EXPLORING THE IMPACT OF THE MICRO-RNA GENETIC VARIANT RS20541 ON GLIOBLASTOMA AND ITS IMPLICATIONS ACROSS MULTIPLE CANCER TYPES: A META-ANALYSIS
Authors: Shama Zahra  , Muskan Fatima  , Aisha Hamid  , Hafiza Sarwat Noor  , Muhammad Zain  , Iftikhar Ahmed  , Aqsa Khalid  , Zeenat Mahmood  , Sumaira Younus  , Syed Hamza Abbas  , Haseeb Nisar  , Shama Abid  , Yumna Hidayat  
Published: February 2025

Through a thorough Meta-analysis, this work explores the relationship between the microRNA gene variant rs20541 and Glioblastoma, as well as its possible consequences for other cancer types.One type of cancer reported to be susceptible to single nucleotide polymorphisms (SNPs) is glioblastoma. It's interesting to note that a frequently occurring SNP in microRNA has been linked to carcinogenesis in a variety of cancer types. The purpose of this study is to investigate the unique effects of rs20541 on glioblastoma as well as any possible wider implications for this gene in relation to other malignancies. The research also emphasizes how this immunoregulatory cytokine interleukin-13 (IL13) affects tumor immunosurveillance. It is known that IL13 has a major impact on carcinogenesis, indicating that it plays a role in the intricate processes that underlie the onset and spread of cancer.Through clarifying the connection with the IL13 microRNA genetic variation and cancer, this work aims to improve our knowledge of the molecular processes underlying the advancement of cancer and offer insights into possible medical treatment pathways.Inconclusive results have been found in several research examining the impact of IL13 rs20541 polymorphisms affecting cancer risk. Given this, the current work aims to elucidate this relationship using a thorough meta-analysis.For the purpose of both quantitative and qualitative information synthesis, a total of twenty studies have been included, following the PRISMA standards for data retrieval.A meta-analysis presents a useful chance to synthesize and evaluate data from various studies, offering a more thorough knowledge of the association among IL13 rs20541 polymorphism and cancer risk, especially in light of the conflicting results from earlier research. This study attempts to overcome the constraints associated with individual investigations and provide strong insights into the possible influence of this gene polymorphism on cancer susceptibility by using a rigorous technique and following established principles. The goal of this work is to add to the pool of knowledge already accessible about the involvement of IL13 rs20541 polymorphisms towards the development of cancer through a systematic examination and synthesis of relevant evidence. In the end, the results of this meta-analysis might affect risk evaluation and screening, as well as possibly guide individualized preventive and curative plans. Meta-analysis was performed on the SNP rs20541 in different ethnicities of Asian and European populations by using SPSS and STATA. According to our meta-analysis, the IL13 rs20541 polymorphism increases a person's risk of developing cancer, particularly gliomas. Our meta-analysis suggests that the variant allele present(A) in IL13 rs20541 polymorphism is highly significant in Asian population and European population as depicted by the P-values. It is also significantly associated or present in Gliomas as compared with other cancer.  Further validation of our findings would need larger, future investigations using well-matched groups and standardized, impartial, heterogeneous patients.