bluuebunny/crossref_metadata_2025 huggingface dataset:
RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF TELMISARTAN IN BULK AND TABLET DOSAGE FORM
Authors: Bhadoriya Upendra , Dhaked Hemant , Danodia Abhinandan Kumar
Published: July 2018

A simple, sensitive, precise and specific reverse phase high performance liquid chromatographic method was developed and validated for the determination of Telmisartan in bulk and tablet dosage forms. It was found that the excipient in the tablet dosage forms does not interfere in the quantification of active drug by proposed method. The HPLC separation was carried out by reverse phase chromatography on RP18, column (250×4.6mm) with a mobile phase composed of 0.025M potassium dihydrogen phosphate : acetonitrile : methanol (45:50:5) at a flow rate of 1ml/min. The detection was monitored at 216 nm. The calibration curve for Telmisartan was linear from 100 to 500 ng/ml. The interday and intraday precision was found to be within limits. LOD and LOQ for Telmisartan were found to be 27 ng/ml and 83 ng/ml. Accuracy and reproducibility were also found within range. The proposed method has adequate sensitivity, reproducibility and specificity for the determination of Telmisartan in bulk and its tablet dosage forms.
FORMULATION AND EVALUATION OF NANOSUSPENSION OF ROSUVASTATIN CALCIUM
Authors: Raturi Ankita , Bhatt Ganesh , Kothiyal Preeti
Published: July 2018

Poor water solubility and slow dissolution rate are issues for majority of upcoming and existing biologically active compounds. The aim of present work was to increase the dissolution rate of Rosuvastatin Calcium, a poorly water soluble drug and hence improve its oral bioavailability by Nanosuspension technology. Nanosuspension is new carrier free colloidal drug delivery system with nano sized particles below 1000 nm, and considered as a great drug delivery technique to enhance the drug dissolution and solubility. In the present work Nanosuspension is made by nanoprecipitation technique in the presence of sodium lauryl sulfate as surfactant and PVPK-30 as stabilizer. Prepared Nanosuspension was evaluated for its particle size study, in vitro dissolution study and characterized by Screening Electron microscopy (SEM).

Different concentrations of sodium lauryl sulphate (SLS) and PVPK-30 were evaluated. All formulations were in the nano size and showed marked improvement in dissolution and solubility compared to pure drug of micron size. Finally it was concluded that formulating poorly soluble drugs in the form of Nanosuspension would be a promising approach in delivery of poor water soluble drugs by oral route in a simple and effective way.
SIMULTANEOUS UV SPECTROPHOTOMETRIC METHODS FOR ESTIMATION OF CEFADROXIL AND PROBENECID IN TABLET DOSAGE FORM
Authors: Jain Mayur S. , Bavaskar Sunil R. , Barhate Shashikant D. , Fegade Jintendra D.
Published: July 2018

Two methods for simultaneous estimation of Cefadroxil and Probenecid in combined tablet dosage form have been developed. The first UV spectrophotometric method was a determination using the simultaneous equation method at 233 nm and 247 nm. The second UV spectrophotometric method is the Q – analysis (absorption ratio) method, which involves the formation of absorbance equation at 242 nm (Isobestic point) and at 247 nm the maximum absorption of Probenecid . The linearity ranges for Cefadroxil and Probenecid both were 10-60μg/ml respectively. The accuracy of the methods was assessed by recovery studies was found to be 99.43±0.75 and 99.69±0.40 for simultaneous equation method and 99.23±0.34 and 99.56±0.16 for absorption ratio method for Cefadroxil and Probenecid respectively. These methods are simple, accurate and rapid; those require no preliminary separation and can therefore be used for routine analysis of both drugs in quality control laboratories.
REGULATORY PERSPECTIVES OF PHARMACEUTICAL PRODUCTS IN GHANA
Authors: G. Raja Mohan Reddy , Venkatesh M. P. , J. Achin , T.M. Pramod Kumar
Published: July 2018

Drug Registration is a procedure of expertise of pharmaceutical product quality, efficacy and safety by the Regulatory Authority. The emergence of various formats has enabled the manufacturers of the drug to easily gain access into various markets and thus was able to place their products into the market. The choice of Ghana as one of the destinations for the market of the Drug products ensures the manufacturer a good market value. Ghana is considered as one of the growing pharmaceutical market in east Africa. Of late, generic drugs are holding a major stake in the pharmaceutical market and are gaining more and more confidence in the usage. Majority of medicines in the Ghana are generic drugs which are considered as value for the money and affordable. With Ghana Regulatory Authority is the Food and Drugs Board, which takes decision to register the product and issues Registration Certificate. This study mainly focuses on the regulatory environment, registration process involved and the regulatory requirements that are applicable for the generic drug products in Ghana.
EXCLUSIVITY STRATEGIES OF INNOVATOR DRUG DEVELOPERS
Authors: K. Chaitanya Prasad , M. Prabodh , S. Ashish , R. Suthakaran , M. Naveen Reddy , M. Ravindra Reddy
Published: July 2018

Pharmaceutical drug development had become very costly and time consuming. There is an estimate that a drug from molecular development to marketing approvals cost $800 Millions. Drug approval process is time consuming process most companies loss their patent exclusivity before drug gets marketing approvals. To prevent innovators from monetary losses occurred in drug development and to encourage innovation US FDA and EMEA introduced exclusivities under various categories.  Within the period of drug exclusivity no application is accepted either ANDA or 505 (b) (2).
A SNAP-SHOT OF FIRST-LINE ART TREATMENT FAILURE CASES FROM MPUMALANGA PROVINCE ON THE DECENTRALISED PHARMACOVIGILANCE PROGRAMME DATABASE
Authors: Dheda Mukesh , Futshane B. , Kambafwile H. , Fomundam H.
Published: July 2018

