bluuebunny/crossref_metadata_2025 huggingface dataset:
Whole-Body Vibration Impacts on the Degree of Toe Angle and Its Correlation to the Knee Osteoarthritis Index during Level Walking among Female University Students: A Randomized Controlled Trial
Authors: Abd-Eltawab Amany E. , Elbandrawy Asmaa M. , Ghanem Heba B. , Ebrahim Hasnaa A. , El-Sherbiny Mohamed , Ibrahim Ateya Megahed , Eladl Mohamed Ahmed , Elsherbini Dalia Mahmoud Abdelmonem
Published: September 2023

Whole-body vibration (WBV) training is used for ankle rehabilitation as it stimulates muscle spindles to excite tonic vibration reflexes, and improves muscle strength, power, joint proprioception, balance, and flexibility. Thus, this study aims to determine the impact of whole-body vibration on the degree of the toe angle and the correlation between the toe angle and knee osteoarthritis index during level walking among female university students. A randomized controlled trial was conducted with 42 participants divided into two groups. The control group performed only home-based exercise (HBE) after education, and the study group received WBV with HBE. The functional status of participants to predict osteoarthritis was evaluated using the Western Ontario and McMaster osteoarthritis index (WOMAC), where the toe angle degree and WOMAC index were assessed before and six weeks after training. The results showed a significant improvement in the toe-in angle of HBE + WBV compared to the HBE group (p = 0.02), and in HBE + WBV, an improvement of the toe angle showed a 43% decrease in the WOMAC index (p = 0.001). In conclusion, WBV for the ankle and foot training program positively affected the degree of the toe angle, that directly affected the subtalar and ankle joint mechanics. Trial registration in the Pan African Clinical Trial Registry PACTR202304816093190 (registered retrospectively, date of registration: 18 April 2023).
Use of Apolipoprotein B in the Era of Precision Medicine: Time for a Paradigm Change?
Authors: Cole Justine , Zubirán Rafael , Wolska Anna , Jialal Ishwarlal , Remaley Alan
Published: September 2023

Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of death worldwide and the risk of a major cardiovascular event is highest among those with established disease. Ongoing management of these patients relies on the accurate assessment of their response to any prescribed therapy, and their residual risk, in order to optimize treatment. Recent international guidelines and position statements concur that the plasma concentration of apolipoprotein B (apoB) is the most accurate measure of lipoprotein associated ASCVD risk. This is especially true for the growing number of individuals with diabetes, obesity, or the metabolic syndrome, and those on statin therapy. Most guidelines, however, continue to promote LDL-C as the primary risk marker due to uncertainty as to whether the greater accuracy of apoB is sufficient to warrant a paradigm shift. Recommendations regarding apoB measurement vary, and the information provided on how to interpret apoB results is sometimes insufficient, particularly for non-lipid specialists. Misinformation regarding the reliability of the assays is also frequently repeated despite its equivalent or better standardization than many other diagnostic assays. Thus, demand for apoB testing is relatively low, which means there is little incentive to increase its availability or reduce its cost. In this review, we examine the results of recent clinical outcomes studies and meta-analyses on the relative values of apoB, LDL-C, and non-HDL-C as markers of ASCVD risk. Although there is seemingly minimal difference among these markers when only population-based metrics are considered, it is evident from our analysis that, from a personalized or precision medicine standpoint, many individuals would benefit, at a negligible total cost, if apoB measurement were better integrated into the diagnosis and treatment of ASCVD.
Comprehensive Geriatric Assessment and Quality of Life Aspects in Patients with Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (HNSCC)
Authors: Winter Anna , Schulz Stefan M. , Schmitter Marc , Müller-Richter Urs , Kübler Alexander , Kasper Sylvia , Hartmann Stefan
Published: September 2023

To define frailty in older cancer patients, the aim of this study was to assess the geriatric status and quality of life (QoL) aspects in patients suffering from recurrent/metastatic head and neck squamous cell carcinoma (r/m HNSCC) under palliative treatment. A comprehensive geriatric assessment (CGA) was performed on 21 r/m HNSCC patients at two defined assessments, and the QoL aspects and the impact of descriptive data were evaluated. The Kolmogorov–Smirnov test, Spearman’s rho correlation, and two-way mixed ANOVA were used for statistical analysis. All patients were found to be “frail”. Pain, fatigue, and the burden of illness were the highest-rated symptoms. Oral function and orofacial appearance were highly impaired. A significant impact of descriptive data on the CGA and QoL results was found (all p ≤ 0.05). Thus, the CGA results revealed high frailty, severe comorbidities, and high impairments in QoL aspects. The CGA and QoL results were negatively affected by the primary HNSCC treatment approach, the need for prosthetic treatment, and worse oral functional capacity. Therefore, frailty in r/m HNSCC patients seems to be multidimensional. The evaluation of the CGA and QoL aspects in r/m HNSCC patients can be recommended to detect special needs, organize aftercare, and improve the support for frail and vulnerable cancer patients to create a multidisciplinary treatment approach.
Forging Ahead in Cardiovascular Disease Management
Authors: Domienik-Karlowicz Justyna , Ciurzynski Michał
Published: September 2023

