bluuebunny/crossref_metadata_2025 huggingface dataset:
PREVALENSI Candida albicans PADA PASIEN OTOMIKOSIS DI RSUD MARGONO SOEKARJO
Authors: Wijaya Helmi Aditya , Darmawan Anton Budhi , Nur Hestiyani Rani Afifah , Krisniawati Nia , Rujito Lantip
Published: September 2023

Latar Belakang: Otomikosis merupakan infeksi pada telinga yang disebabkan oleh berbagai macam jamur. Salah satu jamur yang paling umum menyebabkan otomikosis adalah Candida albicans. Otomikosis menjadi suatu tantangan bagi dunia medis dan pasien karena memerlukan pengobatan jangka panjang dan memiliki kekambuhan yang tinggi. Hal itu menyebabkan pentingnya suatu gambaran prevalensi di suatu tempat sebagai perencanaan pelayanan kesehatan, gambaran kasus, dan program pemberantasan. Kabupaten Banyumas memiliki iklim yang menunjang pertumbuhan dari jamur. Salah satu rumah sakit besar yang ada di Banyumas adalah RSUD Margono Soekarjo.
Tujuan: Mengetahui prevalensi Candida albicans pada Otomikosis di RSUD Margono Soekarjo.
Metode: Penelitian ini merupakan penelitian deskriptif observasional pada populasi target pasien di poli THT RSUD Margono Soekarjo. Teknik pengambilan sampel menggunakan total sampling sebanyak 42 subjek dengan 46 sampel. Teknik analisis data menggunakan analisis univariat untuk mendeskripsikan karakteristik tiap variabel.
Hasil: Didapatkan hasil penderita otomikosis di RSUD Margono Soekarjo dengan jenis kelamin laki-laki dibanding perempuan sebesar 50:50 yaitu masing-masing sebesar 21 dari 42 subjek (50,00%). Kelompok usia yang paling banyak menderita otomikosis adalah kelompok usia 26-35 tahun sebesar 12 dari 42 subjek (28,57%). Prevalensi Candida albicans pada Otomikosis sebesar 2,17% atau 1 dari 46 sampel pasien dengan diagnosis klinis otomikosis di RSUD Margono Soekarjo disebabkan oleh jamur Candida albicans.
Kesimpulan: Prevalensi Candida albicans sebagai penyebab otomikosis pada pasien di poli THT RSUD Margono Soekarjo pada periode Januari-Februari 2023 sebesar 2,17% yaitu 1 dari 46 sampel, dengan usia 26 tahun yang masuk ke dalam kelompok usia 26-35 tahun dan berjenis kelamin perempuan.
Authors: Nurjaman Rahmat , Saad Nursan
Published: September 2023

The research uded the qualitative descriptive design. Informants were policy makers and stakeholders in the hospital. The study were conducted through interviews, observation, and documentation. The techniqueds of analysis include several steps: reduction, presentation, and conclusion. The results showed that service performance at Syekh Yusuf local public hospital in Gowa regency, in terms of several dimensions (responsivity, responsibility, and accontabillity) in general, has not achieved an optimum level. This is influenced by several factors, including organisation internal factors (employees, leadership, organisatios facilities, and word prosedure).in general, there are still some weaknesses. And external organisation factors (local finance, economic condition of the community, and social values) have not given optimum support. They still become constraints and challenges in improving service performance in the hospital.
Duality Principles and Numerical Procedures for a Large Class of Non-convex Models in the Calculus of Variations
Authors: Botelho Fabio
Published: September 2023

This article develops duality principles and numerical results for a large class of non-convex variational models. The main results are based on fundamental tools of convex analysis, duality theory and calculus of variations. More specifically the approach is established for a class of non-convex functionals similar as those found in some models in phase transition. Finally, in some sections we present concerning numerical examples and the respective softwares.
Role of Akt/Protein Kinase B in Cancer Metastasis
Authors: Islam Mohammad , Jones Sarah , Ellis Ian
Published: September 2023

