bluuebunny/crossref_metadata_2025 huggingface dataset:
CAR T Cell Therapy’s Potential for Pediatric Brain Tumors
Authors: Thomas Pauline , Galopin Natacha , Bonérandi Emma , Clémenceau Béatrice , Fougeray Sophie , Birklé Stéphane
Published: November 2021

Malignant central nervous system tumors are the leading cause of cancer death in children. Progress in high-throughput molecular techniques has increased the molecular understanding of these tumors, but the outcomes are still poor. Even when efficacious, surgery, radiation, and chemotherapy cause neurologic and neurocognitive morbidity. Adoptive cell therapy with autologous CD19 chimeric antigen receptor T cells (CAR T) has demonstrated remarkable remission rates in patients with relapsed refractory B cell malignancies. Unfortunately, tumor heterogeneity, the identification of appropriate target antigens, and location in a growing brain behind the blood–brain barrier within a specific suppressive immune microenvironment restrict the efficacy of this strategy in pediatric neuro-oncology. In addition, the vulnerability of the brain to unrepairable tissue damage raises important safety concerns. Recent preclinical findings, however, have provided a strong rationale for clinical trials of this approach in patients. Here, we examine the most important challenges associated with the development of CAR T cell immunotherapy and further present the latest preclinical strategies intending to optimize genetically engineered T cells’ efficiency and safety in the field of pediatric neuro-oncology.
The Neglected Liaison: Targeting Cancer Cell Metabolic Reprogramming Modifies the Composition of Non-Malignant Populations of the Tumor Microenvironment
Authors: Iorio Maria , Umesh Ganesh Nikkitha , De Luise Monica , Porcelli Anna Maria , Gasparre Giuseppe , Kurelac Ivana
Published: November 2021

Metabolic reprogramming is a well-known hallmark of cancer, whereby the development of drugs that target cancer cell metabolism is gaining momentum. However, when establishing preclinical studies and clinical trials, it is often neglected that a tumor mass is a complex system in which cancer cells coexist and interact with several types of microenvironment populations, including endothelial cells, fibroblasts and immune cells. We are just starting to understand how such populations are affected by the metabolic changes occurring in a transformed cell and little is known about the impact of metabolism-targeting drugs on the non-malignant tumor components. Here we provide a general overview of the links between cancer cell metabolism and tumor microenvironment (TME), particularly focusing on the emerging literature reporting TME-specific effects of metabolic therapies.
Oncolytic Viruses: Newest Frontier for Cancer Immunotherapy
Authors: Rahman Masmudur M. , McFadden Grant
Published: November 2021

Cancer remains a leading cause of death worldwide. Despite many signs of progress, currently available cancer treatments often do not provide desired outcomes for too many cancers. Therefore, newer and more effective therapeutic approaches are needed. Oncolytic viruses (OVs) have emerged as a novel cancer treatment modality, which selectively targets and kills cancer cells while sparing normal ones. In the past several decades, many different OV candidates have been developed and tested in both laboratory settings as well as in cancer patient clinical trials. Many approaches have been taken to overcome the limitations of OVs, including engineering OVs to selectively activate anti-tumor immune responses. However, newer approaches like the combination of OVs with current immunotherapies to convert “immune-cold” tumors to “immune-hot” will almost certainly improve the potency of OVs. Here, we discuss strategies that are explored to further improve oncolytic virotherapy.
Analysis of NIS Plasma Membrane Interactors Discloses Key Regulation by a SRC/RAC1/PAK1/PIP5K/EZRIN Pathway with Potential Implications for Radioiodine Re-Sensitization Therapy in Thyroid Cancer
Authors: Faria Márcia , Domingues Rita , Bugalho Maria João , Silva Ana Luísa , Matos Paulo
Published: November 2021

The functional expression of the sodium–iodide symporter (NIS) at the membrane of differentiated thyroid cancer (DTC) cells is the cornerstone for the use of radioiodine (RAI) therapy in these malignancies. However, NIS gene expression is frequently downregulated in malignant thyroid tissue, and 30% to 50% of metastatic DTCs become refractory to RAI treatment, which dramatically decreases patient survival. Several strategies have been attempted to increase the NIS mRNA levels in refractory DTC cells, so as to re-sensitize refractory tumors to RAI. However, there are many RAI-refractory DTCs in which the NIS mRNA and protein levels are relatively abundant but only reduced levels of iodide uptake are detected, suggesting a posttranslational failure in the delivery of NIS to the plasma membrane (PM), or an impaired residency at the PM. Because little is known about the molecules and pathways regulating NIS delivery to, and residency at, the PM of thyroid cells, we here employed an intact-cell labeling/immunoprecipitation methodology to selectively purify NIS-containing macromolecular complexes from the PM. Using mass spectrometry, we characterized and compared the composition of NIS PM complexes to that of NIS complexes isolated from whole cell (WC) lysates. Applying gene ontology analysis to the obtained MS data, we found that while both the PM-NIS and WC-NIS datasets had in common a considerable number of proteins involved in vesicle transport and protein trafficking, the NIS PM complexes were particularly enriched in proteins associated with the regulation of the actin cytoskeleton. Through a systematic validation of the detected interactions by co-immunoprecipitation and Western blot, followed by the biochemical and functional characterization of the contribution of each interactor to NIS PM residency and iodide uptake, we were able to identify a pathway by which the PM localization and function of NIS depends on its binding to SRC kinase, which leads to the recruitment and activation of the small GTPase RAC1. RAC1 signals through PAK1 and PIP5K to promote ARP2/3-mediated actin polymerization, and the recruitment and binding of the actin anchoring protein EZRIN to NIS, promoting its residency and function at the PM of normal and TC cells. Besides providing novel insights into the regulation of NIS localization and function at the PM of TC cells, our results open new venues for therapeutic intervention in TC, namely the possibility of modulating abnormal SRC signaling in refractory TC from a proliferative/invasive effect to the re-sensitization of these tumors to RAI therapy by inducing NIS retention at the PM.
The Tumor Dynamism Is the Dark Matter of the NGS Galaxy: How to Understand It?
Authors: Ottaiano Alessandro , Circelli Luisa , Caraglia Michele
Published: November 2021