The increase in ART use comes with the inevitable increase in cases of ART treatment failure, especially that patients are living longer on ART. The main objective of this short study was to conduct an interim review of the Pharmacovigilance database at the National Pharmacovigilance Centre of South Africa in order to profile cases of treatment failure with first-line antiretroviral therapy among HIV-infected patients in Mpumalanga Province. From 2851 ADR reports, 853 were reported for male patients, 1699 females and 299 had no gender reported. A total of 271 patients were diagnosed with treatment failure. 170 of these were female, 78 male and for 23 of the reports, gender was unreported. The mean age of the patients who were reported to have treatment failure was 36 years. The highest number of treatment failure was reported from the age group 31 - 40 years with the majority being females. A strong correlation was observed between female sex and treatment failure. The South African National Pharmacovigilance Centre decentralized Pharmacovigilance database is a useful tool that can be used to consistently monitor and document ART treatment failures.
FACTS ON DRUG REGULATIONS
Authors: Gupta Rajkumar
Published: July 2018

The pharmaceutical products are very much driven by the drug regulation imposed by ministry of health in individual countries. The basic facts on regulations is that they are mandatory and noncompliant are punishable under the law. Further, compliance is not a one time job but it is an exercise to be performed over the life cycle of the drug products. It starts from development of the products and continues till the product is in market. The information, registration, permission and extensions/withdrawals are the primary regulatory requirements for the drug products.

The main focus of drug regulations is to check that safety, quality and efficacy of the drug products over its lifecycle.
REGULATORY ROADMAP FOR NANOTECHNOLOGY BASED MEDICINES
Authors: Limaye Vaidehi , Fortwengel Gerhard , Limaye Dnyanesh
Published: July 2018

Nanotechnology is emerging as one of the key technologies of the 21st century and is expected to enable developments across a wide range of sectors that can benefit citizens. Nanomedicine is an application of nanotechnology in the areas of healthcare, disease diagnosis, treatment and prevention of disease. Nanomedicines pose problem of nanotoxicity related to factors like size, shape, specific surface area, surface morphology, and crystallinity. Currently, nanomedicines are regulated as medicinal products or as medical devices and there is no specific regulatory framework for nanotechnology-based products neither in the EU nor in the USA. This review presents a scheme for classification and regulatory approval process for nanotechnology based medicines.
A STUDY ON HEAMPHILUS INFLUANZAE TYPE B DISEASE CAUSING ANTIGENS: AN APPROACH OF EPITOPE PREDICTION, ANTIGENICITY AND IMMUNOGENICITY PREDICTION
Authors: Fawzi Mukhlif Z. , Suad Ibrahim M. , S. Rekha , Hasan Rgb H. , S. Rao B.
Published: July 2018

Vaccines work by mimicking disease agents and stimulating the immune system which in turn builds a defence mechanism against the disease causing agents. Some of the vaccines contain a part of the disease causing agents which are either weakened or dead. Apart from using vaccines only for viral infections, utilizing the same against Cancers both as therapeutic and preventative has captured huge interest. The use of Cancer vaccines in cancer therapies is called immunotherapy which is done either by specific cancer vaccine or universal cancer vaccine which  contain tumour antigens that stimulate the immune system which in turn initiate various mechanisms that terminate tumour cells and prevents recurrence of these tumours. Hemophilus influanzae is a disease causing virus & here we have done a brief study about the different antigens of the b strain of Haemophilus influenzae and compare them using various bioinformatics tools to get the most effective antigen of the above mentioned strain.
CLINICAL TRIAL IN INDIA: RISE AND FALL
Authors: Kulshreshtha Chitral , Venkatesh M P , Shrisha K , Kumar Pramod T.M. , Kumar Pramod T.M.
Published: July 2018

Fight with the disease is the ever evolving frontier for human beings. Discovery of new drugs and devices throughclinical research are the armory to help in the fight with the affliction of mankind. Clinical trials, test potentialtreatments in human volunteers to see whether they should be approved for wider use in the general population. Atreatment could be a drug, medical device, or biologic, such as a vaccine, blood product, or gene therapy. India stoodas a global hub for clinical trials in past years. Later, the amendments made in Indian regulations paved for the declineof clinical trials. The aim of this article is to provide the details about the Indian clinical trial application filingprocess, the amendments made in its regulations and the challenges faced by Indian clinical trial industry.
THE PATH OF PERSONALIZED MEDICINE: REGULATORY PERSPECTIVE
Authors: Kulshreshtha Chitral , P. Venkatesh M. , T.M. Pramod Kumar
Published: July 2018

Personalized medicine (PM) has become a topic of great interest because of its potential to improve patient care and optimize therapeutic strategy. The way we understand and treat disease is changing rapidly. The traditional form of personalized medicine has been based on the observable manifestations of a disease or treatment, such as a tumour on a mammogram, the appearance of cells under the microscope, etc. But now personalized medicine promises to introduce a new standard of healthcare by using molecular analysis to achieve optimum medical outcomes in the management of a patient’s disease or disease predisposition. PM is providing the right treatment, to the right patient at the right time by using modern biology’s new methods and tools. The objective of this paper is to focus on a realistic scenario for its evolution, and to explore the issues affecting the development and implementation of personalized medicines and various regulatory pathways involved in its regulation. This paper also highlights the roles and applications of personalized medicine. The success of personalized medicine depends on having accurate diagnostic tests that identify patients who can benefit from targeted therapies. The common goal: an integrated policy framework that balances patient, industry and scientific interests without hindering advancement of this tremendously important sector. Through these efforts, we can help ensure that personalized medicine is able to fulfil its promise as rapidly as possible.
DRUG REGULATORY PROCEDURES IN TANZANIA: A GLIMPSE
Authors: Jain Achin , Venkatesh M P M P , Kumar Pramod T.M.
Published: July 2018

