bluuebunny/crossref_metadata_2025 huggingface dataset:
Implementation of Corporate Social Responsibility from Multinational Company in Indonesia Based on Perspective of Human Rights
Authors: Alexander Giordio , Rahayu Mella Ismelina Farma , Gunadi Ariawan
Published: August 2023

Purpose: The purpose of this research is to identify the obstacles to implementing corporate social responsibility (CSR) based on a human rights perspective, particularly for multinational companies in Indonesia.
 
Theoretical Framework: At its narrowest, it refers to a framework for measuring and reporting company performance against economic, social, and environmental parameters.
 
Method: The research methodology involves a comprehensive analysis of relevant literature and Indonesian regulations pertaining to CSR and human rights. The analysis of Indonesian regulations focuses on understanding the legal framework and its strengths, weaknesses, gaps in relation to CSR and human rights.
 
Results and conclusion: The research recommends addressing these obstacles, such as learning from successful practices in other countries, unifying regulations, socializing new regulations, and establishing a penal and penal system to promote compliance. By setting out these recommendations, the study suggests that Indonesia can strengthen the scope of its CSR, promote responsible business activities and ensure compliance with CSR obligations.
 
Research implications: The findings of this research have implications for policymakers, businesses, and other stakeholders in understanding the challenges and potential solutions for improving CSR implementation in Indonesia. The research highlights the importance of considering human rights principles in CSR practices and emphasizes the need for effective regulations and enforcement mechanisms.
 
Originality/value: This research contributes to the existing literature by focusing on the intersection of CSR and human rights in the Indonesian context. By identifying obstacles and providing recommendations, the research offers insights that can help enhance CSR practices and protect human rights in the country.
Housing Glossary
Authors: Marella Sai Rama Raju , Thakur Khushboo , Raqib Khan Mohd
Published: August 2023

This glossary provides definitions of key terms commonly used in the field of housing. It facilitates understanding the basic terminologies of the Housing sector. This Glossary of terms is designed to provide a foundational vocabulary for anyone new to the field of Housing in India.
Application of Uplc/Ms/Ms Method for Dertermination of Sudan I in Chili Sauces
Authors: Kieu Hung Nguyen , Quang Hien Truong , Ngoc Hien Tran , Thi Thuy Linh Nguyen , Thi Ha Nguyen
Published: August 2023

This study was carried out to verify and evaluate a method to quantify the relative Sudan I color product using ultra-high performance liquid chromatography coupled with tandem massspectrometry (UPLC/MS/MS). Sudan I was extracted through an Oasis HLB 3cc Vac Cartridge solid phase extraction column 60 mg, after that quantified by UPLC/MS/MS. The program uses a C18 column (2.1 x 100 mm, 1.7 µm), the mobile phase is acetonitrile and water containing 0.1% formic acid, the flow rate is 0.4 ml/min. Running conditions of MRM (Multiple Reaction Monitoring) mode, select molecular ion fragment 249 amu. The verification results have good linearity, the limit of detection (LOD) and the limit of quantification (LOQ) of the analytical procedure are 1.17 and 3.72 ng/g, respectively. The Sudan I recovery efficiency ranged from 82.00-107.33% with the relative standard deviation (RSD) between 4.35-9.04%. Highly sensitive sample extraction procedure is suitable for the determination of Sudan I in food based on 4 ionic fragments characteristics, meeting the requirements of the decision 2002/657/EC of the common European community. The verified analytical procedure was applied to quantitatively identify Sudan I in 21 chili samples. The results showed that Sudan I was not detected in all analyzed samples. The analytical procedure of Sudan I in this study could be used for food safety testing.
An investigation into the socio-economic conditions of agricultural labourers in Thiruvalai Panchayat, Tamil Nadu, India
Authors: Devi S. , Selvi S. , Rabert G.
Published: August 2023

Agricultural progress is commonly considered as a prerequisite of economic development. While modern times associate economic growth with industrialization, it is widely acknowledged that a strong agricultural foundation is essential for industrialization to thrive. In developing economies, giving priority to agriculture is crucial to hasten economic advancement. Initially, agricultural operations were carried out by hired labourers. The Labour Enquiry Committee (1950-51) defined agricultural labourers as individuals who work for more than half of the total number of days in a year for wages. In the Indian society, agricultural labourers belong to the lowest rung of the socio-economic ladder, facing significant disadvantages such as low wages, poor working conditions, and irregular employment. Their earnings barely allow for a subsistence level of living, leading to hand-to-mouth existence. This paper aims to investigate the socio-economic conditions of agricultural labourers in the Thiruvali Panchayat, Sirkali Taluk, Mayiladuthurai District of Tamil Nadu. The study indicates that wages are remarkably low, and steps should be taken to ensure these workers earn a regular and fair income. It suggests implementing equal pay for equal work in both agriculture and non-agriculture sectors. Additionally, the implementation of the Mahatma Gandhi National Rural Employment Guarantee Act (MGNREGA) could assist agricultural labourers during the off-season, necessitating an increase in wages and the number of days of employment.
A LEI DE ACESSO À INFORMAÇÃO: UMA ANÁLISE CRÍTICA, À LUZ DA DOUTRINA
Authors: Santos Alexandre Magno Borges Pereira , Borges Alexandre Walmott , Valadão Júnior Valdir Machado
Published: August 2023