Since its discovery, there has been a great enthusiasm around NGS (next generation sequencing) technology due to extensive (from restricted gene panels to entire genomes) and rapid (few hours) DNA sequencing [...]
Prognostic Implications of Intratumoral and Peritumoral Infiltrating Lymphocytes in Pancreatic Ductal Adenocarcinoma
Authors: Pyo Jung-Soo , Son Byoung Kwan , Lee Hyo Young , Oh Il Hwan , Chung Kwang Hyun
Published: November 2021

This study aimed to elucidate the prognostic implications of intratumoral and peritumoral infiltrating T-lymphocytes in pancreatic ductal adenocarcinoma (PDAC) through a meta-analysis. A total of 18 eligible studies and 2453 PDAC patients were included in the present study. Intratumoral and peritumoral infiltrating lymphocytes were evaluated using various markers, such as CD3, CD4, CD8, FOXP3, and immune cell score. The correlations between these parameters and overall and disease-free survival were investigated and used in the meta-analysis. High intratumoral infiltration of CD3-, CD4-, and CD8-expressing lymphocytes was significantly correlated with better overall survival (hazard ratio (HR) 0.747, 95% confidence interval (CI) 0.620–0.900, HR 0.755, 95% CI 0.632–0.902, and HR 0.754, 95% CI 0.611–0.930, respectively). However, there was no significant correlation between PDAC prognosis and intratumoral FOXP3 or immune cell score (HR 1.358, 95% CI 1.115–1.655 and HR 0.776, 95% CI 0.566–1.065, respectively). Moreover, there was no significant correlation between the prognosis and peritumoral infiltrating T-lymphocytes. In evaluations of disease-free survival, only high intratumoral CD4 infiltration was correlated with a better prognosis (HR 0.525, 95% CI 0.341–0.810). Our results showed that high intratumoral infiltrating lymphocytes were significantly correlated with a better PDAC prognosis. However, among the tumor-infiltrating lymphocytes, CD3, CD4, and CD8 had prognostic implications, but not FOXP3 and immune cell score.
Natural Disasters—Origins, Impacts, Management
Authors: Chaudhary Muhammad T. , Piracha Awais
Published: November 2021

Natural hazards are processes that serve as triggers for natural disasters. Natural hazards can be classified into six categories. Geophysical or geological hazards relate to movement in solid earth. Their examples include earthquakes and volcanic activity. Hydrological hazards relate to the movement of water and include floods, landslides, and wave action. Meteorological hazards are storms, extreme temperatures, and fog. Climatological hazards are increasingly related to climate change and include droughts and wildfires. Biological hazards are caused by exposure to living organisms and/or their toxic substances. The COVID-19 virus is an example of a biological hazard. Extraterrestrial hazards are caused by asteroids, meteoroids, and comets as they pass near earth or strike earth. In addition to local damage, they can change earth inter planetary conditions that can affect the Earth’s magnetosphere, ionosphere, and thermosphere. This entry presents an overview of origins, impacts, and management of natural disasters. It describes processes that have potential to cause natural disasters. It outlines a brief history of impacts of natural hazards on the human built environment and the common techniques adopted for natural disaster preparedness. It also lays out challenges in dealing with disasters caused by natural hazards and points to new directions in warding off the adverse impact of such disasters.
Toward Computational Accuracy in Realistic Systems to Aid Understanding of Field-Level Water Quality Issues
Authors: Alexander William A.
Published: November 2021

Contemplating what will unfold in this new decade and those after, it is not difficult to imagine the increasing importance of conservation and protection of clean water supplies. A worrying but predictable offshoot of humanity’s technological advances is the seemingly ever-increasing chemical load burdening our waterways. In this perspective are presented a few modest areas where computational chemistry modelling could provide benefit to these efforts by harnessing the continually improving computational power available to the field. In the acute event of a chemical spill incident, true quantum-chemistry-based predictions of physicochemical properties and surface-binding behaviors can be used to help decision making in remediating the spill threat. The chronic burdens of microplastics and perfluorinated “forever chemicals” can also be addressed with computational modelling to fill the gap between feasible laboratory experiment timescales and the much-longer material lifetimes. For all of these systems, field-level accuracy models will avail themselves as the model computational systems are able to incorporate more realistic features that are relevant to water quality issues.
Influence of a complex feed additive on the morphological and biochemical parameters of the blood of first-calf heifers during the period of increasing the milk yield
Authors: Sabitov M. T. , Farkhutdinova A. R. , Malikova M. G. , Karmatskikh Yu. A.
Published: November 2021

It is known that mineral additives play an important role in increasing the productivity and efficiency of the animal husbanry industry as a whole. The state of the body can be assessed by the content of mineral substances in a blood test. The purpose of the work was to study changes in morphological and biochemical blood parameters in first-calf heifers during the period of increasing the milk yield when they are fed a complex mineral and vitamin feed additive (CMVFA). The study of the influence of feeding the complex mineral and vitamin feed additive in the ration to first-calf heifers during the the period of increasing the milk yield on morphological and biochemical blood parameters has been carried out. The experiments were carried out in 2019–2020 in the OOO Breeding Farm “Valiev” in the Dyurtyulinsky district in the Republic of Bashkortostan on 3 groups of first-calf heifers of Black-and-White breed per 15 heads in each selected by the method of pairs of analogues. The animals of the control group received the main ration (MR) adopted on the farm, the 1st experimental group MR+120 g/head CMVFA according to the recipe No. 1, the 2nd experimental group MR+120 g/head CMVFA according to the recipe No. 2. In the ration of animals of the control group there was a deficiency of basic macro- and microelements. The use of CMVFA as part of the ration of first-calf heifers during the period of increasing the milk yield had a positive effect on the morphological and biochemical parameters of blood. Studies have shown that the use of CMVFA in the rations of first-calf heifers provided the need for minerals and vitamins, accelerating metabolic processes in the body during the most stressful period of lactation, the period of increasing the milk yield. According to the results of biochemical blood parameters, it is possible to esimate the improvement of protein, carbohydrate and mineral and vitamin nutrition in the first-cakf heifers of the experimental groups during the period of increasing the milk yield, which showed their genetic potential more fully and used nutrients more effectively for milk synthesis.
Rearing of rainbow trout in cages on warm waters with using the feed additive Sangrovit Extra
Authors: Vlasov V. A. , Elshov A. V.
Published: November 2021

