bluuebunny/crossref_metadata_2025 huggingface dataset:
The Role of Direct Oral Anticoagulants in Cancer-Associated Thrombosis According to the Current Literature
Authors: Nana Petroula , Dakis Konstantinos , Peroulis Michail , Rousas Nikos , Spanos Konstantinos , Kouvelos George , Arnaoutoglou Eleni , Matsagkas Miltos
Published: September 2021

Venous thromboembolism (VTE) is a common complication among patients suffering from malignancies, leading to an increased mortality rate. Novel randomized trials have added valuable information regarding cancer-associated thrombosis (CAT) management using direct oral anticoagulants (DOACs). The aim of this study is to present an overview of the current literature and recommendations in CAT treatment. A few randomized control trials (RCTs) have been integrated suggesting that DOACs may be effectively applied in CAT patients compared to low molecular weight heparins (LMWHs) with a decreased mortality and VTE recurrence rate. However, the risk of bleeding is higher, especially in patients with gastrointestinal malignancies. Real-world data are in accordance with these RCT findings, while in the currently available recommendations, DOACs are suggested as a reliable alternative to LMWH during the initial, long-term, and extended phase of treatment. Data retrieved from the current literature, including RCTs and “real-world” studies, aim to clarify the role of DOACs in CAT management, by highlighting their benefits and remarking upon the potential adverse outcomes. Current recommendations suggest the use of DOACs in well-selected patients with an increasing level of evidence through years.
Kinetics of Plastic Deformation Localization Bands in Polycrystalline Nickel
Authors: Barannikova Svetlana A. , Nadezhkin Mikhail V.
Published: September 2021

Jerky flow has recently aroused interest as an example of complex spatiotemporal dynamics resulting from the collective behavior of defects in Al- and Mg-based alloys under loading. This paper presents the results of the study of the macroscopic strain localization kinetics in Nickel 200 (99.5 wt % purity). Uniaxial tension of flat samples is monitored at room temperature in the load–unload mode at a constant strain rate and total deformation increment up to 5%. The stress–strain curves reveal jerky flow from the yield point to the formation of the neck. The digital speckle correlation method evidences the movement of localized plastic deformation bands under the conditions of the Portevin–Le Chatelier effect (PLC). It is shown that stress drops during jerky flow in Ni are accompanied by the formation of morphologically simple single PLC bands. It is established that, with an increase in total deformation, the number of PLC bands and their velocity of motion along the sample decrease, while their time period increases. Moreover, an increase in total deformation leads to an increase in the parameters of the force response (i.e., time period and stress drop magnitude). It is found that the criterion of damage for PLC bands as a function of the total strain has a sigmoidal shape.
Predicting Susceptibility to Solidification Cracking and Liquation Cracking by CALPHAD
Authors: Kou Sindo
Published: September 2021

In welding, liquation cracking can occur in the partially melted zone, leaving open cracks along the edge of the weld bead. Likewise, solidification cracking can occur in the mushy zone, leaving open cracks inside the weld bead (which is called the weld metal or fusion zone). The present study aims at demonstrating that CALPHAD-based modeling can help predict the susceptibility of alloys to both types of cracking. The basic relationship between temperature T and the fraction of solid fS of an alloy can be calculated using thermodynamic software and a database based on the alloy composition. For liquation cracking the T-fS curve of the weld metal can be compared with that of the workpiece to assess the susceptibility. For solidification cracking, on the other hand, the T-(fS)1/2 curve of the weld metal can be used to calculate the susceptibility. The composition of the weld metal depends on the compositions of the workpiece and the filler metal, and the percentage of the workpiece in the weld metal (called dilution). The susceptibility predictions based on these curves and comparison with welding experiments will be demonstrated using Al alloys, Mg alloys, and carbon steels as examples.
Adipose Tissue and Biological Factors. Possible Link between Lymphatic System Dysfunction and Obesity
Authors: Antoniak Klaudia , Hansdorfer-Korzon Rita , Mrugacz Małgorzata , Zorena Katarzyna
Published: September 2021

The World Health Organization (WHO) has recognised obesity as one of the top ten threats to human health. Obesity is not only a state of abnormally increased adipose tissue in the body, but also of an increased release of biologically active metabolites. Moreover, obesity predisposes the development of metabolic syndrome and increases the incidence of type 2 diabetes (T2DM), increases the risk of developing insulin resistance, atherosclerosis, ischemic heart disease, polycystic ovary syndrome, hypertension and cancer. The lymphatic system is a one-directional network of thin-walled capillaries and larger vessels covered by a continuous layer of endothelial cells that provides a unidirectional conduit to return filtered arterial and tissue metabolites towards the venous circulation. Recent studies have shown that obesity can markedly impair lymphatic function. Conversely, dysfunction in the lymphatic system may also be involved in the pathogenesis of obesity. This review highlights the important findings regarding obesity related to lymphatic system dysfunction, including clinical implications and experimental studies. Moreover, we present the role of biological factors in the pathophysiology of the lymphatic system and we propose the possibility of a therapy supporting the function of the lymphatic system in the course of obesity.
The Fabrication of Amino Acid Incorporated Nanoflowers with Intrinsic Peroxidase-like Activity and Its Application for Efficiently Determining Glutathione with TMB Radical Cation as Indicator
Authors: Jiang Ning , Zhang Chuang , Li Meng , Li Shuai , Hao Zhili , Li Zhengqiang , Wu Zhuofu , Li Chen
Published: September 2021

