bluuebunny/crossref_metadata_2025 huggingface dataset:
Case series, chemotherapy-induced cardiomyopathy: mind the family history!
Authors: Moghadasi Setareh , Fijn Rienke , Beeres Saskia L M A , Bikker Hennie , Jongbloed Jan D H , Josephus Jitta Djike , Kroep Judith R , Lekanne Deprez Ronald H , Vos Yvonne J , de Vreede Mariëlle J M , Antoni M Louisa , Barge-Schaapveld Daniela Q C M
Published: September 2021

Background

Cardiotoxicity presenting as cardiomyopathy is a common side effect in cancer treatment especially with anthracyclines. The role of genetic predisposition is still being investigated.

Case summary

Four unrelated patients with a familial burden for cardiac disease, who developed cardiomyopathy after anthracycline treatment are presented. Case 1 received chemotherapy for breast cancer and developed a dilated left ventricle just after treatment. Her father had died unexpectedly while being screened for heart transplant. Case 2 was known with a family history of sudden cardiac death prior to her breast cancer diagnosis. She received anthracycline-containing chemotherapy treatment twice in 5 years due to recurrence of breast cancer. During that period, two brothers developed a cardiomyopathy. Eighteen years later, a genetic predisposition for cardiomyopathy was ascertained and at screening an asymptomatic non-ischaemic cardiomyopathy was established. Case 3 was diagnosed with a dilated cardiomyopathy 1 year after chemotherapy treatment for breast cancer. Her mother had developed a dilated cardiomyopathy several years before. Case 4 received chemotherapy treatment for Non-Hodgkin’s lymphoma and developed dilated cardiomyopathy 1 year later. His brother died from congestive heart failure which he developed after chemotherapy for Non-Hodgkin’s lymphoma and a grandmother had died suddenly during child delivery. In all four cases, genetic screening showed (likely) pathogenic variants in cardiomyopathy-associated genes.

Discussion

Current guidelines recommend cardiac evaluation in cancer patients receiving chemotherapy based on the presence of cardiovascular risk factors at the start of treatment. This series emphasizes the importance of including a thorough family history in this process.
Ticagrelor monotherapy in patients at high bleeding risk undergoing percutaneous coronary intervention: TWILIGHT-HBR
Authors: Escaned Javier , Cao Davide , Baber Usman , Nicolas Johny , Sartori Samantha , Zhang Zhongjie , Dangas George , Angiolillo Dominick J , Briguori Carlo , Cohen David J , Collier Timothy , Dudek Dariusz , Gibson Michael , Gil Robert , Huber Kurt , Kaul Upendra , Kornowski Ran , Krucoff Mitchell W , Kunadian Vijay , Mehta Shamir , Moliterno David J , Ohman E Magnus , Oldroyd Keith G , Sardella Gennaro , Sharma Samin K , Shlofmitz Richard , Weisz Giora , Witzenbichler Bernhard , Pocock Stuart , Mehran Roxana
Published: September 2021

Aims

Patients at high bleeding risk (HBR) represent a prevalent subgroup among those undergoing percutaneous coronary intervention (PCI). Early aspirin discontinuation after a short course of dual antiplatelet therapy (DAPT) has emerged as a bleeding avoidance strategy. The aim of this study was to assess the effects of ticagrelor monotherapy after 3-month DAPT in a contemporary HBR population.

Methods and results

This prespecified analysis of the TWILIGHT trial evaluated the treatment effects of early aspirin withdrawal followed by ticagrelor monotherapy in HBR patients undergoing PCI with drug-eluting stents. After 3 months of ticagrelor plus aspirin, event-free patients were randomized to 12 months of aspirin or placebo in addition to ticagrelor. A total of 1064 (17.2%) met the Academic Research Consortium definition for HBR. Ticagrelor monotherapy reduced the incidence of the primary endpoint of Bleeding Academic Research Consortium (BARC) 2, 3, or 5 bleeding compared with ticagrelor plus aspirin in HBR (6.3% vs. 11.4%; hazard ratio (HR) 0.53, 95% confidence interval (CI) 0.35–0.82) and non-HBR patients (3.5% vs. 5.9%; HR 0.59, 95% CI 0.46–0.77) with similar relative (P  interaction = 0.67) but a trend towards greater absolute risk reduction in the former [−5.1% vs. −2.3%; difference in absolute risk differences (ARDs) −2.8%, 95% CI −6.4% to 0.8%, P = 0.130]. A similar pattern was observed for more severe BARC 3 or 5 bleeding with a larger absolute risk reduction in HBR patients (−3.5% vs. −0.5%; difference in ARDs −3.0%, 95% CI −5.2% to −0.8%, P = 0.008). There was no significant difference in the key secondary endpoint of death, myocardial infarction, or stroke between treatment arms, irrespective of HBR status.