The common threat of cardiovascular diseases (CVDs) constantly holds a dominant position among the leading causes of global mortality [...]
Early Biological Valve Failure: Structural Valve Degeneration, Thrombosis, or Endocarditis?
Authors: Fazzari Fabio , Baggiano Andrea , Fusini Laura , Ghulam Ali Sarah , Gripari Paola , Junod Daniele , Mancini Maria Elisabetta , Maragna Riccardo , Mushtaq Saima , Pontone Gianluca , Pepi Mauro , Muratori Manuela
Published: September 2023

Biological valve failure (BVF) is an inevitable condition that compromises the durability of biological heart valves (BHVs). It stems from various causes, including rejection, thrombosis, and endocarditis, leading to a critical state of valve dysfunction. Echocardiography, cardiac computed tomography, cardiac magnetic resonance, and nuclear imaging play pivotal roles in the diagnostic multimodality workup of BVF. By providing a comprehensive overview of the pathophysiology of BVF and the diagnostic approaches in different clinical scenarios, this review aims to aid clinicians in their decision-making process. The significance of early detection and appropriate management of BVF cannot be overstated, as these directly impact patients’ prognosis and their overall quality of life. Ensuring timely intervention and tailored treatments will not only improve outcomes but also alleviate the burden of this condition on patients’ life. By prioritizing comprehensive assessments and adopting the latest advancements in diagnostic technology, medical professionals can significantly enhance their ability to manage BVF effectively.
Transforaminal Endoscopic Lumbar Foraminotomy for Juxta-Fusional Foraminal Stenosis
Authors: Ahn Yong , Park Han-Byeol
Published: September 2023

Adjacent segment foraminal stenosis is a significant adverse event of lumbar fusion. Conventional revision surgery with an extended fusion segment may result in considerable surgical morbidity owing to extensive tissue injury. Transforaminal endoscopic lumbar foraminotomy (TELF) is a minimally invasive surgical approach for symptomatic foraminal stenosis. This study aimed to demonstrate the surgical technique and clinical outcomes of TELF for the treatment of juxta-fusional foraminal stenosis. Full-scale foraminal decompression was performed via a transforaminal endoscopic approach under local anesthesia. A total of 22 consecutive patients who had undergone TELF were evaluated. The included patients had unilateral foraminal stenosis at the juxta-fusional level of the previous fusion surgery, intractable lumbar radicular pain despite at least six months of non-operative treatment, and verified pain focus by imaging and selective nerve root block. The visual analog scale and Oswestry Disability Index scores significantly improved after the two-year follow-up period. The modified MacNab criteria were excellent in six patients (27.27%), good in 12 (55.55%), fair in two (9.09%), and poor in two (9.09%), with a 90.91% symptomatic improvement rate. No significant surgical complications were observed. The minimally invasive TELF is effective for juxta-fusional foraminal stenosis.
Management and Prognosis of Acute Stroke in Atrial Fibrillation
Authors: Hindsholm Mette F. , Damgaard Dorte , Gurol M. Edip , Gaist David , Simonsen Claus Z.
Published: September 2023

Atrial fibrillation (AF) is an important risk factor for ischemic stroke (IS). Oral anticoagulation (OAC) significantly reduces the risk of IS in AF but also increases the risk of systemic bleeding, including intracerebral hemorrhage (ICH). AF-related strokes are associated with greater disability and mortality compared to non-AF strokes. The management of patients with AF-related strokes is challenging, and it involves weighing individual risks and benefits in the acute treatment and preventive strategies of these patients. This review summarizes the current knowledge of the acute management of ischemic and hemorrhagic stroke in patients with AF, and the prognosis and potential implications for management both in the acute and long-term setting.
Is There an Association between Post-Traumatic Stress Disorder and the Incidence of Chronic Low Back Pain?
Authors: Kostev Karel , Smith Lee , Haro Josep Maria , Konrad Marcel , Koyanagi Ai , Jacob Louis
Published: September 2023

Background: Preliminary research suggests post-traumatic stress disorder (PTSD) is a risk factor for chronic low back pain (CLBP). However, this literature displays some limitations. Therefore, this study aimed to investigate the association between PTSD and the 10-year cumulative incidence of CLBP in adults from Germany. Methods: The present retrospective cohort study included adults diagnosed with PTSD in 1 of 1284 general practices in Germany in 2005–2020 (index date). Individuals without PTSD were matched to those with PTSD (1:1) using a propensity score based on age, sex, index year, duration of follow-up, and the mean number of consultations during follow-up. In patients without PTSD, the index date was a randomly selected visit date. Results: There were 60,664 patients included in the study. After adjusting for frequent comorbidities, there was a positive but non-significant association between PTSD and incident CLBP in the overall population (HR = 1.07, 95% CI = 0.99–1.15). Nonetheless, the relationship between PTSD and CLBP was statistically significant in the age group >60 years (HR = 1.24, 95% CI = 1.05–1.46). Conclusions: Conversely to previous research, PTSD was not associated with incident CLBP in this large German sample. Further longitudinal studies are warranted to corroborate these findings before drawing any firm conclusions.
Identifying Developmental Language Disorder in Deaf Children with Cochlear Implants: A Case Study of Three Children
Authors: Hardman Gemma , Herman Rosalind , Kyle Fiona Elizabeth , Ebbels Susan , Morgan Gary
Published: September 2023

