bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALISA ROI DENGAN PENDEKATAN DU PONT DALAM MENILAI KINERJA KEUANGAN PT. MUSTIKA RATU, TBK DSN PT. MARTINA BERTO TAHUN 2010 - 2016
Authors: Nuriasari Selvia
Published: September 2019

Rasio Profitabilitas adalh rasio yang melihat kemampuan perusahaan menghasilkan laba, salah satu rasionya adalah rasio ROI du pont. Tujuannya adalah agar mampu melihat lebih detail tentang penyebab kenaikan atau penurunan dari ROI itu sendiri. PT. Mustika Ratu, Tbk dan PT. Martina Berto adalah dua perusahaan nasional yang bergerak di sektor industri manufaktur yang kondisi ekonomi perusahaan tersebut mengalami penurunan yang disebabkan antara lain masuknya produk – produk dari luar negeri. Tentunya ini akan berdampak pada penurunan penjualan dan ada indikasi persediaan yang menumpuk akibat dari turunnya penjualan.

 Profitability Ratio is the ratio that sees the company's ability to generate profit, one of which is the ratio of ROI du pont. The goal is to be able to see more detail about the cause of the increase or decrease of the ROI itself. PT. Mustika Ratu, Tbk and PT. Martina Berto is two national companies engaged in the manufacturing industry that the company's economic conditions experienced a decrease caused by the entry of products - products from abroad. Surely this will have an impact on sales declines and there are indications of inventories that accumulate as a result of declining sales.
MERETAS URGENSI AUDIT KINERJA DALAM MENCIPTAKAN AKUNTABILITAS KINERJA INSTANSI PEMERINTAH KOTA/KABUPATEN
Authors: Sugimin Sugimin
Published: September 2019

This article explains the urgency of an audits performance (value for money audits) in creating of performance accountability at cityor district government instance. This study was conducted by literature study with reference to a number of previous study and related regulations. The results of the study indicate that performance is a formal evaluation instrument for the government program. It helps to increase the public accountability by providing information concerning the government performance that may not be accessible to the public. The understanding of this concept and its implementation will enable to achieve optimal accountability for the public sector. It is concerned about performance audits centered on economic achievement, efficiency, and effectiveness depend on the existence of regulation, planning, assessment, authorization and control over the use of its resources. It is the responsibility of the public policy makers to establish the arrangements and to ensure that they are functioning appropriately. The responsibility of the internal auditor is to independently verify that execution of activities by policymakers have complied with the basic standards.
PEMBATALAN UANG MUKA DALAM PERJANJIAN PESANAN MENURUT HUKUM EKONOMI SYARIAH (Studi Kasus pada Mebel Jati Ukir Sumber Anugrah Metro Utara)
Authors: Zulaikha Siti
Published: September 2019

Buying and selling is one form of activity that involves the relationship between humans to meet their daily needs. The problems that occur in the order agreement in Mebel Jati Ukir Sumber Anugrah Metro Utara are the practice of applying advances in order agreements and how the views of sharia economic law apply to the cancellation of advances in order agreements. The purpose of this study is to find out how to apply advances in agreements order and know how the views of sharia economic law on the application of advances in the agreement of orders for Mebel Jati Ukir Sumber Anugrah Metro Utara. The benefit of this study is to be able to add to the scientific repertoire in the field of muam especially regarding the views of sharia economic law on the application of advances in order agreements and as input for the people who make order agreements to pay attention to Islamic economic law provisions so that no party is harmed. This study uses a type of field research research with the nature of qualitative descriptive research. Data sources used are primary data sources and secondary data sources. The data obtained were analyzed using qualitative analysis methods namely inductive methods. Based on the research it can be concluded that the application of advances in the order agreement in teak Mebel Jati Ukir Sumber Anugrah Metro Utara according to Sharia Economic Law is permissible. This is because the furniture owner has provided a period of time for the buyer to settle the remaining payment. So that if the buyer cannot pay off the remaining payment before maturity, then the advance that has been given belongs to the furniture.
Hubungan Pembelajaran Akidah Akhlak Dengan Perkembangan Akhlak Remaja di Solihuddin School, Chana Thailand
Authors: Baisa Hidayah
Published: September 2019

This article discusses the phenomenon of matters of adolescent morality that is very apprehensive in the global era. Teenagers seem to have escaped from the intrinsic values ​​of religion as the benefit of the people’s life. Aqidah akhlaq education has become a curriculum in schools, students are expected to grow and improve their faith; through attitude and praiseworthy behavior. In addition, students are also expected to achieve balance material and spiritual, alignment of the relationship between humans in the social sphere of society and the environment, also especially strengthen human relationships with God. This paper intends to know the relationship of aqidah akhlak with the development of morals in Solihuddin School, Chana Thailand. How is the implementation of moral aids in Solihuddin School Chana Thailand ?; And how is the development of morality in the environment of Solihuddin School Chana, Tahiland? And how is the relationship between the learning of moral character and the development of morals in Solihuddin School Chana Thailand? The research was conducted at Solihuddin School, Chana Thailand. The data obtained through observation, interviews, documentation and questionnaire given to 30 students as sample or 30% of the total population of 103 students. From the research, it can be concluded that the implementation of aqidah akhlak teaching has significant relationship with the development of morality in adolescent at Solihuddin School, Chana Thailand.
GLOBALISAI MELAYU: Peluang dan Tantangan Membangun Identitas Melayu dalam Konteks Modernitas
Authors: Sanusi Ihsan
Published: September 2019

