bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring the Phenotypic Spectrum of KCNB1: A Case Series of Two Unique Presentations
Authors:   Kasturba Medical College, Manipal, India, S Joshi , P Patil ,   Pediatric Neurology, Emory University School of Medicine, USA, L Davis ,   Pediatric Neurology, Emory University School of Medicine, USA, M Black ,   Pediatric Neurology, Emory University School of Medicine, USA
Published: November 2024

Background and Purpose: We present two cases exemplifying the broad phenotypic spectrum associated with pathogenic changes in KCNB1 protein. Our case series highlights the variability of the outcomes of this genetic condition. Methods: This is a descriptive retrospective review of medical histories of two patients under the age of 18 years with KCNB1 related neurodevelopmental disorder. We performed a literature review from published articles in PubMed indexed journals. Brief Report: A 9-year-old girl with developmental delay and autism found to have a pathogenic mutation in the KCNB1 gene presented with regression in her language, staring spells, and EEG findings suggestive of Electrographic Status Epilepticus in Sleep (ESES). She is maintained on Clobazam and continues to make gains in her milestones. A 16-year-old boy with a heterozygous mutation in the KCNB1 gene presented with mild intellectual disability and attention deficit hyperactivity disorder. His EEG showed frequent bursts of generalized, sharply contoured theta activity - a finding of uncertain clinical significance. However, no clinical seizures were mentioned. He is maintained on valproic acid for mood stabilization. Conclusion: The phenotype associated with KCNB1-related neurodevelopmental disorders is variable and includes epilepsy, intellectual disabilities, and psychiatric diagnoses. While our first patient had typical manifestations of the condition, treatment with anti-seizure medication was seen as beneficial. Our second patient had no clinical seizures, and his case highlights the importance of assessing the risk-benefit ratio of anti-seizure medication. It is important to understand the spectrum of the disease in order to identify clinical manifestations and perform early testing for a better prognosis.
Morphological Aspect and Management of Pediatric Cataract in Treacher Collins Syndrome
Authors:   Department of Ophthalmology, Centro Integrado de Oftalmologia Tartarella, São Paulo SP, Brazil, MB Tartarella , IM Verçosa ,   Department of Ophthalmology, CAVIVER Institute, Fortaleza CE, Brazil, M Caliope ,   Department of Ophthalmology, CAVIVER Institute, Fortaleza CE, Brazil, C Botelho ,   Department of Ophthalmology, CAVIVER Institute, Fortaleza CE, Brazil, M Ellery ,   Department of Ophthalmology, CAVIVER Institute, Fortaleza CE, Brazil, JB Fortes Filho ,   Department of Ophthalmology, Federal University of Rio Grande do Sul, Porto Alegre RS, Brazil
Published: November 2024

The morphological aspect of lens opacification in a 13-year-old patient with Treacher Collins Syndrome was discussed. The outcome of the cataract surgical treatment was presented. Initial visual acuity was 20/200 at the right eye and 20/100 at the left eye. A lamellar opacification of the lens, as bananatree- leaves-shaped cataracts, were observed in both eyes. Phacoemulsification with intraocular lens implantation was performed. Final visual acuity was 20/30 in both eyes. Cataract is a rare feature in Treacher Collins Syndrome and the lens opacity morphology detected in this patient was very unique.
Pressure-Controlled Nanopipette Sensing in the Asymmetric-Conductivity Configuration
Authors: Skaanvik Sebastian A. , Zhang Xinyu , McPherson Ian J. , Wang Yuqing , Larsen Anne-Kathrine K. , Sønderskov Steffan M. , Unwin Patrick R. , Zambelli Tomaso , Dong Mingdong
Published: November 2024

Nanopipettes are important tools across diverse disciplines including biology, physics, materials science, and electrochemistry, and precisely adjusting their characteristics is vital for many applications. Recent progress in this endeavor has involved using the asymmetric-conductivity configuration with different electrolyte solutions inside and outside of the nanopipette, which can greatly improve nanopipette sensing. However, understanding such measurements is challenging due to the complex interplay between diffusion, electromigration, and electroosmosis. Herein, we studied the simplified case of the asymmetric-conductivity configuration where classical ion current rectification due to ion-selective migration is minimized, while the effect of electroosmotic flow is maximized. We characterized the current-potential and current-distance relationship and revealed that this experimental configuration exhibits many of the characteristics of traditionally rectifying nanopipettes, such as surface charge sensitivity, while the current response can be understood simply from the rate and direction of solution mixing due to electroosmotic flow. To further improve the use of the asymmetric-conductivity configuration, a method was developed using external pressure to control the fluid flow rates at the aperture to tune the local ionic environment in situ, paving the way for novel, more reliable, and higher throughput nanopipette measurements.
Active Learning High Coverage Sets of Complementary Reaction Conditions
Authors: Sivilotti Sofia , Friday David , Jackson Nicholas
Published: November 2024

