bluuebunny/crossref_metadata_2025 huggingface dataset:
Kajian Teknis Design Life of Mine (LOM) Tambang dengan Potensi Kerjasama Sharing Wall Project Melalui Pendekatan Analisis Kestabilan Lereng
Authors: Wibowo Wahyu , Nurhakim Nurhakim
Published: August 2024

Dalam menerapkan kaidah pertambangan yang baik, Kepmen ESDM No 1827 memberi pedoman tentang pelaksanaan konservasi batubara yang salah satunya dengan penambangan bersama pada perbatasan IUP. Penambangan bersama disebut dengan Sharing Wall Project yang bertujuan untuk mengoptimalkan pencapaian recovery penambangan cadangan marginal.  Secara teknis, Sharing Wall Project baru bisa dikerjakan apabila kedua perusahaan menambang secara bersamaan di perbatasan IUP dengan parameter geometri dan kebijakan yang telah disepakati sebelumnya. Oleh karena itu diperlukan adanya Opsi Design LOM yang aman dikerjakan selama proses persiapan dilakukan juga untuk mengantisipasi jika tidak terjadi kesepakatan kerjasama.  Pembuatan Opsi Design LOM harus mempertimbangkan analisis kestabilan lereng dan potensi jumlah cadangan marginal yang tertinggal. Faktor yang mempengaruhi hasil analisis kestabilan lereng adalah muka air tanah dan overall slope design. Rekomendasi geotek setelah menyatakan Opsi Design LOM aman adalah dengan menambah data muka air tanah dan material properties di area rehandle disposal untuk memperkuat analisis berikutnya. Batubara marginal yang tidak tertambang di perbatasan IUP menjadi gain saat kerjasama Sharing Wall Project dikerjakan. Berdasarkan perhitungan cadangan Opsi Design LOM menghasilkan gain batubara sebesar 2.6 juta ton total untuk kedua perusahaan. Hal ini berarti tambahan pembayaran royalti kepada Pemerintah dari hasil perolehan batubara cadangan marginal di perbatasan IUP.
Performance Analysis of Planning Consultants Working on Projects in South Kalimantan
Authors: Marwizy Gusti Eddy Mulya
Published: August 2024

The purpose of this study was to determine the factors that influence the performance of the planning consultant and to develop recommendations for improvement of these factors. There are 4 aspects that measure its performance, namely; 1) quality of planning documents, 2) aspects of planning time, 3) aspects of planning costs and 4) aspects of terms of reference. Therefore, this study uses 2 analytical methods, namely customer satisfaction index (CSI) importance-performance analysis (IPA). The results of the study indicate that there are several factors that affect the performance of the planning consultant and require priority handling, namely: (1) quality of planning documents: consistency between drawing documents, RKS, and engineer estimates, systematic presentation of design documents and considerations of technology availability and capabilities; and (2) terms of reference which consist of: data collection, spatial program structure, architectural design feasibility, final planning report, suitability of work experience with the position occupied. The recommended handling solution to overcome the performance problems of this planning consultant is to improve the competence of human resources. Human resources include planning consultants, architects and all parties involved in the project planning process, both institutionally managing and improving the management of the implementation of the planners.
A Optimasi Fasilitas Produksi Unit Untuk Meningkatkan Produksi Pelumas (Studi Kasus PT. Pertamina Lubricants, Dengan Fokus Production Unit Cilacap)
Authors: Kartiman Kartiman
Published: August 2024

PLPUC adalah perusahaan yang menggunakan teknologi LOBP untuk memproduksi pelumas. Dalam teknologi tersebut bergantung pada mesin. Salah satu mesinnya adalah filling lithos, dan mesin tersebut memiliki beberapa masalah, yaitu kegagalan produksi akibat kegagalan mesin yang mengakibatkan downtime sehingga target produksi pelumas menurun. Dari permasalahan tersebut, perlu dilakukan mitigasi dan peningkatan kapasitas produksi untuk mengoptimalkan fasilitas di PUC, sehingga salah satu mitigasinya adalah melakukan penggantian preventif untuk menjadwalkan penggantian komponen mesin yang akan rusak sehingga dapat mengurangi downtime dengan menghitung waktu penggantian menggunakan lean six sigma dan penambahan tangki strorage oli dasar sebagai bentuk pressure treatment untuk penambahan kapasitas produksi. Kemudian mitigasi dan penambahan kapasitas produksi menjadi tujuan penelitian ini. Dan bagian dari metode lean six sigma adalah six sigma yang berfungsi untuk menganalisis kemungkinan produk pelumas yang rusak diproduksi, dan sebagai penghapusan limbah dalam waktu henti dari aliran nilai menggunakan lean manufacturing yang menghasilkan nilai tambah. Kemudian untuk mengkaji tingkat produktivitas dan kualitas produksi perusahaan dapat dilihat dari OEE (Overall Equipment Effectiveness) sebagai indikator produktivitas dan tingkat kualitas produksi. Selanjutnya, dari Januari 2010 hingga Desember 2010 PUC memperoleh nilai OEE sebesar 41,95%, dan ini harus ditingkatkan untuk mengoptimalkan fasilitas produksi PUC. Dari OEE PUC terdapat komponen mesin yang rusak yang memerlukan perbaikan/penggantian dan melakukan penggantian preventif berdasarkan masa pakai komponen mesin dan tingkat keandalan kinerja mesin yang diharapkan dapat meningkatkan hal tersebut. Penggantian preventif dapat mengurangi limbah dalam waktu henti produksi dan pemeliharaan tekanan dapat meningkatkan kapasitas produksi sesuai dengan hasil analisis penelitian ini. Dan setelah melakukan ini, nilai OEE awal dapat meningkat sebesar 1,77% menjadi 43,72%.
Pengaruh Hasil UAV atau Drone Dalam Inventarisasi Lahan Untuk Niatan Penggunaan Pada Kegiatan Pembebasan Lahan
Authors: Umar Ezra Farabi
Published: August 2024

