bluuebunny/crossref_metadata_2025 huggingface dataset:
Characteristics of Composite Deprivation Indices Used in Public Health: A Scoping Review Protocol
Authors: Zelenina Anastasia , Shalnova Svetlana , Maksimov Sergey , Drapkina Oksana
Published: August 2022

Introduction: A deprivation index has become a more popular tool to rank levels of deprivation within different geographic areas. It is extensively used for monitoring health inequalities, evaluating health care services, developing and modifying health policies and programs, and allocating health resources equitably. Our objectives are (1) to explore the relevant literature to describe features of composite deprivation measures; (2) create a list and classification of original deprivation indices. We will develop the classification of indices to systematize knowledge and improve the functional utility of the information. Methods: Any original deprivation index mentioned in peer-reviewed or grey literature documents will be eligible for inclusion if it assesses deprivation at a population level and used in relation to health. The study area will be limited to the geographic areas of North America, Europe, Australia, and New Zealand. Tables and a narrative summary will be used to describe features of deprivation indices. Diagrammatic form will be used to create the classification of deprivation indices. Discussion: Practically, the results of this study could facilitate finding a common language among researchers and specialists who create and use deprivation indices, thus helping the development and implementation of appropriate deprivation indices for different countries.
Parent-Adolescent Conflict, Depressive Symptoms, and Non-Suicidal Self-Injury among Chinese Adolescents: The Moderating Effect of the COMT Gene rs4680 Polymorphism
Authors: Deng Yuting , Li Meijin , Wang Huahua , Li Jingjing , He Xu , Yu Chengfu
Published: August 2022

Existing research suggests that parent-adolescent conflict is associated with increased risk for adolescent non-suicidal self-injury (NSSI). However, adolescent NSSI reactions to parent-adolescent conflicts exhibit large individual differences. This study sought to explore whether depressive symptoms mediates the relationship between parent-adolescent conflict and adolescent NSSI, and whether this mediating process is moderated by the COMT gene rs4680 polymorphism. A total of 673 adolescents (364 males, 309 females) in the age range of 12 to 15 years (Meanage = 12.81 years, SD = 0.48) completed questionnaires regarding parent-adolescent conflict, depressive symptoms, and NSSI. Genomic DNA was extracted from saliva and buccal cells from each participant. Bootstrapping techniques displayed statistically significant moderated mediation. The results showed that the positive association between parent-adolescent conflict and adolescent NSSI was in fact mediated by depressive symptoms. Moreover, this indirect link was moderated by the COMT gene rs4680 polymorphism. Specifically, the risk effect of parent-adolescent conflict on adolescent NSSI via depressive symptoms was stronger for adolescents with Val/Val genotype than for those with Met/Met or Val/Met genotype. These findings underscore the importance of examining the interaction between genes and the environment to understand how and when parent-adolescent conflict impacts adolescent NSSI.
Proposal of a Method for the Analysis of Sentiments in Social Networks with the Use of R
Authors: Villegas-Ch. William , Molina Sofía , Janón Víctor De , Montalvo Estevan , Mera-Navarrete Aracely
Published: August 2022

Decision making is vital for the management of all organizations. For this reason, data analysis has become one of the fastest-growing technologies when it comes to generating information and knowledge about data generated by organizations. However, data generation is not limited to traditional sources. On the contrary, emerging technologies and social networks have become non-traditional sources that provide large volumes of data that can be exploited using different data analysis methods. Here, the objective is to determine the feelings of the population toward a brand, a product, or a service and to even identify the reactions of people to events and trends generated in their environment. Sentiment analysis, for organizations and social groups, has become a necessity that must be covered to identify the acceptance of an idea or its management. Therefore, this work proposes a method for the analysis of sentiment in social networks in such a way that it adapts to the needs of organizations or sectors, and the acceptance or rejection of the population can be efficiently identified from what is exposed in a social network.
Changes in the Host Gut Microbiota during Parasitization by Parasitic Wasp Cotesia vestalis
Authors: Zhang Shuaiqi , Huang Jieling , Wang Qiuping , You Minsheng , Xia Xiaofeng
Published: August 2022

Parasites attack the host insects and possibly impact the host-gut microbiota, which leads to provision of a suitable host environment for parasites’ development. However, little is known about whether and how the parasitic wasp Cotesia vestalis alters the gut microbiota of the host Plutella xylostella. In this study, 16S rDNA microbial profiling, combined with a traditional isolation and culture method, were used to assess changes in the bacterial microbiome of parasitized and non-parasitized hosts at different developmental stages of C. vestalis larvae. Parasitization affected both the diversity and structure of the host-gut microbiota, with a significant reduction in richness on the sixth day post parasitization (6 DPP) and significant differences in bacterial structure between parasitized and non-parasitized hosts on the third day. The bacterial abundance of host-gut microbiota changed significantly as the parasitization progressed, resulting in alteration of potential functional contribution. Notably, the relative abundance of the predominant family Enterobacteriaceae was significantly decreased on the third day post-parasitization. In addition, the results of traditional isolation and culture of bacteria indicated differences in the bacterial composition between the three DPP and CK3 groups, as with 16S microbial profiling. These findings shed light on the interaction between a parasitic wasp and gut bacteria in the host insect during parasitization.
Transfer of Copper (Cu) in the Soil–Plant–Mealybug–Ladybird Beetle Food Chain
Authors: Wang Xingmin , Zhang Mengting , Cao Huiyi , Dar Mudasir Irfan , Ali Shaukat
Published: August 2022

