bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluasi Sistem Informasi Kesehatan Kabupaten/Kota Di Puskesmas II Denpasar Barat Menggunakan Metode HOT FIT
Authors: Nilawati Ni Putu Intan
Published: October 2022

Penyelenggaraan evaluasi SIK dapat menajdi salah satu landasan dalam meningkatkan kualitas pelayanan kesehatan masyarakat. Penelitian ini bertujuan untuk  mengetahui  gambaran  SIK  Kabupaten/Kota  di  Puskesmas  II  Denpasar Barat. Desain penelitian observasional deskriptif kuantitatif dilakukan untuk pengembangan  SIK  Kabupaten/Kota  di  Puskesmas  II Denpasar  Barat.  Subjek pada  penelitian  adalah  seluruh  petugas  yang  mengoperasikan  SIK Kabupaten/Kota yang mengoperasikan 18 orang. Data dikumpulkan dengan kuesioner terstruktur yang diisi secara mandiri oleh responden. Analisis data dilakukan dengan menilai masing-masing komponen HOT FIT secara deskriptif yang disajikan dengan tabel dan narasi. Hasil pembahasan penelitian evaluasi Human diketahui memiliki nilai 3,14 dengan kategori “baik”. Evaluasi Organization didapatkan 2,83 dengan kategori “sedang”. Evaluasi komponen technology didapatkan nilai sebesar 2,92 dengan kategori “baik”. Evaluasi Net Benefit terhadap SIK Kabupaten/Kota didapatkan nilai 2,9 dengan kategori “baik”. Simpulan dari penelitian diketahui keberhasilan evaluasi SIK Kabupaten/Kota terdapat pada komponen Human, Technology, dan Net Benefit sedangkan  nilai  dalam  kategori rendah ada  pada  komponen  Organization.
Evaluasi Sistem Informasi Pengelolaan Persediaan Obat Di Apotek Indobat Pedungan
Authors: Maharani Retno Amelia
Published: October 2022

Salah satu pentingnya evaluasi sistem adalah mengurangi kehilangan data dalam sistem yang dapat menyebabkan kerugian serta meningkatkan kontrol dalam sistem untuk meminimalisir kesalahan. Di Apotek Indobat Pedungan belum pernah melakukan evaluasi tentang sistem informasi pengelolaan obat. Tujuan dari penelitian ini adalah untuk mengevaluasi sistem informasi pengelolaan persediaan obat di Apotek Indobat Pedungan Dengan Metode HOT Fit.Jenis penelitian ini adalah deskriptif kualitatif dengan metode wawancara mendalam menggunakan pedoman wawancara yang dikembangkan dari metode HOT Fit. Sampel pada penelitian ini adalah seluruh petugas apotek Indobat Pedungan yaitu petugas apoteker, petugas IT dan petugas gudang farmasi. Analisis data dalam penelitian ini menggunakan pendekatan kualitatif dengan teknik analisis tematik (thematic analysis).Hasil penelitian ini menunjukan bahwa sistem informasi pengelolaan persediaan obat di apotek Indobat Pedungan sudah cukup baik mulai dari faktor sumber daya manusia (Human) semua petugas sudah memahami isi dan fungsi sistem informasi pengelolaan persediaan obat, dari faktor organisasi (Organization) sudah cukup baik dan mampu menjalani dengan sebaik-baiknya sehingga petugas dapat mengerjakan tugas sesuai dengan struktur organisasi yang ada, dari faktor teknologi (Technology) cukup baik meskipun terdapat beberapa data atau fitur yang harus diperbaiki demi kesempurnaan sistem di apotek, dan dari faktor manfaat (Net Benefit) sistem informasi pengelolaan persediaan obat di apotek Indobat Pedungan memiliki pengaruh positif terhadap penggunaan sistem dan kepuasan pengguna.Dapat disimpulkan bahwa evaluasi sistem informasi pengelolaan persediaan obat di apotek Indobat Pedungan sudah cukup baik dan sudah sesuai dengan metode HOT Fit.
Faktor-Faktor Kelengkapan Informed Consent Menggunakan Metode Fishbone Untuk Menunjang Mutu Rekam Medis
Authors: Rizkika Sylda Namara , Sugiarti Ida
Published: October 2022

Ketidaklengkapan informed consent berdampak kepada kualitas mutu rekam medis. Penilaian kelengkapan informed consent dilakukan melalui analisis kuantitatif. Faktor kelengkapan informed consent dapat dianalisis menggunakan unsur manajemen. Penelitian dilakukan untuk menemukan faktor kelengkapan informed consent menggunakan unsur 5M dan metode fishbone. Jenis penelitian menggunakan metode literature review dari 16 jurnal menggunakan data sekunder dalam database Google Scholar dan strategi pencarian Kelengkapan OR Ketidaklengkapan OR Kuantitatif AND Informed Consent OR Persetujuan Tindakan Kedokteran NOT Rekam Medis dengan rentang waktu 2015-2020. Rata-rata kelengkapan informed consent 63%. Faktor kelengkapan informed consent berdasarkan literature yang dianalisis yaitu man (koordinasi petugas, kelalaian petugas, kesadaran petugas, kehadiran dokter, pemberian informasi, SDM, informed consent lisan dianggap mudah, pengetahuan, ketergantungan dokter, perhatian dokter, sikap dokter, kepatuhan, kesibukan, kondisi pasien), methods (penyelenggaraan rekam medis, keterkaitan SPO, prioritas pasien BPJS dan resiko tinggi, sosialisasi, evaluasi, tindak lanjut, akreditasi), materials (ketersediaan label, keterbacaan, ketersediaan bagian, bahasa dan kalimat, ketersediaan formulir), media (waktu, tempat), motivasi (punishment, reward).
Bagaimana Pemanfaatan Sertifikat Pelatihan Pengelolaan Sistem Pembiayaan Kesehatan Berbasis Casemix Oleh Rumah Sakit
Authors: Garmelia Elise , Susanto Edy - , Susanto Edy - , Windari Adhani , Windari Adhani , Fadhilah Isnaini Qoriatul , Fadhilah Isnaini Qoriatul
Published: October 2022

