bluuebunny/crossref_metadata_2025 huggingface dataset:
Risk Factors of Uterine Contraction After Ureteroscopy in Pregnant Women With Renal Colic
Authors: Li Chunjing , Li Jierong , Zhou Yanfen , Guo Mingjuan , Zhang Shilin , Liu Guoqing
Published: January 2021

Background: Ureteroscopy is widely applied in pregnant women with renal colic, but such patients are easy to experience uterine contraction after ureteroscopy, There are many factors which may result to uterine contraction, this study aims to explore the risk factors of uterine contraction triggered by ureteroscopy in pregnant women with renal colic. Methods: 101 pregnant women were retrospectively analyzed, all patients were hospitalized because of severe renal colic. All patients received ureteroscopy during which double J catheters were inserted into ureters for drainage. Patients received medical treatment individually according to their condition and the uterine contractions were detected by EHG within 12 hours after operation. Patients were classified as group A (uterine contraction, n=46) and group B (no uterine contraction, n=55) according to the presence or absence of continuously regular uterine contraction. Clinical characteristics were collected for further analysis, including history of deliveries, anesthesia methods, application of phloroglucinol or not, surgical time, Oxygen inhalation or not, pain relief or not after surgery, systemic inflammatory response syndrome(SIRS) occurred or not. A binary logistic regression analysis model was established to explore whether such clinical characteristics were relevant to uterine contraction after ureteroscopy. Results: The incidence of continuously regular uterine contraction occurred within 12 hours after ureteroscopy in pregnant women was 45.54%, and the presence of uterine contraction was related to the following factors(P<0.05): history of deliveries(primipara versus multipara)(OR=6.593, 95%CI 2.231-19.490), surgical time(each quarter additional)(OR=2.385, 95%CI 1.342-4.238), application of phloroglucinol(yes versus not)(OR=6.959, 95%CI 1.416-34.194), pain relief after surgery(yes versus not)(OR=6.707, 95%CI 1.978-22.738), SIRS occurred after surgery(yes versus not)(OR=0.099, 95%CI 0.014-0.713). Conclusion: Continuously regular uterine contraction is easy to occur within 12 hours after ureteroscopy in pregnant women. SIRS occurred after surgery is a risk factor for uterine contraction; on the contrary, no history of childbirth, shorter surgical time, application of phloroglucinol, pain relief after surgery are protective factors.
Evaluation of Anticoagulation Outcome among Patients Taking Warfarin: A Single-Center Experience, Northwest Ethiopia
Authors: Liyew Zelalem , tadesse abilo , Bekele Nebiyu , Tsegaye Tewodros
Published: January 2021

BackgroundWarfarin is a widely used oral anticoagulant in clinical practice. It is used to prevent arterial emboli in patients with atrial fibrillation, or prevent and treat venous thromboembolism. The efficacy and safety of warfarin depends on maintaining the INR within the therapeutic range. The proportion of time spent in the therapeutic INR range (TTR) is used to evaluate quality of anticoagulation control.MethodsA hospital-based cross sectional study was conducted between November 1, 2019 and October 31, 2020 at Cardiac and Hematology Clinic, University of Gondar hospital. A consecutive sampling method was used to recruit 338 study subjects. Proportion of time spent in the therapeutic range (TTR) was calculated using the Rosendaal’s linear interpolation method. TTR ≥65% was described as ‘optimal’ International Normalized Ratio (INR) control. The Data were entered into EPI Info version 4.4.1 and transported to SPSS version 20 for analysis. Logistic regression analysis was used to identify associated factors with optimal anticoagulation outcome (TTR ≥65%). P-values <0.05 were used to declare significant association.ResultA total of 338 study subjects were included in the study. The mean age of patients was 49 years. The majority of study participants attended formal education (79%) and were urban dwellers (57%). Atrial fibrillation was the commonest indication for warfarin therapy. One-third (33%) of study subjects achieved the desired INRs (INR=2.0-3.0), while about one-tenth (13%) of patients attained optimal INR control (TTR≥65%). There were no significant association of socio-demographic characteristics including age, gender, educational level and monthly income with optimal INR control (TTR ≥65%). Likewise, clinical characteristics including dose of warfarin, warfarin adherence, frequency of INR determination, other concomitant drug intake, co-existing comorbidities, consumption of green leafy vegetables and alcohol intake didn’t show significant association with optimal INR control (TTR≥65%).ConclusionInstitution-based validated protocol might be required to overcome the poor TTR level. ‘Anticoagulation (INR) clinic’ would be required to ‘scale-up’ INR control.
Association of HLA-DR Alleles With Pulmonary Cystic Fibrosis
Authors: asef alireza , Ghaffaripour Hossein Ali , Jamaati hamidreza , Varahram Mohammad , Adcock Ian , Mortaz Esmaeil
Published: January 2021

