bluuebunny/crossref_metadata_2025 huggingface dataset:
Abnormalities in Dynamic Brain Activity Caused by Mild Traumatic Brain Injury Are Partially Rescued by the Cannabinoid Type-2 Receptor Inverse Agonist SMM-189
Authors: Liu Yu , McAfee Samuel S. , Guley Natalie M. , Del Mar Nobel , Bu Wei , Heldt Scott A. , Honig Marcia G. , Moore Bob M. , Reiner Anton , Heck Detlef H.
Published: July 2017

Mild traumatic brain injury (mTBI) can cause severe long-term cognitive and emotional deficits, including impaired memory, depression, and persevering fear, but the neuropathological basis of these deficits is uncertain. As medial prefrontal cortex (mPFC) and hippocampus play important roles in memory and emotion, we used multi-site, multi-electrode recordings of oscillatory neuronal activity in local field potentials (LFPs) in awake, head-fixed mice to determine if the functioning of these regions was abnormal after mTBI, using a closed-skull focal cranial blast model. We evaluated mPFC, hippocampus CA1, and primary somatosensory/visual cortical areas (S1/V1). Although mTBI did not alter the power of oscillations, it did cause increased coherence of θ (4-10 Hz) and β (10-30 Hz) oscillations within mPFC and S1/V1, reduced CA1 sharp-wave ripple (SWR)-evoked LFP activity in mPFC, downshifted SWR frequencies in CA1, and enhanced θ-γ phase-amplitude coupling (PAC) within mPFC. These abnormalities might be linked to the impaired memory, depression, and persevering fear seen after mTBI. Treatment with the cannabinoid type-2 (CB2) receptor inverse agonist SMM-189 has been shown to mitigate functional deficits and neuronal injury after mTBI in mice. We found that SMM-189 also reversed most of the observed neurophysiological abnormalities. This neurophysiological rescue is likely to stem from the previously reported reduction in neuron loss and/or the preservation of neuronal function and connectivity resulting from SMM-189 treatment, which appears to stem from the biasing of microglia from the proinflammatory M1 state to the prohealing M2 state by SMM-189.
Molecular characteristics of the KCNJ5 mutated aldosterone-producing adenomas
Authors: Murakami Masanori , Yoshimoto Takanobu , Nakabayashi Kazuhiko , Nakano Yujiro , Fukaishi Takahiro , Tsuchiya Kyoichiro , Minami Isao , Bouchi Ryotaro , Okamura Kohji , Fujii Yasuhisa , Hashimoto Koshi , Hata Ken-ichiro , Kihara Kazunori , Ogawa Yoshihiro
Published: July 2017

The pathophysiology of aldosterone-producing adenomas (APAs) has been investigated via genetic approaches and the pathogenic significance of a series of somatic mutations, including KCNJ5, has been uncovered. However, how the mutational status of an APA is associated with its molecular characteristics, including its transcriptome and methylome, has not been fully understood. This study was undertaken to explore the molecular characteristics of APAs, specifically focusing on APAs with KCNJ5 mutations as opposed to those without KCNJ5 mutations, by comparing their transcriptome and methylome status. Cortisol-producing adenomas (CPAs) were used as reference. We conducted transcriptome and methylome analyses of 29 APAs with KCNJ5 mutations, 8 APAs without KCNJ5 mutations and 5 CPAs. Genome-wide gene expression and CpG methylation profiles were obtained from RNA and DNA samples extracted from these 42 adrenal tumors. Cluster analysis of the transcriptome and methylome revealed molecular heterogeneity in APAs depending on their mutational status. DNA hypomethylation and gene expression changes in Wnt signaling and inflammatory response pathways were characteristic of APAs with KCNJ5 mutations. Comparisons between transcriptome data from our APAs and that from normal adrenal cortex obtained from the Gene Expression Omnibus suggested similarities between APAs with KCNJ5 mutations and zona glomerulosa. The present study, which is based on transcriptome and methylome analyses, indicates the molecular heterogeneity of APAs depends on their mutational status. Here, we report the unique characteristics of APAs with KCNJ5 mutations.
Obesity, a serious etiologic factor for male subfertility in modern society
Authors: Liu Yue , Ding Zhide
Published: July 2017

Obesity, defined as excessive accumulation of fat in adipose tissue, is a metabolic disorder resulting from behavioral, environmental and heritable causes. Obesity increases the risks of hypertension, diabetes, cardiovascular disease, sleep apnea, respiratory problems, osteoarthritis and cancer. Meanwhile, the negative impact of obesity on male reproduction is gradually recognized. According to the clinical investigations and animal experiments, obesity is correlated with reductions in sperm concentration and motility, increase in sperm DNA damage and changes in reproductive hormones. Several mechanisms can elucidate the effects of obesity on sperm functions and male subfertility, i.e., the excessive conversion of androgens into estrogens in redundant adipose tissue causes sexual hormone imbalance, subsequently resulting in hypogonadism. Secondly, adipokines produced by adipose tissue induce severe inflammation and oxidative stress in male reproductive tract, directly impairing testicular and epididymal tissues. Moreover, increased scrotal adiposity leads to increase gonadal heat, continuously hurting spermatogenesis. Therefore, obesity alters the systematic and regional environment crucial for spermatogenesis in testis and sperm maturation in epididymis, and finally results in poor sperm quality including decreased sperm motility, abnormal sperm morphology and acrosome reaction, changed membrane lipids and increased DNA damage. Furthermore, recent studies indicate that epigenetic changes may be a consequence of increased adiposity. A major effort to identify epigenetic determinants of obesity revealed that sperm DNA methylation and non-coding RNA modification are associated with BMI changes and proposed to inherit metabolic comorbidities across generations. This review will explain how obesity-related changes in males to influence sperm function and male fertility as well.
The Deinstitutionalization of Lithuanian Mental Health Services in Light of the Evidence-based Practice and Principles of Global Mental Health
Authors: Grigaitė Ugnė
Published: July 2017

