bluuebunny/crossref_metadata_2025 huggingface dataset:
Extracellular Vesicle (EV) Survivin for Cancer Diagnostics and Therapeutics: A Review
Authors: Wijaya Wynne , Phyu Su Myat , Jiang Shisong
Published: August 2024

Survivin, an important inhibitor of apoptosis protein, contributes to cancer cells’ resistance to apoptosis, proliferation, and survival. It is a promising biomarker and therapeutic target due to being highly expressed in cancer cells relative to normal cells and universally expressed in almost all cancer types. Cancer cells release survivin to the tumour microenvironment (TME) not only as a free protein but also encapsulated in extracellular vesicles (EVs), especially small EVs (sEVs). The release of encapsulated survivin from cancer cells can be taken up by neighbouring cells, eliciting pathological responses such as tumorigenesis and metastasis. Consequently, EV survivin holds potential as a diagnostic, prognostic, and therapeutic biomarker for several types of cancer, including breast cancer, prostate cancer, pancreatic cancer, and glioblastoma. EV survivin expression is significantly elevated in cancer patients and correlates with unfavourable clinicopathologic parameters. Although no clinical studies have explored EV survivin as a therapeutic target, future research should explore survivin-based therapies in combination with EV-targeting therapies to effectively disrupt its roles in tumorigenesis and metastasis.
Effects of Aerobic Exercise on Cardiopulmonary Function in Postoperative Patients with Congenital Heart Disease: A Meta-analysis
Authors: Guo Xiaozhen , Si Yanran , Liu Hairong , Yu Ling
Published: August 2024

Background: This meta-analysis aimed to evaluate the impact of aerobic exercise on Peak VO2 (Oxygen Consumption) in postoperative patients with congenital heart disease (CHD). Besides this, we also tried to discover whether the improvement was influenced by patient ages, modes of supervision, types of exercise, the total dose of exercise, intervention periods, and types of CHD. Methods: Following the Population Intervention Comparison Outcome Study Design (PICOS) principle, a comprehensive search of the PubMed, Web of Science, Embase and Cochrane Library databases was conducted for randomized controlled trials (RCTs) evaluating the intervention effects of aerobic exercise on cardiopulmonary function in postoperative CHD patients until December 2023. This meta-analysis and publication bias tests were conducted using Stata 17.0, and the mean differences (MDs) with 95% confidence intervals (CIs) were used as effect sizes in statistics. Results: A total of 15 RCTs (762 cases) were included in this meta-analysis, with 407 cases in the experimental group and 355 cases in the control group. Meta-analysis showed that aerobic exercise had a positive effect on Peak VO2 in postoperative CHD patients (MD = 2.14, 95% CI (1.34, 2.94), p < 0.00001, I2 = 36%). The analysis of subgroups showed that intervention effects of aerobic exercise were superior to the control group when patients were >18 years old (MD = 2.53, p < 0.00001), ≤18 years old (MD = 1.63, p = 0.01), under supervision (MD = 2.23, p < 0.00001), unsupervised (MD = 2.06, p < 0.00400), performing aerobic exercise (MD = 1.87, p = 0.0003), performing aerobic exercise combined with resistance training (MD = 2.57, p < 0.00010), with a total dose of exercise ≥1440 minutes (MD = 2.45, p < 0.00010), with the intervention period of 10–12 weeks (MD = 2.31, p < 0.00001), with that >12 weeks (MD = 1.97, p = 0.00300), or with mixed types of CHD (MD = 2.34, p < 0.00001). Conclusions: This meta-analysis did not deduct points for limitations, inconsistency, indirectness, imprecision, or publication bias, so the quality of evidence was graded as high. Aerobic exercise has a significantly positive impact on improving Peak VO2 in postoperative CHD patients. Moreover, it was found that for patients aged 18 and above, supervised aerobic exercise combined with resistance training, implemented for 10–12 weeks with a total dose of exercise ≥1440 minutes, had a better intervention effect on Peak VO2. This finding provided evidence-based medicine for the exercise rehabilitation of postoperative CHD patients, and explored the optimal exercise prescription for clinical practice as well. Clinical Trial registration: Registered on INPLASY No.202440016 (https://inplasy.com).
Left Pulmonary Vein Trunk Length as a Robust Predictor of Long-Term Success of Atrial Fibrillation Catheter Ablation
Authors: Li Jiaju , Wang Zhe , Qin Fen , Luo Fangyuan , Chen Jiawei , Liu Yankun , Tao Hailong , Dong Jianzeng
Published: August 2024

Background: Radiofrequency catheter ablation (RFCA) is a commonly used treatment for atrial fibrillation (AF), but the long-term recurrence rate remains relatively high. Given the inconsistent results regarding the role of left pulmonary vein (PV) ostial anatomy in post-ablative recurrence of RFCA in previous studies, we sought to investigate the role of left PV trunk length using an alternative methodology. Methods: A total of 369 AF patients undergoing catheter ablation were included. The left/right trunk length (LTL/RTL) of the PV was measured from pre-ablative computed tomography (CT) using three-dimensional reconstruction techniques. We constructed three multivariable Cox models, with the inclusion of the LTL, RTL, and no LTL/RTL, and used the Delong test, integrated discrimination index (IDI), and net reclassification index (NRI) to assess model improvement. We identified optimal cut-off values for LTL with the receiver operating characteristic (ROC) curve, and estimated outcomes using the Kaplan-Meier survival curve. We also used subgroup analysis to evaluate interactions. Results: The results of the Delong test, IDI, and NRI indicated that LTL had a favorable impact on the performance of the multivariate model. Subsequently, the multivariate Cox regression analysis identified LTL as a significant risk factor for post-ablative recurrence of AF (adjusted hazard ratio (HR) = 1.08, 95% CI: 1.05–1.12, p < 0.001). According to the ROC curve, the optimal cut-off value for LTL is 11.15 mm, and the Kaplan-Meier estimator revealed different outcomes (p < 0.001). We calculated p for interaction between LTL and other factors, and no significant interaction terms were observed. Conclusions: LTL is a robust prognostic indicator for post-ablative outcome in AF patients receiving RFCA, with a longer LTL indicating a higher risk of recurrence.
Idiopathic Ventricular Fibrillation — Just How Much Idiopathic is it?
Authors: Lietava Samuel , Sepsi Milan , Novotny Tomas
Published: August 2024

