bluuebunny/crossref_metadata_2025 huggingface dataset:
Di-(2-ethylhexyl) phthalate and its Metabolites Research Trend: A Bibliometric Analysis
Authors: Ri Hyonju , Zhu Ying , Jo Hyonsu , Miao Xiaohan , Ri Unsim , Yin Jianli , Zhou Liting , Ye Lin
Published: May 2023

Background:Di-(2-ethylhexyl) phthalate (DEHP) is one of the most widely used plasticizers.Many studies focus on the impact of continuous exposure to DEHP on humans and ecosystems.In this study, the bibliometric analysis of DEHP and its metabolites research was conducted to assess the research performances, hotspot issues, and trends in this field.
Method:The data was retrieved from a web of science core collection online database.VOSviewer 1.6.18 was used to analyze.
Result:A total of 4672 publications were retrieved from 1975 to 2022 October 21.The number of publications and citations increased annually in the last decades.China had the largest number of publications and the USA had the highest co-authorship score.The most productive and most frequently cited institutions were the Chinese Academy of Sciences and the Centers for Disease Control & Prevention(USA) , respectively.The journal with the most publications was Science of Total Environment and the most cited one was Environmental Health Perspectives.The most productive and cited author was Calafat AM(USA).The most cited reference was “Phthalates: Toxicology and exposure”.Four hotspot issues were as follows: influences of DEHP on the organisms and its possible mechanisms; assessment of DEHP exposure to the human and its metabolism; dynamics of DEHP in external environments; indoor exposure of DEHP and health outcomes.The research trends were DNOP, preterm birth, gut microbiota, microplastics, lycopene, hypertension, and thyroid hormones.
Conclusion:This paper will be a useful resource for researchers to rapidly take the valuable information related to the authoritative scholars, publications, journals and institutions, hotspot issues, and trends in this research field.
Effects of salinity on methane emissions and methanogenic archaeal communities in different habitat of saline-alkali wetlands
Authors: Li Feng , Li Huiju , Su Huihui , Du Wei , Gao Zhongyan , Liu Huajun , Liang Hong , Gao Dawen
Published: May 2023

The increase in temperature caused by global climate change has promoted the salinization of wetlands. Inland saline-alkaline wetlands have an environment of over-humidity and shallow water and are hot spots for CH4 emissions. However, there are few reports on the effect of salinity on CH4 emissions in inland saline-alkaline wetlands. This study revealed the effects of salinity, habitat, and their interactions on CH4 emissions, and explored the response of methanogenic archaea to salinity. Overall, salinity inhibited CH4 emissions. But there were different responses in the three habitat soils. Salinity decreased the relative abundance of methanogenic archaea and changed the community structure. In addition, salinity changed soil pH and dissolved organic carbon (DOC) and ammonium (NH4+) concentrations, which were significantly correlated with methanogenic archaea. Our study showed that salinity changed the soil physicochemical properties and characteristics of the methanogenic archaeal community, affecting CH4 emissions.
Multi-ancestry GWAS of Fuchs corneal dystrophy highlights roles of laminins, collagen, and endothelial cell regulation
Authors: Peachey Neal , Gorman Bryan , Francis Michael , Nealon Cari , Halladay Christopher , Duro Nalvi , Markianos Kyriacos , Genovese Giulio , Hysi Pirro , Choquet Hélène , Afshari Natalie , Li Yi-Ju , Gaziano J. Michael , Hung Adriana , Wu Wen-Chih , Greenberg Paul , Pyarajan Saiju , Lass Jonathan , Iyengar Sudha
Published: May 2023

Fuchs endothelial corneal dystrophy (FECD) is a leading indication for corneal transplantation, but its molecular pathophysiology remains poorly understood. We performed genome-wide association studies (GWAS) of FECD in the Million Veteran Program (MVP) and meta-analyzed with the previous largest FECD GWAS, finding twelve significant loci (eight novel). We further confirmed the TCF4 locus in admixed African and Hispanic/Latino ancestries, and found an enrichment of European-ancestry haplotypes at TCF4 in FECD cases. Among the novel associations are low frequency missense variants in laminin genes LAMA5 and LAMB1 which, together with previously reported LAMC1, form laminin-511 (LM511). AlphaFold 2 protein modeling suggests that mutations at LAMA5 and LAMB1 may destabilize LM511 by altering inter-domain interactions or extracellular matrix binding. Finally, phenome-wide association scans and co-localization analyses suggest that the TCF4 CTG18.1 trinucleotide repeat expansion leads to dysregulation of ion transport in the corneal endothelium and has pleiotropic effects on renal function.
A Round-shaped, Radio-opaque Foreign Body on Chest Radiograph of an Elderly Woman, Identified as An Intact Lanthanum Carbonate Tablet
Authors: Tungtrongchitr Nuttapat , Krisem Massupa , Taesilapasathit Chalothorn , Suppadungsuk Supawadee , Thammavaranucupt Kanin
Published: May 2023

