bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplemental Figure 1 from Dietary Microbes Modulate Transgenerational Cancer Risk
Authors: Poutahidis Theofilos , Varian Bernard J. , Levkovich Tatiana , Lakritz Jessica R. , Mirabal Sheyla , Kwok Caitlin , Ibrahim Yassin M. , Kearney Sean M. , Chatzigiagkos Antonis , Alm Eric J. , Erdman Susan E.
Published: March 2023

(A) Selected immunohistochemical features of transgenerational neoplasms including TTF1 immunoreactivity of pulmonary carcinoma, Von Willebrand factor expression of hepatic hemagiosarcoma and high numbers of proliferating ki-67-positive cells of theca cell tumor of the ovary. Foci of neoplastic cells with nuclear p53 accumulation in hepatocellular carcinoma (left), pulmonary carcinoma (middle) and ovarian thecoma (right panel). (B) Histology of underrepresented transgenerational cancers. Typical histomorphology of islet cell adenoma of pancreas, ovarian granulosa cell tumor and skin lymphoma. (C) Tabular display of lung and liver tumor types according to treatment. IHC; Di-aminobenzidine chromogen, Hematoxylin counterstain. (A). Hematoxylin and Eosin (B).
Supplementary Method, Supplementary Tables, and Supplementary Figures from Photodynamic Therapy Synergizes with Irinotecan to Overcome Compensatory Mechanisms and Improve Treatment Outcomes in Pancreatic Cancer
Authors: Huang Huang-Chiao , Mallidi Srivalleesha , Liu Joyce , Chiang Chun-Te , Mai Zhiming , Goldschmidt Ruth , Ebrahim-Zadeh Neema , Rizvi Imran , Hasan Tayyaba
Published: March 2023

(i) Supplementary Methods 1. Synthesis of L-BPD and L-IRI via freeze-thaw extrusion method 2. Pharmacokinetics and biodistribution of L-BPD and L-IRI 3. In-vitro quantification of changes in ABCG2 expression using immunofluorescence 4. Ultrasound Imaging 5. Histology and immunofluorescence of tumor samples 6. Quantification of H&E and immunofluorescence biomarkers 7. Determination of Synergism (ii) Supplementary Tables Supplementary Table S1. Comparison of PDT and irinotecan doses used in this study versus in clinic Supplementary Table S2. List of antibodies used for immunofluorescence Supplementary Table S3. The synergistic effect of combination PDT and L-IRI Supplementary Table S4. Physical parameters of L-BPD and L-IRI (iii) Supplementary Figures and Legends Supplementary Fig. S1. Treatment schedule and longitudinal monitoring of PanCa tumors in vivo Supplementary Fig. S2. Sub-cytotoxic PDT leads to decreased levels of ABCG2 and increased intracellular irinotecan in AsPC-1 cells Supplementary Fig. S3. Tumor growth kinetics of MIA PACa-2 and AsPC-1 in vivo Supplementary Fig. S4. Change in mouse body weight after combination treatment
Supplementary Tables S1-S3 from Exosomes Derived from Hypoxic Oral Squamous Cell Carcinoma Cells Deliver miR-21 to Normoxic Cells to Elicit a Prometastatic Phenotype
Authors: Li Ling , Li Chao , Wang Shaoxin , Wang Zhaohui , Jiang Jian , Wang Wei , Li Xiaoxia , Chen Jin , Liu Kun , Li Chunhua , Zhu Guiquan
Published: March 2023

Summary of small RNA sequencing of hypoxic and normoxic exosomes (S1); Number of miRNA identified in each sample (S2); Characteristics of 108 patients with OSCC and matched volunteers (S3).
Supplementary Methods and References from Exosomes Derived from Hypoxic Oral Squamous Cell Carcinoma Cells Deliver miR-21 to Normoxic Cells to Elicit a Prometastatic Phenotype
Authors: Li Ling , Li Chao , Wang Shaoxin , Wang Zhaohui , Jiang Jian , Wang Wei , Li Xiaoxia , Chen Jin , Liu Kun , Li Chunhua , Zhu Guiquan
Published: March 2023

Description of additional methods and procedures used in the study. Also includes Supplementary References.
Supplementary Figure S3 from Exosomes Derived from Hypoxic Oral Squamous Cell Carcinoma Cells Deliver miR-21 to Normoxic Cells to Elicit a Prometastatic Phenotype
Authors: Li Ling , Li Chao , Wang Shaoxin , Wang Zhaohui , Jiang Jian , Wang Wei , Li Xiaoxia , Chen Jin , Liu Kun , Li Chunhua , Zhu Guiquan
Published: March 2023

miR-21 levels in exosomes derived from wild-type and miR-21 KD cells were measured by quantitative real-time PCR.
Supplemental Figure Legends from Cdx2 Expression and Intestinal Metaplasia Induced by H. pylori Infection of Gastric Cells Is Regulated by NOD1-Mediated Innate Immune Responses
Authors: Asano Naoki , Imatani Akira , Watanabe Tomohiro , Fushiya Jun , Kondo Yutaka , Jin Xiaoyi , Ara Nobuyuki , Uno Kaname , Iijima Katsunori , Koike Tomoyuki , Strober Warren , Shimosegawa Tooru
Published: March 2023

Supplementary Figure Legends
Table S1 from Formation of Renal Cysts and Tumors in Vhl/Trp53-Deficient Mice Requires HIF1α and HIF2α
Authors: Schönenberger Désirée , Harlander Sabine , Rajski Michal , Jacobs Robert A. , Lundby Anne-Kristine , Adlesic Mojca , Hejhal Tomas , Wild Peter J. , Lundby Carsten , Frew Ian J.
Published: March 2023

Lists of Hif1a and Hif2a dependent genes induced by Vhl deletion in primary renal epithelial cells
Supplementary Figures S1-S8 from Formation of Renal Cysts and Tumors in Vhl/Trp53-Deficient Mice Requires HIF1α and HIF2α
Authors: Schönenberger Désirée , Harlander Sabine , Rajski Michal , Jacobs Robert A. , Lundby Anne-Kristine , Adlesic Mojca , Hejhal Tomas , Wild Peter J. , Lundby Carsten , Frew Ian J.
Published: March 2023

Additional data related to histological analyses, establishing renal epithelial cell culture, analyses of microarray data and further analyses of Vhl/Trp53-, Vhl/Trp53/Hif1a- and Vhl/Trp53/Hif2a-deficient mice,
Table S1 from RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non–Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway
Authors: Dubois Fatéméh , Keller Maureen , Calvayrac Olivier , Soncin Fabrice , Hoa Lily , Hergovich Alexander , Parrini Maria-Carla , Mazières Julien , Vaisse-Lesteven Mélissa , Camonis Jacques , Levallet Guénaëlle , Zalcman Gérard
Published: March 2023

