bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of antidepressant and nootropic activities of leaf extracts of Rhizophora apiculata
Authors: Mande Annie , Malothu Narender , Areti Anka Rao , Guntupalli Chakravarthi
Published: August 2024

Background

Rhizophora (R.) apiculata is a traditional mangrove plant having antioxidant, anti-inflammatory, and central analgesic activities.

Objective

The current study was performed to assess the beneficial neurological activities of the plant using rodent models and also to explore the phytochemical distribution of plant extracts using the hyphenated analytical technique.

Materials and methods

Ethyl alcohol and aqueous extracts were subjected to phytochemical screening, followed by GC-MS analyses. In experimental studies, the animals were divided into normal, positive control (standard), negative control, and extract-treated groups at three doses of each extract. The tail suspension method and forced swim tests were used as requisite animal models for the evaluation of antidepressant activity. Imipramine was used as the standard drug for the evaluation of antidepressant studies. Nootropic activity was evaluated by using the radial arm maze and Y-maze models. For these studies, scopolamine was used to impair the cognition of the animals and donepezil was used as the standard drug. The results were displayed as mean±standard error mean, and two-way ANOVA was used to analyze statistical significance between the test groups.

Results and conclusion

Preliminary phytochemical analyses showed that the leaves contain a wide range of secondary metabolites in abundance. As per GC-MS characterization, a few bioactive compounds like 3-O-methyl-D-glucose, desulphosinigrin, 1,25-dihdroxy vitamin D3, and ethyl iso-allocholate were identified. Ethyl alcohol extract (at 300 mg/kg; and 600 mg/kg) and aqueous extract (at 200 mg/kg; and 400 mg/kg) of R. apiculata exhibited antidepressant activity in both models. The plant extracts were proved to have cognition-enhancing activities at tested doses. The results stated that the plant R. apiculata is proved to have antidepressant and cognition-enhancing activities. Thus, it may provide a chance in the therapeutic management of neurological ailments. The effects of leaf constituents on brain neurotransmitter levels and the histology of the brain need to be established by future investigations.
Moringa (Moringa oleifera) leaves aqueous extract enhances fibronectin type III domain-containing protein 5 gene expression and serum irisin liberation in an obesity model
Authors: Abdellah Reem K. , El-Beih Nadia M. , Morsy Fatma A. , Abdel-Wahhab Khaled G. , El-Hussieny Enas A.
Published: August 2024

Background

Obesity, a risk agent for many chronic diseases, leads to increased mortality and poses one of the major public health problems.

Objective

This study aimed to investigate the thermogenic and antiobese efficiency of Moringa aqueous extract (MAE) on obese-modeled rats.

Materials and methods

Adult male rats (150–170 g) were randomly divided into four groups, with 10 animals each, as follows: (a) healthy rats served as control, (b) healthy rats administrated with MAE (400 mg/kg/day), (c) obese-modeled rats, and (d) obese-modeled rats treated with MAE.

Results

After 30 consecutive days of treatment, the obtained results declared that MAE possessed antiobesity, thermogenic, antilipidemic, and antiinflammatory potential. MAE succeeded significantly in reduction of the BMI and serum leptin level coupled with up-regulation of fibronectin type III domain-containing protein 5 gene mRNA expression and serum irisin level. It clearly increased serum paraoxonase-1 activity and improved lipid profile values. Moreover, it markedly reduced serum tumor necrosis factor α and increased antioxidant activity, which was achieved from the marked improvement in malondialdehyde, nitric oxide, catalase, superoxide dismutase, and glutathione values in cardio-hepatic tissues. These findings were confirmed by the regeneration of the hepatic histopathological structure.

Conclusion

MAE, as a food supplement, could play a beneficial role in management of obesity and restoring its complications. This could be exhibited through multiple pathways, mainly via upregulation of fibronectin type III domain-containing protein 5 gene expression and production of the soluble myokine ‘irisin,’ which is responsible for browning of white adipose tissue as well as increment of total body energy expenditure.
Insights on the inhibitors of dipeptidyl peptidase 1 as mast-cell stabilizer
Authors: El-Feki Ghada M. , EL-Desouky Mohamed A. , Badway Mohamed A.
Published: August 2024

Background Tryptase and chymase are potent proteases secreted by mast cells upon activation. These abundant mast-cell proteases are converted into catalytically active forms by dipeptidyl peptidase 1 (DPP1). DPP1 is one of the most important components to initiate chain reaction for triggering the inflammatory response mediating allergic diseases such as asthma and allergic rhinitis. DPP1 can remove the safety catch on various mast-cell proteases, including tryptase and chymase, and plays an essential role in controlling their activity. However, the exact role of DPP1 in mast-cell degranulation is still not fully recognized.

DPP1 may help mast cells degranulate via acting inside the cell or after secretion. DPP1 inhibitors are essential for mast-cell stabilization. In this review, we will discuss the contribution of DPP1 in mast-cell degranulation and the role of DPP1 inhibitors in mast-cell stabilization, which may help finding new therapeutic strategies for asthma.
Review on EGFR-ERK1/2 signaling cascade: implications on cell proliferation in health and disease
Authors: Abo-El Fetoh Mohammed E. , Abdel-Fattah Maha M. , Afify Hassan , Ramadan Laila A.A. , Mohamed Wafaa R.
Published: August 2024

Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is often increased in malignancies such as non–small cell lung cancer, metastatic colorectal cancer, head and neck cancer, pancreatic cancer, and breast cancer. EGFR activity may be enhanced by different ways. These include typical mutations and truncations in the extracellular domain, and in the kinase domain. Overactivation of downstream ERK1/2 signaling pathway occurs as a result of these EGFR abnormalities. Cancer cell proliferation is aided by the chronic start and advancement of the cell cycle, which is triggered once these pathways are activated. This article discusses the ligand-binding and dimerization molecular processes that control EGFR signal transmission and its relationship to the ERK1/2 signaling axis that forces cells toward the G1 phase of the cell cycle. Furthermore, it illustrates how EGFR signaling pathways promote cyclin D expression via ERK1/2 activation.
Production and partial purification of an innovative heat resistant α-keratinase with some remarkable medical and industrial applications
Authors: Esmail Safi S. , Hassan Amira A. , Easa Saadia M. , Ismail Abdel-Mohsen S.
Published: August 2024

Background and objectives

Keratinase has ultimate practical importance in industry, medicine, food industry and waste management fields. Their applications in wool and silk are as good cleaners and in leather industry as the best ever green dehairing agents providing high leather quality, as well they are used as crucial components of sophisticated detergents. Their medical prospective applications are in prion degradation and human callus removal. They convert keratinaceous wastes to valuable products saving the environment from hard keratin waste pollution. Bacteria, fungi and actinomycetes are effective keratinase producers and they are considered the most suitable sources. This study aims to formulate the production medium and to pinpoint the proper physiological conditions for the potent microorganism producing an efficient α-keratinase enzyme. The partial purification of the crude enzyme was successfully performed. The effect of the reaction temperature on both the crude and the partially purified enzyme (PPE) was duly studied with the thermostability of PPE. Some important applications have been implemented on PPE and these include leather dehairing, cloth stain removal, and topical treatment of human callus.

Materials and Methods

Thirteen recommended microbial strains were screened for effective and applicable α-keratinase productivity. Optimization of the cultural conditions for extracellular enzyme production and also the partial purification of the crude enzyme by ammonium sulphate salting out or by ethanol or acetone precipitation were carried out. The effect of reaction temperature on the enzyme and its thermostability were studied. Finally, the efficiency of the PPE on leather dehairing, stain removal, and human callus treatment was explored.

Results and conclusion

Among the 13 organisms screened, the fungal strain Trichoderma polysporum HZ-31 was the most potent producer of an influencial α-keratinase. The maximum α-keratinase activity of 58.2 UmL−1 was obtained by the previous-mentioned strain after 5-days fermentation medium containing (%, w/v): whole chicken feathers 0.5, glucose 0.2, peptone 0.5, yeast extract 0.5, K2HPO4 0.1, KH2PO4 0.3, CaCl2 0.1, MgSO4 0.1, and pH 7.0. Acetone fractionation of the crude keratinase was the most proper and offered the most promising keratinase fraction PPE at 80–90% acetone. This fraction had high thermostability and was kept at 55°C for more than 98% of its original activity after 60 min heating and this temperature (55°C) was also the optimum for 2 h enzymatic reaction. Conclusively, the present study succeeded in the achievement of a constitutive extracellular alkaline α-keratinase, which successfully proceeded to complete leather unhairing after 12–16 h at 37°C, afforded high performance to cloth blood stain removal with Arial detergent after 2 h at 50°C and complete degradation of the human callus after 4 h at 50°C.
Red-pigment production by Talaromyces atroroseus TRP–NRC from soybean mill via solid-state fermentation
Authors: Fadel Mohamed , Elkhateeb Yomna A.M.
Published: August 2024

Background

Color of food is important to appear its freshness, safety, good processing esthetic, and nutritional values. In the recent years, production of biopigments from natural sources as an important alternative to harmful synthetic dyes is of worldwide interest.

Objective

This study focused on the production of red pigment from local isolated fungus Talaromyces atroroseus TRP–NRC by cultivation and optimization of production on soybean mill under solid-state fermentation system.

Materials and methods

A novel local non-mycotoxin-producing fungus T. atroroseus TRP–NRC, which is isolated from Egyptian compost and deposited in the gene bank under accession number MW282329, was grown on some agricultural wastes producing industrially red pigment under solid-state fermentation system. About 250-ml conical flasks containing 5 g of substrate, moistened with moisten solution to demand level. The flasks were sterilized, inoculated, and incubated under static condition at 30°C. Studies were conducted for optimization pigment-production conditions, Solid: moisture ratio was tested, 2% of the different carbon sources and equivalent level of nitrogen mg/g substrate were examined. Various pH was adjusted. The effect of incubation temperature was carried out over a range from 20 to 35°C, and the effect of incubation period on pigment production was studied over a range of 5–14 days. Red pigment was extracted from fermented soybean mill with 90% ethanol, solvent was removed using a rotary vacuum evaporator. Estimation of the extracted pigments was done by measuring the absorbance by spectrophotometer OD value at 500 nm.

Results and conclusions

A novel local non-mycotoxin-producing fungus T. atroroseus TRP–NRC was grown on some agricultural wastes for producing red pigment (0.129 g/g soybean original substrate) that were achieved under solid-state fermentation system. The highest production yield of red pigment was reached where the initial pH value was 2.5, temperature 25°C after 7-day incubation when the fungus cultivated in fermentation vessel occupied by 2% w/v soybean mill moistened at solid : liquid ratio 1 : 3. Production of red biopigment shows the advantage of mannitol supplementation as carbon source with soybean for increasing pigment by fold. Pigment production was affected positively by addition of organic nitrogen, especially yeast extract higher than addition of inorganic sources and NH4HSO4 more suitable than the other tested sources after 7 days. High yield of red pigment (mg/g utilizable soybean) makes the production more economical and encourages to be useful in industrial application.
Repurposing of available antiviral drugs against SARS-CoV-2 by targeting crucial replication machinery proteins
Authors: El-Sayed Ahmed F. , Mohammed Amira T. , Hamed Wafy , Abdelmalek Shaymaa
Published: August 2024

Background and objectives

The newly emerged severe acute respiratory syndrome coronavirus is spreading worldwide rapidly with increasing incidence rates. Due to lack of effective treatments and vaccines, various drug repurposing studies are being developed. Searching for available antiviral drug libraries is the best and fast option to advance to clinical trials and spread their application among infected patients.

