bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigating entrance channel influences in the fusion of some heavy–ion systems
Authors: Girma Asnake , Fessahatsion Amanuel
Published: March 2021

The dynamics of heavy-ion fusion reaction involved in the interaction of 12C,14N and 16O projectiles with,59Co, 51V,128Te and165Ho targets at≈3-8MeV/nucleon speciﬁc energies was studied. This study focus on the correlation between entrance channel properties and incomplete fusion reaction. The experimentally measured excitation functions of various reaction products populated by complete and/or incomplete fusions of 12C+59Co, 128Te,14N+128Teand 16O+ 51V, 165Hoprojectile-target systems available in the literature. Were compared and analyzed with the predicted excitation functions, using the statistical model code PACE4. For representative non-α-emitting channels, the experimentally measured excitation functions were, in general, found to be in good agreement with the theoretical predictions. However, for α-emitting channels in the present systems, the measured excitation functions were higher than the predictions of the theoretical model code, which may be credited to incomplete fusion reactions at these energies. An attempt was made to approximate the incomplete fusion fraction that explains the relative importance of incomplete fusion processes. The incomplete fusion fraction was found to be sensitive to the projectile energy and mass-asymmetry of the entrance channel
Analysis of drying operation and quality evaluation of crushed meat prepared from three trims of low beef marketing
Authors: Gregorio Lopez Pollorena , Hernandez Ariana Sainz Melissa , Hernandez Grace Erandy Baez , Gamez Luque Monica
Published: March 2021

The objective of this research was to evaluate the performance and quality of three cuts of beef marketing low during the drying process for the preparation of meat crushes. quality (color, pH, aw, chemical composition) of beef cuts glove, neck and lizard cool and their behavior during drying (curves) and the quality of the finished product (color, pH, aw analyzed, chemical composition). Data were evaluated by analysis of variance via. Color and aw in the raw material were within the normal range, while the pH was varied from 5.92-6.45. In the chemical composition, the cut glove had higher moisture content (76.42%). Similarly, during drying, this cut, introduced least resistance for water removal, reaching the desired humidity (25-30%) in less time (240 min). With regard to the finished product, differences in physicochemical characteristics, mainly in color they were presented. The chemical composition, both moisture and protein were affected, which varied between the 24.65-28.09% and 51.70-53.65% respectively. The three cuts have assessed potential for the production of dried meat products, such as crushed and dried meat
Endotracheal Cardiac Output Monitoring (ECOM)
Authors: Chandrasekhar Vijayalakshmi , krishnamurti Chandrasekhar
Published: March 2021

Cardiac output reflects the amount of blood expelled by the heart in one minute and calculated as the product of the heart rate by the stroke volume. The variables that affect systolic volume are preload, afterload, and contractile function. Cardiac output is the main determinant of oxygen transport and its monitoring helps to establish the differential diagnosis of the possible causes of shock and optimizes its treatment. A less invasive technique to monitor cardiac output in real time is always preferable as it can be evaluated more quickly and easily, even if it is slightly less accurate, especially in critical situations that require a rapid assessment of the patient’s condition. There are a number of techniques that allow us to obtain measurements of cardiac output in a very effective and non-invasive way. The endotracheal cardiac output monitoring (ECOM) is an emerging technology for intubated patients enabling rapid real time and accurate data on the status of the cardiac output and various derived parameters. ECOM is poised to be the new gold standard in critical care management and an emerging toll in the armamentarium of intensivists.
The perioperative application of High Flow Nasal Cannula: a single center experience
Authors: A. Hilmi Ibtesam , C. Carullo Philip , P. Phillips Dennis , Abuelkasem Ezeldeen
Published: March 2021

The physiologic benefits of high-flow nasal cannula (HFNC) therapy are well documented in the intensive care literature, yet only a handful of case reports describe its perioperative use. Our single center experience explored comprehensive applications of HFNC in the perioperative setting. Over a ten-month period, HFNC was used in the care of 85 medically complex patients either as an adjuvant or main oxygen therapy during induction of general anesthesia, maintenance of deep intraoperative sedation, and during early postoperative care. Here, we illustrate clinical scenarios in which HFNC therapy made patient care safer and describe a framework for integrating this technology into the anesthesia practice at our institution.
A prospective randomised double blinded comparative study between nasal atomized dexmedetomidine and midazolam as premedicants in paediatric adenotonsillectomy
Authors: Philip Shoba , Jacob Suria
Published: March 2021