Sertifikasi biasanya diberikan oleh organisasi atau asosiasi profesi yang mengetahui dengan pasti suatu kompetensi profesional dalam bidang tertentu seperti Rekam Medis dan Informasi Kesehatan khususnya system pembiayaan terkait dengan kompetensi kodefikasi klinis. Tujuan Penelitian ini adalah untuk mengetahui Bagaimana Pemanfaatan Sertifikat Pelatihan Pengelolaan Sistem Pembiayan Kesehaan Berbasis Casemix oleh Rumah Sakit.  Metode penelitian populasi dan sampel adalah lulusan diploma 3 RMIK Polkesmar (regular)  tahun 2014-2019 sejumlah 265 dengan sampel 80 lulusan. Dilakukan uji validitas dan realibilitas kuesioner. Uji Statistik deskriptif dan korelasi. Hasil penelitian bahwa Pada Uji Regresi Anova, terdapat pengaruh yang signifikan p= 0.041 antara lulusan polkesmar kompetensi pelatihan system pembiayaan yang telah diberikan. Ada hubungan yang significan  (p=0.009) antara Diterimanya lulusan kurang dari 6 bulan dengan  Pekerjaan dan kompetensi pelatihan system pembiayaan yang telah diberikan seperti :  kemampuan melakukan koordinasi dengan Profesional Pemberi Asuhan (PPA)/Dokter Penanggung Jawab Pasien (DPJP ). Terdapat pengaruh yang signifikan (p= 0.023) antara lulusan yang bekerja kurang dari 6 bulan  dengan kompetensi pelatihan system pembiayaan yang telah diberikan. Kesimpulan bahwa adanya sertifikat pelatihan sistem pembiayaan berbasis casemix yang diadakan oleh Jurusan D3 RMIK Polkesmar, dapat bermanfaat untuk diterapkan di RS dan target yang akan dicapai oleh  para lulusan dalam mencari pekerjaan. Hal ini juga menjadi kesempatan ketika para lulusan ditempatkan sebagai karyawan yang sesuai dengan ketrampilan dan kompetensi yang sudah bersertifikat pelatihan system pembiayaan berbasis casemix di  Rumah Sakit.
Pengukuran Kinerja dengan Metode Human Resource Scorecard pada Petugas Rekam Medis di Salah Satu Rumah Sakit Daerah Kabupaten Lumajang
Authors: Erawantini Feby , Dwi Saraswati Galuh
Published: October 2022

Abstrak ditulis dalam bahasa indonesia masing-masing tidak lebih dari 200 kata yang mencakup atau terdiri dari masalah, tujuan, metode, dan hasil yang dituliskan dalam satu paragaraf, dituliskan dengan font Times New Roman ukuran 10pt spasi 1. Abstrak tidak perlu menyertakan sumber sitasi dan tidak boleh mengandung gambar dan tabel. Abstrak harus menggambarkan isi dari penelitian secara keseluruhan Pengukuran kinerja dapat diterapkan untuk mengetahui sejauh mana kualitas ketenagakerjaan. Penilaian kinerja petugas Unit Kerja Rekam Medis (UKRM) salah satu rumah sakit umum di Kabupaten Lumajang melalui observasi, pencapaian Standar Pelayanan Minimal (SPM) serta berdasarkan Standar Kinerja Pegawai (SKP). Sedangkan petugas ditemukan sering terlamat ketika masuk kerja. Tujuan penelitian ini adalah Melakukan Pengukuran Kinerja Seimbang dengan Metode Human Resource Scorecard Pada Petugas Rekam Medis di salah satu rumah sakit umum di Kabupaten Lumajang. Penelitian ini menggunakan metode deskriptif kuntitatif. Populasi yang digunakan adalah 27 petugas rekam medis dengan sample memakai total sampling. Berdasarkan hasil penelitian yang dilakukan dengan distribusi frekuensi, didapatkan nilai High Performance Work System (HPWS) baik (79%), HR Deliverable baik (83%), Efisiensi SDM baik (80%), Kinerja baik (86,31%). Sedangkan hasil pengukuran kinerja HR Scorecard pada petugas rekam medis yaitu proporsional,  dengan rata-rata skor  dimensi HR Scorecard 80,67% (baik) dan kinerja 76,15% (baik). Sehingga perlu adanya perhatian terhadap  sistem  reward maupun punishment, pengembangan profesional SDM, sistem presensi secara digital, monitoring dan evaluasi pelaksanaan poin HR Scorecard yang dominan dan kinerja.
Platform Informatika Kesehatan Masyarakat Dalam Kasus COVID-19 di Bali
Authors: Adiputra Mahayasa , Mulana Alfred , Farmani Ika
Published: October 2022

Pandemi COVID-19 telah menjadi masalah global dunia. Bali sebagai destinasi wisata dunia pun terkena dampak yang cukup memprihatinkan oleh karena laju penularan yang demikian cepat. Sinergi antara kajian kesehatan masyarakat dan teknologi informasi dalam informatika kesehatan masyarakat niscaya dapat berperan efektif dan efisien dalam mengerem laju penularan COVID-19. Penelitian kami bertujuan untuk memberikan informasi terkait COVID-19 yang terintegrasi dari seluruh kabupaten di Bali kepada masyarakat umum dengan tujuan untuk peningkatan kewapadaan serta kemudahan dalam membaca data. Selain itu, penelitian ini juga bertujuan menghasilkan platform yang dapat digunakan sebagai rujukan pengambilan keputusan dalam intervensi COVID-19 berbasis kesehatan masyarakat. Metode pengembangan perangkat lunak dalam penelitian ini adalah pengembangan platform berupa website, menggunakan metode rapid development dimana metode ini merupakan pengembangan yang dapat menyelesaikan platform dalam waktu singkat dengan tim yang sedikit, dengan project scope yang sudah jelas yaitu menggabungkan data – data COVID-19. Hasil penelitian ini adalah platform berbentuk situs web yang dapat diakses online di www.balisiagacorona.com. Situs Web terdiri dari Halaman Dashboard, Halaman Analitik dan Halaman Kontak. Informatika kesehatan masyarakat dapat berkontribusi memperlambat laju penularan COVID-19. Salah satu bentuk pengembangannya adalah platform digital dengan menggunakan teknologi website. Penelitian ini mengambil kasus COVID-19 di Bali, data diambil dari sumber - sumber tercepaya yaitu website resmi pemerintah di lingkungan provinsi bali dalam penanganan COVID-19.
Evaluasi Sistem Penyelenggaraan Rekam Medis Di Rumah Sakit Dharma Kerti
Authors: Kartika Dewi Ni Made Umi , Farmani Putu Ika
Published: October 2022

