bluuebunny/crossref_metadata_2025 huggingface dataset:
Realization of extreme nonstoichiometry in gadolinium aluminate garnet phosphors by nonequilibrium synthesis
Authors: Fang Xue , Castaing Victor , Becerro Ana , Cao Weiwei , Veron Emmanuel , Zanghi Didier , Dyer Matthew , Genevois Cécile , Allix Mathieu , Pitcher Michael
Published: February 2024

Rare-earth aluminates with the cubic garnet structure are an important class of optical materials with a range of technological applications. When synthesized as ceramics or single crystals, these materials do not tolerate large deviations from ideal RE3Al5O12 stoichiometry, and their luminescence properties are typically controlled by dopant selection. Here, we use glass crystallization as a nonequilibrium synthesis route to a new family of highly nonstoichiometric gadolinium aluminate garnet (GAG) phosphor hosts Gd3+xAl5-xO12 with 0 ≤ x ≤ 0.60. In these materials, excess Gd3+ is accommodated on the octahedrally-coordinated Al3+ sublattice of the garnet structure. The most extreme composition Gd3.6Al4.4O12 has 30% of these Al3+ sites substituted by Gd3+, but retains the cubic garnet structure type despite the vast size contrast between the two cations. The accessible nonstoichiometry range for GAG extends far beyond that of nonstoichiometric YAGs (Y3+xAl5-xO12, 0 ≤ x ≤ 0.4), enabled by a broader glass-forming domain in the Gd2O3 – Al2O3 system. We investigate three model phosphor systems based on nonstoichiometric GAG, and determine the crystallographic distributions of the dopant ions where possible, to evaluate the response of upconversion and photoluminescence to extreme nonstoichiometry. In particular, upconversion from the small rare-earth activator Tm3+ is found to be sensitive to nonstoichiometry in GAG. These results demonstrate that highly nonstoichiometric garnet aluminates are not limited to small rare-earth hosts such as YAG and should be realizable across the full 4f series, highlighting the potential for color tuning of new upconversion phosphors by control of host stoichiometry and opening new opportunities for development of different garnet-based optical and magnetic materials.
Aquamarine: Quantum-Mechanical Exploration of Conformers and Solvent Effects in Large Drug-like Molecules
Authors: Medrano Sandonas Leonardo Rafael , Van Rompaey Dries , Fallani Alessio , Hilfiker Mathias , Hahn David , Perez-Benito Laura , Verhoeven Jonas , Tresadern Gary , Kurt Wegner Joerg , Ceulemans Hugo , Tkatchenko Alexandre
Published: February 2024

We here introduce the Aquamarine (AQM) dataset, an extensive quantum-mechanical (QM) dataset that contains the structural and electronic information of 59,783 low-and high-energy conformers of 1,653 molecules with a total number of atoms ranging from 2 to 92 (mean:50.9), and containing up to 54 (mean:28.2) non-hydrogen atoms. To gain insights into the solvent effects as well as collective dispersion interactions for drug-like molecules, we have performed QM calculations supplemented with a treatment of many-body dispersion (MBD) interactions of structures and properties in the gas phase and implicit water. Thus, AQM contains over 40 global (molecular) and local (atom-in-a-molecule) physicochemical properties (including ground-state and response properties) per conformer computed at the tightly converged PBE0+MBD level of theory for gas-phase molecules, whereas PBE0+MBD with the modified Poisson-Boltzmann (MPB) model of water was used for solvated molecules. By addressing both molecule-solvent and dispersion interactions, AQM dataset can serve as a challenging benchmark for state-of-the-art machine learning methods for property modeling and \textit{de novo} generation of large (solvated) molecules with pharmaceutical and biological relevance.
Analysis of kinetic asymmetry in a multi-cycle chemical reaction network establishes the principles for autonomous compartmentalized molecular ratchets
Authors: Penocchio Emanuele , Bachir Ahmad , Credi Alberto , Astumian R. Dean , Ragazzon Giulio
Published: February 2024

Kinetic asymmetry is a key parameter describing non-equilibrium chemical systems: it indicates the directionality of a chemical reaction network under steady-state, non-equilibrium conditions. So far, kinetic asymmetry has been evaluated only in networks featuring a single cycle. Here, we have investigated kinetic asymmetry in a multi-cycle system using a combined theoretical and numerical approach. Inspired by the latest experimental developments, we selected a com-partmentalized redox-controlled network as a model system. We report the general analytical expression of kinetic asymmetry for multi-cycle networks, and specify it for the present system, which allows anticipating how key parameters influence directionality. We establish that compartmentalization can enable autonomous energy ratchet mechanisms, with directionality dictated by the system's thermodynamics. Kinetic simulations confirm analytical findings and illustrate the interplay between diffusion, chemical, and electrochemical processes. The presented treatment is general, as the same procedure can be used to assess kinetic asymmetry in other multi-cycle networks, facilitating the realization of en-dergonic processes across domains.
Rapid and complete prediction of Madder natural dyes’ color and properties through computational method
Authors: TRAN Linh , BERRAUD-PACHE Romain , JABER Maguy
Published: February 2024