Adenotonsillectomy is one of the most common ambulatory surgeries in the pediatric population. Fear and anxiety at parental separation is one of the important challenges to the anesthesiologist in spite of improvements in the drug armamentarium, seen in 40-60% children. The gold standard of premedication is Midazolam, which is effective by all routes, intravenous, intramuscular, oral, submucosal and nasal.1,2 Nasal Midazolam is commercially available, each puff delivering 0.5mg. Nasal route is now being popular because it is non-invasive, easy and has rich blood supply which ensures a faster absorption and faster onset of action. Besides, it bypasses the hepatic metabolism, so bioavailability is improved from 40-60% in oral route to about 82% in nasal route. The search for ideal premedicant continues3 and Dexmedetomidine, alpha-2 agonist, is the new kid in town. It is effective by all routes including nasal.3 But, so far only studies with nasal instillation of Dexmedetomidine, is available, especially in children. Syed et al. in 2019 has used atomized form of Dexmedetomidine in adults for minor orofacial procedures. Hence we decided to compare nasal atomized Dexmedetomidine and Midazolam using atomization devices like LMA MAD NASAL and INSED ATOMISER because atomization helps to break down particle to 30-100microns, hence absorption would be quicker with minimum or no side effects.
Management protocol for the naltrexone implant in the patients with acute abstinence symptoms: Mexican case series
Authors: Ornelas Guillermo Aréchiga , Fajardo Pérez Mario , Flores Jorge Bonilla , Santoyo Cueva Ana Karen , Bucio Cedeño Diana Romina , Garza Garibay Carlos , Rodriguez Stephanie Victoria Gomez , Rodriguez Juan Orlando Castillo , Vega Perálta Melissa , Cornejo Huerta Ana Karen , Cuevas Rocío Valenciano , Navarro Rojas Ramón Jayme , Longoria Robledo Armando , Altinpulluk Ece Yamak
Published: March 2021

Abuse and addiction to opioids, including prescription painkillers, heroin and synthetic opioids such as fentanyl, buprenorphine, constitute a serious crisis that affects public health and has economic repercussions.1 Naltrexone implants are effective tools used in hospital environments and they can not only save patient´s lives but also maintain a prolonged effect, free of relapse and with better therapeutic adherence. The aim of this study is to describe that the management protocol of acute abstinence symptoms in patients with a history of opioid use prior to naltrexone implant placement.
Develop a validated anesthesia quality assessment to evaluate patients postoperatively
Authors: Amornyotin Somchai , Parakkamodom Sudta , Vichitvejpaisal Phongthara , Noitasaeng Papiroon , Udompunturak Suthipol
Published: March 2021

Objective: The study is aimed to develop a well-validated anesthesia quality assessment to evaluate patients postoperatively. Materials and Methods: After securing Institutional Review Board approval, the study was registered via ClinicalTrials.gov (NCT 0307996). The Siriraj Anesthesia Quality Assessment Questionnaire was developed and validated under the conceptual/theoretical framework of Maslow’s hierarchy of needs, Hospital Consumer Assessment of Healthcare Providers and System, Patient Satisfaction Questionnaire, Service Quality Questionnaire and Quality of Recover after Anesthesia. A total of 476 qualified responses with obtained consent were included in the study to verify the appropriateness of the tool. Results: The study involved 397 qualified patients (83.4%), aged 47.6±16.6, representing all anesthesia services. Significantly, a binary logistic regression revealed the predicted dependent variables as Process of Care (4.39±0.51) and Physical Support (4.35±0.66) in comparison with a sequence of Accessibility and Convenience (4.33±0.56), Communication and Information (4.00±0.70), Technical Quality (4.46±0.45) Psychological Support (4.57±0.65) and Loyalty (4.52±0.68) in anesthesia quality assessment. Conclusion: Process of Care and Physical Support appeared to be significantly valued features, whereas Communication and Information, Accessibility and Convenience, Technical Quality and Psychological Support were found to be weak points in anesthesia quality assessment.
Rare dermoscopic image of the "sarcopte" in a new born
Authors: Asmae Rasso
Published: March 2021

A 40-day-old new born, from a non-consanguineous marriage, the mother reports the concept of normal pregnancy, medicalized vaginal delivery with good adaptation to ectopic life. Parents present in the emergency due to agitation, and lesions on the body level in their baby. The dermatological examination showed pustules and seropapules diffuse on the body level, scalp and palmar plantar, and a background of erythema.
Papular amyloidosis and leonine facies: about two cases
Authors: Achehboune Kaoutar
Published: March 2021

apular amyloidosis or amyloid lichen is a form of localized skin amyloidosis potentially rare. Its mechanism is poorly known. There are localized and hereditary systemic and cutaneous forms. Papular amyloidosis is a form of localized cutaneous amyloidosis. It is manifested by papules, fleshy or brown, smooth or very hyper-keratotic, very pruriginous, simetric and sitting electively on the anterior surfaces of the legs and extending to the calves and back of the feet, often excoriated by the intensity of scraping. Leonin facies can be observed in systemic amyloidosis but it has not been described in lichen amyloid. We report 2cases of this association.
Proof of concept simple conductive thread stitch sensor to measure the duration of kangaroo care
Authors: Clarke-Sather Abigail , Weber Michael J , Cobb Kelly , Naylor Lindsay
Published: March 2021

