bluuebunny/crossref_metadata_2025 huggingface dataset:
Intencja autora i interpretacja – między inwencją a atencją. Teksty i parateksty
Authors: Szajnert Danuta
Published: August 2022

Książka przedstawia historię dysputy nad intencjonizmem, toczącej się po dziś dzień przede wszystkim w angielskim kręgu językowym. Proponuje systematykę intencyjności związaną z podmiotowo-tekstowym i zarazem sytuacyjno-idiokulturowym usytuowaniem intencji, tj. uwolnieniem jej od potocznych kategoryzacji jako przedtekstowego zamiaru o epizodycznym, mentalnym statusie. Zawiera analizy autorskich paratekstów oraz sposobów wyzyskiwania dostarczanych przez nie informacji w praktyce interpretacyjnej i prointencyjne interpretacje różnorodnych utworów literackich ilustrujące istotne rozróżnienie między autorskim dziełem i zdekontekstualizowanym, zdepersonalizowanym tekstem. Racjonalna argumentacja na rzecz tezy o uprzywilejowaniu autorskiego kontekstu motywowana jest tutaj ostatecznie względami etycznymi – w myśl przekonania o aksjologicznym uwikłaniu nie tylko naszych, zawsze interpretacyjnie zapośredniczonych, poznawczych kontaktów ze światem, ale też interpretacji samej interpretacji.
Audiodeskrypcja dzieł sztuki. Metody, problemy, przykłady
Authors: Pawłowska Aneta , Sowińska-Heim Julia
Published: August 2022

Autorki książki przedstawiły problem wyrównania szans osób niewidomych i niedowidzących w dostępie do dóbr kultury. Zaprezentowały metodę tworzenia audiodeskrypcji dzieł w kontekście upowszechniania sztuki wśród osób z dysfunkcjami wzroku. Ponieważ tworzenie audiodeskrypcji wymaga znacznego zasobu zróżnicowanej wiedzy, zaproponowały wprowadzenie specjalistycznych zajęć z audiodeskrypcji prowadzonych metodą projektową. [...] Zebrany w ten sposób materiał stał się ważnym uzupełnieniem książki, a zarazem pozwolił na cały szereg istotnych sformułowań związanych z teorią i praktyką tworzenia audiodeskrypcji. Ta pionierska praca jest istotną pozycją dla studentów, muzealników i wszystkich zainteresowanych ułatwianiem osobom z niepełnosprawnością wzroku, niewidomym i niedowidzącym dostępu do sztuk plastycznych, a tym samym integracji społecznej w obszarze kultury. Z recenzji prof. Ryszarda Hungera
Effect of Seed Rate and Seed Spacings on Yield Attributes of Chickpea
Authors: Loria Kajal , Kumari Manju , Sood Yachna , . Vikas , . Lalita , Rani Saroj , . Himangini
Published: August 2022

Background: Chickpea is a cool season legume crop and is grown in several countries worldwide as a food source. Seed is the main edible part of the plant and is a rich source of protein, carbohydrates and minerals especially for the vegetarian population. The current study aimed to study the effect of seed rate and seed spacing on yield attributes of chickpea. Methods: The research was carried out at Research Farm, Department of Agriculture, Maharishi Markandeshwar University, Sadopur, Ambala during Rabi season in 2020-2021. The experiment was laid out in split plot design (SPD), with three replication and 9 treatments with two conditions i.e. three different seed rate (60, 75 and 90 kg/ha) and seed rate were design in main plot, where as in sub-plot three spacing (20, 30 and 40 cm) were tested. Result: The result revealed that seed rate of 75 kg/ha with row spacing of 30 cm in chickpea crop recorded maximum seed index (21.70 g), seed yield (23.26 q/ha), straw yield (26 q/ha), biological yield (49.16 q/ha) and harvest index (47%). The maximum number of pods per plant (107.63) and seeds per pod (2.13) were observed when the seed rate of 60 kg/ha and row spacing of 40 cm was used.
Weed Management Efficacy of Mulches, Planting Methods and NAA Application in Capsicum annuum L. under Mid Hills of Himachal Pradesh
Authors: Bijalwan Priyanka , . Shilpa , Shukla Y.R. , Thakur K.S. , Gupta Meenu
Published: August 2022

Background: Sweet pepper is one of the most popular vegetables cultivated worldwide, which yield and quality is highly affected by weeds. Synthetic mulches and raised beds are a part of a wide strategy of integrated weed management in vegetable production systems. Methods: A field experiment was carried out in Dr YSP UHF, Nauni, Solan (HP) for two years to evaluate the effect of polythene mulches, planting on raised beds (RB) and Naphthalene acetic acid (NAA) application on weed management and yield of sweet pepper (Capsicum annuum L.) crop. Result: The interaction effect of raised bed (RB) + black polythene mulch (BPM) + NAA has recorded less weed density, greater weed control efficiency (64.12%) and lower dry weed biomass (117.83 g/m2). However, highest yield (38.47 t/ha) of sweet pepper was recorded with raised bed (RB) + silver polythene mulch (SPM) + Naphthaleneacetic acid (NAA).
Outcomes of a Quality Improvement Project: Screening for Adverse Childhood Experiences in Medication-Assisted Treatment
Authors: Pykare Justin D. , Knox Louise H.
Published: August 2022

Background

Adverse childhood experiences (ACEs) are traumatic childhood events that alter biopsychological markers of the human body, causing significant damaging lifelong effects and increasing health risk behavior, including substance use disorder (SUD).

