bluuebunny/crossref_metadata_2025 huggingface dataset:
Schematherapie
Authors: Jacob Gitta , Seebauer Laura
Published: February 2015

Schematherapie ist ein integrativer psychotherapeutischer Ansatz insbesondere zur Behandlung von Persönlichkeitsstörungen (PS) und Patienten mit chronischen und komplexen psychischen Störungen. Er kombiniert Konzepte der Verhaltenstherapie, der Tiefenpsychologie sowie humanistischer Ansätze, insb. der Gestalttherapie. Ein Schwerpunkt der Arbeit liegt auf emotionsfokussierten Techniken. Neben einem allgemeinen störungsübergreifenden Konzept wurden störungsspezifische Modelle für verschiedene PS entwickelt. Mehrere randomisiert-kontrollierte Studien wurden bisher bei Patienten mit Borderline-PS durchgeführt. Eine große randomisiert-kontrollierte Studie wurde zudem bei Patienten mit verschiedenen anderen PS abgeschlossen, eine weitere große Studie läuft bei forensischen Patienten. Alle bisherigen Studien zeigen eine gute Wirksamkeit, wobei eine ausreichende Dauer der Behandlung ausschlaggebend zu sein scheint. Forschung zu den schematherapeutischen Konstrukten weist auf eine gute Validität hin, allerdings auch auf eine hohe Überlappung mit anderen Maßen für Psychopathologie. Die aktuell zu beobachtende Ausweitung auf eine Vielzahl von Achse I-Störungen wird kritisch diskutiert.
The Contribution of Arterial Blood Gases in Cerebral Blood Flow Regulation and Fuel Utilization in Man at High Altitude
Authors: Willie Christopher K , MacLeod David B , Smith Kurt J , Lewis Nia C , Foster Glen E , Ikeda Keita , Hoiland Ryan L , Ainslie Philip N
Published: February 2015

The effects of partial acclimatization to high altitude (HA; 5,050 m) on cerebral metabolism and cerebrovascular function have not been characterized. We hypothesized (1) increased cerebrovascular reactivity (CVR) at HA; and (2) that CO2 would affect cerebral metabolism more than hypoxia. PaO2 and PaCO2 were manipulated at sea level (SL) to simulate HA exposure, and at HA, SL blood gases were simulated; CVR was assessed at both altitudes. Arterial–jugular venous differences were measured to calculate cerebral metabolic rates and cerebral blood flow (CBF). We observed that (1) partial acclimatization yields a steeper CO2-H+ relation in both arterial and jugular venous blood; yet (2) CVR did not change, despite (3) mean arterial pressure (MAP)-CO2 reactivity being doubled at HA, thus indicating effective cerebral autoregulation. (4) At SL hypoxia increased CBF, and restoration of oxygen at HA reduced CBF, but neither had any effect on cerebral metabolism. Acclimatization resets the cerebrovasculature to chronic hypocapnia.
CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production
Authors: Khairnar Vishal , Duhan Vikas , Maney Sathish Kumar , Honke Nadine , Shaabani Namir , Pandyra Aleksandra A. , Seifert Marc , Pozdeev Vitaly , Xu Haifeng C. , Sharma Piyush , Baldin Fabian , Marquardsen Florian , Merches Katja , Lang Elisabeth , Kirschning Carsten , Westendorf Astrid M. , Häussinger Dieter , Lang Florian , Dittmer Ulf , Küppers Ralf , Recher Mike , Hardt Cornelia , Scheffrahn Inka , Beauchemin Nicole , Göthert Joachim R. , Singer Bernhard B. , Lang Philipp A. , Lang Karl S.
Published: February 2015

B cells are essential for antiviral immune defence because they produce neutralizing antibodies, present antigen and maintain the lymphoid architecture. Here we show that intrinsic signalling of CEACAM1 is essential for generating efficient B-cell responses. Although CEACAM1 exerts limited influence on the proliferation of B cells, expression of CEACAM1 induces survival of proliferating B cells via the BTK/Syk/NF-κB-axis. The absence of this signalling cascade in naive Ceacam1−/− mice limits the survival of B cells. During systemic infection with cytopathic vesicular stomatitis virus, Ceacam1−/− mice can barely induce neutralizing antibody responses and die early after infection. We find, therefore, that CEACAM1 is a crucial regulator of B-cell survival, influencing B-cell numbers and protective antiviral antibody responses.
RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL
Authors: Lawlor Kate E. , Khan Nufail , Mildenhall Alison , Gerlic Motti , Croker Ben A. , D’Cruz Akshay A. , Hall Cathrine , Kaur Spall Sukhdeep , Anderton Holly , Masters Seth L. , Rashidi Maryam , Wicks Ian P. , Alexander Warren S. , Mitsuuchi Yasuhiro , Benetatos Christopher A. , Condon Stephen M. , Wong W. Wei-Lynn , Silke John , Vaux David L. , Vince James E.
Published: February 2015

RIPK3 and its substrate MLKL are essential for necroptosis, a lytic cell death proposed to cause inflammation via the release of intracellular molecules. Whether and how RIPK3 might drive inflammation in a manner independent of MLKL and cell lysis remains unclear. Here we show that following LPS treatment, or LPS-induced necroptosis, the TLR adaptor protein TRIF and inhibitor of apoptosis proteins (IAPs: X-linked IAP, cellular IAP1 and IAP2) regulate RIPK3 and MLKL ubiquitylation. Hence, when IAPs are absent, LPS triggers RIPK3 to activate caspase-8, promoting apoptosis and NLRP3–caspase-1 activation, independent of RIPK3 kinase activity and MLKL. In contrast, in the absence of both IAPs and caspase-8, RIPK3 kinase activity and MLKL are essential for TLR-induced NLRP3 activation. Consistent with in vitro experiments, interleukin-1 (IL-1)-dependent autoantibody-mediated arthritis is exacerbated in mice lacking IAPs, and is reduced by deletion of RIPK3, but not MLKL. Therefore RIPK3 can promote NLRP3 inflammasome and IL-1β inflammatory responses independent of MLKL and necroptotic cell death.
Dendritic geometry shapes neuronal cAMP signalling to the nucleus
Authors: Li Lu , Gervasi Nicolas , Girault Jean-Antoine
Published: February 2015