O ensaio tem por objetivo apresentar uma discussão teórica a propósito dos dispositivos da Lei de Acesso à Informação (LAI), à luz dos conceitos de capacidades estatais. A Lei de Acesso à Informação (Lei 12.527/2011) já está em vigor há mais de dez anos e tem por objetivo garantir o direito ao acesso à informação, previsto na Constituição Federal. Ela se aplica a todos os órgãos da administração pública direta e indireta (dos três poderes e do Ministério Público), às autarquias, fundações públicas, empresas públicas, sociedades de economia mista e demais entidades controladas direta ou indiretamente pela União, Estados, Distrito Federal e Municípios. Por sua vez, o termo capacidades estatais denomina um conjunto de competências, habilidades, processos e estruturas de que os órgãos estatais são dotados e que utilizam para a consecução de seus objetivos institucionais. Subdividem-se em diversas subcapacidades, que colocam em evidência diferentes abordagens do mesmo fenômeno. Dentre elas, há as subcapacidades estatais técnico-administrativa, político-relacional, coercitiva/militar e legal. Defende-se que há relação íntima entre a LAI e as capacidades estatais, particularmente no sentido de que estas são os instrumentos de concretização dos objetivos constitucionais para que aquela gere efeitos reais, na vida cotidiana, na prática dos cidadãos. De fato, por mais sofisticada que seja a arquitetura jurídica, sem a arquitetura político-social - qual seja, os mecanismos, procedimentos, habilidades, competências e estrutura necessários para que ela seja aplicada – resta-lhe o papel de letra morta.
CITRA TUBUH DAN FAKTOR PEMBENTUK CITRA TUBUH PEREMPUAN EMERGING ADULT YANG MENGALAMI KENAIKAN BERAT BADAN SIGNIFIKAN KETIKA REMAJA
Authors: Pramono Isabella , Rossalia Nanda
Published: August 2023

Women often receive comments about their bodies as they gain weight, which increases the risk of developing a negative body image and damage the identity formation process during adolescence. These obstacles will impact the emerging adulthood developmental stages. This study aims to describe body image and body image formation factors in emerging adult women who experienced significant weight gain from being underweight during adolescence. Qualitative research was conducted, involving three adult female participants aged 18-25 years, who were classified as underweight during adolescence, experienced significant weight gain, had either underweight or normal Body Mass Index (BMI), and had a negative body image based on the Multidimensional Body-Self Relational Questionnaire-Appearance Scales (MBSRQ-AS). The three participants were selected through purposive criterion sampling. Data was collected through semi structured interviews, which were then analyzed using thematic analysis. The results showed that all three participants were dissatisfied with specific body parts due to the desire to achieve their ideal body weight. This dissatisfaction affected theparticipants’ efforts to present themselves and control their weight. These views were formed from individual experiences during adolescence, which persisted into emerging adulthood and were greatly influenced by interpersonal factors and cultural socialization factors.
HUBUNGAN ANTARA WORK LIFE BALANCE DENGAN KEPUASAN KERJA PADA KARYAWAN SALES
Authors: Wirawan Sarah Ancella Rudfika , Sukmarani
Published: August 2023

Work life balance is a situation where employees can balance their work or work with other commitments through the freedom to use their working hours. One of the benefits of employees having a work life balance is increasing physical health, mental health and increasing job satisfaction. However, it turns out that most people when they enter the world of work lose balance in their lives. the results of interviews conducted by one of the researchers with several sales, so high the targets or demands as salesperson make them have to work hard even outside working hours so that they arereluctant to work and feel burdened by the responsibilities that have been assigned. This study aims to find out and analyze the relationship between the demands dimension and the resources dimension of work life balance with job satisfaction in sales. The sampling technique in this study was accidental sampling. This study uses a correlational quantitative research approach. Data was obtained from 195 salespeople who are domiciled in Indonesia using Fisher's (2009) WLB scale measurement tool adapted by Gunawan et al. (2019) and Spector's JSS (1997) which was adapted by Zulfikar (2016). The results showed that there was a significant negative relationship between demands and job satisfaction (r = -0.520; p = 0.000) and there was a strong positive significant relationship between the resourcesdimension and job satisfaction (r = 0.334 and p = 0.000). Further research results will be discussed in the research discussion.
UNPROTECTEDNESS OF HUMAN EXISTENCE AND THE TEMPORALITY OF SAFETY IN THE PHILOSOPHY OF MARTIN HEIDEGGER
Authors:   Surgut State University, Surgut, Russia, Lebed E. S.
Published: August 2023

