bluuebunny/crossref_metadata_2025 huggingface dataset:
A rare case of gastric outlet obstruction in a patient with multiple myeloma
Authors:   Department of Gastroenterology, Kantonsspital St.Gallen, Switzerland., R Haeuptle
Published: May 2022

Gastric amyloidosis is a very rare cause of gastric outlet obstruction. Therefore, general treatment recommendations are missing. A 61-year-old man with multiple myeloma and cast-nephropathy with suspected manifestation of amyloidosis was admitted for gastroscopy because of nausea and emesis. Video fluoroscopy demonstrated a gastric outlet obstruction with subtotal stenosis of the pylorus. Gastric amyloidosis (AL-amyloid) was confirmed histologically by deroofingbiopsies which was consistent with the clonotype of the patient’s myeloma. Botox injection was ineffective for control of symptoms. Therefore, endoscopic balloon-dilatation (15 mm to 20 mm) was performed with a long-lasting clinical response of 3 to 6 months.
Neurological injury after transforaminal epidural steroid injection: Rare complication or natural progressive neurological deficit?
Authors:   Department of Anesthesiology, Intensive Care Medicine, Emergency Medicine and Multidisciplinary Pain Center, Ziekenhuis OostLimburg, Genk, Belgium., K Van Boxem , R Vervoort ,   Department of Anesthesiology, Intensive Care Medicine, Emergency Medicine and Multidisciplinary Pain Center, Ziekenhuis OostLimburg, Genk, Belgium., L Hendrix ,   Department of Anesthesiology, Intensive Care Medicine, Emergency Medicine and Multidisciplinary Pain Center, Ziekenhuis OostLimburg, Genk, Belgium., T Daenekindt ,   Department of Neurosurgery, Ziekenhuis Oost-Limburg, Genk, Belgium, D Mesotten ,   Department of Neurosurgery, Ziekenhuis Oost-Limburg, Genk, Belgium, J Van Zundert ,   Department of Anesthesiology and Pain Management, University Medical Centre Maastricht, Maastricht, The Netherlands.
Published: May 2022

Transforaminal epidural corticosteroid injections (TFESI) are widely used for subacute lumbosacral radicular pain and are typically applied during the time frame of potential evolution to neurological complications. We present a case report of a patient with lumbar spinal canal stenosis who developed a cauda equina syndrome (CES) after lumbar TFESI requiring emergency decompression. Lumbosacral radicular pain usually has a positive evolution. Some pitfalls may mask progressive neurological deterioration and obscure the causal relation with an epidural corticosteroid injection. An intake consultation with the patient’s informed consent and information on red flags before the procedure is required. If neurological deterioration occurs after a lumbar TFESI, it is sometimes impossible to discriminate the added effect of TFESI to the ongoing progression of neurological deficit. In patients with spinal canal stenosis, the injected volume should preferentially be small to minimize a possible increase in epidural pressure.
Conservative management for fetal megacystis: A clinical based approach
Authors:   Department of Obstetrics and Gynecology, Bugando Medical Centre, Catholic University of Health and Allied Sciences, Tanzania., Hassan Lisa , Kiritta Richard ,   Department of Obstetrics and Gynecology, Bugando Medical Centre, Catholic University of Health and Allied Sciences, Tanzania., Chuma Clotrida ,   Department of Obstetrics and Gynecology, Bugando Medical Centre, Catholic University of Health and Allied Sciences, Tanzania., Ndaboine Edgar ,   Department of Obstetrics and Gynecology, Bugando Medical Centre, Catholic University of Health and Allied Sciences, Tanzania., Hokororo Adolphine ,   Department of Paediatrics and Child Health, Bugando Medical Centre, Catholic University of Health and Allied Sciences, Tanzania., Kihunrwa Albert ,   Department of Obstetrics and Gynecology, Bugando Medical Centre, Catholic University of Health and Allied Sciences, Tanzania.
Published: May 2022

Background: Fetal megacystis is an enlargement of the fetal urinary bladder that is a rare ultrasonography finding during routine antenatal screening. Though intrauterine genetic screening is widely used to determine the prognosis of this condition in resource rich settings, in the developing world, clinician often has to rely on clinical judgement for proper counselling and management of women with such foetal presentations. Case presentation: We present a case of a 31 years old lady who presented at our facility as a referral case at a gestational age of 25 weeks for termination of pregnancy due to an incidental ultrasonography finding of an enlarged fetal urinary bladder with oligohydramnious. Initial evaluation at our facility led to diagnosis of foetal megacystis with no other congenital anomalies. An informed expectant management was carried out under close follow up and finally delivered a 4.2 kg baby by caesarean section at 39 weeks. The baby is currently 4months of age, with normal renal function parameters on routine care and urological follow up. Conclusion: Foetal megacystis is a rare condition with diverse aetiology. Genetic screening for chromosomal anomalies is a major prognostic indicator however in resource limited setup, a clinician has to rely on clinical judgement to provide the patient with the necessary information to make an informed decision between expectant management or termination of pregnancy.
Mixed methodology approach for ergonomic and multiphysical characterisation of metamaterials
Authors: Fusaro Gioia
Published: May 2022

