bluuebunny/crossref_metadata_2025 huggingface dataset:
Aspectos éticos na extubação de pacientes na Unidade de Terapia Intensiva nos períodos de pandemia da COVID-19: Uma revisão integrativa
Authors: Marçal Morvana Oliveira , Santana Julia Vitória de Almeida , Andrade Allana Campos Seara de , Oliveira Adailson Henrique Miranda de , Campos Filho Pedro Costa
Published: March 2024

Esse artigo possui como objetivo discutir os aspectos éticos relacionados a extubação de pacientes internados na Unidade de Terapia intensiva durante a pandemia da COVID-19 e seus principais entraves técnicos: a falta de leitos e materiais disponíveis para a população com síndrome respiratória grave; a escassez de escalas objetivas para o manejo desses pacientes; os conflitos éticos da equipe multiprofissional na tomada de decisão sobre quem e quando deve-se participar do desmame de ventilação mecânica. Para tanto, foi realizada uma revisão integrativa de estudos agrupados em três grandes categorias: falta de recursos no período pandêmico; aspectos éticos no manejo de pacientes graves em UTI e entraves morais no momento da extubação. Os resultados desta revisão evidenciaram que a escassez de recursos na época da pandemia da COVID -19 reflete em conflitos éticos no contexto da unidade de terapia intensiva, no direcionamento dos materiais disponíveis sendo de extrema relevância para o planejamento das ações direcionadas ao processo de extubação centrado no cuidado humanizado ao paciente visando alcançar resultados efetivos.
Profissionais médicos negros no Brasil: obstáculos e desafios
Authors: Oliveira Évelin Santos
Published: March 2024

O período escravocrata teve influência na estrutura social no Brasil. Pós-abolição os negros não tiveram nenhum plano de ação para inserção no mercado de trabalho. O difícil acesso à educação foi crucial para que os negros permanecessem sem muitas oportunidades de mobilidade educacional e social. Aos profissionais da área da saúde ainda se depara com o racismo institucional. Questiona-se, portanto, onde estão os profissionais médicos negros no Brasil? O objetivo do estudo foi discutir sobre as dificuldades enfrentadas pelos profissionais médicos negros e identificar ações mitigadoras do problema enfrentado no trabalho. Para fundamentar a discussão, apresentam-se debates teóricos e perspectivas de mudanças para o problema do racismo enfrentando pelos negros na medicina no Brasil. A invisibilidade destes profissionais é um dos pontos retratados, bem como a falta de estrutura no ambiente familiar e acadêmico. O racismo enfrentado é discutido como um dos pontos que fragilizam o indivíduo no campo profissional e na graduação, influenciando inclusive na autoestima do negro que se dispõe a atuar na área médica. Algumas ações vêm sendo idealizadas a fim de deixar mais próximo os médicos negros e seus pacientes, como o desenvolvimento de plataformas voltadas para o acesso de pacientes a profissionais médicos negros e especialistas voltados para doenças de maior ocorrência na assistência integral à saúde negra. São necessárias políticas públicas capazes de criar condições igualitárias na formação do profissional médico, com acesso ao ensino de qualidade e a luta dos professores e gestores quanto ao racismo reproduzido no ambiente escolar.
Violência contra a mulher e a responsabilidade médica: uma revisão integrativa
Authors: Miranda Luiza Vitória Evangelista de , Moura Rebeca Santos Saraiva de , Buchler Marina Lisa de Deus Santos , Oliveira Adailson Henrique Miranda de
Published: March 2024

A presente pesquisa busca fazer uma análise em relação à violência contra a mulher, que é considerada um problema de saúde pública, com alta prevalência no Brasil. Nessa temática, o médico tem um papel fundamental no acolhimento com resposta positiva capaz de minorar danos e sofrimentos às mulheres. A violência consiste em atitudes de empregar força física ou intimidação moral, podendo gerar abalo psicológico, físico e sexual à mulher. No Brasil, foi instituída a Lei número 10.778 em 24 de novembro de 2003, que estabelece a notificação compulsória em casos de violência contra a mulher que seja atendida em serviços de saúde públicos ou privados. A notificação compulsória tem grande importância no que se refere à oferta de dados à vigilância epidemiológica para promoção e prevenção da saúde, sendo obrigatoriedade do médico. O objetivo da pesquisa foi alertar aos médicos a importância da notificação compulsória e da responsabilidade em casos de violência contra a mulher. Assim, foram realizadas análises quanto à legislação e estudos experimentais e não experimentais.
POLÍTICAS PÚBLICAS EM EDUCAÇÃO: Sobre Educandos e Aprendizagens Simpósio de Educação, 9: 30 ago/1 set 2023
Authors: Luiz Ana Carolina Fábrega , Fernandes Andreia Gasparino , Hirosse Ariane Rodrigues de Lima , Bassetto Camila Fernanda , Cardoso Diego Alvim , Ursini Driely Turi , Lopes Gabriel , Braga Filho Hélio , Silva Hilda Maria Gonçalves da , Pousa Jonatan , Guerra José Alfredo de Pádua , Oliveira Júlia Paz , Freitas Letícia Lopes de , Freitas Lucas Morais de , Piana Maria Cristina , Silva Matheus Felipe , Sataka Mayara Mayumi , Leal Murilo Cordero , Scapim Murilo Henrique De Oliveira , Carvalho Neto Silvio , Souza Tatiana Noronha de , Thomazini Taysa Mara
Published: March 2024

