bluuebunny/crossref_metadata_2025 huggingface dataset:
Les enjeux du Projet territorial de Santé mentale 69
Authors: Franck Nicolas , Mariotti Pascal , Descamp Céline
Published: January 2024

Résumé Dans cet article, le directeur général du Vinatier, le Pr Nicolas Franck et Céline Descamp responsable du PTSM 69, évoquent la transformation des pratiques dans l’hôpital et sur le territoire (69). Une nouvelle CME, un nouveau projet médical centré sur le rétablissement et une refonte du pôle « centre rive gauche » ont permis de modifier la réponse aux besoins de soins du territoire, de raccourcir les délais d’accès aux soins et la durée d’hospitalisation. Les auteurs insistent sur le rythme rapide des changements opérés, sur l’intérêt des interventions des pairs-aidants, de l’aide aux aidants ou l’information de la population. Tout cela intégré rapidement dans un paysage qui est celui du PTSM avec l’engagement de beaucoup d’acteurs sur le modèle « rétablissement » et la participation des personnes concernées. La rapidité de l’accès aux soins, la prévention, la promotion de la santé et l’évaluation sont des engagements pour tous.
Les cartes sémantiques en typologie des langues. La médiation iconique entre qualification et quantification dans des représentations visuelles du discours linguistique
Authors: Badir Sémir , Polis Stéphane
Published: January 2024

Depuis les années 1980, les linguistes travaillant dans le champ de la typologie des langues font usage de représentations graphiques regroupées sous l’étiquette de « cartes sémantiques » (« semantic maps »). La description de ce corpus relativement hétérogène permet d’en dégager deux grands types : d’une part, des graphes appelés « classical maps » ou « connectivity maps », d’autre part, des graphiques en nuage de points appelés « proximity maps » ou « similarity maps ». Une analyse sémiotique montre que ces types correspondent à des régimes et visées épistémiques distincts. Les schémas du premier type présentent les résultats d’une démarche hypothético-déductive et servent d’explication générale. Les seconds dépendent au contraire d’une analyse inductive et s’offrent à l’interprétation. À partir de l’observation de graphes apparus dans des publications récentes, on montrera que des tentatives d’hybridation entre geste de qualification et geste de quantification révèlent une médiation iconique, dont la fonction mérite d’être mieux appréciée pour cerner les enjeux sous-jacents à l’utilisation des diagrammes dans le discours linguistique.
Place(s) et limite(s) des diagrammes en sémantique cognitive
Authors: Col Gilles
Published: January 2024

La sémantique cognitive a comme postulat et méthodologie de rejeter une approche vériconditionnelle et formelle de la sémantique. Ce rejet passe par un recours à des « diagrammes » qui vont des dessins naïfs de Vandeloise (1986) pour décrire l’espace, jusqu’aux représentations dynamiques de Fauconnier et Turner (2002) pour illustrer l’intégration conceptuelle, en passant par des schémas plus statiques comme ceux de Langacker (1987) mais qui tentent malgré tout de saisir la construction du sens. La question centrale des diagrammes en sémantique cognitive est cependant bien celle-ci : comment décrire la construction dynamique du sens avec des diagrammes qui sont généralement statiques ? Nous répondons à cette question en faisant des propositions issues de Col (2017) pour une approche dynamique des diagrammes susceptibles de décrire la progression sémantique d’un énoncé dans son déroulement, diagrammes que nous identifierons comme des « diagrammes de flux » (François, 2021).
Grammaires graphiques
Authors: Mazziotta Nicolas , Kahane Sylvain
Published: January 2024

Ce texte traite de l’inscription des grammaires formelles à l’aide de diagrammes. Au travers de l’examen d’exemples tirés de la grammaire catégorielle, de la tree-adjoining grammar (TAG) et de la grammaire d’unification polarisée (GUP), nous montrons comment les diagrammes inscrivent les opérations nécessaires pour effectuer des calculs tels que la vérification de la structure d’une phrase ou la génération de structures syntaxiques à partir de structure sémantique. Ces opérations sont assemblées dans un métadiagramme, qui établit des relations entre plusieurs diagrammes. Le métadiagramme inscrit visuellement des opérations abstraites ; ce faisant, il autorise l’utilisateur à assigner une valeur à la position relative des entités graphiques sur le plan dans le processus de réflexion, ce qui peut mener à une utilisation créative qui exploite les contraintes formelles posées.
Estimation of the quadratic variation of log prices based on the Itô semi-martingale
Authors: Guo Erlin , Ling Patrick
Published: January 2024

As the availability of high-frequency data becomes more widespread, it has become very popular to model random fluctuations of some econometric variables over time using Itô semi-martingale. An emblematic problem is to estimate the quadratic variation, i.e., the integrated volatility of log prices, using noisy high frequency data with endogenous time and jumps. We propose a methodology that combines the multiple sub-grids and thresholds. First, the sub-sample is used to reduce the effect of the noise. Then, the threshold method is used to get rid of the effect of jumps. Finally, the multiple sub-grids method is used to increase the convergence rate. The asymptotic properties, such as consistency and asymptotic normality, are investigated. Simulation is also included to illustrate the performance of the proposed procedure.
Linear convergence of a primal-dual algorithm for distributed interval optimization
Authors: Wang Yinghui , Wang Jiuwei , Song Xiaobo , Hu Yanpeng
Published: January 2024

