bluuebunny/crossref_metadata_2025 huggingface dataset:
A Novel Methodology for Automated Ransomware Detection via Deep Behavioral Sequence Mapping
Authors: Boyd Courtney , Johansson Stephen , McAllister Charles
Published: November 2024

Escalating ransomware attacks have emerged as a critical challenge for cybersecurity, with conventional detection techniques struggling to maintain effectiveness against increasingly sophisticated and evasive ransomware strains. Introducing a paradigm shift in detection methodology, Deep Behavioral Sequence Mapping (DBSM) leverages machine learning to analyze complex behavioral patterns rather than static indicators, offering an adaptive and robust framework for identifying ransomware. Unlike traditional approaches that rely on predefined signatures or rule sets, DBSM processes dynamic, sequential behaviors to detect ransomware even when obfuscation techniques are applied. Comprehensive evaluations demonstrate that DBSM achieves superior accuracy, precision, and recall, significantly reducing false positives while optimizing detection efficiency. Its scalability and low-latency processing enable real-time applications across enterprise-level environments, highlighting DBSM's potential as a critical component in automated threat defense systems. The study’s findings suggest DBSM’s capacity to enhance detection resilience and establish a new standard for ransomware threat mitigation within high-risk, large-scale infrastructures.
Quantum technologies for disease programs management
Authors: Revo Valeriy
Published: November 2024

The work showed that technologies managing the program content of diseases can already be available to medicine today. The purpose of the publication is to justify the need to study these programs as quantum-dimensional attributes of living things. The author used a classical systemic and a comparative approach. The main results of the work: 1) The quantum nature of chronic diseases is substantiated; 2) the main resources necessary for managing quantum-dimensional processes at the level of disease programs in the process of their initiation and development are presented; 3) the possibility of using quantum technologies to control the software content of diseases is substantiated. The practical significance of the work is to create the prerequisites for controlling quantum-dimensional processes in living organisms. This will dramatically increase the efficiency and reduce the cost of treatment and prevention of living organisms, including humans.
Determinants of Tax Avoidance in Indonesia: Moderating Role Political Connections
Authors: Aristiyaningrum Umi Laila , Falikhatun
Published: November 2024

This research aims to provide empirical evidence regarding thin capitalisation, transfer pricing, and tax avoidance, with political connections serving as moderating variables. The research employs a purposive sampling technique, resulting in a sample of 31 mining companies listed on the Indonesia Stock Exchange from 2013 to 2022. The technique used for hypothesis testing is panel data analysis through the Ordinary Least Squares (OLS) approach. The results of this research indicate that thin capitalisation and transfer pricing have a significant effect on tax avoidance. Additionally, this research reveals that the role of political connections can strengthen the impact of transfer pricing on tax avoidance but does not demonstrate that political connections can reinforce the effect of thin capitalisation on tax avoidance. The findings of this research are expected to serve as a basis for government considerations in establishing tax-related regulations. This study recommends that future research utilise different research subjects for comparison, add other independent variables outside the current model that may influence tax avoidance, and apply alternative tax avoidance measures, such as book-tax differences and tax shelters.
Prejudice Tied to State Centralization in Historical Societies
Authors: Dillion Danica , Liu Yuanze , Chen Yuqi , Watts Joseph , Zhao Cecilia , Baral Suryadyuti , Buckner William , Atari Mohammad , Kteily Nour , Jackson Joshua Conrad
Published: November 2024

Prejudice perpetuates social inequalities, shapes policies, and exacerbates conflicts. Despite its prevalence in modern human life, the origins of prejudice remain unclear. Using novel methods of historical text analysis, we test ecological and structural theories of how prejudice evolves. First, we code 389 ethnographic sources from 90 societies, finding that horizontal prejudice (group-based dislike) and vertical prejudice (superiority beliefs) are positively associated with state centralization but not with environmental threat, pathogens, or warfare. Second, we analyze ethnic prejudice in Chinese historical records (206 BCE–1911 CE) using a large language model, similarly showing that prejudice intensified during state centralization and diminished in periods of decentralized governance. These findings challenge the notion of prejudice as universal, and suggest instead that prejudice co-evolves with social structure.
Refugee agency in secondary mobility decision-making: a systematic literature review
Authors: Kavak Sinem , Hamza Mo , Gammeltoft-Hansen Thomas , Stone Russell A.
Published: November 2024

Decisions made by millions of refugees about where to go, how to make a living and how to secure a future are fundamental drivers of secondary movements. While a substantial body of literature addresses factors contributing to migrants’ decision-making, a comprehensive understanding of the central role of refugees in secondary mobility decision-making, including agency and strategies employed, remains underexplored. This is partly due to the belief that refugees are constrained by external and structural factors and cannot exercise agency, which we challenge. This article provides a systematic analysis of the literature on refugees’ secondary mobility decision-making processes. Using a systematic literature review (SLR) methodology, it presents an in-depth analysis of 40 peer?reviewed, English-language research articles selected from the Web of Science and Scopus databases published before September 2022. The article critically examines the drivers, prevailing dichotomies and conceptual frameworks surrounding refugee categorization, agency, and mobility. By synthesizing a wide range of literature, our paper presents emerging alternative concepts and frameworks that shed light on the complex dynamics of decision-making
Breakdowns at the border: legal infrastructures and political polarization
Authors: Ramji-Nogales Jaya
Published: November 2024

[abstract not applicable]
Propozycja unijnych ram prawnych dobrowolnej certyfikacji pochłaniania dwutlenku węgla – przyczynek do dyskusji
Authors: Bryk-Zwolska Małgorzata
Published: November 2024

