bluuebunny/crossref_metadata_2025 huggingface dataset:
CHANGES IN BRONCHIAL ASTHMA CONTROL AND INFLAMMATION BIOMARKERS DURING THE ALLERGEN-SPECIFIC IMMUNOTHERAPY AND ACCOMPANYINGTREATMENT
Authors: Eliseeva T I , Kul'gina Yu S , Balabolkin I I , Eliseeva T I , Kulgina U S , Balabolkin I I
Published: July 2021

Background. The work is devoted to the studying of the correspondence between the symptoms dynamics and the concentrations of the nitrogen oxide (NO) methabolites in the exhaled breath air condensate in patients with bronchial asthma (BA) during allergenospecific immunotherapy (ASIT) and accompanying treatment. Methods. The symptoms of BA were estimated using the Asthma Control Questionaire (ACQ). The inflammation biomarkers level (NO methabolites in the exhaled air condensate) was measured by the spectrofluorometric method of Griess.
Results. During ASIT and accompanying treatment (cetirizine or levocetirizine with basis BA therapy corresponding to the observed BA severity with allergens eliminated), the symptoms reduction (decrease in the total ACQ scores) was observed along with decrease of the total concentration of NO metabolites in blood. This was observed both for the steroid- naive patients and for the patients taking the inhaled corticosteroids (IC) treatment. Conclusion: In patients with mild BA, combination of ASIT and non-steroid accompanying therapy on the basis of cetirizine or levocetirizine results in the improvement of the BA control and reduction of the allergic inflammation in airways comaparable to the analogous processes in patients with moderate BA taking the analogous therapy but with IC included.
The cytokine status in infants with atopic dermatitis
Authors: Sentsova Tat'yana Borisovna , Denisova S N , Belitskaya M Yu , Sentsova T B , Denisova S N , Belitskaya M Yu
Published: July 2021

Background. To estimate the process of immunoregulation in infants aged 0-36 months with atopic dermatitis (AD) we have examined serum levels of cytokines and selectines in 89 infants with AD of different severity. Materials and methods. The serum concentration of total IgE was determined by the ELISA immunoenzyme method. For quantitative determination of the allergen-specific IgE and IgG to cow milk protein the non-concurrent immunoenzyme analysis was used. The serum levels of IFN-γ, IL-2, IL-4, IL-5, IL-12, IL-13 was determined by the ELISA - enzym-linked immunosorbent assay. Results of this study showed the role of cellular immunity in the development of allergic inflammation and humoral specific response with significant role of the local immune response, in ADinfants with predominantly IgE response/ In patients with mixed type of immune response (IgE+IgG) we revealed increased serum concentration of IL-4, IL-5, IL-12 and IL-13 compared with control group. We revealed high levels of leukocyte migration factors: ICAM-1 (p
MODERN PROBLEMS OF ALLERGEN VACCINES STANDARDIZATION
Authors: Zheltikova Tat'yana Mikhaylovna , Hrabina M , Antropova A B , Zheltikova T M , Hrabina M , Antropova A B
Published: July 2021

The article deals with the problems of standardization of allergen vaccines for ASIT performing. At present time there are no uniform requirements, criteria and methods which allow to standardize these preparations. There upon information about preparation or cultivation of raw materials, about methods used for allergen vaccines biological activity evaluation, and about units for this activity expression is very important for choosing the preparation for ASIT. The information about major clinically significant allergens concentration is necessary because ASIT both effectiveness and safety depend on it. Phostal and Staloral are examples of these thoroughly characterized and standardized allergen vaccines.
H1-ANTIHISTAMINES FOR THE TREATMENT OF CHILDREN WITH ALLERGIC DISEASE
Authors: Pampura A N , Pampura А N
Published: July 2021

The article is devoted to modern approaches of H1-antihistamines for the treatment of children with allergic
disease.
GUT BARRIER FUNCTION IN YOUNG CHILDREN WITH FOODALLERGY AND CAPABILITIES OF SPECIALIZED AMINO ACIDBASED FORMULAS USAGE
Authors: Makarova S G , Borovik T E , Yatsyk G V , Zvonkova N G , Makarova S , Borovik T , Yatsyk G , Zvonkova N
Published: July 2021

The article includes a brief literature review of clinical and experimental studies of intestinal uptake and absorption of macromolecules. Results of own research of the gut permeability for human milk α-lactalbumin in premature infants (30-36 weeks) are presented. The study revealed a reduction of gut permeability during the first months of life regardless of gestation age and type of feeding. Absorption of human milk α-lactalbumin did not decrease in babies with allergy symptoms, which appeared during the first month after birth. Study of gut barrier function in infants with skin and gastrointestinal manifestations of food allergy has shown maintenance and further increasing of intestinal permeability for human α-lactalbumin during the first year of life. In this regard, the indications for the use of specialized amino acids based formula Neocate were considered and the results of its application were presented.
The role of mutations in the genes FLG and GSTM1, and cytogenetic aberrations in the developmentof allergic occupational dermatitis in the oilfield workers of the north of Siberia
Authors: Il'inskikh Nikolay Nikolaevich , Shilov B V , Il'inskikh I N , Il'inskikh E N , Subbotin A M , Ilyinskikh N N , Shilov B V , Ilyinskikh I N , Ilyinskikh E N , Subbotin A M
Published: July 2021

