bluuebunny/crossref_metadata_2025 huggingface dataset:
Indeterminate (B3) breast lesions: experience with vacuum-assisted biopsy under ultrasound guidance
Authors: Busko E. A. , Mortada V. V. , Krivorotko P. V. , Semiglazov V. F. , Pesotsky R. S. , Emelyanov А. S. , Amirov N. S. , Channov V. S. , Tabagua T. T. , Gigolaeva L. P. , Yerechshenko S. S. , Komyakhov A. V. , Nikolaev K. S. , Zernov K. Y. , Zhiltsova E. K. , Bondarchuk Ya. I. , Enaldieva D. A.. , Novikov S. N. , Apollonova V. S. , Tseluiko A. I. , Kasparov B. S.
Published: October 2022

INTRODUCTION: Introduction of breast cancer screening programs has led to an increase in detection of non-palpable masses requiring core needle biopsy. Masses that fall into B3 category based on the histological results of core biopsy specimens, are of interest precisely because of their uncertain malignant potential and the lack of a final consensus on their management.

OBJECTIVE: To analyze the 3-year experience of ultrasound guided vacuum-assisted biopsy (VAB) in patients with B3 breast lesions based on the results of histological examination of core biopsy specimens.

MATERIALS AND METHODS: Between June 2019 and June 2022, 163 VABs were performed. The study group included patients with category 2–4 breast lesions according to the BI-RADS scoring system. The decision to perform VAB was made by the oncologist in each specific case on the basis of anamnesis, clinical data and the results of core biopsy histological examination: in cases of B3 or B2 lesions with a discordant radiologic pattern.

RESULTS: In 155 (95.0%) cases, the removed lesions were benign, invasive cancer was detected in 2 (1.2%) cases, ductal cancer in situ in 6 cases (3.8%). The сomplications included: in 5 (3.1%) cases, patients had pain after the procedure, and in 37 (22.7%) cases there was a hematoma. In 5 (3.1%) patients, residual tissue was found at the site of removed lesions. CONCLUSIONS: VAB is a safe alternative to exploratory surgery in patients with B3 lesions diagnosed by core biopsy.
Simple and practical DIQKD security analysis via BB84-type uncertainty relations and Pauli correlation constraints
Authors: Masini Michele , Pironio Stefano , Woodhead Erik
Published: October 2022

According to the entropy accumulation theorem, proving the unconditional security of a device-independent quantum key distribution protocol reduces to deriving tradeoff functions, i.e., bounds on the single-round von Neumann entropy of the raw key as a function of Bell linear functionals, conditioned on an eavesdropper's quantum side information. In this work, we describe how the conditional entropy can be bounded in the 2-input/2-output setting, where the analysis can be reduced to qubit systems, by combining entropy bounds for variants of the well-known BB84 protocol with quantum constraints on qubit operators on the bipartite system shared by Alice and Bob. The approach gives analytic bounds on the entropy, or semi-analytic ones in reasonable computation time, which are typically close to optimal. We illustrate the approach on a variant of the device-independent CHSH QKD protocol where both bases are used to generate the key as well as on a more refined analysis of the original single-basis variant with respect to losses. We obtain in particular a detection efficiency threshold slightly below 80.26%, within reach of current experimental capabilities.
La normativa sobre el plagio en las universidades públicas costarricenses
Authors: Salas Acuña Erick F. , Amador Solano María Gabriela
Published: October 2022

Se presenta una reflexión en torno al plagio en las universidades públicas costarricenses. La investigación consiste en un análisis de contenido de los documentos normativos recolectados de cada una de las cinco universidades públicas de Costa Rica (Universidad de Costa Rica, Tecnológico de Costa Rica, Universidad Nacional, Universidad Estatal a Distancia y Universidad Técnica Nacional) mediante una búsqueda en línea de las páginas de estas instituciones. El plagio representa un problema complejo para la educación superior que demanda acciones orientadas a fortalecer los procesos de penalización, detección y prevención. Desde el punto de vista normativo, las universidades han establecido medidas para regular diversas formas de deshonestidad académica, entre ellas el plagio académico. El análisis realizado muestra que, si bien las universidades públicas cuentan con artículos sobre el tema dentro de sus reglamentos, existen importantes diferencias relacionadas con las definiciones, la gravedad de las faltas y las sanciones relacionadas. Al final, el artículo propone algunos de los desafíos que enfrentan las universidades para contribuir aún más a la prevención del plagio.
Exploring the antecedents and consequences of firm-stakeholder engagement process: A systematic review of literature
Authors: Singh Avinash Pratap , Rahman Zillur
Published: October 2022

The extant business and management literature have primarily viewed stakeholder engagement (SE) as an activity and centred on exploring the methods of firm-stakeholder interactions. Some scholars have studied SE as a process and examined its components (Hoffmann & Lutz, 2015; Lane & Devin, 2018). However, current investigations of the antecedents and consequences of SE processes are fragmented and mainly focused on either company or stakeholder context. In this systematic review, we pursued the vast body of literature on firm-stakeholder engagement and comprehensively examined over 170 research articles to accumulate precursors and outcomes of SE processes. Our work has two unique properties: first, it consolidates the knowledge of the antecedents and consequences of SE processes to generate a holistic view of the firm-stakeholder relationships. Second, it explores the existence of business practices in instrumental and normative dimensions using the concept of “continuum” to provide deeper insights into the SE processes. We used thematic analysis to provide evidence of the growing interest of academics and managers in firm-stakeholder engagement. The findings of this study suggest that shared benefits with a long-term perspective are valuable to both corporation and its stakeholders. In this critical analysis of the SE literature, we also provide implications for researchers and practitioners
Performance, Competence, Job Satisfaction, and Financial Compensation of Cosmetics Salesforce during the COVID-19 Outbreak
Authors: Suseno Bambang Dwi , Sofa Indah Hartini , Widayanto Mohammad Tri , Basrowi Basrowi
Published: October 2022

