bluuebunny/crossref_metadata_2025 huggingface dataset:
Rancang Bangun Sistem Smart Street Light Menggunakan Arduino Berbasis Internet of Things
Authors: Hidayat Robi Taofik , Nugroho Irvan Aditya , Saputra Duta Manuarva Wahyu , Marzuki Marza Ihsan
Published: August 2023

Listrik sangat penting dalam kehidupan sehari-hari dan kebutuhannya terus meningkat setiap tahun. Salah satu penggunaannya adalah penerangan lampu jalan. Namun, pada jam-jam tertentu seperti dini hari, lalu lintas kendaraan sedikit, menyebabkan pemborosan energi listrik yang cukup besar jika lampu menyala sepanjang malam. Selama ini penggunaan listrik konvensional dari energi fosil akan berdampak negatif pada lingkungan akibat emisi karbon. Untuk mengatasi masalah ini, kami merancang sistem smart street light menggunakan Arduino berbasis Internet of Things (IoT). Rancangan ini menggunakan metode eksperimental untuk membuat prototipe smart city light berbasis IoT. Prinsip kerjanya adalah lampu akan menyala secara otomatis saat ada kendaraan yang melewati, sehingga menghemat energi. Selain itu, solar panel digunakan sebagai sumber energi yang ramah lingkungan. Sedangkan sistem IoT digunakan untuk memantau daya yang tersimpan pada baterai.
EFL Learners’ Comprehension of Extensive Reading Based on Higher Order Thinking Skills.
Authors: Pramaysella Trisha Fitri , Thamrin Nani Ronsani , Darsih Endang
Published: August 2023

This study, conducted at a private university in Kuningan, West Java, aimed to understand the comprehension of learners based on Higher Order Thinking Skills (HOTS) in Extensive Reading classes as well as to identify the reasons why some students find it challenging to understand reading based on HOTS in these classes. The three steps of the HOTS definition by Anderson and Krathwohl (2001) were analysis (C4), evaluation (C5), and creation (C6). The research is descriptive-qualitative, and the methods for gathering data include interviewing and observation. Second-semester students at a private university in Kuningan, West Java, served as the study's subjects. The observation's findings showed that the majority of second-semester students were capable of analyzing the information (Analyzing, C4), evaluating the text's main ideas (Evaluating, C5), and coming up with new ideas to use in other situations (Creating, C6), whether outside of the classroom or on other occasions. Moreover, based on the results of interviews with 10 students in the classroom, there were 5 main factors that affect the students’ reading comprehension based on HOTS which were: lack of vocabulary, lack of focus, lack of time, not having basic knowledge and not interesting in reading.
IMPROVING THE STUDENTS’ ENGLISH VOCABULARY BY USING PICTURES AT SDN MOJOLANGU 04
Authors: Sari Rafika , Mukarom Mukarom
Published: August 2023

Learning English as a foreign language is part of formal education that has been applied educational units. Vocabulary is a basis for understanding a reading content that containts meaning. The subjects of this study were fifth grade students of SDN Mojolangu 04. The procedure of this study used two cycles, namely cycle I and cycle II, each cycle consisted of 4 stages; planning, action, observation, and reflection. In the results of this study, there was an effective increase in the level of vocabulary mastery of fifth grade students at SDN Mojolangu 04. After implementing pictures with words in cycle I, the classical success score was 52% increased to cycle II 85% while before applying picture media to the activity pre-test score only reached 9%. Thus, in this activity the students gave positive responses such as listening to explanations with focus and following instructions. Memorize and understand the meaning of English vocabulary.  Even in the learning process, the students were more active in cycle II than cycle I. Of course, applying picture media could increase students' English vocabulary.
MANTRA TOLAK BALA SEBAGAI SASTRA LISAN DALAM UPACARA ADAT TEPUNG TAWAR MASYARAKAT MELAYU SAMBAS KALIMANTAN BARAT (Kajian Perspektif Antropologi Sastra)
Authors: - Melin - , Ahmad Harun , Setyowati Endang
Published: August 2023

Upacara adat Tepung Tawar masyarakat Melayu Sambas Kalimantan Barat menyuguhkan suatu fenomena penggunaan mantra Tolak Bala sebagai sastra lisan dilihat dari sisi bentuk, fungsi, hakikat, dan pandangan masyarakat yang sangat menarik jika dikaji dalam perspektif antropologi sastra. Penelitin ini bertujuan untuk mengetahui dan mendeskripsikan bentuk, fungsi, hakikat dan pandangan masyarakat terhadap mantra Tolak Bala sebagai sastra lisan yang terdapat di dalam upacara adat tersebut. Pendekatan yang digunakan adalah pendekatan penelitian kualitatif dengan metode analisis antropologi sastra. Langkah yang ditempuh dalam melakukan analisis terhadap bentuk, fungsi, hakikat, dan pandangan masyarakat tentang mantra Tolak Bala sebagai sastra lisan adalah mengidentifikasi untuk menemukenali yang selanjutnya dianalisis dan disimpulkan. Untuk memperkuat temuan tentang eksistensi mantra tersebut dilakukan wawancara tidak terstruktur. Mantra Tolak Bala adalah mantra yang berbentuk permohonan yang digunakan dalam proses pelaksanaan upacara adat Tepung Tawar masyarakat Melayu Sambas dengan menggunakan air sebagai medianya. Mantra Tolak Bala berfungsi sebagai (1) penolak bala dan kesialan, (2) mengobati penyakit, dan (3) meminta keselamatan. Hakikat mantra Tolak Bala adalah untuk memohon keselamatan dari bala dan kesialan, yang terdiri atas dua jenis yaitu mantra baru dan mantra lama. Mantra yang digunakan dalam upacara Tepung Tawar adalah mantra baru, karena mantra lama tidak bisa digunakan lagi dengan alasan tertentu. Tidak semua pandangan masyarakat terhadap mantra Tolak Bala sama, tergantung pemahaman masyarakat berdasarkan usia dan pengalaman hidup rmasyarakat.
Ritual Saiso Terhadap Padi Yang Dipanen (Saiso napare a muttuna pamakeni) Kebudayaan Sumba Barat Daya Dalam Kajian etnoliguistik Kajian
Authors: Ege Maria Susana , Nugrahani Ari
Published: August 2023

