bluuebunny/crossref_metadata_2025 huggingface dataset:
Mechanical Thrombectomy for Minor and Mild Stroke Patients Harboring Large Vessel Occlusion in the Anterior Circulation
Authors: Dargazanli Cyril , Arquizan Caroline , Gory Benjamin , Consoli Arturo , Labreuche Julien , Redjem Hocine , Eker Omer , Decroix Jean-Pierre , Corlobé Astrid , Mourand Isabelle , Gaillard Nicolas , Ayrignac Xavier , Charif Mahmoud , Duhamel Alain , Labeyrie Paul-Emile , Riquelme Carlos , Ciccio Gabriele , Smajda Stanislas , Desilles Jean-Philippe , Gascou Grégory , Lefèvre Pierre-Henri , Mantilla-García Daniel , Cagnazzo Federico , Coskun Oguzhan , Mazighi Mikael , Riva Roberto , Bourdain Frédéric , Labauge Pierre , Rodesch Georges , Obadia Michael , Bonafé Alain , Turjman Francis , Costalat Vincent , Piotin Michel , Blanc Raphaël , Lapergue Bertrand , Wang Adrien , Evrard Serge , Tchikviladzé Maya , Gonzalez-Valcarcel Jaime , Di Maria Federico , Pico Fernando , Rakotoharinandrasana Haja , Tassan Philippe , Poll Roxanna , Corabianu Ovide , de Broucker Thomas , Smadja Didier , Alamowitch Sonia , Ille Olivier , Manchon Eric , Garcia Pierre-Yves
Published: October 2017

Background and Purpose—

Proximal large vessel occlusion (LVO) is present in up to 30% of minor strokes. The effectiveness of mechanical thrombectomy (MT) in the subgroup of minor stroke with LVO in the anterior circulation is still open to debate. Data about MT in this subgroup of patients are sparse, and their optimal management has not yet been defined. The purpose of this multicenter cohort study was to evaluate the effectiveness of MT in patients experiencing acute ischemic stroke (AIS) because of LVO in the anterior circulation, presenting with minor-to-mild stroke symptoms (National Institutes of Health Stroke Scale score of <8).

Methods—

Multicenter cohort study involving 4 comprehensive stroke centers having 2 therapeutic approaches (urgent thrombectomy associated with best medical treatment [BMT] versus BMT first and MT if worsening occurs) about management of patients with minor and mild acute ischemic stroke harboring LVO in the anterior circulation. An intention-to-treat analysis was conducted. The primary end point was the rate of excellent outcome defined as the achievement of a modified Rankin Scale score of 0 to 1 at 3 months.

Results—

Three hundred one patients were included, 170 with urgent MT associated with BMT, and 131 with BMT alone as first-line treatment. Patients treated with MT were younger, more often received intravenous thrombolysis, and had shorter time to imaging. Twenty-four patients (18.0%) in the medical group had rescue MT because of neurological worsening. Overall, excellent outcome was achieved in 64.5% of patients, with no difference between the 2 groups. Stratified analysis according to key subgroups did not find heterogeneity in the treatment effect size.

Conclusions—

Minor-to-mild stroke patients with LVO achieved excellent and favorable functional outcomes at 3 months in similar proportions between urgent MT versus delayed MT associated with BMT. There is thus an urgent need for randomized trials to define the effectiveness of MT in this patient subgroup.
Predictors of Good Outcome After Endovascular Therapy for Vertebrobasilar Occlusion Stroke
Authors: Bouslama Mehdi , Haussen Diogo C. , Aghaebrahim Amin , Grossberg Jonathan A. , Walker Gregory , Rangaraju Srikant , Horev Anat , Frankel Michael R. , Nogueira Raul G. , Jovin Tudor G. , Jadhav Ashutosh P.
Published: October 2017

Background and Purpose—

Endovascular therapy is increasingly used in acute ischemic stroke treatment and is now considered the gold standard approach for selected patient populations. Prior studies have demonstrated that eventual patient outcomes depend on both patient-specific factors and procedural considerations. However, these factors remain unclear for acute basilar artery occlusion stroke. We sought to determine prognostic factors of good outcome in acute posterior circulation large vessel occlusion strokes treated with endovascular therapy.

Methods—

We reviewed our prospectively collected endovascular databases at 2 US tertiary care academic institutions for patients with acute posterior circulation strokes from September 2005 to September 2015 who had 3-month modified Rankin Scale documented. Baseline characteristics, procedural data, and outcomes were evaluated. A good outcome was defined as a 90-day modified Rankin Scale score of 0 to 2. The association between clinical and procedural parameters and functional outcome was assessed.

Results—

A total of 214 patients qualified for the study. Smoking status, creatinine levels, baseline National Institutes of Health Stroke Scale score, anesthesia modality (conscious sedation versus general anesthesia), procedural length, and reperfusion status were significantly associated with good outcomes in the univariate analysis. Multivariate logistic regression indicated that only smoking (odds ratio=2.61; 95% confidence interval, 1.23–5.56;
P
=0.013), low baseline National Institutes of Health Stroke Scale score (odds ratio=1.09; 95% confidence interval, 1.04–1.13;
P
<0.0001), and successful reperfusion status (odds ratio=10.80; 95% confidence interval, 1.36–85.96;
P
=0.025) were associated with good outcome.