Idiopathic ventricular fibrillation is diagnosed in survivors of sudden cardiac death that has been caused by ventricular fibrillation without known structural or electrical abnormalities, even after extensive investigation. It is a common cause of sudden death in young adults. Although idiopathic ventricular fibrillation is a diagnosis of exclusion, in many cases only a partial investigation algorithm is performed. The aim of this review is to present a comprehensive diagnostic evaluation algorithm with a focus on diagnostic assessment of inherited arrhythmic syndromes and genetic background.
Perancangan dan Pengembangan UI/UX Pada Platform Tenderplus.id Menggunakan Metode Design Thinking
Authors: Ashari Wahid Miftahul , Sunu Pamungkas Hanfazano Rahmadimasti , Asharudin Firman , Sismoro Heri
Published: August 2024

Tenderplus.id adalah sebuah platform pengadaan barang dan jasa yang bertujuan untuk mempermudah kegiatan lelang pengadaan barang dan jasa. Proses lelang ini sering kali memakan waktu dan sumber daya yang besar. Dengan memperhatikan permasalahan ini, penulis mengembangkan platform ini dengan desain yang bertujuan untuk menyelesaikan kendala-kendala yang ada. Pada penelitian ini, penulis menggunakan metode Design Thinking, sebuah pendekatan kreatif untuk menangani masalah kompleks dan merancang solusi yang inovatif. Metode ini juga melibatkan pengguna sehingga perspektif mereka dapat diakomodasi. Proses Design Thinking meliputi langkah-langkah Empathize: Memahami dengan empati masalah yang dihadapi pengguna, Define: Menguraikan dan menganalisis masalah inti, Ideate: Menghasilkan solusi untuk masalah pengguna, Prototype: Membuat versi produk berupa desain mockup, Tes: Menguji desain untuk mendapatkan hasil yang optimal, Iteration: umpan balik dari pengujian. Hasil dari penelitian ini berupa prototipe website dan desain UI/UX yang berfungsi sebagai dokumentasi pengembangan platform Tenderplus.id.
ABANDONO Y REPROBACIÓN ESCOLAR EN EL NIVEL MEDIO SUPERIOR DE LA UNIVERSIDAD AUTÓNOMA DEL ESTADO DE MÉXICO: complejidad de un fenómeno multifactorial y contribuciones a la orientación educativa
Authors: Gutiérrez Gómez Rubén , Mondragón Espinoza Blanca Aurora , Carmona Zepeda María de los Ángeles , Arriaga Álvarez Emilio Gerardo
Published: August 2024

El escrito aborda teórica y conceptualmente, el problema del abandono y la reprobación escolar, en tanto problemáticas educativas interrelacionadas que no se pueden ver independientes. El abordaje teórico que se realiza de ambos conceptos, muestra la cantidad de factores que intervienen en su conformación, lo cual muestra la complejidad de su comprensión y atención en el campo escolar, así como el carácter polisémico que diferentes estudios y autores otorgan particularmente al abandono escolar. Al final del escrito se exponen datos empíricos de la situación en la Escuela Preparatoria de la UAEM, con la intención de contextualizar su problemática en la institución y como un primer avance empírico del estudio, además de comentar el papel de la orientación educativa en la atención de dicho fenómeno. Palabras clave: Abandono escolar, reprobación, calidad educativa, bachillerato, investigación documental, orientación educativa.
Two-dimensional Ekman-Inertial Instability: A comparison with Inertial Instability
Authors: Trujano-Jimenez Fabiola , Zemskova Varvara , Grisouard Nicolas
Published: August 2024

In the ocean, submesoscale flows tend to undergo several hydrodynamic instabilities. In particular, Inertial Instability (InI) and Ekman-Inertial Instability (EII) are known to develop in geostrophically balanced barotropic flows whose lateral shear is larger in magnitude and opposite in sign to the Coriolis parameter. Although these instabilities share some elements, their dynamical nature can lead to fundamental differences. However, the current analytical description of EII is one-dimensional, which makes it difficult to compare against InI in a more realistic scenario. To overcome this limitation, we conduct two-dimensional numerical simulations of both InI and EII in a submesoscale jet and explore the induced vertical flow, the growth rate, and the energetics of each instability. Furthermore, we investigate the sensitivity of our results to variations in the minimum Rossby number of the jet. We find that EII grows faster than InI and induces stronger vertical flow, especially near the surface. Both instabilities radiate inertial waves away from the current, and these waves predominantly propagate across the anticyclonic side of the jet. Finally, when the instabilities weaken, the fluid reaches a stable state that is remarkably similar in both cases. This study highlights the similarities and differences between InI and EII and provides further insight into the mechanism behind EII that makes it capable of outcompeting other submesoscale instabilities.
Ranking
Authors: Brankovic Jelena , Wilbers Stefan
Published: August 2024

