bluuebunny/crossref_metadata_2025 huggingface dataset:
Fístula rectovaginal en el cáncer de recto localmente avanzado
Authors: Crespo Alvarez Marco Antonio , Labalde Martínez María , Peralta Fernandez-Revuelta Paola , Guibert Patiño Andre Luis , Ferrero Herrero Eduardo
Published: December 2024

Introducción: El cáncer de recto localmente avanzado es una causa poco frecuente de fistula rectovaginal. Una vez establecida la fistula, la cirugía es el único tratamiento curativo.
Objetivo: Presentar el caso de una mujer de 48 años con cáncer de recto localmente avanzado asociado a una fistula rectovaginal.
Material y Métodos: Mujer de 48 años que presenta alteraciones de ritmo intestinal, rectorragia y expulsión de moco marronáceo a través de la vagina, lesión pétrea a 2 cm del margen anal y una fistula rectovaginal. Se confirma el diagnóstico mediante colonoscopia, Tomografía Computarizada y Resonancia Magnética, siendo diagnosticada de tumor cT4bN0M0 de la AJCC 8th edición.
El caso es presentado en el comité multidiscipinar de tumores en el que se decide colostomía, posterior neoadyuvancia con quimioterapia y radioterapia, revaluación y cirugía mediante amputación abdominoperineal y resección de la pared vaginal infiltrada.
Resultados: Se realiza una colostomía lateral laparoscópica, con posterior quimioterapia neoadyuvante y radioterapia.
A las 8 semanas de finalizar la quimioterapia se realiza una amputación abdominoperineal laparoscópica con resección de pared posterior de vagina en bloque. Sin complicaciones postoperatorias y la paciente es dada de alta al 8º día postoperatorio.
El informe patológico es ypT0N0 (8ºed AJCC-UICC TNM).
Conclusión: El plan terapéutico debe estar guiado por un equipo multidisciplinar. En el tratamiento del cáncer de recto localmente avanzado asociado a fístula rectovaginal es recomendable realizar una colostomía previa a la neoadyuvancia y la cirugía curativa incluye resecciones radicales como la amputación abdominoperineal con resección en bloque de la pared vaginal.
Estudio crítico a la Ley 2/2023 de 20 de febrero, análisis de la figura del Whistleblower y la lucha contra la corrupción
Authors: Lledó Benito Ignacio
Published: December 2024

En esta obra el autor lleva a cabo un intenso y extenso estudio de la Ley 2/2023 de 20 de febrero reguladora sobre la protección de las personas informantes y lucha contra la corrupción. La Ley 2/2023 es fruto de la implementación de la Directiva UE 2019/1937 o Directiva Whistleblowing, a su vez originaria de la figura anglosajona del whistleblower o informante de delitos en multitud de campos desde el económico al espionaje. El autor hace un estudio desde el origen del whistleblower en los EEUU, así como los casos más importantes de la Historia. En el estudio de la Ley 2/2023 analiza los puntos que abarcan al Derecho penal: analizando la prohibición de cualquier represalia, el anonimato de las denuncias, el canal de denuncias interno, externo y la revelación pública, así como una posible exención de pena o atenuación ante la denuncia de un delito de corrupción y sus consecuencias penales tanto en el sector público como en el privado. Se examina la figura del whistleblower como un ejercicio leal de colaboración ciudadana que tiene como objetivo la comunicación de infracciones para el interés público y la ética en la figura del informante que actúa de buena fe, denunciando cualquier vulneración del ordenamiento jurídico y que permite como destaca la mejor doctrina, respetar las garantías básicas que deben ser reconocidas a toda persona que pueda ampararse bajo el estatuto de protección al whistleblower/informante, sobre todo, en el ámbito penal.
Pengaruh Motion Graphic di SMK 54 Jakarta terhadap Peningkatan Pemahaman tentang Perpustakaan
Authors: Prakoso Ario Adi , Prayogo Muhamad Yanuar
Published: December 2024

Penetapan Pandemi Covid-19 oleh pemerintah membuat banyak kegiatan yang gagal dilaksanakan. Salah satu contohnya yaitu kegiatan Masa Orientasi Siswa (MOS) di SMKN 54 Jakarta pada tahun ajaran 2021-2022 tidak dapat terlaksana, sehingga mengakibatkan siswa tidak mendapatkan pendidikan pemakai perpustakaan. Dampaknya banyak siswa yang tidak tahu tentang koleksi, layanan, dan fasilitas yang ada di perpustakaan. Pada penelitian ini bertujuan untuk menarik minat siswa dan siswi untuk lebih mengenal perpustakaan di SMKN 54 Jakarta dengan cara  menggunakan motion graphic. Selain itu juga sekaligus untuk melaksanakan pendidikan pemakai yang sempat tidak terealisasikan selama masa pandemi Covid-19.  Penelitian ini menggunakan metode penelitian Pre Eksperimen desain dengan desain penelitian One-Group Pretest-Posttest Design. Hasil uji normalitas pre-test mendapatkan nilai sebesar 0,117 > 0,05, dan pada post-test mendapatkan nilai sebesar 1,131 > 0,05 hal ini menunjukkan bahwa seluruh data terdistribusi secara normal. Hasil yang diperoleh dari paired sample t-test diperoleh nilai signifikansi sebesar 0,000 pada taraf signifikan 5%. Hasil 0,000 < 0,05 maka dapat disimpulkan bahwa penelitian ini menunjukkan adanya signifikansi positif yang berarti bahwa hipotesis dalam penelitian ini diterima yakni adanya pengaruh motion graphic di SMKN 54 Jakarta terhadap peningkatan pemahaman tentang perpustakaan.
The „limited recognition” problem and the international presence of the Republic of Kosovo
Authors: Szeląg Paulina
Published: December 2024