Objective

This project evaluated an ACE screening tool in medication-assisted treatment (MAT) patients at a federally qualified healthcare center (FQHC) via a handheld patient tablet.

Methods

All MAT patients received the 10-question Kaiser Permanente ACE screening tool; 192 patients (N) (98 men and 94 women) completed the ACE screening. Age and gender demographics were collected. Pre- and post-ACE screening behavioral health (BH) referral rates were measured utilizing electronic health record (EHR) reports. After 3 months, post-ACE screening BH referral rates were compared to pre-ACE screening rates from the same 3 months of the previous year.

Results

Post-ACE screening increased BH referrals by 29.76%, a statistically significant finding (z < .00001).

Conclusion

Screening for ACEs in MAT clinics is an effective trauma-informed intervention to increase BH referrals.

Implications for Nursing

Using technology to incorporate ACE screening in MAT is feasible and provides a deeper understanding of a patient’s mental health and trauma history.
The Political Economy of Trade Barriers in Peru
Authors: Tello Pacheco Mario
Published: August 2022

This paper analyzes the political economy factors and actors that may have influenced trade instruments in Peru during the liberalization period of 2001-2015 (which started in 1990 under Fujimori’s administration). The evidence supports the hypothesis that Peruvian trade barriers liberalization in period 2000-2015 was led by the powerful “Ministry of Economy and Finance (MEF)”, accompanied by traditional and diversified exporters (that consolidated the unilateral trade liberalization) and by import substitution firms that influenced to some degree, and slowed down the rate of liberalization of unilateral trade barriers. In addition, the unilateral trade liberalization was facilitated by the weak role of the formal labor force and liberal-oriented consumer interest groups.
La inflación en Colombia y los posibles escenarios futuros
Authors: Vallejo Zamudio Luis Eudoro
Published: August 2022

La inflación es el incremento continuo y sostenido en el nivel general de precios, y su control es uno de los objetivos fundamentales de la política económica en cualquier país, dados los efectos que tiene en la economía y en la sociedad. En primer lugar, afecta el poder adquisitivo de las personas, en la medida en que se reduce su capacidad de compra, es decir, tendrán menos ingresos para cubrir sus gastos. De esta forma, la inflación actúa como un impuesto regresivo, en la proporción en que afecta los ingresos de la población, en especial de la más pobre, que ve cómo dichos recursos se reducen. En segundo lugar, genera una redistribución forzada del ingreso, debido a que los productores trasladan el incremento de precios al consumidor final; este resultado tiene repercusiones más notorias en los asalariados, sobre todo en quienes poseen bajos niveles de remuneración. En tercer lugar, afecta, inevitablemente, la competitividad de un país, puesto que, si la inflación es más alta que la de sus socios comerciales, los bienes y servicios del país que tienen precios altos no serán atractivos en los mercados internacionales.
THE INNOVATION OF THE MINI TUBERCULOSISI SPUTUM EXAMINATION PROGRAM (MPIS-TB): A PILOT STUDY AT THE BANJARSENGON COMMUNITY HEALTH CENTER, JEMBER REGENCY
Authors: Ade Grysha Viofananda Agung Kharisma , Kurdi Fahruddin , Mahardika Risha Putri , Ulya Faizatul , Yensya Gevin , Naristiti Nadya Rahmania
Published: August 2022

In the era of the Covid-19 pandemic, the fear and anxiety of families of TB-positive patients increased, making it difficult for the sputum investigation program. Not coughing with phlegm, fear of being diagnosed with Covid-19, and feeling physically healthy are obstacles to the screening process. The aim of the study was to compare the sputum pots between the control and intervention groups in the innovation of the Mini TB Sputum Examination Program (MPIS-TB) in the Banjarsengon Community Health Center, Jember Regency. Quasy experimental with post test on 2 group design was using. This pilot study on 13 participants (6 different families) became group control ad intervention. Quickcheck Covid-19 East Java Provincial Health Office and SRQ-29 are used as a tool to approach the community to understand the differences in the diagnosis of TB and Covid-19. Effective cough therapy, chest physiotherapy, and simple inhalation for 3 consecutive days were also given to all participants to facilitate sputum production and release stimulation. The study results were 15,38% sputum pots were identified to return to the health center for laboratory analysis, 53,84% sputum pots returned intact (sealed sterile), and 30,76% sputum pots returned without sterile seals. The lack of return of sputum pots in 11 participants (84.6%) was due to several factors, namely not coughing with phlegm, fear of being diagnosed with Covid-19, and not feeling TB symptoms. The implementation of the MPIS-TB Program Innovation was successful with a sputum return ratio in the intervention and control groups of 40%: 0% so that in the future this program could be considered to be applied to the TB public health center program.
Sphenoid sinus foreign body following airbag deployment in the United States: a case report
Authors: Olson Birk J. , Vella Joseph B. , McCormick Justin P.
Published: August 2022

We report a unique case of penetrating foreign bodies following a motor vehicle accident with airbag deployment. The patient presented with evidence of facial trauma and was found to have three retained foreign bodies on imaging. Notably, one foreign body was within the sphenoid sinus. This foreign body was removed uneventfully through endoscopic sinus surgery. The patient was doing well at follow-up visits. We concluded that the foreign bodies were steering wheel accessories, which detached upon airbag deployment and penetrated the patient’s face. This case report is intended to inform the public regarding the dangers of placing accessories on a steering wheel.
Antecedents of E-Learning Readiness and Student Satisfaction in Institutions of Higher Education during the COVID-19 Pandemic
Authors: Siregar Eveline
Published: August 2022