ABSTRAKRitual merupakan suatu upacara atau tindakan yang diselenggarakan atau dilakukan oleh masyarakat yang berkaitan dengan kepercayaan atau keyakinan lokal berdasarkan hukum adat yang berlaku dan disepakati bersama oleh masyarakat tertentu. Adapun permasalahan dalam penellitIan ini yaitu; 1) Bagaimana Masyarakat Desa delo mempergunakan padi sebagai simbol atau perantara kepercayaan Marapu dalam kebudayaan Ritual Saiso, di Desa Delo, Kecamatan Wewewa Selatan, Kabupaten Sumba Barat Daya. 2)Bagaimana cara mempertahankan penggunaan bahasa dalam kebudayaan Ritual Saiso. Metode penelitian ini adalah pendekatan kualitatif dengan metode deskriptif menggunakan teknik pengumpulan data, observasi,wawancara, dan dokumentasi. Dalam penelitian ini menggunakan teknik analisis data denganreduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian dalam penelitian ini dapat diketahui: 1) masyarakat desa Delo mempergunakan padi sebagai simbol atau perantara kepercayaan marapu dalam ritual saiso, dengan cara mengibaratkan padi sebagai manusia yang memiliki jiwa, yang perlu dijagah, dan dipelihara karena pada dasarnya masyarakat desa Delo masih sebagian yang menganut agama atau kepercayaan lokal yaitu kepercayaan marapu. Oleh karena itu, masyarakat desa Delo masih sangat kental dengan budaya adat serta tidak mau terlepas dengan adat dan juga ritual-ritual adat ini merupakan tradisi yang diwariskan para pendahulu sehingga sampai saat ini juga masyarakat tersebut tetap melestarikannya. 2) masyarakat desa Delo mempertahankan penggunaan bahasa adat atau syair sumba ( bahasa teda) dalam kebudayaan ritual saiso dengan cara para generasi muda berpartisipasi dalam setiap kegiatan adat agar mereka melihat, mendengar, dan menyaksikan parah tokoh, karena para generasi muda merupakan penerus atau pewaris kebudayaan adat yang ada didaerah tertentu khususnya di sumba.
A EFEKTIVITAS PENGAJARAN MENULIS TEKS RECOUNT DENGAN MENGGUNAKAN TIKTOK UNTUK SISWA KELAS SEPULUH SMA HASANUDDIN WAJAK
Authors: Khasanah Ulfatul , Fitriani Enis , Jasuli Jasuli
Published: August 2023

EFEKTIVITAS PENGAJARAN MENULIS TEKS RECOUNT DENGAN MENGGUNAKAN TIKTOK UNTUK SISWA KELAS SEPULUH SMA HASANUDDIN WAJAK

Ulfatul Khasanah1, Enis Fitriani2, Jasuli3

1Pendidikan Bahasa Inggris, IKIP Budi Utomo Malang

e-mail : ulfatulksn@gmail.com

2 Pendidikan Bahasa Inggris, IKIP Budi Utomo Malang

e-mail : fitrianienis@gmail.com

3 Pendidikan Bahasa Inggris, IKIP Budi Utomo Malang

e-mail : Jasuli@budiutomomalang.ac.id

 

Informasi Artikel

ABSTRACT

Submit : 06-08-2022

Diterima : xx-xx-2022

Dipublikasikan : xx-xx-2022

This research is aimed to determine whether classes taught using Tiktok have better results than classes taught without using Tiktok. Students today are familiar with Tiktok because of its easy and flexible access. By using Tiktok students can create their writings so that they are more interesting to read and can be seen by many people. This is a quasi-experimental research. The experimental group was taught using Tiktok and the control group was taught without using Tiktok. The author used a pre-test to find out that both groups had relatively the same background knowledge in the research variables and a post-test to find an increase in scores as a measure of achievement. The author uses tests to calculate and hypothesize.

 

Keywords : Writing, Recount Text, Tiktok

 

 

Penerbit

ABSTRAK

IKIP Budi Utomo

Penelitian ini bertujuan untuk mengetahui apakah kelas yang diajarkan menggunakan Tiktok memiliki hasil yang lebih baik dibandingkan dengan kelas yang diajar tanpa menggunakan Tiktok. Siswa pada era sekarang banyak mengenal Tiktok karena aksesnya yang mudah dan fleksibel. Dengan menggunakan Tiktok siswa dapat mengreasikan hasil tulisannya agar lebih menarik untuk dibaca dan dapat dilihat banyak orang. Ini adalah penilitian quasi eksperimen. Kelompok eksperimen diajar dengan menggunakan Tiktok dan kelompok kontrol diajar tanpa menggunakan Tiktok. Penulis menggunakan pre-test untuk mengetahui bahwa kedua kelompok mempunyai latar belakang pengetahuan yang relatif sama dalam variable penelitian dan post-test untuk menemukan peningkatan nilai sebagai ukuran prestasi. Penulis menggunakan test untuk menghitung dan menghipotesis.

 

Kata Kunci : Menulis, Teks Recount, Tiktok
ANALISIS GAYA BAHASA PERBANDINGAN DALAM NOVEL CINTA BEDA AGAMA DAN BUDAYA KARYA ROSYIDAH KHOLIL
Authors: Yulianto Amin Dwi Yulianto Amin
Published: August 2023

Abstract: This study aims to describe and analyze the types of comparative language style analysis in the novel love of different religions and cultures by Rosyidah Kholil. This study uses a qualitative approach. The object of this research is in the form of words, phrases, sentences or paragraphs in the love novels of different religions and cultures. The data analysis procedure is carried out by classifying the data based on the type of language style, examining the data one by one and matching it with the theory, then describing the data that has been studied. This study finds comparative language styles (parables, metaphors, personifications, allegory, antithesis, pleonasm and tautology, perifascist, anticipation). The style of language is a means for the writer to give a certain emphasis to the issues that the writer wants to convey, strengthen the reader's impression of an event or character in the story, bring the story to life, and beautify the story.
İNTERNETİN FONKSİYONEL OLMAYAN TALEBE ETKİSİ ÜZERİNE BİR ARAŞTIRMA
Authors: Hüsnüoğlu Nadide
Published: August 2023

