bluuebunny/crossref_metadata_2025 huggingface dataset:
Challenges of teaching English as an additional language in high schools in Cambodia
Authors: Boy Vibol , Water Tineke
Published: December 2023

As English is a lingua franca in Southeast Asia, the teaching of this international language has been identified as an important educational activity in Cambodia. This study examined the challenges of teaching English as an additional language in four public high schools in Cambodia. It investigated the significance of various aspects of the school environment and the attributes of teachers toward English language teaching. A mixed methods design was employed, and data were collected through a survey and semi-structured interviews. The findings showed that a dated curriculum, classroom overcrowding, immovable furniture, limited resources, and a lack of professional development contributed to the challenges in teaching English in Cambodian schools. The study concludes with recommendations for the Royal Government of Cambodia and relevant stakeholders to provide schools with sufficient funds, facilities, and teaching resources; offer professional development opportunities to teachers and staff; and update English course books.
Penser et nommer l’inclusion : un horizon pour questionner les pratiques professionnelles dans le champ muséal
Authors: Maczek Ewa , Viau-Courville Mathieu
Published: December 2023

As a national observatory and think tank on museums and heritage, the Office for Museum Cooperation and Information (OCIM) has for forty years conducted national, territorial and thematic surveys on the development of museums, heritage, and scientific, technical and industrial culture (PCSTI). It is dedicated to understanding how institutional and professional practices evolve and what are the new and emerging trends in the field, and to supporting museum professionals and institutions in developing their projects and missions. This article presents the first results of the surveys “Approches sociales et inclusives des musées et des lieux de culture scientifique” (Social and inclusive approaches to museums and scientific cultural spaces) (2020, n =74) and “Chiffres clés des acteurs du PCSTI” (Key statistics in the field of PCSTI) (2021, data 2020 – n = 196), both intended to show how public engagement is an integral part of professional practices in mediation in the field of PCSTI in France. The two surveys reveal different ways in which inclusion and participation are embodied in the museum context, with their strengths and limitations. The article reflects on the place of ideas such as inclusion in the design of public engagement programs and strategies and how in recent years the vocabulary has evolved from using expressions like “facing the publics” or “for the publics” to the more inclusive “with the publics.” Who do we include under the umbrella expression “with the publics”? What methods can be used –whether new or not– to encourage public participation and inclusion in museums? How do these methods impact on professional mediation practices, exhibition design, management, and more generally museum thinking? Participatory museum, inclusive museum, citizen museum, museum as forum: what are the possible developments? This article provides insight on the relationship between the museum and the public, their roles and levels of engagement; whether the hope of “being inclusive” or “more inclusive” not as a turnkey project but very much as the spark that ignites a gradual shift with lasting impacts.
L’accueil au musée des publics en situation de handicap ou le long chemin vers un musée accessible
Authors: Reichhart Frédéric
Published: December 2023

The new definition of a museum put forward in 2022 by the International Council of Museums (ICOM) affirms the importance of a museum “open to the public, accessible and inclusive” and that “fosters diversity and sustainability”: the principles of accessibility, inclusion and participation are becoming a requirement as new norms for a museal institution and the evolution of its role and missions. They embody the necessary conditions to dust off the image of a cloistered museum, disconnected from its publics, and to build a welcoming museum space for active engagement with all publics. Still, beyond the affirmation of this political discourse, accessibility, whether seen by professionals as an injunction or a conviction, indeed an opportunity, is lagging; a study conducted in France in 2017 on accessibility to the culture for people with disabilities shows a number of difficulties in accessing culture, which throws the museal offer into question: how is the accessible offer structured for visitors with disabilities? And what is its participatory scope? To answer these questions, this article proposes to outline the content and evolution of this offer. Thus, firstly, the aim is to describe and present the sociopolitical and ideological context of museum accessibility in France; it looks back at the influence of cultural democratization as well as the emergence of inclusive pressure and accessibility, bolstered since 1975 by a legal framework. Secondly, the article will focus on the evolution of welcoming publics with disabilities and the variety of arrangements made to unite accessibility and participation.
El Romanç d’Evast e Blaquerna i el concepte missional lul·lià: una aplicació pràctica a l’Amèrica del segle XVI
Authors: Pérez Castañeda Manel
Published: December 2023

Resum: Sovint s’ha assenyalat el Romanç d’Evast e Blaquerna d’utòpic. Amb aquest treball hem pretés desmentir aquesta idea, tot relacionant-la amb el fet que l’ideari missional que Llull exposa al Blaquerna es va dur a terme més de dos-cents anys després de la seua redacció. Així, hom pot veure l’ideari missional lul·lià com un evident referent de la pràctica missional de Bartolomé de Las Casas a l’Amèrica del segle XVI. L’estudi de les llengües i les cultures indígenes i el tracte entre iguals entre els missioners i els infidels, motiu pel qual és necessari l’ús de raons per damunt de l’ús de la força, convergeixen en la voluntat evangelitzadora d’ambdós protagonistes.Paraules clau: Llull, Blaquerna, missió, Las Casas, evangelitzacióAbstract: The Romanç d’Evast e Blaquerna has often been noted of utopic. In this work we have sought to disprove this idea, linking it to the fact that the missionary ideal that Llull exposes to the Blaquerna took place more than two hundred years after its writing. Thus, one can see the missionary ideal as Llull as a clear reference of Bartolomé de Las Casas’ missionary practice in 16th-century America. The study of indigenous languages and cultures and the treatment of equals between missionaries and infidels, which is why it is necessary to use reasons above the use of force, converge on the evangelizing will of both protagonists.Keywords: Llull, Blaquerna, mission, Las Casas, evangelization.Keywords: Llull, Blaquerna, mission, Las Casas, evangelization
Napoli, 1602: suore per sbaglio? Magia e scrittura come mezzi per uscire dall’emarginazione o condanna definitiva alla marginalità?
Authors: Compagna Anna Maria , Mazza Anna , Puigdevall Bafaluy Núria
Published: December 2023