Neurons have complex dendritic trees, receiving numerous inputs at various distances from the cell body. Yet the rules of molecular signal propagation from dendrites to nuclei are unknown. DARPP-32 is a phosphorylation-regulated signalling hub in striatal output neurons. We combine diffusion-reaction modelling and live imaging to investigate cAMP-activated DARPP-32 signalling to the nucleus. The model predicts maximal effects on the nucleus of cAMP production in secondary dendrites, due to segmental decrease of dendrite diameter. Variations in branching, perikaryon size or spines have less pronounced effects. Biosensor kinase activity measurement following cAMP or dopamine uncaging confirms these predictions. Histone 3 phosphorylation, regulated by this pathway, is best stimulated by cAMP released in secondary-like dendrites. Thus, unexpectedly, the efficacy of diffusion-based signalling from dendrites to nucleus is not inversely proportional to the distance. We suggest a general mechanism by which dendritic geometry counterbalances the effect of dendritic distance for signalling to the nucleus.
Intermediate DNA methylation is a conserved signature of genome regulation
Authors: Elliott GiNell , Hong Chibo , Xing Xiaoyun , Zhou Xin , Li Daofeng , Coarfa Cristian , Bell Robert J.A. , Maire Cecile L. , Ligon Keith L. , Sigaroudinia Mahvash , Gascard Philippe , Tlsty Thea D. , Harris R. Alan , Schalkwyk Leonard C. , Bilenky Misha , Mill Jonathan , Farnham Peggy J. , Kellis Manolis , Marra Marco A. , Milosavljevic Aleksandar , Hirst Martin , Stormo Gary D. , Wang Ting , Costello Joseph F.
Published: February 2015

The role of intermediate methylation states in DNA is unclear. Here, to comprehensively identify regions of intermediate methylation and their quantitative relationship with gene activity, we apply integrative and comparative epigenomics to 25 human primary cell and tissue samples. We report 18,452 intermediate methylation regions located near 36% of genes and enriched at enhancers, exons and DNase I hypersensitivity sites. Intermediate methylation regions average 57% methylation, are predominantly allele-independent and are conserved across individuals and between mouse and human, suggesting a conserved function. These regions have an intermediate level of active chromatin marks and their associated genes have intermediate transcriptional activity. Exonic intermediate methylation correlates with exon inclusion at a level between that of fully methylated and unmethylated exons, highlighting gene context-dependent functions. We conclude that intermediate DNA methylation is a conserved signature of gene regulation and exon usage.
Sequence-selective DNA binding with cell-permeable oligoguanidinium–peptide conjugates
Authors: Mosquera Jesús , Sánchez Mateo I. , Valero Julián , Mendoza Javier de , Vázquez M. Eugenio , Mascareñas José L.
Published: February 2015

Conjugation of a short peptide fragment from a bZIP protein to an oligoguanidinium tail results in a DNA-binding miniprotein that selectively interacts with composite sequences containing the peptide-binding site next to an A/T-rich tract.
Consistent prediction of streaming potential in non-Newtonian fluids: the effect of solvent rheology and confinement on ionic conductivity
Authors: Bandopadhyay Aditya , Chakraborty Suman
Published: February 2015

A consistent framework is developed to account for the solvent rheology and steric factor to obtain concentration-dependent ionic conductivity and streaming potential.
Synthesis, X-ray structure and in vitro cytotoxicity studies of Cu(i/ii) complexes of thiosemicarbazone: special emphasis on their interactions with DNA
Authors: Saswati Saswati , Chakraborty Ayon , Dash Subhashree P. , Panda Alok K. , Acharyya Rama , Biswas Ashis , Mukhopadhyay Subhadip , Bhutia Sujit K. , Crochet Aurélien , Patil Yogesh P. , Nethaji M. , Dinda Rupam
Published: February 2015

The interactions of four Cu-TSC complexes with DNA & their cytotoxicity studies against the HeLa cell have been reported.
A panchromatic hybrid crystal of iodoplumbate nanowires and J-aggregated naphthalene diimides with long-lived charge-separated states
Authors: Liu Jian-Jun , Guan Ying-Fang , Jiao Chen , Lin Mei-Jin , Huang Chang-Cang , Dai Wen-Xin
Published: February 2015

A panchromatic hybrid crystal of anionic iodoplumbate nanowires and J-aggregated protonated naphthalene diimides has been formed through charge-assisted anion–π and lone pair–π interactions.
GREEN MOTION: a new and easy to use green chemistry metric from laboratories to industry
Authors: Phan T. V. Tony , Gallardo Cyril , Mane Jean
Published: February 2015

GREEN MOTION™ by MANE is a novel approach for designing a new green metric that enables the measurement of the overall safety of a product, its impact on the environment and on the health of the people producing or using it.
Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling
Authors: Abaci Hasan Erbil , Shuler Michael L.
Published: February 2015

Advances in maintaining multiple human tissues on microfluidic platforms has led to a growing interest in the development of microphysiological systems for drug development studies.
Novel synthesis of thick wall coatings of titania supported Bi poisoned Pd catalysts and application in selective hydrogenation of acetylene alcohols in capillary microreactors
Authors: Cherkasov Nikolay , Ibhadon Alex O. , Rebrov Evgeny V.
Published: February 2015

A novel synthesis method for thick coatings inside long capillary reactors was reported and applied to the semihydrogenation of 2-methyl-3-butyn-2-ol.
Natural products mediating ecological interactions in Antarctic benthic communities: a mini-review of the known molecules
Authors: Núñez-Pons L. , Avila C.
Published: February 2015

The extreme, unique seas surrounding Antarctica harbor unusual communities where interactions are highly mediated by chemistry. This mini-review compiles the identified marine natural products proven to have an ecological role in Antarctic ecosystems.
Histidine-rich stabilized polyplexes for cMet-directed tumor-targeted gene transfer
Authors: Kos Petra , Lächelt Ulrich , Herrmann Annika , Mickler Frauke Martina , Döblinger Markus , He Dongsheng , Krhač Levačić Ana , Morys Stephan , Bräuchle Christoph , Wagner Ernst
Published: February 2015