Metamaterials have paved so far the way towards higher freedom of design of building’s features as their
physical characteristics depend on the geometry rather than the constituent material. At this point, the
research has reached an overall assessment of such innovative materials and applications are now arising
within the engineering field. However, many building engineering applications have to address multiple
physical constraints and mechanical responses while being tailored for ergonomic management by the final
users. At this moment there is no clear indication of how these systems may interact with i) different
environmental conditions and ii) different indoor and outdoor functions of the building. In this talk, I will first
highlight our recent work to draw a new experimental method outlying the impact of metamaterials on the
user’s perception through both ergonomics, psychoacoustics, and soundscape. In the second part of the
presentation, I will introduce a new method in development to include different environmental conditions
(in terms of temperature for example) to this ergonomic/human perception approach. Such methods could
be used to make metamaterials more affordable from the engineers, designers, industries, and users’ point
of view with a significant improvement in the industrial design applicability.
Antecedents and consequences of trust as a multidimensional construct. Cross-country analysis in the luxury retail sector
Authors:   Departamento de Administración, Facultad de Administración y Economía, Universidad de Santiago de Chile (Chile). Avda. Libertador Bernardo O`Higgins, 3363. Santiago – enrique.marinao@usach.cl, Marinao-Artigas Enrique , Valenzuela-Fernández Leslier ,   Departamento de Administración, Facultad de Economía y Negocios. Universidad de Chile (Chile). Diagonal Paraguay, 257. Santiago - lvalenzu@fen.uchile.cl, Chasco Coro ,   Department of Applied Economics, Universidad Autónoma de Madrid (Spain). C/ Francisco Tomás y Valiente 5, 28049 Madrid - coro.chasco@uam.es, Laroze-Prehn Denise ,   Departamento de Administración, Facultad de Administración y Economía. Universidad de Santiago de Chile (Chile). Avda. Libertador Bernardo O`Higgins, 3363. Santiago - denise.laroze@usach.cl
Published: May 2022

The objective of this study is to understand the role of the multidimensional trust of a luxury brand as an antecedent of consumer satisfaction and a consequence of reputation and familiarity, considering -in turn- that reputation and familiarity can be a consequence of the consumer’s cognitive and affective experiences. A cross-country analysis in the luxury retail sector was carried out. Association relationships between variables are tested by a model of structural equations. For this, a transnational analysis has been carried out in the luxury retail sector. A non-probabilistic sample was used in this study. 1058 people were interviewed, 608 consumers in Santiago (Chile) and 450 in Madrid (Spain). The key role played by the multidimensional trust of a luxury brand as an antecedent of satisfaction and consequence of reputation and familiarity is confirmed. When observing the reputation and familiarity of a luxury brand as a result of the cognitive and affective experiences of the consumer, differences between Chile and Spain have been discovered. Managers can not only use the brand’s own characteristics to differentiate themselves from the competition, but they can also do so through the multi-dimensional trust of the luxury brand.
The First Lady: Celebrating the Library Career of Louise Ferguson Bolden
Authors: Sarratt Carla
Published: April 2022

From its inception in 1869, Cleveland Public Library (CPL) solidified its mark in library history with the development of resources and practices that have been implemented by other library systems throughout the world. In 1940, when Louise Cornelia Ferguson Bolden made front-page news in the Cleveland Call and Post, the tide shifted for Black librarianship in Cleveland, Ohio. Her historic forty-six-year career in library science includes being the first Black student to graduate from Case Western Reserve University Library Science School and the first Black librarian at CPL. The Cleveland Call and Post, her personnel file, and annual reports provide a treasure trove of information about Bolden’s career as well as the state of the library and the city of Cleveland. Her career as a librarian not only expands the history of the library, but also tells the history and anthropology of the people in the community.
Analysis of the selection of the auxiliary drive system for a special purpose hybrid rail vehicle
Authors: Urbański Patryk , Gallas Dawid , Stachowicz Arkadiusz , Jakuszko Wojciech , Stobnicki Paweł
Published: May 2022

Strict emission standards mean that the internal combustion engines used in means of transport must meet the standards for the emission of harmful compounds. For this reason, there is an increase in the use of alternative sources of propulsion, including rail transport. The article presents unconventional solutions of drive systems in rail vehicles using hybrid systems and fuel cells. The concept of the realizing project of a special-purpose rail vehicle, which is to be able to be driven from three different sources, was presented. Considerations concerning the selection of the internal combustion propulsion system, which is to be used as an auxiliary in the vehicle, are described. The possibilities of installing the power unit on the vehicle were also presented.
SUGAR INDUSTRY: PRODUCTION, CONSUMPTION, AND WASTE UTILIZATION TO ENHANCE CLEANER PRODUCTION IMPLEMENTATION IN INDONESIA
Authors: FARAHDIBA AULIA ULFAH , JAR NANIK RATNI , QONITA ANIS ZUSRIN , AMALIA AUSSIE , WANTOPUTRI NOVIANI IMA
Published: April 2022

Cleaner production is referred to as a technical preventative procedure. Every step, every significance of information process, as well as every procedure and choices made, is analyzed. The Indonesian government has advocated this model in every critical industry, including the sugar industry. This research provides a picture of the sugar industryâs environmental impacts. In a sugar refinery, proper technology and management develop in reducing, recycling, and reusing become a zero waste. As a result, the sugar industry is considered an emission-free system. This study implies that sugar processing has issues that require careful management to eager the cleaner production. Environmental impact assessment (EIA) with Life Cycle Assessments (LCA) methodology could be the promising analysis of the solutions to develop the assessment in sugar refinery performances.
Organization of Developmental Training in Preschool Educational Institutions
Authors:   Azerbaijan State Pedagogical University, Bakhishova Sharafat
Published: May 2022

