bluuebunny/crossref_metadata_2025 huggingface dataset:
The Future of the Energy Sector and the Global Economy: Prosumer Capitalism and What Comes Next
Authors: Jakimowicz Aleksander
Published: December 2022

This paper describes the present and the future of the energy sector in relation to the dominant and constantly evolving form of the global economic system. These considerations have their starting point in transformations of the energy sector in prosumer capitalism, which has dramatically changed the picture of the global economy in recent years. Subsequently, a futuristic approach is applied to determine the role and importance of energy from renewable sources for further human development. The main objective of the paper is to explain the current situation of the energy sector in prosumer capitalism and to extrapolate these relationships for the future, considering the need to enter the path of sustainable development to eliminate the global warming processes and climate changes. A review of the existing scientific literature was applied as the research method. The historical wave concept, proposed by Toffler, was found to be highly useful because of its high potential in futurology, where it enables one to study megatrends. The Fourth Wave was linked to prosumer capitalism, and it provided the base for defining the next ones: the Fifth Wave of Computing (ecosocialism) and the Sixth Wave in the form of technological and energy communism (solar communism). It also turned out that the key to solving mankind’s energy problems lies in the global mean entropy budget. The literature review shows that founding the global energy system on solar radiation is the only known method for eliminating the anthropogenic greenhouse effect, which is the source of global warming and, consequently, of climate change. Therefore, the second law of thermodynamics provides a physical, economic, and logical justification for introducing a new and ultimate management form—solar communism—by 2050.
Nuclear Melt Glass from Experimental Field, Semipalatinsk Test Site
Authors: Vlasova Irina E. , Yapaskurt Vasily O. , Averin Alexei A. , Melnik Oleg E. , Zolotov Denis A. , Senin Roman A. , Poliakova Tatiana R. , Nevolin Iurii M. , Kalmykov Stepan N. , Shiryaev Andrey A.
Published: December 2022

Investigation of shocked materials provides unique information about behavior of substances in extreme thermodynamic conditions. Near surface nuclear tests have induced multiple transformations of affected soils. Examination of nuclear glasses and relics of entrapped minerals provides a unique database on their behavior under an intense temperature flash. In this work, several types of nuclear fallout particles from historic tests at the Semipalatinsk test site are investigated using complementary analytical methods. Distribution of radionuclides in all types of samples is highly heterogeneous; domains with high content of radionuclides are often intermixed with non-active materials. There is no general correlation between chemical composition of the glassy matrix and content of radionuclides. In aerodynamic fallout, the main fraction of radionuclides is trapped in the outer glassy shell. Relics of quartz grains are always devoid of radionuclides, while glass regions of high activity have different composition. In contrast to underground tests, iron-rich minerals are not necessarily radioactive. In most cases, the glassy matrix in anhydrous and is strongly polymerized, and the Q3 silicate groups dominate. Temperature-induced transformations of entrapped minerals are discussed. Investigation of zircon grains shows absence of a direct correlation between degree of decomposition into constituting oxides, morphology of resulting baddeleyite, and maximum experienced temperature. For the first time, temperature history of a nuclear ground glass is estimated from Zr diffusion profiles from decomposing zircon grain.
Research on the Electricity Market Clearing Model for Renewable Energy
Authors: Xu Gaoyuan , Wang Xiaojing
Published: December 2022

The development of renewable energy in China has made remarkable achievements, but the problem of renewable energy consumption has become increasingly prominent. This paper establishes a power market trading system for renewable energy, with the aim of promoting large-scale renewable energy consumption and increasing the enthusiasm of renewable energy producers and users to participate in market transactions. First, according to the power generation cost, the backup cost of renewable energy power plants and the possible quotation strategies of other renewable energy producers, a quotation model of renewable energy producers is established. In the clearing of the spot market by renewable energy producers, the independent market operator conducts the first-stage clearing of the electricity market with the goal of maximizing social welfare. After the announcement of the clearing results, the renewable energy producers that did not win the bid will revise their quotations and carry out the second stage clearing to realize the consumption of renewable energy. In this paper, the particle swarm algorithm combined with the CPLEX solver is used to solve the problem, and finally, different scenarios are analyzed through example analysis. The results show that, compared with the conventional power market trading mechanism, the energy abandonment rate of the power market trading mechanism for renewable energy proposed in this paper drops from 8.2% to 2.1%, and the profit margin of renewable energy producers increase by 6.6%. It is demonstrated that the proposed electricity market mechanism can effectively promote the consumption of renewable energy and increase the income of renewable energy producers.
A Machine Learning-Based Method for Modelling a Proprietary SO2 Removal System in the Oil and Gas Sector
Authors: Grimaccia Francesco , Montini Marco , Niccolai Alessandro , Taddei Silvia , Trimarchi Silvia
Published: December 2022

