bluuebunny/crossref_metadata_2025 huggingface dataset:
Ethymological dictionary of the Russian language — heritage of the Russian and world linguistics (pro-Fasmer)
Authors:   Uzbek State University of World Languages, Dzhusupov Mahabet
Published: September 2022

The article deals with the problem of culture of scientific discussion on the material of antifasmer content of V.L. Pisanov’s article in the “Literaturnaya gazeta” “The mine, which was planted by Max Fasmer”. The author of the article attributes antirussism, adherence to fascist ideology, extensive to Indo-European bias of M. Fasmer in the process of creating four-volume Ethymological dictionary of the Russian language. All topics above do not content in the Dictionary. Compliance with a culture of the scientific discussion is the basis of a scientific development. It is observed in all works, including in V.V. Ivanov’s, O.O. Suleymenov’s investigations of the ancient origin of a word and script. The Ethymological dictionary of the Russian language is the unique work, which was created by the great scientist, humanitarian scientist, who stands on a fundamental platform of objectivity and verity of science. M. Fasmer considers a science as supranational, supraindividual, supraideological occurrence of an attitude reality and its relation to humanity on the whole. M. Fasmer appeals to living and dead languages: Slavic, German, Roman, Turkic, Latin, Greek etc. to define an ethymon of a word. Ethymon of a word could be found not only in the Russian or another Slavic languages, but also in languages of other families (Indo-European, Ural-Altai etc.). Such objective scientific analysis, scientific search of M. Fasmer is necessity for carry outing an ethymological investigavtion, thus mutual action, mutual influence of languages and cultures rest indelible mark from the ancient times in modern national languages and cultures. Ethymological dictionary of the Russian language of M. Fasmer is a model for creating ethymological dictionaries on the material of other languages. Antifamerity of V.L. Pisanov in scientific terms is antiobjective, antievidential, anticultural, antihumane statement. M. Fasmer and his four-volume Ethymological dictionary of the Russian language is pro-Fasmer, pro-ethymology, pro-scientifity, pro-humanity.
Typology of composition in Village prose of 20th century
Authors:   Gorky Institute of World Literature of the Russian Academy of Sciences, Bolshakova Alla Yu.
Published: September 2022

The purpose of this article is to give an idea of the typology of compositional forms in Russian literature of the last century on the example of the leading literary trend of the second half of the twentieth century, the Village prose, in which compositional organization was of priority importance in comparison with the plot. Understanding the composition as the internal structure of the work, the author of the article aims to prove its importance in the organization of the artistic whole. The tasks of the author of this work include consideration of such key types of composition for the Village prose as circular, associative, temporal (retrospective, anachronistic) ones, composition of off-plot elements, etc. This problem is solved on the basis of the study of the works by V.P. Astafyev, V.G. Rasputin, A.Ya. Yashin, B.P. Ekimov, etc. The significance of the sound image in the compositional organization of the work as associated with the traditions of the song culture of Russia has been considered separately. A special attention, based on the concept of B.A. Uspensky, is paid to the problem of points of view in narrative composition, the dialectic of which provides in the Village prose the narrative organization of the composition on the principle of changing points of view: from the highest points of view, coming from Russian cosmism, to the immanent current reality. As a result of this study, the conclusion has been made about the diversity and significant content of compositional forms that perform not a formal, but an essential role in the implementation of the ideological and artistic concepts of writers in the Village prose.
The paradigm of femininity in the prose of Augusta Damanskaya
Authors:   Pushkin Leningrad State University, Demidova Olga R.
Published: September 2022

The article treats the invariant female characters’ paradigm presented in short stories written by the forgotten Russian first wave émigré writer A. Damanskaya and included in her first four collections published before emigration, in the 1900–1910s. Relying on gender methodology, the author of the article carries out a detailed textual analysis singling out two basic structural oppositions of the stories, i.e., the “male female” and the “traditional heroine — “new” heroine” ones. The analysis makes it possible to define the heroines’ characteristic features as well as the main plot lines and collisions as the frame for their comparison and juxtaposition. Besides, the author treats Damasnkaya’s prose as part of Russian literature of the time, comparing a number of themes and plot collisions present in both Damanskaya’s short stories and in male prose of the period to highlight Damanskaya’s original way of treating well-known plots and characters.
“As if we have exchanged our fates with you”: artistic dialogue between N.S. Gumilev and S.M. Gorodetsky
Authors:   Gorky Institute of World Literature of the Russian Academy of Sciences, Filatov Anton V. ,   Lomonosov Moscow State University
Published: September 2022

The article examines the poems of N.S. Gumilyov and S.M. Gorodetsky, forming an artistic dialogue that reflects the development of their literary relations during the existence of the literary association “The Guild of Poets” and Acmeism founded by them. It is noted that most of this dialogue is presented on the pages of the literary magazine “Hyperborean” (1912–1913), which was the printing organ of “The Guild”. The aim of the work is to show how the theoretical provisions of Acmeism are embodied in the works of its leaders dedicated to each other. The unifying idea of Gorodetsky’s poems “Since in Flame and Smoke…” and Gumilyov’s “To Departing One” is the idea of exchanging the fates. It is intended to demonstrate to demonstrate the dialectical unity of two syndics’ aesthetic views, in a situation where mutual influence transforms the personality and creativity of both poets. It is shown for the first time that the intensification of contradictions between Acmeists led to the destruction of this dialogue, which at the textual level was reflected in the change of the named poems when they were re-published in a book edition. It is concluded that there is a significant difference between the magazine and book versions of the works, which arises both by changing the text and by placing it in a new context. As a result, the semantic connections of the poem with its original environment are leveled. Since the book of poems, as a rule, publishes the final version of the work, this allows the author to exclude its original version from the literary process.
Semantic focuses of a text. Communicative sense
Authors:   nstitute of Linguistics of the Russian Academy of Sciences, Nikitina Elena S.
Published: September 2022