Self-realization, self-presentation is one of the most important qualities of the modern man. It is especially important to support this work in the educational process, bringing it to the centre of educators and children’s activities. One important way of doing this is to give tasks that ensure independence of thought. It is possible to ensure and monitor the development of children through classwork. The children demonstrate skills such as understanding, application, analysis, etc. at different stages of cognition. An important condition in the lesson content is the development of a humane position in children, situation selection for children, creative search, problem-solving, communication and cooperation skills in training, a reflection of self-regulation, self-awareness, reflection, selection of methods that allow children to develop cognitive activity. Methods of raising cognitive activity include comparison, analysis, generalization, question method, solution of logical tasks, research, etc.
Humane Education – Benefits and Challenges
Authors:   Trakia University – Stara Zagora, Arnaudova-Otouzbirova Anna
Published: May 2022

Based on theoretical studies and content analysis of existing scientific literature and humane educational resources, this paper makes an attempt at defining the concept of humane education, briefly describing its historical development and emphasizing its benefits. The advantages of incorporating humane education into educational settings are discussed along with some of the challenges involved in its practical application. Furthermore, some implications are made for the inclusion of humane education in the pedagogical practice to raise the quality of education.
Digital Universities: Features and Key Characteristics
Authors:   Financial Academy, Skiba Marina , Bektemessov Maktagali ,   Abai Kazakh National Pedagogical University, Turganbayeva Alma ,   Al-Farabi Kazakh National University
Published: May 2022

The article discusses the phenomenon of “Digital Universityˮ. The goal is to identify the essence of this concept, its content, as well as the criteria for transformation into a digital university. The article outlines the problems of transformation and its ways. Digitalization, like any phenomenon, is multifaceted and can have both positive and negative effects on the educational process and the quality of education. The study conducted by the authors made it possible to describe in detail the key characteristics of a digital university, which has the features of a research organization, an educational organization, an IT company, information banks / knowledge repositories and marketing organizations.
Prevalence and determinants of postpartum depression among adolescent mothers
Authors: Rahmadhani Wulan , Kusumastuti Kusumastuti , Chamroen Pall
Published: May 2022

This study aims to determine the factor affecting the incidence of postpartum depression in adolescent mothers. The incidence of postpartum depression is quite high in Asia. The highest percentage occurred when having a first child and family history of mood disorders. The cause of this issue is varied. This study used a cross-sectional approach. The study was conducted from May 2021 to March 2022. It involved a total of 886 adolescent mothers as respondents. The instrument used the Edinburg Postnatal Depression Scale (EDPS) questionnaire. Multiple logistic regression was used to estimate the factors associated with postpartum depression. the prevalence of Postpartum depression is 50.68%. Family monthly income (95%CI: 4.09-6.75, p-value: 0.001), planned pregnancy (95%CI: 1.26-4.9, p-value: 0.000), wanted pregnancy (95%CI: 2.37-5.67, p- value: 0.001), type of delivery (95%CI: 4.39 – 5.21, p-value: 0.002), satisfied with baby's sex (95%CI: 4.39 – 5.21, p-value: <0.000), husband support (95% CI: 2.89-5.88, p-value: 0.000) were statistically significant with postpartum depression. Mothers with postpartum depression have a negative impact on themselves, their babies, and their families.
Limited incision and traditional open carpal tunnel release
Authors: Chethan L , Sunil Gaba , Atul Parashar , Modi Manish
Published: April 2022

Background: Carpal Tunnel Syndrome (CTS) is the most common compression neuropathy of the upper extremity. Even though traditional open release has been considered as standard approach for median nerve decompression, various other techniques are gaining popularity. The aim of this study was to compare the clinical and neurological outcomes between traditional open approach and limited incision approach. Methods: Twenty-eight patients with isolated CTS have included in this study of which four patients had bilateral CTS thus constituting 32 hands (19-right; 13-left). The patients were divided for treatment into two groups, Group A included 21 hands underwent limited incision release, and Group B included 11 hands released by traditional open incision. Patient's were evaluated preoperatively and in six weeks and six months postoperatively, namely, (a) clinical outcomes including Boston carpal tunnel questionnaire (BCTQ), postoperative scar tenderness, hypertrophic scar, pillar pain & quality of scar by Vancouver scar scale (VSS). (b) sensory testing using two-point discrimination (TPD) (c)motor testing using grip and pinch dynamometer, (d) neurological outcome measurement using nerve conduction study (NCS). Results: In each section of BCTQ outcomes, patients in group A showed significant improvement than in group B at both six weeks and six months follow up.
Work related stress among residents at Minia University Hospitals
Authors: Ali Al Shimaa Nagi , Abd-Elrahman Tarek Ahmed , Refaat Tahani Mahmoud , Refaie Sarah Ahmed
Published: April 2022

