bluuebunny/crossref_metadata_2025 huggingface dataset:
Drug provision model of patients based on an architectural approach in the context of digital transformation of military healthcare
Authors: Miroshnichenko Yury V. , Shcherba Maria P. , Merkulov Andrey V. , Davydova Maria V.
Published: October 2023

According to architectural modeling (the architectural structure of an open group), typed blocks of elements forming the basic components or layers of the architecture of a military medical organization are considered, combined into six domains with a schematic representation as typical architecture. The rational allocation of layers, their contents, interrelations, and directions of development provide an opportunity to effectively manage the complex multidisciplinary military medical organization during digital transformation. For the introduction and implementation of digital solutions, the analysis of the creation of an integrated module of a single digital contour for managing medical property resources indicates the feasibility of substantiating and developing reference functional models according to a single standard for describing business processes and the need to choose the most optimal methodology and notation for modeling reference functional architectures of a military medical organization. In a comparative analysis of the selected notations according to reasonable criteria, the business process model and designations were determined as the optimal and universal description language that most fully meets the needs of functional modeling of the architecture of information systems for the subsequent automation and digitalization of the management of medical property resources in a military medical organization. The reference functional model of the information system for the management of medical property resources is presented by the description of the processes of drug provision of admitted patients, which is one of the main target areas of the military medical organization considering its state task. Moreover, a well-founded and developed standard functional architecture in the notation of the business process model and notation 2.0 is presented as interacting pools displaying the subjects (participants) of the process with the tasks assigned to them. The methods and methodological approaches presented in the article, as well as models of functional architectures for providing medicines to patients admitted to a military medical organization, can be used as a reference in the digital transformation of the management of medical property resources at various levels of military healthcare.
Fungal Keratitis. Part 1. Etiomorphology, Historical Aspects, Epidemiology, Risk Factors, Pathogenesis and Clinical Features
Authors: Shilovskikh O. V. , Ponomarev V. O. , Timofeev V. L.
Published: October 2023

Fungal keratitis (FK) is 8–30 % in the structure of infectious inflammation of the cornea. There are 2 main types of mushroom growth — mycelial and yeast. Mycelial (mold) fungi grow in the form of special branched microscopic tubes — hyphae. Yeast fungi form compact colonies of individual oval cells. Due to the peculiarities of the yeast structure, the tendency to rapid spread in the tissues is reduced, which determines the less aggressive clinical course of such keratomycosis compared to mold. Until the 50s of the 20th century, the occurrence of FK in the world was low. However, probably with the introduction of corticosteroid and antibacterial drugs into medicine, their prevalence began to grow. The highest frequency of occurrence of FK is in regions with a hot climate and high involvement of the population in agriculture. The main provoking factor for the appearance of FK is corneal injury with damage to the epithelium and adhesion to the Bowman’s membrane or stroma components. Highly adhesive fungi (Aspergillus spp., Candida spp.) trigger a cascade of immune inflammatory reactions, production of reactive oxygen species and matrix metalloproteases-9, which leads to the destruction of lamellae. Fungi with low adhesive ability (Fusarium spp.) can grow parallel to lamellae for a long time and indefinitely without inducing pronounced inflammation. Symptoms of FC are similar to those observed in other forms of infectious keratitis, but more often they develop more slowly (5–10 days) and are less acute. A defect against the background of mycelial FC is more often characterized by jagged edges, a raised slough, and a non-yellow color. Yeast FK is manifested by oval ulceration of the epithelium with expanding, more sharply demarcated, densely focal suppuration.
Evaluation of Corneal Topography Changes Following Deep Anterior Lamellar Keratoplasty in Patients with Keratoconus
Authors: Neslihan S. , Ümit Ç. , Ferhat E. , Selim G.
Published: October 2023

Background. The aim of this study is to evaluate the morphologic changes of the cornea and anterior chamber by using corneal topography (CT) in patients undergoing deep anterior lamellar keratoplasty (DALK) due to keratoconus. Patients and methods. This observational case-control study included total 53 eyes of 53 patients with keratoconus and underwent DALK surgery. All patients were evaluated preoperatively and 3 months after suture removal with CT. In CT, anterior chamber depth (ACD), iridocorneal angle (ICA), anterior chamber volume (ACV), central corneal thickness (CCT), maximum keratometric value (Kmax), flattest simulated meridian keratometry (SimK1), steepest simulated meridian keratometry (SimK2) and simulated keratometry average (SimKavg) results were compared before and after DALK surgery. Results. A significant increase was observed in CCT values after DALK surgery (p < 0.001). Patients showed statistically significant decrease in Kmax, SimK1, SimK2 and SimKavg values (p < 0.001 for all). Postoperative ACD and ACV values were significantly lower (p < 0.001). The ICA values showed no significant difference (p = 0.183) between preoperative and postoperative values (49,95 ± 5,85 and 46,30 ± 11,33 respectively). Conclusion. We determined a dramatic decrease in keratometric values, ACD and ACV values and an increase of corneal thickness after DALK surgery. Although DALK can be performed without interfering with the anterior chamber, has a significant effect in anterior chamber.
The Precision of Calculating the Optical Power of the IOL in Various Methods of Out-Bag IOL Fixation
Authors: Yusef Yu. N. , Vvedenskiy A. S. , Ivanov M. N. , Alkharki L. , Fokina N. D.
Published: October 2023