Materials and methods

Molecular docking study was performed utilizing AutoDock 4.2 system and Discovery Studio 4.5, which were utilized to predict the activity pocket of the target proteins.

Results and conclusion

The results found that the interacting affinities resulted from the molecular simulation of 3CL protease with ligands Ledipasvir, Sofosbuvir, Ribavirin, Galidesivir, Tenofovir, and Remdesivir were −7.2, −7.4, −7.2, −6.3, −6.1 and −6.6 kcal/mol, respectively. Similarly, the interacting energies obtained from the docking of RNA helicase with ligands were −7.9, −7.4, −6.4, −7.9, −6.2, and −6.9 kcal/mol. Also, the binding energies obtained from the docking of 3′-5′ exoribonuclease with ligands were −10.6, −10.1, −6.5, −7.1, −6.1, and −9.3 kcal/mol. Finally, the binding energies score from the docking of the RNA-dependent RNA polymerase with ligands was −9.6, −6.9, −6.2, −6.6, −6.7, and −6.4 kcal/mol. Based on the binding energy score and docking result, Ledipasvir and Sofosbuvir have a higher affinity of the drug molecule such as against RNA-dependent RNA polymerase, exonuclease, and 3CL protease. Besides, Ledipasvir and Galidesivir show prominent binding interaction with severe acute respiratory syndrome coronavirus RNA helicase. The results are promising for evaluated drugs especially Ledipasvir and Sofosbuvir and could be useful in emergency treatment of coronavirus disease 2019 patients.
The antibacterial and antibiofilm activity of Lactobacillus acidophilus isolated from vagina against methicillin-resistant Staphylococcus aureus
Authors: Jameel Aleaa A. , Abdullah Amenah R. , Hussein Sahar I.
Published: August 2024

Background

Bacterial infections caused by the genus Staphylococcus represent a grave threat to both humans and animals, and they are a major concern to health authorities. Over the past few decades, methicillin-resistant Staphylococcus aureus (MRSA) has been recognized as the principal nosocomial pathogen worldwide.

Objective

To investigate the antibacterial and antibiofilm activity of Lactobacillus acidophilus against locally isolated MRSA at different concentrations.

Materials and methods

MRSA isolates were tested against some antibiotics for testing antibiotic sensitivity. The antibacterial activity of L. acidophilus based on the minimal inhibitory concentration (MIC) of L. acidophilus that inhibits the visible growth of MRSA isolates was assessed using the microdilution method. Estimation of MIC of L. acidophilus was done. Biofilm quantification assay was then used for the determination of the antibiofilm activity of L. acidophilus. The MIC concentration was assessed by a microtiter reader.

Results and conclusion

The antibacterial activity was tested by agar diffusion method and broth microdilution method. The microdilution method was used to determine the MIC of L. acidophilus, whereas the antibiofilm activity was determined by using 96-well polystyrene microtiter plates. The results revealed that L. acidophilus has antibacterial activity in a concentration-dependent manner. The average diameter zone of inhibition observed against MRSA isolates ranged from 11±0.5 to 18±0.5 mm Moreover, at subinhibitory concentration, this extract developed an isolate-specific antibiofilm effect and presented highly significant (P<0.05) variability in biofilm formation before and after addition of L. acidophilus. AA3 and AA12 isolates gave the lowest and highest antibiofilm activity, respectively. In conclusion, the supernatant of L. acidophilus is a promising alternative medication that can be used to treat the infection caused by MRSA.
Educational framework to train undergraduate medical students in ethics and professionalism in India
Authors: Shrivastava Saurabh RamBihariLal , Suhoyo Yoyo
Published: August 2024

As important as it is that medical doctors must possess comprehensive knowledge and desired skills while interacting with their patients, equal importance must be given to a professional approach and ethical conduct by them. Ethics in the medical curriculum has been explicitly stated, but it would not be wrong to state that exposure to medical ethics has been confined to the time frame when Forensic Medicine is delivered to the students. On the other hand, professionalism in the medical curriculum still remains part of the hidden curriculum, and no specific timeframe has been allocated for the training and assessment of professionalism. Realizing the prevailing lacuna in medical colleges with reference to the training in ethics and professionalism, there is an indispensable need to introduce structured training for undergraduate medical students. To conclude, acknowledging the importance of ethics and professionalism in successful clinical practice, there is an immense need to initiate a systematic educational program targeting ethics and professionalism. The proposed educational program is a holistic and systematic initiative to longitudinally expose medical students to the intricacies of medical ethics and practice professional behaviors.
A retrospective study on the outcome of sepsis among neonates admitted to the neonatal intensive care unit at a tertiary care hospital in Western India
Authors: Das Sayan Kumar , Prajapati Nisha
Published: August 2024

Background:

In underdeveloped nations, sepsis is one of the main causes of newborn death. A timely detection of this can reduce the burden of neonatal mortality as well as morbidity.

Objective:

The aim of this study was to evaluate the prognosis of sepsis at a tertiary care facility in Western India to identify risk factors and increase infant survival rates.

