bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Ethanol Solution Concentration in the Extraction Process of Centella asiatica L. Bioactive Components Using Microwave-Assisted Extraction (MAE) Method
Authors: Fira Ulvatur Rohmaha  , Rina Auliyah Safitri  , Ayu Ulum Rahmawati  , Atiqa Rahmawati
Published: March 2023

The Pegagan plant has a scientific name in the form of Centella asiatica L. which is included in the Centella genus, Apiaceae family, and kingdom Plantae. Pegagan (Centella asiatica L.) has distinctive bioactive components, namely triterpene ester glycoside compounds in the form of asiaticoside and madecassoside, and triterpene group compounds in the form of Asiatic acid and madecassic acid. In this study, the extraction of bioactive components from pegagan was carried out using the Microwave-Assisted Extraction (MAE) method and will study the effect of ethanol solvent concentration in the extraction of bioactive compounds. Analysis of the extracted bioactive content was carried out by analyzing the total phenol content using the Folin-Ciocalteau reagent and ANOVA analysis. The results obtained from the study were in the form of total phenol content as an indication of the presence of bioactive compounds, namely at operating conditions of 450 watts of power, 50% ethanol concentration with a radiation time of 15 minutes which resulted in a total phenol content of 21.9244 mg AGE/g sample. In the ANOVA analysis with ethanol solvent, variables that gave a significant response to the total phenol content were microwave power, radiation time, and ethanol concentration with an R-square value of 95.31%. The effect of ethanol concentration on the total phenol content produced, namely the concentration of pure ethanol solvent will produce extracts with the smallest total phenol content, the effect of extraction time on total phenol content, namely the longer extraction time will increase the total phenol content. Maximum total phenol content using ethanol solvent that is, at operating conditions of 450 watts of power, 10% ethanol concentration with a radiation time of 15 minutes which resulted in a total phenol content of 520 mg AGE/g sample.
Praktyka stosowania i wykładni art. 99 ust. 3 ustawy Prawo farmaceutyczne — glosa do wyroku WSA w Warszawie z 2 sierpnia 2022 roku, V SA/Wa 4749/21
Authors: Jabłoński Mariusz , Jarosz-Żukowska Sylwia
Published: March 2023

Przedmiotem opracowania jest krytyczna ocena stanowiska wyrażonego przez Wojewódzki Sąd Administracyjny w wyroku z 2 sierpnia 2022 roku, V SA/Wa 4749/21 dotyczącego, istotnego z praktycznego punktu widzenia, problemu właściwej wykładni art. 99 ust. 3 ustawy Prawo farmaceutyczne1. W komentowanym wyroku powrócono do niedopuszczalnej nie tylko w świetle przyjętych w prawoznawstwie metod wykładni prawa, ale przede wszystkim wartości konstytucyjnych, rozszerzającej interpretacji przepisu art. 99 ust. 3 pkt 2 i 3 u.p.f., zakładającej, że „wymóg przestrzegania limitu aptek jest jednym z podstawowych warunków nie tylko dla uzyskania zezwolenia, ale także w dalszej działalności podmiotu prowadzącego aptekę”. Powyższy pogląd został już wielokrotnie i przekonująco odrzucony w najnowszym orzecznictwie Naczelnego Sądu Administracyjnego, dającemu początek stabilnej — jak można sądzić — linii orzeczniczej w kwestii tak zwanych ograniczeń antykoncentracyjnych w Prawie farmaceutycznym.
Umyślne przestępstwo przeciwko życiu, zdrowiu lub wolności jako podstawa wydziedziczenia (art. 1008 pkt 2 k.c.)
Authors: Wróbel Adam
Published: March 2023

Podjętym zagadnieniem badawczym jest kwestia umyślnego przestępstwa przeciwko życiu, zdrowiu lub wolności — popełnionego przez uprawnionego do zachowku względem spadkodawcy albo jednej z najbliższych jemu osób — jako podstawa wydziedziczenia. Instytucję tą ujawnia ustawodawca w przepisie art. 1008 pkt 2 k.c. Jest to regulacja „pogranicza” prawa cywilnego oraz prawa karnego. Do pojęć tam zawartych (jak na przykład przestępstwo umyślne przeciwko życiu, zdrowiu lub wolności spadkodawcy lub najbliższej mu osoby; osoby najbliższej; spadkodawcy) powinno przykładać się właściwą miarę: karnistyczną lub cywilistyczną. Wątpliwości może nastręczać możliwość stosowania wydziedziczenia, o którym mowa w art. 1008 pkt 2 k.c., jeżeli na przykład spadkodawca zaangażowany jest dobrowolnie w pewnych sytuacjach w konkretne działanie przestępne po stronie sprawczej; popełnione przestępstwo charakteryzuje się niską szkodliwością społeczną; źródłem wydziedziczenia są czyny sprzed wielu lat. Niemniej aby chociażby częściowo usunąć te wątpliwości, wysunięty zostaje konkretny postulat, propozycja de lege ferenda.
Avaliação do Sistema de Triagem de Manchester em Doentes com Crise de Encerramento Agudo Primário do Ângulo Iridocorneano: Um Estudo Retrospetivo
Authors: Ribeiro Margarida , Barbosa-Breda João , Gonçalves Francisco , Faria Pereira Ana , Falcão-Reis Fernando , Alves Flávio , E. Silva Sérgio , B. Melo António
Published: March 2023

