bluuebunny/crossref_metadata_2025 huggingface dataset:
Dative Microvariation in African Varieties of Portuguese
Authors: Gonçalves Rita , Duarte Inês , Hagemeijer Tjerk
Published: June 2022

In this paper we compare dative ditransitive structures in nativized and nativizing urban varieties of Portuguese spoken in Angola, Mozambique, and São Tomé and Príncipe, using a corpus-based approach. It is shown that the expression of the Recipient exhibits considerable variation within and across these varieties, as well as at intraspeaker level. Despite the use of non-canonical patterns, namely prepositional structures with em and para and double object constructions, the canonical European Portuguese pattern with Case marker a is predominant in our data. Moreover, the pronominalized counterparts of these different realizations show much less variation and strong convergence toward dative clitic lhe(s). To account for the data, we propose a Larsonian VP-shell in which Recipients as extended DPs occur internally to a K(ase) projection whose functional head can be spelled out as a, em or para. Recipients in double object constructions, on the other hand, are treated as plain DPs which may pronominalize as dative clitics or, less commonly, as strong pronouns. Overall, our hypothesis weakens the role of language contact, which has often been assumed as a critical factor in the literature, but still allows for (individual) grammars that show evidence of being substrate-induced.
Methodological Features of the Development
of Specific Coordinating Abilities of Goalball Players
Authors: Gruzdev A. N. , Khlystov P. A. , Shpagin S. V. , Lerner V. L.
Published: June 2022

An attempt was made to determine the sports-specific coordination abilities necessary for goalball player for productive performance. The features of their manifestation were revealed taking into account the complete or partial visual deprivation of athletes, as well as
the features of physical and technical fitness in goalball. Recommendations are given on the selection of means and methods for developing the ability to react, rebuild, orient and differentiate the parameters of goalball players’ movements during the training process.
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Authors: not provided bill
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Making Blood Agar Plates v1
Authors: Sycuro Laura
Published: June 2022

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MORPHOMETRICS OF TIRASIANA FROM VENDIAN OF PODILLIA (UKRAINE)
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Mienasova А. , Popova L. ,   Schmalhausen Institute of Zoology NAS of Ukraine, Kyiv, Ukraine, Dzeverin І. ,   Schmalhausen Institute of Zoology NAS of Ukraine, Kyiv, Ukraine
Published: June 2022

Tirasiana Palij, 1976 is a genus of radially symmetric Vendobionts, which were preserved as a positive hyporelief of two superimposed discs. Tirasiana are found in the Vendian deposits of the Podolian Dnister area, the White Sea area and the Urals. For better understanding of the nature and lifestyle of Vendian biota, imprints of the Tirasiana were investigated by statistical methods. Sampling of 29 specimens of Tirasiana was studied. To test the hypothesis about the allometric growth of Tirasiana, two features were studied, the diameters of the outer and inner discs. As a result of the study, it has been established that the relationship between internal and external diameters of the imprints is almost ideally isometric, which means that there is no evidence for relation between Tirasiana and Cnidaria. The distribution patterns of these features were analyzed and the assumption about their normality was tested. Histograms of their distribution and empirical additional cumulative distribution functions were constructed. Based on the assumption of the constant growth of Tirasiana throughout onthogenesis and the proportionality of the linear size and individual age, the cumulative distribution functions may be considered as survival curves in the sampling of specimens of Tirasiana and may be analyzed by standard methods accepted in ecology. If we accept this assumption, then the survival curve of the first type is characteristic of the Tirasiana, which corresponds to the increase of probability of their death with the increase of individual age. The studied taphocenosis was formed as a result of accumulation of terrigenous material, which came from the nearby land that was not stabilized by vegetation. This terrigenous sediment buried benthic sublittoral communities regularly. The heterogeneity of the sampling of specimens can be explained by the presence of "survival stations", well-protected parts of the palaeobasin (overhanging rocks, baybar, etc.). As a result, in such places Tirasiana could attain much larger size.
REVIEW OF ELECTROMAGNETIC MONITORING STUDIES IN PREDICTING EARTHQUAKES: RECENT RESULTS AND NEW PERSPECTIVES
Authors:   Baku State University, Baku, Azerbaijan, Piriyev R.
Published: June 2022