Experimental chemists traditionally hold experimentation in high regard, but computational chemistry has the potential to revolutionize this perspective. Our work exemplifies this shift, employing computational methods such as Density Functional Theory (DFT), Time-Dependent Density Functional Theory (TD-DFT), and Quantum Mechanic/Molecular Mechanic (QM/MM) to delve into the realm of photodegradation of color. Focused on Madder dye, a natural and historical pigment renowned for its diverse color properties, we tackle challenges that traditional experimentation struggled to address. The historical difficulty in deciphering the spectroscopic properties of Madder's colorants due to extraction challenges, impurities, and high costs is overcome through computational spectroscopy techniques. By marrying computational insights with experimental data, we predict UV-Vis, color, and NMR spectra, considering factors like pH, solvent effects, and conformers. The study underscores the impact of solute-solvent interactions on reproducing experimental measurements, laying the foundation for a comprehensive database to understand color properties in cultural heritage. These initial findings pave the way for future exploration of complex systems like Madder lake. This transformative shift empowers researchers and scientists to conquer crucial challenges in comprehending the properties of ancient colors for cultural heritage preservation, advancing the development of durable bio-sourced colors, and discovering new color applications.
Evaluation of follow-up strategies for women with epithelial ovarian cancer following completion of primary treatment [Russian translation of the Plain Language Summary (PLS) of the Cochrane Systematic Review]
Authors: Yudina Ekaterina V.
Published: February 2024

This publication is the Russian translation of the Plain Language Summary (PLS) of the Cochrane Systematic Review: Zachou G, El-Khouly F, Dilley J. Evaluation of follow-up strategies for women with epithelial ovarian cancer following completion of primary treatment. Cochrane Database Syst Rev. 2023;8(8):CD006119. DOI: 10.1002/14651858.CD006119.pub4
Development and Validation of HPLC Method for Simultaneous Estimation of Etodolac andThiocolchicoside in Bulk and Pharmaceutical Dosage Form
Authors: Mathews Baiju , Vivek Bharatbhai Patel , B Kumar Pramod , Aiswarya G , Tom Cyril
Published: February 2024

Etodolac ETD and Thiocolchicoside THC combination is used in the treatment of musculoskeletal pain. Literature review shows RP-HPLC method with buffered mobile phase.1The objective of the work is to develop simple precise accurate specific and robust analytical method for simultaneous estimation of Etodolac and Thiocolchicoside in bulk and pharmaceutical dosage form.The present work describes a validated high performance liquid chromatographic method for simultaneous estimation of Etodolac and Thiocolchicoside in bulk and pharmaceutical dosage form. Chromatography was performed on Hypersil BDSC18 column 250 mm x 4.6 mm 5 mum particle size column with mobile phase containing Methanol Water Acetic acid in the ratio of 70 30 0.1 vvv. The flow rate was 1.0 mLmin and eluent monitored at 260 nm.
Design and Evaluation of Tramadol HCl Sustained Release Matrix Tablets
Authors: Archana T , Kundavaram Raju , Gayathri Devi M
Published: February 2024

The objective of present study was to designand evaluate Tramadol HCl sustained release matrix tablets. Tramadol is an opioid agonist commonly prescribed for the treatment of acute or chronic pain. Tramadol has a moderate half-life of six hours. Patients have to take multiple doses throughout the day to maintain the effect which results in dependence and addiction. So an attempt is made to develop a sustained release matrix tablets to achieve therapeutically effective concentrations of drug in systemic circulation over an extended period of time thereby the dosing frequency can be reduced. Formulation contains tramadol hydrochloride MCC HPMC K100M xanthan gum PVP K-30 isopropyl alcohol magnesium stearate and talc. Various formulations were developed using different concentrations of rate releasing polymer Xanthan gum and HPMC K100M for extending the drug release up to 10 h. The study involved preparation of granules by wet granulation technique followed by pre compression evaluation and tablet punching using a compression machine followed by post compression evaluation and only the one which met standards was selected and analyzed for drug content using UV- Visible spectrophotometer. From the results it was found that as the polymer concentration was increased the rate of drug release was retarded.
Pharmacognostic Evaluation and HPTLC Analysis of Multiple Phytoconstituents in Anoral Antidiabetic Polyherbal Ayurvedic Formulation
Authors: Teeka Sathiesh Roopashree , Kumar Ramakrishnappa Anil , Kumar Kewal Chand Rakesh , Narayana Prashanth
Published: February 2024

In present scenario providing scientific evidences using modern analytical instruments and techniques is one of the most essential criteria for establishing identity purity safety and efficacy. In other words ldquoStandardizationrdquo especially with regard to polyherbal formulations comprising more than one crude drug is undoubtedly a challenging task but is need of the hour. Here we attempt to establish a set of quality control parameters for an Ayurvedic polyherbal formulation comprising twelve herbal ingredients used for management of Diabetes. Apart from establishing proximate values HPTLC technique was first time developed for simultaneous identification of phytoconstituents i.e. Curcumin Emodin Gallic acid Ellagic acid and Ascorbic acids in the formulation. Proximate values were well within the acceptable limits. This is one of its kinds as we have developed a HPTLC technique for simultaneous identification of five chief phytoconstituents in the polyherbal formulation.
Ameliorative Effect of Allantoin, Beta cyclodextrin and Combination of Both against Diabetic Cognitive Impairment
Authors: Semol Mohammed , Razdan Rema , Minaz Nathani , Upadhye Dhanashree
Published: February 2024

