bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of Radiotherapy on Malfunctions and Battery Life of Cardiac Implantable Electronic Devices in Cancer Patients
Authors: Lisowski Dominik , Lutyj Paul , Abazari Arya , Weick Stefan , Traub Jan , Polat Bülent , Flentje Michael , Kraft Johannes
Published: October 2023

Purpose: This study analyses a large number of cancer patients with CIEDs for device malfunction and premature battery depletion by device interrogation after each radiotherapy fraction and compares different guidelines in regard to patient safety. Methods: From 2007 to 2022, a cohort of 255 patients was analyzed for CIED malfunctions via immediate device interrogation after every RT fraction. Results: Out of 324 series of radiotherapy treatments, with a total number of 5742 CIED interrogations, nine device malfunctions (2.8%) occurred. Switching into back-up/safety mode and software errors occurred four times each. Once, automatic read-out could not be performed. The median prescribed cumulative dose at planning target volume (PTV) associated with CIED malfunction was 45.0 Gy (IQR 36.0–64.0 Gy), with a median dose per fraction of 2.31 Gy (IQR 2.0–3.0 Gy). The median maximum dose at the CIED at time of malfunction was 0.3 Gy (IQR 0.0–1.3 Gy). No correlation between CIED malfunction and maximum photon energy (p = 0.07), maximum dose at the CIED (p = 0.59) nor treatment localization (p = 0.41) could be detected. After excluding the nine malfunctions, premature battery depletion was only observed three times (1.2%). Depending on the national guidelines, 1–9 CIED malfunctions in this study would have been detected on the day of occurrence and in none of the cases would patient safety have been compromised. Conclusion: Radiation-induced malfunctions of CIEDs and premature battery depletion are rare. If recommendations of national safety guidelines are followed, only a portion of the malfunctions would be detected directly after occurrence. Nevertheless, patient safety would not be compromised.
Mismatch Repair Deficiency Is a Prognostic Factor Predicting Good Survival of Opisthorchis viverrini-Associated Cholangiocarcinoma at Early Cancer Stage
Authors: Khuntikeo Natcha , Padthaisong Sureerat , Loilome Watcharin , Klanrit Poramate , Ratchatapusit Soontaree , Techasen Anchalee , Jareanrat Apiwat , Thanasukarn Vasin , Srisuk Tharatip , Luvira Vor , Chindaprasirt Jarin , Sa-ngiamwibool Prakasit , Aphivatanasiri Chaiwat , Intarawichian Piyapharom , Koonmee Supinda , Prajumwongs Piya , Titapun Attapol
Published: October 2023

Background: The mismatch repair (MMR) system prevents DNA mutation; therefore, deficient MMR protein (dMMR) expression causes genetic alterations and microsatellite instability (MSI). dMMR is correlated with a good outcome and treatment response in various cancers; however, the situation remains ambiguous in cholangiocarcinoma (CCA). This study aims to evaluate the prevalence of dMMR and investigate the correlation with clinicopathological features and the survival of CCA patients after resection. Materials and Methods: Serum and tissues were collected from CCA patients who underwent resection from January 2005 to December 2017. Serum OV IgG was examined using ELISA. The expression of MMR proteins MLH1, MSH2, MSH6 and PMS2 was investigated by immunohistochemistry; subsequently, MMR assessment was evaluated as either proficient or as deficient by pathologists. The clinicopathological features and MMR status were compared using the Chi-square test. Univariate and multivariate analyses were conducted to identify prognostic factors. Results: Among the 102 CCA patients, dMMR was detected in 22.5%. Survival analysis revealed that dMMR patients had better survival than pMMR (HR = 0.50, p = 0.008). In multivariate analysis, dMMR was an independent factor for a good prognosis in CCA patients (HR = 0.58, p = 0.041), especially at an early stage (HR = 0.18, p = 0.027). Moreover, subgroup analysis showed dMMR patients who received adjuvant chemotherapy had better survival than surgery alone (HR = 0.28, p = 0.012). Conclusion: This study showed a high prevalence of dMMR in cholangiocarcinoma with dMMR being the independent prognostic factor for good survival, especially in early-stage CCA and for patients who received adjuvant chemotherapy. dMMR should be the marker for selecting patients to receive a specific adjuvant treatment after resection for CCA.
Monitoring and Surveillance of Patients with Gastroenteropancreatic Neuroendocrine Tumors Undergoing Radioligand Therapy
Authors: Halfdanarson Thorvardur R. , Mallak Nadine , Paulson Scott , Chandrasekharan Chandrikha , Natwa Mona , Kendi Ayse Tuba , Kennecke Hagen F.
Published: October 2023

Radioligand therapy (RLT) with [177Lu]Lu-DOTA-TATE is a standard of care for adult patients with somatostatin-receptor (SSTR)-positive gastroenteropancreatic neuroendocrine tumors (GEP-NETs). Taking advantage of this precision nuclear medicine approach requires diligent monitoring and surveillance, from the use of diagnostic SSTR-targeted radioligand imaging for the selection of patients through treatment and assessments of response. Published evidence-based guidelines assist the multidisciplinary healthcare team by providing acceptable approaches to care; however, the sheer heterogeneity of GEP-NETs can make these frameworks difficult to apply in individual clinical circumstances. There are also contradictions in the literature regarding the utility of novel approaches in monitoring and surveilling patients with GEP-NETs receiving RLT. This article discusses the emerging evidence on imaging, clinical biochemistry, and tumor assessment criteria in the management of patients receiving RLT for GEP-NETs; additionally, it documents our own best practices. This allows us to offer practical guidance on how to effectively implement monitoring and surveillance measures to aid patient-tailored clinical decision-making.
Illuminating Histidine-Deficient Intracellular Environments: A Novel Whole-Cell Microbial Fluorescence Sensor
Authors: Li Xinyi , Li Zezhou , Zhao Meiping
Published: October 2023