Conclusions—

In our retrospective case series, only smoking, low baseline National Institutes of Health Stroke Scale score, and successful reperfusion status were associated with good outcome in patients with posterior circulation stroke treated with endovascular therapy.
On Ignored Global “Scientific Revolutions”
Authors: Cañizares-Esguerra Jorge
Published: October 2017

The categories that structure the study of early modern science are organized around the epistemological liberal regime of facts, objectivity, skepticism, print culture, the public sphere, and the Republic of Letters. The regime of early-modern science in the global Spanish Monarchy is not well known because it was forged in a very different system, one of rewards and legislation in which most activities were transacted through one-on-one epistolary correspondence and intimate transference of information in translation workshops. This global system, nevertheless, engendered ceaseless technical and scientific innovations. I study three cases: the extraction and transformation of silver ores in several spaces; the production of ships and new botanical resources that reorganized global dockyards; and the creation of local translation workshops to facilitate the circulation of knowledge within the global empire. “European” science, the “West,” and instrumental reason have always been global co-creations. However, colonial and postcolonial Manichean dichotomous historiographical categories have made this truism hard to see.
A new species of Paris (Melanthiaceae) from Yunnan, China
Authors: LIU YUYU , LUO DANDAN , YAO HUI , ZHANG XIAOCAN , YANG LIWU , DUAN BAOZHONG
Published: October 2017

Paris Linnaeus (Linnaeus 1753: 367) is the largest genus within Melanthiaceae, with more than 27 species (The Plant List 2013, Wang et al. 2017). It is widely distributed in the regions of southwestern China, especially Yunnan, Guizhou and other plateau provinces (Li 1998, Wu et al. 2004, Zhang et al. 2007, Huang et al. 2012). The genus Paris has 22 species in China, of which 14 are distributed in Yunnan (Li 1998) and five species are endemic to Yunnan; therefore, their species diversity ranks first in China (Zhao et al. 2016). Most species of Paris with a thick rhizome have been widely used in China for a long time to treat tumors, chronic bronchitis, for traumatic injuries, and as antimicrobial agent, achieving significant effect (Wu et al. 2004).
Impatiens haridasanii (Balsaminaceae), a new species from Arunachal Pradesh, northeastern India
Authors: HAREESH VADAKKOOT SANKARAN , SABU MAMIYIL
Published: October 2017

Impatiens haridasanii, a new species, is described from Longding district of Arunachal Pradesh, northeastern India. Detailed descriptions, distribution, and ecology along with colour photographs are provided.
Struthanthus ramiro-cruzii (Loranthaceae), a new species from Guerrero, Mexico
Authors: MARTÍNEZ-AMBRIZ EMMANUEL , SALDAÑA SADDAN MORALES , SORIANO-BENÍTEZ JACQUELINE V.
Published: October 2017

A new species of Struthanthus from the state of Guerrero, Mexico, is described and illustrated: Struthanthus ramiro-cruzii. It grows in oak and pine-oak forests, in the physiographic province of the Southern Coastal Range in the Guerrerense region. It is morphologically similar to S. deppeanus, but differs by having leaves with a subcordate to truncate base, a sessile central flower of the triad and a strongly convoluted style. A key to distinguish the new species from other species of the genus present in the state of Guerrero is included.
Gleadovia konyakianorum (Orobanchaceae), a new species from Nagaland, India
Authors: ODYUO N. , ROY DILIP KR. , AVERYANOV LEONID V.
Published: October 2017

A new species of the genus Gleadovia from Nagaland, Northeastern India, Gleadovia konyakianorum is here described and illustrated. The new species differs from its presently known congeners, such as G. banerjiana, G. mupinense and G. ruborum in having strictly 1-flowered inflorescence borne at stem apex, urceolate calyx unequally 5-lobed at apical part, white corolla, narrowly ovoid to fusiform, ca. 1 cm long anther, moderately shorter style, 0.5–0.6 cm long and in narrowly subulate, comparatively longer stigma, to 2.5 cm long. Identification key to the species of Gleadovia is given.
Racekiela andina sp. nov. (Spongillida: Spongillidae): first report of a freshwater sponge from the Venezuelan Andes
Authors: HERNÁNDEZ VICTOR M. Q. , BARREAT JOSÉ G. N.
Published: October 2017

The genus Racekiela Bass & Volkmer-Ribeiro, 1998 comprises six species of freshwater sponges distributed along the Palaearctic, Nearctic and Neotropical regions (Van Soest et al. 2017). They are characterized by an isodictyal skeleton solely of acanthoxeas, sparse spongin fibers, and tri-layered gemmules with radially embedded gemmoscleres of two types, short birotules and long pseudobirotules (Manconi & Pronzato 2002; Volkmer-Ribeiro & Machado 2007). Four species occur in the Northern Hemisphere: R. biceps (Lindenschmidt, 1950) from Michigan (Lindenschmidt 1950), R. pictouensis (Potts, 1885) from eastern Canada to New York (Penney & Racek 1968), R. ryderii (Potts, 1882) which ranges from eastern North America to the British Isles, Faroes and Norway (Manconi & Pronzato 2002), and the recently described R. montemflumina Carballo, Cruz-Barraza, Yáñez & Gómez, 2017 from Northwestern Mexico (Carballo et al. 2017). It is worthy to note that R. pictouensis is considered to be an ecomorph of R. ryderii by several authors (Porrier 1977; Ricciardi & Reiswig 1993). The other two species, R. cavernicola (Volkmer-Ribeiro, Bichuette & Machado, 2010) and R. sheilae (Volkmer-Ribeiro, De Rosa-Barbosa & Tavares, 1988), are both known only from Brazil (Volkmer-Ribeiro & Machado 2007; Volkmer-Ribeiro et al. 2010). Here we describe a new member of the genus, found in lakes of high-mountain ecosystems, or páramos, in the Cordillera de Mérida. This constitutes the first record of specimens belonging to Racekiela for the Andes and Venezuela.
Description of Coeliccia bhriulieci sp. nov. (Odonata: Zygoptera: Platycnemididae) from central Vietnam
Authors: TO VAN QUANG , PHAN QUOC TOAN , TRAN VAN BANG
Published: October 2017