Background: Cystic fibrosis (CF) is the most common lethal autosomal recessive disease in white Caucasians. It affects many organs including the lung, pancreas, and liver. Whilst CF is a monogenic disease, several studies revealed a complex relationship between genotype and clinical phenotype of diseases. Objective of study: We examined the expression of HLA class II alleles among Iranian CF patients in relation to disease-related bacterial infection. Materials and methods: This study was conducted on 50 CF patients (27 males, 23 females aged 15.5±6.5 years) hospitalized in the Masih Daneshvari hospital in Tehran, Iran and 50 healthy age- and gender-matched control subjects. 5ml whole blood was harvested and after isolation of genomic DNA, HLA-DRB1 subtypes were determined by Single Specific Primer Polymerase Chain Reaction (SSP-PCR) methods. Results: HLA-DRB1*10 was less frequent than HLA-DRB1*04 and HLA-DRB1*11 but none reached significance. 16 CF patients with high serum IgE levels (430.25 ± 219.7 IU/ml) and 27 CF patients positive for Pseudomonas aeruginosa colonization were most closely associated with the HLA-DRB1*04 allele. 31 CF patients had candida Albicans colonization which was most closely associated with HLA-DRB1*11. 3 CF patients had allergic bronchopulmonary aspergillosis (ABPA) and two were diabetic. Discussion: The DR4 and DR11 serotypes that recognize the HLA-DRB1*04 and HLA-DRB1*11 gene products respectively, are not significantly enriched in the Iranian CF population. Further research should be conducted on DR4 and DR11 in CF patients to understand their possible role in infection and IgE expression.Trial registration: The study was approved by Ethical committee of Masih Daneshvari Hospital IR.SBMU.NRITLD.1395.234
Development of Species/Genus specific Primers for Identification of Three Trichoderma Species and for Detection of Trichoderma Genus
Authors: Zhou You , Wang Jun , Yang Laying , Guo Lijia , He Shuting , Zhou Wei , Huang Junsheng
Published: January 2021

Trichoderma is a widely used bio-control agent, and has excellent ability to antagonize plant pathogens and promoting plant growth. It has been successfully used to control various plant diseases. The premise of using Trichoderma is accurate identification of it. In this study, four sets of species/genus-specific primers were designed based on the translation elongation factor 1-alpha (tef1) gene and internal transcribed spacer (ITS) region, in order to identify Trichoderma harzianum, T. koningiopsis, and T.virens, and detect the genus of Trichoderma. Here, the rapid, simple, and reliable PCR methods were development using the species-specific primers EHarF2/EHarR2, EKoisF/EKoisR, and EVireF/EVireR to produce 253 bp (tef1 gene), 255 bp (tef1 gene), and 263 bp (tef1 gene) DNA bands to identify T. harzianum, T. koningiopsis, and T. virens, respectively. The genus-specific primers ITricF/ITricR produces a single DNA band in the range of 103–113 bp (ITS region) to distinguish Trichoderma from other genera fungi, and the size of the band is related to the species of Trichoderma. In addition, ITricF/ITricR could use for real-time PCR amplification for detection the quantity of Trichoderma spp..
Sliding Mode Variable Impedance Control for 4RRR Redundantly Actuated Parallel Robot
Authors: Fan Ya-Nan , He Guang-Ping , Liang Xu , Su Ting-Ting , Zhang Jie
Published: January 2021

The workspace of parallel robot is limited, and the distribution characteristics of kinematics and force maneuverability are complex in the workspace. In addition, there are often operational singularities. The redundant actuation technology can not only overcome singularity problem of force maneuverability of parallel mechanism, but also eliminate the clearance of the mechanism, dynamically adjust the operating stiffness, realize the optimized operation of energy consumption, etc. In this paper, with the goal of realizing dexterous dynamic output control, the variable impedance control technology of redundantly actuated parallel robot based on operation space is studied. Compared with the traditional invariable impedance control, the variable impedance control can adapt to the change of unknown environment by time-varying controlling parameters, which provides the possibility to realize the polishing of complex curved surfaces and thin-walled parts, assembly task and improves the performance of the system and the machining quality of the parts. In order to avoid the influence of unmodeled errors and external interferences on the system, based on the sliding mode control (SMC) strategy, the variable impedance control (VIC) in the operating space of 4RRR redundantly actuated parallel robot (4RAPR) is proposed. The robust stability of the closed-loop system is analyzed and verified by Matlab programming simulation.
Introduction
Authors: Ronzoni Miriam
Published: January 2021

Megaregional Trade Agreements: Challenges to Distributive Justice and Self-Determination?
Fair Trade: An Imperfect Obligation?
Authors: Hassoun Nicole
Published: January 2021

Fair Trade is under fire. Some critics argue, for instance, that there is no obligation to purchase Fair Trade certified products and that doing so may even be counter-productive. Others worry that well-justified conceptions of what makes trade fair can conflict. Yet others suggest that the common arguments for Fair Trade cannot justify purchasing Fair Trade certified goods, in particular. This paper starts by sketching one common argument for Fair Trade and defends it against this last line of criticism. In particular, it argues that we should purchase Fair Trade certified goods because doing so benefits the poor even though there are other ways to alleviate poverty. It then considers how other common arguments for Fair Trade fare in light of similar criticism and concludes that they may well succeed.
Refugees and responsibilities of justice
Authors: Owen David
Published: January 2021

This essay develops, within the terms of the recent New York Declaration, an account of the shared responsibility of states to refugees and of how the character of that responsibility effects the ways in which it can be fairly shared. However, it also moves beyond the question of the general obligations that states owe to refugees to consider ways in which refugee choices and refugee voice can be given appropriate standing with the global governance of refuge. It offers an argument for the normative significance of refugee’s reasons for choosing states of asylum and linked this to consideration of a refugee matching system and to refugee quota trading conceived as responsibility-trading, before turning to the issue of the inclusion of refugee voice in relation to the justification of the norms of refugee governance and in relation to the institutions and practices of refugee governance through which those norms are given practical expression.
Refusing and Resisting Borders
Authors: Sagar Alex
Published: January 2021

