bluuebunny/crossref_metadata_2025 huggingface dataset:
Autologous peripheral blood stem cell mobilization and apheresis in pediatric patients with cancer: A single‐center report of 64 procedures
Authors: Yazal Erdem Arzu , Özyörük Derya , Ok Bozkaya İkbal , Çakmakcı Selma , Emir Suna , Demir Hacı Ahmet , Özgüner Habibe Meltem , Ergürhan İlhan İnci , Özbek Namık Yaşar
Published: April 2024

Background

The published experience concerning autologous peripheral blood stem cell collection in children is very limited.

Methods

The data of pediatric patients who underwent autologous stem cell mobilization and apheresis between January 2011 and April 2020 were analyzed retrospectively.

Results

We studied retrospectively 64 mobilization and apheresis procedures in 48 pediatric patients (34 males, 14 females), mean age of 7.31 ± 5.38 (range, 1.5–19.7) years, the underlying disease was mostly neuroblastoma (NBL). The body weight of 21 patients (43.75%) was 15 kg or less. The targeted autologous peripheral stem cell apheresis (APSCA) was successfully achieved in 98% of patients. Neuroblastoma patients were younger than the rest of the patients and underwent apheresis after receiving fewer chemotherapy cycles than others and all of them mobilized within the first session successfully. Plerixafor was added to mobilization in nine heavily pretreated patients (18.7%), median two doses (range, 1–4 doses). 11 patients (22.9%) underwent radiotherapy (RT) before mobilization with doses of median 24 Gy (range, 10.8–54.0 Gy). Patients with RT were older at the time of apheresis and had received more chemotherapy courses than patients without RT. As a result, patients with a history of RT had significantly lower peripheral CD34+ cells and CD34+ yields than those without RT. In 17 patients (35.4%), 22 different complications were noted. The most common complications were catheter‐related infections (n:10, 20.8%), followed by catheter‐related thrombosis in eight patients (16.7%).

Conclusions

Patients who had far less therapy before apheresis were more likely to mobilize successfully. Our study provides a detailed practice approach including complications during APSCA aiming to increase the success rates of apheresis in transplantation centers.
Nanoparticles‐based double‐stranded RNA delivery as an antiviral agent in shrimp aquaculture
Authors: Jonjaroen Veasarach , Charoonnart Patai , Jitrakorn Sarocha , Payongsri Panwajee , Surarit Rudee , Saksmerprome Vanvimon , Niamsiri Nuttawee
Published: April 2024

The review encapsulates the comprehensive exploration of RNA interference technology's application in shrimp aquaculture, covering molecular intricacies, production methods, and practical applications. The emphasis is on exploring the stability and delivery of gene‐specific double‐stranded RNA, particularly through nanoencapsulation. This is because the susceptibility of dsRNA to degradation and limited cellular penetration, emphasising the need for effective delivery mechanisms. The review presents an in‐depth exploration of nanoparticles for the encapsulation and delivery of dsRNA, including virus‐like particles (VLPs), and non‐viral based nanoparticles such as liposomes, chitosan, and beta‐glucan. VLPs, derived from non‐infectious shrimp virus structures, exhibit biocompatibility and natural functionality, making them suitable carriers for dsRNA. The application of chitosan and its derivatives are explored for their efficacy in reducing viral infections in shrimp. Beta‐glucan particles are examined for their immunostimulant properties in shrimp aquaculture. The text emphasises the use of yeast‐based glucan particles for encapsulating dsRNA, showcasing their potential in preventing viral diseases in shrimp. The review introduces cautionary considerations for nanoparticle formulation, highlighting factors such as pH, organic solvents, metal ions, and environmental ribonuclease that can impact dsRNA stability during synthesis. In conclusion, the text discusses the potential economic worthiness and environmental risk assessment of dsRNA technology in shrimp aquaculture. While acknowledging successful applications in other environments, it underscores the need for regulatory approval and risk assessment for dsRNA‐based products in the aquaculture industry. The evaluation of dsRNA in real‐world shrimp farms is deemed necessary for commercial utilisation, taking into account income, expenses, safety, and environmental considerations.
Asymptotic properties of resampling‐based processes for the average treatment effect in observational studies with competing risks
Authors: Rühl Jasmin , Friedrich Sarah
Published: April 2024

In observational studies with time‐to‐event outcomes, the g‐formula can be used to estimate a treatment effect in the presence of confounding factors. However, the asymptotic distribution of the corresponding stochastic process is complicated and thus not suitable for deriving confidence intervals or time‐simultaneous confidence bands for the average treatment effect. A common remedy are resampling‐based approximations, with Efron's nonparametric bootstrap being the standard tool in practice. We investigate the large sample properties of three different resampling approaches and prove their asymptotic validity in a setting with time‐to‐event data subject to competing risks. The usage of these approaches is demonstrated by an analysis of the effect of physical activity on the risk of knee replacement among patients with advanced knee osteoarthritis.
Ehlers–Danlos syndrome (cutaneous asthenia) in a Campbell's dwarf hamster (Phodopus campbelli)
Authors: Ciszewska‐Ceran Jagoda , Szczepanik Marcin , Wilkołek Piotr , Śmiech Anna , Wilczyńska Anna , Szadkowski Mateusz
Published: April 2024

