bluuebunny/crossref_metadata_2025 huggingface dataset:
Macrophage mediated recognition and clearance of Borrelia burgdorferi elicits MyD88-dependent and -independent phagosomal signals that contribute to phagocytosis and inflammation
Authors: Benjamin Sarah , Hawley Kelly L. , Vera-Licona Paola , Vake Carson J. La , Cervantes Jorge L. , Ruan Yijun , Radolf Justin D. , Salazar Juan C.
Published: March 2021

Background: Macrophages play prominent roles in bacteria recognition and clearance, including Borrelia burgdorferi (Bb), the Lyme disease spirochete. To elucidate mechanisms by which MyD88/TLR signaling enhances clearance of Bb by macrophages, we studied wildtype (WT) and MyD88-/- Bb-stimulated bone marrow-derived macrophages (BMDMs). Results: MyD88-/- BMDMs exhibit impaired uptake of spirochetes but comparable maturation of phagosomes following internalization of spirochetes. RNA-sequencing of infected WT and MyD88-/- BMDMs identified a large cohort of differentially expressed MyD88-dependent genes associated with re-organization of actin and cytoskeleton during phagocytosis along with several MyD88-independent chemokines involved in inflammatory cell recruitment. We computationally generated networks which identified several MyD88-dependent intermediate proteins (Rhoq and Cyfip1) that are known to mediate inflammation and phagocytosis respectively. Conclusion: Our findings show that MyD88 signaling enhances, but is not required, for bacterial uptake or phagosomal maturation and provide mechanistic insights into how MyD88-mediated phagosomal signaling enhances Bb uptake and clearance.
Description of the use of Multicriteria to Support Pricing and Reimbursement Decisions by European Health Technology Assessment Bodies.
Authors: Elvira David , Obach Mercè , Pontes Caridad
Published: March 2021

BackgroundHeterogeneity in drug access throughout Europe may be influenced by differences in drug-assessment strategies. The EUnetHTA’s assessment core model (EUnetHTA-core) and the EVIDEM’s multicriteria framework are reference methodologies in this context, the latter including a wider compromise between non-contextual and contextual criteria. Compliance of 37 European Health Technology Assessment bodies (HTAb) with EUnetHTA-core has been reported, but the use of EVIDEM by this HTAb is still unknown.ObjectiveTo describe the uptake and use of multicriteria approaches to evaluate drug value by European HTAb using EVIDEM as reference framework. MethodsMulticriteria framework was obtained based on EVIDEM model. The criteria used for drug appraisal by HTAb was extracted from the EUnetHTA report, and completed through search of websites, publications and HTAb reports. Use of EVIDEM assessment model in 37 European HTAb has been described semi-quantitatively and summarized using an alignment heatmap.ResultsAligned, medium or misaligned profiles were seen for 24,3%, 51,4% and 24,3% of HTAb when matching to EVIDEM dimensions and criteria was considered. HTAb with explicit responsibilities in providing specific advice on reimbursement showed more aligned profiles on contextual and non-contextual dimensions. ConclusionsMost of the 37 European HTAb have room to broaden their contextual assessment tools, especially when social and medical perception of need requires to be explicit to support payer’s decision on reimbursement.
Multidisciplinary residential home intervention to improve outcomes for frail residents
Authors: Steel Anna , Hopwood Helen , Goodwin Elizabeth , Sampson Elizabeth L
Published: March 2021

BackgroundResidential homes provide accommodation and assistance with personal care only and are not required to have registered nurses on site. However, their residents often have a combination of comorbidity, polypharmacy, frailty and mental-health conditions with poor access to healthcare to meet these needs. Integrated healthcare for older people is a key NHS priority in the Long-Term Plan and the Five-Year Forward View. We describe development and implementation of multi-disciplinary intervention to integrate healthcare and promote interprofessional education.MethodsA multi-disciplinary residential home quality improvement project in two cycles by a team comprising senior and trainee general practitioners, trainees in geriatrics, psychiatry, pharmacist and residential home senior staff. The intervention was underpinned by the framework for enhanced health in care homes including Comprehensive Geriatric Assessment (CGA) and mental-health review. Each intervention session included an educational presentation by a team member consideration of each resident in a pre-evaluation multi-disciplinary discussion followed by a structured clinical assessment and discussion of proposed management.ResultsThree residential homes participated with a total 34 residents receiving intervention. In one residential home, there was a 75% reduction in admissions for those reviewed and a reduction in overall admission costs. Polypharmacy was reduced by an average of 2 medications per resident across the three sites. There was a 63% increase in cardio-pulmonary resuscitation decisions and 76% increase in advance care planning discussions.ConclusionThis was an effective model for multi-disciplinary trainees working with a perceived impact on physical and mental health, and valuable opportunities for sharing learning.
Optimal Booking Control for Physical Examination considering Late Cancellation and Overbooking
Authors: Ho Te-Wei , Kung Ling-Chieh , Lai Jui-Fen , Chiu Han-Mo
Published: March 2021

