bluuebunny/crossref_metadata_2025 huggingface dataset:
FAMILY PLANNING VILLAGE PROGRAM IN RESPONSE TO THE USE OF LONG-TERM CONTRACEPTIVE METHOD
Authors: Huda Naddratul , Baroya Ni mal , Sandra Christyana , Hariastuti Iswari
Published: May 2020

Background: Contraceptive use in Indonesia was still dominated by short-term contraception. Thus, Family Planning Village is created for promoting a Long-Term Contraception Method (LTCM).Aim: This study analyzed the implementation of the Family Planning Village Program for LTCM use in Dukuhsia Rambipuji, Jember.Method: This study was descriptive with a mixed-method approach. All of LTCM users in Dukuhsia amounting to 24 participated in the quantitative study. While there were five informants who were selected purposively in the qualitative research, including a Family Planning field worker, Coordinator of Women Empowerment, Child Protection and Family Planning Office, a midwife, Advocate Assistant for Village Family Planning, and a cadre under the Advocate Assistant for Village Family Planning. Qualitative data were obtained through in-depth interviews while quantitative data through structured interviews using questioner. Data were then analyzed using the Miles and Huberman Models and statistical-descriptive analysis.Results: Most aspects of the input factor were not in accordance with the technical guidelines of Family Planning Village. Whereas the implementation method complies with the guidelines. Most aspects of the process factor were relevant to the guidelines, but there were still many obstacles in the implementation. Good participation in the family planning village program is only 37.5%. Since the program launch, the prevalence of long-term contraceptive use increase from 6.07% to 6.21%. However, it does not significantly increase the use of LTCM because the prevalence was much smaller than the prevalence of LTCM at the village level.Conclusion: The implementation of the Family Planning Village in Dukuhsia could increase LTCM users. However, it could not increase the ideal proportion of LTCM users. Therefore, it is necessary to improve input and process of the Family Planning Village through the Contraceptive Technology Update (CTU) training for midwives and conduct a training of LTCM use for cadres to enhance their communicative skill in campaigning the use of LCTM.Keywords: users, contraception, family planning village, implementation.
Perjanjian Pengusahaan Tanah Perkebunan yang Dikuasai Badan Hukum Oleh Pihak Ketiga
Authors: Nurtama Iqra Elma
Published: May 2020

Salah satu kewajiban perusahaan perkebunan yang disebutkan dalam Pasal 58 UU Perkebunan menyatakan bahwa perusahaan perkebunan yang memiliki Izin Usaha Perkebunan serta Izin Usaha Budidaya wajib menyediakan fasilitas perkebunan sekitar 20% dari total luas areal yang diusahakan, untuk kemudian fasilitas perkebunan dapat dilakukan dengan sistem kemitraan dengan sistem bagi hasil ataupun bentuk perjanjian lain, pembangunan fasilitas perkebunan masyarakat seharusnya diatur lebih lanjut dalam Peraturan Pemerintah namun hingga saat ini Peraturan Pemerintah belum diterbitkan, sehingga beberapa peraturan terkait total luas fasilitas perkebunan rakyat tumpang tindih. Perusahaan perkebunan dalam mengusahakan tanah perkebunan diatur dalam Pasal 16 UU Perkebunan yang menyatakan bahwa pelaku usaha perkebunan wajib mengusahakan paling sedikit 30% dari luas tanah perkebunan dalam waktu paling lambat 3 tahun setelah pemberian hak atas tanah dan paling lambat 6 tahun setelah pemberian hak atas tanah wajib untuk diusahakan seluruh luas tanah perkebunan yang dapat ditanami tanaman perkebunan, maka dengan memperhatikan asas fungsi sosial dan pasal 15 UUPA seharusnya tanah perkebunan diatas Hak Guna Usaha dapat diperjanjikan dengan pihak ketiga, namun disebutkan dalam Pasal 12 PP No. 40 Tahun 1996 menyatakan bahwa salah satu kewajiban pemegang Hak Guna Usaha adalah mengusahakan tanah Hak Guna Usaha sendiri sesuai dengan kelayakan usaha. Berdasarkan penelitian ini menunjukkan bahwa, Perjanjian pengusahaan tanah perkebunan diatas tanah Hak Guna Usaha yang dikuasai badan hukum oleh pihak ketiga diperbolehkan sehingga tidak mengakibatkan tanah Hak Guna Usaha kembali menjadi tanah yang dikuasai negara.
Trilateration Method For Estimating Location in RSSI-Based Indoor Positioning System Using Zigbee Protocol
Authors: Pujiharsono Herryawan , Utami Duwi , Ainul Rafina Destiarti
Published: May 2020

Wireless network technology that is used today is developing rapidly because of the increasing need for location information of an object with high accuracy. Global Positioning System (GPS) is a technology to estimate the current location. Unfortunately, GPS has a disadvantage of low accuracy of 10 meters when used indoors. Therefore, it began to be developed with the concept of an indoor positioning system. This is a technology used to estimate the location of objects in a building by utilizing WSN (Wireless Sensor Network). The purpose of this study is to estimate the location of the unknown nodes in the lecturer room as an object and obtain the accuracy of the system being tested. The positioning process is based on the received signal strength (RSSI) on the unknown node using the ZigBee module. The trilateration method is used to estimate unknown node located at the observation area based on the signal strength received at the time of testing. The result shows that the path loss coefficient value at the observation area is 0.9836 and the Mean Square Error of the test is 1.251 meters, which indicates that the system can be a solution to the indoor GPS problem.
STRATEGI PEMERINTAHAN DESA SEGARAN KECAMATAN DELANGGU KABUPATEN KLATEN DALAM PEMENUHAN HAK ANAK MENUJU DESA LAYAK ANAK
Authors: Dwi Paksi Octavia Monalisa Bela , Triyanto Triyanto , Hartanto Rima Vien Permata
Published: May 2020