The term “ranking” (or, more often, “rankings”) is usually understood as a hierarchy of higher education institutions, which is expected to indicate differences in their quality as educational and scientific organizations. These rankings first emerged around the turn of the twentieth century and were initially produced by scientists and academic administrators, yet they rarely reached beyond academic circles. Their influence on administrators, faculty, students, policymakers, and the higher education sector as a whole—all over the world—has been extensively documented, studied, debated, and puzzled over. But how have some seemingly simple lists come to be so important? In contrast with most literature grappling with the question, which typically sees the history of rankings in higher education as a succession of "successful" publications, we argue that the history of ranking institutions of higher education is characterized by a much higher degree of continuity than it is often assumed.
The Public that Engages Invisibly: What Visible Engagement Fails to Capture in Online Political Communication
Authors: Chen Yijing , Kmetty Zoltan , Iniguez Gerardo , Omodei Elisa
Published: August 2024

Measurements of political polarization online have so far been largely focused on visible traces accessible through platformAPIs,while neglecting invisible traces not recorded or otherwise unavailable via online channels, which can reveal key aspects of political engagement online. Our study aims to address this gap by investigating the polarization measurement bias that arises when only visible engagement is considered. Using a combined dataset that links survey responses with YouTube digital traces froma representative sample of Hungarian Internet users (N=758), we uncover disparities at both user and channel levels.We find that users who visibly engage through commenting are more politically polarized. People tend to comment and subscribe to ideologically concentrated content, while viewingideologically diverse content. We also notice that ideologically heterogeneous channels are more likely to share viewers than subscribers or commenters. Thus, the segregation ofpolitical channels may be overstated or simplified when relying solely on public comment data. Our results suggest that research using only visible engagement may overestimate the extent of polarization and the prevalence of echo chambers online. We highlight the benefits of data donation to address measurement bias in online political communication, and contribute to the polarization literature by providing a fresh evaluation of potential biases in platform-focused research.
Evidence Communication Rules for Policy (ECR-P) critical appraisal tool
Authors: Danopoulos Evangelos , Aston John , Shah Aarushi , Schneider Claudia R.
Published: August 2024

Scientific papers are increasingly putting forward policy recommendations thus closing the circle of science, policy and practice. Quality appraisal of scientific-based policy recommendations is crucial, whether within the context of a systematic review or not. The ECR-P (Evidence Communication Rules for Policy) critical appraisal tool is used to assess the quality of both the recommendations and their evidence base putting policymakers, as the end users, centre stage. This tool was developed by a diverse group of researchers and stakeholders, taking into account existing critical appraisal tools. ECR-P is structured in five domains, based on the five rules of evidence communication. The domains include 25 signalling questions addressing aspects of internal and external validity as well as quality of communication. Domain-based judgment is derived from responses to the signalling questions and an accompanying algorithm, followed by overall quality judgement. ECR-P provides a focused, standardized and transparent approach to assessing the quality of scientific-based policy recommendations in any scientific field. ECR-P critical appraisal tool was designed to fit with the systematic reviewing process but also as a stand-alone tool. Besides review assessors, it can also be used by policymakers and policymaking organizations, peer-reviewers and journal editors and any other stakeholders interested in evidence-based policymaking.
An Influence of the English Language over the Nepali Language (Regarding KTM Metropolitan ward no 09)
Authors: Singh Daman Bahadur , Lamichhane Basu Dev
Published: August 2024

Since the 18th century, Nepal, a multilingual, multicultural, and multiethnic nation, has been impacted by the movement, network, and interdependence of globalization. This research highlighted the complex issues of language contact and the sociolinguistic outcomes of that interaction, with a particular emphasis on how English has influenced the Nepali language. The objectives of this research were to identify different factors that help to influence the English language over the Nepali language and the second objective is to Investigate the Influence of the English language on Nepalese society. The main research problem was the influence of The English language over the Nepali language. To solve this research problem different questions were raised which are i) How did the English language influence Nepalese society? ii) What are the different reasons for the growing popularity of the English language in Nepali society? In this research positivist research paradigm was adopted. A descriptive research design was applied to conduct research activities. The population of the study was conveniently selected. The total population of Kathmandu Metropolitan Ward no. 9 is 40371 was the population of this study. The sampling design was the probability sampling design. The sample size was determined by applying Slovine 's rule. The sample size was 400 and sampling units were selected by multi-stage random sampling. Primary and secondary sources of data were used to collect data with the help of structured questionnaires. Data were analyzed with the help of frequency and percentage. After analysis, it was found that the English language influence over the Nepali language. Different factors that were caused to influence the Nepali language were identified and different influencing factors were also identified. The majority of Nepali people usethe English language in their daily administrative work like Admission forms, Bank accounts, Voucher Fillup, Application Submission, Passport form fill-up,and Others respectively, 81%, 86%, 91%, 97%, and 86%, and 87%. Below 10,10-20, 20-30, 30-40, 40-50, 50-60, 60 and above are using daddy, mummy, uncle, anti in100%, 94.45%, 79%, 81%, 21.7%, 25%, 0% Others were found to use the English language in different mentioned administrative works. Age groups below 40 years 100% used English words while talking in Nepali with their friends and cousins In the same way age group below 40 years mostly watched English programs on TV.  the investigation also showed that an age group below 40 years used The English language while chatting on social media like Facebook Messenger, Instagram, Viber, etc. In this research With this rapid speed influence the English language is going ahead, after a few decades there will be no Nepali language, and it will lose its identity. There will be erosion in Nepali culture, tradition, and values.
Preparedness of Nepalese Academia for Society 5.0: A Study on Human Resources and Technology Transformation
Authors: Rijal Rheet
Published: August 2024