Background: Late cancellation of physical examination has a severe impact on the profit of a healthcare center since it is often too late to ll the vacancy. A booking control policy that considers overbooking is then one natural solution.Case presentation: In this study, we consider a healthcare center providing different examination sets using dierent resources. As each resource has its unique cost, revenue, and capacity, the optimal booking limits of all examination sets are hard to be calculated. We propose a probabilistic optimization model that maximizes the expected prot given the late cancellation probability of each type of customer, where the probabilities are estimated through logistic regression and customer grouping using historical booking and cancellation records. To test the performance of our proposed solution, we collaborate with a leading healthcare center. We simulate the presence and absence of customers generated by historical records and compare different strategies of overbooking.Conclusions: Through the experiment, we show that our method can significantly increase the expected profit of the healthcare center by around 11%.
HPV Positivity and Risk of Cervical Cancer according to HIV-Infection: A Comparative Assessment in the Population of Cameroonian Women
Authors: SOSSO Samuel Martin , TCHOUAKET Michel Carlos TOMMO , Fokam Joseph , Simo Rachel Kamgaing , Semengue Ezechiel Ngoufack Jagni , Sando Zacharie , Torimiro Judith , Tiga Aline , Lobe Elise Elong , Ambada Georgia , Nange Achille , Nka Alex Durand , Tala Valère , Chenwi Collins , ABBA Aissatou , Ka’e Aude Christelle , Fainguem Nadine , Zam Marie Krystel Nnomo , Yagai Bouba , Billong Serge Clotaire , Colizzi Vittorio , Ndjolo Alexis
Published: March 2021

Background

Cervical cancer, caused by the human papillomavirus (HPV), remains a global health challenge. In HIV highly-burdened settings, it would be relevant to understand the severity of cervical cancer in case of co-infection with HPV. We therefore sought to determine the effect of HPV on the occurrence of cervical lesions among women with versus without HIV-infection.
Methods

A cross-sectional analytical study was conducted throughout 2012 among 257 women living in Yaoundé, Cameroon. HIV serology, genotyping of high-risk oncogenic HPV and cervical vaginal smear (CVS) were performed for all participants; among those reported to be HIV seropositive, HIV plasma viral load and CD4 count were measured. Results of the CVS were interpreted following the Bethesda 2001 guidelines. Statistical analyses were performed using Graph Pad version 6.0; p < 0.05 was considered statistically significant.
Results

The mean age of our study participants was 37 ± 6.5 years. According to HIV serology, 184 (71.59%) were HIV-positive vs. 73 (28.40%) HIV-negative women, with a similar age distribution respectively (36 ± 2.80 years versus 42 ± 8.48 years). Among HIV-positive women, median CD4 was 438 [IQR: 317–597] cells/mm3 and median viremia < 40 [IQR: <40 − 2318] copies/mL. Following successful genotyping, the prevalence of high-risk oncogenic HPV was 36.32% (73/201), with a significantly higher proportion among those with HIV-infection (41.98% [55/131] vs. 25.71% [18/70]; p = 0.02; OR = 2.1). CVS revealed 31.74% (97) normal cervix; 38.91% (100) inflammation; 16.34% (42) low-grade squamous intra-epithelial lesion; 6.34% (18) high-grade squamous intra-epithelial lesion. Overall rate of cervical lesions was 23.34% (60/257), with a non-significantly higher proportion in HIV-infected participants (25.00% [46/184] versus 19.17% [14/73]; p = 0.31). Of relevance, the presence of high-risk oncogenic HPV was significantly associated with cervical lesions (p < 0.0001; OR = 5.07), with a higher risk of cervical lesion among HIV-positive (p < 0.0001 and OR = 5.67) versus HIV-negative (p = 0.03 and OR = 3.83).
Conclusion

Though oncogenic HPV appears as an independent factor of the occurrence of cervical lesions, the risk of cervical lesion is substantially higher among HIV/HPV co-infection compared to HPV-infection alone. Thus, prevention of cervical cancer should be prioritised for women living with HIV-infection in HPV-endemic settings.
METHODS OF QUALITY CONTROL OF PHONOGRAMS DURING RESTORATION AND RECOVERY
Authors: Grebin Alex , Levenets Ninel , Shvaichenko Volodymyr
Published: March 2021

The object of research. Process of phonograms restoration and recovery are described.
Investigated problem. Differences between some methods of quality control of phonograms during and after their restoration and recovery were investigated.
The main scientific results. An instrumental method for objective assessment of the quality of phonograms is proposed, based on a non-intrusive model with parametric modeling of the phonogram signal to assess the effect of an artifact on a phonogram.
The area of practical use of the research results. The results of the operational control of objective quality indicators of a real sound signal using virtual measuring instruments built into the software for working with sound are considered.
An innovative technological product: a technology for assessing the quality of phonograms in the process of restoration and recovery (R&R), which makes it possible to objectively assess the quality of phonograms, taking into account artifacts of phonograms caused by the method of recording phonograms, the conditions of their storage, etc. enough high quality restored audio content.
Scope of application of the innovative technological product: studio of restoration and recovery of sound phonograms on analog media, recording studios, technological processes of conversion and processing of sound programs, archives of radio and television recordings.
UTERINE FIBROIDS IN EARLY REPRODUCTIVE AGE WOMEN: FEATURES OF MORPHOLOGY, HORMONAL STATUS AND REHABILITATION
Authors: Vdovichenko Serhii , Bober Anna , Lubkovska Oleksandra , Strakhovetskyi Vitalii
Published: March 2021