The communicative paradigm, which supplemented the activity paradigm in the 20th century, allowed the text to rise to the status of the subject, replacing in the written form the communicative partner, and thus elevating understanding to the rank of an independent process of mental activity with its product. In the communicative paradigm, the Subject (Speaker) is opposed to the other Subject (Destination), not the Object. The place of one of the Subjects can be taken by the text as a sociocultural formation, the keeper of cultural and historical memory and the accumulator of human senses. The subjectivity of the text is the result of the consolidation of writing in culture. The semantic space of a text as a sign is three-dimensional. Its coordinates are located on the axes of the speech event: beingness, thinkability and communicability of the text. In the terms of rhetoric — ethos, logos and pathos. These spaces gather the focus of the senses of the text. Any text includes the senses of being, typological and communicative. As a communicative subject, the text is always addressed to someone. It does not simply recreate being, but also addresses it to others. In other words, the text contains a model of a potential reader to whom the content of the text is addressed, as it requires a certain encyclopedic competence for understanding. The relationship with this reader creates a possible focus of text sense: a certain language code, a certain literary style, certain signs of specialization, and the role functions of the text itself in relation to readers. The addressed sense is a communicative sense, paralogical in its linguistic characteristics, which gathers like-minded people around itself, who understand each other in the culture of interlocutors.
Textual notes to D.S. Merezhkovsky “Non-War Diary. 1914–1916” (based on archival materials from RO IRLI)
Authors:   Lomonosov Moscow State University, Kholikov Alexey A. ,   Gorky Institute of World Literature of the Russian Academy of Sciences
Published: September 2022

The author of the article for the first time produces a detailed textual analysis of the collection of D.S. Merezhkovsky “Non-War Diary. 1914–1916” (1917), relying on archival materials from the RO IRLI (Pushkin House). For most of the articles that made up this book, various documents have been preserved: preparatory notes and extracts, draft and white manuscripts, typescripts, newspaper clippings. Their value is determined not only by the tasks of textual criticism, but also by the history of literature and interpretive poetics. As a result, it became possible to outline in more detail the pre-press history of a number of articles and fill in the gaps in our understanding of them. On specific examples, we were able to characterize the logic of finalizing texts by a writer (from a manuscript to a newspaper publication and then to a collection); clarify ideas on the problem of distinguishing between censored / editorial and author’s excluded fragments in Merezhkovsky’s articles; expand knowledge of the sources he used. Documentary evidence of the author’s direct participation in the compositional organization of the book is given, and the dynamics of structural solutions is revealed. Thanks to additional facts, we supported the conclusion about the creative nature of the changes introduced in the preparation of the “Non-War Diary. 1914–1916” taking into account the changing socio-political background and “fluctuations” in the views of Merezhkovsky. Finally, the analytical review of archival materials from the RO IRLI helped expand the historical and literary context of Merezhkovsky’s speeches and reveal the writer’s hidden polemics with his contemporaries.
O espelho do mundo: Juquery, a história de um asilo
Authors: Cunha Maria Clementina Pereira
Published: September 2022

Este livro, publicado pela primeira vez em 1986, descreve e analisa o surgimento da medicina mental no Brasil nas últimas décadas do século XIX e a implantação de um hospício modelar, segundo suas regras, na cidade de São Paulo. Para tanto, examina os postulados adotados pelo alienismo e suas prescrições, o próprio funcionamento da instituição nomeada como Hospício do Juquery bem como seus significados históricos na conjuntura do pós-abolição e da mudança de regime político. A análise opera também com a ótica dos homens e das mulheres internados no Juquery, buscando nos prontuários o embate entre o ponto de vista dos médicos e dos pacientes. Finalmente, trata do momento em que, diante de uma visão crescentemente autoritária, o hospício abandona o “otimismo terapêutico” de seus fundadores para se tornar um depósito de seres humanos sem saída e sem esperança.
Capacidades endógenas, trajetórias tecnológicas e planos corporativos
Authors: Monteiro Maurilio
Published: September 2022