Há dezoito anos, docentes do Uni-FACEF e da Unesp/Franca realizam o
Simpósio de Educação. Há doze anos, o Encontro Internacional de Políticas
Públicas em Educação. Alguns membros permanecem fixos, outros passam. Mas a
certeza, para todos, é de que a pesquisa em educação, nas várias áreas, propicia,
aos participantes, um domínio de objetos e metodologias que, seguramente,
refletem na prática cotidiana do ensino básico ou superior. Assim, reflexões que
subsidiam ações. O encontro da universidade com a educação básica.
Seja por meio de revisões bibliográficas, estudos com resultados finalizados
(ou não), debates em comunicações coordenadas ou quaisquer outras estratégias
de socialização, as investigações apresentadas, nos eventos, ganharam robustez,
presentificaram-se e foram criticadas, para alçar o auge do desvelamento do
conhecimento.
No e-book, o leitor se encontra com temáticas que envolvem a escola em
políticas públicas, desenvolvimento social e aprendizagens, temáticas relevantes
para o contexto contemporâneo, na formação inicial e formação continuada de
diversos profissionais da educação. E, nessa seara, mais do que nunca, ficam
evidentes o intercâmbio dialético com estudos e teorias das várias áreas do
conhecimento em práticas sociais que vão se estabelecendo no cotidiano escolar.
Foca-se na discussão sobre o indivíduo, seja a criança ou o adolescente, e
também em discussões sobre gênero, tecnologia e economia. Por isso, uma
abordagem interdisciplinar na análise de políticas públicas e sistemas sociais. Os
estudos imergem nas concepções teóricas clássicas e acadêmicas das políticas
públicas, passam pelas análises e avaliações de cada fase dessas políticas.
Asseguram as estratégias metodológicas que trazem rigor às discussões e aos
resultados.
No movimento, é preciso acolher a escola como vida. Assim, trazer objetos
constituídos no contexto escolar e dar-lhes um tratamento metodológico científico é
propiciar respostas mais assertivas para o momento social. Dessa forma, cada olhar
sobre a escola faz ter a certeza de que a interação entre ensino, pesquisa e também
extensão auxiliam na constituição da identidade do indivíduo, do tempo e do espaço
atual.
Em cada investigação, muita riqueza de crítica e reflexão. Muito a aprender
com cada leitura.
Cancellation of a Certificate of Ownership Based on a District Court Decision in Tanah Datar District
Authors: Aretra Intan Mariska , Nurdin Zefrizal , Rosari Anton
Published: March 2024

The problem formulations in this research are: the reason why the plaintiff did not submit a request for annulment to the BPN, the process of canceling a land title certificate based on a district court decision in Tanah Datar Regency, the status of the sale and purchase of land objects whose certificates are not valid but have not been canceled by the BPN, This research uses normative-empirical juridical methods. The reasons why the plaintiff did not submit an application for cancellation to the BPN were due to the plaintiff's ignorance of the cancellation procedure, physical control and certificates that were still controlled by the defendant, the length of the physical execution process due to resistance and the many requirements for submitting a cancellation to the BPN. 2. The process of canceling a certificate based on a court decision in Tanah Datar District begins with a request from an interested parties and then the file will be analyzed by the Land Office and then sent to the Regional Office, where the Regional Office will issue a decree of cancellation. 3.With the transfer of land rights by a person who is not the actual owner of the transferred land, his actions have clearly violated the principles that apply to land registration activities, namely the Nemo Plus Juris Principle and also the provisions of Article 1320 of the Civil Code, namely a lawful cause. Because the point of a lawful cause is violated, the agreement made by the parties becomes null and void.
Hazard Identification and Potential Risk Analysis of Toxic Metals in Redbelly Tilapia (Coptodon zillii) Consumed and Surface Water from the Niger Delta Estuary
Authors: Davies Ibienebo Chris , Amaewhule Evelyn , Nkeeh Dumbari
Published: March 2024

Anthropogenic activities have caused toxic metals to escalate, polluting rivers, and accumulating in water, sediments, and fish. This harms aquatic ecosystems and has enduring impacts on humans and aquatic life. The study aimed to assess the accumulation of heavy metals (Pb, Cr, Cu, Fe, Ni, Cd, and Zn) in Redbelly tilapia (Coptodon zillii) and water obtained from three sampling stations along Atuka Creek which is a crude oil-contaminated site in a southern creek in Nigeria. The investigation further intends to evaluate potential health risks linked to the consumption of C. zillii and to analyze the pollution and productivity levels of the corresponding aquatic ecosystem. The results show significant variations in heavy metal concentrations across stations, with Station 1 exhibiting the highest contamination levels attributed to its proximity to pollution sources. The fish from Station 1 revealed elevated levels of contamination, surpassing recommended limits for Pb, Fe, Ni, and Zn. Calculations of chronic daily intake (CDI) values indicate potential health risks for both adults and children, particularly in Stations 1 and 2. The hazard quotient (HQ) and hazard index (HI) values surpassed safe limits in these stations, suggesting non-carcinogenic health risks linked to fish consumption and swimming. Moreover, lifetime cancer risk (ILCR and TLCR) assessments revealed an augmented risk of cancer, especially in Stations 1 and 2. These findings emphasize the need for stern pollution control measures, regulations, and remediation strategies to mitigate heavy metal contamination, ensure water quality, and safeguard public health in southern Nigerian communities.
Pre-study of the evaluation of ecological sessile succession and their relationship with bacteria on concrete artificial reef material
Authors: Gül Benal , Unsal Tuba
Published: March 2024