The COVID-19 pandemic caused a decrease in sales turnover for the cosmetic industry, causing salesforce performance to be unsatisfactory. The study developed a model to improve the performance of the cosmetics industry in Banten Province of Indonesia. This quantitative study employed SmartPLS 3.3.2 version to analyze the data obtained from 120 respondents through observations and questionnaire. The results of the empirical model with SEM-PLS revealed that competence has a significant positive effect on financial compensation, competence has a significant positive effect on salesforce job satisfaction, salesforce job satisfaction has a significant positive effect on salesforce performance, financial compensation has no effect on salesforce performance, and salesforce performance has no effect on financial compensation. It is recommended that the cosmetic industry recalculate the amount of compensation appropriately according to measurable performance to yield an impact on salesforce performance. This study highlights the importance of competence-based compensation for fostering self-improvement of employee.
Effect of blue diode laser intensity on welding of pure copper wire using blue-IR hybrid laser
Authors: Fujio Shumpei , Takenaka Keisuke , Sato Yuji , Ito Rika , Hori Eiji , Tsukamoto Masahiro
Published: October 2022

A welding of a pure copper wire was conducted with a hybrid laser system, which combines a blue laser and an infrared (IR) laser to achieve a highly efficient and spatterless laser welding of pure copper. In the experiment, a blue-IR hybrid laser was irradiated onto a 3 × 3 × 20 mm3 pure copper wire, and the intensity of the blue laser was varied to clarify the effect of the combining of the blue diode laser. While irradiating the laser, the sample was observed by using a high-speed video camera, and the temperature of the processing point was measured by using a thermal camera. After laser irradiation, a molten volume and welding efficiency was evaluated. It was clarified that the welding efficiency of the pure copper wire increased as the intensity of the blue laser increased. At the maximum, the welding efficiency with a 6.31 × 107 W/cm2 IR laser became 1.88 times higher by combining a 9.98 × 105 W/cm2 blue laser. This finding can contribute to a further increase in the welding efficiency of pure copper wires, leading to high production efficiency in the pure copper welding process.
Gripes mulighetene? Om lesestunder med de yngste barna i barnehagen
Authors: Dybvik Hilde , Fodstad Cecilie D. , Jæger Henriette
Published: October 2022

Studien retter seg mot høytlesningspraksiser i barnehagen, og belyser samspillet rundt bøker som finner sted mellom barnehageansatte og barn, avgrenset til småbarn (0–3 år). Til grunn for diskusjonene er et videomateriale på 27 ti-minutters sekvenser. Filmene stammer fra forskningsprosjektet Blikk for barn (2012–2017), og viser ulike situasjoner på småbarnsavdelinger med varierende samspill rundt bøker. Artikkelen undersøker hvordan og i hvilken grad personalet griper mulighetene for å skape lesestunder med de yngste barna og slik oppnå felles oppmerksomhet – «joint attention» (Tomasello, 1999). Funnene viser at det bare i seks av de 27 videosekvensene dannes en lesestund med felles oppmerksomhet. Forholdet mellom den ansattes rolle og ansvar som litteraturformidler på den ene siden, og barns medvirkning på den andre, er sentralt i diskusjonen. Artikkelen argumenterer for at det å legge til rette for felles oppmerksomhet kan være en måte å sørge for barns medvirkning på, fordi det innebærer å fange opp hva de yngste barna, med sin multimodale uttrykksform (Thuresson, 2021), engasjerer seg i, og anerkjenne at en lesestund er en verdifull fellesaktivitet som ikke etableres av seg selv.
English abstract
Seizing the opportunities? Story time with toddlers in kindergarten
This study examines reading practices in Early Childhood Eduacation and Care (ECEC) with focus on interactions taking place between the pedagogical staff and children in different reading situations, limited to young children (0–3 years). The discussions are based on a video material of 27 ten-minute sequences where all orginate from the research project Searching for qualities. All the sequences include pedagogical staff and children under the age of three dealing with books in some way. The article investigates how, and to what extent, the staff seizes the opportunities for a story time to take place and thereby achieve «joint attention» (Tomasello, 1999). A result is that story times with joint attention only occur in six of the sequences. The relationship between, on one hand, the employee’s role and responsibility as a storyteller and, on the other, children’s participation, is a central part of the discussion. The article argues that facilitating joint attention can be a way to ensure children’s participation. This is because it involves capturing what the youngest children, with their multimodal form of expression (Thuresson, 2021), engage in and recognize. We argue that a story time is a valuable joint activity, but that it is not established without an effort.
Pelatihan Penulisan dan Publikasi Artikel Ilmiah bagi Guru-Guru Sekolah Dasar
Authors: Widiana I Wayan , Tristiantari Ni Ketut Desia , Rediani Ni Nyoman , Yudiana Kadek Edi , Sari Ni Made Daini Vitri Sinta
Published: October 2022

