bluuebunny/crossref_metadata_2025 huggingface dataset:
Time-Varying Price–Volume Relationship and Adaptive Market Efficiency: A Survey of the Empirical Literature
Authors: Patil Ashok , Rastogi Shailesh
Published: June 2019

This paper conducts a review of the literature on the price–volume relationship and its relation with the implications of the adaptive market hypothesis. The literature on market efficiency is classified as efficient market hypothesis (EMH) studies or adaptive market hypothesis (AMH) studies. Under each class, studies are categorized either as return predictability studies or price–volume relationship studies. Finally, review in each category is analyzed based on the methodology used. Our review shows that the literature on return predictability and price–volume relationship in classical EMH approach is extensive while studies in return predictability in the AMH approach have gained increased attention in the last decade. However, the studies in price–volume relationship under adaptive approach are limited, and there is a scope for studies in this area. Authors did not find any literature review on time-varying price–volume relationship. Authors find that there is a scope to study the nonlinear cross–correlation between price and volume using detrended fluctuation analysis (DFA)-detrended cross–correlational analysis (DXA) in the AMH domain. Further, it would be interesting to investigate whether the same cross–correlation holds across different measures of stock indices within a country and across different time scales.
Evaluation of Predation Capability of Periodontopathogens Bacteria by Bdellovibrio Bacteriovorus HD100. An in Vitro Study
Authors: Patini Romeo , Cattani Paola , Marchetti Simona , Isola Gaetano , Quaranta Gianluca , Gallenzi Patrizia
Published: June 2019

Treatment options against periodontitis attempt to completely remove oral microbiota even if several species in dental plaque demonstrate protective features. Predatory bacteria that selectively predate solely on Gram-negative bacteria might be a viable therapeutic alternative. Therefore, the aim of this study is to in vitro evaluate the susceptibility of some oral pathogens to predation by B. bacteriovorus HD100 in liquid suspension. Cultures of prey cell were prepared in brain heart infusion broth (BHI) broth incubating overnight at the appropriate conditions for each organism to reach log phase of growth. Predatory activity was assessed by measuring optical density at 600 nm after 12, 24, 48 and 72 hours. Statistical analysis was performed using the Mann–Whitney U test and p values less than 0.05 were considered statistically significant. The study demonstrated that B. bacteriovorus is able to predate on aerobic species and on microaerophilic ones (p < 0.05) but also that its predatory capacity is strongly compromised by the conditions of anaerobiosis. B. bacteriovorus, in fact, was unable to predate the anaerobic species involved in the present study (F. nucleatum and P. gingivalis). The findings of the study suggest that B. bacteriovorus is able to tolerate microaerophilic conditions and that in anaerobiosis it cannot exert its predatory capacity. Such evidence could lead to its use as an agent to prevent recolonization of the periodontal pocket following therapy. Further studies are needed to investigate the activity of B. bacteriovorus against recently recognized periodontopathogens, alone or organized in biofilms of multi-species communities.
Analysis of Secondary Adhesion Wear Mechanism on Hard Machining of Titanium Aerospace Alloy
Authors: Batista Ponce Moises , Vazquez-Martinez Juan Manuel , Davim Joao Paulo , Salguero Gomez Jorge
Published: June 2019

Titanium alloys are widely used in important manufacturing sectors such as the aerospace industry, internal components of motor or biomechanical components, for the development of functional prostheses. The relationship between mechanical properties and weight and its excellent biocompatibility have positioned this material among the most demanded for specific applications. However, it is necessary to consider the low machinability as a disadvantage in the titanium alloys features. This fact is especially due to the low thermal conductivity, producing significant increases in the temperature of the contact area during the machining process. In this aspect, one of the main objectives of strategic industries is focused on the improvement of the efficiency and the increase of the service life of the elements involved in the machining of this alloy. With the aim to understand the most relevant effects in the machinability of the Ti6Al4V alloy, an analysis is required of different variables of the machining process like tool wear evolution, based on secondary adhesion mechanisms, and the relation between surface roughness of the work-pieces with the cutting parameters. In this research work, a study on the machinability of Ti6Al4V titanium alloy has been performed. For that purpose, in a horizontal turning process, the influence of cutting tool wear effects has been evaluated on the surface finish of the machined element. As a result, parametric behavior models for average roughness (Ra) have been determined as a function of the machining parameters used.
Efficient Adsorption of Lead (II) from Aqueous Phase Solutions Using Polypyrrole-Based Activated Carbon
Authors: Alghamdi Abdulaziz Ali , Al-Odayni Abdel-Basit , Saeed Waseem Sharaf , Al-Kahtani Abdullah , Alharthi Fahad A. , Aouak Taieb
Published: June 2019