(1) Background: While spoken language learning delays are assumed for deaf and hard of hearing (DHH) children after cochlear implant (CI), many catch up with their hearing peers. Some DHH children with CIs, however, show persistent delays in language, despite protective factors being in place. This suggests a developmental language disorder (DLD). However, at present there is little consensus on how to diagnose DLD in DHH children. (2) Methods: Given the lack of consensus in this area, a set of case studies provides an appropriate first step. The goal of this paper is to show the plausibility of a DLD diagnosis, following careful analysis of protective and risk factors. A retrospective case study review was conducted for three children. Their long-term language outcomes up to four years after CI were considered in the context of access to sound, speech sound discrimination, social skills and non-verbal cognition. (3) Results: It was possible to posit DLD in one child who had experienced good access to sound, alongside good speech discrimination abilities and social development, and normal non-verbal cognition, but who presented with severe language learning difficulties. (4) Conclusions: Finding markers for DLD in DHH children is important for diagnosis and intervention. The implications for clinical practice are discussed.
Transcutaneous CO2 Monitoring in Extremely Low Birth Weight Premature Infants
Authors: Borenstein-Levin Liron , Avishay Noa , Soffer Orit , Arnon Shmuel , Riskin Arieh , Dinur Gil , Lavie-Nevo Karen , Gover Ayala , Kugelman Amir , Hochwald Ori
Published: September 2023

Extremely low birth weight (ELBW) premature infants are particularly susceptible to hypocarbia and hypercarbia, which are associated with brain and lung morbidities. Transcutaneous CO2 (TcCO2) monitoring allows for continuous non-invasive CO2 monitoring during invasive and non-invasive ventilation and is becoming more popular in the NICU. We aimed to evaluate the correlation and agreement between CO2 levels measured by a TcCO2 monitor and blood gas CO2 (bgCO2) among ELBW infants. This was a prospective observational multicenter study. All infants < 1000 g admitted to the participating NICUs during the study period were monitored by a TcCO2 monitor, if available. For each bgCO2 measured, a simultaneous TcCO2 measurement was documented. In total, 1828 pairs of TcCO2–bgCO2 values of 94 infants were collected, with a median (IQR) gestational age of 26.4 (26.0, 28.3) weeks and birth weight of 800 (702, 900) g. A moderate correlation (Pearson: r = 0.64) and good agreement (bias (95% limits of agreement)):(2.9 [−11.8, 17.6] mmHg) were found between the TcCO2 and bgCO2 values in the 25–70 mmHg TcCO2 range. The correlation between the TcCO2 and bgCO2 trends was moderate. CO2 measurements by TcCO2 are in good agreement (bias < 5 mmHg) with bgCO2 among premature infants < 1000 g during the first week of life, regardless of day of life, ventilation mode (invasive/non-invasive), and sampling method (arterial/capillary/venous). However, wide limits of agreement and moderate correlation dictate the use of TcCO2 as a complementary tool to blood gas sampling, to assess CO2 levels and trends in individual patients.
Pancreaticobiliary Diseases with Severe Complications as a Rare Indication for Emergency Pancreaticoduodenectomy: A Single-Center Experience and Review of the Literature
Authors: Fickenscher Maximilian , Vorontsov Oleg , Müller Thomas , Radeleff Boris , Graeb Christian
Published: September 2023

The pancreaticobiliary system is a complex and vulnerable anatomic region. Small changes can lead to severe complications. Pancreaticobiliary disorders leading to severe complications include malignancies, pancreatitis, duodenal ulcer, duodenal diverticula, vascular malformations, and iatrogenic or traumatic injuries. Different therapeutic strategies, such as conservative, interventional (e.g., embolization, stent graft applications, or biliary interventions), or surgical therapy, are available in early disease stages. Therapeutic options in patients with severe complications such as duodenal perforation, acute bleeding, or sepsis are limited. If less invasive procedures are exhausted, an emergency pancreaticoduodenectomy (EPD) can be the only option left. The aim of this study was to analyze a single-center experience of EPD performed for benign non-trauma indications and to review the literature concerning EPD. Between January 2015 and January 2022, 11 patients received EPD due to benign non-trauma indications at our institution. Data were analyzed regarding sex, age, indication, operative parameters, length of hospital stay, postoperative morbidity, and mortality. Furthermore, we performed a literature survey using the PubMed database and reviewed reported cases of EPD. Eleven EPD cases due to benign non-trauma indications were analyzed. Indications included peptic duodenal ulcer with penetration into the hepatopancreatic duct and the pancreas, duodenal ulcer with acute uncontrollable bleeding, and penetration into the pancreas, and a massive perforated duodenal diverticulum with peritonitis and sepsis. The mean operative time was 369 min, and the median length of hospital stay was 35.8 days. Postoperative complications occurred in 4 out of 11 patients (36.4%). Total 90-day postoperative mortality was 9.1% (1 patient). We reviewed 17 studies and 22 case reports revealing 269 cases of EPD. Only 20 cases of EPD performed for benign non-trauma indications are reported in the literature. EPD performed for benign non-trauma indications remains a rare event, with only 31 reported cases. The data analysis of all available cases from the literature revealed an increased postoperative mortality rate of 25.8%. If less invasive approaches are exhausted, EPD is still a life-saving procedure with acceptable results. Performed by surgeons with a high level of experience in hepatobiliary and pancreatic surgery, mortality rates below 10% can be achieved.
Outcomes of the Next In Vitro Fertilization Cycle in Women with Polycystic Ovary Syndrome after a Failed In Vitro Maturation Attempt
Authors: Guo Wei , Xu Yalan , Tian Tian , Yang Shuo , Li Rong , Qiao Jie , Zheng Xiaoying
Published: September 2023

