bluuebunny/crossref_metadata_2025 huggingface dataset:
BLOOD PRESSURE PROFILES AMONG EAST BONGAS AND WEST BONGAS PEOPLE IN EFFORT AND SUPPORT FROM UNIVERSITAS PADJADJARAN AND THE REGENT OF MAJALENGKA REGENCY AND CHIEVES OF THE VILLAGES
Authors: D. Diah Dhianawaty , Heryaman Henhen , Syamsunarno Mas Rizky Anggun Adipurna
Published: June 2017

Objective: To support the people in East Bongas and West Bongas villages to prevent and treatment the hypertension disease.Methods: This was a cross-sectional design while the subjects were taken by a simple random sampling. A total of 323 families were included, and blood pressure of the male and female subjects aged between 18 to 65 y was measured and had been given a question relating to their blood pressure.Results: The blood pressure profile was classified based on the seventh report of the Joint National Committee (JNC 7). The youngest male and female participants of pre-hypertension were 18 and 22 y, respectively. The normal blood pressure, pre-hypertension, hypertension stage-1, and hypertension stage-2 were 34.3%, 49.5%, 12.1%, and 4.1%, respectively. Prevalence of patients with hypertension based on the age groups 30-39, 40-49, 50-59, and 60-69 y were 6.8%, 15.6%, 33.9%, and 37.3%, respectively. Prevalence of patients with hypertension in male was 16.8%, the female was 15.7%, and the total of both were 16.2%. Prevalence based on gender showed that those who had information about hypertension in male was 46.8%, the female was 47.9%, and the total of both were 47.4%. Prevalence of hypertension patients increased, for a male was 8.9%, the female was 8.2%, and the total of both were 8.5% after the participants declared that they were not hypertension patients.Conclusion: In both villages occurred an increase of hypertension prevalence. Based on this information, the people in two villages should be given the appropriate knowledge and awareness regarding hypertension.
PHYTOCHEMICAL INVESTIGATION, GC-MS PROFILE AND ANTIMICROBIAL ACTIVITY OF A MEDICINAL PLANT RUTA GRAVEOLENS L. FROM ETHIOPIA
Authors: Azalework Henok Gulilat , . Sahabjada , Jafri Asif , Arshad Md , Malik Tabarak
Published: June 2017

Objective: This study was designed to screen the phytochemicals present in various solvents extracts of Ruta graveolens (Rue) and furthermore to investigate their antimicrobial activity.Methods: The leaves, stems and seeds of Rue were extracted using four different solvents viz. ethanolic, methanolic, chloroform, and aqueous of varying polarity. The phytochemical screening was carried out qualitatively and Gas Chromatography-Mass Spectroscopy (GC-MS) analysis was performed to identify major phytoconstituents present in the methanolic leaf extract. The antimicrobial effect of extracts was evaluated against six microbial strains namely Bacillus subtillis, Escherichia coli, Proteus vulgaris, Candida albicans, Candida tropicalis and Micrococcus luteus with disc diffusion method.Results: Phytochemical analysis revealed the presence of various secondary metabolites such as flavonoids, alkaloids, terpenoids, saponins and carotenoid. The methanolic leaf extract showed the presence of both tannin and phenolic contents in the higher amount, whereas aqueous extract displayed in the least amount. GC-MS analysis of methanolic leaf extract revealed the presence of approximately 26 phytochemical constituents. The antimicrobial assay revealed that B. subtilis showed a high zone of inhibition (20 mm) at 200 mg/ml of methanolic extract. However, E. coli and C. tropicalis did not show any zone of inhibition against each solvent extract.Conclusion: In conclusion, secondary metabolites present in the extracts have biological activities which warrant further to evaluate in vivo pharmacological studies.
EFFECT OF EXTRACTS AQUEOUS OF PHRAGMITES AUSTRALIS ON CARBOHYDRATE METABOLISM, SOME ENZYME ACTIVITIES AND PANCREATIC ISLET TISSUE IN ALLOXAN-INDUCED DIABETIC RATS
Authors: Derouiche Samir , Azzi Manel , Hamida Abir
Published: June 2017

Objective: The present study was aimed to investigate the effects of the aqueous extract of rhizome of phragmites australis on carbohydrate metabolism, some enzyme activities and pancreatic tissue in alloxan induced diabetic rats.Methods: Wistar rats were divided into three groups (n=6) as control, diabetic group and test groups (Diabetic+AEPA). Diabetes in rats was induced by alloxane using a single peritoneal injection of 150 mg/kg dose. Aqueous extract of Phragmites australis was supplemented (200 mg/kg b. w) orally for three weeks. The aqueous extract of Phragmites australis was prepared and phytochemical were analyzed by using standard methods. Blood glucose level, pancreas histology and various biochemical parameters were assessed.Results: The results of the phytochemical analysis of aqueous extract of Phragmites australis (AEPA) revealed the presence of tannin, terpenoids, glycosides and flavonoids. Compared with the control, a significant decrease in the body weight gain (p<0.01) and increase in food intake (p<0.001) were noticed in the diabetic group. The biochemical evaluation showed significantly higher values for glucose (p<0.001), lipid profile (p<0.05), transaminases (p<0.05), amylase and alkaline phosphatase (p<0.001) activities in diabetic group compared with the control. Histology of the pancreas showed congestion of vessels and focal area of necrosis in diabetic untreated rats. However, treatment with aqueous extract of Phragmites australis significantly normalized blood glucose, serum biochemical profile and pancreas histomorphology.Conclusion: It is suggested that aqueous extract of Phragmites australis exhibits a benefic effect in rat to a great extent in attenuating and restoring the damage sustained by diabetes.
ALPHA AMYLASE AND ALPHA GLUCOSIDASE INHIBITION ACTIVITY OF SELECTED EDIBLE SEAWEEDS FROM SOUTH COAST AREA OF INDIA
Authors: Reka P. , A. Thahira Banu , Seethalakshmi M.
Published: June 2017

