bluuebunny/crossref_metadata_2025 huggingface dataset:
Recent Patents on Phytoconstituents-based Formulations for the Treatment of Acne Infection: A Review
Authors: Singh Vandana , Verma Ravinder , Kaushik Deepak , Mittal Vineet
Published: September 2020

Background:

Acne is an infection of the skin that occurs in both men
and women during their lifespan. There are various natural or synthetic products
available in the market to prevent and cure this disease.

Introduction:

The majority of the world population depends on the herbs or natural
resources for the relief of acne disease. These are used to lessen the cost of
treatment and the side effects of synthetic analogs.

Methodology:

We have explored the various authentic web resources to compile information
regarding different patented and marketed herbal formulations for
acne treatment.

Results:

It has been found that most of the herbal formulation for acne include
the plant actives/extracts having the potential activity against the Propionibacterium
acne. The occurrence of this skin disease is also associated with the presence
of free radicals in the body, which also causes the inflammation and redness of
the skin. Further, the study of various patents also revealed that herbs with
anti-oxidant properties have been used in most of the herbal anti-acne formulations.
Moreover, the various patents also give the idea that herbal formulations also
prevent the appearance of pimples on the skin.

Conclusion:

It has been concluded that the herbal anti-acne formulation is not only
used to treat acne but also prevents this disease safely and economically.
Synthesis of 1H-1,2,3-Triazole-Linked Quinoline-Isatin Molecular Hybrids as Anti-Breast Cancer and Anti-Methicillin-Resistant Staphylococcus aureus (MRSA) Agents
Authors: Awolade Paul , Cele Nosipho , Ebenezer Oluwakemi , Kerru Nagaraju , Gummidi Lalitha , Gu Liang , Palma Gabriella , Kaur Mandeep , Singh Parvesh
Published: September 2020

Background:

The persistence of breast cancer as the leading cause of mortality among women, coupled
with drug resistance to tamoxifen, the standard endocrine therapy for the disease, exacts continuous attention.
To this effect, molecular hybridisation offers an attractive route to drugs with improved bioactivity profiles.

Objective:

The primary goal of this study was to examine the potential of 1H-1,2,3-triazole linked quinolineisatin
molecular hybrids as drug candidates against breast cancer and Methicillin-Resistant Staphylococcus
aureus (MRSA) cells.

Methods:

The quinoline-isatin hybrids were synthesised via click chemistry-mediated molecular hybridisation
strategy. Anti-breast cancer activity was determined in 3-(4,5-dimethylthiazol-z-yl)-2,5-diphenyltetrazolium
bromide (MTT) assay using Estrogen-Responsive (ER+) MCF-7 and MDA-MB-231 (Triple-Negative Breast
Cancer -TNBC) cells, while antimicrobial efficacy was established via the broth dilution method. Also, the
toxicity profile of potent compounds to non-cancerous cells was determined using human embryonic kidney
cells (HEK293) and human Red Blood Cells (hRBCs). In silico techniques were employed to predict the druglike
properties of potent compounds and understand their binding modes with Estrogen Receptor alpha (ERα).

Results:

Compounds 7g-i exhibited the strongest cytotoxicity to MCF-7 cells with IC50 values of 23.54, 23.66,
and 32.50μM, respectively. Interestingly, compound 7h also emerged as the best drug candidate against MDAMB-
231 and MRSA cells with IC50=71.40μM and MIC80=27.34μM, respectively. Structure-activity relationship
analysis revealed that quinoline-2-carbaldehyde and 5,7-disubstituted isatin moieties confer desirable potency.
These compounds showed no significant cytotoxic or haemolytic effects on HEK293 or hRBCs in vitro at their
active concentrations; hence, eliciting their selectivity for cancer cells. In silico studies also presented the drugability
of potent compounds and the likely structural features interacting with amino acid residues at the ligandbinding
domain of ERα.

Conclusion:

These results suggest that the identified 1H-1,2,3-triazole-linked quinoline-isatin hybrids are viable
chemotypes that can be adopted as templates for the development of new anti-breast cancer and anti-MRSA agents.
“Non-Classical” Indication for Provocative Testing of Growth Hormone: A Retrospective Cohort Study in Adult Patients Under Replacement Therapy
Authors: Mancini Antonio , Bruno Carmine , Vergani Edoardo , Brunetti Alessandro , Palmisano Gerardo , Pontecorvi Alfredo
Published: September 2020

Background:

Adult growth hormone deficiency (GHD) is considered a rare condition.
Current guidelines state that GH provocative test is indicated in patients affected by organic hypothalamic/
pituitary disease or with a history of head injury, irradiation, hemorrhage or hypothalamic
disease with multiple pituitary deficiencies. Nevertheless, the clinical picture related to GHD
may be subtle.

Objective:

We have retrospectively evaluated the indication to GHRH+arginine test in our monocentric
cohort of patients treated with hrGH in order to assess whether other conditions had been
considered as a rationale for provocative testing.

Methods:

Ninety-six patients (51 females and 45 males), aged 19-67 years were included. The
GHRH+arginine test had been performed in 29 patients with organic hypothalamic/pituitary disease
and in 4 patients for Childhood onset-GHD (CoGHD). In other patients, the diagnosis was suspected
for “non classical” reasons in the clinical picture suspected for GHD.