In Tanzania, Tanzania Food and Drugs Authority (TFDA), is a regulatory body responsible for controlling the quality,safety and effectiveness of food, drugs, herbal drugs, cosmetics and medical devices. The Authority has been ensuringsafety, efficacy and quality of medicines by quality control tests; in addition to other quality assessment mechanisms.The guidelines laid by TFDA have also emanated from commitment to democracy and gives strong emphasis to thefulfilment of the needs of the less privileged rural population.Tanzania is an emerging market; the pharmaceutical market is valued at over US$250 million, and is growing at anannual rate of around 16.5% and is expected to reach approximately US$550 billion in 2020. Currently, the market ishighly dependent on imports, which account for around 75% of the total pharmaceutical market.The procedures and approval requirements of new drugs, variations, import, export and disposal have been set up bythe TFDA, which help in maintaining quality of the drug products that are imported as well being produced locally
PREPARATION & COMPILATION OF ACTD DOSSIER (PART II QUALITY)
Authors: Gupta Rajkumar M.
Published: July 2018

ACTD is a critical document for drug substance and produces registration in ASEAN region. The document is essentially divided into 4 parts. Each part provides information under specific head. Out of all the parts, the part II is most important. This part not only evaluates technical suitability of the product but also determines the suitability of active drug and Excipients.

The major stress in this part is on formulation, manufacturing, stability and process validation. The information required under this part is suitably detailed in this article.
COMPARISON OF GLOBAL REGULATORY GUIDELINES FOR AVAILABILITY OF DIFFERENT BIOWAIVER PROVISIONS AND APPLICATION REQUIREMENTS OF BIOPHARMACEUTICS CLASSIFICATION SYSTEM (BCS) BASED BIOWAIVER.
Authors: Patel Jimi , Mehta Priti , Kothari Vaishali
Published: July 2018

To waive a complete and systemic Bioequivalence (BE) study, Biowaiver or Request for a Biowaiver is a fast track approach to boost the drug development process. Over the past three-four years the Biowaiver market shows greater number of Biowaiver submissions and the wider use of In-vitro permeability study. Biowaiver is a beneficial approach for getting approval of Abbreviated New Drug Application (ANDA) while, BCS based Biowaiver is the novel approach to gain approval for New Drug Application (NDA) as well as ANDA. A Biopharmaceutics Classification System (BCS) based Biowaiver is an exemption from conducting human bioequivalence studies when active ingredient and dosage form meet criteria of solubility, permeability and dissolution. The Paper covers different kind of Biowaiver approaches and the criteria for the applicability of BCS based Biowaivers in the different geographic scopes with regard to global development strategy. There is a comparison of global guidelines on provisions availability for different types of Biowaiver approaches as well as for requirements of Biowaiver based on BCS. From comparison of different global guidelines it is reviewed that most of the guidance resembles to the USFDA, EU and WHO guidelines because most of the regulatory authorities are following the BCS based Biowaiver concept as one of the three main guidance documents (USFDA, EMA, WHO) or a combination of specific requirements.
REGULATORY REQUIREMENTS FOR DRUG PRODUCTS REGISTRATION IN SOUTH AFRICA
Authors: V. Senthil , Srianitha L. , Baviyapriyadharshini R.
Published: July 2018

The South African Pharmaceutical market is one of the emerging markets in the world and it is important to study on how to register a drug in the promising pharmaceutical market in Africa. The MCC is the regulatory body which deals with the quality, safety and efficacy of the medicines in South African market which regulates by approving the medicines by very specific process which is unique to South African health system. They have a specific type of CTD for Regulatory submissions which is generally well known as ZA CTD. This article provides the insight on the Drug Registration process in South Africa, the details of data to be submitted to the agency and the pathways of registration an applicant can avail, categories a drug can be registered by MCC, Application fees to be paid to the agency on various types of applications are also dealt.
Wyniki produkcyjne i ekonomiczne gospodarstw ogrodniczych
Authors: Komorowska Dorota
Published: July 2018

Celem opracowania jest ocena wyników gospodarowania zasobami produkcyjnymi w gospodarstwach nastawionych na produkcję ogrodniczą na tle wyników ogółu gospodarstw rolnych, które były objęte rachunkowością rolną w systemie FADN w latach 2013-2015. Analizie poddano wyniki produkcyjne i ekonomiczne oraz produktywność i dochodowość zasobów ziemi, pracy i kapitału. Zaprezentowane w opracowaniu wyniki badanych gospodarstw wskazują na znacznie wyższy poziom efektywności produkcyjnej zasobów w gospodarstwach ogrodniczych, zwłaszcza produktywności ziemi, ale także kapitału. Gospodarstwa specjalizujące się w produkcji ogrodniczej uzyskały wyniki ekonomiczne na kilkukrotnie wyższym poziomie niż gospodarstwa ogółem, dlatego przewyższały je bardziej efektywnością ekonomiczną niż produkcyjną, zwłaszcza w gospodarowaniu zasobami ziemi, jak również kapitału. Dopłaty do działalności gospodarstw ogrodniczych nie mają dużego wpływu na poziom dochodów uzyskiwanych przez te gospodarstwa.
Development of Agritourism in the Light of Economics: Case Studies of Italy and Poland
Authors: Kummitha Harshavardhan , Huseynov Raqif , Wojtaszek Michał
Published: July 2018