Guru-guru sekolah dasar masih mengalami banyak hambatan dan kendala dalam penulisan karya ilmiah serta publikais ilmiah diperlukan sebagai syarat kenaikan pangkat. Pengabdian ini bertujuan untuk memberikan pemahaman guru tentang teknik penulisan karya ilmiah dan tentang cara dan sistematikan publikasi ilmiah.  Metode yang digunakan adalah In Service Training melalui metode ceramah, diskusi, presentasi, dan On Service Training melalui pendampingan melakukan perencanaan penelitian; melakukan progress report; menulis artikel ilmiah; dan pendampingan melakukan submit jurnal. Hasil dari pengabdian ini adalah peserta mampu memahami konsep artikel ilmiah dan dapat membuat artikel ilmiah yang siap publish pada jurnal-jurnal nasional terakreditasi. Kegiatan ini dikatakan berhasil karena pemahaman peserta terkait materi meningkat, respon peserta terhadap kegiatan ini sangat positif, dan terdapat salah satu guru yang mampu menulis artikel ilmiah dan siap publish di salah satu jurnal nasional terakreditasi.
Nutritional Properties of Yard Long Bean Cultivars in Bangladesh
Authors: Khatun Anjumanara , Quamruzzaman A.K.M. , Islam Ferdouse , Akter Limu , Khanom Anjuman Ara
Published: October 2022

The purpose of the study was to compare the nutritional composition [carbohydrate, protein, moisture content, fat, ash, sugar, crude fiber] of four yard long bean cultivars in Bangladesh between 2020 and 21. Consumption of foods high in nutritional value offers a variety of anti-diabetic, anti-heart disease, and anti-cancer effects. The cultivars were high in different proximate composition, the cultivars evaluated had an energy content of 45.86 to 37.21 Kcal/100 g, a carbohydrate content of 6.20 to 8.33 g/100 g, a protein content of 2.72 to 3.22 g/100 g, a fat content of 0.10 to 0.18 g/100 g, a sugar content of 1.52 to 2.37 g/100 g, and a crude fiber content of 1.17 to 1.79 g/100 g. As a result, the cultivars under investigation could be recommended as a nutritional source in daily diets and could be used to treat coronary heart disease, diabetes, intestinal disorders, prostate, stomach ailments, and some cancer kinds.
The Development of Basic Arabic E-Module Using Fliphtml5 as Alternative Teaching Material
Authors: Amin Nur Fadilah , Tadjuddin Andi Fajriwati , Nasruni Nasruni , Hidayah Nurul
Published: October 2022

To improve learning activities in the Arabic course for students of Universitas Muhammadiyah Makassar in this pandemic period, digital teaching materials are needed. The development of the basic Arabic language in this university is important because Arabic is one the courses taught in almost every study program. The method that was used to develop this electronic module is the 4D method which consists of the Define, Design, Develop, and Disseminate stage. The data sources in this development are divided into two parts. The first data sources relating to the development of books are taken from Arabic books while the data sources used as test subjects are 43 students of the Islamic Economics Study Program, Faculty of Economics and Business, Universitas Muhammadiyah Makassar. The results of this development were an electronic module using Fliphtml5 as a development design template while the method of presenting material in this E-Module follows the model of the Directorate general of Islamic religious institution and open university modules in 1996. Which begins with an introduction, and contains learning activities, exercises and summeries. The percentage of the respondents reached 92% and 96% which explains to us that the material of the Arabic E-Module is easier to understand as an alternative teaching materials for this course. Then as a conclusion of the result, this E-Module can be used as teaching materials to improve Arabic learning activities.
Educational behavior of the students in the design studios during the pandemic time
Authors: TAFAHOMİ Rahman
Published: October 2022

The main aim of this paper is to demonstrate the process of adapting architecture students to the pandemic condition in the design studios due to wearing face masks and social distance measures. An architectural design studio is different from a normal classroom due to the open space for open discussion and dialogue and group work. The methodology of the research was designed based on the quantitative method with the application of the Likert scale questionnaire and analyzing the data in SPSS. The findings of the research identified that three factors are important for the students in the activities in the design studios including desk-crits (critique), social interaction, and the physical environment of the design studios. The Chi-square analysis illustrated that the students preferred to use the individual desk-crits over group desk-crits during the pandemic time due to wearing face masks and social distance. Apparently, public activities such as presentations, communication, and discussion were replaced with the individual desk-crits as a more adapted form to wearing face masks and social distance for the students in terms of personalization of the learning process in design studios during the pandemic time.
Enfermedad, sufrimiento, pensamiento. Nietzsche y la existencia humana
Authors: Scolari Paolo
Published: October 2022

Thomas Mann afirma que Nietzsche tiene también otro nombre: enfermedad. De hecho, cuando se mira a la vida del filósofo de Röcken, es imposible no toparse con su patología: más allá de la locura delirante que marca la última década, toda su existencia aparece indeleblemente marcada por la enfermedad. Y en Nietzsche el tema autobiográfico de la enfermedad es inseparable del problema filosófico del sufrimiento. Aprovechando su experiencia como eterno enfermo, Nietzsche desea experimentar hasta qué punto el pensamiento puede resistir y qué dirección toma cada vez que está sometido a la presión del mal. Sus reflexiones mordaces muestran cómo lo negativo no puede ser erradicado de la existencia, mucho menos justificado, pero constituye un ingrediente necesario: sin lágrimas, el hombre perdería demasiadas alegrías y nunca llegaría a reírse.
The Question of Human Suffering in Nietzsche
Authors: Tuncel Yunus
Published: October 2022