The aim of this study is to develop a model for a proprietary SO2 removal technology by using machine learning techniques and, more specifically, by exploiting the potentialities of artificial neural networks (ANNs). This technology is employed at the Eni oil and gas treatment plant in southern Italy. The amine circulating in this unit, that allows for a reduction in the SO2 concentration in the flue gases and to be compliant with the required specifications, is a proprietary solvent; thus, its composition is not publicly available. This has led to the idea of developing a machine learning (ML) algorithm for the unit description, with the objective of becoming independent from the licensor and more flexible in unit modelling. The model was developed in MatLab® by implementing ANNs and the aim was to predict three targets, namely the flow rate of SO2 that goes to the Claus unit, the emissions of SO2, and the flow rate of steam sent to the regenerator reboiler. These represent, respectively, the two physical outputs of the unit and a proxy variable of the amine quality. Three different models were developed, one for each target, that employed the Levenberg–Marquardt optimization algorithm. In addition, the ANN topology was optimized case by case. From the analysis of the results, it emerged that with a purely data-driven technique, the targets can be predicted with good accuracy. Therefore, this model can be employed to better manage the SO2 removal system, since it allows for the definition of an optimal control strategy and the maximization of the plant’s productivity by not exceeding the process constraints.
Precious Tree Pest Identification with Improved Instance Segmentation Model in Real Complex Natural Environments
Authors: Guo Ying , Gao Junjia , Wang Xuefeng , Jia Hongyan , Wang Yanan , Zeng Yi , Tian Xin , Mu Xiyun , Chen Yan , OuYang Xuan
Published: December 2022

It is crucial to accurately identify precious tree pests in a real, complex natural environment in order to monitor the growth of precious trees and provide growers with the information they need to make effective decisions. However, pest identification in real complex natural environments is confronted with several obstacles, including a lack of contrast between the pests and the background, the overlapping and occlusion of leaves, numerous variations in pest size and complexity, and a great deal of image noise. The purpose of the study was to construct a segmentation method for identifying precious tree pests in a complex natural environment. The backbone of an existing Mask region-based convolutional neural network was replaced with a Swin Transformer to improve its feature extraction capability. The experimental findings demonstrated that the suggested method successfully segmented pests in a variety of situations, including shaded, overlapped, and foliage- and branch-obscured pests. The proposed method outperformed the two competing methods, indicating that it is capable of accurately segmenting pests in a complex natural environment and provides a solution for achieving accurate segmentation of precious tree pests and long-term automatic growth monitoring.
Use of Pressurized and Airlift Bioreactors for Citric Acid Production by Yarrowia lipolytica from Crude Glycerol
Authors: Ferreira Patrícia , Lopes Marlene , Belo Isabel
Published: December 2022

Citric acid production is generally carried out in an aqueous medium in stirred tank reactors (STR), where the solubility of oxygen is low and the oxygen demand of microbial cultures is high. Thus, for this bioprocess, providing adequate oxygen mass transfer rate (OTR) from the gas phase into the aqueous culture medium is the main challenge of bioreactor selection and operation. In this study, citric acid production by Yarrowia lipolytica W29 from crude glycerol, in batch cultures, was performed in two non-conventional bioreactors normally associated with high mass transfer efficiency: a pressurized STR and an airlift bioreactor. Increased OTR was obtained by raising the total air pressure in the pressurized STR and by increasing the aeration rate in the airlift bioreactor. An improvement of 40% in maximum citric acid titer was obtained by raising the air pressure from 1 bar to 2 bar, whereas, in the airlift bioreactor, a 30% improvement was attained by increasing the aeration rate from 1 vvm to 1.5 vvm. Both bioreactor types can be successfully applied for the citric acid production process using alternative ways of improving OTR than increasing mechanical stirring power input, thus leading to important operating saving costs.
Chemical and Enzymatic Characterization of Leaves from Spanish Table Olive Cultivars
Authors: Ramírez Eva María , Brenes Manuel , Romero Concepción , Medina Eduardo
Published: December 2022

Olive leaves are generated as by-products in the olive industry and contain substances with biological properties that provide health benefits. Although these compounds have been characterized in many leaves from olive cultivars devoted to olive oil extraction, few data are available on leaves from the processing of table olives. In this study, the concentration of polyphenols, triterpenic acids, sugars and enzymatic activities (polyphenol oxidase, peroxidase, β-glucosidase and esterase) were determined in the leaves of the olive tree (Olea europaea L.) of cvs. Aloreña, Cacereña, Empeltre, Hojiblanca, Manzanilla, Verdial, Gordal and Morona. The mean total phenolic content in olive leaves reached 75.58 g/kg fresh weight, and oleuropein was the main polyphenol identified (89.7–96.5%). The main triterpenic acid identified was oleanolic acid, and the main sugar was mannitol, with mean values of 15.83 and 22.31 g/kg, respectively. However, the content of these biocompounds was influenced by the type of cultivar and the orchards of origin. The highest oleuropein content was found in the Manzanilla variety, while the Gordal had the highest triterpene and mannitol content. In particular, the phenolic content could also be affected by endogenous enzymatic activities. High polyphenol oxidase, peroxidase and β-glucosidase activity and low esterase activity were detected, compared to the fruit. Similar to the phenolic compounds, enzymatic activities varied with the harvesting season. The lowest phenolic content corresponded to the highest polyphenol oxidase activity detected during spring. The rest of the enzymatic activities also varied throughout the year, but no common trend was observed.
Comparative Peptidomics Analysis of Milk Fermented by Lactobacillus helveticus
Authors: Gao Shuman , Jiang Yang , Zhang Xinyi , Cui Shumao , Liu Xiaoming , Zhao Jianxin , Zhang Hao , Chen Wei
Published: December 2022

