bluuebunny/crossref_metadata_2025 huggingface dataset:
»nicht in Beziehung zu setzen« …
Authors: Schuchter Veronika
Published: May 2024

Der folgende Beitrag untersucht die Bedeutung des Geschlechts für Prozesse des Vergleichens in verschiedenen Ausprägungen im literarischen Feld. Der Fokus liegt dabei auf der feuilletonistischen Literaturkritik. Das Geschlecht wirkt als (meist unbewusste) Trennlinie bei der vergleichenden Einordnung von Autorinnen und Autoren, es beeinflusst die Bildung und Prolongation von Traditionslinien. Vergleiche von Autor*innen strukturieren homosoziale Felder, wobei nur die weiblichen Felder als solche markiert werden. So kommt es zu weiblichen, biografisch aufgeladenen Traditionslinien, die nur von Autorinnen mit einem als einzigartig wahrgenommenen Stil, wie etwa Ilse Aichinger, durchbrochen werden, ohne deshalb in einen geschlechtsneutralen Vergleichskanon aufgenommen zu werden.
Verständige Vergleichung
Authors: Baßler Moritz
Published: May 2024

Der Vergleich ist die paradigmatische Trope, die Äquivalenzen herstellt. Was aber entspricht der Vergleichsoperation auf der syntagmatisch-metonymischen Achse? Das Nachdenken über Prinzipien der Kontiguität und Referenz verspricht neue Aufschlüsse auch über das realistische Erzählen unserer Gegenwart.
Efficacy of antiparkinsonian therapy in tremor correction according to tremorography
Authors: Bogacheva V. A. , Zakharov D. V. , Mikhailov V. A.
Published: May 2024

Objective: to evaluate the efficacy of antiparkinsonian drugs of different groups considering the frequency-amplitude characteristics in the correction of tremulous hyperkinesis in Parkinson's disease (PD) using tremorography. Material and methods. 172 patients with a confirmed diagnosis of PD were observed. Taking into account age and contraindications, patients were divided into four groups receiving one of four drugs in monotherapy: dopamine receptor agonists (ADR; pramipexole), levodopa (Tidomet forte), anticholinergics (biperiden), amantadines (amantadine sulfate). Before starting treatment and after completion of the selected therapy, patients underwent tremorography to analyse the frequency, amplitude and duration of tremor over time in four standard tests. Results. All antiparkinsonian drugs reduced rest tremor, and the efficacy of pramipexole in treating tremor was comparable to that of levodopa in the early stages of the disease. As the severity of the disease increased, the efficacy of ADRs decreased, whereas levodopa became more important. Amantadine sulfate showed the lowest efficacy in rest tremor. The efficacy of anticholinergics against tremor is high but inconsistent. Conclusion. We demonstrated feasibility of using tremorography in the selection of an individualised treatment programme for patients with shaking hyperkinesis in PD , and the high efficacy of levodopa in shaking hyperkinesis was confirmed.
The use of thromboaspiration and combined treatment in patients with ischemic stroke in real-life clinical practice
Authors: Volchenkova T. V. , Kotov S. V. , Isakova E. V. , Sutormin M. V. , Patrin E. V. , Gegenava B. B. , Martynovich M. N. , Rudakova I. G. , Smetana L. V. , Borisova V. A. , Belkina S. V.
Published: May 2024

The effectiveness of staged reperfusion therapy in real clinical practice requires clarification. Objective: to evaluate the efficacy and safety of mechanical thromboextraction and staged reperfusion therapy with alteplase in real clinical practice. Material and methods. The study included 106 patients who were retrospectively divided into two groups: Group I underwent staged reperfusion therapy (intravenous thrombolysis with alteplase followed by aspiration thromboextraction), Group II underwent thromboaspiration only. The clinical and functional results, incidence of hemorrhagic transformation and mortality rate were compared. Results. The groups did not differ in terms of demographic data, cardiovascular risk factors or stroke severity. Group II patients were characterized by a longer delay in reperfusion therapy (225 minutes versus 180 minutes) and a lower score on the Alberta Stroke Programme Early CT score (ASPECTS; 8.8 points versus 9.3 points). There were no differences in National Institutes of Health Stroke Scale (NIHSS) scores at day 28, dynamics of NIHSS scores, Rankin scores at day 28, rates of hemorrhagic transformation or mortality. In both groups, the deceased patients were older; in Group I they suffered more frequently from atrial fibrillation, in Group II – from diabetes mellitus type 2. In addition, mortality in Group II was associated with a higher severity of early signs of cerebral infarction.Conclusion. The results of the analysis of real-life clinical practice show the comparability of the efficacy and safety of staged reperfusion therapy and isolated thromboaspiration in a “natural” selection of patients.
Diagnosis of Alzheimer's disease by using biological markers in posterior cortical atrophy
Authors: Grishina D. A. , Khayalieva N. A. , Grinyuk V. V. , Tyurina A. Yu.
Published: May 2024

The use of biological markers for Alzheimer's disease (AD) allows diagnosis at the stage of moderate cognitive impairment and atypical course of the disease. We present two clinical cases of patients with posterior cortical atrophy (PCA), characterized by progressive impairment of visual and spatial functions due to atrophy of the parietal and occipital lobes of the brain. A differential diagnosis was made between AD, corticobasal degeneration and other diseases in which PCA syndrome occurs. In the cases observed, the patients showed a significant decrease in the level of beta-amyloid in the cerebrospinal fluid, which allowed the diagnosis of AD to be made. Clinical manifestations, diagnosis and treatment of PCA syndrome are discussed. At present, the diagnosis of AD at the stage of moderate cognitive impairment and mild dementia is of practical importance, as anti-amyloid therapy can prevent the progression of AD.
Modelling long-term outcomes and mortality risk in patients with post-stroke spasticity during abobotulinum toxin injections as part of rehabilitation
Authors: Khatkova S. E. , Gilweg A. S.
Published: May 2024