Teknolojinin ve internetin gelişmesi hayatımızın her alanını etkilediği gibi ürün talebini de etkilemekte ve internetten alışveriş her geçen gün artmaktadır. Bu çalışmanın amacı, Bandwagon etkisi, Veblen etkisi, Snob etkisi, kıtlık algısı, indirim mesajları, sosyal medya, koronavirüs, enflasyon gibi yönlerden internetin fonksiyonel olmayan talebe etkisini analiz etmektir. Çalışmada 384 üniversite öğrencisine uygulanan veriler SPSS paket programı ile frekans analizi, ki kare testleri, faktör analizi ve regresyon analizi ile incelenmiştir. Elde edilen sonuçlara göre koronavirüs döneminde internetten alışveriş artmış olup en fazla alınan ürün giyim/ayakkabı grubunda olmuştur. Faktör analizi ile altı faktör boyutu belirlenmiştir. Regresyon analiz sonucuna göre, ekonomi bağımlı değişkeni ile bağımlılık, bandwagon ve sosyal medya bağımsız değişkenleri arasında pozitif yönlü ve anlamlı bir ilişki bulunmuştur. İnternet alışverişinde ekonomik koşullar en fazla bağımlılık durumundan etkilenmektedir. Bu sonuç bağımlılık arttığında internetten alışverişte ekonomik faktörlere duyarlılık daha fazla artmaktadır şeklinde yorumlanabilir. Regresyon analizinde kullanılan bağımlı
ve bağımsız değişkenler faktör analiziyle elde edilen ilgili değişkenlerin faktör puanlarının toplamıdır.
KAMU YÖNETİMİNDE DAVRANIŞSAL YAKLAŞIM VE BİRLEŞİK KRALLIK DAVRANIŞSAL İÇGÖRÜLER EKİBİ ÖRNEĞİ
Authors: Yelkesen Elmas , Bankoğlu Hatice Duygu
Published: August 2023

Kamu yönetimi alanında insanı anlama çabası, davranışsal yaklaşımın kuramsal temelinin atıldığı 20. yüzyılda başlamıştır. Günümüzde bu yaklaşım kamu yönetiminde psikolojik bakış açısını kullanmanın politika uygulayıcılarına pratik fayda sağladığı düşüncesiyle tekrar gündeme gelmiştir. Kamu yönetimi alanında bu konudaki çalışmalar insan davranışlarını ve tutumlarını gözlemleyebilmek, ölçebilmek ve yönlendirebilmek amacıyla yapılan yönetsel uygulamalarla “davranışsal içgörüler” ekseninde sürdürülmektedir. Bu nedenle çalışmada davranışsal içgörülerin kamu yönetimi alanıyla ilişkisi davranışsal yaklaşımın alandaki tarihsel gelişimi üzerinden ele alınmıştır. Ayrıca çalışmada davranışsal içgörülerin kamu yönetiminde ilk uygulama birimi olan “Davranışsal İçgörüler Ekibi (Behavioural Insights Team)” örnek olarak incelenmiştir. Çalışma bu ilişkide ekibin kuruluşu, uygulamaları ve dönüşümü esas alınarak davranışsal içgörülerin nasıl görünür hale
geldiği sorusunu cevaplamayı amaçlamaktadır. Bu bağlamda ekibin kabine ofisinin bir alt birimi olarak örgütlenmesi, 2014’te ise alt birim olmaktan çıkıp şirketleşmesi dikkat çekicidir. Ancak Birleşik Krallık ekibin ortaklığını 2021’e kadar devam ettirmiştir. Ekibin geçirmiş olduğu bu değişimler içgörülerin kullanımında devletin yönlendiriciliğinin değiştiği sonucunu ortaya çıkarmıştır.
ANALISIS RESPON MAHASISWA TERHADAP PENGGUNAAN E-MODUL PRAKTIKUM IPA DI SD PADA PEMBELAJARAN JARAK JAUH
Authors: Budiastra A. A. Ketut , Wicaksono Iwan
Published: August 2023

Bentuk penelitian yang diterapkan dalam kajian ini adalah penelitian kuantitatif. Adapun metode penelitian yang digunakan adalah survei. Instrumen penelitian menggunakan angket respon mahasiswa. Responden yang mengikuti pengisian angket adalah 65 mahasiswa. Terdapat tiga aspek yang dinilai oleh siswa, yakni: aspek tampilan, aspek penyajian materi, dan aspek manfaat dengan total pernyataan adalah 16 item pernyataan. Setelah data dikumpulkan dan diolah, diperoleh hasil bahwa respon mahasiswa terhadap E-modul Praktikum IPA adalah sangat positif, baik dari aspek tampilan, penyajian materi, dan manfaat. Beberapa faktor yang membuat siswa memberikan respon sangat positif memberikan hasil presentase 81,3 % dengan kriteria sangat kuat. Respon mahasiswa terhadap penggunaan E-Modul Praktikum IPA di SD digolongkan menjadi tiga indikator meliputi: kesesuaian E-Modul dengan praktikum, penggunan software yang sesuai untuk E-modul, dan mendorong kemandirian mahasiswa. Implikasi respon mahasiswa ini memberikan potensi penggunaan E-modul Praktikum IPA dalam pembelajaran jarak jauh di Universitas Terbuka.
PEMANFAATAN MEDIA DIGITAL DALAM PROSES PEMBELAJARAN DI KELAS X SMK NEGERI 1 BUSUNGBIU
Authors: Dewi Kadek Rusma , Korompis Ferry Lourens S.
Published: August 2023