This article discusses Malay globalization. Actually, what the Malays call is not an ethnic or ethnic community as many people today understand. It is time for Malays to collectively refine their view of Malay by building a different paradigm in a horizontal level through a not-cramped perspective of lokaism, since Malay is something that is not single (heterogeneous). In the identification and revitalization of Malay it is actually needed support from various components, both intellectuals and experts, as well as the holders and policy makers in several Malay rural countries. Thus expected the birth of a kind of strategic alliance between Malays in order to develop science and technology, politics, economics, culture, education and others. In any case, in the context of the modernity of Malay civilization that has found its identity will become more advanced as well as will be able to influence the great civilization of the world-if it can reverse the state of the hegemony into a hegemonizing culture.
PENDIDIKAN DAN BIMBINGAN KECAKAPAN HIDUP (LIFE SKILL) PESERTA DIDIK
Authors: Mislaini Mislaini
Published: September 2019

Education must reflect the values ​​of everyday life, both preservative and progressive. So that educational institutions should merge with real-life values ​​that exist in the environment. For this reason life skill education (life skill) undoubtedly to be applied and applied for students in any educational institutions tingakat. The development of life skills values ​​in various activities in educational institutions both in classroom learning, as well as in extracurricular activities, and in religious activities is expected to foster unyielding spirit with high work ethic, creative independence, innovative in creating works in all Field, so that in the end able to create human resources that qualified for the surrounding community.
PENGARUH PENERAPAN MODEL CONTROVERSIAL ISSUES (CI) TERHADAP PENINGKATAN KETERAMPILAN SOSIAL DAN HASIL BELAJAR SISWA YANG RESPONSIF GENDER
Authors: Cahyo Edo Dwi
Published: September 2019

The purpose of this study was to determine the improvement of social skills and gender responsive students after the implementation of the Controversial Issues (CI) model in social studies learning while at the same time looking at student learning outcomes. The method of this research is the quasi-experimental method using the nonequivalent groups pretest-posttest design. The population is the fourth grade students of SD Negeri 8 Metro Timur with samples of classes IV A and IV B. Data collection techniques are in the form of tests and sets of students' social skills. The results of this study indicate that the Controversial Issues (CI) model in social studies learning can improve social skills and gender-responsive student learning outcomes.
PENGARUH PERILAKU NARSIS DAN SELF-ESTEEM TERHADAP PENGENDALIAN DIRI AKUNTAN DALAM BERINTERAKSI DI MEDIA SOSIAL DENGAN ETIKA PROFESI AKUNTAN SEBAGAI VARIABEL INTERVENING
Authors: Nurbaeti Nurbaeti
Published: September 2019

This research is conducted to investigate the effect of narcissism and self-esteem toward the accountantsâ€™ self control in the interaction in social media with accountant professional ethics as an intervening variabel. The method of the research used is causality-explanatory to analyze as well as to prove that ther is a correlation among two or more variables. The object of this research are 100 people as respondents, they are educators, auditors and accountants in some companies in Tangerang and Jakarta. The technique used in taking samples is purposive sampling. This research used Narcissistic Personality Inventory (NPI-16), Rosenberg Self-Esteem Ten Scales, Accountants professional ethics and accountants self control scale. The method of data analaysis used is Path Analysis. The data that the researcher got has meet the prerequisite to do the test of data quality and classic assumption. The series of data analysis using SPSS version 23 got that narcissism and self-esteem affect the accountants professional ethics simultaneously and significantly, while self-esteem significantly affects the professional ethics of accountants. Narcissism, self-esteem and accountant professional ethics affect simultaneously toward accountantsâ€™ self control, narcissism doesâ€™nt effect significantly toward accountantsâ€™ self control and accountants professional ethics  affects significantly toward their self control. The determination coefficient shows 10,3% of accountantsâ€™ self control variable affected by their narcissism, self-esteem and their ethics, while the rest 89,7% affected by other factors.
SHARIA COMPLIANCE, SHARIA GOVERNANCE, AND ENVIRONMENTAL ACCOUNTING SEBAGAI PERTANGGUNGJAWABAN LEMBAGA AMIL ZAKAT DI INDONESIA
Authors: Azmi Fika , Widiarto Ardian , Pramono Nugroho Heri
Published: September 2019

Penelitian ini bertujuan untuk mengetahui pengaruh sikap dan kepercayaan akuntan sert manajer terhadap minat dalam mengungkapkan sharia compliance, sharia governace, dan environmental accounting. Sampel yang digunakan dalam penelitian ini adalah 30 data pengamatan pada akuntan dan manajer lembaga amil zakat yang ada di Indonesia. Teknik pengambilan sampel yang digunakan adalah dengan menggunakan simple random sampling. Hasil penelitian menunjukkan bahwa secara simultan variabel sikap dan kepercayaan akuntan serta manajer berpengaruh terhadap minat dalam mengungkapkan sharia compliance, sharia governace, dan environmental accounting. Sedangkan secara parsial sikap dan kepercayaan tidak berpengaruh terhadap minat akuntan dan manajer dalam mengungkapkan sharia compliance, sharia governace, dan environmental accounting.
EFEKTIVITAS PERMOHONAN PRAPRADILAN DALAM UPAYA HUKUM TERHADAP PENETAPAN TERSANGKA
Authors: Waldo Risky
Published: September 2019

