bluuebunny/crossref_metadata_2025 huggingface dataset:
Health insurance status and outcomes in children, adolescents, and young adults: a systematic review and meta-analysis
Authors: Huang Congyang , Liu Hanshan , Hu Honglian , Jia Li , Hu Suyun
Published: August 2021

Background. The impacts of health insurance status on survival outcomes in children, adolescents, and young adults (aged 0-39 years) with malignant tumors have not been addressed in depth. The present study aimed to identify significant relationships of health insurance condition with overall survival or all-cause mortality among children (age 0-14 years) and adolescents and young adults (AYAs, age 15-39 years) with malignant tumors.
Methods. PubMed, Wiley Cochrane Central Register of Controlled Trials, Econlit, CINAHL, Web of Knowledge, PsychInfo, Business Source Premier, ProQuest Dissertation & Theses Database, and SCOPUS were systematically searched from inception to February 29, 2020 with no language restriction. All related articles comparing the effect of health insurance status on the risk of overall survival and the risk of all-cause mortality in malignant conditions affecting children and AYAs were identified. Pooled risk ratios (RRs) and 95% confidence intervals (CIs) were computed using a random- or fixed-effect model as per the heterogeneity evaluated using Cochran`s Q and I < sup > 2 < /sup > statistics.
Results. Fourteen studies including 149,680 individuals were selected for this meta-analysis. The pooled RR for all-cause mortality with insurance versus without insurance was 0.78 (95%CI, 0.71-0.86; I2=33.7%). Among the insurance types, patients with private insurance presented with a lower all-cause mortality (RR 0.70, 95% CI 0.60-0.82), with considerable heterogeneity (I2=83.3%).
Conclusions. The findings of this review suggest that a lack of or insufficient insurance is related to all-cause mortality of AYAs with malignant cancers. Strategies aimed at identifying causality and reducing disparities are warranted.
The causes of parental vaccine refusal: results of a survey from Giresun, Turkey
Authors: Terzi Özlem , Gülen Elif Nur , Dündar Cihad
Published: August 2021

Background. While efforts have raised immunization levels in developing countries, high rates of vaccine refusal in both developing and developed countries are causing concern worldwide. We aimed to determine the causes of vaccine refusal among parents refusing or postponing the vaccination of their children.
Methods. This descriptive, cross-sectional study was performed in the Giresun province of Turkey. The study population included families who were unwilling or refused to vaccinate at least one of their children under the scope of the Turkey Enhanced Program of Immunization. Data were obtained during the year 2018 by face-toface interviews with each vaccine hesitant parent (VHP).
Results. Vaccine refusal incidence was 1.2% in the year 2018. In 8 (14.8%) of the children, the vaccination was recorded to be postponed due to health problems, while 46 (85.2%) children were not vaccinated due to parental vaccine refusal. Two-thirds of unvaccinated children were living outside the province center of Giresun. The parents consisted of young adults whose average age was 30.6±6.6 years. VHPs were mostly university graduates (61.1% of mothers-70.3% of fathers). While at least one of the VHPs was a religious official in 24.1%, at least one of the either VHP was a teacher in 20.3%. The most common reasons for vaccine refusal were `fear of vaccine side-effects` (55.6%), and `problems in previous vaccinations` (33.3%). In 44.4 % of refusal cases, no specific reason was stated.
Conclusions. Primary healthcare providers, who are in close contact with parents, have an important role to provide the right health information. Various in-service training can be provided to improve the communication skills of healthcare providers. In these training sessions, besides comprehensive information about vaccines, it should be aimed to provide parents with the ability to understand their concerns, to approach them sensitively and to present the information they need effectively.
Outbreak of late-onset Group B Streptococcal disease with serotype Ib in a Neonatal Intensive Care Unit
Authors: Horie-Ota Hiroko , Ikeda Kazushige
Published: August 2021

Background. Hospital outbreaks of invasive group B streptococcus (GBS) infection are rare. There are only a few published reports of late-onset GBS outbreaks in neonatal intensive care units (NICUs). We report here three cases of late-onset GBS in our NICU.
Case. Three preterm very low birth weight (VLBW) infants born at 24 -27 weeks gestation developed lateonset GBS sepsis within four weeks. Two asymptomatic GBS carriers were identified in the NICU prior to the outbreak. Tests of maternal rectovaginal GBS colonization were negative in all three cases; as such, vertical transmission was unlikely. All three GBS isolates were capsular serotype 1b, with comparable antibiotic susceptibility profiles.
Conclusion. Preterm delivery and VLBW are associated with an increased risk of invasive late-onset GBS infection. This report underscores the ongoing risk of nosocomial transmission of GBS in the NICU.
Facial colliculus syndrome due to a Herpes simplex virus infection following Herpes labialis
Authors: Bodur Muhittin , Toker Rabia Tütüncü , Özmen Abdullah Hakan , Okan Mehmet Sait
Published: August 2021

Background. The facial colliculus is an elevated area that is formed by fibers from the motor nucleus of the 7`th cranial nerve as they loop over the abducens nucleus. Clinical signs and symptoms of facial colliculus lesions occur primarily due to injury to the abducens nerve nucleus, the facial nerve fibers around the abducens nucleus, paramedian pontine reticular formation, and the medial longitudinal fasciculus. The etiology of facial colliculus lesions varies by age. While tumors, demyelinating lesions, and viral infections can be involved in young individuals` etiology, vascular ischemia is a common causative factor in older people.
Case. In this paper, we present a case of facial colliculus syndrome due to its rare occurrence in a young patient; who developed the signs and symptoms after a herpes infection.
Conclusion. Facial colliculus syndrome is rare and the treatment is based on etiology.
PENERAPAN TEKNOLOGI PENGOLAHAN DODOL SIRSAK PADA KELOMPOK PROGRAM KELUARGA HARAPAN (PKH) KELURAHAN PAYOBASUNG, KECAMATAN PAYAKUMBUH TIMUR, KOTA PAYAKUMBUH
Authors: Ermiati Ermiati , Zebua Elva Amurita , Agustina Agustina , Syahrul Syuryani , Evawati Evawati
Published: August 2021