Riassunto: Il focus è puntato sui monasteri femminili all’inizio del secolo XVII. Una monaca del convento napoletano della Maddalena è sottoposta a un processo per magia varia nel Tribunale del Santo Ufficio di Napoli, in seguito alla denuncia della badessa e delle monache del monastero. Una suora benedettina veneziana, chiusa nel monastero di Sant’Anna, trova nella scrittura la sua forma di rivalsa. La suora napoletana che aveva acquisito un suo spazio nella storia minuta, attraverso la pratica della magia, una sorta di potere, di rivalsa sulla sua emarginazione, finisce nuovamente ai margini della società per la condanna della pratica di cui è accusata. Diversamente la monaca veneziana, attraverso le sue opere, acquista una notorietà tale da avere un suo spazio nella storia del pensiero monacale femminile. Entrambe le vicende, comunque, si inquadrano nei giochi di potere contemporanei: potere sulle due protagoniste, potere politico, potere religioso, scontri interni alla chiesa, agli ordini di chierici, ai singoli monasteri; scontri che coinvolgono le alte sfere e non solo loro. Parole chiave: emarginazione, donne, suore, magia, scritturaAbstract: The focus is on women’s monasteries at the beginning of the 17th century. A nun of the Neapolitan monastery of La Maddalena is subjected to a trial by various magic in the Tribunal of the Holy Office of Naples, following the denunciation of the abbess and the nuns of the monastery. A Venetian Benedictine nun, closed in the monastery of Sant’Anna, finds her form of revenge in writing. The Neapolitan nun who had acquired her own space in minute history, through the practice of magic, a sort of power, of revenge on her marginalization, ends up once again on the margins of society due to the condemnation of the practice she is accused of. On the other hand, the Venetian nun, through her works, acquires a notoriety such as to have her own space in the history of female monastic thought. Both events, however, are part of contemporary power games: power over the two protagonists, political power, religious power, clashes within the church, the orders of clerics, individual monasteries; clashes involving the upper echelons and not only them.Keywords: marginalization, women, nuns, magic, writing
Dei Maestri e sui Maestri: ritorni alla filologia. Riflessioni per Costanzo Di Girolamo
Authors: Viel Riccardo
Published: December 2023

Record en homenatge de Constanzo di Girolamo
L’Atles català di Cresques: primi sondaggi lessicali
Authors: Dusio Cristina , Staccioli Letizia
Published: December 2023

Riassunto: Il presente contributo nasce nell’ambito della ricerca condotta per il progetto, diretto da Anna Radaelli e finanziato dalla “Sapienza”, Università di Roma: «Itinerari testuali nel Medioevo mediterraneo. La tradizione delle scritture di viaggio e dell’immaginario figurativo nell’orizzonte occitano-catalano». Nello specifico, vengono presentati i primi risultati derivanti dai sondaggi linguistici effettuati sull’Atlante catalano, (ms. Parigi, BnF, Esp. 30), in particolare sul lessico. La pluralità di fonti a cui attinge tale opera, infatti, si riflette e traspare nella mescidanza lessicale che la caratterizza. Da un punto di vista prettamente testuale, l’Atlante presenta uno stile medio ma mai sciatto, con una differenza tra la prosa della compilazione cosmografico-astronomica (trasmessa nelle tavole 1-2) e quella delle legende (copiate nelle tavole 3-6). Nella prima sezione si nota l’uso di un lessico di derivazione colta, in cui si rilevano hapax e calchi dal latino, e termini tecnici e di ambito settoriale; di contro, nelle legende e nei toponimi il lessico risente anche degli influssi delle lingue parlate in quel tempo nel bacino del Mediterraneo, tra cui l’arabo. Parole chiave: Atlante catalano, testo, lessicoAbstract: This contribution arises from the research conducted as part of the project, directed by Anna Radaelli and financed by “Sapienza”, University of Rome: «Itinerari testuali nel Medioevo mediterraneo. La tradizione delle scritture di viaggio e dell’immaginario figurativo nell’orizzonte occitano-catalano». Specifically, it presents the first results of the linguistic surveys carried out on the Catalan Atlas, (ms. Paris, BnF, Esp. 30), particularly on the lexicon. The plurality of sources from which this work draws is reflected in the lexical mixture that characterises it. From a purely textual point of view, the Atlas shows an average but never sloppy style and a difference between the prose of the cosmographic-astronomical compilation (conveyed in Tables 1-2) and that of the captions (copied in Tables 3-6). In the first section, the use of a cultured lexicon can be noticed, with hapaxes and casts from Latin, and technical and sectorial terms; on the other hand, in the captions and the toponyms the lexicon is also influenced by the languages spoken at the time in the Mediterranean basin, including Arabic. Keywords: Catalan Atlas, text, lexicon
Aragonesi, castigliani e catalani: il Mediterraneo di Pero Tafur
Authors: Zinato Andrea
Published: December 2023

