bluuebunny/crossref_metadata_2025 huggingface dataset:
Wide Transition-State Ensemble as Key Component for Enzyme Catalysis
Authors: Jara Gabriel Ernesto , Pontiggia Francesco , Otten Renee , Agafonov Roman V , Martí Marcelo A , Kern Dorothee
Published: January 2025

Transition-state theory has provided the theoretical framework to explain the enormous rate accelerations of chemical reactions by enzymes. Given that proteins display large ensembles of conformations, unique transition states would pose a huge entropic bottleneck for enzyme catalysis. To shed light on this question, we studied the nature of the enzymatic transition state for the phosphoryl-transfer step in adenylate kinase by quantum-mechanics/molecular-mechanics calculations. We find a structurally wide set of energetically equivalent configurations that lie along the reaction coordinate and hence a broad transition-state ensemble (TSE). A conformationally delocalized ensemble, including asymmetric transition states, is rooted in the macroscopic nature of the enzyme. The computational results are buttressed by enzyme kinetics experiments that confirm the decrease of the entropy of activation predicted from such wide TSE. Transition-state ensembles as a key for efficient enzyme catalysis further boosts a unifying concept for protein folding and conformational transitions underlying protein function.
Oxidized low-density lipoprotein potentiates angiotensin II-induced Gq activation through the AT1-LOX1 receptor complex: Implications for renal dysfunction
Authors: Ihara Jittoku , Huang Yibin , Takami Yoichi , Nozato Yoichi , Takahashi Toshimasa , Kakino Akemi , Wang Cheng , Wang Ziwei , Guo Yu , Liu Weidong , Yin Nanxiang , Ohara Ryoichi , Fujimoto Taku , Yoshida Shino , Hongyo Kazuhiro , Koriyama Hiroshi , Akasaka Hiroshi , Takeshita Hikari , Sakai Shinsuke , Inoue Kazunori , Isaka Yoshitaka , Rakugi Hiromi , Sawamura Tatsuya , Yamamoto Koichi
Published: January 2025

Chronic kidney disease (CKD) and atherosclerotic heart disease, frequently associated with dyslipidemia and hypertension, represent significant health concerns. We investigated the interplay among these conditions, focusing on the role of oxidized low-density lipoprotein (oxLDL) and angiotensin II (Ang II) in renal injury via G protein αq subunit (Gq) signaling. We hypothesized that oxLDL enhances Ang II-induced Gq signaling via the AT1 (Ang II type 1 receptor)-LOX1 (lectin-like oxLDL receptor) complex. Based on CHO and renal cell model experiments, oxLDL alone did not activate Gq signaling. However, when combined with Ang II, it significantly potentiated Gq-mediated inositol phosphate 1 production and calcium influx in cells expressing both LOX-1 and AT1 but not in AT1-expressing cells. This suggests a critical synergistic interaction between oxLDL and Ang II in the AT1-LOX1 complex. Conformational studies using AT1 biosensors have indicated a unique receptor conformational change due to the oxLDL-Ang II combination. In vivo, wild-type mice fed a high-fat diet with Ang II infusion presented exacerbated renal dysfunction, whereas LOX-1 knockout mice did not, underscoring the pathophysiological relevance of the AT1-LOX1 interaction in renal damage. These findings highlight a novel mechanism of renal dysfunction in CKD driven by dyslipidemia and hypertension and suggest the therapeutic potential of AT1-LOX1 receptor complex in patients with these comorbidities.
Analysis of Role of Haematological Parameters in Diagnosis of Grampositive and Gram-negative Urinary Tract Infection: A Case-control Study
Authors: Srinivasan Sudha , Thajudeen Ayeesha Sithika , Chandrasekaran Kundhavai , Raghavan Vijayashree , Roshini D
Published: January 2025

Introduction: Urinary Tract Infections (UTIs) are a prevalent global health issue, primarily caused by bacterial infections. Early diagnosis and intervention are critical to preventing complications like pyelonephritis and mitigating the risk of recurrent infections that can lead to permanent scarring.

Aim: To investigate the haematological parameters in patients with confirmed UTIs, comparing them with non UTI counterparts and discerning variations in haematological parameters between UTIs caused by gram-positive and gram-negative bacterial organisms.

Materials and Methods: This prospective case-control study was conducted at Chettinad Hospital and Research Institute (tertiary care centre), Chengalpattu, Tamil Nadu, India between January 2023 and July 2023, included 105 culture-positive UTI cases and 105 age- and gender-matched culture-negative controls. Cases included patients over 12 years of age with confirmed UTIs, while exclusions for both groups included pregnancy, individuals under 12 and those with haematological disorders. Controls were also excluded if they had diabetes or chronic kidney disease. Urine cultures on blood and MacConkey agar identified pathogens such as E. coli, Pseudomonas, Klebsiella, Enterobacter, Proteus and Citrobacter. Grampositive isolates included Enterococci species, Staphylococcus aureus and Staphylococcus saprophyticus. Haematological parameters such as Haemoglobin (Hb), White Blood Cell Count (WBC), platelet count, Mean Platelet Volume (MPV), Red Cell Distribution Width (RDW), Platelet Distribution Width (PDW) and Plateletcrit (PCT) were analysed using an automated haematology analyser. Statistical analysis was performed using Statistical Package for Social Sciences (SPSS) software version 22.0 with significance set at p-value <0.05.

