bluuebunny/crossref_metadata_2025 huggingface dataset:
La experiencia del espectador-usuario como factor primordial para la adecuación del modelo expositivo de un proyecto de arte relacionado con el genocidio, basado en fotografías socio-documentales = The viewer-user experience as a fundamental factor for the adaptation of the exhibition model of an art project related to genocide, based on socio-documentary photographs
Authors: Gómez Ballesteros Eduardo , Barban Franceschi Roberta
Published: January 2020

El presente artículo tiene como objetivo realizar una reflexión sobre la importancia de la experiencia de usuario en las obras de arte basadas en fotografía socio-documental, referido en concreto al proyecto artístico GENOCIDE PROJECT. Se trata de verificar cómo el factor memoria del usuario es importante a la hora de exponer la obra al público. La experiencia del espectador-usuario se fundamenta en tres elementos: arte, usuario y contexto. La configuración de estos elementos define las dos experiencias relatadas, en las que el espectador-usuario se convierte en el componente decisivo en el diseño y elaboración del modelo expositivo.AbstractThis article aims to reflect on the importance of user experience in artistic works based on socio-documentary photography, specifically referring to the artistic project GENOCIDE PROJECT. It is about verifying how the user's memory factor is important when exposing the work to the public. The experience of the viewer-user is based on three elements: art, user and context. The configuration of these elements will define the two experiences reported, in which the viewer-user becomes the decisive component in the design and development of the exhibition model.
Multivariate characterisation of Italian monovarietal red wines using MIR spectroscopy
Authors: Parpinello Giuseppina P. , Ricci Arianna , Arapitsas Panagiotis , Curioni Andrea , Moio Luigi , Riosegade Susanna , Ugliano Maurizio , VERSARI Andrea
Published: January 2020

Aim: The aim of this study was to investigate the application of mid-infrared (MIR) spectroscopy combined with multivariate analysis, to provide a rapid screening tool for discriminating among different Italian monovarietal red wines based on the relationship between grape variety and wine composition in particular phenolic compounds.Methods and results: The MIR spectra (from 4000 to 700 cm‒1) of 110 monovarietal Italian red wines, vintage 2016, were collected and evaluated by selected multivariate data analyses, including principal component analysis (PCA), linear discriminant analysis (DA), support vector machine (SVM), and soft intelligent modelling of class analogy (SIMCA). Samples were collected directly from companies across different regions of Italy and included 11 grape varieties: Sangiovese, Nebbiolo, Aglianico, Nerello Mascalese, Primitivo, Raboso, Cannonau, Teroldego, Sagrantino, Montepulciano and Corvina.
PCA showed five wavelengths that mainly contributed to the PC1, including a much-closed peak at 1043 cm‒1, which correspond to the C–O stretch absorption bands that are important regions for glycerol, whereas the ethanol peaks at around 1085 cm‒1. The band at 877 cm‒1 are related to the C–C stretching vibration of organic molecules, whereas the asymmetric stretching for C–O in the aromatic –OH group of polyphenols is within spectral regions from 1050 to 1165 cm‒1. In particular, the (1175)–1100–1060 cm‒1 vibrational bands are combination bands, involving C–O stretching and O–H deformation of phenolic rings. The 1166–1168 cm‒1 peak is attributable to in-plane bending deformations of C–H and C–O groups of polyphenols, respectively, for which polymerisation may cause a slight peak shift due to the formation of H-bridges.The best result was obtained with the SVM, which achieved an overall correct classification for up to 72.2% of the training set, and 44.4% for the validation set of wines, respectively. The Sangiovese wines (n=19) were split into two sub-groups (Sang-Romagna, n=12 and Sang-Tuscany, n=7) considering the indeterminacy of its origins, which is disputed between Romagna and Tuscany. Although the classification of three grape varieties was problematic (Nerello Mascalese, Raboso and Primitivo), the remaining wines were almost correctly assigned to their actual classes.Conclusions: MIR spectroscopy coupled with chemometrics represents an interesting approach for the classification of monovarietal Italian red wines, which is important in quality control and authenticity monitoring.Significance and impact of the study: Authenticity is a main issue in winemaking in terms of quality evaluation and adulteration, in particular for origin certified/protected wines, for which the added marketing value is related to the link of grape variety with the area of origin. This study is part of the D-wine project “The diversity of tannins in Italian red wines”.
NEW PRIORITIES OF BOOK CULTURE OF THE INFORMATION SOCIETY: SUPPORTING BOOKS, READING AND CHILDHOOD (RESULTS OF THE III REGIONAL BOOK FORUM, SEPTEMBER 12–13, 2019)
Authors: Lizunova I. V.
Published: January 2020

The results of the scientific and practical arrangement with international participation – the book forum are presented, brief excerpts from the reports on the plenary session are given, topics of sections, speakers, and the range of issues addressed are named.
COLLECTIONS DEVELOPMENT TRENDS IN LIBRARIES OF THE SIBERIAN BRANCH OF THE RUSSIAN ACADEMY OF SCIENCES UNDER THE CONDITIONS OF SCIENTIFIC INSTITUTIONS SYSTEM OF MANAGEMENT TRANSFORMATION
Authors: Podkorytova N. I. , Lakizo I. G. , Artemyeva E. B.
Published: January 2020

