bluuebunny/crossref_metadata_2025 huggingface dataset:
Clickable Bifunctional and Vertically Aligned Mesoporous Silica Films
Authors: Vilà Neus , Ghanbaja Jaafar , Walcarius Alain
Published: November 2015

Getting oriented mesoporous thin films with functionalized pores accessible from the substrate surface remains one key challenge in materials science, and jumping the step forward to multifunctional layers with perpendicular nanochannels has still to be achieved. Here, a general method is introduced combining the electrochemically assisted deposition of ordered and oriented azide‐ and thiol‐functionalized mesoporous silica with a selective sequential azide‐alkyne and thiol‐ene “click chemistry” approach to prepare nanostructured and vertically aligned hybrid films bearing tunable amounts of organo‐functional groups. High‐resolution electron microscopy is used to evidence the high level of mesostructural order and pore orientation, while the effectiveness of the functionalization processes is proven from spectroscopic and electrochemical measurements. Voltammetric data also demonstrate that both the accessibility through the films and the properties of the incorporated functions are maintained upon derivatization. Feasibility of this simple and generic strategy is illustrated here for two couples of model derivatives (ethynylcobaltocenium/vinylferrocene and propargyl alcohol/allyl cyanide) but such stepwise postfunctionalization can be extensively used for the incorporation of a variety of organic functions in mesoporous silica films.
Palladium‐Catalyzed Formation of N‐Heteroarenes from Nitroarenes using Molybdenum Hexacarbonyl as the Source of Carbon Monoxide
Authors: Zhou Fei , Wang Duo‐Sheng , Driver Tom G.
Published: November 2015

The development of a method that employs a two‐chamber reaction vessel and uses molybdenum hexacarbonyl [Mo(CO)6] as the carbon monoxide (CO) source for the palladium‐catalyzed transformation of nitroarenes into indoles or imidazoles is reported. The scope and limitations of our method are illustrated with 23 examples. Experiments that indicate the mechanism of the CH bond amination reaction to be stepwise are also reported.

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Nanoskalige Oberflächenstrukturierung mittels Atomlagenabscheidung
Authors: Sobel Nicolas , Hess Christian
Published: November 2015

Das Interesse an der kontrollierten Strukturierung von Oberflächen ergibt sich aus einer Vielzahl von Bereichen, welche die mikroelektronische Bauelementherstellung, optische Geräte, Biosensorik, (Elektro‐, Photo‐)Katalyse, Batterien, Solarzellen, Brennstoffzellen und Sorption einschließen. Ein einzigartiges Merkmal der Atomlagenabscheidung (ALD) besteht darin, dass konforme, gleichmäßige Beschichtungen auf beliebig geformten Materialien mit kontrollierten atomaren Schichtdicken erhalten werden können. In diesem Kurzaufsatz diskutieren wir das Potenzial der ALD zur nanoskaligen Strukturierung von Oberflächen und betonen dabei die vielseitigen Anwendungen im Hinblick auf die Strukturierung planarer und pulverförmiger Substrate. Berücksichtigt man die jüngsten Fortschritte bei der Anwendung der ALD auf poröse Substrate, ist nun sogar die nanoskalige Strukturierung von Materialien mit großer spezifischer Oberfläche realisierbar. Dies ermöglicht neuartige Anwendungen, beispielsweise auf den Gebieten der Katalyse und der regenerativen Energien.
Ein Auxiliartyp für die native chemische Peptidligation jenseits von Cystein und Glycin
Authors: Loibl Simon F. , Harpaz Ziv , Seitz Oliver
Published: November 2015

Um den Anwendungsbereich der nativen chemischen Ligation über N‐terminale Cysteinreste hinaus zu erweitern, wurden bislang thiolfunktionalisierte Auxiliare verwendet. Allerdings sind die Reaktionsgeschwindigkeiten mit den bisher eingesetzten Auxiliaren vom N‐Benzyl‐Typ eher gering. Um die Bindungsspaltung durch eine radikalische Fragmentierungsreaktion zu initiieren, wurde nun ein neues Auxiliar entwickelt, das in Gegenwart von TCEP und Morpholin unter mild basischen Bedingungen (pH 8.5) abgespalten wird. Das 2‐Mercapto‐2‐phenethyl‐Auxiliar ist anders als früher beschriebene Auxiliare nicht auf glycinhaltige Schnittstellen beschränkt, sondern ermöglicht auch sterisch anspruchsvolle Peptidligationen. Das Auxiliar wird in hoher Ausbeute durch reduktive Aminierung mit kommerziell erhältlichen Aminosäurebausteinen an der Festphase eingeführt. Der präparative Nutzen der Methode wird durch die Synthese der antimikrobiellen Proteine DCD‐1L und Opistoporin‐2 demonstriert.
Application of a fluorescent biosensor based‐on magneto‐γ‐Fe2O3–methyldopa nanoparticles for adsorption of human serum albumin
Authors: Shahabadi Nahid , Maghsudi Maryam , Shiri Farshad
Published: November 2015

