bluuebunny/crossref_metadata_2025 huggingface dataset:
Long-Term Conditioning of a Donor Heart by Autoperfusion
Authors: Zhulkov Maksim Olegovych , Zykov Ilya Sergeevich , Sirota Dmitriy Андреевич , Agaeva Hava Abdullaevna , Sabetov Azat Kerimbekovich , Poveschenko Olga Vladimirovna , Bozorov Samandar Shukrulloevich , Fomichev Alexei Vyacheslavovich , Chernyavsky Alexander Mikhailovich
Published: May 2023

The aim of research was to study parameters of homeostasis and conditions for stable operation of the autoperfused heart-lung complex ex vivo.Materials and methods. A series of acute experiments (n-3) was carried out to create a functioning heart-lung complex and study parameters of homeostasis ex vivo. A large mammal (mini-pig weighed 20-30 kg) was used as an experimental model. During the experiment, invasive blood pressure in the aortic root, pulmonary artery, central venous pressure, temperature of the left ventricle of the heart, gas composition of arterial blood (in the aortic root) and venous blood flowing from the coronary sinus was monitored.Results. The series of experiments evidenced the fundamental possibility of an isolated heart-lung complex ex vivo stable functioning. During 4-hours autoperfusion of the "heart-lung" complex, the parameters of hemodynamics, gas and biochemical blood composition remained within the reference values.Conclusion. The analysis of literature data and the results of experiments on laboratory animals allow us to state that the autoperfusion can be successfully used as an option of safe and long-term conditioning of a donor heart. This technique can be used to improve the results of heart transplantation with prolonged ischemia of the donor organ. Extending the survival of a donor heart ex vivo functioning will significantly expand the geography of donor bases, reducing the ischemic period to a minimum.
Application of the Developed Mechanical Methods for the Treatment of Patients with Wound Complications of Postoperative Ventral Hernias Prosthetic Repair
Authors: Izmailov Sergei Gennad`evich , Lukoyanychev Egor Evgen`evich , Leontev Andrey Evgen`evich , Izmailov Alexander Gennadievich , Mezinov Andrey Valer`evich , Panushkin Alexey Vyacheslavovich , Koloshein Nikita Anatol`evich , Abdulkerimov E`l`dar Magomedsherifovich , Tsyrenzhapov Agvan-Cyden Zhargalovich
Published: May 2023

Introduction. Until now, the treatment of postoperative ventral hernias and their complications remains a difficult task of abdominal surgery. Patients with extensive wound defects of the abdominal wall complicated by a purulent-inflammatory process of soft tissues are of particular difficulty for treatment; an attempt to stitch these tissues together in the II phase of the wound process using conventional options results in unnecessary trauma and makes it much more difficult, and sometimes impossible, to accurately match homogeneous layers.The aim of the study was to demonstrate the potential of successful use of the developed adaptive instruments for mechanical treatment of the wound surface and closure of a large defect in the soft tissues of the anterior abdominal wall, formed during suppuration of the surgical wound and rejection of the endoprosthesis after prosthetic repair of the hernia ring.Results. Two clinical cases of successful use of the developed adaptive instruments for mechanical treatment of the wound surface and hardware decompression suturing of wounds in the treatment of deep wound infection in postoperative ventral hernias prosthetic repair were presented. Healing of wound defects after wound suppuration and implant rejection was achieved in both cases.Conclusion. The data obtained demonstrated the safety and clinical efficacy of a staged surgical treatment with mechanical debridement of the wound, followed by vacuum therapy and the implementation of a hardware decompression technique for closing the wound defect; this creating optimal conditions for wound healing according to the type of primary intention.
Ultrasonic Diagnostics at the Stages of Liver Echinococcois Treatment
Authors: Stepanova Yulia Aleksandrovna , Goncharov Anton Borisovich , Zhao Alexey Vladimirovich
Published: May 2023

Cystic echinococcosis is a chronically severe parasitic disease of humans and animals caused by parasitism of the larval stage of Echinococcus unicameral.Ultrasound (ultrasound) being the most widely used option of visual diagnostics is the leading method of radiological diagnosis of echinococcosis of the liver and other organs. The technique is generally available and allows diagnosing echinococcosis at a stage when parasitic cysts are still small in size, starting from 1.5-2 cm. However, with the high accuracy and specificity of ultrasound in the differential diagnosis of echinococcosis cysts, there are certain disadvantages of the approach.Due to constant study and, accordingly, changes in knowledge about the course of the disease, methods for its diagnosis and treatment, there is no unified and stable ultrasound classification of liver echinococcosis. The paper analyzes the criteria that justify various classifications of echinococcus, substantiates forming trends. The standardized ultrasound classification of hydatid echinococcosis of the liver, which was adopted by the World Health Organization in 2003 and revised in 2010, is discussed.The potential and advantages of dynamic ultrasound monitoring of echinococcal cysts and postoperative characteristics of the residual cavity after echinococcectomy are demonstrated.
Surgical Treatment of Bronchopleural Fistulas on the Background of Pleural Empyema
Authors: Nikulin Andrey Vladimirovich , Gallyamov Eduard Abdulkhayevich , Diduev Gamzat Ismailovich , Surkov Anatoly Ilyich , Horobrikh Tatiyana Vitalievna
Published: May 2023