Suffering and how one relates to one's own and others' sufferings are important themes in Nietzsche's works from the first to the last, as I examined in my recent monograph, Human Emotions in Nietzsche (Basel: Schwabe, 2021). In this article, I will build on what I wrote on this subject in this book and elsewhere, as I examine five paradigms for dealing with suffering, which I name: aesthetic, critical/historic, emotional, power, and transfiguration. Although these paradigms and the ideas that support them are present in Nietzsche's works and many Nietzsche readers may be aware of them, their organization in this form has appeared to me during the pandemic. I do not claim that these paradigms form a complete picture, but I believe they are sufficient to give us a broad picture of Nietzsche's teachings on suffering.
Clinical outcomes of predoctoral implant dentistry education: A Systematic Review.
Authors: Nagpal Disha , Flores-Mir Carlos , Nassar Usama , Levin Liran
Published: October 2022

Objectives: To systematically synthesize the status of predoctoral implant dental education in terms of clinical outcomes including implant success and survival of them when placed by predoctoral students.

Materials and methods: A thorough search was carried out up to February 2019 using Medline (OVID), EMBASE, ERIC, and Web of Science electronic databases. In addition to this, bibliographies of the potentially eligible articles were searched manually. Abstracts that seemed to satisfy the initial selection criteria were selected for the recovery of the full text. The full-text risk of bias assessment was then done, in line with the selection criteria by two reviewers. The selected articles were evaluated using the Joanna Briggs Institute (JBI) Critical Appraisal tools. The GRADE approach was adapted, but not validated, for observational studies to assess the certainty of evidence.

Results: Overall, 15 articles were included. Most of the reported implants were used to support mandibular overdentures or single unit implants and their survival rates were found to be generally favorable. Only a few studies also used patient satisfaction surveys which displayed overall satisfaction, suggesting that the dental implant treatment may be adequately provided in school settings.

Clinical significance: The success and survival of the implant’s type done in an undergraduate classroom setting is indicative of the undergraduate dental implant curriculum. Based on this work, it can be concluded that the success and survival of such implants appear to be reasonable and most of the patients getting an implant at the school were satisfied.
The Microbially Extended Phenotype of Plants, a Keystone against Abiotic Stress
Authors: Ruiz-González Mario X. , Vicente Oscar
Published: October 2022

Background: Climate change affects every region across the globe with heterogeneous effects on local temperatures and precipitation patterns. In plants, sessile organisms, climate change imposes more drastic effects leading to loss of yield or even death. However, plants establish mutualistic interactions with microorganisms that boost plant tolerance against abiotic stresses or strengthen the plant immune system against pathogens, thus, enhancing their survival and fitness. Moreover, in the wild, microbial endophytes provide important ecosystem services.

Purpose and scope: Little we know about the mechanisms of response against the adverse effects of climate change on natural populations of wild plants and even less about the potential role played by microbial biostimulants. In this article, we review the effects of biostimulants on plant responses against abiotic stresses, with a particular focus on the role of mycorrhizas and leaf endophytes.

Results: We have reviewed the effects of the main abiotic stresses in plants, the mechanisms that plants use to face these abiotic challenges, and the interaction plant-biostimulant-abiotic stress, highlighting the primary responses and parameters to evaluate different plant responses.

Conclusion: Abiotic stresses can check the phenotypic plasticity of plants and also trigger a complex and heterogeneous array of responses to face different abiotic stresses, and beneficial microorganisms do play an essential role in enhancing such responses. Our laboratory has initiated a project to characterise microbial populations associated with plants from wild areas and analyse their potential role in aiding the plants to cope with abiotic stresses.
Influence of intercultural competence on an organisation’s success and personal career: the case study of Lithuania
Authors: Adamoniene Ruta , Blašková Martina , Petrauskiene Ruta , Rauleckas Rimantas
Published: October 2022

This paper aims to identify the influence of intercultural competence on an organisation’s success and personal career in Lithuania. The study described in this paper is a part of international research on intercultural competence. An online questionnaire survey was conducted in Lithuania with non-probability convenience sampling to find out the views of employees working in different sector organisations. The survey was filled out by 1193 respondents from Lithuania. Employees’ intercultural competence (knowledge/cognitive dimension, skills/behavioural dimension, and attitudes/emotional dimension) was evaluated using 5-point Likert items and is elaborated elsewhere. The multivariate analysis was used to analyse the survey data and test three hypotheses stating that (1) employees support the notion that higher intercultural competence can foster an organisation’s success and personal career, (2) organisations tend to leave the development of intercultural competence to employees, and (3) current intercultural knowledge and skills are inadequate to operate in a multicultural work environment. The analysis showed that half of the respondents agreed with the statement that the development of intercultural competence (ICC) helped the personal career and an organisation’s success. The statement regarding organisations tending to leave the intercultural competence development to their employees was only supported by less than one-third of the respondents. Besides, the data did not fully support the statement that employees’ current intercultural knowledge and skills were inadequate to operate in a multicultural work environment, as no more than one-third of the respondents had frequent or very frequent issues when communicating with foreigners due to inadequate intercultural knowledge and skills in various sub-areas. The paper elaborates on detailed results.
Collective creativity in management science
Authors: Ciachorowski Damian , Lis Anna Maria
Published: October 2022