Academic libraries in the region are organized according to the territorial and departmental principles as components of variously directed in their activities scientific centers of the Siberian Branch of the Russian Academy of Sciences (SB RAS). In the context of transformation of institutional management system, it is important to proceed with information and methodical support, rendered by SPSL SB RAS to SB RAS libraries. Besides, information support of educational and scientific interests of scholars and specialists needs higher level of integration of resources and service technologies for academic, university and regional scientific libraries, and this direction requires comprehension on the part of the library community.
INFORMATION SUPPORT FOR SCIENTISTS OF SCIENTIFIC CENTERS OF AGRICULTURAL PROFILE OF SIBERIA (1971–2019)
Authors: Melnikova T. N. , Garke T. M. , Kretova E. A.
Published: January 2020

The system of information support of agrarian science of Siberia, created by the Siberian scientific agricultural library, based on its information resources and intercommunications with agricultural libraries of the region, is analyzed. The results of the study of organizational and structural transformations in the management and information support for scientists in the modern period and the analysis of the status of libraries of research institutes are presented. The role of SibSAL as an interlink in maintenance of the united information space of agrarian science of Siberia is shown.
COMMUNICATIVE PRACTICES IN THE SOCIO-CULTURAL SPACE OF THE REGIONAL LIBRARY
Authors: Andronenko О. V. , Zhukovskaya L. N.
Published: January 2020

The article highlights the issues of organizing social and communicative practices by means of library activities. The experience of the State Universal Scientific Library of the Krasnoyarsk Territory on forming communicative interaction of various social groups through information services, offices and the library communication system is considered.
Territorialidade da coleta seletiva de resíduos sólidos: estudo de caso na cidade do Rio de Janeiro como subsídio à gestão pública
Authors: Gil Moises Leão , De Almeida Marcelo Pompermayer , Andrade Claudia Daza , Mello Sidney Luiz de Matos , Ávila Giovani Manso , Da Fonseca Estefan Monteiro
Published: January 2020

Uma análise territorial do município do Rio de Janeiro é apresentada com o objetivo de contribuir com o planejamento da coleta seletiva de resíduos sólidos e a tomada de decisão na gestão pública de limpeza urbana. A metodologia aplicada levou em consideração dados primários e secundários do atual sistema de coleta de resíduos sólidos no contexto da geografia metropolitana, cruzando essas informações com os dados de infraestrutura viária, demografia e perfil socioeconômico da população municipal, por meio de ferramentas de geoprocessamento. Estas informações, conjugadas e espacializadas, indicaram que o uso de diferentes modais, conforme as características de cada região, podem otimizar o processo de coleta, reduzindo custos da operação e melhorando a prestação de serviços. Esses resultados corroboram a importância da análise de dados geográficos para a otimização de recursos, eficiência e qualidade dos programas de coleta seletiva, tendo em vista o atendimento à Política Nacional dos Resíduos Sólidos.
Uma revisão de literatura sobre o design e planejamento de centros de distribuição
Authors: Guimarães Marina Cardoso , Tortorella Guilherme Luz
Published: January 2020

Destaques: Dadas às dificuldades de implementação prática de um projeto de Centro de Distribuição (CD), torna-se essencial fornecer um estudo elaborado de projeto de CD. Portanto, esse estudo busca responder as questões de pesquisa relacionadas a as principais decisões para projetar e planejar os CD e quais são as características, vantagens e barreiras de tais decisões.Objetivo: Identificar os principais métodos de projeto e planejamento de CD, consolidando suas características, dificuldades, destacamento de lacunas e oportunidades de pesquisa.Desenho / Metodologia / Abordagem: A metodologia deste trabalho é uma revisão sistemática da literatura e em três etapas, que são: (i) definição do portfólio bibliográfico e eixos de pesquisa; (ii) análise bibliométrica; (iii) análise e discussão de lentes teóricas, apresentando lacunas e oportunidades de pesquisa. Os artigos recuperados e as conclusões desta pesquisa são restritos ao período de busca até julho de 2018.Resultados: Este estudo descreve como o conceito de projeto de implantação de CD foram aplicados, quais métodos são propostos e quais dificuldades foram encontradas na implantação e projeto, de acordo com a literatura. Como resultado, apesar do consenso da importância prática do projeto de CD, a maioria das pesquisas avalia as etapas do projeto de forma isolada. Os estágios de definição da localização e o processo de separação de ordens são os mais mencionados. E por fim, o contexto e a rede de distribuição são pouco considerados na análise das decisões do projeto do CD.Limitações da investigação: O estudo é decorrente da pesquisa de artigos científicos provenientes de bases de dados específicos e analisado sob a perspectiva da lente teórica de redes de distribuição. Portanto, a análise da literatura através de outras perspectivas pode apresentar outros resultados e lacunas de pesquisa.Implicações práticas: Em termos práticos, a pesquisa avalia como ocorre o planejamento e implementação de CD no contexto das redes de distribuição, dessa forma, permite auxiliar os gestores nas tomadas de decisões durante o projeto de novas instalações de CD, garantindo melhores resultados na sua operação.Originalidade/valor: Poucas investigações analisam extensivamente a rede de distribuição e todas as fases de um planejamento de projeto de CD visando um segmento de negócio específico, tornando a aplicação prática menos viável, lacuna preenchida por esse estudo.
Análise da gestão de estoque em uma farmácia hospitalar em Marabá-PA: um estudo de caso
Authors: Pereira Raylane Monteiro , Felix Bianca Scarano , Monteiro Nathália Jucá , Fernandes Reimison Moreira
Published: January 2020