Sirsak merupakan salah satu komoditi yang banyak dijumpai di pekarangan masyarakat di Kelurahan Payobasung Kecamatan Payakumbuh Timur, Kota Payakumbuh. Pengolahan dan pemanfaatan sirsak oleh masyarakat di Kelurahan Payobasung ini masih sangat minim dan terbatas. Sirsak dapat diolah menjadi aneka makanan, salah satunya adalah dodol. Pengolahan dodol sirsak dapat dilakukan dengan cara pemasakan yang sederhana dan menggunakan peralatan yang sederhana, sehingga dapat diaplikasikan pada industri skala rumah tangga. Berdasarkan hal tersebut, maka dilakukan kegiatan pengabdian dan pendampingan terhadap kelompok PKH Kelurahan Payobasung. Kegiatan ini bertujuan untuk meningkatkan wawasan dan keterampilan peserta dalam mengolah sirsak menjadi dodol sirsak, dan mengarahkan keterampilan tersebut untuk menghasilkan pendapatan dan meningkatkan perekonomian keluarga. Pendampingan dilakukan dengan memberikan sosialisasi, pelatihan dan demo mengenai teknologi pengolahan dodol sirsak mulai dari persiapan bahan baku hingga proses pengemasan, serta usaha-usaha pemasaran kepada para peserta pelatihan. Hasil kegiatan ini adalah adanya peningkatan wawasan, keterampilan peserta mengenai pembuatan dodol sirsak, dan diharapkan ada peningkatan pendapatan bagi keluarga penerima PKH di Kelurahan Payobasung.

Kata kunci: Dodol, Sirsak, Komoditi Pekarangan

ABSTRACT

Soursop is a garden commodity that is often found in community’s yard and garden of Payobasung Village, Payakumbuh Timur Sub-District, Payakumbuh City. The processing and utilization of soursop by Payobasung Village community was minimal and limited. Soursop can be processed into various foods, including dodol. The processing of soursop dodol can be done by simple cooking and use simple equipment, so can be applied on a household scale industry. Based on this background, community service and assistance activities were carried out for PKH groups of Payobasung Village. The aims of this activity were to increase the perception and skills of participants in processing soursop into soursop dodol, and directing their skills to generate income and improve the family economy. The assistance activity was done by providing socialization, training and demonstration about the technology of soursop dodol, starting from the preparation of raw materials to the packaging process, as well as marketing efforts to the training participants. The results of this activity indicated an increase in participants’ perception and skills regarding making soursop dodol, and it is hoped that there will be an increase in income for PKH recipient families in Payobasung Village.

Keywords: Dodol, Soursop, Garden Comodity
PERUBAHAN PARADIGMA DALAM PANDEMI COVID 19 DAN ERA REVOLUSI INDUSTRI 4.0: Suatu Langkah Pengenalan pada Petani Sindang Jati Curup
Authors: Sri Dewi , K. Feby Astrid , Sulistyawati Maria F. S. , Romlah Romlah , Sari Anjelina Puspita
Published: August 2021

UMKM merupakan pelaku ekonomi yang mendukung perekonomian negara memiliki banyak kendala dalam usaha peningkatan kinerja perekonomiannya. Penghambat bagi mereka umumnya dikarenakan belum optimalnya kemampuan dalam berwirausaha. Dalam pengabdian dosen kali ini target yang ingin dicapai adalah merubah mindset, mengajarkan bagaimana membuat keuangan keluarga terkendali, demikian juga dalam menjaga kesehatan dalam era pandemi Covid 19. Hal yang tidak kalah penting adalah membukakan wawasan mengenai kemungkinan untuk melakukan ekonomi kreatif dalam upaya meningkatkan perekonomian keluarga.

Kata kunci: Mindset, Keuangan Keluarga, Kesehatan, Ekonomi Kreatif

ABSTRACT

SMEs are economic actors that support the coutry’s economy and face many obstacles in effots to improve economic performance. Most of the obstacles for them due to their inadequate entrepreneurial skills. In this training, the target to achieved is to change the mindset, teach how to keep family finance under control, as wel as maintaining health in the era of teh Covid 19 pandemic. It is also important to open up insignts about the possibility of carrying out a creative economy in an effort to improve the family economy.

Keywords: Mindset, Family Finances, Health, Creative Economy
PELATIHAN PEMBUATAN MEDIA PEMBELAJARAN BERBASIS ANDROID SEBAGAI SARANA PEMBELAJARAN JARAK JAUH
Authors: Wiyanti Endang , Solihatun Solihatun , Dinihari Yulian
Published: August 2021

Pengabdian kepada masyarakat ini adalah memberikan pelatihan pembuatan media pembelajaran berbasis android sebagai sarana pembelajaran jarak jauh di SMA Islam Terpadu Ar-Ridwan di wilayah Jati Asih, Bekasi.Mengingat pembelajaran saat ini masih melalui daring Pembelajaran Jarak Jauh (PJJ). Adapun metode yang digunakan yaitu metode ceramah, dikombinasikan dengan metode ceramah plus, tanya jawab, dan tugas. Metode ceramah plus diskusi dan praktik pengunduhan software.Khalayak sasaran dalam pelaksanaan kegiatan ini adalah guru mitra abdimas.Implikasi dari kegiatan ini adalah (1) Dapat membuat media pembelajaran sesuai dengan kebutuhan, tanpa mengharuskan para guru mempunyai skill atau keterampilan koding; (2) Memungkinkan para guru untuk membuat media pembelajaran yang bersifat interaktif.Hasil kegiatan yakni guru merasa puas karena mempunyai solusi untuk memudahkan mereka dalam mengajar jarak jauh seperti sekarang dan memberikan gambaran pembuatan media untuk pembelajaran mobile atau mobile learning yaitu dengan aplikasi SAC (Smart Apps Creator 3.0).