Artificial reefs are human-made structures built for promoting marine life. Long-term monitoring and research regarding the use of artificial reefs in terms of ecological and economic perspective is essential. In this study, the ecological succession and their relationship with bacteria on concrete artificial reef material was investigated. Heybeliada artificial reef site was selected as sampling area. After three years period, the visual examination of ecological succession and sessile marine bacteria count were performed on the concrete artificial reef material. All the results showed that the strength of the artificial reef material is also affected by the biofilm layer and the creatures in the microecosystem. Therefore, monitoring studies should be carried out to determine the service life of artificial reef materials as well as to reveal the existence of the ecosystem formed and developing in these areas qualitatively and quantitatively.
Отзывчивость сортов и линий озимой мягкой пшеницы немчиновской селекции на внесение азотных удобрений в условиях Московской области
Authors: Сандухадзе Баграт Исменович , Савинов Евгений Владимирович , Мамедов Рамин Закирович , Крахмалёва Мария Сергеевна , Бугрова Валентина Васильевна
Published: March 2024

Оценена эффективность применения дробных подкормок азотными удобрениями на сорта и новые перспективные линии озимой мягкой пшеницы немчиновской селекции, сгруппированных по высоте. Изучали сорта Московская 39, Московская 56, перспективные линии Московская 28, Московская 31, Васильевна и Эритроспермум 606/19. Экспериментальные данные продемонстрировали положительное воздействие внесения азота в почву на ряд ключевых характеристик. По мере возрастания дозы азота увеличились урожайность, число стеблей на 1 м2, масса зерна с колоса, число зерен в колосе и масса 1000 зерен. Наиболее урожайными оказались линии 2-й группы: Московская 28, Московская 31, Васильевна, проходящие Государственное сортоиспытание. Наибольший коэффициент энергетической эффективности отмечен при дозах: N60 кг д.в. — у линии Эритроспермум 606/19; N120 — у линии Московская 31; N180 — у линий Московская 31 и Васильевна; N240 — у линии Васильевна. Среди перспективных линий выделяются Васильевна с высокой урожайностью (15,37 т/га) при использовании дозы N240 и короткостебельная линия Эритроспермум 606/19, высотой 65 – 70 см, обеспечивающая высокую урожайность и максимальную устойчивость к полеганию (9 баллов).
The Academic Effects of Moving to Middle School on Students With Disabilities Relative to Their General Education Peers
Authors: O’Hagan Kaitlyn G. , Stiefel Leanna , Schwartz Amy Ellen
Published: March 2024

Middle school transitions are increasingly required, despite documented negative effects on general education students (GENs). We explore if and how the move to middle school differentially affects students with disabilities (SWDs), a large and low-performing group. Using an instrumental variables strategy and New York City (NYC) data on nine student cohorts, we find the middle school transition causes a 0.29 SD decline in SWD math performance, a 0.16 SD decline in English language-arts (ELA) performance, and a one percentage point increase in grade retention. Accounting for potential mediators (e.g., peer cohort stability) does not substantially explain estimated effects on SWD performance. However, the middle school transition has similarly large negative effects on GENs, suggesting the need to ease this transition for all students.
Feasibility, Clinical Efficacy, and Maternal Outcomes of a Remote Exercise Program in Pregnant Women with Obesity: The GROB Randomized Control Pilot Study
Authors: Bernardo Diana , Bobadilla-Agouborde Carolina , Festas Clarinda , Carvalho Carlos , Pugliesi Abdalla Pedro , Amezcua-Prieto Carmen , Naia-Entonado Zeltia , Carvalho Mesquita Cristina , Mota Jorge , Clara Santos Paula
Published: March 2024

Background: Obesity is common in women of reproductive age and increases the risk during pregnancy. Exercising during this period reduces health complications. Home e-health programs are effective in overcoming exercise barriers as pregnant women use technology and the internet for health information. Methods: A single-blind randomized controlled feasibility study with pregnant women with obesity (body mass index [BMI] ≥30 kg/m2) was conducted in the University Hospital Center of São João between January and April 2023. Pregnant women were randomized to a control group with standard care and to an experimental group with 8-week remote exercise program using a Phoenix® biofeedback device. Feasibility outcome measures were recruitment rate (≥35%), loss to follow-up (≤15%), and program fidelity (≥1 session/week). Secondary outcomes were evaluated through Pregnancy Physical Activity Questionnaire, Oswestry Index on Disability, and weight assessments at baseline and at the end of the program. Results: Of the 63 eligible participants, 24 (38.1%) were successfully randomized and completed the baseline assessment. Of these, 3 (4.8%) from experimental group did not perform the initial onboarding. The control group had 8.3% of follow-up losses and for the experimental group there were no follow-up losses. Program fidelity (mean ≥1 session/week) was fulfilled by 66.7% of successfully randomized participants. Regarding secondary outcomes assessed between baseline and the 8th week, experimental group compared to control group had higher levels of physical activity for sports activities, a lower level of inactivity, and lower disability rates caused by low back pain. Conclusions: Based on the recruitment rate, losses to follow-up, and fidelity rate, the GROB (obesity in pregnancy) study was deemed feasible and worthy of consideration for a larger study. Moreover, the GROB study has the potential to improve maternal outcomes by reducing sedentarism and disability caused by low back pain. Clinical Trial Registration: The study has been registered on https://classic.clinicaltrials.gov/ (registration number: NCT05331586).
The Prognostic and Immune Significance of BZW2 in Pan-Cancer and its Relationship with Proliferation and Apoptosis of Cervical Cancer
Authors: Li Chaolin , Li Qin , Li Li , Sun Siyu , Lei Xun
Published: March 2024