This paper aims to establish the current state of knowledge on collective creativity in management science based on a systematic literature review. A systematic review was performed based on the three-step SPL procedure proposed by Tranfield et al. (2003). Two databases (Scopus and Web of Science) were searched electronically until March 2022. Literature analysis and content analysis were performed based on the secondary data. Eighteen studies met the inclusion criteria following the systematic literature review procedure. The conducted descriptive and thematic analysis allowed establishing the state of knowledge in the analysed area and identifying the main thematic areas along with the future research directions. The research was the first to conduct a systematic literature review (SLR) on collective creativity in management science. The main contribution of this paper is its exclusive focus on analysing existing research in the collective creativity field, limited to management science. SLR allowed determining that research in the analysed area was still at a fairly early stage. Although the existing literature sheds some light on collective creativity, studies investigating the aspects of teamwork focused on problem-solving are required.
Pathophysiological and clinical aspects of the circadian rhythm of arterial stiffness in diabetes mellitus: A minireview
Authors: Serhiyenko Victoria A. , Serhiyenko Ludmila M. , Sehin Volodymyr B. , Serhiyenko Alexandr A.
Published: October 2022

Several cross-sectional trials have revealed increased arterial stiffness connected with the cardiac autonomic neuropathy in types 2 and 1 diabetic patients. The pathophysiological relationship between arterial stiffness and autonomic dysfunction in diabetes mellitus is still underinvestigated and the question whether the presence of cardiac autonomic neuropathy leads to arterial stiffening or increased arterial stiffness induced autonomic nervous system impairment is still open. Both arterial stiffness and dysfunction of the autonomic nervous system have common pathogenetic pathways, counting state of the chronic hyperinsulinemia and hyperglycemia, increased formation of advanced glycation end products, activation of protein kinase C, development of endothelial dysfunction, and chronic low-grade inflammation. Baroreceptor dysfunction is thought to be one of the possible reasons for the arterial wall stiffening development and progression. On the contrary, violated autonomic nervous system function can affect the vascular tone and by this way alter the large arteries walls elastic properties. Another possible mechanism of attachment and/or development of arterial stiffness is the increased heart rate and autonomic dysfunction corresponding progression. This minireview analyzes the current state of the relationship between the diabetes mellitus and the arterial stiffness. Particular attention is paid to the analysis, interpretation, and application of the results obtained in patients with type 2 diabetes mellitus and diabetic cardiac autonomic neuropathy.
Manifestations of Sustainable Development in China: Based on Policy Study
Authors: Wu Yue , Zhong Xinzhi
Published: October 2022

Subject and purpose of work: This article aims to better understand China’s actions and challenges encountered in sustainable development due to the COVID-19 crisis, economic difficulties, and the war between Russia and Ukraine. It also aims to provide valuable recommendations for China or other countries concerning future sustainable development work.

Materials and methods: We reviewed extensive literature and made a policy content analysis as the research methodology.

Results: We concluded that China has put emphasis on sustainable development since ancient times. China has made notable progress in sustainable development both domestically inside China and worldwide. However, China also faces challenges related to sustainable development within China itself.

Conclusions: Although China has launched effective policies that have received positive feedback, there is still a long way to go to achieve truly sustainable development. We suggest that all countries, regions, and individuals take a joint action in order to achieve a sustainable planet for us and future generations.
The interrelation between otorhinolaryngology and orthodontics in solving malocclusion and facial dysmorphisms caused by chronic adenotonsillitis
Authors: Cobzeanu Bogdan Mihail , Palade Dragos Octavian , Bandol Gianina , Rusu Daniela , Severin Florentina , Rosu Andrei , Roman Andrei , Vlad Andreea , Mocanu Florin , Cobzeanu Mihail Dan , Cobzeanu Maria Luiza , Zetu Irina , Iacob Mihnea
Published: October 2022

OBJECTIVES. The aim of this study was to reevaluate the implication of early diagnosis of chronic adenoid syndrome and tonsillar hypertrophy in the prophylaxis and control of facial and dental deformities in children.

MATERIAL AND METHODS. The authors conducted a prospective study on 42 paediatric patients with chronic adenoid syndrome admitted in the ENT and Orthodontic Departments of “Sf. Spiridon” Emergency Hospital and “Sf. Maria” ENT Paediatric Department, Iasi, treated in collaboration with orthodontic and logopaedic specialists, with follow-up on the improvement of symptomatology and morphofunctional deficiencies.

RESULTS. Late diagnosis and treatment of the obstructive adenoid hypertrophy can cause difficulty in managing cases, consequently maintaining the aesthetic deficiencies and morphofunctional disorders within a follow-up period of 2 years. Furthermore, we present the chronic complications due to obstructive adenoid hypertrophy (rhinosinusal and ear-related diseases, obstructive sleep apnea), as well as the progression of these cases after interdisciplinary approach.

CONCLUSION. Chronic adenoiditis and tonsillar hypertrophy can increase the incidence of malocclusion in children, as well as causing changes in length and shape of the upper jaw and mandible, resulting in maxillofacial deformities.
Endothelial progenitor cell (EPCs)-derived exosomal miR-30d-5p inhibits the inflammatory response of high glucose-impaired fibroblasts by affecting the M1/M2 polarization of macrophages
Authors: Xiong Wu , Tan Mei-xin , Chen Zi-lin , Liu Yu , Liu Yang , Zou Xiao-ling , Wang Xiao-qin , Yang Ya , Tan Pei , Zhang Xi
Published: October 2022

Background: Diabetes is a common chronic disease which has caused a great burden on families and society. The treatment of diabetes has always been a hotspot. This study aimed to explore the effect and mechanism of miR-30d-5pon inflammation of high glucose-impaired human keloid fibroblasts (HKF).