Riassunto: Nel corso dei suoi viaggi marittimi e terrestri per l’Italia, il Levante, l’Oriente e il Nord Europa, dei quali ha lasciato precisa memoria nelle sue Andanças e viages, Pero Tafur si dimostra un osservatore attento e perspicace: non solo esibisce le sue conoscenze tecniche arricchite da descrizioni assai precise e puntuali di rotte, porti, modalità di navigazione, tipologie di imbarcazioni e via dicendo, ma soprattutto descrive il Mediterraneo nel quale le flotte aragonesi-catalane, castigliane, veneziane, genovesi ed ottomane si scontrano per imporre la loro supremazia militare e commerciale. Tafur, inoltre, racconta la complessità del mondo mediterraneo, le strategie geo-politiche delle potenze marinare, le alleanze, le guerre, l’incontro-scontro di nazioni e popoli assai diversi, usi e costumi anche alimentari, le misure per combattere le pestilenze e via dicendo. Il racconto delle sue esperienze (con precisi riscontri nelle fonti a lui contemporanee) costituisce un documento assai prezioso sulla realtà del Mediterraneo nella prima metà del XV secolo.Parole chiave: Pero Tafur, Andanças e viages, mondo mediterraneo, XV secolo, inclusione, eredità culturaleAbstract: In the course of his travels by land and sea through Italy, the Levant, the Orient and Northern Europe, of which he left precise records in his Andanças e viages, Pero Tafur proves to be an attentive and perceptive observer: not only does he display his technical knowledge enriched by very precise and punctual descriptions of routes, ports, navigation methods, types of vessels and so on, but above all he describes the Mediterranean in which the Aragonese-Catalan, Castilian, Venetian, Genoese and Ottoman fleets clash to impose their military and commercial supremacy. Tafur also recounts the complexity of the Mediterranean world, the geo-political strategies of the maritime powers, the alliances, the wars, the meeting-clash of very different nations and peoples, the customs, even those related to food, the measures to combat plagues and so on. The account of his experiences (with precise references in sources contemporary to him) constitutes a very precious document on the reality of the Mediterranean in the first half of the 15th century.Keywords: Pero Tafur, Andanças e viages, Mediterranean world, 15th century, inclusion, cultural heritage
Parole del mare. Il contributo catalano al lessico sardo della pesca
Authors: Strinna Giovanni
Published: December 2023

Riassunto: La Sardegna, per motivi storici, non possiede tradizioni nell’ambito marinaresco, ma i suoi abitanti hanno lasciato che fossero i popoli stranieri (dapprima catalani e spagnoli, poi campani, siciliani e liguri) ad occuparsi delle professioni relative al mare: da qui discende il fatto che anche il lessico pertinente a questa sfera lessicale è composito ed è stato interamente preso a prestito da altre lingue. Il contributo si concentra in particolare sugli apporti del catalano al lessico nautico e marittimo, che appaiono cospicui e pervasivi, e coprono vari ambiti che vanno dai vocaboli del porto e della pesca, con le relative attrezzature, fino alle più umili denominazioni dei pesci di mare, dei crostacei e dei molluschi. Parole chiave: lessico marinaresco, ittionimia, lingua sardaAbstract: Sardinia, for historical reasons, does not have traditions in the maritime field, but its inhabitants allowed foreign peoples (first Catalans and Spaniards, then fishermen from Campania, Sicily, and Liguria) to take care of professions related to the sea. As a result, the relevant lexicon in this linguistic sphere is composite and entirely borrowed from other languages. The essay specifically focuses on the contributions of Catalan to the nautical and fishing lexicon, which appear substantial and pervasive, covering various areas ranging from port and fishermen terms, along with their respective equipment, to the humblest names of sea fish, crustaceans, and mollusks.Keywords: Maritime lexicon, ichthyonymia, Sardinian language
«Tutto che mi resta è gia perduto»: la influència de Salvatore Quasimodo en l’obra de Ponç Pons
Authors: Pereira Rueda Andrea
Published: December 2023

Resum: L’objectiu d’aquest treball és estudiar la influència de la poesia de Salvatore Quasimodo en l’obra de Ponç Pons. El treball es divideix en tres parts. En la primera, s’analitzaran les influències literàries del poeta menorquí durant la seva primera etapa poètica. Malgrat no trobar ressons de l’autor italià, aquest apartat ens servirà per explicar l’origen de la reivindicació de la seva identitat menorquina, que és un aspecte que lliga amb la literatura de Quasimodo. En la segona i tercera part de l’estudi, s’analitzarà la influència de Quasimodo en la segona i tercera etapa literària de Ponç Pons. L’anàlisi, doncs, serà diacrònic i amb una perspectiva comparatista.Parole chiave: Ponç Pons, Salvatore Quasimodo, illomania, identitat menorquina, literatura italianaAbstract: The aim of this work is to study the influence of Salvatore Quasimodo’s poetry on Ponç Pons’s literature. The work is divided into three parts. In the first, the literary influences of the Menorcan poet during his first poetic stage will be analysed. Despite not finding echoes of the Italian author, this section will serve to explain the origin of the vindication of his Menorcan identity, which is an aspect that links with the literature of Quasimodo. In the second and third part of the study, the influence of Quasimodo in the second and third literary stage of Ponç Pons will be analyzed. The analysis will therefore be diachronic and with a comparative perspective.Keywords: Ponç Pons, Salvatore Quasimodo, island man, Menorcan identity, Italian literature
La hipertextualitat i la intermedialitat en Odissea, el viatge de Ningú (2017), d’Elies Monxolí
Authors: Cano Mateu Josep Àngel , Hernández Garcia Xavier
Published: December 2023