Introdução: A crise de encerramento agudo primário do ângulo iridocorneano é uma emergência oftalmológica. O objetivo deste estudo foi descrever os casos admitidos no Serviço de Urgência do Centro Hospitalar Universitário São João, correlacionando a queixa inicial com o nível de triagem de Manchester atribuído e o tempo até observação por Oftalmologia e realização de iridotomia.Material e Métodos: Análise retrospetiva dos registos clínicos dos doentes com encerramento agudo primário do ângulo, admitidos no Serviço de Urgência entre janeiro de 2010 e dezembro de 2020. Foram revistos 2228 episódios com diagnóstico de glaucoma ou hipertensão ocular para identificação correta dos casos de crise de encerramento do ângulo. Foram extraídas variáveis, nomeadamente o nível de triagem de Manchester atribuído, queixa principal, pressão intraocular à admissão, especialidade responsável pelo primeiro contacto médico e tempos até observação por Oftalmologia e até iridotomia.Resultados: Foram identificados 120 doentes, 84 (70%) do sexo feminino, com idade média de 68 ± 12 (desvio padrão) anos. A pressão intraocular média à admissão foi de 53,4 ± 12,4 mmHg. Em 9,2% dos doentes a queixa principal foi não-ocular, enquanto 9,2% apresentavam queixas não-oculares e oculares associadas. A maioria (68,1%) dos doentes com queixas não-oculares ou mistas foi triada para um não-oftalmologista. Segundo o sistema de triagem, a maioria (66,7%) dos doentes foi triada com nível amarelo (urgente), 9,2% foram triados com laranja (muito urgente) e nenhum vermelho (emergente). O primeiro especialista a observar os doentes após a triagem foi um oftalmologista em 83,3% dos casos (corretamente triados), enquanto os restantes foram inicialmente observados por outra especialidade. O tempo mediano até observação por Oftalmologia foi de 288 minutos (min. 45, máx. 871) num doente incorretamente triado e 49 minutos (min. 15, máx. 404) (p < 0,001) em doentes corretamente triados. O tempo mediano até realização de iridotomia laser foi de 353 minutos (min. 112, máx. 947) nos doentes incorretamente triados e 203 minutos (min. 22, máx. 1440) nos corretamente triados (p < 0,001).Conclusão: A maioria dos doentes com crise de encerramento agudo primário do ângulo iridocorneano não foi triada de acordo com o grau de prioridade apropriado segundo o sistema de triagem de Manchester. Nos doentes que não foram imediatamente seguidos por Oftalmologia verificou-se um atraso significativo no diagnóstico e início do tratamento. Torna-se premente a consciencialização dos profissionais de saúde sobre esta condição clínica e a otimização do processo de triagem para minimizar a perda de visão.
Literature Review: Kualitas Hidup Pasien Carpal Tunnel Syndrome
Authors: Pratiwi Ica , Pambudi Pagan , Nurikhwan Pandji Winata , Dafif Muhammad Welly , Bakhriansyah Mohammad
Published: March 2023

Abstract: Carpal tunnel syndrome (CTS) is the most common type of peripheral mononeuropathy. CTS can interfere with a person's quality of life both physically and mentally and result in patients experiencing disturbances in their quality of life. The purpose of writing this literature review is to determine the quality of life of patients with Carpal Tunnel Syndrome. The reference data in this article review was obtained by searching using PubMed, Science Direct, and Google Scholar published from 2011 to 2021. After the search and article selection process, 10 articles were found that were included in this literature review. Of all the articles, there is one article which shows that Carpal Tunnel Syndrome does not affect the quality of life. While nine other articles show that Carpal Tunnel Syndrome can affect quality of life. Hand pain and dysfunction result in limited activity so this is related to bodily, psychological and social functions. The symptoms experienced by CTS patients cause increased anxiety, depression, limited daily activities, decreased effectiveness at work, and decreased sleep quality, causing patients to experience disturbances in their quality of life. Keywords : Carpal Tunnel Syndrome, quality of life, physical and mental health Abstrak: Carpal Tunnel Syndrome (CTS) merupakan jenis mononeuropati pererifer yang paling umum ditemui. CTS dapat mengganggu kualitas hidup seseorang baik secara fisik maupun mental dan mengakibatkan pasien mengalami gangguan dalam kualitas hidup mereka. Tujuan penulisan literature review ini adalah untuk mengetahui kualitas hidup pasien Carpal Tunnel Syndrome. Data acuan dalam kajian artikel ini didapatkan dengan penelusuran menggunakan PubMed, Science Direct, dan Google Scholar yang dipublikasikan pada tahun 2011 hingga tahun 2021. Setelah proses pencarian dan seleksi artikel, didapatkan 10 artikel yang disertakan pada literature review ini. Dari seluruh artikel, terdapat satu artikel yang menunjukkan bahwa Carpal Tunnel Syndrome tidak mempengaruhi kualitas hidup. Sedangkan sembilan artikel lainnya menunjukkan bahwa Carpal Tunnel Syndrome dapat mempengaruhi kualitas hidup. Nyeri dan disfungsi tangan mengakibatkan aktivitas terbatas segingga hal ini berkaitan dengan fungsi tubuh, psikologis dan sosial. Gejala-gejala yang dirasakan pada pasien CTS menyebabkan meningkatnya kecemasan, depresi, terbatasnya mengerjakan kegiatan sehari-hari, penurunan efektivitas dalam bekerja, dan penurunan kualitas tidur sehingga menyebabkan pasien mengalami gangguan dalam kualitas hidup mereka. Kata-kata kunci: Carpal Tunnel Syndrome, kualitas hidup, kesehatan fisik dan mental
PENGARUH PENYULUHAN TERHADAP PENGETAHUAN DAN SIKAP MENGONSUMSI TABLET TAMBAH DARAH
Authors: Abdillah Muhammad Azra Inan , Triawanti Triawanti , Rosida Azma , Noor Meitria Syahadatina , Muthmainah Noor
Published: March 2023

