bluuebunny/crossref_metadata_2025 huggingface dataset:
Rate of clinically significant prostate cancer on repeat saturation biopsy after a diagnosis of atypical small acinar proliferation
Authors: Totaro Angelo , Di Gianfrancesco Luca , Pinto Francesco , Racioppi Marco , Palermo Giuseppe , Campetella Marco , Santoro Agostino Antonio , Arbia Giuseppe , Sacco Emilio
Published: February 2021

Background:

Atypical small acinar proliferation (ASAP) occurs in approximately 5% of prostate biopsies. Approximately 30%–40% of these patients may develop prostate cancer (PCa) within a 5-year period, often not clinically significant. Current guidelines recommend a repeat biopsy within 3–6 months after the initial diagnosis, but it seem not to be the best strategy.

Methods:

Objectives—evaluating the natural history of ASAP, stratifying the risk of csPCa after ASAP, identifying predictive factors of PCa after atypical diagnosis. Materials and methods—retrospective single-institutional study on patients undergoing prostate biopsy for suspicious PCa (2005–2016). We evaluated the incidence of overall PCa, intermediate-high risk of PCa and csPCa in case of ASAP, according to D’Amico classification and Epstein modified criteria.

Results:

Out of 4.567 patients undergoing prostate biopsy, ASAP was detected in 2.6% of cases. All patients with ASAP underwent repeat saturation biopsy within 6 months and PCa was diagnosed in 34.5%. According to D’Amico classification, 26%, 5.9%, and 2.5% had low, intermediate, and high-risk disease, respectively. According modified Epstein criteria, the incidence of csPCa was 12.6%. LRT showed that the overall probability to develop PCa doubled when PSA density (PSAD) moved from values lower than 0.13 ng/ml/cc to class 0.13–0.30 ng/ml/cc, and it tripled when PSAD was higher than 0.30 ng/ml/cc.

Conclusions:

The rate of csPCa in patients with an initial diagnosis of ASAP who had repeat biopsy was 12.6%. The overall PCa rate was 34.5%. Among patient undergoing RP, an upgrading from ncsPCa to csPCa was reported in 35% of cases. PSAD is the only predictive factor directly associated to the risk of developing PCa on repeat biopsy. These ﬁndings suggest that immediate repeat biopsy remains the correct strategy in absence of novel predictor factors and non-invasive diagnostic evaluations.
Identifying Interventions and Their Efficacy as Used by a Community Agency Managing and Responding to Elder Abuse
Authors: Storey Jennifer E. , Hart Samantha , Perka Melanie R.
Published: February 2021

Limited research has been conducted to identify how elder abuse (EA) can be managed and prevented. Interventions employed by a community agency multidisciplinary team across 164 EA cases were examined. Results identified the largest number ( N = 369) and widest variety of EA interventions to date. Using content analysis, interventions with similar proximal goals were grouped into 30 intervention strategies to evaluate efficacy and 12 higher-order intervention categories to guide practice. Intervention outcomes were rated as positive, negative, neutral, could not implement, or unknown. Positive outcomes were the most common (35%), and also included novel and/or effective interventions aimed at perpetrators such as physical treatment, social support, and communication. Few (1%) interventions had negative outcomes. Many interventions could not be implemented (21%), often due to a lack of funding or victim refusal. Results suggest changes to policy, practice, and research methodology, which could increase positive outcomes through facilitation of intervention implementation and improved data access.
Postmortem Analyses in a Patient With Succinic Semialdehyde Dehydrogenase Deficiency (SSADHD): II. Histological, Lipid, and Gene Expression Outcomes in Regional Brain Tissue
Authors: Walters Dana C. , Lawrence Regan , Kirby Trevor , Ahrendsen Jared T. , Anderson Matthew P. , Roullet Jean-Baptiste , Murphy Eric J. , Gibson K. Michael ,   the SSADH Deficiency Investigators Consortium (SDIC)
Published: February 2021

This study has extended previous metabolic measures in postmortem tissues (frontal and parietal lobes, pons, cerebellum, hippocampus, and cerebral cortex) obtained from a 37-year-old male patient with succinic semialdehyde dehydrogenase deficiency (SSADHD) who expired from SUDEP (sudden unexplained death in epilepsy). Histopathologic characterization of fixed cortex and hippocampus revealed mild to moderate astrogliosis, especially in white matter. Analysis of total phospholipid mass in all sections of the patient revealed a 61% increase in cortex and 51% decrease in hippocampus as compared to (n = 2-4) approximately age-matched controls. Examination of mass and molar composition of major phospholipid classes showed decreases in phospholipids enriched in myelin, such as phosphatidylserine, sphingomyelin, and ethanolamine plasmalogen. Evaluation of gene expression (RT2 Profiler PCR Arrays, GABA, glutamate; Qiagen) revealed dysregulation in 14/15 GABAA receptor subunits in cerebellum, parietal, and frontal lobes with the most significant downregulation in ∊, θ, ρ1, and ρ2 subunits (7.7-9.9-fold). GABAB receptor subunits were largely unaffected, as were ionotropic glutamate receptors. The metabotropic glutamate receptor 6 was consistently downregulated (maximum 5.9-fold) as was the neurotransmitter transporter (GABA), member 13 (maximum 7.3-fold). For other genes, consistent dysregulation was seen for interleukin 1β (maximum downregulation 9.9-fold) and synuclein α (maximal upregulation 6.5-fold). Our data provide unique insight into SSADHD brain function, confirming astrogliosis and lipid abnormalities previously observed in the null mouse model while highlighting long-term effects on GABAergic/glutamatergic gene expression in this disorder.
Miller Fisher Syndrome Triggered by Infections: A Review of the Literature and a Case Report
Authors: Spyromitrou-Xioufi Panagiota , Ntoulios Georgios , Ladomenou Fani , Niotakis Georgios , Tritou Ioanna , Vlachaki Georgia
Published: February 2021

