bluuebunny/crossref_metadata_2025 huggingface dataset:
MRI Image-Based Automatic Segmentation and Classification of Brain Tumor and Swelling Using Novel Methodologies
Authors: Mundada Kapil , Kulkarni Jayant
Published: March 2023

In the medical image analysis field, brain tumors (BTs) classification is a complicated process. For effortlessly detecting the tumor devoid of any surgical interference, the radiologists are aided with automated along with computerized technology. Currently, in the field of medical image processing along with analysis, admirable progress has been made by deep learning (DL) methodologies. In medical fields, for resolving several issues, huge attention was paid to DL techniques. For automation of several performed by radiologists like (1) lesion detection, (2) segmentation, (3) classification, (4) monitoring, along with (5) also prediction of treatment response that is not achievable without software, DL might be wielded. Nevertheless, classifying BTs by utilizing magnetic resonance imaging (MRI) has various complications like the difficulty of brain structure along with the intertwining of tissues in it; additionally, the brain’s higher density nature also makes the BT Classification (BTC) process quite complex. Therefore, by utilizing novel systems, MRI-centric Automatic segmentation together with classifications of BT and swelling have been proposed to overcome the aforementioned issues. The proposed methodology underwent various operations to detect BTs effectively. Initially, by utilizing the Range-centric Otsu’s Thresholding (ROT) algorithm, the skull stripping (SS) is conducted. After that, by performing contrast enhancement (CE) along with noise removal, the skull-stripped images are pre-processed. Next, by employing the Rectilinear Watershed Segmentation (RWS) algorithm, the tumor or swelling areas are segmented. Afterward, to obtain the precise tumor or swelling region, the morphological operations are executed on the segmented areas; subsequently, the desired along with relevant features are extracted. Lastly, the features being extracted are inputted to the classifier termed Uniform Convolution neural network (UCNN). The tumor tissues along with the swelling tissues are classified precisely in the classification phase. Here, the openly accessible BT Image Segmentation Benchmark (BRATS) datasets are utilized. Then, the outcomes obtained are analogized with prevailing methodologies. The experiential outcomes displayed that the BTC is performed by the proposed model with a higher accuracy rate; thus, outshined the other prevailing models.
HEMORHEOLOGICAL MODELS APPLIED TO DATA ANALYSIS IN GROUPS OF PATIENTS AND IN HEALTHY SUBJECTS
Authors: ANTONOVA N. , PASKOVA V. , VELCHEVA I. , ZVETKOVA E.
Published: March 2023

An overview of some mathematical models describing the rheological behavior of blood is done. Several known models were used to describe the non-Newtonian rheological properties of blood. The parameters of two of the simplest models — the power law and the Herschel–Bulkley law were used to analyze the differences between the microrheological and micromechanical characteristics of blood in a group of patients with diabetes mellitus type 2 (T2DM) and in healthy subjects. The experiments were carried out with Low Shear 30 (LS 30) Contraves viscometer in a wide range of shear rates. All experimental data were statistically processed using the Mann–Whitney U-test for intergroup comparison of independent variables, as well as the t-test. The Statistica program was used for statistical processing. The results obtained are compared with the hemorheological models from other disease states.
Impact of Dielectric Conductivity and Other Process Parameters on Machining Characteristics in WEDM of Al 6065 Alloy
Authors: Mandal Kingshuk , Sekh Mukandar , Bose Dipankar , Mitra Souren , Sarkar Soumya
Published: March 2023

Among the wire electrical discharge machining (WEDM) parameters, dielectric conductivity plays a crucial role to determine the performance characteristics of the process. In this study, the effects of dielectric conductivity and four other significant process parameters such as pulse on time ([Formula: see text], arc on time ([Formula: see text], servo sensitivity ([Formula: see text], and open-circuit voltage ([Formula: see text] on Al 6065 have been investigated. Experimental result shows that maximum cutting speed is obtained at a 10 mho/m dielectric conductivity ([Formula: see text] setting. It is also found that for a broad range of corner error ([Formula: see text] and surface roughness ([Formula: see text] during single-pass cutting operations, 10[Formula: see text]mho/m conductivity settings give the best result. However, to achieve the corner accuracy and a surface finish lower than the critical limit (i.e., [Formula: see text][Formula: see text]mm & [Formula: see text]m), 4 mho/m conductivity is found to be the best setting. In this concern, a suitable optimization technique is used to prepare a technical guideline for the optimal machining of Al 6065. Additionally, heat-affected zone (HAZ) and surface topography analysis have been carried out to evaluate the characteristics of the WEDM surface. It is observed from the machined surface that the surface is full of discharge craters, micro-voids, and recast globules. On the other hand, HAZ decreases as the conductivity of the dielectric increases.
A note on traces of conformal twisted signature operators
Authors: Hao Meng , Wang Jian
Published: March 2023

In this paper, the traces of conformal twisted signature operators and noncommutative residue for compact manifolds with boundary are considered, the classic gravity representation for manifolds with boundary associated with conformal twisted signature operators and Kastler–Kalau–Walze-type theorems is explored.
Muscle contraction exercise for low back pain
Authors: Alarab Azzam , Shameh Ratib Abu , Ahmad Muntaser S.
Published: March 2023

Background: Low-back pain (LBP) continues to be one of the main problems for which sufferers seek treatment in primary care. It can be treated with different physiotherapy mechanisms.

Objective: The purpose of the study is to compare the effect of isotonic and isometric exercise on the reported pain of patients with low back pain.

Methods: Thirty participants, 16 males and 14 females aged between 22 and 50 years suffering from nonspecific low back pain were included. The sample was divided randomly into two groups, group A isometric exercises and group B isotonic exercises, both groups received conservative therapy of TENS and infrared (IR) therapy. The following outcome measures were used: Visual analogue scale, modified Oswestry disability index (MODI) and Endurance Test Measurement were administered pre-treatment and at the end of four weeks of treatment.