The first report of tumor-targeted non-viral gene delivery exploiting c-Met as the cell surface receptor by using improved stabilized and histidines-enriched oligo(ethanamino)amides.
Removal of NO with silicene: a DFT investigation
Authors: Xu Xianyan , Li Jing , Zhang Xuepeng , Xu Huiying , Ke Zhuo-Feng , Zhao Cunyuan
Published: February 2015

NO can be adsorbed onto silicene and then reduced into N2via a dimer mechanism.
All carbon nanotube based flexible field emission devices prepared through a film transfer method
Authors: Xu Jinzhuo , Xu Peng , Guo Pingsheng , Ou-Yang Wei , Chen Yiwei , Feng Tao , Piao Xianqing , Wang Miao , Sun Zhuo
Published: February 2015

All carbon nanotube based field emission devices were prepared through a vacuum filtering/dry transferring method and the field emission properties of bent devices were systematically studied.
Wide bandgap materials design toward tunable bandgap and increased carries injection property: silane interrupting π-conjugation together with peripheralcarbazolyl substituents
Authors: Hu Dehua , Liu He , Lu Ping , Shen Fangzhong , Lv Ying , Ma Yuguang
Published: February 2015

Universal host for blue, green and red phosphorescent dopants is achieved by rational molecule design with silane interrupting π-conjugation and non-conjugated peripheralcarbazolyl substituents.
Photophysics of tungsten–benzylidyne complexes derived from s-indacene: synthesis, characterization and DFT studies
Authors: Morales-Verdejo Cesar A. , Zarate Ximena , Schott Eduardo , Correa Sebastián , Martinez-Díaz Iván
Published: February 2015

The photophysics of the mono- and homobimetallic complexes of tungsten benzylidyne has been examined by using absorption and emission. Theoretical calculations were carried out to gain further understanding of these novel molecular systems.
Computational study of the mechanism and selectivity of ruthenium-catalyzed hydroamidations of terminal alkynes
Authors: Maity Bholanath , Gooßen Lukas J. , Koley Debasis
Published: February 2015

Density functional theory calculations were performed to elucidate the mechanism of the ruthenium-catalyzed hydroamidation of terminal alkynes, a powerful and sustainable method for the stereoselective synthesis of enamides.
Self-assembled trinuclear arsenic and antimony macrobicycles
Authors: Collins Mary S. , Choi Robert Y. , Zakharov Lev N. , Watson Lori A. , Hay Benjamin P. , Johnson Darren W.
Published: February 2015

Six new macrobicyclic Pn3L2Cl3 complexes (Pn = As, Sb) were synthesized by self-assembly of a three-fold symmetric trithiol and PnCl3.
Magnetic cobalt–graphene nanocomposite derived from self-assembly of MOFs with graphene oxide as an activator for peroxymonosulfate
Authors: Andrew Lin Kun-Yi , Hsu Fu-Kong , Lee Wei-Der
Published: February 2015

While metal organic frameworks (MOFs) have been extensively explored as a platform for developing porous metal oxides, another intriguing direction is to use MOFs as precursors to prepare carbonaceous materials.
Effects of one- and two-dimensional carbon hybridization of PEDOT:PSS on the power factor of polymer thermoelectric energy conversion devices
Authors: Yoo Dohyuk , Kim Jeonghun , Lee Seung Hwan , Cho Wonseok , Choi Hyang Hee , Kim Felix Sunjoo , Kim Jung Hyun
Published: February 2015

Synergic effects of conducting polymers, carbon nanotubes, and graphene result in the enhanced thermoelectric properties of nanocomposites.
Periodically tailored titania nanotubes for enhanced drug loading and releasing performances
Authors: Gulati Karan , Kant Krishna , Findlay David , Losic Dusan
Published: February 2015

Structural engineering of titania nanotubes (TNTs) with periodically shaped structures was successfully demonstrated as a strategy to improve drug loading and releasing performances of TNTs/Ti implants.
Encapsulated enzymes with integrated fluorescence-control of enzymatic activity
Authors: Harimech Pascal K. , Hartmann Raimo , Rejman Joanna , del Pino Pablo , Rivera-Gil Pilar , Parak Wolfgang J.
Published: February 2015

Capsules filled with enzymes and fluorescence probes allow in situ enzymatic activity as well as kinetics on a single particle level to be monitored.
Luminescent network film deposited electrochemically from a carbazole functionalized AIE molecule and its application for OLEDs
Authors: Liu Cong , Luo Haiyuan , Shi Guang , Yang Jiajian , Chi Zhenguo , Ma Yuguang
Published: February 2015

A carbazole functionalized AIE molecule was constructed and applied as a precursor to prepare luminescent network films by electrochemical polymerization for efficient organic light-emitting devices (OLEDs).
Synthesis of orotidine by intramolecular nucleosidation
Authors: Kim E.-K. , Krishnamurthy R.
Published: February 2015

An intramolecular nucleosidation approach, using orotate as a leaving group, provides easy access to orotidine in high yields.
Direct introduction of a naphthalene-1,8-diamino boryl [B(dan)] group by a Pd-catalysed selective boryl transfer reaction
Authors: Xu Liang , Li Pengfei
Published: February 2015

Under Palladium-catalysed Miyaura-type reaction conditions, a non-symmetrical diboron reagent, B(pin)-B(dan), was found to selectively deliver the B(dan) moiety to aryl bromides and chlorides. This method represents a direct and efficient way to masked boronic acids and boron-differentiated di- and polyboron compounds.
Sensitive fluorescence detection of lysozyme using a tris(bipyridine)ruthenium(ii) complex containing multiple cyclodextrins
Authors: Zhang Fan , Zhao Ying-Ying , Chen Hong , Wang Xiu-Hua , Chen Qiong , He Pin-Gang
Published: February 2015

A new series of metallocyclodextrins with increased fluorescence intensity upon binding with ssDNAs/aptamers has been demonstrated to sensitively detect lysozyme.
Dynamic combinatorial chemistry on a monolayer protected gold nanoparticle
Authors: Maiti Subhabrata , Prins Leonard J.
Published: February 2015