Background:Lanthanum carbonate is a phosphate binder in the form of a chewable tablet, which is commonly prescribed in chronic kidney disease patients. We reported an unusual radio-opaque foreign body which was accidentally found in a chest X-ray of an elderly female patient and later identified as an intact lanthanum carbonate tablet.Case Presentation:A 60-year-old woman with end stage renal disease, receiving lanthanum carbonate was found having a coin-shaped, homogeneous radiopaque foreign body in the position of esophagus of her chest X-ray. Due to awareness of mimicking other conditions (e.g. button battery or coin ingestion), urgent endoscopy was performed. An intact lanthanum carbonate tablet was found in the upper stomach and was removed successfully.Conclusion:Physicians should be aware of unchewed lanthanum carbonate tablets when a metallic-like object is detected on chest radiograph of a lanthanum carbonate user. Also, prescription of chewing medication should be cautioned particularly in an elderly female patient.
Characterization of autoimmune eye disease in association with Down's Syndrome
Authors: Rosenbaum James , Zaki Amr , Pasadhika Sirichai , Huang Jerry , Thomas Akshay , Burkholder Bryn , Lim Lyndell , Llop Stephanie , Suhler Eric , Adamus Grazyna
Published: May 2023

Background
Autoimmunity and deficiency of the transcription factor autoimmune regulator protein (AIRE) are known associations with Down Syndrome (DS). Lack of AIRE abrogates thymic tolerance. The autoimmune eye disease associated with DS has not been characterized. We identified a series of subjects with DS (n = 8) and uveitis. In 3 consecutive subjects, we tested the hypothesis that autoimmunity to retinal antigens might be a contributing factor.
Subjects/Methods:
This was a multicentered, retrospective case series. De-identified clinical data of subjects with both DS and uveitis were collected via questionnaire by uveitis-trained ophthalmologists. Anti-retinal autoantibodies (AAbs) were detected using an Autoimmune Retinopathy Panel tested in the OHSU Ocular Immunology Laboratory.
Results
We characterized 8 subjects (mean age 29 [range, 19–37] years). The mean age of uveitis onset was 23.5 [range, 11–33] years. All 8 subjects had bilateral uveitis (p < 0.001 based on comparison to published university referral patterns), with anterior and intermediate uveitis found in 6 and 5 subjects respectively. Each of three subjects tested for anti-retinal AAbs was positive. Detected AAbs included anti-carbonic anhydrase II, anti-enolase, anti-arrestin, and anti-aldolase.
Discussion
A partial deficiency in the AIRE on chromosome 21 has been described in DS. The similarities in the uveitis presentations within this patient group, the known autoimmune disease predisposition in DS, the recognized association of DS and AIRE deficiency, the reported detection of anti-retinal antibodies in patients with DS in general, and the presence of anti-retinal AAbs in 3 subjects in our series supports a causal association between DS and autoimmune eye disease.
Application of adaptive genetic algorithm and machine learning in English text analysis teaching system
Authors: Wang Xuan , Chen Yuanyuan
Published: May 2023

Fuzzy English text recognition will be affected by the complex background, resulting in low recognition accuracy. In order to improve the effect of English text recognition, it is necessary to remove the background. Based on the machine vision algorithm, this paper improves the traditional genetic algorithm to obtain an adaptive genetic algorithm, and builds an English text background elimination model based on the adaptive genetic algorithm. Moreover, this paper introduces the hill-climbing method with better local optimization effect to perform local optimization in the iterative process of genetic algorithm, and constructs an adaptive genetic algorithm based on the hill-climbing method to make up for the defects of local optimization in the evolution process of genetic algorithm. In addition, this paper constructs a projection pursuit clustering model based on hill-climbing adaptive genetic algorithm, and constructs the functional module of the English text background elimination model based on actual needs. Finally, this paper designs a control experiment to verify the performance of the model. The research results show that the effect of the model constructed in this paper is good.
125I seeds implantation for lymph nodes metastasisfrom radioactive iodine-refractory differentiated thyroid carcinoma: A short-term efficacy and dosimetry study
Authors: Lu Guoxiu , Zhang Wenwen , Hao Shanhu , Wang Zhiguo , Ji Liqiu , Ge Xiangyan , Li Gen , Wang Youchao , Zhang Guoxu
Published: May 2023

Objective: To investigate the feasibility and evaluate the safety and efficacy of CT-guided 125I radioactive particle implantation for the treatment of radioiodine-refractory differentiated thyroid cancer (RAIR-DTC) lymph node metastases. To verify the accuracy of the computerized three-dimensional treatment planning system (TPS) in the treatment of lymph node metastasis with the aid of 125I particle implantation from the dosimetric level.
Methods: A retrospective analysis of 42 patients with RAIR-DTC with lymph node metastases admitted to the Northern War Zone General Hospital between December 2016 and January 2019 was performed, in which physicians designed an intraoperative plan using TPS based on the patients' preoperative CT images and compared the dosimetric parameters validated postoperatively with the preoperative plan. This study further analyzed the changes in tumor size and tumor-related marker Tg values of patients at 2, 6, and 12 months postoperatively.
Results: The number of 125I radioactive particles implanted in 42 patients was 226. The local remission rates were 97.62% ( 41 /42), 88.10% ( 37 /42), and 85.71% ( 36 /42) at 2, 6, and 12 months postoperatively, respectively. The volume of the lesions was (4.44±1.57) cm3, (4.20±1.70) cm3, and (4.23±1.77) cm3 at 2, 6, and 12 months after treatment, respectively, which were significantly reduced from the preoperative baseline level (6.87±1.67) cm3 (t-values: 9.466, 9.923, 7.566, all p<0.05). The Tg levels were 15.95 (5.45, 73.93) μg/L, 8.90 (2.20, 39.21) μg/L, and 6.00 (1.93, 14.18) μg/L at 2, 6, and 12 months after treatment, respectively, which were significantly lower than the preoperative baseline levels of 53.50 (20.94, 222.92) μg/L (Z values: -5.258, -5.009, -4.987, all P < 0.001). Postoperatively, D90 was slightly lower than the prescribed dose in 95.23% (40/42) of patients, but the difference was not statistically significant [(12 378.8 ± 3 182.0) 、 (12 497.8 ± 1 686.4) cGy; t=0.251, P>0.05], and postoperative dose parameters D100 (6 881.5 ± 1 381.8) cGy, V150 (58.5 ±18.40)%) were lower than the preoperative plan D100 (8085.8±2330.0) cGy, V150 (66.5±17.70)%; t-value=8.913 and 3.032, both P<0.05; the remaining indicators were not significantly different from the preoperative plan (the differences in the number of implanted particles, PTV, V100, HI were not statistically significant (t/Z = - 0.593, -1.604, 1.493, -0.663, all P>0.05).
Conclusion: Referring to the preoperative plan of TPS, 125I particle implantation for RAIR-DTC lymph node metastasis can achieve the expected dose distribution, and the short-term tumor local control efficacy is definite, which is a safe and effective treatment method.
The impact of an oral nutritional supplement on body weight gain in older adults with malnutrition: an open-label randomized controlled trial
Authors: Jayawardena Ranil , Wickramawardhane Prasani , Dalpadadu Chamila , Hills Andrew P , Ranasignhe Priyanga
Published: May 2023

