bluuebunny/crossref_metadata_2025 huggingface dataset:
Enantioselective Synthesis, Computational Molecular Docking and In Vitro
Anticoagulant Activity of Warfarin-based Derivatives
Authors: Afzal Zakia , Rashid Naghmana , Nadeem Humaira , Khan Arif-Ullah , Ashraf Zaman
Published: December 2023

Warfarin containing a 4-hydroxycoumarin moiety possesses excellent anticoagulant
activity, with the (S) enantiomer being the eutomer. The present work is designed to
synthesize warfarin based derivatives enantioselectivity to explore their anticoagulant potential.
The substituted chalcones were reacted with 4-hydroxycoumarin in the presence of
the chiral organocatalyst 9-amino-9-deoxyepiquinine to afford warfarin-based analogues 5a-
5k. The structures of synthesized compounds 5a-5k were confirmed by Fourier transform
infrared spectroscopy (FTIR), proton nuclear magnetic resonance spectroscopy (1H NMR),
carbon-13 nuclear magnetic resonance spectroscopy (13C NMR) and electron ionization
mass spectroscopy (EIMS) data. The enantiomeric excess (ee) has been found in the range
of 16-99% as determined by chiral high-performance liquid chromatography (HPLC) analysis.
The in vitro anticoagulant activity of the products 5a-5k was evaluated by plasma recalcification time (PRT)
method, and it was found that most of the derivatives showed good anticoagulant activity, specifically compound
5b exhibited excellent results compared to that of warfarin. Compound 5b displayed an IC50 value of
249.88 μM, which is better than that of warfarin (IC50 408.70 μM). The molecular docking studies have been
performed against vitamin K epoxide reductase with PDBID 3kp9. The synthesized compounds bind well in the
active binding site of the target enzyme. The derivative 5b showed π-π stacking interactions with the amino acid
phenylalanine (Phe 114). The antimicrobial activity of synthesized compounds has also been evaluated, and
results showed moderate antimicrobial activity. Based on our results, it is proposed that derivative 5b may act as
a lead compound to design more potent anticoagulant derivatives.
Anti-inflammatory Effect of Novel 2-Phenylphthalazin-2-ium Bromides on LPS-induced RAW264.7 Cells and their Mechanism
Authors: Cao Fang-Jun , Shen Jian , Zhang Hui , Wang Lu
Published: December 2023

Background:

Inspired by natural anti-inflammatory quaternary benzo[C]phenanthridine
alkaloids, novel 2-phenylphthalazin-2-ium bromides were previously designed and synthesized.

Objective:

The anti-inflammatory effect of 2-phenylphthalazin-2-ium bromides was evaluated based
on inflammatory cytokines, and their possible mechanism was explored through the NF-κB, TLR4
and MAPK signaling pathways.

Methods:

The tested concentrations of two compounds were assessed using MTT assay in vitro.
Griess assay was used to determine the changes in nitric oxide (NO) in the cell culture supernatant.
qRT‒PCR was used to detect the mRNA levels of inflammatory cytokines, such as IL-6, IL-1ß, IL-10,
TNF-α, TLR4 and iNOS. The secretion levels of TNF-α and IL-1β were detected by ELISA. Western
blot test was used to detect the protein expression of IL-6, IL-10, TLR4, iNOS, NF-κB, p-P38/P38, p-
ERK/ERK and p-JNK/JNK.

Results:

2-(3,5-Dichlorophenyl)phthalazin-2-ium bromide (2) with a concentration below 1 μg/mL
showed no significant effect on the growth inhibition of RAW264.7 cells, so the concentrations of
compound 2 used for experiments were set to 0, 0.25, 0.5 and 1 μg/mL. Compared with the blank
control group, the model group showed increased release of NO, transcription levels of IL-6, IL-1ß,
IL-10, TNF-α, TLR4 and iNOS (p<0.05), and ratios of p-P38/P38, p-ERK/ERK, p-JNK/JNK
(p<0.05). Compared with the model group, the sample groups displayed decreased NO release and
reduced transcriptional levels of IL-6, IL-1ß, IL-10, TNF-α, TLR4, and iNOS and reduced protein
expression ratios of IL-6, IL-1ß, IL-10, TNF-α, NF-κB, TLR4, iNOS, p-P38/P38, p-ERK/ERK and p-
JNK/JNK (p<0.05).

Conclusion:

This study showed that 2-phenylphthalazin-2-ium bromides partially protected macrophages
from the LPS-induced inflammatory response by suppressing TLR4-NF-κB/MAPK signaling
and reducing NO production.
Comparing Continuity of Midwifery Care Model with the Mother-child Health Book: Enhancing Knowledge for Adolescent Pregnancy in Indonesia
Authors: Susanti Dewi , Hardisman  , Yusrawati  , Mudjiran  , Machmud Rizanda , Nursal Dien Gusta Anggraini , Maputra Yantri , Hasnita Evi
Published: December 2023

Introduction:

Adolescent pregnancy poses a significant concern in Indonesia, particularly in some regions, namely West Sumatra and Padang City. This issue has been addressed with two prominent approaches, the Continuity of Midwifery Care (CMC) model and the Mother-Child Health (MCH) Book.

Objective:

This study aims to compare the effectiveness of these approaches in enhancing knowledge about adolescent Pregnancy, including several aspects, such as domestic violence, substance risks, reproductive health, pregnancy, childbirth, and parenting roles.

Material and Methods:

A quantitative research approach was applied by utilizing a quasi-experimental design, conducting pre- and post-tests with the validated questionnaires during the third trimester of pregnancy, postpartum days 31 and 43. Conducted in Padang City, the research involved 70 young primiparous mothers, categorized into groups using the CMC model and MCH Book. The collected data analyzed the generalized linear models repeated measures.

