bluuebunny/crossref_metadata_2025 huggingface dataset:
El macro-modelat de la costa carbonàtica de Victòria (Austràlia): paral·lelismes i diferències amb les cales baleàriques
Authors: Gómez-Pujol Lluís
Published: October 2019

Les cales són penetracions marines, preferentment a un litoral carbonatat de caràcter tabular, arran de la inundació eustàtica d’un antic curs fluvial en la morfogènesi de les quals, de més a més del paper de la fracturació distensiva i la carstificació, també hi participen els mecanismes de col·lapse i la dinàmica litoral així com les variacions glacio-eustàtiques del nivell marí, especialment durant el Quaternari. El present treball aborda la tipologia i característiques dels elements del macro-modelat de la costa rocosa de Victòria (sud d’Austràlia) i les compara amb els antecedents i el coneixement obtingut en l’estudi de les cales de la Mediterrància occidental, principalment les de les Illes Balears. Els resultats posen de manifest que, de més a més del control estructural, les components fluvials i càrstiques o del retoc associat a l’erosió marina –tot incorporant les fluctuacions del nivell marí– hi ha altres factors que ajuden a explicar la diferència i el grau de maduresa en l’evolució morfològica del macro-meso modelat de les costes rocoses carbonatades. Resulta important considerar el paper dels heretatges geològics en el sentit que, esdeveniments de gran transcendència, com per exemple la crisi de salinitat del Messinià a la Mediterrània, poden deixar una empremta que condicioni i governi el desenvolupament i característiques de les cales i així es puguin explicar les diferències entre planells carbonàtics relativament semblants. Així doncs, un altre factor ha de considerar-se entre els controls-components agents que governen la forma de les cales: els heretatges geològics.
RACIONALNO UPRAVLJANJE RESURSIMA KOMERCIJALNE BANKE
Authors: Kajtazović Ibrahim
Published: October 2019

Upravljanje bankarskim resursima je složeno i zavisi od više faktora. Stoga pojedinačni faktor, bez obzira koliko bio značajan, nije dovoljan da se racionalno upravlja ovim resursima. S obzirom da su resursi banke različiti i da ih sve nije moguće, niti potrebno držati pod kontrolom, banka se obično koncentriše na njihove najznačajnije kategorije. S tim u vezi banka mora prvo da definiše poslovnu politiku kao sredstvo za ostvarivanje postavljenih ciljeva, budući da njih nije moguće ostvariti ako se racionalno ne upravlja bankarskim resursima. Osim internih faktora, bankamora da respektira makroekonomske okolnosti i institucionalni okvir monetarne politike i faktore koji djeluju na fokusiranom tržišnom segmentu. Poslovna politika banke mora biti prilagodljiva i efikasna, ali i da odražava stabilnost, što podrazumijeva da se poštuju faze u njenom donošenju i da se pravilno kvantificiraju unutrašnji faktori, a vanjski anticipiraju. S obzirom da su veličina banke i geografski obuhvat primarnih plasmana, organizacija, planiranje i drugi elementi poslovanja u ingerenciji nosilaca upravljanja bankarskim resursima, oni su sa internog aspekta posmatrano ključni elementi za definiranje poslovne politike banke.
MEĐUNARODNA REGULACIJA OTMICA DJECE
Authors: Katić Miro
Published: October 2019

Pojava međunarodnih otmica djece nije novijeg vijeka, iako je termin „otmica“ relativno novijeg datuma. Proučavanjem antičkih pravnih izvora (rimsko pravo, prava u antičkoj Grčkoj, prava u Mesopotamiji, itd.) mogu se pronaći pravni fragmenti koji govore o roditeljima koji svoje dijete „odvedu“, roditeljima koji svoje dijete „zadrže“, roditeljima kojima dijete „pripadne“ i sl. Međunarodne otmice djece, odnosno protivpravno odvođenje djeteta iz jedne države u drugu, predstavlja problem kojiza sobom povlači niz otvorenih pitanja blisko povezanih sa ličnošću djetata, dok pravno gledano, takva pojava dovodi do sukoba zakona i nadležnosti između različith država, odnosno države djetetovog uobičajnog boravišta i države u koju je dijete nezakonito odvedeno. Države kroz prizmu instituta međunarodnog privatnog prava, uključujući i dostignuća Haške konvencije o građansko-pravnim aspektima međunarodnih otmica djece, nastoje doći do najboljih rješenja kojima se reguliše sukob zakona i nadležnosti između država.
Status of the World Heritage City — a «kiss of death» or resource in a conflict of interest? The case of Stralsund and Wismar
Authors: Eremenko Iuliia Andreevna
Published: October 2019

This article examines the transformation of urban space associated with the status of the World Heritage City, as well as the conflicts arising in this regard. The author faces a question whether the status of the World Heritage City does not allow any changes or they are possible, and the status is the resource in a conflict of interests. The two German cities Stralsund and Wismar with shared status of the World Heritage City were selected as the cases for this work. The research material contains the collected by the author expert interviews with the municipal administration, local activists, employees of the museums and tourist centers, and representatives of the local business. The article also analyzes the material from the two groups on Facebook belonging to the municipal government and the Green Party of Stralsund. The study demonstrates that the status of the World Heritage City imparts strict limitations upon the transformations of the urban space, but does not make their implementation completely impossible. There are times when different actors, such as municipal administration, use the status in diverse ways, depending on their interests.
Endothelial PKA activity regulates angiogenesis by limiting autophagy through phosphorylation of ATG16L1
Authors: Zhao Xiaocheng , Nedvetsky Pavel , Stanchi Fabio , Vion Anne-Clemence , Popp Oliver , Zühlke Kerstin , Dittmar Gunnar , Klussmann Enno , Gerhardt Holger
Published: October 2019