Background. The objective of the investigation was to determine frequencies of micronucleated cells in the
buccal epithelium in relation to polymorphism of genes FLG and GSTM1 among oilfield workers suffered from
allergic occupational dermatitis.
Methods. There were 209 male oilfield workers examined with cases of allergic professional dermatitis at the age
of 21-39 years old. as a control group there were used 207 male workers without allergic occupational dermatitis.
we used genealogical method, micronucleous test and polymerase chain reaction to detect restriction fragments
of genes GSTM1 and FLG.
Results. it was detected that oilfield workers with genotypes contented homozygous mutated alleles GSTM1 (0/0)
gene showed the higher frequency of micronucleated epithelial cells. it was not detected for FLG gene allele
variants. among the examined oilfield workers with allergic occupational dermatitis there was nobody that would
have both mutated alleles of FLG (282de14/282de14) and homozygous GSTM1 (0/0) genes, while in the control
group we found some individuals of this type.
Conclusions. The significantly higher levels of cytogenetic aberrations in the oilfield workers suffered from allergic
occupational dermatitis are the result of combined effects of various factors on the genome. The investigation
can provide the basis for the elaboration of new scientific criteria for hiring staff in oilfields of west siberia.
OLYMP programme-basic clinical immunology programme as a part of continued medicaleducation for pediatritiansOLYMP SCHOOL IN NIZHNIY NOVGOROD REGION
Authors: Abelevich Mayya Mikhaylovna , Abelevich M M
Published: July 2021

In march 2011 OLIMP school (basics of clinical immunology for pediatricians) as a part of national project for
pediatrician's education of basics of clinical immunology was successfully organized in Nizhniy Novgorod with
help of Nutricia and Sandoz companies.
Program included an actual topics of immune caused diseases in general practice, immune aspects of atopic
diseases, nutritional influence to immunity of first - year - old children, evaluation of immune status of sickly
children, principals of immune therapy.
Cathelicidins - antimicrobal peptides and their role in immuno- pathology
Authors: Budikhina A S , Pinegin В V
Published: July 2021

Cathelicidins are a family of cationic amphipathic antimicrobial polypeptides, which play an important role in innate and adaptive immunity. The knowledge of biological effects of these peptides allows to use them not only as an alternative to common antimicrobial therapies. Cathelicidins may also be used for the re-activation of an immune system that has been suppressed by an infection or inflammation, for modulation of inflammation as lipopolysaccharide-binding drugs, and for the activation of regenerative processes. Besides, examination of cathelicidins may serve to detect individuals prone to infectious diseases, to monitor infectious process control in these patients, and to select efficient therapy.
Clinical and immunological phenotypes of the chronic rhinosinusitis with polyposis
Authors: Mokronosova M А , Ruyan Ju S , Mustafaeva D M , Smolnikova E V , Protasov P G
Published: July 2021

The pathogenesis of chronic rhinosinusitis with nasal polyposis is still unknown.
The aim. To estimate IgE-antibodies to staphylococcal enterotoxines and fungal allergens mix in nasal polyps'supernatant and sera
of three phenotypes of chronic rhinosinusitis.
Patients and methods. Chronic rhinosinusitis with nasal polyposis with aspirin intolerance - 12 patients, chronic rhinosinusitis
with nasal polyposis with atopy - 15 patients, chronic rhinosinusitis with nasal polyposis without atopy and aspirin intolerance -
10 patients, and 6 healthy persons were observed. The levels of ECP, tryptase, total IgE, IgE-antibodies to staphylococcal enterotoxines,
fungal mix in sera and supernatant of polyp's tissue were detected by ImmunoCaplOO (Phadia AB).
Results. The incidence of IgE-antibodies to staphylococcal enterotoxines makes up 12,6% in the sera of all patients, and 30% in polyp's
tissue in nonatopic patients and in none of atopics. The local production of IgE-antibodies to fungi in polyp's tissue was high and
revealed in 30-73% of all patients (more often in patients with aspirin intolerance - in 73% of cases). There was no dependence
between the incidence of IgE-antibodies to staphylococcal enterotoxines, fungal allergens mix in the sera and polyps and the chronic
rhinosinusitis with nasal polyposis.
Conclusion. The incidence of IgE-antibodies to staphylococcal enterotoxines, fungal allergens mix in polyp's tissue is higher than in
sera as in atopic as in nonatopic pts. There were IgE-antibodies to fungi in polyp's tissue in 73% of patients with aspirin intolerance. The
presence of IgE-antibodies did not influence on the level of ECP and severity of chronic rhinosinusitis with nasal polyposis .
Oral allergenspecific immunotherapy and the way of its improvement
Authors: Vykhrystsenkо L R
Published: July 2021

Oral method of allergen-specific immunotherapy (ASIT) is found to be the safe and available for the patients with allergic diseases. In this review the mechanisms of oral tolerance formation and the results of the efficacy and safety of oral ASIT are presented. The modern dosage forms of oral allergovaccines are analyzed.
Topical immunotherapy influence on citokins genes expression in skin and blood in atopicdermatitis patients
Authors: Filimonova T M , Elisyutina O G , Fedenko E S , Boldyreva M N , Smirnov V S
Published: July 2021

Background. To study the clinical effectiveness of topical immune modulator cream thymogen 0,05% and its influence on some immunological parameters in the skin and blood of atopic dermatitis (AD) patients. Materials and methods. 40 people were included in the study, who were divided into main (AD patients, n=20) and a control group (healthy donors, n=20). All AD patients received topical treatment with cream thymogen 0,05% during 14 days. Patients applied cream to affected skin 2 times daily. Clinical efficacy of the treatment was assessed by changes of following parameters: investigated global assessment (IGA), subjective evaluation of the itch intensity and skin dryness . Samples of skin biopsies and peripheral blood of AD patients and healthy donors were tested for gene expression of cytokines by polymerase chain reaction in real time. Results. Topical treatment with cream thymogen 0,05% during 14 days in all AD patients showed positive clinical effect: reduction of dryness and itch. Immunological analysis revealed a significant increasing of cytokine IL-7 gene expression and decreasing of cytokines IL-8, IL-5 genes expression (p
The peculiarities of cytokine status in children suffering from persistent allergic rhinitis during early stages of allergenspecific immunotherapy
Authors: Belan E B , Sadchikova T L , Antonov Uy V
Published: July 2021