Pleural empyema (EP) is one of the most complex nosologies of thoracic surgery. Mortality in this disease reaches 28% according to the literature. The causes of the development of nonspecific empyema of the pleura are various purulent-destructive lung diseases, as well as inflammatory diseases, surgical interventions and injuries. The presence or absence of bronchopleural fistula (BPS) is crucial in determining the prognosis of treatment of pleural empyema. This article is devoted to the study of the issues of surgical treatment of BPS against the background of various EP variants. Objective. To evaluate the effectiveness of using fibrin glue as a regeneration stimulator in the treatment of patients with bronchopleural fistulas on the background of pleural empyema. Materials and methods. In the I. V. Davydovsky State Clinical Hospital No. 23, for the treatment of patients with EP complicated by the development of bronchopleural fistula, an integrated approach is used using the concept of biological stimulation of tissue repair through the use of fibrin glue obtained by cryoprecipitation. Results. Our experience based on the study of 136 patients with pleural empyema of various etiologies (post-pneumonic (n=76), post-resection (n=11), covid-associated (n=49)) shows encouraging results. The clinical efficacy of using fibrin glue as a stimulator of tissue repair was 91,89% in the group of post-pneumonic EP, 66,66% in the group of post-resection EP and 90,9% in the group of covid-associated EP. However, the results obtained require further analysis and study.Conclusion. Despite the achievements of recent decades in antibiotic therapy, the improvement of surgical techniques and new minimally invasive methods of treatment, the problem of the development of bronchopleural fistulas remains relevant to this day. Knowledge of the issues of pathogenesis, risk factors, as well as the improvement of therapeutic tactics in the development of this formidable complication will increase the effectiveness of treatment and improve the prognosis of this category of patients. The use of biological stimulators of tissue repair based on own blood plasma may be a promising direction of treatment of this complex pathology.
Negative Effects of Knee Replacement
Authors: Mansurov Jalolidin Sh. , Tkachenko Aleksandr Nikolaevich , Saiganov Sergey A. , Khaidarov Valerii M. , Urazovskaya Irina L. , Tsololo Yaroslav B. , Baranovskii Aleksei A.
Published: May 2023

Introduction Total knee arthroplasty is the treatment of choice in orthopedic practice for patients with late stage knee osteoarthritis. However, arthroplasty has not only benefit results and the service life of the endoprothesis is limited. The use of modern conservative therapy and joint-preserving surgions allowed to delay or to avoid knee arthroplasty.
Purpose. The study purpose is the analysis of publications with negative results of knee arthroplasty in patients with knee osteoarthritis.
Materials and methods. The electronic Pub-Med/MEDLINE and eLibrary databases were searched for reviews published between 2002 and 2022. A keyword search was also done using the terms: knee joint osteoarthritis, total knee replacement/arthroplasty, complications, patient satisfaction, indications/contraindications for surgery; related definitions and descriptions were extracted.
Results. The negative consequences of total knee arthroplasty are heterogeneous. Complications can be local and systemic such as surgical site infection, periprosthetic fracture, aseptic loosening (asepticinstability) of theendoprosthesis and its wearand the implant failure. The researchers data indicate increasing the number of patients who are not satisfied with the results of arthroplasty both in the short term and in the long-term after the operation, due to the natural wear of the prosthesis. Patients are not satisfied with the results of the operation 8% -30%. In recent years, there have been more publications devoted to the limitation of indication for arthroplasty in pftients with knee osteoarthritis. The replacement of the knee joint with an implant was done unreasonably in great number of cases.A number of patients after total knee arthroplasty require revision surgery within the first 5 years. Currently, the risk of failure of knee arthroplasty with the revision surgery in 10 years after primary arthroplasty is 5-6.8%. The main reasons for revision surgery after primary knee arthroplasty are periprosthetic infection and instability of the implant components, while the results of revision surgery are worse than the primary arthroplasty.
Complicated Course of Meckel's Diverticulum as a Cause of Chronic Iron Deficiency Anemia
Authors: Dvukhzhilov Mikhail Vyacheslavovich , Struchkov Vladimir Yur'evich , Markov Pavel Viktorovich , Glotov Andrey Vyacheslavovich , Akhtanin Evgeniy Alexandrovich , Goev Alexander Alexandrovich
Published: May 2023

The paper focuses on a clinical case of a complicated course of Meckel's diverticulum in a 27-year-old patient; the disease was manifested by signs of iron deficiency anemia, without signs of overt or latent bleeding. A brief review of the literature presents major features and potential complications of Meckel's diverticulum. Special attention is paid to specific diagnostic options. The authors discuss the need for surgical removal of uncomplicated Meckel's diverticulum.
Staged Restoration of Colon Continuity in an Adult Patient with a Segmental Form of Hirschsprung's Disease
Authors: Bogdanov Petr Ivanovich , Kulikov Dmitry Viktorovich , Gonchar Michail Viktorovich , Did-Zurabova Elena Sergeevna , Melnikov Vasily Valerievich , Morozov Victor Petrovich
Published: May 2023

