bluuebunny/crossref_metadata_2025 huggingface dataset:
A computational model of liver tissue damage and repair
Authors: Adhyapok Priyom , Fu Xiao , Sluka James P. , Clendenon Sherry G. , Sluka Victoria D. , Wang Zemin , Dunn Kenneth , Klaunig James E. , Glazier James A.
Published: December 2020

Drug induced liver injury (DILI) and cell death can result from oxidative stress in hepatocytes. An initial pattern of centrilobular damage in the APAP model of DILI is amplified by communication from stressed cells and immune system activation. While hepatocyte proliferation counters cell loss, high doses are still lethal to the tissue. To understand the progression of disease from the initial damage to tissue recovery or death, we computationally model the competing biological processes of hepatocyte proliferation, necrosis and injury propagation. We parametrize timescales of proliferation (α), conversion of healthy to stressed cells (β) and further sensitization of stressed cells towards necrotic pathways (γ) and model them on a Cellular Automaton (CA) based grid of lattice sites. 1D simulations show that a smallα/β(fast proliferation), combined with a largeγ/β(slow death) have the lowest probabilities of tissue survival. At largeα/β, tissue fate can be described by a criticalγ/β*ratio alone; this value is dependent on the initial amount of damage and proportional to the tissue sizeN. Additionally, the 1D model predicts a minimum healthy population size below which damage is irreversible. Finally, we compare 1D and 2D phase spaces and discuss outcomes of bistability where either survival or death is possible, and of coexistence where simulated tissue never completely recovers or dies but persists as a mixture of healthy, stressed and necrotic cells. In conclusion, our model sheds light on the evolution of tissue damage or recovery and predicts potential for divergent fates given different rates of proliferation, necrosis, and injury propagation.
Intellectual disability-associated gain-of-function mutations in CERT1 that encodes the ceramide transport protein CERT
Authors: Murakami Hiroaki , Tamura Norito , Enomoto Yumi , Shimasaki Kentaro , Kurosawa Kenji , Hanada Kentaro
Published: December 2020

Intellectual disability (ID) is a developmental disorder that includes both intellectual and adaptive functioning deficits in conceptual, social, and practical domains. Although evidence-based interventions for patients have long been desired, their progress has been hindered due to various determinants. One of these determinants is the complexity of the origins of ID. The ceramide transport protein (CERT) encoded by CERT1 mediates inter-organelle trafficking of ceramide for the synthesis of intracellular sphingomyelin. Utilizing whole exome sequencing analysis, we identified a novel CERT variant, which substitutes a serine at position 135 (S135) for a proline in a patient with severe ID. Biochemical analysis showed that S135 is essential for hyperphosphorylation of a serine-repeat motif of CERT, which is required for down-regulation of CERT activity. Amino acid replacements of S135 abnormally activated CERT and induced an intracellular punctate distribution pattern of this protein. These results identified specific ID-associated CERT1 mutations that induced gain-of-function effects on CERT activity. These findings provide a possible molecular basis for not only new diagnostics but also a conceivable pharmaceutical intervention for ID disorders caused by gain-of-function mutations in CERT1.
StationRank: Aggregate dynamics of the Swiss railway
Authors: Anagnostopoulos Georg , Moosavi Vahid
Published: December 2020

Increasing availability and quality of actual, as opposed to scheduled, open transport data offers new possibilities for capturing the spatiotemporal dynamics of railway and other networks of social infrastructure. One way to describe such complex phenomena is in terms of stochastic processes. At its core, a stochastic model is domain-agnostic and algorithms discussed here have been successfully used in other applications, including Google’s PageRank citation ranking. Our key assumption is that train routes constitute meaningful sequences analogous to sentences of literary text. A corpus of routes is thus susceptible to the same analytic tool-set as a corpus of sentences. With our experiment in Switzerland, we introduce a method for building Markov Chains from aggregated daily streams of railway traffic data. The stationary distributions under normal and perturbed conditions are used to define systemic risk measures with non-evident, valuable information about railway infrastructure.
Taxonomic classification of strain PO100/5 shows a broader geographic distribution and genetic markers of the recently described Corynebacterium silvaticum
Authors: Viana Marcus Vinicius Canário , Profeta Rodrigo , da Silva Alessandra Lima , Hurtado Raquel , Cerqueira Janaína Canário , Ribeiro Bruna Ferreira Sampaio , Almeida Marcelle Oliveira , Morais-Rodrigues Francielly , Soares Siomar de Castro , Oliveira Manuela , Tavares Luís , Figueiredo Henrique , Wattam Alice Rebecca , Barh Debmalya , Ghosh Preetam , Silva Artur , Azevedo Vasco
Published: December 2020