In this paper, we investigate a distributed interval optimization problem whose local functions are interval functions rather than scalar functions. Focusing on distributed interval optimization, this paper presents a distributed primal-dual algorithm. A criterion is introduced under which linear convergence to the Pareto solution of distributed interval optimization problems can be achieved without strong convexity. Lastly, a numerical simulation is presented to illustrate the linear convergence of the algorithm that has been proposed.
Fractional operators on the bounded symmetric domains of the Bergman spaces
Authors: Ibrahim Rabha W. , Baleanu Dumitru
Published: January 2024

Mathematics has several uses for operators on bounded symmetric domains of Bergman spaces including complex geometry, functional analysis, harmonic analysis and operator theory. They offer instruments for examining the interaction between complex function theory and the underlying domain geometry. Here, we extend the Atangana-Baleanu fractional differential operator acting on a special type of class of analytic functions with the $ m $-fold symmetry characteristic in a bounded symmetric domain (we suggest the open unit disk). We explore the most significant geometric properties, including convexity and star-likeness. The boundedness in the weighted Bergman and the convex Bergman spaces associated with a bounded symmetric domain is investigated. A dual relations exist in these spaces. The subordination and superordination inequalities are presented. Our method is based on Young's convolution inequality.
Neumann gradient estimate for nonlinear heat equation under integral Ricci curvature bounds
Authors: Liu Hao-Yue , Zhang Wei
Published: January 2024

In this paper, we consider a Li-Yau gradient estimate on the positive solution to the following nonlinear parabolic equation

   \begin{document}$ \frac{\partial}{\partial t}f = \Delta f+af(\ln f)^{p} $\end{document}

with Neumann boundary conditions on a compact Riemannian manifold satisfying the integral Ricci curvature assumption, where $ p\geq 0 $ is a real constant. This contrasts Olivé's gradient estimate, which works mainly for the heat equation rather than nonlinear parabolic equations and the result can be regarded as a generalization of the Li-Yau [P. Li, S. T. Yau, On the parabolic kernel of the Schrödinger operator, Acta Math., 156 (1986), 153–201] and Olivé [X. R. Olivé, Neumann Li-Yau gradient estimate under integral Ricci curvature bounds, Proc. Amer. Math. Soc., 147 (2019), 411–426] gradient estimates.
Markov-switching threshold stochastic volatility models with regime changes
Authors: Ghezal Ahmed , balegh Mohamed , Zemmouri Imane
Published: January 2024

This paper introduces a comprehensive class of models known as Markov-Switching Threshold Stochastic Volatility (MS-TSV) models, specifically designed to address asymmetry and the leverage effect observed in the volatility of financial time series. Extending the classical threshold stochastic volatility model, our approach expresses the parameters governing log-volatility as a function of a homogeneous Markov chain with a finite state space. The primary goal of our proposed model is to capture the dynamic behavior of volatility driven by a Markov chain, enabling the accommodation of both gradual shifts due to economic forces and sudden changes caused by abnormal events. Following the model's definition, we derive several probabilistic properties of the MS-TSV models, including strict (or second-order) stationarity, causality, ergodicity, and the computation of higher-order moments. Additionally, we provide the expression for the covariance function of the squared (or powered) process. Furthermore, we establish the limit theory for the Quasi-Maximum Likelihood Estimator (QMLE) and demonstrate the strong consistency of this estimator. Finally, a simulation study is presented to assess the performance of the proposed estimation method.
Conditional random k satisfiability modeling for k = 1, 2 (CRAN2SAT) with non-monotonic Smish activation function in discrete Hopfield neural network
Authors: Roslan Nurshazneem , Sathasivam Saratha , Azizan Farah Liyana
Published: January 2024

The current development of logic satisfiability in discrete Hopfield neural networks (DHNN)has been segregated into systematic logic and non-systematic logic. Most of the research tends to improve non-systematic logical rules to various extents, such as introducing the ratio of a negative literal and a flexible hybrid logical structure that combines systematic and non-systematic structures. However, the existing non-systematic logical rule exhibited a drawback concerning the impact of negative literal within the logical structure. Therefore, this paper presented a novel class of non-systematic logic called conditional random k satisfiability for k = 1, 2 while intentionally disregarding both positive literals in second-order clauses. The proposed logic was embedded into the discrete Hopfield neural network with the ultimate goal of minimizing the cost function. Moreover, a novel non-monotonic Smish activation function has been introduced with the aim of enhancing the quality of the final neuronal state. The performance of the proposed logic with new activation function was compared with other state of the art logical rules in conjunction with five different types of activation functions. Based on the findings, the proposed logic has obtained a lower learning error, with the highest total neuron variation TV = 857 and lowest average of Jaccard index, JSI = 0.5802. On top of that, the Smish activation function highlights its capability in the DHNN based on the result ratio of improvement Zm and TV. The ratio of improvement for Smish is consistently the highest throughout all the types of activation function, showing that Smish outperforms other types of activation functions in terms of Zm and TV. This new development of logical rule with the non-monotonic Smish activation function presents an alternative strategy to the logic mining technique. This finding will be of particular interest especially to the research areas of artificial neural network, logic satisfiability in DHNN and activation function.
Melnikov functions and limit cycle bifurcations for a class of piecewise Hamiltonian systems
Authors: Hou Wenwen , Han Maoan
Published: January 2024