The low levels of readiness for e-learning, followed by the low satisfaction levels experienced by university students during the COVID-19 pandemic, is a crucial yet confounding issue. Many reports relate the lack of technological competence and motivation to this problem. This study examined aspects of technological competence and motivation as antecedent factors that affect student user and e-learning readiness. In addition, the study also tested the determination of the role of e-learning readiness as a mediator of the indirect influence of technological competence and motivation on student satisfaction. The study involved 1228 university students from the province of Yogyakarta, Indonesia. Data collection was assisted by using a closed questionnaire with a five-point Likert scale tested for validity and reliability. Structural Equation Modeling was used to analyze the data through path analysis and bootstrap methods. This study showed that technological competence and motivation significantly affected e-learning readiness and user satisfaction. Furthermore, e-learning readiness was seen to act as a significant mediator in the indirect effect of technological competence and motivation on student satisfaction. Therefore, these results strengthen the theory that shaping student satisfaction in e-learning requires mature e-learning readiness. In forming this readiness, technological competence and balanced motivation are needed.
Relationships of Demographic and School Related Variables to Curriculum Improvement Skill Scales for Graduating Business Students
Authors: Blau Gary , Drennan Rob B.
Published: August 2022

Business schools continue to monitor student perceptions of their curriculum during the ongoing pandemic. 274 graduating business seniors filled out a Spring 2022 exit survey asking their perceptions about the business school’s curriculum improving their abilities on twelve goals. A factor analysis of these twelve individual items resulted in keeping all items and creating three smaller scales (items/scale): Business Problem Solving (6 items), Presentation Skills (3 items) and Team-related Skills (3 items). These three scales were found to be reliable and sufficiently distinct from each other. Overall, students perceived that the business school’s curriculum improved their team-related skills significantly more than business problem solving and presentation skills. Grade Point Average or gender were not related to any scale improvement differences. Paired t-test results included finding that transfer students indicated significantly higher improvement on business problem solving and team-related skills than non-transfer students. In addition, non-quantitative majors showed higher improvement on presentation skills than quantitative majors. A stronger baseline for these three curriculum improvement scales has now been established for follow-up monitoring. Results are further discussed.
Trans-Differentiation of Non-Stem Cells to Nerve Cells or Neural Stem Cells through MicroRNA Reprogramming
Authors: Foroughi Nezhad Amin , Dehghan Sina
Published: August 2022

Brain stem cells (neural stem cells or NSCs) and neurons of a chosen kind reprogramming is a potential technique for cell therapy. It is possible to reprogram non-neuronal cells, for example, by using a predetermined group of factors, nuclear transfer, and the induced transcriptional factors (TFs) expression in a related lineage of cells, and non-coding microRNAs (miRNAs). Researchers have additionally been attempting to improve reprogramming methods, whether it is by employing unique sets of biomolecules and particular TFs or by delivering relevant miRNA and Biomolecules. The technique of miRNA mediated is intriguing for its capability to quickly create a range of biologically desirable cell types for therapy from different lineages of cells. Current findings have made significant advancements towards changing the somatic cells to diverse particular neuronal subgroups with greater efficiency, using reprogramming of miRNA-mediated neural cells, despite the fact that the precise processes need to be discovered. To further understand how miRNAs might direct somatic cells to become neural, we need to look at the latest research on their function in neural reprogramming over the differentiated cells. Recent findings on the role of miRNAs in the initiation of cell reprogramming and the determination of the neuronal subtype's destiny are the primary focus of this comprehensive overview. Furthermore, we cover the far more latest results concerning certain miRNAs' activity in controlling different phases of neuronal differentiation, which contributes in comprehending the interaction network of miRNAs and their receptors.
A Non-enzymatic Electrochemical Sensor of Cu@Co-MOF Composite for Glucose Detection with High Sensitivity and Selectivity
Authors: Ma Zhen-Zhen , Liu Bing , Jiao Huang , Xu Ling
Published: August 2022

The integration of metal nanoparticles and solid carriers can achieve ideal stability, high load and good conductivity. In this work, copper nanoparticles (Cu NPs) were sequentially deposited on a cobalt metal-organic framework (Co-MOF) by bonding with exposed imino groups, followed by a reduction reaction to prepare a new Cu@Co-MOF composite. Cu@Co-MOF acts as a non-enzymatic electrochemical sensor to detect glucose (Glu) in an alkaline medium. The composite working electrode of Cu@Co-MOF/GCE (GCE = glassy carbon electrode) improves the electrocatalytic activity for Glu oxidation. Cu@Co-MOF/GCE shows excellent electrocatalytic performances in Glu concentration ranging 0.005~1.8 mmol∙L−1 (mM): the sensitivities are 282.89 μA∙mM−1∙cm−2 in 0.005-0.4 mM Glu and 113.15 μA∙mM−1∙cm−2 in 0.4-1.8 mM Glu respectively with low detection limit of 1.6 μM (S/N = 3) and high selectivity and stability.
Range Evaluation of a Point-to-point Link using Software Defined Radio
Authors: Chan Renzo , Tincopa Jean Pierre , Pimentel Juan , Baltuano Oscar
Published: August 2022