To date, there are no Russian or international studies investigating the long-term efficacy of botulinum therapy (abobotulinum toxin injections – AboBTX) during rehabilitation in patients with post-stroke spasticity in terms of its impact on the risk of death from all causes and the development of cardiovascular complications. A 10-year study conducted in the United Kingdom analyzed the effects of AboBTX injections in patients with post-stroke spasticity on long-term clinical (all-cause mortality, cardiovascular events, length and quality of life) and economic (direct medical costs) outcomes. For the first time ever, a model was developed to evaluate the clinical (quality-adjusted life expectancy) and economic benefits of AboBTX injections in the structure of rehabilitation compared to rehabilitation without botulinum therapy in patients with post-stroke spasticity. It was shown that the inclusion of regular injections of AboBTX in the rehabilitation process resulted in an 8.8% reduction in the risk of death from all causes, a 13% increase in life expectancy (and by 59% in quality-adjusted terms compared to rehabilitation without botulinum therapy) and proved to be cost-effective. The use of AboBTX injections in patients with post-stroke spasticity as part of rehabilitation is cost-effective in the long term and improves long-term outcomes, including post-stroke survival.
Alzheimer's disease: diagnosis and treatment, errors in patient management
Authors: Parfenov V. A. , Grishina D. A. , Tyurina A. Yu.
Published: May 2024

Alzheimer's disease (AD) is the most common degenerative disease of the brain leading to dementia. AD is the most common cause of disability among age-related diseases. The diagnosis of AD is based on clinical findings and is confirmed by the presence of positive biological markers of the disease, which reflect the pathological formation of beta-amyloid and tau protein in the brain. Magnetic resonance imaging of the brain shows brain atrophy in AD and helps to rule out other diseases. Psychosocial and behavioral approaches form the basis for the treatment of patients with AD; cognitive training in combination with regular physical exercise is recommended. Acetylcholinesterase inhibitors and the glutamate receptor blocker memantine are used as drugs that improve the cognitive functions of patients with AD. Dispersible forms of memantine are used to treat dysphagia in patients with AD. The efficacy and safety of pathogenetic therapy aimed at eliminating cerebral beta-amyloid by passive immunization is under discussion. Unfortunately, AD is rarely diagnosed in our country; doctors are not sufficiently informed about the diagnosis and modern treatment methods of AD. Many AD patients are observed with the misdiagnosis of chronic cerebrovascular disease and do not receive effective therapy. A clinical observation of a patient with early-onset AD is presented, reflecting typical errors in patient management. Issues for optimizing the management of AD patients are discussed.
Return of the Atlantic Route from West Africa to Europe
Authors: Cross Hannah
Published: May 2024

As dangerous trans-Atlantic crossings between Africa and Europe continue to rise, Hannah Cross examines the roots of the ongoing crisis. The discussion around migration, she notes, "overlooks the imperial role of Europe and the United States over borders, migration regimes, regional (de-)integration, and national development projects within Africa." The solution, therefore, can only be found through genuine liberation and autonomy across the continent, rather than internationally imposed mechanisms benefitting the powerful in the Global North.
Experiências entrelaçadas
Authors: Campos Maria Machado Malta
Published: May 2024

Ao me preparar para escrever este depoimento, relendo algumas entrevistas de anos anteriores, encontrei minha resposta à pergunta de uma jornalista: “A senhora é licenciada em Pedagogia e fez doutorado em Sociologia. O que a levou a estudar, pesquisar, sobre a Educação Infantil?”
Depois de tentar explicar com maiores detalhes o que ela indagava, tentei resumir meu percurso profissional, pessoal e intelectual da seguinte forma: “Creio que essa interface entre a experiência de pesquisa sobre crianças de pré-escola e a interação com movimentos de mulheres na área de creche, mais a fundamentação sobre movimentos sociais na sociologia, acabaram por trazer-me para o campo que hoje chamamos de educação infantil.”
Penso que nessa explicação, eu estava de algum modo descrevendo como tem sido vivida minha caminhada neste território que a Anped chama de “pedagógico”, ao entrelaçar, nem sempre facilmente, três tipos de experiências: o que ia aprendendo nas atividades de pesquisa e na pós-graduação, como aluna e depois professora; o que vivia em grupos, organizações e mobilizações coletivas; e nas oportunidades de formação ao longo dessa trajetória.
Peranan Notaris Dan PPAT Dalam Perjanjian Melalui Media Elektronik (Menghadapi Revolusi Industri 4.0)
Authors: Fahrurrozie Muhamad Anas , Priyono Ery Agus
Published: May 2024