Copper, an essential trace element, is vital for living organisms’ survival; however, despite its importance, an excessive amount of this micro-nutrient can cause harmful effects to plants and animals. The present study investigates Cu bio-transfer across multi-trophic food chain comprising soil (spiked with various concentrations of Cu), eggplant (Solanum melongena), mealybug (Ferrisia virgata), and ladybird (Nephus ryuguus). Soils were spiked with Cu at rates of 0, 100, 200, 400, and 800 mg/kg (w/w). A dose-dependent increase in the levels of Cu in plant, mealybug, and ladybird was observed in response to Cu contents of soil. Different Cu amendment caused a significant reduction in the average root and shoot dry weights per plant as well as the average body weights of F. virgata and N. ryuguus. Our findings affirmed the importance of additional research to explain the processes involved in the bio-transfer of copper across the food chain.
Fall Armyworm Gut Bacterial Diversity Associated with Different Developmental Stages, Environmental Habitats, and Diets
Authors: Li Dan-Dan , Li Jin-Yang , Hu Zu-Qing , Liu Tong-Xian , Zhang Shi-Ze
Published: August 2022

The fall armyworm, Spodoptera frugiperda (Lepidoptera: Noctuidae), is a major invasive pest that seriously threatens world agricultural production and food security. Microorganisms play a crucial role in the growth and development of insects. However, the diversity and dynamics of gut microbes with different developmental stages, environmental habitats, and diets in S. frugiperda remain unclear. In this study, we found the changes of the microbiome of S. frugiperda across their life stages, and the bacteria were dominated by Firmicutes and Proteobacteria. The community composition of the egg stage was quite different from other developmental stages, which had the highest community diversity and community richness, and was dominated by Proteobacteria. The bacterial community compositions of male and female adults were similar to those of early larvae stage (L1–L2), and operational taxonomic units (OTUs) with abundant content were Enterococcus and Enterobacteriaceae bacteria, including Enterobacteria, Klebsiella, Pantoea, and Escherichia. The third instar larvae (L3) mainly consist of Enterococcus. The late stage larvae (L4–L6) harbored high proportions of Enterococcus, Rhodococcus, and Ralstonia. There was no significant difference in gut microbial composition between field populations and laboratory populations in a short period of rearing time. However, after long-term laboratory feeding, the gut microbial diversity of S. frugiperda was significantly reduced. Enterococcus and Rhodococccus of S. frugiperda feeding on maize showed higher relative proportion, while the microbial community of S. frugiperda feeding on artificial diet was composed mainly of Enterococcus, with a total of 98% of the gut microbiota. The gene functions such as metabolism, cell growth and death, transport and catabolism, and environmental adaptation were more active in S. frugiperda feeding on corn than those feeding on artificial diet. In short, these results indicate that developmental stage, habitat, and diet can alter the gut bacteria of S. frugiperda, and suggest a vertical transmission route of bacteria in S. frugiperda. A comprehensive understanding of gut microbiome of S. frugiperda will help develop novel pest control strategies to manage this pest.
Nutritional and Functional Properties of Defatted Flour, Protein Concentrates, and Isolates of Brachytrupes membranaceus (Orthoptera: Gryllidae) (Drury: 1773) and Macrotermes subhyalinus (Isoptera: Blattodea) (Rambur: 1842) from Burkina Faso
Authors: Séré Aminata , Bougma Adjima , Bazié Bazoin Sylvain Raoul , Nikièma Philippe Augustin , Gnankiné Olivier , Bassolé Imael Henri Nestor
Published: August 2022

Brachytrupes membranaceus and Macrotermes subhyalinus are edible insects in Burkina Faso. Our research aimed to evaluate the nutritional composition and functional properties of the defatted flours, protein concentrates, and isolates of Brachytrupes membranaceus and Macrotermes subhyalinus. Proximate and mineral composition were determined according to AOAC methods. The amino acid and fatty acid composition were determined by high-performance liquid chromatography (HPLC) and gas chromatography, respectively. The protein concentrates and isolates were obtained by solubilization, precipitation, and lyophilization. Macrotermes subhyalinus showed the highest protein (45.75 g/100 g), iron (11.76 mg/100 g), and zinc (13.18 mg/100 g) contents. The highest isoleucine and lysine contents, the best fat absorption (10.87 g/g), and foaming capacities (49.60%) were obtained with the isolate of Brachytrupes membranaceus. Consumption of Macrotermes subhyalinus could be used to fight or correct iron and zinc deficiencies. Macrotermes subhyalinus was a source of macronutrients and micronutrients, while the protein concentrates and isolates of Brachytrupes membranaceus were endowed with functional properties (fat absorption and foaming capacities).
Various Types of Virtual Reality-Based Therapy for Eating Disorders: A Systematic Review
Authors: Ciążyńska Julia , Maciaszek Janusz
Published: August 2022

