bluuebunny/crossref_metadata_2025 huggingface dataset:
Multilinguismo e políticas linguísticas: o caso dos Warao em Belém
Authors: Silva Deywela Thayssa Xavier da , Brandão Ana Paula Barros
Published: August 2023

A língua Warao é uma língua originária da Venezuela, mas atualmente por conta do intenso fluxo migratório é falada também no Brasil. Diante da presença Warao em todas as regiões do Brasil surge a necessidade de refletir sobre as especificidades linguísticas do referido povo. Dessa forma, o objetivo deste trabalho é apresentar o perfil sociolinguístico dos Warao e também, refletir sobre questões relacionadas ao multilinguismo e as políticas linguísticas voltadas para essa população. Para isso apresentamos algumas das políticas linguísticas e políticas de inclusão governamentais e não governamentais já implementadas. A fundamentação teórica deste trabalho ancora-se nas reflexões sobre diversidade linguística e multilinguismo de Amaral (2011), Gomes (2020) e Morello (2012); nos estudos sobre políticas linguísticas de Calvet (2007), Oliveira (2016) e Rocha e Hamel (2020) e, também, na análise sobre as políticas linguísticas previstas na LDB (1996) e nas Diretrizes para a política Nacional de Educação Escolar Indígena (1994).
Własności i prawa przyrody w esencjalizmie dyspozycyjnym
Authors: Wodzisz Rafał
Published: August 2023

The aim of this paper is to articulate dispositonal essentialism (DE) as a viable position in the discussions considering properties and laws of nature. In the first part of the article there are given several "must have" trades of properties in DE. They are followed by the conceptions themselves. The last part of the article brings a little insight about ceteris paribus laws in DE.
CASQ2: clinical and genetic insights into catecholaminergic polymorphic ventricular tachycardia across three families
Authors: Kulbachinskaya Ekaterina K. , Bereznitskaya Vera V.
Published: August 2023

Catecholaminergic polymorphic ventricular tachycardia is a primary channelopathy with a high mortality rate if left untreated. In 3 to 5% of catecholaminergic polymorphic ventricular tachycardia patients, mutations in the CASQ2 gene, either in a homozygous or compound heterozygous form, have been identified. In this article, we present a clinical case series of patients from three unrelated families with mutations in the CASQ2 gene, including three novel mutations (p.Leu167Pro, p.Asp325GlyfsTer7, and p.Glu259Ter). All our patients with homozygous or compound heterozygous CASQ2 gene mutations experienced a severe disease course, with early manifestations and resistance to specific anti-arrhythmic treatment, including beta-blockers. They exhibited a wide range of heart rhythm abnormalities, both ventricular and supraventricular, and had a high risk of sudden cardiac death. In all cases, ventricular heart arrhythmias persisted despite regular treatment with specific anti-arrhythmic agents, unless selective left-sided sympathectomy had been performed. The management of this patient group emphasized an individualized approach, combining medical and surgical treatment methods tailored to each patient's unique needs and condition.
Understanding the Genetic Basis of Yield-related Traits in Little Millet (Panicum sumatrense Roth. ex. Roem. and Schultz.) Germplasm through Association and Diversity Analysis
Authors: Amaravel M. , Nirmalakumari A. , Geetha S. , Sathiya K. , Renuka R.
Published: August 2023

Background: Little millet is an important crop grown by tribal farmers in India. Genetic variability can be exploited to develop new varieties with higher yield. However, yield is complex and depends on multiple interconnected component characters. Diversity analyses, such as D2 analysis, are used to evaluate the diversity among genotypes and determine the traits that contribute the most diversity in a given population. These analyses are crucial for achieving the goal of developing new varieties with increased yield. Methods: In this study, 323 little millet genotypes were evaluated using an Augmented RCBD, focusing on ten quantitative traits. The experiment was conducted during the rabi season of 2020-2021, and good agronomic practices were followed. D square cluster analysis and path analysis were used to analyze the data, with the "R" tool and the "biotools" and "agricolae" packages, respectively. Result: In this study, 323 little millet genotypes classified into thirteen distinct clusters based on Mahalanobis's D2 statistics, reflecting differences in their phenotypic characteristics. The largest cluster (cluster I) included 243 genotypes, while the smallest clusters (Cluster IX, Cluster X, Cluster XI, Cluster XII and Cluster XIII) had only 1 genotype. The inter-cluster distance varied, with the largest value (577.7) between cluster V and XII. This analysis can be useful for identifying desirable genotypes and understanding the population's genetic diversity and structure.
Assessment of the Physical, Chemical, Yield and Nutritional Quality Traits of Tropical, Temperate and Wild Dry Bean Species in Vietnam
Authors: Ha P.T.T. , Hiep T.T.M. , Thai H.N. , Liem N.T. , Thuy D.T.K. , Henry R.J.
Published: August 2023