Penyelenggaraan rekam medis merupakan salah hal penting untuk menentukan kualitas pelayanan kesehatan terutama pada saat akreditasi. Penyelenggaraan rekam medis di Rs. Dharma Kerti menunjukkan beberapa permasalahan seperti pengisian rekam medis yang kurang lengkap, misfile serta rekam medis ganda. Tujuan dari penelitian ini untuk mengevaluasi penyelenggaraan rekam medis di Rs. Dharma Kerti. Penelitian ini adalah penelitian evaluasi deskriptif menggunakan pendekatan metode kualitatif. Pengumpulan informasi dilakukan dengan cara wawancara mendalam menggunakan lima informan dan metode purposive sampling. Hasil ditemukan bahwa beberapa input yang belum optimal seperti kurangnya kuantitas dan kualitas SDM, sarana prasarana yang belum ideal serta SOP yang tidak tersosialisasi. Hasil evaluasi pada proses penyelenggaraan rekam medis juga diperoleh kegiatan pengelolaan rekam medis yang kurang maksimal seperti pemberian nomor rekam medis baru kepada pasien lama, belum memiliki acuan ketat dalam pemberian nama, petugas rekam medis hanya melakukan filling rekam medis serta belum melakukan pemusnahan rekam medis yang sudah tidak aktif. Saran bagi rumah sakit untuk mengoptimalkan seluruh input dan bagi petugas di unit rekam medis agar melakukan seluruh proses pengelolaan rekam medis.
Analisis Kesiapan Implementasi Rekam Medis Elektronik dengan Pendekatan DOQ-IT (Doctor’s Office Quality-Information Technology)
Authors: Faida Eka Wilda , Ali Amir
Published: October 2022

Rumah Sakit Haji Surabaya dalam memberikan pelayanan terkait rekam medis masih belum memenuhi standar capaian yang ditentukan, dimana standar waktu penyediaan dokumen rekam medik rawat jalan yang seharusnya ≤ 20 menit masih mencapai standar 23,58 %, standar waktu penyediaan dokumen rekam medik pelayanan rawat inap yang seharusnya ≤ 15 menit masih mencapai standar 49,32%, waktu pelayanan surat keterangan medis yang seharusnya ≤ 2 hari masih mencapai standar 95,14%, Kelengkapan dokumen medis rawat inap masih mencapai 81,20% dan Pengembalian dokumen medis rawat inap 2x24 masih mencapai 80,9%. Hal ini merupakan indikator pelayanan yang kurang baik, melalui RME (Rekam Medis Elektronik) diharapkan dapat meminimalisir keterlambatan pengiriman data pasien. Agar masalah tidak menjadi berlarut maka perlu analisis kesiapan implementasi RME di rumah sakit. Tujuan penelitian ini adalah menganalisis kesiapan implementasi RME dengan pendekatan DOQIT (Doctor’s Office Quality-Information Technology) di RS Haji Surabaya. Penelitian ini dengan menggunakan jenis penelitian deskriptif kuantitatif dengan pendekatan cross sectional. Berdasarkan hasil penelitian yang telah dilakukan, maka dapat diperoleh informasi bahwa pada aspek sumber daya manusia, budaya kerja organisasi, tata kelola kepemimpinan, dan infrastruktur secara keseluruhan memiliki kategori sangat siap.Kata Kunci : Kesiapan, Rekam Medis Elektronik,  DOQIT
Tinjauan Efektivitas Kerja Penanggung Jawab Rekam Medis (PJRM) di Bangsal Perawatan Sesuai dengan Kompetensi Perekam Medis dan Informasi Kesehatan (PMIK)
Authors: Garmelia Elise , Lestari Sri , Golo Zefan Adiputra
Published: October 2022

Perekam Medis dan Informasi Kesehatan (PMIK) yang profesional wajib memberikan pelayanan yang berkualitas sesuai dengan standar kompetensi dan kode etik profesi. Tujuan penelitian ini meninjau pelaksanaan pekerjaan Penanggungjawab Rekam Medis (PJRM) di bangsal perawatan sesuai dengan Standar Kompetensi PMIK. Penelitian ini merupakan penelitian deskriptif kuantitatif dengan pendekatan crosssectional study. Penelitian dilakukan di 3( tiga) rumah sakit yang ada di kota Semarang dengan jumlah sampel 46 orang PJRM yang mengisi kuesioner secara online pada google form. Hasil penelitian menunjukkan terdapat 10 orang (21.7%) PJRM yang memiliki efektifitas kerja yang rendah. Area kompetensi Komunikasi Efektif berada pada kategori mampu (60.9%), Manajemen Data berada pada kategori mampu (50.0%), Klasifikasi Kodefikasi Penyakit dan Masalah Kesehatan berada pada kategori mampu (52.2%), Aplikasi Statistik, Epidemiologi dasar dan biomedik berada pada kategori mampu( 54.3%) dan Manajemen Pelayanan Rekam Medis berada pada kategori mampu (60.9). Hasil analisis bivariat menemukan bahwa setiap area kompetensi PMIK memiliki hubungan dengan efektivitas kerja (p<0.05). Hasil analisis multivariat menemukan bahwa setiap area kompetensi PMIK berpengaruh terhadap efektivitas kerja, dimana kompetensi Statistik, Epidemiologi dasar dan biomedik paling signifikan (p=0.02 < 0.05). Rumah sakit perlu melakukan evaluasi terhadap PJRM yang tidak efektif serta perlu melakukan rolling staf agar menjadi lebih aktif.
Analisis Pengodean Penyakit Berdasarkan ICD-10 Di Rumah Sakit TK. III Dr. Reksodiwiryo Padang
Authors: Putri Aprilia , Oktavia Dewi , Mayasari Nila
Published: October 2022