Metastasis is a critical step in the process of carcinogenesis and a vast majority of cancer related mortalities result from metastat-ic disease that is resistant to current therapies. Cell migration and invasion are the first steps of the metastasis process, which mainly occurs by two important biological mechanisms i.e., cytoskeletal remodelling and Epithelial to Mesenchymal Transition (EMT). Akt (also known as Protein Kinase B) is a central signalling molecule of the PI3K-Akt signalling pathway. Aberrant acti-vation of this pathway has been identified in a wide range of cancers. Several studies have revealed that Akt actively engages with the migratory process in motile cells, including metastatic cancer cells. The downstream signalling mechanism of Akt in cell migration depends upon the tumour type, sites, and intracellular localisation of activated Akt. In this review, we focus on the role of Akt in the regulation of two events that control cell migration and invasion in various cancers including head and neck squamous cell carcinoma (HNSCC) and the status of PI3K-Akt pathway inhibitors in clinical trials in HNSCC.
Synthesis, Structural, Optical, and Electrical Characterization of Bio-Chitosan/Na0.5Bi0.5TiO3 Composite Thin Films Materials
Authors: Zidani Jacem , Hassine Khaoula , Zannen Moneim , Zeinert Andreas , Da Costa Antonio , FERRI Anthony , Belhadi Jamal , Majdoub Mustapha , El Marssi Mimoun , LAHMAR Abdelilah
Published: September 2023

The purpose of this research work was to synthesis bio-derived nanocomposite films by incorporating Na0.5Bi0.5TiO3 (NBT) nanoparticles into Chitosan matrix. The NBT nanoparticles were synthesized using a traditional solid-state technique. Then, through a solution casting approach, flexible composite films were fabricated using Chitosan polymer. The morphology and structural assessments were carried out utilizing scanning electron microscopy (SEM), X-ray diffraction and fourier transform infrared technique. The SEM micrographs showed that NBT nanoparticles were randomly distributed and interconnected with other particles, forming interconnected grains with substantial interspaces within the matrix. The spectral response between 300 and 800 nm of the composites is mainly governed by light scattering of NBT particles with diameter sizes in the 100 - 400 nm range and the bandgap of the NBT phase. The dielectric studies demonstrated that the composite films exhibited higher dielectric values compared to the pure Chitosan film. Besides, the increase of NBT amount was found to increase the dielectric values. Additionally, local piezoelectric measurements reveal the expected piezoelectric and ferroelectric behavior for the NBT particles dispersed into the polymer matrix, as locally probed by Piezoresponse Force Microscopy. The studied system bears interest for advanced biocompatible opto- and piezo-electric materials.
Electrocardiographic Characteristics, Identification, and Management of Frequent Premature Ventricular Contractions
Authors: Tsiachris Dimitris , Botis Michail , Doundoulakis Ioannis , Bartsioka Lamprini Iro , Tsioufis Panagiotis , Kordalis Athanasios , Antoniou Christos-Konstantinos , Tsioufis Konstantinos , Gatzoulis Konstantinos A
Published: September 2023

Premature ventricular complexes (PVCs) are frequently encountered in clinical practice. The association of PVCs with adverse cardiovascular outcomes in the context of structural heart disease is well established, yet the association between PVCs and cardiovascular outcomes in the absence of structural heart disease is not fully elucidated. Cardiac magnetic resonance (CMR) seems to contribute prognostically in the latter subgroup. PVC- induced myocardial dysfunction refers to the impairment of ventricular function due to the PVCs and is mainly associated with a PVC burden greater than 10%. The surface 12- lead ECG is used to localize the anatomic site of origin and multiple algorithms have been developed to differentiate right ventricular and left ventricular outflow tract (RVOT and LVOT, respectively) origin. Novel algorithms include alternative ECG configurations and lately, sophisticated artificial intelligence methods have been utilized to distinguish the origins of outflow tract arrhythmias. The decision to therapeutically address PVCs should be taken upon the presence of symptoms or the development of PVC- induced myocardial dysfunction. The therapeutic modalities include pharmacological therapy, namely I-C antiarrhythmic drugs and beta blockers, as well as catheter ablation, which demonstrates superior efficacy and safety.
Unsupervised Vehicle Re-identification Method Based on Source-free Knowledge Transfer
Authors: Song Zhigang , Li Daisong , Chen Zhongyou , Yang Wenqin
Published: September 2023