Lactobacillus helveticus is one of the commonly used starter cultures for manufacturing various fermented dairy products. However, only a few studies have explored the cleavage region preference of L. helveticus with different cell envelope proteinase (CEP) genes. In the present study, we profiled the peptide composition of milk samples fermented by three different L. helveticus strains by means of peptidomics to illustrate their different proteolysis patterns. The result revealed that the differences in peptide profiles of milk samples fermented by different L. helveticus strains were mainly a result of variations in the peptide patterns of the casein fractions, which were correlated with CEP genotypes. This was mainly reflected in the extensiveness of the hydrolysis region of αS1-casein and the degree of β-casein hydrolysis. Bioactive peptides were mostly derived from the hydrolysis region common to the three L. helveticus strains, and DQHXN-Q32M42 fermentation resulted in the highest diversity and abundance of bioactive peptides and a significant antihypertensive effect in spontaneous hypertension rats.
Prediction of Apple Hybrid Offspring Aroma Based on Hyperspectral
Authors: Zhu Huili , Wang Minyan , Zhang Jing , Ma Fengwang
Published: December 2022

Used Random forest algorithm to construct a prediction model of aroma components based on the hybrid offspring of ‘Honeycrisp’ × ‘Maodi’, and different preprocessing methods were tried (Standardization (SS), First-order Derivative (D1) and Standard normal variate (SNV)). The aroma composition and content were determined by gas chromatography-mass spectrometry (GC-MS), and the main aroma components of apples were classified according to compound categories, including ester, aldehyde, ketone, alcohol. Taking the chemical groups as the research objects, the characteristic wavelengths were selected by grid search algorithm, and the characteristic wavelength-aroma chemical group model was established, and the same method was used to construct the model for single aroma components. The results show: SNV has the best noise removal effect among the five preprocessing methods. Under the SNV treatment, aroma chemical groups of apples showed a good correlation with the spectrum. The number of characteristic spectra of ester are 413, 493, 512, 551, 592, 600, 721, 727, 729, 733 nm, all in the visible light range. The determination coefficient (R2), the root mean square error (RMSE) and the ratio of the standard deviation values (RPD) of validation were 0.90, 4936.16 and 1.13. The characteristic spectrum of alcohols is 519, 562, 570, 571, 660, 676, 737, 738 nm, the range is close to that of ester. The R2 and RMSE of alcohol validation are 0.92 and 83.21, and RPD is 1.30. The number of characteristic spectra of aldehyde is 20, and the most important band is 1000 nm, which is outside the visible light range. The number of characteristic spectra of ketone is 15, and also has some distribution outside the visible light range. The R2 of aldehyde and ketone validation are 0.84 and 0.86. Except for cyclooctanol, the R2 of single aroma compound prediction model performed poorly. Based on the models, we tried to visualize alcohol, which can roughly represent their distribution on apple. Their distributions all show significant differences in the center and edge of apple, but the results are still rough due to the accuracy of models. In conclusion, the study can preliminarily prove that hyperspectral imaging technology (HSI) can perform non-destructive detection of aroma in apple hybrid offspring.
Local-Level Flood Hazard Management in Canada: An Assessment of Institutional Structure and Community Engagement in the Red River Valley of Manitoba
Authors: Zaman Jobaed Ragib , Haque C. Emdad , Walker David
Published: December 2022

While there is a large body of literature focusing on global-level flood hazard management, including preparedness, response, and recovery, there is a lack of research examining the patterns and dynamics of community-level flood management with a focus on local engagement and institutional mechanism. The present research explores how local communities mobilize themselves, both individually and institutionally, to respond to emerging flood-related situations and recover from their impacts. A case study approach was applied to investigate two towns in the Red River Valley of Manitoba, Canada: St. Adolphe and Ste. Agathe. Data collection consisted of in-depth interviews and oral histories provided by local residents, in addition to analysis of secondary official records and documents. The findings revealed that local community-level flood preparedness, response, and recovery in the Province of Manitoba are primarily designed, governed, managed, and evaluated by the provincial government authorities using a top-down approach. The non-participatory nature of this approach makes community members reluctant to engage with precautionary and response measures, which in turn results in undesired losses and damages. It is recommended that the Government of Manitoba develop and implement a collaborative and participatory community-level flood management approach that draws upon the accumulated experiential knowledge of local stakeholders and institutions.
Comparison of Jaw Mode and Field Width for Left-Breast Cancer Using TomoDirect Three-Dimensional Conformal Radiation Therapy: A Phantom Study
Authors: Kim Haneul , Jung Jaehong , Jung Hyunseo , Jeong Jibeom , Lee Dohwa , Jeong Hyun-Woo , Lee Youngjin
Published: December 2022

