bluuebunny/crossref_metadata_2025 huggingface dataset:
Experimental analysis of walking induced vibrations in composite floor and performance evaluation considering human confort
Authors: Silva Júnior Ladir Antônio da , Pinto Jose Francisco Anunciação
Published: December 2022

Abstract NBR 8800 was updated in the year of 2008. Acceptance criteria of vibrations on floor performance considering human comfort were simplified and only minimum values of fundamental frequency are considered for performance evaluation. The objective of this article is to evaluate a methodology of experimental analysis of footfall-induced vibrations in steel and composite system floors and footbridges in order to check the human comfort conditions. The methodology was established according to international standard recommendations and international design guides. In order to present its applicability, it was applied to four case studies. The spectrum processing provided the values of natural frequency, damping ratio and peak acceleration. All the floors presented values of fundamental frequency greater than the minimum values recommended by NBR 8800. However, the obtained peak acceleration for some cases presented values greater than the maximum value recommended by international criteria. Therefore, the simplified acceptance criteria proposed by NBR 8800 were insufficient for performance assessment of some system floors and footbridges.
EFFECT OF SURGICAL TREATMENT OF SCOLIOTIC CURVATURE ON THE SPINE AND UPPER LIMBS
Authors: Santos Henrique Alexandre Miranda , Barsotti Carlos Eduardo Gonçalves , B Junior Carlos Augusto Belchior , Andrade Rodrigo Mantelatto , Torini Alexandre Penna , Ribeiro Ana Paula
Published: December 2022

ABSTRACT Objectives: Evaluate the surgical treatment of scoliotic curvature effects and sagittal radiographic parameters of the spine and upper limbs after surgical treatment with direct vertebral rotation (DVR) associated with type 1 osteotomy in adolescents with idiopathic scoliosis (AIS). Material and Methods: 41 patients with AIS were evaluated and compared before and after surgery. Scoliosis was confirmed by a radiographic of the spine. The radiographic parameters evaluated were: Cobb angles (proximal and distal thoracic), segmental kyphosis (T5-T12), total kyphosis (T1-T12), cervical lordosis (C2-C7), distance from the center of gravity of the skull to C7 (Cervical VAS), measurement of T1 slope (T1), neck slope, IT slope (AP), angle of the upper chest opening and plumb line C7-S1 (SVA C7-S1). Statistical analysis compared the pre- and post-surgical effects of sagittal cervical and shoulder parameters. Results: After the surgical procedure, significant reductions were observed for the following parameters of spine measurement: proximal and distal thoracic Cobb angle, with a correction of 68% of the main thoracic curve. The measurements of the inclination of the T1 profile and the inclination of the neck also improve after surgery. Regarding the shoulders, there was a reduction in T1 AP slope and intercoracoid angle after surgery. The other radiographic parameters did not show significant differences. Conclusion: Surgical treatment with direct vertebral rotation (DVR) associated with type 1 osteotomy promoted better sagittal radiographic parameters of the thoracic Cobb angles, T1 inclination of the cervical spine, neck inclination, and better shoulder symmetry. Level of Evidence II; Prospective study.
Reduction of the environmental impacts of reinforced concrete columns by increasing the compressive strength: a life cycle approach
Authors: Bacelar Bruno Athaíde , Dias Thalita Cardoso , Ludvig Péter
Published: December 2022

Abstract The building industry is one of the greatest environmental impact causers in the planet. Cement is the second most used material in the world and the consumption of concrete ranges between 20 to 30 Gt yearly. This demand for the materials ten ds to increase for the next 100 years. The increase of concrete strength to reduce the material consumption is one of the options proposed in literature to reduce the environmental impacts in building industry. However, few studies have been carried about the actual advantages of this strategy in building production. In this paper, a 15-storey reinforced concrete building was designed with three different concrete grades for its columns: 30 MPa, 40 MPa and 50 MPa. The results for the volume of concrete and the amount of reinforcing steel to produce the columns were used to perform a cradle-to-gate life cycle assessment (LCA) to determine the alternative with less environmental impacts in the production stage. Results indicate an advantage to adopt higher strength concretes in columns to reduce environmental impacts and the consumption of materials. Direct effects of higher strength in concretes made possible to reduce the consumption of concrete by 15%. There was also a significant reduction caused by indirect effects of higher strengths in concrete, with the reducing of steel consumption up to 22%. With the combination of the direct and indirect effects of higher compressive strengths, it was possible to reduce the environmental impacts of reinforced concrete in all categories studied in the LCA.
Compressibility, permeability and microstructure of fine-grained soils containing diatom microfossils
Authors: Zhang Xianwei , Liu Xinyu , Xu Yiqing , Wang Gang , Ren Yubin
Published: December 2022

