bluuebunny/crossref_metadata_2025 huggingface dataset:
Adipose-derived stem cells promote the recovery of intestinal barrier function by inhibiting the p38 MAPK signaling pathway
Authors: Yang Mei , Xu Wangbin , Yue Chaofu , Li Rong , Huang Xian , Yan Yongjun , Yan Qinyong , Liu Shisheng , Liu Yuan , Li Qiaolin
Published: January 2025

Intestinal barrier damage causes an imbalance in the intestinal flora and microbial environment, promoting a variety of gastrointestinal diseases. This study aimed to explore the mechanism by which adipose-derived stem cells (ADSCs) repair intestinal barrier damage. The human colon adenocarcinoma cell line Caco-2 and rats were treated with lipopolysaccharide (LPS) to establish in vitro and in vivo models, respectively, of intestinal barrier damage. The expression of inflammatory cytokines (TNF-α, HMGB1, IL-1β and IL-6), antioxidant enzymes (iNOS, SOD and CAT), and oxidative products (MDA and 8-iso-PGF2α) was detected using ELISA kits and related reagent kits. Apoptosis-related proteins (Bcl-2, Bax, Caspase-3 and Caspase-9), tight junction proteins (ZO-1, Occludin, E-cadherin, and Claudin-1) and p38 MAPK pathway-associated protein were detected by Western blotting. In addition, cell viability and apoptosis was determined by a CCK-8 kit and flow cytometry, respectively. Cell permeability was assayed by the transepithelial electrical resistance value and FITC-dextran concentration. The homing effect of ADSCs was detected by fluorescence labeling, and intestinal barrier tissue was observed by HE staining. After ADSC treatment, the level of phosphorylated p38 MAPK protein decreased, the expression of inflammatory factors, oxidative stress and cell apoptosis decreased, the expression of tight junction proteins increased, and cell permeability decreased in Caco-2 cells stimulated with LPS. In rats, ADSCs are directionally recruited to damaged intestinal tissue. ADSCs significantly decreased the levels of D-lactate, diamine oxidase (DAO) and FITC-dextran induced by LPS. ADSCs promoted tight junction proteins and inhibited oxidative stress in intestinal tissue. These effects were reversed after the use of a p38 MAPK activator. ADSCs can be directionally recruited to intestinal tissue, upregulate tight junction proteins, and reduce apoptosis and oxidative stress by inhibiting the p38MAPK signaling pathway. This study provides novel insights into the treatment of intestinal injury.
Erratum - Effect of Danggui Buxue decoction on hypoxia-induced injury of retinal Müller cells in vitro
Authors: Ge Xilin , Huang Caoxin , Chen Wenting , Yang Chen , Huang Wenfang , Li Jia , Yang Shuyu
Published: January 2025

This corrects the article published in European Journal of Histochemistry 2024;68:4140 doi: 10.4081/ejh.2024.4140 IF: 2.1 Q4 B4 IF: 2.1 Q4 B4
Rare Case of Acinetobacter Endocarditis in a Native Valve Patient
Authors: Kulkarni Srihari Gururaj , Kulkarni Suraj Kumar
Published: January 2025

We report a case of a 30-year-old male with a history of alcohol consumption and intravenous drug abuse who presented with exertional breathlessness for a year. On admission, he developed chest pain and right-sided weakness. Imaging revealed a right internal capsule infarct, suggestive of an embolic stroke. Two-dimensional echocardiography showed mitral valve vegetations and features of rheumatic heart disease (RHD). Blood cultures grew Acinetobacter spp., a rare pathogen for native valve endocarditis (NVE). The patient was treated with meropenem and amikacin for 6 weeks, along with anticoagulation and supportive care. He improved symptomatically and was discharged after repeat blood cultures were negative. This case illustrates that while Acinetobacter is an uncommon cause of NVE, it should be considered, particularly in patients with significant risk factors such as intravenous drug abuse and RHD.
Arbitrarily large veering triangulations with a vanishing taut polynomial
Authors: Parlak Anna
Published: January 2025

Landry, Minsky, and Taylor introduced an invariant of veering triangulations called the taut polynomial. Via a connection between veering triangulations and pseudo-Anosov flows, it generalizes the Teichmüller polynomial of a fibered face of the Thurston norm ball to (some) non-fibered faces. We construct a sequence of veering triangulations, with the number of tetrahedra tending to infinity, whose taut polynomials vanish. The conclusion is that the size of a veering triangulation does not correlate with the ‘complexity’ of its taut polynomial. Furthermore, our result shows that the taut polynomials of veering triangulations representing non-fibered faces of the Thurston norm ball behave differently than the Teichmüller polynomials.
Asymptotic one-dimensional symmetry for the Fisher–KPP equation
Authors: Hamel François , Rossi Luca
Published: January 2025

Let

u

be a solution of the Fisher–KPP equation

\partial_{t} u=\Delta u+f(u)

,

t>0

,

x\in\mathbb{R}^{N}

, with an initial datum

u_{0}

. We address the following question: does 

u

become locally planar as

t\to+\infty

? Namely, does 

u(t_{n},x_{n}+\cdot)

converge locally uniformly, up to subsequences, towards a one-dimensional function, for any sequence