UAV atau Drone menunjukan pengaruh yang sangat baik dalam kegiatan inventarisasi lahan untuk kegiatan pembebasan lahan berdasarkan kemampuannya dalam pengambilan data. Pada saat ini setidaknya UAV atau drone dapat menyediakan lima jenis data berupa peta orthophoto, peta topografi, foto dengan resolusi tinggi, videografi dan gambar 3D. Penelitian ini ditujukan untuk mengetahui bagaimana pandangan para pelaku pengadaan lahan dalam pengadopsian teknologi drone serta pandangan mereka terhadap data yang dapat dikumpulkan oleh UAV atau Drone. Penelitian ini dilakukan dengan menggunakan Framework Technology Acceptance Model meliputi 280 responden yang berisikan pelaku pembebasan lahan dari berbagai sektor pekerjaan mulai dari perkebunan, pertambangan, perminyakan, dan pekerjaan sipil. Metode pada penelitian ini berupa metode kuantitatif dengan instrument penelitian berupa angket kuesioner. Data yang telah terkumpul kemudian dianalisis dengan menggunakan analisis SEM PLS (Partial Least Square Structural Equation Modeling) dengan menggunakan bantuan program SmartPLS. Hasil dari penelitian menunjukan bahwa kemudahan yang dirasakan, manfaat yang dirasakan, serta hasil yang dimiliki drone berpengaruh terhadap niatan para pelaku pengadaan lahan untuk mengadopsi teknologi UAV atau Drone
Optimalisasi Jumlah Unit Rumah Tiap Tipe Sesuai Kemampuan Daya Beli Masyarakat
Authors: Widiastuti Endah
Published: August 2024

Pertumbuhan jumlah penduduk ini membawa dampak pada perekonomian dan kebutuhan masyarakat akan rumah. Ini menjadi peluang bagi pengembang untuk membuka kawasan perumahan. Pengembang perlu memperhatikan kemampuan daya beli masyarakat agar perumahan yang dibangun optimal dan pengembang bisa menghasilkan keuntungan yang maksimal. Dilakukan penelitian untuk mencari kombinasi jumlah optimal rumah tiap tipe. Batasan tersebut meliputi batasan biaya produksi, batasan luas lahan, batasan waktu pembangunan, dan batasan daya beli masyarakat pada tiap tipe rumah.
Penelitian ini menggunakan Program QM for Windows untuk memproses analisis datanya. Data primer yang digunakan didapatkan dari 50 kuesioner yang disebar dan data sekunder didapatkan berdasarkan informasi pengembang. Hasil optimalisasinya yang didapatkan adalah rumah tipe 36 subsidi sebanyak 45 unit, rumah tipe 36 non subsidi sebanyak 51 unit, rumah tipe 45 sebanyak 39 unit, dan rumah Tipe 50 sebanyak 15 unit. Pengembang menghasilkan keuntungan maksimum sebesar Rp 8.534.000.000,00 dengan jumlah rumah yang dibangun berjumlah 150 unit. Analisis sensitivitas juga dilakukan terhadap kemapuan daya beli masyarakat. Hasilnya kemampuan daya beli masyarakat berpengaruh besar terhadap kombinasi jumlah rumah tiap tipe yang dibagun dan keuntungan yang didapatkan pengembang.
ANALISIS TAMPUNGAN POTENSIAL EMBUNG BLURU UNTUK KEPERLUAN AIR BAKU KECAMATAN BATU AMPAR KABUPATEN TANAH LAUT
Authors: Afrila Humaira , Amalia Maya
Published: August 2024

Pada musim kemarau, Desa Bluru di Kabupaten Tanah Laut, Provinsi Kalimantan Selatan, kerap mengalami kekurangan air. Oleh karena itu, direncanakan pembangunan embung untuk mengatasi masalah tersebut. Embung berfungsi menyimpan air pada musim hujan yang dapat digunakan pada musim hujan maupun kemarau. Beberapa analisis dilakukan untuk membangun bendungan kecil. Analisis yang dilakukan meliputi analisis curah hujan rancangan dengan menggunakan distribusi Log Pearson Tipe III, serta rancangan analisis banjir dengan metode hidrograf satuan sintesis (HSS) Nakayasu. Debit banjir diperkirakan sebesar 76,75 m3/s berdasarkan analisis pada kala ulang 100 tahun. Kebutuhan air di Desa Bluru adalah 45,25 l/hari untuk air domestik dan 2,26 l/hari untuk air non-domestik. Ketinggian Bendung Bluru mempunyai nilai tampungan mati sebesar 231.500,00 m3 dan nilai tampungan efektif sebesar 130.000,00 m3. Struktur bendungan dievaluasi berdasarkan simulasi perangkat lunak oleh Hec RAS. Embung ini diperkirakan memiliki elevasi dasar +55,82 m dan elevasi puncak +62,82 m
PROPORSI SEMEN MUTU 20 MPA PADA BAHU JALAN TANJUNG SELOR-SIMPANG 3 TANJUNG PALAS-SEKATAK BUJI
Authors: Muliadi Heri , Yuliana Candra
Published: August 2024

Paket Preservasi Jalan dan Jembatan Tanjung Selor-SP.3 Tanjuung Palas-Sekatak Buji merupakan salah satu paket yang berada dibawah Satuan Kerja Perencanaan dan Pengawasan Jalan Nasional Balai Pelaksanaan Jalan Nasional (BPJN) Kalimantan Utara. Salah satu kegiatannya adalah perkerasan bahu jalan dengan menggunakan mutu 20 MPa, dimana dalam menentukan maka dilakukan pembuatan sampel beton didalam pengaplikasiannya dilapangan menggunakan proporsi  semen sebanyak 410 kilogram, agregat ukuran 1-2 sebanyak 932,5 kilogram, agregat ukuran 2-3 sebanyak 233 kilogram, pasir sebanyak 524 kilogram dan air sebanyak 205 liter.
Potensi Limbah Fly Ash PLTU Anggrek, Gorontalo Utara sebagai Bahan Substitusi Semen Pada Beton
Authors: Kadarningsih Rahmani
Published: August 2024

