bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figures S1 from DNA-Methylome–Based Tumor Hypoxia Classifier Identifies HPV-Negative Head and Neck Cancer Patients at Risk for Locoregional Recurrence after Primary Radiochemotherapy
Authors: Tawk Bouchra , Rein Katrin , Schwager Christian , Knoll Maximilian , Wirkner Ute , Hörner-Rieber Juliane , Liermann Jakob , Kurth Ina , Balermpas Panagiotis , Rödel Claus , Linge Annett , Löck Steffen , Lohaus Fabian , Tinhofer Ingeborg , Krause Mechtild , Stuschke Martin , Grosu Anca Ligia , Zips Daniel , Combs Stephanie E. , Belka Claus , Stenzinger Albrecht , Herold-Mende Christel , Baumann Michael , Schirmacher Peter , Debus Jürgen , Abdollahi Amir
Published: May 2023

Supplementary Figure 1. (Top) Venn Diagram showing the intersect between Hypoxia-M V2 significant DMPs (n=3397) and Hypoxia-M V1 significant DMPs (n=5129) 2551 (66%) of significant DMPs identified based on the 85th percentile of standard deviation are also included in the selection criteria of Hypoxia-M V1. (middle) Hypoxia-M V2 is prognostic in the TCGA HNSCC cohort (p=0.041) and the prognostic effect remained independent on multivariate analysis. (bottom) Multivariate Analysis revealed that patients predicted to have high Hypoxia by Hypoxia-M V2 had worsened OS outcomes (HR=1.59, p<0.026). Additionally, increasing age and pN2 nodal status were negatively prognostic of OS (p<0.05)
Data from TIL Therapy: Facts and Hopes
Authors: Monberg Tine J. , Borch Troels H. , Svane Inge M. , Donia Marco
Published: May 2023

Abstract
After a positive phase III trial, it is evident that treatment with tumor-infiltrating lymphocytes (TIL) is a safe, feasible, and effective treatment modality for patients with metastatic melanoma. Further, the treatment is safe and feasible in diverse solid tumors, regardless of the histologic type. Still, TIL treatment has not obtained the regulatory approvals to be implemented on a larger scale. Therefore, its availability is currently restricted to a few centers worldwide. In this review, we present the current knowledge of TIL therapy and discuss the practical, logistic, and economic challenges associated with implementing TIL therapy on a larger scale. Finally, we suggest strategies to facilitate the widespread implementation of TIL therapy and approaches to develop the next generation of TILs.
Data from Tumor-Agnostic Precision Medicine from the AACR GENIE Database: Clinical implications
Authors: Gouda Mohamed A. , Nelson Blessie Elizabeth. , Buschhorn Lars , Wahida Adam , Subbiah Vivek
Published: May 2023

Abstract
Biomarker-driven cancer therapy has revolutionized precision oncology. With a better understanding of tumor biology, tissue-agnostic targets have been characterized and explored which ultimately led to therapeutics with pan-cancer efficacy. To date, five molecular biomarkers have obtained FDA tissue-agnostic approval for targeted therapies and immunotherapies. Those include BRAF V600E mutations, RET fusions, NTRK fusions, high tumor mutation burden (TMB), and deficient mismatch repair (dMMR/MSI-High). Herein, we have used data from AACR project GENIE to explore the clinico-genomic landscape of these alterations. AACR GENIE is a publicly accessible registry of genomic data from multiple collaborating cancer centers. Current database (version 13.0) includes sequencing data of 168,423 samples collected from patients with different cancers. We were able to identify BRAF V600E, RET fusions, NTRK fusions, and high TMB in 2.9%, 1.6%, 1.5%, and 15.2% of pan-cancer samples; respectively. In this article, we describe the distribution of those tissue-agnostic targets among different cancer types. In addition, we summarize the current prospect on the biology of these alterations and evidence on approved drugs including pembrolizumab, dostarilmab, larotrectinib, entrectinib, selpercatinib, and dabrafenib/trametinib combination.
Data from Clinical Relevance of BRCA1 Promoter Methylation Testing in Patients with Ovarian Cancer
Authors: Blanc-Durand Félix , Tang Roseline , Pommier Margaux , Nashvi Marzieh , Cotteret Sophie , Genestie Catherine , Le Formal Audrey , Pautier Patricia , Michels Judith , Kfoury Maria , Hervé Robert , Mengue Sylvie , Wafo Estelle , Elies Antoine , Miailhe Gregoire , Uzan Jennifer , Rouleau Etienne , Leary Alexandra
Published: May 2023

AbstractPurpose:
Homologous recombination deficiency (HRD) is closely related to PARP inhibitor (PARPi) benefit in ovarian cancer. The capacity of BRCA1 promoter methylation to predict prognosis and HRD status remains unclear. We aimed to correlate BRCA1 promoter methylation levels in patients with high-grade ovarian cancer to HRD status and clinical behavior to assess its clinical relevance.
Experimental Design:
This is a retrospective monocentric analysis of patients centrally tested for genomic instability score (GIS) by MyChoice CDx (Myriad Genetics). The detection of BRCA1 promoter methylation and quantification of methylation levels were performed by quantitative droplet digital PCR methodology. High BRCA1 methylation was defined as ≥70% and deemed to be associated with homozygous silencing.
Results:
Of 100 patients, 11% harbored a deleterious BRCA1/2 mutation. GIS was considered positive (score ≥ 42) for 52 patients and negative for 48 patients. Using a 70% cutoff, 19% (15/79) of BRCA wild-type ovarian cancer had high BRCA1 methylation levels. All of the highly methylated tumors were classified as HRD, achieving a positive predictive value of 100%. We detected 14% (11/79) low-methylated tumors (1%–69%), and all of them were also classified as HRD. Mean GIS was 61.5 for BRCAmut, 66.4 for high-BRCAmeth, 58.9 for low-BRCAmeth, and 33.3 for BRCAwt unmethylated (P < 0.001). Low methylation levels detected in samples previously exposed to chemotherapy appeared to be associated with poor outcome post-platinum.
Conclusions:
Patients with ovarian cancer with high levels of BRCA1 hypermethylation are very likely to have high GIS and therefore represent good candidates for PARPi treatment. These results may be highly relevant to other tumor types for HRD prediction.
Data from DNA-Methylome–Based Tumor Hypoxia Classifier Identifies HPV-Negative Head and Neck Cancer Patients at Risk for Locoregional Recurrence after Primary Radiochemotherapy
Authors: Tawk Bouchra , Rein Katrin , Schwager Christian , Knoll Maximilian , Wirkner Ute , Hörner-Rieber Juliane , Liermann Jakob , Kurth Ina , Balermpas Panagiotis , Rödel Claus , Linge Annett , Löck Steffen , Lohaus Fabian , Tinhofer Ingeborg , Krause Mechtild , Stuschke Martin , Grosu Anca Ligia , Zips Daniel , Combs Stephanie E. , Belka Claus , Stenzinger Albrecht , Herold-Mende Christel , Baumann Michael , Schirmacher Peter , Debus Jürgen , Abdollahi Amir
Published: May 2023