Para prestação de serviço na área da saúde, utiliza-se grande diversidade de materiais e medicamentos, o que faz com que a gestão de estoque seja um desafio para a organização hospitalar, considerando-se a necessidade de se disponibilizarem grandes quantidades de produtos variados. Cabe à farmácia hospitalar o gerenciamento desses itens, garantindo o uso seguro e racional, além de responder à demanda dos pacientes. Desta maneira, o controle eficaz dos estoques, com dados confiáveis, resulta em um bom andamento dos processos operacionais de materiais na instituição. Este trabalho tem como objetivo classificar os medicamentos da farmácia hospitalar através da classificação XYZ, calcular os indicadores de gestão (acurácia, estoque de segurança, giro de estoque e ponto de ressuprimento) para os cinco medicamentos com mais saída. Analisa-se, assim, o sistema de estoque atual para propor melhorias para o controle gerencial dos medicamentos da farmácia. O presente trabalho constitui um estudo de caso efetivado em uma farmácia hospitalar do hospital municipal de Marabá-PA. Os principais dados foram coletados por meio de verificação dos históricos de saídas dos medicamentos, conversas com os funcionários envolvidos no setor e observação do trabalho. A metodologia seguida mostrou-se adequada, já que gerou resultados diante do proposto para o trabalho. Verificou-se que o trabalho conseguiu atingir seus objetivos, pois os medicamentos foram classificados em XYZ, e, dos medicamentos de classe Z, cinco dos que obtiveram mais saída foram selecionados para que os indicadores fossem calculados. A partir dos resultados dos indicadores, observou-se que o serviço prestado pela farmácia, apesar de funcionar, está comprometido. Apesar das dificuldades encontradas, como as lacunas nos dados históricos, os quais resultaram na eliminação de alguns medicamentos, o trabalho concluiu seu objetivo e se configura como mais uma fonte de pesquisa para a gestão de estoques, desta vez em uma farmácia hospitalar pública, de extrema importância para o sistema de saúde e bom atendimento da população.
Estabelecimento das curvas-chave, geração das séries de vazões e estimativa das vazões máximas outorgáveis nos postos da sub-bacia Guapi-Macacu, RJ
Authors: Novo Eduardo Cochrane , Da Hora Mônica de Aquino Galeano Massera
Published: January 2020

A crescente demanda dos usos da água, o aumento populacional e a ocorrência de eventos climáticos extremos colocam a disponibilidade hídrica em foco. Em diferentes lugares do mundo, a água já não se encontra de forma tão abundante quanto há décadas. O abastecimento humano continua sendo a maior preocupação e a prioridade em políticas voltadas aos usos dos recursos hídricos, no entanto, setores como indústria, agricultura e energia demandam quantidades significativas de água, além da manutenção de sistemas ambientais dependentes desse recurso natural. Todas essas questões evidenciam o conflito vivido atualmente quanto ao uso e aproveitamento hídrico. Uma gestão integrada e sustentável são alicerces fundamentais para a manutenção qualitativa e quantitativa dos recursos hídricos. A outorga é um instrumento legal para a garantia do uso da água por tempo e volume determinado, seja para fins de captação ou lançamento de efluentes, e para sua aprovação, são necessários estudos hidrológicos para a estimativa da vazão a ser outorgada, também denominada de vazão máxima outorgável. O presente estudo definiu as curvas-chave e as séries de vazões diárias das estações fluviométricas inseridas na bacia hidrográfica do rio Guapi-Macacu, localizada na porção leste da Baía de Guanabara. Com base nos resultados, propõe-se a adoção de uma nova vazão máxima outorgável,visando um cenário de escassez hídrica que garanta o uso integrado e sustentável da água na bacia.
El tratamiento histórico de cuatro locuciones adverbiales: a rastras, a raudales, a la derredor y al menos
Authors: Puertas Ribés Elia
Published: January 2020

El presente artículo pretende contribuir al estudio de la fraseología del español a través de una perspectiva diacrónica e historiográfica. Para ello, se analiza una pequeña muestra de locuciones adverbiales extraídas de un corpus epistolar, compilado por el grupo de investigación ‘Sociolingüística’, de la Universitat Jaume I. A partir de los ejemplos fraseológicos recogidos en ese corpus, se estudian diferentes fuentes lexicográficas con el propósito de contribuir a la historia particular de cada una de estas locuciones, incorporando así información histórica relevante de las unidades fraseológicas en los diccionarios.
Ortografía contrastiva a través de los dictados: propuesta didáctica para italófonos
Authors: González Vallejo Rubén
Published: January 2020