In this study, polypyrrole-based activated carbon was prepared by the carbonization of polypyrrole at 650 °C for 2 h in the presence of four-times the mass of KOH as a chemical activator. The structural and morphological properties of the product (polypyrrole-based activated carbon (PPyAC4)), analyzed by scanning electron microscopy, transmission electron microscopy, X-ray diffraction, and thermogravimetric analysis, support its applicability as an adsorbent. The adsorption characteristics of PPyAC4 were examined through the adsorption of lead ions from aqueous solutions. The influence of various factors, including initial ion concentration, pH, contact time, and adsorbent dose, on the adsorption of Pb2+ was investigated to identify the optimum adsorption conditions. The experimental data fit well to the pseudo-second-order kinetic model (R2 = 0.9997) and the Freundlich isotherm equation (R2 = 0.9950), suggesting a chemisorption pathway. The adsorption capacity was found to increase with increases in time and initial concentration, while it decreased with an increase in adsorbent dose. Additionally, the highest adsorption was attained at pH 5.5. The calculated maximum capacity, qm, determined from the Langmuir model was 50 mg/g.
Fatigue Modeling Containing Hardening Particles and Grain Orientation for Aluminum Alloy FSW Joints
Authors: Sun Guoqin , Guo Yicheng , Han Xiuquan , Shang Deguang , Chen Shujun
Published: June 2019

The macro-mesoscopic joint fatigue model containing hardening particles and crystal characteristics is established to study the effect of the hardening particles and the grain orientation on fatigue properties of an aluminum alloy friction stir welding (FSW) joint. The macroscopic model is composed of the weld nugget zone, thermo-mechanically affected zone, heat-affected zone, and base material, according to the metallurgical morphology and hardness distribution of the joint. Cyclic stress and strain data are used to determine the material properties. The fatigue parameters used in the calculation of cyclic stresses and strains are obtained with the four-point correlation method. The mesoscopic models of different zones are inserted into the joint macroscopic model as submodules. The models containing the information of hardening particles and grain orientation are established with crystal plasticity theory for the grains and isotropic hardening rule for the hardening particles. The effects of hardening particles and grain orientation on the stress and strain responses are discussed. The simulation results show that high-angle misorientation of adjacent grains hinders the stress transfer. The particle cluster or cracked particles intensify the stress and strain concentrations.
VOC Emissions from Spruce Strands and Hemp Shive: In Search for a Low Emission Raw Material for Bio-Based Construction Materials
Authors: Adamová Tereza , Hradecký Jaromír , Prajer Marek
Published: June 2019

Volatile organic compounds (VOCs) reduce indoor air quality. They are associated with negative effects on human health and wellbeing. In terms of legislation requirements and consumer pressure, VOCs from engineered wood materials are reduced due to use of water based additives and adhesives in their formulation. Therefore, the main source of VOCs remains the raw material—the wood itself. Alternatives to wood strands, annual plant materials, are tested nowadays due to their advantages: The short cycle; the raw material is sourced naturally and can be produced more sustainably; and faster sequestering atmospheric carbon. The aim of this work was to investigate volatile organic compounds emitted from untreated and chemically treated hemp shive and compare the emission characteristics to soft wood strands. Simple, yet effective chemical treatments, like tartaric acid, citric acid and sodium bicarbonate were used in order to reduce VOC emissions. Gas chromatography-mass spectrometry (GC-MS) combined with headspace solid-phase microextraction (HS-SPME) was used to analyse the volatile compounds emissions. Specific VOCs like acetic acid; Benzaldehyde; hexanal, α-, β-pinenes; limonene and camphene were monitored before and after the treatments. Non-target screening was performed to identify the most responsible compound for differentiation of samples according to their treatments. Comparing untreated samples, spruce strands showed highest amounts of total VOCs, while untreated hemp shive showed the lowest. Further, due to the chemical modification of hemp woody core components, such as hemicelluloses, lignin, and extractives, the key VOCs showed significant changes leading to an increase in the amount of total emissions.
Correction: Ali, M., et al. Study on the Development of Neutrosophic Triplet Ring and Neutrosophic Triplet Field. Mathematics 2018, 6, 46
Authors: Çeven Yılmaz , Smarandache Florentin
Published: June 2019

We have found the following errors in the article which was recently published in Mathematics [...]
In Silico Insights into HIV-1 Vpu-Tetherin Interactions and Its Mutational Counterparts
Authors: Sneha Patil , Shah Urmi , Balaji Seetharaman
Published: June 2019

Tetherin, an interferon-induced host protein encoded by the bone marrow stromal antigen 2 (BST2/CD317/HM1.24) gene, is involved in obstructing the release of many retroviruses and other enveloped viruses by cross-linking the budding virus particles to the cell surface. This activity is antagonized in the case of human immunodeficiency virus (HIV)-1 wherein its accessory protein Viral Protein U (Vpu) interacts with tetherin, causing its downregulation from the cell surface. Vpu and tetherin connect through their transmembrane (TM) domains, culminating into events leading to tetherin degradation by recruitment of β-TrCP2. However, mutations in the TM domains of both proteins are reported to act as a resistance mechanism to Vpu countermeasure impacting tetherin’s sensitivity towards Vpu but retaining its antiviral activity. Our study illustrates the binding aspects of blood-derived, brain-derived, and consensus HIV-1 Vpu with tetherin through protein–protein docking. The analysis of the bound complexes confirms the blood-derived Vpu–tetherin complex to have the best binding affinity as compared to other two. The mutations in tetherin and Vpu are devised computationally and are subjected to protein–protein interactions. The complexes are tested for their binding affinities, residue connections, hydrophobic forces, and, finally, the effect of mutation on their interactions. The single point mutations in tetherin at positions L23Y, L24T, and P40T, and triple mutations at {L22S, F44Y, L37I} and {L23T, L37T, T45I}, while single point mutations in Vpu at positions A19H and W23Y and triplet of mutations at {V10K, A11L, A19T}, {V14T, I18T, I26S}, and {A11T, V14L, A15T} have revealed no polar contacts with minimal hydrophobic interactions between Vpu and tetherin, resulting in reduced binding affinity. Additionally, we have explored the aggregation potential of tetherin and its association with the brain-derived Vpu protein. This work is a possible step toward an understanding of Vpu–tetherin interactions.
Tensile Properties and Corrosion Resistance of Al-xFe-La Alloys for Aluminium Current Collector of Lithium-Ion Batteries
Authors: Yang Xin , Ding Dongyan , Xu Yawu , Zhang Wenlong , Gao Yongjin , Wu Zhanlin , Chen Guozhen , Chen Renzong , Huang Yuanwei , Tang Jinsong
Published: June 2019