((t_{n},x_{n}))_{n\in\mathbb{N}}

in

(0,+\infty)\times\mathbb{R}^{N}

such that

t_{n}\to+\infty

as

n\to+\infty

? This question is in the spirit of the celebrated De Giorgi’s conjecture concerning stationary solutions of the Allen–Cahn equation. Some affirmative answers to the above question are known in the literature: when the support of the initial datum 

u_{0}

is bounded or when it lies between two parallel half-spaces. Instead, the answer is negative when the support of 

u_{0}

is “V-shaped”. We prove here that

u

is asymptotically locally planar when the support of 

u_{0}

is a convex set (satisfying in addition a uniform interior ball condition), or, more generally, when it is at finite Hausdorff distance from a convex set. We actually derive the result under an even more general geometric hypothesis on the support of 

u_{0}

. We recover in particular the aforementioned results known in the literature. We further characterize the set of directions in which 

u

is asymptotically locally planar, and we show that the asymptotic profiles are monotone. Our results apply in particular when the support of 

u_{0}

is the subgraph of a function with vanishing global mean.
Balanced switchable bandpass filter with differential‐mode reflectionless characteristics
Authors: Wang Zicheng , Wang Zhongbao , Liu Hongmei , Fang Shaojun
Published: January 2025

This paper presents a balanced switchable bandpass filter (SBPF) with differential‐mode (DM) reflectionless characteristics in the on‐state. The proposed SBPF consists primarily of dual‐mode resonators loaded with p‐type–intrinsic–n‐type diodes, absorptive stubs, and common‐mode suppression (CMS) networks. The resonance conditions of the diode‐loaded dual‐mode resonator in both on/off states, as well as the design principles of the balanced SBPF's, are analyzed and derived. To verify the design concept, a balanced SBPF prototype with a center frequency of 2.6 GHz was designed and manufactured. The measured results show that the proposed SBPF exhibits low DM insertion loss and a wide DM reflectionless bandwidth in the on‐state, high DM isolation in the off‐state, and effective CMS.
High-resolution direct magnetic resonance imaging fistulography with hydrogen peroxide for diagnosing anorectal fistula: A preliminary retrospective study
Authors: Chang Can-Can , Qiao Long-Hu , Zhang Zhen-Qi , Tian Xiao , Zhang Yu , Cheng Wen-Wen , Wang Xia , Yang Qing
Published: January 2025

BACKGROUND

Fistula-in-ano is an abnormal tunnel formation linking the anal canal with the perineum and perianal skin. Multiple imagining methods are available to evaluate it, among which magnetic resonance imaging (MRI) is the most advanced noninvasive preoperative method. However, it is limited in its visualization function.

AIM

To investigate the use of intraluminal MRI for perianal fistulas via a novel direct MRI fistulography method.

METHODS

We mixed 3% hydrogen peroxide (HP) with gadolinium for HPMRI fistulography, retrospectively analyzing 60 cases of complex/recurrent fistula-in-ano using physical examination, trans-perineal ultrasonography (TPUS), low-spatial-resolution MRI, and high-resolution direct HPMRI fistulography. We assessed detection rates of fistula tracks, internal openings, their relationship with anal sphincters, and perianal abscesses using statistical analyses, including interobserver agreement (Kappa statistic), and compared results with intraoperative findings.

RESULTS

Surgical confirmation in 60 cases showed that high-resolution direct HPMRI fistulography provided superior detection rates for internal openings (153) and fistula tracks (162) compared to physical exams, TPUS, and low-spatial-resolution MRI (Z > 5.7, P < 0.05). The effectiveness of physical examination and TPUS was also inferior to that of our method for detecting perianal abscesses (54) (Z = 6.773, 3.694, P < 0.05), whereas that of low-spatial-resolution MRI was not significantly different (Z = 1.851, P = 0.06). High-resolution direct HPMRI fistulography also achieved the highest interobserver agreement (Kappa: 0.89, 0.85, and 0.80), while low-spatial-resolution MRI showed moderate agreement (Kappa: 0.78, 0.74, and 0.69). TPUS and physical examination had lower agreement (Kappa range: 0.33-0.63).

CONCLUSION

High-resolution direct HPMRI fistulography enhances the visualization of recurrent and complex fistula-in-ano, including branched fistulas, allowing for precise planning and improved surgical outcomes.
Impact of sodium-glucose cotransporter-2 inhibitors on pulmonary vascular cell function and arterial remodeling
Authors: Zhang Jing-Jing , Ye Xue-Rui , Liu Xue-Song , Zhang Hao-Ling , Qiao Qian
Published: January 2025

Sodium-glucose cotransporter-2 (SGLT-2) inhibitors represent a cutting-edge class of oral antidiabetic therapeutics that operate through selective inhibition of glucose reabsorption in proximal renal tubules, consequently augmenting urinary glucose excretion and attenuating blood glucose levels. Extensive clinical investigations have demonstrated their profound cardiovascular efficacy. Parallel basic science research has elucidated the mechanistic pathways through which diverse SGLT-2 inhibitors beneficially modulate pulmonary vascular cells and arterial remodeling. Specifically, these inhibitors exhibit promising potential in enhancing pulmonary vascular endothelial cell function, suppressing pulmonary smooth muscle cell proliferation and migration, reversing pulmonary arterial remodeling, and maintaining hemodynamic equilibrium. This comprehensive review synthesizes current literature to delineate the mechanisms by which SGLT-2 inhibitors enhance pulmonary vascular cell function and reverse pulmonary remodeling, thereby offering novel therapeutic perspectives for pulmonary vascular diseases.
Profiling and bioinformatics analyses of circular RNAs in myocardial ischemia/reperfusion injury model in mice
Authors: Wang Jiao-Ni , Zhou Ying-Ying , Yu Yong-Wei , Chen Jun
Published: January 2025

BACKGROUND

Myocardial ischemia/reperfusion (I/R) injury, which is associated with high morbidity and mortality, is a main cause of unexpected myocardial injury after acute myocardial infarction. However, the underlying mechanism remains unclear. Circular RNAs (circRNAs), which are formed from protein-coding genes, can sequester microRNAs or proteins, modulate transcription and interfere with splicing. Authoritative studies suggest that circRNAs may play an important role in myocardial I/R injury.