(1) Background: Interactive VR (virtual reality) environments (i.e., using three-dimensional graphics presented with a head-mounted display) have recently become a popular professional tool for the treatment of patients with eating disorders (EDs). However, there are no published review reports that have analyzed the original papers between 2015 and 2021, which additionally focused only on HMD (head-mounted display) 3DVR (three-dimensional virtual reality) exposure and included only three therapeutic categories for ED patients. (2) Methods: The EbscoHost and Scopus databases were searched to identify relevant papers on VR research employing VR in the assessment and treatment of eating disorders. (3) Results: In addition to the known therapeutic divisions for ED, there are new forms of therapy based on 360 cameras, eye-tracking, and remote therapy. (4) Conclusions: The potential of VR in combination with different therapies may offer an alternative for future research. More rigorous testing, especially in terms of larger sample sizes, the inclusion of control groups or multisessions, and follow-up measures, is still needed. The current state of research highlights the importance of the nature and content of VR interventions for ED patients. Future research should look to incorporate more home-based and remote forms of VR tools.
Inodilators May Improve the In-Hospital Mortality of Patients with Cardiogenic Shock Undergoing Veno-Arterial Extracorporeal Membrane Oxygenation
Authors: Kim Mijoo , Seong Seok-Woo , Song Pil Sang , Jeong Jin-Ok , Yang Jeong Hoon , Gwon Hyeon-Cheol , Ko Young-Guk , Yu Cheol Woong , Chun Woo Jung , Jang Woo Jin , Kim Hyun-Joong , Bae Jang-Whan , Kwon Sung Uk , Lee Hyun-Jong , Lee Wang Soo , Park Sang-Don , Cho Sung Soo , Park Jae-Hyeong
Published: August 2022

Although inodilators (dobutamine and milrinone) are widely used empirically for cardiogenic shock (CS), the efficacy of inodilators for patients with CS undergoing veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is controversial. We evaluated the effects of inodilators on clinical outcomes using the RESCUE (REtrospective and prospective observational Study to investigate Clinical oUtcomes and Efficacy of left ventricular assist device for Korean patients with cardiogenic shock; NCT02985008) registry. We selected and analyzed the clinical outcomes of 496 patients who underwent VA-ECMO and did or did not receive inodilators. Of the 496 patients, 257 (51.8%) died during hospitalization. We selected 191 matched pairs to adjust for baseline clinical characteristics after 1:1 propensity score matching (PSM). The univariate and multivariate analyses showed that the inodilator group had significantly lower in-hospital mortality than the no-inodilator group (unadjusted hazard ratio [HR], 0.768; 95% confidence interval [CI], 0.579–1.018; p = 0.066, adjusted HR, 0.702; 95% CI, 0.552–0.944; p = 0.019). For patients with CS undergoing VA-ECMO, inodilators may improve clinical outcomes.
Temporal Trends of Transcatheter Aortic Valve Implantation over 12 Years: A High-Volume Single-Center Experience
Authors: Frydman Shir , Zahler David , Merdler Ilan , Freund Ophir , Shacham Yacov , Banai Shmuel , Finkelstein Ariel , Steinvil Arie
Published: August 2022

Transcatheter aortic valve replacement (TAVR) has become the mainstay of treatment for patients with severe AS. Since the TAVR population and patients’ outcomes have dramatically changed over the last decade, updated data regarding contemporary practice and trends are pertinent to clinical use. We performed a retrospective observational analysis of consecutive patient who underwent TAVR for symptomatic severe AS between the years 2009 and 2021 in a single high-volume center. Patients were divided into four equal time groups based on the procedure date (2009–2012, 2013–2015, 2016–2018 and 2019–2021). A total of 1988 patients were included in this study and divided into four groups, with 321, 482, 565 and 620 patients in groups 1–4, respectively. Significant trends were seen in baseline characteristics of a few parameters, including lower age, lower procedural risk and reduced rates of comorbidity (p for trend < 0.0001 for all factors mentioned above). A shift was seen in the procedural technique with lower balloon pre-dilatation and higher device success rates (p for trend < 0.0001). The post-procedural period changed over the years with fewer pacemaker placements (p < 0.0001) and reduced rates of AKI and post-procedural bleed (p value 0.02 and <0.0001, respectively). Furthermore, overall hospital stay was shortened from 7 ± 7.1 days to 2.3 ± 1.7 (p < 0.0001). Finally, patient follow up revealed reduced mortality rates at 30 days (p < 0.0001) and 1 year (p = 0.013). Multivariate regression revealed that a late implantation date was an independent protector from mortality (HR 0.84, p = 0.002). In conclusion, our study demonstrated that TAVR has become a safer practice over the years with reduced rates of morbidity and mortality.
Empiric Anticoagulation Therapy in Hospitalized COVID-19 Patients: An Evaluation of Bleeding Risk Scores Performances in Predicting Bleeding Events
Authors: Abdelrahman Mona A. , Ahmed Aya , Alanazi Abdullah S. , Osama Hasnaa
Published: August 2022