Background: occupational stress and its related psychological strain is a concern among resident doctors that may affect the patient care adversely. Residents face many stresses because of their high job demands and the nature of their job.  They are often subject to high workload and the pressure due to direct involvement with patients, prolonged working hours, poor job opportunity and low support. Their multiple educational and clinical roles can also affect their performance and equality of personal or professional life. The aim of the study was to evaluate occupational stress among the residents of various medical specialists at Minia university hospitals and studying the risk factors of their work related stress. Methodology: this Descriptive, cross sectional study was conducted among residents working in different departments in five main Minia University Hospitals. Data was collected using self-administered questionnaire including general health questionnaire 12 items (GHQ) and questionnaire for stress risk factors. In this study, 218 residents from a total of 243 accepted to participate in the study with response rate 89.7%, their age ranged from 24 to 29 years old (mean ± SD = 27.17 ± 1.2 years), 52.3% of them were males and 47.7% were females.
Automatic energy meter reading for multiple devices employing prepaid alerting system
Authors: Rachananjali K , Bala Krishna Bala Krishna K , Narasimha Rao C H. N.
Published: April 2022

This paper intends to establish a system which advises to keep an eye on the readings from an energy meter and regulating the switching of energy meter. The proposed system has maximum demand concept, to alert the user when the energy consumed crosses beyond the set limit in the form of text message. In this we have designed the system in such a way that if the maximum demand for the industries under load conditions exceeds the allotted demand then the Electricity Board will insist penalty for that consumer.
Characterization of Plumbagin by implying various in silico studies
Authors: Khosla Gayatri , Shukla Vikesh Kumar , Sharma Vikram
Published: May 2022

Naphthoquinone derivative was established to be an important chemical versatile scaffold belongs to Plumbago indica (Plumbaginaceae family). Its 5-hydroxy-2-methyl-1,4-naphthoquinone substituent, Plumbagin belongs to one of the diverse largest groups of plant metabolites and is obtained from the plant roots. Although the interactions of ligand receptor have not yet been confirmed, but it is found that it possess excellent antagonist properties against the multiple signaling proteins of cancer.The biggest problem like overflow of population is to be monitored to establish a balance ecologically. To resolve this problem, plumbagin is found to be a potential lead to overcome several side effects and contraindications resulted from other synthetic contraceptive analogues. The present investigation provides detailed information for understanding the various structural insights into progesterone receptors and estrogen receptors using different binding modes. It displayed excellent binding affinity against the progesteronereceptor (7.2 Kcal/mol (Ki 0.249 mM) and estrogen receptors (10.5 Kcal/mol (Ki = 0.294 mM)).
Comparison of Propranolol versus Amitriptyline as monotherapy for migraine prophylaxis
Authors: Gorukanti Deepthi Rao , Rajneesh Vallakoti , Sumalatha N , Karunakar C h
Published: May 2022

Introduction: Several drugs like Beta Blockers, SSRIs etc., are used for migraine prophylaxis. Objectives: The purpose of the present study was to compare the efficacy of propranolol and amitriptyline as monotherapy for the prophylaxis of migraine. Materials and Methods: This was a comparative, double-blinded, Prospective, randomized controlled study conducted at Department of General Medicine at Surabhi Institute of Medical Sciences. A total of 140 patients were enrolled in the study, diagnosed cases of migraine were randomly allocated using random number table to either Group 1 (Period 1: To receive tablet Propranolol 4–16 weeks and Period 2: Amitriptyline 20–32 weeks) or Group 2 (Period 1: To receive tablet Amitriptyline 4–16 weeks and Period 2: Propranolol 20–32 weeks). During the first 4 weeks, the run-in period, the patients do not receive prophylactic treatment and have to record in a headache diary the number of migraine attacks, the duration of attacks in hours and the severity.  Similarly during 16 to 20 weeks patient didn’t receive any prophylactic treatment to wear of the drug effects.
Effectiveness of training program on Individualized Communication Protocol regarding communication with comatose patient on knowledge and practice of nurses working in selected Intensive Care Unit at a tertiary care hospital
Authors: Thakur Pooja , Pugazhendi Sanchita , Prakash Kamli
Published: May 2022

Introduction: Effective communication is a keystone of the nurse patient relationship. Communicating with comatose patients is always challenging for healthcare professionals.  In order to provide quality nursing care, we need to communicate with   patients whether conscious or unconscious. This study was aimed to evaluate the effectiveness of training program on knowledge and practice of nurses working in ICUs regarding Individualized Communication Protocol with comatose patients. Methods: A quantitative pre-experimental research approach was used with one group Pre-Test- Post-Test-only Design. Total enumeration sampling technique was used to select 171 Staff Nurses from the selected ICUs. A structured questionnaire containing knowledge and skill items were used to assess knowledge and practice related to communication. Result revealed that there was significant improvement in knowledge post test score (20.09±3.21) after intervention as compared to pretest scores (13.23±2.96 with p-value of 0.0001. Data also represented significant improvement in practice posttest score (30.96±4.46) as compared to pretest score (6.75±1.57) with p-value of 0.0001. Discussion: Study revealed that teaching programme was effective in improving nurse’s knowledge and practice regarding Individualized Communication Protocol. Results strongly recommend for regular training sessions for health care professionals which help them to improve communication by enabling them to enhance their practice.
Design, synthesis and biological activity of 4-amino-5-(Benzimidazole-1-yl) triazole
Authors: Honmane P. P. , Singh S. K. , Mohite S. K.
Published: May 2022

