bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH SIKAP, KESADARAN WAJIB PAJAK, DAN PENGETAHUAN PERPAJAKAN PADA KEPATUHAN MEMBAYAR PAJAK BUMI DAN BANGUNAN (Studi Kasus Di Desa Cening Kec.Singorojo )
Authors: Iin Indarti
Published: September 2024

Penelitian ini bertujuan untuk menganalisis pengaruh sikap (X1), kesadaran wajib pajak (X2), dan pengetahuan perpajakan (X3) terhadap kepatuhan membayar Pajak Bumi dan Bangunan (Y) yang dilakukan di Desa Cening Kecamatan Singorojo. Populasi dalam penelitian ini adalah wajib Pajak Bumi dan Bangunan yang membayar pajak di kantor Kelurahan Desa Cening, dengan sampel 94 pembayar pajak. Teknik pengambilan sampel yang digunakan adalah probability sampling. Metode statistik yang digunakan adalah analisis regresi linear berganda,
sebelumnya dilakukan uji asumsi klasik yaitu uji normalitas, uji multikolinieritas, uji heteroskedastisitas, dan uji reliabelitas dan uji validitas. Hasil pengujian menunjukkan bahwa sikap (X1) tidak berpengaruh terhadap kepatuhan membayar pajak bumi dan bangunan, kesadaran wajib pajak (X2) berpengaruh terhadap kepatuhan membayar pajak bumi dan bangunan, dan pengetahuan perpajakan (X3)tidak berpengaruh terhadap kepatuhan membayar pajak bumi dan bangunan, dan secara bersama-sama sikap (X1), kesadaran wajib pajak (X2), pengetahuan perpajakan (X3) berpengaruh terhadap kepatuhan membayar Pajak Bumi dan Bangunan. Hasil uji koefiisien determinasi sebesar 6,6% yang berpengaruh sedangkan sisanya 93,4% dipengaruhi oleh variabel lain diluar penelitian (SPPT, pelayanan fiskus, sistem perpajakan, dsb)
PENGARUH KUALITAS LAYANAN YANG DI RASAKAN PELANGGAN TERHADAP LOYALITAS PELANGGAN: PERAN MEDIASI KEPUASAN PELANGGAN PADA KANTOR POS UNGARAN
Authors: Yudho Purnomo  , Mohamad Sodikin  , Fitra Bhagavadgita Sandy Asmara N.S
Published: September 2024

Di era globalisasi ini, perkembangan usaha di bidang penyediaan jasa menunjukkan tren yang sangat positif. Hal ini membuat persaingan antar perusahaan semakin ketat, oleh karena itu perlunya menyusun strategi untuk mengatasi persaingan tersebut. Saat ini sudah banyak sekali perusahaan di Indonesia yang bergerak di bidang jasa distribusi kargo, baik itu perusahaan milik negara maupun swasta. Kantor Pos Ungaran merupakan salah satu cabang dari PT. Indonesia Post terletak di Provinsi Jawa Tengah. Permasalahan utama yang dihadapi Perusahaan Kantor Pos Ungaran adalah persaingan bisnis di industri petualangan selalu semakin ketat, setiap perusahaan berusaha menarik konsumen sebanyak-banyaknya. Mengingat pentingnya masalah kepuasan dan loyalitas pelanggan, maka penelitian ini fokus pada Kantor Pos Ungaran, salah satu perusahaan yang bergerak di industri jasa pengiriman. Kantor Pos Ungaran kini memiliki lebih dari satu pelanggan tetap.
PENGARUH PENERAPAN AUTO GATE SYSTEM, KINERJA BONGKAR MUAT DAN LAPANGAN PENUMPUKAN TERHADAP EFEKTIVITAS PENGIRIMAN BARANG DI TERMINALPETI KEMAS TANJUNG EMAS SEMARANG
Authors: M. Shohibul Jamil  , Dirgo Wahyono  , Rifo Desga Kusuma
Published: September 2024

Indonesia merupakan negara kepulauan yang memiliki struktur pulau-pulau yang tersebar secara luas. Tingginya tingkat ekspor maupun impor yang terjadi maka dibutuhkan wadah untuk menangani hal tersebut. Terminal Peti Kemas Semarang merupakan perusahaan peti kemas yang menangani pelayanan gate dan pelayanan jasa bongkar muat untuk pengiriman suatu barang. Tujuan Penelitian iniadalah untuk mengetahui adakah pengaruh penerapan autogate, kinerja bongkar muat, dan lapangan penumpukan terhadap Efektivitas pengiriman barang. Salah satu metode yang dapat digunakan dalam menganalisis data adalah metode kuantitatif. Pengumpulan data dilakukan melalui metode observasi, studi pustaka, dokumentasi dan kuesioner. Teknik analisis yang digunakan adalah regresi linier berganda dengan bantuan program SPSS V.26. Berdasarkan hasil penelitian dan analisis berganda dihasilkan persamaan:Y = -692 + 0,480X1+ 0,542X2 + 0,018X3 Berdasarkan hasil pengisian kuesioner dan hasil persamaan regresi linier berganda menunjukkan bahwa variabel penerapan auto gate system (X1) mempunyai (thitung 10.272 > ttabel 1,991), variabel kinerja bongkar muat (X2) mempunyai (thitung 11.296 > ttabel 1,991), dan variabel lapangan penumpukan (X3) mempunyai (thitung 632 < ttabel 1,991). Sedangkan nilai adjusted R2 = 0.909. Hal ini berarti 90.9% variasi variabel terikat (Y) yaitu efektivitas pengiriman barang dapat dijelaskan atau disebabkan oleh variabel bebas yaitu , penerapan auto gate system (X1), kinerja bongkar muat (X2,), lapangan penumpukan (X3),. Sedangkan sisanya 100% - 90.9%%=9.1%, dijelaskan oleh sebab-sebab yang lain di luar variabel yang diteliti. Dengan demikian hasilpenelitian menunjukkan, penerapan auto gate system, kinerja bongkar muat, lapangan penumpukan berpengaruh positif dan signifikan terhadap efektivitaspengiriman barang di TPK Semarang.
PENGARUH DISIPLIN, KEPEMIMPINAN DAN KEPUASAN KERJA TERHADAP TURNOVER INTENTION DIVISI MINERAL DAN BATUBARA PT. SURVEYOR INDONESIA CABANG SURABAYA
Authors: Yudho Purnomo  , Sugiarto  , Arman Nurfaizi
Published: September 2024