Cognitive impairment is one of the major and least identified complication of diabetes mellitus. The objective of our study was to evaluate the protective effect of allantoin beta cyclodextrin and combination of both in diabetic cognitive impairment. Diabetes was induced by single intraperitoneal administration of streptozotocin STZ 53 mgkg body weight. After 8 weeks of treatment spatial memory percentage of glycosylated haemoglobin and the levels of neurotransmitters in the cerebellum part of brain were measured. In addition to this hippocampal acetylcholinesterase activity antioxidant enzymes and MDA levels were also assessed. Our results exhibit that treatment with allantoin beta cyclodextrin and combination of both improved spatial memory decreased glycosylated haemoglobin and increased neurotransmitters levels. Further the treatment decreased acetylcholinesterase activity and lipid peroxidation and increased the antioxidant enzymes. Thus we conclude that allantoin beta cyclodextrin and combination of both ameliorates the diabetes induced cognitive impairment in rats.
Validation of RP-HPLC Method and UV Spectrophotometric Method for the Quantitative Determination of Aztreonam in Bulk and Pharmaceutical Dosage Form
Authors: Bhattacharyya Sayani , Sudheer and Bharani S Sogali Preethi
Published: February 2024

The present study focuses on the development of rapid and sensitive development of RP- HPLC method with UV detection and spectrophotometric method for routine analysis of aztreonam in bulk and pharmaceutical dosage form. Chromatographic method was developed in C-8 Phenomenex HPLC column with a mobile phase methanol phosphate buffer pH 5.4 7030 at a flow rate of 1mlmin at 300 nm. The assay showed linearity in the range of 2-10 microgml with a correlation coefficient of 0.9999. The UV spectrophotometric method was performed at 293 nm in phosphate buffer solution of pH 7.4. The correlation coefficient was found to be 0.9989. Both the processes were found to be sensitive rapid precise accurate and robust. Therefore it can be concluded that both the processes can be used for routine quality control test of aztreonam in bulk and pharmaceutical preparation.
Evaluation of Cardio Protective Activity of Musa Acuminata in Ischemia-Reperfusion Induced Myocardial Infarction in Rats
Authors: Raj Sharma Uday , Raju Ramesh , Vada Surendra , Taj Nageena , Kochunni Sankar Binai , Raj Joshi Abhishek , Panduranga Mudagal Manjunath
Published: February 2024

Heart diseases are the major causes for most of the mortalities in developed and developing countries. Reperfusion damage once in a while called ischemia-reperfusion damage IRI or re-oxygenation damage is the tissue harm caused when blood supply comes back to tissue re- perfusion after a period of ischemia or lack of oxygen anoxia or hypoxia so the cardioprotective of the extract of Musa acuminata L. extract in ischemiandashreperfusion-induced myocardial infarction in rats are evaluated by measuring the infarct size of the heart and evaluating the serum cardiac markers like Aspartate Aminotransferase ASTGOT Alanine Aminotransferase ALTGPT creatinine kinase CK and lactate dehydrogenase LDH. The in vivo cardiac parameters are also taken care because the increase in the anti-oxidant in the body indicates the reduction of the oxidative cell damage. The ethanolic extract of Musa acuminata L. peel showed a significant cardioprotective effect against ischemia reperfusioninduced myocardial infarction in rats.
Essence of Chronopharmacology in Allopathy
Authors: Mahurkar Dr.Nitin
Published: February 2024

none
From chief editor’s desk…
Authors: Mahurkar Dr.Nitin
Published: February 2024

none
Formation of Paliperidone Cocrystals as Multi-Component Systems for the Functionality Enhancement
Authors: Raheem Thayyil Abdul , Thimmasetty Juturu , Nayak N Shashank , Ghosh Tanmoy , S Kamath K Shwetha , S Naveen K
Published: February 2024

The aim of the present investigation was to prepare paliperidone-PHBA PAL-PHBA paliperidone-saccharin sodium PAL-SS cocrystals for improved physico-mechanical properties. The paliperidone cocrystals prepared by solvent evaporation technique were fully characterized by employing melting point aqueous solubility dissolution Fourier Transform Infrared spectroscopy FTIR Differential Scanning CalorimetryDSC Powder X-Ray Diffraction PXRD and Scanning Electron Microscopy SEM techniques.Six formulations of orodispersible tablets of selected paliperidone cocrystals were prepared using Croscarmellose Sodium CCS Sodium Starch Glycolate SSG and Crospovidone CP as superdisintegrants. The prepared batches were evaluated for hardness friability weight uniformity content uniformity in vitro dispersion timeandin vitro drug release.Based on the results formation of cocrystals was confirmed. Pharmaceutical behaviors in terms of solubility dissolution and tabletability suggested superior functionality of cocrystals. The formulations F-III and F-VI containing CP were identified as better formulations among the formulations developed by PAL-SS and PAL-PHBA cocrystals respectively. Further it could be reasonably expected that the obtained formulationmayresult in an increase in its bioavailability with the possibility of reducing drug dosage and side effects.The concept of cocrystallizationwas successfulfor preparing paliperidone cocrystals with improved physico-mechanical properties.
Indicadores para avaliar a assistência farmacêutica municipal
Authors: Silva Gomes Ilvia , Rocha Farias Mareni , Nair Leite Silvana , Raijche Mattozo Rover Marina
Published: February 2024