Aim:

We reported a case of Miller Fisher syndrome following a breakthrough varicella zoster virus infection in an otherwise healthy 6-year-old male. The objective of this review was to summarize the infectious etiologic agents known to trigger Miller Fisher syndrome.

Methods:

Review of the literature on infections associated with Miller Fisher syndrome.

Results:

We identified 762 studies after duplicates were removed. Titles, abstracts, and full texts were screened. Finally, 37 studies were included in qualitative synthesis after citations and reference list were checked. The age range of cases reported was 0-78 years, and male sex was predominant in studies where these parameters were reported. The most common causative agent was Campylobacter jejuni followed by Haemophilus influenzae.

Conclusions:

Our review highlights the importance of recognizing the infections triggering Miller Fisher syndrome. We also present a unique case of Miller Fisher syndrome associated with breakthrough varicella zoster virus infection. Preventive policies may consider population immunization for certain causative agents.
Low Self-control and School Bullying: Testing the GTC in Nigerian Sample of Middle School Students
Authors: Fenny Omobolanle Atinuke
Published: February 2021

Gottfredson and Hirschi’s General Theory of Crime’s (GTC) claim to explain crime, at all times, and in all places, has received considerable empirical support using Western, Scandinavian, and Asian samples. However, the theory is yet to be tested using a Nigerian sample. Using cross-sectional data from a sample of 1,192 junior secondary school (middle school) students in Nigeria, this study examines the explanatory power of Gottfredson and Hirschi’s GTC in predicting bullying perpetration and victimization in that context and culture. Binomial logistic regression was used to test the hypothesis that the bullying perpetration and victimization experiences of these students would be negatively related to self-control. Study provides support for the cross-cultural potency of the GTC as low self-control predicted the bullying and victimization experiences of these students regardless of gender. Students’ perception of a negative school environment was also a significant predictor of bullying. This is the first test of the GTC with a Nigerian sample and hopefully, will be a springboard for effective bullying prevention policy/programs in Nigerian schools. The public policy implications of the findings are discussed.
What teachers and parents can add to personality ratings of children: Unique associations with academic performance in elementary school
Authors: Brandt Naemi D , Becker Michael , Tetzner Julia , Brunner Martin , Kuhl Poldi
Published: February 2021

Adults’ ratings of children’s personality have been found to be more closely associated with academic performance than children’s self-reports. However, less is known about the relevance of the unique perspectives held by specific adult observers such as teachers and parents for explaining variance in academic performance. In this study, we applied bifactor (S–1) models for 1411 elementary school children to investigate the relative merits of teacher and parent ratings of children’s personalities for academic performance above and beyond the children’s self-reports. We examined these associations using standardized achievement test scores in addition to grades. We found that teachers’ unique views on children’s openness and conscientiousness had the strongest associations with academic performance. Parents’ unique views on children’s neuroticism showed incremental associations above teacher ratings or self-reports. For extraversion and agreeableness, however, children’s self-reports were more strongly associated with academic performance than teacher or parent ratings. These results highlight the differential value of using multiple informants when explaining academic performance with personality traits.
Resistant Transparency and Nonprofit Labor: Challenging Precarity in the Art + Museum Wage Transparency Campaign
Authors: Südkamp Carolin M. , Dempsey Sarah E.
Published: February 2021

Drawing upon contemporary academic debates about nonprofit worker precarity combined with needed theoretical re-orientations toward transparency, this paper explicates the situated communication practices and politics of resistant transparency. Resistant transparency describes communication aimed at revealing and publicizing previously obscured or hidden wage data and employment conditions to challenge powerful actors. Resistant transparency involves dynamic shifts in control over information, modes of in/visibility, and surveillance of powerful actors. We develop the case of Art + Museum Transparency, a collective of arts and museum workers employing Google spreadsheets and Twitter to publicize salary information and challenge norms of self-sacrifice and unpaid labor. Moving beyond an understanding of transparency as an institutional demand, our analysis develops how technical affordances shaped the collective’s efforts. We argue that transparency functions as a resistant communicative practice with potential for increasing worker voice and furthering the goals of collective resistance to precarious work across sites of employment.
Are Girls More Ambitious Than Boys? Vocational Interests Partly Explain Gender Differences in Occupational Aspirations
Authors: Wicht Alexandra , Miyamoto Ai , Lechner Clemens M.
Published: February 2021

