bluuebunny/crossref_metadata_2025 huggingface dataset:
Vascular medicine in the 21st century: Embracing comprehensive vasculature evaluation and multidisciplinary treatment
Authors: Chaiter Yoram , Fink Daniel Lyon , Machluf Yossy
Published: July 2024

The field of vascular medicine has undergone a profound transformation in the 21st century, transforming our approach to assessment and treatment. Atherosclerosis, a complex inflammatory disease that affects medium and large arteries, presents a major challenge for researchers and healthcare professionals. This condition, characterized by arterial plaque formation and narrowing, poses substantial challenges to vascular health at individual, national, and global scales. Its repercussions are far-reaching, with clinical outcomes including ischemic heart disease, ischemic stroke, and peripheral arterial disease—conditions with escalating global prevalence. Early detection of vascular changes caused by atherosclerosis is crucial in preventing these conditions, reducing morbidity, and averting mortality. This article underscored the imperative of adopting a holistic approach to grappling with the intricacies, trajectories, and ramifications of atherosclerosis. It stresses the need for a thorough evaluation of the vasculature and the implementation of a multidisciplinary treatment approach. By considering the entire vascular system, healthcare providers can explore avenues for prevention, early detection, and effective management of this condition, ultimately leading to improved patient outcomes. We discussed current practices and proposed new directions made possible by emerging diagnostic modalities and treatment strategies. Additionally, we considered healthcare expenditure, resource allocation, and the transformative potential of new innovative treatments and technologies.
Application effect of case management nursing based on patient safety in patients with prostate cancer
Authors: Zhou Ru , Xu Chan-Ling
Published: July 2024

BACKGROUND

Globally, prostate cancer has become a major threat to men's health, with an increasing incidence and causes serious effects on the quality and length of life of patients. Despite the rapid development of medical technology, which provides treatments, including surgery, radiotherapy, and endocrine therapy, the treatment of patients with prostate cancer, especially with endocrine therapy, has become a major challenge in clinical treatment owing to the lengthy course of treatment, side effects of drugs, and impact of the disease on the psychological and physiological functioning of the patient, producing poor treatment adherence and a decline in quality of life.

AIM

To explore effects of nursing intervention prioritizing patient safety and case management in patients with prostate cancer undergoing endocrine therapy.

METHODS

Eighty patients with prostate cancer who received endocrine therapy at our hospital between January 2022 and January 2024 were divided into observation and control groups with 40 cases per group. The control group was treated using a routine nursing workflow while the observation group received case management nursing guidance prioritizing patient safety. Scores for anxiety and depression, prostate cancer symptoms, and quality of life and patient compliance and satisfaction were compared between the groups after three months of intervention.

RESULTS

After the nursing intervention, the anxiety and depression scores of the observation group were significantly lower than those of the control group (P < 0.05). The quality of life score, sexual function, and hormone function were significantly higher than those in the control group (P < 0.05).

CONCLUSION

Case management guidance based on patient safety effectively reduced anxiety and depression in patients undergoing endocrine therapy for prostate cancer and improved their quality of life, treatment compliance, and satisfaction.
Successful endoscopic treatment of superficial esophageal cancer in a patient with esophageal variceal bleeding: A case report
Authors: Xu Li , Chen Shan-Shan , Yang Chao , Cao Hai-Jun
Published: July 2024

BACKGROUND

The coexistence of esophageal variceal bleeding and superficial esophageal cancer (SEC) is relatively rare in clinical practice. Moreover, there have been few reports of SEC overlying esophageal varices (EVs). Herein, we report our successful use of endoscopic submucosal dissection (ESD), esophageal solitary venous dilatation (ESVD), and endoscopic injection sclerotherapy (EIS) to treat a 75-year-old man who was diagnosed with SEC coexisting with esophageal variceal bleeding.

CASE SUMMARY

A 75-year-old man was admitted to the hospital due to black stool for 4 days. The patient had a history of liver cancer, cirrhosis, and portal hypertension. Endoscopic examination revealed esophageal and gastric varicose veins, as well as esophageal carcinoma in situ . We first treated esophageal variceal bleeding by ESVD and EIS. One week later, ESD treatment was done, and the complete resection of early esophageal cancer was successfully completed via endoscopy. There were no postoperative complications, such as bleeding, infection, or perforation.

CONCLUSION

The sequential treatment of ESVD, EIS, and ESD is an effective method for treating EVs with early esophageal cancer.
Emociones, uso problemático de Internet y exposición de la intimidad en redes sociales en jóvenes
Authors: Fernández-García Esther , Cava María-Jesús , Buelga Sofía , Carrascosa Laura
Published: July 2024