AbstractThe rapid use of information technology in activities based on electronic transactions, for example, online loans through Finance Technology e-commerce, brand registration, registration of fiduciary certificates, etc. In fact, it has’nt been followed by legal developments that can keep up with the development of advances in communication and information technology. Therefore, it is necessary to have legal certainty so there are no problems or disputes that occur in cyberspace. The problem that arises is the difference in authority between a Notary and PPAT; What are the legal consequences of a Notary deed and PPAT in an agreement through electronic media? How to prove the authentic deed through electronic media if there is dispute in court? The method used is a normative juridical method. The purpose of the Notary and PPAT is to stabilize the legal relationship between the parties in a written form and certain format, so that an authentic deed is a strong document maker in a legal process so that there is no dispute between the Notary and the PPAT in the implementation of their duties and authorities, namely in making a good deed. the parties or the deed that must face or meet physically in one place.Keywords: legal certainty; agreement; notary.AbstrakPesatnya pemanfaatan teknologi informasi dalam kegiatan yang berbasis transaksi elektronik seperti halnya pinjaman online untuk e-commerce teknologi keuangan, pendaftaran merek dagang, pendaftaran sertifikat perwalian, dll. Bahkan hukum terus mengikuti kemajuan teknologi komunikasi dan informasi yang berkembang saat ini. Oleh karena ini dibutuhkan kehadiran kepastian hukum agar dapat tidak terjadi permasalahan atau sengketa yang terjadi di dunia maya. Permasalahan yang muncul Apakah perbedaan kewenangan antara Notaris dan PPAT; Bagaimana akibat hukum dari akta Notaris dan PPAT dalam suatu perjanjian melalui media elektronik? Bagaimanakah pembuktian akta otentik melalui media elektronik apabila ada suatu sengketa di pengadilan? Metode yang digunakan menggunakan metode yuridis normative. Tujuan notaris dan PPAT adalah memberi pernyataan hubungan hukum antara para pihak dalam bentuk tertulis dan dalam format tertentu, sehingga autentikator merupakan dokumen yang kuat dalam suatu proses hukum. pelaksanaan tugas dan wewenangnya, yaitu dalam pelaksanaan suatu perbuatan baik para pihak atau perbuatan saling berhadapan atau bertemu di suatu tempat.Kata kunci : kepastian hukum; perjanjian; notaris
ASPEK HAK KEKAYAAN INTELEKTUAL DALAM PENGEMBANGAN POTENSI 12 DESTINASI WISATA PESISIR DI JAKARTA UTARA
Authors: Mahatmi Dini
Published: May 2024

Upaya pengembangan dan penciptaan nilai tambah secara berkelanjutan bagi berbagai potensi kepariwisataan  diperlukan perlindungan hukum atas berbagai karya, baik untuk yang telah ada maupun yang akan dihasilkan nantinya. Berkaitan dengan ini Pemerintah Kota Jakarta Utara bermaksud memberikan perlindungan hukum atas kekayaan intelektual sehingga dapat menjaga orisinalitas, serta menghindari  pemalsuan atau persaingan usaha yang tidak sehat. Tujuan dari penyusunan tesis ini adalah melakukan audit atas potensi perlindungan hukum bagi berbagai atribut produk yang ada dapat diidentifikasi, berbagai atribut produk yang dipandang perlu untuk mendapatkan perlindungan HKI. Pendekatan penelitian yang digunakan adalah yuridis empiris karena penelitian hukum ini menggunakan data dari bahan-bahan pustaka (data sekunder), dan data yang diperoleh langsung dari masyarakat (data primer). Hasil penelitian ini memberikan kesimpulan bahwa dengan keragaman yang ada, jenis atribut produk yang memerlukan perlindungan tersebut dapat dibagi dalam 2 kelompok, yaitu : (1) obyek perlindungan yang bersifat umum, dapat diimplementasikan pada 12 Destinasi Wisata, dan (2) obyek perlidungan yang bersifat spesifik berkaitan dengan identitas masing-masing destinasi. Hal yang memerlukan perhatian lebih lanjut bila proses perlindungan tersebut dilakukan adalah, bahwa kepemilikan atau penguasaan pelaksanaan pengelolaan atas masing-masing destinasi dilakukan oleh berbagai pihak, baik yang dikuasai atau dikelola oleh badan hukum maupun oleh masyarakat.
EFEKTIVITAS PERJANJIAN PENANGGUNGAN SEBAGAI PENGIKATAN JAMINAN KREDIT DI BANK PERKREDITAN RAKYAT KRANJI KRIDA SEJAHTERA KOTA BEKASI
Authors: Sutraduga Antoni
Published: May 2024

Dalam praktik sampai saat ini penggunaan Jaminan Perorangan masih ada dan  tetap dipersyaratkan dalam pemberian kredit dikalangan perbankan nasional, seperti pada Bank Perkreditan Rakyat (BPR) Kranji Krida Sejahtera Kota Bekasi yang masih mempersyaratkan Jaminan Perorangan. Adapun tujuan yang dilakukan untuk penelitian ini adalah Untuk mengetahui pelaksanaan perjanjian kredit dan efektifitas Perjanjian Perorangan di BPR Kranji Krida Sejahtera Kota Bekasi dapat menjamin penyelesaian kredit bermasalah apabila Debitor Wanprestasi.Penelitian ini dilakukan dengan melakukan pendekatan secara yuridis empiris, berupa penelitian tentang pengaruh berlakunya hukum positip dari aspek hukumnya dan tentang pengaruh berlakunya terhadap masyarakat dalam pemecahan masalah. Penelitian menunjukkan bahwa di BPR Kranji Krida Sejahtera, pemberian kredit dengan adanya jaminan perorangan masih dipersyaratkan oleh pemutus kredit namun hanya diberlakukan khusus untuk penambahan modal usaha baik perorangan maupun perseroan terbatas (PT), maupun usaha bersama-sama (CV),  dan selain itu kredit untuk diluar dunia usaha, dengan melihat kondisi debitor dan usahanya tanpa melihat nilai jaminan kebendaan dari debitor. Jaminan Perjanjian Penanggungan akan efektif pada saat debitor pada tahapan “kurang lancar” dalam memenuhi kewajibannya kepada kreditor yang dalam praktek perbankan dikategorikan dalam klasifikasi ”collectibility 1” (Coll 1) yaitu apabila debitor tidak membayar kewajibannya kepada kreditor selama 1 sampai 4 bulan.
PELAKSANAAN PENDAFTARAN TANAH PERTAMA KALI SECARA SPORADIK DI KANTOR PERTANAHAN KABUPATEN BREBES
Authors: Hasan Samana Ahmad Nur
Published: May 2024

