bluuebunny/crossref_metadata_2025 huggingface dataset:
GPS/Galileo/BDS-2/BDS-3 full-frequency uncombined precise point positioning with fast ambiguity resolution and single-epoch ambiguity resolution on a global scale
Authors: Qu Lizhong , Wang Luping , Wang Haoyu , Du Yiwei , Jiang Wei
Published: August 2022

For global fast and reliable precise point positioning (PPP), two groups of common uncombined PPP ambiguity resolution (AR) modes, fast and single-epoch, were implemented with the full-frequency signals of the GPS, Galileo, BDS-2 and BDS-3 constellations. A series of wide-lane (WL) uncalibrated phased hardware delay biases (UPDs) and narrow-lane (NL) UPDs of the GNSS MEO satellites were generated and transformed to full-frequency UPDs using 15 days of data in 2022 from 104 global stations. The performance of the full-frequency (FF) float, WL AR (WAR), and cascaded WL and NL AR (CAR) PPPs were investigated by comparing with the dual-frequency (DF), triple-frequency (TF) and quad-frequency (QF) solutions in two groups of positioning experiments using another 40 global stations. Results illustrated that the FF CAR PPP performed the best. In the fast AR PPP experiment, the percentages of convergence time within 2 min, 5 min and 10 min of the FF CAR PPP reached 20.3%, 68.7% and 98.6%, respectively. An average convergence time of 4.3 min was achieved. The average RMSs of the positioning errors in the east, north and up components during the initial 10 min were 0.04 m, 0.04 m and 0.18 m, respectively. In the single-epoch AR PPP experiment, the RMSs of the positioning errors in the three components of the FF CAR PPP were 0.07 m, 0.08 m and 0.28 m, respectively. The percentages of the positioning errors in the horizontal direction within 0.1 m, 0.3 m and 0.5 m reached 89.0%, 96.0% and 99.1%, respectively.
Exploring the structural basis of a subtype selective inhibitor for Aurora kinase B over Aurora kinase A by molecular dynamics simulations
Authors: Zhao Dong , Kovacs Antal H. , Campbell Michael , Floriano Wely , Hou Jinqiang
Published: August 2022

As promising therapeutic targets for several types of cancers, Aurora kinases A and B share remarkably high sequence and structure similarity, which render the design of subtype selective small-molecule inhibitors challenging. Since Aurora A acts as both an oncogene and a haploinsufficient tumor suppressor, inhibiting Aurora B with highly selective inhibitors represents a less toxic anti-cancer strategy. However, the molecular mechanism governing the ligand selectivity for Aurora A over B reminds elusive. In this study, an experimentally validated ligand, Barasertib which displays 1000-fold selectivity for Aurora B over A was used as a template molecule, and the selectivity mechanism was investigated by molecular dynamics simulation and binding free energy analyses. The computed binding free energies are consistent with the experimental bioactivity of Barasertib. The major residues that contribute to ligand binding were also identified. The hinge residue Arg159, only found in Aurora B was found to contribute significantly to the binding of Aurora B, while no such binding was found in Aurora A. A highly unfavorable polar interaction with Glu181 in Aurora A hinders the ligands binding ability. These 2 interactions play a key role in the observed selectivity of Barasertib for Aurora B over A. Interestingly, the binding of partner proteins forces the aC helix and the beta sheets in the N-lobe to move inward towards the ATP binding pocket, leading to a smaller hydrophobic back pocket and unfavorable binding. Taken together, our results show how differential behavior of the ligand arises from a complex interplay of small but relevant structural differences upon binding to different kinase subtypes. The insights gained into the structural determinants of subtype selectivity will facilitate the further development of highly selective and potent inhibitors as drug candidates for cancer therapy.
Lower Geriatric Nutritional Risk Index Are Associated with A Higher Incidence Of Osteoporosis In Northern China Type 2 Diabetes
Authors: Ji Yuan yuan , Geng Nan , niu ying chun , Zhao Hang , fei wen jie , Chen Shu chun , Ren Lu ping
Published: August 2022

Background Osteoporosis (OP) is very common in the elderly population and can lead to fractures and disability. Malnutrition is associated with osteoporosis. The Geriatric Nutrition Risk Index (GNRI) is used to assess the risk of malnutrition and complications associated with nutritional status in older patients and is an important predictor of many diseases. Therefore, we investigated the relationship between GNRI and osteoporosis in patients with type 2 diabetes to help us prevent and detect osteoporosis in time. Methods Retrospective study of 610 elderly patients with type 2 diabetes. Collection of general and laboratory data on the patient, together with measurement of bone mineral density (BMD). The GNRI was calculated based on ideal body weight and serum albumin (ABL) levels. Correlation analysis was applied to determine the relationship between GNRI and BMD and bone metabolism indexes. The predictive value of GNRI for the development of osteoporosis was analyzed by logistic regression analysis and creating a Receiver Operating Characteristic Curve (ROC), calculating the area under the cure (AUC).Results All patients divided into the no nutritional risk group and the nutritional risk group. Compared with the non-nutritional risk group, the nutritional risk group had longer diabetes course, older age, higher HbA1c and higher prevalence of osteoporosis; lower BMI, ABL, FCP, TG, Ca, 25 (OH) D, PTH and lower femoral neck BMD (P<0.05). Classified in ascending order of GNRI quartiles (Q1-Q4), lower GNRI among type 2 diabetic patients are associated with a higher Incidence of osteoporosis. All patients were grouped with non-osteoporosis group and osteoporosis group. Patients in the non-osteoporotic group had higher GNRI values compared to the osteoporotic group(P<0.05). Correlation analysis revealed that GNRI was positively correlated with lumbar BMD, femoral neck BMD and total hip BMD (P<0.05). After adjusting confounding factors, Spearman's correlation analysis was concluded that GNRI was positively correlated with Ca, 25(OH)D, PTH and negatively correlated with ALP and PINP. Regression analysis yields, GNRI was significantly associated with osteoporosis. ROC curve analysis was performed with GNRI as the test variable and the presence of osteoporosis as the status variable. The analysis yielded an area under the curve for GNRI of 0.695 and was statistically significant (P< 0.05), with an optimal GNRI threshold of 99.56 for predicting osteoporosis.Conclusions: Lower Geriatric Nutritional Risk Index among type 2 diabetic patients in northern China are associated with a higher Incidence of osteoporosis.
Teaching ST Concepts during a Pandemic: Modes for Engaging Learners
Authors:   National University of Singapore, RC4, 6 College Avenue East #17-11 RC4 NUS Singapore, 138614 Singapore, Tan Lynette , Balakrishnan Naviyn ,   National University of Singapore, RC4, 6 College Avenue East #17-11 RC4 NUS Singapore, 138614 Singapore, Varma Navarun ,   National University of Singapore, RC4, 6 College Avenue East #17-11 RC4 NUS Singapore, 138614 Singapore
Published: August 2022