Chemical reaction conditions capable of producing high yields over diverse reactants will be a key component of future self driving labs. While much work has been done to discover general reaction conditions, any single conditions are necessarily limited over increasingly diverse chemical spaces. A potential solution to this problem is to identify small sets of complementary reaction conditions that, when combined, cover a much larger chemical space than any one general reaction condition. In this work, we analyze experimentally derived datasets to assess the relative performance of individual general reaction conditions vs sets of complementary reaction conditions. We then propose and benchmark active learning methods to efficiently discover these complimentary sets of conditions. The results show the value of active learning in exploring sets of reaction conditions and provide an avenue for improving synthetic hit rates in high-throughput synthesis campaigns.
Membrane Technology for Pathogenic Virus Removal: A Comprehensive Review of Centralized and Decentralized Water Treatment Processes
Authors: Wang Rui
Published: November 2024

The recent COVID-19 pandemic has once again drawn attention to the risks of pathogenic viruses, as viruses can be transmitted through water environments, posing a threat to human health. Membrane technology, as a novel, green, and effective water treatment process, has been widely applied in the removal of pathogenic viruses from wastewater and drinking water. However, compared to refined centralized water treatment processes in urban areas, rural areas still lack effective water treatment strategies for decentralized water supply and drainage systems. Therefore, this review provides a comprehensive analysis of the hazards and transmission pathways of viruses, the mechanisms and influencing factors of virus removal by membrane processes. Based on the characteristics of centralized and decentralized water treatment systems, it further summarizes the application scenarios and effectiveness of the most widely used membrane processes. We emphasize the need for context-specific development of membrane-based water treatment processes tailored to urban or rural areas, addressing both water supply and wastewater treatment processes, to ensure comprehensive public health safety in water environments. In addition, this review also discusses several challenges that membrane technology faces in virus removal, providing new insights for further research in membrane processes.
Leveraging a separation of states method for relative binding free energy calculations in systems with trapped waters
Authors: Wagle Swapnil , Merz Pascal , Ge Yunhui , Bayly Christopher , Mobley David
Published: November 2024

Methods for calculating the relative binding free energy (RBFE) between ligands to a target protein are gaining importance in the structure-based drug discovery domain, especially as methodological advances and automation improve accuracy and ease of use. In an RBFE calculation, the difference between the binding affinities of two ligands to a protein is calculated by transforming one ligand into another, in the protein-ligand complex, and in solvent. Alchemical binding free energy calculations are often used for such ligand transformations. Such calculations are not without challenges, however; for example, it can be challenging to handle interfacial waters when these play a crucial role in mediating protein-ligand binding. In some cases, the exchange of the interfacial waters with solvent water might be very infrequent in the course of typical molecular simulations, and such interfacial waters can be considered trapped on the simulation timescale. In these cases, RBFE calculation between two ligands, where one ligand binds with a trapped water while the other ligand displaces it, can result in inaccuracies if the surrounding water structure is not sampled adequately for both ligands. So far, a popular choice for treating the trapped waters in RBFE calculations is to combine free energy calculations with enhanced sampling methods that insert/delete waters in the binding site. Despite recent developments in the enhanced sampling methods, they can result in hysteresis in the RBFE estimate, depending on whether the simulations were started with or without the trapped waters. In this study, we introduce an alternative method, separation of states, to calculate the RBFE between ligand pairs where the ligands bind to the protein with different numbers/positions of trapped waters. The separation of states approach treats the sampling of the trapped waters separately from the free energy calculation of the ligand transformation. In our method, a trapped water in protein's binding site is decoupled from the system first, and the cavity created by its decoupling is stabilized. We then grow a larger ligand into this cavity-- a ligand that is known to displace the trapped water. In this study, we show that our method results in precise and accurate estimates of RBFEs for ligand pairs involving the rearrangement of trapped water via RBFE calculations for five such ligand pairs. We have optimized our simulation protocol to be suited for large distributed computational resources and have automated our RBFE calculation workflow.
Graph neural network for 3-dimensional structures including dihedral angles for molecular property prediction
Authors: Reddy Sangala Sri Abhirath , Raghunathan Shampa
Published: November 2024

The prediction of molecular properties using graph neural network (GNN) based approaches has attracted great attention in recent years. Topological molecular graphs are commonly used for representing molecules in machine learning (ML). However, the challenge is to utilize the complete geometry information, like, bonds, angles and dihedral angles while processing a molecular graph. In this work we present predictive GNN accounting three-dimensional molecular structures including the dihedral angles (GNN3Dihed) in a systematic manner. Additionally, we demonstrate that the usage of autoencoders to generate latent space embeddings for usually sparse atomic and bond vectors reduces the number of parameters in the message passing stage while not reducing performance. We compare the performance of GNN3Dihed with state-of-the-art baselines on several tasks (regression and classification), e.g., solubility prediction, toxicity prediction, binding affinity, and quantum mechanical property prediction, and showed that the present architecture often outperforms other models–demonstrating the importance of 3D structural information for ML in chemistry.
Ni–Mo Composites Deliver Performance Parity with Pt–Ru in Anion Exchange Membrane Water Electrolyzer Cathodes
Authors: Shirwalkar Advay , Kaur Manjodh , Zhong Sichen , Pupucevski Max , Hu Keda , Yan Yushan , Lattimer Judith , McKone James
Published: November 2024