Penelitian ini bertujuan untuk mengetahui pemanfaatan media digital dalam proses pembelajaran di kelas X SMK Negeri 1 Busungbiu. Penelitian ini dilakukan dengan menggunakan metode penelitian deskriptif kualitatif dengan teknik pengumpulan data melalui observasi, wawancara, dan studi literatur. Penelitian ini melibatkan 30 responden yang terdiri dari guru dan siswa di kelas X SMK Negeri 1 Busungbiu. Hasil penelitian menunjukkan bahwa pengembangan media digital dapat meningkatkan proses pembelajaran di kelas X di SMK Negeri 1 Busungbiu. Hal ini terlihat dari peningkatan minat dan motivasi belajar siswa, efektivitas waktu pembelajaran, serta hasil belajar yang lebih baik. Selain itu, penggunaan media digital juga membantu meningkatkan kemampuan kognitif dan keterampilan teknologi siswa. Kesimpulan dari penelitian ini adalah pemanfaatan media digital dapat meningkatkan proses pembelajaran di kelas X SMK Negeri 1 Busungbiu. Oleh karena itu, diharapkan pihak sekolah dapat memberikan perhatian lebih terhadap pengembangan media digital dalam proses pembelajaran. Selain itu, diperlukan kerja sama antara guru dan siswa untuk memaksimalkan penggunaan media digital dalam pembelajaran.
Gratis undervisningsresurser från industriföretag kräver didaktiska överväganden
Authors: Andrée Maria , Hansson Lena
Published: August 2023

Det finns många olika aktörer som engagerar sig i skolans undervisning i naturvetenskap och teknik – inte minst från industrin. I denna artikel presenterar vi resultat från vårt forskningsprojekt som visar att detta kan innebära intressekonflikter mellan privata och allmänna intressen. Vi presenterar även ett ramverk från samma projekt som kan fungera som stöd för lärare för att göra didaktiska överväganden kring denna typ av undervisningsresurser.
Modeling the early phases of epidemics by Phakospora pachyrhizi in Brazilian soybean
Authors: Kassie Belay T. , Onstad David W. , Koga Lucimara , Hart Tim , Clark Randy , van der Heijden Gerie
Published: August 2023

Asian soybean rust, caused by the biotrophic basidiomycete Phakospora pachyrhizi, is a foliar disease that often causes considerable damage to soybean crops. The purpose of our work was to create a mechanistic model that can reliably represent epidemics of ASR in commercial soybean fields in Brazil. The most important inputs for the model are weather data (observations and forecast) and the initial observation of disease (or uredospore arrival). Our focus is on the first two or three cycles of infection after immigration into a soybean field. The model includes state variables for latent, infectious and senesced lesions, disease severity, uredospores, and soybean leaf area. Processes modeled include maturation through the latent and infectious periods, germination, sporulation, and processes affecting uredospores in the canopy. The model results were tested against field observations from trials at four locations in Brazil for the 2019/2020 growing season. The predictions generally matched the daily dynamics of disease progress in the field trials. The predictions reproduced the observed severity well with R2 value of 0.84. This high correlation indicates that our model is accurate enough to be used as a tool to predict the dynamics of ASR epidemics during the first few cycles after uredospore invasion into a soybean field. A sensitivity analysis was performed that showed that the model is sensitive to time and duration of the initial spore arrival. This indicates that spore traps or other observations should measure not only the first day of arrival but also subsequent days.
Effect of dietary energy source on pregnancy rates and reproductive physiology of pastured beef heifers
Authors: Davis Ty C. , Amirault Katherine E. , Stewart Jacob W. , Gleason Claire B. , Dias Nicholas W. , Timlin Claire L. , Seekford Zachary K. , Ealy Alan D. , Mercadante Vitor R. G. , White Robin R.
Published: August 2023

Proper production of steroid hormones, such as progesterone (P4), is essential for maintenance of pregnancy. Provision of gluconeogenic substrates from the diet may alter postabsorptive energy supplies and associated hormone signaling in a manner supportive of elevating P4 concentrations. Crossbred Angus heifers (n=27) were balanced for pre-trial bodyweight (BW) and body condition score (BCS), then assigned to isoenergetic diets leveraging starch (ES) or fat (EF) as the primary source of energy (45.7% starch vs 11.5% fat). The heifers were placed on the assigned diets 8 days prior to the initiation of estrous synchronization and continued the diets through the second pregnancy diagnosis, 52 days after the initial insemination. On day 28 post-breeding, pregnancy status was diagnosed via ultrasonography. Measurements of follicle size and number were collected via rectal palpation and ultrasonography on days −10, −8, −4, and day 0 relative to breeding. Blood samples were collected on days −10, 1 through 7, 10, 14, 18, 21, 24, and 28 to analyze plasma for P4 concentrations and placental-associated glycoprotein (PAG) concentrations. Data were analyzed using a linear mixed effects model with a fixed effect for treatment and a random effect for pen. Observations collected over time were analyzed using a repeated measures approach with fixed effects for treatment, time, initial condition, and a random effect for pen. Interactions between treatment and pregnancy status were also tested for PAG and P4 concentrations. No treatment differences were observed in final BCS (P=0.12) and total dry matter intake (DMI; P=0.51), though heifers on the ES treatment tended to reach an increased BW (P=0.10). Although heifers fed ES diets had numerically higher conception rates compared to heifers fed EF diets (71.4% vs. 66.7%), there was no statistically significant difference. Furthermore, there were no significant differences observed among diets in terms of pregnancy outcomes, follicle size, or number. A treatment by pregnancy status interaction was detected for both PAG and P4 concentrations. These results suggest that short-term dietary starch supplementation provided around the time of breeding can result in shifts to reproductive hormone abundance that may be conducive for pregnancy establishment.
Dual effectiveness of a novel all-in-one endodontic irrigating solution in antibiofilm activity and smear layer removal
Authors: Sheng Xuyan , Yu Jian , Liu He , Wang Zhejun , Deng Shuli , Shen Ya
Published: August 2023