AbstractPurpose:
Tumor hypoxia is a paradigmatic negative prognosticator of treatment resistance in head and neck squamous cell carcinoma (HNSCC). The lack of robust and reliable hypoxia classifiers limits the adaptation of stratified therapies. We hypothesized that the tumor DNA methylation landscape might indicate epigenetic reprogramming induced by chronic intratumoral hypoxia.
Experimental Design:
A DNA-methylome–based tumor hypoxia classifier (Hypoxia-M) was trained in the TCGA (The Cancer Genome Atlas)-HNSCC cohort based on matched assignments using gene expression–based signatures of hypoxia (Hypoxia-GES). Hypoxia-M was validated in a multicenter DKTK-ROG trial consisting of human papillomavirus (HPV)–negative patients with HNSCC treated with primary radiochemotherapy (RCHT).
Results:
Although hypoxia-GES failed to stratify patients in the DKTK-ROG, Hypoxia-M was independently prognostic for local recurrence (HR, 4.3; P = 0.001) and overall survival (HR, 2.34; P = 0.03) but not distant metastasis after RCHT in both cohorts. Hypoxia-M status was inversely associated with CD8 T-cell infiltration in both cohorts. Hypoxia-M was further prognostic in the TCGA-PanCancer cohort (HR, 1.83; P = 0.04), underscoring the breadth of this classifier for predicting tumor hypoxia status.
Conclusions:
Our findings highlight an unexplored avenue for DNA methylation–based classifiers as biomarkers of tumoral hypoxia for identifying high-risk features in patients with HNSCC tumors.
Supplementary Table 5 from The Immunopeptidome from a Genomic Perspective: Establishing the Noncanonical Landscape of MHC Class I–Associated Peptides
Authors: Bedran Georges , Gasser Hans-Christof , Weke Kenneth , Wang Tongjie , Bedran Dominika , Laird Alexander , Battail Christophe , Zanzotto Fabio Massimo , Pesquita Catia , Axelson Håkan , Rajan Ajitha , Harrison David J. , Palkowski Aleksander , Pawlik Maciej , Parys Maciej , O'Neill J. Robert , Brennan Paul M. , Symeonides Stefan N. , Goodlett David R. , Litchfield Kevin , Fahraeus Robin , Hupp Ted R. , Kote Sachin , Alfaro Javier A.
Published: May 2023

Mapping of ncMAPs to COSMIC frameshift mutations.
Supplementary Figures and Tables from Clonal Spreading of Tumor-Infiltrating T Cells Underlies the Robust Antitumor Immune Responses
Authors: Aoki Hiroyasu , Tsunoda Mikiya , Ogiwara Haru , Shimizu Haruka , Abe Haruka , Ogawa Tatsuro , Abe Takaya , Shichino Shigeyuki , Matsushima Kouji , Ueha Satoshi
Published: May 2023

Supplementary Figure S1-S5, Table S1-S12
KRT17 Promotes T-lymphocyte Infiltration Through the YTHDF2–CXCL10 Axis in Colorectal Cancer
Authors: Liang Wenfeng , Liu Huashan , Zeng Ziwei , Liang Zhenxing , Xie Hao , Li Wenxin , Xiong Li , Liu Zhihang , Chen Mian , Jie Haiqing , Zheng Xiaobin , Huang Liang , Kang Liang
Published: May 2023

Poor infiltration of T lymphocytes has been regarded as a crucial mechanism of tumor immune escape. Here, we demonstrate a protective role of KRT17 in colorectal cancer, where KRT17 reversed the tumor immunosuppressive microenvironment by increasing T-lymphocyte infiltration. High-throughput RNA sequencing suggested that KRT17 was significantly upregulated in deficient mismatch repair (dMMR) tumors compared with proficient mismatch repair (pMMR) tumors. In a colorectal cancer cohort of 446 cases, KRT17 expression positively correlated with better clinical outcomes. Krt17 overexpression decreased xenograft tumor growth in immune-competent mice. T-cell depletion in a murine model showed that the presence of T lymphocytes was necessary for Krt17-mediated disruption of tumorigenesis. Mass spectrometry and coimmunoprecipitation assays suggested KRT17 caused YTHDF2 degradation through the ubiquitin-proteasome system. Through high-throughput RNA immunoprecipitation sequencing, we found that CXCL10 was the target gene of the N6-methyladenosine (m6A) “reader” YTHDF2. KRT17 synergized with anti–PD-1 for better tumor control in an immunotherapy-resistant murine model. In a cohort of patients with colorectal cancer receiving pembrolizumab, high KRT17 expression was found within the tumors of responders. Collectively, we elucidated a critical role of KRT17 in colorectal cancer to prevent immune escape. These findings present new insights into potential therapeutic strategies and effective markers of immunotherapy reactivity against pMMR tumors.
TABLE 1 from Interethnic Differences in Bladder Cancer Incidence and the Association between Type 2 Diabetes and Bladder Cancer in the Multiethnic Cohort Study
Authors: Bogumil David , Cortessis Victoria K. , Wilkens Lynne R. , Le Marchand Loïc , Haiman Christopher A. , Maskarinec Gertraud , Setiawan Veronica Wendy
Published: May 2023

