of flexible flatfoot foot in children.
FRAMES EM JOGO NA CONSTRUÇÃO DO CONHECIMENTO
Authors: Pereira Fábio Araújo
Published: October 2024

A Semântica de Frames é uma teoria presente nos mais diversos campos de conhecimento, como a sociolinguística, psicologia e a linguística cognitiva. Baseia-se no conceito de que as palavras acionam imagens ou esquemas que, por sua vez, trazem à tona outros termos relacionados. Isso demonstra que os vocábulos pertencem a domínios específicos. Ao acionarmos o frame “restaurante”, por exemplo, toda uma cadeia de rituais e procedimentos relativos a esse domínio emergem. Assim, mesmo que se use outros termos como self service ou rodízio, a referência não deixará de ser captada. Um mesmo frame pode ser acionado por termos distintos, ou uma palavra pode ser capaz de fazer referência a frames diversos, uma vez que palavras podem ser emprestadas de um contexto para um outro metaforicamente para melhor ilustração de uma ideia. São inúmeros os exemplos de como os conteúdos dos vocábulos são moldáveis ao uso e apresentam vulnerabilidade nas situações. Goffman (1974) corrobora que frames são eventos que variam a depender do que é incluído na cena. Este é um dos pilares da teoria goffiniana a respeito da Semântica de Frames. Comunidades de fala possuem suas normas, hábitos e linguagens que traduzem seus valores, crenças e ideias, que tendem a permanecer por um longo tempo, mas podem sofrer mudanças. Também podem existir diferentes “mundos” em uma mesma esfera social, causando frequentes choques de realidade entre seus membros. Este trabalho tem, como suporte teórico, os estudos de Fillmore (1982), Lakoff (2006;2012) e Goffman (1974).e a análise realizada teve como objetivo examinar se os frames partem de constructos internos ou externos dos sujeitos falantes, considerando a recorrente dificuldade de definição de frames, diante de seu entendimento como conhecimento interno dos sujeitos ou como algo que emerge diretamente da interação social dos indivíduos. Por meio do estudo realizado, de natureza qualitativa e exploratória, constatamos que os resultados sugerem que é possível afirmar que tanto os constructos internos quanto os mais externos contribuem para uma melhor compreensão do que são Frames Semânticos.
REVISÃO SISTEMÁTICA: TRATAMENTO DE FRATURAS - COMPARAÇÃO ENTRE ABORDAGENS CIRÚRGICAS E CONSERVADORAS
Authors: Dias Bruno Alves
Published: October 2024

O tratamento de fraturas ósseas continua a ser um desafio significativo na ortopedia, envolvendo diversas abordagens cirúrgicas e conservadoras. Esta revisão sistemática examina os avanços mais recentes no manejo de fraturas, com ênfase em técnicas inovadoras e evidências clínicas publicadas nos últimos cinco anos. Foram incluídos estudos sobre fraturas de membros superiores, inferiores e coluna vertebral, bem como revisões sobre o uso de terapias biológicas, como o plasma rico em plaquetas (PRP), e tecnologias emergentes, como a impressão 3D no planejamento cirúrgico. A revisão abrange estudos comparativos entre tratamentos conservadores e intervenções cirúrgicas, incluindo fixação interna e externa, além de discutir os benefícios e complicações associados a cada abordagem. Os resultados indicam que o uso de tecnologias avançadas, como modelos 3D e PRP, têm mostrado benefícios em termos de precisão cirúrgica e aceleração da cicatrização óssea. Por outro lado, tratamentos conservadores continuam a ser eficazes em determinados casos. Um foco especial foi dado ao tratamento de fraturas em pacientes idosos, destacando os desafios únicos no manejo de fraturas osteoporóticas. Concluímos que a escolha da abordagem deve ser individualizada, considerando o tipo de fratura, o perfil do paciente e as tecnologias disponíveis.
A Study on Evaluating Determinants of Factors Influencing Environmental Social and Governance (ESG) Investments
Authors: Sohil Altaf Pirani  , Dr. Ravindra Patil
Published: October 2024

Investments that take social responsibility, environmental sustainability, and corporate governance into account are referred to as ESG investments. It supports businesses that put sustainability and moral behavior first to foster long-term success. Financial gains can be obtained through ESG investments while ensuring beneficial social benefits and risk management. The increasing recognition of ESG investments as an essential aspect of sustainable finance, that emphasise the significance of grasping the variables influencing investor choices in this field.  The purpose of the study was to evaluate determinants of Factors influencing ESG investments. The technique used in the current study is the Structural Equation Model. The findings of the study indicated that there is a significant impact of attitude, Environmental concern, perceived behavioral control, and subjective norms on behavioural intention towards ESG investments.
Harcama Gözden Geçirmeleri: Teorik Bir Perspektif
Authors: Bapbacı Özlem , Akdemir Tekin
Published: October 2024

