bluuebunny/crossref_metadata_2025 huggingface dataset:
Author Correction: Phosphoinositide 3-Kinase (PI3K) Subunit p110δ Is Essential for Trophoblast Cell Differentiation and Placental Development in Mouse
Authors: Hu Xiwen , Li Jiangchao , Zhang Qianqian , Zheng Lingyun , Wang Guang , Zhang Xiaohan , Zhang Jingli , Gu Quliang , Ye Yuxiang , Guo Sun-Wei , Yang Xuesong , Wang Lijing
Published: April 2020

A correction has been published and is appended to both the HTML and PDF versions of this paper. The error has not been fixed in the paper.
Author Correction: Formation of gold nanoparticles by glycolipids of Lactobacillus casei
Authors: Kikuchi Fumiya , Kato Yugo , Furihata Kazuo , Kogure Toshihiro , Imura Yuki , Yoshimura Etsuro , Suzuki Michio
Published: April 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Author Correction: Neuroprotective pentapeptide CN-105 improves functional and histological outcomes in a murine model of intracerebral hemorrhage
Authors: Lei Beilei , James Michael L. , Liu Ji , Zhou Guanen , Venkatraman Talaignair N. , Lascola Christopher D. , Acheson Shawn K. , Dubois Laura G. , Laskowitz Daniel T. , Wang Haichen
Published: April 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Effect of excessive gestational weight on daughters’ breast density at the end of puberty onset
Authors: López Ana , Garmendia María Luisa , Shepherd John , Michels Karin , Corvalán Camila , Pereira Ana
Published: April 2020

The effect of excessive gestational weight gain (EGWG) is related to adverse health outcomes in the offspring; however, its effect on the daughters’ breast density is unclear. We aimed to assess the association between EGWG and daughters’ breast composition (% of fibroglandular volume (%FGV) and absolute fibroglandular volume (AFGV)) at Tanner stage 4 (Tanner B4)). We included 341 girls and their mothers from an ongoing cohort of low-income Chilean girls born from 2002–2003. Maternal gestational weight gain was self-reported in 2007, and breast density by digital mammography was measured in 2010. Weight, height and breast composition by dual X-ray absorptiometry (DXA) were measured in daughters at Tanner B4. Logistic regression models were run to assess the association between EGWG and the 80th percentile of %FGV and AFGV. Mean gestational weight gain was 13.7 kg (SD = 6.9 kg). Women with pregestational overweight or obesity exceeded the recommended gestational weight gain (58.8% vs. 31.8%, respectively). Daughters of women who had EGWG had higher levels of AFGV (OR: 2.02; 95%CI 1.16–3.53) at Tanner B4, which could be explained by metabolic and hormonal exposure in utero. However, we did not observe an association with %FGV.
Extensive transcriptome changes during seasonal leaf senescence in field-grown black cottonwood (Populus trichocarpa Nisqually-1)
Authors: Lu Haiwei , Gordon Michael I. , Amarasinghe Vindhya , Strauss Steven H.
Published: April 2020

To better understand the molecular control of leaf senescence, we examined transcriptome changes during seasonal leaf senescence in Populus trichocarpa Nisqually-1, the Populus reference genome, growing in its natural habitat. Using monthly (from May to October) transcriptomes for three years (2009, 2015, and 2016), we identified 17,974 differentially expressed genes (DEGs; false discovery rate <0.05; log-fold change cutoff = 0) from 36,007 expressed Populus gene models. A total of 14,415 DEGs were directly related to transitions between four major developmental phases – growth, senescence initiation, reorganization, and senescence termination. These DEGs were significantly (p < 0.05) enriched in 279 gene ontology (GO) terms, including those related to photosynthesis, metabolic process, catalytic activity, protein phosphorylation, kinase activity, pollination, and transport. Also, there were 881 differentially expressed transcription factor (TF) genes from 54 TF families, notably bHLH, MYB, ERF, MYB-related, NAC, and WRKY. We also examined 28 DEGs known as alternative splicing (AS) factors that regulate AS process, and found evidence for a reduced level of AS activity during leaf senescence. Furthermore, we were able to identify a number of promoter sequence motifs associated with leaf senescence. This work provides a comprehensive resource for identification of genes involved in seasonal leaf senescence in trees, and informs efforts to explore the conservation and divergence of molecular mechanisms underlying leaf senescence between annual and perennial species.
Design and efficient synthesis of pyrazoline and isoxazole bridged indole C-glycoside hybrids as potential anticancer agents
Authors: Kumari Priti , Mishra Vishnu S. , Narayana Chintam , Khanna Ashish , Chakrabarty Anindita , Sagar Ram
Published: April 2020

C-glycosides are important class of molecules exhibit diverse biological activities and present as structural motif in many natural products. Two series of new pyrazoline and isoxazole bridged indoleC-glycoside molecular hybrids (n = 36) were efficiently synthesized starting from diverse indole 3-carboxaldehydes derived α, β-unsaturated ketone derivatives of β-D-glucosyl-propan-2-one, β-D-galactosyl-propan-2-one and β-D-mannosyl-propan-2-one, reacting with hydrazine hydrate and hydroxyl amine hydrochloride in shorter reaction time (15 min) under microwave assisted condition. Anticancer activity of these newly synthesized pyrazoline and isoxazole bridged indolesC-glycoside hybrids were determined in details through cellular assays against MCF-7, MDA-MB-453 and MDA-MB-231 cancer cell lines. The selected library members displayed low micromolar (IC50 = 0.67–4.67 µM) and selective toxicity against breast cancer cell line (MCF-7). Whereas these compounds were nontoxic towards normal cell line (MCF-10A). Mechanistic studies showed that, active compounds inhibit COX-2 enzyme, which was also supported by molecular docking studies. These findings are expected to provide new leads towards anticancer drug discovery.
Hers and his: Silk glands used in egg sac construction by female spiders potentially repurposed by a ‘modern’ male spider
Authors: Townley Mark A. , Harms Danilo
Published: April 2020

