bluuebunny/crossref_metadata_2025 huggingface dataset:
Mechanisms of Cold Preservation and Reperfusion Injury for Solid Organ Transplantation: Implications for Partial Heart Transplantations
Authors: Mealer Corey , Konsek Haley , Travis Zachary , Suk Rebecca N. , Rajab Taufiek Konrad
Published: July 2023

Cold preservation is a key component to organ procurement and transplantation. Cold preservation functions by slowing metabolic activity of procured organs and begins the period known as cold ischemic time (CIT). Reducing CIT and warm ischemic time (WIT) are paramount to minimizing donor organ damage from ischemia and the build-up of waste products and signals that drive reperfusion injury prior to transplantation into a matching recipient. Preventing damage from CIT and WIT and extending the amount of time that organs can tolerate has been a major goal of organ transplantation since donors and recipients are frequently not located within the same hospital, region, or state. Meanwhile, the amount of CIT that a transplant center is willing to accept differs based on the organ, the institution receiving the organ offer, and the doctor receiving the offer for that institution. With the introduction of a partial heart transplantation conducted last year at Duke University, it is important to discuss how much CIT transplant centers conducting a partial heart transplantation (pHT) are willing to accept. This article will review the physiology of WIT and CIT, associated organ damage, CIT variation among transplant centers and organ types, and provide a brief discussion of the future of pHT-accepted CIT and the need for research in this field.
Quantum Mechanics and Quantum Field Theory: Algebraic and Geometric Approaches
Authors: Frolov Igor , Schwarz Albert
Published: July 2023

This is a non-standard exposition of the main notions of quantum mechanics and quantum field theory, including recent results. It is based on the algebraic approach in which the starting point is a star-algebra and on the geometric approach in which the starting point is a convex set of states. Standard formulas for quantum probabilities are derived from decoherence. This derivation allows us to go beyond quantum theory in the geometric approach. Particles are defined as elementary excitations of the ground state (and quasiparticles as elementary excitations of any translation invariant state). The conventional scattering matrix does not work for quasiparticles (or even for particles if the theory does not have particle interpretation). The analysis of scattering in these cases is based on the notion of an inclusive scattering matrix, which is closely related to inclusive cross-sections. It is proven that the conventional scattering matrix can be expressed in terms of Green functions (LSZ formula) and the inclusive scattering matrix can be expressed in terms of generalized Green functions that appear in the Keldysh formalism of non-equilibrium statistical physics. The derivation of the expression of the evolution operator and other physical quantities in terms of functional integrals is based on the notion of the symbol of an operator; these arguments can be applied in the geometric approach as well. In particular, this result can be used to provide a simple derivation of the diagram technique for generalized Green functions. The notion of an inclusive scattering matrix makes sense in the geometric approach, although it seems that a definition of the conventional scattering matrix cannot be provided in this situation. The geometric approach is used to show that quantum mechanics and its generalizations can be considered as classical theories where our devices are able to measure only a part of the observables.
Control Strategy of Torque Distribution for Hybrid Four-Wheel Drive Tractor
Authors: Yan Xianghai , Zhang Hui , Li Xianzhe , Li Yanying , Xu Liyou
Published: July 2023

Based on the analysis of the operating conditions of the tractor, a Hybrid four-wheel drive tractor is proposed, and formulate the torque distribution control strategy based on fuzzy control, to control the driving wheel slip rate of the Hybrid four-wheel drive tractor in the high traction efficiency operating range of the tractor. The vehicle model of the Hybrid four-wheel drive tractor is established in AVL-CRUISE software, and the torque distribution control strategy based on fuzzy control is established in MATLAB/Simulink software. The AVL-CRUISE and MATLAB/Simulink co-simulation was carried out based on the plowing condition of the tractor. The simulation results show that the torque distribution control strategy based on fuzzy control can control the driving wheel slip rate of the Hybrid four-wheel drive tractor in the high traction efficiency operating range, the power performance of the Hybrid four-wheel drive tractor is improved, while the engine runs smoothly and is always in the high-efficiency range of engine operation, and the economy is better.
Dementia care coordinator service in Kent and Medway: a realist evaluation protocol
Authors: Abrams Ruth , Gage Heather , Maben Jill , Grosvenor Wendy , Sykes Kath , Touray Morro
Published: July 2023

Background

Dementia care is a key priority for both NHS England and the UK government. National guidelines highlight the importance of care coordination to address the challenges people living with dementia and their carers can encounter when trying to access the health and care system. To counter these challenges, Kent and Medway Integrated Care Board (ICB) have recently implemented a proactive dementia care coordinator (DCC) service to support people with dementia and their carers from pre-diagnosis to end-of-life care.

Aim

To understand how the DCC service works (or does not work), for whom, and in what circumstances. The findings will inform service development and future investment decisions.

Design & setting

This study will use a realist approach to evaluate the DCC service in Kent and Medway ICB, south-east England, which has a population of 1.9 million, comprising 42 primary care networks (PCNs; groups of general practices) each having a DCC.

Method

An initial programme theory will be developed from existing literature, and in collaboration with stakeholders. Mixed methods, including questionnaires to DCCs, service provider metrics, and qualitative interviews, will be used to collect data on service provider and service user experiences. Interpretive comparative analysis and narrative synthesis, including evaluation of service costs against outcomes, will produce a refined final programme theory.

Results

The results from this project will produce evidence-based recommendations to help improve service delivery and possible service expansion.