Al-xFe-La alloys (x = 0.07, 0.1, 0.2) for aluminum current collectors of lithium-ion batteries were prepared and the microstructure of Al-0.07Fe-0.07La, Al-0.1Fe-0.07La and Al-0.2Fe-0.07La aluminum alloys were observed by scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS). The experimental results showed that with the increase of Fe content, the size of the second phases in Al-xFe-0.07La alloys became finer and more dispersed and that the microstructure of the alloy had improved. The strength and corrosion resistance of Al-xFe-La alloys were studied by tensile tests and electrochemical tests and the morphological investigations of samples were also conducted by SEM and EDS. With the increase of Fe content, the strength and corrosion resistance of Al-xFe-La alloys became better. Compared to Al-0.07Fe-0.07La alloy, the yield strength and tensile strength of the Al-0.2Fe-0.07La alloy increased by 51.19% and 58.48% respectively, and the elongation increased by 88.41%. Moreover, Al-0.2Fe-0.07La alloy had much more positive corrosion potential and much smaller corrosion current than those of Al-0.07Fe-0.07La alloy.
Determination of Grain Growth Kinetics and Assessment of Welding Effect on Properties of S700MC Steel in the HAZ of Welded Joints
Authors: Moravec Jaromir , Novakova Iva , Sobotka Jiri , Neumann Heinz
Published: June 2019

The welding of fine-grained steels is a very specific technology because of the requirement for the heat input limit value. Applying temperature cycles results in an intense grain growth in a high-temperature heat-affected zone (HAZ). This has a significant effect on the changing of strength properties and impact values. The intensity of grain coarsening in the HAZ can be predicted based on the experimentally determined activation energy and material constant, both of which define grain growth kinetics. These quantities, together with real measured welding cycles, can be subsequently used during experiments to determine mechanical properties in a high-temperature HAZ. This paper shows a methodical procedure leading to the obtainment of the material quantities mentioned above that define the grain growth, both at fast and slow temperature cycles. These data were used to define the exposure temperature and the soaking time in a vacuum furnace to prepare test samples with grain sizes corresponding to the high-temperature HAZ of welded joints for the testing procedures. Simultaneously, by means of the thermo-mechanical simulator Gleeble 3500, testing samples were prepared which, due to a temperature gradient, created conditions comparable to those in the HAZ. The experiments were both carried out with the possibility of free sample dilatation and under a condition of zero dilation, which happens when the thermal expansion of a material is compensated by plastic deformation. It has been found that shape of the temperature cycle, maximal achieved cycle temperature, cooling rate, and, particularly, the time in which the sample is in the austenite region have significant effects on the resulting change of properties.
Research on the Protrusions Near Silicon-Glass Interface during Cavity Fabrication
Authors: Zhang Meng , Yang Jian , He Yurong , Yang Fan , Zhao Yongmei , Xue Fen , Han Guowei , Si Chaowei , Ning Jin
Published: June 2019

Taking advantage of good hermeticity, tiny parasitic capacitance, batch mode fabrication, and compatibility with multiple bonding techniques, the glass-silicon composite substrate manufactured by the glass reflow process has great potential to achieve 3D wafer-level packaging for high performance. However, the difference in etching characteristics between silicon and glass inevitably leads to the formation of the undesired micro-protrusions near the silicon-glass interface when preparing a shallow cavity etched around a few microns in the composite substrate. The micro-protrusions have a comparable height with the depth of the cavity, which increases the risks of damages to sensitive structures and may even trigger electrical breakdown, resulting in thorough device failure. In this paper, we studied the characteristics of the chemical composition and etching mechanisms at the interface carefully and proposed the corresponding optimized solutions that utilized plasma accumulation at the interface to accelerate etching and bridge the gap in etching rates between different chemical compositions. Finally, a smooth transition of 131.1 nm was achieved at the interface, obtaining an ideal etching cavity surface and experimentally demonstrating the feasibility of our proposal. The micromachining solution is beneficial for improving the yield and structural design flexibility of higher performance micro-electromechanical systems (MEMS) devices.
A Shear-Mode Piezoelectric Heterostructure for Electric Current Sensing in Electric Power Grids
Authors: He Wei , Yang Aichao
Published: June 2019

