bluuebunny/crossref_metadata_2025 huggingface dataset:
Educator Advocacy for Queer Students in Schools
Authors: Quantz Mary
Published: March 2021

In this Dialogues we are highlighting educators, community members, and researchers whose work focuses on advocacy for lesbian, gay, bisexual, transgender, and queer or questioning (LGBTQ+) students in educational institutions. Despite greater visibility, more legal protections, and seemingly greater support for LGBTQ+ individuals, LGBTQ+ students in K-12 schools still face hostile school environments with little to no representation in school curricula. The Gay, Lesbian and Straight Education Network’s most recent school climate report found that over half the LGBTQ+, or queer, students surveyed reported facing regular bullying and harassment. Additionally, trans and gender nonconforming students, and transgender people in the United States at large, face threats to their rights under the Trump presidency.
Advocating for LGBTQ+ Students with Disabilities
Authors: Gothberg June , Roberts LaSonja , Ebejer Mary
Published: March 2021

Much of education research in recent years has focused on how the bullying and victimization of LGBTQ+ students and youth with disabilities (YWD) can lead to increased challenges and limited opportunities later in life. However, few studies have focused on how bullying and victimization affects students who both have disabilities and identify as LGBTQ+ or on how specific practices could improve both their experiences in school and their success later in life. YWD face the same challenges when it comes to puberty, social identity, and planning for adult roles as their non-disabled peers, but they are more likely to struggle with developing their identity and thinking about their future, particularly if they identify as LGBTQ+, which is why educators and parents must work together to advocate for changes that promote an inclusive, safe, and just environment for all students. In this article, we offer guidance using evidence-based promising practices (EBPPs) to improve educational settings for LGBTQ+ YWD that is informed by our work at the state, local, and classroom levels. Gran parte de las investigaciones en educación en los últimos años se han enfocado en como el acoso y la victimización de los estudiantes LGBTQ+ y estudiantes con discapacidades pueden llevarlos a un aumento de desafíos y menos oportunidades más tarde en sus vidas. Sin embargo, pocas investigaciones se han enfocado en como el acoso y la victimización afecta a los estudiantes con discapacidades o identificados como LGBTQ+ o en como prácticas específicas pueden mejorar sus experiencias escolares y a la vez su éxito en el futuro. Los estudiantes con discapacidades enfrentan los mismo retos que sus compañeros sin discapacidades cuando se trata de la pubertad, identidad social, y en planear para su rol como adultos, pero tienen más dificultad en luchar con el desarrollo de su identidad y en pensar en su futuro, especialmente si se identifican como LGBTQ+, por lo tanto es importante que los docentes y padres de familia trabajen juntos para abogar para cambios que promuevan un ambiente inclusivo, seguro, y justo para todos los estudiantes. En este artículo, ofrecemos consejos utilizando prácticas prometedoras basadas en evidencias para mejorar el ambiente educativo para estudiantes LGBTQ+ con discapacidades que están informadas en nuestro trabajo al nivel estatal, local y de aula.
不锈钢矩形管轴心受压构件弹性屈曲板组相关性研究
Authors: 梁 勇 , 李 少华
Published: March 2021

文章以截面形状系数、板件高厚比为主要参数，研究了冷成型不锈钢矩形管轴心受压构件弹性屈曲时板组相关性能。首先利用有限元软件Abaqus对直角矩形管轴心受压构件进行弹性屈曲分析，得到截面板件的弹性屈曲系数的建议公式。然后通过对计算数据进行分析来讨论截面形状系数和板件高厚比与弹性系数的关系。
垃圾压缩设备远程监控系统设计与试验
Authors: 于 晓娟 , 陈 锐 , 姚 燕生 , 郑 磊 , 姚 宝珍
Published: March 2021

为保障城市人民生活正常运行，需要垃圾处理站的压缩设备在恶劣的工况下高负载长时间工作，所以发生故障的概率也大大增加。为解决这一问题，对垃圾压缩设备进行了远程监控系统的设计与试验，应用结果表明该系统可实时监测设备的运行状况，快速解决设备运行中发生的故障，产生良好的经济效益。
建筑设计中绿色建筑设计理念的整合探究
Authors: 赵 祥
Published: March 2021

近些年伴随着人们环保意识的不断增加，国家对环境的重视程度也是越来越重视，可持续发展的理念已经在各行各业中广泛传播，并且逐渐成为各个行业发展的主要趋势。对于建筑行业来说更是如此，传统的建筑行业对环境的影响非常大，在施工过程中不仅对土地产生了污染，而且还对周围的自然环境造成了破坏，而且噪音问题也对人们的健康产生了很大的威胁，因此在建筑行业中深入推广环保绿化理念是势在必行的，是建筑行业不断发展的方向和动力。全面利用绿色环保设计理念来进行建筑设计，是建筑行业新的发展方向。因此在文中我们主要对建筑设计中绿色设计理念的整合进行详细的分析与探讨，以供参考。
民航空管系统空中交通管理生产数据中心建设研究
Authors: 幸 成龙
Published: March 2021

近年来，随着我国民用航空事业的不断发展，航空运输量不断增长。信息化技术为民用航空发展提供了强有力的技术支撑，民航系统各单位也积极投身数据中心建设中，希望通过构建数据中心，强化空中交通管理数据共享机制，提升民航业务及服务的数字化水平，为行业内外提供更加准确、及时和全面的民航服务信息。文章基于民航空管系统空中交通生产数据中心建设，提出现状分析及规划，研究基于云架构的数据中心设计。
公路沥青路面施工现场试验检测技术探讨
Authors: 张 爱春
Published: March 2021

在公路施工的过程中，因为沥青和其他材料相比具有适用性而且寿命较长，所以获得了普遍使用。但沥青路面同样也会遇到较多的质量问题，比如环境和温度的影响。就要求相关工作人员在施工过程中严格的根据设计规范进行施工，并且利用施工现场中的试验检测技术针对工程的整体质量展开相应的监测和分析。文章根据相关例子介绍了公路工程沥青路面质量的具体需求，普遍使用的施工现场相关检测技术，从而大大提升沥青路面的整体质量以及效率。
建筑工程质量监督管理工作中存在的问题与对策
Authors: 田 卫忠
Published: March 2021