The cAMP-dependent protein kinase A (PKA) regulates various cellular functions in health and disease. In endothelial cells PKA activity promotes vessel maturation and limits tip cell formation. Here, we used a chemical genetic screen to identify endothelial-specific direct substrates of PKA in human umbilical vein endothelial cells (HUVEC) that may mediate these effects. Amongst several candidates, we identified ATG16L1, a regulator of autophagy, as novel target of PKA. Biochemical validation, mass spectrometry and peptide spot arrays revealed that PKA phosphorylates ATG16L1α at Ser268 and ATG16L1β at Ser269, driving phosphorylation-dependent degradation of ATG16L1 protein. Reducing PKA activity increased ATG16L1 protein levels and endothelial autophagy. Mouse in vivo genetics and pharmacological experiments demonstrated that autophagy inhibition partially rescues vascular hypersprouting caused by PKA deficiency. Together these results indicate that endothelial PKA activity mediates a critical switch from active sprouting to quiescence in part through phosphorylation of ATG16L1, which in turn reduces endothelial autophagy.
In vivo functional diversity of midbrain dopamine neurons within identified axonal projections
Authors: Farassat Navid , Costa Kauê Machado , Stojanovic Strahinja , Albert Stefan , Kovacheva Lora , Shin Josef , Egger Richard , Somayaji Mahalakshmi , Duvarci Sevil , Schneider Gaby , Roeper Jochen
Published: October 2019

Functional diversity of midbrain dopamine (DA) neurons ranges across multiple scales, from differences in intrinsic properties and connectivity to selective task engagement in behaving animals. Distinct in vitro biophysical features of DA neurons have been associated with different axonal projection targets. However, it is unknown how this translates to different firing patterns of projection-defined DA subpopulations in the intact brain. We combined retrograde tracing with single-unit recording and labelling in mouse brain to create an in vivo functional topography of the midbrain DA system. We identified differences in burst firing among DA neurons projecting to dorsolateral striatum. Bursting also differentiated DA neurons in the medial substantia nigra (SN) projecting either to dorsal or ventral striatum. We found differences in mean firing rates and pause durations among ventral tegmental area (VTA) DA neurons projecting to lateral or medial shell of nucleus accumbens. Our data establishes a high-resolution functional in vivo landscape of midbrain DA neurons.
Los entretejidos del conocimiento complejo. El lugar de la Teología en la interrelación de humanidades, ciencias y saberes en tiempos posmodernos y decoloniales
Authors: Mendoza-Álvarez Carlos
Published: October 2019

A relação da universidade ocidental com o ambiente social e ecológico em tempos de modernidade tardia é complexa, porque se move entre os polos de um modelo de civilização em crise e a alvorada de uma nova configuração de conhecimento que torne sustentável a vida do planeta e da humanidade. Nesse contexto, colocam-se as coordenadas do complexo conhecimento em que a universidade e os movimentos sociais de vítimas sistémicas – como testemunhas do outro lado da modernidade – se abrem para uma nova relação epistémica. Nesta hora crucial, é urgente resgatar o estatuto cognitivo do conhecimento tradicional negado pela racionalidade instrumental, para preservar a vida, dialogando com o pensamento crítico próprio do Ocidente, por fim consciente dos seus próprios limites. Desenha-se assim um modelo de teologia decolonial, nas suas características iniciais – como parte de um diálogo crítico – para construir um novo ethos cultural, político e espiritual, nesta hora marcada por uma racionalidade apocalíptica. Repensar a interdisciplinaridade exige, portanto, não apenas um diálogo científico, mas também a capacidade de construir o conhecimento como uma “ecologia de saberes”, para além de um modelo hegemónico de conhecimento, baseado numa racionalidade instrumental, que está a chegar ao fim. Dentro desse diálogo, a teologia tem um papel irrevogável, que reside em regressar à sua intencionalidade messiánica e kairológica, para pensar sobre a redenção que ocorre neste “tempo do fim”.
Teologia e Ciência da Religião: identidades e relações
Authors: Passos João Décio
Published: October 2019

Teologia e ciência da religião constituem duas abordagens distintas, o que se evidencia do ponto de vista histórico e epistemológico. As relações entre as duas áreas são constatadas ao longo da história; ocorrem de modo espontâneo ou de modo deliberado e programático, embora seja um processo inacabado na conjuntura acadêmica e científica atual. As universidades constituem, por sua vez, o lugar natural de ambas e se mostram como protagonistas habilitadas a conduzir o processo de afirmação das identidades e de diálogo entre o conhecimento clássico, a teologia, e a ciência moderna da religião.
A antiga modernidade do diálogo entre teologia e literatura
Authors: Boas Alex Villas
Published: October 2019

O presente artigo pretende destacar como uma perspectiva de poiésis cristã, como forma de pensamento poético está presente desde a literatura bíblica e perpassa a literatura de inspiração cristã, especialmente em dois elementos intimamente relacionados, a contemplação de imagens poéticas e a ideia de um itinerário de busca. Tais traços podem ser encontrados ao longo da literatura de inspiração cristã, mas especialmente são evidenciados em Dante Alighieri como pensamento poético teológico, que inspirará a literatura moderna e contemporânea.
Knowledge, attitudes, and practices about dengue among pupils from rural schools in an endemic area in Colombia
Authors: Sarmiento-Senior Diana , Matiz María Inés , Jaramillo-Gómez Juan Felipe , Olano Víctor Alberto , Vargas Sandra Lucía , Alexander Neal , Lenhart Audrey , Stenström Thor Axel , Overgaard Hans Jörgen
Published: October 2019

