bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Boston Consulting Group (BCG) Pada Hotel Royal Senyiur Prigen Pasca Pandemi Covid-19
Authors: Novandini Dellia , Yuliati Yuliati
Published: June 2024

The COVID-19 pandemic greatly impacted business activities, especially in the hospitality industry. One hotel which got an impact was the Royal Senyiur Hotel Prigen. Even though passing the pandemic era, it needs an appropriate strategy to survive and get back to normal in this transition stage. The research aims to reveal the BCG matrix quadrant position and the strategy implemented in the post-pandemic COVID-19. The research employed a case study to describe and conduct an in-depth analysis of a certain case. The qualitative data consisted of general terms and information on finding out something. The research used primary data from interviews with informants and secondary data from documentation. Based on the research result, Royal Senyiur Hotel Prigen has a market growth of 41.5%. Meanwhile, its relatif target markets were 1.21 and 1.27 times in 2022 and 2023, respectively. From the two calculations related to its market, the BCG matrix quadrant position is in Quadrant II, that is, Star with the strategy of hold.
Peranan Entrepreneurial Orientation Dalam Meningkatkan Competitive Advantage Melalui Innovation Capability Sebagai Variabel Mediasi
Authors: Indriyani Ratih , Tantry Senak Joshua Geraldino
Published: June 2024

Perkembangan usaha di Indonesia menimbulkan persaingan bagi pemilik bisnis. Dalam mengatasi persaingan, UKM harus meningkatkan haru keunggulan kompetitif bisnis. Namun, masih banyak pengusaha yang terhambat dalam meraih keunggulan usahanya karena belum diimbangi dengan keinginan berinovasi dan mengembangkan orientasi berwirausaha mereka. Penelitian ini akan melakukan analisis pengaruh entrepreneurial orientation dalam meningkatkan keunggulan kometitif melalui kemampuan inovasi. Penelitian ini menggunakan penelitian eksplanatori dengan pendekatan kuantitatif. Teknik pengambilan sampel menggunakan purposive sampling dengan melibatkan 118 pemilik UKM di NTT Indonesia. Penelitian ini menunjukkan bahwa entrepreneurial orientation berpengaruh signifikan terhadap competitive advantage melalui innovation capability pada pelaku usaha.
 
Kata Kunci: entrepreneurial orientation, competitive advantage, innovation capability
Kontribusi PKB Dan BBNKB Bagi Pajak Daerah Provinsi Jawa Barat
Authors: Pandingan Michellevanessa , Hutapea Joan Yuliana
Published: June 2024

Local Taxes are one of the local government revenues that is beneficial for financing and developing a region. Each region has revenues that sometimes result in inequality in the development of an area, due to differences in the potential of each region. Local tax revenue is one of the largest contributors to Local Own-Source Revenue (PAD). This study aims to retest the contribution of Motor Vehicle Tax (PKB) and Tax of Transfer Vehicle Ownership (BBNKB) to local taxes revenue in West Java Province in 2015-2022. This study used quantitative methods with a causal associative analysis process. Statistical data processing uses descriptive analysis, correlation and determination efficiency, regression and significance tests from data on the realization of PKB, BBNKB and local taxes revenues. The results of observations based on statistical analysis show that local taxes are influenced by PKB (sig. 0.00 < 0.05) but not by BBNKB (sig. 0.06 > 0.05). Simultaneously, local taxes are affected by PKB and BBNKB (sig. 0.00 < 0.05).
PENGEMBANGAN PERANGKAT PEMBELAJARAN BERBASIS MODEL INQUIRY TRAINING TERHADAP PEMAHAMAN KONSEP SISWA PADA MATERI GETARAN HARMONIS
Authors: Amelia Isra , Azhar Azhar , Irianti Mitri
Published: June 2024

Penelitian ini bertujuan untuk mengembangan perangkat pembelajaran dengan menggunakan model Inquiry Training pada materi Getaran Harmonis. Perangkat pembelajaran yang dikembangkan adalah RPP, LKPD, dan Tes Pemahaman Konsep Metode penelitian yang digunakan adalah Research and development (R&D) untuk menghasilkan produk dan menguji keefektifan produk tersebut, dalam hal ini berupa perangkat pembelajaran Rancangan penelitian menggunakan model 4D yaitu Define, Design, Development dan Dissemination.. Teknik pengumpulan data di validasi oleh validator yang terdiri dari tiga orang yaitu, dua orang dosen pembimbing dan satu orang dosen pembahas. Berdasarkan hasil penelitian diperoleh rata-rata validitas-2 Rencana Pelaksanaan Pembelajaran (RPP), Lembar Kerja Peserta Didik (LKPD), dan tes pemahaman konsep yaitu 3,43 kategori sangat tinggi dengan kriteria validitas yaitu valid. Hasil validitas-2 RPP yaitu 3,42 kategori sangat tinggi dengan kriteria validitas yaitu valid, hasil validitas-2 LKPD yaitu 3,52 kategori sangat tinggi dengan kriteria validitas yaitu valid, dan hasil validitas-2 tes pemahaman konsep yaitu 3,36  kategori sangat tinggi dengan kriteria validitas yaitu valid. Berdasarkan hasil analisis data yang di dapat dari penelitian yang dilakukan maka dapat ditarik kesimpulan bahwa pengembangan perangkat pembelajaran    berorientasi model pembelajaran Inquiry Training pada materi getaran harmonis SMA dinyatakan valid oleh validator dengan hasil yang diperoleh pada validasi-2 berada pada kategori sangat tinggi dan dapat dijadikan bahan ajar pada proses pembelajaran di sekolah.
PENERAPAN SIMULASI PHET KONVERSI ENERGI BERBASIS SAINTIFIK UNTUK MENGUKUR HASIL BELAJAR MAHASISWA PENDIDIKAN FISIKA
Authors: Amin Ahmad , Yuneti Armi
Published: June 2024