During this time, in which Lithuania is going through the deinstitutionalization of its mental health services, the principles of Global Mental Health are especially relevant. This global field for study, research and practice places a priority on improving mental health outcomes as well as reducing respective inequities for all people worldwide. Scaling-up support services for persons who have mental health problems based on both scientific evidence and human rights has become one of the main focuses for action globally, and the key principles of Global Mental Health apply to the situation in Lithuania as much as they do in a number of other countries. This article explores the critical need to effectively reform the existing mental health care system in the country, which in its current form often results in human rights violations. It points to the idea, based on the global evidence base, that different Lithuanian authorities and other key stakeholders could start working together in an intersectoral way in order to reorganize mental health services from institutional to community-based models of care. It is suggested by this article that a sensible, local application of the broad key principles of Global Mental Health could be a mature and rational step taken by Lithuania. This has the potential to be a major step toward the improvement of human rights and mental health outcomes in the country.
Young People’s Voice: The First Visiting Advocacy Project in Italian Residential Care for Children
Authors: Calcaterra Valentina , Raineri Maria Luisa
Published: July 2017

This article presents the research of the project Giving Young People a Voice: Advocacy in Children’s Homes, set up as a result of the interest of a nonprofit organization working with looked-after children, with an aim to improve advocacy as a listening process and to promote the participation of children that reside in children’s homes. The research focused on the implementation of a visiting advocacy project and the activities carried out by an independent advocate working in children’s homes. The children’s evaluation of the project was collected by two focus groups; interviews were conducted with social care workers and the manager of the organization. This research deals with the implementation of the first visiting advocacy project in the context of the Italian child protection system.
Laisvalaikis ar laisvas laikas? Globos įstaigose gyvenančių vyresnio amžiaus asmenų patirtis
Authors: Charenkova Jūratė
Published: July 2017

Dėl pasitraukimo iš darbinės veiklos padidėjęs laisvo laiko kiekis esant vyresnio amžiaus gali būti panaudojamas mėgstamai veiklai, tapti tobulėjimo, naujos patirties, ramybės, džiaugsmo ar net finansų šaltiniu. Kita vertus, laisvas, darbine veikla neužimtas laikas gali kelti ir sunkumų bei nemalonių jausmų, pavyzdžiui, lemti vyresnio amžiaus asmenų nuobodulį, beprasmybės ir neturėjimo, ką veikti, jausmus. Dalyvavimas asmeniškai prasmingoje laisvalaikio veikloje vienas iš efektyviausių būdų prisitaikyti prie esant vyresnio amžiaus vykstančių pokyčių ir pagrindinių sėkmingo senėjimo veiksnių.Kokybiniame tyrime dalyvavo 6 Vilniaus miesto socialinės globos įstaigose gyvenantys vyresnio amžiaus asmenys ir 3 jose dirbančios socialinės darbuotojos. Analizuojant duomenis buvo remiamasi socialinio konstruktyvizmo ir Giddens (2000) tapatumo teorijų idėjomis. Tyrimo duomenys atskleidė, kad vyresnio amžiaus asmenų laisvalaikio samprata ir jo patyrimas skiriasi pagal individualias galimybes dalyvauti asmeniškai prasmingoje laisvalaikio veikloje. Laisvalaikio veiklos tęstinumas padeda išsaugoti tapatumo tęstinumo jausmą, dėl to svarbu sudaryti vyresnio amžiaus asmenims galimybes globos įstaigoje tęsti veiklą, kuri buvo jų mėgstama brandos amžiuje.
Reading for Our Lives
Authors: Beckwith Sarah
Published: July 2017

Jeanette Winterson's beautiful memoir Why Be Happy When You Could Be Normal? Is a biography of a reader, a book about reading—reading for your life. In addition to the Bible, there are six books in the Plymouth Brethren Winterson household, and they are all nonfiction. Jeanette's mother, Mrs. Winterson, bans the reading of fiction, so young Jeanette reads in secret, in the outside lavatory or under covers at night, carefully depositing each read book under her mattress until it floats so dangerously high that it threatens to reveal the habit considered so vicious by her mother but that is sustaining Jeanette. Mrs. Winterson reads the Bible; young Jeanette has a memory of Jane Eyre read aloud in her mother's good reading voice, but Mrs. Winterson doctors it (with the skill of a clever reader, an astute stylist) so that Jane marries St. John Rivers and goes off to the mission with him. T. S. Eliot makes her cry in Accrington Public Library because his lines “This is one moment / But know that another / Shall pierce you with a sudden painful joy” (from Murder in the Cathedral; qtd. in Winterson 39) give her hope that she will survive the moment she is in, and so does Gertrude Stein saying to Alice B. Toklas: “Right or wrong, this is the road and we are on it” (from The Autobiography of Alice B. Toklas; qtd. in Winterson 130). Jeanette Winterson claims that she “puts herself inside books for safe-keeping” and that “a tough life needs a tough language” (36, 40). The people around her have that tough language. She hears lines that she later locates in Shakespeare, a writer she regards as “not part of the alphabet, any more than black is a colour” (115). When she is homeless and living in her Mini, supporting herself at the local sixth-form college by working at the weekend market and the local library, she reads “English Literature A-Z,” in the order in which it is shelved at the Accrington Public Library (115–30). Books are home when she is homeless (61); they are doses of medicine (42), saving people from isolation and the suffering that comes from feeling that nothing about their life is recognizable to others or intelligible to themselves, from being castaways from the tribe of human.
Both/And: Critique and Discovery in the Humanities
Authors: Friedman Susan Stanford
Published: July 2017