Pengaturan pendaftaran tanah di Indonesia diatur dalam Undang-undang Nomor 5 tahun 1960, yang lebih dikenal dengan istilah UUPA. Mengingat Pasal 19 ayat (1) UUPA maka pengaturan pendaftaran tanah di Indonesia yang lebih rinci diatur dalam  Peraturan Pemerintah Nomor 24 Tahun 1997 tentang Pendaftaran Tanah. Permasalahan dalam penelitian ini adalah bagaimana pelaksanaan pendaftaran tanah pertama kali secara sporadik dan faktor-faktor penghambat dan pendukung dalam pelaksanaan pendaftaran pertama kali  di Kabupaten Brebes. Penelitian menunjukkan bahwa praktek pelaksanaan pendaftaran tanah pertama kali secara sporadik di Kabupaten Brebes menunjukkan prosentase yang signifikan dengan tingkat kebutuhan masyarakat. Hal ini terlihat dari animo masyarakat yang lebih cenderung menggunakan jasa PPAT sebanyak 60% dan 40% secara sistematik. Faktor pendukung dan penghambat dalam pendaftaran tanah secara sporadik adalah keterbatasaan pemahaman masyarakat dan data yang di punyai belum lengkap, sementara itu faktor pendukungnya supaya tanah yang di punyai mempunyai kepastian dan pelindungan hukum yang berbentuk sertipikat. Kepada masyarakat supaya tidak merasa enggan dalam melaksanakan pendaftaran tanah, mengingat akan pentingnya bukti yang dapat memberikan kekuatan dan kepastian hukum terhadap bidang tanah yang dimilikinya, dan kepada kantor pertanahan agar memberikan sosialisasi hukum di bidang pertanahan kepada masyarakat, sehingga diperoleh pemahaman mengenai prosedur dan proses pendaftaran tanah pertama kali secara sporadik.
The Landmine Rotation
Authors: Allen Charles R. , Mantei Devin R. , Wallace Zack T.
Published: May 2024

The landmine rotation is a multipurpose, total body, strength and power exercise that bridges the gap between traditional resistance exercise and rotational sport specificity. This article describes proper landmine rotation technique, outlines several variations, and offers programming recommendations.
Heart Failure Registries in Asia – What Have We Learned?
Authors: Balagopalan Jayagopal Pathiyil , Abdullakutty Jabir
Published: May 2024

Heart Failure (HF) is one of the leading problems in cardiology practice today. Acute decompensated heart failure (ADHF) is a significant cause of mortality and morbidity worldwide, and this is more relevant in the Asian subcontinent with a high population burden. Various regional registries in Asia have given us valuable insight into the aetiology and outcomes in this context. Though there are regional differences, it is clear from the review carried out in this paper that HF affects a much younger population. The comorbidities like diabetes and hypertension are high. Chronic kidney disease and atrial fibrillation are higher compared to the Western cohort. Heart failure with preserved ejection fraction is less often seen. The in-hospital mortality ranges from 2.8% to 8.4%. The one-year mortality is higher, and re-hospitalization is very high. Though in many Asian countries, guideline-directed medical therapy is initiated in hospitals, adherence is low. This is the challenge, and the way forward is only a practical team-based heart failure treatment approach. In the modern-day world of digital technology, the onus is on us to develop an integrated system of care in HF. This is by using available resources and opening up HF clinics. This review compares the strengths and limitations of various heart failure registries conducted in Asia and also gives a direction to plan effective strategies for improving heart failure care.
Singapore’s Temasek Model and State Asset Management in China
Authors: Leutert Wendy
Published: May 2024

Since the late 1970s, Singapore has been an important policy reference for China. Some Chinese policymakers viewed Temasek, its government holding company, as a model for state asset management. They studied Singapore’s approach, but ultimately chose a different institutional design when establishing the State-Owned Assets Supervision and Administration Commission (SASAC) in 2003. China’s engagement with Temasek subsequently concentrated on corporate governance, specifically boards of directors in state-owned enterprises (SOEs). Yet despite the Temasek model’s appeal, its influence in China was limited by the far greater size and indebtedness of the state sector; the weaker role of firm performance in asset and capital allocation; SOEs’ numerous social and welfare functions; lack of willingness to augment firm autonomy; and divergent interpretations of the Temasek model and its reference value. “Policy collage” by Chinese policymakers explains the existence of formal similarities between China and advanced capitalist economies without fundamental convergence in function.
The Belle Époque Queer Fairy Tale
Authors: Valentine Colton
Published: May 2024

This essay works to define, historicize, and probe the queer fairy tale subgenre. Recuperating Vladimir Propp’s syntagmatic formalism from a queer angle, I argue that fairy tales’ protean, fantastical qualities afford rapid and imaginative refashioning across languages by LGBTQ+ writers. In Belle Époque tales by Vernon Lee, Oscar Wilde, Laurence Housman, Jean Lorrain, and Renée Vivien, I locate a poignant vision of queer futurity.
Mining Charity
Authors: Weicksel Sarah Jones
Published: May 2024