Background: Basic leucine zipper and W2 domains 2 (BZW2), a member of the basic domain leucine zipper superfamily of transcription factors, has been implicated in the development and progression of various cancers. However, the precise biological role of BZW2 in pan-cancer datasets remains to be explored. This study aimed to assess the prognostic significance of BZW2 and its immune-related signatures in various tumors. Methods: Our study investigated the expression, epigenetic modifications, and clinical prognostic relevance of BZW2 using multi-omics data in different cancer types. Additionally, the immunological characteristics, tumor stemness, drug sensitivity, and correlation of BZW2 with immunotherapy response were explored. Finally, in vitro experiments were conducted to assess the impact of BZW2 knockdown on Hela cells, a cell line derived from cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC). Results: BZW2 exhibited elevated expression levels in various tumor tissues and significantly impacted the prognosis of different cancer types. BZW2 emerged as an independent prognostic factor in CESC. We found that copy number amplification and methylation levels of BZW2 were associated with its mRNA expression. Immunological analyses revealed that BZW2 shapes a non-inflamed immunosuppressive tumor microenvironment across multiple cancers. Furthermore, our cell experiments demonstrated that BZW2 knockdown reduced proliferation, migration, and apoptosis activities in CESC cells. Conclusions: BZW2 promotes cancer progression by shaping a non-inflamed immunosuppressive tumor microenvironment. Additionally, BZW2 was shown to significantly influence the proliferation, migration, and apoptosis of CESC cells.
Prognostic Model Associated with Necroptosis in Colorectal Cancer based on Transcriptomic Analysis and Experimental Validation
Authors: Huang Yuying , Li Licheng , Kang Zhongmin , Luo Huali , Lin Xiaojing , Zhao Shu , Zhang Qizhu , Li Qinshan , Liu Honglin , Li Mengxing
Published: March 2024

Purpose: Numerous studies have emphasised the importance of necroptosis in the malignant progression of colorectal cancer (CRC). However, whether necroptosis-related genes (NRGs) can be used to predict the prognosis of CRC remains to be revealed. Methods: Patients with CRC were divided into two clusters based on the expression of NRGs, and prognosis was compared between the two clusters. A prognostic model was established based on NRGs, and its predictive efficiency was validated using Kaplan-Meier (K-M) curves, receiver operating characteristic (ROC) curves and a nomogram. Immune infiltration, single-cell and drug sensitivity analyses were used to examine the effects of NRGs on the prognosis of CRC. Results: The prognostic model served as a valid and independent predictor of CRC prognosis. Immune infiltration and single-cell analyses revealed that the unique immune microenvironment of CRC was regulated by NRGs. Drug sensitivity analysis showed that patients in the high- and low-risk groups were sensitive to different drugs. In addition, H2BC18 was found to play an important role in regulating the malignant progression of CRC. Conclusion: This study provides novel insights into precision immunotherapy based on NRGs in CRC. The NRG-based prognostic model may help to identify targeted drugs and develop more effective and individualised treatment strategies for patients with CRC.
The Molecular Mechanisms behind Advanced Breast Cancer Metabolism: Warburg Effect, OXPHOS, and Calcium
Authors: Mitaishvili Erna , Feinsod Hanna , David Zachary , Shpigel Jessica , Fernandez Chelsea , Sauane Moira , de la Parra Columba
Published: March 2024

Altered metabolism represents a fundamental difference between cancer cells and normal cells. Cancer cells have a unique ability to reprogram their metabolism by deviating their reliance from primarily oxidative phosphorylation (OXPHOS) to glycolysis, in order to support their survival. This metabolic phenotype is referred to as the “Warburg effect” and is associated with an increase in glucose uptake, and a diversion of glycolytic intermediates to alternative pathways that support anabolic processes. These processes include synthesis of nucleic acids, lipids, and proteins, necessary for the rapidly dividing cancer cells, sustaining their growth, proliferation, and capacity for successful metastasis. Triple-negative breast cancer (TNBC) is one of the most aggressive subtypes of breast cancer, with the poorest patient outcome due to its high rate of metastasis. TNBC is characterized by elevated glycolysis and in certain instances, low OXPHOS. This metabolic dysregulation is linked to chemotherapeutic resistance in TNBC research models and patient samples. There is more than a single mechanism by which this metabolic switch occurs and here, we review the current knowledge of relevant molecular mechanisms involved in advanced breast cancer metabolism, focusing on TNBC. These mechanisms include the Warburg effect, glycolytic adaptations, microRNA regulation, mitochondrial involvement, mitochondrial calcium signaling, and a more recent player in metabolic regulation, JAK/STAT signaling. In addition, we explore some of the drugs and compounds targeting cancer metabolic reprogramming. Research on these mechanisms is highly promising and could ultimately offer new opportunities for the development of innovative therapies to treat advanced breast cancer characterized by dysregulated metabolism.
Impact of Toll-Like Receptors (TLRs) and TLR Signaling Proteins in Trigeminal Ganglia Impairing Herpes Simplex Virus 1 (HSV-1) Progression to Encephalitis: Insights from Mouse Models
Authors: Campos Marco Antônio , Zolini Guilherme de Pádua , Kroon Erna Geessien
Published: March 2024