Methods: Differently-expressed miRNAs were predicted by bioinformatics methods. Exosomes were observed by transmission electron microscope. Exosome particle sizes were measured by NanoSight. Western Blot was used to detect the expression of CD81, CD63, CD9, and Calnexin. QRT-PCR was used to detect the expression of miR-30d-5p, IL-1β, TNF-α, VEGF, FGF21, NRF2, and HO-1. The levels of IL-1β, TNF-α, IL-6, IL-10, and TGF-β were determined by ELISA. Cell apoptosis and CD86, CD206 positive cells were detected by flow cytometry.

Results: Tori formula could promote the secretion of endothelial progenitor cell (EPCs) exosomes. EPCs exosomes and miR-30d-5p could stimulate the proliferation of HKF impaired by high glucose and the expression of IL-10 and TGF-β. MiR-30d-5p inhibited the proliferation of M1 macrophages and the expression of IL-1β and TNF-α. It could also promote the proliferation of M2 macrophages and the expression of CCL17 and CCL22. Moreover, miR-30d-5p stimulated the expression of VEGF, FGF21, NRF2, and HO-1, as well as suppressed the expression of IL-1β, TNF-α, and IL-6. MiR-30d-5p also restrained the apoptosis of impaired HKF. Conclusion: This study confirmed that miR-30d-5p could promote the M1/M2 polarization and inhibit the inflammatory response of impaired HKF, which provided a certain idea and direction for treating diabetes.
Correlations of cofilin1 and phosphorylation at Ser3 site with sensitivity of elderly patients with non-small cell lung cancer to radiotherapy
Authors: Lu Feijie , Zhong Chunrong , Dong Yongquan , Wang Mingming , Yang Qi
Published: October 2022

Background: To explore the correlations of cofilin1 (CFL1) and phosphorylation level of locus serine residue at position 3 (Ser3) with the sensitivity of elderly patients with non-small cell lung cancer (NSCLC) to radiotherapy.

Methods: A total of 102 eligible patients treated from June 2013 to April 2015 were selected. The cases of complete remission and partial remission were included into radiotherapy-sensitive group (n=55), while those of stable disease and progressive disease were enrolled into radiotherapy-resistant group (n=47). Before treatment, tissues were collected to detect the expressions of CFL1 and CFL1 (phospho S3) by immunohistochemistry. The survival time and rate were recorded during follow-up.

Results: Compared with the radiotherapy-sensitive group, the radiotherapy-resistant group had advanced tumor-node-metastasis (TNM) stage and higher lymph node metastasis rate (P=0.000, 0.000). Compared with the tissues with negative CFL1 expression, the tissues with positive CFL1 expression had advanced TNM stage and higher lymph node metastasis rate (P=0.013, 0.000). The positive expression rate of CFL1 in the radiotherapy-resistant group was higher than that of the radiotherapy-sensitive group, whereas the positive expression rate of CFL1 (phospho S3) in the former was lower (P=0.000, 0.000). Lymph node metastasis, high CFL1 expression, and low CFL1 (phospho S3) expression were independent predictors for resistance to radiotherapy (P=0.001, 0.006, 0.003). In the radiotherapy-sensitive group, the patients with negative CFL1 expression and positive CFL1 (phospho S3) expression had long progression-free survival and high 5-year survival rate (P=0.000, 0.000).

Conclusion: The sensitivity to radiotherapy of elderly NSCLC patients is correlated negatively with CFL1 and positively with phosphorylation at locus Ser3. CFL1 and phosphorylation at locus Ser3 are independent predictors for sensitivity to radiotherapy.
Protocol and Matters for Consideration for the Treatment of Polymerase Chain Reaction Contamination in Next-Generation Sequencing Laboratories
Authors: Wang Lin , Ma Chen , He Bin , Qiang Rong , Zhang Hongsu
Published: October 2022

Objective: The contamination of polymerase chain reaction (PCR) samples in molecular diagnostic laboratories can cause serious consequences. Internal quality control efforts are often inadequate, especially in clinical next-generation sequencing (NGS) laboratories.

Methods: In this study, we retrospectively investigated an incidence of PCR contamination and its decontamination process in a clinical laboratory. We performed a series of measures for decontamination. Taqman fluorescence quantification was carried out to determine the presence of contaminating DNA. SYBR-Green PCR was conducted to evaluate the effect of chlorine disinfectant on NGS library preparation.

Results: Through a series of elimination measures undertaken over 8 weeks, the decontamination process was verified as reliable. Almost no contamination was detected. Chlorine disinfectant should be forbidden in Illumina NGS laboratories because it may cause the failure of library preparation.