The article presents a clinical case of the staged treatment of a patient with a functioning colostomy and a segmental form of Hirschsprung's disease. Challenges in diagnosing and determining the tactics of reconstructive and restorative surgery in appropriate cases were demonstrated in absence of adequate medical documentation.
Clinical Significance of Serum Biomarkers: Vascular Endothelial Growth Factor-A and Chemokine (C-X-C motif) Ligand 13 in Egyptian Multiple Myeloma Patients
Authors: Kassem Neemat M , Saadeldin Ibtessam , Zawam Hussam , Kassem Hebatallah A
Published: May 2023

Multiple myeloma (MM) is a human B-cell neoplasia arising from malignant plasma cells. Vascular endothelial growth factor (VEGF) is among growth factors essential for angiogenesis in MM. However, chemokine (C-X-C motif) ligand 13 (CXCL13) allows the chemotaxis of mature B cells expressing its receptor CXCR5.CXCL13-CXCR5 interactions are involved in MM progression. This study aimed at investigating 2 serum biomarkers; VEGF-A and CXCL13 levels using enzyme linked immunosorbent assays (ELISA) in 48 Egyptian myeloma patients as well as correlation with different clinic-pathological features, survival and therapy response. VEGF-A and CXCL13 levels were significantly higher in MM cases in comparison to control group (P=0.04* and 0.01*, respectively). An indirect proportional relation between VEGF-A and CXCL13 levels in myeloma patients was found (r= -0.27, P=0.22). Alb/creat ratio change showed indirect proportional relation with VEGF-A (r= -0.446, P=0.043*). Patients obtained complete remission (CR)had insignificantly lower VEGF-A and higher CXCL13 levels compared to other patients, P=0.2 and 0.7, respectively. In conclusion, production of variety of growth factors and cytokines such as VEGF-A and CXCL13 was higher in MM patients. However, our experiment has to be done on larger sample size and extended period of follow up to validate the participation of the VEGF-A and CXCL13 in disease progression and clinical outcome.
Systemic Sarcoidosis With a Pseudo-Tumoral Phenotype
Authors: Chebbi Donia , Salah Raida Ben , Frikha Faten , Fourati Héla , Ghribi Mariam , Mnif Zeineb , Bahloul Zouhir
Published: May 2023

Sarcoidosis is a systemic disease histologically characterized by the presence of non-caseating granulomas. Granulomas can affect all structures of the body, giving heterogeneous manifestations and making the diagnosis of this disease a real challenge. We report the case of a 72-year-old woman who presented with two rare manifestations of sarcoidosis: an orbital and a pulmonary pseudotumor. The orbital tumor revealed the disease. Clinically, the patient had palpebral swelling. Orbital MRI showed an orbital pseudotumor hypointense on T1, and hyperintense on T2, heterogeneous and enhanced after gadolinium injection. The thoracic localization was asymptomatic, revealed by the chest Computed Tomography (CT) scan. Histological evidence of granuloma was obtained at both locations. The level of angiotensin-converting enzyme was high. All the other systemic granulomatous diseases were eliminated. We started a systemic corticotherapy with good clinical results.
Molecular Diagnosis Challenge in COVID-19 Pneumonia Phase
Authors: Moradi Baqer , Sedaghati Javad , Abedi Ali
Published: May 2023

The Article Abstract is not available.
Evaluation Methods in Clinical Health Technologies: A Systematic Review
Authors: Mohammadzadeh Niloofar , Katigari Meysam Rahmani , Hosseini Rahil , Pahlevanynejad Shahrbanoo
Published: May 2023

Background: This study was conducted to classify the types of evaluation methods in clinical health technologies based on a systematic review method.
Methods: An electronic search was conducted in three scientific databases including Scopus, PubMed and ISI. The search strategy was performed in Jul to Nov 2021 and based on the three main concepts of "evaluation", "technology", "health. This search has been restricted to 10 years (2011-2021). Moreover, it only was limited to English and papers published in journals and conferences proceeding.
Results: Overall, 8149 references were identified for title and abstract screening. Full text screening was performed for 2674 articles, with 174 meeting the criteria for study inclusion.
Conclusion: Most of the technologies evaluated in these articles were associated with PC-based systems (N=107), and there have been fewer mobile apps (N=67). Most of used technologies were with goals of treatment (43%, N=74) and education (26%, N=45). Among all the methods, the most and the least used methods were usability (66%, N=115) and qualitative (1%, N=2) method, respectively. The most method for health clinical technologies is usability method especially in telemedicine field.
The Effect of Monovalent Influenza Vaccine on the Risk of Hospitalization and All-Cause Mortality According to the Re-sults of Randomized Clinical Trials: A Systematic Review and Meta-Analysis
Authors: Rezaei-Tavabe Nilay , Kheiri Soleiman , Mousavi Masoumeh Sadat , Mohammadian-Hafshejani Abdollah
Published: May 2023