Pemahaman konsep Fisika di Program Studi pendidikan Fisika Universitas PGRI Silampari sangat penting untuk mendukung bidang keahlian mereka dalam memahami materi yang lebih kompleks. Mata kuliah Mekanika terdiri dari berbagai macam konsep yang abstrak diantaranya pada materi Konversi Energi. Penggunaan program komputer seperti aplikasi PhET Simulasi sangat penting guna menjelaskan materi yang abstrak tersebut. Tujuan penelitian ini adalah untuk melihat minat belajar mahasiswa setelah diterapkan media PhET berbasis Saintifik dalam pembelajaran. Metode yang digunakan yaitu metode deskriptif, dan analisis data menggunakan analisis deskriptif  mengenai  minat belajar setelah penerapan pembelajaran. Subjek uji coba dalam penelitian ini yaitu mahasiswa semester III  yang mengambil mata kuliah Mekanika  di Program Studi pendidikan Fisika Universitas PGRI Silampari. Instrumen penelitian yaitu Soal Tes yang berjumlah 10 soal pilihan ganda. Hasil penelitian diperoleh mahasiswa setelah penerapan media PhET simulasi mencapai nilai rata-rata 85, dengan nilai persentase 95%, sehingga dapat dikatakan bahwa penerapan media PhET simulasi berbasis Saintifik pada materi konversi energi dapat membuat hasil belajar mahasiswa dianggap berhasil. Sehingga disimpulkan bahwa setelah pembelajaran menggunakan media PhET, hasil belajar mahasiswa dianggap berhasil.
Physical Violence During Pregnancy and Associated Factors of Mental Distress Among Women in Yangon Region, Myanmar: A Secondary Analysis of a Cross-Sectional Study
Authors: Aye Win Thuzar , Hein Zaw Myo , Botta Matteo , Bjertness Espen , Liabsuetrakul Tippawan
Published: June 2024

Objective: Violence against women during pregnancy is a critical human rights issue and a significant global public health concern. The study aimed to assess the prevalence of physical violence during any pregnancies and mental distress by ever-pregnant women, investigate the association between physical violence and mental distress, and explore additional factors linked to mental distress.Material and Methods: This secondary analysis of household-based cross-sectional study included 1,045 ever-pregnant women aged 18-49 years from Yangon Region, Myanmar, interviewed between October and November 2016. Physical violence and mental distress were assessed utilizing the standardized Demography and Health Survey questionnaire and the Hopkins Symptom Checklist-10, respectively. Multiple logistic regression analysis was used for association between physical violence and mental distress.Results: We found that 6.4% (95% CI 5.1% to 8.1%) of the women had experienced physical violence during pregnancy and 34.1% (95% CI 31.3% to 37.0%) had suffered mental distress. We identified no significant association between physical violence during pregnancy and mental distress. Women residing in an urban area, having more than three children, experiencing family debt, having poor health status, having a partner with controlling behavior, and having a partner who consumed alcohol were significantly associated with mental distress.Conclusion: One in 16 women in Yangon, Myanmar, had experienced physical violence during a pregnancy, while approximately one-third of the women had suffered from mental distress. It is a problem of serious concern in many countries to screen pregnant women for risk factors associated with mental distress during their antenatal care and prepare the appropriate mental health services for them.
حوار دارفور: من الحرب إلى السلام والتعايش والاستقرار
Authors: سعيد سامي
Published: June 2024

نظمت المؤسسة الدولية للديمقراطية والانتخابات حواراً ديمقراطياً وشفافاً لأكاديميين وخبراء وناشطي مجتمع مدني وجماعات شبابية من دارفور يعيشون في الشتات، وذلك في كمبالا بأوغندا، في ٢٨ - ٣٠ أغسطس ٢٠٢٣، بعنوان: ‘من أهوال الحرب إلى نعيم السلام والتعايش والاستقرار’. وهدف المؤتمر إلى التقاء أهالي دارفور في الشتات، بغض النظر عن خلفياتهم السياسية والعرقية، لمناقشة التحديات والحلول المحتملة. حيث أتاح لهم التفاعل فيما بينهم والاستفادة من المعارف والخبرات والتجارب والمهارات التي قدمها المشاركون في الحوار. وعلى الرغم من الاضطرابات السياسية والعرقية في الإقليم، أظهر المشاركون درجة عالية من الموضوعية وقبول الآخر والانفتاح على الآراء الجديدة. وقدم فريق من الخبراء المميزين دراسات تناولت مسائل بناء السلام في دارفور بطريقة مهنية وعلمية. لخص المؤتمر نتائج عمله على شكل توصيات إلى جميع الأطراف، لتكون بمثابة دليل لواضعي السياسات. وحضر الجلسة الختامية للمؤتمر ممثلون عن منظمات دولية كالأمم المتحدة والاتحاد الأوروبي. وقد صدر هذا التقرير في إطار المقترحات التي شدد عليها المشاركون في حوار دارفور.
Evaluating the synergistic effects of integrated nutrient management and foliar application of zinc sulphate (ZnSO4) on growth and growth attributes of rice (Oryza sativa L.)
Authors: DHILIPAN K. S. , BARADHAN G. , KUMAR S. M. SURESH , SATHIYANARAYANAN G. , RAMESH S.
Published: June 2024

