bluuebunny/crossref_metadata_2025 huggingface dataset:
Dietary behaviours in the context of nutrition transition: a systematic review and meta-analyses in two African countries
Authors: Rousham Emily K , Pradeilles Rebecca , Akparibo Robert , Aryeetey Richmond , Bash Kristin , Booth Andrew , Muthuri Stella K , Osei-Kwasi Hibbah , Marr Colette M , Norris Tom , Holdsworth Michelle
Published: March 2020

Objective:

To synthesise evidence of urban dietary behaviours (macronutrients, types of foods, dietary diversity and dietary practices) in two African countries in relation to postulated changes in the context of nutrition transition.

Design:

Systematic review and meta-analyses, including six online databases and grey literature, 1971–2018 (Protocol CRD42017067718).

Setting:

Urban Ghana and Kenya.

Participants:

Population-based studies of healthy adolescents and adults.

Results:

The forty-seven included studies encompassed 20 726 individuals plus 6526 households. Macronutrients were within WHO-recommended ranges: mean energy intake was 1867 kcal/d (95 % CI 1764, 1969) and the proportions of macronutrients were carbohydrate 61·2 % (58·4, 64·0), fat 25·3 % (22·8, 28·0) and protein 13·7 % (12·3, 15·1). The proportion of population consuming fruit and vegetables was 51·6 %; unhealthy foods, 29·4 %; and sugar-sweetened beverages (SSBs), 39·9 %. Two-thirds (68·8 %) consumed animal-source proteins. Dietary diversity scores were within the mid-range. Meal patterns were structured (typically three meals per day), with evidence lacking on snacking or eating out.

Conclusions:

Population-level diets fell within WHO macronutrient recommendations, were relatively diverse with structured meal patterns, but some indications of nutrition transition were apparent. The proportion of population consuming fruit and vegetables was low compared to healthy-eating recommendations, and consumption of SSBs was widespread. A paucity of evidence from 1971 to 2010 precluded a longitudinal analysis of nutrition transition. Evidence from these two countries indicates which aspects of dietary behaviours may be contributing to increasing overweight/obesity, namely a low proportion of population consuming fruit and vegetables and widespread consumption of SSBs. These are potential targets for promoting healthier diets.
Homemade infant formula recipes may contain harmful ingredients: a quantitative content analysis of blogs
Authors: Davis Sutton A , Knol Linda L , Crowe-White Kristi M , Turner Lori W , McKinley Erin
Published: March 2020

Objective:

When breast-feeding is not possible, commercially made human milk substitute is recommended. Some consumers would prefer to make their own homemade infant formula (HIF) and may seek information on this practice from internet sources. The purpose of the current study was to investigate the content of blogs posting HIF recipes.

Design:

Blog postings were identified through a comprehensive search conducted using the Google search engine and the following search terms along with the term ‘blog’: ‘Make Your Own Baby Formula’, ‘Homemade Baby Formula’, ‘Do It Yourself (DIY) Baby Formula’, ‘DIY Baby Formula’, ‘Baby Formula Recipe’ and ‘All Natural Baby Formula’. A quantitative content analysis of blogs offering recipes for HIF was completed. Blogs that met the inclusion criteria were reviewed for disclaimers, blogger’s credentials, rationale for HIF use, advertisement or sale of recipe ingredients and recipe ingredients.

Setting:

Worldwide Web.

Results:

Fifty-nine blogs, featuring one hundred forty-four recipes, met inclusion criteria. Among reviewed blogs, 33·9 % did not provide a disclaimer stating breast milk is the preferred option, 25·4 % recommended consulting a healthcare professional before using, and 76·3 % and 20·3 % either advertised or sold ingredients or recipe kits, respectively. Credentials of bloggers varied and only seven bloggers identified themselves as ‘nutritionists’. The three most frequently mentioned recipe ingredients were whole raw cow’s milk (24·3 %), raw goat’s milk (23·6 %) and liver (14·5 %).

Conclusions:

Clinicians should be aware of this trend, discuss source of formula with parents, advocate for appropriate infant feeding practices and monitor for side effects.
Young, old, massive: Steps to understanding globular cluster formation
Authors: Harris William E.
Published: March 2020

On observational grounds we now know a huge amount about the characteristics of massive star clusters in galaxies of all types, from the smallest dwarfs to the most massive giants and even into the Intracluster Medium. The old globular clusters (GCs) in particular exhibit a high degree of uniformity across all these environments in their physical properties including scale size, luminosity distribution, metallicity distribution, and age. As survivors of a long period of dynamical evolution, they are “unusual, but not special” among star clusters.

The past few years have seen major advances in theoretical modelling that are starting to reveal how these massive star clusters formed in the early stages of galaxy evolution. Several suites of models point to their emergence in GMCs (Giant Molecular Clouds), which provide the turbulent big reservoirs of gas within which star clusters can be built. At cluster masses ∼105M⊙ and above, clusters form hierarchically through a nearly equal combination of direct gas accretion, and mergers with smaller clusters scattered throughout the GMC. GCs and YMCs (young massive clusters) in this high mass range should therefore be composite systems right from birth. To make such high-mass clusters, host GMCs of ∼107M⊙ are needed, and these are most commonly found in galaxies at redshifts z ≳ 2.
Using Gaia for studying Milky Way star clusters
Authors: Vasiliev Eugene
Published: March 2020

We review the implications of the Gaia Data Release 2 catalogue for studying the dynamics of Milky Way globular clusters, focusing on two separate topics.