Results:

Both groups exhibited a significant knowledge enhancement, with the CMC model yielding more substantial enhancement. The focused and continuous care approach in the CMC model effectively enhanced the knowledge across various aspects, compared to the MCH Book.

Conclusion:

The CMC model stands out as an effective means to enhance knowledge among young pregnant mothers, addressing their distinct challenges during their transition to parenthood. We suggest that the health authorities and policymakers consider the implementation of the CMC model alongside the existing MCH book as a more effective approach to enhance the knowledge of Adolescent mothers.
Screening the Effectiveness of Kabasura Kudineer against COVID 19 and
Immune Proteins in Humans: In silico
Authors: Vijayalakshmi Architha , Srinivasan Hemalatha
Published: December 2023

Background:

The advent of severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) triggered a pandemic known as coronavirus disease 2019 (COVID-19) in the twenty-first
century. Recent research has revealed several details about SARS-CoV-2 pathogenesis, which has
greatly boosted research on COVID-19 vaccines and therapy methods for all the COVID variants.
However, significant doubts about its treatment persist due to its fast mutating capability and its resistance to various drugs administered. Thus, there is a need for a cure to treat all the variants and
their side effects.

Objective:

The main aim of this study is to check 1) the effectiveness of Kabasura Kudineer against
COVID 19 2) the side effects of Kabasura Kudineer with the help of immune proteins in humans

Methods:

The molecular docking was carried out between SARS-CoV-2 proteins and immune proteins in humans against Kabasura Kudineer compounds. The ADMET was also carried out to check
the Pharmacokinetics.

Results:

The results showed that chebulagic acid from Terminalia chebula has good binding capability with all the chosen targets1. The drug likeliness screening also proved it a good drug candidate.

Conclusion:

Siddha way of treatment has popped out which has been traditionally used for the
treatment of viral respiratory infections. The formulation called Kabasura Kudineer has been proven
to have antiviral agents and compounds that boost the immune system
Aprendizagens no cuidado informal: Uma análise reflexiva do Estatuto do Cuidador Informal e de experiências de cuidadores/as informais
Authors: Moura Ana , Castanheira Pais Sofia , Alves Elisabete
Published: December 2023

Embora as consequências do trabalho não remunerado de reprodução social tenham sido debatidas nos últimos anos, foi apenas em 2019 que os/as cuidadores/as informais romperam a “clandestinidade legal”, através da aprovação do Estatuto do Cuidador Informal. Apesar do inegável contributo deste estatuto, são várias as fragilidades apontadas, questionando-se essencialmente a falta de apoios económicos e sociais. Contudo, a problematização do lugar dos processos, recursos e serviços educativos na vida dos/as cuidadores/as informais raramente tem sido abordada, apesar das evidentes necessidades de aprendizagem deste papel. Tendo por base uma análise reflexiva da primeira autora, enquanto entrevistadora de cuidadores/as informais de sobreviventes de AVC, pretende-se explorar o lugar e o papel da educação no Estatuto do Cuidador Informal, assim como as perceções de cuidadores/as acerca deste documento legal e dos seus processos de aprendizagem. Este trabalho evidencia o hiato entre o texto político e a realidade dos/as cuidadores/as, vertendo-se no desconhecimento acerca das medidas e serviços de apoio. Embora esteja previsto o direito à (in)formação, é relatada a escassez de recursos e serviços educativos. Assim, as aprendizagens acontecem num plano experiencial, de forma inconsciente, autónoma e pouco suportada, podendo contribuir para desigualdades no campo do cuidado. Considerando a centralidade das aprendizagens ao longo da trajetória do cuidado, assim como a sobrecarga física e emocional deste papel, é essencial que políticas e práticas suportem os processos de aprendizagem dos/as cuidadores/as e que contribuam para a sua literacia e consciência cívica.
"Ikke annet våpen enn ord og tanke" ─ Peder W. Cappelens schauspiel Lòke
Authors: Schulz Katja
Published: December 2023

The writer Peder W. Cappelen (1931-1992), although one of the most prolific Norwegian playwrights of the 1960s to 1980s, is little known abroad and has also received little attention from Norwegian literary historians. One of the reasons may be that he was considered an apolitical poet in an era that had once again taken up the banner of putting problems up for debate and taking a political standpoint, and that as a playwright he mainly took up material from folk poetry or medieval literature. Using the example of his 1972 myth drama Lòke, I would like to show that, on the contrary, Cappellen very clearly takes up contemporary political and social issues in this play. The fact that the play was not more successful is rather due to the new realism of Norwegian literature in the 1970s. With his myth drama and especially with the constellation of characters in it, which assigns Lòke the role of a mediator, Cappelen proved to be ahead of his time, because in the 1980s there are a number of myth adaptations that make use of Loki's potential to overcome dualisms such as that between gods and giants.
Contactless Monitoring System Versus Gold Standard for Respiratory Rate Monitoring in Emergency Department Patients: Pilot Comparison Study
Authors: Goldfine Charlotte E , Oshim Md Farhan Tasnim , Chapman Brittany P , Ganesan Deepak , Rahman Tauhidur , Carreiro Stephanie P
Published: December 2023

Background

Respiratory rate is a crucial indicator of disease severity yet is the most neglected vital sign. Subtle changes in respiratory rate may be the first sign of clinical deterioration in a variety of disease states. Current methods of respiratory rate monitoring are labor-intensive and sensitive to motion artifacts, which often leads to inaccurate readings or underreporting; therefore, new methods of respiratory monitoring are needed. The PulsON 440 (P440; TSDR Ultra Wideband Radios and Radars) radar module is a contactless sensor that uses an ultrawideband impulse radar to detect respiratory rate. It has previously demonstrated accuracy in a laboratory setting and may be a useful alternative for contactless respiratory monitoring in clinical settings; however, it has not yet been validated in a clinical setting.