Conclusions

Among HBR patients undergoing PCI who completed 3-month DAPT without experiencing major adverse events, aspirin discontinuation followed by ticagrelor monotherapy significantly reduced bleeding without increasing ischaemic events, compared with ticagrelor plus aspirin. The absolute risk reduction in major bleeding was larger in HBR than non-HBR patients.
Elevated peripheral blood neutrophil-to-lymphocyte ratio is associated with an immunosuppressive tumour microenvironment and decreased benefit of PD-1 antibody in advanced gastric cancer
Authors: Ruan Dan-Yun , Chen Yan-Xing , Wei Xiao-Li , Wang Ying-Nan , Wang Zi-Xian , Wu Hao-Xiang , Xu Rui-Hua , Yuan Shu-Qiang , Wang Feng-Hua
Published: September 2021

Background

Due to its limited efficacy and potential toxicity, anti-PD-1 monoclonal antibody is not suitable for all advanced gastric cancer (AGC) patients and predictive biomarkers identifying patients who can benefit from it are urgently needed. This study aimed to evaluate the predictive and prognostic value of inflammatory markers in the context of the systemic inflammatory status and tumour microenvironment.

Methods

The study included 58 patients from a prospective study investigating the safety and efficacy of toripalimab in chemorefractory AGC patients. Patient characteristics, treatment outcomes, and haematological parameters were analysed. Immune-cell infiltration and gene expression in tumour tissue were examined using transcriptome sequencing.

Results

In this cohort, the median follow-up time was 4.5 months, the median progression-free survival was 1.9 months, and the median overall survival (OS) was 4.8 months. The objective response rate was 12.1% and th disease control rate (DCR) was 39.7%. Both the baseline blood neutrophil-to-lymphocyte ratio (bNLR) with a cut-point of 2.7 and the early elevated dynamic change of the bNLR (dNLR) with a cut-point of 1.5 were prognostic factors of survival. Patients in the high bNLR or dNLR group had remarkably poor DCR (25.8% vs 59.1%, P = 0.023; 15.8% vs 54.6%, P = 0.008). In multivariate analysis, bNLR and tumour mutational burden were independent prognostic factors of OS. Tumour RNA-seq analysis revealed enriched neutrophil infiltration and a higher tumour NLR in the bNLR-high group. Corresponding tumour gene-expression profiles were associated with neutrophil recruitment and inflammatory cytokine aggregation.

Conclusions

Our study demonstrated the potential clinical utility of NLR as a biomarker for patient selection and clinical management in predicting the prognosis of AGC patients as well as response to anti-PD-1 therapy. In addition, high bNLR reflected the imbalance of tumour-tissue-infiltrating neutrophils and lymphocytes, and was associated with an immunosuppressive and pro-tumour microenvironment.
Adiponectin, Leptin, and Resistin and the Risk of Dementia
Authors: Mooldijk Sanne S , Ikram Mohammad Kamran , Ikram Mohammad Arfan
Published: September 2021

Background

Adipokines are hormones secreted by adipose tissue with roles in energy homeostasis and regulation of metabolism. Their dysregulation is suggested to contribute to the increased risk of dementia seen with midlife obesity, but longitudinal studies investigating this are scarce. We determined the association between plasma levels of adiponectin, leptin, and resistin with the risk of dementia.

Methods

We performed a case–cohort study embedded in the prospective, population-based Rotterdam Study. Plasma levels of the adiponectin, leptin, and resistin were measured at baseline (1997–1999) in a random subcohort of 945 participants without dementia, and additionally in 177 participants, who were diagnosed with dementia during follow-up (until January 1, 2018).

Results

Higher levels of leptin and resistin were associated with a decreased risk of dementia (adjusted hazard ratio [95% confidence interval] per SD increase of log-transformed values: 0.85 [0.72–1.00] for leptin; 0.82 [0.71–0.95] for resistin). The association of leptin with dementia was further modified by body mass index and by APOE ε4 carrier status. Adiponectin levels were not associated with the risk of dementia.

Conclusions

These findings support the hypothesis that adipokines have a role in the pathophysiology of dementia. Future studies are warranted to confirm the findings and to explore the underlying mechanisms.
Visual Art Therapy and Cognition: Effects on People With Mild Cognitive Impairment and Low Education Level
Authors: Masika Golden M , Yu Doris S F , Li Polly W C , Lee Diana T F , Nyundo Azan
Published: September 2021

Objectives

The aim of this study was to examine the effects of visual art therapy (VAT) on cognition, psychological and functional ability of people with mild cognitive impairment (MCI), and low education.

Methods

A single-blinded randomized controlled trial was conducted among 127 older adults with MCI, mean age 73.6 years, and level of education in years, median (range) = 0 (0–9). The intervention group received 12 VAT sessions over 6 weeks. The control group received 6 health education sessions. The outcomes measures at baseline, immediately postintervention, at 3-month, and 6-month follow-up included global cognitive functions, depression, mental well-being, and instrumental activities of daily living functions.

Results

The intervention group demonstrated greater improvement than the control group in global cognition (β = 2.56, 95% confidence interval [CI] = 1.16, 3.97, p < .001, standardized mean difference [SMD] = 0.75) and depression (β = −2.01, 95% CI = −3.09, −0.93, p < .001, SMD = −0.93) immediately postintervention. The effects on cognitive functions were sustained at 3 and 6 months follow-up. The differential effect of VAT on mental well-being and functional ability compared to health education were undetectable.

Discussion

VAT can improve cognitive functions and mood status of older adults with MCI who have no or low education.

