bluuebunny/crossref_metadata_2025 huggingface dataset:
Sedación administrada por médicos generales para procedimientos endoscópicos de baja complejidad: experiencia en una unidad de endoscopia de una clínica de alta complejidad en Cali
Authors: Sepulveda Copete Mauricio , Rojas Rojas Nelson Enrique , Herrera Lara Emiro Fernando , Sánchez Londoño Santiago , Pérez Juan Sebastian , Castaño Casas Juan Pablo , Garcia Navarrete Mario Enrique , Tobón Guevara Angelica , Garcia Abadía Jairo Alberto , Jimenez Rivera Diego Fernando , Maldonado Gutiérrez Catalina , Billefals Einer Sten , Rojas Rodríguez Carlos Arturo
Published: September 2022

Objetivos: en Colombia se ha venido implementando la sedación por médicos no anestesiólogos para procedimientos endoscópicos fuera del quirófano. Se describió la experiencia en la unidad de gastroenterología de una clínica de alto nivel de atención en Cali, Colombia.
Materiales y métodos: estudio observacional, de tipo cohorte analítica para describir la frecuencia y el tipo de eventos adversos asociados a los procedimientos de sedación por médicos generales, y evaluar los factores asociados a su ocurrencia en pacientes que acudieron a la unidad de endoscopia de la Fundación Valle del Lili para la realización de estudios endoscópicos bajo sedación intravenosa que, por ser de bajo riesgo, fue aplicada por un médico no anestesiólogo entre noviembre de 2018 y junio de 2019. Se realizó análisis descriptivo, se calcularon mediana y rango intercuartílico para las variables numéricas, y frecuencias para las variables cualitativas.
Resultados: se incluyeron 1506 participantes, 59,4 % ASA I y 40,6 % ASA II. En promedio, la dosis inicial de propofol fue de 60 mg y la dosis total, de 140 mg. Se registraron eventos adversos no serios en 46 pacientes (3,05 %) y el más común fue la desaturación transitoria (80,4 %). Ningún paciente presentó eventos adversos serios. El puntaje inicial promedio de la escala de Aldrete fue 8, mientras que al alta el puntaje promedio fue de 10.
Conclusiones: la sedación para procedimientos endoscópicos dada por médicos no anestesiólogos es segura, siempre y cuando sea realizado por personal entrenado que realice una adecuada valoración de los antecedentes (cardiovasculares, gastrointestinales y neurológicos) y factores de riesgo del paciente dentro del marco de los lineamientos institucionales vigentes.
Localized primary malignant pericardial mesothelioma: a special diagnostic method for rare diseases
Authors: Zhang Yan , Li Ziqi , Pang Mingjie
Published: September 2022

Primary malignant pericardial mesothelioma (PMPM) is a rare pericardial
malignant tumor. Most of the manifestations are localized or diffuse
masses surrounding the heart. Because of the difficulty of surgical
resection, the prognosis of diffuse PMPM is poor, while the edge of
localized PMPM is clear and easy to be resected, but it is difficult in
diagnosis Timely diagnosis and proper treatment are the key to a good
prognosis. Here, we report a patient with localized PMPM and describe
the diagnostic method for the diagnosis of the disease.
Facile preparation of zinc nanoparticles mediated by plant aqueous extract and assessment of the antioxidant, cytotoxicity and anti-human gastric carcinoma properties
Authors: Fang Huang
Published: September 2022

In this study, the Zn nanoparticles was synthesized using the peel
extract of Citrus aurantium. The nanoparticles was characterized by
different chemical technique including UV-Vis. and FT-IR spectroscopy,
and SEM technique. The results revealed a spherical shape in the average
‎size of 41.17 nm was identified for the green-synthesized
nanoparticles. In the antioxidant test, the IC50 of nanoparticles and
BHT against DPPH free radicals were 115 and 96 µg/mL, respectively. In
the cellular and molecular part of the recent study, the treated cells
with nanoparticles were assessed by MTT assay for 48h about the
cytotoxicity and anti-human gastric cancer properties on normal (HUVEC)
and gastric cancer cell lines i.e. NCI-N87 and MKN45. The IC50 of
nanoparticles were 278 and 256 µg/mL against NCI-N87 and MKN45 cell
lines, respectively. The viability of malignant gastric cell line
reduced dose-dependently in the presence of Zn nanoparticles. It seems
that the anti-human gastric cancer effect of recent nanoparticles is due
to their antioxidant effects. After evaluating the effectiveness of this
formulation in clinical trial researches, it can be a good alternative
to chemotherapy drugs.
The enhancing effect of 5-HT on phasic contractions of human isolated distal ureter and possible mediating mechanisms
Authors: ding ning , liu jianing , Zhao Mengmeng , liu lei , liu hanwen , song wei , yan jieke , wen jiliang , zu shulu , Li Yan , Shi Benkang , liu jiaxin , Xu Yang , Zhang Xiulin
Published: September 2022