Objective: The present work was to investigate the alpha amylase and alpha-glucosidase inhibitory activity of the selected edible seaweeds.Methods: The seaweeds namely Acanthophora spicifera, Gracilaria corticata, Gracilaria edulis, Ulva lactuca and Ulva reticulata were selected for this study. Six and eight hours of ethanol and aqueous extract were used for the estimation of alpha amylase using DNS method and alpha-glucosidase inhibition activity.Results: The study reported that the solvent from ethanol and aqueous in eight hours of extraction showed a higher inhibitory activity than six hours of extraction. Maximum of 89.1±0.96 and 79.55±3.08 percent of alpha-amylase and alpha-glucosidase inhibition activity were detected in the eight hours of aqueous extract (0.5 ml) of Ulva reticulata and Gracilaria edulis respectively. All the selected edible seaweeds had significant differences (p<0.05) in alpha amylase and alpha glucosidase inhibition activity between the selected seaweeds with different extracts.Conclusion: It was concluded that all the selected edible seaweeds have the potential to act as a potent inhibitor of the carbohydrate hydrolyzing enzyme. Thus, it was clear from the study that seaweeds incorporated in small amounts in the dishes consumed in the daily diet can bring a control on postprandial blood glucose level.
DNA-BASED HYBRID LIQUID CRYSTALLINE NANO ORGANOMETALLIC COMPOSITES FOR TARGETED DRUG DELIVERY IN NEUTRON CAPTURE THERAPY
Authors: I Slivkina , V. Kondrashina O. , M. A. J Halahakoon , Sergeevna Belenova Alena
Published: June 2017

Objective: The aim of this work was focused on the obtaining a DNA-based hybrid nano liquid crystalline organometallic composites for targeted drug delivery in neutron capture therapy.Methods: The formation of a cholesteric liquid crystalline DNA (CLCD-DNA) dispersion has performed using ultrasonic depolymerized calf thymus DNA(MW-0.6-0.8×106Da)2×10-7M, mixing with polyethylene glycol8.5×10-5M, dissolved in the 0.3 M NaCl solution and incubated over 1,0 h at 20 °C. CLCD-DNA formation process was determined and controlled by measuring absorption value of circular dichroism (CD) spectrum in the range of 350-600 nm. The organometallic DNA-Gd compound was formed by processing the obtained CLCD-DNA with 2.49 × 10-4M, 4.97 × 10-4M, 9.8 × 10-4 M, 1.48× 10-3M, 2.92 × 10-3M GdCl3 aqueous solutions. CLCD-DNA-gadolinium complex formation process was registered over the appearance of 2nd amplitude in the CD spectrum. DNA-Gd complex dispersion toxicity was evaluated over 40 min, 24h and 72h incubation with 1×106cells in the RPMI-40 medium supplemented with 3×10-4 M Gd3+.Results: The obtained CLCD-DNA-Gd (d~500 nm) particles was shown less toxicity and higher viability percentage of macrophages after 40 min incubation with CLCD-DNA-Gd contains Gd3+ions concentration 3×10-4 M showed 100% viability and after 72 h ours approximately 89%. The cells immobilized with CLCD-DNA-Gd particles contains 3×10-4M Gd3+, neutron irritation was caused a 100% cell deaths.Conclusion: Obtained relatively stable, non-cytotoxic drug forms with a maximum local concentration of gadolinium (400 µg/ml). The effectiveness of these nanosystems for targeted drug delivery has markedly superior efficacy than 10B and other products were based on gadolinium.
MANAGING THE EARLY PHASE OF REHABILITATION AFTER ISCHEMIC CEREBROVASCULAR ACCIDENT
Authors: Gara Eqrem , Haxhiu Bekim , Durguti Zheralldin , Murtezani Ardiana
Published: June 2017

Objective: Ischemic cerebrovascular accident (ICA) is characterised by the rapid deterioration of brain function due to vascularization disorders. The ischemic cerebrovascular accident may arise as a consequence of ischemia or hemhorrage in brain tissue, but the optimal treatment approach is unclear. In this study, we examined ICA rehabilitation goals, implementation of rehabilitation plans, management of sensomotor deficits and functional status, improvement of independence, prevention and treatment of complications, functional status monitoring, and planning recommendations, as well as education of ICA patients and their families.Methods: This study considered 69 ICA patients who were classified as suitable for rehabilitation intervention among a total of 231 patients who were evaluated for a diagnosis of ICA following hospitalization at the Clinic of Neurology, University Clinical Center of Kosovo (UCCK) in Prishtina. From the statistical parameters, we used the structure index, whereas testing results were evaluated using the Chi-square test with significance established at p<0.05.Results: For the 69 ICA patients, most ICA incidents occurred in patients who were older than 40 y-old. Mobility decreased from 42.9% to 8.6% when rehabilitation began at release instead of admission. Meanwhile, the ability to perform daily activities decreased from 48.6% to 11.4% when rehabilitation began after release as opposed to immediately after stabilization. Transfers and balance showed similar decreases (48.6% to 11.4% and 48.6% to 11.4%, respectively Chi-test=59.7, p<0.001.). The rehabilitation of patients in the early acute stage after ICA should begin as soon as possible after the diagnosis is made and the patient's condition is stable. During rehabilitation intervention, priority should be given to preventing complications and recurrent stroke, as well as enhancing patient mobility and improving patient morale.Conclusion: ICA is a medical emergency that can cause permanent neurological lesions and other complications that may be fatal or associated with permanent disability. The most affected age group is individuals older than 40 y old. Neurological deficits can cause motor, sensory, functional and emotional disability in ICA patients. Rehabilitation after ICA should begin immediately after the patient has stabilized to minimze functional losses.
ANTI-INFLAMMATORY ACTIVITY OF CURCUMIN AND CAPSAICIN AUGMENTED IN COMBINATION
Authors: Kumar Thriveni Vasanth , H. Manjunatha , Kp Rajesh
Published: June 2017