Rekam medis merupakan sumber informasi kesehatan pasien yang dikelola oleh praktisi informasi kesehatan. Informasi yang terdapat dalam rekam medis diolah untuk statistik asuhan kesehatan. Pengodean adalah pengklasifikasian data dan pemberian angka, huruf dan simbol (alfa numerik) untuk mewakili penyakit, prosedur dan bahan-bahan yang digunakan dalam pelaksanaan asuhan. Pengodean menguraikan penyakit, prosedur, layanan, operasi, cidera dan alasan kunjungan.Tujuan penelitian ini adalah untuk memberikan gambaran pengodean berdasarkan ICD-10 di Rumah Sakit TK. III dr. Reksodiwiryo Padang periode 15 Januari – 31 Januari 2018, dengan 288 pasien pulang dan jumlah tempat tidur 188 unit. Data tersebut kemudian diolah  dengan menggunakan komputer melalui Microsoft Excel. Berdasarkan ICD–10 penyakit terbanyak adalah Bronchopneumonia, unspecified dengan kode J18.0. Berdasarkan distribusi frekuensi Bab pada ICD-10, diagnosis terbanyak adalah Bab I dengan Sub Bab Certain Infection and paratic disease dengan jumlah persentase 19,10%. Pengelompokan prosedur berdasarkan diagnosis terbanyak adalah Appendectomy dengan kode 47.09. Diagnosis terbanyak menurut kode DTD adalah kode DTD 169 dengan diagnosis Pneumonia.  Kata kunci : Rekam Medis, Statistik, ICD-10
Tinjauan Penyebab Pengembalian Berkas Klaim Kasus Gawat Darurat
Authors: Agiwahyuanto Faik , Anjani Sylvia , Juwita Arinda
Published: October 2022

Pasien JKN di IGD dengan cara bayar menggunakan JKN KIS bisa diklaim kan dengan syarat bahwa diagnosis masuk merupakan dalam kriteria gawat darurat sesuai dengan syarat diagnosis yang sudah ditentukan oleh BPJS Kesehatan, pasien sudah terdaftar kepersertaanya, serta persyaratan berkas klaim lengkap. Jenis penelitian ini adalah deskriptif dengan pendekatan kasus (case-studies) yang datanya berupa data hasil observasi dan data hasil wawancara. Hasil penelitian berdasarkan observasi terhadap sampel 85 berkas pengembalian klaim pasien di IGD RSUD KRMT Wongsonegoro Kota Semarang ada 29 pasien (34,1%) memenuhi kriteria gawat darurat menurut BPJS Kesehatan dan tidak memenuhi kriteria gawat darurat 56 pasien (65,9%). Penyebab pengembalian berkas klaim kasus gawat darurat yaitu karena BPJS Kesehatan meminta konfirmasi kondisi emergency pasien 47 berkas (55,3%), alasan pasien pulang APS 22 berkas (25,8%), readmisi 7 berkas (8,23%), kurangnya kelengkapan surat kronologis 5 berkas (5,9%), kesalahan nilai GCS total 2 berkas (2,35%), dan alasan pasien dirujuk 2 berkas (2,35%).
Pengaruh Kesesuaian Tugas Teknologi Terhadap Kinerja Individu Dalam Menggunakan E-Medical Record System Di Instalasi Rawat Jalan RSU Dr. Wahidin Sudiro Husodo Kota Mojokerto
Authors: Mustikasari Ragil
Published: October 2022

Penelitian Pengaruh Kesesuaian Tugas Teknologi Terhadap Kinerja Individu Dalam Menggunakan E-Medical Record System di Instalasi Rawat Jalan RSU Dr. Wahidin Sudiro Husodo Kota Mojokerto merupakan penelitian yang berfokus pada kesesuaian tugas teknologi dan pemanfaatan teknologi informasi terhadap kinerja individu. Penelitian ini bertujuan untuk mengetahui pengaruh antara faktor kesesuaian teknologi terhadap tugas (Task Technology Fit) dengan kinerja (Performance) sehingga dapat memberikan masukan bagi rumah sakit dalam mengembangkan teknologi informasinya di kemudian hari. Jenis penelitian yang digunakan adalah kuantitatif analitik. Pengumpulan data melalui observasi dan penyebaran kuesioner kepada 26 responden, instrumen yang digunakan adalah IBM SPSS Statistic versi 22.0 serta uji hipotesis yang digunakan analisis regresi linier dan analisis jalur. Hasil pengujian hipotesis menunjukkan bahwa kesesuaian tugas teknologi berpengaruh terhadap kinerja individu karyawan di Instalasi Rawat Jalan RSU Dr. Wahidin Sudiro Husodo Kota Mojokerto serta pengujian jalur menunjukkan bahwa melalui jalur tidak langsung yakni melalui teknologi informasi yang sesuai dengan tugas-tugas individu yang ditingkatkan penggunaannya akan memberikan hasil kinerja individu karyawan yang lebih baik.
MiniSPD Stand for Testing Si-Detectors
Authors: Barlykov N. , Dudin V. , Enik T. , Ivanov A. , Kokoulina E. , Kutov A. , Martovitski E. , Nikitin V. , Popov V.
Published: October 2022

SPD (Spin Physics Detector) collaboration proposes to install a universal setup in the second interaction point of the NICA collider under construction (JINR, Dubna) to study the spin structure of the proton and deuteron. It plans to carry out research of spin-related phenomena with polarized proton and deuteron beams at a collision energy up to 27 GeV and a luminosity up to 1032 cm−2 s−1. MiniSPD stand is manufactured as a setup for testing SPD detector prototypes with cosmic muons at LHEP. It allows to carry out checkout of the Data Acquisition System (DAQ), the Detector Control System (DCS). Young physicists and students working at this test bench gain experience of work with real detectors of the future SPD setup. In this report, we give some information about the basic tasks of SPD projects. The results of simulation and comparison with data on cosmic rays at this stand for three modules of silicon plates are also presented.
Analysis of Charged Hadron Yield Distribution in Au+Au Collisions Using Different Parton Energy Loss Models
Authors: Babichev L. F. , Rusak Y. A.
Published: October 2022