Cylindrical silk gland (CY) spigots distinguish a large clade of modern spiders, the CY spigot clade, which includes all entelegyne spiders and their closest relatives. Following a widespread paradigm, CYs and their spigots are only known to occur in female spiders and they produce silk used in the construction of egg sacs. Here we report the occurrence of a CY spigot or CY nubbin on each posterior median spinneret (PMS) in males (5th stadium and later) of the spider Australomimetus maculosus. Late juvenile males had a CY spigot on each PMS, whereas adult males either had a CY spigot or, more often, a non-functional CY nubbin. This indicates that potential CY use by males is at least largely limited to late juvenile instars and is not involved with egg sac construction. Despite the presence of CY spigots in both sexes, sexual dimorphism with respect to CYs was still evident since males lacked the CY spigot on each posterior lateral spinneret present in late juvenile and adult females, and CY spigots of males never had the wide shaft and opening of adult females. This study adds to our knowledge of spinning apparatus variability in modern spiders and demonstrates an exception to the paradigm that, in the CY spigot clade, such spigots are restricted to female spiders.
NusA directly interacts with antitermination factor Q from phage λ
Authors: Dudenhoeffer Benjamin R. , Borggraefe Jan , Schweimer Kristian , Knauer Stefan H.
Published: April 2020

Antitermination (AT) is a ubiquitous principle in the regulation of bacterial transcription to suppress termination signals. In phage λ antiterminator protein Q controls the expression of the phage’s late genes with loading of λQ onto the transcription elongation complex halted at a σ-dependent pause requiring a specific DNA element. The molecular basis of λQ-dependent AT and its dependence on N-utilization substance (Nus) A is so far only poorly understood. Here we used solution-state nuclear magnetic resonance spectroscopy to show that the solution structure of λQ is in agreement with the crystal structure of an N-terminally truncated variant and that the 60 residues at the N-terminus are unstructured. We also provide evidence that multidomain protein NusA interacts directly with λQ via its N-terminal domain (NTD) and the acidic repeat (AR) 2 domain, with the λQ:NusA-AR2 interaction being able to release NusA autoinhibition. The binding sites for NusA-NTD and NusA-AR2 on λQ overlap and the interactions are mutually exclusive with similar affinities, suggesting distinct roles during λQ-dependent AT, e.g. the λQ:NusA-NTD interaction might position NusA-NTD in a way to suppress termination, making NusA-NTD repositioning a general scheme in AT mechanisms.
Synchrotron-based high-resolution photoemission spectroscopy study of ZIRLO cladding with H2O adsorption: Coverage and temperature dependence
Authors: Park Sangjune , Kim Ki-jeong , Lee Jeongmook , Kim Jong-Yun , Lee Dong Woo , Lim Sang Ho , Youn Young-Sang
Published: April 2020

The coverage and temperature dependence of ZIRLO cladding with H2O adsorption are studied using synchrotron-based high-resolution photoemission spectroscopy (HRPES). Based on the analytical results of the Zr 3d, O 1 s, C 1 s, and Sn 3d HRPES profiles prior to H2O adsorption, we determine the surface compositions of O2−, hydroxyl OH−, chemisorbed H2O, zirconium carbide, adventitious carbon, Sn metal, and SnO2 in ZIRLO. When ZIRLO is exposed to H2O molecules, the relative proportion of zirconium metal decreases, whereas that of the total zirconium oxides increases, suggesting the reaction between H2O and the zirconium metal in ZIRLO. On annealing a sample with 1000 L H2O on ZIRLO at 300 °C, Zr2O3 and ZrO2 decompose, and oxygen diffuses into the bulk, thereby reducing the oxidation states of zirconium on the surface. Moreover, at this temperature, the excess H2O molecules on ZIRLO are thoroughly desorbed and tin element is diffused into the bulk in ZIRLO.
Development of a quantitative, portable, and automated fluorescent blue-ray device-based malaria diagnostic equipment with an on-disc SiO2 nanofiber filter
Authors: Yamamoto Takeki , Hashimoto Muneaki , Nagatomi Kenji , Nogami Takahiro , Sofue Yasuyuki , Hayashi Takuya , Ido Yusuke , Yatsushiro Shouki , Abe Kaori , Kajimoto Kazuaki , Tamari Noriko , Awuor Beatrice , Sonye George , Kongere James , Munga Stephen , Ohashi Jun , Oka Hiroaki , Minakawa Noboru , Kataoka Masatoshi , Mita Toshihiro
Published: April 2020

There is an urgent need to develop an automated malaria diagnostic system that can easily and rapidly detect malaria parasites and determine the proportion of malaria-infected erythrocytes in the clinical blood samples. In this study, we developed a quantitative, mobile, and fully automated malaria diagnostic system equipped with an on-disc SiO2 nanofiber filter and blue-ray devices. The filter removes the leukocytes and platelets from the blood samples, which interfere with the accurate detection of malaria by the blue-ray devices. We confirmed that the filter, which can be operated automatically by centrifugal force due to the rotation of the disc, achieved a high removal rate of leukocytes (99.7%) and platelets (90.2%) in just 30 s. The automated system exhibited a higher sensitivity (100%) and specificity (92.8%) for detecting Plasmodium falciparum from the blood of 274 asymptomatic individuals in Kenya when compared to the common rapid diagnosis test (sensitivity = 98.1% and specificity = 54.8%). This indicated that this system can be a potential alternative to conventional methods used at local health facilities, which lack basic infrastructure.
Hemocyte phagosomal proteome is dynamically shaped by cytoskeleton remodeling and interorganellar communication with endoplasmic reticulum during phagocytosis in a marine invertebrate, Crassostrea gigas
Authors: Mao Fan , Mu Huawei , Wong Nai-Kei , Liu Kunna , Song Jingchen , Qiu Jianwen , Lin Yue , Zhang Xiangyu , Xu Duo , Xiang Zhiming , Li Jun , Zhang Yang , Yu Ziniu
Published: April 2020