Esse manuscrito descreve as etapas de adaptação e validação de indicadores para avaliação da Assistência Farmacêutica municipal na região amazônica. Considerar o contexto dos municípios em avaliações indica o reconhecimento de suas particularidades aumentando a consistência e legitimidade da avaliação. Os indicadores passaram validação de conteúdo em duas etapas: consulta aos especialistas e oficina de consenso. Participaram representantes de dois municípios do estado do Pará, da 9°Regional de Saúde do Estado, instituições formadoras da região e pesquisadores da área. Foram feitas adaptações quanto ao contexto, atualização da legislação e síntese de alguns pontos para aumentar a clareza das análises. Destaca-se a inclusão das unidades de saúde ribeirinhas e fluviais no objeto de estudo; nos indicadores logísticos, a verificação de adequações na programação e aquisição de medicamentos considerando as distâncias e estações sazonais, e diferenças na distribuição entre as unidades de áreas urbanas, rurais e ribeirinhas. Além disso, incluiu um indicador que avalia a existência de ações de saúde relacionadas às práticas tradicionais da população. As discussões na oficina pautaram a importância de contemplar o impacto do fator amazônico na logística e acessibilidade da Assistência Farmacêutica. Este processo e permite análises adequadas para subsidiar o planejamento de ações visando superar as fragilidades da região.
Política Pública de saúde
Authors: De Souza Neto Bezamat , João de Souza Agostinho , Cláudio de Sousa André , Beraldo Ribeiro Drumond Diniz Nathalia
Published: February 2024

Parceria para o Desenvolvimento Produtivo (PDP) é a cooperação mediante acordo entre instituições públicas e entre instituições públicas e entidades privadas para desenvolvimento, transferência e absorção de tecnologia, produção, capacitação produtiva e tecnológica do País em produtos estratégicos para atendimento às demandas do Sistema Único de Saúde (SUS). O trabalho apresenta uma análise das contribuições da Parceria para o Desenvolvimento Produtivo no atendimento das garantias constitucionais de acesso à saúde pela população, como um direito fundamental, bem como os ganhos para a sociedade brasileira. Para isso, adotou-se a abordagem qualitativa empregando o método descritivo e analítico e o levantamento de dados feito por meio de pesquisa bibliográfica. Propõe-se o avanço no debate e nas práticas sobre as Parcerias para o Desenvolvimento Produtivo no contexto da saúde, reconhecendo sua importância estratégica para o Sistema Único de Saúde (SUS) como um mecanismo de redução das vulnerabilidades do setor, buscando a sustentabilidade tecnológica e o fortalecimento do Complexo Econômico Industrial de Saúde.
Política nacional de humanização e gestão em saúde
Authors: Zancan Jair Antônio , Canan Silvia Regina
Published: February 2024

O estudo em tela, resultado de parte de uma pesquisa de mestrado, teve por objetivo analisar os documentos que tratam sobre a qualificação dos profissionais e a gestão em saúde, visando alcançar um atendimento em saúde mais horizontalizado e humanizado, considerando a importância da construção de um modelo de atenção à saúde voltado a ampliação do protagonismo dos profissionais da área e qualidade de vida dos sujeitos. Para tanto, serão abordadas questões referentes gestão em saúde, os recursos humanos voltados para a empatia, responsabilidade e comprometimento, assim como a estrutura em saúde, evidenciando a relevância de existir um espaço acolhedor. Trata-se de um estudo bibliográfico e qualitativo. Dentre as conclusões possíveis, destacamos que a atuação transdisciplinar e as relações horizontalizadas de poder auxiliam na descentralização do caráter unitário e totalitário que é, muitas vezes, encontrado nas instituições de saúde, dessa forma é possível que haja a valorização da dimensão concreta das práticas de saúde e a transformação dos modelos de gestão e atenção.
The Big Five Factors of Personality Traits and Leadership Practices of Academic Department Chairs: A Predictive Study
Authors: Ali Assiri Mohammed
Published: February 2024

This study investigated whether the big five factors of personality traits can predict academic department chairs’ leadership practices. The study had a predictive research design; the data were collected from 424 participants in the 2023 academic year, and the instruments of this study were two questionnaires. The study found that the big five factors of personality traits predict the leadership practices of academic department chairs. Two factors of personality traits, conscientiousness and openness to experience, were statistically significant and predicted the practices in modelling leadership. Four factors (agreeableness, conscientiousness, openness to experience, and extroversion) were statistically significant and predicted leadership practices in inspiring a shared vision. Three factors (neuroticism, extroversion, and conscientiousness) were statistically significant and predicted leadership practices in challenging processes. Two factors (conscientiousness and openness to experience) were statistically significant and predicted leadership practices enabling others to act. Three factors (conscientiousness, agreeableness, and openness to experience) were statistically significant and predicted leadership practices encouraging the heart. The study recommended that academic leaders be required to consider personality traits as an important dimension in selecting and assigning academic department chairs and other academic leaders at all levels at higher education institutions.
Innovative IoT-infused games: Enhancing learning for children with autism spectrum disorder
Authors: Shyja K. G.
Published: February 2024

This paper explores the transformative potential of Internet of Things (IoT)-driven Game-Based Learning (GBL) as an innovative educational intervention for children with Autism Spectrum Disorder (ASD), a neurological condition marked by challenges in social interaction, communication, and repetitive behaviors, often presenting hurdles in traditional classroom settings. Leveraging IoT technologies, the study investigates the intersection of GBL and ASD education, synthesizing existing literature to highlight the advantages and challenges associated with this approach. By examining the impact on academic and social outcomes, the research aims to provide insights into the promising landscape of IoTdriven GBL for children with autism, paving the way for a more inclusive and tailored educational experience. This paper investigates how IoT-driven Game-Based Learning (GBL) can revolutionize education for children with Autism Spectrum Disorder (ASD), emphasizing the integration of sensor technologies, data analytics, and real-time feedback to improve their learning experience. The paper discusses ethical and privacy issues in using IoT in autism education. It explores safeguards for responsible implementation, considering the sensitive personal data involved. The research also suggests collaborative efforts among educators, technologists, and healthcare professionals for a holistic approach to IoT-driven education for autism. The paper advocates for stakeholder involvement and interdisciplinary collaboration to create effective interventions for autistic children in education. It focuses on the impact of IoT-driven Game-Based Learning (GBL) on long-term outcomes and contributes to discussions on the future of inclusive education for children with Autism Spectrum Disorder (ASD), aiming to inspire further research and dialogue on leveraging emerging technologies for equitable education.
Rural–urban variation in the utilisation of publicly funded healthcare services: an age-stratified population-level observational study
Authors: Nixon Garry , Davie Gabrielle , Whitehead Jesse , Miller Rory , de Graaf Brandon , Liepins Talis , Lawrenson Ross , Crengle Sue
Published: February 2024