A case of cutaneous asthenia in a Campbell's dwarf hamster is described. The animal was found to have hyperextensible skin, glaucoma and lens dislocation. Histopathological examination revealed an irregular, haphazard arrangement of collagen fibres in the dermis. The animal underwent surgical reduction of the skin folds which provided only temporary relief.
Effect of a Neuromodulation Protocol Associated With Sports Training on the Precision Sports Performance of a Wheelchair Basketball Para-Athlete: A Case Study
Authors: Oliveira Larissa S. , Aleixo Gabriel F. , Luvizutto Gustavo J. , Lobato Daniel F.M.
Published: April 2024

Objective: To investigate whether transcranial direct-current stimulation (tDCS) optimizes the performance of a wheelchair basketball player on precision tasks. Methods: A right-handed wheelchair basketball player (1.5 points functional class) with myelomeningocele (low lumbar level) participated in this case study. The tDCS neuromodulation protocol was applied throughout 10 interventions of 20 minutes with a current intensity of 2 mA, simultaneously with sport-specific training, 3 times a week for 4 weeks. Anodic stimulation was performed on the right cerebellar hemisphere (CB2) and cathodic stimulation in the left dorsolateral prefrontal cortex. A control participant was submitted to a sham-tDCS stimulation protocol for the same period. Functional performance was assessed before the intervention and after the 5th and 10th interventions using “pass accuracy,” “free-throw shooting,” and “spot shot” tests. Outcome measures were compared using percentage differences between preintervention, intermediate intervention, and postintervention values. Results: There was a gradual increase in the athlete’s total and average scores in all tests performed, with an overall improvement of 78% between the baseline and final assessments, while the control participant had an overall improvement of 6.5%. Conclusion: The tDCS protocol was effective in improving performance in precision activities in a wheelchair basketball player.
Interventions Based on Behavior Change Techniques to Encourage Physical Activity or Decrease Sedentary Behavior in Community-Dwelling Adults Aged 50–70: Systematic Review With Intervention Component Analysis
Authors: Ahmed Saima , Lazo Green Kimberly , McGarrigle Lisa , Money Annemarie , Pendleton Neil , Todd Chris
Published: April 2024

Increasing physical activity (PA) and/or decreasing sedentary behaviors is important in the delay and prevention of long-term conditions. PA can help maintain function and independence and decrease the need for hospitalization/institutionalization. Activity rates often decline in later life resulting in a need for interventions that encourage uptake and adherence through the use of Behavior Change Techniques (BCTs). We conducted a systematic review of the evidence for interventions that included BCTs in community-dwelling adults with a mean age of 50–70. The review followed PRISMA guidelines. The interventions were psychosocial, nonpharmacological, and noninvasive interventions utilizing components based on BCTs that evaluated change in PA and/or sedentary behavior. Intervention Component Analysis (ICA) was used to synthesize effectiveness of intervention components. Twelve randomized controlled trials were included in this review. The mean sample age was 50–64. Thirteen BCTs were used across all studies, and the most commonly used techniques were goals and planning, feedback and monitoring, and natural consequences. Seven intervention components linked with BCTs were found: personalized goal setting, tailored feedback from facilitators, on-site and postintervention support, education materials and resources, reinforcing change on behavior and attitudes, self-reported monitoring, and social connectedness. All components, except for social connectedness, were associated with improved health behavior and PA levels. The interventions that use BCTs have incorporated strategies that reinforce change in behavior and attitudes toward PA.
Expansive discovery of chemically diverse structured macrocyclic oligoamides
Authors: Salveson Patrick J. , Moyer Adam P. , Said Meerit Y. , Gӧkçe Gizem , Li Xinting , Kang Alex , Nguyen Hannah , Bera Asim K. , Levine Paul M. , Bhardwaj Gaurav , Baker David
Published: April 2024

Small macrocycles with four or fewer amino acids are among the most potent natural products known, but there is currently no way to systematically generate such compounds. We describe a computational method for identifying ordered macrocycles composed of alpha, beta, gamma, and 17 other amino acid backbone chemistries, which we used to predict 14.9 million closed cycles composed of >42,000 monomer combinations. We chemically synthesized 18 macrocycles predicted to adopt single low-energy states and determined their x-ray or nuclear magnetic resonance structures; 15 of these were very close to the design models. We illustrate the therapeutic potential of these macrocycle designs by developing selective inhibitors of three protein targets of current interest. By opening up a vast space of readily synthesizable drug-like macrocycles, our results should considerably enhance structure-based drug design.
Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells
Authors: Offensperger Fabian , Tin Gary , Duran-Frigola Miquel , Hahn Elisa , Dobner Sarah , Ende Christopher W. am , Strohbach Joseph W. , Rukavina Andrea , Brennsteiner Vincenth , Ogilvie Kevin , Marella Nara , Kladnik Katharina , Ciuffa Rodolfo , Majmudar Jaimeen D. , Field S. Denise , Bensimon Ariel , Ferrari Luca , Ferrada Evandro , Ng Amanda , Zhang Zhechun , Degliesposti Gianluca , Boeszoermenyi Andras , Martens Sascha , Stanton Robert , Müller André C. , Hannich J. Thomas , Hepworth David , Superti-Furga Giulio , Kubicek Stefan , Schenone Monica , Winter Georg E.
Published: April 2024