N/A
EU immigration, Welfare Rights and Populism: A Normative Appraisal of Welfare Populism
Authors: Efthymiou Dimitrios E.
Published: January 2021

Populists in the EU often call for restrictions on EU immigrants’ access to welfare rights. These calls are often demagogic and parochial. This paper aims to show what exactly is both distinct and problematic with these populist calls from a normative point of view while not necessarily reducible to demagogy and parochialism. The overall aim of the paper is not to argue that all populists call for such restrictions nor to claim that all calls for such restrictions are populist. The purpose of the paper is rather humble. It only aims to show that populist calls for restrictions on EU immigrants’ access to welfare rights are characterised by two normatively problematic arguments that target two different subsets of the citizenry: what I dub for the purpose of this paper the moralists and the immoralists. It is the way populists address these two subsets of the citizenry, as well as the fact that they could simultaneously appeal to the concerns of both groups, that makes populist approaches to welfare rights both conceptually distinct to other approaches as well as potentially politically appealing to a more diverse population of voters.
Transnational Populism, Democracy, and Representation: Pitfalls and Potentialities
Authors: Kuyper Jonathan , Moffitt Benjamin
Published: January 2021

Current work on populism stresses its relationship to nationalism. However, populists increasingly make claims to represent ‘the people’ across beyond national borders. This advent of ‘transnational populism’ has implications for work on cosmopolitan democracy and global justice. In this paper, we advance and substantiate three claims. First, we stress populism’s performative and claimmaking nature. Second, we argue that transnational populism is both theoretically possible and empirically evident in the contemporary global political landscape. Finally, we link these points to debates on democracy beyond the state. We argue that, due to the a) performative nature of populism, b) complex interdependencies of peoples, and c) need for populists to gain and maintain support, individuals in one state will potentially have their preferences, interests, and wants altered by transnational populists’ representative claims. We unpack what is normatively problematic in terms of democratic legitimacy about this and discuss institutional and non-institutional remedies.
Populism, Cosmopolitanism, or Democratic Realism?
Authors: Meckstroth Christopher
Published: January 2021

This article argues that populism, cosmopolitanism, and calls for global justice should be understood not as theoretical positions but as appeals to different segments of democratic electorates with the aim of assembling winning political coalitions. This view is called democratic realism: it considers political competition in democracies from a perspective that is realist in the sense that it focuses not first on the content of competing political claims but on the relationships among different components of the coalitions they work to mobilise in the pursuit of power. It is argued that Laclau’s populist theory offers a sort of realist critique of other populists, but that his view neglects the crucial dynamics of political coalition-building. When the relation of populism to global justice is rethought from this democratic realist angle, one can better understand the sorts of challenges each faces, and also where and how they come into conflict.
International Injustice: Past and Present
Authors: Banai Ayelet
Published: January 2021

Review: Daniel Butt, ‘Rectifying International Injustice: Principles of Compensation and Restitution Between Nations, Oxford University Press, 2009.
Do Affluent Countries Violate the Human Rights of the Global Poor?
Authors: Montero Julio
Published: January 2021

In this article I consider Thomas Pogge’s thesis that affluent countries are violating the human rights of the global poor by contributing support to the current global institutional order. My claim is that affluent countries are not violating the human rights of the global poor in the ways suggested by Pogge. I start by defining a set of conditions that ought to obtain in order to say that a human rights violation has taken place. Then I consider two possible interpretations of Pogge’s thesis and argue that none of them fulfills the conditions required to speak of a human rights violation. On my view, as long as domestic states have the capacity to fulfill the human rights of their own people, poverty constitutes a domestic human rights violation even if the international institutional order somehow contributes to creating this state of affairs. Finally, I examine what transnational duties human rights entail and claim that affluent countries must contribute to the creation of an international order providing domestic states accurate background conditions for the promotion of human rights at the domestic level.
Global Protection of the Right to Asylum and Partial Compliance
Authors: Kuosmanen Jaakko
Published: January 2021

The paper examines obligations towards bearers of the right to asylum in circumstances of partial compliance. Who should bear the burdens when a state responsible for assisting bearers of the right to asylum fails to comply with the requirements of justice and unjustly defaults on its responsibilities? Are the complying states obligated to ‘take up the slack’ and assist the bearers of the right to asylum, or are they obligated to bear only their ‘fair share’ of burdens in the global protection of the right to asylum. The paper argues that the complying states with the capacity to assist can have an obligation of justice to assist bearers of the right to asylum when other states unjustly default on their responsibilities.
Can Dangerous Climate Change Be Avoided?
Authors: Moellendorf Darrel
Published: January 2021