In order to make comparisons and find new perspectives in terms of electromagnetic phenomena in earthquake prediction, ULF range was chosen. For comparison, tables consisting of the results of studies from previous years and the last 10 years have been compiled. In order to find new perspectives, the graphs were drawn and comparative analysis was carried out on the basis of these results. It was concluded that the ULF precursors can be found before earthquakes reaching up to 30km in depth, and it can be considered a promising effective range in detecting precursors of earthquakes. In addition, due to the connection between the epicenter distances and the depths of the earthquakes and their magnitudes, attempts to detect the precursors have been made so that the epicenter of the earthquakes is ±100km. The article also provides information about ULF networks and about researchers who had critical opinions on electromagnetic phenomena associated with earthquakes.
RESERVOIR PROPERTIES AND PROSPECTIVES OF LOWER PLIOCENE SEDIMENTS IN THE UMID AREA OF THE BAKU ARCHIPELAGO
Authors:   Azerbaijan State Oil and Industry University, Baku, Azerbaijan, Nasibova G. , Mukhtarova Kh. ,   Azerbaijan State Oil and Industry University, Baku, Azerbaijan, Narimanov R. ,   Azerbaijan State Oil and Industry University, Baku, Azerbaijan
Published: June 2022

The objective of this study is to investigate and analyze the reservoir properties of the Lower Pliocene sediments of the Baku Archipelago Umid area and its oil and gas potential. One of the latest studies in the Umid area was geological assessment of reservoir parameters for calculation of hydrocarbon reserves. The earlier obtained results made it possible to more reliably calculate hydrocarbon reserves and plan prospecting and exploration works in the right direction. Large gas condensate reserves were identified in 2009 in horizons V and VII of the Productive Series (PS). Thus, well 10 produced 1.2 million m3/day of gas and 150 tons of condensate from the depth interval of 6340-6356m. Considering that hydrocarbon fields of the South Caspian depression (SCD) are, as a rule, multilayered, this is a reason to predict presence of hydrocarbon accumulations in deeper strata as well. Variation patterns of reservoir properties, such as grain composition, carbonate content, porosity, permeability, density, propagation velocity of ultrasound waves in rocks were not comprehensively investigated in the previously conducted studies. The article studies impact of the structural and tectonic properties of the Umid uplift of the SCD Baku archipelago upon formation of a mud volcano on the southeastern periclinal subsidence. Taking into account impact of compressional stresses on the position of the fold vault and the crater of the mud volcano in connection with the syndepositional development of the uplift, a recommendation on the location of prospecting wells to deeper horizons is substantiated. Formation of reservoir properties of rocks is a function of tectonic stresses arising in them. Occurrence of secondary reservoir properties in rocks is highly probable in tectonically active zones. There is a stable inverse relationship between reservoir properties, carbonate and clay content, and a direct one - with the degree of grain sorting that make up the rocks. The issues considered in the article indicate a high probability of presence of hydrocarbon accumulations here in deeper horizons of the sedimentary section. In the future, based on our studies and geological and geophysical methods, it will be possible to thoroughly assess the prospects of deep-lying stratigraphic units of this area, and those identical to it.
METHOD FOR OIL AND GAS ESTIMATES OF EXPLORATION SITES VIA GEOLOGICAL, PARAMETRIC AND SATELLITE INFORMATION
Authors:   Scientific Centre for Aerospace Research of the Earth NAS of Ukraine, Kyiv, Ukraine, Popov M. , Тopolnytskyi М. ,   Scientific Centre for Aerospace Research of the Earth NAS of Ukraine, Kyiv, Ukraine, Titarenko O. ,   Scientific Centre for Aerospace Research of the Earth NAS of Ukraine, Kyiv, Ukraine, Stankevich S. ,   Scientific Centre for Aerospace Research of the Earth NAS of Ukraine, Kyiv, Ukraine
Published: June 2022

The article is devoted to the search and exploration of hydrocarbons deposits, which is a crucial and complicated geological task and requires the large bulk of initial data and significant intellectual efforts of geologists. In this regard, the urgent problem is to ease the working conditions of experts and improve the accuracy of forecasting the oil and gas potential of subsoil areas through the use of novel digital methods of heterogeneous data integration and interpretation. The paper proposes a new method to form predictive estimates of the oil and gas content of subsoil areas via combining geological, ground-based parametric, and satellite information. As the mathematical basis of the method, the means of Dempster-Shafer's theory of evidence are used, which makes it possible to combine data from different sources, proceed with incomplete and inaccurate data, etc. Most of the procedures that make up the body of the method are presented in the form of algorithms, which simplifies its technologization. The final information product of the proposed method is a map with the distribution of probabilistic estimates of oil and gas prospects of subsoil areas within a given study area. The developed method is implemented in software and tested at the Vostochno-Rogintsovskoye oil field. The test results indicated its fairly high efficiency.
A PREDICTIVE USER BEHAVIOUR ANALYTIC MODEL FOR INSIDER THREATS IN CYBERSPACE
Authors: Amuda Olarotimi Kabir , Akinyemi Bodunde Odunola , Sanni Mistura Laide , Aderounmu Ganiyu Adesola
Published: June 2022