Understanding and controlling the interaction between the polymer methyldopa (2‐amino‐3‐(3,4‐dihydroxyphenyl)‐2‐methyl‐propanoic acid) (PMDP)–γ‐Fe2O3 nanoparticles and biological fluids is important if the potential of nanoparticles (NPs) in biomedicine is to be realized. Physicochemical studies on the interactions between proteins and NPs are influenced by the surface properties of the NPs. To identify the effects of the NP surface, interactions between human serum albumin (HSA) and PMDP–γ‐Fe2O3 NPs were investigated. Here, the adsorption of HSA onto small (10–30 nm diameter) PMDP–γ‐Fe2O3 NPs was quantitatively analyzed using spectroscopic methods. The fluorescence quenching data were checked for the inner‐filter effect, the main confounding factor in the observed quenching. The binding constants, Ka, were calculated at different temperatures, using a nonlinear fit to the experimental data, and the thermodynamic parameters ∆H, ∆S and ∆G were given. The obtained thermodynamic signature suggests that hydrophobic interactions at least are present. This result indicates that the structure of the protein turns from a structureless denatured state at pH 3 into an ordered biologically active native state on addition of PMDP–γ‐Fe2O3 NPs. Copyright © 2015 John Wiley & Sons, Ltd.
Subcutaneous fat necrosis of the newborn
Authors: Rubin Giulia , Spagnut Giulia , Morandi Francesco , Valerio Enrico , Cutrone Mario
Published: November 2015

Key Clinical Message

Subcutaneous fat necrosis (SCFN) is a rare fat tissue inflammation of the newborn. Risk factors include cord prolapse, perinatal asphyxia, therapeutic hypothermia, meconium aspiration, and sepsis. When present, hypercalcemia comes with lethargy, hypotonia, irritability, vomiting, polyuria, polydipsia, constipation, and dehydration. Kidney injury must be avoided. SCFN is often completely autoresolutive.
Elderly‐onset degenerative “lumbar spondylotic myelopathy” in a patient with a low‐placed spinal cord successfully treated by laminotomy: a case report
Authors: Hashimoto Ko , Tsubakino Takumi , Hoshikawa Takeshi , Nakagawa Tomowaki , Inawashiro Takashi , Kokubun Shoichi , Itoi Eiji , Tanaka Yasuhisa
Published: November 2015

Key Clinical Message

The authors report a rare case of elderly‐onset “lumbar spondylotic myelopathy” occurred on a low‐placed spinal cord compressed at multiple levels with thickened ligamenta flava. A posterior decompression surgery could alleviate neurological symptoms successfully instead of untethering of the spinal cord, a widely accepted surgery for tethered cord.
Superior Electrochemical Properties of Nanofibers Composed of Hollow CoFe2O4 Nanospheres Covered with Onion‐Like Graphitic Carbon
Authors: Hong Young Jun , Cho Jung Sang , Kang Yun Chan
Published: November 2015

Nanofibers composed of hollow CoFe2O4 nanospheres covered with onion‐like carbon are prepared by applying nanoscale Kirkendall diffusion to the electrospinning process. Amorphous carbon nanofibers embedded with CoFe2@onion‐like carbon nanospheres are prepared by reduction of the electrospun nanofibers. Oxidation of the CoFe2‐C nanofibers at 300 °C under a normal atmosphere produces porous nanofibers composed of hollow CoFe2O4 nanospheres covered with onion‐like carbon. CoFe2 nanocrystals are transformed into the hollow CoFe2O4 nanospheres during oxidation through a well‐known nanoscale Kirkendall diffusion process. The discharge capacities of the carbon‐free CoFe2O4 nanofibers composed of hollow nanospheres and the nanofibers composed of hollow CoFe2O4 nanospheres covered with onion‐like carbon are 340 and 930 mA h g−1, respectively, for the 1000th cycle at a current density of 1 A g−1. The nanofibers composed of hollow CoFe2O4 nanospheres covered with onion‐like carbon exhibit an excellent rate performance even in the absence of conductive materials.
Azaphilic versus Carbophilic Coupling at CN Bonds: Key Steps in Titanium‐Assisted Multicomponent Reactions
Authors: Roth Torsten , Wadepohl Hubert , Clot Eric , Gade Lutz H.
Published: November 2015

Consecutive C‐ and N‐arylation of N‐heterocyclic nitriles is mediated by titanium(IV) alkoxides. The carbo‐ and azaphilic arylation step may be separated by choosing the order in which the two equivalents of aryl transfer reagent are added. In the course of this transformation, the ancillary N‐heterocycle acts as both a directing anchor group and electron reservoir. In the selectivity‐determining step, the selectivity is governed by a choice between (direct) C‐ and Ti‐arylation; the latter opens up a reaction pathway that allows further migration to the nitrogen atom. The isolation of metal‐containing aggregates from the reaction mixture and computational studies gave insights into the reaction mechanism. Subsequently, a multicomponent one‐pot protocol was devised to rapidly access complex quaternary carbon centers.
Flocculation with Lysozyme: A Non‐Enzymatic Application
Authors: Bonilla T. Sofia , Allen D. Grant
Published: November 2015