The object of the study: Uterine fibroids (UF) in women of early reproductive age.
The problem to be solved: Improving the effectiveness of postoperative rehabilitation in women of early reproductive age with uterine fibroids based on the study of its morphological features and improvement of rehabilitation measures.
The main scientific results: It was found that in women of early reproductive age with UF the most common complaints are posthemorrhagic anemia (61.0 %, or 61 women). Regarding the menstrual cycle, the most common dysmenorrhea – 26.0 % (in 26 women). The importance of heredity in the development of such pathology in young women (32.0 %, or 32 women) was confirmed. The most common localization of fibroids is interstitial – 79.0 % (in 79 women).
Morphological study found that women of early reproductive age most often have a simple UF, namely 96 % (96 women). Uterine leiomyoma was present in 56 % (56 women).
A study of the hormonal status of women of early reproductive age found that the mean values ​​of hormones such as follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol, progesterone, prolactin and testosterone were higher before surgery than after. When comparing rehabilitation methods (combined oral contraceptives (COCs) or gonadotropin-releasing hormone agonists (GnRH agonists), it was found that postoperative rehabilitation by using COCs for 6-12 months provides significantly better indicators of recovery of hormonal status, indicating the effectiveness of rehabilitation method.
Scope of practical application of research results: Practical medicine specializing in the diagnosis, treatment and prevention of recurrence of uterine fibroids.
Innovative technological product: Improved algorithm of postoperative rehabilitation measures by applying COC for 6-12 months after myomectomy, which provides significantly better results in restoring hormonal status during rehabilitation.
Scope of application of innovative technological product: clinical medical practice related to the diagnosis, treatment and prevention of recurrence of uterine fibroids.
EDİNİLMİŞ MALLARA KATILMA REJİMİNDE DEĞER ARTIŞINA KATILMA
Authors: BELGE Ayşe Merve
Published: March 2021

Edinilmiş mallara katılma rejiminde değer artışına katılmaya ilişkin iki farklı kanuni düzenleme bulunmaktadır. Bunlardan biri Türk Medeni Kanunu’nun 227. maddesinde yer alan değer artış payı alacağına ilişkin düzenleme; diğeri ise Türk Medeni Kanunu’nun 230. maddesinin üçüncü fıkrasında yer alan denkleştirme alacağına ilişkin düzenlemedir. Her iki düzenleme de bir malın edinilmesine, iyileştirilmesine ya da korunmasına yönelik olarak yapılan katkı sonucunda, katkıda bulunulan malda bir değer artışının meydana gelmesi durumunda, bir alacak hakkına sahip olunacağını hüküm altına alarak değer artışına katılmayı öngörmektedir. Bu iki hüküm arasında bu gibi birtakım benzerlikler bulunduğu gibi farklılıklar da bulunmaktadır. Çalışma, anılan hükümlerde düzenlenen, değer artış payı alacağı ve denkleştirme alacağına ilişkin açıklamalarda bulunmak suretiyle bu iki hükmün karşılaştırılmasına yöneliktir. Bu kapsamda öncelikle, değer artış payı alacağı, daha sonra denkleştirme alacağına ilişkin açıklamalara, yalnız karşılaştırma faaliyetine hizmet edeceği ölçüde yer verilmiştir. Son olarak ise bu iki alacak üzerinden, hükümler arasındaki benzerlik ve farklılıklar ele alınmıştır. Bu benzerlik ve farklılıklar, kanunda ele alınış tarzları, hukuki nitelik, alacağın özgüleneceği mal grubu ve hesaplama yöntemi noktalarında toplanmıştır.
Corpo/Palavra/Sangue: O Levante de Sangria
Authors: Schmidt Rita Terezinha
Published: March 2021

Published in 2017, the poetic work entitled Sangria, by the Brazilian poet Luiza Romão, surprises by its sui generis format aligned with an original and daring theme that stages in the word-body-image the phases of the female menstrual cycle orchestrated with the cycles of Brazilian history, from colonization to the parliamentary coup that led to the impeachment of then President Dilma Roussef in 2016. In the considerations on the set of 28 poems I highlight some issues of form, language and thematic treatment, with emphasis on gender and race issues regarding the female body and its domestication in the country’s continuous history of patriarchal violence. I argue that in the projection of the history of Brazilianness as sterile because it is based on the rape of the virgin land / female body, the plundering of its wealth and the coup against democracy, Sangria explores silenced borders in official history, using the power of words and images in a performance act that evokes its affiliation to the tradition of slam poetry. In this sense, the work inscribes an artistic / political activism on the part of the lyrical self that, through denunciation and insurrection, projects the desire for social transformation.
“For your Faithful Lord, Life is Changed not Ended”. The Roman Catholic Funeral Rite in Flanders and the Paschal Mystery
Authors: Goyvaerts Samuel
Published: March 2021

Since Vatican II, the paschal mystery has become the focal point of all liturgy, a development that also has consequences for the Roman Catholic funeral liturgy. Celebrating the funeral in the context of the Eucharist underscores the concept of the paschal mystery very explicitly. Since 2011, a number of factors has led to the funeral liturgy without Eucharist becoming the liturgical norm in Flanders. This paper investigates this shift in light of the funeral liturgy being a memorial of the paschal mystery. It (1) sketches the shift that occurred in the revised funeral rite, (2) presents a detailed study of the new Flemish approach towards the funeral liturgy, using the diocese of Hasselt as an example, and (3) evaluates this new approach to the funeral liturgy, specifically from the perspective of the liturgy as a memorial of the paschal mystery. Finally, some conclusions regarding this case from a liturgical-theological and pastoral point of view are formulated.
Social Media and Emotional Burnout Regulation During the COVID-19 Pandemic: Multilevel Approach
Authors: Shao Ruosi , Shi Zhen , Zhang Di
Published: March 2021

Background

In February 2020, the Chinese government imposed a complete lockdown of Wuhan and other cities in Hubei Province to contain a spike of COVID-19 cases. Although such measures are effective in preventing the spread of the virus, medical professionals strongly voiced a caveat concerning the pandemic emotional burnout at the individual level. Although the lockdown limited individuals’ interpersonal communication with people in their social networks, it is common that individuals turn to social media to seek and share health information, exchange social support, and express pandemic-generated feelings.

Objective

Based on a holistic and multilevel perspective, this study examines how pandemic-related emotional exhaustion enacts intrapersonal, interpersonal, and hyperpersonal emotional regulation strategies, and then evaluates the effectiveness of these strategies, with a particular interest in understanding the role of hyperpersonal-level regulation or social media–based regulation.