Increasing the efficiency of feed with the use of different feed additives is becoming a particularly common method in aquaculture. Sangrovit Extra is a plant feed additive for increasing the productivity of farm animals due to the anti-infl ammatory and immunomodulatory properties of its components. The purpose of the research was to evaluate the effectiveness of the use of the Sangrovit Extra additive as part of trout compound feed in feeding rainbow trout when rearing in cages on the warm waters of the regional hydroelectric power plant. The object of research was individuals of rainbow trout. The introduction of the Sangrovit Extra feed additive in the amount of 400 mg/kg into the main diet of fish best contributed to the increase in the average daily gain of trout in cages by 0,48 g compared to the control group. The use of the studied additive contributed to the increase in the assimilation of feed, which was manifested in the indicator of its consumtion. When trout weighing 200–300 g were grown on the main diet (without additives), feed consumption per 1 kg of fish growth amounted to 1,26 kg, whereas when introduced into the feed in the amount of 100 mg/kg, 400 and 700 mg/kg, the efficiency of feed use increased by 9 %, 11 and 5 %, respectively. When rearing larger trout (1,2–1,5 kg), feed consumptions when using the additive in the amount of 400 mg/kg decreased from 1,47 to 1,36 kg, i.e. by 10,8 %. The use of the Sangrovit Extra additive when rearing commercial rainbow trout in cages on warm waters has shown the economic feasibility of its use, especially at the dosage of 400 mg/kg of feed. The level of profitability for rearing trout weighing 0,3 kg was 18,6 % higher, and for fish weighing 0,5 kg by 12,7 % compared to the control group.
Deli Dumrul Anti-kahraman Olabilir mİ?
Authors: KUZAY DEMİR Gonca
Published: November 2021

Dede Korkut Kitabı’ndaki anlatmalar üzerine günümüze kadar oldukça önemli çalışmalar yapılmıştır. Bu çalışmaların büyük bir çoğunluğu anlatmaların yapısal analizi üzerine kurgulanmış; anlatmalarda vurgulanan toplumsal birlik ve bütünlüğün sağlanışı farklı kahramanların maceraları ile çözümlenmiştir. Çalışmaların bir kısmı ise özellikle Dede Korkut anlatmalarındaki kahraman tiplerine yoğunlaşmıştır. Dede Korkut’un yiğitlerinin korkusuz, adaletli, cesur, akıllı ve zeki gibi bir dizi olumlu sıfatla anılan Türk destanlarında karşılaştığımız alp tipi kahraman tipolojisine uyum sağladığı tespit edilmiştir. Günümüze kadar elde edilen on üç anlatma içinde yalnızca Duha Koca Oğlu Deli Dumrul anlatmasında kahraman tipinin farklılık gösterdiği ortaya konulmuştur. Bireysel bir olayın ele alındığı anlatmanın, farklılık arz eden içerik ve yapı özellikleri üzerinde durulmuştur. Bu makalede; Deli Dumrul’un kahraman tipolojisi çözümlenmeye çalışılmıştır. Çalışmada öncelikle Dede Korkut anlatmalarındaki alp tipinin özellikleri verilmiş, daha sonra Duha Koca Oğlu Deli Dumrul anlatmasını farklı kılan özellikler belirlenmiş, Deli Dumrul’un geleneksel kahraman tipolojisinden ayrılan yönleri tartışılarak Deli Dumrul’un anti-kahraman olarak kabul edilip edilemeyeceği tartışılmıştır. Çalışmanın sonunda kahraman tipoloji çözümlemesi bakımından; Deli Dumrul’un Dede Korkut anlatmaları içerisindeki varlığı işlevsel olarak çözümlenmeye çalışılmıştır.
Neighboring Atom Collisions in Solid-State High Harmonic Generation
Authors: Zuo Ruixin , Trautmann Alexander , Wang Guifang , Hannes Wolf-Rüdiger , Yang Shidong , Song Xiaohong , Meier Torsten , Ciappina Marcelo , Duc Huynh Thanh , Yang Weifeng
Published: November 2021

High harmonic generation (HHG) from solids shows great application prospects in compact short-wavelength light sources and as a tool for imaging the dynamics in crystals with subnanometer spatial and attosecond temporal resolution. However, the underlying collision dynamics behind solid HHG is still intensively debated and no direct mapping relationship between the collision dynamics with band structure has been built. Here, we show that the electron and its associated hole can be elastically scattered by neighboring atoms when their wavelength approaches the atomic size. We reveal that the elastic scattering of electron/hole from neighboring atoms can dramatically influence the electron recombination with its left-behind hole, which turns out to be the fundamental reason for the anisotropic interband HHG observed recently in bulk crystals. Our findings link the electron/hole backward scattering with Van Hove singularities and forward scattering with critical lines in the band structure and thus build a clear mapping between the band structure and the harmonic spectrum. Our work provides a unifying picture for several seemingly unrelated experimental observations and theoretical predictions, including the anisotropic harmonic emission in MgO, the atomic-like recollision mechanism of solid HHG, and the delocalization of HHG in ZnO. This strongly improved understanding will pave the way for controlling the solid-state HHG and visualizing the structure-dependent electron dynamics in solids.
SYNTHESIS OF CARBON DOTS (CDS) AND DETERMINATION OF OPTICAL GAP ENERGY WITH TAUC PLOT METHOD
Authors: Jumardin Jumardin , Maddu Akhiruddin , Santoso Koekoeh , Isnaeni Isnaeni
Published: November 2021