Recreational activities pertaining to farmlands are receiving increased attention from both research and practice. One of the major reasons for this heightened importance attributed to farmland tourism is due partly to its potential to advance the local economy and to the benefits it brings for farmers and visitors. Thus, analyzing the role of agritourism in advancing socio-economic prosperity is of pivotal importance. With this background, the paper discusses the economic benefits of agritourism. The results reported in the paper are related to organizations located in Poland and Italy. Agritourism can bring several economic benefits in the countries and regions. What is interesting, the average income from agritourism is about one-third of the overall household income of farmers. Moreover, food service is a crucial factor in the success of agritourism as it brings extra money to farmers. It shows the importance of the relationship between the income obtained from agritourism activities and the benefits local communities gain by engaging in multiple tourism promotion activities.
Polski handel zagraniczny produktami kwiaciarskimi
Authors: Olewnicki Dawid , Jabłońska Lilianna
Published: July 2018

Celem badań był polski eksport i import roślin ozdobnych, mające istotny wpływ na rozwój sektora kwiaciarskiego. Analizowano kierunek i dynamikę zmian w latach 2005-2015, saldo obrotów i strukturę asortymentową w ujęciu wartościowym i ilościowym. Badania wykazały stały wzrost obrotów, nieznacznie szybszy eksportu niż importu, ale przy wyższym absolutnym poziomie importu i ujemnym saldzie obrotów, pogarszającym się w ujęciu wartościowym, jak również wyższych cenach importowych. Polska jest rosnącym importerem netto kwiatów ciętych żywych, roślin doniczkowych i cebul kwiatowych, a staje się także, w wyniku spadku cen, importerem netto roślin szkółkarskich, będących podstawą polskiego eksportu. Polscy szkółkarze powinni przestawiać się na asortyment roślin o wyższej wartości i poprawiać ich jakość w celu podniesienia cen zbytu.
Wzrost pobudzany eksportem czy eksport stymulowany wzrostem sektora rolnego
Authors: Strojny Jacek
Published: July 2018

Celem opracowania jest analiza współzależności między międzynarodową wymianą produktami rolno-żywnościowymi a poziomem produkcji rolnej w wybranych krajach UE. Badanie oparto na metodologii analizy kointegracyjnej i modelach wektorowej autoregresji (VAR). Znaczenie ekspansji eksportowej dla wzrostu produkcji rolnej jest odmienne w poszczególnych krajach UE. W Polsce produkcja rolna jest kształtowana w znacznej mierze poziomem eksportu, ale pozostaje także pod wpływem własnej tendencji rozwojowej. Polski eksport rolno-spożywczy jest kształtowany własną tendencją rozwojową. Dla Francji nie wykryto współzależności między produkcją rolną i eksportem rolno-żywnościowym. Z drugiej strony, eksport jest kształtowany własną tendencją rozwojową i zidentyfikowano zależność między eksportem i produkcją rolną. Podsumowując, w Polsce eksport wspiera produkcję rolną, a we Francji wysoki poziom produkcji sektora rolnego stymuluje eksport.
Płatności bezpośrednie, jako forma wsparcia dochodów gospodarstw prowadzących ekologiczny chów bydła mięsnego
Authors: Szumiec Anna
Published: July 2018

Celem pracy była odpowiedź na pytanie, jaka jest relacja pomiędzy poziomem dopłat otrzymywanych przez gospodarstwa prowadzące ekologiczny chów bydła mięsnego a osiąganym przez nie dochodem z działalności. Badania przeprowadzono w 2014 r., i objęto nimi łącznie 30 gospodarstw, które podzielono na dwie grupy w zależności od ilości wyprodukowanego żywca. Materiał pierwotny do realizacji badań, uzyskano podczas wywiadu bezpośredniego z producentami rolnymi, wykorzystując do tego celu kwestionariusz wywiadu oraz z dokumentacji księgowo-finansowej. Zgodnie z metodyką przyjętą przez IERiGŻ obliczono kategorie dochodowe tj. dochód z działalności bez dopłat i dochód z działalności, a także opłacalność produkcji żywca oraz relację pomiędzy poziomem płatności a wysokością dochodu (%). W I grupie gospodarstw (x=22,56 dt żywca) produkcja żywca przyniosła stratę na poziomie 5 521 zł/gosp., ale dzięki subwencjom udało się osiągnąć dodatni wynik finansowy (tj. 23 576,49 zł/gosp.). Poziom dopłat był o 123,42% wyższy niż osiągane przez te podmioty dochody z produkcji wraz z dopłatami. W II grupie gospodarstw (x=51,00 dt żywca) osiągnięto dodatni wynik finansowy nawet już bez dopłat (tj. 180,18 zł/gosp.).
Unijny eksport i import roślin ozdobnych – zmiany w ujęciu rodzajowym i geograficznym
Authors: Wróblewska Wioletta , Kopiński Łukasz , Paszko Dariusz , Pawlak Joanna
Published: July 2018