In present paper it has been shown that yields of charged hadrons can give information on a type of the formed matter (cold or hot) in heavy-ion collisions and about validity of the parton energy loss models. For last purpose the HIJING Monte-Carlo generator is used modi.ed with parton energy loss models.
Optimising Renin-Angiotensin-Aldosterone System Inhibitor Therapy in Heart Failure and Resistant Hypertension: Challenges and Solutions
Authors: Bryson Kaedy
Published: October 2022

Renin-angiotensin-aldosterone system (RAAS) inhibitor therapy has been shown to be beneficial in patients with reduced left ventricular systolic function after an acute myocardial infarction, chronic systolic heart failure, and resistant hypertension. Although RAAS inhibitors are widely regarded as life-saving drugs, their use is often associated with changes in renal function, reducing elimination of potassium from the body. This can result in elevated concentrations of serum potassium, known as hyperkalaemia, which can in turn lead to potentially life-threatening conduction abnormalities and cardiac arrhythmias, and is associated with increased risk of death.

RAAS inhibitors are intrinsically linked to hyperkalaemia, with renin inhibitors, angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers, and mineral corticoid receptor antagonists all increasing serum potassium levels. The consequences of this side effect are treatment discontinuation or underdosing in patients with heart failure, which may contribute to a higher rate of heart failure-related hospitalisations and deaths. However, since the benefits of RAAS inhibitors outweigh the risks of hyperkalaemia, there remains the need to overcome these challenges rather than withdraw treatment.

Treatment options currently available for reducing potassium concentrations have many limitations, including uncertain efficacy, potential safety issues, as well as the fact that many therapies are temporising, only reducing serum potassium levels for a short amount of time, rather than eliminating excess potassium from the body. The clinical need to improve hyperkalaemia treatment options has led to the emergence of two novel agents: patiromer, which has been approved in the USA, and sodium zirconium cyclosilicate (SZC) which is currently in the clinical development stage. Studies have shown that these two new agents are efficacious in terms of achieving and maintaining normal potassium levels for up to 1 year and are well tolerated.
Ectopic Beats: How Many Count?
Authors: Simpson Rupert FG , Langtree Jessica , Mitchell Andrew RJ
Published: October 2022

Premature atrial and ventricular contractions, or ectopic beats, are frequently detected on routine electrocardiogram monitoring. They are often considered to be benign with no pathological significance; however, the literature suggests that higher ectopic burdens may have clinical importance. This paper reviews the current literature and provides the treating physician with an understanding of when ectopic beats should be deemed significant and when treatment may be appropriate.
Bioresorbable Coronary Scaffolds: Current State of Evidence
Authors: Goel Sunny , Raj Shiv , Sharma Abhishek , Gidwani Umesh , Frankel Robert , Shani Jacob
Published: October 2022

Second-generation drug-eluting stents are currently considered the standard of care in patients undergoing treatment for coronary artery disease with percutaneous coronary intervention. Despite significant improvements in stenting technology and stent material over the past three decades, the concern that a permanent metallic prosthesis within the coronary vasculature can serve as a trigger for stent-related adverse events, mainly stent thrombosis and in-stent restenosis, still persists. In order to overcome the disadvantages of drug-eluting stents there has been a robust development in the field of bioresorbable coronary scaffolds (BRS). These devices aim to provide temporary scaffolding to restore vessel patency and, after serving its purpose, fully degrade and thus allow restoration of vasomotion along with luminal enlargement. The initial experience with bioresorbable scaffolds in low-risk patients presenting with simple lesions was satisfying and generated optimism among interventional cardiologists by promising better patient outcomes. However, the unrestricted use of these devices in patients presenting with a higher baseline risk and more complex lesions came at the cost of alarmingly high rates of adverse cardiac events, especially the late device thrombosis. Although its non-inferiority compared to metallic everolimus-eluting stents was formally met in the clinical trials, there was a clear trend towards an increased occurrence of myocardial infarction and device thrombosis during the first year after device implantation, which persisted even at long-term follow-up raising concern on the future of BRS. This review article discusses the development, design, clinical data, and future directions in the field of BRS.
Interpreting Findings with Non-Vitamin K Antagonist Oral Anticoagulants in Atrial Fibrillation: Collective Views on Data from Seminal Studies to Present in Clinical Practice
Authors: Mughal Tabasum
Published: October 2022

Clinical trials show that non-vitamin K antagonist oral anticoagulants (NOACs) have good efficacy-safety profiles relative to warfarin across a broad spectrum of patients with non-valvular atrial fibrillation (NVAF). These findings are currently being confirmed for rivaroxaban through real-world evidence, with results from these studies consistent with results from Phase III randomised controlled trials (RCTs). Of all the NOACs, rivaroxaban currently has the most extensive real-world experience across different data sources (prospective and retrospective registries, database analyses, and prospective studies). Anticoagulant-related bleeding is still a concern amongst clinicians, however awareness of patient characteristics and other factors that can increase bleeding risk can assist in the proactive and effective management of bleeding episodes. Particularly, in atrial fibrillation (AF) patients with renal impairment who have an incrementally higher risk of bleeding and stroke, administration of NOACs versus vitamin K antagonists (VKAs) is beneficial. When dosed appropriately, NOACs such as rivaroxaban are effective in patients with renal impairment and offer an alternative to warfarin, with increased efficacy and decreased risk of critical bleeding events.
Pathophysiology of Ischaemic Mitral Valve Prolapse: A Review of the Evidence and Implications for Surgical Treatment
Authors: Nappi Francesco , Spadaccio Cristiano , Chello Massimo
Published: October 2022

Ischaemic mitral prolapse (IMP) is a pathologic entity encountered in about one-third of patients undergoing surgery for ischaemic mitral regurgitation. IMP is generally the result of a papillary muscle injury consequent to myocardial infarction, but the recent literature is progressively unveiling a more complex pathogenesis. The mechanisms underlying its development are the impairment of one or more components of the mitral apparatus, which comprises the annulus, chordae tendineae, papillary muscle, and left ventricular wall. IMP is not only a disorder of valvular function but also entails coexistent aspects of a geometric disturbance of the mitral valve configuration and of the left ventricular function and dimension. A correct understanding of all these aspects is crucial to guide and tailor the correct therapeutic strategy to be adopted. Localisation of prolapse and anatomic features of the prolapsed leaflets and the subvalvular apparatus should be carefully evaluated as also constituting the major determinants defining patient outcomes. This review will summarise our current understanding of the pathophysiology of and clinical evidence on IMP, with a particular focus on surgical treatment.
Arrhythmogenic Cardiomyopathy: Genetic Pathology, Inflammatory Syndrome, or both?
Authors: Rodríguez Héctor O.
Published: October 2022