The continuous destruction of dental hard tissues increases the risk of bacterial invasion, which leads to pulp infections. Irrigation is critical for successful root canal treatment in terms of infection control. However, no single irrigant covers all of the functions demanded, including antibiofilm and tissue-dissolving activities. The aim of this study was to investigate the antimicrobial properties of Triton, an all-in-one irrigant, on Enterococcus faecalis and multispecies oral biofilms in dentin canals, as well as its ability to remove the smear layer. Dentin blocks (192 specimens) were prepared from single-root human teeth and then assigned to 48 groups (24 groups for each biofilm type). Serial centrifugation was used for bacterial introduction into dentinal tubules. After 3 weeks, half of the specimens were created a uniform smear layer. The following treatments were applied: short time (separate): Triton, 6% NaOCl, 2% NaOCl, and water (all for 3 min); short time (combined): Triton (3 + 1 min), 6% NaOCl +17% EDTA (3 + 1 or 2 + 1 min), and 2% NaOCl +17% EDTA (3 + 1 min); and long time: Triton (3 + 3 min), 6% NaOCl (5 min), 6% NaOCl +17% EDTA (5 + 1 min), and water (3 + 3 min). Confocal laser scanning microscopy and scanning electron microscopy were employed to examine the antimicrobial activity and smear layer removal, respectively. The results revealed that despite the absence or presence of the smear layer, Triton (3 + 3 min) showed the highest killing for both tested biofilms (61.53%–72.22%) among all groups (p < 0.05). Furthermore, the smear layer was removed by Triton after 3 + 3 min, exposing open dentin canals. These findings demonstrated that Triton can provide dual benefits of antibiofilm and smear layer removal capabilities simultaneously, indicating a simplified and effective strategy for application in root canal treatment.
Whole genome sequence and diversity in multigene families of Babesia ovis
Authors: Yamagishi Junya , Ceylan Onur , Xuan Xuenan , Sevinc Ferda
Published: August 2023

Ovine babesiosis, caused by Babesia ovis, is an acute, lethal, and endemic disease worldwide and causes a huge economic loss to animal industry. Pathogen genome sequences can be utilized for selecting diagnostic markers, drug targets, and antigens for vaccine development; however, those for B. ovis have not been available so far. In this study, we obtained a draft genome sequence for B. ovis isolated from an infected sheep in Turkey. The genome size was 7.81 Mbp with 3,419 protein-coding genes. It consisted of 41 contigs, and the N50 was 526 Kbp. There were 259 orthologs identified among eight Babesia spp., Plasmodium falciparum, and Toxoplasma gondii. A phylogeny was estimated on the basis of the orthologs, which showed B. ovis to be closest to B. bovis. There were 43 ves genes identified using hmm model as well. They formed a discriminating cluster to other ves multigene family of Babesia spp. but showed certain similarities to those of B. bovis, B. caballi, and Babesia sp. Xinjiang, which is consistent with the phylogeny. Comparative genomics among B. ovis and B. bovis elucidated uniquely evolved genes in these species, which may account for the adaptation.
Heart failure in erythrodermic psoriasis: a retrospective study of 225 patients
Authors: Wu Chao , Yu Chenyang , Yang Yuyan , Jin Hongzhong
Published: August 2023

Purpose

Erythrodermic psoriasis (EP) is a severe form of psoriasis that affects multiple organs, including the cardiovascular system. However, few studies have focused on this condition.This study is aimed to assess the prevalence and factors associated with heart failure in EP patient, and to the measure the serum concentrations of fibroblast growth factor 23 (FGF23), a potential predictor of chronic heart failure.

Methods

We retrospectively studied patients with EP hospitalized at Peking Union Medical College Hospital between January 2005 to October 2021. The prevalence of heart failure and associated factors was measured. In addition, peripheral blood samples were collected from 17 patients and matched with samples from eight healthy controls, and their serum concentrations of FGF23 were measured by ELISA.

Results

We studied 225 patients with EP, with a male: female ratio of 2.7:1 and a mean age of 47.6 ± 16.7 years. Twenty-five (11.1%) participants were diagnosed with heart failure during their hospital stay. The patients with EP and heart failure were older (58.2 years vs. 46.2 years, p = 0.001); had a higher prevalence of a history of coronary heart disease (32.0% vs. 21.5%, p < 0.001), fever (48.0% vs. 23.0%, p = 0.007), infection (56.0% vs. 35.5%, p = 0.046); higher hsCRP concentration (43.2 mg/L vs. 8.2 mg/L, p = 0.005); and higher prevalence of anemia (60.0% vs. 22.0%, p < 0.001), hypoalbuminemia (64.0% vs. 42.0%, p = 0.037), and hyperlipidemia (40.0% vs. 20.0%, p = 0.023) than those without heart failure. The serum FGF23 concentration was significantly higher in patients with EP than controls (493.1 pg/ml vs. 277.8 pg/ml, p = 0.027), and was significantly lower after treatment (395.7 pg/ml vs. 463.1 pg/ml, p = 0.022).

Conclusions

Clinicians should be aware of the risk of heart failure in patients with EP, and especially those of advanced age and with a history of coronary heart disease, severe systemic symptoms, high concentrations of inflammatory biomarkers, and poor nutritional status.
Case report: Left atrial myxoma with morphology of cavernous hemangioma supplied by the right coronary artery
Authors: Zhang Shouji , Wang Junlin , Song Fahang , Yang Fan , Li Fang , Liu Shangxin , Ma Jiwei , Zhang Haizhou , Ma Xiaochun
Published: August 2023

Here, we report an unusual case of left atrial myxoma presented with morphology of cavernous hemangioma supplied by the right coronary artery. Surgical resection of the left atrium myxoma was performed, and the patient experienced an uneventful recovery during hospitalization.
Research trends in cardiovascular tissue engineering from 1992 to 2022: a bibliometric analysis
Authors: Lai Ping , Sheng Ming , Ye Jin-hua , Tang Zhi-xian , Hu Shuo , Wang Bei , Yuan Jing-lin , Yang Yi-hong , Zhong Yi-ming , Liao Yong-ling
Published: August 2023

Background

Cardiovascular tissue engineering (CTE) is a promising technique to treat incurable cardiovascular diseases, such as myocardial infarction and ischemic cardiomyopathy. Plenty of studies related to CTE have been published in the last 30 years. However, an analysis of the research status, trends, and potential directions in this field is still lacking. The present study applies a bibliometric analysis to reveal CTE research trends and potential directions.