Resum: L’Odissea d’Homer ha donat lloc a centenars de versions, traduccions o reescriptures, i també en l’àmbit musical o l’artístic. Com destaca Gérard Genette (1982), és un dels hipotextos més utilitzats que ha inspirat grans obres com l’Eneida o l’Ulisses, de James Joyce. També Odissea, el viatge de Ningú, d’Elies Monxolí: una nova lectura del relat homèric ssobre les traduccions de Carles Riba i Joan Francesc Mira, i que hi incorpora referències a Ausiàs Marc, Dante Alighieri, Salvador Espriu i Vicent Andrés Estellés, entre d’altres. A aquesta riquesa hipertextual, s’hi suma la música, que s’adapta al text i hi integra al·lusions a Lluís Llach i a Raimon. Els collages de Pere Salinas completen aquesta creació que amalgama literatura, música i art plàstic. L’objectiu d’aquest article és analitzar la hipertextualitat d’aquesta obra a partir de Genette, i les relacions intermedials entre les diferents disciplines artístiques que la conformen, seguint les tipologies de Werner Wolf (1999).Paraules clau:  hipertextualitat, intermedialitat, Homer, Odissea, El Viatge de Ningú reescripturesAbstract: Homer’s Odyssey is a major pillar of the Western literary canon that has resulted in hundreds of versions, translations, or rewritings, both from a literary point of view and from a musical or artistic point of view. In fact, as Gérard Genette (1982) points out, it is one of the most commonly used hypotexts, which have inspired great works such as the Aeneid and James Joyce’s Ulysses. Also Odissea, el viatge de Ningú, by Elies Monxolí: a new reading of the Homeric story based on the translations of Carles Riba and Joan Francesc Mira, that incorporates references to Ausiàs Marc, Dante Alighieri, Salvador Espriu and Vicent Andrés Estellés, among others. To this hypertextual richness is added the music, which is adapted to the text and, at the same time, integrates allusions to Lluís Llach and Raimon. The collages of Pere Salinas complete this interdisciplinary creation that amalgamates literature, music and plastic art. The aim of this article is to analyse, on the one hand, the hypertextuality of this work, following Genette, and, on the other, the intermediality relations between the different artistic disciplines that conform it, following the typologies developed by Werner Wolf (1999).Keywords: hypertextuality, intermediality, Homer, Odissea, el viatge de Ningú, rewritings
Mediterrani i apocalipsi en la literatura catalana de ciència-ficció
Authors: Martínez-Gil Víctor
Published: December 2023

Resum: L’objectiu d’aquest article és analitzar la presència del mediterranisme, entès com a doctrina d’identificació col·lectiva,  en la literatura catalana de ciència-ficció sobre la fi del món. L’article estableix les possibles relacions entre els motius que provoquen l’apocalipsi (guerra mundial destructora, invasió d’extraterrestres, motius ecològics) i les diferents imatges del Mediterrani com a refugi de valors clàssics i vitals (durant la postguerra i fins als anys setanta), com a imatge de la societat desapareguda (durant l’exili i en ecoficcions dels anys setanta) o, en la ficció climàtica apocalíptica i en la ficció de l’Antropocè, com a massa d’aigua amenaçadora o com subjecte de nous valors d’identificació. Aquest recorregut pot ajudar a entendre els canvis ideològics esdevinguts entre la guerra freda, la postmodernitat i l’actualitat.Paraules clau: ciència-ficció, apocalipsi, mediterranisme, postmodernitat, Literatura catalanaAbstract: The aim of this paper is to analyse the presence of Mediterraneanism, that is, a collective identification way of thinking, in Catalan science-fiction literature about the end of the world. The paper lays out the possible relationships between what causes the apocalypse (a destructive world war, an alien invasion, environment issues) and the different portraits of the Mediterranean as the sanctuary of classical and life values (literature after the Spanish Civil War and until the 70s), as the portrait of a lost society (literature of the Exile period and 70s eco-fiction), or as a menacing water body or a subject of new identity values in apocalyptic climate fiction and Anthropocene fiction. This paper can help understand the ideological changes that happened between the Cold War, Postmodernity, and the present time.Keywords: Science fiction, Apocalypse, Mediterraneanism, Postmodernity, Catalan literature
Ressenya a Rafael Ferrer i Bigné, Escrits valencians, València, 2023
Authors: Sanchis Molla Hèctor
Published: December 2023

Ressenya a Rafael Ferrer i Bigné, Escrits valencians, ed. R. Roca, Institució Alfons el Magnànim, València, 2023, 167 pp., ISBN: 978-84-1156-019-1Review to Rafael Ferrer i Bigné, Escrits valencians, ed. R. Roca, Institució Alfons el Magnànim, València, 2023, 167 pp., ISBN: 978-84-1156-019-1
Functional and pharmacological analyses of visual habituation learning in larval zebrafish
Authors: Lamiré Laurie Anne , Haesemeyer Martin , Engert Florian , Granato Michael , Randlett Owen
Published: December 2023

Habituation allows animals to learn to ignore persistent but inconsequential stimuli. Despite being the most basic form of learning, a consensus model on the underlying mechanisms has yet to emerge. To probe relevant mechanisms, we took advantage of a visual habituation paradigm in larval zebrafish, where larvae reduce their reactions to abrupt global dimming (a dark flash). We used Ca2+ imaging during repeated dark flashes and identified 12 functional classes of neurons that differ based on their rate of adaptation, stimulus response shape, and anatomical location. While most classes of neurons depressed their responses to repeated stimuli, we identified populations that did not adapt or that potentiated their response. These neurons were distributed across brain areas, consistent with a distributed learning process. Using a small-molecule screening approach, we confirmed that habituation manifests from multiple distinct molecular mechanisms, and we have implicated molecular pathways in habituation, including melatonin, oestrogen, and GABA signalling. However, by combining anatomical analyses and pharmacological manipulations with Ca2+ imaging, we failed to identify a simple relationship between pharmacology, altered activity patterns, and habituation behaviour. Collectively, our work indicates that habituation occurs via a complex and distributed plasticity processes that cannot be captured by a simple model. Therefore, untangling the mechanisms of habituation will likely require dedicated approaches aimed at sub-component mechanisms underlying this multidimensional learning process.
A machine learning-based model for clinical prediction of distal metastasis in chondrosarcoma: a multicenter, retrospective study
Authors: Wei Jihu , Lu Shijin , Liu Wencai , Liu He , Feng Lin , Tao Yizi , Pu Zhanglin , Liu Qiang , Hu Zhaohui , Wang Haosheng , Li Wenle , Kang Wei , Yin Chengliang , Feng Zhe
Published: December 2023