Chemical modulation of proteins enables a mechanistic understanding of biology and represents the foundation of most therapeutics. However, despite decades of research, 80% of the human proteome lacks functional ligands. Chemical proteomics has advanced fragment-based ligand discovery toward cellular systems, but throughput limitations have stymied the scalable identification of fragment-protein interactions. We report proteome-wide maps of protein-binding propensity for 407 structurally diverse small-molecule fragments. We verified that identified interactions can be advanced to active chemical probes of E3 ubiquitin ligases, transporters, and kinases. Integrating machine learning binary classifiers further enabled interpretable predictions of fragment behavior in cells. The resulting resource of fragment-protein interactions and predictive models will help to elucidate principles of molecular recognition and expedite ligand discovery efforts for hitherto undrugged proteins.
Cleavage-independent activation of ancient eukaryotic gasdermins and structural mechanisms
Authors: Li Yueyue , Hou Yanjie , Sun Qi , Zeng Huan , Meng Fanyi , Tian Xiang , He Qun , Shao Feng , Ding Jingjin
Published: April 2024

Gasdermins (GSDMs) are pore-forming proteins that execute pyroptosis for immune defense. GSDMs are two-domain proteins activated by proteolytic removal of the inhibitory domain. In this work, we report two types of cleavage-independent GSDM activation. First,
Tricho
GSDM, a pore-forming domain–only protein from the basal metazoan
Trichoplax adhaerens
, is a disulfides-linked autoinhibited dimer activated by reduction of the disulfides. The cryo–electron microscopy (cryo-EM) structure illustrates the assembly mechanism for the 44-mer
Tricho
GSDM pore. Second, RCD-1-1 and RCD-1-2, encoded by the polymorphic
regulator of cell death–1
(
rcd-1
) gene in filamentous fungus
Neurospora crassa
, are also pore-forming domain–only GSDMs. RCD-1-1 and RCD-1-2, when encountering each other, form pores and cause pyroptosis, underlying allorecognition in
Neurospora
. The cryo-EM structure reveals a pore of 11 RCD-1-1/RCD-1-2 heterodimers and a heterodimerization-triggered pore assembly mechanism. This study shows mechanistic diversities in GSDM activation and indicates versatile functions of GSDMs.
Kill wolves to save caribou? Sadly, it seems to work
Authors: Cornwall Warren
Published: April 2024

Some worry the findings will stall efforts to halt logging—the root cause of caribou population declines
Precision synbiotics increase gut microbiome diversity and improve gastrointestinal symptoms in a pilot open-label study for autism spectrum disorder
Authors: Phan Joann , Calvo Diana C. , Nair Divya , Jain Suneer , Montagne Thibaut , Dietsche Summer , Blanchard Kelsey , Treadwell Shirin , Adams James , Krajmalnik-Brown Rosa
Published: April 2024

The efficacy of prebiotics and probiotics (synbiotics when combined) to improve symptoms associated with autism spectrum disorder (ASD) has shown considerable inter-study variation, likely due to the complex, heterogeneous nature of the disorder and its associated behavioral, developmental, and gastrointestinal symptoms. Here, we present a precision synbiotic supplementation study in 296 children and adults diagnosed with ASD versus 123 age-matched neurotypical controls. One hundred seventy ASD participants completed the study. Baseline and post-synbiotic assessment of ASD and gastrointestinal (GI) symptoms and deep metagenomic sequencing were performed. Within the ASD cohort, there were significant differences in microbes between subpopulations based on the social responsiveness scale (SRS2) survey (
Prevotella
spp.
, Bacteroides, Fusicatenibacter
, and others) and gluten and dairy-free diets (
Bifidobacterium
spp.,
Lactococcus, Streptococcus
spp., and others). At the baseline, the ASD cohort maintained a lower taxonomic alpha diversity and significant differences in taxonomic composition, metabolic pathways, and gene families, with a greater proportion of potential pathogens, including
Shigella, Klebsiella,
and
Clostridium,
and lower proportions of beneficial microbes, including
Faecalibacterium
compared to controls. Following the 3-month synbiotic supplementation, the ASD cohort showed increased taxonomic alpha diversity, shifts in taxonomy and metabolic pathway potential, and improvements in some ASD-related symptoms, including a significant reduction in GI discomfort and overall improved language, comprehension, cognition, thinking, and speech. However, the open-label study design may include some placebo effects. In summary, we found that precision synbiotics modulated the gut microbiome and could be used as supplementation to improve gastrointestinal and ASD-related symptoms.

IMPORTANCE

Autism spectrum disorder (ASD) is prevalent in 1 out of 36 children in the United States and contributes to health, financial, and psychological burdens. Attempts to identify a gut microbiome signature of ASD have produced varied results. The limited pre-clinical and clinical population sizes have hampered the success of these trials. To understand the microbiome associated with ASD, we employed whole metagenomic shotgun sequencing to classify microbial composition and genetic functional potential. Despite being one of the most extensive ASD post-synbiotic assessment studies, the results highlight the complexity of performing such a case–control supplementation study in this population and the potential for a future therapeutic approach in ASD.
Aetiology and predictors of major bleeding events in patients with heart failure with reduced ejection fraction undergoing percutaneous coronary intervention
Authors: Iyer Meghana , Shah Rohan , Zheng Weili , Ziada Khaled M , Khot Umesh , Krishnaswamy Amar , Kapadia Samir R , Reed Grant W
Published: April 2024

Objectives

We sought to determine the relationship between the degree of left ventricular ejection fraction (LVEF) impairment and the frequency and type of bleeding events after percutaneous coronary intervention (PCI).

Design

This was an observational retrospective cohort analysis. Patients who underwent PCI from 2009 to 2017 were identified from our institutional National Cardiovascular Disease Registry (NCDR) CathPCI database. Patients were stratified by pre-PCI LVEF: preserved (≥50%), mildly reduced (41%–49%) and reduced (≤40%) LVEF.

Primary outcome measures

The outcome was major bleeding, defined by NCDR criteria. Events were classified based on bleeding aetiology and analysed by multivariable logistic regression.