The first one is the analysis of the full 6-dimensional phase-space distribution of the entire population of Milky Way globular clusters: their mean proper motions (PM) can be measured with an exquisite precision (down to 0.05 mas yr−1, including systematic errors). Using these data, and a suitable ansatz for the steady-state distribution function (DF) of the cluster population, we then determine simultaneously the best-fit parameters of this DF and the total Milky Way potential. We also discuss possible correlated structures in the space of integrals of motion.

The second topic addresses the internal dynamics of a few dozen of the closest and richest globular clusters, again using the Gaia PM to measure the velocity dispersion and internal rotation, with a proper treatment of spatially correlated systematic errors. Clear rotation signatures are detected in 10 clusters, and a few more show weaker signatures at a level ∼0.05 mas yr−1. PM dispersion profiles can be reliably measured down to 0.1 mas yr−1, and agree well with the line-of-sight velocity dispersion profiles from the literature.
Gaia results for star clusters and dwarf galaxies in the Milky Way
Authors: Massari Davide
Published: March 2020

The second data release of the Gaia mission coupled with ground-based spectroscopic observations has allowed the determination of the orbital parameters for almost all of the Galactic globular clusters, as well as for the known dwarf spheroidal galaxies orbiting the Milky Way. Moreover, it has led to the discovery of dwarf galaxies that were accreted by the Galaxy long ago and that are now completely disrupted. By exploiting their dynamics in combination with the globular clusters age-metallicity relation, we investigated the clusters-to-dwarfs connection. We found that about 60 globulars likely formed in situ, and associated those that were accreted to the dwarf galaxy progenitor they likely formed in.
Stellar-mass Black Holes in Globular Clusters: Dynamical consequences and observational signatures
Authors: Askar Abbas , Giersz Mirek , Arca Sedda Manuel , Askar Ammar , Pasquato Mario , Leveque Agostino
Published: March 2020

Sizeable number of stellar-mass black holes (BHs) in globular clusters (GCs) can strongly influence the dynamical evolution and observational properties of their host cluster. Using results from a large set of numerical simulations, we identify the key ingredients needed to sustain a sizeable population of BHs in GCs up to a Hubble time. We find that while BH natal kick prescriptions are essential in determining the initial retention fraction of BHs in GCs, the long-term survival of BHs is determined by the size, initial central density and half-mass relaxation time of the GC. Simulated GC models that contain many BHs are characterized by relatively low central surface brightness, large half-light and core radii values. We also discuss novel ways to compare simulated results with available observational data to identify GCs that are most likely to contain many BHs.
Light element discontinuities in the globular cluster NGC 6402 (M14)
Authors: Johnson Christian I.
Published: March 2020

NGC 6402 is one of the most massive globular clusters in the Galaxy but until recently little was known about its detailed chemical composition. Interestingly, recent results have shown that NGC 6402 exhibits a paucity of intermediate composition stars that may be indicative of an early termination of star formation. As a result, NGC 6402 may be important for understanding cluster formation and the order in which various stellar populations are born.
Intermediate-Mass Black Holes in binary rich star clusters
Authors: Šubr Ladislav , Fragione Giacomo , Dabringhausen Jörg
Published: March 2020

Three-body interactions of stellar-mass binaries with intermediate mass black holes (IMBHs) in nuclei of globular clusters may produce specific features that may serve as an independent indicator of existence of the IMBHs. By means of direct N-body integrations we follow the dynamical evolution of globular clusters of moderate extension and mass with 50% binary population over a time span of ≍ 0.8 Gyr and compare the cases with and without the primordial binaries as well as with and without the IMBH. We show that (i) presence of the IMBH leads to rapid formation of a density cusp regardless of the initial binary fraction, (ii) binary rich clusters with the IMBH produce high velocity escapers at a rate of ≍ 0.1 Myr−1 and (iii) clusters hosting an IMBH together with high number of binaries form a denser halo of marginally unbound stars than clusters that lack either the IMBH or the binary population.
Detection of White Dwarf companions to Blue Straggler Stars from UVIT observations of M67
Authors: N Sindhu , Subramaniam Annapurni , Geller Aaron M. , Jadhav Vikrant , Knigge Christian , Simunovic Mirko , Leigh Nathan , Shara Michael , Puzia Thomas H.
Published: March 2020

We investigate the old open cluster M67 using ultraviolet photometric data of Ultra-Violet Imaging Telescope in multi-filter far-UV bands. M67, well known for the presence of several blue straggler stars (BSS), has been put to detailed tests to understand their formation pathways. Currently, there are three accepted formation channels: mass transfer due to Roche-lobe overflow in binary systems, stellar mergers either due to dynamical collisions or through coalescence of close binaries. So far, there had not been any confirmed detection of a white dwarf (WD) companion to any of the BSSs in this cluster. Here, we present the detection of WD companions to 5 bright BSSs in M67. The multiwavelength spectral energy distributions covering 0.12 -11.5 μm range, were found to require binary spectral fits for 5 BSSs, consisting of a cool (BSS) and a hot companion. The parameters (Luminosity, Temperature, Radius and Mass) of the hot companions suggest them to be WDs with mass in the range 0.2 - 0.35 M⊙ with Teff ~11000 –24000 K.
Detection of extended Red Clump in the SMC cluster Kron 3
Authors: Nayak P. K. , Subramaniam A. , Subramanian S. , Sahu S. , Mondal C. , Cioni Maria-Rosa L. , Bell C.
Published: March 2020