Dasar kewenangan pengadilan memeriksa dan memutus gugatan praperadilan tentang tidak sahnya penetapan tersangka sebagaimana ketentuan pasal 77 Undang Undang Republik Indonesia Nomor 8 Tahun 1981 Tentang KUHAP pada putusan Nomor 09/Pid.Pra/2015/PN.Jak.Bar). Penelitian ini bertujuan untuk mengetahui Efektivitas Permohonan prapradilan upaya hukum terhadap penetapan tersangka; dan Hambatan-hambatan dalam pelaksanaan Praperadilan pada perkara (No.09/Pid.Prap/2015/PN. Jak.bar). Metode penelitian yuridis normatif dengan pendekatan kajian literatur dianalisis dengan normatif kualitatif. Hasil penelitian menunjukan Pertama, upaya hukum prapradilan cukup efektif dalam melindungi hak tersangka karena mempunyai kekuatan hukum mengikat; Kedua, hambatan yang dihadapi justifikasi masyarakat terhadap hakim pemutus dan teknis berperkara yang tidak konsisten dalam penerapannya.
PENERAPAN SANKSI PIDANA TERHADAP PELAKU TINDAK PIDANA PERZINAHAN
Authors: Kartono Kartono
Published: September 2019

Perbuatan persetubuhan dalam KUHP termasuk kategori kejahatan terhadap kesusilaan yaitu salah satu kejahatan yang dikenal dengan perzinahan atau mukah (overspel). Penelitian ini bertujuan untuk mengetahui dan menganalisa bagaimana Hakim mempertimbangkan dasar-dasar hukum materiil dalam putusan Nomor: 1952/Pid.B/2014/PN.TNG menerapkan dakwaan Pasal 284 ayat 1 ke-1, dan hakim dalam memutus perkara perzinahan Nomor 1952/Pid.B/2014/PN.TNG terkait pasal 27 BW, sudah tepat dalam penerapannya. Metode penelitian yuridis normatif berdasarkan data kepustakaan yang dianalisis secara normatif kualitatif. Hasil penelitian menunjukan unsur-unsur tindak pidana perzinahan dalam putusan ini telah terpenuhi dan penerapan pasal 284 ayat 1 yang dijadikan dasar hukum pertimbangan hakim kurang tepat karena salah satu terdakwa tidak tunduk pada pasal 27 BW mengingat di dalam ayat 5 Pasal 284 harus adanya putusan cerai terlebih dahulu. Hakim dalam menjatuhkan pidana terhadap pelaku perzinahan perkara Nomor: 1952/Pid.B/2014/PN.TNG lebih didasarkan pertimbangan dari sisi psikologis terdakwa untuk perbaikan diri, hal ini terlihat dalam pemberian hukuman didasarkan unsur Pasal 284 ayat (1) ke-1 huruf a KUHP tidak terpenuhi sehingga unsur Pasal kabur dan dipaksakan.
CYBERLOAFING SEBAGAI STRATEGI MENGATASI KEBOSANAN KERJA
Authors: Azizah Siti Nur , Setyawati Harini Abrilia
Published: September 2019

Cyberloafing has been considered as a form of opposite / unproductive work behavior (CWB) that can endanger organizations. This study takes a different view that cyberloafing can show a potentially positive function in this context that can help employees overcome boredom at work. The sample of this study was 70 administrative employees at junior high schools in Kebumen which were taken randomly. By using PLS assistance we tested the relationship between low work underload on cyberloafing and counter-productive behavior with boredom as mediators. The results of the study indicate boredom mediates the work underload and cyberloafing relationship. Cyberloafing is used by employees as a coping strategy (adaptive behavior) to overcome work boredom compared to counter-productive behavior  

Keywords: Cyberloafing, work underload, kebosanan, counter productive work behavior(CWB)
STRATEGI PEMBERDAYAAN KEWIRAUSAHAAN MANTAN BURUH MIGRAN PEREMPUAN DI KABUPATEN KEBUMEN
Authors: Fitra Joko , Rizana Dani
Published: September 2019

This study examines the entrepreneurial empowerment strategy of former female migrant workers who are members of the Village community concerned with Migrant Workers. After returning from work abroad, former female migrant workers again experienced an economic downturn, making it difficult to meet basic family needs. This study aims to determine the economic conditions of former female migrant workers after returning, strategies for fulfilling post-return life needs, and entrepreneurial empowerment strategies carried out by various institutions.

This research approach uses a descriptive qualitative approach. Data collection techniques using observation techniques, in-depth interview techniques, and library studies and documentation. Taking informants is done by using informant techniques aimed at. Data analysis used the Miles and Huberman analysis model which consisted of data collection, data reduction, data presentation, and conclusion drawing.

The results showed that the entrepreneurial empowerment process of former female migrant workers was carried out because there were indications of weakening economic conditions after stopping work abroad. The goal of empowering former migrant workers is to alleviate economic weakness because it is seen that it still has the potential to be able to regain power in meeting economic needs. The empowerment process carried out by cross institutions is well integrated, where each institution coordinates with each other to complement each other's empowerment programs. The synergy of entrepreneurial empowerment carried out on former female migrant workers in Kebumen District has resulted in improved capabilities such as operating business activities, completing business licenses, increasing production capacity, expanding market reach, networking with other communities, increasing turnover and profits, and continuously being encouraged to develop.Keywords: Empowerment, Former Female Migrant Workers, Entrepreneurship
Quality of Snap Bean (Phaseolus Vulgaris L.) as influenced by N and P Fertilizer Rates at Jimma Southwestern Ethiopia
Authors: Negash Abdela , Getachew Essubalew
Published: September 2019