Insider threat in cyberspace is a recurring problem since the user activities in a cyber network are often unpredictable. Most existing solutions are not flexible and adaptable to detect sudden change in user’s behaviour in streaming data, which led to a high false alarm rates and low detection rates. In this study, a model that is capable of adapting to the changing pattern in structured cyberspace data streams in order to detect malicious insider activities in cyberspace was proposed. The Computer Emergency Response Team (CERT) dataset was used as the data source in this study. Extracted features from the dataset were normalized using Min-Max normalization. Standard scaler techniques and mutual information gain technique were used to determine the best features for classification. A hybrid detection model was formulated using the synergism of Convolutional Neural Network (CNN) and Gated Recurrent Unit (GRU) models. Model simulation was performed using python programming language. Performance evaluation was carried out by assessing and comparing the performance of the proposed model with a selected existing model using accuracy, precision and sensitivity as performance metrics. The result of the simulation showed that the developed model has an increase of 1.48% of detection accuracy, 4.21% of precision and 1.25% sensitivity over the existing model. This indicated that the developed hybrid approach was able to learn from sequences of user actions in a time and frequency domain and improves the detection rate of insider threats in cyberspace.
ENERGY AWARE ROUTING FOR WIRELESS SENSOR NETWORKS
Authors: Monir Marvy Badr , Mohamed Amr Ayman
Published: June 2022

Wireless sensor networks are used in improving conditions in the practical field and real life which lead researchers and developers to further research it and work into improving this field. These networks consist of sensor nodes that can help acquire data and information about temperature and pressure dependent on the environment of the location which are sent from. After all that, we are bounded by a really important factor which can determine everything which is Energy. Since sensor nodes send data and information to web applications, they need an energy source to operate. Their main energy source is their batteries which offer limited source of energy. Hence, various protocols are introduced to help in many parameters of a wireless sensor network such as increasing lifetime and decreasing consumption of energy, in other words, increasing the Energy Efficiency (EF). In this paper, we evaluate consumption of average energy for various protocols used in this context after each complete logical round for these protocols, such as Energy Efficient Clustering Scheme and Stable Election Protocol. Finally, we used Matlab tool to generate results which indicate that the protocol used in this paper is efficient and reliable.
Automatic Building of a Powerful IDS for The Cloud Based on Deep Neural Network by Using a Novel Combination of Simulated Annealing Algorithm and Improved Self- Adaptive Genetic Algorithm
Authors: Chiba Zouhair , El Kasmi Alaoui Moulay Seddiq , Abghour Noreddine , Moussaid Khalid
Published: June 2022

Cloud computing (CC) is the fastest-growing data hosting and computational technology that stands today as a satisfactory answer to the problem of data storage and computing. Thereby, most organizations are now migratingtheir services into the cloud due to its appealing features and its tangible advantages. Nevertheless, providing privacy and security to protect cloud assets and resources still a very challenging issue. To address the aboveissues, we propose a smart approach to construct automatically an efficient and effective anomaly network IDS based on Deep Neural Network, by using a novel hybrid optimization framework “ISAGASAA”. ISAGASAA framework combines our new self-adaptive heuristic search algorithm called “Improved Self-Adaptive Genetic Algorithm” (ISAGA) and Simulated Annealing Algorithm (SAA). Our approach consists of using ISAGASAA with the aim of seeking the optimal or near optimal combination of most pertinent values of the parametersincluded in building of DNN based IDS or impacting its performance, which guarantee high detection rate, high accuracy and low false alarm rate. The experimental results turn out the capability of our IDS to uncover intrusionswith high detection accuracy and low false alarm rate, and demonstrate its superiority in comparison with stateof-the-art methods.
The Crisis of Han Classical Scholarship and Exegetical Trends in the Kingdom of Wei
Authors: Bonch-Osmolovskaya Olga A.
Published: June 2022