Son iki yüz yıllık süreçte yaşanan küresel krizler, demografik değişiklikler, enerji talebi artışları, çevre sorunları, yaşlılık ve sağlık harcamalarındaki artışlar ile salgın ve pandemi gibi öngörülemeyen faktörler kamu harcamalarının artmasına yol açmıştır. Gelirdeki artışın harcama artışına eşlik etmemesi, 1980’lerden bu yana birçok OECD ülkesinde harcamaların etkinliğinin ve verimliliğinin ön plana çıkmasına sebep olmuştur. Bu durum, harcama gözden geçirmelerini gündeme getirmiştir. Bütçe harcamalarında etkinliğin arttırılması ve sosyoekonomik politika hedefleri doğrultusunda kaynakların önceliklendirilmesini sağlayan araçlardan biri olan harcama gözden geçirmeleri, mevcut harcamaları derinlemesine analiz ederek verimsiz harcamaların belirlenmesini ve bunların azaltılmasını, yeniden düzenlenmesini ya da iptal edilmesini sağlayan sistematik bir süreç olarak kullanılmıştır. Çalışmada, birçok OECD ve AB üyesi ülkede uygulama alanı bulan ve bütçe süreçleriyle entegre olarak çalışan harcama gözden geçirmelerinin teorik bir bakış açısıyla değerlendirilmesi yapılmıştır.
Aspectos clínicos, diagnóstico e manejo da Dengue: uma revisão atualizada
Authors: Dias Vanessa Moraes , Magalhães Bruna Garcia Vilar de , Anjos ⁠Natassiia Felsky Rodrigues dos , Fernandez ⁠João Henrique Martins , Anjos ⁠Gabriel Felsky Rodrigues dos , Paiva Ana Luiza Figueiredo , Medeiros Iasmim , Oliveira ⁠Alexandra Borges de , Oliveira Gabriella Borges de , Bett Gabriel Curvo , Ribeiro Jessika Zardini Dourado Cunha , Silva ⁠Thiago Matheus Ribeiro da
Published: October 2024

A dengue é uma doença viral transmitida por mosquitos do gênero Aedes, com ampla disseminação em regiões tropicais e subtropicais. Este estudo visa revisar os principais aspectos clínicos, diagnósticos e terapêuticos da dengue, com base nas evidências mais recentes. A metodologia utilizada foi a revisão bibliográfica de artigos científicos publicados nas bases de dados PubMed, Scielo e Google Scholar, entre 2014 e 2024, utilizando os descritores "dengue", "diagnóstico", "tratamento", "manejo clínico" e “Aedes aegypti”. Os resultados mostram que a dengue possui um amplo espectro clínico, variando de quadros febris leves até manifestações graves, como a dengue grave, caracterizada por extravasamento plasmático, hemorragias e disfunção orgânica. O diagnóstico é confirmado por métodos sorológicos e moleculares, sendo a detecção precoce crucial para o manejo adequado. O tratamento permanece de suporte, com ênfase em hidratação rigorosa e monitoramento clínico. Não há antivirais específicos, e o manejo das formas graves requer atenção hospitalar, devido ao risco de choque hipovolêmico. Conclui-se que o reconhecimento precoce da dengue e suas complicações é essencial para reduzir a mortalidade. Apesar dos avanços diagnósticos, a ausência de tratamento específico e a dificuldade no controle do vetor continuam sendo desafios significativos para a saúde pública. A revisão reforça a necessidade de medidas preventivas, como a vacinação e o controle ambiental dos mosquitos transmissores.
Comparative study of dynamic cyclic fatigue resistance of two files with different kinematics
Authors: ABDELSHAFY Rahma Mohamed , MAHRAN Abeer Hashem , FAHIM Mahmoud Mohamed
Published: October 2024