The aims of this research were: (1) to identify the strategies of Segaran Village Goverment to fulfill the children’s right in order to be children proper village, (2) the reveal the obstacles of Segaran Village Government to fulfill the children’s right in order to be children proper village, (3) to find out the solutions to handle the obstacles of fulfilling the children’s rights in order to be children proper village by Segaran Village Government.

This research applied a descriptive qualitative research. The sources of the data were informants, events, and documents. The sample was chosen by purposive sampling technique. The data were obtained through interview, observation, and document analysis.  The researcher triangulated the data obtained and the method used in order to have the valid data. On the other hand, the data were analyzed using interactive model, i.e.: (1) data collection, (2) data reduction, (3) data display, and (4) drawing conclusion. Meanwhile, the research was done through some procedures, namely: (1) pre-research, (2) data collection, (3) data analysis, and (4) research report writing.

According to the results of the research, it can be summed up that: (1) the strategies of Segaran Village Goverment to fulfill the children’s right in order to be children proper village are by activating BKB cadres, cooperating with some village institutions, upgrading the village infrastructure, enhancing society awarness, applying sekolah sungai programs, applying jemput bola strategy, giving the birth certificate, and allocating the fund estimation of children proper village, (2) the obstacles of the government were the lack of the society awarness about the significance of children proper programs, the lack of the society participation, and the obstruction of the fund estimation, thus, the  implementation of some programs were not done well. In addtition, some obstacles come from the dense of the society bussiness, the lack of communnication of the society and the government, and the inferiority of the society to respond the programs. The last conclusion deals with the soulution of the problems. The solution applied by the government was continous approaching to the society and arranging the priority according to its importance level. Additionally, the society keep increasing their participation to be actively involved and be open minded, critical, and smart to implement the programs of the governments.

 

Keywords: strategies,Segaran Village government, children right, children proper village.
PERAN PENDIDIKAN PANCASILA DAN KEWARGANEGARAAN DALAM BIMBINGAN KONSELING
Authors: Hidayanto Nova Eko
Published: May 2020

We know that how important BK (Counseling Guidance) in campus and secondary  school until senior high school. Remember that now is globalization or modern era which is how heavy information from foreign country that do not bring fine cases which accordance with our country personality that is Pancasila. Lately, many decadence moral like student or society fighting, drug and alcohol drinking, et cetera. Even especially many victim of alcohol drinking are student of very young people and this is become central of attention from our state, Indonesia, not only now but forever. Because of that, alcohol drinking which is easy gotten and identical with appearance of discotiques which is come from foreign country. Of course drug and alcohol drinking can cause death accordance with medical science and destroy  of education world. In one side, BK role is helping and pushing service to all student for to speed their study with giving advices so that can filter  negative acts which can not accordance with Pancasila and religion. In this, BK role must join with religion and PPKN teacher for helping better student in Indonesia.

Kata Kunci : Role, Pancasila and Civic, Counseling Guide
PENGUATAN KARAKTER BERBASIS JATI DIRI BANGSA PADA PELAJAR NAHDLATUL ULAMA DAN IMPLIKASINYA TERHADAP KETAHANAN PRIBADI PEMUDA (Studi di Pimpinan Cabang IPNU Kabupaten Karanganyar, Provinsi Jawa Tengah)
Authors: Oktofianto Dwi
Published: May 2020

This research was studied the enforcement of IPNU PC national identity character in Karanganyar towards personal resiliences members. The enforcement of character based on IPNU PC national identity in Karanganyar is useful in preserving the trust and solidarity of citizens towards the nation state. The research method used was qualitative research with phenomenology approach. Data analysis techniques used by researchers were open coding and axial coding. The results showed that the enforcement of IPNU PC identity character in Karanganyar toward personal resiliences members was done by internalizing Pancasila values in science and khataman assemblies, Makesta (Loyalty of Members), and IPNU PC National Post-Exam Guidance (BPUN) in Karanganyar. The strengthening of IPNU PC's identity character in Karanganyar toward personal endurance of members starts from the stage of understanding (understand the true), ngrasa (feel good), and nglakoni (must be implemented). The implications to be a confident human being and firmly adhered to the principle, citizens who were active in the responsibilities of society, solid citizen living in harmony and togetherness, being an open citizen on the basis of kinship.
Keywords: Character, Identity, Youth Organization and Personal Resilience.
Musician’s Hand Problems: Looking at Individuality: A Review of Points of Departure
Authors: Wagner Christoph
Published: May 2020