Iron supplementation tablets (TTD) are dietary supplements containing iron that can be given to adolescent girls to prevent iron deficiency anemia (ADB). Although the administration of TTD in adolescent girls has been implemented, the lack of knowledge and unsupportive attitude toward consuming TTD in adolescent girls can reduce the effectiveness on preventing ADB. This study aims to determine the effect of health education on knowledge and attitude of consuming TTD, a review of adolescent girls at SMP Negeri 25 Banjarmasin. Quasi-experimental research method with one-group pretest-posttest design. The research subjects were 30 people with random sampling technique. Data collection techniques using knowledge and attitude questionnaires. The analysis using the Wilcoxon Signed Ranks test showed that there was a significant difference between knowledge (p=0.00) and attitude (p=0.019) before and after health education for adolescent girls. In conclusion, health education can increase the knowledge and attitude of consuming TTD in adolescent girls
INVESTIGATING SPIRITUAL TOURISM EXPERIENCE QUALITY, DESTINATION IMAGE, AND LOYALTY: THE MEDIATING ROLE OF PERCEIVED SACREDNESS AND SUBJECTIVE WELLBEING
Authors: ROHMAN Fatchur , HUSSEIN Ananda Sabil , HAPSARI Raditha , TAMITIADINI Dian
Published: March 2023

Purpose – This study aims to ascertain the links between experience quality, destination image, subjective well-being, and perceived holiness, and their effects on Indonesian spiritual tourists’ loyalty.Design – This study was designed as descriptive and explanatory research to explain the relationship between the observed variables within the proposed model. Methodology – PLS analysis was used to analyze the data collected from 277 respondents. Findings – This study revealed that the most important indicators of tourist loyalty are the destination image and perceived sacredness. While experience quality does not have a direct influence on tourist loyalty, this study demonstrates that it does have a direct effect on subjective well-being. Destination image was also found to have a direct influence on subjective wellbeing and perceived sacredness. Furthermore, this study discovered that perceived sacredness has a considerable mediating influence on the effect of destination image on tourist loyalty. Originality of the research – This study develops a conceptual model to predict tourists’ loyalty in the context of spiritual tourism in Indonesia by combining the constructs of experience quality, destination image, subjective well-being, and perceived sacredness. Additionally, this study demonstrates the theoretical importance of perceived sacredness in mediating the influence of experience quality on tourists’ loyalty.
BOOKER PREDICTION FROM REQUESTS FOR QUOTATION VIA MACHINE LEARNING TECHNIQUES
Authors: RUNGGALDIER Samuel , SOTTOCORNOLA Gabriele , JANES Andrea , STELLA Fabio , ZANKER Markus
Published: March 2023

Purpose – Many incoming requests for quotation usually compete for the attention of accommodation service provider staff on a daily basis, while some of them might deserve more priority than others. Design – This research is therefore based on the correspondence history of a large booking management system that examines the features of quotation requests from aspiring guests in order to learn and predict their actual booking behavior. Approach – In particular, we investigate the effectiveness of various machine learning techniques for predicting whether a request will turn into a booking by using features such as the length of stay, the number and type of guests, and their country of origin. Furthermore, a deeper analysis of the features involved is performed to quantify their impact on the prediction task. Findings – We based our experimental evaluation on a large dataset of correspondence data collected from 2014 to 2019 from a 4-star hotel in the South Tyrol region of Italy. Numerical experiments were conducted to compare the performance of different classification models against the dataset. The results show a potential business advantage in prioritizing requests for proposals based on our approach. Moreover, it becomes clear that it is necessary to solve the class imbalance problem and develop a proper understanding of the domain-specific features to achieve higher precision/recall for the booking class. The investigation on feature importance also exhibits a ranking of informative features, such as the duration of the stay, the number of days prior to the request, and the source/country of the request, for making accurate booking predictions. Originality of the research – To the best of our knowledge, this is one of the first attempts to apply and systematically harness machine learning techniques to request for quotation data in order to predict whether the request will end up in a booking.
UNDERSTANDING SERVICE OUTCOMES IN THE SPA INDUSTRY
Authors: THIPBHAROS Piyavit , SANGPIKUL Aswin
Published: March 2023

Purpose - There is a scarcity of research to provide an in-depth understanding of spa service outcomes. This research note aims to examine the characteristics of spa service outcomes from three sources of information. Design/methodology - The information from past studies, online reviews, and customer interviews is analysed through a content analysis method. Findings - First, service outcomes in the spa industry involve two attributes: physical and mental outcomes. Second, the assessment of customer satisfaction on spa services includes two elements: service satisfaction and outcome satisfaction. Third, spa service outcomes may be regarded as a distinct variable as the experiences of spa service outcomes may be depended on certain factors (e.g. skills of therapists and the understanding of customer needs), meanwhile, they also have subsequent influences on post-consumption behaviours. Originality - This is an initial study to fully examine the characteristics of spa service outcomes. The study has conceptualised spa service outcomes for future investigation to strengthen knowledge development in the field.
Ultrasound-Based AI for COVID-19 Detection: A Comprehensive Review of Public and Private Lung Ultrasound Datasets and Studies
Authors: Morshed Abrar , Al Shihab Abdulla , Jahin Md Abrar , Al Nahian Md Jaber , Sarker Md Murad Hossain , Ibne Wadud Md Sharjis , Uddin Mohammad Istiaq , Siraji Muntequa Imtiaz , Anjum Nafisa , Shristy Sumiya Rajjab , Rahman Tanvin , Khatun Mahmuda , Javed Fakrul Islam , Dewan Md Rubel , Hossain Mosaddeq , Sultana Razia , Chakma Ripel , Emon Sonet Barua , Islam Towhidul , Hussain Mohammad
Published: March 2023