Amongst the pressing concerns in the thick of the current global pandemic, particularly in the context of residential colleges within higher education, is that of our ability as educators to create a sense of community amongst our students, as well as to effectively facilitate learning in the online environment. A faculty at a public university in Singapore strategised to meet these challenges of teaching in a pandemic on two fronts – creating a level of online and hybrid classroom that would integrate as much of the face-to-face (f2f) experience for undergraduate residents as possible to retain a sense of community, as well as using asynchronous material to support students in their learning. To encourage student engagement, education technologies such as gamification are also utilised. This article considers the employment and impact of those strategies in classrooms where ST modules are taught: “Committed to Changing Our World: The Systems Pioneers” (n = 24), “Thinking in Systems: Disaster Resilience” (n = 48) and “Thinking in Systems: Diseases and Healthcare” (n = 32) leading to a total number of 104 students, mostly in their first and second years and from various disciplines, invited to participate in the study. This article shows pedagogical examples of how we as educators can innovate by using available online tools, while embracing the principles of good teaching to best support our students in their learning.
When in Doubt, Map it Out: Teachers’ Digital Storytelling Researched through Documentation
Authors: Lemieux Amélie , Mason Stephanie
Published: August 2022

This article considers how documentation enriches literacies learning in higher education, specifically in a graduate course designed for language teachers. Building on a one-year research study with graduate students at a university in the Atlantic region of Canada, the authors demonstrate how participant-generated documentation, including cartography, presents relational understandings impacting literacies. Specifically, the authors look at a case study of two teachers enrolled in a graduate literacy course who crafted and designed digital stories using Scratch and used multimodal dimensions from music to animation and movement. Teachers’ documentation challenges the idea that making is solely a question of doing, and considers instead long-lasting processes that influence teacher practice and development.
Investigating Characteristics of Learning Environments During the COVID-19 Pandemic: A Systematic Review
Authors: Al-Ansi Abdullah
Published: August 2022

Dramatic change in learning environments during the COVID-19 pandemic highlighted the significance of virtual learning and led to more interactive learning environments. Quick adoption of online and social interactive learning in many universities around the world raised challenges and emphasized the importance of investigating different learning environments. This paper investigates the accelerated transition in education from traditional learning environments through online learning environments to social innovative learning environments, and the latest trends of this change. The stages of transition were divided into three parts: before, during, and after the COVID-19 pandemic, which was the reason for this accelerated change. Features and characteristics of each stage of transition were analyzed and discussed, based on the following factors: edu-space and classrooms, the learning and teaching process, curricular choices, information and communication technology applications, students’ and educators’ perceptions, edu-approaches, and knowledge transformation. A systematic review approach was used to investigate learning environments based on the literature reviews of previous publications. Analysis of these features revealed the main characteristics and differences in each stage. New trends in online learning environments and social innovative learning environments were identified including cloud platforms, massive open online courses, digital learning management systems, open educational resources, open educational practices, m-learning, and social network applications. Finally, this study makes two recommendations: 1) the adoption of online learning environments and social innovative learning environment applications to continue the e-learning process during the pandemic, and 2) the enhanced usage of online learning environments and social innovative learning environment applications in the future by educational institutions and governments.
Learning, Technology, and Technique
Authors: Dron Jon
Published: August 2022

To be human is to be a user, a creator, a participant, and a co-participant in a richly entangled tapestry of technologies – from computers to pedagogical methods - that make us who we are as much as our genes. The uses we make of technologies are themselves, nearly always, also technologies, techniques we add to the entangled mix to create new assemblies. The technology of greatest interest is thus not any of the technologies that form that assembly, but the assembly itself. Designated teachers are never alone in creating the assembly that teaches. The technology of learning almost always involves the co-participation of countless others, notably learners themselves but also the creators of systems, artifacts, tools, and environments with and in which it occurs. Using these foundations, this paper presents a framework for understanding the technological nature of learning and teaching, through which it is possible to explain and predict a wide range of phenomena, from the value of one-to-one tutorials, to the inadequacy of learning style theories as a basis for teaching, and to see education not as a machine made of methods, tools, and systems but as a complex, creative, emergent collective unfolding that both makes us, and is made of us.
Colouring the Higgs boson
Authors: Buckley Andy , Callea Giuseppe , Larkowski Andrew J. , Marzani Simone
Published: August 2022

