bluuebunny/crossref_metadata_2025 huggingface dataset:
Aplikasi Quality Function Deployment (QFD) Untuk Meningkatkan Kualitas Produk Garmen
Authors: Nurmianto Eko
Published: January 2023

Setiap perusahaan menginginkan usahanya sukses dan mampu bertahan lama. Demikian halnya dengan objek penelitian ini yaitu di Industri Kecil Garmen X dan pesaing yang memproduksi garmen yang pembuatannya menggunakan mesin otomatis. Bagaimanapun industry kecil menghendaki penjualannya makin meningkat dan mampu bersaing dengan produk merk lain dengan Aplikasi Quality Function Deployment (QFD) Untuk Meningkatkan Kualitas Produk Garmen. Tujuan penelitian ini merumuskan strategi yang tepat untuk memenuhi kepuasan konsumen garmen dengan mengaplikasikan metode Quality Function Deployment (QFD) dengan mengintegrasikan Triangular Fuzzy’s Number. Berdasarkan tujuan ini maka hasil penelitian adalah bagaimana cara peningkatan kualitas garmen yang diproduksi sehingga mampu meningkatkan kepuasan konsumen. Semakin meningkatnya kepuasan konsumen maka diharapkan volume penjualan juga meningkat. Kesimpulan penelitian ini memberikan suatu perencanaan yang strategis melalui analisa QFD sehingga mampu meningkatkan kualitas produk dan kepuasan konsumen sehingga perusahaan mampu bersaing dengan produk garmen lainnya.
Adult-Onset Idiopathic Cervical Dystonia
Authors: Rafee Shameer , Al-Hinai Mahmood , Hutchinson Michael
Published: January 2023

Adult-onset idiopathic focal dystonia is the most common type of primary dystonia, and adult-onset idiopathic cervical dystonia (AOICD) is its most prevalent phenotype. AOICD is an autosomal-dominant disorder with markedly reduced penetrance; clinical expression is dependent on age, sex, and environmental exposure. Motor symptoms at presentation are poorly recognised by non-specialists, leading to long delays in diagnosis. Certain features of history and examination can help diagnose cervical dystonia. There is a relatively high prevalence of anxiety and/or depression, which adversely affects health-related quality of life. Recent studies indicate that patients with AOICD also have disordered social cognition, particularly affecting emotional sensory processing. AOICD can be treated reasonably effectively with botulinum toxin injections, given at 3-month intervals. Oral antidystonic medications are often trialled initially, but are largely ineffective. Comprehensive modern management of patients with AOICD requires recognition of presence of mood disorders, and actively treating the endogenous mood disorder with antidepressant therapy. Botulinum toxin injections alone, no matter how expertly given, will not provide optimal therapy and improved health-related quality of life without an holistic approach to patient management. Increasing evidence indicates that AOICD is a neurophysiological network disorder of GABAergic inhibition, causing a syndrome of dystonia, mood disturbance, and social cognitive dysfunction, with the superior colliculus playing a central role.
The Treatment Algorithm in Diabetic Foot: An Alternative Against Amputation?
Authors: Güçer Tacettin
Published: January 2023

This clinical treatment modality was applied to 62 diabetic ulcers on lower extremities for which surgeons had been advised amputation. Total healing was achieved in 53 of them and was achieved through this treatment in a 3-month period. The remaining nine cases also showed improvement in healing at different levels, but they were not accepted as a ‘satisfactory result’. This treatment modality contains a synthetic prostacyclin analogue, two different phosphodiesterase inhibitors, a peripheral revascularisation agent, another agent increasing peripheral resistance to ischaemia, and a polysaccharide with positive rheologic properties on capillary circulation. Therefore, this treatment was found to be effective on circulation of the extremities, with radiologically-proven insufficient blood supply. The treatment also had a positive effect on recirculation and effects on collateral revascularisation through mechanical vacuum application, modified from standard vacuum treatments. With this combination, this technique was found extremely effective by application, according to the algorithm explained below, and should be an alternative to the current therapy applications in diabetic ulcers.
The Rise of Anti-TNF Biosimilars: Guidelines, Real-World Evidence, and Challenges to Acceptance
Authors: Humphry Nicola
Published: January 2023

The over-production of TNF-α can lead to chronic inflammation and organ damage in immune-mediated inflammatory diseases (IMID), such as rheumatoid arthritis (RA), axial spondyloarthritis, psoriasis, and inflammatory bowel disease (IBD). Anti-TNF therapy is generally considered to be an effective, well-tolerated treatment option for the management of chronic inflammation in these conditions.
Over the past decade, patents for the original reference anti-TNF agents have expired, permitting the development of anti-TNF products that are biologically similar, termed ‘biosimilar’, to the original reference product. Differences in the approval process mean that biosimilars are often available to healthcare services at a considerably lower cost compared with the reference products, providing an opportunity to improve patient access to the benefits of anti-TNF therapy.
However, despite the spreading use of biosimilars across healthcare services, some clinicians remain reluctant to prescribe them. The gradual accumulation of long-term data on the real-world use of biosimilars, and an improved understanding of the development and approval process for these products, may help to increase clinicians’ confidence to increase usage of biosimilars.
This mini review summarises the current status of anti-TNF biosimilars in clinical practice, including the requirements for regulatory approval, real-word evidence for their equivalence to novel anti-TNFs, guidelines for their use, and challenges to their acceptance by both clinicians and patients.
Percutaneous Coronary Intervention and Bleeding Complications
Authors: George Sudhakar , Butler Rob , Nolan James , Mamas Mamas A.
Published: January 2023