Arrhythmogenic cardiomyopathy (ACM) affects mainly young athletes <35 years old and has a potential risk of malignant arrhythmias and sudden death. Different post-mortem and clinical studies have been conducted in North America, Asia, and Europe, with sharp differences in incidence and sex-associated pattern. Alterations in desmosome proteins, such as desmoglein, plakophilin, ion channels, or intracellular calcium handling proteins, have been highlighted as the principal cause of ACM, but the pathology has shown more complexity than initially described. This short review summarises the principal and more recent findings about ACM, mainly those related to inflammatory phenomena reported in the literature. Viral infections, especially enterovirus, have been associated with ACM and may be implicated in myocardial apoptosis, structural cardiac changes, and sudden death. Bartonella henselae and Sarcocystis infection have additionally been reported in ACM patients. Information regarding the role of proinflammatory cytokine or T cell infiltration and their possible role in sudden death is scarce, with increasing evidence of proinflammatory infiltrate associated with fibro-fatty ventricular patches related to biventricular affectation and worse outcomes. Nevertheless, findings taken from other sudden death-causing cardiomyopathies, such as viral myocarditis and Chagas disease, allow us to propose proinflammatory cytokines, such as tumour necrosis factor and interleukins 17 and 2, as possible serological markers of sudden death and/or ventricular dysfunction in order to conduct further research and identify diagnosis/prognosis markers for ACM.
The Relation of Religion and Culture in the Review of Indonesian Islamic Community Development
Authors: Nopryana Rahmah Dwi , Susilowati Indah
Published: October 2022

The article aims to find out the relationship between religion and culture according to religious and cultural texts that apply in the context of developing Indonesian Islamic society. The reserchers used descriptive qualitative research method and collect data from several related sources. The result show that the relationship between religion and culture has been going on for a long time in Indonesia, where this religion develops and is influenced by local culture and that culture is carried out by being escorted by religion to be in line with religious goals. Islam influences the development of Indonesian society by bringing their culture in line with the Shari'a so that they become shalah 'inda Allah and shalah 'inda nas. This is part of the peak of civilization for the Indonesian Muslim community. Religion recognizes and gives legality to culture that is in line with religious goals and does not oppose religious texts. However, what is still lacking is how the culture is created so that it is in harmony with religion

Keywords: Religion and Culture, Relation Religcion and Culture, Islamic Community Development
ERKEN ÇOCUKLUK DÖNEMİNİ PANDEMİ SÜRECİNDE YAŞAMIŞ İLKOKUL 1. SINIF ÖĞRENCİLERİNİN SOSYAL BECERİLERİNİN İNCELENMESİ
Authors: KOÇ Nuray
Published: October 2022

Bu araştırma, erken çocukluk dönemlerini pandemi sürecinde yaşamış 6-7 yaşlarındaki ilkokul 1. sınıf öğrencilerinin sosyal becerilerini aile ve öğretmen boyutlarıyla incelemeyi amaçlamaktadır. Araştırma yakınsayan paralel karma desen ile tasarlanmıştır. Çalışma grubunu tipik durum örnekleme yöntemi ile Bursa ilindeki bir özel ilkokulun 1. sınıfına devam eden 67 çocuk oluşturmuştur. Araştırmanın nicel verileri Ömeroğlu ve diğerleri (2012) tarafından geliştirilen “Okul Öncesi Sosyal Beceri Değerlendirme Ölçeği” ile çocukların velilerinden ve öğretmenlerinden toplanmıştır. Araştırmanın nitel verileri 4 ilkokul birinci sınıf öğretmeni ve 4 birinci sınıf velisi ile yarı yapılandırılmış görüşme formu aracılığıyla elde edilmiştir. Ayrıca araştırmacı 3 ay boyunca haftada bir gün öğrencilerle 30 dakika derse girerek gözlem yapmıştır. Araştırmanın nicel sonuçlarında tüm boyutlar arasında “duygularını yönetme becerileri” en düşük puanda kalmıştır. Aile görüşlerine göre “akademik destek becerilerinde” kızların lehine anlamlı fark çıkarken, öğretmen görüşlerine göre “arkadaşlık becerileri” boyutunda erkeklerin lehine anlamlı fark olduğu ortaya çıkmıştır. Aile ve öğretmenlerden toplanan veriler arasında yapılan korelasyon analizinde başlangıç becerileri (r: 0.312), akademik destek becerileri (r: 0.266) ve arkadaşlık becerileri (r: 0.276) boyutlarında aile ve öğretmen görüşleri arasında pozitif ilişki bulunmuştur. Araştırmanın nitel boyutunda ise pandeminin en çok “duygularını yönetme becerileri” üzerinde etkisi olduğu, bununla beraber akran zorbalığının ve dijital bağımlılığın çok sık görüldüğü belirlenmiştir.
Review of Fuel Cell Technologies and Evaluation of their Potential and Challenges for Electrified Propulsion Systems in Commercial Aviation
Authors:   German Aerospace Center (DLR), Kazula Stefan , de Graaf Stefanie ,   German Aerospace Center (DLR), Enghardt Lars ,   German Aerospace Center (DLR)
Published: October 2022

This paper presents an overview of the most relevant fuel cell types and identifies the most promising options for application in propulsion systems for commercial electrified aviation. The general design, operating principles and main characteristics of polymer electrolyte membrane, alkaline, direct methanol, phosphoric acid, molten carbonate and solid oxide fuel cells are described. Evaluation criteria are derived from aviation-specific requirements for the application of fuel cells in electrified aircraft. Based on these criteria, the presented fuel cell types are evaluated by means of a weighted point rating. The results of this evaluation reveal the high potential for application of solid oxide, low temperature and high temperature polymer electrolyte membrane fuel cells. Design challenges of all fuel cell types are being emphasised, for instance, concerning cold start, cooling and supply of pressurised air.
VIBRATION ANALYSES OF RADIAL TURBINE WHEELS CONSIDERING STRUCTURAL AND AERODYNAMIC MISTUNING
Authors:   Brandenburg University of Technology, Nakos Alex , Beirow Bernd ,   Brandenburg University of Technology, Zobel Arthur ,   University of Stuttgart, Stuttgart
Published: October 2022