Human epithelial bronchial and lung cancer cell lines used in this study.
Supplementary Table 3 from Phosphotyrosine Signaling Analysis in Human Tumors Is Confounded by Systemic Ischemia-Driven Artifacts and Intra-Specimen Heterogeneity
Authors: Gajadhar Aaron S. , Johnson Hannah , Slebos Robbert J.C. , Shaddox Kent , Wiles Kerry , Washington Mary Kay , Herline Alan J. , Levine Douglas A. , Liebler Daniel C. , White Forest M.
Published: March 2023

Supplementary Table 3. Summary of similar ischemia response temporal patterns observed across multiple ovarian tumors, as shown in Supplementary Figure 4.
Supplementary Table 1 from Phosphotyrosine Signaling Analysis in Human Tumors Is Confounded by Systemic Ischemia-Driven Artifacts and Intra-Specimen Heterogeneity
Authors: Gajadhar Aaron S. , Johnson Hannah , Slebos Robbert J.C. , Shaddox Kent , Wiles Kerry , Washington Mary Kay , Herline Alan J. , Levine Douglas A. , Liebler Daniel C. , White Forest M.
Published: March 2023

Supplementary Table 1. Ovarian pTyr ischemia response
Figure S8: RhoA activity is not influenced by RASSF1A depletion whereas constitutive activation of a Rho activity by Narciclasine still impairs RASSF1A-induced invasion. from RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non–Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway
Authors: Dubois Fatéméh , Keller Maureen , Calvayrac Olivier , Soncin Fabrice , Hoa Lily , Hergovich Alexander , Parrini Maria-Carla , Mazières Julien , Vaisse-Lesteven Mélissa , Camonis Jacques , Levallet Guénaëlle , Zalcman Gérard
Published: March 2023

A) GST pull-down assay in HBEC-3 cells. Quantification of active GTP-bound RhoA levels as determined by western blotting. One representative experiment is shown in a top panel of histogram. B & C) HBEC-3 cells were transiently transfected with non-silencing siRNA (siNeg), siRASSF1A-1 in combination or not with B) three plasmids coding for wt-RhoA, RhoA N19 (dominant negative form) & RhoAV14 (constitutively active form) C) Cells were assayed for their invasive capacities with Narciclasine treatment. The invasion capacity was assessed using a BioCoat Matrigel Invasion Chamber. The relative invasion was normalized to that of the cells transfected with siNeg. D) Nuclear intensity of YAP was assessed by immunofluorescence and confocal microscopy (right panel), upon depletion of RASSF1A, transfection of RhoAwt expressing plasmid, co-transfection of siRASSF1A and RhoAwt plasmid, transfection of dominant negative RhoAN19 plasmid alone, or upon RASSF1A depletion, transfection of constitutively active RhoAV14 plasmid alone or upon RASSF1A depletion. For all of the histograms, error bars indicate the standard error of the mean (SEM) of at least three independent experiments. *p<0.05, **p<0.01 and ***p<0.001, using an ANOVA test followed by Dunnett's test. E) PP1 protein expression assessed by western-blot upon RASS1A depletion or RASSF1A and 1C depletion. Error bars in histograms indicate the standard error of the mean (SEM) of at least three independent experiments. F) One representative experiment of PP2ACalpha Immunoprecipitation is shown in BEAS-2B cells grew exponentially, followed by PP2ACalpha or RhoB western-blottings, with corresponding specific antibodies. G) Representative images for Ser885-phosphoGEF-H1 staining assessed by immunofluorescence and confocal microscopy, upon RASSF1A, PP2ACalpha, RhoB or GEF-H1 depletion. The cells were stained by Ser885-phosphoGEF-H1 primary antibody (Green) followed by Alexa488 conjugated secondary antibody, along with DAPI for DNA (Blue). H) Quantification of ANKDR1 & CTGF mRNA using actin as an internal control.
Supplemental Methods from Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem–like Cells
Authors: Giraud Julie , Failla Laura M. , Pascussi Jean-Marc , Lagerqvist Ebba L. , Ollier Jérémy , Finetti Pascal , Bertucci François , Ya Chu , Gasmi Imène , Bourgaux Jean-François , Prudhomme Michel , Mazard Thibault , Ait-Arsa Imade , Houhou Leila , Birnbaum Daniel , Pélegrin André , Vincent Charles , Ryall James G. , Joubert Dominique , Pannequin Julie , Hollande Frédéric
Published: March 2023

Description of additional methods and procedures used in the study.
Supplemental Figure 3 from M-COPA, a Golgi Disruptor, Inhibits Cell Surface Expression of MET Protein and Exhibits Antitumor Activity against MET-Addicted Gastric Cancers
Authors: Ohashi Yoshimi , Okamura Mutsumi , Hirosawa Asaka , Tamaki Naomi , Akatsuka Akinobu , Wu Kuo-Ming , Choi Hyeong-Wook , Yoshimatsu Kentaro , Shiina Isamu , Yamori Takao , Dan Shingo
Published: March 2023

Effect of M-COPA on cell surface expression of EGFR in MET-unamplified GC cell lines.
Supplementary Table S7 from Quantitative Phosphotyrosine Profiling of Patient-Derived Xenografts Identifies Therapeutic Targets in Pediatric Leukemia
Authors: Dolai Sibasish , Sia Keith C.S. , Robbins Alissa K. , Zhong Ling , Heatley Sue L. , Vincent Tiffaney L. , Hochgräfe Falko , Sutton Rosemary , Kurmasheva Raushan T. , Revesz Tamas , White Deborah L. , Houghton Peter J. , Smith Malcolm A. , Teachey David T. , Daly Roger J. , Raftery Mark J. , Lock Richard B.
Published: March 2023

Enriched Class I tyrosine phosphorylated sites of TKs in ALL-77 PDX
Supplementary Figure Legends from MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin
Authors: O'Brien Rosemary , Tran Sieu L. , Maritz Michelle F. , Liu Bing , Kong Cheng Fei , Purgato Stefania , Yang Chen , Murray Jayne , Russell Amanda J. , Flemming Claudia L. , von Jonquieres Georg , Pickett Hilda A. , London Wendy B. , Haber Michelle , Gunaratne Preethi H. , Norris Murray D. , Perini Giovanni , Fletcher Jamie I. , MacKenzie Karen L.
Published: March 2023

Text file of Figure Legends to Supplementary data
Supplementary Figure 6 from Copy Number Alterations in Enzyme-Coding and Cancer-Causing Genes Reprogram Tumor Metabolism
Authors: Sharma Ashwini Kumar , Eils Roland , König Rainer
Published: March 2023

Heatmap of prioritized cancer metabolic gene set.
Supplemental Figure legends and Tables from Rictor/mTORC2 Drives Progression and Therapeutic Resistance of HER2-Amplified Breast Cancers
Authors: Morrison Joly Meghan , Hicks Donna J. , Jones Bayley , Sanchez Violeta , Estrada Monica Valeria , Young Christian , Williams Michelle , Rexer Brent N. , Sarbassov Dos D. , Muller William J. , Brantley-Sieders Dana , Cook Rebecca S.
Published: March 2023