Results: The UTI patients exhibited lower Hb and higher WBC, platelet count, MPV, RDW, PDW and PCT compared to controls. Gram-positive UTI infections showed higher WBC count, platelet counts, RDW, PDW and PCT, but lower MPV compared to gram-negative UTI infections. E. coli and Enterococcus were the predominant gram-negative and gram-positive pathogens, respectively, reflecting distinct haematological profiles. These results highlight distinct immune and haematological profiles in UTI patients, depending on the infecting organism.

Conclusion: The UTI patients exhibited lower Hb and higher WBC, platelet count, MPV, RDW, PDW and PCT compared to controls. Gram-positive UTI infections showed higher WBC count, platelet counts, RDW, PDW and PCT, but lower MPV compared to gram-negative UTI infections. E. coli and Enterococcus were the predominant gram-negative and gram-positive pathogens, respectively, reflecting distinct haematological profiles. These results highlight distinct immune and haematological profiles in UTI patients, depending on the infecting organism.
Structured Self-Assessment Exercises as a Substitute for Small-Group Tutorial Teaching in Diagnostic Imaging Student Preferences and Effects on Examination Performance
Authors: Peterson Cynthia
Published: January 2025

Research into chiropractic and medical education supports the concept of teaching in a problem-solving approach, simulating the realities of clinical practice. Along with this approach, small-group tutorials have more commonly become the method of delivery of course material, focusing on the learner rather than the teacher. However, offering frequent small-group tutorial sessions is very labor intensive for faculty. The purpose of this study was to determine whether or not structured self-assessment exercises could substitute for some small-group tutorial time without jeopardizing the quality of the students’ education. At the end of the 1999–2000 academic year, a short questionnaire was administered to all 4th-year students to assess their attitudes and opinions about the value of each of the teaching/learning approaches utilized in radiology using a 5-point Likert scale. Final examination marks were compared to the previous cohort of students to determine changes in performance/radiological ability. The examination marks from the 4th-year cohort were compared to their own radiological examination marks from the previous year. The results indicate that students strongly prefer the small-group face-to-face tutorials with the faculty members but rated the self-assessment exercises as ‘‘above average’’ in usefulness. The interactive lecture was also rated as ‘‘very useful.’’ There was no meaningful or significant change in the final examination performances between the current 4th-year cohort and the previous group of students. For the first time in 10 years, no student failed the final film reading examination. It was concluded that the structured self-assessment exercises can serve as a very valuable learning tool and significantly reduce tutor contact time in an overburdened time-table but do not have a negative impact on students’ diagnostic abilities. A combination of small-group tutorials and structured self-assessment exercises is the preferred approach, balancing the wishes of the students with the needs of the faculty as well as providing a varied educational learning experience. (The Journal of Chiropractic Education 15(2): 61–68, 2001)
Diversity in Chiropractic Technique: A Proposed Solution to the Obstacles Associated with Teaching and Evaluating Technique in the Academic and Clinical Settings of a Chiropractic College
Authors: Petty Steven , McCoy Matthew , Jezequel Joanne
Published: January 2025

There has been no formal standardization in the teaching of subluxation-based chiropractic technique and analysis within chiropractic institutions. A solution is offered via a functional model for standardization and faculty certification in chiropractic technique. A proposal was created by the Clinical Faculty and the Department of Technique & Analysis to standardize the teaching of technique and to certify faculty members in various chiropractic techniques. An evolving process developed which resulted in a standardized knowledge base of technique as taught by faculty in the clinics and the Department of Technique & Analysis. There was an increase in knowledge regarding technique protocols, as well as an increase in communication between administration, clinic, and academic faculty. A majority of the faculty members received instruction about and were certified in at least two techniques. The standardization and certification process evolved from a fairly rigid model to one that allowed for more flexibility between the various groups and individuals involved. The process should be subjected to necessary modifications in order to strengthen the process and its outcome.
Community Analysis of Plant Parasitic Nematodes in the Rhizosphere of Vegetable Crops in Jorhat, Assam
Authors: Chatterjee Arkadeb , Das Debanand
Published: January 2025

The study aimed to analyze the community composition, abundance, and distribution of plant-parasitic nematodes in the rhizosphere of vegetable crops in the Jorhat district of Assam, with a focus on identifying dominant nematode species and assessing their impact on crop health. A comprehensive approach employing nematode sampling, identification, and statistical analysis to evaluate nematode population. The study was conducted in five locations (Alengmora, Teok, Jorhat, Titabar, and Mariani) of the Jorhat district, Assam, India, from 2021 to 2022. A total of 146 composite soil and root samples were collected from the rhizosphere of 39 vegetable crops. Nematodes were extracted and morphologically identified nematode species were classified into eight genera, and community metrics such as absolute frequency, relative frequency, absolute density, relative density, prominence value, and plant-parasitic index were calculated following Norton's methodology. The index of similarity was used to compare nematode communities across locations. Eight nematode species from eight genera were recorded. Meloidogyne incognita was the most dominant species, exhibiting the highest mean absolute density (5356.01) and relative density (44.51%). It also had the highest prominence value (247.25). Alengmora, Teok, and Jorhat locations harbored all eight nematode species, while Titabar and Mariani had six each. The index of similarity revealed considerable overlap in nematode species among the locations. The study highlights the dominance of M. incognita in the Jorhat district, emphasizing the need for targeted nematode management strategies. The findings offer critical insights into nematode ecology and underscore the importance of site-specific interventions to reduce crop losses in vegetable production systems.
Study of Mechanical Vibration Analysis and Modelling Using Engineering Programs
Authors: SHAMSALDEEN FAISAL
Published: January 2025