在社会经济快速发展的影响下，我国各个领域都得到了全面的发展进步，为整个建筑工程行业的发展壮大带来了诸多的机遇，在这种发现形势下人们对于建筑工程质量监督管理工作越发的重视。建筑工程质量监督管理工作最为主要的作用就是确保建筑工程各项施工工作都能够按照规范标准落实，从根本上保证整个建筑工程的施工质量。所以，在实际组织开展建筑工程监督管理工作的时候，工作人员应当全面的掌握施工标准，并加大力度推进质量监督工作的实施，充分结合各方面实际情况对建筑工程质量管理工作机制进行优化和创新，不断增强建筑施工单位的综合实力，为整个建筑工程行业的未来稳步发展打下坚实的基础。
市政公用工程质量控制和管理研究
Authors: 罗 文
Published: March 2021

在社会快速发展的带动下，民众的生活水平得到了显著的提升，并且也为各个行业的发展壮大带来了良好的机遇。就市政公用工程来说其在城市建设中的作用是非常巨大的，针对市政公用工程施工质量进行控制和管理，严格遵从相关行政机构制定的建筑工程标准落实各项施工工作，切实的对施工工作规范性和标准性加以保证。但是就当前我国市政公用工程质量实际情况来说，整体水平较差，其中还存在诸多的问题需要加以根本的解决。在实际组织实施市政公用工程施工工作的时候，往往会受到外界多方面因素的影响，所以极易发生危险事故，最终会对工程施工质量和施工效率都会产生不良影响。鉴于此，这篇文章主要围绕市政公用工程质量控制和管理研究工作展开全面深入的研究分析，希望能够对我国城市建设工作的良好发展有所帮助。
某特勤消防站设计方案探讨
Authors: 郭 术春
Published: March 2021

特勤消防站是承担特种灾害事故应急救援和特殊火灾扑救任务、同时又可以承担其辖区内的普通消防站任务的城市公共基础设施，本项目为该区域的消防设施建设提供了完美的解决方案，该消防站的建设也增强了该区域的消防救援战斗力。
5G通信传输网络的建设策略探析
Authors: 焦 天羽 , 韩 章杰
Published: March 2021

相比于传统的3G、4G网络通信模式，5G技术有着更高的信息传输速率。近些年我国5G技术经过不断地研究改进开始逐渐出现在大众视野中，并且已经在部分领域投入使用。当前我国5G通信技术仍然处于发展初期，在具体应用过程中仍然存在诸多不足。在未来需要加强规划和研究5G技术的建设局限性并且不断改进优化，推动5G技术的可持续发展。为此，需要在明确5G技术概念和特点的基础上，就5G通信技术中包含的主要技术进行分析总结，优化革新5G通信传输网络构建，推动该技术进一步推广和应用。
浅谈普通国省干线公路安全隐患排查治理思路
Authors: 崔 启悦
Published: March 2021

随着我国国省干线公路的不断增多，安全问题日益凸显。我国的普通国省干线公路在交通运输方面发挥着重要作用，为我国的经济发展做出了重要作用，在交通运输体系中不可或缺。基于此，该研究对普通国省干线公路安全隐患的排查及治理工作进行了探讨，以期提升公路工程运营安全。
浅谈公路工程施工技术的改革措施
Authors: 李 乾成
Published: March 2021

我国的经济建设发展至今已取得了万众瞩目的成果，使公路的建设能够更有序的建设。经济的发展因为有人力和财力的流动性得到了保障，使各个地区都可以平衡的发展，为此做了有力的保障，并且还促进了各个行业的发展。在我国公路发展的过程中，对施工技术的有效运用提高了公路建设的水平，加快了现代化的步伐。本篇文章主要是从公路施工技术的控制与管理探讨了改革优化措施，为同行业提供参考。
机电一体化技术在智能制造中的实践研究
Authors: 王 卫平
Published: March 2021

伴随经济的迅速发展，智能制造业在经济发展过程中所发挥的作用越来越重要，其地位也变得分外重要，而这样对行业内部从业者所提出的标准和要求就更加严格，要求其不断的提高自身的专业技术水平和综合素质才能更加准确的把握智能制造业行业发展的特点和机电一体化技术，才能更好的促进机电一体化技术在智能制造业中得到更好的发展。
基于物联网的智慧物业管理服务模式探究
Authors: 冯 敬
Published: March 2021

中国城市化进程推动了智慧城市建设的积极发展。早在2014年国务院就发布了《国家新型城镇化规划（2014-2020年）》，明确了智慧城市建设的内容。财富管理行业是城市管理的重要组成部分，智慧城市的发展促进了智慧财富管理服务的发展。在文章中，我们将详细分析IoT环境中智能资产的含义以及智能资产管理服务模式的框架，并探讨IoT环境中智能资产管理服务模式的具体应用方法。
Acknowledgement to Reviewers of Maritime Technology and Research in 2020
Authors: Office MTR Editorial
Published: March 2021

The editorial team greatly appreciates the reviewers who have dedicated their considerable time and expertise to the journal’s rigorous editorial process in 2020, regardless of whether the submissions were finally published or not. In 2020, a total of 45 articles were submitted to the journal, with a median time to first decision of 50 days, and 71 days from submission to publication. The editorial team would like to express their sincere gratitude to the following reviewers for their generous contribution in 2020:

Agnieszka Lazarowska, Poland

Akihiko Matsuda, Japan

Aldo Chircop, Canada

Anand Kumar, Malaysia

Anastasia Christodoulou, Sweden

Anthony Paul Sison Guerrero, United States

Anthony Yaw Karikari, Ghana

Arunachalam Ponshanmugakumar, India

Asen Asenov, Bulgaria

Birgit Pauksztat, Sweden

Boris Svilicic, Croatia

Carlos Efrén Mora Luis, Spain

Chalermpong Senarak, Thailand

Chandrashekher Umanath Rivonker, India

Che Abd Rahim Mohamed, Malaysia

Christiaan Adika Adenya, Kenya

Christopher Nolan, United States

Dimitrios Dalaklis, Sweden

Dong-Taur Su, Taiwan

Ergun Demirel, Turkey

Fatima Zohra Bouthir, Morocco

Florin Rusca, Romania

Floris Goerlandt, Canada

Fu Ming Tzu, Taiwan

Geng-Ruei Chang, Taiwan

George H. Kaplan, United States

Giulio Dubbioso, Italy

Hao Long, China

Hong Oanh Owen Nguyen, Australia

Jacopo Aguzzi, Spain

Jagan Jeevan, Malaysia

Jerónimo Esteve-Perez, Spain

Jiangang Jin, China

Jianjun Wu, China

Jianmin Li, China

Jiao Jialong, China

Juan Carlos Astudillo, Hong Kong

Jun Ando, Japan

Kantapon Tanakitkorn, Thailand

Kwan Ouyang  Taiwan

Laura Piñeiro, Spain

Li Ye, China

Lidong Fan, Australia

M. P. R Prasad, India

Maciej Reichel, Poland

Mahinda Bandara, Sri Lanka

María-Araceli Losey-Leon, Spain

Marta Mańkowska, Poland

Maruj Limpawattana, Thailand

Masayoshi Doi, Japan

Mate J. Csorb, Norway

Ming-Cheng Tsou, Taiwan

Mohammed Russtam Suhrab Ismail, Malaysia

Mohd Hazmi Bin Mohd Rusli, Malaysia

Moses Kopong Tokan, Indonesia

Mumini Dzoga, Kenya

Neil J. Douglas, New Zealand

Nucharee Nuchkoom Smith, Thailand

Oghenetejiri Digun-Aweto, South Africa

Olabisi Michael Olapoju, Nigeria

Olaf Chresten Jensen, Denmark

Om Prakash Sha, India

Paul Tae-Woo Lee, China

Pengfei Zhang, United Kindom

Peter RANERI, Sweden

Peter Ralph Galicia, Philippines

Phansak Iamraksa, Thailand

Phatchara Sriphrabu, Thailand

Proshanto Mukherjee, China

Saikat Banerjee, India

Sarinya Sanitwong Na Ayutthaya, Thailand

Seonho Cho, Korea

Sheree-Ann Adams, Grenada

Supawat Chaikasem, Thailand

Surasak Phoemsapthawee, Thailand

Suresh Bhardwaj, India

Thee Chowwanonthapunya, Thailand

Vasilios D. Tsoukalas, Greece

Wirachaya Chanpuypetch, Thailand

Yodchai Tiaple, Thailand

Yottana Khunatorn, Thailand
The Influence of Media on the State Supervision System
Authors: Muhammad Abrar Azizi
Published: March 2021

Dayah is the oldest dakwah development institution in the archipelago, which emphasizes the formation of community morals to be civilized and polite. At first the dayah was not only a place for community religious learning, but also as a school institution to study general education, but when colonialism took place in this country, education was divided into two categories, namely religion and general. From then on, the effect of the decline in dayah education occurred, so that the interest of the community to study in the dayah was reduced and the function of the dayah began to change from its existence. Dayah institutions exist in society, and are community-owned educational institutions, which are built and developed by the community themselves independently. Dayah institutions are still consistent with religious education, so that this becomes a distinctive feature for dayah which is different from other educational institutions. Dayah has a special education system and pattern that is arranged in the form of a curriculum that is taught to its students. This learning pattern aims to be able to give birth to future generations who have strong faith and have broad insight.
Mural Hunter: una app de catalogación y diálogo en torno al patrimonio artístico urbano
Authors: Navarro Neri Iñaki
Published: March 2021

¿Puede el arte mural urbano ser un espacio para el diálogo en torno al patrimonio? Desde el proyecto de ciencia ciudadana CIVITAS 2.0: espacio abierto para la educación patrimonial se creó hace ya unos años la app para dispositivos móviles. MURAL HUNTER es una app de geolocalización y catalogación de arte mural urbano que permite el diálogo en torno a una captura de arte mural. El trabajo continuo por parte de los y las internautas ha posibilitado el surgimiento de una cibercomunidad activa que comparte y dialoga sobre temas como el arte mural urbano y la educación patrimonial.
IV/X. YÜZYILA KADAR HORASAN VE MÂVERÂÜNNEHİR’DE EHL-İ HADÎS-HANEFÎLİK İLİŞKİSİ
Authors: ATEŞYÜREK Ahmet
Published: March 2021

Bu araştırma, mezhebi aidiyetlerin oluşmaya başladığı II/VIII. yüzyılın ortasından başlayarak IV/X. yüzyıla kadar devam eden süreçte Horasan ve Mâverâünnehir’deki Ehl-i Hadîs ile Hanefîlik arasındaki ilişkiyi ortaya koymayı amaçlamaktadır. Bölgenin gündemi, tıpkı fetih sürecinde olduğu gibi, Abbasîler döneminde de Bağdat’ın gündeminden farklı değildi. İki zıt anlayışın Horasan’daki söz konusu mücadelesi, Me’mun ve ardından Tâhirîler döneminde kendini iyice belli etmiştir. Merkeze uzak Mâverâünnehir söz konusu olduğunda, Ehl-i Hadîs’in varlığına dair kapsayıcı bilgilere ulaşmak zordur. Yine de eldeki bilgiler bize, bölgedeki güç mücadelesinde dengenin Belh’li ve Mâverâünnehir’li Hanefîler lehinde olduğunu göstermektedir. Bölge Hanefîlerinin temsili, II/VIII. yüzyılın sonundan itibaren Ehl-i Hadîs’ten çok daha güçlü olmuştur. IV/X. yüzyıla gelindiğinde ise tablonun Ehl-i Hadîs-Hanefîlik mücadelesinden Şâfiîlik-Hanefîlik mücadelesine evrildiği müşahede edilmektedir. Mâtürîdî’nin yaşadığı dönemin sonlarında artık Semerkant’ta birçok Şâfiî medrese eğitim vermeye başlamıştır. Şâfiî mezhebinin Mâverâünnehir’de Hanefîler için zorlu bir rakip haline gelişi, Mâtürîdî’nin Te’vîlâtü’l-Kurân adlı eserinde yaptığı Şâfiî eleştirilerinden de anlaşılmaktadır.
Sintomas de stress e estratégias de coping em professores moçambicanos do ensino superior
Authors: Humberto Samira Carlos , Abacar Mussa , Aliante Gildo
Published: March 2021