Conclusion

This protocol describes a realist evaluation designed to investigate the recently implemented DCC service in Kent and Medway ICB.
SOCIAL NETWORK ANALYSIS OF TADOM HILL, BANTING, SELANGOR AND THE IMPLICATIONS UPON IT’S MANAGEMENT
Authors: Abdullah Siti Mariam Mellisa , Zakaria Nurhidayah , Ya’acob Fatin Farazh , Haji Othman Mohd Shahwahid
Published: July 2023

Purpose - Community-based management practice is set as an illustration of how local stakeholders participation many problems and dilemmas in connection with governing ecotourism could be better resolved. A case study of Tadom Hill (TH) in Banting, Selangor has been facing complaints from the local indigenous community concerning the governance of the resort. The aim of this study to identify the stakeholders, their roles in the social network of TH, characterize their relationships between them and establish the effects on governance issues at TH. Design- A survey was administrated to different groups of stakeholders who has connection with TH in order to characterize the relationships between them and establish their effects on governance issues at TH. Methodology - Social Network Analysis (SNA) method was used to identifies the key stakeholders and their roles in the social network of TH. Findings - The results gained from the SNA has provided greater thorough information of the top-down management approach at the resort. For a resort to be efficiently managed, effective involvement of the stakeholders is essential. Conclusion - It was concluded that the management of the ecotourism services at TH need the involvement of local stakeholders in the pursuit of greater co-management at the resort.
EVALUATING THE ROLE OF FORESTED AREA, AGRICULTURAL LAND, ENERGY CONSUMPTION AND FOREIGN DIRECT INVESTMENT ON CO2 EMISSIONS IN INDONESIA
Authors: Keh Chia-Guan , Tan Yan-Teng , Tang Siu-Eng , Sim Jia-Jia , Lee Chin-Yu
Published: July 2023

Environmental concerns have steadily gained attention as the economy has grown more rapidly. This ultimately impedes the growth of a high-quality economy. Several factors, namely forested area, agricultural land, energy consumption and foreign direct investment, have contributed significantly to economic expansion while simultaneously deteriorating the environment in the short and long run. Hence, this study empirically examines the effect of forested area, agricultural land, energy consumption and foreign direct investment on CO2 emissions in the case of Indonesia from 1990 to 2020 by employing the autoregressive distributed lags (ARDL) approach. The results indicate that forested area negatively and significantly impacts CO2 emissions in the short and long run. However, agricultural land, energy consumption and foreign direct investment positively influence CO2 emissions in the long run. Moreover, agricultural land and foreign direct investment demonstrate a negative relationship with CO2 emissions, whereas energy consumption positively affects CO2 emissions in the short run. Thus, the results are insightful for policymakers to develop efficient strategies to reduce carbon emissions and eradicate environmental deterioration in Indonesia.
COLGAJO DE MUSTARDÉ COMO TRATAMIENTO DE UN CARCINOMA BASOCELULAR. A PROPÓSITO DE UN CASO.
Authors: Fuenzalida Mery Lucas , Villalobos Cabrera Keilo Tomás , Miranda Palta Rodrigo , Cabané Toledo Patricio Eduardo
Published: July 2023

Introducción: El carcinoma basocelular es actualmente el cáncer de piel más frecuente, siendo su principal factor de riesgo la exposición a radiación ultravioleta. Su tratamiento es la resección quirúrgica, según riesgo de recurrencia. La reconstrucción facial posterior a la resección se enfrentará según la unidad estética de la cara, lo cual determinará la técnica quirúrgica a utilizar.Materiales y Métodos: El siguiente caso clínico aborda la resección de un carcinoma basocelular nodular morfeiforme ubicado en mejilla y ala nasal, y posterior reconstrucción mediante el uso de un Colgajo de Mustardé, con resultado exitoso.Resultados: Evolución favorable, con reseccion completa de la lesion tumoral y vitalidad del colgajo postoperatorio. Cursó con una leve desviación nasal que cedió con masaje de la cicatriz. Se puede plantear una plastía de retoque del ala nasal a  futuroConclusión: Presentamos un caso clínico de un carcinoma basocelular facial con alto riesgo de recurrencia que fue tratado en forma segura y efectiva con un colgajo de Mustardé.
A RARE CASE OF GUILLAIN-BARRE SYNDROME PRECIPITATED BY VARICELLA ZOSTER VIRUS (VZV) INFECTION
Authors: M Ishaivanan. , V Padma.
Published: July 2023

Varicella zoster infection followed by polyradiculopathy is rare and
happens in the reactivation of latent varicella roster virus (vzv).we
report a case of polyradiculopathy triggered by varicella zoster
infection
СТАН, ПРОБЛЕМИ ТА НАПРЯМИ ДОСЛІДЖЕНЬ У ГАЛУЗІ ВІТРОЕНЕРГЕТИКИ – ЗА МАТЕРІАЛАМИ НАУКОВО-ПРАКТИЧНОЇ КОНФЕРЕНЦІЇ «ВІДНОВЛЮВАНА ЕНЕРГЕТИКА ТА ЕНЕРГОЕФЕКТИВНІСТЬ
Authors: Коханєвич В. П.
Published: July 2023

Метою роботи є аналіз актуальних проблем відновлюваної енергетики, зокрема вітроенергетики, за результатами матеріалів ХXIV Міжнародної науково-практичної конференції «Відновлювана енергетика та енергоефективність у ХХІ столітті». Розглянуто тези доповідей та проаналізовано основні досягнення за такими основними напрямами: оцінка сучасного стану вітроенергетики України; оцінювання вітро­­­потенціалу та прогнозування виробітку електроенергії вітроелектричною установкою; теоретичні дослідження; стан вітроустановок та засоби їх діагностування; електроенергетичне обладнання вітроустановок; перспективні та нетрадиційні вітроустановки. Окреслено перспективи та напрями подальших досліджень та заначено, що незважаючи на те, що Україна перебуває в стані війни, розвиток вітроенергетики в Україні відбувався як у плані будівництва нових ВЕС, так і подальших наукових досліджень.
An Insurance Value Modeling Approach That Captures the Wider Value of a Novel Antimicrobial to Health Systems, Patients, and the Population
Authors: Chan Mei S. , Holloway Richard , King Robert , Polya Rosie , Sloan Rebecca , Kowalik Jack C. , Ashfield Tom , Moore Luke S.P. , Porter Thomas , Pearson-Stuttard Jonathan
Published: July 2023

Background: Traditional health economic evaluations of antimicrobials currently underestimate their value to wider society. They can be supplemented by additional value elements including insurance value, which captures the value of an antimicrobial in preventing or mitigating impacts of adverse risk events. Despite being commonplace in other sectors, constituents of the impacts and approaches for estimating insurance value have not been investigated.

