bluuebunny/crossref_metadata_2025 huggingface dataset:
TrendNets: mapping emerging research trends from dynamic co-word networks via sparse representation
Authors: Katsurai Marie , Ono Shunsuke
Published: October 2019

Mapping the knowledge structure from word co-occurrences in a collection of academic papers has been widely used to provide insight into the topic evolution in an arbitrary research field. In a traditional approach, the paper collection is first divided into temporal subsets, and then a co-word network is independently depicted in a 2D map to characterize each period’s trend. To effectively map emerging research trends from such a time-series of co-word networks, this paper presents TrendNets, a novel visualization methodology that highlights the rapid changes in edge weights over time. Specifically, we formulated a new convex optimization framework that decomposes the matrix constructed from dynamic co-word networks into a smooth part and a sparse part: the former represents stationary research topics, while the latter corresponds to bursty research topics. Simulation results on synthetic data demonstrated that our matrix decomposition approach achieved the best burst detection performance over four baseline methods. In experiments conducted using papers published in the past 16 years at three conferences in different fields, we showed the effectiveness of TrendNets compared to the traditional co-word representation. We have made our codes available on the Web to encourage scientific mapping in all research fields.
Return to Sport after Coracoid Bone Block Transfer for Shoulder Instability: A Systematic Review
Authors: Nadeem Ibrahim M. , Vancolen Seline , Horner Nolan S. , Bedi Asheesh , Alolabi Bashar , Khan Moin
Published: October 2019

Background

Shoulder dislocations can be devastating for an athlete. Coracoid bone block transfer is often used for the treatment of recurrent shoulder instability.

Questions/Purposes

The primary purpose of this study was to determine the rate and mean time of return to sport in athletes after a coracoid bone block transfer at the pre-operative level of competition, a lower level, or a different level. We also sought to determine how return to sport rates after a coracoid bone block procedure compared with rates after several comparator interventions. Finally, we looked to determine the post-operative clinical outcomes and complications reported after a coracoid bone block procedure.

Methods

We systematically searched three databases (PubMed, Embase, and MEDLINE) for studies reporting return to sport after a coracoid bone block procedure.

Results

A total of 52 studies (with levels of evidence ranging from II to IV) evaluating 2953 shoulders in 2888 patients were included in this systematic review. The mean rate of return to sport at any level was 88.4% (2291 of 2592 patients). However, the rate of return to the pre-operative level was 70.3% (1387 of 1974 patients). The mean time to return to sport was 5.38 months (range 21 days to 36 months). The rate of return to sport was higher after the Latarjet procedure, as compared with Bankart repair (87.0% and 75.8%, respectively). All studies showed improvements in clinical outcome measures after coracoid bone block intervention. The cumulative complication rate was found to be 6.46% (158 of 2446 patients).

Conclusion

Coracoid bone block transfer allows for a high rate of return to sport, although the rate of return to sport at athletes’ pre-operative level is lower. The rate of return to sport after Latarjet procedure is higher in comparison with Bankart repair. Additionally, coracoid bone block transfer is associated with improvements in a number of clinical outcome measures. Common post-operative complications include non-union between bone block and glenoid, hematoma, and infection.
Effects of soil nutrient availability and ozone on container-grown Japanese larch seedlings and role of soil microbes
Authors: Agathokleous Evgenios , Kitao Mitsutoshi , Komatsu Masabumi , Tamai Yutaka , Saito Hideyuki , Harayama Hisanori , Uemura Akira , Tobita Hiroyuki , Koike Takayoshi
Published: October 2019

The interactive effects of ozone, soil nutrient availability and root microorganisms on physiological, growth, and productivity traits were studied for the first time for Japanese larch (Larix kaempferi) seedlings grown in containers over a growing season, using a free air ozone-concentration enrichment exposure system. High nutrient availability altered leaf and root nutrient dynamics and enhanced plant growth; however, it also enhanced seedling susceptibility to damping-off disease compared to low nutrient availability. Negative effects of elevated ozone, as compared with ambient ozone, on leaf gas exchange and plant stem form were neither offset nor exacerbated by soil nutrient availability and root colonizers. Such negative effects suggest that elevated ozone may have implications for ecological health even when plant vigor is limited by factors other than ozone. Inoculation of roots with ectomycorrhizae had negligible influence on the effects of either soil nutrient availability or ozone. However, this lack of effect may be upon impeded formation of complete mycorrhizal root tips due to factors other than the manipulated variables. B and Na appeared to have an important role in stress responses, so further studies to examine their link with physiological mechanisms as a function of time. This study provides an important perspective for designing forestry practices to enhance seedling health.
Immunohistochemical Characterization of Reactive Epithelial Changes in Odontogenic Keratocysts
Authors: Cserni Dorottya , Zombori Tamás , Stájer Anette , Rimovszki Annamária , Cserni Gábor , Baráth Zoltán
Published: October 2019