Background: In recent years, various studies have been conducted to investigate the role of the influenza vaccine in reducing the risk of hospitalization and mortality; however, the results of these studies are clearly contradictory. Accordingly, we aimed to investigate the effect of monovalent flu vaccines on the risk of hospitalization and all-cause mortality.
Methods: This study was a systematic review and meta-analysis of Randomized Clinical Trial (RCT) studies published in databases (Web of Science (ISI), Scopus, PubMed, Cochrane, Science Direct, Google Scholar) from 1980 to Dec 2022. All analyzes were performed by Stata15 statistical software and the significance level in this study was considered 0.05.
Results: In the initial search, 375 articles were retrieved which, considering the study criteria, finally 8 RCT were included in the meta-analysis of the effects of monovalent Flu vaccine on the risk of hospitalization, and 10 RCT on the risk of all-cause mortality. Based on the results of meta-analysis, the overall Odds Ratio (OR) of hospitalization is equal to 0.71 (95% CI: 0.56-0.90; P <0.001) and the overall OR of all-cause mortality is equal to 0.82 (95% CI: 0.68-0.98; P=0.033). There was no publication bias in the study of the effect of monovalent flu vaccine on the risk of hospitalization and all-cause mortality
Conclusion: Getting the flu vaccine can reduce the risk of hospitalization by 29% and the risk of overall death by 18%. Therefore, it may be promising to receive this vaccine as a preventive intervention for deaths and hospitalizations.
The Effect of Challenge-Hindrance Stress on Psychache among Middle and Primary School Teachers
Authors: Zhang Ling , Wang Haibin , Zhang Junjie
Published: May 2023

Background: Middle and primary school teachers are experiencing considerable stress from their careers. However, previous studies on work stress among teachers focused on the influence of various types of stress on individuals but failed to explore the relationship among middle and primary school teachers’ work stress, psychache. We aimed to examine the basic conditions of the challenge-hindrance stress of middle and primary school teachers as well as its relationship with psychache and psychological resilience.
Method: A total of 512 middle and primary school teachers from Zhejiang and Anhui in China were enrolled from May to October 2021. The subjects were evaluated with the challenge–hindrance stress questionnaire, psychache scale, and psychological resilience scale. t-test, ANOVA analysis, correlation analysis, and multivariate regression analysis were used to explore the relationship between challenge-hindrance stress and psychache
Results: Middle and primary school teachers generally experience high challenge–hindrance stress and psychache. The challenge-hindrance stress had a significantly positive correlation with psychache (r=0.295, 0.439, P<0.01) and a significantly negative correlation with psychological resilience (r＝−0.320, −0.494, P<0.01). Challenge–hindrance stress could be used to significantly predict the psychache. Specifically, challenge stress and hindrance stress could significantly positively predicted the psychache (β=0.295 and β=0.439, respectively). In addition, psychological resilience exerted a partial mediating effect on the relationship between challenge–hindrance stress and psychache.
Conclusion: The challenge–hindrance stress of middle and primary school teachers influences their psychache directly as well as indirectly through the mediating effect of psychological resilience.
Evaluation of the Accuracy of the Postural Stability Measure-ment with the Y-Balance Test Based on the Levels of the Biomechanical Parameters of 14-Year-Old Girls
Authors: Chwała Wiesław , Burdacka Katarzyna , Walaszek Robert , Burdacki Marcin
Published: May 2023

Background: Dynamic balance monitoring involves the assessment of the muscular control during changes of the centre of gravity location in space above the supporting plane. We aimed to determine the structure of the Y-Balance Test and its accuracy based on measurements of strength and resistance to fatigue of muscles acting on the knee joint under static conditions, as well as joint motion ranges and static balance in girls aged 14 years.
Methods: The study included 40 girls aged 14, who attended Gymnasium No. 2 in Cracow (Poland). The research was conducted in October 2020. Postural stability was examined with the use of the YBT. The measurements of muscle strength and knee joint extensor and flexor resistance to fatigue during an isometric contraction were performed in a standard position on the test bench. The measurements of lower extremity joint range of motion were performed in accordance with the SFTR methodology. Static balance was assessed with the use of the modified FBT.
Results: The factor structure obtained for both lower extremities has satisfactorily explained the common variance (about 70%) and showed slight differences between the left and right extremities.
Conclusion: The factor structure in the group of examined girls suggests a highly hybrid nature of the Y-Balance Test with a wide spectrum of biomechanical variables that have little influence on the measurement results.
Drug-Related Poisonings among Chilean Adult Population
Authors: Schulz-Bañares Berta , González-Norambuena Carla , Müller-Ramírez Claudio
Published: May 2023

Background: Poisonings is a preventable public health problem that globally affects the population. We aimed to characterize drug-related acute poisonings occurred in Chile between the years of 2016 and 2020.
Methods: A retrospective study of poisonings among hospitalized patients was carried out. Data were obtained from the Medical Outcome Statistical Report database. Inclusion criteria were cases of patients admitted into either public or private healthcare settings with diagnosis of drug-related poisoning according to the WHO ICD-10 codes T30-T50. Statistical analyses were run to establish either significant associations or differences between variables selected in the study.
Results: Overall, 12,975 poisonings were identified during the 2016-2020 period. These events corresponded to 0.16% of all national hospital admissions in the study period. Women represented 71.1% of the cases. 76.7% of events were related to intentional poisonings while 7.3% and 16% were accidental and undetermined poisonings respectively. 44.6% of accidental and intentional poisonings occurred at the age of 18-29 yr old. Benzodiazepines (22.8%), antidepressants (11.2%), and acetaminophen (5.1) were the most common drugs associated with poisonings. Average length of hospitalization was between 3.3 and 8.2 days. 0.6% of poisonings resulted in deaths.    
Conclusion: Poisonings were characterized by patients’ sex and age, circumstance of exposure, length of hospitalization, and outcome. Poisoning rates were stable along the years with a slight decrease in 2020. Intentional poisonings among young women and men were more common. Most of the cases had favorable outcome for patients.
The Structural Relationships among Academic Pressure, Independent Learning Ability, and Academic Self-Efficacy
Authors: Zhao Chongjun , Li Jing , Kim Seung-Yong
Published: May 2023