Bioflocculants have been previously recognized as an alternative to synthetic polymers due to their renewable sources and biodegradability. In this study, the flocculating activity of lysozyme on kaolin suspensions was investigated and compared to a known flocculant, a cationic polyacrylamide. Lysozyme was found to significantly aid in the flocculation of kaolin particles. The flocculating activity of lysozyme on kaolin was affected by the pH of the suspensions, while the addition of Mg2+ and Ca2+ ions did not have a significant effect. Potential industrial applications such as the flocculation of powdered activated carbon and algae suspensions were investigated and the addition of lysozyme resulted in significant flocculation. Furthermore, the flocculating properties of lysozyme are independent of its enzymatic activity. Our results indicate that lysozyme acts as a low molecular mass cationic polymer, where the main mechanism for flocculation on negatively‐charged particles is charge neutralization. Other cationic proteins could potentially be used as bioflocculants to enhance solid‐liquid separation.
Toxicity of Arsenic to Photobacterium phosphoreum, Daphnia magna, and Danio rerio at Different pH Levels
Authors: He Qun , Qu Ruijuan , Wang Xinghao , Wei Zhongbo , Sun Ping , Wang Zunyao
Published: November 2015

Although it has been widely known that arsenic poses great threat to organisms and arsenic species account for the toxic effect of the metalloid, relatively little attention has been given to the arsenic toxicity to different organisms at different pH values. Three kinds of aquatic organisms including Photobacterium phosphoreum, Daphnia magna, and Danio rerio were used to study the effects of pH on the toxicity of arsenic. Toxicity test results were analyzed by calculating EC50 values and for arsenic species at five different pH values (5.0, 6.0, 7.0, 8.0, and 9.0). As a result, As(III) is more toxic to the tested organisms than As(V), and P. phosphoreum was more sensitive to the toxicity of arsenic than D. magna and D. rerio. The toxicity of As(III) species is different for different organisms: dihydrogen arsenite, H2AsO3–, is more toxic to P. phosphoreum and D. rerio than arsenous acid, H3AsO3, while H3AsO3 is more toxic to D. magna. As for As(V), arsenate, HAsO42−, is the most toxic to P. phosphoreum, whereas dihydrogen arsenate, H2AsO4–, may be responsible for the toxicity to D. magna and D. rerio. As(III) and As(V) are more toxic to P. phosphoreum in an alkaline environment, while for D. magna in an acidic environment and As(III) is more toxic to D. rerio in an alkaline environment and As(V) in an acidic environment.
NIR‐to‐NIR Two‐Photon Scanning Laser Microscopy Imaging of Single Nanoparticles Doped by YbIII Complexes
Authors: Bourdolle Adrien , D'Aléo Anthony , Philippot Cécile , Baldeck Patrice L. , Guyot Yannick , Dubois Fabien , Ibanez Alain , Andraud Chantal , Brasselet Sophie , Maury Olivier
Published: November 2015

The photophysical and nonlinear optical properties of water‐soluble chromophore‐functionalised tris‐dipicolinate complexes [LnL3]3− (Ln=Yb and Nd) are thoroughly studied, revealing that only the YbIII luminescence can be sensitized by a two‐photon excitation process. The stability of the complex in water is strongly enhanced by embedding in dispersible organosilicate nanoparticles (NPs). Finally, the spectroscopic properties of [NBu4]3[YbL3] are studied in solution and in the solid state. The high brightness of the NPs allows imaging them as single objects using a modified two‐photon microscopy setup in a NIR‐to‐NIR configuration.
Toward a cure for HIV—Seeking effective therapeutic vaccine strategies
Authors: Autran Brigitte
Published: November 2015

This review article focuses on the rationale and evaluation of therapeutic vaccines against HIV. This strategy has been developed in order to restore or restimulate HIV‐specific immunity in patients treated with antiretroviral therapies. Despite the lack of good candidate vaccines against HIV, two objectives have been targeted during the past 15 years. Therapeutic immunization was first proposed to help control virus relapses during treatment interruptions. More recently, the concept of therapeutic immunization has been boosted by efforts to reach HIV remission or cure, in combination to HIV reactivating agents, to help purge HIV reservoirs in a “shock and kill” strategy. This review analyses the rationales for these strategies and the results of the most widely therapeutic vaccines designed to generate T‐cell immunity, i.e. recombinant viral vectors and dendritic cell‐based strategies, while extremely few strategies targeted HIV‐specific Abs. Only marginal control of HIV was obtained with cellular‐based strategies, suggesting that approaches targeting or using broadly neutralizing Abs, should be of benefit for future efforts of therapeutic immunization against HIV in the quest toward a cure for HIV.
Analytical approaches for measuring pesticides, mycotoxins and heavy metals in vegetable oils: A review
Authors: Ma Fei , Wu Rao , Li Peiwu , Yu Li
Published: November 2015

Nowadays, consumers are concerned about the toxicological implications and in a great demand for more information about the presence of organic residues and contaminants in vegetable oils. Pesticide residues, mycotoxins, and heavy metals can be readily accumulated in vegetable oil during the cultivation, processing and storage. Those chemical contaminants or its metabolites are carcinogenic, teratogenic, and immunotoxic, which result in serious damages to human health. With public health and economic losses considered, many analytical methods have been reported for the determination of chemical contaminants in vegetable oils. The aim of this review is to provide an update on the historical and current methods for the determination of contaminants in oil samples, discuss and evaluate the features, advantages and limitations, and finally outline the prospects for the multi‐class chemical contaminants determination in vegetable oils.