O artigo analisa o Plano Amazônia Sustentável e o Macrozoneamento Ecológico-Econômico da Amazônia Legal, estratégias de desenvolvimento que priorizam a interação entre inovação e arranjos institucionais territoriais. A aplicação de técnicas de análise espacial explicitou gaps entre os padrões espaciais subnacionais de interação entre agentes, capacidades e fontes de inovação sustentadas pela racionalidade industrialista, evidenciando limites na pretensão estratégica de impulsar, em territórios amazônicos, arranjos institucionais que embasem formas mais qualificadas de utilização dos recursos naturais. Demonstra-se aqui a desconsideração de conexões extrarregionais que influem na determinação do potencial endógeno de inovação dos territórios; além disso, trajetórias tecnológicas e padrões de reprodução de agentes relevantes não foram devidamente aquilatados na construção das estratégias. Essas incongruências fragilizam, sobremaneira, o dimensionamento, a abrangência, a extensão e as reorientações de arranjos institucionais necessárias para incorporar ciência, tecnologia e inovação a dinâmicas produtivas capazes de conformar um novo modelo de desenvolvimento na Amazônia brasileira.
Formação em pedagogia na América Latina
Authors: Severo José Leonardo Rolim de Lima , Pimenta Selma Garrido
Published: September 2022

Este trabalho relata uma pesquisa cujo objetivo consistiu em analisar a condição disciplinar e a formação em Pedagogia na Argentina, no Brasil, na Colômbia e no México, a partir do exame do processo de institucionalização de estudos pedagógicos em nível superior e das configurações formativas de cursos de Pedagogia (Colômbia, Brasil e México) e Ciências da Educação (Argentina). Tratam-se de cursos com finalidades curriculares equiparáveis por objetivarem a formação de profissionais da educação no marco mais amplo de trabalho pedagógico, sem centrarem-se exclusivamente no magistério. Os dados referentes às configurações formativas consistiram nos planos de estudos de sete cursos de 2 universidades mexicanas, 2 universidades colombianas e 3 universidades argentinas. Em se tratando do contexto brasileiro, problematizou-se o curso de Pedagogia diante das contradições das suas atuais diretrizes curriculares nacionais, homologadas em 2006. Com base nesse panorama de dados, foi possível estabelecer a crítica comparativa-reflexiva de que há um esforço acadêmico mais evidente para situar a Pedagogia como campo disciplinar na Argentina, na Colômbia e no México, especialmente como base para justificar a existência de cursos dirigidos à formação de profissionais da educação para além do magistério, inclusive com componentes curriculares específicos que englobam as bases identitárias da Pedagogia. O contexto brasileiro, por sua vez, é marcado pelo obscurecimento da discussão epistemológica que situa a Pedagogia na esfera da ciência.
The role of the dietary patterns in the cardiovascular disease risk prevention
Authors: Pelczyńska Marta , Burak Weronika , Królak Stanisław , Geppert Adrianna , Lipczyński Marcel , Grzybołowska Julia , Kociubiński Patryk
Published: September 2022

Cardiovascular diseases (CVD) are a part of a wide group of diseases, which became main threat to the life and health of the population in highly developed countries. To prevent and treat CVD, in addition to implementation of pharmacological methods, there are a number of lifestyle components, including eating habits, that significantly influence the development of these diseases. The dietary patterns strongly correlate with the risk of cardiovascular disease. Modifications of the dietary habits allow to control many parameters such as: body weight, cholesterol/triglyceride levels or blood pressure. Alternative diets are frequently used to reduce the risk of developing a CVD. The main recommended dietary patterns includes Mediterranean diet (MD), the DASH diet (Dietary Approach to Stop Hypertension) and mild variants of vegetarianism. The more controversial nutritional styles includes the ketogenic or vegan diets. Due to various assumptions as well as the mechanisms of action of each diets, an attempt of its evaluation have been made. The aim of our study is to review and analyze the available data on the impact of various nutrition models regarding to cardiovascular diseases risk prevention.
Towards Building a Naturalistic Cycling Dataset Capturing Bicycle/Car Interactions
Authors: Alazemi Fahd , Fadhloun Karim , Rakha Hesham , Mittal Archak
Published: September 2022

As machine learning and computer vision techniques and methods continue to advance, the collection of naturalistic traffic data from video feeds is becoming more and more feasible. That is especially true for the case of bicycles, for which the collection of naturalistic data is not achievable in the traditional vehicle approach. This study describes a research effort that aims to extract naturalistic cycling data from a video dataset for use in safety and mobility applications. The used videos come from a dataset collected in a previous Virginia Tech Transportation Institute study in collaboration with SPIN in which continuous video data at a non-signalized intersection on the Virginia Tech campus was recorded. The research team applied computer vision and machine learning techniques to develop a comprehensive framework for the extraction of naturalistic cycling trajectories. In total, this study resulted in the collection and classification of 619 bicycle trajectories based on their type of interactions with other road users. The results confirm the success of the proposed methodology in relation to extracting the locations, speeds, and accelerations of the bicycles at a high level of precision. Furthermore, preliminary insights into the acceleration and speed behavior of bicyclists around motorists are determined.
Facebook and Suicidal Behaviour: User Experiences of Suicide Notes, Live-streaming, Grieving and Preventive Strategies. A Scoping Review.
Authors: Shoib Sheikh , Chandradasa Miyuru , Nahidi Mahsa , Amanda Tan Weiling , Khan Sonia , Saeed Fahimeh , Swed Sarya , Mazza Marianna , Di Nicola Marco , Martinotti Giovanni , Di Giannantonio Massimo , Armiya’u Aishatu Yusha’u , De Berardis Domenico
Published: September 2022