Fine-grained soils containing diatom microfossils of biological origin are found worldwide. However, although these soils are acknowledged to have unique physical and mechanical properties, the exact role of diatoms in determining their compression and hydraulic behaviours remains unclear, especially when high effective stress is involved, and the underlying micromechanism is yet to be revealed. This study investigated the compression and permeability of diatomaceous soils prepared by mixing pure diatom and kaolin powders through one-dimensional constant rate of strain compression tests with a maximum vertical stress of 10 MPa. The microstructure of the soils studied was observed by atomic force microscopy, scanning electron microscopy and mercury intrusion porosimetry, and the microstructural evolution during compression was traced. The results indicate that the special hollow structure of diatom particles with internal pores contributes significantly to the high void ratio, compressibility and permeability of diatomaceous soils, and increasing the diatom content improves the pore distribution non-uniformity of the diatom–kaolin mixtures. In addition, the diatom particles have high brittleness and breakage potential, leading to microstructural rearrangement during compression, especially pore-structure adjustment. Lower compressive stress deforms the inter- and intra-aggregate pores, but higher vertical stress damages the diatoms’ hollow structure, which changes the compression and hydraulic parameters in a different manner from the case of conventional clay. This paper enriches the knowledge concerning the multilevel behaviour of fine-grained soils containing diatom microfossils and provides a fundamental dataset.
Editorial: Education research in Wales, from Wales, and for Wales
Authors: Beauchamp Gary , Thomas Enlli , Crick Tom
Published: December 2022

Editorial - Wales Journal of Education 24.2
Making Better Informed, More Confident COVID-19 Decisions: Vaccine Hesitancy, Its Barriers and Impact Studies: Taking Bayelsa State as an Example
Authors: OM Raimi , EC Lucky , E Okoyen , A Clement , C Ogbointuwei , A Babatunde
Published: December 2022

Background: Health care practitioners are recognized to have a large influence in shaping uptake of vaccine in new borns, children, adolescents, as well as adults. Parents remain more secure in their decisions when health care practitioners communicate successfully with them about vaccine dangers and benefits, the value as well as necessity for vaccinations, as well as vaccine safety. Thus, immunization remain the foundation of the primary health care system, an indisputable human right as well as a global health and development success story, saving millions of lives yearly. Recently, we have vaccines to prevent more than 20 life threatening diseases, helping people of all ages live longer, healthier lives. Yet despite tremendous progress, far too many people around the world, including nearly 20 million infants yearly have insufficient access to vaccines. In some countries, progress has stalled or even reversed, and there is a real risk that complacency will undermine past achievements. Purpose: The current study aimed to explores vaccine hesitancy, its barriers and impact studies regarding COVID-19 decision impacts. Also, to provides policy and decision makers and operational staff with evidence to inform decisions to promote vaccine uptake across Bayelsa State. Methods: A literature review tried to do a deep dive by using a variety of search engines such as Scopus, Research Gate, Mendeley, Summon, PubMed, Google Scholar, Hinari, Dimension, Academia, CAB Abstract, OARE Abstract, SSRN search strategy to retrieve research publications, “grey literature” and expert working group reports, including author’s field experience. Findings: Absence of uniform methods of organization in the various health care facilities upon which we were obliged to rely. Thus affecting the overall immunization programme and health system. Hence policy must urgently address these challenges with emphasis on policy clarity while continuously improving infrastructure. Conclusions: Bayelsa State is categorized as low/poor performing as the findings suggest that the involvement of community based leaders can improve community participation and acceptance, while enhancing and strengthening integrated disease surveillance and Adverse Events Following Immunization (AEFI) monitoring and reporting systems; and conducting integrated advocacy and communications activities to promote demand for vaccination as part of increasing overall demand and acceptability of all essential Primary Health Centers (PHC) services, thus, breaking barriers of vaccine hesitancy.
Die Wirtschaft in STAR TREK. Eine populärkulturelle Verarbeitung von Karl Marx’ Vision eines »Reichs der Freiheit«?
Authors: Kremser Christian E. W.
Published: December 2022

The article takes the claim that the economy of the Federation in Star Trek represents a pop-cultural reception of Karl Marx’s higher phase of communism as its starting point. This assertion will be put to test. In order to do this, Marx’s thoughts about the higher phase of communism as well as descriptions of Star Trek’s economy will be summarized as a first step. Since both the higher phase of communism and the Federation’s economy describe an economic state in which the basic material needs are met, they can both be conceived as material utopias. This is the common ground that explains why it makes sense to draw parallels between Marx and Star Trek. Subsequently, a typology of material utopias is presented. The central distinguishing feature between different kinds of material utopias is the recommended strategy to establish a state of frugality. Here, a striking difference becomes apparent: According to Marx, the higher phase of communism, depends on unleashing the productive forces, while Star Trek focuses on changing the people’s minds regarding economic matters. Therefore, Marx’s higher phase of communism should be regarded as a technical utopia, whereas the economy of the Federation is best considered to be an ethical utopia.Die
The Accumulation of Some Heavy Metals in Northern Pike (Esox lucius L., 1758) Inhabiting Sıdıklı Küçükboğaz Dam Lake (KIRŞEHİR)
Authors: PALABIYIK Esra , YILMAZ Mahmut , ER ÇALIŞKAN Çiğdem , ÇİFTÇİ Harun , PALABIYIK Ahmet Alperen
Published: December 2022