The unsupervised domain-adaptive vehicle reidentification approach aims to transfer knowledge from a labeled source domain to an unlabeled target domain, however there are knowledge differences between the target domain and the source domain. To reduce domain differences, existing unsupervised domain-adaptive rerecognition methods generally require access to the source domain data to assist in re-training the target domain model. But for security reasons, in many cases, data between different domains cannot communicate. To this end, this paper proposes an unsupervised domain-adaptive vehicle re-identification method based on source-free knowledge transfer. First, by constructing a passive domain knowledge migration module, the target domain is consistent with the source domain model output to train a generator to generate the "source-like samples". Then, it can effectively reduce the model knowledge difference and improve the model generalization performance. According to the experiment and testing of VeRi776 and VehicleID, two mainstream public data sets in this field, the rank-k and mAP indexes obtained are both improved, and are suitable for object re-recognition tasks without source data.
Prophylactic Lymphadenectomy in Patients with Penile Cancer: Is Sooner the Better?
Authors: Cai Tommaso , Capece Marco , Zorzi Maria Grazia , Palmieri Alessandro , Barbareschi Mattia , Johansen Truls E. Bjerklund
Published: September 2023

Background: The management of penile cancer patients has some grey zones, one of them being the timing of prophylactic pelvic lymph node dissection. Here, we review the impact of timing of prophylactic inguinal and pelvic lymph node dissection on patients’ outcome. Methods: Relevant databases were searched according to recommendations by the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Before the systematic review we present a narrative review on the indications for lymph node dissection and the impact of pathological anatomical considerations on the timing of prophylactic lymph node dissection and patients’ outcome. The primary research questions were disease-free and overall survival rate in patients who underwent early or late lymph node dissection after penile cancer diagnosis. Results: Four clinical trials were included in the systematic review. Conclusions: The survival rate of patients with penile cancer is strictly associated with the timing of prophylactic pelvic lymph node dissection. Even though there are no randomized controlled trials we conclude that there is evidence for a strong recommendation that lymph node dissection should be performed as soon as possible after diagnosis with3 months as a realistic cut-off time between early and late. According to the present evidence base, lymph node dissection should be offered the sooner the better to all patients at high risk of lymph node metastasis.
Asymmetric Probabilistic Tsetlin Machine for Pattern
Recognition
Authors: Elmisadr Negar , Belaid Mohamed Bachir , Yazidi Anis
Published: September 2023

This article introduces a novel approach, termed the Asymmetric Probabilistic Tsetlin (APT) Machine, which incorporates the Stochastic Point Location (SPL) algorithm with the Asymmetric Steps technique into the Tsetlin Machine (TM). APT introduces stochasticity into the state transitions of Tsetlin Automata (TA) by leveraging the SPL algorithm, thereby enhancing pattern recognition capabilities. To enhance random search processes, we introduced a decaying normal distribution into the procedure. Meanwhile, the Asymmetric Steps approach biases state transition probabilities towards specific input patterns, further elevating operational efficiency.