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Enhancing the Mechanical and Thermal Properties of Pine Wood Using Nanocomposite Reinforcement for Advanced Application
Authors: Kumari Pooja , Singh Pooja , Jadoun R.S.
Published: January 2025

Wood has been a necessity of society as the source of energy production, buildings, and furniture since the
inception of human civilizations. To enhance the performance of furniture and building components for
application under humid environments, wood has been subjected to modification through reinforcing the
polymeric fillers over the decades. The present investigation deals with modification in mechanical and thermal
properties of pine wood (PW). Modification of the properties of WPC over untreated wood was evaluated in terms
of FTIR and simultaneous differential thermogravimetry-thermogravimetric-differential thermal analysis (DTGTG-DTA) in air. The study concludes that incorporating nanomaterials into pine wood significantly enhances its
mechanical strength and thermal stability, making it more durable and suitable for demanding environments. FTIR
analysis confirms adequate bonding between nanomaterials and wood, while TGA results demonstrate improved
resistance to thermal degradation, with slower decomposition and reduced mass loss at high temperatures.
Additionally, AIBN nanofluid enables complete thermal degradation, leaving minimal residue and making the
modified wood suitable for applications requiring full combustion or breakdown. These findings highlight the potential of nanomaterial-treated wood as a high-performance material for construction and other applications in humid or thermally intense environments.
Skin Disease Detection System Based On Convolutional Neural Network
Authors: Khan Shahid , Khan Zeeshan , Shah Ayaan , Belwalkar Shravani , Narkhede Prof. Sachin
Published: January 2025

Skin diseases present significant challenges in clinical diagnosis due to their diverse presentations and
overlapping symptoms. This study explores innovative approaches for the detection of skin diseases using
advanced imaging techniques and machine learning algorithms. By analyzing dermoscopic images and clinical
data, we developed a model that enhances diagnostic accuracy and reduces reliance on expert evaluation. Our
methodology incorporates preprocessing steps, feature extraction, and classification, demonstrating promising
results in identifying conditions such as melanoma, eczema, and psoriasis. The findings suggest that automated
skin disease detection can improve early diagnosis, facilitate timely treatment, and ultimately enhance patient
outcomes. This research underscores the potential of technology in dermatology, paving the way for future
applications in telemedicine and public health.
This study investigates the use of advanced imaging techniques and machine learning for the detection of skin
diseases. By analyzing dermoscopic images, we developed a model that improves diagnostic accuracy for
conditions like melanoma, melanocytic nevus, and ringworm. Our results indicate that automated detection can enhance early diagnosis and treatment, highlighting the potential of technology to transform dermatological care and improve patient outcome
Fearing the Black Body. The Racial History of Fatphobia. Libro de Sabrina Strings
Authors: Mitjans Alayón Tito
Published: July 2023

Escuché por primera vez sobre este libro en un grupo de Whatsapp, donde varias activistas, intelectuales y académicos intercambiamos ideas e investigaciones sobre cómo se evidencia la gordofobia en México. En un inicio esperaba un libro que hablase sobre los procesos de resistencia racial generizada de las personas negras que responden a la gordofobia como sistema de opresión tanto estructural como personal. Luego pensé que se centraría en las formas de opresión racial gordofóbica hacia los cuerpos negros, una explicación histórica. Sin embargo, el trabajo de la autora consistió en identificar el tratamiento que le ha dado la supremacía blanca a la gordura, incorporando un dispositivo de distinción corporal basado en los cuerpos delgados como ejes de naturalización del peso humano, como parte de los ejes estructurales que sostienen a la blanquitud.
ANALISIS PENERAPAN PERNYATAAN STANDAR AKUNTANSI PEMERINTAHAN (PSAP) NO 13 TAHUN 2015 PADA PENYAJIAN LAPORAN KEUANGAN UNIT PELAYANAN TEKNIS DAERAH (UPTD) PUSKESMAS BAJULMATI DI KABUPATEN BANYUWANGI
Authors: Wijiyono Ilma Faizah , Sari Nurshadrina Kartika , Ningsih Wiwik Fitria
Published: July 2023

This research was conducted to analyze the application of the Statement of Government Accounting Standards Number 13 of 2015 to the Presentation of Public Health Center Financial Reports as a form of Public Service Agency. This research uses a qualitative method that is descriptive with a case study approach. This study uses in-depth interviews with each informant. The results showed that the Bajulmati Health Center had not implemented PSAP No.13 of 2015 properly and correctly. In its implementation, the presentation of the financial reports of the Bajulmati Health Center uses Banyuwangi Regent Regulation No. 40 of 2018, Banyuwangi Regency Regional Regulation No. 17 of 2107, and Regulation of the Minister of Health of the Republic of Indonesia No. 6 of 2022 in accordance with the directions of the Health Service.
Assessment of carbon footprint performance by electric power enterprises in China
Authors: Yuan Peng , Zhang Yinya , Li Feng , Chen Shuangyin
Published: July 2023