Accumulation of coal ash waste (fly ash) is a dangerous toxic material (B3) which light and fine so it easily flies in the air. This problem is urgent to be resolved because the production continues to increase in quantity and can cause air and water pollution. Currently, coal waste is used to make bricks, but research needs to be done on its potential as a concrete mixture and even as a cement substitute. Currently, coal waste is used to make bricks, but research necessery on its potential as a concrete mixture and even as a cement substitute. Therefore this research can be an alternative solution to the coal ash waste problem in Gorontalo Province. Research on the use of coal ash as a concrete mixture using crushed stone aggregate and sand from the quarry PT. CMP, Bonda Raya, South Suwawa To obtain a granular distribution that meets the requirements, the proportions used for crushed stone measuring 1-2 cm and measuring 2-3 cm are 65% and 35% respectively. Meanwhile, to obtain a combined gradation of fine and coarse aggregate that meets the requirements, percentages of 55% and 45% are used respectively. Based on the research results, the normal compressive strength value of concrete is 28.827 MPa. The compressive strength of fly ash variations of 5%, 10%, 15%, and 20% is 25,069 MPa, 27,442 MPa, 23,096 MPa, and 20,934 MPa. The compressive strength of fly ash variations is lower than normal concrete. The optimum compressive strength value for fly ash substitution for cement with a 10% variation is 27.442 MPa.
KAJIAN SEMIOTIKA PADA GAMBAR ANAK DENGAN TEMA KEBERAGAMAN
Authors: Nursanti Rizna Eka , Sri Rumestri Agatha Dinarah , Sari Elita Kurnia
Published: August 2024

Menggambar merupakan suatu petualangan luar biasa yang dialami oleh anak-anak dalam berfantasi. Berbagai objek yang dituangkan dalam gambar bukan sekedar apa yang sedang ia pikirkan, melainkan apa yang dilihat dengan perasaan untuk kemudian diasosiasikan. Berdasarkan tahapan perkembangannya, setiap kelompok rentang usia memiliki karakteristik gambar yang berbeda-beda. Tulisan ini membahas hasil karya pada anak pada rentang usia 9-12 tahun yang sedang berada pada early realism stage, dimana karakteristik gambar cenderung mengarah ke bentuk realistis. Gambar dibahas menggunakan analisis semiotika, dengan mengulas 5 hal, yakni: elemen, posisi, relasi, totalitas dan sistem. Hasilnya terdapat makna tersembunyi dari gambar yang dianalisis yang berisikan pesan terkait persatuan anak-anak di dunia.
PERANCANGAN IDENTITAS VISUAL “PUMP NATION KURVE CHAINLESS COMPETITION”
Authors: Atmami Harry
Published: August 2024

PUMP NATION Kurve Chainless Competition adalah sebuah event kompetisi sepeda di Bandung, tepatnya di Kurve Pump Track yang merupakan salah satu falisitas sepeda di Sindang Reret Cikole. Pada event ini Bank Jabar menjadi sponsor utama, dengan berbagai kelas kompetisi event ini diselenggarakan pada 27-28 Agustus 2022. Penelitian ini menggunakan pendekatan kualitatif dengan metode based project yang disesuaikan dengan client brief, sebagai data pendukung dalam pengumpulan data dilakukan juga observasi, studi literatur dan wawancara. Dari pengumpulan data kebutuhan identitas visual menjadi penting dalam menginformasikan dan mengkomunikasikan identitas dari event tersebut yang sesuai dengan client brief. Identitas visual yang visualisasinya merepresentasikan tentang sponsor utama, sepeda dan Kurve Pump Track dengan visual minimalis dan kontemporer. Hasil penelitian dari project based ini adalah sebuah identitas visual dari event PUMP NATION Kurve Chainless Competition, yang kemudian menghasilkan sebuah visual branding dari event tersebut.
On the Theoretical Intuition of Jungian Archetypes and its Logical Extensions
Authors: Penzance Isaac
Published: August 2024

This article considers the status of Jungian archetypes as potentially divergent bodies. It possesses the initiative to consider the prerogative that they are situated on, and to develop that into discussing the conditions for a differing subjective reality that is derived from Jungian pretenses. This article operates within the boundaries of the conjecture, it serves simply to cover the potentiality for developments outside of the simple basis of the archetype rather than to provide a metaphysical or ontological contribution to psychology. Unlike Jung’s study, which serves a multitude of ideas and draws upon evidential factors from - however generally expressed - ancient civilisations, this article instead seeks to apply that logic for the purpose of explicating the meaning and potential extensions of the “archetypal dogma”.
Construction of Carbon Dioxide Responsive Graphene Point Imbibition and Drainage Fluid and Simulation of Imbibition Experiments
Authors: Yin Peng , Shi Fang , Luo Mingjian , Wu Jingchun , Yu Yanan , Zhang Chunlong , Zhao Bo
Published: August 2024

The global oil and gas exploration targets are gradually moving towards a new field of oil and gas accumulation with nano pore throats, ranging from millimeter scale to micro nano pore throats.There are difficulties in fluid transport in nano confined pore throats, such as strong adsorption, which greatly increases the difficulty of starting crude oil.Therefore, it is necessary to construct a nanoscale fluid with strong diffusion and dispersion, and improve its permeability, suction, and displacement capabilities.This article develops a carbon dioxide responsive graphene dot type surfactant.By characterizing its structure, physical and chemical properties, and conducting infiltration simulation experiments, its infiltration and drainage ability in nanopore throats is elucidated.Infrared spectrum measurement shows that after functional modification exhibit new characteristic peaks at 1600 cm-1 to 1300 cm-1, considering the N-H plane stretching characteristic peak.The fluorescence spectra showed that the fluorescence intensity of F-GQDs was increased after functional modification, which indicated that F-GQDs was successfully synthesized.Through measurements of interfacial activity and adhesion work calculations, the oil-water interfacial tension can achieve ultra-low values within the range of 10-2 to 10-3 mN/m. Oil sand cleaning experiments and indoor simulations of spontaneous imbibition in tight cores demonstrate that F-GQDs exhibit effective oil washing capabilities and a strong response to carbon dioxide. When combined with carbon dioxide, the system enhances both the rate and efficiency of oil washing.Imbibition recovery can reach more than 50%.The research results provide a certain theoretical basis and data reference for the efficient development of tight reservoirs.
A Zassenhaus Lemma for Digroups
Authors: Biyogmam Guy
Published: August 2024