Turnover intention adalah keinginan seseorang untuk meninggalkan organisasi tempatnya bekerja sekarang. Banyak faktor dapat mempengaruhi turnover intention yaitu disiplin kerja, kepemimpinan dan kepuasan kerja. Obyek penelitian ini PT. Surveyor Indonesia Cabang Surabaya dimana pada tahun 2023, terdapat 7 karyawan PT. Surveyor Indonesia Cabang Surabaya yang mengundurkan diri yang disebabkan karena adanya ketidaknyamanan bekerja di perusahaan. Oleh karena itu, tujuan penelitian ini adalah menganalisis pengaruh disiplin, kepemimpinan dan kepuasan kerja baik secara scara parsial maupun simultan terhadap turnover intention karyawan
Populasi dan sampel riset ini yaitu karyawan divisi mineral dan batubara PT. Surveyor Indonesia Cabang Surabaya, Jl. Ngagel Jaya No. 53 A, Pucang Sewu, Kecamatan Gubeng, Surabaya, Jawa Timur yang berjumlah 45 orang. Teknik sampel dalam penelitian ini dilakukan dengan teknik non acak jenis sensus. Jenis datanya primer dan sekunder. Metodepengumpulan datanya angket atau kuesioner. Metode analisis yang digunakan adalah regresi berganda dengan sebelumnya dilakukan pengujian instrumen (validitas dan reliabilitas).
Hasil penelitian menunjukkan bahwa : Disiplin berpengaruh signifikan terhadap turnover intention. Kepemimpinan berpengaruh signifikan terhadap turnover intention. Kepuasan kerja berpengaruh signifikan terhadap turnover intention. Disiplin, kepemimpinan, dan kepuasan kerja berpengaruh signifikan terhadap turnover intention secara simultan
PROFITABILITAS BANK UMUM SYARIAH DI INDONESIA: PEMBIAYAAN MURABAHAH DAN IJARAH
Authors: Rafika Aulia Fauzi  , Guntur Kusuma Wardana
Published: September 2024

Penelitian ini bertujuan untuk menganalisis pengaruh pembiayaan murabahah dan ijarah terhadap profitabilitas Bank Umum Syariah di Indonesia baik secara parsial maupun simultan. Data yang digunakan berupa laporan tahunan masing-masing Bank Umum Syariah di Indonesia periode 2017 hingga 2022. Dengan menggunakan teknik purposive sampling, terdapat 5 Bank Umum Syariah yang dijadikan sampel penelitian. Adapun metode analisis yang digunakan yaitu metode regresi linier berganda dengan menggunakan data panel. Hasil penelitian menunjukkan bahwa pembiayaan murabahah berpengaruh secara parsial terhadap profitabilitas Bank Syariah di Indonesia. Untuk pembiayaan ijarah tidak berpengaruh secara parsial terhadap profitabilitas Bank Syariah di Indonesia. Adapun secara simultan, pembiayaan murabahah dan ijarah berpengaruh terhadap profitabilitas Bank Syariah di Indonesia.
ANALISIS TINGKAT KESEHATAN PADA ASPEK JATI DIRI KOPERASI PADA KOPERASI SYARIAH HIDAYATUSSUNAH MASJID JAMI MUNGSOLKANAS CHIAMPELAS-BANDUNG
Authors: Nanang Sobarna
Published: September 2024

ABSTRAK
Penelitian ini bertujuan untuk mengetahui tingkat kesehatan Koperasi Syariah Hidayatussunnah Masjid Jami Munsolkanas Chimapelas-Bandung. Untuk menganalisis tingkat kesehatan pada tahun 2021 yang mengacu pada peraturan deputi bidang pengawasan kementerian koperasi dan UKM No.07/Per/Dep.6/IV/2016 yang meliputi aspek jati diri dengan perhitunganya menggunakan dua rasio yaitu rasio partisipasi bruto dan rasio partisipasi ekonomi anggota. Yang dimana menghasilkan perhitungan dari hasil penelitian yang telah dilakukan pada koperasi  Syariah Hidayatussunnah Masjid Jami Munsolkanas Chimapelas-Bandung. Bahwa koperasi ini termasuk kedalam kategori koperasi yang memiliki kriteria yang rendah dalam pelayanan anggotanya serta memberikan cukup manfaat terhadap anggotanya.
Kata kunci : Tingkat Kesehatan, Aspek Penilaian, kriteria penilaian
DAMPAK COVID 19 TERHADAP PEREKONOMIAN DI DESA SEMAMBUNG KECAMATAN JATIBANTENG KABUPATEN SITUBONDO
Authors: M. Ilham Zainullah
Published: September 2024

