bluuebunny/crossref_metadata_2025 huggingface dataset:
Need analysis for geriatric care services in a tertiary care teaching hospital: a patient perspective analysis
Authors: Yathindra Chitra , D’Souza Sonia E.
Published: March 2024

Background: In India, aging population is increasing every year. So, healthcare industry needs to set up a geriatric unit soon. Development of geriatrics and old-age care systems in India will make elderly people independent and improve their lifestyle, life expectancy, and quality of life while decreasing the cost of care. This study looks at the views of patients who are 60 years or older, as well as need for a full-fledged geriatric unit in a tertiary care hospital.
Methods: This study used questionnaires to get information from patients about the need for a geriatric care service in the chosen tertiary care teaching hospital. The study was conducted between March 2022 to July 2022
Results: Over 96% of the patients opined that elderly patients require a separate health care setup from the regular health care system. The study showed that 69.9% of the patient respondents opined that they require an attendant each time they visit a hospital. Also, 51.6% of the patients did not go to their doctor's appointments because they needed someone to accompany them to the hospital.
Conclusions: A study shows that older people rely on family members to check out healthcare facilities. If a new geriatric unit has the latest facilities, 96.8% of the patients will take advantage of them. Hence, a well-established geriatric department in the selected hospital is the need of the hour.
A cross-sectional study to assess medical student’s opinions regarding child sexual abuse in an Eastern state of India
Authors: Rastogi Ashok Kumar , Debbarma Shibajee
Published: March 2024

Background: Child sexual abuse (CSA) is a heinous crime against growing children, which may victimize both genders. It is a pervasive issue that affects societies worldwide. Present study was conducted to gain insights into the opinion and understanding regarding CSA among undergraduate medical students at a premier institution in Bihar, an Eastern state of India. Objectives were to study the distribution of medical students according to opinions regarding CSA and to study the distribution of medical students according to information regarding CSA obtained from parents.
Methods: After obtaining institutional ethical committee (IEC) clearance, a pre-designed structured questionnaire was administered online to undergraduate medical students of the institution who gave consent for study. Collected information was entered in Microsoft excel, and categorical variables were expressed as percentages and proportions.
Results: The present study included 312 boys (62.4%) and 186 girls (37.6%). The majority (82.2%) of study participants agreed that boys are also victims of CSA, and the majority (68.3%) agreed with the statement regarding informing a caregiver following an incident. Most (64%) of the study participants had obtained information regarding CSA from parents.
Conclusions: Awareness generation is an important measure to curb the growing menace of CSA. Parental education plays a vital role in creating necessary awareness.
Magnitude and pattern of multimorbidity among adult patients attending a primary care setting in Delhi, India
Authors: Pandey Priyanka , Acharya Anita S. , Laskar Ananya R.
Published: March 2024

Background: Multimorbidity, “the coexistence of two or more chronic diseases”, is an upcoming & less addressed public health challenge for low and middle-income countries undergoing rapid demographic and epidemiological transition. This study was done to estimate the burden & pattern of multimorbidity in adults (≥18 years) in a primary care setting.
Methods: This cross-sectional study was carried out from January 2021 to March 2022 at a primary health centre in South Delhi. Data was collected by conducting exit interviews with 510 adult patients using a self-designed, pre-tested interview schedule. Data was analyzed using SPSS and Microsoft Excel.
Results: Out of 510 study subjects interviewed, the overall magnitude of multimorbidity was 160 (31.4%). Almost half of the study subjects with multimorbidity had dyads, one-third had triads, and the rest had quadrads multimorbidity patterns. The leading triad was diabetes mellitus+hypertension+heart disease (12.3%), followed by diabetes mellitus+hypertension+chronic lung disease (10.5%). More than half of the study subjects with multimorbidity, 89 (55.6%), suffered from concordant MM.
Conclusions: The study revealed that 31.4% of subjects had multimorbidity, which was almost equally distributed across the age groups. The burden was significantly higher among those aged 18-39 years. Hypertension and Heart disease were found to be the most frequent and the most concordant multimorbidity, respectively, associated with Diabetes mellitus.
COVID-19 vaccination: disease status and outcomes of COVID-19 patients admitted in tertiary care hospital in Raigad District of Maharashtra
Authors: Pedhambkar Ratnaprabha B. , Salgotra Kuldip R. , Bhusare Dattatray B.
Published: March 2024

Background: COVID-19 pandemic had witnessed serious infections and deaths during third wave of the pandemic. This study was designed to analyse the association between severity of disease and patient outcomes with vaccination status of COVID-19 patients.
Methods: Retrospective record-based study was conducted among 258 COVID-19 patients from August 2021 to January 2022, during the third wave of the pandemic in a tertiary care hospital.
Results: Out of the 258 patients, 42% patients were above 60 years of age 19% were in the age group of 18-30 years. 58% male and 42% female patients. Overall, 50% and 36% patients above 40 years had severe and moderate disease respectively. 52% had mild disease in age group of 18-30 years and this was statistically significant with Chi-square value of 38.85 and p<0.05. 36%, 36% and 28% vaccinated patients had severe, moderate and mild disease respectively. 38%, 40% and 23% unvaccinated patients had severe, moderate and mild disease respectively. The mortality rate was 25%, 32% and 50% among vaccinated, unvaccinated and unknown vaccination status respectively. The mortality rate was 44% in those above 60 years. The survival rates were 90% in patients below 40 years. This difference was statistically significant with Chi-square value of 32.16, p<0.005. The mortality rate was 61%, 16% and 2% with severe, moderate and mild disease respectively.
Conclusions: The severity and mortality rate was less in vaccinated patients. This shows that vaccination might be effective in reducing the severity of disease and deaths among COVID-19 patients.
An evidence-based tuberculosis patient’s nutrition assessment tool and intervention guidelines for DOTS providers: a modified Delphi study
Authors: A. S. Vishwas , Ajmera Vijayamma , Goswami Yogeshwar Puri
Published: March 2024

