bluuebunny/crossref_metadata_2025 huggingface dataset:
Quantification of forest carbon flux and stock uncertainties under climate change and their use in regionally explicit decision making: Case study in Finland
Authors: Junttila Virpi , Minunno Francesco , Peltoniemi Mikko , Forsius Martin , Akujärvi Anu , Ojanen Paavo , Mäkelä Annikki
Published: August 2023

Uncertainties are essential, yet often neglected, information for evaluating the reliability in forest carbon balance projections used in national and regional policy planning. We analysed uncertainties in the forest net biome exchange (NBE) and carbon stocks under multiple management and climate scenarios with a process-based ecosystem model. Sampled forest initial state values, model parameters, harvest levels and global climate models (GCMs) served as inputs in Monte Carlo simulations, which covered forests of the 18 regions of mainland Finland over the period 2015–2050. Under individual scenarios, the results revealed time- and region-dependent variability in the magnitude of uncertainty and mean values of the NBE projections. The main sources of uncertainty varied with time, by region and by the amount of harvested wood. Combinations of uncertainties in the representative concentration pathways scenarios, GCMs, forest initial values and model parameters were the main sources of uncertainty at the beginning, while the harvest scenarios dominated by the end of the simulation period, combined with GCMs and climate scenarios especially in the north. Our regionally explicit uncertainty analysis was found a useful approach to reveal the variability in the regional potentials to reach a policy related, future target level of NBE, which is important information when planning realistic and regionally fair national policy actions.
Trimipramine Photo-Degradation in the Photo-Catalyst Baffled Reactor’s UV/Sulfite/ZnO Redox Reaction System
Authors: Azizi Shohreh , Sarkhosh Maryam , Kamika Ilunga , Mokrani Touhami , Maaza Malik
Published: August 2023

The current work examines UV/Sulfite/ZnO (USZ) in reactor convectional (without baffles) and baffled photocatalytic reactors (BPCR) in order to cost-effectively photo-degrade trimipramine (TIR). The ideal conditions were 2:1:100 Sulfite/ZnO/TRI molar ratio, pH 7, and 30 min of reaction time for 97.4% TRI degradation. In the BPCR reactor, the measured rate constant (kobs) and reaction rate (robs) both rise by around 17% and 50% as the TRI concentration is increased from 50 to 200 mgL−1. The intermediate materials formed in three cases were examined by copper LC. Investigations showed that after 30 min, most of the intermediates became simple linear compounds such as hexane-1, 6-diol (C6H14O2), formaldehyde (CH2O), (E)-prop-1-en-1-yl-l2-azane (C3H6N), acetic acid C2H4O2. Electrical energy consumption (EEO) decreased from 8.61 kWhm3 for convectional reactor to 5.37 kWhm3 for BPCR due to an increase in kobs and robs, for example, 200 mg L−1. As a result, the total cost of the system (TCS) decreased from 3.56 for convectional reactor to 1.22 $ for PCBR reactor. According to information gathered, the UZS procedure lowers the BOD and COD levels by 66 to 86.29% in 80-min reaction time, respectively. Additionally, the BOD/COD ratio starts out at 0.26 and increases to 0.6 after 30 min.
Improving Simplicia of Kerangas Forest by Minimizing Microbial Content Under Ultraviolet Radiation Treatment
Authors: Kissinger  , Huldani Huldani , Nasrulloh Amar V.
Published: August 2023

Kerangas forest is known as a source of traditional medicinal plants and thus potentially the source of simplicia. Medicinal plant preparations of simplicia are usually dried to meet water content standards (< 10%). However, in some cases the drying process carried out still does not eliminate the microbial content in the simplicia. This study aims to analyze the phytochemical compounds contained in three types of medicinal plant simplicia and the total microbial content by treatment with ultraviolet (UV) irradiation. The types of simplicia used were Baeckea frutescens leaves, Shorea balangeran bark and Vitex pubescens leaves (obtained from the kerangas forest). Before testing the total microbial content, simplicia first received UV irradiation. The first simplicia sample was not irradiated, while the next simplicia sample was given UV irradiation with a power of 60 watts and an irradiation time of 1, 2 and 4 h. The microbial content test used the total plate count method with the pour plate analysis technique. S. balangeran is unexposed species to microbes, even without UV irradiation. Radiation with a UV lamp for 1 h with a lamp power of 60 watts and a distance of the sample with a lamp of 30 cm effectively eliminates microbes in B. frutescens simplicia. Radiation for 4 h with a UV lamp of 60 watts and a sample distance of 30 cm was only able to eliminate the microbial content in V. pubescens simplicia. The results of this study indicate that S. balangeran has high potential to be developed as an antibacterial.
Survey and Explorations of the Prehistoric Sites in the Highlands of Southwest Angola
Authors: de Matos Daniela , Nora David , Francisco Rui , Fernandes José , Neto Manuel Sahando , Robakiewicz Elena
Published: August 2023