Histidine is an essential amino acid with significant implications for human growth and neuromodulation. Its intracellular concentration, whether increased or decreased, can indicate different diseases. While various methods exist for measuring elevated histidine levels, there remains a significant lack of sensors capable of actively responding to histidine deficiency within cells and releasing strong signals. In this study, we exploited the high induction levels of the his operon in S. Typhimurium SL1344, a histidine auxotroph, within a histidine-deficient environment, to develop a specific bacterial sensor with sensitivity towards low histidine concentrations. By employing plasmid vectors with differing copy numbers, we developed two distinct bacterial fluorescence sensors, both capable of actively responding to histidine deficiency and emitting detectable fluorescence signals within either culture mediums or live cells. The SL1344-pGEX sensor, with a high copy number, exhibited remarkable sensitivity and selectivity to histidine in the range of 0 to 50 μM. Notably, even a minimal addition of histidine (approximately 2.5 μM) to the M9 medium led to observable fluorescence reduction, rendering it highly suitable for monitoring histidine-deficient cellular environments. In contrast, the low-copy-number SL1344-pSB3313 sensor exhibits a broader response range, capable of tracking more extensive shifts in histidine concentrations. These sensors allow for sensitive in situ detection of intracellular histidine concentrations in various live cells, particularly responding to real-time changes in cellular histidine levels. This provides a powerful tool for investigating histidine deficiency-related biological processes, the mechanisms of associated diseases, and the assessment and optimization of therapeutic strategies.
Thyroxine Quantification by Using Plasmonic Nanoparticles as SERS Substrates
Authors: De Leon Portilla Paulina , González Ana L. , Sanchez-Mora Enrique
Published: October 2023

Functionalized Au and Ag nanoparticles (NPs) with ascorbic and tannic acid, respectively, were used as SERS substrates (SS). Several SS were fabricated with different loads of metal NPs deposited on silicon wafers. We focused on the thyroxine (T4) band at 1044 cm−1 and tracked its intensity and position at concentrations from 10 pM to 1 mM. For all SS, the band intensity decreased as the T4 concentration decreased. Additionally, the band shifted to larger wavenumbers as the NP loads increased. In the case of Au, the SS with the highest load of NPs, the minimum concentration detected was 1 μM. The same load of the Ag NP SS showed a better performance detecting a concentration of 10 pM, an outcome from a SERS-EF of 109. The NP spatial distribution includes mainly isolated NPs, quasi-spherical clusters, and semi-linear arrays of NPs in random orientations. From the numerical simulations, we conclude that the hot spots at the interparticle gaps in a linear array of three NPs are the most intense. The Ag NP SS demonstrated good sensitivity, to allow the detection of pM concentrations. Therefore, its complementation to any immunoassay technique provides an interesting alternative for point-of-care implementations, such as test strips.
A Hotspot of Subterranean Biodiversity on the Brink: Mo So Cave and the Hon Chong Karst of Vietnam
Authors: Deharveng Louis , Le Cong Kiet , Bedos Anne , Judson Mark L. I. , Le Cong Man , Lukić Marko , Luu Hong Truong , Ly Ngoc Sam , Nguyen Tran Quoc Trung , Truong Quang Tam , Vermeulen Jaap
Published: October 2023

The southern part of the Mekong Delta Limestones of Vietnam (MDL-HC or Hon Chong karst) comprises numerous small limestone hills. It is a hotspot of biodiversity for soil and cave invertebrates. Here, we synthesize the results of biological surveys carried out in Hang Mo So, the richest MDL-HC cave for troglobionts, and in surrounding karsts. Methodologies for the ecological characterization of species are discussed, with emphasis on parallel sampling (external soil plus cave). Hang Mo So has 27 troglobionts, including many still undescribed. An additional 40 cave-obligate species are known from other caves of MDL-HC. Among them, several are expected to be found in Hang Mo So. Most troglobionts of MDL-HC are endemic. Several relictual taxa without close relatives in Southeast Asia occur in Hang Mo So and in MDL-HC, reflecting an ancient origin of the fauna. The reasons for this richness are uncertain, but the cause of its current destruction—quarrying—is all too evident. Most of the original 4 km2 of the MDL-HC karst has been destroyed or soon will be, ultimately leaving only 1.6 km2 unquarried. Endemic species linked to karst habitats are, therefore, under clear threat of extinction. The Hon Chong karst (MDL-HC) was listed among the ten most endangered karsts on the planet 25 years ago. Today it would probably top the list.
Genetic and Ecological Approaches to Introduced Populations of Pumpkinseed Sunfish (Lepomis gibbosus) in Southwestern Europe
Authors: Lambea-Camblor Angela , Morcillo Felipe , Muñoz Jesús , Perdices Anabel
Published: October 2023