Background: Facebook represents a new dimension for global information sharing. Suicidal behaviours and attempts are growingly reported on Facebook. This scoping review explores the various aspects of suicidal behaviours associated with Facebook, discussing the challenges and preventive measures. Methods: PubMed, Google Scholar, and Scopus were searched for related articles published in English up to October 2021, using different combinations of "Facebook" and "suicide". A group of consultant psychiatrists screened the records and read the full-text articles to extract relevant data. Results: Facebook impacts suicidal behaviours in different aspects. Announcing suicides through sharing notes or personal information, which can be helpful in prediction of suicide, and harmful since negatively affects audience. Live-streaming videos of suicide is another aspect, which questions the ability of Facebook to monitor shared contents that can negatively affect the audience. Helping bereaved families to share feelings and seek support online, commemorating the lost person by sharing their photos is another positive impact. Moreover, it can provide real-world details of everyday user behaviours, which are helpful to predict suicide risk, primarily through novel machine-learning techniques, and provide early warning and valuable help to prevent it. It can also provide a timeline of the user's activities and state of mind before suicide. Conclusions: Social media can detect suicidal tendencies, provide support for those seeking help, comfort family and friends with their grief, and provide insights via timelining the users' activities leading to their suicide. The lack of quantitative studies on evaluating preventative efforts on Facebook was one of the limitations. The creators' commitment and the users' social responsibility will be required to create a mentally healthy Facebook environment.
Effectiveness Asistensi Mengajar In Improving Quality Of Learning Through The MBKM Program
Authors: Restiningtyas Latifah Nur , Sayekti Tri , Maryani Kristiana
Published: September 2022

This research was motivated by the Merdeka Belajar Kampus Merdeka (MBKM) program. Asistensi Mengajar program is one of the innovations designed by the Indonesian Ministry of Education and Culture in 2021 to facilitate educational units, especially ECE institutions. This study aimed to determine the effectiveness of Asistensi Mengajar in Raudhatul Athfal Al-Izzah Serang-Banten. This research shows; (1) the application of the Asistensi Mengajar program, (2) the role of Asistensi Mengajar in improving the quality of learning, (3) the influence faced by the program. Using descriptive qualitative research method Miles and Huberman model. The subjects of this study were 5 teachers in grades A3, B1, B3, B6, and B7 with 5 Asistensi Mengajar students. The data were obtained through interviews, documentation, and observations which were processed for 3 months. The results of this study, are; (1) Asistensi Mengajar provides new changes for learning, (2) there is an increase in children as long as Asistensi Mengajar is involved in the learning process, (3) the impact it has is the difference in teacher parenting patterns with Teaching Assistant (TA). This research implies that teachers and Asistensi Mengajar must work together to support effective learning.

Penelitian ini dilatarbelakangi oleh program Merdeka Belajar Kampus Merdeka (MBKM). Program Asistensi Mengajar menjadi salah satu inovasi baru yang dirancang oleh kemdikbud pada tahun 2021 dalam memfasilitasi satuan pendidikan, khususnya lembaga PAUD. Tujuan Penelitian ini untuk mengetahui Efektivitas Asistensi Mengajar dalam meningkatkan kualitas pembelajaran di Raudhatul Athfal Al-Izzah Serang-Banten. Penelitian ini menunjukkan; (1) penerapan program Asistensi Mengajar terhadap peserta didik, (2) peran Asistensi Mengajar dalam meningkatkan kualitas pembelajaran, (3) pengaruh yang dihadapi program tersebut. Menggunakan metode penelitian Kualitatif deskriptif model Miles dan Huberman. Subjek penelitian ini adalah 5 guru kelas A3, B1, B3, B6, dan B7 dan 5 orang mahasiswa Asistensi Mengajar. Data didapatkan melalui hasil wawancara, dokumentasi, dan hasil observasi yang diolah selama 3 bulan. Hasil penelitian ini, adalah; (1) Asistensi Mengajar memberikan perubahan baru bagi pembelajaran, (2) terdapat peningkatan pada anak selama Asistensi Mengajar terlibat dalam proses pembelajaran, (3) dampak yang dimiliki adalah perbedaan pola asuh guru dengan Asistensi Mengajar. Penelitian ini berimplikasi pada guru dan asisten pengajar harus memiliki kerja sama untuk menunjang pembelajaran yang efektif.
Uso De Tics Y Aprendizajes En Pandemia En Un Colegio De Alto Hospicio En El Norte De Chile
Authors: Silva Fuentes Diana , Celis Parra Israel , Garcés Soto Alexandra
Published: September 2022

El presente estudio se centra en la educación remota de emergencia en tiempos de pandemia en un colegio de Alto Hospicio, donde los docentes utilizan diversas metodologías en la aplicación de sus prácticas docentes de la asignatura de ciencias para la ciudadanía. Se utilizó la metodología de carácter cualitativa con la finalidad de conocer y describir el rol docente y su descripción de los estudiantes en la modalidad remota, en los cuatro niveles educativos de primer a cuarto año medio. La muestra efectiva fueron 2 docentes y como técnica de recolección de datos se utilizó una entrevista en profundidad que fue trabajada a través de categorías. Como conclusiones se destaca la aplicación de recursos tecnológicos y las particularidades de los docentes para motivar e incentivar al alumnado.
Coincidence of Fixed Points with Mixed Monotone Property
Authors: Hashim Amal M. , Kazem Ali A.
Published: September 2022