Percutaneous coronary intervention (PCI) is the most common form of revascularisation in patients with coronary artery disease in both the elective and acute coronary syndrome settings. Advances in pharmacotherapy have reduced ischaemic complications and improved outcomes in PCI, albeit at the expense of major bleeding. Major bleeding complications are amongst the most common to occur following PCI, with varying incident rates reported due to different definitions of what constitutes a ‘major bleeding event following PCI’, and the risk profile of the patients studied. Irrespective of the bleeding definition used, major bleeding events universally lead to a worse outcome. Major bleeds can occur at both the access site used for PCI and non-access site sources. Both access site and non-access site bleeding increase mortality following PCI. Patients who undergo PCI are at an increased risk of bleeding for several years following the procedure. Strategies to reduce the risk of bleeding should focus on pharmacotherapy, and importantly, use a radial rather than femoral approach to perform PCI.
Ageing in Chronic Kidney Disease
Authors: Stannard Robin
Published: January 2023

DAY 4 of the 59th ERA Congress 2022 included an expert session on cellular ageing. In a symposium session featuring specialist insight from researchers in the field, discussions focused on the cellular processes that contribute to aging, environmental influences that correlate with ageing phenotype, and chronic kidney disease (CKD) as a model for dysregulated ageing. Exploring treatments and lifestyle changes that slow ageing and increase health span, experts also shared research underlining the importance of the microbiome and the role dysbiosis plays in triggering age-related pathways.
Advances in the Management of Transient Ischaemic Attack and Stroke
Authors: Montalvo Mayra J , Siket Matthew S. , Jayaraman Mahesh V. , Yaghi Shadi , Silver Brian
Published: January 2023

Among many important advances in the management of transient ischaemic attack (TIA) and stroke are: the updated definition of TIA; risk stratification scores for TIA; the urgent diagnostic and treatment process for TIA; thrombectomy treatment for large vessel occlusive ischaemic stroke; cryptogenic stroke evaluation and treatment, including long-term monitoring for paroxysmal atrial fibrillation; and strategies to improve outcomes for patients including mirror therapy for neglect and timing of mobilisation after stroke. Future research will focus on: antiplatelet strategies after TIA; selecting patients for treatment with recanalisation therapies in an extended time window; uncovering the cause of strokes previously defined as cryptogenic; and better defining the optimal timing and dose of mobilisation after stroke.
STRATEGI PENINGKATAN KUALITAS PELAYANAN PUBLIK DI DINAS DUKCAPIL DAN KANTOR PERTANAHAN KOTA TANGERANG
Authors: Utami Pri
Published: January 2023

Penelitian ini di latar belakangi oleh kondisi penyelenggaraan pelayanan publik yang kurang efektif dan efisien, dimana organisasi pemerintah masih banyak mengidap penyakit-penyakit birokrasi yang dicirikan dengan lebih menekankan proses dari pada tujuan, selain itu pelayanan yang diberikan hanya kepada kedekatan hubungan sehingga masyarakat mengeluhkan proses pelayanan tersebut lebih banyak menyulitkan dari pada mempermudah. Beragam keluhan dan ketidakpuasan masyarakat terhadap pelayanan publik menunjukan suatu harapan agar perubahan kinerja pegawai pemerintah mampu kearah yang lebih baik. Pelayanan publik merupakan bentuk pelayanan yang di berikan pemerintah untuk masyarakat yang membutuhkan pengurusan administrasi. Salah satu pelayanan yang dibuat oleh pemerintah yaitu pada Dinas Pertanahan adalah pendaftaran tanah, sedangkan pada Dinas Kependudukan dan Pencatatan Sipil yaitu pembuatan Akta Kelahiran. Akta kelahiran merupakan bentuk identitas seorang anak yang menjadi bagian yang tidak terpisahkan dari hak sipil dan politik warga negara.akta kelahiran bukan hanya sekedar selembar  kertas tapi juga digunakan untuk melamar kerja, sekolah dan sebagai bentuk pengakuan status kewarganegaraan seseorang dan identitas serta bukti pemberian pelayanan public.

Kata kunci : Pelayanan Publik, Pemerintah, Kinerja Pegawai
TEACHER DEVELOPMENT INTENSITY AND RESPONSIBILITY WITH PERFORMANCE IN SENIOR HIGH SCHOOL
Authors: Galuh Iman Rais Juliawan , Mulyanto Agus Iwan
Published: January 2023

Teacher performance affects the intensity relationship between teacher job satisfaction, organizational culture, teacher responsibility, and the intensity of coaching and teacher welfare from the principal. The aim is to see the intensity of coaching and responsibility with the productivity of teacher performance. The research method used in this study is the Crocoational Survey which is associative of the relationship between two or more variables. The data used is quantitative data, namely numerical data in statistical counts that are collected through a research questionnaire from a number of respondents. Validity test such as (a). Classical Assumption Test (b). Hypothesis Test (c). Multiple Linear Regression (d). Correlation Coefficient Test (e). Determination Coefficient Test Conclusion: There is a positive and significant relationship between the coaching intensity variable and teacher performance, and a significant positive relationship between the responsibility variable and the teacher performance variable, as well as a positive and significant relationship between the coaching intensity variable and the responsibility variable with the teacher performance variable.

 

Keywords : Intensity Relationship, Teacher Development, Responsibility, Performance
Mültecilerde Sağlık Hizmetlerine Erişim
Authors: ALTINDİŞ Selma , İNCİ Mustafa Baran , ERKORKMAZ Ünal
Published: January 2023

Amaç: Bu çalışma Sakarya’da yaşayan Suriye ve Irak kökenli göçmenlere sağlık hizmetlerine erişim durumunun ve erişimin önündeki engellerin belirlenmesi amacıyla yapıldı.