This study evaluated the number of limit cycles for a class of piecewise Hamiltonian systems with two zones separated by two semi-straight lines. First, we obtained explicit expressions of higher Melnikov functions. Then we applied these expressions to find the upper bounds of the number of limit cycles bifurcated from a period annulus of a piecewise polynomial Hamiltonian system.
Virtualization and Online Engineering of the Administrative Services in Universities
Authors: Kuyumdzhiev Ivan , Petrov Pavel
Published: January 2024

Virtualization and online engineering of services are emerging as key themes that will profoundly influence society and industry in the near and distant future. This paper focuses on the transformation of administrative services in universities into virtual services through online engineering. This transition presents challenges not only to universities in Bulgaria but also worldwide. Given the significant impact of technology on the daily operations of universities, it is evident that the digital divide is an issue worthy of investigation. Disparities in the adoption of online administrative services can and will lead to inconsistencies in the economic development of universities. This article aims to explore some of the challenges associated with virtualization and online engineering of administrative services in universities and offers insights into how to address them.
A fatal case of acute copper sulphate poisoning presenting with methaemoglobinemia and intravascular haemolysis: a case report
Authors: Ranasinghe K. M. I. U. , Thirumavalavan K.
Published: January 2024

Copper sulphate is a common industrial chemical that is rarely used for suicide. Ingestion of more than one gram of copper sulphate causes features of toxicity, mainly severe gastrointestinal tract erosions, methaemoglobinemia, acute kidney injury, intravascular haemolysis, and acute hepatitis. A dose of more than 10g is lethal. The management is mainly supportive. Copper chelation with penicillamine, edetate calcium disodium (EDTA) and British anti-Lewisite (BAL) can be used to minimize the toxicity. Exchange transfusion for severe methemoglobinemia has been attempted with variable success.We report a lethal case of poisoning with 75g of copper sulphate resulting in severe methaemoglobinemia, intravascular haemolysis, gastrointestinal bleeding and multi-organ failure. Exchange transfusion was carried out without success and the patient succumbed to death on the third day of the poisoning. Though it is rare, the fatality of copper sulphate poisoning necessitates proper knowledge about manifestations and management options.
Understanding the modern-era management of cardiac tachyarrhythmias
Authors: Vaseekaran G. , Dunuwille A.
Published: January 2024

Diagnosis and treatment modalities of supraventricular arrhythmias have been changed over the past decade. This article mainly outlines advances in diagnosis and modern-day management of supraventricular tachycardia as well as an overview of the management of wide complex tachyarrhythmias. The role of cardiac electrophysiology study and radiofrequency catheter ablation in the diagnosis and management of a wide variety of supraventricular arrhythmias is also discussed. This article also emphasizes the current evidence-based management of atrial-origin tachyarrhythmias such as atrial flutter and fibrillation.The management of cardiac arrhythmias has changed over the past decade, which is mainly due to improvements in catheter ablation including 3D mapping catheter ablation, improvements in device therapy such as implantable cardioverter defibrillator (ICD) and biventricular pacing therapy (CRT) which have evolved to treat many conditions. Catheter ablation has moved from being a treatment considered only for patients with refractory arrhythmias to a first-line treatment. In the new era, catheter ablation is also used to treat atrial origin tachyarrhythmias such as atrial fibrillation (AF) and atrial flutter as well as ventricular tachycardia (epicardial VT ablation). Improvement of imaging modalities such as 2D/3D echocardiogram and cardiac MRI also play a vital role in the prognosis of ablation particularly in AF and epicardial VT ablation. Improvement in device implantation such as ICD and biventricular pacing also helpful in managing tachyarrhythmia. Modern advancements in cardiac electrophysiology help patients to improve their quality of life and prevent sudden cardiac deaths due to cardiac arrhythmia.
Welcome to Global Cardiology
Authors: Coats Andrew J.S.
Published: January 2024

Welcome to the new journal Global Cardiology! Global Cardiology is a journal devoted to the dissemination of knowledge, impact and research relevant to cardiovascular physicians and other health care practitioners worldwide. We believe that research efforts and improvements in clinical practice must be based on a global research effort and designed to address the global barriers to the effective prevention and treatment of cardiovascular disorders on a worldwide basis. Too often in the past, research has been focused on the needs of wealthy nations, while the knowledge and needs of people in developing countries have been largely ignored [...].
Detection of early heart failure with preserved ejection fraction in metabolic syndrome patients detected as part of a national screening program in middle aged subjects
Authors: Čelutkienė J. , Jakštaitė A.M. , Badarienė J. , Solovjova S. , Slivovskaja I. , Navickas R. , Kazėnaitė E. , Rinkūnienė E. , Čypienė A. , Misiūra J. , Ryliškytė L. , Laucevičius A. , Coats A.J.S.
Published: January 2024