The present study applied a positivist-deductive approach with a causal-comparative research design, using purposive convenient sampling to select four hundred and thirty three participants from different Nepalese academic institutions. An online platform facilitated the administration of a meticulously structured data collection instrument, i.e., structured questionnaire.  Descriptive and inferential statistical analysis using SPSS software 24 was conducted. Validity and reliability tests were performed with Amos 22, offering empirical insights into the preparedness of Nepalese academia for the Society 5.0 paradigm shift, which allowed for an in-depth examination of the preparedness of Nepalese educational institutions, contributing to theoretical insights and practical understanding of the interplay between human resources and technology integration. Findings revealed a low level of preparedness among Nepalese academia for transitioning to Society 5.0, particularly in human resources and technology integration. Application of technology in recruitment processes enhanced efficiency and reduced time-to-hire, aligning with Society 5.0 goals.
However, a significant gap in digital literacy among faculty members was identified, highlighting the need for resources and training programs to facilitate technology integration into teaching methodologies. Nevertheless, institution advocates for its faculty to adopt innovative teaching methods such as blended learning and flipped classrooms, which are crucial for providing experiential learning opportunities in alignment with Society 5.0 principles. The study provides valuable insights for educational leaders, universities, and policymakers aiming to enhance institutional preparedness for Society 5.0, enriching an understanding of factors influencing preparedness and laying a foundation for impending research in the context of technological and educational advancements in Nepalese Academia.
Microsatellite analysis of pea varieties with contrasting protein content in seeds
Authors: Gainullina К.P. , Slinkin A.A.
Published: August 2024

The article considers the problem of searching for associations of allelic variants of microsatellite loci with protein content in pea seeds. Among all leguminous crops characterized by high protein content, pea is the most adaptive crop to the conditions of the Urals steppe zone of the Republic of Bashkortostan. Its cultivation is promising in this territory. To identify allelic variants that can be used in the future as DNA markers of high content of reserve seed proteins (legumin, vicilin, convicilin), genotyping of varieties and lines of seed pea of different ecological and geographical origin was carried out. According to the Bradford method, the content of total protein in the studied cultivars was determined, and cultivars contrasting in this trait were identified. Two groups of samples with high (23.5±0.4 - 26.1±0.5%) and low (18.0±0.3 - 19.7±0.3%) protein content were formed. Then, genotyping of the above groups was performed by SSR analysis. As a result of the applied methodology, information on allelic composition of varietal samples with high and low content of spare seed proteins was obtained. The obtained data are planned to be used as additional criteria for selection of parental forms in crosses to obtain high-protein hybrids.
Pengaruh Karakteristik Terhadap Pendampingan Asi Perah (Damaserah) Mewujudkan Keberhasilan Asi Ekslusif Di Kabupaten Sidenreng Rappang
Authors: Hamdiyah Hamdiyah , Nurbaya Nurbaya , Laela Nur , Resmawati Resmawati , Rusdiana Rusdiana
Published: August 2024

The content in breast milk has very complete nutrition and contains antibodies that help build the immune system for the growth and development of the baby. Characteristics of mothers that can influence the success of exclusive breastfeeding include age, education level, occupation and parity. Exclusive breastfeeding is giving only breast milk until the baby is 6 months old. Based on the test of the subject of this study, pregnant women in the last trimester were then provided with assistance regarding expressed breastfeeding and monitoring for 6 months. The sample of this research was breastfeeding mothers 0-6 months as many as 30 respondents in Sidenreng Rappang Regency. Based on the independent t test and paired t test to see the effect of the characteristics of breastfeeding assistance on the success of exclusive breastfeeding, namely based on characteristics of age (value 0.591), occupation (value 0.432), education (value 0.190), parity (value 0.186). The conclusion in this study is that there is no characteristic relationship to breastfeeding assistance. Basically the success of exclusive breastfeeding depends on the belief, strong determination and the mother's own decision.Kandungan dalam ASI memliki nutrisi yang sangat lengkap dan mengandung antibodi yang membantu dalam membangun sistem kekebalan untuk pertumbuhan dan perkembangan bayi. Karakteristik ibu yang dapat mempengaruhi keberhasilan ASI Eksklusif tersebut berupa usia, tingkat pendidikan, pekerjaan dan paritas. ASI Eksklusif adalah pemberian ASI saja sampai bayi berusia 6 bulan. Berdasarkan uji Subjek penelitian ini ibu hamil trimester akhir, kemudian dilakukan pendampingan tentang ASI Perah dan dilakukan pemantauan selama 6 bulan. Sampel penelitian ini adalah ibu menyusui 0-6 bulan sebanyak 30 responden di Kabupaten Sidenreng Rappang. Berdasarkan uji independent t test dan paired t test untuk melihat pengaruh karakteristik pendampingan ASI Perah terhadap keberhasilan ASI Eksklusif yaitu berdasarkan karakteristik umur (nilai 0.591), pekerjaan (nilai 0.432), pendidikan (nilai 0.190), paritas (nilai 0.186). Adapun kesimpulan pada penelitian ini tidak ada hubungan karakteristik terhadappendampingan ASI Perah. Pada dasarnya keberhasilan ASI Eksklusif tergantung atas keyakinan, tekat yang kuat dan keputusan ibu sendiri.
Hubungan Pola Pemberian Asi Eksklusif Terhadap Status Gizi Anak 6-59 Bulan Di Wilayah Kerja Puskesmas Tilango Kabupaten Gorontalo
Authors: Zakaria Fatmah , Rauf Efri Leny , Zakaria Taflin
Published: August 2024