Background: In vitro maturation (IVM) is indicated in women with polycystic ovary syndrome (PCOS) who have a very good ovarian response during in vitro fertilization (IVF) and are therefore at high risk of ovarian hyperstimulation syndrome (OHSS). According to the latest practice committee document, IVM could be a major advance in assisted reproductive technology (ART) procedures (reduced cost and simplified treatment); nevertheless, retrospective studies of IVM versus IVF still demonstrate lower chances of a live birth with IVM. Could IVM prove to be an optimal first-line treatment approach? And limited information is available concerning the success of the subsequent IVF cycle after the failure of an IVM cycle. Does IVM treatment adversely affect the subsequent IVF cycle, and is this worth considering before performing the IVF cycle for women with PCOS? Methods: This prospective nested case–control study at the Peking University Reproductive Medicine center in China was performed between March 2018 and September 2020. Women aged 20–38 years with PCOS and infertility and who were scheduled for their first IVF attempt were eligible. A total of 351 women were randomly allocated to receive one cycle of unstimulated natural IVM (n = 175) or one cycle of standard IVF with a flexible GnRH antagonist protocol followed by hCG as an ovulation trigger (n = 176). This study involved 234 women (58 women with no blastocysts in the first IVM cycle and 158 women who underwent the first IVF cycle). Cumulative live birth rate at 12 months after oocyte retrieval and OHSS of a standard controlled ovarian stimulation (COS) IVF cycle were compared between 58 women in an IVF cycle following a failed IVM cycle and 158 women who underwent the first IVF cycle. Results: No significant differences were found in the cumulative live birth rate (CLBR), ongoing pregnancy rate, or clinical pregnancy rate at 12 months after oocyte retrieval between the two groups (56.9% vs. 58.9%, p = 0.795; 58.6% vs. 60.8%, p = 0.776; and 84.5% vs. 76.0%, p = 0.178). The incidence of moderate-to-severe OHSS was not significantly different between the groups (6.9% vs. 5.7%, p = 0.742). Additionally, there were no significant differences in the total gonadotropin dose, stimulation duration, number of retrieved oocytes, number of retrieved mature oocytes, or fertilization rates. Conclusions: Even if the first IVM attempt failed in subfertile women with PCOS, comparable cumulative live birth rates were observed in the subsequent IVF cycle. IVM treatment does not adversely affect the subsequent IVF cycle.
High Thyroid-Stimulating Hormone and Low Free Triiodothyronine Levels Are Associated with Chronic Kidney Disease in Three Population-Based Studies from Germany
Authors: Ittermann Till , von Rheinbaben Sabrina , Markus Marcello R. P. , Dörr Marcus , Steveling Antje , Nauck Matthias , Teumer Alexander , Gollasch Maik , Spira Dominik , König Maximilian , Demuth Ilja , Steinhagen-Thiessen Elisabeth , Völzke Henry , Stracke Sylvia
Published: September 2023

High serum thyroid-stimulating hormone (TSH) levels have previously been associated with a low estimated glomerular filtration rate (eGFR), but studies associating thyroid hormone levels with albuminuria revealed inconsistent results. We used cross-sectional data from 7933 individuals aged 20 to 93 years of the Berlin Aging Study II and the Study of Health in Pomerania to associate serum TSH, fT3, and fT4 levels with eGFR and albuminuria. In multivariable analyses adjusted for confounding, we found inverse non-linear associations of serum TSH levels with eGFR, while serum fT3 levels showed a positive association with eGFR. High as well as low serum fT4 levels were associated with a lower eGFR. Age but not sex modified the association between thyroid hormone levels and eGFR. The inverse associations between serum TSH levels and eGFR were strongest in the youngest age groups, while the positive associations between serum fT3 levels and eGFR were strongest in older individuals. No significant associations between thyroid hormone levels and albuminuria were found. Our results indicate that hypothyroidism might be associated with a reduced kidney function. Thyroid function might be more tightly related to the eGFR than to albuminuria in the general population.
Biosynthesis of Functional Silver Nanoparticles Using Callus and Hairy Root Cultures of Aristolochia manshuriensis
Authors: Yugay Yulia A. , Sorokina Maria R. , Grigorchuk Valeria P. , Rusapetova Tatiana V. , Silant’ev Vladimir E. , Egorova Anna E. , Adedibu Peter A. , Kudinova Olesya D. , Vasyutkina Elena A. , Ivanov Vladimir V. , Karabtsov Alexander A. , Mashtalyar Dmitriy V. , Degtyarenko Anton I. , Grishchenko Olga V. , Kumeiko Vadim V. , Bulgakov Victor P. , Shkryl Yury N.
Published: September 2023