A docência tem sido considerada altamente estressante diante dos vários desafios relativos à sua profissão. Este trabalho teve por objetivo avaliar os sintomas de stress e estratégias de coping em professores universitários de uma instituição pública de ensino superior em Moçambique. A pesquisa é de natureza quantitativa, do tipo descritivo e teve uma amostra de 100 professores, sendo 58% do sexo masculino e 42% do sexo feminino. A coleta de dados deu-se por meio de três instrumentos: Inventário de Sintomas de Stress para Adultos de Lipp (ISSL-Lipp), versão reduzida de Coping Orientation to Problems Experienced Inventory (Brief-COPE) e questionário sobre os dados sociodemográficos e laborais. A análise estatística dos dados com auxílio de Statistical Packege for the Social Sciences (SPSS) indicou que a maioria dos professores pesquisados apresentou sintomas de stress na fase de alerta e de resistência, com predominância de sintomas psicológicos. E em situações de stress os professores privilegiam o uso de estratégias de coping focadas no problema e na emoção. Destaca-se a necessidade da realização de futuros estudos visando identificar as consequências e fontes de stress ocupacional nos professores para propor estratégias de prevenção e intervenção mais adequadas.
Condições climáticas na incidência de cercosporiose (Cercospora coffeicola) e bicho-mineiro (Leucoptera coffeella) em cultivares de cafeeiros em Monte Carmelo, Minas Gerais, Brasil
Authors: Nascentes Taynara Faria , Nascimento Letícia Gonçalves do , Fernandes Marco Iony dos Santos , Dutra Winícius Baquião , Carvalho Fábio Janoni , Andaló Vanessa , Gallet Deyvid da Silva , Dias Werik Pereira , Assis Gleice Aparecida de
Published: March 2021

O material genético adaptado às condições do Cerrado Mineiro e o monitoramento pode ser um fator determinante para o manejo eficiente de pragas e doenças do cafeeiro.  Neste contexto, objetivou-se avaliar as condições climáticas na incidência de cercosporiose e bicho-mineiro em cultivares de cafeeiros na região de Monte Carmelo, Minas Gerais. O experimento foi conduzido na Universidade Federal de Uberlândia, Campus Monte Carmelo. O delineamento experimental utilizado foi em blocos casualizados, com quatro blocos, e os tratamentos foram constituídos por oito cultivares de Coffea arabica L.: Acaiá Cerrado MG-1474; Mundo Novo IAC 379-19; Bourbon Amarelo IAC J10; Catuaí Vermelho IAC 99; Paraíso MG H 419-1; Topázio MG-1190; Acauã Novo e IAC 125 RN. Cada parcela experimental foi constituída por 10 plantas, sendo avaliadas as cinco plantas centrais. Foi avaliada mensalmente a presença de lesões de cercosporiose no ramo localizado no terço superior pelo método não destrutivo. Foram contabilizadas quinzenalmente o número de folhas com minas intactas de bicho-mineiro no ramo plagiotrópico selecionado no terço médio. A incidência de cercosporiose e bicho-mineiro foi avaliada no período entre dezembro de 2017 a agosto de 2018. As cultivares que apresentaram menor incidência de bicho-mineiro foram Mundo Novo IAC 379-19, Acaiá Cerrado MG-1474, Bourbon Amarelo IAC J10, Paraíso MG H 419-1 e Topázio MG-1190, respectivamente. A maior incidência de bicho-mineiro ocorreu no período de abril até agosto. Os meses que apresentaram maior incidência de cercosporiose foram de dezembro a maio, havendo variabilidade da ocorrência da doença entre as cultivares testadas.
Equilíbrio postural em idosos com e sem Diabetes Mellitus tipo 2: Uma análise comparativa
Authors: Dias Vanessa da Nóbrega , Jacome Maria Clara Almeida , Meneses Wesley Ribeiro Costa , Carlos Adriana Guedes , Gazzola Juliana Maria
Published: March 2021

O presente estudo teve como objetivo investigar o equilíbrio postural das pessoas idosas com e sem Diabetes Mellitus tipo 2 (DM2) e verificar as características clínicas associadas. Trata-se de um estudo observacional, analítico e transversal; avaliou-se 233 pessoas idosas (60 anos ou mais), sendo 147 com diagnóstico de DM2 (G1) e 86 sem DM2 (G2). O equilíbrio postural foi avaliado por meio do Mini - The Balance Evaluation Systems Test (MiniBESTest). As associações entre os escores totais do G1 e G2 foram verificadas por meio dos testes de Mann-Whitney e teste Qui-Quadrado, α=0,05. Após a análise inferencial, foi observada significância entre as variáveis dos grupos G1 e G2: IMC (p=0,048), número de medicamentos (p=0,001), TUGt motora (p=0,015), FPP (p<0,001), WHODAS (p=0,011), EDG (p=0,001), presença de alterações nos pés (p<0,001), calosidade (p<0,001), alterações articulares (p<0,001), alterações dermatológicas (p<0,001), sensibilidade vibratória (p<0,001), sensibilidade cutâneo-protetora (p<0,001), hipotensão ortostática (p=0,003) e medo de quedas (p=0,002). A média do MiniBesTest foi de 22,15±4,64 pontos para o grupo com DM2 e 21,94 ± 4,89 pontos para o grupo sem DM2. Foi observado também, significância nos domínios do Mini BESTest: ajustes antecipatórios (p=0,001) e respostas posturais (p=0,042) em idosos com e sem DM2. Os idosos do G1 apresentam maior prejuízo do equilíbrio postural, quando associados à presença de sintomas depressivos, diminuição da mobilidade, presença de comorbidades, polifarmácia, alterações nos pés e medo de quedas.
Do ambulante ao empreendedor: uma etnografia no comércio da comida de rua no Recôncavo da Bahia
Authors: Santana Gizane Ribeiro de , Amparo-Santos Lígia
Published: March 2021