It is very important to use effective parameters in the treatment plan of breast cancer patients in TomoDirect (TD)-three-dimensional conformal radiation therapy (TD-3DCRT). The objective of this study was to compare the radiation treatment plans to the parameters (jaw width and jaw mode) of TD-3DCRT for left-breast cancer. This study was conducted using the phantom, the jaw mode (fixed and dynamic) and field width (2.5 cm and 5.0 cm) were controlled to compare the TD-3DCRT treatment plans. There was small difference in the conformity index (CI) and homogeneity index (HI) values for target according to the jaw mode for each field width. As a result of observation in terms of dose, treatment time and unnecessary damage to surrounding normal organs could be minimized when dynamic jaw with a field width of 5.0 cm was used. In conclusion, we verified that the use of dynamic jaws and 5.0 cm field width was effective in left-breast cancer radiotherapy plan using TD-3DCRT.
Medich Giant Platelet Syndrome: An Evolving Qualitative and Quantitative Platelet Disorder
Authors: Massey Gita , Tyrrell Laura , Diab Yaser , Gunning William T.
Published: December 2022

Qualitative platelet disorders remain rare and varied. We describe here 2 additional patients with giant platelets, thrombocytopenia, deficiency in alpha granules and the presence of membranous inclusions within the cytoplasm. Collectively known as Medich syndrome, we further elucidated structural and clinical features of this rare syndrome. Platelets obtained from 2 patients with macro-thrombocytopenia were evaluated by electron microscopy. Structural findings were correlated with clinical characteristics. The defining morphologic feature found in the platelets of these patients is the presence of long, tubular inclusions consisting of several layers of membrane wrapped around a core of cytoplasm. These inclusions may deform the discoid shape of the platelet. In addition, abnormal giant alpha granules are present. Clinically all patients in the current report and review of the literature had mucosal bleeding and were often misdiagnosed as having immune related thrombocytopenia. To date five cases of Medich giant platelet syndrome have been reported. The cases are unified by the ultrastructural findings of abnormal alpha granules and unusual cytoplasmic scrolls. All patients experienced mucosal bleeding, however many clinical, biologic and genetic characteristics of this rare disorder remain to be determined.
A Novel Application of Risk–Risk Tradeoffs in Occupational Health: Nurses’ Occupational Asthma and Infection Risk Perceptions Related to Cleaning and Disinfection during COVID-19
Authors: Wilson Amanda M. , Mussio Irene , Chilton Susan , Gerald Lynn B. , Jones Rachael M. , Drews Frank A. , LaKind Judy S. , Beamer Paloma I.
Published: December 2022

Background: Nurses face the risk of new onset occupational asthma (OA) due to exposures to cleaning and disinfection (C&D) agents used to prevent infections in healthcare facilities. The objective of this study was to measure nurses’ preferences when presented with simultaneous OA and respiratory viral infection (e.g., COVID-19) risks related to increased/decreased C&D activities. Methods: Nurses working in healthcare for ≥1 year and without physician-diagnosed asthma were recruited for an online anonymous survey, including four risk–risk tradeoff scenarios between OA and respiratory infection with subsequent recovery (Infect and Recovery) or subsequent death (Infect and Death). Nurses were presented with baseline risks at hypothetical “Hospital 1”, and were asked to choose Hospital 2 (increased OA risk to maintain infection risk), Hospital 3 (increased infection risk to maintain OA risk), or indicate that they were equally happy. Results: Over 70% of nurses were willing to increase infection risk to maintain baseline OA risk if they were confident they would recover from the infection. However, even when the risk of infection leading to death was much lower than OA, most nurses were not willing to accept a larger (but still small) risk of death to avoid doubling their OA risk. Age, work experience, and ever having contracted or knowing anyone who has contracted a respiratory viral infection at work influenced choices. Conclusions: We demonstrate the novel application of a risk–risk tradeoff framework to address an occupational health issue. However, more data are needed to test the generalizability of the risk preferences found in this specific risk–risk tradeoff context.
Spatial-Temporal Patterns of Ecosystem Services Supply-Demand and Influencing Factors: A Case Study of Resource-Based Cities in the Yellow River Basin, China
Authors: Ming Li , Chang Jiang , Li Cheng , Chen Yedong , Li Cankun
Published: December 2022

The aim of this study was to reveal the spatiotemporal pattern of the supply and demand of ecosystem services (ESs), as well as the significant driving factors for understanding the impact of human activities on the natural ecosystem. To provide a scientific basis for formulating regional sustainable development strategies that enhance human well-being, resource-based cities in the Yellow River Basin (YRB) were selected as the case study. The supply and demand of ecosystem services in these cities from 2000 to 2020 were measured. The spatiotemporal evolution of the supply-demand relationship was illustrated by taking its coordination degree. In addition, geographical detector and geographically weighted regression (GWR) models were applied to quantify the spatiotemporally varying effects of natural and socioeconomic factors on the ES supply--demand relationship. The results showed that resource-based cities in the YRB were experiencing expansion in supply and demand overall, but the supply-demand relationship tended to be tense. The northwest YRB had higher coordination values of supply-demand, while lower values were found in the southeast YRB. Moreover, the relationship between supply and demand was significantly affected by natural and socioeconomic factors, such as elevation, slope, precipitation, land-use type, population density, and gross domestic product (GDP) per land. Furthermore, the GWR model suggested that the effects of driving factors on the supply-demand relationship had notable spatial heterogeneity. The coordination of ES supply-demand in the resource-based cities of southeast YRB was mainly influenced by socioeconomic factors, while that of the west YRB was mainly influenced by natural factors. Our study suggested that it is necessary to enhance the awareness of environmental protection, pay attention to ecological restoration, and avoid unreasonable human disturbance to the ecosystem.
Mindfulness on Rumination in Patients with Depressive Disorder: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Li Pan , Mao Lingyun , Hu Maorong , Lu Zihang , Yuan Xin , Zhang Yanyan , Hu Zhizhong
Published: December 2022