In this paper, we construct a quotient structure on digroups. This construction yields a new functor from the category of digroups to the category of groups. We obtain a modular property for digroups, and use it to prove an analogue of the Zassenhaus Lemma in this framework.
Magnesium Addition and Treatment of Reinforcement Particles in Al6061 – Sea Sand Composite on Coefficients Friction and Wear Rate
Authors: Akbar Hammar Ilham , Atmaja Muhammad Ilham Arbi , Surojo Eko , Kusharjananta Bambang , Fanani Reza Aldiansyah
Published: August 2024

Aluminium matrix composite is a composite material that can be used as reinforcement to increase the tribological properties of composite. The process of manufacturing the Al6061-Sea sand composite used the stir casting method with stirring time of 10 minutes and speed of 600 rpm. Stir casting specimens were manufactured with height dimension of 20 mm and diameter of 10 mm. After that, the specimen was friction tested using the pin on disc method. The highest coefficient of friction was the specimen without electroless coating with the addition of 2 wt% Mg of 0.634. The more mass fraction of sea sand, the higher the porosity, and the lower the density. An electroless coating process can be carried out on reinforcing particles. This study aims to determine the effect of addition of Mg and treatment of reinforcing particles on the Al6061-Sea sand composite on the coefficient of friction and wear rate. The coefficient of friction, the specimen density increased, the porosity and the wear rate, decreased. This occurred because the reinforcement particle size of sea sand bonded strongly to aluminium matrix. The highest coefficient of friction was the electroless coating with the addition of 2 wt% Mg of sea sand, which was 0.646.
Esnek Çalışma’nın Kadınların İşgücü Piyasasına Katılımına Etkileri
Authors: Kalaycı Cemalettin , Yıldırım Fatma
Published: August 2024

Küreselleşme süreciyle birlikte hız kazanan teknolojik ve ekonomik gelişmeler üretim tekniğini, üretim yerini, iş yapma biçimlerini, işyeri büyüklüğü etkilemektedir. Tüm bu gelişmeler neticesinde ortaya çıkan esneklik yaklaşımı işgücü piyasasında yapısal değişikliklere neden olmaktadır. İşgücü piyasalarında meydana gelen dönüşümün bir sonucu olarak ortaya çıkan esnek çalışma, kadınların çalışma hayatında karşılaştığı engelleri aşmasında ve iş-aile yaşamının uyumlaştırılmasında bir çıkış kapısı olarak değerlendirilmektedir. Ülkeden ülkeye farklılık göstermekle birlikte, esnek çalışma uygulamalarını kadınlar erkeklere oranla nispeten daha çok tercih etmektedirler. 2022 yılında OECD ortalaması bakımından geçici çalışan kadınların oranı (%12,5) geçici çalışan erkeklerin oranından (%10,5), kadın kısmi süreli istihdam oranı (%24) ise erkek kısmi süreli istihdam oranından (%9,6) fazladır. Esnek çalışmanın kadınlar için tam günlü iş bulamamaya karşın işsiz kalmama, ailevi sorumluluklarını yerine getirebilme serbestliği sağladığı için iş-yaşam dengesini kurabilme ve artan ekonomik koşullar karşısında aile bütçesine katkı sağlama avantajı tanısa da iş güvencesinden yoksunluk, düşük ücretle istihdam edilme ve koruyucu mevzuattan yararlanamama gibi dezavantajları da bulunmaktadır. Bu kapsamda standart istihdam biçimlerinde olduğu gibi esnek çalışma uygulamalarında da koruyucu yasal mevzuatlara ihtiyaç bulunmaktadır.
Effect to Goat Manure and Banana Hump POC on Growth and Yield of Pagoda Mustard (Brassica nanirosa L.)
Authors: Miftakhurrohmat A , Fitria Aulia Nahdhia
Published: August 2024

The aim of the study was to determine the effect of growth and yield of Pagoda mustard greens (brassica nanirosa l.) on the administration of POC banana hump and goat manure, conducted in Ketimang Village, Wonoayu District, Sidoarjo Regency and follow-up observations were carried out at the Agrotechnology Laboratory of Muhammadiyah University of Sidoarjo from February to April. The study used a factorial randomized block design (RAK) with two factors and was repeated 3 times. The first factor is the dose of goat manure planting media consisting of 0ton/Ha, 20ton/Ha, and 40ton/Ha. The second factor was the dose of POC banana hump which consisted of 0ml/l water, 50ml/l water, and 100ml/l water. The variables observed were plant height, stem diameter, number of leaves, leaf area, wet weight, dry weight, and harvest index. The results showed that there was a significant interaction between goat manure at a dose of 40ton/ha and POC Bonggol Banana at a dose of 100ml/l water on the number of leaves at 35 DAP. Treatment of goat manure at a dose of 40ton/ha resulted in growth and yield production on plant height variables at the age of 42 DAP, 49 DAP, stem diameter, wet weight, and plant dry weight.
Effects of Photobiomodulation and Bethanechol Chloride Treatment on Salivary Composition and Flow Rate in Head and Neck Cancer Patients Undergoing Radiotherapy
Authors: Schepanski Natalia , Liebl Bruna Melo Silva , Mendes Reila Taina , Costa Floriatan Santos , Amaral Clarice D. B. , Machado Raquel C. , Nogueira Ana Rita A. , Sassi Laurindo Moacir , Araujo Melissa Rodrigues
Published: August 2024