Herpes simplex virus 1 (HSV-1) or simplexvirus humanalpha 1 is a neurotropic virus that is responsible for orofacial infections in humans. More than 70% of the world’s population may have seropositivity for HSV-1, and this virus is a leading cause of sporadic lethal encephalitis in humans. The role of toll-like receptors (TLRs) in defending against HSV-1 infection has been explored, including the consequences of lacking these receptors or other proteins in the TLR pathway. Cell and mouse models have been used to study the importance of these receptors in combating HSV-1, how they relate to the innate immune response, and how they participate in the orchestration of the adaptive immune response. Myeloid differentiation factor 88 (MyD88) is a protein involved in the downstream activation of TLRs and plays a crucial role in this signaling. Mice with functional MyD88 or TLR2 and TLR9 can survive HSV-1 infection. However, they can develop encephalitis and face a 100% mortality rate in a dose-dependent manner when MyD88 or TLR2 plus TLR9 proteins are non-functional. In TLR2/9 knockout mice, an increase in chemokines and decreases in nitric oxide (NO), interferon (IFN) gamma, and interleukin 1 (IL-1) levels in the trigeminal ganglia (TG) have been correlated with mortality.
Genetic Contributions to Recovery following Brain Trauma: A Narrative Review
Authors: Lakshmipathy Deepak , Rangarajan Shreya , Barreau Ariana , Lu Jeffrey , Kleinberg Giona , Lucke-Wold Brandon
Published: March 2024

Traumatic brain injury (TBI) is a frequently encountered form of injury that can have lifelong implications. Despite advances in prevention, diagnosis, monitoring, and treatment, the degree of recovery can vary widely between patients. Much of this is explained by differences in severity of impact and patient-specific comorbidities; however, even among nearly identical patients, stark disparities can arise. Researchers have looked to genetics in recent years as a means of explaining this phenomenon. It has been hypothesized that individual genetic factors can influence initial inflammatory responses, recovery mechanisms, and overall prognoses. In this review, we focus on cytokine polymorphisms, mitochondrial DNA (mtDNA) haplotypes, immune cells, and gene therapy given their associated influx of novel research and magnitude of potential. This discussion is prefaced by a thorough background on TBI pathophysiology to better understand where each mechanism fits within the disease process. Cytokine polymorphisms causing unfavorable regulation of genes encoding IL-1β, IL-RA, and TNF-α have been linked to poor TBI outcomes like disability and death. mtDNA haplotype H has been correlated with deleterious effects on TBI recovery time, whereas haplotypes K, T, and J have been depicted as protective with faster recovery times. Immune cell genetics such as microglial differentially expressed genes (DEGs), monocyte receptor genes, and regulatory factors can be both detrimental and beneficial to TBI recovery. Gene therapy in the form of gene modification, inactivation, and editing show promise in improving post-TBI memory, cognition, and neuromotor function. Limitations of this study include a large proportion of cited literature being focused on pre-clinical murine models. Nevertheless, favorable evidence on the role of genetics in TBI recovery continues to grow. We aim for this work to inform interested parties on the current landscape of research, highlight promising targets for gene therapy, and galvanize translation of findings into clinical trials.
Unveiling the Role of Hydrolytic Enzymes from Soil Biocontrol Bacteria in Sustainable Phytopathogen Management
Authors: Saberi Riseh Roohallah , Vatankhah Masoumeh , Hassanisaadi Mohadeseh , Barka Essaid Ait
Published: March 2024

Background: Phytopathogens, encompassing fungi, bacteria, viruses, and nematodes, pose a significant threat to the agricultural industry by causing substantial economic losses through severe plant diseases. The excessive use of synthetic fungicides to combat phytopathogens has raised environmental and human health concerns. Results: Consequently, there is an increasing demand for safe and environmentally friendly biopesticides to align with consumer preferences for uncontaminated food. One particularly promising alternative to synthetic fungicides involves harnessing biocontrol bacteria that produce extracellular hydrolytic enzymes. These enzymes serve to effectively manage phytopathogens while concurrently fostering sustainable plant protection. Among the pivotal hydrolytic enzymes generated by biocontrol bacteria are chitinase, cellulase, protease, lipase, glucanase, and amylase. These enzymes exert their influence by breaking down the cell wall, proteins, and DNA of phytopathogens, thereby establishing a dependable method of biocontrol. Conclusions: Recognizing the critical role of these hydrolytic enzymes in sustainable biocontrol, this review seeks to delve into their primary functions, contribution to sustainable plant protection, and mechanisms of action. Through an exploration of the potential presented by biocontrol bacteria and their enzymatic mechanisms, we can discern effective and environmentally conscious strategies for managing phytopathogens in agriculture.
CD6 and CCR7 as Genetic Biomarkers in Evaluating Intracranial Aneurysm Rupture Risk
Authors: Xu Dan-Dan , Liu Xiao-Qiang , Wu Zhi-Sheng
Published: March 2024