Background: The global aging population is expanding rapidly. This older population is particularly at higher risk of malnutrition. Malnutrition can lead to impaired body function, morbidity, and mortality. Meeting nutritional requirements is a key strategy to minimize multiple debilitating adverse outcomes associated with malnutrition in the elderly.
Oral nutritional supplements (ONS) have been widely used as a dietary intervention for malnutrition in older adults. These supplements provide additional nutrients and calories to support nutritional requirements and have been shown to improve nutritional status, physical function, and quality of life in malnourished older adults.
Methods: This is an open-label, randomized controlled, parallel-group study including 50 institutionalized older adults (aged > 60 years) with malnutrition or at risk of malnutrition, living in a selected elderly care institution in Colombo, Sri Lanka. The aim is to assess the healthy body weight gain in terms of an increase in muscle mass and fat mass in older adults with malnutrition at risk of malnutrition by using an oral nutritional supplement. The older adults will be screened for malnutrition using mini nutrition assessment (MNA) tool. Eligible participants will be randomized using simple random sampling technique to intervention and control groups (1:1 allocation ratio). The intervention group will consume 200 mL of ONS before bed continuously for 12 weeks. The primary outcome is the percentage who achieved at least 5% weight gain in the intervention group compared to the control group. Nutritional (anthropometric, biochemical, clinical, and dietary), body composition (Dual Energy X-ray Absorptiometry), frailty, functional (hand grip strength, knee extension, and Barthel index) cognitive (Montreal Cognitive Assessment), and physical activity will be measured as secondary outcomes prior at baseline and at the end of the 12 weeks. Some measurements will also be performed at end of the 4th week for anthropometry, dietary, and functional assessment. Data will be analyzed using SPSS V-23.
Discussion: This study will reveal whether the use of an ONS is effective in promoting healthy weight gain in older adults with malnutrition or at risk of malnutrition. In addition, investigating the impact of an ONS on multiple outcomes such as clinical, nutritional, functional, and cognitive function will provide a more comprehensive understanding of the potential benefits of these supplements.
Trial registration: Registered under Sri Lanka Clinical Trail Registry: SLCTR/2022/021
Clinical Outcomes and Spinal Growth After Posterior Hemivertebra Resection and Short Segment Fusion in Children
Authors: Du Yuxuan , Zhang Hongqi , Wang Yu-Xiang
Published: May 2023

In order to evaluate the corrective effect of posterior hemivertebra resection and short-segment fusion surgery on pediatric patients and to assess the impact of short-segment fixation surgery on vertebral development during follow-up, a retrospective analysis was performed on 28 pediatric patients who underwent posterior hemivertebra resection surgery. The corrective effect was evaluated by comparing the preoperative, postoperative, and final follow-up Cobb angle, upper and lower compensatory curves and trunk balance. Meanwhile, the vertebral and spinal canal diameters of instrumented vertebrae and adjacent noninstrumented vertebrae were measured and compared between preoperative and final follow-up to assess the vertebral and spinal canal development. The correction rate of main curve Cobb angle was 72.2%. The estimated mean vertebral volume of the instrumented vertebra was slightly lower than that of the unfused segment at the final follow-up, but the difference was not statistically significant. The growth rate of the spinal canal during follow-up was much smaller than that of the vertebral body. Although internal fixation surgery might have a slight inhibitory effect on vertebral development within the fused segment in younger patients, it does not cause iatrogenic spinal canal stenosis or neurological dysfunction. Posterior hemivertebra resection and short-segment fusion surgery are safe and effective.
Stability and Bautin bifurcation of four-wheel-steering vehicle system with driver steering control
Authors: Miao Pengcheng , Li Denghui , Grebogi Celso , Yue Yuan
Published: May 2023

In this paper, the lateral stability and Bautin bifurcation of a four-wheel-steering(4WS) vehicle system, by considering driver steering control, are investigated. By using the central manifold theory and projection method, the first and second Lyapunov coefficients are calculated to predict the type of Hopf bifurcation of the vehicle system. The topological structure of the Bautin bifurcation, a degenerate Hopf bifurcations of the 4WS vehicle system is presented in the parameter space and it reveals the dynamics of the vehicle system of different choices of the control parameters. The influences of system parameters on critical values of the bifurcation parameter are also analyzed. It is shown that with the increase of the frontal visibility distance of the driver control strategy coefficient and the cornering stiffness coefficients of the rear wheels, the critical speed increases. Nevertheless, the critical speed decreases with the increase of the distance from the center of gravity of the vehicle to the front axles, Driver’s perceptual time delay, and cornering stiffness coefficients of the front wheels.
Comparison of the properties of bioderived polycarbonate and traditional bisphenol-A polycarbonate
Authors: Wu Fang , Pu Zejun , Hou Hongbo , Li Xianyong , Zhu Rongli , Wang Xu , Yu DaYang , Zhong Jiachun
Published: May 2023