AIM

To explore the role and mechanism of circRNAs in myocardial I/R injury.

METHODS

We constructed a myocardial I/R injury model using ligation of the left anterior descending coronary artery, and evaluated the success of the validated model using triphenyltetrazolium chloride and hematoxylin-eosin staining. Then, left ventricular samples from different groups were selected for mRNA-sequence, and differential gene screening was performed on the obtained results. The differentially obtained mRNAs were divided into up-regulated and down-regulated according to their expression levels, and Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) functional enrichment analysis were performed, respectively. Then, the obtained circRNA and microRNA (miRNA) were paired for analysis, and the binding sites of miRNA and mRNA were virtual screened. Finally, the obtained circRNA, miRNA and mRNA were constructed by ceRNA mutual most useful network.

RESULTS

We used an RNA sequencing array to investigate the expression signatures of circRNAs in myocardial I/R injury using three samples from the I/R group and three samples from the sham group. A total of 142 upregulated and 121 downregulated circRNAs were found to be differentially expressed (fold change ≥ 2, P < 0.05). GO and KEGG functional analyses of these circRNAs were performed. GO analysis revealed that these circRNAs were involved mainly in cellular and intracellular processes. KEGG analysis demonstrated that 6 of the top 20 pathways were correlated with cell apoptosis. Furthermore, a circRNA-miRNA coexpression network and ceRNA network based on these genes were constructed, revealing that mmu-circ-0001452, mmu-circ-0001637, and mmu-circ-0000870 might be key regulators of myocardial I/R injury.

CONCLUSION

This research provides new insights into the mechanism of myocardial I/R, which mmu-circ-0001452, mmu-circ-0001637, and mmu-circ-0000870 are expected to be new therapeutic targets for myocardial I/R injury.
Global hotspots and trends on environmental exposure and cardiovascular disease from 1999 to 2022
Authors: Zhang Xin-Jie , Tan Qing , Xu Zheng-Yu , Wen Song , Chen Shu-Bo
Published: January 2025

BACKGROUND

The increasing risk of cardiovascular disease (CVD) associated with worsening environmental exposure is a critical health concern garnering global research attention.

AIM

To systematically assess the scope and characteristics of research on the relationship between environmental exposure and CVD.

METHODS

A thorough examination of publications on the relationship between environmental exposure and CVD from 1999 to 2022 was carried out by extensively screening the literature using the Web of Science Core Collection. The language of the selected publications was standardized to English. Afterward, different academic tools such as CiteSpace, VOSviewer, HistCite, Python, Matplotlib, and Bibliometrix were utilized to examine the research trends in this field.

RESULTS

The study’s findings indicated a steady increase in scientific publications among the 1640 analyzed documents, peaking in 2022 with 197 publications. The United States emerged as the leading nation regarding high-quality publications and international collaboration. Harvard University was identified as the most prolific institution. “Environmental research” was the most frequently contributing journal, and Muenzel T was recognized as the top contributor. Current research hotspots are primarily concentrated on themes such as “cardiovascular disease”, “exposure”, “risk”, “mortality”, and “air pollution”.

CONCLUSION

This study highlights increasing research on the link between environmental exposure and CVD, identifying key exposures and diseases while emphasizing the need for further investigation into underlying mechanisms.
Predictive value of the systemic immune inflammation index in recurrence of atrial fibrillation after radiofrequency catheter ablation
Authors: Berezin Alexander E
Published: January 2025

The recurrence of atrial fibrillation (AF) in patients after successful radiofrequency catheter ablation (RFCA) appears to be an unresolved clinical issue and needs to be clearly elucidated. There are many factors associated with AF recurrence, such as duration of AF, male sex, concomitant heart failure, hemodynamic parameters, chronic obstructive pulmonary disease, hypertension, obstructive sleep apnea, hyperthyroidism, smoking and obesity. However, the inflammatory changes are strongly associated with electrical and structural cardiac remodeling, cardiac damage, myocardial fibrotic changes, microvascular dysfunction and altered reparative response. In this context, biomarkers reflecting the different stages of AF pathogenesis deserve thorough investigation. The authors of the retrospective study revealed that one-year recurrence rate of non-valvular AF in the high systemic immune inflammation (SII) index group was significantly increased compared to that of the low SII index group and provided additional predictive value to the APPLE. Furthermore, the authors suggest that this biomarker may help physicians to optimize the selection of AF patients and to develop a personalized treatment approach. In conclusion, the SII index may serve as a valuable indicator of recurrent AF in patients after RFCA and may be a biomarker with plausible predictive value for poor clinical outcomes.
Therapeutic use of music listening in patients undergoing invasive coronary procedures: A meta-analysis
Authors: Siddiqi Ahmed Kamal , Shafiq Aimen , Ahmed Mushood , Anwer Anusha , Maniya Muhammad Talha , Ahmed Aymen , Chachar Muhammad Azhar , Hasibuzzaman Md Al
Published: January 2025

BACKGROUND

Listening to music has been shown to reduce pain and anxiety before, during, and after invasive coronary procedures.