Results: Both groups were comparable in terms of demographic data, except for weight. Inter group analysis was done using the Mann–Whitney test. When comparing pre- and post-treatments using VAS scores, there were no significant differences between group A and group B (pre-test: [Formula: see text]; Post-test: [Formula: see text]). Mann–Whitney test was used to calculate the [Formula: see text]-value test between pre-treatment and post- treatment for MODI and there was no significant difference between group A and group B, where the pre-test [Formula: see text]-value was 0.061, and post-treatment was 0.077. Comparing between groups, pre- and post-abdominal endurance scores were done using the Mann–Whitney test. The pre-treatment scores revealed [Formula: see text] value of 0.345, and the post-treatment scores revealed [Formula: see text] value of 0.305. Therefore, there is no statistically significant difference between group A and group B in endurance scores.

Conclusion: There was no difference between the use isotonic and isometric exercises on LBP patients.
Malicious Software Detection based on URL-API Intensity Feature Selection Using Deep Spectral Neural Classification for Improving Host Security
Authors: Lavanya B. , Shanthi C.
Published: March 2023

In recent years, the internet of services has been more responsive to access through the development of various application program interfaces (API). Accessing an HTTP uniform resource locator (URL) contains malicious software intended by the attacker to create security breaches through the use of APIs from various services on the internet. By default, the non-attentive URL downloads and installs malware in the background without the user’s knowledge. The host does not analyze the API-URL security certificate contract due to the feature access by the user. Therefore, the current Machine Learning (ML) techniques only check malware signatures and certificates rather than analyzing URL behaviour based on the impact of a URL accessed from the internet. To address this problem, we propose a novel intelligent malicious software based on URL-API intensity feature selection (IFS) and deep spectral neural classification (DSNC) for improving Host Security. Initially, the URL — successive certificate signing (SCS) of the user link accessibility is verified based on API download rate logs. This system identifies the best malware software. The Link Redirection Stability Rate (LRSR) is estimated based on the Redirection URL by accessing the direct link and redirect link. The domain transformation matrix (DTM) was created to create a pattern to access successive features. URL-API Intensity Feature Selection selects each estimated feature, and the selected features are based on soft-max logical activation with a recurrent neural network (RNN) optimized for deep learning. RNN is trained in the spectral domain for improving computation and efficiency. It predicts the class based on the risk of malicious weight to categorize class by reference. The proposed IFS-DSNC achieves accuracy of 95.6% than the other algorithms such as KNN, NB, CNN, LCS, GCRNC AGSCR. The experimental result shows that the proposed method provides better performance in finding malware software than the existing approaches, thereby improving the security against host breaching.
Impact of Fear and Prey Refuge Parameters in a Fuzzy Prey–Predator Model with Group Defense
Authors: Das Soumya , Biswas Suvankar , Das Pritha
Published: March 2023

Prey–predator interactions are perhaps the most ordinarily noticed phenomena in the environment. In this article, we have proposed a three-species prey–predator model incorporating three important factors, namely, prey refuge, group defense, and the growth rate of two prey species which is reduced for the amount of fear of the predator species. All the biological parameters of our system have been presented as fuzzy numbers to make them more realistic. The system has been studied analytically and numerically in the fuzzy sense. Model analyses such as positivity, boundedness, and permanence of the system are investigated. Stability analysis at all equilibrium points of the system has been studied. Hopf bifurcation analysis around the positive interior equilibrium point has been discussed. All the numerical simulations of the system are presented with suitable tables and graphical diagrams by using MATHEMATICA and MATLAB. Numerically, we have seen that the fear effect and prey refuge parameter can stabilize the system from chaos to a stable region. The effect of fear and prey refuge on stability has been analyzed in the numerical section. Stable focus and limit cycle analysis are investigated in crisp as well as fuzzy environment. The system undergoes Hopf bifurcation at the positive equilibrium point when the fear parameter [Formula: see text] and refuge parameter [Formula: see text] cross the threshold value in crisp as well as fuzzy environment.
Decision-Making Algorithm of Rough Soft Γ-Semihypergroups and Associated Rough Soft Semihypergroups
Authors: Rakhsh Khorshid N. , Ostadhadi-Dehkordi S.
Published: March 2023

In this paper, we apply soft rough sets to the special algebraic hyperstructure and give the concepts of soft rough [Formula: see text]-semihypergroup, which is an extended definition of rough groups and we use the terminologies of [Formula: see text]-soft sets and [Formula: see text]-soft sets to research soft rough algebraic hyperstructures. We propose the notion of lower and upper approximations with respect to [Formula: see text]-semihypergroup and discuss some significant properties of them. Also, we consider a connection between upper(lower) approximation of [Formula: see text]-semihypergroups and upper(lower) approximation of associated semihypergroups. Moreover, we obtain the decision-making algorithm of rough soft [Formula: see text]-semihypergroups, then we find a relation between the decision-making algorithm of rough soft [Formula: see text]-semihypergroup and its associated rough soft semihypergroup.
Fuzzy Filters in Pseudo-CI-Algebras
Authors: Shojaei Neda , Borumand Saeid Arsham , Babaei Hojat
Published: March 2023

In this paper, the notion of fuzzy pseudo-CI-filter in a pseudo-CI-algebra is introduced and its elementary properties are investigated. With the upper level set, the relationship between pseudo-CI-filter and fuzzy pseudo-CI-filter is shown and this relationship is illustrated with an example. Some type of fuzzy pseudo-CI-filters and the relationships between them and the fuzzy pseudo-CI-filter are checked. We study generated fuzzy pseudo-CI-filter by a fuzzy set. In addition, the properties of fuzzy pseudo-CI-filter are studied in Noetherian and Artinian pseudo-CI-algebra. We construct a fuzzy pseudo-CI-filter by a strictly ascending sequence of pseudo-CI-filter of pseudo-CI-algebra and any strictly decreasing sequence in [Formula: see text].
Effect of random movement and cooperative hunting in the prey–predator system: A dynamical approach
Authors: Shivam  , Singh Teekam , Kumar Mukesh
Published: March 2023