The bacterial strain PO100/5 was isolated from a skin abscess taken from a pig (Sus scrofa domesticus) in the Alentejo region of southern Portugal. It was identified as Corynebacterium pseudotuberculosis using biochemical tests, multiplex PCR and Pulsed Field Gel Electrophoresis. After genome sequencing and rpoB phylogeny, the strain was classified as C. ulcerans. To better understand the taxonomy of this strain and improve identification methods, we compared strain PO100/5 to other publicly available genomes from C. diphtheriae group. Taxonomic analysis reclassified it and three others strains as the recently described C. silvaticum, which have been isolated from wild boar and roe deer in Germany and Austria. The results showed that PO100/5 is the first sequenced genome of a C. silvaticum strain from livestock and a different geographical region, has the unique sequence type ST709, and could be could produce the diphtheriae toxin, along with strain 05–13. Genomic analysis of PO100/5 showed four prophages, and eight conserved genomic islands in comparison to C. ulcerans. Pangenome analysis of 38 C. silvaticum and 76 C. ulcerans genomes suggested that C. silvaticum is a genetically homogeneous species, with 73.6% of its genes conserved and a pangenome near to be closed (α > 0.952). There are 172 genes that are unique to C. silvaticum in comparison to C. ulcerans. Most of these conserved genes are related to nutrient uptake and metabolism, prophages or immunity against them, and could be genetic markers for species identification. Strains PO100/5 (livestock) and KL0182T (wild boar) were predicted to be potential human pathogens. This information may be useful for identification and surveillance of this pathogen.
Identification and similarity analysis of aroma substances in main types of Fenghuang Dancong tea
Authors: Li Zhangwei , Wang Juhong
Published: December 2020

Fenghuang Dancong tea covers the oolong tea category and is widely acknowledged for its unique floral and honey flavor. In order to characterize the volatile components in nine different aroma types of Fenghuang Dancong tea, the Headspace solid-phase microextraction (HS-SPME) coupled with gas chromatography-mass spectrometry (GC- MS) were employed. In addition, the similarity analysis and cluster analysis (CA) were performed to compare the aroma characteristics and establish the correlation between the nine types of teas. The principal component analysis (PCA) and orthogonal partial least squares discrimination analysis (OPLS-DA) method were employed to determine the volatile components with a high contribution to the overall aroma of each type of tea. The results presented a total of 122 volatile aroma components including 24 kinds of alcohol, 23 kinds of esters, 15 kinds of olefins, 12 kinds of aldehydes, 12 kinds of ketones, 13 kinds of alkanes and 23 kinds of other components from the nine types of Fenghuang Dancong tea. Of these volatile aroma components, 22 types were common with linalool, dehydrolinalool, linalool oxide I, linalool oxide II, etc. The similarity of the nine types of Fenghuang Dancong tea was found between 46.79% and 95.94%. The CA indicated that the nine types of Fenghuang Dancong tea could be clustered into four categories when the ordinate distance reached to 10. The PCA demonstrated that decane, octadecane, 2,2,4,6,6-pentamethylheptane, dehydrolinalool, geraniol and nerol were the important aroma components to Fenghuang Dancong Tea. OPLS-DA proved that 2,2,4,6,6-pentamethylheptane, dehydrolinalool, phenylacetaldehyde, nerolidol, linalool oxide I and hexanal were the key differential compounds between the various types of tea samples. This study provides a theoretical basis for characterizing the volatile aroma components in the main types of Fenghuang Dancong tea as well as the similarity and correlation between various types of Fenghuang Dancong tea.
Positive association of angiotensin II receptor blockers, not angiotensin-converting enzyme inhibitors, with an increased vulnerability to SARS-CoV-2 infection in patients hospitalized for suspected COVID-19 pneumonia
Authors: Georges Jean-Louis , Gilles Floriane , Cochet Hélène , Bertrand Alisson , De Tournemire Marie , Monguillon Victorien , Pasqualini Maeva , Prevot Alix , Roger Guillaume , Saba Joseph , Soltani Joséphine , Koukabi-Fradelizi Mehrsa , Beressi Jean-Paul , Laureana Cécile , Prost Jean-François , Livarek Bernard
Published: December 2020

Background

Angiotensin-converting enzyme 2 is the receptor that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses for entry into lung cells. Because ACE-2 may be modulated by angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs), there is concern that patients treated with ACEIs and ARBs are at higher risk of coronavirus disease 2019 (COVID-19) pneumonia.

Aim

This study sought to analyze the association of COVID-19 pneumonia with previous treatment with ACEIs and ARBs.

Materials and methods

We retrospectively reviewed 684 consecutive patients hospitalized for suspected COVID-19 pneumonia and tested by polymerase chain reaction assay. Patients were split into two groups, according to whether (group 1, n = 484) or not (group 2, n = 250) COVID-19 was confirmed. Multivariable adjusted comparisons included a propensity score analysis.

Results

The mean age was 63.6 ± 18.7 years, and 302 patients (44%) were female. Hypertension was present in 42.6% and 38.4% of patients in groups 1 and 2, respectively (P = 0.28). Treatment with ARBs was more frequent in group 1 than group 2 (20.7% vs. 12.0%, respectively; odds ratio [OR] 1.92, 95% confidence interval [CI] 1.23–2.98; P = 0.004). No difference was found for treatment with ACEIs (12.7% vs. 15.7%, respectively; OR 0.81, 95% CI 0.52–1.26; P = 0.35). Propensity score-matched multivariable logistic regression confirmed a significant association between COVID-19 and previous treatment with ARBs (adjusted OR 2.36, 95% CI 1.38–4.04; P = 0.002). Significant interaction between ARBs and ACEIs for the risk of COVID-19 was observed in patients aged > 60 years, women, and hypertensive patients.

