bluuebunny/crossref_metadata_2025 huggingface dataset:
Facing posttraumatic stress disorder in Brazil: a survey of therapist practices
Authors:   Fleximind Psicologia, Brazil, Carrijo Cameoka Michelli , Jobim Santi Luísa ,   Federal University of Minas Gerais, Brazil, Singer Vermes Joana ,   Paradigma Center for Behavioral Sciences, Brazil, Lopes Rodrigues Carlos Manoel ,   Brasília University Center, Brazil
Published: June 2024

This study examines the treatment of PTSD in Brazil, a diverse country with limited research on the topic. It surveyed 208 psychologists and physicians who had treated PTSD cases, focusing on their approaches. The study found that 48.1% used screening instruments, with Cognitive Behavioral Therapy (CBT) being the most commonly adopted theoretical model (49%). Over 20 different theoretical affiliations were mentioned, and 41.3% of clinicians adhered to multiple theories. Criteria like individual case analysis, scientific evidence, and treatment acceptance guided treatment selection. Surprisingly, widely accepted trauma-focused therapies were not extensively used. Lack of PTSD education in undergraduate programs (38.5%) was identified as a significant barrier. These findings can inform mental health policies and highlight the need for evidence-based therapy training in educational institutions.
A INFLUÊNCIA MIDIÁTICA NO TRIBUNAL DO JÚRI
Authors: Rodrigues Adriana Alves , Disconzi Verônica Silva do Prado
Published: June 2024

O presente estudo trata da influência exercida pela mídia nos julgamentos do Tribunal do Júri, especialmente em relação ao Conselho de Sentença, composto por jurados. Alguns crimes ganham repercussão em nível nacional e a mídia conscientiza a sociedade e os jurados podem ser influenciados em suas decisões. Diante dessa realidade, este estudo tem como objetivo analisar a relação entre a influência da mídia no pré-julgamento de crimes dolosos que ameaçam a vida e suas consequências. Para tanto, será utilizada uma abordagem dedutiva, por meio de uma pesquisa qualitativa, em que os dados serão coletados por meio de técnicas de pesquisa bibliográfica. Diante dessa realidade, a importância deste estudo reside principalmente em demonstrar que a mídia se tornou um potencial passivo para a formação da opinião pública, influenciando as audiências por meio do sensacionalismo excessivo, e tendo um efeito prejudicial na divulgação de notícias, sobre o júri.
CRIMES HEDIONDOS: CONSEQUÊNCIAS NA FIXAÇÃO E CUMPRIMENTO DA PENA
Authors: Silva Roberto Alexandre Agripino da , Abreu Sergio Marcos de Brito
Published: June 2024

Crime hediondo é um termo utilizado no sistema jurídico brasileiro para se referir a crimes considerados extremamente graves e que, por isso, recebem um tratamento penal mais severo. A Lei nº 8.072/1990 lista vários crimes considerados como hediondos. No entanto, a Lei nº 13.964/2019, conhecida como “Pacote Anticrime”, trouxe mudanças significativas, incluindo o aumento do tempo mínimo de cumprimento de pena em regime fechado para crimes dessa natureza. Todavia, em que pese essas normas, há debates sobre a eficácia dessas medidas e suas implicações para o sistema penitenciário e os direitos humanos. Em razão disso, esse estudo teve a finalidade de discutir a respeito dos crimes hediondos, apresentando o debate acerca das consequências do cometimento desses crimes na fixação de pena e no seu cumprimento. No campo metodológico, foi realizada uma revisão bibliográfica, com fundamento em artigos científicos, livros, periódicos, jurisprudência e na legislação atual sobre o respectivo tema. A coleta de dados foi feita por meio de banco de dados tais como Scielo, Google Acadêmico, dentre outros, no período de 2018 a 2023. Nos resultados, o que ficou claro no decorrer do estudo é que a Lei dos Crimes Hediondos trouxe um regime mais rígido para crimes considerados extremamente graves, com o objetivo de aumentar a segurança pública e dissuadir a prática desses crimes. Já o Pacote Anticrime buscou modernizar e fortalecer o combate ao crime no Brasil. As medidas de endurecimento penal, como a restrição de benefícios, visam aumentar a eficiência do sistema de justiça criminal.
A NEGATIVA DOS PLANOS DE SAÚDE NOS TRATAMENTOS DE ALTO CUSTO, FACE AO PRINCÍPIO DA DIGNIDADE HUMANA
Authors: Santos Luiz Marcelo Gomes dos , Camargo Júnior Waldir Franco de
Published: June 2024

Este Trabalho de Conclusão de Curso tem como objetivo central de estudo a abordagem sobre a recusa dos planos de saúde em cobrir tratamentos de alto custo, um tema de grande relevância na sociedade contemporânea devido ao seu impacto direto no princípio da dignidade humana. Com o avanço da tecnologia na área da saúde, tais tratamentos se tornaram essenciais para a qualidade de vida e sobrevivência de muitos pacientes. No entanto, a recusa frequente dos planos de saúde em custear esses tratamentos levanta questões éticas e jurídicas, pois envolve a vida e a saúde das pessoas. O estudo busca compreender os motivos por trás dessas negativas, analisar suas consequências para os pacientes e refletir sobre o papel do Estado e da sociedade nesse contexto. A discussão se fundamenta no princípio da dignidade humana, reconhecido tanto pela Constituição Federal quanto por tratados internacionais, que garante o direito fundamental à saúde. Casos concretos de pacientes que tiveram seus direitos negados são analisados, evidenciando a necessidade de intervenção judicial para assegurar o acesso aos tratamentos necessários. Os debates doutrinários abrangem aspectos éticos, legais e econômicos, destacando a responsabilidade contratual dos planos de saúde, os critérios de cobertura, o impacto econômico e os direitos dos pacientes. Embora os planos de saúde se baseiem em fundamentos legais, é importante considerar que tais decisões podem ser contestadas à luz de considerações éticas e de direitos dos pacientes. Em suma, o artigo enfatiza a complexidade do tema e a necessidade de buscar soluções que garantam o acesso justo e igualitário aos tratamentos de alto custo, preservando a dignidade e os direitos dos pacientes. A intervenção do Poder Judiciário e a revisão dos critérios de cobertura são apontadas como medidas cruciais para alcançar uma sociedade mais justa e igualitária no acesso à saúde.
DIREITO AMBIENTAL NA ERA DO ANTROPOCENO
Authors: Lucena Beluze Andrade de
Published: June 2024