Background: An individual's nutritional state is an indicator of their overall health. Poor nutrition, under nutrition, vitamin deficiency and protein energy malnutrition a form of nutritional problems. In low and middle-income countries, the linkage between infectious diseases such as tuberculosis and under nutrition is critical to public health. Thus, the current study aims to explore the DOTS Providers' concerns and develop evidence-based tuberculosis patient’s nutrition assessment tool and intervention guidelines for DOTS providers, which can be quick and easy to assess.
Methods: A modified Delphi process was used to develop the nutrition assessment tool and intervention guidelines through mixed-method approach. Three rounds of the Delphi process were carried out via email, with a letter requesting to participate in the Delphi process.
Result: An in-depth interview schedule was conducted to extract themes and subthemes generating an item pool in the initial phase. The main themes identified were Perception of disease, TB cure, Association of under nutrition and TB management, Problems or difficulties encountered, Counsel, Assessment and intervention. Quantitative data analysis was performed manually by calculating the content validity index (CVI). The CVI was found to be >80% for all the items with I-CVI≥0.8 and S-CVI≥0.9. All the items were considered very essential with a score of 1.
Conclusions: The assessment tool should be subjected to other levels of evaluation that measures the suitability of the tool and interventional guidelines for the intended field.
Nutritional status assessment of 6-59 months age children in rural Yadgir, Karnataka state, India
Authors: Chittapur Dhanaraj , Patil Shilpa S. , Lakshmanappa Shruthi
Published: March 2024

Background: Childhood undernutrition contributes to childhood diseases and is a major cause of child mortality in India. According to National Family Health Survey (NFHS-5), 32% under-five children in India were under-weight, and 36% were stunted. In Karnataka, the prevalence of underweight among under-five children was 33% and stunting 35%. The objective of the study was to assess the nutritional status of under five-years children in rural communities.
Methods: A community based cross sectional study was conducted among 1887 under-five children from rural Yadgir, Karnataka. Weight and height of children were measured using standard protocols. The World Health Organization (WHO) Anthro software version 3.2.2.1 was used for analyzing data. Children whose Z-scores on weight-for-age, height-for-age and weight-for-height indices were below -2SD from the median of the WHO reference population were considered as underweight, stunted, and wasted respectively.
Results: The result revealed that 53.6% of children were stunted, 39.4% were underweight and 15.3% were wasted. Severe forms of underweight, stunting and wasting were observed among 9.4%, 24.2% and 4% children respectively. The frequency of being underweight and stunted has increased with age, which was accelerated after 6 months and about 34% and 52% of children were underweight and stunted by the age 12-23 months. While wasting was higher among children aged 6-11 (24.2%) months than their counterparts.
Conclusions: Special attention is required to reduce nutrition vulnerability among young children (12-24 months). An appropriate strategy needs to be implemented to educate rural mothers on the importance of exclusive breastfeeding and complementary feeding practices.
A study on nutritional status of preschool children and knowledge with special references to breastfeeding practice in urban area
Authors: Birajdar Shrikant S. , C. S. Jayalekshmi , Jadhav Bhimrao S. , Nagaonkar Ajit S.
Published: March 2024

Background: The nutritional status of preschool children is a critical indicator of their overall health and development. Breastfeeding provides best start of life to babies as well as improves the health of mothers and babies. Objectives were to assess the nutritional status of preschool children and to Investigate the impact of breastfeeding practices on children’s nutritional outcomes and breastfeeding practices of their mothers.
Methods: This cross-sectional study was conducted in an urban slum area and involved a sample of preschool children aged 3 to 6 years. Complete enumeration of children of 3-6 years age group was done. Nutritional status was assessed through anthropometric measurements, including height, weight and mid upper arm circumference. Data on breastfeeding practices were collected through structured interviews. Data was analysed using MS excel and chi-square statistical tests was applied.
Results: There were 334 study participants of which 7.5% had stunting and 62.87% were underweight. It was found that 18.56% had history of low birth weight. 90.12% were exclusively breastfed and breastfeeding was continued up to 2 years for 28.14% and more than 2 years for 71.86% children. It was also found that history of low birth weight of children is significantly associated with malnourishment (p≤0.05).
Conclusions: The study revealed that a substantial proportion of preschool children in the urban area were experiencing malnutrition. The breastfeeding practices were fair among the mothers of the children. Targeted education and awareness programs to enhance the nutrition can improve the overall health of preschool children in the urban setting.
Current role of viral biomarkers in cervical carcinogenesis
Authors: Daniel Akshatha , Daniel Shriyaa , Nagandla Kavitha
Published: March 2024