Background: We wished to investigate if community detected Metabolic Syndrome (MetS) is associated with the burden of incipient heart failure with preserved ejection fraction (HFpEF) in the community. Methods and Results: We prospectively studied 148 consecutive MetS patients identified from the Lithuanian High Cardiovascular Risk primary prevention program and investigated them further for unknown HFpEF through cardiopulmonary stress testing as well as assessment of brain natriuretic peptide (BNP) levels and of arterial stiffness. Subjects with a peak oxygen consumption value lower than 90% of predicted and/or BNP≥35 ng/L were categorized as having early phase HFpEF. For comparison of this early phase HFpEF with others already clinically diagnosed with HFpEF, patients with both established HFpEF and MetS were selected retrospectively from patients attending our cardiopulmonary stress testing laboratory (n=38). Two thirds of the screening program derived MetS population (n=96) demonstrated a reduced exercise capacity and/or an elevated BNP, indicating signs of early HFpEF. Both the clinically diagnosed HFpEF and the screening program detected MetS group with early HFpEF demonstrated similarly decreased exercise tolerance evaluated by peak oxygen uptake (79.8±22.1% vs 82.7±14.0%, p>0.05). Analysis of arterial markers in the screening program group revealed statistically significant differences of augmentation index values between groups with and without signs of early HFpEF (p=0.016).Conclusions: A considerable proportion of patients having MetS may be diagnosed with previously undetected early stage HFpEF. The use of objective parameters of exercise capacity and neurohormonal activation might be effectively used for the early detection of HFpEF. Also, early HFpEF in this setting is found to be associated with increased arterial stiffness.
Rationale and design for the peripartum cardiomyopathy in Nigeria (PEACE) registry
Authors: Karaye Kamilu M. , Mohammed Idris Y. , Ogah Okechukwu S. , Okeahialam Basil N.
Published: January 2024

Background: Nigeria probably has the highest burden of peripartum cardiomyopathy (PPCM) in the world. The primary objective is to describe the burden, ventricular remodelling, and outcomes (rehospitalisation rate, cardioembolic events and survival) of PPCM in Nigeria. In the substudies, we aim to describe the relationship between selenium deficiency, oxidative stress and PPCM, the impact of sodium selenite supplementation on cardiac function in PPCM, and the prevalence of selenium deficiency and its relationship with cardiac function in apparently healthy pregnant women. Methods: The main registry and the first substudy are prospective longitudinal studies, while the second substudy is an openlabel randomised trial. 36 study centres across Nigeria have been registered and 10 of them are already recruiting subjects. Patients will be recruited from June to December 2017 and followed up till December 2018. Serum selenium and glutathione peroxidase will be assayed at recruitment for consecutive PPCM patients with left ventricular ejection fraction <45% at 6 months postpartum. 200 subjects with selenium deficiency will be randomised into treatment (selenium selenite 200 μg tablets daily for 3 months) and control arms. In the second substudy, 120 apparently healthy pregnant women will be recruited at 2838 weeks of gestation and reviewed at 68 weeks postpartum, and their serum selenium and glutathione peroxidas levels will be measured at recruitment. Conclusions: This will be the largest systematic evaluation of PPCM in Nigeria, and it is hoped that the information will assist in developing locally applicable treatment guidelines and policies for the disease.
Frequency domain analysis of photoplethysmographic and arterial pressure waveforms for assessing hemodynamics in children with congenital heart surgery
Authors: Jang Hwa-Young , Song In-Kyung , Kim Sung-Hoon , Shin Won-Jung
Published: January 2024

Background: Time-domain parameters are less reliable in children due to increased arterial and chest wall compliance. We assessed the ability of indices derived from frequency analysis of photoplethysmography (PPG) and arterial blood pressure (ABP) waveforms to predict the hemodynamic state in children undergoing congenital heart surgery.Methods: We analyzed waveforms after cardiopulmonary bypass period in 76 children who underwent total repair of congenital heart disease. Amplitude density of baseline and amplitude modulation in PPG and ABP by respiratory frequency were obtained using fast Fourier transform analysis and normalized by cardiac pulse height (representing respiratory modulations in venous blood [PPG-DC%] and in amplitude [PPG-AC%] at respiratory frequency). The ratio of amplitude density of PPG at the cardiac frequency (CF) to ABP-CF was used to assess vascular compliance. We assessed volume replacement (ml/kg) and vasoactive inotropic score (VIS).Results: Children requiring volume replacement > 10 ml/kg (15.8%) showed higher PPG-DC% than those not requiring it (median: 52.4%, 95% CI [24.8, 295.1] vs. 36.7% [10.7, 125.7], P = 0.017). In addition, children with a VIS > 7 (22.4%) showed higher PPG-CF/ABP-CF (3.6 [0.91, 10.8] vs. 1.2 [0.27, 5.5], P = 0.008). On receiver operating characteristic curve analysis, PPG-DC% predicted a higher fluid requirement (area under the curve: 0.71, 95% CI [0.604, 0.816], P = 0.009), while PPG-CF/ABP-CF predicted a higher VIS (0.714, [0.599, 0.812], P = 0.004).Conclusions: Frequency domain analysis of PPG and ABP may assess hemodynamic status requiring fluid or vasoactive inotropic therapy after congenital heart surgery.
Efficacy and Safety of Ultra-rapid Lispro Insulin in Managing Type-1 and Type-2 Diabetes: A Systematic Review and Meta-Analysis
Authors: Dutta Deep , Nagendra Lakshmi , Bhattacharya Saptarshi , Sharma Meha
Published: January 2024

Background:

Mechanistically, subcutaneous ultra-rapid lispro (URLi) is faster than lispro. Whether this translates into a better post-prandial glucose (PPG) and glycemic control in type-1 diabetes (T1DM) and type-2 diabetes (T2DM) is unclear. Hence, we undertook this meta-analysis.