The jet colour ring is a novel colour tagger observable designed to separate the decay of a colour-singlet into two jets from a two-jet background in a different colour configuration. Simulation studies in the case of the production of a boosted Higgs boson decaying in two b-quarks and an associate electroweak boson, showed notable discriminator powers when comparing the jet colour ring performances with other observables. These results are opening a wide scenario for further studies.
BFKL phenomenology: resummation of high-energy logs in inclusive processes
Authors: Celiberto Francesco Giovanni , Fucilla Michael , Ivanov Dmitry Yu. , Mohammed Mohammed Maher Abdelrahim , Papa Alessandro
Published: August 2022

We present recent phenomenological studies, tailored on kinematic configurations typical of current and forthcoming analyses at the LHC, for two novel probe channels of the BFKL resummation of energy logarithms. Particular attention is drawn to the behavior of distributions differential in azimuthal angle and rapidity, where significant high-energy effects are expected.
Light meson decays at BESIII
Authors: Kang Xiao Lin
Published: August 2022

The world’s largest sample of J/\psiJ/ψ
events accumulated at the BESIII detector offers a unique opportunity to
investigate \etaη
and \eta^\primeη′
physics via two body J/\psiJ/ψ
radiative or hadronic decays. In recent years the BESIII experiment has
made significant progresses in \eta/\eta^\primeη/η′
decays. A selection of recent highlights in light meson spectroscopy at
BESIII are reviewed in this report, including the observation of
\eta^\prime\rightarrow\pi^+\pi^-\mu^+\mu^-η′→π+π−μ+μ−,
the study of \eta^\prime\rightarrow\pi^+\pi^-e^+e^-η′→π+π−e+e−,
and search for CPCP-violation
in this decay, search for the rare decays of
\eta^\prime\rightarrow4\pi^0η′→4π0
and \eta^\prime\rightarrow\gamma\gamma\etaη′→γγη,
as well as the precision measurement of the branching fraction of
\eta^\primeη′
decays.
Determination of $α_{S}$ beyond $NNLO$ using the event shape averages
Authors: Kardos Adam , Somogyi Gábor , Verbytskyi Andrii
Published: August 2022

In this proceedings we discuss a prescription to extract the QCD
strong coupling constant at N^{3}LON3LO
precision in perturbative QCD using a combination of
{{O}}(\alpha_{S}^{3})O(αS3)
calculations in pQCD and estimations of the
{{O}}(\alpha_{S}^{4})O(αS4)
corrections from the data. The method is applied to a set of event shape
averages measured in experiments at the LEP, PETRA, PEP and TRISTAN
colliders. In our analysis we account for hadronization effects with
models from modern Monte Carlo event generators and analytic
hadronization models. We conclude that the precision of the
\alpha_{S}αS
extraction cannot be improved significantly only with pQCD predictions
of higher orders, and further progress in these studies requires a
significant advances in the studies and modeling of hadronization
process.
Recent results on hyperon pair production and nucleon time-like form factors at BESIII
Authors: Mangoni Alessio
Published: August 2022

The BESIII experiment, based on the BEPCII collider at IHEP in
Beijing, China, is capable of measuring nucleon form factors with
unprecedented precision. We report recent results achieved by the BESIII
collaboration concerning the nucleon time-like form factors and the
hyperon pair production. Specifically, we outline the results obtained
by the study of the process e^+e^- \to p \overline pe+e−→pp¯,
using both the scan-energy and initial-state radiation techniques, those
of the process e^+e^- \to n \overline ne+e−→nn¯,
and the study of the \SigmaΣ
polarization regarding the process e^+e^- \to J/\psi \to \Sigma^+\overline \Sigma{}^-e+e−→J/ψ→Σ+Σ¯−.
PREDICTORS OF FAILURE OF ENDOSCOPIC RETROGRADE CHOLANGIOGRAPHY IN CLEARANCE OF BILE DUCT STONES ON INITIAL PROCEDURE: A MOROCCAN RETROSPECTIVE STUDY
Authors: Benhamdane A. , Mrabti S. , Addajou T. , Sair A. , Berraida R. , El Koti I. , Rouibaa F. , Benkirane A. , Seddik H.
Published: August 2022

Aims: Evaluate the predictive factors of failure rate of clearing the biliary system from stones at the initial ERCP. Methods: This is a retrospective descriptive and analytical study from September 2002 to September 2021. All patients with bile duct stones, who underwent ERCP with endoscopic sphincterotomy and stone extraction by standard techniques (extraction balloon or Dormia basket) were included in this study. Results: A total of 1080 ERCPs were performed to extract biliary duct stones. The mean age was 58.9 +/- 14.4 years and 59.5% were females. The mean diameter of the Bile duct was 13.4+/- 4.31 mm. The presence of a biliary stricture in 6.3%. The primary vacuity rate was 75.1%. Supplementary techniques were used in 22.7% of cases. On multivariate analysis, only the presence of cholangitis (OR:1.9 CI95%: 0.2-1 p=0.001), impacted and/or large stone (OR:2.5 CI95%:0.5-1.3 p<0.001), dilatation of the CBD >15mm (OR:0.88 CI95%: -0.17- -0.07 p<0.001), and biliary stricture (OR:2.9 CI95%:0.4-1.7 p=0.002) were significantly associated with failure of the primary CBD vacuity rate. The overall vacuity rate after using the supplementary techniques was 92.4%. Conclusion: In our study, predictive factors for failure of the primary CBD vacuity rate were the presence of cholangitis, impacted and/or large stone, dilatation of the CBD (>15mm) and biliary stricture.
BURDEN OF NON-COMMUNICABLE DISEASES AMONG CHILDREN IN MOROCCO
Authors:   Regional Directorate of Health and Social Protection Region of Marrakech Safi., HABABA Hanane , AIT MOH Mohammed ,   Regional Directorate of Health and Social Protection Region of Marrakech Safi.
Published: August 2022