Gereç ve Yöntemler: Sakarya’da Ekim 2017-Ekim 2018 arasında yürütüldü. Araştırmanın evrenini Sakarya’da yaşayan Suriyeli ve Iraklı yabancı nüfus oluşturdu. Çalışmanın ilk bölümü için olasılıksız örnekleme yöntemlerinden uygun (convenience) örnekleme yöntemiyle 500 kişi çalışmaya alındı. Göçmenlerin çokça ziyaret ettiği yerlerde Arapça ve Türkçe konuşabilen anketörler görevlendirildi. Veriler yüz yüze görüşme yöntemiyle toplandı. Araştırmanın nitel kısmında Arapça ve Türkçe bilen çevirmenler yüz yüze mülakat tekniğiyle 50 kişiden sağlık kurumlarına erişimde yaşadıkları sorunlarla ilgili deneyimler ve düşünceler elde etti. Ek olarak göçmenlerin hastane/polikliniklerde yaşadıkları sorunlar için gözlem tekniğiyle 50 saatlik gözlem yapıldı ve gözlem formları dolduruldu.

Bulgular: Katılımcıların %51,40’ü Iraklı, %48,60’sı Suriyeliydi. Katılımcıların %50,60’sı kadın; genel yaş ortalaması 35,90±11,30 (17,00-72,00) yıldı. Katılımcıların %65,60’sı sağlık sistemi işleyişini öğrenmekte sorun yaşadığını, %71,40’ü sağlık kuruluşlarındaki bilgilendirme yazılarıyla tabelalarını anlayamadıklarını, %81,20’si randevu alma sorunları olduğunu, %77,80’i hekimle tanı/tedavileri konusunda anlaşamadığını ve %51,40’ü ise eczanede ilaç temini sırasında alınan ilacın kullanımına ilişkin sorun yaşadığını bildirdi. Çalışmanın ikinci bölümünde; katılımcıların çoğunluğu muayene için randevu almakta zorluk yaşadıklarını, bilgilendirme yazılarıyla tabelaları anlamakta zorluk çektiklerini, eczanelerde dil engeli yaşadıklarını belirtti. Araştırmanın üçüncü bölümünde Sakarya Üniversitesi Eğitim ve Araştırma Hastanesinde yapılan gözlemlerde en sık karşılaşılan talepler hastane bölümlerinin yerlerini sorma ve yönlendirme talepleriydi.

Sonuç: Göçmenlerin sağlık hizmeti alımı esnasında yaşadıkları dil kaynaklı iletişim sorunlarının ve bunlardan kaynaklanan olumsuzlukların önüne geçmek için sağlık kuruluşlarında dil bariyerini aşmaya yönelik hem insan gücü yönünden hem de fiziki anlamda düzenlemeler yapılmalıdır.
Classification of Middle-aged Women's Body Types for 3D Avatar Modeling
Authors:   The Korean Society of Culture and Convergence, Yoon Jiwon , Hong Eunhee
Published: January 2023

This study aims to provide basic data that can be used for 3D avatar modeling by categorizing the body type of middle-aged women aged 40-59 according to their shape and analyzing their characteristics. This study was sampled with 3D body scanned data to 522 middle-aged women provided by the ‘Size Korea 8th Body Size Survey’. Factors for body type classification contained arm and lower body horizontal size, body vertical size, hip length, neck·shoulder size, torso flatness, shoulder·armpit shape, upper body shape, horizontal armpit size, upper body lateral shape, breast Size, belly size, front and back width difference, and head size. The survey was found to be body typed with development of lower body with long limbs, a flat body without curvature, development of a curved upper body, and a bent body with a belly protruding.
Application of Mentoring Program for Effective Operation of Cooperative Learning
Authors:   The Korean Society of Culture and Convergence, Nam Hyewon
Published: January 2023

The purpose of this study is to apply a mentoring program to classes designed based on cooperative learning, to analyze changes in students' academic achievement and learners' mathematical attitudes, and to confirm the applicability of extracurricular activity programs. For this study, the basic academic ability evaluation and midterm test scores of 'Mathematics (1)' students are analyzed to form small groups, and the small groups solve tasks centered on mentors nurtured through the 'Mathematics Mentoring' program. As a result of the study, it was confirmed that the application of the mentoring program helped improve academic achievement and strengthen core competencies, and especially helped improve learning satisfaction by increasing class participation and concentration of students with insufficient basic academic ability.
The Popularity of the Sukhyangjeon Narrative and its Literary Significance
Authors:   The Korean Society of Culture and Convergence, Kim Miryeong
Published: January 2023

This study focused on the popularity of  and tried to examine the literary meaning of . This is because 'popularity' shows the 'philosophy of the times' and at the same time shows what kind of sentiment and worldview prevail among the silent majority.  has repeated readers' tension and relaxation through narrative strategies to gain popularity. In addition, it contains a dual message that implies both the superficial theme that makes the reader conform to the existing conventions and the hidden theme that reverses the ideology and gender issues of the contemporary society.
A Study on the Role of Masks and Make-up in the Movie Titled
Authors:   The Korean Society of Culture and Convergence, Chen Kun , Han Kyunghoon
Published: January 2023