Background: Assessing agronomic and nutritional characteristics is one of the primary goals for assisting plant scientists in selecting promising grain legume crops for future food and nutritional security and increasing the income of smallholder farmers. Methods: The experiment was conducted from September 2021 to February 2022 at the greenhouse of GRIS, Ton Duc Thang University, Vietnam. Yield components, agronomic characteristics and biochemical and nutritional parameters of two varieties of tropical beans (Velvet White Bean and Red Cowpea), two varieties of temperate beans (Dwarf Stick Bean and Soybean) and two varieties of wild beans when grown in Vietnam were evaluated in the present study. Result: The results revealed the presence of a wide range of phenotypic variations in dry bean germplasm. The biochemical and nutritional properties of the bean types investigated revealed that the Velvet White Bean had a higher phenol content (0.42 mg GAE g-1) and a lower phytic acid concentration (2.87 µg mL-1) than the other species. The Dwarf stick vean had the highest flavonoid concentration among the types (0.017 mg RE g-1) while the crude protein content of soybean (38.2 mg g-1) was the highest. These findings serve as a foundation for breeders in selecting promising legumes to breed for Vietnam.
RISK MANAGEMENT APPLIED TO AEROSPACE ENGINEERING DESIGN
Authors:   National Institute for Aerospace Research “Elie Carafoli”, Bucharest, Romania, ANDREI Irina-Carmen , STROE Gabriela-Liliana ,   National Institute for Aerospace Research “Elie Carafoli”, Bucharest, Romania, BERBENTE Sorin ,   National Institute for Aerospace Research “Elie Carafoli”, Bucharest, Romania, PRISACARIU Vasile ,   ”Henri Coandă” Air Force Academy, Braşov, Romania, COSTEA Emil ,   National Institute for Aerospace Research “Elie Carafoli”, Bucharest, Romania, POPESCU onel ,   Institute for Theoretical and Experimental Analysis of Aeronautical Structures, Bucharest, Romania, FILIPESCU Octavian Ioan ,   “Politehnica” University of Bucharest, Faculty of Mechanical Engineering and Mechatronics, Romania
Published: August 2023

The intent of this paper is to present applications of risk management to aerospace engineering design; the study was focused on composite materials design and manufacturing of parts, assemblies from aircraft and spacecraft, such as aerostructures, fuselage, aircraft wings and controls, jet engines parts such as fan blades, widely used in aerospace engineering. The use of composites in aerospace engineering provides significant reduction of costs for manufacturing, technology and operation, provided adequate management. Management in composites design, manufacturing and technology may allow to achieving performance and cost-effectiveness for such aerospace engineering parts, which are critical from the safety standpoint
MODERN AIRCRAFT BRAKING SYSTEMS
Authors:   University of Craiova, Faculty of Electrical Engineering, Romania, DINCA Liviu , CORCAU Jenica-Ileana ,   University of Craiova, Faculty of Electrical Engineering, Romania, CONDREA Dmitrii ,   University of Craiova, Faculty of Electrical Engineering, Romania
Published: August 2023

This paper presents some problems concerning the present trends in the field of aircraft braking systems. New solutions like electro-mechanical or electro-hydrostatic actuators are considered the future, but some big aircraft producers do not renounce yet to classical electro-hydraulic braking systems. New solutions are not generally accepted, they have to prove their reliability and that they bring considerable more advantages than penalties.
PROJECT MANAGEMENT APPLIED FOR COMPOSITE MATERIALS USED IN AERONAUTICS. CARBON FIBER AND NANO-ADDITIVES
Authors:   “POLITEHNICA” University of Bucharest, Faculty of Mechanical Engineering and Mechatronics, Machine Parts and Tribology Department, Romania, STOICA Gina Florica , ANDREI Irina-Carmen ,   National Institute for Aerospace Research “Elie Carafoli”, Bucharest, Romania, CRIŞAN Nicoleta ,   “POLITEHNICA” University of Bucharest, Faculty of Industrial Engineering and Robotics, Strength of Materials Department, Bucharest, Romania, PRISECARU Delia ,   “POLITEHNICA” University of Bucharest, Faculty of Mechanical Engineering and Mechatronics, Machine Parts and Tribology Department, Romania, ŞTEFAN Adriana ,   National Institute for Aerospace Research “Elie Carafoli”, Bucharest, Romania, STOICA Cristian ,   Romanian Research and Development Institute for Gas Turbines, Bucharest, Romania, GRECULESCU Anca ,   “POLITEHNICA” University of Bucharest, Faculty of Mechanical Engineering and Mechatronics, Machine Parts and Tribology Department, Romania, TACHEREAU Sylvain ,   ENIT, l'École Nationale d'Ingénieurs de Tarbes, France, VEELERS Dylan ,   Saxion University of Applied Sciences, Enschede, the Netherlands, SZYMAŃSKA Katharzyna ,   University of Technology, Lodz, Poland, COZMA-IVAN Paul ,   “POLITEHNICA” University of Bucharest, Faculty of Mechanical Engineering and Mechatronics, Machine Parts and Tribology Department, Romania
Published: August 2023

This paper presents the results of theoretical and applied research related to composite materials, carbon fiber and nano-additives. The objective of this work is to investigate the properties and behavior of custom designed composite materials which are intended for applications in aerospace engineering. The holistic approach is expressed by the structure of this research project which consists of the technical part and the economic part, that is analyzed in terms of project management. The specificity of the work is given by the requirements of the European Project Semester EPS, where international teams of students actively experience a multidisciplinary and multicultural project for one semester in another university, which has developed research and industrial partnerships. For developing such project, the approach provided by INCAS as Research Partner is oriented towards Problem Based Learning and Project Organized Learning. The University as Organizer provides Project Related Courses and some complementary Project Organized Learning. The research was oriented towards the customized design and analyzing of composite materials samples for potential use in aerospace engineering, the development and validation of materials and methodologies. The benefits of the research project are related to the applications of composite materials and in the subsidiary to allow the students learn valuable professional lessons and experience from this research project.
Discussões sobre expertise e o papel dos experts em decisões
Authors: Farias Luciana de , Pinheiro Daniela Albini , Fontolan Marina
Published: August 2023