Introduction: Dengue is a public health problem in tropical and subtropical regions of the world. Studies on dengue in rural areas are scarce since the disease is considered mainly urban.Objective: To determine the knowledge (K), attitudes (A) and practices (P) of dengue in an endemic area in Colombia.Materials and methods: We conducted a cross-sectional study with 515 pupils (7-16 years old) in 34 rural schools in Anapoima and La Mesa municipalities during 2011. Each KAP category was evaluated independently by a scoring system and then categorized into high, medium or low.Results: Pupils recognized knowledge variables such as the symptoms (fever, bone pain), transmission route (mosquito bites), and mosquito breeding sites (uncovered water tanks, solid waste). Average scores on attitude were high in both municipalities indicating a well-developed perception of disease severity. Seeking treatment in medical centers and self-medication for fever management and the use of mosquito net and space-spraying of insecticides were the most frequently identified practices.Discussion: This is the first KAP dengue study performed in a rural area in Colombia and as such it contributes to the understanding of dengue perceptions by the inhabitants of these areas. It showed a medium level of knowledge about dengue and a lower level of preventive practices in pupils from rural schools. It also showed that pupils considered space-spraying as crucial for vector control. The presence of the vector in rural areas of the country underlines the need to improve surveillance and education to more effectively control the vector and promote prevention methods including community participation.
Evaluación del daño oxidativo y por metilación del ADN de pintores expuestos ocupacionalmente a solventes orgánicos y pinturas
Authors: Londoño-Velasco Elizabeth , Martínez-Perafán Fabián , Carvajal Silvio , García-Vallejo Felipe , Hoyos-Giraldo Luz Stella
Published: October 2019

Introducción. La exposición a solventes orgánicos y pinturas se ha asociado con efectos genotóxicos y mayor riesgo de neoplasias. Sin embargo, aún no se ha caracterizado bien el tipo de daño que esta exposición induce en el ADN humano, ni los mecanismos por los cuales se genera. Uno de los grupos con mayor exposición a dichos solventes y pinturas son los pintores de automóviles del sector informal que trabajan sin adecuadas prácticas de seguridad ocupacional.Objetivo. Determinar el daño oxidativo y por metilación del ADN de linfocitos de pintores de automóviles expuestos a solventes orgánicos y pinturas.Materiales y métodos. Se analizaron linfocitos aislados de sangre periférica de 62 pintores y 62 sujetos no expuestos mediante el ensayo cometa de gran eficiencia acoplado a las enzimas Fpg y AlkA. Las categorías de daño en el ADN evaluadas fueron el daño basal (sin enzimas), el daño oxidativo y el daño por metilación, y el parámetro de medición, el porcentaje de ADN en la cola.Resultados. El porcentaje de ADN en la cola fue mayor en el grupo expuesto con respecto al no expuesto (p<0,05). En el grupo expuesto, dicho porcentaje fue mayor en la categoría de daño oxidativo comparado con la del basal (16,50 Vs. 12,87; p<0,001), en tanto que en el daño por metilación no se encontraron diferencias significativas (14,00 Vs. 12,87; p>0,05).Conclusión. La exposición a solventes orgánicos y pinturas se asoció con el aumento de las lesiones oxidativas del ADN de los linfocitos de pintores de automóviles, tales como la producción de 8-oxo-2’-desoxiguanosina (8-oxodG) y otros productos formamidopirimidina, los cuales se consideran considerablemente mutagénicos.
Descripción clínico-radiológica de un angiosarcoma cardiaco con metástasis cerebral que simula un quiste hidatídico
Authors: Ortiz Blair , Hernández Carolina , Barajas Norma Carolina
Published: October 2019

Los angiosarcomas son sarcomas malignos que se originan en las células endoteliales vasculares. Su diagnóstico diferencial es muy amplio debido a su parecido con otras enfermedades, como las parasitarias, y usualmente es un diagnóstico por exclusión. La neurocisticercosis y la hidatidosis cerebral son parasitosis intestinales que pueden comprometer el sistema nervioso central y tienen mayor incidencia en los países suramericanos.El diagnóstico se establece a partir del perfil epidemiológico, el estudio parasitológico, la apariencia radiológica de las lesiones y el estudio de histopatología del espécimen.Se presenta el caso de una adolescente con factores de riesgo para parasitosis y neuroimágenes sugestivas de hidatidosis cerebral, cuyo diagnóstico definitivo fue angiosarcoma cardiaco metastásico.
Estudio de las variantes alélicas CYP2C9*2 y CYP2C9*3 en muestras de población mestiza peruana
Authors: Alvarado Ángel Tito , Muñoz Ana María , Loja Berta , Miyasato Jessica Michiko , García Jorge Antonio , Cerro Roberto Andrés , Quiñones Luis Abel , Varela Nelson Miguel
Published: October 2019

Introducción. El citocromo CYP2C9 metaboliza, aproximadamente, el 15 % de los fármacos prescritos. Su gen presenta alelos cuyas frecuencias difieren entre grupos étnicos y poblaciones. Los alelos CYP2C9*2 y CYP2C9*3 dan cuenta de una enzima con actividad disminuida cuya frecuencia no ha sido determinada en la población mestiza peruana.Objetivo. Caracterizar la frecuencia de las variantes *2 (rs1799853) y *3 (rs1057910) del gen CYP2C9 en muestras de población mestiza peruana provenientes de Lima, Tacna y Junín.Materiales y métodos. Se hizo un estudio descriptivo, observacional y prospectivo, con muestreo no probabilístico, por conveniencia e incidental. Se incluyeron 218 sujetos según los criterios de inclusión y exclusión; todos los participantes otorgaron su consentimiento informado. El ADN genómico se obtuvo mediante hisopado de mucosa oral, y la detección de los genotipos para los alelos CYP2C9*2 y CYP2C9*3 se hizo mediante reacción en cadena de la polimerasa (PCR) en tiempo real, utilizando sondas TaqMan™.Resultados. Las variantes de CYP2C9*2 y CYP2C9*3 están presentes en la población mestiza peruana con frecuencias de 0,046 y 0,062, respectivamente. El análisis de las frecuencias genotípicas observadas permitió predecir que la frecuencia de fenotipos metabolismo intermedio sería del 15,13 % (CYP2C9*1/*2: 5,96 %; CYP2C9*1/*3: 9,17 %), y la de fenotipos de metabolismo lento, del 3,22 % (CYP2C9*2/*2: 1,38 %; CYP2C9*3/*3: 1,38 %; CYP2C9*2/*3: 0,46 %).Conclusiones. Se lograron determinar las frecuencias genotípicas y alélicas para las variantes *2 y *3 del gen CYP2C9 en una muestra no probabilística de población mestiza peruana.
Establishment of an in vitro model of cultured viable human, porcine and canine skin and comparison of different media supplements
Authors: Bauhammer Isa , Sacha Manuel , Haltner Eleonore
Published: October 2019