Throughout the world thousands of infants are born each day according to the World Health Organization. All infants can benefit from the use of Kangaroo Care (KC) or bare skin-to-skin contact between caregiver and infant. One of the key principles to getting the most from KC is that is must be performed for at least one hour according to the World Health Organization. Yet, the duration of KC is rarely measured. This study explores the use of a simple device, a conductive thread stitch sensor coupled with a pair of magnets and a microcontroller, to measure the duration of KC automatically. For this study, a single subject used the sensor with a specific KC garment and performed KC with a weighted doll. It was determined, that when comparing manual timed values of the duration of KC to the sensor values, there was 6.43±5.67% average percentage difference. This proof of concept shows that this simple device can be used to determine the duration of KC in an effective manner.
Impact of hysterectomy on uterine cancer incidence rates in Egypt
Authors: Soliman Amr S , Alshahrani MD PhD Saad , Chamberlain PhD Robert M , Hablas MD Ahmed , Remmenga MD Steven , Meza Jane L , Seifeldin MD Ibrahim A , Ramadan MD Mohamed , Murray MPH Mariah
Published: March 2021

Background: Uterine cancer is one of the common women’s cancers worldwide. There are significant variations in uterine cancer incidence rates globally and the incidence in Egypt is one of the lowest. Several studies have shown that hysterectomy might be a factor in underestimating the observed incidence of uterine cancer. However, no studies have been conducted in Egypt to examine this observation. Methods: Pathologic reports of all 1040 hysterectomy specimens examined in 2013 and 2014 in the Gharbiah province, Egypt were abstracted. Prevalence of hysterectomy was estimated and used for adjusting the incidence rate of uterine cancer in the Gharbiah population-based registry by excluding the hysterectomized women from the population at risk. Pre- and post- adjustment rates were compared and 95% confidence intervals (CIs) were calculated. Results: The prevalence of hysterectomy was estimated as 13.1 per 10,000 women, 95% CI (12.65-13.66). The prevalence of hysterectomy did not have a significant impact on uterine cancer incidence [pre-adjustment (2.78, 95% CI 2.58-3.00) and post-adjustment (2.79, 95% CI 2.58-3.00)]. Observing a significant effect of hysterectomy on underestimating the incidence of uterine cancer in this population required multiplying the observed prevalence by at least 110 times. Discussion: This study confirmed the previously documented low incidence of uterine cancer in this population of Egypt. The lack of evidence about the possible role of hysterectomy in lowering uterine cancer incidence justifies the need for additional research to identify the protective factors for uterine cancer in this population.
Severe recurrent ascites in a Pseudo-Meigs’ syndrome variant
Authors: Al-Mshhdani MD Ayser , Payá Ten MD Claudia , To MD, FACOG Justin
Published: March 2021

Background: Meigs’ syndrome is the triad of ovarian neoplasm, ascites and pleural effusion, while Pseudo-Meigs’ syndrome is the presence of ascites and pleural effusion with other pelvic tumors. Ascites resolves after tumor resection. Our case does not meet classic criteria for either but is likely a variant of Pseudo-Meigs’ syndrome. Case: A 30-year-old female had multiple Emergency Department visits for abdominal pain, distention, and shortness of breath. Imaging showed severe abdominal ascites with a large leiomyomatous uterus but no pleural effusions. Multiple paracenteses revealed benign cytology. After counselling, she underwent an abdominal myomectomy which resolved her recurrent ascites. Conclusion: Variants of Pseudo-Meigs’ syndrome should be considered in the differential of abdominal pain and leiomyomas with ascites, and surgical management should be offered.
Operational analytics as a data monitoring and event management tool of the cyber security management systems
Authors: Kachynskyi A.B. , Stremetska M.S.
Published: March 2021

With growing demand for the digitalization of data collection, transmission, processing and storage processes in all life spheres of individual, society, and state, there is an urgent need to construct an infrastructure of information transmission networks which can provide a secure connection between endpoints and data centers. These networks must have high availability and provide the fast and efficient processing of information requests, especially in case of critical infrastructure networks. A structural functional scheme of data management for SIEM systems which includes straight and reverse relations between physical, mathematical and analytical levels is proposed, based on the stratum theory by M. Messarovich. A model of multilevel system for the data monito ring and cyber security event management is built in order to provide a systematic approach to maintain the safety state of complex systems and to ensure mechanisms for the operative real-time cyber security incident response.
Stability kernel of vector optimization problems under perturbations of criterion functions
Authors: Lebedeva Т.Т. , Semenova N.V. , Sergienko T.I.
Published: March 2021

The article is devoted to the study of the influence of uncertainty in initial data on the solutions of optimization multicriterial problems. In the optimization problems, including problems with vector criterion, small perturbations in initial data can result in solutions strongly different from the true ones. The results of the conducted researches allow us to extend the known class of vector optimization problems, stable with respect to input data perturbations in vector criterion. We are talking about stability in the sense of Hausdorff lower semicontinuity for point-set mapping that characterizes the dependence of the set of optimal solutions on the input data of the vector optimization problem. The conditions of stability against input data perturbations in vector criterion for the problem of finding Pareto optimal solutions with continuous partial criterion functions and feasible set of arbitrary structure are obtained by studying the sets of points that are stable belonging and stable not belonging to the Pareto set.
On construction of the control that provides the desired trajectory of the movement of the single-link manipulator with elastic joint
Authors: Khoroshun A.S.
Published: March 2021