The bioderived polycarbonate (ISB-PC) was synthesized via transesterification and polycondensation of isosorbide (ISB) and diphenyl carbonate (DPC), using lithium acetoacetone as catalyst. The resulting ISB-PC exhibited high glass transition temperatures similaring to bisphenol A polycarbonate (BPA-PC), and were thermally stable up to 350 ℃. The incorporation of isosorbitol into the polymer chain imparted an improved mechanical property of ISB-PC, such as a higher bending and tensile modulus and higher elongation at break. The ISB-PC can be readily cast into transparent films with a tensile strength of 73.3 MPa and a tensile modulu of 534 MPa. The ISB-PC displayed a highly UV transmittance and possessed a blue uorescence under the UV irradiation. At the same time, ISB-PC also has strong anti-yellowing ability.
Effects of probiotic supplementation (Saccharomyces cerevisiae) on pancreatic alpha and beta cells and energy metabolic profile in broilers
Authors: Peña Silvana J. , Salazar Johan S. , Pardo Jhon F. , Roa Maria L. , Corredor-Matus José R. , Ochoa-Amaya Julieta E
Published: May 2023

The use of growth-promoting antibiotics has increased bacterial resistance, making made it urgent to look for options in nutritional supplementation with probiotics. This, in turn, can contribute to improving nutrition as well as welfare of broilers.
Objective: To assess the effect of supplementation with Saccharomyces cerevisiae (SC) on areas of islets of Langerhans and alpha and beta cells (α- and β-cells) in broilers by immunohistochemistry (IHC). To correlate areas of α- and β-cells in relation to pancreatic islet area, glucose, and insulin in both SC-supplemented and control groups. To correlate data obtained for triglycerides, total, HDL, and LDL cholesterol, and histological parameters of vacuolar assessment in central splenic arteriole and coronary arteries in both treatments.
Materials and Methods: Two treatments were assessed: T1 (control group without probiotics; n = 10) and T2 (group treated with Saccharomyces cerevisiae; n = 14). Islet areas were measured according to the number of islets established per animal, with number of islets per individual equal to five for groups T1 (n = 10) and T2 (n = 14). Alpha and beta cells were measured by IHC (40x) with primary anti-glucagon (clone EP74) and anti-insulin (clone EP125) antibodies. Serum glucose and insulin were determined by spectrophotometry. Statistical analysis employed "t" tests for unpaired samples and Pearson’s correlation.
Results: HDL cholesterol increased in T2 (14.54 ± 0.979) (p = 0.0365) as compared to T1 (12.20 ± 0.8424) mg/dL. Glycemia decreased in T2 (p = 0.01) (244.7 ± 7.5) vs. T1 (297.9 ± 21.18).
Conclusion: Dietary supplementation with Saccharomyces cerevisiae (CS) decreased serum glycemia without affecting insulin. It modified the correlation of areas of pancreatic cell population in islets of Langerhans and enlarged areas of α-cells vs. β-cells, thereby maintaining blood glucose homeostasis. In addition, SC increased levels of high-density cholesterol (HDL) in the blood.
Financial support: General Directorate of Research at Universidad de los Llanos.
Chili pepper extracts as potential anticancer agents targeting topoisomerases
Authors: HUDÁKOVÁ Terézia , ŠEMELÁKOVÁ Martina , OČENÁŠ Peter , KOŽURKOVÁ Mária , KROCHTOVÁ Kristína , SOVOVÁ Simona , TÓTHOVÁ Zuzana , GUĽÁŠOVÁ Zuzana , POPELKA Peter , SOLÁR Peter
Published: May 2023

This study aimed to explain the effect of extracts from chili pepper varieties containing capsaicin and dihydrocapsaicin, among other substances, on the growth of colon cancer in humans through therapeutic research and drug screening. DNA topoisomerases regulate conformational changes in DNA topology during normal cell growth, such as replication, transcription, recombination, and repair, and may be targeted for anticancer drugs. A DNA topology assay was used to investigate DNA-damaging/protective activities of extracts from Habanero Red (HR), Habanero Maya Red (HMR), Trinidad Moruga Scorpion (TMS), Jalapeno (J), Serrano (SP), Habanero Red Savina (HRS), Bhut Jolokia (BJ), and Jamaica Rosso (JR) peppers, demonstrating their inhibitory effect on the relaxation of pBR by Topo I. DNA topoisomerase II (Topo II) is proven therapeutic target of anticancer drugs. Complete inhibition of Topo II was observed for samples TMS, HR, and HMR. Extracts J and SP had the lowest capsaicin and dihydrocapsaicin content compared to other peppers. HR, HMR, TMS, J, S, HRS, BJ, JR extracts showed the antiproliferative effect, examined by MTS and xCell assay on the in vitro culture of the cancer cell line HCT116.
Comparison of Bb With Meta-heuristic Approach in Optimization of Three Stage Fss With Multiple Processors
Authors: Malhotra Khushboo , Gupta Deepak , Goel Sonia , Tripathi A. K.
Published: May 2023