Celem artykułu była analiza zmian wartości unijnego handlu zagranicznego roślinami ozdobnymi w 1999 i 2014 roku w ujęciu rodzajowym i geograficznym. Uwzględniono wymianę handlową wewnątrzunijną, a także UE z krajami europejskimi spoza struktur Wspólnoty oraz Afryką, Bliskim Wschodem, Ameryką Płn., Ameryką Łacińską i pozostałymi regionami świata. Analizami objęto eksport i import roślin ozdobnych ogółem oraz siedmiu grup produktów kwiaciarskich. Analizowano saldo, poziom i dynamikę zmian handlu unijnego poszczególnymi grupami roślin ozdobnych z uwzględnieniem struktury geograficznej wymiany handlowej. Posłużono się indeksami o podstawie stałej oraz wykorzystano wskaźniki procentowe. Handel zagraniczny roślinami ozdobnymi UE charakteryzuje zasada bliskości geograficznej. Głównym dostawcą roślin ozdobnych w UE pozostaje Holandia, a głównym odbiorcą roślin ozdobnych z UE, ale o malejącym znaczeniu, były Niemcy. W handlu zagranicznym UE z innymi regionami świata wzrastała rola Afryki, jako dostawcy głównie kwiatów ciętych i sadzonek, malała rola Ameryki Płn. i Łacińskiej jako dostawców głównie zieleni ciętej. Znaczącymi odbiorcami cebul kwiatowych była Ameryka Płn. i Azja.
Zasady wykorzystania środków z Programu Rozwoju Obszarów Wiejskich na lata 2014-2020 do termomodernizacji gospodarstw rolnych
Authors: Huterska Agnieszka , Zdunek-Rosa Ewa , Łapińska Justyna
Published: July 2018

Celem artykułu jest przedstawienie możliwego wsparcia gospodarstw rolnych w inwestycjach umożliwiających ich termomodernizację w ramach Programu Rozwoju Obszarów Wiejskich na lata 2014-2020. Główną metodą badawczą zastosowaną w pracy była analiza dostępnej literatury przedmiotu oraz aktów prawnych, zarówno unijnych, jak i krajowych regulujących poruszane w pracy zagadnienie. Przeprowadzono także porównanie liczby i wartości zakontraktowanych operacji oraz wartości zrealizowanych płatności w ramach PROW 2007-2013 i PROW 2014-2020. Analiza uregulowań prawnych pozwoliła na wskazanie możliwości wsparcia realizacji przedsięwzięć termomodernizacyjnych w gospodarstwach rolnych ze środków unijnych, natomiast analiza danych empirycznych pozwoliła ocenić oba programy pod kątem stopnia realizacji badanego działania na tle wszystkich działań dostępnych w ramach PROW.
Przestrzenne zróżnicowanie produkcji biomasy rolniczej pochodzenia roślinnego w państwach UE w kontekście rozwoju biogospodarki
Authors: Komor Agnieszka
Published: July 2018

Celem artykułu była identyfikacja i ocena przestrzennego zróżnicowania produkcji biomasy rolniczej pochodzenia roślinnego w państwach UE, jako podstawowego surowca wykorzystywanego do wytwarzania bioproduktów oraz bioenergii. W opracowaniu wykorzystano dane statystyczne pozyskane z EUROSTATU. Okres badawczy obejmował 2015 rok. Do interpretacji badań zastosowano statystykę opisową i parametryczną, wykorzystano wskaźniki struktury, gęstości i natężenia, a także wskaźnik korelacji Pearsona. W toku badań stwierdzono, że w 2015 roku 51,5% wytwarzanej w UE biomasy roślinnej w rolnictwie to produkty uboczne - pochodzące z resztek roślin uprawnych, z roślin pastewnych i biomasy wypasanej. Produkcja biomasy roślinnej cechowała się znacznym zróżnicowaniem przestrzennym zarówno w odniesieniu do biomasy pochodzącej z roślin uprawnych (liderami w tym zakresie były kraje: Francja, Niemcy, Hiszpania, Włochy i Polska), jak i do pozostałej biomasy (największy udział miały: Niemcy, Francja, Polska, Wielka Brytania i Włochy). W 2015 roku na terenie siedmiu krajów (tj. Niemiec, Francji, Polski, Wielkiej Brytanii, Hiszpanii, Włoch i Rumunii) wyprodukowano łącznie blisko ¾ roślinnej biomasy wytwarzanej w UE. Analizom poddano również zależności pomiędzy wielkością produkcji biomasy, potencjałem ludnościowym kraju (mierzonym udziałem w liczbie ludności UE) i potencjałem produkcyjnym rolnictwa (mierzonym udziałem w powierzchni użytków rolnych w UE), co pozwoliło na wyznaczenie czterech grup państw.
Warped product pointwise pseudo-slant submanifolds of locally product Riemannian manifolds
Authors: Alqahtani Lamia , Uddina Siraj
Published: July 2018

In [3], it was shown that there are no warped product submanifolds of a
locally product Riemannian manifold such that the spherical submanifold of a
warped product is proper slant. In this paper, we introduce the notion of
warped product submanifolds with a slant function and show that there exists
a class of non-trivial warped product submanifolds of a locally product
Riemannian manifold such that the spherical submanifold is pointwise slant
by giving some examples. We present a characterization theorem and establish
a sharp relationship between the squared norm of the second fundamental form
and the warping function in terms of the slant function for such warped
product submanifolds of a locally product Riemannian manifold. The equality
case is also considered.
Differential polynomials of meromorphic functions sharing a set of values
Authors: Sahoo Pulak , Biswas Gurudas
Published: July 2018

In this paper, we investigate the uniqueness problem of meromorphic functions
when nonlinear differential polynomials generated by them share a set of
values with finite weight and obtain some results which generalize the
results due to H.Y. Xu [J. Computational Analysis and Applications 16
(2014) 942-954].
Large deviations for stochastic integrodifferential equations of the Itô type with multiple randomness
Authors: Haseena A. , Suvinthra M. , Annapoorani N.
Published: July 2018