Background: The coronavirus disease pandemic has caused significant disruption in the field of education, resulting in the need for more online classes and a blended offline and online teaching model. Therefore, understanding what makes this model effective is important. Accordingly, this study explored the structural relationships among academic pressure, independent learning ability, and academic self-efficacy in a blended teaching environment during the pandemic and independent learning ability’s mediating effect on the relationship between academic pressure and academic self-efficacy.
Methods: Adopting a random sampling method, this study surveyed 761 Chinese college, Shaanxi Province, China in 2022 and university students. Factor analysis, correlation analysis, structural equation modeling, and path analysis were used to analyze the data.
Results: The results show that the academic pressure faced by Chinese English majors had a significant negative impact on academic self-efficacy (P<0.001). However, academic pressure had no statistical effect on students’ independent learning ability (P=0.317). Moreover, independent learning ability had a significant positive effect on academic self-efficacy (P<0.001) and a mediating effect on the relationship between academic pressure and academic self-efficacy (P=0.032).
Conclusion: Independent learning ability can directly and indirectly affect academic self-efficacy. Thus, in an online and offline blended teaching model, teachers should guide students regarding self-exploration, communication, and cooperation based on existing knowledge and experience. They should also enable students to improve their learning process and independent learning ability. Various language learning situations should be established for learning English so that by experiencing success and failure, students can ultimately improve their academic self-efficacy.
Identification of Lncrna-Mrna Networks in Hepg2 Cells upon ATP7B Knockout and Copper Accumulation
Authors: Yan Yan , Xu Yin , Chen Lin , Han Yongzhu , Yang Renmin , Hu Wenbin
Published: May 2023

Background: Hepatolenticular degeneration (HLD) is an inherited disorder caused by the mutation in the adenosine triphosphatase copper transporting β gene (ATP7B). W aimed to explore the genetic changes in HLD using bioinformatics analysis.
Methods: The study was conducted in Nepal, in 2019. The GSE107323 dataset was downloaded and the differentially expressed lncRNAs (DElncRNAs) as well as differentially expressed genes (DEGs) induced by ATP7B knockout (KO) and copper toxicity were clustered using Mfuzz clustering analysis. LncRNAs and genes with high coexpression (correlation coefficient > 0.9) and pathways involving the DEGs were used to construct the lncRNA-gene-pathway network.
Results: ATP7B KO and ATP7B KO + copper induced 51 overlapping DEGs and 687 overlapping DElncRNAs, respectively. Mfuzz analysis identified four clusters, including two clusters of consistently upregulated and downregulated DEGs/DElncRNAs. The lncRNA-gene-pathway network consisted of 13 DElncRNAs, 10 DEGs, and two pathways, including “hsa04630: Jak-STAT signaling pathway” and “hsa04920: Adipocytokine signaling pathway”. Eight downregulated genes, including erythropoietin (EPO), insulin receptor substrate 1 (IRS1), and PPARG coactivator 1 alpha (PPARGC1A), and two upregulated genes (cardiotrophin-like cytokine factor 1 and cyclin D3) were involved in the two pathways. These genes were targeted by multiple lncRNAs, including PCAT6 and MALAT1.
Conclusion: Collectively, the differentially expressed lncRNA-mRNA axes play crucial roles in HLD pathogenesis through mediating cell proliferation and inflammation. Moreover, the EPO, IRS1, or PPARGC1A genes were potent therapeutic targets for HLD.
Utilization Trend of Parenteral Antidiabetic Drugs in Type 2 Diabetic Patients Covered by Iran Health Insurance Organization from 2011 to 2030
Authors: Shojaee Ali , Akbari Sari Ali , Farzadfar Farshad , Davari Majid , Daroudi Rajabali , Shajari Pour Mousavi Sayyed Masoud
Published: May 2023

Background: Exploring and analyzing the cost of medicines is an important tool for their management and planning. This study aims to analyze the utilization and costs of parenteral anti-diabetic medications during the past decade and predict the future trend of these medications from 2021 to 2031 in people that are covered by Iran Health Insurance Organization (IHIO).
Methods: This study was based on secondary analysis of data routinely reported to IHIO from 2011 to 2019. For each drug, the Defined Daily Dose (DDDs) and DDDs per 1000 inhabitants per day were calculated for the last 9 years according to the WHO protocol. Then a regression analysis was used to predict the utilization trend of each drug for the following 10 years.
Results: The overall utilization of injectable antidiabetic drugs has constantly increased during the last nine years. This increasing trend is estimated to continue during the next decade.
Conclusion: In Iran, the increase in the diabetic population and better access in the future will be the main reasons for the increase in the utilization of various insulins. The increasing trend of utilizing injectable anti-diabetic drugs in Iran might be partly due to new patients and partly because of improvement in patient access to new treatments. This also suggests that, compared to the average in the commonwealth countries, Iranian diabetic patients has faced lack of drug utilization in the past decade that is gradually reducing.
A Cheap and Simple Method for DNA Isolation from Endonuclease Producing Serratia marcescens
Authors: Niyazi Denis , Radeva Stephanie , Bozhkova Milena , Savova Dobromira , Stoeva Temenuga
Published: May 2023