The article explores the problem of human vulnerability and the question of temporal security in Martin Heidegger’s philosophy through a historical-philosophical and philosophical-anthropological analysis. The relevance of the topic is determined by the importance of security in the modern world and its philosophical analysis in the context of the philosopher’s work. In contemporary society, there are numerous threats and chal-lenges that can endanger human security, and it is therefore important to understand the philosophical aspects of this problem in order to more effectively combat it. It is important to note that Heidegger approached the problem of security from a unique philosophical perspective, based on his fundamental ontology and theory of time. This approach allows for a deeper understanding of the philosophical aspects of security and the interaction between humans and the world as a whole. For Heidegger, security does not mean the absence of risks, but rather the abil-ity to master one’s fears and anxieties and learn to live with them. The philosopher’s works note a complex and multifaceted meaning of the relationship to security. An important condition for solving the problem posed in the article is Heidegger’s exploration of the experience of fear and anxiety in everyday life, which he reveals in “Being and Time” (1927). Here, the philosopher highlights the main feature of human existence, which should be sought not in Being itself, but rather in everyday experiences, among which fear and anxiety are just a few examples. The aim of the article is to show how the concepts of vulnerability, anxiety, and fear regarding security are revealed in Martin Heidegger’s philosophical methodology. Another important aspect considered in the article is the relation¬ship between time and security in fundamental ontology. Temporal concepts such as past, present, and future play a key role in understanding security. For Heidegger, time is not simply a linear sequence of events, but rather a fundamental concept that determines our ability to understand our fears and anxieties. In conclusion, the impor¬tance and necessity of returning to the study of Martin Heidegger’s philosophy are emphasized, and the relevance of his views for contemporary philosophers and other researchers is underlined, as his understanding of human vulnerability and temporal security can help us better understand the complexity and uncertainty of our lives and learn to live in a world of dangers and risks. Finally, studying Heidegger’s philosophy can help in the search for answers to current philosophical questions, such as the relationship between human beings, the world, nature, technology, and science, and ways of overcoming the crisis of modern society.
Bloqueo canal de los aductores (ACB) más infiltración en el espacio entre la arteria poplítea y la cápsula posterior de la rodilla (IPACK) ACB y la infiltración periarticular de rodilla (PAI)
Authors: Sebastián Sebastián , Morra Jonnathan , Orellana Kenneth , Deganutti Luciano
Published: August 2023

Introducción: Los pacientes sometidos a RTR experimentan con frecuencia severo dolor en el período posoperatorio inmediato. Los bloqueos nerviosos periféricos, en el contexto de la analgesia multimodal, han sido el camino para mitigar el dolor, brindar confort y acelerar la recuperación funcional del paciente. Los bloqueos IPACK, ACB y PAI son técnicas descriptas para proveer una adecuada analgesia sin provocar debilidad muscular. Materiales y Métodos: Estudio experimental, prospectivo, randomizado con diseño doble ciego. Se estudiaron 100 pacientes sometidos a RTR durante el período 2020 a 2022 divididos en dos grupos de 50 pacientes respectivamente. El grupo 1 representado por el bloqueo IPACK+ACB y el grupo 2 por ACB+PAI. Se utilizó la escala analógica visual (EVA) para la evaluación del dolor. Se cuantificó los rescates de opioides, grado de satisfacción, rango de movimiento y distancia recorrida en el posoperatorio. Resultados: Ambos grupos fueron homogéneos en datos demográficos y duración de la cirugía. Los pacientes del grupo 1 requirieron menos rescates de opiodes (p = 0,02) y presentaron una estancia hospitalaria menor (p = 0,04). El factor tiempo evidenció diferencias estadísticas en la percepción del dolor (p = 0,001), pero no así el factor grupos (p > 0,05). No se obtuvieron diferencias significativas en cuanto a satisfacción general de las técnicas aplicadas, distancia recorrida ni del rango de movimiento evaluados entre las 24 y 48 h del posoperatorio. Conclusión: El bloqueo combinado ACB más IPACK mostró mejores resultados clínicos y funcionales para el abordaje de la analgesia postoperatoria en RTR.
Satisfacción de pacientes en servicio de anestesia fuera de quirófano. Aplicación Escala ISAS
Authors: Martínez González Paula , Mayorga Anaya Henry , Meléndez Héctor Julio , Andrea García Leydi , Ortega C. Cristhian
Published: August 2023

Introducción: Con el advenimiento de nuevas técnicas quirúrgicas, los procedimientos fuera de salas de cirugía han venido en aumento significativo. La satisfacción de los pacientes tras un acto anestésico es una medida de calidad de la asistencia que contribuye a la evaluación del centro sanitario. Objetivos: Describir la satisfacción, así como las características clínicas y sociodemográficas de los pacientes que fueron llevados a anestesia fuera del quirófano (AFQ) por medio de la aplicación de la Escala Iowa Satisfaction with Anesthesia Scale (ISAS). Materiales y Métodos: Se realizó un estudio analítico tipo corte transversal, en procedimientos de AFQ, Se incluyeron 145 pacientes mayores de 18 años a quienes se les aplicó la escala ISAS. Se realizó la evaluación de la escala en términos de validez, fiabilidad, consistencia interna y aceptabilidad. Resultados y Conclusiones: Todos los 145 pacientes recibieron sedación, el 92% fueron de gastroenterología. Se encontró una fiabilidad buena por un alfa de Cronbach de 0,76. Se hizo una evaluación del coeficiente de correlación de Pearson entre el resultado promedio de cada pregunta de la escala con la respuesta a la pregunta N°2 con evidencia en las preguntas de carácter positivo una validez convergente buena. El 95,17% se clasifico como “totalmente satisfecho” con la anestesia recibida, el medicamento más usado por los anestesiólogos fue el propofol en 93%. Se puede decir que la escala ISAS en los pacientes AFQ se puede usar para medir satisfacción de la anestesia.
Anestesia retrobulbar: Anestesia del tronco encefálico y parálisis del nervio craneal contralateral. Reporte de un caso
Authors: Armenteros Cortés Gracia , Martínez Torres Concepción , Ramos Arroyo Isabel , Rodríguez Archilla Ana
Published: August 2023