Perekonomian di tahun 2020 yang mana kita ketahui dengan keadaan COVID 19 sekarang banyak dari mereka yang keadaan ekonominya anjlok sehingga mereka kekurangan SDM seperti sayuran,pasar di tutup dan banyak toko yang di suruh tutup dan mengakibat kan mereka kekurang SDM dan juga pendapatan mereka itu yang mereka rasakan di kalangan pedesaan atau lebih tepatnya di desa semambung,jatibanteng situbondo Kerugian yang paling mudah dihitung adalah kerugian agregat secara nasional. Namun karena bersifat makro, maka perhitungan ini hanya digunakan oleh pelaku ekonomi skala besar. Tujuan penelitian ini untuk mengetahui dampak covid 19 terhadap perekonomian di Desa Semambung Kecamatan Jatibanteng Kabupaten Situbondo.
KEPUASAN NASABAH SEBAGAI VARIABEL INTERVENING PADA PENGARUH ISLAMIC MARKATING MIX 7P TERHADAP LOYALITAS NASABAH KSPPS. BMT NU JAWA TIMUR CABANG BONDOWOSO
Authors: Habibatur Rahma Siti
Published: September 2024

Pada saat ini, suatu perusahaan dituntut untuk melakukan manajemen pemasaran yang terarah guna menguasai pangsa pasar. Oleh karenanya, perusahaan perlu melakukan strategi pemasaran guna memberikan rangsangan kepada konsumen untuk mempengaruhi keputusan konsumen dalam memilih suatu produk. Penelitian ini bertujuan untuk menganalisis dan menguji secara empiris variabel-variabel dalam penelitian yang telah dirumuskan dalam rumusan masalah, yaitu apakah terdapat pengaruh antara Pragmatism, Pertinence, Palliation, Peer-Support, Pedagogy, Persistence dan Patience terhadap Loyalitas Nasabah (Y) dengan Kepuasan Pelanggan (Z) sebagai variabel Intervening. Pengambilan sampel dalam penelitian ini menggunakan metode non-probability sampling berupa accidental sampling sejumlah 220 nasabah KSPPS BMT NU JATIM Cabang Bondowoso. Alat pengumpulan data menggunakan kuisioner yang diukur dengan skala likert. Kuisioner diuji menggunakan uji validitas dan reliabilitas. Data dianalisis menggunakan analisis analisis jalur (path analysis). Hasil analisis menunjukkan bahwa Pragmatism, Pertinence, Palliation, Peer-Support, Pedagogy, Persistence dan Patience terhadap Kepuasan Nasabah. Serta Pragmatism, Pertinence, Palliation, Peer-Support, Pedagogy, Persistence dan Patience terhadap Loyalitas Nasabah. Dan kepuasan nasabah berpengaruh positif dan signifikan terhadap loyalitas nasabah.
PENDAMPINGAN PASTORAL KONSELING BAGI REMAJA KORBAN PERCERAIAN
Authors: Taarega Viena Bella , Tadung Frieska Putrima
Published: September 2024

Divorce creates a dangerous situation in the life of a teenager. Nowadays, divorce is becoming more and more common. This then affects the self-acceptance of adolescents. Many churches today only care about adults who are considered to be actors in a divorce. The church has not provided pastoral assistance to youth as victims of divorce. Divorce is a wound that can be traumatic for teenagers. Adolescence is a period of transition to early adulthood, where the development period is the most difficult to pass. Adolescence is a time of forming a person's identity, the crisis experienced when his parents divorced will have an impact on his life in the future of adolescence. Pastoral assistance aims to assist, guide, and assist adolescents who are victims of divorce to obtain healing and recovery. This study uses a qualitative research method with a case study approach.
Separation of active chiral particles with different diffusion coefficients
Authors: Li Chen-Pu , Wu Wei-Xia , Zhang Li-Gang , Hu Jin-Jiang , Xie Ge-Ying , Zheng Zhi-Gang ,   School of Science, Hebei University of Architecture, Zhangjiakou 075000, China,   Science Education Department, Beijing Institute of Graphic Communication, Beijing 102600, China,   Institute of Systems Science, Huaqiao University, Xiamen 361021, China,   College of Information Science and Engineering, Huaqiao University, Xiamen 361021, China
Published: September 2024

In recent years, the study of active particles has become one of the important topics concerned by researchers in many fields, among which the phase separation of active chiral particles has important theoretical and practical significance. In this paper, the phase separation of binary mixed systems composed of active chiral particles with different diffusion coefficients is studied by Langevin dynamics. A smaller relative diffusion coefficient is conducive to the formation of large clusters and the separation of “cold” particles, while a larger relative diffusion coefficient will weaken the separation effect. Due to the influence of particle characteristics (self-driven velocity, self-rotational angular velocity) and relative diffusion coefficient on the collision between particles, if one wants the “cold” and “hot” particles to reach phase separation, increasing (or reducing) the self-driven velocity and self-rotational angular velocity cannot be synchronous, and the relative rate of change of self-driven velocity is smaller than that of the self-rotational angular velocity. By analyzing the changes of the effective diffusion coefficient of “cold” particles, the phenomenon of phase separation in the system can be better explained. A smaller effective diffusion coefficient means that the “cold” particles will aggregate into larger clusters, and the system may exhibit phase separation. However, when the effective diffusion coefficient is larger, the diffusion of “cold” particles is stronger and the “cold” particles will not form large clusters, which means that the system cannot aggregate into phase separation. In addition, with the filling rate of particle increasing, the proportion curve of the number of cold particles in maximum cold particle cluster undergoes a non-monotonic change, specifically, it first increases and then decreases. Each curve has an optimal filling rate but its width is different .With the increase of the relative diffusion coefficient and self-driven velocity, the width of the optimal filling rate of the proportion curve will become narrower and shift toward the right.
Three-dimensional fluid simulation of a planar coil inductively coupled argon plasma source for semiconductor processes
Authors: Zhao Ming-Liang , Xing Si-Yu , Tang Wen , Zhang Yu-Ru , Gao Fei , Wang You-Nian ,   Key Laboratory of Materials Modification by Laser, Ion, and Electron Beams (Ministry of Education), School of Physics, Dalian University of Technology, Dalian 116024, China
Published: September 2024