Clinical Trials Registration Number: PACTR201901731800445. This trial was registered with Pan African Clinical Trial Registry: www.pactr.org.
Evaluation of the Safety, Tolerability, and Pharmacokinetic Profiles of TP0473292 (TS-161), A Prodrug of a Novel Orthosteric mGlu2/3 Receptor Antagonist TP0178894, in Healthy Subjects and Its Antidepressant-Like Effects in Rodents
Authors: Watanabe Mai , Marcy Brian , Hiroki Ayano , Watase Hirotaka , Kinoshita Kohnosuke , Iijima Michihiko , Marumo Toshiyuki , Zarate Carlos A , Chaki Shigeyuki
Published: September 2021

Background

TP0473292 (the active ingredient of TS-161) is a prodrug of a novel metabotropic glutamate (mGlu) 2/3 receptor antagonist being developed for the treatment of patients with depression. This study evaluated the safety, tolerability, and pharmacokinetics of orally administered TS-161 in healthy subjects.

Methods

This was a first-in-human, phase 1, randomized, double-blind, placebo-controlled, single-ascending dose (15–400 mg TS-161) and 10-day multiple-ascending dose (50–150 mg TS-161) study in healthy subjects, conducted from June 2019 through February 2020. Plasma and urine concentrations of the prodrug and its metabolites, and cerebrospinal fluid (CSF) concentrations of the active metabolite TP0178894 were measured to evaluate the pharmacokinetic profiles after oral administration of TS-161.

Results

Following single and multiple doses, TP0473292 was extensively converted into its active metabolite TP0178894. Plasma concentrations of TP0178894 reached peak (Cmax) within 5 hours post dose and declined with a t1/2 <13 hours. Plasma exposures of TP0178894 increased with increasing dose. TP0178894 penetrated into CSF and reached a Cmax of 9.892 ng/mL at a single dose of 100 mg, which was comparable with IC50 values of antagonist activity at mGlu2/3 receptors. The most frequently observed adverse events that showed exposure-related incidence during the study were nausea, vomiting, and dizziness.

Conclusions

The mGlu2/3 receptor antagonist prodrug TP0473292 is safe and well-tolerated, is orally bioavailable in humans with extensive conversion into the active metabolite TP0178894 with sufficient CSF penetration to exert the anticipated pharmacological effects, and is a promising candidate for further clinical development in treatment of patients with depression.
Primary eye care: opportunities for health system strengthening and improved access to services
Authors: Yasmin Sumrana , Schmidt Elena
Published: September 2021

Primary eye care (PEC) is a vital component of primary healthcare (PHC) and is the cornerstone for the progress towards universal eye health coverage. While the concept of PEC is not new, with the increased focus of the global eye-health agenda on equity and people-centred care, it is critical to review experiences of delivering PEC in low- and middle-income countries and to identify common lessons learnt. This commentary builds on the available evidence and focuses specifically on three recently published evaluations of PEC in Sightsavers-supported programmes in Tanzania, Sierra Leone and Pakistan. It argues that systems thinking is critical in the delivery of PEC interventions, as only this approach can ensure that the integration of PEC into PHC is delivered in a comprehensive, coherent and sustainable way.
A commitment and call to strengthen and expand qualitative research efforts to improve the impact of antimicrobial stewardship
Authors: van den Bergh Dena , Brink Adrian
Published: September 2021

Inadequate recognition of the value of qualitative research in healthcare, notably in antimicrobial stewardship (AMS), in addition to a lack of publishing space in medical journals has prompted JAC-Antimicrobial Resistance to focus on a qualitative series of AMS papers to incite interest in and support for pivotal qualitative approaches that make an indispensable contribution to our understanding of antibiotic use and how to address antimicrobial resistance. In this series, invited authors with diverse backgrounds and considerable expertise address and review intricate and varying qualitative research methods, behaviour change determinants, interventions and qualitative perspectives, with the aim of strengthening commitment and expanding qualitative initiatives to further the impact of AMS globally.
PhenClust, a standalone tool for identifying trends within sets of biological phenotypes using semantic similarity and the Unified Medical Language System metathesaurus
Authors: Wilson Jennifer L , Wong Mike , Stepanov Nicholas , Petkovic Dragutin , Altman Russ
Published: September 2021

Objectives

We sought to cluster biological phenotypes using semantic similarity and create an easy-to-install, stable, and reproducible tool.

Materials and Methods

We generated Phenotype Clustering (PhenClust)—a novel application of semantic similarity for interpreting biological phenotype associations—using the Unified Medical Language System (UMLS) metathesaurus, demonstrated the tool’s application, and developed Docker containers with stable installations of two UMLS versions.

Results

PhenClust identified disease clusters for drug network-associated phenotypes and a meta-analysis of drug target candidates. The Dockerized containers eliminated the requirement that the user install the UMLS metathesaurus.

Discussion

Clustering phenotypes summarized all phenotypes associated with a drug network and two drug candidates. Docker containers can support dissemination and reproducibility of tools that are otherwise limited due to insufficient software support.