Supplemental Figure Legends and Supplemental tables (Table 1 and table 2)
Supplemental Figure S2 from Identification of Bone-Derived Factors Conferring De Novo Therapeutic Resistance in Metastatic Prostate Cancer
Authors: Lee Yu-Chen , Lin Song-Chang , Yu Guoyu , Cheng Chien-Jui , Liu Bin , Liu Hsuan-Chen , Hawke David H. , Parikh Nila U. , Varkaris Andreas , Corn Paul , Logothetis Christopher , Satcher Robert L. , Yu-Lee Li-Yuan , Gallick Gary E. , Lin Sue-Hwa
Published: March 2023

Tumor recurrence after discontinuation of cabozantinib treatment.
Supplementary Figure 1 from Neutrophil Extracellular Traps Promote the Development and Progression of Liver Metastases after Surgical Stress
Authors: Tohme Samer , Yazdani Hamza O. , Al-Khafaji Ahmed B. , Chidi Alexis P. , Loughran Patricia , Mowen Kerri , Wang Yanming , Simmons Richard L. , Huang Hai , Tsung Allan
Published: March 2023

Supplementary Figure 1. Flow cytometric analysis of purity of neutrophil isolation technique from bone marrow of mice.
Supplementary Figure 6 from GSK-3 Inhibition Sensitizes Acute Myeloid Leukemia Cells to 1,25D-Mediated Differentiation
Authors: Gupta Kalpana , Stefan Tammy , Ignatz-Hoover James , Moreton Stephen , Parizher Gary , Saunthararajah Yogen , Wald David N.
Published: March 2023

Western blot control for JNK inhibition
supplemental figure 3 from Cytotoxic Properties of a DEPTOR-mTOR Inhibitor in Multiple Myeloma Cells
Authors: Shi Yijiang , Daniels-Wells Tracy R. , Frost Patrick , Lee Jihye , Finn Richard S. , Bardeleben Carolyne , Penichet Manuel L. , Jung Michael E. , Gera Joseph , Lichtenstein Alan
Published: March 2023

SUPPL FIG 3: A) Relative DEPTOR expression in MMCLs and hepatocellular carcinoma (HCC) cell lines in a representative experiment (upper panel) and means+/-SD of 3 experiments (lower bar graph); B) Relative sensitivity of U266 and FR4 MMCLs vs DEPTOR-expressing JHH7, HUH-1 or HIH7 HCCs; data are means +/- SD (n=3); Asterix demonstrates significant (p<0.05) decreased cell survival in MMCLs vs HCC cells ; C) MMCLs or HUH-1 HCC cells following shRNA transfection with control (scramble) or DEPTOR-targeted lentivirus; D) Percent apoptosis at 3 or 4 days following DEPTOR silencing in MMCLs or HUH-1 HCC; Data are means +/- SD, n=4 following transfection with control shRNA (scr) or shRNA targeting 2 separate sequences of DEPTOR.
Supplemental Figure S1 from Detection of Pancreatic Cancer–Induced Cachexia Using a Fluorescent Myoblast Reporter System and Analysis of Metabolite Abundance
Authors: Winnard Paul T. , Bharti Santosh K. , Penet Marie-France , Marik Radharani , Mironchik Yelena , Wildes Flonne , Maitra Anirban , Bhujwalla Zaver M.
Published: March 2023

Supplemental Figure S1. Real time optical imaging after 4 weeks of To3B graft growth in the hind leg muscle of a nude mouse indicating that a tdT fluorescent signal was observed only after i.p. administration of 100 μg of DEX 24 hr prior to imaging the live animal.
Supplementary Table 1 from Antibody-Targeted Chemotherapy for the Treatment of Melanoma
Authors: Nevala Wendy K. , Buhrow Sarah A. , Knauer Daniel J. , Reid Joel M. , Atanasova Elena A. , Markovic Svetomir N.
Published: March 2023

Mouse toxicity study of organs from 3 mice in each treatment group.
Supplementary Figure legend from T-cell Landscape in a Primary Melanoma Predicts the Survival of Patients with Metastatic Disease after Their Treatment with Dendritic Cell Vaccines
Authors: Vasaturo Angela , Halilovic Altuna , Bol Kalijn F. , Verweij Dagmar I. , Blokx Willeke A.M. , Punt Cornelis J.A. , Groenen Patricia J.T.A. , van Krieken J. Han J.M. , Textor Johannes , de Vries I. Jolanda M. , Figdor Carl G.
Published: March 2023

Supplementary Figure legend
Supplementary figure S2 from JX06 Selectively Inhibits Pyruvate Dehydrogenase Kinase PDK1 by a Covalent Cysteine Modification
Authors: Sun Wenyi , Xie Zuoquan , Liu Yifu , Zhao Dan , Wu Zhixiang , Zhang Dadong , Lv Hao , Tang Shuai , Jin Nan , Jiang Hualiang , Tan Minjia , Ding Jian , Luo Cheng , Li Jian , Huang Min , Geng Meiyu
Published: March 2023

JX06 exhibits no inhibitory effect on FAK at the cellular level.
Supplementary Table S1 from JX06 Selectively Inhibits Pyruvate Dehydrogenase Kinase PDK1 by a Covalent Cysteine Modification
Authors: Sun Wenyi , Xie Zuoquan , Liu Yifu , Zhao Dan , Wu Zhixiang , Zhang Dadong , Lv Hao , Tang Shuai , Jin Nan , Jiang Hualiang , Tan Minjia , Ding Jian , Luo Cheng , Li Jian , Huang Min , Geng Meiyu
Published: March 2023

An enzymatic screen towards PDK1 using a small molecule library composed of 591 commercially available known drugs.
Supplemental Figures 1 through 8 from Mesenchymal Stem Cell–Derived Exosomes Stimulate Cycling Quiescence and Early Breast Cancer Dormancy in Bone Marrow
Authors: Bliss Sarah A. , Sinha Garima , Sandiford Oleta A. , Williams Lisa M. , Engelberth Daniel J. , Guiro Khadidiatou , Isenalumhe Leidy L. , Greco Steven J. , Ayer Seda , Bryan Margarette , Kumar Rakesh , Ponzio Nicholas M. , Rameshwar Pranela
Published: March 2023

Supplemental Figures 1-8 to support the following: The validity of p63-GFP transfection normalized band densities for western blots; support for dicer knockdown; bioinformatics to support cycling changes of the exosomes; supporting evidence for the source of cellular miR222; support for sensitivity of detecting human breast cancer cells in the femurs of mice; showing the sensitivity of mesenchymal stem cells to carboplatin.
Supplementary Table 1 from miR-155 Drives Metabolic Reprogramming of ER+ Breast Cancer Cells Following Long-Term Estrogen Deprivation and Predicts Clinical Response to Aromatase Inhibitors
Authors: Bacci Marina , Giannoni Elisa , Fearns Antony , Ribas Ricardo , Gao Qiong , Taddei Maria Letizia , Pintus Gianfranco , Dowsett Mitch , Isacke Clare M. , Martin Lesley-Ann , Chiarugi Paola , Morandi Andrea
Published: March 2023