Purpose the present study attempted to explore the movie  as a research topic with the coverage of extensive social issues, and explores how masks and make-up are used in the film. The researcher adopted Masashiro’s Uncanny Valley, Semiotics from Saussure, and Fred’s psychoanalysis to analyze implicit meanings derived from masks and make-up. This paper showed that masks help elicit the inherent and explicit characteristics of Cho-hee, a leading actress in the Movie. This character depicts a detailed and overall image of the protagonist. In addition, make-up displays how the implicit personality of the main actor, Tae-in, has changed. It helps us understand the direction of Tae-in's inner. On the surface, the meaning of hope for the world was derived from a new perspective. Moreover, the research explores social issues associated with socialism in multiple ways to identify and demonstrate class discrimination, the gap between the rich and the poor, and the predominance of men over women shown in the Movie.
A Study on the Types of Perceptions of Education For Social Responsibility
Authors:   The Korean Society of Culture and Convergence, Kim Eunji
Published: January 2023

The purpose of this study was to investigate the types of education for social responsibility. To achieve this a Q-methodological analysis was used to study people’s subjectivity in individual perceptions and beliefs. The Q-population was composed of 41 questions based on literature analysis, a pre-survey, and in-depth interviews. Q-samples were finally composed of 31 statements after expert reviewing. Thirty-four students majoring in education at P graduate school participated in this study. Q-sorting was performed for two weeks in October 2022, and the data were analyzed through the PQ Method 2.35 program. The analysis was based on the most positive and negative statements, and identification items. Education for social responsibility was classified into three types: Emphasis on concept understanding and field practice, Emphasis on state intervention and personal growth, and Emphasis on research and edaucator role. By examining the perception types of students who accept the concept of education for social responsibility, it will be possible to prepare action plans for including social responsibility in education.
A Study on Creativity as Mature Narcissism for ‘Creative Ageing’ : Focusing on Heinz Kohut's Self Psychology
Authors:   The Korean Society of Culture and Convergence, Lee Jungmin
Published: January 2023

The purpose of this study is to find out about creativity, a mature and healthy variant of narcissism, claimed by Heinz Kohut's Self Psychology, and to lay the theoretical basis for the psychological driving force behind the life of “creative aging” in old age. To this end, literature research was mainly conducted based on related books and papers, and through the case analysis of the elderly in Korea, how creativity as a mature narcissism can be realized as a “creative aging” life was examined. Based on Kohut's theory of self psychology, the study shows that old age can realize the life of “creative aging” by demonstrating creativity, a transformation of mature narcissism, through everyday experiences such as culture and arts education, and developing life and thoughts creatively. To this end, a wide cultural and artistic educational environment that can promote creativity and 'creative aging' should be established.
Peran Kader Juru Pamantau Jentik (Jumantik) Mandiri dalam Upaya Pencegahan Penyakit DBD di Kelurahan Talise Valangguni Kota Palu
Authors: Syam Dedi Mahyudin , Aryanti Ros , Christine Christine
Published: January 2023

Efforts to prevent and control dengue fever in Palu City are still inadequate, the results of a survey carried out by officers show that community participation in eradicating mosquito nests (PSN), especially in closing, draining and burying (3M) and plus (plus) activities such as: sprinkling larvacide larvae, keeping larvae-eating fish. This effort involves larva monitoring interpreters (jumantik) but the role of independent jumantik is not yet optimal. This is indicated by the larva free rate which is still below the standard of 85%. The target of this community service activity is the Jumantik Mandiri Cadre at Citra Permai Indah 3 Complex (CPI3) in Talise Valangguni Village, Palu City, totaling 25 people. The method used is lecture and question and answer. Lectures were conducted to disseminate information on dengue prevention, how to monitor larvae and field practice in the form of larva monitoring in the CPI3 housing complex. The activity was carried out from May to June 2022 at the CPI-3 housing complex, Talise Valangguni Village, Palu City. The results of the activity show the role of the independent Jumantik Cadre. After receiving education and guidance from the service team, it increased up to 100% and the larva-free rate (ABJ) in monitoring from the first week-1 to week-3 always increased up to 98%. Providing education can increase the role of independent jumantik cadres and effectively increase the larva free rate.
ABSTRAK
Upaya pencegahan dan pengendalian penyakit DBD di Kota Palu masih belum memadai, hasil survei yang telah dilaksanakan oleh petugas, menunjukkan bahwa partisipasi masyarakat dalam pemberantasan sarang nyamuk (PSN)  terutama dalam kegiatan menutup, menguras dan mengubur  (3M) dan ditambah (plus) seperti: menaburkan larvasida pembasmi jentik, memelihara ikan pemakan jentik. Upaya ini melibatkan juru pemantau jentik (jumantik) namun peran jumantik mandiri belum optimal. Hal tersebut ditandai dengan Angka Bebas Jentik masih dibawah standar 85%. Sasaran kegiatan pengabdian kepada masyarakat ini adalah Kader Jumantik Mandiri Komplek Citra Permai Indah 3 (CPI3) Di Kelurahan Talise Valangguni Kota palu berjumlah 25 orang. Metode yang digunakan adalah ceramah dan tanya jawab. Ceramah dilakukan untuk mensosialisasikan informasi tentang, Pencegahan DBD, cara melakukan monitoring jentik dan praktek lapangan berupa pemantauan jentik di komplek perumahan CPI3. Kegiatan dilaksanakan  Mei – Juni 2022 Di Komplek perumahan CPI-3 Kelurahan Talise Valangguni Kota palu. Hasil kegiatan menunjukkan Peran Kader Jumantik Mandiri Setelah memperoleh edukasi dan bimbingan dari tim pengabdi mengalami peningkatan hingga 100% serta Angka Bebas Jentik (ABJ) dalam pemantauan mulai dari minggu-1 pertama sampai minggu-3 selalu mengalami peningkatan hingga mencapai 98%.Pemberian edukasi dapat meningkatkan peran kader jumantik mandiri serta efektif meningkatkan Angka bebas Jentik.
Pelayanan Informasi dan Edukasi Tentang Cara Kerja Obat Melalui Media Sosial Instagram
Authors: Sianipar Erlia Anggrainy , Arrang Sherly Tandi , Cokro Fonny
Published: January 2023