Materials and Methods:

A retrospective study was conducted on neonates admitted between November 16, 2021, and November 15, 2022 (for 1 year duration), at the neonatal intensive care unit (NICU) of GMERS Medical College, Gandhinagar. A dataset was created consisting of neonates with the final diagnosis of sepsis, and the outcome was analyzed based on various parameters.

Results:

Out of 1309 NICU admissions, 130 (9.93%) were sepsis cases. Out of 130 sepsis cases, 72 (55.38%) were male and 58 (44.62%) were female, 62 (47.69%) were inborn and 68 (52.31%) were outborn, and 26 (20%) cases were low birth weight (LBW), 18 (13.84%) were very LBW, 12 (9.23%) were extreme LBW, and 74 (56.92%) were normal birth weight neonates. Out of 130 sepsis cases, 84 (64.61%) cases were preterm, and 46 (35.39%) cases were full-term. In 105 cases, out of 130 total sepsis patients, pathogens were isolated. The most common organism was Staphylococcus (62 cases/59.04%).

Conclusion:

According to this study, the likelihood of developing sepsis was inversely associated with birth weight. A high percentage of neonatal sepsis cases (9.93%) were found, where 96 (73.84%) neonates were successfully discharged. This study is helpful to identify multiple risk factors such as preterm (64.61%), male gender (55.35%), and outborn (52.31%). Antibiotic susceptibility pattern reveals that more number of resistance cases will be coming, posing a serious threat of neonatal sepsis morbidity.
Oral cancer and salivary biomarkers in its early diagnosis: A review of literature
Authors: Nosratzehi Tahereh , Nosratzehi Shahin
Published: August 2024

Oral cancer (OC), the sixth most common cancer, is one of the leading public health problems worldwide, which is mainly represented by oral squamous cell carcinoma. Smoking and alcohol consumption are considered risk factors for OC. The major hindrance regarding OC is delayed diagnosis at the advanced clinical stages (i.e., III or IV), which affects its morbidity and mortality rates with a minimum 5-year survival rate of 20%–25%. Recurrences and metastasis often occur in more than 80% of patients within the first 2 years, even after primary treatment. Although a histological investigation is available as the gold standard of OC diagnosis, the application of noninvasive methods, including liquid biopsy, has been the focus of recent studies. In cancer diagnosis and health surveillance, saliva as a noninvasive and cost-effective bio-fluid containing several biomarkers, including metabolites, circulating tumor and tissue-derived cells, cytokines, DNA, RNA, and exosomes, has promising potential. Therefore, the improvement of salivary biomarkers is an utmost need for early cancer detection, particularly in the oral cavity and oropharynx, which gained the interest of most researchers and clinicians. The current review aimed to discuss the emerging issues of the most recent data on salivary biomarkers with particular attention to the potential early detection markers in OC. In addition, we report our previous findings on salivary biomarkers and their clinical significance as potentials in diagnosis, prognosis, and monitoring of OC.
Direct visualization of postoperative aortobronchial fistula on computed tomography
Authors: Tsuchiya Nanae , Inafuku Hitoshi , Yogi Satoko , Iraha Yuko , Iida Gyo , Ando Mizuki , Nagano Takaaki , Higa Shotaro , Maeda Tatsuya , Kise Yuya , Furukawa Kojiro , Yonemoto Koji , Nishie Akihiro
Published: August 2024

BACKGROUND

Postoperative aortobronchial fistula (ABF) is a rare complication that can occur in 0.3%-5.0% of patients over an extended period of time after thoracic aortic surgery. Direct visualization of the fistula via imaging is rare.

AIM

To investigate the relationship between computed tomography (CT) findings and the clinical signs/symptoms of ABF after thoracic aortic surgery.

METHODS

Six patients (mean age 71 years, including 4 men and 2 women) with suspected ABF on CT (air around the graft) at our hospital were included in this retrospective study between January 2004 and September 2022. Chest CT findings included direct confirmation of ABF, peri-graft fluid, ring enhancement, dirty fat sign, atelectasis, pulmonary hemorrhage, and bronchodilation, and the clinical course were retrospectively reviewed. The proportion of each type of CT finding was calculated.

RESULTS

ABF detection after surgery was found to have a mean and median of 14 and 13 years, respectively. Initial signs and symptoms were asymptomatic in 4 patients, bloody sputum was found in 1 patient, and fever was present in 1 patient. The complications of ABF included graft infection in 2 patients and graft infection with hemoptysis in 2 patients. Of the 6 patients, 3 survived, 2 died, and 1 was lost to follow-up. The locations of the ABFs were as follows: 1 in the ascending aorta; 1 in the aortic arch; 2 in the aortic arch leading to the descending aorta; and 2 in the descending aorta. ABFs were directly confirmed by CT in 4/6 (67%) patients. Peri-graft dirty fat (4/6, 67%) and peri-graft ring enhancement (3/6, 50%) were associated with graft infection, endoleaks and pseudoaneurysms were associated with hemoptysis (2/6, 33%).