Noncommunicable diseases remain important public health problems worldwide, accounting for significant mortality and morbidity. Noncommunicable diseases (NCDs) are the leading causes of death and disability worldwide. According to WHO (2018), Non-communicable diseases (NCDs) kill 41 million people each year, accounting for 71% of deaths worldwide. It predicts that the rapid growth of NCDs will impede poverty reduction initiatives in low-income countries, particularly due to rising out-of-pocket health expenditures.In Morocco, the situation is also problematic. The epidemiological and demographic transition is reflected in an increase in the burden of disease and mortality of NCDs in children 0- 18 years, particularly cancers, diabetes, cardiovascular diseases, chronic respiratory diseases and chronic renal failure. At the level of the Marrakech-Safi Region, the total number of diabetic children reached 1519 cases in 2019 of which 162 new cases and 1357 old cases, with a predominance (55%) at the level of the city of Marrakech. For children with hypertension, they represent 749 cases in 2019 including 25 new cases and 724 old cases. As for respiratory infections, the number of cases of acute viral bronchiolitis declared at the level of the region during the autumn-winter period 2019-2020 has reached 8404 cases. Finally, for children suffering from chronic renal failure a total number of 35 children are currently under care at the level of public hemodialysis centers, including 21 children hemodialysis, 12 under peritoneal dialysis and 02 kidney transplanted. The objective of this article is to describe the burden of morbidity and mortality related to non-communicable diseases in the Marrakech-Safi region.
A CROSS SECTIONAL STUDY ON ASSESSMENT OF THE RISK OF DEVELOPING TYPE2 DIABETES MELLITUS USING INDIAN DIABETIC RISK SCORE (IDRS) AMONG THE FEMALE SANITARY WORKERS OF A TERTIARY CARE CENTRE IN CHENGALPATTU DISTRICT, TAMILNADU
Authors:   Associate Professor, Department of Community Medicine, Chengalpattu Medical College, Chengalpattu, Tamilnadu., Getrude Banumathi P. , Sujatha S. ,   Assistant Professor, Department of Community Medicine, Chengalpattu Medical College, Chengalpattu, Tamilnadu., Dharmendiran A. ,   Post Graduate, Department of Community Medicine, Chengalpattu Medical College, Chengalpattu, Tamilnadu.
Published: August 2022

Introduction: Currently 537 million peoples globally and 74.2 million peoples in India are living with Diabetes. This is projected to 134 million in India and 783 million globally by 2045 . This study uses Indian Diabetic Risk Score for assessment of risk status in sanitary workers in tertiary care centre . Objective: 1.To assess the risk of developing Type2 Diabetes Mellitus using Indian Diabetic Risk Score (IDRS) among the female sanitary workers of a tertiary care centre in Chengalpattu . 2. To classify the risk status using Random Blood Sugar level among the study participants. Methodology: A cross sectional study was conducted among 103 female sanitary workers in Chengalpattu Medical College during June 2022 . After obtaining Institutional Ethical Committee permission ,the data was collected by using semi structured questionnaire. Anthropometric measurements and Random Blood Sugar testing were done and IDRS risk score was assessed. The data was entered in Microsoft Excel and analyzed using SPSS version 25. Result : The mean age of the study participant was 42.43 Â± 8.182 years . Among the 103 study participants , 65.0% had medium risk, 25.2% had high risk . There was a statistically significant association was found between increase in age(p=0.000*) , Waist Circumference(p=0.000*) , and BMI (p=0.006*) with IDRS risk status. Conclusion: Majority of the study participant belonged to medium risk followed by high risk group. Hence IDRS is a simple and cost effective screening tool for early identification of risk of developing Diabetes.
TRICHOBEZOARDGASTRODUODENALRECIDIVANT : A PROPOS DUN CAS
Authors:   Service de Chirurgie A, Hopital Ibn Sina, Rabat, Maroc., Zohra Ben Moula Fatima , Arsalan Othman ,   Service de Chirurgie A, Hopital Ibn Sina, Rabat, Maroc., Ihab Youssef ,   Service de Chirurgie A, Hopital Ibn Sina, Rabat, Maroc., Omar El Malki Hadj ,   Service de Chirurgie A, Hopital Ibn Sina, Rabat, Maroc., Mountacer Charif Chefchaouni Al ,   Service de Chirurgie A, Hopital Ibn Sina, Rabat, Maroc., Lahcen Ifrine ,   Service de Chirurgie A, Hopital Ibn Sina, Rabat, Maroc., Abdelkader Belkouchi ,   Service de Chirurgie A, Hopital Ibn Sina, Rabat, Maroc.
Published: August 2022