The limited knowledge of community regarding drugs is still become a root cause in irrationality treatment. Information and education services about drug action is an important thing that should be known by the community as drug consumers so the rational treatment will be realized and misuse and errors in using drugs can be avoided. The aims of this program are to increase public knowledge about drug action and to find out the most favourite educational topic. Education is provided through the Instagram social media account @pioheal.fkikuaj which is easily accessible by social media users. Knowledge is presented on e-flyer and posted once a week for eight consecutive weeks from May to July 2021. The activities were evaluated through a questionnaire by the e-flyer readers. The results showed that 100% of the readers stated that their knowledge had increased after reading the e-flyer with an average increase ranging from 50-75% and as many as 80% of readers get a score of 70-100 (good). The most favorite educational topic was the drug action on the autonomic nervous system. Based on these results, we concluded that this information and educational services have succeeded in increasing the knowledge of social media users, especially about how drugs work. However, the evaluation of behavioral changes in the community regarding rational drug use needs further investigation.
ABSTRAK
Keterbatasan pengetahuan masyarakat terkait obat masih menjadi akar masalah dalam ketidakrasionalan pengobatan. Pelayanan informasi dan edukasi tentang cara kerja obat merupakan hal penting yang hendaknya diketahui oleh masyarakat sebagai konsumen obat sehingga pengobatan yang rasional dapat terwujud dan penyalahgunaan serta penggunaan yang salah terhadap obat dapat dihindari. Tujuan kegiatan ini adalah untuk meningkatkan pengetahuan masyarakat tentang cara kerja obat dan mengetahui topik edukasi yang paling diminati.  Pemberian edukasi dilakukan melalui akun media sosial Instagram @pioheal.fkikuaj yang mudah diakses oleh para pengguna media sosial. Pengetahuan disajikan dalam bentuk e-flyer dan diposting setiap satu minggu sekali selama delapan minggu berturut-turut mulai pada bulan Mei hingga bulan Juli 2021. Kegiatan dievaluasi melalui kuesioner oleh pembaca e-flyer. Hasil kuesioner menunjukkan bahwa 100% pembaca menyatakan pengetahuannya meningkat setelah membaca e-flyer dengan rata-rata peningkatan berkisar antara 50-75% dan sebanyak 80% pembaca mendapatkan nilai 70-100 (baik).  Topik edukasi yang paling diminati adalah tentang obat-obat yang bekerja pada sistem saraf otonom. Berdasarkan hasil tersebut, kami menyimpulkan bahwa pelayanan informasi dan edukasi ini berhasil meningkatkan pengetahuan pengguna media sosial terutama mengenai cara kerja obat. Namun, evaluasi terhadap perubahan perilaku di masyarakat terkait penggunaan obat yang rasional perlu diteliti lebih lanjut.
Empowerment of the Indonesian Red Cross Organization (IRCO) as a Convenience of Knowledge Healthy and Clean-Living Behavior (HCLB) during the Covid-19 Pandemic in the School through Graphic Design Media
Authors: Jayadi Yusma Indah , Adha A. Syamsiah , Tompo Nurul Inayah , Utami Nur Intan , Yudianti Anita
Published: January 2023

he impact of the lack of Clean and Healthy Living Behavior (HCLB) is a learning atmosphere that is less comfortable due to a dirty environment, lowers enthusiasm for learning, and reduces the good image of the school in the general public. Diseases that occur in school-age children such as diarrhea, intestinal worms, anemia, dengue fever are related to Clean and Healthy Living Behavior. This community empowerment program aims to provide information with the aim of increasing knowledge about clean and healthy living behavior (HCLB) through graphic design media during the COVID 19 pandemic. Theain material for this training was an overview of HCLB in general and HCLB that is more specific in school settings during the COVID 19 pandemic, as well as showing examples of graphic design to practice skills as an educational medium. The program targets were members of IRCO MAN 2 Makassar City. The first activity, namely the empowerment team from UIN Alauddin Makassar, first conducted a problem analysis by making IRCO members as partners. The second activity was advocacy by conducting program presentations, getting support from the school, their willingness to work together, and sharing team work with partners. The third activity, namely building an atmosphere, which was carried out by training and mentoring partners to become cadres, will be held on March 8-9, 2022. Assistance in making graphic designs on March 10, 2022. The number of students who were trained were 12 students who were members of IRCO as prospective peer counselors with the paired sample t-test, a 2-tailed significance value of 0.013 < 0.05, indicating a significant difference in pre- and post-test knowledge. The last activity is a community movement which is carried out in the form of implementing the previous peer educator training. The results obtained from 36 peer participants using the Wilcoxon test, known as Asymp.Sig. (2-tailed) is worth 0.000< 0.05. The results show that there is an effect of implementing empowerment on cadres and peers regarding HCLB in the school setting.
Upaya Peningkatan Imunitas Tubuh melalui Edukasi Pangan dan Gizi bagi Pegawai dan Dosen di LLDIKTI Wilayah VIII
Authors: Kusumawati I Gusti Ayu Wita , Nursini Ni Wayan , Yogeswara Ida Bagus Agung , Sulistyadewi Ni Putu Eny , Puspaningrum Dylla Hanggaeni Dyah , Wiradnyani Ni Ketut , Mantra Ida Bagus Ketut , Kusumaningsih Purwaningtyas , Mustika I Gede
Published: January 2023