Cohort characteristics
Supplementary Table S2 from Interethnic Differences in Bladder Cancer Incidence and the Association between Type 2 Diabetes and Bladder Cancer in the Multiethnic Cohort Study
Authors: Bogumil David , Cortessis Victoria K. , Wilkens Lynne R. , Le Marchand Loïc , Haiman Christopher A. , Maskarinec Gertraud , Setiawan Veronica Wendy
Published: May 2023

Supplementary Table 2: Poisson model variable coefficients used to estimate absolute risk. Example rate, per 100,000 for 50 year old African Americans with diabetes: 21.6 = exp(-7.23 + 4.31*(log(50/70)) + 0.24*1) * 100,000
Supplementary Table S1 from Interethnic Differences in Bladder Cancer Incidence and the Association between Type 2 Diabetes and Bladder Cancer in the Multiethnic Cohort Study
Authors: Bogumil David , Cortessis Victoria K. , Wilkens Lynne R. , Le Marchand Loïc , Haiman Christopher A. , Maskarinec Gertraud , Setiawan Veronica Wendy
Published: May 2023

Supplementary Table 1: Global proportional hazards test for exposure and covariates included in the model
Supplementary Figure S5 from Interethnic Differences in Bladder Cancer Incidence and the Association between Type 2 Diabetes and Bladder Cancer in the Multiethnic Cohort Study
Authors: Bogumil David , Cortessis Victoria K. , Wilkens Lynne R. , Le Marchand Loïc , Haiman Christopher A. , Maskarinec Gertraud , Setiawan Veronica Wendy
Published: May 2023

Supplementary Figure 5: Race/ethnicity specific associations between Any T2D and BCA, with censorship of BCA cases that occurred within 2 years of incident T2D as non-cases. Models adjusted for pack-years smoked (0, 1-10, 11-20, 21-30, 31-40, >40), alcohol consumption (<1 drinks/month, ≤1 drinks/day, >1 drinks/day), sex (male, female), number of cigarettes smoked per day among smokers (5 cigarettes or less, 6-10 cigarettes, 11-20, 21-30, 31 or more), race/ethnicity (European American, African American, Japanese American, Latin American, Native Hawaiian), and reproductive factors among females. Body mass index (BMI, kg/m3) and smoking status (ever, never, current) were included as strata variables due to their proportional hazard violation. Categorical birthyear was also included as a strata variable to adjust for possible cohort effects. CI: Confidence Interval; HR: Hazard Ratio; P het: P- heterogeneity for likelihood ratio test for difference in association across race/ethnicity groups.
Supplementary Figure S11 from Interethnic Differences in Bladder Cancer Incidence and the Association between Type 2 Diabetes and Bladder Cancer in the Multiethnic Cohort Study
Authors: Bogumil David , Cortessis Victoria K. , Wilkens Lynne R. , Le Marchand Loïc , Haiman Christopher A. , Maskarinec Gertraud , Setiawan Veronica Wendy
Published: May 2023

Supplementary Figure 11: Associations between Any T2D and BCA by race/ethnicity among never smokers. Models adjusted for alcohol consumption (<1 drinks/month, ≤1 drinks/day, >1 drinks/day), sex (male, female), race/ethnicity (European American, African American, Japanese American, Latin American, Native Hawaiian), and reproductive factors among females. Body mass index (BMI, kg/m3) was included as a strata variable due to a proportional hazard violation. Categorical birthyear was also included as a strata variable to adjust for possible cohort effects. CI: Confidence Interval; HR: Hazard Ratio; P het: P- heterogeneity for likelihood ratio test
for difference in association across covariate levels.
FIGURE 3 from Interethnic Differences in Bladder Cancer Incidence and the Association between Type 2 Diabetes and Bladder Cancer in the Multiethnic Cohort Study
Authors: Bogumil David , Cortessis Victoria K. , Wilkens Lynne R. , Le Marchand Loïc , Haiman Christopher A. , Maskarinec Gertraud , Setiawan Veronica Wendy
Published: May 2023

A, Incidence of bladder cancer by Any T2D exposure status, per 100,000 py. Each line represents age-specific incidence, with the solid line indicating incidence among those without Any T2D and the dotted line indicating incidence among those with Any T2D. Incidence was estimated using Poisson regression model estimates within groups (Supplementary Table S2). Data were tabulated and fit using race/ethnicity, exposure status, and 5-year age categories. B, Cumulative risk percent of bladder cancer based on age obtained by race/ethnicity and Any T2D status, with the solid line indicating incidence among those without Any T2D and the dotted line indicating incidence among those with Any T2D. Age at which 1% lifetime risk is marked by the horizontal line and indicated age.
A lógica do sensível: a operação do pensamento selvagem em Lévi-Strauss
Authors: Vega Maria Isabel
Published: May 2023

Este trabalho apresenta a lógica do sensível e demonstra como opera o pensamento selvagem de acordo com Lévi-Strauss. Para isso, o texto revisa capítulos de duas obras do antropólogo ─ Totemismo hoje e O pensamento selvagem ─, abordando sobretudo o conceito de pensamento selvagem, um método de operar o pensamento através daquilo que é sensível, se caracterizando como uma “ciência do concreto”, além de discutir o totemismo, fenômeno utilizado pelos povos primitivos por propor uma operação lógica que os permite compreender o universo à sua volta.
Processo democrático na Venezuela e as tentativas de violação de sua soberania
Authors: Santanna Marcos Jesus de
Published: May 2023

