bluuebunny/crossref_metadata_2025 huggingface dataset:
The Impact of an Acute Active Reading Intervention on Physical Activity Levels in Preschoolers: A Comparative Analysis
Authors: Wadsworth Danielle D. , Spring Katherine E.
Published: February 2024

The purpose of this study was to examine the acute effects of an active reading intervention on physical activity (PA) levels in preschoolers. Participants were recruited from the 3–5-year-old classes at two preschools. A total of six classrooms and 37 children participated in three conditions: an active reading book read by a researcher (Act_R) trained in active play techniques, an active reading book read by a preschool classroom teacher (Act_T), and a book about health behavior read by both the researcher and the teacher (Sed_H). The order in which classes received each condition was randomized. The Actigraph accelerometer assessed PA. Motor skills were assessed with the Peabody Motor Development Scale, 2nd Edition. Participants spent significantly more time in sedentary behavior during the Sed_H condition compared to Act_R (p < 0.000) and Act_T (p < 0.008). Participants spent significantly more time in MVPA during Act_R compared to Act_T (p = 0.030), Act_T compared to Sed_H (p < 0.001), and Act_R compared to Sed_H (p < 0.001). The amount of MVPA participation within the active reading sessions was not dependent upon the level of fundamental motor skill competence. Active reading books may provide a feasible method to incorporate physical activity and active play into the preschool day.
Parasympathetic Nervous System Functioning Moderates the Associations between Callous-Unemotional Traits and Emotion Understanding Difficulties in Late Childhood
Authors: Lynch Sarah F. , Perlstein Samantha , Ordway Cora , Jones Callie , Lembcke Hanna , Waller Rebecca , Wagner Nicholas J.
Published: February 2024

Background: Callous-unemotional (CU) traits are characterized by low empathy, guilt, and prosociality, putting children at risk for lifespan antisocial behavior. Elevated CU traits have been linked separately to difficulties with emotion understanding (i.e., identifying emotional states of others) and disrupted parasympathetic nervous system (PNS) functioning. However, no study has investigated how PNS functioning and emotion understanding are jointly related to CU traits. Method: We explored associations between CU traits, emotion understanding, and PNS functioning (indexed via respiratory sinus arrhythmia [RSA]) among children aged 7–10 years old (n = 55). We also tested whether deficits in emotion understanding differ across specific emotions (i.e., fear, pain, happiness, anger). Each child’s RSA was continuously recorded while they watched a film that included emotionally evocative social interactions. To assess emotion understanding, children identified emotions replayed in 1s animations of scenes from the film. Parents reported on child CU traits, conduct problems, and demographic information. Results: Higher CU traits were related to lower emotion understanding (β = −0.43, p = 0.03). PNS activity during the film moderated this association (β = −0.47, p < 0.001), such that CU traits were associated with lower emotion understanding among children with mean (B = −0.01, t = −2.46, p = 0.02) or high (i.e., 1 SD > M; B = −0.02, t = −3.00, p < 0.001) RSA levels during the film, but not among children with low RSA levels (i.e., 1 SD < M; B = 0.00, t = −0.53, p = 0.60). Moreover, we found that the observed moderated associations are driven by deficits in fear, specifically. Conclusions: The link between poorer emotion understanding, fear understanding in particular, and CU traits was attenuated for children who demonstrated patterns of PNS functioning consistent with attentional engagement while viewing the emotion stimuli.
Approaches to Measuring Beta Cell Reserve and Defining Partial Clinical Remission in Paediatric Type 1 Diabetes
Authors: Kennedy Elaine C. , Hawkes Colin P.
Published: February 2024

Context: Type 1 diabetes (T1D) results from the autoimmune T-cell mediated destruction of pancreatic beta cells leading to insufficient insulin secretion. At the time of diagnosis of T1D, there is residual beta cell function that declines over the subsequent months to years. Recent interventions have been approved to preserve beta cell function in evolving T1D. Objective: The aim of this review is to summarise the approaches used to assess residual beta cell function in evolving T1D, and to highlight potential future directions. Methods: Studies including subjects aged 0 to 18 years were included in this review. The following search terms were used; “(type 1 diabetes) and (partial remission)” and “(type 1 diabetes) and (honeymoon)”. References of included studies were reviewed to determine if additional relevant studies were eligible. Results: There are numerous approaches to quantifying beta cell reserve in evolving T1D. These include c-peptide measurement after a mixed meal or glucagon stimuli, fasting c-peptide, the urinary c-peptide/creatinine ratio, insulin dose-adjusted haemoglobin A1c, and other clinical models to estimate beta cell function. Other biomarkers may have a role, including the proinsulin/c-peptide ratio, cytokines, and microRNA. Studies using thresholds to determine if residual beta cell function is present often differ in values used to define remission. Conclusions: As interventions are approved to preserve beta cell function, it will become increasingly necessary to quantify residual beta cell function in research and clinical contexts. In this report, we have highlighted the strengths and limitations of the current approaches.
Key Questions on the Long-Term Utility of Methylphenidate in Paediatric Brain Tumour Survivorship: A Retrospective Clinical Case Series
Authors: Hagan Alexander J. , Verity Sarah J.
Published: February 2024