Previous research suggests that girls have higher occupational aspirations than boys before entering the labor market. We investigate whether this gender gap in occupational aspirations generalizes to secondary school students in Germany and illuminate the possible mechanisms behind these purported gender differences. For this purpose, we used a large and representative sample of ninth graders ( N = 10,743) from the German National Educational Panel Study. Adolescents’ occupational aspirations were coded on the International Socio-Economic Index of Occupational Status (ISEI) according to the socioeconomic status of the aspired occupation. Results showed that girls’ occupational aspirations were 6.5 ISEI points higher than boys’ (Cohen’s d = .36). Mediation analyses further revealed that gender differences in vocational interest could explain one-half of the gender gap in occupational aspirations. This suggests that girls’ higher occupational aspirations reflect their specific vocational interests rather than a general striving for higher status and prestige compared to boys.
Pharmacokinetics of culture-directed antibiotics for the treatment of peritonitis in automated peritoneal dialysis: A systematic narrative review
Authors: Ling Chau Wei , Sud Kamal , Van Connie , Zaidi Syed Tabish Razi , Patel Rahul P. , Peterson Gregory M. , Castelino Ronald L.
Published: February 2021

The objectives of this study were to provide a summary of the pharmacokinetic data of some intraperitoneal (IP) antibiotics that could be used for both empirical and culture-directed therapy, as per the ISPD recommendations, and examine factors to consider when using IP antibiotics for the management of automated peritoneal dialysis (APD)-associated peritonitis. A literature search of PubMed, EMBASE, Scopus, MEDLINE and Google Scholar for articles published between 1998 and 2020 was conducted. To be eligible, articles had to describe the use of antibiotics via the IP route in adult patients ≥18 years old on APD in the context of pharmacokinetic studies or case reports/series. Articles describing the use of IP antibiotics that had been recently reviewed (cefazolin, vancomycin, gentamicin and ceftazidime) or administered for non-APD-associated peritonitis were excluded. A total of 1119 articles were identified, of which 983 abstracts were screened. Seventy-three full-text articles were assessed for eligibility. Eight records were included in the final study. Three reports had pharmacokinetic data in patients on APD without peritonitis. Each of cefepime 15 mg/kg IP, meropenem 0.5 g IP and fosfomycin 4 g IP given in single doses achieved drug plasma concentrations above the minimum inhibitory concentration for treating the susceptible organisms. The remaining five records were case series or reports in patients on APD with peritonitis. While pharmacokinetic data support intermittent cefepime 15 mg/kg IP daily, only meropenem 0.5 g IP and fosfomycin 4 g IP are likely to be effective if given in APD exchanges with dwell times of 15 h. Higher doses may be required in APD with shorter dwell times. Information on therapeutic efficacy was derived from case reports/series in individual patients and without therapeutic drug monitoring. Until more pharmacokinetic data are available on these antibiotics, it would be prudent to shift patients who develop peritonitis on APD to continuous ambulatory peritoneal dialysis, where pharmacokinetic information is more readily available.
The prevalence of human leucocyte antigen and human papillomavirus DNA in penile intraepithelial neoplasia in England 2011–2012
Authors: Shim Tang Ngee , Harwood Catherine A , Marsh Steven GE , Gotch Frances M , Quint Wim , de Koning Maurits N , Francis Nick , Jameson Charles , Freeman Alex , Minhas Suks , Muneer Asif , Dinneen Michael , Bunker Christopher B
Published: February 2021

Background: The pathogenesis of penile intraepithelial neoplasia (PeIN) is unclear but human papillomavirus (HPV) infection and polymorphisms in human leucocyte antigen (HLA). Objectives: To examine the prevalence of HPV DNA and HLA in PeIN. Methods: Adult Caucasian men with a clinical and histological diagnosis of PeIN, that is, Bowenoid papulosis (BP), Bowen’s disease of penis (BDP) and erythroplasia of Queyrat (EQ) were selected and phenotyped from the clinical records. DNA was extracted from blood and paraffin-embedded sections for HLA and HPV typing, respectively. Human leucocyte antigen allele frequencies were compared with those derived from the UK–based Caucasian population. Results: Seventy-two cases of PeIN (20 BP, 34 BDP and 18 EQ) were studied. Human papillomavirus DNA was identified in 65/72 (90.2%) PeIN; Alphapapillomavirus types were detected in 62/72 (85%) followed by Betapapillomavirus types in 9/72 (12.5%) and cutaneous types in 7/72 (9.7%); HPV16 was the most prevalent genotype at 35/72 (48.6%) followed by HPV33 at 7/72 (9.7%); multiple infections were seen in 18/72 (25%) PeIN. HLA-C*15 (Bonferroni corrected p = 0.049) confers susceptibility to PeIN, whereas HLA-DQA1*01 (corrected p = 0.02) protects against PeIN. HPV16-associated PeIN cases showed no statistically significant association with HLA genotype after multiple corrections. Conclusion: Human papillomavirus is involved in the pathogenesis of PeIN. Immunogenotype may play a role in the pathogenesis of PeIN.
Comparison of methods for the detection of Neisseria gonorrhoeae from South African women attending antenatal care
Authors: Oree Glynis , Naicker Meleshni , Maise Hopolang C , Tinarwo Partson , Ramsuran Veron , Abbai Nathlee S
Published: February 2021