The assessment of glutathione (GSH) levels is associated with early diagnostics and pathological analysis for various disorders. Among all kinds of techniques for detecting GSH, the colorimetric assay relying on the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) catalyzed by many nanomaterials with peroxidase-like activity attracts increasing attention owing to its outstanding merits, such as high sensitivity and high selectivity. However, the aggregation between the nanomaterials severely hinders the entrance of TMB into the “active site” of these peroxidase mimics. To address this problem, the D-amino acid incorporated nanoflowers possessing peroxidase-like activity with a diameter of 10–15 μm, TMB and H2O2 were employed to establish the detection system for determining the level of glutathione. The larger diameter size of the hybrid nanoflowers substantially averts the aggregation between them. The results confirm that the hybrid nanoflowers detection system presents a low limit of detection, wide linear range, perfect selectivity, good storage stability and desired operational stability for the detection of GSH relying on the intrinsic peroxidase-like activity and favorable mechanical stability of the hybrid nanoflowers, indicating that the hybrid nanoflowers detection system has tremendous application potential in clinical diagnosis and treatment.
Biodegradation Potential and Putative Catabolic Genes of Culturable Bacteria from an Alpine Deciduous Forest Site
Authors: Poyntner Caroline , Kutzner Andrea , Margesin Rosa
Published: September 2021

Microbiota from Alpine forest soils are key players in carbon cycling, which can be greatly affected by climate change. The aim of this study was to evaluate the degradation potential of culturable bacterial strains isolated from an alpine deciduous forest site. Fifty-five strains were studied with regard to their phylogenetic position, growth temperature range and degradation potential for organic compounds (microtiter scale screening for lignin sulfonic acid, catechol, phenol, bisphenol A) at low (5 °C) and moderate (20 °C) temperature. Additionally, the presence of putative catabolic genes (catechol-1,2-dioxygenase, multicomponent phenol hydroxylase, protocatechuate-3,4-dioxygenase) involved in the degradation of these organic compounds was determined through PCR. The results show the importance of the Proteobacteria phylum as its representatives did show good capabilities for biodegradation and good growth at −5 °C. Overall, 82% of strains were able to use at least one of the tested organic compounds as their sole carbon source. The presence of putative catabolic genes could be shown over a broad range of strains and in relation to their degradation abilities. Subsequently performed gene sequencing indicated horizontal gene transfer for catechol-1,2-dioxygenase and protocatechuate-3,4-dioxygenase. The results show the great benefit of combining molecular and culture-based techniques.
Whole Genome Sequencing Based Taxonomic Classification, and Comparative Genomic Analysis of Potentially Human Pathogenic Enterobacter spp. Isolated from Chlorinated Wastewater in the North West Province, South Africa
Authors: Maguvu Tawanda E. , Bezuidenhout Cornelius C.
Published: September 2021

Comparative genomics, in particular, pan-genome analysis, provides an in-depth understanding of the genetic variability and dynamics of a bacterial species. Coupled with whole-genome-based taxonomic analysis, these approaches can help to provide comprehensive, detailed insights into a bacterial species. Here, we report whole-genome-based taxonomic classification and comparative genomic analysis of potential human pathogenic Enterobacter hormaechei subsp. hoffmannii isolated from chlorinated wastewater. Genome Blast Distance Phylogeny (GBDP), digital DNA-DNA hybridization (dDDH), and average nucleotide identity (ANI) confirmed the identity of the isolates. The algorithm PathogenFinder predicted the isolates to be human pathogens with a probability of greater than 0.78. The potential pathogenic nature of the isolates was supported by the presence of biosynthetic gene clusters (BGCs), aerobactin, and aryl polyenes (APEs), which are known to be associated with pathogenic/virulent strains. Moreover, analysis of the genome sequences of the isolates reflected the presence of an arsenal of virulence factors and antibiotic resistance genes that augment the predictions of the algorithm PathogenFinder. The study comprehensively elucidated the genomic features of pathogenic Enterobacter isolates from wastewaters, highlighting the role of wastewaters in the dissemination of pathogenic microbes, and the need for monitoring the effectiveness of the wastewater treatment process.
Characterization of Phosphate Solubilizing Bacterial Endophytes and Plant Growth Promotion In Vitro and in Greenhouse
Authors: Mei Chuansheng , Chretien Robert L. , Amaradasa B. Sajeewa , He Yimeng , Turner Amy , Lowman Scott
Published: September 2021