Pike (Esox lucius) samples were obtained from the designated locations of Sıdıklı Küçükboğaz Dam Lake between March 2012 and February 2013. Some heavy metal concentrations (Cu, Fe, Mn, Zn, Cr and Al) in the muscle, liver, skin, intestine and gills of this fish were measured by Flame Atomic Absorption Spectrometry (AAS) device and it was observed that heavy metals accumulated at different levels in different tissues of pike. Heavy metal concentration in different fish tissues varied as dry weight Cu: 0.1123-0.3764, Fe: 4.3135-9.505, Mn: 0.5442-0.1684, Zn: 3.3065-2.475, Cr: 0.1889-2.517, Al: 2.17-1.045 µg g-1. When the heavy metal levels in the tissues were compared with the national and international permissible limits, it was seen that the values of all metals in the muscles of the fish were below the determined limit values according to the analysis results. Seasonal changes in metal (Cu, Fe, Mn, Zn, Cr and Al) concentrations were observed in pike tissues, but it was concluded that these differences would not negatively affect the consumption recommendations based on the levels permitted by FAO/WHO (2020). According to the analysis, it was concluded that the fish collected from this region can be safely consumed by humans and the lake water can be used for irrigation purposes in agriculture.
Evaluation of the cookies formulated with finger millet plant material for antidiabetic property
Authors: Amit Semwal , Shilpa Sharma , Sarswati Prakash Bhatt , Mamta Bisht , Rohit Kumar Trivedi , Vikash Jakhmola
Published: December 2022

Cookies are the most popular bakery food consumed worldwide. The development of reduced-sugar soft cookies by using Finger Millet, Syzygium cumini L. (Jamun) and stevia extract was investigated. In addition to it, Buttermilk powder was used as a bulking agent to improve the flavor, color and texture of the cookies along with other ingredients like flour, margarine, salt, sodium bicarbonate, and water. The creamery method of production was used for cookie preparation. Amounts of water, stevia, and buttermilk powder and baking duration for each formulation were determined by preliminary experiments. Different formulations use different ratios to find out the best composition for cookies on the basis of palatability. After the selection of the best composition, cookies were prepared for the physiochemical, sensory and nutritional analysis. Sensory analysis was evaluated based on organoleptic properties: color, taste, aroma and overall acceptability on the basis of a 9-point hedonic scale. The physiochemical evaluation included total ash value, total water, and alcoholic extraction, and total moisture content. On the basis of nutritional value comparison, it was found that protein content is higher in our formulation than in other marketed products. Due to the high antioxidant potential and phenolic content of the Finger Millet cookie, it can be used as a therapeutic or functional food source for the treatment of overweight, obesity, and diabetes.
Artificial seawater medium v1
Authors: not provided Shaaijer
Published: December 2022

This artificial seawater medium was adapted from the Synthetic Crenarchaeota Medium described in Könneke et al. 2005 (10.1038/nature03911).
Preparation of mollusc larval shells for individual geochemical analysis v1
Authors: Mouchi Vincent
Published: December 2022

This protocol describes the digestion process of mollusc larvae and is modified from the procedure found in Becker et al. (2005). Here, we indicate the entire process to obtain the digestion solution, as well as cleaning glassware, actual larval digestion and extraction of shells until storage for subsequent geochemical analysis or observation. This protocol is applicable to shelly larvae of any species, once they are collected and brought to the laboratory. The goal of this preparation is to isolate each larval shell to perform individual geochemical analyses, instead of dissolving several specimens for bulk analysis. To do this, great care needs to be taken to the handling of the shells using ultra-pure solutions and acid-washed glassware to avoid chemical contamination of all kind. Reference: Becker, B.J., Fodrie, F.J., McMillan, P.A., Levin, L.A., 2005. Spatial and temporal variation in trace elemental fingerprints of mytilid mussel shells: a precursor to invertebrate larval tracking. Limnology and Oceanography, 50, 48-61. doi: 10.4319/lo.2005.50.1.0048.
Cost-efficient Yeast genome Flongle library v1
Authors: Hori Yutaro
Published: December 2022

A cost-efficient protocol for constructing a Flongle library.
EXAMINATION OF AGRO-PHYSIOLOGICAL TRAITS OF DIFFERENT CULTIVARS OF MAIZE (Zea Mays) WITH LEAF AND EAR TOPPING
Authors: HOJATIPOUR Eshagh , MIRI Hamid Reza , JAFARI HAGHIGHI Barmak , EBRAHIMI Hamid Reza , JAFARI Abdolreza
Published: December 2022

The biochemical traits of different maize varieties under leaf and cob defoliation conditions were investigated in a factorial experiment, a randomized complete block design with three replications during two crop years of 2017-18 and 2018-19. Treatments consisted of removing leaves and a part of the cob at three levels of control, removing half of the cob after pollination, and removing two upper and lower leaves of the cob after pollination as the first factor. The second factor comprised seven maize varieties including SC704, Kansor, Kordona, Karaj 703, Koosha, Fajr, and Danial 690. After preparing the substrate in the first and second years, seeds of different varieties were planted in the plots based on the treatments. Leaf and cob defoliation treatments were applied after pollination. The results showed that the highest contents of chlorophyll a (98.46 mg/g fresh weight, FW), chlorophyll b (138.7 mg/g FW), carotenoids (74.33 mg/g FW), and anthocyanin (1.915 mg/g FW) were obtained in the SC704 variety under combined treatment of defoliating two upper and lower leaves of the cob. The highest amount of catalase (58.73 mg protein/min) was recorded in Fajr variety in the control, but peroxidase (173.4 mg protein/min) and polyphenol oxidase (64.7 mg protein/min) activities were uppermost in the Koosha variety of the control treatment.
Analysis of the Digital System Simulation Levels for its Design Debugging
Authors:   Institute for Design Problems in Microelectronics of Russian Academy of Sciences, Moscow, Russian Federation, Ivannikov A. D.
Published: December 2022