Viral biomarkers for cervical cancer screening are valuable in improving timely diagnosis and detection at early stage. The various biomarkers currently there is evidence include high-risk human papillomavirus (hrHPV) deoxyribonucleic acid (DNA) testing, there is place for further research for biomarkers such as hrHPV genotyping hrHPV transcriptional status, and host DNA methylation. Though the evidence is conclusive for hrHPV DNA testing, there is place for further research for biomarkers such as hrHPV genotyping hrHPV transcriptional status, and host DNA methylation. This application of these biomarkers in context of low resource settings has its limitations despite high prevalence of the disease. Improved women participation can be achieved by use of self-samples thereby improving diagnoses rate of the disease and higher cost effectiveness of the screening programme. In due course, biomarkers will be made available in the screening programmes together with self-sampling that will detect hrHPV infections and low-grade squamous intraepithelial lesions (LSIL) before they progress to high-grade squamous intraepithelial lesions (HSIL), and from there to malignancy. This would facilitate prudent timely clinical decisions, reduced patient anxiety, reduction in over referral and unnecessary treatments in women, especially in developing countries.
Does ranibizumab biosimilars fare as well in macular neovascularisation?
Authors: Iqbal Sameer , Soman Manoj , Nair Indu J , Ravi R V  , Nair Unnikrishnan
Published: March 2024

To evaluate the effectiveness and safety profile of Ranibizumab Biosimilar in Macular Neovascularisation and compare outcomes with patent Ranibizumab.

A retrospective analysis during the period 2017-2020 was conducted at a tertiary eye care centre in South Kerala on patients with wet AMD who had received Razumab, a biosimilar of Ranibizumab as a loading dose followed by PRN schedule. This was compared to a similar data obtained from patented Ranibizumab (Lucentis) during the same period. Endpoints analyzed included improvement in BCVA, proportion of patients with persistent IRF/SRF and complications at 1 year.

Of 164 eyes analyzed 76 eyes received Razumab and 88 eyes received Lucentis with 32% and 50% males in each group. After the loading dose both drugs showed similar efficacy and the final vision (median logmar; 0.24 vs 0.17; p 0.189), presence of residual CME (31.6% vs 18.2%; p 0.469) and SRF (57.9% vs 61.9%; p 0.796) were similar in both groups at 12 months. The mean number of injections was 8 in the Razumab group comparable to Lucentis (6.4). Acceptability and less drop outs were seen in Razumab patients compared to Lucentis. Though some eyes developed mild uveitis (4.3%) with one of the initial batches of Razumab, it was not evidenced later. No other safety concerns or side effects were reported with the biosimilar.

The Biosimilar Razumab is as effective as the patent molecule in reducing macular fluid and improving visual acuity in patients with macular neovascularization over 1 year on a PRN schedule. Being cheaper it is a safe alternative for patients who often need long term management.
A cross-sectional study to compare the regional corneal thickness profiles in various age groups of Saudi population using 7 mm wide optical coherence tomography scans
Authors: Alrashidi Sultan
Published: March 2024

Measuring age-matched normative corneal thickness (CT) values in the center and peripheral regions can be useful in clinical practice. To determine the influence of age and gender on the central, paracentral and mid-peripheral corneal pachymetry profile in normal eyes using spectral domain optical coherence tomography (SD-OCT); and to estimate the average regional CT profiles across all the age groups.

Five ninety-six healthy eyes of 298 subjects aged between 10 and 98 years were evaluated using REVO FC anterior segment SD-OCT with predefined concentric corneal ring-shaped zones. CT was calculated in 17 sectors within a central 7-mm circle. Central zone CT (CCT: 2mm), paracentral (PCT: 2 to 5-mm), and midperipheral (MPCT: 5 to 7-mm) in the superior, superior temporal, temporal, inferior temporal, inferior, inferior nasal, nasal and superior nasal cornea; minimum, maximum, median thickness within the 7-mm diameter area were recorded. The mean CT in corresponding zone was compared between genders and correlations with age were evaluated.

The distribution of CCT was 537.9±38µm with no significant difference between right and left eyes, or between males and females CCT. No significant difference noted between male and female participants with respect to age, and no interocular asymmetry in CT was identified either in paracentral or midperipheral zones (17 sectors). The PCT was 1.6% to 5.2% thicker whereas the MPCT sector was 2.3% to 11.4% thicker than the CCT, with the paracentral and midperipheral sectors’ superior and superior nasal zones were the thickest zones in the normal population. The mean paracentral inferior temporal (537.9±38.0) and temporal (538.7±37.2) zones’ CT were similar to mean CCT-2mm (537.7±36.3). CT varied with age in the seven groups of both genders, specifically in the paracentral and mid-peripheral zones. CT decreases, but its dependence on age is weaker. The CT increased gradually from the center to midperipheral ring with the superior and superior nasal regions had the thickest CTs, while the thinnest points are located primarily in the temporal and inferior temporal cornea.

With the help of SD-OCT, this is the first study establishes the normative central, paracentral, mid-peripheral, and minimum CT data, which differ significantly from Saudi Arabians in location and magnitude. Based on the results, decisions regarding refractive surgery and corneal diagnosis can be made.
Study on the association between total vitamin D levels and diabetic retinopathy in type 2 diabetic mellitus
Authors: Kuruvila Magna Mary , Biradar Sunil
Published: March 2024

This study aims to recognize the interrelation among total vitamin D levels and diabetic retinopathy in diabetic mellitus particular type 2 variant.