Phosphate is one of the most important nutrients for plant growth and development, and only 0.1% of the phosphate in soils is available to plants. Currently, the use of excess phosphate fertilizer has caused surface and ground water pollution and water eutrophication, resulting in algal blooms in lakes and oceans. Therefore, it is imperative to explore alternative ways to solve these problems for sustainable agricultural production and improvement of soil fertility, while protecting the environment. Microorganisms from the rhizosphere and within plants are able to solubilize insoluble soil phosphate, making it available to plants. Five high phosphate solubilizing bacteria from our bacterial endophyte library were chosen for this study and identified as Pantoea vagans IALR611, Pseudomonas psychrotolerans IALR632, Bacillus subtilis IALR1033, Bacillus safensis IALR1035 and Pantoea agglomerans IALR1325. All five bacteria significantly promoted tall fescue growth in vitro. Greenhouse experiments showed that IALR1325 significantly promoted pepper and tomato growth, and IALR632 was the best in promoting tomato growth. In addition, all these bacteria had extracellular acid phosphatase and phytase activities. One of the mechanisms for phosphate solubilization by bacteria is pH reduction caused by gluconic acid production. Our results indicate that P. agglomerans IALR1325 is a promising bacterium for future applications.
Behavioral and Neurochemical Shifts at the Hippocampus and Frontal Cortex Are Associated to Peripheral Inflammation in Balb/c Mice Infected with Brucella abortus 2308
Authors: Maldonado-García José Luis , Pérez-Sánchez Gilberto , Becerril Villanueva Enrique , Alvarez-Herrera Samantha , Pavón Lenin , Gutiérrez-Ospina Gabriel , López-Santiago Rubén , Maldonado-Tapia Jesús Octavio , Pérez-Tapia Sonia Mayra , Moreno-Lafont Martha C.
Published: September 2021

Brucellosis is a zoonosis affecting 50,000,000 people annually. Most patients progress to a chronic phase of the disease in which neuropsychiatric symptoms upsurge. The biological processes underlying the progression of these symptoms are yet unclear. Peripheral inflammation mounted against Brucella may condition neurochemical shifts and hence unchained neuropsychiatric disorders. Our work aimed at establishing whether neurological, behavioral, and neurochemical disarrays are circumstantially linked to peripheral inflammation uprise secondary to Brucella abortus 2308 infections. We then evaluated, in control and Brucella-infected mice, skeletal muscle strength, movement coordination, and balance and motivation, as well as dopamine, epinephrine, norepinephrine, and serotonin availability in the cerebellum, frontal cortex, and hippocampus. Serum levels of proinflammatory cytokines and corticosterone in vehicle-injected and -infected mice were also estimated. All estimates were gathered at the infection acute and chronic phases. Our results showed that infected mice displayed motor disabilities, muscular weakness, and reduced motivation correlated with neurochemical and peripheral immunological disturbances that tended to decrease after 21 days of infection. The present observations support that disturbed peripheral inflammation and the related neurochemical disruption might lead to mood disorders in infected mice. Future experiments must be aimed at establishing causal links and to explore whether similar concepts might explain neurological and mood disorders in humans affected by brucellosis.
Human Milk Oligosaccharide-Stimulated Bifidobacterium Species Contribute to Prevent Later Respiratory Tract Infections
Authors: Dogra Shaillay Kumar , Martin Francois-Pierre , Donnicola Dominique , Julita Monique , Berger Bernard , Sprenger Norbert
Published: September 2021

(1) Background: Human milk oligosaccharides (HMOs) may support immune protection, partly via their action on the early-life gut microbiota. Exploratory findings of a randomized placebo-controlled trial associated 2′fucosyllactose (2′FL) and lacto-N-neotetraose (LNnT) formula feeding with reduced risk for reported bronchitis and lower respiratory tract illnesses (LRTI), as well as changes in gut microbiota composition. We sought to identify putative gut microbial mechanisms linked with these clinical observations. (2) Methods: We used stool microbiota composition, metabolites including organic acids and gut health markers in several machine-learning-based classification tools related prospectively to experiencing reported bronchitis or LRTI, as compared to no reported respiratory illness. We performed preclinical epithelial barrier function modelling to add mechanistic insight to these clinical observations. (3) Results: Among the main features discriminant for infants who did not experience any reported bronchitis (n = 80/106) or LRTI (n = 70/103) were the 2-HMO formula containing 2′FL and LNnT, higher acetate, fucosylated glycans and Bifidobacterium, as well as lower succinate, butyrate, propionate and 5-aminovalerate, along with Carnobacteriaceae members and Escherichia. Acetate correlated with several Bifidobacterium species. By univariate analysis, infants experiencing no bronchitis or LRTI, compared with those who did, showed higher acetate (p < 0.007) and B. longum subsp. infantis (p ≤ 0.03). In vitro experiments demonstrate that 2′FL, LNnT and lacto-N-tetraose (LNT) stimulated B. longum subsp. infantis (ATCC15697) metabolic activity. Metabolites in spent culture media, primarily due to acetate, supported epithelial barrier protection. (4) Conclusions: An early-life gut ecology characterized by Bifidobacterium-species-driven metabolic changes partly explains the observed clinical outcomes of reduced risk for bronchitis and LRTI in infants fed a formula with HMOs. (Trial registry number NCT01715246.).
Characterization of the Subgingival Cultivable Microbiota in Patients with Different Stages of Periodontitis in Spain and Colombia. A Cross-Sectional Study
Authors: Pianeta Roquelina , Iniesta Margarita , Castillo Diana Marcela , Lafaurie Gloria I. , Sanz Mariano , Herrera David
Published: September 2021