This paper aims to examine the connection between foreign policy of the states with limited recognition and their security. Author analyzes the position of Kosovo in international relations. Explaines differences between de facto states, quasi-states, unrecognized states, pseudo states and states with limited recognition, arguing that Kosovo should be consider as the latter. Author also points out consequences of international recognition (including the case of Kosovo), shows the main goals of foreign policy of this state and relations between Kosovo and international governmental organizations, which conduct ‘engagement without recognition policy’ and selected countries, which recognized Kosovo as a sovereign state. The paper is based on examination of primary and secondary sources, critical analysis of sources and data analysis. Author argues that limited recognition of Kosovo has a direct influence on foreign policy of this state. This foreign policy is strictly connected with security issues. However, limited recognition reduced foreign policy of Kosovo and made that this country cannot be a party of military pacts, which is crucial in maintaining peace and security in this country.
Lesson for the future climate migration. A study of relocation and development of new settlements in urban peripheries based on spatial dispersion of forced migrants in Serbia between 1991 and 2021
Authors: Chodorowski Michał , Božilović Jelena , Adamski Jakub , Messyasz Karolina , Rekść Magdalena , Milošević Vuk , Ilić Ana
Published: December 2024

Climate migrations are going to affect the spatial structure in many regions of the world. We are now able to research long-term displacement and its spatial effects. Using the example of Serbia and the 30-year history of migration after the conflicts connected with the collapse of the former Yugoslavia, the article analyses the accompanying processes. The aim of this article is to study the spatial effects of long-term (forced) migration. The research is based on sociological and spatial planning methods, i.e. statistical data, geospatial information and institutional document analysis. The analyses show social and spatial trends in migration and settlement formation in Serbia between 1991 and 2021.
Armia wielkiego wezyra Kara Mustafy wobec ludności atakowanych obszarów Węgier i Austrii podczas wyprawy wiedeńskiej 1683 r. w świetle wybranych źródeł osmańskich
Authors: Wybranowski Dariusz
Published: December 2024

Celem artykułu jest analiza metod postępowania armii osmańskiej pod dowództwem wielkiego wezyra Kara Mustafy i wspierających go Tatarów wobec ludności z obszarów Węgier i Dolnej Austrii podczas tureckiej wyprawy na Wiedeń w 1683 roku. Podstawowymi źródłami są relacje kronikarzy (Silahdar Mehmed aga z Fyndykły, Dżebedżi Hasan Esiri) i historyków (Husein Hezarfenn, defterdar Sari Mehmed Pasza) z doby osmańskiej. Ważnymi przekazami są listy wielkiego wezyra do mieszkańców węgierskiego miasta Sopron i Wiednia. Z relacji tych wynika, że siły osmańskie dążyły do opanowania niektórych miast i samego Wiednia bez walki, licząc na ich kapitulację. Udało się także pozyskać niektórych możnowładców węgierskich wrogo nastawionych do Habsburgów (Imre Thököly, rody Batthyanych, Draskovicsów). Wobec miejscowej ludności stosowano jednak przede wszystkim terror, który oznaczał eksterminację jeńców – wojskowych (tzw. „języków”) i cywili oraz branie kobiet i dzieci w niewolę (jasyr). Kronikarze relacjonują m.in. przypadki nagradzania żołnierzy osmańskich i Tatarów w zamian za dostarczanych jeńców, których potem mordowano. Liczne są informacje o niszczeniu zajmowanych obszarów, masowych rabunkach i gwałtów na kobietach oraz chłopcach. Atakowane obszary zostały niemal całkowicie zniszczone a ludność zdziesiątkowana. Jak wynika z obliczeń, podczas tych wydarzeń zginęło lub zostało wziętych do niewoli od 80 do ponad 100 tysięcy mieszkańców.
Political activities of Sophronius Vrachanski
Authors: Rusin Bartłomiej
Published: December 2024

The beginning of the 19th century was a difficult period for the Bulgarian population, caused by a deep crisis in the Ottoman Empire and another Russo–Turkish war of 1806–1812. During the conflict, the former bishop of Vratsa, Sophronius, together with a circle of activists, undertook political action to support the Russian military effort and help the civilian population fleeing the horrors of the war. This action ultimately ended in failure, as it was not possible to obtain autonomy for the Bulgarians, but the political program they developed was an important stage in the formation of the native national liberation movement. Thanks to his achievements, Sophroniy is known in Bulgarian historiography not only as a priest and one of the codifiers of the modern Bulgarian language, but also as a political activist.
Un parere in merito alla secolarizzazione Wisława Szymborska su Dio, Secolarizzazione e Anima
Authors: Sierotowicz Tadeusz
Published: December 2024

Il saggio è un tentativo di rileggere alcune poesie di Wisława Szymborska cercando di delineare il suo parere in merito alla secolarizzazione. Contestualmente viene affrontato il tema dell’anima e la questione di Dio, che assieme costituiscono i tre capitoli del racconto della secolarizzazione.
Wkład abp. Ignacego Tokarczuka w budowanie społeczeństwa obywatelskiego na zasobach religijnych w państwie totalitarnym
Authors: Jedynak Witold
Published: December 2024