The surface of a dynamic system spontaneously adapts to the added metal ion.
Heterogeneous double-activation catalysis: Rh complex and tertiary amine on the same solid surface for the 1,4-addition reaction of aryl- and alkylboronic acids
Authors: Noda Hiroto , Motokura Ken , Chun Wang-Jae , Miyaji Akimitsu , Yamaguchi Sho , Baba Toshihide
Published: February 2015

Double-activation catalysis by a rhodium complex/tertiary amine catalyst for the 1,4-addition of organoboronic acids was investigated.
O,N,N-Pincer ligand effects on oxidatively induced carbon–chlorine coupling reactions at palladium
Authors: Wright Luka A. , Hope Eric G. , Solan Gregory A. , Cross Warren B. , Singh Kuldip
Published: February 2015

The structural properties of a series of ONN-Pd(ii) chloride pincer complexes have been shown to influence the conversion to 4-chlorotoluene upon oxidation with di-p-tolyliodonium triflate.
One-step extraction and concentration of estrogens for an adequate monitoring of wastewater using ionic-liquid-based aqueous biphasic systems
Authors: Dinis Teresa B. V. , Passos Helena , Lima Diana L. D. , Esteves Valdemar I. , Coutinho João A. P. , Freire Mara G.
Published: February 2015

Aqueous biphasic systems composed of ionic liquids allow a single-step extraction–concentration of ethinylestradiol (EE2) from wastewater up to a 1000-fold.
Adsorption of ciprofloxacin onto graphene–soy protein biocomposites
Authors: Zhuang Yuan , Yu Fei , Ma Jie , Chen Junhong
Published: February 2015

New biocomposite, porous graphene–soy protein (GS) aerogels were prepared by a simple hydrothermal method and the mechanism of ciprofloxacin adsorption onto them was investigated.
A simple method to adjust the morphology of gradient three-dimensional PTB7-Th:PC71BM polymer solar cells
Authors: Zhao Ling , Zhao Suling , Xu Zheng , Yang Qianqian , Huang Di , Xu Xurong
Published: February 2015

Multiple interfaces are necessary for exciton separation in bulk heterojunction (BHJ) solar cells and continuous pathways for carrier transportation in donor : acceptor blend films, especially along the vertical direction, for efficient charge collection.
Self-powered electrospinning apparatus based on a hand-operated Wimshurst generator
Authors: Han Wen-Peng , Huang Yuan-Yuan , Yu Miao , Zhang Jun-Cheng , Yan Xu , Yu Gui-Feng , Zhang Hong-Di , Yan Shi-Ying , Long Yun-Ze
Published: February 2015

Self-powered electrospinning apparatus based on a hand-operated Wimshurst generator.
Fabrication of a white electroluminescent device based on bilayered yellow and blue quantum dots
Authors: Kim Jong-Hoon , Lee Ki-Heon , Kang Hee-Don , Park Byoungnam , Hwang Jun Yeon , Jang Ho Seong , Do Young Rag , Yang Heesun
Published: February 2015

A bicolored white quantum dot-light-emitting diode has been demonstrated using a unique QD combination of blue CdZnS/ZnS and yellow Cu–In–S/ZnS.
Modular construction of macrocycle-based topological polymers via high-efficient thiol chemistry
Authors: Zhao Junfei , Zhou Yanyan , Li Yiwen , Pan Xiangqiang , Zhang Wei , Zhou Nianchen , Zhang Ke , Zhang Zhengbiao , Zhu Xiulin
Published: February 2015

Tadpole-, spiro-shaped, fused-dicyclic tadpole and other complex macrocycle-based topological polymers were modularly constructed via thiol-X chemistry.
Study on thermal degradation mechanism of a cured aldehyde-functional benzoxazine
Authors: Li Chao , Ran Qichao , Zhu Rongqi , Gu Yi
Published: February 2015

Thermal degradation mechanism of a cured aldehyde-functional benzoxazine.
Structure of fully asymmetric mixed electrolytes around a charged nanoparticle: a density functional and simulation investigation
Authors: Patra Chandra N.
Published: February 2015

A systematic study on the structure of mixed electrolytes with arbitrary size and charge asymmetry around a charged nanoparticle is carried out using density functional theory and Monte Carlo simulation.
Heterogeneous catalysts for advanced bio-fuel production through catalytic biomass pyrolysis vapor upgrading: a review
Authors: Asadieraghi Masoud , Ashri Wan Daud Wan Mohd , Abbas Hazzim F.
Published: February 2015

Catalytic biomass pyrolysis vapor upgrading presently seems to be a techno-economical process toward production of fuel-like components. However, selection of stable and productive catalyst(s) to yield desirable chemicals with low coke formation is a great challenge.
The effects of hydroxyapatite nano whiskers and its synergism with polyvinylpyrrolidone on poly(vinylidene fluoride) hollow fiber ultrafiltration membranes
Authors: Zhang Xuan , Lang Wan-Zhong , Xu Hai-Peng , Yan Xi , Guo Ya-Jun
Published: February 2015

By introducing hydroxyapatite (HAP) nano whiskers as well as polyvinylpyrrolidone (PVP), poly(vinylidene fluoride) (PVDF)/PVP/HAP hollow fiber membranes were fabricated with the wet spinning method.
Carbon dioxide stripping through water by porous PVDF/montmorillonite hollow fiber mixed matrix membranes in a membrane contactor
Authors: DashtArzhandi M. Rezaei , Ismail A. F. , Matsuura T.
Published: February 2015

Hydrophobic montmorillonite-filled polyvinylideneflouride hollow fiber mixed matrix membranes were fabricated via wet phase inversion method to meet the requirements of stripping process through membrane contactor at elevated temperatures.
Control of manganese dioxide crystallographic structure in the redox reaction between graphene and permanganate ions and their electrochemical performance
Authors: Ji Chenchen , Ren Haoqi , Yang Shengchun
Published: February 2015