O artigo buscou compreender o processo de transição do ambulante ao empreendedor na comida de rua, a partir de um estudo etnográfico desenvolvido junto aos trabalhadores deste comércio, na cidade de Santo Antônio de Jesus, Recôncavo da Bahia. A etnografia seguiu a linha analítico-interpretativa de Clifford Geertz. A etapa de campo durou sete meses, com uso das técnicas: observação sistemática e participante e entrevistas com ambulantes e informantes-chave. Outras fontes alternativas, como reportagens de sites e jornais locais compuseram o estudo. A análise fundamentou-se em teóricos como Ricardo Antunes, para discutir questões que acercam o trabalho informal, o vir-a-ser empreendedor e a precarização no trabalho ambulante. Verificou-se que a implementação do Programa SAJ Legal, intervenção política que visou reorganizar e reestruturar o comércio de rua na cidade, culminou na “recategorização” dos ambulantes à microempreendedores. Parte destes não reconheciam a “identidade” de MEI, forjada pelo poder público, significados revelados em micro ações, como táticas de resistência e verbalizações dissonantes, na prática do labor. O Programa revelou adotar estratégias baseadas em políticas neoliberais, ao assumir o discurso “empreendedor” para regulação, em detrimento de uma política de proteção social para esses sujeitos. Assim, a formalização do ambulante à MEI representou menos uma política resolutiva, do que repercutiu como parâmetro de higienização social e estratégia econômica. Essas manifestações denotaram que a corrosão dos direitos do trabalhador, encoberta sob o véu do discurso empresarial, atendem, prioritariamente, ao mercado financeiro e representam o contingenciamento de novas formas de exclusão e precarização dos vínculos de trabalho.
APRIORI ALGORITHM IMPLEMENTATION TO DETERMINE PURCHASE PATTERNS OF RAW MATERIALS AT PT PENJALINDO NUSANTARA
Authors: Prastyo Dedi Rozaq , Asri Sri Dianing
Published: March 2021

PT. Penjalindo Nusantara is a manufacturing company in the packaging field where production depends on customer demand or what is commonly known as job orders so that timely production work and availability of sufficient materials are mandatory for the company. There was a problem in the implementation of the raw material supply strategy by PT. Penjalindo Nusantara caused delays in the supply of raw material stocks. The solution to this problem is to apply the Apriori algorithm to find out what raw materials are being purchased simultaneously so that it can be the basis for implementing a purchasing strategy in supporting the effectiveness of procurement of raw material stocks and also saving time in sending raw materials by suppliers. This research uses a Web-based data mining application to find the raw material purchase pattern. The result of this research is obtained 11 patterns of purchasing raw materials using a minimum value of 90% support and a minimum of 100% confidence with a lift ratio of 1 as a reference for determining which raw materials will be purchased at the same time.
COMPARISON OF REGIONAL CLUSTER ANALYSIS ACCORDING TO INCLUSIVE DEVELOPMENT INDICATORS IN JAVA ISLAND 2018 BETWEEN HIERARCHICAL AND PARTITIONING CLUSTERING STRATEGIES
Authors: Fatikhurrizqi Akhmad , Wijayanto Arie Wahyu
Published: March 2021

Gross Domestic Product (GDP) is one of the most common indicators to reflect a nation’s development. Indonesia's GDP has an average growth rate of 5 percent over the 2015-2019 period with the highest growth rate occurred in 2018. Furthermore, the provinces in Java Island contributed the most out of any province to Indonesia’s GDP in that year. However, the development in Java Island still has several issues, such as high poverty, unequal income distribution, and high unemployment. This problem indicates that the economic growth in Java Island has not been inclusive concerning development. This study aims to group regencies/municipalities in Java Island based on indicators of inclusive growth. These indicators refer to McKinley (2010) in a journal published by the Asian Development Bank (ADB). The cluster methods used to represent each hierarchical and partitioning are the Agglomerative Nesting (AGNES) and K-Means methods. The results of this study show that there are 3 clusters based on the AGNES method and 4 clusters based on the K-Means method. Clusters with good inclusive growth characteristics are dominated by municipality areas based on the K-Means method. Meanwhile, the clusters with low inclusive growth characteristics are dominated by regencies/municipalities on Madura Island based on the K-Means and AGNES methods. The comparison of the appropriate methods in this study based on the silhouette value is the AGNES method.
Innovations Pour l'Assainissement Urbain: Adapter les approches pilotées par la communauté
Authors: Myers Jamie , Cavill Sue , Musyoki Samuel , Pasteur Katherine , Stevens Lucy
Published: March 2021

Innovations pour l'assainissement urbain a été rédigé en réponse aux demandes de conseils concrets émanant des praticiens sur la manière de mobiliser les communautés pour les inciter à améliorer différents maillons de la chaîne d'assainissement dans les zones urbaines.
‘Peripateticating among the mountains’: Robert Southey and the Aesthetics of Pedestrian Motion
Authors: Gonzalez Jonathan
Published: March 2021

Robert Southey's first published text about the Lake District, the faux travel narrative Letters from England (1807), inaugurated what became a lifelong concern with this landscape, one with pedestrianism at its very core. Ostensibly the work of the Spanish tourist Don Manuel Alvarez Espriella, Southey's Lakeland tour narrative depended on his own Letters Written During a Short Residence in Spain and Portugal (1797) – his Iberian countryside ramblings serving as a blueprint to frame his alter ego's engagement with the Lakes on foot. The motif of the outlandish Spaniard in the English fells as a turnaround of the foreign Englishman walking in Iberia, I argue, was exploited by Southey to outgrow the limitations of the picturesque as a mode of understanding and appreciating landscape. These two texts offer an insight into the direction of thought at work in peripatetic practice, evincing a markedly pedestrian Southeyan gaze that highlights each place's potential to hold multiple meanings.
An Isothermal Molecular Point of Care Testing for African Swine Fever Virus Using Recombinase-Aided Amplification and Lateral Flow Assay Without the Need to Extract Nucleic Acids in Blood
Authors: Zhang Yuhang , Li Qingmei , Guo Junqing , Li Dongliang , Wang Li , Wang Xun , Xing Guangxu , Deng Ruiguang , Zhang Gaiping
Published: March 2021