Triazoles are an important class of nitrogen containing heterocycles, because many of them exhibit interesting biological activities, such as anti-inflammatory, antidepressant, antifungal, anticancer,anti-TB, analgesic and hypoglycemic. Sulfur-linked 1,2,4-triazoles represent an important group in lead compound discovery. Many bioactive sulfur-linked 1,2,4-triazole have been reported, such as antibacterial activity, antitumor activity, anti-HIV activity, anti-TMV (tobacco mosaic virus) activity, and so on. We report Synthesis and Biological activity of 4-amino-5-(Benzimidazole-1-yl) Triazole.
RNN model-based classification of wireless capsule endoscopy bleeding images
Authors: Mohankumar C. E. , Kumar S. V. Dharani , Senthilkumar S , Sornagopal V , Maharajan M S
Published: May 2022

WCE (wireless capsule endoscopy) is a technique that may be used to diagnose gastrointestinal issues and provide painless gut imaging. Regardless, a variety of variables, such as effectiveness, tolerance, safety, and performance, make widespread use and modification challenging. Furthermore, automated analysis of the WCE data is essential for detecting anomalies. When a patient's digestive system is imaged using WCE, a vast amount of data is generated and these challenges have been addressed using a variety of computer assisted and vision-based technologies, but they do not achieve the essential level of precision, and further work is required. With this work, the goal is to create a system that can automatically analyze WCE images to identify problems and assist practitioners in making right diagnoses. Finally, a comparison of SODM-S1 with SODM shows that by modifying features to increase spatial dependency, our suggested technique may really improve model performance.
FG comparative study between antigen-antibody complex vaccine and traditional vaccine of infectious bursal disease in commercial broiler
Authors: Abdulhadi Mohammed Lateef , Jaafer Nawal S.
Published: April 2022

Infectious bursal disease (IBD) is a viral disease causes increased mortality and severe immunosuppressionin commercial chickens. The virus infects the bursa of Fabricius of particularly the actively dividing and differentiating lymphocytes of the B-cellslineage of young chickens, resultant in morbidity, mortality, and immunosuppression. Immunosuppression enhances the susceptibility of chickens to other infections and interferes with vaccination against other diseases. Immunization is the most important measure to control IBD; however, wild usage of live vaccines has resulted in the evolution of new strains. Although the immunosuppression caused by IBDV is more directed toward the B lymphocytes, the protective immunity in birds depends on inducement of both humeral and cell-mediated immune responses. Currently vaccination mainly used to control IBD. In this study, Group 1(n = 50) received the immune complex vaccine (Bursa-Plex®) s/c at 1 day of age. Group 2 (n = 50) received the GUMBORO (D78)(intervet)vaccine by drinking water and Group 3 (n = 50) were non IBD vaccinated birds. The aim of study: Evaluation between two types of IBD vaccines, immune-complex IBD vaccine (Bursaplex®) with the use of GUMBORO D78(intervet) vaccine. Depending on:At 7,14,21, 28th day P.V. • Serology (IBD ELISA (INFY)- cellular immunity).
Surface properties and elemental composition of human treated dentin matrix nano-scaffold as direct pulp capping material
Authors: Saeed Mahmoud A. , Alfotoh Mona M. Abo , Mubarak Rabab T. , Grawish Mohammed E.
Published: April 2022

Objective The aim of the study was investigating surface topography, roughness, and wettability of the TDM semi-rigid nano-scaffold. In addition to its chemical composition to prove the principle of using as direct pulp capping (DPC) material. Materials and methods: Forty sound and fully erupted premolars scheduled to be extracted for orthodontic treatment were involved for the TDM scaffolds preparation. The surface and chemical properties were investigated in comparison with UTD. The surface topography was investigated using SEM while AFM was used for studying SR. Surface wettability was analyzed via sessile-drop goniometry protocol. However, the elemental composition was analyzed using EDX. Result: The surface characterization of the TDM scaffolds revealed a nano-tubular pattern with high surface wettability. However, the elemental analysis revealed its optimum partial demineralization. Conclusion: the surface and elemental composition of TDM semi-rigid scaffold are promising to be a reasonable DPC material.
Power of probiotics in periodontal disease
Authors: Goswami Pallavi , Saini Ashish , Kashyap Akanksha , Rajput Ankur , Baig Aasim H , Pant Vandana A
Published: April 2022

Probiotics, or health-beneficial microbes, have been around since the early twentieth century. In recent years, it has piqued the curiosity of researchers. The therapeutic paradigm has shifted from particular bacterial eradication to probiotics modifying bacterial ecology. Probiotics may be a viable field of investigation in periodontal care, especially with the rise in antibiotic resistance. Probiotics have considerable data to support their role in dental caries; however there is less evidence for their impact in periodontal disease. Thus, simply adding probiotic items to one's diet can halt, slow, or even dramatically delay the progression of periodontal illnesses, supporting a healthy lifestyle to combat periodontal infections. As their position in periodontics is still in its infancy, several issues have been raised about the benefits of probiotic supplementation. To assess their long-term repercussions for oral health and disease, a thorough understanding of the extensive ecological changes they cause in the mouth is required. The evidence for using probiotics to maintain oral health and prevent periodontal disease is reviewed in this research.
Correlation between periodontal pocket depth and red complex bacteria among tobacco user
Authors: Charokar Aarti , Gupta Abhishek , Singh Vikram , Sharma Sakshi , Rajput Ankur Singh , Goswami Pallavi
Published: April 2022