In India, rice (Oryza sativa L.) is a major cereal crop that accounts for 44.40 million hectares i.e. 30 per cent of the nation's total cultivated land. Nutrient management is one of the most important production restrictions for achieving a sustainable yield from a particular farming method. Ineffective nutrient management is a major problem in rice cultivation. Due to overuse of fertilizer there is loss of soil productivity and reduction in soil fertility. So, this research was conducted with a view of careful and effective use of chemical fertilizers, farm yard manure, vermicompost, press mud and poultry manure along with the foliar application of zinc sulphate, an integrated nutrient management system plays a critical role in balancing the soil fertility and plant nutrient supply to an optimal level. This approach results in an environmentally friendly and financially feasible solution for this issue and not only helps in supplementing requirements but also improves soil's physical, chemical, and biological properties. A field experiment was conducted in the Department of Agronomy, Faculty of Agriculture, Annamalai University, Tamil Nadu during June-September 2023 to assess the synergistic effects of integrated nutrient management along with foliar zinc sulphate on the growth of rice. The study evaluated nine treatments in a randomized block design. These treatments included varying levels of nitrogen supplemented with different sources of organic manures viz., farm yard manure, vermicompost, press mud and poultry manure and foliar application of zinc sulphate (ZnSO4). The results revealed that combining 75% nitrogen through urea and 25% nitrogen from vermicompost and 100% P and K along with foliar application of zinc sulphate (0.5%) at 25 and 50 days after transplanting (DAT) significantly improved all growth parameters viz., plant height, leaf area index, dry matter production, root length and root volume, number of tillers m-2, crop growth rate, and absolute growth rate of rice.
Fault Tectonites of the Yenisei Shear Zone (Yenisei Ridge): Evidence and Thermomechanical Numerical Model of Generation of Tectonic Overpressure
Authors: Polyansky O. P. , Likhanov I. I. , Babichev A. V. , Kozlov P. S. , Zinoviev S. V. , Sverdlova V. G.
Published: June 2024

Based on the proposed numerical model of the stress-strain state of polymineral rocks, which describes the formation of blastomylonites in the Yenisei Regional Shear Zone (PRSZ) in the Yenisei Ridge, the possibility of local tectonic overpressure exceeding the lithostatic pressure in rocks subjected to shear deformations is shown. For tectonites of the southern (Angara-Kan block) and northern (Isakovka terrane and Garevka complex) segments of the PRSZ, estimates of the maximum overpressure were obtained from 2–3 to 4–5 kbar, which range from 25 to 50% of the lithostatic pressure. It is shown that excess pressures can be preserved in a local volume on a geological time scale sufficient for their fixation in metamorphic minerals. Model values of overlithostatic pressure in garnet-amphibole tectonites and geobarometric estimates of peak values during stress metamorphism allow us to offer new evidence of pressure inhomogeneity in natural mineral associations. Using the results of numerical modeling for the evolution of fault metabasite blastomylonites, it was established that the overpressure at the stage of syn-deformation metamorphism in the shear zone are possible at temperatures up to 600–650°C and not reaching 800°C; the presence of fluid or partial melt prevents the occurrence of overpressure. The amount of excess pressure due to shear stresses depends on the mineral composition and structure of the rock.
Geochemical Thermometry of Ore-Bearing Gabbronorites from the Apophisis of the Yoko-Dovyren Massif: Composition, Amount of Olivine, and Conditions of Sulphide Saturation in the Parental Magma
Authors: Pshenitsyn I. V. , Ariskin A. A. , Sobolev S. N.
Published: June 2024

The temperature and compositional parameters of the parental magma of the ore-bearing apophysis DV10 from the Yoko-Dovyren massif are estimated based on the results of thermodynamic modeling the equilibrium crystallization of melts of 24 samples, following the method of geochemical thermometry. Thermometric calculations were carried out using the COMAGMAT-5.3 program with a step of 0.5 mol. % to a maximum degree of crystallization 75–85% under oxygen fugacity controlled by the QFM buffer. The model order of mineral crystallization corresponds to the sequence: olivine (Ol) + + Cr-Al spinel (Spl) → plagioclase (Pl) → high-Ca pyroxene (Cpx) → orthopyroxene (Opx). Silicate-sulfide immiscibility was modeled to occur mostlybefore the onset of plagioclase crystallization, being consistent with sulfide saturation of the parental magma. The results of calculations demonstrate the convergence and intersection of the model liquid lines of descent at temperatures of about 1185°C. When applied to the average composition of the DV10 apophysis, this temperature indicates the existence of a suspension of the original crystals (52.1 wt. % cumulus olivine (Fo83.6), 2.3 wt. % plagioclase (An79.7), 0.24% clinopyroxene (Mg# 88.8), 1 wt. % aluminochromite (Cr# 0.62)) and about 0.2% sulfide liquid in a moderately magnesian melt (53.6 wt. % SiO2, 7.4 wt. % MgO). At that the solubility of sulfide sulfur (SCSS) was estimated to be 0.083 wt. %. This heterogeneous system had a viscosity of 4.71 log. units (Pa · s) and an integral density of 2929 kg/m3. Such rheological properties do not contradict the possibility of the migration and emplacement of the protocumulus mush from the main Dovyren chamber. However, a more probable scenario includes a localized accumulation of olivine in the trough-like part of the DV10 subchamber, which preceded or occurred in parallel to the accumulation of segregated sulfides.
Orientierung an Empowerment und Powersharing als Konkretisierungsmöglichkeit intersektionaler Perspektiven in der (Offenen) Kinder- und Jugendarbeit
Authors: Menhard Ioanna
Published: June 2024