This paper presents a shear-mode piezoelectric current sensing device for two-wire power cords in electric power grids. The piezoelectric heterostructure consists of a cymbal structure and a permalloy plate. The cymbal structure is constructed from a permanent magnet, a brass cap, and shear-mode piezoelectric materials. The permalloy plate concentrates the magnetic field generated by the two-wire power cord on the magnet. Under the force amplification effect of the cymbal structure, the response of the device is improved. A prototype has been fabricated to conduct the experiments. The experimental average sensitivity of the device is 12.74 mV/A in the current range of 1–10 A with a separating distance of d = 0 mm, and the resolution reaches 0.04 A. The accuracy is calculated to be ±0.0177 mV at 1.5 A according to the experimental voltage distribution. The current-to-voltage results demonstrate that the proposed heterostructure can also be used as a magnetoelectric device without bias.
Research Progress of Near-Infrared Fluorescence Immunoassay
Authors: Chang Xiao-Hui , Zhang Jie , Wu Lin-Huan , Peng Yan-Kun , Yang Xiang-Ying , Li Xiao-Lin , Ma Ai-Jin , Ma Jun-Cai , Chen Guang-Quan
Published: June 2019

Near-infrared fluorescence probes (NIFPs) have been widely used in immunoassay, bio-imaging and medical diagnosis. We review the basic principles of near-infrared fluorescence and near-infrared detection technology, and summarize structures, properties and characteristics of NIFPs (i.e., cyanines, xanthenes fluorescent dyes, phthalocyanines, porphyrin derivates, single-walled carbon nanotubes (SWCNTs), quantum dots and rare earth compounds). We next analyze applications of NIFPs in immunoassays, and prospect the application potential of lateral flow assay (LFA) in rapid detection of pathogens. At present, our team intends to establish a new platform that has highly sensitive NIFPs combined with portable and simple immunochromatographic test strips (ICTSs) for rapid detection of food-borne viruses. This will provide technical support for rapid detection on the port.
Epstein–Barr Virus and Innate Immunity: Friends or Foes?
Authors: Jangra Sonia , Yuen Kit-San , Botelho Michael George , Jin Dong-Yan
Published: June 2019

Epstein–Barr virus (EBV) successfully persists in the vast majority of adults but causes lymphoid and epithelial malignancies in a small fraction of latently infected individuals. Innate immunity is the first-line antiviral defense, which EBV has to evade in favor of its own replication and infection. EBV uses multiple strategies to perturb innate immune signaling pathways activated by Toll-like, RIG-I-like, NOD-like, and AIM2-like receptors as well as cyclic GMP-AMP synthase. EBV also counteracts interferon production and signaling, including TBK1-IRF3 and JAK-STAT pathways. However, activation of innate immunity also triggers pro-inflammatory response and proteolytic cleavage of caspases, both of which exhibit proviral activity under some circumstances. Pathogenic inflammation also contributes to EBV oncogenesis. EBV activates NFκB signaling and induces pro-inflammatory cytokines. Through differential modulation of the proviral and antiviral roles of caspases and other host factors at different stages of infection, EBV usurps cellular programs for death and inflammation to its own benefits. The outcome of EBV infection is governed by a delicate interplay between innate immunity and EBV. A better understanding of this interplay will instruct prevention and intervention of EBV-associated cancers.
Pilot-Scale Removal of Arsenic and Heavy Metals from Mining Wastewater Using Adsorption Combined with Constructed Wetland
Authors: Nguyen Ha , Nguyen Bien , Duong Thuy , Bui Anh , Nguyen Hang , Cao Ha , Mai Nhuan , Nguyen Khai , Pham Thuy , Kim Kyoung-Woong
Published: June 2019

This study was conducted to assess the removal of arsenic (As) and heavy metals from mining wastewater by the combination of adsorption, using modified iron-ore drainage sludge, and horizontal-subsurface-flow constructed wetland with common reed (Phragmites australis). The pilot-scale experiment with a constant flow rate of 5 m3/day was operated for four months using real wastewater from a Pb–Zn mine in northern Vietnam. Atomic absorption spectroscopy was used for elemental analysis in wastewater and plant. X-ray diffraction (XRD), surface charge measurements (by a particle charge detector (PCD)), Fourier-transform infrared (FTIR), and surface area Brunauer–Emmet–Teller (BET) measurements were performed to determine the characteristics of the adsorbent. The results showed that the average removals of As, Mn, Cd, Zn, and Pb by the combined system with limestone substrate during four months were 80.3%, 96.9%, 79.6%, 52.9%, and 38.7%, respectively. The use of another constructed wetland substrate, laterite, demonstrated better removal efficiency of As than limestone. The concentrations of As and heavy metals in the effluent were lower than the limits established by the QCVN 40:2011/BTNMT for industrial wastewater, which indicated the feasibility of combining adsorption and constructed wetland for the treatment of mining wastewater.
Biotic–Abiotic Influences on Modern Ca–Si-Rich Hydrothermal Spring Mounds of the Pastos Grandes Volcanic Caldera (Bolivia)
Authors: Bougeault Cédric , Vennin Emmanuelle , Durlet Christophe , Muller Elodie , Mercuzot Mathilde , Chavez Marco , Gérard Emmanuelle , Ader Magali , Virgone Aurélien , Gaucher Eric C.
Published: June 2019