Results

Among 13 537 PCIs, there were 817 bleeding events (6%). The rate of bleeding due to any cause, blood transfusion, gastrointestinal bleeding and coronary artery perforation or tamponade each increased in a stepwise fashion comparing preserved, mildly reduced and reduced LVEF reduction (p<0.05 for all comparisons). However, there were no differences in bleeding due to asymptomatic drops in haemoglobin, access site haematoma or retroperitoneal bleeding. After multivariable adjustment, mildly reduced and reduced LVEF remained independent predictors of bleeding events (OR 1.36, 95% CI 1.06 to 1.74, p<0.05 and OR 1.73, 95% CI 1.45 to 2.06, p<0.0001).

Conclusions

The degree of LV dysfunction is an independent predictor of post-PCI major bleeding events. Patients with mildly reduced or reduced LVEF are at greatest risk of post-PCI bleeding, driven by an increased need for blood transfusion, major GI bleeding events and coronary artery perforation or tamponade. Pre-PCI LV dysfunction does not predict asymptomatic declines in haemoglobin, access site haematoma or retroperitoneal bleeding.
Management practices benefit endangered Poweshiek skipperling (Oarisma poweshiek) in Manitoba tall grass prairie
Authors: Knight Samantha M. , Bleho Barbara I. , Grantham Melissa A. , Westwood Richard , Koper Nicola , Hamel Cary D.
Published: April 2024

Poweshiek skipperling ( Oarisma poweshiek Parker, 1870) populations have declined precipitously in the past few decades, and their global range is now restricted to two isolated regions, one of which is the managed Manitoba tall grass prairie in Canada. In this paper, we used a decade of survey data from 2010 to 2019 to understand how habitat features, management practices, and extreme weather impact Poweshiek skipperling abundance in Manitoba. The strongest predictor of abundance was the density of black-eyed Susans ( Rudbeckia hirta L.), a primary nectar plant for adults. Poweshiek skipperling abundance also had a negative relationship with both the number of years since a burn occurred and the number of years since grazing occurred. Cumulative precipitation during their active period (May–June) had a negative relationship with skipperling abundance, whereas warm early springs and cool temperatures during the active period had positive relationships. These results suggest that management actions that maintain tall grass prairie habitat in an early successional stage (burning and grazing) and maintain important nectar sources benefit this population. In contrast, extreme weather events had varying effects on Poweshiek skipperling abundance. Results from this study inform ongoing management practices in the Manitoba tall grass prairie to support this endangered population.
Some compactly supported dual wavelets associated to the Quincunx matrix in ℝ3
Authors: Arenas-Blázquez M. L. , San Antolín A.
Published: April 2024

In this paper, we construct a family of compactly supported dual wavelets associated to the Quincunx matrix on [Formula: see text]. Our family will have dual wavelets with any desired number of vanishing moments, any fixed degree of regularity and symmetry with respect to some point. Finally, we also present dual wavelets on [Formula: see text] associated to some dilation matrices with determinant [Formula: see text].
Half-Metallic Ferromagnetism in TM-Doped GaN Nanosheet — A Potential Candidate for Spintronics Device Application
Authors: Arif Ismayilova Narmin , Prakash Rai Dibya
Published: April 2024

Density functional theory (DFT) analyses were carried out to study electronic structures and magnetic properties of Mn- and Cu-doped GaNNS. To investigate the influence of transition metal atoms (TM) on magnetic properties, we substituted Ga atoms with Mn and Cu atoms in different concentrations. Investigation shows that TM leads to electronic structural reconstruction which changes their properties in this way, and plays a significant role in spin polarization. Although the pure nanosheet is a nonmagnetic semiconductor, the doped atoms induce magnetism in the structure. The band gap changes monotonically depending on the concentration of TM atoms. The observed good half-metal ferromagnetism GaNNS:Mn, allows them to be a potential candidate for use in spintronics. The local magnetic moment calculated from Mulliken analyses for the Mn atom is approximately 4.05 [Formula: see text]B.
Seismic Resistance and Performance Evaluation of Masonry Dwellings After the February 6, 2023, Kahramanmaraş Earthquake Sequence in Türkiye
Authors: Onat Onur , Yön Burak , Uslu Ali , Öncü Mehmet Emin , Varolgüneş Sadık , Karaşin İbrahim Baran , Gör Mesut
Published: April 2024

On February 6, 2023, two catastrophic earthquakes occurred on the East Anatolian Fault. The earthquakes had magnitudes of Mw = 7.7 and 7.6 and struck Kahramanmaraş-Pazarcık and Kahramanmaraş-Elbistan, respectively. The Kahramanmaraş-Pazarcık earthquake was triggered at 04:17 local time on the Dead Sea Fault (a branch of the East Anatolian Fault). The last earthquake on the addressed fault occurred about 500 years ago. The recorded peak ground acceleration (PGA) at the Pazarcık station reached 2.05g. In addition, the Pazarcık earthquake triggered two independent earthquakes, the Nurdağı and Islahiye earthquakes, which occurred 10 min later than the Pazarcık earthquake. However, the last earthquake, with its epicenter in Kahramanmaraş-Elbistan, struck at 13:24 local time. The recorded PGA for the Elbistan earthquake is 0.68g. This study aims to present the fault rupture mechanism of the February 6, 2023, Kahramanmaraş earthquakes, earthquake characteristics, and to evaluate the performance of masonry dwellings during the Kahramanmaraş earthquake doublet, which affected 10 provinces and numerous towns and villages. This paper also aims to illustrate the damage and failure mechanisms of the masonry dwellings, despite unexpectedly high accelerations that exceeded the design spectrum in the field, specifically in Kahramanmaraş, Gaziantep, Hatay, and Malatya, according to the current earthquake code in use.
Contracting boundary of a cusped space
Authors: Pal Abhijit , Pandey Rahul
Published: April 2024