For the first time, we report the identification of NUV bright red clump (RC) stars and the extension of RC stars over two magnitudes both in color and magnitude axis in NUV vs (NUV – optical) color magnitude diagram. We find that the extension of RC is not due to photometric uncertainties. We suggest that the extension could be an effect of field star contamination. We also suggest that if it is an intrinsic property of the cluster then age and/or metallicity spread within the cluster could be the possible reasons for extended RC.
The properties of nuclear star clusters and their host galaxies
Authors: Seth Anil C. , Neumayer Nadine , Böker Torsten
Published: March 2020

Nuclear star clusters are found at the centers of most galaxies. They are the densest stellar systems in the Universe, and thus have unique and interesting stellar dynamics. We review how common nuclear star clusters are in galaxies of different masses and types, and then discuss the typical properties of NSCs. We close by discussing the formation of NSCs, and how a picture is emerging of different formation mechanisms being dominant in lower and higher mass galaxies.
Brownian motion of supermassive black holes in galaxy cores
Authors: Di Cintio Pierfrancesco , Ciotti Luca , Nipoti Carlo
Published: March 2020

We investigate the dynamics of supermassive black holes (SMBHs) in galactic cores by means of a semi-analytic model based on the Langevin equation, including dynamical friction and stochastic noise accounting for the gravitational interactions with stars. The model is validated against direct N-body simulations of intermediate-mass black holes in stellar clusters where a realistic number of particles is accessible. For the galactic case, we find that the SMBH experiences a Brownian-like motion with a typical displacement from the geometric center of the Galaxy of a few parsecs, for system parameters compatible with M87.
Growth of intermediate mass black holes in first star clusters
Authors: Sakurai Yuya , Yoshida Naoki , Fujii Michiko S.
Published: March 2020

We study runaway stellar collisions in primordial star clusters and formation of intermediate mass black holes (IMBHs). Using cosmological simulations, we identify eight atomic-cooling halos in which the star clusters form. We follow stellar and dark matter (DM) dynamics for 3Myr using hybrid N-body simulations. We find that the runaway stellar collisions occur in all star clusters and IMBHs with masses ∼400–1900M⊙ form. Performing additional N-body simulations, we explore evolutions of the IMBHs in the star clusters for 15 Myr. The IMBH masses grow via stellar tidal disruption events (TDEs) to ∼700–2500 M⊙. The TDE rates are ∼0.3–1.3 Myr−1. DM motions affect the star cluster evolutions and reduce the TDE rates. The IMBHs may subsequently grow to SMBHs by gas supply through galaxy mergers or large-scale gas inflows, or they may remain within or around the clusters.
The Role of “black hole burning” in the evolution of dense star clusters
Authors: Kremer Kyle , Ye Claire S. , Chatterjee Sourav , Rodriguez Carl L. , Rasio Frederic A.
Published: March 2020

As self-gravitating systems, dense star clusters exhibit a natural diffusion of energy from their innermost to outermost regions, leading to a slow and steady contraction of the core until it ultimately collapses under gravity. However, in spite of the natural tendency toward “core collapse,” the globular clusters (GCs) in the Milky Way exhibit a well-observed bimodal distribution in core radii separating the core-collapsed and non-core-collapsed clusters. This suggests an internal energy source is at work, delaying the onset of core collapse in many clusters. Over the past decade, a large amount of work has suggested that stellar black holes (BHs) play a dynamically-significant role in clusters throughout their entire lifetimes. Here we review our latest understanding of BH populations in GCs and demonstrate that, through their dynamical interaction with their host cluster, BHs can naturally explain the distinction between core-collapsed and non-core-collapsed clusters through a process we call “black hole burning.”
Dynamically stable models for galaxies
Authors: Dabringhausen Jörg , Šubr Ladislav , Feldmeier-Krause Anja
Published: March 2020

A popular approach to model galaxies is Schwarzschild’s method. For this method, a grid of sample orbits of stars in an external potential is calculated, and a model for the stellar system is obtained through attributing specific weights to the orbits in a superposition of them. The models created with Schwarzschild’s method can fit many observed properties of the modeled stellar system with high precision. However, systems that are stationary as Schwarzschild models may therefore exhibit a strong time evolution if they are translated into more realistic self-gravitating models. The issue is highlighted with the Galactic center as an example.
Internal kinematics of Globular Clusters: Current state of the art, issues, and what to expect from the future
Authors: Bellini Andrea
Published: March 2020

The advent of the Gaia mission is bringing astrometry to a new renaissance. Although Gaia will make important breakthroughs in many different scientific areas, stars in the crowded central fields of globular clusters (GCs) and at the faint end of the color-magnitude diagram are and will be out of Gaia’s reach. The Hubble Space Telescope (HST) is an excellent astrometric tool that has allowed us to distinguish and measure positions and brightness of faint stars in pencil-beam fields down to the very center of some GCs. Gaia and HST are two wonderful, complementary tools, but are yet far from being able to offer a complete dynamical picture of GCs. There is now great prefiguration for what the next-generation telescopes will be able to do, both ground- and space-based. This document highlights strengths and weaknesses of different facilities at different spatial and spectral regimes.
Interaction of stars hosting planets with Sgr A* black hole
Authors: Davari Nazanin , Capuzzo-Dolcetta Roberto , Spurzem Rainer
Published: March 2020