Kata Kunci: Media Pembelajaran berbasis android, Pembelajaran Jarak Jauh, aplikasi SAC (Smart Apps Creator 3.0).

ABSTRACT

This community service is to provide training in the creation of android-based learning media as a means of distance learning at SMA Islam Terpadu Ar-Ridwan in Jati Asih area, Bekasi. Considering the current learning is still through online Distance Learning (PJJ). The method used is the lecture method, combined with the plus lecture method, q&A, and tasks. Lecture methods plus discussion and software downloading practices. The target audience in the implementation of this activity is the teacher partner abdimas. The implication of this activity is (1) Can make learning media according to needs, without requiring teachers to have coding skills or skills; (2) Enable teachers to create interactive learning media. The result of the activity is that teachers are satisfied because they have a solution to facilitate them in teaching remotely as they are now and provide an overview of the creation of media for mobile learning that is with sac application (Smart Apps Creator 3.0).

Keywords: Android-based Learning Media, distance Learning, SAC apps (Smart Apps Creator 3.0)
SOSIALISASI PENCEGAHAN DAN PENGADAAN SAPRAS PENCEGAHAN COVID 19 DI KECAMATAN KEMILING KOTA BANDAR LAMPUNG
Authors: Sari Novita , Saputra M. , Aswin Aswin , P Avitha , C Mega
Published: August 2021

Covid-19 merupakan penyakit pernapasan akut yang disebabkan oleh virus corona jenis baru. Penyakit ini pertama kali merebak di Wuhan, Cina lalu menyebar hampir ke seluruh dunia dan menyebabkan pandemi global. Penyakit ini menyerang semua golongan, dewasa, lansia, maupun anak-anak. Semua lapisan masyarakat dari mulai dewasa hingga anak-anak perlu mendapatkan edukasi yang mudah dipahami mengenai Covid19 dan cara-cara pencegahannya. Hal ini yang menjadi dasar dilaksanakannya praktek kerja pengabdian masyarakat IIB Darmajaya. Tujuan kegiatan ini adalah untuk ikut aktif dalam upaya pencegahan virus Covid-19 dengan memberikan sosialisasi tentang Covid-19 dan upaya pencegahannya melalui pembagian APD dan juga pembagian tempat cuci tangan kepada masyarakat Kelurahan Pinang Jaya, Kecamatan Kemiling, Kota Bandar Lampung. Kegiatan ini dilakukan bermitra dengan masyarakat Kelurahan Pinang Jaya . metode yang dipergunakan adalah dengan cara penyuluhan dan sosialisasi tentang pencegahan Covid-19, pengadaan  sarana prasarana pencegahan Covid 19. Hasil dari pengabdian ini adalah masyarakat dapat memahami lebih jauh mengenai virus Covid 19 ini sehingga masyarakat dapat turut serta melakukan upaya pencegahan penularan Covid-19 dimulai dari diri mereka masing-masing.

Kata Kunci: Pengabdian, Covid-19, Pandemik, Sosialisasi, Edukasi

ABSTRACT

Covid-19 is an acute respiratory disease caused by a new type of corona virus. This disease first broke out in Wuhan, China then spread almost throughout the world and caused a global pandemic. This disease attacks all groups, adults, the elderly, and children. All levels of society from adults to children need to get education that is easy to understand about Covid19 and ways to prevent it. This is the basis for implementing IIB Darmajaya community service work practices. The purpose of this activity is to actively participate in efforts to prevent the Covid-19 virus by providing socialization about Covid-19 and prevention efforts through the distribution of PPE and also the distribution of hand washing facilities to the people of Pinang Jaya Village, Kemiling District, Bandar Lampung City. This activity is carried out in partnership with the people of Pinang Jaya Village. The method used is by means of counseling and socialization about the prevention of Covid-19, the provision of infrastructure for preventing Covid-19. of themselves.

Keywords: Community Service, Covid-19, Pandemic, Socialization, Education
Protein and iron intake adequacy among high school girls in Depok, Indonesia
Authors: Khoirunnisa Meirina , Devaera Yoga , Fahmida Umi , Witjaksono Fiastuti , Prafiantini Erfi
Published: August 2021

Introduction: Iron deficiency anemia is the most common type of anemia among adolescent girls. The prevalence of anemia among pregnant women increased from 2013 to 2018, and females age 15-24 years had the highest prevalence of anemia. Therefore, knowing the baseline status of protein and iron intake —particularly animal-sourced protein as the main source of heme iron—is important to design future intervention program. Thus, this study was aimed to assess the protein and iron intake adequacy of High School girls in Depok, Indonesia.
Methods: 211 girls from Senior High School in Depok, Indonesia participated in this study. Subjects were selected using a multi-stage random sampling method. A questionnaire was administered to obtain general characteristics.  Dietary intake data were obtained using a 3-day non-consecutive 24hr recall 1 weekend 2 weekdays interview. Anthropometric status was measured and calculated. Data were analyzed using IBM SPSS Statistics 20. Spearman’s correlation (significance p<0.05) was used to determine the factors related to protein and iron intake.
Results: This population had inadequate intake of energy (97.2%), protein (59.7%), and iron (98.6%). However, intake of fat was higher than recommended in 59.2% of participants. Protein and iron intake were not correlated with age, father’s education, mother’s education, and the number of household member.
Évaluation des caractéristiques fonctionnelles et rhéologiques des farines d'igname pilée instantanées (Dioscorea rotundata) obtenues à partir des tubercules des cultivars utilisés comme parents dans un programme de sélection au Bénin
Authors: Fakorede Jeannette , Badoussi Marius Eric , Loko Yêyinou Laura Estelle , Sanoussi Faouziath , Dassou Gbèblonoudo Anicet , Tchekessi Célestin , Yahou Innocent Bokossa , Dansi Anagonou Alexandre
Published: August 2021

