bluuebunny/crossref_metadata_2025 huggingface dataset:
Issues of Strategic Legal Regulation of the Implementation of Digital Technologies in Transport
Authors: Voronin V. N.
Published: October 2021

Despite the awareness of the importance of digital transformation of highways as the basis for life safety, social and economic development of the country, the issues of technical, legal and financial regulation of the digitalization of the transport complex at the federal and regional levels, a detailed assessment of the impact of digital technologies in transport on social and economic processes in modern Russian society. In the Russian doctrine in recent years, research has been carried out in general on the formation and development of the digital economy in Russia, in which intelligent transport systems are mentioned pointwise and only in general terms without their comprehensive analysis. Based on the assessment of the current state and trends in the development of info-communication transport infrastructure in Russia, foreign experience, potential problems of the implementation of digital technologies in transport in the socioeconomic and legal dimension were identified, specific proposals were formulated on the legal and financial regulation of issues and minimization of the risks of liability for harm in conditions development of information transport systems. The role of the programs “Digital Economy of the Russian Federation” and “Safe and High-Quality Roads” in the development of intelligent transport systems has been analyzed, and as a result, promising areas for the use of unmanned vehicles to improve the quality of life of people, develop entrepreneurship, high-tech industries, and increase the investment attractiveness of Russia have been identified. and strengthening its position in the international arena. The study used the following methodological principles: objectivity; determinism; historicism; integrity; consistency; structure; functionality; hierarchy; pluralism of explanation and understanding of law; comparative studies. The study uses private methods: legal analytics, legislative techniques, legal comparative studies, expert assessments. As the main results of the study, the features of the legal regulation of new and promising relations arising in the digital economy have been identified. This is a strategic legal planning and legal experiment. Taking into account this conclusion, a system of prerequisites for the development of intelligent transport systems was formulated based on the analysis of national programs. The system of prerequisites includes three levels: technological prerequisites, infrastructural and regulatory.
Simulated Legal Phenomena in the System of Principles of the Administrative Process
Authors: Kirillov D. A.
Published: October 2021

With the inclusion of the category “simulation” in the Code of the Russian Federation on Administrative Offences an interest arose in studying “simulation” in the system of principles of the administrative process. The purpose of the study is to formulate general recommendations for neutralizing the negative consequences of manifestations of feign in the system of principles of the administrative process. The methodological basis of the research is materialistic dialectics and elements of conceptual analysis. The methods of analogy and generalization allow us to justify the use of the construction of “simulated legal phenomenon” for the study of the principles of the administrative process. The survey revealed obstacles to the implementation of certain aspects of the presumption of innocence. The comparative legal analysis allows us to establish the comparability of the volumes of state repression in the measures of administrative and criminal responsibility, a clearly negative assessment of simulation in administrative law compared to its neutral assessment in civil law, to identify a number of obstacles to the functioning of the principles of the administrative process. Other standard research methods are also used. The expediency of analyzing the simulation of the system of principles of the administrative process is justified; a simplified model of the system of principles of the administrative process is used for the analysis; from the standpoint of assessing legal simulation, the analysis of the principle of legality, the principle of procedural equality, the principle of guilt, the principle of presumption of innocence, as well as the principle of respect for the honor and dignity of the individual was carried out. In order to reduce the level of obvious simulation in the system of principles of the administrative process, in particular, it is recommended: in the doctrine of the administrative process to consider the principle of legality not as a reality, but as a goal; in the laws, replace the term “legality” with the term “lawfulness”; in the laws, the wording “the principle of equality before the law” and the like should be replaced with “the principle of equality of rights”; part 1 of Article 1.5 of the Code of the Russian Federation on Administrative Offences should be amended as follows: “a person is subject to administrative responsibility only for those socially harmful actions (acts of inaction) in respect of which his guilt is established”; part 3 of Article 1.5 of the Code of the Russian Federation on Administrative Offences after the words: “...is not obliged to prove his innocence” should be supplemented with the words “but has the right to disagree with all or part of the arguments confirming his guilt, or to refute them”. It is also recommended to amend the legislation in order to unify the approach to the differentiation of administrative offenses and crimes.
Categories “Process” and “Procedures” in the Works of the Classics of Russian Administrative Law: Concept, Relevance and Modernity of the Model
Authors: Kobzar-Frolova M. N.
Published: October 2021

Research topics related to concepts such as “process”, “procedures”, “administrative process” remain the most controversial, and, therefore, relevant. Unfortunately, not many scientists are ready to take part in the creation of a modern theory of the administrative process, the development of unified approaches to its terminology, the formation of a unified Russian model of the administrative process. At the same time, knowledge of the works of recognized classics of Russian procedural law is very important and timely. This article attempts to analyze individual works of the classics of Russian administrative procedural law, who stood at the origins of its creation, to compare their position and draw their own conclusions. The excerpts are given and the positions on the subject and essence of the concepts o process, procedure, stages of such scientists as B. M. Lazarev, V. D. Sorokin, N. G. Salishcheva and some others are demonstrated. The purpose of the work was to prove that the ideas of the scientists who stood at the origins of the Russian administrative procedural law are not only alive, they are relevant and should be relied on in order to: 1) develop unified approaches to the terminology of the administrative process, 2) create a unified modern model of the administrative process. The tasks correspond to the purpose of the study and are aimed at understanding the works of recognized classics of Russian procedural law, popularizing their works, ideas, developments, etc. and highlight the signs of the concepts under study. The applied methods made it possible to individualize the essence of the approaches of the classics of Russian administrative procedural law to the concepts of “process”, “procedure”, “administrative process”, develop their own position, give an author's definition and draw other conclusions corresponding to the study.
Administrative-Procedural Form and Stages as Elements of the Characteristics of the Administrative Process
Authors: Spiridonov P. E.
Published: October 2021