Methods

Using an online panel, this study sampled 538 Chinese internet users from Hubei Province, the epicenter of the COVID-19 outbreak in China. Survey data collection lasted for 12 days from February 7-18, 2020, two weeks after Hubei Province was placed under quarantine. The sample had an average age of 35 (SD 10.65, range 18-78) years, and a majority were married (n=369, 68.6%).

Results

Using structural equation modeling, this study found that intrapersonal-level (B=0.22; β=.24; P<.001) and interpersonal-level (B=0.35; β=.49; P<.001) emotional regulation strategies were positively associated with individuals’ outcome reappraisal. In contrast with intrapersonal and interpersonal regulations, hyperpersonal (social media–based) regulation strategies, such as disclosing and retweeting negative emotions, were negatively related to the outcome reappraisal (B=–1.00; β=–.80; P<.001).

Conclusions

Consistent with previous literature, intrapersonal-level regulation (eg, cognitive reappraisal, mindfulness, and self-kindness) and interpersonal-level supportive interaction may generate a buffering effect on emotional exhaustion and promote individuals’ reappraisal toward the stressful situation. However, hyperpersonal-level regulation may exacerbate the experienced negative emotions and impede reappraisal of the pandemic situation. It is speculated that retweeting content that contains pandemic-related stress and anxiety may cause a digital emotion contagion. Individuals who share other people’s negative emotional expressions on social media are likely to be affected by the negative affect contagion. More importantly, the possible benefits of intrapersonal and interpersonal emotion regulations may be counteracted by social media or hyperpersonal regulation. This suggests the necessity to conduct social media–based health communication interventions to mitigate the social media–wide negative affect contagion if lockdown policies related to highly infectious diseases are initiated.
Inequidad en el impuesto inmobiliario: análisis multicriterio (CRITIC) del valor catastral de vivienda en Mazatlán
Authors: Colado Velázquez Luis Alfonso , Roca Cladera Josep , Humarán Nahed Iván
Published: March 2021

En el presente documento se reportan los resultados obtenidos en el análisis multicriterio CRITIC y espacial realizado a 1062 viviendas en Mazatlán, Sinaloa (México); asimismo, se especifican las variables que conforman el Valor Catastral para cada una de las categorías catastrales de vivienda que van de M2 hasta M7, establecidas en el Instructivo de Valuación del estado de Sinaloa; donde se obtuvieron las ponderaciones de cada criterio y la información con la que se analiza la situación actual de influencia de cada variable y cómo, a partir de estos datos, se puede demostrar la inequidad al obtener el valor catastral de vivienda.
Componentes de la asociatividad empresarial y gobernanza en Áreas Naturales Protegidas con capacidades turísticas
Authors: Lucero Lopez Dulce Maria , Torres Garcia Alberto Francisco
Published: March 2021

El presente artículo tiene como propósito analizar los conceptos de asociatividad empresarial y gobernanza, con énfasis en Áreas Naturales Protegidas (ANP) dedicadas a la prestación de servicios turísticos. Para ello, se define el concepto de asociatividad empresarial y sus posibles contribuciones al desarrollo económico. Igualmente, se examina la noción de gobernanza como elemento en la implementación de modelos asociativos. La metodología empleada es de tipo exploratoria. Los resultados obtenidos son la determinación de los componentes que integran los procesos de asociatividad, así como un marco conceptual queexplica la importancia de la gobernanza en el cumplimiento de los objetivos comunitarios
Determinantes dos preços de ingressos de futebol do campeonato brasileiro, 2012 a 2018
Authors: Profeta Graciela , Nunes Thomaz Ivens , De Melo Abrita Bastos Patrícia , Faria dos Santos Vladimir
Published: March 2021

Neste artigo objetivou mensurar as relações entre os determinantes dos preços dos ingressos de futebol para o Campeonato Brasileiro, de 2012 a 2018. Utilizouse a literatura para identificar determinantes e adotou-se a teoria do custo total formulada por Hall e Hitch. Para a estimação das relações entre os determinantes e os preços dos ingressos de futebol aplicou-se modelos de dados em painel. Os resultados apontaram que a maioria dos determinantes explicavam os preços. Logo, a teoria do custo total de Hall e Hitch e o modelo empírico explicaram a formação de preços para os ingressos de futebol no Brasil.
Seed and Germination Study of a New Guinea Endemic Plant Species Grevillea papuana Diels.
Authors: Kuswantoro Farid
Published: March 2021

Grevillea papuana is a culturally important endemic plant species of New Guinea highland. Although G. papuana conservation and propagation attempts were already conducted, this species seed and germination characters information were still very limited. This study aimed to provide information regarding G. papuana seed and germination biology. Seed characteristic and germination trials were conducted in this study. Data analysis was conducted descriptively, while germination parameters were also calculated. G. papuana has a light, elliptic, and winged seed. The species germination was low and ununiform with phanerocotylar epigeal foliaceous (PEF) seedling functional type.
EFFECTS OF WORK ENVIRONMENT ON STAFF TRAINING TRANSFER IN GHANAIAN TECHNOLOGY UNIVERSITIES AND POLYTECHNICS
Authors: APPIAH ROBERT , AHETO SIMON-PETER KAFUI
Published: March 2021