Freshwater systems are among the most affected by the introduction of exotic species. The pumpkinseed sunfish Lepomis gibbosus, a centrarchid native to eastern North America, is listed among the top ten introduced freshwater fishes with the greatest ecological impact globally. Despite this, genetic and evolutionary studies of the species are still scarce. Here, we analyzed the genetic variability of introduced populations of L. gibbosus using three mitochondrial genes (COI, d-loop, and ND1). In addition, we used species distribution modeling to compare the niche of introduced versus native populations to assess the present and potential future distribution of the species under different climate change scenarios. Compared with the native populations, introduced ones present a lower level of genetic variability, indicating these populations originated from a small number of individuals from the native (Atlantic) population in the USA and Canada. The low variability was likely driven by a founder effect and subsequent bottleneck, as often occurs in invasive species. Our modeling results suggest not only that L. gibbosus modified its niche during the invasion process in Europe but also the possible global expansion of the species under future climatic conditions, which could facilitate its establishment in almost all continents.
Batch Simultaneous Saccharification and Fermentation of Primary Sludge at Very High Solid Concentrations for Bioethanol Production
Authors: Mendes Cátia V. T. , Rocha Jorge M. S. , Carvalho M. Graça V. S.
Published: October 2023

A sustainable industrial future involves the exploitation of renewable resources to obtain a wide diversity of products and energy and the decrease of waste generation. Primary sludge (PS) from pulp and paper mills is a lignocellulosic residue mainly consisting of cellulose and hemicelluloses that can be converted to bioethanol. In the present work, bioethanol was produced from untreated PS by simultaneous saccharification and fermentation (SSF). Studies were carried out on initial solid concentration, yeast inoculum percentage, cellulolytic enzyme dosage, and co-application of two enzyme complexes (cellulolytic NS 22192 and xylanolytic Cellic® HTec2, Bagsværd, Denmark). Increasing solid content up to 22% improved ethanol concentration (59.1 g L−1), productivity (1.97 g L−1 h−1), and yield (86.3%); however, at the maximum solid concentration (28%), both yield and productivity decreased. At the highest solid concentration, a decrease of 33% in the cellulolytic enzyme dosage was observed (compared to reference enzyme loadings). The co-application of the two enzyme complexes had a positive effect on PS conversion efficiency. When a preliminary scale-up strategy was implemented from 50 mL to 2.5 L at 22% solids concentration, similar results were obtained despite the initial mixing difficulties of the heterogeneous system.
Conflicts in Intergenerational Relationships and Patterns of Coordination among Chinese–African Families in Guangzhou
Authors: Zhou Yang
Published: October 2023

Through case studies of Chinese–African couples living together with Chinese parents, this paper examines conflict coordination within intergenerational relationships in the same living environment. Among intergenerational families living in China and Africa, intergenerational differences as well as family relationship issues are sometimes inevitable. In addition, different families employ varying methods in order to alleviate intergenerational tension and maintain harmony within the family. Through fieldwork, it was found that there are three types of intergenerational relations: regulation by an intermediary, formal democracy, and excessive participation. Although all three models attempt to balance intergenerational voices and decision-making power, the first two models are generally present in relatively stable family relationships, while the last model consists of relatively negative aspects that actually add fuel to the fire when family conflicts arise. Although young Chinese–African couples and elderly Chinese parents expect family relations to function well, the contradictions brought about by power imbalances not only hurt the parent–child relationship, but more importantly affect the intimate marriage relationship and the upbringing of the children.
Smoothness Evaluation Indices during Sit-to-Stand-to-Sit Motions in Healthy Older Females and after Hip Fracture Using an Accelerometer: A Pilot Study
Authors: Shimamura Takeshi , Ishikawa Hitoshi , Fujii Hiromi , Katoh Hiroshi
Published: October 2023

Background: Studies that quantify the quality of sit-to-stand-to-sit (STS) motions, particularly in terms of smoothness, are limited. Thus, this study aimed to investigate the possibility and usefulness of quality evaluation during STS motions. Methods: This cross-sectional study enrolled 36 females aged >60 years, including 18 females each in the healthy and hip fracture groups. Measurements were performed at two different speeds: five STS as fast as possible (STSF) and two seconds for each motion (STS2s). Indices of smoothness, including harmonic ratio (HR) and power spectrum entropy (PSE), were calculated and compared from the measured data in each of the three axial directions. Results: HR in the vertical direction was significantly higher in the healthy group (STSF: 3.65 ± 1.74, STS2s: 3.42 ± 1.54) than in the hip fracture group (STSF: 2.67 ± 1.01, STS2s: 2.58 ± 0.83) for STSF and STS2s. Furthermore, PSE for all directions and triaxial composites were significantly lower for STS2s (the healthy group (mediolateral (ML): 7.63 ± 0.31, vertical (VT): 7.46 ± 0.22, anterior–posterior (AP): 7.47 ± 0.15, triaxial: 7.45 ± 0.25), the hip fracture group (ML: 7.82 ± 0.16, VT: 7.63 ± 0.16, AP: 7.61 ± 0.17, triaxial: 7.66 ± 0.17)). Conclusions: This study suggests the usefulness of HR and PSE as quality evaluations for STS motions.
Aneurysmal Bone Cyst of the Pelvis in Children and Adolescents: Effectiveness of Surgical Treatment with Curettage, Cryotherapy and Bone Grafting
Authors: Andreani Lorenzo , Ipponi Edoardo , Serrano Elena , De Franco Silvia , Cordoni Martina , Bechini Elena , D’Arienzo Antonio , Parchi Paolo Domenico
Published: October 2023