The efficacy of the proposed approach is assessed across diverse benchmark datasets for classification tasks. The performance of APT is compared with traditional machine learning algorithms and other Tsetlin Machine models, including the Asymmetric Tsetlin (AT) Machine, characterized by deterministic rules for Asymmetric transitions, and the Classical Tsetlin (CT) Machine, employing deterministic rules for symmetric transitions. Strikingly, the introduced APT methodology demonstrates highly competitive outcomes compared to established machine learning methods. Notably, both APT and AT exhibit state-of-the-art performance, surpassing the Classical Tsetlin Machine, emphasizing the efficacy of asymmetric models for achieving superior outcomes. Remarkably, APT exhibits even better performance than AT, particularly in handling complex datasets.
Process Evaluation of a Pain Management Educational Intervention for Parents of Children Undergoing Elective Surgery
Authors: Zhu Lixia , Huang Chuanya , Chan Wai-Chi Sally , Ng Sixian , Liam Joanne Li Wei , Cheng Kin Fong Karis , He Hong-Gu
Published: September 2023

Purpose: To explore parents’ perceptions of the educational intervention programme regarding their children’s postoperative pain management.

Design and Methods: A qualitative descriptive study was conducted. Thirty-two parents whose children underwent inpatient elective surgery were recruited from the two intervention groups (received an educational booklet and a video, with or without an hour of face-to-face teaching session) for this qualitative evaluation of the intervention. Participants were asked to comment on the content and delivery methods of the intervention via individual face-to-face semi-structured interviews. Thematic analysis was used to identify themes from the data.

Results: Three themes were generated from 32 participants’ interview data: current pain management practices, experiences and benefits of the educational intervention, and suggestions to improve pain management.

Conclusions: Our findings suggested that the educational intervention in children’s postoperative pain management was helpful for parents and their children. However, it is necessary to improve educational materials and equip healthcare professionals with non-pharmacological pain relief methods.

Practice Implications: Our findings reveal the current challenges in extensively adopting non-pharmacological pain relief methods. Healthcare professionals can do more to routinely integrate pharmacological and non-pharmacological pain management strategies in relieving pain effectively. Future research could develop technology-based programmes to increase ease of access.

Trial Registration Number: ISRCTN24910957.
THE CORRELATION BETWEEN IgM/IgG DENGUE SEROLOGICAL TEST AND THROMBOCYTE HEMATOCRIT COUNT ON DHF PEDIATRIC PATIENTS AT UNS HOSPITAL
Authors: Maulani Utiya Nabila , Hanafi Muchtar , Mashuri Yusuf Ari , Kamenyangan Sari Maria Galuh
Published: September 2023

Background: Dengue hemorrhagic fever (DHF) is an infectious disease transmitted by the Aedes aegepty mosquito and mostly occurs during the rainy season. This disease can affect all age groups but the occurrence was quite high in children. Supporting examinations and complete blood counts are required to establish the diagnosis of DHF. This study aims to determine the correlation between the results of IgM/IgG dengue serological test and thrombocyte hematocrit count.

Methods: This cross-sectional study was conducted in the UNS Hospital from November to December 2020 and obtained 134 samples that match the inclusion and exclusion criteria. Secondary data were obtained from the medical records of DHF child patients who met the criteria of inclusion and exclusion. Thrombocyte and hematocrit counts were analyzed using chi-square test and Fisher exact test.

Result: This study showed no significant correlation between the serologic test of IgM/IgG dengue and thrombocyte with a value p = 0.451 (p>0.05). There was also no significant correlation between the serologic test of IgM/IgG dengue and hematocrit (p= 0156, p>0.05) on DHF pediatric patients at UNS Hospital.