Scalding water, plummeting cage elevators, cave-ins, fiery explosions, toxic air. These were among the many hazards of silver ore mining on Nevada’s Comstock Lode in the late 1800s. This article explores the nature of silver mining society in the 1860s and 1870s, focusing on the dangerous conditions in which miners worked in the mineshafts that ran beneath the communities of Virginia City and Gold Hill, Nevada. The material culture and conditions of mining, the article argues, were central to determining the community’s needs and the charitable efforts mounted to address them. Philanthropic work and fundraising for a diverse set of causes—from attending to individuals’ needs to building a hospital to running an orphanage—shaped residents’ social and cultural lives, as well as the built environment in which they lived.
Prerequisites for the Development of Shipping Ukraine
Authors:   Odesa National Maritime University, Kotlubai Oleksii , Poznanska Inna ,   Odesa National Economic University
Published: May 2024

The article provides coverage of possible approaches to the formation of economically attractive conditions for the operation of ships after the victory, which today is the main goal of the economic science of the maritime industry. In this regard, the main task of the publication is the implementation of strategic goals in shipping, the need to ensure the competitive advantages of Ukraine's foreign trade and the efficiency of work on the global freight market. In addition to the size of the total deadweight, the article provides approaches to establishing an economically feasible number of fleet units that will meet the conditions for achieving the lowest risk of the probability of loss-free operation of each shipping company. This is due to the fact that there is an optimal number of ships in which the losses incurred by one ship are compensated by the profit received by another fleet. The conclusions provide recommendations for the development of shipping in Ukraine.
Graphene-cellulose hydrogels: An apt combination
Authors: Yuan Zhongfei
Published: May 2024

Graphene-cellulose hydrogels have been extensively studied in the field of functional hydrogels. This editorial presents an overview of graphene-based and cellulose-derived materials, highlighting the unique characteristics of these two materials and the synergistic advantages achieved by combining them to construct graphene-cellulose composite hydrogels. The aim is to provide novel insights for developing functional cellulose-based hydrogels enabled by carbon nanomaterials.
Assessing Progress in Reducing the Number of Disaster-affected People: Insights from Zimbabwe
Authors: Mavhura Emmanuel
Published: May 2024

In 2015, 187 countries appended their signatures to the Sendai Framework for Disaster Risk Reduction. This framework has seven global targets which need to be monitored both at national and global levels. In order to promote the monitoring and reporting on progress in attaining the global targets, the United Nations Office for Disaster Risk Reduction provided some technical guidance notes and methodologies. Using the case study of Zimbabwe, this study used the technical guidance notes and methodologies to assess the country’s progress in reducing the number of people affected by disasters. Quantitative data for this assessment came from public sources published by the Government of Zimbabwe spanning the period 1990 to 2019. This data was analysed using 3-year and 5-year moving averages. In addition, the study used qualitative interviews to explain the trends in the number of people affected by disasters. Results showed slight decreases in the number of people affected by both aggregated and disaggregated disasters. Drought disasters emerged as the only one that affected millions of people yearly. However, storms and epidemics were sporadic and characterised by big spikes. The study concluded that Zimbabwe is slowly attaining Target B. The study further offered three policy implications that are meant to significantly reduce the number of people affected by disasters. This includes the need to strengthen drought preparedness/mitigation, and disease surveillance and control systems.
Beyond the aesthetic purposes of the botilinum toxin A; The dry eye syndrome with essential blepharospasm
Authors: Karaarslan Cuneyt
Published: May 2024

Botulinum A toxin injection is a method used in clinical conditions such as blepharospasm, hemifacial spasm, strabismus, migraine, hyperhidrosis, torticollis and migraine, in addition to its use for cosmetic purposes. It works by reducing the release of acetylcholine at the neuromuscular junction, and as a result, a type of paralysis occurs in the applied area for a while. Botox applied around the tear collection ducts can provide dual benefits by reducing tear loss and relieving blepharospasm. In this study, botulinum toxin A injection was applied to 33 patients with essential blepharospasm and also dry eye syndrome. Schirmer test measurement, tear breakup time (BUT) and rose bengal disappearance test were measured before the injection and at the 1st week, 1st month and 3rd month after the injection. At the same time, sampling was performed for impression cytology before the injection and at the 1st and 3rd months after the injection. Symptoms and signs of blepharospasm decreased in all patients treated with botulinum toxin A. However, the patients' Schirmer test measurements were measured immediately one week after the injection and decreased in other measurements. Tear breakout time (BUT) increased in the 1st week after the injection but decreased in the 4th week measurements. Rose bengal disappearance score increased in the 1st week after injection and returned to its previous state in the 4th week. As a result of impression cytology, no change in conjunctival cell morphology was observed before and after injection. In conclusion, essential blepharospasm and dry eye are two independent diseases, but they can occur simultaneously. Botulinum toxin A injection is a very effective method in the treatment of blepharospasm. Although it has been stated in different studies that it has a positive effect on dry eye syndrome, it was observed that it did not have such an effect in our study.
The first record of Xerocomus silwoodensis (Boletaceae) in Ukraine
Authors:   Facebook group ", Martyniuk P.Y. ,   Fungi of Ukraine", Prylutskyi O.V. ,   V.N. Karazin Kharkiv National University, 4 Svobody Sq., Kharkiv 61077, Ukraine, Marques G. ,   CITAB-University of Tras-os-Montes and Alto Douro, Quinta de Prados, 5000-801 Vila Real, Portugal
Published: May 2024