Methods:

Databases were searched for randomized controlled trials (RCTs) involving patients with T1DM/T2DM receiving URLi in intervention-arm, and placebo/prandial insulin as control. The primary outcome was a change in PPG. Secondary outcomes were alterations in glycated haemoglobin (HbA1c), fasting plasma glucose (FPG), time in range (TIR), and adverse events.

Results:

Data from six RCTs (3687 patients) were analyzed. Lispro was the control arm in all RCTs. T1DM patients receiving mealtime URLi had lower HbA1c [mean difference (MD) −0.07%; 95% confidence interval (CI): −0.12 to − 0.01; P = 0.02; I
2 = 42%] and 1-h PPG [MD − 1.18 mmol/L; 95% CI: −1.91 to − 0.44; P = 0.002; I
2 = 100%]. T1DM patients receiving post-meal URLi had comparable HbA1c [MD 0.07%; 95% CI: −0.01 to 0.15; P = 0.07; I
2 = 55%] and 1-h PPG [MD 0.22 mmol/L; 95% CI: −0.80 to 1.24; P = 0.67; I
2 = 100%). T1DM patients on pumps receiving URLi had comparable TIR [MD 1.70; 95% CI: −0.29 to 3.69; P = 0.09; I
2 = 98%], lower time in blood glucose <3 mmol/L with increased infusion-set reactions. T2DM patients receiving mealtime URLi had lower 1-h PPG [MD − 0.66 mmol/L; 95% CI: −0.69 to − 0.63; P < 0.00001; I
2 = 0%(LH), 2-h-PPG [MD − 0.96 mmol/L; 95% CI: −1.00 to − 0.92; P < 0.00001; I
2 = 0%], higher FPG [MD 0.18 mmol/L; 95% CI: 0.11–0.24; P < 0.00001; I
2 = 20%], and higher HbA1c [MD 0.07%; 95% CI: −0.06 to 0.08; P < 0.00001; I
2 = 0%].

Conclusion:

Pre-meal URLi is better than lispro with regard to PPG control. Post-meal URLi is as good as lispro for PPG control. Post-meal URLi is inferior to pre-meal URLi for PPG control.
Sociocrinology: Impact of Social Media on Endocrine Health – A Review
Authors: Khare Jaideep , Kalra Sanjay , Jindal Sushil
Published: January 2024

Social media (SM) refers to social networking sites (SNSs), which are defined as online services that enable individuals to build a public or semi-public profile and give them the opportunity to create a network of contacts and interact. SM affects all aspects of life and may offer new opportunities to explore new experiences and perspectives of life because of its feasibility. But several times, because of feasibility, misinformation is generated intentionally or unintentionally, which spreads rapidly, and such misinformation can affect all aspects of life. However, health-related misinformation can be life-threatening to individuals. Endocrinology is the branch of medicine that deals with endocrine glands and hormones, which regulates mood, growth, development, metabolism and the way our organ works to maintain internal homeostasis. SM usage and endocrine health impact each other in both positive and negative ways. So, in this review, we will discuss about the effect of SM on Endocrine health.
Giant cell arteritis causing mesenteric ischemia without cranial manifestations: Report of an unusual case
Authors: Kushwaha Pritika , Singh Meeta , Bellichuki Priyanka , Singh Rajdeep
Published: January 2024

Giant cell arteritis is a medium to large vessel vasculitis involving most commonly temporal arteries, vertebral and ophthalmic arteries. Giant cell arteritis causing mesenteric ischemia is not so frequent, more so if it occurs without cranial manifestations. Here we present an unusual case of a 26-year-old male patient presenting with subacute intestinal obstruction due to giant cell arteritis leading to mesenteric ischemia.
High expression of SHP2 predicts a promising prognosis in colorectal cancer
Authors: Liu Xibo , Li Mengyao , Chen Lirong , Wen Fei , Zheng Shu , Ge Weiting
Published: January 2024

Background:

Src homology 2 domain-containing phosphatase 2 (SHP2) is hyper-activated in some solid tumors. Previous findings suggest that the expression of SHP2 in colorectal cancer (CRC) may be associated with prognosis. However, validation with large sample data is lacking.

Materials and Methods:

Tissue microarrays containing 860 CRCs and 197 mucosal tissues adjacent to the tumors were constructed. Immunohistochemistry was used to evaluate the expression of SHP2. Differences between SHP2 expression and clinicopathological parameters were evaluated. Kaplan–Meier survival curves and log-rank tests were used to analyze the relationships between SHP2 expression and the overall survival of patients. A Cox proportional hazard regression model was used for univariate and multivariate analyses of prognostic factors.

Results:

SHP2 expression in CRCs tissues was significantly higher than those in adjacent mucosal tissues (P < 0.001). SHP2 expression was related to tumor differentiation, depth of invasion, distant metastasis, vascular tumor thrombus, lymph node metastasis, and TNM classification (P < 0.05). The prognosis of the high-expression group of SHP2 was significantly better than that of the low-expression group (P = 0.008). Univariate analysis showed that the expression of SHP2 was a prognostic factor for CRC (P = 0.008). Multivariate analysis demonstrated that SHP2 remained an independent prognostic factor for CRC (P = 0.033).