This study delves into the novel utilization of Aristolochia manshuriensis cultured cells for extracellular silver nanoparticles (AgNPs) synthesis without the need for additional substances. The presence of elemental silver has been verified using energy-dispersive X-ray spectroscopy, while distinct surface plasmon resonance peaks were revealed by UV-Vis spectra. Transmission and scanning electron microscopy indicated that the AgNPs, ranging in size from 10 to 40 nm, exhibited a spherical morphology. Fourier-transform infrared analysis validated the abilty of A. manshuriensis extract components to serve as both reducing and capping agents for metal ions. In the context of cytotoxicity on embryonic fibroblast (NIH 3T3) and mouse neuroblastoma (N2A) cells, AgNPs demonstrated varying effects. Specifically, nanoparticles derived from callus cultures exhibited an IC50 of 2.8 µg/mL, effectively inhibiting N2A growth, whereas AgNPs sourced from hairy roots only achieved this only at concentrations of 50 µg/mL and above. Notably, all studied AgNPs’ treatment-induced cytotoxicity in fibroblast cells, yielding IC50 values ranging from 7.2 to 36.3 µg/mL. Furthermore, the findings unveiled the efficacy of the synthesized AgNPs against pathogenic microorganisms impacting both plants and animals, including Agrobacterium rhizogenes, A. tumefaciens, Bacillus subtilis, and Escherichia coli. These findings underscore the effectiveness of biotechnological methodologies in offering advanced and enhanced green nanotechnology alternatives for generating nanoparticles with applications in combating cancer and infectious disorders.
Manganese-Implanted Titanium Modulates the Crosstalk between Bone Marrow Mesenchymal Stem Cells and Macrophages to Improve Osteogenesis
Authors: Ye Kuicai , Zhang Xianming , Shangguan Li , Liu Xingdan , Nie Xiaoshuang , Qiao Yuqin
Published: September 2023

Manganese (Mn) is an essential micronutrient in various physiological processes, but its functions in bone metabolism remain undefined. This is partly due to the interplay between immune and bone cells because Mn plays a central role in the immune system. In this study, we utilized the plasma immersion ion implantation and deposition (PIII&D) technique to introduce Mn onto the titanium surface. The results demonstrated that Mn-implanted surfaces stimulated the shift of macrophages toward the M1 phenotype and had minimal effects on the osteogenic differentiation of mouse bone marrow mesenchymal stem cells (mBMSCs) under mono-culture conditions. However, they promoted the M2 polarization of macrophages and improved the osteogenic activities of mBMSCs under co-culture conditions, indicating the importance of the crosstalk between mBMSCs and macrophages mediated by Mn in osteogenic activities. This study provides a positive incentive for the application of Mn in the field of osteoimmunology.
Machine-Learning-Based Thermal Conductivity Prediction for Additively Manufactured Alloys
Authors: Bhandari Uttam , Chen Yehong , Ding Huan , Zeng Congyuan , Emanet Selami , Gradl Paul R. , Guo Shengmin
Published: September 2023

Thermal conductivity (TC) is greatly influenced by the working temperature, microstructures, thermal processing (heat treatment) history and the composition of alloys. Due to computational costs and lengthy experimental procedures, obtaining the thermal conductivity for novel alloys, particularly parts made with additive manufacturing, is difficult and it is almost impossible to optimize the compositional space for an absolute targeted value of thermal conductivity. To address these difficulties, a machine learning method is explored to predict the TC of additive manufactured alloys. To accomplish this, an extensive thermal conductivity dataset for additively manufactured alloys was generated for several AM alloy families (nickel, copper, iron, cobalt-based) over various temperatures (300–1273 K). This unique dataset was used in training and validating machine learning models. Among the five different regression machine learning models trained with the dataset, extreme gradient boosting performs the best as compared with other models with an R2 score of 0.99. Furthermore, the accuracy of this model was tested using Inconel 718 and GRCop-42 fabricated with laser powder bed fusion-based additive manufacture, which have never been observed by the extreme gradient boosting model, and a good match between the experimental results and machine learning prediction was observed. The average mean error in predicting the thermal conductivity of Inconel 718 and GRCop-42 at different temperatures was 3.9% and 2.08%, respectively. This paper demonstrates that the thermal conductivity of novel AM alloys could be predicted quickly based on the dataset and the ML model.
Research on Ship Trajectory Prediction Method Based on Difference Long Short-Term Memory
Authors: Tian Xiaobin , Suo Yongfeng
Published: September 2023

This study proposes a solution to the problem of inaccurate and time-consuming ship trajectory prediction caused by frequent ship maneuvering in complex waterways. The proposed solution is a ship trajectory prediction model that uses a difference long short-term memory neural network (D-LSTM). To improve prediction performance and reduce time dependence, the model combines the other variables of dynamic time features in the ship’s Automatic Identification System (AIS) data with nonlinear elements in the sequence data. The effectiveness of this method is demonstrated by comparing its accuracy to other commonly used time series modeling techniques. The results show that the proposed model significantly reduces training time and improves prediction accuracy.
Collaborative Framework for Underwater Object Detection via Joint Image Enhancement and Super-Resolution
Authors: Ji Xun , Liu Guo-Peng , Cai Cheng-Tao
Published: September 2023