aim: To compare age-stratified public health service utilisation in Aotearoa New Zealand across the rural–urban spectrum. methods: Routinely collected hospitalisation, allied health, emergency department and specialist outpatient data (2014–2018), along with Census denominators, were used to calculate utilisation rates for residents in the two urban and three rural categories in the Geographic Classification for Health. results: Relative to their urban peers, rural Māori and rural non-Māori had lower all-cause, cardiovascular, mental health and ambulatory sensitive (ASH) hospitalisation rates. The age-standardised ASH rate ratios (major cities as the reference, 95% CIs) across the three rural categories were for Māori 0.79 (0.78, 0.80), 0.83 (0.82, 0.85) and 0.80 (0.77, 0.83), and for non-Māori 0.87 (0.86, 0.88), 0.80 (0.78, 0.81) and 0.50 (0.47, 0.53). Residents of the most remote communities had the lowest rates of specialist outpatient and emergency department attendance, an effect that was accentuated for Māori. Allied health service utilisation by those in rural areas was higher than that seen in the major cities. conclusions: The large rural–urban variation in health service utilisation demonstrated here is previously unrecognised and in contrast to comparable international data. New Zealand’s most remote communities have the lowest rates of health service utilisation despite high amenable mortality rates. This raises questions about geographic equity in health service design and delivery and warrants further in-depth research.
Perceived barriers to self-collected HPV testing for cervical cancer screening, and knowledge of HPV: a survey of primary healthcare smear-takers across Aotearoa New Zealand
Authors: Ingamells Sarah , Bell Rebecca , Nip Janine , Innes Carrie , Te Whait Sarah , Tino Alex , McBain Lynn , McMenamin John , Hudson Ben , Gibson Melanie , Lawton Bev , Sykes Peter
Published: February 2024

aims: Cervical cancer remains a burden within Aotearoa New Zealand, with 2022 screening rates sitting 12.7% below target. The National Cervical Screening Programme has changed to primary human papillomavirus (HPV) testing for all screen-eligible people, with the aim for home self-testing. Little is known about the readiness of primary care for the change to self-testing and its associated challenges. A pilot HPV cervical cancer screening programme is being conducted in 17 practice centres. The aim of this study is to explore smear-taker knowledge at these centres about the use of primary HPV testing for cervical cancer screening. methods: This is an ethically approved questionnaire study, with data from a structured web-based questionnaire sent to all smear-takers at the pilot centres. results: We achieved a total completion rate of 57.8%. The average score for “Knowledge of HPV” was 56.5% (range=20–100%). The challenges to patient home HPV self-testing were felt to be overall “not at all” to “mildly challenging”. Up to 73.3% of participants identified ongoing needs for further education. conclusions: The findings indicate knowledge deficits regarding HPV testing for cervical cancer screening and a desire for the provision of further education. Overall, respondents felt that no major barriers to implementing HPV self-testing would occur.
Heart Rhythm New Zealand consensus statement on the practical management of cardiac implanted electronic devices in the peri-operative environment
Authors: Guglietta Emma , Denekamp Sharron , Sinclair Susan , Harris Lucy , Bishop Paula , Naidoo Nivashni , Holliday Timothy , Chacko Matthew , Downey Ross , Swampillai Janice , Martin Andrew , Webber Matthew
Published: February 2024

Electrosurgery is commonly used during a range of operations in order to maintain effective haemostasis. This can cause electromagnetic interference (EMI) with cardiac implanted electronic devices (CIEDs), which prevents normal device function. CIEDs include pacemakers (PPM), implantable cardiac defibrillators (ICD), cardiac resynchronisation therapy devices—both pacemakers and defibrillators (CRT-P/CRT-D)—and implantable loop recorders (ILRs). Damage to the generator, inhibition of pacing, activation of asynchronous pacing and ventricular fibrillation can all be induced by electrocautery. An active management plan for CIEDs during electrosurgery is critical to minimise these adverse effects of EMI. Purpose: To facilitate the safe and effective peri-operative management of CIED patients during electrosurgery.
Instrument Automation Control System Faults and Maintenance
Authors: Li Jianwei
Published: February 2024

This article explores the topic of fault diagnosis and maintenance strategies for instrument automation control systems, analyzing them through specific cases. The aim of this research is to improve the stability and reliability of the system by conducting a thorough investigation of faults and maintenance in instrument automation control systems. By doing so, this research hopes to provide a strong guarantee for the smooth progress of industrial production.
Enhancing Hazardous Chemical Management in Chinese University Laboratories: Strategies for Safety and Efficiency
Authors: Li Yizhe
Published: February 2024