Zdając sobie sprawę ze znaczenia, jakie ma usuwanie dwutlenku węgla dla realizacji globalnych i unijnych celów klimatycznych, Komisja Europejska we wniosku ogłoszonym 30 listopada 2022 r. zaproponowała ramy prawne certyfikacji dobrowolnego usuwania dwutlenku węgla (CDR). Starania Unii Europejskiej o stworzenie systemu certyfikacji CDR są ważną inicjatywą w tym zakresie, ale wiążą się z kluczowymi wyzwaniami, które powinny zostać pokonane w trakcie trwających procesów legislacyjnych. Cel opracowania stanowi ocena treści rzeczonego projektu rozporządzenia z punktu widzenia jego skuteczności jako narzędzia klimatycznego.
Tingimento natural em tecidos usando cascas dos frutos e serragem de madeira da Amazônia
Authors: Simões Pinto Sofia , Figueira Alves Letícia , Augusto Aguiar Ribeiro Gyovanni , Tunes Villani Fernanda
Published: November 2024

Considerando a crescente preocupação com a sustentabilidade na indústria têxtil, o tingimento natural representa uma alternativa viável e ambientalmente amigável aos corantes sintéticos. O objetivo foi avaliar a eficácia do tingimento natural na produção de cores vibrantes e duradouras, bem como seu impacto socioeconômico nas comunidades locais da Amazônia. A metodologia incluiu a coleta e preparação da matéria prima e tingimento nos tecidos de algodão e seda. O estudo investigou o processo de tingimento natural em tecidos utilizando  cascas dos frutos do tucumã e buriti e a serragem da madeira de andiroba, da região amazônica. Foram realizados testes de resistência à lavagem, desbotamento ao suor, salinidade e exposição solar para avaliar a durabilidade e qualidade dos tecidos tingidos. Os resultados demonstraram que os corantes naturais produziram cores vibrantes e duradouras nos tecidos, com resistência à lavagem e exposição solar. Além disso, o tingimento natural contribuiu para a geração de renda e valorização dos conhecimentos tradicionais das comunidades locais da Amazônia. Esses achados evidenciam o potencial do tingimento natural como uma alternativa sustentável e culturalmente significativa na indústria têxtil, promovendo a preservação ambiental e o desenvolvimento econômico das regiões produtoras.
Holistic Competencies of Chinese Preschool Teachers: Psychological, Physical, and Educational Dimensions
Authors: Qian Wang  , MohdNazri Abdul Rahman  , Amira Najiha Yahya  , Xinyue Zhang  , Nina Wang
Published: November 2024

Preschool teacher training and development addresses the multiplicity of domains and competence areas important in the general development of young children. The psychological, physical and pedagogical aspects of holistic capabilities of preschool teachers have been discussed in this study carried out in China. The research utilized the Partial Least Squares Structural Equation Modeling (PLS-SEM) as well as a quantitative approach in collecting information from 325 preschool teachers located in different regions. Consequently, it is clear that there are significant relationships among the competences: psychological competences like stress management and emotional intelligence have an acceptable influence on educational and physical competences as well. Teachers’ energy levels and physical health greatly affect their efficiency at teaching their pupils. These results emphasize the importance of an integrated approach to pedagogical development involving professional, emotional and psychical training for better instruction provision. This paper also underlines correlations between various capabilities, which is congruent with Gardner’s Theory of Multiple Intelligences and Bronfenbrenner’s Ecological Systems Theory. Some suggestions include creating inclusive teacher education programs; developing inspiring work settings; starting health initiative programs among others. Hence policy decision makers can understand that massive needs have to be met by facilitating holistic programmatic growths whilst rewarding continuous professional development in academics field. This study provides imperative insights into the diverse responsibilities of preschool teachers and lays the groundwork for future research probing longitudinal consequences and objective measures of teacher competence, despite its reliance on self-report data and a narrow geographic emphasis
Diagnóstico por imagem na medicina veterinária: avanços, aplicações e perspectivas futuras
Authors: Flores dos Santos Ana Carolyna , Rafaine Danielle
Published: November 2024

Imaging diagnostics in veterinary medicine have seen significant advancements over the years due to technological evolution, which has also pushed procedures and examinations in human medicine. The objective of this article is to discuss these advancements and future prospects in veterinary imaging, as well as to assess their impacts on the clinical routine of small animals. It is concluded that elastography and microbubble contrast are among the most promising available imaging methods, capable of aiding in more accurate and early diagnoses, as well as monitoring various treatments and procedures, thereby contributing to the advancement of the veterinary sciences.
Analisis Faktor-Faktor yang Memengaruhi Kepatuhan Pajak pada Mahasiswa Akuntansi di Pulau Jawa sebagai Potensial Wajib Pajak
Authors: Heriana Kamiliya Muthia Azra , Irawan Ferry
Published: November 2024

Penelitian ini bertujuan untuk menganalisis faktor-faktor yang memengaruhi kepatuhan pajak di kalangan mahasiswa akuntansi di Pulau Jawa sebagai calon wajib pajak. Penelitian menggunakan sampel sebanyak 162 responden yang dipilih melalui metode accidental sampling, dengan perhitungan sampel menggunakan rumus Lemeshow. Data dikumpulkan melalui kuesioner online dan dianalisis menggunakan metode Partial Least Square (PLS) dengan bantuan aplikasi SmartPLS. Hasil penelitian menunjukkan bahwa pengetahuan pajak, sanksi pajak (administratif dan pidana), tax morale, dan digitalisasi perpajakan memiliki dampak positif dan signifikan terhadap kepatuhan pajak pada mahasiswa akuntansi di Pulau Jawa sebagai calon wajib pajak. Untuk meningkatkan kepatuhan tersebut, diperlukan langkah-langkah strategis, seperti peningkatan program edukasi pajak, penerapan sanksi yang tegas dan adil, kampanye kesadaran pajak, serta pengembangan dan implementasi teknologi digital dalam sistem perpajakan.
Pengaruh Gaya Hidup, Literasi Keuangan, Mental Accounting dan Locus of Control Terhadap Pengelolaan Keuangan Gen-Z
Authors: Rismarina Raisha Adinda , Maulana Agus
Published: November 2024