Objective
To evaluate the efficacy of photobiomodulation therapy (PBMT) and bethanechol chloride (BC) on the quantity and quality of saliva in patients undergoing radiotherapy (RT) for head and neck cancer.
Methods
Saliva samples were collected from patients before and after RT, who were treated with PBMT or BC. Clinical parameters, including salivary flow rate (SFR), pH, xerostomia, and concentrations of macro and microelements in saliva, were assessed. Data were compared and analyzed using a self-organizing map.
Results
No significant changes were observed in SFR, pH, and xerostomia pre- and post-RT in both the PBMT and BC-treated groups. However, there was an increase in Cr levels in the BC group and a reduction in P levels in the PBMT group.
Conclusion
The results suggest that both PBMT and BC treatments can effectively mitigate the impacts of RT. The quality and quantity of saliva were maintained, potentially contributing to the preservation of patients' quality of life.
Formic acid dehydrogenation using Ruthenium-POP pincer complexes in ionic liquids
Authors: Nikol Alexander Tobias , Rabell Brenda , Larsen René Wugt , Nielsen Martin
Published: August 2024

Formic acid is one of the most promising candidates for the long-term storage of hydrogen in liquid form. Herein, we present a new collection of ruthenium pincer complexes of the general formula [RuHCl(POP)(PPh3)] using commercially available or easy-to-synthesize tridentate xantphos-type POP pincer ligands. We applied these complexes in the dehydrogenation of formic acid to CO2 and H2 using the ionic liquid BMIM OAc as solvent under reflux-free, mild conditions. The best performing catalyst with respect to maximum turnover frequency, the literature-known complex [RuHCl(xantphos)(PPh3)], produced a turnover frequency of 4525 h− 1 with 74% conversion after 10 minutes at 90°C and complete conversion (> 98%) occurring within 3 hours. On the other hand, the best overall performing catalyst, the novel complex [RuHCl(iPr-dbfphos)(PPh3)], facilitated full conversion within 1 hour leading to an overall turnover frequency of 1009 h− 1. Moreover, catalytic activity was observed at temperatures as low as 60°C. Finally, Arrhenius plots suggest activation energies between 50.4 and 63.7 kJ mol− 1. Only CO2 and H2 are observed in the gas phase, with no CO detected.
A Comparative Study of Deformation in Hexagonal and Star-Shaped Implant Screwdriver Heads
Authors: Nourizadeh Amin , Ghasemi Shima , Shafiee Elnaz , JafarZadeh Sevda , Bakhtiari Fatemeh
Published: August 2024

Background: The study compared the deformation characteristics of hexagonal and star-shaped implant screwdriver heads after multiple opening and closing cycles.
Methods: In this in vitro experimental study, abutments were placed on two implant systems mounted in die stone and torqued to 25 N/cm according to the manufacturer's recommendations, using 12 screwdrivers (n=six for each implant). The screwdriver heads underwent examination under a stereomicroscope at 50x magnification. Subsequently, the outline and deformation of the screwdriver head after 0, 50, 100, 200, and 300 opening and closing cycles were analyzed using AutoCAD software. The changes in the surface area of hexagonal and star-shaped driver heads after different cycles were statistically evaluated using SPSS 24 (α=0.05).
Results: The investigation revealed a reduction in the surface area of both hexagonal and star-shaped driver heads with an increase in the frequency of cycles. Notably, following all cycles, except 0-50 and 50-100, the alterations in the surface area of the star-shaped driver head were significantly greater than those observed in the hexagonal driver head (P<0.001).
Conclusion: The study shows that the star-shaped driver head deformed more than the hexagonal one, especially in cycles exceeding 100.
Enhancing therapeutic decisions during robot-assisted gait therapy: Current challenges and development of a novel app-based therapy protocol to address them
Authors: Dellen Florian van , Aurich Tabea , Labruyère Rob
Published: August 2024

Background
Therapists' decisions on influencing patient behavior during robot-assisted gait therapy directly impact clinical practice and, thus, therapeutic efficacy. These manipulations include device parameter adjustments and direct interactions with patients. Little research has been done on how therapists accomplish this task, and knowledge about what constitutes good decisions is scarce. The scarce knowledge is partly due to missing tools to document these decisions. Understanding how therapists assess behavior, manipulate patient behavior, and re-assess behavior for potential improvement could lead to better therapy outcomes.
Methods
We developed a novel mobile application to document therapeutic decisions based on expert knowledge and literature findings. Each documented manipulation consisted of three parts: The evaluation of the patient behavior (goal-oriented and compensatory), the manipulation by the therapist (direct interaction or device interaction), and the re-evaluation of the behavior concerning the consequences of this manipulation. The resulting application was pilot-tested with 10 patients in 5 sessions and 7 therapists in a real-world clinical setting.
Results
Therapists selected more than two therapy goals per session for 50% of the training sessions. The results show that 92% of the manipulations were direct interactions and 8% device interactions. Sixteen percent of the direct interactions targeted the selected goal and 43% compensatory movements. The type of manipulation had a statistically significant impact on the rate of improvement at re-evaluation, with direct interactions targeting compensatory movements having the best rate of improvement (48%) and the parameter adjustments having the lowest rate of improvement (25%).
Discussion
The app developed is a novel approach to documenting therapists' decisions. The data collected in the pilot study revealed several challenges in the decision-making process that therapists can currently only address based on their experience, including goal structure, the relative importance of goal-directed movements versus compensatory patterns, and the type of manipulation taken. Quantitative data provided by the app has the potential to objectify and improve these decisions and could support a transfer of successful treatment approaches between therapists and clinics.
Clinical and radiographic findings of 125 cases with amelogenesis imperfecta
Authors: Koruyucu Mine , Ozcan Hazal , Kasimoglu Yelda , Tuna Elif , Seymen Figen
Published: August 2024