Results:

Classical indications included previously known primary empty sella (n=15), pituitary
surgery (n=14), pituitary cyst (n=1), non-secreting pituitary tumors (n=3) but more than half of the
patients (57.3%) had been studied for “non classical” indications: metabolic syndrome (n=25), asthenia
(n=13), heart failure (n=4), osteoporosis (n=6), unexplained hypoglycaemia (n=1) and infertility
(n=6). The latter represented a significant percentage in the male subgroup under 45 ys.
IGF-1 levels were lower than 50th percentile in 63% of patients. Finally, among non-classical reasons,
organic pituitary disease was discovered in 22 patients.

Conclusions:

Idiopathic GHD may be unrecognized due to its subtle manifestations and that an extended
use of dynamic GH tests may reveal such conditions. A potential field of investigation
could be to identify subsets of patients with clinical conditions caused or worsened by underlying
unrecognized GHD.
Methodological Challenges in Investigating Supracondylar Fractures of the Humerus From a Child’s Viewpoint: Evolution of Study Protocol
Authors: Lim Brittany Tara , Chhina Harpreet , Pike Ian , Brussoni Mariana , Cooper Anthony
Published: September 2020

Background

Outdoor play and risk-taking behaviors, including play at heights, are important to children’s physical, social, and cognitive development. These aspects of play are important to consider when informing prevention policies for serious injuries that commonly occur on play structures. Supracondylar fractures of the humerus (SCH) are the most common type of elbow fractures that result from falls on an outstretched hand among healthy children. Despite being one of the leading causes of admission to the hospital and surgical intervention, the details surrounding the cause of these injuries are often not recorded. Previous research has correlated decreased overall playground safety with higher rates of SCH fractures. Play structure height and the type of undersurface have been identified as potential risk factors for severe injuries, including SCH fractures, in part due to low compliance with safety standards. This paper explores the challenges we encountered designing the study and the resulting insights and methodological modifications we made.

Objective

The aim of this paper is to discuss the challenges related specifically to clinical research in pediatrics and strategies developed to conduct a study that prioritizes the engagement and perspective of children and their families.

Methods

To explore the link between the severity of SCH fractures and children’s behavioral, environmental, and mechanistic factors, we conducted a mixed-methods study.

Results

During phase 1 (the original methodology) from April 2017 to July 2018, there were 58 eligible study participants and 17 were recruited. For phase 2 (the revised methodology) between October 2018 and October 2019, there were 116 eligible participants and 47 were recruited.

Conclusions

The changes in methodology made following the first phase of data collection were effective in our ability to recruit participants. By identifying and addressing challenges pertaining to recruitment and resource limitations, we were able to collect data in a concise manner while not compromising the quality of the data and make for an easily adoptable methodology for other sites interested in participating in the study. We hope that future studies that plan to employ a similar methodology can gain insight through the methodological challenges we have encountered and the way we adapted the methodology to build a more pragmatic approach.

International Registered Report Identifier (IRRID)

DERR1-10.2196/21816
Damage Probability Assessment of Hospital Buildings in Yogyakarta, Indonesia as Essential Facility due to an Earthquake Scenario
Authors: Muntafi Yunalia , Nojima Nobuoto , Jamal Atika Ulfah
Published: September 2020

Indonesia is a country located in an earthquake-prone region, and is characterized by significantly increased peak ground acceleration value. The seismic hazard map of Indonesia stated in SNI 1726-2012 and the current statistics published by PUSGEN in 2017 emphasized on the significance of assessing building damage probabilities, especially for essential structures in Yogyakarta. However, immediate action is required to handle response and recovery operations during and after a disaster. The aim of this study, therefore, is to ascertain the vulnerability and damage probability of hospital buildings in Yogyakarta by employing the 2006 earthquake scenario, where reports showed the destruction of over 156,000 houses and other structures. Furthermore, a Hazard-US (HAZUS) method was used for structural analysis, while a ground motion prediction equation was adopted to produce the building response spectra, following the characteristics of the earthquake incidence. The vital step in this assessment involves building type classification and identification of seismic design levels. However, the damage tendency of buildings is determined using the peak building response, which ensures the generation of capacity curves. The most significant findings on building damage probability value were less than 15% in each damage state (slight, moderate, extensive, complete). In addition, the optimum value was achieved at the minimum level of damage (minor), while the least values were recorded at the highest damage level (complete).
Non-Linear Finite Element Analysis of Flexural Reinforced Concrete Beam using Embedded Reinforcement Modeling
Authors: Effendi Mahmud Kori
Published: September 2020

Reinforced concrete is one of the most widely used building materials in Indonesia due to its workability, easiness, and reasonable price. Meanwhile, it is very important to understand the response of these elements during the loading process to ensure the development of an effective structure and one of the most effective numerical methods for reinforced concrete elements is the Finite Element Analysis (FEA). This study was, therefore, conducted to investigate the flexural behavior of reinforced concrete beam using a nonlinear finite element analysis through the application of the MSC MARC/MENTAT software program. This involved the use of a solid element to represent concrete while the truss bar was applied for reinforcing steel after which multi-linear and bilinear models were considered for the two elements respectively while embedded reinforcement model was applied to model the rebar. Moreover, the beam model was also studied and compared with experimental data from previous literature. The result showed the load-deflection to have significantly increased due to an increment in the steel reinforcement yield strength. The same was also observed for the concrete compressive strength while a decrease was recorded in deflection due to the reduction in the compressive strength because the strain was reaching the crushing value. Furthermore, the concrete tension model was found to be the same with the experimental results with the tensile strength observed to have lost its strength after reaching the tensile stress while the contact behavior of the modeled reinforced concrete beam showed the existence of a slip at the support and loading points.
Application of TRMM in the Hydrological Analysis of Upper Bengawan Solo River Basin
Authors: Senjaya Theo , Yudianto Doddi , Yuebo Xie , Adidarma Wanny K.
Published: September 2020