The purpose of this paper is to introduce and prove some coupled coincidence fixed point theorems for self mappings satisfying -contractive condition with rational expressions on complete partially ordered metric spaces involving altering distance functions with mixed monotone property of the mapping. Our results improve and unify a multitude of coupled fixed point theorems and generalize some recent results in partially ordered metric space. An example is given to show the validity of our main result.
A Study of a-Si:H Absorption Edge Using Dunstan’s Model
Authors: Sahal Lana F. , Al-Numan Abdullah
Published: September 2022

The optical absorption data of Hydrogenated Amorphous Silicon was analyzed using a Dunstan model of optical absorption in amorphous semiconductors. This model introduces disorder into the band-band absorption through a linear exponential distribution of local energy gaps, and it accounts for both the Urbach and Tauc regions of the optical absorption edge.Compared to other models of similar bases, such as the O’Leary and Guerra models, it is simpler to understand mathematically and has a physical meaning. The optical absorption data of Jackson et al and Maurer et al were successfully interpreted using Dunstan’s model. Useful physical parameters are extracted especially the band to the band energy gap , which is the energy gap in the absence of disorder, that can be interpreted as the mobility gap of the material.
Fusion Reaction Study of some Selected Halo Systems
Authors: Abbas Shaimaa A. , Hussein Aeshah Ali , Obaid Sarah M. , Mohammed Noor Adil
Published: September 2022

The challenge in studying fusion reaction when the projectile is neutron or proton rich halo nuclei is the coupling mechanism between the elastic and the breakup channel, therefore the motivation from the present calculations is to estimate the best coupling parameter to introduce the effect of coupled-channels for the calculations of the total cross section of the fusion  , the barrier distribution of the fusion   and the average angular momentum 〈L〉 for the systems 6He+206Pb, 8B+28Si, 11Be+209Bi, 17F+208Pb, 6He+238U, 8He+197Au and 15C+232Th using quantum mechanical approach.  A quantum Coupled-Channel Calculations are performed using CC code. The predictions of quantum mechanical approach are comparable with the measured data that is available. Above and below the Coulomb barrier, comparison of theoretical calculations of quantum mechanical with the relevant measured data demonstrates good agreement.
Interrelationships between sex hormones, brain-derived neurotrophic factor, and cognitive impairment in male patients with schizophrenia and receiving chronic antipsychotic treatment
Authors: Li Jin , Xiao Wenhuan , Ye Fei , Tang Xiaowei , Jia Qiufang , Zhang Xiaobin
Published: September 2022

Background: Complex interactive effects between brain derived neurotrophic factor (BDNF) and sex hormones are known to be involved to the pathogenesis of schizophrenia (SCZ). However, the impact of these interrelationships between BDNF and sex hormones on cognitive function and clinical manifestations in chronic antipsychotic-treated male (CATM) SCZ patients have yet to be investigated. We investigated interrelationships between sex hormones, BDNF, clinical symptoms, and cognitive function, in the CATM patients with SCZ.
Methods: Serum concentrations of follicular-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), progesterone (P), testosterone (T), and prolactin (PRL) were compared between a group of 120 CATM patients with SCZ and a group of 120 healthy controls. Schizophrenia symptoms were measured by the Positive and Negative Syndrome Scale, cognition by the neuropsychological tests. The levels of BDNF and sex hormones were determined by enzyme linked immunosorbent assay (ELISA).
Results: Levels of T, PRL and LH were significantly higher in the patient group than in the healthy controls while E2 levels were significantly lower. Analysis also identified positive correlations between E2 levels and BDNF levels, and BDNF levels and the digital cancellation time, in the whole sample. we found significant correlations between PRL levels and negative symptoms score in CATM patients with SCZ.
Conclusions: This study provides the first comprehensive assessment of elevated levels of LH, PRL, and T, as well as reduced levels of E2, in CATM group when compared with controls. Another exciting finding in this study is that E2 levels and BDNF levels, along with BDNF levels and the DCT, were significantly and positively correlated in the combined subjects.
Enformer: Encoder-based sparse periodic self-attention time-series forecasting
Authors: Wang Na , Zhao Xianglian
Published: September 2022

Time-series forecasting makes reasonable prediction and planning on stock forecast, traffic flow, power consumption and extreme weather warning through the correlation characteristics of its own multi-dimensional data and time. The proposed Transformer structure in natural language processing is proved to be beneficial for establishing the global dependence between vectors, which is undoubtedly advantageous for the time prediction problem. However, the unchanged introduction of Transformer into the time-series forecasting will also bring corresponding problems, including high computing complexity, vector information redundancy. And bound by the unique processing methods of natural language processing problems, it ignores the common processing methods of time-series forecasting problems. To this end, we design a lightweight Transformer structure that breaks the cascade structure of traditional Transformer encoders-decoders, only using encoder to build the network. At the same time, the CMM (Coarse Matching Module) is proposed to construct the multi-scale output of the input sequence, so that the subsequent networks can capture the dependencies with different time granularity. The self-attention head is also redesigned, called sparse periodic attention, which pays more attention to the periodic dependence of sequence context while reducing the computational complexity. The overall change gives full play to the advantages of Transformer, making it more suitable for time series prediction. Thanks to the synergy of the above innovative work, the accuracy of the algorithm proposed in this paper is improved by 7.1% on average in the testing experiments of multiple public datasets, and the prediction time efficiency is also improved by 44.1%. It is proved that the reasonable improvement of transformer structure in time-series prediction can reduce the amount of calculation and give consideration to the accuracy at the same time.
Long-term dynamic of the jumbo squid geographic distribution in Humboldt Current System
Authors: Ibanez Christian M.
Published: September 2022