O objetivo do artigo é trazer os principais pontos da discussão sobre expertise e o papel dos experts em tomadas de decisões com base em duas autoras em específico: Dorothy Nelkin e Helga Nowotny. Por meio de revisão bibliográfica, apresentamos brevemente um histórico dos Estudos Sociais da Ciência e da Tecnologia (ESCT). Em seguida, exploramos o tema da expertise e do papel dos experts como objeto de estudo e adentramos nas implicações do aumento do envolvimento dos cientistas em áreas controversas, discutidas por Dorothy Nelkin em “The Political Impact of Technical Expertise”, de 1975, e Helga Nowotny em “Democratising expertise and socially robust knowledge”, de 2003. Concluímos que a relação entre expertise-conhecimento-tomada de decisão é um tema que vem sendo explorado pelos ESCT há décadas e que ainda está em discussão. A contribuição dos estudos abordados é reconhecer que a mobilização do conhecimento científico como expertise em questões controversas é inerentemente conflituosa e permeada por incertezas, e identificar e informar sobre tais incertezas deve fazer parte da solução de tais controvérsias, superando a ideia de que o papel da ciência é reduzir as incertezas a zero.
Diplomacia científica e história das ciências
Authors: Silva Luciana Vieira Souza da
Published: August 2023

O objetivo deste artigo é apresentar reflexões iniciais de ordem teórica e metodológica a respeito da apropriação do conceito de diplomacia científica na área de história das ciências, cujos resultados têm se mostrado promissores. Na primeira seção, apresenta as principais definições e problematizações do conceito de diplomacia científica, um termo recentemente surgido no vocabulário das relações internacionais, mas uma prática antiga dos campos diplomático e científico. Em seguida, apresenta as apropriações do conceito pela historiografia das ciências, a partir de comentários sobre a literatura produzida entre 2020 e 2021, e publicada em revistas das áreas de relações internacionais, história contemporânea e história das ciências. Por fim, apresenta comentários sobre experiências de pesquisa na área da história da diplomacia científica no Brasil, a fim de auxiliar na elaboração de pesquisas futuras que visem a analisar as relações entre ciência e diplomacia em uma perspectiva histórica, com sugestões a respeito dos arquivos a serem visitados, as tipologias documentais a serem coletadas, a forma de análise das fontes e os cuidados a serem tomados na etapa de elaboração da narrativa histórica.
The Correlation between Blood Glucose and Lipid Profile with Skin tag
Authors: Wahyu Lestari  , Sulamsih Sri Budini  , Cut Yunita  , Hendra Zufry  , Sitti Hajar
Published: August 2023

Background: Skin tags or acrochordons are benign fibroepithelioma skin tumors with soft consistency, usually pedunculated, primarily originating from the dermis. High levels of blood sugar and a high lipid profile are risk factors for inflammation and hormonal imbalance, which can contribute to the development of skin tags. Purpose: The objective of this study is to identify the association between blood sugar and lipid profile with skin tags. Methods: This study is a cross-sectional study conducted from April to August 2019 at the Dermatovenereology and Endocrine Policlinic, Dr. Zainoel Abidin General Hospital, Banda Aceh. The sampling method of this study was consecutive sampling with 60 samples that met the inclusion and exclusion criteria. A blood glucose, lipid profile, and skin tag examination was conducted on all subjects. Result: The majority of the subjects are women (61.5%), have an average age of 41-50 years old (43.3%), are obese (41.7%), and have one to five lessions of 1-5 (53.3%). There was a significant correlation between blood glucose, 2 hours post-prandial, total cholesterol, triglyceride, high-density lipoprotein (HDL), and low-density lipoprotein (LDL) levels with skin tags with Spearman’s correlation values of 0.645, 0.645, 0.794, 0.704, 0.606, and 0.606 consecutively. Conclusion: A high level of blood sugar and lipid profile, whether it is total cholesterol, triglycerides, HDL, or LDL level, can contribute to the development of skin tags.
Antifungal Activity of Rosemary (Rosmarinus officinalis L.) Emulsion Gel Compared to Nystatin on Candida albicans Stored Isolate from HIV/AIDS Patients with Oral Candidiasis
Authors: Wardiana Maya , Astindari  , Ervianti Evy , Afif Nurul Hidayati  , Diah Mira Indramaya  , Pepy Dwi Endraswari  , Budi Utomo  , Dwi Murtiastutik
Published: August 2023

Background: Oral candidiasis (OC), frequently caused by Candida albicans, is the most common opportunistic infection in HIV/AIDS patients. Topical treatment for OC is limited. In vitro study revealed rosemary (Rosmarinus officinalis L.) essential oil has an antifungal effect. However, the essential oil is volatile and is not recommended to be applied to the skin and mucosa; therefore, emulsion gel (emulgel) is made. Purpose: This study was conducted to evaluate the antifungal activity of rosemary emulgel 6.25%, 25%, 37.5%, and 50% compared to nystatin. Methods: This study is an in vitro test using the disk diffusion method to d  etermine the antifungal activity shown by the inhibitory zones of rosemary emulgel at 6.25%, 25%, 37.5%, and 50% compared to nystatin to stored isolates of C. albicans from HIV/AIDS patients with OC. Result: Rosemary emulgel 6.25% dan 25% did not show antifungal activity because no inhibitory zone was shown. The inhibitory zone diameter provided by rosemary emulgel 37.5%; 50%; and nystatin against C. albicans isolates were 3.17±3.763 mm; 7.00±4.107 mm; and 30.13±5.319 mm respectively. Significant differences in antifungal activity were shown by the inhibitory zone diameter provided between rosemary emulgel 37.5%, 50%, and nystatin (p<0,05). Conclusion: Rosemary emulgel 37.5% dan 50% had antifungal activity showed by the formation of inhibitory zone against Candida species isolates in disk diffusion method even though it was weaker compared to nystatin as a standard antifungal.
Is Health Education On Anemia Increasing Iron Supplementation Consumption In Adolescent Girls? : A Systematic Review
Authors: Berliana Farah Yanisah  , Sri Widati
Published: August 2023