Aims- The present study is to evaluate the presence of red complex microorganism and relation with the prevalence of anaerobic bacteria and corelation with pocket depth in Periodontitis among tobacco user. Materials and Methods- The BANA (N-benzoyl-DL-arginine-naphthylamide) test was used to analyze subgingival microbiota. 400 subject age between 20-55 enrolled in this study, subject divided into three groups Tobacco Chewers, Tobacco Smokers, Both chewers and smokers and Non tobacco user. Result – The present study compared the subject with BANA test and pocket depth, the study shows tobacco smokers had deep pocket in comparison to other subject, which concluded that tobacco smokers show greater destruction of periodontium. Conclusion- Tobacco is harmful substance either it is used in any form (Chewing and Smoking), but study clearly indicate tobacco smoking are responsible for more destruction of Periodontium. The tobacco cessation programme should be implemented to prevent periodontitis and smoking prevention should be done by health education.
Effect of Pranayama on premenstrual syndrome in the present scenario
Authors: Banwal Shephali , Siddiqui Zulfiqar Ullah
Published: April 2022

The present investigation is aimed to conduct a comparative study that examine the effect of pranayama on premenstrual syndrome to gain insight on the role of pranayama. Total 100 females age range from 10 to 50 years participated in this study from Kapurthala, district of Punjab, India. Further the population was divided into two groups with equal number of participants (n=50), group A (no intervention) and group B (pranayama). The subjects of group A did not perform any type of breathing and yogic technique for past four to five months and group B used to perform pranayama exercise on regular basis. Results showed positive significant effect of pranayama practices on premenstrual syndrome (t=58.26, p<.01).
Knowledge, attitude, and practice of pharmacists towards adverse drugs reaction in west Khasi Hills
Authors: Lyngkhoi Angelina , Singh Pallavi , Khongthaw Jasmine L.
Published: May 2022

The purpose of the study is to identify assess and evaluate the adverse drug reactions experienced by the patients from the clinic, and to monitor the adverse drug reactions by spontaneous reporting. As we all know, an adverse drug reaction is an adverse event with a causal link to a drug and can lead to causes of morbidity and mortality. Clinical pharmacists can play an essential role in detecting and preventing as well as management of adverse drug reactions. In general, the patient satisfaction and attitude in West Khasi Hills are the sole subjects of the study as many of the villagers are not able to visit the clinics in town areas in which they depend mostly on the clinical pharmacies for their health care. The entire study was a plan to carry out for a period of months from November (2020) to April (2021). The study was conducted in a cross-sectional method study design. There are about 138 willing participants in the study, most of the pharmacists in West Khasi Hills have low (89.8%) Knowledge about Pharmacovigilance and adverse drug reaction reporting, it was found that about 79.6% of responders had experienced adverse drug reactions in their practice.
Synthesis, characterization and evaluation of the bacterial, antioxidant and anticancer activity of pyrimidine derivatives
Authors: Hamid Ibtihal Kamel , Attia Khaled Abdel Aziz
Published: May 2022

In this paper, heterocyclic hexagonal rings were prepared for pyrimidine derivatives [I9-I16] by reacting a mole of gluconate derivatives with a mole of cyanoguanidine and using ethanol as a solvent. The accuracy of the compositions of the prepared compounds was confirmed by measuring the physical properties, including melting point, color, and molecular weight, as well as through spectroscopic measurements, including the infrared spectrum, the proton nuclear magnetic resonance spectrum, and the carbon-13 nuclear resonance spectrum. The biological activity of some prepared compounds and on two types of pathogenic bacteria, one of which is Gram-positive, which is Staphylococcus aureus, and one of which is Gram-negative, which is Escherichia coli, was studied. And the culture medium of the Multer Hinton Agar type was used, and chemical solutions were prepared for the two compounds (I9, I16) with concentrations (0,01, 0.001, 0.0001) mg /ml using a solvent dimethyl sulfoxide (DMSO). The sensitivity test of bacterial isolates used in the study was carried out by diffusion method, and the antibiotic Ciprofloxacin was used as a control sample. The effect of compound I15 on the removal of free radicals was also studied using DPPH root and at different concentrations.
Rare case of neonate with meconium peritonitis
Authors: Jain Apoorv , Lakhkar Bhavana , Taksande Amar , Meshram R. J. , Ramakrishnan Lavanya , Myadam Sushma , Desai Kushal
Published: May 2022

It's unusual to find a meconium cyst in a premature newborn. Meconium pseudo cyst is a consequence of meconium peritonitis, a sterile chemical peritonitis caused by a perforation of the uterine tract. When a puncture in the intestine does not heal and communication with the cyst continues after birth, the cyst can expand, the cyst can get infected, and the pseudo cyst can rupture. This is a case report of a newborn who developed perforated peritonitis due to the rupture of a meconium pseudo cyst [1]. Our patient was born prematurely at 34 weeks and had a caesarean procedure. She had a large abdominal distention that was later confirmed as a meconium cyst.
STABILITY INDICATING RP-HPLC METHOD DEVELOPMENT AND VALIDATION OF MEROPENEM AND VABORBACTAM IN PHARMACEUTICAL DOSAGE FORM
Authors: T. Prasanthi , Rao A. Lakshmana , Rao B Mohana ,   Department of Pharmaceutical Analysis, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru - 521 356, A.P., India
Published: May 2022