The calculation of the optical power of the IOl for out-bag implantation remains one of the actual problems of cataract surgery. Purpose. Comparative study of the precision of calculating the optical power of the IOL for retropupillary fixation of an iris-claw lens, transscleral fixation of a rigid IOL with two flexible haptic elements and transscleral fixation of an soft hydrophobic IOL with two open haptic elements. Patients and methods. The study included 105 patients (108 eyes) with complicated phacoemulsification in combination with lens subluxation. First group included 39 patients (42 eyes) with complicated phacoemulsification and retropupillary implantation of an iris-claw lens. Second group included 29 patients (29 eyes) with complicated phacoemulsification and transscleral suture fixation of rigid PMMA IOL. Third group included 37 patients (37 eyes) with complicated phacoemulsification and transscleral suture fixation of an soft hydrophobic IOL with two open haptic elements. In the postoperative period we performed a comparative evaluation of visual acuity without correction and best corrected visual acuity, IOL optical power calculation precision within ±0.5 diopters, the average absolute error of IOL optical power calculation. Results. Three months after the operation the visual acuity of 0.8–1.0 without correction was obtained in 35,7 % of cases in the 1st group, 17.2 % in the 2nd group, 16.2 % in the 3rd group. The precision of postoperative refraction within ±0.5 diopters was 95.2 % in the 1st group, 86.2 % in the 2nd group 83.7 % in the 3rd group. The average absolute error of IOL optical power calculation was 0.33 ± 0.07 diopters in the 1st group, 0.57 ± 0.18 diopters in the 2nd group, 0.62 ± 0.19 diopters in the 3rd group (р < 0.05). Three months after surgery there were no significant differences in best corrected visual acuity and the degree of induced astigmatism. Conclusion. Retropupillary implantation of an iris-claw lens during complicated phacoemulsification significantly increases visual acuity without correction, frequency calculation precision within ±0.5 diopters, significantly reduces the average absolute calculation error compared to transscleral suture fixation of the IOL.
Comprehensive Classification of the Severity of Bulbar and Tarsal Hyperemia in Conjunctivitis
Authors: Trubilin V. N. , Polunina E. G. , Kozhukhov A. A. , Andzhelova D. V. , Trubilin A. V. , Chinenova K. V. , Moreva N. V.
Published: October 2023

Diagnosis of conjunctivitis is an urgent problem in ophthalmic practice, since conjunctivitis is one of the most common reasons for patients to visit a doctor. An important aspect in diagnosing of the conjunctivа’s inflammation is to determine the intensity of the inflammatory process in each case, in which hyperemia is given priority, as the most demonstrative sign of inflammation. Currently, there are many subjective and non-invasive instrumental methods for assessing conjunctival hyperemia. Taking into account the fact that most of the instrumental methods are aimed to assess the state of the bulbar conjunctiva and there are practically no methods that allow assessing the severity of tarsal hyperemia, it is necessary to develop a methodology that allows to evaluate both these indicators in combination. In this regard, it is great interest to determine the degree of hyperemia during a biomicroscopic examination in combination with visualization and fixation of hyperemia indicators using the software of the MediWorks Dixion S 350 slit lamp (weak, medium, significant, severe) depending on the index of hyperemia obtained by fixing the image on the slit lamp. Standardization of the severity indicators of conjunctival hyperemia allows to obtaine objective data on the state of the tarsal and bulbar conjunctiva at all stages of observation. In addition, based on the above indicators in clinical practice, the ophthalmologist can prescribe an adequate amount of drug therapy, this will increase the level of safety and effectiveness of the therapy, which is especially important at the stage of primary outpatient admission, when treatment is usually prescribed empirically
Study of Frequency and Nosology of Clinical Varieties of Retinal Dystrophies in Children and Adolescents
Authors: Kolenko O. V. , Sorokin E. L. , Sergeeva A. V.
Published: October 2023