The stringent cost and performance requirements of renewable hydrogen production systems dictate that next-generation electrolyzers benefit from the use of nonprecious catalysts only if they deliver the same level of activity and durability as their precious metal counterparts. Here we report on recent work to understand interrelationships between the intrinsic activity of Ni- and Pt-based electrolyzer cathode catalysts and their performance in zero-gap alkaline water electrolyzer assemblies. Our results suggest that nanoparticulate Ni--Mo exhibits approximately 5-fold lower HER activity than Pt--Ru on the basis of turnover frequency under low polarization conditions. We further found that the HER activity of Ni--Mo/C cathodes is dramatically inhibited by aryl piperidinium anion-exchange ionomers bearing bicarbonate counter-anions. After addressing this poisoning effect, we produced electrolyzer assemblies based on Ni--Mo/C cathodes that delivered statistically indistinguishable current density vs. cell potential relationships compared to otherwise identical assemblies with Pt--Ru cathodes, which we interpret as performance parity.
Efficient Piancatelli rearrangements of HMF derivatives under microwave activation or subcritical water conditions to produce functionalized hydroxylated cyclopentenones
Authors: YOUSSEF-SALIBA Sparta , MAYET Clémentine , VAN ELSLANDE Elsa , LE GOFF Géraldine , BETZER Jean-Francois
Published: November 2024

HMF (5-hydroxymethylfurfural), a renewable raw material from biomass, was used as starting material to provide 5-aryl-4-hydroxymethyl-4-hydroxycyclopentenones with functionalized aryl groups. In a first time, arylic substituents were added to the aldehyde moiety of HMF under rhodium- or palladium-catalyzed 1,2-addition of arylboronic acids, in mild conditions to respect the very sensitive HMF reactivity. In a second time, these non-symmetrical furan-2,5-dicarbinols, through Piancantelli rearrangement, provided the desired cyclopentenones under microwave activation or subcritical water conditions (100 °C and 100 bars) using the Zippertex technology, in regio- and diastereoselective manner. These synthetized bis-hydroxylated cyclopentenone derivatives exhibited significant antimicrobial activities against gram-positive bacteria Micrococcus luteus, Bacillus subtilis and gram-negative bacteria Echerichia coli.
Novel Imidazopyridine Derivatives Targeting Cytochrome bd Oxidase: A Promising Strategy to Combat Tuberculosis
Authors: Shaik Afzal , Ekambarapu Sreecharan , Kalia Nitin , Danaboina Srikanth , Nanduri Srinivas
Published: November 2024

Tuberculosis (TB) treatment is time-consuming and is further worsened due to multi-drug resistance and toxicities. Hence, there is a need for the discovery of newer antituberculosis drugs. One of the important and emerging areas of discovering new drugs is by hindering the energy metabolism generator pathway like oxidative phosphorylation (OP) which helps the sustainability of both the replicating and dormant forms of the bacterium in the host. The drugs including Telacebec (Q203) and Bedaquiline target the OP pathway enzymes cytochrome bc1 complex and ATP synthase. However, the tuberculosis bacterium survives even after the inhibition of these enzymes due to the compensatory energy production by Mycobacterium tuberculosis-cytochrome bd oxidase enzyme leading to drug resistance. Additionally, this enzyme helps the survival of the organism in aerobic conditions and in the presence of stress factors including hypoxia conditions, reactive oxygen and nitrogen species. Hence, cytochrome bd oxidase is a promising target for the discovery of novel antitubercular lead candidates. Our work employed computational techniques to design and identify novel imidazopyridines that inhibit cytochrome bd oxidase for developing antitubercular drugs. SwissSimilarity screened structurally similar compounds from the ZINC database and resulted in 989 compounds containing different rings. However, we excluded all the non-bicyclic analogues and this resulted in a library of 824 drug-like candidates as most of the bicyclic compounds showed promising inhibitory action. Further, we considered the versatile nature of amine functionality in terms of synthetic feasibility and improving the antitubercular potency and selected 262 amine-modified derivatives of imidazopyridine (1 to 262). These 262 compounds along with three reported cytochrome bd oxidase inhibitors including amiloride derivative (1a), 2-(Quinolin-4-yloxy)acetamide (2a), and 2-Arylquinolone (3a) were docked against cytochrome bd oxidase (PDB ID: 7NKZ, 2.5 Å). This process identified 255 as the best lead candidate with a docking score of -8.38 than the other 268 compounds and the reported three compounds-1a (-7.47), 2a (-5.70) and 3a (-5.35). These results suggest that the imidazopyridine derivative 255 is a promising lead compound based on its docking score and favorable binding properties indicating strong potential for further development as an anti-TB agent.
Análise de Fundos Imobiliários com Redes Neurais e Neural Tools
Authors: Rufino Mardoqueu Josue , Florencio Rosemere da Silva , Barbosa Victor de Souza , Sanches Alexandre Leme
Published: November 2024