Abstract Background and purpose: 5-Hydroxytryptamine (5-HT) can enhance
human ureteral contractions. However, the mediating receptors have not
been clarified yet. The study sought to further characterize the
mediating receptors using several more selective antagonists and
agonists. Experimental approach: Human distal ureters were obtained from
88 patients undergoing cystectomy. The mRNA expression levels of 5-HT
receptors were examined using RT-qPCR experiments. The phasic
contractions of ureter strips, either spontaneous or evoked with
neurokinin, were recorded in an organ bath. Key results: Among the 13
5-HT receptors, 5-HT2A and 5-HT2C had the highest mRNA expression
levels. 5-HT (10-7–10-4 M) concentration-dependently increased the
frequency and baseline tension of phasic contractions. However, a
tachyphylaxis effect was observed. SB242084 (100 nM) and ketanserin (100
nM), which are 5-HT2C selective and non-selective antagonist,
respectively, shifted the 5-HT concentration-response curves (frequency
and baseline tension) rightward. 5-HT2C selective agonist, vabicaserin,
increased contraction frequency with an Emax of 35% of 5-HT. 5-HT2A
selective antagonist, volinanserin (100 nM), only reduced baseline
tension. The selective antagonists of 5-HT1A,1B, 1D, 2B, 3, 4, 5, 6, and
7 had no antagonism. Blockade of voltage-gated sodium channels,
α1-adrenergic receptors, adrenergic neurotransmission, and neurokinin-2
receptors using tetrodotoxin, tamsulosin, guanethidine, and Men10376,
respectively, and desensitizing sensory afferents using capsaicin (100
μM), significantly reduced 5-HT effects. Conclusion and implications:
5-HT enhanced ureteral phasic contractions mainly by activating 5-HT2C.
Activation of sympathetic nerve and sensory afferents partly contributed
to 5-HT effects. 5-HT and 5-HT2C receptors could be promising targets
for ureteral stone expulsion and ureteral colic relief.
Analysis of the surface water/groundwater interaction using the gas tracers during a dynamic test: a case of induced infiltration from the river in the piedmont area
Authors: Kotowski Tomasz , Najman Joanna , Nowobilska-Luberda Aleksandra , Bergel Tomasz , Kaczor Grzegorz
Published: September 2022

We discuss a study that aimed to understand the genesis and inflow
conditions of abstracted water by intake with induced infiltration
located at a mountain river. A simple approach based on a combination of
two research techniques was used: two-component water mixing modelling
and studies of the variability of concentrations of environmental
tracers in a dynamic test. This approach is versatile, easy to apply and
modify, and can be good method for controlling surface/groundwater
interactions. We used the gas tracers because gas exchange and
dissolution of gases in infiltrating rainwater gives it a unique gas
signature that is largely retained in groundwater. We focus on
understanding river/aquifer interactions at the scale of reach of an
intake. To understand these issues, a two-day field hydrogeological
experiment based on a pumping test of increasing intensity was
conducted. At each pumping stage, groundwater and river samples were
collected to determine the concentration of noble gases, CFCs, SF6,
stable isotope content, and chemical composition of the water. The study
results indicate a short pressure propagation time between the intake
and the river, which results in inflow of water already at low water
abstract by the intake. Despite limited river water inflow, there was a
continuous hydraulic contact river/aquifer, largely independent of
changes in pumping intensity. As pumping intensity increased, the
river/aquifer hydraulic system tended towards stabilised conditions of
mixing and inflow to the intake. In general, a small proportion of river
water (up to 26%) was found in the exchange flux between the river and
groundwater.
Nearest close friend query in road-social networks
Authors: Chen Zijun , Jiang Ruoyu , Liu Wenyuan
Published: September 2022

Nearest close friend query (k?NCF) in geo-social networks, aims to find the k nearest user objects from among the ?-hop friends of the query user. Existing efforts on k?-NCF find the user objects in the Euclidean space. In this paper, we study the problem of nearest close friend query in road-social networks.We propose two methods. One is based on Dijkstra algorithm, and the other is based on ISLabel. For the Dijkstra-based method, Dijkstra algorithm is used to traverse the user objects needed. For the label-based method, we make use of IS-Label to calculate the distance between two vertices to avoid traversing the edges that do not contain the desired user object. For each method, we propose effective termination conditon to terminate the query process early. Finally, we conduct a variety of experiments on real and synthetic datasets to verify the efficiency of the proposed methods.
A novel deep LeNet-5 convolutional neural network model for image recognition
Authors: Zhang Jingsi , Yu Xiaosheng , Lei Xiaoliang , Wu Chengdong
Published: September 2022

At present, the traditional machine learning methods and convolutional neural network (CNN) methods are mostly used in image recognition. The feature extraction process in traditional machine learning for image recognition is mostly executed by manual, and its generalization ability is not strong enough. The earliest convolutional neural network also has many defects, such as high hardware requirements, large training sample size, long training time, slow convergence speed and low accuracy. To solve the above problems, this paper proposes a novel deep LeNet-5 convolutional neural network model for image recognition. On the basis of Lenet-5 model with the guaranteed recognition rate, the network structure is simplified and the training speed is improved. Meanwhile, we modify the Logarithmic Rectified Linear Unit (L ReLU) of the activation function. Finally, the experiments are carried out on the MINIST character library to verify the improved network structure. The recognition ability of the network structure in different parameters is analyzed compared with the state-of-the-art recognition algorithms. In terms of the recognition rate, the proposed method has exceeded 98%. The results show that the accuracy of the proposed structure is significantly higher than that of the other recognition algorithms, which provides a new reference for the current image recognition.
A new frog leaping algorithm-oriented fully convolutional neural network for dance motion object saliency detection
Authors: Lyu Yin , Zhang Chen
Published: September 2022