La exposición pública de la intimidad en redes sociales (extimidad) es frecuente entre los jóvenes, y podría estar asociada a las emociones que experimentan antes de conectarse y al uso problemático de Internet (uso adictivo, preferencia por interacción social online y uso para regular emociones). No obstante, estos vínculos apenas han sido investigados. Los objetivos de este estudio fueron analizar la prevalencia de diferentes emociones experimentadas por los jóvenes antes de conectarse a Internet, explorar sus correlaciones con el uso problemático de Internet y la extimidad, analizar posibles diferencias en emociones y uso problemático de Internet en función de una mayor o menor extimidad, y explorar la capacidad predictiva de las emociones y del uso problemático de Internet respecto a la extimidad. Participaron 312 jóvenes, entre 18 y 28 años (M = 21.22, DT = 2.45). Los resultados indicaron que la emoción más experimentada por los jóvenes antes de conectarse a Internet es el aburrimiento, si bien la prevalencia observada en emociones positivas, como alegría o ilusión, también fue considerable. Se constataron correlaciones significativas entre las emociones experimentadas antes de conectarse, el uso problemático de Internet y las conductas de extimidad. Los jóvenes con niveles altos de extimidad mostraron puntuaciones significativamente mayores en las emociones de aburrimiento, ilusión, estrés, alegría y felicidad, así como en uso adictivo de Internet y uso para regular su estado de ánimo. Las emociones de alegría, ilusión y aburrimiento, junto con el uso adictivo de Internet, fueron predictores significativos de la extimidad en los jóvenes.
Research About Us, With Us: An Inclusive Research Case Study
Authors: Buck Andrew S. , Chapman Richard , Krahn Gloria L. , Brown Christine , Gertz Braden , Havercamp Susan M. ,   The Ohio State University Nisonger RRTC on Health and Function
Published: July 2024

Inclusive research combines the expertise of academically trained researchers with the lived experience of individuals with disabilities to render results that are more accessible, accountable, and meaningful to the disability community. In this case study, adults with intellectual and developmental disabilities (IDD) contributed as co-researchers to a series of studies on mental health of adults with intellectual disability. The research model, specific engagement strategies, and lessons learned are shared. Feedback from members of the research team suggests that including adults with IDD as co-researchers benefited investigators, co-researchers with IDD, and project outcomes. Our case study emphasizes the valuable contributions of research partners with IDD and provides a model that may be adapted and utilized by researchers to enhance their practice.
Low crosstalk heterogeneous sixteen-core four-mode fiber with concave-convex double-type refractive index profiles
Authors: Shao Pengshuai , Li Shuguang , Li Jianshe , Cheng Tonglei , Zhang Lei
Published: July 2024

Multi-core few-mode fiber based on space division multiplexing technology is widely regarded as the primary solution to the optical communication capacity issue. However, the quality of the communication signal of the multi-core few-mode fiber depends on the degree of energy coupling between the cores. Thus, we propose a heterogeneous sixteen-core four-mode fiber that achieves low inter-core crosstalk, which first employs a combination of concave and convex double-type refractive index profiles. The advantage of this double-type refractive index profile is that the fiber can more conveniently regulate the phase differences of the same modes in adjacent cores. At the wavelength of 1550 nm and the optimal fiber parameters, all cores of the proposed fiber support four LP modes, and the inter-core crosstalk of all LP modes is less than -72 dB/km. This research demonstrates the efficacy of the proposed fiber in enhancing signal quality and presents innovative ideas and solutions for the future design of various low crosstalk multi-core few-mode fiber.
Single-pixel complex-amplitude imaging based on untrained complex-valued convolutional neural network
Authors: Liang Qi-Hang , Zhang Zi-Le , Wang Xu-Kai , Zhao Ya-Nan , Zhang Su-Heng
Published: July 2024

Single-pixel imaging is advancing rapidly in complex-amplitude imaging. However, reconstructing high-quality images demands significant acquisition and heavy computation, making the entire imaging process time-consuming. Here we propose what we believe to be a novel single-pixel complex-amplitude imaging (SCI) scheme using a complex-valued convolutional neural network for image reconstruction. The proposed sheme does not need to pre-train on any labeled data, and can quickly reconstruct high-quality complex-amplitude images with the randomly initialized network only under the constraints of the physical model. Simulation and experimental results show that the proposed scheme is effective and feasible, and can achieve a good balance between efficiency and quality. We believe that this work provides a new image reconstruction framework for SCI, and paves the way for its practical applications.
Spermatogenic cell-specific type 1 hexokinase (HK1S) is essential for capacitation-associated increase in tyrosine phosphorylation and male fertility in mice
Authors: Tian Yingchao , Chen Xiu , Pu Jie , Liang Yuxin , Li Weixi , Xu Xiaotong , Tan Xinshui , Yu Shuntai , Shao Tianyu , Ma Yan , Wang Bingwei , Chen Yongjie , Li Yushan
Published: July 2024

Hexokinase (HK) catalyzes the first irreversible rate-limiting step in glycolysis that converts glucose to glucose-6-phosphate. HK1 is ubiquitously expressed in the brain, erythrocytes, and other tissues where glycolysis serves as the major source of ATP production. Spermatogenic cell-specific type 1 hexokinase (HK1S) is expressed in sperm but its physiological role in male mice is still unknown. In this study, we generate Hk1s knockout mice using the CRISPR/Cas9 system to study the gene function in vivo. Hk1s mRNA is exclusively expressed in testes starting from postnatal day 18 and continuing to adulthood. HK1S protein is specifically localized in the outer surface of the sperm fibrous sheath (FS). Depletion of Hk1s leads to infertility in male mice and reduces sperm glycolytic pathway activity, yet they have normal motile parameters and ATP levels. In addition, by using in vitro fertilization (IVF), Hk1s deficient sperms are unable to fertilize cumulus-intact or cumulus-free oocytes, but can normally fertilize zona pellucida-free oocytes. Moreover, Hk1s deficiency impairs sperm migration into the oviduct, reduces acrosome reaction, and prevents capacitation-associated increases in tyrosine phosphorylation, which are probable causes of infertility. Taken together, our results reveal that HK1S plays a critical role in sperm function and male fertility in mice.
Thickness of the abdominal wall and pelvic floor dysfunctions in men who practice crossfit vs no crossfit: An observational study
Authors: Courtaut García Carla Isabel , Mateos Noblejas María , Romero Morales Carlos , Martínez Pascual Beatriz
Published: July 2024

Introduction

The objective of this study is to compare the thickness of the transverse abdominis, internal oblique, external oblique, rectus abdominis, and rectus abdominis distance, the quality of life (SF-36), the presence of chronic pelvic pain (CPPQ-Mohedo), and sexual dysfunction (IIEF) in men who practice CrossFit® versus men who do not.