Rainfall is a major water resource with a significant role in terms of growth, environment concerns, and sustainability. Several human activities demand adequate water supply for drinking, agriculture, domestic, and commercial consumption. The accuracy of any hydrologic study depends heavily on the availability of good-quality precipitation estimates. Most countries are unable to provide sufficient climatic data, including rainfall and observed discharge statistics. This scarcity is a huge obstacle in conducting thorough hydrologic studies over a certain period. For instance, Indonesia, as an archipelagic country, has long been faced with data availability problems. For this reason, Tropical Rainfall Measuring Mission (TRMM), which was developed by NASA, became an alternative solution to rainfall data limitations. However, to be applied in hydrologic investigations, TRMM data require proper estimation and adjustment. The aim of this study was to evaluate the quality of TRMM rainfall data and its application in determining design flood and water availability. Dividing the data into several groups based on its magnitude and multiplying each unit with a correction coefficient are parts of the modification process. Subsequently, objective functions, including false alarm ratio (FAR), probability of detection (POD), and root mean square error (RMSE) were also applied. Rainfall-runoff modeling and design storm analysis at Delingan dam were used to study the TRMM correction performance. Based on the analysis, corrected TRMM showed considerable findings compared to ground station data.  Model calibration and verification using corrected TRMM data provide satisfactory model parameters compared to ground station derivatives. The results also disclosed a closer fit of the corrected TRMM to catchment response translated from derived rainfall-runoff model parameters to ground station compared to control.  Furthermore, design storm calculated from corrected TRMM reflects an improvement compared to uncorrected TRMM data.
The Diversity and Abundance of Egg Parasitoids in Brown Planthopper, Nilaparvata lugens Stål. (Hemiptera: Delphacidae) at Different Rice Growth Phases in Saketi, Pandeglang, Banten
Authors: Abdilah Nurullah Asep , Susilo Hadi
Published: September 2020

An extensive study about egg parasitoid biodiversity in different plant growth stages is an important need. This study was aimed to determine the diversity and abundance of egg parasitoids Nilaparvata lugens on different rice growth stages in Saketi, Pandeglang, Banten. The parasitoids sample was collected three times with two days interval sampling in three villages, i.e. Sodong (location I), Sindanghayu (location II), and Sukalangu (location III) from February to September 2018. Ten plants (as bait: rice that infected by N. lugens eggs) were put during two days along the transect line (100 meters) with 10 m space in between. The findings revealed that the abundance richness (S), the diversity index (H'), and similarity (J') of egg parasitoids of N. lugens were higher in the location I than those in the locations II and III. The study indicated that the diversity and abundance of egg parasitoids of N. lugens decreased in the generative phase of rice growth.
In Vitro Cultivation of Aphelenchoides besseyi Christie on Fungal Cultures
Authors: Imamah Annisa Nur , Supramana Supramana , Damayanti Tri Asmira
Published: September 2020

White tip disease on rice caused by Aphelenchoides besseyi is categorized as emerging infectious disease in Indonesia because the disease incidence and its geographical distributionare increasing rapidly. Until presently, there is no information related with mass culture technique of Ap. besseyi in Indonesia. Thus, studies to obtain pure population of Ap. besseyi  are necessary to be conducted to support various research aspects in the future. This research is aimed to study Ap. besseyi pure mass culture technique by rearing the nematode on three fungal species. Three different fungal cultures on PDA medium, i.e. Alternaria padwickii, Fusarium semitectum, and Botrytis cinerea were tested as Ap. besseyi cultivation media. To obtain the optimum condition for nematode cultivation, the fungal cultures were incubated in three different temperature. The nematodes were surface sterilized with 0.1% streptomycin sulfate followed by washing with sterilized water before infesting the nematode into fungal culture. Subsequently, 25 sterilized nematodes were infested into 7 days old of fungal culture and incubated at 20ºC, 25ºC and 30 ºC. After 21 days, nematodes were harvested and counted the final population. Among fungal species tested as rearing medium, the best culture for Ap. besseyi reproduction was on Al. padwickii culture at 25 ºC with average final population up to 9,115 per petri dish and reproduction factor 364.6. At a 30ºC, Ap. besseyi was failed to develop its population in all the fungal cultures tested. It indicated that the optimum temperature for reproduction  of Ap. besseyi on those of  fungal  species was 20-25 ºC.
In Vitro Study of Action Mode of Rhodotorula minuta Dmg 16 BEP as Biocontrol Agents on Alternaria solani
Authors: Setiawan Wawan , Wiyono Suryo , Tondok Efi Toding , Kanti Atit , Sudiana I Made
Published: September 2020

Rhodotorula sp. is widely known as a biocontrol agent and is reported effective in controlling several diseases on crops. Rhodotorula minuta Dmg 16 BEP is an antagonist yeast from Indonesia which was effective in controlling various plant diseases. The objective of this research was to study the in vitro mode of action of R. minuta Dmg 16 BEP against Alternaria solani. The antibiosis ability of R. minuta Dmg 16 BEP to A. solani might be based on the activity of volatile compounds and not from its metabolites products. The growth of A. solani in paper disk assay and dual culture tests were not inhibited nor inhibitory zones  developed, whereas the inverse petridish test showed the growth inhibition of A. solani. The results of the chitinolytic activity test on chitin agar and proteolytic on skim milk agar showed that no clear zone was formed. R. minuta has a strong hyperparasitic ability according to the slide culture test as the yeast cells surrounded A. solani hyphae and caused damage to some parts of hyphae.
Stability of Resistance to Imidacloprid in the Brown Planthopper (Nilaparvata lugens Stål.) from Banyumas, Central Java
Authors: Diptaningsari Danarsi , Trisyono Y. Andi , Purwantoro Aziz , Wijonarko Arman
Published: September 2020