Coeliccia bhriulieci sp. nov. (holotype male from Tay Giang district, Quang Nam province, central Vietnam, deposited in the Zoological collection of the Southern Institute of Ecology, Vietnam Academy of Science and Technology, Ho Chi Minh City, Vietnam) is described based on male specimens. The new species is easily distinguished from other Coeliccia species in the Southeast Asian region by the combination of its blue abdominal tip, black anal appendages and structure of genital ligula with two long flagella extending from lateral corners of apical segment.
Progressive tensile damage simulation and strength analysis of three-dimensional braided composites based on three unit-cells models
Authors: Dong Jiwei , Huo Ningfei
Published: October 2017

In order to explore the micro-failure mechanism and predict tensile strength of three-dimensional braided composites, the three unit-cells models, namely interior cell, surface cell and corner cell, are established to simulate progressive damage of these materials. Macro model is firstly created and divided into three kinds of unit cells by their periodical distributions. A criterion is approached to determine damage and its pattern of each element, and stiffness degradation is implemented for the damaged elements with geometric damage theory. Periodical boundary conditions are applied on the models to calculate micro-stress and damage propagation is simulated with the increase of load. Each type of damage and its percentage is obtained by simulation and micro-failure mechanism is analyzed. Furthermore, the tensile strengths are predicted from calculated stress–strain curves. From simulation, composites with large braiding angle have more complicated micro-failure mechanism than composites with small braiding angle. It is also observed that there are more damages in surface cell than in interior cell and the damage types in the surface cell are various. The predicted results on the three unit-cells models agree well with the experimental data and are more accurate than only using an interior-cell model.
Influence of void defects on progressive tensile damage of three-dimensional braided composites
Authors: Dong Jiwei , Gong Yaohua
Published: October 2017

A meso-finite element model with random voids in matrix is developed to simulate the tensile progressive damage of three-dimensional braided composites. A stiffness degradation method for generating the random void defect element in finite element method is presented. Proper criteria are adopted as initial damage of components, and stiffness degradation is implemented for damage propagation. The tensile strengths are predicted from calculated stress–strain curves. From simulation, void defects in matrix make the redistribution of micro-stress and accelerate the damage propagation of three-dimensional braided composites. Furthermore, void defects reduce the strength and ductility of the composites, but the reduction is not obvious if the porosity is controlled within a range.
Elementary 1:1 iPad Implementation: Successes and Struggles During the First Year
Authors: Frazier Denise K. , Trekles Anastasia M.
Published: October 2017

This mixed-method case study followed K-5 elementary teachers through their first year of 1:1 iPad adoption in one elementary school. All teachers in the school were surveyed in September and December 2015 and May 2016. Focus groups consisting of two teachers from each grade level were held during these same months. Teacher perceptions were gathered in regard to iPads in curriculum, management, differentiation, collaboration, assessment, and inquiry learning. Struggles during the first year included lack of professional development, rushed decisions made by administration, technical problems, and poor planning. Success was found in differentiation and improvement throughout the year.
Anterior Palatoplasty for Obstructive Sleep Apnea: A Systematic Review and Meta‐analysis
Authors: Binar Murat , Karakoc Omer
Published: October 2017

Objective

The aim of this study was to determine the general outcomes and surgical success rates of anterior palatoplasty (AP) in patients with obstructive sleep apnea (OSA).

Data Sources

A systematic review of the literature and meta‐analysis of published data were performed by searching the Cochrane, SAGE, MEDLINE, and Google Scholar databases, from January 1, 2007, to March 27, 2017, using relevant keywords.

Review Methods

The search scanned for studies with patients who had undergone AP (with or without tonsillectomy) as a single‐stage, single‐level surgical intervention for treatment of OSA. Two independent reviewers (M.B. and O.K.) inspected titles and abstracts of the studies according to established criteria. The full texts were then reviewed to extract the clinical and polysomnographic data. The primary outcome was the surgical success rate, defined as a reduction in the apnea‐hypopnea index (AHI) of 50% or greater and an AHI of less than 20 postoperatively. The PRISMA statement was followed.

Results

After systematic evaluation of potentially relevant articles, 14 studies were downloaded, and 6 studies, consisting of 170 patients, met the study criteria. A fixed effects model was used to analyze the data. The surgical success rate of AP was 60.6%. No serious complications were reported in the literature.

