bluuebunny/crossref_metadata_2025 huggingface dataset:
Delayed Facial Palsy: Uncommon Complications Of Microvascular Decompression For Hemifacial Spasm
Authors: Syah Faris Khairuddin , Hutabarat Ervina
Published: October 2023

Background: Microvascular Decompression (MVD) is considered the most effective treatment for reducing hemifacial spasm (HFS) and achieving long-term resolution. However, in rare cases, this procedure can lead to delayed facial palsy, characterized by facial weakness occurring more than 24 hours after surgery.
Case: A 50-year-old woman complaining of twitching in the right face, from the corner of the eye to the eyebrows and mouth, for 2 years. The Brain MRI-FIESTA examination revealed a neurovascular attachment between the right facial nerve and the right posterior inferior cerebellar artery. Despite receiving medical treatment, the patient experienced dissatisfaction due to incomplete symptom remission and drowsiness caused by drug side effects. After the patient undergoes MVD, the twitches disappeared. However, twelve days later, the patient developed right facial weakness, and after three months of rehabilitation, facial weakness was resolved.
Discussion: HFS is a rare condition characterized by involuntary facial twitches that can significantly disrupt daily activities, despite being painless. Proper management according to patient needs and the choices of HFS management include medications, botulinum toxin injection, and MVD. The potential side effects of each procedure should be carefully considered when making treatment decisions. It is crucial to thoroughly evaluate and monitor post-surgical conditions. Delayed facial weakness may be attributed to gradual edema occurring after surgery. The use of Teflon to separate nerve tissue and blood vessels, although beneficial, can sometimes be perceived as a foreign body leading to inflammation. Facial weakness can be managed with facial muscle exercises without requiring special treatment.
Cases Of Meige’s Syndrome Controlled Following Administration Of Low-Dose Botulinum Toxin Type-A: A Serial Case Series
Authors: Ketaren Retno Jayantri , Margono Jacqueline Tasha , Stevano Reza
Published: October 2023

Background: Meige syndrome is a form of cranial dystonia characterised by blepharospasm and oromandibular dystonia, with a twice-fold higher prevalence in women as compared to men. The definitive pathophysiology underlying Meige syndrome remains unknown, but some studies have postulated the role of striatal dopaminergic activity. Currently, no curative treatments are available for Meige syndrome, but non-specific modalities include oral agents such as anti-cholinergics, dopaminergics, and benzodiazepines. Botulinum toxin Type-A (BoNTA) constitutes an effective treatment option in cases of Meige syndrome refractory to oral management.
Case summary: We report three cases of female patients, age 42, 57, and 61 years, presenting with complaints of blepharospasm and oromandibular dystonia. Low-dose BoNTA injections were administered, 10 units total weekly divided into the orbicularis oculi, corrugator supercilii, frontalis, procerus, nasalis, zygomaticus, mentalis, dan risorius, and orbicularis oris areas. Following repeated administrations of BoNTA injections, the three patients no longer experience symptoms up till now.
Conclusion: The authors report that low-dose BoNTA injections are effective in ameliorating dystonic symptoms associated with Meige syndrome, with low incidences of side effects.
An Investigation on the Components of the Living Standards: Evidence from Ethiopia
Authors: KARAPINAR KOCAĞ Esra
Published: October 2023

Adaption of the 2030 Agenda for Sustainable Development in 2015 by United Nations member states is an urgent call for action to improve human lives while protecting environment. As any other developed and developing members, Ethiopia is also expected to response the call for action. Ethiopia is a country with high dependency on rain-fed agriculture, severe drought as a result of climate change and wrong human action, widespread poverty, and high dependency on humanitarian aid which requires a careful investigation to deal with its problematic situations. This paper offers a household level investigation on the components of living standards or welfare in Ethiopia, utilising COVID-19 High Frequency Phone Survey of Households 2020. Findings suggest that living area, ownership of dwelling, Access to water and electricity, having a rental income, and the number of household members significantly associated with the level of consumption, that are expected to provide guidance for policy makers.
Türkiye’de Kadın İstihdamının Genel Görünümü: İstihdamın Artırılması Kapsamında Seçilmiş Ülke Örnekleri
Authors: AYTA Feyzagül , ŞEN Mustafa
Published: October 2023

Türkiye’de dezavantajlı gruplar içerisinde yer alan kadınların istihdamı geçmişten günümüze önemli bir sorun alanını teşkil etmektedir. Geleneksel düşünce yapısı, ev işi yükü, bakım sorumlulukları, cinsiyet ayrımcılığı, cam tavan sendromu, ücret eşitsizliği, eğitim gibi sorunlar kadın istihdamının düşük oranlarda kalmasına neden olmaktadır. Son dönemde kadın istihdam oranında yaşanan artışa rağmen Türkiye, AB ve OECD ülkeleri içerisinde en düşük kadın istihdam oranına sahiptir. Çalışmada AB ve OECD ülkeleri ile Türkiye’de kadınların işgücü istatistikleri karşılaştırılmış ve kadın istihdamının yüksek olduğu bazı ülke örneklerine yer verilerek bu ülkelerin çalışma hayatı içerisinde kadınlara yönelik uyguladıkları politikalar ele alınmıştır. Bu örnek ülkelerde var olan politikaların Türkiye’de uygulanabilirliği açısından değerlendirilmesi ve kadın istihdamının artırılması için çeşitli öneri ve görüşlerin sunulması çalışmanın amacını oluşturmaktadır. Bu doğrultuda Türkiye’de kadın istihdamında istenilen hedeflere ulaşılabilmesi için kadınların çalışma yaşamında daha fazla yer almasını sağlayacak politikaların artırılması ve etkin bir şekilde uygulanması gerekmektedir.
Pengembangan Aplikasi Evaluasi Pembelajaran Wizer.Me pada Mata Pelajaran IPS di MTs Darussalam Aryojeding
Authors: Basrina Yulya , Afryansih Nila , Febriani Trina
Published: October 2023

This study aims to determine and analyze the development, feasibility and practicality of the Development of Evaluation Media Using the Wizer.me Application on Student Learning Outcomes in Social Studies Subjects at MTs Darussalam Aryojeding.The type of research used in this research is research and development (Research and Development). The 4D model includes 4 stages, namely: Define, Design, Development, and Desiminate. The subjects in this study were students of class VIII A and class VIII C who participated in social studies learning at MTs Darusalam Aryojeding 2021/2022, with a total of 82 students.