Background. To study dynamics of cytokine status during early stages of allergen-specific immunotherapy (ASIT) in children suffering from persistent allergic rhinitis (PAR).
Methods. 30 children suffering from PAR have received complete course of ASIT. Serum levels ofILL-4, -5, -6, -8, -12, -13, sIL-2R were studied in 0, 7, 30 and 90 days and have been analyzed differentially in groups with good/excellent and incomplete effectiveness of treatment.
Results. Good/excellent effectiveness of completed course of ASIT has been demonstrated in 17/30 (56,7%) children, partial effectiveness has been demonstrated for 13/30 (43,3%) ones.The decreased IL-12 and IL-6 levels and the increase of sIL-2R production were described for good/excellent results of treatment, but insufficient effectiveness was characterized by delayed dynamics of these cytokines. IL-8 level was increased in both groups but decreased effectiveness was associated with early start and long duration of it. IL-4 production was decreased in the good/ excellent group while on the second one changes of cytokine level were absent. IL-13 and IL-5 synthesis were increased in both groups.
Conclusion. The effectiveness of ASIT in PAR patients depends on synthesis dynamics of ILL-4, -6, -8, -12, sIL-2R at the early treatment stages.
IgE-response to H. pylori in children with gastroduodenal diseases and allergy
Authors: Ilintseva N V , Mazurina S A , Gervazieva V B
Published: July 2021

Background. To evaluate the impact of atopic reactivity in humoral immune response to H. pylori in children with gastroduodenal diseases.
Materials and methods. In 69 children with gastroduodenal diseases and in 14 healthy people we revealed the total IgE level, IgM-, IgG-, IgA- and IgE-antibodies to H. pylori in serum samples, slgA in saliva and IgE- antibodies to H. pylori in supernatant samples of faeces with ELISA method.
Results. Chronic gastritis/gastroduodenitis in children with allergy are associated with a lower frequency of detection of IgG-and IgA- antibodies to H. pylori as well as with lower level of slgA and elevated levels of total IgE и IgE- antibodies to H. pylori in sera. Conversely, non-atopic patients showed high levels of slgA and high frequency of detection of IgA- antibodies to H. pylori. 60% of non-atopic children with gastroduodenal ulcers had elevated total IgE level, but IgE level to H. pylori was low as well as in healthy control group. IgE antibodies to H. pylori were detected in 95-100% of supernatant samples of faeces in all groups of patients with the highest level of IgE antibodies in children with gastroduodenal ulcers. It was revealed the direct correlation between the IgE antibodies to H. pylori level in serum and in supernatant samples of faeces in atopic children. Conclusion. The elevation of IgE antibodies to H. pylori is a result of constitutive Th2 immune response which reflects the mechanisms of mucosal immune defense independently from associated atopic diseases.
Allergy and vaccination
Authors: Medunitsyn N V
Published: July 2021

Data on post-vaccinal reactions and complications connected with antigens of vaccines, their admixtures and different kinds of additives presented. Causes of post-vaccinal reactions, the most frequent among them is allergy, have been analyzed.
Assessment of antimicrobial peptides(alpha-defensins) in atopic dermatitis and pyodermia patients blood
Authors: Tsyvkina E A , Fedenko E S , Budikhina A S , Pinegin B V
Published: July 2021

The purpose of research. The purpose was to investigate alpha-defensin levels in the circularly neutrophiles of atopic dermatitis and pyodermia patients in comparison with healthy donors.
Materials and methods. 27 patients with atopic dermatitis, 31 patients with pyodermia in comparison with 17 healthy donors were investigated. Intracellular alpha-defensin levels in neutrophils in the peripheral blood were estimated by flow cytometry with mouse anti-HNP-antibodies (Hy cult biotechnology).
Results. The alpha-defensins level in patients with atopic dermatitis and pyodermia was reduced in comparison with healthy donors. More expressed decrease of alpha-defensins level was obtained in patients with pyodermia and sever atopic dermatitis with skin infection.
Conclusion. Thus, a decrease of alpha-defensins levels in atopic dermatitis and pyodermia patients, possibly, is a marker of the chronic bacterial inflammation and may cause chronic bacterial skin disease, St. aureus colonizations and tolerance to the therapy.
IMMUNOTROPIC ACTIVITY OF SOUR MILK FERMENTEDCULTURES HYDROLISATE
Authors: Garanyan G S , Oganesyan E T , Khanferyan R A
Published: July 2021

The object of research is the hydrolysate of the lactobacteria components of the polycomponent sour milk stock
BKUglich №4 . The hydrolysate has been obtained by the fermentative hydrolysis with microbial rennin «eito»
The biological activity of obtained hydrolysate has been examined. Bacteria lysate immunotropic effects have been
found to be due to the increase of neutrophilic granulocyte phagocytic activity. It was supposed that the earlier
studied hydrolysate antioxidant activity caused by the normalization of the phagocyte superxide anionradical
production leads to the cell immunity normalization.
THE CLINICAL DISPLAYS AND THE FUNCTIONAL ACTIVITYOF RIBOSOMAL GENES IN ASTHMATIC CHILDREN
Authors: Ivanov V P , Stabrovskaya N V , Bogomazov A D , Trubnikova E V , Ivanov V P , Stabrovskaya N V , Bogomazov A D , Trubnikova E V
Published: July 2021