Flow shop scheduling model (FSSM) is an important area of research in the field of Scheduling theory and it has many real applications in the industrial field. This study involves flow shop scheduling problem having machines on three levels in which utilization time of each task is considered as fuzzy triangular number. The concept of like parallel machines at each stage is also considered. Unit operational costs of jobs are also involved. The goal of this research is to recommend a heuristic approach inspired by Genetic algorithm (GA) which on implementation, provides an optimal or near-optimal schedule to reduce the make-span. Numerical example is also given to establish the usefulness of the proposed approach, and to approve the presentation, the results are compared with the existing methods like Branch and Bound (B & B).
Immune humanized mice reconstituted with peripheral blood mononuclear cells or hematopoietic stem cells develop distinct MDA-MB-231 tumor immune microenvironments
Authors: Wang Angela Jui-Ling , Chen Yi-Ting , Ma Wen-Hui , Liao Chia-Chi , Chiang Tien-Huang , Yu Chun-Keung , Su Yu-Chia
Published: May 2023

Triple-negative breast cancer (TNBC) is one of the most fatal subtype of breast cancer. Tumor immune microenvironments (TIMEs) have critical influences on TNBC therapies. However, syngeneic mouse tumor models are insufficient to evaluate immunotherapeutic efficacy, because the different immune responses between mice and human. Therefore, human xenograft tumor mouse models with humanized immune systems (HIS) are more suitable for evaluation of immunotherapeutic efficacy. In these study, two immune humanized mouse models transferred with human hematopoietic stem cells (hHSC-HIS) or human peripheral mononuclear cells (hPBMC-HIS) in our advanced severe immune deficiency (ASID) mice were generated. Both systemic immune profiling and TIMEs of TNBC MDA-MB-231 tumors from hHSC- and hPBMC-HIS ASID models were compared. Generation of the comprehensive human immune system and large amounts of human macrophages/bone marrow-derived stromal cells around the TIMEs were noted in hHSC-HIS ASID mice, but the growth of TNBC was not affected. In contrast, T cells dominated the systemic immune system and TIMEs in hPBMC-HIS ASID mice, and inhibited the tumor growth. In summary, the TIMEs of hHSC-HIS ASID model is suitable for validations of immunotherapies reversing immune suppression. The TIMEs of hPBMC-HIS ASID can be applied for cytotoxicity test of tumor specific T cells.
Distributed Adaptive Global Stabilization of a Class of Rigid Formation Systems
Authors: Wang Qin , Chen Zitao , Yi Yang , Shen Mouquan , Yang Jun
Published: May 2023

This paper proposes a distributed globally stable control strategy for a class of rigid formation systems. Specifically, the multiple equilibrium problem of distance-based formation control is solved for a class of rigid formation systems. Firstly, a scalable algorithm is given to check if the proposed rigid graph satisfies the specific structure and determine that each follower has only two neighbors to form a cascade interconnection. Secondly, according to the cascade structure induced by the given algorithm, the distributed perturbed gradient control law and the adaptive law are presented for the rigid formation system. Finally, the global convergence and stability properties are obtained using the cascade system stability theory and adaptive control theory. Simulations are provided to demonstrate the effectiveness of the globally asymptotically stable formation control strategy.
The Transcriptome Induced by Bazhen Decoction and its Function in G-quadruplex Resolving and Telomere Maintenance in Progeroid Cells
Authors: Li Chuanbiao , Tian Jie , Yang Jun , Wang Qianqian , Guo Bing , Huang Liming , Hu Ying , Luo Ying
Published: May 2023

BackgroundThe Bazhen decoction is one of the most extensively used Traditional Chinese medicine (TCM) prescriptions for anti-aging. However, due to the complicity of the components, the pharmacological mechanism of Bazhen decoction is still limited.MethodsWe applied RNA sequencing and transcriptome analysis to get the full view of the signaling pathways regulated by Bazhen decoction in the wild type cell background. By using the progeroid cells derived from Werner syndrome mice, we applied Western blot, Immunofluorescence, flow cytometry and telomere FISH to verify the transcriptome data.ResultsThe transcriptome profile revealed that Bazhen decoction might systematically regulate multiple anti-aging pathways, including stem cell regulation, protein homeostasis, cardiovascular function, neuronal function, anti-inflammation, anti-DNA damage induced stress, DNA helicase activity and telomere lengthening. We found that multiple DNA helicases and telomere regulating proteins were up-regulated by Bazhen decoction, which promoted the resolving of G-quadruplex (G4) structure, and facilitated DNA replication and telomere elongation. These improvements also endowed the cellular resistance to DNA damages induced by replication stress. Together these data suggest that Bazhen decoction facilitate G4 resolving and telomere maintenance, which might contribute to the longevity sustaining properties revealed by transcriptome profile.ConclusionsOur data revealed a new strategy for recovering the pharmacological signature pathways for TCM, which could help the clinical precision medicine of TCM. By applying transcriptome in TCM-treated normal cell, we tried out a systematic analysis for dissecting the molecular mechanism of complicated TCM prescription in the normal genetic background.
High-throughput Design of a Lightweight and Ultra-strong Refractory Eutectic High-Entropy Alloy with Outstanding Irradiation Resistance
Authors: Liaw Peter , Yang Chao , Wang Beiyang , Shen Gaoyuan , Wei Tao , Wu Mingxu , Tao Qingzhou , Wang Shubin , Shu Da , Sun Baode
Published: May 2023