Let [Formula: see text] be a finitely generated group. Cashen and Mackay proved that if the contracting boundary of [Formula: see text] with the topology of fellow traveling quasi-geodesics is compact then [Formula: see text] is a hyperbolic group. Let [Formula: see text] be a finite collection of finitely generated infinite index subgroups of [Formula: see text]. Let [Formula: see text] be the cusped space obtained by attaching combinatorial horoballs to each left coset of elements of [Formula: see text]. In this article, we prove that if the combinatorial horoballs are contracting and [Formula: see text] has compact contracting boundary then [Formula: see text] is hyperbolic relative to [Formula: see text].
Exploiting the Digital Economy for Product Realization in Manufacturing
Authors: Witherell Paul , Kumara Soundar
Published: April 2024

In this paper, we briefly discuss the evolving concepts of the digital economy, digital threads, and product realization (manufacturing) in the digital economy-enabled futuristic world. We posit that if we need to become self-sufficient, it is imperative that small and medium manufacturing enterprises need to be equitably integrated into the digital economy. We lead this discussion to the most important research questions related to representation, search, and composition to achieve such a realization.
Steam Condensation Heat Transfer in the Presence of Noncondensable Gases (NCGs) in Nuclear Power Plants (NPPs): A Comprehensive Review of Fundamentals, Current Status, and Prospects for Future Research
Authors: Albdour Samah A. , Addad Yacine , Alyammahi Nourah , Afgan Imran
Published: April 2024

Efficient steam condensation is crucial for safe nuclear power plant (NPP) operations, preventing pressure buildup, overheating, and the release of radioactive materials. However, the presence of noncondensable gases (NCGs), such as air, nitrogen, hydrogen, or helium, can hinder the condensation process by creating a thermal resistance layer that impedes steam diffusion and condensation on the system’s surface. Maximizing the efficiency of steam condensation requires a thorough grasp of the fundamental processes, theories, advancements, and technical hurdles. Therefore, this work thoroughly addresses these needs, with a particular emphasis on addressing the challenges posed by NCGs by dividing the work into four thematic areas. The first theme relates to a comprehensive examination of pure steam condensation phenomena, which includes an exploration of familiar condensation scenarios and various film condensation types. The second theme examines condensation in the presence of NCGs, their mixture properties, and related theories and modelling of heat and mass transfer. The third theme investigates condensation in NPP by exploring passive cooling systems and condensation phenomena under both natural and forced convection conditions during nuclear accidents, the origin of NCGs in NPP and their transportation aspects. This is followed by experimental work related to condensation scenarios and scale. Finally, the last theme looks upon the recent advancements in computational fluid dynamics (CFD) modelling of wall condensation, system analysis codes coupling with CFD, and the implementation of machine learning (ML) for predicting the condensation HTC. By bridging the gap between fundamental knowledge and practical applications, the four thematic areas presented in this work are aimed at providing a comprehensive foundation for researchers and experts in the field of steam condensation when NCGs are involved. The ultimate objective is to bolster the safety and efficacy of NPP operations by understanding the heat and mass transfer mechanisms while mitigating the risk of catastrophic events.
Exploring the Potential Consortium of Migraine and Periodontitis
Authors: Ponnaiyan Deepa , Rughwani Roshan R. , Shetty Ganesh , Mahendra Jaideep , Victor Dhayanand John , Thakare Kaustubh Suresh , Reddy N. Sowmya
Published: April 2024

Objectives. Various researches have shown periodontitis to share common pathophysiological pathways with systemic diseases such as diabetes, cardiovascular diseases, and osteoporosis and recently neurological disorders. This article provides a narrative review summarizing the various linking mechanisms and the nature of association between two multifactorial diseases—periodontitis and migraine. Materials and Methods. A literature search was performed for articles related to periodontitis and migraine up till the year 2023 which yielded totally 14 articles. There were only three randomized controlled clinical trials; therefore, we were unable to conduct a systematic review and focused on a narrative review. The keywords searched were “migraine”, “periodontitis” and “biomarkers” in PubMed/Medline, Web of Science, and Embase databases. Any article related to the association of periodontitis and migraine and the dental management of subjects with headache disorders were included and studies with migraine and other dental diseases were excluded. Results. It is found that the occurrence of periodontitis and migraine are associated with each other. There is reasonable evidence to believe that periodontitis and migraine are linked by direct and indirect mechanisms which can eventually lead to chronic inflammatory conditions like periodontitis worsening neurovascular conditions such as migraine. However, upon detailed analysis it was found that the strength of association is weak owing to the presences of various common confounding and risk factors. Conclusions. The association between periodontitis and migraine cannot be denied, however, not all the criteria are fulfilled while examining the nature of association and future long‐term studies are required to prove the same. Clinical Relevance. Various studies have reported poor periodontal health in patients with migraine. The risk of exacerbation of migraine also increases in subject undergoing dental therapy if the triggering factors are manipulated. Hence, knowing the precise pathophysiologic mechanisms linking both the diseases would be favorable in planning treatment protocols for subjects with migraine.
A Condition Monitoring Method of Hydraulic Gear Pumps Based on Multilevel Mechanism-Data Fusion
Authors: Ren Linlin , Ma Hongbo , Zhou Wen , Huang Shuhan , Wu Xueying
Published: April 2024