Phagosomes are task-force organelles of innate immune systems, and evolutionary diversity and continuity abound in the protein machinery executing this coordinately regulated process. In order to clarify molecular mechanisms underlying phagocytosis, we studied phagocyte response to beads and Vibrio species, using hemocytes of the Pacific oysters (Crassostrea gigas) as a marine invertebrate model. Phagosomes from different stages of phagocytosis were isolated by density-gradient centrifugation, and more than 400 phagosome-associated proteins were subsequently identified via high-throughput quantitative proteomics. In modeling key networks of phagosomal proteins, our results support the essential roles of several processes driving phagosome formation and maturation, including cytoskeleton remodeling and signal transduction by Rab proteins. Several endoplasmic reticulum (ER)-associated proteins were identified, while live cell imaging confirms an apparent intimate interaction between the ER and phagosomes. In further quantitative proteomic analysis, the signal transducers CgRhoGDI and CgPI4K were implicated. Through experimental validation, CgRhoGDI was shown to negatively regulate actin cytoskeleton remodeling in the formation of oyster phagosomes, while CgPI4K signaling drives phagosome maturation and bacterial killing. Our current work illustrates the diversity and dynamic interplay of phagosomal proteins, providing a framework for better understanding host-microbe interactions during phagosome activities in under-examined invertebrate species.
S-Phase Kinase-associated Protein-2 Rejuvenates Senescent Endothelial Progenitor Cells and Induces Angiogenesis in Vivo
Authors: Wang Hsueh-Hsiao , Lee Yi-Nan , Su Cheng-Huang , Shu Kuo-Tung , Liu Wen-Ting , Hsieh Chin-Ling , Yeh Hung-I , Wu Yih-Jer
Published: April 2020

Cell cycle slowdown or arrest is a prominent feature of cellular senescence. S-phase kinase-associated protein-2 (Skp2), an F-box subunit of SCFSkp2 ubiquitin ligase, is a key regulator of G1/S transition. We investigated whether Skp2 plays a role in the regulation of endothelial progenitor cell (EPC) senescence, which is closely associated with aging-related vasculopathy. Replication-induced senescent EPCs demonstrated more pronounced senescence markers and lower Skp2 levels in comparison with those of their younger counterparts. Depletion of Skp2 induced increases in senescence-associated β-galactosidase (SA-βGal) activity and a reduction of telomere length and generated a senescent bioenergetics profile, whereas adenoviral-mediated Skp2 expression reversed the relevant senescence. EPCs isolated from older rats displayed a reduced proliferation rate and increased SA-βGal activity, both of which were significantly reversed by Skp2 ectopic expression. In addition to reversing senescence, Skp2 also rescued the angiogenic activity of senescent EPCs in the ischemic hind limbs of nude mice. The results revealed that ectopic expression of Skp2 has the potential to rejuvenate senescent EPCs and rescue their angiogenic activity and thus may be pivotal in the development of novel strategies to manage aging-related vascular disease.
Author Correction: Flotillin-2 promotes metastasis of nasopharyngeal carcinoma by activating NF-κB and PI3K/Akt3 signaling pathways
Authors: Liu Jie , Huang Wei , Ren Caiping , Wen Qiuyuan , Liu Weidong , Yang Xuyu , Wang Lei , Zhu Bin , Zeng Liang , Feng Xiangling , Zhang Chang , Chen Huan , Jia Wei , Zhang Lihua , Xia Xiaomeng , Chen Yuxiang
Published: April 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Author Correction: Menopause-induced uterine epithelium atrophy results from arachidonic acid/prostaglandin E2 axis inhibition-mediated autophagic cell death
Authors: Zhou Shengtao , Zhao Linjie , Yi Tao , Wei Yuquan , Zhao Xia
Published: April 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Author Correction: Changes in mitochondrial homeostasis and redox status in astronauts following long stays in space
Authors: Indo Hiroko P. , Majima Hideyuki J. , Terada Masahiro , Suenaga Shigeaki , Tomita Kazuo , Higashibata Akira , Ishioka Noriaki , Kanekura Takuro , Hawkins Clare L. , Davies Michael J. , St Clair Daret K. , Mukai Chiaki
Published: April 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
An intact C-terminal end of albumin is required for its long half-life in humans
Authors: Nilsen Jeannette , Trabjerg Esben , Grevys Algirdas , Azevedo Claudia , Brennan Stephen O. , Stensland Maria , Wilson John , Sand Kine Marita Knudsen , Bern Malin , Dalhus Bjørn , Roopenian Derry C. , Sandlie Inger , Rand Kasper Dyrberg , Andersen Jan Terje
Published: April 2020

Albumin has an average plasma half-life of three weeks and is thus an attractive carrier to improve the pharmacokinetics of fused therapeutics. The half-life is regulated by FcRn, a cellular receptor that protects against intracellular degradation. To tailor-design the therapeutic use of albumin, it is crucial to understand how structural alterations in albumin affect FcRn binding and transport properties. In the blood, the last C-terminal residue (L585) of albumin may be enzymatically cleaved. Here we demonstrate that removal of the L585 residue causes structural stabilization in regions of the principal FcRn binding domain and reduces receptor binding. In line with this, a short half-life of only 3.5 days was measured for cleaved albumin lacking L585 in a patient with acute pancreatitis. Thus, we reveal the structural requirement of an intact C-terminal end of albumin for a long plasma half-life, which has implications for design of albumin-based therapeutics.
Domain sliding of two Staphylococcus aureus N-acetylglucosaminidases enables their substrate-binding prior to its catalysis
Authors: Pintar Sara , Borišek Jure , Usenik Aleksandra , Perdih Andrej , Turk Dušan
Published: April 2020