Imidacloprid is one of the insecticides that has been widely used to control the brown planthopper (Nilaparvata lugens Stål.). The excessive use of insecticides led to the development of insecticide resistance in N. lugens. This study was aimed to determine the stability of resistance to imidacloprid in N. lugens from Banyumas, Central Java Province. The five generations of selection increased the resistance ratio (RR) from 46.20-fold to 150.39-fold. To assess the stability of resistance to imidacloprid in N. lugens, the fifth generation was further reared for 10 generations without exposure to insecticides. The stability studies showed that resistance to imidacloprid was unstable with a decrease of resistance from 150.39-fold to 38.14-fold after 10 generations without selections. Continuous selections with imidacloprid for three generations could increase the resistance level from 150.39-fold to 216.13-fold. The unstable resistance could be managed by removing the selection pressure for a period of time or switching to insecticides with different mode of actions. Information regarding resistance stability would be useful to determine an effective resistance management strategies in N. lugens.
Property, Plant, and Equipment and IFRS Conversion from the U.S. Accounting Perspective—Technical Research Report
Authors: Kasztelnik Karina
Published: September 2020

This article analyzes matters related to IAS 16 Property, Plant, and Equipment from a random selected of the IFRS financial statements, with a particular emphasis on componentization and revaluation assets. There are two fundamental differences between IFRS and U.S. GAAP. The first difference is component depreciation required under IFRS. The second part is the option to revalue fixed assets to estimated market value under IFRS. The research has helped U.S. executives understand the complexities of global accounting for PP&E between U.S. GAAP and IFRS and then to know how these differences may potentially impact their multinational organization’s accounting function.
Selecting Efficient and Reliable Preservation Strategies
Authors: Altman Micah , Landau Richard
Published: September 2020

This article addresses the problem of formulating efficient and reliable operational preservation policies that ensure bit-level information integrity over long periods, and in the presence of a diverse range of real-world technical, legal, organizational, and economic threats. We develop a systematic, quantitative prediction framework that combines formal modeling, discrete-event-based simulation, hierarchical modeling, and then use empirically calibrated sensitivity analysis to identify effective strategies.

Specifically, the framework formally defines an objective function for preservation that maps a set of preservation policies and a risk profile to a set of preservation costs, and an expected collection loss distribution. In this framework, a curatorâ€™s objective is to select optimal policies that minimize expected loss subject to budget constraints. To estimate preservation loss under different policy conditions optimal policies, we develop a statistical hierarchical risk model that includes four sources of risk: the storage hardware; the physical environment; the curating institution; and the global environment. We then employ a general discrete event-based simulation framework to evaluate the expected loss and the cost of employing varying preservation strategies under specific parameterization of risks.

The framework offers flexibility for the modeling of a wide range of preservation policies and threats. Since this framework is open source and easily deployed in a cloud computing environment, it can be used to produce analysis based on independent estimates of scenario-specific costs, reliability, and risks.

We present results summarizing hundreds of thousands of simulations using this framework. This exploratory analysis points to a number of robust and broadly applicable preservation strategies, provides novel insights into specific preservation tactics, and provides evidence that challenges received wisdom.
Enfermedades respiratorias y gastrointestinales en pediatría: ¿cómo las manejan los padres en casa?
Authors: Henao Vega Daniela , Rivera Largacha Silvia , Suescún Vargas José M.
Published: September 2020

Objetivo: identificar cómo los cuidadores de pacientes pediátricos manejan los síntomas respiratorios y gastrointestinales y analizar diferentes aspectos como su arraigo y seguridad; también el posible impacto de dichas prácticas en la comunicación entre cuidadores y pediatras. Métodos: se realizó un estudio cualitativo, narrativo, desarrollado en el Instituto Roosevelt en Bogotá, Colombia, a través de doce entrevistas a cuidadores de pacientes pediátricos hospitalizados que cursaban con sintomatología respiratoria o gastrointestinal de forma aguda. Se indagó sobre el manejo inicial a dichos síntomas y su experiencia al compartir dichas prácticas con el médico tratante. Resultados:el grupo entrevistado incluyó cuidadores entre los veinte y los 42 años, con diferentes niveles de escolaridad; se encontró una variabilidad en el tipo de tratamientos para atender los síntomas respiratorios y gastrointestinales. Dentro de esta variabilidad se identificaron prácticas benéficas, inocuas o riesgosas para el manejo de los síntomas señalados. Respecto a la comunicación, la mayoría de los cuidadores sienten que el médico no brinda un espacio para hablar del tema y en caso de hacerlo hubo un rechazo. Conclusiones: se hallaron, por parte de los cuidadores, prácticas que coinciden con la postura médica, pero otras prácticas tenían alto riesgo para los menores y se deben corregir. Es necesario integrar y validar la narrativa del cuidador para disminuir prácticas peligrosas que pongan en riesgo la salud de los menores.
Elección de especialidad y actitud de médicos internos de pregrado hacia la Medicina Familiar
Authors: Joanico Morales Baltazar , Duran Patiño Ángel Giovani , Salgado Jiménez María de los Ángeles , Juanico Morales Guillermina , Leyva Leyva Gustavo
Published: September 2020