Celem opracowania jest przedstawienie wkładu abp. Ignacego Tokarczuka w przygotowanie — w oparciu o zasoby religijne — podłoża społecznego w państwie komunistycznym pod budowę społeczeństwa obywatelskiego. Na podstawie analizy źródeł zastanych ustalono, że Tokarczuk, wdrażając zasady katolickiej nauki społecznej, a także wykorzystując prawidłowości funkcjonowania religijnych społeczności lokalnych i mechanizmy umożliwiające ich rozwój, przyczynił się nie tylko do progresu życia religijnego, lecz także zintegrował, upodmiotowił i zaktywizował mieszkańców diecezji przemyskiej. Wyzwalając kapitał społeczny i umiejętnie nim zarządzając, kształtował u obywateli dyspozycje do współdziałania, samoorganizacji, samorządności i podejmowania oddolnych inicjatyw na rzecz dobra wspólnego, a także rozbudował sieci społecznego zaangażowania niezbędne do funkcjonowania społeczeństwa obywatelskiego.
Ideologizacja ducha Soboru Watykańskiego II w świetle nauczania Josepha Ratzingera/ Benedykta XVI (1927–2022)
Authors: Ferdek Bogdan
Published: December 2024

Ratzinger odczytuje II Sobór Watykański w świetle najbardziej katolickiej litery alfabetu, czyli litery „i”. Uważa bowiem, że katolik nie może przeciwstawiać Soboru Watykańskiego II Soborowi Trydenckiemu lub Watykańskiemu I i odwrotnie. Ratzinger nie uznaje zatem alternatywy „albo–albo” — albo Sobór Trydencki i Watykański I, albo Watykański II. To zwolennicy ideologii stają wobec alternatywy „albo–albo” i przeciwstawiają sobie Sobory: Watykański II Watykańskiemu I oraz Trydenckiemu i odwrotnie. Ratzinger, stosując hermeneutykę ciągłości, nie ulega antyduchowi Soboru. Antyduch Soboru zrywa z tym, co było przed Soborem, w imię zasady, że wszystko, co nowe lub rzekomo nowe, jest o wiele lepsze od tego, co było lub co jest. W taki sposób interpretuje Sobór „skrzydło postępowe”, które można określić mianem „progresizmu”. Oprócz „skrzydła postępowego” istnieje w Kościele również „tradycjonalizm”, który można określić mianem „integryzmu”. Dla tradycjonalistów istnieje tylko Kościół przed Soborem. Tak jak dla progresistów nowe jest lepsze od starego, tak dla integrystów stare jest lepsze od nowego. Chociaż progresistów jest więcej niż integrystów, to jednak ci ostatni mają ściśle określone struktury. Ten antyduch Soboru zdaje się stawać ideologią. Ideologia jest systemem, którego celem jest realizacja jakiejś utopii. W kontekście antyducha Soboru Ratzinger przypomina „ojca rodziny, który ze swego skarbca wydobywa rzeczy nowe i stare” (Mt 13,52). Dla niego Sobór pochodzi od Ducha Świętego, który posługiwał się ludźmi. Od Ducha Świętego pochodzi prawdziwy duch Soboru, któremu litery dali ludzie Soboru.
Editorial: Labour Market and Unemployment
Authors: Janicki Tadeusz
Published: December 2024

Labour is a key factor of production, enabling the production of goods and services. Throughout history, the labour market situation has influenced economic growth and development, and hence investment, productivity, income, consumption and society's standard of living. The articles contained in the next volume of the journal Studia Historiae Oeconomicae analyze the above problem using selected examples dating back to the 18th century. The presented SHO volume consists of eight articles that provide authentic knowledge on such labour market shaping factors as wages, ideology and politics, as well as on the activities of labor unions and charitable organizations under different political and socio-economic systems. The study of labour and the labour market has a heavy burden for both cognitive and practical reasons, since knowledge of the causes, mechanisms and dynamics of change in this sphere can help optimize economic policies regarding the labour market as well as become a source of inspiration for readers and perhaps further research in this area.
Unfulfilled Dreams? The Financial Situation of Workers in Paris and the Department of Loir-et-Cher between 1789 and 1795
Authors: Derejski Krzysztof
Published: December 2024

The convening of the Estates General in France in 1789 raised high hopes in French society for change. The economic demands written down in the ledgers of complaints, such as the abolition of the guild system, the unification of taxes and their more equitable distribution, the abolition of customs duties and fees within the kingdom, can be categorized as inclusive economic institutions. Their introduction in France during the Revolution was expected to translate into an improvement in the financial conditions of the population. The purpose of this article is to present the changing financial situation of workers in Paris and the department of Loir-et-Cher between 1789 and 1795 in the context of the aforementioned institutions. Data from a survey of prices and wages conducted at the behest of the Committee of Public Safety, Paris police reports of 1795 and depreciation tables were used to show the change in the financial position of working families during the French Revolution. Demands from the ledgers of complaints against the Estates General of 1789 were used to determine the title workers' "dreams." Assessing the change in the financial situation of workers required calculations that took into account, among other things, the size of the average working family's demand for foodstuffs or the change in France regarding the number of working days per year after the elimination of the old holidays and the introduction of the republican calendar. During the period under review, the financial situation of workers in the Loir-et-Cher department worsened due to high inflation – turning at times into hyperinflation – despite the implementation of most of the demands of the ledgers of complaints by the revolutionary authorities. In the case of Paris, the assessment is not so clear-cut. Thanks to the rationing of bread and meat in the capital, and their sale at a discounted price by the authorities, the living conditions of working families in 1795 were better or comparable to those at the beginning of the revolution. The article sheds new light on the changing financial situation of workers in Paris and the department of Loir-et-Cher in the context of the implementation of workers' demands recorded during the revolution in the ledgers of complaints to the Estates General of 1789, thus filling a gap in historiography.
On the Road to the Split of the American Labor Movement: Criticism of the American Federation of Labor In Committee for Industrial Organizations Pamphlets (1935–1936)
Authors: Kowalski Kamil
Published: December 2024