La anestesia retrobulbar se usa de forma rutinaria en la cirugía oftalmológica. Además de las complicaciones locales en el lugar de la inyección pueden surgir complicaciones sistémicas como parada cardiorrespiratoria, convulsiones así como afectación del ojo contralateral. Por lo tanto, la anestesia retrobulbar, aunque de forma infrecuente, puede asociarse a la aparición de manifestaciones neurológicas, principalmente por un mecanismo de difusión del anestésico local al espacio subaracnoideo. La presencia del anestesiólogo y monitorización continua del paciente, son requisitos indispensables ante la posibilidad de que maniobras de reanimación sean necesarias por afectación transitoria del anestésico a nivel del sistema nervioso central. Presentamos un caso de afectación troncoencefálica y paresia completa del III y IV par craneal en el ojo contralateral tras anestesia retrobulbar en un paciente varón de 50 años para cirugía programada de cataratas en régimen de cirugía mayor ambulatoria.
Os benefícios e as dificuldades da telemedicina como alternativa no acesso à saúde
Authors: Wanderley João Marcos Faria , Bastos Carla Santos , Silva João Marcos Luiz da , Freire Said Gabriel Campos , Morais Yasmim Pamella de Paula , Silva Constanza Thaise Xavier
Published: August 2023

Objetivo: Evidenciar quais os benefícios e as dificuldades da telemedicina como alternativa no acesso à saúde. Métodos: Revisão integrativa, nas bases de dados National Library of Medicine and National Institutes of Health (PubMed), Literatura Latino-americana e do Caribe em Ciências da Saúde (LILACS) e Periódicos da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). A busca foi realizada em outubro de 2022. Os descritores em Ciências da Saúde (DeCS) foram: telemedicina, acesso à saúde, atenção primária à saúde, inquéritos de saúde e seus correspondentes em inglês, com as combinações dos operadores booleanos AND e OR. Os critérios de inclusão foram: publicações em português e inglês, estudos originais de natureza primária, de livre acesso, disponibilizados na íntegra e publicados entre 2017 e 2022. Resultados: Após a aplicação dos critérios de inclusão e exclusão, foram selecionados 19 estudos. O presente estudo foi categorizado em benefícios e dificuldades. Considerações finais: Os pontos positivos que se destacam são a ampliação do acesso à saúde e a garantia da longitudinalidade e da resolutividade. Já as dificuldades foram a escassez de recursos humanos e estruturais, distanciamento entre médico e paciente e por fim a falta de afinidade com a tecnologia.
Sífilis gestacional: epidemiologia, patogênese e manejo
Authors: Almeida Beatriz Caroline Pazzini de , Lima Leonardo Portugal , Dias João Pedro Golçalves , Figueiredo Júnior Hélcio Serpa de
Published: August 2023

Objetivo: Revisar de forma clara e didática a epidemiologia, patogênese e manejo da sífilis gestacional (SG). Revisão bibliográfica: A sífilis gestacional é uma doença bacteriana sexualmente transmissível causada pelo Treponema Pallidum que afeta mulheres gravidas, quando não é tratada corretamente com, no máximo, trinta dias antes do parto, pode evoluir para transmissão vertical, causando sífilis congênita. É uma doença que atinge cerca de 1 milhão de gestantes todos os anos em todo o mundo e sua evolução pode cursar com aborto espontâneo, baixo peso as nascer, prematuridade, neurossífilis, malformações ósseas entre outras alterações que podem alterar significativamente a qualidade de vida do bebê. O tratamento da SG é feito preferencialmente com Penicilina G Benzatina 2,4 milhões de unidades intramuscular e a dose depende da fase da doença na qual a gestante se encontra. Considerações finais: A SG é uma patologia que requer rápido diagnóstico e início imediato do tratamento a fim de evitar a progressão da doença para suas formas mais graves e sífilis congênita.
Conhecimentos dos profissionais de saúde sobre o uso e orientação de indicações terapêuticas sobre as plantas medicinais
Authors: Araújo Kristiane Alves , Alves Ana Paula Barbosa , Repetto Maxim , Soares Juliana Pontes
Published: August 2023