Methylphenidate has an established role in the management of attention-deficit hyperactivity disorder and attentional deficit secondary to brain injury. Increasingly, methylphenidate is considered for the attentional deficit in paediatric brain tumour survivors. A small number of studies have explored the benefit of methylphenidate in this population; however, studies are of short duration and do not address the impact of medium to long-term use of methylphenidate on intellectual function. We identified six patients who are survivors of a paediatric brain tumour aged 12–18 years with greater than three years of use of methylphenidate for inclusion in a clinical case series. We used this patient cohort to identify key questions to inform a future long-term cohort study. Linear mixed model and reliable change index analyses were performed on the data. Reliable change index analyses showed benefits to working memory (n = 3), processing speed (n = 2), and full-scale IQ (n = 4) performance for some patients. This exploratory case series suggests the potential medium to long-term benefit of methylphenidate in brain tumour survivorship, indicating the need for larger, appropriately powered studies. These patient data, alongside a discussion of learning points from our previously published studies, are used as a conduit for the identification of questions relating to the use of methylphenidate in a paediatric brain tumour.
Examining the Prevalence of Congenital Anomalies in Newborns: A Cross-Sectional Study at a Tertiary Care Maternity Hospital in Saudi Arabia
Authors: Narapureddy Bayapa Reddy , Zahrani Yousef , Alqahtani Hind Eissa Musa , Mugaiahgari Bharat Kumar Mamilla , Reddy Lingala Kalyan Viswanath , Mohammed Asif Shaik , Almoyad Mohammad Ali Abdullah , Mohieldin Ali , Dawria Adam
Published: February 2024

Background: Congenital anomalies, representing structural or functional abnormalities present at birth, pose a substantial global health challenge, affecting 8 million newborns annually. With 3.3 million succumbing before age five and 3.2 million facing physical or mental disability, their diverse causes necessitate comprehensive understanding for effective healthcare planning. This study explores the prevalence of congenital anomalies among newborns in the Abha Maternity and Children Hospital (MCH) in Abha, Kingdom of Saudi Arabia. Methodology: A descriptive cross-sectional record-based study was conducted on newborns born between 2018 and 2022. Data were gathered in 4 months from September to December 2023. Purposive sampling was employed to select the case records of newborns with congenital anomalies after careful screening and considering inclusion and exclusion criteria. Data was acquired through a self-designed study tool, and the data were entered into Google Forms. Results: Congenital anomalies’ five-year prevalence was 3.21%, and one year, in 2022, the prevalence was 4.02%. Female neonates exhibited higher anomalies (59.3%), and preterm births accounted for 39.6%, emphasizing their vulnerability. The findings indicate that consanguineous marriages are linked to 63.3% of anomalies, notably neural tube defects (25%) and congenital heart diseases (19.7%). Anomalies are not significantly associated with consanguinity or birth order, but maternal age, education, employment, and antenatal maternal medical issues are associated considerably. Conclusions: These study insights contribute to health planners planning targeted interventions and awareness programs that are crucial to mitigate risks associated with preterm births and consanguineous marriages. The promotion of 100% antenatal screening and prophylactic medication for high-risk women and couples is necessary to prevent inherited deformities. In future the Ministry of Health must plan large-group prospective research to better understand the associated risk factors that will help public health initiatives minimize congenital-associated neonatal mortality and improve pregnancy outcomes.
Extremely Cold Climate and Social Vulnerability in Alaska: Problems and Prospects
Authors: Grigorieva Elena A. , Walsh John E. , Alexeev Vladimir A.
Published: February 2024

Cold exposure remains a significant public health concern, particularly in the Arctic regions prone to extremely cold weather. While the physical health impacts of cold exposure are well documented, understanding the social vulnerability aspects is crucial for effective mitigation and policy development. This study investigates the multifaceted dimensions of social vulnerability in the face of cold temperatures across various communities in Alaska. Alaska, renowned for its extreme cold temperatures and harsh environmental conditions, poses unique challenges to its residents, particularly in the context of social vulnerability. Drawing on a combination of quantitative data analysis and qualitative insights, we examine the factors contributing to social vulnerability, including demographic, economic, geographic, and infrastructural elements, in terms of the Extremely Cold Social Vulnerability Index, for seven Public Health Regions in Alaska. The Universal Thermal Climate Index in two very cold categories (<−27 °C) was used to identify cold exposure. Factors such as income, housing quality, health status, and resilience of the population play crucial roles in determining an individual or community’s sensitivity to, and ability to cope with, cold temperatures. Our analysis reveals that social vulnerability in Alaska is not uniform but varies significantly among regions. The research findings highlight the importance of considering factors of both sensitivity and adaptivity in understanding and addressing social vulnerability, thereby informing the development of targeted strategies and policies to enhance the resilience of Alaskan communities. As cold temperatures are projected to continue to challenge the region, addressing social vulnerability is essential for ensuring the well-being and safety of Alaska’s diverse populations.
Preparation and Self-Cleaning Properties of a Superhydrophobic Composite Coating on a Stainless Steel Substrate
Authors: Li Fengqin , Hu Yuxue , Feng Xiaoming , Tian Guizhong
Published: February 2024