Objective

The goal of this study was to (1) compare the P440 radar module to gold standard manual respiratory rate monitoring and standard of care telemetry respiratory monitoring through transthoracic impedance plethysmography and (2) compare the P440 radar to gold standard measurements of respiratory rate in subgroups based on sex and disease state.

Methods

This was a pilot study of adults aged 18 years or older being monitored in the emergency department. Participants were monitored with the P440 radar module for 2 hours and had gold standard (manual respiratory counting) and standard of care (telemetry) respiratory rates recorded at 15-minute intervals during that time. Respiratory rates between the P440, gold standard, and standard telemetry were compared using Bland-Altman plots and intraclass correlation coefficients.

Results

A total of 14 participants were enrolled in the study. The P440 and gold standard Bland-Altman analysis showed a bias of –0.76 (–11.16 to 9.65) and an intraclass correlation coefficient of 0.38 (95% CI 0.06-0.60). The P440 and gold standard had the best agreement at normal physiologic respiratory rates. There was no change in agreement between the P440 and the gold standard when grouped by admitting diagnosis or sex.

Conclusions

Although the P440 did not have statistically significant agreement with gold standard respiratory rate monitoring, it did show a trend of increased agreement in the normal physiologic range, overestimating at low respiratory rates, and underestimating at high respiratory rates. This trend is important for adjusting future models to be able to accurately detect respiratory rates. Once validated, the contactless respiratory monitor provides a unique solution for monitoring patients in a variety of settings.
Navigating the Pedagogical Landscape: Exploring the Implications of AI and Chatbots in Nursing Education
Authors: Srinivasan Muthuvenkatachalam , Venugopal Ambili , Venkatesan Latha , Kumar Rajesh
Published: December 2023

This viewpoint paper explores the pedagogical implications of artificial intelligence (AI) and AI-based chatbots such as ChatGPT in nursing education, examining their potential uses, benefits, challenges, and ethical considerations. AI and chatbots offer transformative opportunities for nursing education, such as personalized learning, simulation and practice, accessible learning, and improved efficiency. They have the potential to increase student engagement and motivation, enhance learning outcomes, and augment teacher support. However, the integration of these technologies also raises ethical considerations, such as privacy, confidentiality, and bias. The viewpoint paper provides a comprehensive overview of the current state of AI and chatbots in nursing education, offering insights into best practices and guidelines for their integration. By examining the impact of AI and ChatGPT on student learning, engagement, and teacher effectiveness and efficiency, this review aims to contribute to the ongoing discussion on the use of AI and chatbots in nursing education and provide recommendations for future research and development in the field.
Effect of Baduanjin Qigong on Sleep Quality and Hyperarousal State in Adults With Chronic Insomnia: Protocol for a Randomized Controlled Trial
Authors: Xie Chaoqun , Xie Fangfang , Ma Jianwen , Yue Hongyu , You Yanli , Yao Fei
Published: December 2023

Background

Chronic insomnia (CI) is a mind-body disease that is commonly defined as a state of having disturbed daytime activities due to poor nighttime sleep quality. Baduanjin qigong (BDJQG) is widely used for CI in China. However, there is little scientific evidence to evaluate its effects on the hyperarousal state, which is closely associated with improved sleep quality.

Objective

The objective of the trial is to assess the therapeutic effects of BDJQG on sleep quality in patients with CI.

Methods

A randomized controlled trial will be conducted on 86 patients, who will be divided into a BDJQG group and a cognitive behavioral therapy for insomnia group at a ratio of 1:1. Interventions in both groups will be given to the participants 7 times a week for 8 weeks, and the participants will be followed up for 4 weeks. The primary outcome is the change in the Pittsburgh Sleep Quality Index from baseline to week 8. The secondary outcomes are the changes in the Hyperarousal Scale, Insomnia Severity Index, Fatigue Scale-14, wrist actigraphy, salivary cortisol level, and functional magnetic resonance imaging from baseline to week 8. All main analyses will be carried out on the basis of the intention-to-treat principle.

Results

This study was funded from January 2023. As of the submission of the manuscript, there were 86 participants. Data collection began in April 2023 and will end in January 2024. Data analysis is expected to begin in January 2024, with the publication of results expected in February 2024.

Conclusions

This study will present data concerning the clinical effects of BDJQG on CI. The results will help to demonstrate whether BDJQG is an effective therapy for improving sleep quality in association with a decreased hyperarousal level as a possible underlying mechanism. This study will provide much-needed knowledge for complementary and alternative therapy for patients with CI.

Trial Registration

China Clinical Registration Agency ChiCTR2300069241; https://chictr.org.cn/bin/project/ChiCTR2300069241

International Registered Report Identifier (IRRID)

PRR1-10.2196/53501
Quality Assessment of Smartphone Medication Management Apps in France: Systematic Search (Preprint)
Authors: Toïgo Mickael , Marc Julie , Hayot Maurice , Moulis Lionel , Carbonnel Francois
Published: December 2023

BACKGROUND

Adherence to medication is estimated to be around 50% for chronically ill patients in high-income countries. Improving the effectiveness of adherence interventions could have a far greater impact on population health than any improvement in specific medical treatments. Mobile health (mHealth) is one of the most effective solutions for helping patients improve their medication intake, notably through the use of mobile apps with reminder systems. With more than 327,000 apps available in the mHealth field, it is difficult for health care professionals and patients alike to choose which apps to recommend and use.