A software defined radio (SDR) is a communication system that makes use of components that can be configured through software, in contrast to traditional systems where these components are variable through hardware, these radio devices are much more versatile, this article describes the factors that must be considered when implementing a communication system based on Software Defined Radios (SDR), in order to reduce the attenuation factors and thus obtain the maximum distance for a transmission of data effectively in the UHF band. The calculations made for the first Fresnel zone and for the design of the Ground Plane type antennas used in the transmission/reception stages of the x40 bladeRF platforms are also presented. The tests were carried out at the facilities of the Huarangal Nuclear Center of the Peruvian Institute of Nuclear Energy, obtaining favorable results that allow ratifying the versatility and performance of the SDRs.
Improving Hazardous Gas Detection Behavior with Palladium Decorated Sno2 Nanobelts Networks
Authors: Araújo Estácio P. de , Paiva Murilo P. , Blanco Kate C. , Chiquito Adenilson J. , Amorim Cleber A.
Published: August 2022

When present in specific amounts in the air, the colorless, odorless, and tasteless gases monoxide and carbon dioxide may either replace oxygen in red blood cells (CO) or increase the respiratory rate causing cardiac arrhythmias (CO2), leading to death. Commercial sensors take around 8 h to detect levels of CO (50 PPM), causing moderate poisoning. SnO2 presents controlled interactions with the atmosphere using conductance and vacancy adjustments to capture electrical properties. However, the selectivity of gas detection by SnO2 can still be improved, thus also increasing the application possibilities. The present study aimed to optimize the sensing of CO and CO2 in SnO2 using palladium functionalization. The vapor-liquid-solid method synthesized a network of SnO2 nanobelts decorated with palladium nanoparticles. The sensitivity of the sensors for CO and CO2 were evaluated, characterizing parameters such as response time, a wide range of CO and CO2 concentrations, and temperature. In the seventh measurement cycle, the sensor response for different concentrations of gases in consecutive cycles showed a sensitivity of up to 125% for CO in 60 s. Furthermore, we observed increased sensor sensitivity with material doping with nanoparticles from 130 ppm to 1360 ppm in 30 seconds to CO. Conclusion: The results provide a better understanding of the sensitivity of SnO2 in palladium-decorated nanoparticles, offering insights for detecting low CO concentrations quickly. The behavior of these doped nanosensors showed us the importance of considering them as a practical possibility for detecting these gases of importance to human health.
Analisis Kontrastif Struktur Kalimat Arab Dan Indonesia Serta Implementasinya Dalam Pembelajaran
Authors: Umam Mustolikh Khabibul , Kuswahyuningrum Diah Ayu
Published: August 2022

This study aims to compare the pattern of the Jumlah Ismiyyah and Fi'liyyah in Arabic with subject+predicate in Indonesian in terms of meaning and provisions and its implementation in several appropriate methods. This study uses a qualitative method with a library research approach. Data collection uses the documentation method. The data analysis technique uses contrastive analysis that compares the pattern of the number of Ismiyyah and Fi'liyyah in Arabic with subject+predicate in Indonesian in terms of meaning and provisions. The results show: Among the similarities and differences in the number of Ismiyyah and Fi'liyyah and 'subject+predicate' are: a) the pattern of the number of ismiyyah such as the sentence "Zaidun Ja'a" has the meaning always and remains in the sentence, while in Indonesian it only has meaning "Zaid is coming" only. b) The number of Ismiyyah has provisions between mubtada 'and khabar must be compatible in terms of mufrod, tasniyyah, and jama'. While the arrangement of the predicate subject in Indonesian does not require harmony in this regard and c) The number of fi'liyyah "Ja'a Zaidun" has a new meaning in the sentence, while in Indonesian it only means "Zaid comes". 2) the implementation of this contrastive analysis can be applied in learning the lecture and demonstration methods.

 

Abstrak

Penelitian ini bertujuan untuk membandingkan pola jumlah Ismiyyah dan Fi’liyyah dalam bahasa Arab dengan subjek+predikat dalam bahasa Indonesia dari segi makna dan ketentuan serta implementasinya pada beberapa metode yang sesuai. Penelitian ini menggunakan metode kualitatif dengan pendekatan library research. Pengumpulan data menggunakan metode dokumentasi. Teknik analisis data menggunakan analisis kontrastif yang membandingkan antara pola jumlah Ismiyyah dan Fi’liyyah dalam bahasa Arab dengan subjek+predikat dalam bahasa Indonesia dari segi makna dan ketentuan. Hasil penelitian menunjukkan: Di Antara persamaan dan perbedaan jumlah Ismiyyah dan Fi’liyyah dan ‘subjek+predikat” adalah: a) pola jumlah ismiyyah seperti kalimat “Zaidun Ja’a” memiliki makna selalu dan tetap dalam kalimatnya, sedangkan dalam BI hanya memiliki arti “Zaid datang” saja. b) Jumlah Ismiyyah memiliki ketentuan antara mubtada’ dan khabar harus serasi dalam segi mufrod, tasniyyah, dan jama’. Sedangkan susunan subjek predikat dalam BI tidak mengharuskan keserasian dalam hal tersebut dan c) Jumlah fi’liyyah “Ja’a Zaidun” memiliki makna baru dalam kalimatnya, sedangkan dalam BI hanya sekadar memiliki arti “Zaid datang” saja. 2) implementasi analisis kontrastif ini dapat diterapkan di pembelajaran pada metode ceramah dan demonstrasi
Risk factors and mortality of carbapenem-resistant Klebsiella pneumoniae bloodstream infection in a tertiary-care hospital in China: an eight-year retrospective study.
Authors: Yang Hang , Ma Hua , Huang Xiaoming , Cui Yanhui , Peng Wenzhong , Zhu Fei , Ma Shiyang , Rao Mingjun , Zhang Peipei , Su Longxiang , Pan Pinhua , Chen Jie
Published: August 2022