In order to improve the anti-fouling of stainless steel surfaces in outdoor or humid environments, a superhydrophobic modification is often used to improve its self-cleaning performance. However, the mechanical stability of superhydrophobic surfaces remains a challenge. In this paper, a two-step preparation method was adopted to prepare the micro–nanocomposite coating, which innovatively combined “top-down” and “bottom-up” approaches, and also coupled together two key factors that affect superhydrophobicity: a rough microstructure, and low surface energy. The silver mirror, adhesion, and pollution-resistance results show that the composite coating samples, which were obtained by optimizing the preparation process, have excellent water repellency and self-cleaning properties. Meanwhile, the samples demonstrate outstanding mechanical stability, and can resist damage from sandpaper and tape. The two-step preparation method was simple, fast, and efficient. This method could be popularized and applied to the preparation of superhydrophobic surfaces on metal substrates.
Dielectric Behavior of Stretchable Silicone Rubber–Barium Titanate Composites
Authors: Drymiskianaki Argyri , Katsara Klytaimnistra , Manousaki Alexandra , Viskadourakis Zacharias , Kenanakis George
Published: February 2024

In this study, elastomer composites, including silicone rubber and barium titanate, were fabricated by mechanical mixing, a low-cost, fast, and easy technique to produce highly dielectric materials. The resulting composites were investigated in terms of their dielectric and mechanical properties in terms of filler percentage in the mixture. Dielectric permittivity measurements were taken using the microwave regime, and uniaxial tensile tests were carried out for the study of the materials’ mechanical properties, while combined experiments were also carried out to investigate potential correlations between them. The experimental results show that barium titanate inclusions in silicone matrix significantly improve the dielectric constant while reducing the mechanical properties of composites. In addition, combined experiments show that the composites exhibit a nearly stable dielectric profile under mechanical deformations. Consequently, mechanically mixed barium titanate–silicone elastomer composites could potentially become a cost-effective alternative in the extensive market for insulating materials and flexible electronics.
Ab Initio Study on the Vibrational and Electronic Properties of Radiation-Induced Defects in Potassium Bromide
Authors: Platonenko Alexander , Pankratov Vladimir , Kotomin Eugene A. , Dauletbekova Alma , Popov Anatoli I.
Published: February 2024

The vibrational and electronic properties of several basic radiation defects in potassium bromide are computed at the quantum mechanical level using a periodic supercell approach based on hybrid functionals, an all-electron Gaussian-type basis set, and the Crystalcomputer code. The exciton energy in alkali halides is sufficient to create lattice defects, such as F–H Frenkel defect pairs, resulting in a relatively high concentration of single defects and their complexes. Here, we consider eight defects: the electronic F+- and F-centers (bromine vacancy without and with trapped electrons) and their dimers; hole H-center (neutral bromine atom forming the dumbbell ion with a regular Br− ion.); VK-center (Br2− molecular ion consisting of a hole and two regular ions); and two complex Br3− defects, combinations of several simple defects. The local geometry and the charge- and spin-density distributions of all defects are analyzed. Every defect shows its characteristic features in Raman spectra, and their comparison with available experimental data is discussed.
The Bidirectional Relationship between Sleep and Neurodegeneration: Actionability to Improve Brain Health
Authors: Ibrahim Abubaker , Högl Birgit , Stefani Ambra
Published: February 2024

Recently, it has become increasingly clear that there is a bidirectional relationship between sleep/circadian rhythms and neurodegeneration. Knowledge about this topic further improved after the description of the glymphatic system, which is mainly active during sleep. Changes in sleep and circadian rhythms are present not only in overt neurodegenerative diseases but also in their early, prodromal, and preclinical phases, supporting that they precede (and contribute to) the development of neurodegeneration. This narrative review provides a brief overview of sleep and circadian rhythm disruption in neurodegeneration, highlights the bidirectional relationship between sleep changes and neurodegeneration, and addresses future perspectives, in particular, whether sleep changes are able to predict neurodegeneration and the potential sleep actionability to prevent or modulate the development of neurodegenerative diseases.
Electric and Magnetic Fields Analysis of the Safety Distance for UAV Inspection around Extra-High Voltage Transmission Lines
Authors: Boukabou Issam , Kaabouch Naima
Published: February 2024

The deployment of small unmanned aerial vehicles (UAVs), or drones, for transmission line inspections, has brought attention to the potential impact of electromagnetic fields (EMFs) on UAV operations. This work describes a mathematical model based on the finite elements method (FEM), designed to examine the electric and magnetic fields produced by extra-high voltage (EHV) conductors. The current study extends the analysis to encompass both electric and magnetic fields and evaluates the safe distances for UAVs operating near 345 kV, 500 kV, and 765 kV transmission lines. The electromagnetic environment around these EHV transmission lines was simulated using electrostatic, magnetostatic, and transient magnetic modules within the QuickField software 6.6. Electric and magnetic profiles were estimated using 2D finite element analysis, including a numerical simulation for phase-to-phase fault EMFs for the above transmission lines. These results were then cross-verified with theoretical calculations at specific intervals and further validated using the EMFACDC analytical method developed by the International Telecommunication Union. This comprehensive assessment concludes that precise distance considerations are necessary to ensure UAV safety during power line inspections, mitigating potential risks from EMF interference.
Implementation of Biotechnology Applied to Medicine Course Using Virtual Laboratories: Perceptions and Attitudes of Students
Authors: Zamora-González Edgar Oswaldo , Herráez Angel , Gutiérrez-Muñoz Paula Daniela , Torres-Bugarín Olivia , Toral-Murillo María Valentina , Gómez-Díaz Benjamín , Calderón-Reyes Cecilia Adriana , Vázquez-Cárdenas Norma Alejandra , Marín-Cruz Antonio , Rodríguez-Baeza Marcela María José , Lara-Palazuelos Nathaniel , López-Hernández Luz Berenice
Published: February 2024