Conclusion

The results of the present meta‐analysis support AP as a moderately effective surgical method for the treatment of OSA. Comparative and randomized controlled prospective studies showing long‐term results, with pre‐ and postoperative data, should be conducted to demonstrate the exact outcomes and reliability of this surgical technique.
Effects of Sleep Quality on Imagery Ability in Athletic Populations
Authors: Shearer David , Bruton Adam , Short Sandra , Roderique-Davies Gareth
Published: October 2017

This study explored the relation between athletes’ sleep quality and imagery ability. A total of 201 athletes (39.3% female, 60.7% male; Mage = 23.28 years, SD = 6.00) completed the Sport Imagery Ability Questionnaire and the Pittsburgh Sleep Quality Index. Simple regression analyses revealed that global sleep quality predicted affect imagery ability. Multiple regression analyses revealed that daytime dysfunction predicted global imagery ability as well as skill, strategy, affect, and mastery imagery ability dimensions. In addition, use of sleeping medication predicted global imagery ability, as well as goal and affect imagery ability dimensions. Results provide some support for Cumming and Williams’ revised applied model of deliberate imagery use, suggesting that individual factors influence the effectiveness of imagery use. Specifically, athletes who have no disruption to daily functioning due to sleep find it easier to image sport-related content.
Alcohol Dependence in Palliative Care
Authors: MacCormac Aisling
Published: October 2017

Purpose:

Alcohol misuse affects up to 28% of palliative care inpatients. This article aims to summarize the existing literature on the care of palliative patients with alcohol dependence.

Methods:

The author searched CINAHL, Scopus, MEDLINE, and PubMed from inception until July 2017 using search terms including “alcohol*,” “dependence,” and “palliative.” The results were reported in a narrative manner.

Results:

Identification of alcohol-dependent patients can be improved through the use of validated tools such as “Cut Down, Annoyed, Guilty, Eye Opener” (CAGE) and “Alcohol Use Disorders Identification Test” (AUDIT). These patients may have specific palliative care needs such as increased susceptibility to terminal agitation, high prevalence of comorbidities, and poor social support networks. Management may involve detoxification, controlled usage of alcohol, or treatment of alcohol withdrawal.

Conclusions:

Patients may derive clinical benefit when alcohol dependence is identified by health-care professionals. Routine screening should be considered. Further research is needed to directly compare treatments for alcohol dependence in palliative care.
A novel representation method of non-ideal surface morphologies and its application in shaft-hole sealing simulation analysis
Authors: Wu Jianshun , Qiao Lihong , Zhu Zuowei , Anwer Nabil
Published: October 2017

Assembly process simulation has been recognized as an effective tool for design verification. The representation of actual part surfaces produced by manufacturing processes is an important issue for assembly simulation. Manufactured part surfaces can also be regarded as non-ideal surface morphologies caused by manufacturing errors. This article presents a new approach to describe non-ideal cylindrical surface morphologies. A deviation coordinate system is developed by adding a new deviation dimension along the normal direction of the nominal surface modeled in the cylindrical surface curvilinear coordinate system. Considering characteristics of the cylindrical surface machining process, a unified expression of combined Hermite polynomials and Fourier series is used to demonstrate deviations that commonly appear on manufactured non-ideal cylindrical surfaces. The Hermite–Fourier polynomials constitute multi-morphologies resulting from different manufacturing errors. In the proposed method, a parametric matrix is created from the expansion of the Hermite–Fourier polynomials. Each morphology can be represented by a corresponding matrix. The total deviation of a non-ideal part surface is the sum of deviations caused by each manufacturing error source through a linear combination of various matrices. The effectiveness of the proposed method is verified by a simulation of the sealing function of shaft-hole assemblies.
Preload on draft gear in freight trains
Authors: Wu Qing , Cole Colin , Spiryagin Maksym , Ma Weihua
Published: October 2017

Adjusting draft gear preloads requires minimum or no structural changes to the existing coupler systems. Better or optimal preloads are more promising to be implemented than modifying other parameters such as wedge angles and spring stiffness. This paper presents a method to model draft gear preloads and investigates the numerical step-size requirements for the simulations of draft gear preloads. The implications of preloads on the draft gear impact performance, longitudinal train dynamics performance and coupler fatigue damage were also investigated. The results show that step sizes of less than 2.5 and 0.2 ms (with the fourth Runge–Kutta solver) are recommended to simulate preloads during the simulations of longitudinal train dynamics and wagon impacts, respectively. Wagon impact simulations indicate that the increase of draft gear preloads can noticeably decrease the maximum draft gear deflection during wagon impacts. Longitudinal train dynamics simulations for a distributed power train with 214 vehicles on a 320 km long track were conducted. The longitudinal train dynamics simulations indicate that, when the preload is increased from 0 to 100 kN, the difference of maximum vehicle accelerations is insignificant. When the draft gear preload is further increased to 200 or 300 kN, maximum vehicle accelerations are evidently increased. Draft gear preloads do not noticeably influence the maximum tensile coupler forces. However, preloads have evident implications for maximum compressive coupler forces, especially for the second half of the train. Coupler fatigue damage calculations show that the sum of coupler fatigue damage evidently decreases with the increase of draft gear preload. The damage for the zero preload case is 8.7 times than that of the 300 kN preload case.
Validation of the LupusPRO version 1.8: an update to a disease-specific patient-reported outcome tool for systemic lupus erythematosus
Authors: Azizoddin D R , Weinberg S , Gandhi N , Arora S , Block J A , Sequeira W , Jolly M
Published: October 2017

Objectives

LupusPRO has shown good measurement properties as a disease-specific patient-reported outcome tool in systemic lupus erythematosus (SLE). For the purpose of clinical trials, the version 1.7 (v1.7) domain of Pain-Vitality was separated into distinct Pain, Vitality and Sleep domains in v1.8, and the psychometric properties examined.