Analyse und Reflexion von Herrschaftsverhältnissen in Sozialer Arbeit sind zunehmend mit dem Ansatz der Intersektionalität verbunden. Im Beitrag wird untersucht, inwiefern intersektionale Perspektiven mit Blick auf Handlungsmöglichkeiten konkretisiert werden können. Dabei sind Empowerment und Powersharing im Feld der (Offenen) Kinder- und Jugendarbeit ausschlaggebend. Anhand von Expert*inneninterviews mit Fachkräften sowie einer theoretischen Untersuchung werden Rahmenbedingungen und Praxen systematisiert. So lassen sich Safer Spaces und eine Kombination aus Empowerment und Powersharing als Möglichkeit verstehen, Intersektionalität zu übersetzen. Gleichzeitig werden Widersprüche einer intersektionalen Veränderungsperspektive im Zusammenhang mit der kapitalistisch-nationalstaatlichen Rahmung sowie Normalisierungsfunktion Sozialer Arbeit deutlich.
„Abgebrochenes Sterilett“ – eine objektzentrierte Geschichte von Schwangerschaftsverhütung und weiblichen Praktiken zur reproduktiven Selbstbestimmung in den 1930er-Jahren in Deutschland
Authors: Nolte Karen
Published: June 2024

Ausgehend von einem Kasten mit Intrauterinpessaren in der Sammlung der Universitätsfrauenklinik in Würzburg aus den 1930er-Jahren geht der Beitrag erstens der Frage nach, wie diese Pessare zu Sammlungsobjekten wurden, um im zweiten Schritt von den Objekten ausgehend anhand von Krankenblättern die Geschichte ihrer ehemaligen Besitzerinnen zu rekonstruieren. Gemäß der Methode der Objektbiografie werden die Objekte wissenschaftlich erschlossen, ergänzt durch eine praxeologische Herangehensweise und Perspektiven der Science und Technology Studies. Über die Objekte lässt sich das Körperwissen von Frauen zum routinisierten Umgang mit medizinischen Objekten der Empfängnisverhütung rekonstruieren. Die Biografien dieser Objekte zeigen, dass die Nutzerinnen die Intrauterinpessare nicht mehr als Fremdkörper wahrnahmen und erst in dem Moment an das Objekt in ihrem Körper erinnert wurden, in dem es Beschwerden verursachte, während Ärzt*innen diese Objekte als schädliche Fremdkörper problematisierten.
Combining decomposition and graph capsule network for multi-objective vehicle routing optimization
Authors: Zhang Haifei , Ge Hongwei , Li Ting , Zhou Lujie , Su Shuzhi , Tong Yubing
Published: June 2024

In order to alleviate urban congestion, improve vehicle mobility, and improve logistics delivery efficiency, this paper establishes a practical multi-objective and multi constraint logistics delivery mathematical model based on graphs, and proposes a solution algorithm framework that combines decomposition strategy and deep reinforcement learning (DRL). Firstly, taking into account the actual multiple constraints such as customer distribution, vehicle load constraints, and time windows in urban logistics distribution regions, a multi constraint and multi-objective urban logistics distribution mathematical model was established with the goal of minimizing the total length, cost, and maximum makespan of urban logistics distribution paths. Secondly, based on the decomposition strategy, a DRL framework for optimizing urban logistics delivery paths based on Graph Capsule Network (G-Caps Net) was designed. This framework takes the node information of VRP as input in the form of a 2D graph, modifies the graph attention capsule network by considering multi-layer features, edge information, and residual connections between layers in the graph structure, and replaces probability calculation with the module length of the capsule vector as output. Then, the baseline REINFORCE algorithm with rollout is used for network training, and a 2-opt local search strategy and sampling search strategy are used to improve the quality of the solution. Finally, the performance of the proposed method was evaluated on standard examples of problems of different scales. The experimental results showed that the constructed model and solution framework can improve logistics delivery efficiency. This method achieved the best comprehensive performance, surpassing the most advanced distress methods, and has great potential in practical engineering.
Semi-supervised contrastive learning with decomposition-based data augmentation for time series classification
Authors: Kim Dokyun , Cho Sukhyun , Chae Heewoong , Park Jonghun , Huh Jaeseok
Published: June 2024

While time series data are prevalent across diverse sectors, data labeling process still remains resource-intensive. This results in a scarcity of labeled data for deep learning, emphasizing the importance of semi-supervised learning techniques. Applying semi-supervised learning to time series data presents unique challenges due to its inherent temporal complexities. Efficient contrastive learning for time series requires specialized methods, particularly in the development of tailored data augmentation techniques. In this paper, we propose a single-step, semi-supervised contrastive learning framework named nearest neighbor contrastive learning for time series (NNCLR-TS). Specifically, the proposed framework incorporates a support set to store representations including their label information, enabling a pseudo-labeling of the unlabeled data based on nearby samples in the latent space. Moreover, our framework presents a novel data augmentation method, which selectively augments only the trend component of the data, effectively preserving their inherent periodic properties and facilitating effective training. For training, we introduce a novel contrastive loss that utilizes the nearest neighbors of augmented data for positive and negative representations. By employing our framework, we unlock the ability to attain high-quality embeddings and achieve remarkable performance in downstream classification tasks, tailored explicitly for time series. Experimental results demonstrate that our method outperforms the state-of-the-art approaches across various benchmarks, validating the effectiveness of our proposed method.
Research on the use of communication big data and AI artificial intelligence technology to construct telecom fraud prevention behavior portrait
Authors: Chen Dong , Wu Yang
Published: June 2024