CONCLUSION

Asymptomatic ABF after thoracic aortic surgery can be confirmed on chest CT. CT is useful for the diagnosis of ABF and its complications.
KESALAHAN SISWA DALAM MENYELESAIKAN SOAL CERITA PADA MATERI ARITMETIKA: SUATU PENELITIAN KUALITATIF BERDASARKAN PROSEDUR POLYA
Authors: Nedelan Selviani S. D. , Tilaar Anetha L. F. , Regar Vivian E.
Published: August 2024

This research aims to describe the mistakes made by students when solving questions according to the Polya procedure. The type of research used is descriptive qualitative. The method used for data collection consisted of written tests and interviews. A written test was given to 18 students from class VIIC, which consisted of 4 descriptive questions; after that, from the results of the written test, three students were selected to be interview subjects. The interview process was selected based on ability, from those with high, medium and low ability. In this research, the stage used to analyze data is identifying error data according to the Polya procedure. This research shows the mistakes made by class VIIC students of SMP Negeri 11 Manado in solving story questions on Social Arithmetic material. Based on the Polya procedure in solving math story problems on social arithmetic material, it can be seen that the percentage of errors made by students most often occurs, namely errors in rechecking 40%, errors in completing planning 33.84%, planning solutions 30.76%, understanding the problem 26.15 %. Students do not write down what they know and are asked according to the question given, make mistakes in determining the mathematical model used and, do not write down the formula in solving the problem, make mistakes in determining the steps to solve the problem so that they experience errors incorrect calculations and the mistakes that are most often made students do not write down the final answer or are wrong in determining the final answer
Role of KIR like natural killer cell receptors in autoimmune disorders: A commentary
Authors: Agrawal Suraksha
Published: August 2024

Introduction: Autoimmune diseases are complex conditions involving both genetic and environmental factors. Despite numerous studies on the role of immune cells, the exact mechanisms underlying autoimmunity remain uncertain.

Role of NK cells in autoimmunity: Understanding the interplay between cells and cytokines in promoting autoimmunity holds great promise for research. Natural Killer (NK) cells play a significant role in innate immunity by targeting and eliminating cells without the need for prior antigen exposure. Initially, NK cells were thought to contribute to suppressing the immune response due to their potent cytolytic activities.

Recent Advances: Recent research, however, has highlighted their involvement in autoimmunity, particularly through their allele-specific receptors that interact with specific alleles of HLA, contributing to self-tolerance in the immune system's normal development. The role of killer-cell immunoglobulin-like receptors (KIRs) in autoimmune diseases has been emphasized in this review.

Further research: Studies among different ethnic groups have produced inconsistent results, calling for further research to evaluate the functional impact of the KIR gene cluster on various autoimmune diseases. It's crucial to understand receptor-ligand interactions in the context of autoimmunity to uncover how HLA-KIR genotypes act in susceptible or protective ways. Insights gained from such studies may also inform the development of effective treatment approaches.
Management of traumatic fracture-dislocation of the shoulder in children: A systematic review of published case reports
Authors: Ikram Mohammad Arshad
Published: August 2024

Proximal humerus fracture with simultaneous shoulder dislocation in children is a rare occurrence, with few reported cases. This systematic review of case reports aimed to document the outcomes of different treatment methods. A comprehensive literature search from 1980 to 2024 included case reports on traumatic shoulder fracture-dislocation in children. Eighteen studies were included, with a mean follow-up of 1.5 years. The cases comprised 7 boys and 11 girls, aged between 11 months and 16 years (median 6 years). The cases were divided into two groups based on epiphyseal involvement. Group A had 11 cases (61%) with epiphyseal involvement, while Group B had 7 cases (38%) with metaphyseal fractures without epiphyseal involvement. Treatments included closed or open reduction, with or without internal fixation. All fractures healed in an average of 7 weeks, with full function restored in an average of 21.58 weeks. The review suggests that open reduction with K-wire fixation is optimal for Group A, whereas closed reduction with intramedullary fixation is more effective for Group B, offering satisfactory clinical and radiological results in a shorter time efficiently.
Sixth cranial nerve palsy in giant cell arteritis: A systematic review
Authors: Sawada Haruki , Nishimura Yoshito , Tamaki Hiromichi
Published: August 2024

Objectives: This study aimed to review and describe isolated sixth cranial nerve or abducens nerve palsy that may present with subtle ophthalmoplegia in patients with giant cell arteritis (GCA).

Materials and methods: In this systematic review following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) Extension for Scoping Reviews, MEDLINE and EMBASE were searched for all peer-reviewed articles using the keywords “cranial nerve six,” “abducens nerve,” and “giant cell arteritis” from their inception to December 22, 2022.

Results: Twenty-five articles, including seven observational studies and 18 cases, were included. While the incidence and prevalence of sixth nerve palsy in GCA were variable, up to 48% of diplopia in GCA were attributed to the sixth cranial nerve palsy, according to the observational studies included. While 88.2% had a resolution of symptoms with 40-50 mg/day of prednisone-equivalent corticosteroids, it took a median of 24.5 days until the resolution of symptoms from the initiation of treatment.

Conclusion: This review summarizes the current understanding of the characteristics of sixth nerve palsy in GCA. While most patients may have reversible clinical courses, a few can suffer from persistent ophthalmoplegia, which is a potentially missed yet crucial clinical finding in GCA. Increased awareness of the sixth nerve palsy in GCA is crucial.
Neu entdeckte Karikaturen für den Geschichtsunterricht I
Authors: Schnakenberg Ulrich , Held Oliver
Published: August 2024

Entdecken Sie in diesem innovativen Werk bisher unveröffentlichter Karikaturen zu lehrplanrelevanten Inhalten der NS-Zeit. Die sorgfältig ausgewählten Zeichnungen beleuchten die Epoche aus verschiedenen Perspektiven und sind im Doppelseitenprinzip aufbereitet. Jede Karikatur wird begleitet von einer fundierten Interpretation, einer Analyse der Intention sowie einem abschließenden Urteil. Zudem bietet das Buch zu jeder Karikatur didaktisch wertvolle Aufgabenvorschläge, die Ihre Schülerinnen und Schüler zu einer vertieften Auseinandersetzung mit der Vergangenheit anregen. Eröffnen Sie Ihren Lernenden neue Wege zu einer intensiven Beschäftigung mit einem der dunkelsten Kapitel der Geschichte.
Erklärvideos im Geschichtsunterricht
Authors: Dräger Marco , Horn Sabine
Published: August 2024