Objetivo: Compreender a percepção dos profissionais da Atenção Primária à Saúde sobre a inserção da Fitoterapia no Sistema Único de Saúde (SUS) nas Unidades Básicas de Saúde (UBS) em dois bairros de uma cidade do estado Roraima. Métodos: Tratou de um estudo descritivo, exploratório, cujos referenciais metodológicos decorrem dos princípios da pesquisa qualitativa. Os participantes do estudo foram profissionais de saúde (n=20) das UBS. Resultados: Os participantes da pesquisa reconhecem a relevância da implantação da política das plantas medicinais e   fitoterapia nas práticas e cuidados de atenção primária à  saúde. Acreditam que seus conhecimentos não são suficientes para a correta prescrição e/ou orientação de fitoterápicos aos usuários; não tiveram em sua maioria na graduação uma disciplina ou módulo com abordagem a Fitoterapia, a maior parte percebe a fitoterapia como uma prática de saúde importante e veem como fator de dificuldade na implantação a questão do desconhecimento dos profissionais de saúde. Conclusão: Os profissionais de saúde precisam ter apoio para capacitação das Secretarias de Saúde Municipais e Estaduais para desenvolver projetos de fitoterapia na Atenção Primária em Saúde para prestar uma assistência com excelência e melhorar a qualidade dos seus usuários.
How mixed-breed dogs resolve the “horoscopes” surrounding dog breeds
Authors: Morrill Kathleen
Published: August 2023

Dog breeds are iconic, serving as familiar examples for how genetic selection can produce a diverse array of biological traits from appearance to physiology to behavior. Genome-wide analysis and large-scale surveys of companion dogs—pedigreed and mixed-breed—re-evaluates how much a dog’s breed genetically influences how they look and behave.
National (State) Bibliographic Resources on the Websites of National Libraries of the Subjects of the Russian Federation: State, Problems, Prospects
Authors: Trofimova Natalya I.
Published: August 2023

The article summarizes the results of monitoring of national (state) bibliographic resources on the websites of national libraries of the subjects of the Russian Federation. The peculiarities of the current national (state) bibliographic control in the republics of Russia are noted. The composition of the issues of state bibliographic indexes “Annals of the Press” by types of documents, differences in the periodicity of publishing, languages of the printed editions, included into “Annals”, presence of auxiliary indexes, as well as the form of presentation “Annals of the Press” (electronic editions, digitized printed editions, databases) are analyzed. The chronological framework of current and retrospective national (state) bibliographic indexes presented on the websites of national libraries of the subjects of the Russian Federation is determined.
Site-specific Deaminative Trifluoromethylation of Aliphatic Primary Amines
Authors: Wang Honggen , Xue Jiang-Hao , Li Yin , Liu Yuan , Li Qingjiang
Published: August 2023

The introduction of trifluoromethyl groups into organic molecules is of paramount importance in modern synthetic chemistry and medicinal chemistry. While methods for constructing C(sp2)-CF3 bonds have been well established, the advancement of practical and comprehensive approaches for forming C(sp3)-CF3 bonds remains considerably restricted. In this work, we describe an efficient and site-specific deaminative trifluoromethylation reaction of aliphatic primary amines to afford the corresponding alkyl trifluoromethyl compounds. The reaction proceeds at room temperature with readily accessible N-anomeric amide and bench-stable bpyCu(CF3)3 (Grushin’s reagent) under blue light. The protocol features mild reaction conditions, good functional group tolerance, and moderate to good yields. Remarkably, the method can be applied to the direct, late-stage trifluoromethylation of natural products and bioactive molecules. Experimental mechanistic studies were conducted, and a radical mechanism is proposed, wherein the dual roles of Grushin’s reagent have been elucidated.
Optimising excipient properties to prevent aggregation in biopharmaceutical formulations
Authors: King Toby , Humphrey James , Laughton Charles , Thomas Neil , Hirst Jonathan
Published: August 2023

Excipients are included within protein biotherapeutic solution formulations to improve colloidal and conformational stability, but are generally not designed for the specific purpose of preventing aggregation and improving cryoprotection in solution. In this work, we have explored the relationship between structure and anti-aggregation activity of excipients by utilising coarse-grained molecular dynamics modelling of protein excipient interaction. We have studied human serum albumin as a model protein, and report the interaction of 41 excipients (polysorbates, fatty alcohol ethoxylates, fatty acid ethoxylates, phospholipids, glucosides, amino acids, and others) in terms of the reduction of solvent accessible surface area of aggregation-prone regions, proposed as a mechanism of aggregation prevention. Polyoxyethylene sorbitan had the greatest degree of interaction with aggregation-prone regions, decreasing the solvent accessible surface area of APRs by 20.7 nm2. Physicochemical descriptors generated by Mordred are employed to probe the structure-activity relationship using partial least squares regression. A leave-one-out cross-validated model had a root mean square error of prediction of 4.1 nm2. Generally, longer molecules with a large number of alcohol-terminated PEG units tended to interact more, with qualitatively different protein interaction, wrapping around the protein, and would have a lesser protective effect on stability. Shorter or less ethoxylated compounds tend to form hemimicellar clusters at the protein surface. We propose that an improved design would feature many short chains of five to ten PEG units in many distinct branches and at least some hydrophobic content in the form of medium-length or greater aliphatic chains (i.e., six or more carbon atoms). The combination of molecular dynamics and quantitative modelling is an important first step in an all-purpose protein-independent model for the computer-aided design of stabilising excipients.
SAXS/PCS study on the mesoscopic structure of lipid nanoparticle (LNP) formulations for mRNA drug delivery: Comirnaty and drug-free LNP dispersions
Authors: Unruh Tobias , Götz Klaus , Vogel Carola , Fröhlich Erik , Scheurer Andreas
Published: August 2023