Background: This study used bioinformatics combined with statistical methods to identify plasma biomarkers that can predict intracranial aneurysm (IA) rupture and provide a strong theoretical basis for the search for new IA rupture prevention methods. Methods: We downloaded gene expression profiles in the GSE36791 and GSE122897 datasets from the Gene Expression Omnibus (GEO) database. Data were normalized using the “sva” R package and differentially expressed genes (DEGs) were identified using the “limma” R package. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were used for DEG function analysis. Univariate logistic regression analysis, least absolute shrinkage and selection operator (LASSO) regression modeling, and the support vector machine recursive feature elimination (SVM-RFE) algorithm were used to identify key biomarker genes. Data from GSE122897 and GSE13353 were extracted to verify our findings. Results: Eight co-DEG mRNAs were identified in the GSE36791 and GSE122897 datasets. Genes associated with inflammatory responses were clustered in the co-DEG mRNAs in IAs. CD6 and C-C chemokine receptor 7 (CCR7) were identified as key genes associated with IA. CD6 and CCR7 were upregulated in patients with IA and their expression levels were positively correlated. There were significant differences in the infiltration of immune cells between IAs and normal vascular wall tissues (p < 0.05). A predictive nomogram was designed using this two-gene signature. Binary transformation of CD6 and CCR7 was performed according to the cut-off value to construct the receiver-operating characteristic (ROC) curve and showed a strong predictive ability of the CD6-CCR7 gene signature (p < 0.01; area under the curve (AUC): 0.90; 95% confidence interval (CI): 0.88–0.92). Furthermore, validation of this two-gene signature using the GSE122897 and GSE13353 datasets proved it to be valuable for clinical application. Conclusions: The identified two-gene signature (CD6-CCR7) for evaluating the risk of IA rupture demonstrated good clinical application value.
Development and Implementation of a Dynamically Updated Big Data Intelligence Platform Using Electronic Medical Records for Secondary Hypertension
Authors: Li Nanfang , Zhu Qing , Dang Yujie , Zhou Yin , Cai Xintian , Heizhati Mulalibieke , Zhang Delian , Yao Xiaoguang , Luo Qin , Hu Junli , Wang Guoliang , Wang Yingchun , Wang Menghui , Hong Jing
Published: March 2024

Background: The accurate identification and diagnosis of secondary hypertension is critical,especially while cardiovascular heart disease continues to be the leading cause of death. To develop a big data intelligence platform for secondary hypertension using electronic medical records to contribute to future basic and clinical research. Methods: Using hospital data, the platform, named Hypertension DATAbase at Urumchi (UHDATA), included patients diagnosed with hypertension at the People’s Hospital of Xinjiang Uygur Autonomous Region since December 2004. The electronic data acquisition system, the database synchronization technology, and data warehouse technology (extract–transform–load, ETL) for the scientific research big data platform were used to synchronize and extract the data from each business system in the hospital. Standard data elements were established for the platform, including demographic and medical information. To facilitate the research, the database was also linked to the sample database system, which includes blood samples, urine specimens, and tissue specimens. Results: From December 17, 2004, to August 31, 2022, a total of 295,297 hypertensive patients were added to the platform, with 53.76% being males, with a mean age of 59 years, and 14% with secondary hypertension. However, 75,802 patients visited the Hypertension Center at our hospital, with 43% (32,595 patients) being successfully diagnosed with secondary hypertension. The database contains 1458 elements, with an average fill rate of 90%. The database can continuously include the data for new hypertensive patients and add new data for existing hypertensive patients, including post-discharge follow-up information, and the database updates every 2 weeks. Presently, some studies that are based on the platform have been published. Conclusions: Using computer information technology, we developed and implemented a big database of dynamically updating electronic medical records for patients with hypertension, which is helpful in promoting future research on secondary hypertension.
Comparison of Jailed Wire and Jailed Balloon for Prevention of Side Branch Occlusion in Provisional Stenting: Evidence from a Systematic Review and Meta-Analysis
Authors: Li Dongdong , Liu Hao , Dai Huimiao , Gao Chuncheng , Yang Pei , Guo Wangang
Published: March 2024

Background: Side branch (SB) occlusion after main vessel stenting is the main complication in treating coronary bifurcation lesions by provisional stenting. The Jailed Wire Technique (JWT), recommended by the European Bifurcation Club, is a standard technique to deal with this issue. The Jailed Balloon Technique (JBT) has been found to be more effective than the JWT in clinical practice by some interventionists, but it has not been widely accepted. In this meta-analysis, we compared the efficacy and safety of JBT and JWT. Methods: The literature comparing JBT and JWT was systematically reviewed. Stata/MP 17.0 was used to perform a meta-analysis. The primary endpoints were major adverse cardiac events (MACE), cardiac death, myocardial infarction (MI) and target lesion revascularization (TLR). The secondary endpoints were SB occlusion and SB dissection. Aggregated odds ratios and 95% confidence intervals were calculated. A sensitivity analysis was conducted if I2 was >50% or p < 0.01. Results: Thirteen studies involving 1789 patients were enrolled. JBT was found to have a significantly lower incidence of MACE, SB occlusion and dissection. The incidence of cardiac death, MI and TLR were also lower in the JBT group, though the differences were not significant. Conclusions: JBT prevents SB occlusion more effectively and does not increase immediate or long-term complications. JBT, or its modified versions, can be used to treat SBs with a high risk of occlusion.
The Role of Coronary Physiology Assessment in the Diagnosis and Treatment of Stable Angina. Dive Inside Recent Findings of Diffuse Coronary Disease Treatment
Authors: Chioncel Valentin , Gherasie Flavius-Alexandru
Published: March 2024