This paper examines the management of hazardous chemicals in Chinese university laboratories, identifying keychallenges and proposing improvements. It reviews current practices and safety measures, highlighting deficiencies suchas inadequate safety systems and insufficient awareness among personnel. The study emphasizes the necessity of tailoredsafety management systems, the integration of digital tracking technologies like Radio Frequency Identification, andenhanced safety training for staff. The proposed recommendations aim to mitigate risks and enhance laboratory safety andefficiency. In conclusion, the paper asserts that a comprehensive approach, encompassing improved management systems,technological advancements, and educational initiatives, is essential for safer chemical handling in academic researchenvironments
Crossing the Achilles Heel of Algorithms: Identifying the Developmental Dilemma of Artificial Intelligence-Assisted Judicial Decision-Making
Authors: Chen Kexin
Published: February 2024

In the developmental dilemma of artificial intelligence (AI)-assisted judicial decision-making, the technicalarchitecture of AI determines its inherent lack of transparency and interpretability, which is challenging to fundamentallyimprove. This can be considered a true challenge in the realm of AI-assisted judicial decision-making. By examining thecourt’s acceptance, integration, and trade-offs of AI technology embedded in the judicial field, the exploration of potentialconflicts, interactions, and even mutual shaping between the two will not only reshape their conceptual connotations andintellectual boundaries but also strengthen the cognition and re-interpretation of the basic principles and core values of thejudicial trial system.
A Study on the Design Method of Hybrid MOSFET-CNTFET Based SRAM – A Secondary Publication
Authors: Cho Geunho
Published: February 2024

More than 10,000 carbon nanotube field-effect transistors (CNTFETs) have been successfully integratedinto one semiconductor chip using conventional semiconductor design procedures and manufacturing processes. Thesetransistors offer advantages such as high carrier mobility, large saturation velocity, low intrinsic capacitance, flexibility, andtransparency. The three-dimensional multilayer structure of the CNTFET semiconductor chip, along with ongoing researchin CNTFET manufacturing processes, increases the potential for creating a hybrid MOSFET-CNTFET semiconductorchip. This chip combines conventional metal-oxide-semiconductor field-effect transistors (MOSFETs) and CNTFETs inone integrated system. This paper discusses a methodology to design 6T binary static random-access memory (SRAM)using a hybrid MOSFET-CNTFET. This paper introduces a method for designing a hybrid MOSFET-CNTFET SRAMby leveraging existing MOSFET SRAM or CNTFET SRAM design approaches. Additionally, this paper compares itsperformance with conventional MOSFET SRAM and CNTFET SRAM designs.
Neumotórax catamenial bilateral secundario a endometriosis. Reporte de Caso.
Authors: Ortegon Candela Edwin Nicolas , Ramirez Jaimes Laura Camila , Andrade Gabalan Maria Paula
Published: February 2024

Introducción: la endometriosis torácica es una afección poco frecuente que se define como la presencia de tejido endometrial ectópico en los componentes de la cavidad torácica. El neumotórax catamenial, relacionado temporalmente con la menstruación, es un evento raro, pero puede ser una manifestación de la endometriosis torácica.
Caso Clínico: presentamos el caso de una mujer joven con repetidos neumotórax espontáneos, cuya evaluación llevó al diagnóstico de síndrome de endometriosis torácica. La intervención quirúrgica unilateral se realizó con éxito, sin embargo, la paciente presentó un nuevo episodio de neumotórax del lado contrario después de un tiempo. La identificación y tratamiento de la endometriosis es crucial para prevenir recurrencias del neumotórax espontáneo, lo que subraya la importancia de considerar la endometriosis torácica en el diagnóstico diferencial de neumotórax catamenial. Este caso destaca la necesidad de un abordaje multidisciplinario para un manejo exitoso de la endometriosis torácica.
Objetivos: exponer caso clínico de neumotórax catamenial, cuadro clínico, evolución clínica, diagnóstico y tratamiento.
Metodología: se presenta estudio descriptivo con obtención de datos de historia clínica de la paciente con diagnóstico de síndrome de endometriosis torácica, bajo consentimiento informado, además de imágenes diagnósticas de base de datos del Hospital Regional de Chiquinquirá de Colombia, el 29 de septiembre de 2022.
Conclusión: la correcta evaluación de las manifestaciones clínicas de neumotórax espontáneos en mujeres jóvenes durante su ciclo menstrual, con un enfoque clínico integral, entendiendo la enfermedad como un síndrome y no como un evento aislado, del mismo modo, la correcta utilización de recursos imagenológicos como radiografía de tórax y tomografía axial computarizada de tórax, facilitan el diagnóstico diferencial del neumotórax catamenial y asimismo el inicio temprano de tratamiento, el cual puede requerir de intervención quirúrgica, esto con el fin de educar al paciente sobre su condición y prevenir nuevos episodios de neumotórax y posteriormente mantener seguimiento ambulatorio por servicio de cirugía de tórax y servicio de ginecología.
Discusión: teniendo en cuenta la importancia de realizar un diagnóstico y tratamiento asertivo en paciente con presentación clínica de neumotórax catamenial, es importante aportar a la literatura médica sobre las diferentes manifestaciones clínicas, evitando así que continúe siendo una patología subdiagnosticada.
Conocimiento sobre la enfermedad y complicaciones en los pacientes pertenecientes a un programa de diabetes.
Authors: Salazar Florez Jorge Emilio , Arias Castro Carlos Esteban , Betancur Arango Paula Andrea , Henao Ruíz Kimberly , Restrepo Arroyave Natalia , Rodriguez Cárdenas Estefanía
Published: February 2024