Esse trabalho visa analisar o resultado da ação do homem no meio ambiente e como isso repercute na efetividade do Direito Ambiental. Numa época denominada Antropoceno, que revela a humanidade numa busca desenfreada para satisfazer os anseios de consumo, mostra-se real a ameaça à existência do meio ambiente e, por conseguinte, da própria espécie humana.
DIFICULDADES DO ATENDIMENTO ENDODÔNTICO NO SUS – SISTEMA ÚNICO DE SAÚDE: UMA REVISÃO DE LITERATURA
Authors: Kruschewsky Larissa Souto Velloso , Freire Danielle Cardoso Albuquerque Maia
Published: June 2024

O sistema único de saúde (SUS) foi criado para garantir o acesso universal ao sistema público de saúde proporcionando uma atenção ampla a saúde indo além dos cuidados assistenciais, portando é um direito de todos os brasileiros em todas os estágios de vida. O programa Brasil sorridente se destina aos cuidados odontológicos dentro dos SUS. Ainda que destinado a  ações de prevenção e tratamentos básicoS, são também incluídos neste programa especialidades odontológicas como a endodontia .No Brasil, o setor de odontologia frente ao atendimento endodôntico evoluiu bastante nas últimas décadas, mas as inovações ficaram mais concentradas em exames e tratamentos para os pacientes, a tecnologia na odontologia está transformando a realidade dos consultórios e do trabalho dos dentistas, mas lamentavelmente decorrem problemas que dificultam esse atendimento nos três níveis de atenção à saúde. logo se faz necessário análise das dificuldades do atendimento endodôntico no SUS – sistema único de saúde. Nesse sentido, o objetivo dessa pesquisa foi averiguar e compreender a dificuldades do atendimento endodôntico no SUS. Para tanto, esta pesquisa revisou a bibliografia dos últimos 20 anos utilizando, artigos, dissertações, monografias e teses, publicadas nos disponíveis na Biblioteca Digital Brasileira de Teses e Dissertações (BDTD), no Google Acadêmico no Portal SCIELO (Scientific Eletronic Library Online e no Pubmed. Pode-se concluir com esta revisão que o SUS é um programa de saúde extremamente necessário para a população menos favorecida do nosso país, que o mesmo ainda algumas deficiências principalmente nos atendimentos especializados onde grande parcela da população ainda não consegue atendimento endodôntico de qualidade.
A DEPENDÊNCIA DA INDÚSTRIA AGRÍCOLA BRASILEIRA NO MERCADO EXTERIOR E AS POSSIBILIDADES DE AUTONOMIA
Authors: Santos Gabriel dos , Souza Yasmim Paulina Oliveira de , Sobrinho Osvaldo Esteves
Published: June 2024

Esta pesquisa aborda como tema os desafios que a indústria agrícola está passando, causados pela dependência à importação de máquinas agrícolas e peças produzidas fora do mercado nacional. O problema da dependência do mercado exterior prejudica a indústria brasileira, limitando a capacidade de inovação e desenvolvimento tecnológico, além de fortalecer a desnacionalização em nosso território. beneficiando as empresas internacionais e nos colocando em desvantagem competitiva. O objetivo principal deste trabalho, é analisar se existe a possibilidade de nos tornamos menos dependentes ao construir máquinas agrícolas internacionais, observar os métodos que tornam isso possível e como essa experiência foi produtiva no passado. Para fundamentar os dados deste projeto, foi utilizada a pesquisa bibliográfica, e que nos leva a algumas conclusões, mas também suscita algumas dúvidas, apresentadas ao final do trabalho. Ao fim, se chega ao resultado que é possível construirmos nossas máquinas agrícolas, e devemos encerrar essa dependência para conseguirmos diminuir os males e começar a investir no setor industrial agrícola. O trabalho conclui que essa dependência é um obstáculo ao desenvolvimento do setor industrial do Brasil, e que tomando exemplos de estratégias como o planejamento centralizado da China junto do incentivo do governo brasileiro, é possível revitalizar este setor. Mas ao término desse raciocínio, surgem algumas dúvidas que poderão ser respondidas a partir de um outro estudo e análise mais aprofundadas.
O RECONHECIMENTO DO COMPANHEIRO COMO HERDEIRO NECESSÁRIO E A REPERCUSSÃO NO DIREITO SUCESSÓRIO
Authors: Cordeiro Ayla Sabrina Oliveira , Costa João Santos da
Published: June 2024

O tema abordado no presente artigo é o reconhecimento do companheiro como herdeiro necessário e a repercussão no direito sucessório, com o objetivo de entender como funciona cada uma das pautas que levam à discussão referida, possibilitando entender como chegou-se à conclusão do parceiro ser ou não reconhecido como herdeiro necessário e quais impactos essa decisão causou no direito sucessório. Essa é uma discussão extremamente importante para que se possa entender acerca do direito sucessório, que tem como objetivo preservar e tutelar os direitos, deveres e mesmo os bens que um dia pertenceram a alguém, e que serão repassados para outra pessoa com o instituto da herança. No primeiro capítulo serão tratados temas acerca do direito sucessório e sucessão legitima no Brasil, bem como a exclusividade da tutela ao casamento e a repercussão da Lei 8.971/94 no que diz respeito à tutela sucessória de uniões não formalizadas no casamento. No segundo capítulo serão tratados temas como união estável, ordem de vocação hereditária e regras de concorrência entre cônjuges.
Decentralization, Blockchains, and the Development of Smart Communities in Economically Challenging Environments
Authors: Bourbon Brett , Murimi Renita
Published: June 2024