Practical applications: Different strategies and advantages of analytical methods for determination of chemical contaminants in vegetable oils are discussed and evaluated. The features and the prospects are useful for the development of the multi‐class methodology in lipid matrix.

Vegetable oils are widely used for cooking and processing in the food industry, meeting dietary demands. Major chemical contaminants, such as pesticide residues, mycotoxins, and heavy metals, are commonly found in vegetable oils. In this review, we provide an update on the historical and current methods for the determination of contaminants in oil samples, discuss and evaluate different analytical methods and techniques, and finally outline the prospects for the determination of major chemical contaminants in vegetable oils.
An Enantiopure 5,5′‐Bitetracene
Authors: Toyota Shinji , Miyaji Ryutaro , Yamamoto Yuta , Inoue Masataka , Wakamatsu Kan , Iwanaga Tetsuo
Published: November 2015

Two 5,5′‐bitetracene derivatives were synthesized from tetracenone in three steps as novel axially chiral biaryls. The enantiomers of 12,12′‐bis(phenylethynyl) derivative were successfully resolved by chiral HPLC. Their absolute stereochemistry was determined by theoretical calculations of the CD spectra using the time‐dependent (TD) DFT method.
Proliferative events and apoptotic remodelling in retinal development of common toad (Bufo bufo)
Authors: Pinelli Claudia , Sansone Alfredo , De Maio Anna , Morgillo Antonietta , Scandurra Anna , D'Aniello Biagio
Published: November 2015

Proliferation and apoptosis are fundamental processes in the development of the retina, and a proper balance of the two phenomena is crucial to correct development of the organ. Despite intense investigation in different vertebrates, only a few studies have analyzed the cell death and the cell division quantitatively in the same species during development. Here we studied the time course of apoptosis and proliferation in the retina of common toad, Bufo bufo, and discuss the findings in an evolutionary perspective. We found cells that were dividing first scattered throughout the retina, then, in later stages, proliferation was confined to the ciliary marginal zone. This pattern was confirmed by the expression of the proliferative marker PCNA. Both proliferation and apoptosis occurred in successive waves, and two apoptotic peaks were detected: one at premetamorphosis 1 and the second at prometamorphosis. PARP‐1, a known molecular marker of apoptosis, was used to confirm the data obtained by counting pyknotic nuclei. In summary, proliferative and apoptotic waves display an inverse time‐relationship through development, with apoptotic peaks coinciding with low proliferation phases. In a comparative perspective, amphibians follow a developmental pattern similar to other vertebrates, although with different timing. J. Exp. Zool. (Mol. Dev. Evol.) 326B:19–30, 2016. © 2015 Wiley Periodicals, Inc.
Synthesis and Characterization of New 1‐(4‐Methylpiperazin‐1‐yl)thioureas as Potential Antitubercular Agents
Authors: Hearn Michael J. , Wang Tracy , Cynamon Michael H.
Published: November 2015

Synthesis, characterization, and preliminary biological assessments of compounds with antitubercular activity.
Regioregular Polythiophene–Porphyrin Supramolecular Copolymers for Optoelectronic Applications
Authors: Chevrier Michèle , Kesters Jurgen , Blayo Camille , Richeter Sébastien , Van Der Lee Arie , Coulembier Olivier , Surin Mathieu , Mehdi Ahmad , Lazzaroni Roberto , Evans Rachel C. , Maes Wouter , Dubois Philippe , Clément Sébastien
Published: November 2015

Conjugated poly(3‐hexylthiophene) copolymer derivatives containing 10% appended porphyrin moieties are prepared using a supramolecular approach toward applications in organic electro­nics. The self‐assembled polythiophene–porphyrin copolymers are synthesized by coordination of the porphyrinato central zinc ions to the imidazole‐functionalized polythiophene side chains. Evidence for the self‐assembly process is provided by 1H NMR spectroscopy, single crystal X‐ray diffraction, and optical absorption studies on model compounds. The polythiophene–porphyrin copolymers show an extended absorption window in the region of 420–650 nm due to the contribution of the porphyrin. Photoluminescence studies indicate concentration‐dependent energy transfer from P3HT to the porphyrin. Preliminary photovoltaic studies are performed by combining the polythiophene–porphyrin copolymers with PC61BM in the photo­active layer of bulk heterojunction organic solar cells.