Transdermal drug delivery provides several advantages over conventional drug administration, such as the avoidance of first-pass metabolism and better patient compliance. In vitro research can abbreviate and facilitate the pharmaceutical development considerably compared to in vivo research as drug screening and clinical studies can be reduced. These advantages led to the development of corresponding skin models. Viable skin models are more useful than non-viable ones, due to the influence of skin metabolism on the results. While most in vitro studies concentrate on evaluating human-based models, the current study is designed for the investigation of both human and animal diseases. So far, there is little information available in the literature about viable animal skin cultures which are in fact intended for application in the veterinary and not the human field. Hence, the current study aims to fill the gap. For the in vitro viable skin model, specimens of human, porcine and canine skin were cultured over two weeks under serum-free conditions. To evaluate the influence of medium supplementation on skin viability, two different supplement mixtures were compared with basic medium. The skin specimens were maintained at a viability-level >50% until the end of the study. From the tested supplements, the addition of bovine pituitary extract and epidermal growth factor increased skin viability whereas hydrocortisone and insulin induced a decrease. This in vitro viable skin model may be a useful tool for the investigation of skin diseases, especially for the veterinary field.
Resource-use Efficiency in Small Scale Broiler Production in Owerri Municipal Council of Imo State, Nigeria
Authors: Okwara M. O. , Umebali E. E. , Agu F. N. , Ukoha I. I. , Anyanwu U. G.
Published: October 2019

The study analyzed the resource use efficiency in small scale broiler production in Owerri Municipal Council of Imo State. Data were collected with well structured questionnaire from 40 randomly selected broiler farmers. The questionnaire were analyzed with the appropriate statistical and econometric tools. The result showed that the small scale broiler producers were profitable in the study area. Feed cost was very high consisting of 39.37% of the total cost and 44.63% of the variable cost of production. Farm size, labour, feed cost, medication are all important factors affecting the net revenue of the farmers in the study area. The net revenue of the broiler farmers was estimated at N140,989.56 per farmer per year implying that small scale broiler production is profitable. The farmers were inefficient in the use of resources such as land, labour, capital, feed, medication and other inputs. The benefit cost ratio was estimated at 2.22, implying that for every one naira invested in small scale broiler production in the study area, 11 kobo was gained thus profitable. The major constraints to small scale broiler production are lack of credit and the incidence of pest and diseases. Agricultural policies and programmes should focus on improving the farmers’ access to credit and appropriate technology the farmers’ access to credit and appropriate technology should be developed to reduce losses through the incidence of pest and diseases.
Effect of Crop Residues Management on Soil Properties and Crop Productivity of Rice-wheat System in Inceptisols of Seemanchal Region of Bihar
Authors: Singh Rama Kant , Sharma Girijesh Kumar , Kumar Pankaj , Singh S. K. , Singh Reeta
Published: October 2019

A field experiment was carried out at Krishi Vigyan Kendra, Katihar, Bihar in jurisdiction of Bihar Agricultural University Sabour, Bhagalpur during 2014 to 2018 with the objective to find out suitable crop residue management option under rice- wheat cropping system in Inceptisols of Seemanchal area of Bihar. The results after four years clearly indicates that the crop residue management practices involving  incorporation of residues improved favorably and significantly the soil properties such as bulk density, infiltration rate, mean weight diameter, aggregate stability, electrical conductivity, organic carbon, available nitrogen, phosphorus and potassium, bacterial and fungal population, enzyme dehydrogenase and phosphatase activity in the soil and increased the grain yields of rice and wheat crop in the system over removal or burning of crop residue practices. Due to increased availability of readily decomposable organic matter in the form of crop residue and freshly incorporated green manure, the microbial population increased dramatically when crop residues are incorporated in the soil which might be responsible for increased enzyme phosphatase and dehydrogenase activity, decrease in bulk density, increase in granulation and aggregation and thus infiltration rate. The incorporation of crop residues with or without green manuring found promising for the environmental friendly and effective utilization of the crop residues under prevailing rice wheat system in this area.
Effect of Different Type Mulch on Growth, Yield Attributes and Yield of Brinjal (Solanum melogena)
Authors: Kumar Ravi Ranjan , Singh Rajeev , . Nityanand , Sohane R. K. , Singh A. K.
Published: October 2019

Field experiment was conducted at Krishi Vigyan Kendra, Aurangabad and at farmer’s field during 2012 and 2013 to Effect of different type mulch on growth, yield attributes and yield of Brinjal (Solanum melogena). The experiment was conducted in randomized block design with three treatments viz; Black polyethylene mulch, Wheat straw mulch and no mulch (control). The result reveled that maximum plant height 78.0 cm, maximum no. of leaves per plant 366.8 and maximum number of shoots per plant 32.60 were observed in plot mulching with Black polyethylene. Maximum yield 29.5t/ha-1 of brinjal was obtained with black polyethylene mulch while, minimum yield recorded 16.5 t ha-1 in control plot. Wheat straw mulch recorded 50.30% more brinjal yield as compared with control. The benefit-cost ratio was highest (3.7) with black polythene mulch as compared to control which was (2.7). Economic comparison indicate that polythene mulch were more efficient than wheat straw mulch.
Bridging Bible and Biology: The Impact of Faith Integration on the Spiritual Growth of Students in Christian Higher Education
Authors: Savarirajan Daisy , Fong Su
Published: October 2019