Background: Aneurysmal bone cysts (ABCs) are benign but locally aggressive cystic lesions of the bone. Pelvic ABCs are extremely rare and hard to treat due to their high risk of local recurrence and the tough access to pelvic bones. Methods: In this retrospective study, we evaluated pediatric cases with pelvic ABC treated with curettage, cryotherapy and bone grafting treated in our institution between 2016 and 2022. Complications were recorded, as well as local recurrences. Patients’ post-operative functionality was assessed with the MSTS score. Results: Fourteen consecutive cases were included in our study. Their mean age at surgery was 13.5 years. The mean lesion size was 55 mm. The mean follow-up was 38 months. Two cases (11.8%) had local recurrences, which were successfully treated with further curettage. At their latest FU, 13 cases were continuously disease free (CDF), and one had no evidence of disease (NED). Only one case had a post-operative compilation (wound dehiscence). Patients’ mean post-operative MSTS score was 29.6. Conclusions: Pelvic ABCs are a challenge, even for the most experienced orthopedic surgeon. Our study suggests that the association of an accurate curettage, intraoperative cryotherapy and bone grafting can be a reliable and effective therapeutic option for large-sized ABCs of the pelvis.
Qualitative Methodology in Translational Health Research: Current Practices and Future Directions
Authors: Rana Kritika , Poudel Prakash , Chimoriya Ritesh
Published: October 2023

Translational health research is an interdisciplinary field aimed at bridging the gap between basic science studies, preventative studies, and clinical practice to improve health-related outcomes. Qualitative research methods provide a unique perspective on the emotional, social, cultural, and contextual factors that influence health and healthcare and thus are recognized as valuable tools for translational health research. This approach can be embedded within a mixed method design which complements the quantitative findings. This methodological paper aims to provide a comprehensive review of the fundamental concepts and methodologies used in qualitative research, emphasizing their utilization and significance in translational health research. Several approaches to qualitative research methodology are discussed in this review, including ethnography, phenomenology, grounded theory, case study, and action research. Theoretical frameworks such as the social-ecological model, intersectionality, and participatory action research are also examined to provide a structure for understanding and interpreting complex health issues. This methodological paper also reviews commonly used sampling techniques such as purposive, snowball, convenience, theoretical, and maximum variation sampling, along with data collection methods such as in-depth interviews, focus groups, observation, document analysis, and participatory methods. Moreover, data analysis techniques such as thematic analysis, grounded theory, content analysis, narrative analysis, and reflexive analysis, are discussed in the context of translational health. Overall, this review highlights the challenges and opportunities of using qualitative methods in current practice, while also discussing future directions and providing valuable guidance and insights to researchers interested in conducting qualitative research in translational health.
Potential Clinical Usefulness of Post-Valvular Contrast Densities to Determine the Severity of Aortic Valve Stenosis Using Computed Tomography
Authors: Racz Agnes Orsolya , Szabo Gabor Tamas , Papp Tamas , Csippa Benjamin , Gyurki Daniel , Kracsko Bertalan , Koszegi Zsolt , Kolozsvari Rudolf
Published: October 2023

Background: Different methods are established for the changes in aortic valve stenosis with cardiac computed tomography angiography (CCTA), but the effect of the grade of stenosis on contrast densities around the valve has not been investigated. Aims/methods: Using the information from flow dynamics in cases of increased velocity through narrowed lumen, the hypothesis was formed that flow changes can alter the contrast densities in stenotic post-valvular regions, and the density changes might correlate with the grade of stenosis. Forty patients with severe aortic stenosis and fifteen with a normal aortic valve were enrolled. With echocardiography, the peak/mean transvalvular gradients, peak transvalvular velocity, and aortic valve opening area were obtained. With CCTA, densities 4–5 mm above the aortic valve; at the junction of the left, right, and noncoronary cusp to the annulus; at the middle level of the left, right, and noncoronary sinuses of Valsalva in the center and the lateral points; at the sinotubular junction; and 4 cm from the sinotubular junction at the midline were measured. First, a comparison of the densities between the normal and stenotic valve was performed, and then possible correlations between echocardiography and CCTA values were investigated in the stenotic group. Results: In all CCTA regions, significantly lower-density values were detected among stenotic valve patients compared to the normal aortic valve population. Additionally, in both groups, higher densities were measured in the peri-jet regions than in the lateral ones. Furthermore, a good correlation was found between the aortic valve opening area and the densities in almost all perivalvular areas. With regard to the densities at the junction of the non-coronary leaflet to the fibrotic annulus and at the most lateral point of the right sinus of Valsalva, a high level of correlation was found between all echocardiography and CCTA parameters. Lastly, with receiver operating characteristic curve measurements, area under the curve values were between 0.857 and 0.930. Conclusion: Certain CCTA density values, especially 4–5mm above the valve opening, can serve as auxiliary information to echocardiography when the severity of aortic valve stenosis is unclear.
Influencer Engagement on Social Media: A Conceptual Model, the Development and Validation of a Measurement Scale
Authors: Levesque Nataly , Pons Frank
Published: October 2023