The Covid 19 pandemic and unhealthy life style may lead to depression and anxiety followed by a decreasing of immune system. A healthy diet affects a person’s health and immune system. Objective: To provide education to the community, especially employees and lecturers in the LLDIKTI region VIII work environment, regarding food consumption and nutrition that can prevent stress and increase endurance during a pandemic. Methods: The activity begins with preparation, implementation and evaluation. Education is carried out using virtual media through zoom meetings, which are in the form of webinar series containing lectures and discussions. At the beginning of the activity, partners are given a pre-test and at the end of the discussion partners are given a post-test. Community service activities are carried out from October 13, 2021, to November 13, 2021. The evaluation was carried out using a knowledge questionnaire based on the material presented by the speaker.  The results of the community service activities showed an increase in partner knowledge about food and nutrition consumption that can prevent stress and increase endurance during a pandemic. Suggestion: It is necessary to conduct training and assistance in hygiene food processing to produce processed innovations that can be used to increase body immunity.
Pelatihan Penyusunan Uraian Tugas pada Pegawai Rumah Sakit Milik Pemerintah Provinsi Sulawesi Selatan
Authors: Sidin Andi Indahwaty , Arifah Nur , Sari Nurmala , Kalsum Ummu
Published: January 2023

The job description is an important element in performance management. The performance achievements of hospitals owned by the South Sulawesi provincial government in the last 3 years have shown less than optimal results. To improve the performance of the hospital, it is necessary to redesign the current job description. This activity aims to improve comprehensive knowledge and skills regarding the preparation of job descriptions for performance improvement in government hospitals belonging to the province of South Sulawesi. The training participants were 21 employees from 7 hospitals owned by the South Sulawesi Provincial Government. The method used is the provision of education in the form of lectures, discussions, group assignments, and presentations. The results of the evaluation found that the average level of knowledge of participants before the training was only 2.38 and then increased to 5.19 after the training. In addition, after the training, the participants have been able to review and compile their job descriptions in the hospital. It is hoped that this training can become a training of trainers so that those who have completed the training can become presenters to train other employees where they work.
Decellularized vascularized bone grafts: A preliminary in vitro porcine model for bioengineered transplantable bone shafts
Authors: Rougier Guillaume , Maistriaux Louis , Fievé Lies , Xhema Daela , Evrard Robin , Manon Julie , Olszewski Raphael , Szmytka Fabien , Thurieau Nicolas , Boisson Jean , Kadlub Natacha , Gianello Pierre , Behets Catherine , Lengelé Benoît
Published: January 2023

Introduction: Durable reconstruction of critical size bone defects is still a surgical challenge despite the availability of numerous autologous and substitute bone options. In this paper, we have investigated the possibility of creating a living bone allograft, using the perfusion/decellularization/recellularization (PDR) technique, which was applied to an original model of vascularized porcine bone graft.

Materials and Methods: 11 porcine bone forelimbs, including radius and ulna, were harvested along with their vasculature including the interosseous artery and then decellularized using a sequential detergent perfusion protocol. Cellular clearance, vasculature, extracellular matrix (ECM), and preservation of biomechanical properties were evaluated. The cytocompatibility and in vitro osteoinductive potential of acellular extracellular matrix were studied by static seeding of NIH-3T3 cells and porcine adipose mesenchymal stem cells (pAMSC), respectively.

Results: The vascularized bone grafts were successfully decellularized, with an excellent preservation of the 3D morphology and ECM microarchitecture. Measurements of DNA and ECM components revealed complete cellular clearance and preservation of ECM’s major proteins. Bone mineral density (BMD) acquisitions revealed a slight, yet non-significant, decrease after decellularization, while biomechanical testing was unmodified. Cone beam computed tomography (CBCT) acquisitions after vascular injection of barium sulphate confirmed the preservation of the vascular network throughout the whole graft. The non-toxicity of the scaffold was proven by the very low amount of residual sodium dodecyl sulfate (SDS) in the ECM and confirmed by the high live/dead ratio of fibroblasts seeded on periosteum and bone ECM-grafts after 3, 7, and 16 days of culture. Moreover, cell proliferation tests showed a significant multiplication of seeded cell populations at the same endpoints. Lastly, the differentiation study using pAMSC confirmed the ECM graft’s potential to promote osteogenic differentiation. An osteoid-like deposition occurred when pAMSC were cultured on bone ECM in both proliferative and osteogenic differentiation media.

Conclusion: Fully decellularized bone grafts can be obtained by perfusion decellularization, thereby preserving ECM architecture and their vascular network, while promoting cell growth and differentiation. These vascularized decellularized bone shaft allografts thus present a true potential for future in vivo reimplantation. Therefore, they may offer new perspectives for repairing large bone defects and for bone tissue engineering.
Development of a dual-component infection-resistant arterial replacement for small-caliber reconstructions: A proof-of-concept study
Authors: Zia Sonia , Djalali-Cuevas Adrian , Pflaum Michael , Hegermann Jan , Dipresa Daniele , Kalozoumis Panagiotis , Kouvaka Artemis , Burgwitz Karin , Andriopoulou Sofia , Repanas Alexandros , Will Fabian , Grote Karsten , Schrimpf Claudia , Toumpaniari Sotiria , Mueller Marc , Glasmacher Birgit , Haverich Axel , Morticelli Lucrezia , Korossis Sotirios
Published: January 2023

Introduction: Synthetic vascular grafts perform poorly in small-caliber (<6mm) anastomoses, due to intimal hyperplasia and thrombosis, whereas homografts are associated with limited availability and immunogenicity, and bioprostheses are prone to aneurysmal degeneration and calcification. Infection is another important limitation with vascular grafting. This study developed a dual-component graft for small-caliber reconstructions, comprising a decellularized tibial artery scaffold and an antibiotic-releasing, electrospun polycaprolactone (PCL)/polyethylene glycol (PEG) blend sleeve.