Current implementations of blockchain technologies for smart cities assume environments with ample socio-technical resources. In this paper, we analyze four particular cases to show how blockchains can be used to create smart communities within under-developed and resource-poor environments. In these contexts, blockchains were critical in developing and maintaining trust within the community while meeting specific social needs. Our analysis of these specific cases was then used to derive a definition of a “smart community”. We provide a schematic outline of the foundational elements for the development of smart communities using blockchain technology. The goal of our paper is to show that blockchains hold promise not just for building smart cities in resource-rich contexts, but also for building smart communities in resource-impoverished contexts using a bottom-up, problem-driven approach.
“We Need Structures in Place”: Educators’ Experiences With Special Education at International Schools
Authors: Stroud Rebecca
Published: June 2024

This article engages the construct of the policyscape to explore how educators have experienced policy-to-practice dissonances when working at international schools overseas. Extracted from a qualitative study of educator acculturation in the context of the lived experiences of 17 kindergarten–Grade 12 expatriate teachers, counsellors, and school leaders at international schools in five regions in Southeast and East Asia, this subset of findings explores the most prevalent policyscape manifestations that emerged in the study. These manifestations involve issues about supporting students with known or probable “special education” needs. Findings include widespread perceptions by the participants of inadequate policy and program infrastructure to properly support students with special needs. These inadequacies ranged from identification processes, school and staff capacity, and leadership gaps, and they were further mired by ideological and cultural differences noted by stakeholder groups. Participants with local cultural mentors experienced greater self-efficacy and leadership capacity in addressing the policyscape manifestations. The study was exploratory, with the findings informing a research agenda to further investigate some of the gaps that emerged in the findings.
Gaya Belajar Siswa Kelas III Sekolah Dasar Negeri 218/IX Talang Duku
Authors: Karin Karina , Hatim Magdad , Suryani Ida
Published: June 2024

Research on Learning Styles of Grade Three Students Introduction This research aims to explore the learning styles of grade three students at Sekolah Dasar Negeri 218/IX Talang Duku. The focus of this research is to understand the visual, auditory and kinesthetic learning styles of the students, and the impact of monotonous learning methods on their engagement. Type of Research This research is a descriptive qualitative research, which aims to provide a detailed understanding of students' learning styles. Data Collection The results of this study were obtained through: Observation, Interview, In-depth questionnaire, these techniques are carried out directly in the field to collect data from informants. Findings This research focused on the learning styles of third grade students at SD Negeri 218/IX Talang Duku. The results showed that students have varied learning styles, including visual, auditory, and kinesthetic preferences. Conclusion Based on the research results, it can be concluded that third grade students of SD Negeri 218/IX Talang Duku have diverse learning styles, including: Learning by listening to the teacher's explanation/seeing, Memorising by repeating reading, solving problems through discussion or group work, Actively engaging with the teacher and classmates, Taking notes on important subject matter.
Analysis of The Influence of Import Volumes, Dynamics of Import Varieties, and Pricing Policies on Country's Foreign Exchange Growth
Authors: Reza Aulia Muhammad , Kamar Karnawi , Diah Astuti Enny , Henri Kusnadi Iwan , Parida Parida
Published: June 2024

The objective of this research is to examine the factors that led to the cessation of imports of certain varieties after the crisis. This analysis proposes four alternative working hypotheses. Data from 100 products was taken. Several influencing factors reveal the impact of the economic crisis on imported varieties. More expensive varieties tend to experience an increased probability of stopping importation. This may be due to a decrease in purchasing power during the crisis, which makes expensive products less desirable. Geographic distance also plays an important role. More distant countries produce varieties with a higher probability of stopping imports, this could be due to higher transportation costs for varieties from distant countries. Varieties with a larger market share originating from countries with higher incomes tend to be more stable in the market during the crisis. Likewise, additional per capita income limits the probability of stopping imports to only 3.7%. This suggests that varieties from countries with high incomes or those with large market shares may have competitive advantages that make them more resilient to the impact of economic crises. Reducing imported varieties can hurt consumer welfare because it can reduce product choices and increase prices. Short-term estimates indicate a 9.5% decline in consumer welfare from imported goods.
Caracterización de los procesos cognitivos en estudiantes sordos chilenos y colombianos
Authors: Muñoz-Vilugrón Karina , Rodríguez Hernández Yenny , Sánchez Bravo Alejandra , Sastre-González Carmen
Published: June 2024

La educación para los estudiantes sordos está en un proceso continuo de revisión, la inclusión de este grupo minoritario es una realidad y un desafío en las aulas de clases. Este articulo tiene como objetivo caracterizar los procesos cognitivos en el aula de clases de estudiantes sordos colombianos y chilenos de educación básica/primaria. Esta es una investigación con enfoque cualitativo, con diseño de estudio de casos múltiples. Los participantes fueron organizados en términos de aulas inclusivas chilenas (sordos y oyentes) y exclusivas colombianas (solo estudiantes sordos) de los niveles 3º, 4º y 5º año. Se aplicó la Pauta de Observación de Procesos Cognitivos (POPC), la que se organiza en 4 dimensiones: Procesos Cognitivos, Procesos Metacognitivos, Aspectos Motivacionales y Actividades suplementarias. Además, se aplicó una entrevista semiestructurada a los docentes, intérpretes de Lengua de Señas y coeducadores sordos. Los resultados se plantean en función de la descripción de las estrategias pedagógicas que usan los profesores sordos y oyentes para promover procesos cognitivos en el aula, considerando diferentes diadas (estudiante sordo-docente sordo/oyente, estudiante sordo-estudiante oyente, estudiante sordo-intérprete) Las conclusiones apuntan a que las aulas inclusiva favorecen el trabajo colaborativo y el aula exclusiva desarrolla estrategias en la lengua de señas potenciando los aprendizajes de los estudiantes sordos.
Editorial - O pulsar da Academia: Temas médicos relevantes, a causa mortis de Cristo e os avanços (e curiosidades) da Imunologia reconhecidos com o Prêmio Nobel
Authors: Schwartsmann Gilberto
Published: June 2024