Odontogenic keratocysts (OKCs) have a diagnostic thin epithelial lining characterised by a linear epithelial connective tissue interface generally lacking inflammatory changes, basal palisading of the nuclei and a wavy parakeratotic layer on the surface. This typical epithelium may convert to a thicker non-keratinizing one with rete pegs and a relatively flat surface after operative decompression. The aim was to characterize this type of epithelial change by immunohistochemistry for bcl2, keratin17, 10 and 19. Eleven out of 33 archived OKCs demonstrated an altered epithelium related to previous biopsy, decompressing drainage or inflammation. The typical basal bcl2 staining was lost in 10/11 cases; transepithelial CK17 was lost or markedly reduced in 9/11 cases. CK10 displayed a segmental upper layer staining in OKCs, and its loss or partial loss in the altered epithelium did not differ from negative areas of OKCs. CK19 displayed various staining patterns in the altered epithelium from lost to maintained in a patchy transepithelial distribution, the latter of which did not differ from the typical OKC staining pattern. Three of four non-keratinizing epithelial linings with basal palisading displayed immunostaining reminiscent of typical OKC epithelium. The lack of a typical epithelium is not sufficient to exclude the diagnosis of OKC if the sampling is not generous (e.g. biopsy), and the presence of non-keratinizing epithelium with basal palisading and an immunophenotype characteristic of OKC (basal bcl2, patchy or diffuse CK17 and upper layer CK10 positivity) may be consistent with the OKC diagnosis even in the absence of typical epithelial lining.
Rokhlin dimension: duality, tracial properties, and crossed products
Authors: GARDELLA EUSEBIO , HIRSHBERG ILAN , SANTIAGO LUIS
Published: October 2019

We study compact group actions with finite Rokhlin dimension, particularly in relation to crossed products. For example, we characterize the duals of such actions, generalizing previous partial results for the Rokhlin property. As an application, we determine the ideal structure of their crossed products. Under the assumption of so-called commuting towers, we show that taking crossed products by such actions preserves a number of relevant classes of$C^{\ast }$-algebras, including:$D$-absorbing$C^{\ast }$-algebras, where$D$is a strongly self-absorbing$C^{\ast }$-algebra; stable$C^{\ast }$-algebras;$C^{\ast }$-algebras with finite nuclear dimension (or decomposition rank);$C^{\ast }$-algebras with finite stable rank (or real rank); and$C^{\ast }$-algebras whose$K$-theory is either trivial, rational, or$n$-divisible for$n\in \mathbb{N}$. The combination of nuclearity and the universal coefficient theorem (UCT) is also shown to be preserved by these actions. Some of these results are new even in the well-studied case of the Rokhlin property. Additionally, and under some technical assumptions, we show that finite Rokhlin dimension with commuting towers implies the (weak) tracial Rokhlin property. At the core of our arguments is a certain local approximation of the crossed product by a continuous$C(X)$-algebra with fibers that are stably isomorphic to the underlying algebra. The space$X$is computed in some cases of interest, and we use its description to construct a$\mathbb{Z}_{2}$-action on a unital AF-algebra and on a unital Kirchberg algebra satisfying the UCT, whose Rokhlin dimensions with and without commuting towers are finite but do not agree.
Generation of mode 2 internal waves by the interaction of mode 1 waves with topography
Authors: Liu Zihua , Grimshaw Roger , Johnson Edward
Published: October 2019

Oceanic internal waves can be decomposed into an infinite set of modes, and the dominant internal mode 1 waves have been extensively investigated. Although mode 2 waves have been observed, they have not received comparable attention, especially the generation mechanisms. In this work, we examine the generation of mode 2 internal waves by the interaction of mode 1 waves with topography. We use a coupled linear long-wave theory with mode coupling through topography, combined with evolution using a Korteweg–de Vries model, to predict the mode 2 wave amplitude, in an ideal three-layer fluid model, in a smooth density stratification and in two realistic oceanic settings. We find that the mode 2 wave amplitude is usually much smaller than the incident mode 1 wave amplitude and is quite sensitive to the pycnocline thickness, topographic slope and background stratification.
Mean dynamics and transition to turbulence in oscillatory channel flow
Authors: Ebadi Alireza , White Christopher M. , Pond Ian , Dubief Yves
Published: October 2019

The mean dynamics in oscillatory channel flow is examined to investigate the dynamical mechanisms underlying the transition to turbulence in oscillatory wall-bounded flow. The analyses employ direct numerical simulation data acquired at three Stokes Reynolds numbers: $Re_{s}=648$, 801 and 1009, where the lower $Re_{s}$ flow is transitional over the entire cycle and the two higher $Re_{s}$ flows exhibit flow characteristics similar to steady turbulent wall-bounded flow during part of the cycle. The flow evolution over a half-period of oscillation for all three $Re_{s}$ is as follows: near-wall streamwise velocity streaks develop during the early accelerating portion of the cycle; then at some later point in the cycle that depends on $Re_{s}$, the near-wall streaks breakdown (demarking the onset of the nonlinear development stage), and the near-wall Reynolds stress grows explosively; the Reynolds stress remains elevated for part of the cycle before diminishing (yet remaining finite) during the late decelerating portion of the cycle. This process is then repeated indefinitely. The present findings demonstrate that transition to turbulence occurs when the nonlinear development stage begins during the accelerating portion of the cycle. This crucially leads to the diminishing importance of the centreline momentum source, the emergence of a locally accelerating/decelerating internal layer centred about the edge of the Stokes layer and the wall-normal rearrangement of the mean forces prior to the start of the decelerating portion of the cycle. The rearrangement of mean forces culminates in a four layer structure in the mean balance of forces. This is significant on a number of accounts since empirical and theoretical evidence suggests that the formation of a four layer structure is an important characteristic of a self-similar hierarchal structure that underlies logarithmic dependence of the mean velocity profile in steady turbulent wall-bounded flows (Klewicki et al., J. Fluid Mech., vol. 638, 2009, pp. 73–93). When the nonlinear development stage begins during the decelerating portion of the cycle (i.e. at $Re_{s}=648$), a four layer structure is not observed in the mean balance of forces and the flow remains weakly transitional over the entire cycle.
Density effects on post-shock turbulence structure and dynamics
Authors: Tian Yifeng , Jaberi Farhad A. , Livescu Daniel
Published: October 2019