That was a cross-sectional look on 276 patients with diabetes mellitus. Cases were grouped similarly into with and without DR.

Screening tactics like unique records, best-corrected visual acuity, fundoscopic examination, and blood investigations like fasting blood sugar, post prandial blood sugar, HbA1C vitamin-D were carried out. Diabetic retinopathy is graded the use of ETDRS.

The relation of the period of diabetes to the severity of retinopathy showed an advantageous correlation, with a p-value <0.001. It has confirmed an inverse relationship among the severity of diabetic retinopathy and Vitamin D values. Sufferers with mild NPDR and moderate NPDR had Vitamin D insufficiency, which decreased to Vitamin D deficiency stages in severe NPDR and PDR.

A relation change is observed among diabetic retinopathy and total Vitamin D levels. Henceforth, it is important to examine the affiliation of Vitamin D with the extent of DR, its use to forecast of the severity of DR, and as a device to restrict or prevent the development of retinopathy modifications.
Comparative assessment of pupillary oscillation and blinking rate between emmetropes and myopes
Authors: Dash Shovna , Soumya Kanta Mohanty  , Sahu Pallavi Priyadarshini , Padhee Sourav
Published: March 2024

Aim of this study was to investigate for a relationship between pupillary oscillations (PO) and blinking rate (B) in various vision deprived states such as in refractive errors (Myopes).

: A case control descriptive study with 340 individuals, including 220 myopes and 120 emmetropes were compared for pupillary oscillation rate (PO), blinking rate (B) and Pupillary oscillation/blinking rate (PO/B) ratio bilaterally in normal as well as in individual subgroups of decreasing visual acuity, done under slit lamp in dim diffuse illumination.

The pupillary oscillation rate (PO) was 49.23± 8.80 in right eye (POR) and 56.44 ±8.95 in left eye (POL) in the control group whereas it was 46.28 ±11.55 and 52.79 ±11.22 in the right and left eyes respectively of the cases. While PO/B ratio was 12.41±14.11 in the right eye and 14.33±15.9 in the left eye in control group, it was 7.13 ± 7.86 in the right and 8.18 ±9.07 in the left eye of the cases respectively. The blinking rate (B) was 8.62 ±6.06 in the control eyes and in the cases it was 11.69 ±7.91. The comparative analysis of all of the above parameters were statistically significant with p < 0.001 between cases and controls. POR = POL in 5.0%, POR > POL in 7.50% and POR < POL in 87.50%.

: This study could be useful in non-verbal patients and comatose patients as diagnostic and prognostic tool, having an implication in different refractive errors and neurological diseases.
Clinical assessment of corneal alterations in endocrine disorders
Authors: Behera Sharmistha , Sahu Biswanath , Tudu Kanhei Charan , Singh Sonali
Published: March 2024

Corneal alterations are frequent in many endocrine disorders like Grave’s ophthalmopathy and diabetes mellitus. Since early diagnosis of such a change can prevent visual impairment, it presents a challenge to an ophthalmologist.

Clinical assessment & significance of corneal alterations in endocrine disorders.

1. To conduct comprehensive assessment of corneal alterations in endocrine disorders. 2. To Identify specific corneal abnormalities in patients with endocrine disorders. 3. To delineate the clinical significance of corneal alterations in endocrine disorders by determining their impact on visual function and guiding therapeutic strategies.

This study was a prospective, observational, hospital-based study conducted over a period of two years including 150 patients of different endocrine disorders. Ocular examination included physical examination to check for any pain on ocular movements, ophthalmoplegia, diplopia, or proptosis. Visual acuity was examined by Snellen’s chart, anterior segment by slit-lamp, intra-ocular pressure by non-contact tonometer, qualitative measurement of corneal sensation by a cotton-wisp and central corneal thickness was measured by pachymetry. Corneal endothelial cell parameters like endothelial cell density (ECD), coefficient of variation of cell area (CV), percentage of hexagonal cell (HEX) were measured by clinical specular microscope.

The age range was 14 to 82 years with mean age being 48.43±14.2 years. The male to female ratio was 1.34:1. Type-2 diabetes mellitus was the most frequently encountered endocrine disorder (64.7%), followed by hypothyroidism (13.3%). Addison’s disease was the least encountered (0.7%). The most severe changes to the cornea, such as chronic epithelial abnormalities, superficial punctate keratopathy, altered corneal sensations, and dry eyes, were observed in patients with type 2 diabetes, followed by Graves’s ophthalmopathy and hypothyroidism. Patients with T2DM and T1DM had elevated CCT values, reduced endothelial cell density, abnormally high coefficient of variance and low hexagonal cells.

The present study showed that different corneal alterations can be possible in endocrine disorders. So all endocrine disorders should undergo comprehensive ophthalmological examination to prevent visual impairment.
Role of hyperhomocysteinemia in the progression of diabetic retinopathy
Authors: Pooja H V  , Lakshmi M S
Published: March 2024

: The aim of this study was to determine the role of hyperhomocysteinemia in the progression of diabetic retinopathy and to determine the association of hyperhomocysteinemia with various grades of diabetic retinopathy.