Gen-Z merupakan demografi penduduk tertinggi di Indonesia saat ini. Pengelolaan keuangan Gen-Z akan berpengaruh kepada kondisi perekonomian indonesia. Sehingga penting bagi Gen-Z untuk melakukan pengelolaan keuangan yang baik. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh gaya hidup, literasi keuangan, mental accounting dan locus of control terhadap pengelolaan keuangan Gen-Z. Penelitian ini menggunakan pendekatan kuantitatif, dimana data diolah menggunakan metode SEM-PLS. Diperoleh 184 sampel berdasarkan karakteristik yang sudah ditentukan. Ditemukan bahwa gaya hidup serta literasi keuangan tidak memiliki pengaruh signifikan. Sementara mental accounting dan locus of control berpengaruh signifikan positif terhadap pengelolaan keuangan Gen-Z.
Perancangan Sistem Akuntansi Persediaan Pakan Ikan Berbasis Google Spreadsheet pada Usaha Budidaya Perikanan
Authors: Pantow Andreuw Kristian , Korompis Sintia Nurani , Rumambi Hedy Desiree , Rombot Raymond Festus , Paendong Yelly
Published: November 2024

This study aims to design a fish feed inventory record at UD Bless using Google Spreadsheets. The research method is qualitative. Primary data in this study were obtained by conducting direct interviews with business owners. Secondary data in this study are in the form of transaction evidence, inventory records arranged in archives. The results of the study are the design of a feed inventory accounting system at UD Bless which consists of a list of feed inventory, inventory purchases and sales, cash and credit inventory purchases, cash and credit inventory sales, and profitability of each type of inventory.
Desafíos socio-antropológicos de la Teoría de la Agenda Setting: reconstitución del modelo en un estudio de caso
Authors: Castillo Salina Yánder
Published: November 2024

Introducción: A pesar del éxito de la Teoría de la Agenda Setting se siguen reproduciendo debilidades de carácter socio-antropológico relacionadas con los paradigmas y tesis que la sustentan: alcance de los métodos positivistas, análisis desvinculados de la ideología y la cultura, mediocentrismo, fragmentación analítica, entre otros. Estas limitaciones no siempre posibilitan el estudio profundo de las agendas en contextos diferentes a los de desarrollo teórico tradicional (sociedad capitalista, urbana, democracia occidental…). Este artículo comunica la reflexividad sostenida para la reconstitución del modelo de agenda setting a fin de profundizar en las relaciones entre las agendas en un municipio cubano. Metodología: El nuevo marco teórico se construyó a partir del método dialéctico de construcción del conocimiento, combinando fases de revisión de estudios internacionales y del caso cubano, así como el trabajo empírico para validar las estrategias de profundización que se diseñaron. Resultados: Se fundamentó una perspectiva de “agendas interrelacionadas por procesos de comunicación de relevancia entre los campos sociales”, cuya comprensión abandonó el funcionalismo positivista para asentarse en el constructivismo-comunicacional. Discusión y Conclusiones: La implementación de este marco teórico durante 2019 en el municipio de Mella (Cuba) comprobó su pertinencia para sortear problemáticas profusamente criticadas a la Agenda Setting en el escenario internacional.
¿Es relevante la distinción entre verdad y posverdad?
Authors: Silva-García Karina
Published: November 2024

Introducción: Si bien el concepto de posverdad es relativamente reciente, este da cuenta de un fenómeno tan longevo como la política misma. La manipulación y la mentira siempre han estado presentes en los espacios políticos de interacción social, en este sentido la actualidad se distingue por el alcance y la velocidad con la que los discursos posverdaderos tienen lugar. Metodología: Desde el análisis crítico y reflexivo de diversos autores que han teorizado sobre el fenómeno de la posverdad, desde un enfoque filosófico discutimos al respecto de las dificultades que este fenómeno supone para el desarrollo de las democracias occidentales. Resultados: A partir de la revisión bibliográfica realizada, se observa cierta tendencia a, por una parte, reconocer el fenómeno de la posverdad como un fenómeno social y complejo. Por otra parte, considerar que la posverdad conduce al deterioro de las democracia en occidente.  Conclusiones: A partir de lo anterior concluimos que es necesario dinamitar el concepto de posverdad. El desarrollo y consolidación de democracias reales solo está dado por la posibilidad de que los ciudadanos sean capaces de ejercer su libertad y autonomía, atributos que han sido directamente socavados por la cultura de posverdad.
Validación de un modelo de enseñanza musical para la educación en general
Authors: Porflitt Becerra Felipe , Jeldres Zamorano Rolando Andrés , Norero Saavedra Alfonso
Published: November 2024

Introducción: El presente artículo revisa el estado del arte en base a la visión actual y antigua de la enseñanza de la música, mostrando concordancias y discordancias, con el objetivo de construir y validar un modelo de enseñanza de la música. Metodología: Se realizó una revisión de literatura para determinar las categorías de construcción y posterior diseño del modelo, el cual fue validado por docentes de distintos rangos etarios de la educación. Resultados: Se muestra una valoración alta al modelo en sí mismo, así como también, por el lado contrario, algunas discrepancias para docentes de enseñanza formal y no formal. Asimismo, existió una tensión entre si el uso de la teoría de la música es estrictamente necesaria en la educación, así como el orden jerárquico en interpretación musical respecto al ritmo, melodía y armonía, respectivamente. Discusión: Según lo relevado en este estudio, el modelo se valida para todo nivel educativo, y, además, los paradigmas antiguos y modernos pueden convivir en vez de ser excluyentes. Conclusiones: Un modelo para la enseñanza de la música en general en el siglo XXI debe tener la suficiente flexibilidad para que cada docente lo utilice confiando en su experticia.
Christine de Pizan y la “prudencia mundana” de las mujeres: un antecedente medieval para la construcción de un concepto de sostenibilidad filosófica
Authors: Ruiz Callejón Encarnación
Published: November 2024