Conclusion:

The expression of SHP2 was significantly higher in CRC tissues than in adjacent normal tissues. High expression of SHP2 was associated with a promising outcome, suggesting that SHP2 may be a favorable prognostic indicator of CRC.
Analgesic Efficacy of Suprascapular Nerve Block versus Combined Suprascapular and Axillary Nerve Block in Patients Undergoing Shoulder Arthroscopy: A Prospective, Randomized, Comparative Study
Authors: Ray Subrata , Mitra Anuradha , Sanyal Ramapati , Hussain Tabish , Naz Anjum
Published: January 2024

Background:

Immediate post-operative pain can be severe and is an important outcome measure for patients in shoulder arthroscopic surgeries. Interscalene block is the most widely used and studied technique for post shoulder arthroscopy pain relief and is associated with certain unpleasant adverse effects. Suprascapular nerve block (SSNB) has been suggested as an alternative and safer block. As the suprascapular nerve contributes to 70% of the sensory nerve supply to the shoulder joint, and the axillary circumflex nerve is the other major nerve contributing to 25%; therefore, a combined block of these two nerves should provide more effective pain relief than SSNB alone.

Aim:

This study aimed to compare the efficacy of combined SSNB and axillary nerve block (ANB) with SSNB alone for analgesia after shoulder arthroscopy in terms of level of pain scores, total analgesic consumption, and patient satisfaction in 24 h.

Methods:

Forty-one patients posted for shoulder arthroscopy were randomly allocated into two groups, Group S (n = 20) receiving SSNB and Group C (n = 21) receiving combined SSNB and ANB. Visual Analog Scale (VAS) both at rest and during movement at 1, 3, 6, 12, 24 h, and at the time of first demand, total consumption of analgesics in 24 h and patient satisfaction score at 12 and 24 h were noted.

Statistical Analysis:

The data was analyzed by Student’s t-test, Mann-Whitney U test, and Fisher’s exact test using Graph Pad PRISM 9, a p<0.05 was considered significant.

Results:

The VAS scores both at rest and during movement were significantly less in Group C at 1, 6, 12 h, and at the time of the first demand of analgesic (p<0.05). Compared to Group S, Group C had a longer pain-free duration (154.3 ± 11.41 min vs. 36.60 ± 6.553 min; P < 0.001) and lesser cumulative consumption of pethidine (300.0 ± 8.894 mg vs. 336.8 ± 13.27 mg; P = 0.0256). The satisfaction level was better in Group C at 12 h (P = 0.002) but comparable to the Group S at 24 h (P = 0.0673).

Conclusion:

Combined SSNB and ANB provided better pain relief in first 12 h, better patient satisfaction in the first 12 h and decreased overall consumption of analgesics in the first 24 h compared to SSNB alone.
Opioid-prescribing Practices among Otolaryngology Physicians in Saudi Arabia: A Cross-sectional Study
Authors: Almutairi Nehal G. , Al Zaid Wasan , Alshalan Khalid M. , Alotaibi Fahad Z. , Almutairi Fahad G.
Published: January 2024

Background:

Understanding opioid prescription patterns among otolaryngologists is crucial due to the complexity of procedures and associated pain profiles. This study aims to identify opioid prescription patterns among otolaryngologists in Saudi Arabia and the factors that influence these practices.

Materials and Methods:

This descriptive, cross-sectional study was conducted in secondary and tertiary centers in Saudi Arabia from July 2022 to August 2023. Otolaryngologists, including consultants, fellows, and residents, were invited to participate. The eligibility criteria included actively practicing otolaryngologists in Saudi Arabia, regardless of their position or nationality. Otolaryngologists not involved in clinical practice within Saudi Arabia during the study period were excluded. Simple random sampling was employed to select the participants.

Results:

In this study, 214 otolaryngologists participated. The majority were in the age group of 25–34 years (61.2%) and male (71.5%). Resident otolaryngologists represented 48.6% of the participants. Paracetamol was the most commonly prescribed postoperative pain medication (87.9%), whereas high opioid prescriptions were limited (4.7%), with tramadol being the most prescribed opioid (48.1%). Head-and-neck cancer resection surgeries accounted for the highest opioid prescription rate (65.4%). Otolaryngologists in academic settings had significantly higher rates of prescribing high opioid prescriptions compared to those in the community (P = 0.025). Other sociodemographic characteristics and prescribing behaviors showed no significant associations with opioid prescription patterns (P > 0.05).

Conclusion:

This study revealed limited high opioid prescriptions among otolaryngologists in Saudi Arabia, with higher rates in academic settings.
A Review: Use of Plants for Antioxidant Purposes in Fish Oil Microencapsulation
Authors: Yeşilsu Ahmet Faruk
Published: January 2024

Fish oils, rich in essential n-3 fatty acids like EPA and DHA and constituting approximately 80% unsaturated fatty acids, play a pivotal role in contemporary nutrition. However, the susceptibility of fish oil to oxidation and its off-putting fishy smell present obstacles to its widespread consumption. Microencapsulation, a technique involving the application of protective films, emerges as a viable solution to not only enhance oxidative stability but also mitigate sensory drawbacks.
Despite the considerable global fish consumption, the daily intake of n-3 fatty acids in Western diets often falls short of recommended levels. In regions, where fish consumption is comparatively lower, the utilization of microencapsulated fish oils provides an alternative to guarantee sufficient intake. Commonly used coating materials involve proteins and carbohydrates, and the incorporation of antioxidants, be they synthetic or natural, further augments stability. Natural extracts, including rosemary, blueberry, oregano, and pomegranate peel, exhibit promise as potent antioxidants in the microencapsulation process.
This review explores various studies on microencapsulation of fish oils using different natural antioxidants. The findings highlight the potential of microencapsulation to address challenges in fish oil consumption, making it a promising avenue for improving dietary habits and promoting human health.
ANALISIS PENGARUH FAKTOR-FAKTOR DIMENSI KUALITAS PELAYANAN TERHADAP KEPUASAN NASABAH KSPPS UBASYADA CIPUTAT DENGAN MENGGUNAKAN ANALISIS REGRESI LOGISTIK BINER
Authors: Rokhmah Siti Nuur , Ningsi Besse Arnawisuda
Published: January 2024