Nesta publicação dos Anais da Aca¬demia, trazemos artigos que abordam temas da prática médica, curiosidades de interesse médico e contribuições que aprofundam temas relacionados à imu¬nologia geral, muitas delas que levaram ao Prêmio Nobel, e às suas marcantes aplicações no tratamento do câncer.
Fogo de Prometeu
Authors: Schwartsmann Gilberto
Published: June 2024

Ao longo da história dos Prêmios Nobel de Fisiologia ou Medicina, os temas relacio¬nados à Imunologia têm sido muito presen¬tes. Por essa razão, a “Sessão Nobel”, realiza¬da no dia 19 de maio de 2022, na Academia Nacional de Medicina, sob a minha coorde¬nação, não poderia furtar-se da escolha dessa temática.
Dois equívocos e um funeral: o Prêmio Nobel de Fisiologia ou Medicina de 2011
Authors: André Barcinski Marcello
Published: June 2024

O presente texto discute o significado do Prêmio Nobel, em especial o de medicina, nominado como “Nobel Prize in Physiology or Medicine” pelo Comitê Nobel sediado em Estocolmo. É a maior distinção que um ou uma cientista pode receber, e a quase unanimidade dos agraciados fez por merece-lo. Assim sendo, a decisão é em geral bem aceita pela comunidade científica e o recipiente passa a ocupar posição de destaque entre seus pares.
Sessão “Nobel Laureates” na Academia Nacional de Medicina Complexo Principal de Histocompatibilidade e Reconhecimento Imunológico
Authors: Kalil Jorge
Published: June 2024

O autor descreve brevemente as des¬cobertas de quatro imunologistas laureados com o Prêmio Nobel de Fisiologia ou Medi¬cina por seus trabalhos sobre o determinis¬mo genético da identidade biológica dos in¬divíduos, definida pelo “Complexo Principal de Histocompatibilidade”, e a sua importân¬cia para o fenômeno descrito como restrição genética da resposta imune específica.
Jesus Cristo teria morrido de embolia pulmonar?
Authors: Arêas Marques Marcos , Araújo Zulchner Marina , de Castro Nunes Senfft Isabel , Gil Lopes Aníbal , Von Ristow Arno , Kepler Alvim Fiorelli Rossano , Luiz Malavasi Longo de Oliveira André
Published: June 2024

Este artigo se destina a analisar teo¬rias descritas por diferentes autores sobre as prováveis causas da morte de Jesus Cristo. Diante das hipóteses mais plausíveis, des¬tacam-se asfixia, tromboembolismo venoso e choque hipovolêmico. O objetivo desta revisão foi coletar dados relevantes da lite¬ratura que envolvem o assunto. Por se tra¬tar de um tema ainda não elucidado pela ciência, este artigo ganha relevância ao reu¬nir em um único trabalho as principais te¬orias relacionadas à causa mortis de Cristo.
Phytochemical Study of Green Meniran Herb (Phyllanthus niruri L.) and Red Meniran Herb (Phyllanthus urinaria L.) in Jekan Raya Sub-district of Palangka Raya City, Central Kalimantan Province
Authors: Damiti Sukmawati , Mashar Harlyanti Muthma’innah , Yusuf Baharuddin
Published: June 2024

Kalimantan is one of the islands in Indonesia that is famous for its rich biodiversity. Knowledge about the use of traditional medicine using plants has been passed down from generation to generation among the ethnic natives of Kalimantan. One of the typical Kalimantan plants that is efficacious as traditional medicine and contains various potential secondary metabolites is meniran. Based on ethnobotanical studies in Central Kalimantan, meniran is boiled to treat fever, dysentery, jaundice, malaria, therefore further research is needed for the chemical content of meniran which is efficacious. This study aims to determine the phytochemical of green meniran herb (Phyllanthus niruri L.) and red meniran herb (Phyllanthus urinaria L.). Determination of plant samples was carried out for both types of meniran. Then processing, extraction and identification of chemical content. The yield values of each extract obtained were 7.40% and 8.76%. As for the results of phytochemical studies, green and red meniran herb both contain alkaloid, tannins and flavanoids, but green meniran is indicated to have steroid content and red meniran contains triterpenes. Secondary metabolites possessed by these two types of meniran plants are beneficial for health, including as antioxidants, antibacterial, antiviral, anticancer and a number of pharmacological activities that are significant in improving one's health and minimizing the risk of infection by pathogens. However, further research is needed to test the activity of the content of these two types of meniran as a basis for the manufacture of traditional medicines.
Pengaruh Edukasi Bantuan Hidup Dasar dengan Media Booklet dan Roleplay terhadap Tingkat Pengetahuan dan Keterampilan Mahasiswa
Authors: Rinjani Putri Diyanah Syolihan , Nanda Novia Eka
Published: June 2024