OBJECTIVE

We aim to carry out a systematic search of medication management smartphone apps available in France that send reminders to patients and assess their quality using a validated scale.

METHODS

Mobile apps were identified in October and November 2022 after a systematic keyword search on the 2 main app download platforms: App Store (Apple Inc) and Google Play Store. Inclusion criteria were free availability, date of last update, and availability in French. Next, 2 health care professionals independently evaluated the included apps using the French version of the Mobile App Rating Scale (MARS-F), an objective scoring system validated for assessing the overall quality of apps in the mHealth field. An intraclass correlation coefficient was calculated to determine interrater reliability.

RESULTS

In total, 960 apps were identified and 49 were selected (25 from the App Store and 24 from the Google Play Store). Interrater reliability was excellent (intraclass correlation coefficient 0.92; 95% CI 0.87-0.95; P<.001). The average MARS-F score was 3.56 (SD 0.49) for apps on the App Store and 3.51 (SD 0.46) for those on the Google Play Store, with 10 apps scoring above 4 out of 5. Further, 2 apps were tested in at least one randomized controlled trial and showed positive results. The 2 apps with the highest ratings were Mediteo rappel de médicaments (Mediteo GmbH) and TOM rappel medicaments, pilule (Innovation6 GmbH), available on both platforms. Each app’s MARS-F score was weakly correlated with user ratings on the App Store and moderately correlated on the Google Play Store.

CONCLUSIONS

To our knowledge, this is the first study that used a validated scoring system to evaluate medication management apps that send medication reminders. The quality of the apps was heterogeneous, with only 2 having been studied in a randomized controlled trial with positive results. The evaluation of apps in real-life conditions by patients is necessary to determine their acceptability and effectiveness. Certification of apps is also essential to help health care professionals and patients identify validated apps.
Association of Rest-Activity Rhythm and Risk of Developing Dementia or Mild Cognitive Impairment in the Middle-Aged and Older Population: Prospective Cohort Study (Preprint)
Authors: Haghayegh Shahab , Gao Chenlu , Sugg Elizabeth , Zheng Xi , Yang Hui-Wen , Saxena Richa , Rutter Martin K , Weedon Michael , Ibanez Agustin , Bennett David A , Li Peng , Gao Lei , Hu Kun
Published: December 2023

BACKGROUND

The relationship between 24-hour rest-activity rhythms (RARs) and risk for dementia or mild cognitive impairment (MCI) remains an area of growing interest. Previous studies were often limited by small sample sizes, short follow-ups, and older participants. More studies are required to fully explore the link between disrupted RARs and dementia or MCI in middle-aged and older adults.

OBJECTIVE

We leveraged the UK Biobank data to examine how RAR disturbances correlate with the risk of developing dementia and MCI in middle-aged and older adults.

METHODS

We analyzed the data of 91,517 UK Biobank participants aged between 43 and 79 years. Wrist actigraphy recordings were used to derive nonparametric RAR metrics, including the activity level of the most active 10-hour period (M10) and its midpoint, the activity level of the least active 5-hour period (L5) and its midpoint, relative amplitude (RA) of the 24-hour cycle [RA=(M10-L5)/(M10+L5)], interdaily stability, and intradaily variability, as well as the amplitude and acrophase of 24-hour rhythms (cosinor analysis). We used Cox proportional hazards models to examine the associations between baseline RAR and subsequent incidence of dementia or MCI, adjusting for demographic characteristics, comorbidities, lifestyle factors, shiftwork status, and genetic risk for Alzheimer's disease.

RESULTS

During the follow-up of up to 7.5 years, 555 participants developed MCI or dementia. The dementia or MCI risk increased for those with lower M10 activity (hazard ratio [HR] 1.28, 95% CI 1.14-1.44, per 1-SD decrease), higher L5 activity (HR 1.15, 95% CI 1.10-1.21, per 1-SD increase), lower RA (HR 1.23, 95% CI 1.16-1.29, per 1-SD decrease), lower amplitude (HR 1.32, 95% CI 1.17-1.49, per 1-SD decrease), and higher intradaily variability (HR 1.14, 95% CI 1.05-1.24, per 1-SD increase) as well as advanced L5 midpoint (HR 0.92, 95% CI 0.85-0.99, per 1-SD advance). These associations were similar in people aged <70 and >70 years, and in non–shift workers, and they were independent of genetic and cardiovascular risk factors. No significant associations were observed for M10 midpoint, interdaily stability, or acrophase.

CONCLUSIONS

Based on findings from a large sample of middle-to-older adults with objective RAR assessment and almost 8-years of follow-up, we suggest that suppressed and fragmented daily activity rhythms precede the onset of dementia or MCI and may serve as risk biomarkers for preclinical dementia in middle-aged and older adults.
Efficacy of the iJobs Web-Based Psychoeducational Intervention to Improve Job Search Behavior and Promote Mental Health Among Unemployed People: Protocol for a Waitlist Randomized Controlled Trial (Preprint)
Authors: Bodnaru Alexandra , Rusu Andrei , Vîrgă Delia , Van den Broeck Anja , Blonk Roland W B , Trancă Loredana Marcela , Iliescu Dragoș
Published: December 2023

BACKGROUND

Unemployment affects millions of people worldwide and, beyond its economic impact, has severe implications for people’s well-being and mental health. Different programs have been developed in response to this phenomenon, but to date, job-search interventions have proved to be most effective, especially the JOBS II program. The JOBS II program proved not only to be effective for re-employment but also has a positive impact on beneficiaries’ mental health (ie, reduces anxiety or depression). However, by now, this evidence-based program has been delivered only on site in the various countries where it was implemented. In the digital era, web-based alternatives to such programs are highly needed because they have the advantages of scalability and cost-effectiveness.