Carbon neutrality is transitioning from a global consensus to global action. The power industry must urgently address carbon reduction and establish an effective evaluation system. However, current standard systems and literature studies both domestically and internationally reveal significant issues with the scientific, systematic, and operational aspects of carbon performance index systems. Therefore, this paper proposes the development of a carbon performance evaluation system for electric power enterprises, comprising of two subsystems: carbon management and carbon reduction. The evaluation system takes into full consideration the transmission and distribution characteristics of power grid companies, and conducts an empirical analysis on a regional power grid in China, including four provincial power grid companies A, B, C, and D. The findings indicate that the regional Power Grid has been committed to low-carbon initiatives for an extended period of time, with a greater emphasis on carbon reduction performance rather than carbon management performance between 2012 and 2021. To further enhance the potential for carbon reduction, it is imperative to prioritize carbon management in subsequent phases.
Analisis Kesalahan Siswa Dengan Tipe Berpikir Semikonseptual Berdasarkan Teori Nolthing
Authors: Suryaningrum Christine Wulandari , Iftha Frahnadya Ulul , Khotimah Galatea Chusnul
Published: July 2023

The purpose of this research is to describe students’ mistakes with semi-conceptual thinking types in solving mathematical problems in rectangular material. This type of research uses descriptive qualitative. Data collection techniques used written tests and semi-structured interviews. Subjects in class VIIE SMPN 7 Jember. Data analysis techniques use 3 ways, namely data reduction, data presentation, and drawing conclusions. The data validity technique uses the triangulation method. The results of this study are that many students make the same mistake due to a lack of reasoning ability to re-describe the information contained in the problem, and a lack of understanding of the concept so that dominant students just memorize concepts or formulas but cannot apply them to solve questions and do not check back answers to get answers. Correct result.
Keywords: students’ error, semi-conceptual thinking type, Nolthing theory
Information System for Predicting the Technical Condition of Electrical Equipment Devices
Authors: Ermakova D. A. , Fateev V. A.
Published: July 2023

The information system for predicting the technical condition of electrical equipment devices was described, which allows to analyze the data obtained and predict the residual life at the output in the form of regulatory documents. A new database using the open-source relational database management system MySQL (hereinafter – RDBMS MySQL) was designed. An analysis of the subject area and an analysis of the operation of electrical equipment devices was carried out. The developed information system allows to analyze the data obtained and predict the residual life in the form of regulatory documents.
Perspectives for the Conservation of Rare Species of the Fabaceae Family of the Flora of the Republic of Bashkortostan Ex Situ
Authors: Maslova Natalya , Elizaryeva Olga
Published: July 2023

The article presents the results of the primary introduction experience of rare species of the Fabaceae family of the flora of the Republic of Bashkortostan (the RB), included in the Red Data Book of the Russian Federation (2008). The study of these species was carried out in the Botanical Garden in Ufa. Under cultivation conditions, 5 rare species of the Fabaceae family were tested: еndemic of the Middle and Southern Urals Astragalus clerceanus Iljin et Krasch., Hedysarum grandiflorum Pall., Volga-South Ural endemic Hedysarum razoumovianum Fisch. et Helm, еndemic of the European part of Russia Medicago cancellata Bieb., еndemic of the Middle Volga and Trans-Volga regions Oxytropis hippolyti Boriss. These species are included in the Red Data Book of the RB (2021). According to a comprehensive introduction assessment under the primary introduction O. hippolyti is a very promising species, A. clerceanus and M. cancellata – promising species, H. grandiflorum and H. razoumovianum – unpromising species.
DARI SUFISTIK KE POP RELIGI: SEJARAH TRANSFORMASI MUSIK DALAM PERADABAN ISLAM
Authors: Pratama Fikri Surya
Published: July 2023

Musik dalam sejarah perkembangan peradaban Islam memiliki ragam legalitasnya, baik pelarangan oleh kaum Islam ortodoks, atau diperbolehkan oleh kaum sufi dan ulama lain selama tak ada unsur kemaksiatan. Perbedaan sudut pandang ini mengindikasikan besarnya peran seni musik dalam perkembangan peradaban Islam, sehingga perlu adanya pengawasan ketat atas musik dari masa peradaban Islam klasik hingga kontemporer. Tulisan ini bertujuan untuk menjelaskan transformasi perkembangan musik dalam sejarah peradaban Islam. Metode penelitian yang digunakan adalah metode penelitian sejarah dengan tahapannya: 1) Heuristik, sumber data penelitian dikumpulkan lewat studi pustaka; 2) Kritik Sumber, menyeleksi kevaliditas sumber data penelitian; 3) Interpretasi atau tahap analisis; 4) Historiografi. Hasil penelitian menunjukkan pada masa klasik hingga abad pertengahan peradaban Islam, musik identik dengan musif sufistik yang diperuntukkan sebagai media mendekatkan diri pada Tuhan. Praktik ini juga menghasilkan snei musik seperti nasyid dan qasidah. Eksistensi musik sufistik tergeser seiring modernisasi dan pengaruh budaya musik populer dari Barat. Pada umumnya pelaku musik pop religi identik dengan profesi ketimbang sebagai pihak yang menjadikan musik sebagai sarana meningkatkan gairah spiritual kepada Tuhan. Terdapat pergeseran posisi musik, dahulu sebagai wadah mencari kepuasan bathin dalam konteks religius, sekarang cenderung menjadi wadah konsumerisme yang kental ketimbang nilai religius dalam bermusik.
Развитие права на доступ к официальной информации в современном обществе
Authors: Кузнецов А.А. , Ворсова М.А.
Published: July 2023