Description du sujet. En Afrique de l’Ouest, les tubercules d’igname sont principalement consommés sous forme pilée. Cependant, vu la forte périssabilité des tubercules frais, la consommation de l’igname pilée tout le long de l’année est une préoccupation majeure. La transformation des tubercules en produits stables tels que la farine instantanée et pouvant donner une pâte ayant des caractéristiques similaires à celles de l’igname pilée est devenue une priorité. Objectifs. Évaluer les propriétés fonctionnelles et rhéologiques des farines d’igname pilée instantanées (InstAgoun) produites à partir de 48 cultivars utilisés comme parents dans un programme de sélection sur les ignames au Bénin. Méthode. Les farines issues des 48 cultivars d’igname ont été caractérisées par rapport à leur couleur et leurs propriétés fonctionnelles et rhéologiques en utilisant des méthodes standardisées. Résultats. Les résultats ont montré que le rendement de production en farine (14,7–27,9 %), la couleur (L* : 70,1–83,9 ; a* : -1,2—1,6 ; b* : 0,8–13,6), la solubilité (6,4–11,9 %), la viscosité au pic (1 048–4 376 cPs), la viscosité finale (1 568–6 251 cPs), la viscosité de maintien (875–4 004 cPs), la rupture de viscosité (14–592 cPs), le recul de viscosité (395–2 418 cPs), le temps au pic de viscosité (5–8 min) et la température de gélatinisation de l’amidon (73–93 °C) des farines produites ont varié significativement en fonction des cultivars d’igname. Cependant, aucune différence significative n’a été observée au niveau du pouvoir de gonflement des farines dérivées des différents cultivars qui a varié de 3,2 à 5,1 g·g-1. Au regard des caractéristiques fonctionnelles et rhéologiques, huit cultivars prometteurs (Singor, Parayobou, Agbaobé, Portchahabim, Tarayè, Tchée, Anklouman, Kpagninan) ont été identifiés comme les plus aptes à la production de la farine d’igname pilée instantanée. Conclusions. Une introduction effective de ces huit cultivars prometteurs dans des programmes d’amélioration variétale pourrait permettre de générer des variétés qui répondront aux exigences de qualité des différents acteurs, à savoir les producteurs, les transformateurs et les consommateurs pour l’amélioration de la chaine de valeur de l’igname en République du Bénin
Critical period of weeds interference in pineapple (Ananas comosus [L.] Merr.) crops
Authors: Oliveira Silvana Pimentel de , Santos Jefferson Costa , Leite Bruna Nogueira , Santos Géssica Aline Nogueira dos , Silva José Ferreira da
Published: August 2021

Description of the subject. In crop-weed competition, some periods are critical because they may interfere with the crop production capacity. Therefore, knowing these periods is crucial when deciding on the best time for control and preparation of the Integrated Management Program. Objectives. To determine the Period Prior to Interference, Total Period for Interference Prevention, and the Critical Interference Period in pineapple cultivation. Method. The experimental design consisted of randomized blocks in 2 x 15 factorial arrangement, four replications, and two management systems: weeds control and crop-weeds coexistence; 15 increasing periods of 30 days each after planting: 0, 30, 60, 90, 120, 150, 180, 210, 240, 270, 300, 330, 360, 390, 420. In the control treatments, since planting, manual weeding (with hoe) and mechanical weeding (with brush cutter) were done during increasing periods of time, and in the coexistence treatments, the weeds lived together with pineapple plants and, at the end of each period, weeds control was made with mechanical and chemical weeding. Results. The best yields were achieved in the periods of less coexistence with weeds. The critical periods for interference prevention with 5 and 10% of yield losses were 259 and 204 days, respectively. Conclusions. The critical period for interference prevention lasted 14-259 days after planting of the pineapple offsets.
Phénologie de Cola millenii K.Schum. au Bénin
Authors: Lawin Iboukoun Fidèle , Salako Kolawolé Valère , Fandohan Adandé Belarmain , Assogbadjo Achille Ephrem , Ouinsavi Christine Adjokè Ifètayo Nougbodé
Published: August 2021

Description du sujet. La compréhension des facteurs influençant les phénophases des plantes d’importance socio-économique est essentielle pour leur gestion durable. Cola millenii est un arbre dont les fruits sont comestibles. Objectifs. La présente étude a analysé les différentes phénophases de l’espèce le long d’un gradient climatique au Bénin. Méthode. Les évènements de feuillaison, floraison et fructification ont été observés au milieu et à la fin de chaque mois (environ chaque 15 jours) durant deux ans dans huit phytodistricts distribués entre la zone guinéenne et la zone soudano-guinéenne du Bénin. Résultats. Dans les deux zones climatiques, C. millenii porte des feuilles toute l’année, mais l’intensité de la feuillaison varie au cours de l’année. On observe une forte chute de feuilles de janvier à mars. Cola millenii fleurit d’octobre à avril (saison sèche). Un décalage d’un mois a été observé dans le phytodistrict du Borgou-Sud où la floraison a démarré en novembre. Le pic de la floraison a été constaté en décembre. La fructification s’étend de novembre (nouaison) à juillet (saison sèche à mi-saison pluvieuse). Un décalage d’un mois a été également observé dans le phytodistrict du Borgou-Sud où la fructification a démarré en décembre. Le pic de fructification a été observé dans la période de février à juillet. Les fruits murissent de façon progressive dans cette période. La floraison et la fructification sont positivement corrélées avec la température maximale et négativement avec l’humidité relative de l’air. De même, la floraison est négativement corrélée avec la pluviométrie. Conclusions. Cette étude fournit des informations importantes pour une gestion durable de l’espèce dans les régions climatiques où elle est rencontrée.
Allogeneic Hematopoietic Stem Cell Transplantation in Fanconi Anemia
Authors:   Victor Babes University of Medicine and Pharmacy Timisoara, Romania, R Dumache , A Lascu ,   Victor Babes University of Medicine and Pharmacy Timisoara, Romania, V Ciocan ,   Victor Babes University of Medicine and Pharmacy Timisoara, Romania, C Muresan ,   Victor Babes University of Medicine and Pharmacy Timisoara, Romania, A Mihailescu ,   Victor Babes University of Medicine and Pharmacy Timisoara, Romania, A Enache ,   Victor Babes University of Medicine and Pharmacy Timisoara, Romania, S Arghirescu ,   Victor Babes University of Medicine and Pharmacy Timisoara, Romania
Published: August 2021