R E S U M O
Este estudo utiliza redes neurais artificiais (RNAs) para prever o desempenho de Fundos de Investimentos Imobiliários (FIIs). Seis FIIs foram analisados com base em dados do Funds Explorer, usando os indicadores de liquidez diária, P/VP e DY (12M) acumulado. Os resultados indicam que as RNAs podem prever o desempenho dos FIIs com precisão, oferecendo uma abordagem inovadora para investidores e gestores.
Palavras-chave: Fundos de Investimento Imobiliário; Redes Neurais Artificiais; Previsão; Análise de Dados; Investimentos.
INFLUENCE OF FARMER MARKETING STRATEGIES AND WATER USERS ASSOCIATIONS ON PERFORMANCE OF SMALLHOLDER IRRIGATION PROJECTS IN MIGORI COUNTY, KENYA
Authors: Asawo Leopold Othieno , Aseey Anne Achieng , Chandi John Rugendo
Published: November 2024

Objective: The objective of this study was to investigate influence of farmer marketing strategies and water users associations on performance of smallholder irrigation projects, and was aimed at enhancing smallholder irrigation project outcome success in Migori County, Kenya.
 
Theoretical Framework: The study was anchored on market orientation theory by Kohli and Jaworski (1990) and Narver and Slater (1990). This is because market orientation explains relationship between markets and organisational behaviour (Gotteland et al., 2007). Kohli and Jaworski (1990) explain customer needs, market competition and usefulness of a product as interacting to influence its marketability.
 
Method: Using cross-sectional and correlational research design, the study collected data from 341 farmers out of a target population of 2815 in 15 smallholder irrigation projects in Migori County using a 5-Point Likert Scale questionnaire. The data was analysed using descriptive and inferential statistics.
 
Results and Discussion: The results show that farmer marketing strategies accounts for 64.1% of findings in the model, with group marketing having the most significant influence on performance. The results also show that introduction of water users associations increases coefficient of determination (Δr2) by + 0.121, indicating a positive modest moderating influence on the relationship between predictor and dependent variables.
 
Research Implications: The study confirms that farmer marketing strategies influence performance of smallholder irrigation projects, and that water users associations positively but modestly influence the relationship. Empirically, the study highlights the importance of cooperative societies, agro-processing and irrigation management transfer in smallholder irrigation.
 
Originality/Value: This study adds to empirical data on farmer marketing strategies, water users associations and smallholder irrigation. In highlighting these aspects, the findings have potential to benefit development agencies in smallholder irrigation.
Assessing Graduateness in Higher Education Islamic Tertiary Institutions in South Africa: Towards a Pedagogical Contextual Approach
Authors: Al-Sowaidi Belqes , Mohammed Tawffeek A. S.
Published: November 2024

This study aims to examine the concept of graduateness in tertiary Islamic institutions and its essential integration into the curriculum of Islamic higher education. The study sheds light on the connections between program content, teaching methodologies, and the cultivation of graduateness in the context of Islamic education at the International Peace College South Africa (IPSA), emphasizing the curriculum’s role in enhancing values and ethics alongside employability preparedness. The study investigates the BA program at IPSA over three years (2020-2023). Employing the frameworks of Coetzee’s categorization of Graduate Attributes, Biggs’ Constructive Alignment, and the Technological Pedagogical Content Knowledge (TPACK), the analysis explores attitudes toward curriculum content, teaching, and learning through the lens of graduateness development. Results from the questionnaire revealed a statistically significant difference in the development of graduate attributes at IPSA, influenced notably by thematic content (p = 0.0018). In addition, there was a strong correlation between students’ and lecturers’ perceptions (r = 0.900, p < 0.0001), indicating effective alignment in the understanding of educational goals.
Exploring the Transformative Influence of Dramatic Arts Education on Academic Achievement and Personal Development of Grade 10 Students
Authors: Sincuba Limkani
Published: November 2024

This study examined how dramatic arts education affects students in Grade 10 through improving their academic performance and personal growth thereby changing their lives. Using interpretative paradigms based on social interpretative theoretical frameworks, the study used a mixed qualitative and quantitative research methodology. A questionnaire was used to collect data from a purposive sample of 120 Grade 10 dramatic arts students and seven teachers. The case study was conducted in two schools using a descriptive study methodology. An examination of the data showed strong correlations between involvement in the dramatic arts and academic achievement, and discernible behavioural and critical skill gains throughout a student's academic life. Results showed that, because of the topic matter covered, students of the dramatic arts modified their misbehaviours. The results demonstrated that dramatic arts is important for developing critical thinking, problem-solving, and practical communication skills. This study recommends that teachers receive training in dramatic arts teaching and that more students be enrolled in dramatic arts programmes. Even though students enjoy dramatic arts as a subject, the results of this study show that some students were concerned about getting parental approval to enrol in dramatic arts. The study emphasises the transformational potential of dramatic arts education in providing students with the necessary skills for coping in a rapidly shifting world and gives insightful recommendations for educators, legislators, and curriculum designers. The study concluded that studying dramatic arts benefits students’ academic performance and has a transformative effect on their personal lives. The study also found that parents greatly influenced the choice of dramatic arts as a subject taught in schools.
Synthesis, Crystal Structure and Spectral Characterization of 5-methyl-2-(propan-2-yl)cyclohexyl cyanoacetate and 1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl cyanoacetate
Authors: Mohamed F.S. , Bąkowicz J. , Dziuk B. , Nawwar G.A.
Published: November 2024