Background
The prevalence of carbapenem-resistant Klebsiella pneumonia bloodstream infection (CRKP-BSI) is increasing worldwide. CRKP-BSI is associated with high rates of morbidity and mortality due to limited antibiotic choices. Here, we aim to identify the prevalence and risk factors for infection and mortality of CRKP BSI.
Methods
This was a retrospective study of the past data from January 1st, 2012 to December 31st, 2019 of adult patients with KP-BSI in Xiangya Hospital, China.
Results
Among the 706 incidences included in this study, 27.4% of them (212 / 753) being CR-KP strains. The occurrence of CRKP-BSI was increased from 20.69 to 37.40% from 2012 to 2019. Hematologic malignancies and ICU acquired infection were identified to be substantial risk factors of carbapenem resistance. The overall 28-day mortality rates of CRKP-BSI patients was significantly higher than that of CSKP-BSI (P < 0.001). Logistic regression analysis identified severe sepsis or septic shock incidents, inadequate empirical antimicrobial therapy and corticosteroids use preceding infection onset as the independent predictors of 28-day mortality of CRKP-BSI patients. However, high dose carbapenem combination therapy was identified as anticipated factors of low 28-day mortality.
Conclusion
The occurrence of CRKP-BSI was significantly increased during the study period. Hematologic malignancies and ICU acquired infection were associated with the development of CRKP BSI. Severe sepsis or septic shock incidents, inadequate empirical antimicrobial therapy and corticosteroids use preceding infection onset caused significant increase of mortality rates in CRKP-BSI patients. High dose carbapenem combination therapy was associated with better outcome.
Tissue Characteristics of Residual Lesion in Patients With Acute Coronary Syndrome Caused by Plaque Rupture Versus Plaque Erosion: A Single-center, Retrospective, Observational Study
Authors: Suzuki Wataru , Ohashi Hirofumi , Ando Hirohiko , Nakano Yusuke , Takashima Hiroaki , Fujimoto Masanobu , Sawada Hiroaki , Goto Reiji , Suzuki Akihiro , Sakurai Shinichiro , Amano Tetsuya
Published: August 2022

PurposePatients with acute coronary syndrome (ACS), frequently caused by plaque rupture (PR), often have vulnerable plaques in residual and culprit lesions. However, whether this occurs in patients with plaque erosion (PE) as well is unknown. Therefore, we compared the tissue characteristics of residual lesions in patients with PE and those with PR.MethodsThe data of 88 patients with ACS who underwent both optimal coherence tomography (OCT) and intravascular ultrasound (IVUS) were retrospectively analyzed. Based on plaque morphology of the culprit lesions identified using OCT, patients were classified into PE and PR groups. The tissue characteristics of residual lesions evaluated using integrated backscatter IVUS were compared between the two groups after percutaneous coronary intervention. ResultsPatients were classified into the PE group (n=23) and PR group (n=35). The PE group had a significantly lower percent lipid volume and a higher percent fibrous volume than those of the PR group (35.0±17.8% vs. 49.2±13.4%, p<0.001; 63.2±17.1% vs. 50.3±13.1%, p=0.002, respectively). Receiver operating characteristic curve analysis revealed that the percent lipid volume in the residual lesions was a significant discriminant factor in estimating the plaque morphology of the culprit lesion (optimal cut-off value, <43.5%; sensitivity and specificity values were 73.9% and 68.6%, respectively).ConclusionsPatients with PE had a significantly lower percent lipid volume and a significantly higher percent fibrous volume in the residual lesions than in those with PR, suggesting that the nature of coronary plaques in patients with PE is different from that in patients with PR.
Gender differences in the impact-factors of adolescent dissociative symptoms: a structural equation model approach
Authors: Cheng Qinglin , Deng Yuanyuan , Zhao Gang , Chen Junfang , Xie Li , Wang Le
Published: August 2022

Background
Few studies have investigated the gender-specific impact of adolescent dissociative symptoms (ADSs) in China. The purpose of this study was to examine gender differences in the impact factors of ADSs in Hangzhou City, China, as well as to investigate further the direct and interactive effects between ADSs and impact factors by constructing a structural equation model (SEM).
Methods
A school-based, two-center cross-sectional study was conducted in Hangzhou City, China. The sample comprised 2,160 adolescents aged 13–18 years who were randomly selected using a multi-phase, stratified, cluster sampling technique. We used a SEM to explore the direct and interactive effects between ADSs and influencing factors by gender stratification.
Results
A total of 1,916 participants were included in the two-center cross-sectional study. The male SEM model showed that the significant standardized paths (P < 0.05) were between psychological factors and environment factors, both positively related to ADSs (psychological factors and environment factors). In addition, a significant correlation was also observed between teacher-student conflict relationship and ADSs. The female SEM model indicated that there were the significant standardized paths between peer interpersonal interaction relationship and psychological factors, in which peer interpersonal interaction relationship was negatively correlated to ADSs, and psychological factors tended to correlate positively with ADSs. We also found that there was a correlation between peer interpersonal interaction relationship and hostility. Our findings indicated that the strongest effect was psychological factors for male (total standardized β = 0.365) or female ADSs (total standardized β = 0.674). The SEM model fit indices indicated that the proposed models fit the data for both male and female ADSs.
Conclusions
Our findings suggested that health resources and strategies could be allocated and performed rationally to enhance their utilization efficiency during ADSs screening and other public health actions. To reduce the risks of adolescent dissociative disorders and other mental disorders, we urgently need to develop gender-specific intervention strategies for ADSs.
Citizen science to determine sea turtles’ spatio-temporal parameters on a subtropical foraging ground
Authors: Neves-Ferreira Isabella , Mello-Fonseca Juliana , Ferreira Carlos Eduardo Leite
Published: August 2022

