bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of Primary Immunodeficiency Diseases on the Life Experiences of Patients in Malaysia From the Caregivers’ Perspective: A Qualitative Study
Authors: Ahmed Meelad Ruwaydah , Abd Hamid Intan Juliana , Hashim Ilie Fadzilah , Zainudeen Zarina Thasneem , Abu Bakar Firdaus Farhani , Taib Fahisham , Mohamad Norsarwany , Mangantig Ernest , Ismail Intan Hakimah , Abdul Latiff Amir Hamzah , Mohd Noh Lokman
Published: March 2022

Introduction

Primary immunodeficiency diseases (PIDs) are chronic diseases that affect the various aspects of a patient’s life. However, the impact of living with PIDs is poorly described.

Objective

This study aimed to explore the living experience challenges among the Malaysian caregivers of the patients with PID who underwent a follow-up in the Universiti Sains Malaysia or those registered members of the Malaysian PIDs Society.

Methodology

The study was conducted from March 1 to May 30, 2021. The parents of children with PIDs were invited to participate for a semi-structured in-depth interview at the PID clinics in the USM. The estimated time of each interview was 30 min. The semi-structured interview was performed via a telephone call because of COVID-19 pandemic restrictions. The audio recording of each interview was transcribed and translated from Malay to English. Subsequently, a thematic analysis utilizing the ATLAS.ti software was performed.

Results

The thematic analysis revealed five main themes, which are living with fear and anxiety with four sub-themes (sickness, psychological issues, fear of infections and hereditary issues), PID healthcare support struggles with four sub-themes (PID health system, treatment, diagnosis and financial issues), knowledge with two sub-themes (educational issues and disease understanding), social constraint with two sub-themes (relationships and social isolations) and coping with three sub-themes (acceptance, child health improvement and emotional hygiene).

Conclusion

Living with fear and anxiety is a major theme impacting the living experiences of Malaysian patients with PIDs. Improvements in healthcare delivery and disease education are needed to ensure optimal quality of life.
Therapeutic Alliance and Rapport Modulate Responses to Psilocybin Assisted Therapy for Depression
Authors: Murphy Roberta , Kettner Hannes , Zeifman Rick , Giribaldi Bruna , Kartner Laura , Martell Jonny , Read Tim , Murphy-Beiner Ashleigh , Baker-Jones Michelle , Nutt David , Erritzoe David , Watts Rosalind , Carhart-Harris Robin
Published: March 2022

Background:Across psychotherapeutic frameworks, the strength of the therapeutic alliance has been found to correlate with treatment outcomes; however, its role has never been formally assessed in a trial of psychedelic-assisted therapy. We aimed to investigate the relationships between therapeutic alliance and rapport, the quality of the acute psychedelic experience and treatment outcomes.

Methods:This 2-arm double-blind randomized controlled trial compared escitalopram with psychedelic-assisted therapy for moderate-severe depressive disorder (N= 59). This analysis focused on the psilocybin condition (n= 30), who received two oral doses of 25 mg psilocybin, 3-weeks apart, with psychological preparation, in-session support, and integration therapy. A new psychedelic therapy model, called “Accept-Connect-Embody” (ACE), was developed in this trial. The primary outcome was depression severity 6 weeks post treatment (Quick Inventory of Depressive Symptomatology, QIDS-SR-16). Path analyses tested the hypothesis that therapeutic alliance (Scale To Assess the Therapeutic Relationship Patient Version, STAR-P) would predict depression outcomes via its influence on the acute psychedelic experience, specifically emotional-breakthrough (EBI) and mystical-type experiences (MEQ). The same analysis was performed on the escitalopram arm to test specificity.

Results:The strength of therapeutic alliance predicted pre-session rapport, greater emotional-breakthrough and mystical-type experience (maximum EBI and MEQ scores across the two psilocybin sessions) and final QIDS scores (β= −0.22,R2= 0.42 for EBIMax;β= −0.19,R2= 0.32 for MEQMax). Exploratory path models revealed that final depression outcomes were more strongly affected by emotional breakthrough during the first, and mystical experience during the second session. Emotional breakthrough, but not mystical experience, during the first session had a positive effect on therapeutic alliance ahead of the second session (β= 0.79,p< 0.0001). Therapeutic alliance ahead of the second session had a direct impact on final depression scores, not mediated by the acute experience, with a weaker alliance ahead of the second psilocybin session predicting higher absolute depression scores at endpoint (β= −0.49,p< 0.001)

Discussion:Future research could consider therapist training and characteristics; specific participant factors, e.g., attachment style or interpersonal trauma, which may underlie the quality of the therapeutic relationship, the psychedelic experience and clinical outcomes; and consider how therapeutic approaches might adapt in cases of weaker therapeutic alliance.

Clinical Trial Registration:This trial is registered athttp://clinicaltrials.gov, identifier (NCT03429075).
The Use of Oral Anticoagulation Is Not Associated With a Reduced Risk of Mortality in Patients With COVID-19: A Systematic Review and Meta-Analysis of Cohort Studies
Authors: Dai Meng-Fei , Guo Si-Tong , Ke Yi-Jun , Wang Bao-Yan , Yu Feng , Xu Hang , Gu Zhi-Chun , Ge Wei-Hong
Published: March 2022

Background: Hypercoagulability and thromboembolic events are associated with poor prognosis in coronavirus disease 2019 (COVID-19) patients. Whether chronic oral anticoagulation (OAC) improve the prognosis is yet controversial. The present study aimed to investigate the association between the chronic OAC and clinical outcomes in COVID-19 patients.