This study sought to determine the effect of post-training work environment on the transfer of middle-level staff competencies from 2 technical universities and 2 polytechnics in the northern sector of Ghana. The mixed study was sequential explanatory research. Respondents were drawn from the Netherlands Programme for Post-Secondary Education and Training Capacity (NPT/GHA) 45 leadership and management capacity building project for the middle-level technical universities and polytechnics staff. A 5-point Likert scale questionnaire and a semi-structured interview guide were used to gather data from respondents made up of 24 (58.5%) academic staff and 17 (41.5%) administrative staff totaling 41 respondents for the study. The closed-ended items were analysed using statistical product and service solutions version 19 and results reported using means and standard deviations. Open-ended items were thematically analysed to support results from the closed-ended item analysis. The results revealed that respondents found the relevance of staff training, learned new things and noticed an improvement in their competencies for their career prospects. However, the perception of the respondents pointed to the fact that there was little or no support from colleagues in transferring the competencies acquired from training. The study also revealed that respondents had low motivation to transfer training competencies. Since technical universities and polytechnics produce critical human resources for the industry, the post-training work environment was critical for staff training transfer with many implications for the management, leadership, growth and development of the institutions. The study recommended that training programmes should be aligned with the institutional vision, mission and goals. Again, resources committed to staff training should also budget for enhancements of the work environment to accommodate training transfer using modern technologies.
A STUDY ON DRUG UTILIZATION EVALUATION AND POTENTIAL DRUG RELATED PROBLEMS IN TYPE-2 DIABETES MELLITUS PATIENTS WITH CO-MORBIDITIES IN A TERTIARY CARE HOSPITAL
Authors: RODRIGUES PRUDENCE A. , DAMIEN DAWN TESLIN , K. T. MARY CECIL , M. NARESH KUMAR , S. S. RESHMA , KUMAR R. SENTHIL
Published: March 2021

Objective: The objective of this study is to evaluate prescribing pattern, analyze drug-related problems, identify co-morbidities and complications in Type 2 Diabetes Mellitus patients and also to perform cost analysis of Biguanides, Sulfonylureas, Dipeptidyl Peptidase Inhibitors

Methods: A Prospective observational study was done in General Medicine and Endocrinology Departments of PSG Hospitals. A total of 200 study subjects, including both inpatients and outpatients, above 18 y of age, prescribed with OHAs (Biguanides, Sulfonylureas and DPP4 inhibitors) were included in the study.

Results: Diabetes was more prevalent among males. OHAs were most prescribed in the age group of 51-60 y. Hypertension (71%) was the most common comorbidity and Diabetic neuropathy (23%) was the most common complication found in the patients. Multidrug therapy (72.5%) was most prescribed in diabetic patients, followed by Biguanides. Hypoglycemia was the most prevalent ADR. Cost analysis showed that T. Linagliptin was of high cost and T. Glimepiride being the low cost. Using WHO core indicators prescribing patterns were assessed. Feedback was collected and results were reported to the physicians which showed rational utilization of drugs.

Conclusion: The study on drug utilization conducted in a tertiary care hospital helped us to find out that prescribing trends seems to be progressing towards combination therapy, predominantly two-drug therapy
THE IMPACT OF ANTIMICROBIAL STEWARDSHIP ON THE PATTERNS OF ANTIBIOTICS’ PRESCRIPTION AND CLINICAL OUTCOMES IN THE MEDICAL WARD OF A MALAYSIAN TERTIARY CARE HOSPITAL
Authors: SHIRAZI OVAIS ULLAH , RAHMAN NORNY SYAFINAZ AB , ZIN CHE SURAYA , MAHIR HANNAH MD , ADNAN SYAMHANIN
Published: March 2021

Objective: To evaluate the impact of antimicrobial stewardship (AMS) on antibiotic prescribing patterns and certain clinical outcomes, the length of stay (LOS) and the re-admission rate (RR) of the patients treated within the medical ward of a tertiary care hospital in Malaysia.

Methods: This quasi-experimental study was conducted retrospectively. The prescriptions of the AMS included alert antibiotics (AA) such as cefepime, ceftazidime, colistin (polymyxin E), imipenem-cilastatin, meropenem, piperacillin-tazobactam and vancomycin were reviewed for the period of 24 mo before (May, 2012–April, 2014) and after (May, 2014–April, 2016) the AMS implementation for the patients who were treated within the medical ward of a Malaysian tertiary care hospital. Patterns of antibiotics prescribed were determined descriptively. The impact of the AMS on the length of stay (LOS) and readmission rate (RR) was determined by the interrupted time series (ITS) comparative analysis of the pre-and post-AMS segments segregated by the point of onset (May, 2014) of the AMS program. Data analysis was performed through autoregressive integrated moving average (ARIMA) Winter Additive model and the Games-Howell non-parametric post hoc test by using IBM Statistical Package for Social Sciences version 25.0 for Windows (SPSS Inc., Chicago, IL, USA).

Results: A total of 1716 prescriptions of the AA included for the AMS program showed that cefepime (623, 36.3%) and piperacillin-tazobactam (424, 24.7%) were the most prescribed antibiotics from May 2012 to April 2016. A 23.6% drop in the number of the AA prescriptions was observed during the 24-month post-AMS period. The LOS of the patients using any of the AA showed a post-AMS decline by 3.5 d. The patients’ LOS showed an average reduction of 0.12 (95% CI, 0.05–0.19, P=0.001) with the level and slope change of 0.18 (95% CI, 0.04–0.32, P=0.02) and 0.074 (95% CI, 0.02–0.12, P=0.002), respectively. Similarly, the percent RR reduced from 20.0 to 9.85 during the 24-month post-AMS period. The observed post-AMS mean monthly reduction of the RR for the patients using any AA was 0.38 (95% CI, 0.23–0.53, P<0.001) with the level and slope change of 0.33 (95% CI, 0.14–0.51, P=0.02) and 0.37 (95% CI, 0.16–0.58, P=0.001), respectively.