The detection of Neisseria gonorrhoeae using culture assays is challenging. This study aims to compare different assays for the detection of N. gonorrhoeae. This cross-sectional study was conducted at King Edward VIII Hospital and included 307 antenatal attendees, each willing to provide two endocervical swabs. The first swab was used for culture identification of N. gonorrhoeae, and the second swab was processed for the detection of the pathogen by the TaqMan quantitative polymerase chain reaction (qPCR) assay, an in-house 16S ribosomal RNA ( rRNA) PCR and PCR detection of the opa gene. Culture and the nucleic acid amplification assays were each used as comparator tests in the analysis. Sensitivity and specificity were calculated using RS Studio. The prevalence of N. gonorrhoeae was 7.8%. When compared to the TaqMan assay, the 16S rRNA PCR exhibited the highest sensitivity of 62%, with a substantial level of agreement (kappa level of agreement: 0.60), followed by the opa PCR (38%) with a moderate level of agreement (0.52) and culture exhibiting the lowest sensitivity of 25% with a fair level of agreement (0.38). The diagnostic accuracy of all the assays was >90%. The TaqMan qPCR assay has the ability to serve as a future diagnostic assay for the detection of N. gonorrhoeae.
Factors associated with HIV care and treatment cascade in Rio Grande do Sul, Brazil, 2014–2017: A cross-sectional study
Authors: Shimocomaqui Guilherme B , Meyer Craig S , Ikeda Maria L , Romeu Farias Elson , Gonçalves Tonantzin R , Rutherford George W , Tregnago Barcellos Nêmora
Published: February 2021

In 2018, Rio Grande do Sul (RS) had some of the highest HIV/AIDS rates in Brazil, and we did not find any studies about the HIV care and treatment cascade (HCTC) related to this state. We aimed to estimate the indicators of HCTC of RS, Brazil, and associated factors. A cross-sectional study with all people living with HIV (PLWH) in RS between 1 January 2014 and 31 December 2017 was conducted using a national database which registers all HIV notifications, CD4 and viral load laboratory data and antiretroviral therapy (ART) usage in the public health system. We considered sex, age, education, race, year of HIV diagnosis, and health region as predictor factors, and defined linkage to care, retention to care, being on ART, and having undetectable viral load as the HCTC indicators. Descriptive analysis and multivariable logistic regression were performed using Stata 15.2. A total of 116,121 PLWH were diagnosed, 79,959 were linked to care, 72,117 retained in care, 69,219 on ART, and 54,857 had undetectable viral load from 2014 to 2017. We observed greatest attrition for younger age, non-white, and lower education in all HCTC indicators. Women are more likely to have undetectable viral load (OR = 1.04, 95% CI: 1.01–1.07), even though they are less likely to be retained to care (OR = 0.92; 95% CI: 0.89–0.96) and on ART (OR = 0.82; 95% CI: 0.78–0.86). Although all HCTC indicators have increased over the period and the “test and treat” policy indicates improvements in ART and in undetectable viral load outcomes, evidence suggests specific attrition and disparities such as those related to HIV healthcare facilities should be addressed. These findings may be used by researchers, health professionals, and policymakers in order to investigate and implement interventions to better engage PLWH across the HCTC.
Twin Differences in Harsh Parenting Predict Youth’s Antisocial Behavior
Authors: Burt S. Alexandra , Clark D. Angus , Gershoff Elizabeth T. , Klump Kelly L. , Hyde Luke W.
Published: February 2021

In the current study, we leveraged differences within twin pairs to examine whether harsh parenting is associated with children’s antisocial behavior via environmental (vs. genetic) transmission. We examined two independent samples from the Michigan State University Twin Registry. Our primary sample contained 1,030 families (2,060 twin children; 49% female; 6–10 years old) oversampled for exposure to disadvantage. Our replication sample included 240 families (480 twin children; 50% female; 6–15 years old). Co-twin control analyses were conducted using a specification-curve framework, an exhaustive modeling approach in which all reasonable analytic specifications of the data are interrogated. Results revealed that, regardless of zygosity, the twin experiencing harsher parenting exhibited more antisocial behavior. These effects were robust across multiple operationalizations and informant reports of both harsh parenting and antisocial behavior with only a few exceptions. Results indicate that the association between harsh parenting and children’s antisocial behavior is, to a large degree, environmental in origin.
MicroRNA-26b-5p alleviates cerebral ischemia-reperfusion injury in rats via inhibiting the N-myc/PTEN axis by downregulating KLF10 expression
Authors: Xiao Y , Zheng S , Duan N , Li X , Wen J
Published: February 2021

MicroRNAs plays important role in cerebral ischemia-reperfusion (CIR). However, the role of miR-26b-5p in CIR injury remains unclear. PC12 cells were treated with oxygen-glucose deprivation (OGD) for 0 h, 2 h, 4 h, 6 h, and then reoxygenated for 24 h to construct an in vitro I/R model. Then, miR-26b-5p mimic, small interfering RNA of KLF10 and KLF10 overexpression plasmid were transfected into cells respectively for mechanism study. Our results showed that miR-26b-5p was downregulated in OGD/R-induced PC12 cells. After overexpression of miR-26b-5p, cell proliferation ability was enhanced, apoptosis, ROS and inflammatory mediators were inhibited. Bioinformatics analysis indicated that miR-26b-5p was directly bound to the 3’ UTR of KLF10, and downregulated the expression of KLF10. KLF10 was upregulated in OGD/R cells, and transfection with si-KLF10 promoted cell proliferation and reduced apoptosis, NO concentration and inflammatory factor secretion. Moreover, pcDNA-KLF10 reversed the inhibitory effects of miR-26b-5p mimic on apoptosis, NO content and inflammatory factor secretion, as well as the downregulation of N-myc and PTEN expression. Meanwhile, I/R rat models were constructed and divided into sham operation group (femoral artery isolation only), model group (middle cerebral artery occlusion model of rats was prepared by thread embolization), treatment group (200 µL of miR-26b-5p mimic was injected into the brain of model rats). We observed that the infarct size of brain tissue was reduced, KLF10 expression was downregulated, and apoptosis and inflammatory response were reduced. These results suggest that miR-26b-5p had protective effects on CIRI and it may be a potential treatment target.
Renoprotective effects of prazosin on ischemia-reperfusion injury in rats
Authors: Rahimi MM , Bagheri A , Bagheri Y , Fathi E , Bagheri S , Nia AV , Jafari S , Montazersaheb S
Published: February 2021