Objective: To systematically evaluate the effectiveness of mindfulness-based interventions (MBIs) on rumination among patients with depression and their efficacy across countries and year of publication and control conditions. Methods: Web of Science Core Collection, Medline, BIOSIS Citation Index, KCI-Korean Journal Database, SciELO Citation Index, PubMed, Cochrane Library, and Embase were searched to include randomized controlled trials of MBIs for depressive rumination that met the criteria. The Rumination Scale was used as the primary outcome indicator; Depression, mindfulness, and anxiety indexes were selected as the secondary outcome indicators. An evaluation of bias risk was conducted to identify possible sources of bias based on methodological and clinical factors. RevMan5.3 software was used to perform a meta-analysis of the extracted data. Results: Nineteen studies with 1138 patients were included. Meta-analysis showed that MBIs could significantly reduce rumination levels in patients with depression (standardized mean difference (SMD) = −0.46; 95% confidence interval (CI): −0.58, −0.34; p < 0.001), notably improve depression (SMD = −0.58; 95% CI: −0.83, −0.32; p < 0.001), enhance mindfulness ability (SMD = 0.95; 95% CI: 0.57, 1.32; p < 0.001), and reduce the anxiety of patients with depression (SMD = −0.45, 95% CI: −0.62, −0.27; p < 0.001). MBIs conducted in Asia improved rumination better than studies in Europe and North America (SMD = −2.05 95% CI: −4.08, −0.01; p < 0.001) but had no greater effect than behavior activation on depression. The interventions carried out in the past 5 years were significantly better than earlier studies in improving mindfulness levels (SMD = 2.74; 95% CI: 0.81, 4.66; p = 0.005). Conclusions: MBIs are effective in the treatment of depression as they produce pleasant improvement in rumination and depression, decrease the degree of anxiety, and enhance mindfulness levels compared to controls. In newer forms of MBIs, regional differences need to be considered when designing the intervention program. More large, high-quality randomized controlled studies are needed to confirm the conclusion that the effectiveness of MBIs has differences in terms of the trial area and year of publication.
Exploring the Relationship between Ecosystem Services under Different Socio-Economic Driving Degrees
Authors: Ma Tiantian , Hu Qingbai , Wang Changle , Lv Jungang , Mi Changhong , Shi Rongguang , Wang Xiaoli , Yang Yanying , Wu Wenhao
Published: December 2022

The large-scale transformation of natural ecosystems to socio-economic development land types under human activities was a primary reason for the decline of regional ecosystem services. It is a key issue for regional ecosystem planning and management to reveal the relationship between ecosystem services of different land use types under different socio-economic driving degrees. However, the current related research was not in-depth. Based on the land use data of Wuhan City in 1980, 1990, 2000, 2010, and 2020, this study classified land use into three categories according to the different degrees of human activities on natural ecosystem development: the land use of a natural ecosystem (LUNE), the land use of a productive ecosystem (LUPE), and the land use of a socio-economic system (LUSE). The InVEST model was used to simulate five ecosystem services (grain yield, water yield, carbon storage, habitat quality, and water purification), and the spatio-temporal distribution and functional transformation of the three land use types were analyzed. Results showed that with the intensified urban expansion in Wuhan, the LUSE types increased to 2.7 times that of the original. However, the natural land types basically maintained a stable area, coupling with the large-scale transformation between the LUPE and LUSE types. Land use change resulted in significant spatial changes of five ecosystem services, especially carbon storage and habitat quality. The correlation analysis indicated that the five kinds of ecosystem services mainly showed a synergistic relationship, meanwhile the LUSE type denoted the most significant correlation with ecosystem services among these three category types. This study indicated that besides the protection of natural ecosystems, the LUSE type would become the key land use type in the planning and management of improving regional ecological function.
Effect of Whole-Body Vibration on Serum Levels of Brain Derived Neurotrophic Factor and Cortisol in Young, Healthy Women
Authors: Piotrowska Anna , Gattner Halina , Adamiak Justyna , Mętel Sylwia , Czerwińska-Ledwig Olga , Pilch Wanda , Sadowska-Krępa Ewa , Żychowska Małgorzata , Uher Ivan , Pałka Tomasz
Published: December 2022