The integration of faith and learning (IFL) is an integral part of Christian higher education. The recent years have seen a spate in published studies testifying to an intense pursuit of meaningful IFL by many institutions of Christian higher education. However, little scholarship has been devoted to explore the influence of faith integration in science and its effect on the spiritual growth of students. A private, Christian university in the Southwest United States, has integrated the Christian worldview (CWV) in at least 30% of courses in college programs. Instilling the core Christian convictions into each student’s total college life has been one of the distinctive tasks of the University. The purpose of this study is twofold: (1) to understand how CWV develops in Biology and (2) how IFL affects the personal faith of students. The data was collected, over a period of three consecutive years 2016 to 2018, from students preparing for Health Care and Science careers. Using the survey design with open-ended questions, 489 participants provided responses to articulate the Christian worldview perspective of microorganisms and diseases. Findings reveal a positive impact of IFL on the personal faith of students. The results also indicate students demonstrating growth in their understanding of the biblical worldview within the context of Biology.
Counselor Development as The Hero’s Journey: Reflections from a Counselor Educator
Authors: Kaufmann Daniel
Published: October 2019

The use of the monomyth to shape the narratives of fiction with deep meanings, while feeling both new and recognizable, is consistently experienced across all cultures throughout time. As past publications have utilized this approach to subconscious symbolism to explain many experiences, it has not yet been utilized to explain the process of counselor development. The structures utilized in this exploration of the Hero’s Journey concept include the seminal work Hero with a Thousand Faces by Joseph Campbell (1949) being applied to the structure of counseling development as reviewed by Rønnestad and Skovholt (2003). Each stage of the journey will be translated into an understanding of how students grow from before their master’s program through their senior years as experts in the counseling field. The following article will engage this metaphor to explore the narrative of a counseling student on their quest to become a counseling professional through use of the stages from the monomyth as used to describe the Hero’s Journey.
Being Thrown Under the Bus and Rising Above the Fray: Maintaining Authenticity
Authors: Quade Kristine , Beaver Amanda , Fry Laura , Bulmini Daniela , Miller Elvia
Published: October 2019

The qualitative descriptive study was conducted to explore how female leaders describe remaining authentic when being scapegoated. The participants were twelve senior female leaders in either for-profit or non-profit roles in Arizona. While not all women were able to maintain their authenticity during the scapegoating experience, the experience of scapegoating was transformational in finding their authentic self.
PERAN MEDIA AJAR DALAM PENDIDIKAN KEUANGAN PADA SISWA TAMAN KANAK-KANAK MELALUI PROGRAM SERVICE LEARNING MATA KULIAH PERSONAL FINANCE
Authors: Linawati Nanik
Published: October 2019

Pendidikan anak pada jenjang pendidikan Taman Kanak-kanak merupakan fondasi bagi pembentukan kepribadian pada jenjang usia berikutnya hingga dewasa. Salah satu materi pendidikan yang harus diberikan, yaitu pendidikan dalam mengelola uang, khususnya menanamkan kebiasaan menabung dan perasaan bangga pada kemampuan anak, karena memiliki kemampuan untuk membeli sesuatu yang diinginkan dari uang sendiri. Materi pendidikan yang juga penting untuk diberikan kepada siswa Taman Kanak-kanak, yaitu pengenalan terhadap uang sebagai instrumen transaksi sehari-hari. Media aktivitas yang dipilih untuk menanamkan kegemaran menabung melalui gerak dan lagu, cerita, panggung boneka, dan mewarnai. Sedangkan pengenalan terhadap uang disampaikan melalui media tutorial dengan menggunakan peraga dan role playing (bermain peran).
PEMBANGUNAN SMOKING AREA UNTUK MENINGKATKAN KUALITAS HIDUP MASYARAKAT DI KAWASAN EKS-LOKALISASI DOLLY
Authors: Hermawan Surya , Purnomo Joko , Prayogo Handy , Handoyo Hans , Setiawan Jonathan
Published: October 2019

Asap rokok mengandung banyak zat berbahaya bagi tubuh manusia, terutama bagi perokok aktif. Namun, berdasarkan penelitian beberapa tahun belakangan ini, dampak yang sama ditimbulkan oleh asap rokok kepada orang yang tidak merokok—perokok pasif (passive smoking). Lebih lanjut, tidak terkendalinya peredaran rokok menyebabkan tren merokok di tempat umum merajalela. Fenomena serupa seperti seseorang merokok di dalam rumah, kantor, tempat umum, bahkan di kendaran umum terlihat jelas di kawasan Eks-Lokalisasi Dolly, Kelurahan Putat Jaya, Kota Surabaya, Jawa Timur. Perilaku tersebut membawa dampak negatif bagi lingkungan, terutama bagi ibu-ibu dan anak-anak sebagai perokok pasif (passive smoker). Untuk mengurangi dampak negatif perilaku passive smoking diperlukan sebuah tindakan nyata untuk menyadarkan masyarakat untuk hidup sehat dan bebas dari asap rokok. Paper ini membahas tentang kegiatan pengabdian kepada masyarakat berbasis service learning dengan hasil nyata berupa pembangunan smoking area. Kegiatan pengabdian kepada masyarakat ini melibatkan 120 Mahasiswa Program Studi Teknik Sipil Universitas Kristen Petra. Proses pengabdian kepada masyarakat ini dilaksanakan dalam tiga tahap, meliputi prapelaksanaan, pelaksanaan pembangunan smoking area, dan paska pelaksanaan. Berdasarkan hasil akhir yang dicapai, program ini dinilai berhasil meningkatkan kesadaran masyarakat untuk hidup sehat dan bebas dari asap rokok, serta menjadikan smoking area sebagai tempat berkumpul dan berdiskusi untuk melakukan hal-hal positif.
RESPON EKOLOGIS DAN KREATIF BEBAN LIMBAH FURNITUR RUSAK DI INSTITUSI PENDIDIKAN
Authors: Evelin Monika , Angelina Feliecia , Kusumarini Yusita
Published: October 2019