AIM

To perform a systematic review and meta-analysis to explore the effect of therapeutic use of music on both, perioperative and postoperative outcomes of invasive coronary procedures.

METHODS

An exhaustive literature search of 3 electronic databases (MEDLINE, Scopus, Cochrane CENTRAL) was conducted from inception until 10th December 2023. The results of our analyses are presented as standard mean difference (SMD) or weighted mean difference, with 95%CI and pooled using a random effects model. A P value < 0.05 was considered significant in all cases.

RESULTS

From 21 studies, 2141 participants were included in our analysis. The pooled analysis demonstrated that music listening significantly improves post-procedural pain (SMD = -0.78, 95%CI: -1.34 to -0.23; P = 0.006), anxiety (SMD = -0.86, 95%CI: -1.43 to -0.29; P = 0.003), heart rate [mean difference (MD) = -3.38, 95%CI: -5.51 to -1.25; P = 0.002], and systolic blood pressure (MD = -5.89, 95%CI: -9.75 to -2.02; P = 0.003). There was no significant improvement in diastolic blood pressure (MD = -3.22, 95%CI: -6.58 to 0.14; P = 0.06) or respiratory rate (MD = -0.97, 95%CI: -1.98 to 0.03; P = 0.06).

CONCLUSION

Music listening can be used in healthcare settings for patients undergoing invasive coronary procedures to reduce anxiety levels and improve their physiological parameters.
Aproximación ética a la inteligencia artificial desde una óptica humanista cristiana
Authors: Jarabo Carbonell Ferran
Published: January 2025

Este trabajo analiza algunos temas de inteligencia artificial y ética. Desde una óptica humanista pone en el centro la reflexión antropológica para pasar a una exploración de la dimensión ética. En definitiva, el artículo realiza una defensa del ser humano, indaga sobre la responsabilidad ética de esa ciencia y muestra gran interés en que todos (pobres y ricos) se vean beneficiados por sus avances. La inteligencia artificial nos obliga a reflexionar de nuevo sobre los procesos éticos. Durante un tiempo parecía que la ética de esta ciencia estaba dominada por filosofías transhumanistas. Es hora de poner al hombre en todas sus dimensiones en el centro del pensamiento.
La raíz de la gnoseología jurídica en Francisco de Vitoria y Domingo de Soto
Authors: Mercant Simó Jaime
Published: January 2025

Tanto en Francisco de Vitoria como en Domingo de Soto, cofundadores de la llamada Escuela de Salamanca, encontramos un cuidadoso tratamiento acerca de la gnoseología jurídica. El objeto del presente estudio consiste en el análisis de una serie de pasajes textuales en los que se demuestra la raíz iusnatural de ambas doctrinas. Vitoria y Soto, al mismo tiempo que consideran los preceptos de la ley natural como obligatorios e indispensables, enseñan que existe una serie de grados de conocimiento iusnatural. Con todo, no conviene perder de vista que la ley y el derecho naturales no son, para estos autores, unos elementos extrajurídicos; la ley positiva civil debe derivar de la ley natural y debe ser conforme al derecho natural. En esto estriba, pues, la importancia del acceso cognoscitivo del hombre a dicho fundamento iusnatural, fuente primera de toda deontología legal y jurídica.
Francisco de Vitoria y el fundamento del dominium
Authors: Langella Simona
Published: January 2025

Se explora el fundamento que proporciona Vitoria al dominium rerum, es decir, la capacidad del hombre de ser dueño de las cosas. En primer lugar, exponemos sucintamente la concepción vitoriana de la teología como saber que puede y debe ocuparse de cuestiones temporales. Después, se estudia el tema del dominio en su comentario al tratado De restitutione de la Summa theologiae de Tomás de Aquino. Por último, se examina cómo aborda la capacidad humana de dominio en la relectio De indis, donde defiende que los indios americanos son capaces de gobernarse a sí mismos y tener propiedades. Vitoria desarrolla el pensamiento de Tomás de Aquino aplicándolo a nuevos problemas. Según Vitoria, el fundamento del dominio sobre las cosas se encuentra en el dominio sobre uno mismo, que se apoya, a su vez, en la naturaleza humana. Por consiguiente, gozan de dominio incluso las personas que sólo puedan hacer un uso limitado de su razón y su libertad.
Impact of Intrinsic Religiosity, Extrinsic Religiosity, and Cultural Factors on Buying Behaviour
Authors: Nayee Paresha J. , Rathod Harishchandra Singh
Published: January 2025

Understanding cultural influences and religion has been crucial in consumer behavior. To be successful, marketers need to be aware of these factors in any nation or area. India is a diverse nation in many aspects. People in India adhere to various religious and cultural traditions. Every Indian state has its own culture, language, and way of life. Gujarat is among the nation's progressive states. Gujarat is crucial to the development and identity of India, both economically and culturally. It is a sizable and promising market for businesses. The current study examined how cultural and religious considerations influence Gujarati consumers' purchasing decisions. Extrinsic and intrinsic religiosities are the two sub dimensions of Religiosity. A total of 207 samples were gathered using the non probability convenience sampling technique throughout Gujarat. Multiple regression analysis was done to determine the impact. The dependent variable was purchasing Behavior, while the independent variables were cultural aspects and internal and external Religiosity. According to the findings, extrinsic Religiosity influences consumer behavior the most. Cultural influences and inherent Religiosity have an impact, respectively.
PRAVO POTROŠAČA NA ODUSTANAK OD UGOVORA U PRAKSI SUDA PRAVDE EVROPSKE UNIJE
Authors:   University of Kragujevac, Faculty of Law, Serbia, Vujisić Dragan
Published: January 2025