Conclusion: The AMS program of a Malaysian tertiary care hospital was a coordinated set of interventions implemented by the AMS team of the hospital that comprised of the infectious diseases (ID) physician, clinical pharmacists and microbiologist. The successful implementation of the AMS program from May, 2014 to April, 2016 within the medical ward resulted in the drop of the number of AA prescriptions that sequentially resulted in the significant (P<0.05) post-AMS reduction of the LOS and the RR.
DESIGNING AND IMPLEMENTATION OF A SECURITY SYSTEM VIA UML: SMART DOORS
Authors: Jasim Yaser A. , Alsaaigh Mustafa O. , Saeed Mustafa G.
Published: March 2021

Companies or estate have problems stealing employees of items or records by using common keys because the usual key is less reliable. This paper seeks to control intelligent doors by means of a RFID card. In addition, a security system was created for employee entrances and exits with a system-specific server and may allow staff to open a particular door and specify a time for RFID card operation. The design and implementation of a robust and intelligent system were thus designed to control an employee's or a person's entry and exit through the use of an intelligent key and smart doors. This paper proposes the safety improvement plan based on the Smart Door Lock System for the security problem caused by the physical key in unmanned automation machines, like ATMs, KIOSKs and sales machines. The use of hardware and software inventions to construct this program was an effective factor.
Inscripciones callejeras en tiempo de malestar: un análisis etno-semiótico de imágenes del estallido social en Chile
Authors: Le Bert Juan , Soto Maximiliano
Published: March 2021

La práctica de caminar es un acto de interacción que estimula nuestros sentidos de percepción y que nos ayudan a leer la ciudad. Si nos concentramos particularmente en el sentido de la vista, podemos reconocer etnográficamente las marcas inscritas sobre muros, monumentos, esquinas, semáforos, estaciones de metro. Diferentes marcas escriturales que, a modo de contexto, dan cuenta de eventos asociados al estallido social vivido en Santiago, Chile, durante los últimos meses del 2019. De hecho, al caminar por las calles de Santiago podemos observar múltiples marcas que nos interpelan, imágenes y frases que, en síntesis, transmiten el fin de un proyecto histórico, o la sensación de un malestar social acumulado por muchas décadas, y definido colectivamente como el malestar de vivir bajo una subjetividad liberal que se manifiesta desde una comprensión de normalidad asociada a estilos de vida. El presente artículo, que se encuentra en progreso, tiene el objetivo de visibilizar el cuestionamiento de esta normalidad mediante una lectura etnosemiótica, la cual busca decodificar los signos y estilos que le dan cuerpo a los múltiples mensajes que expresan el malestar general de la sociedad frente a un estilo de vida identificado con el “modelo neoliberal”, y que se proyectó en cada una de las fotografías que tomamos durante el período del estallido social, en los entornos cercanos a la “Plaza Italia-Baquedano-Dignidad” en Santiago, Chile.
A propósito de la economía libidinal capitalista
Authors: Paláu Castaño Luis Alfonso
Published: March 2021

Traducción del francés al español de Luis Alfonso Paláu-Castaño

«Evidentemente no quiero decir que no hay diferencia entre el bien y el mal, y que el bien no es nada, como el mal. Muy por el contrario, lo que quiero decir es que esta diferencia es una composición y no una oposición. Ahora bien, la metafísica reposa, por regla general, en oposiciones y engendra siempre, al mismo tiempo, dogmas. Este dogmatismo puede ser religioso, fundado sobre una religión revelada, y conservador. O también puede ser revolucionario y “progresista”, o aún liberal en el sentido de neoliberal. El dogma consiste, entonces, en perseguir toda ambición de una política pública y de una mutualización de las inversiones distintas a las fundamentadas en el provecho a corto plazo. Esto conduce ineludiblemente a que este neoliberalismo niegue de hecho toda diferencia entre el bien y el mal, y a imponer el reino de las pulsiones mientras habla en nombre del bien, dogmáticamente opuesto al mal.»
Nutrient management practices for improved crop and water productivity, grain quality and energy productivity of promising rice cultivars in Eastern Himalayas
Authors:   Division of Agronomy, ICAR-Indian Agricultural Research Institute, New Delhi-110 012, India, Harish M.N. , Choudhary A.K. ,   Division of Agronomy, ICAR-Indian Agricultural Research Institute, New Delhi-110 012, India, Singh Y.V. ,   Division of Microbiology, ICAR-Indian Agricultural Research Institute, New Delhi-110 012, India, Pooniya V. ,   Division of Agronomy, ICAR-Indian Agricultural Research Institute, New Delhi-110 012, India, Das A. ,   ICAR-Research Complex for North-Eastern Hill Region, Barapani-793 103, India, Babu S. ,   ICAR-Research Complex for North-Eastern Hill Region, Barapani-793 103, India, Dass A. ,   Division of Agronomy, ICAR-Indian Agricultural Research Institute, New Delhi-110 012, India, Varatharajan T. ,   Division of Agronomy, ICAR-Indian Agricultural Research Institute, New Delhi-110 012, India
Published: March 2021