The US labor movement gained momentum after the passage of the NIRA (1933) and especially the Wagner Act (1935). The new law guaranteed employees the right to organise and bargain collectively through representatives of their own choosing. The dynamic growth in union membership was accompanied by a heated debate over whether unions should be organised to cover all workers in an industry or on an occupational or craft basis. This piece covers Committee of Industrial Organizations (CIO) pamphlets published between 1935 and 1936, a critical period in the rivalry between the American Federation of Labor (AFL) and the CIO. Most took the form of journalistic commentary on current events in the union environment. The pamphlet, as a form of communication, by definition, presents a one-sided description of reality. Nevertheless, the CIO pamphlets are a valuable source of knowledge about the division in the American labor movement in the 1930s. In this piece, I examine the axes of contention and arguments. They cover various issues, such as an assessment of the US trade union movement’s achievements, jurisdictional claims, industrial charters, and dues. I trace the evolution of radicalism in the views of the CIO leadership, from reforming the Committee in the spirit of “unionising unorganised mass production under the banner of the AFL” to massive criticism of the Federation that ultimately made further coexistence impossible. The latter resulted in the AFL suspending the CIO in September 1936.
Hidden Unemployment in Polish Industry (1945–1956)
Authors: Chumiński Jędrzej
Published: December 2024

One of the main factors determining the weakness of the socialist economy was the phenomenon of hidden unemployment, which means excessive employment in industrial plants in relation to needs. This phenomenon should be considered in two aspects: economic and social. The aim of this article is to determine the economic and social consequences of the phenomenon of hidden unemployment in the Polish economy in the first years after the WWII. The article is based on the literature on the subject, as well as source research conducted at the Archives of New Records and the Archives of the Institute of National Remembrance in Warsaw. To analyze the socio-demographic characteristics of the staff of four industrial plants, the personal files of employees collected in the plant archives were used. The research conducted indicates that one of the main sources of weakness of the socialist economy was the situation on the labor market, and especially the phenomenon of over-employment. In the economic sphere, it meant that the dominance of an excessive number of low-skilled workers in the composition of the industrial workforce resulted in poor labor productivity, abysmal production quality, non-compliance with standards in technological processes, destruction of work ethics, poor discipline, increased personnel turnover, etc. It is a measure of the irrationality of the system that the employment of a significant proportion of these workers was not the result of either economic or social necessity, but a consequence of the erroneous economic development model adopted, based on the use of low-skilled and poorly paid labor. In social terms, however, the employment of these people meant that the communist regime could count on relatively considerable public support among them. Authoritarian, non-democratic parties (such as the PPR and PZPR), appealing to populist slogans and fomenting conflicts with other social groups corresponded in terms of their programs and modus operandi to people with high levels of authoritarian attitudes.
Book Review: The Importance of Constitutional Rules and Property Rights. The German Economy in 1990–2015
Authors: Moszyński Michał
Published: December 2024

The book titled The Importance of Constitutional Rules and Property Rights. The German Economy in 1990–2015 prepared by Damian Bębnowski, a researcher at the University of Lodz was published in 2022 by Peter Lang. This comprehensive 440-page monograph is devoted to an important event in recent German history, namely, the reunification and the period of building a social market economy order in the former GDR during the period indicated in the title.
La percezione disturbata e le sue conseguenze in «Almost blue» di Carlo Lucarelli
Authors: Kornacka Barbara
Published: December 2024

Distorted Perception and its Consequences in «Almost Blue», a Novel by Carlo Lucarelli is an article which deals with an analysis and description of the three main characters from the perspective of their sensory perception of reality. In each analysed case the main characters' experiences are distorted (damaged, misinterpreted) due to blindness, mental disease or Premenstrual Syndrome. The distorted sensory perception affects their contact with reality and their understanding of certain phenomena. Their individual human corporality changes the sense of reality.
Misoginism. Femme fatale. Androgyne - despre creatiile feminine în proza lui Mateiu Caragiale
Authors: Kornas-Warwas Joanna
Published: December 2024

The article tells about the female characters in Mateiu Caragiale's literary work and tries to depict the characteristics of modern prose in 1930s that reflect the tendencies concentrated on the idea of „battle of the sexes". The emancipation and the changing role of women in the society led to the phenomenon of misogyny, while the image of femme fatale became a popular literary theme. On the other hand there existed the archetype of Androgyne that become a perfect incarnation of both sexes. All these aspects mentioned above found a reflection in Mateiu Caragiale's novel „Craii de Curtea Veche" proving the universal character of his work.
Une illustration littéraire du mythe de l'Éternel Retour : « Le Jardin des supplices » d'Octave Mirbeau (1899)
Authors: Lair Samuel
Published: December 2024