Image saliency detection is an important research topic in the field of computer vision. With the traditional saliency detection models, the texture details are not obvious and the edge contour is not complete. The accuracy and recall rate of object detection are low, which are mostly based on the manual features and prior information. With the rise of deep convolutional neural networks, saliency detection has been rapidly developed. However, the existing saliency methods still have some common shortcomings, and it is difficult to uniformly highlight the clear boundary and internal region of the whole object in complex images, mainly because of the lack of sufficient and rich features. In this paper, a new frog leaping algorithm-oriented fully convolutional neural network is proposed for dance motion object saliency detection. The VGG (Visual Geometry Group) model is improved. The final full connection layer is removed, and the jump connection layer is used for the saliency prediction, which can effectively combine the multi-scale information from different convolution layers in the convolutional neural network. Meanwhile, an improved frog leaping algorithm is used to optimize the selection of initial weights during network initialization. In the process of network iteration, the forward propagation loss of convolutional neural network is calculated, and the anomaly weight is corrected by using the improved frog leaping algorithm. When the network satisfies the terminal conditions, the final weight is optimized by one frog leaping to make the network weight further optimization. In addition, the new network can combine high-level semantic information and low-level detail information in a data-driven framework. In order to preserve the unity of the object boundary and inner region effectively, the fully connected conditional random field (CRF) model is used to adjust the obtained saliency feature map. In this paper, the precision recall (PR) curve, F-measure, maximum F-measure, weighted F-measure and mean absolute error (MAE) are tested on six widely used public data sets. Compared with other most advanced and representative methods, the results show that the proposed method achieves better performance and it is superior to most representative methods. The presented method reveals that it has strong robustness for image saliency detection with various scenes, and can make the boundary and inner region of the saliency object more uniform and the detection results more accurate.
Crowdsourcing platform for QoE evaluation for cloud multimedia services
Authors: Laghari Asif , He Hui , Khan Asiya , Laghari Rashid , Yin Shoulin , Wang Jiachi
Published: September 2022

This paper presents a novel web-based crowdsourcing platform for the assessment of the subjective and objective quality of experience (QoE) of the video service in the cloud-server environment. The user has the option to enter subjective QoE data for video service by filling out a web questionnaire. The objective QoE data of the cloud-server, network condition, and the user device is automatically captured by the crowdsourcing platform. Our proposed system collects both objective and subjective QoE simultaneously in real-time. The paper presents the key technologies used in the development of the platform and describes the functional requirements and design ideas of the system in detail. The system collects real-time comprehensive data to enhance the quality of the user experience to provide a valuable reference. The system is tested in a real-time environment and the test results are given in terms of the system performance. The crowdsourcing platform has new features of real-time network monitoring, the client device, and cloud monitoring, which currently has not been provided by existing web platforms and crowdsourcing frameworks. The results show that 1MB buffer is filled 100% very soon after starting watching videos from the crowdsourcing platform.
Case 3: Does This Patient Have Type 1 or Type 2 Diabetes?
Authors: Unjom Zubina , Gilden Janice
Published: September 2022

A 28-year-old Afro-Caribbean male, with no known prior medical conditions, was recently diagnosed with diabetes after a routine physical examination and blood tests done for pre-employment to prepare for a new, physically demanding job. The initial screening blood glucose level was 465 mg/dL, with an HbA1c of 8.8% (normal 4.0–6.0%). The primary care physician started him on metformin therapy at 1,000 mg twice daily and also placed a referral for dietary consultation. The patient was then referred to the endocrine clinic for further management of diabetes. He denied any symptoms of hyper- or hypoglycemia, infections, emotional or physical stress, or prior knowledge of glucose intolerance and had no family history of diabetes or other autoimmune conditions.
Case 6: New-Onset Diabetes as a Symptom of Pancreatic Adenocarcinoma
Authors: Gammoh Emily , Ulal Jagdeesh
Published: September 2022

The case subject was a 59-year-old male with no past medical history who was admitted with diabetic ketoacidosis. He gave a history of unintentional weight loss of 20 lb over 3 months, which was associated with fatigue and weakness. A couple of weeks before presentation, he started to develop polyuria and polydipsia. His family history included type 2 diabetes on his mother’s side of the family. He also had a 10-pack-year history of smoking but quit 2–3 years prior. On examination, the patient was a thin male (BMI 22 kg/m2) with stable vital signs and mild epigastric tenderness, but exam was otherwise unremarkable. Laboratory findings were significant for a bicarbonate level of 14 mEq/L, blood glucose of 312 mg/dL, acetone in the serum, and anion gap of 17 mEq/L, suggestive of ketoacidosis. HbA1c was 13.5%.
Case 8: Wolcott-Rallison Syndrome
Authors: Ozbek Mehmet , Cengiz Eda
Published: September 2022

A 28-month-old girl with a history of type 1 diabetes presented to the emergency room with fever and vomiting. She was diagnosed with type 1 diabetes at 2 months of age and had been being administered multiple daily injections of insulin. Past history was otherwise unremarkable. Family history was unknown, including history of consanguinity. Her vital signs revealed a temperature of 102.2°F, heart rate of 140 beats/min, and respiratory rate of 32/min. Her height was 2.4 ft (−4.54 standard deviation score [SDS]) and weight was 17.2 lb (−3.58 SDS). Physical examination was significant for decreased skin turgor, hyperemic pharynx, and hepatosplenomegaly (3 cm below the right costal margin).
Case 15: Euglycemic Diabetic Ketoacidosis Due to Sodium–Glucose Cotransporter 2 Inhibitor Use
Authors: Soliman Diana , Jelesoff Nicole
Published: September 2022