A solid foundation for behavior portrait construction in the fight against telecom fraud is the goal of this research. The study explores the integration of communication AI and Big Data technologies, focusing on the perspective of artificial intelligence. By using insights obtained from a telecom fraud detection model that relies on users’ behavior variations expressed through time-varying signatures, the goal of this study is to enhance fraud prevention strategies in the telecom industry. Through the examination of call detail records and customer profile information, the TeleGuard AI Fraud Prevention Framework (TGAI-FPF) aims to recognize suspicious trends and variations that are potentially suggestive of fraudulent actions. The purpose of the model is to generate behavior portraits that are capable of capturing the distinctive aspects of fraudulent conduct in telecom networks. This will be accomplished through the utilization of advanced analytics and machine learning algorithms. The study highlights the significance of leveraging big data analytics and artificial intelligence technologies to efficiently detect and thwart fraudulent activity in the telecom industry. The results of this study should fortify the defenses of telecom networks against growing fraudulent schemes and help in the development of preventative measures to combat fraud. This is the anticipated manner in which the results will add.
The Clinical Aspects of COVID and Alzheimer’s Disease: A Round-Up of Where Things Stand and Are Headed
Authors: Tavares-Júnior José Wagner Leonel , Ciurleo Gabriella Cunha Vieira , Feitosa Esther de Alencar Araripe Falcão , Oriá Reinaldo B. , Braga-Neto Pedro
Published: June 2024

The link between long COVID-19 and brain/cognitive impairments is concerning and may foster a worrisome worldwide emergence of novel cases of neurodegenerative diseases with aging. This review aims to update the knowledge, crosstalk, and possible intersections between the Post-COVID Syndrome (PCS) and Alzheimer’s disease (AD). References included in this review were obtained from PubMed searches conducted between October 2023 and November 2023. PCS is a very heterogenous and poorly understood disease with recent evidence of a possible association with chronic diseases such as AD. However, more scientific data is required to establish the link between PCS and AD.
The Etiology of Rapidly Progressive Dementia: A 3-Year Retrospective Study in a Tertiary Hospital in China
Authors: Shi Qin , Liu Wei-Shi , Liu Fang , Zeng Yi-Xuan , Chen Shu-Fen , Chen Ke-Liang , Yu Jin-Tai , Huang Yu-Yuan
Published: June 2024

Background: Rapidly progressive dementia (RPD), characterized by a rapid cognitive decline leading to dementia, comprises a diverse range of disorders. Despite advancements in diagnosis and treatment, research on RPD primarily focuses on Western populations. Objective: This study aims to explore the etiology and demographics of RPD in Chinese patients. Methods: We retrospectively analyzed 323 RPD inpatients at Huashan Hospital from May 2019 to March 2023. Data on sociodemographic factors, epidemiology, clinical presentation, and etiology were collected and analyzed. Results: The median onset age of RPD patients was 60.7 years. Two-thirds received a diagnosis within 6 months of symptom onset. Memory impairment was the most common initial symptom, followed by behavioral changes. Neurodegenerative diseases accounted for 47.4% of cases, with central nervous system inflammatory diseases at 30.96%. Autoimmune encephalitis was the leading cause (16.7%), followed by Alzheimer’s disease (16.1%), neurosyphilis (11.8%), and Creutzfeldt-Jakob disease (9.0%). Alzheimer’s disease, Creutzfeldt-Jakob disease, and frontotemporal dementia were the primary neurodegenerative causes, while autoimmune encephalitis, neurosyphilis, and vascular cognitive impairment were the main non-neurodegenerative causes. Conclusions: The etiology of RPD in Chinese patients is complex, with neurodegenerative and non-neurodegenerative diseases equally prevalent. Recognizing treatable conditions like autoimmune encephalitis and neurosyphilis requires careful consideration and differentiation.
Aqueous and Plasma Levels of Phosphorylated Tau 181 in Individuals with Normal Cognition
Authors: Patel Hemal , Wisely C. Ellis , Robbins Cason B. , Parker Daniel , Challa Pratap , Grewal Dilraj S. , Fekrat Sharon
Published: June 2024

Background: Plasma and cerebrospinal fluid (CSF) levels of p-tau181 have been associated with Alzheimer’s disease (AD). The retina and vitreous have shown measurable quantities of phosphorylated tau 181 (p-tau181). The aqueous humor, which can be collected during cataract surgery, may have measurable concentrations of p-tau181. Objective: To determine whether p-tau181 is detectable in the aqueous humor and if so, whether it is associated with other measures that might be consistent with AD such as higher plasma p-tau181 concentration and lower Montreal Cognitive Assessment (MoCA-BLIND version 7.1) score. Methods: Aqueous humor samples, blood samples, and MoCA-BLIND scores were collected from patients who did not carry a clinical diagnosis of cognitive impairment at the time of cataract surgery. Aqueous p-tau181 concentrations and plasma p-tau181 concentrations were then measured using ultra-sensitive single-molecule assay ELISA technology. A rank-transformed mixed-effects multivariate regression model was used to determine associations between aqueous concentrations, plasma concentrations, and MoCA-BLIND scores. Results: 16 eyes of 16 participants were enrolled with an average age of 71.6. Average MoCA-BLIND score was 20.6/22, average aqueous p-tau181 concentration was 6.4 pg/mL, and average plasma p-tau181 concentration was 3.1 pg/mL. Higher plasma p-tau181 was significantly associated with higher aqueous p-tau181 (p = 0.02). Aqueous p-tau181 and plasma p-tau181 were negatively associated with MoCA-BLIND scores (p = 0.005 and p = 0.001 respectively) in these patients. Conclusions: Aqueous p-tau181 is positively correlated with plasma p-tau181 and is negatively correlated with MoCA-BLIND scores. Further study in individuals with mild cognitive impairment or AD characterized by cerebrospinal fluid and volumetric MRI metrics may yield further insights.
Toward efficient very low frequency wireless power transfer for EVs: From grid to battery
Authors: Bonnard Charles-Henri , Jamshidpour Ehsan , Fontchastagner Julien , Didier Gaëtan , Zandi Hamidreza , Takorabet Noureddine
Published: June 2024