Many cephalopods are plastic in their response to environmental variability; factors such as temperature and salinity are considered to have an important role in their abundance and distribution. The jumbo squid (Dosidicus gigas) is an important ecosystem component and fishery resource of the Humboldt Current System (HCS) that shows extreme changes in its distribution and abundance. The present study reveals changes of its spatial distribution using an occurrence index built using a 57-years dataset from fishery landings. Although the index showed temporal changes, it showed no relation with temperature and its anomalies in HCS. It is necessary to consider other variability sources both intrinsic and external to understand the changes in the jumbo squid distribution. This approach could be useful to explore long-term changes in geographical distribution of marine species using catch data.
Effects of transcranial direct current stimulation (tDCS) in subjects with severe traumatic brain injury in the subacute phase: Study protocol for a triple-blind randomized controlled clinical trial.
Authors: Cordeiro Barbara Naeme de Lima , Kuster Elizângela , Thibaut Aurore , Nascimento Lucas Rodrigues , Gonçalves Jessica Vaz , Arêas Guilherme Peixoto Tinoco , Paiva Wellingson Silva , Arêas Fernando Zanela da Silva
Published: September 2022

Background: Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique tested in several diseases, including traumatic brain injury (TBI). Anodic and cathodic tDCS are typically used to increase and decrease excitability, respectively, and depending on mounting and stimulation parameters, tDCS can target different brain networks. This study will examine the immediate and late effects of tDCS on cognitive function, pain, functional independence, anxiety and depression, in-hospital complications and length of stay in subjects with severe TBI in the subacute phase.
Methods: This is a randomized, two-arm, prospectively enrolled study with blinded allocation, raters, participants, and therapists blind, and intention-to-treat analysis. The study will consist of 30 subjects with severe TBI, who were discharged from the intensive care unit at least two weeks ago. Participants will be randomly allocated into an experimental group (i.e, tDCS 2mA active for 20 minutes) or a control group (i.e, tDCS sham for 20 minutes). Participants will receive sessions tDCS 5 times a week for 4 weeks, for a total of 20 sessions. Outcome measures will be collected by trained researchers at baseline (week 0), after 20 tDCS sessions, i.e at week 4 (week 4), 6 months later by telephone, and one year after treatment, also by phone.
Discussion: The search for adjuvant therapies to improve TBI outcomes is challenging, mainly due to the heterogeneity, complexity and severity of the lesions. Thus, the results of this trial may result in an important advance for neurological rehabilitation.
Trial registration: Brazilian Registry of Clinical Trials (ReBEC), RBR-37t4kc4. Registered prospectively on July 26rd , 2021
An Efficient Lexicographic Approach to Solve Multi-Objective Multi-Port Fabric Dyeing Machine Planning Problem
Authors: Demir Yunus
Published: September 2022

In this study, a decision problem for the planning of the fabric dyeing process of a factory that produces towels is discussed. Towel fabric bolts in different quantities and features belonging to different orders are dyed by batching under certain restrictions in multi-port dyeing machines. In this problem, three different objectives are aimed to be optimized: Total tardiness, total number of washes (number of sequence dependent setups), total machine fixed cost. Since the prioritization for the objectives is made clearly by the company officials, the lexicographic approach has been preferred as the solution. First, the integer programming model of the problem is created. Lexicographic optimization approach was applied for the solution of the model. Afterwards, an effective Lexicographic multi-objective Genetic Algorithm, which is an extension of the single-objective Genetic Algorithm, is proposed. The performance of both solution methods was tested with randomly generated problems. Comparative results showed that the proposed lexicographic multi-objective genetic algorithm gave effective results.
Adverse effects of montelukast in children
Authors: Al-Shamrani Abdullah saeed , Alharbi Saleh , Kobeisy Sumayyah , Alkhater Suzan , Alalkami Haleimah , Alahmadi Turki , Almutairi Aisha , Alharbi Adel , Yousef Abdullah
Published: September 2022