A brief analysis of the digital system design debugging is given, typical errors and inaccuracies of digital system designs at the development stage are listed. The levels of digital system design simulation are considered: simulation models at the level of queuing; register transfer level models; architecture and microarchitecture level models; quasi-timing logic diagram level models; models taking into account the spread of block delays. For each level of simulation, estimates of complexity and time costs are given, as well as the types of detected design errors.
Simulating Complex for Debugging Algorithms of Autonomous Underwater Robots
Authors:   Institute of Automation and Control Processes of the Far Eastern Branch of the Russian Academy of Sciences, Vladivostok, Russian Federation, Bobkov V. A. , May V. P. ,   Institute of Automation and Control Processes of the Far Eastern Branch of the Russian Academy of Sciences, Vladivostok, Russian Federation
Published: December 2022

The program simulating complex for debugging of developing systems and control algorithms of autonomous underwater robots (AUR) is considered. The complex allow to simulation wide spectrum of modeling data, tune up developing algorithms and operate as simulator directly in the AUR control system environment. Into its structure enter model of movement, copy of AUR control system environment with wide spectrum of modeling data, the editors of basic complex elements processes and events.
Interaction of temperature fields in soil massif during abstraction of low-grade heat by U-shaped probes of geothermal heat pump units
Authors:   Yuri Gagarin State Technical University of Saratov, Saponenko D.S. , Kuleshov O.Y. ,   Yuri Gagarin State Technical University of Saratov
Published: December 2022

Research in the field of alternative energy sources use is of relevance due to the limited reserves of fossil fuels, the constant cost increase and flue gas emissions generated by power plants along with fuel combustion. The use of low-grade ground energy with the help of geothermal heat pump stations makes it possible to save fossil fuel and reduce environmental pollution. Since about 50 % of the one-time capital investment is spent on the construction of ground loop, the issues on improving the efficiency of ground heat abstraction are of particular relevance. However, until now there is no unified normative technique to calculate ground probes and to create ground loops of optimal constructions. The absence of calculation methods and intelligible practical dependencies does not allow one to quantify the influence of various factors on the heat extraction process, the intensity of which varies significantly over time. The authors have applied two analytical methods in the developed mathematical model. The first one is a source-sink method adapted to the non-stationary process of heat abstraction away from the soil mass. And the second one is the superposition method which made it possible to quantify the effect of the interaction of temperature fields in the well. The mathematical model has been developed, and calculated dependences have been obtained. The authors have presented a calculation method and the results of mathematical modeling of the non-stationary process of soil heat abstraction by a vertical U-shaped geothermal probe and the internal interaction of the temperature fields of the downcomer and riser pipes. The results of the computational experiment are presented in the form of graphs. The authors have determined three key particular cases of the operation of a ground probe and formulas to define the maximum allowable increment of the temperature of the heated coolant under the condition of maximum efficient use of the heat-receiving surface applicable to various types of soil. The analysis of the obtained results makes it possible to identify the main factors affecting the heat-absorption efficiency (actual heat transfer coefficients and specific heat inflows) for each of the pipes and for the entire probe, considering the interaction of temperature fields around the downcomer and riser pipes during the heating period.
Development of thermal insulation with ordered structure based on Neovius TPMS
Authors:   Samara State Technical University, Popov A.I.
Published: December 2022

Currently, materials with a random pore arrangement are mainly used as thermal insulation. Such materials, as a rule, have low strength. To solve a number of structural tasks, a heat-insulating material with a high specific strength is required.To date, for these purposes sandwich panels with layers of honeycomb cells filled with air are applied. In this regard, the current goal is to develop more efficient materials with an ordered structure, which will have greater thermal resistance and strength. For numerical simulation of thermal conductivity in a porous material with an ordered structure, the Steady-State Thermal module of the ANSYS software package has been used. Polymers that are often used in 3D printing, such as PETG plastic and Phrozen photopolymer, are chosen as materials for a porous medium with the Neovius TFMT structure. As a result of the study of thermal conductivity in an elementary cell of the Neovius surface in the ANSYS software package, the values of the effective thermal conductivity coefficient are obtained for various characteristic of geometric parameters (cell wall thickness, length of the edge of the cube in which the cell of the Neovius surface is inscribed). Based on the results obtained, it has been found that the dependence of the coefficient of effective thermal conductivity on the cell wall thickness (as well as on the relative cell thickness) is linear. It has been also determined that the geometry under study has a quasi-isotropic thermal conductivity, since it has cubic symmetry. Based on these results, the corresponding graphical and analytical dependencies are designed. The developed heat-insulating material with an ordered structure based on Neovius TPMT is proposed to be used as thermal insulation. The obtained graphical and analytical dependences make it possible to determine the coefficient of effective thermal conductivity of a material with a structure based on the Neovius TFMT with known characteristic geometric parameters (cell wall thickness, cube edge length). The results obtained can be used to design thermal insulation for several tasks when, in addition to thermal insulation properties, structural strength is also important. The porous structure can be produced using modern 3D printing methods, such as selective laser sintering (SLS), laser stereolithography (SLA), etc.
The First Edition of “The Justification of Good” (1897): Contemporaries’ Response. Part 2
Authors:   Lomonosov Moscow State University, Mezhuev B.V.
Published: December 2022