This article discusses obstacles to overcoming dangerous climate change. It employs an account of dangerous climate change that takes climate change and climate change policy as dangerous if it imposes avoidable costs of poverty prolongation. It then examines plausible accounts of the collective action problems that seem to explain the lack of ambition to mitigate. After criticizing the merits of two proposals to overcome these problems, it discusses the pledge and review process. It argues that pledge and review possesses the virtues of encouraging broad participation and of providing a procedural safeguard for the right of sustainable development. However, given the perceptions of the marginal short term costs of mitigation, pledge and review is unlikely, at least initially, to issue in an agreement to make deep reductions in greenhouse gas emissions. Because there is no rival approach that seems likely to better instantiate the two virtues, pledge and review may be the best available policy for mitigation. Moreover, recent economic research suggests that the co-benefits of mitigation may be greater than previously assumed and that the costs of renewable energy may be less than previously calculated. This would radically undermine claims that the short term mitigation costs necessarily render mitigation irrational and produce collective action problems. Given the circumstances, pledge and review might be our best hope to avoid dangerous climate change.
Imperialism, Globalization and Resistance
Authors: Vrousalis Nicholas
Published: January 2021

Imperialism is the domination of one state by another. This paper sketches a nonrepublican account of domination that buttresses this definition of imperialism. It then defends the following claims. First, there is a useful and defensible distinction between colonial and liberal imperialism, which maps on to a distinction between what I will call coercive and liberal domination. Second, the main institutions of contemporary globalization, such as the WTO, the IMF, the World Bank, etc., are largely the instruments of liberal imperialism; they are a reincarnation of what Karl Kautsky once called ‘ultraimperialism’. Third, resistance to imperialism can no longer be founded on a fundamental right to national self-determination. Such a right is conditional upon and derivative of a more general right to resist domination.
Global Structural Exploitation: Towards an Intersectional Definition
Authors: McKeown Maeve
Published: January 2021

If Third World women form ‘the bedrock of a certain kind of global exploitation of labour,’ as Chandra Mohanty argues, how can our theoretical definitions of exploitation account for this? This paper argues that liberal theories of exploitation are insufficiently structural and that Marxian accounts are structural but are insufficiently intersectional. What we need is a structural and intersectional definition of exploitation in order to correctly identify global structural exploitation. Drawing on feminist, critical race/post-colonial and post-Fordist critiques of the Marxist definition and the intersectional accounts of Maria Mies and Iris Marion Young, this paper offers the following definition of structural exploitation: structural exploitation refers to the forced transfer of the productive powers of groups positioned as socially inferior to the advantage of groups positioned as socially superior. Global structural exploitation is a form of global injustice because it is a form of oppression.
Raman spectroscopic quantification of tetrahedral boron in synthetic aluminum-rich tourmaline
Authors: Kutzschbach Martin , Wunder Bernd , Wannhoff Iris , Wilke Franziska D.H. , Couffignal Frédéric , Rocholl Alexander
Published: January 2021

The Raman spectra of five [4]B-bearing tourmalines of different composition synthesized at 700 °C/4.0 GPa (including first-time synthesis of Na-Li-[4]B-tourmaline, Ca-Li-[4]B-tourmaline, and Ca-bearing ☐-[4]B-tourmaline) reveal a strong correlation between the tetrahedral boron content and the summed relative intensity of all OH-stretching bands between 3300–3430 cm–1. The band shift to low wavenumbers is explained by strong O3-H···O5 hydrogen bridge bonding. Applying the regression equation to natural [4]B-bearing tourmaline from the Koralpe (Austria) reproduces the EMPA-derived value perfectly [EMPA: 0.67(12) [4]B pfu vs. Raman: 0.66(13) [4]B pfu]. This demonstrates that Raman spectroscopy provides a fast and easy-to-use tool for the quantification of tetrahedral boron in tourma-line. The knowledge of the amount of tetrahedral boron in tourmaline has important implications for the better understanding and modeling of B-isotope fractionation between tourmaline and fluid/melt, widely used as a tracer of mass transfer processes.
Genetic diversity among 435 barley accessions based in morpho-agronomical characteristics under irrigation in the Brazilian savannah
Authors: Monteiro Vitor Antunes , Amabile Renato Fernando , Spehar Carlos Roberto , Faleiro Fábio Gelape , Vieira Eduardo Alano , Peixoto José Ricardo , Junior Walter Quadros Ribeiro , Montalvão Ana Paula Leite
Published: January 2021

The success of barley (Hordeum vulgare L.) cultivation and its adaptation to cropping systems relies on the knowledge and utilization of existing variability in germplasm banks. The objective of this work was to analyse diversity among pre-selected barley accessions to organize a working collection and to identify genotypes for a breeding program for irrigated barley in the Brazilian Savannah. The field experiment was conducted under irrigation in Planaltina, DF, Brazil. The plant population consisted of 433 accessions plus BRS 180 and BRS 195 as checks. The accessions were evaluated using fifteen morpho agronomic descriptors, in which 11 quantitative and four discrete. The interpolated control design was used for the statistical analysis. A genetic distance matrix was calculated using Gower’s coefficient. From the matrix, a grouping analysis was conducted, using the optimizing Tocher method and the graphic dispersion distance. The genetic distances varied between 0.025 and 0.572, with a mean of 0.256. The accessions were distributed in 18 groups by the Tocher method, which was directly related to the graphic dispersion. The existing genetic divergence in the collection under study helped the definition of accessions in crossing blocks from breeding programs directed to the savannah environment.
Morphophysiology of ornamental sunflower plant irrigated with saline water and application of silicon
Authors: Alves Lunara de Sousa , Véras Mário Leno Martins , Sousa Nelto Almeida de , Araújo Fernanda Ferreira de , Melo Edinete Nunes de , Abrantes Ewerton Gonçalves de , Dantas Adriana Pricilla Jales , Dias Thiago Jardelino , Bezerra Ana Carolina , Leal Márcia Paloma da Silva
Published: January 2021