Snap bean is a warm-season crop harvested for its immature seed pods. In Ethiopia its production increased from time to time for both export and local markets. A field experiment was conducted at the research field of JUCAVM, during 2017 cropping season using irrigation aiming to improve the quality of snap bean. Five levels of N (0, 41, 82, 123, and 164 kg ha−1) and four levels of P (0, 46, 92 and 138 kg ha−1) were laid down in a randomized complete block design with three replications. N was applied in two equal splits (50% at planting and 50% during flowering) as Urea and the entire dose of P was applied basal as triple super phosphate at sowing. In this experiment pod length, pod diameter, pod protein concentration, pod straightness and marketable pod yield were measured as quality parameters. The results revealed that the main effects of N and P fertilizer rates showed significant differences (P ≤ 0.05) for all quality parameters except for percentage of pod protein concentration and straightness of pod. Accordingly, the interaction effects of N and P were significant for percent of pod protein concentration and straightness of pod. Considering the major quality parameters and marketable pod yield applying 82 kg N ha −1 and 46 kg P2O5 ha−1 gave better result to increase the quality of snap bean in Jimma area. However, repeating the experiment for more seasons and similar location would help us draw sound conclusion and recommendations.
PENGARUH PEMBERIAN JUS BUAH BELIMBING WULUH (AVERRHOA BILIMBI L.) TERHADAP KADAR TRIGLISERIDA DARAH TIKUS PUTIH (RATTUS NORVEGICUS) JANTAN GALUR WISTAR YANG DIBERI DIET TINGGI LEMAK
Authors: Fatichasari Hilda Dwi
Published: September 2019

ABSTRAK

Latar Belakang: Hipertrigliseridemia merupakan suatu keadaan yang terjadi karena  peningkatan kadar trigliserida ≥150 mg/dl. Pencegahan hipertrigliseridemia sangat diperlukan secara non farmakologi dengan mengubah gaya hidup sehari – hari, apabila hal ini tidak berhasil dibutuhkan farmakoterapi menggunakan obat konvensional dan atau obat tradisional. Salah satu obat tradisional yang secara empiris digunakan untuk menurunkan trigliserida adalah buah belimbing wuluh (Averrhoa bilimbi L.).

Tujuan: Tujuan penelitian untuk menilai efek pemberian jus buah belimbing wuluh terhadap kadar trigliserida tikus Wistar jantan.

Metode: Desain penelitian eksperimental laboratorik. Hewan coba 24 ekor tikus Wistar jantan, dibagi secara acak kedalam 3 kelompok (n=8). Kelompok kontrol negatif hanya diberikan pakan biasa. Kelompok kontrol positif diberikan pakan tinggi lemak selama 28 hari. Kelompok perlakuan diberikan pakan tinggi lemak 28 hari dan jus buah belimbing wuluh dengan dosis 4ml/200grBB pada hari ke 15 selama 14 hari. Analisis data persentase penurunan kadar trigliserida menggunakan One-Way ANOVA, yang dilanjutkan uji Post Hoc dengan teknik LSD.

Hasil: Pada kelompok kontrol negatif menunjukkan rerata kadar trigliserida sebesar 66,13 mg/dl. Sedangkan pada kelompok kontrol positif, hasil penelitian menunjukkan adanya peningkatan rerata kadar trigliserida sebesar 96,13 mg/dl. Pada data penelitian didapatkan nilai p = 0,048 (p < 0,05), sehingga dapat disimpulkan bahwa terdapat kenaikan kadar trigliserida yang bermakna. Kenaikan ini menunjukkan bahwa diet tinggi lemak dapat meningkatkan kadar trigliserida darah.

Kesimpulan: Jus Buah Belimbing Wuluh dapat menurunkan kadar trigliserida namun tidak signifikan secara statistik.

Kata Kunci: Trigliserida, diet tinggi lemak, Belimbing wuluh (Averrhoa bilimbi L.)
Realism in the Trans ASEAN Gas Pipeline Project
Authors: Syah Rahmadha Akbar , Mahmud Zaki Khudzaifi
Published: September 2019

To improve connectivity and energy security, especially natural gas, Southeast Asian countries, under the cooperation of Association of Southeast Asian Nations (ASEAN), are trying to build a gas pipeline that stretches from Indonesia to Myanmar. The project is called the Trans ASEAN Gas Pipeline (TAGP) under the ASEAN Plan of Action for Energy Cooperation (APAEC) scheme. However, regional countries are still dealing with their domestic problems, and there are fears that TAGP is detrimental to producer countries, resulting in the delay of this project as much by as four years – from 2020 to 2024. The uncertainty of the TAGP project further emphasizes that there is a tendency for countries not to adhere to the ASEAN forum’s agreements. Especially if it has to be juxtaposed with the Russian Gas Pipeline project which was built to distribute natural gas to Western European countries, TAGP is still far behind. In designing this paper, the authors use qualitative methods through literature studies by referring to the realism approach of International Relations to dissect TAGP problems. Furthermore, the author also feels the need to accommodate the neorealism approach to be used as a supportive approach in looking at the issues of disobedience in regional countries in supporting the TAGP scheme. Also, the authors conducted a brief comparison between TAGP and the Russian Gas Pipeline to be used as a case study analysis material that would later provide answers of why TAGP failed to go as planned.Keywords: realism, neorealism, TAGP, Russian Gas Pipeline
Pengembangan Matriks antar Standar Nasional Pendidikan Tinggi, Akreditasi Perguruan Tinggi dan Akreditasi Program Studi
Authors: Hakim Achmad Lukman
Published: September 2019