Diabetic retinopathy is the most common ocular complication of Diabetes mellitus. Various studies have shown that mild elevations of homocysteine in plasma are associated with an increased risk of vaso-occlusive disease, thrombosis, and stroke.

: A total of 97 patients who were diagnosed with diabetic retinopathy from October 2018 to September 2019 were included in our study. Written informed consent was taken from all the participants. Best corrected visual acuity (BCVA), anterior segment examination using slit lamp biomicroscopy examination(SLE), fundoscopy using indirect ophthalmoscope and using 90D lens on slit lamp was done in all patients. Serum homocysteine was assessed in all. The data was analysed using SPSS version 17.0. Results were expressed as mean, frequency and percentage.

Out of 97 patients, mean serum homocysteine seen in mild non proliferative diabetic retinopathy, moderate non proliferative diabetic retinopathy, severe non proliferative diabetic retinopathy and proliferative diabetic retinopathy was 13.8 ± 0.33, 14.6 ± 0.44, 14.64 ± 0.41 and 15.78 ± 1.33 respectively.

: In our study we found serum homocysteine levels was elevated in proliferative diabetic retinopathy when compared to non-proliferative diabetic retinopathy.
Visual outcome and complications of phacoemulsification and manual small incision cataract extraction for age related cataract
Authors: Agrawal Garima , Patel Damini
Published: March 2024

The purpose of this study is to compare visual outcome and complications of manual small incision cataract surgery (MSICS) with posterior chamber IOL implantation (PC-IOL) and phacoemulsification with posterior chamber IOL implantation for age related cataract. The study compares the visual outcome and complications of MSICS and phacoemulsification with PC-IOL performed in 80 eyes at M & J Western Regional Institute of Ophthalmology (M&J WRIO) Ahmedabad, by assessing post operative Best corrected Visual acuity (BCVA), Surgically Induced astigmatism (SIA) and complications.

This was an Institutional based cohort interventional randomized, prospective study. MSICS and Phacoemulsification was performed on 80 eyes at M & J WRIO. The intraoperative complications were documented. The parameters that were examined on 1 postoperative day, 1 week, and 6 weeks postoperatively included uncorrected visual acuity, best corrected visual acuity (BCVA) at 6 weeks, intra ocular pressure by non -contact tonometry and keratometry at 6 weeks to rule out SIA.

Statistical analysis was performed using chi square test. p value <0.05 was taken as significant.

: MSICS & phacoemulsification had similar visual outcomes post-operatively. Phacoemulsification group produced less mean SIA (1.27 D) compared to MSICS group (1.29 D) and lesser (5%) complications than the MSICS group (10%). The comparison of all three parameters was not statistically significant between the two groups.

: Visual outcomes, SIA and complications were comparably the same in MSICS & phacoemulsification. Therefore, MSICS can be excellent alternative to phacoemulsification.
Vascular insufficiency leading to recurrent disc haemorrhage in normotensive glaucoma
Authors: Vishnupriya Narasannagari , Medikonda Malleswari , Mayuri Totli Kuruba
Published: March 2024

Disc haemorrhage is a sign of progression in normotensive glaucoma. We report a case who was presented with right eye (RE) optic disc haemorrhage and retinal nerve fibre layer defect at first visit, he was diagnosed as normotensive glaucoma (NTG). On subsequent follow up visits he had recurrent disc haemorrage and progression in visual fields and optical coherence tomography (OCT). On further evaluation he had h/o of dehydration episodes as he lives in hotter climates and on systemic evaluation he had carotid stenosis and nocturnal dip in 24 hr blood pressure monitoring. This case tells about importance of systemic evaluation in normotensive glaucoma.
MOGAD: A novel disease
Authors: Yasir Ziaul Haq , Singh Tushar Kant , Sharma Rakesh , Kumar Mukesh
Published: March 2024

Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an immune-mediated inflammatory neurological disease and a new addition to the demyelinating disorders of the central nervous system(CNS).In MOGAD, specific antibodies (MOG IgG) targeting MOG protein lead to primary demyelination in the CNS, but notably spare astrocytes. The most frequent presentation in children is ADEM and in adult ON. We present a case of 20 year old female who visited our OPD with complaints of diminution of vision with muscular weakness and strain while walking with a history of two similar episodes in the past. The clinical characteristics, laboratory investigation and neuroimaging help in diagnosis. Although the prognosis is generally favorable but severe residual disability can also occur.This underscores the importance of identifying the causes of demyelination on time and prompt treatment of this rather novel disease by judicious use of steroids based on standard protocolresulting in the general well-being of the patient. The present case therefore highlights the need to create awareness of the Clinical-Lab-Imaging characteristics of MOGAD andalso suggests the importance of making a detailed multidisciplinary approach into the cause of optic neuritis for better prognosis.
Experimental Digital Twins with Socio-Economic Artificial Environments of Forecast and Analytical Simulation Models
Authors: Evdokimov Dmitry
Published: March 2024