Design, setting, participants, and main outcome measures

Sixty-four healthy men with an average age of 37.19 were recruited at a private sports club and divided into two groups for this cross-sectional observational study. Additionally, participants completed the CPPQ-M, IIEF, and SF-36 questionnaires.

Results

Significant differences were found in the thickness of the internal oblique at rest (p = 0.018, d = 0.61), which was greater in the CrossFit® group. In the SF-36 quality of life questionnaire (p = 0.05, d = 0.50), the CrossFit® group also obtained a higher score.

Conclusion

CrossFit® improves the quality of life and self-esteem of the participants, in addition to increasing the thickness of the internal oblique. Neither more chronic pelvic pain nor more erectile dysfunction was observed in the CrossFit® group.
Digital economy, resource distortion and low-carbon inclusive development-Evidence from the perspectives of a threshold effect and knowledge spillover effect
Authors: Yang Guoge , Deng Feng , Wang Fengyi , Mao Zhenyu , Wu Xingsheng , Zhang Fengyu
Published: July 2024

The low-carbon economy represents a global transformation that encompasses production methods, lifestyles, values, national interests, and the destiny of humanity. As a significant contributor to carbon emissions, China has made a momentous strategic decision on carbon peaking and neutralization, infusing momentum into the global effort to address climate change. The rapid growth of the digital economy offers a fresh approach to achieving the "double carbon" objective and advancing the development of low-carbon transformation. Based on the panel data of 30 provinces in China, this paper uses the least square method to investigate the impact of digital economy development on regional low-carbon inclusive development. It is found that there is a significant inverted U shape in the impact of the digital economy on low-carbon inclusive development and the mechanism is resource allocation and ecological inequality. The threshold test found that the role of the digital economy in promoting low-carbon inclusive development shows a marginal decreasing trend. The inverted U-shaped impact of the digital economy on low-carbon inclusive development in the eastern and coastal areas and areas with a low level of factor productivity is more significant. Based on the knowledge factor spillover perspective, we found that the impact of the digital economy on low-carbon inclusive development has a spatial spillover effect, and this effect is more obvious under the role of R&D personnel mobility.
Instruments for evaluating the parental emotional status and ecological support systems among parents who considered cochlear implantation for their children with hearing loss: A scoping review
Authors: Lim Tang Zhi , Umat Cila , Chen Pei-Hua , Gan Chun Hong , Goh Bee See
Published: July 2024

Objectives

Parents of children diagnosed with severe-to-profound sensorineural hearing loss may experience a range of emotions owing to a lack of knowledge and experience in dealing with such children. However, most audiology clinics only attend to children with deaf and hard of hearing (DHH) and not their parents. Thus, parents’ emotional and support needs are frequently excluded from the intervention sessions, making their own needs invisible. This study aimed to identify academic and clinical instruments used for assessing parental emotional status (PES) and ecological support systems (ESS) in early intervention and determine the factors affecting PES and ESS among parents of DHH children undergoing cochlear implantation.

Materials and methods

This scoping review followed the rigorous methodological framework; searched Medline (via OVID and EMBSCO), Scopus, and Web of Science; and selected studies relevant to validated instruments used to evaluate the PES and ESS among parents of DHH children below 6 years old. Before selecting and reviewing relevant articles, two reviewers independently assessed article titles and abstracts from the data sources. Two reviewers verified half of the first reviewer’s extracted data.

Results

Overall, 3060 articles were retrieved from the database search, and 139 were selected for full-text review following title and abstract reviews. Ultimately, this study included 22 articles. Among them, 23 and 12 validated instruments, most of which are generic measures, were used for assessing PES and ESS, respectively. Three condition-specific instruments were identified and designed to be administered following cochlear implantation surgery.

Conclusions

This study revealed that healthcare professionals who interact with parents of DHH children lack the necessary instruments, particularly for parents of children undergoing cochlear implantation surgery. Therefore, it is necessary to develop condition-specific instruments for parents who consider cochlear implantation for their children.
Improvements in hematologic markers and decreases in fatigue with pegcetacoplan for patients with paroxysmal nocturnal hemoglobinuria and mild or moderate anemia (hemoglobin ≥10 g/dL) who had received eculizumab or were naive to complement inhibitors
Authors: Panse Jens , Daguindau Nicolas , Okuyama Sonia , Peffault de Latour Régis , Schafhausen Philippe , Straetmans Nicole , Al-Adhami Mohammed , Persson Emmelie , Wong Raymond Siu Ming
Published: July 2024

Background

Although complement component 5 inhibitors (C5is) eculizumab and ravulizumab improve paroxysmal nocturnal hemoglobinuria (PNH) outcomes, patients may experience persistent anemia. This post hoc analysis investigated whether the complement component 3-targeted therapy pegcetacoplan also improved hematologic outcomes and reduced fatigue in patients with PNH and mild/moderate anemia.