In this paper, the effect of the coil structure, as well as the gas pressure, on the spatial distribution of an inductively coupled argon plasma is numerically investigated based on our developed three-dimensional fluid model. The model is based on a modified ambipolar diffusion model, in which the electron density is solved under the quasi-neutral condition, the ion density and neutral particle density are obtained by solving continuity equations, and the ion flux is achieved by solving the full momentum balance equation. In addition, the inductive electric field is governed by the Maxwell equations, which are solved in the frequency domain. The results show that the electron density is nonuniform along the azimuthal direction due to the asymmetry of the coil structure, and the uniformity becomes better as gas pressure decreases. Besides, the plasma azimuthal uniformity can also be improved by reducing the opening of the coil. As the coil radius increases, the plasma density decreases, while the radial uniformity of the plasma improves, and the azimuthal uniformity deteriorates. In addition, the influence of the current amplitude ratio between the inner coil and outer coil on the plasma uniformity in dual-coil discharge is also investigated. It is found that the plasma radial uniformity becomes better by reducing the inter-to-outer coil current amplitude ratio. The results obtained in this work demonstrate that the plasma uniformity can be improved by optimizing the coil structure and adjusting the discharge parameters, which is of significant importance in etching and deposition processes.
Dynamics of acoustically-induced droplet instability
Authors: Liu He , Yang Ya-Jing , Tang Yu-Ning , Wei Yan-Ju ,   School of Energy and Power Engineering, Xi’an Jiaotong University, Xi’an 710049, China,   State Key Laboratory of Mechanical Strength and Vibration, School of Aerospace, Xi’an Jiaotong University, Xi’an 710049, China
Published: September 2024

The advancement of the theory of droplet stability in the acoustic field is of significant value in improving ultrasonic atomization and ultrasonic levitation technology. In this work, in order to reveal the detailed mechanism of acoustic droplet instability and give the instability criterion for easy application, the dynamics of droplet instability in standing wave acoustic field (19.8 kHz) is studied by combining practical experiment, theoretical derivation and numerical calculation. The acoustic instability of the droplet occurring near the wave nodes is mainly manifested in two typical modes: disk instability and edge-sharpening instability. The appearance of these two instability modes depends on the relative magnitude of the standing wave field strength. Specifically, with the gradual enhancement of the intensity of the standing wave field, the instability mode of the droplet will gradually change from disc instability to edge-sharpened instability.The droplets show obvious self-accelerating expansion in the equatorial plane in the instability process. The positive feedback between the droplet aspect ratio and the negative pressure of acoustic radiation at the equator of the droplet is the reason for the above self-accelerating behavior. The theoretical results obtained through deduction indicate that the amplitude of the negative acoustic radiation pressure at the droplet equator is proportional to the square of the droplet aspect ratio. The surface tension of the droplet is the main factor hindering its deformation, while the acoustic radiation suction at the equator is the main factor driving the deformation of the droplet. Based on this, the force equilibrium equation of the droplet interface is established, and the dimensionless criterion of acoustic droplet instability, i.e. the acoustic Weber number Wea, is derived. When Wea≤1, the droplet interface stays in equilibrium, and when Wea >1, the equatorial acoustic suction is larger than the surface tension, and the droplet instability occurs, and the average error between the experimental results and the theoretical results is only 9%.
Research advances in antimatter
Authors: Ma Yu-Gang ,   Key Laboratory of Nuclear Physics and Ion-beam Application (MOE), Institute of Modern Physics, Fudan University, Shanghai 200433, China,   Shanghai Research Center for Theoretical Nuclear Physics, NSFC and Fudan University, Shanghai 200438, China
Published: September 2024

The asymmetric origin of matter and antimatter in the universe is an important unsolved mystery in science today. In this paper, we briefly review the history of antimatter research and the recent international hotspots of related research. This paper focuses on the advances in antimatter research made in recent years at the large-scale international RHIC-STAR experiment at the Relativistic Heavy Ion Collider, including the discovery of the first antimatter hypernucleus (anti-hypertriton), antimatter helium 4 and antihyperhydrogen 4, the first measurements of antiproton interactions, and the precise measurements of the mass and binding energy of the hypertriton and anti-hypertriton. The antimatter hypertriton nucleus, composed of an antiproton, an antineutron, and an anti-Λ hyperon, is the first anti-hypernucleu to be discovered, extending the three-dimensional nuclide map from the anti-strange quark degree of freedom. Antimatter Helium 4 is the heaviest stable antimatter nucleus yet discovered. Anti-hyperhydrogen 4, just discovered in 2024, is composed of an antiproton, two antineutrons, and an anti-Λ hyperon, and is the heaviest antimatter hypernucleus to date. Equivalence to the proton-proton interaction was established by measurements of the antiproton-antiproton interaction. At the same time, precise measurements of the mass of hypertriton and anti-hypertriton nuclei confirmed the equivalence of matter and antimatter. And these also fully demonstrate that the CPT symmetry is also valid for antimatter nuclei. Measurements of the binding energy of the hypertriton nucleus indicate that the interaction between Λ and the nucleus of the hypertriton (the deuterium nucleus) is strong, which differs from the earlier common belief that the hypertriton nucleus is a weakly bound system. Furthermore, we discuss different physical mechanisms for the production of (anti) light nuclei, mainly including thermal, coalescence and relativistic kinetic models. Finally, we also present recent results from antihydrogen atom experiments at CERN, antimatter space probes, etc., and discuss the implications of these advances for understanding the structure of matter. Overall, the existing studies of antimatter nuclei and atoms have not yet provided clear evidence for the asymmetric origin of matter and antimatter in the universe, which can help further improve the accuracy of various measurements in antimatter research. Of course, other efforts in this direction in nuclear and particle physics are well expected.
Robust variability of grid cell properties within individual grid modules enhances encoding of local space
Authors: Redman William T , Acosta-Mendoza Santiago , Wei Xue-Xin , Goard Michael J
Published: September 2024