In Mirbeau's novel Le Jardin des supplices (1899), the circular representation, completed and relayed by design of the plant, should be read violently. The reader conceives some philosophical influences or convergences. The Narcissus myth is subjected here to a literary transmutation. The novel tells a personal obsession; it becomes a reconciliation between earlier fictions [L'Abbé Jules (1888), Dans le ciel (1892-1893)] and his dramatic work which is coming.
Exemple au service de la spiritualité conjugale : les couples royaux dans « Le Livre de la vertu du sacrement de mariage » de Philippe de Mézières
Authors: Loba Anna
Published: December 2024

The reading of the didactic works dedicated to the feminine public at the end of the Middle Ages teaches us that their authors treat the marriage as a natural vocation of the woman and although they are not indifferent to the religious dimension of the conjugal reality, it is the terrestrial and profane aspect that interests them more. So the works such as the Livre pour l'enseignement de ses filles of Geoffroy de La Tour Landry, Mesnagier de Paris and even Le Livre des Trois Vertus of Christine de Pizan appear in the form of textbooks in which the women can find any sort of rules, even practical advice on how to become a good wife and how to make a successful marriage. Among these books concerning the conjugal savoirfaire, the treaty of Philippe de Mézières Le Livre de la Vertu du sacrament de marriage et reconfort des dames mariés (1385-1389) occupies a very particular place. At first because the material sphere and everyday life of the life of a couple interest him only marginally, then because he turns all his attention to the essence of the marriage. Through his return in the spiritual conceptions of the marriage Philippe de Mézières anticipates his time. By putting in the heart of the marriage the love, by putting the love as the foundation of the marital union, he contributes to the advent of the modern couple which will triumph only after the Council of Thirty.
Peripartum COVID-19 & hemophagocytic lymphohistiocytosis: a case report
Authors: Mostajeran Kathy , Rabulinksi Daniel , Khan Abdul , Sher Nehan , Huls Christopher K. , Oh Chien C.
Published: December 2024

Objectives

Hemophagocytic lymphohistiocytosis (HLH) is a rare disorder of hypercytokinemia and immune dysregulation. Most commonly diagnosed in the pediatric population due to genetic predisposition, the condition can manifest in the adult population secondary to an immune dysregulating event, such as infection, malignancy, rheumatologic disorders, immunodeficiency, and checkpoint inhibitors. The presentation and diagnosis during pregnancy are extremely rare and elusive. We present a case of secondary HLH during the peripartum period, urging obstetrical providers to keep the condition as part of their differential diagnosis.

Case presentation

A 20-year-old Gravida 1, with a past medical history significant for non-alcoholic hepatosteatosis and morbid obesity, presented multiple times to the emergency department in the third trimester with liver function test derangements and vague complaints of subjective fevers and fatigue. She eventually tested positive for COVID-19. Two weeks after the initial presentation, she went into spontaneous preterm labor and delivered. Postpartum, her liver dysfunction worsened in association with high fevers and persistent tachycardia. After an extensive workup failed to reveal an etiology, HLH was suspected. Labs were sent for confirmation, and she was initiated on pulse-dose steroids. However, the patient acutely decompensated and succumbed to the disease. Several days later, labs resulted, confirming the diagnosis of HLH.

Conclusions

In peripartum patients presenting with severe derangements in liver function tests and vague symptoms with undulating episodes of pyrexia, HLH should be considered early as part of the differential diagnosis. This is particularly true when antibiotics or postpartum status fail to alleviate the symptomatology or improve the clinical course.
Influence of the COVID-19 pandemic on the amputation rate in Germany in patients with critical limb-threatening ischaemia
Authors: Derwich Wojciech , Schöffski Oliver , Herrmann Eva , Oikonomou Kyriakos
Published: December 2024

Objectives

The COVID-19 pandemic has shown a wide range of direct and indirect influences on the health of the population. This study examines the impact of the COVID-19 pandemic on the amputation rate in Germany in patients with critical limb-threatening ischaemia (CLTI).

Methods

The epidemiological, pooled, and anonymised data of 476,168 CLTI patients from the Institute for the Hospital Remuneration System (InEK) were analysed for 2019–2023 at the federal level at weekly intervals and compared with epidemiological data for COVID-19 patients from the Robert Koch Institute (RKI) database, divided into the pandemic phases.

Results

The number of inpatient cases declined by −4.64 % (p>0.05) from 2019 to 2020 and increased significantly by +7.07 % (p=0.001) from 2020 to 2023. The incidence of all lower limb amputations increased from 2019 to 2022 (23.9 vs. 25.7 %, p=0.01) with no significant changes in 2023. Moreover, the incidence of minor amputations increased from 16.9 % in 2019 to a maximum of 18.9 % (p<0.001) in 2022, and then to 18.4 % (p=0.02) in 2023. In the short-term perspective, inpatient cases significantly decreased in phases 1 and 3, with a relevant increase in the subsequent phases. However, the incidence of all amputations, especially minor ones, is constantly increasing.