The use of saline water in agriculture is an alternative, especially in regions with water scarcity, such as the Brazilian Northeast semiarid. However, salt stress considerably reduces plant growth and development. In this sense, the objective was to evaluate the morphophysiological responses of the ornamental sunflower irrigated with saline water under application of silicon. The experimental design was entirely randomized conducted in a factorial 4 x 5 with 6 replicates, related to four electrical conductivity of the irrigation water (ECw): 0.5; 1.5; 2.5 and 3.5 dS m-1 five silicon rates: 0, 50, 100, 150 and 200 mg L-1, proceeding to the evaluation of: plant height, stem diameter, number of leaves, absolute and relative growth rates, initial fluorescence, maximum fluorescence, variable fluorescence, maximum efficiency of the photochemical process in FSII, potential quantum yield of photosystem II, stomatal conductance and instant efficiency in the use of water. The gradual increase of ECw reduces growth, chlorophyll fluorescence a and stomatal opening of the ornamental sunflower plants. The application of silicon above 100 mg L-1 promotes a decrease in ornamental sunflower stomatal conductance. It is recommended to irrigate ornamental sunflower plants with water of 0.5 dS m-1 associated with the application of 100 mg L-1 of silicon.
Do Islamic Bank Assets Help Reducing Poverty? The Correlation Assessment in Poverty Cluster
Authors: Muflih Muhammad
Published: January 2021

Abstract: The purpose of this research is to examine the ability of total assets, deposit funds, and financing of Islamic banks in alleviating poverty in each province. Provincial clusters were measured by poverty levels which are deliberately established to reveal the level of success of each provincial cluster in reducing poverty. This study incorporates methods of hierarchical cluster and non-parametric correlation as means of exposing characters of the relationship between Islamic bank assets and poverty in each cluster measured by low, moderate, and high poverty levels. To refine the findings, correlation tests are performed on each cluster. This study proves that total assets, deposit funds, and Islamic bank financing have a significant negative relationship with poverty in clusters with high poverty level. On the other hand, in clusters with moderate and low poverty levels, the three variables do not have significant negative relationship with poverty. The finding implies the importance of Islamic banks to map the poverty weights in each group of regions so that it can be used to improve the level of poverty alleviation success.Abstrak: Penelitian ini bertujuan untuk menguji kemampuan total aset, dana pihak ketiga, dan pembiayaan bank syariah mengentaskan kemiskinan di setiap provinsi. Kluster provinsi yang diukur menurut tingkat kemiskinan untuk mengungkap level keberhasilan setiap kelompok dalam mengurangi angka kemiskinan. Penelitian ini memadukan metode kluster hirarki dan korelasi non-parametrik sebagai alat untuk mengungkap karakter hubungan aset-aset bank syariah dan kemiskinan. Untuk mempertajam temuan, uji korelasi dilakukan terhadap masing-masing kluster. Penelitian ini membuktikan bahwa total aset, dana pihak ketiga, dan pembiayaan bank syariah memiliki hubungan negatif signifikan dengan kemiskinan pada kluster yang tingkat kemiskinannya tinggi. Sedangkan pada kluster yang tingkat kemiskinannya sedang dan rendah, ketiga variabel tersebut tidak memiliki hubungan negatif signifikan dengan kemiskinan. Temuan ini mengimplikasikan pentingnya bank syariah memetakan bobot kemiskinan di setiap kelompok daerah sehingga dapat digunakan untuk meningkatkan level keberhasilan pengentasan kemiskinan.
Challenges of Islamic Supervisory in The Islamic Financial Technology Industry
Authors: Muhammad Rifqi , Lanaula Rima
Published: January 2021

Abstract: Islamic financial industry is increasingly developing with the presence of financial technology both in the form of peer to peer lending and crowdfunding. Islamic financial technology (fintech) enables sharia business players to formulate financing schemes using innovative and diverse sharia contracts. This has become a challenge in the aspect of sharia supervision due to limited regulations, corporate governance, and human resource capabilities. This paper will discuss the development of the financial technology industry in Indonesia and specifically the development of Islamic financial technology in terms of the growth in the number of service providers, the amount of financing, regulation and corporate governance. Secondly, this paper will discuss the challenges faced in the field of sharia compliance and the role of the sharia supervisory board in sharia supervision. Third, this paper will formulate corporate governance and human resource competencies of sharia supervisory board to encourage sharia compliance. Finally, this paper will formulate the conclusions and recommendations for improving regulation of the financial technology industry.Abstrak: Industri keuangan syariah semakin diramaikan dengan munculnya teknologi finansial (financial technology) baik yang berbentuk peer to peer lending maupun crowdfunding. Islamic financial technology (fintech) memungkinkan para pelaku bisnis syariah untuk merumuskan skema pembiayaan menggunakan akad-akad syariah yang semakin inovatif dan beragam. Hal ini menjadi tantangan dalam aspek pengawasan syariah karena keterbatasan regulasi, tata kelola perusahaan (corporate governance), dan kemampuan sumber daya manusia. Paper ini akan membahas perkembangan industri teknologi finansial di Indonesia dan secara khusus perkembangan Islamic financial technology dari sisi pertumbuhan jumlah penyedia jasa, jumlah pembiayaan, regulasi maupun tata kelola perusahaan. Kedua, paper ini membahas tantangan yang dihadapi dalam bidang kepatuhan syariah dan peran DPS (Dewan Pengawas Syariah) dalam pengawasan syariah. Ketiga, paper ini merumuskan tata kelola perusahaan dan kompetensi sumber daya manusia DPS untuk mendorong kepatuhan syariah Islamic financial technology. Akhirnya, paper ini merumuskan kesimpulan dan rekomendasi untuk perbaikan regulasi industri teknologi finansial.
Histone Demethylase KDM4A Inhibition Represses Neuroinflammation and Improves Functional Recovery in Ischemic Stroke
Authors: Liu Yanfei , Zhao Liang , Zhang Jianzhong , Lv Liquan , Han Kaiwei , Huang Chengguang , Xu Zheng
Published: January 2021