Methods

Patients with PNH and hemoglobin ≥10.0 g/dL at baseline of PADDOCK (N = 6), PRINCE (N = 8), and PEGASUS (N = 11) were included. Before receiving pegcetacoplan, PADDOCK and PRINCE patients were C5i-naive; PEGASUS patients had hemoglobin <10.5 g/dL despite stably dosed eculizumab. Hemoglobin concentrations, percentages of patients with concentrations ≥12 g/dL, and sex-specific normalization were assessed at baseline and after 16 weeks of pegcetacoplan, as were absolute reticulocyte counts (ARCs) and normalization and fatigue scores and normalization.

Results

From baseline to week 16, mean (SD) hemoglobin concentrations increased in C5i-naive patients (PADDOCK: 10.5 [0.4] to 12.7 [1.1] g/dL; PRINCE: 11.3 [1.0] to 14.0 [1.3] g/dL) and those with suboptimal eculizumab responses (PEGASUS: 10.2 [0.2] to 12.8 [2.6] g/dL). Percentage of patients with hemoglobin ≥12 g/dL increased (PADDOCK: 0 to 60.0% [3 of 5 patients]; PRINCE: 25.0% [2 of 8] to 87.5% [7 of 8]; PEGASUS: 0 to 72.7% [8 of 11]). Sex-specific hemoglobin normalization at week 16 occurred in 40.0% (2 of 5) (PADDOCK), 62.5% (5 of 8) (PRINCE), and 63.6% (7 of 11) (PEGASUS). In all studies, mean ARCs decreased from above normal to normal and ARC normalization increased. Mean Functional Assessment of Chronic Illness Therapy–Fatigue scores improved from below to above or near normal. Two patients had serious adverse events (PEGASUS: post-surgery sepsis, breakthrough hemolysis); breakthrough hemolysis resolved without study discontinuation.

Conclusion

Patients with PNH and mild/moderate anemia who were C5i-naive or who had suboptimal hemoglobin concentrations despite eculizumab treatment had improved hematologic outcomes and reduced fatigue after initiating or switching to pegcetacoplan.

Trial registration

Trial registration numbers: PADDOCK (NCT02588833), PRINCE (NCT04085601; EudraCT, 2018-004220-11), PEGASUS (NCT03500549).
Evaluation of cooling effect and road performance of warm mixed high viscosity porous asphalt mixture
Authors: Lei Jun’an , Zheng Nanxiang , Jia Zhiyuan
Published: July 2024

In order to study the effect of different warm mixing agents on the cooling and road performance of porous mixture bonded with High Viscosity Asphalt (HVA), the Superpave Gyratory Compactor (SGC) was proposed to conduct variable temperature compaction test on the warm mixed porous asphalt mixture. The relationship between the compaction difficulty coefficient and the temperature of the mixture was obtained by regression, and the mixing and compacting temperature and cooling effect of the warm mixed porous asphalt mixture were determined. Then, the influence of Evotherm M1 and EC120 warm mix agents on the performance of porous asphalt mixture was compared by rutting tests, beam bending tests, immersion Marshall tests, freeze-thaw splitting tests, and penetration strength tests. The results show that two types of warm mixing agents can reduce the mixing and rolling temperatures of the mixture by more than 10°C. The addition of warm mix agents will increase the high temperature stability, water stability, and shear resistance of porous asphalt mixtures. For the improvement effect of high temperature stability, EC120 warm mixing agent is greater than Evotherm M1 warm mixing agent, and for the improvement effect of water stability, Evotherm M1 warm mixing agent is greater than EC120 warm mixing agent. For shear resistance, the improvement effect of both is equivalent, with a penetration strength increase of about 3% to 4%. For low temperature performance, Evotherm M1 warm mixing agent improved the low temperature performance, while EC120 warm mixing agent showed the opposite effect.
Status and influential factors of health literacy in patients with ischemic stroke: A cross-sectional study
Authors: Ouyang Weixiu , Wang Rui , He Yueyue , Song Yuqing , Mo Linqi , Feng Ling
Published: July 2024

Aim

The purpose of this study was to investigate the health literacy level and influencing factors of patients with ischemic stroke.

Design

A cross-sectional study was conducted.

Methods

We used convenient sampling to recruit potential participants. Patients with ischemic stroke who were hospitalized in the Department of Neurology, West China Hospital, Sichuan University in China from January 2022 to May 2023 were selected as subjects to complete the questionnaire survey. We used the National Institute of Health Stroke Scale to assess the neurological impairment of patients and the Health Literacy Scale for Chronic Patients to assess the health literacy level of patients.

Results

The overall health literacy level of ischemic stroke patients was high (99.13 ± 10.15). Age, education level, per capita monthly family income, living situations and National Institutes of Health Stroke Scale score were independent risk factors affecting the health literacy level of patients with ischemic stroke. Patients with a higher education level (β = 0.151, P = 0.006) and higher per capita monthly family income (β = 0.179, P = 0.001) had higher levels of health literacy. Patients who lived with their spouses (β = -0.117, P = 0.012) had higher health literacy. Patients at an older age (β = -0.151, P = 0.001) and patients with higher NIHSS scores (β = -0.450, P = 0.001) had lower health literacy levels.