To achieve productive binding, enzymes and substrates must align their geometries to complement each other along an entire substrate binding site, which may require enzyme flexibility. In pursuit of novel drug targets for the human pathogenS. aureus, we studied peptidoglycan N-acetylglucosaminidases, whose structures are composed of two domains forming a V-shaped active site cleft. Combined insights from crystal structures supported by site-directed mutagenesis, modeling, and molecular dynamics enabled us to elucidate the substrate binding mechanism of SagB and AtlA-gl. This mechanism requires domain sliding from the open form observed in their crystal structures, leading to polysaccharide substrate binding in the closed form, which can enzymatically process the bound substrate. We suggest that these two hydrolases must exhibit unusual extents of flexibility to cleave the rigid structure of a bacterial cell wall.
Genome-wide association study of Buruli ulcer in rural Benin highlights role of two LncRNAs and the autophagy pathway
Authors: Manry Jeremy , Vincent Quentin B. , Johnson Christian , Chrabieh Maya , Lorenzo Lazaro , Theodorou Ioannis , Ardant Marie-Françoise , Marion Estelle , Chauty Annick , Marsollier Laurent , Abel Laurent , Alcaïs Alexandre
Published: April 2020

Buruli ulcer, caused byMycobacterium ulceransand characterized by devastating necrotizing skin lesions, is the third mycobacterial disease worldwide. The role of host genetics in susceptibility to Buruli ulcer has long been suggested. We conduct the first genome-wide association study of Buruli ulcer on a sample of 1524 well characterized patients and controls from rural Benin. Two-stage analyses identify two variants located within LncRNA genes: rs9814705 inENSG00000240095.1(P = 2.85 × 10−7; odds ratio = 1.80 [1.43–2.27]), and rs76647377 inLINC01622(P = 9.85 × 10−8; hazard ratio = 0.41 [0.28–0.60]). Furthermore, we replicate the protective effect of allele G of a missense variant located inATG16L1, previously shown to decrease bacterial autophagy (rs2241880,P = 0.003; odds ratio = 0.31 [0.14–0.68]). Our results suggest LncRNAs and the autophagy pathway as critical factors in the development of Buruli ulcer.
A one-step rapid synthesis of TS-1 zeolites with highly catalytically active mononuclear TiO6species
Authors: Xu Wenjing , Zhang Tianjun , Bai Risheng , Zhang Peng , Yu Jihong
Published: April 2020

The modulation and determination of the coordination environments of Ti active sites in titanosilicate zeolites are key challenges in the rational design of high-performance heterogeneous catalysts.
Nano-scale control of the ionomer distribution by molecular masking of the Pt surface in PEMFCs
Authors: Doo Gisu , Yuk Seongmin , Lee Ji Hye , Choi Sungyu , Lee Dong-Hyun , Lee Dong Wook , Hyun Jonghyun , Kwon Sung Hyun , Lee Seung Geol , Kim Hee-Tak
Published: April 2020

A new strategy for controlling the ionomer distribution in the catalyst layer of a polymer electrolyte membrane fuel cell, the molecular masking of Pt catalyst particles, is presented to achieve efficient three phase boundaries for the ORR.
Rotation-restricted thermally activated delayed fluorescence compounds for efficient solution-processed OLEDs with EQEs of up to 24.3% and small roll-off
Authors: Li Kuofei , Zhu Yunhui , Yao Bing , Chen Yuannan , Deng Hao , Zhang Qisheng , Zhan Hongmei , Xie Zhiyuan , Cheng Yanxiang
Published: April 2020

A sandwich-like chromophore, composed of two donors and an inserted acceptor, is hitched onto a single carbazole to yield an efficient TADF emitter with excellent electroluminescent performance.
Non-classical crystal growth on a hydrophobic substrate: learning from bivalve nacre
Authors: Feng Xin , Gao Ruohe , Wang Rize , Zhang Gangsheng
Published: April 2020

The hydrophobic substrate has an effect on the non-classical crystallization of nacreous aragonite crystals.
Controlling the nucleation process of InP/ZnS quantum dots using zeolite as a nucleation site
Authors: Zhou Xiaopeng , Ren Jiejun , Dong Xuan , Wang Xicheng , Seto Takatoshi , Wang Yuhua
Published: April 2020

A novel synthesis strategy to adjust the emission wavelength of InP/ZnS quantum dots, using zeolite as a quantum dot nucleation template.
Substituent effects on the crystallization mechanisms of 7-chloro-4-substituted-quinolines
Authors: P. Copetti João P. , Salbego Paulo R. S. , Orlando Tainára , Rosa Jéssica M. L. , Fiss Gabriela F. , G. de Oliveira João P. , A. Vasconcellos Mário L. A. , Zanatta Nilo , G. Bonacorso Helio , Martins Marcos A. P.
Published: April 2020

The crystallization mechanisms of a series of fourteen 7-chloro-4-substituted-quinolines were proposed based on a retrocrystallization approach using the supramolecular cluster as demarcation.
Architecting layered molecular packing in substituted benzobisbenzothiophene (BBBT) semiconductor crystals
Authors: Higashino Toshiki , Arai Shunto , Inoue Satoru , Tsuzuki Seiji , Shimoi Yukihiro , Horiuchi Sachio , Hasegawa Tatsuo , Azumi Reiko
Published: April 2020

The construction of layered molecular packing structures in a non-layered crystalline material, benzobisbenzothiophene (BBBT), was achieved by employing long-alkyl and phenyl substituents, leading to high-performance organic thin-film transistors.
Achievement of enhanced solubility and improved optics in molecular complexes based on a sulfonate–pyridinium supramolecular synthon
Authors: Ahmad Ishtiyaq , Ganie Arshid A. , Dar Aijaz A.
Published: April 2020