A Freidlin-Wentzell type large deviation principle is derived for a class of
It? type stochastic integrodifferential equations driven by a finite number
of multiplicative noises of the Gaussian type. The weak convergence approach
is used here to prove the Laplace principle, equivalently large deviation
principle.
The forward order laws for {1,2,3}- and {1,2,4}-inverses of a three matrix products
Authors: Liu Zhongshan , Xiong Zhiping
Published: July 2018

In this article, we study the forward order laws for {1,2,3}- and
{1,2,4}-inverses of a product of three matrices by using the maximal and
minimal ranks of the generalized Schur complement. The necessary and
sufficient conditions for A1{1,2,3}A2{1,2,3}A3{1,2,3}? (A1A2A3){1,2,3} and
A1{1,2,4}A2 {1,2,4} A3{1,2,4}? (A1A2A3){1,2,4} are presented.
Existence results for nonlinear boundary value problems
Authors: Ghanmi Abdeljabbar , Horrigue Samah
Published: July 2018

In the present paper, we are concerned to prove under some hypothesis the
existence of fixed points of the operator L defined on C(I) by Lu(t) = ?w0
G(t,s)h(s) f(u(s))ds, t ? I, ? ? {1,?}, where the functions f ? C([0,?);
[0,?)), h ? C(I; [0,?)), G ? C(I x I) and (I = [0,1]; if ? = 1, I =
[0,?), if ? = 1. By using Guo Krasnoselskii fixed point theorem, we
establish the existence of at least one fixed point of the operator L.
The open-locating-dominating number of some convex polytopes
Authors: Savic Aleksandar , Maksimovic Zoran , Bogdanovic Milena
Published: July 2018

In this paper we will investigate the problem of finding the
open-locating-dominating number for some classes of planar graphs - convex
polytopes. We considered Dn, Tn, Bn, Cn, En and Rn classes of convex
polytopes known from the literature. The exact values of
open-locating-dominating number for Dn and Rn polytopes are presented, along
with the upper bounds for Tn, Bn, Cn, and En polytopes.
Common fixed point theorems for multi-valued weak contractive mappings in metric spaces with graphs
Authors: Sridarat Phikul , Suantai Suthep
Published: July 2018

In this paper, a new type of graph contractive multi-valued mappings in a
metric space with a directed graph is introduced and studied. A common fixed
point theorem of those two multi-valued mappings is established under some
appropriate conditions. Moreover, some examples illustrating our main result
are also given. The obtained result extends and generalizes several fixed
point results of multivalued mappings in the literature. We apply our main
result to obtain common fixed point results for two multi-valued mappings in
?-chainable complete metric spaces and two cyclic contraction multi-valued
mappings.
Some necessary and sufficient conditions for stability of three-layer difference schemes
Authors: Vukoslavcevic Vanja
Published: July 2018

This paper investigates two classes of three-layer difference schemes with
weights in the form ?y?t,n+??2y?tt,n+?1Ayn-1+(E-?1-?2)Ayn+?2Ayn+1 = ?n
and ?y?t,n+??2y?tt,n+A(?1yn-1+(E-?1-?2)yn+?2yn+1) = ?n. It obtains some
sufficient conditions for the stability in a defined norm and, also, in
special cases we achieve conditions for stability which do not depend on the
choice of norm.
Calculation analysis of the effect of uneven distribution of solid fuel on burners on ecological safety of boiler plants of TPPS
Authors: Leikin V. Z.
Published: July 2018

Ensuring environmental safety for energy companies in accordance with the requirements of Federal Law No. 219 of 21.07.2014 is a top priority task today. Experimental studies and industrial experience show that one of the main factors for the formation of virtually all toxic fuel combustion products in boiler plants is the ignition conditions in each burner of the furnace: the fuel-air ratio in the ignition zone, the proportion of primary air, the ratio between the secondary and primary air velocities, etc. However, according to the current regulations, the calculation of emissions of fuel oxides of nitrogen, as well as benz(a)pyrene, is based on averaged values for all burners of the furnace, and the influence of the most important factor — the uniformity of the distribution of fuel and air over the burners — on their formation is not taken into account.

In the work presented, a calculation analysis is performed of the effect of uneven distribution of solid fuel on the burners of boiler plants on emissions of nitrogen oxides, as well as benz(a)pyrene, in combustion products. A calculation procedure has been developed and the dependences of the change in NOx emissions on the nonuniformity of the Δg distribution, the average air excess factor in the αG burners, the number of burners and the dust distribution models have been obtained. It is shown that with the value of the parameter Δg <10%, the uneven distribution of fuel has practically no effect on emissions of nitrogen oxides and benz(a)pyrene, and Δg5 (at which the increase in NOx emissions due to uneven distribution of dust does not exceed 5%) should make: for two burners — 22% ... 27%, four — 12% ... 22%, six — 11% ... 13%. At higher values of Δg and with increasing α, there is a significant increase in emissions of nitrogen oxides and benz(a)pyrene. It is obtained that simultaneously there is a simultaneous increase in NOx and BP. Recommendations are given on the use of dust distribution circuits and designs of dust dividers that meet the requirements to ensure that the uneven distribution of fuel over the burners would not affect emissions of nitrogen oxides.
Secure and safe heat supply of residenal buildings during transional climac condions
Authors: Samarin O. D.
Published: July 2018