Ubasyada Ciputat Sharia Savings and Loans and Financing Cooperative (KSPPS) is a cooperative whose business activities are engaged in savings and loans as the principal of its business, as well as funding, financing, and also food stalls. The results of preliminary studies show that there is a lack of interest in people living around to become cooperative customers. This study aims to determine the influence of service quality dimension factors on customer satisfaction of Ubasyada Ciputat Sharia Savings and Loans and Financing Cooperative (KSPPS) using binary logistic regression analysis. The population and sample as of this writing are 30 priority customers of the Ubasyada Ciputat Savings and Loans and Sharia Financing Cooperative (KSPPS). Data is obtained by distributing questionnaires to customers, then tested for validation and reliability and then carried out Binary Logistic Regression tests. From the results of the analysis, it was obtained that the influence of service quality dimension factors that most influence customer satisfaction of Ubasyada Ciputat Savings and Loans and Sharia Financing Cooperative (KSPPS), namely assurance (X4) and empathy (X5) have a positive effect on customer satisfaction (Y).
KEMAMPUAN BERPIKIR REFLEKTIF PESERTA DIDIK MELALUI MODEL COOPERATIVE LEARNING TIPE STAD BERBANTUAN MIND MAPPING
Authors: Br Ginting Aliya Monika , Haji Saleh , Sumardi Hari
Published: January 2024

The purpose of this study was to find out how the STAD Cooperative Learning and Mind Mapping models helped 8th graders at SMP Negeri 11 Bengkulu City improve their reflective thinking skills. The design in this study used The-Nonequivalent Pretest-Posttest Control Group Design. This research is a quasi-experimental research. The total population in this study were 198 people and were all eighth grade students at SMP Negeri 11 Bengkulu City. The sample of this study consisted of 23 students of class VIII G and 19 students of class VIII H. Each sample class held three meetings during the study. The research data shows that the average value of n-gain in the experimental class is 69.21% which is quite effective, and the total value ranges from 33.23% to 82.61% which is classified as good (A). A value is obtained from learning outcomes using the t-test. (2-tailed) = 0.046 < significant level = 0.05 so that the STAD type cooperative learning model assisted by Mind Mapping is said to be able to improve reflective thinking skills in class VIII students at SMP Negeri 11 Kota Bengkulu
PENGARUH MODEL PEMBELAJARAN MISSOURI MATHEMATICS PROJECT (MMP) TERHADAP KEMAMPUAN PENALARAN DAN PEMECAHAN MASALAH MATEMATIKA PADA SISWA MTS JA-ALHAQ KOTA BENGKULU
Authors: Fata Ridwanul , Haji Saleh , Sumardi Hari
Published: January 2024

This research aims to determine the influence of the Missouri Mathematics Project (MMP) learning model on the mathematical reasoning and problem solving abilities of Mts Ja-Alhaq students in Bengkulu City. This research uses the Quasi Experiment method. Data collection was carried out through tests. Data analysis used the Ancova test. The sample for this research was MTs Ja-alHaq students in Bengkulu City. The results of the research show that: (1) There is a linear influence of covariates on students' mathematical problem reasoning abilities in learning the Missouri Mathematics Project (MMP) with an influence of 50,7%. (2) There is a linear influence of covariates on students' mathematical problem solving in Missouri Mathematics Project (MMP) learning with a large influence of 14.6%. (3) There is an influence of Missouri Mathematics Project (MMP) learning on students' mathematical problem reasoning abilities with an influence of 78 %. (4) There is an influence of Missouri Mathematics Project (MMP) learning on students' mathematical problem solving abilities with an influence of 55,5%. (5) Students' achievement of mathematical problem reasoning abilities in Missouri Mathematics Project (MMP) learning is better than those taught through conventional learning. (6) Students' mathematical problem solving achievements in Missouri Mathematics Project (MMP) learning are better than those taught through conventional learning
ANALISIS UMUR REPRODUKSI PALING AWAL DAN PALING AKHIR SERTA PUNCAK FERTILITAS PADA WANITA DI SETIAP KABUPATEN DAN KOTA DI PROVINSI BANTEN
Authors: Sukandar Rani Septiani , Hakim Lukmanul , Huda Miftahul
Published: January 2024