Coronary physiology is widely used to assess epicardial coronary lesions in patients with stable angina. Based on the available evidence, physiology plays a crucial role in diagnosing and treating patients. There have been invasive methods for determining cardiac physiology, such as fractional flow reserve and instantaneous wave-free ratio. Still, new non-invasive approaches provide extra anatomical information, such as fractional flow reserve computed tomography (FFR-CT) based on computed tomography and physiology based on angiography. Even though FFR-guided percutaneous coronary intervention (PCI) is clinically beneficial, one-third of patients retain suboptimal FFR after the procedure, associated with severe adverse events, rendering PCI in diffuse coronary artery disease questionable. Using the pullback pressure gradient (PPG), we can analyze the magnitude and extent of pressure losses; a lower value may indicate diffuse disease, while a high value with an abrupt curve may indicate focal disease. Since PCI is not the best option for treating diffuse coronary disease, current strategies focus on conservatively using medical therapy or bypass surgery. It has been demonstrated that patients with diffuse disease of the left anterior descending (LAD) are at a greater risk of developing occlusion of the left internal mammary artery graft than those with focal disease and that maximal medical therapy may be the most effective treatment for these patients.
The Upper Common Pathway in Atrioventricular Nodal Reentrant Tachycardia: A Comprehensive Review of Evidence and Current Perspectives
Authors: Park Soyoon , Park Jeong-Wook , Choi Young
Published: March 2024

Atrioventricular nodal reentrant tachycardia (AVNRT) is the most common form of paroxysmal supraventricular tachycardia, and its diagnostic and therapeutic approaches have been well-established. Traditionally, AVNRT is understood to be an intranodal reentry having two bystander pathways; the upper common pathway (UCP) which connects to the atrium and the lower common pathway which connects to the ventricle. However, the existence of the UCP remains a subject of ongoing debate. The assertion of the UCP’s presence is supported by electrophysiological evidence suggesting that the atrium is not essential for the perpetuation of AVNRT. Nonetheless, numerous anatomical studies have failed to identify any structure that could be conclusively designated as the UCP. The histological and electrophysiological characteristics of the slow and fast pathways, which are the core components of AVNRT, suggest the inclusion of atrial myocardium in the reentry circuit. While clear interpretation of these discrepancies remains elusive, potential explanations may be derived from existing evidence and recent research findings concerning the actual AVNRT circuit.
Pengantar
Authors: BMKG JMG
Published: March 2024

Pengantar JMG Vol 11 No. 2
The impact of emojis on verbal irony comprehension in computer-mediated communication: A cross-cultural study
Authors: Du Yiran
Published: March 2024

This study examines the influence of emojis on the comprehension of verbal irony in computer-mediated communication (CMC), with a focus on cross-cultural comparisons between Chinese and American participants. Verbal irony, often reliant on paralinguistic cues absent in text-based communication, poses comprehension challenges in CMC. Emojis, as nonverbal cues, are hypothesized to aid in conveying and interpreting ironic intent. The research involved 96 participants, equally divided between the two cultures, who were presented with scenarios containing verbal irony accompanied by either a winking or smiling emoji, or no emoji. The findings suggest significant cross-cultural differences in irony comprehension facilitated by emojis. American participants showed improved irony comprehension with the winking emoji, aligning with its conventional association with sarcasm in Western cultures. Conversely, Chinese participants better understood irony when paired with the smiling emoji, highlighting cultural variations in emoji interpretation. The study underscores the complex role of cultural context in digital communication.
Behavioural determinants of physiologically-relevant light exposure
Authors: Biller Anna Magdalena , Balakrishnan Priji , Spitschan Manuel
Published: March 2024

Light exposure triggers a range of physiological and behavioural responses that can improve and challenge health and well-being. Insights from laboratory studies have recently cumulated in standards and guidelines for measuring and assessing healthy light exposure, and recommendations for healthy criterion light levels. Implicit to laboratory paradigms is a simplistic input-output relationship between light and its effects on physiology. This ignores that humans actively shape their lighting environment through behaviour. We present a novel framework that conceptualizes light exposure as an individual behaviour to meet specific, person-based needs. Key to healthy light exposure is also shaping behaviour, beyond shaping technology.
Atypical speech production of multisyllabic items by children with developmental language disorder (DLD) indicate prosodic difficulties
Authors: Parvez Lyla , Keshavarzi Mahmoud , Richards Susan , Di Liberto Giovanni M. , Goswami Usha
Published: March 2024

Purpose: Developmental language disorder (DLD) is typically characterized by a core grammatical impairment, yet spoken word production can also exhibit atypical phonology, for example the omission of unstressed syllables. This may indicate a role for the sensory/neural processing of syllable stress patterns in the aetiology of DLD. Here we explore this connection by investigating the accuracy of the production of multisyllabic words from a speech rhythm/syllable stress perspective.Method: We adapted a computerized speech copying task originally designed for children with dyslexia, in which participants copy aloud familiar targets like “alligator”. Fifty-seven children with and without DLD were tested with a 30-item battery comprising equal numbers of 2-syllable, 3-syllable and 4-syllable words. The children with DLD (N=20) were compared with both age-matched typically-developing control children (AMC, N=21) and younger typically-developing control children with less mature language skills (younger language controls, YLC, N=16). Similarity of the child’s productions to the target in terms of the speech amplitude envelope (AE) and pitch contour was computed using two similarity metrics, correlation and mutual information. Both the speech AE and the pitch contour contain important information about stress patterns and intonational information.Results: Children with DLD were significantly less accurate than AMC at copying the multi-syllabic targets, for both the AE and the pitch contour. The opportunity to repeat the targets had no impact on performance, for any group. Word length effects were similar across groups. Conclusion: The spoken production of multisyllabic words by children with DLD is atypical regarding both the AE and the pitch contour. This is consistent with a theoretical explanation of DLD based on impaired sensory/neural processing of speech rhythm.
When Imagination Feels Like Reality: A Case Study of False Memories and Maladaptive Daydreaming in Visual Impairment
Authors: Somer Eli
Published: March 2024