The paper focuses on Confucian exegetical thought during the transition from the late Han to Three Kingdoms period (late 2nd and 3rd Cent. AD). The political crisis, which resulted in collapse of the Eastern Han dynasty and led to the decentralization of power, accelerated some processes that had already begun in the field of Confucian exegetics during the Eastern Han period. As the first consequence, the school traditions of the Han Classical scholarship lost both unity and authority. The debates that broke out in the 3rd Cent. AD on the topic of correct or incorrect interpretation of the texts of Confucian Classics, together with the emergence of new versions of interpretations and criticism of previous commentators, are associated with bringing exegetics to the level of a fairly open discussion. All this contributed to the shift of exegetical research to the polemic stage, starting from the late Han and Three Kingdoms period, when Confucian scholars openly refuted each other, introduced new commentary types, compiled their commentaries in the form of a dialogue. The paper traces main trends of Confucian Classical scholarship in the Cao-Wei kingdom and examines main commentary works of this period.
Han Documents Preserved in the First Chapter of the Han Shu: Distribution Structure and Reflection of the Political Process
Authors: Bashkeev Victor V.
Published: June 2022

This article discusses four types of documents being preseved in the second part of the first chapter (1B) of the Han shu (The History of Han) [1], the main source for the history of the Western Han state (202 BC 8 AD). The Han shu 1B chapter covers the period from 202 to 195 BC. the reign of the first emperor of the new Liu dynasty, Liu Bang, better known as Gao-zu. The article examines the distribution structure, content and the role of documents preserved in the text of the Han shu 1B chapter and singled out by the author as independent structural elements of the chapter, along with chronicle reports, historical reports, historical narratives and dialogs in the reflection of the historical reality. These are documents of higher bureaucratic turnover of varying degrees of importance. The analysis of the dynamics of document distribution in the text of the Han shu chapter 1B allowed to establish the fact of increased activity of Emperor Liu Bang in the sphere of administration in the penultimate year of his reign at the very beginning of the transition from the forceful subjugation of political opponents to the peaceful administration of the power he was creating.
Phenotypes of lymphocytes in exudate in atopic dermatitis
Authors: Kibalina Irina V. , Tsybikov Namjil N. , Fefelova Elena V.
Published: June 2022

Aim. To determine subpopulations of lymphocytes in exudate in atopic dermatitis.
Material and methods. The study included 80 patients with atopic dermatitis according to predetermined inclusion and exclusion criteria, who were under dispensary supervision at the Regional Dermatovenerologic Dispensary (Chita) from 2018 to 2021. Two groups (adolescents and adults) and two subgroups (patients with limited and widespread lesions) were formed. Skin exudate sampling was carried out during the period of exacerbation of the disease. The control group consisted of 30 practically healthy volunteers undergoing a medical examination at the same dispensary, having primary health records and meeting the inclusion criteria for the study. Lymphocyte phenotypes were determined in skin exudate by flow cytofluorometry. Statistical analysis was performed using Microsoft Excel, IBM SPSS Statistics version 25.0, and the ShapiroWilk test, MannWhitney and Wilcoxon U-test, KruskalWallis nonparametric analysis of variance were used. The data were presented by median and interquartile intervals Me (25%; 75%). The critical indicator of the significance level of the differences was p 0.05.
Results. In the exudate of practically healthy volunteers, obtained by the skin window method, no subpopulations of lymphocytes were detected. In the skin exudate of adolescents with limited lesions, the content of lymphocytes was 149.00 (129.75; 157.75) cells/l, T-lymphocytes (CD3+CD19) 109.5 (96.25; 113.75) cells/l, among them 48.95% active, T-helpers 42.5 (39.25; 57.50) cells/l, natural killers (CD3+CD16+CD56+) 38.50 (36.25; 41.00) cells/l, however, with the widespread process, the level of lymphocytes increased by 11% (p1=0.002), T-helpers by 45%, natural killers by 27%, T-lymphocytes up to 125.00 (110.5;135.75) cells/l (p1=0.00001). These indicators in adults and the level of cytotoxic T-lymphocytes (CD3+CD8+) in adolescents and adults had no significant differences. The number of T-NK-killers (CD3+CD16+CD56+) in adolescents was higher with a widespread process 23.00 (11.75; 29.75) cells/l (p1=0.0001), in adults with a limited process 18.00 (10.25; 20.75) cells/l (p2=0.0001). The number of NKCD8+ (CD3CD16+CD56+CD8+) in adolescents with limited dermatosis was 22.50 (18.25; 26.00) cells/l, with widespread dermatosis 1.6 times more (p1=0.0001), in adults with a limited process 29.50 (25.25; 33.75) cells/l, with widespread 27% less (p1=0.0001).
Conclusion. In the skin exudate in atopic dermatitis, cytotoxic T-lymphocytes, T-NK-killers, natural killers, CD8-positive NK-killers are detected.
Analysis of the antibacterial drugs use and evaluation of the caesarean section outcomes in the ­regional perinatal center in two time periods with a 10-year interval
Authors: Tashtanbekova Cholpon Cholpon , Evstratov Aleksey A. , Aleksandrova El'vira G. , Chuenkova Elena A. , Ziganshina Liliya E.
Published: June 2022