The consumer's right to withdraw is an instrument for achieving a policy of high
level of consumer protection in the European Union. It has been enshrined in the
Directive 2011/83 EU on consumer rights and implemented in the national legislation
of EU member states. It is also implemented in Serbian law through the Law on
Consumer Protection. However, even before that, there were predecessors of this
right in the national laws of individual countries, e.g. in Germany (1969), but also in
the Serbian Law on Obligations (1978).
In EU law, in the national laws of member states, as well as in states that aspire
to be members (therefore, also in Serbia), consumers are entitled, in the case of
concluding a consumer contract outside the trader’s business premises, as well as
when concluding a contract at a distance, in a relatively short period, to withdraw
from the contract, without citing any reasons, and without any negative
consequences. A justifiable reason for giving consumers the right to withdraw from
the contract is that they conclude contracts hastily in these situations; sometimes they
are tempted to enter into contracts that may be harmful to their interests and for
which, after sober reflection, they subsequently repent; they could also be
"manipulated" by aggressive marketing methods. However, this right of consumers is
also criticized, e.g. whether this one is needed in addition to the already existing
instruments for protection; further, this right can also lead to consumer abuse etc.
Although, at first glance, it is comprehensively regulated, the consumer's right to
withdraw from the contract is not deprived of certain situations that lead to court
disputes. Hence, the subject of this paper is the presentation of (only) some of the
cases that the Court of Justice of the European Union had in its practice.
NEKOLIKO NAPOMENA U VEZI SA FINANSIJSKOM AUTONOMIJOM NAJNIŽIH ADMINISTRATIVNO- TERITORIJALNIH JEDINICA TOKOM TZV. ZLATNOG PERIODA KOMUNE U JUGOSLAVIJI (1963-1967) –PRILOG RASPRAVAMA O RAZVITKU LOKALNE SAMOUPRAVE
Authors:   University of Kragujevac, Faculty of Law, Serbia, Bačanin Vojislav
Published: January 2025

In terms of evaluating the existence of self-government of the lowest
administrative-territorial units during the so-called golden period of the commune in
Yugoslavia (1963-1967), in domestic legal theory, there are divergent views. There
are opinions that the system at that time enabled the development of local self-
government, and, on the other hand, there are also views that it was more about the
appearance of self-government and about a system that is not comparable to the "classic" local self-government. The author tries to test anew the hypothesis about the
existence of local self-government in this period through the presentation of the
normative framework and more significant doctrinal reviews regarding the issue of
financial autonomy. The goal is to provide the possibility of a broader and more
effective overview of the development of this political-legal institute.
Analisis Penggunaan Sistem Manajemen Mutu Iso/Iec 17025:2017 pada Laboratorium Pengujian Material Konstruksi Kabupaten Badung
Authors: Widyarsana I Putu , Suhardiyani Putu Eny
Published: January 2025

Accreditation of ISO/IEC 17025: 2017 for laboratory is carried out to guarantee the testing quality conducted by a laboratory. The Badung Regency Construction Materials Testing Laboratory is one of the government laboratories that has implemented the SNI ISO/IEC 17025:2008 quality management system and has been accredited by KAN (National Accreditation Committee). To be able to continue accreditation from KAN, the laboratory plans to take acreditation of ISO / IEC 17025 version 2017. This study aims to analyze the implementation of  Laboratory quality management system that is measured according to the clauses of ISO / IEC 17025: 2017 and to develop strategies that can be performed  to improve the implemention of ISO / IEC 17025: 2017. In phase I, data collection was conducted through interviews using checklist developed based on ISO / IEC 17025: 2017. The implementation was assesed based on of the quality standards ISO / IEC 17025: 2017 (clause 4 to clause 8). The results showed that  the implementation of ISO / IEC 17025: 2017  was in good category with score of 75,91%. While, atphase II, data collection was conducted through Focus Group Discussion (FGD) to develop strategies that can be performed by the company to succeed the implementation of ISO / IEC 17025: 2017. The identified strategies include rearranging documents of the laboratory task and authority of laboratory personnel related to organizational structure, responsibility, training of lab personnel, implementation of laboratory quality management systems, conducting risk analysis to determine risk management actions in each work procedure so that work processes can be more efficient to produce products and services according to requirements that meet customer satisfaction.
BLENDED LEARNING IN ACCOUNTING EDUCATION: A COMPARATIVE ANALYSIS OF LEARNING THEORIES
Authors: Kottara Chara , Asonitou Sofia , Kavalieraki-Foka Dimitra , Georgopoulou Maria Sofia , Brinia Vasiliki
Published: January 2025

Learning theories reconstruct complex cognitive processes and provide useful mental models for the structure and design of courses. However, even for the most experienced professors, exploring them remains a challenge. Researchers around the world consider the development of theoretical models that contribute to the process of knowledge construction and experiential learning to be essential. In recent decades, there has been an increasing trend in the design of accounting courses through the integration of technology into traditional teaching. This has resulted in the emergence of new perspectives through the adoption of a blended teaching approach. This research deals with the investigation, analysis, and comparison of four fundamental learning theories: Behaviorism, Cognitivism, Constructivism, and Connectivism. Its contribution lies in the scientific documentation of the suitability of the theories that align with the needs within the framework of blended learning. The findings of the research are drawn from the literature review and the implementation of an experiment in an undergraduate accounting course. A blend of two theories emerged that align optimally in blended environments; specifically, the theories of constructivism with an emphasis on the social aspect and connectivism show a strong correlation, promoting student-centered teaching which increases student engagement by enhancing their knowledge and skills.
 