The subject of research in this paper is the administrative-procedural form and stages of the administrative process. The purpose of the study is to analyze the essential characteristics of the administrative-procedural form and stages. It is stated that the evolution of the administrative process and administrative-procedural legal relations entailed changes in the administrative-procedural form, which were influenced by changes in the political system and the system of public administration in the Russian Federation. It is concluded that the improvement of the administrative process and its form ensures compliance with both the interests of the state and society, as well as the rights and legitimate interests of citizens. Attention is drawn to the fact that one of the characteristic features of administrative-procedural legal relations that distinguish it from other types of procedural legal relations – arbitration, civil, criminal, constitutional, is the administrative-procedural form, which is characterized by out-of-court, pre-trial and judicial procedures of proceedings in an administrative case, due to the specifics and features of its subject. The author notes that the administrative-procedural form is an external expression of administrative-procedural activity, and the stages are its internal content. At the same time, the stages of the administrative process are separate, but interrelated stages consisting of administrative procedural actions united by common tasks and intermediate and final administrative procedural decisions, procedural deadlines. Attention is drawn to a certain specificity of the stages of the administrative process, which consists in the fact that they cannot be clearly divided into judicial and pre-trial stages, as it is in the criminal process. The system of stages of the administrative process should be the same for all types of administrative proceedings, since this follows from the principle of self-similarity, when the particular comes from the general and corresponds to it. To determine the place of administrative judicial procedure in the administrative process, it is necessary to understand that the court, as a subject of administrative procedural legal relations, can enter into the process at different stages, and it is not the only subject of administrative procedural relations that makes legally significant procedural decisions. The methodological basis of the article is dialectical, formal-logical methods, formal-legal method and method of interpretation of law.
Creencias, saberes y prácticas populares de salud en mujeres en situación de pobreza en el Gran Río Cuarto (Córdoba-Argentina)
Authors: Juárez María Paula
Published: October 2021

Objective: The article reflects on knowledge, beliefs and practices in health, illness and care of women in poverty in the south of the province of Córdoba, Argentina. It is positioned in the conceptual proposal of the sanitary psychologist Enrique Saforcada on “the fundamental contexts of public health”, focusing on the “context of the lay health concepts and practices of society”.
Materials and methods: From a qualitative methodology, stories of 11 women living in three communities living in poverty are recovered. The sample was made up of voluntary informants according to their willingness to participate in the study. Semi-structured interviews were conducted based on the axes of knowledge, practices and beliefs in health. The qualitative analysis was developed, in a synchronic key, building a theoretical explanatory scheme supported by Grounded Theory procedures and, in a diachronic key, interpreting the data from the narrative biographical perspective.
Results: The categories emerged: construction and dynamization of popular knowledge in health in the lives of women; uses and customs in healing / healing practices; healing / healing oriented beliefs.
Conclusions: The conceptions, practices and beliefs in health-disease-care make up popular knowledge emerging from intersubjective and dialogical processes where the protagonists are adult and young women who, as teachers and learners, dynamize a particular type of social interaction based on meanings of health , disease, care and attention linked to their life experiences, forming an epistemic body that nurtures actions for the promotion and protection of health, as well as care for disease and restoration of health. It reflects on: a) the importance of knowledge in health in the face of scenarios of expropriation / appropriation of health; b) the paradigms underlying these lay conceptions and practices.
Validación psicométrica del índice de Barthel en adultos mayores mexicanos
Authors: Duarte Ayala Rocio Elizabeth , Velasco Rojano Ángel Eduardo
Published: October 2021

Abstract
Objective: Geriatric population is increasing worldwide and knowing their healthstatus is necessary to be able to plan public policies that improve their quality of life, functional independence through the ability to do basic daily activities is a good indicator to know the health and need of medical care. One of the most used scales for this is the Barthel Index, so the purpose of this work was to validate this scale psychometrically, to identify if its structure is the most appropriate through confirmatory factorial analysis.
Materials and methods: It was worked with two groups of participants, 200 senior citizens of Mexico City for validation and 276 senior inhabitants of Mexico City for confirmatory factorial analysis.
Results: A structure with ten reagents, adequate reliability and correct adjustment was found. Cronbach's Alpha coefficient [Alpha = 0.96, CI95% (0.95-0.97)], Revelle's Beta (Beta = 0.91), McDonald's omega (Omega = 0.90) and the highest lower limit of Ten Berge and Socan were calculated. (glb = 0.96).
Conclusions: The Barthel index in self-report has psychometric properties that make it a reliable and valid measure for the purpose of evaluating functional independence in the geriatric population of Mexico City.
Transformación integral del sistema de salud de la República Democrática de Timor Leste (2013-2016)
Authors: Montero Díaz Rolando , Santana López Sandra , Carnota Lauzán Orlando , Arocha Mariño Carmen , Avalos García María Isabel
Published: October 2021