Background. To analyze the interrelations between the parameters of the functional activity of ribosomal genes and some clinical features in asthmatic children.
Material and methods. 78 asthmatic patients were included in the study. Standard methods of production and colouring of cytogenetic preparations were used. The functional activity of ribosomal genes was defined on five-point
system in arbitrary units. Statistical data processing was spent with the help of applied programs Statistica 6.0.
Results. The data about the level of the functional activity of ribosomal genes of asthmatic children (18,57 arbitrary
units) were obtained. In all patients the general functional activity of ribosomal genes parameters were correlated
with the number of leukocytes and the functional activity of ribosomal genes localized in GHchromosomes parameter -with the level of immunoglobulin E. We constructed the discrimination model according to the disease severity
index which included 4 significant parameters: bands number, disease manifestation age, blood sedimentation rate
and active ribosomal genes copies number.
Conclusion. Our data give evidence about the interrelations between the functional activity of ribosomal genes parameters and some clinical features in asthmatic children. The number of active ribosomal genes copies is considered
to be one of the significant features of disease activity.
Pimecrolimus 1 % cream in treatment of steroid rosacea in AD patients
Authors: Elisyutina O G , Fedenko E S
Published: July 2021

The own data concerning cream pimecrolimus 1% application in atopic dermatitis patients complicated with steroid rosacea are presented.
New approaches in diagnostics of food allergy and effectiveness of dietotherapy in infants
Authors: Borovick T Ae , Makarova S G , Semenova N N , Darchia S N , Shumilina L V , Shikchov S N , Chekannikova A P
Published: July 2021

In the article the modern approaches to diagnostics of food allergy with the focus on other thenlgE-related forms of gastrointestinal hypersensitivity in infants are described. The results of the own study on efficacy assessment of new diagnostic system - immune-enzyme assay «Lactest» for specific IgE and IgG levels against food allergens as well as proteins from baby food estimation in sera of infants are presented. Dietotherapy for infants with food allergy based on immune-enzyme assay «Lactest» is described.
Nutritional Management of food allergy infants
Authors: Pampura A N , Pampura A N
Published: July 2021

In lecture expound principles of individual approach to diet therapy of infants with various forms of a food allergy.
Algorithms of choice diet therapy at children with a food allergy at various variants feedings are suggest.
Pharmacotherapy of chronic idiopatic urticaria in children
Authors: Pampura A N
Published: July 2021

Treatment based on published and own data on chronic idiopathic urticaria in children is presented. The necessity of individual approach to Нх-antihistamines and alternative drug therapy is shown.
Participation of Neuropeptides and β-endorphin in Pathogenesis of Atopic Dermatitis. Evaluation of Levocetirizine Effectiveness upon Neuropeptides' Levels at Children with Atopic Dermatitis
Authors: Revyakina V A , Agaphonov A S , Sentsova T B , Phabrika M P
Published: July 2021

Objective. Determination of the role of neuropeptides and p-endorphin in developmental mechanisms of
atopic dermatitis, and assessment of the effectiveness of levocetirizine, a modern Hl-antihistamine, on atopic
dermatitis symptoms and its influence on the SCORAD index in children with atopic dermatitis.
Materials and methods. 84 children with atopic dermatitis of moderate-to-severe or severe clinical nature,
aged 1 to 17 years, were enrolled in this (double-blind or open, randomised, etc.) study. Patients were treated
with levocetirizine 5 mg once daily during 14 days. The levels of P substance, neurokinin A, neurokinin B,
and p-endorphin in blood serum, as well as levocetirizine effectiveness on disease symptoms and the SCORAD
index were evaluated.
Results. Lower neuropeptide levels were associated with disease severity; children with severe atopic
dermatitis had lower neuropeptide values. Before treatment, SCORAD index in children with severe atopic
dermatitis was 76,5±11,3, and after 7 days of therapy SCORAD index was 14±6,2 points (p< 0,01). By the 7th
day after treatment initiation, the acute atopic dermatitis became of subacute nature and was accompanied
by a regression of the cutaneous eruption in the form of significant decreasing of skin manifestations and
pruritus, absence of new eruption and normalized sleep.
In children with moderate-to-severe atopic dermatitis the SCORAD index before levocetirizine treatment
was 44,2±3,4 points; on the 3rd day, this index was 20,4±2,6 points; and on the 7th day there was a complete
absence of clinical symptoms of the main disease.
Levocetirizine administration led to the disappearance of the disease clinical symptoms and pruritus in
children with moderate-to-severe atopic dermatitis.
Conclusion. This trial demonstrated that neuropeptides are involved in the developmental mechanisms of
atopic dermatitis and that levocetirizine can significantly improve the signs and symptoms of children with
moderate-to-severe or severe atopic dermatitis.
Microdisperse cellulose powder for prevention of allergic rhinitis in children
Authors: Geppe N A , Snegotskaya M N , Kolosova N G , Konopelko O U , Mashukova N G , Ozerskaya I M , Farber I M
Published: July 2021

The data of open comparative clinical study is given according to efficiency and safety of microdisperse cellulose powder used for prevention and treatment of allergic rhinitis in children.
CLINICAL EFFICIENCY AND ANTI-INFLAMMATORY ACTIVITYOF THERAPY IN CHILDREN WITH PERENNIAL ALLERGICRHINITIS
Authors: Petrov V I , Maljuzhinskaya N V , Shishimorov I N , Razvalyaeva A V
Published: July 2021