Turbulence structure resulting from multi-fluid or multi-species, variable-density isotropic turbulence interaction with a Mach 2 shock is studied using turbulence-resolving shock-capturing simulations and Eulerian (grid) and Lagrangian (particle) methods. The complex roles that density plays in the modification of turbulence by the shock wave are identified. Statistical analyses of the velocity gradient tensor (VGT) show that density variations significantly change the turbulence structure and flow topology. Specifically, a stronger symmetrization of the joint probability density function (PDF) of second and third invariants of the anisotropic VGT, PDF$(Q^{\ast },R^{\ast })$, as well as the PDF of the vortex stretching contribution to the enstrophy equation, are observed in the multi-species case. Furthermore, subsequent to the interaction with the shock, turbulent statistics also acquire a differential distribution in regions having different densities. This results in a nearly symmetric PDF$(Q^{\ast },R^{\ast })$ in heavy-fluid regions, while the light-fluid regions retain the characteristic tear-drop shape. To understand this behaviour and the return to ‘standard’ turbulence structure as the flow evolves away from the shock, Lagrangian dynamics of the VGT and its invariants is studied by considering particle residence times and conditional particle variables in different flow regions. The pressure Hessian contributions to the VGT invariants transport equations are shown to be not only affected by the shock wave, but also by the density in the multi-fluid case, making them critically important to the flow dynamics and turbulence structure.
Experimental investigation of the wave-induced motion of and force distribution along a flexible stem
Authors: Jacobsen Niels G. , Bakker Wout , Uijttewaal Wim S. J. , Uittenbogaard Rob
Published: October 2019

The work presents an experimental investigation into the motion of and hydrodynamic forces along a single flexible stem in regular waves. The experiment covers a large range in relevant non-dimensional parameters: the drag-to-stiffness ratio $CaL\in [0.003,3.8]$, the inertia-to-stiffness ratio $CaL/KC\in [4\times 10^{-5},14.8]$, the Keulegan–Carpenter number $KC\in [3.8,145]$ and the Reynolds number $Re\in [230,2900]$. The two first parameters relate to the response of the stem in waves and thus account for material properties, while the two last parameters are relevant for hydrodynamic forces on the stem. The displacement of the stem was captured with a digital video camera and the displacement along the stem was captured for every 2.5 mm at 25 Hz. This unique laboratory data set allowed for the following analyses: (i) Determination of the relevant non-dimensional parameter to predict the stem motion and shape. (ii) A direct comparison between the measured force for mimics of two lengths (0.15 m and 0.30 m) illustrating the force reduction potential for flexible mimics. (iii) Direct evaluation of the average force coefficients $C_{D}$ (drag) and $C_{M}$ (inertia) for the flexible stems. (iv) The distributed external hydrodynamic loading and the internal shear forces were estimated from the laboratory experiments. The distribution of the shear force helped to understand the breakage mechanisms of flexible stems. (v) A linkage between phase lags and internal shear forces was suggested. The data set is considered valuable as validation material for numerical models of stem motion in waves.
Innovation and Entrepreneurship in India: An Overview
Authors: Bhagavatula Suresh , Mudambi Ram , Murmann Johann Peter
Published: October 2019

India began the process of market liberalization that opened it to significant interactions with the world economy in 1991. In this essay, we provide an overarching view of the country's journey toward integration with the global innovation and entrepreneurship network. Major nodes in this global network have two major components that may be metaphorically referred to as ‘pillars and ivy’. Globally connected multinational enterprises (MNEs) form the pillars. Agile startups are the ivy, and their success (metaphorically, the height to which they can climb) depends on their symbiotic connections with the pillar MNEs. Both components are essential and reinforce each other. Without MNEs, the scaling of startups is hampered. Without a vibrant population of startups, MNEs’ interest in a location remains driven by cost, rather than capability and creativity. MNEs (mainly foreign) provided the initial sparks for the formation of the Indian innovation and entrepreneurship ecosystem. We chart the subsequent growth of India's startups. They began in the information technology (IT) sector but now cover a much wider range of industries. Today, India's innovation and entrepreneurship ecosystem is one of the largest in the world, with global integration in terms of technology, financing, human capital, and administration.
Submerged paleoshoreline mapping using high-resolution Chirp sub-bottom data, Northern Channel Islands platform, California, USA
Authors: Laws Alexander W. , Maloney Jillian M. , Klotsko Shannon , Gusick Amy E. , Braje Todd J. , Ball David
Published: October 2019