Objective. Establish a comprehensive transformation of the health system of the Democratic Republic of Timor Leste (2013-2016). Materials and methods. A research / action type study was carried out from the managerial perspective, with an exhaustive use of methods, techniques and tools associated with the qualitative approach and health management in the Democratic Republic of Timor Leste, during the period 2013- 2016. Results. In a first phase, the situational analysis was carried out at the country level. With these elements, the strategic priorities, objectives, indicators and goals were successively defined for each perspective. Finally, the change program was organized, the transformation process was carried out and the results were determined. The National Cancer Program and the National Primary Care Program were designed and kept functioning; Missing medical specialties and care services were introduced; New approaches to human resource management were created and the level of scientific work was raised, among other benefits. Conclusions. There were substantial improvements in the health system and in addition, a potential capacity was created so that these effects continue to grow in quantity and quality.
Keywords: health care reform, situational analysis, balanced scorecard, managerial technologies
Robles, Lola. Identidades confinadas
Authors: Argyriou Konstantinos
Published: October 2021

Este artículo reseña:

Robles, Lola. Identidades confinadas: La construcción de un conflicto entre feminismo, activismo trans y teoría queer. Útero Libros, Castellón, 2021, 232 pp. ISBN: 978-84-949949-6-8
COAGULANT-FLOCCULANT FROM SECONDARY RESOURCES FOR TREATMENT OF INDUSTRIAL AND MUNICIPAL WASTEWATER
Authors: Shablovski Vladimir , Tuchkoskaya Alla , Rukhlya Vladimir , Pap Olga
Published: October 2021

Coagulants and flocculants are used almost at all drinking water supply facilities, wastewater treatment plants of municipal and industrial enterprises in Belarus and Ukraine to intensify and increase the efficiency of the processes of purification, clarification and discoloration of water and wastewater. Mainly as coagulants aluminum and iron salts are used, as flocculants - active silicic acid, starch, cellulose derivatives, polyacryloamide, etc.

Sulfuric acid treatment of alumina-containing raw materials allows, in the course of one process, to obtain a mixture of active substances - salts of aluminum, iron, active SiO2. In this case, there is no need to separate the salt from suspended particles and colloidal silicic acid. The presence of suspended dispersed particles in the active substance, as well as colloidal silicic acid and its salts, enhances and accelerates coagulation. The resulting solution, along with aluminum sulfate, contains silicic acid, which acts as a flocculant in the process of water purification. In addition, the processed products also contain ferrous sulfate, in the presence of which a better coagulation result is achieved.

Industrial tests of the coagulant-flocculant were carried out in order to purify wastewater from oil products. The test results showed that the effectiveness of the coagulant-flocculant in reducing the content of oil products in wastewater is comparable to the currently used aluminum sulfate.

The effectiveness of the developed coagulant-flocculant for the purification of drinking water was evaluated in comparative tests with a coagulant “Polvak-68” in the mode of trial coagulation on a laboratory flocculator. The research results are showed that the value of all parameters characterizing the contamination of the source water are highty decreasing for experimental coagulant-flocculant in compare with regular product.
Transforming the digital leadership to improve public service performance in the COVID-19 outbreak
Authors:   Universitas Airlangga Surabaya, Susilawati Dwi Mardiana , Suryanto  ,   Universitas Airlangga Surabaya, Windijarto  ,   Universitas Airlangga Surabaya
Published: October 2021

The low HDI in Pandalungan is a government-focused development priority, especially in the healthcare sector. The attempts to break the COVID-19 chain must be made to improve the quality of government services in the region. In optimizing the activities, the sub-district leaders play a significant role. There is an appeal to the sub-district leaders to enforce social distance since there is no face-to-face meeting with the appliance assigned. The Camat (a sub-district head) needs to adjust to this situation, so the Camat uses new media to perform his tasks. The COVID-19 pandemic affects several aspects of life, including the style of leadership. Digital leadership has become a model of leadership that is successful during the time of the COVID-19 pandemic. The current study, based on those evaluations, is aimed at assessing the impact of digital leadership on the performance of public services by the sub-district chief Pandalungan. To meet the goal of the study, a qualitative approach is applied. It can be concluded that transformational leadership is oriented towards the organization’s vision and goals, which are outlined in action.
Buku Ajar Manajemen SDM
Authors: Febriansah Rizky Eka
Published: October 2021