Vibration exercises on a platform (whole-body vibration, WBV), widely used in rehabilitation, sports medicine, and fitness, is an alternative to strength effort. The presented study assessed the effect of a 12-week cycle of vibration training on the serum concentrations of brain-derived neurotrophic factor (BDNF) and cortisol in young women (trial ID: ACTRN 12621000114842). Volunteers were assigned to three groups: performing exercises on a vibrating platform (n = 17), performing identical exercises without a platform (n = 12), and passive control group (n = 17). The concentration of BDNF and cortisol was assessed four times: before the first training session, 5 min after it, also before, and 5 min after the last training session. There were no statistically significant changes in the groups or among groups for both substances. WBV in the presented form did not increase the secretion of BDNF and is not a stressful stimulus.
How to Improve the Care of Women after Childbirth in the Rooming-in Unit: A Prospective Observational Study
Authors: Prokopowicz Anna , Stańczykiewicz Bartłomiej , Uchmanowicz Izabella , Zimmer Mariusz
Published: December 2022

Rooming-in is the WHO-recommended care system for mothers in the puerperium and their babies. This system allows the newborn to stay with the mother in the same room, 24 h a day. We aimed to investigate the need to entrust a newborn (NEN) in the care of maternity rooming-in staff during the COVID-19 pandemic, and its relationship to pain, anxiety, and blood loss after delivery. A prospective study of 200 adult women in the maternity ward operating in the rooming-in system focussed on NEN in the care of maternity rooming-in staff on the first (T1) and the second day of puerperium (T2). Women who declared having NEN were compared with women without NEN for anxiety, pain, and a drop in haemoglobin in the blood after delivery. In T1, 34% and in T2, 27% of women felt NEN in the care of maternity rooming-in staff. The NEN of women after a cesarean section was higher on both days than the NEN of women after vaginal delivery. Women with NEN had higher levels of pain, state anxiety, and higher levels of postpartum anxiety than women without NEN. Further research should be warranted to investigate whether women who give birth in hospitals that satisfy the NEN in the care of maternity rooming-in staff in their rooming-in units experience less pain and anxiety in comparison to those who give birth in hospital units without such a possibility and whether this factor is an important element in reducing anxiety and pain during puerperium.
Stress, Coping and Considerations of Leaving the Profession—A Cross-Sectional Online Survey of Teachers and School Principals after Two Years of the Pandemic
Authors: Lücker Petra , Kästner Anika , Hannich Arne , Schmeyers Lena , Lücker Janny , Hoffmann Wolfgang
Published: December 2022

Teaching is amongst the six professions with the highest stress levels and lowest job satisfaction, leading to a high turnover rate and teacher shortages. During the pandemic, teachers and school principals were confronted with new regulations and teaching methods. This study aims to examine post-pandemic stress levels, as well as resilience factors to proactively cope with stress and thoughts of leaving the profession among teachers and school principals. We used a cross-sectional online survey. The validated instruments Perceived Stress Scale (PSS-10) and Proactive Coping Subscale (PCI) were used. We included 471 teachers and 113 school principals in the analysis. Overall, respondents had a moderate stress level. During the pandemic, every fourth teacher (27.2%) and every third principal (32.7%) had serious thoughts of leaving the profession. More perceived helplessness (OR = 1.2, p < 0.001), less self-efficacy (OR = 0.8, p = 0.002), and poorer coping skills (OR = 0.96, p = 0.044) were associated with a higher likelihood of thoughts of leaving the profession for teachers, whereas for school principals, only higher perceived helplessness (OR = 1.2, p = 0.008) contributed significantly. To prevent further teacher attrition, teachers and school principals need support to decrease stress and increase their ability to cope.
The Mediating Effect of Functional Health on the Relationship between Social Capital and Cognition among Chinese Older Adults
Authors: Liu Xinyu , Wang Shuangshuang , Liu Siqi , Yao Nengliang , Wang Quan , Sun Xiaojie
Published: December 2022

This study evaluated the association between cognition and social capital among Chinese older adults and analyzed the mediating role of functional health in that interaction. The baseline and follow-up data were acquired from the 2011 and 2015 China Health and Retirement Longitudinal Study (CHARLS). The sample included 6291 adults aged 55 years and above in 2011. The dimensions of social capital included social trust, social support, social participation, and reciprocity. Cognition was measured based on mental state and episodic memory. The Karlson–Holm–Breen method was employed to explore the association between social capital at the baseline and cognition four years later, and the mediating role of baseline functional health. There was a positive relationship between financial support (one of the social support variables) and reciprocity, and mental state (β = 0.186, p = 0.00; β = 0.306, p = 0.012). Furthermore, a positive relationship between social participation and episodic memory (β = 0.129, p = 0.002) was observed. The mediating effect of functional health explained 7.7% of the total effect of social participation on episodic memory. These findings may contribute to research concerning the potential explanation of the association between social capital and cognition as well as interventions aimed at improving cognitive performance in older adults.
Factors Associated with Self-Reported Post/Long-COVID—A Real-World Data Study
Authors: Thronicke Anja , Hinse Maximilian , Weinert Stefanie , Jakubowski Alexandra , Grieb Gerrit , Matthes Harald
Published: December 2022