Introducción: La filosofía medieval todavía se asocia a una mera transmisión de la filosofía griega centrada en la apología y justificación de la religión sin innovación conceptual o temática más allá del este ámbito. En este trabajo se analiza la posición disruptiva de Christine de Pizan. Metodología: A través de su crítica a las calumnias hacia las mujeres, se pone en crisis la ética, la desafección de la filosofía respecto a la mitad de la humanidad y la interpretación del saber heredado. Se analizan para ello las obras fundamentales de Pizan y dos de sus fuentes, Boecio y Salisbury. Resultados: La autora reivindica y dignifica la experiencia en primera persona como mujer y esta como fuente legítima de innovación y conocimiento. Discusión: Se analiza el origen de las afirmaciones que difaman a las mujeres y el origen no racional de las mismas. Se propone aplicar el concepto emersoniano de hombre representativo a la autora e introducir la noción de sostenibilidad en la metodología filosófica de la historia de la filosofía señalando la figura de Christine como antecedente medieval. Conclusiones: Christine de Pizan visibiliza una injusticia y una tiranía olvidadas. Ofrece estrategias hermenéuticas distintas a las del saber erudito y pone en valor su propia experiencia en este caso como sujeto vulnerable
Las quebradas y su potencial en la habitabilidad urbana. Mirada desde la consulta ciudadana de Loja-Ecuador
Authors: Moncayo Vega Alexandra
Published: November 2024

Introducción: La ONU-Hábitat recomienda la creación de espacios públicos urbanos que sean seguros, confortables, inclusivos y verdes. En este contexto, surge la necesidad de considerar los bordes de ríos y quebradas como parte de estos espacios públicos, dado que presentan realidades complejas en términos de habitabilidad. El objetivo de este estudio es analizar la percepción de un segmento de la ciudadanía lojana respecto a los bordes de quebradas urbanas, considerados como "oblitopías" o espacios olvidados. Metodología: Se utilizó una metodología mixta, con enfoques cualitativo y cuantitativo, de carácter no experimental, empleando métodos analítico, sintético y descriptivo. A través de una encuesta estructurada en línea, administrada mediante la herramienta KoBoToolbox, se recolectaron respuestas de una muestra intencionada de 283 adultos jóvenes (entre 18 y 25 años). De las 26 preguntas formuladas, se seleccionaron 16 para abordar los aspectos de habitabilidad, agrupados en dimensiones físico-espaciales, medioambientales y psico-espaciales, con el fin de obtener una percepción integral de los encuestados. Resultados: Los resultados revelan que los encuestados identifican claramente tanto los problemas como el potencial de las quebradas. Reconocen el valor paisajístico de estos espacios y expresan un interés significativo en participar en su recuperación como espacios públicos habitables. Discusión: La percepción ciudadana subraya la necesidad de revalorizar los bordes de quebradas urbanas, reconociendo su potencial como espacios verdes que pueden contribuir al bienestar urbano. Sin embargo, la recuperación de estos espacios enfrenta desafíos debido a su estatus como "oblitopías" y la falta de intervención efectiva en su acondicionamiento como áreas habitables. Conclusiones: El estudio concluye que existe una disposición entre los jóvenes lojanos para colaborar en la recuperación de las quebradas urbanas como espacios públicos habitables. Se recomienda que los esfuerzos de rehabilitación y desarrollo de estos bordes se integren en la planificación urbana, promoviendo una habitabilidad inclusiva y sostenible que transforme estas áreas en lugares de esparcimiento y conexión con la naturaleza.
Педагогічний транслінгвізм: на прикладі початкової школи Баварії
Authors: Палій О. А. , Демченко Н. М. , Шпекбахер Т. О.
Published: November 2024

Статтю присвячено проблемі реалізації педагогічного транслінгвізма в освітньому процесі початкової школи в Німеччині. У статті розглянуто проблеми школи в країнах мігрантів, таких як Німеччина, які характеризуються як місця, де поєднуються різні культури та мови. З’ясовано, що мовна гетерогенність у початкових школах також постійно зростає і стає ще більшою через війну в Україні. Тому одномовна культура в сьогоднішніх школах повинна бути ретельно вивчена. Зроблено акцент на актуальності питання про концепції, які сприяють інтеграції дітей мігрантського походження та визнають багатомовність учнів як навчальний ресурс. Проаналізовано підхід педагогічної транлінгвістики для підтримки українських дітей та сприяння багатомовності серед усіх учнів. Проведено аналіз результатів численних досліджень в англомовних і німецькомовних країнах, на основі якого зроблено позитивні висновки щодо інклюзії в школі та соціально-емоційного розвитку учнів. Подано методи створення багатомовного та мультикультурного навчального середовища, а також організації уроків з вивченням мови з урахуванням Баварської навчальної програми PLUS. Зроблено висновок щодо доцільності використання спеціальних роздаткових матеріалів. На основі методичної роботи в галузі транслінгвістики розроблено посібник, який слід розглядати як джерело натхнення для роботи з українськими дітьми. Водночас зазначено, що це слід розглядати як інструмент сприяння багатомовності для всіх дітей і використання мовної неоднорідності як можливості організації спільного навчання. Керуючись ідеєю, що кожна людина має унікальний, індивідуальний мовний репертуар, який складається з різних мовних переживань, а навчальний переклад ставить за мету розпізнавати всі мови учнів, поставити під сумнів мовні ієрархії та сприяти багатомовності для всіх дітей, зроблено виновок, що початкові школи мають недостатні ресурси, такі як викладачі чи перекладачі, які розмовляють рідною мовою. Велика кількість початкових шкіл у Баварії навіть не мають концепції щодо різних мовних потреб учнів.
Malignant transformation of vestibular schwannoma 29 years after Gamma Knife radiosurgery: illustrative case
Authors: Ishikawa Takayuki , Nagatani Tetsuya
Published: November 2024