Puji syukur kehadirat Allah SWT atas segala anugerah dan rahmat-Nya, sehingga Buku Ajar Manajemen SDM untuk Fakultas Ekonomi dan Bisnis Universitas Muhammadiyah ini dapat terselesaikan dengan baik.Buku Ajar Manajemen SDM ini terdiri dari 14 Bab Materi Perkuliahan, yang merupakan satukesatuan materi yang dipelajari oleh mahasiswa secara menyeluruh dan tak terpisahkan selama satu semester karena merupakan satu kesatuan yang utuh dalam Capaian Kompetensi dari Manajemen SDM di Rencana Pembelajaran Semester . Tujuan diterbitkan buku ajar ini untuk membantu mahasiswa agar dapat menguasai konsep pengelolaan Sumber Daya Manusia dalam ekonomi dan bisnis secara mudah, dan utuh. Di samping itu pula, buku ajar ini dapat digunakan sebagai acuan bagi dosen yang mengampu mata kuliah Manajemen Sumber Daya Manusia. Isi modul ini memuat 5 komponen utama yaitu; Pendahuluan, Penyajian Materi, Rangkuman, Latihan dan Daftar Pustaka. Buku Ajar Manajemen SDM Ekonomi dan Bisnis ini diterbitkan oleh Universitas Muhammadiyah Sidoarjo (UMSIDA) Press untuk kalangan sendiri. Buku Ajar ini merupakan buku terbitan edisi pertama yang tentunya masih butuh disempurnakan. Oleh karena itu, saran dan masukan oleh para pengguna sangat kami harapkan untuk kesempurnaan isi buku ajar ini di masa yang akan datang.
Fold-Related Fracture Distribution in Neogene, Triassic, and Jurassic Sandstone Outcrops, Northern Margin of the Tarim Basin, China: Guides to Deformation in Ultradeep Tight Sandstone Reservoirs
Authors: Wang Junpeng , Zeng Lianbo , Yang Xianzhang , Liu Chun , Wang Ke , Zhang Ronghu , Chen Xiguang , Qu Yuanji , Laubach Stephen E. , Wang Qiqi
Published: October 2021

Ultradeep (6-8 km depth) low-porosity sandstone oil and gas reservoirs, in the Kuqa thrust belt of Tarim Basin, are an important natural gas supply source of China. Both opening and shear-mode fractures are extremely necessary reservoir elements for gas production in these rocks but are challenging to characterize with sparse core and well log observations. Here, we use outcrops of some of the same units from four exposed folds to describe fracture types and patterns. These four folds have a range of shapes that are representative of folds at depth. At the Dongq, Kuqa, Misib, and Tuger anticlines, we analyzed fracture type, cross-cutting and abutting relations, density, spatial arrangement, kinematic aperture, orientation, and mineral fill. One-dimensional inventories, field sketches, photographs, and LiDAR imagery documented fracture patterns. Most dips of all fractures shown everywhere on the fold are greater than 60 degrees (over 50%). Fracture kinematic apertures are 3 mm to ~6 mm, and fracture density is 0.5 traces/m to ~1.5 traces/m. All fractures are divided into shear mode (or small faults) and opening mode. Shear-mode fractures, with high dips that strike N-S, mutually crosswise arranged with intersection angles of 30-60 degrees, are found extensively on the flanks of these folds. In contrast, most opening-mode fractures strike E-W, are arranged parallel to each other, and are localized in fold hinges. Besides, exposed folds (reservoir analogues, figure 1) in a proximal (hinterland, Tuger and Misib) position have fracture abundance distributions and aperture size patterns compatible with fold-related fracture development whereas distal (basinward, Kuqa and Dongq) folds lack this correlation, but patterns in distal folds might be explained by overprinted effects of lithological heterogeneity on fracture abundance or the effects of nearby faults. The positive correlation between fold-related strain and fracture spatial distribution in the northern (proximal) folds permitted inference of fracture patterns in deep wells.
Evaluation of Two Different Strategies for Schistosomiasis Screening in High-Risk Groups in a Non-Endemic Setting. A Retrospective Cohort Study.
Authors: Roade Luisa , Sulleiro Elena , Bocanegra Cristina , Salvador Fernando , Treviño Begoña , Zarzuela Francesc , Goterris Lidia , Serre-Delcor Nuria , Oliveira-Souto Inés , Aznar Maria Luisa , Pou Diana , Sánchez-Montalvá Adrián , Bosch-Nicolau Pau , Espinosa Juan , Molina Israel
Published: October 2021