Objective: Dietary curcumin and capsaicin are well known for their health beneficial potencies. The current study was done to assess the anti-inflammatory activity of curcumin, capsaicin and their combination by employing in vitro and in vivo models.Methods: We investigated the protective effect of curcumin, capsaicin and their combination using in vitro heat induced human red blood cell (HRBC) membrane stabilisation, in vivo 3% agar induced leukocyte mobilisation and acetic acid induced vascular permeability assay.Results: Curcumin, capsaicin and their combination exhibited concentration dependent protective effect against heat-induced HRBC membrane destabilisation, while combined curcumin and capsaicin restored 87.0±0.64 % membrane stability and it is found to be better than curcumin, capsaicin and diclofenac sodium (75.0±0.25. 72±0.9 and 80.0±0.31 %) protective effect. In agar suspension induced leukocyte mobilization assay, the combined curcumin and capsaicin had shown 39.5±1.58 % of inhibition compared to individual curcumin and capsaicin, which showed moderate inhibition of 16.0±3.14 and 21.6±2.17 % respectively. Besides, the combined curcumin and capsaicin had shown highly significant inhibition of acetic acid-induced vascular permeability in rats (62.0±3.14 %), whereas individual curcumin and capsaicin showed moderate inhibition of vascular permeability with 36.0±2.41 and 43.0±1.92 % respectively.Conclusion: This study demonstrates the significant anti-inflammatory property of combined curcumin and capsaicin at half of the individual concentration of curcumin and capsaicin.
LIPID PROFILE PATTERNS AND ASSOCIATION BETWEEN GLYCATED HAEMOGLOBIN (HbA1C) AND ATHEROGENIC INDEX OF PLASMA (AIP) IN DIABETES PATIENTS AT A TERTIARY CARE HOSPITAL IN MALAYSIA
Authors: Butt Mubashra , Ali Adliah Mhd , Bakry Mohd Makmor
Published: June 2017

Objective: There is lack of data regarding lipid patterns and the relationship of the atherogenic index of plasma (AIP with glycemic control in Malaysian diabetes patients. This study aimed to assess the lipid patterns and association of AIP with HbA1c in diabetes patients at a tertiary care hospital in Malaysia.Methods: The study was conducted on 72 diabetes patients who were randomly chosen and agreed to participate in the study. AIP values were calculated using log triglycerides/high-density lipoprotein (TG/HDL) ratio. Data were analysed using SPSS 23.Results: Mean age and body mass index (BMI) of the participants were 56.88±8.89 (years) and 28.81±4.78 (kg/m2) respectively. Hypercholesterolemia, hypertriglyceridemia, high low-density lipoprotein (LDL) values were found in 55.5 %, 41.7 %, 45.5 % of total participants respectively and less than desirable HDL values were observed in 25% of total participants. Overall, 37.5% patients were categorised into high-risk AIP category. BMI categories had a significant association with AIP category (p = 0.05). There was a significant positive correlation of AIP with HbA1c (r = 0.34; p = 0.0 04). HDL was negatively correlated with AIP (r = 0.27; p = 0.02). Duration of diabetes and ethnicity showed no significant association with AIP risk values.Conclusion: Diabetes patients in this study exhibited significant lipid abnormalities with increased AIP. AIP was significantly correlated with HbA1c.
STUDY ON IMPLICATIONS OF COPY NUMBER VARIATIONS (CNVs) IN HUMAN POPULATION
Authors: Yadav Anushka , Singh Pooja , Kumar Priya Ranjan , Srivastava Sarika , Mishra Santosh Kumar
Published: June 2017

Objective: To investigate the role and implications of copy number variations (CNVs) in different diseases found in the human population using various computational tools and databases.Methods: Five different diseases were taken into consideration namely Autism, Type-II Diabetes, Rheumatoid Arthritis, Breast Cancer, and Psoriasis. To validate the CNV's associated with various human diseases different tools and databases were used such as CNV annotator, DECIPHER, Database of Genomic Variants (DGV), CNVD, CNV Workshop, CNV Web store. Finally, the results were analysed to identify the extent of CNVs association in selected diseases.Results: Among all the selected diseases, the maximum numbers of CNV’s were found in the case of breast cancer which in total 3851 at chromosome number one. Among all the selected diseases, minimum numbers of CNV’s were found in the case of psoriasis, and a significant amount of CNVs are present in all the selected diseases.Conclusion: CNVs constitutes a substantial fraction of total genetic variability and it has the importance in modulating human diseases. This study has shown a significant presence of CNVs in all the selected diseases. Hence it can be concluded that CNVs can be major causing factors in many other life threatening diseases as well and a specific study designed to identify these variations can open a new dimension in the development of novel therapy for those diseases.
The modern features of epizootic process of anthrax in cattle populations in the Republic Of Chad
Authors: Dzupina S I , Yamtitina Mahamat Nguerabe
Published: June 2017

As in other African countries, anthrax in the Republic of Chad continues to be a big social problem and problem of livestock. Annually registered outbreaks of the disease in several regions, mainly in the rainy season. Long experience proves that the ongoing prevention of this disease has no effect on the sources and reservoirs of its causative agent.In order to prevent such outbreaks, it is necessary to study the features of the manifestation of epizootic process, and to identify ways of transmission mechanism and use them to control the disease.
Physicochemical properties of Polygonum multiflorum Thunb. root powder produced with different carrier agents
Authors: Quoc Le , Muoi Nguyen
Published: June 2017