Methods: PubMed, Embase, Web of Science, and the Cochrane Library were comprehensively searched to identify studies that evaluated OAC for COVID-19 until 24 July 2021. Random-effects model meta-analyses were performed to pool the relative risk (RR) and 95% confidence interval (CI) of all-cause mortality and intensive care unit (ICU) admission as primary and secondary outcomes, respectively. According to the type of oral anticoagulants [direct oral anticoagulants (DOACs) or vitamin K antagonists (VKAs)], subgroup and interaction analyses were performed to compare DOACs and VKAs. Meta-regression was performed to explore the potential confounders on all-cause mortality.

Results: A total of 12 studies involving 30,646 patients met the inclusion criteria. The results confirmed that chronic OAC did not reduce the risk of all-cause mortality (RR: 0.92; 95% CI 0.82–1.03; p = 0.165) or ICU admission (RR: 0.65; 95% CI 0.40–1.04; p = 0.073) in patients with COVID-19 compared to those without OAC. The chronic use of DOACs did not reduce the risk of all-cause mortality compared to VKAs (Pinteraction = 0.497) in subgroup and interaction analyses. The meta-regression failed to detect any potential confounding on all-cause mortality.

Conclusion: COVID-19 patients with chronic OAC were not associated with a lower risk of all-cause mortality and ICU admission compared to those without OAC, and the results were consistent across DOACs and VKA subgroups.

Systematic Review Registration:clinicaltrials.gov, identifier CRD42021269764.
Medicinal Plant Extracts and Natural Compounds for the Treatment of Cutaneous Lupus Erythematosus: A Systematic Review
Authors: Lubov Janet E. , Jamison Aisha S. , Baltich Nelson Becky , Amudzi Alice A. , Haas Kelly N. , Richmond Jillian M.
Published: March 2022

Cutaneous lupus erythematosus (CLE) is a group of autoimmune connective tissue disorders that significantly impact quality of life. Current treatment approaches typically use antimalarial medications, though patients may become recalcitrant. Other treatment options include general immunosuppressants, highlighting the need for more and more targeted treatment options. The purpose of this systematic review was to identify potential compounds that could be repurposed for CLE from natural products since many rheumatologic drugs are derived from natural products, including antimalarials. This study was registered with PROSPERO, the international prospective register of systematic reviews (registration number CRD42021251048). We comprehensively searched Ovid Medline, Cochrane Library, and Scopus databases from inception to April 27th, 2021. These terms included cutaneous lupus erythematosus; general plant, fungus, bacteria terminology; selected plants and plant-derived products; selected antimalarials; and JAK inhibitors. Our search yielded 13,970 studies, of which 1,362 were duplicates. We screened 12,608 abstracts, found 12,043 to be irrelevant, and assessed 565 full-text studies for eligibility. Of these, 506 were excluded, and 59 studies were included in the data extraction. The ROBINS-I risk of bias assessment tool was used to assess studies that met our inclusion criteria. According to our findings, several natural compounds do reduce inflammation in lupus and other autoimmune skin diseases in studies using in vitro methods, mouse models, and clinical observational studies, along with a few randomized clinical trials. Our study has cataloged evidence in support of potential natural compounds and plant extracts that could serve as novel sources of active ingredients for the treatment of CLE. It is imperative that further studies in mice and humans are conducted to validate these findings.

Systematic Review Registration:https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=251048.
Human Face Perception Using Electroencephalography and Magnetoencephalography
Authors: Miki Kensaku , Takeshima Yasuyuki , Watanabe Shoko , Kakigi Ryusuke
Published: March 2022

The face has a large amount of information that is useful for humans in social communication. Recently, non-invasive methods have been used to investigate human brain activity related to perception and cognition processes. Electroencephalography (EEG) and magnetoencephalography (MEG) have excellent temporal resolution and reasonably good spatial resolution. Therefore, they are useful to investigate time sequences of human brain activity related to the face perception process. In this review, we introduce our previous EEG and MEG studies of human face perception that demonstrated the following characteristics of face perception processing: (1) Event-related components in the temporal area related to the activity in the inferior temporal (IT) area, corresponding to the fusiform face area (FFA), are evoked approximately 180 msec after the presentation of a face. The activity in the IT area plays an important role in the detection processing of a face, and the contours of a face affect the activity in the IT areas. (2) Event-related components in the temporal area related to the superior temporal sulcus (STS) activity are larger when eyes are averted than when directly looking into the eyes. (3) The direction of features of a face affects the face perception processing in the right hemisphere. On the other hand, the matching of the direction between the contours and features of a face affects the processing in the left hemisphere. (4) Random dots blinking (RDB), which uses temporal changes in patterns of many small dots to present stimuli without a change in luminance during the presentation of a face, is a useful visual stimulus method to investigate the brain activity related to face perception processing in the IT area using EEG and MEG.
The Neuropeptide α-Calcitonin Gene-Related Peptide as the Mediator of Beneficial Effects of Exercise in the Cardiovascular System
Authors: Skaria Tom , Vogel Johannes
Published: March 2022