An elementary arrangement of a heat supply of residential buildings with direct connection to external heating systems is considered, providing reliability of heat supply and comfort required in indoor premises in case of cold snaps after the official closure of the heating season, or before the beginning of the same, by supplying water from the return main of the heating system after the hot water heat exchangers. The basic equations are analyzed relating the heat transfer to the heating system with water temperature in the manifold, the inside air temperature and the characteristics of the heaters, with a review of possible methods of regulating the heat supply near the beginning and the end of the heating period provided taking into account requirements of normative documents of the Russian Federation. Calculations are performed to determine the amount of the main components of the heat balance of a residential building on the example of one of the standard projects used currently in the climatic conditions of Moscow taking into account the constructive structural characteristics of the building and its occupancy level. Analysis of the obtained results and conclusions regarding the appropriateness of the application of this arrangement are provided. It is established that the actual heat output of the heating system when using a chilled water network down-stream the hot water supply heat exchangers as a heat source enables to maintain the safe indoor temperature in the building, with the average daily temperature of outdoor air above +2° C in conditions of moderate amount of heat received with solar radiation. It is shown that the use of this arrangement is virtually not accompanied by additional costs, provides hydraulic resistance of the heating system and gives a system-wide effect in the form of higher electricity generation at thermal consumption when using cogeneration.
Fulity of use of expander-generator sets at thermal power plants
Authors: Kulichikhin V. V.
Published: July 2018

The so-called expander-generator sets (EGS) have found some application in Western Europe. Their operation is based on a drop in the pressure of natural gas (NG), which comes to a power-generating or industrial facility, and which used to be lost in choking devices of the gas distribution station (GDS) of these facilities. The capacity of such sets, e.g., in Germany, is limited to just tens to hundreds of kilowatts. The benefit for their owners lies in obtaining, according to the German law, markups to the cost of energy released to electricity consumers. However, the economic environment in place in Russia is somewhat different.

According to the author, the limited number of  EGS in Russia’s power industry, as well as cases of their decommissioning, are due to the lack of evidence of their thermodynamic or technical-economic efficiency, or even worsening economic conditions at facilities, where those were implemented. Besides, the facilities in question have to be provided with considerable specific conditions. These include a relatively high value of initial NG pressure at the input of EGS, its considerable flow rate and the possibility of NG heating at the input of EGS. This necessity to heat NG upstream the EGS is determined, on the one hand, by the intention to enhance the EGS capacity, and on the other hand, by having to comply with requirements imposed by the EGS manufacturer regarding the temperature values upstream and downstream the EGS. Without a required source of heat of relevant parameters at the facility, application of EGS turns out to be impossible, altogether. An interest in EGS in Russia arose due to construction and commissioning (first, at CHPP-21, and later at CHPP-23 of Mosenergo) of two power-generating centers, each equipped with two 5 MW EGS. Since then, a large number of articles have been published, and numerous theses have been defended based on the studies undertaken, mostly of analytical nature. Yet, those publications have not considered, for a real expander, matters of effects produced by the relation between the absolute electrical efficiency (ηe) of CPP and/or CHPP and the efficiency ratio of expander (ηer ), the NG expansion ratio (δ). Conditions, at which heating NG upstream the EGS is expedient, have not been established, either, whereas these are the factors crucial for economic feasibility of a TPP to be equipped with EGS.
Análise da situação de saúde apresentada por mulheres obesas de acordo com um core set resumido da CIF
Authors: Costa André Carvalho , Leal José Carlos , Silva Raimisson Vieira , Pernambuco Andrei Pereira , Vassimon Helena Siqueira , Brunherotti Marisa Afonso Andrade
Published: July 2018

Introdução: A obesidade é uma doença crônica caracterizada pelo excesso de tecido adiposo. Existem cerca de 600 milhões de obesos no mundo e, à medida que as pessoas se tornam obesas ou permanecem nessa condição por períodos prolongados, maior é o impacto nas estruturas e funções corporais. A obesidade também pode influenciar negativamente a realização de atividades de vida diária e participação social. Atualmente, a Classificação Internacional de Funcionalidade, Incapacidade e Saúde (CIF) é o instrumento mais apropriado para classificar a funcionalidade e incapacidade de indivíduos e populações. Objetivos: Analisar a funcionalidade e incapacidade de mulheres com obesidade tipo I ou II por meio do core set resumido da CIF. Metodologia: Participaram 72 mulheres, com idades entre 20 e 40 anos, cadastradas em Unidades Básicas de Saúde de um município do Centro Oeste de Minas Gerais. O índice de massa corporal foi determinado e em seguida utilizou-se o core set resumido da CIF, desenvolvido para a obesidade. Resultados: A categoria “Função do Corpo” mais afetada foi b130 – Funções da energia e dos impulsos (65,3% da amostra). Com relação aos componentes “Atividades e Participação”, notou-se que a categoria d455 – deslocar-se, foi a mais comprometida (79% da amostra). Por fim, a categoria de “Fatores Ambientais” que mais atua como barreira foi e310 – família próxima (55,5% da amostra). Conclusões: Achados do estudo podem direcionar a tomada de decisão clínica e permitir que as ações sejam direcionadas para as reais necessidades dos pacientes, melhorando assim a resolutividade dos serviços e a satisfação dos pacientes.
Avaliação da presença de estafilococos coagulase positiva em “queijo minas artesanal” comercializados na microrregião de Bom Despacho-MG
Authors: Mendes Leticia Aparecida Barbosa
Published: July 2018