Although grid cells are one of the most well studied functional classes of neurons in the mammalian brain, the assumption that there is a single grid orientation and spacing per grid module has not been carefully tested. We investigate and analyze a recent large-scale recording of medial entorhinal cortex to characterize the presence and degree of heterogeneity of grid properties within individual modules. We find evidence for small, but robust, variability and hypothesize that this property of the grid code could enhance the ability of encoding local spatial information. Performing analysis on synthetic populations of grid cells, where we have complete control over the amount heterogeneity in grid properties, we demonstrate that variability, of a similar magnitude to the analyzed data, leads to significantly decreased decoding error, even when restricted to activity from a single module. Our results highlight how the heterogeneity of the neural response properties may benefit coding and opens new directions for theoretical and experimental analysis of grid cells.
Lock out SIRT4
Authors: Zhao Kaiqiang , Zhou Zhongjun
Published: September 2024

The accumulation of SIRT4 in the nuclei of kidney cells drives kidney fibrosis, so blocking the movement of this protein could be a potential therapeutic strategy against fibrosis.
Peptidoglycan-tethered and free forms of the Braun lipoprotein are in dynamic equilibrium in Escherichia coli
Authors: Liang Yucheng , Hugonnet Jean-Emmanuel , Rusconi Filippo , Arthur Michel
Published: September 2024

Peptidoglycan (PG) is a giant macromolecule that completely surrounds bacterial cells and prevents lysis in hypo-osmotic environments. This net-like macromolecule is made of glycan strands linked to each other by two types of transpeptidases that form either 4→3 (PBPs) or 3→3 (LDTs) cross-links. Previously, we devised a heavy isotope-based PG full labeling method coupled to mass spectrometry to determine the mode of insertion of new-subunits into the expanding PG network (Atze et al., 2022). We showed that PG polymerization operates according to different modes for the formation of the septum and of the lateral cell walls, as well as for bacterial growth in the presence or absence of β-lactams in engineered strains that can exclusively rely on LDTs for PG cross-linking when drugs are present. Here, we apply our method to the resolution of the kinetics of the reactions leading to the covalent tethering of the Braun lipoprotein (Lpp) to PG and the subsequent hydrolysis of that same covalent link. We find that Lpp and disaccharide-peptide subunits are independently incorporated into the expanding lateral cell walls. Newly synthesized septum PG appears to contain small amounts of tethered Lpp. LDTs did mediate intense shuffling of Lpp between PG stems leading to a dynamic equilibrium between the PG-tethered and free forms of Lpp.
Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain
Authors: Estevam Gabriella O , Linossi Edmond M , Macdonald Christian B , Espinoza Carla A , Michaud Jennifer M , Coyote-Maestas Willow , Collisson Eric A , Jura Natalia , Fraser James S
Published: September 2024

MET is a receptor tyrosine kinase (RTK) responsible for initiating signaling pathways involved in development and wound repair. MET activation relies on ligand binding to the extracellular receptor, which prompts dimerization, intracellular phosphorylation, and recruitment of associated signaling proteins. Mutations, which are predominantly observed clinically in the intracellular juxtamembrane and kinase domains, can disrupt typical MET regulatory mechanisms. Understanding how juxtamembrane variants, such as exon 14 skipping (METΔEx14), and rare kinase domain mutations can increase signaling, often leading to cancer, remains a challenge. Here, we perform a parallel deep mutational scan (DMS) of the MET intracellular kinase domain in two fusion protein backgrounds: wild-type and METΔEx14. Our comparative approach has revealed a critical hydrophobic interaction between a juxtamembrane segment and the kinase ⍺C-helix, pointing to potential differences in regulatory mechanisms between MET and other RTKs. Additionally, we have uncovered a β5 motif that acts as a structural pivot for the kinase domain in MET and other TAM family of kinases. We also describe a number of previously unknown activating mutations, aiding the effort to annotate driver, passenger, and drug resistance mutations in the MET kinase domain.
Enhancing intrusion detection performance using explainable ensemble deep learning
Authors: Ben Ncir Chiheb Eddine , Ben HajKacem Mohamed Aymen , Alattas Mohammed
Published: September 2024

Given the exponential growth of available data in large networks, the need for an accurate and explainable intrusion detection system has become of high necessity to effectively discover attacks in such networks. To deal with this challenge, we propose a two-phase Explainable Ensemble deep learning-based method (EED) for intrusion detection. In the first phase, a new ensemble intrusion detection model using three one-dimensional long short-term memory networks (LSTM) is designed for an accurate attack identification. The outputs of three classifiers are aggregated using a meta-learner algorithm resulting in refined and improved results. In the second phase, interpretability and explainability of EED outputs are enhanced by leveraging the capabilities of SHape Additive exPplanations (SHAP). Factors contributing to the identification and classification of attacks are highlighted which allows security experts to understand and interpret the attack behavior and then implement effective response strategies to improve the network security. Experiments conducted on real datasets have shown the effectiveness of EED compared to conventional intrusion detection methods in terms of both accuracy and explainability. The EED method exhibits high accuracy in accurately identifying and classifying attacks while providing transparency and interpretability.
Phytochemical profiling and antioxidant activity assessment of Bellevalia pseudolongipes via liquid chromatography-high-resolution mass spectrometry
Authors: Yolbaş İdris
Published: September 2024

Background

Plant-derived drugs are often preferred over synthetic drugs because of their superior safety profiles. Phenolic compounds and flavonoids—major plant components—possess antioxidant properties. Limited research has been conducted on the bioactive compounds and biochemical properties of Bellevalia pseudolongipes (Asparagaceae), an important pharmacological species endemic to Turkey. Therefore, the chemical composition and antioxidant properties of B. pseudolongipes were investigated in this study.