Xerocomus silwoodensis is reported for the first time in Ukraine. For the specimens collected in Khmelnytskyi Region, descriptions of the macro- and microstructures and results of the ITS barcoding are provided. The authors also discuss differences between X. silwoodensis and related species of Xerocomus s. str. (X. ferrugineus, X. subtomentosus, and X. chrysonemus).
Nosocomial Infections in the Neonatal Intensive Care Unit
Authors: Marty Daisy , Sorum Kirsten , Smith Kevin , Nicoski Pamela , Sayyed Ban Al , Amin Sachin
Published: May 2024

Nosocomial infections are relatively common in the NICU. These infections increase morbidity and mortality, particularly in the smallest and most fragile infants. The impact of these infections on long-term outcomes and health-care costs is devastating. Worldwide efforts to decrease the incidence of nosocomial infections have focused on implementing specific prevention protocols such as handwashing, central line teams, care bundles, and antimicrobial stewardship. This review summarizes common nosocomial infections in patients in the NICU.
El lugar del diccionario representativo en la Lexicografía regional del español. Teoría y práctica.
Authors: Ahumada Ignacio
Published: May 2024

El llamado diccionario regional representativo queda encuadrado dentro de la cada vez más extensa tipología sobre los diccionarios regionales del español (diferenciales e integrales, fundamentalmente). Se trata de un modelo de repertorio que registra no solo el léxico diferencial con el estándar, sino también aquellas voces de la lengua general que representen para el hablante parte de su identidad lingüística y cultural en tanto este se identifica plenamente con su variedad geolectal. La propuesta recoge, en parte, criterios de selección léxica patentes en los tradicionales diccionarios de regionalismos (zoónimos y fitónimos) o bien lexicalizaciones determinadas por la aceptación social de determinados fenómenos fonéticos, etc. y, en cuanto a la microestructura, la organización del artículo en tres bloques perfectamente diferenciados: información lingüística, glosa pluridisciplinar y referencia onomasiológica.
Children with gene defects are a risk group for the development of abnormalities of the cardiovascular system
Authors:   Bogomolets National Medical University, Kyiv, Ukraine, Selska Z.V. , Vasylkova I.V. ,   Bogomolets National Medical University, Kyiv, Ukraine
Published: May 2024

To date, the prevalence of congenital heart defects (CHD), the level of disability and mortality from them in children remains an unsolved problem in pediatrics, despite the improvement of preventive measures, diagnostics and treatment in pediatric cardiology. There are a number of genetic diseases that are manifested by congenital anomalies of the cardiovascular system. Purpose - to analyze the abnormalities of the cardiovascular system in children with gene defects for the early diagnosis of genetic diseases in patients and the detection of congenital pathology of the heart and blood vessels in them, followed by their treatment tactics. This article describes a number of genetic syndromes in children, in which congenital anomalies of the heart and blood vessels are the most common. The characteristics of each of the syndromes include its definition, clinical symptoms with an emphasis on the external signs of the patient, the study of abnormalities of the cardiovascular system in this genetic disease, the examination plan for the patient and genetic testing used for the accuracy of the diagnosis. Conclusions. Based on the results of our analysis, we can conclude that there is a certain regularity between genetic diseases in children and the development of CHD in them, according to which certain CHD are formed with certain gene defects. Knowledge of the main clinical symptoms, especially external dysmorphism, in such patients helps in faster diagnosis and treatment of a genetic disease, in particular CHD. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.
The effect of chronic НBsAg carriage on the course of pregnancy, childbirth and the functional state of the liver of women with hepatitis B virus
Authors:   Ivano-Frankivsk National Medical University, Ukraine, Kurtash N.Ya. , Kravchuk I.V. ,   Ivano-Frankivsk National Medical University, Ukraine, Lasytchuk O.M. ,   Ivano-Frankivsk National Medical University, Ukraine, Kusa O.M. ,   Ivano-Frankivsk National Medical University, Ukraine, Kinash N.M. ,   Ivano-Frankivsk National Medical University, Ukraine
Published: May 2024

The problem of the hepatitis B virus (HBV) in pregnant women is complex and insufficiently studied, although it complicates the course of pregnancy and childbirth and worsens the perinatal consequences. It is important to conduct a multifocal examination of pregnant women with HBV with an assessment of the functional state of the liver, fetoplacental complex to minimize pathological conditions in the woman and the fetus. Purpose - to retrospectively analyze the epidemiological, clinical, and laboratory characteristics of pregnant women with HBV; to identify any effects of viral infection on liver function, pregnancy, delivery, and early perinatal outcomes. Materials and methods. A retrospective analysis was conducted with a comprehensive assessment of clinical and laboratory examinations of 320 pregnant women, who were divided into 2 groups: the Group I - 180 pregnant women with HBV, the Group II - 140 women with a physiological course of pregnancy. The anamnesis, clinical laboratory and instrumental studies of the functions of the liver, placenta and the course of pregnancy were evaluated. Results. In pregnant women of the Group ІІ, the pathology of the gastrointestinal tract was at the level of 33.89%, gestosis of the first half of pregnancy - 27.22%, anemia of pregnancy - in 17.22% and the threat of abortion - in 15.00%, signs of the placental dysfunction were diagnosed in 51.67% of women. In the second half of pregnancy, preeclampsia was diagnosed in 19.44%, and the threat of premature birth - in 27.22%, anomalies of labor activity (22.78%), uterine bleeding (10.55%) and untimely discharge of amniotic fluid were three times higher (50.55%), fetal distress developed in 6.11% of cases. In women of the Group I, intranatal asphyxia developed in 13.88%, intrauterine fetal development delay in 2.60%, the morbidity of infants was at the level of 23.33% (р<0.005), in particular, hypotrophy (8.88%), hemorrhagic syndrome (3.33%) and hyperbilirubinemia (11.11%). In the postpartum period, 20.00% had inflammatory complications. Conclusions. The hidden course of HBV during pregnancy leads to negative antenatal consequences. Changes in the indicators of the main functions of the liver were detected, which in turn can lead to disability. The research was carried out in accordance with the principles of the Declaration of Helsinki. The research protocol was approved by the Local Ethics Committee of all institutions mentioned in the work. Informed consent of the women was obtained for the research. No conflict of interests was declared by the authors.
Clinical features of the course of Hirschsprung’s disease in newborns and infants with consideration of the extent of colonic aganglionosis
Authors:   Bogomolets National Medical University, Kyiv, Ukraine, Prytula V.P. ,   National Children’s Specialized Hospital OKHMATDYT, Kyiv, Ukraine, Kurtash O.O. ,   Ivano-Frankivsk National Medical University, Ukraine, Rybalchenko V.F. ,   Shupyk National Healthcare University of Ukraine, Kyiv, Hussaini S.F. ,   Bogomolets National Medical University, Kyiv, Ukraine,   National Children’s Specialized Hospital OKHMATDYT, Kyiv, Ukraine
Published: May 2024