Introdução: Em Minas Gerais o consumo de queijo é tradicional, por isso, o Instituto Mineiro de Agropecuária (IMA) regulamentou o processo de produção do “Queijo Minas Artesanal” no estado, através da lei nº 14.185 de 31 de janeiro de 2002, porém ainda existem muitos produtores que não seguem essas especificações, principalmente no interior do estado, o que gera produtos sem segurança microbiológica, tendo como principal patógeno os estafilococos, por isso, a quantificação de estafilococos coagulase positiva, regulamentada pela RDC nº 12 de 2 de janeiro de 2001, é o principal parâmetro da qualidade de queijos. Objetivo: Pesquisar estafilococos em “Queijo Minas Artesanal” frescos, comercializados na microrregião de Bom Despacho-MG. Metodologia: Selecionamos cinco cidades da microrregião de Bom Despacho, para a realização de uma análise microbiológica em “Queijo Minas Artesanal” sem selo de certificação, comercializados nessas cidades. Resultados: Seguindo a RDC nº 12 de 2 de janeiro de 2001, apenas um queijo apresentou estafilococos coagulase positiva acima das normas sanitárias, mas quatro das cinco amostras apresentaram alta contagem de estafilococos coagulase negativa, o que também é um risco a saúde do consumidor. Conclusão: A partir dos resultados, percebe-se a importância da vigilância microbiológica neste tipo de alimento, e vê-se o quão necessário é a implantação de boas práticas higiênico-sanitárias na produção, no armazenamento e na comercialização desse produto.
Dewey in Argentina: Tradition, intention, and situation in the production of a selective reading
Authors: Caruso Marcelo , Dussel Inés
Published: July 2018

From the 1910s on, Argentinean educators looked repeatedly at Dewey’s work in search for models of educational reform. However, his undisputed reputation as a major thinker contrasted with a very selective view of his work and a weak reception in institutional terms. In fact, substantial parts of his scholarship were marginalized, in a selective reading that produced a de-politicized version of Dewey as an educational reformer. The multiple relationships between “democracy” and “education” or “schooling” opened up by Dewey’s thought were reduced in Argentina to a peculiar “didactics,” in a movement that reflected the intellectual and political trajectories of the supporters of the New Education Movement. In this chapter, working through translations, articles and comments on Dewey’s work, we will will focus on understanding the range of alternative readings that were available at a particular time, and the contexts of debate in which they became possible. The liberal and Catholic traditions of reading foreign references and models will be put together with the struggles that organized political oppositions in the period considered, and with the particularly heated climate (first democratically elected government, military dictatorships, Perón’s election) that marked these years and that tainted Dewey’s reception in Argentina.
John Dewey and the Development of Education in Russia before 1930 - Report on a forgotten reception
Authors: Mchitarjan Irina
Published: July 2018

This article explores the kinds of response John Dewey (1859–1952) received in Russia between 1900 and 1930, and the impact he had on the educational debate there. The study’s main findings are: Both before and after the Socialist October Revolution of 1917, Dewey had a significant impact on the development of the Russian school system. The ultimate rejection of Dewey’s pedagogy towards the end of the 20s was not due to educational but to political and ideological reasons.
Off the beaten track: a reflection on intention and unpredictability in arts education research
Authors: Gallagher Kathleen
Published: July 2018

The coherence of a ‘research program’ is often betrayed by the unanticipated turns and detours in arts research. The following article reflects upon the place of the unexpected in arts research, the alternative ways in which knowledge or ‘findings’ are often constructed, and the complexity of calibrating or measuring arts research for broader publics. UNESCO’s road map is seen here as a site for further deliberation, a point in time and space that should engage arts communities in rousing dialogue—locally and globally—about the convergences and divergences of our practices and research paradigms.
Educación docente e integración cultural en programas de estudio de universidades chilenas. Un estudio de caso.
Authors: Merino María Eugenia
Published: July 2018

En este estudio se examina el grado de incorporación de conocimiento sobre las culturas indígenas en los programas de formación docente Educación de Párvulos y Educación Básica de tres universidades chilenas, ubicadas en las regiones de Tarapacá, Valparaíso y Araucanía. Se analiza por una parte, los currícula, programas y perfiles profesionales y, por otra, las voces de los estudiantes de dichos programas. Los resultados revelan que la casi totalidad de los currícula de formación docente estudiados no incorporan saberes de las culturas ancestrales del país (aymara, quechua, pascuense, mapuche), como tampoco incluyen la interculturalidad como una opción de formación docente. Ello demuestra que la educación docente en los programas estudiados no constituye un puente eficaz en el proceso de formación que permita a los futuros profesores constituirse en actores para el cambio educativo, tampoco ofrecen una formación docente adecuada para actuar en contextos culturales con alta población indígena. Finalmente los programas analizados no incluyen las voces de aquellos que han sido históricamente marginados, como son los grupos indígenas del país.
Are We Educating or Training?
Authors: Jofré Ana
Published: July 2018

Special Feature - no abstract
Cambios paradigmáticos en la formación de profesores: peligros, trampas y la promesa no cumplida del profesional reflexivo
Authors: Russell Tom
Published: July 2018

Los programas de formación inicial docente tienden a estar saturados con referencias a la reflexión, a la práctica reflexiva y a la importancia de volverse un profesional crítico y reflexivo. A más de 25 años desde que los educadores comenzaron a considerar el concepto de Schön, hay poca evidencia de que el potencial de su idea de un profesional reflexivo se haya desarrollado en nuestras escuelas y programas de formación pedagógica. Este capitulo hace una revisión de literatura especializada sobre la práctica reflexiva en la formación inicial docente para construir una explicación acerca del hecho que los tan anhelados cambios paradigmáticos no han ocurrido. La complejidad de cambios paradigmáticos, la estabilidad de las prácticas docentes, y la significatividad del aprendizaje por observación que todos los profesores y formadores de profesores traen consigo a su trabajo son considerados en la construcción de una explicación de los muchos peligros y trampas asociadas al incumplimiento de la promesa del concepto de profesional reflexivo en la formación de profesores.
The Author Replies (English)
Authors: Jofré Ana
Published: July 2018

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