The lacustrine-to-palustrine Pastos Grandes Laguna (Bolivia) is located in a volcanic caldera fed by active hot springs, with a carbonate crust extending over 40 km2. An integrated approach based on geology and hydrochemistry was used to characterize La Salsa, one of its hydrothermal systems, composed of a flat mound with a hydrothermal discharge. The mound is composed of carbonate–diatom aggregates, forming muds that accumulate and undergo slight swelling. The discharge area along the hydrothermal pathway exhibits several facies and microfabrics, with considerable biological activity and microbialite development. Both the downstream evolution of carbonate and silica content in sediments and the distribution of microbialites can be linked to changes in biotic-abiotic processes occurring along the pathway. The spatial distribution of microbialites and their morphologies are related to hydrodynamic conditions, the nature of the substrate on which they grow and, to a lesser extent, to the accommodation space available. The evolution of the physicochemical properties of the water and biological activity mainly impact mineral precipitation but also affect microbialite morphologies and microstructures. This atypical Si- and Ca-rich hydrothermal system therefore provides insights into the diversity of environmental, chemical, and biotic factors controlling mineralization, which also responds to independent thermodynamic controls.
Geochemistry of Magmatic and Xenocrystic Spinel in the No.30 Kimberlite Pipe (Liaoning Province, North China Craton): Constraints on Diamond Potential
Authors: Zhu Ren-Zhi , Ni Pei , Ding Jun-Ying , Wang Guo-Guang
Published: June 2019

There are two genetic types of spinel (magmatic spinel crystallizing directly from kimberlite magma and xenocrystic spinel derived from mantle xenoliths) in the No.30 kimberlite pipe (Liaoning Province, North China Craton). Their geochemistry is investigated to reveal processes of diamond capture and resorption during kimberlite magmatism to constrain the diamond potential. Magmatic spinels are mostly euhedral to subhedral, 20 to 60 µm in size, and have compositional zones: the cores are classified as chromite with high Cr and Mg contents, and the rims are classified as magnetite with low Cr and high ferric Fe. The compositional trends suggest that magmatic spinel and olivine phenocrysts are crystallized contemporaneously during the early stages of kimberlite crystallization. During this period, temperature (T) and oxygen fugacity (fO2) values calculated at an assumed pressure of 1 GPa are in the range of 994–1274 °C and 1.6–2.4 log fO2 units below the nickel-nickel oxide (NNO) buffer, respectively. The high values of fO2 suggest heavy diamond resorption during kimberlite magmatism. Estimated temperatures of xenocrystic spinel range from 828 to 1394 °C, and their distributions indicate that only a small proportion of xenocrystic spinels are derived from the diamond stabilization field, which suggests a low potential of diamond capture. The low diamond capture and heavy diamond resorption during kimberlite magmatism contributed to the low diamond grade of the No.30 kimberlite.
A Simple and Efficient Mechanochemical Route for the Synthesis of Salophen Ligands and of the Corresponding Zn, Ni, and Pd Complexes
Authors: Leoni Luca , Carletta Andrea , Fusaro Luca , Dubois Jean , Tumanov Nikolay A. , Aprile Carmela , Wouters Johan , Dalla Cort Antonella
Published: June 2019

A number of salophen ligands and their Zn, Ni, and Pd complexes were synthesized by an efficient one-pot mechanosynthesis protocol. The reaction products were characterized by means of complementary solid-state techniques, i.e., powder X-ray diffraction, single-crystal X-ray diffraction, and solid-state NMR spectroscopy. Four new crystal structures of metal salophen complexes as DMSO solvates are here reported. The described simple and relatively fast (about 1 h for all derivatives) procedure is a good alternative to classical methods performed in organic solvents.
Copper Nanowires Modified with Graphene Oxide Nanosheets for Simultaneous Voltammetric Determination of Ascorbic Acid, Dopamine and Acetaminophen
Authors: Hao Wanting , Zhang Yuchan , Fan Jingchuan , Liu Handeng , Shi Qi , Liu Weichi , Peng Qianyu , Zang Guangchao
Published: June 2019

Copper nanowires (Cu NWs) were modified with graphene oxide (GO) nanosheets to obtain a sensor for simultaneous voltammetric determination of ascorbic acid (AA), dopamine (DA) and acetaminophen (AC). The nanocomposite was obtained via sonication, and its structures were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD) and energy-dispersive X-ray spectroscopy (EDS). The electrochemical oxidation activity of the materials (placed on a glassy carbon electrode) was studied by cyclic voltammetry and differential pulse voltammetry. Due to the synergistic effect of Cu NWs and GO, the specific surface, electrochemical oxidation performance and conductivity are improved when compared to each individual component. The peaks for AA (−0.08 V), DA (+0.16 V), and AC (+0.38 V) are well separated. The sensor has wide linear ranges which are from 1–60 μM, 1–100 μM, and 1–100 μM for AA, DA, and AC, respectively, when operated in the differential pulse voltammetric mode. The detection limits are 50, 410 and 40 nM, respectively. Potential interferences by uric acid (20 μM), glucose (10 mM), NaCl (1 mM), and KCl (1 mM) were tested for AA (1 μΜ), DA (1 μΜ), and AC (1 μΜ) and were found to be insignificant. The method was successfully applied to the quantification of AA, DA, and AC in spiked serum samples.
Ethanol Extract of Illicium henryi Attenuates LPS-Induced Acute Kidney Injury in Mice via Regulating Inflammation and Oxidative Stress
Authors: Islam Md Sodrul , Miao Lingyan , Yu Hui , Han Ziyi , Sun Hongxiang
Published: June 2019