Methods

On 5 August 2022, research articles and review papers on CTE were searched from the Web of Science Core Collection with inclusion and exclusion criteria. Publication trends, research directions, and visual maps in this field were obtained using Excel (Microsoft 2009), VOSviewer, and Citespace software.

Results

A total of 2,273 documents from 1992 to 2022 were included in the final analysis. Publications on CTE showed an upward trend from 1992 [number of publications (Np):1] to 2021 (Np:165). The United States (Np: 916, number of citations: 152,377, H-index: 124) contributed the most publications and citations in this field. Research on CTE has a wide distribution of disciplines, led by engineering (Np: 788, number of citations: 40,563, H-index: 105). “Functional maturation” [red cluster, average published year (APY): 2018.63, 30 times], “cell-derived cardiomyocytes” (red cluster, APY: 2018.43, 46 times), “composite scaffolds” (green cluster, APY: 2018.54, 41 times), and “maturation” (red cluster, APY: 2018.17, 84 times) are the main emerging keywords in this area.

Conclusion

Research on CTE is a hot research topic. The United States is a dominant player in CTE research. Interdisciplinary collaboration has played a critical role in the progress of CTE. Studies on functional maturation and the development of novel biologically relevant materials and related applications will be the potential research directions in this field.
Effects of vitamin D supplementation on ovulation and pregnancy in women with polycystic ovary syndrome: a systematic review and meta-analysis
Authors: Yang Meina , Shen Xiaoyang , Lu Danhua , Peng Jin , Zhou Siyu , Xu Liangzhi , Zhang Jing
Published: August 2023

Objective

To evaluate the effect of vitamin D supplementation on pregnancy and ovulation in patients with polycystic ovary syndrome.

Method

We searched Pubmed, Medline (via Ovid, 1974 to 2020), EMBASE (via Ovid, 1974 to 2020), Cochrane Central Register of Controlled Trials (via Ovid), Web of Science, CNKI, WangFang and the Vip database from inception until April 2021. Two researchers independently screened articles, collected data and evaluated the quality, with Review manager 5.3 for meta-analysis.

Results

Totally 20 randomized controlled studies with 1961 subjects were included. Meta analysis showed that pregnancy rate [RR=1.44 (1.28, 1.62), p<0.00,001], ovulation rate [RR=1.42 (1.14, 1.78), p=0.002] and matured oocytes rate [RR=1.08 (1.03, 1.13), p=0.002] of vitamin D supplementation group were significantly higher than those of control group. Meanwhile, early miscarriage rate [RR=0.44 (0.30, 0.66), p<0.00,001], androgen level [MD=-2.31 (-3.51, -1.11), p=0.0002], luteinizing hormone [MD=-1.47 (-2.57, -0.36), p=0.009], follicle stimulating hormone [MD=-0.15 (-0.24, -0.05), p=0.002], and premature delivery rate [RR=0.38, 95% CI (0.21, 0.70), p=0.002] were declined significantly than the controls. However, only one article suggested that the progesterone [MD=6.52 (4.52, 8.52), p<0.05] in the vitamin D intervention group was increased. There was no notable difference in the biochemical pregnancy rate [RR=0.95 (0.55, 1.63), p=0.84], gestational hypertension rate [RR=0.40, 95% CI (0.15, 1.11), p=0.08], gestational diabetes mellitus rate [RR=0.27, 95% CI (0.05, 1.39), p=0.11], fertilization rate [RR=1.05 (1.00, 1.10), p=0.04], cleavage rate [RR=1.03 (0.99, 1.06), p=0.17], high-quality embryo rate [RR=1.08 (0.98, 1.20), p=0.10], endometrial thickness [MD=0.10], 77 (-0.23, 1.77), p=0.13], estrogen level [MD=-0.34 (-1.55, 0.87), p=0.59], LH/FSH [MD=-0.14, 95% CI (-0.48, 0.20), p=1.00] and anti-Mullerian hormone [MD=-0.22 (-0.65, 0.21), p=0.32].

Conclusion

Vitamin D supplementation contribute to the higher pregnancy and ovulation rates, and lower androgen, LH, FSH and early miscarriage rates in women with PCOS, regardless of the use of ovulation induction drugs or assisted reproductive technologies. However, no significant improvement was observed in fertilization rate or cleavage rate. Due to the limitation in quality of involved studies, more high-quality RCTs are needed for further validation.

Systematic review registration

https://www.crd.york.ac.uk/PROSPERO, identifier CRD42021250284.
Premature ovarian insufficiency: a review on the role of oxidative stress and the application of antioxidants
Authors: Shi Yu-Qian , Zhu Xi-Ting , Zhang Su-Na , Ma Yi-Fu , Han Yan-Hua , Jiang Yue , Zhang Yue-Hui
Published: August 2023

Normal levels of reactive oxygen species (ROS) play an important role in regulating follicular growth, angiogenesis and sex hormone synthesis in ovarian tissue. When the balance between ROS and antioxidants is disrupted, however, it can cause serious consequences of oxidative stress (OS), and the quantity and quality of oocytes will decline. Therefore, this review discusses the interrelationship between OS and premature ovarian insufficiency (POI), the potential mechanisms and the methods by which antioxidants can improve POI through controlling the level of OS. We found that OS can mediate changes in genetic materials, signal pathways, transcription factors and ovarian microenvironment, resulting in abnormal apoptosis of ovarian granulosa cells (GCs) and abnormal meiosis as well as decreased mitochondrial Deoxyribonucleic Acid(mtDNA) and other changes, thus accelerating the process of ovarian aging. However, antioxidants, mesenchymal stem cells (MSCs), biological enzymes and other antioxidants can delay the disease process of POI by reducing the ROS level in vivo.
Area deprivation and demographic factors associated with diabetes technology use in adults with type 1 diabetes in Germany
Authors: Auzanneau Marie , Eckert Alexander J. , Meyhöfer Sebastian M. , Heni Martin , Gillessen Anton , Schwettmann Lars , Jehle Peter M. , Hummel Michael , Holl Reinhard W.
Published: August 2023

Introduction

Diabetes technology improves glycemic control and quality of life for many people with type 1 diabetes (T1D). However, inequalities in access to diabetes technology exist in many countries. In Germany, disparities in technology use have been described in pediatric T1D, but no data for adults are available so far. We therefore aimed to analyze whether demographic factors and area deprivation are associated with technology use in a representative population of adults with T1D.