The law of rotation of the electric motor, which ensures a global asymptotic direction of the trajectory of the model of a single-link manipulator with an elastic joint to a given program trajectory is obtained The elasticity of the joint is modeled by a torsion spring, the elastic force of which is considered to be nonlinearly dependent on the displacement. This fact makes it impossible to apply the usual approach and greatly complicates the task of control construction. The fact that some parameters of the model can be uncertain and, in some way, depend on some numerical parameter, the area of change of which is unknown in advance, also adds complexity. However, the use of DSC (Dynamic Surface Control) technique allows us to get the desired control. The development of the DSC technique, which consists in a specific choice of parameters and constants of filters, is proposed. It avoids the growth of the order of the auxiliary system, as well as a significant complication of the form of both the auxiliary system of differential equations and the control law, the so-called “explosion of terms”. It allows us to obtain explicitly the corresponding auxiliary function and to prove that the proposed control law solves the control problem. The robustness of such control is also proved, and the region of robustness in the system parameters space is defined. The obtained results are illustrated by the example of a mechanical model.
Succinic acid derivatives: influence on the metabolic factors of the development of fatigue and working capacity under physical loads
Authors: Gunina L.M. , Voitenko V.L. , Nosach E.V.
Published: March 2021

A study has been carried out on the effect of the domestic pharmacological armadin long preparation (2-ethyl- 6-methyl-3-hydroxypyridine succinate) on the physical working capacity of athletes under the maximum intensity force loads characteristic of modern sports. Since pharmacology in sports is constantly searching for non-toxic drugs of the metabolithotropic origin that would have the ability to promote physical efficiency and slow down fatigue without toxic effects on the body, we have chosen for our research a drug based on succinic acid, which is a natural metabolite of the Krebs cycle. It has been shown that the armadin long preparation, when applied on a course for three weeks, positively affects the parameters of special working capacity associated with the improvement of the oxygen-transport function of blood. The metabolic basis of this phenomenon is the inhibition of a decrease in the pH of the internal environment of the body with the subsequent development of lactate-acidosis and the ability of the armadin long drug to accelerate the processes of angiogenesis, and, accordingly, the transport of oxygen to the athlete’s working muscles. The intensity of the formation of new growth factor (VEGF). Such data substantiate the expediency of the use of succinic acid-based agents to prevent negative metabolic changes and to slow down the onset of fatigue in athletes under intense physical loads.
The knowledge of chromosomal sex is important for large-scale analysis of gene expression
Authors: Lykhenko O.K. , Obolenskaya M.Yu.
Published: March 2021

The aim of the study was to determine the sex of the fetus in gene expression data lacking this information using expression of the Y-linked genes, and to elucidate the difference between sex-chromosomal-linked gene expression between placental samples with XX and XY genotypes during pregnacy. We have detected 27 differentially expressed sex-chromosomes-linked genes. We have shown that, in most cases, the expression of genes from X-chromosomes in pregnancy carrying baby girls is higher than in pregnancy carrying baby boys, but there are exceptions to this pattern, which must be taken into account in large-scale studies of gene expression. The nature of the difference in gene expression during pregnancy carrying baby girls and boys (positive or ne gative difference) persists during pregnancy, but the magnitude of the difference may remain unchanged or decrease from the first to the third trimester. Taking sex dimorphism into account when analyzing large-scale gene expression data between trimesters of pregnancy increases the number of differentially expressed genes, which improves the informative value of the study and is important for elucidating the pathogenesis of pregnancy complications associated with placental dysfunction.
Damping efficiency of two-layer polyurethane composites
Authors:   Institute of Macromolecular Chemistry NAS of Ukraine, 48, Kharkivske shose, Kyiv, 02160, Ukraine, Babkina N.V. , Antonenko O.I. ,   Institute of Macromolecular Chemistry NAS of Ukraine, 48, Kharkivske shose, Kyiv, 02160, Ukraine, Kosyanchuk L.F. ,   Institute of Macromolecular Chemistry NAS of Ukraine, 48, Kharkivske shose, Kyiv, 02160, Ukraine, Brovko O.O. ,   Institute of Macromolecular Chemistry NAS of Ukraine, 48, Kharkivske shose, Kyiv, 02160, Ukraine
Published: March 2021

In this work, based on the results of dynamic mechanical studies, the damping efficiency of two-layer polyurethane (PU) composites designed by gluing two films of synthesized PU with different glass transition temperatures (Tg) was estimated. The damping efficiency was estimated by the parameters of the mechanical losses (tanδ) peak. To vary Tg, three types of PU with different chemical nature and structure were synthesized. The effect of an increase in the difference between the Tg of the initial PU (ΔTg) on the damping efficiency of the two-layer PU composites formed from them is analyzed. The effective damping temperature range (ΔT) was estimated as the temperature range under conditions tanδ ≥ 0,3 and tanδ ≥ 0,6. It was shown that at ΔТg = 7 °С a two-layer PU composite has one relaxation maximum, and its temperature range of damping efficiency expands in comparison with ΔТ for individual PU. Under the conditions ΔТg = 23 °С and ΔТg = 30 °С, two-layer PU composites exhibit damping efficiency in two temperature regions at tanδ ≥ 0,3, which provides an additional temperature range of effective damping. The essential role of the PU structure of each of the layers in the formation of a two-layer composite by gluing has been determined. Easier penetration of residues of the adhesive organic solvent into the surface of the PU film with a linear structure leads to plasticization of the corresponding layer in the composite and reduces Tg. It is shown that a two-layer structure can be used to solve specific problems related to the adjustment or broadening the effective damping temperature range.
Money Supply Model in Muslim Countries
Authors: Suhanda Nanda , Firmansyah Hamdan
Published: March 2021