The root bark of Illicium henryi has been used in traditional Chinese medicine to treat various diseases. Its ethanol extract (EEIH) was found to contain a large number of phenols and possess in vitro antioxidant activities. The present study aimed to investigate its protective effect against lipopolysaccharide (LPS)-induced acute kidney injury (AKI) in mice. BALB/c mice were intraperitoneally pretreated with EEIH for five days, and then LPS injection was applied to induce AKI. Blood samples and kidney tissues were collected and used for histopathology, biochemical assay, enzyme-linked immunosorbent assay (ELISA), quantitative real-time polymerase chain reaction (qRT-PCR), and Western blot analyses. EEIH not only significantly dose-dependently attenuated histological damage and reduced renal myeloperoxidase (MPO) activity (from 9.77 ± 0.73 to 0.84 ± 0.30 U/g tissue) but also decreased serum creatinine (from 55.60 ± 2.70 to 27.20 ± 2.39 µmol/L) and blood urea nitrogen (BUN) (from 29.95 ± 1.96 to 16.12 ± 1.24 mmol/L) levels in LPS-treated mice. EEIH also markedly dose-dependently inhibited mRNA expression and production of TNF-α (from 140.40 ± 5.15 to 84.74 ± 5.65 pg/mg), IL-1β (from 135.54 ± 8.20 to 77.15 ± 5.34 pg/mg), IL-6 (from 168.74 ± 7.23 to 119.16 ± 9.35 pg/mg), and COX-2 in renal tissue of LPS-treated mice via downregulating mRNA and protein expressions of toll-like receptor 4 (TLR4) and phosphorylation of nuclear factor-κB (NF-κB) p65. Moreover, EEIH significantly dose-dependently reduced malondialdehyde (MDA) (from 5.43 ± 0.43 to 2.80 ± 0.25 nmol/mg prot) and NO (from 1.01 ± 0.05 to 0.24 ± 0.05 µmol/g prot) levels and increased superoxide dismutase (SOD) (from 22.32 ± 2.92 to 47.59 ± 3.79 U/mg prot) and glutathione (GSH) (from 6.57 ± 0.53 to 16.89 ± 0.68 µmol/g prot) levels in renal tissue induced by LPS through upregulating mRNA expression of nuclear factor erythroid 2 related factor 2 (Nrf2). Furthermore, EEIH inhibited LPS-induced intracellular reactive oxygen species (ROS) production from RAW264.7 cells in a concentration-dependent manner. These results suggest that EEIH has protective effects against AKI in mice through regulating inflammation and oxidative stress.
Identifying Dietary Strategies to Improve Nutrient Adequacy among Ethiopian Infants and Young Children Using Linear Modelling
Authors: Samuel Aregash , Osendarp Saskia J. M. , Ferguson Elaine , Borgonjen Karin , Alvarado Brenda M. , Neufeld Lynnette M. , Adish Abdulaziz , Kebede Amha , Brouwer Inge D.
Published: June 2019

Nutrient adequacy of young children’s diet and best possible strategies to improve nutrient adequacy were assessed. Data from the Ethiopian National Food Consumption Survey were analysed using Optifood (software for linear programming) to identify nutrient gaps in diets for children (6–8, 9–11 and 12–23 months), and to formulate feasible Food-Based Dietary Recommendations (FBDRs) in four regions which differ in culture and food practices. Alternative interventions including a local complementary food, micronutrient powders (MNPs), Small quantity Lipid-based Nutrient Supplement (Sq-LNS) and combinations of these were modelled in combination with the formulated FBDRs to compare their relative contributions. Risk of inadequate and excess nutrient intakes was simulated using the Estimated Average Requirement cut-point method and the full probability approach. Optimized local diets did not provide adequate zinc in all regions and age groups, iron for infants <12 months of age in all regions, and calcium, niacin, thiamine, folate, vitamin B12 and B6 in some regions and age-groups. The set of regional FBDRs, considerably different for four regions, increased nutrient adequacy but some nutrients remained sub-optimal. Combination of regional FBDRs with daily MNP supplementation for 6–12 months of age and every other day for 12–23 months of age, closed the identified nutrient gaps without leading to a substantial increase in the risk of excess intakes.
Pathways from Food Insecurity to Health Outcomes among California University Students
Authors: Martinez Suzanna M. , Grandner Michael A. , Nazmi Aydin , Canedo Elias Ruben , Ritchie Lorrene D.
Published: June 2019