Conclusion

PhenClust can improve interpretation of high-throughput biological analyses where many phenotypes are associated with a query and the Dockerized PhenClust achieved our objective of decreasing installation complexity.
Pollen Treated with a Combination of Agrochemicals Commonly Applied During Almond Bloom Reduces the Emergence Rate and Longevity of Honey Bee (Hymenoptera: Apidae) Queens
Authors: Ricke Dylan F , Lin Chia-Hua , Johnson Reed M
Published: September 2021

Honey bee (Apis mellifera L.) colonies that pollinate California’s almond orchards are often exposed to mixtures of agrochemicals. Although agrochemicals applied during almond bloom are typically considered bee-safe when applied alone, their combined effects to honey bees are largely untested. In recent years, beekeepers providing pollination services to California’s almond orchards have reported reductions in queen quality during and immediately after bloom, raising concerns that pesticide exposure may be involved. Previous research identified a synergistic effect between the insecticide active ingredient chlorantraniliprole and the fungicide active ingredient propiconazole to lab-reared worker brood, but their effects to developing queens are unknown. To test the individual and combined effects of these pesticides on the survival and emergence of developing queens, we fed worker honey bees in closed queen rearing boxes with pollen artificially contaminated with formulated pesticides containing these active ingredients as well as the spray adjuvant Dyne-Amic, which contains both organosilicone and alkyphenol ethoxylate. The translocation of pesticides from pesticide-treated pollen into the royal jelly secretions of nurse bees was also measured. Despite consistently low levels of all pesticide active ingredients in royal jelly, the survival of queens from pupation to 7 d post-emergence were reduced in queens reared by worker bees fed pollen containing a combination of formulated chlorantraniliprole (Altacor), propiconazole (Tilt), and Dyne-Amic, as well as the toxic standard, diflubenzuron (Dimilin 2L), applied in isolation. These results support recommendations to protect honey bee health by avoiding application of pesticide tank-mixes containing insecticides and adjuvants during almond bloom.
Capillary hemangioma in the external auditory canal
Authors: Jeong Junhui
Published: September 2021

Hemangioma is a benign vascular soft tissue tumor. It is the most common soft tissue tumor in children and >60% of hemangiomas occur in the head and neck region. However, these tumors are rare in the external auditory canal (EAC). This case report describes a case of capillary hemangioma in the EAC in a woman 54 years of age. With the patient under local anesthesia in microscopic surgery, the mass was excised completely via a transcanal approach. If there is a cystic and pinkish mass in the EAC with symptoms of bleeding or pulsatile tinnitus, hemangioma should be considered. For symptomatic hemangioma, complete surgical excision is necessary and the prognosis is good after excision. Histopathologic confirmation is mandatory after excision.
Binaries are softer than they seem: effects of an external potential on the scattering dynamics of binaries
Authors: Ginat Yonadav Barry , Perets Hagai B
Published: September 2021

Binary evolution is influenced by dynamical scattering with other stars in dense environments. Heggie’s law states that, due to their environments, hard binaries (whose orbital energy surpasses the typical energy of single stars) tend to harden (increase their orbital energy), while soft binaries typically soften. Here, we show that Heggie’s law sometimes needs to be revised, by accounting for an external potential, for example, for binaries in nuclear stellar discs or active galactic nucleus discs, that are affected by the central massive black hole, or binary planetesimals in protoplanetary discs, affected by the host star. We find that in such environments, where the Hill radius is finite, binary-single scattering can have different outcomes. In particular, a three-body encounter could be cut short due to stars being ejected beyond the Hill radius, thereby ceasing to participate in further close interactions. This leads to a systematic difference in the energy changes brought about by the encounter, and in particular slows binary hardening, and even causes some hard binaries to soften, on average, rather than harden. We use our previously derived analytical, statistical solution to the bound chaotic three-body problem to quantitatively characterise the revision of the hardening-softening phase transition and evolution of binaries. We also provide an analytical calculation of the mean hardening rate of binaries in any environment (also reproducing the results of detailed N-body simulations). We show that the latter exhibits a non-trivial dependence on the Hill radius induced by the environment.
Spectral separation of the stochastic gravitational-wave background for LISA in the context of a modulated Galactic foreground
Authors: Boileau Guillaume , Lamberts Astrid , Christensen Nelson , Cornish Neil J , Meyer Renate
Published: September 2021

Within its observational band the Laser Interferometer Space Antenna, LISA, will simultaneously observe orbital modulated waveforms from Galactic white dwarf binaries, a binary black hole produced gravitational-wave background, and potentially a cosmologically created stochastic gravitational-wave background (SGWB). The overwhelming majority of stars end their lives as white dwarfs, making them very numerous in the Milky Way. We simulate Galactic white dwarf binary gravitational-wave emission based on distributions from various mock catalogues and determine a complex waveform from the Galactic foreground with 3.5 × 107 binaries. We describe the effects from the Galactic binary distribution population across mass, position within the Galaxy, core type, and orbital frequency distribution. We generate the modulated Galactic white dwarf signal detected by LISA due to its orbital motion, and present a data analysis strategy to address it. The Fisher Information and Markov Chain Monte Carlo methods give an estimation of the LISA noise and the parameters for the different signal classes. We estimate the detectable limits for the future LISA observation of the SGWB in the spectral domain with the three LISA channels A, E, and T. We simultaneously estimate the Galactic foreground, the astrophysical and cosmological backgrounds. Assuming the expected astrophysical background and a Galactic foreground, a cosmological background energy density of around ΩGW,cosmo ≈ 8 × 10−13 could be detected by LISA. LISA will either detect a cosmologically produced SGWB, or set a limit that will have important consequences.
LeMMINGs III. Thee-MERLIN legacy survey of the Palomar sample: exploring the origin of nuclear radio emission in active and inactive galaxies through the [O iii] – radio connection
Authors: Baldi R D , Williams D R A , Beswick R J , McHardy I , Dullo B T , Knapen J H , Zanisi L , Argo M K , Aalto S , Alberdi A , Baan W A , Bendo G J , Fenech D M , Green D A , Klöckner H-R , Körding E , Maccarone T J , Marcaide J M , Mutie I , Panessa F , Pérez-Torres M A , Romero-Cañizales C , Saikia D J , Saikia P , Shankar F , Spencer R E , Stevens I R , Uttley P , Brinks E , Corbel S , Martí-Vidal I , Mundell C G , Pahari M , Ward M J
Published: September 2021