Urgensi pengembangan sistem akreditasi nasional adalah untuk merespon dan mengantisipasi perubahan internal dan eksternal yang terkait dengan dunia pendidikan tinggi. Tujuan penelitian ini adalah untuk mengembangkan matriks ke asosiasi antar standar nasional pendidikan tinggi, akreditasi perguruan tinggi dan akreditasi program studi. Jenis penelitian ini kualitatif dengan penelitian dan pengembangan. Informan penelitian ini adalah kepala Penjaminan Mutu, Wakil Katua I STIKIM serta orang yang ahli di bidang standar pendidikan tinggi. Penelitian ini dilakukan pada bulan Februari – Maret 2019 di Sekolah Tinggi Ilmu Kesehatan Indonesia Maju Jakarta. Pengembangan standar dilakukan dengan melihat aspek ketersediaan, yakni STIKIM saat ini telah mengambangkan yang awalnya tersedia 25 standar menjadi 30 standar. Berdasarkan aspek kecukupan, hasil studi literatur yang peneliti lakukan, 30 standar yang dikembangkan STIKIM sudah mencakup standar minimum dalam penilaian instrumen akreditasi perguruan tinggi 3.0 dan telah disesuaikan dengan penilaian instrumen akreditasi program studi 4.0. Berdasarkan aspek kemutakhiran, pernyataan standar yang dikembangkan sudah ditingkatkan selaras dengan matriks penilaian akreditasi institusi 3.0 dan akreditasi program studi 4.0. Diharapkan STIKIM dalam membuat program kerja menyesuaikan standar yang telah ditetapkan, yaitu pada indikator kinerja STIKIM.
A Study on Deformation of Land and Loss of Vegetation Due to Mining at Barapukuria Coal Mine
Authors: Abedin I. , Abir M. A. N. , Hussain A. , Hasan G.
Published: September 2019

Barapukuria coal mine is the biggest coal mine in Bangladesh discovered in 1985. It has lease area around 10.53 square km with the total reserve of 390 million tons. Though it fulfils the major portion of demand of coal in Bangladesh nevertheless it has severe effect like deformation of topography of that surface area while extracting coal from mine and causes severe impact on vegetation on the coal mine vicinity. This is due to some poor design of extraction process. The intent and purpose of this research is to make an analysis of the influence of topography changes due to mining and impact on vegetation. To assess the effect of mining on vegetation and topography remote sensing technology, GIS and Landsat image were used. Our study confirms the deformation of topography and loss of vegetation due to mining. If this mining process continue it will create adverse effect on environment. The result is expected to be a reference for various parties to perform activities related to the mining of coal in Barapukuria coal mine.
Comparative Dermatoglyphic Study Between Schizophrenic Patients and Healthy Controls
Authors: Mustafa Rashed , Afroze Akhtari , Sobnom Sabrina , Hossain Abdullah Al Mamun , Ahmed Md Shameem , Haque AQM Ataul
Published: September 2019

Introduction: Dermatoglyphics is the branch of medical science that is concerned with the study of dermal ridges present on fingers, palms, toes and the soles of the human being. There may have some association between fingerprints and schizophrenia regarding the developmental background of skin ridge pattern and brain.So this study was conducted to find out the fingerprint patterns in schizophrenic patients and also to find out sex variation of fingerprint patterns in between schizophrenic male and schizophrenic female.

Objective: This study was carried out with a view to find out the fingerprint patterns in schizophrenic patients.

Methodology: A total of 200 samples were selected. Among them, 100 were schizophrenic and 100 were normal healthy control. Samples were taken in between 15 to 40 years of age. Selection of schizophrenic sample was performed by a qualified psychiatrist. Fingerprints were taken by Ink and pad method, described by Cummins. Fingerprint patterns were observed by using a magnifying glass.

Results: The frequency of common fingerprint pattern was reduced in schizophrenia. In healthy control loop pattern was predominant. But in schizophrenia frequency of loop pattern was reduced and there was an increased frequency of whorl and arch pattern.

Conclusion: Asdermatoglyphics is genetically determined, predominant whorl and arch pattern found among the schizophrenic patients might provide a presumptive value which would aid in diagnosis of the disease.

KYAMC Journal Vol. 10, No.-2, July 2019, Page 66-72
Advantages of Modified Computed Tomography Severity Index of Acute Pancreatitis Over Other Scoring System
Authors: Sharif Md Mofazzal , Rekha Khaleda Parvin , Siddiqua Umme Iffat , Khatun Mst Monira , Haque AKM Enamul , Arifin Saiful
Published: September 2019

Pancreatitis is one of most complex and clinically challenging of all abdominal disorders. USG and abdominal Computed Tomography (CT) are the most commonly used diagnostic imaging modalities for the evaluation of pancreas. Computed Tomography (CT) is highly accurate and sensitive than USG in both diagnosing as well as demonstrating the extent. Early assessment of the cause and severity of acute pancreatitis is of utmost importance for prompt treatment and close monitoring of patient with severe disease. CT is the imaging method of choice for assessing the extent of acute pancreatitis and for evaluating complications. CT severity index is used to assess prognostic correlation and clinical outcome of acute pancreatitis. Modified CT severity index makes the score easier to calculate and reduces the inter-observer variation.

KYAMC Journal Vol. 10, No.-2, July 2019, Page 110-113
Supracardiac Total Anomalous Pulmonary Venous Connection
Authors: Islam ASM Shariful , Rahman Md Lutfar , Saha Jayanta Kumar , Rahman Mohammad Arifur , Rahman Mezanur , Munshi Prakash Chandra , Tamal Taslim Yusuf
Published: September 2019

Total anomalous pulmonary venous connection (TAPVC) is a rare congenital heart disease in which there is developmental absence of connection of all four pulmonary veins with the left atrium. To report a rare case and share our experience in surgery and post-operative management for supracardiac TAPVC. Patient with supracardiac TAPVC with atrial septal defect (ASD) secundum variety with rudimentary patent ductus arteriosus (PDA) underwent rechanneling of pulmonary veins to left atrium (LA) with gluteryldehye treated autologous pericardial patch closure of ASD with ligation of ascending vertical vein and ligation of rudimentary PDA.Post operatively there were no events of pulmonary hypertensive crisis, low cardiac output syndrome, right heart failure or conduction defect were observed and echocardiogram showed adequate pulmonary venous drainage with no residual shunt across the interatrial septum. Marked development in surgical results of TAPVC has been observed in recent years with declining mortality rate from 65% in early sixties to 5% in current surgical scenerio.