Currently, there is no standardized consensus on anticoagulation (AC) among patients with coronavirus disease (COVID-19), which has an overwhelming bleeding risk. We aimed to compare the patterns of AC in COVID-19 patients and compare two validated risk scores in predicting bleeding events. A retrospective review of medical records was conducted for COVID-19 patients who received empiric anticoagulation therapy. The primary outcomes included bleeding events, survival, and mechanical ventilation needs. We applied the HAS-BLED and ORBIT bleeding risk scores to assess the predictive accuracy, using c-statistics and the receiver operating curve (ROC) method. Of the included patients (n = 921), with a mean age of 58.1 ± 13.2, 51.6% received therapeutic AC and 48.4% received a prophylactic AC dose. Significantly higher values of d-dimer and C-reactive protein (CRP) among the therapeutic AC users (p < 0.001) were noted with a significantly prolonged duration of hospital stay and mechanical ventilation (p < 0.001 and p = 0.011, respectively). The mean value of the HAS-BLED and ORBIT scores were 2.53 ± 0.93 and 2.26 ± 1.29, respectively. The difference between the two tested scores for major bleeding and clinically relevant non-major bleeding was significant (p = 0.026 and 0.036, respectively) with modest bleeding predictive performances. The therapeutic AC was associated with an increased risk of bleeding. HAS-BLED showed greater accuracy than ORBIT in bleeding risk predictability.
Surgery for Ulcerative Colitis in the White British and South Asian Populations in Selected Trusts in England 2001–2020: An Absence of Disparate Care and a Need for Specialist Centres
Authors: Farrukh Affifa , Mayberry John Francis
Published: August 2022

Over the last decade, there has been extensive evidence that patients with inflammatory bowel disease from minority communities in the UK receive less than optimal care. In none of the studies has the role of surgery in the management of acute and severe ulcerative colitis been considered in any detail. A freedom of information (FOI) request was sent to 14 NHS Trusts in England, which serve significant South Asian populations. Details of the type of surgery patients from the South Asian and White British communities received between 2021 and 2020 were requested. Detailed responses were obtained from eight Trusts. Four hundred and ten White British patients underwent surgery for ulcerative colitis over this period at these eight Trusts, together with 67 South Asian patients. There was no statistically significant difference in the distribution across the types of surgery undergone by the two communities overall (χ2 = 1.3, ns) and the proportions who underwent an ileo-anal anastomosis with pouch (z = −1.2, ns). However, within individual trusts, at the University Hospital Southampton NHS Foundation Trust, a significantly greater proportion of South Asian patients had an ileo-anal anastomosis with pouch compared to White British patients. At Cambridge University Hospitals NHS Foundation Trust, all 72 patients who underwent surgery for ulcerative colitis were White British. This study has shown that, in general, for patients with a severe flare of ulcerative colitis where medical treatment has failed and surgery is warranted, the nature of the procedures offered is the same in the White British and South Asian communities. However, of concern is the number of units with low volume procedures. For most Trusts reported in this study, the overall number of Ileo-anal pouch anastomosis or anastomosis of ileum to anus procedures performed over a number of years was substantially below that required for a single surgeon to achieve competence. These findings reinforce the argument that inflammatory bowel disease surgery should be performed in a limited number of high-volume centres rather than across a wide range of hospitals so as to ensure procedures are carried out by surgeons with sufficient and on-going experience.
The Clinical Effects of Pixel CO2 Laser on Bladder Neck and Stress Urinary Incontinence
Authors: Long Cheng-Yu , Lee Jennifer Po-Ning , Loo Zi-Xi , Liu Yi-Yin , Yeh Chang-Lin , Feng Chien-Wei , Lin Kun-Ling
Published: August 2022

Background: Our study aims to assess Pixel CO2 laser efficacy for female stress urinary incontinence (SUI). Methods: In the study, 25 women with SUI were included and scheduled for vaginal Pixel CO2 Laser (FemiLift™, Alma Lasers, Israel) treatment. All subjects had a baseline and 6-month post-treatment assessment that included three-dimensional perineal ultrasound and validated questionnaires. Results: Data showed that monthly three-session vaginal Pixel CO2 Laser treatment significantly improved SUI symptoms, as evidenced by validated questionnaires, including UDI-6, IIQ-7, ICIQ, and vaginal laxity questionnaire (p < 0.05). The Pixel CO2 Laser efficacy in vaginal treatment was 20/25 (80%), and the perineal sonography showed that laser treatment significantly decreased bladder neck mobility and middle urethral area (during resting and straining). Permanent adverse events were not found. Conclusions: The results of our study suggested that for the treatment of mild to moderate SUI symptoms, Pixel CO2 Laser is effective and safe; however, more studies and a longer follow-up should be conducted to confirm its efficacy and durability.
The Roles of Exosomes upon Metallic Ions Stimulation in Bone Regeneration
Authors: Luo Xuwei , Xiao Dongqin , Zhang Chengdong , Wang Guanglin
Published: August 2022