Hilangnya fungsi jantung secara tiba-tiba, atau henti jantung, sebagian besar disebabkan oleh kerusakan pada sistem kelistrikan jantung. Bantuan Hidup Dasar(BHD) adalah salah satu metode penanganan henti jantung. BHD adalah perawatan cepat yang diberikan kepada korban henti jantung. Pada penelitian ini digunakan media roleplay dan booklet. Tujuan dari penelitian ini adalah untuk mengetahui bagaimana pengetahuan dan kemampuan siswa dipengaruhi oleh instruksi bantuan hidup dasar yang disampaikan melalui booklet dan media roleplay. Penelitian ini merupakan penelitian eksperimen semu yang menggunakan desain predan post test tanpa kontrol. Mahasiswa semester dua Universitas Kusuma Husada yang belum pernah mengambil mata kuliah BHD berpartisipasi dalam penelitian ini. Purposive sampling digunakan untuk memilih 74 responden dari populasi penelitian yang berjumlah 209 orang. Standar Operasional Prosedur (SOP) yang berkaitan dengan BHD dan kuesioner tingkat pengetahuan digunakan dalam proses pengumpulan data. Metode analisis uji Wilcoxon digunakan dalam penelitian ini. Uji Wilcoxon digunakan untuk mengevaluasi dampak dari tingkat keterampilan dan pengetahuan. H0 diterima karena analisis bivariat menggunakan uji Wilcoxon menunjukkan bahwa p = 0,000 < α = 0,05. Temuan penelitian ini menunjukkan bahwa tingkat pengetahuan dan kemampuan siswa dipengaruhi oleh instruksi bantuan hidup dasar yang disampaikan melalui booklet dan media roleplay.Sudden loss of heart function, or cardiac arrest, is mostly caused by damage to the heart's electrical system. Basic Life Support (BLS) is one method of treating cardiac arrest. BLS is the prompt treatment provided to victims of cardiac arrest. In this study, roleplay and booklet media were employed. The purpose of this study is to ascertain how students' knowledge and abilities are affected by basic life support instruction delivered through booklets and role-playing media. This study is a quasi-experiment that uses a control-free pre- and post-ttest design. Students from Kusuma Husada University's second semester who had never taken a BLS course participated in the research. Purposive sampling was used to select 74 respondents from the study's population of 209 individuals. Standard Operational Procedures (SOP) pertaining to BLS and a knowledge level questionnaire were employed in the data collection process. The Wilcoxon test analysis method is applied in this study. The Wilcoxon test is employed to evaluate the impact of skill and knowledge levels. H0 is accepted because bivariate analysis using the Wilcoxon test reveals that p = 0.000 <α = 0.05. The study's findings indicate that students' levels of knowledge and abilities are impacted by basic life support instruction delivered through booklets and role-playing media.
Acceptance of Hepatitis B Vaccine Among Health Care Workers in Ondo State
Authors: M. A. Olofin-Samuel , M. A. Aina , O. C. Ogidan , T. O. Ayedun , O. A. Gentry , O. Y. Adeagbo , V. I. Oyolola
Published: June 2024

Hepatitis-B Virus is a prevalent blood-borne disease that can be spread through occupational exposures. This study examines the acceptance of the Hepatitis B vaccine among healthcare workers in Akoko Senatorial District, Ondo State. This study utilised a cross-sectional descriptive research methodology to assess the adoption of the hepatitis B vaccine among healthcare workers in the Akoko senatorial district of Ondo state. The sample size was calculated using the Taro Yamane formula, resulting in 226. The participants were chosen from each of the research locations using convenience sampling technique. The data was gathered over a period of four weeks. The instrument used for data collection was a self-developed questionnaire. Only 218 questionnaires were completed accurately and were suitable for analysis. The data was analysed using Statistical Package for Social Sciences (SPSS) version 25. The hypothesis was tested using Pearson Product Moment Correlation at 0.05 level of significance. It was revealed that majority of the respondents had a strong grasp of important elements of Hepatitis B. Only 36 respondents has a positive and open attitude toward accepting the hepatitis B vaccine among this segment of the surveyed population. The listed factors influencing acceptance were vaccine accessibility, poor attitudes among vaccinators, crowded vaccination centers, and inadequate staff orientation. The findings also revealed a non-significant relationship between knowledge levels and vaccine acceptance. This implies that while knowledge is essential, it may not singularly drive vaccine acceptance, pointing to the need for comprehensive interventions. It is therefore recommended that Healthcare institutions and policymakers should work on optimizing the accessibility of vaccination services.
Proposed Integrated Solid Waste Recycling Model in Namibia
Authors: Mutede Tandiwe
Published: June 2024

This article presents a proposed recycling model in Namibia as a way of enhancing solid waste recycling. Scrap metal, plastic, paper, glass, electronic waste, and aluminium cans are recycled materials in Namibia. Face to face interviews, document evidence and site observations were used to qualitatively establish an understanding of recycling practices in the country. Despite its potential, a national study on solid waste recycling as an emerging industry in Namibia conducted in 2019 concluded that recycling of solid waste in the country was low and limited to major cities of Windhoek, Swakopmund and Walvis Bay. Efforts such as Clear Bag System, Schools Recycling Competitions and Awareness Campaigns were ongoing at the time of study to promote more recycling. Recycling was found to be plagued with a number of challenges, thus struggling to achieve intended goals of raw material production as well as addressing waste management problems that the country faced. Behind this backdrop, a proposed Integrated Recycling Model for Namibia was developed which would assist, if implemented, with the resolution of some of the challenges that were identified.
Dampak Penghargaan Finansial dan Disiplin Atas Kepuasan Kerja Karyawan
Authors: Renata Dafa Angri , Pramadewi Arwinence , Junaidi Rahmat
Published: June 2024