The rapid evolution of biotechnology across various sectors, including agriculture, industry, and medicine, has profoundly transformed our comprehension of the world. Virtual laboratories (VLs) provide an immersive learning experience that can enhance future generations’ understanding of biotechnology’s medical applications. This study investigated the impact of incorporating VLs into a short course on biotechnology applied to medicine on the attitudes and perceptions of third-year medical students (n = 210). A validated questionnaire was employed to assess their perspectives, attitudes, and experience with virtual laboratory platforms before and after the course. The findings revealed a significant positive change in 7/38 questionnaire items (p < 0.05), indicating that the VL experience modified perceptions about biotechnology. This study emphasizes the importance of exploring innovative teaching methods for biotechnology and highlights the advantages of VL in educating future physicians. The primary concerns of the students were the misuse of personal genetic information and biotechnological applications involving animal modification. Overall, the students had a favorable experience using the virtual laboratory platforms. These findings collectively suggest that VL can positively influence perceptions and attitudes toward biotechnology among healthcare professionals.
Liquid Crystal-Filled 60 GHz Coaxially Structured Phase Shifter Design and Simulation with Enhanced Figure of Merit by Novel Permittivity-Dependent Impedance Matching
Authors: Li Jinfeng , Li Haorong
Published: February 2024

This work serves as the first simulation investigation to tackle the liquid crystal (LC)-filled coaxially structured continuously variable phase shifter at 60 GHz, wherein the LCs act as single tunable dielectrics fully occupying the millimeter-wave (mmW) power transmitted (i.e., free of leakage or interference). Impedance and effective dielectric constant computations are settled, followed by the quantification of the interplay between the dielectric thickness and the dielectric constant (Dk) for a controlled 50 Ω impedance. Geometry’s aspect ratio (AR) effects are exploited for the coaxially accommodating topology filled with mmW-tailored LCs with an operatable Dk range of 2.754 (isotropic state) to 3.3 (saturated bias state). In addition to the proposed structure’s noise-free advantages, a novel figure of merit (FoM) enhancement method based on Dk-selection-based impedance matching is proposed. The optimum FoM design by simulation exhibits a 0–180.19° continuously variable phase shift with a maximum insertion loss of 1.75871 dB, i.e., a simulated FoM of 102.46°/dB when the LC-filled coaxial geometry is 50 Ω and matched with the Dk of 2.8, corresponding to the dielectric thickness of 0.34876 mm and line length of 15.92 mm. The envisioned device fabrication and assembly processes are free of the conventional polyimide alignment agent and the related thermal and electrical concerns. Significant cost reduction and yield improvement can hence be envisaged. The topology can also serve as a test structure for broadband characterizations of LC materials and new electro-optical effects.
A Pedestrian Trajectory Prediction Method for Generative Adversarial Networks Based on Scene Constraints
Authors: Ma Zhongli , An Ruojin , Liu Jiajia , Cui Yuyong , Qi Jun , Teng Yunlong , Sun Zhijun , Li Juguang , Zhang Guoliang
Published: February 2024

Pedestrian trajectory prediction is one of the most important topics to be researched for unmanned driving and intelligent mobile robots to perform perceptual interaction with the environment. To solve the problem of the SGAN (social generative adversarial networks) model lacking an understanding of pedestrian interaction and scene constraints, this paper proposes a trajectory prediction method based on a scenario-constrained generative adversarial network. Firstly, a self-attention mechanism is added, which can integrate information at every moment. Secondly, mutual information is introduced to enhance the influence of latent code on the predicted trajectory. Finally, a new social pool is introduced into the original trajectory prediction model, and a scene edge extraction module is added to ensure the final output path of the model is within the passable area in line with the physical scene, which greatly improves the accuracy of trajectory prediction. Based on the CARLA (CAR Learning to Act) simulation platform, the improved model was tested on the public dataset and the self-built dataset. The experimental results showed that the average moving deviation was reduced by 26.4% and the final offset was reduced by 23.8%, which proved that the improved model could better solve the uncertainty of pedestrian turning decisions. The accuracy and stability of pedestrian trajectory prediction are improved while maintaining multiple modes.
Oxidative Stability and Pasting Properties of High-Moisture Japonica Brown Rice following Different Storage Temperatures and Its Cooked Brown Rice Flavor
Authors: Qu Lingyu , Zhao Yan , Li Yanfei , Lv Haoxin
Published: February 2024