Background. Particular vigilance in timely detection of retinal dystrophies (RD) in children is necessary as effective measure to prevent formation of rhegmatogenous retinal detachment. Purpose. To study frequency and structure of clinical forms of RD in children of different age groups to find out most typical age of their primary formation, to assess the proportion of their prognostically hazardous forms. Materials and methods. Clinical material — 314 children aged 5 to 17 years, on average 11.0 ± 0.6 years, who applied with various ophthalmological pathologies in the Department of Pediatric Ophthalmology of the Khabarovsk Branch of the S. Fyodorov Eye Microsurgery Federal State Institution in the period from July 2020 to April 2021. All children underwent biomicroscopy, ophthalmoscopy with in-depth examination of the state of the equatorial and periphery parts of the retina in condition of maximum cycloplegia. All 4 quadrants of the fundus were examined using binocular indirect ophthalmoscope with 20D lens. The presence and frequency of RD, their clinical varieties, according to the classification of E.O. Saksonova (1979), were ascertained in each of the studied age groups. Their localization, their length, and eye refraction were also assessed. Results. Presence of RD was revealed in 34 (11 %) children. In structure of identified clinical forms of RD, 11 children had its prognostically non-hazardous forms of RD, 23 children had prognostically hazardous forms (33 % and 67 % respectively). According to our data, the earliest age of detection of RD was 6 years. Further progression of RD was noted in 2 out of 6 children after restrictive photocoagulation of prognostically hazardous forms of RD. Conclusion. Formation of RD occurs not only at puberty, but also at an earlier age, according to our data, from 6 years of age. In view of this, it is necessary to conduct a thorough ophthalmoscopic examination of the periphery parts of the retina, even in young children.
Evaluation of the Impact of Mid-Infrared Laser Radiation on Eye Tissues (Experimental Study)
Authors: Yusef Yu. N. , Petrachkov D. V. , Korobov E. N. , Novikov I. A. , Kravchik M. V.
Published: October 2023

Purpose — to study the effect of a mid-infrared laser with a wavelength of 3.0 μm on the eye tissue. Materials and methods. An experimental laser device “Laser scalpel in the middle infrared range 2–8 μm for precision surgery” was used. The range of the radiation spectrum generated by this laser coincides with the spectral absorption peaks of such biological tissue chromophores as water, proteins and cholesterol esters, which makes it possible to use this laser in precision surgery (ophthalmology, neurosurgery, vascular surgery). In this study, we chose a wavelength of 3 µm, which coincides with the peak of the spectral absorption of water. The retina, choroid, sclera of porcine and cadaveric eyes was used as biological tissue. The effect of laser radiation on tissue was carried out in air. The application of coagulates was performed in different modes: 1) single pulses, 2) continuous mode. The impact of laser radiation on eye tissues was assessed using a scanning electron microscope. Results. When exposed to a single laser pulse with an energy of even 1 mJ, a through defect of the retina was observed. When exposed to a single laser pulse on the choroid with an energy of 1 to 3 mJ, the depth of the crater was 110–130 µm, the width of the crater was 97–122 µm, and the zone of collateral damage was 22–28 µm. When exposed to a single laser pulse on the sclera with an energy of 1 to 3 mJ, the depth of the crater was 170–201 µm, the width of the crater was 260–303 µm, and the zone of collateral damage was 57–72 µm. With continuous exposure to laser radiation on the choroid and sclera, the depth, width of the coagulate, the zone of collateral damage with similar laser parameters were greater than with a single pulse. Conclusion. Using this laser at a wavelength of 3 μm, it is possible to dissect eye tissues, which can be useful in vitreoretinal surgery for retinotomy, cutting out the choroid-pigment epithelium complex, and in antiglaucoma surgery for non-penetrating deep sclerectomy. However, further research is needed to optimize such laser parameters as the number of pulses in a packet, pulse duration, and pulse energy.
Differential Diagnostic Indicators for the Appointment of Non-Steroidal Anti-Inflammatory Therapy in the Treatment of Red Eye Syndrome at the Stage of Primary Outpatient Admission. Part 2
Authors: Trubilin V. N. , Polunina E. G. , Kozhukhov A. A. , Kurenkov V. V. , Moreva N. V. , Trubilin A. V. , Chinenova K. V.
Published: October 2023

In recent years, the Delphi method (DMt) has been widely used in scientific practice. It is based on an expert assessment of the object under study, which is formed on the basis of a survey of a group of experts in a particular field. The application of the Delphi method in various areas of ophthalmological practice has made it possible to develop practical recommendations for the diagnosis of visual stress, methods for diagnosing and treating keratoconus, to develop clinical guidelines for the diagnosis and treatment of patients with Sjögren’s syndrome, to classify the signs and symptoms of dry eye syndrome in accordance with the main mechanism of its occurrence and etc. A survey ophthalmologist expert conducted during the study, performed in accordance with the Delphi method, aimed at developing a differential algorithm in the treatment of patients with one of the most common pathologies among diseases belonging to the category of “red eye syndrome” — conjunctivitis, allowed identify key symptoms for prescribing different groups of drugs. In accordance with the clinical guidelines developed by the Russian Association of Ophthalmologists, the following groups of drugs are recommended for use: antibacterial, antiseptic, antihistamine, non-steroidal anti-inflammatory drugs, steroidal anti-inflammatory drugs, antiviral drugs. This article presents the results obtained in determining the indications for the use of non-steroidal anti-inflammatory therapy in the treatment of conjunctivitis. These include: the presence of a history of systemic diseases, the duration of inflammation for more than 7 days, the absence or presence of mucous discharge, complaints of a feeling of pain, discomfort in the eyes, their redness, as well as biomicroscopic signs of inflammation, which manifest themselves as mild to moderate conjunctival hyperemia expressiveness. The result obtained is of fundamental practical importance for primary outpatient ophthalmologists for choosing rational drug therapy in the treatment of one of the most common pathologies encountered in ophthalmic practice — conjunctivitis. A differentiated approach in choosing the volume and type of drug therapy based on the severity of the inflammatory process will reduce the drug load on the ocular surface. In accordance to the data presented in the first part of this article, it will lead to a decrease the risk of developing signs of dry eye syndrome against the background of a stopped inflammatory process in the long-term period and improving the quality of life in patients.
Clinical Manifestations and Mechanisms of Development of Eye Damage in Hemoblastosis
Authors: Yusef N. Yu. , Misyurina E. N. , Andzhelova D. V. , Kazaryan E. E. , Vorobyeva M. V.
Published: October 2023