High-resolution Chirp sub-bottom data were obtained offshore from the Northern Channel Islands (NCI), California, to image submerged paleoshorelines and assess local uplift rates. Although modern bathymetry is often used for modeling paleoshorelines, Chirp data image paleoshorelines buried beneath sediment that obscures their seafloor expression. The NCI were a unified landmass during the last glacial maximum (LGM; ~20 ka), when eustatic sea level was ~120 m lower than present. We identified seven paleoshorelines, ranging from ~28 to 104 m in depth, across this now-submerged LGM platform. Paleoshoreline depths were compared to local sea-level curves to estimate ages, which suggest that some were reoccupied over multiple sea-level cycles. Additionally, previous studies determined conflicting uplift rates for the NCI, ranging from 0.16 to 1.5 m/ka. Our results suggest that a rate on the lower end of this range better fits the observed submerged paleoshorelines. Using the uplift rate of ~0.16 m/ka, we estimate that paleoshorelines formed during Marine Oxygen Isotope Stage 3, the LGM, and the Younger Dryas stade are preserved on the NCI platform. These results help clarify uplift rates for the NCI and illustrate the importance of sub-bottom data for mapping submerged paleoshorelines.
Impaired emotional and behavioural awareness and control in patients with dissociative seizures
Authors: Jungilligens Johannes , Wellmer Jörg , Schlegel Uwe , Kessler Henrik , Axmacher Nikolai , Popkirov Stoyan
Published: October 2019

Background

Dissociative seizures (DS) are brief episodes of disrupted awareness and behavioural control that may resemble epileptic seizures. They are thought to arise in the context of impaired emotion processing and disinhibition. In a multi-perspective neuropsychological study, we aim to assess specific metacognitive traits and behavioural features involved in the affective and cognitive underpinnings of DS (emotion recognition and regulation, inhibition, interoception and sense of agency).

Methods

Twenty prospectively recruited patients with video-EEG-confirmed DS and 20 healthy controls underwent comprehensive neuropsychological and psychiatric testing using validated questionnaires and structured interviews. Behavioural experimental data was obtained using a custom-made emotional go/no-go task, a digital Libet clock setup and a heartbeat counting paradigm.

Results

Emotion recognition, as quantified in the emotional go/no-go task, was impaired in the DS group, and correlated with alexithymic traits. Behavioural inhibition, especially under conditions that would require emotion regulation, was also reduced in the emotional go/no-go task compared to controls and was correlated with neuropsychometric measures of emotion regulation. Data from the Libet clock experiment suggested impaired behavioural awareness in DS patients. No evidence of impaired interoceptive awareness was found in the heartbeat counting task.

Conclusion

These results represent comprehensive experimental evidence for alterations in emotional and behavioural awareness and control in patients with DS that yield empirical evidence for current psychopathological models. Our findings offer a more detailed understanding of key pathogenic factors in DS and provide theoretical support for recently developed cognitive-behavioural therapies for DS.
LEARNING VOCABULARY THROUGH READING, LISTENING, AND VIEWING
Authors: Feng Yanxue , Webb Stuart
Published: October 2019

This study used a pretest-posttest-delayed posttest design at one-week intervals to determine the extent to which written, audio, and audiovisual L2 input contributed to incidental vocabulary learning. Seventy-six university students learning EFL in China were randomly assigned to four groups. Each group was presented with the input from the same television documentary in different modes: reading the printed transcript, listening to the documentary, viewing the documentary, and a nontreatment control condition. Checklist and multiple-choice tests were designed to measure knowledge of target words. The results showed that L2 incidental vocabulary learning occurred through reading, listening, and viewing, and that the gain was retained in all modes of input one week after encountering the input. However, no significant differences were found between the three modes on the posttests indicating that each mode of input yielded similar amounts of vocabulary gain and retention. A significant relationship was found between prior vocabulary knowledge and vocabulary learning, but not between frequency of occurrence and vocabulary learning. The study provides further support for the use of L2 television programs for language learning.
On Ramsey numbers of hedgehogs
Authors: Fox Jacob , Li Ray
Published: October 2019

The hedgehog Ht is a 3-uniform hypergraph on vertices $1, \ldots ,t + \left({\matrix{t \cr 2}}\right)$ such that, for any pair (i, j) with 1 ≤ i < j ≤ t, there exists a unique vertex k > t such that {i, j, k} is an edge. Conlon, Fox and Rödl proved that the two-colour Ramsey number of the hedgehog grows polynomially in the number of its vertices, while the four-colour Ramsey number grows exponentially in the square root of the number of vertices. They asked whether the two-colour Ramsey number of the hedgehog Ht is nearly linear in the number of its vertices. We answer this question affirmatively, proving that r(Ht) = O(t2 ln t).
International Organizations, Nongovernmental Organizations, and Police Implementation of Domestic Violence Policies in Liberia and Nicaragua
Authors: Medie Peace A. , Walsh Shannon Drysdale
Published: October 2019