BACKGROUND

Vestibular schwannomas are common posterior fossa tumors, often managed with stereotactic radiosurgery (SRS) due to its low invasiveness and high tumor control rates. However, malignant transformation of vestibular schwannoma (MTVS) is a rare but serious complication with a poor prognosis.

OBSERVATIONS

The authors present a case of MTVS occurring 29 years after initial SRS, the longest latency reported. A 68-year-old woman developed sudden facial nerve paralysis, with magnetic resonance imaging revealing tumor regrowth. Surgical removal and histopathological analysis confirmed malignant transformation, characterized by spindle-shaped atypical cells and significant p53 positivity. Despite multiple surgeries and radiation therapy, the tumor exhibited rapid regrowth and cerebrospinal dissemination, leading to a poor prognosis.

LESSONS

This case underscores the critical importance of long-term monitoring after SRS, as malignant transformation can occur decades later. Additionally, it highlights the potential necessity for early intervention during malignant transformation to improve patient outcomes, despite the challenges in identifying effective treatments for MTVS.

https://thejns.org/doi/10.3171/CASE24526
Clazosentan-induced reversible focal brain edema in basal ganglia following aneurysmal subarachnoid hemorrhage treatment: illustrative case
Authors: Oishi Hiroyuki , Kato Takenori , Hasegawa Toshinori , Naito Takehiro , Mizuno Akihiro , Kageyama Akinori , Sakai Yosuke
Published: November 2024

BACKGROUND

Clazosentan, a selective endothelin A receptor antagonist, effectively prevents cerebral vasospasm following aneurysmal subarachnoid hemorrhage. Although various adverse effects have been reported, there have been no specific case reports of clazosentan-associated focal brain edema. This report highlights a rare complication associated with clazosentan treatment.

OBSERVATIONS

A female in her 70s with a subarachnoid hemorrhage underwent surgical clipping of a ruptured middle cerebral artery aneurysm and received clazosentan postoperatively. Six days after surgery, magnetic resonance imaging revealed high-intensity signals in the left basal ganglia on fluid-attenuated inversion recovery and apparent diffusion coefficient sequences without changes on diffusion-weighted imaging. The patient’s right-sided hemiparesis and disturbance of consciousness gradually progressed. On day 9, clazosentan was discontinued because of suspected adverse effects. Within approximately 2 weeks of discontinuation, both imaging findings and neurological symptoms improved. The temporal relationship between clazosentan administration, symptom onset, and improvement after discontinuation strongly suggested clazosentan-induced vasogenic edema.

LESSONS

Clazosentan can cause reversible localized vasogenic brain edema in the basal ganglia following subarachnoid hemorrhage treatment. This rare but significant complication underscores the importance of careful neurological monitoring and timely imaging in patients receiving clazosentan. Further research is required to understand the risk factors and mechanisms underlying this phenomenon.

https://thejns.org/doi/10.3171/CASE24567
Turizm ve yerel yönetim konulu akademik yayınların bibliyometrik analizi
Authors: Kara Emrah , Dalgın Taner , Çeken Hüseyin , Güner Bilgin
Published: November 2024

Turizm sektörünün gelişimine yön veren birçok paydaş bulunmaktadır. Bu paydaşlardan biri hatta en önemlisi de yerel yönetimlerdir. Bu bağlamda bu çalışmanın amacı, turizm ve yerel yönetim konularının birlikte yer aldığı akademik çalışmaları bibliyometrik analiz yöntemi ile inceleyerek mevcut durumu ve güncel eğilimleri belirlemektir. Bu kapsamda 23 Ağustos 2023 tarihinde Web of Science veri tabanında yıl sınırlaması yapılmadan “tourism” and “local government*” anahtar kelimelerinin birlikte geçtiği akademik çalışmalar taranmıştır. Doküman türü ve dil konusunda filtreleme yapıldıktan sonra 1994 ile 2023 yılları arasında 870 çalışma değerlendirmeye dahil edilmiştir. Elde edilen veriler VOSviewer programı ile analiz edilmiştir. Bulgulara göre; turizm ve yerel yönetim ilişkisini inceleyen akademik çalışmaların sayısında giderek artış eğilimi olduğu, en çok çalışmanın 2021 yılında yapıldığı ve bu konudaki en çok atıfın ise 2022 yılında verildiği tespit edilmiştir. Turizm ve yerel yönetim konusunda yapılan çalışmalar en çok “Konaklama Boş Zaman Spor Turizm” alanında yayımlanırken, en fazla yayın yapılan kaynak “Sustainability” dergisi olmuştur. Turizm ve yerel yönetim konusuna yönelik en çok kullanılan anahtar kelimenin “turizm” olduğu saptanmıştır. En çok iş birliği yapan yazar “Xu, Honggang” dır. En fazla iş birliği yapan ülke ise “Çin” olmuştur. “Doğan Gürsoy” en çok atıf alan yazar olarak ön plana çıkmaktadır. “Tourism Management” dergisinin en fazla atıf alan kaynak olduğu ortaya çıkmıştır. Bu çalışma turizm ve yerel yönetim konusuna odaklanan ilk bibliyometrik analiz olup, literatüre katkı sağlayacağı düşünülmektedir.
Destinasyon unsurları açısından Bandırma ve yeni bir tur rotası önerisi
Authors: Şahin Seda , Ünver Murat
Published: November 2024