The results of the study found that: 1.) Media development Evaluation includes validation from experts, namely media experts, education experts, linguists and IT experts. So that media validation data is obtained which is then processed with the Interaclass Coefitien Correlation (ICC) formula, assisted by processing using the SPSS version 22 application for Windows, the results are 0.974. if the value is more than 0.5 then it can be concluded that the level of validation is sufficient. 2.) Evaluation media using Wizer.me was declared very feasible after analyzing data processing using Microsoft Excel so that a total score of 1312 was obtained with an average level of 4.0 and a percentage level of 88% with the predicate "Very Eligible". 3.) The evaluation media using Wizer.me was declared practical after processing the research data obtained from the questionnaire, and a practical test was carried out so that a total score of 881 was obtained with an average level of 4.45 and a percentage of 86% in the "Very Practical" category.
Analisis Kondisi Atmosfer Saat Kejadian Hujan Lebat di Sintang Menggunakan Satelit Cuaca dan Model ECMWF (Kasus: 30 September 2021)
Authors: Purwanti Siti Dwi , Weyai Silas Leonardus , Haryanto Yosafat Donni , Mulya Aditya
Published: October 2023

Hujan berintensitas lebat yang berlangsung selama beberapa jam pada tanggal 30 September 2021 di Kabupaten Sintang memicu terjadinya banjir selama 1 bulan di wilayah tersebut. Berdasarkan nilai curah hujan yang tercatat pada Stasiun Meteorologi Susilo – Sintang, pada tanggal 30 september 2021 curah hujan mencapai 139,5 mm/hari. Penelitian ini dilakukan untuk mengetahui kondisi atmosfer yang berpengaruh secara global, regional dan lokal saat kejadian hujan. Data yang digunakan adalah data indeks NINO 3.4, IOD, MJO, streamline, SST, dan indeks stabilitas atmosfer (CAPE, KI, dan TTI) yang diperoleh dari pemodelan, data pengamatan sinoptik (kelembapan relatif dan curah hujan) yang diperoleh dari pengamatan di Stamet Sintang, dan data Satelit Himawari-8 yang diperoleh dari Sub Bidang Pusat Pengelolaan Citra Satelit BMKG. Hasil penelitian menunjukkan bahwa pada tanggal 30 September 2021 di Kabupaten Sintang, Kalimantan Barat terdapat aktivitas yang memicu pertumbuhan awan-awan konvektif baik dari skala global, regional, dan lokal sehingga menghasilkan hujan dengan intensitas yang sangat lebat.
Identifikasi Kasus Insidensi Memar (Bruising) pada Karkas Sapi di Rumah Potong Hewan Tanah Merah Samarinda
Authors: Wibowo Ari , Suhardi  , Rahman Muhammad Aulia
Published: October 2023

Penanganan pra-penyembelihan adalah semua aktivitas dan proses yang harus ternak lewati. Aktivitas dan proses terjadi pada semua tempat yaitu kandang, kendaraan transportasi, dan pada rumah potong hewan, proses penanganan pra- penyembelihan yang salah dapat menyebabkan memar pada tubuh ternak. Memar adalah hasil dari trauma ke otot tubuh, Karakteristik memar seperti ukuran, bentuk, warna dapat memberikan informasi mengenai kurangnya kesejahteraan hewan. Tujuan dari penelitian ialah untuk mengetahui persentase memar yang terjadi selama proses pre-slaughter handling, dan mengidentifikasi penyebab memar di Rumah Potong Hewan Tanah Merah Samarinda. Penelitian dilaksanakan pada bulan Desember 2021 hingga Februari 2022 di Rumah Potong Hewan (RPH) Tanah Merah Samarinda, sampel diambil menggunakan metode purposive sampling dengan menggunakan 377 karkas sapi bali dari NTT dan Sulawesi serta Sapi PO. Data yang telah di peroleh dianalisa menggunakan analisis statistik deskriptif dan dihitung dalam bentuk persentase (%). Berdasarkan hasil pengamatan atau observasi menunjukan tingkat kejadian Memar pada karkas adalah sebagai berikut: didapati sebanyak 44,8% karkas memiliki memar dan 55,2% karkas tidak memiliki memar, mayoritas memar berwarna merah muda dengan persentase 20,4%, mayoritas memar terjadi pada bagian butt dengan persentase 34,2% dan bentuk memar yang paling dominan adalah bentuk irregular dan circular sebanyak 23,3% dan 16,4% secara berurutan. Disimpulkan bahwa Sebagian besar memar terdapat pada karkas di RPH Tanah Merah Samarinda terjadi ketika ternak dikekang dan dirobohkan sebelum disembelih dan saat ternak berada di dalam transportasi.
Performan Ayam yang Diberi Pakan Additive
Authors: PERMADI I GEDE WEMPI DODY SURYA , Novita Risqa , Altandjung Ririen Indriawaty , Gunawan
Published: October 2023