Background: to evaluate the real-life performance of direct microscopy techniques and ELISA serology for schistosomiasis screening in a high-risk population in a non-endemic setting. Methods: a retrospective cohort study was conducted in two out-patient Tropical Medicine units in Barcelona (Spain) from 2014 to 2017. Asymptomatic adults arriving from the Sub-Saharan region were included. Schistosomiasis screening was conducted according to clinical practice following a different strategy in each setting: A) feces and urine direct examination plus S. mansoni serology if non-explained eosinophilia was present, B) S.mansoni serology plus uroparasitological examination at second-step in case of a positive serology. Demographic, clinical and laboratory features were collected. Schistosomiasis cases, clinical management and 24 months follow-up were recorded for each group.Results: Four-hundred forty individuals were included: 399 in group A, 41 in group B. The majority of the cohort were male (250, 56.4%), mainly from West African countries. No differences in sex distribution (p=0.57), age (p=0.6) and baseline eosinophilia (p=0.17) were found between both groups. Fifty schistosomiasis cases were detected (11.5% group A vs 4 % group B, p=0.733). When both microscopic and serological techniques were performed, discordant results were recorded in 18.2% (16/88)). Eosinophilia was present in 50% cases. Schistosomiasis cases were younger (p<0.001) and presented more frequently eosinophilia and elevated IgE (p<0.001). Pathological ultrasound was described in 33.3% of examinations performed (4 out of 12). Conclusions: Similar results were achieved by serology and microscopy techniques -based strategies. Serology might be prioritized for schistosomiasis screening of asymptomatic adults from endemic areas, regardless peripheric eosinophil count or IgE levels.
LncRNA Pnky Positively Regulates Neural Stem Cell Migration via Modulating mRNA Splicing and Export of Target Genes
Authors: Du Jiannan , Li Yuan , Su Yuting , Zhi Wenqian , Zhang Jiale , Zhang Cheng , Wang Juan , Deng Wensheng , Zhao Shasha
Published: October 2021

Directed migration of neural stem cells (NSCs) is critical for embryonic neurogenesis and the healing of neurological injuries. LncRNA Pnky was reported to regulate neuronal differentiation of NSCs. However, its regulatory effect on NSC migration has never been explored. Herein, we identified that Pnky was also a key regulator of NSC migration, as underscored by the fact that Pnky silencing restrained the migration of both NSC lines C17.2 and NE4C, whereas Pnky over-expression promoted their migration. Meanwhile, Pnky regulated the expression of a core set of critical regulators that directing NSC migration, such as MMP2, MMP9, AKT and p38MAPK, etc. Through preliminary bioinformatics, we surprisingly noticed that splicing factors U2AF1 and U2AF1L4, as well as mRNA export adaptors SARNP, Aly/Ref and THOC7, were predicted to strongly interact with Pnky. Mechanically, Pnky could co-localize and directly bind to U2AF1, SARNP, Aly/Ref and THOC7, indicating the involvement of Pnky in modulating mRNA splicing and export processes. Collectively, our data delineated that, through interacting with U2AF1, SARNP, Aly/Ref and THOC7, Pnky coupled and modulated the mRNA splicing and export of downstream factors, which consequently affected NSC migration. These findings provide a possible theoretical basis of NSC migration for brain development and damage repair.
Environmental Enrichment Protects Offspring of a Rat Model of Preeclampsia from Cognitive Decline
Authors: Lu Huiqing , Gong Lili , Xu Huangfang , Zhou Qiongjie , Zhao Huanqiang , Wu Suwen , Hu Rong , Li Xiaotian
Published: October 2021

Background
Preeclampsia affects 5–8% of all pregnancies and contributes to adverse pregnancy and birth outcomes. In addition to the short-term effects of preeclampsia, preeclampsia can exert long-term adverse effects on offspring. Numerous studies have demonstrated that offspring of preeclamptic women exhibit cognitive deficits from childhood to old age. However, effective ways to improve the cognitive abilities of these offspring remain to be investigated. The aim of this study was to explore whether environmental enrichment in early life could restore the cognitive ability of the offspring of a rat model of preeclampsia and to investigate the cellular and molecular mechanisms by which EE improves cognitive ability.
Methods
L-NAME was used to establish a rat model of preeclampsia. The spatial learning and memory abilities and recognition memory of 56-day-old offspring were evaluated by the Morris water maze and Novel object recognition (NOR) task. Immunofluorescence was performed to evaluate cell proliferation and apoptosis in the DG region of the hippocampus. qRT-PCR was performed to examine the expression levels of neurogenesis-associated genes, pre- and postsynaptic proteins and inflammatory cytokines. An enzyme-linked immune absorbent assay was performed to evaluate the concentration of vascular endothelial growth factor (VEGF) and inflammatory cytokines in the hippocampus.
Results
The administration of L-NAME led to increased systolic blood pressure and urine protein levels in pregnant rats. Offspring in the L-NAME group exhibited impaired spatial learning ability and memory as well as NOR memory. Hippocampal neurogenesis and synaptic plasticity were impaired in offspring from the L-NAME group. Furthermore, cell apoptosis in the hippocampus was increased in the L-NAME group. The hippocampus was skewed to a proinflammatory profile, as shown by increased inflammatory cytokine levels. EE improved the cognitive ability of offspring in the L-NAME group and resulted in increased hippocampal neurogenesis and synaptic protein expression levels and decreased apoptosis and inflammatory cytokine levels.
Conclusions
Environmental enrichment resolves cognitive impairment in the offspring of a rat model of preeclampsia by improving hippocampal neurogenesis and synaptic plasticity and normalizing the apoptosis level and the inflammatory balance.
Effect of Input Servitization On Carbon Emission Reduction: Evidence From China's Manufacturing Industry
Authors: Hao Mingrui , Tang Yiding , Zhu Shujin
Published: October 2021