The objective was to characterize and compare the subgingival microbiota in patients diagnosed according to the World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions 2018. For this cross-sectional study, Spanish and Colombian subjects (characterized as health/gingivitis, periodontitis in stages I-II or stages III-IV) were clinically assessed, and subgingival samples were taken and processed by culture. The comparisons among patients with periodontal status (and between countries) was made using Mann–Whitney, Kruskal–Wallis, ANOVA and chi-square tests. The final sample consisted of 167 subjects. Eikenella corrodens and Parvimonas micra were more frequently detected in health/gingivitis and Porphyromonas gingivalis in periodontitis (p < 0.05). Higher total counts were observed in Colombia (p = 0.036). In Spain, significantly higher levels of P. gingivalis and Campylobacter rectus were observed, and of Tannerella forsythia, P. micra, Prevotella intermedia, Fusobacterium nucleatum, Actinomyces odontolyticus and Capnocytophaga spp. in Colombia (p < 0.001). P. micra was more prevalent in health/gingivitis and stage I-II periodontitis in Colombia, and P. gingivalis in all periodontitis groups in Spain (p < 0.05). As conclusions, significant differences were detected in the microbiota between health/gingivitis and periodontitis, with minor differences between stages of periodontitis. Differences were also relevant between countries, with Colombia showing larger counts and variability of bacterial species.
Effect of Fly Ash on the Mechanical Properties and Microstructure of Cement-Stabilized Materials with 100% Recycled Mixed Aggregates
Authors: Meng Tao , Dai Dawang , Yang Xiufen , Yu Hongming
Published: September 2021

The use of recycled mixed aggregates (RMA) in cement-stabilized materials (CSM) is an effective way to dispose of and reuse demolition waste. However, this approach faces various challenges; for example, the drying shrinkage of CSM with 100% RMA is very high, which is unfavorable for use in road engineering. In order to use a simple method to reduce the drying shrinkage of the CSM with 100% RMA and give it reliable strength, the effect of fly ash on the mechanical properties, drying shrinkage, and abrasion resistance of CSM with 100% RMA was investigated in this study, and the mechanism was examined by X-ray Diffraction (XRD), Mercury Intrusion Porosimetry (MIP), and Scanning Electron Microscopy (SEM). The results revealed that the addition of fly ash would decrease the drying shrinkage of CSM with 100% RMA. Moreover, when the amount of fly ash was less than 20%, the later strength increased remarkably despite the slight decrease in the early unconfined compressive strength, indirect tensile strength, compressive and splitting elastic modulus, and abrasion resistance of CSM with 100% RMA. The microstructure analysis results indicated that fly ash increased the decline range of diffraction intensity of C2S and C3S at a later age and also helped to optimize the pore structure. Research results of this article can be used to optimize the mechanical properties of CSM with 100% RMA and guide its application in road base.
Paleoenvironment Implication of Red Paleosols in a Late Cretaceous Continental Succession, Songliao Basin, NE China
Authors: Zhang Li , Zhang Changmin , Dou Luxing
Published: September 2021

The limited knowledge of Late Cretaceous terrestrial environments and their response to tectonic events in mid-latitudes can be addressed through continental basin deposits such as paleosols. Paleosols have been discovered in the Late Cretaceous Yaojia Formation in the southern Songlaio Basin and are recognized by evidence of soil structures controlled by pedogenesis. Sedimentary facies research on red paleosols was conducted on the Late Cretaceous Yaojia Formation in the outcrop of the southern Songliao Basin to interpret the depositional environments and tectonic significance of red paleosols during the greenhouse period. Mudflat, lake margin, and shallow lake depositional environments in a semi-arid climate are interpreted from the outcrops based on sedimentary descriptions and interpretation as well as geochemical and micromorphological analyses of paleosols in outcrops. We reconstructed the paleoenvironmental and paleoclimatic conditions through the paleosols in the mudflats and lake margin. The red paleosols in the mudflats and lake margin deposits formed in a stable landscape influenced by the tectonic uplift of the Songliao Basin, which is considered as new important evidence for tectonic uplift influenced by the collision of the Okhotomorsk Block with East Asia. The tectonic uplift process in East Asia is identified from the evolution of the depositional environments and drainage conditions inferred from different types of paleosols. Thus, the paleosols-bearing red bed deposits in outcrops provide an important contribution of the Late Cretaceous terrestrial paleoclimate and the tectonic setting research.
Long Term Application of Fertilizers in Eastern Amazon and Effect on Uranium and Thorium Levels in Soils
Authors: de Souza Braz Anderson Martins , da Costa Marcondes Lima , Ramos Sílvio Junio , Dall’Agnol Roberto , Fernandes Antonio Rodrigues
Published: September 2021

In recent years, the use of fertilizers has increased in the Amazon. Phosphate fertilizers, which are commonly used, can present high concentrations of radioelements. In the present study, the activity concentrations of uranium (U) and thorium (Th) in Oxisols and Ultisols cultivated with citrus (Citrus sinensis (L.) Osbeck), oil palm (Elaeis guineensis Jacq.) and black pepper (Piper nigrum L.), with 26, 10 and 5 years of implantation, respectively, were evaluated. The potential risk of contamination was estimated by the enrichment (EF) and bioaccumulation (BAF) factors. Pearson’s correlation coefficients indicated a significant relationship between the concentrations of U and Th in soil and plant and the soil properties pH, Ca2+, Mg2+, K+ and P. The enrichment (EF < 2) and bioaccumulation (0.01 < BAF < 0.05) factors were low. In plant tissues, the concentrations of 238U followed the order: citrus > black pepper > oil palm, and the concentrations of 232Th followed the sequence: black pepper >> citrus > oil palm. The activity concentrations of 238U and 232Th in the soil cultivated with black pepper, as well as in the soil of the reference area close to the citrus plantation, were higher than the world average values of 35 and 30 Bq kg−1, respectively, established by the United Nations Scientific Committee on Effects of Atomic Radiation. Perennial crops that are fertilized annually must be monitored by environmental agencies due the accumulation of elements that can promote potential risks to human health.
Study Protocol to Determine Association between Environmental Triggers and Asthma among Children in King Williams Town
Authors: Yusuf Rasaq A. , Rathebe Phoka C. , Utembe Wells
Published: September 2021