Background

The occurrence of distant metastases (DM) limits the overall survival (OS) of patients with chondrosarcoma (CS). Early diagnosis and treatment of CS remains a great challenge in clinical practice. The aim of this study was to investigate metastatic factors and develop a risk stratification model for clinicians’ decision-making.

Methods

Six machine learning (ML) algorithms, including logistic regression (LR), plain Bayesian classifier (NBC), decision tree (DT), random forest (RF), gradient boosting machine (GBM) and extreme gradient boosting (XGBoost). A 10-fold cross-validation was performed for each model separately, multicenter data was used as external validation, and the best (highest AUC) model was selected to build the network calculator.

Results

A total of 1,385 patients met the inclusion criteria, including 82 (5.9%) patients with metastatic CS. Multivariate logistic regression analysis showed that the risk of DM was significantly higher in patients with higher pathologic grades, T-stage, N-stage, and non-left primary lesions, as well as those who did not receive surgery and chemotherapy. The AUC of the six ML algorithms for predicting DM ranged from 0.911–0.985, with the extreme gradient enhancement algorithm (XGBoost) having the highest AUC. Therefore, we used the XGB model and uploaded the results to an online risk calculator for estimating DM risk.

Conclusions

In this study, combined with adequate SEER case database and external validation with data from multicenter institutions in different geographic regions, we confirmed that CS, T, N, laterality, and grading of surgery and chemotherapy were independent risk factors for DM. Based on the easily available clinical risk factors, machine learning algorithms built the XGB model that predicts the best outcome for DM. An online risk calculator helps simplify the patient assessment process and provides decision guidance for precision medicine and long-term cancer surveillance, which contributes to the interpretability of the model.
LINC00969 inhibits proliferation with metastasis of breast cancer by regulating phosphorylation of PI3K/AKT and ILP2 expression through HOXD8
Authors: Wen Xiaoyun , Hou Ya , Zhou Liang , Fang Xiansong
Published: December 2023

Background

Breast cancer (BC) is a malignancy that is inadequately treated and poses a significant global health threat to females. The aberrant expression of long noncoding RNAs (lncRNAs) acts as a complex with a precise regulatory role in BC progression. LINC00969 has been linked to pyroptotic cell death and resistance to gefitinib in lung cancer cells. However, the precise function and regulatory mechanisms of LINC00969 in BC remain largely unexplored.

Methods

Cell proliferation, migration, and invasion of BC cells were evaluated using CCK-8 and Transwell assays. Western blotting was employed to analyze the protein expression levels of HOXD8, ILP2, PI3K, t-AKT, and p-AKT.

Results

LINC00969 was drastically reduced in BC tissues LINC00969 overexpression markedly suppressed proliferation, migration, and invasion, and blocked PI3K and p-AKT protein expression in MCF-7 cells. Activation of the PI3K/AKT pathway reversed the suppressive effect of LINC0096 overexpression on the proliferation, migration, and invasion of MCF-7 cells. Moreover, LINC00969 overexpression enhanced HOXD8 and blocked ILP2 protein expression in MCF-7 cells. In contrast, activating the PI3K/AKT pathway had no effect on HOXD8 and blocked ILP2 protein expression in MCF-7 cells overexpressing LINC00969. HOXD8 knockdown enhanced ILP2, PI3K, and p-AKT protein expression, and the proliferation, migration, and invasion of MCF-7 cells co-transfected with si-HOXD8 and ov-LINC00969. LINC00969 regulated HOXD8 via binding to miR-425-5p.

Conclusion

LINC00969 inhibits the proliferation and metastasis of BC cells by regulating PI3K/AKT phosphorylation through HOXD8/ILP2.
Dose-response effect of L-citrulline on skeletal muscle damage after acute eccentric exercise: an in vivo study in mice
Authors: Ghozali Dhoni Akbar , Doewes Muchsin , Soetrisno Soetrisno , Indarto Dono , Ilyas Muhana Fawwazy
Published: December 2023

Background

Eccentric exercise may trigger mechanical stress, resulting in muscle damage that may decrease athletic performance. L-citrulline potentially prevents skeletal muscle damage after acute eccentric exercise. This study aimed to assess the dose-response effect of L-citrulline as a preventive therapy for skeletal muscle damage in mice after acute eccentric exercise.

Methods

This is a controlled laboratory in vivo study with a post-test-only design. Male mice (BALB/c, n = 25) were randomized into the following groups: a normal control (C1) (n = 5); a negative control (C2) with downhill running and placebo intervention (n = 5); treatment groups: T1 (n = 5), T2 (n = 5), and T3 (n = 5), were subjected to downhill running and 250, 500, and 1,000 mg/kg of L-citrulline, respectively, for seven days. Blood plasma was used to determine the levels of TNNI2 and gastrocnemius muscle tissue NOX2, IL-6, and caspase 3 using ELISA. NF-κB and HSP-70 expressions were determined by immunohistochemistry.