Conclusions

This study suggests that ACEIs and ARBs are not similarly associated with COVID-19. In this retrospective series, patients with COVID-19 pneumonia more frequently had previous treatment with ARBs compared with patients without COVID-19.
stepping stone for postgraduate research? Assessing the place of the honours degree in the Health Science curriculum
Authors: Kool Bridget , Haysom Samuel , Newcombe David , Carter Susan
Published: December 2020

Research honours degrees provide potential pathways into Masters and Doctorate degrees. Essential to their success is that they provide a sound grounding for novice researchers without taxing supervisors unduly. Our case study is a Bachelor Health Science (BHSc) (Hons) degree at the University of Auckland, New Zealand, a postgraduate degree aimed at attracting high-achieving BHSc graduates to study at an advanced level. This particular programme is not practice focused, but is a training ground for research. Therefore assessing whether the honours programme is a good investment for students meeting their needs and in preparing them for future study, and is a viable undertaking for often already over-committed supervisors is important. The overarching aim of this case study is to explore how to evaluate whether an honours programme provides a sound grounding for further research based postgraduate study. Graduates of the BHSc (Hons) programme (completed 2010 – 2014) and academics at the University of Auckland were invited to take part in online anonymous cross-sectional surveys. A total of 26 graduates and 23 academics completed the surveys. Overall graduates reported they were satisfied with the quality of the honours programme (73%; 19/26), found the programme to be intellectually stimulating (92%; 24/26), motivating (73%; 19/26) and overall worthwhile (85%; 22/26). Academics agreed that the programme was worthwhile (78%; 18/23), and that the programme adequately prepared graduates for future postgraduate study (65%; 15/23). This case study has found that the BHSc (Hons) programme is an effective launching pad for future postgraduate study; however, the findings have highlighted directions for future improvement in curriculum design. The study gave insights into the challenges, benefits and limitations perceived by academics involved in supervision and graduates completing the programme. Those designing postgraduate honours degrees as researcher training grounds may find this paper useful.
Students’ attention in class: patterns, perceptions of cause and a tool for measuring classroom quality of life
Authors: Allison Neil Grainger
Published: December 2020

Constructs such as engagement and FLOW have been well-developed and studied in education contexts. Sustained attention, a distinct but related concept, has been less studied, particularly in the language classroom and foreign language medium education. In a case study involving mixed methods, predominantly structured qualitative data, student attention was measured repeatedly during a university pre-sessional EAP course. The aim was to compare with previous research on the relationship between attention and time/stages of lessons and reveal any additional attention patterns based on interaction types (group work, individual work, full class). In addition, repeated surveys were used to reveal what students perceived as damaging to attention and also the perceived value of exercise breaks. Results suggested significance in attention changes over time and between teacher talking time, group work and individual interaction types. The study design itself forms a simple and effective tool to improve classroom life including teachers’ monitoring of class dynamics and for students, a means of self-reflection to increase learning performance.
Precificação de fretes rodoviários via modelos paramétricos
Authors: Coppe Luísa Maia , Diniz Diego Augusto , Carvalho Vyctor Henrique de , Pimentel Lívia Martins da Costa Furtado
Published: December 2020

O transporte pode representar, dentro da estrutura de custos dos produtos, até 60% do seu valor total. No Brasil o modal rodoviário é o mais utilizado, configurando 61% dos fretes realizados. A precificação do transporte rodoviário, no entanto, não é um processo trivial por envolver variáveis que vão além dos custos básicos da atividade. O objetivo deste trabalho é o desenvolvimento de um modelo de precificação de fretes com maior grau de precisão e tempo de resposta reduzido, utilizando técnicas de regressão linear múltipla. O estudo é aplicado a uma empresa de operação logística cujo modelo de negócios é a conexão entre o transportador e o demandante do frete. O modelo de precificação desenvolvido obteve um coeficiente de determinação de 16R2=0,9966"> . Isto é, um modelo altamente explicativo, visto que explica 99,66% da variabilidade dos valores de fretes observados. As variáveis preditoras que compõem o modelo são: distância, custo do motorista, tipo de cliente, valor da nota fiscal, origem e destino. Com o modelo desenvolvido, as variáveis tiveram seu peso estatisticamente calculado, conferindo automatização ao processo e tornando mais ágil a rotina dos analistas da empresa.
Comparing self-determination theory and the L2 motivational self system and their relationships to L2 proficiency
Authors: Takahashi Chika , Im Seongah
Published: December 2020

This study empirically compares two often-utilized motivation theories in L2 studies: self-determination theory and the L2 motivational self system. It also examines the relationships among their motivational constructs, learners’ intended L2 learning effort, and L2 proficiency. While a number of studies have utilized these models in order to examine second language learners’ motivation, there has not been a thorough comparison of the two. Furthermore, while many studies have demonstrated the structural relationships between the motivational constructs of the two theories and the learner’s self-reported amount of effort, fewer studies have examined their L2 achievement. The results of this study indicated that the constituents in the two theories are correlated as predicted. Furthermore, while internalized types of motivation in self-determination theory predicted intended learning effort, which then led to L2 proficiency, the strength of the ideal L2 self was much weaker than the L2 learning experience, unlike what is argued in the theory.
LOS DERECHOS HUMANOS Y LOS DEPORTES JUVENILES
Authors: MELNIKOV Vitaly
Published: December 2020