Hubungan pola pemberian asi eksklusif terhadap status gizi anak 6-59 bulan di Wilayah kerja Puskesmas Tilango Kabupaten Gorontalo. Penelitian ini bertujuan untuk mengetahui Hubungan Pola Pemberian ASI eksklusif terhadap status gizi anak 60-59 di Puskesmas Tilango Kabupaten Gorontalo. Jenis penelitian ini adalah Observasional analytic dengan menggunakan pendekatan cross sectional. Sampel dalam penelitian ini berjumlah 307 responden balita di Wilayah Kerja Puskesmas Tilango pada bulan Agustus sampai bulan September tahun 2017, dengan tekhnik pengambilan sampel menggunakan simple random sampling. Hasil analisis uji statistik chi square dengan tingkat kemaknaan α= 0,05 di dapatkan χ2hitung > χ2tabel (99,800 > 5,591) maka Ho ditolak yang berarti ada hubungan antara pola pemberian ASI eksklusif terhadap status gizi anak 6-59 bulan.
Pengaruh Penggunaan Bengkung Terhadap Penurunan Lingkar Perut Ibu Post Partum di Puskesmas Kassi-Kassi
Authors: Sumarni Sumarni , Nahira Nahira
Published: August 2024

Pada masa nifas proses involusi uterus menjadi salah satu parameter pengukuran pemulihan pada masa nifas yang akan berdampak pada morbiditas dan mortalitas ibu. Penggunaan bengkung menjadi salah satu alternatif yang digunakan untuk mengencangkan otot perut dan membantu mempercepat pemulihan rahim ke bentuk semula. Sehingga pada akhirnya akan membantu agar otot abdomen bekerja lebih sempurna. Tujuan penelitian ini mengetahui pengaruh penggunaan bengkung terhadap penurunan lingkar perut ibu post partum di Puskesmas Kassi-Kassi. Penelitian ini menggunakan desain quasi eksperiment dengan menggunakan pendekatan pre test dan post test design. Jumlah sampel sebanyak 30 sampel dimana Teknik pengambilan sampel menggunakan purposive sampling yaitu dipilih berdasarkan kriteria yang telah ditentukan. Dari hasil uji SPSS penurunan lingkar perut pada responden sebelum dilakukan intervensi diperoleh nilai rata-rata pretest 84, 44 cm dan setelah perlakuan dengan nilai 82.12 cm. Hal ini menunjukkan ada penurunan lingkar perut setelah penggunaan bengkung dari nilai p-value 0,032 dengan mengunakan uji paired T-Test. Dari hasil pengukuran kelompok intervensi dan kelompok kontrol diperoleh hasil p-value 0.036 menggunakan uji T Independent dimana hasil ini menunjukkan adanya Pengaruh Penggunaan Bengkung Terhadap Penurunan Lingkar Perut Ibu Post Partum Di Puskesmas Kassi-Kassi.
Hubungan Mengonsumsi Makanan Cepat Saji (Fast Food) Dengan Kejadian Dysmenorrhea Pada Remaja Putri
Authors: Simbung Rismawati , Ohorella Fadjriah , Metasari Nova Ulfa
Published: August 2024

Fast food is generally preferred by teenagers, as well as adults because it tastes according to taste and is affordable. In a broad sense, fast food actually includes all types of food that can be served quickly. The presence of fast food greatly affects the diet of teenagers in big cities. It is undeniable that with a practical city lifestyle, teenagers find it difficult to avoid fast food. The purpose of this study was to find the relationship between fast food consumption and the incidence of primary dysmenorrhea in adolescent girls at SMA Negeri 12 Makassar in 2020. In this study, samples were taken from 35 young women used Accidental Sampling technique. The results showed that from 35 respondents as samples, 21 people used fast food (60.0%) and 14 people did not use fast food (40.0%). The results showed that of the 35 respondents who were sampled, 19 people had dysmenorrhea (54.3%) and 16 people did not experience dysmenorrhea (45.7%). The results showed that there was a relationship between consumption of fast food and the incidence of primary dysmenorrhea in female adolescents at SMA Negeri 12 Makassar
Efektivitas Pemberian Buah Bit (Beta Vulgaris Subsp.) Terhadap Anemia Pada Ibu Prakonsepsi
Authors: Sampara Nurqalbi , Muzakkir Muzakkir
Published: August 2024

Preconception is a critical period for every woman of childbearing age (WUS), which determines the quality of the baby born. Researcher Objectives This study aims to determine the effectiveness of giving beet fruit (Beta et al.) on Anemia in Preconception Mothers in the Tanakaraeng Village Working Area. This research design uses a Quasi-Experimental design with a Pretest-Posttest With Control design with a nonequivalent control group design method, namely before being given both the experimental and control groups. Based on the unpaired T-test statistical test (independent sample T-test). It was found that the significant value of 0.003 was smaller than 0.05. There is a significant difference in the results of the study because the significant value is smaller than 0.05, and it can be seen that the average value or mean in the post-test giving beetroot fruit is 11.6, and in the post-test giving Fe tablets is 10.6. This value means that the average giving of beet fruit with Fe tablets is higher than that of Fe tablets. Pregnant women are expected to consume foods with high iron content.
Implementasi Program Bantuan Kartu Penyandang Disabilitas Jakarta di Kelurahan Jatinegara
Authors: Ruswanto Mohammad , Utama Dedy Kusna
Published: August 2024

This study discusses the implementation of the Jakarta Disability Card assistance program in Jatinegara. The aim is to find out the extent of the implementation of the assistance program for persons with disabilities in the area. This study used George C Edward III’s which suggests that the implementation of public policy is influenced by four aspects, namely communication, resources, attitudes and bureaucratic structure. Data was collected through interviews, documentation, and literature studies to support analysis and observation to find out firsthand the actual situation. The results showed that in terms of the formulation of the research problem, the card assistance program for persons with disabilities in the Jatinegara area had been implemented quite well and significantly. However, it is necessary to make more improvements to facilities and infrastructure as well as resources.