Objetivo: analizar la elección de especialidad y actitud de los médicos internos de pregrado (mip) hacia la Medicina Familiar (mf) después de cursar un nuevo modelo educativo con enfoque en el primer nivel de atención. Métodos: estudio transversal analítico realizado de diciembre de 2018 a febrero de 2019; participaron 141 mip del Hospital General Regional No.1 Vicente Guerrero del Instituto Mexicano de Seguro Social. Posterior a un año de que se implementara una nueva modalidad de internado médico enfocado al primer nivel, en el que se incrementó el tiempo de rotación por Medicina Familiar de dos a cuatro meses, se aplicó el Cuestionario de Actitud hacia la Medicina Familiar (camf) que explora la actitud hacia la mf, opinión de la rotación y su elección como especialidad y factores asociados. Se realizó análisis univariado y multivariado. Resultados: 98.6% presentó buena actitud hacia la mf (n=139), 34.5% la eligió como posible opción de especialidad (n=38), solo 3.5% la eligió como primera opción (n=5); la causa principal para elegirla es que brinda atención integral (22.6%, n=32) y para no elegirla es porque no les gusta (18.4%, n=26). La nueva rotación fue percibida como buena por 48 % (n=54); mediante análisis de regresión logística se encontró que al alumno que le gustó la rotación o prácticas por consulta de Medicina Familiar tiene 6.7 veces la probabilidad de seleccionar Medicina Familiar como opción de especialidad (ic 95%: 1.45-31.2). Conclusiones: a un año de la implementación del nuevo modelo con enfoque al primer nivel, la mayoría de los mip tienen buena actitud hacia la mf, sin embargo, no representa su primera elección como especialidad; las cualidades de la especialidad son los principales motivos para elegirla, el tiempo de internado no influyó su elección.
Therapeutic Modalities for Sars-Cov-2 (Covid-19): Current Status and Role of Protease Inhibitors to Block Viral Entry Into Host Cells
Authors: Qamar Sarmad Ahmad , Basharat Kanta , Bilal Muhammad , Iqbal Hafiz M.N.
Published: September 2020

An acute respiratory disease (SARS-CoV-2, also recognized as COVID-19/2019-nCoV), caused by nCoV created a worldwide emergency. The World Health Organization declared the SARS-CoV-2 as epidemic of international concern on January 2020. After SARS-CoV in 2002 and MERS-CoV in 2012, the emergence of SARS-CoV-2 is marked as third highly pathogenic coronavirus of 21st century. Till now, various researches have been conducted, highlighting SARS-CoV-2 as β-coronavirus with high phylogenetic and genomic similarity with bat-CoV, indicating bats as natural reservoir of coronaviruses. It has also been confirmed that SARS-CoV-2 uses the same (ACE2) receptor for host cellular entry as of SARS-CoV, and primarily spread through respiratory pathway. Evidences shows continuous human-to-human viral transfer, with numerous worldwide exported cases. Currently, there is no specific approved drug available for the treatment of SARS-CoV-2, but various anti-parasitic and anti-viral drugs are being investigated. In this review, we have described several possible therapeutic modalities for SARS-CoV-2 infection based on (i) host protease inhibitors to block viral entry into the cell; (ii) gene silencing using siRNA-based RNAi and (iii) type I interferons (IFN1)-based therapeutics have been discussed in detail. Background knowledge on these strategies highlight them as potential therapeutic targets, which could be evaluated on urgent basis to combat COVID-19 epidemic.
A Retrospective Analysis of Influence of Environmental/Air Temperature and Relative Humidity on Sars-CoV-2 Outbreak
Authors: Rahman Md. Arifur , Hossain Md. Golzar , Singha Atul Chandra , Islam Md. Sayeedul , Islam Md Ariful
Published: September 2020

Coronaviruses are a family of viruses causing mild to severe upper respiratory tract syndrome. Recent pandemic threat caused by SARS-CoV-2 first appeared in Wuhan, China in December 2019. Whether the COVID-19 might be affected by warming global temperatures like some of previous pandemic flues. Therefore, the current study aims to analyze the effect of temperature and relative humidity (RH) on the spreading of the SARS-CoV-2 infection. The confirmed cases of COVID-19 in 31 different provinces in China and 274 provinces and/or countries were obtained from an online database. The real time temperature and humidity of the respective regions were taken from another online weather reporting data source. Spearman [R(s)] rank correlation was performed to identify the relationship between the variables (e.g., temperature, number of confirmed cases etc.). The overall spreading of SARS-CoV-2 in relations to temperature was inversely correlated. Among 29 of 31 provinces of China the overall correlation coeffient of the relationship between temperature and viral spread was negative [-R(s)] where in 15 provinces the correlation was at significant level (p<0.05). Furthermore, there was a significant negative relationship observed between the SARS-CoV-2 spreading and air temperature throughout the 274 provinces and/or countries of the world. However, there was no significant co-relationship between humidity and COVID-19 spreading either in China or among countries and/or various regions of the world. The SARS-CoV-2 infection seems to be spread in a wide range of temperature throughout the world. Thus, several factors including temperature, may influnce the SARS-CoV-2 spreading. As a results, relatively elevated air temperature could not completely prevent viral spread but it might be one of the important detrimental factors for SARS-CoV-2 rapid spread.
Isolation of Bile Salt Hydrolase and Uricase Producing Lactobacillus brevis SF121 from Pak Sian Dong (Fermented Spider Plant) for using as Probiotics
Authors: Yasiri Atipat , Seubsasana Supawadee
Published: September 2020