This paper aims to improve the efficiency, affordability, and safety of Wireless Power Transfer (WPT) devices. While wireless inductive charging is common in devices like smartphones, charging electric vehicles presents significant challenges due to high frequency electromagnetic fields that can be dangerous for users and those nearby. Current systems are expensive due to the use of specialized materials and components. By developing WPT systems with drastically reduced frequency levels, this research has the potential to significantly impact the widespread adoption of affordable, safe, and efficient WPT devices for high-power applications like electric vehicle charging. In fact, using lower frequencies allows us to build WPT systems with far less expensive materials, e.g. no need of Litz wires and ferrites that can be replaced by single core copper wires and classical magnetic steels. The effectiveness of the method is demonstrated through simulation using MATLAB Simulink® and experimental tests. The results indicate that it is possible to maintain good performance, reduce limitations and costs, and improve user acceptance of WPT systems by considerably lowering the frequency of electromagnetic fields that are classically used in such systems.
Bayesian analysis for social science research
Authors: Luque Carolina , Sosa Juan
Published: June 2024

In this manuscript, we discuss the substantial importance of Bayesian reasoning in Social Science research. Particularly, we focus on foundational elements to fit models under the Bayesian paradigm. We aim to offer a frame of reference for a broad audience, not necessarily with specialized knowledge in Bayesian statistics, yet having interest in incorporating this kind of methods in studying social phenomena. We illustrate Bayesian methods through case studies regarding political surveys, population dynamics, and standardized educational testing. Specifically, we provide technical details on specific topics such as conjugate and non-conjugate modeling, hierarchical modeling, Bayesian computation, goodness of fit, and model testing.
Limitations of the propensity scores approach: A simulation study
Authors: Mandel Igor
Published: June 2024

Propensity scores (PS) have been studied for many years, mostly in the aspect of confounder matching in the control and treatment groups. This work is devoted to the problem of estimation of the causal impact of the treatment versus control data in observational studies, and it is based on the simulation of thousands of scenarios and the measurement of the causal outcome. The generated treatment effect was added in simulation to the outcome, then it was retrieved using the PS and regression estimations, and the results were compared with the original known in the simulation treatment values. It is shown that only rarely the propensity score can successfully solve the causality problem, and the regressions often outperform the PS estimations. The results support the old philosophical critique of the counterfactual theory of causation from a statistical point of view.
Development of out-of-sample forecast formulae for the FIGARCH model
Authors: Rakshit Debopam , Paul Ranjit Kumar
Published: June 2024

Volatility is a matter of concern for time series modeling. It provides valuable insights into the fluctuation and stability of concerning variables over time. Volatility patterns in historical data can provide valuable information for predicting future behaviour. Nonlinear time series models such as the autoregressive conditional heteroscedastic (ARCH) and the generalized version of the ARCH model, i.e. generalized ARCH (GARCH) models are popularly used for capturing the volatility of a time series. The realization of any time series may have significant statistical dependencies on its distant counterpart. This phenomenon is known as the long memory process. Long memory structure can also be present in volatility. Fractionally integrated volatility models such as the fractionally integrated GARCH (FIGARCH) model can be used to capture the long memory in volatility. In this paper, we derived the out-of-sample forecast formulae along with the forecast error variances for the AR (1) -FIGARCH (1, d, 1) model by recursive use of conditional expectations and conditional variances. For empirical illustration, the modal spot prices of onion for Delhi, Lasalgaon and Bengaluru markets, India and S&P 500 index (close) data are used.
Research progress in pulmonary rehabilitation in patients who have been weaned off mechanical ventilation: A review article
Authors: Xu Bi-Qing , Si Qin , Feng Yin-Ping , Guo Jing , Jiang Li-Ping
Published: June 2024

BACKGROUND: Patients who have been treated with mechanical ventilation for more than 72 hours are susceptible to symptoms such as hypoxia and respiratory muscle fatigue after weaning, which may result in weaning difficulty and delay, as well as an increased incidence of negative emotions such as anxiety and depression. Correct pulmonary rehabilitation exercise technique and timing can improve the weaning success rate, reduce the disability rate, and reduce the incidence of pulmonary infection, as well as reduce medical expenses. OBJECTIVE: This article provides a review of pulmonary rehabilitation interventions for mechanically ventilated patients, searching relevant literature through databases such as CNKI and PubMed, aiming to provide guidance for the successful weaning of mechanically ventilated patients. METHODS: We selected articles related to pulmonary rehabilitation interventions for mechanically ventilated patients from CNKI (China National Knowledge Infrastructure) and PubMed over the years. RESULTS: This article provides a comprehensive review of the research on lung rehabilitation for patients who are mechanically ventilated during the weaning process in an effort to serve as a guide for a successful transition from mechanical ventilation. CONCLUSION: Early pulmonary rehabilitation training can effectively increase the pulmonary function level and ventilation function of patients and reduce the duration of mechanical ventilation and hospitalization, and is an effective, safe, and feasible treatment method.
Study on serum miR-182 as a marker for diagnosis and prognosis of cervical cancer
Authors: Gao Fei , Wang Yongcun , Li Hao , Yin Jilai
Published: June 2024