Jantra Radja Persada is a firm that specializes in producing and distributing bottled drinking water (AMDK). It is situated in Tembilahan City, Indragiri Hilir Regency, Riau Province, Indonesia. The research was carried out at CV. Jantra Radja Persada Tembilahan located on Ahmad Yani Street. The objective of this study is to ascertain the impact of financial contentment and work discipline on employee satisfaction with their employment. This research is of a quantitative nature. The study included a population of 36 employees from CV firm, Jantra Radja Persada, located in Tembilahan, Riau Province. The sample used in this study consisted of the complete population, specifically 36 individuals. The investigation employed a saturation sampling strategy. This study employs multiple linear regression analysis with the utilization of SPSS version 25 software. The findings of this study indicate that financial remuneration has a favorable and substantial impact on employee job satisfaction. Additionally, work discipline also has a positive and significant influence on employee job satisfaction. Moreover, the variables of financial reward and work discipline collectively exert a positive and significant effect on employee job satisfaction. Based on this research, it can be inferred that both financial funding and work discipline exert a favorable and substantial impact on employee job satisfaction at CV. Jantra Radja Persada Tembilahan, located in Riau Province. These findings demonstrate the significance of efficient human resource management in enhancing employee work satisfaction. This research suggests that organizations should prioritize financial savings measures and promote strong work discipline in order to enhance employee job satisfaction. By implementing this approach, firms can provide a conducive work atmosphere that fosters employee motivation and enhances their performance.
Pengaruh Ekonomi Energi Terhadap Intensitas Emisi Co2 dalam Merepresentasikan Sustainable Development Goals (SGDS)
Authors: Setyo Asmoro Gilang
Published: June 2024

Tujuan penelitian ini adalah untuk mengetahui pengaruh antara Foreign Direct Invesment, Jumlah konsumsi energi Listrik, Total populasi penduduk, dan Gross Domestic Product (GDP) terhadap intensitas Emisi CO2 atau Emisi Karbondioksida dalam kurun waktu pada tahun 1994 sampai tahun 2019 di Negara Indonesia, yang nantinya dapat menjadi acuan dalam melakukan Pembangunan untuk mencapai Sustainable Development Goals (SDGs) di Negara Indonesia. Variabel independen dalam penelitian ini yaitu Foreign Direct Invesment, Jumlah konsumsi energi Listrik, Total populasi penduduk, dan Gross Domestic Product kemudian variabel dependen yaitu Intensitas Emisi CO2 atau Emisi Karbondioksida. Metode dalam pengumpulan data dalam penelitian ini menggunakan data sekunder bertipe time series pada tahun 1994 hingga tahun 2019. Metode penelitian yang digunakan adalah Ordinary Least Square (OLS) regresi model linier. Hasil analisis menunjukkan bahwa variabel independen jumlah konsumsi energi Listrik berpengaruh dan signifikan terhadap intensitas karbondioksida kemudian total populasi penduduk berpengaruh dan signifikan terhadap intensitas karbondioksida, variabel independen Foreign Direct Invesment dan Gross Domestic Product tidak berpengaruh signifikan terhadap intensitas Emisi CO2 atau Emisi karbondioksida.
Method Development and Validation of Irbesartan by RP-HPLC
Authors: Chechare D.D. , Thombare Y.R. , Shinde S.S. , Mhaske N.S. , Khaire R.D.
Published: June 2024

A simple, sensitive, rapid and selective isocratic reversed phase High Performance Liquid Chromatographic (HPLC) method has been developed for Irbesartan from bulk drug using a mobile phase consisting mixture of Menthanol: Water (pH 2.8) (80:20v/v) at the flow rate of 1.0 mL/min. A Cosmosil C18 (250cm x 4.6mm, 5μm) column was used as stationary phase. The retention time of Irbesartan found to be 3.30 min. The eluent were detected at 209nm. Linearity was observed in the concentration range of 60-100ppm for Irbesartan. Percent recoveries obtained for Irbesartan were 98.66%. The correlation coefficient for Irbesartan was found to be 0.997. After performing analysis by different analysts, it was found that the RPHPLC method for the determination of Irbesartan was found to be Rugged. Percent RSD for robustness was well within the acceptable USP limits, ensuring that the proposed method was robust. The LOD were 0.074ug/ml Irbesartan. For Irbesartan, the LOQ were found to be 0.24μg/ml. This demonstrated that the developed RP-HPLC method was simple, linear, precise, accurate, robust, and Rugged, could be conveniently adopted for the routine quality control analysis of Irbesartan.
Development of Sustained Release Oral Floating Tablet Formulation of Cinnarizine using 32 factorial design
Authors: Solanki Himanshu , Desai Harsh , Singh Sumit , Naik Jai
Published: June 2024

The objective of this research is to develop a single unit capsule containing dual release gastro- retentive floating tablet of cinnarizine using polymers such as HPMC as a matrix forming agent, Ethyl cellulose as release retarding agent and Sodium bicarbonate as gas generating agent. Dual release consists of immediate release dose (IR) (loading dose) 25mg of cinnarizine in powder form and 50mg of sustain release tablet (maintenance dose) that will give drug release up to 12hr. The only target was to increase the gastric residence time by using floating approach, thus leading to increase in bioavailability. The direct compression method was used to create the initial batches of the medication, polymers, gas producing agent, and diluent. 32 factorial design was used to optimize the ingredient level. The optimized batches then were characterized for various parameters such as weight variation, thickness, hardness, Floating lag time, swelling study, FTIR etc. It was found that IR (loading dose) while SR of cinnarizine exhibited more than 80% drug release till 12hr. FTIR studies reveled that the drug was compatible with all other excipients. Through optimization, it was concluded that the amount of polymer and gas generating agent directly affect floating lag time and % drug release. SR tablet of cinnarizine of batch F5 showed drug release more than 99% in 12 hr. Thus, the tablet was then packed in capsule and stored at proper conditions.
Incorporation of Antihypertensive Class IV Drug in Novel Buccal Film Formulation
Authors: Yelave Adesh , Sameer Bhagwat Geeta , Rehmatullah Siddique Adnan
Published: June 2024