What determines the nuclear radio emission in local galaxies? To address this question, we combine optical [O iii] line emission, robust black hole (BH) mass estimates, and high-resolution e-MERLIN 1.5-GHz data, from the LeMMINGs survey, of a statistically complete sample of 280 nearby optically active (LINER and Seyfert) and inactive [H ii and absorption line galaxies (ALGs)] galaxies. Using [O iii] luminosity ($L_{\rm [O\, \small {III}]}$) as a proxy for the accretion power, local galaxies follow distinct sequences in the optical–radio planes of BH activity, which suggest different origins of the nuclear radio emission for the optical classes. The 1.5-GHz radio luminosity of their parsec-scale cores (Lcore) is found to scale with BH mass (MBH) and [O iii] luminosity. Below MBH ∼ 106.5 M⊙, stellar processes from non-jetted H ii galaxies dominate with $L_{\rm core} \propto M_{\rm BH}^{0.61\pm 0.33}$ and $L_{\rm core} \propto L_{\rm [O\, \small {III}]}^{0.79\pm 0.30}$. Above MBH ∼ 106.5 M⊙, accretion-driven processes dominate with $L_{\rm core} \propto M_{\rm BH}^{1.5-1.65}$ and $L_{\rm core} \propto L_{\rm [O\, \small {III}]}^{0.99-1.31}$ for active galaxies: radio-quiet/loud LINERs, Seyferts, and jetted H ii galaxies always display (although low) signatures of radio-emitting BH activity, with $L_{\rm 1.5\, GHz}\gtrsim 10^{19.8}$ W Hz−1 and MBH ≳ 107 M⊙, on a broad range of Eddington-scaled accretion rates ($\dot{m}$). Radio-quiet and radio-loud LINERs are powered by low-$\dot{m}$ discs launching sub-relativistic and relativistic jets, respectively. Low-power slow jets and disc/corona winds from moderately high to high-$\dot{m}$ discs account for the compact and edge-brightened jets of Seyferts, respectively. Jetted H ii galaxies may host weakly active BHs. Fuel-starved BHs and recurrent activity account for ALG properties. In conclusion, specific accretion–ejection states of active BHs determine the radio production and the optical classification of local active galaxies.
Faster Rates of Molecular Sequence Evolution in Reproduction-Related Genes and in Species with Hypodermic Sperm Morphologies
Authors: Wiberg R Axel W , Brand Jeremias N , Schärer Lukas
Published: September 2021

Sexual selection drives the evolution of many striking behaviors and morphologies and should leave signatures of selection at loci underlying these phenotypes. However, although loci thought to be under sexual selection often evolve rapidly, few studies have contrasted rates of molecular sequence evolution at such loci across lineages with different sexual selection contexts. Furthermore, work has focused on separate sexed animals, neglecting alternative sexual systems. We investigate rates of molecular sequence evolution in hermaphroditic flatworms of the genus Macrostomum. Specifically, we compare species that exhibit contrasting sperm morphologies, strongly associated with multiple convergent shifts in the mating strategy, reflecting different sexual selection contexts. Species donating and receiving sperm in every mating have sperm with bristles, likely to prevent sperm removal. Meanwhile, species that hypodermically inject sperm lack bristles, potentially as an adaptation to the environment experienced by hypodermic sperm. Combining functional annotations from the model, Macrostomum lignano, with transcriptomes from 93 congeners, we find genus-wide faster sequence evolution in reproduction-related versus ubiquitously expressed genes, consistent with stronger sexual selection on the former. Additionally, species with hypodermic sperm morphologies had elevated molecular sequence evolution, regardless of a gene’s functional annotation. These genome-wide patterns suggest reduced selection efficiency following shifts to hypodermic mating, possibly due to higher selfing rates in these species. Moreover, we find little evidence for convergent amino acid changes across species. Our work not only shows that reproduction-related genes evolve rapidly also in hermaphroditic animals, but also that well-replicated contrasts of different sexual selection contexts can reveal underappreciated genome-wide effects.
Effectiveness of nutrition interventions on improving diet quality and nutrition knowledge in military populations: a systematic review
Authors: Kullen Charina , Mitchell Lachlan , O’Connor Helen T , Gifford Janelle A , Beck Kathryn L
Published: September 2021

Context

Optimizing nutrition in military groups through improved diet quality and nutrition knowledge is key in supporting the high physical and cognitive demands.

Objective

The objective of this investigation was to systematically review the effectiveness of nutrition interventions among military personnel in improving diet quality and/or nutrition knowledge.