Methods: The study investigated the effect of nucleases, as part of the decellularization technique, and two sterilization methods (peracetic acid and γ-irradiation), on the scaffold’s biological and biomechanical integrity. It also investigated the effect of different PCL/PEG ratios on the antimicrobial, biological and biomechanical properties of the sleeves. Tibial arteries were decellularized using Triton X-100 and sodium-dodecyl-sulfate.

Results: The scaffolds retained the general native histoarchitecture and biomechanics but were depleted of glycosaminoglycans. Sterilization with peracetic acid depleted collagen IV and produced ultrastructural changes in the collagen and elastic fibers. The two PCL/PEG ratios used (150:50 and 100:50) demonstrated differences in the structural, biomechanical and antimicrobial properties of the sleeves. Differences in the antimicrobial activity were also found between sleeves fabricated with antibiotics supplemented in the electrospinning solution, and sleeves soaked in antibiotics.

Discussion: The study demonstrated the feasibility of fabricating a dual-component small-caliber graft, comprising a scaffold with sufficient biological and biomechanical functionality, and an electrospun PCL/PEG sleeve with tailored biomechanics and antibiotic release.
A bibliometric analysis of the application of stem cells in glaucoma research from 1999 to 2022
Authors: Tao Yuanyuan , Zhang Qian , Meng Ming , Huang Jufang
Published: January 2023

Background: Glaucoma, a neurodegenerative disease of the retina, is the leading cause of irreversible blindness. Stem cells have therapeutic potential for glaucoma. However, few bibliometric studies have been published in this field. Concerning a visual map, this article aims to characterize the research context, cooperation relationship, hotspots, and trends concerning the application of stem cells in glaucoma research.

Methods: Publications focusing on stem cell research and glaucoma were retrieved from the Web of Science Core Collection. VOSviewer, CiteSpace, Microsoft Excel, and Scimago Graphica were used to map the contributions of countries or regions, authors, organizations, and journals. Journal Impact Factor data were obtained from the Web of Science Core Collection. We analyzed the tendencies, hotspots, and knowledge networks using VOSviewer, and CiteSpace.

Results: We analyzed 518 articles published from 1999 through 2022. In the first decade, the number of articles in this field increased slowly, and there was a marked acceleration in publication frequency after 2010. The United States, China, and England were the main contributors. Yiqin Du was the most prolific author, and among the top 10 prolific writers, Keith R. Martin’s work was cited most frequently. Investigative Ophthalmology and Visual Science, Experimental Eye Research, and Cornea published the most articles in this domain. The three most commonly co-cited journals were Investigative Ophthalmology and Visual Science, Experimental Eye Research, and Proceedings of the National Academy of Sciences of the United States of America. The Central South University, the University of Pittsburgh, and the National Institutes of Health National Eye Institute were highly prolific institutions in this research area. Our keywords analysis with VOSviewer suggested directions of future research and yielded the following recent key themes, extracellular vesicles, exosomes, mitochondria, growth factors, oxidative stress, and ocular diseases. Four co-cited references had a citation burst duration until 2022.

Conclusion: With improvements in overall quality of life and demographic transitions toward population aging, research and clinical focus on eye care has increased, with glaucoma as a key area of emphasis. This study added to our understanding of the global landscape and Frontier hotspots in this field.
The association of the paraoxonase 1 Q192R polymorphism with coronary artery disease (CAD) and cardiometabolic risk factors in Iranian patients suspected of CAD
Authors: Darand Mina , Salehi-Abargouei Amin , Vahidi Mehrjardi Mohammad Yahya , Feizi Awat , Seyedhossaini Seyed Mustafa , Askari Gholamreza
Published: January 2023

Introduction

The present study aimed to investigate the association of the paraoxonase 1 (PON1) Q192R polymorphism with coronary artery disease (CAD) and cardiometabolic risk factors in Iranian patients suspected of CAD.

Methods

This cross-sectional study was conducted on 428 patients undergoing angiography. The data related to demographic information and physical activity were collected by valid and reliable questionnaires. The PON-1 genotypes were detected by the polymerase chain reaction-restriction fragment length polymorphism (RFLP-PCR) technique. The Gensini and SYNTAX score, anthropometric measurements, and biochemical and clinical parameters were measured by standard protocols.