Background. Infectious inflammatory complications that occur in women after caesarean section may affect the length of hospital stay. Timely drug therapy plays a major role in preventing the development of complications in the postoperative period.
Aim. To conduct a comparative pharmacoepidemiological analysis of antibiotics use and evaluate the surgery outcomes (on the part of the puerperal and the newborn) in women delivered by caesarean section.
Material and methods. A retrospective analysis of 1025 birth histories of women after planned and emergency caesarean section with a detailed assessment of the antibiotics use in two time periods with a 10-year interval: in 20072009 (first period, n=523) and in 20162017 (second period, n=502) was carried out. The operation outcomes, the length of hospital stay, the duration of antibiotics use were studied. The significance of differences in relative indicators was assessed by Pearson (2).
Results. The frequency of prescribing antibiotics in monotherapy for planned and emergency cesarean section in both time periods did not differ (p=0.858; p=0.726). There were more cases of using two antibiotics at the same time in the first period, both for planned (88 cases, 35.5%) and for emergency surgery (93 cases, 34%; p=0.001). Combinations of three antibiotics were used more frequently in the first period than in the second. The increase in body temperature after surgery (37.5 C) was statistically indistinguishable in two periods. The duration of hospital stay with primary antibiotic therapy in the first period was 6 bed-days, with primary antibiotic prophylaxis in the second period 4 bed-days. Exacerbation of urinary tract infections during emergency and planned caesarean section was diagnosed 4 and 5 times more often in the first period than in the second. Outcome on the part of the newborn an Apgar score of less than 7 points was more common with emergency intervention in the second period (10%) than in the first (3.5%; p=0.003).
Conclusion. In the first studied time period (20072009), with combined antibiotic therapy after caesarean section, a longer stay of women in the hospital, a higher frequency of urinary tract exacerbations in puerperas, and a better assessment of the condition of newborns according to the Apgar score were registered, compared with these indicators in the second time period (in 20162017), when antibiotic prophylaxis was predominantly used.
The role of mitochondrial DNA in the pathogenesis of cardiovascular diseases
Authors: Kireeva Victoria V. , Lepekhova Svetlana A. , Inozemcev Pavel O. , Usoltsev Yuri K. , Trofimova Elena A.
Published: June 2022

Diseases of the cardiovascular system keeps the lead among the main causes of invalidity, disability and mortality ofthe population. There is a steady increase in cardiovascular diseases, that is why the identification of new markers, that would allow calculating the risks of complications and associated pathological conditions, is one of the most important tasks of modern fundamental and applied medicine. The paper presents current information on the relationship between the qualitative and quantitative characteristics of mitochondrial DNA with the risk of organ failure. The reasons for the body's immune response to the mitochondrial DNA presence outside the cell are considered. The question of mitochondrial DNAs role in the pathogenesis of cardiovascular pathology and inflammatory processes is highlighted. Contradictory information about the change in the amount of freely circulating mitochondrial DNA during the development of organ failure was revealed. However, all authors agree that the number of mitochondrial DNA copies indicates disorders associated with the provision of vital functions of cells, organs and tissues. The study shows that the level of freely circulating mitochondrial DNA in blood plasma, which is currently used to predict the development of complications and mortality in a number of different diseases, is a promising nonspecific marker of cytolytic processes. A comprehensive study of cytological, biochemical and molecular biological indicators at various (especially at early) stages of organ failure development, as well as during the cardiovascular diseases establishment, will provide new important information about the cellular mechanisms of disease pathogenesis and will form the basis for the development of early diagnostic markers and new therapeutic schemes.
Modern capabilities of the computed tomography in orbital traumatic injuries diagnosis
Authors: Davydov Dmitry V. , Serova Natalya S. , Pavlova Olga Yu.
Published: June 2022