What are the “limits of critique” in the age of trump? At a time when nationalist and proto-fascist movements are on the rise in many parts of the world? When hate-filled words and actions against the foreign, the racial or religious other, the gendered, and the differently abled are empowered to come out of the shadows and into the public realm, poisoning the atmosphere, spreading fear and despair? When corruption and greed threaten not only the foundations of democracy but also the planet on which we depend? Don't we need critique more than ever—critique of lies, of discourses and their histories, of policies and the power structures they reflect? The answer is both yes and no. Or rather, we do need critique, but we also need so much more than critique. Critique as an end in itself is not enough.
Critique and Critical Making
Authors: Jagoda Patrick
Published: July 2017

InThe Limits of Critique, Rita Felski Uses Paul Ricouer's phrase “hermeneutics of suspicion” to frame and reappraise “a diverse range of practices that are often grouped under the rubric of critique: symptomatic reading, ideology critique, Foucauldian historicism, various techniques of scanning texts for signs of transgression or resistance” (2–3). Throughout the book, she argues that literary criticism has overvalued this approach, in part because of its many affordances and pleasures. Without rejecting critique altogether, Felski concludes that “it is one way of reading and thinking among others: finite, limited, and fallible” (192).
Interrogation Over
Authors: Simpson James
Published: July 2017

Google Ngram Viewer reports that usage of the word interrogation has been climbing steadily since 1942. liberals will of course argue, not without force, that the George W. Bush administration's embrace of “enhanced interrogation” (i.e., torture) drove the recent steady rise. To that sound point one might, however, also advance a less palatable observation: that representatives of the academy were in the interrogation room, doing the interrogating, long before the Bush administration got into the act.
Autoexoticism with Promotional Purposes? Samuel-Henri Berthoud and Provincial Literary Ruse in Nineteenth-Century France
Authors: Gosetti Valentina
Published: July 2017

“There speaks the provincial!”

—Goncharov, The Same Old Story

In nineteenth-century france, the so-called province, denoting everything outside Paris, was considered a foreign land by Parisian writers, who often constructed it as an exotic space. When we deal with this kind of provincial exoticism, however, considering this perspective alone risks painting an incomplete picture of the French literary field. Through the example of Samuel-Henri Berthoud, an author from the north of France, my intention here is to shed light on autoexoticist practices by indigenous provincial writers and to explore how they actively reclaimed, fostered, and enhanced exotic constructions about their provinces. Indeed, a wealth of evidence supports my argument that their acceptance of hegemonic constructions from the dominant culture was not passive but rather an active and creative reappropriation. This essay also challenges the idea of a stable hegemonic cultural center around which the marginal authors and literary works gravitate. Before tackling these issues, let us take a step back and briefly survey the particular value of provincial France at the beginning of the nineteenth century.
Eating One's Way through Cultures: Antonin Artaud's Autoexoticist Diets and Epistemologies
Authors: Li Xiaofan Amy
Published: July 2017

That culture, diet, and epistemology are intertwined and formulate one another is a truism. But to see them as one living body inhabiting shifting perspectives that can be shed easily, like snakeskins, is an exotic view that invites further investigation. Such intriguing ideas are precisely what we find in the remarkable avant-garde writer Antonin Artaud (1896–1948). This essay traces the surprising connections between Artaud's idea of culture, the body, diet, and knowledge, arguing that Artaud outlines a notion of autoexoticism as throwing open the boundaries of one's subjectivity and culture to change and rupture.
Autoexotic Literary Encounters between Meiji Japan and the West: Sōseki Natsume's “The Tower of London” (1905) and Lafcadio Hearn's Kwaidan (1904)
Authors: Fukuzawa Naomi Charlotte
Published: July 2017

As Roland Barthes's epoch-making essay Empire of Signs suggests, in a slightly orientalist tone itself, modern japanese culture is a fascinating kaleidoscope of Eastern and Western cultures, but at the same time a strong purism is inherent in its aestheticized nationalism. In this essay, I offer a comparative literary analysis of select travel writings that emerge out of Japanese-European encounters in the Meiji era (1868–1912) to show the cultural dynamism of the time, after the Edo period (1603–1852), when Japan first opened its borders to the West. My analysis of Japan of that time as an Eastern-Western contact zone is based on Homi Bhabha's notion of cultural hybridity and Mary Louise Pratt's understanding of a cultural encounter in an asymmetrical power constellation. Japan has never been a colony, escaping Western imperialism through the (sakoku; “closed country”) policy of the shogun Tokugawa Ieyasu, who banned all Christian missionaries and Western foreigners from the insular empire. In the Meiji modernization in 1868, the old samurai elites imported select reforms from Western Europe, notably from England, France, and Germany, to Japan. This is why Yōichi Komori claimed that Japan is a “self-colonized” () culture (Posutokoroniaru 8). Through the Meiji elite's adoption of certain modern ways from Germany, France, England, and the United States, an “imitative modernity” came into being.
Autoexoticriticism
Authors: Reynolds Matthew
Published: July 2017