Limbah furnitur rusak di institusi pendidikan adalah permasalahan rutin yang cukup menjadi beban bagi pengelola sarana prasarana di institusi pendidikan. Sebagai studi kasus dalam bahasan ini adalah menumpuknya furnitur rusak di Universitas Kristen Petra.Isu tersebut menjadi materi kasus yang dipilih dan perlu diselesaikan dalam mata kuliah Eko-Desain Program Studi Desain Interior, Universitas Kristen Petra pada tahun 2018. Fenomena menumpuknya furnitur rusak di gudang UPPK (Unit Pemeliharaan dan Pelayanan Kampus) dipandang sebagai bagian dari permasalahan lingkungan kampus yang perlu diresponi secara ekologis dan kreatif. Respon terhadap permasalahan tersebut diproseskan dalam kegiatan pembelajaran dengan melibatkan mahasiswa dan pemangku kepentingan, dengan pendekatan design thinking dan metode service-learning. Hasil dari proses pembelajaran tersebut adalah 21 produk kreatif berupa furnitur baru untuk memenuhi kebutuhan aktivitas di kampus
Políticas socioculturales en Uruguay: la cultura como medio, como fin, como derecho ¿Qué piensan los gestores?
Authors: Simonetti Paula
Published: October 2019

Na última década, o Uruguai desenvolveu uma série de políticas culturais para populações vulneráveis, historicamente relegadas de seus direitos culturais. Essas iniciativas também dialogam com um contexto transnacional em que a relação entre cultura e desenvolvimento social é ressignificada, bem como a posição que os Estados ocupam nela. O objetivo deste artigo é compreender as representações que trabalhadores e operadores de cultura constroem nesse campo de políticas recentes. Veremos que o paradigma dos direitos culturais é um terreno onde há sentidos e práticas heterogêneas, que às vezes estão em conflito
Inovações na Política Cultural e no Desenvolvimento na América Latina
Authors: Yúdice George
Published: October 2019

Este ensaio analisa duas tendências principais nas recomendações das políticas culturais na América Latina: 1) a contribuição econômica das artes, do patrimônio e especialmente das indústrias culturais e criativas; 2) direitos culturais, com foco na inclusão, acesso, empoderamento e desenvolvimento integral / bem-estar dos cidadãos. As duas tendências, que fazem parte das políticas de desenvolvimento cultural, não são facilmente integradas a uma política abrangente, pois seguem diferentes lógicas e estratégias de gestão. Não obstante, ambas as tendências, que emergiram no auge do neoliberalismo (década de 1990), continuam a fornecer as principais justificativas para o financiamento cultural, embora a atual crise econômica tenha levado a cortes orçamentários. Após uma revisão das políticas de desenvolvimento cultural, este ensaio examina estratégias inovadoras para compensar os recursos escassos, incluindo aqueles que procuram unir ambas as tendências. Os casos examinados abaixo correspondem a discussões de políticas culturais em fóruns latino-americanos com centenas de formuladores de políticas e analistas nos últimos vinte anos.
Infância e o paradigma da proteção integral: reflexões sobre direitos e situação de trabalho
Authors: Santos Ana Katia Alves , Queiroz Adriana Franco
Published: October 2019

O presente artigo objetiva apresentar reflexões e análises compartilhadas por pesquisadoras e profissionais com história de atuação no campo da primeira infância e na formação de professores. O mesmo dá destaque para a concepção de criança como sujeito de direitos e o paradigma da proteção integral que lhe dá sustentação, mas conhecido como Estatuto da Criança e do Adolescente (ECA) e os seu complemento, voltado para crianças pequenas, a saber o Marco Legal da Primeira Infância. Destaca também a Base Nacional Comum Curricular (BNCC) no que tange a Educação Infantil. Apesar de leis e declarações de significado, no entanto, o artigo sistematizou resultado que chama atenção para a violação dos direitos da criança, dando especial atenção à uma dessas violações tão presente no cotidiano brasileiro: o trabalho infantil. O texto finaliza com debate sobre o papel das instituições infantis (escola) no diagnóstico, prevenção e denúncia de abusos que levam a violação dos direitos infantis. A metodologia se baseou em pesquisa de natureza qualitativa, desenvolvidas pelas autoras em seus estudos acadêmicos, bem como na prática profissional no campo da Educação desde a Primeira infância e formação de professores. A fundamentação teórica se sustentou em ARIÈS(1981), FONSECA(1993), FUGYMOTO(2016), PEEN(2002), QUEIROZ(2002), SANTOS(2017;2006), ROMANOWSKY(2015) e documentos oficiais atuais (ECA, BNCC, Marco Legal da Primeira Infância).
Docência na Educação Infantil: entrelaçamentos entre a formação inicial e a prática pedagógica
Authors: Dos Santos Marlene Oliveira , Franco Nanci Helena Rebouças , Varandas Daniela Nascimento
Published: October 2019