Regular physical activity exerts cardiovascular protective effects in healthy individuals and those with chronic cardiovascular diseases. Exercise is accompanied by an increased plasma concentration of α-calcitonin gene-related peptide (αCGRP), a 37-amino acid peptide with vasodilatory effects and causative roles in migraine. Moreover, mouse models revealed that loss of αCGRP disrupts physiological adaptation of the cardiovascular system to exercise in normotension and aggravates cardiovascular impairment in primary chronic hypertension, both can be reversed by αCGRP administration. This suggests that αCGRP agonists could be a therapeutic option to mediate the cardiovascular protective effects of exercise in clinical setting where exercise is not possible or contraindicated. Of note, FDA has recently approved αCGRP antagonists for migraine prophylaxis therapy, however, the cardiovascular safety of long-term anti-CGRP therapy in individuals with cardiovascular diseases has yet to be established. Current evidence from preclinical models suggests that chronic αCGRP antagonism may abolish the cardiovascular protective effects of exercise in both normotension and chronic hypertension.
Comparative Transcriptome Analysis Reveals New Insight of Alfalfa (Medicago sativa L.) Cultivars in Response to Abrupt Freezing Stress
Authors: Wang Xia , Kang Wenjuan , Wu Fang , Miao Jiamin , Shi Shangli
Published: March 2022

Freezing stress is a major limiting environmental factor that affects the productivity and distribution of alfalfa (Medicago sativa L.). There is growing evidence that enhancing freezing tolerance through resistance-related genes is one of the most efficient methods for solving this problem, whereas little is known about the complex regulatory mechanism of freezing stress. Herein, we performed transcriptome profiling of the leaves from two genotypes of alfalfa, freezing tolerance “Gannong NO.3” and freezing-sensitive “WL326GZ” exposure to −10°C to investigate which resistance-related genes could improve the freezing tolerance. Our results showed that a total of 121,366 genes were identified, and there were 7,245 differentially expressed genes (DEGs) between the control and treated leaves. In particular, the DEGs in “Gannong NO.3” were mainly enriched in the metabolic pathways and biosynthesis of secondary metabolites, and most of the DEGs in “WL326GZ” were enriched in the metabolic pathways, the biosynthesis of secondary metabolites, and plant-pathogen interactions. Moreover, the weighted gene co-expression network analysis (WGCNA) showed that ATP-binding cassette (ABC) C subfamily genes were strongly impacted by freezing stress, indicating that ABCC8 and ABCC3 are critical to develop the freezing tolerance. Moreover, our data revealed that numerous Ca2+ signal transduction and CBF/DREB1 pathway-related genes were severely impacted by the freezing resistance, which is believed to alleviate the damage caused by freezing stress. Altogether, these findings contribute the comprehensive information to understand the molecular mechanism of alfalfa adaptation to freezing stress and further provide functional candidate genes that can adapt to abiotic stress.
Development of Mini-Barcode Based on Chloroplast Genome and Its Application in Metabarcoding Molecular Identification of Chinese Medicinal Material Radix Paeoniae Rubra (Chishao)
Authors: Yang Xia , Yu Xiaolei , Zhang Xiaoying , Guo Hua , Xing Zhimei , Xu Liuwei , Wang Jia , Shen Yuyan , Yu Jie , Lv Pengfei , Wang Yuefei , Liu Mengyang , Tian Xiaoxuan
Published: March 2022

Radix Paeoniae Rubra (Chishao), a typical multi-origin Chinese medicinal material, originates from the dried roots of Paeonia lactiflora or P. veitchii. The previous study suggested that these two commonly used Chishao showed variation in their chemical compositions and clinical efficacies. Therefore, accurate identification of different Chishao species was of great significance for the guide of clinical medication, and timely treatment of patients. In this study, the chloroplast genome sequences of P. lactiflora and P. veitchii were obtained by next-generation sequencing (NGS) technology, and then the hypervariable regions were selected to design two mini-barcode candidates for species identification. Combined with DNA metabarcoding technology, we performed qualitative and quantitative analysis on the artificially mixed samples of P. lactiflora and P. veitchii and evaluated the identification ability of these mini-barcode candidates. Furtherly, the mini-barcode with good performance was applied to distinguish the Chinese patent medicine “cerebral thrombosis tablets” containing Chishao. The results indicated that the chloroplast genomes of P. lactiflora and P. veitchii were 152,750 and 152,527 bp, respectively. As published previously, they exhibited a typical quadripartite structure including a large single-copy region (LSC), a small single-copy region (SSC) and a pair of inverted repeat regions (IRs). The nucleotide polymorphism analysis revealed seven variable protein-coding regions as petL, psaI, psbJ, rpl16, ycf1b, psaC, and ndhF, and two mini-barcodes were developed from ycf1b and ndhF respectively. The result suggested that both two mini-barcodes performed well distinguishing P. lactiflora from P. veitchii. Besides, P. lactiflora was the only raw material of Chishao in all collected “cerebral thrombosis tablets” samples. In general, this study has established a method to realize the qualitative and quantitative identification of Chishao as multi-origin Chinese medicinal materials, which can be applied to Chinese patent medicines containing Chishao.
A 4 bp InDel in the Promoter of Wheat Gene TaAFP-B Affecting Seed Dormancy Confirmed in Transgenic Rice
Authors: Feng Yumei , Han Yang , Han Bing , Zhao Yongying , Yang Yan , Xing Yanping
Published: March 2022