 Article visualizations:
INVESTIGATING THE RELATIONSHIP OF READING COMPREHENSION ON THE SOLUTION PROCESSES OF MATHEMATICAL WORD PROBLEMS
Authors: Obina Jeremias E. , Tecson Rhoda Queenie S. , Kalis Gaddah Lea G. , Bura-ay Deo C.
Published: January 2025

This study investigates the relationship between reading comprehension and the solution processes of mathematical word problems and the difference in the solution processes in solving mathematical word problems when grouped according to reading comprehension skills. A descriptive-correlational research design was utilized to explore this relationship, while causal-comparative analysis was employed to examine these differences. The study included one hundred seventy-nine (179) students from Grades 7 to 10 enrolled in a private institution for the school year 2023-2024. The findings revealed that junior high school students exhibited poor levels in their reading comprehension skills, and their solution processes in solving mathematical word problems were at a low level. The investigation showed no significant relationship between respondents’ reading comprehension skills and their ability to solve mathematical word problems, indicating a weak positive relationship. Moreover, the findings indicate that there is a significant difference between the respondents' solution processes in solving mathematical word problems when grouped according to frustration/poor, instructional, and independent. The poor level, representing the lowest proficiency in reading, exhibits higher performance in solving mathematical word problems compared to the instructional level, which is at a middle proficiency level. The independent level, representing the highest proficiency in reading, demonstrates the highest performance in solving mathematical word problems compared to the other two levels.
 

 Article visualizations:
Нарративная субверсия и деконструкция мифа в романе Мадлен Миллер «Песнь Ахилла»
Authors: Gonchar-Khanjyan Natalie , Сафарян Марта
Published: January 2025

This article examines the modern ‘’feminine’’ interpretation of a canonical plot, which originated in Homer’s epic, and has long been viewed as one of the most ‘’masculine’’ in literature. The aim of this article is to deal with the deconstruction of the myth of Achilles in contemporary literature, comparing and contrasting Homer’s Achilles with the image of the ancient hero according to contemporary female authors. The focus is particularly on the text of popular novelist Madeline Miller, which implicitly differs from the traditionally accepted purely masculine interpretation. The subject of the study is the modern concept of the well-known plot and image. The growing interest in new variations of canonical images, the search for and interpretation of intertextual convergences by writers, critics, and readers determines the topicality of this theme. Despite the engaging storyline and un¬deniable philological merits of the book, which are fully preserved in the Russian translation, as well as the abundance of brief reviews and internet dis¬cussions, Miller's novel is not presented in scientific discourse, which defines the novelty of this article, with a comparative method in its core.
ՄԵՂՄԱՍՈՒԹՅՈՒՆՆԵՐԸ ԺԱՄԱՆԱԿԱԿԻՑ ԴԻՎԱՆԱԳԻՏԱԿԱՆ ԴԻՍԿՈՒՐՍՈՒՄ
Authors: Կնյազյան Աննա , Ղուկասյան Վարդուհի
Published: January 2025

The present article engages with euphemisms which are used as a means of implementing the strategy of evasion of truth in English-language diplomatic discourse. The aim of the study is to identify the functions of euphemisms in the diplomatic discourse of the English media. The relevance of the research is due to the insufficient study of the functions of euphemisms in diplomatic discourse (on the example of the English language). Euphemism is a word or phrase that replaces a taboo word or serves to avoid unpleasant expressions. In social communication euphemism is important to create harmonious interaction. Diplomatic euphemisms are considered as words and expressions used in the language of diplomats instead of undesirable words and expressions in order to hide, soften or distort the meaning of the events and phenomena covered. The study examined the language material collected from the British and American media publications of 2020-2023. The analysis was based on the application of the componential, distributive, and contextual methods, as well as the quantitative research methods, contributing to a deeper understanding of the structure, semantics, and pragmatic nature of political euphemisms in modern English.
Թվային դիվանագիտության լեզվական առանձնահատկությունները
Authors: Ղուկասյան Վարդուհի
Published: January 2025

The purpose of this article is to consider the strategies of digital diplomacy as a new means of communication, the linguistic features of communication platforms, as well as the functional features of discursive genres of diplomatic communication in the virtual space. The relevance of the study is also due to the insufficient coverage in the linguistic literature of new genres and communication strategies of digital diplomacy. The current level of the development of diplomatic discourse using IT technologies on the Internet allows us to talk about the emergence of digital diplomacy as a new form of diplomatic discourse. Each website of a diplomatic department must have a link to official accounts on various social networks. The list of social networks used is varied, but the main ones in digital diplomacy are Facebook and Twitter, which offer users a wide range of communication opportunities. Digital diplomacy is changing the rules of the game in international relations. The use of networks has changed the practice of information and analytical work of diplomats, strategy planning, implementation  of protocol events and organization of negotiations. Employees of foreign policy departments and international organizations act as organizers of online discussions, which  allows them to directly influence the perception of information content by the target audience.
Fostering Critical Thinking Skills in the HEIs of Armenia in the Age of AI-driven Transformation
Authors: Sargsyan Lilit
Published: January 2025