Si bien los manuales de español se centren en ejercicios de comprensión oral de elección múltiple o de cloze, es innegable el beneficio de trabajar con dictados de diversa índole en el aula, ya que facilita la adquisición de estructuras semánticas de la lengua en el discente a la vez que este realiza una identificación de las palabras para su posterior transcripción revisando la ortografía. El presente trabajo toma como referencia la premisa de que los dictados pueden ser un gran aliado para la adquisición de la ortografía como, por ejemplo, junto a otras actividades que presenten previamente el contenido; y se centra principalmente en una propuesta didáctica basada en una cohorte de dictados para un alumnado de origen italiano de nivel C1-C2 que engloba las convenciones ortográficas más importantes recogidas en la Ortografía de la lengua española de la RAE y en el Plan Curricular del Instituto Cervantes. El posterior trabajo del error y de la ortografía comparada del español y el italiano constituirán el segundo objetivo.
La perspectiva del recuerdo: Proust desde Ortega
Authors: Balaguer García Esmeralda
Published: January 2020

El artículo pretende dar cuenta del carácter del recuerdo en la novela En busca del tiempo perdido de Marcel Proust, teniendo en cuenta las reflexiones que Ortega escribe sobre Proust en 1923 y sobre la novela en 1925. La primera parte del escrito abordará las reflexiones de Ortega sobre la obra de Proust como ejemplo de la novela moderna. La segunda parte tratará de clarificar por qué el recuerdo se gesta como una estructura para recuperar el pasado y qué papel juegan el olvido y la memoria en el mecanismo del recordar.
Modeling Gerotor Pump Performance in Artificial Lift for Single-Phase and Multiphase Conditions
Authors: Ejim C. E. , Oshinowo L. , Xiao J.
Published: January 2020

Gerotors are positive displacement pumps and candidates for artificial lift in the oil and gas industry. This study evaluates the performance of a unique gerotor pump design under single-phase and multiphase conditions. The gerotor pump performance is modeled with computational fluid dynamics (CFD) to develop a virtual prototype of the multiphase performance behavior. The gas/liquid flow is modeled using a homogeneous multiphase approach.

A prototype 3D model of a 400 series gerotor pump suitable for application in a 5½-in. casing is developed. The pump volume displacement is consistent with that to be used in subsequent laboratory experimental tests and field prototype testing. Transient 3D CFD is used to simulate the gerotor pump performance under single-phase and multiphase flow conditions. The complex gerotor motion is modeled in CFD using a dynamic meshing technique. Pump rotor speeds applicable to the range of testing conditions were applied. The gas and liquid phase properties correspond to mineral oil and air at the prototype test conditions.

The results of the gerotor pump performance are presented for single-phase and multiphase conditions over a range of gas volume fractions (GVFs) from 0 to 0.75. The CFD results show that the flow rate decreases approximately linearly with pump differential pressure, which is typical of positive displacement pumps. Pump performance and efficiency curves are developed relating the pump differential pressure and flow rate. The CFD model methodology is presented with consideration to appropriate selection of the numerical methods, multiphase model, mesh design, dynamic mesh motion, and other aspects to improve the reliability of the numerical simulations. For the same differential pressure, increasing the GVF decreases the gerotor total pumping volume rates. The results establish a first baseline for the pumping system for subsequent comparison with physical model testing to ascertain gas/liquid handling capability of the pump for further optimization for field application.

This study evaluates and highlights the potential applicability of gerotors as an alternative artificial lift technology for multiphase pumping. This technology with further development in addition to its inherent mechanical simplicity and compactness can serve as a promising candidate for surface and downhole multiphase pressure boosting for production in the oil and gas industry.
Radioactive Depth Marker Emplacement and Survey for Early Subsurface Geomechanical Model Calibration: Learnings from a Successful Ultra-HPHT Deployment
Authors: Banks John , Tourny David , Shotton Peter , Sampson Tim
Published: January 2020

Ultra-high-pressure high-temperature (uHPHT) reservoirs undergo extreme pressure depletion during their production life cycle. This results in significant reservoir compaction and consequent overburden subsidence with major consequences for wellbore mechanical integrity, safety, and field economics. However, the use of underdetermined geomechanical models to accurately predict compaction-induced stress/strain changes on wellbores and its consequences during production time results in significant residual uncertainty. One method of measuring compaction-induced stress/strain changes in wellbore is by the emplacement and measurement of radioactive markers. Although it is long established in normal pressure reservoirs, it is rare in uHPHT projects.

The Culzean uHPHT gas-condensate field is located in the UK Central North Sea. To constrain geomechanical model compaction uncertainty, radioactive markers were deployed. The objective was to accurately acquire preproduction baseline measurements and subsequent changes through periodic measurements during production life. These accurate wellbore measurements would then be compared with the geomechanical model to help calibrate predicted to actual compaction. By doing so, the objective is to enable better informed decisions regarding well and field management. The Culzean uHPHT radioactive marker project comprised a planning phase and a preproduction safe deployment including a baseline survey phase. Subsequent repeat measurements are planned during field production life.

The emplacement and surveying of the subsurface radioactive markers for compaction monitoring in uHPHT reservoirs is a high value but nontrivial operation. In addition, much knowledge and experience of the methodology has been lost. This paper contributes to published literature by describing the successful emplacement and monitoring of subsurface radioactive markers on Culzean and aims to capture learnings and knowledge for future workers. Early detailed planning coupled with extensive testing is key to successful deployment. Timely engagement of all stakeholders and ensuring all decisions are aligned with safety and environmental considerations also contribute to realization of the project aims.
Development and Efficiency Testing of Sucker Rod Pump Downhole Desanders
Authors: Langbauer Clemens , Hartl Manuel , Gall Sergej , Volker Lukas , Decker Christian , Koller Lukas , Hönig Stefan
Published: January 2020

Tense economic situations push the demand for low-cost oil production, which is especially challenging for production in mature oil fields. Therefore, an increase in the meantime between failure and the limitation of equipment damage is essential. A significant number of wells in mature fields are suffering under sand by-production. The objective of this paper is to show the development process and the testing procedure of an in-house-built, effective downhole desander for sucker rod pumps on the basis of a sophisticated analytical design model.