Polyphenol is a valuable compound found in plants. Unfortunately, it is quite sensitive to heat, light and oxygen in the air. This is a disadvantage making the storage of these compounds for longer periods of time difficult. However, this problem can be overcome by encapsulation with carrier agents as maltodextrin, gum arabic, modified starch, etc. The efficiency of maltodextrin (MD, DE16-19) and gum arabic (GA) on spray drying of Polygonum multiflorum Thunb. root extract was investigated. The incorporation of gum arabic to the extract had the total polyphenol content (TPC) and antioxidant capacity (AC) higher than maltodextrin. The obtained powders from gum arabic and maltodextrin were analyzed for encapsulation yield, moisture content, color parameters, total phenolic content, antioxidant capacity, bulk density, wettability, hygroscopicity, water solubility index, particle size and microstructure. The results showed the types of carrier agents which significantly affected the physicochemical properties of powders produced by spray drying.
Externally imposed institutions and regional growth differences: Evidence from France and Germany
Authors: Guleryuz Ece
Published: June 2017

This paper provides a critical examination of effect of French Revolution institutions on regional economic development variations in 19th century by focusing on the experience of France. The argument in Daron Acemoglu et al. (2011) that differences in long-run economic performance of German states stem from differences in externally imposed French and domestic German institutions needs to be investigated further. A difference-in-difference estimation is used to identify a treatment effect causing growth differences between border and interior departments. The proposed treatment effect is the faster industrialization due to intensified minerals mining and railway construction in northern and northeastern France after 1850. It is shown that border departments experienced higher economic growth primarily after 1850 even though Revolution institutions and reforms were imposed in all of French departments. Therefore, externally imposed French Revolution institutions and reforms shouldn?t be counted as primary factors of causing variation in economic development across German polities.
Extraskeletal Ewing sarcoma in the anterior abdominal wall
Authors: Savic Djordje , Djuricic Slavisa , Milickovic Maja , Djokic Dragomir , Grujic Blagoje , Vukadin Miroslav , Samardzija Gordana
Published: June 2017

Introduction. Extraskeletal Ewing sarcoma (ES), is highly malignant neoplasm
occurring most commonly in the thoracic wall and paravertebral region. ES
belongs to the group of small round cell tumors and displays pathognomonic
structural abnormalities of EWS gene. The aims of this article was to present
extraskeletal ES in extremely rare anatomic location, an unusual clinical
presentation, and modified treatment strategy. Case outline. A 15-year-old
boy was admitted to the hospital with acute abdominal pain in the right iliac
region. During urgent operation, because of suspected appendicitis with
periappendicular infiltrate, partly haemorrhagic tumor tissue was discovered
in the preperitoneal space. Histopathological and immunohistochemical
analyses revealed tumor resembling extraskeletal ES. Postoperative CT scan
has shown the tumor rest, which was completely removed in the second
operation. The molecular genetic analysis confirmed extraskeletal ES by
finding of the EWSR1-FLI1 fusion gene. Chemotherapy and radiotherapy
according to VAC protocol were started, and the patient is free of the
disease eight months after the first operation. Conclusion. Our case is the
fourth case of extraskeletal ES located in the abdominal wall, the second
case confirmed by molecular genetic finding, and the first case described in
children at this anatomic location. Due to extremely rare location, unusual
clinical presentation, and needed genetic analysis, the strategy of tumor
treatment was modified with the good short-term result.
Desarrollo de la creatividad en la primaria a partir del cuento musical
Authors: Borislavovna Borislova Nadezhda
Published: June 2017

En años recientes se puede observar un creciente interés por estudiar a las personas creativas desde distintos enfoques y perspectivas, así como el rol y la función que la escuela tiene en todos los niveles educativos para el desarrollo de la creatividad. La creatividad es abordada y estudiada no solamente por los psicólogos, también por educadores, artistas, filósofos, biólogos, empresarios, entre otros. En las primeras dos décadas del siglo XXI, la creatividad se ha vuelto un sinónimo de educación, porque existe una necesidad urgente de educar a nuestros niños y jóvenes de una forma creativa, cambiar los esquemas convencionales  por los esquemas del pensamiento divergente, creativo y original que incentive el estudio y desarrollo de la creatividad.Escuchar el cuento musical como parte de las actividades de la educación artística dentro del currículo escolar, es una herramienta muy valiosa para el desarrollo de este potencial. El análisis de los resultados del estudio realizado con 582 niños de 1º a 6º grado de una escuela primaria pública de la ciudad de Puebla, conduce a la necesidad de incluir el cuento musical como parte del currículo de la educación artística. A pesar de una gran variedad del acervo literario-musical que nos ha dejado la historia, sobre todo en los últimos años. El cuento musical, por diversas razones, aún no ha sido explorado y utilizado con fines pedagógicos en la educación primaria. Por lo tanto, este trabajo plantea la necesidad de generar líneas de investigación específicas, enfocadas al estudio y desarrollo de la creatividad a partir de las artes que permitan el desarrollo integral de los niños en la educación básica a nivel primaria, al demostrarse que el cuento musical grabado motivó una transformación estadísticamente considerable del promedio de puntaje de creatividad (mismo que se incrementó de forma estadísticamente significativa en el post-test) en los grados 1º, 2º, 4º y 5º en específico, y al juntar a todos los niños de todos los grados (1º al 6º) que tomaron el test después del cuento musical.
Perhitungan Value at Risk Pada Portfolio Optimal: Studi Perbandingan Saham Syariah dan Saham Konvensional
Authors: Heryanti Sri Astuti
Published: June 2017

The aim of this study was to obtain empirical evidence about the difference between the level of risk when investing stocks in the Islamic and conventional by using Value at Risk (VaR). The object of research including consistent stock in the Jakarta Islamic Index and LQ45. The analytical method used in this research is quantitative analysis consisting of the establishment of the optimal portfolio by Markowitz method, calculation of VaR and testing the differences with Independent sample t-test. This study indicated that the value every stock can be reduced by diversifying through the establishment of an optimal portfolio. Based on the calculation Independent sample t-test, it is known that there is no difference between VaR of Islamic stocks and conventional stocks.
Crowd-sensing our Smart Cities: a Platform for Noise Monitoring and Acoustic Urban Planning
Authors: Zappatore Marco , Longo Antonella , Bochicchio Mario A.
Published: June 2017