The prevalence of food insecurity (FI) among college students is alarmingly high, yet the impact on student health has not been well investigated. The aim of the current study was to examine the simultaneous relationships between food insecurity and health-related outcomes including body mass index (BMI) and overall health in a college student population. Randomly sampled students in the University of California 10 campus system were invited to participate in an online survey in spring 2015. The analytic sample size was 8705 graduate and undergraduate students. Data were collected on FI in the past year, daily servings of fruits and vegetables (FV), number of days in the past week of enough sleep and moderate- to vigorous-intensity physical activity (MVPA), height and weight, self-rated health, and student characteristics. Using path analysis, mediated pathways between FI, BMI, and poor health were examined through FV intake, number of days of MVPA and enough sleep. Analyses controlled for student characteristics. Mean BMI was 23.6 kg/m2 (SD, 5.0), and average self-rated health was good. FI was directly and indirectly related to higher BMI and poor health through three pathways. First, FI was related to fewer days of enough sleep, which in turn was related to increased BMI and poor health. Second, FI was related to fewer days of MVPA, which in turn was related to increased BMI and poor health. Third, FI was related to fewer daily servings of FV, which in turn was related to poor health. FI is associated with poor health behaviors among college students, which may contribute to higher weight status and poor health. These findings highlight the importance of food security for a healthy college experience.
Dietary Support in Elderly Patients with Inflammatory Bowel Disease
Authors: Eder Piotr , Niezgódka Alina , Krela-Kaźmierczak Iwona , Stawczyk-Eder Kamila , Banasik Estera , Dobrowolska Agnieszka
Published: June 2019

Ageing of the human population has become a big challenge for health care systems worldwide. On the other hand, the number of elderly patients with inflammatory bowel disease (IBD) is also increasing. Considering the unique clinical characteristics of this subpopulation, including many comorbidities and polypharmacy, the current therapeutic guidelines for the management of IBD should be individualized and applied with caution. This is why the role of non-pharmacological treatments is of special significance. Since both IBD and older age are independent risk factors of nutritional deficiencies, appropriate dietary support should be an important part of the therapeutic approach. In this review paper we discuss the interrelations between IBD, older age, and malnutrition. We also present the current knowledge on the utility of different diets in the management of IBD. Considering the limited data on how to support IBD therapy by nutritional intervention, we focus on the Mediterranean and Dietary Approaches to Stop Hypertension diets, which seem to be the most beneficial in this patient group. We also discuss some new findings on their hypothetical anti-inflammatory influence on the course of IBD.
Psychotropic Drugs for the Management of Chronic Pain and Itch
Authors: Belinskaia Daria A. , Belinskaia Mariia A. , Barygin Oleg I. , Vanchakova Nina P. , Shestakova Natalia N.
Published: June 2019

Clinical observations have shown that patients with chronic neuropathic pain or itch exhibit symptoms of increased anxiety, depression and cognitive impairment. Such patients need corrective therapy with antidepressants, antipsychotics or anticonvulsants. It is known that some psychotropic drugs are also effective for the treatment of neuropathic pain and pruritus syndromes due to interaction with the secondary molecular targets. Our own clinical studies have identified antipruritic and/or analgesic efficacy of the following compounds: tianeptine (atypical tricyclic antidepressant), citalopram (selective serotonin reuptake inhibitor), mianserin (tetracyclic antidepressant), carbamazepine (anticonvulsant), trazodone (serotonin antagonist and reuptake inhibitor), and chlorprothixene (antipsychotic). Venlafaxine (serotonin-norepinephrine reuptake inhibitor) is known to have an analgesic effect too. The mechanism of such effect of these drugs is not fully understood. Herein we review and correlate the literature data on analgesic/antipruritic activity with pharmacological profile of these compounds.
On-Chip Guiding of Higher-Order Orbital Angular Momentum Modes
Authors: Lee In Joon , Kim Sangin
Published: June 2019

Higher-order orbital angular momentum (OAM) mode guiding in a waveguide which is suitable for on-chip integration has been investigated. Based on the relation between the Laguerre-Gaussian mode and the Hermite-Gaussian mode, it has been shown that two degenerate guided modes of π/2l-rotation symmetry can support the l-th order OAM mode. In order to mimic the rotational symmetry, we have proposed the waveguide structure of a cross-shaped core and designed a waveguide that can support OAM modes of ±1 and ±2 topological charges simultaneously at a wavelength of 1550 nm. Purity of the OAM modes guided in the designed waveguide has been assessed by numerically calculating their topological charges from the field distribution, which were close to the theoretical values. We also investigated the guiding of OAM modes of ±3 and ±4 topological charges in our proposed waveguide structure, which revealed the possibility of the separate guiding of those OAM modes with relatively lower purity.
A Proteomic View of Cellular Responses to Anticancer Quinoline-Copper Complexes
Authors: Dalzon Bastien , Bons Joanna , Diemer Hélène , Collin-Faure Véronique , Marie-Desvergne Caroline , Dubosson Muriel , Cianferani Sarah , Carapito Christine , Rabilloud Thierry
Published: June 2019

Metal-containing drugs have long been used in anticancer therapies. The mechansims of action of platinum-based drugs are now well-understood, which cannot be said of drugs containing other metals, such as gold or copper. To gain further insights into such mechanisms, we used a classical proteomic approach based on two-dimensional elelctrophoresis to investigate the mechanisms of action of a hydroxyquinoline-copper complex, which shows promising anticancer activities, using the leukemic cell line RAW264.7 as the biological target. Pathway analysis of the modulated proteins highlighted changes in the ubiquitin/proteasome pathway, the mitochondrion, the cell adhesion-cytoskeleton pathway, and carbon metabolism or oxido-reduction. In line with these prteomic-derived hypotheses, targeted validation experiments showed that the hydroxyquinoline-copper complex induces a massive reduction in free glutathione and a strong alteration in the actin cytoskeleton, suggesting a multi-target action of the hydroxyquinoline-copper complex on cancer cells.
Form and Content in Buber’s and Schweid’s Literary-Philosophical Readings of Genesis
Authors: Cohen Jonathan
Published: June 2019