In weak reservoir zones, often the strategy to prevent equipment damage due to sand by-production is the sand exclusion method using a gravel pack. Nevertheless, a certain amount of small sand grains still enter the wellbore and may damage the sucker rod pumping system over time. In early 2018, various types and sizes of downhole desander configurations were tested at the pump testing facility (PTF) at the University of Leoben (Montanuniversitaet Leoben). In a period of about 4 months, testing took place under near field conditions to find the optimum and most efficient design. The design optimization was focused on the geometry of the swirl vanes and the sand separation distance at the sucker rod pump intake. An analytical model provided the basis for geometric optimization. Concurrently, field tests of the in-house downhole desander were performed in the Vienna Basin that confirmed the findings of the tests at the PTF.

The test results have shown that the downhole desander design and the pumping speed are the most influencing parameters on sand separation efficiency. Poor design in combination with a wrongly selected pumping speed can reduce the sand separation efficiency to lower than 50%, while if all parameters are chosen correctly, the sand separation efficiency can be 95% or higher. The grain size distribution is the additional parameter that enables a decision and ranks the performance. The sensitivity analysis, performed for several downhole desander types, has shown the high dependency of the sand separation efficiency on the major desander design parameters. Proper selection of the components and operating parameters will contribute to an increase in the meantime between failures.

This paper will present the testing configurations, the development of the high-efficiency in-house downhole desander, and the sensitivity analysis performed on the design.
A modified single-armed microsurgical vasoepididymostomy for epididymal obstructive azoospermia: intraoperative choice and postoperative consideration
Authors: Liu Nachuan , Li Peng , Zhi Erlei , Yao Chencheng , Yang Chao , Zhao Liangyu , Tian Ruhui , Chen Huixing , Huang Yuhua , Yu Yuexin , Li Zheng
Published: January 2020

Background: To evaluate the clinical outcomes and the duration required for the sperm to return to the ejaculate after a modified single-armed 2-suture longitudinal intussusception vasoepididymostomy (SA-LIVE). Methods: From March 2015 to December 2018, 134 patients with epididymal obstruction azoospermia underwent the modified single-armed vasoepididymostomy at Shanghai General Hospital. The outcomes and clinical findings were documented and evaluated. The mean follow-up period was 17 (range: 3–36) months. Results: Patency was assessed by the return of sperm in the ejaculate. The overall patency rate was 55.2%, and the patency rates were 58.9%, 40.7%, 36.4%, and 58.9% for bilateral surgery, unilateral surgery, proximal anastomosis, and distal anastomosis, respectively. The average time to achieve patency was 4.11±2.74 months. In the first six months, 87.8% (65/74) patency patients reported sperm in the ejaculate. The overall pregnancy rate was 40.9% (29/66) at the follow-up of 3–36 months, and the natural pregnancy rate was 30.3% (20/66). The natural pregnancy rate was 32.1% post-bilateral surgery and 33.3% for the site of distal anastomosis; surprisingly, it was 0% for the site of proximal anastomosis. Conclusion: Modified SA-LIVE is safe and may achieve favorable patency and pregnancy rates. When double-armed sutures are not accessible, single-armed may be preferable. The expected patency time was within one year. Moreover, because of the low natural pregnancy rate for proximal anastomosis, sperm banking is preferred to SA-LIVE.
The reliability and validity of a slightly revised Chinese version simplified modified Rankin scale questionnaire
Authors: yuan Junliang , wang yunxiao , Hu Wenli , Bruno Askiel
Published: January 2020

Background The slightly revised English version simplified modified Rankin scale questionnaire smRSq(2011) was shown to be reliable, valid, and useful in scoring the modified Rankin scale (mRS) after stroke. Our aim was to assess the inter-rater reliability and validity of a novel Chinese version smRSq(2011). Methods The English version smRSq(2011) was translated into Chinese by a standard process. We recruited 300 consecutive hospitalized ischemic stroke patients in the department of neurology, Beijing Chaoyang Hospital. Six randomly paired raters scored the conventional mRS, the novel Chinese version smRSq(2011), the National Institutes of Health Stroke Scale (NIHSS), and the Barthel index (BI) in-person. Inter-rater reliability and validity were assessed. Results Among the 300 ischemic stroke patients, mean age was 64.9±12.1 years, and 220 (73%) were male. For inter-rater reliability of the smRSq(2011), the percent agreement among the paired raters was 87%, the kappa (κ) was 0.84 (95% CI, 0.79-0.88), and the weighted kappa (κw) was 0.96 (95% CI, 0.95-0.98). The percent agreement between the smRSq(2011) scores by the first rater and the conventional mRS scores by the second rater in each pair was 55%, κ=0.47 (95% CI, 0.40-0.54), and κw=0.91 (95% CI, 0.89-0.93). In construct validity testing, the Spearman’s correlation coefficients comparing the smRSq(2011) scores by the first rater with the NIHSS and the BI scores by the second rater were 0.83 (P<0.001) and -0.86 (P<0.001), respectively. Conclusions Our results show good clinimetric properties of the novel Chinese version smRSq(2011) in scoring the mRS in Chinese stroke patients. Further validation in other clinical settings, including in communities and by remote methods in China is warranted.
Stable intronic sequence RNAs (sisRNAs) are selected regions in introns with distinct properties
Authors: Jin Jing , He Ximiao , Silva Elena M
Published: January 2020