Objective: Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) is the treatment of choice in patients with Fanconi Anemia (FA). The aim of our study is to evaluate the impact and benefits of allogenic matched donor HSCT in a case of a 12 year-old girl with FA, who displayed good clinical evolution following 2 months post-transplantation. Patients and Methods: In the pre-transplant phase, reference blood samples from the donor and recipient were collected on EDTA. The DNA from blood samples was extracted using an automated Maxwell® 48 RSC instrument (Promega, USA) with the Maxwell® RSC Whole blood DNA kit (Promega, USA). For DNA quantification, the PowerQuant System kit (Promega, USA) was used with the ABI 7500 Real-time PCR system (Applied Biosystems, USA). The amplification of the short tandem repeat markers was performed using the 24plex Investigator QS kit (Qiagen, Germany) on a ProFlex PCR System. Furthermore, the PCR products were separated and detected on an ABI 3500 Genetic Analyzer (Applied Biosytems, USA). Results: After 30 days of the transplantation, a Complete Chimerism (CC) was achieved with a full replacement by donor derived hematopoietic cells. After 60 days of the transplantation, the CC status was maintained with improvement of hematological findings. Conclusion: In FA, chimerism monitoring after HSCT provides useful informations of engraftment or possibility of post-transplantation complications such as graft versus host disease.
The Current Role of Immunotherapy in mCRPC: A Systematic Review
Authors:   Department of Oncology, Vejle Hospital, Vejle, Denmark, H Dalibey , TF Hansen ,   Department of Oncology, Vejle Hospital, Vejle, Denmark, AH Zedan ,   Department of Oncology, Vejle Hospital, Vejle, Denmark
Published: August 2021

Background: The development of immunotherapy has shown promising results in several malignant diseases, including prostate cancer, calling for a systematic review of the current literature. This review aims to evaluate the present data and prospects of immune checkpoint inhibitors in metastatic Castration Resistant Prostate Cancer (mCRPC). Methods: Articles were identified via a systematic search of the electronic database Pubmed, in accordance with the PICO process and following the PRISMA guidelines. Articles in English studying immune checkpoint inhibitors in patients with mCRPC published between March 2010 and March 2020 were eligible for inclusion. Endpoints of interest were Overall Survival (OS), Progression-Free Survival (PFS), clinical Overall Response Rate (ORR), and Prostate-Specific Antigen (PSA) response rate. Results: Ten articles were identified as eligible for inclusion. The studies primarily explored the use of Ipilimumab, a CTLA-4 inhibitor, and Pembrolizumab, a PD-1 inhibitor. These drugs were both used either as monotherapy or in combination with other treatment modalities. The largest trial included in the review demonstrated no significant difference in overall survival between the intervention and placebo. However, two studies presented promising data combing immunotherapy and immune vaccines. Grade 3 and 4 adverse events ranging from 10.1% to 82.3%, whit diarrhea, rash, and fatigue were the most frequently reported. Forty relevant ongoing trials were identified exploring immunotherapy with or without a parallel treatment modality. Conclusion: Overall, the current data shows that the effect of immune checkpoint inhibitors as monotherapy may have limited impact on mCRPC, and the results from ongoing combinational trials are eagerly awaited.
Impact of Second Wave of COVID-19 Pandemic: A Systematic Report of Tri-City Region of Chandigarh
Authors:   Department of Chemistry and Centre of Advanced Studies in Chemistry, Panjab University, Chandigarh, India, Chaudhary Savita
Published: August 2021

The second wave of COVID-19 pandemic has blown the tri-city of Chandigarh with terrible shock waves among the residents. Being one of the top-notch per capita income cities in India, Chandigarh was found to be more vulnerable in this second wave of COVID-19 pandemic. This second wave of pandemic has caused high inflow of patients from nearby states and produced supplementary burden on the health care facilities in the city beautiful. The central aim of this work is to highlight the impact of this second wave of pandemic on the health of residents. The study represents the impact of second wave of COVID-19 on tri-city of Chandigarh by focusing on the main points of, (1) reported active cases from February to May, 2021, (2) number of deaths during this phase, (3) challenges faced during this time and (4) management and governance measures during this time. This kind of study helps to comprehend the impacts of second wave on Chandigarh and emphasized on the major lessons that can be learned during this phase. In one hand the study discussed the vulnerable impact of pandemic on clinical and economical situation of city, whereas on other hand it explains the timely measures taken by the administration to curb the surge of this second wave. Overall, this second wave of pandemic lead to an outstanding opening for tri-city planners and policy architectures to take necessary and timely actions towards making the city more susceptibility to pandemics.
Pilot Assessment of a Rapid Test for the Detection of COVID-19 Disease by Using Latex Agglutination
Authors:   Laboratory of Neuroscience Elena Pessino Gómez del Campo, Madrid Scientific Park, Spain, A Cariaga-Martínez , KJ Gutiérrez ,   Laboratory of Neuroscience Elena Pessino Gómez del Campo, Madrid Scientific Park, Spain, R Alelú-Paz ,   Laboratory of Neuroscience Elena Pessino Gómez del Campo, Madrid Scientific Park, Spain
Published: August 2021

The rapid spread of the SARS-CoV-2 virus, which was declared a pandemic by the WHO in March 2020, has forced the scientific community to develop rapid detection tests in order to detect positive cases and implement the containment measures established in each country. In this regard, the techniques used (RTPCR, antibody test, etc.) have a number of drawbacks: require specialized personnel, in addition to, in some cases, obtaining results after 24 hours. Agglutination tests, widely used in the detection of viral particles, represent a simple, inexpensive and scalable method that would allow screening studies to be carried out in large populations. In this paper, we present a SARS-CoV-2 detection test based on this methodology, which could be considered as a complementary method to the techniques used for the detection of SARSCoV-2.
Green tea phytocompounds targets Lansterol 14-α demethylase against ergosterol biosynthesis in Candida glabrata
Authors: Priyanka Sirari  , Jigisha Anand  , Devvret  , Ashish Thapliyal  , Nishant Rai
Published: August 2021