Conclusion: Our prevention and decontamination strategies could effectively eliminate PCR amplicons. Chlorine disinfectants should not be used in Illumina NGS laboratories.
INTEGRATED PARKS OF ECOLOGICAL RESTORATION – A SUSTAINABLE DEVELOPMENT TOOL FOR PUBLIC AUTHORITIES, BUSINESSES AND INVESTORS
Authors:   Bucharest University of Economic Studies, Romania, PREDA Elena , BARA Simona ,   Bucharest University of Economic Studies, Romania, POPESCU Gabriel ,   Bucharest University of Economic Studies, Romania
Published: October 2022

Environmental and climate change issues have begun to become points of interest for the financial services industry, due to both global and European policy trend - the Green Deal, the Climate Change Mitigation Treaty, the reduction of companies’ carbon emissions, etc. - as well as for the relevant scientific and regulatory authorities. The process of institutional construction of the new entities represented by the ecological restoration parks was born from the need to encourage the multi and interdisciplinary remediation and integrated monitoring works of some damaged natural areas. The purpose of this paper is to provide a new approach to ecological restoration activities, taking into account not only the technical aspects of restoration works, but also new ways of them integrating economically and socially. The paper is organized on following issues: the need to establish a general institutional framework for ecological restoration; specific technical requirements for establishing future complex ecological restoration parks; financing the ecological restoration parks; advantages of institutional recognition of ecological restoration parks. Ecological restoration parks can become a source for the design and jobs designing in the medium and long term, given the duration of restoration of bio components and / or of relationships affected and subject to ecological restoration.
OVERVIEW ON FACTORS WEAKENING THE RELATIVE COMPETITIVENESS OF FOOD VALUE CHAIN IN ROMANIA vs. EU
Authors:   Institute of Agricultural Economics – The Romanian Academy, RUSALI Mirela-Adriana
Published: October 2022

The present paper aims to provide a basis for policy decision by undertaking investigations on certain factors recently affecting Romania’s food value chain competitiveness. The research highlights structural imbalances caused by the larger share of the primary production against the sector of capitalization on agricultural products, changes concerning the value added in the food chain in Romania, comparing to EU-28, shown by i.e. the decrease of the value added in Romania’s food chain, caused by agriculture and food industry down trend - the outcome provides indications residing in value of production structure of the agri-food processing industry, where the value added achieved in food and beverages industry has been severely exceeded by the up trending production costs.
FOOD TRENDS IN THE FIRST HALF OF 2020
Authors:   Bucharest University of Economic Studies, Romania, TURCEA Vlad Constantin
Published: October 2022

The COVID-19 coronavirus outbreak has affected people around the world. In this short period of time, the critical situation became synonymous with medical, social and economic challenges. The results of several restrictions applied throughout the states resulted in major disruptions especially in working patterns, supply chains and food consumption. Uncertain times caused people actively change their usual habits especially diets. The present paper wants to track the trending food commodities of this already shaking half year of 2020, analyzing both global and local market trends, focusing on the FMCG sector, highlighting the opportunities and threats in order to make the short-term future lesser blurred in the food sector.
Risk-oriented approach as a research method for the effect of man-made underwater noise upon marine ecosystems
Authors:   Krylov State Research Centre, St. Petersburg, Russia, Malyarenko N.L.
Published: October 2022

Object and purpose of research. This paper discusses the effect of man-made underwater noise upon marine ecosystems. The purpose was to investigate the international practice of applying the risk-oriented approach to determination of environmental impact for man-made underwater noise in terms of marine ecosystems, as well as to discuss the introduction of risk management tools and conceptual models of ecosystem-based management of man-made underwater noise, including the Arctic areas. Subject matter and methods. This paper is based upon the methodical materials developed by KSRC, international risk management standards, as well as Russian and foreign publications in this field. The study relies on system analysis methods. Main results. The study analysed the results of international investigations regarding the assessment of man-made underwater noise effect upon marine ecosystems using the methodology of environmental risk management. It also discussed conceptual approaches to the assessment of marine noise pollution. As a case study, this paper discussed a regional environmental risk assessment in terms of shipping noise effect upon whales. The study concludes that risk-based and ecosystem-oriented approaches are possible and practicable to apply in man-made underwater noise management so as to preserve biodiversity and environmental status of Russian seas. Conclusion. International projects and programs rely on risk-based assessments in their approaches to the investigation of man-made underwater noise effect upon marine ecosystems. Russia needs its own scientific basis for man-made underwater noise management based on the methodology and practice of risk-oriented approach.
Measuring university performance in Tanzania: A comparative analysis of market orientation scales
Authors:   Department of Economics and Finance, Muslim University of Morogoro, Morogoro, Tanzania, Dau Ramadhani Kitwana , Yussuf Huda Ahmed ,   Department of Economics and Finance, Muslim University of Morogoro, Morogoro, Tanzania
Published: October 2022

This study makes a comparison between a well- established tool for measuring market orientation (MKTOR) with a new tool especially designed for measuring university performance, i.e., University MARKOR. Data were collected from 212 private and public universities across Tanzania and were an analyzed using AMOS 22. A response rate of 58.2% was achieved and considered adequate. The findings show that both scales demonstrated good model fit. Consistent with previous studies University MARKOR has demonstrated superior psychometric properties than MKTOR.Strong leadership is needed at universities in order to identify new sources of funding and reduce their dependence on traditional sources such as school fees, subventions and grants. A major contribution of this study is that it is the first ever study in Africa which is pan territorial involving both private and public universities that has tested the robustness of market orientation scales.
Dissipative Arithmetic
Authors:   Department of Computer Science University College London, Langdon William B.
Published: October 2022