Various strategies on how to uncover the causation of musicians’ hand problems have been outlined. Little attention, however, has been paid to the interaction of the numerous biomechanical factors involved and the extent of their inter- and intra-individual variation. A systematic
biomechanical analysis is presented considering three basic elements: a) size and shape of the hand, b) resistance of the joints involved, and c) muscle forces acting on these joints. Results of the individual hand measurement are summarized as a “Hand Profile.” It shows the instrumentalist’s
biomechanical constellation in comparison with a control group of healthy professional musicians, serving as a base to advise musicians from a medical perspective and/or with regard to playing technique. From hand research as a whole, we may recognize that there is in fact little reason for
generalizing manual abilities.
Intervention Program in College Instrumental Musicians, with Kinematics Analysis of Cello and Flute Playing: A Combined Program of Yogic Breathing and Muscle Strengthening-Flexibility Exercises
Authors: Lee Sang-Hie , Carey Stephanie , Dubey Rajiv , Matz Rachel
Published: May 2020

College musicians encounter health risks not dissimilar to those of professional musicians. Fifteen collegiate instrumental musicians participated in the intervention program of yogic-breathing and muscle-strengthening and flexibility exercises for 8 weeks. Pre- and post-intervention
data from the Health-Pain-Injury Inventory (HPI) and the Physical & Musical-Performance Efficacy Assessment Survey (PME) were analyzed for the effects of the program on the musicians’ physical and musical-performance efficacy. HPI results showed that the majority of our sample had
healthy lifestyles and minimal pain and injuries but irregular eating and exercise habits. The pre-intervention PME data showed a high level of musical efficacy (i.e., awareness of music technique, tone, and flow) but a low-level of physical efficacy (i.e., awareness of posture, tension, and
movement flexibility). Post-intervention data showed that the program improved physical efficacy by increased awareness of posture and tension. In 2 volunteer musicians, kinematics motion analysis was conducted for exploratory purposes. Our cellist played the scale using a larger range of
motion (ROM) in right shoulder flexion and abduction and slightly increased rotation while keeping decreased right elbow ROM after the intervention program. The flutist shifted the body weight from one foot to the other more in the second playing post-intervention. These changes can be attributed
to the increased physical efficacy that allowed freedom to express musicality. Findings from these case scenarios provide empirically based hypotheses for further study. We share our experience so that others may use our model and instruments to develop studies with larger samples.
Dance as an Eccentric Form of Exercise: Practical Implications
Authors: Paschalis Vassilis , Nikolaidis Michalis G , Jamurtas Athanasios Z , Owolabi Emmanuel O , Kitas George D , Wyon Matthew A , Koutedakis Yiannis
Published: May 2020

The eccentric action is an integral part of the stretch-shortening (or eccentric-concentric) cycle of muscle movement, especially when repositioning of the centre of gravity is required. Jumps and landing tasks are examples of this cycle and are incorporated in most dance activities.
However, unaccustomed eccentric muscle action can cause muscle damage, which is characterised by the development of delayed-onset muscle soreness and swelling, decline of pain-free range of motion, as well as sustained loss of muscle force and range of motion. Furthermore, unaccustomed eccentric
muscle action can induce disturbances in movement economy and energy expenditure, so dancers spend more energy during a routine than usual. Such negative effects are gradually reduced and eventually disappear due to physiological adaptations to this form of muscular activity. Given that eccentric
exercises also appear to induce greater muscle performance improvements than other forms of muscle conditioning, it is advised that they should be integrated into dancers’ weekly schedules. The purpose of the present review is to examine the possible effects of the eccentric component
of dance on the performance and health status of dancers.
Alcohol Use by Australian Actors and Performing Artists: A Preliminary Examination from the Australian Actors’ Wellbeing Study
Authors: Szabó Marianna , Maxwell Ian , Cunningham Mitchell L , Seton Mark
Published: May 2020

BACKGROUND: Anecdotal and media reports suggest that actors and performing artists are vulnerable to high levels of alcohol use. However, little empirical research is available to document the extent and correlates of alcohol use amongst these artists, particularly in an Australian
context. OBJECTIVE: This study investigated alcohol use in a sample of Australian actors and other performing artists and its associations with sociodemographic background, psychological wellbeing, and work stress. METHODS: An online survey was distributed to the Equity Foundation membership
representing Australian actors and performing artists. The survey included questions on sociodemographic and occupational background and psychological wellbeing (DASS-21), as well as the AUDIT questionnaire to assess self-reported alcohol consumption. A sample of 620 performing artists responded
to the survey, a large majority of whom were actors. RESULTS: Australian actors and performing artists appear to consume alcohol at levels that are higher than those found in the general Australian population. About 40% of men and 31% of women were classified as drinking alcohol at potentially
harmful or hazardous levels. Alcohol use was not strongly associated with age, education, or income, but it had a relationship with poorer psychological wellbeing. About 50% of respondents reported that their alcohol drinking was related to work stress as a performer. This perception was more
pronounced amongst those performers who reported drinking at harmful levels. CONCLUSIONS: Australian actors and performing artists appear to be an at-risk population for harmful or hazardous alcohol use.
Isolation and Characterization of Staphylococcus Aureus Phage and Its Anti-Biofilm Activity Individually or Collaborative with Streptomycin
Authors: Jiang Liming , Zheng Rui
Published: May 2020