Efforts to control economic conditions in a country are called monetary policy. The main thing is to regulate the stability of the value of money and the amount of money circulating in the homeland of each country. This macro policy is expected to be able to respond to micro economic growth so that real economic growth will be realized. The economic success of a country is largely determined by the precise determination of monetary policy. This policy was created in response to the microeconomics which was then managed in a macro manner by policy makers. This policy making step must be in accordance with the sharia scenario so that the economic growth is expected to get a blessing so that falah is the ultimate goal of the economy as well as being realized as the policy is taken. A literature review was finally taken in order to find answers to this essential monetary policy concept. The final goal of the discussion of sharia economic policy is to maintain and maintain the stability of the country's economy.
Buy and Selling in the Perspective of Jahiliyah and Islam a Comparison Study a Review of Sharia Economic History
Authors: Ahdi Ahdi , Firmansyah Hamdan
Published: March 2021

Buying and selling or trading in the term fiqh are called al-Ba'i which, according to etymology, means selling or replacing. The word al-Ba'i in Arabic is sometimes used for the understanding of his opponent, namely the word al-Syira (buy). Thus, the word al-Ba'i means selling, but also means buying. In terminology, buying and selling is an agreement to exchange objects or goods that have a good value between the two parties, one receives objects and the other receives them in accordance with an agreement or provision that has been justified and agreed upon. In the Qur'an, there are many statements that describe the life of the Arabs, including trade problems. Islam is very concerned about the problem of trade in this Arab nation by setting for them what they need. Many of the Prophet's hadith mention the legal issues of buying and selling, monopoly, accounts payable, profits, etc. Jahiliyah Arabs have a market as a center of trade. Usury is one type of economic transaction that is actually carried out and developed in Arab society. In Islam, buying and selling if it contains usury, illicit goods, reduces scales, and by force.
The analysis of research about gifted and talented children at early childhood in Turkey: a study of meta – synthesis
Authors: İNCİ Gamze
Published: March 2021

The objective/aim of this study is to give an analysis of the researches conducted on gifted and talented in the early childhood period in Turkey through the methodology of meta-synthesis, and yet to reveal the tendencies of the scientific studies. This study provides the literature scanning/reviewing for the articles and graduate thesis written in Turkey between the years of 2002 and 2017. 37 scientific studies are included in this study. At choosing the studies, Google Scholars’ search engine, databases of TUBITAK ULAKBIM DergiPark, YOK National Thesis Center, EBSCOhost- ERIC, and SPRINGER are recruited. All the studies which are approached for this study are analyzed through the content analysis for different themes such as years, subjects, working groups, objectives, methods, and outcomes. These categories of the themes present the data and these data are interpreted based on frequency and percentage values. All the theme categories and frequency values are visually shown in tables and graphs. As a result of this study, it is stated that studies on determining the gifted or talented kids in the early childhood period are quantitatively more. It is found interesting that most of the studies have recruited scales and survey methods. Some of the studies on this subject are the articles from the thesis studies. It is revealed that studies focusing on differentiated education programs for the gifted and talented kids in early childhood are minute amount. In accordance with these results, several facts and suggestions related to these facts are discovered such as multi-dimensional measurement methods are needed to be related to identification in Turkey’s early childhood period, identification for the gifted and talented kids in their early childhood period is crucial as well as the education for their parents and teachers due to their health education is needed, it is also needed to develop relevant differentiated education programs related to kids’ talent fields and finally, it is important to create a national education program to be applied to all the departments who are concerned.
Toys for children with the concept of STEM: study of the result from children’s playing activities
Authors: EGWUTVONGSA Songwut
Published: March 2021

This research aimed to examine the result from toy invention with the concept of STEM. The testers comprised 36 people who were the parents and children aged between five to seven years old that used the service of a child development center in Buriram Municipality in Thailand. Additionally, they were selected by purposive sampling that used multiple regression analysis to show the result from the testing of the newly designed toys as the concept of STEM. The results found that the toys had a satisfaction level of the Good (mean=4.333; S.D.=0.652) with the regression equation 𝑌̂ = 0.234 + [0.741 X1] + [0.106 X2] + [0.049 X3] + [0.071 X4] to explain the changing of the level of satisfaction to be 72.73% (r²=0.7273). Research of the playing design as the concept of STEM at this time, Able to meet learning goals based on STEM concepts to an excellent level.
The effects of birth order and family size on academic achievement, divergent thinking, and problem finding among gifted students
Authors: ALSALEH Aseel , ABDULLA ALABBASİ Ahmed , AYOUB Alaa Eldin , HAFSYAN Amnah
Published: March 2021