Methods

A total of 131 consecutive SLE patients were self-administered surveys assessing fatigue (FACIT, SF-36), pain (Pain Inventory, SF-36), insomnia (Insomnia Severity Index), emotional health (PHQ-9, SF-36) and quality of life (SF-36, LupusPRO) at routine care visits. Internal consistency reliability (ICR) for each domain was obtained using Cronbach’s alpha. The convergent construct validity of LupusPRO domains with corresponding SF-36 domains or tools were tested using Spearman correlation. Varimax rotations were conducted to assess factor structures of the LupusPRO v1.8.

Results

Mean (SD) age was 40.04 (14.10) years. Scores from the LupusPRO-Sleep domain strongly correlated with insomnia scores, while LupusPRO-Vitality correlated strongly with fatigue (FACIT) and SF-36 vitality. The LupusPRO-Pain domain correlated strongly with pain (SF36 Bodily-Pain, Pain Inventory) scores. Similarly, the LupusPRO domains of Physical and Emotional Health had significant correlations with corresponding SF-36 domains. The ICR for HRQoL and non-HRQoL were 0.96 and 0.81. LupusPRO (domains HRQoL and QoL) scores correlated with disease activity. Principal component analysis included seven factor loadings presenting for the HRQOL subscales (combined Sleep, Vitality, and Pain), and three factors for the NHRQoL (Combined Coping and Social Support).

Conclusions

LupusPRO v1.8 (including its Sleep, Vitality, and Pain domains) has acceptable reliability and validity. Use of LupusPRO as an outcome measure in clinical trials would facilitate responsiveness assessment.
Acoustical correlates of perceptual blend in timbre dyads and triads
Authors: Lembke Sven-Amin , Parker Kyra , Narmour Eugene , McAdams Stephen
Published: October 2017

Achieving a blended timbre for particular combinations of instruments, pitches, and articulations is a common aim of orchestration. This involves a set of factors that this study jointly assesses by correlating the perceptual degree of blend with the underlying acoustical characteristics. Perceptual blend ratings from two experiments were considered, with the stimuli consisting of: 1) dyads of wind instruments at unison and minor-third intervals and at two pitch levels, and 2) triads of wind and string instruments, including bowed and plucked string excitation. The correlational analysis relied on partial least-squares regression, as this technique is not restricted by the number and collinearity of regressors. The regressors encompassed acoustical descriptors of timbre (spectral, temporal, and spectrotemporal), as well as acoustical descriptors accounting for pitch and articulation. From regressor loadings in principal-components space, the major regressors leading to substantial and orthogonal contributions were identified. The regression models explained around 90% of the variance in the datasets, which was achievable with less than a third of all regressors considered initially. Blend seemed to be influenced by differences across intervals, pitch, and articulation. Unison intervals yielded more blend than did non-unison intervals, and the presence of plucked strings resulted in clearly lower blend ratings than for sustained instrument combinations. Furthermore, prominent spectral features of instrument combinations influenced perceived blend.
Sleep Disturbance Mediates the Association of Post-Traumatic Stress Disorder Symptoms and Pain in Patients With Cancer
Authors: Lillis Teresa A. , Gerhart James , Bouchard Laura C. , Cvengros Jamie , O’Mahony Sean , Kopkash Katherine , Kabaker Katherine B. , Burns John
Published: October 2017

Background:

Sleep disturbance is a common complaint of patients with cancer and is well established in both pain conditions and post-traumatic stress disorder (PTSD). An estimated one-third of patients with cancer develop symptoms of PTSD at some point in their treatment. However, few studies have evaluated the contributions of PTSD and sleep disturbance to pain processes in cancer populations. The current study used mediation models to test the hypothesis that sleep disturbance would mediate the relationships between PTSD symptoms and pain intensity and PTSD symptoms and pain interference in a sample of patients with cancer.

Methods:

A cross-sectional, retrospective chart review was conducted of the electronic medical records of 85 adult patients with cancer (89.4% female; 59% white; 42% metastatic) who sought individual psychosocial support services at our institution.

Results:

Post-traumatic stress disorder symptoms, sleep disturbance, pain intensity, and pain interference were all positively correlated ( P < .01). Clinical levels of PTSD symptoms were reported by 30% to 60% of the sample. Even after controlling for metastatic disease, race, and cancer type, sleep disturbance mediated the relationships between PTSD symptoms and pain intensity ( B = 0.27; 95% CI: 0.10-0.44) and PTSD symptoms and pain-related interference ( B = 0.58; 95% CI: 0.28-0.87).