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A coupled two‐phase fluid flow and elastoplastic deformation model for unsaturated soils: theory, implementation, and application
Authors: Hu Ran , Chen Yi‐Feng , Liu Hui‐Hai , Zhou Chuang‐Bing
Published: November 2015

Although numerous numerical models have been proposed for simulating the coupled hydromechanical behaviors in unsaturated soils, few studies satisfactorily reproduced the soil–water–air three‐phase coupling processes. Particularly, the impacts of deformation dependence of water retention curve, bonding stress, and gas flow on the coupled processes were less examined within a coupled soil–water–air model. Based on our newly developed constitutive models (Hu et al., 2013, 2014, 2015) in which the soil–water–air couplings have been appropriately captured, this study develops a computer code named F2Mus3D to investigate the coupled processes with a focus on the above impacts. In the numerical implementation, the generalized‐α time integration scheme was adopted to solve the equations, and a return‐mapping implicit stress integration scheme was used to update the state variables. The numerical model was verified by two well‐designed laboratory tests and was applied for modeling the coupled elastoplastic deformation and two‐phase fluid flow processes in a homogenous soil slope induced by rainfall infiltration. The simulation results demonstrated that the numerical model well reproduces the initiation of a sheared zone at the toe of the slope and its propagation toward the crest as the rain infiltration proceeds, which manifests a typical mechanism for rainfall‐induced shallow landslides. The simulated plastic strain and deformation would be remarkably underestimated when the bonding stress and/or the deformation‐dependent nature of hydraulic properties are ignored in the coupled model. But on the contrary, the negligence of gas flow in the slope soil results in an overestimation of the rainfall‐induced deformation. Copyright © 2015 John Wiley & Sons, Ltd.
Editorial optimal control of solar energy systems
Authors: Camacho Eduardo F. , Berenguel Manuel
Published: November 2015

This special issue presents different applications of optimal control to solar energy systems. Papers focus on transitioning from theoretical to practical studies with emphasis on methodologies for the design, synthesis and application of optimal control to solar energy systems. Copyright © 2015 John Wiley & Sons, Ltd.
Loss of Mismatched HLA on the Leukemic Blasts of Patients With Relapsed Lymphoid Malignancies Following Bone Marrow Transplantation From Related Donors With HLA Class II Mismatches in the Graft Versus Host Direction
Authors: Hirabayashi Koichi , Kurata Takashi , Horiuchi Kazuki , Saito Shoji , Shigemura Tomonari , Tanaka Miyuki , Yanagisawa Ryu , Matsuda Kazuyuki , Sakashita Kazuo , Koike Kenichi , Nakazawa Yozo
Published: November 2015

Mechanisms of relapse of acute lymphoblastic leukemia (ALL) after human leukocyte antigen (HLA) class II mismatched hematopoietic stem cell transplantation (HSCT) remain unclear. We report two children with relapsed ALL after HSCT from related donors with HLA‐DRB1 and ‐DQB1 mismatches in the graft versus host direction. One lost HLA‐DRB1, DQB1, and DPB1 alleles, and the other lost one HLA haplotype of the leukemic blasts at relapse. HLA class II loss may be a triggering event for ALL relapse after partially HLA‐mismatched‐related HSCT. In addition, HLA typing of relapsed leukemic blasts could be vital in the selection of retransplant donors.
Case study of a low‐voltage distribution grid with high PV penetration in Germany and simulation analyses of cost‐effective measures
Authors: Carigiet Fabian , Niedrist Markus , Scheuermann Christian , Baumgartner Franz
Published: November 2015

The low‐voltage distribution grid in Dettighofen, Germany was analysed regarding load flows and the voltage behaviour because of decentralised photovoltaic (PV) power generation. High load flow fluctuations of 400 kW within 25 min were observed in the more critical western part of the grid. During the night, the average base and the peak load obtained from the medium voltage grid was 55.8 and 150 kW, respectively. On certain days, the transformer (400 kVA) fed with rated power into the medium‐voltage grid. The relative voltage rise on the transformer was between 2% and 3%. A critical situation was found at a distribution box with two long stubs and a total PV installation power of 99.3 kWp. The load flows caused a relative voltage rise of 4.5% on a day with clear sky, and there was a voltage peak slightly above 110% on a day with high fluctuating irradiance. In a second step, load flow simulations with NEPLAN were performed to analyse three different voltage reducing measures. The relative voltage rise could be reduced by 3% with an active power curtailment ratio of 70% together with reactive power control (cosφ of 0.95 and cosφ of 0.9 at p > 13.8kW). Peak shifting with battery storage leads to the same reduction if the power that exceeds 40% of the rated PV power is shifted. The average costs of limiting the active power to 70% are 1.45 ct/kWh compared with €3.11/kWh for peak shifting with commercial available lead‐acid batteries. This is due to the low number of storage cycles resulting in high costs. Copyright © 2015 John Wiley & Sons, Ltd.
Evacuation simulation of confined spaces in petrochemical facilities
Authors: Wang Zhen , Wilson Peg , Wang Qingsheng
Published: November 2015