Pumps are important components in aviation fuel hydraulic systems, and thanks to the development of sensor technology and industrial intelligence technology, it is possible to achieve efficient state monitoring of pumps. However, when data quality is poor or the amount of data is small, a single data-driven model may not be able to meet diagnostic accuracy. A condition monitoring method for hydraulic gear pumps based on mechanism-data fusion is proposed. The method combines a mechanism model based on the volumetric efficiency formula with a data-driven model based on vibration signals. First, the parameters of volumetric efficiency are solved by fitting the pressure–flow relationship. Subsequently, a multichannel fusion and multikernel function-weighted ensemble support vector classification (MCMK-SVC) is developed, to establish a data-driven model. Finally, through data-level fusion, feature-level fusion, and decision-level fusion, a condition monitoring model based on mechanism-data fusion is built. Experimental verification shows that the accuracy of the three levels of fusion models exceeds 96.9%. Compared to the single data-driven model or other traditional data-driven models, the accuracy of the proposed method has improved by 3% to 33%, demonstrating the effectiveness of the mechanism-data fusion model.
Vibration Properties of Submerged Sandwich Cylindrical Shell Based on Wave Propagation Approach: Analytical and Experimental Investigation
Authors: Guo Guoqiang , Zhao Yinglong , Yu Anbin
Published: April 2024

The vibration properties of the submerged sandwich cylindrical shell with a viscoelastic core are investigated in this paper. Considering the acoustic‐structure coupling, the analytical model of the submerged sandwich cylindrical shell that can handle three medium conditions including fluid‐filled, fluid‐loaded, and fluid‐filled and ‐loaded is derived based on the wave propagation approach and the Flügge thin‐shell theory. The vibration properties of the sandwich cylindrical shell under different medium and boundary conditions are analyzed, followed by a comparison of the damping effect of the constrained damping layer. Finally, an analysis is conducted on the influence of thicknesses of viscoelastic and constrained layers on vibration spectrum and natural frequency under fluid‐filled and ‐loaded conditions. An experimental platform was established to conduct relevant experiments. Several important conclusions can be drawn.
TABLE 1 from Impact of Surgery-Induced Myeloid-derived Suppressor Cells and the NOX2/ROS Axis on Postoperative Survival in Human Pancreatic Cancer
Authors: Grauers Wiktorin Hanna , Aydin Ebru , Kiffin Roberta , Vilhav Caroline , Bourghardt Fagman Johan , Kaya Mustafa , Paul Sanchari , Westman Beatrice , Bratlie Svein Olav , Naredi Peter , Hellstrand Kristoffer , Martner Anna
Published: April 2024

Patient characteristics and their impact on survival
Figure S5 from Impact of Surgery-Induced Myeloid-derived Suppressor Cells and the NOX2/ROS Axis on Postoperative Survival in Human Pancreatic Cancer
Authors: Grauers Wiktorin Hanna , Aydin Ebru , Kiffin Roberta , Vilhav Caroline , Bourghardt Fagman Johan , Kaya Mustafa , Paul Sanchari , Westman Beatrice , Bratlie Svein Olav , Naredi Peter , Hellstrand Kristoffer , Martner Anna
Published: April 2024

DC frequences and DC marker expression before and after surgery
Figure S1 from Impact of Surgery-Induced Myeloid-derived Suppressor Cells and the NOX2/ROS Axis on Postoperative Survival in Human Pancreatic Cancer
Authors: Grauers Wiktorin Hanna , Aydin Ebru , Kiffin Roberta , Vilhav Caroline , Bourghardt Fagman Johan , Kaya Mustafa , Paul Sanchari , Westman Beatrice , Bratlie Svein Olav , Naredi Peter , Hellstrand Kristoffer , Martner Anna
Published: April 2024

Levels of cytokines in plasma before and after pancreatic cancer surgery
FIGURE 4 from Impact of Surgery-Induced Myeloid-derived Suppressor Cells and the NOX2/ROS Axis on Postoperative Survival in Human Pancreatic Cancer
Authors: Grauers Wiktorin Hanna , Aydin Ebru , Kiffin Roberta , Vilhav Caroline , Bourghardt Fagman Johan , Kaya Mustafa , Paul Sanchari , Westman Beatrice , Bratlie Svein Olav , Naredi Peter , Hellstrand Kristoffer , Martner Anna
Published: April 2024