Le trichobezoard, etant une affection marqueepar la formation de concretions a partir de cheveux, qui touche essentiellement des jeunes filles perturbees par des desordres psychologiques. Nous rapportons un cas dune jeune fille, hospitalisee pour recidive de trichobezoard. La fibroscopie gastrique a pose le diagnostic, qui en general est facile en presence dun contexte evocateur. Une exerese chirurgicale a ete realisee a travers une gastrotomie, sans complications. Un suivi psychiatrique de la patiente a ete recommande, element primordial dans la prise en charge globale de cette pathologie.
PRESENTATION INHABITUELLE DUNE TUBERCULOSE EXTRAPULMONAIRE: UN ABCES FROID THORACIQUE ET REVUE DE LITTERATURE
Authors:   Departement De Pneumo-Phtisiologie, Hopital Moulay Youssef, CHU Ibn Sina, Universite Mohamed V, Rabat, Maroc., A. Anissa-Sahan Abdoulkader , Mouhoubo Ibrahim ,   Laboratoiredanatomopathologie, CHU Ibn Sina, Universite MohamedV, Rabat, Maroc., Majda Moutahir ,   Departement De Pneumo-Phtisiologie, Hopital Moulay Youssef, CHU Ibn Sina, Universite Mohamed V, Rabat, Maroc., Papys Mendes ,   Laboratoiredanatomopathologie, CHU Ibn Sina, Universite MohamedV, Rabat, Maroc., Bourkadi Jamaleddine ,   Departement De Pneumo-Phtisiologie, Hopital Moulay Youssef, CHU Ibn Sina, Universite Mohamed V, Rabat, Maroc.
Published: August 2022

Tuberculosis (TB) isa major global public healthconcern. The extrapulmonary manifestations ofTB can bemisleading and challenging todiagnose.Thoracic cold abscessis a rare and unusualentity of TB.Itrepresents 1-5% of musculoskeletal localisations of TB and constitutes a differentialdiagnosiswithpyogenicabscess, slow-growingpathogens or walltumours. In endemic areas, anypainless progressive abscessshouldsuggest a tuberculosis infection. Despite the clear diagnostic contribution of molecularbiologywith the Xpert MTB/Rif, a positive culture on a sample of fluid or tissue remains the gold standard. The management of tuberculousthoracicabscessiscontroversial and the combination of standard chemotherapy and surgeryseems to be the mostappropriate. Hereinwe report a case of a cold thoracicabscess in a 35-year-old man with no previoushistory.
A CRITICAL REVIEW OF KUSHMANDAGHRITAIN THE MANAGEMENT OF GENERALIZED TONIC-CLONIC SEIZURES
Authors:   Final Year PG Scholar, Department of Kayachikitsa KAHERS Shri B M Kankanawadi Ayurveda Mahavidyalaya, Belagavi., Priya G. Krishna , Bhaskar S. Vijay ,   Final Year PG Scholar, Department of PanchakarmaKAHERS Shri B M Kankanawadi Ayurveda Mahavidyalaya, Belagavi.
Published: August 2022

Epilepsy is a chronic disorder characterized by the appearance of frequent seizure episodes associated with a diverse group of symptoms. Generalized tonic-clonic seizure is the most common type of motor seizure usually associated with impaired awareness or complete loss of consciousness. Despite all the available medications one third of the people with epilepsy still seems to be severely affected. Management of Epilepsy still remains a challenge to the medical community. Therapeutic add-ons to the mainline antiepileptic drugs might help in overcoming this challenge.Kushmanda ghrita1is one of the simple formulations described in Ashtanga Hridaya for the management of apasmara (epilepsy).This review focuses on the comprehensive management of generalized tonic-clonic seizure with a unique formulation Kushmandaghritapracticed sinceageoldd.
FORENSICS FRAMEWORK FOR MURDER INVESTIGATIONS
Authors:   Assistant Professor of Law, Institute of Law, Nirma University., Devarhubli Gururaj , Sarfaraj Patel Bushra ,   Student of 4th Year, 8th Semester B.A.LL.B., Parul Institute of Law, Parul University.
Published: August 2022

The article forms the basics for forensic methods of homicide investigation, identifies typical investigative situations and directions for their solution. It is proved that the perpetrators identity in the structure of the forensic characterization of murders should be investigated in two directions: the first one is to obtain information on the basis of the material and ideal traces the second one is the study of the perpetrators identity during the pre-trial investigation. The methodology for investigating homicides s is based on typical investigative situations that are developed at the initial stage of criminal proceedings. Typical situations of the initial period of the investigation depend on the actions of the offender, the place, time, conditions of the murder, and the content of the source information. Forensic recommendations for their implementation are proposed.
STRESS COPING STRATEGIES ADOPTED BY PREGNANT STUDENTS IN THE UNIVERSITY OF CAPE COAST AND THEIR IMPLICATIONS FOR COUNSELLING
Authors:   Counselling Centre, University of Cape Coast, Ghana., Kyeremeh Tawiah (PhD) Dabone , Grace Yeboah ,   AkentenAppiah-Menka University of Skills Training and Entrepreneurial Development, Department of Interdisciplinary Studies., Agyeman Emma Poku ,   St. Monicas College of Education, Mampong, Ghana., Ineke Bossman Fabea ,   Department of Guidance and Counselling University of Cape Coast, Ghana.
Published: August 2022

Both being pregnant and being in school are important conditions and obligations at different points in ones life. Due to the fact that both of these things can be stressful and demanding, the purpose of this study was to evaluate the stress coping mechanisms used by pregnant student women in order to manage their stress. One research question and three hypotheses served as the basis for this investigation. For the purpose of the study, a convenient sample size of 178 participants was selected to participate. It was discovered that talking to a friend or family member was the most common method of coping utilised by the student women who were pregnant. However, there was not a statistically significant difference between the ages of the respondents, the colleges they attended, or the year in which they were enrolled in terms of the coping techniques they employ in order to manage their stress. It was inferred that specific guidance programmes geared toward helping these distinct groups of kids have a successful transition during this time of their education are required to be put into place.
FREQUENCE DES INCLUSIONS DENTAIRES DANS UNE POPULATION MAURITANIENNE
Authors:   Centre Hospitalier Regional De Nouadhibou., EL Moctar Hemdou , Mohamed Veten ,   Centre Hospitalier National De Nouakchott.
Published: August 2022