Methods

The chemical composition of B. pseudolongipes was analyzed using liquid chromatography-high-resolution mass spectrometry, and radical scavenging and antioxidant activities were evaluated using DPPH (2,2-diphenyl-1-picrylhydrazyl) and ABTS (2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid)) tests.

Results

Thirty-eight compounds were identified, including trans-cinnamic acid, caffeic acid, vitexin, schaftoside, orientin, and narirutin. B. pseudolongipes showed high antioxidant activity in antioxidant activity tests.

Conclusion

These findings provide novel insights into the potential utility of B. pseudolongipes in the pharmaceutical, food, and cosmetics industries, highlighted by its significant antioxidant capacity.
Surviving the Added Pressures of the Pandemic: Sexual and Gender Diverse Communities Prioritize Social Connection to Decrease Mental Health Burden During the Covid-19 Pandemic
Authors: Pal Nicole , Huggard Kayla , Card Kiffer G. , Aantjes Carolien , Klassen Ben , Slater Anya , Lachowsky Nathan John
Published: September 2024

This study explored the mental health experiences of sexual and gender diverse (SGD) communities in Canada within the context of the Covid-19 pandemic. Three online focus groups with 14 SGD community members were conducted to discuss experiences with social determinants of mental health. Themes included social connection and support, healthcare access and utilization, discrimination and socioeconomic status (employment, income, housing, education). Social connection and support were prominent themes throughout all groups. Policy and practice should focus primarily on scaling community-led services and programs that build social connection and support informed by local context and perspectives.
Enhancing Transparency and Accountability in Public Service through Open Data Initiatives: Insights from Estonia and Policy Recommendations for the United States
Authors: Okon Samuel Ufom
Published: September 2024

This study addresses the challenge of enhancing transparency and accountability in public governance, focusing on the role of open data initiatives. The study evaluates key aspects of open data initiatives in both Estonia and the U.S., emphasizing the differences and similarities in technological infrastructure, governance structures, data accessibility and quality, and legal frameworks, specifically considering compliance with the International Open Data Charter and the G20 Anti-Corruption Open Data Principles, to draw actionable insights to guide the United States in enhancing transparency and accountability in its public services. The objectives are to analyze how Estonia's open data strategies align with international standards, assess their impact on governance, and identify best practices that could be adapted for the U.S. A combination of multivariate regression, Difference-in-Differences (DiD), time series, and cluster analysis was employed, revealing a significant positive relationship between Estonia's Open Data Initiative Index and its transparency and accountability metrics, with a moderate correlation (R = 0.62). The DiD analysis indicated a modest reduction in corruption, with a 0.15 DiD estimate, following the implementation of open data policies. Time series analysis confirmed the sustainability of Estonia's e-government practices, showing consistent growth across key indicators like the E-Government Development Index, which rose from 0.78 in 2010 to 0.92 in 2022. Cluster analysis positioned Estonia alongside high-performing digital economies like Finland and Denmark. These findings suggest that adopting similar strategies in the U.S. could significantly enhance governance outcomes. By emphasizing a more intensive ICT infrastructure, targeted investments in digital literacy, and a phased implementation approach, the U.S. can foster greater transparency and accountability in public services.
Effects of Different Copper Concentration on Growth and Nodulation of Green Gram (Vigna radiata L.)
Authors: Begum M.M. S. F. Thasreeha , Geretharan T. , Srikrishnah S.
Published: September 2024

An investigation was conducted to study the influence of copper (Cu) on the growth of shoot, root, and nodulation of green gram (Vigna radiata L.). A field pot experiment was designed in a Completely Randomized Design with six treatments and four replicates at Palachcholai, Faculty of Agriculture, Eastern University, Sri Lanka from September to November 2023. Six levels of copper concentration (control, 50, 100, 150, 200, 250 mg copper/kg soil) was applied to the soil in the form of copper sulphate (CuSO4.5H2O) in which the green gram plants were grown. Exposure to copper at concentrations ranging from 100-250 mg copper/kg soil reduced total chlorophyll content, shortened root length, decreased plant biomass, and produced fewer leaves, and a lower number of nodules. Conversely, exposure to copper at 50 mg copper/kg soil increased the fresh shoot biomass, soil microbial respiration and soil pH. Additionally, the positive effects of copper were observed on tap root length, leaf area, and root volume. The copper at 50 mg copper/kg soil concentration enhanced the shoot biomass, the number of nodules and soil microbial respiration by 25% ,14%, and 22% respectively compared to the control while the copper concentrations ranging from 100 mg copper/kg soil to 250 mg copper/kg soil significantly inhibited the overall growth and nodule formation of green gram. The results clearly indicate that Cu is an important micro-nutrient, only it should be added in trace amount to induce plant growth and other physiological processes. However, copper at higher concentrations can act as a heavy metal and cause phyto-toxicity on plants.
Impact of Organic Amendments on Entomopathogenic Nematodes: An Overview
Authors: Devi Gitanjali
Published: September 2024