The current study explored the influence of birth order and family size on academic achievement, divergent thinking (DT), and problem finding (PF) with a sample of 156 gifted male and female Arab students (M= 12.21 years, SD= 1.75). Regarding academic achievement, it was found that first-borns possessed higher grade point averages (GPAs) than did other-born children. Family size was also related to academic achievement-participants from smaller-sized families had significantly higher GPAs compared with gifted students from middle- and large-sized families. As for the influence of birth order and family size on both DT and PF, a multivariate analysis of variance showed significant differences for birth order and the interaction between birth order and family size in the originality dimension of PF. Non-significant differences were found concerning family size. The follow-up analyses of variance showed that later-born gifted students scored higher than first-, second-, third-, and fourth-born children in PF originality. Later-born gifted students who scored higher on originality were from smaller families. No significant influences for birth order and family size were found concerning fluency for both DT and PF as well as DT originality. Limitations and future directions are discussed.
New era for the JEGYS
Authors: TORTOP Hasan Said
Published: March 2021

JEGYS has aimed to combine the gifted education with the science education since first issue. JEGYS continued to develop by creating a new academic field. It brought the concept of "advanced science education" to the academic literature. Now, it presents a series of innovations and developments to its writers and readers in order to keep up with the change in every field in the world. It takes importance the first steps in publishing by updating the principles of strict academic review, broad country participation, visibility and transparency in its editorial policy. In this article, these topics are discussed in details and with examples.
Pseudomonas syringae seed infections v1
Authors: Rooney William , Laird (University of Glasgow) Janet , Chowdhury (University of Glasgow) Mechna , MacIntosh (University of Glasgow) Catriona , Deng (University of Glasgow) Xiaoyi , McBride (University of Glasgow) Phoebe , Milner (University of Glasgow) Joel
Published: March 2021

Seed contamination represents a critical route for the transmission of bacterial plant diseases. Here we have created a step-by-step protocol for in vitro seed infections of Pseudomonas syringae. This protocol provides a robust method for P. syringae infection in cucumber. This synthetic seed infection assay is generally applicable for P. syringae as we have successfully adapted it for both tomato and soybean.
Extraction of flagellum basal body complexes from Buchnera aphidicola, an endosymbiont of aphids v1
Authors: not provided mschepers
Published: March 2021

Buchnera aphidicola is an intracellular bacterial symbiont of aphids and maintains a small genome of only 600 kbps. Buchnera is thought to maintain only genes relevant to the symbiosis with its aphid host. Curiously, the Buchnera genome contains gene clusters coding for flagellum basal body structural proteins and for flagellum type III export machinery. These structures have been shown to be highly expressed and present in large numbers on Buchnera cells. No recognizable pathogenicity factors or secreted proteins have been identified in the Buchnera genome, and the relevance of this protein complex to the symbiosis is unknown. Here, provide a procedure for isolating the Buchnera flagellum basal body proteins from the cellular membrane of Buchnera. This will facilitate studies of the structure and function of the Buchnera flagellum, and its role in this model symbiosis.
Streptococcal protein G and Protein-AG sandwich ELISA v1
Authors: A Justiz-Vaillant Angel
Published: March 2021

This ELISA was used to study the interactions between Staphylococcal protein-G (SpG) and protein-AG (SpAG) with different immunoglobulin preparations from mammalian and avian species.
Peptostreptococcal Protein L and Protein LG sandwich ELISA v1
Authors: A Justiz-Vaillant Angel
Published: March 2021

This ELISA was used to study the interactions between Staphylococcal protein-L (SpL) and protein-LG with different immunoglobulin preparations from mammalian and avian species.
Peptostreptococcal protein L and a Chimeric Protein-LAG sandwich ELISA v1
Authors: A Justiz-Vaillant Angel
Published: March 2021

This ELISA was used to study the interactions between Peptostreptococcal protein-L (SpL) and protein LAG (PLAG) with different immunoglobulin preparations from mammalian and avian species.
Chimeric Protein-LA and Protein LAG sandwich ELISA v1
Authors: A Justiz-Vaillant Angel
Published: March 2021

This ELISA was used to study the interactions between protein LA (SpLA) and protein-LAG (PLAG) with different immunoglobulin preparations from mammalian and avian species.
Chimeric Protein-LG and Protein-LAG sandwich ELISA v1
Authors: A Justiz-Vaillant Angel
Published: March 2021

This ELISA is used to study the interactions between protein-LG (SpLG) and protein-LAG (PLAG) with different immunoglobulin preparations from mammals and avian species.
Chimeric Protein-AG and Protein-LAG sandwich ELISA v1
Authors: A Justiz-Vaillant Angel
Published: March 2021

This ELISA is used to study the interaction between protein-AG (SpAG) and protein-LAG (PLAG) with different immunoglobulin preparations from mammalian and avian species.
Streptococcal Protein-G and Protein-LG sandwich ELISA v1
Authors: A Justiz-Vaillant Angel
Published: March 2021

This ELISA was used to study the interactions between SpG) and SpLG) with different immunoglobulin preparations from mammalian and avian species.
Chimeric Protein-LAG and Peptostreptococcal protein L sandwich ELISA v1
Authors: A Justiz-Vaillant Angel
Published: March 2021