The titled compounds were synthesized using a conventional esterification method, involving the reaction of the desired alcohol with cyanoacetic acid. Single crystal was obtained through recrystallization. The compounds were characterized using elemental analysis, IR, ¹H NMR, ¹³C NMR spectroscopy, and mass spectrometry. The structural parameters, including bond distances and angles, were analyzed and discussed based on X-ray study result. The study revealed that the hydrogen atoms of the methylene groups in the two synthesized compounds exhibit a rigid C–H rotating group. The absolute configuration of the stereogenic centers in both compounds was consistent with the substrate used in their synthesis.
VRIO Analysis in Developing Branding Strategies for Egg-Based Food Products as Souvenirs from Blitar – Local Perspective
Authors: Utama Adiguna Sasama Wahyu , Wardani Shanti Ike , Putra Aditya Wirawantoro
Published: November 2024

Blitar is rich in tourism potential. The local economy stands to benefit significantly from tourism, creating job opportunities and enhancing community development. Blitar's position as a major egg producer offers unique opportunities for developing egg-based souvenirs. However, challenges include identifying appealing products and effective branding strategy is required to enhance the marketability of these products, fostering economic growth and tourism in the region. This study utilizes a mixed-method approach to explore consumer perceptions of egg-based processed products in Blitar, combining quantitative surveys with qualitative interviews of business actors. A survey of 61 respondents gathered measurable data on consumer preferences and factors influencing purchasing decisions. In-depth interviews provided insights into marketing strategies and challenges faced by producers. The study employs descriptive statistics and VRIO analysis to develop effective branding strategies for promoting processed egg products as signature souvenirs from. The analysis reveals that respondents indicating higher interest in egg-based products as souvenirs from Blitar as food significantly influences their choice of tourist destinations, with a strong preference for local ingredients. However, awareness of Blitar’s egg production potential is low, leading to limited appeal for egg-based products. The VRIO analysis shows organizational weaknesses hinder competitive advantage despite valuable product features. Effective branding strategies tailored to consumer expectations are crucial for market success. Enhancing product awareness and education through organized action can further strengthen the appeal of these culinary offerings in tourism.
THE FAMILY HISTORY OF THE GREAT TSAR. ON THE PUBLICATION OF A NEW STUDY
Authors:   Russian State University for the Humanities, Pchelov Evgenii V.
Published: November 2024

The article analyzes a new monograph by N.Yu. Bolotina, A.Yu. Kononova and M.O. Bolotina “Peter the Great in the family circle. Research and Documents” (Moscow, 2023), published for the anniversary of Peter the Great. For the first time, the book reconstructs the family history for one of the most remarkable rulers of Russia, relying on a huge complex of historical sources, primarily archival documents. In great detail, the research recounts all the most important events in the personal life of the tsar, draws up the characterological and psychological portraits of his family members reveals the peculiarities of Peter I’s relationship with the relatives, traces the internal family conflicts and their origins. The book provides the answers to many specific questions about the biographies and genealogy of the Romanov dynasty of the late 17th – first quarter of the 18th centuries. The study defines the exact dates of the persons’ lives, reveals the naming traditions, presents the story of childhood in the royal family, shows the level of education and describes the circumstances of life. The book also contains a current publication of more than 300 different sources, many of which are introduced into the scientific circulation for the first time. Another important part consists of the consolidated list of the epistolary heritage of the Peter I’s family; it contains almost one and a half thousand records, including unpublished letters. The book contributes immensely to the study of the dynastic and family history of the house of the Romanovs and will certainly rank among the largest scientific monographic studies of the Peter the Great era.
ICONOGRAPHY OF THE ROMAN LEGIONARIES’ SHIELDS OF THE LAST THIRD OF THE 2ND CENTURY AD: ON THE MATERIAL OF THE RELIEFS OF THE MARCUS AURELIUS COLUMN
Authors:   Russian State University for the Humanities, Bazhenov Egor A.
Published: November 2024