The article continues the systematic review and analysis of newspaper and magazine responses to the first edition of V. Solovyov’s main work on moral philosophy “Justification of good” (1897). In the second part of the article we are talking about the scandal associated with a sharp response to the book of V. Solovyov on the pages of the “Novoye Vremya” regular columnist of the newspaper F.E. Shperk having questioned the necessity of moral philosophy and argued that good does not require any justification, and it is impossible to justify any system of morality with reasonable arguments. The article claims that Shperk's attack caused a big scandal in circles close to V. Solovyov. The reaction to this controversy from publications sympathetic to V. Solovyov is also described. It is noted that the publisher of the newspaper “Novoye Vremya” A.S. Suvorin himself had to politely dissociate himself from the speech of his columnist. The article also reveals the reasons that prompted Shperk to soften his position and his formulations. The article provides a new document - an unpublished letter from V. Solovyov to Suvorin, making why the philosopher’s public reaction to this particular response clear. In conclusion, it is proved that the incident led to a serious mutual alienation Vl. Solovyov from V.V. Rozanov, whom the philosopher reasonably suspected of involvement in this publication.
Yevgeny A. Boratynsky’s Philosophical Lyrics in the Perception of Vasily V. Zenkovsky and Semyon L. Frank
Authors:   Gorky Institute of World Literature, Russian Academy of Sciences, Anokhina Yu.Yu.
Published: December 2022

A particular aspect of the problem of interference of philosophy and literature is considered. This article reflects the results of the ongoing study of the problem of perception of poetry by E.A. Boratynsky in Russian philosophical thought. For the first time, an analysis of the reception of Baratynsky's lyrics in the works of Archpriest V.V. Zenkovsky and S.L. Frank is presented. The novelty of the study is seen in the fact that the stated problem is considered for the first time. The relevance seems to lie in the interdisciplinary nature of the research being undertaken. Appeal to the method of slow reading allows us to reconstruct two specific examples of the complex process of interaction between Russian literature and philosophy. Particular attention is paid to Zenkovsky's article “Philosophical Motives of Russian Poetry”, as well as Frank's abstracts “The Meaning of Suffering”, “On the Meaning of Suffering in Russian Literature” and his “Etudes on Pushkin”. It is shown that both Zenkovsky and Frank saw in Boratynsky, first of all, a contemporary of A.S. Pushkin, a poet-philosopher who expressed pessimistic ideas in his work. At the same time, unlike Zenkovsky, who tried to define the essence of Boratynsky's lyrics as such, Frank turned to the poet's poems in order to determine the place of Pushkin in Russian poetry and, on the other hand, in order to express the provisions of his own concept of suffering more clearly.
Giant perianal seborrheic keratosis as a manifestation of the Leser-Trelat syndrome
Authors: Rasulov A. O. , Kulikov A. E. , Madyarov J. M. , Rasulov Z. R. , Shestakova L. A. , Zhukov A. G. , Lvova Yu. E. , Rasulov R. A.
Published: December 2022

Seborrheic keratosis is the most common benign tumor of the epidermis. Rarely the tumor develops in the perineal area and quite rarely is large. For the Leser-Trelat syndrome these tumors is a marker of a malignant disease even before the symptoms are appeared, as well as a manifestation of the paraneoplastic process. In our case report, a giant perianal seborrheic keratoma was the reason for the clinical examination of the patient and stomach cancer was detected. As a result, we demonstrated a successful experience of surgical treatment of seborrheic keratoma of the perianal area and determined an algorithm for the treatment of stomach cancer.
Primary cutaneous diffuse large B-cell lymphoma, leg type, in an 80-year-old female patient. Clinical case
Authors: Ryabukhina Yu. E. , Abbasbeyli F. M. , Timofeeva O. L. , Zeynalova P. A. , Zhukov A. G.
Published: December 2022

Primary cutaneous diffuse large B-cell lymphoma, leg type, is diagnosed in 20-25 % cases of all primary cutaneous B-cell lymphomas, primarily in elderly women (older than 70 years). The disease has aggressive recurrent progression and worse prognosis than other variants. The standard antitumor drug therapy are such regimens as R-CHOP and CHOP-like programs including anthracycline antibiotics. Use of these programs can be limited by the presence of cardiovascular and other concomitant disorders.