Conclusions

Age, education level, family per capita monthly income, living situations and National Institute of Health Stroke Scale score were related to the health literacy level of patients with ischemic stroke. According to these associated factors, targeted health education should be developed to improve the health literacy of patients and health outcomes.
Biotic assemblages of gelatinous zooplankton in the Gulf of Mexico and adjacent waters: An evolutionary biogeographic approach
Authors: Ahuatzin-Hernández José María , Morrone Juan J. , Vidal-Martínez Víctor M.
Published: July 2024

Gelatinous zooplankton constitutes a polyphyletic group with a convergent evolutionary history and poorly known biogeographical patterns. In the Gulf of Mexico, a region with complex geological, hydrological, and biotic histories, the study of this group has been limited to taxonomical and ecological aspects. In this study, we implemented a track analysis to identify distributional patterns of gelatinous zooplankton in the Gulf of Mexico and adjacent waters based on a dataset of 6067 occurrence records corresponding to Hydrozoa, Scyphozoa, Cubozoa, Ctenophora, Chaetognatha, Thaliacea, and Appendicularia. Information was compiled from the Global Biodiversity Facility Information (GBIF) and Ocean Biodiversity Information System (OBIS) databases and peer-reviewed literature. Individual tracks were constructed by joining the minimum distance between the occurrence localities of each taxon using a minimum spanning tree algorithm. We identified generalized tracks using parsimony analysis of endemicity with progressive character elimination (PAE-PCE). The areas where different generalized tracks overlapped were considered to represent panbiogeographical nodes. Seven generalized tracks (two with nested patterns) and six panbiogeographical nodes were recognized, mainly in neritic zones. The distributional patterns of gelatinous zooplankton allowed us to identify four biogeographic areas, supporting previously proposed biogeographic schemes. Gelatinous zooplankton in the Gulf of Mexico showed a convergent spatial distribution that can be explained by vicariant and dispersal events. The historical biogeography of the gelatinous biotas of the Gulf of Mexico has been little studied compared to ecological approaches, and the lack of integrative studies considering historical patterns is evident. This type of research is fundamental to understanding the evolutionary history of natural resources from a spatial perspective, identifying sites of biodiversity and endemism, and establishing a biogeographic baseline of the region for further studies.
Fantasy through naturalism: Julia Trevelyan Oman and The Nutcracker
Authors: Maynard Elise
Published: July 2024

The Nutcracker is one of the most successful ballets in the world, accounting for almost half of the annual revenue of ballet companies across North America and Europe. As the third-largest ballet company in the world, the Royal Ballet’s version is one of the most recognizable, with designs created in 1984 by Julia Trevelyan Oman. Oman is the set and costume designer responsible for some of the longest continually running designs created for the Royal Opera House in London. Her method can be characterized as a highly detailed naturalism facilitated by meticulous research often centring on a period from history relating to the original conception of the narrative. Oman would use details gathered during her research process in order to build her theatrical worlds, in many instances creating high realism, and in others a complete immersive fantasy. The specific production of The Nutcracker serves as the epitome of Oman’s design practice, a perfect blend of her historical naturalism and detail-oriented fantasy. The production is praised for the design, yet Oman is largely neglected from the narrative around it. This article explores Oman’s design practice when working on The Nutcracker creating the splendour and success of London’s highest grossing ballet.
Farewell: Itineraries of the Wind: Building a scenic writing between the visible and the invisible
Authors: Rossin Elisa
Published: July 2024

This article presents the research behind the creation of the audio-visual work Farewell: Itineraries of the Wind, produced during the COVID-19 pandemic in 2021. Based on the fusion of life and art, this work develops in a hybrid territory between visual art, performance and cinema, and all the boundaries between these artistic languages become fluid. What stands out and is interesting to discuss in this process is the poetics of the materialities, ingrained in the costumes, sets, masks, puppets and their agency in the construction of sensorial and symbolic scenic writing. In Farewell: Itineraries of the Wind, these elements are handmade and carry meanings that are communicated both through their formal constitution (the visible) and their poetic aspects, the order of the invisible. They are used not only as decorative elements but also as means of subjectivation, transforming the atmosphere and establishing an affective relationship with the viewer, stimulating abstract fields of appreciation.
The Prague Quadrennial 2023 as a site for intergenerational opportunity
Authors: Scharf Julie
Published: July 2024

This ‘In Conversation’ essay arises from the opportunities for connection and ongoing collaboration during the international Prague Quadrennial 2023 (PQ23) Festival of Performance Design and Space, nurtured after the event on either side of the Atlantic. The text is based on the interviews held by the author with Czech costume designer Simona Rybáková focused on two performances attended by the author during the Prague Quadrennial 2023 programme: Eastern Bloc (an independent production presented at the performance space Divadlo X10) and A Bouquet (presented on the main stage of the National Theatre in Prague), both with costumes co-/designed by Rybáková. In the interview Rybáková shares some unique insights into her creative collaborative practice which is informed by both local contexts and international perspectives. This dialogic text represents the fruitfulness of interactions between emerging and established designers. The connection forged through the interview process is as relevant to intergenerational exchange as the interview itself and confirms the value offered to early career designers within the frame of international encounters.
Construção e Validação de Aplicativo como Tecnologia Educativa sobre a Avaliação das Doenças Diarreicas em Crianças na Atenção Primária
Authors: Batista Barbosa de Moura Maila , Astrês Fernandes Márcia , Galvão Gondim Corrêa Feitosa Lucíola , Ibiapina Tapety Fabrício , Macedo Joyce Lopes , Freitas de Carvalho Luiza Marly , De Carvalho e Martins Maria do Carmo
Published: July 2024