The article considers the reliefs with the Roman legionnaires’ images on the Column of Marcus Aurelius as a source on the Roman weaponry and military tactics of the last third of the 2nd century AD. Traditionally in historiography, those images are not considered sufficiently representative due to the large number of the borrowings from other monuments of the Roman triumphal art. By analyzing the images of various legionary shields on the Marcus Aurelius Column and comparing them with other monuments of the Roman art of the last third of the 2nd – early 3d centuries AD, there were similarities found between them in representing the elements of the Roman military equipment. The Column images prove the use by the legionnaires of at least four types of shields with various shapes. It is also assumed that Roman soldiers could have used the shields of different shapes and types even within the same formation or the formation without any reference to a particular line of formation construction. In general, the reliefs of the column make it possible to challenge the conventional wisdom of the uniform armament of the Roman legions during the period of the Principate. Thus, the reliefs of the Column of Marcus Aurelius can be considered a valuable source on the military affairs of the early Empire era.
THE ISSUE OF RELIGION IN CONNECTION WITH PUBLIC EDUCATION AS AN ELEMENT OF THE ADMINISTRATIVE MANAGEMENT SYSTEM IN THE KYRGYZ INNER HORDE IN THE SECOND HALF OF THE 19TH CENTURY
Authors:   Kalmyk Scientific Center, Russian Academy of Sciences, Gunaev Evgenii A.
Published: November 2024

This article examines the issue of religion in relation to the issue of public education in the Kyrgyz Inner Horde in the second half of the 19th century. The inevitable introduction of Russian schools, which embodied the civic model of education, led to a competition between Islamic and civic education. Islamic education in the Kazakh steppe was initially based on the activities of Tatar mullahs. By the example of the document from the F.K. Girs’s Commission of 1873 and the information reflected in the publications by pre-revolutionary researchers A.E. Alektorov and A.N. Kharusina on school education and religious life in the Inner Horde, it is shown that, over time, the Tatar influence was recognized by the imperial authorities as undesirable and contrary to the goals of developing the civicmindedness among the Kazakhs, to the unity with the Russian ethnic group and to the building of a united civil nation. In that regard, the projects of certain restrictive measures against the “Tatar education”, as well as protectionism in the trade sphere, began to be put forward. At the same time, two contradictory trends seem to be visible in the historical development of the Kyrgyz Inner Horde: on the one hand, it was the initiation of European education resulting in the construction of the schools with Russian language teaching, and, on the other hand, there was an increased introduction of Islam into the daily life of Kazakhs by Dzhanger Khan. The field of education needed constant care from the state and local authorities in order to carry out an effective acculturation policy among the nomadic aliens. One of the measures was seen in the increase of government schools practiсing teaching in Russian with the inclusion in the curriculum of the native Kazakh language and the Mohammedan teachings.
EFFECT OF YOGIC PRACTICES WITH AND WITHOUT WALKING ON SELECTED PSYCHOLOGICAL VARIABLE AMONG WOMEN SENIOR CITIZENS
Authors: Vasudevan P. Sanmugapriya
Published: November 2024

Old Age is a natural part of the life cycle. All living organism including humans undergo the process from conception to infancy, child hood puberty, maturity and senescence. Longer life means more frailty and more disability. Apart from economic problem they face in their life, the common diseases like ortho, visual, audio and mental some face grave diseases of heart, blood etc. The care of old people in a separate branch of medicine called Geriatrics and scientific study of old age and process of growing old is called Gerontology. The definition of ageing varies from society to society and has been modified considerably over time. The purpose of this study was to find out the effect of Yogic practices with and without Walking  on selected Psychological variable  in Women senior citizens. The selected subjects 45 were randomly divided into three groups equally of which experimental Group – I underwent yogic practices with Walking, Group – II underwent yogic practices without Walking Group – II acted as Control Group. The subjects selected for this study were in the age group of above 60 years. Each group consisting of fifteen subjects, there experimental group as Group I  & II and Control group as Group III. The following psychological variable was selected as dependent variables such as stress and the stress questionnaire constructed by Dr.Latha Satish (1997) consisting of 52 questions. , and the following variable was selected as independent variable as yogic practices and walking. The data collected on selected criterion variables were subjected to statistical analysis using analysis of covariance (ANCOVA) to find out any significant difference between the three groups on stress.
Moral Imagination for Engineering Teams: The Technomoral Scenario
Authors: Keeling Geoff , Lange Benjamin , McCroskery Amanda , Pedersen Kyle , Weinberger David , Zevenbergen Ben
Published: November 2024

“Moral imagination” is the capacity to register that one’s perspective on a decision-making situation is limited, and to imagine alternative perspectives that reveal new considerations or approaches. We have developed a Moral Imagination approach that aims to drive a culture of responsible innovation, ethical awareness, deliberation, decision-making, and commitment in organizations developing new technologies. We here present a case study that illustrates one key aspect of our approach – the technomoral scenario – as we have applied it in our work with product and engineering teams. Technomoral scenarios are fictional narratives that raise ethical issues surrounding the interaction between emerging technologies and society. Through facilitated roleplaying and discussion, participants are prompted to examine their own intentions, articulate justifications for actions, and consider the impact of decisions on various stakeholders. This process helps developers to reenvision their choices and responsibilities, ultimately contributing to a culture of responsible innovation
An Investigation into Secondary School Students' Skills in Using Symbols, Operations, Concepts and Rules in Mathematical Modeling Applications
Authors: Yıldırım Uğur , Bekdemir Mehmet
Published: November 2024