Complexes 1–3 aggregate as intriguing supramolecular assemblies and show enhanced solubility and optical properties vis-à-vis pristine components. 3 exhibits striking enhancement in solubility of 2350% via-a-vis 4-A-3-HNSA-2H.
The joint effect of surface polarity and concentration on the structure and dynamics of acetonitrile solution: a molecular dynamics simulation study
Authors: Wang Yong-Peng , Ren Kezhou , Liu Shule
Published: April 2020

Representative orientations of water and ACN at different surface polarities.
Electronic properties and enhanced photocatalytic performance of van der Waals heterostructures of ZnO and Janus transition metal dichalcogenides
Authors: Idrees M. , Din H. U. , Rehman Shafiq Ur , Shafiq M. , Saeed Yasir , Bui H. D. , Nguyen Chuong V. , Amin Bin
Published: April 2020

Vertical stacking of two-dimensional materials into layered van der Waals heterostructures has recently been considered as a promising candidate for photocatalytic and optoelectronic devices because it can combine the advantages of the individual 2D materials.
Metallic nanostructures with low dimensionality for electrochemical water splitting
Authors: Li Leigang , Wang Pengtang , Shao Qi , Huang Xiaoqing
Published: April 2020

The recent advances in 1D and 2D metallic nanostructures for electrochemical water splitting (HER and OER) are highlighted.
Synthesis, sintering by Cool-SPS and characterization of A2Cu(CO3)2 (A = K, Na): evidence for multiferroic and magnetoelectric cupricarbonates
Authors: Herisson de Beauvoir Thomas , Sangregorio Anna , Cornu Iñaki , Josse Michaël
Published: April 2020

We report here the synthesis and densification of two magnetic materials in the system A2Cu(CO3)2 (A = Na, K).
Aluminium metal–insulator–metal structure fabricated by the bottom-up approach
Authors: Watanabe Rie , Mita Mai , Okamoto Takayuki , Isobe Toshihiro , Nakajima Akira , Matsushita Sachiko
Published: April 2020

Wide Al MIM nanostructures can be fabricated by bottom-up process.
Synthesis and herbicidal application of turpentine derivative p-menthene type secondary amines as sustainable agrochemicals
Authors: Dong Huanhuan , Xu Shichao , Wang Jing , Zhang Hongmei , Chen Yuxiang , Bi Liangwu , Zhao Zhendong
Published: April 2020

Compound 3a showed excellent herbicidal activity against barnyard grass with IC50 = 7.0 mg L−1, and exhibited good selection for rice, wheat, and radish at 100 mg L−1.
A magnetic ion-imprinted polymer composed of silica-coated magnetic nanoparticles and polymerized 4-vinyl pyridine and 2,6-diaminopyridine for selective extraction and determination of lead ions
Authors: Landarani Mohammad , Asgharinezhad Ali Akbar , Ebrahimzadeh Homeira
Published: April 2020

A novel, sensitive and highly selective magnetic ion-imprinted polymer for facile separation and preconcentration of trace quantities of Pb(ii) ions.
Organic–inorganic bimetallic hybrid particles with controllable morphology for the catalytic degradation of organic dyes
Authors: Mei Shuxing , Pan Mingwang , Gao Shenshen , Song Shaofeng , Wang Juan , Liu Gang
Published: April 2020

Amphiphilic bimetallic hybrid Janus nanoparticles with controllable morphology and ability to perform highly efficient catalytic degradation of organic dyes.
A “turn-on” fluorescent and colorimetric chemodosimeter for selective detection of Au3+ions in solution and in live cellsviaAu3+-induced hydrolysis of a rhodamine-derived Schiff base
Authors: Mondal Sanchita , Manna Saikat Kumar , Pathak Sudipta , Ghosh Aritri , Datta Pallab , Mandal Debasish , Mukhopadhyay Subrata
Published: April 2020

A chromogenic and “off–on” fluorogenic chemodosimeter (L) based on a naphthalene–rhodamine B derivative was designed, synthesized and characterized for the selective and sensitive detection of Au3+ions in mixed acetonitrile aqueous media.
4-Methyl-2,6-diformylphenol based biocompatible chemosensors for pH: discrimination between normal cells and cancer cells
Authors: Dhawa Tanumoy , Hazra Ananta , Barma Arpita , Pal Kunal , Karmakar Parimal , Roy Partha
Published: April 2020

Two 4-methyl-2,6-diformylphenol based compounds with pyridylamine have been established as chemosensors for pH. The probes are able to differentiate between normal cells and cancer cells.
Dual stimuli-responsive lanthanide-based phosphors for an advanced full-color anti-counterfeiting system
Authors: Wang Tianlin , Ji Xiangyi , Tao Zhanhui , Zhou Xiao , Hao Zhe , Wang Xinke , Gao Xia , Wang Shuo , Liu Yaqing
Published: April 2020

Dual stimuli-responsive lanthanide-based phosphors were prepared for constructing a multilevel full color anti-counterfeiting system, augmenting the security level for information protection.
UV-cured eutectic gel polymer electrolytes for safe and robust Li-ion batteries
Authors: Logan Matthew W. , Langevin Spencer , Tan Bing , Freeman Adam W. , Hoffman Christopher , Trigg Douglas B. , Gerasopoulos Konstantinos
Published: April 2020

We report UV-cured eutectic gel polymer electrolytes that improve cell performance, non-flammability, and water tolerance compared to the liquid solvent.
Boron-based nanosheets for combined cancer photothermal and photodynamic therapy
Authors: Kang Yong , Ji Xiaoyuan , Li Zhengjun , Su Zhiguo , Zhang Songping
Published: April 2020

Tumor phototherapy is of great significance for the expansion and advancement of cancer treatment methods.
A fiber-shaped neural probe with alterable elastic moduli for direct implantation and stable electronic–brain interfaces
Authors: Tang Chengqiang , Xie Songlin , Wang Mengying , Feng Jianyou , Han Zhengqi , Wu Xiaoying , Wang Liyuan , Chen Chuanrui , Wang Jiajia , Jiang Liping , Chen Peining , Sun Xuemei , Peng Huisheng
Published: April 2020