Evidence suggests that Post/Long-COVID (PLC) is associated with a reduced health-related quality of life, however little knowledge exists on the risk factors that contribute to PLC. The objective of this prospective real-world data study was to evaluate factors associated with PLC using national online survey data. Adjusted multivariable regression analyses were performed using the software R. Between 14 April and 15 June 2021, 99 registered individuals reported to have suffered from PLC symptoms and the most common PLC symptoms reported were fatigue, dyspnoea, decreased strength, hyposmia, and memory loss. The odds of individuals suffering from COVID-19-associated anxiety, hyposmia, or heart palpitations developing PLC were eight times (OR 8.28, 95% CI 1.43–47.85, p < 0.01), five times (OR 4.74, 95% CI 1.59–14.12, p < 0.005), or three times (OR 2.62, 95% CI 1.72–3.99, p < 0.01) higher, respectively, than of those who had not experienced these symptoms. Individuals who experienced fatigue while having COVID-19 were seven times more likely to develop PLC fatigue than those who had not (OR 6.52, 95% CI: 4.29–9.91, p < 0.0001). Our findings revealed that 13% of the individuals who had previously suffered from COVID-19 subsequently reported having PLC. Furthermore, COVID-19-associated anxiety, hyposmia, heart palpitations, and fatigue were, among others, significant determinants for the development of PLC symptoms. Hyposmia has not previously been reported as an independent predictive factor for PLC. We suggest closely monitoring patients with COVID-19-induced fatigue, heart palpitations, and anxiety, as these symptoms may be predictors of PLC symptoms, including fatigue.
Water Quality Criteria and Ecological Risk Assessment of Typical Transition Metals in South Asia
Authors: Wang Ying , Rume Tanjena , Islam S. M. Didar-Ul , Fan Wenhong , Wu Jiangyue , Li Xiaomin
Published: December 2022

Transition metal pollution in rivers in South Asia is more serious than in other regions because of the lack of adequate freshwater management measures. Water quality criteria (WQC) for South Asia is urgently needed to protect regional aquatic environments because of the occurrence of transboundary rivers. The present study established non-parametric kernel density estimation species sensitivity distribution (NPKDE-SSD) models and then derived the acceptable hazardous concentration for protection of 95% of all aquatic species (HC5) and WQC of six typical transition metals in South Asia. The results showed that the order of acute and chronic WQC was Mn > Fe > Cd > Zn > Cu > Hg and Cu > Fe > Cd, respectively. A risk assessment of these metals in the Indus River, the Ganges River, the Brahmaputra River, the Meghna River, and the Bagmati River was also carried out. Based on the results, these major rivers in South Asia were highly polluted with transition metals, with significant ecological risks for a large number of aquatic species. This study can contribute to a better understanding of ecological risks in South Asia and provide a scientific basis for the updating of water quality standards and the increase in overall water quality.
Exploring Health Care Professionals’ Perceptions Regarding Shared Clinical Decision-Making in Both Acute and Palliative Cancer Care
Authors: Ullgren Helena , Sharp Lena , Fransson Per , Bergkvist Karin
Published: December 2022

Developments in cancer care have resulted in improved survival and quality of life. Integration of acute and palliative cancer care is desirable, but not always achieved. Fragmented care is associated with sub-optimal communication and collaboration, resulting in unnecessary care transitions. The aim of this study was to explore how health care professionals, from both acute and palliative care, perceive clinical decision-making when caring for patients undergoing active cancer treatment in parallel with specialized palliative care at home. Methods: Qualitative explorative design, using online focus-group interviews, based on patient-cases, among health care professionals (physicians and nurses) and Framework Analysis. Results: Six online focus-group interviews were performed. Few signs of systematic integration were found, risking fragmented care, and putting the patients in a vulnerable situation. Different aspects of uncertainty related to mandates and goals-of-care impacted clinical decision-making. Organizational factors appeared to hinder mutual clinical decision-making as well as the uncertainty related to responsibilities. These uncertainties seemed to be a barrier to timely end-of-life conversations and clinical decisions on optimal care, for example, the appropriateness of transfer to acute care. Conclusions: Lack of integration between acute and palliative care have negative consequences for patients (fragmented care), health care professionals (ethical stress), and the health care system (inadequate use of resources).
Progress in Anticancer Drug Development Targeting Ubiquitination-Related Factors
Authors: Li Qianqian , Zhang Weiwei
Published: December 2022

Ubiquitination is extensively involved in critical signaling pathways through monitoring protein stability, subcellular localization, and activity. Dysregulation of this process results in severe diseases including malignant cancers. To develop drugs targeting ubiquitination-related factors is a hotspot in research to realize better therapy of human diseases. Ubiquitination comprises three successive reactions mediated by Ub-activating enzyme E1, Ub-conjugating enzyme E2, and Ub ligase E3. As expected, multiple ubiquitination enzymes have been highlighted as targets for anticancer drug development due to their dominant effect on tumorigenesis and cancer progression. In this review, we discuss recent progresses in anticancer drug development targeting enzymatic machinery components.
Replacing the Burden of the Gluten Free Diet: Then, Now, and the Future
Authors: Nemteanu Roxana , Ciortescu Irina , Hincu Corina Elena , Clim Andreea , Gheorghe Liliana , Trifan Anca , Plesa Alina
Published: December 2022