The area of the escarpment of Angola between Namib and Huíla Province, about 150 km from the Atlantic coast, yields abundant evidence for human activity throughout the Stone Age. There is a high concentration of open-air sites with stone tools classified as Early (ESA) and Middle Stone Age (MSA) by past explorers. At the top of the plateau, the Chela group rocks and particularly the Leba dolomites yield a series of caves and fissures infilled with deposits ranging from the Early Pleistocene to recent times. Considering, the background information, a new project was developed to establish new proxies, we set out to revise this cultural landscape and set the stage for archaeological testing of Stone Age sites. In 2018–2019, our survey documented 45 sites including caves, rock shelters, and open-air locations with evidence of fossil and cultural deposits, including Middle and Later Stone Age (LSA) stone artifacts, faunal remains, pottery, and human burials. A complete map of distribution of caves and their underground topography is presented. Active and fossil speleothems, important for paleoclimatic reconstructions and absolute dating, were found at the caves of Malola and Tchivinguiro. Fossil occurrences were relocated at Tchíua and Cangalongue. Our study shows there is intense recent activity, historical remains, and the use of at least of three caves as burial sites of past herding populations living at the Humpata plateau. Our field assessment shows there is potential to pursue several lines of evidence to reconstruct past human lifeways and environments in this region.
Sharing Positive Affective States Amongst Rodents
Authors: Michon Frédéric , Packheiser Julian , Gazzola Valeria , Keysers Christian
Published: August 2023

Group living is thought to benefit from the ability to empathize with others. Much attention has been paid to empathy for the pain of others as an inhibitor of aggression. Empathizing with the positive affect of others has received less attention although it could promote helping by making it vicariously rewarding. Here, we review this latter, nascent literature to show that three components of the ability to empathize with positive emotions are already present in rodents, namely, the ability to perceive, share, and prefer actions that promote positive emotional states of conspecifics. While it has often been argued that empathy evolved as a motivation to care for others, we argue that these tendencies may have selfish benefits that could have stabilized their evolution: approaching others in a positive state can provide information about the source of valuable resources; becoming calmer and optimistic around animals in a calm or positive mood can help adapt to the socially sensed safety level in the environment; and preferring actions also benefiting others can optimize foraging, reduce aggression, and trigger reciprocity. Together, these findings illustrate an emerging field shedding light on the emotional world of rodents and on the biology and evolution of our ability to cooperate in groups.
Developing persuasive systems for marketing: the interplay of persuasion techniques, customer traits and persuasive message design
Authors: Braca Annye , Dondio Pierpaolo
Published: August 2023

This paper presents a comprehensive review of persuasion techniques and their applications in the context of designing persuasive communication systems for marketing purposes. The study provides a condensed taxonomy of techniques and offers examples to guide the development of effective persuasive messages. Furthermore, the paper explores how attitudes, personality traits, and emotions can be leveraged as input data in predictive models, including machine learning approaches. The study’s findings offer valuable insights for the design and implementation of persuasive communication systems across diverse contexts, including marketing and advertising, public health campaigns, and political messaging. This paper has the potential to serve as a valuable resource for both researchers and practitioners seeking to enhance their understanding of the science of persuasion, as it synthesizes existing literature and provides practical examples. In this way, the paper contributes to the field of persuasion research and practice, serving as a valuable tool for those seeking to expedite and deepen their knowledge of persuasive communication.
Novel object recognition test as an alternative approach to assessing the pharmacological profile of sigma-1 receptor ligands
Authors: Szczepańska Katarzyna , Bojarski Andrzej J. , Popik Piotr , Malikowska-Racia Natalia
Published: August 2023

Background

Although the terms “agonist” and “antagonist” have been used to classify sigma-1 receptor (σ1R) ligands, an unambiguous definition of the functional activity is often hard. In order to determine the pharmacological profile of σ1R ligands, the most common method is to assess their potency to alleviate opioid analgesia. It has been well established that σ1R agonists reduce opioid analgesic activity, while σ1R antagonists have been demonstrated to enhance opioid analgesia in different pain models.

Methods

In the present study, we evaluated the pharmacological profile of selected σ1R ligands using a novel object recognition (NOR) test, to see if any differences in cognitive functions between σ1R agonists and antagonists could be observed. We used the highly selective PRE-084 and S1RA as reference σ1R agonist and antagonist, respectively. Furthermore, compound KSK100 selected from our ligand library was also included in this study. KSK100 was previously characterized as a dual-targeting histamine H3/σ1R antagonist with antinociceptive and antiallodynic activity in vivo. Donepezil (acetylcholinesterase inhibitor and σ1R agonist) was used as a positive control drug.

Results

Both tested σ1R agonists (donepezil and PRE-084) improved learning in the NOR test, which was not observed with the σ1R antagonists S1RA and KSK100.

Conclusions

The nonlinear dose–response effect of PRE-084 in this assay does not justify its use for routine assessment of the functional activity of σ1R ligands.

Graphical Abstract
An Object Association Matching Method Based on V2I System
Authors: Jin Wujie , Yan Lixin , Jiang Junfeng
Published: August 2023