Supplementary Table S1. Combination Index (CI) analysis of MCF7-2A cells treated with letrozole and 2-deoxyglucose (2-DG).
Supplementary Tables from Germinal Centers Determine the Prognostic Relevance of Tertiary Lymphoid Structures and Are Impaired by Corticosteroids in Lung Squamous Cell Carcinoma
Authors: Siliņa Karīna , Soltermann Alex , Attar Farkhondeh Movahedian , Casanova Ruben , Uckeley Zina M. , Thut Helen , Wandres Muriel , Isajevs Sergejs , Cheng Phil , Curioni-Fontecedro Alessandra , Foukas Periklis , Levesque Mitchell P. , Moch Holger , Linē Aija , van den Broek Maries
Published: March 2023

Contains Supplementary Tables S1-S7. Supplementary Table S1 - clinical information of the Riga cohort; Supplementary Table S2 - primer sequences; Supplementary Table S3 - antibody list; Supplementary Table S4 - information about the indications for which corticosteroid therapy was prescribed; Supplementary Table S5 - summary of gene expression analysis results; Supplementary Table S6 - multivariate Cox regression analysis of the whole Zurich cohort; Supplementary Table S7 - Spearman correlation analysis of histological and clinical parameters.
Supplementary Table S2 from TG2 and NF-κB Signaling Coordinates the Survival of Mantle Cell Lymphoma Cells via IL6-Mediated Autophagy
Authors: Zhang Han , Chen Zheng , Miranda Roberto N. , Medeiros L. Jeffrey , McCarty Nami
Published: March 2023

Clinical features of the MCL patients.
Supplementary Figure Legends from Novel Protein Disulfide Isomerase Inhibitor with Anticancer Activity in Multiple Myeloma
Authors: Vatolin Sergei , Phillips James G. , Jha Babal K. , Govindgari Shravya , Hu Jennifer , Grabowski Dale , Parker Yvonne , Lindner Daniel J. , Zhong Fei , Distelhorst Clark W. , Smith Mitchell R. , Cotta Claudiu , Xu Yan , Chilakala Sujatha , Kuang Rebecca R. , Tall Samantha , Reu Frederic J.
Published: March 2023

Legends to Supplementary Figures S1-4
Supplemental Figure 2 from Cyclin A1 and P450 Aromatase Promote Metastatic Homing and Growth of Stem-like Prostate Cancer Cells in the Bone Marrow
Authors: Miftakhova Regina , Hedblom Andreas , Semenas Julius , Robinson Brian , Simoulis Athanasios , Malm Johan , Rizvanov Albert , Heery David M. , Mongan Nigel P. , Maitland Norman J. , Allegrucci Cinzia , Persson Jenny L.
Published: March 2023

Evaluate bone marrow metastasis initiated by PC3M cells via intracardiac injection of tumor cells into mice.
Supplemental Figure 1 from Cyclin A1 and P450 Aromatase Promote Metastatic Homing and Growth of Stem-like Prostate Cancer Cells in the Bone Marrow
Authors: Miftakhova Regina , Hedblom Andreas , Semenas Julius , Robinson Brian , Simoulis Athanasios , Malm Johan , Rizvanov Albert , Heery David M. , Mongan Nigel P. , Maitland Norman J. , Allegrucci Cinzia , Persson Jenny L.
Published: March 2023

PC3M cells overexpressing cyclin A1 initiated macro-metastases in distant organs in xenograft mice.
Suppl. Table 1 from HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors
Authors: Budina-Kolomets Anna , Webster Marie R. , Leu Julia I-Ju , Jennis Matthew , Krepler Clemens , Guerrini Anastasia , Kossenkov Andrew V. , Xu Wei , Karakousis Giorgos , Schuchter Lynn , Amaravadi Ravi K. , Wu Hong , Yin Xiangfan , Liu Qin , Lu Yiling , Mills Gordon B. , Xu Xiaowei , George Donna L. , Weeraratna Ashani T. , Murphy Maureen E.
Published: March 2023

Coefficient of interaction (CI) values for PET-16 and targeted therapeutic agent PLX4032 in BRAF V600E melanoma cell lines.
Supplementary Figure 6. from Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma
Authors: Cadamuro Massimiliano , Spagnuolo Gaia , Sambado Luisa , Indraccolo Stefano , Nardo Giorgia , Rosato Antonio , Brivio Simone , Caslini Chiara , Stecca Tommaso , Massani Marco , Bassi Nicolò , Novelli Eugenio , Spirli Carlo , Fabris Luca , Strazzabosco Mario
Published: March 2023

Supplementary Figure 6. EGI-1 cells but not TFK-1 cells contained SUMOylated S100A4; inhibitory effects of low dose PTX on SUMOylating complex did not associate with any deregulation of SUMO E subunits.
Supplemental Figure Legends from Immunoregulatory Protein B7-H3 Reprograms Glucose Metabolism in Cancer Cells by ROS-Mediated Stabilization of HIF1α
Authors: Lim Sangbin , Liu Hao , da Silva Luciana Madeira , Arora Ritu , Liu Zixing , Phillips Joshua B. , Schmitt David C. , Vu Tung , McClellan Steven , Lin Yifeng , Lin Wensheng , Piazza Gary A. , Fodstad Oystein , Tan Ming
Published: March 2023

Legends for Supplementary Figures
Supplementary Figures S1-S8 from Elucidation of the Roles of Tumor Integrin β1 in the Extravasation Stage of the Metastasis Cascade
Authors: Chen Michelle B. , Lamar John M. , Li Ran , Hynes Richard O. , Kamm Roger D.
Published: March 2023

In vitro microfluidics-based extravasation assays (S1); Knockdown of Î²1 integrin results in a reduction in extravasation rate (S2); Extravasation in vivo (S3); Analysis of adhesion rate in an endothelial monolayer microfluidic flow assay (S4); Visualization and scoring of transendothelial migration events in the vertical monolayer device (S5); Tumor cell protrusion dynamics in 3D collagen 1/fibrin mix matrices (S6); Î²1 integrin is required for invasion past the basement membrane (S7); Role of alpha integrins subunits in transendothelial migration in microvascular networks (S8).
Supplementary Tables from A KDM5 Inhibitor Increases Global H3K4 Trimethylation Occupancy and Enhances the Biological Efficacy of 5-Aza-2′-Deoxycytidine
Authors: Leadem Benjamin R. , Kagiampakis Ioannis , Wilson Catherine , Cheung Tommy K. , Arnott David , Trojer Patrick , Classon Marie , Easwaran Hariharan , Baylin Stephen B.
Published: March 2023