The study proposed to investigate the impacts of storage temperatures (15, 20, 25 °C) on the oxidative stability (peroxide value, carbonyl value, malondialdehyde content) and sensory attributes (pasting properties, cooked brown rice flavor) of high-moisture japonica brown rice. According to the findings, the peroxide value, the carbonyl value, and the malondialdehyde content of high-moisture japonica brown rice stored at a temperature of 15 °C exhibited consistently low levels, and the pasting properties were favorable. In addition, 22 out of 51 flavor volatiles were screened as key differential volatile flavor compounds in cooked brown rice via a combination of ANOVA and orthogonal projections to latent structures-discriminant analysis (OPLS-DA). Among them, 3-heptylacrolein had an aroma of fat and mushroom, and its contents were higher at 15 °C and 20 °C. These findings could serve as a valuable reference for storing high-moisture japonica brown rice under low temperature conditions as well as for investigating the flavor characteristics of cooked brown rice derived from this variety.
Measuring Pleasure from Food—Validation of the Food Pleasure Scale by Multiple Techniques and Mixed Methods
Authors: Hyldelund Nikoline Bach , Byrne Derek Victor , Dean Wesley , Squarzon Claudia , Andersen Barbara Vad
Published: February 2024

The development of scales and questionnaires to assess pleasure perception has gained prominence, particularly for evaluating anhedonia in mental disorders. The Food Pleasure Scale is a comprehensive tool exclusively dedicated to measuring pleasure perception from food and food-related experiences. This study aimed to evaluate the face validity and consistency reliability of the Food Pleasure Scale using a mixed methods approach. Twenty-two participants completed the Food Pleasure Scale questionnaire and participated in in-depth interviews to understand their interpretation of the scale items. The interview data underwent thematic analysis, and the quantitative survey data was compared to the qualitative interview responses. Results indicated a high level of understanding of all items in the Food Pleasure Scale, confirming its face validity and applicability. The mixed methods approach supported the consistency reliability, showing consistency between quantitative measures and participants’ explicit and implicit expressions of food pleasure. Furthermore, the study revealed a novel aspect related to food pleasure: the concept of “making an effort”. Overall, this study highlights the comprehensibility, validity, and potential of the Food Pleasure Scale in consumer studies. It effectively captures the subjective experience of pleasure derived from food and food-related encounters, making it a valuable tool for further research in this domain.
Effects of In Vitro Fermentation of Polysialic Acid and Sialic Acid on Gut Microbial Community Composition and Metabolites in Healthy Humans
Authors: Yin Zhongwei , Zhu Li , Gao Minjie , Yu Dan , Zhang Zijian , Zhu Ling , Zhan Xiaobei
Published: February 2024

The influence of polysialic acid (PSA) and sialic acid (SA) on the gut microbial community composition and metabolites in healthy humans was investigated using a bionic gastrointestinal reactor. The results indicated that PSA and SA significantly changed the gut microbiota and metabolites to different degrees. PSA can increase the relative abundances of Faecalibacterium and Allisonella, whereas SA can increase those of Bifidobacterium and Megamonas. Both can significantly increase the content of short-chain fatty acids. The results of metabolome analysis showed that PSA can upregulate ergosterol peroxide and gallic acid and downregulate the harmful metabolite N-acetylputrescine. SA can upregulate 4-pyridoxic acid and lipoic acid. PSA and SA affect gut microbiota and metabolites in different ways and have positive effects on human health. These results will provide a reference for the further development of PSA- and SA-related functional foods and health products.
A Novel, Controllable, and Efficient Method for Building Highly Hydrophobic Aerogels
Authors: Li Shu-Liang , Wang Yu-Tao , Zhang Shi-Jun , Sun Ming-Ze , Li Jie , Chu Li-Qiu , Hu Chen-Xi , Huang Yi-Lun , Gao Da-Li , Schiraldi David A.
Published: February 2024

Aerogels prepared using freeze-drying methods have the potential to be insulation materials or absorbents in the fields of industry, architecture, agriculture, etc., for their low heat conductivity, high specific area, low density, degradability, and low cost. However, their native, poor water resistance caused by the hydrophilicity of their polymer matrix limits their practical application. In this work, a novel, controllable, and efficient templating method was utilized to construct a highly hydrophobic surface for freeze-drying aerogels. The influence of templates on the macroscopic morphology and hydrophobic properties of materials was investigated in detail. This method provided the economical and rapid preparation of a water-resistant aerogel made from polyvinyl alcohol (PVA) and montmorillonite (MMT), putting forward a new direction for the research and development of new, environmentally friendly materials.
Health Professionals’ Perspectives on Commercially Available Intravenous Nutrient Therapies: A Preliminary Report
Authors: Karasiewicz Monika , Lipiak Agnieszka , Jóźwiak Paulina , Giernaś Bogusz , Cofta Mateusz , Chawłowska Ewelina
Published: February 2024