This collection of essays has threaded several lines of argument through and around the topic of autoexoticism. With Minyan Sun we saw how an exoticizing gaze can develop the feedback loop of autoexoticism when the self recognizes its investment in the other and subjects itself to its own desiring attention. Daniele Nunziata and Naomi Charlotte Fukuzawa both traced further complexities of identity that cross the self-other boundary in colonial Cyprus and between Britain and Japan. Peter Hill, Kasia Szymanska, and Valentina Gosetti all explored the tactical potential of autoexotic elements in a politics of representation, in locations as diverse as Syria, Poland, and Flanders. With Adriana Jacobs we found autoexoticism in recent Hebrew poetry to be a “transcreative and relational” imaginative practice. Finally, Xiaofan Amy Li argued that autoexoticism opens “the boundaries of one's subjectivity and culture to change and rupture,” creating “a holistic field of intercultural experience” where “what is considered self and other are transient and plastic,” since they are drawn into an intercultural practice that “consciously selects and re-creates elements and aspects from disparate cultures and identities.” As these accounts reveal, there can be much that is attractive in autoexoticist styles of being, of self-representation, and of encounter. They are formally and linguistically mobile. They have a strong affective charge, provoking reactions of amusement, embarrassment, or outrage. They are courageous, since they run the risk of being dismissed as mere exoticism. And they can loosen established identities, opening them to change.
Effect of steel bar corrosion on flexural behaviour through bond
Authors: Feng Qian , Visintin Phillip , Oehlers Deric J.
Published: July 2017

Steel reinforcing bar corrosion is a major concern in reinforced concrete (RC) structures. Two problems have to be tackled: determining the rate of corrosion and determining the effect of corrosion on the behaviour of the RC structure, not just at the serviceability limit but also at the ultimate limit. This paper deals with the latter, that is, the quantification of the effect of a known amount of corrosion on the flexural capacity of RC beams at the ultimate limit state. A partial interaction numerical procedure is described for quantifying the effect of corrosion at the ultimate limit state. The procedure quantifies: the flexural capacity and ductility prior to debonding – that is, while the corroded bars are still acting as reinforcement; the onset of debonding; and the flexural capacity and ductility after debonding while the corroded bars are acting as tendons. It is shown through mechanics that the onset of debonding due to corrosion is not necessarily a major or catastrophic problem as the RC beam can still have significant strength and ductility, both of which are quantifiable.
CARACTERIZAÇÃO DO DESCONFORTO FÍSICO RELACIONADO À ERGONOMIA EM PROFISSIONAIS DE ENFERMAGEM DO CENTRO CIRÚRGICO
Authors: Brito Claudia Freire , Gomes Pinheiro Livia Mara
Published: July 2017

Objetivos: Caracterizar os profissionais de enfermagem que atuam no centro cirúrgico, identificar as queixas relacionadas ao desconforto físico decorrentes de riscos ergonômicos existentes no centro cirúrgico, bem como a sua localização anatômica, caracterizar e correlacionar as queixas com o ambiente de trabalho, além de verificar o tratamento e detectar as possíveis intervenções realizadas para prevenção dos riscos ergonômicos. Metodologia: Trata-se de um estudo exploratório de natureza quanti-qualitativa. A amostra foi constituída por 22 profissionais de enfermagem que atuam em centro cirúrgico. Resultados e Discussão: A maior parte dos participantes (68,18%) respondeu que sente desconforto nos membros superiores, coluna ou nos membros inferiores, sendo que os locais mais citados como doloridos foram os ombros (18,91%), coluna (18,91%) e pernas (18,91%). Os sintomas como a dor (40,74%), dolorimento (22,22%) e cansaço (18,51%) foram as queixas mais registradas. Além disso, a maior parte dos participantes (86,36%) informou que a unidade em que atuam não promove alguma intervenção para prevenção ou tratamento dos riscos ergonômicos e mais da metade dos participantes (63,63%) informou que os problemas de desconforto que sentem estão relacionados ao trabalho no setor atual. Os profissionais sugeriram o melhor dimensionamento de pessoal e a fisioterapia preventiva como medidas importantes para prevenção de desconforto físico decorrente de problemas ergonômicos. Considerações finais: Vê-se necessidade da criação de um programa de prevenção de riscos ergonômicos no centro cirúrgico, como a estimulação da prática de atividade física, alongamentos, reeducação postural e outras atividades de fisioterapia preventiva.
El cómic underground y su relación con el Lowbrow Art / Underground comic and its relation with lowbrow art
Authors: Puga García Sonia
Published: July 2017

El arte lowbrow y el cómic underground guardan muchas similitudes. Ambos estaban creados por una juventud cansada de la sociedad en que vivían a la cual criticaban con un toque irónico. Los artistas lowbrow estuvieron influidos desde su infancia por los cómics, que sufrieron la censura en una época en la que la sociedad era muy puritana.Ni grandes editoriales, ni museos, ni galerías de arte elitistas apostaron por ellos, pero se ganaron un sitio en el mundo del arte gracias a su mensaje revolucionario que rompía con todo lo que se venía haciendo hasta ahora.Underground comic and its relation with lowbrow artLowbrow art and underground comics have many similarities. Both were created by young people tired of the society in which they lived and they criticized it with a hint of irony. Lowbrow artists were influenced by comics in their childhood, which suffered censorship at a time when the society was very puritan. No big publishers, no museums, no elitist art galleries bet on them, but they gained a place in the art world thanks to its revolutionary message that broke with everything that had been done so far.
Faz um tempo que preciso contar uma coisa... que não tive coragem de falar: livro-arte de cartas de homossexuais aos pais / Hace tiempo que tengo algo que contar..., y no me atreví a decir / It’s been a while since I have to tell you something..., ...That I did not dare say.
Authors: Boscolo Georgiadis Fernanda
Published: July 2017