Background:

Renal ischemia-reperfusion (IR) injury is one of the main leading causes of acute kidney injury associated with inflammation, oxidative stress and cell apoptosis. We studied the effects of prazosin, as a specific blocker of α1-AR, on renal IR injury.

Methods:

Rats were divided into normal control; untreated IR and prazosin-treated IR (1 mg/kg body weight). Prazosin was administered by intraperitoneal injection 30 min prior to IR induction. The level of urea/creatinine and oxidative factors were detected by colorimetric methods. Apoptosis-associated factors, inflammatory, and signaling proteins were analyzed in renal tissue. The abnormalities of renal histopathology were detected by immunohistochemistry.

Results:

Administration of prazosin to IR rats ameliorated serum urea and creatinine and IR-induced histopathological damages. Lipid peroxidation was significantly improved after treatment by prazosin in IR injury rats, however, antioxidant status was not affected. Rats subjected to IR injury activated Bax protein and NF-κB mediated inflammatory response. Moreover, treatment with prazosin inhibited renal NF-κB activation, resulting in a significant decline in pro-inflammatory cytokine of IL-6.

Conclusion:

These findings suggest that prazosin could be a good candidate to attenuate renal IR injury due to its ability to modulate renal function, apoptosis and inflammation.
CircRNA Circ-ITCH Inhibits the Proliferation and Invasion of Glioma Cells Through Targeting the miR-106a-5p/SASH1 Axis
Authors: Chen Wei , Wu Ming , Cui Si-Tong , Zheng Yue , Liu Zhen , Luo Liang-Sheng
Published: February 2021

Circ-ITCH, a novel circRNA, was generated from several exons of itchy E3 ubiquitin protein ligase (ITCH). Recently, circ-ITCH has been demonstrated to be involved in cancer development. However, there have been few investigations on the specific role of circ-ITCH in glioma. In this study, we performed quantitative real-time polymerase chain reaction analysis and identified that circ-ITCH was significantly downregulated in glioma tissues and cell lines. The function assays showed that upregulation of circ-ITCH inhibited glioma cell proliferation and invasion in vitro as well as reduced cell growth in vivo. Moreover, miR-106a-5p was found serving as a target of circ-ITCH and miR-106a-5p mimics could reverse the inhibitory effect of circ-ITCH on glioma cell proliferation and invasion. We also revealed that circ-ITCH increased SASH1 expression by sponging miR-106a-5p in glioma cells. In addition, SASH1 downregulation could abrogate the suppressive effect of circ-ITCH on glioma progression. Taken together, our results suggested that circ-ITCH could suppress glioma cell proliferation and invasion via regulating the miR-106a-5p/SASH1 axis, elucidating a novel molecular target for glioma treatment.
Stem Cell Therapy for Spinal Cord Injury
Authors: Huang Liyi , Fu Chenying , Xiong Feng , He Chengqi , Wei Quan
Published: February 2021

Traumatic spinal cord injury (SCI) results in direct and indirect damage to neural tissues, which results in motor and sensory dysfunction, dystonia, and pathological reflex that ultimately lead to paraplegia or tetraplegia. A loss of cells, axon regeneration failure, and time-sensitive pathophysiology make tissue repair difficult. Despite various medical developments, there are currently no effective regenerative treatments. Stem cell therapy is a promising treatment for SCI due to its multiple targets and reactivity benefits. The present review focuses on SCI stem cell therapy, including bone marrow mesenchymal stem cells, umbilical mesenchymal stem cells, adipose-derived mesenchymal stem cells, neural stem cells, neural progenitor cells, embryonic stem cells, induced pluripotent stem cells, and extracellular vesicles. Each cell type targets certain features of SCI pathology and shows therapeutic effects via cell replacement, nutritional support, scaffolds, and immunomodulation mechanisms. However, many preclinical studies and a growing number of clinical trials found that single-cell treatments had only limited benefits for SCI. SCI damage is multifaceted, and there is a growing consensus that a combined treatment is needed.
Impact of cancer screening on metastasis: A prostate cancer case study
Authors: Lange Jane , Remmers Sebastiaan , Gulati Roman , Bill-Axelson Anna , Johansson Jan-Erik , Kwiatkowski Maciej , Auvinen Anssi , Hugosson Jonas , Hu Jim C , Roobol Monique J , Carlsson Sigrid V , Etzioni Ruth
Published: February 2021

Background

Trials of cancer screening present results in terms of deaths prevented, but metastasis is also a key endpoint that screening seeks to prevent. We developed a framework for projecting overall (de novo and progressive) metastases prevented in a screening trial using prostate cancer screening as a case study.