Green tea is credited as one of the world’s healthiest drinks with enriched antioxidants. It is known for its multi-beneficial health benefits against diabetes, blood pressure, hypertension, gastro-intestinal upset and is bestowed with significant antimicrobial potential. There are previous scientific evidence highlighting the antifungal potential of green tea and has identified it as a potential inhibitor of non-albicans Candida species. Lansterol 14-α demethylase (Erg 11) or CYP51 protein belongs to the cytochrome P450 monooxygenase (CYP) superfamily. Erg 11 is involved in ergosterol biosynthesis and has a significant role in azole drug resistance in Candida glabrata. The present study attempted to identify the inhibitory potential of green tea phytocompounds against inhibition of Erg 11 in Candida glabrata using bioinformatics tool viz., autodock vina software. Out of 15 green tea phytocompounds investigated, the study identified, Rutin (-10.5 kcal) Kaempferitrin (-9.4kcal), Epigallocatechin gallate (-10kcal), Epicatechin gallate (-8.7kcal), and Coumaroylquinic acid (-8.6kcal) acid as the potent phytocompounds which showed significant molecular interaction with Erg 11 in Candida glabrata. In attribution to the constant emergence of azole-resistant isolates, this preliminary analysis therefore, indicated the potential of green tea phytocompounds against inhibition of non-albicans Candida specific candidiasis. However, further, in vitro antimicrobial efficacy of these phytocompounds, the dose regime, drug likeliness, and cytotoxic analysis are required to be investigated and validated.
15-49 Yaş Aralığındaki Kadınlarda Bel Ağrısı Sıklığı, Etkileyen Faktörler ve Bel Ağrısının Fiziksel Aktivite Düzeyi ile İlişkisinin Belirlenmesi
Authors: BAYBAŞİN Ceren , SAKA Günay
Published: August 2021

Amaç: Bu araştırma, Diyarbakır 16 nolu Aile Sağlığı Merkezi (ASM) bölgesinde yaşayan 15-49 yaş aralığındaki kadınlarda yaşam boyu, son bir yıl içindeki ve son üç ay içindeki bel ağrısı prevalanslarını tespit etmek amacıyla yapılmıştır. Materyal ve Metot: Araştırmanın evrenini, Diyarbakır 16 nolu ASM bölgesinde yaşayan 4800 kadın, örneklemini ise sistematik örnekleme yöntemi ile seçilip ulaşılabilen 392 kadın oluşturmaktadır. Bel ağrısının, kadınların yaşam kalitesini ne kadar etkilediğini belirleyebilmek için Oswestry Özürlülük İndeksi, fiziksel aktivite düzeyini belirlemek için ise Uluslararası Fiziksel Aktivite Anketi uygulanmıştır. Verilerin analizi, SPSS 22 (Statistical Package for the Social Sciences 22,0) programı ile yapılmıştır. Bulgular: Elde edilen bulgulara göre, yaşam boyu bel ağrısı sıklığı %70,4 olarak bulunmuştur. Kadınların Oswestry Özürlülük İndeksi puan ortalaması 12,5±6,4 bulunmuştur. Katılımcıların %56,9’u minimum aktif, %33,9’u ise inaktif çıkmıştır. İnaktif kadınlarda bel ağrısı sıklığı %94 bulunurken, çok aktif kadınlarda %38,9 olarak bulunmuştur. Fiziksel aktivite düzeyi arttıkça bel ağrısı görülme sıklığı azalmaktadır. Sonuç: Bel ağrısı ile ilgili olduğunu düşündüğümüz risk faktörlerinden medeni durum, yaş, vücut kitle indeksi, gebelik sayısı, egzersiz yapma durumu, ev işleri yapma durumu ile bel ağrısı sıklığı arasında anlamlı ilişkiler bulunmuştur. Bu bilgiler ışığında, risk faktörlerine yönelik gerekli önlemler alındığı takdirde kadınlarda bel ağrısı sıklığı azaltılabileceği sonucuna ulaşılmıştır.
Batı Marmara Bölgesindeki Bir Üniversite Hastanesinde Son Üç Yıllık Dönemdeki Jinekolojik Malignite Vakalarının Retrospektif Analizi
Authors: AKSU Sevde , PALAS KARACA Pelin , TAŞKIN Mine
Published: August 2021

Amaç: Çalışmada Batı Marmara bölgesinde bir üniversite hastanesinde opere edilen jinekolojik malignite vakalarının risk faktörleri açısından retrospektif değerlendirilmesi amaçlanmıştır. Materyal ve Metot: Araştırmanın gerçekleştirildiği hastanede Ağustos 2017-Ağustos 2020 tarihleri arasında kayıt sisteminden vakaların sosyo-demografik bilgileri, obstetrik ve jinekolojik anamnez, uygulanması kararlaştırılan tanı ve tedavi yöntemleri ile postoperatif histopatolojik bulguları incelenmiştir. Bulgular: Kadınların %64,2’sinin serviks kanseri iken %23,9’unun endometrium kanseri %11,9’unun ise over kanseri olduğu belirlenmiştir. Risk faktörleri incelendiğinde; servikal kanserli vakaların %35,6’sında ilk cinsel aktivite 18 yaş altı olup %64,3’ünün kötü hijyen koşullarına sahip olduğu, endometrium kanserli vakaların %38,5’inin beden kitle indeksi 30 kg/m2 üzerinde ve %48’inin en az bir kronik hastalığı olduğu, over kanserli vakaların ise %46,1’inin infertilite tedavisi aldığı belirlenmiştir.Sonuç: Bu çalışmanın sonucunda çalışmaya alınan vakaların başvuru yakınmaları ve risk faktörleri ile ilgili elde edilen veriler değerlendirildiğinde, özellikle çevresel risk faktörleri ve kişinin yaşam tarzının kanserlerin ortaya çıkmasında önemli etkisi olduğu saptanmıştır.
The Relationship Between Malnutrition Risk and Prognosis in Geriatric Patients Hospitalized for COVID-19
Authors: GÜNER Beytullah , SİVRİTEPE Ridvan , UÇAK BASAT Sema
Published: August 2021