Data Sources

Medline, Embase, CINAHL, and Scopus were searched from the earliest records to May 2020.

Data Extraction

Data were extracted by 2 reviewers. The primary outcomes were diet quality and/or nutrition knowledge.

Data Analysis

Twenty studies were included. The main intervention approaches identified were nutrition education of individuals (i.e., education-based studies; EB) (n = 12), and manipulation of the food service environment (i.e., dining facility studies; DFACs) (n = 8). The most common strategies were face-to-face lectures (n = 8) for EB, and healthier menus (n = 7) and education of catering staff (n = 6) for DFAC interventions. Most studies (18/20) demonstrated favorable within-group effects; however, dietary changes were inconsistent. Five of 10 studies using a comparator group demonstrated positive between-group differences.

Conclusion

Although potential exists for improving diet quality and nutrition knowledge in military populations, the heterogeneity of the studies to date limits conclusions on the most efficacious strategies.
A systematic review of supermarket automated electronic sales data for population dietary surveillance
Authors: Jenneson Victoria L , Pontin Francesca , Greenwood Darren C , Clarke Graham P , Morris Michelle A
Published: September 2021

Context

Most dietary assessment methods are limited by self-report biases, how long they take for participants to complete, and cost of time for dietitians to extract content. Electronically recorded, supermarket-obtained transactions are an objective measure of food purchases, with reduced bias and improved timeliness and scale.

Objective

The use, breadth, context, and utility of electronic purchase records for dietary research is assessed and discussed in this systematic review.

Data sources

Four electronic databases (MEDLINE, EMBASE, PsycINFO, Global Health) were searched. Included studies used electronically recorded supermarket transactions to investigate the diet of healthy, free-living adults.

Data extraction

Searches identified 3422 articles, of which 145 full texts were retrieved and 72 met inclusion criteria. Study quality was assessed using the National Institutes of Health Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies.

Data analysis

Purchase records were used in observational studies, policy evaluations, and experimental designs. Nutrition outcomes included dietary patterns, nutrients, and food category sales. Transactions were linked to nutrient data from retailers, commercial data sources, and national food composition databases.

Conclusion

Electronic sales data have the potential to transform dietary assessment and worldwide understanding of dietary behavior. Validation studies are warranted to understand limits to agreement and extrapolation to individual-level diets.

Systematic Review Registration

PROSPERO registration no. CRD42018103470
Rethinking Administrative Law for Algorithmic Decision Making
Authors: Williams Rebecca
Published: September 2021

The increasing prevalence of algorithmic decision making (ADM) by public authorities raises a number of challenges for administrative law in the form of technical decisions about the necessary metrics for evaluating such systems, their opacity, the scalability of errors, their use of correlation as opposed to causation and so on. If administrative law is to provide the necessary guidance to enable optimal use of such systems, there are a number of ways in which it will need to become more nuanced and advanced. However, if it is able to rise to this challenge, administrative law has the potential not only to do useful work itself in controlling ADM, but also to support the work of the Information Commissioner’s Office and provide guidance on the interpretation of concepts such as ‘meaningful information’ and ‘proportionality’ within the General Data Protection Regulation.
Solar geoengineering governance: a dynamic framework of farsighted coalition formation
Authors: Heyen Daniel , Lehtomaa Jere
Published: September 2021

Climate interventions with solar geoengineering could reduce climate damages if deployed in a globally coordinated regime. In the absence of such a regime, however, strategic incentives of single actors might result in detrimental outcomes. A well-known concern is that a ‘free-driver’ (Weitzman ML. A voting architecture for the governance of free-driver externalities, with application to geoengineering. Scand J Econ 2015;117:1049–68), the country with the strongest preference for cooling, might unilaterally set the global thermostat to its preferred level, thus imposing damages on others. Governance structures, i.e. more or less formal institutional arrangements between countries, could steer the decentralized geoengineering deployment towards the preferable global outcome. In this paper, we show that the coalition formation literature can make a valuable contribution to assessing the relative merit of different governance schemes. An important feature of the coalition formation literature is the sophisticated dynamic structure. A country pondering whether to leave a coalition anticipates that its departure could spark another process of disintegration among the remaining members of that coalition, which in turn may affect the assessment of whether leaving the coalition is worthwhile in the first place. This dynamic structure thus enables a more realistic picture of what coalitions are likely to form and remain stable. A second important feature of coalition formation models is wide control over the ‘rules of the game’, for instance, which agents need to consent to a transition from one coalitional arrangement to another. This control over the institutional setting allows consistently comparing and discussing various international governance arrangements.
Political and Social Consequences of Qualification Mismatches: A Bounding Approach to Status Inconsistency
Authors: Wiedner Jonas
Published: September 2021