Self-diffusion prerequisite is obtained as the spreading approach of biological populations. Cooperative hunting is a common behavior in predator populations that promotes predation and the coexistence of the prey–predator system. On the other side, the Allee effect among prey may cause the system to become unstable. In this paper, a diffusive prey–predator system with cooperative hunting and the weak Allee effect in prey populations is discussed. The linear stability and Hopf-bifurcation analysis had been used to examine the system’s stability. From the spatial stability of the system, the conditions for Turing instability have been derived. The multiple-scale analysis has been used to derive the amplitude equations of the system. The stability analysis of these amplitude equations leads to the formation of Turing patterns. Finally, numerical simulations are used to analyze spatial patterns forming in 1-D and 2-D. The studies indicate that the model can generate a complex pattern structure and that self-diffusion has a drastic impact on species distribution.
Bifurcation analysis of an SIS epidemic model with a generalized non-monotonic and saturated incidence rate
Authors: Huang Chunxian , Jiang Zhenkun , Huang Xiaojun , Zhou Xiaoliang
Published: March 2023

In this paper, a new generalized non-monotonic and saturated incidence rate was introduced into a susceptible-infected-susceptible (SIS) epidemic model to account for inhibitory effect and crowding effect. The dynamic properties of the model were studied by qualitative theory and bifurcation theory. It is shown that when the influence of psychological factors is large, the model has only disease-free equilibrium point, and this disease-free equilibrium point is globally asymptotically stable; when the influence of psychological factors is small, for some parameter conditions, the model has a unique endemic equilibrium point, which is a cusp point of co-dimension two, and for other parameter conditions the model has two endemic equilibrium points, one of which could be weak focus or center. In addition, the results of the model undergoing saddle-node bifurcation, Hopf bifurcation and Bogdanov–Takens bifurcation as the parameters vary were also proved. These results shed light on the impact of psychological behavior of susceptible people on the disease transmission.
High Curie Temperature in Epitaxial D022–Mn3−xGa Ultrathin Films
Authors: Gutiérrez-Pérez Rocío M. , Antón Ricardo López , Holguín-Momaca José T. , Olive-Méndez Sion F.
Published: March 2023

The D0[Formula: see text]–Mn3Ga ferrimagnet promises potential applications in spintronics due to its low magnetization, strong perpendicular magnetic anisotropy and high Curie temperature. In the form of thin and thick films, these properties are preserved. Here, we report on the structural and magnetic characterization of epitaxial D0[Formula: see text]–Mn[Formula: see text]Ga ultrathin films with thicknesses of 2[Formula: see text]nm, 5[Formula: see text]nm and 8[Formula: see text]nm grown on Cr buffer layers by magnetron sputtering. We found that the films are perfect single crystals with flat surfaces and Curie temperatures higher than 300[Formula: see text]K. The 2[Formula: see text]nm-thick ultrathin film has higher magnetization than that of the thicker films, likely due to uncompensated ferrimagnetic planes, along the c-axis, linked to the surface roughness at the atomic scale. These properties highly suit the requirements for the elaboration of spintronic devices such as magnetic tunnel junctions.
Slow Development of a Day 5 Fresh Transferred Embryo Leads to Reduced Live Birth Rate but Not Birthweight: A Multicenter Retrospective Cohort Study
Authors: Watson Kate , Ong Kee , Korman Irving , Turner Ross , Shaker David , Mokrzecki Steve , Vollenhoven Beverley , Zander-Fox Deirdre , Liu Yanhe
Published: March 2023

Objective: This study aims to investigate the impact of slow embryo development on the subsequent live birth rate and birthweight outcomes following a fresh day 5 transfer.

Study design: This retrospective multicenter cohort study included 1,213 consecutive patients undergoing autologous oocyte in vitro fertilization (IVF) treatment at four associated private clinics during 2016–2019. Only fresh single day 5 transfers were included for analysis.

Results: No implantation was achieved by embryos that failed to reach the early blastocyst stage on day 5 ([Formula: see text]). After adjusting for potential confounding factors, multivariate logistic regression (expressed as adjusted odds ratio or aOR and [Formula: see text] confidence interval) showed a significantly reduced live birth rate in early blastocysts ([Formula: see text]) in reference to those at the expanding (aOR = 0.584, [Formula: see text], [Formula: see text], [Formula: see text]), expanded (aOR = 0.322, [Formula: see text], [Formula: see text], [Formula: see text]), or hatching/hatched stages (aOR = 0.255, [Formula: see text], [Formula: see text], [Formula: see text]). However, early blastocysts led to similar birthweights ([Formula: see text], [Formula: see text]) in comparison to those at the expanding ([Formula: see text], [Formula: see text], [Formula: see text]), expanded ([Formula: see text], [Formula: see text], [Formula: see text]), or hatching/hatched stages ([Formula: see text], [Formula: see text], [Formula: see text]). This was further confirmed by linear regression analysis using either birthweight or [Formula: see text] score (gestation-adjusted birthweight).