Objectives: The aim of the study was to determine the dynamic cyclic fatigue resistance (DCFR) of R-motion file and Protaper Next file (PTN) by differential scanning calorimetry (DSC) and scanning electron microscopy (SEM).
Methods: R-motion file (25/.06), PTN file (25/.06) were used and divided into 2 groups (n = 28) according to the file type. DCFR was performed using an artificial canal. Files were allowed to work until separation. The numbers of cycles to failure (NCF) and the time to fracture (TTF) were calculated. The files were subjected to DSC and SEM.
Results: R-motion files had higher NCF and TTF compared to PTN files. SEM examination showed that all files showed ductile fracture. DSC of the R-motion file displayed Austenitic phase at body temperature) 37 ˚C) while PTN file failed to demonstrate any peaks within the applied heat range. Conclusions: R-motion files had higher CFR and TTF than PTN files.
Conclusions: R-motion files had higher CFR and TTF than PTN files.
Investigation of fracture resistance with different diameters of polyetherketoneketone posts and cores material: A pilot study
Authors: KABBARA Maya , HAROUNY Ryan , RAHME Habib
Published: October 2024

Objectives: The primary objective of this study is to investigate the resistance to fracture of Polyetherketoneketones PEKK, used as post and core by fabrication in different diameters in the canal, and comparing the test results for each group.
Methods: Thirty extracted mandibular premolars were selected, endodontically treated and prepared to receive the post and cores milled from polyetherketoneketone disk. The specimens were randomly divided into five groups (n = 6) respectively: group 1 received pekk post with diameter = 0.70 mm, group 2 received pekk post with diameter = 0.90 mm, group 3 received pekk post with diameter = 1.10 mm, group 4 received pekk post with diameter = 1.50 mm, and group 5 received pekk post with diameter = 1.70 mm. All the posts were cemented using a self-adhesive resin cement. Fracture resistance was tested using a universal testing machine, failure patterns were then observed visually and radiographically. For the fracture resistance test, the Universal Testing machine employed the load cell of 10KN and the speed of the cross head of 1mm/min. Data was analyzed using Oneway analysis of variance (ANOVA) followed by Tukey post-hoc test in order to determine significant differences among groups and the materiality threshold was set at α = 0.05.
Results: Statistical analysis revealed that the observed differences among the five groups were not significant. None of the PEKK posts caused any fracture in the root, and this observation was visually and radiographically confirmed across all groups.
Conclusions: The dentist will be able to turn the diameter of the PEKK post and core as thin as 0.70mm till 1.70mm depending on the clinical requirement with no risk of root fracture, as specified by the guidelines of this research.
Assessment and quantification of the microbial flora in the output water of two types of dental chairs: A comparative study
Authors: KHARMA Khalil , HARDAN Louis , KASSIS Cynthia , BOURGI Rim , GEITANI Regina , MALLAH May , MAALOUF Elie , MEHANNA ZOGHEIB Carina
Published: October 2024

Objectives: Dental Unit Waterlines (DUWL) have shown to be a perfect host for different pathogenic microorganisms. The purpose of this study was to analyze and compare the level of bacterial contamination in the output water of 2 types of DUWL.
Methods: Dental unit water samples from the air/water syringe of the A-dec (A-dec™ Performer 200, Newberg, USA) DUWL type and KaVo (ESTETICA™ E30/E70/E80 Vision, Kavo, Biberach, Germany) type were collected and analyzed for total aerobic flora, Pseudomonas aeruginosa, faecal coliforms, total coliforms, faecal streptococci and sulfite-reducing anaerobic flora.
Results: The bacteriological analysis of water samples shows the presence of bacterial contamination at high levels exceeding the standard safety guidelines of 100 CFU/mL set up by the American Dental Association (ADA) and accepted by the Centers for Disease Control and prevention (CDC) on the heterotrophic bacterial load. The data shows no statistically significant differences for all bacteriological parameters studied between the conventional A-dec DUWL type and the KaVo type that has an automated mode of decontamination.
Conclusions: Despite all the disinfecting solutions considered to eradicate the bacterial proliferation in DUWL, the problem remains one of the greatest challenges in modern dentistry. Practitioners and medical staff should not underestimate the harmful consequences of this bacterial growth, not only on the health of their patients but also on their own health.
Comparative evaluation of surface changes and bond strength of microabrasion bleached enamel before and after remineralization with nano-hydroxyapatite paste: In vitro study
Authors: DUBE Ridhi , TANDALE Anita , KISHOR TALREJA Twinkle , KRISHNAKUMAR Karishma , KOKATE Prajakta , JEMINI KASAT Vaishnavi
Published: October 2024