The following essay is presented as part of a long-term project concerned with the theory and practice of modern Jewish thinkers as interpreters of the Bible. The recent Bible commentaries of Eliezer Schweid, who is one of the foremost Jewish scholars and theologians active in Israel today, are analyzed in comparison with parallel interpretations of Martin Buber, with special reference to the first chapters of Genesis. Their respective analyses of Biblical narrative reveal notable similarities in their treatment of the literary “body” of the text as the key to its theological significance. Nonetheless, Buber articulates religious experience largely “from the human side,” striving to mediate Biblical consciousness to the contemporary humanistic mindset, while Schweid positions himself more as the clarion of the “prophetic writers” for whom the fear of God, no less than the love of God, must inform an authentic religious sensibility. Schweid’s more theocentric perspective has great import for contemporary issues such as the universal covetousness engendered by the violation of our ecological covenant with the Earth.
Why Study Religion from a Latin American Sociological Perspective? An Introduction to Religions Issue, “Religion in Latin America, and among Latinos Abroad”
Authors: Morello Gustavo
Published: June 2019

This article introduces the Religions issue on Latin American religiosity exploring sociological perspectives on the Latin American religious situation, from a Latin American perspective. The Secularization Theory proposes “the more modernity, the less religion”, but in Latin America we see both, modernity and religiosity. The Religious Economy model, on the other hand, affirms “the more pluralization, the more religion”, but in Latin America there is not so much pluralization, and it is not easy to switch from one religion to other. Finally, the article presents a Latin American model, the “popular religiosity” one. The problem with it, is that it is mostly ‘Catholic,’ and so does not account for the growing religious diversity in the region. It also emphasizes the “popular” aspect, excluding middle socioeconomic status individuals and elites, assuming they practice “real” religion. This introduction presents a critical approach as a way to recover, describe, and understand Latin American religious practices. This methodology might be a path to creating sociological categories to understand religion beyond the north Atlantic world.
A Study of the Technology Used to Distinguish Sea Ice and Seawater on the Haiyang-2A/B (HY-2A/B) Altimeter Data
Authors: Jiang Chengfei , Lin Mingsen , Wei Hao
Published: June 2019

When the Haiyang-2B (HY-2B) was launched into space to form a star network with the Haiyang-2A (HY-2A), it provided new data sources for the sea ice research of the Earth’s polar regions. The ability of altimeter echoes to distinguish sea ice and sea water is usable in operational ice charting. In this research study, the level 1B (L1B) data of HY-2A/B altimeter from November 2018 was used to analyze the altimeter waveforms from the polar regions. The Suboptimal Maximum Likelihood Estimation (SMLE) and Offset Center of Gravity (OCOG) tracking packages could maintain the waveform characteristics of diffused and quasi-specular surfaces by comparison. Also, they could be utilized to distinguish sea ice from seawater in the polar regions. It was determined that the types of echoes obtained from the seawater were diffuse. Also, some “ocean-like” waveform data had existed for the old ice formations in the Arctic regions during the study period. The types of echoes obtained from Arctic sea ice were found to be mainly quasi-specular. In the present study, three methods (Threshold segmentation, K-nearest-neighbor (KNN), and Lib-Support Vector machine (LIBSVM)) with four waveform parameters (Automatic Gain Control (AGC) and Pulse Peaking (PP) values of the Ku and C Bands) were adopted to distinguish between the sea ice and seawater areas. The accuracy rate of the separation results for the LIBSVM except band Ku from HY-2B ALT was found to be less than 40% in Antarctic. Meanwhile, the other two methods were observed to have maintained the waveforms correctly at accuracy rates of approximately 80% in Antarctic and the Arctic. In addition, the observed distinguishing errors were located in the regions of the old ice of the Arctic region. In addition, due to the summer melting processes, the large number of ice floes and the snow cover had made it difficult to distinguish the seawater and sea ice in the Antarctic regions.
Transfer and Association: A Novel Detection Method for Targets without Prior Homogeneous Samples
Authors: Zhou Guangjiao , Zhang Ye
Published: June 2019

A primary problem faced during previous research was the gap in limited and unbalanced quantity of prior samples between computer classification tasks and targeted remote sensing applications. This paper presents the fusion method to overcome this limitation. It offers a novel method based on knowledge transfer and feature association, a strong combination of transfer learning and data fusion. The former reuses layers trained on complete data sets to compute a mid-level representation of the specific target. The latter brings additional information from heterogeneous sources to enrich the features in the target domain. Firstly, a basic convolutional neural network (B_CNN) is pretrained on to the CIFAR-10 dataset to produce a stable model responsible for general feature extraction from multiple inputs. Secondly, a transfer CNN (Trans_CNN) with fine-tuned and transferred parameters is constraint-trained to fit and switch between differing tasks. Meanwhile, the feature association (FA) frames a new feature space to achieve integration between training and testing samples from different sensors. Finally, on-line detection can be completed based on Trans_CNN to explore a state-of-the-art method to overcome the inadequate sample problems in real remote sensing applications rather than produce an unrolled version of training methods or structural improvement in CNN. Experimental results show that target detection rates without homogeneous prior samples can reach 85%. Under these conditions, the traditional CNN model is invalid.