KYAMC Journal Vol. 10, No.-2, July 2019, Page 118-121
Model-Based Fault Detection and Identification for Prognostics of Electromechanical Actuators Using Genetic Algorithms
Authors: Dalla Vedova Matteo D. L. , Germanà Alfio , Berri Pier Carlo , Maggiore Paolo
Published: September 2019

Traditional hydraulic servomechanisms for aircraft control surfaces are being gradually replaced by newer technologies, such as Electro-Mechanical Actuators (EMAs). Since field data about reliability of EMAs are not available due to their recent adoption, their failure modes are not fully understood yet; therefore, an effective prognostic tool could help detect incipient failures of the flight control system, in order to properly schedule maintenance interventions and replacement of the actuators. A twofold benefit would be achieved: Safety would be improved by avoiding the aircraft to fly with damaged components, and replacement of still functional components would be prevented, reducing maintenance costs. However, EMA prognostic presents a challenge due to the complexity and to the multi-disciplinary nature of the monitored systems. We propose a model-based fault detection and isolation (FDI) method, employing a Genetic Algorithm (GA) to identify failure precursors before the performance of the system starts being compromised. Four different failure modes are considered: dry friction, backlash, partial coil short circuit, and controller gain drift. The method presented in this work is able to deal with the challenge leveraging the system design knowledge in a more effective way than data-driven strategies, and requires less experimental data. To test the proposed tool, a simulated test rig was developed. Two numerical models of the EMA were implemented with different level of detail: A high fidelity model provided the data of the faulty actuator to be analyzed, while a simpler one, computationally lighter but accurate enough to simulate the considered fault modes, was executed iteratively by the GA. The results showed good robustness and precision, allowing the early identification of a system malfunctioning with few false positives or missed failures.
Abundant Genetic Diversity of Yunling Cattle Based on Mitochondrial Genome
Authors: Xia Xiaoting , Qu Kaixing , Li Fangyu , Jia Peng , Chen Qiuming , Chen Ningbo , Zhang Jicai , Chen Hong , Huang Bizhi , Lei Chuzhao
Published: September 2019

Yunling cattle are a composite beef cattle breed, combining Brahman (1/2), Murray Grey (1/4) and Local Yunnan cattle (1/4), that was developed in Yunnan, China in the 1980s. Understanding the genetic information of Yunling cattle is of great significance to the development of reasonable breeding strategies for this breed. In the present study, we assessed the current genetic status of Yunling cattle in Yunnan Province (China) by analyzing the variability of the whole mitochondrial genome of 129 individuals. Altogether, 129 sequences displayed 47 different haplotypes. The haplotype diversity and the average number of nucleotide differences were 0.964 and 128.074, respectively. Phylogenetic analyses classified Yunling cattle into seven haplogroups: T1, T2, T3, T4, T6, I1 and I2. Haplogroup I1 was found to be predominant (41.86%), followed by T3 (28.68%). Furthermore, we also identified a novel haplogroup, T6, and defined the sub-haplogroup I1a in Yunling cattle. According to the formation process of Yunling cattle (local Yunnan cattle as the maternal line), the high genetic diversities in the mitochondria of Yunling cattle could be due to the complex maternal origin of local Yunnan cattle. Further studies about local Yunnan breeds are necessary to determine the exact source of haplogroup T6 in Yunling cattle. Our results will be useful for the evaluation and effective management of Yunling cattle.
Female Asthmatic Patients Have Higher Risk to Develop Gemifloxacin-Associated Skin Rash, Highlighting Unique Delayed Onset Characteristics
Authors: Wu Chiou-Mei , Wei Po-Ju , Shen Yu-Ting , Chang Hsu-Liang , Tsai Ying-Ming , Pan Hung-Fang , Chang Yong-Chieh , Wei Yu-Ching , Yang Chih-Jen
Published: September 2019

Gemifloxacin is a common oral antibiotic for lower respiratory tract infection worldwide. We noticed an uncommon delayed onset skin rash in patients who received Gemifloxacin. Therefore, we retrospectively reviewed all patients who received Gemifloxacin from 1 January 2011 to 31 May 2016 in a university-affiliated hospital in Taiwan. A total of 1358 patients were enrolled, of whom 36 (2.65%) had skin eruptions. The female patients had a significantly higher odds ratio (OR) 2.24 (95% confidence interval (CI) 1.11–4.53, p = 0.021) of having skin eruptions. A history of asthma was also a significant risk factor (OR 2.04, 95% CI = 1.01–4.14, p = 0.043). Female asthmatic patients had the highest risk of skin eruptions (10/129, 7.2%) with an adjusted OR up to 4.45 (95% CI = 1.81–10.93, p < 0.001) compared to male and non-asthmatic patients. Of note, up to 58.3% (21/36) of the patients experienced a skin rash after they had completed and stopped Gemifloxacin. The median onset time was on the second day (ranging one to five days) after completing treatment. We reported that female asthmatic patients have the highest risk of Gemifloxacin-associated skin eruptions in Asia and that they highlighted a unique delayed onset skin rash.
SIRT1-Dependent Upregulation of Antiglycative Defense in HUVECs Is Essential for Resveratrol Protection against High Glucose Stress
Authors: Santini Silvano Junior , Cordone Valeria , Mijit Mahmut , Bignotti Virginio , Aimola Pierpaolo , Dolo Vincenza , Falone Stefano , Amicarelli Fernanda
Published: September 2019