Background

Wheat (Triticum aestivum L.) ABA insensitive five (ABI5) binding protein gene (TaAFP) is a homologue of the ABI5 binding protein (AFP) gene in Arabidopsis thaliana. It is well documented that AtAFP is a negative regulator of ABA signaling that regulates embryo germination and seed dormancy. TaABI5 was earlier shown to be expressed specifically in seed and its transcript accumulated during wheat grain maturation and acquisition of dormancy. It plays an important role in seed dormancy. In a previous study, we identified two allelic variants TaAFP-B1a and TaAFP-B1b of TaAFP on chromosome arm 2BS in common wheat, designated as, respectively. Sequence analysis revealed a 4 bp insertion in the promoter of TaAFP-B1a compared with TaAFP-B1b that affected mRNA transcription level, mRNA stability, GUS and tdTomatoER translation level, and GUS activity determining seed dormancy.

Results

The transcription and translation levels of TaAFP-B were significantly reduced in TaAFP-Ba and TaAFP-Ba-GFP transgenic plants compared with TaAFP-Bb and TaAFP-Bb-GFP. The average GI (germination index) values of TaAFP-Ba and TaAFP-Ba-GFP were significantly lower than those of TaAFP-Bb and TaAFP-Bb-GFP in T1 and T2 transgenic rice seeds, whereas mature TaAFP-Ba and TaAFP-Ba-GFP transgenic seeds exhibited increased ABA sensitivity and content of endogenous ABA compared with TaAFP-Bb and TaAFP-Bb-GFP.

Conclusion

The 4 bp insertion in the promoter of TaAFP-Ba decreased transcript abundance and translation level in transgenic rice. This insertion increased sensitivity to ABA and content of endogenous ABA in mature seeds, leading to a higher seed dormancy and pre-harvest sprouting tolerance in transgenic rice.
Did Wheat Breeding Simultaneously Alter Grain Concentrations of Macro- and Micro-Nutrient Over the Past 80 Years of Cultivar Releasing in China?
Authors: Hao Baozhen , Ma Jingli , Si Luyao , Jiang Lina , Wang Xiaojie , Yao Chong , Ma Siyuan , Li Chunxi , Gao Zhiqiang , Wang Zhimin
Published: March 2022

Biofortification of wheat with mineral through crop breeding is a sustainable and cost-effective approach to address human mineral malnutrition. A better understanding of the trends of grain concentrations of mineral nutrients in wheat over the breeding period may help to assess the breeding progress to date. A 2-year field experiment using 138 Chinese wheat landraces and 154 cultivars was conducted. Grain concentrations of micronutrients (Cu and Mn) and macronutrients (N, P, and K) were measured and corrected for a yield level to elucidate the trends of these mineral nutrients over the 80 years of cultivar releasing and identify genetic variation for these mineral nutrients in cultivars and landraces. Large genetic variation exists for grain mineral nutrients concentrations among tested genotypes, indicating that selection for enhancing mineral nutrient concentrations in wheat is possible. Landraces showed a slightly wide genetic variation of grain Cu concentration and a much narrow variation of Mn concentration when compared to modern cultivars. Grain concentrations of Cu and Mn decreased slightly with increasing grain yield with a weak correlation, while N, P, and K concentrations declined obviously with increasing yield with a strong correlation, revealing that increased grain yield had a strong negative effect on grain concentration of macronutrients, but a relative weak negative effect on micronutrients concentrations. When considering the impact of the variation in yield on mineral concentrations, grain concentrations of Cu, Mn, N, P, and K in wheat cultivars released from 1933 to 2017 exhibited different trends with a year of variety release. Grain Cu, N, and P concentrations showed significant decreasing trends over a breeding period, while grain Mn and K concentrations showed no clear trend, suggesting wheat breeding in China over the past 80 years has decreased grain concentrations of Cu, N, and P, and did not alter Mn and K concentrations. Finally, a total of 14 outstanding accessions with high grain mineral nutrients concentrations/contents were identified, and these genotypes can be considered as promising donors for developing mineral-dense wheat cultivars.
From Micro to Macro: The Combination of Consciousness
Authors: Young Asa , Robbins Isabella , Shelat Shivang
Published: March 2022