MnO2 crystallographic structure was well controlled in the redox reaction between graphene and permanganate ions.
Theoretical studies on a carbonaceous molecular bearing: association thermodynamics and dual-mode rolling dynamics
Authors: Isobe Hiroyuki , Nakamura Kosuke , Hitosugi Shunpei , Sato Sota , Tokoyama Hiroaki , Yamakado Hideo , Ohno Koichi , Kono Hirohiko
Published: February 2015

The dynamics of a carbonaceous molecular bearing were investigated by DFT methods to reveal dual-mode motions with a minute energy barrier.
Zn–Al layered double oxides as high-performance anode materials for zinc-based secondary battery
Authors: Huang Jianhang , Yang Zhanhong , Wang Ruijuan , Zhang Zheng , Feng Zhaobin , Xie Xiaoe
Published: February 2015

In this work, Zn–Al layered double oxides (Zn–Al-LDO) were prepared via a facile hydrothermal method, followed by calcination treatment in an air atmosphere, and evaluated as anode materials of Zn/Ni batteries.
Multifunctional gadolinium-labeled silica-coated Fe3O4 and CuInS2 nanoparticles as a platform for in vivo tri-modality magnetic resonance and fluorescence imaging
Authors: Shen Jianhua , Li Yunfeng , Zhu Yihua , Yang Xiaoling , Yao Xiuzhong , Li Jun , Huang Guangjian , Li Chunzhong
Published: February 2015

Gd-labeled, peptide-conjugated Fe3O4 NPs and fluorescent CuInS2 QDs were fabricated for imaging of pancreatic cancer.
A proton-responsive ensemble using mesocellular foam supports capped with N,O-carboxymethyl chitosan for controlled release of bioactive proteins
Authors: Gan Qi , Zhu Jiaoyang , Yuan Yuan , Liu Honglai , Zhu Yihua , Liu Changsheng
Published: February 2015

A novel pH-responsive mesocellular foam-based nanocarrier was fabricated by the covalent assembly of a water-solubleN,O-carboxymethyl chitosanviathe crosslinking of GPTMS for controlled release of proteins and maintaining their bioactivity.
Controllable multicolor switching of oligopeptide-based mechanochromic molecules: from gel phase to solid powder
Authors: Ma Zhiyong , Wang Zhijian , Xu Zejun , Jia Xinru , Wei Yen
Published: February 2015

Fluorescent gels of two organic molecules with the same chromophores but different numbers of phenylalanine spacer units are reported as novel multicolored mechanochromic materials.
Zipper-like molecular packing of donor–acceptor conjugated co-oligomers based on perylenediimide
Authors: Biniek Laure , Schwartz Pierre-Olivier , Zaborova Elena , Heinrich Benoît , Leclerc Nicolas , Méry Stéphane , Brinkmann Martin
Published: February 2015

The structure of perylene diimide co-oligomers used in organic photovoltaics is uncovered by TEM and GIXD on highly oriented films.
Betriebliche Gesundheitsförderung in kleinen, mittleren und großen Unternehmen des Gesundheitssektors – Häufigkeit, Handlungsgründe der Unternehmensleitungen und Hürden der Realisierung
Authors: Schaefer E. , Drexler H. , Kiesel J.
Published: February 2015

Ziel: Gewinn von Erkenntnissen zur Aktivität in betrieblicher Gesundheitsförderung (BGF) von kleinen und mittleren Unternehmen (KMU) im Vergleich zu Großunternehmen in Mittelfranken. Ein Adressdatensatz von Betrieben aus der Medizinbranche stand zur Verfügung. Neben den Aktivitäten in der BGF wurden insbesondere Hinderungsgründe aus Sicht der Unternehmensleitung und deren Wunsch nach einer Kooperation in einem Unternehmensnetzwerk ermittelt.

Methodik: Die Erhebung der Daten für diese Querschnittstudie erfolgte durch standardisierte Telefoninterviews. Interviewt wurde die Geschäftsleitung, falls dies nicht möglich war, eine benannte Vertretung. 106 Betriebe wurden kontaktiert. Die Studienergebnisse wurden mittels deskriptiver Statistik in SPSS® 20 und mit Methoden der qualitativen und quantitativen Forschung ausgewertet.

Ergebnisse: 80 Betriebe konnten erreicht und befragt werden, was einer Rücklaufquote von 75,5% entspricht. Mehr als die Hälfte (68,8%) der Unternehmen haben bisher einzelne oder mehrere Maßnahmen zur betrieblichen Gesundheitsförderung, vor allem in den Bereichen Ergonomie/Arbeitsumgebung oder Bewegung, durchgeführt. Eine Betrachtung nach Betriebsgröße bestätigt bisherige Studienergebnisse: Mit steigender Unternehmensgröße steigt die relative Häufigkeit von BGF-Maßnahmen. Die Beweggründe für BGF reichen von der Gesunderhaltung der Mitarbeiter (38,2%) bis hin zur Aussage, dass BGF zur Unternehmenskultur gehöre (9,1%). Als erfolgreich betrachten 81,8% der Betriebe ihre Maßnahmen zur Gesundheitsförderung. 80,0% der Unternehmen mit BGF wurden überdies durch einen Partner, wie bspw. eine Krankenkasse (43,2%) unterstützt. Diejenigen, die bisher noch nicht in der BGF aktiv waren, nennen als Grund hierfür am häufigsten, dass sie über BGF noch nicht nachgedacht haben (44,0%). 44,0% der Unternehmen ohne BGF würden zudem gerne aktiv werden. Die Frage, ob die Firmen eine Zusammenarbeit innerhalb eines Unternehmensnetzwerks zur betrieblichen Gesundheitsförderung begrüßen würden, bejahten 65,5% der Unternehmen mit BGF und 56,0% der Unternehmen ohne BGF. Am wichtigsten ist ihnen hier der gegenseitige Austausch.