Asthma affects over 330 million people worldwide, with relatively higher disease burdens in Australia, New Zealand, Africa, the Middle East, and South America. The symptoms associated with asthma were reported to be prevalent in children from the period of 1993 to 2013, in many low- and middle-income countries, due to changes in environmental conditions, such as domestic lifestyle, and urban and industrial developments. (1) Background: Several studies have also shown that children are prone to a severe type of asthma, because of their narrow respiratory airways and susceptibility to irritation from environmental agents. This study aimed to assess the association between environmental exposure and asthma among children in King Williams Town, South Africa. (2) Methodology: This study adopted a cross-sectional design method, with an estimated sample size of 262 participants. The eligible study participants were enrolled while attending Grey hospital in King Williams Town, for asthma management. Information will be collected from eligible, stable participants, on asthma treatment, through in-person interviewing in 2021. A semi-structured questionnaire will be administered to the participants. However, as a result of the prevailing COVID-19 pandemic, data may be abstracted from the asthma medical record of the eligible participants. Multivariate regression will be utilized, to describe the correlation between the variables, and the odds ratio will be calculated as well. (3) Discussion and conclusion: The study will objectively identify the local environmental agents that are associated with asthma among children in King Williams Town, in order to reprioritize treatment and preventative strategies. Ethical approval was obtained from the Research Ethics Committee, Faculty of Health Sciences at the University of Johannesburg.
Improvement of the Collection, Maintenance, and Analysis of Neoplastic Cells from Urine Specimens with the Use of CytoMatrix
Authors: Minasi Simone , Bosco Daniela , Moretti Bernardo , Giangaspero Felice , Santoro Antonio , Buttarelli Francesca Romana
Published: September 2021

Urine cytology is a non-invasive test used in combination with cystoscopy for screening and follow-up of urothelial carcinoma (UC). Although cytology can be used to efficiently identify high-grade UC, it has a lower accuracy for the diagnosis of low-grade UC or patients with presence of atypical urothelial cells (AUC). For these reasons, ancillary tests have been added to urine cytology in order to improve the accuracy. However, the poor abundance of neoplastic cells in most samples and the absence of a “tissue-like” structure remains a major challenge. We used a novel synthetic support called CytoMatrix which has the property of capturing and storing cells and micro-macro aggregates within its three-dimensional structure. The urine specimens were obtained from 12 patients: 6 with suspected urothelial neoplasia (low- and high-grade) and 6 with AUC or non-neoplastic samples. The first step is the urine samples preparation, through several centrifugation passages; the second step consists in absorbing cells on the CytoMatrix, and in the subsequent formalin fixation, standard processing and paraffin embedding to prepare FFPE-CytoMatrix block. In the final step, sections are consecutively cut, stained with hematoxylin-eosin (H&E), and analyzed via UroVysion FISH and immunohistochemistry (IHC). Using our simple and reliable protocol, we can improve the quality of urine specimens, allowing a better collection, maintenance, and analysis of cells, with the advantage of using ancillary tests to support cytological diagnosis and the advantage of storing cellular material in a FFPE-CytoMatrix block.
Wettability Changes Due to Nanomaterials and Alkali—A Proposed Formulation for EOR
Authors: Saleh Samhar , Neubauer Elisabeth , Borovina Ante , Hincapie Rafael E. , Clemens Torsten , Ness Daniel
Published: September 2021

We investigated the usage of two silica nanomaterials (surface-modified) and alkali in enhanced oil recovery through Amott spontaneous imbibition tests, interfacial tension (IFT) measurements, and phase behavior. We evaluated the wettability alteration induced by the synergy between nanomaterials and alkali. Moreover, numerical analysis of the results was carried out using inverse Bond number and capillary diffusion coefficient. Evaluations included the use of Berea and Keuper outcrop material, crude oil with different total acid numbers (TAN), and Na2CO3 as alkaline agent. Data showed that nanomaterials can reduce the IFT, with surface charge playing an important role in this process. In synergy with alkali, the use of nanomaterials led to low-stable IFT values. This effect was also seen in the phase behavior tests, where brine/oil systems with lower IFT exhibited better emulsification. Nanomaterials’ contribution to the phase behavior was mainly the stabilization of the emulsion middle phase. The influence of TAN number on the IFT and phase behavior was prominent especially when combined with alkali. Amott spontaneous imbibition resulted in additional oil recovery ranging from 4% to 50% above the baseline, which was confirmed by inverse Bond number analysis. High recoveries were achieved using alkali and nanomaterials; these values were attributed to wettability alteration that accelerated the imbibition kinetics as seen in capillary diffusion coefficient analysis.
Adsorption Performance of Amino Functionalized Magnetic Molecular Sieve Adsorbent for Effective Removal of Lead Ion from Aqueous Solution
Authors: Guo Chuanen , Wang Yingying , Wang Fangzheng , Wang Yaoguang
Published: September 2021