Due to the limited variety of combinations of antitumor agents, low frequency of diagnosis of this immunomorphological variant of lymphoproliferative disease and absence of a single algorithm of drug therapy, every clinical case is interesting and informative.

In the presented clinical case, an 80-year-old female patient with primary cutaneous diffuse large B-cell lymphoma, leg type, and concomitant pathology of the cardiovascular system underwent 2 courses of R-CVP regimen drug therapy without anthracyclines. A significant antitumor clinical effect was achieved in the form of complete tumor regression. Treatment was not accompanied by significant toxicity which allowed to complete therapy.
Use of transoral ultrasonography technique in tongue cancer: Advantages and disadvantages
Authors: Allakhverdieva G. F. , Mudunov A. M. , Batsev A. F.
Published: December 2022

Aim. To evaluate advantages and disadvantages of transoral ultrasonography (US) in tongue cancer.

Materials and methods. US was performed in 165 patients between the ages of 15 and 85 years with malignant tumors of the mobile tongue (74 (44.9 %) women, 91 (55.1 %) men).

Among 165 patients, 144 had primary tongue tumor. The study also included 21 (12.7 %) patients with recurrent tumor which clinically could be represented by a true recurrence (tumor development 6 months after the end of treatment) or by continued growth (tumor development less than 6 months after the end of treatment). The study included patients with tongue tumors Т1 - 50 (30.3 %) patients, Т2 - 78 (47.3 %) patients, Т3 - 16.4 % of patients, Т4 - 6.1 % of patients.

Three types of approach to tongue tumor visualization were used: submandibular, transoral, and transbuccal with a standard linear transducer (4-9 MHz) and intraoperative linear transducer (5-14 MHz). In total in 165 patients with tongue tumors, 147 (89.1 %) transoral US, 86 (52.1 %) submandibular US and 25 (15.2 %) transbuccal US examinations were performed.

Results. Among 165 patients, agreement between the sizes measured using US and histological examination was observed in 142 (86.1 %) patients taking into account 15 % error.

With increasing tumor thickness and, correspondingly, T criterion, increased frequency of agreement between US data and histological data was observed. Thus, for T1 stage frequency of agreement with US data was observed in 61.8 % of cases, for Т2 stage in 81.1 % of cases, for Т3 stage in 93.8 %, and for Т4 stage agreement was observed in 100 % of cases.

Frequency of agreement with histological data in evaluation of tongue tumor thickness for transoral approach was significantly higher than for submandibular approach (р = 0.014). Transoral technique was more accurate for measurement of thickness of primary tumors - 80.3 % of results agreed with histological examination, and for recurrences frequency of agreement was only 33.3 %. Submandibular approach for primary tumors showed accurate measurements only in 67.6 % of cases, in recurrent tumors in 58.3 % of cases. Transbuccal approach also showed higher measurement accuracy for tumor thickness in primary patients (70.0 %) compared to recurrent tumors (40.0 %).

Conclusion. Use of transoral ultrasonography significantly improves clinical staging of tongue tumors at the preoperative stage.
A case of combination treatment of femoral osteosarcoma
Authors: Filimonov A. A. , Kutakov N. M. , Chekini D. A. , Musaev E. M. , Akhov A. O. , Zhukov A. G. , Timofeeva O. L. , Abbasbeyli F. M. , Ryabukhina Yu. E. , Zeynalova P. A. , Fedenko A. A. , Ibragimov E. K.
Published: December 2022

Osteosarcomas are rare tumors with aggressive biology. It is important to refer such patients to a high-volume center, where an accurate diagnosis and optimal treatment are more likely to be performed. In contrast to Ewing's sarcoma, conventional osteosarcomas are believed to be generally resistant to radiation therapy, and the main treatment modalities are surgery and chemotherapy. In this clinical case, we demonstrate the efficacy of combined treatment of osteosarcoma of the femur.

Preoperative chemotherapy allowed to evaluate tumor sensitivity to systemic treatment in vivo and optimize adjuvant treatment after R0 resection which allowed to achieve complete clinical response to treatment.
A Novel Hybrid Spotted Hyena-Swarm Optimization (HS-FFO) Framework for Effective Feature Selection in IOT Based Cloud Security Data
Authors: Lohitha N. Sai , Pounambal M.
Published: December 2022

Internet of Things (IoT) has gained its major insight in terms of its deployment and applications. Since IoT exhibits more heterogeneous characteristics in transmitting the real time application data, these data are vulnerable to many security threats. To safeguard the data, machine and deep learning based security systems has been proposed. But this system suffers the computational burden that impedes threat detection capability. Hence the feature selection plays an important role in designing the complexity aware IoT systems to defend the security attacks in the system. This paper propose the novel ensemble of spotted hyena with firefly algorithm to choose the best features and minimise the redundant data features that can boost the detection system's computational effectiveness.  Firstly, an effective firefly optimized feature correlation method is developed.  Then, in order to enhance the exploration and search path, operators of fireflies are combined with Spotted Hyena to assist the swarms in leaving the regionally best solutions. The experimentation has been carried out using the different IoT cloud security datasets such as NSL-KDD-99 , UNSW and CIDCC -001 datasets and contrasted with ten cutting-edge feature extraction techniques, like PSO (particle swarm optimization), BAT, Firefly, ACO(Ant Colony Optimization), Improved PSO, CAT, RAT, Spotted Hyena, SHO and  BOC(Bee-Colony Optimization) algorithms. Results demonstrates the proposed hybrid model has achieved the better feature selection mechanism with less convergence  time and aids better for intelligent threat detection system with the high performance of detection.
Recent Developments in Community-Based Mental Health Care in Japan: A Narrative Review
Authors: Iwatani Jun , Ito Junichiro , Taguchi Yukiko , Akiyama Tsuyoshi
Published: December 2022