Este trabajo tiene como tema la revelación  del secreto de la homosexualidad a los padres,  por medio de cartas, en un libro-arte. Se realizó un levantamiento de datos en las redes sociales, con amigos, familiares y otras personas que pudieran ceder sus correspondencias y obtener de ellas algunos retornos positivos. Del universo investigado, se entrevistó a todas las personas que escribieron cartas, cuyas edades fluctuaban entre los 18-27 años. Se trabajó con la hipótesis de que las cartas son documentos importantes, gracias a las cuales los padres toman conocimiento sobre la sexualidad de sus hijos. Conjuntamente con las entrevistas y la performance que el propio lector tendrá del libro-arte, las personas analizarán y se sentirán cercanas a esta situación. Las cartas muestran las dificultades de los homosexuales al revelar su verdadera sexualidad, como también el sufrimiento emocional, el miedo de la reacción de los padres y la dificultad como joven al contar algo que, hace mucho tiempo, está guardado como secreto. Este medio de comunicación tiene un papel muy importante en la vida de una familia, y el libro-arte es el soporte para darle el debido valor. Las investigaciones bibliográficas ayudan a entender qué es un secreto y la homosexualidad como uno de ellos. Se aborda también la homofobia en la historia, la carta como un papel importante en la revelación de la sexualidad de un joven a sus padres y cómo el libro-arte es necesario para la interacción del lector.It’s been a while since I have to tell you something..., ...That I did not dare sayThe work is a research into how the secret of homosexuality is revealed to the family, through letters in a book-art. A survey on social networks, with friends, family and others who could give his correspondence was conducted. Thus, people who identified themselves contacted. The survey universe interviews were conducted with those who wrote the letter: young 18-27 years. We hypothesized that the letters are important documents through which the family becomes aware of the sexuality of children. And along with the interviews and the timely performace that the reader will have with the book-art, people analyze and feel belonging to the situation. The letters show the difficulties of homossexual to reveal his/her true sexuality, but also the emotional distress, fear of parental reaction and the difficulty of the young count something that has long been kept secret. This medium has a very important role in the life of a family, and the book-art will be the support to give due value. The bibliographical research help to understand what is a secret and homosexuality as one. It also addresses homophobia in history, the letter as an important role in revealing the sexuality of a young man to his family and as the book-art is necessary for reader interaction.
Imaginación, creatividad y aprendizaje por descubrimiento a través del arte en Educación Infantil / Imagination, creativity and discovery learning through art in early childhood education
Authors: Rodríguez Cristino Jessica
Published: July 2017

Este artículo presenta una forma de aprendizaje a través del arte en la etapa de Educación Infantil. El arte es una herramienta crucial para lograr aprendizajes significativos y que perdurarán en  el recuerdo de los más pequeños a lo largo de toda su vida, porque ellos habrán sido los protagonistas de sus procesos de enseñanza y de aprendizaje. Se trata de desarrollar la creatividad de estos, la imaginación y la curiosidad mediante la experimentación, el aprendizaje por descubrimiento, la manipulación y el empleo de los cinco sentidos. El objetivo fundamental es presentar una manera diferente y atractiva de trabajar en las aulas cualquier contenido a través del arte mediante las “instalaciones artísticas” y formar a los educadores en ello. Una vez expuesta la parte teórica y fundamentada se presentará una investigación a través de las artes llevada a cabo durante tres meses en un aula de Infantil  de niños y niñas de entre 3 y 4 años de edad y cuya práctica real en dicho colegio llamado “Niña María” de Linares (Jaén) duró dos días. Finalmente, para concluir el trabajo se recogen  los resultados obtenidos.Imagination, creativity and discovery learning through art in early childhood educationThis article presents a way of learning through art in the kindergarten stage. Art is a crucial tool to achieve significant learning and that will last in the memory of the little ones throughout their lives because they have been the protagonists of their teaching and learning. It is about developing creativity of these, imagination and curiosity through experimentation, discovery learning, handling and use of the five senses. The main objective is to present a different and attractive way to work in the classroom any content through art by the “artistic installations” and train educators about it. Once exposed the theoretical and research based part through the arts held for three months in a classroom of children Children aged between 3 and 4 years old and whose real practice in that school will be presented called “Niña María” Linares (Jaén) lasted two days. Finally, to complete the work, the results obtained are presented.
Reseña de libro "Reflexiones sobre investigación artística e investigación educativa basada en las artes".
Authors: Cueva Ramírez María-Lorena
Published: July 2017

Reflexiones sobre investigación artística e investigación educativa basada en las artes. Moreno Montoro, María Isabel · López-Peláez Casellas, M.ª Paz (coordinadoras)
Transgressividade nos aspectos normativos recíprocos da expressão “só que não”
Authors: Gonçalves Iverton Gessé Ribeiro
Published: July 2017

Este trabalho analisa a expressão “Só que não”, presente nas gírias que circulam pelas redes sociais. O objetivo desse estudo é identificar o humor a partir da postura do locutor mediante os pontos de vista levantados pela análise argumentativa. A Teoria da Argumentação na Língua (ADL) e a Teoria dos Blocos Semânticos (TBS), desenvolvida por Ducrot (1990, 2005) e Carel (2005, 2010), compõem o aporte teórico. Procederemos à análise, partindo do princípio teórico de que as palavras não possuem valor referencial. Seu sentido só é construído a partir dos encadeamentos que possibilita ou veta a realização. O corpus deste trabalho conta com um texto disponível em redes sociais. Os procedimentos metodológicos são descritivos e bibliográficos, de abordagem qualitativa. O estudo da argumentação dos enunciados, através dos blocos semânticos, permite identificar os enunciados normativos e transgressivos recíprocos e verificar o absurdo presente nos encadeamentos argumentativos dos enunciados presumidamente humorísticos.
Climate, economy and justice — the interdependent aspects of global well-being: An analysis of develop-mental economy, climate and justice in light of its global politics
Authors: Kapur Sonia
Published: July 2017