RESUMO
Objetivo: construir e validar um aplicativo móvel que funcione como tecnologia educativa sobre a avaliação das doenças diarreicas na infância pelos profissionais de saúde que atuam na atenção primária.para aprendizagem da avaliação das doenças diarreicas em crianças na atenção primária. Métodos: estudo metodológico desenvolvido em duas etapas: construção do aplicativo, norteada pelo Design Instrucional Contextualizado; e validação de conteúdo e de usabilidade com especialistas de saúde e de informática. Resultados: A validação de conteúdo e de usabilidade do aplicativo foi realizada por 30 juízes. Os itens foram avaliados com concordância superior a 80%. O IVC global atingiu 0,97. Não foram encontrados na literatura outros aplicativos ou ferramentas tecnológicas voltadas para a aprendizagem da avaliação das doenças diarreicas na infância. Conclusão: o aplicativo móvel desenvolvido reúne funções de acesso à informações e auxílio ao diagnóstico clínico das doenças diarreicas na infância. O estudo realizado poderá servir de subsídio para futuras pesquisas que proponham a capacitação dos profissionais atuantes na atenção primária.
 
Descritores: Diarreia infantil. Atenção Primária à Saúde. Materiais de ensino. Educação em saúde. Tecnologia da Informação.
Analysis of the effect of return on assets and return on equity on stock prices pt. (Persero) Mandiri bank TBK
Authors: Sulaiman Sulaiman
Published: July 2024

The capital market is a means of corporate finance through which companies obtain capital from investors. The main objective of investors who buy shares is to obtain dividends from the difference between the sale price and the purchase price of the shares. The share price is the price per share of the company issued on the stock exchange. This study aims to examine the relationship between return on assets and return on equity at PT. (PERSERO) MANDIRI Tbk. During the period 2019-2021. The purpose of this research is to discover and analyze the effect of return on assets and return on equity on stock prices at PT. (PERSERO) Mandiri BankTbk. The research method used is descriptive and quantitative methods. The analytical tool used is multiple linear regression and the coefficient of determination. Based on the results of the study, there is no effect (H0 is accepted) of return on assets (ROA) and return on equity (ROE) on stock prices.
The Contribution of the Tandem App on Tourism Undergraduates’ Speaking Fluency in English
Authors: Agurto Miguel , Cisterna Cecilia , Parra Jeanette
Published: July 2024

Speaking English fluently in social and professional settings has become a major requirement in the Tourism industry. With this in mind, this action research study explores how the Tandem application supports the speaking fluency of Tourism students in English. The study’s sample was comprised of seven participants from a Chilean professional institute who took part in four weekly online intervention sessions. Participants used the Tandem app to communicate with native and non-native speakers of English through voice messages during and after the intervention sessions. Their oral fluency was assessed by contrasting their speech rate and use of long pauses during a pre-and a post-session English fluency interview. Additionally, participants´ perceptions were collected through a semi-structured interview conducted in Spanish. Findings revealed that there was a slight, but nonetheless statistically significant in accordance with the Wilcoxon test, improvement in the fluency of their speaking. Participants agreed that the use of the application as a tool was beneficial and helped them to increase their speaking fluency and confidence by interacting with native and non-native speakers of English.
Learning Strategies Instruction: A Proposal for Encouraging Autonomous Learners
Authors: Hernández Gaviria Fanny , Ramirez Alexander
Published: July 2024

This reflective paper aims at disseminating a proposal for instruction to promote learning strategies in the foreign language classroom. The proposal was constructed based on the results of two action-research projects conducted at the Foreign Language Teacher Education Program (English – French) at Universidad del Valle, in Cali, Colombia. The results of these projects suggest that the implementation of learning strategies requires a specific sequence to develop learner autonomy and that finding the right dosage of strategies to cover in a course is paramount for their successful acquisition and implementation. Thus, the authors propose an adaptable instruction model that considers the findings of their research experiences. In this paper, the authors claim that while some strategies can be developed spontaneously throughout the learning process, some other strategies are more difficult to grasp, and therefore they require explicit instruction in just the right amount.
Polacy promowani na uniwersytecie w Perugii w XVI i XVII wieku
Authors: Chachaj Marian
Published: July 2024

The text presents the results of research carried out mainly in the files kept at the Archivio Storico degli Università degli Studi di Perugia. As a result, it was possible to establish that between 1575 and 1682, 39 Poles obtained 40 doctorates from the University of Perugia (Piotr Odorowski obtained two doctorates, in law and theology): 33 promotions were in law, two in canon law, and five in theology.Some of the degrees were awarded to individuals who had not studied longer in Perugia, and should be treated as honorary titles (Stanisław Reszka being a case in point). Prior to receiving their degrees in Perugia, most graduates studied at other universities: the largest number, at least 23, in Krakow; a few at the Vilnius Academy. Some studied at Jesuit colleges in Braniewo, Kalisz or Poznań. Single individuals took up studies at the universities of Frankfurt (Oder), Ingolstadt and Würzburg, and at the academy in Olomouc. For obvious raasons, most people studied in Italy (mainly in Rome and Padua) .Among those promoted, a large group were Catholic diocesan clergy; promotions of monks were rare (only two graduates were Discalced Carmelites). There were 24 graduates – representatives of the nobility, and 13 of the bourgeoisie; in two cases it was not possible to establish their social origin. Finally, let me stress the great importance of Perugia doctorates for the careers of the individuals promoted. Unfortunately, in most cases, the names of the professors whose lectures were listened to by newcomers from Poland remain unknown
P.Lund I 4 + P. Carlsb. inv. 50 ricongiunti. Frammenti di commedia adespota (PCG VIII 1066 + 1124)
Authors: Carlesimo Roberta
Published: July 2024