The aim of thisstudywas to determine the prevalence of dental impactions in a Mauritanian population. This is a retrospective cross-sectionalstudy of 1000 patients. Panoramic radiographs were reviewed for any abnormalitie.
HEALTH PROMOTION STRATEGIES FOR REDUCING GENDER- BASED VIOLENCE AGAINST ADOLESCENTS IN NIGERIA
Authors:   Department of Community Health, School of health sciences, Abia State College of Health Sciences and Management Technology, Aba, Nigeria., Ngozi Constance Ejimonu , Chidozie Bright Ogbonna ,   Department of Public health, School of Health Sciences, Abia State College of Health Sciences and Management Technology, Aba, Nigeria., Prince Obieze Adimuko ,   Department of Environmental Health, School of Health Sciences,Abia State College of Health Sciences and Management Technology, Aba, Nigeria., Joan Chinyere Oparaji ,   Department of human Kinetics and Health Education, Faculty of Education, NnamdiAzikiwe University, Awka, Anambra.
Published: August 2022

Gender- based violence is fundamentally, a violation of human rights.It is progressively oppressive systemic violence human rights. GBV affects both male and female gender more especially girls and young women more than boys. It occurs in all parts of the globe, cutting across all economic and social groups. This paper therefore, examined gender- based violence against adolescents in Nigeria. It elaborated factors that promulgatethis oppressive form of gender inequality which include: cultural practices, patriarchal systems that seek to control the lives and sexuality of girls, emergencies circumstances and societal norms. It also pointed out likely places of GBVoccurrences, its agonizing effects on adolescents and the prevailing circumstances in Nigeria. Salutogenic theory was deemed appropriate for the study. The study concluded that every girl and boy deserve to grow up free from harm and violence as GBV will effectively exacerbate their life cycles and continually risk their futures if un-halted. Thus, health promotion strategies were recommended as a way of reducing gender- based violence against adolescents in Nigeria.
A CASE OF SNAKE BITE WITH UNUSUAL COMPLICATIONS AND REVIEW OF LITERATURE
Authors:   Associate Prof, Department of Medicine, DVVPFs Medical College, Ahmednagar (Maharashtra) India., Khare A.B. , Tyagi Arun ,   Prof and HOD, Department of Medicine, DVVPFs Medical College, Ahmednagar (Maharashtra) India., Neve Gaurav ,   Resident, Department of Medicine, DVVPFs Medical College, Ahmednagar (Maharashtra) India., Srivastava A. K. ,   Prof, Department of Medicine, DVVPFs Medical College, Ahmednagar (Maharashtra) India., Waran M.S. ,   Prof, Department of Medicine, DVVPFs Medical College, Ahmednagar (Maharashtra) India.
Published: August 2022

Snakebites, including poisonous ones, are common occurrence in tropical countries and are endemic during summer months. However, snake bite remains a neglected public health problem in resource limited countries like India. The snake venom may cause local cytotoxicity, hemotoxicity, neurotoxicity and myotoxicity. Cardiac involvement is not usually encountered and has not been extensively discussed. It is however reflected in ECG changes, echocardiographic changes, raised cardiac enzymes and new unexplained cardiac events.We recently managed case of cobra envenomation who presented with features of cytotoxicity leading to extensive cellulitis, coagulopathy and neuroparalysis. He was managed with polyvalent anti-snake venom (ASV) administration and supportive treatment. He recovered from neuroparalysis and was successfully weaned off the ventilator. Three days later, he developed ischemic cerebral infarction and left ventricular failure (LVF). Electrocardiography showed fresh ST-T changes in anterior and inferior leads. Echocardiography revealed features of severe, left ventricular (LV) dysfunction, markedly reduced ejection fraction (LVEF 20-25%) and mid-basal to apical akinesia. The patients LVF was managed with diuretic and resolved over next 48 h. Repeat echo after three days showed marked improvement in LVEF to 50% and only mild hypokinesia of akinetic segments. The transient LVF and echo findings were suggestive of the diagnosis of stress (Takotsubo) cardiomyopathy. We report this case for its unusual complications and review the relevant literature.
MID ILEAL DUPLICATION CYST WITH ECTOPIC GASTRIC MUCOSA DETECTED BY TECHNETIUM-99M PERTECHNETATE
Authors: A. Barnawi Nawal , Altayeb Ibrahim , E. Taybe Maysa , A. Mohammed Meshal
Published: August 2022

Gastrointestinal duplication cysts are a rare congenital malformation in the gastrointestinal tract, most commonly seen in the ilium. The present study reported a child with a mid ileal duplication cyst ofthe ectopic gastric mucosa that was diagnosed by Technetium-99m pertechnetate single-photon emission computed tomography-computed tomography (SPECT-CT) scintigraphy. Gastrointestinal duplication cysts can present with massive lower gastrointestinal bleeding in early childhood Technetium-99m pertechnetate (Meckel scan) with SPECT-CT can help reach the diagnosis and decrease morbidity and mortality.
VALORIZATION OF MATERIALS FROM ROAD WASTES: CASE OF THE SEASHELL AGGREGATE
Authors:   Research Scholar, Unversity Institute of Technology of Iba Der Thiam University in Thies, Senegal., Diokhane Astou , Sow Djibril ,   Research Teacher, Unversity Institute of Technology of Iba Der Thiam University in Thies, Senegal., Khalil Cisse Ibrahima ,   Research Teacher, Polytechnic School of Thies, Senegal.
Published: August 2022