Background: Approximately 1.62 billion people worldwide suffer from anemia, and about half of all anemia can result from iron deficiency. Adolescence is also considered the golden time for interventions to control anemia. It is also the right time to create a nutritional foundation for the labor of a child in the future. Nutrition education in schools has been shown to be effective in improving young people's knowledge, attitudes, and practices regarding anemia prevention. Objectives: This study aims to analyze the effects of iron supplementation and nutritional education on anemia in adolescent girls and the correlation with iron supplementation consumption so that anemia can be prevented as early as possible since adolescence. Discussion: This study showed that health education on anemia increases adolescents’ knowledge and also weekly Iron–Folic Acid Supplementation (WIFS) health education can be effective in reducing the prevalence of anemia in adolescent girls by increasing the Hb level. Conclusions: These studies conclude that nutritional education increased the level of knowledge, attitude, and practice of adolescent girls and also led to an increase in Hemoglobin levels which can prevent anemia. Health education on anemia increase knowledge and practice of iron supplementation among adolescent girl. Increasing knowledge and practice in consuming iron supplementation will also increase the level of hemoglobin.
The Culture of Drinking Herbal Medicine in Pregnant Women: A Phenomenological Study
Authors: Fadlilah Nazilatul , Shrimarti Rukmini Devy  , Mohammad Zainal Fatah  , Mangestuti Agil  , Ahmaniyah
Published: August 2023

Background: Pregnant women who drink herbal medicine can increase the risk of meconium amniotic fluid, and meconium amniotic fluid is a risk factor for asphyxia in newborns. Objectives: Identify three forms of culture in drinking herbal medicine in pregnant women, namely the mother's values and ideas about drinking herbal medicine, herbal drinking activities, and material on the culture of drinking herbal medicine. Methods: This research is a qualitative method with a phenomenological approach. Informants in this study consisted of pregnant women and key informants consisted of families of pregnant women, cadres, ustadzah, midwives, and herbal medicine providers. Results: The cultural forms of drinking herbal medicine include: 1) Values and Ideas. Drinking herbal medicine for pregnant women is still practiced because of their subjective norms and normative beliefs from the surrounding environment. All informants believed that herbal medicine could provide benefits rather than negative effects, and only midwives stated that herbal medicine had negative effects, namely meconium amniotic fluid, and even asphyxia. 2) The activity of drinking herbal medicine. Pregnant women drink herbal medicine from the beginning of pregnancy until delivery. The frequency of taking herbal medicine was various. Religious figures and community leaders have an important role in the culture of drinking herbal medicine. 3) Herbal ingredients. The herbs consumed by each informant were different, there were informants who consumed homemade herbs and bought them at the market. Conclusions: The culture of drinking herbal medicine is still carried out because the local community's belief about the benefits of herbal medicine is still high, and lack of public knowledge about the effects of drinking herbal medicine on pregnant women.
Development of soft dry electrodes: from materials to structure design
Authors: Liu Hua , Chen Xiaodi , Wang Zihao , Liu Yan , Liang Cuiyuan , Zhu Ming , Qi Dianpeng
Published: August 2023

Bioelectric signals reflect our daily physiological activities, which can be recorded in the form of electroencephalography, electrocardiography, electromyography, etc. The traditional Ag/AgCl wet electrode is the gold standard for clinical monitoring of bioelectrical signals at present, while complicated preparation and gel evaporation limit its long-term application. Therefore, it is meaningful to research dry electrodes without conductive paste or additional adhesives. Unfortunately, the high interface impedance between electrodes and skin is a fatal defect of dry electrodes, which leads to excessive noise levels and poor signal quality. Consequently, more efforts are required to achieve conformal contact between dry electrodes and skin to reduce the contact impedance. From this perspective, we review the recent progress in capacitive electrodes, invasive microneedle electrodes, and common-contact dry electrodes. Material selection and structural design to obtain conformal contact are highlighted. Finally, we propose the future development direction of dry electrodes.
Advances in printing techniques for thermoelectric materials and devices
Authors: Hong Min , Sun Shuai , Lyu Wanyu , Li Meng , Liu Weidi , Shi Xiao-Lei , Chen Zhi-Gang
Published: August 2023