Conclusion: Slow day 5 development is associated with reduced live birth rate when transferred fresh, however, subsequent birthweight is not impacted once pregnancy is initiated.
The Cuesta de Rahue Basement Inlier (Southern Neuquén Precordillera, Argentina): a Devonian to Triassic polyphase orogenic record in northern Patagonia
Authors: Oriolo Sebastián , González Pablo D. , Alegre Pablo , Wemmer Klaus , Varela Ricardo , Basei Miguel A. S.
Published: March 2023

We present new geological, structural and microstructural data, together with K–Ar biotite and illite geochronological data, for the igneous–metamorphic rocks exposed in the Cuesta de Rahue Basement Inlier in the Southern Neuquén Precordillera, Argentina. We use these data to reconstruct the Late Paleozoic to Mesozoic tectonometamorphic and magmatic history of northwestern Patagonia. This block consists of a medium-grade metasedimentary sequence (the Cuesta de Rahue Metamorphic Complex), Late Carboniferous granitoids and a low-grade metavolcano-sedimentary unit (the Arroyo Coloco Metamorphic Complex). The Cuesta de Rahue Metamorphic Complex was deposited during the mid-Paleozoic and underwent Devonian low-pressure regional metamorphism, followed by the intrusion of granitoids at
c.
300 Ma. By contrast, the Arroyo Coloco Metamorphic Complex records deformation and metamorphism under epizonal conditions (>300°C), constrained at
c.
232–199 Ma by K–Ar and X-ray diffraction illite data. The Cuesta de Rahue Basement Inlier thus records a protracted orogenic evolution, recording Devonian metamorphism, Late Carboniferous–Permian Gondwanide tectonomagmatic processes, and Late Triassic deformation and metamorphism. This block was later affected by Mesozoic normal faulting and Miocene–Pliocene Andean deformation. The Andean deformation was intimately related to the reactivation of inherited basement fabrics, favouring a transpressional deformation regime.

Supplementary material:
Supplementary Material 1 – Analytical procedures is available at
https://doi.org/10.6084/m9.figshare.c.6484467
Teaching with QR Codes: Accessible Technology for the Novice Educator
Authors: Schulz Elizabeth V , Ottolini Katherine M
Published: March 2023

Quick response (QR) codes allow for quick and easy accessibility of just-in-time training (JiTT) for a variety of online materials. They are becoming more widely utilized to share educational materials, with potential vast applications for health professions education. In this article, we describe the development of a novel video-based equipment skills training curriculum incorporating QR codes and discuss the broader implications for educators.
Neural Control of Sexually Dimorphic Social Behavior: Connecting Development to Adulthood
Authors: McCarthy Margaret M.
Published: March 2023

Rapid advances in the neural control of social behavior highlight the role of interconnected nodes engaged in differential information processing to generate behavior. Many innate social behaviors are essential to reproductive fitness and therefore fundamentally different in males and females. Programming these differences occurs early in development in mammals, following gonadal differentiation and copious androgen production by the fetal testis during a critical period. Early-life programming of social behavior and its adult manifestation are separate but yoked processes, yet how they are linked is unknown. This review seeks to highlight that gap by identifying four core mechanisms (epigenetics, cell death, circuit formation, and adult hormonal modulation) that could connect developmental changes to the adult behaviors of mating and aggression. We further propose that a unique social behavior, adolescent play, bridges the preweaning to the postpubertal brain by engaging the same neural networks underpinning adult reproductive and aggressive behaviors.
Expanding Notions of LGBTQ+
Authors: Russell Stephen T. , Bishop Meg D. , Fish Jessica N.
Published: March 2023

Sexual identity labels and meanings have been expanding. We explore how sexual identities are taking shape, intertwining, and emerging in new forms among a growing number of LGBTQ+ people (i.e., lesbian, gay, bisexual, transgender, queer, and questioning, or people whose identities are outside the historically privileged or dominant groups of heterosexual sexual identities). We situate contemporary sexual identities in theories of the social construction of identity, intersectionality, and the life course. We review recent research that illuminates identity complexity and intersectionality, the increasingly intertwined understandings and experiences of sexuality and gender, and intersections of sexuality and gender with identities embedded in race and social class. Finally, we consider new work that situates sexual identities in the context of life course development, including life stage, developmental processes, and relationships.
Neighborhood–School Structures: A New Approach to the Joint Study of Social Contexts
Authors: Rich Peter , Owens Ann
Published: March 2023

Robust literatures separately estimate school effects and neighborhood effects on children's educational, economic, health, and other outcomes that measure well-being. A growing body of research acknowledges that both contexts matter and considers neighborhoods and schools jointly. In this review, we synthesize the array of results that emerge from these studies and critique the tendency for researchers to evaluate which matters more, neighborhoods versus schools. We propose a reorientation of this scholarship that incorporates research on neighborhood and school selection and segregation processes. We argue that contextual effects research would be enriched by considering local neighborhood–school structures: the ways that families choose neighborhoods and schools and that neighborhoods and schools mutually and cyclically constitute one another. We conclude with recommendations for bringing neighborhood–school structures to bear on both outcomes-oriented studies of neighborhood and school effects as well as studies of contextual selection and segregation.
Looking at Patent Law: Patenting an Iron Slurry Electrode Redox Flow Battery-A Case Study
Authors: Jennings Taylor E. , Inman Maria
Published: March 2023

In this installment of the “Looking at Patent Law” series, we present a case study of the prosecution events of U.S. Patent No. 9,559,375 directed towards “Iron Flow Battery”. This invention aligns with several divisions of the Electrochemical Society (ECS), including Industrial Electrochemistry and Electrochemical Engineering (IE&EE), Battery (BATT), Energy Technology (ETD) and Electrodeposition (ELDP). The case study begins with a brief synopsis of the background of the invention followed by 1) summary of key drawings and the specification of the invention, 2) inventor assignment and power of attorney designations, 3) submission of the Invention Disclosure Statement (IDS) and associated Duty of Candor, 4) summary of the non-final office action (NF-OA) and rejection, and 5) applicant response and allowance of the patent application. The case study illustrates overcoming lack of “novelty” and “obviousness” rejections by combining the limitation of dependent claims with the independent claim. With this case study, we hope to de-mystify the patent prosecution process and better prepare electrochemical and solid-state scientists, engineers and technologists to interact with their patent counsel regarding their inventions.
Investigation on the Processing Quality of Nanosecond Laser Stealth Dicing for 4H-SiC Wafer
Authors: Song Qi , Zhang Zhe , Xu Ziye , Wen Zhidong , Shi Haiyan , Zhang Kunpeng , Li Man , Zhang Zichen , Hou Yu , Song Zhengxun
Published: March 2023