El presente trabajo pretende, a partir de la información recogida en la documentación de diversas estructuras internacionales, mostrar la importancia del deporte en el colectivo juvenil como un Derecho Humano fundamental en el panorama internacional. Asimismo, se recoge el papel fundamental que han tenido las estructuras olímpicas en el desarrollo del deporte para este colectivo, enfatizando la importancia de valores como la amistad, las relaciones culturales internacionales, el respeto y la tolerancia, más allá de los resultados deportivos; todo ello con el objetivo de formar a la juventud mundial y conseguir la paz universal. El presente trabajo presenta así una revisión de las diversas ediciones deportivas nacionales e internacionales y su evolución, mostrando un incremento positivo en todos los casos. Por último, se expone de manera detallada uno de los eventos deportivos que se creó y evolucionó con la misma finalidad olímpica citada: El Foro Internacional de Jóvenes Olímpicos de Rusia, que se llevó a cabo con el fin de proteger a los atletas de los actuales fenómenos negativos del deporte y en particular del dopaje.
Characteristics of bird's visible migrations at the Dniester Delta in 1974-1976
Authors:   Azov-Black Sea Interdepartmental Ornithological Station of Shmaihauzen Institute of Zoology and Melitopol State Prdagogical University named by Bohdan Khmelnitsky, Chernichko I. I.
Published: December 2020

The article deals with the results of observations of diurnal bird migrations and counts on a fixed route in the spring and autumn of 1974-1976, in the Dniester Delta. The total number of observation days was 82 (32 in spring and 50 in autumn, respectively). For this period, during observations and counts on the route, 135 bird species from 11 orders were registered, the total number of which exceeded 600 000 individuals. The study of migrations was carried out according to the E. Kumari method (1955). At the observation site, 80 species were counted, including 52 in spring and 60 in autumn. The Jaccard similarity coefficient (Jaccard index) was quite low between seasons and amounted to only 0.59. The frequency of occurrence of the majority of registered species was low. This may have been due to the area of the floodplains themselves, as well as to the weak extent of their anthropogenic transformation observed in the late 70s of the 20th century, which contributed to the bird migrations over the Delta in a wide front. The density of the spring migration flow was maximum in March and averaged 1077.4 ind. (n=32) per a daylight, while the autumn migration flow was 1926.2 ind. (n=50). There were interannual differences in the density of migrations in March. In the spring of 1975, the flight density was 900.3 ind. (n=15), and in 1976 it was almost twice more and amounted to 2094.7 ind. (n=11). There were no interannual differences in the intensity of autumn migrations. The maximum migration density was 2585.2 ind. (n=23) in October. The majority of non-passerine bird species flew in the morning: in spring up to 43.8%, in autumn - 64.1%. The diurnal activity of Passeriformes varied by season: in spring, morning migrations prevailed (56.1%), and in autumn, with the same ratio in the evening (56.1%). The vast majority of flocks (87 - 90%) amounted from 1 to 50 individuals. At altitudes up to 50 m, 37.0% flew, 51-150 m – 24.9% and above 150 m – 38.1% of birds. For a number of species, it was proved that the height of their flights in the general for the season migration sector of directions was higher than in the reverse directions.127 bird species were registered on all routes, of which 106 were registered on a permanent (fixed) route. Maximum species diversity was observed in March – 85, in April − 65, in September − 60, in October − 61 and in November – 40 species. The dynamics of the species composition of birds on a fixed route can be used as an additional characteristic of day transit migrations.
Object Relations as "Whole General Effect" in Management
Authors:   National University of Bioresources and Use of Natural resources of Ukraine, Morozov O.F. , Shevchenko M.M. ,   Presidium of the NAS of Ukraine
Published: December 2020

Introduction. The socio-economic structure and the structure of economic production in Ukraine are get increasingly subjected to the consumption of goods and services. Problem Statement. In the outlined conditions, the problem is that in most cases, the economy has been already controlling the human being, not vice versa. Purpose. The development of a systematic approach to the problem of revealing the essence of the relationship between the “subject” of economic space management, the human being, and the “object” of management, the economic space, in order to find ways to return to human-centered socio-economic structure of the country. Materials and Methods. For the first time, a new concept of “social effect” has been introduced. It is an analog of the well-known lexicographic effect proposed at the beginning of the 21st century by Full Member of the NAS of Ukraine V. Shirokov, which may be regarded as a phenomenological framework of the theory of complexity and the corresponding specific theory of economic information, on the one hand. On the other hand, the complexity theory, the Kolmogorov information, and the Levenheim-Skolem theorem may be considered formal correlates of the lexicographic effects in economic systems. Results. This approach is considered system-creating to describe the holistic processes of relations of economic systems of five levels with the phenomenal property of self-compensation of complexity. The separation of structural, substantive, and subjective properties, as well as the relationships between them gives the analyzed economic reality the property of being a system. Conclusions. Based on the above assumptions and general theoretical and informational ideas about socio-economic systems of five levels as formal correlates of the lexicographic effect, it has been proposed to coordinatize and to unify information in the economic space of these management systems as a basis for establishing the “source — form — content” equilibrium in accordance with the rule of "common goals".
High-frequency ultrasound in the 21st century
Authors:   Ultrasound Diagnostic Department Faculty of Medical Sciences, Medical University of Warsaw, Warsaw, Poland, Mlosek Robert Krzysztof , Migda Bartosz ,   Ultrasound Diagnostic Department Faculty of Medical Sciences, Medical University of Warsaw, Warsaw, Poland, Migda Michał ,   Clinical Unit of Obstetrics, Women’s Disease and Gynecological Oncology, United District Hospital, Collegium Medicum University of Nicolaus Copernicus in Torun, Torun, Poland
Published: December 2020