Domestic violence is the predominant form of violence against women in most countries in Africa and Latin America. Scholars have theorized the adoption of domestic violence laws and policies in both regions. However, policy implementation is understudied and under theorized. Therefore, we compare how international organizations and women's nongovernmental organizations have influenced the implementation of domestic violence policies by police officers in Liberia and Nicaragua. We introduce the concept of the transnational implementation process and describe how international organizations and women's organizations have employed training, institutional and policy restructuring, and monitoring to influence police behavior at the street level. The effects of these strategies have been conditional on the political environment. We identify two patterns of international and domestic influence on street-level implementation: internationally led and domestically supported implementation in Liberia, with domestically led and internationally supported implementation in Nicaragua.
Award-Winning Photojournalism and Other News of the Week
Authors:   AGU
Published: October 2019

What Earth and space science stories are we recommending this week?
Increasing the Permeability of Hydrothermally Altered Andesite by Transitory Heating
Authors: Mordensky S. P. , Kennedy B. M. , Villeneuve M. C. , Lavallée Y. , Reichow M. K. , Wallace P. A. , Siratovich P. A. , Gravley D. M.
Published: October 2019

Changes in permeability can impact geological processes, geohazards, and geothermal energy production. In hydrothermal systems, high‐temperature heat sources drive fluid convection through the pore network of reservoir rocks. Additionally, thermal fluctuations may induce microfracturing and affect the mineralogical stability of the reservoir rock, thus modifying the fluid pathways and affecting permeability and strength. This study describes the results of thermal heating events lasting several hours on a “moderately altered” plagioclase‐clinochlore‐calcite‐quartz andesite and a “highly altered” plagioclase‐clinozoisite‐quartz‐clinochlore andesite from the Rotokawa Geothermal Field, New Zealand. We use a low thermal gradient (~1.2 °C/min) in an H2O‐saturated, 20‐MPa pressure environment to constrain changes in petrophysical properties associated with transitory thermal phenomena between 350 and 739 °C. As the treatment temperature increases, the mass reduces, while porosity and permeability increase. These effects were greater in the “moderately altered” andesite than in the “highly altered” andesite. Microfracturing is responsible for these changes at lower temperatures (e.g., ≤400 °C). At higher temperatures (e.g., >400 °C), microfracturing remains partially responsible for these rock property changes (e.g., higher permeability); however, these changes are also a product of clinochlore, quartz, and (when present) calcite reacting out of the altered andesite, and increasing porosity. We propose that at temperatures >400 °C, volumetric phase changes associated with heat‐driven reactions in a wet environment can contribute to microcracking and porosity/permeability changes. Our data support observations where high‐temperature conditions at the margins of magma bodies can be associated with substantial increased permeability and decreased strength.
Using Overshooting Top Area to Discriminate Potential for Large, Intense Tornadoes
Authors: Marion G. R. , Trapp R. J. , Nesbitt S. W.
Published: October 2019

Recent work established strong links between storm updraft width and the tornado intensity, suggesting that updraft width could be used to gauge potential tornado intensity. It was also posited that overshooting top area (OTA) could be used as an analog for updraft width and, thus, as a means to assess potential tornado intensity in observed storms. The implementation of new high‐resolution GOES‐R series satellites presents a unique opportunity to investigate these findings in severe weather observations. Herein, a method using GOES‐16 longwave infrared satellite data to quantify OTA of tornadic storms is explored. A comparison between observed tornado strength and OTA yields a strong correlation (R2 = 0.54). These results show the potential of these quantifications to be used with real‐time observations of tornadic storms, irrespective of storm mode, seasonality, or geographic location, allowing forecasters to determine which storms pose the highest risk to life and property.
How Robust is the Atmospheric Response to Projected Arctic Sea Ice Loss Across Climate Models?
Authors: Screen J. A. , Blackport R.
Published: October 2019

We assess the reliability of an indirect method of inferring the atmospheric response to projected Arctic sea ice loss from CMIP5 simulations, by comparing the response inferred from the indirect method to that explicitly simulated in sea ice perturbation experiments. We find that the indirect approach works well in winter, but has limited utility in the other seasons. We then apply a modified version of the indirect method to 11 CMIP5 models to reveal the robust and non‐robust aspects of the wintertime atmospheric response to projected Arctic sea ice loss. Despite limitations of the indirect method, we identify a robust enhancement of the Siberian High, weakening of the Icelandic Low, weakening of the westerly wind on the poleward flank of the eddy‐driven jet, strengthening of the subtropical jet, and weakening of the stratospheric polar vortex. The surface air temperature response to projected Arctic sea ice loss over mid‐latitude continents is non‐robust across the models.
Seasonal Variations and Global Wave Distributions in the Mars Thermosphere From MAVEN and Multisatellites Accelerometer‐Derived Mass Densities
Authors: Liu Jiandong , Jin Shuanggen , Li Yawen
Published: October 2019