BACKGROUND: Nowadays the problem of orbital trauma remains extremely relevant. Combined damage of several anatomical structures, globe injury, various clinical manifestations, the necessity of optimal surgical treatment require high-quality, timely diagnostics. Considering the current development of diagnostic equipment, postprocessing of CT data acquires the key role in order to obtain objective diagnostic information in patients with orbital trauma.
AIM: Evaluation of the effectiveness of the developed methods for CT data assessing in patients with orbital trauma.
MATERIALS AND METHODS: From 2016 to 2021 a total of 107 patients (100%) with orbital injuries were examined in Sechenov University clinics. All patients were distributed depending on the injury occurrence time: 50 patients (47%) in acute and subacute periods, 30 patients (28%) in the period of formation of post-traumatic deformities, 27 patients (25%) in the period of formed post-traumatic deformities. All patients (n = 107; 100%) underwent CT data analysis according to the developed protocol: analysis of bone and soft tissue trauma using a specialized algorithm, assessment of orbital volumes, evaluation of defects in the inferior orbital wall, examination of the globe position and of changes in the density of the orbital soft tissues.
RESULTS: In the preoperative period the developed algorithm for orbital volumes measuring additionally revealed a post-traumatic increase in orbital volume in 21 patients (19%). The technique for the globe position assessing additionally revealed the risk of enophthalmos in 9 patients (8.1%), and in 1 case (0.9%) the suspicion of globe displacement was not confirmed. The defects of the inferior orbital wall were classified into small (n = 18; 17%), medium (n = 31; 29%) and large/total (n = 38; 35% and n = 20; 19%, respectively). In 88 patients (82%), the ratio of the defect to the entire inferior orbital wall was more than 6.65%, in 19 patients (18%) less than 6.65%. Changes in the density of the orbital soft tissues were as follows: soft tissue edema n = 60 (56%), soft tissue atrophy n = 28 (27%), hematoma of the orbital soft tissues n = 10 (9%), density was not changed n = 9 (8%). In the postoperative period, the developed methods for CT data processing revealed incomplete restoration of the orbital volume in 31 cases (29%), incomplete coverage of the inferior orbital wall defect in 38 cases (35%), globe displacement in 14 cases (13%), which was not determined by the standard CT data assessment without the specialized technique. In 7 cases (6%), a suspicion of an increase in the orbital volume was not confirmed by the developed methodology.
CONCLUSION: The developed methods for measuring orbit volumes, assessing defects in the lower orbital wall, the globe position, and the condition of the orbital soft tissues provide statistically reliable additional diagnostic information about the patients condition and personalized approach for preoperative planning for each patient.
Prevalence and effect of misinformation on Twitter during the COVID-19 pandemic: A mixed-methods social media analysis
Authors: Jigish Khamar , Miranda Wu , Sharleen Maduranayagam , Thanansayan Dhivagaran , Ayushka Tiwary , Chaitali Parikh , Rebecca H. Correia
Published: June 2022

Throughout the COVID-19 pandemic, there has been an upward trend of medical misinformation circulating on social media. With the large reach of platforms like Twitter, misinformation can shape the opinions of masses on public health topics and behaviors. This study aims to assess the prevalence of misinformation on Twitter and its impact on the public through a concurrent mixed-methods design. In the quantitative component, we investigated the prevalence of misinformation on Twitter related to COVID-19 transmission, alternative treatments, and vaccines. Twitter shares for the most popular articles were collected at four time periods and misinformation was analyzed for temporal and topical changes. The qualitative component assessed the impact of misinformation by analyzing perspectives towards vaccine acceptance, mask adherence, and lockdown compliance on Twitter. Twitter articles regarding alternative COVID-19 treatments had the most misinformation (47.5%), followed by transmission (20.0%) and vaccines (8.8%). The prevalence of misinformation decreased over time for both alternative treatments and transmission. Conversely, vaccines displayed an increase in misinformation over time. Vaccine acceptance and mask adherence had considerable support; however, some individuals questioned the effectiveness of these measures. Lockdown compliance had mixed support as some supported the enhanced measures while others displayed frustration. Individuals showcased varying opinions on Twitter regarding their willingness to obey public health regulations. Overall, there was a high prevalence of misinformation regarding COVID-19 transmission, alternative treatments, and vaccines during the pandemic.
Comparative analysis of NX-2127 and ibrutinib in treating B-cell malignancies
Authors: Subin Jeon
Published: June 2022