The COVID-19 pandemic has affected millions of people globally, with respiratory organs being strongly affected in individuals with comorbidities. Medical imaging-based diagnosis and prognosis have become increasingly popular in clinical settings to detect COVID-19 lung infections. Among various medical imaging modalities, ultrasound stands out as low-cost, mobile, and radiation-safe imaging technology. In this comprehensive review, we focus on ultrasound-based AI studies for COVID-19 detection that use public or private lung ultrasound datasets. We surveyed articles that used publicly available lung ultrasound datasets for COVID-19 and reviewed publicly available datasets and organize ultrasound-based AI studies per dataset. We analyzed and tabulated studies in several dimensions, such as data preprocessing, AI models, cross-validation, and evaluation criteria. In total, we reviewed 42 articles, where 28 articles used public datasets, and the rest used private data. Our findings suggest that ultrasound-based AI studies for the detection of COVID-19 have great potential for clinical use, especially for children and pregnant women. Our review also provides a useful summary for future researchers and clinicians who may be interested in the field.
A 3-Layer PSN for Image Encryption Utilizing Fractional-Order Chen Hyperchaotic Map and Cryptographically-Secure PRNGs
Authors: Alexan Wassim , Alexan Nader , Gabr Mohamed
Published: March 2023

Image encryption is increasingly becoming an important area of research in information security and network communications, as digital images are widely used in various applications and are vulnerable to various types of attacks. In this research work, a color image cryptosystem that is based on a 3-layer permutation-substitution network (PSN) is proposed. For every layer, an encryption key and an S-box are generated and utilized. Those are based on a four-dimensional (4D) dynamical Chen system of a fractional-order, the Mersenne Twister, OpenSLL, Rule 30 Cellular Automata and Intel’s MKL. The sequential application of Shannon’s ideas of diffusion and confusion for 3 times guarantees a total distortion of any input plain image, resulting in a totally encrypted one. Apart from the excellent and comparable performance to counterpart algorithms from the literature, showcasing resistance to visual, statistical, entropy, differential, known plaintext and brute-force attacks, the proposed image cryptosystem provides an exceptionally superior performance in 2 aspects: a vast key space of 2^1658 and an average encryption rate of 3.34 Mbps. Furthermore, the proposed image cryptosystem is shown to successfully pass all the tests of the NIST SP 800 suite.
The Philadelphia Chromosome, from Negative to Positive: a Case Report of Relapsed Acute Lymphoblastic Leukemia Following Allogeneic Stem Cell Transplantation
Authors: Marinescu Elena-Cristina
Published: March 2023

Relapsed acute lymphoblastic leukemia (ALL) represents a continuous challenge for the clinician. Despite recent advances in treatment, the risk of relapse remains significant. The clinical, biological, cytogenetic, and molecular characteristics may be different at the time of relapse. Current comprehensive genome sequencing studies suggest that most relapsed patients, especially those with late relapses, acquire new genetic abnormalities, usually within a minor clone that emerges after ALL diagnosis. We report the case of a 23-year-old young woman diagnosed with Philadelphia chromosome negative B-cell acute lymphoblastic leukemia. The patient underwent allogeneic stem cell transplantation (allo-HSCT) after complete remission. Although having favorable prognostic factors at diagnosis, the disease relapsed early after allo-HSCT. The cytogenetic and molecular exam at relapse was positive for the Philadelphia chromosome, respectively for the bcr-abl transcript. What exactly led to the relapse of this disease in a more aggressive cytogenetic and molecular form, although there were no predictive elements in the diagnosis of this relapse?
MRI-AGCM Global Warming Experiments towards the Rainfall Characteristics over India
Authors: Nayak Sridhara
Published: March 2023

We investigated rainfall patterns in India over during the 60-year period from 1951 to 2010 and predicted changes for the next century (2051-2100) with an assumed 4K warming from large ensemble experiments (190 members). We focused on rainfall patterns during two periods of present-day climate (1951-1980 and 1981-2010) and their projected changes for the near and far future (2051-2080 and 2081-2110). Our analysis revealed that the northeastern region of India and some southern regions received higher rainfall during the period of 1951-2010. This finding is consistent with daily observations from the Asian Precipitation Highly Resolved Observational Data Integration Towards Evaluation (APHRODITE). In a warming climate, rainfall events in India are predicted to carry more precipitation, with the northeast and southern regions experiencing stronger rainfall events. The frequency and intensity of these events (with more than 20mm of rainfall per day, on average) are also expected to increase. Overall, our study suggests that water-related disasters such as flooding and landslides could be much worse in India in the future due to climate warming.
ESTIMATION OF LAND SURFACE TEMPERATURE-ASSESSMENT WITH REMOTE SENSING DATA FOR URBAN HEAT ISLAND IN BATAM MUNICIPALITY
Authors: Anurogo Wenang , Sidabutar Rapena Tandon Cahayanti , Lubis Muhammad Zainuddin , Panuntun Hidayat , Nugroho Cahyo Budi , Sufwandika Muhammad
Published: March 2023