ABSTRACT
Broiler chickens (broilers) are very popular as chickens for consuming animal protein because they are easy to maintain and only take about one month for broiler chickens to be consumed. Chicken farm management such as DOC, housing systems, maintenance and feed systems are critical points in farm management. Feed is the biggest cost in livestock management. The increase in the price of corn causes an imbalance in the output and input of livestock management. In addition to a source of corn substitute chicken feed, researchers are also developing additive feed as additional feed to fulfill protein and crude fiber. This writing uses a systematic review method based on journal articles, theses, theses and books on chicken feed and feed additives. The keywords used in the selection of articles are chicken feed journals, feed additives. Google schoolar and pop 8 win database are used for browsing articles on the internet
entorno del centro como fuente para construir situaciones de aprendizaje
Authors: Moreno Oviedo Jesús
Published: October 2023

Este artículo pretende defender la idea de la docencia al aire libre como una modalidad de enseñanza y aprendizaje, que, además de su carácter innovador, tiene un fuerte potencial a la hora de generar situaciones de aprendizaje. Para demostrarlo y, aprovechando una serie de experiencias que se desarrollaron en el IES Isla de León desde el curso 2020-2021, se va defendiendo su papel como conector con los retos y objetivos del desarrollo sostenible, como metodología activa que parte de las experiencias del alumnado, que estimula la reflexión, el espíritu crítico y la creatividad en situaciones contextualizadas, abiertas, flexibles y significativas. Todo ello permite un aprendizaje inclusivo que favorece la gestión emocional del alumnado. Algunas de las evidencias y resultados en diferentes asignaturas son ejemplificadas, concluyéndose la disposición y la acogida muy positiva por parte del alumnado, pero también las limitaciones dentro de una organización y horario lectivo poco flexible para afrontar esta línea educativa
Historia como práctica en Secundaria y Bachillerato. El pasado en las aulas.
Authors: Galbán Malagón Carlos José
Published: October 2023

La recreación y la experiencia del pasado a través de las fuentes históricas ayudan a comprender la configuración del discurso histórico. Así, se muestran varias actividades basadas en la práctica docente cotidiana que, sin requerir de costosos medios, acercan al alumnado a la metodología histórica y a sus fuentes de conocimiento. Esta vía se revela útil de cara a la presentación de contenidos y logro competencial pero también como una forma de mejorar el clima en el aula y la práctica del propio docente. Ya sea mediante un acercamiento distinto a la Primera Guerra Mundial, a la escritura medieval o a los juegos la idea de fondo no es realmente qué se enseña sino cómo.
Educación para el Desarrollo Sostenible y la Ciudadanía Mundial. Valoración de un programa de prácticas universitarias en Didáctica de las Ciencias Sociales
Authors: Martín-Arroyo Sánchez Daniel Jesús , Ballesteros Alarcón Vicente Marcial
Published: October 2023

Sostenibilidad y compromiso cívico son dos objetivos a escala mundial que se deben perseguir desde la educación. La complejidad de la tarea requiere un buen desarrollo estratégico de la metodología didáctica, tanto a través de la planificación de actividades como de la creación de herramientas para valorar los conocimientos adquiridos y las percepciones del alumnado. En este sentido, se ha implementado un programa de tres ejercicios prácticos, realizados y valorados por estudiantes del Grado en Educación Primaria de la Universidad de Granada. Las encuestas realizadas a tal efecto muestran resultados positivos a nivel cuantitativo. Sin embargo, el análisis crítico de estos datos ha contribuido a la identificación de posibles puntos débiles en la planificación de las prácticas y/o su ejecución durante el curso 2022-2023. La perspectiva resultante plantea el sentido de las mejoras a efectuar en el futuro desarrollo del programa de prácticas, de manera extrapolable a otros programas similares.
Motivar para aprender ciencias sociales en el contexto de la pandemia. Tres intervenciones didácticas motivadoras
Authors: Porrinas González David , Merchán García María José , Corrales Serrano Mario
Published: October 2023

Una de las tareas más importantes de un docente es la de desarrollar estrategias de aprendizaje que resulten motivadoras para el alumnado. En todas las etapas educativas y en cualquiera de las áreas de conocimiento, motivar al alumnado es una necesidad para que el proceso de aprendizaje tenga éxito. De manera especial, en el contexto de la pandemia del COVID 19, se hizo más necesario aún el trabajo motivacional con los discentes, para superar las dificultades de todos los niveles que se vivían en este contexto. La presente investigación presenta y analiza tres intervenciones didácticas llevadas a cabo durante el periodo de confinamiento derivado de la pandemia, en las etapas universitaria y preuniversitaria, y que tienen en común la finalidad de incidir en la motivación del alumnado para tratar de contrarrestar las circunstancias adversas de este periodo. Tras analizar de modo preliminar estas intervenciones, mediante los productos finales obtenidos y la observación participante del docente, se concluye que dichas intervenciones repercutieron positivamente en la motivación del alumnado, ayudando a superar las dificultades de aprendizaje propias de este contexto.
Inovasi Pangan Lokal: Pelatihan Pembuatan Stick Olahan Janggelan pada Ibu-Ibu Desa Nawangan
Authors: Mukib Yusuf , Pratiwi Endang , Wulandari Risma , Efendi Kurniana Yusuf , Alfindana Dicky
Published: October 2023