Carbon Dots (CDs) which have been synthesized using the laser ablation method show the presence of UV-Vis absorption in the wavelength range of 303 nm to 333 nm for absorbance and 495 nm to 503 nm for fluorescence. Changes in the time duration 1, 2, 3 hours of CDs resulted in changes in the optical energy gap. The optical energy gap valuesare distinguished by the type of indirect transition (n=2) is 3.40 eV (1 hour), 3.15 eV (2 hour), 2.85 eV (3 hour) and direct transition (n=1/2) is 2.58 eV (1 hour), 2.31 eV (2 hour), 1.70 eV (1 hour).
PURIFICATION OF DUG WELL WATER USING ACTIVATED CARBON MADE FROM SAGO FIBER WASTE
Authors: Desprianto Desprianto , Supu Idawati , Suliawati Ika , Juwita Juwita , Erfiana Erfiana
Published: November 2021

The sago fiber waste is promising as an active carbon material which has a high adsorption in purifying water process. The objective of this research was to make activated carbon from sago fiber waste to be applied for water purification and iron (Fe) adsorption with various of contact time. The carbon activation process uses Phosphoric Acid (H3PO4) and calcined at 800 °C for 2 hours. After drying, then analyzed the water content and ash content. Furthermore, surface morphology testing was carried out using SEM. The application of activated carbon was carried out in dig well water purification and filtering iron (Fe) based on variations in contact time of 10 minutes, 20 minutes, 30 minutes and 40 minutes. Analysis of water content of activated carbon was carried out 3 times with an average value of 3.9662%. Ash content analysis aims to determine the metal oxide content in activated carbon. Analysis of the ash content of activated carbon was carried out 3 times with an average value of 5.3239%. The average value of ash content meets the quality standards of activated carbon SNI 06-3730-1995 where the standard value of ash content for powdered activated carbon is a maximum of 10%. SEM test results show that the surface of the activated carbon is porous but the size is not uniform. The level of Ferrium (Fe) in water that has gone through the purification process using activated carbon. The most effective contact time was obtained, namely 20 minutes and had met the threshold requirements for water turbidity levels according to Minister of Indonesia health. This means that activated carbon from sago fiber is able to adsorb the material contained in water and also very capable in  picking up some bad contents of cloudy and polluted water.
Escuelas y aulas inclusivas. Apostando por proyectos educativos compartidos
Authors: Darretxe Urrutxi Leire , Álvarez-Rementería Álvarez María , Ozerinjauregi Beldarrain Nagore
Published: November 2021

En este artículo, de carácter teórico, se presentan las características fundamentales que facilitan el desarrollo de escuelas y aulas inclusivas a tener en cuenta para cualquier profesional educativo. Para ello, a partir de la literatura disponible fundamentalmente en el contexto europeo, se presenta una descripción de los aspectos más destacados de un proyecto educativo compartido, destacando la participación de la comunidad educativa, la reorganización de los espacios, los servicios educativos y el currículum y los valores éticos que deben orientar este camino hacia la inclusión. Tras ello, se recogen ejemplos destacados de proyectos y prácticas educativas que favorecen el desarrollo de espacios más inclusivos. El proyecto de Comunidades de Aprendizaje es una propuesta de trasformación educativa que, en el marco del aprendizaje dialógico, impulsa actuaciones educativas de éxito como son los grupos interactivos, la extensión del tiempo de aprendizaje, las tertulias dialógicas y la participación de las familias y otros miembros de la comunidad, entre otras.
Jóvenes, escuela técnica y trabajo Experiencias de escolarización en contextos de pobreza urbana (Rosario, Santa Fe)
Authors: Debonis Florencia , López Fittipaldi Marilín , Saccone Mercedes
Published: November 2021

En este escrito recuperamos el trabajo realizado en dos proyectos de investigación colectivos, ambos inscritos en una línea de investigación centrada en procesos socioeducativos en contextos de pobreza y distintas violencias en la ciudad de Rosario (Santa Fe, Argentina) y orientados desde un enfoque socio-antropológico (Achilli, 2005).

Analizamos la relación entre escuela técnica y trabajo en las experiencias de jóvenes que viven en contextos de pobreza urbana: los sentidos sobre la escolarización y su vinculación con el trabajo desde la perspectiva de los y las jóvenes; los sentidos sobre la modalidad técnico profesional; el sostenimiento de la escolaridad en articulación con sus condiciones de vida.

Sostenemos que los/as jóvenes llegan a esta escuela por diversos motivos, no necesariamente vinculados a la elección de la modalidad técnico profesional en administración y gestión, no obstante, el conocimiento y la valoración sobre la misma se va construyendo a lo largo de la experiencia escolar con sentidos heterogéneos. Estos sentidos están atravesados fuertemente por el vínculo que se establece entre la educación y el trabajo en términos de posibilitar el acceso a mejores condiciones de vida.
El Valle de los Caídos: la ruina y sus evocaciones
Authors: Tebar Hurtado Javier
Published: November 2021

Nuestro propósito es reflexionar sobre el concepto de ruina y las evocaciones que suscita a partir de un espacio memorial como es el Valle de los Caídos, situado a pocos kilómetros de Madrid (España), que generó el pasado año 2019 una fuerte controversia política y social en el país. A partir de cuatro aproximaciones diferenciadas, pero que tienen su nexo de unión en el propio monumento heredado de la dictadura franquista, nos interrogamos sobre la relación entre memoria y espacialidad, así como sobre la configuración de un monumento de exaltación de la victoria de la guerra civil cuyas significaciones en el marco del actual sistema democrático son múltiples y contrapuestas, imposibilitando hacer de él un espacio de reconciliación entre los españoles.
Juridical Review Consumer Legal Against Labeling Of Food Products Based On Law No. 8 Year 1999
Authors: Ritonga Martina Lestari
Published: November 2021