This ELISA is used to study the interactions between protein-LAG (PLAG) and Peptostreptococcal protein-L (SpL) with different immunoglobulin preparations from mammalian and avian species.
Chimeric Protein-LAG and Staphylococcal Protein A sandwich ELISA v1
Authors: A Justiz-Vaillant Angel
Published: March 2021

This ELISA was used to study the interactions between protein-LAG (PLAG) and staphylococcal protein-A (SpA) with different immunoglobulin preparations of mammalian and avian species.
Chimeric Protein-LAG and Streptococcal protein G sandwich ELISA v1
Authors: A Justiz-Vaillant Angel
Published: March 2021

This ELISA was used to study the interactions between protein-LAG (PLAG) and streptococcal protein-G (SpG) with different immunoglobulin preparations of mammalian and avian species.
Chimeric Protein-LAG and Protein-LG sandwich ELISA v1
Authors: A Justiz-Vaillant Angel
Published: March 2021

This ELISA was used to study the interactions between protein-LAG (PLAG) and protein-LG (SpLG) with different immunoglobulin preparations from mammalian species.
Chimeric Protein-LAG and Protein-AG sandwich ELISA v1
Authors: A Justiz-Vaillant Angel
Published: March 2021

This ELISA was used to study the interactions between protein-LAG (PLAG) and protein-AG (SpAG) with different immunoglobulin preparations from mammalian and avian species.
IHC AD neuropathology protocol v1
Authors: Bjorkli Christiana
Published: March 2021

Immunohistochemical processing was conducted on tissue from chronically implanted animals, as well as non-implanted transgenic mice for characterization of AD neuropathology.
Clinical significance of changes in the expression level of markers of surrogate breast cancer subtypes in recurrent and metastatic foci (literature review)
Authors: Krumin Yu. S. , Khaylenko V. A. , Kozlov N. A. , Cheremis G. Yu. , Petrovskyy A. V. , Khaylenko D. V. , Artamonova E. V. , Kovalenko E. I.
Published: March 2021

The article analyzes data from the world literature for the period from 2005 to 2020 on the relationship between the variability of immunohistochemical expression of estrogen and progesterone receptors, HER2/neu protein and the index of proliferative activity in invasive breast cancer with the course of the disease and the response to medication.
Complications after simultaneous prepectoral breast reconstruction using polyurethane-coated implants in patients with breast cancer
Authors: Vlasova M. Yu. , Zikiryakhodzhaev A. D. , Reshetov I. V. , Usov F. N. , Saribekyan E. K. , Shirokikh I. M. , Gerasimov A. N. , Khakimova Sh. G. , Starkova M. V. , Ablitsova N. V. , Tregubova А. V. , Berestok T. S.
Published: March 2021

Background. The development and improvement of reconstructive breast surgery provides medical, psychological and social rehabilitation of cancer patients, allowing them to achieve the best cosmetic and functional results. The trend towards the return of prepectoral reconstruction is associated not only with the improvement of mastectomy techniques, but also with implant coating and the emergence of highly cohesive silicone gel filling of implants. The use of polyurethane-coated endoprostheses in prepectoral reconstruction provides more reliable fixation to the surrounding tissues and allows reconstruction of the mammary glands without additional covering of the endoprosthesis.

Objective: to improve the results of surgical treatment when performing a one-stage reconstruction by pre-rectal placement of polyurethanecoated implants in breast cancer. Materials and methods. In the period from April 2017 to September 2020 at the Department of Oncology and Reconstructive Plastic Surgery of the Breast and Skin of P.A. Herzen Moscow Oncology Research Institute performed 340 prepectoral breast reconstructions (direct-toimplant) using polyurethane-coated implants in breast cancer patients. A group of patients was analyzed (n = 208).

Results. We noted the following complications: prolonged seroma (more than 30 days) in 39 (18.6 %) patients, red breast syndrome in 31 (14.8 %) patients, capsular contracture III–IV degree by J.L. Baker in 43 (20.57 %) patients, protrusion/extrusion of the endoprosthesis in 23 (11 %) patients, suture divergence in 8 (3.8 %) patients, necrosis in 8 (3.8 %) patients, infectious complications in 14 (6.7 %) patients, ripping in 10 (4.8 %) patients. Also, 2 (0.95 %) patients had a violation of the integrity of the endoprosthesis, and 2 (0.95 %) patients had rotation of the endoprosthesis. 

Conclusions. Prepectoral breast reconstruction can be used as an alternative to subpectoral reconstruction in primary operable forms of breast cancer with sufficient thickness of integumentary tissues.
Possibilities of mammography, ultrasound, and MRI in the differential diagnosis of microcarcinomas of various biological subtypes of invasive breast cancer
Authors: Alieva G. S. , Korzhenkova G. P. , Kolyadina I. V.
Published: March 2021

Objective:to study the radiological and sonographic features of microcarcinomas of various biological subtypes.