BACKGROUND: Since the 1950s, mental health care in Japan has been hospital-centered. A set of legislative initiatives were undertaken in 1995, emphasizing the importance of community-based mental health care. However, despite these attempts to develop a community-based mental health care system, the rate of inpatient-based treatment has remained high and the shift from hospital-centered care to community-based has still not fully materialized.
AIM: This study aims to conduct a review of the available literature on the development of community-based mental health care in Japan between 2010 and 2020.
METHODS: We conducted a standardized literature search in the electronic database Igaku Chuo Zasshi, aiming to identify original studies published between 2010 and 2020 that explored community mental health care in Japan. The included studies outcomes were categorized as performance surveys, service user reports, service provider reports, and educational activities. A descriptive-analytical method was implemented in the current review.
RESULTS: A total of 25 studies were examined. Six studies reported surveys assessing the performance of community-based mental health care on the assertive community treatment (ACT), compulsory treatment, home-visit nursing care, physical complications, and a welfare medicine collaboration on a remote islands. Four studies investigated the perspectives of service users or their families on home-visit nursing care, social participation, community program, and legislative revision. Ten studies focused on social withdrawal, service providers perspectives on local population needs, supporting skills, care programs, and the professional growth of psychiatric social workers. Five studies focused on educational approaches for future healthcare professionals and efforts to improve mental health literacy among adolescents.
CONCLUSION: This paper provided the first comprehensive review of Japans community-based mental health care. Between 2010 and 2020, community mental health care in Japan evolved in many directions, with the understanding that various needs should be met. Home-visit nursing care and ACT can be considered as the most thoroughly investigated and better developed. Research that adopt rigorous methodologies such as randomized controlled trials is required if the goal is to achieve solid conclusions.
The Experience of the Crisis Clinic at the Scientific and Practical Center for Mental Health of Children and Adolescents named after G.E. Sukhareva
Authors: Bezmenov Pyotr V. , Basova Anna Ya. , Deych Roman V. , Severina Yulia V.
Published: December 2022

BACKGROUND: Suicidal behavior by children and adolescents has been and remains one of the most intractable of our social ills. Despite the general downward trend in suicide rates, children and adolescents remain one of the most at-risk groups. Suicidal behavior in all its manifestations is a biopsychosocial problem in which the superiority of one approach or the other cannot be unambiguously justified. It flows from this that strategies that aim to prevent suicide should weave together not just the medical and psychological aspects of the issue, but the social, legal, pedagogical, and other dimensions as well.
AIM: To develop an integrated approach that could provide primary, secondary, and tertiary prevention of suicidal behavior in children, provide the routing of patients, and coordinate actions both between the outpatient link and inpatient specialized care and between different departments, primarily between the Moscow Department of Healthcare and the Department of Education.
METHODS: We analyzed the dynamics of the number of admissions to the Scientific and Practical Center for Mental Health of Children and Adolescents named after G.E. Sukhareva of Moscow Health Department (Sukhareva Center) with suicidal manifestations in 20192022. Organization of the Crisis Care Clinic (Crisis Clinic), which specializes in helping children and adolescents aged 11 to 17 who find themselves in a situation of psychological crisis, have suicidal tendencies, display self-injurious behavior, experience grief, violence, or have suffered abuse.
RESULTS: A comprehensive multi-disciplinary approach is identified as the most efficient way to treat and prevent suicidal behavior in children and adolescents. Psychopharmacotherapy is used to influence severe depressive symptomatology, reduce anxiety, moderate sedation, correct behavioral disorders, etc. In addition to medication, comprehensive psychotherapeutic assistance is recommended. The leading therapeutic approaches are cognitive-behavioral, including DBT, and family therapy, with the efforts of therapists concentrated on alleviating post-traumatic stress, depression, and behavioral problems, as well as resolving intrafamily conflicts.
CONCLUSION: The need to remedy severe crisis conditions and their associated psychopathological repercussions (including suicidal and self-harming behavior) calls for coordinated efforts on the part of specialists from different fields of knowledge related to childhood and adolescence. Our analysis of the experience of working with children and adolescents in the Crisis Clinic at the Sukhareva Center shows that there is high demand for such highly specialized institutions and that the basic principles laid down at its creation, urgency, stage, and continuity of care, poly-professionalism with a focus on non-drug treatment methods, orientation towards the patients family are relevant.
Klebsiella–Candida arthritis model in Wistar rats
Authors: Danilova Elena I. , Fisenko Andrey P. , Stadnikov Aleksandr A. , Perunova Natalya B. , Ivanova Elena V. , Chaynikova Irina N. , Chelpachenko Olga E.
Published: December 2022