Contains Tables S1 and S2. Supplementary Table 1: List of PCR primers. Supplementary Table 2: Sensitivity of Breast Cancer Cell Lines to CPI-455 Cell Viability was measured following exposure to CPI-455 for 8 days.
Supplemental Figure 1 from Amphiregulin Is a Critical Downstream Effector of Estrogen Signaling in ERα-Positive Breast Cancer
Authors: Peterson Esther A. , Jenkins Edmund C. , Lofgren Kristopher A. , Chandiramani Natasha , Liu Hui , Aranda Evelyn , Barnett Maryia , Kenny Paraic A.
Published: March 2023

Additional representative examples of Amphiregulin immunostaining in breast cancer specimens
Supplementary Table S4 from Measurement of Endogenous versus Exogenous Formaldehyde–Induced DNA–Protein Crosslinks in Animal Tissues by Stable Isotope Labeling and Ultrasensitive Mass Spectrometry
Authors: Lai Yongquan , Yu Rui , Hartwell Hadley J. , Moeller Benjamin C. , Bodnar Wanda M. , Swenberg James A.
Published: March 2023

6 ppm NHP Exposure Results.
Supplemental Figure Legends from mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer
Authors: Driscoll David R. , Karim Saadia A , Sano Makoto , Gay David M. , Jacob Wright , Yu Jun , Mizukami Yusuke , Gopinathan Aarthi , Jodrell Duncan I. , Evans T.R. Jeffry , Bardeesy Nabeel , Hall Michael N. , Quattrochi Brian J. , Klimstra David S. , Barry Simon T. , Sansom Owen J. , Lewis Brian C. , Morton Jennifer P.
Published: March 2023

Supplementary figure legends for Figures S1-S8
Supplementary Table S4 from Molecular Evolution Patterns in Metastatic Lymph Nodes Reflect the Differential Treatment Response of Advanced Primary Lung Cancer
Authors: Um Sang-Won , Joung Je-Gun , Lee Hyun , Kim Hojoong , Kim Kyu-Tae , Park Jinha , Hayes D. Neil , Park Woong-Yang
Published: March 2023

Table S4. Mapping statistics of sequencing reads of whole-exome sequencing.
Supplementary Table S2 from Molecular Evolution Patterns in Metastatic Lymph Nodes Reflect the Differential Treatment Response of Advanced Primary Lung Cancer
Authors: Um Sang-Won , Joung Je-Gun , Lee Hyun , Kim Hojoong , Kim Kyu-Tae , Park Jinha , Hayes D. Neil , Park Woong-Yang
Published: March 2023

Table S2. Differentially activated pathways in TH1, TH5 and TH6 case. In TH1, TH5 and TH6 case, the pathway enrichment test was performed between two lymph nodes (4L and 4R) vs. 7 lymph node, between two lymph nodes (7 and 4L) vs. 11Rs lymph node & primary, and between three lymph nodes vs. primary, respectively. Significant pathways were not found in other cases.
Supplementary Figure S2 from LncRNA HOXA11-AS Promotes Proliferation and Invasion of Gastric Cancer by Scaffolding the Chromatin Modification Factors PRC2, LSD1, and DNMT1
Authors: Sun Ming , Nie Fengqi , Wang Yunfei , Zhang Zhihong , Hou Jiakai , He Dandan , Xie Min , Xu Lin , De Wei , Wang Zhaoxia , Wang Jun
Published: March 2023

E2F1 activated HOXA11-AS expression in GC cells.
Supplementary Figure 2 from Androgen and Estrogen Receptors in Breast Cancer Coregulate Human UDP-Glucuronosyltransferases 2B15 and 2B17
Authors: Hu Dong G. , Selth Luke A. , Tarulli Gerard A. , Meech Robyn , Wijayakumara Dhilushi , Chanawong Apichaya , Russell Roslin , Caldas Carlos , Robinson Jessica L.L. , Carroll Jason S. , Tilley Wayne D. , Mackenzie Peter I. , Hickey Theresa E.
Published: March 2023

Supplementary Figure 2. Kaplan-Meier survival plots showing relationship between UGTB215 and UGTB17 levels and outcome in distinct breast cancer subtypes.
Supplementary Figure S3 from The p53/p21 Complex Regulates Cancer Cell Invasion and Apoptosis by Targeting Bcl-2 Family Proteins
Authors: Kim Eun Mi , Jung Chan-Hun , Kim Jongdoo , Hwang Sang-Gu , Park Jong Kuk , Um Hong-Duck
Published: March 2023

p53-p21 cooperation in Calu-1 lung cancer cells
Supplementary Figure S2 from The p53/p21 Complex Regulates Cancer Cell Invasion and Apoptosis by Targeting Bcl-2 Family Proteins
Authors: Kim Eun Mi , Jung Chan-Hun , Kim Jongdoo , Hwang Sang-Gu , Park Jong Kuk , Um Hong-Duck
Published: March 2023

Bcl-XL is a target of the cooperative action of p53 and p21
SUPPLEMENTARY figure 5 from IGFBP2 Activates the NF-κB Pathway to Drive Epithelial–Mesenchymal Transition and Invasive Character in Pancreatic Ductal Adenocarcinoma
Authors: Gao Song , Sun Yan , Zhang Xuebin , Hu Limei , Liu Yuexin , Chua Corrine Yingxuan , Phillips Lynette M. , Ren He , Fleming Jason B. , Wang Huamin , Chiao Paul J. , Hao Jihui , Zhang Wei
Published: March 2023

Quantification of western blotting from main Figure 5.
Table S5 from MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy
Authors: Reinhardt Julia , Landsberg Jennifer , Schmid-Burgk Jonathan L. , Ramis Bartomeu Bibiloni , Bald Tobias , Glodde Nicole , Lopez-Ramos Dorys , Young Arabella , Ngiow Shin Foong , Nettersheim Daniel , Schorle Hubert , Quast Thomas , Kolanus Waldemar , Schadendorf Dirk , Long Georgina V. , Madore Jason , Scolyer Richard A. , Ribas Antoni , Smyth Mark J. , Tumeh Paul C. , Tüting Thomas , Hölzel Michael
Published: March 2023

Supplemental Table S5. Hallmark gene sets up in amelanotic BrafV600ExCdk4R24C melanomas versus pigmented BrafV600ExCdk4R24C melanomas (GSEA results).
Supplementary Materials from Genome-Wide CRISPR Screen for Essential Cell Growth Mediators in Mutant KRAS Colorectal Cancers
Authors: Yau Edwin H. , Kummetha Indrasena Reddy , Lichinchi Gianluigi , Tang Rachel , Zhang Yunlin , Rana Tariq M.
Published: March 2023