Many employees work in jobs that do not match their level of formal education. Status inconsistency theory (SIT) argues that such mismatches result in stress, dissatisfaction, political alienation, and social withdrawal. Status inconsistency may, therefore, pose a threat to social cohesion. However, extant SIT scholarship does not fully appreciate the consequences of an identification problem due to the perfect collinearity among the effects of occupation, education, and their mismatch. I review the literature and show that prior findings depend on implicit theoretical assumptions that are often implausible once spelled out. To overcome this problem, I propose a new approach to the study of mismatches that builds on recent advances in the modeling of age, period, and cohort effects. I demonstrate how a set of relatively weak assumptions that are transparently grounded in sociological theory allows for (partial) identification of mismatch effects. The empirical analysis draws on comparable large-scale survey data from the United Kingdom (UKLHS) and Germany (GSOEP), two countries with a very different institutional organization of education to job matching. Compared with previous research, I use theoretically justified identifying assumptions and provide more rigorous evidence by addressing non-random selection into mismatch. Constrained regression models show mismatch effects on work-related identities, satisfaction, and organizational integration. Contra SIT, my results suggest that the effects of mismatches do not arise from cognitive dissonance but from an expectation formation mechanism. I find only weak evidence that mismatch effects spill over into the political domain. Despite large institutional differences, the results are similar across countries.
Phenology explains different storage remobilization in two congeneric temperate tree species with contrasting leaf habit
Authors: Löiez Sidonie , Piper Frida I
Published: September 2021

The dependence of trees on carbon and nutrient storage is critical to predicting the forest vulnerability under climate change, but whether evergreen and deciduous species differ in their use and allocation of stored resources during spring phenology is unclear. Using a high temporal resolution, we evaluated the role of spring phenology and shoot growth as determinants of the carbon and nutrient storage dynamics in contrasting leaf habits. We recorded the phenology and shoot elongation and determined the concentrations of total non-structural carbohydrates (NSCs), starch, soluble carbohydrates, nitrogen (N) and phosphorus (P) in buds, expanding shoots and previously formed shoots of two sympatric Nothofagus species with contrasting leaf habit. Species reached similar shoot lengths, though shoot expansion started 35 days earlier and lasted c. 40 days more in the deciduous species. Thus, although the deciduous species had a relatively constant shoot growth rate, the evergreen species experienced a conspicuous growth peak for c. 20 days. In the evergreen species, the greatest decreases in NSC concentrations of previously formed shoots and leaves coincided with the maximum shoot expansion rate and fruit filling, with minimums of 63 and 65% relative to values at bud dormancy, respectively. In contrast, minimum NSC concentrations of the previously formed shoots of the deciduous species were only 73% and occurred prior to the initiation of shoot expansion. Bud N and P concentrations increased during budbreak, whereas previously formed shoots generally did not decrease their nutrient concentrations. Late spring phenology and overlapping of phenophases contributed to the greater dependence on storage of proximal tissues in the studied evergreen compared with deciduous species, suggesting that phenology is a key determinant of the contrasting patterns of storage use in evergreen and deciduous species.
Comparing the Fungicide Sensitivity of Sclerotinia sclerotiorum Using Mycelial Growth and Ascospore Germination Assays
Authors: da Silva Lehner Miller , Alves Kaique S. , Del Ponte Emerson M. , Pethybridge Sarah J.
Published: September 2021

The infection of the floral tissues of snap bean and other crops by Sclerotinia sclerotiorum, the causative agent of white mold, is by ascospores. Irrespective of the fungicide mode of action being evaluated, in vitro fungicide sensitivity tests are conducted almost exclusively using mycelial growth assays. This is likely because of difficulties and time involved in sclerotial conditioning required to produce apothecia and ascospores. The objective of this research was to compare estimates of fungicide sensitivity between mycelial growth and ascospore germination assays for S. sclerotiorum. Sensitivity assays were conducted using serial doses of three fungicides commonly used to control white mold: boscalid, fluazinam, and thiophanate-methyl. A total of 27 isolates were evaluated in replicated trials conducted for each fungicide and assay type. The effective concentration to reduce mycelial growth or ascospore germination by 50% (EC50) was estimated for each isolate, fungicide, and assay type. The median EC50 values obtained from ascospore germination assays were 52.7, 10.0, and 2.7 times higher than those estimated from the mycelial growth for boscalid, fluazinam, and thiophanate-methyl, respectively. No significant correlation was found between EC50 values estimated by the two methods. These findings highlight differences that may be important in evaluating the sensitivity of S. sclerotiorum given the fungicide mode of action and how they will be used in the field.
Medical Ethics, Moral Courage, and the Embrace of Fallibility
Authors: Kreitmair Karola V.
Published: September 2021

Experts have an obligation to make difficult decisions rather than offloading these decisions onto others who may be less well equipped to make them. This commentary considers this obligation through the lens of drafting critical care rationing protocols to address COVID-19–induced scarcity. The author recalls her own experience as a member of multiple groups charged with the generation of protocols for how hospitals and states should ration critical care resources like ventilators and intensive care unit beds, in the event that there would not be enough to go around as the COVID-19 pandemic intensified. She identifies several obvious lessons learned through this process, including the need to combat the pervasive effects of racism, ableism, and other forms of discrimination; to enhance the diversity, equity, and inclusion built into the process of drafting rationing protocols; and to embrace transparency, including acknowledging failings and fallibility. She also comes to a more complicated conclusion: Individuals in a position of authority, such as medical ethicists, have a moral obligation to embrace assertion, even when such assertions may well turn out to be wrong. She notes that when the decision-making process is grounded in legitimacy, medical ethics must have the moral courage to embrace fallibility.
Safety and Immunogenicity of a 20-valent Pneumococcal Conjugate Vaccine in Healthy Infants in the United States
Authors: Senders Shelly , Klein Nicola P. , Lamberth Erik , Thompson Allison , Drozd Jelena , Trammel James , Peng Yahong , Giardina Peter C. , Jansen Kathrin U. , Gruber William C. , Scott Daniel A. , Watson Wendy
Published: September 2021