As décadas entre 1960 e 1970 se caracterizaram por grande crescimento do Produto Interno Bruto (PIB), mas nos anos 1980 e 1990 a crise dos países latinos e a oscilação do preço do barril de petróleo culminou em desemprego, inflação e aumento da desigualdade social. A eleição de Hugo Chávez ocorreu em 1998 após um período de grande revolta popular que questionava as ações neoliberais dos governos anteriores que acentuavam a desigualdade social. O alinhamento da Colômbia com os Estados Unidos criou uma estratégia de ocupação do território colombiano pelo exército estadunidense num plano para proteger a região andina do avanço da esquerda. O Plano Colômbia se deu para ameaçar a soberania do estado venezuelano, articulando tentativas de golpes de estado e produzindo artimanhas para desestabilizar os governos de Hugo Chávez e Nicolás Maduro.
Operação chacina: rotulações da chacina de Jacarezinho em jornais selecionados
Authors: Silva Beatriz Araújo da , Fracaro Marcos Garcia
Published: May 2023

Este trabalho resulta da coleta de materiais jornalísticos acerca da chacina policial ocorrida na favela do Jacarezinho em 6 de maio de 2021, buscando analisá-los qualitativamente à luz do interacionismo simbólico e do labelling approach. Sendo este um dos casos mais violentos da história do Rio de Janeiro e que tomou as manchetes em todo país nos principais jornais e demais meios de comunicação, buscamos desnudar os discursos e categorizações que se deram no entorno do fato ocorrido e dos agentes sociais. A partir deste estudo, revelam-se as disputas de narrativas e rotulações em torno da qualificação dos envolvidos e das definições da situação, o que permite então esmiuçar as construções simbólicas em torno de atores e grupos sociais tidos como desviantes por diferentes mídias informativas, bem como sua comparação.
Funes, o Memorioso: as distorções da memória e a importância do esquecimento
Authors: Delela Giovanna Rocha
Published: May 2023

Este artigo analisa o conto Funes, o Memorioso, publicado em 1944 por Jorge Luis Borges (1899-1986), e enfoca a temática da memória e do esquecimento. Nosso objetivo é analisar a memória do personagem Irineu Funes, questionando sua adequação às características básicas da memória humana. Primeiramente, retoma-se as interpretações e reflexões antes feitas sobre o conto, no que tange à temática da memória. Em seguida, será feita uma reflexão sobre as características da memória humana e o importante papel cumprido pelas suas distorções e pelo esquecimento. Por fim, será feita uma equiparação entre a memória humana e a memória de Irineu Funes, concluindo-se que são essencialmente distintas, e que a memória de Funes mais se assemelha a um meio de registro: armazena tudo sem seleção. Uma vez que Funes é privado daquilo que o constitui como ser humano, o resultado é a sua desumanização.
Masculinidades e o homem latino-americano: transformações, perpetuações e novos estereótipos em Legally Blonde (2001)
Authors: Silva Gustavo Santos da
Published: May 2023

Mediante a necessidade e a ebulição dos estudos sobre as masculinidades, o desenvolvimento deste artigo visa apresentar os resultados parciais obtidos após a análise do filme Legally Blonde (Legalmente Loira), dirigido por Robert Luketic (2001), frutos de pesquisa de monografia ainda a ser publicada. Por meio de personagens como Enrique (Greg Serano), David (Oz Perkins) e Warner Huntington (Matthew Davis), este artigo ambiciona refletir acerca da produção das masculinidades, em especial da masculinidade latino-americana, mediante o cinema hollywoodiano, atentando-se para novos espaços, novas limitações, para as perpetuações de estereótipos previamente desenvolvidos pela indústria cinematográfica hollywoodiana e, também, para os encontros e diálogos (amigáveis ou não) entre América Latina e Estados Unidos da América.
A sociabilidade virtual da comunidade brasileira de Destiny 2 na pandemia de COVID-19
Authors: Taranto Raphael de
Published: May 2023

A partir de uma etnografia da comunidade brasileira do jogo multiplataforma Destiny 2, estudou-se a sociabilidade virtual de seus jogadores durante a pandemia de COVID-19 no Brasil e se ele contribuiu para que o jogador lidar com questões derivadas do período. Após compreender a identidade virtual do gamer e como se dá a interação entre a comunidade brasileira do jogo, verificou-se também uma espécie de solidariedade comunitária e mortuária por jogadores falecidos durante o momento pandêmico. Por fim, cruzouse os dados da pesquisa realizada com teorias principalmente de Erving Goffman e Pierre Lévy, para investigar se há relação entre o que foi observado na pesquisa realizada e nos conceitos de ator-espectador do primeiro autor e de virtual do segundo.
Um passeio por Novi Beograd: utopia, globalização e decadência
Authors: Loureiro Mariana Hebling Alen
Published: May 2023