Vehicle-to-infrastructure (V2I) is one of the effective ways to solve the problem of intelligent connected vehicle perception, and the core is to fuse the information sensed by vehicle sensors with that sensed by infrastructure sensors. However, accurately matching the objects detected by the vehicle with multiple objects detected by the infrastructure remains a challenge. This paper presents an object association matching method to fuse the object information from vehicle sensors and roadside sensors, enabling the matching and fusion of multiple target information. The proposed object association matching algorithm consists of three steps. First, the deployment method for vehicle sensors and roadside sensors is designed. Then, the laser point cloud data from the roadside sensors are processed using the DBSCAN algorithm to extract the object information on the road. Finally, an improved single-pass algorithm for object association matching is proposed to achieve the matched target by setting a change threshold for selection. To validate the effectiveness and feasibility of the proposed method, real-vehicle experiments are conducted. Furthermore, the improved single-pass algorithm is compared with the classical Hungarian algorithm, Kuhn–Munkres (KM) algorithm, and nearest neighbor (NN) algorithm. The experimental results demonstrate that the improved single-pass algorithm achieves a target trajectory matching accuracy of 0.937, which is 6.60%, 1.85%, and 2.07% higher than the above-mentioned algorithms, respectively. In addition, this paper investigates the curvature of the target vehicle trajectory data after fusing vehicle sensing information and roadside sensing information. The curvature mean, curvature variance, and curvature standard deviation are analyzed. The experimental results illustrate that the fused target information is more accurate and effective. The method proposed in this study contributes to the advancement of the theoretical system of V2I cooperative perception and provides theoretical support for the development of intelligent connected vehicles.
Statin Treatment on Cardiovascular Risk After Retinal Artery Occlusion: A Historical Cohort Study
Authors: Yoo Joonsang , Jeon Jimin , Shin Joo Youn , Baik Minyoul , Kim Jinkwon
Published: August 2023

Introduction

Retinal artery occlusion (RAO) is a major cause of acute visual loss and patients with RAO have an increased risk for subsequent cardiovascular events. However, there is little evidence of whether the use of statins is associated with the prevention of cardiovascular events in patients with RAO. We investigated whether statin treatment in patients with RAO is associated with a lower risk of cardiovascular events.

Methods

This study was a historical cohort study with nested case–control analysis. Using the nationwide health insurance claims database in Korea, we retrospectively established a cohort of newly diagnosed RAO patients without prior cardiovascular events between January 2008 and March 2020. We defined the case group as those who had cardiovascular events (stroke or myocardial infarction) and the control group as RAO patients without primary outcome matched by sex, age, comorbidities, and duration of follow-up (1:2 incidence density sampling). Conditional logistic regression was performed.

Results

Among 13,843 patients newly diagnosed with RAO, 1030 patients had cardiovascular events (mean follow-up period of 6.4 ± 3.7 years). A total of 957 cases were matched to 1914 controls. Throughout the study period, the proportion of patients taking statin was less than half. Statin treatment after RAO was associated with a low risk of cardiovascular events (adjusted OR, 0.637; 95% CI 0.520–0.780; P < 0.001). A longer duration of statin exposure was associated with a lower cardiovascular risk.

Conclusions

In patients with newly diagnosed RAO, treatment with statins, particularly long-term use, was associated with a low risk of future cardiovascular events.
Enhancing Educators' Theoretical and Practical Understandings of Critical Literacy
Authors: Sotirovska Vera , Vaughn Margaret
Published: August 2023

This Element explores ways to promote critical literacy in teacher education. First, the authors define critical literacy in the context of teacher education through established theoretical frameworks and models of critical literacy pedagogy and share their collective findings on critical literacy research over the course of a decade. Building from these theoretical understandings of critical literacy, they outline ways to actualize critical literacy in teacher education as a transformative pedagogy coupled with resources and activities that support equitable teaching practices. Next, they illustrate how adaptive teaching supports critical literacy pedagogy and underscore autoethnography as a reflective tool to engage pre-service teachers in critical literacy practice. They model this approach with mentor text analyses using critical literacy as a lens to facilitate critically-oriented mindsets in teachers through visioning. They conclude with implications for classroom practice at the intersections of critical literacy and teacher preparation and provide directions for future research.
Creative Sign Language
Authors: Sutton-Spence Rachel , Machado Fernanda de Araújo
Published: August 2023

This Element describes creative sign language in deaf literature. To showcase the exciting developments in Latin American deaf literature, the authors focus upon creative Libras as it is used by the Brazilian deaf community, while emphasising aspects of Libras literature that can be seen in similar productions and performances in sign language literatures around the world. Throughout the Element, the authors refer to examples of Libras poems and stories to give readers a practical experience of appreciating works of creative sign language. They describe Libras literature within its historical and social contexts and consider questions of performance, filming and editing and the potential for written Libras literature. Drawing on anthologies of Libras poems, jokes and stories, they use close-reading techniques to show how the literary effects are created, while reminding the reader that sign language literature cannot be separated from the deaf community.
On Beamforming of DAS Ambient Noise Recorded in an Urban Environment and Rayleigh‐To‐Love Wave Ratio Estimation
Authors: Zhao Yumin , Li Yunyue E. , Li Bei
Published: August 2023

Ambient noise sources in urban environments are generally not perfectly uniformly distributed or travel exactly along the axial direction of the receiver array. The horizontally deployed distributed acoustic sensing (DAS) fiber‐optic cable is able to record both Rayleigh and Love waves. Therefore, resolving the source propagation direction and the content of Rayleigh and Love waves from the DAS ambient noise data is essential to resolve a reliable near‐surface shear‐wave velocity model. However, a standard geophone‐based beamforming procedure may not apply to DAS ambient noise data due to the complex measurements of DAS. To address this issue, we investigate the validity of beamforming results by analyzing the simulated seismic ambient noise recorded by a DAS array close to an L‐shape under different source conditions. Synthetic examples demonstrate the importance of correcting amplitude imbalances and polarity reversals in the DAS ambient noise data to ensure a reliable beamforming analysis. In addition, we estimate the Rayleigh‐to‐Love wave (R/L) ratio from the DAS ambient noise data with the resolved source direction, the known array geometry, and the measured amplitude information. Finally, we apply the method to two 2 min DAS ambient noise data recorded by the Stanford DAS Array‐1. The results suggest that the analyzed data were mainly generated from the local traffic and dominated by Love waves.
Suture Reactivation, Slip Partitioning, and a Protracted Strike‐Slip Rate Gradient in the Denali Fault System, Southern Alaska, USA
Authors: Waldien T. S. , Roeske S. M. , Chatterjee R. , O’Sullivan P. B. , Stockli D. F.
Published: August 2023