The beginnings of skin ultrasound date back to about 50 years ago. However, the dynamic progress of skin ultrasound took place in the last twenty years, when the unprecedented development of computer technologies occurred, which resulted in the popularization of and easier access to modern ultrasound equipment. Skin tests can be performed with both classic scanners equipped with broadband transducers with a minimum frequency of 15 MHz, and specially dedicated skin systems with high-frequency scanners, which are equipped with mechanical transducers with a frequency of 20 MHz to up to 100 MHz. Owing to technologically advanced machines, ultrasonography has proved to be useful in many areas. The aim of this study was to present the current knowledge and possibilities of skin imaging using highfrequency ultrasonography. Te paper discusses technical aspects, types of devices available on the market, as well as methods for the analysis of ultrasound skin images and parameters useful in their interpretation. We also present current applications of skin ultrasound, with particular emphasis on dermatology and aesthetic medicine. In the field of dermatology, we discussed imaging of focal lesions as well as an assessment of pathologically changed skin and treatment monitoring. We also focused on the use of high-frequency ultrasonography in aesthetic medicine and cosmetology. The popularity of this method is constantly growing in these fields, and ultrasound is now used in everyday practice to assess the skin, plan and monitor procedures, as well as to treat potential complications. High-frequency ultrasonography is a highly effective method for skin evaluation, although still underappreciated in may fields. Further research is needed to standardize this modality, as well as to implement training for operators, and to popularize this imaging technique.
High frequency ultrasound assessment of labial glands simulating small nodules or granulomas after lip augmentation
Authors: Skrzypek Ewa , Mlosek Robert Krzysztof
Published: December 2020

Aim of the study: The aim of this study is to evaluate the utility of high-frequency ultrasound in the assessment of the nature and differentiation of lumps occurring in the labial mucosa after lip filling procedures. Material and methods: The study sample included 5 women aged from 28 to 43 years (mean age: 37.4 years) who previously underwent a lip augmentation or rejuvenation procedure. Photographic documentation was taken and high-frequency ultrasound assessment was performed in all the patients. The presence of deposits, foreign body granulomas, fibrosis and labial glands was mainly investigated taking into account the shape of the abnormalities, their margins, surface area, location and echogenicity. In order to confirm the diagnosis, histopathological examination was performed. Results: The examinations performed made it possible to differentiate between granulomas and persistent deposit nodules and to demonstrate the presence of massive fibrosis and of labial glands pushed out by these abnormalities with the glands presenting as hypoechoic oval areas. Histopathological examination confirmed the morphology of labial glands reported by the patients as uncomfortable lumps felt from the side of the mucosa, which clinically simulate persistent deposit nodules or granulomas. Conclusions: High-frequency ultrasound is a method that is essential for the correct differentiation between complications of tissue filler procedures. This, in turn, makes it possible to apply the right treatment. In this study, it was demonstrated for the first time that the lumps reported by patients who have had a lip filling procedure may be the result of labial glands being pushed out by deposits, granulomas or massive fibrosis, which are complications of such procedures.
The use of high-frequency skin ultrasound in the diagnosis of lipodermatosclerosis
Authors:   First Department of General and Vascular Surgery, Faculty of Medicine, Medical University of Warsaw, Poland, Woźniak Witold , Danowska Anna ,   First Department of General and Vascular Surgery, Faculty of Medicine, Medical University of Warsaw, Poland, Mlosek Robert K. ,   Ultrasound Diagnostic Department Faculty of Medical Sciences, Medical University of Warsaw, Warsaw, Poland
Published: December 2020

Introduction: Lipodermatosclerosis is a symptom of severe venous insufficiency, the diagnosis of which is based on the clinical picture. Although the histopathology of the skin and the subcutaneous tissue allows for the most reliable diagnosis, it is not recommended due to healing disorders. Aim: The aim of this study was to assess the usefulness of high-frequency ultrasound in the diagnosis of lipodermatosclerosis. Materials and methods: The study included 10 patients with lipodermatosclerosis who underwent Duplex Doppler ultrasound of lower limb veins, high-frequency ultrasound of the tibial skin, and radiography of the lower leg, all of which were analyzed in correlation with clinical symptoms. Results: The study group included 9 women and 1 man aged 39–81 years. Manifestations of lipodermatosclerosis were detected in 14 limbs. High-frequency ultrasound showed that the mean dermis thickness at the affected sites was 2.63 mm, and was significantly thicker compared to healthy skin (1.45 mm) (p = 0.00002). Higher echogenicity was detected in the affected body regions in 85.7% of cases for the skin and 92.9% of cases for the subcutaneous tissue. Subcutaneous and vascular wall calcifications were detected in 92.9% and 78.6% of cases, respectively. Fibrosis was observed in all limbs, and compression sonoelastography showed that the compliance of the subcutaneous tissue was lower than that of muscles. The border between the skin and the subcutaneous tissue was blurred in 57.1% of cases. Radiography revealed thickening of the affected skin regions in all limbs, with calcifications detected in 85.7% of cases. A blurred border between the skin and the subcutaneous tissue was observed in 35.7% of limbs. Conclusion: High-frequency ultrasonography of the skin and the subcutaneous tissue in the lower legs supported with radiological findings is highly useful in the diagnosis of lipodermatosclerosis.
A case of incidental infantile gallbladder adenomyomatosis: an unusual US finding of uncertain clinical significance
Authors:   Consultant Radiologist, Department of Anatomy, European University of Cyprus Medical School, Nicosia, Cyprus, Drakonaki Elena , Kokkinakis Stamatios ,   School of Medicine, University of Crete, Greece, Karageorgiou Ioannis ,   School of Medicine, University of Crete, Greece, Maliotis Neofytos ,   School of Medicine, University of Crete, Greece, Ioannidoy Anna ,   Asklepeion General Clinic, Heraklion, Greece, Symvoulakis Emmanouil K. ,   Department of Social Medicine, School of Medicine, University of Crete, Greece
Published: December 2020