Uncontrolled accumulation of methylglyoxal (MG) and reactive oxygen species (ROS) occurs in hyperglycemia-induced endothelial dysfunction associated with diabetes. Resveratrol (RSV) protects the endothelium upon high glucose (HG); however, the mechanisms underlying such protective effects are still debated. Here we identified key molecular players involved in the glycative/oxidative perturbations occurring in endothelial cells exposed to HG. In addition, we determined whether RSV essentially required SIRT1 to trigger adaptive responses in HG-challenged endothelial cells. We used primary human umbilical vein endothelial cells (HUVECs) undergoing a 24-h treatment with HG, with or without RSV and EX527 (i.e., SIRT1 inhibitor). We found that HG-induced glycative stress (GS) and oxidative stress (OS), by reducing SIRT1 activity, as well as by diminishing the efficiency of MG- and ROS-targeting protection. RSV totally abolished the HG-dependent cytotoxicity, and this was associated with SIRT1 upregulation, together with increased expression of GLO1, improved ROS-scavenging efficiency, and total suppression of HG-related GS and OS. Interestingly, RSV failed to induce effective response to HG cytotoxicity when EX527 was present, thus suggesting that the upregulation of SIRT1 is essential for RSV to activate the major antiglycative and antioxidative defense and avoid MG- and ROS-dependent molecular damages in HG environment.
A Bibliometric Review of the Keap1/Nrf2 Pathway and its Related Antioxidant Compounds
Authors: Paunkov Ana , Chartoumpekis Dionysios V. , Ziros Panos G. , Sykiotis Gerasimos P.
Published: September 2019

Nrf2 is a master transcriptional regulator of antioxidant and cytoprotective pathways. Currently in its third decade, research on Nrf2 has expanded to encompass not only basic but also clinical studies. In the present bibliometric review, we employed the VOSviewer tool to describe the existing Nrf2 literature landscape. As of July 2019, 11,931 papers on Nrf2 were listed in the “Web of Science” database, with more than 1000 new papers published each year. As expected, terms related to oxidative stress and antioxidant molecules occur very often in the Nrf2 literature throughout the years. Interestingly, there is also a gradual increase in the occurrence of terms related to diseases or to natural compounds, the most prominent being sulforaphane, curcumin, and resveratrol that modulate the Nrf2 pathway. Going beyond molecular biology/biochemistry and related fields, Nrf2 research has begun to spread into more clinical areas like endocrinology/metabolism, cardiology, and nephrology, likely reflecting an increased interest in clinical applications of Nrf2 pathway activators. China has become the most prolific producer of Nrf2 papers the last five years followed by the USA and Japan, a reverse pattern compared to the past. In conclusion, Nrf2 is the subject of a globally active research field that keeps growing and extends from bench to bedside.
The Non-Covalent Interactions and In Vitro Radical Scavenging Activities of the Caseinate-Galangin and Caseinate-Genistein Complexes
Authors: Ma Chun-Min , Zhao Xin-Huai
Published: September 2019

Non-covalent interactions and in vitro radical scavenging activities of the complexes formed by the commercial milk protein product caseinate and one of the two polyphenols (galangin and genistein) were assessed by the multi-spectroscopic techniques, molecular docking, and detection of scavenging activities against the 1,1–diphenyl-2-picryl-hydrazyl (DPPH), 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and hydroxyl radicals. The caseinate bound with the two polyphenols showed conformational changes and increased scavenging activities, compared with original caseinate. The caseinate-polyphenol binding was driven by the hydrophobic interaction and hydrogen-bonds, while hydrophobic interaction was the main binding force. Meanwhile, sodium dodecyl sulfate and urea could damage the essential hydrophobic interaction and hydrogen-bonds, respectively, and thus led to decreased apparent binding constants for the caseinate-polyphenol binding. Based on the measured values of several apparent thermodynamic parameters like ΔH, ΔS, ΔG, and donor–acceptor distance as well as the detected radical scavenging activity, galangin having more planar stereochemical structure and random B-ring rotation always had higher affinity for caseinate than genistein having location isomerism and twisted stereochemical structure, while the caseinate-galangin complex showed higher radical scavenging activity than the caseinate-genistein complex. It is thus concluded that both chemical and stereochemical structures of polyphenols are crucial to the affinity of polyphenols for protein and antioxidant activities of the protein-polyphenol complexes.
Polyphenol-Rich Extracts Obtained from Winemaking Waste Streams as Natural Ingredients with Cosmeceutical Potential
Authors: Matos Melanie S. , Romero-Díez Rut , Álvarez Ana , Bronze M. R. , Rodríguez-Rojo Soraya , Mato Rafael B. , Cocero M. J. , Matias Ana A.
Published: September 2019

Phenolics present in grapes have been explored as cosmeceutical principles, due to their antioxidant activity and ability to inhibit enzymes relevant for skin ageing. The winemaking process generates large amounts of waste, and the recovery of bioactive compounds from residues and their further incorporation in cosmetics represents a promising market opportunity for wine producers and may contribute to a sustainable development of the sector. The extracts obtained from grape marc and wine lees, using solid–liquid (SL) extraction with and without microwave (MW) pretreatment of the raw material, were characterized in terms of antioxidant activity through chemical (ORAC/HOSC/HORAC) and cell-based (keratinocytes—HaCaT; fibroblasts—HFF) assays. Furthermore, their inhibitory capacity towards specific enzymes involved in skin ageing (elastase; MMP-1; tyrosinase) was evaluated. The total phenolic and anthocyanin contents were determined by colorimetric assays, and HPLC–DAD–MS/MS was performed to identify the main compounds. The MW pretreatment prior to conventional SL extraction led to overall better outcomes. The red wine lees extracts presented the highest phenolic content (3 to 6-fold higher than grape marc extracts) and exhibited the highest antioxidant capacity, being also the most effective inhibitors of elastase, MMP-1 and tyrosinase. The results support that winemaking waste streams are valuable sources of natural ingredients with the potential for cosmeceutical applications.
Ozonation of Hot Red Pepper Fruits Increases Their Antioxidant Activity and Changes Some Antioxidant Contents
Authors: Sachadyn-Król Monika , Materska Małgorzata , Chilczuk Barbara
Published: September 2019