Silicon carbide (SiC), due to its characteristic materials performance, gets more attention in Radio Frequecy (RC) and High-power device fabrication. However, SiC wafer dicing has been a tricky task because of the high hardness and brittleness. The blade dicing suffers from poor efficiency and debris contaminants. Furthermore, the laser ablation dicing and Thermal Laser Separation (TSL) can have thermal damage and irregular crack propagation. In this study, Stealth Dicing (SD) with nanosecond pulse laser method was applied to 4H-SiC wafer. A series of experiments were conducted to analyze the influences of different parameters on cross section and surface. An edge defect less than 3 μm and cross section with roughness of about 0.8 μm was achieved. And the three-point stress test was applied to obtain the die strength. Besides, a novel method of double pulse inducing cracks growth was proposed for the first time to optimize the surface edge. Finite Element Analysis (FEA) verifed the feasibility. Through experiments, the edge defect decreased to less than 2 μm. This work contributes to the wafer Stealth Dicing application for SiC and advance semiconductor materials.
[Retracted] Research on Localization Parameter Estimation and Algorithm in the Digital Television Terrestrial Broadcasting
Authors: Bao Songjian , Yang Shouliang , Ou Hanwen , Song Jing
Published: March 2023

This paper mainly studies the positioning based on time of arrival and time difference of arrival. The quantity to be obtained is mainly time. Time of arrival measurement value can be obtained directly through symbolic timing synchronization, and its effective information can be obtained at the same time. Symbolic timing synchronization in digital video broadcast‐terrestrial system can be divided into two stages: rough estimation and fine estimation. Rough estimation is based on the maximum likelihood estimation algorithm. The main purpose of rough estimation is to estimate the starting position of orthogonal frequency division multiplexing symbols, so that the starting position falls within the cyclic prefix of orthogonal frequency division multiplexing symbols. The purpose of fine estimation is to determine exactly the starting position of the orthogonal frequency division multiplexing symbol. In this paper, the symbolic timing synchronization algorithm of digital video broadcast‐terrestrial system is studied and analyzed, and simulation is carried out for different channel models. Simulation results show that the synchronization algorithm achieves the best performance in additive white Gaussian noise channel and has good estimation performance in slow fading Rayleigh channel.
Circulating IGFBP-3 and Interleukin 6 as Predictors of Osteoporosis in Postmenopausal Women: A Cross-Sectional Study
Authors: Shi Xiu , Jiang Jingjing , Hong Ru , Xu Feng , Dai Shouqian
Published: March 2023

Objective. To explore the relationship between circulating IGFBP-3, IL-6, and bone mineral density and the potential diagnostic role of circulating IGFBP-3 and IL-6 in postmenopausal women with osteoporosis. Methods. Eighty-five postmenopausal women at Soochow University’s First Affiliated Hospital, Osteoporosis and Menopause Clinics, were recruited. Forty-five of 85 women were diagnosed with osteoporosis. Circulating IL-6, PTH, 1,25(OH)2D3, osteocalcin (OST), IGF-1, IGFBP-3, and bone mineral density (BMD) of the lumbar spine (LS) and femoral neck (FN) were measured in 40 ordinary and 45 osteoporotic women. A simple regression analysis calculated the correlation between age, BMD, IL-6, and IGFBP-3. Multiple stepwise regression analyses were conducted to determine which variables were independently related to BMD. The potential role of IGFBP-3 and IL-6 in the diagnosis of postmenopausal osteoporosis was predicted using the area under the receiver operating characteristic curve (ROC, AUC). Results. Age, years since menopause, and circulating IL-6, PTH, and IGFBP-3 were significantly higher in the osteoporosis group compared to the normal group. Osteoporotic women had substantially lower BMDs of the LS and FN than normal women. Age-related increases were found for IGFBP-3 and IL-6, whereas age-related decreases were observed for LS/FN BMD. IGFBP-3 and IL-6 were both negatively correlated with LS and FN BMD. Stepwise multiple regression analysis showed that IGFBP-3 and IL-6 were strong predictors of BMD in postmenopausal women. AUC cut-off values (IGFBP-3: 3.65, IL-6: 0.205) were best evaluated for the diagnosis of postmenopausal women with osteoporosis, and the AUC for circulating IGFBP-3 and IL-6 were 0.706 (95% CI 0.594–0.818) and 0.685 (95% CI 0.571–0.798), respectively. Conclusion. In this cross-sectional study of postmenopausal women, IGFBP-3 and IL-6 were negatively related to BMD. Circulating IGFBP-3 and IL-6 might be essential predictors of postmenopausal osteoporosis and can help predict osteoporotic fracture.
Thermal Adsorption and Corrosion Characteristic Study of Copper Hybrid Nanocomposite Synthesized by Powder Metallurgy Route
Authors: Senthilkumar V. , Nagadeepan A. , De Poures Melvin Victor , Sasikumar R. , Mukilarasan N. , Aruna M. , Priya C. B. , Kaliyaperumal Gopal , Ramaraj Elangomathavan
Published: March 2023