We present some preliminary results of our ongoing project about planetary systems around S-stars in the vicinity of Sgr A* black hole. Since S-stars might have migrated in the Galactic Centre (GC) from elsewhere, they probably still keep their planetary systems throughout their voyage. In this work, we study the destiny of their putative planetary systems after close interaction with the central black hole of our galaxy.
The relationship between globular cluster parameters and abundance variations
Authors: Nataf David M.
Published: March 2020

We discuss a meta-analysis of the association of abundance variations in globular cluster stars with the present-day stellar mass and metallicity of globular clusters. Using data for 42 globular clusters that are well-sampled from either or both of prior literature studies and the APOGEE survey, we confirm prior findings that increasing aluminum abundance variations in globular clusters are positively correlated with increasing present-day stellar mass or decreasing metallicity. We also demonstrate that the ratio of aluminum abundance variations to either nitrogen abundance variations or sodium abundance variations is itself positively correlated with decreasing metallicity and increasing stellar mass of globular clusters. This suggests that there were at least two non-supernovae chemical polluters that were active in the early universe.
Thirteen facts that you need to know on multiple populations in globular clusters
Authors: Milone Antonino P.
Published: March 2020

I review the methods, mostly developed in the last decade, that are commonly used to identify and characterize multiple populations (MPs) in Globular Clusters (GCs) based on photometry. I summarize the results from the recent surveys of MPs with the Hubble Space Telescope (HST) and ground-based facilities and provide a list of the main properties of MPs as inferred from these studies.
Alternating direction method of multiplier for solving electromagnetic inverse scattering problems
Authors: Liu Jian , Zhou Huilin , Chen Liangbing , Ouyang Tao
Published: March 2020

In this paper, a novel alternating direction method of multiplier (ADMM) is proposed to solve the inverse scattering problems. The proposed method is suitable for a wide range of applications with electromagnetic detection. In order to solve the internal ill-posed problem of the integral equation and make the reconstructed images more closer to the ground truth, first, the augmented Lagrangian method is introduced to transform the complex constrained optimization problem into the extremum problem of unconstrained cost function. Therefore, two artificial regularization factors of the cost function are optimized. Then, this proposed method decomposes the unconstrained global problem in the inversion process into three linear sub-problem forms of contrast source function, contrast function, and dual variables. And the form of the updated algebra for each sub-problem is not complicated. By cross-iterating and updating contrast source function, contrast function, and dual variables, the global minimization of the cost function can be accurately found. Finally, the proposed method is compared with the existing well-known iterative method for solving the inverse scattering problem. Both the numerical and experimental tests verify the validity and accuracy of the proposed ADMM.
A flexible broadband antenna for IoT applications
Authors: Al-Sehemi Abdullah , Al-Ghamdi Ahmed , Dishovsky Nikolay , Atanasova Gabriela , Atanasov Nikolay
Published: March 2020

A flexible broadband antenna with high radiation efficiency for the Internet of Things (IoT) applications is presented. The design is based on a U-shaped and a triangular-shaped radiator with two tuning stubs. A 50 Ω coplanar waveguide (CPW) transmission line is employed to feed the antenna. The proposed antenna is fabricated on a flexible substrate from a composite synthesized by mixing natural rubber with SiO2 as a filler. The radiating elements, along with the CPW, are built using a highly conductive woven fabric. Results show that the antenna has a simulated and measured impedance bandwidth of 0.856–2.513 GHz and covers the most commonly used wireless communication standards and technologies for IoT applications. The radiation efficiency of the antenna reaches over 75% throughout the operating frequency band with satisfactory radiation patterns and gain. The flexible antenna was also tested under bending conditions. The presented results demonstrate that bending has a minor effect on the antenna performance within the target frequency range. The measured results show a good agreement with simulations.
Community-care unit model of residential mental health rehabilitation services in Queensland, Australia: predicting outcomes of consumers 1-year post discharge
Authors: Parker S. , Arnautovska U. , Siskind D. , Dark F. , McKeon G. , Korman N. , Harris M.
Published: March 2020

Aims

Community care units (CCUs) are a model of residential psychiatric rehabilitation aiming to improve the independence and community functioning of people with severe and persistent mental illness. This study examined factors predicting improvement in outcomes among CCU consumers.

Methods

Hierarchical regression using data from a retrospective cohort (N = 501) of all consumers admitted to five CCUs in Queensland, Australia between 2005 and 2014. The primary outcome was changed in mental health and social functioning (Health of the Nation Outcome Scale). Secondary outcomes were disability (Life Skills Profile-16), service use, accommodation instability, and involuntary treatment. Potential predictors covered service, consumer, and treatment characteristics. Group-level and individualised change were assessed between the year pre-admission and post-discharge. Where relevant and available, the reliable and clinically significant (RCS) change was assessed by comparison with a normative sample.