Background:

The development and widespread use of pneumococcal conjugate vaccines (PCVs) substantially reduced the global burden of pneumococcal disease. Expanding the serotypes covered by PCVs may further reduce disease burden. A 20-valent PCV (PCV20) has been developed to add coverage for 7 additional serotypes (8, 10A, 11A, 12F, 15B, 22F and 33F) to those in the existing 13-valent PCV (PCV13). This phase 2 study evaluated the safety, tolerability and immunogenicity of PCV20 in healthy US infants.

Methods:

In this randomized, active-controlled, double-blind study, 460 infants were randomized 1:1 to receive a 4-dose series of either PCV20 or PCV13 at 2, 4, 6 and 12 months of age. Solicited local reactions and systemic events, adverse events (AEs) and serious AEs were recorded. Immunogenicity was assessed by measuring serotype-specific IgG concentrations and opsonophagocytic activity titers at 1 month after Dose 3, before Dose 4 and 1 month after Dose 4.

Results:

Of 460 infants, 82.8% completed the 1-month visit after Dose 4. Local reactions and systemic events were mostly mild to moderate in severity and similar between the PCV20 and PCV13 groups. Treatment-related AEs were uncommon, with no related serious AEs or deaths reported. IgG and opsonophagocytic activity responses elicited by PCV20 were robust and demonstrated a booster response after Dose 4.

Conclusions:

Administration of PCV20 in US infants was well tolerated, with a safety profile similar to PCV13, and induced robust serotype-specific immune responses. These findings support continued development of PCV20 in the pediatric population.
Modified Yamane technique with a 26-gauge needle: single corneal incision and simplified haptic insertion
Authors: Tang Yong , Gao Yanlin , Chu Yanhua , Liu Yuyan , Han Quanhong
Published: September 2021

A modified Yamane technique with a 26-gauge needle for aphakia correction is described. Single corneal or corneoscleral incision is set at 12 o'clock. The 26-gauge needles are used to make 2 angled incisions parallel to the limbus to fix the haptics of a 3-piece intraocular lens. The modifications provide an easier and safer way of haptic insertion into the needle tip and decreases the possibility of bending or breaking the haptic.
Effect of time since primary laser-assisted in situ keratomileusis on flap relift success and epithelial ingrowth risk
Authors: Chang John S.M. , Liu Sylvia C.T. , Ma Nadine T.C. , Katsev Blake , Ng Jack C.M.
Published: September 2021

Purpose:

To assess the association of time since primary laser-assisted in situ keratomileusis (LASIK) with flap relift success and risk for epithelial ingrowth (EI) in eyes undergoing flap relift after primary LASIK.

Setting:

Hong Kong Sanatorium & Hospital, Hong Kong Special Administrative Region.

Design:

Retrospective observational case series.

Methods:

73 eyes with flaps relifted for refractive enhancement LASIK were included. Main outcome measures included rate of relift success and EI; associations of time since primary LASIK, sex, age at relift, year of relift, and flap creation method in primary LASIK with relift success and EI.

Results:

Of the 73 eyes included, relifting was successful in 71 eyes (97.3%). Among the successfully relifted eyes, 12 (16.9%) developed EI, of which 3 (4.2%) were clinically significant. No eyes lost more than 1 line of corrected distance visual acuity. The time since primary LASIK (up to 22 years), sex, age at relift, year of relift, and flap creation method in primary LASIK were not associated with relift success or EI.

Conclusions:

With the described surgical technique, flaps could be successfully relifted without much difficulty up to 22 years after primary LASIK with a low incidence of EI.
Socioeconomic, Psychosocial, and Clinical Factors Associated With Employment in Women With HIV in the United States: A Correlational Study
Authors: Wise Jenni M. , Azuero Andres , Konkle-Parker Deborah , Raper James L. , Heaton Karen , Vance David E. , Adimora Adaora A. , Wingood Gina , Golub Elizabeth , Levin Susanna , Wilson Tracey E. , Merenstein Daniel , Yelin Ed , Weber Kathleen M. , Fischl Margaret , Kempf Mirjam-Colette
Published: September 2021

Employment is a social determinant of health, and women living with HIV (WLWH) are often underemployed. This correlational study examined the socioeconomic, psychosocial, and clinical factors associated with employment among WLWH (n = 1,357) and women at risk for HIV (n = 560). Descriptive and inferential statistics were used to evaluate factors associated with employment status. Employment was associated (p ≤ .05) with better socioeconomic status and quality of life (QOL), less tobacco and substance use, and better physical, psychological, and cognitive health. Among WLWH, employment was associated (p ≤ .05) with improved adherence to HIV care visits and HIV RNA viral suppression. Using multivariable regression modeling, differences were found between WLWH and women at risk for HIV. Among WLWH, household income, QOL, education, and time providing childcare remained associated with employment in adjusted multivariable analyses (R
2 = .272, p < .001). A better understanding of the psychosocial and structural factors affecting employment is needed to reduce occupational disparities among WLWH.