Thermoelectric materials and devices have garnered significant attention in recent years due to their potential for converting waste heat into usable electricity, opening new avenues for sustainable energy harvesting. As research in the field of thermoelectric materials and devices continues to grow, so does the need for efficient and scalable fabrication methods. Among various fabrication techniques, printing methods have emerged as promising approaches to producing thermoelectric materials and devices, offering advantages such as low cost, high throughput, and design flexibility. Here, we overview the recent advances in printing methods for the fabrication of thermoelectric materials and devices. We discuss the key principles, challenges, and opportunities associated with various printing techniques, including screen printing, inkjet printing, and 3D printing, with a focus on their applications in thermoelectric materials and devices. Furthermore, we highlight the progress made in optimizing the printing parameters, ink formulations, and post-processing methods to enhance the thermoelectric performance of printed materials and devices. Finally, we provide insights into the prospects and potential research directions in the field of printing methods for thermoelectric materials and devices. This review aims to provide a comprehensive overview of the state-of-the-art printing techniques for thermoelectric materials and devices and to serve as a reference for researchers and practitioners working in this rapidly growing field.
Read this First! How to Prepare a Manuscript for Submission to a Chemical Science Journal
Authors: Dekanski Anja , Dekanski Aleksandar
Published: August 2023

In addition to the subject-matter theoretical knowledge acquired during undergraduate and especially postgraduate studies future young scientists must also acquire the accompanying academic skills. This skillset will enable them to plan and conduct research in accordance with the scientific method, but also to present the results of that research in suitable forms. No result and no new knowledge derived from research is valuable in itself, as long as it is not presented to the scientific community and society as a whole. This dissemination is most often done through the peer-reviewed publishing in scientific journals. Hence acquiring the skill of writing scientific publications must be an integral part of education, eg. part of the acquired academic skills. However, currently that is not the case in all scientific environments and a significant number of (young) scientists and researchers do not possess all the necessary knowledge and skills to write academic articles, especially when it comes to the standard form and technical preparations. This skill-gap often results in a significant number of submitted papers to be rejected or sent back for resubmission even before they reach the Editor's desk. In an effort to provide an academic-writing-skill resource for young academics in the field, this article, points out the general principles of a well-written and prepared paper, indicates the most common errors and omissions, and suggests ways to prevent them. In addition, the article is considering the current state of academic skills in, primarily, less developed scientific environments. and the causes of such a state.
Study of Structural Similarities between Tubulin, TMC1, and FtsZ Proteins as They Relate to Mechanosensory Transduction in the Context of the Orch OR Theory of Consciousness
Authors: Ruggiero Marco
Published: August 2023

Recent evidence obtained in murine atrial cardiomyocytes suggests that the behavior of tubulin, a constituent of microtubules, is influenced by audible sounds. In the present study, the sequence and the structure of murine and human tubulins were compared with those of human TMC1 (Transmembrane channel-like protein 1), a sound-sensitive protein that is responsible for forming the pore of mechanosensory transduction channels in the hair cells of the inner ear of vertebrates, and with those of bacterial FtsZ (Filamenting temperature-sensitive mutant Z), a bacterial protein homologous to tubulin. The results show that mouse and human alpha-tubulin are 100% identical, whereas sequence homology of human TMC1 and human tubulin alpha 1A chain is scarce, with only 17.31% identity. A higher degree of similarity was observed in the presence of aromatic amino acids as well as in the propensity to form alpha-helices. Based on these results, it is hypothesized that the response of tubulin to audible sounds is mediated by the external alpha-helices as it occurs in TMC1. The sequence homology of human TMC1 and FtsZ from Lactobacillus johnsonii, is moderate with 23.40% identity, however higher than that between TMC1 and tubulin. The overall presence of aromatic amino acids in FtsZ is scarce, but helix propensity is significant. These results are discussed in the context of Orch OR, a theory that postulates that consciousness emerges from quantum computations occurring in microtubules of neurons via information processing mediated by aromatic amino acids of tubulin.
An Algebraic Proof of the Jacobian Conjecture
Authors: Xiao Qianghui
Published: August 2023

In this paper, a short survey of the existed results concerning the Jacobian Conjecture is first given. Then the 3-fold linear type polynomial map will be analyzed in detail. The expansion of the Jacobian condition is deduced to obtain its equivalent algebraic equations, and the Jacobian condition will be analyzed to derive two coordinate transformations that can maintain the invariance of the Jacobian condition. Finally, it is proved by mathematical induction method that one general chain expression presented in this paper is just the inverse polynomial map of 3-fold linear type polynomial map, i.e. LJC(n,[3]) holds such that the Jacobian Conjecture holds.
Protective effect of procyanidin-rich grape seed extract against Gram-negative virulence factors
Authors: Nicolosi Roberta Maria , Bonincontro Graziana , Imperia Elena , Badiali Camilla , De Vita Daniela , Sciubba Fabio , Dugo Laura , Guarino Michele Pier Luca , Altomare Annamaria , Simonetti Giovanna , Pasqua Gabriella
Published: August 2023