Results

Group-level analyses showed statistically significant improvements in mental health and social functioning, and reductions in psychiatry-related bed-days, emergency department (ED) presentations and involuntary treatment. There were no significant changes in disability or accommodation instability. A total of 54.7% of consumers demonstrated reliable improvement in mental health and social functioning, and 43.0% showed RCS improvement. The majority (60.6%) showed a reliable improvement in psychiatry-related bed-use; a minority demonstrated reliable improvement in ED presentations (12.5%). Significant predictors of improvement included variables related to the CCU care (e.g. episode duration), consumer characteristics (e.g. primary diagnosis) and treatment variables (e.g. psychiatry-related bed-days pre-admission). Higher baseline impairment in mental health and social functioning (β = 1.12) and longer episodes of CCU care (β = 1.03) increased the likelihood of RCS improvement in mental health and social functioning.

Conclusions

CCU care was followed by reliable improvements in relevant outcomes for many consumers. Consumers with poorer mental health and social functioning, and a longer episode of CCU care were more likely to make RCS improvements in mental health and social functioning.
A healthy dietary pattern may be associated with primary insomnia	among Iranian adults: A case-control study
Authors: Sadat Samaneh , Salehi-sahlabadi Ammar , Pourmasoumi Makan , Feizi Awat , Clark Cain C. T. , Akkasheh Goudarz , Ghiasvand Reza
Published: March 2020

Abstract. Objective: While it has been reported that both foods and nutrients for individuals are connected with sleep, there is no evidence regarding the association of dietary patterns, identified by factor analysis, with primary insomnia. The present study sought to evaluate the association between major dietary patterns and the chance of having primary insomnia. Methods: The present case-control study was performed using 444 people (111 cases and 333 control), aged 18 to 60 years, referred to Isfahan health centers. Dietary intake was assessed via a food frequency questionnaire in a case-control study in Isfahan, Iran. Principal component analysis was used to determine major dietary patterns. The presence of primary insomnia was measured via the insomnia severity index questionnaire, and the subjects were grouped as healthy or insomniac. Results: Three major dietary patterns were recognized, and named; Western, Iranian Traditional and Healthy, respectively. The cumulative percentage of variance explained by three dietary patterns was 48.2%. Those in second (OR = 0.30; 95%CI: 0.2–0.46) and third (OR = 0.22; 95%CI: 0.15–0.35) tertiles of healthy dietary pattern were less likely suffer with insomnia. This association remained significant only in the highest tertile after adjusting potential confounders (OR = 0.45; 95%CI: 0.32–0.95). We found no significant association between greater adherence to Western or Iranian traditional dietary patterns and primary insomnia. Conclusions: The findings showed that although no statistically significant association was observed between both Western and Iranian traditional dietary patterns with primary insomnia, people with greater adherence to the healthy dietary pattern are less likely to have primary insomnia.
Subseasonal to Seasonal Prediction of Weather to Climate with Application to Tropical Cyclones
Authors: Robertson Andrew W. , Vitart Frederic , Camargo Suzana J.
Published: March 2020

Demands are growing rapidly in the operational prediction and applications communities for forecasts that fill the gap between daily weather forecasts and seasonal climate outlooks. Recent scientific advances have identified sources of predictability on this time range, and modeling advances are leading to better forecasts. However, much remains to be done to further improve their skill and to develop new climate service forecast products to help countries and sectorial decision makers better manage weather risks and extremes and to adapt to climate change. This paper reviews the history and describes the main challenges and opportunities for the modeling and forecast‐applications communities to improve subseasonal to seasonal (S2S) forecasts and products, along with current developments catalyzed by the World Weather Research Programme and World Climate Research Programme's joint Sub‐Seasonal to Seasonal Prediction Project. The case of tropical cyclones is highlighted as an illustrative example of the points discussed.
The Interplay of Recent Vegetation and Sea Ice Dynamics—Results From a Regional Earth System Model Over the Arctic
Authors: Zhang W. , Döscher R. , Koenigk T. , Miller P.A. , Jansson C. , Samuelsson P. , Wu M. , Smith B.
Published: March 2020

Recent accelerated warming over the Arctic coincides with sea ice reduction and shifting patterns of land cover. We use a state‐of‐the‐art regional Earth system model, RCAO‐GUESS, which comprises a dynamic vegetation model (LPJ‐GUESS), a regional atmosphere model (RCA), and an ocean sea ice model (RCO), to explore the dynamic coupling between vegetation and sea ice during 1989–2011. Our results show that RCAO‐GUESS captures recent trends in observed sea ice concentration and extent, with the inclusion of vegetation dynamics resulting in larger, more realistic variations in summer and autumn than the model that does not account for vegetation dynamics. Vegetation feedbacks induce concomitant changes in downwelling longwave radiation, near‐surface temperature, mean sea level pressure, and sea ice reductions, suggesting a feedback chain linking vegetation change to sea ice dynamics. This study highlights the importance of including interactive vegetation dynamics in modeling the Arctic climate system, particularly when predicting sea ice dynamics.
Seasonal Reversal of the Near‐Surface Chlorophyll Response to the Presence of Mesoscale Eddies in the South Pacific Subtropical Countercurrent
Authors: Travis Seth , Qiu Bo
Published: March 2020