This file contains supplemental figure legends, supplemental table titles, and supplemental materials and methods.
Supplementary Figure 1 from PD-1 Expression in Head and Neck Squamous Cell Carcinomas Derives Primarily from Functionally Anergic CD4+ TILs in the Presence of PD-L1+ TAMs
Authors: Mattox Austin K. , Lee Jina , Westra William H. , Pierce Robert H. , Ghossein Ronald , Faquin William C. , Diefenbach Thomas J. , Morris Luc G. , Lin Derrick T. , Wirth Lori J. , Lefranc-Torres Armida , Ishida Eiichi , Chakravarty Patrick D. , Johnson Lauren , Zeng Yang C. , Chen Huabiao , Poznansky Mark C. , Iyengar Neil M. , Pai Sara I.
Published: March 2023

This file contains Supplementary Figure 1. Supplementary Figure 1 shows the staining pattern of tumoral PD-L1 staining.
Supplementary Table 3 from PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer
Authors: Hsu Jessie Hao-Ru , Hubbell-Engler Benjamin , Adelmant Guillaume , Huang Jialiang , Joyce Cailin E. , Vazquez Francisca , Weir Barbara A. , Montgomery Philip , Tsherniak Aviad , Giacomelli Andrew O. , Perry Jennifer A. , Trowbridge Jennifer , Fujiwara Yuko , Cowley Glenn S. , Xie Huafeng , Kim Woojin , Novina Carl D. , Hahn William C. , Marto Jarrod A. , Orkin Stuart H.
Published: March 2023

GSEA analysis of differentially expressed genes in the control versus Prmt1 KO mOS at the transcript level using hallmark gene sets.
Supplementary Figures and Legends from PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer
Authors: Hsu Jessie Hao-Ru , Hubbell-Engler Benjamin , Adelmant Guillaume , Huang Jialiang , Joyce Cailin E. , Vazquez Francisca , Weir Barbara A. , Montgomery Philip , Tsherniak Aviad , Giacomelli Andrew O. , Perry Jennifer A. , Trowbridge Jennifer , Fujiwara Yuko , Cowley Glenn S. , Xie Huafeng , Kim Woojin , Novina Carl D. , Hahn William C. , Marto Jarrod A. , Orkin Stuart H.
Published: March 2023

This file contains additional data supporting the role of Prmt1 in human OS maintenance and murine OS tumor initiation, as well as proteomics and RNA-seq data supporting the role of Prmt1 in translation regulation.
The list of PRC2 target genes and the result of microarray analysis from PRC2-Mediated Transcriptomic Alterations at the Embryonic Stage Govern Tumorigenesis and Clinical Outcome in MYCN-Driven Neuroblastoma
Authors: Tsubota Shoma , Kishida Satoshi , Shimamura Teppei , Ohira Miki , Yamashita Satoshi , Cao Dongliang , Kiyonari Shinichi , Ushijima Toshikazu , Kadomatsu Kenji
Published: March 2023

The table contains the list of PRC2 target genes created by Ben-Porath et al., and the result of microarray analysis for PRC2 components between E13.5 TH-MYCN spheres and E13.5 WT spheres.
Figure S4 from Quantitative Whole Genome Sequencing of Circulating Tumor Cells Enables Personalized Combination Therapy of Metastatic Cancer
Authors: Gulbahce Natali , Magbanua Mark Jesus M. , Chin Robert , Agarwal Misha R. , Luo Xuhao , Liu Jia , Hayden Daniel M. , Mao Qing , Ciotlos Serban , Li Zhenyu , Chen Yanxiang , Chen Xingpeng , Li Yuxiang , Zhang Rebecca Yu , Lee Katharine , Tearle Rick , Park Emily , Drmanac Snezana , Rugo Hope S. , Park John W. , Drmanac Radoje , Peters Brock A.
Published: March 2023

Copy number analysis based on read coverage in all batches. Read data is plotted starting from Chr1 and ending at ChrX. Each sample is labeled on the right side of the plot. All CTC samples identify chr1q amplification, and chr13 and chr16q losses.
A microarray analysis of RA (+) and (-) spheres from PRC2-Mediated Transcriptomic Alterations at the Embryonic Stage Govern Tumorigenesis and Clinical Outcome in MYCN-Driven Neuroblastoma
Authors: Tsubota Shoma , Kishida Satoshi , Shimamura Teppei , Ohira Miki , Yamashita Satoshi , Cao Dongliang , Kiyonari Shinichi , Ushijima Toshikazu , Kadomatsu Kenji
Published: March 2023

A microarray analysis of TH-MYCN spheres cultured in RA (+) and (-) medium. The table contains data processing, probe information, and the results of gene ontology analysis for differentially expressed genes.
Supplementary Methods and figure legends from S100A4 Is a Biomarker and Regulator of Glioma Stem Cells That Is Critical for Mesenchymal Transition in Glioblastoma
Authors: Chow Kin-Hoe , Park Hee Jung , George Joshy , Yamamoto Keiko , Gallup Andrew D. , Graber Joel H. , Chen Yuanxin , Jiang Wen , Steindler Dennis A. , Neilson Eric G. , Kim Betty Y.S. , Yun Kyuson
Published: March 2023

Supplementary figure legends for Supplementary Figures 1-3. In addition, supplementary Methods with detailed protocols and sequence information.
Figure S4 from Immune Checkpoint Blockade, Immunogenic Chemotherapy or IFN-α Blockade Boost the Local and Abscopal Effects of Oncolytic Virotherapy
Authors: Fend Laetitia , Yamazaki Takahiro , Remy Christelle , Fahrner Catherine , Gantzer Murielle , Nourtier Virginie , Préville Xavier , Quéméneur Eric , Kepp Oliver , Adam Julien , Marabelle Aurélien , Pitt Jonathan M. , Kroemer Guido , Zitvogel Laurence
Published: March 2023

Antitumor activity of WR in combination with immune checkpoint inhibitors
Supplemental Materials and Methods from Integrating Models to Quantify Environment-Mediated Drug Resistance
Authors: Picco Noemi , Sahai Erik , Maini Philip K. , Anderson Alexander R.A.
Published: March 2023

This file includes a detailed description of the methods used to obtain numerical solution of the equations, and method for the estimation of model parameters.
Figure S2 from Immune Checkpoint Blockade, Immunogenic Chemotherapy or IFN-α Blockade Boost the Local and Abscopal Effects of Oncolytic Virotherapy
Authors: Fend Laetitia , Yamazaki Takahiro , Remy Christelle , Fahrner Catherine , Gantzer Murielle , Nourtier Virginie , Préville Xavier , Quéméneur Eric , Kepp Oliver , Adam Julien , Marabelle Aurélien , Pitt Jonathan M. , Kroemer Guido , Zitvogel Laurence
Published: March 2023

Defective IFNAR signaling pathway does not facilitate OV replication in vitro
Figure S1 from Immune Checkpoint Blockade, Immunogenic Chemotherapy or IFN-α Blockade Boost the Local and Abscopal Effects of Oncolytic Virotherapy
Authors: Fend Laetitia , Yamazaki Takahiro , Remy Christelle , Fahrner Catherine , Gantzer Murielle , Nourtier Virginie , Préville Xavier , Quéméneur Eric , Kepp Oliver , Adam Julien , Marabelle Aurélien , Pitt Jonathan M. , Kroemer Guido , Zitvogel Laurence
Published: March 2023