In the article various ophthalmic manifestations of hemoblastoses will be discussed. Detailed descriptions of the most common variants of damage to the organ of vision in the oncohematological process are presented. Here we also present the clinical symptoms and development mechanisms associated with both direct leukocyte infiltration of various structures of the eye, occurring against the background of the underlying disease, and concomitant conditions, such as violation of the hemostasis system, anemia and thrombocytopenia resulting from the progression of blood cancer. It is also considered the cases of ophthalmic manifestations of hemoblastoses developing against the background of an immunity decrease associated oncohematological disorder, or as a result of the toxic effect of chemotherapy drugs, radiotherapy and bone marrow transplantation, as well as targeted therapy.
New Possibilities for Hyposecretory Dry Eye Treatment
Authors: Yanchenko S. V. , Malyshev A. V. , Odilova G. R. , Petrosyan L. M. , Odilov M. Yu.
Published: October 2023

Purpose: to evaluate the effectiveness of a fixed combination of 0.24 % hyaluronic acid, carbomer, glycerol and a lipid component in the hyposecretory dry eye treatment. Patients and methods. We examined 35 hyposecretory moderate dry eye (DE) patients in conditions of lipidaquas-mucin deficiency and meibomian gland dysfunction (MGD). All patients included in the study received instillations of a fixed combination of 0.24 % hyaluronic acid (in the form of sodium hyaluronate), carbomer, glycerol and a lipid component (in the form of medium chain triglycerides) — Artelak Night (3 times a day, 2 months). The main criterion for the effectiveness of therapy was the tear film brake up time (TBUT, Norn’s test, s). In addition, the dynamics of the following indicators were taken into account: OSDI (scores), “lid-wiper’ symptom (LWS, scores), lower tear meniscus height (LTMH, μm; OCT, OptoVue), Bijsterveld`s xerosis index (XI, scores; lyssamine green stained). Control points: at inclusion in the study; examination after 1 and 2 months of therapy. Statistics: calculation of the mean and its standard deviation (M ± s); assessment of the reliability of differences in indicators characterizing the state of the ocular surface before and after therapy (Wilcoxon t-test). Results. The patients showed a statistically significant increase in TBUT at the second and third control points, which indicated the effectiveness of DE therapy. The increase in TBUT was accompanied by a significant decrease in the severity of DE subjective symptoms at the same control points (OSDI). On the background of therapy, a trend towards a decrease in LWS was recorded, which was statistically insignificant. Apparently, a significant increase in TBUT and a decrease in OSDI were associated with a significant increase in LTMH at the third control point (decrease in the severity of aqua-deficiency) and a significant decrease in XI at the second and third control points (decrease in the severity of mucose-deficiency). Conclusion. A fixed combination of 0.24 % hyaluronic acid, carbomer, glycerol and a lipid component proved to be effective in the treatment of hyposecretory moderate DE in conditions of lipid-water-mucin deficiency, which was accompanied by a significant increase in TBUT and LTMH, as well as a decrease in OSDI and XI.
A Clinical Case of Successful Penetrating Keratoplasty after Corneal Perforation that Occurred against the Background of Dacryoadenitis
Authors: Arzhimatova G. Sh. , Slonimskij Yu. B. , Salikhov E. A. , Shemyakin M. Yu. , Ibraimov A. I.
Published: October 2023

The article presents a clinical case of penetrating keratoplasty performed in a patient after corneal perforation against the background of dacryoadenitis. The importance of the condition of the precorneal tear film for the normal functioning of the cornea and how dry eye syndrome affects the condition of the cornea before and after surgery are discussed. Relevant and open, in the article, remains the issue of the development of such complications as a corneal ulcer with perforation, against the background of dry eye syndrome that developed more than 10 years after the keratorefractive operation. Data on the state of the penetrating corneal graft after 6 months of dynamic follow-up are presented.
New concept and algorithm for the management of patients with chronic obstructive pulmonary disease
Authors: Avdeev S. N. , Leshchenko I. V. , Aisanov Z. R.
Published: October 2023