Healthy soil enhances crop yield. In order to increase the organic matter content of soil for sustainable and healthy soil, organic amendments are applied in the field. Build-up of insect pest populations under organic production system is problematic which not only reduces yield but also lowering crop quality. Integrated Pest Management (IPM) strategies that incorporate cultural management, biological management, use of resistant varieties are viable options for reduction of pest population. Among the biocontrol agents, Entomopathogenic nematodes (EPNs) are efficacious against various insect pests in a variety of habitats. However, the effectiveness of EPNs against insect pests is largely dependent on the method of application and nematode survival under field conditions. Cultural management practice such as application of organic amendments can alter the soil health that enables their occurrence and activity. Understanding the interactions is essential to reveal ways to enhance the potential of EPNs as biocontrol agents in a particular soil type, environmental condition and agricultural scenario. This review provides a brief overviews of impact of organic amendments on EPNs from the standpoint of pest management.
Solid-state Batteries: Overcoming Challenges and Harnessing Opportunities for a Sustainable Energy Future
Authors: Arum Chinaecherem Tochukwu , Bbumba Simon , Kigozi Moses , Karume Ibrahim , Nsubuga Hakimu , Kato Maximillian , Kiganda Ivan , Sekandi Peter , Yikii Collins Letibo , Ntale Muhammad
Published: September 2024

Herein we reviewed solid-state batteries (SSBs) as an emerging and promising alternative to conventional lithium-ion batteries, offering enhanced energy density, safety, and longevity. Solid-state batteries (SSBs) use a solid electrolyte instead of the liquid or gel electrolytes found in conventional lithium-ion batteries. SSBs can achieve energy densities of up to 500 Wh/kg, compared to 350 Wh/kg for conventional lithium-ion batteries. This paper explores the potential of SSBs to revolutionize grid stability and energy storage. The unique characteristics of SSBs, including their solid-state electrolytes (SSEs) and absence of liquid components, significantly mitigate safety concerns associated with traditional batteries. Moreover, SSBs exhibit higher faster charging rates, making them ideal for applications demanding high energy storage capacity and rapid response times. The paper further discusses the key challenges and advancements in SSB development, including material selection, manufacturing processes, and cost reduction. It also highlights the anode and cathode materials but also the interface challenges faced during the design and development of SSBs. By addressing the limitations of current energy storage solutions, SSBs offer a promising pathway toward a more resilient and sustainable energy future.
The role of surface basic amino acids of dengue virus NS3 helicase in viral RNA replication and enzyme activities
Authors: Chiang Pao‐Yin , Wu Huey‐Nan
Published: June 2016

Structure‐based mutagenesis analysis on selected conserved surface basic residues of DENV NS3 helicase was performed using a selectable replicon and recombinant protein. We found a requirement for basic side chains of NS3 residues #225, #268, and #538 to activate viral RNA replication and ensure RNA‐stimulated ATPase activity, and a critical role for R560 and R599 residues in maintaining NS3 helicase structure, linked to its biological function and catalytic activity. Three screened NS3 second‐site mutations for R225A and R268A/E mutations elevated the functional RNA binding of NS3 helicase and compensated the replication defect of the original NS3 mutant replicons.
Neutral density estimation derived from meteoroid measurements using high‐power, large‐aperture radar
Authors: Li A. , Close S.
Published: June 2016

We present a new method to estimate the neutral density of the lower thermosphere/upper mesosphere given deceleration measurements from meteoroids as they enter Earth's atmosphere. By tracking the plasma (referred to as head echoes) surrounding the ablating meteoroid, we are able to measure the range and velocity of the meteoroid in 3‐D. This is accomplished at Advanced Research Projects Agency Long‐Range Tracking and Instrumentation Radar (ALTAIR) with the use of four additional receiving horns. Combined with the momentum and ablation equations, we can feed large quantities of data into a minimization function which estimates the associated constants related to the ablation process and, more importantly, the density ratios between successive layers of the atmosphere. Furthermore, if we take statistics of the masses and bulk densities of the meteoroids, we can calculate the neutral densities and its associated error by the ratio distribution on the minimum error statistic. A standard deviation of approximately 10% can be achieved, neglecting measurement error from the radar. Errors in velocity and deceleration compound this uncertainty, which in the best case amounts to an additional 4% error. The accuracy can be further improved if we take increasing amounts of measurements, limited only by the quality of the ranging measurements and the probability of knowing the median of the distribution. Data analyzed consist mainly of approximately 500 meteoroids over a span of 20 min on two separate days. The results are compared to the existing atmospheric model NRLMSISE‐00, which predicts lower density ratios and static neutral densities at these altitudes.
Understanding the link between circumferential dikes and eruptive fissures around calderas based on numerical and analog models
Authors: Corbi Fabio , Rivalta Eleonora , Pinel Virginie , Maccaferri Francesco , Acocella Valerio
Published: June 2016

Active calderas are seldom associated with circumferential eruptive fissures, but eroded magmatic complexes reveal widespread circumferential dikes. This suggests that, while the conditions to emplace circumferential dikes are easily met, mechanisms must prevent them from reaching the surface. We explain this discrepancy with experiments of air injection into gelatin shaped as a volcano with caldera. Analog dikes show variable deflection, depending on the competition between overpressure, Pe, and topographic unloading, Pl; when Pl/Pe = 4.8–5.3, the dikes propagate orthogonal to the least compressive stress. Due to the unloading, they become circumferential and stall below the caldera rim; buoyancy is fundamental for the further rise and circumferential fissure development. Numerical models quantitatively constrain the stress orientation within the gelatin, explaining the observed circumferential dikes. Our results explain how dikes propagate below the rim of felsic and mafic calderas, but only in the latter they are prone to feed circumferential fissures.
Interannual similarity in the Martian atmosphere during the dust storm season
Authors: Kass D. M. , Kleinböhl A. , McCleese D. J. , Schofield J. T. , Smith M. D.
Published: June 2016