This research aims to conceptualize, develop, and validate a specific instrument for measuring the engagement of followers towards influencers on social media, and more specifically, in this first research, on Instagram. We surveyed (in-depth interviews, and questionnaires) 32 marketing experts and 1170 Instagram followers. Based on the applications of factor analysis and structural equation modelling, we determined 21 valid items. The scale assesses the cognitive, affective, and behavioral characteristics of follower’s engagement across five dimensions. The results provide insight into the interactive, personal, and social aspects of this type of virtual engagement. It is the first scale to measure this engagement in a multidimensional framework, which advances future research. Additionally, it will help managers identify the strongest dimensions of their influencers’ engagement and thus be able to adjust marketing communication strategies to foster multidimensional follower engagement and subsequent partnerships.
Transition Metal Borides for All-in-One Radiation Shielding
Authors: Avcıoğlu Celal , Avcıoğlu Suna
Published: October 2023

All-in-one radiation shielding is an emerging concept in developing new-generation radiation protection materials since various forms of ionizing radiation, such as neutrons and gamma rays, can occur simultaneously. In this study, we examine the ability of transition metal borides to attenuate both photon and particle radiation. Specifically, fourteen different transition metal borides (including inner transition metal borides) are selected for examination based on their thermodynamic stabilities, molecular weights, and neutron capture cross-sections of the elements they contain. Radiation shielding characteristics of the transition metal borides are computationally investigated using Phy-X/PSD, EpiXS and NGCal software. The gamma-ray shielding capabilities of the transition metal borides are evaluated in terms of the mass attenuation coefficient (μm), the linear attenuation coefficient (µ), the effective atomic number (Zeff), the half-value layer (HVL), the tenth-value layer (TVL), and the mean free path (MFP). The mass and linear attenuation factors are identified for thermal and fast neutrons at energies of 0.025 eV and 4 MeV, respectively. Moreover, the fast neutron removal cross-sections (∑R) of the transition metal borides are calculated to assess their neutron shielding abilities. The results revealed that borides of transition metals with a high atomic number, such as Re, W, and Ta, possess outstanding gamma shielding performance. At 4 MeV photon energy, the half-value layers of ReB2 and WB2 compounds were found as 1.38 cm and 1.43 cm, respectively. Most notably, these HVL values are lower than the HVL value of toxic Pb (1.45 cm at 4 MeV), which is one of the conventional radiation shielding materials. On the other hand, SmB6 and DyB6 demonstrated exceptional neutron attenuation for thermal and fast neutrons due to the high neutron capture cross-sections of Sm, Dy, and B. The outcomes of this study reveal that transition metal borides can be suitable candidates for shielding against mixed neutron and gamma radiation.
Investigation on Applying Biodegradable Material for Removal of Various Substances (Fluorides, Nitrates and Lead) from Water
Authors: Albrektienė-Plačakė Ramunė , Bazienė Kristina , Gargasas Justinas
Published: October 2023

Sapropel was used as a biodegradable material for water treatment. Sapropel is a sedimentary layer of a mix of organic and inorganic substances accumulated in the bottoms of lakes for thousands of years. It is a jelly-like homogeneous mass and has properties of sorption. Sapropel is used as a biosorbent and an environment-friendly fertiliser, and it is used in building materials and in the beauty industry as well. In water, there are abundant various solutes that may cause a risk to human health. Such substances include fluorides, nitrates and lead in different sources of water. The goal of this investigation is to explore and compare the efficiencies of removal of different pollutants (fluorides, nitrates and lead) from aqueous solutions upon using sapropel as a sorbent. In this research, various doses of sapropel (0.1, 0.5, 1, 5, 10, 20, 50, 100 and 200 g/L) and various mixing times (15, 30, 60, 90 and 120 min) were used for removal of fluorides, nitrates and lead from aqueous solutions. It was found that the maximum efficiency (up to 98.57%) of lead removal from aqueous solutions by sapropel was achieved when the minimum doses of it (0.1 and 0.5 g/L) were used. The most efficient removal of fluorides (64.67%) was achieved by using 200 g/L of sapropel and mixing for 120 min. However, sapropel does not adsorb nitrates from aqueous solutions.
Blast Effects on Hyperloop’s Cylindrical Thin-Shell Structures
Authors: Kaewunruen Sakdirat , Roxburgh Joseph , Remennikov Alex M.
Published: October 2023

Super-high-speed guided systems such as hyperloops and MagLev are highly at risk of cyber and physical threats from either natural or man-made hazards. This study thus adopts a nonlinear finite element method to investigate and analyse blast responses of a spatial thin-shell structure formed as an essential part of the Hyperloop tunnelling system. The thin-shell structure is a longitudinal cylindrical tube used in hyperloop rail concepts that will have the capability to carry passenger pods travelling at speeds in excess of 1000 km/h. A robust parametric study has been carried out on a thin-shell metallic cylinder in accordance with experimental results to validate the blast simulation modelling approach. In addition, case studies have been conducted to simulate the effects of varied charge loading (TNT equivalent) of 10 kg, 15 kg and 20 kg. Since the hyperloop system is in its development stages, potential design modifications to adjust the thickness of the thin-shell cylinder are also simulated. Our findings demonstrate that thicker walls of 30 mm yield almost negligible dynamic displacements with lower blast pressures. However, this modification can cause serious ramifications in terms of infrastructure costs. On this ground, venting ports for blast mitigation have been proposed to alter and alleviate blast effects on the tube deformations. The novel insights reveal that increased venting port sizes can significantly increase the impulse deformations of the hyperloop tube but are key in reducing blast pressures within the asset infrastructure. These findings will inform hyperloop engineers about potential design solutions to ensure safety and reliability of future hyperloop rail travels amid the risks and uncertainties of cyber and physical threats.
Transition from Bi- to Quadro-Stability in Models of Population Dynamics and Evolution
Authors: Frisman Efim , Kulakov Matvey
Published: October 2023