Metallic ions have been widely investigated and incorporated into bone substitutes for bone regeneration owing to their superior capacity to induce angiogenesis and osteogenesis. Exosomes are key paracrine mediators that play a crucial role in cell-to-cell communication. However, the role of exosomes in metallic ion-induced bone formation and their underlying mechanisms remain unclear. Thus, this review systematically analyzes the effects of metallic ions and metallic ion-incorporated biomaterials on exosome secretion from mesenchymal stem cells (MSCs) and macrophages, as well as the effects of secreted exosomes on inflammation, angiogenesis, and osteogenesis. In addition, possible signaling pathways involved in metallic ion-mediated exosomes, followed by bone regeneration, are discussed. Despite limited investigation, metallic ions have been confirmed to regulate exosome production and function, affecting immune response, angiogenesis, and osteogenesis. Although the underlying mechanism is not yet clear, these insights enrich our understanding of the mechanisms of the metallic ion-induced microenvironment for bone regeneration, benefiting the design of metallic ion-incorporated implants.
Closed-Loop Temperature and Force Control of Additive Friction Stir Deposition
Authors: Merritt Glen R. , Williams Malcolm B. , Allison Paul G. , Jordon James B. , Rushing Timothy W. , Cousin Christian A.
Published: August 2022

Additive Friction Stir Deposition (AFSD) is a recent innovation in non-beam-based metal additive manufacturing that achieves layer-by-layer deposition while avoiding the solid-to-liquid phase transformation. AFSD presents numerous benefits over other forms of fusion-based additive manufacturing, such as high-strength mechanical bonding, joining of dissimilar alloys, and high deposition rates. To improve, automate, and ensure the quality, uniformity, and consistency of the AFSD process, it is necessary to control the temperature at the interaction zone and the force applied to the consumable feedstock during deposition. In this paper, real-time temperature and force feedback are achieved by embedding thermocouples into the nonconsumable machine tool-shoulder and estimating the applied force from the motor current of the linear actuator driving the feedstock. Subsequently, temperature and force controllers are developed for the AFSD process, ensuring that the temperature at the interaction zone and the force applied to the feedstock track desired command values. The temperature and force controllers were evaluated separately and together on setpoints and time-varying trajectories. For combined temperature and force control with setpoints selected at a temperature of 420 °C and a force of 2669 N, the average temperature and force tracking errors are 5.4 ± 6.5 °C (1.4 ± 1.6%) and 140.1 ± 213.5 N (5.2 ± 8.0%), respectively.
Wave-Current Impact on Shear Stress Patterns around 3D Shallow Bedforms
Authors: Hopkins Julia , de Schipper Matthieu , Wengrove Meagan , Castelle Bruno
Published: August 2022

Observations from wave basin experiments and wave-resolving numerical simulations demonstrate the effect of wave-current interaction on shear stress around a sandy mound. Observations from the wave basin show that the mound deformation rate and morphological patterns depend on the mixture of waves and currents in the incident flow conditions. A SWASH nonhydrostatic numerical model was used to expand the parameter space of wave-current conditions observed in the flume and characterize the response of the near-bed shear stress to the mound. The model was validated with observations from wave-alone, current-alone, and wave-current flume tests and then ran for a suite of numerical flow conditions which isolate the impact of the ratio of wave-current energy on the bed shear stress. Results show how the current-to-wave ratio impacts the spatial heterogeneity of shear stress across the mound, with the region of shear stress intensification around the mound and the location of the peak shear stress becoming asymmetric with more mixed wave-current flows. These results show the nonlinear response of shear stress patterns to combined wave-current flows and how these patterns may impact eventual sediment transport and mound evolution.
Structural Parametric Optimization of the VolturnUS-S Semi-Submersible Foundation for a 15 MW Floating Offshore Wind Turbine
Authors: Liu Shiqi , Chuang Zhenju , Wang Kai , Li Xin , Chang Xin , Hou Lixun
Published: August 2022

The full exploitation of offshore wind resources can essentially satisfy the massive energy demand. The realization and application of ultra-high-power offshore wind turbines are crucial to achieving full use of deep-sea wind energy and reducing the cost of wind power. For the VolturnUS-S semi-submersible floating foundation of a 15 megawatt (MW) offshore wind turbine, the effect of structural parameters on hydrodynamic performance was investigated by controlling the variables described in this paper. Accordingly, the floating foundation was optimized and coupled to the 15 MW offshore wind turbine. The dynamic performance of the integrated 15 MW offshore wind turbine was analyzed under different operating conditions, by applying the aero-hydro-servo-elastic coupled method. The results show that for a wave in a 0-degree direction, a 5% increase of column spacing will reduce the peak value of the pitch transfer function by 33.61%, and that a 5% decrease of the outer column diameter will further reduce the peak value by 26.27%. The standard deviation of the time-domain surge responses was reduced by 19.78% for the optimized offshore wind turbine, and the maximum value of the mooring line tension was reduced by 13.55% under normal operating conditions.
Artificial Seaweed Reefs That Support the Establishment of Submerged Aquatic Vegetation Beds and Facilitate Ocean Macroalgal Afforestation: A Review
Authors: Jung Somi , Chau Than Van , Kim Minju , Na Won-Bae
Published: August 2022