Active strike‐slip fault systems commonly display along‐strike Quaternary slip rate gradients associated with fault bends and splay faults, which generate surface uplift by dip‐slip faulting or distributed “off fault” deformation. By analogy, the documentation of long‐term (107 yr) slip gradients on some continental strike‐slip fault systems implies long‐term coevolution of strike‐slip and dip‐slip fault systems. Here we leverage the observed ≥33 Myr right‐lateral slip gradient on the Denali fault, Alaska, USA to investigate the role of splay thrust systems in accommodating the slip gradient. We focus on the Broxson Gulch thrust system, which splays southwestward from the Denali fault in the eastern Alaska Range. Apatite and zircon (U‐Th)/He and fission‐track cooling ages from metasedimentary and metaplutonic rocks intersected by the thrust system record an along‐strike decrease in cooling ages commensurate with an increase in late Oligocene‐Neogene bedrock exhumation and shortening with proximity to the Denali fault. The dominant structure in the Broxson Gulch thrust system is the Valdez Creek fault, which is an upper crustal reactivation of the Valdez Creek shear zone–the main Late Cretaceous suture between western North America and outboard accreted arc terranes. After reactivation of the Valdez Creek shear zone at ca. 30 Ma, the thrust system grew by south‐vergent imbrication of the upper crust along thrust and reverse faults until at least 6 Ma. Incorporating results from the Broxson Gulch thrust system into the regional structural evolution of the Denali fault system reveals significant spatiotemporal heterogeneity in shortening adjacent to the Denali fault. Moreover, nearly all of the late Oligocene‐Neogene shortening south of the Denali fault was focused along reactivated terrane boundaries inherited from Mesozoic assembly of the North American Cordillera, and the spatial distribution of the inherited structures appears to control slip partitioning behavior of the Denali fault system across time scales ranging from 101 (historic seismicity) to 107 yr. The slip partitioning behavior of the Denali fault system highlights the mechanical importance of inherited structures leading to protracted shortening on splay thrust systems, which siphon slip from the master strike‐slip fault. We contend that the weakness of nearby reactivated terrane boundaries should be considered among other mechanisms commonly evoked to explain the partitioning behavior of continental strike‐slip fault systems (e.g., stress field rotation, obliquity angle, and strength of master strike‐slip fault).
More Snow Accelerates Legacy Carbon Emissions From Arctic Permafrost
Authors: Pedron S. A. , Jespersen R. G. , Xu X. , Khazindar Y. , Welker J. M. , Czimczik C. I.
Published: August 2023

Snow is critically important to the energy budget, biogeochemistry, ecology, and people of the Arctic. While climate change continues to shorten the duration of the snow cover period, snow mass (the depth of the snow pack) has been increasing in many parts of the Arctic. Previous work has shown that deeper snow can rapidly thaw permafrost and expose the large amounts of ancient (legacy) organic matter contained within it to microbial decomposition. This process releases carbonaceous greenhouse gases but also nutrients, which promote plant growth and carbon sequestration. The net effect of increased snow depth on greenhouse gas emissions from Arctic ecosystems remains uncertain. Here we show that 25 years of snow addition turned tussock tundra, one of the most spatially extensive Arctic ecosystems, into a year‐round source of ancient carbon dioxide. More snow quadrupled the amount of organic matter available to microbial decomposition, much of it previously preserved in permafrost, due to deeper seasonal thaw, soil compaction and subsidence as well as the proliferation of deciduous shrubs that lead to 10% greater carbon uptake during the growing season. However, more snow also sustained warmer soil temperatures, causing greater carbon loss during winter (+200% from October to May) and year‐round. We find that increasing snow mass will accelerate the ongoing transformation of Arctic ecosystems and cause earlier‐than‐expected losses of climate‐warming legacy carbon from permafrost.
Estimating Reservoir Sedimentation Rates and Storage Capacity Losses Using High‐Resolution Sentinel‐2 Satellite and Water Level Data
Authors: Yao Fangfang , Minear J. Toby , Rajagopalan Balaji , Wang Chao , Yang Kehan , Livneh Ben
Published: August 2023

In nearly all reservoirs, storage capacity is steadily lost due to trapping and accumulation of sediment. Despite critical importance to freshwater supplies, reservoir sedimentation rates are poorly understood due to sparse bathymetry survey data and challenges in modeling sedimentation sequestration. Here, we proposed a novel approach to estimate reservoir sedimentation rates and storage capacity losses using high‐resolution Sentinel‐2 satellites and daily in situ water levels. Validated on eight reservoirs across the central and western United States, the estimated reservoir bathymetry and sedimentation rates have a mean error of 4.08% and 0.05% yr−1, respectively. Estimated storage capacity losses to sediment vary among reservoirs, which overall agrees with the pattern from survey data. We also demonstrated the potential applications of the proposed approach to ungauged reservoirs by combining Sentinel‐2 with sub‐monthly water levels from recent satellite altimeters.
Limited Shallow Slip for the 2020 Simeonof Earthquake, Alaska, Constrained by GNSS‐Acoustic
Authors: DeSanto John B. , Webb Spahr C. , Nooner Scott L. , Schmidt David A. , Crowell Brendan W. , Brooks Benjamin A. , Ericksen Todd L. , Chadwell C. David
Published: August 2023