A 79-year-old male with type 2 diabetes diagnosed at age 49 years presented with worsening generalized weakness, subacute functional decline, nausea, vomiting, diarrhea, and decreased oral intake. He had a history of regionally advanced melanoma and hypophysitis with development of secondary adrenal insufficiency and hypothyroidism related to treatment with ipilimumab and nivolumab.
Case 27: Comorbidity of Diabetes and Systemic Lupus Erythematosus
Authors: Mankovsky Boris , Saenko Yanina
Published: September 2022

Patient N.V., a 57-year-old Caucasian female, was admitted to our hospital with chief complaints of newly developed skin lesions on the face and thorax that appeared a few weeks prior, as well high glucose levels, thirst, and polyuria.
Case 33: Detecting Patterns in Continuous Glucose Monitoring of Glucocorticoid-Treated Patients With Diabetes
Authors: Sandhu Harjyot , Gilden Janice , Wentz Lynne
Published: September 2022

A 76-year-old male with type 2 diabetes complicated by retinopathy and hypertension, with hypothyroidism and interstitial pulmonary fibrosis (requiring home oxygen therapy), underwent continuous glucose monitoring (CGM) for 2 weeks to optimize blood glucose control. The most recent HbA1c was 7.6%.
Case 36: A Case of Prolonged Hypoglycemia Due to Sulfonylurea and Concurrent Antibiotic Use
Authors: Merrill Jennifer , Spratt Susan
Published: September 2022

A 65-year-old African American female with recurrent ER+/PR+/HER2–left breast cancer with metastases to lymph nodes and bone, hypertension, dyslipidemia, and type 2 diabetes presented to the emergency department with refractory hypoglycemia.
Case 37: “Do I Really Need Insulin?” The Role of Insulin Therapy in Cystic Fibrosis–Related Diabetes (CFRD)
Authors: Kasim Nader , Moran Antoinette , Moheet Amir
Published: September 2022

A 23-year-old female with cystic fibrosis (CF) (homozygous for the F508del mutation), history of pancreatic insufficiency, and history of poor weight gain underwent an oral glucose tolerance test (OGTT) per routine screening for cystic fibrosis–related diabetes (CFRD).
Case 49: Insulin and Heroin: An Unfortunate Mix in an Overlooked Population
Authors: Ilaiwy Amro , Rowell Jennifer , Hong Beatrice
Published: September 2022

A 35-year-old woman was evaluated in the emergency department after she was found unconscious at home. Her medical history included type 1 diabetes diagnosed at the age of 10 years and managed with a Medtronic G670 insulin pump and Dexcom G6 continuous glucose monitor. She also had a known history of intravenous drug abuse.
Effects of Various Functional Monomers on Adhesion Between Immediate Dentin Sealing and Resin Cement
Authors: Pheerarangsikul N , Wayakanon P , Wayakanon K
Published: September 2022

Acidic functional monomers are crucial components in self-etch adhesive systems, with the most popular being phosphate and carboxylic methacrylates. When self-etch adhesive systems are selected as immediate dentin sealing (IDS) for an indirect restoration, they will be in direct contact with the adhesive system of the resin cement on the restoration. The purpose of this study was to compare relative bond strength produced by different combinations of IDS and adhesive system monomers in order to identify the most effective bond. Premolar teeth were divided into 13 experimental groups (n=10), each representing a particular combination of IDS monomer and resin cement monomer. The upper half of each crown was cut off horizontally to expose the dentin as a flat surface. The IDS assigned for each group was applied to the dentin and polymerized. Previously polymerized and sandblasted resin composite rods representing a restoration were bonded to the IDS using the resin cement assigned for that group, then tested for shear bond strength and analyzed with two-way ANOVA. The two pieces resulting from the fracture were examined under SEM and their descriptions were reported. When the IDS monomer and resin cement monomer were both GPDM, shear bond strength increased compared to the GPDM baseline. No other combination of IDS monomer and resin cement monomer increased shear bond strength over the respective baseline, no matter whether the monomers were the same or different. The greatest bond strength was in the baseline (no IDS) group of Single Bond Universal Adhesive. The most common fracture mode was an adhesive failure at the IDS and resin cement junction. Cohesive failure frequently occurred in the SuperBond C&B resin cement when it was used as the resin cement. In conclusion, the type of acidic functional monomers in the IDS and resin cement affected the shear bond strength.
Arsenic Exposure and the Risk of Cancer
Authors: Pizarro Isabel
Published: September 2022

It is known that exposure to environmental chemicals increases the risk of cancerous and non-cancerous pathologies. Geomedical and anthropic evidence indicates that there is a close relationship between increased morbidities from cardiovascular diseases and cancer among the population in the Antofagasta Region and the etiology of exposure to arsenic. The most commonly used drugs with chemotherapy are platinum-based. The present work characterizes short-term urinary evacuation, that is, the pooled urine excreted 24 hours after the first cycle of treatments of cancer patients with cisplatin or carboplatin. The inorganic biochemical status and behavior of excreted As, Se and Pt administered to and evacuated by patients could be involved in the post-treatment quality of life of the patients and the evolution and final outcome of the disease. There were 90 patients in the group, 32 with lung cancer and 58 with different cancers termed “other types of cancer”, as well as 10 patients untreated with platinum-based drugs. Platinum and selenium were determined by ICP-OES and As by HGAAS. The detection limits were 7.7, 5.4 and 0.2 (ng/mL), respectively. The decreasing tendency of the administered Pt followed the order: carboplatin (other types of cancer) >cisplatin (lung cancer) >cisplatin (other types of cancer); the short-term urinary excretion of Pt was low. The decreasing tendency of the quantities of excreted Se was: carboplatin (other types of cancer) >cisplatin (other types of cancer) ≈ cisplatin (lung cancer); and the tendency of decreasing quantities of excreted As was cisplatin (other types of cancer) >carboplatin (other types of cancer) >cisplatin (lung cancer).The quantities of excreted Pt did not present significant differences among the cases of patients with lung cancer or with other cancers treated with cisplatin, despite significant variations in the quantities of Pt administered by the drug. The tendency in quantities of excreted Pt was similar to that of selenium and arsenic, but the evacuation of selenium was greater than that of arsenic, including in the group of patients with “other types of cancer” treated with drugs without Pt. The results of the study could arise from the subtle participation of antagonist mechanisms among Se, As and Pt that are involved in apoptotic and autophagic events in homeostasis, which could indicate the presence of cancer in patients from areas with chronic exposure to arsenic, as is the case of the Antofagasta Region in Chile.
Easiest and Accurate Confirmation of Early Pregnancy during Autopsy
Authors: Shrivastava Neelam
Published: September 2022