В статье развитие права на доступ к официальной информации в современном обществе, рассмотрен теоретический аспект зарождения постиндустриального общества как предпосылки развития права на доступ к официальной информации. Произведен анализ развития права на доступ к официальной информации в Российской Федерации, а также в зарубежных странах. Указана мировая тенденция развития права на доступ к официальной информации посредством глобальной сети «Интернет». Приведена судебная практика и рассмотрены основные нормативно-правовые акты, касающиеся развития права на доступ к официальной информации.
Determination of solubility of cobalt in singlecrystal silicon method neutron activation
Authors: Tashmetov M. Yu.  , Makhkamov Sh .  , Tillaev T. S.  , Erdonov M. N.  , Kholmedov H. M.
Published: July 2023

The possibility of instrumental neutron activation analysis is revealed for determining the solubility of cobalt in single-crystal silicon. It was shown that in n-Si in the diffusion temperature range of 1000-1250oC the total solubility of the 60Co impurity varies within the concentration range of 2.8·1014-9·1015 cm-3, and the electrically active concentration grows from 1013 to 3·1014 cm-3. In order to reduce the error in determining the concentration of 1013 in doped Si samples, it is suggested to use the parent stable isotope rather than the daughter cobalt radionuclide. Keywords: monocrystalline silicon, cobalt impurity, diffusion, neutron activation analysis, solubility, irradiation, radionuclide, concentration.
Characterisation of antibody dependent cellular phagocytosis in patients infected with Hepatitis C virus with different clinical outcomes
Authors: Adhikari Anurag , Abayasingam Arunasingam , A Nicholas Brasher , Kim Ha Na , Lord Megan , Agapiou David , Maher Lisa , Rodrigo Chaturaka , Lloyd Andrew , Bull Rowena , Tedla Nicodemus
Published: July 2023

Early neutralising antibodies against Hepatitis C virus (HCV) and CD8+T
cell effector responses can lead to viral clearance. However, these
functions alone are not sufficient to protect patients against HCV
infection, thus yet undefined additional anti-viral immune mechanisms
are required. In recent years, Fc-receptor-dependent antibody effector
functions particularly, antibody-dependent cellular phagocytosis (ADCP)
was shown to offer immune protection against several RNA viruses.
However, its development, and clinical role in patients with HCV
infection remain unknown. In this study, we found that patients with
chronic GT1a or GT3a HCV infection had significantly higher
concentrations of anti-envelop 2 (E2) antibodies, predominantly IgG1
subclass, than patients that cleared the viruses while the latter had
antibodies with higher affinities. 97% of the patients with HCV had
measurable ADCP of whom patients with chronic disease showed
significantly higher ADCP than those who naturally cleared the virus.
Epitope mapping studies showed that patients with antibodies that target
antigenic domains on the HCV E2 protein that are known to associate with
neutralisation function also strongly associated with ADCP, suggesting
antibodies with overlapping/dual functions. Correlation studies showed
that ADCP significantly correlated with plasma anti-E2 antibody levels
and neutralisation function regardless of clinical outcome and genotype
of infecting virus while a significant correlation between ADCP and
affinity was only evident in patients that cleared the virus. These
results suggest ADCP was mostly driven by antibody titre in patients
with chronic disease while maintained in clearers due the quality
(affinity) of their anti-E2 antibodies despite having lower antibody
titres.
Current state of technical support of electronic justice in Ukraine
Authors: Kuzmenko O.V. , Sklyarenko G.V.
Published: July 2023

The article states that the system of electronic justice (justice) consists of elements that should be conventionally divided into three groups: 1) those that ensure the interaction of the court and participants in the judicial process (electronic court), that is, aimed directly at the implementation of justice and related processes with him (submitting a statement of claim, appeal, cassation complaint in electronic form, tracking the progress of the case on the Internet, sending court summonses, notifications by means of electronic communication, participating in the consideration of the case via video conference, access to court decisions in the Unified State register of court decisions, etc.); 2) those that ensure the interaction of courts with each other, as well as courts with other public administration bodies (electronic document circulation system, access to state registers, obtaining and verifying the validity of electronic evidence, etc.); 3) those that ensure the organization of internal management processes (electronic personnel management system, electronic court statistics system, electronic archives, electronic court library, etc.)In addition, it was established that electronic justice, as the basis of the informatization of the judicial system, currently not only provides an effective mechanism for citizens to protect their rights, but is also a key to the development of the information society. Its tools make it possible to make certain procedural and judicial actions virtual thanks to the use of information and telecommunication technologies. At the same time, the most successful result of electronic justice in Ukraine is providing access to court decisions in electronic form.It was concluded that the current situation, when almost all courtrooms in most courts of Ukraine are equipped with modern technology, which allows not only to conduct an audio recording of the meeting, but also to conduct it online or simply quickly and fully prepare a court decision in electronic form or provide all the necessary information to the parties to the process, is a new responsible stage in the development of justice. In addition, these opportunities become of great value in the conditions of martial law and in connection with the aggravation of the problem of court staffing. At the moment, unfortunately, the jurisdiction of many courts located in the temporarily occupied territories must be transferred to other courts, and almost every day the Supreme Council of Justice dismisses judges in connection with their resignations, which leads to an increase in the workload.
GURU DALAM DIMENSI PEMBELAJARAN
Authors: . Suraga
Published: July 2023