OBJECTIVE

In this context, we aim to investigate the efficacy of iJobs, the web-based adaptation of the JOBS II program, on job-search intensity and effort, the quality of job-search behaviors, and job-search self-efficacy. Further, 1 month after the intervention, we will also assess the employment status and the satisfaction with the job (if applicable). This study will also investigate the effect of iJobs on well-being and mental health (ie, anxiety and depression).

METHODS

This study is a 2-arm randomized controlled trial. The 2 independent groups (intervention vs waiting list control group) will be crossed with 3 measurement times (ie, baseline, the postintervention time point, and 1-month follow-up). The design will be a 2 (intervention vs control) × 3 (baseline, the postintervention time point, and 1-month follow-up) factorial design. iJobs is a 2-week intervention consisting of 6 modules: an introductive module and 5 modules adapted from the original JOBS II program to the web-based setting and Romanian population. The web-based intervention also has a human component, as beneficiaries receive personalized written feedback after each module on the platform from a team of psychologists involved in the project.

RESULTS

The enrollment of study participants started in June 2023 and is expected to end in May 2024. The data collection is expected to be completed by July 2024. The results are expected to be submitted for publication in the summer of 2024.

CONCLUSIONS

This study is the first large-scale randomized controlled trial aiming to test the efficacy of a web-based adaptation of the JOBS II program. If our results support the efficacy of iJobs, they will offer the premise for it to become an evidence-based, accessible alternative for unemployed people in Romania and might be implemented in other countries.

CLINICALTRIAL

ClinicalTrials.gov NCT05962554; https://clinicaltrials.gov/study/NCT05962554

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/55374
Evaluasi Penerapan Whistleblowing System dalam Mencegah Terjadinya Fraud: Studi Pada PT Bank Pembangunan Daerah Nusa Tenggara Timur
Authors: Radja Gae Dessy Juliantri , Maulana Aviandi Okta
Published: December 2023

Penelitian ini bertujuan untuk mengevaluasi pemanfaatan sistem whistleblowing di Bank NTT sebagai salah satu cara mencegah terjadinya fraud di perusahaan. Metode penelitian yang digunakan adalah kualitatif dengan pendekatan studi kasus untuk memperoleh informasi mendalam terkait penerapan dan pemanfaatan sistem whistleblowing di Bank NTT. Temuan penelitian menunjukkan bahwa penerapan sistem whistleblowing di Bank NTT terjadi karena adanya tekanan yang diberikan oleh regulator melalui peraturan yang diterbitkan berdasarkan Peraturan Otoritas Jasa Keuangan Republik Indonesia Nomor 39/POJK 03/2019. Penerapan sistem whistleblowing di Bank NTT juga terjadi karena adanya kepercayaan terhadap nilai moral dan budaya perusahaan. Tekanan dari organisasi sejenis yang telah menerapkan sistem whistleblowing tidak menjadi faktor yang menyebabkan Bank NTT menerapkan sistem whistleblowing. Sistem whistleblowing dinilai pihak internal sangat membantu perusahaan dalam mengungkap dan mencegah terjadinya fraud yang ada di lingkungan kerja dan unit bisnis yang dimiliki perusahaan. Hasil penelitian ini diharapkan dapat menjadi masukan bagi Bank NTT dalam memaksimalkan penggunaan sistem whistleblowing melalui pihak internal perusahaan.
MEDICAL STUDENTS’ EXPERIENCES WITH DYING PATIENTS: IDENTIFYING EDUCATIONAL NEEDS IN THE EASTERN CONTEXT
Authors: Dharmatika I Made Pramana , Suhoyo Yoyo , Prihatiningsih Titi Savitri
Published: December 2023

Background: The death of a patient is an event that could trigger medical students’ emotional reactions during clinical rotation. This study aimed to identify medical students’ preparedness in dealing with patients’ death and their educational needs through their lived experience.Methods: This was a qualitative study with a descriptive phenomenological approach. Purposive sampling was used to select medical students with experience caring for dying patients during clinical rotation. Data were collected through semi-structured interviews. Colaizzi’s method was used to analyze data.Results: The experience of six medical students showed medical students’ difficulties in discussing end-of-life with family members, giving emotional support to dying patients, and supporting grieving family members. Hierarchies and hidden curriculums influenced the interaction between medical students and medical staff during end-of-life care provision. The educational needs of medical students were teaching and learning about communication skills and attitudes in caring for dying patients, awareness of local culture in end-of-life care, the opportunity to observe medical staff communicate with dying patients and family members, and debriefing with healthcare team members after patients’ death.Conclusion: The findings of this study have provided insight into medical students’ experiences in dealing with patients’ death and their problems. Medical schools should prepare medical students to care for dying patients through curriculum development.
IMPROVEMENT OF STUDENTS’ KNOWLEDGE AND READINESS AFTER A SHORT COURSE PILOT OF IPE IN GERIATRIC CARE
Authors: Setiawan Ide Pustaka , Mawardi Fitriana , Riskiyana Rilani , Arjuna Tony , Samekto Perdana , Madyaningrum Ema , Anggraeni Vita Yanti , Ariwibowo Eko
Published: December 2023