Conclusions:

The relationships among PTSD symptoms, pain intensity, and pain interference could be explained by co-occurring sleep disturbance. Given the high frequency of PTSD symptoms among patients with cancer and PTSD’s known links to sleep problems and pain, clinicians should be attentive to the role that traumatogenic processes may play in eliciting sleep and pain-related complaints among patients with cancer.
Population Shifts and Discrete Public Services: Rationing Rules and the Support for Public Goods
Authors: Cherry Todd L. , Cotten Stephen J. , McKee Michael
Published: October 2017

Cities with declining populations face increasing per-capita costs to maintain discrete public goods—those with fixed costs that cannot be easily scaled to demand. Likewise, growing cities may face decreasing benefits from congestible public goods. In either case, there are two policy actions: limit access (ration) or expand output (higher revenues per person required). We report the results of a series of experiments designed to investigate the effect of alternative rationing rules on the propensity for individuals to support increases in taxes to overcome congestion externalities or decreases in the tax base.
Successful Surgical Resection of Iatrogenic Antecubital Venous Pseudoaneurysm Following Venipuncture: A 2-Case Report
Authors: Niimi Yosuke , Yamaki Takashi , Hori Kejiro , Kirita Miho , Nagashima Yoji , Sakurai Hiroyuki
Published: October 2017

Iatrogenic venous pseudoaneurysm (VP) formation after venipuncture is rare. This report showed 2 cases of VP following venipuncture, and VPs were resected surgically. A 58-year-old woman and a 56-year-old woman developed a soft antecubital mass after blood sampling from the basilic veins. One patient had the sensory disturbance of forearm. The mass was diagnosed as a VP with thrombus by duplex ultrasound and magnetic resonance imaging. The aneurysm was resected completely, and the sensory disturbance of the patient was improved. Surgical resection was the most appropriate treatment for the relief of symptoms due to compression.
Evaluation of synchronizer loading parameters and their ability to predict failure
Authors: Häggström Daniel , Sellgren Ulf , Björklund Stefan
Published: October 2017

Molybdenum coated gearbox synchronizers are tested in a μ-comp test rig under varying loading conditions until failure. Four different parameters used to describe the thermomechanical load are evaluated just before failure to compare their ability to predict failure. The parameters evaluated are the synchronized kinetic energy, the synchronization power, and the focal as well as the average surface temperature increase. The focal surface temperature increase as well as the average surface temperature increase is found to predict failure with relatively good accuracy. It is shown that there exists a threshold which divides the synchronizer into either a very long or a very short service life. Additionally, a method to determine the average surface temperature in the gearbox management system is proposed.
Performance of lubricating oils for wind turbine gear boxes and bearings
Authors: Burkhart Christoph , Johansson Jens , Ukonsaari Jan , Prakash Braham
Published: October 2017

In this study, the friction and wear properties of six different new and used wind turbine gear oils (ISO VG 320), with different base oil formulations and additives packages, were investigated. For that purpose, a four-ball tribometer and an Optimol SRV were used. Moreover, the lubricants extreme pressure properties were also evaluated, using the same four-ball tribometer. The study also includes a characterization of the lubricants. The main objective was to compare the new and used gear oils in order to identify performance differences and predict oil change intervals. The results indicate that a use of 3 to 4 years is within the lifetime of the lubricant.
Prediction of the acoustic shielding by aircraft empennage for contra-rotating open rotors
Authors: Sanders L , Mincu D-C , Vitagliano PL , Minervino M , Kennedy J , Bennett G
Published: October 2017

This paper presents a numerical study of the acoustic shielding of aeroengine noise by the aircraft structure. More specifically, the engines considered are contra-rotating open rotors in pusher mode which are installed at the rear of the aircraft. Several empennage designs and engine positions are evaluated. An original method for the calculation of engine noise installation effects is presented and its application to contra-rotating open rotor propulsion is demonstrated. It is based on the weak coupling between computational fluid dynamics, an integral method based on Lighthill’s analogy for the calculation of acoustic radiation, and on a boundary element method for the calculation of the acoustic diffraction by the aircraft fuselage and empennage. The prediction of a pylon-installed (isolated) contra-rotating open rotor noise directivity is presented and compared to equivalent wind-tunnel measurements. In both cases, the simulation and experiment are performed at 1:7 scale. In addition, the installation effect of the wind-tunnel, being non-anechoic, is also assessed with the numerical approach presented. Finally, for each aircraft configuration of interest, equipped with two rear contra-rotating open rotors, the predicted noise impact on the ground is evaluated. Of these, the contra-rotating open rotor mounted above an L-tail empennage is found to be the most beneficial configuration in terms of acoustic shielding.
Exploring Early Exits: Doctoral Attrition in the Biomedical Sciences
Authors: Maher Michelle A. , Wofford Annie M. , Roksa Josipa , Feldon David F.
Published: October 2017

High attrition rates have been a defining characteristic of doctoral education for decades, representing a loss of time, talent, and effort for departing students and their faculty. This qualitative study uses a biomedical science doctoral student sample to collect “real time” data on attrition within the first 2 years of doctoral training. Eighteen students, who represented 16 distinct universities, were interviewed as they engaged in the withdrawal process. Using the conceptual frames of socialization and social cognitive career theory, we explored experiences that preceded these students’ doctoral program withdrawals. Furthermore, we examined how expressed roles of students’ self-efficacy, outcome expectations, and professional goals contributed to the withdrawal process. Findings indicate that faculty advising (both positive and negative), laboratory rotation experiences, self-efficacy components, and changing professional goals all play a role in the early doctoral program attrition process.
Microarray analysis to identify the similarities and differences of pathogenesis between aortic occlusive disease and abdominal aortic aneurysm
Authors: Wang Guofu , Bi Lechang , Wang Gaofeng , Huang Feilai , Lu Mingjing , Zhu Kai
Published: October 2017

Objectives

Expression profile of GSE57691 was analyzed to identify the similarities and differences between aortic occlusive disease and abdominal aortic aneurysm.