Adenomyomatosis of the gallbladder is defined as hypertrophy of the gallbladder mucosal epithelium that invaginates into a thickened muscularis propria, leading to the formation of intramural diverticula. It is typically considered a benign condition most commonly affecting adults and, rarely, children. In this case report, we present a case of gallbladder adenomyomatosis in a 3-month-old infant. The diagnosis was made incidentally on ultrasound examination of the abdomen, in an otherwise asymptomatic child with no laboratory test abnormalities and no underlying disease. The purpose of this case report is to make infantile adenomyomatosis and its implications known to clinicians, as the literature on this topic is limited. To the best of our knowledge, this is the youngest reported case of adenomyomatosis in the pediatric population.
Primary breast aspergillosis mimicking breast malignancy – a rare case report
Authors:   Department of Pathology, Bielanski Hospital, Warsaw, Poland, Faryna Jan , Łuczyszyn Izabela ,   Department of Pathology, Bielanski Hospital, Warsaw, Poland, Kleszczewski Andrzej ,   Centrum Medyczne Saska Kępa NZOZ, Warsaw, Poland, Kleszczewska Jolanta ,   Centrum Medyczne Saska Kępa NZOZ, Warsaw, Poland
Published: December 2020

Aspergillus is a group of saprophytic fungi which is widely present in our environment. It can be a cause of opportunistic infections of different organs, especially the lungs. Fungal mastitis is a rare infection in healthy subjects. It is seen in breastfeeding females and immunodeficient patients. We herein report a rare presentation of aspergilloma in a 73-year-old female who presented with a palpable mass in the breast. She was under medical control due to plasmocytoma. In ultrasound examination the lesion was classified as BI-RADS 4b and subsequently biopsy (fine needle and core needle aspiration) was performed. Biopsy provided immediate results and excluded breast cancer. In this rare case report of breast aspergillosis, we emphasize the role of pathology in medical diagnosis.
Development of an appearance validity instrument for educational technology in health
Authors: Souza Ana Célia Caetano de , Moreira Thereza Maria Magalhães , Borges José Wicto Pereira
Published: December 2020

ABSTRACT Objectives: to develop and evaluate the convergence of the instrument for the appearance validity of educational technologies in health. Methods: methodological study conducted in two steps. In step 1, the instrument items were developed, with subsequent content validity by nine specialists in the development of educational technologies in health. In step 2, the convergent validity between another instrument and the appearance instrument was performed. Correlation results above r> 0.3 and p <0.05 were considered as plausible convergent validity. Results: the ten items of the initial version of the appearance instrument were submitted to content validity that resulted in a final version with 12 items (Content Validity Index = 0.93). The correlation indexes were strong with the objective and appearance domains; moderate with motivation, organization and total; and weak with writing style. Conclusions: the appearance instrument demonstrated content validity and convergent validity, in addition to a strong correlation with the other instrument.
Development and validation of a technology for obstetric intraoperative care safety
Authors: Lugão Nátale Carvalho de Souza , Brandão Marcos Antônio Gomes , Silva Rafael Celestino da
Published: December 2020

ABSTRACT Objectives: to develop and validate an obstetric surgical safety checklist for intraoperative care. Methods: this is a methodological study with two phases: integrative review in databases, using selection criteria and descriptors to synthesize the evidence and develop the checklist; checklist content validation, with 37 judges, who answered a Likert-type questionnaire. For analysis, a >85% content validation index was applied. Results: the checklist’s first moment reached a 96.1 content validation index; the second moment, 95.5; the third moment, 98.9. Thus, the validation index of all verifying sections present in the three surgical moments was 97.1. Cronbach’s Alpha value was 95.57%. Conclusions: the checklist items were validated by judges, with improvement of some items and insertion of others.
Care in pediatric oncology: a cross-sectional analysis of the quality of life of nursing professionals
Authors: Souza Raíssa Silva , Araújo Fernanda Lopes de , Manzo Bruna Figueiredo , Marcatto Juliana de Oliveira , Montenegro Lívia Cozer , Silva Paulo Roberto Mendonça , Simão Delma Aurélia da Silva
Published: December 2020