With the growth of the petrochemical industry, confined space evacuation has been a major safety issue due to the potential fatalities and injuries caused by inadequate emergency response. In this work, two existing software, BuildingEXODUS and FDS+Evac, were used to simulate the required safe egress time (RSET) in different evacuation environments. Vertical and horizontal storage tanks were constructed using these two simulation software. Then, different parameters such as occupant load, with and without internal obstruction, and exit size were studied in different simulation scenarios. The simulation results from the software have shown good agreement with those from field experiments. It was found that the RSET of a vertical storage tank is nearly half of that of a horizontal storage tank. The work has demonstrated that the fire safety software could be used to simulate evacuations from confined spaces in petrochemical facilities. © 2015 American Institute of Chemical Engineers Process Saf Prog 35: 270–275, 2016
Involving user perspective in a software risk management process
Authors: Lindholm Christin
Published: November 2015

More and more user groups are using medical devices. Heart starters are, for example, available in public places and used by non‐professionals. Different mobile medical applications, designed to help people manage their own health, are now being added to the medical device spectra. Users handling medical devices make errors, but by involving users in the risk management process, it is possible to lower the risk of these errors. This paper presents an evaluation of the value of complementing a traditional risk management process with an emphasised user perspective. A medical device software risk management framework is being designed, and the risk management process should be regarded as the first part of the framework. The main goal of the evaluated risk management process is to integrate users and user perspective into the risk management process. The results indicate that the use of use cases as input at risk meetings makes the discussions more focused, saving effort and time. When users attend the risk meetings, user perspective and domain knowledge are brought into the process, affecting risk identification and risk assessment. The results also show that the use of usability testing gives valuable input to the risk management process. Copyright © 2015 John Wiley & Sons, Ltd.
Study of absorption parameters around the K edge for selected compounds of Gd
Authors: Akman F. , Durak R. , Kacal M. R. , Bezgin F.
Published: November 2015

The K shell absorption jump ratios, jump factors, effective atomic numbers, and electron densities were derived from the measured total mass attenuation coefficient using an energy dispersive X‐ray fluorescence spectrometer for Gd2O3, Gd2(CO3)3H2O, Gd2(C2O4)3H2O, and Gd2(SO4)3 compounds. The total mass attenuation coefficients were measured in the X‐ray energy range from 39.52 to 57.14 keV in a transmission geometry utilizing the Kα2, Kα1, Kβ1, and Kβ2 X‐rays from different secondary source targets excited by the 59.54‐keV photons from an Am‐241 annular source and detected by a Si(Li) detector with a resolution of 160 eV at 5.9 keV. The energy gap, ionization energy, electron affinity, and global electrophilicity parameters of oxide, sulfate, oxalate, and carbonate ions were calculated using density functional theory (B3LYP). The experimental results are discussed based on these parameters. Copyright © 2015 John Wiley & Sons, Ltd.
Combined PIXE and X‐ray diffraction analysis of accretionary lapilli from the Cretaceous/Paleogene boundary El Guayal Section, Tabasco, Mexico
Authors: Bucio L. , Ruvalcaba‐Sil J. L. , Thions C. , Urrutia‐Fucugauchi J. , Orozco E.
Published: November 2015

By employing the techniques, X‐ray powder diffraction (XRPD) and particle‐induced X‐ray emission (PIXE), it could be obtained in a simply way an overall vision of the structure and chemical composition of a spheroid (lapillus) collected in the K/Pg deposit located at the place called El Guayal in Tabasco, Mexico. The XRPD analysis indicates the presence of an amorphous and four crystalline phases (quartz, calcite, ankerite, and montmorillonite) in the spheroid. None sulfur crystalline phases were detected. PIXE results show the presence of different atoms in a weight percentage that follows the sequence: Si > Al > Ca > Fe > Sr > Cu > Ti > Mn > Y > Rb > Zn > Pb. None of platinum group elements were detected.

PIXE analysis by of the lapillus shows the presence of the most abundant atoms in the Earth's crust, but in this case, the relative abundance Fe‐Ca is inverted, and the Sr/Rb proportion is considerably higher than that observed in the crust. Additionally, nor sulfur or any of the platinum group elements was detected in the lapillus. Except for the case of trace elements detected, in general, no characteristic pattern is observed in the distribution of the most abundant elements. Copyright © 2015 John Wiley & Sons, Ltd.
Long‐Term Surveillance of Treated Hyperparathyroidism for Multiple Endocrine Neoplasia Type 1: Recurrence or Hypoparathyroidism?
Authors: Fyrsten Ellen , Norlén Olov , Hessman Ola , Stålberg Peter , Hellman Per
Published: November 2015

Background

Primary hyperparathyroidism (HPT) in multiple endocrine neoplasia type 1 (MEN1) is surgically treated with either a subtotal parathyroidectomy removing 3 or 3,5 glands (SPX), less than 3 glands (LSPX), or a total parathyroidectomy with autotransplantation (TPX). Previous studies with shorter follow‐up have shown that LSPX and SPX are associated with recurrent HPT, and TPX with hypocalcemia and substitution therapy. We examined the situation after long‐term follow‐up (median 20,6 years).