Radial turbine wheels of exhaust gas turbochargers are permanently exposed to centrifugal, thermal, and aerodynamic loading. However, since these wheels are commonly designed as integral structures featuring relatively little mechanical damping, they are prone to the impact of unavoidable structural random mistuning, which may evoke severe magnifications of the forced response. Nonetheless, the safe operation of turbochargers has to be ensured at any time so that the contribution of aerodynamic damping is of particular importance. Moreover, the application of intentional mistuning is known to be a suitable measure to limit or even reduce the forced response by means of increasing the resulting aerodynamic damping. In this paper, two turbine wheels of the same type are considered, one manufactured with and another one without intentional mistuning. Experimental determinations of the mistuning patterns actually reveal deviations from the design intentions, which are considered in updated numerical models. Forced response simulations demonstrate that the targeted response reduction affected by intentional mistuning is achieved anyhow. Furthermore, the general robustness of the solution is proved with respect to the maximum forced response by means of comprehensive probabilistic numerical analyses addressing the impact of additional random structural mistuning, the magnitude of intentional mistuning, and aerodynamic mistuning.
Engineered stem cell exosomes for oral and maxillofacial wound healing
Authors: Hao Ming , Duan MengNa , Yang Zhijing , Zhou Hengzong , Li Shuangji , Xiang Jingcheng , Wu Han , Liu Huimin , Chang Lu , Wang Dongxu , Liu Weiwei
Published: October 2022

Wound healing of the oral and maxillofacial area affects the quality of life and mental health of the patient; therefore, effective therapies are required to promote wound healing. However, traditional treatment methods have limited efficacy. Exosomes secreted by stem cells used for oral and maxillofacial wound healing have shown outstanding results. Stem cell-derived exosomes possess the regenerative and repair ability of stem cells. Moreover, they are nontumorigenic and have good biosafety. However, the application of natural stem cell exosomes is limited owing to their low yield, impurity, lack of targeting, and low drug delivery rate. Many modification methods have been developed to engineered stem cell exosomes with beneficial properties, such as modifying parent cells and directly processing stem cell exosomes. These methods include coincubation, genetic engineering, electroporation, ultrasound, and artificial synthesis of engineered stem cell exosomes. These engineered stem cell exosomes can cargo nucleic acids, proteins, and small molecules. This gives them anti-inflammatory and cell proliferation regulatory abilities and enables the targeted promotion of efficient soft tissue repair after trauma. Engineered stem cell exosomes can decrease inflammation, promote fibroblast proliferation, and angiogenesis, and decrease scar formation to promote oral and maxillofacial wound healing, including diabetic and burn wounds. Thus, engineered stem cell exosomes are an effective treatment that has the potential for oral and maxillofacial wound healing.
Structural health assessment of pavement sections in the southern central United States using FWD parameters
Authors: Bastola Nitish R. , Souliman Mena I. , Dessouky Samer , Daoud Raja
Published: October 2022

Various Departments of Transportation in the South-Central States and elsewhere have made extensive use of the Non-Destructive Testing (NDT) surface deflection bowl data. The falling weight deflectometer (FWD) test is a popular NDT-based test used by transportation authorities to evaluate the performance of flexible pavement. Nevertheless, it is rare to develop a method for evaluating pavement sections using FWD data from all sensors. There is a constant demand for DOTs and highway agencies to have a streamlined approach that can be applied directly to their databases. This research focuses on extending and verifying the concept of previously published area ratio parameters to the pavement section of South-Central States (Arkansas, Louisiana, New Mexico, Oklahoma, and Texas) in order to properly analyze pavement performance. Simulation-based deflections are employed to strengthen deflection-based parameters and minimize the need for lengthy FWD field testing. Ninety-seven pavement sections in these states are being investigated for the implementation and validation of simplified processes that will be widely accessible to different transportation authorities in order to assess pavement problems at the network level.
Single-cell and single-nuclei RNA sequencing as powerful tools to decipher cellular heterogeneity and dysregulation in neurodegenerative diseases
Authors: Cuevas-Diaz Duran Raquel , González-Orozco Juan Carlos , Velasco Iván , Wu Jia Qian
Published: October 2022

Neurodegenerative diseases affect millions of people worldwide and there are currently no cures. Two types of common neurodegenerative diseases are Alzheimer’s (AD) and Parkinson’s disease (PD). Single-cell and single-nuclei RNA sequencing (scRNA-seq and snRNA-seq) have become powerful tools to elucidate the inherent complexity and dynamics of the central nervous system at cellular resolution. This technology has allowed the identification of cell types and states, providing new insights into cellular susceptibilities and molecular mechanisms underlying neurodegenerative conditions. Exciting research using high throughput scRNA-seq and snRNA-seq technologies to study AD and PD is emerging. Herein we review the recent progress in understanding these neurodegenerative diseases using these state-of-the-art technologies. We discuss the fundamental principles and implications of single-cell sequencing of the human brain. Moreover, we review some examples of the computational and analytical tools required to interpret the extensive amount of data generated from these assays. We conclude by highlighting challenges and limitations in the application of these technologies in the study of AD and PD.
Transcriptome and morphological analysis on the heart in gestational protein-restricted aging male rat offspring
Authors: Folguieri Marina S. , Franco Ana Teresa Barufi , Vieira André Schwambach , Gontijo José Antonio Rocha , Boer Patricia Aline
Published: October 2022

Background: Adverse factors that influence embryo/fetal development are correlated with increased risk of cardiovascular disease (CVD), type-2 diabetes, arterial hypertension, obesity, insulin resistance, impaired kidney development, psychiatric disorders, and enhanced susceptibility to oxidative stress and inflammatory processes in adulthood. Human and experimental studies have demonstrated a reciprocal relationship between birthweight and cardiovascular diseases, implying intrauterine adverse events in the onset of these abnormalities. In this way, it is plausible that confirmed functional and morphological heart changes caused by gestational protein restriction could be related to epigenetic effects anticipating cardiovascular disorders and reducing the survival time of these animals.