Lipid Nanoparticles (LNPs) produced by anti-solvent precipitation (ASP) are used in formulations for mRNA drug delivery. The mesoscopic structure of such complex multicomponent and polydisperse nanoparticulate systems is most relevant for their drug delivery properties, medical efficiency, shelf-life, and possible side effects. However, the knowledge on the structural details of such formulations is very limited. Essentially no such information is publicly available for pharmaceutical dispersions approved by numerous medicine agencies for the use in humans and loaded with mRNA encoding a mimic of the spike protein of the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) as e.g. the Comirnaty formulation (BioNTech). Here, we present a simple preparation method to mimic the Comirnaty drug-free LNPs including a comparison of their structural properties with those of Comirnaty. Strong evidence for the liquid state of the LNPs in both systems is found in contrast to the designation of the LNPs as solid lipid nanoparticles by BioNTech. A detailed structural model for the LNPs i.a. revealing their unexpected narrow size distribution will be presented based on SAXS, DLS, light microscopy, and ¹HNMR studies. The presented results should contribute to better understanding the LNP drug delivery process, enhancing their medical benefit, and reducing side effects.
Esquistossomose, geo-helmintíases e condições sanitárias na América Latina e Caribe: uma revisão sistemática
Authors: Santos Mariana Cristina Silva , Heller Léo
Published: August 2023

Objetivo.

Investigar a relação entre prevalência de esquistossomose e geo-helmintíases e variáveis de acesso a água, esgotamento sanitário e resíduos sólidos em países da América Latina e Caribe (ALC).

Métodos.

Realizou-se uma revisão sistemática nas bases de dados LILACS, PubMed, Web of Science e SciELO. Foram incluídos estudos publicados entre 1950 e agosto de 2021, com desenho ecológico e foco em agregados populacionais (estados, municípios e/ou distritos), tendo como desfecho primário a prevalência da infecção por Schistosoma mansoni, Ancylostoma sp., Necator americanus, Ascaris lumbricoides ou Trichuris trichiura e como variável explicativa o acesso a água, esgotamento sanitário e/ou resíduos sólidos. Foram considerados artigos com disponibilidade de texto completo e acesso livre nos idiomas inglês, espanhol ou português. O risco de viés e a qualidade dos estudos foram avaliados conforme o manual do Instituto Joanna Briggs.

Resultados.

De 2 714 artigos, nove foram elegíveis, publicados entre 1994 e 2021 e cobrindo 22 países da ALC e 14 350 municípios. A qualidade metodológica de todos os artigos foi moderada. As variáveis ambientais apontaram associação de abastecimento de água e coleta de resíduos sólidos com esquistossomose; abastecimento de água com ascaridíase, tricuríase e ancilostomíase; e de esgotamento sanitário com ascaridíase e ancilostomíase. Exceto por um artigo com abrangência regional para ALC, todos os demais foram desenvolvidos no Brasil.

Conclusão.

Evidencia-se a necessidade de ampliar a pesquisa sobre a associação entre condições sanitárias domiciliares e coletivas e doenças parasitárias para todos os países endêmicos da ALC para embasar estratégias ambientais para controle dessas doenças.
Using mixed methods to understand and tackle barriers to accessing health services
Authors: Houghton Natalia , Bascolo Ernesto , Coitiño Andrés , Koller Theadora S. , Fitzgerald James
Published: August 2023

This report describes the experience and lessons learnt from designing and implementing a combined quantitative and qualitative method to assess barriers to accessing health services. This approach was developed to study barriers to access in five dimensions: availability; geographical, financial, and organizational accessibility; acceptability; contact; and effective coverage. The study design was used in six countries in the World Health Organization Region of the Americas. The findings highlight the importance of having a well defined analysis framework and the benefits of adopting a mixed-methods approach. Using existing data and contextualizing findings according to specific population groups and geographical areas were essential for relevance and utilization of the study outcomes. The findings demonstrate the feasibility of using mixed methods to understand the complexity of access problems faced by different subpopulations. By involving decision-makers from the beginning and allowing flexibility for sustained discussions, the analysis and findings had an impact. The engagement of health authorities and key stakeholders facilitated the use of the findings for collaborative identification of policy options to eliminate access barriers. Lessons learnt from the study emphasized the need for active participation of decision-makers, flexibility in the process, and sustained opportunities for discussion to ensure impact. Giving consideration to local priorities and adapting the methods accordingly were important for the relevance and use of the findings. Future efforts could consider incorporating mixed methods into national and local monitoring and evaluation systems.
Value Universitas dan Perilaku Cyber Cheating: Analisis Teori Fraud Diamond
Authors: Basot Falentine Yessyani , Yuanita Dielanova Wynni , Dewi Christine Novita
Published: August 2023

The purpose of this study is to examine the factors that drive accounting students to commit academic fraud based on the fraud diamond theory (pressure, opportunity, rationalization and ability) and technology abuse by considering university values. This study used purposive sampling as a sampling method using a questionnaire. The sample of this research was 170 Bachelor of Accounting students at Christian Private University, Yogyakarta. The data analysis method was processed using the Structural Equation Model (SEM). Specifically, the SEM method chosen is Partial Least Square (PLS) because it can be used to analyze data with a small number of samples (Hair et al, 2014). The results of this study succeeded in proving that pressure, opportunity, rationalization, ability and misuse of technology have a significant positive effect on academic cheating. This revealed that students who study at universities with Christian values still separate spiritual interests and academic achievements.
FORMATION OF PATRIOTIC AND INTERCULTURAL EDUCATION THROUGH AN INNOVATIVE EDUCATIONAL PROJECT „TRAVEL WITH US AROUND BULGARIA AND EUROPE“
Authors:   Kindergarten „Zname na mira“, Vratsa, Georgieva Ralitsa , Nenovska Krasimira ,   Kindergarten „Zname na mira“, Vratsa
Published: August 2023