Pelatihan Pembuatan Stick Olahan Janggelan bertujuan untuk meningkatkan pengetahuan dan keterampilan Ibu-ibu desa Nawangan dalam mengolah pangan lokal menjadi produk bernilai tambah. Metode pengabdian ini melibatkan tahap observasi awal untuk memahami konteks dan kebutuhan ibu-ibu desa. Selanjutnya, tahap eksperimen dilaksanakan melalui sesi interaktif yang menggabungkan pengajaran teori dan praktek dalam pembuatan stick olahan janggelan. Selama tahap pelaksanaan, para peserta terlibat dalam pembelajaran langsung, diskusi, dan evaluasi terhadap kemajuan mereka. Hasil pengabdian menunjukkan bahwa pelatihan efektif dalam meningkatkan keterampilan teknis dan pengetahuan teoritis peserta. Partisipan menunjukkan peningkatan signifikan dalam kemampuan mengolah bahan baku, menerapkan teknik pengolahan, dan memahami nilai gizi dari produk olahan. Selain itu, pelatihan ini juga berhasil memperkuat ikatan sosial dalam komunitas, mendorong kolaborasi, dan mempromosikan budaya konsumsi pangan lokal. Pelatihan Pembuatan Stick Olahan Janggelan memberikan kontribusi positif dalam pengembangan keterampilan praktis, pemahaman teoritis, dan pemberdayaan Ibu-ibu desa Nawangan.
Pelatihan Teknik Dasar Tenis Meja Forehand Topspin pada Pemain Tenis Meja Tingkat Rekreasi di PTM KB Pacitan
Authors: Pradana Kartyas Argya
Published: October 2023

Tujuan kegiatan pengabdian masyarakat ini adalah membantu pemain tenis meja tingkat rekreasi PTM KB Pacitan dalam mengembangkan teknik dasar tingkat advanced yaitu forehand topspin agar permainan lebih menarik dan memberikan lebih banyak kesenangan sebagai olahraga rekreasi. Tahapan yang dilakukan meliputi : (1) survey lokasi, (2) berkoordinasi dengan pengurus PTM KB Pacitan, (3) menyusun jadwal, dan (4) melaksanakan kegiatan. Metode yang digunakan meliputi : (1) edukasi, (2) demonstrasi, (3) pendampingan praktik, dan (4) evaluasi. Sebenarnya para pemain tenis meja tingkat rekreasi sudah mengenal teknik forehand topspin, namun belum dapat menggunakannya secara efektif.
Amygdala and hippocampal contributions to broad autism phenotype: Project Ice Storm
Authors: King Suzanne , Li Xinyuan , Qureshi Muhammad , Laplante David , Elgbeili Guillaume , Jones Sherri , Rosa-Neto Pedro
Published: October 2023

Individuals with autism inconsistently exhibit increased or decreased volumes and functional connectivity of the whole amygdala and the whole hippocampus. Given heterogeneous structures of the amygdala and hippocampus and the heterogeneity of autism symptoms, it is worth examining how their subregions contribute to different autism phenotypes. T1-weighted and resting-state functional MRI data were acquired from 32 young adults of mothers who were pregnant during, or within 3 months of, the 1998 Quebec ice storm. Their broad autism phenotype was self-reported, including aloof personality, pragmatic language impairment and rigid personality. Volumes of the amygdala nuclei and hippocampal subfields were calculated. Seed-to-voxel analysis was applied to examine functional connectivity of the amygdala nuclei and hippocampal subfields with the rest of the brain, and linear regressions were implemented to examine associations of volume and functional connectivity with the three autism phenotypes. We found that 1) pragmatic language impairment was associated with increased right medial amygdala volume; 2) rigid personality was associated with decreased left hippocampal cornu ammonis (CA)1 volume; 3) pragmatic language impairment was associated with decreased left hippocampal CA1 connectivity with the supplementary motor area, and increased right hippocampal CA4 connectivity with the left putamen; and 4) rigid personality was associated with increased right central amygdala connectivity with the left inferior lateral occipital cortex (LOC); and increased left hippocampal CA3 connectivity with the right superior parietal lobule, increased right hippocampal CA4 connectivity with the left superior LOC, and increased right hippocampal dentate gyrus connectivity with the left superior LOC. In contrast, we found no associations with aloof personality. Our results suggest that amygdala and hippocampal structure and function contribute differently to two different autistic-like characteristics, with amygdala volume and hippocampus-motor connectivity explaining variance in communication impairment, and with hippocampal volume, amygdala- and hippocampus- sensory connectivity sharing the common mechanism in rigid behaviors.
Post-stroke apathy biotypes and their relation to the effort-based reward decision network: a resting-state fMRI study
Authors: Sun Wen , Fang Yirong , Wang Jinjing , Yin Dawei , jiang shiyi , Chao Xian , Zhang Feng , Yan Dingyi , Zhang Pan , Wang Peng , Liu Xinfeng
Published: October 2023

Post-stroke apathy (PSA) is a highly heterogeneous disorder that affects approximately 30% of stroke survivors. Nevertheless, comprehensive understanding regarding neurobiological mechanisms the heterogeneity of PSA is lacking. We hypothesized that the effort-based reward decision network (ERDN) may play a critical role in PSA heterogeneity. Therefore, we prospectively recruited 190 patients with acute ischemic stroke and 50 demographically matched healthy controls. Sparse canonical correlation analysis (SCCA) was employed to elucidate the associations between symptoms of PSA and patterns of resting-state functional magnetic resonance imaging (rsfMRI) functional connectivity. Through the application of hierarchical clustering, we successfully identified four distinct PSA biotypes based on their unique connectivity profiles. Biotype 1 had high levels of both apathy and depression at baseline. Biotype 2 had consistently higher levels of apathy but lower levels of depression at baseline. Biotype 3 had low levels of apathy and depression at baseline and follow-up. Biotype 4 had higher levels of depression but lower levels of apathy at baseline and follow-up. Furthermore, biotype1, 2 and 3 had varying degrees of increased scores on different dimensions of apathy relative to the overall mean. We used machine learning to evaluate the predictive performance of the ERDN connectivity model compared to the whole-brain connectivity model. Our results indicate that the ERDN model exhibited similar or superior predictive capabilities compared to the whole-brain model in biotype 1 and 2. The multiscale rsfMRI parameters in the ERDN were investigated further. Only biotypes 1 and 2 deviated from the overall mean in terms of graph-theoretic parameters, with biotype 1 having lower values and biotype 2 having higher values. On the other hand, these biotypes displayed distinct characteristics in terms of their functional separation parameters. Our study emphasizes the importance of ERDN in PSA heterogeneity and provides new insights for future research and therapeutic targets.
Finite element analysis and clinical application of 3D-printed Ti alloy implant for the reconstruction of mandibular defects
Authors: Xue Runqi , Lai Qingguo , Xing Hongyu , Zhong Chiyang , Zhao Yixuan , Zhu Kaiwen , Deng Yanwei , Liu Chengbin
Published: October 2023