Erklärvideos sind sowohl im Alltag als auch bildungswissenschaftlich im Zeitalter der Digitalisierung in aller Munde. Sie beinhalten aber nicht nur Chancen für historisches Lernen, sondern bergen auch Risiken. Dieser Band vermittelt den sinnvollen Umgang mit Erklärvideos im Geschichtsunterricht – sowohl auf analytischer Ebene als auch handlungs- und produktionsorientiert. Neben grundlegenden Informationen zu Arten historischer Erklärungen werden Qualitätskriterien für die Analyse und Produktion von Erklärvideos vermittelt. Exemplarisch werden Filme verschiedener Anbieter zu gängigen Unterrichtsthemen analysiert. Checklisten und methodische Hinweise für die Eigenproduktion runden den Band ab.
Subjektgeschichte Politischer Bildung 1955–1980
Authors: Prehm Felix
Published: August 2024

In diesem Werk werden die Ausschlüsse, Differenzen und Marginalisierungen in den didaktischen Konzeptionen und Bildungsmaterialien der Politischen Bildung zwischen 1955 und 1980 rekonstruiert. Der Autor zeigt auf, wie im Diskurs präferierte und nicht-präferierte Subjekte in Differenzmarkierungen konstruiert sind. Auf Basis einer historischen Diskursanalyse sind diese Entwicklungen in den jeweiligen zeithistorischen Kontexten situiert. Die Analyse deckt Transformationen und die zugrunde liegenden epistemischen Ausschlüsse des Fachdiskurses an den kollektiven Subjektkonzepten auf.
Child Gang Involvement in South Africa
Authors: Messow Saskia
Published: August 2024

This volume offers detailed insights into the lives of children in South African townships and informal settlements and their involvement in gangs. Taking a closer look at children in Cape Town's cape flats, this study seeks to understand the reasons why some children join gangs while others stay away. This work explores the overarching and unique backgrounds of children in contact with gangs and the role personal and communal connections play in this context.
Hannah Arendt im Gepäck
Authors: Breier Karl-Heinz
Published: August 2024

Wie können wir in krisenbehafteter Zeit den Sinn für unsere eigene Bürgerschaft stärken? Und welche Denkgewohnheiten können den Kompass unseres politischen Denkens justieren?
Vor diesem Fragehorizont lädt Karl-Heinz Breier dazu ein, mit Hannah Arendt auf Entdeckungsreise zu gehen und sie auf ihren Denkwegen zu begleiten. Als Reisepartner auf ihren leidenschaftlichen Denketappen schließen sich Sokrates und Aristoteles ebenso an wie auch Machiavelli und Montesquieu. Und da es auf dieser weltzugewandten Erkundungstour um unsere Bürgerexistenz geht, sind auch originäre Freiheitsdenker wie Rousseau und Tocqueville mit von der Partie. Hannah Arendt im Gepäck ist eine geistige Erfrischung für jede Reise!
Reseña del Libro: Manejo Integral del Cultivo de Alfalfa
Authors: Núñez-Ramírez Fidel
Published: August 2024

La información recopilada en este libro fue producto de las ponencias presentadas en el curso “Fortalecimiento del Sistema de Producción del Cultivo de Alfalfa en Mexicali, Baja California”, llevado a cabo durante los meses de octubre del año 2013 a junio del 2014. Dicho evento se realizó con el apoyo de Sagarpa, Sefoa B.C., Sistema Producto Alfalfa y el Instituto de Ciencias Agrícolas de la Universidad Autónoma de Baja California. Los temas incluidos en este libro intentan cubrir todos los aspectos relacionados con la producción del cultivo de alfalfa, entre los que destacan: la producción del cultivo de alfalfa en el noroeste de México, el manejo integrado de las malezas, los principios del establecimiento del sistema de riego por goteo en alfalfa, el manejo y control químico y biológico de enfermedades, además del estudio y determinación de los parámetros de calidad del forraje al corte. Especialistas nacionales e internacionales participaron con entusiasmo y con el objetivo de que los trabajos de investigación y las experiencias de campo lleguen al productor y se utilicen en beneficio de una agricultura eficiente y sustentable. Al evento asistieron profesionales y productores del Valle de Mexicali y de San Luis Río Colorado, Sonora. Quien coordinó y editó este documento espera que dicho material sea de utilidad y consulta. Se agradece infinitamente a los autores de cada capítulo, quienes dedicaron parte de su tiempo a la escrituración de su conocimiento, experiencias y recomendaciones. Una presentación en video de este documento, se encuentra en la dirección https://www.youtube.com/watch?v=1veL2mZd2qQ&t=76s; mientras que el libro en físico puede ser obtenido en la librería universitaria (https://ompeditorial.uabc.mx/index.php/deu).
Elaboración de un Sistema De Información Geográfica y Geoportal de Pobreza y Desigualdad en Sonora, México.
Authors: Olmedo Muñoz Mónica , Morales Daniel
Published: August 2024

El artículo muestra la elaboración de un Sistema de información Geográfica (SIG), accesible como un geoportal de acceso público en la plataforma de El Colegio de Sonora, que permite interactuar de manera dinámica con los diferentes datos e indicadores de medición de la pobreza y condiciones de desigualdad, con el fin de crear un anclaje espacial en los análisis y ofrecer la posibilidad de intervención y prácticas significativas en la realidad para la reducción de la pobreza a nivel regional y local. Se presenta el aparato teórico sobre pobreza y desigualdad que permitió la elección de fuentes y variables incluidas en el sistema. Posteriormente se enuncia el manejo metodológico y se presenta el SIG y geoportal conformado por 264 capas de información.
De la Teoría a la Práctica: Explorando las Actitudes Docentes hacia la Inclusión y el Desafío del Autismo (Revisión Teórica)
Authors: DALLI GARCIA LEONOR ARACELI
Published: August 2024