The Article Abstract is not available.
The Relationship between Statins and Survival of Colorectal Cancer
Authors: Mohammadian Mahdi , Mohammadian-Hafshejani Abdollah
Published: May 2023

The Article Abstract is not available.
Explaining the causes and effective interventions in academic failure from the perspective of conditional students in University of Medical Sciences: A qualitative study
Authors: S Hashemi , A Afsharian , M Afshari , Daneshmand F Zinati , B Khademi Monfared
Published: May 2023

Introduction: Due to the lack of information about the causes of academic failure of university students, as well as the lack of knowledge of effective interventions to prevent and reduce this problem, this qualitative study aims to explain the causes and effective interventions in academic failure from the perspective of conditional students at Hamadan University of Medical Sciences.
Methods: This research was a qualitative study using descriptive phenomenology approach. The study population was conditional students who were selected through purposive sampling. Interviews with people were conducted in-person and in-depth according to their wishes. The time of each interview was 45 to 60 minutes. The information obtained from the interview was analyzed using the 7-step method of Kleiser. To increase the trust and scientific credibility of the results, Lincoln and Goba methods were used.
Results: Data analysis led to the extraction of 6 classes as effective causes of academic failure, which included academic problems, physical and mental problems, looking to the future, financial problems, us ing technology, and family and social problems. Data analysis led to 4-story extraction as an effective intervention on academic failure, including academic intervention, reduction of physical and mental problems, family and social problems, and other interventions.
Conclusion: It is useful to use interventions in the process of reducing academic dropout in students. Interventions such as proper nutrition, reducing the use of virtual space, the presence of a consultant and helping students in time management and planning, multi-stage evaluation according to the courses can be effective.
Entrepreneurship in Nursing: a literature review
Authors: F Hosseinzadeh , R Imani , A.M Chekeni , H Anvari , Gh Roozbahani , R Heidari-Soureshjani
Published: May 2023

Introduction: Nowadays, according to the variety of businesses for entrepreneurial nurses, they can have a tangible role in delivering safe, high-quality, patient-centered, accessible, and economical care through their creative activities. The current study is a review study of entrepreneurial studies to review and summarize data in the field of entrepreneurship in nursing.
Methods: In the current review study, articles in English relating to the aim of the study were searched and evaluated by using keywords related to “nurse” and “entrepreneurship” from 2000 to 2021 in various databases including Web of Science, PubMed, Factiva, EMBASE, Scopus and google scholar search engine. The search strategy was written based on Mesh terms and syntaxes specific to each database. Inclusion criteria were relating to the subject and having an accessible full text. The rest of the articles were excluded. Two researchers searched independently. After extracting articles, duplicates were excluded. Then an expert reviewed and categorized included studies.
Results: Entrepreneurial nurses need personal, interpersonal, commercial, and strategic skills. They can work as social, business, and inter-organizational entrepreneurs. However; entrepreneurial nurses have been constantly facing numerous personal, sociocultural, academic, organizational, etc. obstacles. Therefore, there must be internal and external stimuli in order to motivate them to overcome these obstacles.
Conclusion: Nurses have multiple needs in order to play they’re entrepreneurial role. Thus, it’s necessary to attempt to identify the obstacles and needs of entrepreneurial nurses and solve them to provide the necessary backgrounds for their creative activities so that they can meet the health needs of individuals and societies.
Investigating the Effectiveness of Mobile Phone-based Education on Learning Pain Management Skills in Nursing Students
Authors: G Arji , L Shahmoradi , M Panahi , M Mehrabanfar , M Saeeidi
Published: May 2023

Introduction: Nurses are the first line in assessing the patient's pain and performing palliative measures, and their proper training is essential. The aim of this study was to compare the effectiveness of lecture and mobile phone-based teaching methods on the knowledge and performance of nursing students in patient’s pain management.
Methods: The present study was a semi-experimental before and after study with two intervention and control groups. The samples included 52 nursing students in Saveh Medical Sciences Faculty. Learners were placed in two intervention (mobile based application) and control (lecture) groups by a simple random method. The data collection tool included a questionnaire to measure the level of awareness and a checklist to measure the pain management skills of patients by the learners. Mann-Whitney, paired t test and independent t test were used to data analysis.
Result: After training, students' knowledge scores about pain management increased significantly in both intervention and control groups. In addition, there was a significant difference in the mean score of pain management skill and its measurement among the learners of both groups after the intervention (P<0.05).
Conclusion: The use of a mobile-based application can improve pain management and pain measurement skills in nursing students. The correct use of these programs can improve the quality of students' learning and also improve their knowledge and skills.
Borzuya, The physician: A curriculum output of Khosravani Education
Authors: M Aghabagheri , M Mehrmohammadi , Kh Bagheri Noaparast
Published: May 2023