Materials and methods

In adults with T1D from the German prospective diabetes follow-up registry (DPV), we analyzed the use of continuous subcutaneous insulin infusion (CSII), continuous glucose monitoring (CGM), and sensor augmented pump therapy (SAP, with and without automated insulin delivery) in 2019-2021 by age group, gender, migration background, and area deprivation using multiple adjusted regression models. Area deprivation, defined as a relative lack of area-based resources, was measured by quintiles of the German index of Multiple Deprivation (GIMD 2015, from Q1, least deprived, to Q5, most deprived districts).

Results

Among 13,351 adults with T1D, the use of technology decreased significantly with older age: CSII use fell from 56.1% in the 18−<25-year age group to 3.1% in the ≥80-year age group, CGM use from 75.3% to 28.2%, and SAP use from 45.1% to 1.5% (all p for trend <0.001). The use of technology was also significantly higher in women than in men (CSII: 39.2% vs. 27.6%; CGM: 61.9% vs. 58.0%; SAP: 28.7% vs. 19.6%, all p <0.001), and in individuals without migration background than in those with migration background (CSII: 38.8% vs. 27.6%; CGM: 71.1% vs. 61.4%; SAP: 30.5% vs. 21.3%, all p <0.001). Associations with area deprivation were not linear: the use of each technology decreased only from Q2 to Q4.

Discussion

Our real-world data provide evidence that higher age, male gender, and migration background are currently associated with lower use of diabetes technology in adults with T1D in Germany. Associations with area deprivation are more complex, probably due to correlations with other factors, like the higher proportion of migrants in less deprived areas or the federal structure of the German health care system.
Evaluation of bone mineral density and bone turnover in children on anticoagulation
Authors: Thom Katharina , Patsch Janina Maria , Haufler Florentina , Pees Christiane , Albinni Sulaima , Weber Michael , Male Christoph , Raimann Adalbert
Published: August 2023

Background

Childhood and adolescence are critical periods of bone mineral acquisition. Children on anticoagulation (AC) might have an increased risk for reduced bone mineral density (BMD). Risk factors for impaired bone accumulation include chronic diseases, immobility, and medication. Vitamin K (VK) deficiency reflected by undercarboxylated osteocalcin levels (ucOC) has been identified as a predictor of osteoporosis and fractures. Data on bone health in children under AC are sparse.

Aims

To evaluate BMD in children on AC and characterize the risk factors of low BMD, including VK and Vitamin D (VD) status.

Methods

Single-center cross-sectional study of clinical, biochemical, and densitometric parameters. Assessment of VK surrogate parameters included ucOC and matrix gla protein (MGP).

Results

A total of 39 children (4–18 years; 12 females) receiving AC were included, 31 (79%) on VK antagonists and 8 (21%) on direct oral anticoagulants. Overall, BMD was decreased for both the lumbar spine (LS; −0.7SDS) and total body less head (TBLH; −1.32SDS) compared with pediatric reference data. Significant associations were found between early pubertal development and TBLH-BMD, and between BMI and LS-BMD. VK surrogate parameters were highly related to patients’ age and pubertal development. Neither serum parameters nor AC-related factors predicted BMD. VD was detected in 10/39 patients with lower values during puberty.

Conclusion

Our data indicate BMD reduction in pediatric patients on AC. Although AC-related factors did not predict reduced BMD, low BMI and pubertal stages represented important risk factors. Awareness of risk factors for low BMD and high prevalence of VD deficiency during puberty could contribute to the improvement of bone health in this vulnerable patient group.
Effect of 10.6 μm laser moxibustion on inflammation in diabetic peripheral neuropathy rats
Authors: Yin Yue , Wang Lina , Zhao Ling , Lin Lin , Shen Xueyong
Published: August 2023

Diabetic peripheral neuropathy (DPN) is the main cause of disability in diabetes patients but the efficacy of available drugs is poor. Moxibustion is an adjunctive treatment for DPN that can reduce symptoms. The peak value of the far infrared wavelength of 10.6 μm laser moxibustion is close to the infrared radiation spectrum of traditional moxibustion. Its effect is similar to that of moxibustion and does not cause pain, infection or produce irritating smoke. Twenty-four male SD rats were divided into control (Con), DPN, laser moxibustion (LM), and pyrrolidine dithiocarbamate (PDTC) groups (n=6/group). The DPN, LM and PDTC group rats were intraperitoneally injected with 1% streptozotocin (STZ) to induce a model of DPN. LM group rats were irradiated with a laser at bilateral ST36 acupoints for 15 min, once every other day, for 14 days. PDTC group rats were intraperitoneally injected with PDTC once a day. Body weight, blood glucose, and paw withdrawal mechanical threshold (PWMT) were measured and laser speckle imaging (LSI) performed before and after modeling and at 1 and 2 weeks after intervention. Two weeks after intervention, changes in serum interleukin 1β (IL1β), interleukin 6 (IL6), tumor necrosis factor α (TNFα) and nerve growth factor (NGF) were analyzed, and the abundance of NF-κB and IκB-α proteins and levels of NF-κB and IκB-α mRNAs in the sciatic nerve were observed. The results showed that 10.6 μm laser moxibustion can relieve pain, improve microcirculation, and alleviate inflammation in DPN rats, possibly via the NF-κB inflammatory pathway.
Ontogenetic changes in green turtle (Chelonia mydas) diet and home range in a tropical lagoon
Authors: Vanderklift Mathew A. , Pillans Richard D. , Rochester Wayne , Stubbs Jessica L. , Skrzypek Grzegorz , Tucker Anton D. , Whiting Scott D.
Published: August 2023