In his book Climate, Economy, and Justice: Global Frontiers of Social Development in Theory and Practice, Brij Mohan assembled the works of a team of experts on topics such as climate change, economics and social justice. According to the author, this book explodes myths about social welfare and development and offers a critical interface between “comparative social welfare” and “new social development”.
Editorially Speaking
Authors: Mohan Brij
Published: July 2017

Environment and Social Psychology is launched as a policy, practice and research platform to encourage environmental consciousness that promotes rights of, and justice for, all including environment itself. The challenges ahead are clear. The stated mission and objectives define a paradigmatic sphere where we wish to explore, disseminate, and innovate.
Sumário
Authors: Agrogeoambiental Revista
Published: July 2017

Sumário
Perfil do desmatamento autorizado no Núcleo Regional de Regularização Ambiental de Guanhães entre 2009 e 2013
Authors: Ferraro Ana Carolina , Oliveira Rogerio Sabino de , Madeira Nildimar Gonçalves , Carellos Douglas De Carvalho
Published: July 2017

A vegetação é um dos elementos do quadro natural de maior susceptibilidade à intervenção ambiental antrópica. Na região pertencente ao Núcleo Regional de Regularização Ambiental de Guanhães, as atividades de infraestrutura, pecuária e florestal são as grandes geradoras de intervenções voltadas para o desmatamento. Essas intervenções podem ter apoio legal dos órgãos de controle. No presente trabalho, conduzido com o apoio do Instituto Estadual de Florestas (IEF), realizou-se uma análise dos processos de intervenção ambiental a fim de traçar o perfil do desmatamento entre os anos de 2009 e 2013 na referida região. Foi possível determinar importantes informações, tais como os municípios que mais pediram autorização para desmatamento, quantidade de área requerida para intervenções, desmatamento por ano e tamanho e tipo das propriedades para as quais os pedidos de intervenções são destinados. Observou-se que é de grande ocorrência o pedido de limpeza de área com aproveitamento de material lenhoso, o qual, provavelmente, é utilizado em áreas destinadas à criação de gado, confirmando, assim, a necessidade de um acompanhamento dos pecuaristas pelos órgãos responsáveis, principalmente em relação à intervenção em Áreas de Preservação Permanente (APP). Dentro do período avaliado, foram registradas grandes quantidades de pedidos e autorização para intervenção nos dois anos que antecediam a entrada em vigor do Novo Código Florestal, havendo considerável redução após a sua implementação.
Zonas de manejo em função de propriedades de solo, relevo e produtividade da lavoura cafeeira
Authors: Melo Bruno Manoel Rezende de , Paglis Carlos Maurício , Oliveira Marcelo Silva de , R. Teixeira Marcília Bruna , M. da Silva Jennifer Silva , F. Lima Daniele Fátima
Published: July 2017

O objetivo foi determinar zonas de manejo correlacionando produtividade, altitude, parâmetros de textura e fertilidade de solo em propriedades cafeeiras do sul de Minas Gerais. O experimento foi realizado em Inconfidentes (MG), em uma lavoura de café da cultivar Rubi com 0,849 ha-1, no espaçamento 2,2 m x 1,3m, em dezembro de 2011, em Latossolo Vermelho Amarelo distrófico. O local está situado a 957 metros de altitude com parte da lavoura situada no topo de morro e a outra parte em meia encosta, apresentando declividade máxima entre os pontos de maior e menor altitude de 37 %. O local para a coleta de solo está situado em cada ponto georreferenciado com um receptor GPS, para a zona 23k no sistema de referências SIRGAS 2000. Posteriormente foram analisados os parâmetros químicos, físicos, altitude e declividade da área. Para verificar a dependência espacial dos fatores em estudo, utilizou-se da geoestatística. Na presença de dependência espacial foram confeccionados os mapas de gradiente. Os resultados demonstram que não foi possível encontrar dependência espacial para o fósforo. Para as variáveis matéria orgânica, potássio, saturação de bases, pH e declividade, foi possível identificar zonas de manejo em função da correlação significativa com a altitude. A produtividade nos dois anos apresentou variabilidade espacial e temporal. Conclui-se, desta forma, que zonas de manejo podem ser identificadas correlacionando altitude com parâmetros de fertilidade. Para a produtividade e textura nos dois anos de estudos, não foram observadas zonas de manejo.
Extratos Cymbopogon citratus e Annona muricata como inibidores do crescimento micelial de fungos fitopatogênicos
Authors: Bibiano Heloísa Da Silva , Sáber Mírian Lobo
Published: July 2017