Biofilm formation and lipopolysaccharide (LPS) are implicated in the pathogenesis of gastrointestinal (GI) diseases caused by Gram-negative such as Escherichia coli and Salmonella enterica serovar Typhimurium. Grape seeds, wine industry by-products, have antioxidant, antimicrobial, and anti-inflammatory activities. In the present study, the protective effect of procyanidin-rich grape seed extract (prGSE), from unfermented pomace of Vitis vinifera cv Bellone, on bacterial LPS-induced oxidative stress and epithelial barrier integrity damages has been studied in a model of Caco-2 cells. The in vitro activity of prGSE against formation of biofilm of S. Typhimurium and E. coli, has been investigated. In vivo, prGSE activity using infected Galleria mellonella larvae has been evaluated. The results showed that the prGSE, if administered with LPS, can significantly reduce the LPS-induced permeability alteration. Moreover, the ability of the extract to prevent Reactive Oxygen Species (ROS) production induced by LPS treatment of Caco-2 cells has been demonstrated. prGSE inhibited the biofilm formation of E. coli and S. Typhimurium. In in vivo activity, increased survival of infected G. mellonella larvae after treatment with prGSE has been demonstrated. In conclusion, grape seed extracts could be used in the reduction of GI damage caused by bacterial endotoxin and biofilm of Gram-negative bacteria.
Orai3 calcium channel regulates oral/oropharyngeal cancer stemness via ID1 expression
Authors: Nguyen Anthony , Sung Youngjae , Lee Sung Hee , Martin Charlotte Ellen , Srikanth Sonal , Kang Mo K. , Kim Reuben , Park No-Hee , Gwack Yousang , Kim Yong , Shin Ki-Hyuk
Published: August 2023

Emerging evidence indicates that intracellular calcium (Ca2+) levels and their regulatory proteins play essential roles in normal stem cell proliferation and differentiation. Cancer stem-like cells (CSCs) are subpopulations of cancer cells that retain characteristics similar to stem cells and play an essential role in cancer progression. Recent studies have reported that the Orai3 calcium channel plays an oncogenic role in human cancer. However, its role in CSC remains underexplored. In this study, we explored the effects of Orai3 in the progression and stemness of oral/oropharyngeal squamous cell carcinoma (OSCC). Orai3 expression was increased in a stepwise manner during the progression of OSCC. In addition, Orai3 was highly enriched in CSC populations of OSCC. Ectopic Orai3 expression in non-tumorigenic immortalized oral epithelial cells increased intracellular Ca2+ levels, acquiring malignant growth and CSC properties. Conversely, silencing of endogenous Orai3 in OSCC cells suppressed CSC phenotype, indicating a pivotal role of Orai3 in CSC regulation. Moreover, Orai3 markedly increased the expression of inhibitor of DNA binding 1 (ID1), a stemness transcription factor. Orai3 and ID1 were highly expressed in CSCs compared to non-CSCs, implying the functional importance of the Orai3/ID1 axis in CSC regulation. Furthermore, suppression of ID1 abrogated CSC phenotype in the cell with ectopic Orai3 overexpression and OSCC. Our study reveals that Orai3 is a novel functional CSC regulator in OSCC and further suggests that Orai3 plays an oncogenic role in OSCC by promoting cancer stemness via ID1 upregulation.
Tracing the evolution of reviews and research articles in the biomedical literature: a multi-dimensional analysis of abstracts
Authors: Guizzardi Stefano , Colangelo Maria Teresa , Mirandola Prisco , Galli Carlo
Published: August 2023

We have previously reported on the diachronical changes in the narrative structure of research articles (RAs) and review manuscripts, using corpora of abstracts from MEDLINE. The present study investigates 5 linguistic dimensions (D1-5) of the text, following Biber’s well established Multimensional Analysis, on the same corpora, to assess how writing practices have changed in these two biomedical literature sub-genres over the years. Our analysis encompassed a sample of more than 1.2 million subtracts from manuscripts that were published over the course of more than 30 years. Both RAs and reviews have reinforced their informational, emotionally detached tone (D1), and have progressively refrained from the use of narrative devices (D2), while increasing their context-independent content (D3). Both RAs and reviews have displayed low levels of overt persuasion (D4), while steering away from abstract content to focus on a more marked author agency and identity adfirmation. When the linguistic features that underly these 5 dimensions are compared, it becomes apparent that RAs and review papers have often changed quite independently, both usually converging to standardized stylistic canons.
Energy-Efficient Opportunistic Routing Algorithm for Post-disaster Mine Internet of Things Networks
Authors: Zhao Qing , Yang Wei , Zhang Li Ya
Published: August 2023

The Mine Internet of Things (MIoT), as a key technology for reconstructing post-disaster communication networks, enables to realize the safety monitoring and controlling of the affected roadway. However, due to the challenging underground mine environment, the MIoT suffers from severe signal attenuation, vulnerable nodes, and limited energy, which result in low network reliability of the post-disaster MIoT. To improve the transmission reliability as well as to reduce energy consumption, a directional-area-forwarding-based energy-efficient opportunistic routing (DEOR) for the post-disaster MIoT is proposed. DEOR defines a forwarding zone (FZ) for each node to route packets toward the sink. The candidate forwarding set (CFS) is constructed by the nodes within the FZ that satisfy the energy constraint and the neighboring node degree constraint. The nodes in CFS are prioritized based on the routing quality evaluation by taking the local attributes of nodes into consideration, such as the directional angle, transmission distance, and residual energy. DEOR adopts a recovery mechanism to address the issue of void nodes. The simulation results validate that the proposed DEOR outperforms ORR, OBRN and ECSOR in terms of energy consumption, average hop count, packet delivery rate, and network lifetime.
Dose-Dependent Shift in Relative Contribution of Homologous Recombination to DNA Repair after Low-LET Ionizing Radiation Exposure: Empirical Evidence and Numerical Simulation
Authors: Belov Oleg , Chigasova Anna , Pustovalova Margarita , Osipov Andrey , Eremin Petr , Vorobyeva Natalia , Osipov Andreyan N.
Published: August 2023