Background: Intravenous nutrient therapies (IVNTs) have gained popularity on the commercial market. Targeted at people with a variety of ailments and needs, the procedures allegedly offer numerous benefits and quick results, widely advertised on the websites of drip bars and health clinics as well as in the available literature. What is less often presented is the point of view of the customers of such services and the opinions of health personnel. Although the latter perspective seems to be crucial, little is known about it. Therefore, the purpose of this study was to present the opinions and experiences of health professionals (n = 188) on commercially available IVNTs dedicated to adults. Methods: The study was conducted between April 2019 and March 2020 by means of a survey using an ad hoc questionnaire made available mainly to health professionals attending public health postgraduate courses at the Poznan University of Medical Sciences, Poland. Results: As many as 91.5% of the respondents had heard of commercially available IVNTs (mostly from the media), and 47.3% knew of a facility offering such services. Among the possible situations where the use of IVNTs would be justified, the most commonly mentioned was a diagnosed nutrient deficiency (37.8%), while the least common ones were libido problems (1.1%) and the need to speed up metabolism (2.1%). For 25.5% of the respondents, there was no good rationale for using IVNTs. As many as 15.4% had no opinion on the subject. Health risks of IVNTs were recognised by 95.2% of professionals, with the biggest concerns being the lack of full information on patients’ health status and medical contraindications (84%), the risk of overdose and interactions (77.1%), and hypersensitivity or allergic reactions (75.5%). Among the reasons for IVNTs’ popularity, the respondents listed not only fads spread by celebrities and social media (89.4%) and the need for quick, effortless remedies (77.1%), but also reasons inherent in the Polish healthcare system. As many as 80.3% of the respondents stressed the need for public health institutions to take a stand on commercial IVNTs. Knowing of an IVNT facility was not significantly associated with the opinions of professionals in key areas. Conclusion: Postgraduate public health courses are a good opportunity to engage health professionals in discussions about the current challenges, trends, and needs in the area of health promotion and healthcare. This study’s findings shed some light on the opinions about IVNTs held by health professionals, who are important stakeholders of the healthcare system. Thus, these findings may help to better understand the popularity of IVNTs and incorporate health professionals’ perspectives in future efforts aiming to increase the awareness of IVNT-related health risks among both professionals and patients.
The Association between Women’s History of Sexual Abuse, Mental Health, and Sexual Motivations in Committed Intimate Relationships
Authors: Estlein Roi , Dror Ronit Smadar , Winstok Zeev
Published: February 2024

In committed intimate relationships, motivations for engaging in or avoiding sexual relations can indicate partners’ perceptions, needs, and attitudes toward sexual intimacy, and reflect sexual functioning. Sexual motivations can be positive, reflecting and advancing relational goals, such as establishing and maintaining closeness between partners and pleasure, or negative, stemming out of fear of one’s partner, pleasing them, or depriving sexual contact to punish the partner or establish relational power. In this study, we extended the current conceptualization and assessment of negative sexual motivations to explore the associations between women’s history of sexual abuse, their mental health, and their negative sexual motivations. Structural equation modeling results from 236 adult Israeli women who were in committed intimate relationships indicated that a woman’s history of sexual abuse negatively predicted her mental health which, in turn, negatively predicted her negative sexual motivations. Mental health mediated the association between a woman’s history of sexual abuse and her negative sexual motivations. These findings have theoretical and empirical contributions to research in terms of the short- and long-term effects of sexual abuse on women, mental health, and women’s sexuality. Their clinical implications for mental health professionals, sexual therapists, and clinicians working with women who experience sexual abuse are also discussed.
Pelvic Floor Dysfunction among Reproductive-Age Women in Israel: Prevalence and Attitudes—A Cross-Sectional Study
Authors: Fisher-Yosef Tehila , Lidsky Sachs Dina , Edel Shiri Sacha , Nammouz Hanan , Zoabi Abd Ellatif , Adler Limor
Published: February 2024

Objectives: Our study aimed to investigate the prevalence of female pelvic floor dysfunction (PFD) in Israeli women who experienced vaginal delivery and are in their reproductive years (premenopausal), as well as to understand their attitudes and health-seeking behavior and barriers towards treating this problem. Methods: In this cross-sectional study, we conducted a questionnaire-based Internet survey. The surveys were sent to Israeli women in their fertile years (18–50 years old). We asked the women about their PFD symptoms, attitudes, and help-seeking behaviors. We used two validated questionnaires, including the USIQ and the PFDI-20. The combined questionnaire was submitted in both Hebrew and Arabic. We assessed the prevalence of PFD symptoms in the study population. Symptomatic women were asked about their help-seeking behaviors and their beliefs, desires, and barriers regarding the clinical management of symptoms. Results: Between July and September 2020, 524 women completed the questionnaire (response rate 44%). In total, 95% reported at least one symptom (mostly urinary-related) at any grade of severeness in at least one category, and 66.8% suffered from at least one moderate to severe symptom in at least one category. Most women (93.7%) reported that they wanted to be asked and offered voluntary information about PFD from physicians and nurses; however, only 16.6% reported receiving such information. Barriers to seeking treatment were mainly related to low awareness. The study’s main limitation was selection bias due to the questionnaire’s design. Conclusions: These findings show the importance of raising awareness of the different therapeutic solutions to PFD symptoms and designing more available services for this common problem.
Factors Influencing Copulation Duration in Dastarcus helophoroides (Fairmaire) (Coleoptera: Bothrideridae)
Authors: Zhong Hui-Hui , Li Chao-Qun , Zhang Jiang-Tao , Wei Li-Feng , Liu Xing-Ping
Published: February 2024