The interesting application of bile salt hydrolase enzyme is reduction of cholesterol in serum and amelioration lipid profile. While uricase enzyme can be applied to convert insoluble uric acid to be soluble form and excrete from the body. Probiotics are living organisms with generally know that they can provide beneficial effects to their host. Several reports show that probiotic bacteria with bile salt hydrolase and uricase can improve hypercholesterolemia and hyperuricemia patient. The novel isolate of Lactobacillus from Pak Sian Dong in this study is identified as L. brevis SF121 and probably use as probiotic bacteria in the future. However, this isolate still need further experiments to investigate and improve properties of probiotics. Moreover, this finding suggests that Pak Sian Dong or fermented spider plant can be designated as a good source for probiotic screening and also defines as health-promoting diet.
Antibiotic Resistant Bacterial Pathogens Associated with Blood Stream Infections and Urinary Tract Infections among Intensive Care Unit Patients
Authors: Gunasekaran Shriram Dorairaj , Menezes Godfred Antony , Nazeem Rezmitha Zulfihar , Sultan Mohammad Obada , Archarya Tejaswini , Khadim Shaista , Sudha Resshme Kannan , Janardhan Harshita , Bhatia Mrinali Sanjay , Fathima Farzeen , AlKhateri Khulood , Magaogao Michael , Ali Sara Babiker , Hassan Hanadi Elias , Mahran Aly Essam El-Din , Al Saadi Azan Saleh
Published: September 2020

Blood Stream Infection (BSI) and Urinary Tract Infection (UTI) being leading causes of morbidity and mortality represent a common complication among critically ill patients. During the last decade, clinicians have observed a rising occurrence of BSIs due to bacterial resistance. Likewise, catheter-associated UTI is a main cause of morbidity and mortality affecting all age groups. Coliforms happen to be the prominent pathogens among our ICU admitted patients. It was alarming to notice 42.9% resistance to tigecycline among K. pneumoniae isolated from blood. K. pneumoniae isolates cultured from urine of ICU patients uniformly displayed 75% resistance to ciprofloxacin, ceftriaxone, cefoxitin and cefepime. Interestingly, it is of respite to observe 85.7% K. pneumoniae isolated from blood and 75% K. pneumoniae isolated from urine being susceptible to a conventional antibiotic, gentamicin. Escherichia coli isolated from urine were 100% susceptible to carbapenems and 91.75% were susceptible to tigecycline. Overall, 90% of Pseudomonas aeruginosa were susceptible to nitrofurantoin. The rapid spread of these MDR pathogens demands for national and regional guidelines. Policies to treat ICU related infections in UAE should be designed based on local microbiological data and resistance profiles of pathogens.
Pengaruh Konflik Pekerjaan-Keluarga dan Komitmen Organisasional terhadap Turnover Intention pada Hotel Bambu Indah Gianyar
Authors: Widiantara I Wayan , Martadiani Anak Agung Media
Published: September 2020

Turnover Intention adalah niat yang berasal dari dalam dirisendiri untuk berpindah dari pekerjaan yang lama dan mencari tempat kerja yang dirasakan lebih baik dari tempat kerja yang lama. Pokok permasalahan dalam penelitian ini adalah terdapat masalah mengenai turnover intention pada karyawan yang bertolak belakang dengan ketiga indikator dari turnover intention, seperti masih terdapat karyawan yang berpikir untuk pergi dari perusahaan, karyawan masih berkeinginan untuk mencari lowongan pekerjaan lain, dan karyawan yang berpikiran untuk keluar dari organisasi beberapa bulan mendatang. Jumlah sampel penelitian sebesar 80 responden. Metode yang digunakan proposional random sampling. Hasil dari penelitian ini menyimpulkan bahwasannya konflik pekerjaan-keluarga dan komitmen organisasional melalui uji secara parsial mempunyai pengaruh signifikan terhadap turnover intention pada Hotel Bambu Indah Gianyar. Sementara itu hasil uji simultan didapatkan bahwa konflik pekerjaan-keluarga dan komitmen organisasional secara bersama-sama mempunyai pengaruh signifikan terhadap turnover intention pada Hotel Bambu Indah Gianyar. Variable yang paling dominan pengaruhnya adalah konflik pekerjaan-keluarga. Turnover akan meningkat bila dipengaruhi oleh kedua variabel tersebut.
Pengaruh Kinerja Keuangan terhadap Nilai Perusahaan dengan Pengungkapan Corporate Social Responsibility Sebagai Variabel Pemoderasi
Authors: Prena Gine Das , Muliyawan I Gede Iwan
Published: September 2020