Objectives: This study assessed the insurance value of a novel gram-negative antimicrobial from operational healthcare, wider population health, productivity, and informal care perspectives.

Methods: A novel mixed-methods approach was used to model insurance value in the United Kingdom: (1) literature review and multidisciplinary expert workshops to identify risk events for 4 relevant scenarios: ward closures, unavoidable shortage of conventional antimicrobials, viral respiratory pandemics, and catastrophic antimicrobial resistance (AMR); (2) parameterizing mitigable costs and frequencies of risk events across perspectives and scenarios; (3) estimating insurance value through a Monte Carlo simulation model for extreme events and a dynamic disease transmission model.

Results: The mean insurance value across all scenarios and perspectives over 10 years in the UK was £718 million, should AMR remain unchanged, where only £134 million related to operational healthcare costs. It would be 50%-70% higher if AMR steadily increased or if a more risk-averse view (1-in-10 year downside) of future events is taken.

Discussion: The overall insurance value if AMR remains at current levels (a conservative projection), is over 5 times greater than insurance value from just the operational healthcare costs perspective, traditionally the sole perspective used in health budgeting. Insurance value was generally larger for nationwide or universal (catastrophic AMR, pandemic, and conventional antimicrobial shortages) rather than localized (ward closure) scenarios, across perspectives. Components of this insurance value match previously published estimates of operational costs and mortality impacts.

Conclusions: Insurance value of novel antimicrobials can be systematically modeled and substantially augments their traditional health economic value in normal circumstances. These approaches are generalizable to similar health interventions and form a framework for health systems and governments to capture broader value in health technology assessments, improve healthcare access, and increase resilience by planning for adverse scenarios.
Congestão Pulmonar em Insuficiência Cardíaca com Fração de Ejeção Reduzida: Comparação Entre o Ultrassom de Pulmão e o Dispositivo Dielétrico Remoto
Authors: Otto Maria Estefânia Bosco , Esmanhoto Vanessa Andreoli , Correia Edileide de Barros , Murta Ana Cristina de Souza , Bruscky Larissa Ventura Ribeiro , Vilela Andrea de Andrade , Paladino Antonio Tito , Assef Jorge Eduardo
Published: July 2023

Introdução: A avaliação de congestão pulmonar ambulatorial em pacientes com insuficiência cardíaca com fração de ejeção reduzida (ICFER) pode minimizar internações por descompensação e otimizar o uso de diuréticos.

Objetivo: Comparar o dispositivo dielétrico remoto (DDR), equipamento validado para detectar líquido extravascular pulmonar, com parâmetros clínicos, medidas de ecocardiograma transtorácico (ETT) e ultrassom de pulmão (ULSP).

Métodos: Incluímos 38 pacientes do ambulatório de miocardiopatias (63±12 anos; 21 homens). Todos foram submetidos, num período de 24 horas, à avaliação clínica com descrição de dispneia paroxística noturna, edema de membros inferiores (EMI), presença de tonturas; avaliação laboratorial de NT-ProBNP; avaliação pelo DDR e ETT com análise de parâmetros de congestão sistêmica pela veia cava inferior, função do ventrículo direito e de congestão pulmonar, como a avaliação das pressões de enchimento por meio E/e’ médio e volume indexado do átrio esquerdo.
O ULSP foi realizado com o protocolo de 8 quadrantes anteriores, com contagem de linhas B em um ciclo respiratório.

Resultados: 22 pacientes apresentavam DDR ≥ 35% (congestão pulmonar) e 16 pacientes DDR < 35%. Parâmetros clínicos e ecocardiográficos foram comparados com o DDR ≥ 35%. Na análise multivariada, as variáveis superfície corpórea (SC), linhas B e EMI se associaram a DDR ≥ 35%. NT-ProBNP foi semelhante e elevado em ambos os grupos.

Conclusões: O acompanhamento ambulatorial de ICFER para controle volêmico pode ser sensibilizado pela presença de linhas B no ULSP, que apresenta boa correlação com DDR ≥ 35%. NT-ProBNP não foi capaz de diferenciar pacientes com maior grau de congestão detectado pelo DDR.
PENGARUH PERBEDAAN SUHU DAN WAKTU PENGERINGAN TERHADAP KARAKTERISTIK IKAN ASIN SEPAT SIAM (Trichogaster pectoralis) DENGAN MENGGUNAKAN OVEN
Authors: Riansyah Angga , Supriadi Agus , Nopianti Rodiana
Published: July 2023

The researce objective was to the effect of different drying temperatures and times on the characteristics of fish salted Siamese gourami (Trichogaster pectoralis) using oven. This research was conducted on October until November 2012 in the Fishery Processing Technology Laboratory, Faculty of Agriculture and Bioproses Laboratory, Faculty of Engineering, Sriwijaya University of Indralaya. The research used Factorial Randomized Completely Block design with 3 difference drying temperature and 5 difference time then 2 replicated. The treatment of temperature (50oC, 60oC and 70oC) and time (0, 6, 12, 18 and 24 hours). Parameters observed were moisture content, ash content, fat content, protein content, carbohydrate content, hedonic quality test : appearance, aroma, flavor and texture. The results showed that the difference drying temperature and drying time was significant on moisture content, ash content, fat content, protein content, carbohydrate content, hedonic quality test : appearance, aroma, flavor and texture. Interaction of kinds of different drying temperatures and times had significant effect on moisture content, ash content, protein content and carbohydrate content. The best treatment was combination of T3t2 with oven temperature 70Â°C for 12 hours with moisture content 39.05%, ash content 6.85%, protein content 42.41 %, fat content 10.22%, carbohydrate content 1.66%, appearance 7.8, aroma 7.08, and flavor 7.08 and texture 7.82
ANALISIS KORELASI HARGA TERHADAP WARNA DAN MUTU SENSORIS KEMPLANG IKAN GABUS (Channa striata) DI PASAR CINDE PALEMBANG
Authors: Octavianus Toni , Supriadi Agus , Hanggita Siti
Published: July 2023