P.Lund I 4, first published in 1935, contains lines from an unknown comedy, doubtfully attributed to Menander in the ed.pr.; P. Carlsb. inv. 50, published in 1977, preserves verses from a comedy possibly by Menander or Apollodorus of Carystus. According to my re-examination, the two fragments belong to the same bookroll. In this paper I will discuss this joint, together with a new reconstruction of the comedy scene preserved by P.Lund I 4 and some new readings.
A Late Ptolemaic Order to Distribute One-Choinix Bread Loaves (P.Freib. 77)
Authors: Gerardin François
Published: July 2024

The late Ptolemaic document from the Freiburg papyrus collection published here for the first time is an order to distribute bread loaves. Fully preserved, it is of particular interest for its lexicographical novelties, such as the hitherto unattested adjective χοινικιεῖος. The article further discusses the origin, nature, and use of ὁλοπυρῖται ἄρτοι, “loaves of unground wheat,” and corrects editions of papyri mentioning ἄρτοι χοινικαῖοι (CPR I 31, P.Duke inv. 85 and P.Oxy. XXIV 2424 descr.).
Il problema di calcolo di interessi di SB XXIV 16038 A: errori di tradizione?
Authors: Savio Martina
Published: July 2024

The ‘mistakes’ in the arithmetical problem of SB XXIV 16038 A turn out to be most likely explained not as calculation mistakes but as errors occurred in a copying process, both considered in themselves and in the light of the transmission tendencies that can be detected in the papyrological tradition of this kind of mathematical texts. These errors appear to be strictly analogous or maybe in some way connected with the similar inconsistencies that affect the text of the closest parallel, namely, two loan problems of P.Mich. III 145 fr. 3 col. vii.1-4 (probl. 1) and 5-7 (probl. 2).
Abbreviations in Late Documents Resolved (III)
Authors: Gonis Nikolaos
Published: July 2024

Notes on the elucidation of passages in texts from late antiquity obscured by the use of abbreviations and editorial misses, continued from APF 68 (2022) 336-43.
“You Are the Pillar of Light That Supports the Whole World”: A Letter to Pesynthios of Koptos, Late Antique Concepts of a “Pillar of Light” and New Evidence for the Christian Redaction of the History of the Captivity in Babylon
Authors: Krueger Frederic
Published: July 2024

This article provides the join and re-edition of two previously edited Coptic ostraca which can now be identified as another letter to the famous 7th-century Egyptian bishop Pesynthios of Koptos, found like the rest of his correspondence at the Monastery of Epiphanius in Western Thebes. It is outstanding in its use of hagiographical language even within an archive notorious for such tendencies. In particular, the article explores the enigmatic title and theological concept “Pillar of Light.”
Baculovirus-mediated endostatin and angiostatin activation of autophagy through the AMPK/AKT/mTOR pathway inhibits angiogenesis in hepatocellular carcinoma
Authors: Wei Tingting , Cheng Jiajie , Ji Yonggan , Cao Xue , Ding Shuqin , Liu Quanxia , Wang Zhisheng
Published: July 2024

Hepatocellular carcinoma (HCC) is a highly vascularized carcinoma, and targeting its neovascularization represents an effective therapeutic approach. Our previous study demonstrated that the baculovirus-mediated endostatin and angiostatin fusion protein (BDS-hEA) effectively inhibits the angiogenesis of vascular endothelial cells and the growth of HCC tumors. However, the mechanism underlying its anti-angiogenic effect remains unclear. Increasing evidence suggests that autophagy has a significant impact on the function of vascular endothelial cells and response to cancer therapy. Hence, the objective of this research was to investigate the correlation between BDS-hEA-induced angiogenesis inhibition and autophagy, along with potential regulatory mechanisms. Our results demonstrated that BDS-hEA induced autophagy in EA.hy926 cells, as evidenced by the increasing number of autophagosomes and reactive oxygen species, accompanied by an upregulation of Beclin-1, LC3-II/LC3-I, and p62 protein expression. Suppression of autophagy using 3-methyladenine attenuated the functions of BDS-hEA-induced EA.hy926 cells, including the viability, proliferation, invasion, migration, and angiogenesis. Moreover, BDS-hEA induced autophagy by downregulating the expression of CD31, VEGF, and VEGFR2, as well as phosphorylated protein kinase B (p-AKT) and phosphorylated mammalian target of rapamycin (p-mTOR), while concurrently upregulating phosphorylated AMP-activated protein kinase (p-AMPK). The in vivo results further indicated that inhibition of autophagy by chloroquine significantly impeded the ability of BDS-hEA to suppress HCC tumor growth in mice. Mechanistically, BDS-hEA prominently facilitated autophagic apoptosis in tumor tissues and decreased the levels of ki67, CD31, VEGF, MMP-9, p-AKT, and p-mTOR while simultaneously enhancing the p-AMPK expression. In conclusion, our findings suggest that BDS-hEA induces autophagy as a cytotoxic response by modulating the AMPK/AKT/mTOR signaling pathway, thereby exerting anti-angiogenic effects against HCC.
Optimization of ECR assisted pre-ionization in GLAST-III via Multiphysics simulation
Authors: Shakir Sehrish , Khan Riaz , Ali Ahmad , Khan Shahab Uddin , Rehman Zia Ur , Qayyum Abdul , Abdullah Muhammad , Zahid Shahzaib , Kamran Muhammad
Published: July 2024