Novel constitutions of ceramic bond the new opportunity of engineering materials via solid-state process attaining enhanced material characteristics to overcome the drawback of conventional materials used in aquatic applications. The copper-based materials have great potential to explore high corrosion resistance and good thermal performance in the above applications. The main objectives of this research are to develop and enhance the characteristics of the copper-based hybrid nanocomposite containing different weight percentages of alumina and graphite hard ceramics synthesized via solid-state processing (powder metallurgy). The presence of alumina nanoparticles with a good blending process has to improve the corrosion resistance, and graphite nanoparticles may limit the weight loss of the sample during potentiodynamic corrosion analysis. The developed composite’s micro Vickers hardness is evaluated by the E384 standard on ASTM value of 69 Hv and is noted by increasing the weight percentages of alumina nanoparticles. The conduction temperature of actual sintering anticipates the thermogravimetric analysis of developed composite samples varied from 400°C to 750°C. The thermogravimetric graph illustration curve of the tested sample found double-step decomposition identified between 427°C and 456°C. The potentiodynamic analyzer is used to evaluate the corrosion behaviour of the sample and the weight loss equation adopted for finding the theoretical weight loss of the composite.
Assessment of Constraints of Artificial Insemination Service in Smallholder Dairy Cattle Keepers in Kacha Bira District of Southern Ethiopia
Authors: Mathewos Mesfin , Endale Habtamu , Tesfahun Mulugeta , Tiele Dembelo , Bukero Remedan
Published: March 2023

Artificial insemination (AI) is among the most effective reproductive biotechnologies that afford widespread propagation of genes carried by superior males. A cross‐sectional study followed by a simple random sampling technique was conducted from December 2021 to May 2022 to assess the constraints of artificial insemination (AI) provision in and around Kacha Bira district, Southern Ethiopia, using a structured questionnaire. A total of 200 respondents were surveyed accordingly. In this study, the education level of farmers revealed no statistically significant difference (P > 0.05) with the identification of time of insemination. Conception failure (62.5%), unavailability of artificial insemination technicians (7.5%), dystocia (3.5%), and both conception failure and unavailability of artificial insemination technicians (4.5%) were found to be the major constraints of AI service in the study area according to dairy cattle owners’ response and revealed a statistically significant difference (P < 0.05) with AI service. Although statistically significant (P < 0.05), differences in AI service interruptions during both regular working hours and weekends and holidays were also observed. Among total respondents, 20.5% of dairy cattle owners got AI service at right time, but 79.5% of them used it at the wrong time. Regarding inbreeding problems, 77.5% of dairy cattle owners responded that there was no inbreeding problem and the remaining 22.5% of farmers indicated presence of inbreeding problem of which 10.5% and 10% had a perception that local breeds had low milk production and low genetic improvement than exotic breeds, respectively. On the other hand, 11.5% of dairy cattle owners responded that local breeds have a similar level of disease resistance to that of exotic breeds (11%). 48.5% of dairy farmers reported that bellowing is the most frequent sign that they used to detect heat followed by vulval discharge (23%) and mounting on other cows (10%). Majority (78.5%) of the dairy cattle owners interviewed were found to be not satisfied with the artificial insemination services. In general, different AI technicians and cattle and dairy cattle keeper‐related factors constrain the AI service and its result in survey site. Therefore, smallholder dairy cattle owners should be trained sufficiently about the AI service strategies, usage, and proper management of dairy farms and the technical constraints should be avoided in order to provide AI service sufficiently.
BMSC-Derived Exosomes Alleviate Sepsis-Associated Acute Respiratory Distress Syndrome by Activating the Nrf2 Pathway to Reverse Mitochondrial Dysfunction
Authors: Li Zhenzhen , Zheng Beijie , Liu Chenchen , Zhao Xiang , Zhao Yupeng , Wang Xiangrui , Hou Lei , Yang Zhongwei
Published: March 2023

Type II alveolar epithelial cell (AECII) apoptosis is one of the most vital causes of sepsis-induced acute respiratory distress syndrome (ARDS). Recent evidence has proved that bone mesenchymal stem cell-derived exosomes (BMSC-exos) can effectively reduce sepsis-induced ARDS. However, the function and molecular mechanism of BMSC-exos in sepsis-induced AECII apoptosis remain to be elucidated. In the present study, a more significant number of AECII apoptosis, high mitochondrial fission p-Drp1 protein levels, and low levels of mitochondrial biogenesis-related PGC1α, Tfam, and Nrf1 proteins accompanied with ATP content depression were confirmed in AECIIs in response to sepsis. Surprisingly, BMSC-exos successfully recovered mitochondrial biogenesis, including the upregulated expression of PGC1α, Tfam, Nrf1 proteins, and ATP contents, and prohibited p-Drp1-mediated mitochondrial fission by promoting Nrf2 expression. However, the aforementioned BMSC-exo reversal of mitochondrial dysfunction in AECIIs can be blocked by Nrf2 inhibitor ML385. Finally, BMSC-exos ameliorated the mortality rate, AECII apoptosis, inflammatory cytokine storm including HMGB1 and IL-6, and pathological lung damage in sepsis mice, which also could be prevented by ML385. These findings reveal a new mechanism of BMSC-exos in reversing mitochondrial dysfunction to alleviate AECII apoptosis, which may provide novel strategies for preventing and treating sepsis-induced ARDS.
Supplementary Figure 2 from Mitochondrially Targeted p53 Has Tumor Suppressor Activities In vivo
Authors: Talos Flaminia , Petrenko Oleksi , Mena Patricio , Moll Ute M.
Published: March 2023

Supplementary Figure 2 from Mitochondrially Targeted p53 Has Tumor Suppressor Activities In vivo
Supplementary Figure 1 from Nitric Oxide Boosts Chemoimmunotherapy via Inhibition of Acid Sphingomyelinase in a Mouse Model of Melanoma
Authors: Perrotta Cristiana , Bizzozero Laura , Falcone Sestina , Rovere-Querini Patrizia , Prinetti Alessandro , Schuchman Edward H. , Sonnino Sandro , Manfredi Angelo A. , Clementi Emilio
Published: March 2023

Supplementary Figure 1 from Nitric Oxide Boosts Chemoimmunotherapy via Inhibition of Acid Sphingomyelinase in a Mouse Model of Melanoma
Supplementary Figures 1-2 from Chimeric NKG2D Receptor–Bearing T Cells as Immunotherapy for Ovarian Cancer
Authors: Barber Amorette , Zhang Tong , DeMars Leslie R. , Conejo-Garcia Jose , Roby Katherine F. , Sentman Charles L.
Published: March 2023