We find that during the dusty season on Mars (southern spring and summer) of years without a global dust storm there are three large regional‐scale dust storms. The storms are labeled A, B, and C in seasonal order. This classification is based on examining the zonal mean 50 Pa (∼25 km) daytime temperature retrievals from TES/MGS and MCS/MRO over 6 Mars Years. Regional‐scale storms are defined as events where the temperature exceeds 200 K. Examining the MCS dust field at 50 Pa indicates that warming in the Southern Hemisphere is dominated by direct heating, while northern high latitude warming is a dynamical response. A storms are springtime planet encircling Southern Hemisphere events. B storms are southern polar events that begin near perihelion and last through the solstice. C storms are southern summertime events starting well after the end of the B storm. C storms show the most interannual variability.
More stable yet bimodal geodynamo during the Cretaceous superchron?
Authors: Lhuillier Florian , Gilder Stuart A. , Wack Michael , He Kuang , Petersen Nikolai , Singer Brad S. , Jicha Brian R. , Schaen Allen J. , Colon Dylan
Published: June 2016

We report palaeomagnetic and40Ar/39Ar dating results from two sequences of basaltic lava flows deposited at the same locality in western China, yet separated in time by ~50 Myr: one set lies within the Cretaceous normal superchron at 112–115 Ma and a second at 59–70 Ma spanning the Cretaceous‐Palaeogene boundary. We find that magnetic field directions during the superchron exhibit bimodal populations: one with inclinations representative of a dipolar field and another with shallow inclinations that could reflect a more complex, multipolar field. However, the time‐dependent variability in field directions was 50% lower during the superchron than after, which implies greater field stability during the superchron. Our results suggest that episodes of less dipolar field behavior occurred within the Cretaceous superchron and raise the question whether a second, more multipolar, field state is more persistent than previously thought.
Crustal magnetization and the subseafloor structure of the ASHES vent field, Axial Seamount, Juan de Fuca Ridge: Implications for the investigation of hydrothermal sites
Authors: Caratori Tontini Fabio , Crone Timothy J. , de Ronde Cornel E. J. , Fornari Daniel J. , Kinsey James C. , Mittelstaedt Eric , Tivey Maurice
Published: June 2016

High‐resolution geophysical data have been collected using the Autonomous Underwater Vehicle (AUV) Sentry over the ASHES (Axial Seamount Hydrothermal Emission Study) high‐temperature (~348°C) vent field at Axial Seamount, on the Juan de Fuca Ridge. Multiple surveys were performed on a 3‐D grid at different altitudes above the seafloor, providing an unprecedented view of magnetic data resolution as a function of altitude above the seafloor. Magnetic data derived near the seafloor show that the ASHES field is characterized by a zone of low magnetization, which can be explained by hydrothermal alteration of the host volcanic rocks. Surface manifestations of hydrothermal activity at the ASHES vent field are likely controlled by a combination of local faults and fractures and different lava morphologies near the seafloor. Three‐dimensional inversion of the magnetic data provides evidence of a vertical, pipe‐like upflow zone of the hydrothermal fluids with a vertical extent of ~100 m.
A telescopic and microscopic examination of acceleration in the June 2015 geomagnetic storm: Magnetospheric Multiscale and Van Allen Probes study of substorm particle injection
Authors: Baker D. N. , Jaynes A. N. , Turner D. L. , Nakamura R. , Schmid D. , Mauk B. H. , Cohen I. J. , Fennell J. F. , Blake J. B. , Strangeway R. J. , Russell C. T. , Torbert R. B. , Dorelli J. C. , Gershman D. J. , Giles B. L. , Burch J. L.
Published: June 2016

An active storm period in June 2015 showed that particle injection events seen sequentially by the four (Magnetospheric Multiscale) MMS spacecraft subsequently fed the enhancement of the outer radiation belt observed by Van Allen Probes mission sensors. Several episodes of significant southward interplanetary magnetic field along with a period of high solar wind speed (Vsw ≳ 500 km/s) on 22 June occurred following strong interplanetary shock wave impacts on the magnetosphere. Key events on 22 June 2015 show that the magnetosphere progressed through a sequence of energy‐loading and stress‐developing states until the entire system suddenly reconfigured at 19:32 UT. Energetic electrons, plasma, and magnetic fields measured by the four MMS spacecraft revealed clear dipolarization front characteristics. It was seen that magnetospheric substorm activity provided a “seed” electron population as observed by MMS particle sensors as multiple injections and related enhancements in electron flux.
The impact of energetic electron precipitation on mesospheric hydroxyl during a year of solar minimum
Authors: Zawedde Annet Eva , Nesse Tyssøy Hilde , Hibbins Robert , Espy Patrick J. , Ødegaard Linn‐Kristine Glesnes , Sandanger Marit Irene , Stadsnes Johan
Published: June 2016

In 2008 a sequence of geomagnetic storms occurred triggered by high‐speed solar wind streams from coronal holes. Improved estimates of precipitating fluxes of energetic electrons are derived from measurements on board the NOAA/POES 18 satellite using a new analysis technique. These fluxes are used to quantify the direct impact of energetic electron precipitation (EEP) during solar minimum on middle atmospheric hydroxyl (OH) measured from the Aura satellite. During winter, localized longitudinal density enhancements in the OH are observed over northern Russia and North America at corrected geomagnetic latitudes poleward of 55°. Although the northern Russia OH enhancement is closely associated with increased EEP at these longitudes, the strength and location of the North America enhancement appear to be unrelated to EEP. This OH density enhancement is likely due to vertical motion induced by atmospheric wave dynamics that transports air rich in atomic oxygen and atomic hydrogen downward into the middle atmosphere, where it plays a role in the formation of OH. In the Southern Hemisphere, localized enhancements of the OH density over West Antarctica can be explained by a combination of enhanced EEP due to the local minimum in Earth's magnetic field strength and atmospheric dynamics. Our findings suggest that even during solar minimum, there is substantial EEP‐driven OH production. However, to quantify this effect, a detailed knowledge of where and when the precipitation occurs is required in the context of the background atmospheric dynamics.