Abstrak

Penelitian ini adalah penelitian mengenai implementasi program bantuan kartu penyandang disabilitas Jakarta di Kelurahan Jatinegara. Tujuan penelitian ini adalah untuk mengetahui sejauh mana implementasi program bantuan penyandang disabilitas ditempat tersebut. Penelitian ini menggunakan teori George C Edward III yang mengemukakan implementasi kebijakan publik dipengaruhi oleh 4 aspek yaitu komunikasi, sumber daya, sikap dan struktur birokrasi. Metode pengumpulan data dengan pedoman wawancara, dokumentasi, dan studi litelature untuk mendukung analisa dan observasi untuk mengetahui secara langsung keadaan yang sebenarnya. Hasil penelitian menunjukan implementasi program bantuan kartu penyandang disabilitas di kelurahan Jatinegara setelah ditinjau dari rumusan permasalahan penelitian, maka dalam pengimplementasiannya sudah cukup baik dan signifikan, namun harus lebih banyak lagi improvisasi untuk sarana dan prasarana maupun sumber daya yang ada.
Osteoporosis Management in Patients with Hip Fracture post Fall
Authors: Guo Yang , Xu Ying Hua , O'Rourke Fintan , Zhang Evan
Published: August 2024

Introduction:

Osteoporosis increases the risk of fragility fracture. Hip fractures are associated with poor outcomes. Men are under-screened and under-treated for osteoporosis, which tends to be secondary, and men have higher mortality and worse outcomes after hip fracture than do women. This study aimed to describe patients admitted with hip fracture following minimal trauma and to explore any gender differences in calcium and vitamin D deficiency and use of osteoporosis medication before admission.

Methods:

A retrospective cross-sectional study included all patients admitted to Bankstown-Lidcombe Hospital with a fracture of the hip post fall, with or without surgery, from January 1, 2019, to December 31, 2019. Each patient's electronic medical record was reviewed to collect data. The data were extracted and analysed using GraphPad Prism 9.5.1. Unpaired Student's t-tests and Fisher's exact test were used in the analysis.

Results:

A total of 203 patients were included with a mean age of 83.5 ± 8.8 years and a range of 40 to 103 years, with over half (51.2%) aged 81 to 90 years. Fifty-nine (29.1%) were male. Of 196 patients with vitamin D levels available, 78 (39.8%) had a deficiency, including 30 of 57 (52.6%) males and 48 of 139 (34.5%) females. Males were twice as likely to be vitamin D deficient as were females on admission (OR 2.106; 95% CI 1.143 to 3.939; p = 0.0243). Of 203 patients, 39 (19.2%) were on osteoporosis treatment before admission, including 6 of 59 (10.2%) male and 33 of 144 (22.9%) female patients. Males were 2.6 times more likely to have had no osteoporosis treatment before admission than were females (OR 2.626; 95% CI 1.059 to 6.340; p = 0.0486).

Conclusions:

Males were more likely to have vitamin D deficiency and not be prescribed osteoporosis medication before admission in a cohort of patients admitted to the hospital with hip fracture post minimal trauma. To prevent hip fracture and resultant hospitalization, increased awareness is needed in diagnosing and managing osteoporosis in men, ideally occurring in the community.
النظام السياسي والسعي للشرعية
Authors: روثرفورد بروس
Published: August 2024

تناقش هذه الدراسة مفهوم الشرعية وأنماطها في مصر منذ عام 2013 ، وشرعية الأداء في مجال السياسات التعليمية، والإسهام الذي تضطلع به هذه الشرعية في ديمومة النظام. وتبين أن النظام لا يستطيع صنع شرعيته؛ إذ لا يمكنه أن يبعث إلى الوجود وهمًًا بالأداء الجيد، لكنه قادر على إدارتها في جوانب كثيرة؛ منها صوغ التوقعات العامة عنه بالتشديد على أهمية الحفاظ على النظام العام وتوفير السلع والخدمات الأساسية، وتأكيد إنجازاته وحجب إخفاقاته وقمع الانتقادات التي قد تُُوجََّه إليه. ويمكنه أضًيًا إدارة مدركات المواطنين عن البدائل الممكنة التي تتمثل في الإسلاميين، أو الانزلاق إلى الفوضى، أو الاثنين معًًا. وتخلص الدراسة إلى أن هدف النظام ليس الحصول على دعم شعبي حقيقي، بل تحقُُّق الإذعان العام له من خلال إقناع غالبية السكان بأنه الأفضل من أي بديل آخر.
"الاستراتيجية الصينية تجاه الدول العربية: الأهداف والآثار المستقبلية، دراسة استشرافية
Authors: لحنين ياسمين
Published: August 2024

عنوان الكتاب: الاستراتيجية الصينية تجاه الدول العربية: الأهداف والآثار المستقبلية، دراسة استشرافية
المؤلف: أنس خالد نصار
سنة النشر: 2020 .
الناشر: الدوحة/ بيروت: المركز العربي للأبحاث ودراسة السياسات.
عدد الصفحات: 275 صفحة.
Heavy metal blood levels and their age-dependent changes in patients undergoing hemodialysis at Jordan Islamic Hospital
Authors: Abu Orabi Faten M. , Fawzi Mohammad , Humaidi Jamal , Shammout Mohammad-Jamal , Saleh Rawand , Hakawati Hedaya , Abu-Rayyan Ahmed
Published: August 2024