Sea turtles spend most of their life cycle in foraging grounds. Nevertheless, given the logistical ease, bulk of studies are carried out in nesting grounds. One strategy to gather information in foraging grounds is the use of cost-effective and non-invasive techniques that allow public participation. The present study aimed to use photographic-identification to investigate the spatio-temporal distribution of Chelonia mydas and Eretmochelys imbricata. Furthermore, we describe the occurrence of fibropapillomatosis. This work was carried out at subtropical rocky reefs of the Brazilian coast in Arraial do Cabo (22°57’S, 42°01’W), within a sustainable conservation unit. The images were obtained through social media screening, citizen science and intentional capture. A total of 641 photos (between 2006 and 2021) and 19 diving forms (between November 2019 and March 2020) were obtained. All diving forms presented at least one turtle. The photo-id identified 174 individuals of C. mydas, with 45 resighted individuals. E. imbricata had 32 individuals identified, and 7 individuals resighted. The median interval between the first and last individual sighting was 1.7 years for C. mydas and 2.4 years for E. imbricata. Fibropapillomatosis was only observed in C. mydas, with a prevalence of 13.99% and regression in 2 individuals (10.00%). The results indicated Arraial do Cabo as an important development area for sea turtles with resident individuals showing fidelity for at least 6 years. As the region accumulates anthropogenic impacts, it is critical to propose significant management measures to protect sea turtles from continuous and synergistic impacts, mainly on resident individuals.
Integrating Single-Cell RNA-seq to construct a Neutrophil prognostic model for predicting immune responses in non-small cell lung cancer
Authors: Pang Jianyu , Yu Qian , Chen Yongzhi , Yuan Hongjun , Sheng Miaomiao , Tang Wenru
Published: August 2022

Non-small cell lung cancer (NSCLC) is the most widely distributed tumor in the world, and its immunotherapy is not practical. Neutrophil is one of a tumor's most abundant immune cell groups. This research aimed to investigate the complex communication network in the immune microenvironment (TIME) of NSCLC tumors to clarify the interaction between immune cells and tumors and establish a prognostic risk model that can predict immune response and prognosis of patients by analyzing the characteristics of Neutrophil differentiation. Integrated single-cell RNA sequencing (scRNA-seq) data from NSCLC samples and Bulk RNA-seq were used for analysis. Twenty-eight main cell clusters were identified, and their interactions were clarified. Subsequently, four subsets of Neutrophils with different differentiation states were found, closely related to immune regulation and metabolic pathways. Based on the ratio of four housekeeping genes (ACTB, GAPDH, TFRC, TUBB), six Neutrophil differentiation-related genes (NDRGs) prognostic risk models, including MS4A7, CXCR2, CSRNP1, RETN, CD177, and LUCAT1, were constructed by Elastic Net and Multivariate Cox regression, and patients' total survival time and immunotherapy response were successfully predicted and validated in three large cohorts. Finally, the causes of the worse prognosis of NSCLC caused by six prognostic genes were explored, and the small molecular compounds targeted at the anti-tumor effect of prognostic genes were screened. This study clarifies the TIME regulation network in NSCLC and emphasizes the critical role of NDRGs in predicting the prognosis of patients with NSCLC and their potential response to immunotherapy, thus providing a promising therapeutic target for NSCLC.
Covered Transjugular Intrahepatic Portosystemic Shunt improves survival for variceal Bleeding in cirrhotic patients with hepatic venous pressure gradient≥16 mmHg: A a comparison study
Authors: Wang Xixuan , Yin Xiaochun , Gu Lihong , Guo Huiwen , Cheng Yang , Liu Yan , Xiao Jiangqiang , Wang Yi , Zhang Wei , Zou Xiaoping , Wang Lei , Zhang Ming , Zhuge Yuzheng , Zhang Feng
Published: August 2022

Objectives:TIPS can decrease rebleeding in cirrhotic patients with variceal bleeding (VB), but it is controversial whether TIPS can improve survival. We aimed to assess whether TIPS improves survival in selected patients based on HVPG-related risk stratification in a long-term follow-up.Methods:Consecutive VB patients treated with endoscopic therapy+NSBBs or covered TIPS were retrospectively enrolled between January 2013 and December 2019. All patients had HVPG measurements by experienced personnel before therapy. Outpatient follow-up was performed regularly. The primary outcome was transplant-free survival. The secondary endpoints were rebleeding and OHE. Statistical analysis were performed.Results:According to the inclusion and exclusion criteria, 184 patients were analyzed (Mean age 55.27years ± 13.86, 107 males; 102 endoscopic therapy+NSBBs, 82 covered TIPS). Based on the HVPG-guided risk stratification, 70 patients had HVPGs lower than 16 mmHg, and 114 patients had HVPGs higher than 16 mmHg. The median follow-up time was 49.5 months. In the total cohort, the difference between the 2 therapies in terms of transplant-free survival was not statistically significant in the TIPS group (hazard ratio 0.6092, 95% CI 0.3546-1.046; p=0.0725). In the high-HVPG tier, transplant-free survival was higher in the TIPS group (hazard ratio 0.4385, 95% CI 0.2255-0.8525; p=0.0037). In the low-HVPG tier, transplant-free survival between the 2 treatments was similar without statistical significance (hazard ratio 0.8583, 95% CI 0.3301-0.232; p=0.7399). The difference in OHE between the two treatment groups was not statistically significant (P=0.0850; P=0.4791).Conclusions:TIPS can effectively improve transplant-free survival when HVPG is greater than 16 mmHg.
Achieve structural white inspired from quasi-ordered microstructures in Morpho theseus
Authors: Zhang Wang , Zhao Xinkun , Xiong Yuqin , Wang Wanlin , Zhang Di
Published: August 2022