Mesoscale eddies have been shown to have significant effects on biogeochemical cycles, as observed in local levels of near‐surface chlorophyll. There are many regional differences in the expected response of near‐surface chlorophyll to the presence of eddies, caused by differences in the driving mechanisms. However, in many high eddy activity areas, previous studies found low correlation and an inconsistent chlorophyll anomaly response to the presence of eddies. One such area is in the South Pacific Subtropical Countercurrent. Using GlobColour ocean color data and Aviso altimetry data, an investigation of the area found that a seasonal reversal occurs in the character of the chlorophyll anomaly within eddies (reversal from positive to negative and vice versa). The cause of this reversal is inferred to be a seasonally changing limiting factor within the region. Argo float profiles colocated inside and outside of eddies are used to show the coincidence of chlorophyll anomalies with seasonally changing mixed layer depths and the ability of the eddies to access deep nutrient pools. Observations of other mechanisms, such as eddy stirring or eddy‐Ekman pumping, are found to be seasonally less important than the mixed layer depth change‐induced nutrient flux . Additionally, metrics are developed to globally identify oceanic regions in which such seasonal reversals in chlorophyll anomalies could occur.
The Impact of Initial Tracer Profile on the Exchange and On‐Shelf Distribution of Tracers Induced by a Submarine Canyon
Authors: Ramos‐Musalem Karina , Allen Susan E.
Published: March 2020

Submarine canyons enhance cross‐shelf mass exchanges, which are a key component of on‐shelf nutrient budgets and biogeochemical cycles. Previous studies assume that canyon‐induced tracer flux onto the shelf only depends on canyon‐induced water upwelling. This paper investigates the validity of this dependence for nutrients, carbon, and dissolved gasses. To estimate the canyon‐induced tracer upwelling flux and its spatial distribution on the shelf, we performed numerical experiments simulating an upwelling event near an idealized canyon, adding 10 passive tracers with initial profiles representing nutrients, carbon, and dissolved gasses. This paper presents a scaling estimate for canyon‐induced tracer upwelling and for the on‐shelf distribution of a given tracer. We find that tracer upwelling depends on the vertical local mean of the initial vertical tracer gradient within the canyon, the depth of upwelling and the upwelling flux. We identify a pool of low oxygen and high nutrient concentration, methane, dissolved inorganic carbon, and total alkalinity on the shelf bottom, downstream of the canyon. The downstream extension of the pool of low oxygen water depends on the onshore flux of water through the canyon and the oxygen profile. This canyon‐induced distribution of tracers has the potential to impact demersal and benthic ecosystems by lowering dissolved oxygen levels and spreading corrosive waters along the shelf.
Water Mass and Biogeochemical Variability in the Kerguelen Sector of the Southern Ocean: A Machine Learning Approach for a Mixing Hot Spot
Authors: Rosso Isabella , Mazloff Matthew R. , Talley Lynne D. , Purkey Sarah G. , Freeman Natalie M. , Maze Guillaume
Published: March 2020

The Southern Ocean (SO) is one of the most energetic regions in the world, where strong air‐sea fluxes, oceanic instabilities, and flow‐topography interactions yield complex dynamics. The Kerguelen Plateau (KP) region in the Indian sector of the SO is a hot spot for these energetic dynamics, which result in large spatiotemporal variability of physical and biogeochemical properties throughout the water column. Data from Argo floats (including biogeochemical) are used to investigate the spatial variability of intermediate and deep water physical and biogeochemical properties. An unsupervised machine learning classification approach is used to organize the float profiles into five SO frontal zones based on their temperature and salinity structure between 300 and 900 m, revealing not only the location of frontal zones and their boundaries but also the variability of water mass properties relative to the zonal mean state. We find that the variability is property dependent and can be more than twice as large as the mean zonal variability in intense eddy fields. In particular, we observe this intense variability in the intermediate and deep waters of the Subtropical Zone; in the Subantarctic Zone just west of and at KP; east of KP in the Polar Frontal Zone, associated with intense eddy variability that enhances deep waters convergence and mixing; and, as the deep waters upwell to the upper 500 m and mix with the surface waters in the southernmost regimes, each property shows a large variability.
Consumption Change Detection for Urban Planning: Monitoring and Segmenting Water Customers During Drought
Authors: Bolorinos Jose , Ajami Newsha K. , Rajagopal Ram
Published: March 2020

Demand management is a powerful way for water utilities to address the challenges of population growth and climate change. Although active conservation efforts have been studied extensively, recent evidence suggests households respond to many external events beyond a utility's control, including political responses to extreme climatic episodes and corresponding mass media coverage. Despite their importance, these external factors are difficult to analyze in a controlled setting, and few tools exist to evaluate their influence on customers. Here, we present a consumption change detection (CCD) method that offers new insights into how climate‐related mass media and policy events affect conservation by pinpointing the timing and magnitude of customer‐level water use shifts. We use CCD to monitor and segment the responses of residential water customers to policy and media events in Costa Mesa, California, during the severe 2012–2016 drought. Our results show consumption reductions among 75% of customers. Of these, 80% reduced water use before mandatory restrictions were imposed, coincident with intensifying state policy responses and spikes in media coverage that affected all customer types during 2014. Analysis of standardized drought consumption trajectories indicates that 16% of conserving customers increased consumption in 2015–2016. Conservation and rebound were both more likely among affluent and educated customers, suggesting that CCD can identify engaged and informed water savers who make suitable targets for water‐efficient retrofit incentive schemes. This study demonstrates CCD's potential as a novel demand analysis tool in an interconnected world where external social, political, and climatic stressors can exert an important influence on customer behavior.
Pharmacological induction of selective endoplasmic reticulum retention as a strategy for cancer therapy
Authors: Mahameed Mohamed , Boukeileh Shatha , Obiedat Akram , Darawshi Odai , Dipta Priya , Rimon Amit , McLennan Gordon , Fassler Rosi , Reichmann Dana , Karni Rotem , Preisinger Christian , Wilhelm Thomas , Huber Michael , Tirosh Boaz
Published: March 2020