A fiber-shaped neural probe with alterable elastic moduli allows direct implantation and enables adaptive electronic–tissue interfaces post implantation.
Photoinduced cationic polycondensation in solid state towards ultralow band gap conjugated polymers
Authors: Liu Xunshan , Sharapov Valerii , Zhang Zhen , Wiser Forwood , Awais Mohammad Ahmad , Yu Luping
Published: April 2020

A photoinduced cationic polycondensation towards the synthesis of homopolymer PTT.
Mechanical stimulation induced osteogenic differentiation of BMSCs through TWIST/E2A/p21 axis
Authors: Guo Qingyuan , Liu Ying , Sun Renhao , Yang Fang , Qiao Pengyan , Zhang Rong , Song Ling , E Lingling , Liu Hongchen
Published: April 2020

The relationship between mechanical force and alveolar bone remodeling is an important issue in orthodontics because tooth movement is dependent on the response of bone tissue to the mechanical force induced by the appliances used. Mechanical cyclical stretch plays an essential role in the cell osteogenic differentiation involved in bone remodeling. However, the underlying mechanisms are unclear, particularly the molecular pathways regulated by mechanical stimulation. In the present study, we reported a dynamic change of p21 level in response to mechanical cyclical stretch, and shRNA-p21 in bone marrow mesenchymal stem cells (BMSCs) induced osteogenic differentiation. The mechanism was mediated through TWIST/E2A/p21 axis. These results supported the mechanical stimulation-induced osteogenic differentiation is negatively regulated by p21.
Output feedback controller for trajectory tracking of robot manipulators without velocity measurements nor observers
Authors: Rascón Raúl , Moreno‐Valenzuela Javier
Published: April 2020

The main contribution of this study is the design of a trajectory tracking controller using output feedback applied to robot manipulators. The given controller does not need velocity measurements for its implementation and to achieve the tracking control objective. The structure of the proposed scheme consists of a proportional gain plus a dynamic gain resulting from a first‐order system. The dynamic gain is not motivated by any observer nor estimator to approach the joint velocity. The dynamic linear controller has three tunable gain parameters for the one degrees‐of‐freedom (DOF) systems and two gain matrices for the n DOF lagrangian systems. These gains can be tuned following the conditions given in the stability analysis. An adaptive estimator of the viscous friction coefficient is added to robustify the closed‐loop design; the analysis for the estimator is presented for one DOF systems and n DOF manipulators. The closed‐loop stability analyses are developed by using Lyapunov's theory. The performance of the proposed control structure is illustrated and compared with other controllers such as the PID controller and the first‐order sliding mode algorithm via numerical simulations. Moreover, real‐time experiments are carried out in a two DOF SCARA robot manipulator.
Investigation of the key secondary parameter effecting on transverse force in the single‐sided linear induction motor
Authors: Zhou Tong , Lv Gang , Zeng Dihui
Published: April 2020

This study mainly investigates the key secondary parameter effecting on transverse force and the changing trend of its components, which include the repulsive and restoring components. Firstly, considering the transverse displacements, skin effect and end effects, the full 3D finite element models of the single‐sided linear induction motor (SLIM) are built. Secondly, when the width of the secondary varies, the transverse force and its two components are presented and analysed. At the same time, the air‐gap flux densities and the eddy currents along the transverse directions are calculated. Then when the topological transform of aluminium plate (e.g. Al‐cap type) and back‐iron plate (e.g. laminated type) are applied, the transverse force and its components are given. Finally, the transverse force, thrust and efficiencies are compared in the SLIMs with different secondaries as well as some experiments are given. It is shown that the width of the secondary is the main factor influencing the transverse force.
Outlier detection in neutrosophic sets by using rough entropy based weighted density method
Authors: Sangeetha Tamilarasu , Amalanathan Geetha Mary
Published: April 2020

Neutrosophy is the study of neutralities, which is an extension of discussing the truth of opinions. Neutrosophic logic can be applied to any field, to provide the solution for indeterminacy problem. Many of the real‐world data have a problem of inconsistency, indeterminacy and incompleteness. Fuzzy sets provide a solution for uncertainties, and intuitionistic fuzzy sets handle incomplete information, but both concepts failed to handle indeterminate information. To handle this complicated situation, researchers require a powerful mathematical tool, naming, neutrosophic sets, which is a generalised concept of fuzzy and intuitionistic fuzzy sets. Neutrosophic sets provide a solution for both incomplete and indeterminate information. It has mainly three degrees of membership such as truth, indeterminacy and falsity. Boolean values are obtained from the three degrees of membership by cut relation method. Data items which contrast from other objects by their qualities are outliers. The weighted density outlier detection method based on rough entropy calculates weights of each object and attribute. From the obtained weighted values, the threshold value is fixed to determine outliers. Experimental analysis of the proposed method has been carried out with neutrosophic movie dataset to detect outliers and also compared with existing methods to prove its performance.
Properties of OB star−black hole systems derived from detailed binary evolution models
Authors: Langer N. , Schürmann C. , Stoll K. , Marchant P. , Lennon D. J. , Mahy L. , de Mink S. E. , Quast M. , Riedel W. , Sana H. , Schneider P. , Schootemeijer A. , Wang C. , Almeida L. A. , Bestenlehner J. M. , Bodensteiner J. , Castro N. , Clark S. , Crowther P. A. , Dufton P. , Evans C. J. , Fossati L. , Gräfener G. , Grassitelli L. , Grin N. , Hastings B. , Herrero A. , de Koter A. , Menon A. , Patrick L. , Puls J. , Renzo M. , Sander A. A. C. , Schneider F. R. N. , Sen K. , Shenar T. , Simón-Días S. , Tauris T. M. , Tramper F. , Vink J. S. , Xu X.-T.
Published: April 2020

Context. The recent gravitational wave measurements have demonstrated the existence of stellar mass black hole binaries. It is essential for our understanding of massive star evolution to identify the contribution of binary evolution to the formation of double black holes.