O presente artigo discute a docência na Educação Infantil (EI) e busca evidenciar, numa perspectiva crítica, as interfaces e os dilemas entre a formação inicial e a prática pedagógica com crianças de 0 a 5 anos e 11 meses de idade no cotidiano de escolas de Educação Infantil. Tomou-se os estudos de Rosemberg (1999), Rocha (1999), Kishimoto (1999; 2002), Kramer (2002; 2005), Gatti (2010; 2011), Santos (2017), Tardif (2002; 2005), Tardos e Szanto-Feder (2011), Rinaldi (2016), Martins Filho e Delgado (2016) e as narrativas de cinco professoras da rede pública e privada de Salvador que exercem a docência na EI para analisar entrelaçamentos entre a formação e a prática pedagógica. Do ponto de vista teórico-metodológico, parte-se de uma abordagem qualitativa de cunho exploratório, com a utilização de pesquisa bibliográfica e entrevista. Entre os achados da pesquisa destacam-se a formação como uma das estratégias para a consolidação da qualidade da Educação Infantil, a compreensão da criança como aquela que nutre os sentidos do ser professor e a demanda de uma didática da Educação Infantil que coloque a criança no centro do planejamento curricular e a considere como um sujeito de direitos, competente, rico de iniciativas e de curiosidades. Conclui-se que a docência na Educação Infantil ainda é experienciada pelos professores e pelas crianças em contextos desafiantes, tanto do ponto de vista da intencionalidade e do alcance das políticas públicas de formação de professores como das complexidades da prática pedagógica.
O desenvolvimento do brincar em crianças com a Síndrome Congênita do Zika Vírus
Authors: Fernandes Márcia Pires , Ribeiro Silvanne , De Queiroz Fernanda Matrigani Mercado Gutierres
Published: October 2019

Pela perspectiva educacional inclusiva todas as crianças têm direito a educação, independentemente de sua condição socioeconômica, cultural ou deficiência. Tendo em conta tal perspectiva, o presente trabalho objetivou analisar a importância do brincar para o desenvolvimento das crianças com a Síndrome Congênita do Zika Vírus (SCZKV) na visão das progenitoras. Destaca-se ainda os objetivos: perceber os aspectos do desenvolvimento da criança por meio das brincadeiras que realiza e identificar a opinião das progenitoras sobre o papel das brincadeiras na aprendizagem e suas percepções acerca da inserção escolar dessas crianças. Para responder aos questionamentos foi realizado um estudo de campo com a participação das progenitoras através de um questionário, além da observação das crianças brincando durante gravações de um vídeo. Assim, emergiram as seguintes categorias de análise: 1) o brincar da criança com SCZKV; 2) o desenvolvimento da criança por meio da brincadeira e 3) a visão das progenitoras em relação a aprendizagem das crianças por intermédio das brincadeiras e a futura inserção escolar. Dessa forma, destaca-se o quanto é importante fazer um trabalho lúdico dentro de contextos de desenvolvimentos, podendo ser necessário adaptações na metodologia, nos recursos, materiais e atividades realizadas para a obtenção de uma resposta as necessidades de aprendizagem da criança com SCZKV. Conclui-se que o brincar estreita vínculos e traz benefícios para o processo de desenvolvimento, contudo a percepção das progenitoras sobre a escola inclusiva revelou inseguranças e receios ao que tange a inserção das crianças pequenas nas escolas de Educação Infantil.
Oncogenic Ras mutant causes the hyperactivation of NF‐κB via acceleration of its transcriptional activation
Authors: Tago Kenji , Funakoshi‐Tago Megumi , Ohta Satoshi , Kawata Hirotoshi , Saitoh Hiroshi , Horie Hisanaga , Aoki‐Ohmura Chihiro , Yamauchi Junji , Tanaka Akira , Matsugi Jitsuhiro , Yanagisawa Ken
Published: October 2019

It is well established that nuclear factor κB (NF‐κB) acts as one of the most important transcription factors for tumor initiation and progression, as it both protects cells from apoptotic/necrotic signals and accelerates angiogenesis and tumor metastasis, which is mediated via the expression of target genes. However, it has not yet been clarified how oncogenic signals accelerate the activation of NF‐κB. In the current study, we utilized untransformed NIH‐3T3 cells stably harboring a κB‐driven luciferase gene to show that an oncogenic mutant of Ras GTPase augmented TNFα‐induced NF‐κB activation. Notably, enforced expression of cyclin‐dependent kinase inhibitors, such as p27Kip1 and p21Cip1, effectively canceled the accelerated activation of NF‐κB, suggesting that oncogenic Ras‐induced cell cycle progression is essential for the hyperactivation of NF‐κB. Furthermore, we found that Ras (G12V) augmented the transcriptional activation of NF‐κB, and this activation required the p38 MAP kinase. We observed that a downstream kinase of p38 MAP kinase, MSK1, was activated by Ras (G12V) and catalyzed the phosphorylation of p65/RelA at Ser‐276, which is critical for its transcriptional activation. Significantly, phosphorylation of the p65/RelA subunit at Ser‐276 was elevated in patient samples of colorectal cancer harboring oncogenic mutations of the K‐Ras gene, and the expression levels of NF‐κB target genes were drastically enhanced in several cancer tissues. These observations strongly suggest that oncogenic signal‐induced acceleration of NF‐κB activation is caused by activation of the p38 MAP kinase–MSK1 signaling axis and by cell cycle progression in cancer cells.
Aerosol Jet Printed Polymer Composite Electrolytes for Solid‐State Li‐Ion Batteries
Authors: Deiner L. Jay , Jenkins Thomas , Howell Thomas , Rottmayer Michael
Published: October 2019