Conclusion: Thus the serologic test of IgM/IgG of dengue had no correlation with thrombocyte and hematocrit count on DHF pediatric patients at UNS Hospital.
The Representation of ICT Competencies in English Language Reading Skill Modules for Open University
Authors: Sanjaya Jody Furqon , Sumarni Sri
Published: September 2023

The current global and national issues require students to upgrade their level of ICT competencies in this 21st century. To meet the new standard, there is a need to upgrade the development of the learning materials. Therefore, this study is aimed to portray the ICT competencies covered in the reading skill modules as a concern in addressing the issue of ICT competencies development in education. The qualitative content analysis is used as the method of this study. The main source of data is reading skills modules which are taken from four reading courses (Reading I, II, III, and IV) in Open University English Education Study Program. The results of this study show that 90 representations of ICT competencies are found and mostly represented in the form of Hypermedia, followed by Hyperlink, Multimedia (graphs, tables, and diagrams) and Communication Media (e-mail). The analysis of the table of ISTE NETS (2016) shows that Knowledge Constructor is the most dominant standard (74%), followed by Computational Thinker (16%), and Creative Communicator (10%).
PENGARUH PENINGKATAN LAHAN TERBANGUN TERHADAP PENURUNAN PERMUKAAN TANAH DI KOTA JAKARTA UTARA TAHUN 2012-2022
Authors: Andri Andri Noor Ardiansyah
Published: September 2023

Penelitian ini bertujuan untuk mengetahui pengaruh peningkatan lahan terbangun terhadap penurunan permukaan tanah di Kota Jakarta Utara tahun 2014-2022. Penelitian ini menggunakan pendekatan kuantitatif dan jenis penelitian deskriptif.  Penelitian ini menggunakan teknik pengolahan penginderaan jauh dan sistem informasi geografi (SIG) dengan menggunakan data Citra Landsat 8 dan Sentinel 1 tahun 2014 dan tahun 2022, pengolahan dilakukan melalui platform Google Earth Engine. Pada variabel peningkatan lahan terbangun dilakukan analisis menggunakan metode kalsifikasi terbimbing (supervised classification) menjadi 2 klasifikasi yaitu lahan terbangun dan lahan non terbangun. Dan untuk mendapatkan nilai penurunan permukaan tanah dilakukan analisis DInSAR (Different Interferometric Synthetic Aperture Radar). Kemudian untuk mengetahui nilai pengaruh antara variabel peningkatan lahan terbangun  dengan variabel penurunan permukaan tanah (  dilakukan analisis regresi linear sederhana dengan persamaan Y = 6,413 + 13,178X menghasilkan nilai signifikansi sebesar 0,000<0,05. Nilai R Square sebesar 0,466 yang artinya terdapat pengaruh peningkatan lahan terbangun terhadap penuruan permukaan tanah sebesar 46,6%. Sedangkan nilai thitung diperoleh hasil sebesar 9,239 dan nilai ttabel sebesar 0,1966 dan memiliki arti thitung>ttabel. Sehingga dapat disimpulkan Ha ditolak dan Ha diterima, yang artinya terdapat pengaruh yang signifikan antara peningkatan lahan terbangun terhadap penurunan permukaan tanah di Kota Jakarta Utara tahun 2014-2022.
The Incorporation of Higher Order Thinking Skills in Ruangguru Application for Senior High School Tenth Graders
Authors: Aulia Fulky , Permana Sudarya
Published: September 2023

This study is a content analysis that attempts to analyze the incorporation of higher-order thinking skills based on Bloom’s revised taxonomy in English multiple-choice questions for tenth graders at Ruangguru application. Ten chapters of English subject for tenth graders including 120 randomly selected questions in the English exercises at the application were chosen as data source of this study. The findings show that the questions incorporate the order thinking skills with a percentage of 50,8% of lower-order thinking skills (LOTS) and 49,2% of higher-order thinking skills (HOTS), which means that both are not evenly distributed in every chapter. The most dominant level found in this study is evaluation, which includes checking and critiquing, with a percentage of 25,8%. The incorporation of HOTS in Ruangguru application has been proven, but the result cannot be generalized since not all students in Indonesia use the application. Thus, HOTS analysis to other learning applications, other grades, and/or other subjects are encouraged to be conducted to picture out the incorporation of HOTS in greater coverage.
Investigating Character-Building Values in English Textbook Entitled Bahasa Inggris for Grade X
Authors: Amelia Nabilla Puspa , Permana Sudarya
Published: September 2023