The 22 July 2020 Mw7.8 Simeonof earthquake was a deep megathrust event that ruptured along the Shumagin segment of the Alaska‐Aleutian subduction zone. This earthquake occurred ∼250 km from a seafloor geodetic GNSS‐Acoustic site IVB1, where we observed a velocity of 3.78 ± 1.15 cm/yr with the down‐going slab prior to the earthquake followed by 0.6 ± 0.7 eastward and −15.5 ± 0.8 cm northward coseismic offset. We computed a slip model of the coseismic rupture using the static offset at IVB1 alongside regional continuous GNSS and strong motion stations. The small static horizontal offset at the site precludes significantly shallower rupture than previously inferred from terrestrial observations, confirming that the Simeonof earthquake was a deep megathrust earthquake. The observed site velocity implies partial locking prior to the earthquake, implying significant shallow strain accumulation such that the small coseismic offset is unlikely to have relieved all of the accumulated strain since the last coseismic rupture.
Whistler‐Mode Waves in Magnetic Ducts
Authors: Streltsov Anatoly V. , Nejad Salman A.
Published: August 2023

Observations from the NASA Magnetospheric Multiscale (MMS) satellites show packages of extremely low frequency (ELF) whistler‐mode waves localized inside the small‐scale irregularities of the magnetic field. These irregularities are formed by the narrow field‐aligned channels where the magnitude of the background magnetic field inside the channel is greater or less than outside. By analogy with the classical density ducts, we introduce the high‐B duct, where the magnitude of the field inside the channel is greater than the outside, and the low‐B duct, where the magnitude of the field inside the channel is less than the outside. We investigate the guiding of the ELF whistler‐mode waves by high‐B and low‐B ducts. We derive the analytical criteria for the wave ducting by these ducts and confirm them with two‐dimension, time‐dependent simulations of the electron‐MHD model. Also, we model ELF whistler‐mode waves observed inside the high‐B and low‐B ducts by MMS satellites.
Impact of Hypocenter Location on Rupture Extent and Ground Motion: A Case Study of Southern Cascadia
Authors: Chan Yuk Po Bowie , Yao Suli , Yang Hongfeng
Published: August 2023

The Cascadia subduction zone has well‐documented geological records of megathrust earthquakes with the latest ∼Mw 9 rupture occurring in CE 1700. The paleoseismic observations suggest that southern Cascadia is mature for future earthquakes since the last event. Consequently, it is crucial to investigate the potential rupture scenarios. Although existing interseismic locking models share similar moment deficits, whether future earthquakes would be margin‐wide or segmented, as suggested by paleoseismic records, remains unknown. Accordingly, we aim to investigate: (a) possible rupture segmentation patterns, (b) whether south Cascadia can host margin‐wide ruptures, and (c) whether the existing locking models suggest similar future rupture scenarios. Assuming constant effective normal stress, we estimate the stress distribution constrained by the locking models (i.e., Gamma model from Schmalzle et al. (2014, https://doi.org/10.1002/2013GC005172), the preferred model from S. Li et al. (2018, https://doi.org/10.1029/2018JB015620), and the best‐fit model from Lindsey et al. (2021, https://doi.org/10.1038/s41561-021-00736-x)) from static calculation and discover they lead to different stress distributions, indicating distinct seismic potentials. Our dynamic rupture scenarios show that the south can generate both segmented ruptures (>Mw 7.3–8.4) and margin‐wide ruptures (>Mw 8.6) depending on the hypocenter location. The along‐strike rupture length appears to coincide with rupture lengths hypothesized from paleoseismology, and the Schmalzle model produces reasonable coastal subsidence amplitudes from the CE 1700 event. Therefore, we propose that three high‐slip trench‐breaching patches are sufficient for reproducing historical subsidence records. Our results can be further applied in seismic and tsunami hazard assessment, and serve as a comparison for non‐trench‐breaching scenarios.
Evaluating and Improving TROPICS Millimeter‐Wave Sounder's Precipitation Estimate Over Ocean
Authors: You Yalei , Huffman George , Kidd Chris , Braun Scott , Blackwell William , Yang John Xun , Da Cheng
Published: August 2023

This paper examines precipitation retrievals from Kidd et al. (2022, https://doi.org/10.3390/rs14132992) by applying the Precipitation Retrieval and Profiling Scheme to data observed by the NASA Time‐Resolved Observations of Precipitation structure and storm Intensity with a Constellation of Smallsats (TROPICS) Millimeter‐wave Sounder (TMS) onboard the TROPICS Pathfinder satellite, a precursor to the TROPICS mission. We first compare the TMS precipitation retrieval performance over ocean with those from seven current operational passive microwave radiometers, including four conical scanning sensors [Special Sensor Microwave Imager/Sounders (SSMISs) onboard F16/F17/F18 satellites, and Advanced Microwave Scanning Radiometer 2 (AMSR2)] and three cross track scanning sensors [Microwave Humidity Sounders onboard NOAA19 and MetOpB satellites, and the Advanced Technology Microwave Sounder onboard the National Polar‐orbiting Partnership satellite], using precipitation estimates from Global Precipitation Measurement Mission Microwave Imager (GMI) as the reference. We show that TMS performs similarly to the current operational cross track scanning sensors, while worse than conical scanning sensors largely due to the lack of low frequency channels (e.g., 19 GHz). Second, we create an adjusted TMS precipitation retrievals by combining the original TMS precipitation and the precipitation propagated from AMSR2 and SSMISs to the time/location of the TMS overpass, using our previously developed microwave‐to‐microwave propagation technique. Results show that the adjusted TMS precipitation performs better than the original TMS estimates. For example, the correlation of the original TMS and GMI estimates is 0.35 but increases to 0.49 when the adjusted TMS result is compared to GMI. The propagation technique lays the foundation to improve TMS precipitation when incorporating them into level‐3 merged products.
Combined Impacts of the Pacific Decadal Oscillation and Atlantic Multidecadal Oscillation on Summer Precipitation in Eastern China During the Medieval Climate Anomaly and Little Ice Age
Authors: Ge Yucen , Miao Jiapeng , Lang Xianmei , Si Dong , Jiang Dabang
Published: August 2023