Background: Staphylococcus aureus was a widespread of Gram-positive pathogen bacteria which causes a wide range of symptoms. Bacteria biofilm was the multicellular community of microorganisms that attached to non-biological and biological surfaces. Method: Here, we aimed to isolation and characterization of S. aureus phage and research its bactericidal activity that individually or collaborative with streptomycin.Results: In this study, virulent phage WX was isolated from slaughter house in Jiangsu, China. It’s belonged to the Siphoviridae family and optimal growth temperature was 37 ℃, the pH of optimal preservation buffer was 6~7, optimal multiplicity of infection (MOI) was 0.01 and the genome size was 141, 342 bp. Phage WX has can sterilize most clinical strains of S. aureus which was isolated from clinical patients in the first people's hospital of Yunnan province laboratory. Streptomycin has better anti-biofilm effect than phage WX in low concentration culture of bacteria, nonetheless, phage WX has better anti-biofilm effect than streptomycin in high concentration culture of bacteria. Collaboration of phage WX and streptomycin have better anti-biofilm effect than alone of WX or streptomycin in low concentration culture of bacteria and phage WX have better anti-biofilm effect than streptomycin in high concentration culture of bacteria. Conclusion: The data of this study provided a strong evidence of application phage for reduce the growth of S. aureus biofilm, this study was important for clinic and replace antibiotics in some extent.
Stand structural diversity and species with leaf nitrogen conservative strategy drive aboveground carbon storage in tropical old-growth forests
Authors: Wang Genzhu , Liu Yuguo , Wu Xiuqin , Pang Danbo , Yang Xiao , Hussain Azfar , Zhou Jinxing
Published: May 2020

Background: Tropical old-growth forest ecosystems are essential for global carbon regulation. Even there are mounting evidences for the significance of species and functional composition, stand structure and elevation gradients on aboveground carbon storage, the relative strengths of these drivers and whether elevation effects via biotic factors are not clear. Furthermore, the mechanisms (the mass-ratio hypothesis or niche complementarity hypothesis) are still poorly understood.Methods: We analyzed aboveground carbon storage, species diversity, stand structural diversity, community-weighted mean (CWM) of functional traits and functional diversity (FDvar) using date from 56 old-growth forest communities with different elevation gradients in Dawei mountain of southwestern China. Multiple regression models were used to test the relative importance of the predictor variables and structural equation model was used to explore the direct and indirect influences on the aboveground carbon storage.Results: Our optimal multiple regression model show aboveground carbon storage is mostly affected by diameter at breast height (DBH) diversity, followed by FDvar of dry matter concentration in mature leaves and CWM nitrogen concentration in young leaves. The final structural equation model indicates elevation indirectly affected aboveground carbon storage via DBH diversity. The stand structural diversity, but not species diversity or functional diversity, enhanced aboveground carbon storage.Conclusions: Our results indicate mass-ratio and niche complementarity effect promote aboveground carbon storage simultaneously. The complex stand structure and species with leaf nitrogen conservative strategy were the crucial drivers of aboveground carbon storage in tropical old-growth forests.
Deciphering miRNAs involved in crosstalk between auxin and cold stress in Arabidopsis roots
Authors: Aslam Mohammad , Sugita Kenji , Qin Yuan , Rahman Abidur
Published: May 2020

The phytohormone auxin and microRNA-mediated regulation of gene expressions are key regulators for plant growth and development at both optimal and under low-temperature stress conditions. However, the mechanistic link between microRNA and auxin in regulating plant cold stress response remains elusive. To better understand the role of microRNA in the crosstalk between auxin and cold stress responses, we took advantage of the mutants of Arabidopsis thaliana with altered response to auxin transport and signal. Screening of the mutants for root growth recovery after cold stress at 4°C revealed that the auxin signaling mutant, solitary root 1 ( slr1; mutation in Aux/IAA14), shows a hypersensitive response to cold stress. Genome-wide expression analysis of miRNA in wild-type and slr1 mutant roots using next-generation deep sequencing revealed 180 known and 86 novel cold-responsive microRNAs. Cold stress also increased the abundance of 26nt-31nt small RNA population in slr1 compared with wild-type. Comparative analysis of microRNA expression shows differential expression of 13 miRNAs in slr1 compared with wild-type. Target gene expression analysis of one of the potential candidate miRNAs, miR169 revelaed the possible involvement of miR169- NF-YA module in the auxin-mediated cold stress response. Taken together, these results indicate that SLR/IAA14, a transcriptional repressor of auxin signaling, plays a crucial role in integrating miRNA in auxin and cold responses.
Identification of Mitochondrial-related Prognostic Biomarkers Associated with Metabolic Processes of Hepatocellular Carcinoma
Authors: Zhang Tao , Nie Yingli , Cai Kailin , Chen Xiangdong , li huili , Wang Jiliang
Published: May 2020