End-stage kidney disease (ESKD) is increasingly recognized as a major global health issue. Heavy metal exposure is a significant risk factor for ESKD. The present study aimed to assess the blood levels of cadmium (Cd), lead (Pb), copper (Cu), and zinc (Zn), and to investigate their variations with age among patients undergoing hemodialysis (HD).
Methods. A cross-sectional study was conducted in Amman, Jordan, from January to December 2023. The study included 80 ESKD patients undergoing hemodialysis and 80 healthy controls, both groups aged 20-60 years, divided into four age ranges: 20-29, 30-39, 40-49, and 50-60 years. Blood samples were analyzed for Pb, Zn, Cd, and Cu using atomic absorption spectrometry. Data were analyzed using ANOVA, and p-values <0.05 were considered significant.
Results. The concentrations of Pb, Cd, and Cu were significantly higher in ESKD patients compared to healthy controls, while Zn levels were notably lower in ESKD patients. Specifically, Pb levels averaged 27.65 µg/dL in ESKD patients versus 1.06 µg/dL in controls (p = 0.006). Cd levels averaged 1.035 µg/dL in ESKD patients versus 0.0485 µg/dL in controls (p = 0.008). Cu levels averaged 270.1 µg/dL in ESKD patients versus 81.8 µg/dL in controls (p = 0.004). Zn levels were significantly reduced in ESKD patients, averaging 29.5 µg/dL compared to 82.45 µg/dL in controls (p = 0.035). Age-dependent variations showed that Pb (p = 0.01 ), Cd (p = 0.043), Cu (p = 0.01), and Zn (p = 0.037 ) levels increase with age in ESKD patients, suggesting age-related differences in metal accumulation and metabolism.
Conclusion: This study highlights significantly elevated levels of Pb, Cd, and Cu, and reduced Zn levels in ESKD patients undergoing hemodialysis compared to healthy controls. Age-dependent differences in metal concentrations suggest that the accumulation and metabolism of these metals may be influenced by age in ESKD patients. These findings underscore the need for further research into the impact of environmental toxins on kidney health.
Natriuretic peptides and their association with renin, aldosterone, and electrolytes in hypertension: A cross-sectional study
Authors: Mohammed Amna Adil , Salman Maryam I.
Published: August 2024

Despite the extensive prevalence of hypertension and its established role as a leading risk factor for various heart diseases, there remains a significant gap in understanding the intricate mechanisms and physiological markers involved in the condition. Although natriuretic peptides are known to regulate numerous physiological processes, their precise relationship with other physiological variables such as resistin, renin, aldosterone, and electrolytes in individuals with hypertension has not been thoroughly investigated. The present study aimed to evaluate the levels of natriuretic peptides and their correlation with some physiological variables, such as resistin, renin, aldosterone, sodium, potassium, and chloride in hypertensive patients.
Methods. This cross-sectional study recruited 90 participants (50 hypertensive patients and 40 healthy volunteers as controls) between the ages of 30 and 50. The blood samples were collected from all the participants between December 2023 and April 2024 at Al-Ramadi Teaching Hospital. Serum levels of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), C-type natriuretic peptide (CNP), renin, resistin, aldosterone, potassium, sodium, and chloride were measured.
Results. The results showed that the concentration of ANP, BNP, and CNP was significantly higher (p < 0.001) in the hypertensive group compared with the control group. Renin, resistin, sodium, and chloride concentrations in the hypertensive group were significantly higher (p < 0.001) than in the control group. Conversely, potassium levels were significantly lower (p < 0.001) in the hypertensive patient group compared with the control group. There was a positive correlation between ANP with resistin and renin r=0.500, 0.505 respectively, while there is a negative correlation between ANP wilt sodium and chloride r= -0.321, r= -0.297 respectively, a positive correlation was observed between BNP and renin (r= 0.316), and aldosterone (r=0.395).
Conclusions. The present study discovered that patients with hypertension experienced increased levels of natriuretic peptides, resistin, renin, and aldosterone, as well as a decline in the concentration of electrolytes. The observed associations between natriuretic peptides and certain physiological variables, such as resistin and renin, sodium, and chloride, highlight interconnected pathways involved in hypertension. This suggests that natriuretic peptides may be used as a treatment for hypertensive patients.
Смертність у хворих на ХХН VГД з постковідним синдромом: багатоцентрове, проспективне, когортне дослідження
Authors: Kolesnyk Mykola , Stepanova Natalia , Ostapenko Tetyana , Snisar Lyudmyla , Rysev Andriy , Shifris Iryna
Published: August 2024