This study aims to examine the symbols, operations, rules and generalizations used by sixth grade students in mathematical modeling processes. Using the Teaching Experiment method, data was collected through student worksheets and video recordings. Analyzes showed that students correctly used previously learned symbols such as +, =, /, discovered new symbols, and applied their own strategies during modelling. Mathematical modeling activities helped students make interdisciplinary connections and relate concepts to daily life. The students correctly used the concepts they had previously learned and discovered new concepts, but it was determined that they needed more time and practice to generalize. The study emphasizes the importance of applying mathematical modeling activities frequently and with a variety of topics.
Investigation of Duolingo-Music in Terms of Universal Design for Learning and Gamification Components
Authors: Sever Gülşah , Dağhan Berivan , Böke Sefa
Published: November 2024

This study aims to analyze the music module of the Duolingo application in terms of universal design of learning (UDL) and educational game components. The research was carried out using an evaluative design within qualitative research methods. Universal Design Principles Checklist and Educational Gamification Elements Identification Form were the data collection tools. The application was subjected to a detailed evaluation by three experts specialized in music education and gamification. According to the results, the Duolingo music application was mainly based on the principles of UDL and educational game components. It was determined that 37 of the 45 items within the UDL principles were met by the application, and its compliance with universal design principles was generally high. However, it was determined that some areas had the potential for improvement. In particular, it was emphasized that improvements should be made in features such as content customization, user control, and alternative keyboard compatibility. When the application was examined in terms of educational game components, it was seen that some features, such as customizable avatars and leaderboards, were available, as well as visual or auditory feedback. However, the lack of narrative tasks and in-game teams shows that the application must also be improved. In conclusion, it has been determined that Duolingo's music application has strengths and areas that need improvement. Therefore, it is recommended that the application be evaluated experimentally in future studies. Such studies can help us better understand the application's effectiveness and learning outcomes. In addition, suggestions can be developed to improve the user experience and create a more effective learning environment.
Perkembangan targeted therapy pada kanker payudara dengan pertimbangan luaran biaya dan kualitas hidup: narrative review
Authors: Puspitasari Candra Eka , Annisa Janatul , Yasykurah Malva Marshaniswa , Hawarikatun Baiq
Published: November 2024

Breast cancer is a malignant tumour that grows in the breast tissue and can spread to the lymph nodes and metastasize to other parts of the body. Targeted therapy is currently developed as a therapeutic management for breast cancer with hormone receptor positive/human epidermal growth factor receptor 2 negative (HR+/HER2-). This review aims to determine the effectiveness both in terms of clinical and cost on the use of single or combined targeted therapy when compared with conventional therapy, namely chemotherapy in breast cancer patients. The results show that the use of targeted therapy can provide greater health benefits in both single and combination use even though it can increase the cost of therapy.
Atletismo Impacto na Saúde Física e Mental e o Desenvolvimento da Técnica Esportiva
Authors: mello Eliete reis de
Published: November 2024

O atletismo, uma das modalidades mais antigas e difundidas no esporte, possui um papel significativo tanto no desenvolvimento físico quanto no bem-estar psicológico dos praticantes. Este artigo explora os principais benefícios da prática regular de atividades de atletismo, abordando sua contribuição para a saúde cardiovascular, a resistência física e a força muscular. Além disso, o texto discute as implicações mentais e emocionais, bem como a evolução e o desenvolvimento técnico ao longo do tempo. A partir de uma revisão de literatura e dados de pesquisa, o artigo pretende destacar a relevância do atletismo como prática educativa e competitiva.
Etapas do populismo na América Latina
Authors: Lima Matheus Silveira
Published: November 2024

O presente artigo apresenta três momentos marcantes do populismo, em que duas ideias merecem ser esclarecidas mais a fundo: o populismo se desenvolve na América Latina como possibilidade de modernização, tornada possível através da mudança de eixo dos mecanismos de dominação, do velho colonialismo europeu, para o capitalismo financeiro norte-americano. A outra questão diz respeito à correlação entre o populismo e o patrimonialismo, na medida em que ambos trazem progressos, mas se “congelam” e tornam-se empecilhos para novos avanços, especialmente no que diz respeito ao fortalecimento da sociedade civil organizada. Por isso, em grande medida, passam a receber uma leitura conceitual e acadêmica bastante negativa. Nesse sentido, entender o populismo é fazer permanentemente um movimento histórico, de idas e vindas, entre política e economia, para compreender a América Latina em suas especificidades, seus descarrilamentos e retomadas aceleradas de movimento em busca de um futuro idealizado.
DETERMINADO DO VOLUME DE AR NO "CUFF" DE SONDAS ENDOTRAQUEAIS
Authors: KARAN BARBOSA PEDRO MARCO , DE OLIVEIRA SANTOS BRANCA MARIA
Published: November 2024