Supplementary Figures 1-2 from Chimeric NKG2D Receptor–Bearing T Cells as Immunotherapy for Ovarian Cancer
Supplementary Figure 4 from A Placenta-Specific Gene Ectopically Activated in Many Human Cancers Is Essentially Involved in Malignant Cell Processes
Authors: Koslowski Michael , Sahin Ugur , Mitnacht-Kraus Rita , Seitz Gerhard , Huber Christoph , Türeci Özlem
Published: March 2023

Supplementary Figure 4 from A Placenta-Specific Gene Ectopically Activated in Many Human Cancers Is Essentially Involved in Malignant Cell Processes
Supplementary Figure 1 from RING Domain–Mediated Interaction Is a Requirement for MDM2's E3 Ligase Activity
Authors: Kawai Hidehiko , Lopez-Pajares Vanessa , Kim Mihee M. , Wiederschain Dmitri , Yuan Zhi-Min
Published: March 2023

Supplementary Figure 1 from RING Domain–Mediated Interaction Is a Requirement for MDM2's E3 Ligase Activity
Supplementary Figure 2 from Caveolin-1 Reduces Osteosarcoma Metastases by Inhibiting c-Src Activity and Met Signaling
Authors: Cantiani Lara , Manara Maria Cristina , Zucchini Cinzia , De Sanctis Paola , Zuntini Monia , Valvassori Luisa , Serra Massimo , Olivero Martina , Di Renzo Maria Flavia , Colombo Mario Paolo , Picci Piero , Scotlandi Katia
Published: March 2023

Supplementary Figure 2 from Caveolin-1 Reduces Osteosarcoma Metastases by Inhibiting c-Src Activity and Met Signaling
Supplementary Figure Legends 1-4 from Hypoxia and Hypoxia-Inducible Factor-1 Expression Enhance Osteolytic Bone Metastases of Breast Cancer
Authors: Hiraga Toru , Kizaka-Kondoh Shinae , Hirota Kiichi , Hiraoka Masahiro , Yoneda Toshiyuki
Published: March 2023

Supplementary Figure Legends 1-4 from Hypoxia and Hypoxia-Inducible Factor-1 Expression Enhance Osteolytic Bone Metastases of Breast Cancer
Supplementary Figure 1 from Caveolin-1 Reduces Osteosarcoma Metastases by Inhibiting c-Src Activity and Met Signaling
Authors: Cantiani Lara , Manara Maria Cristina , Zucchini Cinzia , De Sanctis Paola , Zuntini Monia , Valvassori Luisa , Serra Massimo , Olivero Martina , Di Renzo Maria Flavia , Colombo Mario Paolo , Picci Piero , Scotlandi Katia
Published: March 2023

Supplementary Figure 1 from Caveolin-1 Reduces Osteosarcoma Metastases by Inhibiting c-Src Activity and Met Signaling
Supplementary Table 1 from Ikaros Modulates Cholesterol Uptake: A Link between Tumor Suppression and Differentiation
Authors: Loeper Siobhan , Asa Sylvia L. , Ezzat Shereen
Published: March 2023

Supplementary Table 1 from Ikaros Modulates Cholesterol Uptake: A Link between Tumor Suppression and Differentiation
Supplementary Figure 1 from The Nuclear Receptor Coactivator Amplified in Breast Cancer-1 Is Required for Neu (ErbB2/HER2) Activation, Signaling, and Mammary Tumorigenesis in Mice
Authors: Fereshteh Mark P. , Tilli Maddalena T. , Kim Sung Eun , Xu Jianming , O'Malley Bert W. , Wellstein Anton , Furth Priscilla A. , Riegel Anna T.
Published: March 2023

Supplementary Figure 1 from The Nuclear Receptor Coactivator Amplified in Breast Cancer-1 Is Required for Neu (ErbB2/HER2) Activation, Signaling, and Mammary Tumorigenesis in Mice
Supplementary Figure 3 from Discovery of Epigenetically Silenced Genes by Methylated DNA Immunoprecipitation in Colon Cancer Cells
Authors: Jacinto Filipe V. , Ballestar Esteban , Ropero Santiago , Esteller Manel
Published: March 2023

Supplementary Figure 3 from Discovery of Epigenetically Silenced Genes by Methylated DNA Immunoprecipitation in Colon Cancer Cells
Supplementary Table 1 from Knock-in of Oncogenic Kras Does Not Transform Mouse Somatic Cells But Triggers a Transcriptional Response that Classifies Human Cancers
Authors: Arena Sabrina , Isella Claudio , Martini Miriam , de Marco Ario , Medico Enzo , Bardelli Alberto
Published: March 2023

Supplementary Table 1 from Knock-in of Oncogenic Kras Does Not Transform Mouse Somatic Cells But Triggers a Transcriptional Response that Classifies Human Cancers
Supplementary Figures 1-4 from Oncogenic BARD1 Isoforms Expressed in Gynecological Cancers
Authors: Li Lin , Ryser Stephan , Dizin Eva , Pils Dietmar , Krainer Michael , Jefford Charles Edward , Bertoni Francesco , Zeillinger Robert , Irminger-Finger Irmgard
Published: March 2023

Supplementary Figures 1-4 from Oncogenic BARD1 Isoforms Expressed in Gynecological Cancers
Supplementary Figure 1 from Epithelial to Mesenchymal Transition in Human Breast Epithelial Cells Transformed by 17β-Estradiol
Authors: Huang Yong , Fernandez Sandra V. , Goodwin Shirlean , Russo Patricia A. , Russo Irma H. , Sutter Thomas R. , Russo Jose
Published: March 2023