Urban Heat Island (UHI) is a phenomenon where the surface temperature in urban areas is higher than in the surrounding area or in open-air areas. Hilly city continues to increase every year. Because of that, it needed an effort at the city-level urban heat island on Batam Island. Through the Thermal Landsat 8 channel image recording May 24, 2018 sensing data can be used to complete the heat calculation of the urban heat Island on Batam Island. This research aims to determine the variation of Urban Heat Island (UHI) effect on land cover in the research area. This research uses LST and maximum likelihood multispectral classification for the land cover area and NDVI transformation. The results of the processing are obtained with an R2 value of 0.872324 with a UHI intensity of 0-8.06 ̊ C. This shows the amount needed by Urban Heat Cities in Batam Island specifically in urban areas such as Batu Ampar District, Batam Kota, Bengkong, Batu Aji, Lubuk Baja, Sagulung, and Sekupang
APPLICATION OF THE LIGEKA_21 MODEL TO DEVELOP 21ST-CENTURY SKILLS FOR STUDENTS IN LEARNING GEOGRAPHY IN HIGH SCHOOL
Authors: Sugiyanto Sugiyanto , Prihadi Singgih , Ronggowulan Lintang
Published: March 2023

21st Century learning skills are essential. In the revision of the 2013 curriculum in 2017, it has been explicitly stated that 21st-century skills introduced with the term 4 C (Critical thinking and problem solving, creativity and innovation, communication skills and collaboration skills) are used as an orientation in learning at school. To improve students' 21st Century Skills in Social Studies learning, a learning model called the LIGEKA_21 was developed. The results of his research show that the use of the LIGEKA_21 model can significantly improve 21st-century skills (4C) for both students in the high school group and the middle and lower group schools. Prominent results include high enthusiasm for learning, active and creativity in producing learning outputs, posters of critical and creative teaching materials, poetry based on social studies teaching materials, high mastery of social studies knowledge, development of communication skills and skills and collaboration. The results of this good research need to be developed more broadly, not only in junior high schools but also need to be developed in senior high schools. Good learning outcomes implemented using face-to-face (offline) patterns are not necessarily suitable in the Covid-19 era, which are carried out with online learning patterns, so they must be developed or adapted based on e-learning. Based on these conditions, this research will develop an online learning pattern based on the LIGEKA 21 model, which will then be compared with the LIGEKA_21 model with face-to-face (offline) learning patterns in high school.
PENINGKATAN MINAT BELAJAR SISWA MELALUI PENGEMBANGAN E-MODUL PADA PELAJARAN KBGT (Kerja Bengkel dan Gambar Teknik) PADA ERA NEW NORMAL DI SMKN 8 MALANG
Authors: Alfarozi Afan , Saputra Ulfa Rahayu , Syaifudin Ahmad , Tuwoso Tuwoso
Published: March 2023

The pandemic makes learning in the school environment limited, as a result the ability of students to understand and master the material of a subject decreases. Distance learning / online is the main choice so that the learning process continues. Online learning results in limited students getting learning resources from textbooks, so that their interest in reading and learning decreases. Researchers make innovations to overcome these problems by making an e-module product as student learning material with concepts and material content that are more interesting and easily understood by students. It is hoped that this e-module can increase students' interest in learning in KBGT lessons (workshop work and technical drawing) at SMKN 8 Malang. This study uses the Borg and Gall version of the R&D (Research & Development) method which is simplified by Anik Ghufron. The development model used has four stages, namely preliminary studies, development, field testing, and product development dissemination. This research is based on interviews and validation questionnaires. The results showed that the KBGT e-module developed was declared very feasible with a material validity value of 3.35 and media value of 3.43.
Quality E-Wallet Transaction Services for Indonesia's Millennial Student Generation
Authors: Selsapagita Indah , Sukardi Budi
Published: March 2023

The study aims to determine the influence of the quality of e-wallet transaction services simultaneously on the lifestyle of Solo Raya millennial students and determine the most dominant variables affecting the lifestyle of Solo Raya millennial students. A quantitative approach was used in this study. The study population consisted of millennial students in Solo Raya. The research sampling method was purposive and used predetermined criteria. Data collection techniques included documentation, literature review, and questionnaires. Data analysis using multiple regression techniques. The result of the study is that the quality of e-wallet transaction services simultaneously significantly affects the lifestyle of millennial students in Solo Raya. The most dominant variable affecting the lifestyle of the Solo Raya millennial students was reliability.
An Ensemble model for automated attack classification in large scale wireless sensor network using Mobile Agent based Intrusion Detection System
Authors: kaur prabhjot , Rana Prashant Singh , Batra Shalini
Published: March 2023

The latest technology trend is the conflation of mobile agent technology for high-level inference and surveillance in wireless sensor networks. Bridging the two technology contributes to the emerging areas and acquiring foremost importance in communication. The sensor nodes shift from fixed to a dynamic environment that changes rapidly becomes prone to malicious attacks. This work considers the attacks which cause the communication failure and raises the alarm for appropriate action. A scheme has been defined to collect sufficient data to identify the abnormal behaviour on sensor nodes from Network Simulator (NS-2.35) on the defined features with mobile agent based intrusion detection system (IDS) using SPIN protocol is one of the most useful data-centric routing protocols in WSNs. This work describes a novel approach for classifying attacks based on consumed energy onto different parameters. Furthermore, on the basis of attacks type, a performance matrix is computed by standard classifiers with machine learning models. An ensemble model is proposed to improve the performance of the ensemble classifiers, which yields an average accuracy of 95%. Further, K Fold cross validation has been performed to check the consistency of the proposed ensemble model.
Temporal Architecture of Suicide: Interacting Immediate and Long-Term Action Regulation with History of Medically Severe Suicide Attempt
Authors: Swann Alan , Murphy Nicholas , Lijffijt Marijn , Kypriotakis George , O’Brien Brittany , Amarneh Dania , Moukaddam Nidal , Averill Lynette , Vo-Le Bylinda , Mathew Sanjay , Tamman Amanda , Kosten Thomas
Published: March 2023