Produtos alternativos vêm sendo utilizados para manejo de fitopatógenos com extratos ou óleos essenciais. A utilização de óleos essenciais é promissora para o desenvolvimento de agentes antimicrobianos por oferecer propriedades antibacterianas e antifúngicas. O presente trabalho teve por objetivo avaliar os efeitos inibitórios in vitro do óleo essencial do capim-limão (Cymbopogon citratus) e do hidrolato de graviola (Annona muricata) sobre desenvolvimento de fungos fitopatogênicos. Os extratos vegetais foram extraídos pela técnica de arraste a vapor e testados nas concentrações de 0,05 %, 1 %, 5 %, 10 %, 15 %, 25 %, 35 %, 45 %, 50 % e 100 %. Os fitopatógenos utilizados foram Pestalotiopsis sp., Monilinia sp. e Rhizopus spp. Todos os micro-organismos foram obtidos da coleção de micro-organismos da Universidade do Vale do Sapucaí (Univás) em Pouso Alegre (MG). O óleo essencial do capim-limão inibiu o crescimento dos fungos testados nas concentrações de 50 % e 100 %. Houve inibição total do crescimento micelial de Pestalotiopsis sp. nas concentrações de 35 % a 100 %; nas concentrações abaixo de 25 %, houve inibição parcial. Com o fungo Rhizopus spp., houve crescimento parcial nas concentrações de 0,05 % a 45 %; nas concentrações de 50 % e 100 %, houve inibição total do crescimento fúngico. A Monilinia sp. obteve inibição total a partir da concentração de 35 %; abaixo da concentração de 25 %, o crescimento fúngico foi parcial. Com relação ao hidrolato da graviola (Annona muricata), os resultados indicam que não houve inibição no desenvolvimento micelial dos fungos testados, independentemente da concentração utilizada. Portanto o óleo essencial do capim-limão pode ser utilizado como alternativa ao controle desses patógenos.
Transvaginal Sonographic Cervical Length Measurement as Predictor of Preterm Delivery
Authors: Dr. Mrs. Prabha Attal Dr. Mrs. Prajakta S. Barde ,
Published: July 2017

The present study entitled, “Transvaginal Sonographic cervical length measurement as predictor of Preterm delivery” was carried out on 150 cases of primiparas who attended the Govt. Medical College, Hospital, Nagpur. The transvaginal ultrasonographic cervical length was measured at 18 -20 weeks. These cases were followed at 24 weeks and 28 to 30 weeks for pregnancy outcome as abortion, preterm labour or full term delivery. The study was carried out to correlate the outcome of pregnancy (preterm delivery) with the transvaginal cervical length measured serially at 18-20 wks, 24 wks & 28-30 wks. The mean cervical length was 41.9 at 18-20 weeks, 40.09 at 24 weeks and 37.41 at 28 to 30 weeks. The mean cervical length in patients who had preterm delivery was 22.67 at 18 to 20 weeks, 24 at 24 weeks and 18.50 at 28-30 weeks compared to 42.03, 40.3 and 32.41 respectively in those who had full term delivery. This difference was significant. The cervical length of
El transporte multimodal de mercancías en la regulación unimodal
Authors: Lizarreta Barrios Pablo
Published: July 2017

El transporte de mercancías es una operación que puede efectuarse tanto de forma unimodal como multimodal. A falta de una normativa propia, es el régimen jurídico contenido en las normas unimodales el encargado de regular las operaciones de transporte multimodal. El presente trabajo analiza los principales problemas a los que se enfrenta el transporte multimodal en el contexto legislativo actual, con especial atención a la problemática de los daños no localizados y a la reticencia que presentan los actores del tráfico al establecimiento de una normativa multimodal uniforme. Así, se estudiarán las previsiones que los distintos convenios internacionales y normas nacionales de transporte unimodal contienen sobre el transporte multimodal, haciendo hincapié en el régimen de responsabilidad aplicable al transportista, el cual varía notablemente no sólo de un modo de transporte a otro, sino también de una regulación a otra.
La comunicación horizontal y vertical en los sistemas americano y europeo de protección de derechos humanos a propósito del derecho al juez natural. Hacia un derecho global de los derechos humanos
Authors: Català i Bas Alexandre H. , Ortíz Torricos Marcela
Published: July 2017

El análisis de los sistemas americanos de protección de derechos humanos ha permitido concluir la existencia de una comunicación vertical entre el tribunal supranacional y los tribunales estatales y una comunicación horizontal entre TEDH y CIDH. Estas relaciones han de ser bidireccionales. Y en Europa ya se han detectado algún caso de influencia de la jurisprudencia de un tribunal estatal en la del TEDH. Ello no obstante, sigue siendo predominante en ambos sistemas la influencia de arriba-abajo. En cuanto a la relación entre ambos sistemas aunque se da esa bidireccionalidad, hay que destacar que es mucho mayor la influencia del TEDH sobre la CIDH. Estas afirmaciones quedan constatadas mediante el estudio del derecho al juez natural.
Diferentes concentrações de zinco no desenvolvimento de plantas de Phaseolus vulgaris L.
Authors: Menegatti Renata Diane , Pereira Aline Soares , Oliveira Luana , Dorneles Athos O. S. , Dutra Débora , Deuner Sidnei
Published: July 2017

Objetivou-se com este estudo avaliar os efeitos da aplicação de solução nutritiva com concentrações crescentes de zinco (Zn) no desenvolvimento inicial e no teor de pigmentos de plantas de feijão cultivadas em condições de casa de vegetação. O experimento foi desenvolvido no Laboratório de Nutrição de Plantas (LNP) e em casa de vegetação pertencentes ao Departamento de Botânica da Universidade Federal de Pelotas (UFPel). A semeadura foi realizada em vasos preenchidos com areia média lavada. Sete dias após a emergência das plântulas foi aplicada, com intervalos de dois dias, solução nutritiva com quatro concentrações crescentes de Zn (2, 50, 75 e 100 µM), dispostas em um delineamento experimental inteiramente casualizado com quatro repetições, sendo cada uma delas composta por seis plantas. Aos 45 dias após a emergência das plântulas, avaliaram-se as seguintes variáveis: altura das plantas, diâmetro do caule, número de folhas, área foliar e comprimento de raiz, além do índice de pigmentos fotossintéticos. Com o aumento das concentrações de Zn verificou-se decréscimo significativo para as variáveis diâmetro do caule e comprimento de raiz, sugerindo que maiores concentrações de Zn podem influenciar negativamente no desenvolvimento das plantas de feijão. Os índices de clorofila e flavonoides apresentaram elevação com o aumento das doses de Zn. Esse efeito possivelmente está relacionado a uma reação estratégica da espécie, que visa minimizar o efeito tóxico das concentrações crescentes de Zn no desenvolvimento das plantas.Palavras-chave: Feijão. Micronutriente. Pigmentos foliares. Toxicidade.
Toxicity of naphthalene in the Neotropical Fish Astyanax Lacustris (Characiformes: Characidae) and Geophagus Brasiliensis (Perciformes: Cichlidae)
Authors: Disner Geonildo Rodrigo , Calado Sabrina Louise Moraes , Silva Assis Helena Cristina , Cestari Marta Margarete
Published: July 2017