The technological development of Russia in recent years has been moving at an active pace due to external challenges that dictate the need to search for internal resources and poses serious challenges to the scientific community in terms of developing research potential and creating software and technological sovereignty, especially emphasizing the importance of the IT industry and long-term forecasting. Nanotechnology, which incorporates the concepts of IT, is a supra-industry technology, that is, it is the basis for achieving progress in any area of human activity. Without the use of information technology, it will be extremely difficult to achieve outstanding achievements in a dynamically changing world. There is an emerging interest in new computer modeling methods that make it possible to create experimental digital twins in the form of simulation models and can partially compensate for the incompleteness of information. Having modeled the necessary processes, it is possible to make management decisions on the construction of facilities, simulate socio-economic processes, and formulate a 10-year forecast about the demographic situation of the country.
The applied modeling tools discussed in the article demonstrate the usefulness of such management tools with developed functional elements in information and analytical management structures. Soon, this trend will increase and those countries that will take leading positions in this direction will be able to create ultra-effective forecasting and analytical scenarios with various levels of detail. By using all the functionality of simulation modeling, it is possible to create truly applied instrumental complexes with a potential basis for the implementation of such solutions in the structures of systems of distributed situational centers for the future development of technological sovereignty and the introduction of fundamentally new methods of strategic forecasting in the Russian Federation.
The effect of Islamic Social Reporting and Return On Asset on Firm Value with disclosure of Good Corporate Governance as a Moderating
Authors: Safitri Lia
Published: March 2024

Penelitian ini dilakukan dengan tujuan untuk mengetahui pengaruh pelaporan sosial islam dan Return on asset terhadap nilai perusahaan dengan tata kelola perusahaan yang baik sebagai variabel moderasi pada perusahaan yang terdaftar di jakarta islamic index (JII) periode 2018 – 2020. Jenis penelitian ini adalah kuantitatif dengan menggunakan data regresi panel dan Moderated Regression Analysis (MRA) sebagai analisis data. Data yang digunakan pada penelitian ini yaitu data sekunder yang bersumber dari laporan keuangan tahunan pada perusahaan yang tercatat di jakarta islamic index (JII)periode 2018 – 2020. Setelah memperoleh data dari Laporan Tahunan kemudian dianalisis menggunakan Software Eviews 12. Populasi pada penelitian ini yaitu seluruh perusahaan yang tercatat di jakarta islamic index (JII) periode 2018 – 2020. Untuk pengambilan sampel menggunakan metode purposive sampling dengan beberapa kriteria untuk mendapatkan sampel penelitian. Dan didapatkan 15 perusahaan untuk digunakan sebagai sampel penelitian. Hasil analisis data regresi menunjukkan bahwa pelaporan sosial islam dan tata kelola perusahaan yang baik tidak berpengaruh terhadap nilai perusahaan. Namun , aset berpengaruh terhadap nilai perusahaan. Dan hasil analisis Moderated Regression Analysis terhadap menunjukkan bahwa good corporate governance mampu memoderasi hubungan ISR terhadap nilai perusahaan kearah positif. Dan hubungan tata kelola perusahaan yang baik mampu memoderasi ROA terhadap nilai perusahaan kearah negatif. Kata kunci : Islamic Social Reporting (ISR), Return on assets (ROA), Nilai Perusahaan, Good Coporate Governance (GCG)
Analysis financial ratio on financial performance of banks with problem finance as intervening variables
Authors: Safitri Safitri , Nabila Rifda
Published: March 2024

The purpose of this study was to analyze the effect of CAR, BOPO and FDR on ROA with Non-performing Financing as an Intervening Variable in Islamic Commercial Banks for the 2016-2020 period. Where this research uses quantitative research using regression analysis as data analysis. This study uses secondary data in the form of panels using the annual data of each Islamic commercial bank selected as the research sample in the 2016-2020 period. The data obtained were then analyzed using the Eviews 10 application tool. The results of this study indicate that the CAR, BOPO, FDR and NPF variables have a partial effect on ROA. The CAR, FDR and NPF variables have no significant negative effect on ROA, while the BOPO variable has a significant negative effect on ROA. And the NPF variable cannot mediate the effect of CAR, BOPO and FDR on ROA. And the results of the research on the ROA of Islamic Commercial Banks before the pandemic (2019) and during the pandemic (2020) using the Wilcoxon Signed Rank Test showed that there were significant differences.
Manajemen laba bank syariah berdasarkan independensi dan efektivitas komite audit
Authors: Putri Disna Hilda Rosita , Maesaroh Dewi
Published: March 2024

This study aims to test the relationship between independence, expertise, frequency of meetings and audit committee time commitment to profit management. This research uses quantitative approach which uses 14 Sharia Commercial Bank Companies in Indonesia with Purposive Sampling data retrieval techniques and the remaining 9 companies. The data was analyzed using Multiple Regression Analysis. The results of this study show that partial independence, expertise, frequency of meetings and commitment of audit committee time have a significant effect on profit management. While simultaneously the independence, expertise, frequency of meetings and commitment of audit committee time have no significant influence on profit management.
THE EFFECT OF SOCIAL MEDIA MARKETING AND BRAND IMAGE ON LOYALTY WITH TRUST AS A MEDIATION VARIABLE
Authors: Yunissinta Punky , Fitriani Endah Nur
Published: March 2024