Methods

The expression profile of GSE57691 was downloaded from Gene Expression Omnibus database, including 20 small abdominal aortic aneurysm samples, 29 large abdominal aortic aneurysm samples, 9 aortic occlusive disease samples, and 10 control samples. Using the limma package in R, the differentially expressed genes were screened. Followed by enrichment analysis was performed for the differentially expressed genes using database for annotation, visualization, and integrated discovery online tool. Based on string online tool and Cytoscape software, protein–protein interaction network and module analyses were carried out. Moreover, integrated TF platform database and Cytoscape software were used for constructing transcriptional regulatory networks.

Results

As a result, 1757, 354, and 396 differentially expressed genes separately were identified in aortic occlusive disease, large abdominal aortic aneurysm, and small abdominal aortic aneurysm samples. UBB was significantly enriched in proteolysis related pathways with a high degree in three groups. SPARCL1 was another gene shared by these groups and regulated by NFIA, which had a high degree in transcriptional regulatory network. ACTB, a significant upregulated gene in abdominal aortic aneurysm samples, could be regulated by CLIC4, which was significantly enriched in cell motions. ACLY and NFIB were separately identified in aortic occlusive disease and small abdominal aortic aneurysm samples, and separately enriched in lipid metabolism and negative regulation of cell proliferation.

Conclusions

The downregulated UBB, NFIA, and SPARCL1 might play key roles in both aortic occlusive disease and abdominal aortic aneurysm, while the upregulated ACTB might only involve in abdominal aortic aneurysm. ACLY and NFIB were specifically involved in aortic occlusive disease and small abdominal aortic aneurysm separately.
Anti-inflammatory activity of a thermophilic serine protease inhibitor from extremophile Pyrobaculum neutrophilum
Authors: Fei Rui , Zhang Huan , Zhong Sheng , Xue Baigong , Gao Yuanqi , Zhou Xiaoli
Published: October 2017

Serine protease inhibitors (serpins) are a superfamily of proteins involved in many important biological processes, including inflammation. Serpins dysfunction-related diseases are mainly treated by augmentation therapy using serpins purified from human plasma. Pnserpin from hyperthermophilic archaeon Pyrobaculum neutrophilum showed protease inhibition activity and high stability. In this study, we examined the anti-inflammatory activity of Pnserpin using xylene-induced acute inflammatory model of mouse ear swelling and lipopolysaccharide (LPS)-induced murine RAW 264.7 macrophages cellular model. The inhibition of mouse ear swelling and the production of pro-inflammatory cytokines in mouse serum or in macrophages cell were used to evaluate the anti-inflammatory effect of Pnserpin. Our results showed that Pnserpin could inhibit the xylene-induced mouse ear swelling and suppress the production of pro-inflammatory cytokines in mouse serum and in LPS-induced RAW264.7 cells. This study indicated that Pnserpin might have anti-inflammatory effect in vivo and in vitro.
Braintree v. Breckenridge and the potential danger of stipulation to a claim construction from an earlier case
Authors: Rein Frederick H , Zalcenstein Aviv A , Mueller Kenneth L
Published: October 2017

Stipulating to be bound by an earlier claim construction decision has many advantages: it streamlines the case, saves time and money on litigation costs, and allows parties to focus their arguments on real areas of disagreement. However, sometimes parties that are looking for clarity will stipulate to an earlier claim construction, only to discover that an unforeseen consequence of that construction is fatal to their case. One pharmaceutical company learned this lesson the hard way, when it stipulated to be bound by a construction rendered in an earlier case involving a different defendant. The Federal Circuit ruled that the earlier construction had implications for a term not explicitly construed in the earlier case, thus defeating a non-infringement argument predicated on a new construction for that term.
Public value tensions for Dutch DSOs in times of energy transition
Authors: Edens Marga
Published: October 2017

This article centres around two concepts: public values and regulatory disconnection. It provides a study of the potential tensions Dutch distribution system operators (DSOs) encounter in their role as safeguarders of energy sector public values. The article elaborates how these public values tensions can be traced back to current energy sector legislation not being able to keep up with the energy transition. DSOs have the statutory task of safeguarding public values (understood as ‘properties of utility services’), such as availability, affordability and safety. They are expected to safeguard these public values in such a way that a certain balance between them is maintained. Based on interviews with Dutch sector representatives and an expert panel survey, we show that DSOs do strive for a balance between public values, but that the energy transition makes achieving it more difficult. Three cases were selected where DSOs apparently struggle. We find that the energy sector legislation DSOs have to comply with in these cases does not always account for the impact of the energy transition, thus constituting a regulatory disconnection. The discrepancy between the legislator’s and DSO’s intentions and the DSO’s daily practice would suggest additional research into mechanisms that may facilitate DSOs in conducting a more explicit trade-off, which would produce a public value treatment that is sustainable in terms of social acceptance. This would help secure the energy transition its much needed public support.
Motivations and Experiences of Canadians Seeking Treatment for Lyme Disease Outside of the Conventional Canadian Health-Care System
Authors: Boudreau Corinne R , Lloyd Vett K , Gould Odette N
Published: October 2017

Objective:

We aimed to describe the experiences of Canadians who seek diagnosis and treatment for Lyme disease outside of the conventional Canadian health-care system.