Penelitian dilakukan untuk menguji pengaruh kinerja keuangan yang diproksikan dengan ROA terhadap nilai perusahaan yang diproksikan dengan Tobin's Q dan menguji apakah Corporate Social Responsibility (CSR) mampu memoderasi hubungan antara kinerja keuangan dan nilai perusahaan. Pengumpulan data penelitian ini berasal dari publikasi yang diterbitkan di Bursa Efek Indonesia (BEI). Populasi dalam penelitian ini adalah perusahaan Manufaktur yang terdaftar di Bursa Efek Indonesia tahun 2017. Sampel dalam penelitian ini adalah perusahaan Manufaktur sesuai kriteria yang ditetapkan. Teknik analisis data yang digunakan dalam penelitian ini adalah regresi linier sederhana dan regresi moderasi untuk mengetahui variabel dependen yang dipengaruhi oleh variabel independen dan pengujian hipotesis menggunakan statistik-t untuk menguji koefisien regresi parsial. Selain itu juga dilakukan uji asumsi klasik yang meliputi uji normalitas, uji heteroskedastisitas dan uji multikolinieritas. Selama periode observasi, data penelitian berdistribusi normal. Berdasarkan uji normalitas, uji heteroskedastisitas dan uji multikolinieritas tidak ditemukan variabel yang menyimpang dari uji asumsi klasik. Hal ini menunjukkan data yang tersedia telah memenuhi persyaratan dengan menggunakan model persamaan regresi sederhana dan regresi moderasi. Hasil penelitian ini menunjukkan bahwa kinerja keuangan berpengaruh positif dan signifikan terhadap nilai perusahaan, artinya tinggi rendahnya rasio laba bersih terhadap total aset berimplikasi pada tinggi rendahnya nilai perusahaan. Begitu pula CSR yang mampu memoderasi kinerja keuangan terhadap nilai perusahaan, artinya pengungkapan CSR dapat memperkuat hubungan kinerja keuangan yang berimplikasi pada peningkatan nilai perusahaan.
Pengaruh Faktor Promosi, Pelayanan, Produk, dan Suku Bunga Terhadap Minat Menabung Mahasiswa Pada Bank Umum ( Studi Kasus BNI 46)
Authors: Gunawan Kadek Adi Putra , Purnami A. A. Sri , Senimantara Nyoman
Published: September 2020

Tujuan penelitian ini adalah untuk mengetahui pengaruh faktor Promosi, Pelayanan, Produk, dan Suku Bunga terhadap minat menabung mahasiswa pada bank umum. Teknik analisis data yang digunakan adalah uji regresi linier berganda, uji asumsi klasik, uji determinasi (R2), uji t dan uji F. Hasil penelitian ini Menunjukan Y= 2,547+ 0,152 X1+ 0,088 X2+ 0,460 X3+ 0,345 X4+ e. Hasil uji t menunjukan bahwa secara parsial variabel Promosi, Pelayanan, Produk, dan Suku Bunga berpengarung positif dan signifikan terhadap minat menabung mahasiswa pada bank umum. Dari hasil uji F menunjukan bahwa variabel Promosi, Pelayanan, Produk, dan Suku Bunga secara simultan berpengaruh signifikan terhadap minat menabung mahasiswa pada bank umum.
Pengaruh DPK, NPL dan Inflasi Terhadap Penyaluran Kredit Pada PT. Bank Mandiri Periode Tahun 2014 – 2018
Authors: Pinto Neria Graca Do Carmo Gomes , Bagiada Kompyang , Parameswara Anak Agung Gde
Published: September 2020

Kegiatan penyaluran kredit oleh bank mengandung risiko yang dapat berpengaruh pada kesehatan dan kelangsungan usaha bank, maka bank perlu memberikan penilaian terhadap nasabah yang mengajukan kredit serta merasa yakin bahwa nasabahnya mampu mengembalikan kredit yang diterimanya. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh DPK, NPL dan inflasi secara simultan dan secara parsial terhadap penyaluran kredit pada Bank Mandiri dari Tahun 2014 sampai Tahun 2018. Jenis data yang digunakan dalam penelitian ini adalah data kuantitatif. Teknik analisis yang digunakan analisis regresi linear berganda. Hasil yang diperoleh menunjukkan bahwa DPK, NPL dan inflasi berpengaruh positif dan signifikan terhadap penyaluran kredit bank pada PT. Bank Mandiri Periode 2014-2018 (sig < 0,05). DPK berpengaruh positif dan signifikan terhadap penyaluran kredit bank pada PT. Bank Mandiri Periode 2014-2018 (sig < 0,05). NPL berpengaruh positif dan signifikan terhadap penyaluran kredit bank pada PT. Bank Mandiri Periode 2014-2018 (sig < 0,05). Inflasi berpengaruh positif dan signifikan terhadap penyaluran kredit bank pada PT. Bank Mandiri Periode 2014-2018 (sig < 0,05) .
GENEALOGIA DA TEORIA DA IMPUTAÇÃO OBJETIVA
GENEALOGY OF OBJECTIVE IMPUTATION THEORY
Authors: Oliveira Leonardo Marcel de , Colen Guilherme Coelho
Published: September 2020

Este artigo tem como objetivo realizar uma abordagem das origens da moderna teoria imputação objetiva, que tem em Claus Roxin, desde 1960, o principal ensejo de seu desenvolvimento, inquirindo historicamente seus antecedentes doutrinários para investigar, sob prisma dogmático, o pano de fundo da sua construção contemporânea e quais as conseqüências sistemáticas da adoção de dita teoria na estrutura de imputação do tipo objetivo.
POST SCRIPTUM AO ARTIGO “HISTÓRICO, CARACTERIZAÇÃO E DINÂMICA RECENTE DO PRONAF - PROGRAMA NACIONAL DE FORTALECIMENTO DA AGRICULTURA FAMILIAR”
Authors: Schneider Sergio , Cazella Ademir Antonio , Mattei Lauro Francisco
Published: September 2020

Neste post scriptum, buscamos fazer uma atualização sobre a trajetória do Programa Nacional de Fortalecimento da Agricultura Familiar (Pronaf) desde que publicamos, em 2004, o capítulo de livro que está reeditado neste dossiê. Não tivemos o propósito de fazer uma extensa revisão dos debates e análises realizadas pela plêiade de estudiosos que trataram do tema, apenas apresentamos nossas impressões e pontos de vista sobre os alcances e os limites do Programa. Tentamos apresentar uma crítica construtiva, especialmente no que concerne a aspectos relacionados ao escopo e a gestão do programa, tais como o viés sulista da agricultura familiar, a concentração de recursos em alguns estratos específicos e as restrições de elegibilidade as unidades produtivas que possuem ingressos de fontes não-agrícolas. Argumentamos que estes aspectos merecem ajustes e que o Pronaf necessita se tornar mais inclusivo do ponto de vista social e melhor alinhado com os pressupostos do desenvolvimento rural sustentável.
EDITORIAL
Authors: Fossá Juliano Luiz , Aquino Joacir Rufino de , Matte Alessandra
Published: September 2020