WR treatment induces exposure of molecular patterns corresponding to immunogenic cell death
Supplemental Materials and Methods and Supplementary Figures 1 and 2 from Threshold Analysis and Biodistribution of Fluorescently Labeled Bevacizumab in Human Breast Cancer
Authors: Koch Maximilian , de Jong Johannes S. , Glatz Jürgen , Symvoulidis Panagiotis , Lamberts Laetitia E. , Adams Arthur L.L. , Kranendonk Mariëtte E.G. , Terwisscha van Scheltinga Anton G.T. , Aichler Michaela , Jansen Liesbeth , de Vries Jakob , Lub-de Hooge Marjolijn N. , Schröder Carolien P. , Jorritsma-Smit Annelies , Linssen Matthijs D. , de Boer Esther , van der Vegt Bert , Nagengast Wouter B. , Elias Sjoerd G. , Oliveira Sabrina , Witkamp Arjen J. , Mali Willem P.T.M. , Van der Wall Elsken , Garcia-Allende P. Beatriz , van Diest Paul J. , de Vries Elisabeth G.E. , Walch Axel , van Dam Gooitzen M. , Ntziachristos Vasilis
Published: March 2023

Supplemental Materials and Methods; Suppl. Fig. 1. Comparison of tumor vs. skin fluorescence obtained from human breast tissue specimen; Suppl. Fig 2: Magnified comparison between fluorescence images obtained from 3mm thick paraffin slices and 4microm paraffin slices.
Supplementary Table 3 from Transcriptional Selectivity of Epigenetic Therapy in Cancer
Authors: Sato Takahiro , Cesaroni Matteo , Chung Woonbok , Panjarian Shoghag , Tran Anthony , Madzo Jozef , Okamoto Yasuyuki , Zhang Hanghang , Chen Xiaowei , Jelinek Jaroslav , Issa Jean-Pierre J.
Published: March 2023

An excel file containing a list of primer sequences used for qPCR and pyrosequencing.
Supplementary Figure S1 from PD-1 Status in CD8+ T Cells Associates with Survival and Anti-PD-1 Therapeutic Outcomes in Head and Neck Cancer
Authors: Kansy Benjamin A. , Concha-Benavente Fernando , Srivastava Raghvendra M. , Jie Hyun-Bae , Shayan Gulidanna , Lei Yu , Moskovitz Jessica , Moy Jennifer , Li Jing , Brandau Sven , Lang Stephan , Schmitt Nicole C. , Freeman Gordon J. , Gooding William E. , Clump David A. , Ferris Robert L.
Published: March 2023

Supplementary Figure S1 shows identification of different subsets of PD1+ cells
Supplementary Information from Whole-Genome Sequencing Reveals Breast Cancers with Mismatch Repair Deficiency
Authors: Davies Helen , Morganella Sandro , Purdie Colin A. , Jang Se Jin , Borgen Elin , Russnes Hege , Glodzik Dominik , Zou Xueqing , Viari Alain , Richardson Andrea L. , Børresen-Dale Anne-Lise , Thompson Alastair , Eyfjord Jorunn E. , Kong Gu , Stratton Michael R. , Nik-Zainal Serena
Published: March 2023

This file contains the following Supplementary figures and Supplementary Material and Methods: Supplementary Figure 1: Contribution of base substitution signatures and indels in 640 breast cancer WGS. Supplementary Figure 2: Whole genome plots for 11 MMR deficient breast cancers Supplementary Figure 3: Genome plots for the two samples with germline PMS2 mutations. Supplementary Figure 4: Scatter plot demonstrating the relationship between total number of substitutions associated with the three MMR signatures 6, 20, and 26 and number of indels. Supplementary Materials and Methods 1. Mutational signatures background 2. Detection of MMR deficient cancers in other data sets 2.1 Detection of a genomic profile characteristic of PMS2 deficient tumours in Ovarian cancer. 2.2 Detection of MMR deficient breast cancers in WES
Supplementary Figure 3 from Anti-Jagged Immunotherapy Inhibits MDSCs and Overcomes Tumor-Induced Tolerance
Authors: Sierra Rosa A. , Trillo-Tinoco Jimena , Mohamed Eslam , Yu Lolie , Achyut Bhagelu R. , Arbab Ali , Bradford Jennifer W. , Osborne Barbara A. , Miele Lucio , Rodriguez Paulo C.
Published: March 2023

Figure showing representative and merged results of the depletion of MDSCs and MDSC-LC using anti-Gr-1 antibody.
Supplemental methods and figure legends from Glycerol-3-phosphate Acyltransferase 1 Promotes Tumor Cell Migration and Poor Survival in Ovarian Carcinoma
Authors: Marchan Rosemarie , Büttner Bettina , Lambert Jörg , Edlund Karolina , Glaeser Iris , Blaszkewicz Meinolf , Leonhardt Gregor , Marienhoff Lisa , Kaszta Darius , Anft Moritz , Watzl Carsten , Madjar Katrin , Grinberg Marianna , Rempel Eugen , Hergenröder Roland , Selinski Silvia , Rahnenführer Jörg , Lesjak Michaela S. , Stewart Joanna D. , Cadenas Cristina , Hengstler Jan G.
Published: March 2023

Full description of all methods used, legends for the supplementary figures, and references for the supplementary.
Supplemental Fig Legend from Cyclin D1 Restrains Oncogene-Induced Autophagy by Regulating the AMPK–LKB1 Signaling Axis
Authors: Casimiro Mathew C. , Di Sante Gabriele , Di Rocco Agnese , Loro Emanuele , Pupo Claudia , Pestell Timothy G. , Bisetto Sara , Velasco-Velázquez Marco A. , Jiao Xuanmao , Li Zhiping , Kusminski Christine M. , Seifert Erin L. , Wang Chenguang , Ly Daniel , Zheng Bin , Shen Che-Hung , Scherer Philipp E. , Pestell Richard G.
Published: March 2023

Figure legends for supplemental data.
Supplementary Data from PolyI:C and CpG Synergize with Anti-ErbB2 mAb for Treatment of Breast Tumors Resistant to Immune Checkpoint Inhibitors
Authors: Charlebois Roxanne , Allard Bertrand , Allard David , Buisseret Laurence , Turcotte Martin , Pommey Sandra , Chrobak Pavel , Stagg John
Published: March 2023

Data of memory response, single agent activity, tumor sizes at time of flow cytometry analysis and antibody-mediated cellular cytotoxicity of trastuzumab-treated BT-474 cells is shown.
Supplementary Figure 7 from Quantification of Pathway Cross-talk Reveals Novel Synergistic Drug Combinations for Breast Cancer
Authors: Jaeger Samira , Igea Ana , Arroyo Rodrigo , Alcalde Victor , Canovas Begoña , Orozco Modesto , Nebreda Angel R. , Aloy Patrick
Published: March 2023