Lead ion (Pb2+) has high toxicity and brings great harm to human body. It is very important to find an effective method to address lead ion pollution. In this work, amino functionalized CoFe2O4/SBA–15 nanocomposite (NH2–CoFe2O4/SBA–15) was prepared for the effective removal of Pb2+ from aqueous solution. The prepared NH2–CoFe2O4/SBA–15 adsorbent was manifested by using scanning electron microscope (SEM), energy dispersive spectroscopy (EDS), Fourier transform infrared spectrum (FTIR), X-ray powder diffraction (XRD), and Brunauer-Emmett-Teller (BET) analysis. In the meantime, the adsorption conditions, including pH, adsorbent dosage, and adsorption time, were studied. The investigation of adsorption kinetics revealed that the adsorption results conform to the pseudo-first-order kinetic model. The adsorption isotherms research displayed that the adsorption was consistent with the Freundlich model, demonstrating that the adsorption for Pb2+ with the prepared adsorbent was a multimolecular layer adsorption process. In addition, the thermodynamic investigations (ΔG < 0, ΔH > 0, ΔS > 0) demonstrated that the adsorption for Pb2+ with the prepared adsorbent was endothermic and spontaneous. Moreover, the prepared adsorbent showed superior anti-interference performance and reusability, implying the potential application of the adsorbent in actual water treatment. Furthermore, this research may provide a reference and basis for the study of other heavy metal ions.
Influence of Titanium Dioxide Nanoparticles on Human Health and the Environment
Authors: Rashid Mohammad Mamunur , Forte Tavčer Petra , Tomšič Brigita
Published: September 2021

Nanotechnology has enabled tremendous breakthroughs in the development of materials and, nowadays, is well established in various economic fields. Among the various nanomaterials, TiO2 nanoparticles (NPs) occupy a special position, as they are distinguished by their high availability, high photocatalytic activity, and favorable price, which make them useful in the production of paints, plastics, paper, cosmetics, food, furniture, etc. In textiles, TiO2 NPs are widely used in chemical finishing processes to impart various protective functional properties to the fibers for the production of high-tech textile products with high added value. Such applications contribute to the overall consumption of TiO2 NPs, which gives rise to reasonable considerations about the impact of TiO2 NPs on human health and the environment, and debates regarding whether the extent of the benefits gained from the use of TiO2 NPs justifies the potential risks. In this study, different TiO2 NPs exposure modes are discussed, and their toxicity mechanisms—evaluated in various in vitro and in vivo studies—are briefly described, considering the molecular interactions with human health and the environment. In addition, in the conclusion of this study, the toxicity and biocompatibility of TiO2 NPs are discussed, along with relevant risk management strategies.
Self-Sensing Cementitious Composites: Review and Perspective
Authors: Bekzhanova Zere , Memon Shazim Ali , Kim Jong Ryeol
Published: September 2021

Self-sensing concrete (SSC) has been vastly studied for its possibility to provide a cost-effective solution for structural health monitoring of concrete structures, rendering it very attractive in real-life applications. In this review paper, comprehensive information about the components of self-sensing concrete, dispersion methods and mix design, as well as the recent progress in the field of self-sensing concrete, has been provided. The information and recent research findings about self-sensing materials for smart composites, their properties, measurement of self-sensing signal and the behavior of self-sensing concrete under different loading conditions are included. Factors influencing the electrical resistance of self-sensitive concrete such as dry-wet cycle, ice formation and freeze thaw cycle and current frequency, etc., which were not covered by previous review papers on self-sensing concrete, are discussed in detail. Finally, major emphasis is placed on the application of self-sensing technology in existing and new structures.
Carbon Nanostructures, Nanolayers, and Their Composites
Authors: Slepičková Kasálková Nikola , Slepička Petr , Švorčík Václav
Published: September 2021

The versatility of the arrangement of C atoms with the formation of different allotropes and phases has led to the discovery of several new structures with unique properties. Carbon nanomaterials are currently very attractive nanomaterials due to their unique physical, chemical, and biological properties. One of these is the development of superconductivity, for example, in graphite intercalated superconductors, single-walled carbon nanotubes, B-doped diamond, etc. Not only various forms of carbon materials but also carbon-related materials have aroused extraordinary theoretical and experimental interest. Hybrid carbon materials are good candidates for high current densities at low applied electric fields due to their negative electron affinity. The right combination of two different nanostructures, CNF or carbon nanotubes and nanoparticles, has led to some very interesting sensors with applications in electrochemical biosensors, biomolecules, and pharmaceutical compounds. Carbon materials have a number of unique properties. In order to increase their potential application and applicability in different industries and under different conditions, they are often combined with other types of material (most often polymers or metals). The resulting composite materials have significantly improved properties.
Amino-Functionalized Fe3O4@SiO2 Core-Shell Magnetic Nanoparticles for Dye Adsorption
Authors: Lin Chun-Rong , Ivanova Oxana S. , Petrov Dmitry A. , Sokolov Alexey E. , Chen Ying-Zhen , Gerasimova Marina A. , Zharkov Sergey M. , Tseng Yaw-Teng , Shestakov Nicolay P. , Edelman Irina S.
Published: September 2021