Background:

Epigenetic regulation concerning histone lysine methylation and demethylation play a
crucial role in cerebral ischemic injury. Dysregulation of histone methylation modifiers has been identified in
cerebral ischemia. However, the function and the underlying mechanisms of histone demethylase KDM4A on
neuroinflammation and functional recovery in ischemic stroke remains unclear.

Methods:

In the present study, the rat model of transient middle cerebral artery occlusion (MCAO) was established,
and the expression level of KDM4A was assessed in brain tissues. KDM4A inhibition was carried out
by intrathecal injection with Lv-shKDM4A, and then pro-inflammatory cytokines and neurological functional
tests were assessed.

Results:

We demonstrated that rats subjected to MCAO showed a markedly increased expression of KDM4A,
pro-inflammatory cytokines IL-1β and TNF-α, and vascular endothelial growth factor (VEGF), whereas KDM4A
inhibition repressed the expression of IL-1β, TNF-α and VEGF both in MCAO and oxygen-glucose deprivation
(OGD) models. Furthermore, KDM4A inhibition showed a marked improvement in spatial learning and
sensorimotor function, as suggested by mNSS and foot-fault test, respectively. Mechanistically, KDM4A inhibition
repressed NF-κB signaling activation in microglia as indicated by decreased expression and nuclear translocation
of p65 in vitro and in vivo. The effects of KDM4A overexpression on exacerbating neuroinflammation
was inhibited by additional treatment of NF-κB inhibitor (JSH-23).

Conclusion::

The current results demonstrated KDM4A inhibition improves functional recovery in ischemic
stroke by repressing NF-κB activation and subsequent neuroinflammation.
Applications of ROS-InducedZr-MOFs Platform in Multimodal Synergistic Therapy
Authors: Ding Qiongjie , Liu Yiwei , Shi Chuncheng , Xiao Jifei , Dai Wei , Liu Dong , Chen Haoyuan , Li Baohong , Liu Jianqiang
Published: January 2021

Background:

Metal-organic frameworks (MOFs) possess adjustable aperture, high load
capacities, tailorable structures, and excellent biocompatibilities for their use as drug delivery carries
in cancer therapy. Until now, Zr-MOFs, in particular, combine optimal stability towards hydrolysis
and post synthetic modification with low toxicity, and are widely studied for their excellentbiological
performance.

Introduction:

This review comprises the exploration of Zr-MOFs as drug delivery devices (DDSs)
with a focus on various new methods, including chemotherapy (CT), photodynamic therapy (PDT),
photothermal therapy (PTT), sonodynamic therapy (SDT), radiotherapy, immunotherapy, gene therapy
and related combined therapies, which all generate reactive oxygen species (ROS) to achieve high
efficiency of tumor therapy.

Conclusion:

We described and summarized these pertinent examples of the therapeutic mechanisms
and highlighted the antitumor effects of their biological application both in vitro and in vivo. The perspectives
on their future applications and the analogous challenge of the Zr-MOFs materials are given.
Systematic Analysis and Review of Magnetic Resonance Imaging (MRI) Reconstruction Techniques
Authors: Kumar Penta Anil , Gunasundari Ramalingam , Aarthi Ramalingam
Published: January 2021

Background:

Magnetic Resonance Imaging (MRI) plays an important role in the field
of medical diagnostic imaging as it poses non-invasive acquisition and high soft-tissue contrast.
However, a huge time is needed for the MRI scanning process that results in motion artifacts, degrades
image quality, misinterprets the data, and may cause discomfort to the patient. Thus, the
main goal of MRI research is to accelerate data acquisition processing without affecting the quality
of the image.

Introduction:

This paper presents a survey based on distinct conventional MRI reconstruction
methodologies. In addition, a novel MRI reconstruction strategy is proposed based on weighted
Compressive Sensing (CS), Penalty-aided minimization function, and Meta-heuristic optimization
technique.

Methods:

An illustrative analysis is done concerning adapted methods, datasets used, execution tools, performance
measures, and values of evaluation metrics. Moreover, the issues of existing methods and the research gaps considering
conventional MRI reconstruction schemes are elaborated to obtain improved contribution for devising significant MRI
reconstruction techniques.

Results:

The proposed method will reduce conventional aliasing artifact problems, may attain lower
Mean Square Error (MSE), higher Peak Signal-to-Noise Ratio (PSNR), and Structural SIMilarity
(SSIM) index.