Underwater object detection (UOD) has attracted widespread attention, being of great significance for marine resource management, underwater security and defense, underwater infrastructure inspection, etc. However, high-quality UOD tasks often encounter challenges such as image quality degradation, complex backgrounds, and occlusions between objects at different scales. This paper presents a collaborative framework for UOD via joint image enhancement and super-resolution to address the above problems. Specifically, a joint-oriented framework is constructed incorporating underwater image enhancement and super-resolution techniques. The proposed framework is capable of generating a detection-favoring appearance to provide more visual cues for UOD tasks. Furthermore, a plug-and-play self-attention mechanism, termed multihead blurpooling fusion network (MBFNet), is developed to capture sufficient contextual information by focusing on the dependencies between multiscale feature maps, so that the UOD performance of our proposed framework can be further facilitated. A comparative study on the popular URPC2020 and Brackish datasets demonstrates the superior performance of our proposed collaborative framework, and the ablation study also validates the effectiveness of each component within the framework.
Feasibility Assessment of Alternative Clean Power Systems onboard Passenger Short-Distance Ferry
Authors: Elkafas Ahmed G. , Rivarolo Massimo , Barberis Stefano , Massardo Aristide F.
Published: September 2023

In order to promote low-carbon fuels such as hydrogen to decarbonize the maritime sector, it is crucial to promote clean fuels and zero-emission propulsion systems in demonstrative projects and to showcase innovative technologies such as fuel cells in vessels operating in local public transport that could increase general audience acceptability thanks to their showcase potential. In this study, a short sea journey ferry used in the port of Genova as a public transport vehicle is analyzed to evaluate a ”zero emission propulsion” retrofitting process. In the paper, different types of solutions (batteries, proton exchange membrane fuel cell (PEMFC), solid oxide fuel cell (SOFC)) and fuels (hydrogen, ammonia, natural gas, and methanol) are investigated to identify the most feasible technology to be implemented onboard according to different aspects: ferry daily journey and scheduling, available volumes and spaces, propulsion power needs, energy storage/fuel tank capacity needed, economics, etc. The paper presents a multi-aspect analysis that resulted in the identification of the hydrogen-powered PEMFC as the best clean power system to guarantee, for this specific case study, a suitable retrofitting of the vessel that could guarantee a zero-emission journey.
ASVMR: Adaptive Support-Vector-Machine-Based Routing Protocol in the Underwater Acoustic Sensor Network for Smart Ocean
Authors: Zhang Shuyun , Chen Huifang , Xie Lei
Published: September 2023

The underwater acoustic sensor network (UASN) plays a crucial role in collecting real-time data from remote areas of the ocean. However, the deployment of UASN poses significant challenges due to the demanding environmental conditions and the considerable expenses associated with its implementation. Therefore, it is essential to design an appropriate routing protocol to effectively address the issues of packet delivery delay, routing void, and energy consumption. In this paper, an adaptive support vector machine (SVM)-based routing (ASVMR) protocol is proposed for the UASN to minimize end-to-end delay and prolong the network lifetime. The proposed protocol employs a distributed routing approach that dynamically optimizes the routing path in real time by considering four types of node state information. Moreover, the ASVMR protocol establishes a “routing vector” spanning from the current node to the sink node and selects a suitable pipe radius according to the packet delivery ratio (PDR). In addition, the ASVMR protocol incorporates future states of sensor nodes into the decision-making process, along with the adoption of a waiting time mechanism and routing void recovery mechanism. Extensive simulation results demonstrate that the proposed ASVMR protocol performs well in terms of the PDR, the hop count, the end-to-end delay, and the energy efficiency in dynamic underwater environments.
On the Effect of Horizontal Refraction Caused by an Anticyclonic Eddy in the Case of Long-Range Sound Propagation in the Sea of Japan
Authors: Sorokin Mikhail , Petrov Pavel , Budyansky Maxim , Fayman Pavel , Didov Aleksandr , Golov Aleksandr , Morgunov Yuri
Published: September 2023

The precision of acoustic ranging and navigation depends on the accuracy of the information about the sound speed field in the area of interest. Large-scale inhomogeneities in the bottom relief and water column can significantly affect the horizontal rays corresponding to vertical modes (in the framework of Burridge–Weinberg formalism), which can lead to delays in the acoustic signal modal components, as compared to propagation along the geodesics on the Earth’s surface. In this study, the influence of horizontal refraction on the delay times of the modal components is considered. In particular, it is studied to what extent the presence of a synoptic eddy near the source–receiver path increases the effective propagation distances due to horizontal refraction. The elongation of horizontal eigenrays relative to the geodesic connecting the source and the receiver is also estimated. The influence of hydrological inhomogeneities on the propagation time of different modal components of a broadband acoustic signal is investigated. This is accomplished by the integration of the group slowness (reciprocal to the group speed) along the horizontal eigenrays connecting the locations of the source and the receiver. Implications for improving the accuracy of the solution of acoustic ranging problems are discussed.
Armillaria altimontana in North America: Biology and Ecology
Authors: Kim Mee-Sook , Hanna John W. , McDonald Geral I. , Klopfenstein Ned B.
Published: September 2023