Schlussfolgerung: Die Ergebnisse dieser Studie zeigen, dass fast die Hälfte derjenigen Unternehmen, die noch keine BGF etabliert haben, gerne aktiv werden will. Für eine breitere Etablierung der BGF, bietet sich besonders für KMU die Zusammenarbeit in Unternehmensnetzwerken an, am besten unterstützt durch externe Experten, wie z. B. Krankenkassen, Berufsgenossenschaften oder Universitätsinstitute.
Characterization of Lorenz number with Seebeck coefficient measurement
Authors: Kim Hyun-Sik , Gibbs Zachary M. , Tang Yinglu , Wang Heng , Snyder G. Jeffrey
Published: February 2015

In analyzing zT improvements due to lattice thermal conductivity (κL) reduction, electrical conductivity (σ) and total thermal conductivity (κTotal) are often used to estimate the electronic component of the thermal conductivity (κE) and in turn κL from κL = ∼ κTotal − LσT. The Wiedemann-Franz law, κE = LσT, where L is Lorenz number, is widely used to estimate κE from σ measurements. It is a common practice to treat L as a universal factor with 2.44 × 10−8 WΩK−2 (degenerate limit). However, significant deviations from the degenerate limit (approximately 40% or more for Kane bands) are known to occur for non-degenerate semiconductors where L converges to 1.5 × 10−8 WΩK−2 for acoustic phonon scattering. The decrease in L is correlated with an increase in thermopower (absolute value of Seebeck coefficient (S)). Thus, a first order correction to the degenerate limit of L can be based on the measured thermopower, |S|, independent of temperature or doping. We propose the equation: L=1.5+exp−|S|116 (where L is in 10−8 WΩK−2 and S in μV/K) as a satisfactory approximation for L. This equation is accurate within 5% for single parabolic band/acoustic phonon scattering assumption and within 20% for PbSe, PbS, PbTe, Si0.8Ge0.2 where more complexity is introduced, such as non-parabolic Kane bands, multiple bands, and/or alternate scattering mechanisms. The use of this equation for L rather than a constant value (when detailed band structure and scattering mechanism is not known) will significantly improve the estimation of lattice thermal conductivity.
Detection of bifurcations in noisy coupled systems from multiple time series
Authors: Williamson Mark S. , Lenton Timothy M.
Published: February 2015

We generalize a method of detecting an approaching bifurcation in a time series of a noisy system from the special case of one dynamical variable to multiple dynamical variables. For a system described by a stochastic differential equation consisting of an autonomous deterministic part with one dynamical variable and an additive white noise term, small perturbations away from the system's fixed point will decay slower the closer the system is to a bifurcation. This phenomenon is known as critical slowing down and all such systems exhibit this decay-type behaviour. However, when the deterministic part has multiple coupled dynamical variables, the possible dynamics can be much richer, exhibiting oscillatory and chaotic behaviour. In our generalization to the multi-variable case, we find additional indicators to decay rate, such as frequency of oscillation. In the case of approaching a homoclinic bifurcation, there is no change in decay rate but there is a decrease in frequency of oscillations. The expanded method therefore adds extra tools to help detect and classify approaching bifurcations given multiple time series, where the underlying dynamics are not fully known. Our generalisation also allows bifurcation detection to be applied spatially if one treats each spatial location as a new dynamical variable. One may then determine the unstable spatial mode(s). This is also something that has not been possible with the single variable method. The method is applicable to any set of time series regardless of its origin, but may be particularly useful when anticipating abrupt changes in the multi-dimensional climate system.
Bifurcation characteristics and safe basin of MSMA microgripper subjected to stochastic excitation
Authors: Zhu Z. W. , Li X. M. , Xu J.
Published: February 2015

A kind of magnetic shape memory alloy (MSMA) microgripper is proposed in this paper, and its nonlinear dynamic characteristics are studied when the stochastic perturbation is considered. Nonlinear differential items are introduced to explain the hysteretic phenomena of MSMA, and the constructive relationships among strain, stress, and magnetic field intensity are obtained by the partial least-square regression method. The nonlinear dynamic model of a MSMA microgripper subjected to in-plane stochastic excitation is developed. The stationary probability density function of the system’s response is obtained, the transition sets of the system are determined, and the conditions of stochastic bifurcation are obtained. The homoclinic and heteroclinic orbits of the system are given, and the boundary of the system’s safe basin is obtained by stochastic Melnikov integral method. The numerical and experimental results show that the system’s motion depends on its parameters, and stochastic Hopf bifurcation appears in the variation of the parameters; the area of the safe basin decreases with the increase of the stochastic excitation, and the boundary of the safe basin becomes fractal. The results of this paper are helpful for the application of MSMA microgripper in engineering fields.
Ionic conductivity and dielectric permittivity of PEO-LiClO4 solid polymer electrolyte plasticized with propylene carbonate
Authors: Das S. , Ghosh A.
Published: February 2015

We have studied ionic conductivity and dielectric permittivity of PEO-LiClO4 solid polymer electrolyte plasticized with propylene carbonate. Differential scanning calorimetry and X-ray diffraction studies confirm minimum volume fraction of crystalline phase for the polymer electrolyte with 40 wt. % propylene carbonate. The ionic conductivity exhibits a maximum for the same composition. The temperature dependence of the ionic conductivity has been well interpreted using Vogel-Tamman-Fulcher equation. Ion-ion interactions in the polymer electrolytes have been studied using Raman spectra and the concentrations of free ions, ion-pairs and ion-aggregates have been determined. The ionic conductivity increases due to the increase of free ions with the increase of propylene carbonate content. But for higher content of propylene carbonate, the ionic conductivity decreases due to the increase of concentrations of ion-pairs and ion-aggregates. To get further insights into the ion dynamics, the experimental data for the complex dielectric permittivity have been studied using Havriliak–Negami function. The variation of relaxation time with temperature obtained from this formalism follows Vogel-Tamman-Fulcher equation similar to the ionic conductivity.
Theoretical study of hydration in Y2Mo3O12: Effects on structure and negative thermal expansion
Authors: Wu Ming-Yi , Wang Lei , Jia Yu , Guo Zheng-Xiao , Sun Qiang
Published: February 2015