Conclusion:

The issues of existing methods and the research gaps considering conventional MRI
reconstruction schemes are elaborated to devising an improved significant MRI reconstruction technique.
THE EFFECT OF TEAM WORK, LEADERSHIP STYLE, AND ORGANIZATIONAL CULTURE ON NURSE PERFORMANCE WITH ORGANIZATIONAL COMMITMENTS AS MEDIATION VARIABLES IN HOSPITAL TYPE B IN JAKARTA
Authors: Wahyuningsih Sri Ari , Thoyib Armanu , - Rofiaty , Sabil Ananda
Published: January 2021

ABSTRACT This study aims to analyze the influence of team work, leadership style and organizational culture on nurse performance with organizational commitment as a mediating variable. The research unit is nurses at Type B hospitals in Jakarta. The population is 1362 nurses. Methods of collecting data using surveys. The research instrument used a questionnaire. Questionnaires were distributed to 523 respondents. Data analysis method uses Structural Equation Modeling-Partial Least Square SEM-PLS). The results of the study prove that teamwork has a positive effect on nurse performance. Teamwork does not affect organizational commitment. Organizational culture has a positive effect on nurse performance. Organizational culture has a positive effect on organizational commitment. Leadership style does not affect nurse performance. Leadership style does not affect organizational commitment. Organizational commitment has a positive effect on nurse performance. Organizational commitment cannot play a role in mediating the influence of teamwork on nurse performance. Organizational commitment can play a role in mediating the influence of organizational culture on nurse performance. Organizational commitment cannot play a role in mediating the influence of leadership style on nurse performance.Â  Keywords: Teamwork, Organizational Culture, Leadership Style, Organizational Commitment, Nurse Performance.
THE IMPACT OF ENTREPRENEURSHIP EDUCATION TO ENTREPRENEUR INTENTION THROUGH PLANNED BEHAVIOUR AS INTERVENING VARIABLE (Study in Brawijaya University Students Have Partcipation the Entrepreneurship Education for 2016 study programs)
Authors: Baihaqi Aufa Izzuddin , Arifin Zainul , Mawardi M. Kholid
Published: January 2021

Although many researchers have focused on entrepreneurship education, little research has been done into the effects for students and the overall effectiveness of the university for entrepreneurship education programs in Indonesia. The research focused using theory of planned behavior and investigates the impact of entrepreneurship programs on the entrepreneur intention students in Brawijaya University. Data for this study is drawn from 9 faculty in Brawijaya University. Sample used in this research have 382 student 2016 period. The results show that participants of entrepreneurship education programs in brawijaya university have a positive effect on atitude toward entrepreneurship, subjective norm and perceived behavioral control. Variable atitude toward entrepreneurship, subjective norm and perceived behavioral control have a positive effect to entrepreneurial intention. Furthermore, the findings of this report entrepreneurship education to entrepreneur intention have a positive effect and significant through planned behaviour as intevening variable in Brawijaya University student 2016 period
FACTORS AFFECTING VOLUNTARY DISCLOSURE WITH CORPORATE GOVERNANCE AS MODERATING VARIABLES
Authors: Widayawati Eny , Dzulkirom Moch , Darmawan Ari
Published: January 2021

ABSTRACTPurpose â€” The purpose of this research is to analyze and prove the influence of independent variables that are proxied by profitability, liquidity, firm size on voluntary disclosure, and moderated by corporate governance variables.Design/methodology/approach â€” The object of the research is the companies listed on the IDX from 2012 through 2016. This research uses a purposive sampling method involving 45 annual company reports and uses multiple regression and MRA (Moderated Regression Analysis) as a data analysis tool.Findings â€” The results of this research indicate that there is a significant positive effect between liquidity, firm size on voluntary disclosure, there is a significant negative effect between profitability and voluntary disclosure, and corporate governance moderates the relationship between profitability, liquidity, firm size, and voluntary disclosure.Practical Implications â€”Â  Companies with high liquidity supported by good corporate governance will reduce voluntary disclosures due to the existence of independent commissioners whose positions are still less influential with the board of commissioners and board of directors, in the other hand, companies with low profitability supported by good corporate governance encourage managers to disclose company information more broadly to convince all stakeholders concerned.Originality/value â€” Keywords Profitability, Liquidity, Company size, Corporate governance, Voluntary disclosure.Paper Type Research Paper (secondary data)
THE EFFECT OF WORK ETHOS ON PERFORMANCE OF EMPLOYEES IN THE OFFICE OF CULTURE AND TOURISM OF JAYAWIJAYA REGENCY
Authors: Haryati Tati , Ismail Rudihartono
Published: January 2021

ABSTRACTPurpose â€” The purpose of this research is to determine whether there is an effect of the work ethic on the Performance of Employees of the Culture and Tourism Office of Jayawijaya Regency.Design/methodology/approach â€” The researchers use quantitative research methods with associative to determine the effect of work ethic on employee performance at the Office of Culture and Tourism of Jayawijaya Regency. This research uses library research instruments, observation, documentation, and questionnaires with a Likert Scale.Findings â€” Results revealed a positive and significant influence between the assessment of Work Ethics and Employee Performance at the Office of Culture and Tourism of Jayawijaya Regency.Practical Implications â€” The success of an employee's performance can be determined if an agency has a work evaluation system. So an employee must follow the rules and instructions so that later it can be in accordance with the goals of the previous agency.Originality/value â€” Keywords Work Ethic, Performance, EmployeesPaper Type Research Paper (case study)
Examining the Correlation Between Depression and Social Behavior on Smartphones Through Usage Metadata: Empirical Study
Authors: Wang Yameng , Ren Xiaotong , Liu Xiaoqian , Zhu Tingshao
Published: January 2021

Background

As smartphone has been widely used, understanding how depression correlates with social behavior on smartphones can be beneficial for early diagnosis of depression. An enormous amount of research relied on self-report questionnaires, which is not objective. Only recently the increased availability of rich data about human behavior in digital space has provided new perspectives for the investigation of individual differences.