Objectives: Comparative evaluation of surface changes and bond strength of Microabrasion Bleached enamel before and after Remineralization with Nano-hydroxyapatite paste, an In vitro study.
Methods: Enamel samples were divided into - Group I - Conventional bleaching (HB), Group II - Conventional bleaching with remineralization (HB+N-Hp), Group III - Microabrasion-assisted bleaching (M+HB), and Group IV - Microabrasion-assisted bleaching with remineralization (M+HB+N Hp). Surface roughness was measured using a profilometer. Samples were stored in artificial saliva for two weeks, then bonded with nanofilled composite resin and subjected to shear bond strength (SBS) analysis.
Results: Group IV (M+HB+N-Hp) showed higher surface roughness than Groups I (HB) and II (HB+N-Hp), while Group II had significantly lower surface roughness compared to Groups III (M+HB) and IV. In terms of shear bond strength (SBS), Group III exhibited significantly higher SBS than Group I, whereas Group II showed significantly reduced SBS compared to Group I. All values were statistically significant.
Conclusions: Remineralization with N-Hp reduces the surface roughness caused by bleaching and microabrasion, potentially decreasing bacterial biofilm adherence. Despite increased surface roughness correlating with better bond strength, microabrasion-assisted bleaching followed by remineralization and direct composite veneering after two weeks is a promising minimally invasive treatment for severe tooth discolorations. Further studies should explore varying frequencies and concentrations of N-Hp application.
Aesthetic rehabilitation of a complex crown-root fracture by fragment reattachment with a fiber-reinforced post: A case report
Authors: SAIDI Sarra , FEJJERI Meriem , TLILI Mahdi , JAAFOURA Sabra , FRIH Nadia
Published: October 2024

Complex crown-root fractures are characterized by the involvement of both crown and root with pulp exposure. They pose aesthetic, functional, and psychological problems for the patient. Furthermore, they can pose technical difficulties for the practitioner. The purpose of this case report is to describe the management of a complex crown-root fracture of the right upper central incisor with subgingival limit by reattaching the tooth fragment with fiber-reinforced post. We considered a coronal elongation (gingivectomy and osteoplasty) to recreate the biological space and to expose the limit of the fracture line to guarantee the quality of the bond.
Clinical management of mandibular permanent premolars with periapical lesion and bilateral supernumerary teeth: A 7-years follow-up case report
Authors: PIRANI Chiara , SABER Shehabeldin , IACONO Francesco
Published: October 2024

Objectifs: This 7-years follow-up case report describes two diversified strategies for the management of bilateral mandibular permanent premolars associated with periapical lesion and unerupted supernumerary teeth.
Case Report: A non-syndromic 9 years-old Asian female patient presented pain and swelling of the 35 in anatomical contiguity with an immature and unerupted supernumerary tooth. Clinical examination revealed an intraoral vestibular sinus tract related to the necrotic 35. Periapical radiography and CBCT showed that the 35 had an immature apex associated with a periapical lesion, and a supernumerary tooth in a lingual direction. Endodontic treatment of the 35 was performed by creating an apical plug with ProRoot MTA, while the supernumerary tooth was monitored radiographically with no intervention. Four years later, the 45 developed the same clinical condition of the left arch. Radiographic examination revealed a periapical lesion with massive periapical bone resorption, and a supernumerary tooth in normal alignment. The second premolar was herein extracted to allow for eruption of the supernumerary tooth.
Outcomes: 3-years follow-up revealed continued root maturation and its spontaneous eruption in the dental arch. Proper healing of both mandibular lesions was monitored after 10 months, 3-years and 7-years revealing no recurrence on both sides.
Endocrown : from preparation to bonding : Case report /// L'endocouronne : de la préparation au collage : à propos d'un cas clinique
Authors: YOUSFI Amira , DAKHLI Rihab , SAAFI Jilani , HARZALLAH Belhassen
Published: October 2024

The restoration of endodontically treated teeth is a real challenge, particularly teeth with extensively damaged coronal tissues. The use of post-retained restorations has been discussed because of the potential tooth weakening due to the additional removal of sound dental structures. In fact, long-term prognosis of a devitalized tooth is closely related to the coronal restoration’s quality and the remaining dental structure.With the development of adhesive dentistry and minimally invasive preparation, new approaches have emerged. Among them, the endocrown which is monolithic ceramic bonded restoration, anchored to the internal portion of pulp chamber and cavity margins that have been used as an alternative to conventional post and core.
Communication in Health Care Services: An Overview of the Legal Position of Informed Consent
Authors: Muhammad Hatta  , Cut Khairunnisa  , Sri Wahyuni
Published: October 2024