Imminent suicide is difficult to predict. Suicide usually occurs on the first attempt. Suicide may consist of suicidal crises, with fluctuating and unpredictable risk, superimposed on long-term latent susceptibility. Risk characteristics are consistent with interacting long-term (sensitization) and short-term (impulsivity) mechanisms: sensitization to stress/trauma perceived as inescapable, or to addiction, can increase latent action-impulsivity, disinhibiting high-risk behavior including suicidal ideation and aggression. Survived medically severe suicide attempts are associated with severe morbidity and premature death. Therefore, it is necessary to identify characteristics that may predict a first attempt. We used Bayesian logistic regression and path analysis to identify direct and indirect (via suicidal ideation-worst (SSI-W)) predictors of MSSA in 28 adult survivors of MSSA and 23 symptomatically and demographically similar non-attempters (NA). SSI-W increased odds ratio (OR) for MSSA; Cumulative Adversity and action-impulsivity increased OR for MSSA independent of SSI-W. SSI-W mediated increased MSSA by aggression, alcohol use, and depression. Childhood Trauma Minimization/Denial increased MSSA directly but correlated negatively with SSI-W. MSSA required latent aggression or impulsivity combined with stress-sensitization and increased action-impulsivity. These interacting characteristics are potential targets for identification and preventive treatment of risk for suicide regardless of attempt history.
The ABIC score for Assessing Long-term Outcomes in Elderly Hospitalized Patients with Acute Exacerbations of Chronic Heart Failure
Authors: Lin Zebin , Deng Manxiang , Xiao Li , Qi Chenlu , Song Siqi , Zhao Yiping
Published: March 2023

Objectives: Age-bilirubin-international normalized ratio -creatinine (ABIC) score was originally proposed as a tool to assess alcoholic hepatitis survival and to identify patients who respond to corticosteroid treatment. Since the components of this score are associated with prognosis in patients with heart failure, the purpose of this study was to determine the relationship between ABIC score and long-term prognosis of elderly patients with acute exacerbation of chronic heart failure.
Methods: This is a retrospective cohort study of elderly patients with acute exacerbation of chronic heart failure who were hospitalized for the first time in the Second Affiliated Hospital of Chongqing Medical University from February 2017 to December 2017. The main clinical outcome was all-cause mortality within three years. Cox regression and Lasso regression were used to screen variables and build a prognostic model. Combined with the ABIC score, the final model was adjusted, and the predictive ability of the model was evaluated. The screened variables with ABIC score were incorporated into the multivariate Cox regression analysis and a nomogram prediction model was built. The receiver operating characteristic curve and calibration curve were used to evaluate the predictive ability and accuracy of the model, respectively.
Results: A total of 365 patients with acute exacerbation of chronic heart failure were included (median age 78 years, 50.7% female). During the 3-year follow-up period, 87 patients experienced all-cause death, including 53 cardiac deaths. A total of 4 variables (NT-proBNP, BUN, RDW-CV and prealbumin) were screened by univariate Cox regression analysis and Lasso regression analysis. The multivariate COX regression results showed that the risk of death increased by 33% with the increase of ABIC score by 1 point (after correcting NT-proBNP, BUN, RDW-CV and prealbumin). The results of ROC curve analysis show that the area under the curve (AUC) of the ABIC score is 0.685, while the AUC of the Nomograph including the ABIC score is 0.840.
Conclusions: The ABIC score is associated with long-term adverse outcomes in elderly hospitalized patients with chronic heart failure exacerbations. But its predictive ability for adverse events needs further exploration.
A VV-ECMO supported severe pneumonia caused by Chlamydia abortus: a case report
Authors: Yip wahkwong , wu bin , ye baohua , ji chengyi , wu ziyao , chen minli , lin chunmiao , Ye Jialiang , ke wenzhi , chen qiuyan , xu shumin , chen huimin
Published: March 2023

Background:
Human infection with Chlamydia abortus is very rare, mainly described as septicemia and abortion in pregnant women with previous Chlamydia abortus exposure. Though there is a case of atypical pneumonia caused by Chlamydia abortus in 2016, none of the reported infections manifested primarily as severe hypoxemia.
Case Presentation:
A 69-year-old male farmer admitted to our ICU for pneumonia caused severe hypoxemia, with PaO2 /FiO2 ratio dropped to 53.1 mmHg when under mechanical ventilation. Bronchoalveolar lavage fluid(BALF) for untargeted metagenomic NGS was taken soon after VV- ECMO support. Sequencing results indicate Chlamydia abortus is the pathogen. The patient operated a farm raising more than a hundred pigs and some poultry before the disease, with no ruminant in the farm, and the possibility of contact was denied. Two weeks later, the patient was weaned from ECMO, recovered, and was discharged a month later.
Conclusion:
Chlamydia abortus infection in humans may as well cause severe pneumonia with hypoxemia and need ECMO support. clinician veterinarians and public health officials should be aware of possible severe pulmonary infection due to Chlamydia abortus.
Astrocytes mediate cerebral blood flow and neuronal response to cocaine in prefrontal cortex
Authors: Pan Yingtian , Du Congwu , Park Kicheon , Hua Yueming , Volkow Nora
Published: March 2023