Background: Stable introns and intronic fragments make up the largest population of RNA in the oocyte nucleus of the frog Xenopus tropicalis. These stable intronic sequence RNAs (sisRNAs) persist through the onset of zygotic transcription when synchronous cell division has ended and the developing embryo consists of approximately 8000 cells. Despite their abundance, the sequence properties and biological function of sisRNAs are just beginning to be understood. Results: To characterize this population of noncoding RNA, we identified all of the sisRNAs in the X. tropicalis oocyte nucleus using published high-throughput RNA sequencing data. Our analysis revealed that sisRNAs, have an average length of ~360 bps, are widely expressed from genes with multiple introns, and are derived from specific regions of introns that are GC and TG rich, while CpG poor. They are enriched in introns at both ends of transcripts but preferentially at the 3’ end. The consensus binding sites of specific transcription factors such as Stat3 are enriched in sisRNAs, suggesting an association between sisRNAs and transcription factors involved in early development. Evolutionary conservation analysis of sisRNA sequences in seven vertebrate genomes indicates that sisRNAs are as conserved as other parts of introns, but much less conserved than exons. Conclusion: In total, our results indicate sisRNAs are selected intron regions with distinct properties, supporting a biological function in gene expression regulation.
Kinematic and Mechanical Analysis of the Ankle Rotating-Traction-Poking Manipulation
Authors: Chunyu Gao , Baojian Wang , Liguo Zhu , Gao Jinghua , Jianguo Li , Jian Li , Minshan Feng
Published: January 2020

Background: In China, the ankle rotating-traction-poking manipulation (RTPM) has been used to increase range of movement and reduce pain in patients with lateral ankle sprains. But no research so far has quantitatively analyzed the kinematic and mechanical data of RTPM therapy. Therefore, the purpose of the present study was to analyze the kinematics and mechanics of RTPM technique. Methods : A total of 60 volunteers who had ankle sprains participated in the study. A single physiotherapist specializing in RTPM worked with each of the subjects. Motion capture technology, self-developed mechanical gloves, and a data synchronization device were used to acquire kinematic and mechanical data during the RTPM. Results : The mean maximum force of the thumb, index finger, and middle finger during the rotating was 18.89 N, 10.26 N, and 9.51 N, respectively, that of the traction force was 18.61 N, 13.25 N, and 8.33 N, respectively, and that of the poking force was 26.5 N, 8.61 N, and 10.62 N, respectively. The average time of rotating for six circles was 11.36 s. The average linear velocity of rotating was 58.28 mm/s, and that of traction-poking was 23.81 mm/s. The average linear acceleration of rotating was 0.43 mm/s 2 , and that of traction-poking was 0.54 mm/s 2 . The average displacements of traction and poking were 36.94 mm and 22.44 mm, respectively. The average angle of traction and poking were 23.27° and 22.76°, respectively. Conclusions : The RTPM can be repeatable for clinical application, and also has features of gentleness, rhythmicity, and continuity.
Association between early childhood caries and intimate partner violence in 20 low- and middle-income countries: 2007-2017
Authors: Folayan Morenike Oluwatoyin , Obiyan Mary , Tantawi Maha El , Kemoli Arthur , Al-Batayneh Ola B. , Gaffar Balgis , Schroth Robert
Published: January 2020

Background: To determine the relationship between country level prevalence of interpersonal violence (IPV) and the prevalence of early childhood caries (ECC) in children aged 3-5-year-olds. Method: This was an ecological study using extracted IPV (physical, sexual and emotional) and ECC data for 3-5-year-olds in 20 low- and middle-income countries for the period 2007-2017. Linear regression analysis was used to assess the relationship between the percentage of 3-5-year-old children with ECC (outcome variable) and the four IPV indicators (physical, sexual, emotional and a combination of the three). The model was adjusted for the country’s Gross National Income GNI. Partial eta squared (as measure of effect size), regression coefficients, confidence intervals and p values were calculated. Results: The strongest association was between ECC prevalence and exposure to physical violence (partial eta squared= 0.01), followed by exposure to sexual violence (partial eta squared= 0.005), and exposure to all types of IPV combined (partial eta squared= 0.001). Exposure to emotional violence had the weakest association with ECC (partial eta squared < 0.0001). For 1% higher percentage of women reporting exposure to physical violence and percentage of women reporting all types of IPV combined, there was a 0.18% higher prevalence of ECC. For 1% higher prevalence of sexual violence, there was 0.22% higher ECC prevalence. For 1% higher prevalence of emotional violence, there was 0.04% higher ECC prevalence. Conclusions: Countries with high prevalence of IPV will likely also have high prevalence of ECC. This needs further studies.
Evidence of increased prevalence of Multiple Sclerosis: A Population-Based Study of Tehran Registry, 1999–2018
Authors: Almasi-Hashiani Amir , Sahraian Mohammad Ali , Eskandarieh Sharareh
Published: January 2020