African swine fever (ASF) is a highly contagious and usually deadly porcine infectious disease listed as a notifiable disease by the World Organization for Animal Health (OIE). It has brought huge economic losses worldwide, especially since 2018, the first outbreak in China. As there are still no effective vaccines available to date, diagnosis of ASF is essential for its surveillance and control, especially in areas far from city with limited resources and poor settings. In this study, a sensitive, specific, rapid, and simple molecular point of care testing for African swine fever virus (ASFV) B646L gene in blood samples was established, including treatment of blood samples with simple dilution and boiling for 5 min, isothermal amplification with recombinase-aided amplification (RAA) at 37°C in a water bath for 10 min, and visual readout with lateral flow assay (LFA) at room temperature for 10–15 min. Without the need to extract viral DNA in blood samples, the intact workflow from sampling to final diagnostic decision can be completed with minimal equipment requirement in 30 min. The detection limit of RAA-LFA for synthesized B646L gene-containing plasmid was 10 copies/μl, which was 10-fold more sensitive than OIE-recommended PCR and quantitative PCR. In addition, no positive readout of RAA-LFA was observed in testing classical swine fever virus, porcine reproductive and respiratory syndrome virus, porcine epidemic diarrhea virus, pseudorabies virus and porcine circovirus 2, exhibiting good specificity. Evaluation of clinical blood samples of RAA-LFA showed 100% coincident rate with OIE-recommended PCR, in testing both extracted DNAs and treated bloods. We also found that some components in blood samples greatly inhibited PCR performance, but had little effect on RAA. Inhibitory effect can be eliminated when blood was diluted at least 32–64-fold for direct PCR, while only a 2–4 fold dilution of blood was suitable for direct RAA, indicating RAA is a better choice than PCR when blood is used as detecting sample. Taken together, we established an sensitive, specific, rapid, and simple RAA-LFA for ASFV molecular detection without the need to extract viral DNA, providing a good choice for point of care testing of ASF diagnosis in the future.
Review: The Emerging Role of Neutrophil Extracellular Traps in Sepsis and Sepsis-Associated Thrombosis
Authors: Chen Zhaoyuan , Zhang Hao , Qu Mengdi , Nan Ke , Cao Hanzhong , Cata Juan P. , Chen Wankun , Miao Changhong
Published: March 2021

Patients with sepsis commonly suffer from coagulation dysfunction and lead to the formation of thrombus. During the development of sepsis, neutrophils migrate from the circulating blood to infected tissues and mediate the formation of neutrophil extracellular traps (NETs) that kill pathogens. However, the overactivation of neutrophils can promote the formation of immunothrombosis and even cause disseminated intravascular coagulation (DIC), which damages microcirculation. The outcome of sepsis depends on early recognition and intervention, so clinical evaluation of NETs function may be a valuable biomarker for early diagnosis of sepsis. The interaction of NETs with platelets, complement, and endothelium mediates the formation of immunothrombosis in sepsis. Inhibiting the formation of NETs is also considered to be one of the potential treatments for sepsis. In this review, we will discuss the key role of neutrophils and NETs in sepsis and septic thrombosis, in order to reveal new mechanisms for thrombosis treatment of sepsis.
Comparison of Three Measurement Principles on Water Triple Oxygen Isotopologues
Authors: Ranjan Shyam , Leuenberger Markus C.
Published: March 2021

The widespread method for measuring Δ17O (17O-excess) is an offline CoF3 (Cobalt tri-fluoride) conversion of water to molecular oxygen with subsequent isotope determination by dual inlet mass spectrometry. High precisions for Δ17O measurements, using CoF3 water conversion, are so far only possible with off-line methods. Here we report on an improved and modified online continuous flow method intended for high precision triple oxygen isotope analysis. This method is improved by optimizing the reactor (site for conversion of H2O into oxygen through the chemical reaction) compositions, size of the fused silica capillary, flow regulator, and data treatment. Our modified online continuous method was further compared with the recently developed cavity ring down measurement principle. The precision is significantly better for the commercially available laser-based system than our current version of improved online CoF3 conversion method using mass spectrometry. Factors identified for limiting precision in our continuous flow system are: (i) compaction of the reactor with time that leads to the restriction of flow rate of carrier gas, (ii) the CoF3 treatment, (iii) the amount of CoF3 inside the reactor, (iv) the pore size of the steel frit, and (v) the metallic tube. Changes in all of these items as well as the dimension of the fused silica capillary, the positioning of the fused silica capillary in the open split, and the memory effect can also lead to a declining precision. These limiting factors for precision still provide us enough space for further improvement of our improved online method which will be worthwhile for the measurement of smaller aliquot samples as fluid inclusions for palaeoclimatic applications. With present improvement, multiple injections (n = 15 or even more) should be applied to obtain a precision better than 10 per meg for Δ17O. Furthermore, a comparison of the laser-based system with an improved conventional equilibration method has been made on precipitation samples originating from Jungfraujoch.
Estimating Market Potential for Solar Photovoltaic Systems in Uganda
Authors: Aarakit Sylvia Manjeri , Ssennono Vincent Fred , Adaramola Muyiwa S.
Published: March 2021

With only 28% of the population having access to electricity, Uganda presents a huge market potential for alternative technologies to provide electricity such as solar PV systems. Using a simple statistical method (neighbourhood approach), this study estimates the market potential for solar PV in households based on a 2018 National Electrification Survey dataset collected by Uganda Bureau of Statistics (UBOS). Results show that approximately 5.3 million households lack access to electricity, thus the total market potential. Over 60% of households lack access to electricity due to supply-side gaps (also known as absence of coverage) while the rest of the households have coverage but lack access due to demand side limitations (also known as no uptake). On the contrary, our results suggest that supply-side gaps constitute the biggest proportion of electricity access deficit in Uganda’s households. Implying that these households may be willing and have the ability to pay but lack supply, thus these households constitute an immediate market potential for solar PV systems. To address the electricity access deficit, private solar companies should target unserved households with appropriate systems/products and innovative business models to suit their needs. Government on the other hand should subsidize households with affordability challenges or enhance their income.
Novel Virus-Like Particle Vaccine Encoding the Circumsporozoite Protein of Plasmodium falciparum Is Immunogenic and Induces Functional Antibody Responses in Mice
Authors: Kurtovic Liriye , Wetzel David , Reiling Linda , Drew Damien R. , Palmer Catherine , Kouskousis Betty , Hanssen Eric , Wines Bruce D. , Hogarth P. Mark , Suckow Manfred , Jenzelewski Volker , Piontek Michael , Chan Jo-Anne , Beeson James G.
Published: March 2021