Introduction: Borzuya, the physician, a sage as well, is one of the prominent figures of Shahnameh in Sassanid era especially in Nushirvan court. In seeking of the immortality tree, he made a voyage to India. Such a burden to bear for memorization and its translation to Pahlavi and then dedication the work made him immortal owing to the allocation of the first chapter as Borzuya, the sage.
Methods: Regarding a method fusion of history, analysis, and education, the germane sources were reflected upon and some presuppositions were critically pondered as the similarity of Borzuya and Bozorgmehr. However, these names are two distinguished figures in Shahnameh, a physician and a minister, respectively. Regarding, the concept of development is not allocated to one facet, but it is multifaceted. Also it must be noted that the true outreach won’t come but with comprehensive and true thinking, design, edit, execution and assessment.
Results: First, the education of Ancient Persia is categorized as an educational archetype due to interaction of Iranian civilization with its east and west civilizations. Second, the educational implications of Shahnameh can be represented in different levels; basic (art and wisdom education) and supreme (intuition and immortality education).
Conclusion:  One of the principles of education including medical education is allocated to the role model presentation for the students. Owing to the personality of Bozuya who was a famous physician and furthermore he was an expert in philosophy, linguistics, literature, and logic, he can be presented as an appropriate role model for any contemporary learner.
Feasibility of implementing a performance monitoring system for health information technology students during the internship
Authors: S Jalali , H Ehtesham
Published: May 2023

Introduction: In universities of medical sciences, due to the key role of human resources in people's lives, their training during the internship period is of particular importance. Considering the role of effective assessment of the quality of students' performance, this research has been carried out with the aim of feasibility of implementing a system for monitoring the performance of health information technology students during internship.
Methods: This research is descriptive-cross-sectional and among applied studies that was conducted in 1401. The data collection tool was a researcher-made questionnaire with 5 sections including background information and technical, organizational, human and legal dimensions, and the research population was the professors of the health information technology department at the country. The questionnaire was sent via email and finally, the data of 20 completed questionnaires were analyzed using SPSS software version 16 by descriptive statistics method.
Results: The highest average scores for the possibility of implementing the performance monitoring system during internship was related to the legal dimension with 82.3%. And then there were the technical dimension with 80.6%, the organizational dimension with 79.6% and finally the human resource dimension with an average of 76.6%.
Conclusion: It is possible to implement the performance monitoring system of health information technology students during internship from technical, organizational, legal and human resources aspects and considering the importance of the internship period and the effective role of performance monitoring tools in the management of activities, it is suggested that necessary measures be taken to implement this system.
Necessity of teaching nanotechnology concepts in dentistry, checking the upcoming conditions due to the high speed of changes
Authors: S Amirpour haradasht , M Shahraki
Published: May 2023

The Article Abstract is not available.
La Gestión de las Artes Visuales: Artistas-etc., Gestiones Autónomas, Profesionalización y Trabajo en la Ciudad de Córdoba
Authors: PETRONI ILZE GABRIELA , MARTÍN PEREYRA LUCAS
Published: May 2023

Esta ponencia introduce algunas consideraciones de índole teórica sobre la investigación titulada Prácticas artísticas, profesionalización y trabajo: el caso de las gestiones autónomas de la ciudad de Córdoba (2015-2019). Es así que, en esta oportunidad, nos centramos en esclarecer brevemente las distinciones en torno a las categorías de trabajo, labor, empleo, actividad y desempleo; para luego describir –también sucintamente– las problemáticas que dificultan la precisión en el análisis del sector artístico-visual por parte de la administración pública (en sus diferentes niveles) junto con la incidencia de la educación artística en la formación profesional de su comunidad de estudiantes. En un cuarto momento nos detendremos a considerar algunas de las problemáticas de los espacios/iniciativas autónomas, los límites de la noción de “autonomía” y su vinculación con las prácticas artísticas.

Palabras clave: gestión autónoma, artista-etc., trabajo, profesionalización, arte visual
Indicadores de qualidade na educação superior brasileira
Authors: Lopes Marcus Vinícius de Sousa , Guimarães Jairo de Carvalho
Published: May 2023

O presente estudo tem o propósito de analisar o indicador de qualidade dos cursos de Graduação na modalidade ensino a distância da Universidade Federal do Piauí (UFPI), por meio da percepção dos discentes nos questionários obtidos no ENADE no período de 2014, 2015, 2017 e 2018. Quanto ao objetivo específico, visa desenvolver uma análise crítica acerca dos dados obtidos, no que concerne ao contexto avaliativo dos Cursos de Graduação EaD/UFPI, adaptado para a escala de desempenho da Educação Superior (HEdPERF), desenvolvida por Firdaus (2005). Tomam-se por base teórica as indicações de Dias Sobrinho (2008), Griboski (2012), Morosini (2014), Ristoff (2019), os quais discorrem sobre avaliação e qualidade da Educação Superior. O estudo tem abordagem quantitativa, e é desenvolvido, a partir de pesquisas bibliográficas e documentais com base nos dados do ENADE. Nas análises realizadas, constatou-se, entre todas as cincos dimensões analisadas no decorrer da pesquisa, os cursos de Ciências Biológicas com (5,45) e com Filosofia (4,94) encontram-se com as melhores médias, já os cursos de Bacharelado em Administração e Sistemas de Informação possuem as menores notas nas médias gerais, o primeiro com (4,13) e o segundo com (4,15). Isso demonstra que há cursos com pontos, no decurso das dimensões analisadas, que precisam de uma maior atenção por parte da gestão. Logo, o presente estudo teve o intuito de auxiliar os gestores para a orientação nas tomadas de decisões e de planejamento das ações de melhoria contínua da qualidade da Educação Superior a Distância nas IES públicas.
Professores readaptados do município de Mossoró/RN
Authors: Fernandes Aleksandra Nogueira de Oliveira , Silva Maria Jarleide da , Souza Francisca Leidiana de
Published: May 2023