Consumer protection is in line with the development of the world economy. The rapid development of the world economy, especially in the trade sector, produces various types and variations of each type of goods and/or services that can be consumed. For consumers, information about goods and/or services is a basic need, before they use sources of funds to conduct consumer transactions with these goods and/or services. The right to correct information is one of the rights of consumers as regulated in Article 4 of Law no. 8 of 1999 concerning Consumer Protection. One source of the correct information is the label. In article 1 paragraph (3) of PP no. 69 of 1999 concerning Food Labels and Advertisements defines that what is meant by Food Labels is "any information regarding food in the form of pictures, writing, a combination of both or other forms that are attached to food, inserted into, affixed to or part of food packaging". From the definition of the label, it is known that the label contains information about the food produced. However, the problem of labeling, especially regarding food labels, has received less attention from consumers and business actors. Information that is not true and misleads consumers results in losses to consumers which ultimately results in legal consequences for business actors in taking responsibility for them. The type of research used in this research is normative legal research, which is a study that places norms as the object of research in this case is Law no. 8 of 1999. The type of approach used in this research is descriptive analytical approach, namely research based on one or two interrelated variables based on general theories/concepts that are applied to explain a set of data or show comparisons or relationships. Data collection is done by researching library materials (Library Research). Legal data analysis in this paper uses qualitative data. From the results of this research, it can be concluded that the provisions for labeling food products meet the principles of consumer protection and violations of food product labeling by business actors can be subject to civil, criminal and administrative responsibility.
Implementasi Kurikulum 2013 di Madrasah Ibtidaiyah KAHASRI Kota Probolinggo Tahun Pelajaran 2018/2019
Authors: Rohma Allifatur
Published: November 2021

Madrasah Ibtidaiyah KAHASRI merupakan lembaga yang ditunjuk oleh Kementerian Agama RI untuk melaksanakan Kurikulum 2013 atau yang disebut K13 baik pada pembelajaran tematik maupun pembelajaran agama sesuai dengan Keputusan Direktur Jendral Pendidikan Islam Nomor 3525 tahun 2017 tentang Penetapan Pelaksanaan Kurikulum 2013. Berdasarkan latar belakang tersebut, maka fokus penelitian adalah: 1) Bagaimana perencanaan pembelajaran kurikulum 2013 di Madrasah Ibtidaiyah KAHASRI Kota Probolinggo Tahun Pelajaran 2018/2019? 2) Bagaimana pelaksanaan pembelajaran kurikulum 2013 di Madrasah Ibtidaiyah KAHASRI Kota Probolinggo Tahun Pelajaran 2018/2019?, 3) Bagaimana evaluasi pembelajaran  kurikulum 2013 di Madrasah Ibtidaiyah KAHASRI Kota Probolinggo Tahun Pelajaran 2018/2019? Hasil penelitiannya adalah: 1) Perencanaan pembelajaran K13, guru di Madrasah Ibtidaiyah KAHASRI Kota Probolinggo membuat perangkat pembelajaran berupa Kalender Pendidikan, RPE, Prota, Promes, Silabus, dan RPP. Dalam pembuatan perangkat pembelajaran ada guru yang membuat perangkat pembelajaran secara individu dan ada yang dengan bersama KKG (Kelompok Kerja Guru). (2) Pelaksanaan pembelajaran K13 di Madrasah Ibtidaiyah KAHASRI Kota Probolinggo memiliki 3 kegiatan yaitu, kegiatan pendahuluan, inti, dan penutup. Pada kegiatan pendahuluan diawali dengan memberikan apersepsi, memberikan stimulus/motivasi, menyampaikan tujuan dan manfaat pembelajaran. Pada kegiatan inti guru telah melakukan kegiatan saintifik yang meliputi kegiatan mengamati, menanya, mencoba, mengasosiasi/mengumpulkan, dan mengkomunikasikan. Pada kegiatan penutup dilakukan dengan membuat kesimpulan dari materi yang telah dipelajari, merefleksikan materi yang diajarkan, dan memberikan tindak lanjut berupa penugasan. (3) Evaluasi pembelajaran K13 di Madrasah Ibtidaiyah KAHASRI Kota Probolinggo menggunakan model penilaian autentik yang meliputi 3 aspek yaitu: aspek sikap, aspek pengetahuan, dan aspek keterampilan.
Kompetensi Pedagogik Guru dalam Melaksanakan Pembelajaran Tematik Di Madrasah Ibtidaiyah Miftahul Hidayah Tegalsari Banyuwangi
Authors: Ummah Ulfi Khoirotul , Munir Akhmad
Published: November 2021

Kompetensi pedagogik merupakan kemampuan yang harus dimiliki guru dalam mengelola pembelajaran. Berkaitan dengan pengelolaan Pembelajaran Tematik fakta di sekolah menunjukkan banyak guru belum sepenuhnya mampu mengimplementasikan pembelajaran yang memiliki prinsip mengintegrasikan banyak materi. Untuk itu, penelitian ini bertujuan untuk mendeskripsikan kemampuan guru: 1) Memahami peserta didik dalam melaksanakan Pembelajaran Tematik di MI Miftahul Hidayah Tegalsari Tahun Pelajaran 2018/2019. 2) Merencanakan pembelajaran dalam melaksanakan Pembelajaran Tematik di MI Miftahul Hidayah Tegalsari Tahun Pelajaran 2018/2019. 3) Melaksanakan pembelajaran pada Pembelajaran Tematik di MI Miftahul Hidayah Tegalsari Tahun Pelajaran 2018/2019. 4) Mengevaluasi hasil belajar dalam melaksanakan Pembelajaran Tematik di MI Miftahul Hidayah Tegalsari Tahun Pelajaran 2018/2019. Hasil penelitian menunjukkan bahwa: 1) Kemampuan guru memahami peserta didik sudah sesuai indikator kompetensi pedagogik. 2) Kemampuan guru merencanakan pembelajaran sudah sesuai dengan indikator kompetensi pedagogik. 3) Kemampuan guru dalam melaksanakan pembelajaran ada satu indikator yang perlu diperbaiki. 4) Kemampuan dalam mengevaluasi hasil belajar sudah sesuai dengan indikator kompetensi pedagogik.
Etnomatematika Pada Candi Selogending Di Desa Kandangan Sebagai Sumber Belajar Matematika Kelas IV Sekolah Dasar
Authors: Ainurriza Riski , Sugiarti Titik , Hutama Fajar Surya
Published: November 2021