The integrated stress response (ISR) converges on eIF2α phosphorylation to regulate protein synthesis. ISR is activated by several stress conditions, including endoplasmic reticulum (ER) stress, executed by protein kinase R-like endoplasmic reticulum kinase (PERK). We report that ER stress combined with ISR inhibition causes an impaired maturation of several tyrosine kinase receptors (RTKs), consistent with a partial block of their trafficking from the ER to the Golgi. Other proteins mature or are secreted normally, indicating selective retention in the ER (sERr). sERr is relieved upon protein synthesis attenuation and is accompanied by the generation of large mixed disulfide bonded complexes, including ERp44. sERr was pharmacologically recapitulated by combining the HIV-protease inhibitor nelfinavir with ISRIB, an experimental drug that inhibits ISR. Nelfinavir/ISRIB combination is highly effective to inhibit the growth of RTK-addicted cell lines and hepatocellular (HCC) cells in vitro and in vivo. Thus, pharmacological sERr can be utilized as a modality for cancer treatment.
Publisher Correction: Enhanced energy-constrained quantum communication over bosonic Gaussian channels
Authors: Noh Kyungjoo , Pirandola Stefano , Jiang Liang
Published: March 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Author Correction: Spatial separation of catches in highly mixed fisheries
Authors: Dolder Paul J. , Thorson James T. , Minto Cóilín
Published: March 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Functional Imaging of the Outer Retinal Complex using High Fidelity Imaging Retinal Densitometry
Authors: Margrain Tom H. , Atkinson David , Binns Alison M. , Fergusson James , Gaffney Allannah , Henry David , Jones Chris , Lamb Trevor D. , Melotte Dave , Miller Chris , Todd Stephen , Wood Ashley
Published: March 2020

We describe a new technique, high fidelity Imaging Retinal Densitometry (IRD), which probes the functional integrity of the outer retinal complex. We demonstrate the ability of the technique to map visual pigment optical density and synthesis rates in eyes with and without macular disease. A multispectral retinal imaging device obtained precise measurements of retinal reflectance over space and time. Data obtained from healthy controls and 5 patients with intermediate AMD, before and after photopigment bleaching, were used to quantify visual pigment metrics. Heat maps were plotted to summarise the topography of rod and cone pigment kinetics and descriptive statistics conducted to highlight differences between those with and without AMD. Rod and cone visual pigment synthesis rates in those with AMD (v = 0.043 SD 0.019 min−1 and v = 0.119 SD 0.046 min−1, respectively) were approximately half those observed in healthy controls (v = 0.079 SD 0.024 min−1 for rods and v = 0.206 SD 0.069 min−1 for cones). By mapping visual pigment kinetics across the central retina, high fidelity IRD provides a unique insight into outer retinal complex function. This new technique will improve the phenotypic characterisation, diagnosis and treatment monitoring of various ocular pathologies, including AMD.
Correlation between TM joint disease and rheumatic diseases detected on bone scintigraphy and clinical factors
Authors: Shim Ji Suk , Kim Chulhan , Ryu Jae Jun , Choi Sung Jae
Published: March 2020

The aim of this study was to evaluate the effect of rheumatic disease as a risk factor for temporomandibular disease (TMD). A total of 143 outpatients reporting symptoms indicating rheumatic disease at their first visit to the rheumatology clinic were included. We evaluated the temporomandibular joint (TMJ) with scintigraphic images, and standard questionnaires were administered for the symptomatic assessment for all patients. The patients were classified into ‘healthy controls’ or as per their diagnosis into ‘osteoarthritis’, ‘axial spondyloarthritis’, ‘peripheral spondyloarthritis’, ‘rheumatoid arthritis’, or ‘other rheumatic diseases’ groups. The patients were also differentiated depending on the presence or absence of axial involvement. The relation between the rheumatic disease type and findings at the TMJ were evaluated using statistical analyses. Axial spondyloarthritis, peripheral spondyloarthritis, and rheumatic arthritis patients showed significantly higher scintigraphic uptake at the TMJ compared with those in the control and osteoarthritis groups (axial spondyloarthritis: 4.5, peripheral spondyloarthritis: 4.5, rheumatoid arthritis: 4.09, control: 3.5, osteoarthritis: 3.4, p < 0.0001). Compared with patients without axial involvement, patients with axial involvement also showed significantly higher TMJ scintigraphic uptake (axial involvement: 4.24, without axial involvement: 3.50, p < 0.0001) with elevated symptomatic rates in TMD (axial involvement: 17.82, without axial involvement: 9.97, p < 0.005).
Endothelial-specific Loss of IFT88 Promotes Endothelial-to-Mesenchymal Transition and Exacerbates Bleomycin-induced Pulmonary Fibrosis
Authors: Singh Shweta , Adam Mohamed , Matkar Pratiek N. , Bugyei-Twum Antoinette , Desjardins Jean-Francois , Chen Hao H. , Nguyen Hien , Bazinet Hannah , Michels David , Liu Zongyi , Mebrahtu Elizabeth , Esene Lillian , Joseph Jameela , Ehsan Mehroz , Qadura Mohammad , Connelly Kim A. , Leong-Poi Howard , Singh Krishna K.
Published: March 2020