Crick and Koch’s 1990 “neurobiological theory of consciousness” sparked the race for the physical correlates of subjective experience. 30 years later, cognitive sciences trend toward consideration of the brain’s electromagnetic field as the primary seat of consciousness, the “to be” of the individual. Recent advancements in laboratory tools have preceded an influx of studies reporting a synchronization between the neuronally generated EM fields of interacting individuals. An embodied and enactive neuroscientific approach has gained traction in the wake of these findings wherein consciousness and cognition are theorized to be regulated and distributed beyond the individual. We approach this frontier to extend the implications of person-to-person synchrony to propose a process of combination whereby coupled individual agents merge into a hierarchical cognitive system to which they are subsidiary. Such is to say, the complex mammalian consciousness humans possess may not be the tip of the iceberg, but another step in a succeeding staircase. To this end, the axioms and conjectures of General Resonance Theory are utilized to describe this phenomenon of interpersonal resonant combination. Our proposal describes a coupled system of spatially distributed EM fields that are synchronized through recurrent, entraining behavioral interactions. The system, having achieved sufficient synchronization, enjoys an optimization of information flow that alters the conscious states of its merging agents and enhances group performance capabilities. In the race for the neurobiological correlates of subjective experience, we attempt the first steps in the journey toward defining the physical basis of “group consciousness.” The establishment of a concrete account of the combination of consciousness at a scale superseding individual human consciousness remains speculation, but our suggested approach provides a framework for empirical testing of these possibilities.
Lexical Orthographic Knowledge Mediates the Relationship Between Character Reading and Reading Comprehension Among Learners With Chinese as a Second Language
Authors: Liao Xian , Loh Elizabeth Ka Yee , Cai Mingjia
Published: March 2022

Reading in Chinese is complex because readers should not only recognize characters by basic units (i.e., characters) but also integrate characters into words when reading text. While many efforts have been devoted to investigating the effect of sub-lexical orthographic knowledge in Chinese character reading, less is known about the role played by lexical orthographic knowledge at word level. A total of 424 secondary learners with Chinese as a second language (CSL) in Hong Kong were assessed with character reading, reading comprehension, and two lexical orthographic knowledge tasks: lexical orthographic choice (OKC) and lexical orthographic choice in context (OKCC). Path analysis results demonstrated that these lexical orthographic skills significantly mediated the effect of character reading on comprehension, in which OKCC was a more critical mediator as its mediating effect was bigger than that of OKC. Further analyses showed that these mediating effects were significant only among students with richer learning experience (i.e., learning Chinese for 4 years or above). Our results illustrate the possible trajectory of CSL learners’ literacy development from character reading to reading comprehension and provide pedagogical implications for teaching and learning.
Adaptations in Visual Search Behaviour as a Function of Expertise in Rugby Union Players Completing Attacking Scenarios
Authors: van Paridon Kjell N. , Lally J. , Robertson P. J. , Basevitch Itay , Timmis Matthew A.
Published: March 2022

The current study investigated the adaptations which occur in visual search behaviour as a function of expertise in rugby union players when completing attacking scenarios. Ten experienced players (EP) and ten novice players (NP) completed 2 vs. 1 attacking game scenarios. Starting with the ball in hand and wearing a mobile eye tracker throughout, participants were required to score a try against a defender. The scenarios allowed for a pass to their supporting player (Spin Pass or Switch) or trying to run past the defender (Take-Player-On or Dummy Switch). No between group differences were found in fixating on the supporting attacking player (p > 0.05). However, EP increased the length (p = 0.008) and frequency (p = 0.004) looking at the area immediately ahead of the supporting player, particularly when executing a spin pass. NP fixated longer (p = 0.005) and more frequently (p = 0.032) at the defender, whilst EP fixated more frequently in the space the supporting player would run into in Switch and Dummy Switch scenarios (p = 0.025). More successful passes were completed and tries scored by EP compared to NP (p = 0.001). Differences in visual search behaviour between experienced and NP suggest that the experts extract information from areas directly related to guiding the motor action; the space immediately ahead of the support player to pass the ball in. Contrastingly, novices use a more allocentric perspective where the actions from the defender are used to guide their motor actions.
Effect of Serendipity in an Encounter on Purchase Intention of Unexpected Products
Authors: Liang Shichang , Chu Yuxuan , Zhang Min , Li Rulan , Lan Bin , He Lingling
Published: March 2022

Previous studies on the follow-up effect of serendipity mostly focused on the positive effects and less on the negative effects. Therefore, the purpose of this article is to investigate the negative effect of serendipity on the purchase intention of unexpected products. To verify all hypotheses in this article, we used online and offline survey data in China. Three experimental results showed that serendipity contains a certain degree of uncertainty, which will cause consumers’ perceived risk and decrease the purchase intention of unexpected products. Perceived risk plays a mediating role in the effect of serendipity on the purchase intention of unexpected products. Moreover, regulatory focus moderates the effect of serendipity on purchase intention of unexpected products. Specifically, for prevention-focused individuals, the negative effect of serendipity on the purchase intention of unexpected products is strengthened. For promotion-focused individuals, the negative effect of serendipity on the purchase intention of unexpected products is weakened. This article augments the understanding of the negative effects of serendipity and provides theoretical guidance and support for the management practice of marketers.
Prediction Models for Radiation-Induced Neurocognitive Decline in Adult Patients With Primary or Secondary Brain Tumors: A Systematic Review
Authors: Tohidinezhad Fariba , Di Perri Dario , Zegers Catharina M. L. , Dijkstra Jeanette , Anten Monique , Dekker Andre , Van Elmpt Wouter , Eekers Daniëlle B. P. , Traverso Alberto
Published: March 2022

Purpose

Although an increasing body of literature suggests a relationship between brain irradiation and deterioration of neurocognitive function, it remains as the standard therapeutic and prophylactic modality in patients with brain tumors. This review was aimed to abstract and evaluate the prediction models for radiation-induced neurocognitive decline in patients with primary or secondary brain tumors.