Without a doubt, a majority of diseases are food-pattern-related. However, one disease stands out as an increasingly more common autoimmune-mediated enteropathy triggered by the ingestion of gluten. Celiac disease (CD) is an old disease, with changing clinical patterns, affecting any age, including infancy and adolescence, and becoming more frequent among the elderly. The gluten-free diet (GFD) has been the sole provider of clinical, serological, and histological improvement for patients with CD for more than seven decades. Nowadays, complete avoidance of dietary gluten is rarely possible because of the wide availability of wheat and other processed foods that contain even more gluten, to the detriment of gluten-free products. Undeniably, there is a definite need for replacing the burdensome GFD. An add-on therapy that could control the dietary transgressions and inadvertent gluten consumption that can possibly lead to overt CD should be considered while on GFD. Nevertheless, future drugs should be able to provide patients some freedom to self-manage CD and increase food independence, while actively reducing exposure and mucosal damage and alleviating GI symptoms. Numerous clinical trials assessing different molecules have already been performed with favorable outcomes, and hopefully they will soon be available for patient use.
Natural-Product-Mediated Autophagy in the Treatment of Various Liver Diseases
Authors: Fan Guifang , Li Fanghong , Wang Ping , Jin Xuejing , Liu Runping
Published: December 2022

Autophagy is essential for the maintenance of hepatic homeostasis, and autophagic malfunction has been linked to the pathogenesis of substantial liver diseases. As a popular source of drug discovery, natural products have been used for centuries to effectively prevent the progression of various liver diseases. Emerging evidence has suggested that autophagy regulation is a critical mechanism underlying the therapeutic effects of these natural products. In this review, relevant studies are retrieved from scientific databases published between 2011 and 2022, and a novel scoring system was established to critically evaluate the completeness and scientific significance of the reviewed literature. We observed that numerous natural products were suggested to regulate autophagic flux. Depending on the therapeutic or pathogenic role autophagy plays in different liver diseases, autophagy-regulative natural products exhibit different therapeutic effects. According to our novel scoring system, in a considerable amount of the involved studies, convincing and reasonable evidence to elucidate the regulatory effects and underlying mechanisms of natural-product-mediated autophagy regulation was missing and needed further illustration. We highlight that autophagy-regulative natural products are valuable drug candidates with promising prospects for the treatment of liver diseases and deserve more attention in the future.
Mlig-SKP1 Gene Is Required for Spermatogenesis in the Flatworm Macrostomum lignano
Authors: Biryukov Mikhail , Dmitrieva Anastasia , Vavilova Valeriya , Ustyantsev Kirill , Bazarova Erzhena , Sukhikh Igor , Berezikov Eugene , Blinov Alexandr
Published: December 2022

In a free-living flatworm, Macrostomum lignano, an S-phase kinase-associated protein 1 (SKP1) homologous gene was identified as enriched in proliferating cells, suggesting that it can function in the regulation of stem cells or germline cells since these are the only two types of proliferating cells in flatworms. SKP1 is a conserved protein that plays a role in ubiquitination processes as a part of the Skp1-Cullin 1-F-box (SCF) ubiquitin ligase complex. However, the exact role of Mlig-SKP1 in M. lignano was not established. Here, we demonstrate that Mlig-SKP1 is neither involved in stem cell regulation during homeostasis, nor in regeneration, but is required for spermatogenesis. Mlig-SKP1(RNAi) animals have increased testes size and decreased fertility as a result of the aberrant maturation of sperm cells. Our findings reinforce the role of ubiquitination pathways in germ cell regulation and demonstrate the conserved role of SKP1 in spermatogenesis.
Interactions between Major Bioactive Polyphenols of Sugarcane Top: Effects on Human Neural Stem Cell Differentiation and Astrocytic Maturation
Authors: Iwata Kengo , Ferdousi Farhana , Arai Yoshinobu , Isoda Hiroko
Published: December 2022

Sugarcane (Saccharum officinarum L.) is a tropical plant grown for sugar production. We recently showed that sugarcane top (ST) ameliorates cognitive decline in a mouse model of accelerated aging via promoting neuronal differentiation and neuronal energy metabolism and extending the length of the astrocytic process in vitro. Since the crude extract consists of multicomponent mixtures, it is crucial to identify bioactive compounds of interest and the affected molecular targets. In the present study, we investigated the bioactivities of major polyphenols of ST, namely 3-O-caffeoylquinic acid (3CQA), 5-O-caffeoylquinic acid (5CQA), 3-O-feruloylquinic acid (3FQA), and Isoorientin (ISO), in human fetal neural stem cells (hNSCs)- an in vitro model system for studying neural development. We found that multiple polyphenols of ST contributed synergistically to stimulate neuronal differentiation of hNSCs and induce mitochondrial activity in immature astrocytes. Mono-CQAs (3CQA and 5CQA) regulated the expression of cyclins related to G1 cell cycle arrest, whereas ISO regulated basic helix-loop-helix transcription factors related to cell fate determination. Additionally, mono-CQAs activated p38 and ISO inactivated GSK3β. In hNSC-derived immature astrocytes, the compounds upregulated mRNA expression of PGC-1α, a master regulator of astrocytic mitochondrial biogenesis. Altogether, our findings suggest that synergistic interactions between major polyphenols of ST contribute to its potential for neuronal differentiation and astrocytic maturation.