Innovations to enrich mathematics learning resources can be expressed in the form of culture-based or ethnomatematic learning. The purpose of this study was to analyze the ethnomatematic content of Selogending Temple in Kandangan as mathematics teaching material for grade 4 elementary school students. This type of research uses qualitative research. Sources of research data are Selogending Temple and resource persons related to the Selogending Temple site. This study uses data collection methods in the form of observation, interviews, and documentation. Qualitative data analysis techniques used are reduction and data exposure, and drawing conclusions. Based on the results of the study, it can be concluded that there are mathematical elements in Selogending Temple including plane geometry, spatial geometry and reflection. The Selogending Temple building which has ethnomatic content is the Entrance Gate, Mbah Tejo Kusumo Petilasan, Mbah Pukulun Petilasan, Patrapan Hall, shrine, Padma, Wadung Prabu, Linggasiwa, and Mbah Raden Selogending Petilasan.
Inovasi untuk memperkaya sumber belajar matematika dapat dituangkan dalam bentuk pembelajaran berbasis kebudayaan atau etnomatematika. Tujuan penelitian ini adalah menganalisis muatan etnomatematika pada Candi Selogending di Kandangan, Kabupaten Lumajang, Provinsi Jawa Timur sebagai bahan ajar matematika kelas 4 SD. Jenis penelitian ini menggunakan penelitian kualitatif. Sumber data penelitian adalah Candi Selogending dan narasumber terkait situs Candi Selogending. Penelitian ini menggunakan metode pengumpulan data berupa observasi, wawancara, dan dokumentasi. Teknik analisis data kualitatif yang digunakan yaitu reduksi dan pemaparan data, serta penarikan kesimpulan. Berdasarkan hasil penelitian dapat disimpulkan bahwa terdapat unsur matematika pada Candi Selogending meliputi bangun geometri bidang, geometri ruang dan pencerminan. Bangunan Candi Selogending memiliki yang memiliki muatan etnomatematika adalah Gapura Pintu Masuk, Petilasan Mbah Tejo Kusumo, Petilasan Mbah Pukulun, Balai Patrapan, tempat pemujaan, Padma, Wadung Prabu, Linggasiwa, dan Petilasan Mbah Raden Selogending.
Pengembangan Program Pembelajaran Pendidikan Agama Islam dalam Meningkatkan Budaya Keagamaan di SDN Bletok Bungatan Situbondo
Authors: Azizi Muhammad
Published: November 2021

Pengembangan budaya keagamaan di sekolah merupakan suatu kewajiban yang harus dilaksanakan oleh sekolah dengan mendesain program pendidikan agama islam yang mengarah pada pengembangan budaya keagamaan. Fokus penelitian ini adalah Bagaimana perencanaan pengembangan program pembelajaran Pendidikan Agama Islam dalam meningkatkan budaya keagamaan di SDN Bletok Bungatan Situbondo? Bagaimana pelaksanaan pengembangan program pembelajaran Pendidikan Agama Islam dalam meningkatkan budaya keagamaan di SDN Bletok Bungatan Situbondo? dan Bagaimana pengawasan pengembangan program pembelajaran Pendidikan Agama Islam dalam meningkatkan budaya keagamaan di SDN Bletok Bungatan Situbondo? Penelitian ini menggunakan pendekatan deskriptif analisis, jenis studi kasus. Teknik pengumpulan data menggunakan wawancara, observasi, dan dokumentasi. Analisis data menggunakan model interaktif dan keabsahan data menggunakan triangulasi sumber. Hasil dari penelitian ini menunjukkan: 1) Perencanaan pengembangan program pembelajaran pendidikan agama islam dalam meningkatkan budaya keagamaan di SDN Bletok Bungatan Situbondo, yaitu: penyusunan buku pintar, Penugasan anggota membuat rancangan kegiatan, nilai-nilai karakter prioritas utama, rencana strategis pendekatan botton up, perencanaan pengembangan budaya keagamaan oleh tim agama. 2) Pelaksanaan pengembangan program pembelajaran pendidikan agama islam dalam meningkatkan budaya keagamaan di SDN Bletok Bungatan Situbondo, yaitu: Roling tanggung jawab job deskription pengembangan budaya, Quality Insurence (Jaminan Mutu) pembiasaan keagamaan, Model uswah guru, pelaksanaan Budaya keagamaan. 3) Pengawasan pengembangan program pembelajaran pendidikan agama islam dalam meningkatkan budaya keagamaan di SDN Bletok Bungatan Situbondo, yaitu: pengawasan internal kinerja anggota dan eksternal melalui pengguna layanan siswa dan orang tua, evaluasi supervisor sekolah terhadap kinerja anggota, anak berkepribadian sesuai dengan nilai-nilai agama, monitoring oleh komponen sekolah dan tim agama, monitoring siswa, monitoring tingkah laku dan pembiasaan siswa, penetapan capaian dari Quality Insurence.
Penanaman Nilai-Nilai Pendidikan Agama Islam Pada Masa Pandemi Covid-19 Di Madrasah Ibtidaiyah
Authors: Laili Faiqotul , Barata Paga Tri
Published: November 2021