The birth rate (fertility) is one of the factors that influences the increase in population. Banten Province has 8 districts and cities with different fertility rates. One of the fertility indicators presented in the Long Form SP2020 data is Birth Rate data by Age Group / Age Specific Fertility Rate (ASFR). The aim of this research is to determine the earliest, latest reproductive age and the age of women who have the highest fertility rates in each district and city in Banten Province. The skewness (measure of slope) and kurtosis (measure of sharpness) values of the continuous curve formed will also be studied. ASFR data presented by the Central Statistics Agency (BPS) is discrete data. Fertility rates will be approached using the MBF (Modified Beta Function) continuous fertility model. In this research, information was obtained that the earliest reproductive age in Banten Province was 15.64 years. This happened to women in Lebak Regency. Meanwhile, the latest reproductive age in Banten Province is 49.85 years. This happened to women in Pandeglang Regency. It can also be seen that the highest peak fertility rate for the population of Banten Province occurred in women aged 27.54 years in the Cilegon City area, with a peak fertility value of 0.13055. Apart from being based on calculations, this is in accordance with the curve visualization carried out using Mathematica software. The highest skewness value occurs in the continuous fertility curve for the Lebak Regency area. This means that Lebak Regency has the most left-leaning curve. All continuous fertility curves in districts and cities in Banten Province have a platykurtic distribution (flat curve) because the kurtosis value is smaller than 0.263
IS THE EMPLOYMENT SITUATION IN INDONESIA FAVORABLE? IMPLEMENTATION OF VERHULST MODEL DIFFERENTIAL EQUATION
Authors: Novika Fanny
Published: January 2024

This research aims to calculate the limit number of workers and unemployment in each province of Indonesia which is estimated to use Carrying Capacity and calculate the employment growth rate of each province in Indonesia. This calculation will help to identify provinces in Indonesia where the growth rate of the working population is negative, the unemployment rate is positive. All of these calculations use the Verhulst Model Differential Equation. The data used in this research is secondary data obtained from the internet from the official website of the BPS-Statistics Indonesia regarding the Labor Force Situation in Indonesia from 2020-2023. The provinces with a lower working population growth rate, especially have negative value demands particular focus on labor absorption that are West Papua, Central Sulawesi that have high level warning status as well as Maluku and Bali that have medium level warning status. Besides the province with a greater unemployment population growth rate, especially has positive value demands particular focus on labor absorption that is Central Java that have medium level warning status
BENTUK EKSPLISIT RUMUS BEDA MAJU DAN BEDA MUNDUR UNTUK TURUNAN KE-N DENGAN ORDE KETELITIAN KE-N BERDASARKAN DERET TAYLOR
Authors: Putra Ikhsan Fachriansyah , Syafwan Mahdhivan , Helmi Monika Rianti , Nazra Admi
Published: January 2024

In this paper, we aim to derive the explicit forms of forward and backward difference formulas based on the Taylor series. These formulas are employed to approximate the N-th derivative of a single-variable function with N-th order accuracy. The explicit formula is determined by utilizing the properties of the determinant of the Vandermonde matrix. Subsequently, we apply the obtained formulas to an example case involving a first-order ordinary differential equation
ANALISIS KEMAMPUAN PEMBUKTIAN MATEMATIS PADA MATA KULIAH TEORI RING DITINJAU DARI PENDIDIKAN SEKOLAH MENENGAH
Authors: Agustyaningrum Nina , Pradanti Paskalia , Krisma Dita Aldila
Published: January 2024

Mathematical proof is a crucial component in studying mathematics, especially at advanced levels. Previous research has reported that many students face difficulties in solving mathematical proof problems, including in rings theory course. This study aims to determine the level of students' mathematical proof abilities in ring theory course and to compare these abilities based on their school backgrounds. This research employs a quantitative descriptive approach followed by comparative analysis. The subjects were 30 students from the mathematics education program taking rings theory course at Tidar University. The research instruments include tests, questionnaire, and interviews guidelines. Data analysis of the test results was conducted using descriptive statistic and one-way ANOVA followed by Tukey HSD post hoc tests. The research findings indicate that students' overall mathematical proof abilities fall into the low category, with an average score of 41.67 (on a scale of 100). From these results, 84% of the respondents are in the low category, 13% in the medium category, and 3% in the high category. Furthermore, when considering the backgrounds of secondary schools MA, SMK, and SMA, the average scores for mathematical proof abilities in all three groups are in the low category. The one-way ANOVA and Tukey HSD post hoc tests reveal a significant difference in mathematical proof abilities between the MA and SMA groups, while there was no significant difference between the MA and SMK groups or the SMK and SMA groups
KEMAMPUAN NUMERASI AND NEWMAN PROCEDURE: ANALISIS KESALAHAN MAHASISWA CALON GURU SD DALAM MENYELESAIKAN MASALAH MATEMATIKA
Authors: Nurmawanti Iva , Rahmatul Hidayati Vivi , Ramdhani Putri Hikmah , Sari Mega Puspita
Published: January 2024

Numeracy is an essential skill that must be possessed to be successful in the 21st century. Numeration contains complex problems that link mathematics to everyday life. It is necessary to know the numeracy abilities of prospective elementary school teacher students as an initial effort to develop the numeracy abilities of future elementary school teachers. Apart from that, knowing what errors arise in solving numeracy questions is necessary to know what actions to use to develop the numeracy of prospective elementary school teachers. One theory that can be used to see student errors in solving numeracy questions is based on Newman's Errors Analysis (NEA). This research used a qualitative approach involving 154 students, of which 124 experienced errors. The research results showed that there were student errors in Reading Errors (R) at 9.68%, Comprehension Errors (C) at 27.42%, Transformation Errors (T) at 22.58%, Process Skills Errors (P) at 35, 48%, and Encoding Errors (E) of 4.84%. These errors are caused by students not being able to understand the basic concept of fractions, incorrect conceptual understanding regarding the concept of fractions, and students not understanding how to write fraction symbols and what two fractions have in common