This study aims to investigate the characteristics of color and sensory quality fish crackers at some price ranges and also to determine the relationship between price and color characteristics and sensory quality fish crackers on retailers who are market at Cinde Palembang. This research was conducted at the Laboratory of Fishery Product Technology, Laboratory of Agricultural Technology Faculty of Agriculture, Laboratory of Bioprocess Engineering Chemistry Indralaya Sriwijaya University in April 2014 until May 2014. The research method in this study is a exploratory experiments, with three price categories (low, medium and high). Parameters observed are color characteristic and quality sensory (scents, color, crispness and flavor). The results showed a strong correlation in chroma, scents and flavor. As for the correlations that medium found in the color and crispness. The results of a low correlation with the level of relationship contained in lightness and hue
PENGARUH PENGGUNAAN BAHAN AJAR KIMIA DASAR MATERI KINETIKA KIMIA BERBASIS STEM-PROBLEM BASED LEARNING TERHADAP HASIL BELAJAR MAHASISWA PENDIDIKAN KIMIA UNIVERSITAS SRIWIJAYA
Authors: Putri Siska , Suhery Tatang , Sari Diah Kartika , Edi Rodi
Published: July 2023

Penelitian ini dilakukan dengan tujuan untuk mengetahui pengaruh penggunaan bahan ajar kimia dasar  berbasis STEM-Problem Based Learning materi kinetika kimia terhadap hasil belajar mahasiswa Pendidikan Kimia Universitas Sriwijaya. Penelitian ini merupakan penelitian eksperimen semu dengan non-equivalent control group design. Teknik pengumpulan data pada penelitian ini adalah tes, lembar observasi, dan wawancara. Uji persyaratan analisis pada penelitian ini meliputi uji homogenitas dan normalitas. Uji hipotesis yang dilakukan adalah independent sample t test, dengan membandingkan nilai thitung dengan ttabel. Dari hasil uji t tersebut diperoleh nilai thitung 15,233 > ttabel 1,998, sehingga H0 ditolak. Dengan demikian dapat disimpulkan bahwa bahan ajar kimia dasar materi kinetika kimia berbasis STEM-Problem Based Learning memberikan pengaruh positif terhadap hasil belajar mahasiswa, dan dapat secara efektif digunakan dalam proses belajar mengajar.
PRaG regimens for rechallenge in a patient with acquired resistance to PD-1 inhibitor in advanced refractory renal pelvis carcinoma: A case report
Authors: Hong Zhihui , Xu Hong , Kong Yuehong , Xu Meiling , Ma Yifu , Xing Pengfei , Zhang Liyuan
Published: July 2023

Despite the burgeoning popularity of programmed death-1 (PD-1) inhibitors in cancer treatment, it is not uncommon for patients who initially respond to this therapy to experience relapse over time. Here, we present the case of a patient with advanced renal pelvis carcinoma who had received prior treatment with chemotherapy and PD-1 inhibitor therapy but ultimately experienced disease progression. Subsequently, the patient underwent a combination therapy known as PRaG 2.0, which included PD-1 inhibitor, radiotherapy, granulocyte-macrophage colony-stimulating factor, and interleukin-2, resulting in effective disease control without significant adverse events. The duration of disease control lasted for a period of 10 months.
Управління інноваційним розвитком закладу загальної середньої освіти на основі організованої синергії
Authors: Назаренко Людмила
Published: July 2023

У статті на теоретико-методологічному рівні досліджено концепцію управління інноваційним розвитком загальноосвітнього навчального закладу на основі позитивної організованої синергії. На основі самостійно сформованих наукових позицій обґрунтовано, що концепція позитивної організованої синергії є основою управління інноваційним розвитком закладу загальної середньої освіти шляхом забезпечення необхідних умов формування внутрішньої самоорганізації, вироблення і застосування механізмів її стимулювання і підтримки з метою досягнення певного синергетичного ефекту для поліпшення ефективності виконання спільної мети, завдань, функцій у процесі інноваційних змін.

Визначено умови формування самоорганізації в різних підсистемах освітньої діяльності, а саме:  розвиток внутрішньої активності професійних груп, реалізація політики відкритих комунікацій, виокремлення в структурі закладу освіти відносно автономних підсистем. Доведено, що забезпечення означених вище умов сприятиме не лише чуттєво-емоційному, а й когнітивному сприйняттю нових професійних завдань, формуванню діяльної поведінки за типом «активне самозалучення» (перша умова); реалізації політики відкритих комунікацій, що необхідно для ефективного інформаційного обміну між «суб’єктами творення змін», швидкого прийняття правильних управлінських рішень, злагодженості роботи всього колективу (друга умова); делегуванню певних повноважень для виконання особливо важливої місії та забезпечення координації їх взаємодії (третя умова).
Redesign of the validation framework in LinkML
Authors: Unni Deepak , Waagmeester Andra , Labra-Gayo Jose Emilio
Published: July 2023

LinkML is a data modeling language that can be used to describe the structure and semantics of data from a specific domain. But as with any modeling language, there is a need for tools that support validation of data. The LinkML provides a set of validation tools but there is a growing need to adapt the tools for a broader audience. The work highlighted in this report describes the efforts of redesigning the validation framework in LinkML to better support a wider range of validation scenarios and use cases.
Forecasting the Performance of PT Pertamina’s Petrochemical Products During the Covid-19 Pandemic Era
Authors: Waljiyanto Waljiyanto , Musadieq M. Al , Yulianto Edy , Abdillah Yusri
Published: July 2023