One of the causes for suicide in young and unmarried females is relationship without wed-log which turns into pregnancy. Due to failure of relationship or to hide the condition and guilt, they commit suicide. Sometimes during autopsy, misdiagnosis of pregnancy in absence of pregnancy causes embarrassing and controversial scenarios to families. However, on the other side, often pregnancy findings are not detected in early pregnancy which leads escape of accused from punishment. Therefore, an accurate test of pregnancy is essential. In prevailing practice, size of uterus and corpusluteum are increased during pregnancy, which leads to definitive diagnosis. Nonetheless in early pregnancy, size of uterus and corpusluteum doesn’t increase considerably and findings are usually untraced. The proposed method is easy and confirmatory test for the same. It is done by examining either urine or blood serum for hCG (Human Chorionic Gonadotropin) of deceased by a hCG strip. Test result shows positive if deceased aborted pregnancy within 15 days of death.
Carbon Nanomaterials as a Potential Agents for Induction of Apoptosis In Cancerous Tissue
Authors: Lahir YK
Published: September 2022

Cancerous condition is the result of abnormal physiological and cellular mechanisms that develop in an individual. The cells prone to cancer exhibit complexed behavioral abnormalities and disobedience to the normal cellular signaling pathways. Benign and malignant cancers show different proliferative behavior depending on the type of cells, their location, and functions. The cancerous tissues have increased vascular supply and a lower ratio of the rate of conversion of oxy-hemoglobin to deoxy-hemoglobin. In tissues, like the dense radiographic breast, show some morphological changes in the cell organelles like nuclei. The carbon nanoparticles act as suitable agents for carrying antiviral drugs, antibiotics, anticancer drugs, agents for imaging, and thermal ablation. Further, considering the multifaceted features, carbon nanomaterials can be a potential agent to induce apoptosis in the cancerous tissue that might help to restrict its growth. All these intentions need careful examinations, applications at laboratory, clinical, and mass-scale production, keeping in mind the environmental, judicial aspects, and human tendencies of maximizing their benefits. This short review is an effort to evaluate the potentials of carbon nanomaterials that can induce apoptosis in cancer tissue.
Is Genotoxicity of Peroxisome Proliferator-Activated Receptor Agonists Due to Oxidative Stress Via Agonistic Pathways?
Authors: Sasaki Yu F
Published: September 2022

In order to investigate the relationship between genotoxicity and peroxisome proliferator-activated receptor (PPAR) agonistic effects, we conducted two kinds of comet assays (cellular and acellular), a micronucleus (MN) test, and a TK mutation assay with and without PPAR antagonists using human lymphoblastoid cells. PPARα agonist clofibrate (CLF) and PPARγ agonists indomethacin (IND) and pioglitazone (PGZ) showed positive responses in the cellular comet assay, TK mutation assay, and detection of intracellular reactive oxygen species (ROS), but not in the acellular comet assay and MN test. PPARα antagonist (GW6471) suppressed the induction of ROS, DNA damage, and TK mutation by CLF. PPARγ antagonist (BADGE) suppressed the induction of ROS, DNA damage, and TK mutation by IND and PGZ. Therefore, CLF and two PPARγ agonists (PGZ and IND) show genotoxicity by oxidative stress via PPARα and PPARγ agonistic pathways, respectively. Considering that some unrepaired DNA lesions induced by them persist to form gene mutations but not chromosome aberrations, there is a possibility that their genotoxic potential is due to mutagenic but not clastogenic potential by the production of ROS via agonistic pathway
Interactive Correlation between Exosomes and Nanomaterials
Authors: Lahir YK
Published: September 2022

The extracellular vesicular entities, also called as plasma dusts, are present in all biological fluids, cell lines and cultures, are fascinating the researchers. Investigations related to their structure, formation, biological, physiological, and cellular status reveal that exosomes are biostable, and morphologically resemble nanomaterials, specifically, those from mesenchymal stem-cells. As the exosomes are multi-utility cellular products, their cellular yield and quantification seems to be tedious. Exosomes as nanostructures enhance the efficacies of extracellular vesicles or exosomes by fusing with lateral endosomes or multivesicular bodies, and later bud off from plasma membrane in a similar manner as during endocytosis. These cellular vesicles are the functional backbone of most of inter and intracellular transport mechanisms. It becomes imperative to understand their characterization, factors affecting their behavior within and outside the cell. Ubiquitously, nanomaterials are used in biological, medical, pharmaceutical, and biomolecular fields. The combined use of exosomes and nanomaterials may act as useful tools for clinical and diagnostic applications as they reflect the physiological and pathological status of a system. The molecular crowding is a physiological process and controls dissipation of molecular structures that facilitate the effective functions, and determination of cellular physiochemical status. Therefore, it essentiates to appraise the implications of exosomes along with nanomaterials in relation to cellular, biomolecular, physicochemical aspects of interactions and their applications in the biomedical fields. In this review, an effort is made to explore the mechanism of their biogenesis, exosomes functions in association with nanomaterials, molecular crowding, and their structure and functional relationship.
Mechatronics- A Concept toward the Precision Planter
Authors: Yadav Rajvir
Published: September 2022