Background

Hepatocellular carcinoma (HCC) is one of the leading causes of tumor-associated deaths worldwide. Despite the great progress in early diagnosis and multidisciplinary tumor management, the long-term prognosis of HCC remains unfavorable. Currently, metabolic reprogramming is widely found during tumor development to satisfy the growth and proliferation of cancer cells. And several metabolic targets have been identified and used as cancer biomarkers. Liver and mitochondrion are the two hubs of metabolism in humans in the organic and cellular levels, respectively. Thus, identifying prognostic biomarkers in mitochondrial-related genes (Mito-RGs) that reflect the metabolic alteration of HCC could lead to better interventions for HCC patients.
Methods

mRNA expression profiles and clinicopathological data of hepatocellular carcinoma (HCC) were obtained from The Cancer Genome Atlas (TCGA) database and Mito-RGs were obtained from mSigDB database. Weighted gene coexpression network analysis (WGCNA) was used to identify the interesting gene module that associated with HCC prognosis. Based on a univariate and the least absolute shrinkage and selection operation (LASSO) Cox regression analyses, a Mito-RGs based classifier was established and used for predicting the overall survival (OS) in HCC patients. Receiver operating characteristic (ROC) curve and multivariate Cox regression analysis were used to evaluate the prognosis performance of our classifier. Gene Set Enrichment Analysis (GSEA), Gene Set Variation Analysis (GSVA) and Consensus ClusterPlus algorithms were used to identify metabolic pathways that were significantly different between the high and low-risk groups based on the risk score calculated by the classifier.
Results

We constructed a classifier containing 10 Mito-RGs (ACOT7, ADPRHL2, ATAD3A, BSG, FAM72A, PDK3, PDSS1, RAD51C, TOMM34, and TRMU) for predicting the prognosis of HCC. And the classifier is an independent prognostic signature in predicting HCC patients' survival. Besides, the metabolic processes about fatty acid, amino acid, and bile acid were significantly downregulated in high-risk group, which may play notable roles in the development and unfavorable prognosis of HCC.
Conclusion

The Mito-RGs based classifier could act as an independent biomarker for survival prediction of HCC patients. Moreover, our research may provide a novel method for HCC metabolic therapy based on the modulation of mitochondrial function.
KLF5-mediated Eppk1 expression promotes cell proliferation in cervical cancer via the p38 signaling pathway
Authors: Pan Zhe , Liu Xiao , Chang Quan , Zhang Jin-jin , Hua Na , Li Guo-Hua , Ma Dong
Published: May 2020

Background: Epiplakin1 (Eppk1) is part of the EGF signal and is involved in cytoskeleton reorganization and cell proliferation. However, the role of Eppk1 in cervical cancer remains unknown.Objective: To determine the role of EPPK1 on cell proliferation in cervical cancer.Methods: The expression of Eppk1 and KLF5 as well as their correlation were assessed by RNA-seq, qRT-PCR, TCGA database and immunofluorescence staining. In CC cell lines, adenovirus-mediated overexpression or knockdown of KLF5 and Eppk1 as well as corresponding assessment of cell proliferation and signaling were determined by western blot and CCK8 experiments. Assays of lucifase reporter gene and CHIP were used to investigate mechanism between KLF5 and Eppk1.Results: Eppk1 expression was markedly in CC tissues and cell lines companied by KLF5 upregulation. The results of immunofluorescence staining further showed that the increased expression of Eppk1 and KLF5 correlated with progression of cervical tumorigenesis. Overexpression of KLF5 significantly increased Eppk1 expression at transcription and translation levels. Conversely, the knockdown of KLF5 by siRNA against KLF5 decreased Eppk1 expression. Mechanical studies showed that KLF5 activated Eppk1 transcription by direct binding to the Eppk1 promoter. Gain- and loss-of-function experiments showed that KLF5 promoted cell proliferation in Hela by upregulating Eppk1 expression. Moreover, KLF5-mediated the activation of EGFR and p38 signaling significantly decreased after Eppk1 knockdown companied with reduction of proliferating activity, suggesting that Eppk1 lies upstream of p38 signaling affecting cell proliferation in CC. Finally, the expression of Eppk1 positively correlated with tumor size.Conclusions: Eppk1 may be an effective therapeutic target on affecting EGFR-associated p38 signaling pathway and cell proliferation in cervical cancer.
Overexpression of IL-8 in patients with abdominal tumor after radiotherapy leads to ureteral obstructive renal dysfunction: a case-control study
Authors: Bai Liang , Luo Li , Gao Weicheng , Bu Chenfeng , Li Jun , Liu Huang
Published: May 2020

Purpose: To analyze the expression of interleukin-8 in patients with post-renal insufficiency after radiotherapy of abdominal tumors.Methods: 60 patients (experimental group) with post-renal insufficiency and 30 patients (control group) without renal insufficiency after the radiotherapy for abdominal tumors were collected for case-control study. Serum interleukin-8 levels were measured before and after the cystoscopy from September 2017 to March 2019, and the relationship between interleukin-8 levels and serum creatinine, and urea nitrogen, and hydronephrosis was analyzed.Results: The level of serum interleukin-8 levels were significantly increased in patients with post-renal insufficiency after radiotherapy for abdominal tumors(P<0.05).After treatment, the level of interleukin-8 in the experimental group was significantly lower than that before the treatment (P<0.05). The expression of interleukin-8 was positively correlated with serum creatinine (r=0.297, P=0.004), but not with urea nitrogen level and hydronephrosis (r1=-0.055, P1=0.605; r2=0.116, P2=0.277). Cox proportional risk regression model showed that interleukin-8 was a high risk factor for the occurrence of post-renal insufficiency (R2=0.826, P<0.05).Conclusion: Interleukin-8 is helpful to judge the renal function of patients with abdominal tumors after radiotherapy, In the early stage of renal insufficiency, it will overexpresses, and its evaluation is better than urea nitrogen.
Chromatin structure changes in Daphnia populations upon exposure to environmental cues – or – The discovery of Wolterecks “Matrix”
Authors: AUGUSTO Ronaldo de Carvalho , Minoda Aki , Rey Oliver , Cosseau Celine , Chaparro Cristian , Vidal-Dupiol Jeremie , Allienne Jean-Francois , Duval David , Pinaud Silvain , Tönges Sina , Andriantsoa Ranja , Luquet Emilien , Aubret Fabien , Sow Mamadou Dia , David Patrice , Thomson Vicki , Joly Dominique , Lima Mariana Gomes , Federico Deboraj , Danchin Etienne , Grunau Christoph
Published: May 2020