Armillaria altimontana is a fungus (Basidiomycota, Agaricomycetes, Agaricales, and Physalacriaceae) that is generally considered as a weak/opportunistic pathogen or saprophyte on many tree hosts. It widely occurs across the northwestern USA to southern British Columbia, Canada, but relatively little is known about its ecological role in the diverse forest ecosystems where it occurs. This review summarizes the biology and ecology of A. altimontana, including its identification, life cycle, distribution, host associations, and bioclimatic models under climate change.
Blockchain in the Smart City and Its Financial Sustainability from a Stakeholder’s Perspective
Authors: Hassani Hossein , Avdiu Kujtim , Unger Stephan , Mazinani Maedeh Taj
Published: September 2023

In this paper, we take a city’s budget, which represents the resources that need to be allocated, and test how many blockchain users need to join a voting process of how the city’s resources should be allocated in order to best represent their preferences. This voting process can be tracked very well through the utilization of IoT and smart technology in a smart city. Therefore, we showed that the budget resource allocation of a smart city can be significantly optimized through the utilization of blockchain technology. We found that just a tiny fraction of 0.12% of the population of blockchain participants is needed to significantly represent the spending behavior of the total population. This has significant implications as it shows the strength and importance of a required blockchain in a smart city and its minimal energy consumption requirements.
Rethinking the Impact of Land Certification on Tenure Security, Land Disputes, Land Management, and Agricultural Production: Insights from South Wello, Ethiopia
Authors: Tesfaye Bichaye , Lengoiboni Monica , Zevenbergen Jaap , Simane Belay
Published: September 2023

Land is a precious resource in the Ethiopian highlands, where the entire agricultural system depends on rain-fed system. The resource faces multiple interconnected environmental and socioeconomic challenges. Among these, the absence of tenure security has significantly affected farmers’ willingness to adopt soil and water conservation practices (SWCPs), leading to a decline in land productivity, hindering household food security, and contributing to an increase in land-related disputes. Bearing this in mind, the government of Ethiopia (GoE) has undertaken two rounds of land certification programs in selected regions, one of which was Amhara National Regional State (ANRS). This study examined how land certification strengthens tenure security, lowers land-related disputes, motivates farmers to employ SWCPs, and raises the productivity of farm plots in Dessie Zuria and Kutaber Woredas. The research followed an exploratory survey method which utilized both qualitative and quantitative data. The survey involved purposefully selected 401 household heads. Additionally, cross sectional data were collected from various sources, including Woreda and zonal agriculture, court, land, and Natural Resource Management (NRM) offices. Quantitative data were analyzed using frequency tables, percentages, graphs, figures, cross-tabulation, and descriptive statistical methods. Meanwhile, qualitative data were transcribed, grouped, and interpreted in line with the research’s objectives. SPSS software version 26 was used for data analysis. The findings denoted a positive relationship between land certification and tenure security. Furthermore, enhanced tenure security has played a positive role in reducing land-related disputes, initiating farmers to invest in SWC practices and improving the productivity of farm plots. The research suggests the adoption of a cadastral land registration system, the encouragement of community involvement, and the enforcement of laws and bylaws. The research recommend implementation of cadastral land registration system, promote community participation, and enforcement of laws and bylaws. The work has implications for development practitioners, academia and policymakers working on land tenure, SWC practices, and food security.
Spatial Correlation between Water Resources and Rural Settlements in the Yanhe Watershed Based on Bivariate Spatial Autocorrelation Methods
Authors: Zhang Lingda , Hou Quanhua , Duan Yaqiong , Liu Wenqian
Published: September 2023

The production–living–ecological functions of rural settlements are closely tied to water resources, which are the primary influencing factors of the spatial characteristics of rural settlements. However, the specific relationship between water resources and the spatial characteristics of rural settlements remains unclear. Understanding the interrelationship between the two can better safeguard the ecological pattern of the basin and optimize the living environment of settlements. This study utilized multi-source data to calculate the water yield, water demand, and ecological surplus or deficit of water resources in the Yanhe watershed. We quantified the spatial characteristics of rural settlements and employed bivariate spatial autocorrelation methods to analyze the spatial correlation between water resources and the spatial distribution, scale, and boundary form of rural settlements in the Yanhe watershed. The results show the following: ➀ Seven sub-basins in the upper reaches exhibit a severe ecological deficit in water resources, with insufficient water resources to support the demands of regional socio-economic development. The middle and lower reaches have achieved a balance between water supply and demand. ➁ Rural settlements are most densely distributed in the middle reaches, with the smallest area scale, exhibiting a transitional spatial characteristic towards the upstream and downstream ends. ➂ The Moran’s I values of spatial aggregation and morphological index of rural settlements with respect to the ecological surplus or deficit of water resources are 0.36 and 0.50, respectively, indicating a strong positive correlation. The Moran’s I value of the area scale with respect to the ecological surplus or deficit of water resources is −0.60, indicating a significant negative correlation. This research has important practical significance for guiding the spatial layout of rural settlements in the Yanhe watershed and promoting their sustainable development.
Spatial Patterns and Determinants of Bed and Breakfasts in the All-for-One Tourism Demonstration Area of China: A Perspective on Urban–Rural Differences
Authors: Sun Ao , Chen Lin , Yoshida Kunimitsu , Qu Meng
Published: September 2023