Bir bölgenin turizme kazandırılması için çekicilik, ulaşılabilirlik, olanaklar, hazır paketler, aktiviteler ve yardımcı hizmetler gibi birtakım kriterlere sahip olması gerekir. Bandırma sahip olduğu tarihi, doğal ve kültürel değerlerinin yanı sıra; konumu ve ulaşım imkanları ile de turizmde yoğun talep gören bir destinasyon olabilecek kriterlere sahiptir. Ancak ziyaretçi sayıları incelendiğinde Bandırma’nın turizmde hak ettiği payı alamadığı görülmektedir. Bu doğrultuda Bandırma, sahip olduğu turistik arz kaynakları açısından incelenmiş, mevcut ve potansiyel turizm olanakları değerlendirilmiştir. Bir destinasyonun sahip olması gereken unsurlar Bandırma özelinde değerlendirildiğinde en önemli eksiğin hazır paketler bir başka ifadeyle Bandırma’yı kapsayan paket turun neredeyse hiç olmadığı ortaya çıkmıştır. Bu noktada, Bandırma’nın tanıtımına ve sahip olduğu potansiyeline katkısı olacağı fikrinden hareketle yarım günlük, günübirlik ve bir gece konaklamalı olmak üzere iki günlük alternatif tur rotaları önerilmiştir. Sonuç olarak, her yıl milyonlarca ziyaretçinin farklı destinasyonlara giderken Bandırma’dan sadece transit olarak geçmesi sebebiyle, sahip olduğu eşsiz tarihi ve kültürel birikiminin turizm açısından yeterince değerlendirilemiyor oluşu değerlendirilmiş ve düzenlenen tur rotası önerileri ile bölgenin aktif olarak turizmin içine nasıl çekileceği gibi sorulara yanıtlar verilmiştir. Ayrıca bu çalışmanın Bandırma’nın destinasyon açısından en önemli eksiği olan hazır paketler sorununa bir çözüm önermesi ve Bandırma özelinde bu konuyla ilgili sınırlı sayıda çalışmalara rastlanılması nedeniyle önemli olduğu düşünülmektedir. Çalışma sonucunda ortaya konulan bulgu ve önerilerin daha sonraki araştırmalara ve bir bölgeyi tanıtmada öneli rol üstlenen turist rehberlerine de yol gösterici olacağı düşünülmektedir.
XVI. yüzyıldan XIX. yüzyıla Kepsud Nahiyesi Vakıfları
Authors: Sarı Serkan
Published: November 2024

Türk-İslam medeniyetinin kimliğini oluşturan müesseselerden birisi olarak vakıf müessesesi ve işleyişi Osmanlı toplum yapısının şekillenmesinde önem arz etmektedir. İslam kültürünün geliştirdiği yardımlaşma ve dayanışma duygusunun, sistemli ve devamlılık arz eder bir şekilde müesseseleştirilerek uzun yıllarca İslam toplumunun ihtiyaçları bu müesseseler tarafından karşılanmıştır. İslam tarihi içerisinde vakıf müessesesinin en işlevli ve sistemli olarak geliştirildiği dönem Osmanlı Dönemi olmuştur demek mümkündür. Osmanlı devlet yapısı içerisinde vakıf müessesesinin işleyişi ve devamlılığı özellikle dikkat edilen ve özen gösterilen bir husus olarak dikkati çekmektedir. Vakıfların oluşturulması, sınırlandırılması, hangi şartlarla işleyeceği, faydalanacak hedef kitle ve vakfın nasıl idare olunacağı kayıt altına alınarak hem işleyişle ilgili problemlerin önüne geçilmiş hem de uzun soluklu olmaları sağlanmıştır. Çalışma, Osmanlının klasik döneminden XIX. Yüzyıla kadar Kepsud Nahiyesinde bulunan vakıflarla ilgili olacaktır. Çalışmanın temelini Osmanlı arşiv kaynakları oluşturacaktır. Kayıtlar incelendiğinde bahsedilen zaman aralığı temel alınmış olmakla birlikte, kayıtlarda daha önceki dönemlerin izleri de görülecektir. Arşiv belgeleri tetkik edildiğinde Kepsud Nahiyesinde ulaşılan vakıflar, Medine-i Münevvere vakıfları, selatin vakıfları ve amme vakıfları olarak gruplandırılmış ve bahsedilen vakıflarla ilgili tahliller yapılmıştır. Çalışmanın temel kaynakları olarak Osmanlı arşiv kaynakları temel alınmış ve bahsedilen belgelerde Kepsut Nahiyesi vakıfları ile ilgili bilgiler ortaya çıkartılarak tetkik ve tahlil edilmiştir. Bahsedilen vakıflarla ilgili belgelerde bulunan bilgilerden hareketle Osmanlı dönemi Kepsud Nahiyesinin toplumsal yapısı, iktisadi ve idari yapısı ile alakalı yorumlamalara gitmek mümkün olacaktır.
Yerel politikalara katılımın artırılmasında kent konseylerinin etkinliği ve önemi: Balıkesir kent konseyi örneği
Authors: Uçar Ahmet
Published: November 2024