Aim: To assess the influence of nutrient management practices on crop and water productivity, grain quality, energy productivity and profitability in promising rice genotypes of Eastern Himalayas. Methodology: An experiment was conducted at ‘Lowland Research Block’ of ICAR–RC–NEHR, Barapani, Meghalaya to assess the influence of different nutrient management practices [Organic nutrient management (through FYM + remaining P through rock phosphate); integrated nutrient management (INM) (50% NPK through fertilizers + 50% N through FYM + remaining P through rock phosphate); inorganic nutrient management (fertilizers); and absolute control] and rice varieties [Shahsarang–1, Lumpnah and Megha semi-aromatic–2] on productivity, quality, energetic and profitability replicated thrice in a split-plot design. Results: Rice grain yield was significantly higher in INM practice (4.18 t ha-1) followed by inorganic (4.02 t ha-1) and organic practice (3.74 t ha-1). INM practice exhibited highest hulling (68.6%), milling (59.9%), head-rice recovery (53.6%), protein content (7.56%) and protein yield (329 kg ha-1) followed by inorganic, organic practice and control, respectively. However, gross and net returns and B: C ratio were significantly greater in inorganic practice followed by INM practice. Highest TWUE (3.17 kg ha-1 mm-1), water productivity (47.6 INR ha-1 mm-1), energy output (140342 MJ ha-1) as well as net energy (130813 MJ ha-1) were recorded in INM practice. Interpretation: INM practice and rice variety ‘Shahsarang–1’ can be recommended to farmers for enhancing the rice productivity, profitability, resource-use efficiency and soil health in eastern Himalayan region of India. Key words: Energetics, Grain quality, Integrated nutrient management, Rice varieties, Water-use efficiency
MOTION CONTROL ANALYSIS OF TWO COLLABORATIVE ARM ROBOTS IN FRUIT PACKAGING SYSTEM
Authors: Dewi Tresna , Anggraini Citra , Risma Pola , Oktarina Yurni , Muslikhin Muslikhin
Published: March 2021

As robots' use increases in every sector of human life, the demand for cheap and efficient robots has also enlarged. The use of two or more simple robot is preferable to the use of one sophisticated robot. The agriculture industry can benefit from installing a robot, from seeding to the packaging of the product. A precise analysis is required for the installation of two collaborative robots. This paper discusses the motion control analysis of two collaborative arms robots in the fruit packaging system. The study begins with the relative motion analysis between two robots, starting with kinematics modeling, image processing for object detection, and the Fuzzy Logic Controller's design to show the relationship between the robot inputs and outputs. The analysis is carried out using SCILAB, open-source software for numerical computing engineering. This paper is intended as the initial analysis of the feasibility of the real experimental system.
"Esquina do Mundo", a quarentena de um hospital de cuidados paliativos
Authors: Sant’anna Denise Bernuzzi , Salman Manuela Samir Maciel , Maciel Maria Goretti , Pelbart Peter Pál , Salman Samir
Published: March 2021

Esta é a transcrição da conversa sobre o filme "Esquina do Mundo". Esta conversa mergulha em reflexões coletivas e meditações de processos de cuidado radical em um hospital de cuidados paliativos em São Paulo, Brasil, dentro da atual crise covid-19. Investiga formas de resistência transversal na ecologia de uma instituição como um hospital e descreve algumas das práticas que são implementadas em conjunto com a enfermagem, como práticas criativas.AbstractThis is the transcript of the conversation/presentation about the film "Esquina do Mundo" (World's corner). This conversation dives around collective reflections and meditations of processes of radical care at a palliative care hospital in São Pau-lo, Brazil, within the current covid-19 crisis. It investigates forms of transversal resis-tance within the ecology of an institution such as a hospital, and describes some of the practices that are implemented together with nursing, such as creative practices.
REPRESENTAÇÕES SOBRE A ESCRITA CIENTÍFICA EM VÍDEOS DO YOUTUBE
Authors: Bessa José Cezinaldo Rocha , Silva Nara Karolina de Oliveira
Published: March 2021

Partindo da necessidade de se problematizar questões relacionadas à leitura e à escrita no ensino superior no contexto das tecnologias digitais, este artigo objetiva analisar representações acerca da escrita científica expressas em vídeos do YouTube. Assumindo um olhar interpretativo e uma abordagem qualitativa, o trabalho centra-se no exame de dois vídeos do canal do Youtube “TCC Sem Drama” destinados a apresentar orientações sobre como escrever artigos científicos. A fundamentação teórica compreende ideias de pensadores e comentadores do Círculo de Bakhtin e trabalhos de estudiosos que abordam a escrita científica em perspectiva enunciativa e/ou sociorretórica. A análise aponta que a escrita científica é significada, nesses vídeos, como um produto com estrutura fixa, homogênea e generalizável, a ser apreendida por um conjunto de técnicas concebidas para cumprir, dentro de um espaço de tempo reduzido, uma mera tarefa/obrigação acadêmica.
(RE)PENSANDO A LEITURA NA EDUCAÇÃO DE JOVENS E ADULTOS: POR UMA PRÁTICA LETRADA
Authors: Sousa da Silva Itana , Campos Lucas  Santos
Published: March 2021

Este trabalho tem como objetivo discutir o processo de leitura na Educação de Jovens e Adultos (pós-alfabetização) buscando compreender o que é ler, quais os focos dessa prática e sua relevância para o público da Educação de Jovens e Adultos (EJA). Refletimos sobre a necessidade de ressignificação do conceito de leitura com o intuito de ampliarmos nossas concepções e (re)pensarmos nossas práticas cotidianas em sala de aula possibilitando a formação de leitores para uma prática letrada que os tornem capazes de interagir usando a linguagem de diferentes maneiras em diferentes ações e em diferentes grupos, sejam eles sociais, culturais etc. Realizamos um breve histórico da EJA nos apoiando nos estudos de Arroyo (2005); tomamos por base os conceitos de leitura trazidos por Arroyo (2005), Kleiman (1999, 2013), Silva (1999, 2002), Soares (2003) e pelos Parâmetros Curriculares Nacionais (PCN) (1998); e por fim, nos apoiamos em Kleiman (1998, 2005), Silva 1999), Soares (1998), e Rojo (2009) para tratar do letramento. Mantendo como proposta (re)pensar a leitura nas turmas de Educação de Jovens e Adultos percebemos que o processo de formação de leitores nesta modalidade de ensino será mais prazerosa e significativa e, consequentemente, obterá melhores resultados se forem levados em consideração os contextos sócio-históricos em que estes sujeitos estão inseridos.
“POR FORA – VIU NO ESPELHO – ELA ERA UMA COISA SECA COMO UM FIGO SECO": BELEZA E IDENTIDADE CAMBIANTE EM UM CONTO DE CLARICE LISPECTOR
Authors: Gervason Defilippo Juliana , Ribeiro Helaine
Published: March 2021