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Determination of the copper-nickel ores formation sequence of the Kun-Manye deposit (Amur region)
Authors: Kotelnikov Alexander E. , Kolmakova Daria A. , Kotelnikova Elena M.
Published: September 2020

The purpose of the article is to determine the sequence of mineral formation of copper-nickel ores of Kun-Manie deposit, which is located in Zeya district of Amur region. Three ore chutes take part in the structure of the deposit. Ore-bearing formations are sheet and sheetlike bodies of ultra-basic composition of the Kun-Manien complex, lying among rocks of crystal foundation of the Early Archean. Among the rocks, hornblende differences of gabbro-pyroxenites and pyroxenites predominate. In addition to nickel, the ores contain a wide range of associated components. The ores oxidation zone within the deposit and the entire ore field is not developed. The relevance of the work is due to the fact that detailed studies of ore minerals have not previously been carried out. The study presented in the work was conducted by polarizing ore microscope on polished ore samples characterizing different zones of the ore body. The result of the study was the establishment of mineral paragenesis and the sequence of mineral formation. It has been determined that the main ore minerals are pyrrhotine, pentlandite, also found - pyrite, chalcopyrite, less often - ilmenite, magnetite, sphalerite, platinum group elements. Ore mineralization formed in two stages. The magmatic stage is an early and main mineral formation phases including pyrite-magnetite, polymetallic and pentlandite associations. The hydrothermal stage is a late phase involving a pyrite association.
Russia and Turkey: new trends and prospects at the present stage
Authors: Budarina Natalia A. , Ibragimov Ilias R.
Published: September 2020

The research of the scientific article is devoted to the current state of bilateral relations between Russia and Turkey, the main directions of cooperation and prospects of interaction. At the moment, in addition to comprehensive and deep relations between the two countries, Russia and Turkey are linked by trade, energy, investment and military cooperation. A survey conducted in Turkey showed that more than 70% of citizens have a positive view of the political and economic union with Russia. Turkey has become Russias fifth largest trading partner over the past two years, helped by the signing of a joint declaration on the lifting of trade restrictions and the normalization of economic relations. The article analyzes the volume of trade turnover with Turkey, considers promising investment projects, the role of mutual investments, and introduces formulas for calculating the indicators of complementarity and payback periods of the Akkuyu investment nuclear project.
Global artificial intelligence systems and technology market: formation and development trends
Authors: Matyushok Vladimir M. , Krasavina Vera A. , Matyushok Sergey V.
Published: September 2020

Every day more and more companies rely on artificial intelligence, from small startups to large companies, among which stand out not only the IT giants Google, Microsoft, Facebook, IBM, but even those that seemingly far from this topic - for example, General Motors and Boeing created a joint laboratory for AI research. It becomes obvious that AI technology is the real mainstream of our time. The article examines the global market for artificial intelligence systems and technologies. The authors described the peculiarities of the formation of this market and the main trends and segments in its development. The goal of research - identify the dynamics, features and trends of the global market for artificial intelligence systems and technologies. The methodology of system analysis, the dialectical method of scientific cognition, methods of historical, logical and comparative analysis are used. The concept of artificial intelligence has been systematized, the dynamics of the global market for artificial intelligence systems and technologies have been revealed, as well as in the regional context. The relationship between its dynamics and the sharp jump in performance of information processing algorithms, which became possible due to the fast computer based on GPUs, an avalanche-like data growth and the emergence of almost unlimited possibilities for storage and technology access, has been detected. It is shown that the global market for artificial intelligence technologies is in a phase of inflated expectations and with a high enough level of risk for investors. The main trends and segments in the development of the global market for artificial intelligence systems and technologies have been identified. These include deep learning technologies, the convergence of AI technologies with other technologies such as analytics, ERP, the Internet of Things, blockchain, and even quantum computing, which has the greatest impact, the development of cognitive intelligence systems, and the creation of a cognitive computer. It is shown that business leaders consider AI fundamental and absolutely necessary for the development of future business opportunities. It has been proven that the rapid development of AI systems and technologies is not just another technological innovation, but the technological platform of the Fourth Industrial Revolution, which is associated with hopes for accelerating the economic growth of the world economy, increasing the competitiveness of countries and companies.
China’s AI experience: industrial digitalization
Authors: Reshetnikova Marina S.
Published: September 2020

The rapid acceleration of scientific and technological progress, which started at the beginning of the 21st century, has become a decisive factor in influencing the global economy. Who will lead the global innovation race? This problem is especially relevant in the field of artificial intelligence (AI). At the moment, the United States and China are the main participants in the battle for dominance in this area. The author assesses Chinas innovative potential in the field of AI and identifies its achievements in this area. Based on the statistics provided, Chinas AI leadership has reached a critical point. China is confidently leading the new fundamental research of artificial intelligence, forming its theoretical base and applied research and development, which will contribute to the creation of new high-tech innovative products and services. However, in terms of the number and quality of AI specialists (AI Talents) and the number of companies engaged in AI, China is still lagging behind its main rival, namely the United States. The author proved that, despite the obvious successes of China, the United States still has an equal lead in the global innovation race.