Cocaine affects both cerebral blood vessels and neuronal activity in brain. Cocaine can also disrupt astrocytes, which are involved in neurovascular coupling process that modulates cerebral hemodynamics in response to neuronal activity. However, separating neuronal and astrocytic effects from cocaine’s direct vasoactive effects is challenging, partially due to limitations of neuroimaging techniques to differentiate vascular from neuronal and glial effects at high temporal and spatial resolutions. Here, we used a newly-developed multi-channel fluorescence and optical coherence Doppler microscope (fl-ODM) that allows for simultaneous measurements of neuronal and astrocytic activities alongside their vascular interactions in vivo to address this challenge. Using green and red genetically-encoded Ca2+ indicators differentially expressed in astrocytes and neurons, fl-ODM enabled concomitant imaging of large-scale astrocytic and neuronal Ca2+ fluorescence and 3D cerebral blood flow velocity (CBFv) in vascular networks in the mouse cortex. We assessed cocaine’s effects in the prefrontal cortex (PFC) and found that the CBFv changes triggered by cocaine were temporally correlated with astrocytic Ca2 +A activity. Chemogenetic inhibition of astrocytes during the baseline state resulted in blood vessel dilation and CBFv increases but did not affect neuronal activity, suggesting modulation of spontaneous blood vessel’s vascular tone by astrocytes. Chemogenetic inhibition of astrocytes during cocaine challenge prevented its vasoconstricting effects alongside the CBFv decreases but also attenuated the neuronal Ca2 +N increases triggered by cocaine. These results document a role of astrocytes both in regulating vascular tone of blood flow at baseline and for mediating the vasoconstricting responses to cocaine as well as its neuronal activation in the PFC. Strategies to inhibit astrocytic activity could offer promise for ameliorating vascular and neuronal toxicity from cocaine misuse.
Self-Locking Kirigami Surfaces via Controlled Stretching
Authors: Zhang Qian , Pan Ning , Liu Shuangbo , Feng Jian , Cai Jianguo
Published: March 2023

Kirigami provides a powerful strategy to transform two-dimensional elements into complex three-dimensional functional structures with lengths ranging from nanoscale to microscale and macroscale. The stability of mechanically induced forming three-dimensional structures using external or self-balancing actuation is crucial. The applicability of the actuator method to the modularity and programmability of the kirigami element is also a key issue in the forming process. Here, we offer a three-dimensional self-locking element forming pattern achieved by in-plane tension and release, manifested as a combination behavior of out-plane popping and rotation. The range of geometric parameters for kirigami elements with different stability properties is determined theoretically. And the in-plane tension conditions are also calculated to break the transition point of the forming process. The horizontal and vertical modular array analysis demonstrates the scalability and programmability from the self-locking elements to the kirigami surfaces. We expect that the kirigami pattern and design approach will serve for innovative systems, including tunable antennas, flexible electronics, and medical devices.
Spatio-spectral 4D Coherent Ranging Using a Flutter-wavelength-swept Laser
Authors: Jeong Dawoon , Jung Min Uk , Jang Hansol , Jeong Taeho , Kim Hyunsoo , Yang Sanghyeok , Lee Janghyeon , Kim Chang-Seok
Published: March 2023

Coherent light detection and ranging (LiDAR), particularly the frequency-modulated continuous-wave LiDAR, is a powerful optical imaging technology for long-distance three-dimensional (3D) ranging and velocity measurement. Spatio-spectral LiDAR was proposed to perform coherent ranging and solid-state beam scanning simultaneously; however, a complete four-dimensional (4D) implementation, combined with 3D distance and velocity measurements over tens of meters, has not yet been reported owing to the limitations of commercial wavelength-swept lasers. Herein, we propose a novel flutter-wavelength-swept laser that offers a simultaneous yet independent wavelength modulation of 5–6 pm for axial distance and velocity measurement, and a wavelength sweep of 160 nm for horizontal beam scanning. An acousto-optical scanner was synchronized to support the remaining vertical beam scanning for a perfect solid-state coherent LiDAR. The proposed spatio-spectral LiDAR system achieves a high-resolution coherent ranging over 20 m and 4D real-time imaging with 200 × 45 pixels in a 10 Hz frame rate.
Impact of CNT addition on Surface Roughness and Dimensional Characteristics of Polymer Nano-Composite Fabricated by FDM method
Authors: Mohanavel V. , Kannan S. , Mohan R. , Arul K. , Seikh A.H , Iqbal A.
Published: March 2023

Nowadays, companies frequently employ additive manufacturing or 3D printing technologies to check the fitting, shape, and functioning of a planned product preceding design approval and implementation. As additive manufacturing does not require process design, jigs, fixtures, specialized tool path creation, etc., it minimizes the overall manufacturing duration as compared to traditional production. Fused deposition modeling is the kind of additive manufacturing technology that is most frequently employed in the industry. In order for fused deposition modeling to function, extrusion polymer from a nozzle that is preheated between the flow and melting temperature must be deposited layer after layer.The current experimental investigation examines the effect of carbon nanotube addition into the polylactic (PLA) polymer matrix using the fused deposition modeling technique. By combining polylactic acid with carbon nanotubes in the amounts of 0 percent, 0.5 percent, 1 percent, 1.5 percent, and 2 weight percent, an innovative thermoplastic nanocomposite was created. Twin-screw extrusion was employed to create the composite filament. After the successful fabrication of nanocomposites, the effect of varying concentration nanotube addition on the microstructure, surface roughness, and dimensional accuracy of FDM parts was studied. With the incorporation of carbon nanotube, the surface roughness appeared to decrease along the building direction. To comprehend the dispersion of graphene in the PLA matrix and its effects on the study's parameters, these properties were examined.
The importance of oral health in patients with T2DM: A cross-sectional study.
Authors: Zhang Dongxue , Cheng Qian , Liu Wenyan , Zhang Tianyi , Ding Yukun , Fan Jing , Gu Yanan , Li Yufeng , Lin Mei
Published: March 2023