Farm mechanization is the key to provide a number of economic and social advantages to farmers. The most important of the economic benefits is the enhanced yield that comes as a result of increased mechanisation. Combination of mechanical linkage or systems replacing by some electronic components it’s become mechanical + Electronics = Mechatronics. Linear actuator is best example of mechatronics in term of combination of electronic and mechanical. In linear actuator no need to any hydraulic link, distributor, oil tank, hydraulic pump. In some cases its give better then the hydraulic control actuating devices. If we use mechatronics technologies into agriculture sector there have helpful in controlling system and compactness in whole mechanism.
Percentage Change in Reaction Time Can Predict Respiratory Quotient during Light Weight Schoolbag Carriage
Authors: Sen Devashish
Published: September 2022

While structured physical activity improves cardio-pulmonary parameters and Reaction Time (RT), heavy weight schoolbag carriage is detrimental. Schoolbag carriage may have either consequence. The purpose of this study is to explore the consequences of heavy and light weighing schoolbags on cardio-pulmonary parameters and RT. Healthy male participants (10-15 years) carrying schoolbags- 0%, 4%, 8%, 12%, 16% load of bodyweight walked (20-minutes) for 5 times each. For each of the 30 participants, during walks, COSMED k4b2 measured heart rate (HR), respiratory quotient (R), total energy expenditure (EEtot) and number of steps taken. Ruler-drop-test marked RT before and after each walk. RT improved after walking with schoolbags weighing 0%, 4% of bodyweight. RT didn’t improve for 8%, 12% carriage, worsened for 16% load carriage. HR and EEtot showed proportionality (r=0.24, p<0.05), R correlated positively to percentage change in RT (r=0.24, p<0.05) and inversely to number of steps taken (r=-0.40, p<0.01). Percentage change in RT could significantly predict R (R=1.223+0.028(Percentage RT change)). Respiratory quotient can predict whether or not reaction time worsens for 20-minutes schoolbag carriage as per Receiver Operating Characteristic (ROC) curve (Area Under Curve (AUC)=0.668, 95% confidence interval: 0.558-0.779, p<0.01). Carrying light-weight schoolbags (4% of bodyweight) for 20-minutes is beneficial, but heavy-backpack carriage effectuates adverse cardio-pulmonary response and higher RT.
Distribution and Abundance of Dengue Vector(S) Mosquito and Their Breeding Preferences in Five Selected Administrative Wards of Dhaka North City Corporation, Bangladesh
Authors: Priyanka Mahbuba Akter
Published: September 2022

Dengue fever (DF) and Dengue haemorrhagic fever (DHF) is the most significant arising arboviral disease which is spread from dengue virus infection. Aedes aegypti and Aedes albopictus are the known vectors of dengue virus worldwide. A house based entomological survey was conducted to identify the distribution, abundance of dengue vector(s) mosquitoes and their preferable breeding sites in five selected wards at Dhaka North City Corporation, during July to December 2019. Stegomyia indices were calculated using the exact binomial test. Association between climatic factors and Aedes species abundance were also studied. The highest prevalence of Aedes mosquitoes were found in July. We did not found any Ae.albopictus during the study period. The overall house index (HI), container index, and Breteau index were found 20, 2 and 31 respectively, during the survey period. The present study did not find any significant association (p > 0.05) with meteorological factors (mean temperature, lag rainfall & relative humidity) and the density of Aedes mosquitoes. It is not possible to get an exact idea of the dengue outbreak through a short-term Aedes mosquito survey. So, this study suggests year-long mosquito surveillance program to acquire more conception of dengue transmission and how dengue vector(s) species abundance playing the role.
The Role of Women in Improving Family Economy Amid COVID-19 Pandemic
Authors: Lubis Rini Hayati , Napitupulu Rodame Monitorir , Izzah Nurul
Published: September 2022

Since June 2020, Padangsidimpuan city was designated as a yellow zone during the Covid-19 pandemic. It has an impact on the household economy. These conditions pushed women to contribute in improving the family economy. The aim of this research is to know the role of women in the family economy improvement in the middle of the Covid-19 pandemic. The research used qualitative descriptive method with a total sample of 108 women. The result showed that 73 percent of sample have decreased income and 47 percent family spending increased during the Covid-19 pandemic. These impulse women to work for initiatively helping the family economy as the main goal. A total of 80 percent of self-employed entrepreneurs were trading, with a productive age of 28-54 years dominated by high school education as the background. The amount of revenue reached Rp 50,000-150.00 per day with an average total of dependent inside a family is 4 people. This means that women in the household could still improve the family economy. Therefore, it is necessary using technology to promote business through e-marketing such as: social media, promotion banners (delivery order) via mobile phone or Whatsapp. In addition, e-Marketing education in women is important to be noticed by various parties.
DETERMINANTS OF CUSTOMER DEPOSITS IN THE BANKING SECTOR LISTED ON INDONESIA STOCK EXCHANGE
Authors: Winarto Jacinta , Susan Marcellia , Herlina
Published: September 2022