Higher education is experiencing significant changes due to technological advancements, learner-centered approaches, and evolving societal needs. This paper examines the urgent need for integrating critical thinking skills into Armenian higher education in light of AI-driven transformations and the country’s emerging AI industry.
To address the need for critical thinking (CT) skills, a comprehensive framework comprising Universal, Mixed, and Infusion approaches should be introduced in HEIs to offer various ways to nurture CT, from dedicated courses to integration across disciplines and the entire curriculum, as well as selected models such as Pearson's RED Model, Bloom’s Taxonomy, and the Paul-Elder Model as effective tools for promoting CT among students. These frameworks provide guidelines for recognizing assumptions, evaluating arguments and drawing conclusions, that enables students to engage critically with AI-generated insights.
Moreover, a holistic approach to the development of CT among students, who are not yet ‘AI natives’, is bound to the cultivation of a CT mindset characterized by integrity, autonomy, and empathy. This mindset enables students to approach AI with skepticism and fosters a culture of innovation and ethical decision-making.
The mentioned frameworks cannot generate the anticipated outcomes unless CT skills development becomes an integral part of the CPD of teaching staff on institutional and national level as well.
In conclusion, integrating critical thinking skills into the HEIs of Armenia is crucial in the AI-driven era. By adopting comprehensive approaches and fostering a critical thinking mindset among students, universities will prepare graduates capable of navigating the complexities of the modern world effectively.
Keywords: critical thinking skills, AI-driven transformation, CPD, learner-centeredness, critical thinking approaches and models, Active learning methods, evidence assessment.
Հեղինակային «ես»-ի արտացոլումը Վաշինգտոն Իրվինգի փոքր արձակում
Authors: Ամիրյան Աննա
Published: January 2025

In this paper, Washington Irving's authorial ''ego'', the founder of American romanticism, is studied. The article presents how the writer's personality and his works complement each other, parallelling and revealing their direct inter­connection, as well as considers some structural and content features of the writer's works, particularly short prose. The reserved, balanced and insightful type of the writer is clearly reflected especially in his short stories and novellas. There are no extremes either in his life or in his literary works. Irving's stories are characterized by calmness, lightness, delicacy, harmony, humor and deep meaning at the same time. The short prose of the author is dominated by descriptive passages, which are complemented by various details and illustrative scenes. However, there is almost always a lack of action here. The writer, being self-absorbed, also avoided writing long and boring texts, instead preferring brief but at the same time meaningful, smooth and beautiful speech. An impression is created that everything is real, and the reader is a direct witness of those scenes and images.
Analisis Ketergantungan dalam Hubungan Tiongkok dengan Hong Kong, Taiwan dan Makau dalam Era Globalisasi
Authors: Alfriani Yuniar Zahra , Fridiyanti Yulita Nilam
Published: January 2025

Hubungan antara Tiongkok, Taiwan, Makau, dan Hong Kong menjadi fokus internasional karena mencerminkan berbagai dinamika politik, ekonomi, dan sosial yang kompleks dalam isu internasional. Tiongkok mengklaim Taiwan sebagai bagian dari wilayahnya dan secara resmi Makau serta Hong Kong kembali ke kedaulatan Tiongkok di bawah otonomi khusus yaitu kebijakan “one country,two systems”. Dalam Politik Internasional ini sangat penting karena melibatkan batas kedaulatan negara dan identitas nasional, ini berdampak langsung pada stabilitas wilayah Asia Timur. Penelitian ini menggunakan pendekatan kualitatif karena memungkinkan analisis terhadap sejarah, konteks sosial-politik, ekonomi, dan karakteristik unik dari setiap wilayah. Menggunakan sumber yang diperoleh dari jurnal, buku, dan website, penelitian ini menemukan secara ekonomi Hong Kong, Taiwan, dan makau sangat bergantung pada Tiongkok. Namun secara Sosial menjadi tantangan besar bagi Tiongkok dalam menghadapi aspirasi identitas lokal dan krisis kepercayaan Hong Kong dan Taiwan terhadap pemerintah Tiongkok.
Komunikasi Pembangunan Berbasis Komunitas dalam Upaya Pemberdayaan Perempuan
Authors: Heni Setiawati  , Firmansyah Iqbal , Salsabila Riesqa Marsya , Purwanto Eko
Published: January 2025

Pemberdayaan perempuan merupakan isu strategis dalam pembangunan berkelanjutan, terutama di tingkat komunitas lokal. Penelitian ini bertujuan untuk menganalisis efektivitas komunikasi pembangunan berbasis komunitas dalam mendukung pemberdayaan perempuan di berbagai daerah Indonesia, termasuk pedesaan dan perkotaan. Pendekatan kualitatif dengan metode studi literatur digunakan untuk mengkaji berbagai hasil penelitian dan laporan terkait. Hasil kajian menunjukkan bahwa komunikasi pembangunan berbasis komunitas dapat meningkatkan kesadaran perempuan terhadap hak-hak mereka, memperkuat keterampilan, dan mendorong partisipasi aktif dalam kegiatan sosial, ekonomi, dan pengambilan keputusan. Pendekatan partisipatif menjadi kunci keberhasilan, di mana komunitas dilibatkan dalam setiap tahap perencanaan dan pelaksanaan program. Kesimpulannya, komunikasi pembangunan berbasis komunitas efektif dalam mendukung pemberdayaan perempuan, terutama jika melibatkan strategi yang inklusif dan berorientasi pada kebutuhan lokal. Studi ini merekomendasikan penguatan kebijakan berbasis komunitas untuk mempercepat pencapaian kesetaraan gender dan pembangunan berkelanjutan di Indonesia.
O rio Tauá como instrumento pedagógico
Authors: Silva Luiz Eduardo da , Modesto Regiara Croelhas , Nascimento Jeane Cleide Bernardino , Reis Amy Marinho dos , Silva Vivian Soares e
Published: January 2025