Supplementary Figure 1 from Epithelial to Mesenchymal Transition in Human Breast Epithelial Cells Transformed by 17β-Estradiol
Supplementary Figures 1-3 from Sigma-1 Receptors Bind Cholesterol and Remodel Lipid Rafts in Breast Cancer Cell Lines
Authors: Palmer Christopher P. , Mahen Robert , Schnell Eva , Djamgoz Mustafa B.A. , Aydar Ebru
Published: March 2023

Supplementary Figures 1-3 from Sigma-1 Receptors Bind Cholesterol and Remodel Lipid Rafts in Breast Cancer Cell Lines
Supplementary Data 3 from CD133+ and CD133− Glioblastoma-Derived Cancer Stem Cells Show Differential Growth Characteristics and Molecular Profiles
Authors: Beier Dagmar , Hau Peter , Proescholdt Martin , Lohmeier Annette , Wischhusen Jörg , Oefner Peter J. , Aigner Ludwig , Brawanski Alexander , Bogdahn Ulrich , Beier Christoph P.
Published: March 2023

Supplementary Data 3 from CD133+ and CD133− Glioblastoma-Derived Cancer Stem Cells Show Differential Growth Characteristics and Molecular Profiles
Supplementary Figure 1 from Gain of Oncogenic Function of p53 Mutants Induces Invasive Phenotypes in Human Breast Cancer Cells by Silencing CCN5/WISP-2
Authors: Dhar Gopal , Banerjee Snigdha , Dhar Kakali , Tawfik Ossama , Mayo Matthew S. , VanVeldhuizen Peter J. , Banerjee Sushanta K.
Published: March 2023

Supplementary Figure 1 from Gain of Oncogenic Function of p53 Mutants Induces Invasive Phenotypes in Human Breast Cancer Cells by Silencing CCN5/WISP-2
Supplementary Data 2 from CD133+ and CD133− Glioblastoma-Derived Cancer Stem Cells Show Differential Growth Characteristics and Molecular Profiles
Authors: Beier Dagmar , Hau Peter , Proescholdt Martin , Lohmeier Annette , Wischhusen Jörg , Oefner Peter J. , Aigner Ludwig , Brawanski Alexander , Bogdahn Ulrich , Beier Christoph P.
Published: March 2023

Supplementary Data 2 from CD133+ and CD133− Glioblastoma-Derived Cancer Stem Cells Show Differential Growth Characteristics and Molecular Profiles
Supplementary Figure 1 from Drug Sensitivity Prediction by CpG Island Methylation Profile in the NCI-60 Cancer Cell Line Panel
Authors: Shen Lanlan , Kondo Yutaka , Ahmed Saira , Boumber Yanis , Konishi Kazuo , Guo Yi , Chen Xinli , Vilaythong Jill N. , Issa Jean-Pierre J.
Published: March 2023

Supplementary Figure 1 from Drug Sensitivity Prediction by CpG Island Methylation Profile in the NCI-60 Cancer Cell Line Panel
Supplementary Table 4 from Overexpression of N-Myc Rapidly Causes Acute Myeloid Leukemia in Mice
Authors: Kawagoe Hiroyuki , Kandilci Ayten , Kranenburg Tanya A. , Grosveld Gerard C.
Published: March 2023

Supplementary Table 4 from Overexpression of N-Myc Rapidly Causes Acute Myeloid Leukemia in Mice
Supplementary Figure 2 from Silibinin Sensitizes Human Glioma Cells to TRAIL-Mediated Apoptosis via DR5 Up-regulation and Down-regulation of c-FLIP and Survivin
Authors: Son Yong-gyu , Kim Eun Hee , Kim Jin Yeop , Kim Seung U. , Kwon Taeg Kyu , Yoon A-Rum , Yun Chae-Ok , Choi Kyeong Sook
Published: March 2023

Supplementary Figure 2 from Silibinin Sensitizes Human Glioma Cells to TRAIL-Mediated Apoptosis via DR5 Up-regulation and Down-regulation of c-FLIP and Survivin
Supplementary Materials from Integrated Profiling of Basal and Luminal Breast Cancers
Authors: Adélaïde José , Finetti Pascal , Bekhouche Ismahane , Repellini Laetitia , Geneix Jeannine , Sircoulomb Fabrice , Charafe-Jauffret Emmanuelle , Cervera Nathalie , Desplans Jérôme , Parzy Daniel , Schoenmakers Eric , Viens Patrice , Jacquemier Jocelyne , Birnbaum Daniel , Bertucci François , Chaffanet Max
Published: March 2023

Supplementary Materials from Integrated Profiling of Basal and Luminal Breast Cancers
Supplementary Figure 3 from Fhit-Deficient Hematopoietic Stem Cells Survive Hydroquinone Exposure Carrying Precancerous Changes
Authors: Ishii Hideshi , Mimori Koshi , Ishikawa Kazuhiro , Okumura Hiroshi , Pichiorri Flavia , Druck Teresa , Inoue Hiroshi , Vecchione Andrea , Saito Toshiyuki , Mori Masaki , Huebner Kay
Published: March 2023

Supplementary Figure 3 from Fhit-Deficient Hematopoietic Stem Cells Survive Hydroquinone Exposure Carrying Precancerous Changes
Supplementary Figure 1 from Fhit-Deficient Hematopoietic Stem Cells Survive Hydroquinone Exposure Carrying Precancerous Changes
Authors: Ishii Hideshi , Mimori Koshi , Ishikawa Kazuhiro , Okumura Hiroshi , Pichiorri Flavia , Druck Teresa , Inoue Hiroshi , Vecchione Andrea , Saito Toshiyuki , Mori Masaki , Huebner Kay
Published: March 2023

Supplementary Figure 1 from Fhit-Deficient Hematopoietic Stem Cells Survive Hydroquinone Exposure Carrying Precancerous Changes