Martian lower thermospheric variations are complex due to internal surface dust storms and external solar activities. However, limited Martian measurement data are restricted to observe and understand its variations in the past. In this paper, multisatellite accelerometer‐derived densities and the Mars Climate Database are used to investigate seasonal variations, gravity waves, and coupling effects with the internal and external inputs, including Mars Global Surveyor, Mars Reconnaissance Orbiter, Mars Odyssey, and Mars Atmosphere and Volatile EvolutioN Mission. The diurnal and seasonal structures are reconstructed by the data, and the phase of the cycles is formed by solar heating/ionizing processes. Both amplitude and phase are impacted by surface dust activities during autumn and winter, for which density increases about 1.5–3.5 times compared to spring and summer seasons. A parameterized model that includes a newly introduced dust index is proposed to well fit and reinterpret the seasonal cycles. Furthermore, the coupling process between internal atmospheric gravity waves (IAGWs) and dust activities are investigated and explained. During dust storm times/seasons, the IAGWs exhibit both narrower amplitude peaks and deposit their energy at higher altitudes relative to “clear sky” times. The IAGWs could extend their energies into higher layers beyond exobase due to a thermospheric layer expansion(i.e., density increase) during dust seasons.
An EOFs Study of Thermospheric Nitric Oxide Flux Based on TIEGCM simulations
Authors: Li Zheng , Knipp Delores , Wang Wenbin , Shi Yining , Wang Miao , Su Ye , Li Jingyuan
Published: October 2019

The National Center for Atmospheric Research Thermosphere‐Ionosphere‐Electrodynamics General Circulation Model (TIEGCM) is a three‐dimensional physics model of the Earth's upper atmosphere. Using eigen analysis, the hourly NO infrared radiative flux (NOF) during 2002–2015 obtained from TIEGCM simulations are decomposed into four empirical orthogonal functions (EOFs). The first mode of variability is significantly associated with Kp and F10.7, implying that geomagnetic activity and solar extreme ultraviolet flux make a strong contribution to NOF variability. EOF 2 shows an antisymmetry between the northern and southern hemispheres and has a very strong correlation with the solar declination angle, suggesting that annual and seasonal variations of thermospheric temperature and composition play dominant roles in EOF 2. Lacking a strong correlation with solar and/or geomagnetic indices, EOF 3 may be associated with thermospheric circulation driven by the offsets between the geomagnetic and geographic poles. A strong correlation with Dst indicates that EOF 4 may be associated with geomagnetic activity and NO transport due to the enhanced meridional wind. Additionally, comparisons between TIEGCM EOFs and Sounding of the Atmosphere using Broadband Emission Radiometry EOFs are also included in our study. This work shows important features of TIEGCM via eigen analysis on NOF and suggests some model shortcomings through the results of model‐data comparison.
Assessment of Water Cycle Intensification Over Land using a Multisource Global Gridded Precipitation DataSet
Authors: Markonis Y. , Papalexiou S. M. , Martinkova M. , Hanel M.
Published: October 2019

The change in the empirical distribution of future global precipitation is one of the major implications regarding the intensification of global water cycle. Heavier events are expected to occur more often, compensated by decline of light precipitation and/or number of wet days. Here, we scrutinize a new global, high‐resolution precipitation data set, namely, the Multi‐Source Weighted‐Ensemble Precipitation v2.0, to determine changes in the precipitation distribution over land during 1979–2016. To this end, the fluctuations of wet days precipitation quantiles on an annual basis and their interplay with annual totals and number of wet days were investigated. The results show increase in total precipitation, number of wet days, and heavy events over land, as suggested by the intensification hypothesis. However, the decline in light/medium precipitation or wet days was weaker than expected, debating the “compensation” mechanism.
Diurnal Variations of Dust During the 2018 Global Dust Storm Observed by the Mars Climate Sounder
Authors: Kleinböhl Armin , Spiga Aymeric , Kass David M. , Shirley James H. , Millour Ehouarn , Montabone Luca , Forget François
Published: October 2019

We report observations by the Mars Climate Sounder showing strong diurnal variations in temperature and the vertical dust distribution during the 2018 (Mars Year 34) global dust event. The temperature field shows weak diurnal tidal activity at equatorial latitudes but a strong diurnal tide in middle to high latitudes with a maximum amplitude of 29 K in the lower atmosphere of the south polar region. The diurnal variability of dust is small in the equatorial region and increases toward higher latitudes. At middle and low latitudes, comparable dust amounts are found about 5–10 km higher in the atmosphere on the dayside than on the nightside. The dust reaches the highest altitudes in the late afternoon and is found at the lowest altitudes in the late night. In the southern high latitudes a persistent cold air mass with low dust content is identified on the nightside of the planet centered at 3–6 a.m. local time. The observed variations are well represented by model simulations with the Laboratoire de Météorologie Dynamique General Circulation Model. Comparisons between data and model results suggest that the diurnal variations in the dust are largely driven by the meridional circulation exhibiting diurnal tidal variations. The model results show that the compact air mass in the south polar region has a high potential vorticity, supporting its interpretation as a remnant of the southern polar vortex, which is forced toward the nightside of the planet due to the enhanced diurnal tide during the global dust event.
Ecological memory and relocation decisions in fungal mycelial networks: responses to quantity and location of new resources
Authors: Fukasawa Yu , Savoury Melanie , Boddy Lynne
Published: October 2019