The article is devoted to a review of bistability and quadro-stability phenomena found in a certain class of mathematical models of population numbers and allele frequency dynamics. The purpose is to generalize the results of studying the transition from bi- to quadro-stability in such models. This transition explains the causes and mechanisms for the appearance and maintenance of significant differences in numbers and allele frequencies (genetic divergence) in neighboring sites within a homogeneous habitat or between adjacent generations. Using qualitative methods of differential equations and numerical analysis, we consider bifurcations that lead to bi- and quadro-stability in models of the following biological objects: a system of two coupled populations subject to natural selection; a system of two connected limited populations described by the Bazykin or Ricker model; a population with two age stages and density-dependent regulation. The bistability in these models is caused by the nonlinear growth of a local homogeneous population or the phase bistability of the 2-cycle in populations structured by space or age. We show that there is a series of similar bifurcations of equilibrium states or fixed or periodic points that precede quadro-stability (pitchfork, period-doubling, or saddle-node bifurcation).
Utilizing m-Polar Fuzzy Saturation Graphs for Optimized Allocation Problem Solutions
Authors: Alanazi Abdulaziz M. , Muhiuddin Ghulam , Alenazi Bashair M. , Mahapatra Tanmoy , Pal Madhumangal
Published: October 2023

It is well known that crisp graph theory is saturated. However, saturation in a fuzzy environment has only lately been created and extensively researched. It is necessary to consider m components for each node and edge in an m-polar fuzzy graph. Since there is only one component for this idea, we are unable to manage this kind of circumstance using the fuzzy model since we take into account m components for each node as well as edges. Again, since each edge or node only has two components, we are unable to apply a bipolar or intuitionistic fuzzy graph model. In contrast to other fuzzy models, mPFG models produce outcomes of fuzziness that are more effective. Additionally, we develop and analyze these kinds of mPFGs using examples and related theorems. Considering all those things together, we define saturation for a m-polar fuzzy graph (mPFG) with multiple membership values for both vertices and edges; thus, a novel approach is required. In this context, we present a novel method for defining saturation in mPFG involving m saturations for each element in the membership value array of a vertex. This explains α-saturation and β-saturation. We investigate intriguing properties such as α-vertex count and β-vertex count and establish upper bounds for particular instances of mPFGs. Using the concept of α-saturation and α-saturation, block and bridge of mPFG are characterized. To identify the α-saturation and β-saturation mPFGs, two algorithms are designed and, using these algorithms, the saturated mPFG is determined. The time complexity of these algorithms is O(|V|3), where |V| is the number of vertices of the given graph. In addition, we demonstrate a practical application where the concept of saturation in mPFG is applicable. In this application, an appropriate location is determined for the allocation of a facility point.
Robust Bi-Level Optimization for Maritime Emergency Materials Distribution in Uncertain Decision-Making Environments
Authors: Wang Cong , Peng Zhongxiu , Xu Wenqing
Published: October 2023

Maritime emergency materials distribution is a key aspect of maritime emergency responses. To effectively deal with the challenges brought by the uncertainty of the maritime transport environment, the multi-agent joint decision-making location-routing problem of maritime emergency materials distribution (MEMD-LRP) under an uncertain decision-making environment is studied. First, two robust bi-level optimization models of MEMD-LRP are constructed based on the effect of the uncertainty of the ship’s sailing time and demand of emergency materials at the accident point, respectively, on the premise of considering the rescue time window and priority of emergency materials distribution. Secondly, with the help of robust optimization theory and duality theory, the robust optimization models are transformed into robust equivalent models that are easy to solve. Finally, a hybrid algorithm based on the ant colony and tabu search (ACO-TS) algorithm solves multiple sets of numerical cases based on the case design of the Bohai Sea area, and analyzes the influence of uncertain parameters on the decision making of MEMD-LRP. The study of MEMD-LRP under uncertain decision-making environments using bi-level programming and robust optimization methods can help decision makers at different levels of the maritime emergency logistics system formulate emergency material reserve locations and emergency material distribution schemes that can effectively deal with the uncertainty in maritime emergencies.
Essential Components from Plant Source Oils: A Review on Extraction, Detection, Identification, and Quantification
Authors: Rahim Muhammad Abdul , Ayub Hudda , Sehrish Aqeela , Ambreen Saadia , Khan Faima Atta , Itrat Nizwa , Nazir Anum , Shoukat Aurbab , Shoukat Amna , Ejaz Afaf , Özogul Fatih , Bartkiene Elena , Rocha João Miguel
Published: October 2023