Montelukast is a leukotriene receptor antagonist (LTRA) commonly prescribed for asthma, allergic rhinitis and sleep-related breathing disorders. Recently, some studies have reported several adverse events, such as neuropsychiatric disorders and sleep disturbances, among children.
Objective:
To obtain more insight into the safety profile of montelukast for children with asthma, allergic rhinitis and sleep-related breathing disorders.
Method and results:
We retrospectively studied all adverse drug reactions to montelukast among 385 children 6 months or older in five tertiary centers over a two-year period. A total of 89.6% were asthmatic, 50% had allergic rhinitis and 13.6% had sleep-related breathing disorders; Singulair was the most common type of montelukast used (67.9%). This study reported a high prevalence of adverse effects among 123 patients (31.9%), predominantly in those aged 4-9 years (52.8%), followed by adolescent children (24.4%) and toddlers (22.8%). Two adverse effects were reported in 9.8% of the children, while three or more were reported in 5.5%. Sleep disturbance was the most commonadverse effect, affecting 15.1% of participants (overlap was common; 5.5% of children experienced sleep difficulties, 4.4% experienced sleep interruption and decreased sleep, and 1.82% experienced nightmares), followed by agitation (10.4%), pain (9.4%) and hyperactivity (6.8%). No serious adverse effects were reported. Eleven percent of families faced difficulties in purchasing montelukast, and only 57% of families had insurance. Misconceptions were common (9.8% reported it to be a steroid, while 30.6% believed it to be a bronchodilator). Although 81% of the families believed it was an effective and preventive medication, 5.3% stopped the drug due to concern about side effects, especially agitation (3%) and nightmares (0.6%).
Conclusion:
These data demonstrate that montelukast is effective, but the associated adverse neuropsychiatric drug reactions are more prevalent than those reported in the literature. In particular, sleep disturbance, agitation, pain and hyperactivity were observed. Pediatricians should be aware of such adverse effects. Misconceptions about montelukast are still common, and parental counseling and urgent epidemiological studies are needed to quantify the risk for management plans.
Rotator cuff tears are associated with significant psychiatric problems
Authors: KARAASLAN Fatih , AYDOĞAN Serhat , Yurdakul Emre , Yalvaç Mehmet , Dülgeroğlu Turan Cihan , Karaaslan Özgül
Published: September 2022

Questions/Purpose: In this prospective study of patients who underwent rotator cuff (RC) repair, we aimed to evaluate the pre- and post-operative rates of depression, anxiety, and sleep disturbances, investigate the impact of psychological health and sleep disturbances on the surgical outcomes, and identify the preoperative predictors for surgical outcomes.Methods: Patients who underwent RC repair after failed non-operative treatment were included in this study. All patients were evaluated using the visual analogue scale, American Shoulder and Elbow Surgeons Shoulder Score, constant score, the abbreviated World Health Organization Quality of Life questionnaire, Beck depression inventory, Beck anxiety inventory, and the Pittsburgh sleep quality index preoperatively and postoperatively at the 6-month follow up.Results: Eighty-two patients (20 males and 62 females) with a mean age of 67 years were included in this study. Depression was observed in 48% (mean score = 10.83), anxiety in 51% (mean score = 10.11), and sleep disturbance in 69% (mean score = 6.00) of patients pre-operatively.Conclusions:Shoulder function, depression, and anxiety scores significantly improved, while sleep disturbance decreased, after RC repair. RC tears are associated with significant psychiatric problems.
Evaluation of flood period effects on nutrient and gross primary productivity changes in Shadegan wetland
Authors: Azizi Fatemeh , savari ahmad , Amini Faedeh , asgari hossein mohammad , doustshenas babak
Published: September 2022

Floodplain wetlands in semi-arid regions that are subject to changes in hydrology and geomorphology during the annual flood period have measurable impacts of these ecosystems. This study aimed to investigate the effects of water level fluctuations during the flood period on the water physicochemical properties, nutrient status, sestonic chlorophyll a, and composition of the phytoplankton community of phytoplankton in Shadegan ‎wetland. The hypothesis of this study which was based on water level fluctuations during the flood period ‎is the key controlling regulator of the wetland’s physicochemical, nutrient status, phytoplankton community structure driven by its influence on the wetland’s hydrological connectivity in combination with other environmental parameters. The results showed that most environmental variables and nutrients differed significantly each season in the three different periods of ‎flood ‎for three consecutive years (2017–2019) in the Shadegan wetland. During flood season, the nutrient concentration, carbon content of the water body, and chlorophyll a conentration are significantly higher than during dry and wet seasons. There was a significant difference in the structural community of phytoplankton in flood periods. The results suggested that changes in water levels during flood periods in Shadegan wetland can directly affect the phytoplankton ‎community and gross primary productivity or indirectly via changes in nutrient levels, hydrological ‎connectivity, and other environmental parameters. This study can present beneficial knowledge of hydrological and ecological dynamics in wetland, providing a useful reference in the management of irregular withdrawals from water resources, and increasing the cultivation lands on upstream rivers of the Shadegan Wetland.
Matrix stiffness-induced transcriptome alterations and regulatory mechanisms revealed by RNA-seq in Endothelial cells
Authors: Zhang Chao , Han XiaoMei , Xu Jin , Jiang MeiLin , Zhou Yue
Published: September 2022