Fe3O4@SiO2 core-shell nanoparticles (NPs) were synthesized with the co-precipitation method and functionalized with NH2 amino-groups. The nanoparticles were characterized by X-ray, FT-IR spectroscopy, transmission electron microscopy, selected area electron diffraction, and vibrating sample magnetometry. The magnetic core of all the nanoparticles was shown to be nanocrystalline with the crystal parameters corresponding only to the Fe3O4 phase covered with a homogeneous amorphous silica (SiO2) shell of about 6 nm in thickness. The FT-IR spectra confirmed the appearance of chemical bonds at amino functionalization. The magnetic measurements revealed unusually high saturation magnetization of the initial Fe3O4 nanoparticles, which was presumably associated with the deviations in the Fe ion distribution between the tetrahedral and octahedral positions in the nanocrystals as compared to the bulk stoichiometric magnetite. The fluorescent spectrum of eosin Y-doped NPs dispersed in water solution was obtained and a red shift and line broadening (in comparison with the dye molecules being free in water) were revealed and explained. Most attention was paid to the adsorption properties of the nanoparticles with respect to three dyes: methylene blue, Congo red, and eosin Y. The kinetic data showed that the adsorption processes were associated with the pseudo-second order mechanism for all three dyes. The equilibrium data were more compatible with the Langmuir isotherm and the maximum adsorption capacity was reached for Congo red.
Challenges in Drug Discovery for Intracellular Bacteria
Authors: Tucker Allison N. , Carlson Travis J. , Sarkar Aurijit
Published: September 2021

Novel drugs are needed to treat a variety of persistent diseases caused by intracellular bacterial pathogens. Virulence pathways enable many functions required for the survival of these pathogens, including invasion, nutrient acquisition, and immune evasion. Inhibition of virulence pathways is an established route for drug discovery; however, many challenges remain. Here, we propose the biggest problems that must be solved to advance the field meaningfully. While it is established that we do not yet understand the nature of chemicals capable of permeating into the bacterial cell, this problem is compounded when targeting intracellular bacteria because we are limited to only those chemicals that can permeate through both human and bacterial outer envelopes. Unfortunately, many chemicals that permeate through the outer layers of mammalian cells fail to penetrate the bacterial cytoplasm. Another challenge is the lack of publicly available information on virulence factors. It is virtually impossible to know which virulence factors are clinically relevant and have broad cross-species and cross-strain distribution. In other words, we have yet to identify the best drug targets. Yes, standard genomics databases have much of the information necessary for short-term studies, but the connections with patient outcomes are yet to be established. Without comprehensive data on matters such as these, it is difficult to devise broad-spectrum, effective anti-virulence agents. Furthermore, anti-virulence drug discovery is hindered by the current state of technologies available for experimental investigation. Antimicrobial drug discovery was greatly advanced by the establishment and standardization of broth microdilution assays to measure the effectiveness of antimicrobials. However, the currently available models used for anti-virulence drug discovery are too broad, as they must address varied phenotypes, and too expensive to be generally adopted by many research groups. Therefore, we believe drug discovery against intracellular bacterial pathogens can be advanced significantly by overcoming the above hurdles.
Electrical Characterizations of 35-kV Semi-Insulating Gallium Arsenide Photoconductive Switch
Authors: Ma Cheng , Wu Meilin , Wang Wennan , Jia Yaqiong , Shi Wei
Published: September 2021

In this paper, a three-layer GaAs photoconductive semiconductor switch (GaAs PCSS) is designed to withstand high voltage from 20 to 35 kV. The maximum avalanche gain and minimum on-state resistance of GaAs PCSS are 1385 and 0.58 Ω, respectively, which are the highest values reported to date. Finally, the influence of the bias voltage on the avalanche stability is analyzed. The stability of the GaAs PCSS is evaluated and calculated. The results show that the jitter values at the bias voltages of 30 kV and 35 kV are 164.3 ps and 106.9 ps, respectively. This work provides guidance for the design of semiconductor switches with high voltage and high gain.
Double Mutant Analysis with the Large Flower Mutant, ohbana1, to Explore the Regulatory Network Controlling the Flower and Seed Sizes in Arabidopsis thaliana
Authors: Nhat Vuong Quoc , Kazama Yusuke , Ishii Kotaro , Ohbu Sumie , Kunitake Hisato , Abe Tomoko , Hirano Tomonari
Published: September 2021

Two growth processes, cell proliferation and expansion, determine plant species-specific organ sizes. A large flower mutant in Arabidopsis thaliana, ohbana1 (ohb1), was isolated from a mutant library. In the ohb1 flowers, post-mitotic cell expansion and endoreduplication of nuclear DNA were promoted. The whole-genome resequencing and genetic analysis results showed that the loss of function in MEDIATOR16 (MED16), a mediator complex subunit, was responsible for the large flower phenotypes exhibited by ohb1. A phenotypic analysis of the mutant alleles in MED16 and the double mutants created by crossing ohb1 with representative large flower mutants revealed that MED16 and MED25 share part of the negative petal size regulatory pathways. Furthermore, the double mutant analyses suggested that there were genetically independent pathways leading to cell size restrictions in the floral organs which were not related to the MED complex. Several double mutants also formed larger and heavier seeds than the wild type and single mutant plants, which indicated that MED16 was involved in seed size regulation. This study has revealed part of the size-regulatory network in flowers and seeds through analysis of the ohb1 mutant, and that the size-regulation pathways are partially different between floral organs and seeds.
Identification and Characterization of Verticillium nonalfalfae-Responsive MicroRNAs in the Roots of Resistant and Susceptible Hop Cultivars
Authors: Kunej Urban , Jakše Jernej , Radišek Sebastjan , Štajner Nataša
Published: September 2021