The principle of informed consent requires physicians to communicate with patients before administering medical treatment. The information provided by physicians serves as a guide or consideration for patients when making an informed decision and gives the physician permission to proceed with the medical intervention. The obligation of physicians to communicate effectively has been regulated in Articles 35 and 45 of Law No. 29 of 2004 concerning Medical Practice and further strengthened by the Regulation of the Minister of Health of the Republic of Indonesia No. 290/ Menkes/ Per/ III/ 2008 concerning Approval of Medical Measures. Effective communicationin health care services cannot be exaggerated when it comes to providing medical care. Before the administration of medical treatment, the patient had already been informed of his condition, the probability of recovery, the potential risks associated with treatment and alternative therapy methods to ensure that patients were well informed about the disease and procedures that would be performed by physicians. Efficient communication between patients and healthcare providers is crucial to preventing medical malpractice.
The Criminal Acts of Corruption as Extraordinary Crimes in Indonesia
Authors: Johari  , Teuku Yudi Afrizal
Published: October 2024

Corruption in Indonesia Law is almost present throughout the Law of the government, h at the central and regional levels. Although there are various disagreeing parties of corruption classified as extraordinary crimrally argue that corruption in Indonesia can be categorized as an e,xtraordinary crime because it is organized, systemic, a,nd has been looting so that it can negatively impact economic growth, legal enforcement, and national security stability. Therefore, to combat corruption crimes in Indonesia, the government has issued  No. 31 of 1999 and No. 20 of 2001 on the eradication of corruption crimes as a legal basis for the eradication of corruption in Indonesia. However, with the issuance of Law No. 19 of 2019 for the amendment of Law No. 30 of 2002 on the Eradication Commission, various legal experts have assessed that corruption crimes in Indonesia can no longer be classified as extraordinary crimes because some of the extraordinary powers that KPK has as the spearhead of corruption eradication in Indonesia have been eliminated
The Legal Position of Corporate Crime in Indonesia
Authors: Joelman Subaidi  , Budi Bahreisy
Published: October 2024

In the context of Indonesian criminal law, legal subjects extend beyond humans or individuals to include legal entities or corporations. Corporations, as legal entities that can be held accountable for their actions, are subject to a range of legal frameworks, including those outlined in various laws such as Law No. 7 Drt. Year 1955 concerning Investigation, Prosecution and Trial of Economic Crimes, Law No. 31 Year 1999 as amended by Law No. 20 Year 2001 concerning Amendments to Law No. 31 Year 1999 concerning Eradication of Crimes, Law No. 9 Year 2013 concerning Prevention and Eradication of Criminal Acts of Terrorism Financing, Law No. 31 Year 1999 concerning Corruption Eradication, Law No. 41 Year 1999 concerning Forestry and others. Criminalizing corporations differs from criminalizing individuals due to the inherently distinct nature of corporations, which is not subject to the same legal principles as individuals within the criminal law. While certain forms of punishment can be imposed upon people, they are not applicable to corporations; for example, imprisonment and death penalty. Therefore, it is necessary to impose an appropriate form of punishment on corporations in order to achieve the objectives of criminalization. Accordingly, a variety of sanctions exist that are regulated by several different laws, including probation sanctions, equity fines, diversion to alternative sanctions, supplemental sanctions, community service sanctions, the authority of external legal entities, and the requirement to purchase shares.
The Influence of Prenatal Yoga Exercise on Mother Anxiety Pregnant
Authors: Mamah Suhaeriah  , Linda K Telaumbanua  , Astrid F Sianipar  , Nurmah
Published: October 2024

Anxiety during pregnancy not only affects the health of pregnant women but can also have an impact on the delivery process such as premature labor, prolonged labour, cesarean delivery, low birth weight. Based on WHO data, there are around 10% of pregnant women with psychological disorders and about 13% of postpartum women worldwide. This incidence is higher in developing countries in pregnant women, namely 15.6% and 19.8% in postpartum women. The purpose of this study is The Effect of Prenatal Yoga Exercise on the Anxiety of Pregnant Women at TPMB Mamah Suhaeriah in 2022. Research method This type of research uses the Pre-Experimental method with a one group pretest-posttest design approach. Sampling using total sampling with a total sample of 20 respondents. The research instrument used was an observation sheet. The data analysis used is the Wilcoxon Sign Rank Test statistical test. Research results based on the results of statistical tests using the Wilcoxon Sign Rank test, the p-value (0.000
Review of the genus Pterolamia Breuning, 1942 (Coleoptera, Cerambycidae) with description of a new species from China
Authors: Xie Guang-Lin
Published: October 2024

In this study, the genus Pterolamia Breuning is briefly reviewed, and the second species, Pterolamia quadricristata sp. nov., from Hunan, China, is described and illustrated.