Results

Skeletal muscle damage (plasma TNNI2 levels) in mice after eccentric exercise was lower after 250 and 500 mg/kg of L-citrulline. Further, changes in oxidative stress markers, NOX2, were reduced after a 1,000 mg/kg dose. However, a lower level of change has been observed in levels of cellular response markers (NF-κB, HSP-70, IL-6, and caspase 3) after administration of L-citrulline doses of 250, 500, and 1,000 mg/kg.

Conclusion

L-citrulline may prevent skeletal muscle damage in mice after acute eccentric exercise through antioxidant effects as well as inflammatory and apoptotic pathways. In relation to dose-related effects, it was found that L-citrulline doses of 250, 500, and 1,000 mg/kg significantly influenced the expression of NF-κB and HSP-70, as well as the levels of IL-6 and caspase 3. Meanwhile, only doses of 250 and 500 mg/kg had an impact on TNNI2 levels, and the 1,000 mg/kg dose affected NOX2 levels.
Port-site Infection with Atypical Mycobacteria Post-laparoscopic Procedure: A Case Series
Authors: Vinodini C , Binu MG , Ramkumar S , Srinivasan T
Published: December 2023

Surgical site infections with atypical mycobacteria are uncommon but not unheard of. Atypical mycobacteria are abundantly present in soil and water and can cause infections when the immune system is compromised. We present four cases of atypical mycobacterial infections at the port site following laparoscopy. In the first case, a laparoscopic cholecystectomy, there was histopathologic evidence of mycobacterial infection, although the smear and culture tests were negative. The second case, post- laparoscopic sterilisation, also showed histopathologic evidence, but the smear test was negative. Similarly, the third case, post- laparoscopic appendectomy, had histopathologic evidence but a negative smear. The fourth case, a post-laparoscopic hernia repair, had histopathologic evidence, a positive smear, and positive culture. The Catridge-Based Nucleic Acid Amplification Test (CBNAAT) for Mycobacterium Tuberculosis (MTB) was negative for all four patients, indicating the absence of tuberculous infection. The first three patients were treated with conventional anti-tubercular treatment using four drugs: Isoniazid (INH), rifampicin, ethambutol, and pyrazinamide, along with an additional quinolone. The fourth patient was treated with a combination of Ciprofloxacin, Clarithromycin, and doxycycline. All four patients responded well to treatment. The use of tap water to dilute disinfectants is considered a risk factor for atypical mycobacterial infection.
Incidence and Risk Factors of Surgical Site Infections after Elective Gastrointestinal Surgery: A Prospective Cohort Study
Authors: Catherin Ainzin Maria , Shajahan Y , Preetha S , Vinod PB
Published: December 2023

Introduction: Surgical Site Infection (SSI) is defined as an infection that occurs within an incisional wound within 30 days following the procedure. SSI continues to be a significant contributor to extended hospital stays and elevated morbidity, with significant mortality even with well-equipped operation theaters with modern sterilisation techniques, surgical equipment, proper antibiotic cover, and newer surgical methods. Proper identification of the risk factors and modification, if possible, is the only way to optimise surgical outcomes and reduce SSI. Aim: To assess the incidence of SSI and analyse the risk factors associated with SSI. Materials and Methods: A prospective cohort study was conducted from March 2020 to March 2022 at a rural medical college in the coastal area of Alappuzha district of Kerala, India. Patients over 18 years of age admitted for elective gastrointestinal (GI) surgery for various indications were included. Those presenting with pre-existing infections other than the indication for surgery and those undergoing laparoscopic surgeries were excluded. Operations were performed on the third day after admission for all patients. The incidence of SSI and its relation with age, gender, smoking, diabetes, preoperative serum albumin, White Blood Cell (WBC) count, type and duration of surgery, American Society of Anaesthesiologists (ASA) physical status, and surgical wound were analysed using the Chi-square test and Fisher’s exact test. Results: On analysis of 216 patients, variables such as smoking, diabetes, preoperative low serum albumin, higher ASA physical status, contaminated and dirty wound, and prolonged duration of surgery were strongly associated with the development of SSI. Conclusion: Patients with risk factors such as smoking, diabetes, preoperative low serum albumin, higher ASA physical status, contaminated and dirty wound, and prolonged duration of surgery should receive special attention to optimise surgical outcomes and mitigate the risk of infection.
The Use of (O. Basilicum) Extract to Treat Litopenaeus vannamei Disease the Infected Bacteria Vibrio parahaemolyticus
Authors: Harlina Harlina , Saenong Muhammad , Syahrul Syahrul , Hamdillah Andi , Tangdilintin Inda Safitri
Published: December 2023

This research aims to treat vaname shrimp disease  infected with bacteriaVibrio parahaemolyticus. In this research, we used Completely Randomized Design (CRD) 4 treatments and 3 replications. The treatment being tested was the treatment of vaname shrimp disease by soaking in basil (O. basilicum) leaf extract with different concentrations, namely: Treatment A (0 mg/ml), treatment B (1.56 mg/ml), treatment C (3.12 mg/ml) and treatment D (12.5 mg/ml). The parameter observed was the number of bacterial coloniesV. parahaemolyticus maintenance media and in the hepatopancreas of vaname shrimp. Apart from that, observations were made on the survival rate of vaname shrimp and water quality parameters. The research results found that the best concentration in the treatment of diseaseV. parahaemolyticus in vaname shrimp at a concentration of 12.5 mg/ml with the lowest number of bacterial colonies in the rearing media, namely 1.20 x 102 CFU/ml. In the hepatopancreas of vaname shrimp, the lowest number of colonies was obtained at a treatment concentration of 12.5 mg/ml, namely 1.12 x 102 CFU/ml. The highest survival rate was obtained at a treatment concentration of 12.5 mg/ml of 86,67±5,77%. The range of water quality in research observations was obtained as follows salinity 28.72-29.05 ppt, temperature 26.71- 27.25OC, oxygen ranges from 5.72-7.81, pH 7.18-8.13 and ammonia 0.033-0.041ppm. Water quality during the research was in the optimal range for the life of vaname shrimp.
O PACTO FEDERATIVO E A IMPLEMENTAÇÃO DA POLÍTICA PÚBLICA DE SAÚDE NO BRASIL
Authors: Luiz Pase Hemerson , Dupuy Patella Ana Paula , Rodrigo Santos Everton
Published: December 2023