Esta revisión teórica aborda la transformación del paradigma educativo hacia modelos inclusivos que buscan la integración de alumnos con autismo en escuelas regulares. Se destaca la relevancia de la actitud del profesorado en esta transformación, siendo la formación docente un pilar fundamental. A pesar de los avances, persisten dudas sobre la eficacia de dicha preparación, por lo tanto, se examina las actitudes de maestros en diversos países hacia la diversidad e inclusión educativa, identificando diferencias y subrayando la importancia de una formación teórico-práctica. La revisión incluye la presentación de resultados de 11 artículos científicos, destacando características contextuales y paradigmas; se abordan categorías clave, como las actitudes y percepciones docentes hacia la diversidad, obstáculos a la inclusión y aspectos positivos de la escuela inclusiva.
Subproductos de frutos: potenciales ingredientes tecnofuncionales, en productos de panificación sin gluten
Authors: Villegas-Ornelas Cinthia J. , Fregoso-Ultreras Mariana C. , Arce-Barrera Israel R. , Blancas Benitez Francisco Javier
Published: August 2024

El presente artículo muestra información relevante de los últimos años con respecto al uso de subproductos de frutos para la elaboración de harinas no convencionales y su empleo en formulaciones de productos de panificación sin harina de trigo. Las cuales pueden conservar distintos compuestos, como polisacáridos no digeribles (fibra dietética), macronutrientes (proteínas, lípidos, carbohidratos), así como compuestos antioxidantes (compuestos fenólicos). Los cuales pueden contribuir a mejorar las propiedades tecnofuncionales de la harina, afectando de manera positiva los parámetros de calidad del producto de panificación final. Este artículo describe de forma resumida, como se obtienen los subproductos de frutos, sus propiedades y su potencial uso en formulaciones de productos de panificación sin trigo o sin gluten.
Desafíos de la Mediación en un Contexto Multicultural en Países de Habla Hispana
Authors: Torres-García Elizabeth
Published: August 2024

La mediación es, en el siglo XXI, un elemento vital para la paz e indispensable en las comunidades mundiales. Nuestra actual dinámica social está inmersa en una vorágine de cambios estructurales, de informática, de nuevas formas de relaciones de las personas que no se limitan a establecer redes con sus cercanos físicamente, sea en la comunidad o en la región geográfica que reside. Rebasa fronteras y espacios tradicionales de interacción. El objetivo es identificar los desafíos de la mediación en un contexto multicultural, los mecanismos que se aplican y la efectividad que presentan en la gestión del conflicto. Para ello es preciso señalar que la multiculturalidad permite una integración de personas y comunidades sin que se atente al natural proceso de identidad de las culturas en determinados espacios geográficos. El diseño de investigación es deductivo-inductivo ya que conlleva un razonamiento lógico relacional; es aplicada puesto que pretende brindar respuestas a una situación concreta, con análisis de documentos como son leyes y teorías. Es descriptiva cualitativa por cuanto que recopila y procesa bibliografía, leyes y teorías de la naturaleza actual y la composición del fenómeno a investigar.
Los actores y la mirada subjetiva de la Organización Universitaria
Authors: Roque Nieto Nohemí , Pérez Mayo Augusto Renato
Published: August 2024

Las organizaciones, también, se construyen a partir de la palabra, de la narrativa, de esa interacción social que se da en la informalidad a la luz de la charla, de la toma de un café, en el pasillo, en la sala de maestros, en la sala de espera de la administración, entre otros escenarios; desvelando de alguna manera que la organización también es informal, que también es cotidiana, que los actores vierten en el espacio organizacional su comportamiento, su intersubjetividad producto de la convivencia práctica de su contexto, de su operatividad, de su dinámica social y su relación social en un contexto dado, histórico y culturalmente hablado, es decir, los núcleos de inteligibilidad que se toman y comunican a través de la práctica, la instrucción y la relación social (núcleo central).
Enseñanza experimental de la mecánica de fluidos mediante la V de Gowin como estrategia didáctica
Authors: Rojas Rojas Marco Alejandro , Guachún Lucero Freddy Patricio , Rivadeneira Loor Fredy Yunior
Published: August 2024

El estudio de la física es internacional y está presente en todos los currículos de nivel secundario y en una variedad de carreras universitarias. La importancia de esta asignatura radica en que la mayoría de las problemáticas del mundo real pueden ser solucionadas desde la física. Es por ello que se plantea la V de Gowin como estrategia didáctica para la enseñanza experimental de la Mecánica de fluidos en los estudiantes de la carrera de Pedagogía de las Ciencias Experimentales de la Universidad de Cuenca. En la investigación se utilizó una metodología cuasi experimental donde se manipula la variable independiente que es V de Gowin como estrategia educativa y se analiza la variable dependiente que es el rendimiento académico. El estudio tiene un enfoque cuantitativo y se llevó a cabo con un solo grupo experimental al que se le aplicó un pre test, seguidamente se realizó la implementación de la estrategia didáctica y posteriormente se aplicó el post test de conocimientos. Los resultados obtenidos muestran mejoría ante la estrategia didáctica, donde estadísticamente mediante la prueba T de Student se pudo corroborar la efectividad de la propuesta. Además de ver mejoría en el rendimiento académico se pudo apreciar la eficacia de la V de Gowin en el trabajo colaborativo donde los estudiantes compartieron experiencias y mediante la experimentación demostraron principios físicos.
INTEGRASI NILAI-NILAI MULTIKULTURAL DALAM KURIKULUM PENDIDIKAN AGAMA ISLAM UNTUK MEMBANGUN TOLERANSI DI SEKOLAH
Authors: Tentiasih Septyana , Rizal Rifa'i Muhammad
Published: August 2024