BACKGROUND: Cervical cancer (CC) is a common female malignancy, with a global incidence rate second only to breast cancer. OBJECTIVE: To propose a new idea for early treatment and auxiliary diagnosis of CC by exploring the diagnostic and prognostic implications of serum miR-182 in CC. METHODS: We enrolled 70 CC patients, 35 cervical intraepithelial neoplasia (CIN) patients and 35 healthy controls (HCs), who visited The First Affiliated Hospital of Hainan Medical College Hospital between January 2015 and April 2016. miR-182 expression was quantified by real-time quantitative PCR and compared among the three groups. The correlation of serum miR-182 expression with patients’ clinical features was evaluated. The receiver operating characteristic curve (ROC) and the Kaplan-Meier method were used to evaluate the early diagnostic value and prognostic value of serum miR-182. Cox regression analysis was performed to determine serum miR-182 expression and its important role in predicting CC patients’ prognosis. RESULTS: Serum miR-182 expression was determined to be 0.345 ± 0.094, 0.369 ± 0.076, and 0.586 ± 0.157 in CC patients, CIN patients, and HCs, respectively (P< 0.001). Serum miR-182 expression had an obvious association with lymph node metastasis and pathological differentiation (P< 0.05). The area under the ROC curve (AUC) of serum miR-182 was 0.709 (95% CI: 0.622–0.795), the critical value was 0.456, the sensitivity was 81.4%, and the specificity was 52.9%. CC patients were grouped as either the low- (miR-182 < 0.3) or high-level group (miR-182 ⩾ 0.03) based on serum miR-182 levels, and a Cox regression model of OS was established. Serum miR-182 expression was identified as a factor independently influencing CC patients’ OS (P= 0.028); the death risk of the high-level group was 3.246 times that of the low-level group. CONCLUSION: Serum miR-182 expression is not only a biomarker for early diagnosis of CC, but also one of the independent factors influencing the survival and prognosis of CC patients.
Impact of lipoprotein(a) and fibrinogen on prognosis in patients with coronary artery disease: A retrospective cohort study
Authors: Liang Dakai , Liang Dandan , Liu Jin , Zheng Yiying , Huang Dehua , Li Zeliang , Huang Xiaoyu , Chen Jiyan
Published: June 2024

BACKGROUND: Despite the considerable progress made in preventative methods, medication, and interventional therapies, it remains evident that cardiovascular events (CVEs) continue to be the primary cause of both death and morbidity among individuals diagnosed with coronary artery disease (CAD). OBJECTIVE: To compare the connection between lipoprotein a (Lp[a]), fibrinogen (Fib), and both parameters combined with all-cause mortality to detect their value as prognostic biomarkers. METHODS: This is a retrospective study. Patients diagnosed with CAD between January 2007 and December 2020 at the Guangdong Provincial People’s Hospital (China) were involved in the study. 43,367 patients met the eligibility criteria. The Lp(a) and Fib levels were distributed into three tertile groups (low, medium, and high). All of the patients included in the study were followed up for all-cause mortality. Kaplan–Meier and Cox regression were performed to determine the relationship between Lp(a), Fib, and all-cause mortality. A concordance statistics model was developed to detect the impact of Fib and Lp(a) in terms of anticipating poor outcomes in patients with CAD. RESULTS: Throughout a median follow-up of 67.0 months, 6,883 (15.9%) patients died. Participants with high Lp(a) (above 27.60 mg/dL) levels had a significantly higher risk for all-cause mortality than individuals with low Lp(a) levels (below 11.13 mg/dL; adjusted hazard ratio [aHR] 1.219, 95% confidence interval [CI]: 1.141–1.304, p< 0.001). Similarly, patients with high Fib levels (above 4.32 g/L) had a significantly greater risk of developing all-cause mortality compared with those with reduced Fib levels (below 3.41 g/L; aHR 1.415, 95% CI: 1.323–1.514, p< 0.001). Patients with raised Lp(a) and Fib levels had the maximum risk for all-cause mortality (aHR 1.702; 95% CI: 1.558–1.859, p< 0.001). When considered together, Lp(a) and Fib caused a significant elevation of the concordance statistic by 0.009 (p< 0.05), suggesting a higher value for predicting mortality when combining the two indicators. CONCLUSION: High Lp(a) and Fib levels could be used as predictive biomarkers for all-cause mortality in individuals with CAD. The prediction accuracy for all-cause mortality improved after combining the two parameters.
Causal relationship between serum metabolites and interstitial lung disease in humans: A mendelian randomization study
Authors: Zhao Tingting , Lv Tian
Published: June 2024

BACKGROUND: A significant proportion of interstitial lung disease (ILD) patients experience two or more comorbidities, leading to an increasing burden of disease, frequent hospitalizations, and premature death. OBJECTIVE: To investigate the causal relationship between serum metabolites and ILD in humans using Mendelian randomization. METHODS: Genetic loci closely related to human serum metabolites were selected as instrumental variables (IVs), with the inverse-variance weighted method (IVW) as the primary method and the weighted median method (WME) and MR-Egger regression as auxiliary methods for Mendelian randomization analysis of the data. Meanwhile, the causal relationship between human serum metabolites and ILD was evaluated by OR, along with the assessment of the stability and reliability of the results via 3 methods, i.e., heterogeneity testing, gene pleiotropy testing, and sensitivity analysis. RESULTS: 8,234 single nucleotide polymorphism (SNP) loci were included as IV, among which 23 SNP loci were selected as IV. Specifically, IVW estimated that the risk of ILD in the anti-Jo-1 antibody-positive population was 4.122 times higher than that in the negative population (95% CI: 2.311–5.954, P< 0.001). IVW also supported a causal effect between anti-SSA antibody positivity and ILD (OR = 2.781, 95% CI: 1.413–4.350, P< 0.001). At the same time, MR-Egger fitted a linear relationship between erythrocyte sedimentation rate (ESR) (95% CI: 1.257–5.894, P= 0.002), C-reactive protein (CRP) (95% CI: 2.433–6.935, P= 0.001), and ILD. Additionally, heterogeneity testing with IVW and MR-Egger regression indicated no heterogeneity, and MR-Egger regression intercept and MR-PRESSO testing suggested minimal influence of gene pleiotropy on the results, without non-specific SNPs identified in the leave-one-out analysis. CONCLUSION: A positive causal relationship may exist between anti-Jo-1 antibody positivity, anti-SSA antibody positivity, elevated ESR, elevated CRP, and ILD.
Pedicled ALT-flap for soft tissue reconstruction in the trochanteric area
Authors: Vater Adrian Matthias , Lamby Philipp , Moncher Johanna , Schmidt Karsten , Jordan Martin , Jakubietz Michael , Meffert Rainer , Jakubietz Rafael
Published: June 2024