The presence of a teacher in the learning dimension is like a lantern for students. teachers as agents of renewal, teachers can be role models for students and the surrounding environment wherever they are, especially in learning, teachers can also teach many things to students from not knowing to knowing so that it is useful for the nation and state. So it is important for us to understand the position of the teacher in learning. If the teacher, students are at least able to learn knowledge and strengthen attitudes or morals. This, in line with the formation of noble morals, is a goal that should be prioritized in education, regardless of the material being taught. Therefore, every teacher is required to be able to explain the spirit or ethical values contained in any material taught, especially through attitudes and exemplary, thus, students or learners are not only given concepts that are purely scientific in nature, but also obtain a mirror and inculcate ethical values in it
PENGEMBANGAN POTENSI PESERTA DIDIK: PERSPEKTIF DOMAIN PENDIDIKAN BENJAMIN S. BLOOM
Authors: Jannah Sitti Riadil
Published: July 2023

The figure of Benjamin S. Bloom is an educational psychologist who has inspired a lot of education with a set of axiomatic frameworks that underlie it. The educational domain which is built on the cognitive, psychomotor, and affective domains has become a major contribution in developing the potential of students. These three domains must be applied in the educational process as an inseparable unit. In this process, educators as educators must be able to understand how the potential for immanent nature in the process of student growth and development continues to develop dynamically. As a leading agent in the transformation of educational values ​​to students in classrooms, the implications of the position of educators as educators in fostering students are very large and the impact can be felt immediately for students.
ROADMAP PENELITIAN PRODI PENDIDIKAN AGAMA ISLAM IAIN PONTIANAK TAHUN 2022-2030
Authors: Susanto Rizki , Purwoko Arief Adi , Sundari Weni Ayu , Rosanti Rosanti
Published: July 2023

The research roadmap is an important element for the sustainability of higher education in the field of research. Demands for harmony between research conducted in tertiary institutions and national policies are the main key in responding to community needs in the educational aspect of globalization. The purpose of this study is to design a research roadmap for the IAIN Pontianak PAI Study Program in 2022–2030. This study uses a qualitative descriptive approach with supporting data in the form of research policies on the 2017–2045 National Research Master Plan document, the 2018–2028 National Religious Research Agenda, and the Research and Community Service Roadmap of IAIN Pontianak, as well as data records of the thesis titles of PAI IAIN Pontianak students from 2018–2021. According to the search results, 1) research by PAI students has accommodated RIRN through character research and out-of-school education; ARKAN on 4 themes and 8 sub-themes; and IAIN Pontianak's research roadmap through research with a local Kebornean pattern; and 2) the research roadmap for the PAI IAIN Pontianak study program is directed at achieving graduate profiles and the integration of PAI knowledge with other disciplines so that research results can be published.
Pharmacokinetics of multiple oral doses of acetaminophen in equine neonates
Authors: Faivre Cosette , Wong David M. , Villarino Nicolas F. , Court Michael , Gold Jenifer R.
Published: July 2023

OBJECTIVE

To determine the pharmacokinetics and clinical safety of acetaminophen after oral administration of 40 mg/kg q 12 hours or 60 mg/kg q 24 hours for 14 days.

ANIMALS

12 healthy light-breed neonatal foals.

PROCEDURES

6 foals received acetaminophen at 40 mg/kg q 12 hours and 6 foals received 60 mg/kg q 24 hours for 14 days. The study dates were January 31 to April 15, 2023. Physical examinations were performed daily. Plasma disposition of acetaminophen was determined after the first, mid-point drug administration. Hematology and biochemistry analysis was performed before the study, day 7, and the last day of drug administration. Plasma acetaminophen concentrations were determined by high-performance liquid chromatography. Plasma pharmacokinetic parameters were estimated using noncompartmental analysis.

RESULTS

No statistically significant changes occurred on hematology or biochemistry profiles. Elevations in γ-glutamyl transferase (GGT) and sorbitol dehydrogenase (SDH) were noted in 4 foals at various time points. The maximum plasma concentration (Cmax) occurred within 2 hours for both doses. The 60 mg/kg dose resulted in a larger median Cmax (range) at 28 μg/mL (22–32) than the 40 mg/kg dose at 23 μg/mL (19–27). The median area under the concentration-vs-time curve from 0 to 8 hours (AUC0–8 hour [range]) was 100 h•µg/mL (82–100) at 40 mg/kg and 128 h•µg/mL (120–168) for 60 mg/kg. Trough concentrations decreased over time for both regimens.

CLINICAL RELEVANCE

Foals tolerate oral acetaminophen at 40 mg/kg q 12 hours or 60 mg/kg q 24 hours. Further analgesic and antipyretic studies will help to delineate optimal dosage regimens of acetaminophen to treat foals.
ОБЕСПЕЧЕНИЕ УСЛОВИЙ ОБЛУЧЕНИЯ ОБРАЗЦОВ МЕТАЛЛА В СОСТАВЕ МАТЕРИАЛОВЕДЧЕСКОЙ СБОРКИ ДЛЯ ОБОСНОВАНИЯ ПРОДЛЕНИЯ СРОКА ЭКСПЛУАТАЦИИ РЕАКТОРА БН-600
Authors: Кирилова Е. С. , Радионычева А. А. , Фаракшин М. Р.
Published: July 2023

In order to extend the operation life of the BN-600 reactor, it is necessary to validate operability of the permanent reactor elements – including the neutron reflector – that operate under the conditions with high damaging doses and high temperatures. It can be done through irradiating metal of simulating package inside a materials science assembly inserted in BN-600. The paper describes basic characteristics of the assembly, including design features and irradiation parameters. Described are the basic principles of selecting the location for the materials science assembly in the reactor and for specimens inside the assembly in order to ensure the required irradiation conditions for the metal specimens. With comparing the materials science assembly locations in the reactor core and in the radial blanket, the effect is discussed that the materials science assembly location has upon the characteristics of the reactor standard fuel assemblies and upon the neutron flux field. To calculate the irradiation parameters and the effect that the location has upon the materials science assembly, the same methods and programs are used as for the reactor core design work. The effect of the materials science assembly upon the reactor core neutronic characteristics has been shown to be minimum when the assembly is inserted in the radial blanket.
Perception Investigation Based on the Commuting Cost Model
Authors: Kresnanto Nindyo Cahyo , Putri Wika Harisa , Raharti Rini , Willdan Muhamad , Ramadhan Raihan Iqbal
Published: July 2023