The effect of treatment of pepper fruits with gaseous ozone and storage time following the ozonation process on changes in the content of lipophilic fraction is analyzed for the first time in this paper. The aim of the present study was to assess the impact of ozone treatment on the composition of lipophilic compound fraction and its antioxidant activity (AA). Pepper fruits of cv. Cyklon were ozonated for 1 and 3 h immediately after harvesting. Then, the fruits were stored for 30 days under refrigeration conditions. The total content of phenolic compounds and the AA of the lipophilic fraction isolated from the pericarp and placenta of the fruits were investigated after 10, 20, and 30 days of storage. Additionally, quantitative high-performance liquid chromatography diode array detection analysis of individual phenolic compounds was performed. The results revealed that the content and activity of secondary metabolites varied during storage, with the highest values recorded on the 20th day after harvest, both in control and ozonated fruits, regardless of the ozone dosage used. Treatment of the fruits with ozone for 3 h, but not for 1 h, exhibited a positive effect on the phenolic composition and AA during the prolonged storage of pepper fruits. Three hours of ozonation seems to be the appropriate time to increase the persistence of pepper fruits during storage.
Polyamine Induction in Postharvest Banana Fruits in Response to NO Donor SNP Occurs via l-Arginine Mediated Pathway and Not via Competitive Diversion of S-Adenosyl-l-Methionine
Authors: Lokesh Veeresh , Manjunatha Girigowda , Hegde Namratha S. , Bulle Mallesham , Puthusseri Bijesh , Gupta Kapuganti Jagadis , Neelwarne Bhagyalakshmi
Published: September 2019

Nitric oxide (NO) is known to antagonize ethylene by various mechanisms; one of such mechanisms is reducing ethylene levels by competitive action on S-adenosyl-L-methionine (SAM)—a common precursor for both ethylene and polyamines (PAs) biosynthesis. In order to investigate whether this mechanism of SAM pool diversion by NO occur towards PAs biosynthesis in banana, we studied the effect of NO on alterations in the levels of PAs, which in turn modulate ethylene levels during ripening. In response to NO donor sodium nitroprusside (SNP) treatment, all three major PAs viz. putrescine, spermidine and spermine were induced in control as well as ethylene pre-treated banana fruits. However, the gene expression studies in two popular banana varieties of diverse genomes, Nanjanagudu rasabale (NR; AAB genome) and Cavendish (CAV; AAA genome) revealed the downregulation of SAM decarboxylase, an intermediate gene involved in ethylene and PA pathway after the fifth day of NO donor SNP treatment, suggesting that ethylene and PA pathways do not compete for SAM. Interestingly, arginine decarboxylase belonging to arginine-mediated route of PA biosynthesis was upregulated several folds in response to the SNP treatment. These observations revealed that NO induces PAs via l-arginine-mediated route and not via diversion of SAM pool.
Formulation of Broccoli Sprout Powder in Gastro-Resistant Capsules Protects against the Acidic pH of the Stomach In Vitro but Does Not Increase Isothiocyanate Bioavailability In Vivo
Authors: Zawari Masuma , Poller Bettina , Walker Greg , Pearson Andree , Hampton Mark , Carr Anitra C.
Published: September 2019

Broccoli sprout powder is a rich source of glucosinolates, which are hydrolysed to isothiocyanates in the presence of the enzyme myrosinase. We showed that in vitro incubation of broccoli sprout powder extract with isolated lymphocytes resulted in the upregulation of transcription factor Nrf2, however, there was no increase in Nrf2 protein levels in lymphocytes isolated 3 h following the ingestion of broccoli sprout powder by healthy volunteers. This highlights the general issue that potential health benefits of food-derived compounds can be compromised by limitations in bioavailability. In vitro experiments showed that the generation of isothiocyanates was reduced when the powder was first exposed to the low pH (1.2) of the stomach and then transferred to the higher pH (6.8) of the intestine. The loss of activity due to pre-exposure to the low stomach pH indicates that formulating the broccoli sprout powder in gastro-resistant formulations should increase that amount of isothiocyanate generated in the intestine for absorption. Gelatin capsules were hand-coated with either Eudragit® L100 or Eudragit® L100-55 and were assessed for their gastro-resistant properties using paracetamol as a model active for dissolution studies. Disintegration and dissolution studies showed that Eudragit® L100-55 coated capsules and DRcapsTM (Capsugel®) failed the United States Pharmacopeia (USP) requirements for gastro-resistant capsules, whereas the Eudragit® L100 coated capsules passed. Five healthy participants were administered 1 g of broccoli sprout powder, ingested either with water or encapsulated in uncoated or gastro-resistant capsules. Urinary excretion of isothiocyanate metabolites over the 24 h period post ingestion was assessed by HPLC. Broccoli sprout powder and uncoated gelatin-encapsulated powder showed comparable excretion of isothiocyanate metabolites (18.4 ± 2.3 and 23.9 ± 2.7 µmol, respectively). The enteric coated capsules provided a significantly longer Tmax than the uncoated gelatin capsules (15.4 ± 2.3 versus 3.7 ± 0.7 h, respectively), indicating protection from disintegration in the stomach, however, the excretion of isothiocyanate metabolites was significantly decreased compared with uncoated capsules (i.e., 8.5 ± 1.1 µmol). The lower in vivo formation or absorption of isothiocyanates observed for the gastro-resistant capsules may be due to participant variation in intestinal pH or transit times, resulting in inappropriate pH conditions or insufficient time for the complete disintegration and dissolution of the capsules.