Saprotrophic cord-forming basidiomycetes, with their mycelial networks at the soil/litter interface on the forest floor, play a major role in wood decomposition and nutrient cycling/relocation. Many studies have investigated foraging behaviour of their mycelium, but there is little information on their intelligence. Here, we investigate the effects of relative size of inoculum wood and new wood resource (bait) on the decision of a mycelium to remain in, or migrate from, inoculum to bait using Phanerochaete velutina as a model. Experiments allowed mycelium to grow from an inoculum across the surface of a soil microcosm where it encountered a new wood bait. After colonisation of the bait, the original inoculum was moved to a tray of fresh soil to determine whether the fungus was still able to grow out. This also allowed us to test the mycelium’s memory of growth direction. When inocula were transferred to new soil, there was regrowth from 67% of the inocula, and a threshold bait size acted as a cue for the mycelium’s decision to migrate for a final time, rather than a threshold of relative size of inoculum: bait. There was greater regrowth from the side that originally faced the new bait, implying memory of growth direction.
DNA mechanotechnology reveals that integrin receptors apply pN forces in podosomes on fluid substrates
Authors: Glazier Roxanne , Brockman Joshua M. , Bartle Emily , Mattheyses Alexa L. , Destaing Olivier , Salaita Khalid
Published: October 2019

Podosomes are ubiquitous cellular structures important to diverse processes including cell invasion, migration, bone resorption, and immune surveillance. Structurally, podosomes consist of a protrusive actin core surrounded by adhesion proteins. Although podosome protrusion forces have been quantified, the magnitude, spatial distribution, and orientation of the opposing tensile forces remain poorly characterized. Here we use DNA nanotechnology to create probes that measure and manipulate podosome tensile forces with molecular piconewton (pN) resolution. Specifically, Molecular Tension-Fluorescence Lifetime Imaging Microscopy (MT-FLIM) produces maps of the cellular adhesive landscape, revealing ring-like tensile forces surrounding podosome cores. Photocleavable adhesion ligands, breakable DNA force probes, and pharmacological inhibition demonstrate local mechanical coupling between integrin tension and actin protrusion. Thus, podosomes use pN integrin forces to sense and respond to substrate mechanics. This work deepens our understanding of podosome mechanotransduction and contributes tools that are widely applicable for studying receptor mechanics at dynamic interfaces.
Acute hunger does not always undermine prosociality
Authors: Häusser Jan A. , Stahlecker Christina , Mojzisch Andreas , Leder Johannes , Van Lange Paul A. M. , Faber Nadira S.
Published: October 2019

It has been argued that, when they are acutely hungry, people act in self-protective ways by keeping resources to themselves rather than sharing them. In four studies, using experimental, quasi-experimental, and correlational designs (total N = 795), we examine the effects of acute hunger on prosociality in a wide variety of non-interdependent tasks (e.g. dictator game) and interdependent tasks (e.g. public goods games). While our procedures successfully increase subjective hunger and decrease blood glucose, we do not find significant effects of hunger on prosociality. This is true for both decisions incentivized with money and with food. Meta-analysis across all tasks reveals a very small effect of hunger on prosociality in non-interdependent tasks (d = 0.108), and a non-significant effect in interdependent tasks (d = −0.076). In study five (N = 197), we show that, in stark contrast to our empirical findings, people hold strong lay theories that hunger undermines prosociality.
NEXAFS imaging to characterize the physio-chemical composition of cuticle from African Flower Scarab Eudicella gralli
Authors: Baio Joe E. , Jaye Cherno , Sullivan Erin , Rasmussen Mette H. , Fischer Daniel A. , Gorb Stanislav , Weidner Tobias
Published: October 2019

The outermost surface of insect cuticle is a high-performance interface that provides wear protection, hydration, camouflage and sensing. The complex and inhomogeneous structure of insect cuticle imposes stringent requirements on approaches to elucidate its molecular structure and surface chemistry. Therefore, a molecular understanding and possible mimicry of the surface of insect cuticle has been a challenge. Conventional optical and electron microscopies as well as biochemical techniques provide information about morphology and chemistry but lack surface specificity. We here show that a near edge X-ray absorption fine structure microscope at the National Synchrotron Light Source can probe the surface chemistry of the curved and inhomogeneous cuticle of the African flower scarab. The analysis shows the distribution of organic and inorganic surface species while also hinting at the presence of aragonite at the dorsal protrusion region of the Eudicella gralli head, in line with its biological function.
The free energy landscape of retroviral integration
Authors: Vanderlinden Willem , Brouns Tine , Walker Philipp U. , Kolbeck Pauline J. , Milles Lukas F. , Ott Wolfgang , Nickels Philipp C. , Debyser Zeger , Lipfert Jan
Published: October 2019

Retroviral integration, the process of covalently inserting viral DNA into the host genome, is a point of no return in the replication cycle. Yet, strand transfer is intrinsically iso-energetic and it is not clear how efficient integration can be achieved. Here we investigate the dynamics of strand transfer and demonstrate that consecutive nucleoprotein intermediates interacting with a supercoiled target are increasingly stable, resulting in a net forward rate. Multivalent target interactions at discrete auxiliary interfaces render target capture irreversible, while allowing dynamic site selection. Active site binding is transient but rapidly results in strand transfer, which in turn rearranges and stabilizes the intasome in an allosteric manner. We find the resulting strand transfer complex to be mechanically stable and extremely long-lived, suggesting that a resolving agent is required in vivo.
Optical mapping of biological water in single live cells by stimulated Raman excited fluorescence microscopy
Authors: Shi Lixue , Hu Fanghao , Min Wei
Published: October 2019