The inculcation of Islamic religious values ??is an effort to shape the character of students to achieve a degree as a human being who is in accordance with norms, culture and religion. This research describes the process of internalization and the method of cultivating Islamic religious values ??in an unusual situation, namely in the era of the Covid-19 pandemic. In this study, researchers used a qualitative approach, a type of case study with interview and observation data collection techniques. The results of this study indicate that the implementation of student learning in a pandemic situation is carried out in two ways, namely (1) online and (2) offline. The values ??instilled in students include (a) worship, (b) faith and (c) morals. Meanwhile, the methods used by teachers in the process of inculcating Islamic religious values ??during the pandemic were practice methods, guidance methods, and memorization methods.
Keywords: Education, Islamic Religious Values, Covid-19
Penanaman nilai-nilai agama Islam merupakan sebuah upaya dalam membentuk karakter siswa untuk mencapai derajat sebagai manusia yang sesuai norma, budaya serta agama. penelitian ini mendeskripsikan proses internalisasi hingga metode penanaman nilai-nilai agama Islam di situasi yang tidak biasa yakni di era pandemi covid-19. Dalam penelitian ini, peneliti menggunakan pendekatan kualitatif, jenis studi kasus dengan teknik pengumpulan data wawancara dan observasi. Hasil dari penelitian ini menunjukkan bahwa pelaksanaan pembelajaran siswa dalam situasi pandemi dilakukan dengan dua cara yakni (1) daring dan (2) luring. Nilai-nilai yang ditanamkan kepada siswa meliputi (a) ibadah, (b) keimanan dan (c) akhlak. Sedangkan metode-metode yang digunakan guru dalam proses penanaman nilai-nilai agama Islam selama pandemi adalah metode praktik, metode bimbingan, dan metode hafalan.
Kata Kunci: Pendidikan, Nilai-nilai Agama Islam, Covid-19
Implementasi Strategi Student Team Achievement Divisions Dalam Pembelajaran Tematik Terpadu Di SD Darus Sholah Jember
Authors: Nasilah Nasilah , Winarno Ahmad
Published: November 2021

This research was conducted at SD Darus Sholah, Jember which aims to answer the main problems related to the implementation of the Student Team Achievement Divisions learning strategy in integrated thematic learning. The problem studied in this research is the Implementation of the Student Team Achievement Divisions Strategy in integrated thematic learning at SD Darus Sholah, Jember. This research approach uses a qualitative approach with the type of phenomenological research. Methods of data collection using interviews, observation and documentation. Data analysis used the interactive model of Miles and Huberman, with the process of data collection, condensation, data display, and data verification. To test the validity of the data using triangulation. The results of this study indicate that: 1) At the presentation stage, the teacher starts with story material, reviews previous material, and learning activities in teams. 2) The teacher prepares a worksheet as a guide for group work and each member can contribute, the teacher makes observations, provides guidance, motivation, and assistance if needed. 3) Individual tests in groups. 4) Score development for individuals, the teacher combines the previous score with the final score. 5) Appreciation for the team is based on the assessment of individuals in the group so that the process of group assessment recapitulation is based on individual assessment of each group.
Keywords: STAD Model; Learning, Thematic; Primary school
Penelitian ini dilakukan di SD Darus Sholah Jember yang bertujuan untuk menjawab pokok permasalahan berkaitan dengan penerapan strategi belajar Student Team Achievement Divisions dalam pembelajaran tematik terpadu. Permasalahan yang dikaji dalam penelitian ini, Implementasi Strategi Student Team Achievement Divisions dalam pembelajaran tematik terpadu di SD Darus Sholah Jember. Pendekatan penelitian ini menggunakan pendekatan kualitatif dengan jenis penelitian fenomenologis. Metode pengumpulan data menggunakan wawancara, observasi dan dokumentasi. Analisis data menggunakan model analisis interaktif Miles dan Huberman, dengan proses data collection, condensation, data display, and data verifiying. Untuk menguji keabsahan data menggunakan trianggulasi. Hasil penelitian ini menunjukkan bahwa: 1) Pada tahap presentasi, guru memulai dengan materi cerita, mereview ulang materi sebelumnya, dan kegiatan belajar dalam tim. 2) Guru menyiapkan lembaran kerja sebagai pedoman kerja kelompok dan setiap anggota dapat berkontribusi, guru melakukan pengamatan, memberikan bimbingan, motivasi, dan bantuan jika diperlukan. 3) Tes individu dalam kelompok. 4) Skor pengembangan bagi individu, guru menggabungkan skor nilai sebelumnya dengan skor akhir. 5) Penghargaan bagi tim mendasarkan kepada penilaian terhadap individu dalam kelompok sehingga proses rekapitulasi penilaian kelompok, didasarkan kepada penilain individu masing-masing kelompok.
Kata Kunci: Model STAD; Pembelajaran, Tematik; Sekolah Dasar
High-spatial-resolution measurement of magnetization distribution using polarized neutron imaging
Authors: Sasada S. , Hiroi K. , Osanai K. , Shinohara T. , Watanabe K. , Uritani A.
Published: November 2021

The evaluation of the magnetization distribution inside a bulk magnet is important for ensuring the performance of automotive motors because it strongly depends on the quality of magnetization inside the permanent magnet. In the conventional destructive method, it is difficult to accurately measure the magnetization with a high spatial resolution. The polarized neutron imaging technique can be used to visualize the distribution of the magnetic flux density inside a magnet nondestructively. In this study, we demonstrated the imaging of the magnetization distribution using polarized neutrons in an anisotropic ferrite magnet sample. The 2D distribution of the magnetization was experimentally obtained by polarized neutron imaging with a high spatial resolution of less than 1 mm. Furthermore, the validity of the results was confirmed by comparing them with those obtained using the conventional destructive method.
Miniaturization process of three-dimensional nanostructures fabricated by focused-ion-beam chemical vapor deposition
Authors: Kometani Reo , Katsuda Moe
Published: November 2021