The gregarious ectoparasitic beetle Dastarcus helophoroides (Fairmaire) is considered a primary biocontrol agent for controlling several cerambycid pests in East Asian countries. A thorough study of reproductive behavior is a prerequisite for the mass production of natural insect predators. Nonetheless, little attention has been given to this ectoparasitic beetle. We performed a series of trials to assess whether the adult copulation duration, a key behavioral trait, is differentially influenced by physiological and ecological factors, including body size, mating history, kinship, sex ratio, mating sequence, feeding status, ambient temperature, photoperiod, and time of day. Additionally, the effect of the copulation duration on the reproductive output of this beetle was also investigated. The results indicated that the copulation duration varied considerably, ranging from 1.12 min to 16.40 min and lasting for an average of 9.11 ± 0.12 min. Females with longer copulations laid more eggs and had a greater proportion of eggs hatched. Medium-sized individuals copulated significantly longer than small- and large-sized individuals. The copulation durations were significantly longer when both sexes experienced an asymmetric mating history than when both sexes experienced a symmetric mating history. Inbred couples copulated significantly longer than outbred couples. In terms of the adult sex ratio, increasing the density of females (polygamous group) or males (polyandrous group) led to significantly longer copulation durations than those in the monogamous group. The copulation durations gradually decreased with increasing the mating sequence and temperature. Food-absence couples copulated significantly longer than food-presence couples. The mean copulation duration of the scotophase was significantly longer than that of the photophase. These results demonstrate that all of the analyzed factors emerge as important factors influencing the copulation duration, ultimately affecting the reproductive outputs in this ectoparasitic beetle.
The Extraordinary Diversity of Merodon avidus Complex (Diptera: Syrphidae)—Adding New Areas, New Species and a New Molecular Marker
Authors: Vujić Ante , Kočiš Tubić Nataša , Radenković Snežana , Ačanski Jelena , Likov Laura , Arok Maja , Gorše Iva , Djan Mihajla
Published: February 2024

In this paper, the Merodon avidus (Diptera, Syrphidae) species complex was revised, whereupon we discovered and described four new species for science: Merodon atroavidus Vujić, Radenković et Likov sp. nov., M. magnus Vujić, Kočiš Tubić et Ačanski sp. nov., M. nigroscutum Vujić, Radenković et Likov sp. nov. and M. pseudomoenium Vujić, Kočiš Tubić et Ačanski sp. nov. An integrative taxonomy approach was used to delimit species boundaries. Two molecular markers (the mitochondrial COI gene and nuclear 28S rRNA gene—newly analysed marker for the complex) and geometric morphometry of the wing shape, together with morphological data and distribution, successfully separated all species from the complex. The morphological variability of the analysed species is described and discussed and an illustrated diagnostic key for typical morpho-forms of species from the M. avidus complex is presented. A distribution map of all investigated species from the complex is provided. The level of endemicity of the M. avidus complex was discussed.
The Skeletal Stability of Combined Surgery First Approach and Clear Aligners in Skeletal Class III Malocclusion Correction: A Randomized Controlled Trial
Authors: Li Meng , Shen Shunyao , Huang Jingyang , Wang Yiming , Bao Jiahao , Wang Bo , Yu Hongbo
Published: February 2024

The surgery first approach (SFA) and clear aligners technique can address traditional treatment defects, such as prolonged waiting times for surgery and a less desirable facial appearance due to wire aligners. However, the curative effect of the combination remains uncertain. The randomized controlled study aimed to evaluate the skeletal stability of the SFA compared to the conventional orthodontic first approach (OFA), both of which were applied with clear aligners. A total of 74 participants were randomly allocated to two groups: the SFA group (experimental) and the OFA group (control). The skeletal deviation was calculated using reconstruction models from computed tomography scans taken immediately and 6 months after surgery. The largest median deviations were detected in the y-axis of the mandible for both two groups, separately 1.36 mm in the experimental group and 1.19 mm in the control group. Apart from the maxillary yaw dimension (p = 0.005), there were no significant differences between the two groups in terms of linear and angular deviation. The experimental group had an overall treatment time of 18.05 ± 2.53 months, while the control group took 22.83 ± 3.60 months (p < 0.05). Therefore, the combined surgery-first and clear aligners treatment can achieve comparable skeletal stability to the conventional approach, while also saving significant time.
Comparison of the Effects of Anaesthesia Methods Used in Caesarean Delivery on Neonatal Cerebral and Renal Oxygenation: A Randomised Controlled Trial
Authors: Arslan Ulku , Kavrut Ozturk Nilgun , Kavakli Ali Sait , Dagdelen Hatice Ozge
Published: February 2024