Background: This study therefore describes the classical experimental system postulated by Richard Woltereck 100 years ago: the adaptive morphological phenotypic plasticity of daphnia . Phenotypic plasticity is an important feature of biological systems that is likely to play a major role in the adaptation of organisms exposed to an environmental stimulus and it is increasingly related to epigenetic mechanisms. Several studies have started to identify the epigenetic basis of phenotypic plasticity of daphnia including non-coding RNAs, covalent modifications at the histone tails and DNA methylation however no study has yet investigated those effect on the genome-wide chromatin structure. The aim of this work was to study for the first time the overall genome-wide chromatin structure of Daphnia pulex in the context of the iconic complex defense response to predation. We developed a robust and rapid ATAC-seq technique that allows for analyzing chromatin of individual daphnia and show here (i) that this technique can be used with minimal expertise in molecular biology, and (ii) we used it to identify open chromatin structure in daphnia exposed to different environmental cues.Results: Our results encouraged the expected induction of anti-predatory morphological changes in the stress treatment was significantly higher than that of daphnia from the control treatment. The developed ATAC-seq technique can be used to characterize chromatin structures of individuals even those that are small and thus with few biological material, making it possible to determine epigenetic polymorphisms relatively easily and at reasonable cost in full populations. In addition, we deliver evidence that chromatin structure changes upon stimuli from the environment.Conclusion: We report here an extremely fast and straightforward method to map the chromatin status of individuals using small amounts of input biological material. W e show here that changes in the environment, such as predator presence the chromatin structure is profoundly reorganised confirming Woltereck ’s classical postulate.
Acutely Altered Mental Status as the Main Clinical Presentation of Multiple Strokes in Critically Ill Patients With COVID-19.
Authors: Díaz-Pérez Carolina , Ramos Carmen , López-Cruz Alberto , Olmedo José Muñoz , González Jimena Lázaro , de Vega-Ríos Enrique , González-Ávila Carmen , Hervás Carlos , Trillo Santiago , Vivancos José
Published: May 2020

Background and aims:Cerebral infarction in COVID-19 patients might be associated with a hypercoagulable state related to a systemic inflammatory response. Its diagnosis might be challenging. We present two critically ill patients with COVID-19 who presented acutely altered mental status as the main manifestation of multiple strokes.Methods:Clinical presentation and diagnostic work-up of the patients.Results:Two patients in their sixties were hospitalized with a bilateral pneumonia COVID-19. They developed respiratory failure and were admitted to ICU for mechanical ventilation and intense medical treatment. They were started on low-molecular-weight heparin since admission. Their laboratory results showed lymphopenia and increased levels of C-reactive protein and D-dimer. Case 1 developed hypofibrinogenemia and presented several cutaneous lesions with biopsy features of thrombotic vasculopathy. Case 2 was performed a CT pulmonary angiogram at ICU showing a bilateral pulmonary embolism. When waking up, both patients were conscious but with a remarkable global altered mental status without focal neurological deficits. A brain MRI revealed multiple acute bilateral ischemic lesions with areas of hemorrhagic transformation in both patients (Case 1: affecting the left frontal and temporal lobes and both occipital lobes; Case 2: affecting both frontal and left occipital lobes). Cardioembolic source and acquired antiphospholipid syndrome were ruled out. COVID-19-associated coagulopathy was suspected as the possible main etiology of the strokes.Conclusion:Acutely altered mental status might be the main manifestation of multiple brain infarctions in critically ill COVID-19 patients. It should be specially considered in those with suspected COVID-19-associated coagulopathy. Full-dose anticoagulation and clinical-radiological monitoring might reduce their neurological consequences.
THE ROLE OF INTERNATIONAL AGREEMENTS IN CLIMATE POLICY
Authors: Szira Zoltán , Alghamdi Hani
Published: May 2020

Climate change is one of the greatest environmental challenges of our time. Climate change can occur as a result of natural processes on Earth (e.g., tectonic motion of continents), as a result of external influences on the planet (e.g., changes in the intensity of solar radiation), or even as a result of human activity (e.g., greenhouse gas production). Human activities have boosted emissions of carbon dioxide, pushing up the temperatures. One potential impact is extreme weather and melting polar ice. There are natural climate fluctuations, but it is a fact that temperatures are growing higher now than at many other periods. This is related to the greenhouse effect which describes how some of the Sun's energy is trapped in the Earth's atmosphere. Solar energy from the Earth's surface, radiating back to space, is absorbed by greenhouse gases and re-emitted in every direction. This present paper discusses the impact of climate change and summarises the role of legal regulations in the process of this major environmental problem.
INVESTIGATION OF FORMATION OF THE SOCIAL READINESS TO STUDYING AT SCHOOL IN SENIOR PRESCHOOL CHILDREN WITH MODERATE INTELLECTUAL DEVELOPMENT DISORDERS
Authors: Chobanian Аnnа , Kolyshkina Alla , Kolyshkin Oleksandr
Published: May 2020