O direito à saúde é fundamento inerente à dignidade da pessoa humana, no entanto, é notória a dificuldade crescente de acesso da população aos serviços públicos dessa natureza, levando os cidadãos rotineiramente a apelar ao Poder Judiciário. Diante disso surge o seguinte questionamento: por que o Poder Judiciário é tão acionado para resolver questões de saúde pública cuja responsabilidade pela execução é do Poder Executivo? Visando responder ao problema, nossa hipótese é que há uma incongruência entre a institucionalização das competências dos entes federados e a composição orçamentária, que impede a implementação das políticas públicas de saúde. Objetiva-se esclarecer as repartições de competências e de receitas entre os entes federados para analisar a possível relação da sua incompatibilidade com a ineficiência administrativa do Estado. A análise inicia-se pela apresentação da legislação aplicável ao Sistema Único de Saúde, para explicitar a forma de operacionalização e a divisão de competências pelas prestações de saúde entre os entes federados. Depois disso, é realizado o estudo acerca da viabilidade de custeio da saúde pública no Brasil, esclarecendo as fontes de receita e as porcentagens de participação dos entes na arrecadação tributária nacional.
ORNITORRINCO RELOADED: uberização e virações contemporâneas na crise do capital
Authors: Canettieri Thiago
Published: December 2023

O presente artigo objetiva contribuir na avaliação crítica do atual arranjo do mundo do trabalho em decomposição decorrente das contradições internas do capital. Assim, investiga-se o processo chamado de uberização com foco nas formas de subsunção do trabalho e de sua exploração no momento contemporâneo da crise de acumulação do capital. Investiga-se as possíveis contribuições das formulações de Karl Marx a partir da tradição da chamada crítica do valor como chave de leitura. Dessa maneira, apresentamos aqui uma crítica das forças produtivas e as formas de dominação em curso. Para tanto, realizamos uma aproximação dessa corrente teórica com os escritos de Chico de Oliveira a fim de oferecer uma interpretação possível para o atual momento da reprodução crítica do capital.
REFUGIADOS DA ÁGUA: vulnerabilização e conflitos por acesso à água
Authors: Cesar O. Diniz Paulo , Monteiro Costa André , Rozendo Cimone , Gomes Ferreira José , José Rocha da Silva Flávio
Published: December 2023

Este artigo busca compreender como os processos de vulnerabilização socioambiental repercutiram nos conflitos com as populações atingidas pelo deslocamento compulsório nas obras da transposição do Rio São Francisco, fazendo com que essas se tornassem refugiadas da água. São analisadas três Vilas Produtivas Rurais (VPR’s), sendo duas do Eixo Leste – uma em Sertânia/PE (VPR Salão) e outra em Monteiro/PB (VPR Lafayete) – e a terceira no Eixo Norte, em São José de Piranhas/PB (VPR Irapuá I). Essas localidades foram afetadas pelo empreendimento, tendo como uma das questões centrais a dificuldade do acesso à água para consumo humano e produção por parte das famílias para lá transferidas. Utilizam-se, para este artigo, as metodologias de revisão bibliográfica, entrevistas em grupo, reuniões e visitas de campo às referidas VPR’s. Concluiu-se que a vulnerabilização social decorre das múltiplas formas de desterritorialização dessas famílias, rompendo vínculos sociais, culturais e ambientais das comunidades rurais, sem garantia do Estado frente às suas responsabilidades com o deslocamento forçado das famílias, o desmantelamento das áreas produtivas e o não acesso à água com a qualidade e a quantidade necessárias para o consumo humano e para a produção agrícola.
E quando a paisagem se tematiza? Considerações acerca das transformações ocorridas na cidade de Tiradentes-MG mediante as dinâmicas turísticas
Authors: Paula Karine Almeida , Faria Teresa Cristina de Almeida
Published: December 2023

O trabalho tem como objetivo analisar as transformações socioespaciais advindas da implementação de atividades turísticas na cidade de Tiradentes MG num contexto temporal. A cidade abriga um importante acervo histórico arquitetônico datado do período colonial e tem visto, por meio deste acervo, uma oportunidade de inserção no mercado de turismo a partir da tematização dos espaços. Com base em um resgate teórico conceitual são debatidas questões envolvendo a própria constituição da ideia de patrimônio no Brasil e seu uso como elemento turístico e temático. No contexto da cidade de Tiradentes, sobretudo das transformações ocorridas no centro histórico, foi possível observar, por meio de levantamentos bibliográficos, um processo conjunto envolvendo agentes diversos na busca pela produção da paisagem turística. Nesta produção a paisagem tem adquirido roupagens distintas ao longo do ano de modo a atrair o turista e criando elementos que a faz ser reconhecida no mercado de turismo.
Intermittent Wolff-Parkinson-White Syndrome Mimicking a Ventricular Tachycardia
Authors: Chang Herman Chih-Heng , Chen Chun-Lin , Lo Huey-Ming
Published: December 2023