As a new form of industry that integrates manufacturing and service, manufacturing servitization is not only conducive to high-quality economic development, but also has a positive effect on reducing carbon emissions. Using panel data of 30 provincial sub-sectors in China, this study systematically investigates the effect of manufacturing input servitization on carbon emission reduction. The results showed that input servitization can reduce carbon emissions. Concerning the regional heterogeneity, input servitization plays a relatively more important role in China’s central region. Concerning the industrial heterogeneity, the carbon reduction effect of input servitization in pollution-intensive manufacturing sectors is greater than in non-pollution sectors. Furthermore, the mediating test demonstrates that input servitization reduces carbon emissions by improving technological innovation and optimizing the structure, while technological innovation is more effective in achieving carbon emission reduction. These conclusions show that improving the input servitization level of the manufacturing industry is feasible to coordinating the development of the manufacturing industry and the attaining the goals of China’s carbon emission reduction.
SP70 is a Potential Biomarker to Identify Gastric Fundic Gland Neoplasms
Authors: Luo Rongkui , Huang Wen , Chen Lingli , Liu Yalan , Xu Lei , Zhang Xiaolei , Xu Chen , Hou Yingyong
Published: October 2021

Background Gastric neoplasms with fundic gland differentiation include oxyntic gland adenomas (OGAs) and gastric adenocarcinomas of fundic gland type (GA-FGs). Due to their extremely well differentiation and morphological similarity to normal fundic glands, it is usually challenging to identify these lesions in pathological diagnosis, especially in biopsy specimens. This study aims to explore and verify the potential role of a newly developed monoclonal antibody (McAb) NJ001 (SP70) in differentiating fundic neoplasms from non-neoplastic fundic gland lesions. Methods Twenty-three cases of histological confirmed gastric fundic gland neoplasms were obtained, including 12 cases of OGAs and 11 of GA-FGs. Fifty cases of fundic gland polyps (FGPs) were also obtained in the control group. Key clinicopathological information was collected. SP70 immunostaining was performed, the intensity, as well as the staining pattern was analyzed and compared. The para-tumor normal fundic glands were used as internal control.Results In normal gastric mucosa, SP70 was strongly and diffusely stained on the cytoplasm in fundic glands, but not in foveolar epithelium. Therefore, a zonal distribution of SP70 was observed in normal mucosa. FGPs (50/50, 100%) shared a similar expression pattern with normal fundic glands. In fundic gland neoplasms, a significant down-expression of SP70 was observed in both OGAs and GA-FGs. The positive rate of SP70 in fundic gland neoplasms (6/23, 26.1%) was significantly lower than that in FGPs (100%) (P＜0.0001). There was no difference of SP70 positivity between OGAs (3/12, 25.0%) and GA-FGs (3/11, 27.2%) group (P>0.05).Conclusion Down-expression of SP70 is a specific feature to fundic gland neoplasms including OGAs and GA-FGs. Therefore, SP70 can serve as a potential biomarker in the identification and differential diagnosis of fundic gland neoplasms.
Impact of Relational Continuity of Primary Care in Aged Care: A Systematic Review
Authors: Dyer Suzanne M , Suen Jenni , Williams Helena , Inacio Maria C , Harvey Gillian , Roder David , Wesselingh Steve , Kellie Andrew , Crotty Maria , Caughey Gillian
Published: October 2021

Background: Greater continuity of care is associated with lower patient mortality. The aim of this systematic review was to examine the impact of relational continuity between a primary care practitioner and older people receiving aged care services, in residential or home care settings, on health care resource use and person-centred outcomes.Methods: Systematic review of five databases, four trial registries and three grey literature sources to October 2020. Included studies (a) aimed to increase relational continuity with a primary care professional, (b) focus on people receiving aged care services (c) included a comparator and (d) reported outcomes of health care resource use, quality of life, activities of daily living, mortality, falls or satisfaction. Cochrane Collaboration or Joanna Briggs Institute criteria were used to assess risk of bias and GRADE criteria to guide confidence in evidence and conclusions.Results: Heterogeneity in study cohorts, settings and outcome measurement in the five included studies (one randomised) precluded meta-analysis. No included studies examined relational continuity exclusively with non-physician providers. Higher relational continuity with a primary care physician probably reduces emergency department (ED) presentations (moderate certainty evidence; high versus low continuity hazard ratio (HR) 0.90, 95% confidence interval (CI) 0.89–0.92, n=178,686; incidence rate ratio (IRR) 0.91, 95%CI 0.72–1.15, n=246) and may reduce hospital admissions slightly (low certainty evidence; high versus low continuity HR 0.94; 95%CI 0.92–0.96, n=178,686; IRR 0.91, 95%CI 0.76–1.27, n=246) for older community-dwelling aged care recipients. The benefit of providing on-site primary care in residential settings is uncertain (low certainty evidence, 2 studies, n=2,468 plus 15 care homes); whilst there are probably lower hospitalisations and may be fewer ED presentations, there may also be an increase in reported mortality and falls. The benefit of general practitioners’ visits during hospital admission is uncertain (very low certainty evidence, 1 study, n=335).Conclusion: Greater relational continuity with a primary care physician probably reduces ED presentations and may reduce hospitalisations slightly for community-dwelling aged care recipients, thus policy initiatives that increase continuity may have cost offsets. Further studies of approaches to increase relational continuity of primary care in aged care settings are needed.Registration: PROSPERO CRD42021215698
Two-fifths of women are not autonomous in maternal health service utilization: A community-based cross-sectional study
Authors: Kassahun Asmamaw , Zewdie Asrat
Published: October 2021