Background: During a newborn’s adaptation to extrauterine life, many changes take place that are influenced by various factors. The type of delivery and anaesthesia strategy utilised during labour can modify these adaptive modifications. In this regard, this study was designed to compare the effects of general and spinal anaesthesia on cerebral and renal oxygenation after elective caesarean deliveries. Methods: This randomised controlled study comprised sixty parturient women who were over 18 years old and had a gestational age between 37 and 41 weeks. All participants had an ASA (American Society of Anesthesiologists) classification of II. Neonatal cerebral (CrSO2) and renal (RrSO2) regional oxygen saturations were assessed using near-infrared spectroscopy. Additionally, the 1st–5th min Apgar scores, preductal and postductal peripheral oxygen saturation (SpO2), and perfusion index were recorded in both the general anaesthesia and spinal anaesthesia groups. Results: There was no statistically significant difference between the two groups in terms of CrSO2 or RrSO2 values. The values of CrSO2 and RrSO2 in both groups showed a significant rise from the 10th to the 15th min, respectively. Conclusions: General and spinal anaesthesia techniques used for cesarean delivery have similar effects on neonatal cerebral and renal oxygenation.
Approach to Acute Myeloid Leukemia with Increased Eosinophils and Basophils
Authors: Papadakis Stavros , Liapis Ioannis , Papadhimitriou Stefanos I. , Spanoudakis Emmanouil , Kotsianidis Ioannis , Liapis Konstantinos
Published: February 2024

There is remarkable morphologic and genetic heterogeneity in acute myeloid leukemia (AML). In a small percentage of cases of AML, increased eosinophils and/or basophils are present in the bone marrow and sometimes in the peripheral blood. This is often a puzzling diagnostic situation but also an important finding that requires special investigation. Unique chromosomal rearrangements have been correlated with an increased number of eosinophils and basophils in AML. The identification of the underlying genetic lesion that promotes eosinophilia and basophilia can dramatically change both the prognosis and the treatment of the patient. Thus, clinicians must be vigilant in searching for the cause of eosinophilia and basophilia in patients with AML, since the different causes may lead to different treatments and survival outcomes. In this article, we examine the significance of increased eosinophils and/or basophils in the context of AML, provide guidance that simplifies the differential diagnosis, and give prognostic and therapeutic information about specific subtypes of AML associated with eosinophilia and/or basophilia. Evidence supporting personalized (molecularly targeted) therapy for these patients is also presented.
Predicting Long-Term Endothelial Cell Loss after Preloaded Descemet Membrane Endothelial Keratoplasty in Fuchs’ Endothelial Corneal Dystrophy: A Mathematical Model
Authors: Viola Pietro , Neri Enrico , Occhipinti Tommaso , Parekh Mohit , Cian Roberto , Ponzin Diego , Moramarco Antonio , Iovieno Alfonso
Published: February 2024

(1) Background: This study offers a biexponential model to estimate corneal endothelial cell decay (ECD) following preloaded “endothelium-in” Descemet membrane endothelial keratoplasty (DMEK) in Fuchs’ endothelial corneal dystrophy (FECD) patients; (2) Methods: A total of 65 eyes undergoing DMEK alone or combined with cataract surgery were evaluated. The follow-up period was divided into an early phase (first 6 months) and a late phase (up to 36 months). Endothelial cell count (ECC) and endothelial cell loss (ECL) were analyzed; (3) Results: The half time of the ECD was 3.03 months for the early phase and 131.50 months for the late phase. The predicted time-lapse interval to reach 500 cells/mm2 was 218 months (18.17 years), while the time-lapse interval to reach 250 cells/mm2 was 349 months (29.08 years). There was no statistically significant difference between the ECL in DMEK combined with cataract extraction and DMEK alone at 24 months (p ≥ 0.20). At the late phase, long-term ECL prediction revealed a lower ECC half time in patients undergoing DMEK combined with cataract surgery (98.05 months) than DMEK alone (250.32 months); (4) Conclusions: Based on the mathematical modeling, a predicted average half-life of a DMEK graft could reach 18 years in FECD. Moreover, combining cataract extraction with DMEK could result in excessive ECL in the long term.
Effect of Customized and Prefabricated Healing Abutments on Peri-Implant Soft Tissue and Bone in Immediate Implant Sites: A Randomized Controlled Trial
Authors: Chokaree Parima , Poovarodom Pongsakorn , Chaijareenont Pisaisit , Rungsiyakull Pimduen
Published: February 2024

This study aimed to evaluate the effect of customized healing abutments compared to prefabricated healing abutments in immediate implant sites. Twelve patients requiring single immediate implant placement were divided into two groups: a prefabricated group received prefabricated titanium healing abutments, and a customized group received a polyetheretherketone (PEEK) customized healing abutments fabricated based on the individuals’ digital impressions. Outcomes, including peri-implant horizontal and vertical soft tissue alteration, bone level change, volume change, pain score, and pink esthetic score (PES) change, were evaluated at the 1-, 4-, and 6-month follow-ups compared to pre-extraction teeth. At the 1- and 4-month follow-ups, the customized group had a significantly lower buccal volume variation (BVv). At the 6-month follow-up, neither group showed any significant difference in the marginal bone change; however, the customized group had a significantly lower PES change and a lower pain score. In the anterior and premolar regions, the customized group showed the preservation of peri-implant buccal horizontal soft tissue and buccal volume, while in the molar regions, the preservation of papilla height and midfacial height was observed. The morphology of the customized healing abutment demonstrated a better trend in preservation of peri-implant soft tissue, esthetic outcomes, and lower patient discomfort in immediate implant sites.