We investigate the joint effects of the Pacific Decadal Oscillation (PDO) and Atlantic Multidecadal Oscillation (AMO) on eastern China summer precipitation (ECSP) during two typical periods in the last millennium [i.e., the Medieval Climate Anomaly (MCA) and the Little Ice Age (LIA)] using simulations from five selected climate models. The multimodel mean indicates that the ECSP anomalies under the four combined AMO and PDO phases differ between the MCA and the LIA. During the MCA, the meridional wave train induced by the PDO‐related convective heating over the northwestern Pacific is dominant and the zonal wave train related to the AMO is secondary. Independent of the AMO phase, deficient precipitation appears over South China in both PDO+ phases and vice versa. Meanwhile, most areas north of the Yangtze River valley feature positive anomalies in the PDO+/AMO+ phase but deficits in the PDO+/AMO− phase. In comparison, the Huanghe‐Huaihe River valley and southern Northeast China receive excessive and deficient precipitation in the PDO−/AMO+ and PDO−/AMO− phases, respectively. During the LIA, the zonal wave train induced by the AMO locates more southeastward than that during the MCA and has an overwhelming impact on the ECSP. Specifically, regardless of the PDO phase, excessive ECSP exists over Northeast China and South China in both AMO+ phases and vice versa. Moreover, precipitation between the two regions is excessive when the PDO is in phase with the AMO but deficient when they are out of phase.
Peculiar Wave Structure of the Mesospheric Sporadic Sodium Layer Observed by Lidars in Hefei (31.8°N, 117.3°E) and Wuhan (30.5°N, 114°E), Central China
Authors: Shi Mengxi , Qiu Shican , Soon Willie , Velasco Herrera Victor Manuel , Xue Xianghui , Li Tao , Dou Xiankang
Published: August 2023

Lidar observations are an effective tracker for identifying atmospheric wave signals. In this research, observations through three lidars are utilized to study the wave structures. A broadband sodium fluorescence lidar and a narrowband Temperature/Wind (T/W) lidar located at Hefei (31.8°N, 117.3°E), while the third lidar system, a broadband lidar system, is located in Wuhan (30.5°N, 114.4°E), about 310 km from Hefei. The three lidars can observe sodium density, temperature and wind profiles simultaneously. Joint sodium density measurements by the fourth lidar beams from Wuhan and Hefei yield a peculiar NaS with distinguished C‐structure and a large horizontal scale of wave structure over more than 310 km, on 21 December 2014. The NaS event occurring at 14:20 to 17:50 UT corresponds well to the region where the Richardson Number (Ri) is larger than 10, which in turn indicates that the NaS was formed in an extremely stable atmosphere. Results from the Lomb‐Scargle periodogram analysis suggest that the occurrence and evolution of this NaS event may have been caused by a gravity wave with a period of about 1.25 hr, and its end is closely related to the gravity wave fragmentation caused by convective instability.
Glucocorticoid receptor-induced non-muscle caldesmon regulates metastasis in castration-resistant prostate cancer
Authors: Virtanen Verneri , Paunu Kreetta , Kukkula Antti , Niva Saana , Junila Ylva , Toriseva Mervi , Jokilehto Terhi , Mäkelä Sari , Huhtaniemi Riikka , Poutanen Matti , Paatero Ilkka , Sundvall Maria
Published: August 2023

Lethal prostate cancer (PCa) is characterized by the presence of metastases and development of resistance to therapies. Metastases form in a multi-step process enabled by dynamic cytoskeleton remodeling. An actin cytoskeleton regulating gene, CALD1, encodes a protein caldesmon (CaD). Its isoform, low-molecular-weight CaD (l-CaD), operates in non-muscle cells, supporting the function of filaments involved in force production and mechanosensing. Several factors, including glucocorticoid receptor (GR), have been identified as regulators of l-CaD in different cell types, but the regulation of l-CaD in PCa has not been defined. PCa develops resistance in response to therapeutic inhibition of androgen signaling by multiple strategies. Known strategies include androgen receptor (AR) alterations, modified steroid synthesis, and bypassing AR signaling, for example, by GR upregulation. Here, we report that in vitro downregulation of l-CaD promotes epithelial phenotype and reduces spheroid growth in 3D, which is reflected in vivo in reduced formation of metastases in zebrafish PCa xenografts. In accordance, CALD1 mRNA expression correlates with epithelial-to-mesenchymal transition (EMT) transcripts in PCa patients. We also show that CALD1 is highly co-expressed with GR in multiple PCa data sets, and GR activation upregulates l-CaD in vitro. Moreover, GR upregulation associates with increased l-CaD expression after the development of resistance to antiandrogen therapy in PCa xenograft mouse models. In summary, GR-regulated l-CaD plays a role in forming PCa metastases, being clinically relevant when antiandrogen resistance is attained by the means of bypassing AR signaling by GR upregulation.
SLC26A3/NHERF2-IκB/NFκB/p65 feedback loop suppresses tumorigenesis and metastasis in colorectal cancer
Authors: Lin Chunlin , Lin Penghang , Lin Huayan , Yao Hengxin , Liu Songyi , He Ruofan , Chen Hui , Teng Zuhong , Hoffman Robert M. , Ye Jianxin , Zhu Guangwei
Published: August 2023