Objectives: The aim of this study was to determine the clinical and radiographic intraoral findings of patients with different types of amelogenesis imperfecta (AI).
Materials and methods: One hundred twenty-five individuals belonging to 103 Turkish families with AI who were admitted to İstanbul University Faculty of Dentistry Department of Pedodontics were examined between 2006 and 2018. Intraoral and extraoral examinations, intraoral radiographs and pedigrees of the cases were examined and genetic analyses were planned. All datas was included in the SPSS database and analyzed using the Chi-Square and Mann-Whitney U tests.
Results: The frequency of clinical and radiographic findings in different AI types was not statistically significant (p>0.05). Gene mutation was detected in different types of candidate genes in 32 families, While the presence of gene mutation was found to be statistically significant in different AI types (p<0.05), no significant difference was found between genetic mutations and consanguineous marriage (p>0.05).
Conclusions: AI is a complicated dental anomaly requiring long-term follow-up. Familial evaluation of the cases and complete radiographic and clinical controls are important for diagnosis and treatment.
Clinical revelance: This study emphasizes the importance of comprehensive and continuous assessment of patients with AI. By detailing intraoral and radiographic findings and identifying genetic mutations in various AI types, it aids clinicians in enhancing diagnostic accuracy and customizing treatment plans.
Efficacy and safety of upadacitinib, a selective JAK-1 inhibitor in treatment of ankylosing spondylitis: a meta-analysis
Authors: Yao Qi , Zhu Yixuan , Ma Yanling , Pu Yanfang , Yang Xueting , Zhang Zhiqing
Published: August 2024

Objective: To systemically evaluate efficacy and safety of upadacitinib (UPA), a selective inhibitor of Janus kinase 1 (JAK1) in treatment of ankylosing spondylitis (AS).
Methods: PubMed, Embase, Elsevier, Springer, Google Scholar, Cochrane Library, China national knowledge infrastructure (CNKI), and other databases were used to retrieve literatures of randomized controlled trials (RCTs) of UPA treating AS until February 2024. After that, the data were extracted and the Revman 5.4 software was used to conduct a meta-analysis.
Results: A total of 6 articles and 1653 patients (920 in an UPA group (15 mg, q.d) and 733 in a placebo group) were selected in this study. Respectively, the UPA treatment significantly increased numbers of the AS patients with 40%, 20%, and partial remission (PR) improvement in assessment of spondylo arthritis international society (ASAS) (ASAS 40: 95%CI: 2.41 - 4.3, p < 0.00001; ASAS 20: 95%CI: 2.12 - 3.62, p< 0.00001; ASAS PR: 95%CI: 2.81 - 7.48, p < 0.00001), Bath ankylosing spondylitis disease activity index (BASDAI50) (95%CI: 2.28 ～ 4.10, p < 0.00001), quality of life (95%CI: 2.06 ～ 3.17, p < 0.00001), AS disease activity score low disease activity (ASDAS LDA) (95%CI: 3.07～9.96, p < 0.00001), ASDAS inactive disease (ID) (95%CI: 2.03 ～ 17.22, p = 0.001), short-form 36 physical component summary (SF-36PCS) (95%CI: 1.53 ～2.81, p < 0.00001), and markedly reduced ASDAS C-reactive protein (CRP) (95%CI: -1.22 ～ -0.42, p < 0.0001), total back pain score (95%CI: -2.01 ～ -0.51, p = 0.001), nighttime back pain score (95%CI: -1.96 ～ -0.54, p = 0.0006), spondylo arthritis research consortium of Canada magnetic resonance imaging (SPARCC MRI) spine score (95%CI: -7.78 - -3.50, p < 0.00001) and SPARCC MRI sacroiliac joint score (95%CI: -5.99 - -3.09, p < 0.00001), Bath ankylosing spondylitis function index (BASFI) score (95%CI: -1.45 ～ -0.81, p < 0.00001), Maastricht ankylosing spondylitis enthesitis score (MASES) (95%CI: -2.34～-0.35, p = 0.008). Except for neutropenia (95%CI: 1.25 ～ 15.60, p = 0.02), no other obvious adverse effects (AEs) were found after the UPA treatment.
Conclusions: UPA exerts a significant therapeutic effect in the patients with AS, and it has relative higher safety.
A Mathematical Model Simulating the Adaptive Immune Response in Various Vaccines and Vaccination Strategies
Authors: Xu Zhaobin , Song Jian , Zhang Hongmei , Wei Zhenlin , Wei Dongqing , Yang Guangyu , Demongeot Jacques , Zeng Qiangcheng
Published: August 2024

Vaccination has been widely recognized as an effective measure for preventing infectious diseases. To facilitate quantitative research into the activation of adaptive immune responses in the human body by vaccines, it is important to develop an appropriate mathematical model, which can provide valuable guidance for vaccine development. In this study, we constructed a novel mathematical model to simulate the dynamics of antibody levels following vaccination, based on principles from immunology. Our model offers a concise and accurate representation of the kinetics of antibody response. We conducted a comparative analysis of antibody dynamics within the body after administering several common vaccines, including traditional inactivated vaccines, mRNA vaccines, and future attenuated vaccines based on defective interfering viral particles (DVG). Our findings suggest that booster shots play a crucial role in enhancing IgG antibody levels, and we provide a detailed discussion on the advantages and disadvantages of different vaccine types. From a mathematical standpoint, our model proposes four essential approaches to guide vaccine design: enhancing antigenic T-cell immunogenicity, directing the production of high-affinity antibodies, reducing the rate of IgG decay, and lowering the peak level of vaccine antigen-antibody complexes. Our study contributes to the understanding of vaccine design and its application by explaining various phenomena and providing guidance in comprehending the interactions between antibodies and antigens during the immune process.
Effects of different glomerular filtration rates on new-one heart failurein a community-based population with type 2 diabetes
Authors: Sang Dasen , Tao Jie , Song Wanqing , Zhang Qi , Wu Shouling , Geng Wei
Published: August 2024