Background The reconstruction of segmental defect of the mandible has always been a challenge. The customized reconstruction plate without a bone graft is also considered a transitional means of rehabilitation and reconstruction in some cases.Methods This study evaluated the biomechanical behaviors of customized plates with different structural designs comparing with commercial plates using the finite element method in reconstrution of the lateral mandible defect.Results Simulations revealed the stress state in the plate bodies, bone tissues and screws were associated with the width, height, thickness of the plates as well as the distribution of screws. In all of the groups, the system of 16 mm-high, 2.8 mm-thick customized reconstruction plate with 10 screws was considered to be the most ideal design because of the most harmonious biomechanical state. What’s more, the stress shielding effects were not obvious in this experiment. Based on the above findings, we conducted a clinical case analysis to verify the mechanical properties of customized reconstruction and obtained a satisfactory operation result.Conclusions The results show that by adjusting the contour parameters of the reconstruction plates, an ideal and reliable customized plate can be manufactured. And the customized 3D-printed Ti alloy implant will be a new way to achieve mandibular reconstruction in patients unable to perform autologous bone graft surgery.Trial registration: The present trial has been registered with ChiCTR, the registration number is ChiCTR 2000038973 on 11/10/2020.
Langerhans cell histiocytosis in children with refractory diarrhea and hypoalbuminemia as the initial presentation: two cases report and literature review
Authors: Cao Yi , Wu Qing-Qing , Yan Wei-Hui , Lu Li-Na , Tao Yi-Jing , Feng Hai-Xia , Chu Yi-Jing , Cai Wei , Wang Ying
Published: October 2023

Langerhans cell histiocytosis (LCH) with involvement of the gastrointestinal tract is rare and lack of clinical experience. We describe two cases who initially presented with chronic diarrhea, hypoproteinemia, and intermittent fever. These cases suggest that refractory diarrhea accompanied by recurrent hypoalbuminemia, especially with abdominal rash, LCH should be considered. Then gastrointestinal endoscopy, pathology and PET-CT detection need to be perfected for the definitive diagnosis. It might be helpful for the early recognition of the gastrointestinal tract involvement in LCH.
RETRACTED: What about fishery of sardine Sardina pilchardus (Walbaum, 1792) and round sardinella, Sardinella aurita (Valenciennes, 1847) in the western Mediterranean?
Authors: Dahel Amina Tania , Tahri Mardja
Published: October 2023

The authors have requested that this preprint be removed from Research Square.
A Decision Support Framework to Evaluate the Sustainability Performance of Urban Road Transportation
Authors: Babaei Ardavan , Khedmati Majid , Jokar Mohammad Reza Akbari , Tirkolaee Erfan Babaee
Published: October 2023

This study proposes a decision support framework (DSF) based on two data envelopment analysis (DEA) models in order to evaluate the urban road transportation of countries for sustainable performance management during different years. The first model considers different years independently while the second model, which is a type of network model, takes into account all the years integrated. A multi-objective programming model under two types of uncertainties is then developed to solve the proposed DEA models based on a revised multi-choice goal programming (GP) approach. The efficiency scores are measured based on the data related to several major European countries and the factors including the level of freight and passenger transportation, level of greenhouse gas emissions, level of energy consumption and road accidents which are addressed as the main evaluation factors. Eventually, the two proposed models are compared in terms of interpretation and final achievements. The results reveal that the efficiency scores of countries are different under deterministic/uncertain conditions and according to the structure of the evaluation model. Furthermore, efficiency changes are not necessarily the same as productivity changes. The high interpretability (up to 99.6%) of the models demonstrates the reliability of DSF for decision-making stakeholders in the transport sector. Furthermore, a set of managerial analyses is conducted based on different parameters of the performance evaluation measures for these countries including the productivity changes during the period under consideration, resilience of the countries, detection of the benchmark countries, ranking of different countries and detection of the patterns for improving the transportation system.
Effect and mechanism of phosphate enhanced sulfite activation with cobalt ion for effective iohexol abatement
Authors: Song Yifan , Hong Jiesheng , Shao Shujing , Wen Jiayi , Zhao Xiaodan
Published: October 2023