This research aims to investigate (1) the character-building values presented in the English textbook entitled Bahasa Inggris for grade X, and (2) the way character-building values were presented into its materials. The researcher referred to 18 character-building values mandated by the Ministry of National Education (2010). This research used a qualitative research method using content analysis. The data used in this research were the sentences contained in this textbook. The results showed that the English textbook entitled Bahasa Inggris for grade X contained all the character-building values, the most of which was the friendly/communicative value with percentage of 16% and the least of which was the tolerance value with percentage of 1%. There were two techniques of integrating characters that were found in the textbook, namely explicit and implicit techniques. The results of this study are expected to be able to give instances to the English teachers so that they can appropriately give these characters to students and be more selective in choosing a textbook or a learning method.
An Analysis of Translation Error that Occurs among English Foreign Language Students
Authors: Kheryadi  , Magfiroh Siti
Published: September 2023

The quality of translation can affect the quality of information conveyed. However, errors often occur. It is evidenced by the various errors that can be found in this study. The objectives of this study are: 1) To check types of translation errors in Indonesian to English translation. 2) To find the possible explanations for the sources of errors made by the students in translation. The researcher hopes that it can help students to enrich their knowledge about learning translation. The methodology of this study was qualitative in case study design. The data was obtained from student tests. Researchers also conducted interviews to find out the source of the translation error. It analyzed the data and calculated each error with frequency and percentage. The respondents of this study were English Foreign Language students of Class TBI-E 2016 of UIN SMH Banten. They made some errors when they translated text from Indonesian into English. The researcher found that each error was a syntax error (68.13%), then a semantic error (31.87%). Researchers also found sources of translation errors: lack of linguistic understanding, translation procedures, unconfident, and inattention. The recommendation from the researcher is to inform students about the correct translation procedure. Moreover, more tasks about vocabulary and structure hope to be able to increase their English skill
The Incipits of Semi-Popular Articles about Language Learning
Authors: Madani Yolanda Puteri , Darya I Wayan
Published: September 2023

This study aims to identify the type of organization incipit used and analyze the language features of organization incipit in semi-popular science article. This research was conducted by using qualitative methods and employs a corpus-driven analysis approach. The approaches are conducted by adopting Hyland’s framework of proximity, specifically the organization facet of incipits position. After analyzing the data, the study found incipits in the semi-popular article can be broadly categorized into 5 categories and the most used category is ‘research finding’, followed by ‘establishment of a common ground’, then ‘contextualization of the article’, after that is ‘research problem’ category, and the least identified category is ‘benefit of the finding’. This study also found language feature of each category, like word frequency, concordance, and content organization is the one that identifies each category from the other.
Cultural Contents in Digital Authentic Greeting Cards as English Teaching Materials for Junior High Schools
Authors: Angelina Shely , Mayuni Ilza , Agustina Imas Wahyu
Published: September 2023

This study aimed to discover the cultural contents in the digital authentic greeting cards as English teaching materials for junior high schools. The research data were the cultural values in the form of words, phrases, clauses, or sentences that are contained in the texts on the digital authentic greeting cards. The data sources were taken from several websites providing free digital greeting cards to be downloaded. The data were analyzed with the framework of the cultural dimensions by Moran (2001) and the cultural sources by Chao (2011) by using a qualitative content analysis method. The findings revealed 101 cultural contents that were classified into the four cultural dimensions and three sources of culture. The cultural contents were mostly identified in the Universality across Culture and represented by the Practices dimension through activities and language expressions. It was indicated that a large proportion of the cultural contents were included in universal contents that are not specific to any particular country and were represented by actions and interactions carried out by the cultural members.
The Incorporation of Digital Literacy in EFL Learning Materials for Senior High School Students
Authors: Agusprayuningtyas Nadila Farah , Iskandar Ifan , Dewanti Ratna
Published: September 2023