Macroalgae are invaluable constituents of marine forest environments and important sources of material for human needs. However, they are currently at risk of severe decline due to global warming and negative anthropogenic factors. Restoration efforts focus on beds where macroalgae previously existed, as well as the creation of new marine forests. Some artificial seaweed reefs (ASRs) have succeeded but others have failed; the contributions of ASRs to marine forest formation have been not fully determined. Here, we review ASRs, the benefits of macroalgal forests, threats to macroalgae, restoration, and marine forest formation to explore the current status of ASRs. The published literature indicates that ASRs have played critical roles in marine forest formation; notably, they support the establishment of submerged aquatic vegetation beds that allow ocean macroalgal afforestation. ASRs have evolved in terms of complexity and the materials used; they can sustainably mitigate marine deforestation. However, continuous reviews of ASR performance are essential, and performance improvements are always possible.
Using Boosted Machine Learning to Predict Suicidal Ideation by Socioeconomic Status among Adolescents
Authors: Park Hwanjin , Lee Kounseok
Published: August 2022

(1) Background: This study aimed to use machine learning techniques to identify risk factors for suicidal ideation among adolescents and understand the association between these risk factors and socioeconomic status (SES); (2) Methods: Data from 54,948 participants were analyzed. Risk factors were identified by dividing groups by suicidal ideation and 3 SES levels. The influence of risk factors was confirmed using the synthetic minority over-sampling technique and XGBoost; (3) Results: Adolescents with suicidal thoughts experienced more sadness, higher stress levels, less happiness, and higher anxiety than those without. In the high SES group, academic achievement was a major risk factor for suicidal ideation; in the low SES group, only emotional factors such as stress and anxiety significantly contributed to suicidal ideation; (4) Conclusions: SES plays an important role in the mental health of adolescents. Improvements in SES in adolescence may resolve their negative emotions and reduce the risk of suicide.
Clinicians’ Perceptions towards Precision Medicine Tools for Cardiovascular Disease Risk Stratification in South Africa
Authors: Kamp Michelle , Pain Oliver , May Andrew , Lewis Cathryn M. , Ramsay Michèle
Published: August 2022

Cardiovascular diseases (CVDs) are a leading cause of mortality and morbidity in South Africa. Risk stratification is the preferred approach to disease prevention, but identifying patients at high risk for CVD remains challenging. Assessing genetic risk could improve stratification and inform a clinically relevant precision medicine (PM) approach. Clinicians are critical to PM adoption, thus, this study explores practicing clinicians’ perceptions of PM-based CVD risk stratification in South Africa’s public health setting. Practicing clinicians (n = 109) at four teaching hospitals in Johannesburg, South Africa, completed an electronic self-administered survey. The effect of demographic and professional characteristics on PM-based CVD risk stratification perceptions was assessed. Fewer than 25% of respondents used clinical genetic testing, and 14% had formal genetics training. 78% had a low mean knowledge score, with higher scores associated with genetic training (p < 0.0005) and research involvement (p < 0.05). Despite limited knowledge and resources, 84% perceived PM approaches positively. 57% felt confident in applying the PM-based approach, with those already undertaking CVD risk stratification more confident (p < 0.001). High cost and limited access to genetics services are key barriers. Integrating genetic information into established clinical tools will likely increase confidence in using PM approaches. Addressing the genetics training gap and investment into the country’s genomics capacity is needed to advance PM in South Africa.
Clinical and Novel Biomarkers in Penile Carcinoma: A Prospective Review
Authors: Pekarek Leonel , Ortega Miguel A. , Fraile-Martinez Oscar , García-Montero Cielo , Casanova Carlos , Saez Miguel A. , García-Honduvilla Natalio , Alvarez-Mon Melchor , Buján Julia , Diez-Nicolas Victor , Burgos Javier F. , Gomez Dos Santos Victoria
Published: August 2022

Penile carcinoma is a rare urological neoplasia in men compared to other more common tumors, such as prostate, kidney, or bladder tumors. However, this neoplasm continues to affect a large number of patients worldwide, with developing countries presenting the highest incidence and mortality rates. Important risk factors such as the human papilloma virus, a factor affecting a large number of patients, have been described; however, few studies have evaluated screening programs in populations at risk for this disease, which severely affects the quality of life of older men. The management of these patients is usually complex, requiring surgical interventions that are not without risk and that have a great impact on the functionality of the male reproductive system. In addition, in cases of disseminated disease or with significant locoregional involvement, patients are evaluated by multidisciplinary oncological committees that can adjust the application of aggressive neoadjuvant or adjuvant chemotherapy on numerous occasions without clear improvement in survival. Chemotherapy regimens are usually aggressive, and unlike in other urological neoplasms, few advances have been made in the use of immunotherapy in these patients. The study of serological and histological biomarkers may help to better understand the underlying pathophysiology of these tumors and select patients who have a higher risk of metastatic progression. Similarly, the analysis of molecular markers will improve the availability of targeted therapies for the management of patients with disseminated disease that would benefit prognosis. Therefore, the purpose of this article is to summarize the main advances that have occurred in the development of serological and histological markers and their therapeutic implications in patients diagnosed with penile carcinoma, explaining the limitations that have been observed and analyzing future perspectives in the management of this disease.
Determining the Individual Theta Frequency for Associative Memory Targeted Personalized Transcranial Brain Stimulation
Authors: Bjekić Jovana , Paunovic Dunja , Živanović Marko , Stanković Marija , Griskova-Bulanova Inga , Filipović Saša R.
Published: August 2022