The clinical course of Hirschsprung’s disease (HD) in newborns and infants depends on the extent of сolonic aganglionosis, the age of patient, the presence of associated malformations and complications. The aim - to study the peculiarities of the clinical course of HD in newborns and infants. Materials and methods. An analysis of the clinical course of HD in 483 in newborns and infants. There were 100 (20.71%) patients with the rectal, 192 (39.75%) with rectosigmoid, 150 (31.05%) with subtotal, and 41 (8.49%) with total form of HD. 98 (20.29%) patients were found to have associated malformations. Results. 64 (13.25%) patients with a rectal form, 72 (14.91%) - with rectosigmoid, 150 (31.05%) - with subtotal, and 41 (8.49%) with total form had an acute clinical course and subacute clinical course was observed in 36 (7.45%) patients with rectal and 120 (24.85%) with rectosigmoid forms of HD. 327 (67.70%) infants with HD were diagnosed with varying degrees of hypotrophy, 315 (65.22%) had HD-associated enterocolitis, 16 (3.31%) had toxic megacolon, and 241 (49.89%) patients had varying degrees of anemia. Conclusions. In the presence of associated malformations in newborns and infants, in 8.07% of cases, clinical symptoms may prevail over the classic signs of HD. The severity of the course and late diagnosis are the main reasons for the appearance of severe complications of HD in newborns and infants - hypotrophy (67.70%), HD-associated enterocolitis (65.22%), toxic megacolon (3.31%) and anemia (49.89%). The research was carried out in accordance with the principles of the Declaration of Helsinki. The research protocol was approved by the Local Ethics Committee of all institutions mentioned in the work. Informed consent of the children’s parents was obtained for the research. No conflict of interests was declared by the authors.
Allergic diseases in children: a modern view on the problem
Authors:   SI Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova of the NAMS of Ukraine, Kyiv, Buratynska А.А. , Umanets T.R. ,   SI Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova of the NAMS of Ukraine, Kyiv
Published: May 2024

Aim: review of modern data of scientific medical literature regarding the prevalence, comorbidity, risk factors, features of pathogenesis, diagnosis, principles of treatment and prevention of allergic diseases in children. In recent years, the number of allergic diseases (ADs) has been increasing, especially among children. Approximately 20% of the world's population suffers from these diseases. Comorbid ADs are quite common. Thus, in 67–85% of children, allergic rhinitis is combined with bronchial asthma. Children with atopic dermatitis are diagnosed with allergic rhinitis in 61,8% of cases, and bronchial asthma in 29,4% of cases. The risk of developing bronchial asthma or allergic rhinitis is higher in children with food polysensitization, and infants and young children with atopic dermatitis have a high risk of developing both food allergy and asthma and allergic rhinitis. According to modern data, most ADs have common causal mechanisms. In the development and progression of asthma and allergic rhinitis and atopic dermatitis, the hypotheses of mechanistic damage of the epithelial barrier and biodiversity, related to each other, are considered. In ADs, mechanisms related to allergen-specific immunoglobulin E and non-allergic coexisting mechanisms play an important role. In addition, views on the formation of the sequence of the development of ADs ("allergic march") from the perspective of multimorbidity and phenotyping are increasingly expanding. Pathogenetic treatment of ADs is aimed at controlling the chronic T-helper 2, caused by the inflammatory process in target organs. Secondary and tertiary prevention of ADs in the early stages improves the quality of life of patients and improves the course of atopic conditions. Conclusions. The prevalence of ADs in modern conditions is pandemic in nature. The hypothesis of mechanical damage to the epithelial barrier is significant in the development of ADs. ADs, in particular in children, can be combined, creating multi- and comorbid conditions, and aggravate the course of these diseases. Timely diagnosis of ADs is important, and a personalized approach to the treatment and prevention of ADs is considered the most rational.
The SWOT Analysis of Halal Industry in Indonesia: NVIVO Study and Literature Review
Authors: Rohmadi Rohmadi , Bagaskara Doni Yusuf , Hikmah Ulvi Faiqotul
Published: May 2024