Background. Intranasal corticosteroids and nonsedating antihistamines are the drug classes most often prescribed
to treat allergic rhinitis (AR). Treatment guidelines recommend a combination of these agents for moderate to severe AR. Objective: To compare the efficacy of mometasone furoate (MF) nasal spray plus desloratadine (DL)
with that of monotherapy with the individual agents in 6-16 years old patients with perennial AR.
Methods. A prospective, randomized, open label, parallel group study of the efficiency of MF nasal spray plus DL and of monotherapy with MF or DL in children with persistent allergic rhinitis aged 6-16 in a 12week period
was conducted. The efficacy of therapy was evaluated by level of markers of an allergic inflammation, indicators
of a bronchial hyperresponsiveness and by dynamics of clinical symptoms.
Results. Combined therapy (DL+MF) restores balance of cytokines: increase the Тh1 activity and decrease the Т2 activity. Combined therapy found to be effective in the majority of AR patients.
Сnclusion. Combined therapy with MF and DL in the treatment of perennial AR in children has clinical advan60
Specific subcutaneus immunotherapy by a birch extract absorbed onto calcium phosphate
Authors: Mokronosova M A , Korovkina E S
Published: July 2021

Background. Allergic rhinitis is a common disease, affecting 25-35% of the population. Birch pollen is a significant cause of immediate
hypersensitivity among sensitive subjects, affecting about 80% of the population in the central part of Russian Federation. Specific
subcutaneus immunotherapy (SCIT) is the only treatment producing lasting clinical improvement in patients with allergy.
The aim, of the study was to investigate the efficacy of one - year SCIT for allergic rhinoconjunctivitis for birch pollen using the
Average Rhinoconjunctivitis Total Symptom Score (ARTSS) and Average Rescue Medication Score (ARMS).
Materials and methods. 54 subjects with IgE-mediated seasonal allergic rhinoconjunctivitis with/without seasonal asthma were
enrolled; 47 patients with pollen allergy were included in a control group. All patients were sensitized to birch pollen-allergens.
SCIT was performed during 9 months 2009-2010 years by a birch extract standardized in IR and absorbed onto calcium phosphate
(Phostal, France). Patients were asked to complete diary during the birch pollination season (from 1 April to 1 June). Pollen grains
were counted daily during the pollen seasons by standardized protocol and the amount of pollen was expressed as the number of
pollen grains/m3 air. The ARTSS was derived from individual symptom scores for nasal and eye symptoms during the pollen season.
In addition there was a daily score for the use of rescue medication (ARMS). Rescue medication allowed included Hl-antihistamines,
nasal steroids, oral steroids; each puff, drop (nostril/eye), tablet counted as one point.
Results. The seasonal pollen counts and the duration of the pollen season had differed in 2009 and in 2010. Reduction in ARTSS of
29% and decrease in ARMS of 28,9% were found in the birch pollen season for subjects treated with the SCIT compared with controls
after one year of treatment. The immunotherapy after the end of the treatment was not effective in 3 patients (5%).
Conclusion. Immunotherapy by Phostal shows clinical effect on development of seasonal rhinoconjunctivitis. The decrease in ARTSS
for Phostal-treated patients that occurred in parallel with a marked reduction in their requirement for ARMS provides additional
evidence for the efficacy of SCIT over and above usual pharmacotherapy for rhinitis.
Relationship between allergic rhinitis and bronchialasthma
Authors: Emelianov A V , Elizarova T E , Sergeeva G R
Published: July 2021

The aim of the review is to discuss different aspects and mechanisms of the relationship between allergic rhinitis and asthma. Therapeutic strategy has to include the treatment of both diseases. Modern treatment of allergic rhinitis may improve control of concomitant asthma.
THE EFFICACY AND SAFETY OF FOSTER IN PATIENTS WITH BRONCHIAL ASTHMA IN ROUTINE CLINICAL PRACTICEon behalf of the Research Group «ESTAFETA» to assess the efficacy and safety of the drug «Foster» in patients with asthma in routine clinical practice
Authors: Iljina N I , Pavlova K S
Published: July 2021

Background. Evaluation of the efficacy and safety of the drug Foster (fixed combination of beclomethasone di-propionate 100 mcg and formoterol 6 micrograms per single dose) in metered-dose aerosol inhaler technology Modulite® in patients with bronchial asthma (BA).
Methods. Prospective non comparative multicenter open observational study. Study group consisted of 120 practicing physicians from the 92 hospitals in 21 cities of Russia. Analyzed 557 case report forms of patients with moderate persistent asthma treated with Foster during 12 weeks who needed to correct the basic therapy (according to asthma control criteria GINA 2006).
Results. The effectiveness of treatment with Foster was observed in 555 (99,6%) of 557 patients, who showed improvement in lung function, decreased severity of symptoms, reducing the need for symptomatic therapy compared with baseline and improved asthma control in general.
Conclusions. In most cases, control over moderate and severe persistent asthma can be improved by the combined therapy of inhaled steroids (ICS) and в2-agonist long-acting (LABA). In this case, Foster is a drug of choice with a fixed combination of ICS and LABA. Extra-fine form of the drug (thanks to innovative technology Modulite®) is evenly distributed in central and peripheral airways, providing good therapeutic effect of using of low doses of ICS and reducing the likelihood of side effects.
Features of allergic symptoms during the winter period
Authors: Luss L V
Published: July 2021

Seasonal features and clinical course of allergic diseases in wintertime are presented with the accent to their treatment.
Activated zinc pyrithione. Mechanism of action. Clinical application
Authors: Skripkin Yu K , Petrovskiy F I , Fedenko E S , Pampura A N , Korostovtsev D S , Fassa khov P C , Sukmanskaya E O , Skripkin Yu K , Petrovskiy F I , Fedenko E S , Pampura A N , Korostovtsev D S , Fassahov R S , Sukmanskaja E O
Published: July 2021