The spatial structure of Bed and Breakfast (B&B) development plays a crucial role in promoting integrated urban–rural development. However, existing B&B research has predominantly focused on single large cities, neglecting to explore the spatial patterns of B&B development and their influencing factors from the perspective of urban–rural differences. To address this gap, we conducted a comprehensive case study in an all-for-one tourism demonstration area in Hainan Province, China. We adopt geospatial analysis methods and ridge regression models to investigate the characteristics of urban–rural disparities in B&B distribution and to identify the primary factors influencing their spatial arrangement. The research findings reveal valuable insights: (1) B&B establishments in the tourism demonstration area exhibit clustering with notable variations in clustering intensity between urban and rural regions; (2) essential factors affecting the spatial distribution of B&Bs include transportation accessibility, reliance on tourism attractions, B&B development infrastructure, and the availability of living services; (3) tourism resource dependence emerges as the most significant driving force behind B&B agglomerations in the tourism demonstration area; and (4) road network density, hotel service availability, and neighborhood residential density are three additional critical factors affecting B&B distribution, with their influence varying between urban and rural B&Bs. Based on these key findings, we propose development strategies for optimizing B&Bs’ spatial structure in the tourism demonstration area and outline a blueprint for fostering integrated urban–rural development.
Investigating Adaptation to And-Coordination in English: An ERP Study
Authors: Kaan Edith
Published: September 2023

According to certain approaches to adaptation, readers and listeners quickly adjust their processing of sentences to match properties of recently encountered sentences. The present preregistered study used ERP (event-related brain potentials) to investigate how and when readers change their processing in response to recent exposure to sentences of a particular structure. We presented English speakers (n = 36) with three virtual blocks of English sentences with and-coordination ambiguities. In the first and third block, the ambiguity was always resolved towards a noun phrase (NP-) coordination; in the second block, the structure was always a clausal (S-) coordination. We manipulated the plausibility of the critical noun after the conjunct. N400 and P600 plausibility effects were probed to see to what extent the reader preferred an NP- coordination or expected the sentence to continue differently. Our results suggest that readers change their processing as a function of recent exposure but that they do not immediately adapt to the target structure. Furthermore, we observed substantial individual variation in the type and change in response over the course of the study. The idea that structural adaptation is immediate and a direct reflection of the properties of the recent context therefore needs to be fine-tuned.
Passive Surveillance of SARS-CoV-2 in Adult Blacklegged Ticks (Ixodes scapularis) from Northeast Pennsylvania
Authors: Hunt Erin A. , Schwartz Sarah , Chinnici Nicole
Published: September 2023

Monitoring the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in wildlife is vital to public health. White-tailed deer (Odocoileus virginianus) in the United States have tested positive for SARS-CoV-2, and their interactions with blacklegged ticks (Ixodes scapularis) raise the question of whether or not these ticks also carry SARS-CoV-2. In this study, 449 blacklegged ticks from Northeast Pennsylvania were collected in the fall of 2022 and tested via RT-qPCR for the presence of SARS-CoV-2. Fourteen ticks were amplified with late quantification cycles (Cq) using primers from two nucleocapsid genes (N1 and N2) via TaqMan assays. Three of these samples were amplified on a SYBR green assay during secondary testing. However, melt curve and gel electrophoresis analysis verified negative results for these three samples. Genetic sequencing was performed on one of the three samples to look for potential cross-reactions causing the amplification observed. However, no significant match was found in the NCBI database. Although all 449 blacklegged ticks were negative for SARS-CoV-2, I. scapularis should continue to be tested for COVID-19. If blacklegged ticks test positive for COVID-19 in the future, research should focus on determining the stability of SARS-CoV-2 with the tick vector and the potential for transmission through tick bites.
mRNA Abundance of Neurogenic Factors Correlates with Hearing Capacity in Auditory Brainstem Nuclei of the Rat
Authors: Engert Jonas , Doll Julia , Vona Barbara , Ehret Kasemo Totta , Spahn Bjoern , Hagen Rudolf , Rak Kristen , Voelker Johannes
Published: September 2023

Neural stem cells (NSCs) have previously been described up to the adult stage in the rat cochlear nucleus (CN). A decreasing neurogenic potential was observed with critical changes around hearing onset. A better understanding of molecular factors affecting NSCs and neurogenesis is of interest as they represent potential targets to treat the cause of neurologically based hearing disorders. The role of genes affecting NSC development and neurogenesis in CN over time on hearing capacity has remained unclear. This study investigated the mRNA abundance of genes influencing NSCs and neurogenesis in rats’ CN over time. The CN of rats on postnatal days 6, 12, and 24 were examined. Real-time quantitative polymerase chain reaction arrays were used to compare mRNA levels of 84 genes relevant to NSCs and neurogenesis. Age- and hearing-specific patterns of changes in mRNA abundance of neurogenically relevant genes were detected in the rat CN. Additionally, crucial neurogenic factors with significant and relevant influence on neurogenesis were identified. The results of this work should contribute to a better understanding of the molecular mechanisms underlying the neurogenesis of the auditory pathway.