Currently, chronic obstructive pulmonary disease (COPD) is a global problem and one of the leading causes of death worldwide. COPD therapy includes pharmacological and non-pharmacological approaches that can significantly reduce clinical symptoms and decrease the frequency of exacerbations of the disease. Methods. The updates of guidelines for the diagnosis and treatment of COPD is expected to have a significant impact on patients with COPD in clinical practice. Simplification of the treatment algorithms and inclusion of triple therapy will help clinicians provide appropriate and timely treatment to patients with COPD with a focus on reducing the risk of future exacerbations. Recognition of mortality reduction as a treatment goal in COPD supports the increased use of triple therapy, the only pharmacologic intervention shown to improve survival in patients with COPD. Conclusion. Although further guidance and clarification are needed in some areas, such as the use of blood eosinophil count in treatment decisions and the implementation of post-hospitalizaton treatment protocols, the recent guideline updates will help clinicians address current gaps in patient care.
Dynamics of functional changes in the respiratory system after COVID-19-associated lung injury at one year after hospital discharge
Authors: Chernyak A. V. , Mustafina M. Kh. , Naumenko Zh. K. , Kalmanova E. N. , Zykov K. A.
Published: October 2023

Morphological examination reveals microcirculation disorders in combination with small areas of lung damage in the long term after COVID-19. Therefore, the function of the respiratory system should be assessed after COVID-19. Aim of this study was to evaluate the dynamics of respiratory dysfunction in patients with COVID-19-associated lung injury using a complex examination of lung function (spirometry, body plethysmography, and lung diffusion testing) one year after hospital discharge. Methods. 60 patients (38 men/22 women, aged 39 to 80 years) with a diagnosis of “COVID-19-associated interstitial process in the lungs” were examined. Lung function (spirometry, body plethysmography, and lung diffusion capacity testing) was examined in all patients twice, at 1 – 6 months (visit 1) and at 12 – 24 months (visit 2) after hospital discharge. Results. At visit 1, 60% of patients had restrictive pulmonary ventilation disorders. Obstructive ventilation disorders were detected in only 1 patient. Decreased lung diffusion capacity (D CO corr.) was found in 78% of patients. At visit 2, obstructive disorders were detected in 1 patient, and the frequency of restrictive ventilation disorders was 29%. Decreased DLCO corr. was noted in 57% of cases. The parameters of pulmonary ventilation and pulmonary gas exchange function differed significantly between visits. Significant correlations were found between changes in the functional parameters of the respiratory system and disorders identified at visit 1 after hospital discharge. Conclusion. Thus, there is a decrease in the lung diffusion capacity and the rate of restrictive ventilation disorders even one year after severe COVID-19-associated lung injury. However, our results suggest a marked improvement in respiratory system function over time.
Micosis fungoide estadio III, enfermedad eritrodérmica: reporte de caso
Authors: Ruilova González Lizbet Yolanda , Vázquez Gárate María Gracia , Feijó Erazo Joseph Mateo
Published: October 2023

Introducción: la micosis fungoide (MF) es el linfoma cutáneo más común que se produce por una proliferación monoclonal de linfocitos T malignos cuyo órgano blanco primario es la piel; es más frecuente en el sexo masculino y en mayores de 50 años, siendo raro en jóvenes.  El curso clínico en la piel es insidioso, las lesiones parten de una erupción macular eritematosa con descamación a máculas, placas, tumores y eritrodermia pudiendo afectar a gran parte de la superficie cutánea.
Caso clínico: paciente de 25 años, que presenta inicialmente una lesión cutánea eritematosa, seca y descamativa en la cara anterior de muslo de 2 cm, con periodos de exacerbación y remisión, evoluciona hasta comprometer el 80% de la superficie corporal respetando únicamente la cara, cuello y pliegues axilares e inguinales, se realizó biopsia con diagnóstico de micosis fungoide. Tratado con antimetabolitos, modificadores de la respuesta inmunológica, ácido fólico, antibióticos y analgésicos, presentando una evolución favorable.
Conclusiones: la micosis fungoide puede presentarse en jóvenes como en el paciente a los 13 años con lesiones dérmicas, la demora en el diagnóstico ocasionó un compromiso que alcanzó hasta 80% de la superficie corporal, diagnosticándose de etapa T4NXM0 B0, estadio clínico III luego de terapia específica obtuvo respuesta y evolución favorable.
El equipo de neurodesarrollo en la sospecha clínica del Síndrome de Williams (SW): reporte de caso.
Authors: Huiracocha Tutiven María de Lourdes , Newell Glen , Marín Cordero Andrea Estefanía , Bermeo Serrano Jéssica Dayanna , Calderón Siguencia Mariela Cecilia , Espinoza Alcalá Kwan Yin Estefanía , Mogrovejo Barros Mónica Marlene , Campoverde Vizhñay Johanna Lucía
Published: October 2023