We report ab-initio calculations of water absorption in Y2Mo3O12. The absorption geometry of H2O in Y2Mo3O12 and the binding property between H2O and Y2Mo3O12 have been first identified. Our calculated results show that water is chemisorbed in Y2Mo3O12 with O of the water binding to the Y3+ cation, which is further strengthened by hydrogen bonding between each of the hydrogen atoms of H2O and the bridge O in Y2Mo3O12, shared by polyhedrons YO6 and MoO4. The absorption of water leads to a reduced angle of Y-O-Mo and shortened Y-Mo distance, and consequently volume contraction of the material, almost linearly with the increasing number of water molecules per unit cell, up to eight in total. In addition, our phonon calculation show that the transverse vibration of Y-O-Mo is restricted due to water absorption, which in turn hinders the NTE, as it is mainly originated from this vibrational mode. Our results clarify further the fundamental mechanisms of the large volume shrinkage and the lost NTE of the framework oxide due to water absorption.
Modeling of a quantized current and gate field-effect in gated three-terminal Cu2-αS electrochemical memristors
Authors: Zhang Y. , Mou N. I. , Pai P. , Tabib-Azar M.
Published: February 2015

Memristors exhibit very sharp off-to-on transitions with a large on/off resistance ratio. These remarkable characteristics coupled with their long retention time and very simple device geometry make them nearly ideal for three-terminal devices where the gate voltage can change their on/off voltages and/or simply turn them off, eliminating the need for bipolar operations. In this paper, we propose a cation migration-based computational model to explain the quantized current conduction and the gate field-effect in Cu2-αS memristors. Having tree-shaped conductive filaments inside a memristor is the reason for the quantized current conduction effect. Applying a gate voltage causes a deformation of the conductive filaments and thus controls the SET and the RESET process of the device.
Combined reactor neutron beam and 60Co γ-ray radiation effects on CMOS APS image sensors
Authors: Wang Zujun , Chen Wei , Sheng Jiangkun , Liu Yan , Xiao Zhigang , Huang Shaoyan , Liu Minbo
Published: February 2015

The combined reactor neutron beam and 60Co γ-ray radiation effects on complementary metal-oxide semiconductor (CMOS) active pixel sensors (APS) have been discussed and some new experimental phenomena are presented. The samples are manufactured in the standard 0.35-μm CMOS technology. Two samples were first exposed to 60Co γ-rays up to the total ionizing dose (TID) level of 200 krad(Si) at the dose rates of 50.0 and 0.2 rad(Si)/s, and then exposed to neutron fluence up to 1 × 1011 n/cm2 (1-MeV equivalent neutron fluence). One sample was first exposed to neutron fluence up to 1 × 1011 n/cm2 (1-MeV equivalent neutron fluence), and then exposed to 60Co γ-rays up to the TID level of 200 krad(Si) at the dose rate of 0.2 rad(Si)/s. The mean dark signal (KD), the dark signal non-uniformity (DSNU), and the noise (VN) versus the total dose and neutron fluence has been investigated. The degradation mechanisms of CMOS APS image sensors have been analyzed, especially for the interaction induced by neutron displacement damage and TID damage.
Effects of potassium diformate on the gastric function of weaning piglets
Authors: Xia S. , Yao W. , Zou B. , Lu Y. , Lu N. , Lei H. , Xia D.
Published: February 2015

Potassium diformate (KDF), as an acidifier, has been shown to improve growth performance in pigs, but it is not yet known whether KDF regulates gastric function. Thus, the objective of the present study was to investigate the effects of dietary KDF on gastric function in weaning piglets. One hundred and eighty Landrace × Large White piglets (bodyweight = 5.80 ± 0.15 kg) were weaned at 28 days old and randomly allocated into two groups, with six pens in each group and 15 piglets in each pen. Piglets in the control group were fed the basal diet, whereas the KDF-treated group was fed the basal diet supplemented with 10 g/kg KDF. After 35 days of feeding, the KDF treatment improved the bodyweight (P = 0.034) and reduced the relative weight of stomach (P = 0.050), decreased the hydrochloric acid concentration (P = 0.016) in the gastric digesta and the pepsin activity in the gastric oxyntic mucosa (P = 0.001) and increased the lactic acid concentration (P = 0.001) in the gastric digesta. Furthermore, KDF treatment increased the level of somatostatin (SS) (P = 0.009), but did not change the concentration of gastrin (P = 0.497) and the activity of H+-K+-ATPase (P = 0.575) in the gastric oxyntic mucosa. However, KDF treatment downregulated the expression of SS mRNA in the gastric oxyntic mucosa (P = 0.031) and upregulated the mRNA expression of gastrin (P < 0.001) and H+-K+-ATPase (P < 0.001) in the gastric oxyntic mucosa. These results suggest that the effects of KDF on weaning piglets may be related to the regulation of gastric function gene expression.
Genetic parameters for calving difficulty using complex genetic models in five beef breeds in Australia
Authors: Jeyaruban M. G. , Johnston D. J. , Tier B. , Graser H.-U.
Published: February 2015