Environmental pollution and the corresponding control measurements put in place to tackle it play a significant role in determining the actual quality of life in modern cities. Amongst the several pollutant that have to be faced on a daily basis, urban noise represent one of the most widely known for its already ascertained health-related issues. However, no systematic noise management and control activities are performed in the majority of European cities due to a series of limiting factors (e.g., expensive monitoring equipment, few available technician, scarce awareness of the problem in city managers). The recent advances in the Smart City model, which is being progressively adopted in many cities, nowadays offer multiple possibilities to improve the effectiveness in this area. The Mobile Crowd Sensing paradigm allows collecting data streams from smartphone built-in sensors on large geographical scales at no cost and without involving expert data captors, provided that an adequate IT infrastructure has been implemented to manage properly the gathered measurements. In this paper, we present an improved version of a MCS-based platform, named City Soundscape, which allows exploiting any Android-based device as a portable acoustic monitoring station and that offers city managers an effective and straightforward tool for planning Noise Reduction Interventions (NRIs) within their cities. The platform also now offers a new logical microservices architecture.
Bilateral Silent Sinus Syndrome: A Rare Case and Review of Literature
Authors: Trope Michal , Schwartz Joseph S. , Tajudeen Bobby A. , Kennedy David W.
Published: June 2017

Objective

In this report, we presented a rare case of bilateral silent sinus syndrome (SSS) in an otherwise healthy 57-year-old man treated with functional endoscopic sinus surgery (FESS). A systematic review of the literature regarding bilateral SSS was performed.

Case Report

A 57-year-old man with well-controlled allergic rhinitis in the absence of previous surgery or trauma presented with bilateral SSS, which was successfully managed with bilateral FESS.

Methods

A medical literature data base search of the terms “silent sinus syndrome” “maxillary atelectasis,” “imploding antrum syndrome,” and “bilateral silent sinus syndrome” was performed. The results were then narrowed to include only relevant articles.

Results

Relevant articles included three case reports and two articles that describe or mention bilateral SSS. Of the three case reports found, two patients presented with bilateral SSS, whereas the third patient presented metachronously, with the contralateral SSS manifesting 4 months after presentation of the initial ipsilateral SSS.

Conclusion

The present literature regarding bilateral SSS is likely incomplete, and further investigation is required to provide greater insight into the prevalence of this disease. In this report, bilateral FESS was successful in resolving symptoms and preventing disease progression.
Differential Expression of MicroRNAs and their Possible Roles in Patients with Chronic Idiopathic Urticaria and Active Hives
Authors: Lin Ching-Kow E. , Kaptein John S. , Sheikh Javed
Published: June 2017

Background

Chronic idiopathic urticaria (CIU) is a complicated skin disease with unknown pathophysiology. MicroRNAs (miRNA) have been shown to be active in cellular regulation. The goal of this pilot study was to examine whether miRNAs may be involved in the regulation of CIU or as biomarkers for CIU.

Methods

Four groups of three patients each were selected: patients with either active hives or no hives and with positive or negative chronic urticaria (CU) index results. MiRNAs were isolated from patient plasma and analyzed by using miRNA microarray technology to determine the amount of each of the 2567 known human miRNAs.

Results

A total of 16 miRNAs were found to be differentially expressed in patients with active hives. Among them, five (2355–3p, 4264, 2355–5p, 29c-5p, and 361–3p) were significantly increased in samples with positive CU index results, which could be useful biomarkers for patients with chronic autoimmune urticaria. The miRNA data bases were used to find the targets of these selected miRNA sequences. These potential targets were then compared against a list of 154 urticaria-related genes. Twenty-five genes were found to match. These included eight that were significantly downregulated and eight that were significantly upregulated; however, seven of the eight downregulated genes (FBXL20, OPHN1, YPEL2, STARD9, EZH1, KLHL24, ING4) and five of the eight upregulated genes (BYSL, PNO1, ADAMTS9, STEAP4, SRGN) have no reported roles in signaling. For the 13 genes with reported roles in signaling, the following pathways were found: transforming growth factor beta signaling pathway (NRC31, KITLG, THBS1, CCL2), glucocorticoid receptor signaling pathway (NR3C1, SELE, CCL2), p53 signaling pathway (CCNG2, THBS1, CCL2), p21-activated kinase pathway (PAK1IP1, KITLG, CCL2), phosphoinositide-3 kinase protein kinase B signaling pathway (KITLG, CHRM, THBS1), and neuroactive ligand-receptor interaction (NRC31, HRH1, CHRM), which could play important roles in CIU.

Conclusion

A better understanding of those genes with undefined function and simultaneous quantitation of both miRNAs and messenger RNAs are needed to fully understand CIU disease.
Myxofibrosarcoma of the Maxillary Sinus
Authors: Wong Anni , Park Richard Chan Woo , Mirani Neena M. , Eloy Jean Anderson
Published: June 2017

Background

Myxofibrosarcoma (MFS) is a common sarcoma in the extremities of older individuals but is extremely uncommon in the head and neck region. Diagnosis may be challenging but is critical to the management of the patient. We discuss the radiographic and histopathologic characteristics of this destructive tumor. The distinguishing features of MFS and its differential diagnosis are reviewed to familiarize the managing otolaryngologist with this rare entity.

Methods

A 61-year-old woman presents with a 6-week history of severe left facial pain and left eye pain. Imaging demonstrates significant right and left-sided maxillary sinus opacification with destruction of the left maxillary sinus as well as the left medial and inferior orbital walls.

Results

Histopathologic examination revealed spindle and stellate tumor cells of variable cellularity in myxoid stroma with cellular pleomorphism consistent with MFS of intermediate-to high grade. The patient underwent resection of the left-sided lesion with orbital exenteration and repair of the defect with microvascular free flap followed by postoperative radiotherapy.