Lightweight, strong, and radiation-tolerant materials are essential for advanced nuclear systems and aerospace applications. However, the current research for these materials mainly focuses on a single design strategy to improve their irradiation resistance via empirical trial-and-error learning. In this study, a novel NbVTaSi refractory eutectic high-entropy alloy was target designed via high-throughput thermodynamic calculations. To exploit the unique eutectic structures of NbVTa and β-Nb5Si3 phases, a new synergistic mechanism for irradiation resistance via balancing inhibition effects on the generation of He-induced lattice defects and the formation and growth of He bubbles was proposed according to the experimental findings and density functional theory calculations. The alloy possesses lightweight (7.4 g/cm3), high yield strengths at room temperature (2.60 GPa) and 850 ℃ (1.84 GPa), and outstanding He-irradiation resistance, superior to other reported radiation-resistant alloys. This study sheds light on the development of future radiation-tolerant materials for advanced nuclear systems and aerospace applications.
Design of Sports Multimedia Teaching Platform Based on machine learning
Authors: Luo Changwei
Published: May 2023

Due to the rapid development of multimedia technology, communication technology and information technology in China, scholars in the field of education gradually focus their research on new educational models, which are represented by educational technology and can use multimedia to present internal forms, such as physical education. Therefore, under this background, this paper deeply develops a kind of PE teaching platform based on multimedia network system by combining modern communication technology, multimedia technology, computer technology, network technology and other mature college campus networks. Firstly, this paper investigates the design of machine learning decision tree algorithm and random forest algorithm, and discusses the application of machine learning in multimedia feature extraction and data processing; Then according to the actual needs, the structure of sports multimedia teaching platform is constructed, the relevant functions are analyzed, and the results of QoE multimedia experiment are integrated and tested. After the establishment of sports multimedia teaching platform, this paper uses this platform to practice, so as to analyze the teaching skills of physical education teachers in sports multimedia teaching platform, evaluate students' satisfaction, and discuss the application of multimedia teaching platform in sports teaching and the performance and influencing factors of the system with students. The experimental results show that the sports multimedia teaching platform proposed in this paper has a certain role in promoting the improvement of College Students' physical education curriculum performance, so it is worth popularizing.
Dietary Vitamins and DMFT index in Rafsanjan adults, a Cross- sectional Study on Rafsanjan Adults Cohort Data
Authors: Sardari Farimah , Khalili Parvin , jamali Zahra , Rezvaninejad Rayehehossadat , Rezvaninejad Raziyehsadat , Eslami Amirhosein
Published: May 2023

Introduction: Vitamins are generally known to be important in oral health. Some associations have been found between vitamins and dental caries, but these findings have been controversial so far. This study aimed to investigate the associations of dietary intakes of vitamins and DMFT index.
Methods and materials: In this cross-sectional study, the study population was 3028 subjects aged 35-70 years from Rafsanjan Cohort Study's Oral Health Branch (OHBRCS) which is a branch of Rafsanjan Cohort Study (RCS). RCS is a part of the prospective epidemiological research studies in IRAN (PERSIAN). Subjects’ demographic information, variables related to oral health, history of underlying diseases, history of smoking, alcohol, and opium use based on questionnaires and checklists produced by the Persian cohort team was obtained and also dietary intakes of vitamin A, vitamin E and vitamin B family were collected by a validated food frequency questionnaire. Linier regression analysis was used to investigate the association between intake of dietary vitamins and DMFT (Decayed, Missing, and filled Teeth) using crude and adjusted models.
Results: The findings showed low levels of education and socio-economic status, older age, smoking and opium consumption, and decreasing the frequency of brushing are significantly associated with an increase in the DMFT index. DMFT index were more unfavorable in people with dietary intake ≤ median of all measured vitamins. In fully adjusted model, DMFT index showed a significant negative relationship with dietary intakes of Vitamin A, β_carotene, lutein_zea xanthin, Vitamin E, Vitamin K, thiamin, Vitamin B6, and folate (Unstd.B =-0.54, 0.63,0.86,0.49,0.88,0.63,0.66,0.54,respectively).
Conclusion: Increasing the intake of Vitamin A, β_carotene, lutein_zea xanthin, Vitamin E, Vitamin K, thiamin, Vitamin B6, and folate may be associated with the low DMFT index, so it is recommended to use more this category of vitamins.
A Study on the Facade Decorative Pattern of Modern Buildings in Kulangsu Taking the Gate House Decoration as an Example
Authors: Qian Yi , Hu Shen
Published: May 2023

The architectural decoration of Kulangsu is complex and magnificent, including the characteristics and styles of classicism, eclecticism, traditional style of southern Fujian, and decorative style of Amoy. It is a treasure house of architectural decoration patterns. At the same time, the development of Kulangsu architecture is the same as the internationalization of modern architecture. Therefore, many modern style gatehouse decoration appeared in the buildings of Kulangsu. Based on the outline of the gate building, the way of arching and the significance of decorative patterns, this paper traces its origin and analyzes its geometry. The geometric relationship in the decoration of the gate house on Kulangsu Island is sorted out, and the gate house style and the gate house mountain flower style are specifically and systematically classified. It is hoped that the relationship between overseas Chinese, local residents and colonists in Southeast Asia can be explained by tracing the origin of architectural decoration.
The Long-term Impact of Post-Operative Oral Contraceptive Recommendations After Laparoscopic Cystectomy of Endometrioma on the Incidence of Endometrioma Recurrence and Ovarian Cancer Development
Authors: Maki Eiko , Takamura Masashi , Koga Kaori , Izumi Gentaro , Satake Erina , Takeuchi Arisa , Makabe Tomoko , Haraguchi Hirofumi , Harada Miyuki , Hirata Tetsuya , Hirota Yasushi , Wada-Hiraike Osamu , Osuga Yutaka
Published: May 2023