A simple, novel, rapid, accurate and precise stability indicating RP-HPLC method was developed and validated for simultaneous estimation of meropenem and vaborbactum in pharmaceutical dosage form. Meropenem an antibacterial, and vaborbactam, a beta-lactamase inhibitor are indicated for the treatment of complicated urinary tract infections including pyelonephritis caused by designated susceptible bacteria. The drugs in this combination were determined by using o-Phosphoric acid (OPA) buffer: acetonitrile (50:50 V/V) as a solvent. Meropenem and vaborbactum peaks were detected at 2.334 and 3.542 min, respectively. The flow rate was 1 mL min-1 and the effluent was monitored at 260 nm. The developed method was validated for different parameters according to ICH guidelines. Linearity range was adjusted to 25-150 μg mL-1 for both drugs. % RSD values for precision studies were found to be within the limits. The % mean recovery was found to be 98.93 for meropenem and 99.94 for vaborbactum. Degradation studies were conducted and the method separates the drug from its degradation products, hence it can be used as stability indicating method for estimation of both drugs in combined dosage form.
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF A NOVEL HPTLC (METHOD) FOR THE SIMULTANEOUS ESTIMATION OF BERBERINE, GALLIC ACID, QUERCETIN AND PIPERINE IN A POLYHERBAL FORMULATION
Authors:   Department of Quality Assurance, Oriental College of Pharmacy, Plot No. 3,4,5 Sector No. 2, Near Sanpada Railway Station, Sanpada (W), Navi Mumbai – 400 705, Maharashtra, India, Vaidya Shivani A. , Kshirsagar Rishikesh R. , Laddha Kirti S. , Jain Vandana N.
Published: May 2022

A novel, accurate, precise High Performance Thin Layer Chromatography (HPTLC) method for the simultaneous estimation of berberine, gallic acid, quercetin and piperine in a polyherbal formulation has been developed and validated as per ICH guidelines. A good chromatographic separation was achieved using mobile phase consisting of toluene, ethyl acetate, methanol and formic acid in the ratio of 6: 6: 2: 1 (V/V/V/V) with a wavelength of 254 nm using UV-Visible (UV-Vis) detector. The retention factors of berberine, gallic acid, quercetin and piperine were found to be 0.37, 0.51, 0.72 and 0.86, respectively. The calibration graph was found to be linear within the tested range of 1-10 µg band-1 for all the selected phytoconstituents with a correlation coefficient > 0.99. The high recovery values (98-102 %) indicate satisfactory accuracy. The % RSD values were found to be less than 2 % in the precision study, which reveals that the method is precise.
LEAD PHYTOMOLECULES FOR HEPATOPROTECTIVE DRUG DEVELOPMENT
Authors:   Department of Pharmacology, Faculty of Pharmacy, R.B.S. Engineering Technical Campus, Bichpuri, Agra-283 105, U. P., India, Agrawal Krishn K. , Murti Yogesh
Published: May 2022

Plants are the precious gift of nature to mankind and play a major role in the treatment of various diseased conditions from the ancient times. Functional bioactive compounds of plant origin have been an invaluable source for many human therapeutic drugs and have played a major role in the treatment of diseases around the world. Natural products or their derivatives have led to many existing drugs, offering a chemically diverse space for discovery of hepatoprotective compounds. In order to represent the studies on chemical diversity of phytomolecules with hepatoprotective activity, this review is complied. This review captures a number of isolated phytomolecules having hepatoprotective potential. Phytomolecules as lead compounds for new drug discovery will boost up the researchers to work on it and find effective molecules for the treatment of liver injuries.
Study of Effect Changing the Blade Shape and Lift Angles on Horizontal Wind Turbine
Authors: Astanto Ichsan , Arifin Fatahul , Bow Yohandri , Sirajuddin
Published: April 2022

The lack of energy commodities such as coal and petroleum makes the cost of these commodities soar. This event shows how much countries in the world are still very dependent on fossil fuels, and it is fitting that the transition to new renewable energy can be realized soon, low emission and environmentally friendly energy is the hope in the future. Indonesia has a supply of renewable energy sources that are abundant is a great force for this clean energy revolution. The momentum of the presence of the first wind farm in Indonesia operating in Mattirotasi Village, Sidrap Regency, Central Sulawesi in Indonesia with a wind power plant capacity (PLTB) of 75 MW is positive evidence that the government is starting to pay more attention to the development of renewable energy technology in Indonesia. Turbine technology that is able to optimize wind speed in Indonesia must be the answer so that this energy is more useful.  In this study, the idea for an experimental analysis of "Study of the Effect of Blade Shape Change and Lift Angle on Horizontal Wind Tubin using Nvis 6009 Experimentation with Solar and Wind Energy props. The Nvis 6009 is a prop used by vocational schools to understand the concept of a DC power plant based on solar and wind energy. To optimize low wind speed, on Nvis 6009 horizontal axis wind turbine (HAWT) with different type 3 Blade and changes in lift angle, so that we can know the effect of the resulting voltage change, so that we can know the effect of the resulting voltage change. Simple illustrations using the Solidworks application are done as validation of the results of previous research and to obtain preliminary data of research experiments. The final results of the test on Type Blade II obtained maximum data at a Blade angle of 13 ° with a wind speed of 3.9 m / s, Blade Rotation 2587 Rpm produces a voltage of 2.8 V.
The Application of Vacuum Valve Technology as AFR Settings in 3500 Watt Electric Generator Operated by Methane Gas
Authors: Widagdo Tri , Martomi Eka Satria , Sundari Ella , Yuliati Selastia
Published: April 2022