Methods

Mechanistic simulation model in which screening shifts a fraction of cases that would be metastatic at diagnosis to being non-metastatic. This shift increases the incidence of non-overdiagnosed, organ-confined cases. We use estimates of the risk of metastatic progression for these cases to project how many progress to metastasis after diagnosis and tally the projected de novo and progressive metastatic cases with and without screening. We use data on stage shift from the European Randomized Study of Screening for Prostate Cancer (ERSPC) and data on the risk of metastatic progression from the Scandinavian Prostate Cancer Group-4 trial. We estimate the relative risk and absolute risk reductions in metastatic disease at diagnosis and compare these with reductions in overall metastases.

Results

Assuming no effect of screening beyond initial stage shift at diagnosis, the model projects a 43% reduction in metastasis at diagnosis but a 22% reduction in the cumulative probability of metastasis over 12 years in favor of screening. These results are consistent with the empirical findings from the ERSPC.

Conclusion

Any reduction in metastatic disease at diagnosis under screening is likely to be an overly optimistic predictor of the impact of screening on overall metastasis and disease-specific mortality.
Hybrid capture 2 and cobas® 4800: Comparison of performance of two clinically validated tests for human papillomavirus primary screening of cervical cancer
Authors: Mongia A , Pompeo G , Sani C , Burroni E , Fantacci G , Bisanzi S , Cellai F , Ventura L , Bottari F , Carozzi F
Published: February 2021

Objective

To compare, in a primary human papillomavirus screening setting, two different validated human papillomavirus tests, considering their analytical and clinical screening performances.

Methods

In Tuscany, a human papillomavirus screening program was implemented in 2013. Hybrid capture 2 (Qiagen) was used for testing until May 2016, when it was replaced by the cobas® 4800 human papillomavirus test (Cobas; Roche). We evaluated the performance of Hybrid capture 2 and Cobas on: the same screening population in two different periods (before and after changing to Cobas); the same Hybrid capture 2-positive consecutive samples. Discordant samples (Hybrid capture 2-positive/Cobas negative) were typed on the L1 gene (reverse line blot, AB Analitica) and E6/E7 genes (BD Onclarity assay).

Results

In the considered time period ( n = 37,775), human papillomavirus positivity was 9.8% and 7.4%, respectively, for Hybrid capture 2 and Cobas ( p < 0.0001). At immediate colposcopy, the cervical intraepithelial neoplasia, grade 2 positive predictive value was, respectively, 23.8% and 34% ( p < 0.001). At one-year recall, human papillomavirus persistence was, respectively, 40.6% and 62.2% ( p < 0.0001). Of Hybrid capture 2-positive re-tested samples ( n = 620), 32.4% were Cobas negative. Of discordant samples typed on L1, 7% were positive for the 12 high-risk human papillomavirus. Of the samples found to be negative for the 12 high-risk human papillomavirus types on L1, 14.5% were positive on E6/E7 typing. Among the discordant samples, the only two cervical intraepithelial neoplasia (CIN) grade 3 lesions were non-high-risk human papillomavirus positive on both L1 and E6/E7 typing.

Conclusion

At baseline, Hybrid capture 2 showed greater human papillomavirus positivity and a lower CIN2+ positive predictive value than Cobas, which was more specific than Hybrid capture 2 in detection of high-risk human papillomavirus: 80% of discordant samples were confirmed as high-risk human papillomavirus negative. This higher analytical specificity determined the non-identification of two CIN3 lesions.
Internationalization of Chinese Higher Education: Is It Westernization?
Authors: Guo Yan , Guo Shibao , Yochim Lorin , Liu Xiaoli
Published: February 2021

Internationalization has become a strategic policy priority for many Chinese higher education in the process of becoming world-class universities. However, there is little research focusing on students’ experiences of internationalization at home. This research investigates how Chinese undergraduates interpreted and experienced internationalization at a prestigious university in China. Data for the study were collected through policy document analysis, semi-structured interviews with students, and site visits. The results of the study reveal that students perceive internationalization as Westernization, question the prominence of English in the university’s internationalization in both formal and informal curricula, and raise concerns about unequal access to internationalization. The study interrogates the unidirectional orientation of internationalization between China and the developed Western world. It calls for an approach to the de-Westernization of internationalization, reclaiming indigenous Chinese epistemology, language, and culture. The findings have important implications for an alternative social imaginary of internationalization for researchers and policymakers.
International Student Mobility Aspirations: The Role of Romantic Relationships and Academic Motivation
Authors: De Winter Tom , Van Mol Christof , de Valk Helga A. G.
Published: February 2021