Nova Belgrado [original: Novi Beograd/Нови Београд] é um município da cidade de Belgrado construído na planície delimitada pelos rios Sava e Danúbio. Esse espaço, que durante séculos funcionou como uma área fronteiriça entre os impérios Otomano e Austro-húngaro, permaneceu inabitado até o meio do século XX: foi apenas depois da Segunda Guerra Mundial que a região passou a ser ressignificada para os habitantes da República Federativa Socialista Iugoslávia, por meio das iniciativas de edificação de uma nova capital para o seu país em (re)construção. O projeto, elaborado arquitetos iugoslavos, buscava se distanciar das cidades históricas adjacentes, em um gesto de afastamento da velha Belgrado que, para além do seu estado de ruína pósguerra, também estava fortemente associada à monarquia sérvia do Reino da Iugoslávia (1918 – 1943). Assim, a construção desse novo centro administrativo representa simultaneamente a proclamação de uma nova época para o país e a materialização da ruptura com a União Soviética (1948), em uma tentativa de redirecionar para si o imaginário social em torno de Moscou como a capital socialista e se afastar do estilo arquitetônico predominante no Bloco do Leste. Após o violento colapso iugoslavo, as construções que ocupam as ruas de Nova Belgrado adquiriram um caráter diferente do seu propósito inicial: entre privatizações e abandono, complexos industriais inteiros se encontram em estado de decadência, enquanto empresas estrangeiras ocupam os edifícios antes destinados aos órgãos administrativo-estatais, marcando mais uma etapa na transformação dessa região. As fotografias dessa série, feitas em 2020, revelam a ambiguidade da Nova Belgrado atual, na qual a ampla presença de capital estrangeiro coexiste com as ruínas industriais das empresas estatais. Assim, as construções monumentais, que testemunham um estilo arquitetônico possível graças às confluências culturais do não-alinhamento iugoslavo, guardam a memória de uma outra forma de multiculturalismo, substituída pela lógica da globalização neoliberal.
Antropologia, educação e rituais: um diálogo (Resenha do artigo: “Choise and access to the best schools of Rio de Janeiro: A rite of passagem”, de Rodrigo Rosistolato)
Authors: Pereira Rosilaine
Published: May 2023

“Escolha e acesso às melhores escolas do Rio de Janeiro: Um rito de passagem”, de Rosistolato (2015), se propõe a pensar fenômenos educacionais a partir da teoria antropológica clássica dos rituais. Para isso, o autor investiga os eventos de “remanejamento” e “realocação” entre o primeiro e segundo ciclo do ensino fundamental, em escolas públicas das Zonas Norte e Sul da cidade do Rio de Janeiro, como um ritual de passagem que envolve não apenas questões de burocracia escolar, que automaticamente executaria essas práticas com esses estudantes, mas, também, critérios que vão além do que está explícito dentro do mecanismo escolar. Além disso, Rosistolato cria a categoria de “rituais de boa escola”, que seriam rituais em que as famílias das crianças praticam ações que envolvem funcionários do estado a fim de fazer com que seus filhos sejam “realocados” e “remanejados” para as melhores escolas da cidade. Os achados desta pesquisa demonstram que há estigmatização de estudante, pois estudantes considerados “bons” são transferidos para escolas, também, “boas”, e os estudantes com baixo desempenho vão para escolas com baixo prestígio.
Sobre as experiências que possibilitaram a descoberta da vontade, segundo Hannah Arendt
Authors: Pereira Lucas André Marques
Published: May 2023

Na obra A Vida do Espírito, Hannah Arendt define a vontade como uma faculdade autônoma do espírito humano. A fim de justificar tal definição, a autora realiza um estudo histórico para desvelar quais experiências da humanidade tornaram possível a descoberta da vontade. Neste trabalho, nosso objetivo é reconstruir o conceito de vontade, segundo Arendt, e compreender quais foram essas experiências e como elas possibilitaram a descoberta da vontade enquanto uma faculdade autônoma do espírito.
Passeio aquarelado pelo Centro Histórico de Santos
Authors: Verde Letícia Passarelli
Published: May 2023

A região mais antiga da cidade de Santos é retratada através de um passeio aquarelado que possibilita experimentar cenas do cotidiano do Centro Histórico de Santos, que por muitas vezes passam despercebidas. Desta forma, frações de momentos visuais por mais simples e comuns que pareçam são evidenciados, recebendo uma visão mais sensível e curiosa para com esses patrimônios e a região. A técnica utilizada é aquarela sobre papel. Os locais retratados, respectivamente são: Casa da Frontaria Azulejada, Pátio Interno da Casa da Frontaria Azulejada, Antiga Estação Railway SantosJundiaí, Convento do Carmo com vista da Rua Itororó, Catedral de Santos Nossa Senhora do Rosário, Igreja Nossa Senhora do Rosário, Monumento ao Trabalhador Portuário, e Ruínas dos antigos armazéns do Porto de Santos. As imagens fizeram parte do projeto “Postais Culturais”, com fomento contemplado via edital de “Produção de Exposições Inéditas de Artes Visuais” do Programa de Ação Cultural do Governo do Estado de São Paulo (ProAC 10/2019). O projeto contou com a exposição de 33 obras, visita guiada, rodas de conversa e oficinas de aquarela.
O Ideólogo nas nuvens: a ideia fixa e os problemas da formação em O adolescente
Authors: Almeida Rodrigo Mortara
Published: May 2023

Neste artigo nos debruçaremos sobre a ideia de Arkadi, protagonista do romance de Dostoievski O adolescente (1875), de tornar-se um Rothschild. A partir de uma análise dos protótipos e de alguns aspectos da função artística desta ideia, fundamentada principalmente nas formulações expostas por Bakhtin em seu Problemas da poética de Dostoievski, tentaremos apontar para alguns limites da leitura da obra como romance de formação (Bildungsroman), que aparecem quando consideramos detidamente alguns aspectos da poética do autor presentes na representação artística das ideias e certas particularidades da situação russa na década de 1870 incompatíveis com a ideia de formação, ao menos quando tomada em seu sentido clássico.
Heterogeneity of Repolarization and Cell-Cell Variability of Cardiomyocyte Remodeling Within the Myocardial Infarction Border Zone Contribute to Arrhythmia Susceptibility
Authors: Amoni Matthew , Vermoortele Dylan , Ekhteraei-Tousi Samaneh , Doñate Puertas Rosa , Gilbert Guillaume , Youness Mohamad , Thienpont Bernard , Willems Rik , Roderick H. Llewelyn , Claus Piet , Sipido Karin R.
Published: May 2023

Background:

After myocardial infarction, the infarct border zone (BZ) is the dominant source of life-threatening arrhythmias, where fibrosis and abnormal repolarization create a substrate for reentry. We examined whether repolarization abnormalities are heterogeneous within the BZ in vivo and could be related to heterogeneous cardiomyocyte remodeling.