Background: Autonomy of women in health care decision-making is tremendously crucial for improved maternal health outcomes and women’s empowerment. Women with greater freedom of movement are more likely to receive maternal health services. However, little has been investigated about women’s autonomy in maternal health care decision-making and contributing factors in Ethiopia. The aim of this study was to assess decision-making autonomy on maternal health care services utilization and associated factors among women.Methods: A community-based cross-sectional study was conducted in Mettu rural Woreda, Ilu Aba Bor zone, southwest Ethiopia from June 19 to August 20, 2021. Data was collected using a pretested interviewer-administered questionnaire from 541 randomly selected women. The collected data was entered into Epi-Data version 3.1 and exported to SPSS version 22 for analysis. Bivariate and multivariate logistic regression was used to identify factors associated with women's decision-making autonomy on maternal health service utilization. The significance of association was declared by using the odds ratio with a 95% confidence interval and a p-value less than 0.05 in the multivariable model.Results: Out of 522 women included in the analysis, 322 (60.5%) (95% CI: 56.2%-64.7%) were found to be autonomous on maternal health service utilization. Age category from 30-39 years, AOR=4.27 (95%CI: 1.59-11.43), attending primary education and above, AOR=3.87 (95%CI: 2.15-6.99), greater than five family size, AOR=0.25 (95%CI: 0.15-0.41), and distance from the health facility, AOR=5.33 (95%CI: 2.50-11.33) were significantly associated with women's decision-making autonomy on maternal health care services utilization.Conclusion: Even though every woman has the right to participate in her own health care decision-making, around two fifths of them have no role in making health care decisions about their own health. Socio-demographic factors like age and education were found to influence women’s autonomy. Special attention has to be given to women living in rural areas in order to reduce their dependency through education.
Analysis of the Efficacy and Renal Prognosis of a Reduced-Dose Immunosuppressive Regimen of Mild to Moderate ANCA-Associated Renal Vasculitis
Authors: Li Ziyang , Bao Jiwen , Yao Huanzhen , Zhang Minfang , Gu Leyi , Ni Zhaohui , Wang Ling
Published: October 2021

ObjectivesSecondary infection caused by high-dose immunosuppressive therapy is one of the most common causes of death in patients with ANCA-associated vasculitis. This study aimed to explore whether reduced-dose immunosuppressive therapy can achieve the same efficacy while reducing secondary infection in mild to moderate ANCA-associated renal vasculitis and to determine whether early secondary infections will affect the deterioration of renal function.MethodsThe efficacy and safety of the reduced-dose regimen and standard regimen were compared using the chi-square test. The renal survival rates were estimated using the Kaplan–Meier method and compared using the log rank test. Potential variates were examined using multivariate Cox proportional hazard models to determine the risk predictors of end-stage renal disease.ResultsA total of 35 patients in the standard-dose glucocorticoid group and 23 in the reduced-dose glucocorticoid group were included. The average age of the included patients was 62.45±12.70 years, and the baseline serum creatinine was 251.35 [155.53, 445] μmol/L. Nine patients (15.52%) developed ESRD within 24 months (7 standard vs. 2 reduced, P=0.035). Multivariate Cox regression model analysis proved that baseline serum creatinine (HR: 0.007, 95% CI: 2.48-39.48, P=0.014), secondary infection rate within the first 3 months (HR: 2.28, 95% CI: 2.14 45.27, P=0.003), and persistent hematuria for more than 6 months (HR: 1.723, 95% CI: 0.043-0.738, P=0.017) were risk predictors of end-stage renal disease in ANCA-associated renal vasculitis.ConclusionThe regimen of initial reduced-dose immunosuppressive therapy can significantly reduce the secondary infection rate in mild to moderate ANCA-associated renal vasculitis patients, and the efficacy is not inferior to the standard regimen. Patients who had secondary infection within the first 3 months were at higher risk of developing ESRD.
RETRACTED: Urban Poverty and Child Malnutrition in India: A Geographical Analysis
Authors: Das UJJWAL , Mohanty Sanjay K.
Published: October 2021

The authors have requested that this preprint be removed from Research Square.
Quantitative Susceptibility Mapping of Brain Iron Deposition in Patients with Recurrent Depression
Authors: Duan Xinxiu , Xie Yuhang , Zhu Xiufang , Chen Lei , Li Feng , Feng Guoquan , Li Lei
Published: October 2021