Non-invasive brain stimulation (NIBS) methods have gained increased interest in research and therapy of associative memory (AM) and its impairments. However, the one-size-fits-all approach yields inconsistent findings, thus putting forward the need for electroencephalography (EEG)-guided personalized frequency-modulated NIBS protocols to increase the focality and the effectiveness of the interventions. Still, extraction of individual frequency, especially in the theta band, turned out to be a challenging task. Here we present an approach to extracting the individual theta-band frequency (ITF) from EEG signals recorded during the AM task. The method showed a 93% success rate, good reliability, and the full range of variability of the extracted ITFs. This paper provides a rationale behind the adopted approach and critically evaluates it in comparison to the alternative methods that have been reported in the literature. Finally, we discuss how it could be used as an input parameter for personalized frequency-modulated NIBS approaches—transcranial alternating current stimulation (tACS) and transcranial oscillatory current stimulation (otDCS) directed at AM neuromodulation.
The Financial Determinants of Integrated Reporting Disclosure by Jordanian Companies
Authors: Al Amosh Hamzeh , Khatib Saleh F. A. , Hussainey Khaled
Published: August 2022

The paper aims to investigate the effect of financial leverage, profitability, liquidity ratios, cash holdings, and interest coverage ratios on the level of integrated reporting disclosure—as one of the reports that promotes sustainable development—of Jordanian industrial listed companies. The content analysis method was used to analyze the annual reports of 51 listed Jordanian industrial companies during the years from 2014 to 2019 (306 firm-year observations). The analysis showed that financial leverage, profitability, liquidity and cash holdings are important determinants for integrated reporting, whereas the analysis did not support the effect of the interest coverage ratio. To the best of our knowledge, this is the first empirical study that deals with the impact of a set of financial variables on integrated reporting in the context of emerging countries such as Jordan. This is also the first study that deals with disclosing integrated reports through the perspective of shareholders and stakeholders, as integrated reporting contains two parts, financial and non-financial; therefore, the current study contributes to the disclosure literature by providing new theoretical and empirical evidence in the context of emerging markets.
A Model for Iberian Wolf (Canis lupus signatus, Cabrera 1907) Predation Risk Assessment on Cattle in the Central System (Spain)
Authors: Velázquez Javier , Dios Andoni , Gülçin Derya , Özcan Ali , Hernando Ana , Santamaría Tomás , Salas-López Alex
Published: August 2022

As a consequence of the exponential increase of the demographic and technological development of the human being, conflicts with the natural environment are accentuated. Pollution or the loss of biodiversity represent examples of problems that we must face to maintain the balance between the evolution of human beings and the conservation of nature. However, there are conflicts whose origin is not as modern as those mentioned, and we return to the Neolithic to find the origin of the conflict of man with the great predators. This condition has existed since then and at this point in history, is reaching very high levels of tension in developed countries, as a result of the depredation of livestock. Wolf is one of the species that generates more conflict and is currently suffering a slight demographic expansion. Although current laws mostly seek their recovery and conservation, the wolf is experiencing great difficulties due to the poor social perception it has. Faced with this situation, a model has been developed using geographic information systems which categorizes the areas according to their probability that the cattle could suffer a wolf attack. Based on natural and anthropogenic variables of the environment, the areas with a greater or lesser probability of attack were evaluated, with the objective of designing a prevention plan to reduce or eliminate the attacks. Since different authors demonstrate that population control measures on the species are not effective in reducing attacks on livestock, the solution to the conflict should be based on preventive measures. The use of the designed model will enable the competent authorities to apply these measures optimally, reducing expenses and allowing to anticipate future areas of conflict.
Effect of Housing Support Programs on Residential Satisfaction and the Housing Cost Burden: Analysis of the Effect of Housing Support Programs in Korea Based on Household Attributes
Authors: Kim Saehim , Hwang Joonwon , Lee Myeong-Hun
Published: August 2022

Korea is implementing housing support programs such as public rental housing and housing allowances to improve the housing welfare of low-income households. In this study, we empirically analyzed the effects of the public rental housing program and the housing allowance program on residential satisfaction and the housing cost burden of policy beneficiaries. In accordance with household attributes, we analyzed how the status of using these programs affected each group’s residential satisfaction and housing cost burden. We used the data from the 2020 Korea Housing Survey conducted by the Ministry of Land, Infrastructure and Transport. We examined the housing support programs’ effects on each of the following household groups: all households, one-person households, households of newlywed couples, young adult households, and households of the elderly. The status of residing in public rental housing positively affected the residential satisfaction among all households, one-person households, and households of the elderly. It reduced the housing cost burden for all household types. The status of receiving the housing allowance negatively affected the residential satisfaction for all households and increased the housing cost burden for young adult households. We present policy implications for future housing support programs based on the findings.
Colchicine versus Physical Therapy in Knee Osteoarthritis
Authors: Cioroianu George Ovidiu , Florescu Alesandra , Mușetescu Anca Emanuela , Sas Teodor Nicușor , Rogoveanu Otilia Constantina
Published: August 2022