Oncology is an ever-changing field of medicine with the constant development of innovative treatments. Small-molecule drugs have entered the spotlight in the past few decades for their efficacy, selectivity, and ability to target intracellular proteins. Small-molecule inhibitors (SMIs) are small-molecule drugs that inhibit proteins involved in tumour growth [1,2]. Proteolysis targeting chimeras (PROTACs) are heterobifunctional molecules that degrade proteins involved in tumour growth [3,4]. Both treatments have revolutionized the field of oncology as they have proven to be more beneficial than traditional treatments.
Effective Optimization of Billboard Ads Based on CDR Data Leverage
Authors: Semassel Imed Eddine , Ben Yahia Sadok
Published: June 2022

Call Detail Records (CDRs) provide metadata about phone calls and text message usage. Many studies have shown these CDR data to provide gainful information on people's mobility patterns and relationships with fine-grained aspects, both temporal and spatial elements. This information allows tracking population levels in each country region, individual movements, seasonal locations, population changes, and migration. This paper introduces a method for analyzing and exploiting CDR data to recommend billboard ads. We usher by clustering the locations based on the recorded activities' pattern regarding users' mobility. The key idea is to rate sites by performing a thorough cluster analysis over the achieved data, having no prior ground-truth information, to assess and optimize the ads' placements and timing for more efficiency at the billboards.
Paraneoplastic Severe Sensorimotor Axonal Polyneuropathy in Pancreatic Neuroendocrine Carcinoma: A Case Report and Review Of The Literature
Authors: AKBAŞ Türkay , KANTARCIOĞLU Sinem Coşkun , TORUN Serkan , ÖZTÜRK Ayhan , EŞBAH Onur , ÖNBAŞ Ömer
Published: June 2022

Objective: Paraneoplastic neurological syndromes (PNSs) are a diverse group of neurological disorders affecting any part of the nervous system before or during cancer. Case: A 78-year-old patient had pain and burning sensation first in the upper extremity 3 years ago, and then, muscle weakness was added a short time later. The same symptoms developed in the lower extremities 1 year ago. He was admitted to the intensive care unit due to pneumonia and was conscious but quadriplegic with a modified Rankin score of 5. Abdominal computed tomography showed mass lesions in the liver and pancreas. The biopsies demonstrated pancreatic small cell neuroendocrine carcinoma. Electrophysiological studies disclosed severe sensorimotor axonal polyneuropathy. Since other polyneuropathy causes were excluded, the diagnosis was paraneoplastic sensorimotor axonal polyneuropathy. Palliative care was considered because the patient had a poor functional state. Conclusion: Early cancer diagnosis is paramount in patients with PNSs to have appropriate therapy.
A Benchmark Similarity Measures for Fermatean Fuzzy Sets
Authors: Khan Faiz Muhammad , Khan Imran , Ahmad Waqas
Published: June 2022

In this paper, we utilized triangular conorms (S-norm). The essence of using S-norm is that the similarity order does not change using different norms. In fact, we are investigating for a new conception for calculating the similarity of two Fermatean fuzzy sets. For this purpose, utilizing an S-norm, we first present a formula for calculating the similarity of two Fermatean fuzzy values, so that they are truthful in similarity properties. Following that, we generalize a formula for calculating the similarity of the two Fermatean fuzzy sets which prove truthful in similarity conditions. Finally, various numerical examples have been presented to elaborate this method.
Perú 1990-2020: Heterogeneidad estructural y regímenes económicos regionales ¿Persiste la desconexión entre la economía, la demografía y la geografía?
Authors: Jiménez Félix , Arroyo Marco
Published: June 2022

En este trabajo se analiza si en el periodo 1990-2020 —que incluye quince años de alto crecimiento económico impulsado por la inversión extranjera en la minería—, se registró un proceso de convergencia del producto per cápita de las veinticuatro regiones del país. En otras palabras, se busca responder si en un contexto caracterizado por la concentración espacial de la producción y de liderazgo en el crecimiento económico de la producción minera, se acentuaron o se atenuaron las disparidades existentes entre las regiones del país; si crecieron más rápido las regiones pobres que las regiones ricas; o, si hay clubes o regímenes económicos que convergen a su propio estado estacionario, confirmando así la fragmentación del país. El análisis se realiza utilizando, en primer lugar, la técnica de análisis exploratorio de datos espaciales (ESDA, por sus siglas en inglés), para identificar tanto a la dependencia como a la heterogeneidad espacial en los productos per cápita de las regiones del país; y, en segundo lugar, la técnica de datos de panel y el spatial switching regression approach, a las que se les introduce la interacción espacial tomando en cuenta algunas características propias de las regiones.
Estrategias políticas de un familiar de la Inquisición en Buenos Aires. El caso de Juan Ignacio de Ezcurra (1784-1806)
Authors: Nasif Samir
Published: June 2022