Conclusion

MFS must be differentiated from other lesions with myxoid qualities. Histopathologic examination is required for definitive diagnosis. Management includes complete tumor excision with adequate tumor margins. Adjuvant postoperative radiotherapy should be considered for larger tumors with positive resection margins or lesions of intermediate-to-high grade.
Formulasi Pasta Gigi Berbahan Aktif Ekstrak Daun Sirih Hitam sebagai Antimikroba Penyebab Radang Gusi (Gingivitis) dan Gigi Berlubang (Caries)
Authors: Prasetya Fajar
Published: June 2017

This study aims to obtain a formula toothpaste preparations with active ingredient is extracts of black betel leaf which effectively kills microbes cause inflammation of the gums (gingivitis) and tooth perforated (caries). The active ingredient is obtained by performing maceration followed by fractionation of the extract. Test of antimicrobial activity against microorganisms Streptococcus mutans & Candida albicans using the diffusion method, which will get an effective concentration to be used for toothpaste formulations with active ingredient is black betel leaf. Then continued with the test and evaluation of the effectiveness of the final dosage form of toothpaste preparations. Obtained from the test concentration of 20% n-hexane extract fraction of black betel leaf have the greatest antimicrobial power against Streptococcus mutans and Candida albicans. And after optimization of the base, obtained the good mass forming of toothpaste with base PGA (Pulvis Gummi Arabica) at concentration of 30%.

Key words: antimicrobial activity, tooth paste, black betel leaf, formulations

 

ABSTRAK

Penelitian ini bertujuan untuk memperoleh formula sediaan pasta gigi berbahan aktif ekstrak sirih hitam yang efektif membunuh mikroba penyebab radang gusi (gingivitis) dan gigi berlubang (caries). Bahan aktif diperoleh dengan cara melakukan maserasi yang dilanjutkan dengan fraksinasi dari ekstrak tersebut. Uji aktivitas antimikroba terhadap mikroorganisme Streptococcus mutans & Candida albican menggunakan metode difusi, yang mana akan didapatkan konsentrasi efektif yang akan digunakan untuk formulasi pasta gigi berbahan aktif sirih hitam. Dilanjutkan dengan uji efektivitas dan evaluasi sediaan akhir berupa sediaan pasta gigi. Dari pengujian tersebut diperoleh konsentrasi 20% ekstrak fraksi n-heksana daun sirih hitam mempunyai daya antimikroba paling besar terhadap Streptococcus mutans dan Candida albican. Dan setelah dilakukan optimasi basis, didapatkan penggunaan basis PGA (Pulvis Gummi Arabica) pada konsentrasi 30% membentuk massa pasta gigi yang baik.

Kata kunci: aktivitas antimikroba, pasta gigi, daun sirih hitam, formulasi
Garam Gunung Asal Krayan sebagai Zat Aditif untuk Menstabilkan Klorofil Sayuran
Authors: Herman Herman , Rijai Laode
Published: June 2017

Garam Gunung Asal Krayan yang terdapat pada wilayah utara pulau Kalimantan dipercaya oleh masyarakat setempat untuk menyembuhkan berbagai macam penyakit seperti darah tinggi, kencing manis, penyakit kulit serta beberapa penyakit lainnya. Sayur yang menggunakan garam gunung terlihat lebih segar atau nampak tidak layu dan kesegarannya tahan lama dibandingkan dengan menggunakan garam biasa. Dilakukan penelitian untuk mengetahui efek garam gunung asal Krayan terhadap stabilitas sayuran dilihat dari perubahan kadar klorofilnya dengan beberapa perlakuan. Klorofil diukur absorbannya dengan menggunakan spektrofotometer pada panjang gelombang 649 nm dan 665 nm. Didapatkan hasil waktu penyimpanan sayuran yang menggunakan garam gunung asal Krayan yang masih mendekati klorofil sayuran segar adalah pada saat selesai pengolahan (0 jam) yaitu sebesar 22,11 ppm. Perubahan warna pada sayuran yang menggunakan garam gunung asal Krayan lebih lambat dibandingkan dengan garam biasa.
Kata Kunci : Garam gunung Krayan, sayuran, klorofil
Potensi Herba Tumbuhan Balsem (Polygala paniculata Linn) sebagai Sumber Bahan Farmasi Potensial
Authors: Rijai Laode
Published: June 2017

Tumbuhan balsem (P. paniculata) merupakan tumbuhan semusim yaitu dari biji lalu tumbuh dan akan mati setelah mencapai dewasa selama 4-5 bulan. Tumbuhan ini berbau balsem sehingga dinamakan tumbuhan balsem oleh masyarakat di Kalimantan Timur. Manfaat tradisional tumbuhan ini tidak banyak dikenal kecuali akarnya dipercaya dapat meningkatkan stamina. Belum banyak hasil penelitian ilmiah tumbuhan ini sehingga diperlukan informasi ilmiah untuk pemanfaatannya. Potensi biologi tumbuhan Balsemadalah mudah tumbuh dengan skilus hidup pendek yaitu 4-5 bulan. Beberapa hasil penelitian terhadap tumbuhan balsem terbukti memiliki potensi dalam bidang kefarmasian seperti sitotoksik atau antikanker, antibakteri, dan antimikotik. Potensi herba balsem juga digambarkan melalui kandungan metabolit sekundernya yaitu mengandung alkaloid, flavanoid, tanin, saponin, dan steroid. Keragaman metabolit sekunder tersebut menggambarkan kemungkinan masih memiliki potensi kefarmasian lainnya.
Kata Kunci: Herba Balsem (Polygala paniculata), sumber bahan farmasi potensial.
 