This study aims to examine the effect of social media marketing and brand image on loyalty with trust as a mediating variable. This research used quantitative research. This study used primary data by distributing questionnaires using google forms which were distributed at BRI Syariah KCP Magelang. The data were analyzed using SPSS tools. The population in this study were BRI Syariah KCP Magelang customers and 100 customers were used as the sample. The results of this study show that social media marketing, brand image, and trust affect loyalty. Trust can mediate social media marketing on loyalty and trust can mediate brand image on loyalty.
THE ANALYSIS OF MARKETING MIX STRATEGY ANALYSIS TO IMPROVE POTENTIAL CONSUMERS (CASE STUDY ON AMANDA BROWNIES CUSTOMERS IN SALATIGA)
Authors: Sundari Pipit , Tia Lestari Wahyuni
Published: March 2024

This study aims to determine the effect of the Marketing Mix variable on increasing Potential Consumers (Case Study of Amanda Brownies, Salatiga ). The variables used in this study consist of independent variables, namely Product (X1), Price (X2), Place (X3), Promotion (X4), and Physical Evidence (X5) variables and the dependent variable is Potential Consumer (Y). The sample of this study is 96 respondents. Data collection techniques use questionnaire. The research findings the product has a significant positive effect on increasing potential consumers, price had a significant positive effect on increasing potential consumers, place has a significant positive effect on increasing potential consumers, promotion has a positive and significant effect on increasing sales volume and physical evidence has a positive and significant
DIGITAL MARKETING FOR HALAL FOOD PRODUCT: THE EFFECT OF CUSTOMER REVIEW, HALAL CONTENT, AND USE OF E-PAYMENT
Authors: Arsiati Rira , Eri Puspita Rosana
Published: March 2024

This research examines the influence of customer reviews, halal content marketing, and the use of e-payment on consumer loyalty with purchasing decisions as an intervening variable at Mie Gacoan. The data used in this research is primary data, using a questionnaire. The questionnaire was distributed to 100 respondents, with the criteria being Muslim generation Z respondents (11-26 years old). The sampling technique used was KMO (Kaiser Mayer Olkin). The analysis techniques used in this research are validity test, reliability test, partial test (t test), simultaneous test (f test), coefficient of determination test, normality test, multicollinearity test, heteroscedasticity test, and Sobel test. The object of this research is Mie Gacoan. The results of this research show that the variables customer reviews, halal content marketing, and the use of e-payment have a positive and significant effect on purchasing decisions. Customer reviews, halal content marketing, and the use of e-payment have a positive and significant effect on consumer loyalty. In the Sobel test, the purchasing decision variable could mediate the influence of customer reviews, halal content marketing, and the use of e-payment on consumer loyalty.
ANALISIS PENGARUH WORD OF MOUTH, KUALITAS PRODUK, DAN ETIKA BISNIS ISLAM, TERHADAP KEPUTUSAN PEMBELIAN MELALUI KEPUASAN KONSUMEN SEBAGAI VARIABEL MODERATING
Authors: Hakim Sofyan , Rizky Rahmawati Aulia
Published: March 2024

The purpose of this study is to determine the influence of word of mouth variables, product quality, and Islamic business ethics on purchasing decisions with consumer satisfaction variables as moderating variables. A sample of 100 respondents used purposive sampling techniques. The data analysis technique used is SPSS 23. The results of word of mouth have no significant effect on purchasing decisions. Product quality has a significant and positive impact on purchasing decisions. Islamic business ethics have a positive and significant influence on purchasing decisions. and consumer satisfaction has a positive and significant influence on purchasing decisions. Meanwhile, in MRA testing, word of mouth variables, product quality, and Islamic business ethics have a positive and significant effect on purchasing decisions with customer satisfaction as a moderating variable. This means that customer satisfaction can strengthen the influence of word ofmouth variables, Islamic business ethics and product quality on purchasing decisions.
Global Islamic Banking Development: A Review and Bibliometric Analysis Using R-Biblioshiny Application
Authors: Fahamsyah Mohammad Hatta , Mawardi Imron , Laila Nisful , Shabbir Malik Shahzad
Published: March 2024

Islamic banking refers to a banking system that operates based on the principles of Islamic law and Sharia. The bank is guided by Islamic economics and follows specific guidelines and principles that differentiate it from the conventional banking system. The aim of this article is to provide insight into the extensive bibliometric literature on Islamic banking globally. The method used in this study is a bibliometric analysis of the literature collected in 2014 to 2023 from Scopus database,te sample of the study is 69 of the 317 publications. This research classifies and visualizes them using R-Biblioshiny software. Overall, this review provides an appropriate reference point for further research on 'Islamic Banking Globally'. The results of the bibliometric analysis reveal that the research focuses mainly on ”Islamic” and “Bank”. The findings of this research show that Islamic banking globally has experienced a significant trend in the last 9 years and to be of significant interest for discussion and research. Notably, the density visualization analysis, which involves measuring the co-occurrence network of keyword pairs reveals a compelling trend, thus indicating that this research theme is still interesting to research today. However, further research is needed in more detail considering the increasing development of Islam.
Global Economic Policy Uncertainty and Islamic Stock Market in Indonesia
Authors: Mashilal Mashilal , Amalia Farah , Visita Luksi
Published: March 2024