Activated zinc pyrithione (ZP) has a number of contributory pharmacodynamic effects that provide it's efficacy in psoriasis and atopic dermatitis. Because of ZP impairs the integrity of cell membranes it is active against many bacterial and yeast species. In psoriasis and atopic dermatitis ZP therapy is accompanied by accelerated cells' apoptosis of lower layers of epidermis and atopic inflammatory infiltrate as well as by decrease in skin neutrophils and lymphocytes. The broad spectrum of pharmacological activities together with wide clinical experience worldwide endorse activated ZP as effective and safe nonsteroidal medication for topical therapy of different dermatoses and support it's use in dermatology, paediatrics and allergy.
RELATIONSHIP BETWEEN BUDGETARY PLANNING AND FINANCIAL PERFORMANCE OF COUNTY GOVERNMENT OF KERICHO, KENYA
Authors: Margret Chepkorir  , Dr. Willy Rugutt  , Dr. Penina Langat
Published: July 2021

Budgeting has become a fundamental issue for many organizations and business entities across the globe. Despite the availability of legal framework on budgetary planning in the public sector, County Governments are still facing challenges such as delays in payment to suppliers, budget deficit, stalled projects and poor development records. It is on this basis that this study sought to investigate the relationship between budgetary planning and financial performance of County Government of Kericho, Kenya. The study was guided by allocation of resources theory, institutional theory and expenditure theory. The study adopted a correlation survey research design. The target population for the study was 3,848 employees from 12 departments of the County Government of Kericho. Proportion method and simple random sampling technique were used to ascertain sample size for the study. Both secondary and primary data were used for data collection where secondary data was collected from records in the County Government offices and primary data collected through structured questionnaires. Validity was ensured by discussing the content of the questionnaire with the supervisors and subject experts before going to the field. Cronbach’s alpha coefficient was used to determine the reliability of the research instrument which was found to be 0.873 which was considered ideal. Data was analyzed using descriptive and inferential statistics. Descriptive statistics was presented by frequency tables, charts and graphs while inferential statistics were presented by correlation and regression models. The findings established that there was significant statistical relationship between budgetary planning (β =1.096, P<0.05). The study concluded that the independent variables understudy contributed 60.5 variation on financial performance (R2 =0.605). The study recommends that for efficient budgetary planning the county government should set realistic revenue targets so as to ensure that expected expenditure matches expected incomes and also acquire and train staff involved in budget planning for efficient planning process.
KEY WORDS: Budgetary Process, Budgetary Planning, Financial Performance, County Governments in Kenya
EFFECTIVENESS OF HAND SPLINTING AND SENSORY RE-EDUCATION TO REGAIN FUNCTIONALITY AFTER WRIST DROP
Authors: Dr. Megha Satyawali  , Dr. S.K. Meena  , Dr. Neha Jain
Published: July 2021

Hand problems, which could be cosmetic or functional or both, are hard to hide. Hands function affectedly concern to gesture and express, touch and care, dress, and feed. Impairments can be annihilating. The incidence of upper extremity injuries is significant and accounts for about one-third of all injuries. This study is conducted in order to find the effectiveness of splinting and sensory reeducation in the patient with wrist drop. A different subject prospective, experimental, flexible pre-and-posttest intervention design followed by descriptive analysis with questionnaire has been used for the purpose of this study. Baseline screening assessment was done by using DASH, Goniometer, oxford grading for muscle strength and monofilaments. Out-trigger hand splint was provided to all the subject. Sensory re-education training was given to the patients with conventional therapy for better result, 5 days/week over a period of 12 weeks. After 12 weeks of therapy, post-test will be done by using DASH, Goniometer, oxford grading for muscle strength and monofilament to obtain results. The unpaired t test (for quantitative data to compare two independent two groups was used for quantitative data comparison of all clinical indicators. Chi-square test and fisher exact test were used for qualitative data whenever two or more than two groups were used to compare. Level of significance was set at P≤0.05.The individual overall growth has been considered in the therapy sessions as the patient’s personal life, self-confidence, locomotion and day to day activities were hampered but after therapy session the individuals each aspect has overall growth including muscle strength which helps the patient to lift weight up to 2kg and make them able to hold the objects of different size and shapes for e.g. mainly patient has developed cylindrical, conical and spherical grasp.
KEY WORDS : Sensory re-education, Wrist drop, DASH, Splinting, Functionality
Calidad de atención del control prenatal en un establecimiento de salud del distrito de Lambayeque, Perú, 2019 a 2020
Authors: Cueva-Pérez Isai Caleb , Guivin-Ballena Bertha Elianets , Soto-Cáceres Víctor Alberto
Published: July 2021

Objetivo: el objetivo de este estudio es evaluar la calidad de atención del control prenatal de las gestantes atendidas en el centro de salud San Martín de Lambayeque, Perú, 2019 a 2020. Material y métodos: el estudio corresponde a una investigación no experimental cuantitativa, de tipo descriptiva. El instrumento para recolección de datos fue la encuesta Servqual modificada, aplicada a una muestra total de 144 gestantes atendidas en los consultorios de atención prenatal. Resultados: Las gestantes mostraron satisfacción por la atención recibida en su mayoría (62 %), mientras que un regular porcentaje mostraron insatisfacción con la atención prenatal (38 %). Según las diferentes dimensiones de Servqual, las gestantes mostraron satisfacción en fiabilidad (65,6 %), capacidad de respuesta (68,9 %), seguridad (70 %), empatía (80 %) y aspectos tangibles (77 %). Conclusión: En términos generales según el promedio general de satisfacción en las dimensiones Servqual se determinó como buena la calidad de atención prenatal.
FORMULASI SEDIAAN LOTION MENGGUNAKAN KOLAGEN TULANG IKAN PATIN (PANGASIUS SP) SEBAGAI PELEMBAB KULIT
Authors: Hepni Hepni
Published: July 2021