Solid‐state lithium‐ion (Li‐ion) batteries are a next generation energy storage technology that is able to address the transportation sector's need for increased safety and power density. Realizing this capability requires development of scalable manufacturing methods for solid electrolyte materials and for integration of such materials into battery cells. Herein, the first demonstration of aerosol jet printing is provided, which is a manufacturing‐ready 3D printing technique for fabrication of Li‐ion conducting solid polymer composite electrolytes. Deposition is performed directly on LiFePO4 cathode substrates. Aerosol jet printed electrolytes composed of polyethylene oxide (PEO), lithium difluoro(oxalato)borate (LiDFOB), and alumina nanoparticles are smooth, conformal, and nonporous, whereas those composed of PEO, lithium trifluoromethanesulfonate (LiTriflate), and alumina nanoparticles are conformal and porous. Conductivity of the printed solid polymer electrolytes tracks salt anion identity and concentration. The most conductive printed electrolyte, PEO/LiDFOB/alumina (EO:Li = 10:1), achieves conductivity >1 × 10−5 S cm−1 at 45 °C. In half cell configuration, batteries with this printed electrolyte can be discharged at C/15 with capacity >85 mAh g−1 at 45 °C and >160 mAh g−1 at 75 °C. The achievement of aerosol jet printed solid polymer composite electrolytes opens a path for scalable manufacturing of solid‐state Li‐ion batteries.
Improving the Mechanical Property of Dissimilar Al/Mg Zn‐Added Ultrasound‐Assisted Friction Stir Lap Welding Joint by Back Propagation Neural Network–Gray Wolf Optimization Algorithm
Authors: Song Qi , Ren Zhaoxu , Ji Shude , Niu Shiyu , Qi Weiwei , Chen Mingfei
Published: October 2019

Process parameters of rotating velocity, welding speed, Zn interlayer thickness, and ultrasound power are optimized by the hybrid of back propagation neural network (BPNN) and gray wolf optimization algorithm (GWOA) to obtain a high‐quality Zn‐added ultrasound‐assisted friction stir lap welding joint of 7075‐T6 Al/AZ31B Mg dissimilar alloys. The results state that the prediction accuracy of the trained BPNN model is acceptable. The optimal process parameters combination is obtained by the GWOA which is combined with the trained BPNN. The verification tests are performed under the executable optimal solution, which consists of the rotating velocity of 1054 rpm, the welding speed of 54 mm min−1, the Zn interlayer thickness of 0.05 mm, and the ultrasound power of 1568 W. The tensile shear load of the joint reaches 9.05 kN, and the strength is 11.8% larger than that of the reported optimal joint. The artificial intelligence optimization method of GWOA combined with BPNN can accurately predict and optimize the joint strength, which has great time and economic advantages.
Too Big Too Fast? Potential Implications of the Rapid Increase in Emergency Medicine Residency Positions
Authors: Haas Mary R. C. , Hopson Laura R. , Zink Brian J.
Published: October 2019

Emergency medicine (EM) has expanded rapidly since its inception in 1979. Workforce projections from current data demonstrate a rapid rise in the number of accredited EM residency programs and trainee positions. Based on these trends, the specialty may soon reach a point of saturation, particularly in urban areas. This could negatively impact future trainees entering the job market as well as the career plans of medical students. More time and resources should be devoted to obtaining accurate projections, assessing the distribution of emergency physicians in rural versus urban settings, and implementing central workforce planning to protect the future of graduating trainees.
RETRACTED: Soyasapogenol B Attenuates Laryngeal Carcinoma Progression through Inducing Apoptotic and Autophagic Cell Death
Authors: Zhi Lili , Song Daoliang , Ma Liji , Feng Tao
Published: October 2019

Soyasapogenol B (Soy B), a constituent of soybean, has been shown to exhibit antitumor activities against different types of cancers. However, to our knowledge, no studies so far have investigated the effect of Soy B in human laryngeal carcinoma. This study, therefore, aimed to determine the effect of Soy B in human laryngeal carcinoma cell lines HeP‐2 and TU212 and to elucidate the possible underlying mechanisms by which Soy B can induce its antitumor effects. The results showed that Soy B effectively attenuated the cell growth by causing G0/G1 phase cell cycle arrest in laryngeal carcinoma cell lines. Moreover, the percentage of apoptotic and autophagic cells dramatically increased upon exposure to Soy B. Western blotting results confirmed that Soy B can alter the expression levels of established markers of apoptosis and autophagy. Interestingly, both apoptosis inhibitor (ZVAD‐fmk) and autophagy inhibitor (3‐MA) could partially reverse the effect of Soy B, while blocking autophagy did not cause obvious alteration in the percentage of apoptotic cells. Similarly, in vivo studies validated that Soy B could effectively reduce the size of the tumor and induce apoptosis and autophagy in tumor tissues. Collectively, these results suggested that Soy B can exert anticancer activities against laryngeal carcinoma through inducing apoptotic and autophagic cell death. Our study highlighted the potential role of Soy B as a chemotherapeutic agent for laryngeal carcinoma. Anat Rec, 2019. © 2019 American Association for Anatomy Anat Rec, 303:1851–1858, 2020. © 2019 American Association for Anatomy
Effects of curcumin on mitochondria in neurodegenerative diseases
Authors: Bagheri Hossein , Ghasemi Faezeh , Barreto George E. , Rafiee Rouhullah , Sathyapalan Thozhukat , Sahebkar Amirhossein
Published: October 2019

Neurodegenerative diseases (NDs) result from progressive deterioration of selectively susceptible neuron populations in different central nervous system (CNS) regions. NDs are classified in accordance with the primary clinical manifestations (e.g., parkinsonism, dementia, or motor neuron disease), the anatomic basis of neurodegeneration (e.g., frontotemporal degenerations, extrapyramidal disorders, or spinocerebellar degenerations), and fundamental molecular abnormalities (e.g., mutations, mitochondrial dysfunction, and its related molecular alterations). NDs include the Alzheimer disease and Parkinson disease, among others. There is a growing evidence that mitochondrial dysfunction and its related mutations in the form of oxidative/nitrosative stress and neurotoxic compounds play major roles in the pathogenesis of various NDs. Curcumin, a polyphenol and nontoxic compound, obtained from turmeric, has been shown to have a therapeutic beneficial effect in various disorders especially on the CNS cells. It has been shown that curcumin has considerable neuro‐ and mitochondria‐protective properties against broad‐spectrum neurotoxic compounds and diseases/injury‐associating NDs. In this article, we have reviewed the various effects of curcumin on mitochondrial dysfunction in NDs.