El artículo indaga en un conflicto suscitado en el Cabildo de Buenos Aires a partir de la elección anual de oficios concejiles llevada a cabo en enero de 1804. La inmediata renuncia de uno de los alcaldes electos inició una controvertida disputa, que involucró diversas instancias de gobierno y que tuvo resonancias en la Corte de Madrid. A partir de documentos de variada procedencia, y recuperando los aportes metodológicos de la nueva historia política, la perspectiva jurisdiccionalista del poder político y los estudios sobre la Inquisición, este análisis se centra en las apelaciones y uso estratégico de las competencias políticas, así como en las yuxtaposiciones de oficios y privilegios en familiares de la Inquisición. El trabajo inscribe esta contienda en la dinámica de confrontación entre elencos de élite local, donde cobraban relevancia los vínculos de los capitulares y la procuración en la Corte. Además, el enfoque adoptado contempla el funcionamiento polisinodial de la monarquía, y no pierde de vista el contexto global donde ciertos privilegios —especialmente ligados al fuero inquisitorial— estaban siendo seriamente cuestionados.
Patronazgo en la corte virreinal novohispana: los criados, allegados y paniaguados del marqués de Guadalcázar (1612-1621)
Authors: Ayala Tafoya Eduardo
Published: June 2022

A través del estudio de conceptos de la cultura política de la Monarquía hispánica de los siglos XVI y XVII y de documentación inédita encontrada en el Archivo General de Indias, el presente artículo pretende analizar las modalidades, rasgos y límites del ejercicio del patronazgo del marqués de Guadalcázar durante su gestión novohispana (1612-1621). Así, se perfilan las redes clientelares del virrey al identificar a los integrantes de su séquito, el rol que algunos de ellos desempeñaron como agentes de los intereses personales de su patrón y la trayectoria de sus carreras propias en las Indias. Además, se trata de afirmar que la liberalidad del virrey no siempre pasó por alto a los beneméritos indianos, que benefició con distintas mercedes.
Sobre el discurso de la historia. Por una episteme del saber histórico
Authors: Sevillano Francisco
Published: June 2022

Este artículo revisa el estado del debate teórico sobre el discurso en el trabajo histórico. En la primera parte del estudio, se define la noción de discurso, sobre todo de acuerdo con el llamado «giro lingüístico» desde la década de los sesenta. Particularmente, se exponen los rasgos principales de este enfoque en relación con la disciplina de la historia de acuerdo con los presupuestos narrativistas y antirrealistas de la «nueva filosofía de la historia» y su reformulación por el «giro experiencial». Estos presupuestos son refutados en la segunda parte del artículo, argumentándose acerca del valor cognitivo de la historia ya desde sus orígenes clásicos.
Eugenio Mendoza: un líder de la industrialización del siglo XX en Venezuela
Authors: Valero Julio Edgar
Published: June 2022

El artículo examina la génesis y afianzamiento de Empresas Mendoza, el más importante consorcio industrial del siglo XX venezolano. El conjunto de empresas se consolidó con el liderazgo de Eugenio Mendoza y contó con apoyo estatal en medio de los auges y depresiones de una economía ligada a la renta petrolera. Se analiza el proceso en que después de un sostenido crecimiento económico, se produjo un debilitamiento y crisis en la cultura del trabajo y los mecanismos de disciplina de la fuerza laboral que habían sido efectivos inicialmente, así como varias problemáticas que llevaron a la extinción de este afamado grupo industrial.
Digitalization in education
Authors: Arisoy Burcu
Published: June 2022

This study aims to contribute to the literature on digitalization in education. In the study, a semi-structured interview form is used. The experts working in the educational field in private institutions were interviewed for this study. The study examines the effects of digitalization in education; although there are no specific studies for education departments in the private sector in the literature, it has been seen that the effects of digitalization are similar. The study also shows different factors such as the people's fears about digitalization in education, lack of authentic educational materials, its ineffectiveness compared to face-to-face education, and the scarcity of digital literacy.With digitalization in education, arranging educational content using technological opportunities, creating educational materials combined with virtual reality, and applying gamification in education becomes important in terms of the effectiveness of education.
 
Keywords ; Digitization, Education, HRM, HRM practices, Working life.