Results and discussion

Findings indicated that the odds of obesity was significantly higher in people with the RR genotype compared to the QQ genotype carriers (OR: 2.95 CI: 1.25–6.93, P = 0.014) and also odds of low high-density lipoprotein cholesterol (HDL-C) was marginally higher (OR: 2.31 CI: 0.97–5.49, P = 0.056). There was no significant association between other CAD risk factors with PON1 Q192R polymorphism (P > 0.05). Further analysis showed a significant interaction between sex and 192QR (P = 0.019) and 192 RR (P = 0.007) genotypes on body mass index (BMI). More specifically, the risk of obesity in men carrying the RR genotype was 3.38 times (OR: 3.38 CI: 1.08–10.58, P = 0.036). Also, a significant joint effect of the RR genotype and sex on HDL-C was seen (P = 0.003). The stratification based on sex showed that the risk of low HDL-C is significantly higher in women carrying the RR genotype (OR: 6.18 CI: 1.21–31.46, P = 0.028). A marginal sex-genotype interaction was also found in the risk of elevated alanine aminotransferase (ALT) (P = 0.057). In summary, the findings showed that the risk of obesity and low HDL-C was higher in people carrying the RR genotype. On the other hand, a Q192R polymorphism-sex interaction was observed on the risk of obesity, elevated ALT, and low HDL-C.
A small erythropoietin derived non-hematopoietic peptide reduces cardiac inflammation, attenuates age associated declines in heart function and prolongs healthspan
Authors: Winicki Nolan M. , Nanavati Alay P. , Morrell Christopher H. , Moen Jack M. , Axsom Jessie E. , Krawczyk Melissa , Petrashevskaya Natalia N. , Beyman Max G. , Ramirez Christopher , Alfaras Irene , Mitchell Sarah J. , Juhaszova Magdalena , Riordon Daniel R. , Wang Mingyi , Zhang Jing , Cerami Anthony , Brines Michael , Sollott Steven J. , de Cabo Rafael , Lakatta Edward G.
Published: January 2023

Background

Aging is associated with increased levels of reactive oxygen species and inflammation that disrupt proteostasis and mitochondrial function and leads to organism-wide frailty later in life. ARA290 (cibinetide), an 11-aa non-hematopoietic peptide sequence within the cardioprotective domain of erythropoietin, mediates tissue protection by reducing inflammation and fibrosis. Age-associated cardiac inflammation is linked to structural and functional changes in the heart, including mitochondrial dysfunction, impaired proteostasis, hypertrophic cardiac remodeling, and contractile dysfunction. Can ARA290 ameliorate these age-associated cardiac changes and the severity of frailty in advanced age?

Methods

We conducted an integrated longitudinal (n = 48) and cross-sectional (n = 144) 15 months randomized controlled trial in which 18-month-old Fischer 344 x Brown Norway rats were randomly assigned to either receive chronic ARA290 treatment or saline. Serial echocardiography, tail blood pressure and body weight were evaluated repeatedly at 4-month intervals. A frailty index was calculated at the final timepoint (33 months of age). Tissues were harvested at 4-month intervals to define inflammatory markers and left ventricular tissue remodeling. Mitochondrial and myocardial cell health was assessed in isolated left ventricular myocytes. Kaplan–Meier survival curves were established. Mixed ANOVA tests and linear mixed regression analysis were employed to determine the effects of age, treatment, and age-treatment interactions.

Results

Chronic ARA290 treatment mitigated age-related increases in the cardiac non-myocyte to myocyte ratio, infiltrating leukocytes and monocytes, pro-inflammatory cytokines, total NF-κB, and p-NF-κB. Additionally, ARA290 treatment enhanced cardiomyocyte autophagy flux and reduced cellular accumulation of lipofuscin. The cardiomyocyte mitochondrial permeability transition pore response to oxidant stress was desensitized following chronic ARA290 treatment. Concurrently, ARA290 significantly blunted the age-associated elevation in blood pressure and preserved the LV ejection fraction. Finally, ARA290 preserved body weight and significantly reduced other markers of organism-wide frailty at the end of life.

Conclusion

Administration of ARA290 reduces cell and tissue inflammation, mitigates structural and functional changes within the cardiovascular system leading to amelioration of frailty and preserved healthspan.
Quantitative analysis of the risk of hydrogen sulfide release from gas hydrates
Authors: Wang Xianqing , Liu Siqing , Zhao Bin , Yao Yanfu , Wu Gang , Xie Rui , Fu Yutong , Ning Zijie
Published: January 2023

The role that H2S plays in the global sulfur cycle has been studied extensively in recent years. This paper focuses on the influence of H2S released from gas hydrates on sulfur cycle and establishes a one-dimensional mathematical model to calculate the amount of H2S released from the dissociation of gas hydrates present in multiple layers in the Qiongdongnan Basin China. The results show that the sulfate and methane transition zone that covers an area of about 100 km2in the Qiongdongnan Basin contains 2.3 × 1012 g of pyrite, which requires 4.06 × 1011 mol of H2S for its formation. The H2S released from the dissociation of gas hydrates is 5.4 ×1011 mol, which is about 1.3 times that needed for the formation of pyrite. Therefore, the H2S released from the gas hydrates is an important source of H2S for the formation of pyrite in the sulfate-methane transition zone of Qiongdongnan Basin. According to the flux of H2S and the partial pressure of O2 (PO2) in the atmosphere, the critical value of the balance between the flux of H2S and PO2 turns out to be 0.13 mol kg−1∙bar−1. Furthermore, considering the effect of global sea-level changes, three risk modes are identified to categorize the amount of H2S released from the dissociation of gas hydrate into the atmosphere. We classify the periods from 5–12 Ma BP, 25–29 Ma BP, 47–52 Ma, and 57–61 Ma BP into the high-risk mode. Furthermore, the results show that a part of the H2S released from the gas hydrate dissociation is oxidized by the Fe (III) oxide metal, with much of the metal ions being released into the pore water. Another part of the H2S is re-oxidized by the O2 in the ocean, with much of SO42- released into the seawater. Therefore, the process also provides metal ions and SO42- to pore water or seawater when the H2S released from gas hydrate diffuses from the bottom. This paper provides new insights into the source of H2S in the ocean and shows that the H2S contained in gas hydrates plays an important role in the global sulfur cycle.