Sulfate radical (SO4•−) based advanced oxidation processes (AOPs) from sulfite activation has recently received attention for abatement of microorganic pollutants in the aquatic environments. Trace level Co(II) has been demonstrated to be effective for promoting sulfite activation (simplified as the Co(II)/sulfite system) and the corresponding radical formation, yet this process is challenged by the limited valence inter-transformation of Co(II)/Co(III). In order to enhance this valence inter-transformation, a novel Co(II)/HPO42−/sulfite system is developed in this work, in which complexation of Co(II) with HPO42− can regulate the electronic structure of Co(II) and promote valence inter-transformation of Co(II)/Co(III) during the sulfite activation process. The Co(II)/HPO42−/sulfite system exhibits superior iohexol abatement performance under circumneutral conditions. For pH 8.0 and Co(II) dose of 1 μM, the iohexol abatement efficiency is as high as 98%, which is considerably higher than that of the Co(II)/sulfite system (50%). SO4•− is identified as the predominant reactive radical contributing to iohexol abatement. The presence of HPO42− broadens the pH adaptability of the Co(II)/sulfite system for iohexol abatement. In addition, the coexisting Cl− exerts an inhibitory effect on iohexol abatement while the other cations and anions shows negligible effect. The Co(II)/HPO42−/sulfite system displays good reusability and adaptability towards various organic pollutants. This study highlights the important role of complexation of Co(II) with HPO42− in sulfite activation and provide a feasible idea for abatement of the microorganic pollutants.
Intestinal Metaplasia Associated with Symptoms of Dyspepsia
Authors: Viramontes Omar , Martinez Dalia , Somsouk Ma
Published: October 2023

Background
Peptic ulcer disease (PUD) and Helicobacter pylori (HP) are associated with dyspepsia, but the role of gastric intestinal metaplasia (IM) has not been described. The objective of this study is to examine the association between gastric IM and dyspepsia.
Methods
We developed a cohort of consecutive patients referred to gastroenterology between Jan 2019 and July 2020 for dyspepsia and iron deficiency anemia (IDA) and completed an upper endoscopy with biopsies in a safety-net health system. The primary outcome was the prevalence of gastric IM in patients with dyspepsia compared to IDA. Secondary outcomes included prevalence of HP, chronic gastritis (CG) and chronic active gastritis (CAG) in the dyspepsia and IDA groups. A multivariable analysis was performed to assess the independent association between gastric IM and dyspepsia
Results:
Compared to the IDA cohort (n = 366), patients with dyspepsia (n = 349) were more likely to be female (65% vs. 47%, p < 0.01), harbor gastric IM (20.3% vs. 14.2%, p = 0.03), and less likely to have CAG (12.0% vs. 26.5%, p < 0.01) or HP (10.9% vs. 21.3%, p < 0.01). After adjusting for pathological findings, race, ethnicity, gender and age, the association strengthened between IM and dyspepsia (adj OR 1.81 from OR 1.54, 95% CI 1.19–2.76, p < 0.01).
Conclusions:
We observed a significant relationship between the presence of gastric IM and dyspepsia symptoms, which increased after adjusting for confounding factors. Future studies should verify the relationship between IM and dyspepsia, the effect of IM regression, and possible mediators of gastric IM on symptoms.
Key components of educational programme to implement skin to skin contact for preterm infants in the intensive care units: An integrative literature review
Authors: Denge Takalani , Bam Nokwanda Edith , Lubbe Welma , Rakhudu Mahlasela Annah
Published: October 2023

Background
Skin to skin contact (SSC) has been embraced as an effective and efficient method of neonatal care. South Africa constitutes 60% of low birth weight (LBW) preterm infants’ mortality rate globally. This has led to a concern about the perceptions of the key drivers and parents of preterm infant regarding implementation of skin to skin contact in the intensive care units in an effort to reduce preterm mortality rate.
Objective
To critically and synthesises research-based literature on available key components of educational programme to implement SSC for preterm infants in the intensive care units.
Methods
A comprehensive search of electronic databases such as CINAHL, MEDLINE, PsycINFO, ProQuest and Health Source: Nursing/Academic Edition and Health Source-Consumer Edition using different keywords and references lists from the bibliography were searched.
Results
Twelve articles relevant to this review were identified, read and synthesised to draw the results and conclusions of the research question. Three themes emerged from the findings of this review namely: benefits of SSC, barriers to practice SSC and key components of educational programme which discussed under three subthemes (awareness and training considerations for nursing, support need of parents of preterm infants and policy and implementation regarding SSC).
Conclusions
An overview of the integrative literature review (ILR) methodology was provided. The authors of this paper have applied the described 5 steps of the integrative literature review process which was conducted as comprehensive as possible to ensure rigorous and ethical review. This paper provides key components of educational programme to implement SSC for preterm infants in the intensive care units. It also shared a lessons regarding SSC between preterm and mothers as evidenced-based practice that should be adopted optimally according to the recommendations from the World Health Organization (WHO) and other national and international organizations.
Fundamental cognizance and scholarly exploration of immune-related notions in head and neck squamous cell carcinoma (SCC) from 2012 to 2022: a bibliometric analysis
Authors: Miao Rui , Ma Wenyang , Liu Shujie
Published: October 2023

Background and Objective
Immunization holds profound research significance and promising application potential in the realm of head and neck squamous cell carcinoma (HNSCC). Regrettably, only a paucity of bibliometric data has been dedicated to a systematic examination of this domain. The present study endeavors to holistically assess the research landscape encompassing immunization and allied concepts in HNSCC. It shall encompass an exhaustive review of countries, institutions, authors, and journals involved in this sphere, while also evaluating the knowledge framework through keyword co-occurrence analysis.
Methods
The method employed for subject retrieval involved accessing the Web of Science core collection to obtain works and reviews concerning HNSCC immunity. Subsequently, bibliometric analysis was conducted utilizing the CiteSpace and VOSviewer software.
Results
Between 1 January 2012 and 31 October 2022, a total of 1,744 English works and reviews were considered in the analysis. The research contributions emanated from 402 institutions, primarily from 57 countries and regions. In terms of journals, CANCERS published the highest number of works, other journals in the fields of molecular biology, biological immunology, and clinical medicine also made substantial contributions.Over the course of time, the landscape of research hotspots gracefully evolved. Certain illustrious terms such as “open label”, “t cell”, “immunotherapy”, and “tumor microenvironment” elegantly emerged, gracing the scholarly stage with their profound frequency.
Conclusion
This study presents a thorough and all-encompassing assessment of HNSCC research within the context of immunity, achieved through the utilization of bibliometric and visualization methodologies. By offering insights into the dynamic evolution of immune-related concepts in HNSCC, this paper will undoubtedly aid researchers in gaining a deeper understanding of this complex domain.
Exosomes from adipose-derived stem cells enhance functional recovery after spinal cord injury by inhibiting ferroptosis and promoting the survival and function of endothelial cells through the Nrf2/SLC7A11/GPX4 pathway
Authors: Wu Shengting , Chen Zhiheng , Wu Yinhao , Shi Qiang , Yang Erzhu , Qian Yuxuan , Zhang Baokun , Lian Xiaofeng , Xu Jianguang
Published: October 2023