Relative contribution of different repair pathways to the radiation-induced DNA damage responses remains a challenging issue of studying the radiation injury endpoints. Comparative manifestation of homologous recombination (HR) after application of different radiation doses greatly determines an overall effectiveness of recovery in dividing cell after irradiation, since HR is an error-free mechanism intended for repair of DNA double strand breaks (DSB) during S/G2 phases of cell cycle. In this article, we present an experimentally observed evidence of dose-dependent shift in relative contribution of HR in human fibroblasts after X-ray exposure at doses 20-1000 mGy, which is also supported by quantitative modeling of DNA DSB repair. Our findings indicate that the radiation dose increase leads to dose-dependent decrease in relative contribution of HR into the entire repair process.
Variability in the Bioactivities of Wild Populations of Baccharis crispa Spreng. (Asteraceae) from Córdoba, Argentina: Screening of Cytotoxic and Antiviral Activity
Authors: Lingua Giuliana , Chaves Ana Guadalupe , Aguilar Juan Javier , Martinez Florencia , Torres Lorena , Lucini Enrique , Contigiani Marta , Nuñez Montoya Susana , Konigheim Brenda S.
Published: August 2023

Medicinal plants are being tested as options to prevent infectious diseases in many countries. Baccharis crispa Spreng. (Asteraceae), is a native medicinal species widely used throughout South America. Our objective was to evaluate the antiviral activity of four wild populations of B. crispa from the province of Córdoba (Argentina) and determine if there is variability between them. The cytotoxicity of the extracts (chlorofom, ethanol and aquose) was evaluated by the neutral red uptake method. Using the plaque-forming unit reduction assay, virucidal and antiviral activity against Herpes Simplex type 1 and Chikungunya viruses were tested. Phytochemical screening of each extract was also performed. Puesto Pedernera (PP) population showed the best antiviral and virucidal effect, standing out the ethanolic extract as the least toxic and with the best inhibitory activity against both viral models. Villa del Parque (VP) population was inactive, regardless of the extract and the virus tested. The results revealed that extracts bioactivities vary significantly depending on the geographic area of collection, with PP and VP populations showing the most significant variability, not only in activity but also in chemical composition. These findings support the potential use of extracts as a source of therapeutic agents against different viruses.
Anisotropic Universes Sourced by Modified Chaplygin Gas
Authors: Ray Saibal , Tripathy Sunil , Sengupta Rikpratik , Bal Bibhudutta , Rout Sonali
Published: August 2023

In this work we perform a comparative study of the Kantowski-Sachs (KS) and Bianchi-I anisotropic universes with Modified Chaplygin gas (MCG) as matter source. We obtain the volume and scale factors as solutions to the Einstein Field Equations (EFEs) for the anisotropic universes, and check whether the initial anisotropy is washed out or not for different values of the MCG parameters present in the solution by obtaining the anisotropy parameters for each solution. The deceleration parameter is also obtained for each solution, the significance of which is discussed in the concluding section. Interestingly there are a number of notable results that appear from our study which help us to compare and contrast the two different anisotropic models along with proper understanding of the role of MCG as matter source in these models.
Effects of Difluorophenyl Substituents on Structural, Redox, and Magnetic Properties of Blatter Radicals
Authors: Gulyaev Dmitry , Serykh Andrey , Tretyakov Evgeny , Akyeva Anna , Syroeshkin Mikhail , Gorbunov Dmitry , Maltseva Svetlana , Gritsan Nina , Romanenko Galina , Bogomyakov Artem
Published: August 2023

Blatter radicals 1-(3,4-difluorophenyl)- (1a) and 1-(2,4-difluorophenyl)-3-phenyl-1,4-dihydrobenzo[e][1,2,4]triazin-4-yl (1b) were prepared in good yields through oxidation of the corresponding amidrazones using MnO2 in dry CH2Cl2. Cyclic voltammetry showed that both radicals are oxidized and reduced chemically and electrochemically reversibly in accordance with –1/0 and 0/+1 processes. EPR spectroscopy indicated that spin density is mainly delocalized on the triazinyl moiety of the heterocycle. Structure of all paramagnets was unambiguously confirmed by single-crystal X-ray diffraction, and two different 1D chains of alternating radicals were identified. 3,4-Difluorophenyl-derivatives 1a are packed into columns composed of two kinds of alternating centrosymmetric dimers, having comparatively short intermolecular distances. In crystals of 2,4-difluorophenyl-derivative 1b, the parallel arrangement of bicyclic moieties and phenyl rings favors the formation of 1D regular chains wherein the radicals are related by translation parallel to the crystallographic stacking axis. Magnetic susceptibility measurements in the 2–300 K region showed that in crystals of the radicals, strong antiferromagnetic interactions are dominant. Subsequent fitting of the dependence of T on T with 12-membered looped uniform stacks gave the following best-fit parameters: for 1a, g = 2.01 ± 0.05, J/kB = –292 ± 10 K; for 1b, g = 2.04 ± 0.1J/kB = –222 ± 17 K. For comparison, in a nonfluorinated related radical, there are only very weak intermolecular interactions along the columns (J/kB = –2.2 ± 0.2 K). These results illustrate the magnitude of the influence of the fluorine atoms introduced into Blatter radicals on their structure and magnetic properties.
Visco Elastic Properties of Polypropylene during Crystallization and Fusion; Experimental and Phenomenological Modelling
Authors: Billon Noëlle , Castellani Romain , Bouvard Jean Luc , Rival Guilhem
Published: August 2023