Methods: Wistar rats were divided into two groups according to the protein diet content offered during the pregnancy: a normal protein diet (NP, 17%) or a Low-protein diet (LP, 6%). The arterial pressure was measured, and the cardiac mass, cardiomyocytes area, gene expression, collagen content, and immunostaining of proteins were performed in the cardiac tissue of male 62-weeks old NP compared to LP offspring.

Results: In the current study, we showed a low birthweight followed by catch-up growth phenomena associated with high blood pressure development, increased heart collagen content, and cardiomyocyte area in 62-week-old LP offspring. mRNA sequencing analysis identified changes in the expression level of 137 genes, considering genes with a p-value < 0.05. No gene was. Significantly changed according to the adj-p-value. After gene-to-gene biological evaluation and relevance, the study demonstrated significant differences in genes linked to inflammatory activity, oxidative stress, apoptosis process, autophagy, hypertrophy, and fibrosis pathways resulting in heart function disorders.

Conclusion: The present study suggests that gestational protein restriction leads to early cardiac diseases in the LP progeny. It is hypothesized that heart dysfunction is associated with fibrosis, myocyte hypertrophy, and multiple abnormal gene expression. Considering the above findings, it may suppose a close link between maternal protein restriction, specific gene expression, and progressive heart failure.
Transcriptomic analysis of the human placenta reveals trophoblast dysfunction and augmented Wnt signalling associated with spontaneous preterm birth
Authors: Akram Khondoker M. , Kulkarni Neha S. , Brook Abbey , Wyles Matthew D. , Anumba Dilly O. C.
Published: October 2022

Preterm birth (PTB) is the leading cause of death in under-five children. Worldwide, annually, over 15 million babies are born preterm and 1 million of them die. The triggers and mechanisms of spontaneous PTB remain largely unknown. Most current therapies are ineffective and there is a paucity of reliable predictive biomarkers. Understanding the molecular mechanisms of spontaneous PTB is crucial for developing better diagnostics and therapeutics. To address this need, we conducted RNA-seq transcriptomic analysis, qRT-PCR and ELISA on fresh placental villous tissue from 20 spontaneous preterm and 20 spontaneous term deliveries, to identify genes and signalling pathways involved in the pathogenesis of PTB. Our differential gene expression, gene ontology and pathway analysis revealed several dysregulated genes (including OCLN, OPTN, KRT7, WNT7A, RSPO4, BAMBI, NFATC4, SLC6A13, SLC6A17, SLC26A8 and KLF8) associated with altered trophoblast functions. We identified dysregulated Wnt, oxytocin and cellular senescence signalling pathways in preterm placentas, where augmented Wnt signalling could play a pivotal role in the pathogenesis of PTB due to its diverse biological functions. We also reported two novel targets (ITPR2 and MYLK2) in the oxytocin signalling pathways for further study. Through bioinformatics analysis on DEGs, we identified four key miRNAs, - miR-524-5p, miR-520d-5p, miR-15a-5p and miR-424-5p - which were significantly downregulated in preterm placentas. These miRNAs may have regulatory roles in the aberrant gene expressions that we have observed in preterm placentas. We provide fresh molecular insight into the pathogenesis of spontaneous PTB which may drive further studies to develop new predictive biomarkers and therapeutics.
Novel insights related to the rise of KPC-producing Enterobacter cloacae complex strains within the nosocomial niche
Authors: Knecht Camila A. , García Allende Natalia , Álvarez Verónica E. , Prack McCormick Barbara , Massó Mariana G. , Piekar María , Campos Josefina , Fox Bárbara , Camicia Gabriela , Gambino Anahí S. , Leguina Ana Carolina del Valle , Donis Nicolás , Fernández-Canigia Liliana , Quiroga María Paula , Centrón Daniela
Published: October 2022

According to the World Health Organization, carbapenem-resistant Enterobacteriaceae (CRE) belong to the highest priority group for the development of new antibiotics. Argentina-WHONET data showed that Gram-negative resistance frequencies to imipenem have been increasing since 2010 mostly in two CRE bacteria: Klebsiella pneumoniae and Enterobacter cloacae Complex (ECC). This scenario is mirrored in our hospital. It is known that K. pneumoniae and the ECC coexist in the human body, but little is known about the outcome of these species producing KPC, and colonizing or infecting a patient. We aimed to contribute to the understanding of the rise of the ECC in Argentina, taking as a biological model both a patient colonized with two KPC-producing strains (one Enterobacter hormaechei and one K. pneumoniae) and in vitro competition assays with prevalent KPC-producing ECC (KPC-ECC) versus KPC-producing K. pneumoniae (KPC-Kp) high-risk clones from our institution. A KPC-producing E. hormaechei and later a KPC-Kp strain that colonized a patient shared an identical novel conjugative IncM1 plasmid harboring blaKPC-2. In addition, a total of 19 KPC-ECC and 58 KPC-Kp strains isolated from nosocomial infections revealed that high-risk clones KPC-ECC ST66 and ST78 as well as KPC-Kp ST11 and ST258 were prevalent and selected for competition assays. The competition assays with KCP-ECC ST45, ST66, and ST78 versus KPC-Kp ST11, ST18, and ST258 strains analyzed here showed no statistically significant difference. These assays evidenced that high-risk clones of KPC-ECC and KPC-Kp can coexist in the same hospital environment including the same patient, which explains from an ecological point of view that both species can exchange and share plasmids. These findings offer hints to explain the worldwide rise of KPC-ECC strains based on the ability of some pandemic clones to compete and occupy a certain niche. Taken together, the presence of the same new plasmid and the fitness results that showed that both strains can coexist within the same patient suggest that horizontal genetic transfer of blaKPC-2 within the patient cannot be ruled out. These findings highlight the constant interaction that these two species can keep in the hospital environment, which, in turn, can be related to the spread of KPC.