Background: A five-day interprofessional education (IPE) pilot program in geriatric care was introduced to advanced students in clinical rotation. The program focused on providing students with interprofessional experience in managing elderly care. This study aimed to understand the knowledge, readiness, and perception of students from three different professional programs (medical, nursing, and health nutrition students regarding this pilot program Methods: A descriptive quantitative research with open-ended questions was conducted. Wilcoxon analysis was performed to find the difference in students' knowledge and readiness regarding interprofessional collaboration practice before and after the pilot program. Open-ended questions were distributed online to evaluate students' reflections upon participating in the program. Results: There were 27 participants consisting of 8 medical students, 10 nursing students, and 9 health nutrition students involved in this study. The quantitative study found an increase in interprofessional knowledge and readiness (p<0.001). There were also improvements in intra-professional knowledge of the medical, nursing, and dietetics students with p<0.001 in each profession. A descriptive analysis of open-ended questions revealed that teacher competence and good program coordination were regarded as important for the program's success. Students reported that they had a better understanding of the role of other professions in managing patients’ problems. Interprofessional communication was regarded as important to ensure patient safety. Students also learned that interprofessional collaboration in elderly care is important to improve the patient’s quality of life. Conclusion: The pilot IPE program improved both interprofessional and intra-professional knowledge and readiness of the students in geriatric clinical rotation. Moreover, students felt this activity had a positive impact on their understanding of interprofessional collaboration and patient health outcomes.
Evaluation of the Algerian pilot program of colorectal cancer screening by immunological test
Authors: Mazouzi Chahira , Benyahia Radia , Kerboua Esma , Belloul Meriem , Laoussati Malha , Cherif Mokhtar Hamdi , Bouzid Kamel
Published: December 2023

The results of various randomized clinical trials have led to the establishment of pilot or organized colorectal cancer screening programs in several countries. To date, there is no mass screening program or strategy for colorectal cancer in Algeria for the average risk population. Thus, our work problematic was composed: mainly on the feasibility of implementing a colorectal cancer screening program. The objective of our study is to carry out an organized mass screening strategy for colorectal cancers in the wilaya of Bejaia as a pilot project within the framework of the 2015-2019 cancer plan. The criterion of judgment of this program established is the Rate of participation (TP) of the target population which must be higher or equal to 40%. The program developed is evaluated by performance indicators. The participation rate was 30.02%. 17(6‰) people are screened for colorectal cancer. The mean age of his patients is 59.76 years +/- 8.2, a median of 57 years and a mode equal to 50 years.24.24% people with advanced adenomas.At the end of our study in this pilot wilaya designated by the 2015-2019 cancer plan, it appears that the organized screening program is feasible subject to the following conditions: - Expand the pilot phase of a population-based screening in other sites in Algeria. - Institutionalize the colorectal cancer screening program at the local and national levels. - Provide a dedicated budget for this project. - Create a colorectal cancer mortality registry at the regional and national levels
The Influence of Arbuscular Mycorrhizal Fungi (FMA) Dosage and Yomari Liquid Organic Fertilizer on the Growth of Seedlings of Agarwood-Producing Plants (Aquilaria malacensis Lamk.) on Former Gold Mining Soil”
Authors: Satria Benni , Martinsyah Rachmad Hersi , Armansyah Armansyah , Erona Meisilva , Warnita Warnita
Published: December 2023

Former gold mining land exhibits poor soil fertility, both biologically, chemically, and physically due to the damaging effects of the mining process on the land. Marginal land conditions, like former gold mining areas, necessitate high-viability seedlings. Efforts to acquire quality seeds and boost the productivity of this land involve planting adaptable and high-quality plant seeds, such as the agarwood-producing plant (Aquilaria malaccensis Lamk.). This plant is among the adaptive non-timber forest products that grow and naturally produce without inoculation (injection) on ex-mining lands—gold, nickel, rocky sand, tin, and coal—supplemented with liquid organic fertilizers like Yomari and Arbuscular Mycorrhizal Fungi (AMF) on Aquilaria malaccensis Lamk plants. Yomari liquid organic fertilizer, with its high organic and nutrient content, can enhance soil organisms, improve soil pH, while AMF can promote root growth and expansion, aiding roots in water and nutrient absorption through their external hyphae. Consequently, this facilitates the production of numerous and robust roots. This research aims to determine the optimal interaction between AMF doses and Yomari Liquid Organic Fertilizer for the growth of Aquilaria malaccensis Lamk seedlings in former gold mining land. Additionally, it seeks to ascertain the impact of administering the best Yomari organic fertilizer dosage and the best AMF dosage on the growth of Aquilaria malaccensis Lamk on ex-gold mining land. This research was conducted from June to November 2022 in the nursery of the Faculty of Agriculture, Andalas University. Employing a factorial experimental method in a Completely Randomized Design (CRD) with two factors—firstly, the AMF dose consisting of four levels: 10 grams (F1), 20 grams (F2), 30 grams (F3), and 40 grams (F4), and secondly, the Yomari organic fertilizer dosage comprising five levels: 0 ml (Y0), 0.75 ml/l (Y1), 1.5 ml/l (Y2), 2.25 ml/l (Y3), and 3.0 ml/l (Y4)—each treatment level comprised four replications. Qualitative and quantitative observation data were analyzed using the F-test at a 5% level of significance. Post-hoc analysis for differences among treatments was conducted using the BNT test at the 5% level. Observations included the percentage of live seeds, seed height increment, leaf number, widest leaf width, root weight, and percentage of roots infected by AMF in ex-gold mining soil media inoculated with Acaulospora sp. and Gigaspora sp. The administration of 40 grams of FMA with a dose of 3.00 ml/l of liquid organic fertilizer showed an increase in the percentage of survival, an increase in the number of leaves, an increase in the height of the plant seedlings, the widest leaf width, the percentage of root weight, and the seedlings of agarwood-producing plants infected with AMF.
Soberanía alimentaria y autoconsumo: estudio cualitativo sobre la población jornalera agrícola asentada en Miguel Alemán, Sonora
Authors: Arellano Gálvez María del Carmen
Published: December 2023