M-MDSC suppress NK cells by generating ROS and show enhanced NK cell suppression after surgery. A–C, NK cells were co-cultured with or without PANC-1 cells and freshly isolated healthy donor (HD) monocytes in the presence or absence of 100 µmol/L HDC, 200 U/mL catalase (Cat), 10 µmol/L GSK2795039 (GSK) or 1% DMSO (control). NK cell activation and degranulation were measured by flow cytometry and are shown by frequencies of NK cells expressing CD69+CD16+ (A) or CD107a+CD16+ (B), respectively. C, NK cell cytotoxicity against PANC-1 cells was determined by frequency of LIVE/DEAD stained PANC-1 cells. NK cell cytotoxicity against PANC-1 cells was measured in four independent experiments, that each included two to three combinations of NK cells and monocyte from different donors. D, ROS formation was measured by CL from CD33+ cells isolated 3–5 days after surgery in the absence of stimulation (PDAC Ctrl, orange), in the presence of rituximab (PDAC RTX, red), in the presence of rituximab and HDC (PDAC RTX + HDC, green) and from 2 HDs stimulated with rituximab (mean ROS formation shown, HD RTX, black). NK cells were cocultured with K562 cells and CD33+ cells isolated from HDs or patients before surgery (pre-op) or 3–5 days after surgery (days 3–5) in the presence (HDC) or absence of HDC. NK cell activation and degranulation were measured by flow cytometry as frequencies of CD16+ NK cells expressing CD69 (E) or CD107a (F) in NK:K562:Myeloid cell cocultures. NK cell cytotoxicity was measured in 10 independent experiments that were normalized by setting the mean NK cell cytotoxicity against K562 in the absence of myeloid cells to 1 in each experiment. Statistics by mixed-effects analysis followed by Šídák multiple comparison test (P-values indicated by *). HD and cancer samples were compared using Kruskal–Wallis test followed by Dunn multiple comparison test (P-values indicated by #).*, P < 0.05; **/##, P < 0.01; ***, P < 0.001; ****, P < 0.0001.
FIGURE 1 from Impact of Surgery-Induced Myeloid-derived Suppressor Cells and the NOX2/ROS Axis on Postoperative Survival in Human Pancreatic Cancer
Authors: Grauers Wiktorin Hanna , Aydin Ebru , Kiffin Roberta , Vilhav Caroline , Bourghardt Fagman Johan , Kaya Mustafa , Paul Sanchari , Westman Beatrice , Bratlie Svein Olav , Naredi Peter , Hellstrand Kristoffer , Martner Anna
Published: April 2024

Pancreatic cancer surgery triggers inflammation and expansion of M-MDSC. A, Flow chart of included IPEP study participants. B, Study design and available samples. Absolute numbers of neutrophils (C), monocytes (D), and lymphocytes (E) in patients undergoing surgery for periampullary cancer with whole blood samples (differential counts) analyzed before (pre-op) and 1, 3–5 and 28 days after pancreatic cancer surgery (day 1, days 3–5, and day 28, respectively; N = 17 for pre-op, N = 16 for day 1, N = 15 for days 3–5, N = 11 for day 28). F, Plasma levels of IL6 in healthy donors (HD) and in pre- and post-op samples from patients (N = 16 for pre-op and for day 1, N = 15 for days 3–5, N = 9 for day 28, N = 6 for HD). G–I, CD14+HLADRlow M-MDSC in peripheral blood of healthy donors and patients before and after surgery analyzed by flow cytometry. G, Representative FACS plot of the frequency of CD14+HLADRlow cells among CD14+ cells. Absolute numbers (H) and frequencies (I) of M-MDSC (N = 17 for pre-op, N = 16 for day 1 and days 3–5, N = 10 for day 28, N = 12 for HD). J, M-MDSC levels of ROS as measured by DCFDA MFI (N = 16 for pre-op, for day 1 and for days 3–5, N = 10 for day 28, N = 12 for HD). Preoperative and postoperative samples were compared using mixed-effects analysis followed by Šídák multiple comparison test (P-values indicated by *). HD and cancer samples were compared using Kruskal–Wallis test followed by Dunn multiple comparison test (P-values indicated by #). */#P < 0.05, ##P < 0.01, ***/###P < 0.001, ****/####P < 0.0001.
Caracterización de la literacidad en adolescentes y jóvenes privados de la libertad
Authors: Arbeláez-Gómez Martha Cecilia , Machado-Mena Karen Hasleidy
Published: April 2024

(analytical)Literacy involves language practices that impact the construction of identity and citizen education. This vision is particularly challenging for adolescents and young people detained in the Adolescent Criminal Responsibility System (SRPA) in Colombia. The research described in this article is uses a mixed-methodology approach. The initial pre-test result is presented, which measures the level of literacy among participants. The main findings of the study evidence that the adolescents and young people detained in the SRPA have difficulties with reading comprehension and writing. These practices are alien to their forms of communicating and expresing their dreams, interests, fears and interpretations of the world.
Navigating the U.S.–China Decoupling: Malaysia's Response to the U.S.–China Trade War
Authors: Kam Andrew Jia-Yi
Published: April 2024

This paper examines the impact of the current U.S.–China trade war on Malaysia. Malaysia's neutral stance leaves possibilities open for trade and investments from both sides. Our survey shows that the negative impacts have been minimal so far. The country seeks to capitalize on the trade war by promoting local industries that are substitutable to those from the United States and China. Efforts to improve competitiveness by improving physical and digital infrastructure, facilitating small- and medium-sized enterprises to export, and promoting potential domestic suppliers are being made to ensure favorable conditions to receive foreign direct investment relocating from China or the United States. Malaysia is also cooperating with its regional partners to further mitigate the effects of the trade war. Malaysia may, however, be its own greatest enemy in capitalizing from the trade war because the decline in human capital is making it difficult to harness the benefits from upcoming deglobalization headwinds.
The Determining Role of Covariances in Large Networks of Stochastic Neurons
Authors: Painchaud Vincent , Desrosiers Patrick , Doyon Nicolas
Published: April 2024