Introducción: en la ruta diagnóstica de los niños con Retraso Global del Desarrollo (RGD) se encuentra la identificación de malformaciones y la derivación a especialistas para la determinación del síndrome genético que oriente la intervención y el pronóstico.
Caso clínico: niño de 5 años de edad diagnosticado por el equipo de neurodesarrollo (pediatra, estimuladora temprana, fonoaudióloga, fisioterapeuta) de RGD por presentar problemas de atención, alteración neurológica, selectividad alimentaria, disfagia orofaríngea.  Además, por delgadez severa, características faciales, estenosis supravalvular aórtica severa con hipoplasia de arco aórtico se considera alta sospecha de Síndrome de Williams (SW), se solicitó examen confirmatorio, el test de FISH, mismo que no se realiza por limitaciones en la cartera de servicios del Estado ecuatoriano. Plan terapéutico: tratamiento cardiológico; plan de intervención en neurodesarrollo: estímulo de actividades de la vida diaria, mejora de las habilidades de comunicación, introducción de alimentos nuevos en texturas y sabores, optimización de la independencia en la movilización, fortalecimiento de las competencias parentales y evaluaciones periódicas.
Conclusiones: la participación del equipo de neurodesarrollo resulta esencial para proporcionar una atención integral a pacientes con SW, la colaboración entre diferentes profesionales con diversos conocimientos y perspectivas puede mejorar la calidad del diagnóstico y aumentar las posibilidades de éxito en la intervención. Existieron limitaciones en la confirmación del diagnóstico por la ausencia de determinación del test de FISH en la cartera de servicios en el sistema de atención salud estatal.
Evaluation of the clinical value of sodium examination in spot urine in patients presenting with acute heart failure while using SGLT2i – ‘‘SPOT HF STUDY’’
Authors: ASLAN Onur , DEMİRCİ Emre Emrah
Published: October 2023

Objectives: Sodium measurement in spot urine provides important information about the adequacy of the initial dose in acute heart failure (AHF) patients using intravenous diuretic (IV) and makes a guiding contribution to the titration decision. It is not clear whether spot urine sodium measurement has the same clinical value as the effect of sodium-glucose cotransporter 2 inhibitor (SGLT2i) drugs on urinary electrolytes. Our aim in our study is to investigate the clinical value of sodium examination in spot urine in AHF patients while using SGLT2i.
Methods: Our study was conducted retrospectively and single-centered. AHF patients, administered IV diuretics were included in the study. Patients who were using and were not using SGLT2i were examined in two groups. The 2nd and 6th-hour sodium values in spot urine were measured.
Results: Patients using SGLT2i (n = 46) and not using it (n = 54) were included. The mean age was 69.91 ± 11.84 years and 47% were female. The standard deviation value for the sodium in spot urine in patients using SGLT2i was clearly high and its distribution was significantly higher. A weak correlation was found between the sodium value in spot urine and the 24-hour urine volume in this group. Hospitalization history within 1 month after discharge was found to be 39% in the group using SGLT2i, and 51% in the group that did not use it, and this difference was statistically significant.
Conclusions: The measurement of sodium in spot urine does not seem to have the same clinical value in HF patients using SGLT2i. Its correlation with urine volume is also decreasing in this group.
Art Therapy as an Effective Means of Overcoming Stress: Neurophysiological Features
Authors: Kramchenkova Vira , Nazarevych Victoriia , Kompanovych Marianna , Boreichuk Iryna , Dziuba Tetiana , Panasiuk Anastasiia
Published: October 2023

The article presents the results of research into the use of the most effective means to overcome stress in children and adults, in particular, the use of art therapy. The relevance of the study is determined by the need to build stress resistance in crisis situations, which are a fairly common phenomenon in the context of modern problems.
The study defined the essence of the concepts of "fear", "anxiety" and "art therapy". Aspects related to the impact of stress on children, its causes, and the main trends in overcoming it were formed. The work describes art therapy as one of the most effective methods of preventing stress and building stress resistance. The results of the study confirm the hypothesis regarding the use of art therapy as a method of overcoming stress and at the same time as prevention. The most effective means of overcoming stress have been determined, in particular fairy-tale therapy, art therapy, etc. The causes of stress as neurophysiological features in a child were also investigated. The prerequisites and factors of stressful situations are characterized. Methods of synthesis, analysis, research, scientific and descriptive methods were used to ensure an effective research result. The research became the basis for determining ways to overcome stress, for the formation of effective means of diagnosis and psychocorrection. To determine effective approaches to overcoming stress, scientific research on the problem was analyzed and features were determined. The results of the study became the basis for establishing the features of stress in crisis conditions, analyzing the most effective methods of overcoming stress, describing neurophysiological factors that cause stress, and characterizing art therapy as the most effective method of overcoming stress. The article is the result of research and analysis of scientific intelligence on the specified problem.
Psychological Features of Adolescent Children's Tolerance Development as an Actual Problem of Inclusive Practice
Authors: Kozynets Oleksandr , Korniev Serhii , Ponomarova Vira , Maliarchuk Natalia , Polovyk Olha , Shcherbakova Iryna
Published: October 2023