Electron cyclotron resonance (ECR) is a common pre-ionization technique to assist ohmic startup in tokamaks. In this research, ECR assisted pre-ionization in GLAST-III tokamak is comprehensively investigated via Multiphysics 3D COMSOL simulations. Optimal conditions for ECR microwave absorption at fundamental mode are determined to achieve reliable plasma startup. The effect of filled gas pressure on the ECR plasma parameters such as plasma density and plasma temperature is thoroughly investigated in the range of 0.08–1 Pa. The results reveal that the ECR absorption of the incident microwaves is significantly enhanced at low enough filled argon pressure. The behavior of absorbed microwave power is significantly changed for different filled gas pressures. In case of high gas pressure, the microwave power is deposited locally in front of the waveguide, whereas in case of low pressure (0.08 Pa), the microwave power is uniformly deposited along the resonance layer. Moreover, the experimental investigation extends to nearly identical operating conditions, confirming the ECR absorption. The experimental data aligns with the simulation results, collectively affirming the efficacy of optimized pre-ionization in the low gas pressure scenario (0.08 Pa) within the GLAST-III tokamak.
Methodology for analyzing dose consequence using atmospheric dispersion code A2CDOSE
Authors: Chiang Yu , Lu Chung-hsin , Teng Jen-hsin , Wang Jong-Rong , Chen Shao-Shuan , Chen Shao-Wen
Published: July 2024

The experience of Fukushima brings out the importance of the emergency response plan during or after a severe nuclear power plant (NPP) accident. To deal with the accident emergency response situation, the National Atomic Research Institute (NARI) in Taiwan developed an emergent radiological dose evaluation system with the Central Weather Administration (CWA) called “A2CDOSE”. A2CDOSE can evaluate the eight-day projected dose after a nuclear accident and provide the predicted dose consequences for decision-making. Nevertheless, a source term generation method was still needed during the accident. This study chose MELCOR as the comparison target for the source term simulation issue with RASCAL. A MELCOR calculation of Maanshan NPP was built and a 5 % containment leakage was set for both MELCOR and RASCAL source term calculations. It seems the calculations of noble gases were consistent between MELCOR and RASCAL. However, the Cs-137 and I-131 calculated by MELCOR were twice compared to the RASCAL results, which may have a chance to cause different calculations of public protective actions during an accident. After the source term analysis, several atmospheric dispersion cases were simulated by A2CDOSE and RASCAL for further comparison.
Integrating bulk-RNA and single-cell analysis reveals heterogeneous expression of cuproptosis-related sorafenib-resistant genes in hepatocellular carcinoma
Authors: Yu Ziqian , Song Linnan , Wang Yuhao , Chen Xinhui , Chen Peng , Zhong Shihong , Li Yongyin , Tang Libo
Published: July 2024

Objectives

Cuproptosis represents the copper-dependent novel cell death pattern. However, the effects of cuproptosis-related sorafenib-resistant genes on prognosis, treatment response, and sorafenib resistance in hepatocellular carcinoma (HCC) patients are still unclear. The present work aims to develop a cuproptosis-related signature for predicting HCC prognosis.

Methods

Cuproptosis-related sorafenib-resistant differentially expressed genes (CRSRDEGs) were identified by correlation analysis between cuproptosis genes and sorafenib-resistant genes using electronic databases TCGA and GEO. Besides, the cuproptosis-related sorafenib-resistant risk score model (CRSRRSM) was established through LASSO and univariate Cox regression analyses. Later, this model was adopted for analyzing HCC patient prognosis. Certain potential drugs and treatment sensitivity were also analyzed in HCC patients receiving sorafenib or transarterial chemoembolization (TACE) treatment.

Results

The CRSRRSM achieved excellent efficiency in predicting the prognosis and sorafenib or TACE treatment response of HCC patients. As revealed by somatic mutational analyses, CRSRRSM was associated with tumor mutational burden (TMB), especially for TP53, CSMD3, and OBSCN mutations. According to functional enrichment analysis, CRSRRSM was closely correlated with tumor-related pathways, cuproptosis-related tricarboxylic acid (TCA) cycle, and drug resistance. Notably, potential drugs such as sepantronium bromide, AZD8055, and RO-3306, the promising alternatives for treating HCC patients with sorafenib resistance, were also proposed based on CRSRRSM. Furthermore, single-cell transcriptomic analysis revealed that high-risk malignant cells demonstrated an increased capacity of proliferation and immune evasion.

Conclusions

A model, designated CRSRRSM, was constructed that can effectively predict the prognosis, sorafenib treatment response, and potential drugs for sorafenib resistance in HCC patients. This model provides potential implications for clinical management of HCC patients with sorafenib resistance.