Conclusions

The COVID-19 pandemic has significantly indirectly impacted the management of CLTI patients, with a marked increase in the incidence of minor amputations, presumably due to the delayed presentation of patients with small necroses and due to limited access to healthcare.
Some results on uniqueness and higher order difference equations
Authors: An Jia , Zhang Haiying , Wang Ge , Fang Mingliang
Published: December 2024

In this article, we mainly study the solution of higher order difference equations. We solve some questions posed by Chen and Xu [Uniqueness on entire functions and their nth order exact differences with two shared values, Open Math. 18 (2020), no. 1, 211–215] and give a negative answer to some conjectures posed by Gao et al. [Uniqueness of meromorphic functions sharing values with their nth order exact differences, Anal. Math. 45 (2019), no. 2, 321–334] and Ahamed [Class of meromorphic functions partially shared values with their differences or shifts, Kyungpook Math. J. 61 (2021), no. 4, 745–763]. Meanwhile, we extend some results due to Adud and Chakraborty [Some results related to differential-difference counterpart of the Brück conjecture, Commun. Korean Math. Soc. 39 (2024), no. 1, 117–125].
Fluoxetine inhibited RANKL-induced osteoclastic differentiation in vitro
Authors: Zhang Jing-wen , Zhao Fang-bing , Ma Bing’er , Shen Xiao-qing , Geng Yuan-ming
Published: December 2024

Selective serotonin reuptake inhibitor correlates with decreased bone mineral density and impedes orthodontic tooth movement. The present study aimed to examine the effects of fluoxetine on osteoclast differentiation and function. Human peripheral blood mononuclear cells (hPBMCs) and murine RAW264.7 cells were cultured with RANKL to stimulate osteoclast differentiation. The resulting multinucleated cells displayed characteristics of mature osteoclasts. Fluoxetine at 0.01–1 μM did not impact cellular viability or oxidative stress. However, 10 μM fluoxetine significantly reduced clonal growth, cell viability, and increased cytotoxicity and lipid peroxidation in RAW 264.7 cells. Further, application of 0.1 μM fluoxetine potently suppressed osteoclast differentiation of both RAW264.7 and hPBMCs, with reduced osteoclast numbers and downregulation of osteoclastic genes matrix metalloproteinase-9, cathepsin K, and integrin β3 at mRNA and protein levels. Fluoxetine also disrupted F-actin ring formation essential for osteoclast resorptive function. Mechanistically, fluoxetine inhibited NF-kB signaling by reducing phosphorylation of pathway members IκBα and p65, preventing IκBα degradation and blocking p65 nuclear translocation. In conclusion, this study demonstrates fluoxetine suppressing osteoclast differentiation in association with disrupting NF-kB activation, providing insight into orthodontic treatment planning for patients taking fluoxetine.
Controlling pore size during the synthesis of hydroxyapatite nanoparticles using CTAB by the sol–gel hydrothermal method and their biological activities
Authors: Jayakodi Santhoshkumar , Shanmugam Rajeshkumar , Pandian Elumalai , Govindasamy Mani , Asiri Jaber M. , Yadav Krishna Kumar , Ryeol Choi Jeong
Published: December 2024

Nanorod and nanosphere hydroxyapatite (HAP) particles were synthesized by the sol–gel hydrothermal method. The size of the synthesized HAP nanoparticles was controlled using cetyltrimethylammonium bromide (CTAB) as a templating agent with molar concentrations (HAP + 0.01 M CTAB, HAP + 0.03 M CTAB, and HAP + 0.1 M CTAB). The purity, size, shape, and elemental composition of HAP were determined using powder X-ray diffraction (XRD), Fourier transform infrared spectroscopy, field emission scanning electron microscopy, and transmission electron microscopy, which enabled us to determine the nanostructure formation. Further, Brunauer–Emmett–Teller analysis of the samples proves the size of the pores to be 7–10 nm. Thus, by altering the concentration of CTAB, HAP nanorods were induced along the c-axis. The zeta potential values of −34.7 and −28.7 mV confirmed the stability of pure HAP and HAP + 0.01 M CTAB. Further, the biological activities of the HAP nanoparticles were determined. In the anti-microbial activity test, an increase in the inhibition with an increase in the concentration of pure HAP to 0.1 M CTAB + HAP was observed against S. aureus, S. pyrogens, B. subtilis, E. aerogens, K. pneumoniae, and P. vulgaris. About 76% of antioxidant activity was obtained from the experiments. The drug-release behavior of doxorubicin-loaded pure HAP and CTAB-coated HAP also indicates that the % of drug delivery depends on the pores, which further depends on the CTAB concentration. The cytotoxic assay also revealed potential inhibitory effects against human cancer cell lines (MCF-7), with 65% cell viability recorded at a concentration of 500 μg/ml. These findings indicate that the pore size and shape of HAP play significant roles in their biological activities.
Vietnamese tense marking since the seventeenth century: A historiographical analysis
Authors: Le Quang Anh
Published: December 2024

This article investigates the historical development of the linguistic writings on Vietnamese tense marking. The scholarship on Vietnamese tense marking is unique as it is shaped by both linguistic and non-linguistic influences: foreshadowed in the seventeenth-century missionary grammars, turned prescriptive during the French colonisation of Vietnam, bifurcated during the Cold War, and since 1986 converged with rapid developments in tense-aspect-mood (TAM) theories. In this article, I critically examine and (re-)interpret the claims on Vietnamese tense marking made by the relevant grammatical writings during these periods and consolidate the scholarship into three emerging themes: transcategorial complexity; covert–overt complexity; and prevalence of TAM. I show that TAM theories have predominantly been the only theoretical framework for analysing a group of multifunctional particles. This prevalence of TAM theories arises not only because (i) how each of the earlier grammars of Vietnamese on the topic was referenced, misinterpreted, or ignored due to certain historical and socio-political milestones, but also because (ii) the influence of certain linguistic ideologies overshadows the other two themes and ultimately the pragmatic functions of those particles. These two reasons form a unique scholarship on Vietnamese tense marking, the basis of which is grounded firmly on continuously expanding TAM theories.
Propagation of optical spatial solitons in nematic liquid crystals with quadruple power law of nonlinearity appears in fluid mechanics
Authors: Yousaf Muhammad Zain , Abbas Muhammad , Lupas Alina Alb , Abdullah Farah Aini , Iqbal Muhammad Kashif , Alharthi Muteb R. , Hamed Yasser S.
Published: December 2024