The academic literature on the determinants of international student mobility so far has largely ignored the influence of romantic relationships and study motivation in the development of aspirations to participate in temporary learning experiences in another country. However, young adults might take considerations about investments in individual development (via academic training and thus study motivation) and romantic relationships into account in their decision-making process. Consequently, we apply a life-course perspective analyzing the relationships between having a romantic partner, study motivation, and aspirations to participate in an international exchange program among first-year university students, based on a survey conducted among 603 freshmen in Brussels. As female students are more likely to participate in student exchanges compared with male students, we pay special attention to gender differences. Our results show that a romantic relationship is negatively correlated with aspirations to participate in an international student exchange among female students. In contrast, intrinsic academic motivation is significantly associated with such aspirations among female and male students. Overall, our findings indicate the need for the consideration of different life-course domains in academic studies on international student mobility.
University Teaching in Global Times: Perspectives of Italian University Faculty on Teaching International Graduate Students
Authors: Coryell Joellen E. , Cinque Maria , Fedeli Monica , Lapina Salazar Angelina , Tino Concetta
Published: February 2021

Recently, many Italian universities began offering graduate courses or entire programs in English to attract international students, assist domestic students with English language proficiency, and internationalize the learning experience for all. This research investigated Italian faculty’s perspectives on their experiences of teaching international graduate students. The article begins with an overview of European university internationalization and then reviews the literature on faculty perspectives on teaching international students and instructional professional development for internationalization of teaching and learning. Findings include participant demographics and faculty perspectives on teaching international graduate students as compared with domestic students, their current and desired ways of learning how to teach international students, and their recommendations for faculty teaching in international programs/courses with English as the language of instruction. Implications for instructional professional development, communities of instructional practice, and further research are offered.
Illusory freedom of physical platform workers: Insights from Uber Eats in Japan
Authors: Umer Hamza
Published: February 2021

Platform work is often advocated as offering freedom of work to labour. Contesting this claim, this article undertakes a comparative analysis of the pros and cons of food delivery platform work prior to and during the COVID-19 pandemic, and argues that the freedom of food delivery platform workers is essentially an ‘illusory freedom’. In reality, platform work has only changed mechanisms through which companies can exercise control over labour and evade their employer obligations. As a case, the article examines the illusory freedom of food delivery platform workers associated to Uber Eats in Japan. The collective bargaining efforts of food delivery workers against the excessive control of Uber Eats and the extent of success of these efforts are also examined. The article concludes by discussing the possible factors that have undermined the effectiveness of the collective bargaining efforts of the labour union.
Networked Teaching: Overcoming the Barriers to Teaching Experiential Learning in Large Classes
Authors: Mantai Lilia , Huber Elaine
Published: February 2021

As student enrolments grow and student diversity increases in many areas of higher education, faculty face challenges to support and ensure individual student learning and development. At the same time, active and experiential approaches to learning are recognized for their potential to develop autonomy and critical thinking, among other valuable skills. However, such approaches are challenging to implement at scale and alter the educator’s role from a directive one to a more facilitating role. This article reports on a questionnaire with 66 business academics at a large Australian metropolitan university that examined teaching experiences at scale and identified perceived barriers and enablers of experiential learning in large classes. Academics reported their lived experiences of teaching at scale and revealed the need to recognize teaching practice as a highly networked and distributed activity. In experiential learning, and particularly in large classes, the locus of control for learning shifts to the student, leading to feelings of disorientation and disempowerment. We make several recommendations for teaching development, faculty, and future research.
Black Male School Leaders: Protectors and Defenders of Children, Community, Culture, and Village
Authors: Smith Phillip A.
Published: February 2021

This study explored the ways in which the race-gendered identities and lived experiences of Black male K-12 public and independent school leaders inform their leadership in support of students, community, and village. The study draws from critical theories and perspectives, including a framework of Black Masculine Caring (BMC), critical race theory, culturally relevant and responsive leadership, leadership for social justice, and their relationship to and with a theory of Black male school leadership. The qualitative study used survey, phenomenological, and visual elicitation methods to examine the personal and professional experiences, philosophies, and praxis of 14 Black male school leaders. Study findings are presented as an intergenerational dialog with participants, based on their years of leadership experience. These leaders exhibit a liberatory care-based approach to leadership as an expression of social justice advocacy, civil rights activism, community and evidenced action-orientated commitment to a dismantling of structured and systemic forms of racism, anti-Black racism entrenched segregation, and other inequities that discriminate and disproportionately marginalize significant numbers of students and their communities. As captured through the narratives shared, this is evidenced through greater, and positively encouraged, levels of parental and other community member involvement in school activities, as a core aspect of the leadership and decision-making processes. The research expands understanding of paradigms of critical race leadership and disrupts the normative educational leadership that ill-serve significant sections of our student populations and communities.
Masticatory Function Assessment of Adult Patients With Cleft Lip and Palate After Orthodontic Treatment
Authors: Miura Sayumi , Ueda Hiroshi , Iwai Koji , Concepcion Medina Cynthia , Ishida Eri , Kunimatsu Ryo , Tanimoto Kotaro
Published: February 2021

Objective:

To determine whether orthodontically treated patients with cleft lip and palate (CLP) possess a different masticatory function than those of untreated patients with normal occlusion.

Design:

Occlusal contact area, occlusal force, as well as masseter and anterior temporal muscular activity were measured during maximum voluntary clenching (MVC) tests. Mandibular left and right lateral movements during mastication were also assessed. To further elucidate the nature of masticatory function, especially to determine the rate of abnormal jaw movement patterns, a parametric error index (EI) was set. Finally, masticatory efficiency was evaluated with a glucose sensitive measuring device.

Participants:

Fifteen patients with CLP who had previously completed the orthodontic treatments required to achieve an acceptable and more harmonious occlusion accepted to volunteer in this study along with 21 untreated patients who already possessed a normal occlusion.