Digital literacy is an important ability to have to succeed in today's era where almost everything is surrounded by digital technologies, tools, services, and so on. This study aims to investigate to what extent digital literacy is incorporated in EFL learning materials for senior high school students, and to describe how digital literacy is incorporated in EFL learning materials. This qualitative study uses content analyses in analyzing the 36 learning materials that have been collected from 4 different public senior high schools in the East Jakarta area from 4 different teachers. This present study found that digital literacy is not yet maximally incorporated into the learning materials. Out of 36 English learning materials, only 16 English learning materials seem to be incorporated with digital literacy indicators, while some others didn't even incorporate digital literacy at all. Digital literacy in learning materials is incorporated in many ways; instruction (43 occurrences), task (31 occurrences), text (8 occurrences), and last is the provision of links (3 occurrences).
Cultural Contents in MyEnglishStep Digital Learning Materials for Junior High School Students
Authors: Maulidya Alga Dilfa Suci , Palupi Tara Mustikaning , Agustina Imas Wahyu
Published: September 2023

The present research aimed to analyze the cultural contents available in digital learning materials for Junior High School Students called myenglishstep.com. The data were analyzed using qualitative content analysis under two frameworks, particularly the cultural categories framework by Chao (2011) and the framework of the cultural dimensions by Moran (2001). The results revealed 1.472 cultural contents, covering all five cultural categories: Source Culture, Target Culture, International Culture, Intercultural Interaction, and Universality across Cultures. Further, the cultural contents are also represented through Cultural Dimensions, namely Products Dimension, Practices Dimension, Perspectives Dimension, Communities Dimension, and Person Dimension. The cultural contents mainly appeared as much as 1160 times in the Universality across Cultures and were presented through products created and invented by the social communities approximately 623 times. These results, to some extent, show that material developers are aware of the importance of cultural content to cater to diversity in Indonesia.
The Incorporation of Digital Citizenship Competency in e-Learning Materials for Junior High School Students: A Content Analysis
Authors: Kamaliya Vikasari , Mayuni Ilza , Palupi Tara Mustikaning
Published: September 2023

This study aims at investigating the way Digital Citizenship Competencies (DCC) are incorporated into digital learning materials (DLM) in a web-based learning platform called myenglishstep.com. By compiling 115 DLM of 7th up to 9th Grade and utilizing the content analysis method, the finding shows skills dimension is found to be the highest incorporation, followed by the knowledge dimension. In contrast, the attitudes and values dimension showed low occurrences compared to the previous dimension. Knowledge, skills, and attitudes dimensions of DCC are mostly incorporated in all DLM categories through tasks, contents, and visuals, while values dimensions are incorporated through contents for the most part and tasks. Therefore, these findings are expected to raise people's awareness of digital citizenship competencies and aid teachers and stakeholders in providing reliable and varied digital learning materials.
The Incorporation of the 4C Skills in the Lesson Plans of Grade Eight
Authors: Luthfi Nadia , Agustina Imas Wahyu , Pujiati Hanip
Published: September 2023

This research aimed to investigate the incorporation of the 4C skills in the lesson plans and to analyze how the 4C skills were implemented into the lesson plans of English for grade eight. The data for this qualitative content analysis research was gathered by analyzing ten lesson plans for grade eight of junior high school in Bekasi and Jakarta. The research found that all the lesson plans included all the 4C skills, which comprised 51% of communication skills, 69% of collaboration, 61% of critical thinking, and 69% of creativity. As the most widely incorporated, collaboration and creativity were found in learning and assessment activities. These findings are expected to be a recommendation for scholars, especially English teachers in designing lesson plans that meet 21st-century skill needs.
Approach to modeling of distributed hierarchical control for autonomous drone swarm
Authors: Shyian Anatolii
Published: September 2023