The present research explores nematicons in liquid crystals (LCs) with quadruple power law nonlinearity utilizing the modified extended Fan sub-equation technique as an analytical tool to investigate the optical spatial soliton solutions. For the inaugural time, a novel version of nonlinearity is investigated in relation to LCs. There are distinct applications for the several wave solutions that have been created in optical handling data. The aforementioned modified extended Fan subequation approach offers novel, comprehensive solutions that are relatively easy to deploy in comparison to earlier, regular methodologies. This approach translates a coupled non-linear partial differential equation into a coupled ordinary differential equation through implementing a traveling wave conversion. This approach indicates that a large variety of traveling and solitary solutions that rely upon five parameters can be incorporated by the nematicons in LCs. In addition, the investigation yields solutions of the single and mixed non-degenerate Jacobi elliptic function form. Novel solutions, such as the periodic pattern, kink and anti-kink patterns, N-pattern, W-pattern, anti-Z-pattern, M-pattern, V-pattern, complexion pattern and anti-bell pattern, or dark soliton solutions of nematic LCs, have been constructed by means of modified extended Fan subequation technique through granting suitable values for the parameters. The computer software Mathematica 14 is used to illustrate several modulus, real and imaginary solutions visually in the form of contour, 2D, and 3D visualizations that help understand the concrete importance of the nematicons in LCs. This research additionally offers a physical comprehension of the obtained solutions and applications of model. The imposed approach is ultimately thought to be more potent and effective than alternative approaches, and the solutions found in this work could be beneficial in our understanding of soliton structures in LCs.
Computational approaches for structural analysis of wood specimens
Authors: Chakkour Tarik
Published: December 2024

The structure tensor (ST), also named a second-moment matrix, is a popular tool in image processing. Usually, its purpose is to evaluate orientation and to conduct local structural analysis. We present an efficient algorithm for computing eigenvalues and linking eigenvectors of the ST derived from a material structure. The performance and efficiency of our approach are demonstrated through several numerical simulations. The proposed approach is evaluated qualitatively and quantitatively using different two-dimensional/three-dimensional wood image types. This article reviews the properties of the first- and second-order STs, their properties, and their application to illustrate their usefulness in analyzing the wood data. Our results demonstrate that the suggested approach achieves a high-quality orientation trajectory from high-resolution micro-computed tomography (

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CT)-imaging. These orientations lead to establishing a description of fiber orientation states in thermo-mechanical models for fiber-reinforced composite materials. We conclude with an overview of open research and problem directions.
Prevalence of substance use disorder diagnoses in patients with chronic pain receiving reimbursed opioids: An epidemiological study of four Norwegian health registries
Authors: Nøst Torunn Hatlen , Skurtveit Svetlana , Odsbu Ingvild , Pedersen Line , Borchgrevink Petter C. , Handal Marte
Published: December 2024

Objectives

Since 2008, patients have had access to reimbursed analgesics, including opioids, for chronic pain in Norway. There is a need for knowledge on the occurrence and trends over time of substance use disorder (SUD) diagnoses among patients who receive reimbursed opioids for chronic pain. The primary aim of this study was to investigate the prevalence of SUD diagnoses in patients with chronic pain using reimbursed opioids from 2010 to 2019 in Norway. The secondary aim was to investigate the prevalence of other mental health diagnoses among those receiving reimbursed opioids in the subgroups with and without SUD diagnoses.

Methods

A cross-sectional design utilising data from four Norwegian nationwide registries.

Results

The annual number of individuals with SUD diagnoses increased from 377 to 932 from 2010 to 2019, while the annual prevalence of individuals with SUD remained relatively stable at around 5%. There was a higher prevalence for all categories of other mental health diagnoses among individuals with a SUD diagnosis, compared to those without a SUD diagnosis.

Conclusion

The prevalence of SUD diagnoses was low in the population using reimbursed opioids for chronic pain in Norway, but the number of patients increased in the study period because the number of individuals receiving reimbursed opioids increased. Patients with a SUD used on average twice the daily doses of opioids compared to patients without a SUD. They were also more likely to have an additional mental health diagnosis.
Andamios: veinte años
Authors: Romero Chumacero Leticia
Published: December 2024

El objeto de este artículo es ofrecer un balance del trabajo académico producido durante veinte años por Andamios. Revista de Investigación Social de la Universidad Autónoma de la Ciudad de México (UACM), y exponer algunos de sus retos.
Repetitions in Reserve: An Emerging Method for Strength Exercise Prescription in Special Populations
Authors: Maroto-Izquierdo Sergio , López-Ortiz Susana , Peñín-Grandes Saúl , Santos-Lozano Alejandro
Published: December 2024