Colorectal cancer (CRC) is a formidable disease due to the intricate mechanisms that drive its proliferation and metastasis. Despite significant progress in cancer research, the integration of these mechanisms that influence cancer cell behavior remains elusive. Therefore, it is imperative to comprehensively elucidate the underlying mechanisms driving CRC proliferation and metastasis. In this study, we reported a novel role of SLC26A3 in suppressing CRC progression. We found that SLC26A3 expression was downregulated in CRC, which was proportionally correlated with survival. Our in vivo and in vitro experiments demonstrated that up-regulation of SLC26A3 inhibited CRC proliferation and metastasis, while down-regulation of SLC26A3 promoted CRC progression by modulating the expression level of IκB. Furthermore, we identified NHERF2 as a novel interacting protein of SLC26A3 responsible for stabilizing the IκB protein and removing ubiquitination modification. Mechanistically, SLC26A3 augmented the interaction between NHERF2 and IκB, subsequently reducing its degradation. This process inhibited the dissociation of p65 from the IκB/p65/p50 complex and reduced the translocation of p65 from the cytoplasm to the nucleus. Moreover, our investigation revealed that NF-κB/p65 directly bound to the promoter of SLC26A3, leading to a decline in its mRNA expression. Thus, SLC26A3 impeded the nuclear translocation of NF-κB/p65, enhancing the transcription of SLC26A3 and establishing a positive regulatory feedback loop in CRC cells. Collectively, these results suggest that a SLC26A3/NHERF2-IκB/NF-κB/p65 signaling loop suppresses proliferation and metastasis in CRC cells. These findings propose a novel SLC26A3-driven signaling loop that regulates proliferation and metastasis in CRC, providing promising therapeutic interventions and prognostic targets for the management of CRC.
Therapeutic hypothermia modulates the neurogenic response of the newborn piglet subventricular zone after hypoxia-ischemia
Authors: Alonso-Alconada Daniel , Gressens Pierre , Golay Xavier , Robertson Nicola J.
Published: August 2023

Background

Neuroprotection combined with neuroregeneration may be critical for optimizing functional recovery in neonatal encephalopathy. To investigate the neurogenic response to hypoxia-ischemia (HI) followed by normothermia (38.5 °C) or three different hypothermic temperatures (35, 33.5, or 30 °C) in the subventricular zone (SVZ) of the neonatal piglet.

Methods

Following transient cerebral HI and resuscitation, 28 newborn piglets were randomized to: normothermia or whole-body cooling to 35 °C, 33.5 °C, or 30 °C during 2–26 h (all n = 7). At 48 h, piglets were euthanized and SVZ obtained to evaluate its cellularity, pattern of cell death, radial glia length, doublecortin (DCX, neuroblasts) expression, and Ki67 (cell proliferation) and Ki67/Sox2 (neural stem/progenitor dividing) cell counts.

Results

Normothermic piglets showed lower total (Ki67+) and neural stem/progenitor dividing (Ki67+Sox2+) cell counts when compared to hypothermic groups. Cooling to 33.5 °C obtained the highest values of SVZ cellularity, radial glia length processes, neuroblast chains area and DCX immunohistochemistry. Cooling to 30 °C, however, revealed decreased cellularity in the lateral SVZ and shorter radial glia processes when compared with 33.5 °C.

Conclusions

In a neonatal piglet model, hypothermia to 33.5 °C modulates the neurogenic response of the SVZ after HI, highlighting the potential beneficial effect of hypothermia to 33.5 °C on endogenous neurogenesis and the detrimental effect of overcooling beyond this threshold.

Impact

Neuroprotection combined with neuroregeneration may be critical for optimizing functional recovery in neonatal encephalopathy.

Hypothermia may modulate neurogenesis in the subventricular zone (SVZ) of the neonatal hypoxic-ischemic piglet.

Cooling to 33.5 °C obtained the highest values of SVZ cellularity, radial glia length processes, neuroblast chains area and doublecortin immunohistochemistry; cooling to 30 °C, however, revealed decreased cellularity and shorter radial glia processes.

In a neonatal piglet model, therapeutic hypothermia (33.5 °C) modulates the neurogenic response of the SVZ after hypoxia-ischemia, highlighting also the detrimental effect of overcooling beyond this threshold.
Comparison of two inspiratory muscle training protocols in people with spinal cord injury: a secondary analysis
Authors: Palermo Anne E. , Butler Jane E. , Boswell-Ruys Claire L.
Published: August 2023

Study design/setting

Secondary analysis.

Objectives

To compare the change in maximal inspiratory pressure (PImax) over the first 4 weeks of two different inspiratory muscle training (IMT) protocols and explore if either method is more effective for people with spinal cord injury.