This study aims to determine the SWOT analysis of the halal industry in Indonesia using a mix method, namely the NVIVO analysis method and literature review studies. Research samples are news articles from trusted sources and national and international journals. From the study results, it was found that the words halal, industry, Indonesia, and product became the dominant words appearing in the discussion of the halal industry. There are four main topics discussed, namely strengths, weaknesses, opportunities, and challenges of the halal industry. The strongest relationship occurs between the challenges of the halal industry and the strength of the halal industry (0.840396), and the weakest between the opportunities of the halal industry and the challenges of the halal industry (0.542586). The results of the literature review show that the strengths and opportunities outweigh the weaknesses and challenges so that the halal industry in Indonesia is feasible to run. The implication of this study is to provide an overview of the topic of the halal industry and the feasibility of the halal industry in Indonesia. It is expected to be used as a reference for prospective entrepreneurs in the halal industry and related policy stakeholders to maximize the halal industry in Indonesia.
Lost Treasure
Authors: Perkins Blake
Published: May 2024

At the outset of the twentieth century malnutrition plagued the working people of Britain and their families. Their cooking skills had deteriorated and many of them relied on street vendors for most of their food. Successive governments and the medical establishment ignored evidence of the problem. Through the adaptation and innovation of social welfare practices a number of organisations and people including Florence Petty sought to alleviate the suffering of the working poor. Petty taught women to cook in their homes, established educational pilot programs, lectured extensively to raise awareness of the problem and became one of the leading broadcasters in the early years of BBC radio.
Alpha-gal syndrome: when treatment of hypovolemic shock can lead to anaphylaxis
Authors: Nalin Francesca , Scarmozzino Rocco , Arcolaci Alessandra , Olivieri Bianca , Tommasi Marina , Bonadonna Patrizia , Zanoni Giovanna
Published: May 2024

Delayed anaphylaxis after ingestion of red meat because of galactose-alpha-1,3-galactose (alpha-gal) syndrome has increased in recent years. The mechanism involves an immunoglobulin E reaction to alpha-gal, a molecule found in mammalian meat, dairy products, medications and excipients containing mammalian-derived components, and tick salivary glycans. Sensitization occurs due to the bite of a lone star tick and the transmission of alpha-gal molecules into person's bloodstream. We describe a case of alpha-gal syndrome with severe food, drug, and perioperative allergy in which anaphylaxis with hypovolemic shock occurred immediately after an emergency surgical procedure, when a gelatin-containing drug was injected. This case study confirms that the clinical manifestations of alpha-gal syndrome could be different depending on the route of administration, with immediate reactions if an alpha-gal-containing drug is injected and delayed type allergic manifestations occurring several hours after oral intake. The purpose of this report is to highlight the importance of risk communication in case of exposure to medical products and surgical procedures of patients with alpha-gal syndrome and to encourage drug manufacturers to indicate clearly the origin of excipients in product literature.
Diagnosed Dementia in Adults Age 65 and Older: United States, 2022
Authors: Kramarow Ellen A.
Published: May 2024

This report provides health data from the National Center for Health Statistics.
La protesta social narrada en los contradiscursos de los medios comunitarios y los medios privados
Authors:   FLACSO - Ecuador, CERBINO Mauro , PANCHI Marco ,   FLACSO - Ecuador
Published: May 2024

En el paro nacional de junio de 2022 en Ecuador, los medios de comunicación fueron escenario de discursos confrontados respecto a la movilización. Los medios comunitarios, a diferencia de los privados, se aliaron a las posturas de los manifestantes. Esta reflexión teórico-analítica aborda dos particularidades que se evidenciaron en las prácticas de los medios comunitarios, la relación medio-espacio y la configuración de los discursos, para evaluar la potencia de estos medios de sostener propuestas distintas y más responsables de comunicación, sobre todo en contextos de alta conflictividad social.
El bienestar común de los estudios de la comunicación o regresemos al humanismo desde la comunalidad universitaria
Authors:   Universidad Autónoma de la Ciudad de México, MARTÍNEZ MATÍAS Graciela
Published: May 2024

En territorios de los pueblos originarios de Oaxaca, México, se construye desde la filosofía de la comunalidad, la Universidad Autónoma Comunal de Oaxaca (UACO), con apuestas epistémicas, teóricas y metodológicas distintas a las universidades tradicionales. Los entornos sonoros, la historiografía subalterna y las poéticas narrativas en la investigación, además de la acción de la escucha, cruzan el modelo universitario territorial de la comunalidad. Este artículo es un acercamiento a la UACO para conocer métodos, teorías y estrategias propias (desde la cosmovisión comunal). que puedan retomarse desde los Estudios de la Comunicación en México para genera líneas de investigación y narrativas audiovisuales próximas al humanismo, la comunalidad y la microhistoria. Floriberto Hernández, Jaime Luna Martínez, Ranajit Guha y Didier Eribon son parte del marco teórico que sustenta este trabajo. Los métodos documental y biográfico, y la técnica de la entrevista semiestructurada fueron utilizados para la obtención de la información.
COST ESTIMATION MODEL FOR HIGHWAY PROJECTS USING ANN
Authors: Gurung Lily , Chhetri Manoj
Published: May 2024

Construction and maintenance works are carried out by contractors for a period of few months to few years. Those contracts show cost variations between the actual and estimated costs. For example, cost estimation of 3 out of 5 projects from 2015- 19 in Trashigang Dzongkhag have not only been underestimated but the actual costs are on average 27% higher than the estimated costs. Moreover, researches reveal that there are issues in cost estimation at the conceptual stage affecting the project progress and cost (Flyvberg, 2002). In this study neural network has been used to predict the actual cost based on the initial estimation and duration. During the study, it was discovered that the neural network demonstrated its usefulness as a tool for cost estimation and could be effectively employed by decision makers. However, it is important to note that the neural network is not designed to replace the entire cost estimation method. Instead, it should be regarded as one of the tools to be utilized alongside other methods when estimating costs.