Background: In general, people consume catfish meat as a source of protein and a high content of omega 3, while the bones are disposed of as waste. Collagen is a protein derivative that has the effect of maintaining skin elasticity. Objective: To find out whether the catfish bone collagen can be formulated into lotions which in certain consentration can moisturize and do not irritate the skin. Method: Extraction of collagen from catfish bones, characterization of collagen by infrared spectrophotometry, making collagen lotion of catfish bones with a concentration of 1%, 1.5%, 2.5%, 3.5% and evaluation of collagen lotion preparations and test the ability of the preparation to moisturize. skin using a Skin moisturizer detector (SG- ed statistically using the ANOVA test with SPSS 20 Free trial. Result: Catfish bones contained collagen in waves of 3250-3350 cm-1 and 1260-1630 cm-1 which indicated the presence of amine and amide groups. The statistical test results show the probability is smaller than 0.05. The highest humidity was in the FE formula which contained 3.5% collagen with a moisture percentage of 53.0% with a level of "Moist" but lower than the lotions on the market with a percentage of 54.3%. Conclusion: Catfish bone collagen can be formulated into oil-in-water (M/A) emulsion type lotion.

 

Abstrak

Pendahuluan: Secara umum masyarakat mengkonsumsi daging ikan patin sebagai sumber protein dan kandungan omega 3 yang tinggi, sedangkan tulangnya dibuang sebagai limbah. Kolagen merupakan salah satu turunan protein yang mempunyai efek untuk mempertahankan kekenyalan kulit. Tujuan: Untuk mengetahui apakah kolagen tulang ikan patin dapat diformulasikan kedalam sediaan lotion yang dalam konsentrasi tertentu dapat melembabkan dan tidak mengiritasi kulit. Metode: Ekstraksi kolagen dari tulang ikan patin, karakterisasi kolagen dengan spektrofotometri inframerah, pembuatan lotion kolagen tulang ikan patin dengan konsentrasi 1%, 1,5%, 2,5%, 3,5% dan evaluasi sediaan lotion kolagen serta uji kemampuan sediaan melembabkan kulit memakai alat Skin moisturizer detector (SG-7D ) serta hasilnya diuji secara statistik memakai uji ANOVA dengan SPSS 20 Free trial. Hasil: Tulang ikan patin mengandung kolagen pada gelombang 32503350 cm-1 dan 1260-1630 cm-1 yang menunjukkan adanya gugus amina dan amida. Hasil uji statistik menunjukkan probabilitas lebih kecil dari 0,05. Kelembaban tertinggi yaitu pada formula FE yang mengandung 3,5% kolagen dengan persentase kelembaban 53,0% dengan level ”Lembab” tetapi lebih rendah dari lotion yang beredar dipasaran dengan persentase sebesar 54,3%. Kesimpulan: Kolagen tulang ikan patin dapat diformulasi menjadi sediaan lotion tipe emulsi minyak dalam air (M/A).
PERSEPSI MASYARAKAT BATAK TOBA TENTANG PENDIDIKAN SEKS BAGI REMAJA DI LINGKUNGAN PARPAREAN III KELURAHAN PARPAREAN III KECAMATAN PORSEA KABUPATEN TOBA TAHUN 2020
Authors: Munarni Munarni
Published: July 2021

Sex education is a clear and correct information regarding the issue of human sexuality, which includes the occurrence of conception, pregnancy, sexual behavior, sexual relations and health, psychological and social aspects. The issue of sexual education provided should be related to the norms prevailing in society, what is prohibited, what is legal and how to do it without violating the rules that apply in society. This study aims to determine the perception of the Batak Toba community about sex education for adolescents in the Parparean III environment, Parparean III Village. This research is descriptive using primary data obtained through a questionnaire. The sample in this study was the Batak Toba people who had teenagers who were obtained using a total sampling technique. From the results of this study obtained data, respondents who have positive perceptions as many as 43 people (81.1%) and negative 10 people (18.9%). Given the importance of sex education for adolescents, it is necessary to coordinate between the government, health workers and the community to unifying perceptions about sex education so that adolescents get clear and correct information about sexuality to improve their reproductive health.

 

Abstrak

Pendidikan seks adalah suatu informasi mengenai persoalan seksualitas manusia yang jelas dan benar, yang meliputi terjadinya pembuahan, kehamilan, tingkah laku seksual, hubungan seksual dan aspek-aspek kesehatan, kejiwaaan dan kemasyarakatan. Masalah pendidikan seksual yang diberikan sepatutnya berkaitan dengan norma-norma yang berlaku di masyarakat, apa yang dilarang, apa yang dilazimkan dan bagaimana melakukannya tanpa melanggar aturan-aturan yang berlaku di masyarakat. Penelitian ini bertujan untuk mengetahui persepsi masyarakat Batak Toba tentang pendidikan seks bagi remaja di Lingkungan Parparean III Kelurahan Parparean III. Penelitian ini bersifat deskriptif dengan menggunakan data primer yang didapat melalui kuesioner. Sampel dalam penelitian ini adalah masyarakat Batak Toba yang memiliki remaja yang didapat menggunakan teknik total sampling. Dari hasil penelitian ini didapat data, responden yang memiliki persepsi positif sebanyak 43 orang (81,1%) dan negatif 10 orang (18,9%).Mengingat pentingnya pendidikan seks bagi remaja, perlu adanya koordinasi antara pemerintah, tenaga kesehatan dan masyarakat untuk menyatukan persepsi mengenai pendidikan seks agar remaja mendapatkan informasi yang jelas dan benar mengenai seksualitas untuk meningkatan kesehatan reproduksinya.
PENGARUH AKTIFITAS FISIK DAN CEMAS TERHADAP AKTIVITAS SEKSUAL PADA IBU MENOPAUSE DI KECAMATAN MUARA DUA KOTA LHOKSEUMAWE
Authors: Nurmila Nurmila , Jasmiati Jasmiati , Elizar Elizar
Published: July 2021