RTS,S is the leading malaria vaccine in development, but has demonstrated only moderate protective efficacy in clinical trials. RTS,S is a virus-like particle (VLP) that uses the human hepatitis B virus as scaffold to display the malaria sporozoite antigen, circumsporozoite protein (CSP). Particle formation requires four-fold excess scaffold antigen, and as a result, CSP represents only a small portion of the final vaccine construct. Alternative VLP or nanoparticle platforms that reduce the amount of scaffold antigen and increase the amount of the target CSP antigen present in particles may enhance vaccine immunogenicity and efficacy. Here, we describe the production and characterization of a novel VLP that uses the small surface antigen (dS) of duck hepatitis B virus to display CSP. The CSP-dS fusion protein successfully formed VLPs without the need for excess scaffold antigen, and thus CSP represented a larger portion of the vaccine construct. CSP-dS formed large particles approximately 31-74 nm in size and were confirmed to display CSP on the surface. CSP-dS VLPs were highly immunogenic in mice and induced antibodies to multiple regions of CSP, even when administered at a lower vaccine dosage. Vaccine-induced antibodies demonstrated relevant functional activities, including Fc-dependent interactions with complement and Fcγ-receptors, previously identified as important in malaria immunity. Further, vaccine-induced antibodies had similar properties (epitope-specificity and avidity) to monoclonal antibodies that are protective in mouse models. Our novel platform to produce VLPs without excess scaffold protein has wide implications for the future development of vaccines for malaria and other infectious diseases.
Delayed Gut Colonization Shapes Future Allergic Responses in a Murine Model of Atopic Dermatitis
Authors: Arildsen Amalie W. , Zachariassen Line F. , Krych Lukasz , Hansen Axel K. , Hansen Camilla H. F.
Published: March 2021

Epidemiological studies have long reported that perturbations of the childhood microbiome increase the risk of developing allergies, but a causal relationship with atopic dermatitis remains unclear. Here we colonized germ-free mice at birth or at one or eight week-of-age to investigate the role of prenatal and early postnatal microbial exposure on development of oxozolone-induced dermatitis later in life. We demonstrate that only one week delayed microbial colonization increased IgE levels and the total histological score of the inflamed ear compared to mice colonized throughout life. In parallel, several pro-inflammatory cytokines and chemokines were upregulated in the ear tissue demonstrating an enhanced immunological response following delayed postnatal colonization of the gut. In contrast, sensitivity to oxazolone-induced dermatitis was unaffected by the presence of a maternal microbiota during gestation. Mice colonized at eight week-of-age failed to colonize Rikenellaceae, a group of bacteria previously associated with a high-responding phenotype, and did not develop an immunological response to the same extent as the early colonized mice despite pronounced histopathological manifestations. The study provides proof-of-principle that the first intestinal colonizers of mice pups are crucial for the development of oxazolone-induced dermatitis later in life, and that the status of the maternal microbiota during pregnancy has no influence on the offspring’s allergic immune response. This highlights an important window of opportunity following birth for microbiota-mediated interventions to prevent atopic responses later in life. How long such a window is open may vary between mice and humans considering species differences in the ontogeny of the immune system.
The PREdictor of MAlnutrition in Systemic Sclerosis (PREMASS) Score: A Combined Index to Predict 12 Months Onset of Malnutrition in Systemic Sclerosis
Authors: Bagnato Gianluca , Pigatto Erika , Bitto Alessandra , Pizzino Gabriele , Irrera Natasha , Abignano Giuseppina , Ferrera Antonino , Sciortino Davide , Wilson Michelle , Squadrito Francesco , Buch Maya H. , Emery Paul , Zanatta Elisabetta , Gangemi Sebastiano , Saitta Antonino , Cozzi Franco , Roberts William Neal , Del Galdo Francesco
Published: March 2021

Objective: Malnutrition is a severe complication in Systemic Sclerosis (SSc) and it is associated with significant mortality. Notwithstanding, there is no defined screening or clinical pathway for patients, which is hampering effective management and limiting the opportunity for early intervention. Here we aim to identify a combined index predictive of malnutrition at 12 months using clinical data and specific serum adipokines.

Methods: This was an international, multicentre observational study involving 159 SSc patients in two independent discovery (n = 98) and validation (n = 61) cohorts. Besides routine clinical and serum data at baseline and 12 months, Malnutrition Universal Screening Tool (MUST) score and serum concentration of leptin and adiponectin were measured for each participant at baseline. The endpoint of malnutrition was defined according to European Society of Clinical Nutrition and Metabolism (ESPEN) recommendation. Significant parameters from univariate analysis were tested in logistic regression analysis to identify the predictive index of malnutrition in the derivation cohort.

Results: The onset of malnutrition at 12 months correlated with adiponectin, leptin and their ratio (A/L), MUST, clinical subset, disease duration, Scl70 and Forced Vital Capaciy (FVC). Logistic regression analysis defined the formula: −2.13 + (A/L*0.45) + (Scl70*0.28) as the best PREdictor of MAlnutrition in SSc (PREMASS) (AUC = 0.96; 95% CI 0.93, 0.99). PREMASS < −1.46 had a positive predictive value (PPV) > 62% and negative predictive value (NPV) > 97% for malnutrition at 12 months.

Conclusion: PREMASS is a feasible index which has shown very good performance in two independent cohorts for predicting malnutrition at 12 months in SSc. The implementation of PREMASS could aid both in clinical management and clinical trial stratification/enrichment to target malnutrition in SSc.
Novel Peptides Targeting the β-Clamp Rapidly Kill Planktonic and Biofilm Staphylococcus epidermidis Both in vitro and in vivo
Authors: Raeder Synnøve Brandt , Sandbakken Erik Thorvaldsen , Nepal Anala , Løseth Kirsti , Bergh Kåre , Witsø Eivind , Otterlei Marit
Published: March 2021

Antimicrobial resistance is an increasing threat to global health and challenges the way we treat infections. Peptides containing the PCNA interacting motif APIM (APIM-peptides) were recently shown to bind to the bacterial PCNA homolog, the beta (β)-clamp, and to have both antibacterial and anti-mutagenic activities. In this study we explore the antibacterial effects of these peptides on Staphylococcus epidermidis, a bacterial species commonly found in prosthetic joint infections (PJI). Drug-resistant bacterial isolates from PJIs often lead to difficult-to-treat chronic infections. We show that APIM-peptides have a rapid bactericidal effect which when used at sublethal levels also increase the efficacy of gentamicin. In addition, APIM-peptides reduce development and eliminate already existing S. epidermidis biofilm. To study the potential use of APIM-peptides to prevent PJI, we used an in vivo bone graft model in rats where APIM-peptide, gentamicin, or a combination of the two was added to cement. The bone grafts containing cement with the combination was more effective than cement containing only gentamicin, which is the current standard of care. In summary, these results suggest that APIM-peptides can be a promising new drug candidate for anti-infective implant materials to use in the fight against resistant bacteria and chronic PJI.
Combinatorial Antimicrobial Efficacy and Mechanism of Linalool Against Clinically Relevant Klebsiella pneumoniae
Authors: Yang Shun-Kai , Yusoff Khatijah , Ajat Mokrish , Wee Chien-Yeong , Yap Polly-Soo-Xi , Lim Swee-Hua-Erin , Lai Kok-Song
Published: March 2021