The article presents a five-month educational project that is different and goes beyond the framework of Bulgarian preschool education, which aims to develop key competences for lifelong learning – communication in the native language, recognition of foreign languages, basic knowledge in the field of natural sciences, skills for learning, social and civic competences, cultural awareness, and creative performances. At its core, it aims to satisfy children’s desire for new knowledge, beyond the state educational standards for preschool age. Combining an author’s program system and the method of Dr. Maria Montessori, as well as innovative educational practices from other European countries, we managed to intertwine intercultural and patriotic education, the involvement of parents in the educational process, and diverse teaching methods to satisfy this interest in children of the XX century.
MINI PROJECT „NATURE AND ITS FAIRY WORLD“
Authors:   Kindergarten „Kalina Malina“, Rakevo, Mladenova Milena , Tsenova Tsvetelina ,   Kindergarten „Kalina Malina“, Rakevo
Published: August 2023

Ecological education is a new direction of preschool pedagogy, which differs from the traditional – familiarization of children with nature. Early childhood is the period of formation of the foundations of the future personality. This is the most suitable moment from which work should begin to create a caring attitude to nature, to its beauty and uniqueness, to our common home. Ecology in kindergarten is not science, but the child’s relationship with nature. However, not all people understand our dependence on the environment, on water, air, soil and biodiversity. Ecology in kindergarten is not science, but the child’s relationship with nature. On the territory of our small villages, the residents face environmental problems, such as air pollution, deforestation and water and soil pollution. For this reason, during the school year, we, the teachers from DG „Kalina Malina“, set ourselves the task of showing the children how important it is to get to know, love and protect their surroundings. Many of them attending the kindergarten have a lower social status and this is of particular importance for their future development. DG „Kalina Malina“ is divided into five groups that are located in different settlements. That’s why, by including the children in the implementation of the activities set in the project, we also unite them into a whole, thus developing a sense of responsibility and teamwork.
SOCIALIZATION OF THE CHILDREN AT THE KINDERGARTEN USING MARIA MONTESSORI`S METHOD
Authors:   Kindergarten „Evropeicheta“, Vrarsa, Tzvetanova Plamena , Colova Violina ,   Kindergarten „Evropeicheta“, Vrarsa, Danova Dochka ,   Kindergarten „Evropeicheta“, Vrarsa
Published: August 2023

The problem of successful socialization will always be relevant, because it depends on how children will grow up, whether they will be successful, happy, good, what kind of people will surround them, whether they will be able to cope with the difficulties that have arisen. The acquisition of social skills and the formation of moral values begins from the first day in the kindergarten, because the child goes through a huge path in his individual development during childhood. The preschool age, like no other, is full of very important achievements in the socialization of children. It is at preschool age that children learn to control their own emotions and gain experience in practical thinking in terms of imagery and subject matter. Children develop voluntary control over behavior and their own actions. At the age of six, preschool children of social cognition are firmly fixed in such a position as „I and society“.
ART PROJECTS IN PHYSICS AND ASTRONOMY EDUCATION IN 9TH AND 10TH CLASS
Authors:   First English Language High School, Sofia, Mincheva Dimitrinka
Published: August 2023

Modern trends for more and more visualization and interactivity, both in educational and scientific literature and resources, as well as in the educational process, lead to new ideas and approaches in education at different levels. This text presents an author’s approach for innovative practices in the teaching of physics and astronomy in the 9th and 10th grades, where the possibilities of visual arts and technologies are a means of fulfilling creative projects in the field of both sciences. These practices took place at the First English Language High School in Sofia. The report presents and analyses art projects made by 9th and 10th grade students which have been aimed at 5th to 7th grade students. This approach, on the one hand, provokes a greater interest in the subjects included in the compulsory curriculum of physics and astronomy, on the other hand, it develops creativity and opportunities for realising creative ideas and skills with the help of innovative technologies.
THE FAIRY TALE AS A MEANS OF OVERCOMING BEHAVIORAL DISORDERS IN ELEMENTARY SCHOOL STUDENTS
Authors:   New Bulgarian University, Sofia, Tsanova Ekaterina
Published: August 2023

The fairy tale is a literary form with an extremely wide application in the educational process. In elementary school students, the fairy tale forms literary competences and is an important tool in artistic education. In the present report, the attention is focused on a less studied aspect – the educational influence of the fairy tale on behavioral disorders in elementary school students. The report briefly analyzes the difference between fairy tale therapy and the application of fairy tales in art pedagogy. Different art-pedagogical techniques were analyzed, in which the magical tale is used as a means to overcome behavioral disorders in elementary school students.
FORMATION OF VIRTUES – GENEROSITY
Authors:   First Primary School „St. Cyril and St. Methodius“, Gotse Delchev, Dinev Iliya
Published: August 2023