Objetivo: analizar las prácticas de autoconsumo como contribución a la soberanía alimentaria de la población jornalera agrícola asentada en Miguel Alemán, Sonora, México. Metodología: con enfoque etnográfico, entre agosto y noviembre de 2021 y entre febrero y marzo de 2022, se realizaron 23 entrevistas semiestructuradas y observaciones en una colonia de una comunidad habitada por migrantes asentados que está en proceso de urbanización. Resultados: la práctica del autoconsumo posibilita tener alimentos frescos y apropiados en términos culturales. Además, resignifica la identidad de los pueblos originarios y campesinos asentados en comunidades agroindustriales. Valor: la aportación consiste en visibilizar la práctica emancipadora del autoconsumo frente al modelo de consumo predominante. Limitaciones: no se incluyeron en el estudio los migrantes que se movilizan entre temporadas y que no tienen terrenos para cultivar. Conclusiones: el autoconsumo es una estrategia de resistencia que fomenta la soberanía alimentaria de la población.
Detection and Classification of Cassava Diseases using Machine Learning
Authors: K Jagadish.
Published: December 2023

Abstract: Cassava (Manihot esculenta) is a crucial food crop sustaining millions of people worldwide. However, the presence of diseases in cassava plants poses a significant threat to agricultural productivity. Traditional methods of disease detection are often labor-intensive, subjective, and prone to human error. To address these challenges, this research focuses on developing an automated system for cassava plant disease detection using machine learning. After the algorithms have been trained on the dataset, the accuracy of the algorithms is compared, the photos are categorised, and preventions for unhealthy plants are proposed. Apart from detection, this aims to support and help the greenhouse farmers in an efficient way. Plant disease identification by visual way is more laborious task and at the same time, less accurate and can be done only in limited areas. Whereas if automatic detection technique is used it will take less efforts, less time and become more accurate.
Proposições gerais de território e os professores surdos
Authors: Gianotto Adriano de Oliveira , Marques Heitor Romero
Published: December 2023

O artigo se organiza como uma discussão teórica sobre a realidade das proposições gerais de território no contexto atual. Focaliza uma teorização sobre a constituição desses trabalhadores. Para essa realização, recupera conceitos sobre Território, Territorização, Lugares, Contribuições de cada abordagem para a nossa análise, mobilidade, para defender a situacional de professores Surdos. Além disso, lança mão dos conceitos de Territorização, para defender a Identidade do Professor Surdo não como modulações, mas em constatação enquanto categoria de professores surdos para a legitimidade pelo trabalho educativo explicitam o papel da constituição desses Indivíduos/Sujeitos por meio dos aparatos de significação e seus impactos nas formas como eles foram/são, historicamente, marginalizados. Por isso esta tese aponta caminhos para uma análise de contextos de ação de professores surdos e das formas como suas práticas poderão ser interpretadas.
KARET ALAM HIDROGENASI SEBAGAI MATRIKS POLIMER ALTERNATIF PADA KOMPOSIT ELASTOMER BANTALAN JEMBATAN
Authors: Puspitasari Santi , Chalid Mochammad , Ferdian Falaah Asron , Cifriadi Adi
Published: December 2023

Karet alam hidrogenasi yang terbuat melalui modifikasi kimiawi lateks karet alam secara transfer hidrogenasi katalitik berpotensi digunakan sebagai matriks polimer alternatif pada karet bantalan jembatan. Penelitian ini dilakukan untuk mengkaji peluang pemanfaatan karet alam hidrogenasi pada pembuatan karet bantalan jembatan. Karet alam hidrogenasi yang digunakan pada penelitian ini disintesis pada variasi konsentrasi hidrasin hidrat (40 dan 42,5 bsk) terhadap hidrogen peroksida (30 dan 35 bsk) suhu 40oC dan 50oC. Eksperimen diawali dengan persiapan kompon karet menggunakan mesin giling terbuka dilanjutkan dengan pembuatan vulkanisat karet pada mesin cetak hidraulik. Vulkanisat karet dikarakterisasi sifat fisik dan mekanik mengikuti parameter yang tercantum dalam SNI 3967:2013. Karet SIR 20 digunakan sebagai pembanding. Hasil pengujian menunjukkan bahwa karet alam hidrogenasi yang diolah dari 40 bsk hidrasin hidrat dan 35 bsk hidrogen peroksida pada suhu 40oC ditetapkan sebagai matriks polimer alternatif yang paling menjanjikan untuk produk karet bantalan jembatan. Vulkanisat karet bantalan jembatan dari karet alam hidrogenasi tersebut memiliki sifat fisik dan mekanik yang sesuai dengan persyaratan SNI 3967:2013 dan persentasi rentensi yang lebih tinggi daripada vulkanisat karet bantalan jembatan dari SIR 20.
The Min-Entropy of Classical-Quantum Combs for Measurement-Based Applications
Authors: Smith Isaac D. , Krumm Marius , Fiderer Lukas J. , Nautrup Hendrik Poulsen , Briegel Hans J.
Published: December 2023

Learning a hidden property of a quantum system typically requires a series of interactions. In this work, we formalise such multi-round learning processes using a generalisation of classical-quantum states, called classical-quantum combs. Here, "classical" refers to a random variable encoding the hidden property to be learnt, and "quantum" refers to the quantum comb describing the behaviour of the system. The optimal strategy for learning the hidden property can be quantified by applying the comb min-entropy (Chiribella and Ebler, NJP, 2016) to classical-quantum combs. To demonstrate the power of this approach, we focus attention on an array of problems derived from measurement-based quantum computation (MBQC) and related applications. Specifically, we describe a known blind quantum computation (BQC) protocol using the combs formalism and thereby leverage the min-entropy to provide a proof of single-shot security for multiple rounds of the protocol, extending the existing result in the literature. Furthermore, we consider a range of operationally motivated examples related to the verification of a partially unknown MBQC device. These examples involve learning the features of the device necessary for its correct use, including learning its internal reference frame for measurement calibration. We also introduce a novel connection between MBQC and quantum causal models that arises in this context.
Impērijas trauslā varenība: Karš Ukrainā no postkoloniālisma perspektīvas
Authors: Mencis Roberts
Published: December 2023