Methods

MEDLINE was searched on October 31, 2021 for publications containing relevant truncation and MeSH terms related to “radiotherapy,” “brain,” “prediction model,” and “neurocognitive impairments.” Risk of bias was assessed using the Prediction model Risk Of Bias ASsessment Tool.

Results

Of 3,580 studies reviewed, 23 prediction models were identified. Age, tumor location, education level, baseline neurocognitive score, and radiation dose to the hippocampus were the most common predictors in the models. The Hopkins verbal learning (n = 7) and the trail making tests (n = 4) were the most frequent outcome assessment tools. All studies used regression (n = 14 linear, n = 8 logistic, and n = 4 Cox) as machine learning method. All models were judged to have a high risk of bias mainly due to issues in the analysis.

Conclusion

Existing models have limited quality and are at high risk of bias. Following recommendations are outlined in this review to improve future models: developing cognitive assessment instruments taking into account the peculiar traits of the different brain tumors and radiation modalities; adherence to model development and validation guidelines; careful choice of candidate predictors according to the literature and domain expert consensus; and considering radiation dose to brain substructures as they can provide important information on specific neurocognitive impairments.
There’s No Sport Without Spectators – Viewing Football Games Without Spectators During the COVID-19 Pandemic
Authors: Tamir Ilan
Published: March 2022

The presence of sports fans in the stands is considered a natural and essential element of sporting events. Beyond the atmosphere fans create and the color they add to the game, their presence reflects the idea that the game is more than a competition between two teams —it is a grand battle between communities and identities, which is also the reason that fans are willing to sacrifice so much on behalf of their team. As is other areas of life, the COVID-19 pandemic created an unusual situation, in which sporting events were held without spectators in the stadium stands. In many places around the world, professional sporting activities were permitted but spectators were not allowed into the stadiums due to social distancing restrictions. The current study examines this unique situation and through it, gains an understanding of fans’ beliefs concerning the significance of spectators and their presence in the stadium. Through in-depth interviews with football fans who regularly attend games (in the pre-pandemic period), the current study explores football fans’ experiences as they viewed “ghost games” (where teams played to empty stadiums). Findings show that this unique situation, caused by the global pandemic, heightened fans’ deep-rooted connection to sports and to their favorite team, and also exacerbated the social, emotional, and professional implications of viewing football games with no spectators.
Identifying the Leadership Challenges of K-12 Public Schools During COVID-19 Disruption: A Systematic Literature Review
Authors: Parveen Khalida , Tran Phuc Quang Bao , Alghamdi Abdulelah A. , Namaziandost Ehsan , Aslam Sarfraz , Xiaowei Tian
Published: March 2022

Globally, the COVID-19 pandemic is triggering a public health emergency and crisis on a large scale, with far-reaching effects and severe damage to all aspects of politics, economy, cultural and social life, and health. Consecutive outbreaks over the past nearly 2 years of “living with COVID-19” have forced most schools to physically close, resulting in the largest educational disruption in human history. In turbulent times of the COVID-19 crisis, school leaders are facing numerous major challenges germane to school governance and leadership. The key objective of the study is to fully explore the prospective challenges principals are encountering in public schools in times of COVID-19. To fulfill the research purpose, a systematic literature review (SLR) was carried out to investigate the leadership challenges. As a result, a total of 24 challenges were explored through SLR approach. Frequency analysis approach was initially applied to figure out the most significant challenges. Accordingly, seven challenges were found statistically significant as showing frequency ≥ 50 each. Irrevocably, the study works as a contribution to K-12 school leadership by providing guidance for current and future leaders in crisis based on practical investigation, experiences, and recommendations. Policy makers can leverage these findings to make necessary adjustments to school policy to better prepare school leaders for crisis. Additionally, the findings of the current study are believed to have profound implications for future research. These findings expand our current understanding on school leadership in time of crisis that needs further investigation. Subsequent studies can quantitatively and/or qualitatively validate these leadership challenges findings regarding a particular school context.
A Qualitative Study on Sexuality and Sexual Experiences in Community Forensic Mental Health Patients in Queensland, Australia
Authors: Brand Elnike , Nagaraj Dinesh , Ratsch Angela , Heffernan Edward
Published: March 2022

This qualitative study reports on the sexuality and sexual experiences of community-based forensic mental health participants. The findings indicate that these participants feel the need for intimacy and want to engage in sexual activity more often than their neurotypical Australian peers. Participants identified their mental health and the side effects of compliance with prescribed psychotropic medications were barriers to achieving their desired level of sexual activity. Participants supported the notion that mental health teams were positioned to assist patients navigate the psychological, cultural, education and physical barriers to achieving sexual health and wellbeing. We propose several interventions to support these participants and other community forensic mental health patients in attaining healthy relationships, understanding their sexual health, and gaining more fulfilling sexual experiences. These interventions, which include sex education, upskilling in socialization and communication, and regular medication reviews, could be delivered as part of the holistic care provided by mental health teams. Mental health clinicians should be offered appropriate training to assess patients and have discussions related to sexuality, sexual experiences and sexual health needs.
Association Between Sulfur Dioxide and Daily Inpatient Visits With Respiratory Diseases in Ganzhou, China: A Time Series Study Based on Hospital Data
Authors: Zhou Xingye , Gao Yanfang , Wang Dongming , Chen Weihong , Zhang Xiaokang
Published: March 2022

Background

Sulfur dioxide (SO2) has been reported to be related to the mortality of respiratory diseases, but the relationship between SO2 and hospital inpatient visits with respiratory diseases and the potential impact of different seasons on this relationship is still unclear.