The main objective of this study is to see to what extent it is possible to recover a material from road waste: the case of the seashell aggregate. Public works produce 100 millions tonnes of surplus and construction waste every year. Among the 100 million tons, 95% is inert and non-polluting waste. And faced with the ever-increasing demand for road construction materials and the scarcity of materials satisfying the specifications, it is urgent to initiate study programs on the possibility of using the materials in place in order to anticipating the total exhaustion of careers. In road works, and in particular for making embankments and capping layers, the bearing capacity of the soil, i.e. its resistance to rupture, is determined by the test C.B.R. (Californian Bearing Ratio) or Californian lift test. Thus, after characterization, the seashell aggregate from road waste was improved with Portland cement with different percentages. We find with a treatment at 1.5% then 2.5% respective CBR values â€‹â€‹of 94 and 140. This work shows that these materials can be reused in road construction.
COMPARATIVE EVALUATION OF GINGIVAL CREVICULAR FLUID AND SALIVARY SCLEROSTIN LEVELS IN CHRONIC PERIODONTITIS PATIENTS WITH OR WITHOUT TYPE 2 DIABETES MELLITUS: A CROSS-SECTIONAL STUDY
Authors: G.K Prerana , A.M Savita , Nanaiah Pallavi , S. Sunil , Naik Archana , MB Harsha
Published: August 2022

Introduction: Chronic Periodontitis is an infectious disease resulting in inflammation within the supporting tissues of the teeth leading to progressive attachment and bone loss. Biochemical mediators in oral fluids like saliva and gingival crevicular fluid (GCF) are highly beneficial in the determination of current periodontal status. Aim & objective: A comparative evaluation of GCF and salivary sclerostin levels in chronic periodontitis patients with or without type 2 diabetes mellitus Methodology: A total of 36 subjects in the age group of 30-60 years were categorised into three groups. Group I (Healthy individuals) Group II (chronic periodontitis patients) and Group III (chronic periodontitis patients with type 2 diabetes mellitus). During the first visit the clinical parameters like Plaque index, Gingival index, Probing pocket depth and Clinical attachment level were recorded. On the subsequent day GCF and saliva samples were collected and subjected for laboratory analysis using ELISA kit. Results were tabulated and subjected to statistical analysis. Results & Discussion: The differences of Sclerostin levels in Saliva between the groups were not statistically significant (P = 0.089). The differences of Sclerostin levels in GCF between the groups were highly statistically significant (P =0.000). Conclusion: Sclerostin levels are a promising diagnostic and prognostic biomarker in periodontal diseases.
EFFECTIVENESS OF VAT ON SELECTED STRATEGIES TO IMPROVE HEALTH RELATED QUALITY OF LIFE OF ELDERLY
Authors:   Principal, Eashwari Bai Memorial College of Nursing, Secunderabad, Telangana, India., Kumari B.N.P , Krishna P. Sai ,   Eashwari bai Memorial College of Nursing, Secunderabad, Telangana, India., Maria Therese A. ,   Professor, Mother Theresa Post Graduate Research Institute of Health Sciences College of Nursing, Puducherrry, India.
Published: August 2022

A pre-experimental study with one group pretest posttest design was conducted to assess the effectiveness of Video assisted teaching programme on selected strategies to improve health related quality of life of elderly residing in selected old age homes at Hyderabad, Telangana. Non probability convenient sampling technique was used to select 40 Elderly. The mean percentage of overall knowledge score in the pretest was 29 (72.5%) with standard deviation of 3.112 and 34 (85%) in the post test with standard deviation of 3.817. The obtainedt value 21.88 is greater than the table value 2.05 and found to be highly significant at the level of p<0.05. So it is evident that the Video assisted teaching programme was effective in increasing the knowledge level of Elderly on selected health strategies. There was significant association between posttest knowledge scores with education and average sleep per day of demographic variables of elderly.
THE DEVELOPMENT OF A COMPUTATIONAL BASED LEARNING MODEL TO IMPROVE COMPUTATIONAL THINKING ABILITY IN PHYSICS LEARNING IN THE SENIOR HIGH SCHOOL
Authors:   Master of Science Education Student, Faculty of Teacher Training and Education, Jember University, Indonesia., Khoirul Huda M. , a Indrawati ,   Master of Science Education Lecturer, Faculty of Teacher Training and Education, Jember University, Indonesia., Mudakir Imam ,   Master of Science Education Lecturer, Faculty of Teacher Training and Education, Jember University, Indonesia.
Published: August 2022

The purpose of this research is to produce a valid Computational Based Learning (CBL) model to improve computational thinking skills. The research design that will be used is the design development of Research and Development Borg & Gall. The results of the validation of the Computational Based Learning (CBL) learning model were carried out by 3 validators with an average score of 90.25% with a very valid category. The results of computational thinking skills have also increased, as evidenced by students being able to identify and decide important things from the data information provided (Abstraction), combine existing physics concepts (Generalization), get formulations from combination results (Decomposition), use computer programs (applications) to represent in graphical form (Alghoritm), and find, identify and fix syntax errors (debugging). Then from the observations made, it was stated that the ability of students to experience a significant increase in scientific literacy and computational thinking after the implementation of the Computational Based Learning (CBL) learning model.
Features of the course of atopic dermatitis with facial and neck lesions (head and neck)
Authors: Tamrazova O. B. , Glukhova E. A. , Tamrazova A. V.
Published: August 2022