This study aims to examine the integration of multicultural values into the Islamic Religious Education (PAI) curriculum as a means of fostering tolerance in schools. The research employs a qualitative method with a library research approach, focusing on several schools in Indonesia that have implemented a multicultural-based PAI curriculum. The findings indicate that integrating multicultural values into PAI enhances students' understanding and tolerance toward religious and cultural diversity. The appropriate implementation of the curriculum, including the use of collaborative learning methods and relevant teaching materials, has proven effective in shaping students' inclusive character and appreciation for differences. However, the study also identifies several challenges, such as the lack of teacher training in delivering multicultural values and resistance to curriculum changes. Despite these challenges, the research highlights that integrating multicultural values into the PAI curriculum has significant potential to create a harmonious school environment and promote the development of a more tolerant society.
FAKTOR YANG BERHUBUNGAN DENGAN KUNJUNGAN POS PEMBINAAN TERPADU (POSBINDU) PENYAKIT TIDAK MENULAR DI KABUPATEN TULANG BAWANG BARAT TAHUN 2020
Authors: Maryati Maryati , Budiati Endang , Noviansyah Noviansyah
Published: August 2024

Background: The low visit of Posbindu PTM shows the low awareness of community about the importance of Posbindu PTM. It means there is a gap of Posbindu PTM services with the response of the community.  Purpose: to know the factors related to Posbindu PTM visit in Tulang Bawang Barat Regency in 2020. Methods: Type of research is quantitative with cross sectional approach. The population is the target of Posbindu (age>15 years) and adopted 439 samples. Data analysis using univariate analysis, bivariate (chi square) multivariate (multiple logistic regression). Results: there is a relationship between knowledge (p=0.000), attitude (p=0.000), education (p=0,000), income (p=0.004), accessibility (p=0.007) and support of health workers (p=0.000) with Posbindu PTM visit. Knowledge is the dominant factor related to Posbindu PTM visits (p = 0.000).Conclusion: Determinant of Posbindu PTM Visit are knowledge, attitude, education, income, accessibility and support of health workers with Posbindu PTM visit, that’s why this research perfecting Standard of operational procedure and disseminating information on hypertonic infusion fluid and monitoring it regularly and continuously.
PENGARUH E-SERVICE QUALITY, KESADARAN MEREK DAN KEPERCAYAAN PELANGGAN TERHADAP LOYALITAS PELANGGAN
Authors: Aswira Resfika , Kuswinton Kuswinton
Published: August 2024

ABSTRAK
Teknologi dan informasi berkembang pesat dalam beberapa tahun terakhir, seiring dengan meningkatnya kemudahan perkembangan internet, sehingga fungsi  internet tidak hanya untuk mencari informasi, tetapi juga untuk membeli secara online. Toko online menawarkan berbagai peluang untuk berbisnis dan menjalankan berbagai kampanye. Loyalitas pelanggan masih menarik untuk dipelajari karena masih banyak artikel di area ini. Saat ini tren transportasi online tidak hanya di kota-kota besar saja, Kota Baubau juga memiliki alat transportasi online bernama Kururio. Dengan bantuan transportasi online, diharapkan para pengemudi ojek dapat lebih mudah menawarkan jasanya tanpa harus berkeliling kota untuk mencari penumpang, maupun pelanggan untuk mencari transportasi yang mereka butuhkan. telah dilaksanakan sejak tahun 2018. Tujuan penelitian ini untuk Cari tahu bagaimana kualitas layanan elektronik mempengaruhi loyalitas pelanggan, untuk mengetahui pengaruh kesadaran merek terhadap loyalitas pelanggan, dan Cari tahu bagaimana kepercayaan pelanggan mempengaruhi loyalitas pelanggan. Metode yang digunakan dalam penelitian ini adalah regresi berganda. Hasil penelitian ini menunjukan bahwa E-service quality, kepercayaan pelanggan dan kesadaran merek berpengaruh positif dan signifikan terhadap loyalitas pelanggan Kururio Kota Baubau.
Kata Kunci: E-Service Quality, Kepercayaan pelanggan, Kesadaran Merek, dan Loyalitas pelanggan
 
ABSTRACT
Technology and information have developed rapidly in recent years, along with the ease of development of the internet, so that the function of the internet is not only to search for information, but also to buy online. Online shops offer various opportunities to do business and run various campaigns. Customer loyalty is still interesting to study because there are still many articles in this area. At present the online traffic trend is not only in big cities, Baubau City also has an online traffic tool called Kururio. With the help of online transportation, it is hoped that ojek drivers can more easily offer their services without having to go around town looking for passengers, as well as customers looking for the transportation they need. has been carried out since 2018. The purpose of this research is to find out how electronic service quality affects customer loyalty, to determine the effect of brand awareness on customer loyalty, and find out how customer trust affects customer loyalty. The method used in this study is multiple regression. The results of this study indicate that E-service quality, customer trust and brand awareness have a positive and significant effect on customer loyalty Kururio Baubau City.
Keywoards: E-Service Quality, Customer Trust, Brand Awareness, and Customer Loyalty