Background Previous studies have shown the ovarian carcinoma after laparscopic cystectomy of endometrioma arises through the recurrence of endometrioma. Then it can be assumed that reduction of ovarian endometrioma recurrence through postoperative medication can lead prevention of carcinogenesis. Therefore, this study aimed to evaluate the long-term impact of oral contraceptive (OC) recommendation after laparoscopic cystectomy of endometrioma on the incidence of endometrioma recurrence and ovarian cancer development.Methods This retrospective study included 546 patients who underwent laparoscopic cystectomy of ovarian endometrioma at a tertiary referral hospital to evaluate the OC recommendation following laparoscopic cystectomy of endometrioma introduced after the year 2005.Results This study included 218 patients in the pre-recommendation group and 328 patients in the post-recommendation group. Patient characteristics (age, gravida, parity at surgery, comorbidity of uterine fibroids and adenomyosis, revised American Society for Reproductive Medicine score, cyst size, and bilateral involvement) were comparable between the groups. Postoperative OC was recommended to be started and continued for at least 2 years in 3.2% of patients in the pre-recommendation group and 38.7% of patients in the post-recommendation group. The endometrioma recurrence rate was significantly lower in the post-recommendation group (3.8% per year) than in the pre-recommendation group (6.8% per year, p < .001). The incidence of ovarian cancer was lower in the post-recommendation group (0.063% per year) than in the pre-recommendation group (0.248% per year), although this difference was not significant. None of the patients who had used OC for > 2 years developed ovarian cancer.Conclusions Introduction of the postoperative OC recommendation after laparoscopy significantly reduced the recurrence rate of endometrioma, and tended to reduce the incidence of ovarian cancer.
In it Together: Sense of Community and Psychologic Distress During COVID-19
Authors: Wu Kimberly , Doe Erica , Roude Gabriela , Wallace Jasmine , Francois Samantha , Richardson Lisa , Theall Katherine
Published: May 2023

We assessed the relationship between differences in indicators of social capital before and during the COVID-19 pandemic, and their association with self-reported measures of psychological distress. The data was analyzed from an existing cluster randomized control trial (the Healthy Neighborhoods Project) with 244 participants from New Orleans, Louisiana. Differences in self-reported scores between baseline (January 2019-March 2020) and participant’s second survey (March 20, 2020, and onwards) were calculated. Logistic regression was employed to examine the association between social capital indicators and measures of psychological distress adjusting for key covariates and controlling for residential clustering effects. Participants who reported higher than average scores for social capital indicators were significantly less likely to report increases in psychosocial distress between pre and during the COVID-19 pandemic. Those who reported higher-than-average sense of community were approximately 1.2 times less likely than those who reported lower than average sense of community scores to experience increases in psychological distress before and during the global pandemic (OR = 0.79; 95% CI = 0.70,0.88, p ≤ 0.001), even after controlling for key covariates. Findings highlight the potentially important role that community social capital and related factors may play in the health of underrepresented populations during times of major stress. Specifically, the results suggest an important role of cognitive social capital and perceptions of community membership, belonging, and influence in buffering changes of mental health distress experienced during the initial period of the COVID-19 pandemic among a population that is majority Black and female.
Improving soil pH, nutrient concentrations, and enzyme activities by green manure returning in young and mature rubber plantation on Hainan Island, China
Authors: xu wenxian , Yang Qiu , Jiang Yamin , Yu Jianan , Li Jiale , Liu Wenjie , Wu Zhixiang
Published: May 2023

BackgroundStudying green manure decomposition in various returning methods can establish a scientific foundation for farmland nutrient management.MethodsIn a rubber plantation on Hainan Island, China, utilized the nylon mesh bag method to imitate the decomposition of kudzu (whole plant, stem, and leaf) under two returning methods (mulching and burying) in two different sites (young and mature rubber plantations). The decomposition rate and nutrient release dynamics of kudzu and investigated the impact of kudzu returning on various soil properties such as soil pH, soil organic carbon (SOC), total nitrogen (TN), total phosphorus (TP), nitrate nitrogen (NO3−-N), ammonium nitrogen (NH4+-N), available phosphorus (AP), and enzyme activities were analyzed.ResultsCompared with mulching, the burying returning method significantly increased the kudzu decomposition rate and nutrient release proportions. After 270 days, more than 80% of the C, N, and P in different components of kudzu were released. The decomposition rate was found to be more affected by the initial soil factors than by the endogenous nutrients of kudzu. Compared with CK, all kudzu treatments led to significant increases in soil enzyme activities and soil pH, SOC, NO3−-N, and AP concentrations in two rubber plantations. The TN and NH4+-N concentrations were significantly increased in mature rubber plantations, while the TP was the opposite.ConclusionThe kudzu returned can effectively alleviate soil acidic, improve soil nutrient availability, regulating soil enzyme activities of the rubber plantation in the short-term. These results provide a scientific basis for the rational application of kudzu in rubber plantations.
Assessment of agroforestry practices in Buno Bedele and Ilu Abba Bora zone of Oromia region, Ethiopia
Authors: Mezgebu Mosisa
Published: May 2023