Water is arguably the most common and yet least understood material on Earth. Indeed, the biophysical behavior of water in crowded intracellular milieu is a long-debated issue. Understanding of the spatial and compositional heterogeneity of water inside cells remains elusive, largely due to a lack of proper water-sensing tools with high sensitivity and spatial resolution. Recently, stimulated Raman excited fluorescence (SREF) microscopy was reported as the most sensitive vibrational imaging in the optical far field. Herein we develop SREF into a water-sensing tool by coupling it with vibrational solvatochromism. This technique allows us to directly visualize spatially-resolved distribution of water states inside single mammalian cells. Qualitatively, our result supports the concept of biological water and reveals intracellular water heterogeneity between nucleus and cytoplasm. Quantitatively, we unveil a compositional map of the water pool inside living cells. Hence we hope SREF will be a promising tool to study intracellular water and its relationship with cellular activities.
Towards symmetry driven and nature inspired UV filter design
Authors: Horbury Michael D. , Holt Emily L. , Mouterde Louis M. M. , Balaguer Patrick , Cebrián Juan , Blasco Laurent , Allais Florent , Stavros Vasilios G.
Published: October 2019

In plants, sinapate esters offer crucial protection from the deleterious effects of ultraviolet radiation exposure. These esters are a promising foundation for designing UV filters, particularly for the UVA region (400 – 315 nm), where adequate photoprotection is currently lacking. Whilst sinapate esters are highly photostable due to a cis-trans (and vice versa) photoisomerization, the cis-isomer can display increased genotoxicity; an alarming concern for current cinnamate ester-based human sunscreens. To eliminate this potentiality, here we synthesize a sinapate ester with equivalent cis- and trans-isomers. We investigate its photostability through innovative ultrafast spectroscopy on a skin mimic, thus modelling the as close to true environment of sunscreen formulas. These studies are complemented by assessing endocrine disruption activity and antioxidant potential. We contest, from our results, that symmetrically functionalized sinapate esters may show exceptional promise as nature-inspired UV filters in next generation sunscreen formulations.
Super-enhancer-guided mapping of regulatory networks controlling mouse trophoblast stem cells
Authors: Lee Bum-Kyu , Jang Yu jin , Kim Mijeong , LeBlanc Lucy , Rhee Catherine , Lee Jiwoon , Beck Samuel , Shen Wenwen , Kim Jonghwan
Published: October 2019

Trophectoderm (TE) lineage development is pivotal for proper implantation, placentation, and healthy pregnancy. However, only a few TE-specific transcription factors (TFs) have been systematically characterized, hindering our understanding of the process. To elucidate regulatory mechanisms underlying TE development, here we map super-enhancers (SEs) in trophoblast stem cells (TSCs) as a model. We find both prominent TE-specific master TFs (Cdx2, Gata3, and Tead4), and >150 TFs that had not been previously implicated in TE lineage, that are SE-associated. Mapping targets of 27 SE-predicted TFs reveals a highly intertwined transcriptional regulatory circuitry. Intriguingly, SE-predicted TFs show 4 distinct expression patterns with dynamic alterations of their targets during TSC differentiation. Furthermore, depletion of a subset of TFs results in dysregulation of the markers for specialized cell types in placenta, suggesting a role during TE differentiation. Collectively, we characterize an expanded TE-specific regulatory network, providing a framework for understanding TE lineage development and placentation.
Identification of atrial fibrillation associated genes and functional non-coding variants
Authors: van Ouwerkerk Antoinette F. , Bosada Fernanda M. , van Duijvenboden Karel , Hill Matthew C. , Montefiori Lindsey E. , Scholman Koen T. , Liu Jia , de Vries Antoine A. F. , Boukens Bastiaan J. , Ellinor Patrick T. , Goumans Marie José T. H. , Efimov Igor R. , Nobrega Marcelo A. , Barnett Phil , Martin James F. , Christoffels Vincent M.
Published: October 2019

Disease-associated genetic variants that lie in non-coding regions found by genome-wide association studies are thought to alter the functionality of transcription regulatory elements and target gene expression. To uncover causal genetic variants, variant regulatory elements and their target genes, here we cross-reference human transcriptomic, epigenomic and chromatin conformation datasets. Of 104 genetic variant regions associated with atrial fibrillation candidate target genes are prioritized. We optimize EMERGE enhancer prediction and use accessible chromatin profiles of human atrial cardiomyocytes to more accurately predict cardiac regulatory elements and identify hundreds of sub-threshold variants that co-localize with regulatory elements. Removal of mouse homologues of atrial fibrillation-associated regions in vivo uncovers a distal regulatory region involved in Gja1 (Cx43) expression. Our analyses provide a shortlist of genes likely affected by atrial fibrillation-associated variants and provide variant regulatory elements in each region that link genetic variation and target gene regulation, helping to focus future investigations.