Este artigo tem como objetivo geral apresentar propostas pedagógicas elaboradas em conjunto com os professores de uma escola do campo, para atender as peculiaridades do campo, das águas e das florestas, em especial na região amazônica. Os objetivos específicos apresentados são: compreender, através das narrativas, as relações dos moradores mais antigos da comunidade com o rio Tauá, bem como realizar oficina com os professores das disciplinas Geografia, Ciência, Arte e História, para elaborar propostas pedagógicas destinadas aos alunos do 6º ano. Para tanto, o procedimento metodológico fez uso da pesquisa qualitativa, considerando os enlaces da história oral, realizada em uma escola do campo, em Santo Antônio do Tauá (PA), com 8 sujeitos, sendo 3 professoras e 5 moradores mais antigos da comunidade. Os resultados revelam a necessidade de os professores desenvolverem práticas que promovam uma aprendizagem significativa na formação de estudantes críticos e reflexivos, utilizando o rio Tauá como instrumento pedagógico.
Effectiveness of Digital Project-Based Science Learning in Optimizing Student’s Creative Thinking Skills: Alignment with SDG 4 in Higher Education
Authors: Prahani Binar Kurnia , Trianggono Mochammad Maulana , Zahro Ianatuz , Siswono Hendrik , Ashadi Firman , Saphira Hanandita Veda
Published: January 2025

Objective: The objective of this study is to determine the feasibility of digital project-based learning that has been developed and its effectiveness in optimizing students' creative thinking skills in science learning.
 
Theoretical Framework: The integration of digital media in learning in higher education will have an impact on stimulating and optimizing the potential creative thinking in students. A project-based learning process combined with digital integration is needed as a target for project development and SDGs in Education.
 
Method: This research uses True-Experimental Design which consists of 1 control class and 3 experimental classes. Data analysis used in this study included N-Gain analysis to determine the increase in students' creative thinking skills, Wilcoxon test analysis to determine the significance of differences in pre and post-tests, and Mann-Whitney U test analysis to determine the significance of differences in students' creative thinking skills between control classes and experimental classes.
 
Results and Discussion: The results showed that the digital project-based science learning that has been developed is feasible (valid and reliable) and can effectively optimize students' creative thinking skills. The increase in the n-gain score in the control class was 0.302 with a moderate category, while in the experimental class 1 it was 0.705, experiment 2 was 0.703 and experiment 3 of 0.704 with a high category.
 
Research Implications: The implications of these findings are significant, providing new insights into the innovative learning, especially the optimalization of Digital Project-Based Science Learning in Optimizing Students' Creative Thinking Skills in Higher Education for future research.
 
Originality/Value: The novelty of this research lies in the integration of digital product development for early childhood into project-based science learning.
A SURVEY OF DIMENSION OF POSETS
Authors:   Modern College of Arts, Science and commerce (Autonomous), Shivajinagar,Pune 5., V. Ubale Vaibhav , N. Bhavale Ashok ,   Modern College of Arts, Science and commerce (Autonomous), Shivajinagar ,Pune 5.
Published: January 2025

In 1930, E. Szpilrajn proved that any order relation on a set $X$ can be extended to linear order on $X$. It also follows that order relation is the intersection of its linear extensions. In 1941 Dushnik and Miller introduced the concept of dimension of a poset $(X,P)$, denoted $Dim(X,P)$, as the smallest positive integer $n$ for which there exist linear extensions $L_1, L_2, ..., L_n$ of $P$ so that $P=L_1\cap L_2\cap ...\cap L_n$.
In this paper, we do literature survey of the research articles on dimension theory of posets. This survey provides an overview of key concepts, results, and challenges in dimension theory of posets. The survey also examines advanced topics like fractional dimension, geometric representations, and topological considerations. Open problems and future research directions, emphasizing the interdisciplinary potential of dimension theory in mathematics and computer science.
New theorems of Laplace Kernels with Radon measures in Galerkin Markov-State Models: about time evolution of eigenvalues and about errors
Authors:   Sapienza University of Rome,Rome, Italy., Maria Lecian Orchidea
Published: January 2025

New theorems apt to the methods of the Markov-State Models in the Galerkin representation are derived directly from the Markov-chains theories. The analytical expressions of the time evolution of the eigenvalues and those of the relative error are derived. The new theorems are descended from measuretheory methodologies. The newly-written theorems therefore provide wit the analytical expressions of the time evolution of the eigenvalues and with that of the relative error from the measure-theoretical foundations of the Markov-chains models; the applications to protein folding are originated form the orthogonality of the committor functions in the appropriate description(s). The newly-found theorems are indicated of use for the other necessitated errors calculations. The modellisation used is one apt to recover the items of information about the originating chains.

Markov-chains models offer the suitable tools of a wide range of investigation branches: protein-folding, catalysis, polymeric materials, further moleculardynamics processes, kinetic-network models, electron spin resonance, etc.