Aims
This study aimed to investigate the impact of different estimated glomerular filtration rate (eGFR) values like cystatin C-based eGFR (eGFRcys), creatinine-based eGFR (eGFRcr), and their difference (eGFRdiff; eGFRcys -eGFRcr), on the incidence of heart failure (HF) in patients with type 2 diabetes(T2D).
Methods
Being a prospective cohort study, it included 7,967 patients with T2D who underwent serum creatinine and cystatin C tests as part of the Kailuan Group’s 6th annual health examination (2016). Subsequently, eGFRcys, eGFRcr, and eGFRdiff were calculated. Patients were categorized into three groups: negative (<-15 mL/min/1.73 m2), midrange (-15 to 15 mL/min/1.73 m2), and positive (> 15 mL/min/1.73 m2) eGFRdiff groups, respectively. Furthermore, the relationship between the various eGFR measurements and new-onset HF were studied using Cox proportional hazards regression, and the potential improvement in predictive capability was evaluated by adding these eGFR metrics to established HF risk models.
Results
Among 7967 participants with mean age of 60.51 years, there were 20.92% women and 79.08% men. At baseline, eGFRcys and eGFRcr values differed by more than 15 mL/min/1.73m2 in 41.3% of participants. During a median follow-up period of 3.76 years, there were 172 (2.16%) new HF cases and 517 (6.49%) all-cause deaths. The cumulative incidence of HF in the midrange, negative, and positive eGFRdiff groups was 1.74%, 4.10%, and 0.61%, respectively (p < 0.001). In multivariable adjusted models, participants in the negative eGFRdiff group had higher risk of HF compared with the midrange eGFRdiff group (HR, 2.15; 95% CI, 1.57–2.94). Conversely, participants in the positive eGFRdiff group had lower risk for HF (HR, 0.40; 95% CI, 0.17–0.93). And each 15 mL/min/ 1.73 m2 higher eGFRdiff was associated with 34% (HR, 0.66; 95% CI, 0.58 − 0.47)lower risk of incident HF. The predictive capacity for HF risk in diabetic individuals was enhanced by adding eGFRcys or eGFRdiff to established HF risk models, with eGFRcys showing more significant additional predictive value.
Conclusion
These findings suggest that large differences between eGFRcys and eGFRcr were common in community-based population with T2D. Different eGFR metrics can independently predict HF incidence in patients with T2D. Additionally, metrics like eGFRcys and eGFRdiff provide significant predictive value for HF risks beyond traditional risk factors, with eGFRcys showing more pronounced benefits in such cases.
Asymptomatic giant epiglottic cyst causing an unexpectedly difficult airway: A case report
Authors: Han Shunyu , Yang Guoyan
Published: August 2024

Background: The presence of giant epiglottic cysts can lead to throat discomfort, foreign body sensation within the throat and respiratory distress. However, asymptomatic sufferers who remain undiagnosed may additionally face demanding situations in airway control during anesthesia emergencies. In intense instances, a tracheotomy may be required.
Case presentation: A 61-year-old male, recognized with heel spur, underwent optionally available arthroscopic osteotomy. However, ventilation was difficult during anesthesia and impossible post-laryngeal mask insertion. Video laryngoscopy revealed a giant epiglottic cyst. Tracheal intubation under video laryngoscopy was eventually successful.
Conclusion: In asymptomatic giant epiglottic cysts, preoperative anaesthetic assessment must be comprehensive, especially regarding the risk of a difficult airway. If the epiglottic cyst is discovered during anaesthesia, a difficult airway should be managed appropriately. Prompt use of video laryngoscopy in difficult airways increases successful intubation probability and appropriate ventilation tools may aid ventilation in cases of failed intubation. However, calling for help in all cases remains paramount.
Aptamer-modified GSH-sensitive honokiol polyprodrug nanoparticles for ovarian cancer-specific targeting therapy
Authors: Guo Chunhua , Cheng Xiaowei , Yang Yuxing , Wang Lijuan , Wang Wenfang , Shao Liping
Published: August 2024

Background
Ovarian cancer is a major threat to women's lives. Chinese medicine honokiol (HK) is a polyphenol isolated from Magnolia, which can effectively suppress the growth of ovarian cancer. However, low water solubility and lack of tumor-targeting ability have greatly hindered the clinical application of HK.
Results
Herein, a glutathione (GSH) sensitive HK polyprodrug was prepared by using HK as the backbone. Then, an EpCAM-specific aptamer and poly(ethylene glycol) (PEG) were conjugated to HK polyprodrug, and the obtained polyprodrug was assembled into nanoparticles in water. The HK polyprodrug-formed nanoparticles achieved high drug loading and GSH-responsiveness drug release. Moreover, after optimization, HK polyprodrug nanoparticles (A/P-PHK NP40) formed by aptamer-modified and PEG-modified prodrug at feed molar ratio at 2: 3 had the highest ability to target EpCAM overexpression ovarian cancer cells. A/P-PHK NP40 also exhibited a higher cell growth inhibition effect in ovarian cancer cells than free HK and control HK nanoparticles.
Conclusion
All in all, this work reported a novel strategy for HK delivery based on microenvironment responsiveness polyprodrug, which provided a potential method for ovarian cancer targeting therapy.
In vivo aphrodisiac efficacy of aqueous and hydroalcoholic extracts of the leaf and root bark of Citropsis articulata in male Wistar rats
Authors: Amaza Anyase Ronald , Amutuhaire Treasure Angie , Tusiimire Jonans , Amito Vivian Sharon , Ajayi Clement Olusoji , Angupale Jimmy Ronald , Abdelgadir Abdelgadir Alamin , Godwin Anywar , Ogwang Patrick Engeu
Published: August 2024