Methods:

Myocardial infarction was induced in domestic pigs by 120-minute ischemia followed by reperfusion. After 1 month, remodeling was assessed by magnetic resonance imaging, and electroanatomical mapping was performed to determine the spatial distribution of activation-recovery intervals. Cardiomyocytes were isolated and tissue samples collected from the BZ and remote regions. Optical recording allowed assessment of action potential duration (di-8-ANEPPS, stimulation at 1 Hz, 37 °C) of large cardiomyocyte populations while gene expression in cardiomyocytes was determined by single nuclear RNA sequencing.

Results:

In vivo, activation-recovery intervals in the BZ tended to be longer than in remote with increased spatial heterogeneity evidenced by a greater local SD (3.5±1.3 ms versus remote: 2.0±0.5 ms,
P
=0.036, n
pigs
=5). Increased activation-recovery interval heterogeneity correlated with enhanced arrhythmia susceptibility. Cellular population studies (n
cells
=635–862 cells per region) demonstrated greater heterogeneity of action potential duration in the BZ (SD, 105.9±17.0 ms versus remote: 73.9±8.6 ms;
P
=0.001; n
pigs
=6), which correlated with heterogeneity of activation-recovery interval in vivo. Cell-cell gene expression heterogeneity in the BZ was evidenced by increased Euclidean distances between nuclei of the BZ (12.1 [9.2–15.0] versus 10.6 [7.5–11.6] in remote;
P
<0.0001). Differentially expressed genes characterizing BZ cardiomyocyte remodeling included hypertrophy-related and ion channel–related genes with high cell-cell variability of expression. These gene expression changes were driven by stress-responsive TFs (transcription factors). In addition, heterogeneity of left ventricular wall thickness was greater in the BZ than in remote.

Conclusions:

Heterogeneous cardiomyocyte remodeling in the BZ is driven by uniquely altered gene expression, related to heterogeneity in the local microenvironment, and translates to heterogeneous repolarization and arrhythmia vulnerability in vivo.
Women and Peace Negotiations: Looking Forward, Looking Back
Authors: Anderson Miriam J. , Golan Galia
Published: May 2023

Despite the global norm favoring women’s participation in peace negotiations, women continue to face constraints in accessing, influencing, and benefitting from peace settlements. This special issue of International Negotiation lays the groundwork for a future research agenda, calling for attention to gender-based analysis; mixed-method research designs, comparative case studies, and attention to “negative” cases; more examination of the relationship between gender-inclusivity at peace talks and the subsequent conditions for women; and policy recommendations for international actors. This introduction to the issue provides a review of the literature on women and peace negotiations, offers an overview of the issue’s six articles, and proposes a future research agenda.
On Calliandra and Afrocalliandra (Fabaceae-Caesalpinioideae)
Authors: THULIN MATS
Published: May 2023

The history of the genus Calliandra is reviewed, with particular reference to the two African species C. gilbertii and C. redacta. These species have been segregated as Afrocalliandra, based on proposed differences from a neotropical Calliandra. The stated differences are acalymmate, 7-celled (versus calymmate, 8-celled) polyads, presence (versus absence) of extrafloral nectaries, and presence (versus absence) of spines or thorns. A scrutiny of these claims shows that neither number of cells in the polyads, nor extrafloral nectaries, nor armature can be used to separate the two African species from the rest of the genus. The only remaining difference is the acalymmate polyads, a plesiomorphic state among mimosoids. On the contrary, a circumscription of Calliandra that includes also the two African species is, apart from being robustly supported by molecular data, also very strongly supported morphologically by 8-celled asymmetrical polyads with tail cells provided with viscin bodies (which are unique among legumes), by expanded stigmas with a wide area of polyad receptivity (which are unique among mimosoids), and by sagittate, petiolate and persistent cotyledons. A return to a circumscription of Calliandra that includes also the two African species is therefore proposed. Calliandra is subdivided into subg. Calliandra, with ca. 140 species in the Neotropics, and subg. Afrocalliandra, comb. et stat. nov., with C. gilbertii in Somalia and Kenya, and C. redacta in South Africa.
Phylogenetic studies of the subgenus Petrophilus Chaudoir (Coleoptera: Carabidae: Pterostichus), with description of a new species sympatric with P. thunbergi Morawitz
Authors: SASAKAWA KÔJI , KUBOTA KÔHEI
Published: May 2023

Based on the structures of the male genitalia, the subgenus Petrophilus Chaudoir is redefined, and five subgenera, viz., Euryperis Motschulsky, Morphnosoma Lutshnik, Euferonia Casey, Feroperis Lafer, and Moritapterus Berlov, are synonymized with Petrophilus. Phylogenetic analyses based on eighteen morphological characters revealed that the subgenus Petrophilus is monophyletic, whereas most traditional subgenera synonymized with Petrophilus are non-monophyletic. Pterostichus (Petrophilus) tuberifer Sasakawa, sp. nov., a sympatric species with P. thunbergi Morawitz, is described from Japan.
The Apanteles adelinamoralesae species group (Hymenoptera, Braconidae) from Brazil, with descriptions of three new species reared from fruit borers(Lepidoptera, Depressariidae)
Authors: SHIMBORI EDUARDO MITIO , GIACOMELLI ARTHURO DE CASTRO STOLF , FERNÁNDEZ-TRIANA JOSÉ L. , WATANABE ISABELA MIDORI , SANTOS ELIABER BARROS , SANTOS JAKELINE MARIA DOS , FAZOLIN WILIAN XAVIER , PENTEADO-DIAS ANGÉLICA MARIA
Published: May 2023