ABSTRACT
The customers deposits are a matter to be considered by the bank. With the tendency of this declining customer deposits raised the question, what factors have influenced the declining of the customer deposits. Looking at the previous research and facts in the field, it is assumed that the influencing factors are the  people income, the state debt securities, the interest rates and the company size. This study aims to examine and analyze the effect of people income, state debt securities, interest rates and company size on customers deposits. This research method is a quantitative method. Further, the datas are analyzed by using multiple linear regression model. The population in this study are all the banks listed at the Indonesian Stock Exchange during the period of 2013-2019. Samples are taken by using purposive sampling, obtained 33 companies. The result of this research  showed that people income, interest rates, state debt securities and company size have effect on customers deposits, so it is useful for banks to see the influence of each of the above factors that can affect changes in deposit funds in banks and to take policies based on the factors above.
 Keywords: people income, state debt securities, interest rate, company size, customers deposits
 
ABSTRAK
Simpanan nasabah merupakan hal yang harus diperhatikan oleh bank. Dengan kecenderungan menurunnya simpanan nasabah tersebut menimbulkan pertanyaan, faktor apa saja yang mempengaruhi penurunan simpanan nasabah tersebut. Melihat penelitian-penelitian sebelumnya dan fakta-fakta di lapangan, diduga bahwa faktor-faktor yang mempengaruhinya adalah pendapatan masyarakat, surat utang negara, tingkat suku bunga dan ukuran perusahaan. Penelitian ini bertujuan untuk menguji dan menganalisis pengaruh pendapatan masyarakat, surat utang negara, suku bunga dan ukuran perusahaan terhadap simpanan nasabah. Metode penelitian ini adalah metode kuantitatif. Selanjutnya data dianalisis dengan menggunakan model regresi linier berganda. Populasi dalam penelitian ini adalah seluruh bank yang terdaftar di Bursa Efek Indonesia selama periode 2013-2019. Sampel diambil dengan menggunakan purposive sampling, diperoleh 33 perusahaan. Hasil penelitian menunjukkan bahwa pendapatan masyarakat, suku bunga, surat utang negara dan ukuran perusahaan berpengaruh terhadap simpanan nasabah, sehingga berguna bagi bank untuk melihat pengaruh dari masing-masing faktor di atas yang dapat mempengaruhi perubahan dana simpanan pada bank, dan mengambil kebijakan berdasarkan faktor-faktor di atas.
Kata kunci:  pendapatan masyarakat; surat utang negara; tingkat bunga; ukuran perusahaan; simpanan pelanggan
Best Practice systemisch-agiles Change-Management. „Weil das morgen noch so ist, weil das immer schon so war“
Authors: Huiber Patrick , Korn Robert
Published: September 2022

Gesteigerte Unsicherheit, intransparente Kommunikation und zähe Prozesse. Für diese wesentlichen Herausforderungen im Projektmanagement bietet das systemisch-agile Change-Management praktikable Ansätze. In diesem Artikel werden vier besonders wirksame davon vorgestellt. In den Grundsätzen des agilen Projektmanagements sowie des systemischen Change-Managements finden wir einige Parallelen, wie z. B. die Strukturierung in Zyklen und einen empirischen Entwicklungsprozess. Nicht zuletzt deshalb werden komplexe Prozesse wie Change-Vorhaben immer öfter agil und systemisch konzipiert und umgesetzt. Für die aktuellen Herausforderungen im Projektmanagement in Form gesteigerter Unsicherheit, intransparenter Kommunikation und einer unübersichtlichen Tool-Landschaft bieten sich vier konkrete Maßnahmen an: 1. Zeit in die Auftragserklärung investieren. 2. Einen lebendigen Kick-off-Workshop gestalten. 3. Ein hybrides Kollaborationssystem entwickeln. 4. Eine selbstorganisierte Arbeitsstruktur in variablen Zyklen. In diesem Artikel werden diese vier Schlüsselfaktoren erläutert und mit schnell anwendbaren Tools ergänzt.
Martha Nussbaum's Feminist Philosophy on Body Autonomy and Its Relationship to the Experiences of Women Survivors of Child Marriage: A Case Study in Sukamara, Central Kalimantan.
Authors: Munte Alfonso , Korsina Riam Esobio
Published: September 2022

This paper traces the journey of women who survived child marriage in Sukamara, Central Kalimantan. Sukamara is the district in Central Kalimantan with the highest child marriage rate. Central Kalimantan is one of the provinces with the highest child marriage rate in Indonesia. The purpose of this research how to analize experiences of survivors of child marriage victims regarding bodily autonomy. Then, the writer connects the autonomy of the body with the moral problematic phenomenon of objectivity as a power relation according to Martha Nussbaum's understanding. Researchers used interview research methods. The research instrument uses a detailed list and then is classified into factual solids, categories and theme questions. The results of the study, the research subjects experienced bitter experiences which were illustrated by acts of sexual violence, neglect from husbands and in-laws, and the lack of reproductive health due to women's responsibilities from power relations in survivors of child marriage. In addition, this study also confirmed Martha Nussbaum's theory that objectification is present in the absence of approval, pride and independence which is something negative.
Konsep Perdamaian Agama Islam sebagai Ummat Khalayak dalam Surah Al-Hujurat Ayat 13
Authors: Dwi Cahyati Ernah , Ahmad Rizal Derry
Published: September 2022