Materials and methods.The analysis included 59 patients (median age – 55 years) with invasive breast cancer (BC) pT1a–bN0M0 stages at the N.N. Blokhin Russian Cancer Research Center. The frequency of distribution of luminal A, luminal B HER2 negative, HER2 positive (HER2+) and triple negative subtypes of BC was 39 %, 23.7 %, 23.7 % and 6.8 %, respectively. The analysis of key radiological characteristics and sonographic features of microcarcinomas with different biological structures associated with the diagnosis according to the BI-RADS criteria was carried out.

Results.Tumors with luminal A and B subtypes had the most characteristic of malignancy (presence of a node ± microcalcinates), which allowed us to establish the category of BI-RADS 4–5 in mammography (MMG) in 82 % and 88.9 % of patients, respectively. Triple negative cancer is characterized by the presence of a node without microcalcifications; the BI-RADS 4–5 category is exposed in 75 % of cases. Maximum of the difficulties noted in the diagnosis of HER2+ subtype: 4 type density BC (18.2 % of cases), absence of tumor site during surgery in 57.1 % of cases and atypical characteristics of the node (16.7 %) and iso/hypodense structure node (33.4 %) resulted in high frequency of false-negative results in MMG (BI-RADS 0–3 35.7 %), p = 0.049. In addition, HER2+ early BC has proven to be the most difficult subtype for sonographic diagnosis too. The absence of a tumor node in sonography in 14.2 % of cases, as well as its atypical characteristics (iso/hyper echogenicity in 16.7 % of cases and the absence of an acoustic shadow in 18.2 % of patients) led to a high frequency of BI-RADS 0 (21.4 %), which required further examination of these patients.

Conclusions.HER2+ early BC was the most difficult biological subtype for MMG and sonographic diagnostics
Occult breast cancer. Literature review and case series
Authors: Khodorovich О. S. , Solodkiy V. A. , Kalinina-Masri A. A. , Bliznyukov О. Р. , Sherstneva T. V. , Lazukina I. A. , Kanakhina L. B.
Published: March 2021

Background. Currently, there are several forms of breast cancer (BC): nodular, diffuse, edematous-infiltrative, mastitis-like form, as well as Paget’s cancer. A special form of BC is the hidden or occult form. Taking into account the analysis of methods for the diagnosis and treatment of occult BC, it is important that this form of the disease is detected at a later stage. It includes axillary lymphadenopathy and histologically appears to be a metastatic lesion of the lymph nodes from undetectable invasive BC.

Materials and methods. We conducted a thorough analysis of domestic and foreign literature and described two clinical examples with authentic documentation of the results of the examination and treatment. The article describes in detail the schemes of drug treatment and descriptions of the results of morphological examination of the surgical material.

Results. Given the complexity of the diagnostic stage, the clinical form of the course of diseases, the described clinical examples can be attributed specifically to the occult form of BC. An important and determining factor in treatment is the diagnostic stage using all possible methods, including positron emission tomography–computed tomography, breast magnetic resonance imaging and trepan-biopsy of regional lymph nodes, followed by the determination of the molecular biological subtype of the tumor.

Conclusions. In this article, the presented data confirm the general statement about the uniqueness of this disease, which requires a more detailed and multidisciplinary approach at the stage of diagnosis and determination of treatment tactics.
Hereditary breast cancer and ovarian cancer: clinical course and treatment
Authors: Semiglazov V. V. , Protasova A. Е. , Kalikeev G. K.
Published: March 2021

This article analyzes current problems associated with surgical and systemic treatment for hereditary breast and ovarian cancers (including those associated with BRCA1/2 gene mutations). We discuss the issues related to clinical course of multiple primary tumors and their sensitivity to cytostatic and targeted therapy.
Prognostic value of microRNA assessment in cervical epithelial cells of patients with mild dysplasia
Authors: Knyazeva M. S. , Prisyazhnaya Т. S. , Zabegina L. M. , Smirnova О. A. , Mikhetko A. A. , Berlev I. V. , Malek A. V.
Published: March 2021

Background. Currently, there are no reliable markers for the prognosis of the low-grade squamous intraepithelial lesion (LSIL) of the cervical epithelium. Scientific literature provides with inconsistent recommendations regarding the management of the young patients with a cytological diagnosis of LSIL. The progression of cervical dysplasia and the development of cervical cancer are associated with characteristic alterations of the microRNA expression profile.

Objective: to assess the prognostic value of microRNA in LSIL. Materials and methods. Samples (cytological smears) obtained from patients diagnosed with LSIL (n = 36), but with a different course of the disease over the next 6–12 months. Analysis of miRNA expression was carried out by the method of “two-tailed” reverse transcription and subsequent PCR.

Results. The expression level of miR-126, miR-21, miR-1246, miR-182 was statistically significantly different in the compared groups, but the predictive value of the analysis of individual molecules was low (AUC <0.65). Calculation of the concentration ratios of the “reciprocal” pairs of microRNAs made it possible to obtain a more effective prognostic marker. ROC analysis of such ratios (miR-126/miR-182, miR-21/miR-182, miR-1246/miR-182) yielded AUC values: 0.82–0.89, sensitivity: 0.71–0.92; specificity: 0.86.

Conclusions. Analysis of a panel of microRNA marker molecules in the material of the cervical epithelium and calculation of the concentration ratios of “reciprocal” pairs is a promising method for prognosis of LSIL course.