Background
Recurrence is the most significant feature of depression and the relationship between iron and depression is still lack of direct evidence in vivo.
Purpose
To explore the relationships between the brain iron and the multiple recurrent depression using quantitative susceptibility mapping (QSM).
Methods
Twenty-one patients with depression (before and after treatment) and twenty control subjects were included. Gradient-recalled echo (GRE), T1 and T2 images were acquired using a 3.0T MRI system. After QSM were reconstructed and standardized, a whole-brain and the regions of interest (ROIs) were respectively analyzed using the permutation test and voxel-wise methods. In addition, regional QSM analysis and Pearson correlation test on the susceptibility of ROIs with depression-related conditions were performed.
Results
Significant increases in susceptibility were found in multiple recurrent depression patients, which involved several brain regions. Interestingly, no susceptibility changes after treatment compared to pre-treatment (all P>0.05) and no significant correlation between susceptibility and Hamilton Depression Rating Scale (HRDS) were found. Besides, it was close to significance that those with a higher relapse frequency or a longer mean duration of single episode had a higher susceptibility in the putamen, thalamus, and hippocampus. Further studies showed susceptibility across the putamen (ρ2 = 0.27, P<0.001), thalamus (ρ2 = 0.21, P<0.001), and hippocampus (ρ2 = 0.19, P<0.001) were strongly correlated with total course of disease onset.
Conclusions
Brain iron deposition is related to the total course of disease onset, but not the severity of depression, which suggest that brain iron deposition may be a sign of brain damage in multiple recurrent depression.
Oral Probiotic Expressing Human Ethanol Dehydrogenase Attenuates Damage Caused by Acute Alcohol Consumption
Authors: Jiang Xiaoxiao , Yan Chunlong , Yuan Shouli , Zhang Hanlin , Ye Rongcai , Zhou Huiqiao , Chen Li , Jiang Rui , Zheng Kexin , Huang Yuanyuan , Jin Wanzhu , Sun Gang , Dong Meng , Liu Xiaomeng
Published: October 2021

Alcohol is an essential drug in human life with multiple medical functions, but excessive alcohol intake, even a single episode of binge-drinking, can cause serious damage. Reducing alcohol consumption or absorption is a direct way to alleviate this harm. Alcohol is decomposed successively by alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) in the liver. Many anti-hangover drugs are intended to increase the activity of these two enzymes, which are weakened in many people owing to gene polymorphisms. Here, we produced a high-activity human ADH1B (hADHIB)-expressing probiotic that secreted the hADH1B enzyme to decompose alcohol in the intestinal tract after oral administration. Our results showed that the oral hADHIB-expressing probiotic reduced the absorption of alcohol, prolonged alcohol tolerance time, and shortened the recovery time after drinking. Alongside, fat accumulation in liver and basal structure disorder of small intestine caused by heavy alcohol intake was improved. Therefore, the engineered probiotic has the potential to be prepared as a mate to wine. This study also demonstrated for the first time that alcohol decomposition can be catalyzed by ectopically expressed hADH1B, providing a practical basis for subsequent development of super-biological antidotes that effectively deliver multiple enzymes.
Root Loci Analysis of a Simple Quasi-Polynomial And Its Use For Relay-Based Parameter Identification of a Delayed Infinite-Dimensional Heat-Exchanger Process
Authors: Pekař Libor , Song Mengjie , Padhee Subhransu , Dostálek Petr , Zezulka František
Published: October 2021

The focus of this contribution is twofold. The first part aims at the rigorous and complete analysis of pole loci of a simple delayed model, the characteristic function of which is represented by a quasi-polynomial with a non-delay and a delay parameter. The derived spectrum constitutes an infinite set, making it a suitable and simple-enough representative of even high-order process dynamics. The second part intends to apply the simple infinite-dimensional model for relay-based parameter identification of a more complex model of a heating-cooling process with heat exchangers. Processes of this type and construction are widely used in industry. The identification procedure has two substantial steps. The first one adopts the simple model with a low computational effort using the saturated relay that provides a more accurate estimation than the standard on/off test. Then, this result is transformed to the estimation of the initial characteristic equation parameters of the complex infinite-dimensional heat-exchanger model using the exact dominant-pole-loci assignment. The benefit of this technique is that multiple model parameters can be estimated under a single relay test. The second step attempts to estimate the remaining model parameters by various numerical optimization techniques and also to enhance all model parameters via the Autotune Variation Plus relay experiment for comparison. Although the obtained unordinary time and frequency domain responses may yield satisfactory results for control tasks, the identified model parameters may not reflect the actual values of process physical quantities.
An All-in-One Bio-inspired Neural Network
Authors: Radhakrishnan Shiva Subbulakshmi , Dodda Akhil , Das Saptarshi
Published: October 2021

In spite of recent advancements in artificial neural networks (ANNs), the energy efficiency, multifunctionality, adaptability, and integrated nature of the biological neural networks largely remain unimitated in hardware neuromorphic computing systems. Here we exploit optoelectronic, computing, and programmable memory devices based on emerging two-dimensional (2D) layered materials such as MoS2 to demonstrate a monolithically integrated, multi-pixel, and “all-in-one” bio-inspired neural network (BNN) capable of sensing, encoding, learning, forgetting, and inferring at miniscule energy expenditure. We also demonstrate learning adaptability and stimulate learning challenges under specific synaptic conditions to mimic biological learning. Our findings highlight the potential of in-memory computing and sensing based on emerging 2D materials, devices, and integrated circuits not only to overcome the bottleneck of von Neumann computing in conventional CMOS designs but also aid in eliminating peripheral components necessary for competing technologies such as memristors.