This article seeks toexplain that humans know each other among religious people in the Qur'an Surah Al-Hujurat: 13 and as an interpretation shows the greatness of God that man was created to have a high sense of tolerance. In  this article, an important meaning is found, namely God's call for mankind in the world to know with each other regardless of anything, as well as the basic concept of Islam that provides peace and affection between fellow creatures of God. Through this paper, a little review of the principles of Islam as a religion of peace. Surah Al-Hujurat: 13 includes surah which supports the concept of rahmatan lil alamin.
co-construcción del Conocimiento
Authors: Peyloubet Paula , Fenoglio Valeria
Published: September 2022

La producción del Hábitat está signada por una multitud de variables y presiones que generan procesos de  exclusión social. Este artículo pone en discusión esta manera de producir Hábitat que, socialmente naturalizada, se lee como la única manera posible, generando la obligada maniobra posterior, de incluir a quienes el propio proceso deja fuera.La Resignificación Simbólica del Hábitat se entenderá, en este trabajo, como el trayecto de luchas frente a las hegemonías que producen Hábitat, incluyendo tres momentos categorizados teóricamente en cuestionamiento, transformación y nuevo orden. La Co-construcción se erige aquí como el nuevo orden emancipatorio, resultado de este trayecto de luchas. Para poner en evidencia estos mecanismos de exclusión-inclusión, se presentará en el final, una experiencia alternativa de producción de hábitat, bajo un enfoque de Co-construcción de Conocimiento en el marco de una Red Federal Productiva, constitui-da con el fin de institucionalizar otra forma de producción que no necesita de artilugios de inclusión posterior, porque es engendrada bajo una concepción colectiva y cooperativa de producción de hábitat, siendo sostenida por una red de saberes heterogéneos, que se nutre del acervo cultural y las estrategias de comunicación de los actores que dinamizan dicho proceso.
¿Rock and roll o rock and balls?
Authors: Segura Cecilia
Published: September 2022

En este artículo se intentará abordar la problemática que implica la posición hegemónica del varónheterocis -en tanto categoría social- como referente dentro del circuito musical del rock, desde los inicios de este movimiento cultural. ¿Podríamos hablar de un escenario invisible? ¿O más bien de un circuito que excluye identidades no hegemónicas en el ambiente musical? ¿Cómo se construyen los contornos que delimitan el espacio de aparición pública de las mujeres y personas de la comunidad LGTBIQ+? ¿Por qué a ciertas identidades les resulta más difícil consolidarse profesionalmente en los diferentes rubros del rock?
Graciela Paraskevaídis y el CLAEM
Authors: Sirvent María Lihuen
Published: September 2022

Graciela Paraskevaídis fue latinoamericana por un esfuerzo consciente basado en una postura ideológica consustancial con su práctica profesional. Su paso por el Centro de Altos Estudios Musicales (CLAEM), en el bienio 1965-1966, propició un punto de inflexión en su práctica musical al conectarla con colegas de diferentes países latinoamericanos. Para corroborar el impacto que el CLAEM pudo tener en la producción musical de la compositora, en este trabajo analizaremos 5 piezas para piano, una obra del año 1964 y la contrastaremos con su producción pianística posterior. Este análisis nos permitirá caracterizar rasgos que definen su música y empezar a comprender de qué modo éstos se hallaban incipientes en su producción temprana, así como también documentar posibles búsquedas artísticas que luego fueron descartadas.
La dialéctica diaria
Authors: Lucaioli Guido , Poeta Diego
Published: September 2022

El trabajo que presentamos aquí es una reseña del libro Improvisar. El arte, la vida del autor Stephen Nachmanovitch, especialista en improvisación e interacción de diversas disciplinas artísticas. La obra, dividida en tres grandes capítulos, fue publicada originalmente en inglés por la editorial New World Library de Canadá en 2019 y traducida al castellano por Terresa Arijón y editada por Paidós en el año 2021.
PROMOTING TECHNOLOGY-BASED LEARNING IN NIGERIA: ROLE OF THE STAKEHOLDERS
Authors: Laleye Ademiotan Moriyike
Published: September 2022

This study investigated the roles of stakeholders in promoting technology-based learning in Nigeria. The population of the study comprised all senior secondary school III students in public secondary schools, their teachers and parents in Akoko South West, Ondo State. Simple random procedure was used to select ten (10) schools out of seventeen (17) secondary schools in the Local Government. Four hundred (400) samples comprised 300 students, 50 teachers and 50 parents were randomly selected from the population. Self-developed questionnaire served data collection purpose. The validated instrument, has a reliability index of 0.68. Findings from the study revealed that parents are to provide ICT gadgets for their children at home and monitor them so as to guide against abuse of the technology; it was discovered that Government, P.T.A., old students, philanthropists are to build and equip ICT units in schools and to, organize workshops and seminars for teachers on ICT. It was concluded that building and equipping of ICT centers by the government is very germane, PTA old students association and philanthropists. However, teachers are to strategically and technically make use of technology to foster teaching and learning in Nigeria. It was recommended that workshop and seminars are to be organized for personnel in ICT in schools by the Government and teachers are to use new innovative method to blend learning and make the process technology-based.Key words: stakeholders, parents, old students, technology-based, learning.
La clave política en «las Meninas»
Authors: Muñoz Jiménez José Miguel
Published: September 2022

En el año velazqueño de 1990 resulta del todo provechoso escribir sobre Velázquez, siempre vigente y gran problema para todo español.