The authors of the paper consider the problem of social formation of senior preschool children with moderate intellectual development disorders as a precondition of studying at school. The problem is solved in the aspect of general favoring social development of this category of children, namely formation of soft-skills in preschool children with intellectual development disorders. The theoretical-analytical work of studying the problem of formation of the social readiness of senior preschool children with moderate intellectual development disorders was based on the diagnostics of the social readiness to studying at school of this category of children and two components in its structure (communicative and social competences), which content includes criteria (cognitive-motivational; behavioral; cognitive; operational), indicators and their levels were determined. The formation of the social readiness of children with moderate intellectual development disorders to studying at school was investigated competence by competence (social and communicative competences), taking into account the comparative principle by juxtaposing their results with ones of children with light intellectual development disorders. There was empirically revealed the low formation level of the social readiness of senior preschool children with moderate intellectual development disorders that is conditioned by an insufficient formation level of its structural components: social – at the expanse of low indicators of understanding him/herself as a member of a social group by a child, non-formation of the ability to perceive and produce information about him/herself, own inclinations, significant adults, inability to observe social norms and values in behavior and interaction with others, rigidity of behavioral strategies at interaction with others, non-conformity of reaction to their words and actions, non-formation of the ability to listen, not to interrupt; communicative – because of difficulties to understand addressed speaking, inability to enter the communication process, non-formation of knowledge about communication culture rules in relation with coevals and adults, absence of self-control/mutual control in communication situations, non-formation of the ability to correlate verbal communication means with nonverbal ones.
The Problem of Identity and Transculturalism in the Works of Seyran Ates
Authors: Mikhaleva Albina
Published: May 2020

With its extensive experience in public debate about Leitkultur and multiculturalism, Germany still faces the need for a unifying identification model that would suit both the Germans and the immigrant community. This article considers the socio-political views of Seyran Ates, a female imam and the founder of the Liberal Mosque in Berlin, on cultural identity, Leitkultur, and integration in Europe. The author used the biographical approach and the method of text analysis of monographs, articles, and interviews with S. Ates. The analysis revealed a hierarchical two-component identity structure with a priority of European Leitkultur. Despite the declarative commitment to the transcultural approach, S. Ates is in fact inclined towards a simple mix of cultures. The process of convergence between migrants and the host society, which she does not want to describe in terms of integration, does not receive any other conceptual framework and remains theoretically unclear. One can only guess about its components from her speculations about transcultural identity. However, a simple coexistence in different cultural forms does not reveal the process of transformation at the subject level, but leaves a feeling of cultural chaos.
Setting and Implementing Sustainable Development Goals on the Regional Level: the Case of Kuzbass
Authors: Shut'ko Larisa , Samorodova Lyudmila
Published: May 2020

The research features integration of Russian economy into the model of sustainable development proposed by the United Nations Organization. The authors considered the main goals of sustainable development and their prospects in Russia. The paper focuses on the case of Kuzbass (Kemerovo region) as a typical resource-type mining region. The authors studied how the local authorities implement the sustainable development concept, solve demographic problems, preserve biodiversity, and protect forests. The research involved elements of systematic and integrated approach. The authors believe that the sustainable development of a mining region depends on the implementation of the best available technologies, energy efficiency, creating green spaces, and production safety. The research also featured the role of coal mining enterprises in the formation of the regional model of sustainable development and achieving the main target priorities of sustainable development in accordance with the UN Program. The article describes the roadmap of the sustainable development model for Russian territories, as well as regional national projects, e.g. digital platforms in coal mining and environmental protection. The authors emphasize the need for reclamation of disturbed lands by coal mining companies.
ACUTE EFFECTS OF KINESIOTAPING ON BALANCE IN SALSA DANCERS
Authors: AYBERK Bahar , UYSAL Hakan
Published: May 2020

Purpose: Non-professional salsa dance is a social, physical activity highly in demand. Since it is a vigorous physical activity, dancers are prone to have an injury during a dance performance, mainly in the ankle joint. In this study, the acute effects of kinesiotaping (KT) on balance in salsa dancers were investigated. Methods: This study was a single-blind randomized placebo-controlled trial, in which a total of 20 amateur salsa dancers (mean age=26.35±4.74 years), voluntarily participated. Participants were divided into two groups randomly by using a sealed envelope randomization method: KT Group (n=10) and Placebo-KT Group (n=10). A muscle correction technique that covers the ankle and peroneal muscle group were applied to KT Group one day after pre-tests. An "I" shaped placebo KT application was performed for the Placebo-KT Group. Flamingo balance test (FBT) and the Star Excursion Balance Test (SEBT) were used to assess balance performance. All tests were repeated immediately after the application. Results: In the intragroup analysis of the KT Group, SEBT scores showed a statistically significant increase (p<0.05) while there was no increase in FBT scores (p>0.05). We found no statistically significant difference in the intragroup analysis of Placebo-KT Group and the intergroup analysis of KT Group and Placebo-KT Group for both SEBT and FBT scores (p>0.05). Conclusion: While KT application has been found to be effective in improving dynamic balance, it was not effective in improving static balance performance.
Leakage reduction in WDNs through optimal setting of PATs with a derivative-free optimizer
Authors: Cimorelli Luigi , D'Aniello Andrea , Cozzolino Luca , Pianese Domenico
Published: May 2020