As one of the most fascinating phenomena, structural whiteness in natural organisms serves as important functions in thermoregulation and mating. However, the architectures that cause the visible broadband reflection are often in quasi-disordered distribution, which hinders the systematic research of the color formation mechanism. Here, through numerical analysis, architectures in Morpho theseus scales are distributed in various tubular morphologies between tubular and gyroid structure. Then the mechanism of the structural white is discussed using the numerical model built with the combination of periodic numerical framework and random elements. Thermodynamic experiments indicate that the white scales can efficiently help reducing the temperature of butterfly wings under direct light beam. Our work provides a concise method to analyze the quasi-ordered structures. The methodology developed by this numerical model can facilitate deep understanding of performance improvement brought by these structural characteristics. Corresponding solutions can guide the design of nano-optical materials to achieve the efficient cooling, camouflage, and photothermal conversion system.
Identification of Coronavirus in Bats and Rodents From Northern and Central Argentina
Authors: Arteaga Franco Lucero , Miragaya Marcelo , Molina Nicolas , Mondino Mariela , Bracamonte Cesar , Capitelli Gabriel , Mundo Silvia , Bratanich Ana Cristina
Published: August 2022

Due to the present pandemic situation and the many animal species epidemiologically involved, a renewed interest has surged to investigate the coronavirus population circulating in wildlife, specially bats and rodents as potential reservoirs of new human pathogens. In Argentina, information about the viruses present in these mammals is very reduced. To investigate the presence of coronaviruses in this country, we obtained 457 samples from hematophagous, insectivorous, and frugivorous bats and rodents from two regions of Argentina. We report here the detection of alphacoronaviruses sequences in the three groups of bats as well as in rodents. Phylogenetic analysis showed the closest relationships to alphacoronaviruses from Brazil.
Molecular docking analysis and anti-apoptotic activity of Hypericum triquetrifolium Turra (St. John's-wort) in Cyclophosphamide-induced lung injury
Authors: Yıldız Songül Çetik , Keskin Cumali , Şahintürk Varol , Gür Bahri , Oğul Yasemin , CENGİZ Mustafa , Ayhanci Adnan
Published: August 2022

The present study aims to investigate the lung-protective and antiapoptotic effects ofHypericum triquetrifolium Turra(HTT) against cyclophosphamide (CP)-induced lung injury in rats. Thirty-five Sprague Dawley rats were categorized into 5 groups, each consisting of seven members. Phenolic acid and flavonoid contents of this plant were determined. The lung tissue samples cultivated from the rats were examined both histopathological and immunohistochemically for the apoptosis markers of Caspase-3, Bax, and Bcl-2. Histopathological results indicated that structural defects, bleeding areas, and edema had occurred in the lungs of the CP-Alone Group. Besides, Caspase-3 and Bax positivity of the lung cells had also increased while Bcl-2 positivity had decreased. On the other hand, in the HTT + CP Group, HTT was shown to have reversed the aforementioned changes positively. In addition, ourin-vivoresults were confirmed by thein-silicostudies. The changes that occurred in the binding of CP to the active-site amino acid residues of Caspase-3, Bax, and Bcl-2 upon the addition of Hyperoside besides the changes that occurred in their tendency to form hydrogen bonds were accounted for byin silicostudies. Based onin vivoandin silicoresults, HTT could be a strong protective candidate for CP-induced lung injury and apoptosis.
On the selection of a proper connection in describing the dynamics of constrained mechanical systems
Authors: Natsiavas Sotirios , Passas P. , Tzaferis K.
Published: August 2022

This study is focused on a critical issue related to the consistent application of Newton’s law of motion to a special but large class of mechanical systems, involving equality motion constraints. For these systems, it is advantageous to employ the general Analytical Dynamics framework, where their motion is represented by a curve on a non-flat configuration manifold. The geometric properties of this manifold, providing the information needed for setting up the equations of motion of the system examined, are fully determined by two mathematical entities. The first of them is the metric tensor, whose components at each point of the manifold are obtained by considering the kinetic energy of the system. The second geometric entity is known as the connection of the manifold. In dynamics, the components of the connection are established by using the set of the motion constraints imposed on the original system and provide the torsion and curvature properties of the manifold. Despite its critical role in the dynamics of constrained systems, the significance of the connection has not been investigated yet at a sufficient level in the current engineering literature. The main objective of the present work is to first provide a systematic way for selecting this geometric entity and then illustrate its role and importance in describing the dynamics of constrained systems.
Serum response factor reduces gene expression noise and confers cell state stability
Authors: Zhang Jian , Hu Xiao , Wu Qiao , Guo Shangqin
Published: August 2022

The role of serum response factor (Srf), a central mediator of actin dynamics and mechanical signaling, in cell identity regulation is debated to be either a cell identity stabilizer or destabilizer. We thus investigated the role of Srf in cell fate stability using mouse pluripotent stem cells, one of the very few cell types that can tolerate null Srf. Despite the fact that serum-containing cultures yield heterogeneous gene expression, deletion of Srf in mouse pluripotent stem cells leads to further exacerbated cell state heterogeneity. The exaggerated heterogeneity is not only detectible as increased lineage priming, but also as the 2C-like cell state. Thus, pluripotent cells explore more variety of cellular states in both directions of development surrounding naïve pluripotency, a behavior that is constrained by Srf. These results support that Srf functions as a cell state stabilizer, providing rationale for its functional perturbation in cell fate engineering and pathological intervention.
Antecedents of organizational commitment and its relationship with turnover intention: A study of business employees in pharmaceutical multi-national companies.
Authors: Can Hoang Nguyen Khanh , Nguyen Xuan Nhi
Published: August 2022