ABSTRACT Objectives: to assess and correlate sociodemographic and work variables with the quality of life (QoL) of nursing professionals who work with children and adolescents with cancer. Methods: a cross-sectional, analytical, correlational study with 123 volunteers from a public hospital. Sociodemographic characterization questionnaire and WHOQOL-Bref have been used. Results: “sex” (p=0.017), “work shift” (p=0.022), “employment relationship” (p=0.049) “having children” (p=0.002), “work sector” (p=0.047), “work shift” (p=0.007) and “employment relationship” (p=0.040) had worse quality of life. “Job duty length” (p=0.027) and “years of study” (p=0.001) and, conversely, “age” (p=0.004) and “job tenure” (p=0.001) were positively correlated with quality of life domains. Conclusions: most professionals rated the overall quality of life as “good”. Sociodemographic and work characteristics are associated with worse quality of life. The more years of study and the better job duty length the better the quality of life.
Construction and validation of a mobile application for development of nursing history and diagnosis
Authors: Melo Evandro Bernardino Mendes de , Primo Cândida Caniçali , Romero Walckiria Garcia , Sant’Anna Hugo Cristo , Sequeira Carlos Alberto da Cruz , Lima Eliane de Fátima Almeida , Fioresi Mirian
Published: December 2020

ABSTRACT Objectives: to describe the construction and validation process for a mobile application for development of the nursing history and diagnosis. Methods: methodological study conducted in 2018 in three stages: content creation, based on the Basic Human Needs categories and nursing diagnoses; content assessment by nine nursing judges, with calculation of the content validity index; and construction of the application, which included definition of the requirements, a conceptual map, implementation and prototyping options, tests and implementation. Results: the application was organized by sections: Grouped Basic Human Needs, Cranial pair tests, Clinical assessment scales and Additional tests. Two section were adjusted according to the judges’ suggestions. Final Considerations: it is the first application produced in Brazil based on the Basic Human Need categories, which enables quick access to information, concepts and typical nomenclatures of semiology, recording of clinical data and definition of nursing diagnoses.
Participative education with nurses: potentialities and vulnerabilities in the breast and cervical cancer tracking
Authors: Soares Lidia Santos , Silva Maria da Anunciação , Alves Hayda Josiane , Queiroz Ana Beatriz Azevedo , Brito Irma da Silva
Published: December 2020

ABSTRACT Objectives: to systematize permanent participatory education experience with Primary Care nurses on breast and cervical cancer screening, identifying potentialities and vulnerabilities. Methods: systematic account according to Holliday, in five stages: starting point, initial questions, recovery of the lived process, background reflection and arrival points. It was the product of two workshops with 96 nurses and analyzed in the light of the ministerial guidelines and Ayres’ concept of vulnerability. Results: the potentialities are related to the nurse’s work implementing the principles of the Unified Health System. The difficulties are complex and expose individual, contextual and programmatic vulnerabilities in the practice of screening. Final Considerations: permanent education and participatory pedagogical strategies allowed a wide and playful exchange of learning and the participation of a significant number of professionals. There is a need for studies on the institutionality of programmatic guidelines and nurses’ space to be the initiator of new practices within the scope of Primary Care.
Lean Six Sigma methodology application in health care settings: an integrative review
Authors: Zimmermann Guilherme dos Santos , Siqueira Luciola Demery , Bohomol Elena
Published: December 2020

ABSTRACT Objective: to analyze the scientific production on the results of Lean Six Sigma methodology in health care institutions. Methods: an integrative literature review, with the following question: what are the results in health institutions using Lean Six Sigma and Six Sigma methodology? The search was carried out at MEDLINE, LILACS, BDENF, CINAHL, Web of Science, and Scopus, with no time frame. Results: thirty-four articles were included, published between 2005 and 2019, of which 52.9% came from the United States of America. The most commonly found improvements were in hospital institutions and from the perspective of customers and internal processes. Conclusion: using Lean Six Sigma methodology proved to be effective in the different health care settings, evidencing a gap in its application regarding people engagement and training.
Hope-based interventions in chronic disease: an integrative review in the light of Nightingale
Authors: Laranjeira Carlos António , Querido Ana Isabel Fernandes , Charepe Zaida Borges , Dixe Maria dos Anjos Coelho Rodrigues
Published: December 2020

ABSTRACT Objective: To identify the available evidence in the scientific literature about the strategies or interventions used to promote hope in people with chronic diseases. Method: An integrative literature review of literature published between 2009-2019, which was conducted in online browsers/databases: b-On, EBSCO, PubMed, Medline, ISI, SciELO, PsycINFO, Google Scholar. Forty-one studies were found, of which eight met the inclusion criteria. Results: Most studies used a quantitative approach. There was a predominance of studies from Asia and America, addressing patients with multiple sclerosis, diabetes, congestive heart failure, and cancer. Hope-based interventions were categorized by the hope attributes: experiential process, spiritual/transcendence process, rational thought process, and relational process. Conclusion: Hope-based interventions, in its essence, are good clinical practices in the physical, psychological, social and spiritual domains. This is congruent with the vision of nursing, first proposed by Florence Nightingale. There seem to be gaps in the literature regarding specific hope promoting interventions.
CULTURAS DA INFÂNCIA: OS MODOS COMO AS CRIANÇAS ASSISTEM E INTERAGEM COM AS SÉRIES DE ANIMAÇÃO
Authors: NERY PATRÍCIA GONÇALVES , REGO TERESA CRISTINA
Published: December 2020