Chlorthalidone is a thiazide-like diuretic drug used in the treatment of hypertension. It belongs to class IV of Biopharmaceutical Classification System (BCS) and exhibits first pass metabolism leading to low bioavailability. The present work was undertaken to formulate mucoadhesive buccal film of chlorthalidone with an objective to improve bioavailability, therapeutic efficacy, and patient compliance. Film formulations were prepared by solvent casting method using a combination of different grades of hydrophilic polymer, Hydroxypropyl methylcellulose with suitable plasticizer. Other important excipients used were solubilizing agents to increase solubility and permeation enhancers to increase the permeability of the drug. The developed films were evaluated for physicochemical characteristics such as thickness, content uniformity, surface pH, and in vitro drug release etc. The optimized formulation containing a combination of hydrophilic and hydrophobic polymers showed good tensile strength, mucoadhesive strength and optimum in vitro diffusion results. The Ex vivo Drug permeation through porcine oral mucosa at the end of 8 hours was found to be 87.2±0.93%.
In-silico Investigation and ADMET Prediction of Potential Antifungal Phytochemicals against Lanosterol 14-Alpha Demethylase Inhibitors
Authors: A. Shinde Shalini , J. Mhetar Manasi , G. Parit Avantika , R. Thombre Akash
Published: June 2024

Mycosis is a chronic infectious disorder caused by various fungi affecting about 5% of the worldwide population. Pathogenesis involves the primary contact or inhalational roué for transmission. The infection is caused by to encoding of CYP450 enzyme Lanosterol 14-alpha demethylase. Numerous inhibitors are already used in clinical settings as therapeutic targets. A human lanosterol protein target (PDB ID: 6UEZ) and phytochemicals ligand library were used in a molecular docking simulation to perform docking simulation and ADMET studies on selected phytochemicals against human lanosterol protein receptor for drug discovery against lanosterol 14-alpha demethylase. The protein's crystal structure was retrieved and developed from the protein data repository with the aid of Biovia Discovery Studio. The phytochemicals' chemical structures were generated using Open Babel and VConf software after being downloaded from the NCBI PubChem database. PyRx was used to do molecular docking on Autodock Vina. SwissADME and pkCSM web servers were used to compute the best-performing compounds' ADMET characteristics. The findings demonstrated that taraxasterol exhibits a greater binding affinity. According to the findings, these compounds may be able to create anti-fungal activity, have decreased toxicity, and have easy absorbability at the tissue site, according to an ADME analysis. As a result, these substances can be examined in more in vitro research and could play a key role in developing a potential medicine to treat fungus infections.
Ethosomes: A Novel Tool for Vesicular Drug Delivery
Authors: U. Jadhav Pallavi , G. Gujare Sandhya , A. Shende Mulchand
Published: June 2024

Ethosomes are elastic, phospholipid-based nanovesicles with a high concentration of ethanol (20-45%). Ethosomes exhibit desirable features as vesicular systems. As a result of their bilayer composition (aqueous and lipid), they exhibit improved bioavailability for both hydrophilic and lipophilic drugs. Higher ethanol concentrations (30–45%) cause stearic stability, which allows the loaded medication to penetrate deeper into the stratum corneum, and deeper skin layers with a high transdermal flux. Due to the ease of preparation. non-irritancy, efficiency to encapsulate wide range of drug molecules with varying lipophilicity/hydrophilicity and higher stability than previously formulated other vesicular systems ethosomes are the optimal carriers for topical drug delivery. The use of ethosomal transporter opens up a variety of challenges and opportunities for researchers for future study and the creation of novel, superior treatments. The scope of this small review is to elaborate on the novel concept of ethosomes and to describe their methods of preparation, mechanism of penetration, composition, characterization, marketed products of ethosomes, patents and their applications.
Intranasal Drug Delivery: A Non-Invasive Method for improving Neurotherapeutic Delivery
Authors: G. Khope Rashmi , C. Gotmare Shruti , N. Dhoble Nilakshi , N. Padole Nitin , Dhapke Pankaj , R. Baheti Jagdish
Published: June 2024

New nanotechnology tactics to enhance drug delivery to the central nervous system have drawn increasing attention from academics and drug designers in recent years (CNS). The treatment of neurological conditions, including Alzheimer's disease, Parkinson's disease, brain tumours, and stroke, has a significant deal of potential to be impacted by nanotechnology. Numerous investigations on the topic of neurodegeneration revealed that CNS illnesses have been successfully treated with nanomaterials. Nanocarriers have made it possible to transport chemotherapeutics to specific locations, which has effectively slowed the growth of malignant brain tumours. The treatment of CNS diseases, which improves the overall effect of medication and emphasises the significance of nano-therapeutics, is thus the most effective application of nanomaterials. In order to transport therapeutic agents to the CNS, this study was done to analyse the data on the use of nanotechnology in the design of drug delivery systems that can pass through the blood-brain barrier (BBB).
Pyranopyrimidine: A Promising Scaffold with various Biological activities
Authors: Pooja G. Sathya , Banupriya S.
Published: June 2024

Heterocyclic compounds are one of the most important molecules in the synthesis of pharmacologically active compounds. One of the most promising heterocycles among all is the pyranopyrimidine scaffold, that has been found in both natural and synthetic sources. It has been confirmed to possess a range of biological activity, including anti-HIV, anti-tubercular, anti-HBV, anti-dyslipidemic, anti-platelet, anti-inflammatory, antioxidant, and antibacterial properties. The objective of this review is to highlight significant pyranopyrimidine analogues with a range of biological activity.
ТЕОРЕТИЧНІ ПЕРЕДУМОВИ ТА ЗАСАДНИЧІ ПРИНЦИПИ ХАОЛОГІЧНОГО АНАЛІЗУ ХУДОЖНЬОГО ТЕКСТУ
Authors: БЄЛЯКОВ О. О. , ШКАМАРДА О. А.
Published: June 2024