Background
Spinal cord injury (SCI) is a devastating disease that causes major motor, sensory and autonomic dysfunctions. Currently, there is a lack of effective treatment methods. In this study, we aimed to investigate the potential mechanisms of Exosomes from adipose-derived stem cells (ADSC-Exos) in reducing ferroptosis and promoting angiogenesis after spinal cord injury.
Methods
We isolated ADSC-Exos, the characteristics of which were confirmed. In vitro, we tested the potential of ADSC-Exos to promote the survival and function of human brain microvascular endothelial cells (HBMECs) with tube formation assays, scratch assays and Transwell assays and analyzed the ferroptosis of HBMECs with western blotting, immunofluorescence and biochemical detection. In vivo, we established a rat model of SCI by the modified Allen's method and locally injected ADSC-Exos to verify their efficacy.
Results
ADSC-Exos can reduce reactive oxygen species (ROS) accumulation and cell damage induced by an excessive inflammatory response in HMBECs. ADSC-Exos inhibit ferroptosis induced by excessive inflammation and upregulate the expression of glutathione peroxidase 4(GPX4) in HMBECs. It can also effectively promote proliferation, migration, and vessel-like structure formation. In vitro ADSC-Exos improved behavioral function at days 3, 7, and 14 after SCI and increased the number and density of blood vessels around the damaged spinal cord by approximately 30.4% ± 4.4%. Moreover, we found that ADSC-Exos could increase nuclear factor erythroid-2-related factor 2(Nrf2) expression and nuclear translocation, thereby affecting the expression of solute carrier family 7 member 11(SLC7A11) and GPX4, and the Nrf2 inhibitor ML385 could reverse the above changes.
Conclusion
In summary, our results suggest that ADSC-Exos may inhibit ferroptosis and promote the recovery of vascular and neural functions after SCI through the Nrf2/SLC7A11/GPX4 pathway. This may be a potential therapeutic mechanism for spinal cord injury.
A singleton pregnancy with placental chorioangioma and hydrops fetalis complicated with mirror syndrome and ritodrine-induced side effects: A case report
Authors: Wu Pei-Tzu , Huang Kun-Long , Tsai Ching-Chang , Cheng Hsin-Hsin , Lai Yun-Ju , Hsu Te-Yao
Published: October 2023

Background: Ritodrine hydrochloride is a widely used beta-adrenergic agonist used to stop preterm labor in Taiwan. Many side effects causing maternal morbidity and mortality have been reported. We report a case complicated with ritodrine-induced side effects and mirror syndrome that was associated with placental chorioangioma.Case presentation: A 36-year-old singleton pregnant woman at 25 6/7 weeks of gestation was administered continuous intravenous ritodrine for preterm uterine contractions. After one week of tocolytics, she presented with elevated serum levels of creatinine kinase (CK), acute kidney injury, impaired liver function and pulmonary edema. Ultrasound showed hydrops fetalis, polyhydramnios and placental thickening. Because of progressive dyspnea and rhabdomyolysis, emergency cesarean section was performed at 27 1/7 weeks of gestation. A 1000-g female infant with general subcutaneous edema was delivered and had an Apgar score of 1 at 1 min and 3 at 5 min. In addition, an 8.5-cm placental chorioangioma was found during the operation. After cesarean section and the cessation of intravenous ritodrine, her symptoms and laboratory indicators improved gradually during the postpartum period. It is difficult to identify mirror syndrome and ritodrine-induced pulmonary edema. Thus, this case is educational and worthy of discussion.Conclusion: Our case demonstrates mirror syndrome induced by chorioangioma, which is rare, and ritodrine-induced side effects. The cessation of intravenous ritodrine and delivery are the best methods to treat maternal critical status due to fluid overload.
Correlation between the times of IUI and pregnancy outcome: a systematic review and meta-analysis with trial sequential analysis of cohort study
Authors: Yu Wenjing , Wei Aiwu , Yuan Hao , Sun Zhiyu
Published: October 2023