ABSTRACT
Plant balm (P. paniculata) is an annual plant that grows from the seed and will die after reaching mature for 4-5 months. This plant is so named smelling balm balm plant communities in East Kalimantan. Traditional benefits of this plant is not widely known but its roots are believed to increase stamina. Not many plants is the result of scientific research that is necessary for the utilization of scientific information. Potential biological plant is easy to grow with skilus Balsemadalah short life is 4-5 months. Several studies have proved the balsam plant potential in the field of pharmacy such as cytotoxic or anticancer, antibacterial, and antimycotic. Potential herbal balm is also illustrated through the content of secondary metabolites that contain alkaloids, flavonoids, tannins, saponins, and steroids. Illustrate the diversity of secondary metabolites may still have potential for other pharmacy.
Key Words: Antioxidant, Ageratum conyzoides L., Captosapelta Tomentosa V., Lepisanthes amoena, Acanthus ilicifolius L., DPPH
Uji Toksisitas Akut dan Subakut Pada Pemberian Ekstrak Etanol Bawang Tiwai (Eleutherine Americana Merr.)
Authors: Sastyarina Yurika
Published: June 2017

The ethanolic extract from the bulb of Eleutherine americana was investigated for acute and subacute toxicity in Balb/C male mice. The parameter used on this research is mortality n hepar  histophatological. During acute toxicity study, bulb plant (0.52, 0,26 and 5.2 mg/kg b.wt) p.o. for 72 hour and subacute toxicity study bulb plant (0.52, 0,26 and 5.2 mg/kg b.wt) p.o. once daily for 30 days. The result of the research shows that ethanol extract with 0.52, 0,26 and 5.2 mg/kg b.wt dosage can be said relatively safe because there is no death signal about 50% in 24 hour and the result of subacute toxicity in observation histophatological in hepar shows there is fibrosis n necrosis with 0.52, 2.6 mg/kg b.wt and 5.2 mg/kg b.wt dosage.

Keywords : bulb, Eleutherine americana , acute and subacute toxicity  

 

ABSTRAK

Telah dilakukan penelitian toksisitas subakut pada ekstrak etanol umbi bawang tiwai  (Eleutherine americana (Aubl.). Merr) dari mencit jantan. Parameter yang digunakan dalam penelitian ini adalah kematian dan hispatologi hati. Pada uji toksisitas akut diberikan ekstrak etanol bawang tiwai sekali dengan dosis 0,52 mg/kgBB, 2,6 mg/kgBB, dan 5,2 mg/kgBB dan dilakukan pengamatan selama 72 jam sedangkan pada toksisitas subakut dengan pemberian berulang setiap hari sekali selama 30 hari. Hasil penelitian menunjukkan bahwa bahwa ekstrak bawang tiwai dengan dosis 0,52 mg, 2,6 mg, dan 5,2 mg/KgBB dapat dikatakan relatif aman karena selama 24-72 jam tidak menunjukkan kematian hewan uji (mencit) sebanyak 50% dan hasil pengamatan hispatologi hepar menunjukkan bahwa dosis 0,52 mg/20 g bb mencit, 2,6 mg/20 g bb mencit, dan 5,2 mg/20 g bb mencit  dapat menyebabkan perubahan histologi hati mencit berupa fibrosis, nekrosis.

Kata Kunci : Umbi,  Eleutherine Americana, uji akut dan subakut
Stabilitas Fisik dan Kimia Minyak Biji Ketapang (Terminalia catappa L.) Selama Penyimpanan
Authors: Saputri Delima , Fitriani Victoria Yulita , Masruhim Muhammad Amir
Published: June 2017

Ketapang (Terminalia catappa L.) is each one potentialy to producting of nabati oil. The research is purposes to determine effect of storage period on room and extreme temperature of ketapang seeds oilâ€™s physical and chemical stability. Ketapang seeds oil was getted from ketapang seeds extraction by n-hexana with soxhletasi method. Ketapang seeds oil stability evaluation on room temperature 27 â€“ 30 Â°C as long as 50 days and extreme temperature 65 Â°C as long as 10 days. Physical stability that color, aroma, and flavor use organolepticly, pH use pH-meter, density use piknometer, and viscosity use Oswald viscometer. Chemical stability that acid value, peroxide value, and soap value by titration method, and amount of tocopherol compound by spectrometry method. The result data was analyzed with linier regretion. The analyzed result of aroma, flavor, pH, density, soap value, and tocopherol compound showed descend linier, viscosity, acid value, and peroxide value showed ascend linier, and color of ketapang seeds oil is stabil as long as storage on room and extreme temperature. Storage period on extreme temperature more significant than room temperature to effect evaluation result of ketapang seeds oilâ€™s physical and chemical parameters.

Key Words: Terminalia catappa L., Storage Period, Physical and Chemical Stability.

 

Abstrak

Ketapang (Terminalia catappa L.) merupakan salah satu tumbuhan yang berpotensi sebagai penghasil minyak nabati. Penelitian ini bertujuan untuk mengetahui pengaruh lama penyimpanan pada suhu ruang dan ekstrim terhadap stabilitas fisik dan kimia minyak biji ketapang. Minyak biji ketapang diperoleh dari ekstraksi biji ketapang dengan pelarut n-heksana menggunakan metode soxhletasi. Penentuan stabilitas fisik minyak meliputi warna, bau, dan rasa, pH, bobot jenis, dan viskositas. Penentuan stabilitas kimia meliputi penentuan angka asam, angka peroksida, dan angka penyabunan, serta kandungan tokoferol. Hasil pengujian dianalisis menggunakan regresi linier. Berdasarkan hasil analisis, disimpulkan bahwa pada parameter bau, rasa, pH, bobot jenis, angka penyabunan, dan kandungan tokoferol menunjukkan hubungan linier dengan kecenderungan turun, pengujian terhadap parameter viskositas, angka asam, dan angka peroksida menunjukkan hubungan linier dengan kecenderungan naik, sedangkan parameter warna minyak biji ketapang cenderung stabil selama penyimpanan pada suhu ruang maupun suhu ekstrim. Lama penyimpanan pada suhu ekstrim lebih signifikan mempengaruhi hasil pengujian pada parameter fisik dan kimia minyak biji ketapang dibandingkan pada suhu ruang.