The investigation of economic policy uncertainty (EPU) was necessary during financial and trade integration between countries. In this context, there was a spillover effect of global economic policy protections impacting stock markets. Therefore, this research aimed to determine the effect of global policy proxied by the United States, China, and Japan on Islamic stock market in Indonesia. Macroeconomic indicators were also included in the research model and the time series data was obtained from January 2015 to December 2022. In addition, Vector Error Correction Model (VECM) was used as an analytical method in the model. The results showed that Islamic stocks responded positively to global economic policy, exchange rates, and exports to stock index, while inflation reported a negative response.
Mergers and Acquisitions in Islamic Banking In Indonesia: A Study on BSI and Bank Victoria Syariah
Authors: Ahmad Habibi Zaman Riawan
Published: March 2024

Mergers and acquisitions (MA) in Islamic banking in Indonesia can be viewed from the strategic interests of each bank. This research aims to examine the patterns of MA in Bank Syariah Indonesia (BSI) and Bank Victoria Syariah in Indonesia. It also discusses the positive and negative implications of the MA of these two banks, as seen in the developments before and after the MA. This research employs BOCR (Benefit, Opportunity, Cost, and Risk) analysis to assess the extent to which MA patterns occur in the merger outcomes at BSI. It also utilizes CAMEL (Capital Asset Earnings and Liquidity) analysis to evaluate the post-acquisition banking health at Bank Victoria Syariah. The research descriptively explains the MA conditions in these two Islamic banks in Indonesia and the impact of MA on the banks, employees, customers, and the general public. The study results indicate that themerger of three state-owned Islamic banking companies, namely Bank Syariah Mandiri, BRI Syariah, and BNI Syariah, into BSI was carried out not only to expand the market share of Islamic banking but also due to cost considerations. At the same time, the acquisition of Bank Victoria Syariah was made due to capital needs as required by the regulator.
A korai iskolaelhagyás vizsgálata interszekcionális megközelítésben
Authors: Bocsi Veronika , Varga Aranka , Fehérvári Anikó
Published: March 2024

Hungary ranks in the bottom third of the European Union regarding early school leaving, falling further and further away from the EU average year on year. The lower educational attainment and higher drop-out rates of Roma/Gypsy youth have been confirmed by several studies. Still, the descriptions are often two-dimensional, as in international approaches. The Hungarian Youth 2020 database allowed for a wider range of explanatory variables in the analysis. In our study, we examine the educational attainment of Roma youth aged 20-29 and then compare subsamples of Roma and non-Roma dropouts. Finally, we run a binary regression model on the database with early school leaving as the dependent variable and explanatory variables as background variables that may shape the odds of early school leaving. The social and economic backgrounds of Roma and non-Roma ESL learners differed, while parental education and subjective financial situation showed a less favourable pattern for Roma. The effect of Roma identity was significant in the regression model, but the explanatory power did not reach the effect of lower parental education. In other words, ethnic background is a crucial factor in dropout, while some segments of the family background are more significant.
Accelerated Idioventricular Rhythm in Acute Coronary Syndrome with ST Segment Elevation: Clinical Significance
Authors: ZOUZOU Hanane
Published: March 2024

Background: Accelerated Idioventricular rhythm in acute coronary syndrome with ST segment elevation is common after thrombolysis and it is relatively benign; its occurrence is considered as a sign of reperfusion of the occluded coronary artery.
Aims: The main objective of our study is the determination of the frequency of Accelerated Idioventricular rhythm in acute coronary syndrome with ST segment elevation after thrombolysis, the secondary objective is checking with coronary angiography if this rhythm really means the success of thrombolysis and reperfusion of the occluded coronary artery.
Methods and materials:  In this prospective study, conducted in the cardiology department of Hussein Dey hospital (Algiers-Algeria), 467 patients with acute coronary syndrome with elevated ST segment (87 women and 380 men) were enrolled between 28 February 2014 and 16 July 2015. The average age is 60 ± 13 years; at admission, a Holter recorder was attached in 448 patients, for continuous ECG monitoring during 48 hours, coronary angiography was performed in 329 patients.   
Kruskal’s ANNOVA or H tests were used for comparison of quantitative variables, χ2 test or Fisher’s exact test, were used for qualitative variables, all tests were performed with 1st species risk of 5%.
Results:  The frequency of Accelerated idioventricular rhythm recorded by the Holter ECG is 17.2 % (77 patients), CI 95%: [13.7%-20.7%], this frequency is 18.71 % (73 patients) CI 95%: [14.8 %-22.6%] in patients undergoing thrombolytic treatment.
There is no significant difference between the frequencies of persistence of chest pain in the groups of patients with or without accelerated idioventricular rhythm after thrombolysis: 5.47 % (4 patients) versus 5.99 % (19 patients) respectively, p = 0.979; also for the frequencies of persistence of ST segment elevation after thrombolysis: 4.10 % (3 patients) versus 6.94 % (22 patients) respectively, p = 0.476).   
The frequency of occluded coronary artery (TIMI 0) is low in group of patients with accelerated idioventricular rhythm 14.51 %, (9 patients) compared to group of patients without this rhythm 21.39 % (52 patients), but the difference isn’t significant (p= 0.227).
Conclusion: Accelerated idioventricular rhythm is common in acute coronary syndrome with elevated ST segment and generally considered as a sign of reperfusion; in our study, this rhythm may occur even in the absence of reperfusion of the occluded coronary artery and does not necessarily mean reperfusion or success of thrombolysis.
Making mass
Authors: Trivedi Nripesh
Published: March 2024

Making mass