Polycyclic aromatic hydrocarbons are one of the most important organic pollutants in environmental studies. The aim of this study was to assess the naphthalene acute toxicity in two fish species, Astyanax lacustris (LLcust, 1875) and Geophagus brasiliensis (Quoy & Gaimard, 1824). The fish were exposed to naphthalene (0.005, 0.03, 0.3, and 3 mgL-1) in water and after that the piscine micronucleus test in erythrocytes, comet assay in blood, liver and gill cells, glutathione S–transferase (GST) activity in the liver, and accumulation of naphthalene in the bile were performed. The susceptibility of the two species was similar and naphthalene was not genotoxic in all tested tissues. The liver GST activity may have been responsible for less damage observed in the liver while the highest DNA damage occurred in blood cells. However, low concentrations of naphthalene in water can stimulate apparent benefits, such as less DNA damage, which would be a compensatory response to an imbalance of homeostasis. The naphthalene is absorbed and can accumulate in the gall bladder, a greater accumulation of PAH was observed in A. lacustris, while G. brasiliensis did not differ from the control. The naphthalene concentrations are not genotoxic to the tested species, although they can potentially accumulate into the body.Keywords: Comet assay. Ecotoxicology. Fish. Genotoxicity. Hormesis.
Avaliação in vitro do potencial fotoprotetor do extrato do bagaço da uva Isabel (Vitis Labrusca L).
Authors: Dengo Bruna Luiza , Notargiacomo Ferreira João Ronaldo
Published: July 2017

Neste artigo teve-se como objetivo avaliar a atividade fotoprotetora in vitro, do extrato concentrado proveniente do bagaço da uva Isabel, aplicado a uma base de gel hidrofílico, e também a caracterização de compostos presentes no extrato. As uvas são vegetais importantes, pois sua estrutura possui compostos orgânicos diversos, como o flavonoide, que é um composto que absorve luz na região do ultravioleta (UV). Como nos dias atuais as pessoas estão mais preocupadas com a saúde, elas preferem adquirir produtos de origem natural em vez de sintética, por aqueles agredirem menos a saúde. Por esse motivo é importante encontrar novos ativos vegetais que tenham a função de proteger e cuidar da pele mais naturalmente, para evitar que se tenham reações indesejáveis em razão do uso de fotoprotetores sintéticos. No presente estudo buscou-se detectar a presença de metabólitos secundários no extrato do bagaço da uva Isabel, por meio das reações gerais farmacognósticas, assim como a avaliação da sua capacidade de fotoproteção in vitro, mediante a técnica espectrofotométrica. O extrato do bagaço da uva Isabel mostrou-se capaz de incrementar o FPS de formulações cosméticas em base de gel hidrofílico e apresentou-se preliminarmente estável em um período de 30 dias, à temperatura ambiente (15 ºC a 30 ºC).Palavras-chave: Protetor solar. Extratos vegetais. Antioxidante. Uva Isabel. Vitis Labrusca L.
EDITORIAL 2017_1
Authors: Gelinski Jane Lafayette Neves
Published: July 2017

Nesta primeira edição da Evidência Ciência e Biotecnologia de 2017, quatro trabalhos foram cuidadosamente selecionados pelos avaliadores face sua relevância e multidisciplinaridade. São estudos que tem um viés com a biotecnologia ambiental, desenvolvimento e sustentabilidade. O primeiro trata-se da utilização de duas espécies de peixe Astyanax lacustris (Lütken, 1875) e Geophagus brasiliensis (Quoy & Gaimard, 1824) como bioindicadoras de contaminantes de água por naftaleno, um hidrocarboneto policíclico aromático (HPA), o qual é um potencial agente mutagênico e carcinogênico. No segundo, o objeto de estudo  é a recuperação de áreas contaminadas por metais pesados a partir de métodos de revegetação. Neste, são avaliados os efeitos da aplicação de diferentes concentrações de Zinco no desenvolvimento de plantas de feijão cultivadas em casa de vegetação.A partir de uma tendência mundial voltada ao desenvolvimento de novos produtos nas áreas de alimentos, biocosméticos, fármacos e outros e,  na perspectiva da sustentabilidade, duas contribuições cientificas foram publicadas. A primeira segue na linha de novos produtos alimentícios com apelo funcional. Nesta foram desenvolvidos cookies com adição de farinha de casca de batata (FCB) destacando-se a formulação com teor de fibras de 8,5%, com boa aceitação sensorial e expectativa favorável à comercialização. A segunda contribuição descreve o desenvolvimento de produtos cosméticos com formulação rica em polifenóis de origem vegetal. A pesquisa traz dados sobre o efeito potencial fotoprotetor do extrato do bagaço da uva Isabel (Vitis Labrusca L), avaliando-se constituintes polifenólicos do bagaço de uva e sua capacidade fotoprotetora.Agradecemos aos avaliadores (referees) desta seleção de artigos via sistema double blind review.Convidamos todos os pesquisadores à submissão de trabalhos científicos em nosso Periódico Evidência – Ciência e Biotecnologia que segue no recebimento de artigos em fluxo contínuo para a próxima edição.