It is important to form practical knowledge and skills for communication and personal development of children at school by encouraging the positive qualities of their character on the one hand, and dealing with conflict situations and suppressing aggression on the other. This can be done through practical tools for dealing with negative phenomena and creating a school environment that encourages and values virtues by motivating their conscious understanding and application in the daily life of students. For this reason, Mr. Dinev and Mrs. Dineva, teachers at the First Primary School, decided to make and implement a binary lesson on the formation of virtues on the topic: „Generosity-basic human virtue“. The lesson offers concrete steps to encourage students to develop their noble qualities in this case – generosity, to look at themselves and look for what is truly valuable in their hearts and thus to have more understanding, empathy and patience when communicating with others. Kindness practice that we present is realized in 3rd grade and 5th grade in First Primary School „St. St. Cyril and Methodius“, Gotse Delchev.
IN THE WORLD OF CHILDREN’S BOOKS- AN INTERDISCIPLINARY LESSON IN FIRST GRADE
Authors:   First Primary School „St. Cyril and St. Methodius“, Gotse Delchev, Adamova Suzana
Published: August 2023

The lesson „In the world of children’s books“ is a kind of continuation of the topic „In the world of books“, which is studied in the first grade in the Bulgarian language and literature classes. The knowledge acquired in literature was successfully combined in the Interest Activities classes, where the little students showed how interesting and vast the world of books is, and together with that they made their first bookmarks to help them with reading. Apart from Bulgarian Language and Literature, other subjects – Music, Information Technology, Technology and Entrepreneurship found place in the lesson, making it interdisciplinary. I chose this topic to emphasize the importance of reading books at a very young age, and my goal was to help young students love books even more because reading books instills many virtues in us- it teaches us patience, curiosity, confidence, creativity, kindness, tolerance and empathy.
Exploring Social Contracts: Enhancing Cooperation and Collaboration between Businesses and Communities
Authors: Khairandy Ridwan , Barkatullah Abdul Halim , Huda M. Khoirul , Ariyanto . , Amir Ari Yusuf
Published: August 2023

Even though the term “social contract” has been around for a while, its definition has evolved to fit the circumstances in a particular region. This study examines the idea of social contracts in the dynamic Indonesian environment, with a focus on partnerships between businesses and communities. This study examines the changing social dynamics within Indonesian society by using a qualitative research methodology and conducting a thorough literature review. It investigates how social contracts can address problems with cooperation and interaction between various groups. The findings underscore two significant factors that influence social contracts: coordination challenges within the same group and competition challenges between different groups. To effectively address these challenges, it is crucial to comprehend both intra-group and inter-group dynamics. The study concludes by discussing the Indonesian perspective on social contracts within the framework of existing rules and regulations, emphasizing the necessity of raising awareness and establishing a well-defined social contract framework to promote inclusive development and social harmony. It is necessary to create awareness about how social contracts help maintain inclusive development and the need to live within the means of social harmony based on social contracts established with a clear framework to realize a peaceful society. This study offers valuable insights into Indonesia’s evolving concept of social contracts. It underscores the pivotal role of collaboration between companies and communities in adapting to the rapidly changing Indonesian environment. Doi: 10.28991/HEF-2022-03-04-005 Full Text: PDF
THE PROFESSION OF TEACHING. NEW FORMS OF PATRIOTIC EDUCATION OF SCHOOLCHILDREN
Authors:   Russian State University for the Humanities, Bulanova Marina B.
Published: August 2023

The article is about studying the new forms for patriotic education of schoolchildren in connection with the challenges of the launched special military operation (SVO) in Russia. The author shows that patriotic work is a traditional part of educational work in schools, however, it has changed in the current context. The first innovation was the performance of the Russian anthem and the raising of the flag, as well as the holding of “Conversations about the Important” in the classroom format. Work has begun on the preparation for publication of a new history textbook, which will include topics related to the current situation in the world. Another innovation at the school will be the inclusion of basic military training in the program of the subject “Fundamentals of Life Safety” (OBZh). The article presents the monitoring data of the Public Opinion Foundation FOM, which studied the attitude of Russians to new trends in school. Based on the analysis of the media, the author shows the attitude of Moscow teachers to the lesson “Talk about the Important” and the spread of patriotism practices among schoolchildren near Moscow. She concludes by stating that Russian teachers have a new mission – the education of effective patriotism among schoolchildren, but at the same time, physical and emotional stress has increased while all that for the same wages, which can reduce the attractiveness of the profession in the eyes of Russians.
WOMEN AND FEMINISM IN THE MODERN POLITICAL PROCESS
Authors:   St. Petersburg State University, Ushakova Valentina G.
Published: August 2023

The article gives a brief description of the basic theories of feminism, analyzes the activities of a historically unprecedented number of women in the political process and public administration of modern European societies. Special attention is paid to the processes of ideologization and politicization of radical feminist concepts. Postmodern, globalist concepts of radical feminism destroy the traditional system of values based on the concept of complementarity of masculinity and femininity, which leads to anti-feminism, post-feminism. The radical feminist positions of women politicians in modern European societies allow concluding that the traditional gender principle “Men = war, women = peace” has collapsed