RESUMO: Na sociedade atual, inúmeros produtos e conteúdos midiáticos, apropriados e reelaborados criativamente pelas crianças em processos de interação com os pares e com os adultos, integram as chamadas culturas da infância. Dentre esses produtos culturais, as séries de animação veiculadas pela TV (aberta ou fechada) participam, com destaque, das experiências cotidianas das crianças. O objetivo deste artigo é apresentar a primeira parte dos resultados de uma investigação que buscou compreender os modos como as crianças assistem, interagem e significam as séries de animação. A pesquisa foi realizada no âmbito da investigação qualitativa e participativa, por meio de uma análise microssocial, de cunho interpretativo, integrada à área da Sociologia da Infância a qual se conjugou de forma interdisciplinar com os Estudos Culturais Latino-americanos da área da Comunicação. Realizada com um grupo de estudantes de nove e dez anos, a pesquisa examinou o ponto de vista das crianças a partir da utilização de estratégias metodológicas diversificadas que envolveram observação participante, entrevistas em pequenos grupos e oficinas de trabalho. Os resultados obtidos revelam, dentre outros aspectos, que as crianças não assimilam simplesmente ao que assistem como meras espectadoras passivas. Em multiconectividade com outras mídias, elas participam de um processo ativo, interativo e dialogal, sempre relacionado ao contexto sociocultural em que estão inseridas. Eles permitem apontar também a grande responsabilidade (nem sempre percebida ou reconhecida) envolvida na produção de conteúdos e produtos midiáticos para as crianças, de um modo geral, e, em particular, das séries de animação voltadas ao público infanto-juvenil.
A REVOLUÇÃO FRANCESA E A EDUCAÇÃO INTEGRAL NO BRASIL: DA CONCEPÇÃO AO CONCEITO
Authors: MACIEL ANTÔNIO CARLOS , BOTELHO ARMINDA RACHEL , SILVA CINTIA ADÉLIA DA
Published: December 2020

RESUMO: A partir de meados da primeira década dos anos 2000, intensificou-se no Brasil o debate sobre educação integral. Os partidários do “trabalho como princípio educativo” buscaram os fundamentos epistemológicos na concepção marxiana de educação; os diferentes estratos sociais do liberalismo mantiveram-se, no essencial, atrelados à relação entre educação e moral. Uns e outros, contudo, por razões ideológicas, sem explicitar a origem desses fundamentos. Este artigo tem como exato objetivo: demonstrar a origem epistemológica e política da concepção e dos conceitos de educação e de educação integral. Para tanto, utilizou-se da análise histórico-crítica (SAVIANI, 2003; MACIEL e BRAGA, 2008), metodologicamente fundada no materialismo histórico-dialético (MARX, 1983b) para perquirir a trajetória desses conceitos. Em função do método, parte-se da análise dos textos da I Internacional (MARX, 1976; BAKUNIN, 2003) para se chegar a Proudhon (2007) e, daí, por pistas que levam aos textos da Revolução Francesa (CONDORCET, 1792; LEPELLETIER, 1793) que, por sua vez, conduzem a Dewey (1979) e a Teixeira (1959). Como resultado dessa aventura, chega-se às seguintes conclusões: a partir da Revolução Francesa, as concepções de educação fundamentam-se nas dimensões intelectual, física e moral (exceto para Marx); em termos de educação pública, todas levam em consideração a formação para o trabalho, mas as liberais visam ao trabalho subalterno, enquanto que as socialistas, à emancipação. Tal diferença implica em definições antagônicas dos conceitos de educação e de educação integral.
Juventude negra, Ensino Médio e democracia: a luta pela escola
Authors: Corsino Luciano Nascimento , Zan Dirce Djanira Pacheco e
Published: December 2020

RESUMO O presente trabalho apresenta dados etnográficos de uma pesquisa de doutorado realizada em escola pública na zona norte de São Paulo. Na realidade pesquisada, as garotas negras tiveram um papel importante na organização e manutenção do movimento de ocupação ocorrido no final de 2015. Neste artigo, pretendemos evidenciar como a presença da cultura negra no currículo escolar de uma instituição de Ensino Médio, junto a outras políticas de valorização e reconhecimento dessa cultura, pode ter contribuído para a articulação dessas jovens na decisão sobre o movimento. A ocupação se deu em meio a uma movimentação maior ocorrida no estado de São Paulo em 2015, tendo como principais objetivos: a) resistir à reforma do Ensino Médio anunciada pela Secretaria de Educação do Estado de São Paulo e b) reivindicar uma escola mais democrática, que reconheça as diferenças e possibilite a participação das jovens nos processos de decisão. A pesquisa realizada nessa unidade escolar tem como fundamentação teórica os estudos da sociologia da educação e os estudos antirracistas. Realizou-se, através de observações e entrevistas semiestruturadas com estudantes e docentes antes, durante e após o período de ocupação. Percebe-se que apesar das dificuldades, como perseguições à docentes e estudantes que participaram e apoiaram o movimento, o processo de ocupação contribuiu para a constituição de saberes fundamentais para a construção de um pensamento democrático, antirracista e feminista na instituição.