The decline as the effect of menopause will cause the decline in various body system, including the decline in mothers’ sexuality. It can happen when there are physical change, psychological change, the lack of information and knowledge of the change in mothers, and people’s negative perception on sexuality in old age. The objective of the research was to analyze factors physical activit, and apprehensiveness, which influenced sexual activity of menopause mothers in Muara Dua Subdistrict, Lhokseumawe. The research used observational method with cross sectional design. The population was all menopause mothers who still had spouses and lived in Muara Dua Subdistrict, and 82 of them were used as the samples. The data were analyzed by using univatriate analysis, bivatriate analysis. The result of the research showed that of 82 respondents, 56.1% of them were not sexually active. The result of chi square statistic test showed that the variables of physical activities and apprehensiveness (p < 0.001). It is recommended that menopause mothers should keep the health and bodies fresh, decrease physical activities by cooperating with families, especially husbands and should be willing to tell about sexuality in the menopause period to decrease apprehensiveness. Mothers and their husbands should have good perception on sexual activity during menopause so that they can increase their sexual life during menopause.

 

Abstrak

Kemunduran akibat masa menopause akan membawa dampak pada penurunan berbagai sistim tubuh termasuk penurunan seksualitas ibu. Penurunan seksualitas pada ibu menopause dapat terjadi karena adanya perubahan pada fisik. Jenis penelitian adalah observasional dengan pendekatan Cross-sectional. Penelitian ini bertujuan menganalisis hubungan aktivitas fisik dan cemas terhadap aktivitas seksual pada ibu menopause. Populasi pada penelitian ini adalah semua ibu menopause yang ada di kecamatan Muara Dua sebanyak 544 orang. Sampel dalam penelitian ini diambil berdasarkan rumus Lameshow dengan jumlah sampel 82 orang. Analisis data menggunakan analisis univariat, analisis bivariat dengan uji Chi-squre. Hasil penelitian dengan uji Chi-square menunjukkan hasil bahwa aktivitas fisik dan cemas sangat berpengaruh terhadap aktivitas seksual yaitu (p < 0,001). Disarankan kepada tenaga kesehatan terutama bidan dan perawat yang bertugas di Puskesmas terutama saat kegiatan di luar gedung agar dapat melakukan komunikasi, memberikan informasi dan edukasi terutama tentang aktivitas seksualitas masa menopause.
HUBUNGAN MEDIA KOMUNIKASI DENGAN AKTIVITAS SEKSUAL BERISIKO PADA REMAJA LAKI-LAKI DI MADRASAH ALIYAH NEGERI KOTA LHOKSEUMAWE
Authors: Rosyita Rosyita , Prihatin Nova Sumaini , Putri Hendrika Wijaya Kartini
Published: July 2021

Based on WHO (World Health Organization) data showing nearly 43 million more (18.3%) of the total population is teenagers. The famous issues among teenagers one of them related to sexual behavior. The purpose of this study to analyze the relationship of communication media  with risky sexual activity in adolescent boys in MAN of  Kota Lhokseumawe in 2018. This research uses mixed methods with cross sectional design on quantitative research and sequential explanatory strategy in qualitative research. The population in this research are students of class X and XI a number of 120 students. The sample that used for quantitative research is total population while for qualitative research is 18 people with inclusion and exclusion criteria. Collecting data on quantitative research is by distributing questionnaires while in qualitative research with in-dept interview and Focus Group Discussion (FGD). Analysis of bivariate data using chi square test. Qualitative data analysis is done by Thematical Analysis.The result of bivariate analysis about communication media obtained result p value = 0,000, RP = 2,519. The result of indept-interview is found that besides communication media factor to risky sexual activity such as peer factor, parents, faith and drug users. It is expected that policy makers should increase supervision over existing school rules.

 

Abstrak

Berdasarkan data WHO (Word Health Organization) menunjukkan hampir 43 juta jiwa lebih (18,3%) dari keseluruhan total jumlah penduduk adalah remaja. Masalah yang menonjol dikalangan remaja salah satunya terkait dengan perilaku seksual. Tujuan penelitian ini menganalisis hubungan media komunikasi dengan aktivitas seksual berisiko pada remaja laki-laki di MAN Kota Lhokseumawe tahun 2018. Penelitian ini menggunakan mixed methods dengan desain cross sectional pada penelitian kuantitatif dan strategi sequential explanatory pada penelitian kualitatif. Sampel yang digunakan untuk penelitian kuantitatif sejumlah 120 orang dan untuk penelitian kualitatif berjumlah 18 orang. Pengumpulan data pada penelitian kuantitatif dengan cara penyebaran kuesioner sedangkan pada penelitian kualitatif dengan cara indept interview dan Focus Group Discussion (FGD). Analisis data bivariat menggunakan uji chi square. Analisis  data kualitatif dilakukan degan cara Thematical Analysis. Hasil analisis bivariat tentang media komunikasi diperoleh hasil p value =0,000, RP=2,519, hasil tersebut menunjukkan bahwa adanya hubungan media komunikasi dengan aktivitas seksual berisiko. Hasil indept-interview didapatkan bahwa selain faktor media komunikasi terdapat faktor lain yang berhubungan dengan aktivitas seksual berisiko yaitu faktor teman sebaya, orang tua, keimanan dan pengguna NAPZA. Diharapkan kepada pengambil kebijakan untuk lebih meningkatkan pengawasan terhadap peraturan yang sudah berlaku disekolah.