Kata Kunci : Terminalia catappa L., Lama Penyimpanan, Stabilitas Fisik dan Kimia.
Penentuan Dosis Efektif Ekstrak Daun Pacar (Lawsonia inermis L.) sebagai Antiinflamasi
Authors: Megawati Selvi , Herman Herman , Masruhim Muhammad Amir
Published: June 2017

Has been conducted a research of dose determination of effectiveness extract of Lawsonia inermis L. as anti-inflammatory on Rattus norvegicus. The purpose of this research is to gain an in depth understanding of effective dose of Lawsonia inermis L. as anti-inflammatory toward the reduction time of swelling on Rattus norvegicusâ€™ feet .The method which being used was carrageenan induced on Rattus norvegicusâ€™ feet. Rattus norvegicus were devided to 6 (six) group which a group as negative control was given sodium CMC orally, a group as positive control was given Sodium Diclofenac orally, and 4 (four) as test was given extract with 4 doses variation (50mg/kg, 100mg/kg, 150 mg/kg, and 200 mg/kg) orally to each of mice that has pre-conditioned to swell on its foot. The result shows that T-Count is bigger than T-Table with significant standart 0,05 and smaller than T-Table with significant standart 0,01. It proves that there is significant difference between sodium diclofenac and extract of Lawsonia inermis L in 100mg/kgBW.  That concludes that extract of Lawsonia inermis L. has anti-inflammatory effect with effective dose as anti-inflammatory in 100mg/kg.

Keywords : Lawsonia inermis L., Anti-inflammatory., Rattus norvegicus.

 

Abstrak

Telah dilakukan penelitian penentuan dosis efektif ekstrak daun pacar (Lawsonia inermis L.) sebagai antiinflamasi pada tikus putih (Rattus norvegicus). Penelitian ini bertujuan untuk mengetahui dosis ekstrak daun pacar yang efektif sebagai antiinflamasi terhadap waktu penurunan bengkak pada kaki tikus putih. Metode yang digunakan yaitu induksi karagenan pada kaki tikus putih. Tikus putih dikelompokkan menjadi 6 kelompok yaitu kelompok kontrol negatif diberikan natrium CMC, kelompok kontrol positif diberikan natrium diklofenak dan 4 kelompok uji diberikan ekstrak dengan 4 variasi dosis yaitu 50 mg/kg, 100 mg/kg, 150 mg/kg dan 200 mg/kg yang masing-masing diberikan secara oral dan tiap kaki tikus dikondisikan bengkak terlebih dahulu. Hasil penelitian ini membuktikan ekstrak daun pacar memiliki kemampuan sebagai antiinflamasi dengan dosis efektif 100 mg/kgBB.

Kata Kunci: Lawsonia inermis L., Antiinflamasi, Rattus norvegicus.
Potensi Tumbuhan Tembelekan (Lantana camara Linn) Sebagai Sumber Bahan Farmasi Potensial
Authors: Rijai Laode
Published: June 2017

Tumbuhan Tembelekan dianggap masyarakat sebagai pengganggu atau gulma karena pertumbuhannya yang dahsyat merambat ke segala arah sehingga mengganggu pada kegiatan pembukaan lahan. Manfaat tradisional daun tumbuhan ini dikenal oleh berbagai suku di Indonesia, tetapi hanya sebagai obat luka yang tidak menarik karena obat luka tergolong obat murah di pasaran. Potensi botani yang tampak terhadap tumbuhan Tembelekan adalah pertumbuhannya yang dahsyat sehingga jika memiliki manfaat ekonomi menjadi sangat potensial ditinjau dari penyediaan bahan baku. Beberapa penelitian ilmiah telah dilakukan terhadap daun dan bunga Tembelekan dan terbuktidaunnya sangat potensial sebagai obat luka yang melebihi obat luka bioplacenton dan bunganya bersifat antioksidan yang sangat kuat.Kandungan metabolit sekunder daun dan bunganya juga sangat bervariasi sehingga masih memungkinkan potensi-potensi lainya dalam bidang farmasi.
Kata Kunci: Tembelekan (Lantana camara L), sumber bahan farmasi potensial
Ảnh hưởng của xâm nhập lạnh sâu đến mưa ở Việt Nam
Authors: Tiến Trần Tân
Published: June 2017

Abstract
Ứng dụng mô hình Mike 11 mô phỏng quá trình lan truyền chất ô nhiễm do nuôi trồng thủy sản trên một số sông lớn tỉnh Quảng Trị
Authors: Anh Tuấn Nguyễn Vũ , Hưng Nguyễn Quang , Sơn Nguyễn Thanh , Liên Nguyễn Thị
Published: June 2017

Abstract
Mô phỏng trường dòng chảy đáy trung bình tháng tại khu vực biển Bắc Trung Bộ bằng mô hình ROMS
Authors: Vui Vũ Thị
Published: June 2017

Abstract
Governance of interorganizational relationships: The case of science and technology parks
Authors: Guedes Laimer Claudionor
Published: June 2017

Este artículo tiene como objetivo identificar las formas de gobernanza que están presentes en las relaciones interorganizacionales en el contexto de parques científicos y tecnológicos. Por lo tanto, el estudio presenta un análisis comparativo de la gobernanza de parques científicos y tecnológicos. Así, se utilizó el estudio de casos múltiples como una estrategia de investigación, incluyendo un parque en Brasil y otro en Portugal. Uno de los parques fue creado por el sector privado por la necesidad de las empresas en compartir recursos y buscar alternativas de crecimiento. El otro fue creado por el gobierno como consecuencia de las políticas públicas para el desarrollo económico y la generación de empleo y renta. Los resultados muestran que los casos estudiados se caracterizan por la organización administrativa, como la forma de gobernanza de las relaciones interorganizacionales. Sin embargo, la forma de gobernanza y los mecanismos formales e informales de gobernanza son las principales conclusiones. Hay otros elementos (e.g., el comportamiento de la gente) que pueden influir en las relaciones interorganizacionales en el contexto del parque científico y tecnológico. Por último, el artículo ofrece una discusión de las implicaciones teóricas y prácticas del estudio