Sigmoid-fitted dose-response curves generated for each of the experimentally validated drug combinations in the five cell lines.
Supplementary Material and Methods from NEMO, a Transcriptional Target of Estrogen and Progesterone, Is Linked to Tumor Suppressor PML in Breast Cancer
Authors: Elsarraj Hanan S. , Valdez Kelli E. , Hong Yan , Grimm Sandra L. , Ricci Lawrence R. , Fan Fang , Tawfik Ossama , May Lisa , Cusick Therese , Inciardi Marc , Redick Mark , Gatewood Jason , Winblad Onalisa , Hilsenbeck Susan , Edwards Dean P. , Hagan Christy R. , Godwin Andrew K. , Fabian Carol , Behbod Fariba
Published: March 2023

Description of additional experiments and procedures carried out in this study
Figure S2 from SOCS1 Gene Therapy Improves Radiosensitivity and Enhances Irradiation-Induced DNA Damage in Esophageal Squamous Cell Carcinoma
Authors: Sugase Takahito , Takahashi Tsuyoshi , Serada Satoshi , Fujimoto Minoru , Hiramatsu Kosuke , Ohkawara Tomoharu , Tanaka Koji , Miyazaki Yasuhiro , Makino Tomoki , Kurokawa Yukinori , Yamasaki Makoto , Nakajima Kiyokazu , Kishimoto Tadamitsu , Mori Masaki , Doki Yuichiro , Naka Tetsuji
Published: March 2023

This figure shows p53 status in ESCC cells and the effect of p53 rerated signals after irradiation and SOCS1 over expression. ESCC cells in this study harbored p53 mutation and p53-related response by IR and/or SOCS1 over expression was not observed in our study.
Table S2 from A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220
Authors: Hou Panpan , Wu Chao , Wang Yuchen , Qi Rui , Bhavanasi Dheeraj , Zuo Zhixiang , Dos Santos Cedric , Chen Shuliang , Chen Yu , Zheng Hong , Wang Hong , Perl Alexander , Guo Deyin , Huang Jian
Published: March 2023

Supplementary Table 2. The percentage of blast in all primary AML patient samples
Figure S4 from A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220
Authors: Hou Panpan , Wu Chao , Wang Yuchen , Qi Rui , Bhavanasi Dheeraj , Zuo Zhixiang , Dos Santos Cedric , Chen Shuliang , Chen Yu , Zheng Hong , Wang Hong , Perl Alexander , Guo Deyin , Huang Jian
Published: March 2023

Supplementary Figure 4. No off-target effects were observed at the predicted off-target sites in primary AML cells. (A) The off-target sites of SPRY3 sgRNA4 were predicted by UCSC human genome browser. (B) The transduced primary cells were collected for genomic DNA extraction and the predicted off-target site was PCR amplified. The PCR product of primary cells was cloned into a TA cloning vector by TOPO TA cloning kit and subjected to sequencing.
Supplemental Figure S5 from Sunitinib Stimulates Expression of VEGFC by Tumor Cells and Promotes Lymphangiogenesis in Clear Cell Renal Cell Carcinomas
Authors: Dufies Maeva , Giuliano Sandy , Ambrosetti Damien , Claren Audrey , Ndiaye Papa Diogop , Mastri Michalis , Moghrabi Walid , Cooley Lindsay S. , Ettaiche Marc , Chamorey Emmanuel , Parola Julien , Vial Valerie , Lupu-Plesu Marilena , Bernhard Jean Christophe , Ravaud Alain , Borchiellini Delphine , Ferrero Jean-Marc , Bikfalvi Andréas , Ebos John M. , Khabar Khalid Saad , Grépin Renaud , Pagès Gilles
Published: March 2023

Supplementary Figure S5. Overexpression of VEGFC correlated with reduced overall survival of RCC patients. Analysis of in silico available data bases (TCGA Research Network) showed that overexpression of VEGFC is associated with a poor prognosis.
Supplemental Figure S3 from Sunitinib Stimulates Expression of VEGFC by Tumor Cells and Promotes Lymphangiogenesis in Clear Cell Renal Cell Carcinomas
Authors: Dufies Maeva , Giuliano Sandy , Ambrosetti Damien , Claren Audrey , Ndiaye Papa Diogop , Mastri Michalis , Moghrabi Walid , Cooley Lindsay S. , Ettaiche Marc , Chamorey Emmanuel , Parola Julien , Vial Valerie , Lupu-Plesu Marilena , Bernhard Jean Christophe , Ravaud Alain , Borchiellini Delphine , Ferrero Jean-Marc , Bikfalvi Andréas , Ebos John M. , Khabar Khalid Saad , Grépin Renaud , Pagès Gilles
Published: March 2023

Supplementary Figure S3. Sorafenib stimulated VEGFC promoter activity, increased the VEGFC mRNA half-life and HuR and TTP bind the 3'UTR of VEGFC and VEGFA mRNA. Sorafenib-dependent induction of VEGFC expression is linked to increased transcription and mRNA stability. HuR and TTP directly bind to the VEGFC mRNA 3'UTR.
Supplemental Figure S2 from Sunitinib Stimulates Expression of VEGFC by Tumor Cells and Promotes Lymphangiogenesis in Clear Cell Renal Cell Carcinomas
Authors: Dufies Maeva , Giuliano Sandy , Ambrosetti Damien , Claren Audrey , Ndiaye Papa Diogop , Mastri Michalis , Moghrabi Walid , Cooley Lindsay S. , Ettaiche Marc , Chamorey Emmanuel , Parola Julien , Vial Valerie , Lupu-Plesu Marilena , Bernhard Jean Christophe , Ravaud Alain , Borchiellini Delphine , Ferrero Jean-Marc , Bikfalvi Andréas , Ebos John M. , Khabar Khalid Saad , Grépin Renaud , Pagès Gilles
Published: March 2023

Supplementary Figure S2. Cells resistant to sunitinib overexpress VEGFC. VEGFC mRNA and protein are overexpressed in sunitinib-resistant RCC cells. Such induction is linked to increased transcription and mRNA stability.
Table S3 from Spi-B–Mediated Silencing of Claudin-2 Promotes Early Dissemination of Lung Cancer Cells from Primary Tumors
Authors: Du Wei , Xu Xing , Niu Qing , Zhang Xuexi , Wei Yiliang , Wang Ziqiao , Zhang Wei , Yan Jun , Ru Yongxin , Fu Zheng , Li Xiaobo , Jiang Yuan , Ma Zhenyi , Zhang Zhenfa , Yao Zhi , Liu Zhe
Published: March 2023

Table S3, related to Figure 4: List of Spi-B-dependent genes categorized by biological function.