The industrial sector is a vital sector in economic development and growth in Indonesia. The industrial sector is also a dominating energy user. This research purposed to examine projected demand for petrochemicals after the COVID-19 pandemic. This study was a quantitative research with the exploratory and descriptive approach; spesifically using forecasting methods (Vector Autoregressive (VAR)). VAR is a multivariate forecasting model used to build a forecasting system from interrelated time series data. The results of the analysis prediction shows that the demand for petrochemicals will increase starting in 2021. The risk impact caused by COVID -19 is estimated to be more significant, with Petrochemical products are Aromatic 45%, Bitumen 45%, and Special Chemical 41%. The effect of COVID-19 in reducing the economy causes the industry to reduce the amount of production.
Antibiotic Potential of Marine Actinomycetes of the Genera Streptomyces and Nocardiopsis
Authors: Sineva O. N. , Sadykova V. S. , Bychkova O. P. , Ivankova T. D. , Malysheva K. V. , Markelova N. N.
Published: July 2023

Due to the emergence of antibiotic resistance in pathogenic microorganisms, it is urgent to search for producers of new antimicrobial metabolites. Actinomycetes are gram-positive mycelial bacteria that produce a large number of antibiotics used in medicine and the agro-industrial complex. Currently, researchers are focused on the search for actinomycetes in ecological niches such as freshwater and marine reservoirs, zones with extreme natural conditions (permafrost soils, glaciers, desert, saline soils, etc.). In this study, cultures of marine actinomycetes were restored after 15 years of storage under vaseline oil. It was shown that all strains retained viability and antibiotic activity at a high level. Based on the results of 16S rRNA gene sequence analysis, the species were identified as: Streptomyces sampsonii 6N, Streptomyces sampsonii 8N, Streptomyces sampsonii 521N, Streptomyces halstedii 22N, Streptomyces brevispora 12N, Streptomyces hirsutus 23N, Streptomyces niveus 14N, Nocardiopsis alba 24N, Nocardiopsis alba 73N, Nocardiopsis alba 85N, Nocardiopsis alba 106N, Nocardiopsis alborubida 722N, Nocardiopsis umidischolae 755N, Nocardiopsis umidischolae 763N. These strains of actinobacteria possessed significant antibiotic activity against the following pathogens: Micrococcus luteus ATCC 9341, Staphylococcus aureus INA 00985, Bacillus subtilis ATCC 6633, Staphylococcus aureus INA 00761 (MRSA — Staphylococcus aureus), Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, Pectobacterium carotovorum VKM-B1247, Saccharomyces cerevisiae INA 01042, Candida albicans ATCC 14053, Aspergillus niger ATCC 16404, Aspergillus fumigatus CPB F -37, Fusarium solani VKPM F-890, Fusarium oxysporum VKPM F-148. Therefore, this study evaluated the marine actinomycetes can be potential producers of the novel antibiotics.
Association of the Estrogen Receptors Beta Expression with the Ki-67 Proliferative Index in Breast Cancer
Authors: Bogush T. A. , Potselueva P. D. , Scherbakov A. M. , Bogush E. A. , Ravcheeva A. B. , Vikhlyantseva N. O. , Kosorukov V. S.
Published: July 2023

Background. Estrogen receptors beta (ERβ) are an important biological regulator and target of antiestrogens, however, unlike estrogen receptors alpha (ERɑ), their significance in the prognosis and treatment of breast cancer remains unclear. Purpose. Evaluation of the ERβ prognostic value in the comparative assessment of frequency and level of the marker expression in groups with good and poor prognosis by Ki-67 proliferative index score in breast cancer. Methods. ERβ expression level (% of cells expressing the marker) in 68 breast tissue samples was quantified by immunofluorescence and flow cytometry. Primary antibodies to ERβ (clone 14C8, ab288) and secondary antibodies conjugated with DyLight650 (ab98729) were used. In the same samples, the Ki-67 expression level was assessed by the immunohistochemical method. Results. The ERβ and Ki-67 were detected in 100% breast tissue samples with high heterogeneity of the markers’ expression in different patients. Statistical analysis of good and poor prognosis in accordance with the Ki-67 proliferative index score (Ki-67≤20% and Ki-67>20%) showed the prognostic value of the ERβ expression level of 50%. There was no association between the Ki-67 and ERβ expression levels in the same tumor sample (Spearman's rank correlation coefficient R=–0,16; P>0,05). At the same time, high expression of ERβ≥50% was 2,3 times more frequently detected in the good vs poor prognostic group by Ki-67 — 41% vs 18%, P=0,02. Conclusion. The ERβ expression level ≥50% in the tumor can be considered as a factor of good prognosis of breast cancer.
Study of the Mechanism of Antiviral Activity of Cytovir®-3 Against Respiratory Viruses In Vitro
Authors: Zarubaev V. V. , Smirnov V. S. , Kudryavtseva T. A. , Petlenko S. V. , Slita A. V. , Minh H. , Zaplutanov V. A.
Published: July 2023