Oils derived from plant sources, mainly fixed oils from seeds and essential oil from other parts of the plant, are gaining interest as they are the rich source of beneficial compounds that possess potential applications in different industries due to their preventive and therapeutic actions. The essential oils are used in food, medicine, cosmetics, and agriculture industries as they possess antimicrobial, anticarcinogenic, anti-inflammatory and immunomodulatory properties. Plant based oils contain polyphenols, phytochemicals, and bioactive compounds which show high antioxidant activity. The extractions of these oils are a crucial step in terms of the yield and quality attributes of plant oils. This review paper outlines the different modern extraction techniques used for the extraction of different seed oils, including microwave-assisted extraction (MAE), pressurized liquid extraction (PLE), cold-pressed extraction (CPE), ultrasound-assisted extraction (UAE), supercritical-fluid extraction (SFE), enzyme-assisted extraction (EAE), and pulsed electric field-assisted extraction (PEF). For the identification and quantification of essential and bioactive compounds present in seed oils, different modern techniques—such as high-performance liquid chromatography (HPLC), gas chromatography–mass spectrometry (GC-MS), Fourier transform infrared spectroscopy (FTIR), gas chromatography–infrared spectroscopy (GC-IR), atomic fluorescence spectroscopy (AFS), and electron microscopy (EM)—are highlighted in this review along with the beneficial effects of these essential components in different in vivo and in vitro studies and in different applications. The primary goal of this research article is to pique the attention of researchers towards the different sources, potential uses and applications of oils in different industries.
In Situ Decoration of Bi2S3 Nanosheets on Zinc Oxide/Cellulose Acetate Composite Films for Photodegradation of Dyes under Visible Light Irradiation
Authors: Dan Yixiao , Xu Jialiang , Jian Jian , Meng Lingxi , Deng Pei , Yan Jiaqi , Yuan Zhengqiu , Zhang Yusheng , Zhou Hu
Published: October 2023

A novel Bi2S3-zinc oxide/cellulose acetate composite film was prepared through a blending-wet phase conversion and in situ precipitate method. The results revealed that the incorporation of Bi2S3 in the film increased the cavity density and uniformity, which provided additional space for the growth of active species and improved the interaction between dye pollutants and active sites. Zinc oxide acted as a mediator to facilitate the separation of electron–hole pairs effectively preventing their recombination, thus reducing the photo-corrosion of Bi2S3. As a result, the Bi2S3-ZnO/CA composite film exhibited favorable photocatalytic activity in the degradation of various dyes. Additionally, the composite film displayed effortless separation and recovery without the need for centrifugation or filtration, while maintaining its exceptional catalytic performance even after undergoing various processes.
Soot Erased: Catalysts and Their Mechanistic Chemistry
Authors: Zuhra Zareen , Li Shuo , Xie Guanqun , Wang Xiaoxia
Published: October 2023

Soot formation is an inevitable consequence of the combustion of carbonaceous fuels in environments rich in reducing agents. Efficient management of pollution in various contexts, such as industrial fires, vehicle engines, and similar applications, relies heavily on the subsequent oxidation of soot particles. Among the oxidizing agents employed for this purpose, oxygen, carbon dioxide, water vapor, and nitrogen dioxide have all demonstrated effectiveness. The scientific framework of this research can be elucidated through the following key aspects: (i) This review situates itself within the broader context of pollution management, emphasizing the importance of effective soot oxidation in reducing emissions and mitigating environmental impacts. (ii) The central research question of this study pertains to the identification and evaluation of catalysts for soot oxidation, with a specific emphasis on ceria-based catalysts. The formulation of this research question arises from the need to enhance our understanding of catalytic mechanisms and their application in environmental remediation. This question serves as the guiding principle that directs the research methodology. (iii) This review seeks to investigate the catalytic mechanisms involved in soot oxidation. (iv) This review highlights the efficacy of ceria-based catalysts as well as other types of catalysts in soot oxidation and elucidate the underlying mechanistic strategies. The significance of these findings is discussed in the context of pollution management and environmental sustainability. This study contributes to the advancement of knowledge in the field of catalysis and provides valuable insights for the development of effective strategies to combat air pollution, ultimately promoting a cleaner and healthier environment.
Solvent-Induced Lag Phase during the Formation of Lysozyme Amyloid Fibrils Triggered by Sodium Dodecyl Sulfate: Biophysical Experimental and In Silico Study of Solvent Effects
Authors: Zazeri Gabriel , Povinelli Ana Paula Ribeiro , Pavan Nathália Mariana , Jones Alan M. , Ximenes Valdecir Farias
Published: October 2023

Amyloid aggregates arise from either the partial or complete loss of the native protein structure or the inability of proteins to attain their native conformation. These aggregates have been linked to several diseases, including Alzheimer’s, Parkinson’s, and lysozyme amyloidosis. A comprehensive dataset was recently reported, demonstrating the critical role of the protein’s surrounding environment in amyloid formation. In this study, we investigated the formation of lysozyme amyloid fibrils induced by sodium dodecyl sulfate (SDS) and the effect of solvents in the medium. Experimental data obtained through fluorescence spectroscopy revealed a notable lag phase in amyloid formation when acetone solution was present. This finding suggested that the presence of acetone in the reaction medium created an unfavorable microenvironment for amyloid fibril formation and impeded the organization of the denatured protein into the fibril form. The in silico data provided insights into the molecular mechanism of the interaction between acetone molecules and the lysozyme protofibril, once acetone presented the best experimental results. It was observed that the lysozyme protofibril became highly unstable in the presence of acetone, leading to the complete loss of its β-sheet conformation and resulting in an open structure. Furthermore, the solvation layer of the protofibril in acetone solution was significantly reduced compared to that in other solvents, resulting in fewer hydrogen bonds. Consequently, the presence of acetone facilitated the exposure of the hydrophobic portion of the protofibril, precluding the amyloid fibril formation. In summary, our study underscores the pivotal role the surrounding environment plays in influencing amyloid formation.
Encapsulation and Biological Activity of Hesperetin Derivatives with HP-β-CD
Authors: Sykuła Anna , Bodzioch Agnieszka , Nowak Adriana , Maniukiewicz Waldemar , Ścieszka Sylwia , Piekarska-Radzik Lidia , Klewicka Elżbieta , Batory Damian , Łodyga-Chruścińska Elżbieta
Published: October 2023