Aims. A promising way to progress is investigating the progenitors of double black hole systems and comparing predictions with local massive star samples, such as the population in 30 Doradus in the Large Magellanic Cloud (LMC).

Methods. With this purpose in mind, we analysed a large grid of detailed binary evolution models at LMC metallicity with initial primary masses between 10 and 40 M⊙, and identified the model systems that potentially evolve into a binary consisting of a black hole and a massive main-sequence star. We then derived the observable properties of such systems, as well as peculiarities of the OB star component.

Results. We find that ∼3% of the LMC late-O and early-B stars in binaries are expected to possess a black hole companion when stars with a final helium core mass above 6.6 M⊙ are assumed to form black holes. While the vast majority of them may be X-ray quiet, our models suggest that these black holes may be identified in spectroscopic binaries, either by large amplitude radial velocity variations (≳50 km s−1) and simultaneous nitrogen surface enrichment, or through a moderate radial velocity (≳10 km s−1) and simultaneous rapid rotation of the OB star. The predicted mass ratios are such that main-sequence companions can be excluded in most cases. A comparison to the observed OB+WR binaries in the LMC, Be and X-ray binaries, and known massive black hole binaries supports our conclusion.

Conclusions. We expect spectroscopic observations to be able to test key assumptions in our models, with important implications for massive star evolution in general and for the formation of double black hole mergers in particular.
Improved method for determination of waxes in olive oils: reduction of silica and use of a less hazardous solvent
Authors: Milani Andrea , Lucci Paolo , Sedran Martina , Moret Erica , Moret Sabrina , Conte Lanfranco
Published: April 2020

The evaluation of the content of waxes is request both by IOC Trade Standard and by Regulation (EEC) 2568/91 and its further amendments. The official method uses 15 g of silicic acid and elutes several fractions by using huge volumes of dangerous solvent (n-hexane). The developed method uses 1 g of silicic acid with a different particle size and less than 20 mL of solvent mixture, substituting n-hexane with less toxic isooctane. Briefly, after spiking with a suitable internal standard, oil sample is fractionated by SPE (Solid Phase Extraction) cartridge with 1 g of silica, waxes are eluted with 14 mL of isooctane/ethyl ether 99/1 (6 mL discarded and 8 mL collected), then, after elution sample is reconstitute in 200 μL of n-heptane and analysed by capillary GC. Data of “In home” validation, (repeatability, accuracy and recovery) and relative chromatograms are reported in this paper.
Erkrankungen des Tränenapparats, Teil 2: Grundlagen der Therapie
Authors: Heichel Jens , Struck Hans-Gert , Viestenz Arne , Glien Alexander , Plontke Stefan
Published: April 2020

The tearing eye (epiphora) is deemed to be the leading symptome of efferent tear duct stenosis. Nevertheless, epiphora might be caused by ocular surface pathologies or even intraocular diseases. A distinguished anamnesis and sufficient clinical examination is most meaningful for the differential diagnostic distinction. Therapy is based on pathologic changes. In case of ocular surface disease, a suitable tear substitution and antiinflammatory approach is mandatory. Multifarious triggers have to be considered as well. Addressing tear film distribution, suitable oculoplastic surgery is required. Efferent tear duct stenosis necessitates surgical treatment as the level of suffering is often very high and acute exacerbations may develop. Besides recanalization, anastomosing techniques represent the available therapeutic principles. Possible surgical approaches offer a great variety and many influencing factors navigate therapy decisions. This part of the review comments on the most important therapeutic approaches for lacrimal apparatus diseases.
Barrett-Screening: rationale, aktuelle Konzepte und Perspektiven
Authors: Weismüller Josef , Thieme René , Hoffmeister Albrecht , Weismüller Tobias , Gockel Ines
Published: April 2020

Der Barrett-Ösophagus (BE) stellt den wichtigsten Risikofaktor für das ösophageale Adenokarzinom dar. Derzeit ist kein hinreichend effizientes Screening-Programm verfügbar, um in der Gesamtpopulation Patienten mit einem hohen Risiko für ein ösophageales Adenokarzinom auf dem Boden eines Barrett-Ösophagus zu identifizieren. Das aktuelle endoskopische Screening zielt auf symptomatische Refluxpatienten, aus denen sich aber nur ein Teil der Risikopatienten rekrutiert. Derzeit werden verschiedene neue Verfahren untersucht, die die Effektivität des Screenings deutlich erhöhen könnten.

Selektive Literaturrecherche in MEDLINE/PubMed unter Berücksichtigung deutscher und internationaler Leitlinien.

Alternative Screening-Verfahren könnten 2-stufig angelegt sein: Zunächst die Identifikation von Personen „at risk“ über eine Erfassung geeigneter biologischer Marker, dann deren gezielte endoskopisch-bioptische Abklärung, Risikostratifikation, Überwachung (Surveillance) und ggf. Therapie. Neue diagnostische Methoden wie der Cytosponge® in Kombination mit einer Auswertung von Markern für Barrett-Schleimhaut könnten einen wesentlichen Fortschritt darstellen.