Introduction. The requirements of modern clinical guidelines for the treatment of respiratory viral infections suggest the possibility of identifying a specific viral pathogen. In this regard, the search for drugs with selective activity against respiratory syncytial virus and parainfluenza virus is relevant. The purpose of the work is to study the antiviral activity of the drug Cytovir®-3 in vitro in relation to the cytopathogenic effect of respiratory viruses (parainfluenza virus and respiratory syncytial virus). Material and methods. The antiviral effect of Cytovir®-3 in comparison with Umifenovir against parainfluenza virus and respiratory syncytial virus was studied on Vero cell culture. Drugs were administered 1 hour before (prophylactic regimen) and 1 hour after (treatment regimen) infection of the cell culture with respiratory viruses. The working range of concentrations of the studied drugs was calculated based on the values of 50% cytotoxic concentration calculated based on the results of a quantitative microtetrazole test. Results and discussion. The drug Cytovir®-3 in two schemes of application (therapeutic or prophylactic) showed its antiviral efficacy in vitro against respiratory syncytial virus and parainfluenza virus due in the non-toxic range (0–794 µg/ml). At the same time, the suppressive effect of the drug Cytovir®-3 against the parainfluenza virus begins at lower concentrations of the drug with its early (preventive) introduction into cell culture (250 mcg/ml). Conclusion. Antiviral activity of Cytovir®-3 has been proven in vitro against parainfluenza virus and respiratory syncytial virus. At the same time, in all series of experiments, Cytovir®-3 had a higher index of selectivity of antiviral action than that of the comparison drug Umifenovir.
A Systematic Review with Meta-Analysis and Indirect Comparison of the Effectiveness of COVID-19 Anti-Interleukin Therapy
Authors: Gomon Yu. M. , Kolbin A. S. , Fahrutdinova A. M. , Usmanova T. A. , Sultanova F. M. , Balykina Yu. E.
Published: July 2023

Aim. Evaluation of the effectiveness of anti-interleukin drugs used in the pathogenetic therapy of COVID-19 in relation to the relative risks of 28-day mortality and the odds ratio of 14-day improvement of symptoms of the disease. Materials and methods. A systematic review of publications concerning the evaluation of the effectiveness of these drugs recommended for use as COVID-19 pathogenetic therapy, with meta-analysis and indirect comparison of the data obtained, was carried out. Results. The meta-analysis included 15 randomized and 8 non-randomized studies. In direct comparison of anti-interleukin drugs with controls, it was demonstrated that only tocilizumab and anakinra surpass standard therapy in terms of the relative risk of 28-day mortality (RR 0.85 [95% CI 0.74; 0.97] and 0.5 [95% CI 0.32; 0.80], respectively). Statistically reliable data were also obtained in favor of the effectiveness of levilimab in comparison with standard therapy according to the criterion of «improvement by the 14th day of the disease», which was 2.29 [1.31; 4.01]. With an indirect comparison of tocilizumab and anakinra, the latter showed greater effectiveness in reducing the 28-day mortality rate: the RR was 1.2 [95% CI 1.16; 1.25], P=0.0001. Conclusion. The meta-analysis of the results of the systematic review demonstrated the effectiveness of tocilizumab and anakinra in relation to the 28-day mortality rate, and levilimab in relation to the indicator «Improvement by the 14th day of the disease».
Substantiation of the Combined Use of Negative Pressure Therapy and Meglumine Sodium Succinate in the Treatment of Wounds of Various Etiologies
Authors: Varganov M. V. , Miklichev A. A. , Svidersky I. V.
Published: July 2023

The review presents a theoretical rationale for the effectiveness of including topically NPWT therapy and meglumine sodium succinate intravenously in the complex therapy of wounds of various etiologies. The biochemical pathways accompanying the formation of normoxia and hypoxia of varying severity, the significance of succinate in their formation, including depending on the form of its intake into the body (exogenous and endogenous pathways), are given. Thus, when endogenous production of succinic acid is decompensated, the tricarboxylic acid cycle is inhibited and anaerobic glycolysis is activated. At this moment and before the onset of irreversible biochemical damage, the restoration of energy exchange processes begins to depend on succinate, including its exogenous intake. Additional, but no less important, antihypoxic effects of exogenous succinate include stimulation of succinate oxidase oxidation of succinic acid with the restoration of its consumption in the mitochondrial respiratory chain and an increase in the activity of the antioxidant function of glutathione, as well as stimulation of protein metabolism. Reamberin (meglumine sodium succinate) significantly accelerates tissue recovery during hypoxia due to its antihypoxic, cytoprotective and other effects due to the activation of HIF-1ɑ biologically active factors.
Influence Of Compensation, Leadership Style, Work Environment, And Perceptions Of Job Opportunities On Turnover Intention at PT. VALBURY ASIA FUTURES SEMARANG
Authors: Sari Septi Wulan , Setiawati Ira , Indriasari Ika , Sumartono Eko
Published: July 2023

This study aims to analyze the effect of compensation, leadership style, work environment, and perceptions of job opportunities on employee turnover intention at PT. Valbury Asia Futures Semarang. The population used in this study were all employees working at PT. Valbury Asia Futures Semarang and the sample used is 70 employees. This study used non-probability sampling technique research methods with saturated sampling method (census). Data analysis in this study used the SPSS 24 program. The data analysis technique used was multiple linear regression analysis. The results of the analysis and discussion show that the variable Compensation has a partial negative effect on Turnover Intention, Leadership Style has a partial negative effect on Turnover Intention, Work Environment has a partial negative effect on Turnover Intention, and Perception of Work Opportunities has a partial positive effect on Turnover Intention at PT. Valbury Asia Futures Semarang.
ВОПРОСЫ ОПРЕДЕЛЕНИЯ СПОРНОГО РОДСТВА У СЕЛЬСКОХОЗЯЙСТВЕННЫХ ЖИВОТНЫХ И ИХ ПРИКЛАДНОЕ ЗНАЧЕНИЕ В СУДЕБНОЙ СИСТЕМЕ
Authors: Нурбаев Серик , Бисенов Утепберген , Ирзагалиев Косыбек , Утаубаева Алма , Мамырханова Сайран
Published: July 2023