Стаття містить аналіз теоретичних передумов і засадничих принципів хаологічного аналізу художньої прози. Матеріалом дослідження обрані твори Джеймса Джойса (збірка оповідань «Дублінці» і роман «Тризна за Фіннеганом»). Продемонстровані перспективи екстраполяції хаології (теорії хаосу або хаотики) на сферу літературознавчої критики та інтерпретації художнього тексту. Теоретичним фундаментом дослідження послужили концепції Ф. Куберського, Д. Поруш, Х. Хокінс, Т. Дж Райса, Н. К. Гейлз, У. Еко та П. Стойчева. У статті наголошується, що хаологія дозволяє, по-перше, аналізувати твори, в яких хаос і лад, передбачуваність і непередбачуваність, стабільність і нестабільність, «мерехтіння смислу» і безмежність інтерпретацій набувають статусу тематичної і концептуальної домінанти. По-друге, хаологія відкриває можливість подолати просторово-часову дихотомію художнього твору і, таким чином, розкрити його евристичний потенціал. По-третє, аналіз художньої літератури, зокрема, прози Джеймса Джойса, допоможе змінити аналітичну оптику і висвітлити в ній такі характеристики художніх творів, які досі залишаються поза увагою дослідників. Оповідання збірки Дж. Джойса «Дублінці» описуються у дослідженні як нелінійні динамічні системи. Такі явища як біфуркація, атрактор і фрактальність визначаються задумом (прагматичною установкою) автора. «Тризна за Фіннеганом» Дж. Джойса генерує базові характеристики хаотичної дисипативної структури, а саме: нелінійність, незворотність, авторефлексивність і самоорганізація. Синергетичний ефект цього твору залежить (серед інших чинників) від кореляції між синтаксичною структурою, яка виконує функцію репелерів, і лексичними елементами, які набувають ознак атракторів. У «Дублінцях» має місце процес актуалізації впорядкованості, тоді як хаос має вторинний характер і є наслідком цієї актуалізації. У «Тризні за Фіннеганом» хаотичні, дестабілізуючі процеси займають домінуючу і визначальну позицію, а впорядкованість формується в залежності від тих критеріїв, які встановлює (або якими керується) читач у процесі рецепції цього твору. У широкому історичному контексті еволюцію прози Дж. Джойса можна описати, користуючись метафорою «ефект метелика»: від простих початкових елементів і умов (ознаки класичного наративу у «Дублінцях») до тієї нелінійної динамічної системи, яку Дж. Джойс назвав у «Тризні за Фіннеганом» «хаосмосом».
Molecular characteristics of left-sided, advanced stage colorectal cancer: A Mexican perspective
Authors:   Department of Anatomical Pathology, National Institute of Medical Sciences and Nutrition Salvador Zubirán, Mexico City, Mexico., Maria José Lizardo-Thiebaud , Braulio Martínez-Benítez ,   Department of Anatomical Pathology, National Institute of Medical Sciences and Nutrition Salvador Zubirán, Mexico City, Mexico., Jean Martínez-Nava ,   Department of Anatomical Pathology, National Institute of Medical Sciences and Nutrition Salvador Zubirán, Mexico City, Mexico., Rafae Medrano Guzmán ,   Department of Anatomical Pathology, National Institute of Medical Sciences and Nutrition Salvador Zubirán, Mexico City, Mexico., González María Guadalupe Jazmín De Anda ,   Department of Anatomical Pathology, National Institute of Medical Sciences and Nutrition Salvador Zubirán, Mexico City, Mexico.
Published: June 2024

Background: Predictive molecular markers based on the consensus molecular classification of colorectal carcinoma are tested following expert recommendations. Specifically, they are tested when target molecular therapy is being considered for treatment. Their presence depends on biology but their frequency seems to be increased in advanced stages. Objective: We developed a study of cases of left-sided CRC in advanced clinical stages from a cohort of Mexican patients to evaluate the presence of predictive molecular markers. Method: Predictive molecular markers were analyzed, including BRAF, KRAS, NRAS and mismatch repair genes, in cases of advanced, left-sided colorectal carcinoma.
Some Open Problems in the Symmetry of Graphs
Authors: Marusic Dragan
Published: June 2024

When dealing with symmetry properties of combinatorial objects, such as vertex-transitive (di)graphs, a fundamental question is to determine their full automorphism group. Many of these objects naturally display certain inherently obvious symmetries. It is often the case, however, that additional symmetries, though hidden or difficult to grasp, are present.

When this is the case, the goal is to find a reason for their existence and a method for their description.

A simple yet non/trivial question along these lines concerns the dichotomy of _even/odd automorphisms_, wherean automorphism of a graph X is said to be _odd_ (resp. _even_) if it acts as an odd (resp. even) permutation on the vertex set of X.

Deciding in general whether a given (vertex-transitive) graph has odd automorphisms or not is indeed a non-trivial problem.

For example, one of the consequences of the classification of finite simple groups (CFSG) is that A_5 and S_5 are the only simply primitive groups of degree twice a prime number. Therefore, the Petersen graph and its complement are the only examples of connected vertex-transitive graphs of order twice a prime number with a simply primitive automorphism group. Consequently, every such graph has an odd automorphism. I am aware of no CFSG-free proof of this result to exist.

This brings us to the second goal of this talk: we will discuss possibile ways of replacing exisisting proofs of certain results in algebraic graph theory, that rely on CFSG, with direct arguments.

Most of the results discussed in this talk are joint with my colleagues from the University of Primorska: Ademir Hujdurović, Klavdija Kutnar and Stefko Miklavič.