Yerel politikalar daha çok belediyelerde başkan ve meclis gibi karar organlarının aldığı kararlar sonucu oluşturulan politikalardır. Bu politikalar haliyle sadece o belde halk ı için gerçekleştirilecek hizmet ve faaliyetleri kapsamaktadır. Bu açıdan yerel politikaların oluşumunda halkın ihtiyacına yönelik hizmet ve faaliyetleri belirlemede halkın görüşlerinin alınması ve halkın politikalara katılımı önemlidir. Yerel politikaların oluşturulması ve bu politikalara katılım demokrasinin uygulanmasına en fazla olanak sağlayan uygulamalar olduğu söylenebilir. Zira yerel politikalar halkın yaşadıkları kentte o kentin seçilmiş yöneticileri tarafından oluşturulduğu için halkın en kolay ve hızlı katılabildiği politikalardır. Belediye yönetim sistemimize 2005 yılında çıkarılmış olan 5393 sayılı Belediye Kanunu ile girmiş olan kent konseyleri yerel politikalara katılımı sağlamak ve artırmak için oluşturulan bir uygulamadır. Demokrasinin uygulanabilirliğini ve katılımcılığı sağlamak için 2005 yılından bu yana bir kısım belediyeler kent konseylerini kurmuş ve yerel politikalarını oluştururken zaman zaman kent konseylerinin görüşlerini de dikkate almışlardır.
Bu çalışmada, önce literatürde kent konseylerinin katılımcılığa olan etkisi üzerine yapılmış çalışmalar incelenerek kent konseylerinin faaliyetleri araştırılıp yerel politikalarda katılımcılığa olan katkıları ortaya çıkarılmaya çalışılmıştır. Sonrasında Balıkesir Kent Konseyinin faaliyetleri incelenerek katılımcılık açısından yaptıkları katkılar belirlenmeye çalışılmıştır. Ancak incelenen faaliyetlerden çıkan sonuçlara göre konseyin Balıkesir Büyükşehir Belediyesinin meclis kararlarında çok az etkisi olduğu sonucuna varılmış olup sonuç bölümünde kent konseylerinin katılımcılığı artırabilmesi için bazı öneriler geliştirilmiştir.
Analysis of Metaverses Structure and Characteristics
Authors: Gorbacheva Lyubov , Volkov Artem
Published: November 2024

Statement of the problem: The fundamental changes currently taking place in the development of networks and communication systems are concentrated in the concept of creating metaverses. Despite the fact that this concept appeared within the framework of the International Telecommunication Union only in 2023, research in this area already occupies the first line in scientific publications on networks and communication systems. In the Russian Federation, this area of investigation is currently not given the required attention. The goal of the paper is to analyze the documents of the Telecommunication Standardization Sector of the International Telecommunication Union (ITU-T) and determine the structure and characteristics of metaverses based on the results of the ITU-T focus group on metaverses. The method used is systems analysis. Result: definition, structure, including virtual and mirror worlds, characteristics of metaverses. Novelty: The conducted analysis allowed us to define the concept of the metaverse and its constituent worlds: virtual world and mirror world, as well as an important feature of metaverses such as logging, which is a log of the life of users and objects. These results allow us to accurately determine the vector of further research. Theoretical/Practical significance: a fundamental definition of metaverses, their structure and characteristics are obtained. From a practical point of view, the results obtained make it possible to begin a set of scientific investigations on metaverses on conceptual and systemic basis that meets international standards.
Crisis of loyalty and the defense of Empire in the estimates of the british Military class: colonial army during the inter-war period
Authors: Malkin Stanislav G.
Published: November 2024

In the interwar period, three powerful ideological factors – nationalism, pan-Islamism, and communism - simultaneously undermined the power of the metropolis in the dependent territories. Behind this façade, as was reasonably assumed in Delhi, Simla, Jerusalem, Cairo, and London, the interests of rival states were concealed. Overseas territories were seen both as a source of strength (economy, international prestige) and weakness (diversion of resources because of the leadership’s belief in the existence of an external threat).The historiography of the British Empire pays attention to how the colonial administrations and the metropolis responded to the challenges posed by the prospects of combining crises of loyalty and worsening international competition into a single problem of ensuring colonial order after the First World War. The question remains open about how the representatives of the military class themselves looked at such a cross-border threat. The article shows that, in this light, one of the key topics for the army corporation in the framework of the professional discussion was the institutionalization of the colonial army. To what extent did the esprit de corps of the British Army have an imperil character in terms of institutional peculiarities and public self-presentation? Was colonial service has been perceived as a priority over participation in conventional conflict in the training of the officer corps? How was it supposed to solve the problem of the growing obligations of the army to suppress anti-colonial protests (including guerrilla warfare in full-scale) against the background of worsening international relations, financial shortages and personnel restrictions? To what extend did the logics of the military thought development and corporate interests had mirrored the evolution of the colonial rule’ models after the Great War? As the results of the presented study demonstrates, these issues did not only constellate internal and interdepartmental discussions on the declared topic. Their participants had a hand in the further development of a wider discursive field – about the prospects for the future of the British Empire as such.
Биосинтез рекомбинантных вакцин в растительных системах экспрессии
Authors: Уварова Е. А. , Белавин П. А. , Пермякова Н. В. , Дейнеко Е. В.
Published: November 2024

Успехи генной инженерии способствовали возникновению нового раздела вакцинологии – создание рекомбинантных субъединичных вакцин, инициирующих формирование защитного иммунитета от различных заболеваний. Одной из перспективных и активно развивающихся систем экспрессии рекомбинантных белков медицинского назначения являются растения. В данном обзоре в общих чертах освещается формирование специфического и неспецифического иммунитета, функционирование гуморального и клеточного звеньев иммунитета, а также принципы создания рекомбинантных вакцинных препаратов. Более подробно рассматривается создание вакцинных препаратов для профилактики таких инфекций как грипп, коронавирусы, вирус папилломы человека, вирус гепатита В и норовирусы с примерами растительных рекомбинантных белков, профилактирующих эти заболевания. Дана оценка рынка рекомбинантных вакцин растительного происхождения и приведены примеры наиболее успешных из них. В целом обзор призван подчеркнуть актуальность растительных систем экспрессии для наработки рекомбинантных вакцинных препаратов и их возможности для быстрого реагирования на возникающие вызовы в области профилактики инфекционных заболеваний.
Генетическая инженерия как методологическая основа функциональной геномики растений
Authors: Фадеев В. С.
Published: November 2024