Objective: We evaluated the effect of nutritional status on the prognosis of the disease in geriatric patients hospitalized due to COVID-19 disease.Materials and Methods: 110 patients over 65 years old were included. Malnutrition risk was assessed by Nutritional Risk Screening 2002 (NRS 2002). The patients were divided into two groups according to the NRS 2002 score (≥3 as group-1, <3 as group-2). Prognosis markers of the patients were recorded. Statistical significance level was set at p<0.05.Results: The study was conducted 110 patients (Man/Woman:51/59). In group-1, duration of hospitalization, tomography involvement, intubation rate and referral to intensive care, respiratory rate, leukocyte count, C reactive protein (CRP), ferritin, d-dimer levels were higher than group-2 (p<0.05). In group 1; 35 cases were discharged, 18 cases were transferred to 1st level intensive care, and 2 cases were transferred to 3rd level intensive care. In the group 2, 53 cases were discharged, and 2 cases were transferred to 1st level intensive care unit. There was a significant positive correlation between NRS 2002 score and age, respiratory rate, leukocyte, CRP, d dimer and days of hospitalization score (p<0.05).Conclusion: Malnourished patients have higher poor prognostic markers, longer hospital stay and more intensive care needs.
The Effect of Covid-19 Pandemic on Computed Tomography Evaluations in Pediatric Emergency Traumas
Authors: ILGAR Mehtap , MERT DOĞAN Güleç
Published: August 2021

Objective: The aim of this study was to compare the number of computed tomography (CT) examinations and pathologies of the pediatric patients admitted to the emergency department due to trauma during the pandemic with the compatible non-pandemic time period.Matarials and Methods: This study was a retrospective study of the patients aged 0-18 years, who admitted to the emergency department due to trauma and had CT imaging in 1-30 April 2020 and 1-30 April 2019.Results: In April 2020, 448 patients applied to the emergency department due to trauma. CT scans were performed to 138 of these 448 (30.8%) patients. In April 2019, 2416 patients applied to the emergency department due to trauma. CT scans were performed to 463 of these 2416 (19.1%) patients. No statistically significant difference was found between the patients, who underwent CT in April 2020 and 2019 by gender (p=0.324). A statistically significant difference was found between 2020 and 2019 by the age groups (p<0.001).Conclusion: This is neither the first nor the last pandemic the world has ever faced. It is very important to determine the differences in patient distribution and to prepare protocols and guidelines to be used during pandemics.
Sezaryen Sonrası Vajinal Doğum İsteği Bulunan Gebelerde Doğum Şekli ile Doğum Korkusu Arasındaki İlişkinin İncelenmesi
Authors: ESER Ahmet , YILMAZ ESENCAN Tuğba , KESKİN Semra
Published: August 2021

Amaç: Araştırma, sezaryan sonrası vajinal doğum isteyen miyad gebelerde doğum şekli ile doğum korkusu arasındaki ilişkiyi incelemek amacıyla yapılmıştır.
Materyal ve Metot:Araştırma, 37-41. gebelik haftasında sağlıklı doğum yapan 66 gebe ile gerçekleştirilmiştir. Veri toplama aşamasında Kişisel Bilgi Formu, Wijma Doğum Beklentisi/Deneyimi Ölçeği B versiyonu kullanılmıştır. Araştırmada elde edilen verilerin değerlendirilmesinde; ortanca, çeyrekler arası aralık ve Mann-Whitney U testi uygulanmıştır.
Bulgular: Araştırmaya katılanların %54,5’i 30 yaş ve üzerinde olup %53’ü sezaryen sonrası vajinal doğum yapmıştır. Araştırmaya katılanlar arasında sezaryen sonrası vajinal doğum ve sezaryen ile doğum gerçekleştirenlerin WDEQ-B puan skorları karşılaştırılmış doğum şekli ile doğum korkusu arasında istatistiksel olarak anlamlı bir ilişki bulunmamıştır (U:478,5 p: 0,41).
Sonuç: Sezaryan sonrası vajinal ile doğum isteği bulunan hastalarda doğum korkusu ile doğum şekli arasında anlamlı bir ilişki olmadığı saptanmıştır. Konu ile ilgili çalışma sayılarının yetersiz olması nedeniyle yeni çalışmaların yapılması önerilmektedir.
The role of Sildenafil and Bacillus clausii for the Prevention of Methotrexate Induced Mucositis: A Preclinical Study
Authors: KAYMAKCI Aytekin , GÜVEN Şirin , ZEMHERİ Itır Ebru , MİRAPOĞLU Semih Lütfi , ARPACIK Mehmet , ŞAHİN Ceyhan
Published: August 2021

Objective: Methotrexate (MTX) is a commonly used chemotherapeutic agent in clinical oncology practice and in treatment of autoimmune diseases. The major side effect during treatment is mucositis. Recently published studies reported that this effect may be due to direct intestinal epithelial injury and disturbance of intestinal microbiota. In this study, we aimed to characterize the intestinal histological changes caused by MTX and to investigate the effects and safety of Sildenafil and probiotic Bacillus clausii on intestinal mucositis in a rat model.
Materials and Methods: The rats were divided in 4 groups; Group1(n=8) received MTX + B. clausii, Group 2 (n=8) received only MTX, Group3 (n=8) received MTX + Sildenafil and Group 4 (n=7) was served as control (received no treatment).
Results: The rate of villus atrophy, villous fusion and erosion in the MTX + B. clausii group were found to be statistically significantly lower than in the MTX group and the MTX + Sildenafil group.
Conclusion: The study demonstrated the effect of B. clausii on repairing of intestinal mucosa after MTX-treatment. The better understanding of the effects of probiotics on intestinal mucosal protection may lead to new therapeutic approaches in chemotherapy-induced mucositis.
Factors Affecting the Age of Application in Children with Enuresis Nocturnal: A Multicentric Study from the Eastern of Turkey
Authors: DEMİR Murat , AVCİ Veli
Published: August 2021