Large arithmetic expressions are dissipative: they lose information and are robust to perturbations. Lack of conservation gives resilience to fluctuations. The limited precision of floating point and the mixture of linear and nonlinear operations make such functions anti-fragile and give a largely stable locally flat plateau a rich fitness landscape. This slows long-term evolution of complex programs, suggesting a need for depth-aware crossover and mutation operators in tree-based genetic programming. It also suggests that deeply nested computer program source code is error tolerant because disruptions tend to fail to propagate, and therefore the optimal placement of test oracles is as close to software defects as practical.
التحليل المكاني للحوادث المرورية في مدينة سامراء لعام 2020
Authors: Saleh Ahmed Omar Mohamed
Published: October 2022

منذ زمن بعيد أصبحت الحوادث المرورية والإصابات الناتجة عنها تشكل هاجسا مقلقا لجميع فئات المجتمع كونها متصلة بأحد الأنشطة اليومية المهمة التي لم يعد بالإمكان الاستغناء عنها إلا وهي استخدام المركبات في حركة النقل والتنقل، فعلى الرغم مما أتاحته المركبات للأفراد من مميزات كبيرة كاختصار الوقت وطي المسافات وتواصل الجماعات البشرية المتباعدة فيما بينها وتنظيم حياة الناس، فضلا عن حمايتهم من تقلبات المناخ وأحوال الطقس المختلفة ، ألا إن استخدامها في الفترة الأخيرة بات محفوفاً بالعديد من المخاطر ، وهذا استدعى القيام بدراسة هذه الظاهرة وبيان اسبابها وتكرار حدوثها وتحديد أهم النقاط أو الاماكن التي تحدث فيها الحوادث المرورية ومحاولة ايجاد الحلول الملائمة للحد من وقوع هذه الظاهرة ضمن الحدود الادارية لمدينة سامراء , فمن خلال الدراسة والتحليل تبين ان هناك تباين في نسبة وقوع الحوادث المرورية ونوعيتها من حيث الاصطدام والدهس والانقلاب وحجم الخسائر البشرية والمادية الناتجة عنها وذلك بحسب طبيعة الزخم السكاني و المروري  .
الأزمات الإقتصادية في عهد الخليفة المقتدر بالله العباسي (295 – 320 هـ/ 907 – 932م)
Authors: Muslah Hussein Khalid
Published: October 2022

يعد العامل الاقتصادي عصب الحياة قديما وحديثا، لذلك لا يمكن إغفاله وعدم البحث فيه تحت كل الظروف ، ومما دعاني الى اختيار هذا الموضوع جملة أسباب أهمها طول فترة حكم الخليفة المقتدر بالله التي وصلت الى ربع قرن، مع كثرة الأزمات الاقتصادية في عهده. وقد تناول البحث الأسباب التي أدت وساهمت في حدوث تلك الأزمات ، كما تم البحث في النتائج التي ترتبت على تلك الازمات والتي كان أهمها الاضطرابات والفتن والجوع وقد دفع ثمنها عامة الناس آنذاك. وكان للعوامل الطبيعية نصيبها من تلك الأزمات. وتم تقسيم البحث الى مجموعة نقاط وليس مباحث وذلك لتسهيل دراسته وليتسق وينتظم في منهاجه وأحداثه. كما تم الاستعانة بعدد من المصادر والمراجع والرسائل الجامعية ذُكرت في نهاية البحث.
اثر انموذج رحلة التدريس في تحصيل طلاب الصف الخامس العلمي في مادة التربية الاسلامية وتنمية تفكيرهم المستقبلي
Authors: Sahab Saadia M.
Published: October 2022

هدف البحث التعرف على اثر انموذج رحلة التدريس في تحصيل طلاب الصف الخامس العلمي في مادة ‎التربية الاسلامية وتنمية تفكيرهم المستقبلي.
 تم اختيار المنهج التجريبي ذو المجموعتين المتكافئة , طبق البحث في الفصل الدراسي الاول من العام الدراسي (۲۰۲۰-۲۰۲۱) م تكونت العينة من (60) طالبا بواقع (30) طالبا في كل من المجموعة التجريبية والضابطة .كوفئت المجموعتين بمتغيرات عدة واعدت الباحثة اغراضا سلوكية للمادة العلمية, وخططا تدريسية . وأعدت اداتين للبحث هما اختبارا تحصيليا تألف من(40) فقرة موضوعية ومقياسا للتفكير المستقبلي تكون من (40) فقرة بثلاثة بدائل وتم التحقق من صدقهما وخصائصهما السايكومترية كما تم أيجاد ثباتهما .بعد الانتهاء من تدريس المجموعتين وتطبيق الاختبارات البعدية تمت معالجة البيانات احصائيا وأظهرت نتائج البحث :
‎۱-وجود فرق ذو دلالة إحصائية بين متوسط درجات طلاب المجموعة التجريبية الذين درسوا وفقا لأنموذج رحلة التدريس ودرجـات طـلاب المجموعة الضابطة الذين درسوا وفقا للطريقة الاعتيادية في الاختبار التحصيلي ‎ومقياس التفكير المستقبلي لصالح متوسط المجموعة التجريبية.
 ۲-وجود فرق ذو دلالة إحصائية بين متوسطي درجات طلاب المجموعة التجريبية الذين درسوا وفقا لأنموذج رحلة التدريس قبل التجربة وبعدها في مقياس التفكير المستقبلي لصالح المتوسط البعدي .
‎وبناء على هذه النتائج وضعت الباحثة جملة من الاستنتاجات والتوصيات كما اقترحت أجراء دراسات مستقبلية .