Objective To evaluate the association between systemic factors and periodontal status in patients with type 2 diabetes mellitus (T2DM).
Methods A total of 169 patients with T2DM and periodontitis were included in this study. Patients were divided into three groups: mild periodontitis, moderate periodontitis and severe periodontitis. Periodontal parameters (PD, CAL and BI) were evaluated. FPG, HbA1c and Hs-CRP levels were measured in fasting venous blood. The association between insulin use and severity of periodontitis was investigated in ordered logistic and binomial logistic regression models.
Results Ordered logistic regression analysis showed insulin use had a statistically significant influence on severity of periodontitis: OR 2.36 [95%CI: 1.23-4.55, P=0.010] after adjusting for age and gender; OR 2.10 [95%CI: 1.05-4.18, P=0.035] after adjusting for age, gender, smoking status, daily toothbrushing frequency and HbA1c level; OR 2.04 [95%CI: 1.01-4.14, P=0.048] after adjusting for age, gender, smoking status, daily toothbrushing frequency BMI, HbA1c level, FPG, statin and biguanide use. Binomial logistic regression models showed an association between insulin use and moderate to severe periodontitis: OR 2.44 [95% CI: 1.24-4.94, P=0.011] after adjusting for age and gender; OR 2.17 [95% CI: 1.07-4.53, P=0.035] after adjusting for age, gender, smoking status, daily toothbrushing frequency and HbA1c level; OR 2.13 [95% CI: 1.03-4.56, P=0.046] after adjusting for age, gender, smoking status, daily toothbrushing frequency BMI, HbA1c level, FPG, statin and biguanide use.
Conclusion Patients with T2DM who require insulin injections have a high risk for moderate to severe periodontitis and should be provided oral health education.
Analysis of the characteristics of the organisms，risk factors and preventive strategies for infection after colorectal cancer surgery
Authors: Hou Xidong , Liu Mengxing , Gu Huawei , Li Dan , Lin Mingzhu
Published: March 2023

Background Internal hospital infection is one of the major public health concerns worldwide. To investigate the etiological characteristics and risk factors of infections after colorectal cancer(CRC) surgery and the formulation of targeted infection control strategies.
Methods This is a retrospective analysis of 1500 patients from colorectal cancer patients from General Surgery between March 2018 and March 2022，Anyang Tumor Hospital. Based on pathogen distribution and results of drug sensitivity testing, pattern of pathogens and drug resistance in infection in hospitalized patients with with colonic malignancy were analyzed. We conducted univariate and multivariate logistic regression analyses to determine the risk factors of infections that are associated with postoperative colorectal cancer.
Results Infection cases were noted in 5.20% of all 1500 cases (78 of 1500 CRC patients). Drug resistance pattern showed that 88.89% of the implicated coagulase-negative staphylococci species and 40% of the implicated Acinetobacter species were meropenem-resistant. Considering all infection sites, age >60 years (OR=2.190, P=0.002), diabetes mellitus (OR=2.044, P=0.005), operation time >3h (OR=2.178, P=0.002) ), hospitalization time >10d (OR=1.793, P=0.017), parenteral nutrition (OR=2.797, P=0.000), indwelling catheter (OR=1.699, P=0.038), mechanical ventilation (OR=2.294, P=0.001) and the usage of drainage tube (OR=3.455, P=0.000) were risk factors at multivariate analysis.
Conclusions: Post-operative infections may negatively affect surgical outcomes. Based on the greatest available evidence,important preoperative risk factors for postoperative colorectal cancer infections have been identified. Knowledge on risk factors may influence treatment and procedure-related decisions, and possibly reduce the postoperative infection rate.
Urinary cortisol level in exclusion autonomous cortisol secretion in the patient of primary aldosteronism
Authors: Chu Wen-Kai , Wang Chih-Yuan , Wu Wan-Chen , Wu Vin-Cent
Published: March 2023

Background
Serum cortisol level after 1-mg overnight dexamethasone suppression test (1-mg DST) below 1.8 ug/dL was a diagnostic criterion for having autonomous cortisol secretion (ACS), whether the cut-off point in 24-hour urine-free cortisol (24-h UFC) for the patient suspecting with primary aldosteronism (PA) concomitant ACS is unclear.
Methods
This prospective observational study enrolled 274 patients diagnosed with PA from January 2017 to January 2020 (male, 42.3%; mean age, 55.9 ± 11.7 years). Serum cortisol level after 1 mg DST over 1.8 ug/dL was a diagnostic criterion for ACS, confirmed with a second repeated test.
Results
Of the 274 PA patients, 74 patients (27%) with PA had concomitant ACS while the other 200 patients were not. Logistic regression analysis showed patients with PA concomitant ACS were associated with higher 24-h UFC (OR, 1.91 [95% CI, 1.06–3.41], P=0.03), older age (OR, 1.04 [95% CI, 1.01–1.07], P=0.008), and diabetes mellitus (OR, 2.4 [95% CI, 1.12–5.12], P=0.025). The generalized additive model (GAM) for urinary cortisol and ACS showed the 24-h UFC above 36 μg, concurrent with the positive predictive value of 32.6% and negative predictive value of 77.9% could be a factor predicting a higher possibility of ACS.
Conclusions
More than a quarter of PA patients concomitant ACS. Our study suggested the 24-h UFC less than 36 μg as a cut-off point in exclusion of the patient with PA concomitant ACS. Additionally, older age and diabetes mellitus were also risk factors for predicting patients with PA concomitant ACS.