Koloniālisma izpausme pasaules vēsturē un šī fenomena būtība nav pilnvērtīgi izprotama, ja netiek ņemts vērā Krievijas vēsturiskais un pašlaik īstenotais koloniālisms pret Ukrainu.
Lietuviešu valstybė ‘valsts’ – Simona Daukanta aizguvums no latviešu valodas
Authors: Subačus Giedŗus , Vanags Pēteris
Published: December 2023

Lietuviešu valodā pārņemt vārdu “valstybė” varēja pamudināt darbs Rīgas gubernatūrā.
IV Fórum de Educação Inclusiva
Authors: Do IFRJ campus Nilópolis NAPNE
Published: December 2023

Resumos do IV Fórum de Educação Inclusiva do NAPNE, realizado no IFRJ campus Nilópolis, no período de 10 a 11 de outubro de 2023.
Enciclopédias da barbárie
Authors: Correa da Silva de Araujo André , Silveira de Abreu Luis Felipe
Published: December 2023

O presente artigo apresenta e discute o conceito de “escritas de comunalidade”, proposto pela escritora mexicana Cristina Rivera Garza. Pensada como forma poética de responder às relações intrínsecas entre escrita e barbárie, a comunalidade discute estratégias pelas quais o discurso pode desconstruir sua própria condição de ferramenta da violência no âmbito discursivo do pós-ditaduras latino-americanas. De modo a articular o aspecto heurístico de tal proposta, propomos uma leitura das formas da comunalidade no romance La literatura nazi en America, de Roberto Bolaño. Concebido como uma enciclopédia de escritores colaboradores do nazifascismo, o livro é discutido aqui a partir de uma leitura dos dois níveis semióticos de sua comunalidade: seu aspecto de necroescritura, como denúncia da violência política, e seu caráter de escrita de desapropriação, que movimenta dispositivos líricos para desarticular aquela violência. A proposta objetiva demonstrar através de estratégias de produção de sentido, como a necroescritura e a desapropriação podem constituir um discurso de comunalidade, na sua relação com uma comunicação da violência.
Elita na mikropodručju: Vinkovci 1939.-1945.
Authors: Horvat Sandra
Published: December 2023

Temeljem tipologije elita Michaela Manna u radu su opisani kontinuiteti i promjene u kretanju vinkovačke elite tijekom Banovine Hrvatske i Nezavisne Države Hrvatske. Na temelju arhivskih izvora i lokalnog tiska rekonstruirani su životi i idejna stremljenja pripadnika ideološke i političke elite u promatranom razdoblju. Rad možemo okarakterizirati kao svojevrsnu studiju slučaja ili lakmus papir za izučavanje ovih promjena u nekom drugom vremenu ili na drugom području. Polazeći od pretpostavke da se promjene na makrorazini na neki način odražavaju i na mikro područje, ispitano je u kojoj je mjeri došlo do promjene vladajuće elite grada. Glavna teza rada je i potvrđena - promjene su se dogodile tijekom oba režima, a primjetne su razlike u intenzitetu promjena. Gradonačelnici Vinkovaca za vrijeme Banovine Hrvatske bili su ljudi bliski vladajućoj Hrvatskoj seljačkoj stranci, dok je nakon uspostave Nezavisne Države Hrvatske po uputama odozgo postavljen novi gradonačelnik. Došlo je i do promjena u ideološkoj eliti grada – očitovanih kroz tisak i obrazovni sustav. Primjerice, isti tjednik Hrvatski Branik sukobljava se s neistomišljenicima tijekom oba režima. Za vrijeme Banovine Hrvatske uredništvo se ne ustručava kritizirati neke bivše dužnosnike s kojima ne dijeli ideološka poimanja, dok se za vrijeme NDH novo uredništvo još upečatljivije obračunava s političkim protivnicima.
Strengthening a resilient protected area workforce to advance the 30x30 goal: the case of Madagascar
Authors: Rakotobe Domoina J. , Dabelko Geoffrey D. , Stevens Nancy J.
Published: December 2023

Protected areas depend on a reliable and strong workforce to achieve biodiversity conservation goals. The Kunming Montreal Global Biodiversity Framework adopted a target to protect at least 30 per cent of the planet’s land and seas by 2030, also known as 30x30. To reach and maintain this ambitious goal, an expanded conservation workforce is indispensable. Despite this, most protected areas are currently critically understaffed. This study examines staffing in shared governance protected areas in Madagascar - a biodiversity hotspot that has significantly expanded its protected area network since 2015. We explore factors that attract and retain protected area workers in order to suggest recommendations for workforce development. We employ a qualitative approach utilising face-to-face interviews and a survey of protected area staff and local  communities in Madagascar. We obtained data from 62 individuals across 10 protected  areas, under IUCN management categories II, V and VI. Findings indicate that understaffing is a dynamic rather than a static phenomenon. A key motivation for working in the protected area sector is place attachment. Non-monetary work practices including place-based empowerment of community groups and gender-inclusive approaches can improve organisational culture to meet growing human resource needs in protected areas. By charting a new path for workforce development, protected areas may be able to address long standing human resources issues and contribute to community empowerment and sustainable livelihood.