The encapsulation of insoluble compounds can help improve their solubility and activity. The effects of cyclodextrin encapsulation on hesperetin’s derivatives (HHSB, HIN, and HTSC) and the physicochemical properties of the formed complexes were determined using various analytical techniques. The antioxidant (DPPH•, ABTS•+ scavenging, and Fe2+-chelating ability), cytotoxic, and antibacterial activities were also investigated. The inclusion systems were prepared using mechanical and co-evaporation methods using a molar ratio compound: HP-β-CD = 1:1. The identification of solid systems confirmed the formation of two inclusion complexes at hesperetin (CV) and HHSB (mech). The identification of systems of hesperetin and its derivatives with HP-β-CD in solutions at pHs 3.6, 6.5, and 8.5 and at various temperatures (25, 37 and 60 °C) confirmed the effect of cyclodextrin on their solubility. In the DPPH• and ABTS•+ assay, pure compounds were characterized by higher antioxidant activity than the complexes. In the FRAP study, all hesperetin and HHSB complexes and HTSC-HP-β-CD (mech) were characterized by higher values of antioxidant activity than pure compounds. The results obtained from cytotoxic activity tests show that for most of the systems tested, cytotoxicity increased with the concentration of the chemical, with the exception of HP-β-CD. All systems inhibited Escherichia coli and Staphylococcus aureus.
First-Row Transition Metal Complexes Incorporating the 2-(2′-pyridyl)quinoxaline Ligand (pqx), as Potent Inflammatory Mediators: Cytotoxic Properties and Biological Activities against the Platelet-Activating Factor (PAF) and Thrombin
Authors: Margariti Antigoni , Papakonstantinou Vasiliki D. , Stamatakis George M. , Demopoulos Constantinos A. , Machalia Christina , Emmanouilidou Evangelia , Schnakenburg Gregor , Nika Maria-Christina , Thomaidis Nikolaos S. , Philippopoulos Athanassios I.
Published: October 2023

Inflammatory mediators constitute a recently coined term in the field of metal-based complexes with antiplatelet activities. Our strategy targets Platelet-Activating Factor (PAF) and its receptor, which is the most potent lipid mediator of inflammation. Thus, the antiplatelet (anti-PAF) potency of any substance could be exerted by inhibiting the PAF-induced aggregation in washed rabbit platelets (WRPs), which internationally is a well-accepted methodology. Herein, a series of mononuclear (mer-[Cr(pqx)Cl3(H2O]) (1), [Co(pqx)Cl2(DMF)] (2) (DMF = N,N′-dimethyl formamide), [Cu(pqx)Cl2(DMSO)] (3) (DMSO = dimethyl sulfoxide), [Zn(pqx)Cl2] (4)) and dinuclear complexes ([Mn(pqx)(H2O)2Cl2]2 (5), [Fe(pqx)Cl2]2 (6) and [Ni(pqx)Cl2]2 (7)) incorporating the 2-(2′-pyridyl)quinoxaline ligand (pqx), were biologically evaluated as inhibitors of the PAF- and thrombin-induced aggregation in washed rabbit platelets (WRPs). The molecular structure of the five-co-ordinate analog (3) has been elucidated by single-crystal X-ray diffraction revealing a trigonal bipyramidal geometry. All complexes are potent inhibitors of the PAF-induced aggregation in WRPs in the micromolar range. Complex (6) displayed a remarkable in vitro dual inhibition against PAF and thrombin, with IC50 values of 1.79 μM and 0.46 μM, respectively. Within the series, complex (5) was less effective (IC50 = 39 μM) while complex (1) was almost 12-fold more potent against PAF, as opposed to thrombin-induced aggregation. The biological behavior of complexes 1, 6 and 7 on PAF’s basic metabolic enzymatic pathways reveals that they affect key biosynthetic and catabolic enzymes of PAF underlying the anti-inflammatory properties of the relevant complexes. The in vitro cytotoxic activities of all complexes in HEK293T (human embryonic kidney cells) and HeLa cells (cervical cancer cells) are described via the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. The results reveal that complex 3 is the most potent within the series.
Effects of RF Magnetron Sputtering Power on the Mechanical Behavior of Zr-Cu-Based Metallic Glass Thin Films
Authors: Nguyen Tra Anh Khoa , Dang Nhat Minh , Lin Chi-Hang , Lee Meng-Chieh , Wang Zhao-Ying , Tsai Yao-Chuan , Lin Ming-Tzer
Published: October 2023

Zirconium-based metallic glass films are promising materials for nanoelectronic and biomedical applications, but their mechanical behavior under different conditions is not well understood. This study investigates the effects of radio frequency (RF) power and test temperature on the nanostructure, morphology, and creep behavior of Zr55Cu30Al10Ni5 metallic glass films prepared by RF magnetron sputtering. The films were characterized by X-ray diffraction and microscopy, and their mechanical properties were measured by a bulge test system. The results show that the films were amorphous and exhibited a transition from noncolumnar to columnar morphology as the RF power increased from 75 W to 125 W. The columnar morphology reduced the creep resistance, Young’s modulus, residual stress, and hardness of the films. The creep behavior of the films was also influenced by the test temperature, with higher temperature leading to higher creep strain and lower creep stress. The findings of this study provide insights into the optimization of the sputtering parameters and the design of zirconium-based metallic glass films for various applications.