Excessive pressure in water distribution networks (WDNs) may lead to undesirable effects, such as increased pipe failure rate and leakages. Pressure management (PM) techniques are indeed attractive to address these issues, reducing energy and water losses. Among the most recent PM techniques, pumps working as turbines (PATs) can be employed to both control pressure and recover energy. However, finding the best location, setting, and number of PATs to maximize both leakage reduction and energy production within a WDN is particularly challenging due to the severe nonlinearity of the problem and the large number of decision variables. To address the setting problem, a promising derivative-free nonlinear programming method is herein presented. The proposed method, modified to account for bound-type constraints, is capable of finding the optimal setting of a chosen number of PATs, given their position, direction, and machine type (characteristic curve), accounting for both energy and saved water volumes costs. In addition, this method is also able to establish whether the installed PATs must be bypassed or not. The proposed method capabilities are tested on a hypothetical complex WDN taken from the literature.
Simulação na formação e na qualificação do profissional de enfermagem
Authors: Vargas Mara Ambrosina de Oliveira
Published: May 2020

Simulação é uma pedagogia que utiliza um ou mais estratégias para promover, melhorar ou validar conhecimentos, dos participantes por meio da aprendizagem baseada na experiência.
CARGA DE TRABALHO E DIMENSIONAMENTO DE PESSOAL DE ENFERMAGEM EM TERAPIA INTENSIVA NEONATAL
Authors: Grebinski Ana Tamara Kolecha Giordani , Biederman Francislene Aparecida , Berte Caroline , Barreto Grasiely Masotti Scalabrin , De Oliveira João Lucas Campos , Dos Santos Elba Bispo
Published: May 2020

Objetivo: Mensurar a carga de trabalho da equipe de enfermagem de uma Unidade de Terapia Intensiva Neonatal (UTIN) e dimensionar o quadro de pessoal necessário para o suprimento desta demanda. Metodologia: Estudo transversal, documental e quantitativo. Foram coletadas variáveis de caracterização clínica e demográfica da amostra (n=105) de recém-nascidos e da carga de trabalho da enfermagem por meio do Nursing Activities Score (NAS). O dimensionamento foi calculado com base em equação para terapia intensiva e ajustado à Resolução nº 543/2017 do Conselho Federal de Enfermagem. Resultados: A média do NAS da UTIN foi de 749,9. Obteve-se quadro dimensionado de 43 profissionais, com déficit de 17 enfermeiros em comparação ao quadro disponível. Conclusão: O quadro de enfermeiros da UTIN é insuficiente.Descritores: Carga de trabalho; Dimensionamento; Equipe de enfermagem; Unidades de terapia intensiva neonatal.WORKLOAD AND SIZING OF THERAPY IN NURSING STAFF INTENSIVE NEWBORNObjective: To measure the workload of the nursing team of a Neonatal Intensive Care Unit (NICU) and to size the personnel needed to supply this demand. Method: Cross-sectional, documentary and quantitative study. Clinical and demographic characterization variables of the sample (n = 105) of newborns and the nursing workload were collected through the Nursing Activities Score (NAS). The design was calculated based on a formula for intensive therapy and adjusted to Resolution 543/2017 of the Federal Nursing Council. Results: The mean of the NICU NAS was 749.9. It was obtained a dimensioned picture of 43 professionals, with a deficit of 17 nurses in comparison to the available picture. Conclusion: Nurses from the NICU are insufficient.Descriptors: Workload; Sizing; Nursing team; Neonatal intensive care units.CARGA DE TRABAJO Y DIMENSIONAMIENTO DE PERSONAL DE ENFERMERÍA EN TERAPIA INTENSIVA NEONATALObjetivo: Medir la carga de trabajo del equipo de enfermería de una Unidad de Terapia Intensiva Neonatal (UTIN) y dimensionar el cuadro de personal necesario para el aprovisionamiento de esta demanda. Metodologia: Estudio transversal, documental y cuantitativo. Se recogieron variables de caracterización clínica y demográfica de la muestra (n = 105) de recién nacidos y de la carga de trabajo de la enfermería por medio del Nursing Activities Score (NAS). El dimensionamiento fue calculado con base en fórmula para terapia intensiva y ajustado a la Resolución 543/2017 del Consejo Federal de Enfermería. Resultados: El promedio del NAS de la UTIN fue de 749,9. Se obtuvo un cuadro dimensionado de 43 profesionales, con déficit de 17 enfermeros en comparación al cuadro disponible. Conclusión: El cuadro de enfermeros de la UTIN es insuficiente.Descriptores: Carga de trabajo; Dimensionamiento; Equipo de enfermería; Unidades de terapia intensiva neonatal.