Objective

The objective of this study was to explore depressed Chinese individuals’ social behavior in digital space through metadata collected via smartphones.

Methods

A total of 120 participants were recruited to carry a smartphone with a metadata collection app (MobileSens). At the end of metadata collection, they were instructed to complete the Center for Epidemiological Studies-Depression Scale (CES-D). We then separated participants into nondepressed and depressed groups based on their scores on CES-D. From the metadata of smartphone usage, we extracted 44 features, including traditional social behaviors such as making calls and sending SMS text messages, and the usage of social apps (eg, WeChat and Sina Weibo, 2 popular social apps in China). The 2-way ANOVA (nondepressed vs depressed × male vs female) and multiple logistic regression analysis were conducted to investigate differences in social behaviors on smartphones among users.

Results

The results found depressed users received less calls from contacts (all day: F1,116=3.995, P=.048, η2=0.033; afternoon: F1,116=5.278, P=.02, η2=0.044), and used social apps more frequently (all day: F1,116=6.801, P=.01, η2=0.055; evening: F1,116=6.902, P=.01, η2=0.056) than nondepressed ones. In the depressed group, females used Weibo more frequently than males (all day: F1,116=11.744, P=.001, η2=0.092; morning: F1,116=9.105, P=.003, η2=0.073; afternoon: F1,116=14.224, P<.001, η2=0.109; evening: F1,116=9.052, P=.003, η2=0.072). Moreover, usage of social apps in the evening emerged as a predictor of depressive symptoms for all participants (odds ratio [OR] 1.007, 95% CI 1.001-1.013; P=.02) and male (OR 1.013, 95% CI 1.003-1.022; P=.01), and usage of Weibo in the morning emerged as a predictor for female (OR 1.183, 95% CI 1.015-1.378; P=.03).

Conclusions

This paper finds that there exists a certain correlation between depression and social behavior on smartphones. The result may be useful to improve social interaction for depressed individuals in the daily lives and may be insightful for early diagnosis of depression.
Evaluation of the Prevalence, Regional Phenotypic Variation, Comorbidities, Risk Factors, and Variations in Response to Different Therapeutic Modalities Among Indian Women: Proposal for the Indian Council of Medical Research–Polycystic Ovary Syndrome (ICMR–PCOS) Study
Authors: Ganie Mohd Ashraf , Chowdhury Subhankar , Suri Vanita , Joshi Beena , Bhattacharya Prasanta Kumar , Agrawal Sarita , Malhotra Neena , Sahay Rakesh , Rozati Roya , Jabbar Puthiyaveettil Khadar , Sreenivas Vishnubhatla , Sriwastva Mukesh , Wani Imtiyaz Ahmad , Singh Shalini , Sharma Radhey Shyam
Published: January 2021

Background

There is scanty data in India on polycystic ovary syndrome (PCOS) from several small, undersized, convenience-based studies employing differing diagnostic criteria and reporting varied regional prevalence. It is difficult to draw clear-cut conclusions from these studies; therefore, the present multicentric, well-designed, large-scale representative countrywide epidemiological study on PCOS across India was conceived with the aim to generate the actual prevalence rates of PCOS in India with a total sample size of approximately 9000 individuals.

Objective

The primary objectives of the study are to estimate the national prevalence of PCOS in India and the burden of comorbidities and to compare the variation in efficacy of standard therapeutic modalities for metabolic dysfunction in women with PCOS.

Methods

This multicentric umbrella study consists of three different substudies. Substudy 1 will involve recruitment of women aged 18-40 years using a multistage sampling technique from randomly selected polling booths across urban and rural areas to estimate national prevalence, phenotypic variation, and risk factors among regions. Substudy 2 involves recruitment of subjects from the community pool of substudy 1 and the institutional pool for quantitation of comorbidities among women with PCOS. Substudy 3, an interventional part of the study, aims for comparison of variation in efficacies of common treatment modalities and will be conducted only at 2 centers. The eligible consenting women will be randomized in a 1:1 ratio into 2 arms through a blinding procedure. All these women will undergo clinical, biochemical, and hormonal assessment at baseline and at 3 and 6 months. The data generated will be analyzed using the reliable statistical software SPSS (version 26).

Results

The study is ongoing and is likely to be completed by April 2022. The data will be compiled and analyzed, and the results of the study will be disseminated through publications.

Conclusions

The Indian Council of Medical Research–PCOS study is the first of its kind attempting to provide accurate and comprehensive data on prevalence of PCOS in India.

Trial Registration

Clinical Trials Registry–India CTRI/2018/11/016252; ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=26366

International Registered Report Identifier (IRRID)

DERR1-10.2196/23437