Agroforestry practices are considered as one of the major source of food and income to meet the needs and the wellbeing of the rural community. This study was conducted in Buno Bedele and Ilu Abba Bora zone, with the aim to identify and assess agroforestry practice, constraints and Importance and farmers’ perception on the existing agroforestry practice in study area. Accordingly 3 districts from each zone and 12 Kebele in 6 districts were selected by purposely sampling methods and similarly 299 household were selected. Semi-structured questionnaire data was generated by conducting household survey interview, key informant, and direct field observation were applied. Based on the respondent’s idea across the both zones, the results of this study have shown that ,Homegardens (96%), Coffee based agroforestry practice (91.3) ,Fruit trees based agroforestry practice (86.6%), woodlot (65.6%), windbreak/shelterbelts (62.5%), Trees on rangeland (57.2%), Life fencing (53.8%), Parkland agroforestry (43.1%), Taungya (26.4%) and Alley cropping (16.7%) are the exist agroforestry practices in the study area. The major Importance of agroforestry practices were for income, regulated climates, soil improvement, used for shade, food and livestock feed, properly using the land, construction, fuel wood and timber. On the other hand, impacts of wild animals, Insect pest and disease, Competition trees with crop (i.e. shading effect), shortage of land for tree planting, lack of capital, lack of knowledge, taking long time for profit, lack of seed accessibility and Shortage of labor the major constraints recorded in the study areas. Majority of respondents were strongly agreed with the agroforestry practices; increase farm income, improve soil fertility and conserved soil and water, saved time on collecting fodder and fuel wood from the forest and improve the natural condition. Those show that the respondents in study area have positive attitude with existing agroforestry practices. Albizia gummifera (78.2%), Cordia africana (67.9%) and Croton macrostachyus (63.2%) were the most common trees that dominated in the study area. Albizia gummifera (67.2%) and Cordia africana (61.9%) also were most preferred trees by farmers in field. Avocado (91.3%), Banana (79.6%) and Mango (61.9%) were the most dominant fruit trees/shrubs, while Maize (95%), Coffee (91.3%), Teff (76.6%), Chat (65.9%) and Sorghum (52.8%) were the most dominant crops and Cow, Oxen, Calve, Chicken were the most dominant livestock. The study recommends further studies have to be done on positive interaction trees/shrubs selection in component, management and introducing new agroforestry practices and manage the exist agroforestry practice at study are.
In vivo deuterium magnetic resonance imaging of xenografted tumors following systemic administration of deuterated water
Authors: Brender Jeffrey R. , Assmann Julian C. , Farthing Don E. , Saito Keita , Kishimoto Shun , Warrick Kathrynne A. , Maglakelidze Natella , Larus Terri L. , Merkle Hellmut , Gress Ronald E. , Krishna Murali C. , Buxbaum Nataliya P.
Published: May 2023

In vivo deuterated water (2H2O) labeling leads to deuterium (2H) incorporation into biomolecules of proliferating cells and provides the basis for its use in cell kinetics research. We hypothesized that rapidly proliferating cancer cells would become preferentially labeled with 2H and, therefore, could be visualized by deuterium magnetic resonance imaging (dMRI) following a brief period of in vivo systemic 2H2O administration. We initiated systemic 2H2O administration in two xenograft mouse models harboring either human colorectal, HT-29, or pancreatic, MiaPaCa-2, tumors and 2H2O level of ~ 8% in total body water (TBW). Three schemas of 2H2O administration were tested: 1) starting at tumor seeding and continuing for 7 days of in vivo growth with imaging on day 7, 2) starting at tumor seeding and continuing for 14 days of in vivo growth with imaging on day 14, and 3) initiation of labeling following a week of in vivo tumor growth and continuing until imaging was performed on day 14. Deuterium chemical shift imaging of the tumor bearing limb and contralateral control was performed on either day 7 of 14 after tumor seeding, as described. After 14 days of in vivo tumor growth and 7 days of systemic labeling with 2H2O, a clear deuterium contrast was demonstrated between the xenografts and normal tissue. Labeling in the second week after tumor implantation afforded the highest contrast between neoplastic and healthy tissue in both models. Systemic labeling with 2H2O can be used to create imaging contrast between tumor and healthy issue, providing a non-radioactive method for in vivo cancer imaging.
Evidence for the Augmented Cd(II) Biosorption by Cd(II) resistant strain Candida tropicalis XTA1874 From Contaminated Aqueous Medium
Authors: Bhattacharyya Kaustav , Bhattacharjee Neelanjan , Ganguly Subhadeep
Published: May 2023

Cadmium is one of the most dreadful heavy metals and is becoming a major toxicant in ground water with increasing concentration above the WHO Guidelines in drinking water (0.003ppm). The conventional physico-chemical remediation techniques are not favorable in removing the contaminants such as Cd(II) fruitfully. Bio-based techniques used in Cd(II) removal from contaminated water provide cheap, eco-friendly and efficient means of environmental remediation. The present study is aimed at determining the optimized nutritional conditions for the optimal growth and Cd(II) remediation capacity for a developed Cd(II) resistant yeast strain named Candida tropicalis XTA 1874 isolated from contaminated water-body in West Bengal. By analyzing the optimization conditions, a synthetic medium was developed and the composition has been given in the main text. The biosorption process followed pseudo second order kinetics proving chemisorption as the rate limiting step in the adsorption process. The equilibrium biosorption of Cd(II) by the strain was fitted to the Langmuir model and hence the biosorption was a monolayer process both before and after optimization. The strain showed much better Cd(II) adsorption capacity under the optimized nutritional conditions (qmax=847.476±0.008 mg/g). The above findings amply demonstrated the strain to be an effective biosorbent in removing Cd(II) from contaminated water.