Intraflagellar transport protein 88 (Ift88) is required for ciliogenesis and shear stress-induced dissolution of cilia in embryonic endothelial cells coincides with endothelial-to-mesenchymal transition (EndMT) in the developing heart. EndMT is also suggested to underlie heart and lung fibrosis, however, the mechanism linking endothelial Ift88, its effect on EndMT and organ fibrosis remains mainly unexplored. We silenced Ift88 in endothelial cells (ECs) in vitro and generated endothelial cell-specific Ift88-knockout mice (Ift88endo) in vivo to evaluate EndMT and its contribution towards organ fibrosis, respectively. Ift88-silencing in ECs led to mesenchymal cells-like changes in endothelial cells. The expression level of the endothelial markers (CD31, Tie-2 and VE-cadherin) were significantly reduced with a concomitant increase in the expression level of mesenchymal markers (αSMA, N-Cadherin and FSP-1) in Ift88-silenced ECs. Increased EndMT was associated with increased expression of profibrotic Collagen I expression and increased proliferation in Ift88-silenced ECs. Loss of Ift88 in ECs was further associated with increased expression of Sonic Hedgehog signaling effectors. In vivo, endothelial cells isolated from the heart and lung of Ift88endo mice demonstrated loss of Ift88 expression in the endothelium. The Ift88endo mice were born in expected Mendelian ratios without any adverse cardiac phenotypes at baseline. Cardiac and pulmonary endothelial cells isolated from the Ift88endo mice demonstrated signs of EndMT and bleomycin treatment exacerbated pulmonary fibrosis in Ift88endo mice. Pressure overload stress in the form of aortic banding did not reveal a significant difference in cardiac fibrosis between Ift88endo mice and control mice. Our findings demonstrate a novel association between endothelial cilia with EndMT and cell proliferation and also show that loss of endothelial cilia-associated increase in EndMT contributes specifically towards pulmonary fibrosis.
Adaptations of Interferon Regulatory Factor 3 with Transition from Terrestrial to Aquatic Life
Authors: Angeletti Monica , Hsu Wan-Ling Nicole , Majo Nashaat , Moriyama Hideaki , Moriyama Etsuko N. , Zhang Luwen
Published: March 2020

Interferon regulatory factor 3 (IRF3) and IRF7 are closely related IRF members and the major factors for the induction of interferons, a key component in vertebrate innate immunity. However, there is limited knowledge regarding the evolution and adaptation of those IRFs to the environments. Two unique motifs in IRF3 and 7 were identified. One motif, GASSL, is highly conserved throughout the evolution of IRF3 and 7 and located in the signal response domain. Another motif, DPHK, is in the DNA-binding domain. The ancestral protein of IRF3 and 7 seemed to possess the DPHK motif. In the ray-finned fish lineage, while the DPHK is maintained in IRF7, the motif in IRF3 is changed to NPHK with a D → N amino acid substitution. The D → N substitution are also found in amphibian IRF3 but not in amphibian IRF7. Terrestrial animals such as reptiles and mammals predominantly use DPHK sequences in both IRF3 and 7. However, the D → N substitution in IRF3 DPHK is again found in cetaceans such as whales and dolphins as well as in marsupials. These observations suggest that the D → N substitutions in the IRF3 DPHK motif is likely to be associated with vertebrate’s adaptations to aquatic environments and other environmental changes.
Adhesion between P. falciparum infected erythrocytes and human endothelial receptors follows alternative binding dynamics under flow and febrile conditions
Authors: Lubiana Pedro , Bouws Philip , Roth Lisa Katharina , Dörpinghaus Michael , Rehn Torben , Brehmer Jana , Wichers Jan Stephan , Bachmann Anna , Höhn Katharina , Roeder Thomas , Thye Thorsten , Gutsmann Thomas , Burmester Thorsten , Bruchhaus Iris , Metwally Nahla Galal
Published: March 2020

Characterizing the adhesive dynamics of Plasmodium falciparum infected erythrocytes (IEs) to different endothelial cell receptors (ECRs) in flow is a big challenge considering available methods. This study investigated the adhesive dynamics of IEs to five ECRs (CD36, ICAM-1, P-selectin, CD9, CSA) using simulations of in vivo-like flow and febrile conditions. To characterize the interactions between ECRs and knobby and knobless IEs of two laboratory-adapted P. falciplarum isolates, cytoadhesion analysis over time was performed using a new tracking bioinformatics method. The results revealed that IEs performed rolling adhesion exclusively over CD36, but exhibited stationary binding to the other four ECRs. The absence of knobs affected rolling adhesion both with respect to the distance travelled by IEs and their velocity. Knobs played a critical role at febrile temperatures by stabilizing the binding interaction. Our results clearly underline the complexity of the IE-receptor interaction and the importance of knobs for the survival of the parasite at fever temperatures, and lead us to propose a new hypothesis that could open up new strategies for the treatment of malaria.