Methods

Data originated from two published studies. Participants completed flow-resistive IMT (F-IMT) at 80% daily PImax, 7 days/week (supervised weekly), or threshold IMT (T-IMT) at 30–80% weekly PImax, twice-daily, 5 days/week (supervised every session). Seven participants from each trial were matched by training adherence, level of spinal cord injury, impairment grade (A–C), and height. Differences between F-IMT and T-IMT groups in training intensity, breaths taken, inspiratory work, and the change in the PImax from baseline at the end of week four were analysed.

Results

Over 4 weeks, there was no difference in the change in PImax between groups (Absolute change in PImax (cmH2O): p = 0.456, Percent change in PImax relative to baseline: p = 0.128). F-IMT participants trained at a higher intensity (median: 77 vs 22 cmH2O, p = 0.001 and 80% baseline vs 61% baseline, p = 0.038) but took fewer breaths (840 vs 1404 breaths, p = 0.017) than T-IMT participants. Inspiratory work was similar between groups (64,789 vs 65,910 (% PImax × number of breaths), p = 0.535).

Conclusions

Our findings support both methods of IMT as the change in PImax and inspiratory work were similar between groups. However, daily high-intensity F-IMT with intermittent supervision, required fewer breaths and less participant and therapist time. Future studies should examine optimal dosage and supervision required to achieve increased PImax.
Current incidence, severity, and management of veno-occlusive disease/sinusoidal obstruction syndrome in adult allogeneic HSCT recipients: an EBMT Transplant Complications Working Party study
Authors: Ruutu Tapani , Peczynski Christophe , Houhou Mohamed , Polge Emmanuelle , Mohty Mohamad , Kröger Nicolaus , Moiseev Ivan , Penack Olaf , Salooja Nina , Schoemans Hélène , Duarte Rafael F. , Schroeder Thomas , Passweg Jakob , Wulf Gerald G. , Ganser Arnold , Sica Simona , Arat Mutlu , Salmenniemi Urpu , Broers Annoek E. C. , Bourhis Jean Henri , Rambaldi Alessandro , Maertens Johan , Halaburda Kazimierz , Zuckerman Tsila , Labussière-Wallet Hélène , Basak Grzegorz , Koenecke Christian , Perić Zinaida
Published: August 2023

The current incidence, diagnostic policy, management, and outcome of VOD/SOS at EBMT centers were studied. All centers that had performed allogeneic HSCTs in adult patients within one defined year were invited to the study. Seventy-one centers participated with a total of 2886 allogeneic transplantations and 93 cases of VOD/SOS in 2018. The cumulative incidence of VOD/SOS at day 21 was 1.8% and at day 100 2.4%. Of 67 cases with detailed data, 52 were classical and 15 (22%) late onset (>day 21). According to the EBMT criteria, 65/67 patients had at least two VOD/SOS risk factors. The severity grades were: mild 0, moderate 3, severe 29, very severe 35. Fifty-four patients were treated with defibrotide. VOD/SOS resolved in 58% of the patients, 3/3 with moderate, 22/28 with severe, and 12/33 with very severe grade (p < 0.001). By day 100, 57% of the patients were alive; 3/3 with moderate, 22/29 with severe, and 13/35 with very severe VOD/SOS (p = 0.002). In conclusion, the incidence of VOD/SOS was low. Severe and very severe grades dominated. Very severe grade predicted poor outcome compared to severe grade further supporting the concept of early diagnosis and treatment to avoid a dismal outcome.
LMO2 promotes the development of AML through interaction with transcription co-regulator LDB1
Authors: Lu Lihui , Wang Jianwei , Fang Fang , Guo Ailian , Jiang Shuting , Tao Yanfang , Zhang Yongping , Li Yan , Zhang Kunlong , Zhang Zimu , Zhuo Ran , Chu Xinran , Li Xiaolu , Tian Yuanyuan , Ma Li , Sang Xu , Chen Yanling , Yu Juanjuan , Yang Yang , Cao Haibo , Gao Jizhao , Lu Jun , Hu Shaoyan , Pan Jian , He Hailong
Published: August 2023

One of the characteristics of leukemia is that it contains multiple rearrangements of signal transduction genes and overexpression of non-mutant genes, such as transcription factors. As an important regulator of hematopoietic stem cell development and erythropoiesis, LMO2 is considered an effective carcinogenic driver in T cell lines and a marker of poor prognosis in patients with AML with normal karyotype. LDB1 is a key factor in the transformation of thymocytes into T-ALL induced by LMO2, and enhances the stability of carcinogenic related proteins in leukemia. However, the function and mechanism of LMO2 and LDB1 in AML remains unclear. Herein, the LMO2 gene was knocked down to observe its effects on proliferation, survival, and colony formation of NB4, Kasumi-1 and K562 cell lines. Using mass spectrometry and IP experiments, our results showed the presence of LMO2/LDB1 protein complex in AML cell lines, which is consistent with previous studies. Furthermore, in vitro and in vivo experiments revealed that LDB1 is essential for the proliferation and survival of AML cell lines. Analysis of RNA-seq and ChIP-Seq results showed that LDB1 could regulate apoptosis-related genes, including LMO2. In LDB1-deficient AML cell lines, the overexpression of LMO2 partially compensates for the proliferation inhibition. In summary, our findings revealed that LDB1 played an important role in AML as an oncogene, and emphasize the potential importance of the LMO2/LDB1 complex in clinical treatment of patients with AML.