Methods

The daily average concentrations of air pollutants, including SO2 and meteorological data in Ganzhou, China, from 2017 to 2019 were collected. The data on daily hospitalization for respiratory diseases from the biggest hospital in the city were extracted. The generalized additive models (GAM) and the distributed lag non-linear model (DLNM) were employed to evaluate the association between ambient SO2 and daily inpatient visits for respiratory diseases. Stratified analyses by gender, age, and season were performed to find their potential effects on this association.

Results

There is a positive exposure-response relationship between SO2 concentration and relative risk of respiratory inpatient visits. Every 10 μg/m3 increase in SO2 was related to a 3.2% (95% CI: 0.6–6.7%) exaltation in daily respiratory inpatient visits at lag3. In addition, SO2 had a stronger association with respiratory inpatient visits in women, older adults (≥65 years), and warmer season (May-Oct) subgroups. The relationship between SO2 and inpatient visits for respiratory diseases was robust after adjusting for other air pollutants, including PM10, NO2, O3, and CO.

Conclusion

This time-series study showed that there is a positive association between short-term SO2 exposure and daily respiratory inpatient visits. These results are important for local administrators to formulate environmental public health policies.
Associations of Humidity and Temperature With Cataracts Among Older Adults in China
Authors: Lv Xiaoyang , Gao Xiangyang , Hu Kejia , Yao Yao , Zeng Yi , Chen Huashuai
Published: March 2022

Background

The burden of cataracts was substantial in the current aging world. However, few epidemiological studies have examined the associations between climate and weather conditions and cataract in older populations. We aimed to investigate the associations of air relative humidity and temperature with cataracts in older adults in China.

Methods

We used the cohort data from 2002, 2005, 2008, 2011, 2014, and 2018 waves of the Chinese Longitudinal Healthy Longevity Survey (CLHLS). A total of 62,595 Chinese older adults aged between 65 and 105 years were included in the analyses. City-level annual average air humidity and temperature during 2001 and 2017 (before the survey year) was used to measure population exposure. A cataract was self-reports based on the medical record or the doctor's diagnosis and 8,071 older adults had cataract. Covariates included socio-demographic, health status, lifestyles, and chronic conditions. We adopted the Generalized estimation equation (GEE) model to analyze the associations of relative humidity and temperature with cataracts.

Results

We found that the average relative humidity (OR: 0.99; 95% CI: 0.98–0.99) in the past year was inversely associated with cataract likelihoods in older adults and a positive association between temperature (OR: 1.04; 95%CI: 1.03,1.05) in the past year and cataract likelihoods in older adults. The associations were robust in stratified analyses by sex, urban/rural residence, and education level. Furthermore, we found a nonlinear J-shaped relationship between temperature and cataract prevalence.

Conclusion

Our findings provide the evidence that higher temperature and low relative humidity may be associated with cataracts in older adults.
Integrated Design and Optimization of Water-Energy Nexus: Combining Wastewater Treatment and Energy System
Authors: Rezazadeh Kalehbasti Pouya , Lepech Michael D. , Criddle Craig S.
Published: March 2022

Designing more sustainable urban infrastructure is an essential topic in practice and research. While many have tried to address this challenge by focusing on sustainability of either supply or demand in a single infrastructure system, few studies have integrated the decisions for both supply and demand across several infrastructure. This paper proposes a novel method to design and optimize the hourly demand and supply of integrated energy and water system in an urban district for environmental and economic sustainability. This modular framework concurrently designs the optimal building mix of an urban district and the systems supplying the district with wastewater treatment, cooling, heating, and electricity. The model is tested on a sample neighborhood from San Francisco, California, with 21 building prototypes, 32 combined heating and power engines, 16 chillers, and 3 wastewater treatment systems (a central treatment plant and two decentralized membrane-based systems). The results of this study show that the median values of normalized life-cycle cost, social cost of carbon, annual energy demand, and annual wastewater production of the integrated designs of water-energy system are, respectively, 20, 75, 8, and 20% lower than those of the traditional segregated designs. The results also demonstrate the economic and environmental viability of using decentralized advanced treatment in urban areas when energy system, wastewater treatment, and building mix are designed together.
Why Are We so Scent-Imental? Studying Odor-Linked Memories
Authors: Thomas Angela-Faith , Papesh Megan H.
Published: March 2022

Memories that are brought on by smells are called odor-linked memories. Odor-linked memories have a large impact on our lives. When these memories are positive, our physical well-being and emotional and mental states improve. Although we often look at pictures to remember the past, odors are actually better at helping us remember. Brain scans show that odors bring on strong memories because of the brain regions that process them. The group of brain areas that are best known for processing emotions, learning, and memory also process odors. When you smell something, to process the smell, your brain uses the same areas that it would use to process emotions and memories. This makes smells great at helping us remember emotional memories! Understanding the effects of odor-linked memories can help us use them to positively affect our daily lives, in both the short-term and the long-term.
Nerves, Pain and Consciousness
Authors: Baron Mark , Minert Anne , Yatziv Shai-lee , Devor Marshall
Published: March 2022