This review briefly outlines the benefits and limitations of traditional methods for prescribing resistance training (RT) exercise intensity (i.e., the percentage of 1 repetition maximum, velocity-based training, and rating of perceived exertion) for special populations based on mechanical and psychological indicators. Given these limitations, the repetition in reserve (RIR) method, which quantifies the discrepancy between potential and actual repetitions, has been proposed as a safer, more effective, and adaptable alternative to optimize RT in special populations. This study provides an overview of the main RIR scales used in scientific literature and synthesizes RIR validation studies. Although the validity and reliability of the RIR method have not been extensively tested across different special populations, and a scarcity of studies applying it in clinical contexts has been detected, this review proposes a practical application that integrates existing scales for prescribing RT in rehabilitation settings and for individuals with chronic health conditions. In conclusion, the RIR method shows promise for broader application in clinical settings, and further research is needed to validate its effectiveness in diverse population groups.
Back to Block: Re-imagining student learning in a hyper-connected world through an international academic conference
Authors: Goode Elizabeth , Blair Alasdair
Published: December 2024

This article reflects on the International Block and Intensive Teaching Association (IBILTA) conference held in Melbourne, Australia, in July 2024. Perspectives are offered from two delegates who joined the conference from differing institutional and national contexts. One is a Teaching Scholar from Southern Cross University, Australia, and the other an Associate Pro Vice-Chancellor from De Montfort University, UK. We reflect on the value of attending the conference in person, some of the challenges, and offer thoughts on ‘where to next’.
A escrita de /an/ por pré-escolares: pistas acústico-auditivas
Authors: Berti Larissa Cristina , Chacon Lourenço , Santos Alessandra Pagliuso dos
Published: December 2024

A proposta do presente estudo foi a de verificar: (i) em que medida as crianças registram o fonema /a/ em contexto de nasalização; (ii) em caso de registros, que tipos de registros, convencionais ou desviantes, as crianças utilizaram para marcar tal fonema; e (iii) buscar possíveis vínculos entre os registros escritos utilizados pelas crianças e características acústico-auditivas que estes registros poderiam indiciar. A partir de um corpus constituído de 20 textos de crianças pré-escolares envolvendo a grafia de /aN/ em 08 palavras – computando um total de 160 possibilidades de ocorrência, constatamos que as crianças registraram o fonema /aN/ em 127 palavras (79%). No entanto, a maioria desses registros (86%) não estava de acordo com as convenções ortográficas. Destaca-se que dentre os registros desviantes, o registro do elemento vocálico esteve presente em 94%. Esse fato pode ser explicado em termos auditivo-perceptuais, uma vez que as características formânticas da vogal são favorecidas pelo aparelho auditivo humano. Nossos resultados apontaram para uma forte ancoragem das crianças em informações denatureza acústico-auditiva da fala em seu processo de aquisição da escrita.Palavras-chave: Aquisição da escrita; Ortografia; Nasalidade. Pre-scholars writing of the phoneme /a/: acoustic-hearing cues.AbstractThe aims of this study were: (i) verified in with measure the children record the /a/ phoneme in nasalization context (ii) in case of records, which type of writing record, conventional or deviant, the children used to mark such phoneme; (iii) to search for possible links between the written records used by the children and the hearing-acoustical cues that these records might indicate. The analysis was realized from of a corpus constituted by 20 prescholars’ texts showing the writing of /aN/ in 08 words adding up to 160 tokens. We verified that the children wrote the phoneme /aN/ in 127 words (79%). Conversely, most of the writings (86%) were deviant records. In addition, the vocalic writing was present in 94% of the deviant records. That occurrence may be explained in perceptual-hearing te rms once the vocalic characteristics are enhanced by the hearing system. The outcome suggested that the children have a strong support on hearing-acoustical cues of speech during writing acquisition.Keywords: writing acquisition; orthography; nasality.
Cadernos de Educação Nº 36
Authors: Del Pino Mauro Augusto Burkert
Published: December 2024

A Cadernos de Educação tem buscado contribuir com o debate contemporâneo através da publicação de artigos que expressam preocupações teóricas e metodológicas em torno dos principais temas da educação e de áreas correlatas. Nesta edição, damos sequência a nossa política editorial, apresentando mais uma revista temática, composta de duas seções.
Formação de professores de surdos: dispositivos para garantir práticas discursivas
Authors: Vieira-Machado Lucyenne Matos da Costa
Published: December 2024

Este ensaio tem como objetivo pensar sobre as questões que sinalizam para uma formação de professores de surdos bilíngues (ouvintes ou surdos) capixabas, condizente com as práticas discursivas sobre surdos, surdez e sobre a inclusão que é vigente na época em que se situa. Também quer localizar as questões políticas relacionadas à perspectiva de sujeito nesse processo de concepção social. Para tal análise, escolhi algumas propostas de formação do MEC para o professor especialista na área da surdez, inclusive realizadas no estado do Espírito Santo, mostrando a trajetória de mudanças de concepções e mudanças de discursos sobre a educação de surdos nas formações de professores.Palavras-chave: Formação; professores bilíngues; educação de surdos. Training for teachers of the deaf: procedures to guarantee discursive practicesAbstractThis assay has as aim the thinking about the questions which signalling to a formation of bilingual for deaf teachers (listener or deaf) in Espírito Santo State, consistent with the discursive preactices about hearing impaired, deafness and about the inclusion that is current in the time when it takes place. It also wants to locate the political questions related to the perspective of subject in this processess of social conception. For such analysis some proposals of formation of MEC to the professor specialized in the deafness area, including the ones performed in the state of "Epirito Santo", showing the trajectoryn of changes in the conception and in the speech about hearingimpaired education in the formation of professors.Key words: Shaping of teachers; bilingual teachers; hearing impaired education.