The scarcity of fuel oil, especially the gasoline type, is now a national problem that needs to be solved. This is caused by the rapid growth of industry and transportation. On the other hand, the problem of handling wet garbage has not been maximal, causing pollution that can disrupt health. The impact of this problem is felt also in the use of household-scale generators that operate using gasoline fuel. This study aims to convert gasoline to methane gas in the operation of a 3500 Watt Generator (Electric Generator Set). Methane gas (CH4) is obtained from the gasification process of wet waste. The method used for the AFR (Air-Fuel Ratio) regulator is the use of vacuum valve components. The use of this method cannot be separated from the easy aspects of the maintenance/repair, easy to make and cheap price. The target to be achieved in this research is to get performance data of generators operated with Methane gas fuel. The generator which is used as a research object is a generator household scale with a maximum power of 3500 Watt. Results variables to be observed among other: engine efficiency as well as optimum engine AFR generator. Furthermore, the data is compared with the data generated generator that uses gasoline fuel. This research is an experimental study, starting with the design of the vacuum valve component, followed by the installation of the component on the generator machine and ending with a machine test. The experimental data on the generator with the nominal power of 3500 Watt is: Operated by Gasoline, the optimum power, Popt is 3750 Watt, Max. efficiency, ηmax is 62.2%; AFRopt is 6.7, then operated by methane gas, optimum. power, Popt is 3270 Watt, Max efficiency, ηmax is 66,1%, AFRopt is 7,2. So, gas methane can be used to replace gasoline to operate 3500 Watt generator.
Tolerancia al estrés por sal y cadmio en cuatro genotipos de Medicago sativa L
Authors: Pacheco Insausti María Cecilia , Zapico Martín G. , González Evelyn A. , Fernández Eliana , Gutiérrez Mariano H. , Stege Patricia W. , Pedranzani Hilda E.
Published: May 2022

Objetivo: Evaluar la tolerancia de cuatro genotipos de Medicago sativa L. a la salinidad y cadmio, mediante el estudio de la geminación, parámetros de crecimiento, pigmentos fotosintéticos y respuesta osmocompatible. Materiales y métodos: El diseño experimental fue completamente al azar con arreglo factorial: tipo de genotipo: CW 197, Trinidad 87, CW 660 y Salina PV y niveles de estrés salino (NaCl) y cadmio (Cl2Cd) estrés. Se realizó ANOVA factorial para identificar la influencia de las condiciones de estrés en las variables medidas, se realizaron análisis de comparaciones múltiples de medias cuando se encontró un efecto significativo. Se sembraron 20 semillas por triplicado regadas con agua (control) y soluciones entre 10 a 200 mM de NaCl y 100 a 500 µM de Cl2Cd para el estudio de germinación. En plántulas de cuatro semanas crecidas en terrinas regadas con solución nutritiva (control) y concentraciones crecientes de NaCl (50-200 mM) y Cl2Cd (25µM-100 µM) se midieron crecimiento, prolina y pigmentos fotosintéticos. Resultados: Bajo salinidad, los genotipos CW179 y CW660 fueron tolerantes a la salinidad en la germinación, y los genotipos Salina PV y Trinidad 87 fueron más tolerantes durante el crecimiento. En respuesta a Cd, los genotipos mostraron tolerancia durante el crecimiento. La prolina fue osmoprotectora frente a la salinidad, pero no contra el estrés por Cd. Los pigmentos fotosintéticos disminuyeron con el estrés salino; sin embargo, Cd no los afectó. Conclusión: El genotipo CW 660 fue el más tolerante a la salinidad y al Cd durante la germinación. Se concluye que los genotipos Trinidad 87 y Salina PV son tolerantes a la sal y los genotipos CW 197 y CW 660 son sensibles, durante el crecimiento. Bajo estrés por Cd, todos los genotipos mostraron tolerancia durante el crecimiento. La prolina y los pigmentos fotosintéticos fueron indicadores de tolerancia al estrés salino.
Influence of interplanted species on N and P resorption efficiency of companion species in mixed plantations of various species combinations raised on mine spoil
Authors: Singh Arvind
Published: April 2022

Influence of interplanted species on N and P resorption efficiencies of companion species was studied in mixed plantations of various species combinations raised for revegetation of coal mine spoil. The species combinations were legume: legume, legume: non-legume and non-legume: non-legume. The interplanted species were found to alter the N and P resorption efficiences of companion species in all combinations. In leguminous species the N and P resorption efficiencies dropped with increase in foliar N and P concentration, whereas in non-leguminous species the N and P resorption efficiencies increased with increase in foliar N and P concentration. Across all species, the N resorption was found independent of foliar N status, while the P resorption efficiency increased with increase in foliar P concentration.
Распознавание взаимодействия объектов в режиме реального времени
Authors: Nuralin M.D. , Daineko Y.A.
Published: May 2022

The article presents the development and research of recognition of the interaction of the human hand with objects. The developed model receives frames from an RGB camera and is performed in three stages: (a) hand tracking, (b) object tracking, and (c) action recognition. The steering wheel is used as the object under study.

В статье представлена разработка и исследование распознавания взаимодействия человеческой руки с объектами. Разработанная модель получает кадры от RGB камеры и выполняется в три этапа: (а) отслеживание руки, (б) трекинг объекта, и (с) распознавание действия (action recognition). В качестве исследуемого объекта используется рулевое колесо.