This paper deals with the viscoelastic behavior during crystallization and melting of semicrystalline polymers with the aim of later modeling the residual stresses after processing in case where crystallization occurs in quasi static conditions (in additive manufacturing for example). Despite of an abundant literature on polymer crystallization, the current state of scientific knowledge does not yet allow ab initio modeling. Therefore, an alternative and pragmatic way has been explored to propose a first approximation of the impact of crystallization and melting on the storage and the loss moduli during crystallization-melting-crystallization cycle. An experimental approach, combining DSC, optical microscopy and oscillatory shear rheology was used to define macroscopic parameters related to the microstructure. These parameters have been integrated into a phenomenological model. Isothermal measurements were used to describe the general framework, and crystallization at a constant cooling rate was used to evaluate the feasibility of a general approach. It can be concluded that relying solely on the crystalline fraction is inadequate to model the rheology. Instead accounting for the microstructure at the spherulitic level could be more useful. Additionally, the results obtained from the experiments help to enhance our understanding of the correlations between crystallization kinetics and its mechanical effects.
Nutritional and Functional properties and Applications of Mee (Madhuca longifolia) seed fat
Authors: Hippola Asanthi , Jayakodi Yasasvi , Gamage Ashoka , Madhujith Terrence , Merah Othmane
Published: August 2023

Mee (Madhuca longifolia) is an important economic tree growing throughout the subtropical region of the Indo-Pak subcontinent. Mee seed constituents have distinctive chemical properties and thus provide nutritional and functional characteristics to the mee fat. The mee seed fat is an edible fat which can provide fat requirement of human diet in an economical way. Research on potential utilizations, understanding on the chemical composition, nutritional value and industrial applications of mee fat is important for efficient use mee seed fat. There were some reports available on potential applications of mee fat in food processing industry. But presently mee fat can be considered as an underutilized seed fat. In India mee fat used for edible purposes for a certain extent with compare to Sri Lanka. Therefore, more scientific researches should conduct on Sri Lankan mee varieties on edible purposes and popularized edible uses of Mee fat in Sri Lanka. Scientific knowledge and agricultural tools should effectively apply to make mee fat beneficial for its commercial applications. This chapter summarizes recent research work and studies available on botany, phytochemistry, functional properties, processing as well as food and non-food industrial applications of mee fat and other valuable parts of mee tree.
A Personalized Alert System for Air-quality Monitoring Based on Lung Functionality: An Observational Pilot Study
Authors: Alotaibi Mohammed , Alnajjar Fady , Alsayed Badr Abdulmohsin , Alhmiedat Tareq , Marie Ashraf , Bushnag Anas , Ali Luqman
Published: August 2023

Asthma is a chronic respiratory disease that impairs breathing. Management of asthma presents a significant challenge due to its inherent variability; that is, its symptoms can substantially differ among individuals, thereby complicating the prediction and management of exacerbations. Furthermore, individuals with asthma often have unique triggers that precipitate symptoms or attacks. The identification of these triggers can often prove to be a challenging, and at times, an impractical attempt. To address this, our research proposes a practical, personalized alert system, predicated on individual lung function tests conducted under varying environmental conditions classified by air-quality sensors. To validate this concept, we conducted an observational pilot study involving healthy individuals. We recruited twelve healthy participants and monitored their responses across a broad spectrum of environments, characterized by varying air quality, temperature, and humidity conditions. The lung function for each participant, assessed using peak expiratory flow (PEF) values, was recorded in each of these environments. Our results highlighted substantial variability in pulmonary responses to different environments. Utilizing these insights, we proposed a personalized alarm system that provides real-time air-quality monitoring and issues alerts when environmental conditions may potentially become unfavorable. We also explored the feasibility of employing basic machine learning techniques to predict PEF values in the aforementioned environmental conditions. This proposed system has the potential to empower individuals in actively safeguarding their respiratory health and mitigating discomfort caused by environmental conditions, especially in cases of asthma patients. By enabling timely and personalized interventions, the system aims to provide individuals with the necessary tools to minimize exposure to asthma’s possible triggers.
Synthesis and Assessment of a Polyurethane Carrier Used for the Transmembrane Transfer of 2'-Deoxycytidine-5'-monophosphate sodium salt
Authors: Borcan Florin , Vlase Titus , Vlase Gabriela , Popescu Roxana , Soica Codruta M
Published: August 2023

The drug delivery systems receive more and more attention for the control and treatment of many diseases due to their increased number in recent years. The main aims of this study were to develop and to characterize a polyurethane drug delivery system that it is intended to be used for the transmembrane transport of nucleosides. Three different samples have been synthesized based on aliphatic diisocyanates (hexamethylene diisocyanate, isophorone diisocyanate and lysine diisocyanate) as organic phase, respectively a mixture of polyethylene glycol, polycaprolactone diol and low molecular weight diols as aqueous phase. The samples were characterized by pH, refractivity index and solubility measurements, drug loading efficacy and release investigations, thermal behavior, Zetasizer, cells viability and irritation tests on mice skin. The results indicate the obtaining of different populations of neutral acido-basic particles with size between 132 and 190 nm; the Zeta potential values and SEM images show a medium tendency to form clusters, while UV-Vis evaluations indicate an almost 70% encapsulation efficacy, a prolonged release (45% of encapsulated substance is released in the first 5 days) and around 70% of particles have penetrated an artificial membrane in the first 24h. The synthesized products can be tested in further clinical trials, the currently tests on cells culture and mice skin revealing no side effects.