Ontogenetic changes in habitat and diet are widespread among marine species. Most species of sea turtles are characterized by extreme ontogenetic changes in habitat use and diet, with large changes occurring in early developmental stages (e.g., neonates to juveniles). Changes can continue even after recruitment to shallow coastal habitats. In places where substantial transitions in habitat occur across short distances, it is possible that the distances of developmental movements from one habitat to another could be short. We investigated ontogenetic changes in home range size, home range location and diet of Chelonia mydas in a tropical coastal lagoon in north-western Australia by combining acoustic telemetry with stable isotope analysis. There was a substantial (but nonlinear) increase in home-range size (kernel utilization distribution: KUD) with length, and an increase in the average distance of the center of home ranges from shore with length: larger turtles tended to occupy larger areas further from the shore. These patterns were accompanied by complex nonlinear changes in δ13C, δ15N and δ34S of red blood cells and nails; changes were rapid from 36 cm (the length of the smallest individual captured) to 50 cm, before reversing more gradually with increasing size. δ15N and δ34S (but not δ13C) of red blood cells and nails increased monotonically with KUD and distance from shore. Seagrass was likely an important food for all sizes, macroalgae was potentially important for small (< 60 cm CCL) individuals, and the proportion of scyphozoan jellyfish in diet increased monotonically with size. The combination of acoustic telemetry and stable isotope analysis revealed ontogenetic shifts in use of space and diet across short distances in a tropical coastal lagoon.
Evidence that traffic noise increases territorial response in vermilion flycatchers
Authors: Chavez-Mendoza Nayeli Evelin , José-Ramírez Sandra , Ríos-Chelén Alejandro Ariel
Published: August 2023

Animals vocalize in particular ways in noise, presumably to increase the probability of detection; however, this idea has been seldom put to the test. Vermilion flycatchers produce longer songs in noisy territories. To test the hypothesis that longer songs increase the probability of detection in noise, we ran a field playback experiment on 30 free-living males. Each male was exposed to two treatments with the same songs, but one treatment had traffic noise and the other had no noise. Half of males were exposed to short songs (with four introductory elements – IE) and half to long songs (eight IE). If long songs have a higher probability of detection in noise, we expected that the experimental noise would have little effect when males heard long songs, but a larger effect when they heard short songs (i.e. significant interaction between song length and treatment). We measured call and flight responses, latencies to call and fly, and closest approach to the speaker. We also measured ambient traffic noise in the males’ territories to evaluate a possible association with their responses. Males did not respond differently to long vs short songs; more importantly, the predicted interaction between song length and treatment was not found. Our results, do not support the hypothesis that long songs are detected with a higher probability in noise. Interestingly, males increased their call response as ambient noise increased in their territories. Males also showed a non-significant trend to increase their flight respond toward long songs with experimental noise than to long songs without noise. Our results strongly suggests that noise amplifies territorial response, which may affect the outcome of territorial competition.
Computational analysis of heat shock proteins and ferroptosis-associated lncRNAs to predict prognosis in acute myeloid leukemia patients
Authors: Ge Fangfang , Wang Yulu , Sharma Amit , Jaehde Ulrich , Essler Markus , Schmid Matthias , Schmidt-Wolf Ingo G. H.
Published: August 2023

Owing to their functional diversity in many cancers, long noncoding RNAs (lncRNAs) are receiving special attention. LncRNAs not only function as oncogenes or tumor suppressors by participating in various signaling pathways but also serve as predictive markers for various types of cancer, including acute myeloid leukemia (AML). Considering this, we investigated lncRNAs that may act as a mediator between two processes, i.e., heat shock proteins and ferroptosis, which appear to be closely related in tumorigenesis. Using a comprehensive bioinformatics approach, we identified four lncRNAs (AL138716.1, AC000120.1, AC004947.1, and LINC01547) with prognostic value in AML patients. Of interest, two of them (AC000120.1 and LINC01547) have already been reported to be AML-related, and AC004947.1 is considered to have oncogenic potential. In particular, the signature obtained showed a lower survival probability with high-risk patients, and vice versa. To our knowledge, this is the first predictive model of lncRNA that may correlate with the processes of heat shock proteins and ferroptosis in AML. Nevertheless, validation using patient samples is warranted.
The causal effect of inflammatory bowel disease on diffuse large B-cell lymphoma: two-sample Mendelian randomization study
Authors: Lu Chuanyang , Chen Qiuni , Tao Hong , Xu Lei , Li Jiaxin , Wang Chunling , Yu Liang
Published: August 2023

Background

It has been reported that inflammatory bowel disease (IBD) is associated with an increased risk of malignancies, including lymphoma. A number of large observational studies have been devoted to exploring the causal link between IBD and malignant lymphoma. However, no consensus exists on whether there is a causal relationship between IBD and malignant lymphoma.

Methods

The summary dataset of the IBD and lymphoma genome-wide association studies (GWAS) was obtained from the OPEN GWAS website. Single-nucleotide polymorphisms (SNPs) were selected as genetic instrumental variants (IVs) for fulling P < 5 × 10-8 and linkage disequilibrium (LD) of r2 = 0.001 in the IBD GWAS. The proxy SNPs with LD of r2 > 0.8 were identified. Palindromic SNPs and outlier SNPs were excluded. The assessments of sensitivity employed the Cochran’s Q test, Mendelian randomization (MR)-Egger intercept test, and leave-one-out analysis.

Results

The MR analysis results proved the causality of IBD on diffuse large B-cell lymphoma (DLBCL). The risk of developing DLBCL is increased by 28.6% in patients with IBD [odds ratio (OR)IVW = 1.286, 95% confidence interval (CI) 1.066–1.552, P = 0.009]. The results of the subgroup analysis showed that Crohn’s disease (ORIVW = 1.218, 95% CI 1.030–1.441, P = 0.021) rather than ulcerative colitis (ORIVW = 1.206, 95% CI 0.984–1.478, P = 0.072) had a causal effect on DLBCL. No horizontal and directional pleiotropy was observed in the MR studies.

Conclusions

The above MR study concluded that IBD itself is causally responsible for DLBCL, especially Crohn’s disease. Further investigations are needed to elucidate the mechanism underlying this direct causal link.