Несовершенство законодательной системы в области определения родства у сельскохозяйственных животных открывает лазейки для злоупотреблений. В полной мере это касается технического регулирования в области судебной молекулярно-генетической экспертизы, где от совершенства системы стандартизации в конечном итоге зависит юридический статус и судьба конкретных людей. В настоящее время по этой проблеме существуют лишь разрозненные и зачастую несогласованные внутриведомственные нормативные документы типа методических рекомендаций, методических указаний и инструкций, некоторые положения которых подвергаются справедливой критике. В большинстве «Методических указаниях» имеются многочисленные противоречия, неточности, неоднозначные указания, допускающие противоположные трактовки, неполные разъяснения, что недопустимо для руководства, рассматриваемого как юридический документ. Эти вопросы могут стать решающими в суде при согласии или несогласии с результатами ДНК-экспертизы. Такие недостатки способны существенно повлиять на качество судебно-генетической экспертизы и привести к назначению дополнительной или повторной экспертизы. Требования, устанавливаемые нормативными документами по стандартизации, должны основываться на современных достижениях науки, техники и технологии, международных (региональных) стандартах, правилах, нормах и рекомендациях по стандартизации, прогрессивных национальных стандартах других государств.
В этом плане трудно переоценить своевременность публикации «Международных рекомендаций к стандартам по проверке отцовства», которые подготовлены большим коллективом Комиссии по проверке отцовства при Международном обществе по судебной генетике. Заслуживает внимания основной принцип, которым руководствовалась Комиссия: за основу был взят международный стандарт ISO 17025:1999 «Общие требования к компетентности испытательных и калибровочных лабораторий». Особенность стандартов ISO состоит в том, что при применении их в специфических областях допускается введение дополнительных «указаний по применению», если только они никоим образом не изменяют смысла ни одного из параграфов исходного текста.
Исключительно важным представляется требование к профессиональной подготовке персонала лаборатории.
В Казахстане разработан и внедрен с 2019 г. Национальный стандарт  Республики Казахстан «Генетический анализ происхождения животных. Методика определения идентификации и контроля»  СТ РК 3074 -2017 [9].
Вопросы к установлению более удаленных степеней родства для сельскохозяйственных животных становятся актуальными в связи широким привлечением генетической экспертизы в уголовных и гражданско-правовых системах общества.
PEMENUHAN HAK TUMBUH KEMBANG ANAK MELALUI WEBSITE SITUMBANG.COM DI KELURAHAN MANGUNSARI
Authors: Sumanto Reni Pawestuti Ambari , Diana  , Khotijah Siti , Saputri Uci , Ramadhani Alfina Desia
Published: July 2023

Setiap anak memiliki potensi dan senantiasa perlu mendapatkan stimulasi dalam proses tumbuh kembangnya, Pemerintah telah memberikan ruang bagi anak untuk mendapatkan hak tumbuh kembang melalui Pos Pelayanan Terpadu (Posyandu). Pelaksanaan Posyandu mengalami hambatan selama pandemi berlangsung dan berdampak pada pemantauan tumbuh kembang anak oleh kader dan orang tua. Minimnya jumlah kader, kurangnya partisipasi aktif orang tua dan belum adanya media komunikasi yang efektif merupakan masalah yang dihadapi secara nyata di kelurahan Mangunsari, kota Semarang. Tujuan kegiatan pengabdian adalah adalah melakukan sosialisasi media komunikasi efektif (telehealth) berbasis website yaitu situmbang.com guna pemantauan tumbuh kembang di Posyandu Lestari 2, kelurahan Mangunsari. Metode yang digunakan dalam pengabdian meliputi perancangan website, sosialisasi website dan evaluasi. Pada tahap rancangan website situmbang pada bulan Juni – Juli Tahun 2022, selanjutnya tahap sosialisasi website pada 40 peserta yang terdiri dari kader Posyandu di kelurahan Mangunsari pada Agustus 2022. Terakhir pada tahap evaluasi, kebermanfaatan produk dilakukan dengan memberi instrumen pada seluruh peserta. Hasil kegiatan menunjukkan 78.6% peserta memberi respon positif untuk mengaplikasikan website dan 82.6% peserta menyatakan website situmbang.com bermanfaat serta sesuai dengan perkembangan zaman. Rekomendasi yang didapatkan berdasarkan sosialisasi website situmbang.com yaitu perlu dukungan pihak terkait agar kader dapat mengaplikasikan website.
PENGEMBANGAN PEMBANGKIT LISTRIK HYBRID UNTUK MEMENUHI KEBUTUHAN LISTRIK DESA CIPEUJEUH, KABUPATEN BANDUNG
Authors: Kristyadi Tarsisius , Hermanto Agus , Taufiq Eka , Nugraha Noviyanti , Arfianto Teguh , Hadiatna Febrian
Published: July 2023

Desa Cipeujeuh merupakan salah satu desa di kecamatan Pacet kabupaten Bandung yang membutuhkan listrik untuk penerangan jalan, pengelolaan kolam, dan pengelolaan air bersih. Ada potensi sumber energi yang dapat dimanfaatkan untuk menghasilkan listrik yaitu aliran air irigasi dan potensi sinar matahari. Tujuan kegiatan ini adalah memberdayakan masyarakat desa Cipeujeuh supaya dapat mengelola sumber energi terbarukan untuk keperluan masyarakat desa tersebut. Mitra kegiatan ini adalah pemerintah desa Cipeujeuh kabupaten Bandung Jawa barat. Pengabdian dilakukan dengan memberikan pendampingan dalam instalasi dan pengelolaan pembangkit listrik hybrid. Pembangkit listrik ini merupakan hasil penelitian dari dosen Itenas yaitu turbin aksial horizontal dengan head yang sangat rendah. Turbin ini dipasang untuk memanfaatkan saluran irigasi buatan yang ada di Desa Cipeujeuh bersama-sama dengan PLTS membentuk pembangkit listrik hybrid. Manfaat kegiatan ini adalah listrik yang dihasilkan dapat digunakan untuk penerangan jalan, aerasi kolam,  dan untuk menjalankan sistem air bersih. Kontribusi mitra adalah penyediaan lokasi, peralatan dan sarana untuk pembangkit listrik. Mereka berperan aktif dalam pelaksanaan kegiatan ini yaitu dalam pengoperasian dan perawatan serta proses pembangunan pembangkit listrik. Mitra melaksanakan pemasangan, pengoperasian dan perawatan berdasarkan teknologi yang ditawarkan. Hasil kegiatan pengabdian masyarakat ini adalah perangkat pembangkit listrik hybrid yang dapat dimanfaatkan untuk penerangan, kebutuhan air minum, dan aerasi kolam ikan sehingga masyarakat tidak perlu mengeluarkan biaya listrik untuk keperluan tersebut
PENDAMPINGAN PERANCANGAN DESAIN LOGO DAN PLAKAT GALERI INVESTASI EDUKASI DI SMA TRINITAS BANDUNG
Authors: Aryani Dewi Isma , Tjandra Miki , Chandrahera Yuma , Maximillian Arnold , Suhanjoyo Shirly Nathania
Published: July 2023