Background: When a person experiences maladaptive daydreaming (MD), they spend a prolonged period daydreaming with a strong sense of presence. MD symptoms are often excessive, interfere with functioning, and are linked to distress and comorbid mental disorders. In this paper, apparent false memory is described in the context of a woman with MD and visual impairment due to a progressive eye condition. Her vivid daydreams seemed indistinguishable from actual memories. Case Report: A 35-year-old woman with a lifelong MD reported three incidents of fabricating detailed false memories of events that her family confirmed never occurred: obtaining a new job, miscarrying twins, and hospitalization for the coronavirus disease 2019 (COVID-19). She experienced anxiety and shame when the stories were disproven. The assessment confirmed MD, PTSD, OCD, and other disorders. Her verbal memory was below average, especially for longer narratives. Her misattributions of daydreams as real-life memories may relate to reliance on vivid mental images over deteriorating vision and source monitoring deficits. Conclusion: This first reported case of confabulations in an individual with MD and visual disability suggests daydreams could potentially be mistaken for actual events in some MD cases. While sensitive, more research is needed on the prevalence of false memories among individuals with MD. The default mode network, prefrontal cortex, and their connectivity may be implicated in generating vivid daydreams and misattributing them to actual episodic events. Understanding the relationship between sensory impairments, dissociation, and susceptibility to memory distortions could inform interventions to improve reality testing for some MD patients.
Tone language experience enhances dimension-selective attention and subcortical encoding but not cortical entrainment to pitch
Authors: Kachlicka Magdalena , Symons Ashley E , Saito Kazuya , Dick Frederic , Tierney Adam
Published: March 2024

What factors determine the importance placed on different sources of evidence during speech and music perception? Attention-to-dimension theories suggest that, through prolonged exposure to their first language (L1), listeners become biased to attend to acoustic dimensions especially informative in that language. Given that selective attention can modulate cortical tracking of sound, attention-to-dimension accounts would predict that tone language speakers would show greater cortical tracking of pitch in L2 speech, even when it is not task-relevant, as well as an enhanced ability to attend to pitch in both speech and music. Here we test these hypotheses by examining neural sound encoding, dimension-selective attention and cue-weighting strategies in 54 native English and 60 Mandarin Chinese speakers. Our results show that Mandarin speakers, compared to native English speakers, are better at attending to pitch and worse at attending to duration in verbal and non-verbal stimuli; moreover, they place more importance on pitch and less on duration during speech and music categorization. The effects of language background were moderated by musical experience, however, with Mandarin-speaking musicians better able to attend to duration and using duration more as a cue to phrase boundary perception. There was no effect of L1 on cortical tracking of acoustic dimensions. Nevertheless, the frequency-following response to stimulus pitch was enhanced in Mandarin speakers, suggesting that speaking a tone language can boost processing of early pitch encoding. These findings suggest that tone language experience does not increase the tendency for pitch to capture attention, regardless of task; instead, tone language speakers may benefit from an enhanced ability to direct attention to pitch when it is task-relevant, without affecting pitch salience.
School-Based Interventions for Children with Behavioral Difficulties: Suboptimal Implementation of Evidence-Based Practices
Authors: Steenweg Elisa M. , Dekkers Tycho , Doffer Dominique Petra Amadee , van den Hoofdakker Barbara , Groenman Annabeth , Luman Marjolein
Published: March 2024

Children with behavioral difficulties and their teachers frequently experience challenges at school, leading to school-based interventions. Here, we evaluated the utilization and evidence-base of school-based interventions for behavioral difficulties. We conducted a survey among 102 school mental health professionals and asked about their utilization of 22 school-based interventions, whereafter we evaluated the evidence-base of these interventions. We also assessed professionals’ attitudes towards evidence-based practice, knowledge about behavioral problems, and their educational background, to analyze associations with the use of evidence-based interventions. We found large heterogeneity in evidence-based practice: 18.6% of school mental health professionals only used evidence-based interventions, and another 38.2% reported to use at least one evidence-based intervention alongside the use of interventions without evidence base. However, 26.5% of the professionals did use interventions for children with behavioral difficulties, but none of these was evidence-based, and 16.7% did not use any intervention at all. In addition, we found that about half of the currently used school-based interventions for children with behavioral difficulties lack empirical support and that interventions that are evidence-based and specifically developed for children with behavioral difficulties are hardly used. None of our potential predictors were related to the use of evidence-based interventions. We underscore the need for a better implementation of effective school-based interventions for children with behavioral difficulties. This would require a multifaceted approach encompassing research into promising interventions, de-implementation of interventions that lack evidence, more insight into factors facilitating the implementation of evidence-based interventions, and more rigorous support for implementing evidence-based interventions in schools.