Background The high turnover rate in pharmaceuticals multi-national companies in Vietnam market in recent years has been received attention from not only human resources departments but also other commercial managers. The purpose of this research is to investigate the antecedents affecting organizational commitments and its relationship with turnover intention. Methods This research used a sample of sales and marketing employees (N = 357), both staff and manager roles, in twenty pharmaceuticals multi-national companies in Vietnam market. Mixed methods of qualitative and quantitative are utilized. Results Three of fifteen hypotheses are not supported which results in the fact that the employee voice does not impact on organizational commitment in general. Only two normative commitment and continuance commitment have the negative impacts to turnover intention. The career development and organizational justice have the biggest impact to normative commitment which also has the biggest impact to turnover intention. Conclusions The research results suggest the practical actions increasing the level of career development and organizational justice, in order to increase the level of normative commitment and to reduce the turnover intention. The present research is among the first ones to discover the antecedents affecting organizational commitment and its relationship with turnover intention, especially in the environment of pharmaceuticals multi-national companies in Vietnam.
Enhanced Neomycin antibiotic properties through proteolytic enzyme in Escherichia coli induced infection in broiler chicks
Authors: Uzair Muhammad Shahkar , Mushtaq Muhammad , Shah Muqader , Ullah Haq Aman , Sadique Umer , Khan Hamayun , Anwer Faisal , Ahmad Ijaz , Nawaz Noor-Ul-Ain
Published: August 2022

The study aimed to explore the beneficial aspect of Serratiopeptidase (proteolytic enzyme) combined with low profile antibiotic (Neomycin) in chickens against the E. coli infection at the finisher stage. Both in-vitro and in-vivo studies were carried out to evaluate the antimicrobial activities and potency of this combination. A total of one hundred and eighty (180) day-old chicks were randomly allotted to 6 groups i.e. G1 (negative control), G2 (positive control), G3 (standard antibiotic only), SN-1 (Serratiopeptidase @40g/L+ Neomycin@10mg/L), SN-2 (Serratiopeptidase @50mg/L+ Neomycin @20mg/L), and SN-3 (Serratiopeptidase @ 60mg/L+ Neomycin @30mg/L). Each group consisted of thirty birds with 5 replicate (6 birds/ replicate). On day 21, fresh inocula of E. coli (1x109cfu) were orally administered to all the groups except negative control. The results revealed that birds in SN-3 group showed significantly larger zone of inhibition, increased feed intake, weight gain and improved feed conversion ratio compared to standard and control groups. Moreover, reduced (p<0.05) mortality and morbidity index was found in SN-3 group among all the treated groups. Histopathological study revealed that SN-3 group had improved (p<0.05) tissue health and enhanced regenerative changes were observed. It was concluded, that use of serratiopeptidase combination with Neomycin has better impact on broiler chickens to enhance the antimicrobial effect of Neomycin against E. coli infection and to enhance production parameters.
Involvement of ACACA (acetyl-CoA carboxylase α) in the lung pre-metastatic niche formation in breast cancer by senescence phenotypic conversion in fibroblasts
Authors: Huang Yung-Chi , Hou Ming-Feng , Tsai Ying-Ming , Pan Yi-Chung , Tsai Pei-Hung , Lin Yi-Shiuan , Chang Chao-Yuan , Tsai Eing-Mei , Hsu Ya-Ling
Published: August 2022

BackgroundImpairment of metabolism is strongly associated with the development of cancer. However, the role of metabolic reprogramming in the remodeling of pre-metastatic niche (PMN), a key step in metastasis, is still unknown. We aimed to investigate the metabolic alternation during lung PMN formation.MethodsWe assessed the transcriptomes and lipidomics of lung of MMTV-PyVT mice by microarray and liquid chromatography-tandem mass spectrometry before lung metastasis. The validation of gene or protein expressions was performed by real-time quantitative polymerase chain reaction, immunoblot and immunohistochemistry. The lung fibroblasts were isolated from mice and then co-cultured with breast cancer to identify the influence of cancer on the change of lung fibroblasts in PMN.ResultsWe demonstrated changes in the lipid profile and several lipid metabolism genes in the lungs of breast cancer-bearing MMTV-PyVT mice before cancer spread. The expression of ACACA (acetyl-CoA carboxylase α) was downregulated in the lung fibroblasts, which contributed to changes in acetylation of protein’s lysine residues and the synthesis of fatty acid. The downregulation of ACACA in lung fibroblasts triggered a senescent and inflammatory phenotypic shift of lung fibroblasts in both in vivo and in vitro models. The senescence-associated secretory phenotype of lung fibroblasts enabled the recruitment of immunosuppressive granulocytic myeloid-derived suppressor cells into the lungs through the production of CXCL1 in the lungs. Knock-in of ACACA prevented lung metastasis in the MMTV-PyVT mouse model, further supporting that ACACA was involved in the remodeling of the lung PMN.ConclusionsTaken together, these data revealed a mechanism by which ACACA downregulation directs the formation of an immunosuppressive lung PMN in breast cancer.