Antibiotic–adjuvant combinatory therapy serves as a viable treatment option in addressing antibiotic resistance in the clinical setting. This study was carried out to assess and characterize the adjuvant potential and mode of action of linalool against carbapenemase-producing Klebsiella pneumoniae (KPC-KP). Linalool exhibited bactericidal activity alone (11,250 μg/ml) and in combination with meropenem (5,625 μg/ml). Comparative proteomic analysis showed significant reduction in the number of cytoplasmic and membrane proteins, indicating membrane damage in linalool-treated KPC-KP cells. Upregulation of oxidative stress regulator proteins and downregulation of oxidative stress-sensitive proteins indicated oxidative stress. Zeta potential measurement and outer membrane permeability assay revealed that linalool increases the bacterial surface charge as well as the membrane permeability. Intracellular leakage of nucleic acid and proteins was detected upon linalool treatment. Scanning and transmission electron microscopies further revealed the breakage of bacterial membrane and loss of intracellular materials. Linalool induced oxidative stress by generating reactive oxygen species (ROS) which initiates lipid peroxidation, leading to damage of the bacterial membrane. This leads to intracellular leakage, eventually killing the KPC-KP cells. Our study demonstrated that linalool possesses great potential in future clinical applications as an adjuvant along with existing antibiotics attributed to their ability in disrupting the bacterial membrane by inducing oxidative stress. This facilitates the uptake of antibiotics into the bacterial cells, enhancing bacterial killing.
Improving Emotion Regulation Through Real-Time Neurofeedback Training on the Right Dorsolateral Prefrontal Cortex: Evidence From Behavioral and Brain Network Analyses
Authors: Yu Linlin , Long Quanshan , Tang Yancheng , Yin Shouhang , Chen Zijun , Zhu Chaozhe , Chen Antao
Published: March 2021

We investigated if emotion regulation can be improved through self-regulation training on non-emotional brain regions, as well as how to change the brain networks implicated in this process. During the training period, the participants were instructed to up-regulate their right dorsolateral prefrontal cortex (rDLPFC) activity according to real-time functional near-infrared spectroscopy (fNIRS) neurofeedback signals, and there was no emotional element. The results showed that the training significantly increased emotion regulation, resting-state functional connectivity (rsFC) within the emotion regulation network (ERN) and frontoparietal network (FPN), and rsFC between the ERN and amygdala; however, training did not influence the rsFC between the FPN and the amygdala. However, self-regulation training on rDLPFC significantly improved emotion regulation and generally increased the rsFCs within the networks; the rsFC between the ERN and amygdala was also selectively increased. The present study also described a safe approach that may improve emotion regulation through self-regulation training on non-emotional brain regions.
Spectral Resting-State EEG (rsEEG) in Chronic Aphasia Is Reliable, Sensitive, and Correlates With Functional Behavior
Authors: Dalton Sarah G. H. , Cavanagh James F. , Richardson Jessica D.
Published: March 2021

We investigated spectral resting-state EEG in persons with chronic stroke-induced aphasia to determine its reliability, sensitivity, and relationship to functional behaviors. Resting-state EEG has not yet been characterized in this population and was selected given the demonstrated potential of resting-state investigations using other neuroimaging techniques to guide clinical decision-making. Controls and persons with chronic stroke-induced aphasia completed two EEG recording sessions, separated by approximately 1 month, as well as behavioral assessments of language, sensorimotor, and cognitive domains. Power in the classic frequency bands (delta, theta, alpha, and beta) was examined via spectral analysis of resting-state EEG data. Results suggest that power in the theta, alpha, and beta bands is reliable for use as a repeated measure. Significantly greater theta and lower beta power was observed in persons with aphasia (PWAs) than controls. Finally, in PWAs theta power negatively correlated with performance on a discourse informativeness measure, while alpha and beta power positively correlated with performance on the same measure. This indicates that spectral rsEEG slowing observed in PWAs in the chronic stage is pathological and suggests a possible avenue for directly altering brain activation to improve behavioral function. Taken together, these results suggest that spectral resting-state EEG holds promise for sensitive measurement of functioning and change in persons with chronic aphasia. Future studies investigating the utility of these measures as biomarkers of frank or latent aphasic deficits and treatment response in chronic stroke-induced aphasia are warranted.
Food Entrainment, Arousal, and Motivation in the Neonatal Rabbit Pup
Authors: Caba Mario , Lehman Michael N. , Caba-Flores Mario Daniel
Published: March 2021

In the newborn rabbit, the light entrainable circadian system is immature and once a day nursing provides the primary timing cue for entrainment. In advance of the mother’s arrival, pups display food anticipatory activity (FAA), and metabolic and physiological parameters are synchronized to this daily event. Central structures in the brain are also entrained as indicated by expression of Fos and Per1 proteins, GFAP, a glial marker, and cytochrome oxidase activity. Under fasting conditions, several of these rhythmic parameters persist in the periphery and brain, including rhythms in the olfactory bulb (OB). Here we provide an overview of these physiological and neurobiological changes and focus on three issues, just beginning to be examined in the rabbit. First, we review evidence supporting roles for the organum vasculosum of lamina terminalis (OVLT) and median preoptic nucleus (MnPO) in homeostasis of fluid ingestion and the neural basis of arousal, the latter which also includes the role of the orexigenic system. Second, since FAA in association with the daily visit of the mother is an example of conditioned learning, we review evidence for changes in the corticolimbic system and identified nuclei in the amygdala and extended amygdala as part of the neural substrate responsible for FAA. Third, we review recent evidence supporting the role of oxytocinergic cells of the paraventricular hypothalamic nucleus (PVN) as a link to the autonomic system that underlies physiological events, which occur in preparation for the upcoming next daily meal. We conclude that the rabbit model has contributed to an overall understanding of food entrainment.