This case report describes a patient in their 50s with a history of pneumoconiosis and chronic obstructive pulmonary disease who presented to the emergency department with sudden onset shortness of breath.
Ablation of DGKα facilitates α‐smooth muscle actin expression via the Smad and PKCδ signaling pathways during the acute phase of CCl4‐induced hepatic injury
Authors: Seino Keiko , Nakano Tomoyuki , Tanaka Toshiaki , Hozumi Yasukazu , Topham Matthew K. , Goto Kaoru , Iseki Ken
Published: December 2023

Expression of α‐smooth muscle actin (αSMA) is constitutive in vascular smooth muscle cells, but is induced in nonmuscle cells such as hepatic stellate cells (HSCs). HSCs play important roles in both physiological homeostasis and pathological response. HSC activation is characterized by αSMA expression, which is regulated by the TGFβ‐induced Smad pathway. Recently, protein kinase C (PKC) was identified to regulate αSMA expression. Diacylglycerol kinase (DGK) metabolizes a second‐messenger DG, thereby controlling components of DG‐mediated signaling, such as PKC. In the present study we aimed to investigate the putative role of DGKα in αSMA expression. Use of a cellular model indicated that the DGK inhibitor R59949 promotes αSMA expression and PKCδ phosphorylation. It also facilitates Smad2 phosphorylation after 30 min of TGFβ stimulation. Furthermore, immunocytochemical analysis revealed that DGK inhibitor pretreatment without TGFβ stimulation engenders αSMA expression in a granular pattern, whereas DGK inhibitor pretreatment plus TGFβ stimulation significantly induces αSMA incorporation in stress fibers. Through animal model experiments, we observed that DGKα‐knockout mice exhibit increased expression of αSMA in the liver after 48 h of carbon tetrachloride injection, together with enhanced phosphorylation levels of Smad2 and PKCδ. Together, these findings suggest that DGKα negatively regulates αSMA expression by acting on the Smad and PKCδ signaling pathways, which differentially regulate stress fiber incorporation and protein expression of αSMA, respectively.
Optimal model predictive fuzzy control of DC–DC convertor
Authors: Salari F. , Hasanlu M.
Published: December 2023

Nowadays, controlling industrial processes and choosing the proper method for this purpose is very important. DC–DC converters are widely used in industrial applications, such as DC–DC step‐up converters of 150 and 250 V in power drives and power supplies of portable electrical and hybrid vehicles. A predictive control algorithm is a method to deal with such complex processes. Many methods have been proposed as predictor control, leading to better and more accurate evolution with problems. This study proposes a fuzzy explicit predictive control method for adjusting the boost DC–DC converter. A fuzzy method for selecting the weights of the cost function of the predictive control algorithm of the DC–DC converter will be presented. In addition, for better evaluation and analysis, the designed controller is compared with similar methods, and the simulation results show that the controller designed on this system has had a proper performance with other methods in realizing the desired goals.
The Photoelectric Synaptic Device with Sensing‐Memory‐Computing Function Regulated by All‐Optical Pulse
Authors: Zhang Yongle , Guo Qianwen , Duan Yingfeng , Yang Feng , Feng Xue , Zheng Mingli , Guo Junmeng , Cheng Gang , Du Zuliang
Published: December 2023

The photoelectric synaptic devices with the bidirectional optical response and multilevel nonvolatile all‐optical pulse control are the basis for constructing the sensing‐memory‐computing hardware network. However, the current all‐optical‐pulse‐regulated photoelectric synaptic devices cannot realize the bidirectional and multistage nonvolatile regulation of photocurrent responsivity under the detection light excitation. Here, p‐Si/n‐ZnO heterojunction synaptic devices are constructed, and the bidirectional, nonvolatile control of the synaptic device under visible light excitation is realized with up to 60 states of photocurrent responsivity by ultraviolet (UV) and near‐infrared (NIR) irradiation. Based on the performance of the synaptic device, the artificial feedback network can be built to realize the classification and recognition of colored handwritten digits. The recognition accuracy for optical handwritten digits at 415, 530, and 970 nm is 78.1 ± 1.2%, 79.4 ± 1.9% and 79.0 ± 1.6%, respectively. Additionally, the 3 × 3 convolution kernel constructed by the synaptic device can realize image‐processing functions like mean filtering, Gaussian filtering, and edge enhancement. The development of sensing‐storage‐computing all‐optical control artificial vision hardware networks can be greatly aided by the new approach to bidirectional and multistage nonvolatile all‐optical pulse regulation of photoelectric synaptic devices that is proposed in this paper.
Deep‐Learning‐Assisted Neck Motion Monitoring System Self‐Powered Through Biodegradable Triboelectric Sensors
Authors: Sun Fengxin , Zhu Yongsheng , Jia Changjun , Wen Yuzhang , Zhang Yanhong , Chu Liang , Zhao Tianming , Liu Bing , Mao Yupeng
Published: December 2023

In the new era of artificial intelligence (AI) and the Internet of Things (IoT), big data collection and analysis for intelligent sports are of great importance in monitoring human health. Herein, naturally, biodegradable triboelectric nanogenerators (NB‐TENGs) are developed based on low‐cost, recyclable, and environmentally friendly corn bracts, which are further applied in neck motion recognition. Three NB‐TENGs are integrated into an elastic collar to create a neck‐condition monitoring triboelectric sensor (NCM‐TS). An intelligent behavioral monitoring system is achieved by combining NCM‐TS with a deep learning model, which allows the recognition of four types of neck motion with an average accuracy of 94%. The developed neck motion monitoring sensor has broad potential applications in sports health monitoring, rehabilitation training, and healthcare.