O presente artigo propõe uma leitura do conto A procura de uma dignidade de Clarice Lispector, segundo a perspectiva de que é possível identificarmos a maneira como a personagem se forma a partir da valorização da beleza, ilustrando a predominância da estética por meio do uso da maquiagem, da moda e demais artifícios de embelezamento, seja para se mascarar ou para se transformar em mulher mais atraente. No entanto, quando esta mulher se descobre sem maquiagem ou acessórios, a partir da real percepção do ser e de seu interior, ocorre uma libertação que lhe machuca, levando-a a uma crise de identidade. Este estudo sinaliza, portanto, que a beleza no tocante ao espaço literário não pode ser vista como mera futilidade, mas sim como elemento formador. Vislumbramos, no conto em cotejo, o empenho em ser bela, em demonstrar à sociedade uma imagem que não traduz verdadeiramente o seu eu interior. Clarice, deste modo, realiza uma crítica à cultura patriarcalista da época, desconstruindo os estereótipos moldados pelo modelo falocêntrico. Há, portanto, na personagem do conto, a incerteza em ser aquilo que a sociedade patriarcalista dela espera (no que concerne a comportamento e beleza) e o que no seu íntimo interior ela deseja ser na realidade. O presente artigo surge, então, com o intuito de contribuir com reflexões acerca do modo como ocorre, na Literatura clariceana, o rompimento com a máscara forjada às personagens cambiantes. Deste modo, suas personagens suscitam reflexões relativas à figura feminina enquanto sujeito singular e integrante da sociedade.
LIVRO SOBRE NADA: PRETEXTO PARA INOPEROSIDADE NO TEMPO-ESPAÇO
Authors: Costa Valdegilson da Silva , Bastazin Vera
Published: March 2021

Este artigo analisa o projeto literário de Manoel de Barros em Livro sobre nada (1996), obra cuja nota introdutória, em prosa poética, denominada Pretexto, propõe-se a atingir significações silenciadas e, simultaneamente, ampliadas, posto que, via silêncio, os significados se desalojam de convenções e adquirem sentidos em plena incompletude, por isso, adotamos como metodologia a análise da nota introdutória da obra, em que o artifício adotado pelo poeta para “atingir o nada mesmo”, ampara-se no conceito de inoperosidade, proposto por AGAMBEN (2018), de acordo com o qual a potência-de-não é a amplitude contemplativa e, simultaneamente, uma reação à obrigatoriedade de dizer. Livro sobre nada coloca em suspensão a função comunicativa da linguagem verbal e edifica a crise da palavra, por isso, age de forma a transformar, substancialmente, a realidade via discurso poético, pois sua ação é a busca por aquilo que está por vir na obra, por uma matéria que se anuncia, mas não se consolida, a exemplo do que propõe BLANCHOT (2005), de que resulta um inacabamento que cala aquilo mesmo que se profere por meio de imagens que atravessam o sujeito lírico sob forma de resquícios espácio-temporais.
AS HISTÓRIAS EM QUADRINHOS COMO FENÔMENO LITERÁRIO: PROBLEMAS, IMPASSES E DESAFIOS
Authors: Duarte Renan , `Pires da Silva Anderson
Published: March 2021

Este trabalho tem como intenção discutir questões suscitadas pelo entendimento das histórias em quadrinhos como fenômeno literário. A princípio, buscamos compreender como as HQs se aproximaram do campo da literatura, considerando as proposições de Eisner (1989) sobre narrativas dos quadrinhos como arte sequencial e a popularização da ideia de romance gráfico. Discutimos então, a partir de teóricos como Beaty (2012), Hatfield (2010) e Groensteen (2015), sobre as tensões que emergem no campo teórico, entre a definição de quadrinhos como literatura ou arte visual, e os impasses causados pela busca de prestígio, além de questões sobre o próprio campo dos estudos sobre quadrinhos como uma disciplina própria.
ALFABETIZAÇÃO EM TEMPOS DE PANDEMIA: PERSPECTIVAS PARA O ENSINO DA LÍNGUA MATERNA
Authors: Ferreira Lucimar Gracia , Gracia Ferreira Lúcia , Zen Giovana Cristina
Published: March 2021

Este artigo pontua aspectos desse novo momento que estamos vivenciando – da pandemia da COVID-19 – e a situação da educação nele, principalmente no que diz respeito a alfabetização, isto porque entendemos que alfabetizar é ensinar uma língua, a materna. Desse modo objetivou analisar as alternativas encontradas pelas professoras alfabetizadoras para oferecer as condições necessárias para a apropriação da leitura e da escrita no ERE. Para respondê-lo, realizamos uma pesquisa qualitativa e exploratória a partir da entrevista com três professoras alfabetizadoras de uma escola privada de um município baiano. Assim, foi instituído a adoção da educação remota para que o processo de escolarização continuasse a se concretizar devido a não recomendação de contato físico e foi orientado como esta poderia ocorrer. Neste estudo, refletimos sobre as limitações existentes no processo de alfabetizar remotamente, a partir de referencial bibliográfico existente e das narrativas das docentes que apontam dificuldades com as limitações do Ensino Remoto Emergencial para socialização, aspectos da leitura, escrita e contam, para concretização de ensino, principalmente, com os familiares dos alunos. Consideramos que o estudo em questão potencializa reflexões sobre o tema e pondera modos de saber-fazer dessa fase da escolarização tão específica.