Biological neural networks are notoriously hard to model due to their stochastic behavior and high dimensionality. We tackle this problem by constructing a dynamical model of both the expectations and covariances of the fractions of active and refractory neurons in the network’s populations. We do so by describing the evolution of the states of individual neurons with a continuous-time Markov chain, from which we formally derive a low-dimensional dynamical system. This is done by solving a moment closure problem in a way that is compatible with the nonlinearity and boundedness of the activation function. Our dynamical system captures the behavior of the high-dimensional stochastic model even in cases where the mean-field approximation fails to do so. Taking into account the second-order moments modifies the solutions that would be obtained with the mean-field approximation and can lead to the appearance or disappearance of fixed points and limit cycles. We moreover perform numerical experiments where the mean-field approximation leads to periodically oscillating solutions, while the solutions of the second-order model can be interpreted as an average taken over many realizations of the stochastic model. Altogether, our results highlight the importance of including higher moments when studying stochastic networks and deepen our understanding of correlated neuronal activity.
Idealism and Edwards the Preacher
Authors: Njoto Ricky F.
Published: April 2024

Jonathan Edwards’s idealism did not seem to leave any place for material things or acts beyond mere ideas and perceptions. So, why was he so serious and faithful in his role as a preacher if the act of preaching in the material world did not have any existence beyond perception? This essay suggests that the preaching of the Word had a significant place in Edwards’s idealism because of his reconception of the theologies of sin, faith, and preaching in new metaphysical and relational terms that allowed him to place such theologies in his idealism.
Relying on Runaways
Authors: Kaelin Kelly
Published: April 2024

In her 1772 memoir, Sarah Chapman relays an exciting tale of daring escape from her parent’s home in December 1752. She was seventeen, single, and determined to join the Moravian Church, a new group originating in eastern Saxony. Women like Sarah—usually young and single—saw in the Moravians an alternative to settled life. This article explores the place of the Moravian Church as a disruptive organization which built congregations of young people who separated themselves from home and family, often dramatically retold in spiritual memoirs. Their Hussite proto-Reformation influences, combined with the charismatic leadership of the Saxon Count Zinzendorf, provided space for diverse forms of female participation. Through tales of run-away women, I argue that studying Moravian women disrupts the traditional conception of church creation as predominantly male and instead reconceives the religious fracturing of eighteenth-century Protestantism as something intimately experienced by women, even those young and single.
Responding to the COVID-19 Care Home Crisis
Authors: Ó Fathaigh Cillian
Published: April 2024

This article attends to Beauvoir’s concept of the image in The Coming of Age, Les Belles Images, and A Walk through the Land of Old Age. The author argues that the experience of being an older adult emerges primarily from the available social images of old age rather than from the aging body. This view reveals problems with the discourse around older people that fueled the COVID-19 care home crisis and that persist in our response to the crisis.
Self-Translation and Comics: Practices, Attitudes, and Publishing
Authors: Van Dijk Floriane
Published: April 2024

This article is the first attempt to identify comics self-translators and analyze their practices, taking into account the multimodality of the medium. Based on this corpus of comics authors who have translated their own work, this article addresses the contexts (sedentary or migratory) in which they work, the languages they use, and the way they publish their works. It discusses the attitudes that comics self-translators have toward self-translation, especially in terms of their own perceived freedom, before analyzing the authors’ translation choices, while considering how authors collaborate with other parties, including the illustrators. Finally, attention is paid to the publishing choices, including avenues, timelines, and editing choices related to the comic book covers. These reflections open a new topic of research around the specificities of self-translated comics and of comics self-translators themselves.
Nonnormative Self-Translation and Code-Switching in Argentina ’s New Feminist and Queer Poetry
Authors: Stocco Melisa
Published: April 2024

This article examines the poetry of feminist writer Dolo Trenzadora (b. 1985, Buenos Aires) and queer author Franco Rivero (b. 1981, Corrientes), two new voices in Argentine poetry who write in both Spanish and Guarani and reflect multilingual experiences emerging against the backdrop of a monolingual imaginary of nationhood. The analysis seeks to identify, within these writers’ most recent works, particular forms of “fragmentary intratextual self-translation” and to observe how, along with code-switching, these expressions of self-translation: (1) develop a nonnormative heterolingual discourse that defies monolingualism and troubles notions of national, gender, and sexual identity; and (2) resist monolingual models of Translation Studies.
In the Vanguard of the 1930s Reformed Resurgence
Authors: Stewart Kenneth J.
Published: April 2024

The first two decades of the twenty-first century have manifested a large-scale revival of interest in John Calvin, Reformed Theology and popular forms of Calvinism. Journalists have scrambled to grasp the parentage of a movement which had so long been out of the public view. Sympathetic Christian writers have developed a range of hypotheses about the roots of this resurgence, with most concentrating on developments unfolding since the mid-twentieth century. This essay maintains that the actual roots of the contemporary Calvinist resurgence lie in the period following the Great War (1914–1918), when three distinguishable streams of Protestant thought found common ground and for a period of at least a quarter-century collaborated to draw attention to the resources offered in the broadly Reformed theological tradition.
Revision of the genus Deroplatys Westwood, 1839 (Mantodea: Deroplatyidae) with the description of three new species
Authors: ZHANG JIA-ZHI , PRICE BENJAMIN
Published: April 2024

A morphological review of the mantid genus Deroplatys Westwood, 1893 is presented. The type specimens of Deroplatys desiccata Westwood, 1839, D. trigonodera Westwood, 1889 and D. rhombica De Haan, 1842 are illustrated. The holotype of D. angustata Westwood, 1841 has been rediscovered in the NHM collection and the description of the external morphology and male genitalia are provided. Deroplatys horrifica Westwood, 1889 is now a new synonym of D. lobata (Guérin-Méneville, 1838). Three new species namely Deroplatys kinabaluensis sp. nov., Deroplatys nebula sp. nov. and Deroplatys xuzhengfai sp. nov. are described and illustrated. New identification keys were generated for both sexes. The distribution of the genus Deroplatys species is discussed and mapped.