Background
Changes in vascular stiffness are associated with the development and progression of many diseases, especially in cardiovascular disease. However, the effect of vascular stiffness on the endothelial cells (ECs) is not fully understood. This study focused on the transcriptional profiles of ECs cultured on the matrices with different stiffness (1kPa and 40kPa, respectively) to broaden the knowledge of mechanotransduction.
Methods
We first prepared hydrogel materials with different stiffness to simulate the vascular stiffness in normal and pathological states, respectively. RNA sequencing was then conducted on endothelial cells cultured on matrix for 24 hours. Gene Ontology (GO) enrichment analysis, Kyoto Encyclopedia for Genes and Genomes (KEGG) pathway analysis, protein–protein interaction (PPI) network analysis and transcription factors (TFs) and their target genes analysis were performed on differentially expressed genes (DEGs). qRT-PCR was finally utilized to validate the hub dysregulated genes.
Results
We obtained 1775 differentially expressed genes (DEGs) by RNA-seq, with 450 up-regulated and 1325 down-regulated DEGs in ECs cultured on soft matrix (1kPa) compared to those cultured on stiff matrix (40kPa). According to GO and KEGG analysis, DEGs were mainly enriched in cell junctions and cell-matrix interaction related signaling pathways. In order to confirm the RNA-seq results, we performed real-time qPCR analysis on the genes of interest, including cadherin 5, F11 receptor (also known as junctional adhesion molecule-A), fibronectin 1, collagen α2(IV) chain, matrix metalloproteinase-14 and integrin α5, and found that the expression level of all these genes were down-regulated on soft matrix, suggesting that soft matrix caused by pathological conditions may directly attenuate vascular barrier function.
Conclusions
In summary, the results of RNA-Seq suggested that matrix stiffness may affect extracellular matrix (ECM) integrity, cell-ECM interactions, and cell-cell junctions. This study offers the insights about the effects of physical stimulation on cells, paving a way for vascular tissue engineering, regenerative medicine, disease modeling and therapies.
Valorization of three pecan nutshell cultivars by ultrasound assisted extraction of polyphenolic compounds and its potential free radical inhibition
Authors: Garcia-Larez Frida Lourdes , Tapia-Hernández José Agustín , Quintana David Slim Zepeda , Moreno-Vásquez María Jesús , Rodríguez-Félix Francisco , Del-Toro-Sánchez Carmen Lizette
Published: September 2022

The present study was performed to identify the effects of ultrasound assisted extraction (UAE) conditions over total phenolic content, total flavonoid content, and antioxidant activity of pecan nutshell extracts of Western, Wichita, and Mahan cultivars. The analyzed UAE conditions were extraction time, amplitude, and sample-solvent ratio. Antioxidant activity was evaluated through ABTS, DPPH, and FRAP assays. Optimal extraction conditions were used to obtain an extract for the determination of medium inhibitory concentration (IC 50 ) and FTIR analysis. Results indicate that extraction time of 25 min favored the extraction of phenolic compounds and flavonoids; in addition, extract with an extraction time of 1 min exhibits antioxidant activity by ABTS, while extraction time of 5 min presents higher DPPH and FRAP activity. The highest concentration of phenolic compounds and flavonoids was obtained with a 50% amplitude. Antioxidant activity by ABTS was higher for an extract with 80% amplitude, while extract with 30% amplitude had higher antioxidant activity by DPPH and FRAP. Sample-solvent ratio of 1/50 had the highest content of phenolic compounds while flavonoid content was higher in the extract with a 1/30 sample-solvent ratio. Sample-solvent ratio using UAE did not have an effect over antioxidant activity by ABTS and DPPH; however, antioxidant activity by FRAP was increased by UAE were a 1/30 sample-solvent ratio exhibited the highest value. FTIR spectra suggests the presence of phenolic compounds, proteins, and polysaccharides; therefore, bioactive compounds can be recovered from pecan nutshell through ultrasound assisted extraction.
Establishment of a Visualized Mouse Orthotopic Model of Nasopharyngeal Carcinoma
Authors: Chen Wei , Chen Sixia , Jiang Li , Shu Gege , Yin Yuanxiu , Quan Zhipeng , Zhou Ziyan , Shen Mingjun , Qin Yating , Yang Chaolin , SU Xuejin , Chen Weimin , Kang Min
Published: September 2022

Background
Nasopharyngeal carcinoma, one of the most common head and neck tumours, is particularly prevalent in Southeast Asia and is characterized by high rates of metastasis and recurrence. Mouse orthotopic tumour models are commonly employed in studies investigating the mechanisms underlying tumour development and progression, as well as preclinical treatment. However, mature and visualized orthotopic models of nasopharyngeal carcinoma are currently unavailable, limiting the development of treatment strategies for nasopharyngeal carcinoma. The aim of the current study is to provide a simple and reliable method for building an orthotopic model of nasopharyngeal carcinoma.
Methods
human nasopharyngeal carcinoma C666-1-luc cells, stably expressing the firefly luciferase gene, were injected subcutaneously into the right axilla of BALB/C nude mice. Four weeks later, the resulting subcutaneous tumours were cut into small blocks and grafted into the nasopharynx of immunodeficient BALB/C nude mice to induce tumour formation. Tumour growth was monitored by bioluminescence imaging and small animal magnetic resonance imaging. The histological and immunological antigen expression associated with orthotopic nasopharyngeal carcinoma were analysed by tissue section analysis and immunohistochemistry (IHC).
Results
We successfully constructed a visualized orthotopic nasopharyngeal carcinoma model. Fluorescence signal detection, micro-magnetic resonance imaging and hematoxylin and eosin staining revealed the successful growth of tumours in the nasopharynx of nude mice. Moreover, IHC analysis detected positive CK, CK5/6, P40 and P63 expression in mouse orthotopic tumours, which is consistent with the reported antigen expression in the nasopharyngeal tumours of patients.
Conclusion
We established a reproducible, visualized and less lethal orthotopic model of nasopharyngeal carcinoma, providing a platform for researching nasopharyngeal carcinoma that is more conducive to preclinical research.