Background: The treatment of osteoarthritis remains a major challenge due to the unavailability of a disease-modifying medication and the limitations of current therapeutic perspectives, which mainly target the symptoms, not the disease itself. The purpose of our study is to compare the efficacy of colchicine treatment versus physical therapy. Methods: The study included 62 patients diagnosed with knee osteoarthritis (KOA) according to the American College of Rheumatology (ACR) criteria, hospitalized within the time frame of October 2020–March 2022 in the Department of Rehabilitation Medicine and Physical Therapy of the Emergency Clinical County Hospital of Craiova. The participants were randomly divided into two groups. The observation period was 16 weeks long. The first group (31 patients) received colchicine at a dosage of 1 mg/day together with analgesics (acetaminophen < 2 g/day), while the second group (31 patients) received analgesics (acetaminophen < 2 g/day) together with a 16-week plan of physiotherapy. Results: Group II, in which patients underwent physical therapy, demonstrated a statistically significant decrease in both left (p < 0.001) and right (p = 0.012) knee VAS and WOMAC (p = 0.038) scores at 16 weeks, compared to the group treated with colchicine. Regarding the MSUS examination at 16 weeks, there were no significant changes in the structural abnormalities and no improvement in cartilage aspect or thickness. Higher BMI was associated with higher WOMAC score (p = 0.012), but not with higher VAS score (p = 0.062). Cholesterol and triglyceride levels were associated with high WOMAC (p < 0.001; p = 0.021) and high VAS (p = 0.023; p < 0.001) scores. Conclusions: Our study monitored VAS and WOMAC scores in two groups of patients with KOA, showing that physical therapy is more effective than colchicine in reducing symptoms. We found no statistically significant difference in musculoskeletal ultrasound (MSUS) feature improvement during the 16-week study.
A Holistic View of Advanced Heart Failure
Authors: Triposkiadis Filippos , Giamouzis Grigorios , Kitai Takeshi , Skoularigis John , Starling Randall , Xanthopoulos Andrew
Published: August 2022

Advanced heart failure (HF) may occur at any level of left ventricular (LV) ejection fraction (LVEF). The latter, which is widely utilized for the evaluation of LV systolic performance and treatment guidance of HF patients, is heavily influenced by LV size and geometry. As the accurate evaluation of ventricular systolic function and size is crucial in patients with advanced HF, the LVEF should be supplemented or even replaced by more specific indices of LV function such as the systolic strain and cardiac power output and size such as the LV diastolic diameters and volumes. Conventional treatment (cause eradication, medications, devices) is often poorly tolerated and fails and advanced treatment (mechanical circulatory support [MCS], heart transplantation [HTx]) is required. The effectiveness of MCS is heavily dependent on heart size, whereas HTx which is effective in the vast majority of the cases is limited by the small donor pool. Expanding the MCS indications to include patients with small ventricles as well as the HTx donor pool are major challenges in the management of advanced HF.
[N,N′-Di-tert-butyl-P,P-diphenylphosphinimidic Amidato-κN,κN′]chlorosilicon-κSi-tetracarbonyliron
Authors: Takahashi Shintaro , Nakaya Kazuki , Ishii Akihiko , Nakata Norio
Published: August 2022

The title complex {[Ph2P(tBuN)2](Cl)Si:->Fe(CO)4} (2) was synthesized via the reaction of chlorosilylene [Ph2P(tBuN)2]SiCl (1), supported by an iminophosphonamide ligand with Fe(CO)5 in THF. The molecular structure of 2 was fully characterized by NMR (1H, 13C, 29Si, and 31P) and IR spectroscopies, as well as single-crystal X-ray diffraction (SCXRD) analysis. In the SCXRD analysis of 2, the silylene ligand was located in the axial positions of the coordination sphere of the central iron atom and other sites were occupied by carbonyl ligands.
SEIARN: Intelligent Early Warning Model of Epidemic Spread Based on LSTM Trajectory Prediction
Authors: Wang Liya , Dai Yaxun , Wang Renzhuo , Sun Yuwen , Zhang Chunying , Yang Zhiwei , Sun Yuqing
Published: August 2022

A SEIARN compartment model with the asymptomatic infection and secondary infection is proposed to predict the trend of COVID-19 more accurately. The model is extended according to the propagation characteristics of the novel coronavirus, the concepts of the asymptomatic infected compartment and secondary infection are introduced, and the contact rate parameters of the improved model are updated in real time by using the LSTM trajectory, in order to make accurate predictions. This SEIARN model first builds on the traditional SEIR compartment model, taking into account the asymptomatic infection compartment and secondary infection. Secondly, it considers the disorder of the trajectory and uses the improved LSTM model to predict the future trajectory of the current patients and cross-track with the susceptible patients to obtain the contact rate. Then, we conduct real-time updating of exposure rates in the SEIARN model and simulation of epidemic trends in Tianjin, Xi’an, and Shijiazhuang. Finally, the comparison experiments show that the SEIARN model performs better in prediction accuracy, MSE, and RMSE.
Two Inverse Eigenproblems for Certain Symmetric and Nonsymmetric Pentadiagonal Matrices
Authors: Arela-Pérez S. , Lozano Charlie , Nina Hans , Pickmann-Soto H.
Published: August 2022

In this paper, we give sufficient conditions for the construction of certain symmetric and nonsymmetric pentadiagonal matrices from particular spectral information. The construction of the symmetric pentadiagonal matrix considers the extreme eigenvalues of its leading principal submatrices and a prescribed entry, and the construction of the nonsymmetric pentadiagonal matrix also considers an eigenvector and two prescribed entries.