Methods

Sixty‐nine patients with MEN1 HPT underwent 110 operations, the first operation being 31 LSPX, 30 SPX, and 8 TPX. Thirty patients underwent reoperative surgery in median 120 months later, as completion to TPX (n = 12), completion of LSPX to SPX (n = 9), extirpation of single glands (n = 3) still resulting in LSPX, and resection of forearm grafts (n = 3). Nine patients underwent a second, and 2 a third reoperation. In 24 patients genetic testing confirmed MEN1, and in the remaining heredity and phenotype led to the diagnosis.

Results

TPX had higher risk for hypoparathyroidism necessitating substitution therapy, at latest follow‐up 50 %, compared to SPX (16 % after 3–6 months; none at latest follow‐up). Recurrent HPT was common after LSPX, leading to 24 reoperations in 17 patients. No need for substitution therapy after SPX indicated forthcoming recurrent disease. Not having hypocalcemia in the postoperative period and less radical surgery than TPX were significantly associated to risk for recurrence. Further, mutation in exon 3 in the MEN1 gene may eventually be linked to risk of recurrence.

Conclusion

LSPX is highly associated with recurrence and TPX with continuous hypoparathyroidism, also after long‐term follow‐up. SPX should be the chosen method in the majority of patients with MEN1 HPT.
A generalized asymmetric exclusion process with $$U_q(\mathfrak {sl}_2)$$ stochastic duality
Authors: Carinci Gioia , Giardinà Cristian , Redig Frank , Sasamoto Tomohiro
Published: November 2015

We study a new process, which we call ASEP(q, j), where particles move asymmetrically on a one-dimensional integer lattice with a bias determined by $$q\in (0,1)$$

q
∈
(
0
,
1
)

and where at most $$2j\in \mathbb {N}$$

2
j
∈
N

particles per site are allowed. The process is constructed from a $$(2j+1)$$

(
2
j
+
1
)

-dimensional representation of a quantum Hamiltonian with $$U_q(\mathfrak {sl}_2)$$

U
q

(

sl
2

)

invariance by applying a suitable ground-state transformation. After showing basic properties of the process ASEP(q, j), we prove self-duality with several self-duality functions constructed from the symmetries of the quantum Hamiltonian. By making use of the self-duality property we compute the first q-exponential moment of the current for step initial conditions (both a shock or a rarefaction fan) as well as when the process is started from a homogeneous product measure.
Soil and Rhizosphere Associated Fungi in Gray Mangroves (Avicennia Marina) from the Red Sea — A Metagenomic Approach
Authors: Simões Marta Filipa , Antunes André , Ottoni Cristiane A. , Amini Mohammad Shoaib , Alam Intikhab , Alzubaidy Hanin , Mokhtar Noor-Azlin , Archer John A.C. , Bajic Vladimir B.
Published: November 2015

Covering a quarter of the world’s tropical coastlines and being one of the most threatened ecosystems, mangroves are among the major sources of terrestrial organic matter to oceans and harbor a wide microbial diversity. In order to protect, restore, and better understand these ecosystems, researchers have extensively studied their microbiology, yet few surveys have focused on their fungal communities. Our lack of knowledge is even more pronounced for specific fungal populations, such as the ones associated with the rhizosphere. Likewise, the Red Sea gray mangroves (Avicennia marina) remain poorly characterized, and understanding of their fungal communities still relies on cultivation-dependent methods. In this study, we analyzed metagenomic datasets from gray mangrove rhizosphere and bulk soil samples collected in the Red Sea coast, to obtain a snapshot of their fungal communities. Our data indicated that Ascomycota was the dominant phylum (76%–85%), while Basidiomycota was less abundant (14%–24%), yet present in higher numbers than usually reported for such environments. Fungal communities were more stable within the rhizosphere than within the bulk soil, both at class and genus level. This finding is consistent with the intrinsic patchiness in soil sediments and with the selection of specific microbial communities by plant roots. Our study indicates the presence of several species on this mycobiome that were not previously reported as mangrove-associated. In particular, we detected representatives of several commercially-used fungi, e.g., producers of secreted cellulases and anaerobic producers of cellulosomes. These results represent additional insights into the fungal community of the gray mangroves of the Red Sea, and show that they are significantly richer than previously reported.
ISDN2014_0015: REMOVED: In‐silico modelling of SERAC1: Protein involved in a developmental neural disorder MEGDEL syndrome characterized by 3‐methyl glutaconic aciduria type IV with sensory‐neural deafness, encephalopathy and Leigh‐like syndrome
Authors: Debnath Surajit , Addya Soma
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0043: REMOVED: Neuroplastin 65 knock out improves the cognitive function and inhibits LTP of mice
Authors: Wu Shuang , Zhang Haibo , Huang Liang , Liu XiaoQing , Yuan Qiong‐lan
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0070: REMOVED: In vivo examination of the relationship between estrogen receptors and microtubule dynamic: A new hypothesis about neuronal degeneration
Authors: Karamese Murat , Aksak Karamese Selina , Karakus Emre , Gundogdu Ozge B. , Unal Bunyami
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0077: REMOVED: Novel endosomal mechanisms in human axonal growth mediated by Christianson syndrome protein NHE6
Authors: Morrow Eric M. , Lizarraga Sofia B. , Ouyang Qing
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0099: REMOVED: Reversal of immobilization stress‐induced anorexia and endogenous leptin levels by Rauwolfia serpentina in rats: Relationship with adaptation to stress
Authors: Shireen Erum , Bint‐e‐Ali Wafa , Shafaq Sania , Majeed Azka , Fatima Rija , Masroor Maria , Haleem Darakshan J.
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0126: REMOVED: TBI enhances seizure susceptibility via affecting BDNF‐TrkB signaling pathway
Authors: Garjan Tahereh Ghadiri , Sharifzadeh Mohammad , khodagholi Fariba , Zarindast Mohammadreza , Gorji Ali
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0133: REMOVED: Brain specific xanthine oxidase in the presence of pyridoxine might serve as a triggering enzyme for the proliferation of the cells
Authors: Aganyants H.A. , Danielyan K.E.
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0180: REMOVED: Wee1 interacts with beta4GalT‐VII in neuronal development
Authors: Xiao Jianying
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0300: REMOVED: White matter connectivity in dyslexia
Authors: García‐Pentón L. , Pérez A. , Lerma G. , Paz‐Alonso P.M. , Iturria‐Medina Y. , Carreiras M.
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0395: REMOVED: Self‐assembling MMP‐2 cleavable hydrogel drug delivery systems for neural tissue injury
Authors: Koss K. , Churchward M. , Todd K. , Unsworth L.D.
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
The genotype distribution of hepatitis C in southeastern Taiwan: Clinical characteristics, racial difference, and therapeutic response
Authors: Cheng Chun‐Han , Chen Huan‐Lin , Lin I‐Tsung , Wu Chia‐Hsien , Lee Yuan‐Kai , Wong Ming‐Wun , Bair Ming‐Jong
Published: November 2015