Barrett-Karzinome zeigen nach wie vor eine zunehmende Inzidenz und eine (trotz therapeutischer Fortschritte) ungünstige Prognose, wobei aber Patienten mit Barrett-Frühkarzinomen eine gute Prognose hinsichtlich Langzeitüberleben aufweisen. Eine verbesserte Früherkennung ist dringend wünschenswert, da bisher die meisten Patienten erst im fortgeschrittenen Stadium endoskopisch diagnostiziert werden, was eine kurative Therapie erschwert. Nur eine effiziente frühzeitige Identifizierung von Risikopatienten mit Barrett-Ösophagus durch ein praktikables Screening-Programm auf Populationsebene wird zur Verbesserung der Prognose beitragen können.
„Die einzige Art, gegen die Pest zu kämpfen, ist die
Ehrlichkeit“ (A. Camus)
Authors: Singer Dominique
Published: April 2020

Liebe Leserinnen und Leser,

in dem 1947 erschienenen Roman „Die Pest“ des franko-algerischen
Literaturnobelpreisträgers Albert Camus spricht der Arzt Bernard Rieux,
indem er jede Art von „Heldentum“ im Kampf gegen die Seuche von sich
weist, die Worte: „… la seule façon de lutter contre la
peste, c‘est l’honnêteté“. Eine
Aussage, die sich angesichts der aktuellen Coronavirus-Pandemie in geradezu
bedrückender Weise bestätigt. Haben wir es doch auch heute mit einer
Reihe von „Unbedachtheiten“ zu tun, die das Ausmaß der Krise
begünstigt haben.
Gastrointestinal Ultrasound (GIUS) in Intestinal Emergencies – An EFSUMB Position Paper
Authors: Hollerweger Alois , Maconi Giovanni , Ripolles Tomas , Nylund Kim , Higginson Antony , Serra Carla , Dietrich Christoph F. , Dirks Klaus , Gilja Odd Helge
Published: April 2020

An interdisciplinary group of European experts summarizes the value of gastrointestinal ultrasound (GIUS) in the management of three time-critical causes of acute abdomen: bowel obstruction, gastrointestinal perforation and acute ischemic bowel disease. Based on an extensive literature review, statements for a targeted diagnostic strategy in these intestinal emergencies are presented. GIUS is best established in case of small bowel obstruction. Metanalyses and prospective studies showed a sensitivity and specificity comparable to that of computed tomography (CT) and superior to plain X-ray. GIUS may save time and radiation exposure and has the advantage of displaying bowel function directly. Gastrointestinal perforation is more challenging for less experienced investigators. Although GIUS in experienced hands has a relatively high sensitivity to establish a correct diagnosis, CT is the most sensitive method in this situation. The spectrum of intestinal ischemia ranges from self-limited ischemic colitis to fatal intestinal infarction. In acute arterial mesenteric ischemia, GIUS may provide information, but prompt CT angiography is the gold standard. On the other end of the spectrum, ischemic colitis shows typical ultrasound features that allow correct diagnosis. GIUS here has a diagnostic performance similar to CT and helps to differentiate mild from severe ischemic colitis.
Reductive Amination of Aryl Boronic Acids: Parallelism of the Catalytic Reactivity of Transition Metals and Main Group Elements in the C(sp2)–N Bond-Forming Reactions
Authors: Magdesieva Tatiana V. , Levitskiy Oleg A.
Published: April 2020

The results of the DFT studies on the mechanism of the PIII/PV=O catalyzed reductive amination of nitrosoarenes using ArB(OH)2 yielding diaryl amines are reported. This allowed a comparison of the reaction paths and key intermediates of the Cu(I)- and P(III)-mediated reductive aminations of aryl boronic acids using alkylnitrites, nitroso- or nitroarenes, and revealed important similarities in the catalytic reactivity of transition-metal and main-group elements in C(sp2)–N bond-forming reactions. It is shown that both transformations occur via ambiphilic nitrenoid-type key intermediates, the reactivity of which towards the aryl boronic acid is attributed to the presence of both a Lewis acid center (Cu or P) and a Lewis base center (the N or O atoms of the ‘N=O’ component).
Influence of Antagonist Material on Fatigue and Fracture Resistance of Zirconia Crowns
Authors: Nawafleh Noor , Bibars Abdel Raheem , Al Twal Elina , Öchsner Andreas
Published: April 2020

Objective This study investigates the influence of the most commonly used indenter materials on fatigue survival and fracture resistance of zirconia crowns.

Materials and Methods A total of 40 zirconia crowns were prepared using computer-aided design (CAD)/computer-aided manufacturing (CAM) technology: 30 crowns were divided into three experimental groups of 10 specimens and the last 10 specimens acted as the control group. The experimental groups were subjected to chewing simulation with simultaneous thermocycling. Three indenter materials (steatite ceramic, stainless steel, and tungsten carbide) with identical diameter were used to load the specimens. All crowns were then subjected to single load to fracture test in universal testing machine. Load was applied vertically with a crosshead speed of 1 mm/min until failure, and fracture load was recorded.

Statistical Analysis Normal distribution of data was confirmed using the Shapiro–Wilk test. Descriptive statistics including means and standard deviations were determined for all groups. Differences between groups were tested using Dunnett’s test and paired sample t-test.

Results Chewing simulation for 1.2 million cycles resulted in 100% survival. The highest mean fracture load was recorded for the control group and the lowest one was for the group fatigued with stainless steel indenter. Chewing simulation statistically significantly (p < 0.05) reduced the mean fracture load of the crowns fatigued with stainless steel and steatite ceramic indenter. However, the mean fracture load for the crowns fatigued with tungsten carbide was not significantly different from that of the control group.

Conclusion Steatite ceramic and stainless steel indenters produced close results and significantly reduced fracture load of zirconia crowns. However, tungsten carbide indenter caused nonsignificant reduction in the fracture load of zirconia crowns.
Unfolding Various Concepts of Junctional Epithelium
Authors: Puvvalla Bhavana , A. Suchetha , Mundinamanae Darshan B. , M. Apoorva S. , Bhat Divya
Published: April 2020

The Gingival epithelium comprises of three different areas based on their anatomical and functional points of view 1) the oral or outer epithelium (OGE), 2) Sulcular epithelium (SE) and 3) Junctional epithelium (JE). The junctional epithelium may be regarded as the most interesting structure of the gingiva. The formation of junctional epithelium in the implant/mucosal interface can be considered as the first barrier of defense against oral micro flora. Any kind of disruption of this barrier will lead to initiation and progression of progression of periodontal disease. Hence, in this review we made an attempt to wrap various concepts of junctional epithelium formation, its role in disease progression and its relation to the implant surface.