Results:

Patients with CLP showed a significantly lower occlusal force, reduced occlusal contact area, and decreased masticatory efficiency as well as significantly higher EI value when compared with controls. However, there was no significant difference when analyzing muscle activity, although masticatory efficiency was significantly different between the 2 groups. Despite this result, the scores obtained by the patients with CLP in the masticatory efficiency tests were still in the normal range.

Conclusions:

Orthodontic treatment for adult patients with CLP provides a satisfactory result for the patients’ masticatory ability albeit significantly less ideal compared with untreated patients with normal occlusion.
Experiences of School Nurses Caring for Newly Arrived Immigrant and Refugee Children
Authors: Brady Jacqueline A. , Underhill-Blazey Meghan L. , Burke Pamela J. , Lee Christina S. , Howard Elizabeth P. , Duffy Lisa V.
Published: February 2021

Newly arrived immigrant and refugee children are faced with significant physical and mental health issues and often rely on school nurses for care and connection to healthcare. The purpose of this qualitative phenomenological study was to explore urban public school nurses’ experiences caring for newly arrived children. Data were collected through one-time in-depth semistructured interviews with school nurses ( n = 20). Three relational themes were identified: (1) Trials and Triumphs: Telling Stories About Newly Arrived Children; (2) Walk a Mile in My Shoes; and, (3) Being a Trusted Health Navigator. The Role of School Nurses in the Context of Trauma emerged as the constitutive pattern. The current study enhances our understanding of the unique role played by school nurses as they address the profound needs of newly arrived children and their families, many of whom have survived trauma and face a number of barriers to accessing care.
Clinical Use of Cangrelor After Percutaneous Coronary Intervention in Patients Requiring Mechanical Circulatory Support
Authors: Katz Alyson , Lewis Tyler C. , Arnouk Serena , Altshuler Diana , Papadopoulos John , Toy Bridget , Smith Deane E. , Merchan Cristian
Published: February 2021

Background:

Patients with cardiogenic shock after percutaneous coronary intervention (PCI) may require mechanical circulatory support (MCS). The combination of dual antiplatelet therapy with cangrelor and continuous anticoagulation required for MCS may increase the risk of bleeding.

Objective:

The objective of the study is to describe the complications and outcomes of patients who received cangrelor during MCS following PCI.

Methods:

This is a single-center, retrospective, observational case series of 17 patients who received cangrelor while on MCS from June 2017 to September 2019.

Results:

In a case series of 17 patients, 8 patients (47%) were supported with an Impella device and 4 patients (24%) with venoarterial (VA) extracorporeal membrane oxygenation (ECMO); 5 required (29%) concomitant VA ECMO and Impella support in the setting of cardiogenic shock. All patients received triple antithrombotic therapy with aspirin, heparin, and cangrelor. Cangrelor was commonly initiated at a median dose of 0.75 (range 0.5-4) µg/kg/min. Cangrelor dose adjustments included changes in increments up to 0.25 µg/kg/min with review of P2Y12 levels. A total of 10 patients (59%) experienced a bleeding event, most commonly located at the peripheral cannulation site (40%) and in the gastrointestinal tract (30%). Seven (70%) and 3 (30%) of the bleeding complications were classified as major and minor, respectively. No patient developed in-stent thrombosis during the hospitalization; 14 (82%) patients survived their MCS course.

Conclusion and Relevance:

This case series suggests that cangrelor doses less than 0.75 µg/kg/min may be beneficial. Larger studies should evaluate alternative dosing regimens.
Human factors and aging: A 20-year retrospective and prospective from CREATE researchers
Authors: Rogers Wendy A. , Czaja Sara J. , Charness Neil , Boot Walter R. , Sharit Joseph
Published: February 2021

The Center for Research and Education on Aging and Technology Enhancement (CREATE) was founded in 1999 and is funded by the National Institute on Aging (National Institutes of Health; PO1 AG017211). This interdisciplinary team of psychologists and engineers focuses on design and deployment of technology with aging adults. In this panel session, we will provide an overview of CREATE research in the domains of health, leisure, work, and social engagement. We will discuss current and emerging technologies. CREATE research has provided insights about the needs and preferences of older adults; design requirements for successful technology support; the necessity of proper instruction and training; and the value of technology tools for all facets of life. This interdisciplinary collaboration has generated evidence-based guidelines for designing, training, and deploying technology to enhance quality of life. Time will be provided for general audience discussion regarding future directions and challenges for design of emerging technologies.
Team Interaction Strategies for Human–Autonomy Teaming in Next Generation Combat Vehicles
Authors: Lematta Glenn J. , Johnson Craig J. , Holder Eric , Huang Lixiao , Bhatti Shawaiz A. , Cooke Nancy J.
Published: February 2021

The current study focuses on improving team effectiveness in Next Generation Combat Vehicles (NGCVs) that combine humans, intelligent agents, and unmanned assets working together toward common goals, “teaming”, through the development of interaction strategies for this future contextual domain. Twenty interaction strategies were derived from three objectives to account for system changes anticipated from the introduction of NGCVs. In particular, consideration is given for improving awareness of team members, maintaining flexible coordination, and working within the constraints of the new environment. Future work should focus on validating the strategies and the implementation of strategies into NGCV design.