With more than 633 species, Apanteles is the largest genus within the subfamily Microgastrinae (Hymenoptera, Braconidae). We describe three new species reared from pests of commercial fruits, Apanteles ahuacatl Shimbori, Giacomelli & Fernández-Triana sp. n., A. aratiku Shimbori sp. n., and A. mayochinchipe Shimbori sp. n. They parasitize caterpillars in the subfamily Stenomatinae (Depressariidae): the soursop moth Cerconota anonella (Sepp), in fruits of sweetsop (Annona squamosa L.) and atemoya (Annona squamosa x Annona cherimola Mill.) (Annonaceae), the avocado borer Stenoma catenifer Walsingham, in fruits of avocado (Persea americana Mill.) (Lauraceae), and the cacao shoot borer Stenoma decora Zeller, in fruits and shoots of cacao (Theobroma cacao L.) (Malvaceae). The new Apanteles species are included in an expanded version of the key provided by Fernández-Triana et al. (2014) for the Apanteles adelinamoralesae species group. In addition, the previous record of Apanteles stenomae Muesebeck in Brazil is revised and considered to actually represent the species A. yolandarojasae Fernández-Triana.
Conflict narrative, stigmatisation and strategic behaviour of religious scientists in the Argentinean scientific field
Authors: Fitz Herbert Arturo L. , Rivera Reynaldo , Ketelhohn Frank , Elsdon-Baker Fern
Published: May 2023

Recent surveys show that most scientists do not perceive a conflict between science and religion. However, in many Western societies the “conflict narrative” prevails, which states that science grows at the expense of religion, and vice versa. Furthermore, evidence indicates the presence of stigmas against religion in many scientific fields of the West. Why do religious scientists feel discriminated in a field where several of their colleagues are not prejudiced against religion? Based on 22 in-depth interviews and 2 focus groups with Argentinean scientists, we show that the conflict narrative and the stigmatisation of religious scientists are present in the Argentinean scientific field. We argue that the conflict narrative is learned as part of the shared understandings of the field during the socialisation of Argentinian scientists in public institutions, where the secular norm prevails. Religious scientists adapt by strategically hiding their beliefs from their colleagues. This behaviour means that the narrative is not challenged in public, thus generating a feedback loop where the notion that there is a broad consensus about religion in the field reinforces the incentives for the strategic interaction of religious scientists.
Pedagogical reflections on New Testament Apocrypha: More Noncanonical Scriptures, volume 2
Authors: Hannan Sean
Published: May 2023

In this review article, the author makes the case for Tony Burke’s recent second volume of New Testament Apocrypha: More Noncanonical Scriptures (Eerdmans, 2020) as a publication that can help historians and scholars of religion navigate the convoluted warrens of ancient Christian literature. Adopting a pedagogical lens, the author argues that this volume goes deeper than standard tomes like Marvin Meyer’s Nag Hammadi Scriptures (HarperOne, 2007), offering its audience a more rigorously up-to-date picture of the state of Apocrypha research. The level of rigour and detail on display here might also make the volume more suitable for graduate or upper-level undergraduate courses. In order to support his presentation of the pedagogical value of Burke’s work, the author draws on specific examples rooted in several primary sources contained therein, from the Old Uyghur Adoration of the Magi to the Byzantine Life of Mary Magdalene.
Task-Relevant Smartphone Messages Within Work Zones: A Driving Simulation Study
Authors: Craig Curtis M. , Tian Disi , Morris Nichole L.
Published: May 2023

Objective

This study explored the impact of in-vehicle messages relative to roadside messages to alert drivers to events within a simulated work zone, in order to determine if these messages can improve driving performance within the work zone.

Background

Safety risks in work zones are usually mitigated by design standards and clear signage to communicate work zone information to drivers. Due to distraction and other driving task demands, these signs are not always noticed by motorists, nor are they always followed when they are noticed.

Method

The driving simulation tested drivers in two different types of work zones, shoulder work, and lane closure. Participants drove through these work zones three times, each with different messaging interfaces to communicate hazardous events to the driver. The interfaces included a roadside, portable changeable message sign, a smartphone presenting only auditory messages, and a smartphone presenting audio-visual messages.

Results

There was significantly better driving performance on key metrics including lane deviation for the in-vehicle message conditions relative to the roadside signs. Furthermore, drivers directed visual attention toward the roadway for the in-vehicle message conditions relative to the roadside sign condition.

Conclusion

The results indicate that in-vehicle messaging could provide benefits to primary task performance in driving if the message content is appropriately designed.

Application

The findings provide support for a design framework to support in-vehicle communication to drivers approaching work zones and other environments to safely alert them to hazards.
Psychological/Personal recovery and its correlates in patients with first episode psychosis
Authors: Laxmi Raj , Sahoo Swapnajeet , Grover Sandeep , Nehra Ritu
Published: May 2023

Background:

Recovery in psychosis is a multidimensional construct. The numbers of studies specially focusing on the recovery aspects in patients with first episode psychosis (FEP) are limited, with no study from India. Further, no study has looked specifically into the variables that affect recovery process in patients with FEP and little is known about factors which influence recovery in patients with FEP.

Aim:

To evaluate psychological recovery and its correlates in patients with FEP, currently in clinical remission.

Methodology:

One hundred three patients of FEP in clinical remission were assessed on Recovery Assessment Scale (RAS), Positive and Negative Syndrome Scale for Schizophrenia, Calgary Depression Rating Scale for Schizophrenia, Negative Symptom Assessment 16, Rosenberg Self-esteem Scale, Social and Occupational Functioning Assessment Scale, the Alcohol, Smoking and Substance Involvement Screening Test, Beck Cognitive Insight Scale, Internalized Stigma of Mental Illness Scale, the Everyday discrimination Scale, Subjective Scale to Investigate Cognition in Schizophrenia and social cognitive deficits in theory of mind was evaluated on the Social Cognition Rating Tools in Indian Setting-Theory of Mind. The needs of the participants were assessed on the Camberwell Assessment of Needs – Research version and Supplemental Assessment of Needs. Coping, social support, medication adherence were also assessed by standardized scales.