Travel expenses are a significant factor in transportation planning. In addition to the other aspect, travel time, the community considers expense as the necessary element in deciding which mode the communities should take. However, there is a gap between the actual transport expense and the commuter's perception. Thus, comprehensive knowledge is urgently needed particularly to be seen as a major variable in transportation planning that sided with underprivileged groups of transport poverty. The study focused on describing the correlation between income and commuting transportation expenses. The analysis was carried out using two methods. The first method is a descriptive analysis used to provide insight into the patterns and characteristics of the data obtained from interviews with 421 respondents. The second method is regression analysis (linear and nonlinear) to explain the relation pattern between the dependent (commuting transportation expenses) and independent (income) variables. The study's findings demonstrate that transportation expenses follow a negative polynomial regression pattern on income, further implying that the percentage of transportation expenses in low-income communities is significantly higher than those in high-income communities.
Atividades gerenciais do enfermeiro e o processo de trabalho em grupo na estratégia de saúde da família
Authors: Dettmer Jacqueline Alves Borba de Oliveira
Published: July 2023

O enfermeiro atua como intermediador dos profissionais no gerenciamento de conflitos, e deve orientar quanto a soluções para os devidos problemas que acontecem na unidade, analisando-os de acordo com cada necessidade. Evidenciar por meio da literatura as atividades gerenciais do enfermeiro e o processo de trabalho em grupo na Estratégia de Saúde da Família. Trata-se de uma revisão integrativa da literatura. A busca dos trabalhos envolvidos na pesquisa foi realizada nas seguintes bases de dados: SCIELO, LILACS, BDENF E MEDLINE, a partir dos descritores em ciências da saúde: “Estratégia saúde da família”, “Enfermagem”, “Equipe multiprofissional” e “Gerência em saúde”. Os critérios de inclusão foram: publicados no período entre 2016 e 2023, cujo acesso ao periódico era livre aos textos completos, artigos em idioma português, inglês e espanhol e relacionados à temática. Critérios de exclusão foram: artigos duplicados, incompletos, resumos, resenhas, debates, artigos publicados em anais de eventos e indisponíveis na íntegra. O gerenciamento de enfermagem é caracterizado por ser um processo de tomada de decisões, que se diferencia de acordo com a autonomia que esse profissional tem, assim como a relação com a equipe e as regras da instituição de saúde. O presente estudo demonstrou que a ESF é um local de grande importância para que o enfermeiro tenha autonomia em suas atividades gerenciais e com as atividades em grupo que são planejadas pela equipe.
БАНКІВСЬКА СИСТЕМА УКРАЇНИ В УМОВАХ ПАНДЕМІЇ ТА ВІЙНИ: СИМУЛЬТАТИВНА ЕКОНОМЕТРИЧНА МОДЕЛЬ
Authors: Комар Мар’яна , Зомчак Лариса , Пешко Богдана
Published: July 2023

У дослідженні реалізовано симультативну модель банківського сектору України на основі квартальних статистичних даних за 2016-2022 роки. У якості результуючих змінних використано сукупні активи банків, капітал та резерви банків, видатки банків України. За факторні змінні обрано макроекономічні та фінансово-економічні показники: доходи банків, кредити банків, видатки державного бюджету, роздрібний товарооборот, експорт товарів та послуг. Залежності між змінними описано трьома рівняннями. Згідно з першим рівнянням, на сукупні активи банків впливають капітал, резерви, доходи, кредити банків та видатки державного бюджету. Друге рівняння описує залежність капіталу та резервів банків від сукупних активів та видатків банків, а також від макроекономічних показників роздрібного товарообороту, експорту і видатків державного бюджету. У третьому рівнянні досліджено вплив активів, капіталів, доходів та кредитів банків, а також видатків державного бюджету, на видатки банків. Для усіх рівнянь отримано високі значення відношень детермінації та статистично значущі параметри. Виявлено взаємну залежність між мікроекономічними показниками та кількісними характеристиками стану банківської системи на основі статистичних даних, зібраних в період до пандемії, пандемії та війни.
Atividade biológica de extratos de plantas aromáticas condimentares para controle de Rhipicephalus (Boophilus) microplus e Aedes aegypti
Authors: Nascimento Marcela Cristina Nunes do , Pinto Júnior Ricardo Alexandre , Guedes Josiane Paula , Monteiro Luciana Lourenço de Carvalho , Coêlho Francine Alves da Silva , Coêlho Matheus Diniz Gonçalves
Published: July 2023