Perkembangan ekonomi dunia yang cukup pesat saat ini menjadikan latar belakang bagi pihak SMA Trinitas Bandung untuk mengenalkan lebih dini tentang ilmu investasi kepada para murid. SMA Trinitas Bandung bekerja sama dengan PT. Sinarmas Sekuritas dan Bursa Efek Indonesia untuk memberikan edukasi investasi dan ekonomi disesuaikan dengan porsi usia sekolah menengah supaya para siswa dapat mengenal dan siap mempelajari lebih lanjut tentang ilmu tersebut di jenjang pendidikan selanjutnya melalui pendirian galeri investasi edukasi. Dalam rangka mewujudkan hal tersebut, SMA Trinitas Bandung meminta pendampingan desain kepada program sarjana Desian Interior serta program sarjana Desain Komunikasi Visual, Fakultas Seni Rupa dan Desain, Universitas Kristen Maranatha sebagai penunjang estetika di galeri investasi edukasi. Kegiatan ini dilakukan melalui metode pendampingan melalui difusi ipteks berupa pembuatan desain logo serta plakat untuk galeri investasi edukasi di SMA Trinitas Bandung. Hasil kegiatan ini adalah hasil rekomendasi desain logo dan plakat yang didesain oleh tim pengabdi untuk dipergunakan pada Galeri Investasi Edukasi di SMA Trinitas Bandung.
PENDIRIAN KOPERASI PRODUSEN BAGI SMALL MEDIUM ENTERPRISES IN CULINARY DI KOTA SURABAYA
Authors: Utomo Sulistyo Budi , Suprihhadi Heru , Dewi Mega Arisia , Widiarma In'am
Published: July 2023

Usaha yang tidak mengalami guncangan atau bisa disebut tahan dalam menghadapi “turbulence” dalam kondisi tidak menentu dan terbukti berdasarkan pengalaman pasca pandemi Covid 19 yang penuh dengan tantangan, maka Usaha Mikro Kecil dan Menengah (UMKM) sebagai jawabannya dan bahkan memberikan kontribusi pada perekonomian nasional serta pembukaan lapangan pekerjaan. Selain itu, manfaat UMKM dapat menyiapkan produknya berkulitas untuk berdaya saing, berinovasi pada digitalisasi dan memperluas akses pasar didalam negeri serta luar negeri. Hal ini, dapat mendorong kerjasama dengan mitra atau lembaga yang mempunyai tujuan yang sama untuk mewujudkan kesejahteraan bersama dengan menggandeng Koperasi. Metode pelaksanaannya dengan cara melakukan pelatihan secara offline terkait peranan penting pendirian koperasi untuk UMKM bersama Dekopinda Kota Surabaya, kemudian untuk menindaklanjuti kegiatan tersebut dilakukan pendampingan secara menyeluruh kepada semua pelaku UMKM yang terlibat, langkah-langkah pendampingan sebagai berikut: 1) Rancangan visi misi pendirian Koperasi 2) Konsultasi dengan Ketua Dekopinda Kota Surabaya  3) Verifikasi nama koperasi 4) Pengajuan pengesahan akta pendirian Koperasi dibantu notaris. Hasil Kegiatan pengabdian kepada masyarakat bagi anggota UMKM di Kota Surabaya ini telah berjalan dengan baik. Kegiatan ini memberikan manfaat bagi para anggota UMKM dalam terealisasinya pendirian Koperasi dan meningkatkan kesejahteraan anggotanya.
Transmission Spectroscopy of the Lowest-density Gas Giant: Metals and a Potential Extended Outflow in HAT-P-67b
Authors: Bello-Arufe Aaron , Knutson Heather A. , Mendonça João M. , Zhang Michael M. , Cabot Samuel H. C. , Rathcke Alexander D. , Ulla Ana , Vissapragada Shreyas , Buchhave Lars A.
Published: July 2023

Extremely low-density exoplanets are tantalizing targets for atmospheric characterization because of their promisingly large signals in transmission spectroscopy. We present the first analysis of the atmosphere of the lowest-density gas giant currently known, HAT-P-67b. This inflated Saturn-mass exoplanet sits at the boundary between hot and ultrahot gas giants, where thermal dissociation of molecules begins to dominate atmospheric composition. We observed a transit of HAT-P-67b at high spectral resolution with CARMENES and searched for atomic and molecular species using cross-correlation and likelihood mapping. Furthermore, we explored potential atmospheric escape by targeting Hα and the metastable helium line. We detect Ca ii and Na i with significances of 13.2σ and 4.6σ, respectively. Unlike in several ultrahot Jupiters, we do not measure a day-to-night wind. The large line depths of Ca ii suggest that the upper atmosphere may be more ionized than models predict. We detect strong variability in Hα and the helium triplet during the observations. These signals suggest the possible presence of an extended planetary outflow that causes an early ingress and late egress. In the averaged transmission spectrum, we measure redshifted absorption at the ∼3.8% and ∼4.5% level in the Hα and He i triplet lines, respectively. From an isothermal Parker wind model, we derive a mass-loss rate of

M

̇

∼

10

13

g

s

−
1

and an outflow temperature of T ∼ 9900 K. However, due to the lack of a longer out-of-transit baseline in our data, additional observations are needed to rule out stellar variability as the source of the Hα and He signals.