The genotypes of hepatitis C virus (HCV) are associated with the therapeutic response. The racial diversity of Taitung, Taiwan is heterogeneous and a distinguishing feature; how such racial differences influence the genotype distribution and treatment outcome has not been well studied. The objective of this study is to elucidate the HCV genotype distribution in southeastern Taiwan and to analyze the racial differences influencing genotypes and clinical implications. In this retrospective cohort study, we included 343 patients who had been treated with peginterferon‐alpha plus ribavirin. The predominant HCV genotype in the southeastern area was type 1 (43.7%), followed by type 2 (37.0%). The proportion of patients mixed with genotype 1 was lower in indigenous vis‐à‐vis nonindigenous groups (46.1% and 60.2%, p = 0.02). The prevalence of genotype 6 (5.2%) seems higher than in the general population of Taiwan and showed no difference between indigenous and nonindigenous people. The sustained virological response rate was higher in patients without genotype 1, low baseline HCV RNA (≤ 400,000 IU/mL), and in patients who achieved rapid virological response. Racial differences did not influence the therapeutic response. In this retrospective study, the proportion of HCV genotype 6 appeared slightly higher in southeastern areas than in the general population in Taiwan. The prevalence of genotype 1 in indigenous people was statistically lower than in nonindigenous people. Sustained virological response rate did not show any significant difference between indigenous and nonindigenous people in the current study.
Delayed Sciatic Nerve Injury Resulting From Myositis Ossificans Traumatica
Authors: Guan Zhe , Wilson Thomas J. , Jacobson Jon A. , Hollon Todd C. , Yang Lynda J.‐S.
Published: November 2015

A motorcyclist sustained multiple‐system trauma, including a left buttock hematoma requiring decompression and evacuation. Presentation for severe hip pain and lower extremity weakness was delayed. Imaging revealed myositis ossificans traumatica compressing the sciatic nerve in the buttock. The patient underwent sciatic nerve decompression with resection of heterotopic calcification, resulting in improvement in pain and left lower extremity function. This case illustrates the contrast in differential diagnosis of peripheral nerve injury immediately posttrauma and that occurring in a slow, delayed fashion posttrauma. Myositis ossificans may be an underrecognized complication of trauma but should be considered in cases of delayed peripheral nerve injury after trauma.
Thoracic Radiculopathy Resulting From Retrograde Neuronal Degeneration
Authors: Kim Dae Hyun , Choi Jung Hwa , Park Yoon Ghil
Published: November 2015

We report a case of thoracic radiculopathy caused by retrograde degeneration from an intercostal nerve mass. A 74‐year‐old woman presented with thoracic radicular pain in the T4 dermatome. Needle electromyography revealed abnormal spontaneous activity in the left paraspinal muscle. Magnetic resonance imaging of the thoracic spine showed no signs of a herniated thoracic disk or root compression but revealed a mass along the intercostal space. The pathologic findings included perineural infiltration. A mass located along the intercostal space approximately 1.8 cm from the dorsal root ganglion may cause thoracic radiculopathy via retrograde degeneration.