Background: The epidemiological characteristics of Multiple Sclerosis (MS) in various studies have been investigated and studies suggested that there is a different geographic disparity worldwide. The present study conducted to investigate the longitudinal prevalence of MS in Tehran, Iran. Methods: The population-based study was conducted in Tehran, the capital of Iran from 1999 to 2018 based on the annual report data through the Iranian MS Society (IMSS) registry system. The age-standardized and crude prevalence proportions were estimated by applicant of population data, established from the Statistical Centre of Iran. Results: Totally 21,580 MS cases were registered and included in the analysis. Out of them, 24.99% (5,393 cases) was male and 75.01% (16,187 cases) was female. The mean age of MS onset was 28.8 years (S.D: 8.7). The age standardized prevalence proportion (ASP) of MS ranged from 73.7 (95%CI: 72.1-75.2) in 2006 to 137.6 (95% CI: 135.7-139.5) per 100,000 in 2018. The MS ASP- was estimated 54.1 (95%CI: 53.6-54.6) among males and 174.5 (95%CI: 173.6-175.4) per 100,000 among females. The age standardized female to male ratio of MS in study period was 3.03. Conclusion: Our finding suggested that the prevalence of MS in Tehran province is relatively high and the disease occurrence is more common in the under-40 age group than in the older ones. As in the rest of the world, the prevalence of the MS was higher in women, and the female to male sex ratio was 3.03 in our study.
Impact of COL6A4P2 gene polymorphisms on the risk of lung cancer in a Chinese Han population
Authors: Duan Ying , Liu Gaowen , Niu Fanglin , Li Jing , Yan Mengdan , Jin Tianbo , Chen Mingwei
Published: January 2020

Background The aim of this study was to investigate the effects of COL6A4P2 polymorphisms on lung cancer (LC) in Chinese Han population.Methods To examine whether variants of COL6A4P2 contribute to LC, five single nucleotide polymorphisms (SNPs) of COL6A4P2 were genotyped by Agena MassARRAY in 510 LC patients and 495 controls. Odds ratio (OR) and 95% confidence intervals (CIs) were calculated by logistic regression.Results We found that COL6A4P2 rs34445363 significantly increased the risk of LC in the alleles model (OR = 1.26, 95%CI: 1.01 - 1.58, p = 0.038). And rs34445363 also increased the LC risk under the log-additive model (OR = 1.26, 95%CI: 1.01 - 1.58, p = 0.041) with the multigene model analysis. Further stratification analysis showed that rs34445363 increased the LC risk under the log-additive model (OR = 1.42, 95%CI: 1.03 - 1.95, p = 0.033) in people aged ≤ 61; and rs61733464 was associated with a decreased LC risk in the log-additive model (OR = 0.72, 95%CI: 0.52 - 0.99, p = 0.048) in people aged ≤ 61. We also found that the mutations of rs34445363 and rs77941834 were associated with increased LC risk in the codominant model (rs34445363, GA vs. GG, OR = 1.73, 95%CI: 1.04 - 2.86, p = 0.034; rs77941834, TA vs. TT, OR = 1.88, 95%CI: 1.06 - 3.34, p = 0.032) in females.Conclusions This study provided an evidence for polymorphisms of COL6A4P2 gene associated to the development of LC, also a new insight into etiology of LC.
Comparative profiling of chromatin open state of various cells and tissues for dissecting the epigenetic causes of various biological processes
Authors: Wu Jian , Gao Jinliang , Zhang Shuyan , Luo Tao , Dai Wei , Ling Jianhui , Wang Jinke
Published: January 2020

Background The comparative study of chromatin open state of various cells and tissues is helpful for dissecting the epigenetic causes of various biological and pathological processes such as development and tumorigenesis. This study comparatively characterized the chromatin open regions (CORs) of two normal human cell lines (HL7702 and MRC-5), nine human cancer cell lines (GM12878, HepG2, PANC-1, A549, HT29, SKOV3, SiHa, C-33A, and HeLa), one mouse cancer cell line (Hepa1-6), and healthy mouse liver tissue with SALP-seq.Results This study therefore made a set of systematic and useful COR profiles of human and mouse cells and tissues. These COR profiles were used to explore the possible epigenetic bases of several interesting scientific problems, including how chromatin state changes contribute to tumorigenesis, how the cancer-related mutation hotspots are formed, why fibroblast was most widely used to prepare iPSCs, and how HPV subtypes differently affect the chromatin structure of cervical cells. The results revealed that the comparative COR profiling can shed new insights into the potential molecular mechanisms underlying these important biological and pathological processes. The comparative COR profiling also demonstrated transcription factors differentially dominate various biological and pathological processes. At last, the comparative COR profiling uncovers new potential markers or targets for cancer diagnosis and therapy.Conclusions The comparative COR profiling with our developed SALP-seq technique can be used to uncover epigenetic bases and molecular mechanisms underlying various biological processes.
Prox1 gene transfer combined with voluntary exercise improves dystrophic muscle fragility in Mdx mice
Authors: Monceau Alexandra , Delacroix Clément , Lemaitre Mégane , Agbulut Onnik , Furling Denis , Klein Arnaud , ferry arnaud
Published: January 2020