Objective: Enuresis nocturna, which is common in childhood, can cause significant psychosocial problems if left untreated. In this study, it was aimed to examine the factors affecting the age of admission to the outpatient clinic in children with enuresis nocturna.Materials and Methods: Patients from five different centers were included in the study. The patients' age, gender, family structure, place of residence, occupational status of the mother, education level and income of the parents were obtained from the hospital records and by contacting the families by phone.Results: The mean age of the 162 patients included in the study was 9.41±3.24 years, 94 of whom were male. It was found that as the education level and income level of their parents increased, the age of referring to the polyclinic decreased significantly. In addition, it was observed that patients living in urban areas applied to the hospital earlier than rural patients.Conclusion: Factors such as the education level of the parents, place of residence and income level are important in terms of the time of admission to the outpatient clinic of patients with enuresis nocturna.
Attitudes of Medical Faculty Students towards Distance Education and Related Factors during the Pandemic Period
Authors: KÖSE Elif , EKERBİÇER Hasan , SHAHİM Abdul Majid , ÇAKMAK Ahmet , DERİCİ Alphan , HOŞSEVEN Aysun , KOÇER Enes , BAYRAK İrem Ülkü , BALÇIN Kübra , YILMAZ Mehmet Zahit , SHAHVALADOVA Narmin , BİLGİÇ Neslihan , EROL Nur Eda , SALLAM Omer , BÜLBÜL Rahime , UZUN Rana Betül , DEVECİ Seyide İmran , ÇELİK Yavuz , MAHYOUB Yunes , GÖKHAN Zeynep , OTURAK Gökhan
Published: August 2021

Objective: It is aimed to investigate the effect of distance education on medical faculty students, to determine the advantages and disadvantages of distance educationMaterials and Methods: Four hundred eighty-one (52.3%) of 919 medical faculty students participated in this descriptive study conducted on Sakarya University Faculty of Medicine students. The questionnaire form created by the researchers was sent to the students via Google forms. Evaluation of Views on Distance Education Scale (EVDES) was used to evaluate the views of the participants about distance education.Results: Sixty-three percent of the participants (303) were female, 37% (178) were male. The average age of the participants was 21.8 ± 2.02 years. While the maximum score from the EVDES is 90, the median score obtained by the participants is 46. The median score obtained by men from the EVDES was statistically significantly higher than the median score obtained by women (p = 0.016).Conclusion: Some characteristics such as female gender, being a semester student, attending less than half of the lessons, having problems with internet connection, having another individual taking distance education in the family negatively affected the views of the medical faculty students participating in the study about distance education.
FEIRA DE CIÊNCIAS DO ESTADO DO TOCANTINS: CONTRIBUIÇÕES PARA A EDUCAÇÃO CIENTÍFICA
Authors: Nogueira Leonardo Cipriano , Ferreira Gecilane , Sousa Nilciane Pinto Ribeiro de
Published: August 2021

Este trabalho traz apontamentos sobre as contribuições que as feiras de ciências podem proporcionar a educação científica no estado do Tocantins. Tendo como objeto de pesquisa a Feira de Ciências do estado do Tocantins – FECITO, que ocorre anualmente no município de Araguaína – TO, promovido na Universidade Federal do Tocantins, pelos cursos de licenciatura em ciências naturais, coordenado por um professor do curso de licenciatura em biologia. O objetivo geral constituiu-se em identificar as contribuições desses eventos para educação científica na educação básica no Tocantins, destacando como se deram essas contribuições ao longo das edições do evento, para tanto, foi desenvolvida uma pesquisa qualitativa fundamentada nos pressupostos metodológicos da análise documental e coleta de dados, examinados à luz da análise de conteúdo. A partir do qual construímos duas categorias, educação científica acadêmica e educação científica no ensino básico, ambas revelam as contribuições do evento em diferentes contextos ao longo dos anos de suas edições e, corroboram a promoção da interação de professores e alunos da educação básica, acadêmicos dos cursos de licenciaturas em ciências naturais e professores da universidade, em um ambiente propício à troca de experiência proporcionada pela FECITO, como identificado nas duas categorias que emergiram da análise dos dados.
Широкосмугова антена у вигляді відрізка коаксіального хвилеводу
Authors: Каращук Наталія Миколаївна , Манойлов В’ячеслав Пилипович , Мартинчук Петро Петрович , Терех Катерина Сергіївна
Published: August 2021

Антена у вигляді відкритого відрізка коаксіального хвилеводу в режимі хвилі типу  широко використовується як самостійний випромінювач. Особливістю такої антени є її погане узгодження з вільним простором. Для покращення узгодження антени у вигляді відрізка коаксіального хвилеводу застосовано діелектричний чвертьхвильовий трансформатор. Отримано формули (1)–(5) для розрахунку параметрів діелектричного чвертьхвильового трансформатора та представлено експериментальні дані, які підтверджують розрахунки. А саме: активної  (1) та реактивної  (2) зовнішніх провідностей відкритого кінця коаксіальної лінії; коефіцієнта відбиття хвилі в коаксіальній лінії  (4) і коефіцієнта корисної дії  (5). У таблиці 1 наведено значення результатів розрахунків геометричних розмірів та місця включення виготовлених зразків діелектричних чвертьхвильових трансформаторів, що підтверджені експериментально. Наведено розраховані та експериментально зняті графіки зміни коефіцієнта стоячої хвилі за напругою (КСХН) у смузі частот для різних типів діелектричних чвертьхвильових трансформаторів та діаграм спрямованості антени різних розмірів.