A miniaturization process for three-dimensional (3D) nanostructures fabricated by focused-ion-beam chemical vapor deposition was proposed in this study. Carbon nanostructures with a Ga–C core and C shell were miniaturized by controlling the diameter of the Ga–C core using annealing and removing the C shell using reactive ion etching. The process characteristics were also evaluated. Furthermore, we demonstrated the miniaturization of the 3D structures. As a result, the diameters of carbon nanopillars in an array were miniaturized from approximately 71 nm to approximately 17 nm. In addition, the proposed miniaturization process was useful to sharpen the edges of nanostructures.
Top-gate transistors fabricated on epitaxially grown molybdenum disulfide and graphene hetero-structures
Authors: Tsai Po-Cheng , Huang Hon-Chin , Chiang Chen-Tu , Wu Chao-Hsin , Lin Shih-Yen
Published: November 2021

We have demonstrated that by using the thermal evaporator, wafer-scale and uniform bi-layer MoS2 can be grown on graphene surfaces without introducing significant damage to the graphene channel. Compared with the top-gate transistors fabricated on standalone graphene films, the field-effect mobility value enhancement from 9.3 to 35.0 cm2 V−1·s−1 is observed for the device fabricated on the MoS2/graphene hetero-structures, which suggests that the MoS2 layer can act as an efficient passivation layer to the graphene channel. Similar field-effect mobility values obtained for the device with only a mono-layer MoS2 passivation layer are also demonstrated.
CONSTRUCTION OF SPECIES-SPECIFIC PRIMERS FOR MOLECULAR-GENETIC IDENTIFICATION OF PORCINE TESCHOVIRUSES AND ETEROVIRUSES A AND B
Authors: Golovko A.M. , Derevyanko S.V. , Bova T.O. , Soroka V.I. , Katsymon V.V.
Published: November 2021

The species-specific primers for identification of taxonomic positions of strains of Porcine Teschovirus, Porcine Enterovirus A and Porcine Enterovirus B kinds were developed. The reclassification of 10 strains of Porcine Enterovirus isolated in Ukraine was performed. In conformity to the international classification they were referred to the Тeschovirus genus of Porcine Teschovirus specie. Performed investigations had created a basis for elaboration of domestic moleculargenetic diagnostic test systems
REGIONAL PECULIARITIES OF CHERRY LEAF ROLL NEPOVIRUS PREVALENCE IN SOUR AND SWEET CHERRY ORCHARDS
Authors: Tryapitsyna N.V. , Vasyuta S.O.
Published: November 2021

The irregularity of regional distribution of Cherry leaf roll virus in sour and sweet cherry fruit orchards in five regions of Ukraine was investigated. Certain regional phytovirological risks were estimated. The possible ways of virus transmission were analyzed.
EFFECT OF PSEUDOMONAS PUTIDA 17 ON THE ACCUMULATION OF PHYTOHORMONES IN VERMICOMPOST
Authors: Gatsenko M.V. , Volkogon N.V. , Lutsenko N.V. , Volkogon V.V.
Published: November 2021

The ability of Pseudomonas putida 17 bacteria to produce physiological active compounds was studied. The data provided confirms the biosynthesis of auxin and cytokinin phytohormones by this bacterium. The introduction of P. putida 17 in composted substrate enriched with phosphorites in the beginning of composting provides accumulation of phytohormones in the compost.
INFLUENCE OF MODERN HERBICIDES ON FORMATION SOYBEAN-RHIZOBIAL SYMBIOSIS AT USE OF MICROBIC PREPARATION RHIZOGUMIN
Authors: Pyschur I.M. , Kanivets V.I. , Larchenko I.V.
Published: November 2021

It was established that soil herbicides Gezagard 500 FW, Primekstra TZ Gold 500 SC, Pirate, Selamid in field conditions inhibit formation of soybean-rhizobial symbiosis and have a phytotoxic action on plants. In order to reduce the negative influence of herbicides on the symbiosis formation at application of Rhizogumin at soybean crops it is recommended to use some of the herbicides ahead of time, for example, Selamid, operating substance – acetochlor (substance group – chloroacetamide) which quickly decays.
THE PARTICULARITIES OF THE DEVELOPMENT OF LUPINE YELLOW INFECTED WITH BEAN YELLOW MOSAIC VIRUS
Authors: Pirog A.V , Dmitruk O.A. , Mamchur A.E. , Kolomiets L.P.
Published: November 2021

The paper outlines the results of experiments with the lupine yellow of Progressive cultivar. It was established that its infection with bean yellow mosaic virus reduces the indices of plants growth and development (decrease of plant mass on 14,0-30,4 %, root mass – on 8-24 % in different phases of ontogenesis, area of leave surface – on 10 %). The viral infection prevents the realization of the photosynthesis and symbiotic nitrogen fixation potentials (the reduction of chlorophyll a contents in leaf on 5,2 %, chlorophyll b – on 6,5 %, nodule masses – on 13-32 %, nitrogenase activity – on 9,1 %). That reduces green mass (on 15 %) and grain productivity (the amount formed bob in phase of the blossom was decreased on 27,5 %).
PRODUCTIVITY AND GRAIN QUALITY OF SOYBEAN DEPENDING ON TILLAGE, FERTILIZERS AND BIOLOGICAL PREPARATIONS APPLICATION IN NORTHERN STEPPE OF UKRAINE
Authors: Grigorieva O. M.
Published: November 2021

The paper presents the results of microbial preparation Rhizohumin effects both individually and in combination with the plant growth regulators Biolan and Biosil on productivity of soybeans of Medeya variety under different fertilization background and soil tillage. Higher level of productivity and high economic efficiency indices were obtained on the natural background with plowing and seeds inoculation with Rhizohumin and Biolan with subsequent crops treatment with Biosil.