Термінальна стадія хронічної хвороби нирок, яка потребує лікування методом гемодіалізу (ХХН VГД), є критичною глобальною проблемою охорони здоров'я, яка ще більше ускладнилась пандемією COVID-19. Хоча відомо, що постковідний синдром (ПКС) погіршує якість життя ГД пацієнтів, його вплив на смертність залишається маловивченим. Метою цього дослідження було проаналізувати смертність хворих на ХХН VГД з ПКС та визначити її клінічні та лабораторні детермінанти.
Методи. Це багатоцентрове, проспективне дослідження включало ГД пацієнтів з чотирьох діалізних центрів України, які перенесли COVID-19 станом на кінець березня 2022 року. Зібрані дані включали демографічні, клінічні та лабораторні параметри і наявність ПКС. Основними кінцевими точками були смертність у хворих, асоційована з ПКС або без нього.
Результати. З 465 ГД пацієнтів, 353 відповідали критеріям включення. ПКС був діагностований у 222 пацієнтів (62,9%), який асоціювався з чоловічою статтю, старшим віком, діабетом, тимчасовим судинним доступом, вищим індексом Чарлсона, нижчими показниками Kt/V, гемоглобіну та альбуміну, вищими балами CONUT та підвищеними рівнями СРБ. Протягом двох років спостереження зареєстровано 38 (11,4%) летальних випадків; основними причинами смерті були серцево-судинні події (42,2%) та інфекційні ускладнення (21,1%). Багатофакторний регресійний аналіз Кокса визначив, що старший вік (OR 1,32, 95% CI 1,03; 1,66), тривалість діалізу (OR 1,86, 95% CI 1,77; 1,97), діабет (OR 3,57, 95% CI 1,81; 7,06), вища коморбідність (OR 4,22, 95% CI 2,11; 7,82), гірший нутритивний статус (OR 1,66, 95% CI 1,08; 12,3), тимчасовий судинний доступ (OR 1,88, 95% CI 1,16; 3,86), високий артеріальний тиск (OR 1,37, 95% CI 1,03; 1,82) та рівень С-реактивного білка (OR 1,68, 95% CI 1,49; 1,95) і тяжкий перебіг COVID-19, який вимагав госпіталізації (OR 5,7, 95% CI 3,73; 7,89), є незалежними предикторами смертності. У той же час, цільові рівні гемоглобіну (OR 0,87, 95% CI 0,66; 0,99) та Kt/V (OR 0,74, 95% CI 0,68; 0,96), а також вакцинація проти COVID-19 (OR 0,17, 95% CI 0,05; 0,61) статистично значущо знижували імовірність смерті. Наявність ПКС не впливала на виживаність ГД пацієнтів протягом двох років.
Висновки. Дворічна смертність ГД пацієнтів з ПКС визначається комбінацією демографічних та клініко-лабораторних факторів, таких як старший вік, тривале лікування ГД, коморбідна патологія, білково-енергетична недостатність, тимчасовий судинний доступ, неадекватна діалізна доза, низькй рівень гемоглобіну, хронічне запалення, недосягнення цільового рівня артеріального тиску, негативний вакцинальний статус та тяжкий перебіг гострого періоду COVID-19 з необхідністю кисневої підтримки. Вакцинація та підтримання цільових рівнів показників моніторингу хворих на ХХН VГД після COVID-19 мають вирішальне значення для покращення виживання цієї категорії хворих.
Analisis Kemampuan Berpikir Kreatif Matematis Siswa pada Materi Segi Empat dan Segitiga di Kelas VIII SMP
Authors: Betti Triwarsana  , Marhadi Saputro
Published: August 2024

This study aims to analyze the mathematical creative thinking ability of grade VIII students in solving quadrilateral and triangle problems in one of the swasta junior high schools in Pontianak. This research used descriptive method with qualitative approach. Data were collected through essay tests and interviews to provide an overview of students' mathematical creative thinking ability. The results showed that 21.28% of students were in the low ability category, with scores below the difference between the mean and standard deviation of students' scores. In the medium category, 61.7% of students scored above or equal to the low group score criteria but below the high group score criteria. Meanwhile, 17.02% of students were in the high category, with scores above or equal to the sum of the mean and standard deviation of student scores. Analysis of the indicators of creative thinking ability shows that students have very good abilities in the indicators of fluency, flexibility, and elaboration. However, in the originality indicator, students are still in the good category. These findings indicate the need for improvement in the originality aspect of students' creative thinking to achieve more optimal results in mathematical problem solving.
Inteligencia artificial generativa en la educación superior: usos y opiniones de los profesores
Authors: Perezchica-Vega José Eduardo , Sepúlveda-Rodríguez Jesuán Adalberto , Román-Méndez Alan David
Published: August 2024

Introducción: La inteligencia artificial generativa (IAG) ha suscitado gran interés en el ámbito educativo, así como preocupaciones sobre su mal uso. Este estudio exploró las inquietudes de los docentes sobre su uso, cómo la han utilizado ellos, las medidas preventivas que adoptan y su formación en el tema. Metodología: Se realizó una investigación de tipo cuantitativa, no experimental, de tipo transversal, con alcance exploratorio y descriptivo. Incluyó la elaboración y aplicación de un instrumento tipo cuestionario, así como su análisis de tipo descriptivo. Resultados: Se encontró que los docentes: a) están preocupados por el riesgo de que exámenes y tareas sean resueltos con el apoyo de la IAG, b) reconocen los beneficios de la IAG para el análisis de datos, la generación de ideas, la redacción de actividades de aprendizaje y la creación de materiales didácticos, destacando el ahorro de tiempo y la mejora en la calidad educativa, c) están formándose y, en general, se perciben capaces de integrar la IAG en sus clases. Conclusiones: Los docentes se muestran ávidos en el uso de la IAG en lo personal y académico, pero en sus clases sienten preocupación sobre los riesgos, aunque aún no realizan ajustes a sus mecanismos de evaluación.
Creadores de contenido y periodistas en la prensa deportiva española: casos, estrategias y tendencias
Authors: Vaquerizo Domínguez Enrique
Published: August 2024

Introducción: Una de las consecuencias principales que ha traído el ecosistema digital al periodismo deportivo ha sido la confluencia de periodistas profesionales y creadores de contenido, dicha coexistencia está redefiniendo prácticas, contenidos, formatos y formas de dirigirse a las audiencias.  Metodología:  En el presente artículo a través del análisis de casos  hemos detectado, clasificado e investigado diferentes tipologías de creadores de contenido deportivos y estudiado sus dinámicas de producción y promoción a través de casos concretos. Mediante el análisis de contenido y la realización de entrevistas cualitativas hemos determinado los modelos de coexistencia con la prensa digital deportiva en España y el escenario resultante. Resultados: Los resultados han sido concluyentes: la competencia con los creadores de contenido está relegando a los medios deportivos tradicionales a una posición cada vez más segundaria en las nuevas plataformas digitales. Discusión: Esta situación hace replantearse el papel de los medios de comunicación como contenedores de periodistas que articulan sus propias comunidades. Conclusiones: En este contexto los propios periodistas deportivos  encuentran nuevas oportunidades profesionales en su colaboración con los creadores, del mismo modo que algunos emprenden sus proyectos en solitario sin la intermediación de los propios medios.