Background Voluntary exercise can improve skeletal muscle fragility, i.e. higher susceptibility to contraction induced-injury, as shown by a greater force drop following lengthening contractions, in the dystrophic Mdx mice as compared to healthy mice with dystrophin. This beneficial effect is related to the activation of the calcineurin activation. Unfortunately, voluntary running only partly rescued fragility, so it would be interesting to combined the effects of exercise, for example, with those of others treatments activating the calcineurin pathway and promoting slow and more oxidative fibres. This is of particular interest because slow muscle fibres are apparently less affected and genetic or pharmacological treatments promoting slow and more oxidative fibres are been shown to be beneficial in the Mdx mice. Methods Here, we tested whether voluntary exercise (1 month of running in a wheel) combined with Prospero-related homeobox factor 1 gene ( Prox1) transfer would better improve functional dystrophic features in Mdx mice as compared to the voluntary exercise single approach. Prox1 is known to promote the promotion of slow contractile gene program in healthy muscle. Results We found that Prox1 transfer promoted slower molecular and functional contractile features in both voluntary exercised and sedentary Mdx mice. However, it improved fragility only in exercised Mdx mice. Moreover, Prox1 transfer reduced absolute maximal force production by causing reduction in muscle weight in both exercised and sedentary Mdx mice. Conclusion In conclusion, our results indicate that the beneficial effects of voluntary exercise and Prox1 transfer on fragility are additive in Mdx mice.
Inequality in Health: Correlation Between Poverty and Injury – A Comprehensive Analysis Based on Income Level in Taiwan: A Cross-sectional Study
Authors: Lin Yi-Chang , Chung Chi-Hsiang , Pai Lu , Tsai Chien-Sung , Chien Wu-Chien , Lin Chih-Sheng
Published: January 2020

Background For better health promotion in Taiwan, it needs an action to reduce health inequality; therefore a comprehensive monitoring on social determinants and health is urgent. Is income the obstacle to influence the health after Taiwan instituted national health insurance in 1995? We compared the characteristics of accident injuries for patients classified with low-income and non-low-income who required inpatient care. Methods We collected accident injury inpatient cases from 1998 to 2015 from the Health and Welfare Data Science Center, Ministry of Health and Welfare and categorized the patients as low-income and non-low-income. Chi-square tests, Fisher exact tests, an independent samples t-test, and percentages were used to identify differences in demographics, cause for hospitalization, and other hospital care variables. Results Between 1998 and 2015, there were 74,337 low-income accident injury inpatients, which represented 1.6% of all injury event inpatients. The hospitalization mortality rate for the low-income group was 1.9 times higher than that of the non-low-income group. Further, the average length of hospital stay (9.9 days), average medical expenses (1,681 USD), and mortality rate (3.6%) for the low-income inpatients were higher than those of the non-low-income group (7.6 days, 1,573 USD, and 2.1%, respectively). Among the common injury causes, the percentage of injuries from “medical malpractice,” “fall,” “suicide,” and “homicide” were higher for the low-income group than that for the non-low-income group. Conclusions Despite National Health Insurance coverage, we found a higher hospitalization rate, longer average length of hospital stay, and a higher mortality rate in the low-income group. These findings support our hypothesis that there is a correlation between health and income level, resulting in health inequality. Achieving health care equality may require collaboration between the government and private and nonprofit organizations to increase awareness of this phenomenon.
Comparative Evaluation of Keyhole Technique and Delta Technique for Cervical Disc Herniation: a retrospective comparative cohort study.
Authors: Yu Tong , Wu Jiu-Ping , Zhang Jun , Yu Hai-Chi , Liu Qinyi
Published: January 2020

Background p-PECD is an effective strategy for cervical diseases which working cannula ranges from 3.7 mm to 6.9 mm. However, no studies were performed to compare the clinical outcomes of keyhole technique (diameter of 3.7 mm) and delta technique (diameter of 6.9 mm) in CDH patients. The purpose of this study was to compare the clinical outcomes of unilateral cervical disc herniation (CDH) patients treated with posterior percutaneous endoscopic cervical discectomy (p-PECD) applying the keyhole technique with those treated with the delta technique.Methods From January 2016 to June 2018, totally 28 consecutive patients presented with single-level CDH who received p-PECD using the keyhole technique or the delta technique were enrolled in this study. Patients were evaluated neurologically pre- and postoperatively. The clinical outcomes, including the operation time, the hospitalization, the visual analogue scale (VAS) and the modified MacNab criteria, were evaluated. Cervical fluoroscopy, CT, and MRI were performed during follow up.Results In both groups, faster “V” point identification, more quickly overlying soft tissue removal and laminoforaminotomy, and shorter operative time, were found in the delta group. Postoperatively, the VAS and MacNab scores of the two techniques were improved significantly. Nevertheless, the differences between the two groups were not significant (P>0.05). One case suffered nerve root outer membrane torn in delta group.Conclusion Both keyhole technique and delta technique are effective methods for CDH in selected patients, and there is no significant difference in clinical outcomes. Delta technology is superior to keyhole technology in the efficiency of “V” point identification, overlying soft tissue removal and spinal cord injury prevention. Furthermore, delta technology is inferior to keyhole technology in anterior decompression of the intervertebral foramen.