Results:

The mean weighted score was highest for goal and success orientation subscale followed by seeking and relying on social support, personal confidence and hope, overcome the illness and awareness and control over the illness as assessed by 41 items of the RAS. The main factors identified to affect psychological recovery in patients with FEP were duration of untreated psychosis, greater psychopathology, lower self-esteem, total unmet need, feeling of discrimination and stigmatization.

Conclusion:

The present study suggests that treatment of FEP should be started at the earliest and issues such as residual psychopathology, lower self-esteem, total unmet need, feeling of discrimination and stigma during the remission phase should be addressed by psychosocial interventions to promote psychological recovery in patients with first episode psychosis.
The Sociocognitive Origins of Personal Mastery
Authors: Brett Gordon , Dubash Soli
Published: May 2023

This article examines the relationship between cognitive processing and mastery. While scholars have called for the integration of sociological and cognitive analyses of mastery, sociological research has focused almost exclusively on mapping its social correlates. As a result, sociologists have relied on untested and underspecified assumptions about cognition to explain the efficacy of mastery. Taking an interdisciplinary approach integrating research on mastery, dual-process models of cognition, and intersectionality, we specify and test the hypothesis that deliberate thinking dispositions are associated with a greater sense of control over one’s life chances and assess whether this relationship varies across different intersections of social positions. Regression results from survey data in a diverse student sample (N = 982) suggest a positive correlation between deliberate cognitive style and personal mastery. However, results from a quantitative intersectional analysis demonstrate that this relationship does not hold for East Asian women.
Does Taping Have an Immediate Effect on Shooting the Target?
Authors: Kisa Eylul Pinar , Kaya Begum Kara
Published: May 2023

In overhead shooting athletes may have increased activity of the upper trapezius and inhibition of other shoulder muscles active during upper extremity elevation. In this study, we aimed to increase target retention and shoulder proprioception sense accuracy by taping in a way that would activate the lower trapezius muscle in elite adolescent archers. Our participants were 43 elite young athletes, aged 11–14 years, from the Archers Foundation Sports Club. We gathered athletes' sociodemographic information (age, height, weight, gender, the time they were engaged in archery, and other sports they were involved in), and we assessed their posture via the New York Posture Scale (NYPS) before taping. We evaluated them for the presence of scapular asymmetry using the Lateral Scapular Slide Test (LSST) and assessed their proprioception with the active displacement test and their target-reaching performances with the Archery Shooting Score (ASS). Since testing and scoring with the ASS is different for 11–12 and 13–14 age groups, we divided this sample into two different age groups for all analyses. There were significant changes in ASS and proprioception in both age groups, with medium to large effect sizes. There were between intragroup pre- and post-taping changes in classification according to the presence of scapular asymmetry, and there were significant changes in the archery shooting score and proprioception in both groups, with medium to large effect sizes ( p < 0.05). Thus, taping applied to the lower part of the trapezius had a large to medium effect on proprioception and shooting accuracy improvement in these young archers.
Music education undergraduates’ construction of music teacher role-identity
Authors: Long Chengcheng
Published: May 2023

The purpose of this study was to explore Chinese music education undergraduates’ music teacher role-identities. Data were collected through focus groups and individual interviews. A qualitative content analysis, using McCall and Simmons theory of role-identity as the theoretical framework, revealed that each of the 25 students’ imaginative view of self as a music teacher was an ongoing process of negotiation during their undergraduate education. Students were consistently negotiating the content of their own music teacher role-identities through balancing their needs for rewards from others and their own self-support. Students described the conventional character of a teacher as being respectful, responsible, and fair and the role of a teacher as acting professionally in music and teaching through cognitive role-taking and improvisation, as well as expressive enactment and negotiations. Students were active agents in constructing their role-identities, bringing their own idiosyncratic interpretations to music teacher positions. McCall and Simmons’ prominence and salience hierarchies helped understand how students valued their music teacher role-identity, compared to their other role-identities. Implications and suggestions for music teacher education policy and practices in China and in other countries are discussed to facilitate undergraduates in constructing music teacher role-identities.
Nutritional management and interventions in complications of pregnancy: A systematic review
Authors: Singh Jyoti , Kaur Mansehaj , Rasane Prasad , Kaur Sawinder , Kaur Jaspreet , Sharma Kartik , Gulati Amisha
Published: May 2023

Background: Pregnancy, also known as the “gestation period” which lasts for 37−40 weeks, has been marked as the period of “physiological stress” in a woman's life. A wide range of symptoms, from nausea to ectopic pregnancy, are usually aligned with risk factors like abortion, miscarriage, stillbirth, etc. An estimated total of 15% of total pregnant women face serious complications requiring urgent attention for safe pregnancy survival. Over the past decades, several changes in the environment and nutrition habits have increased the possibility of unfavourable changes during the gestation phase. The diagnostic factors, management and nutritional interventions are targeted and more emphasis has been laid on modifying or managing the nutritional factors in this physiologically stressed phase. Aims: This review focuses on dietary modifications and nutritional interventions for the treatment of complications of pregnancy. Nutritional management has been identified to be one of the primary necessities in addition to drug therapy. It is important to set a healthy diet pattern throughout the gestation phase or even before by incorporating key nutrients into the maternal diet. Methods: The published literature from various databases including PubMed, Google Scholar and ScienceDirect were used to establish the fact of management and treatment of complications of pregnancy. Results: The recommendations of dietary supplements have underlined the concept behind the eradication of maternal deficiencies and improving metabolic profiles. Conclusion: Therefore, the present review summarises the dietary recommendations to combat pregnancy-related complications which are necessary in order to prevent and manage the same.