Uma das maiores ameaças à pecuária na atualidade é o carrapato Rhipicephalus (Boophilus) microplus, e isso se deve ao fato deste ectoparasito causar perda de produção e morte de animais, ou ser agente vetor de doenças como a tristeza parasitária bovina. Outro problema enfrentado atualmente é a Dengue, doença transmitida pelo mosquito Aedes aegypti, que ultimamente tem alcançado elevada morbidade. Em ambos os casos pode-se dizer que um dos principais fatores que dificultam o combate é a resistência que esses vetores adquiriram a produtos químicos utilizados para o controle de suas populações. No presente trabalho objetivou-se testar o efeito do extrato de três plantas aromáticas condimentares, sendo elas Salvia rosmarinus, Ocimum basilicum e Origanum vulgare, quanto a atividade carrapaticida frente a B. microplus e quanto a atividade larvicida frente ao Ae. aegypti. Os vegetais utilizados foram adquiridos em estabelecimentos comerciais especializados, a coleta das teleóginas se deu em uma propriedade rural no município de Pindamonhangaba – SP, e as larvas do díptero foram obtidas em armadilhas montadas utilizando pneus de kart usados. Após execução dos experimentos definiu-se a mortalidade após 72 horas, evidenciando-se ineficácia dos extratos no teste carrapaticida. Entretanto os extratos de S. rosmarinus e O. basilicum apresentaram resultados satisfatórios como larvicidas. Tendo como base os resultados obtidos, conclui-se que as infusões de S. rosmarinus e O. basilicum não apresentaram atividade carrapaticida frente ao carrapato B. microplus e apresentaram atividade larvicida contra Ae. aegypti, destacando-se dessa forma a aplicabilidade de tais preparos para o controle de populações desse díptero.
La forma pasiva de *ditza + u > ditu
Authors: Laka Guenaga Iker Ioseba
Published: July 2023

Se intenta aportar pruebas del presente primitivo de Izan y su posterior participación en la formación del presente del auxiliar transitivo *Edun en forma pasiva. Se propone que D-I - de D-I-ra y D-I-tu es la misma característica de paciente de tercera plural por haber perdido D-I-ra (o más exactamente su anterior *D-I-tza) la -A- que sigue al pronombre personal como en nAiz, gAra, zAra, y por presentarse D-I-tu con la misma “irregularidad”. Por tanto, la teórica *Ditza de Izan más la radical U de *Edun, es decir, *Ditza + U ha producido DItu.
Procrastination in Relation to Academic Achievement among College Students
Authors: - Harpreet Kaur
Published: July 2023

The study examined procrastination in relation to academic achievement among college students. The 282 college students were selected on the basis of convenient and volunteer sampling from 12 selected colleges of Punjab.. The Two way Analysis of variance was used to study main and interaction effect. The interaction effect of academic achievement with stream of study on procrastination among college students. The coefficient of correlation was calculated to find out the relationship between Procrastination and academic achievement among college students. The results revealed that there is no significant difference in mean scores of procrastination in relation to three levels of academic achievement i.e. good academic achievement, average academic achievement and poor academic achievement. There is significant difference in mean scores of procrastination belonging to three stream of study i.e. science, humanities and commerce. The interaction effect of academic achievement and stream of study on procrastination came out to be significant. The coefficient of correlation between procrastination and academic achievement came out to be negative and not significant. On the basis of findings, it is suggested that the principal should organize brain-storming drilling activities/inter-house competitions/quiz/projects at college level in order to boost the intelligence and knowledge of students. The special recognition need to be given to the students, who submit assignments/projects within time. The teacher should give projects/home assignments as creative as one can, in order to reduce procrastination.
Impacto de las competencias tecnológicas de la industria 4.0 en la educación
Authors: Castillo-Martínez Jessica Aracely , Fernández Pérez Jorge A.
Published: July 2023

La importancia de revisar las transformaciones tecnológicas e industriales en el tiempo sirve de base para conocer y prever cuáles serán los nuevos requisitos que exigirá el cambiante mundo laboral desde una visión de la formación profesional. Por lo tanto, el objetivo principal del trabajo fue identificar cuáles son las competencias en términos de tecnología que son requisito y necesidad primordial en los últimos avances tecnológicos como respuesta ante los desafíos tanto del aparato educativo a nivel profesional y laboral en sectores industriales. Para ello, la metodología utilizada fue de carácter descriptivo no experimental, propios del enfoque cualitativo. Por lo que, el trabajo constituye una revisión de literatura a través de una búsqueda sistematizada de documentos en diferentes plataformas. Los hallazgos más relevantes se centran en que las principales competencias tecnológicas que más demanda tienen por parte de la industria y del mundo del trabajo son aquellas en las que se basa la industria 4.0, tales como el big data, los robots, la simulación, los sistemas de integración, el internet de las cosas, la ciberseguridad, el cloud computing, la impresión 3D y la realidad aumentada.
Formalidad y afianzamiento de la democracia paritaria e intercultural de las mujeres en Bolivia
Authors: Santalla Sandoval Jorge Omar
Published: July 2023

El Estado plurinacional de Bolivia reconoce y ejerce la democracia en el que el poder político procede del pueblo, pero no es ejercido por él sino por sus representantes elegidos por medio del voto, generando reflexiones críticas desde la delineación, construcción primigenia de los grupos de cuotas, su evolución integral con formalismos y conquista de la democracia paritaria e intercultural con perspectiva de género de las mujeres, proveyéndoles el afianzamiento y consolidación a través de las normas legales vigentes, respecto a la equivalencia, paridad y alternancia en la participación democrática de las féminas, fin que se halla orientado a darle una «voz efectiva» por las décadas que fueron relegadas, desatendidas, desamparadas y abandonadas, su actividad política como un todo y simultáneamente su presencia en todos los niveles del Estado en los procesos de toma de decisiones, acceso al poder y equidad.