Methods:

Forty-five individuals who had sought treatment for Lyme disease outside of the conventional Canadian health-care system were recruited from Lyme support and advocacy groups across Canada to answer open-ended questions about their experiences.

Results:

Respondents sought treatment outside of the conventional medical system due to extensive diagnostic procedures and treatments that did not resolve symptoms. Escalating health concerns, lack of effective treatment, and stigma produced a sense of abandonment and desperation. Respondents accessed alternative forms of care based on the recommendations of peers, yet considerable financial and emotional stress was experienced.

Conclusions:

Many individuals with Lyme or Lyme-like diseases are deeply dissatisfied with the care received within the conventional Canadian health-care system and therefore felt both pushed and pulled to seek treatments either from international physicians using different treatment protocols or from alternative medicine providers in Canada.
VLITL is a major cross-β-sheet signal for fibrinogen Aα-chain frameshift variants
Authors: Garnier Cyrille , Briki Fatma , Nedelec Brigitte , Le Pogamp Patrick , Dogan Ahmet , Rioux-Leclercq Nathalie , Goude Renan , Beugnet Caroline , Martin Laurent , Delpech Marc , Bridoux Frank , Grateau Gilles , Doucet Jean , Derreumaux Philippe , Valleix Sophie
Published: October 2017

Key Points

VLITL is amyloid prone and forms the ends of Aα-chain fibrils in vivo. VLITL explains the molecular basis of Aα-chain amyloidogenesis.
Charlotte Perkins Gilman’s Novel Aesthetics
Authors: Fisher Laura R.
Published: October 2017

Charlotte Perkins Gilman’s novels and short stories are notably didactic, but they are not merely socioeconomic treatises in disguise. Her unabashedly mundane and pedantic literary style embodies a self-consciously modern aesthetics of didacticism that pervaded US literature in its years of transition between realism, naturalism, and modernism and that characterized the subgenre of sociological fiction. Gilman’s 1910 novel What Diantha Did models the social rigor that sociological novelists considered essential to the art of fiction. What Diantha Did tracks the creation of a system of kitchenless homes in California and the subsequent emancipation of women from forced domesticity. Gilman’s prose reflects on, and even formally replicates, the drudgery and repetition she associates with household labor. Gilman proposes an analogy between novels and kitchens as genres of modern social life: both must be collectivized and liberated from the archaic, the personal, and the masculine.
The Impossible Miss Woolf: Kate Atkinson and the Feminist Modernist Historical Novel
Authors: Micir Melanie
Published: October 2017

Reading Kate Atkinson’s Life after Life (2013) in the context of theories of the historical novel (Georg Lukács, Fredric Jameson) and counterfactual fiction (Catherine Gallagher, Andrew Miller, Paul Saint-Amour) sheds light on an overlooked genealogy of the feminist modernist historical novel. Atkinson’s novels are often cited as examples of postmodern metafiction, but in fact her work is more directly indebted to modernist experiments in counterfactual historical writing by figures like Virginia Woolf. Moreover, this inheritance, inasmuch as it informs Atkinson’s focus on the untold lives of ordinary women, is not only modernist but feminist.
Putting Messianic Femininity into Zionist Political Action
Authors: Feldman Rachel Z.
Published: October 2017

The movement to rebuild the Third Jewish Temple on the Temple Mount/Haram ash-Sharif in Jerusalem has grown significantly since 2000. The Orthodox Jewish “Women for the Temple” group has come to play a central role in this activism. Women for the Temple activists perform a messianic femininity that emphasizes maternal duties and women’s redemptive power in Judaism while challenging male religious authorities and religious law in other areas. Activists define themselves as guardians of domestic space and the House of God (the future Third Temple) and redeemers of the Jewish nation. This project simultaneously empowers women and enables state violence against Palestinians on Haram ash-Sharif. Scholarship that has examined Israel’s messianic right-wing women’s activism has overlooked their Ashkenazi whiteness and their middle-class privileged status in Israel. The race-class normativity of Women for the Temple allows them to access resources and police protection and facilitates the mainstreaming of the Third Temple movement.
Molybdenum Adsorption Properties of Alumina-Embedded Mesoporous Silica for Medical Radioisotope Production
Authors: Saptiama Indra , Kaneti Yusuf Valentino , Oveisi Hamid , Suzuki Yoshitaka , Tsuchiya Kunihiko , Takai Kimiko , Sakae Takeji , Pradhan Subrata , Hossain Md Shahriar A , Fukumitsu Nobuyoshi , Ariga Katsuhiko , Yamauchi Yusuke
Published: October 2017

In this work, we have prepared alumina-embedded mesoporous silica and investigated their molybdenum (Mo) adsorption properties. To synthesize such materials, mesoporous silica particles were firstly synthesized via a soft-templated approach followed by the introduction of aluminium butoxide into the mesopores, which was converted into alumina by heat treatment at high temperatures. The obtained alumina-embedded mesoporous silica samples (Alx-MPS) were characterized by low- and wide-angle X-ray diffractions, nitrogen adsorption-desorption isotherms, and transmission electron microscopy. The effects of Al/Si ratios and calcination temperature on their Mo adsorption properties were also carefully investigated by using the batch method. The experimental results showed the following trend in Mo adsorption capacity in relation to the calcination temperature: 750 °C > 600 °C > 900 °C > 1050 °C and Al/Si molar ratio: Al0.1-MPS < Al0.3-MPS < Al0.5-MPS < Al0.6-MPS.