Dermatitis of head and neck, also known as “head-and-neck dermatitis” (HNAD), is one of the specific manifestations of atopic dermatitis (AD) in adolescents and young adults. The epidermal barrier dysfunction, skin pathological immune responses, a direct damaging effect of the malassezial flora through the synthesis of virulence factors and mediated by maintaining immune inflammatory responses, as well as the attachment of secondary bacterial flora caused by scratching form the basis of pathogenetic mechanisms of this condition. The properties that define the HNAD rash is a focus on the seborrheic areas (a face, front surface of the neck, décolleté on the chest), severe itching, prolonged course, exacerbation characterized by excessive sweating. It appears that fungi of the genusMalasseziacan play a role in the development of the disease. While they are considered to be part of the normal skin microbiome, a significant increase in the severity of atopic dermatitis was observed in patients with Malassezial flora, which was the reason for the theories devoted to the role ofMalassezia spp. as a trigger of the disease. Atopic dermatitis can also develop as a side effect of using targeted therapy with IL4/13 blockers, which is explained at the present day by a shift of the immune response towards a Th-17-mediated reaction. The combination of both infectious and immune-mediated lesions in HNAD determines the necessity of an integrated approach to the therapy, in particular the use of topical combination drugs as  the first-line therapy. The topical glucocorticosteroid (TGCS) therapy is aimed at suppressing the immune reactions that are responsible for inflammation in the skin, antifungal therapy is required to suppress the activity of the malassesial flora, and, finally, a secondary bacterial infection requires the prescription of topical antibacterial drugs.
TNF-α gene expression in immune cells of patients with psoriasis and psoriatic arthritis
Authors: Sobolev V. V. , Chebysheva S. N. , Geppe N. A. , Katkova K. V. , Soboleva A. G. , Korsunskaya I. M.
Published: August 2022

Introduction. Psoriatic disease is a heterogeneous inflammatory disease with different clinical manifestations, including plaque psoriasis and psoriatic arthritis. It has been shown that elevated levels of TNF-α are observed in both psoriatic arthritis and psoriasis. Studying the TNF-α gene expression pattern can help in the differential diagnosis between psoriatic arthritis and psoriasis.

The objective is to study the TNF-α gene expression pattern in blood mononuclear cells of patients with psoriatic arthritis and psoriasis for possible differential diagnosis between these two diseases.

Materials and methods. Mononuclear cells were isolated from the peripheral blood of 31 patients with plaque psoriasis, 45 patients with psoriatic arthritis and 20 healthy controls. The expression level of the TNF-α gene was analysed using a real-time PCR method.

Results and discussion. As a result of the comparison, the expression level of TNF-α in patients with psoriatic arthritis was found to be 179 times higher than the expression level in healthy volunteers. The expression level of TNF-α in patients with psoriasis was also significantly (106 times) higher than the expression level in healthy people. We managed to identify a significant difference between patients with psoriatic arthritis and psoriasis.

Conclusions. Patients with psoriasis in terms of TNF-α gene expression level in mononuclear cells are close to the condition of patients with psoriatic arthritis. A high level of TNF-α gene expression can become a marker of possible joint injury in patients with psoriasis and a signal to revise the therapeutic approach to a particular patient.
Perceived stress, emotional intelligence and psychological wellbeing of mental health professionals puring covid-19 in Pakistan
Authors: Qamar Tania , Mariamdaran Chethiyar Saralah Devi , Equatora Muhammad Ali
Published: August 2022

AbstractPurpose - The aim of the research was to assess the relationship between perceived stress, emotional intelligence and psychological wellbeing of mental health professionals during Covid-19 in Pakistan.Method - The population of this study is (n=150) mental health professionals (psychologists, psychiatrists, psychiatry nurses). Data was collected through purposive sampling strategy.Result - The results showed that perceived stress has significant negative association with psychological wellbeing, however, emotional intelligence has significant positive association with psychological wellbeing. Regression findings revealed that perceived stress and emotional intelligence were significant predictors of psychological wellbeing among mental health professionals. ANOVA findings showed psychological wellbeing score was high in psychiatrists then other mental health professionals.Implication – This research guided to enhance the emotional intelligence skill. The present study will help to understand the importance of psychological wellbeing especially among mental health professionals.Originality - The present study has great importance for mental health professionals. The results of the current study have suggestions for theories in the field of socialization to understand the perceived stress, emotional intelligence and psychological wellbeing mostly experienced, which increase our knowledge.***Tujuan - Penelitian ini bertujuan untuk menilai hubungan antara stres yang dirasakan, kecerdasan emosional, dan kesejahteraan profesional kesehatan mental selama Covid-19 di Pakistan.Metode - Populasi penelitian ini adalah (n=150) tenaga kesehatan jiwa (psikolog, psikiater, perawat psikiatri). Data dikumpulkan melalui strategi purposive sampling.Hasil - Hasil penelitian menunjukkan bahwa persepsi stres memiliki hubungan negatif yang signifikan dengan kesejahteraan, namun kecerdasan emosional memiliki hubungan positif yang signifikan dengan kesejahteraan. Temuan regresi mengungkapkan bahwa stres yang dirasakan dan kecerdasan emosional merupakan prediktor signifikan kesejahteraan di kalangan profesional kesehatan mental. Temuan ANOVA menunjukkan skor kesejahteraan lebih tinggi pada psikiater daripada profesional kesehatan mental lainnya.Implikasi - Penelitian ini dipandu untuk meningkatkan keterampilan kecerdasan emosional. Studi ini akan membantu untuk memahami pentingnya kesejahteraan, terutama di kalangan profesional kesehatan mental.Originalitas - Penelitian ini sangat penting bagi para profesional kesehatan mental. Hasil penelitian saat ini memiliki saran untuk teori di bidang sosialisasi untuk memahami stres yang dirasakan, kecerdasan emosional, dan kesejahteraan sebagian besar dialami, yang meningkatkan pengetahuan kita.