Introducción: La prevalencia de Diabetes Mellitus alcanza los 476 millones de casos en el mundo y se estima que cobra cerca de 1,5 millones de vidas por año. La autogestión de la enfermedad es un aspecto fundamental para un pronóstico positivo de la misma, dado que facilita la adopción de acciones de autocuidado, reduce el estrés asociado a la enfermedad, desarrolla mayor receptividad al tratamiento y genera una percepción más positiva sobre la salud.
Objetivos: Identificar la relación del conocimiento sobre diabetes con los resultados en salud de los pacientes del programa de diabetes de un Hospital del Valle de Aburrá.
Materiales y Métodos: Estudio transversal, la población fueron adultos diagnosticados con diabetes del Hospital Venancio Diaz de Sabaneta. La fuente de información fue primaria y secundaria, las variables de salud se analizaron vía historia clínica y el nivel de conocimiento sobre diabetes fue evaluado mediante el DKQ-24. Se realizó un análisis bivariado con prueba de hipótesis a través del estadístico Chi2 y test de Fisher para su comprobación.
Resultados: 82 pacientes participaron del estudio, de los cuales el 41,46% alcanzaron un nivel adecuado de conocimiento sobre la enfermedad. La hipertensión fue la comorbilidad más prevalente, un 82% de toda la población. La retinopatía fue la principal causa de complicación diabética entre los participantes (18,29%). El nivel de conocimiento adecuado actuó como factor protector de la hospitalización (RP=0,80), pero como factor de riesgo de las complicaciones crónicas (RP=1.12). Sin embargo, ninguna de las estimaciones presentó significancia estadística.
Conclusión: Aunque el estudio no demostró relaciones estadísticamente significativas entre las variables, en general se observó que menos de la mitad de los pacientes tiene un nivel de conocimientos adecuado sobre su enfermedad, lo que invita a los profesionales de atención a generar escenarios de educación para la salud para fomentar la autogestión de la enfermedad y con ello mejorar la salud y calidad de vida de los pacientes.
Research on the use and creation of paradidactic books for teaching probability in the final years of Elementary School in Brazil
Authors: Júnior Ailton Paulo de Oliveira , Lozada Anneliese de Oliveira
Published: February 2024

The objective of this work was to systematically analyze the literature in Brazil that used or created paradidactic books for the teaching of probability aimed at the final years of Elementary School. Twelve studies were considered as results, from 2014 to 2021, and the IRaMuTeQ software was used for the multidimensional analysis from the organization in texts (corpus). Each text was prepared considering what was emphasized in the research, the methodology or methodological approach used, the context in which it was developed and the types of study and areas involved and the main results and conclusions. We emphasize that research on the use or creation of paradidactic books in the teaching of probability for Elementary School is still incipient, with the concern with the student's profile and its relations with experiential knowledge and everyday life being evidenced.
Bioakumulacja i bioługowanie Cu, Pb i Zn z odpadów górniczych
Authors: ČERMÁK Patrik , ČERŇANSKÝ Slavomír
Published: February 2024

Przedmiotem niniejszego badania było określenie skuteczności szczepów Aspergillus niger (Pezinok) i Neosartorya fischeriw bioługowaniu i bioakumulacji metali z odpadów górniczych ze stawu osadowego Hodruša. Odpady wykorzystane w pracyzawierały frakcje 0,10 mm o masie 1 i 2 g z różnych głębokości matrycy glebowej, próbki A: 10–20 cm, próbki B: 20–30 cm. Skupiliśmysię na pierwiastkach miedzi, ołowiu i cynku z zawartością poszczególnych pierwiastków (mg/kg) miedź – w próbkach A 487 mg/kg,w próbkach B 115 mg/kg. Ołów – próbki A 1208 mg/kg, próbki B 582 mg/kg. Cynk – próbki A 6970 mg/kg, próbki B 6808 mg/kg.Potwierdziliśmy skuteczność szczepu Aspergillus niger w tym procesie ze względu na produkcję kwasów organicznych (kwas cytrynowy,kwas szczawiowy, kwas octowy). W części eksperymentalnej stwierdziliśmy, że najskuteczniejszym szczepem w określaniu wydajnościekstrakcji i stężenia metali w roztworze po bioługowaniu był szczep Aspergillus niger. Szczep Neosartorya fischeri wydaje się byćnajbardziej efektywny w akumulacji metali w roztworze i akumulacji metali w biomasie. Zjawisko to można uzasadnić różnymiwłaściwościami ścian komórkowych poszczególnych szczepów grzybów i należy pamiętać o tych różnicach przy porównywaniuwłaściwości biosorpcyjnych.
Możliwość wykorzystania w technologiach górniczych niebezpiecznych odpadów wtórnych z termicznego przekształcania odpadów komunalnych
Authors: ANDRUSIKIEWICZ Wacław
Published: February 2024