MicroRNAs are 21- to 24-nucleotide-long, non-coding RNA molecules that regulate gene expression at the post-transcriptional level. They can modulate various biological processes, including plant response and resistance to fungal pathogens. Hops are grown for use in the brewing industry and, recently, also for the pharmaceutical industry. Severe Verticillium wilt caused by the phytopathogenic fungus Verticillium nonalfalfae, is the main factor in yield loss in many crops, including hops (Humulus lupulus L.). In our study, we identified 56 known and 43 novel miRNAs and their expression patterns in the roots of susceptible and resistant hop cultivars after inoculation with V. nonalfalfae. In response to inoculation with V. nonalfalfae, we found five known and two novel miRNAs that are differentially expressed in the susceptible cultivar and six known miRNAs in the resistant cultivar. Differentially expressed miRNAs target 49 transcripts involved in protein localization and pigment synthesis in the susceptible cultivar, whereas they are involved in transcription factor regulation and hormone signalling in the resistant cultivar. The results of our study suggest that the susceptible and resistant hop cultivars respond differently to V. nonalfalfae inoculation at the miRNA level and that miRNAs may contribute to the successful defence of the resistant cultivar.
Development of an Adaptive Model for the Rate of Steel Corrosion in a Recirculating Water System
Authors: Huang Xiaochuan , Gao Yan , Zhu Ling , He Ge
Published: September 2021

The stable quality of circulating water ensures the long-term stable operation of various processes in petrochemical production and achieves energy savings and emission reduction while reducing environmental pollution and yielding economic benefits to petrochemical enterprises. However, traditional circulating water quality evaluation and modeling for corrosion rate prediction suffer from adaptability and accuracy problems. To address these problems, the water quality analysis data of the circulating water in the field were subjected to data preprocessing and water quality index calculation to perform feature engineering, followed by modeling using a machine learning method that integrates the adaptive immune genetic algorithm and random forest (RF) algorithm and can intelligently select the water quality parameters to be used as the input variables for the RF modeling. Finally, the method was validated using an industrial example, and the results indicate that the method is capable of removing interference variables and is suitable for carbon steel corrosion rate prediction based on water quality models. The proposed method provides a basis for water quality management and real-time decision-making by circulating water field personnel.
Faith-Inspired Muslim Parents’ School Choices and Attitudes in the Cultural West and Australia
Authors: Iner Derya
Published: September 2021

All parents want the best accessible, available and affordable school for their children. Yet, the literature highlights that school choice for middle-class parents in the cultural West is a deliberate decision and a reflection of their salient identities. For racialised middle-class Western parents, school choice is an instrumental investment to secure social upward mobility and minimise the harms of racism for their children. Research focusing on Western middle-class Muslim parents highlights that accommodation of Muslim identities and ethno-religious values is pivotal in parental school choice. This is expected due to the rise of Islamophobia in the cultural West since 9/11. The semi-structured interviews with faith-inspired middle-class Muslim parents in Australia bring a new dimension to the parental school choice literature. Regardless of carrying more or less similar concerns for their children in an Islamophobic climate, middle-class Muslim parents’ school choices vary based on their childhood schooling experiences in the Australian context, diverse parenting styles and mentalities and their children’s varying personalities demanding a particular type of school setting. This article demonstrates there is no one size fits all Muslim parent in terms of deciding which school is the best for their children in an Islamophobic climate.
Novel Cooperative Scheme Based on Joint Band Assignment and Power Allocation for a Coexisting Radar-Communications System
Authors: Chen Yufeng , Liao Guisheng , Yang Zhiwei , Liu Yongjun , Jiang Mengchao
Published: September 2021

In this paper, we present a novel cooperative scheme of joint optimal resource allocation, such that the overall performance of the coexisting radar-communications (CRC) system can be improved. In our proposed scheme, target detection and multiuser communication are performed by radar and communication subsystems at the same time, as well as a control center, which is responsible for joint resource management. We aim to minimize the ISLR for target detection and maximize the sum-rate for communications simultaneously by jointly optimizing the band assignment and transmit power allocation. Since the resulting optimization problem involving two performance metrics and a binary constraint is a multiobjective nonconvex problem, a two-tier iterative decomposition (TT-ID) approach is devised to obtain the globally optimal solution. However, compared with the conventional radar signals, the autocorrelation function of the devised radar signal may still have relatively high sidelobes. In particular, when the data transmission becomes the primary purpose of the CRC system, the sidelobe performance gets worse. As a consequence, some weak targets are most likely overshadowed by the adjacent strong targets through the matched filtering at the radar receiver. To address this, a spectral estimation algorithm based on the Bayes Cauchy–Gaussian (Bayes–CG) model is employed to further reduce the range sidelobes of the matched filter output at the radar receiver according to the prior distribution of the desired autocorrelation. Finally, several numerical results are provided to show the merits of the proposed method.