One of the indicators of psychological safety of an inclusive educational environment is the tolerance of adolescent children. The article presents the consideration of this indicator through the prism of tolerance, which allowed us to identify three types of attitude of junior schoolchildren with normotype development to those developing atypically: intolerant (negative), neutral, tolerant (positive). The identified types of tolerant attitude of junior schoolchildren are correlated with the levels of interaction: pre-subject, subject-object, subject-subject (activity-value and polysubject). The empirical research that allowed to reveal the prevailing types of attitude and corresponding levels of interaction of junior schoolchildren: neutral attitude - subject-object type of interaction and tolerant attitude - activity-value type of interaction with obvious deprivation of the polysubject type of interaction is presented. The article clarifies the concept of tolerance towards children with special educational needs. The article reveals the indicators and levels of teacher's competence in fostering tolerance of junior schoolchildren in relation to peers with special educational needs. The article defines the psychological features of adolescent children with different types of pathological disorder; investigates the role of psychological safety of inclusive educational environment in the formation of tolerance of adolescent children; makes a structural and functional analysis of tolerance of adolescent children as a relevant problem of inclusive practice; defines the role of the teacher in the formation of tolerance of adolescent children as a relevant problem of inclusive practice.
Ethics of New Technologies in Distance Learning of a Foreign Language: a Neuroscientific Approach
Authors: Sidun Larysa , Borysenko Iryna , Pinchuk Larysa , Ahibalova Tetiana , Karachova Daria , Gurevych Roman
Published: October 2023

The article proves that in recent years important advances have been made in neurobiology regarding education. With advanced scientific knowledge of cerebral activity in learning, educators have the opportunity to use interesting tools to improve academic performance in higher education when teaching a foreign language. Based on research on brain function, educators have created distance-learning tools useful for teaching a foreign language. While these tools are an important and critical element of the learning process, the emphasis in this study is different, that is, to teach students to become familiar with their own brain function and then to mobilize their metacognitive resources during distance learning. In this regard, teachers have faced many issues of organizing feedback from the study group, transferring learning materials to distance education platforms, monitoring progress and many others, while engaging the metacognitive resources of students. The issue of formation of information and communication and neurocompetence of foreign language teachers has become especially urgent in the pedagogical environment. Due to the lack of relevant skills, teachers had to adapt to the new educational conditions and completely restructure the educational process.
Medical Thinking in the Light of Classical, Non-Classical and Post-Non-Classical Rationality
Authors: Khmeliar Inesa , Kushnir Lesia , Fylypiuk Dmytrо , Lysytsia Dmytro , Sharapa Ganna , Markovych Oleksii
Published: October 2023

In the modern theory and practice of medical sciences, one can observe the proximity of various types of rationality, which determine both the direction and quality of thinking. This is due both to the heterogeneity of the development of various areas of medical culture and clinical thinking. This determines the relevance and expediency of the study, associated with the need to distinguish between the prevailing methods of rationality of medical thinking; to determine its direction and, accordingly, the effectiveness in the activities of medical workers. The definition of the limitations inherent in a particular type of scientific rationality in relation to medical thinking. This approach makes it possible to overcome the limitations associated with foundations of thinking in one form or another of scientific rationality, thereby expanding the heuristic possibilities of medical thinking itself as such. To achieve the goal of the study, methodological practices of philosophical reflection and analysis of thought processes are used. Classical rationality is characterized by a mechanistic approach to a person; non-classical rationality is characterized by the penetration of researchers into the microcosm and a corresponding expansion of ideas about reality; post-nonclassical rationality is characterized by a search for integrity and interactions, as well as human-dimensional research practices. The main conclusion arising from the study was the statement that medical thinking is characterized by the use of various types of rationality, which determines both the deontological approach to the patient, based on appropriate medical anthropology, and the choice of strategies and methods of treatment.
The Teacher's Role in the Use of E-learning Technologies for English Language Learning in Higher Education: the Neural Impact of Electronic Services on the Student's Brain
Authors: Stepanenko Olena , Rudnianyn Oksana , Nefedchenko Oksana , Oleinikova Galyna , Kostenko Natalia , Kutsenko Iryna
Published: October 2023

The process of globalization affects all areas of the education system, necessitating the correlation of the sphere of professional activity with the requirements for the competence of a modern specialist. Mastering the current information and communication space determines the need to master the unified tool of interaction technologies of e-learning English in higher education institutions. Future graduates of higher education institutions, no matter what field they work in, need skills that promote interaction, implementation of professional self-development. Training highly professional specialists with not only theoretical knowledge and practical skills in their specialty, but also advanced means of communication, electronic platforms, knowledge of a foreign language is fully consistent with the main task of the university. Knowledge of a foreign language contributes to professional culture, creates opportunities to freely navigate in the studied scientific research from the field of knowledge. Higher education professors face the task of not only creating the conditions for learning a foreign language, but also to purposefully motivate students to master it as a necessary competence for carrying out professional activities. The study of a foreign language should be professionally oriented, contribute to the solution of cognitive and communicative needs of students. The article researches the most effective e-learning technologies in English classes in higher education institutions (HEI); defines the role of the teacher when using e-learning technologies of English language in higher education institutions; describes the educational centers and platforms for e-learning; defines the neural influence of electronic services on the brain of the student.
Neuropedagogical Features of Communication in the Process of Online Education
Authors: Honcharuk Nataliia , Onufriieva Liana , Haletska Yuliya , Kurytsia Denys , Ivashkevych Ernest , Nabochuk Alexander
Published: October 2023