Este estudo objetiva discutir a relação estabelecida entre a precarização do trabalho e o adoecimento do professor readaptado da rede municipal de Mossoró/RN. O adoecimento de professores no exercício da profissão, tem sido cada vez mais objeto de estudos por parte de pesquisadores. O trabalho é de caráter qualitativo, compreendendo uma revisão bibliográfica, a fim de se conhecer o processo histórico do adoecimento dos professores, as causas e as consequências, e realiza entrevistas com seis professoras da rede municipal de Mossoró. Os dados obtidos e analisados, revelaram que a atuação do docente nas instituições, vem gerando cada vez mais a incidência de problemas de saúde, tanto no início como no final do percurso profissional.
Cognitive impairment and its treatment in patients with multiple sclerosis
Authors: Zabirova Alfiia K. , Bakulin Ilya S. , Poydasheva Alexandra G. , Zakharova Mariya N. , Suponeva Natalia A.
Published: May 2023

Cognitive impairment (CI) is a relatively common manifestation of multiple sclerosis (MS), which can occur with any type of the disease course and activity. The largest CI prevalence and severity are observed in progressive MS. In relapsing-remitting MS the most prominent deterioration of cognitive functions is seen during relapses; however, in some patients it can continue also throughout remission. In a small number of patients CI can be the most significant symptom of the disease; in addition, it sometimes can be the only clinical feature of the relapse. Despite this, in clinical practice CI remains out of the focus of attention, and is not evaluated when assessing the disease severity and/or activity, while CI is not included into EDSS. Nonetheless, a number of specialized neuropsychological tests and batteries has been developed recently, which can be used for both screening and detailed assessment of CI in MS, as well as for assessment of its changes over time. CI has a negative impact on MS patients' quality of life, their social interactions, daily and occupational activities. The influence of disease-modifying agents on CI has been poorly investigated; however, there is evidence that they can reduce the degree of CI. The optimal choice of pathogenetic treatment in patients with CI remains understudied. There is no convincing evidence of the effectiveness of symptomatic pharmacological treatment of CI in MS, and cognitive rehabilitation is the only approach with confirmed effectiveness. Considering the limitations of this technique (its availability, quite a big number of sessions), there is a need to search for other methods to increase its efficacy, including non-invasive neuromodulation (in particular, transcranial direct current stimulation or transcranial magnetic stimulation). This article is focused on a brief review of the main diagnostic methods of CI in MS, its pathogenetic and symptomatic treatment, and cognitive rehabilitation techniques, as well as on the results of the studies on non-invasive neuromodulation.
Choques externos en la economía peruana: un enfoque de ceros y signos en un modelo BVAR
Authors: Ganiko Gustavo , Jiménez Alvaro
Published: May 2023

Este trabajo cuantifica el impacto de un conjunto de choques externos sobre la economía peruana, los cuales son caracterizados como: i) demanda, ii) oferta, iii) financieros, y iv) precios de exportación. Utilizando datos entre 1995 y 2019, se estiman modelos VAR bayesianos con bloque exógeno, los cuales son identificados mediante restricciones de ceros y signos. Los resultados sugieren que la economía peruana está altamente expuesta a choques externos, los cuales explican alrededor del 60% de la varianza de las variables domésticas. A partir del análisis de descomposición de varianza del error de predicción, descomposición histórica, y funciones impulso-respuesta, se encuentra que los choques de demanda externa son los más relevantes para explicar la dinámica del PBI doméstico, la inflación y el tipo de cambio. Los choques de oferta externa tienen un mayor efecto sobre la inflación local, mientras que choques financieros externos tienen efectos más relevantes y duraderos sobre la tasa de interés doméstica. Por último, los choques de precios de exportación tienen efectos significativos sobre la devaluación cambiaria.
Real-Time Soil Monitoring with IoT Enabled System for Crop Prediction
Authors: Pandey Yudhishthir , Khan Mohammad Faisal , . Vishal , pandey Ashish Kumar , Singh S. P.
Published: May 2023

Background: Sustainable crop production in the vast populated countries such as India has always been challenging problem since ancient times. The mismanagement of crops has led to reduced yields. It is of utmost important to study the Soil conditions and predict the suitable crop for cultivation under such conditions. Methods: In the present investigation a gadget is developed based on IoT and Arduino to monitor the soil based on parameters like pH, temperature and moisture, which helps in identifying soil conditions and decide the suitable crop and their management practices. For this purpose, the dataset of different crops has been passed with their parameters. Blynk application is used for remote monitoring. Hence the user can remotely view sensor data, log and view data, etc. Result: The results suggested that even after 24 hours of irrigation the black soil holds the high volumetric moisture. The device was correctly able to identify the suitable crops under the investigating environment viz Wheat, Lemon and Sunflower for Black soil. The system recommends the type of fertilizers that may be used and also the microbial condition of the soil. The system would enable farmers for better selection of crops under different conditions.