MATERIAL AND METHODS: This study was carried out on 20 male Wistar rats, of which 15 were injected with a bacterialfungal suspension into the cavity of the hock (tarsus) joint. Specifically, the rats were injected with KlebsiellaCandida suspension (1:1) with a microbial concentration of 106 CFU/ml prepared by using the museum strains Klebsiella pneumoniae ICIS-278 and Candida albicans ATCC 24433 under the control of an X-ray apparatus and digitizer FireCR+. Five intact animals served as the control. On day 15 of the experiment, a bacteriological and histological examination of the affected joints was carried out while maintaining topography after euthanasia.
RESULTS: In rats infected with the KlebsiellaCandidiasis suspension, pain syndrome and functional changes typical of arthritis were noted on days 23. The bacteriological examination of the affected joints in 75% of rats isolated K. pneumonia cultures that were identical, according to polymerase chain reaction, to the original strain that was part of the bacterialfungal suspension. At the same time, fungi of the genus Candida, which was also used in the experiment to infect animals, were not detected in the affected joints of rats. The established model of KlebsiellaCandida arthritis was characterized by the pathomorphological signs of panarthritis accompanied by the purulent inflammation of all joint structures (synovial membrane, cartilage, and bone tissue) with the involvement of soft periarticular tissues.
CONCLUSION: The model of Klebsiella and fungal arthritis presented by this work can be used to test new means of antimicrobial (antibacterial and antifungal) therapies, which are an integral component of the treatment of infection-associated arthritis.
RANKING OF CROATIAN CITIES ACCORDING TO HELLWIG'S INFORMATION CAPACITY METHOD IN THE SMART ECONOMY DIMENSION
Authors:   University of Rijeka, Faculty of Business and Economics, Babić Ana , Jardas Antonić Jelena , Buljat Barbara
Published: December 2022

The main objective of this research is to determine whether the size of the city by population is a prerequisite for better economic development and ranking of Croatian cities based on the weighted average z-score of smart economy indicators related to entrepreneurial potential, tourism, information comunication technology [ICT] and research and development [R&D] sector. The sample for this research consists of 127 Croatian cities and ten smart economy indicators. The Hellwig's information capacity method uses only statistically significant indicators, on the basis of which the weights are determined when creating the Smart Economy Indeks. The results of the analyses suggest that the number of positively ranked cities decreases as the city population size decreases: 100 % large cities are positively rated, 48 % medium cities and 6 % small cities.
UNDERSTANDING THE COMPLEXITY OF ASSESSING CULTURAL HERITAGE’S ECONOMIC IMPACT ON THE ECONOMIC SUSTAINABILITY OF A TOURISM DESTINATION: THE CASE OF SPLIT, CROATIA
Authors:   University of Zagreb, Croatia, Faculty of Economics & Business, Department of Tourism, Matečić Ingeborg , Kesar Oliver , Ferjanić Hodak Danijela
Published: December 2022

The purpose of this conceptual study is to define the possibilities and constraints of assessing the economic impact of tangible cultural heritage on the economic sustainability of a tourism destination. To achieve this goal, the following were critically analysed: (1) strengths and limitations of previously used assessment approaches and techniques; and (2) sustainable development indicators for urban tourism destinations that contain world-class cultural heritage sites. The case study used in this research is an urban cultural heritage site listed on the UNESCO World Heritage List, namely the Historical Complex of Split with the Palace of Diocletian, Croatia, and the associated tourism destination setting. Observational and case study methods were used. Despite all previous efforts to prevent miscalculations and develop a technique that would best suit the tangible cultural heritage valuation process, findings suggest that each cultural heritage site has unique characteristics and requires its own approach to assessing its value and impact. Moreover, such findings have further implications for the UNESCO World Heritage List and the management of World Heritage sites.
PROPOSAL OF CRM CONCEPTUAL MODEL/FRAMEWORK TO OPTIMISE RELATIONS AMONG STAKEHOLDERS OF HIGHER EDUCATION
Authors:   University of Sarajevo, Faculty of Traffic and Communications, Kosovac Amel , Grabovica Elvedin , Medić Adisa , Kalem Aida
Published: December 2022

In the present-day environment pertaining to digitalisation, increasing competition on the market and changes in industries, the CRM as a system is an essential tool for success. The issue of CRM system application in higher education institutions is insufficiently researched, especially in the parts that should indicate a clear connection between participants in higher education and CRM in higher education institutions, and factors that decision makers should pay attention to when making decisions about CRM implementation. Therefore, the aim of the paper is to research the functionality, application and advantages of CRM in the higher education sector, and to determine the features that will facilitate effective decision-making on the implementation of CRM. As a result of the research, a proposal for a conceptual model/framework of CRM was presented. The proposal is presented for the purpose of making appropriate decisions for higher education institutions when it comes to developing their own or purchasing a ready-made CRM solution. From the scientific aspect, the paper contributes to the existing literature by providing decision makers with an insight into the structure of the CRM system, its elements, connections and functionalities, as well as a description of the model with the information they need to pay attention to when making decisions.