The article reveals the features of communicative interaction with students in conditions of quarantine restrictions and martial law. The aim of the study is to analyze the psychological issues of the organization of distance learning of adolescents and young people and determine, based on this, the main directions and technologies of pedagogical communicative interaction. The objectives of the study included the following features of the work: 1) determining the theoretical and methodological foundations of distance learning; 2) analysis of the main issues and psychological features of pedagogical-student communication in terms of distance learning; 3) elucidation of psychological and pedagogical ways and technologies of pedagogical interaction in the period of quarantine restrictions.
The article presents the peculiarities of the educational process during the quarantine period as an aspect of neuropedagogy, defines the peculiarities of communication with children when using information and communication technologies. To study the processes of further immersion in the essence of brain behavior in the digital stream, the formation of new neuropedagogical knowledge is necessary to understand how to make learning and, more broadly, socialization a pedagogically controlled process in this new environment.
Changes in Mineral Profiles in Progesterone-based Estrus Induction Protocols and their Relationship with the Phases of Estrous Cycle in Kangayam Cows
Authors: Lakshmikantan U. , Selvaraju M. , Palanisamy M. , Selvaraj P. , Vasanthakumar P. , Mathivanan R.
Published: October 2023

Background: For the successful reproduction in Kangayam cows, adequate nutrition containing sufficient quantum of minerals is necessary. Minerals are important cofactors in majority of the metabolic and immune reactions and hormone synthesis that could affect reproduction. Present study was planned to analyse whether mineral levels change in different treatment days following estrus induction and corresponding changes in stages of the estrous cycle. Methods: Non pregnant, pluriparous Kangayam cow (n=70) were allotted to control and different treatment protocols (each consist of 10 cows) based on the transdermal (PNC based groups) and transvaginal application of progesterone (CIDR based group) with a shot of PGF2α one day preceding the day of progesterone removal. Ovulation was induced either using estradiol benzoate or buserelin acetate. Mineral profiles were analysed on the day of progesterone application (APP), removal (REM), AI and 10 days post insemination (10 DPAI). Result: It indicated that changes in the mineral levels between the treatment days especially on the day of AI and 10DAPAI could be correlated with the corresponding follicle and luteal phases and it could be concluded that there were significant changes especially in selenium, manganese, zinc and copper levels between the treatment days in each group which could be extrapolated to have specific roles in stages of estrous cycle. Among these minerals copper levels could be correlated to affect the steroid concentration by altering its metabolism thereby its clearance in Bos indicus breed ie Kangayam breed of Tamil Nadu.
Enhancing Food Security Through Identification of Best Performing Barley Cultivars under Arid Conditions
Authors: Al-Ragam O. , Al-Menaie H.S. , Al-Shatti A. , Babu M.A.
Published: October 2023

Background: Plant genetic diversity is the key to the development of new crop varieties for enhanced crop production and improvement of food security. Barley is one of the most dependable cereal crop under saline and drought conditions and used majorly in feed, food and malting industry. The growth and yield of barley is highly influenced by the production environment and genotype. Methods: The study evaluated the growth and yield performance of fourteen barley genotypes under Kuwait’s environmental conditions. The field trials were conducted in Kuwait for two successive seasons 2019-2020 and 2020-2021 in a randomized complete block design with three replicates. Result: The combined analysis of variance has shown that plant height, number of tillers/m2, number of days to heading, hundred kernel weight, grain and biomass yield varied significantly between the fourteen different barley varieties. Similarly, all the parameters varied significantly between the years except hundred kernel weight. In addition, an interaction was observed between genotype and year, for all parameters except hundred kernel weight, biomass yield and number of tillers/m2. Taking into consideration the two growing seasons, the varieties Kuwait 3 and Kuwait 4 presented superior performance over other varieties in terms of grain and biomass yield under Kuwait’s harsh environmental conditions.
THE IMPACT OF POLITICAL MARKETING PERCEPTION ON POLITICAL PARTICIPATION
Authors: ÇAĞLAR Nedret , AKBIYIK Ferdi
Published: October 2023

The leading objective of this study was to explore the impact of political marketing perception on political participation. For data collection, an online form was created through Google Forms and distributed to female voters living in Isparta who were over 18 years of age and eligible to vote in elections. Out of a total of 544 female participants who volunteered for the study and achieved the questionnaire in its wholeness, were contained in the analysis. Simple random sampling was engaged in this descriptive research model. Afterwards, the data were exposed to various statistical tests, including “Reliability,” “KMO test,” “Factor Analysis,” and “Regression Analysis,” using the SPSS 21 package program to specify the effect of political marketing perception on political participation in accord with the proposed research model. Seven factors were discovered in the dimensions of political participation among female voters, with each factor being labeled rooted in the items that built it. These factors were named as “Political Support,” “Preference Reason,” “Political Product,” “Media and Interest,” “Reward,” “Candidate,” and “Social Structure,” respectively. Additionally, three factors were identified in the dimensions of political marketing among female voters, and each factor was named based on the items that made up it. The factors were designated as “Marketing Communication,” “Advertisement,” and “Visibility,” accordingly. The study revealed that strong marketing communication could potentially deliver as a dynamic strategy to enhance a candidate’s performance and reputation in the opinion of voters. In this regard, political parties and candidates may take into consideration boosting their investment in marketing communication efforts to enact an improving connection with voters and manage a positive image.