BACKGROUND: Coverage of soft tissue defects following surgery at the trochanteric area is challenging. Revision surgery in case of compromised wound healing may lead to soft tissue defects requiring reconstruction with pedicled or free flaps. Previous access to the hip joint may jeopardize neurovascular structures relevant to the flap. OBJECTIVE: In this study, we evaluated if the use of a pedicled anterior lateral thigh (ALT) flap is a valuable option for soft tissue reconstruction. METHODS: In this retrospective study, seven patients were included. Defect etiology was tumor resection in one case, screw osteosynthesis in another case and total hip arthroplasty in three cases. All patients underwent reconstruction by proximal pedicled anterior lateral thigh (ALT) flap. RESULTS: Pedicled ALT flap was a safe procedure in all cases. One patient showed delayed wound healing with need for additional surgery. No further complications were observed. CONCLUSIONS: Pedicled ALT flap transfer represents a reliable option for soft tissue coverage in the trochanteric area after primary surgery such as hip arthroplasty, osteosynthesis or tumor resection.
Comparative analysis of hearing loss caused by steady-state noise and impulse noise
Authors: Fan Boya , Wang Gang , Wu Wei
Published: June 2024

BACKGROUND: Varied noise environments, such as impulse noise and steady-state noise, may induce distinct patterns of hearing impairment among personnel exposed to prolonged noise. However, comparative studies on these effects remain limited. OBJECTIVE: This study aims to delineate the different characteristics of hearing loss in workers exposed to steady-state noise and impulse noise. METHODS: As of December 2020, 96 workers exposed to steady-state noise and 177 workers exposed to impulse noise were assessed. Hearing loss across various frequencies was measured using pure tone audiometry and distortion product otoacoustic emission (DPOAE) audiometry. RESULTS: Both groups of workers exposed to steady-state noise and impulse noise exhibited high frequencies hearing loss. The steady-state noise group displayed significantly greater hearing loss at lower frequencies in the early stages, spanning 1– 5 years of work (P < 0.05). Among individuals exposed to impulse noise for extended periods (over 10 years), the observed hearing loss surpassed that of the steady-state noise group, displaying a statistically significant difference (P < 0.05). CONCLUSION: Hearing loss resulting from both steady-state noise and impulse noise predominantly occurs at high frequencies. Early exposure to steady-state noise induces more pronounced hearing loss at speech frequencies compared to impulse noise.
Sleep quality and the need for recovery among nurses working irregular shifts: A cross-sectional study
Authors: Albakri Uthman , Smeets Nick , Drotos Elizabeth , Kant IJmert , Gabrio Andrea , Meertens Ree
Published: June 2024

BACKGROUND: Shift work affects the mental and physical health of nurses, yet the effect of working irregular shifts on sleep and its association with the need for recovery is under-explored. OBJECTIVE: The purpose of this study was to investigate the sleep quality of nurses working irregular shifts, including night shifts, and to determine whether sleep quality is associated with the need for recovery. METHODS: This cross-sectional study included 405 nurses working irregular shifts. Data were collected using an online questionnaire that included sociodemographic characteristics, the Sleep-Wake Experience List, sleep problems, sleep duration, and the Need for Recovery scale. Data analyses included descriptive statistics, chi-square tests, t-tests, logistic and multiple linear regressions. RESULTS: Nurses who worked irregular shifts had poor sleep quality. Those who also worked night shifts, had significantly poorer sleep quality and experienced more difficulties in daily functioning than those who did not work night shifts. Sleep quality was significantly associated with the need for recovery and this remained so after controlling for confounding variables (β= .554, p = .001). CONCLUSION: The findings indicate that in nurses who work irregular shifts, the sleep quality is low. In this group, the sleep quality in nurses who work night shifts is lower than in nurses who do not work night shifts. Furthermore, better sleep quality was associated with lower need for recovery. These findings suggest that improving sleep quality in nurses working irregular shifts may lower their need for recovery, which may improve health, and reduce burnout and sickness absence.
Impacts of demographic factors and the COVID-19 pandemic on job stress in Japanese childcare workers
Authors: Matsuda Yuko , Hamada Shoko
Published: June 2024

BACKGROUND: Japan has a shortage of childcare personnel, and the high levels of stress causing turnover in childcare workers must be urgently resolved. However, there is a lack of knowledge regarding the characteristics and influencing factors of job stress in Japanese childcare workers. OBJECTIVE: This study aimed to evaluate the job stress of childcare workers and explore the influence of demographic factors and the COVID-19 pandemic on such stress. METHODS: The data were collected through an Internet survey from 2,472 respondents. A 23-item version of the Brief Job Stress Questionnaire was used to measure occupational stress in childcare workers. The instrument is recommended in the stress-check program implemented as a mental health measure in workplaces in Japan. RESULTS: The percentage of childcare workers with high stress exceeded that of general workers. Multiple regression analyses showed that the only factor affecting all job stressors and social support was the fear of contracting COVID-19. Job stressors and the COVID-19 pandemic had a significant large effect on stress responses. Additionally, being married and having children moderated childcare workers’ stress. CONCLUSIONS: This study provided basic data regarding job stress in Japanese childcare workers and compared them with those of other professionals. In the future, it will be necessary to clarify how stress is related to turnover intention and turnover in Japanese childcare workers to promote their career continuity.