Problem związany z ciągłym wzrostem ilości wytwarzanych odpadów komunalnych wymaga podjęcia zdecydowanych działańzarówno u źródła (edukacja „producentów” odpadów) jak i związanych ze sposobem ich utylizacji. Jednym ze sposobów jestprzekształcenie termiczne odpadów. Działanie to nie rozwiązuje całkowicie problemu, gdyż w efekcie procesu termicznego powstająodpady wtórne. Pozwala to jednak na znaczne ograniczenie pierwotnej masy odpadów o ok. 60–70% i objętości o ok. 80–95%. Odstrony fizycznej odpady wtórne stanowią żużle, popioły i pyły, a te – zgodnie z obowiązującą klasyfikacją – w części zaliczane są doodpadów niebezpiecznych.W artykule przedstawiono koncepcję ich wykorzystania w technologiach górniczych związanych z wypełnianiem pustek podziemnych.W tym celu należy wyselekcjonowane odpady poddać badaniom pod kątem możliwości ich wykorzystania w instalacjach odzyskuodpadów.W pracy przedstawiono wstępne wyniki badań parametrów fizycznych wybranych odpadów, a także badań chemicznych związanychz ustaleniem ich składu. Wskazano kierunek dalszych badań parametrów „technologicznych”, których znajomość będzie niezbędnana potrzeby zaprojektowania przyszłej instalacji odzysku odpadów.
Newcastle disease in local hens – A case report
Authors: Hartaputera I Nyoman Surya Tri , Kencana Gusti Ayu Yuniati , Adi Anak Agung Ayu Mira , Sudipa Putu Henrywaesa , Sulabda I Nyoman
Published: February 2024

Traditional local chicken farming, as opposed to commercial poultry breeds, faces numerous disease-related challenges, with one of the prominent threats being the Newcastle disease virus. This case report describes 8-week-old local hens infected with the Newcastle disease virus detected through epidemiological aspect, pathological, and virology investigations. The morbidity of this farm was 65%, with 20% mortality and 30.7% case fatality rate. The anatomopathology and histopathology examination revealed pathological changes in various organs. Laboratory tests using the Haemmaglutination-Inhibition and Haemmaglutination assays confirmed the presence of the Newcastle disease virus. Based on clinical symptoms, anatomopathological findings, histopathological analysis, virus isolation, and identification, it is concluded that the affected hens were infected with viscerotropic velogenic Newcastle disease.
IMPROVING PRIVATE HIGHER EDUCATION PERFORMANCE THROUGH PRACTICES OF KNOWLEDGE MANAGEMENT, LEARNING ORGANIZATION AND TALENT MANAGEMENT
Authors: Dewi Lusiana  , Rosdiana  , Ramaditya Muhammad
Published: February 2024

The purpose of this study is to identify the organizational performance formation approach used by private universities in Jakarta's LLDikti III neighborhood. Organizational performance is the dependent variable, and knowledge management, learning organizations, talent management, and entrepreneurial mindset are the independent variables. This investigation employs a survey methodology, whereby data is derived using questionnaire-based data gathering outcomes. Lecturers at private universities in the LLDikti III Jakarta region made up the study's population. In this study, 355 respondents made up the sample. SmartPLS with SEM (Structural Equation Modeling) based on PLS (Partial Least Square) is the analysis tool utilized. The study's findings indicate that while learning organizations are unaffected by knowledge management, organizational performance.
EXAMINING THE COMMODIFICATION OF POVERTY NEWS: A CASE STUDY OF KOMPAS TV’S WEBSITE, MARCH 2022
Authors: Adhrianti Lisa , Eka Vuspa Sari  , M. Hik Wahyuda
Published: February 2024

Discussing poverty in the media is intriguing, as every broadcast on the subject has the potential to evoke empathy and sympathy from the public. Additionally, commodification refers to transforming the value of a product that previously held only use value into a marketable value. This qualitative descriptive research aimed to examine the commodification of poverty presented by Kompas TV in March 2022. To collect data, observation, and documentation of poverty-related news on Kompas TV were conducted, along with interviews with communication experts and journalists. Subsequently, the collected data underwent qualitative processing and analysis to achieve the research objectives. This study yielded the following results: 1) Two forms of commodification were identified in the March 2022 edition of Kompas TV's poverty news, content commodification and immanent commodification. 2) The commodification observed occurs across three stages of television news production: the news gathering stage, the news production stage, and the news presentation stage. 3) Content commodification takes place in two stages of television news production, which are the news gathering stage and the news production stage. This is evident in the selection of topics, points of view, dramatic shooting, grouping of types of news, script editing, and video and sound editing. 4) Immanent commodification is identified at the news presentation stage, involving the production of new commodities derived from previous commodities. Furthermore, the research results lead to the following suggestions: 1) Encourage the media to prioritize poverty news, ensuring that the issue of poverty consistently occupies a prominent place in public discourse 2) Advocate for the media to amplify the voices of the poor by presenting them as individuals experiencing poverty from a human standpoint
Bird diversity and Annotated Checklist of Afrotropical species in Timiaouine, Northern Part of Adrar Ifoghas (Algeria).
Authors: Boulaouad Belkacem Aimene , Djetti Tayeb , Belkacem Mohamed , Ailam Oussama , Harzallah Bachir , Missoum Mohamed , Ayyach Khaled , Telailia Saleh
Published: February 2024

The effort to uncover avifauna in the extreme south of Algeria has been concentrated within the Timiaouine region. The region of Timiaouine is an understudied area in the extreme south of Algeria and northern part of Adrar of Ifoghas. 67 species were recorded, belonging to 32 families and 12 orders. The African Collared Dove (Streptopelia roseogrisea) recorded for the first time in Algeria. Additionally, there is a noteworthy mention of eleven Afrotropical bird species (Clamator jacobinus, Pterocles exustus, Oena capensis, Urocolius macrourus, Merops albicollis, Dendropicos elachus, Eremopterix nigriceps, Eremalauda dunni, Spiloptila clamans, Lamprotornis pulcher, Cercotrichas podobe, Passer griseus and Corvus albus) that were either newly observed or rarely documented in the extreme southern region of Algeria.