Функциональная геномика изучает динамические аспекты экспрессии генов и геномов, тонкие механизмы транскрипции и трансляции, а также межбелковые взаимодействия компонентов, участников этих процессов. Генетическая инженерия включает в себя комплекс знаний и разработанных методик, позволяющих экспериментально исследовать физиологическую роль генных продуктов, что является одной из задач функциональной геномики. Комплексные исследования, связанные с изучением функционирования генома, требуют анализа большого объема данных. В данном случае используют алгоритмы биоинформатики – междисциплинарной области, объединяющей комплекс наук и компьютерных технологий. В настоящем обзоре рассмотрены комбинированные методологические приемы, используемые в современной генной инженерии по изучению физиологической роли генов на моделях стабильных трансформантов растений. Наибольшее внимание уделено инсерционному мутагенезу и РНК-интерференции, а также их применению в свете изучения тонких механизмов ключевых биологических процессов.
Влияние rol-Генов Agrobacterium rhizogenes штаммов А4, 15834 и K599 на рост корней трансгенных растений табака и состояние антиоксидантной системы в условиях абиотического стресса
Authors: Швец Д. Ю. , Бережнева З. А. , Мусин Х. Г. , Кулуев Б. Р.
Published: November 2024

Генетическая трансформация rol-генами Agrobacterium rhizogenes приводит к многочисленным фенотипическим изменениям, в том числе к повышению стрессоустойчивости трансгенных растений. Механизмы стрессоустойчивости у растений, экспрессирующих rol-гены, остаются малоизученными, кроме того, фенотипические эффекты этих трансгенов зависят от того, из какого штамма агробактерий они происходят. Целью работы было создание трансгенных растений табака Nicotiana tabacum L., несущих rol-гены штаммов A4, 15834 и K599 A. rhizogenes, анализ их стрессоустойчивости и состояния антиоксидантной системы. Трансгенные растения с rol-генами штаммов A4 и 15834 характеризовались увеличением скорости роста корней, как при нормальных условиях, так и при воздействии повышенных концентраций хлорида натрия и ацетата кадмия по сравнению с диким типом. Экспрессия rol-генов штамма К599 оказывала негативное действие на рост корней трансгенных растений табака как в норме, так и в стрессовых условиях засоления, гипотермии и повышенных концентрациях ацетата кадмия. В корнях трансгенных растений табака в оптимальных условиях и при засолении экспрессия rol-генов штаммов A4 и 15834 способствовала повышению количества общего растворимого белка, пролина, общего пула глутатиона и активности супероксиддисмутазы. В корнях трансгенных растений с rol-генами штамма К599 в условиях засоления обнаруживалось повышение активности супероксиддисмутазы, гваяколпероксидазы и глутатион-S-трансферазы. Таким образом, показано, что положительный эффект экспрессии rol-генов на рост корней трансгенных растений может быть связан с влиянием на различные компоненты антиоксидантной системы. Полученные нами результаты говорят о перспективности использования rol-генов штаммов А4 и 15834 A. rhizogenes для создания новых сортов и линий растений с улучшенными параметрами роста корней и повышенной стрессоустойчивостью, тогда как rol-гены штамма К599 не подходят для таких целей.
Influence of rope fastening on the spectrum of its natural transverse vibrations
Authors: Muratov Kamil , Likhachev Danil , Sokolov Roman , Chekhunova Anna , Osintseva Marina , Vaganov Alexei
Published: November 2024

According to the previously developed method, which takes into account the bending stiffness of steel ropes during their transverse oscillation, the ropes of the pedestrian bridge ‘Lovers’ in the city of Tyumen were investigated. The obtained values of tension forces and bending stiffness were within the expected range. The high variation of bending stiffness values forced to pay attention to the accuracy of the initial values of rope lengths, which were obtained from the photograph. To measure the rope lengths, a method of nodal harmonic registration was proposed, but the results obtained by this method were higher than the values obtained from the photograph. The evaluation of measurement errors did not explain this overestimation, which led to the necessity to revise the solution of the differential equation of transverse oscillations. It turned out that previously only its partial solution was considered, assuming a hinged rope attachment, whereas it is cantilevered and has a bending reaction. Taking this feature into account by introducing an additional boundary condition allowed to improve the calculation model and explain the overestimation of the rope length in the method of nodal harmonics.Taking into account the nature of the rope attachment allowed us to introduce a generalised parameter s, which takes zero value for rigid cantilever attachment, and is equal to one for articulated attachment. Then the stiffness weakening inside the anchorage will be manifested by the growth of the parameter s and can be detected by the results of the oscillation spectrum registration.
Media narratives in the social history of medicine: the case study of the 1949 Khabarovsk trial
Authors: Nagornykh O. S. , Shok N. P.
Published: November 2024

In the article, the authors explore media narratives of the tribunal held inDecember 1949 inKhabarovsk overJapanese doctors recognized as war criminals involved in the development and use of bacteriological weapons, as well as conducting medical experiments on humans that are incompatible with the norms of morality and ethics of medicine.The purpose of the article is to explore theKhabarovsk process in the broad context of the social history of science using domestic archival materials, published memoirs of eyewitnesses and participants in the process, as well as periodic publications (mainly regional) as the main historical sources.Acomprehensive study of this plot made it possible, through the analysis of media narratives, to supplement historiography with materials from theFarEastern region, which allowed us to select not only the historical context, but also to restore little-studied aspects of informingSoviet society about theKhabarovsk process, to identify international resonance for this event.