O objetivo deste estudo foi determinar o melhor ajuste do volume de ar a ser insuflado no “cuff” de diferentes diámetros de cánulas endotraqueais de alto volume residual e baixa pressao, mantendo a pressáo exercida pelo balonete na mucosa da traquéia entre os limites preconizados de 20 a 30 mmHg (menor que a pressáo capilar da traquéia). Para tanto foi insuflado 10 mi de ar no "cuff” de cánulas de pacientes intubados com diferentes diámetros internos (7,0 - 7,5 - 8,0 - 8,5 - 9,0), urna a urna, mensurando a cada mi de ar insuflado, a pressáo correspondente do “cuff" na mucosa da traquéia. A monitoraqáo da pressáo foi realizada através de um manómetro previamente calibrado. O procedimento foi realizado em 25 pacientes adultos, de ambos os sexos, agrupados em número de 5, para cada diámetro interno de cánula. Os resultados obtidos foram analisados através da análise de regressáo linear que demonstrou a relaáo aproximada entre mlar insuflado, pressáo do “cuff", por diámetro de cánula. Após análise dos resultados os autores construíram um quadro com a indicaqáo da quantidade de ar a ser insuflado no balonete e a respectiva pressáo exercida sobre a mucosa da traquéia, por diámetro de cánula, oferecendo urna contribuiqáo para o pessoal que presta assisténcia á pacientes intubados, no sentido de minimizar os possíveis daños e complicaqóes e assegurar urna melhor ventilaqáo respiratoria.
PERCEPCION DE INCERTIDUMBRE DE LOS PACIENTES DIABETICOS, CONTROLADOS EN EL CONSULTORIO ADOSADO DE ESPECIALIDADES, DEL HOSPITAL HERMINDA MARTIN DE CHILLAN, CHILE, 1994-1995
Authors: ISLA LUND XIMENA
Published: November 2024

El propósito de este estudio de tipo explicativo fue evaluar la percepción de Incertidumbre de los pacientes con Diabetes Mellitus que se encuentran en control y los factores que influyen en este proceso para explicar y predecir el grado de asociación existente. El grupo de estudio lo constituyeron 115 pacientes con Diabetes Mellitus, controlados en el Consultorio, Adosado de Especialidades del Hospital Herminda Martin de Chillán, Chile, durante los meses de diciembre 1994 a febrero de 1995. Esta investigación se basó en la Teoría de Incertidumbre de Merle Mishel, aplicando la Escala de Incertidumbre para la Enfermedad de Mishel (MUIS). Los resultados relacionaron en forma estadísticamente significativa percepción de incertidumbre con nivel educacional, nivel de ingresos familiares, grado de conocimiento acerca de la enfermedad y nivel de Autoestima.
ESTUDIO COMPARATIVO DE RESPUESTA NEUROENDOCRINA Y PSICOLOGICA DE STRESS
Authors: STIEPOVICH BERTONI JASNA , NAVEAS GONZALEZ RINA
Published: November 2024

Investigación de análisis secundario, cuyo propósito fue indagar si existe relación entre parámetros neuroendocrinos que se liberan en situaciones de stress y percepción cognitiva de stress que tiene la persona al enfrentar el mismo estímulo de alarma, que en el presente trabajo correspondió al examen de arteriografía coronaria. N = 28 pacientes. Se plantearon hipótesis que relacionan puntaje de escala termómetro del miedo con niveles plasmáticos de noradrenalina plasmática, glicemia y cortisol, en pacientes que se enfrentan a una arteriografía coronaria. Se trabajó con datos recolectados en investigación "Intervención de Enfermería como estrategia para reducir el Stress frente a una Arteriografía Coronaria". El stress fue medido por niveles: noradrenalina plasmática, glicemia,cortisol y escala termómetro del miedo (Walk 1956). Se trabajó con décimas no paramétricas, coeficientes de correlación de Spearman y Kendall. Resultados permiten destacar que no existe correlación positiva entre puntajes de escala termómetro del miedo y niveles plasmáticos de noradrenalina, glicemia y cortisol. Concluyendo que la escala termómetro del miedo no es un instrumento de medición recomendable para medir stress.
AREAS Y LINEAS, GRUPOS Y CENTROS DE INVESTIGACION EN EL DESARROLLO DEL CONOCIMIENTO DE ENFERMERIA
Authors: VELANDIA MORA ANA LUISA
Published: November 2024

Inicialmente se hace alguna conceptualización a manera de introducción al tema: el conocimiento y la investigación, los sujetos (actores) de la investigación, papel de los Doctorados en Enfermería y la investigación como condición necesaria para un Doctorado en Enfermería. La parte central está dada por algunos aspectos definitorios del tema como: indicadores de ciencia y tecnología, estilos de producción científica, la investigación y el desarrollo científico - tecnológico; y por el núcleo temático del escrito: Areas y Líneas de Investigación, su conceptualización y definición; Grupos y Centros de Investigación, conceptualización y definición, características de un Grupo de Excelencia e indicadores para la evaluación del mismo; y finalmente se hace la presentación de algunas experiencias en enfermería, concretamente una en Colombia y otra en el Brasil.