Data on Angus (ANG), Charolais (CHA), Hereford (HER), Limousin (LIM) and Simmental (SIM) cattle were used to estimate genetic parameters for calving difficulty (CD), birthweight (BWT) and gestation length (GL) using threshold-linear models and to examine the effect of inclusion of random effect of sire × herd interaction (SxH) in the models. For models without SxH, estimated heritabilities for direct genetic effect of CD were 0.24 (±0.02), 0.22 (±0.04), 0.31 (±0.02), 0.22 (±0.04) and 0.17 (±0.01) for ANG, CHA, HER, LIM and SIM, respectively, whereas maternal heritabilities ranged from 0.13 to 0.20. Estimated heritabilities for direct genetic effect of BWT were 0.38 (±0.01), 0.37 (±0.03), 0.46 (±0.01), 0.35 (±0.02) and 0.36 (±0.01) for ANG, CHR, HER, LIM and SIM, respectively, whereas maternal heritabilities ranged from 0.08 to 0.11. Estimated heritabilities for direct genetic effect of GL were 0.59 (±0.02), 0.42 (±0.04), 0.50 (±0.03), 0.45 (±0.04) and 0.42 (±0.03) for ANG, CHR, HER, LIM and SIM, respectively, whereas maternal heritabilities ranged from 0.03 to 0.09. Genetic correlations between direct genetic effects of CD with BWT were highly positive and with GL were moderately positive for all five breeds. Estimated genetic correlations between direct genetic effects and maternal genetic effects (rdm) ranged across the five breeds from –0.40 (±0.05) to –0.16 (±0.02), –0.41 (±0.03) to –0.27 (±0.08) and –0.47 (±0.10) to –0.06 (±0.12) for BWT, GL and CD, respectively. Fitting SxH interaction as additional random effect significantly increased the log-likelihood for analyses of BWT, GL and CD of all breeds, except for GL of CHA. The estimated heritabilities were less than or equal to the estimates obtained with models omitting SxH. The rdm increased (i.e. became less negative) for BWT, GL and CD of all five breeds. However, the increase for GL was not substantially high in comparison to the increase observed for BWT and CD. Genetic parameters obtained for BWT, GL and CD, by fitting SxH as an additional random effect, are more appropriate to use in the genetic evaluation of calving ease in BREEDPLAN.
Genetic variability detected at the lactoferrin locus (LTF) in the Italian Mediterranean river buffalo
Authors: Pauciullo Alfredo , Ramunno Luigi , Macciotta Nicolò P. P. , Gaspa Giustino , Coletta Angelo , Apicella Elisa , Gallo Daniela , Cosenza Gianfranco
Published: February 2015

Lactoferrin (LTF) is a multi-functional protein belonging to the whey protein fractions of milk. The gene LTF encoding for such protein is considered a potential candidate for body measurement, milk composition and yield. This study reports on the genetic variability at the LTF locus in the Italian Mediterranean river buffalo and its possible association with milk yield. Eleven polymorphic sites were found in the DNA fragment spanning exons 15–16. In particular, intron 15 was extremely polymorphic with nine single nucleotide polymorphisms (SNPs) detected, whereas the remaining two SNPs were exonic mutations (g.88G > A at exon 15 and g.1351G > A at exon 16) and both synonymous. The genotyping of the informative samples evidenced three haplotypes, whose frequencies were 0.6, 0.3 and 0.1, respectively, whereas the analysis of the exonic SNPs showed a perfect condition of linkage disequilibrium (g.88A/g.1351G and g.88G/g.1351A). The association study carried out by using the SNP g.88G > A showed that buffalo LTF gene has no statistically significant influence on daily milk yield. This study adds knowledge to the genetic variability of a species less investigated than the other ruminant species. These findings may serve as a useful tool for large-scale screening of buffalo populations.
Bovine STAT5A gene polymorphism and its influence on growth traits in Podolica breed
Authors: Selvaggi Maria , D'Alessandro Angela Gabriella , Dario Cataldo
Published: February 2015

Signal transducers and activators of transcription (STAT) are latent cytoplasmic transcription factors that mediate the actions of a variety of peptide hormones and cytokines within target cells. STAT5A is the main mediator of growth hormone action on target genes and plays a key role as intracellular mediator of prolactin signalling. In this study, the T→C nucleotide polymorphism at position 12 743 in exon 16 of the bovine STAT5A gene was investigated with polymerase chain reaction-restriction fragment length polymorphism in a sample of Podolica young bulls. The Podolica breed derives from Bos primigenius podolicus (forebears of the modern Bos taurus), it has been present in Italy for a very long time and represents yet another example of successful biological adaptation to a hostile environment. The aims of this study were to estimate the allele and genotype frequencies in Podolica breed and to investigate a possible relationship between this polymorphism and some growth performance traits. The observed frequencies of C and T alleles were 0.344 and 0.656, respectively. The TT genotype was the most frequent in the studied population followed by TC and CC ones. Moreover, the animals carrying TT genotypes seem to show an initial faster growth, which determined higher bodyweight at 90 and 270 days of age; conversely, CC individuals exhibit a faster growth in the post-weaning period achieving the higher bodyweight at 450 days of age.
Water-Soluble Poly(ε-caprolactone)-Paclitaxel Prodrugs Toward an Efficient Drug Delivery System
Authors: Wang Ji , Sun Huanjiao , Li Deshan , Yuan Jie , Zhang Xuefei , Tang Haoyu
Published: February 2015

In this paper, poly(ϵ-caprolactone)-graft-carboxylic acid (P(α-C2CL)) was prepared via a thio-bromo click reaction between mercaptosuccinic acid and poly(α-bromo-ϵ-caprolactone). It is readily soluble in aqueous solutions (pH 5.5–9.8) due to the presence of carboxylic groups in each repeating unit. A series of water-soluble P(α-C2CL)-paclitaxel prodrugs with high drug contents (up to 41.4 wt-%) was prepared by esterification. Meanwhile, methyl tetrazolium (MTT) assays showed that P(α-C2CL)-paclitaxel prodrugs exhibited a high antitumour effect on A549 and MCF-7 cells. These prodrugs have appeared as a highly versatile and potent platform for cancer therapy.
Dissolved organic carbon characteristics in an acidified groundwater-dependent ecosystem
Authors: Daud Azra Mat , McDonald Suzanne , Oldham Carolyn E.
Published: February 2015

Quantifying and characterising dissolved organic carbon (DOC) is critical to understanding its role in aquatic ecosystems. This is particularly challenging in acidic groundwater-dependent ecosystems, where low pH and high concentrations of Fe affect DOC characterisation. We investigated the variability in DOC concentrations and chemical structure in an acidic wetland, using UV visible spectrophotometry, a range of digestion methods and subsequent TOC analysis, high-pressure size exclusion chromatography (HPSEC) and rapid fractionation techniques. HPSEC results showed that increasing the pH from an original pH 2.3 to a neutral pH reduced the column adsorption of organic carbon, but did not change molecular weight distributions. Principal component analysis suggested that iron concentrations had a more direct effect on molecular structure than pH. The pH, Fe concentrations and DOC characteristics were highly dynamic and spatially variable, and were linked to surface water–groundwater connectivity, as well as horizontal connectivity of surface ponding. The changing pH and Fe concentrations affected DOC concentration and molecular structure with expected effects on bioavailability of DOC.