We all experience pain at one time or another. Pain is an essential “alarm bell” that tells us that something is wrong, and a “teacher” that reminds us not to do that same thing again. Usually, pain is felt when a stimulus, such as a pinch or an injury, causes electrical pulses to run along one of the cables of nerve fibers in our body and into the brain where they generate an unpleasant sensory and emotional experience. Sometimes pain occurs without any actual stimulus, such as when nerve fibers have been damaged. An example is the phantom pain that amputees sometimes feel in their missing limb. Certain drugs can stop pain by blocking the electrical pulses before they reach the brain. Other drugs stop pain in a different way, by preventing the brain from reading the pain message carried by the electrical pulses. This article explains what happens in the body when we are hurt, how the brain causes this to be felt as pain and how certain drugs can stop pain.
Biomechanics of the Hammer Throw: Narrative Review
Authors: Castaldi Gian Mario , Borzuola Riccardo , Camomilla Valentina , Bergamini Elena , Vannozzi Giuseppe , Macaluso Andrea
Published: March 2022

Hammer throw is a discipline characterized by unique biomechanical features, which have often captured the interest of scientists and coaches in athletics. However, most studies have been published on technical journals for coaches and there are only few works on the biomechanical aspects of hammer throw in scientific literature. This narrative review provides a critical evaluation of the articles published in scientific and the most relevant technical journals with a particular focus on the biomechanical aspects that underlie the throwing technique and contribute to performance enhancement. The modern throwing technique has many elements in common with that used by the best throwers in the Eighties, underlying a limited development in the biomechanical understanding of throwing motion in recent years. This review analyses the ballistic and environmental aspects of the discipline as well as the motion of the center of mass of both the hammer and thrower. Furthermore, the orbital movement of the hammer and the forces involved in the throw are evaluated. This review emphasizes the kinematic and dynamic parameters that emerge as the most relevant to improve the throwing performance. Among these, linear release velocity appears to be a fundamental element. To maximize this variable, the athlete is required to accelerate the hammer by applying force. The curve of the time-tangential velocity of the hammer follows a trajectory very similar to that of the forces applied to the hammer-thrower system indicating a strong relationship between the two variables. The thrower uses the action of the leg muscles to gain momentum, which is then transferred to the hammer through the trunk and arm muscles, thus obtaining an increase of the linear release velocity. This review provides coaches with a critical analysis of the hammer throw technique, highlighting relevant factors for future development of training programmes. Our work reveals a substantial gap in the literature, particularly concerning the evaluation of fundamental key aspects of the throw such as the assessment of preliminary winds, the entry to the first turn and the definition of the rotation axes involved in the throw. A more in-depth analysis of these key elements is required to improve the understanding of the biomechanics of hammer throw.
Integrating Social-Ecological and Political-Ecological Models of Agrobiodiversity With Nutrient Management of Keystone Food Spaces to Support SDG 2
Authors: Zimmerer Karl S. , Jones Andrew D. , de Haan Stef , Creed-Kanashiro Hilary , Tubbeh Ramzi M. , Hultquist Carolynne , Tello Villavicencio Milka N. , Plasencia Amaya Franklin , Nguyen Kien Tri
Published: March 2022

Agrobiodiversity—the biodiversity of food, agriculture, and land use—is essential to U.N. Sustainable Development Goal 2 by providing crucial food and nutritional quality of diets combined with strengthening agroecological sustainability. Focusing on the agrobiodiversity nexus to SDG 2, the current study utilized the interdisciplinary Agrobiodiversity Knowledge Framework (AKF), household-level surveys, and biodiversity sampling of crop fields and home gardens in a case study in Huánuco, Peru, in 2017. Statistical measures estimated agrobiodiversity of crop fields (n= 268 households) and home gardens (n=159 households) based on species richness (3.7 and 10.2 species/household, in fields and gardens, respectively) and evenness (Shannon diversity index; 0.70 and 1.83 in fields and gardens, respectively). Robust results of Poisson and OLS regression models identified several AKF-guided determinants of agrobiodiversity. Estimated species richness and evenness were significantly associated with 12 social-ecological and political-ecological factors from the four AKF thematic axes: farm characteristics and agroecology; diets and nutrition; markets, governance and sociocultural practices; and global change. This study's AKF approach, agrobiodiversity modeling, agroecological characterization, and field-based case study advanced a series of useful research insights, comparisons, and conceptual innovations to address SDG 2. Characterization of nutrient management through soil- and plant-focused cultural practices and livelihood roles distinguished the “keystone agrobiodiversity-and-food space” of multi-species maize fields (maizales) identified in AKF regression and characterization results. This key space furnished crucial food-nutrition and agroecological benefits that can be expanded by overcoming identified barriers. AKF-guided models incorporating key agrobiodiversity-and-food spaces and ecological nutrient management are needed to strengthen SDG 2 strategies.