Background
The African cherry orange tree Citropsis articulata Swingle & Kellerman (family Rutaceae) is traditionally used to manage erectile dysfunction. This study aimed to determine the aphrodisiac activity of C. articulata leaves and root bark in male Wistar rats.
Methods
Aqueous and hydroalcoholic extracts of leaves and root bark were prepared via decoction and soxhlation, respectively. Extracts were administered to the animals at three dose levels, i.e., 100, 500 and 1000 mg/kg. Six male animals (aged 8–12 weeks, weighing 140–200 g) were used in each of the groups. Three animals per group (group B), unlike those immediately sacrificed at the end of 28 days (group A), were left for an extra 14 days without dosing to look out for delayed or sustained efficacy signs. Male sexual behavior, including attraction towards the female, penile erection, mount frequency, and mount latency, was monitored on days 0, 3, 7, 14, 21, 28, 35 and 42. At the end of both 28 days and the extra 14 days, the animals were humanely sacrificed via anesthesia with halothane, and their blood was collected for testosterone level analysis, while the sexual organs harvested were assessed grossly and histologically.
Results
Citropsis articulata root bark and leaves increased the attraction towards the female, penile erection, and mount frequency while lowering the mount latency. The plant extracts also increased testosterone levels after 28 days of daily extract administration but greatly lowered the testosterone levels in the animals that were left for an extra 14 days without dosing. Even histologically, there was the first evidence of very active spermatogenesis, which disappeared when the administration of the extract ceased. The administration of C. articulata leaf decoction at a dose of 500 mg/kg significantly increased the testosterone level (14.50 ± 2.53 ng/ml) compared with that of the positive control (4.00 ± 2.70 ng/ml), with a p-value of 0.021 (confidence interval: -19.45 to -1.533).
Conclusion
This study revealed that both the root bark and leaf of Citropsis articulata have aphrodisiac efficacy in male Wistar rats in vitro.
PLK1 overexpression suppresses homologous recombination and confers cellular sensitivity to PARP inhibition
Authors: Pae Sookhee , Sedukhina Anna S , Sugiyama Runa , Atanacio Sarah J , Ohara Tatsuru , Ishii Masato , Minagawa Kimino , Akichjev Romaan , Go Fumie , Chandankeri Zayan , Janjetic Zoran M M , Sato Eri , Yamaura Ayako , Maeda Ichiro , Takeuchi Osamu , Suzuki Nao , Yudo Kazuo , Bernal Juan A , Sato Ko
Published: August 2024

The overexpression of Polo-like kinase 1 (PLK1) is linked to poor clinical outcomes in various malignancies, making it an attractive target for anticancer therapies. Although recent studies suggest PLK1's involvement in homologous recombination (HR), the impact of its overexpression on HR remains unclear. We investigated the effect of PLK1 overexpression on HR using bioinformatics and experimental approaches. Analyzing The Cancer Genome Atlas (TCGA) and Cancer Cell Line Encyclopedia (CCLE) datasets with the Homologous Recombination Deficiency (HRD) score, we found a positive correlation between PLK1 expression and HRD score, indicating that increased PLK1 expression suppresses HR. To validate these findings, we performed cell line-based experiments, demonstrating that PLK1 overexpression attenuates RAD51 focus formation and HR, as measured by ASHRA in U2OS cells. Given that HR-deficient cells display hypersensitivity to PARP inhibitors, we further confirmed that PLK1 overexpression increases sensitivity to PARP inhibitors, both in CCLE dataset analysis and experiments using U2OS cells. Additionally, analysis of clinical ovarian cancer samples revealed that higher PLK1 expression correlates with increased sensitivity to PARP inhibitors. Our results suggest that PLK1 overexpression suppresses homologous recombination, leading to enhanced sensitivity to PARP inhibition, presenting a potential therapeutic strategy for targeting cancers with overexpression of PLK1.
Facile quantitative diagnostic testing for neutralizing antibodies against chikungunya virus
Authors: Lin Hui-Chung , Chang Shu-Fen , Su Chien-Ling , Hu Huai-Chin , Chiao Der-Jiang , Hsu Yu-Lin , Lu Hsuan-ying , Lin Chang-Chi , Shu Pei-Yun , Kuo Szu-Cheng
Published: August 2024

Background:
Viral neutralization (NT) assays can be used to determine the immune status of patients or assess the potency of candidate vaccines or therapeutic monoclonal antibodies (mAbs). Focus reduction neutralization test (FRNT) is a conventional neutralization test (cVNT) with superior specificity for measurement of neutralizing antibodies against a specific virus. Unfortunately, the application of FRNT to the chikungunya virus (CHIKV) involves a highly pathogenic bio-agent requiring biosafety level 3 (BSL3) facilities, which inevitably imposes low throughput and long turnaround times. In this study, we evaluated a safe surrogate virus neutralization test (sVNT) that uses novel CHIKV replicon particles (VRPs) expressing eGFP and luciferase (Luc) to enable the rapid detection and quantification of neutralizing activity in clinical human serum samples.
Methods:
This unmatched case-control validation study used serum samples from laboratory-confirmed cases of CHIKV (n = 19), dengue virus (DENV; n = 9), Japanese encephalitis virus (JEV; n = 5), and normal individuals (n = 20). We evaluated the effectiveness of VNT based on mosquito cell-derived CHIK VRPs (mos-CHIK VRPs) in the detection of (eGFP) and quantification of (Luc) NT activity in terms of specificity, sensitivity and reproducibility. We conducted correlation analysis between the proposed rapid method (20 hours) versus FRNT assay (72 hours). We also investigated the correlation between sVNT and cVNT in NT titrations in terms of Pearson’s correlation coefficient (r) and sigmoidal curve fitting.
Results:
In NT screening assays, sVNT-eGFP screening achieved sensitivity and specificity of 100%. We obtained a Pearson’s correlation coefficient of 0.83 for NT50 values between sVNT-Luc and cVNT.
Conclusions:
Facile VRP-based sVNT within 24 hours proved highly reliable in the identification and quantification of neutralizing activity against CHIKV in clinical serum samples.
The Sliding Flux Ramp Demodulation Algorithm with High Sampling Rate in Microwave SQUID Multiplexer
Authors: Liao Guofu , Liu Congzhan , Li Zhengwei , Yan Daikang , Ren Xiangxiang , Zhang Yongjie , Zhang Laiyu , Xu Yu , Shu Shibo , Gao He , Zhang Yifei , Lu Xuefeng , Li Xufang , Xu He , Wu Di
Published: August 2024

Microwave SQUID Multiplexing ($\mu$MUX) is a widely used technique in the low temperature detectors community as it offers high capacity of reading out large scale Transition-Edge Sensor (TES) arrays. In this paper, we propose a Sliding Flux Ramp Demodulation (SFRD) algorithm for $\mu$MUX readout system. It can achieve a sampling rate in the order of MHz while maintaining a multiplexing ratio about one thousand. Advancing of this large array readout technique makes it possible to observe scientific objects with improved time resolution and event count rate. This will be highly helpful for TES calorimeters in X-ray applications, such as X-ray astrophysics missions.