Purpose
the study aims to evaluate whether increasing the times of IUI per cycle has better pregnancy outcomes for infertile couples.
Methods
PubMed, Embase, Web of science, Cochrane Library, CNKI, WanFang Data, VIP (VIP Chinese Journal Service Platform), and SinoMed (China Biomedical Literature Service), were systematically retrieved cohort studies about the times of IUI per cycle and pregnancy outcomes published before December 31, 2021. Included studies were assessed by Newcastle-Ottawa Scale (NOS) with two reviewers. The data was processed with RevMan 5.4.1 and the result of the meta-analysis were further examined by TSA 0.9.5.10 Beta version.
Results
23 cohort studies with 54208 IUI cycles were included in this study. Meta-analysis of the data reported in these 23 studies showed that the cycle pregnancy rates were higher in the double insemination group (double IUI) than in the single insemination group (single IUI) [RR = 1.14, 95% CI (1.02, 1.27), I2 = 64%, P = 0.02]. Sensitivity analysis showed that the results were stable and reliable. The bias analysis showed that there was a low possibility of publication bias in this study. TSA of 23 trials illustrate that the cumulative z-curve crossed the traditional boundary, the trial sequential monitoring boundary and the required information size(RIS).
Conclusion
compared with single IUI, double IUI per cycle can increase the cycle pregnancy rates to a small extent without increasing the incidence of biochemical pregnancy, miscarriage, or ectopic pregnancy. The results should be treated with caution and other factors should be taken into consideration when making clinical decisions.
Study Protocol: A pragmatic, cluster-randomized controlled trial to evaluate the effect of implementation of the Truenat platform/MTB assays at primary health care clinics in Mozambique and Tanzania (TB-CAPT CORE)
Authors: Leukes Vinzeigh Nicholas , Riess Friedrich , Erkosar Berra , Ntinginya Nyanda Elias , Sabi Issa , Mangu Chacha , Siyame Elimina , Mtafya Bariki , Lwilla Anange , Khosa Celso , Viegas Sofia , Madeira Carla , Machiana Antonio , Ribeiro Jorge , Garcia-Basteiro Alberto , Nguenha Dinis , Cossa Marta , Elisio Delio , Hella Jerry , Sasamalo Mohamed , Mhalu Grace , Denkinger Claudia Maria , Castro Maria del Mar , Schumacher Samuel , Tagliani Elisa , Malhotra Akash , Dowdy David , Bashir Saima , Schact Claudia , Buech Julia , Ruhwald Morten , Penn-Nicholson Adam , Kranzer Katharina
Published: October 2023

Background
In 2020, the WHO-approved Molbio Truenat platform and MTB assays to detect Mycobacterium tuberculosis complex (MTB) and resistance to rifampicin directly on sputum specimens. This primary health care center-based trial in Mozambique and Tanzania investigates the effect of Truenat platform/MTB assays (intervention arm) combined with rapid communication of results compared to standard of care on TB diagnosis and treatment initiation for microbiologically confirmed TB at 7 days from enrolment.
Methods
The Tuberculosis Close the Gap, Increase Access, and Provide Adequate Therapy (TB-CAPT) CORE trial employs a pragmatic cluster randomized controlled design toevaluate the impact of a streamlined strategy for delivery of Truenat platform/MTB assays testingat primary health centers. Twenty-nine centers equipped with TB microscopy units were selected to participate in the trial. Among them, fifteen health centers were randomized to the intervention arm (which involves onsite molecular testing using Truenat platform/MTB assays, process process optimization to enable same-day TB diagnosis and treatment initiation, and feedback on Molbio platform performance) or the control arm (which follows routine care, including on-site sputum smear microscopy and the referral of sputum samples to off-site Xpert testing sites). The primary outcome of the study is the absolute number and proportion of participants with TB microbiological confirmation starting TB treatment within 7 days of their first visit. Secondary outcomes include time to bacteriological confirmation, health outcomes up to 60 days from first visit, as well as user preferences, direct ccost,and productivity analyses.
Ethics and dissemination
TB-CAPT CORE trial has been approved by regulatory and ethical committees in Mozambique and Tanzania, as well as by each partner organization. Consent is informed and voluntary, and confidentiality of participants is maintained throughout. Study findings will be presented at scientific conferences and published in peer-reviewed international journals.
Trial Registration
US National Institutes of Health’s ClinicalTrials.gov, NCT04568954. Registered 23 September 2020.
Proportions and risk factors of chronic obstructive pulmonary disease and preserved ratio impaired spirometry, and association with small airway disease, in the screening positive older population from china: a cross-sectional study
Authors: Sang Le , Gong Xia , Huang Yunlei , Sun Jian
Published: October 2023

Background Early diagnosing Chronic Obstructive Pulmonary Disease (COPD) is relatively difficult. Therefore, the concepts of preserved ratio impaired spirometry (PRISm) and small airway disease (SAD) were proposed, expecting to achieve early diagnosis for COPD. Besides, the occurrence of COPD is positively related to age. However, the relation among COPD, PRISm, and SAD still requires clarification. Thus, we estimated the proportions and risk factors of COPD and PRISm in the screening positive participants, and searched the methods of early diagnosing COPD through the indicators of SAD. Methods A total of 53641 residents aged more than 60 years old from Shaoxing City, Zhejiang Province, China, completed a series of screening projects. And 2327 of screening positive participants ultimately finished bronchodilator tests. The data were statistically analyzed to figure out the proportions and risk factors of COPD and PRISm, and the efficacy of early diagnosing COPD by the indicators of SAD. Results Totally 2229 screening positive participants were included, the proportion of PRISm was 6.3% (141/2229), and of COPD was 78.2% (1743/2229). The results of statistical analysis showed that COPD patients were more likely to be smokers, males, older, and with higher questionnaire scores. Additionally, COPD patients had lower maximal mid-expiratory flow (MMEF), forced expiratory flow (FEF)75pred, and FEF50pred. And it was found that male sex and the presence of respiratory symptoms might lead to COPD and PRISm. Also, the methods of early diagnosing COPD by the indicators of SAD might be acceptable. Conclusion There is a close relation between COPD and decreased small airway function (SAF) among the participants included. Age, smoking, male sex, worse SAF, and respiratory symptoms might cause the progressing from normal people to PRISm, then to COPD patients. Besides, early diagnosing COPD by the indicators of SAD might be feasible. In the future, early diagnosis for COPD requires further research.