Control of a drone swarm as a unit requires decentralization and hierarchy. Decentralizing control of the drone swarm is necessary to free the human-operator from having to constantly control the behavior of the drones within the swarm. Hierarchical control of a drone swarm is necessary so that a human-operator can adjust the activity of the swarm as a unit (as a whole). To implement this approach, the control model is proposed. The following separate roles have been identified for the implementation of decentralized hierarchical control of swarm activity: the activity of a separate drone, the activity of a drone- coordinator, and the activity of a human-operator. The control hierarchy consists of a human-operator who controls the change in the behavior of the drone-coordinator. The drone-coordinator controls the changes in the behavior of individual drones in the swarm. Drones in a swarm perform programmed behavior. This approach allows us to consider the control of a drone swarm as an analog of the management of human-workers who perform assigned work. This opens up several possibilities. First, it is possible to use methods of formalizing people’s behavior in social teams. For example, at the level of formal models of performance of their functional duties. Second, formal models can be used for decision-making and optimization for controlling a drone-coordinator in a swarm. Thirdly, computer modeling can be applied to the behavior of a drone swarm, which will allow choosing the optimal behavior of the swarm for different conditions of its activity.
Immobilization of β-glucosidase from Moniliophthora perniciosa on different supports by adsorption
Authors: Almeida Larissa Emanuelle da Silva , Fernandes Pedro , de Assis Sandra Aparecida
Published: September 2023

Enzyme immobilization allows the reuse of the biocatalyst more than once without excessive loss of its catalytic activity and conveys operational and storage stability. In this work, β-glucosidase produced extracellularly by the filamentous fungus Moniliophthora perniciosa was immobilized by adsorption on Celite, silica, and chitosan. Celite was the chosen carrier for immobilization due to the high activity yield and maintenance of 65% ± 1.9 of its initial activity after seven reuses. The activity of the immobilized β-glucosidase peaked at pH 4 at a temperature of 60°C. Moreover, the immobilized enzyme retained 23.7% ± 4.85 when maintained at temperature of 90°C during 60 min. At 60°C and 80°C, it maintained more than 70% of the initial activity after 20 minutes of incubation.
Comparison of the prevalence of osteoporosis in people with spinal cord injury according to bone mineral density reference values for the diagnosis of osteoporosis
Authors: Lim Jisun , Kim Onyoo
Published: September 2023

Background
This study aimed to compare the osteoporosis prevalence among Korean adults aged ≥ 50 years with spinal cord injury (SCI) according to bone mineral density (BMD) reference values (BMDRV) for diagnosing osteoporosis.
Methods
This retrospective cross-sectional study included 855 SCI patients who underwent BMD tests of the lumbar spine, femoral neck, and total hip in the National Rehabilitation Center in Korea between 2010 and 2020.Osteoporosis was diagnosed in SCI patients by comparing differences in prevalence, diagnostic consistency, and risk factors according to the region-based BMDRV of the dual-energy x-ray absorptiometry (DXA) manufacturer and international BMDRV according to the Third National Health and Nutrition Examination Survey (NHANES III) data of females aged 20–29 years.
Results
The prevalence of osteoporosis according to the T-score provided by a single reference population of the NHANES (PONHA) (males: 26.69%; females: 69.35%) was significantly higher in females and males than the prevalence of osteoporosis according to the T-scores provided by the DXA manufacturer (PODXA) (males: 15.32%; females: 43.15%). The lumbar spine and femoral neck were major osteoporosis diagnosis sites for the PODXA and PONHA, respectively. Risk factors for osteoporosis differed based on the probability of osteoporosis (also called the OZ ratio) according to the BMD criteria; however, risk factors were the same based on old age, female sex, low BMD, and long SCI period. No significant relationship was noted between different SCI-related clinical factors (p > 0.05)
Conclusions
Further studies on BMDRV are warranted to establish accurate diagnostic criteria for preventing osteoporosis in patients with SCI.
Application of the β-glucosidase from the fungus Kretzschmaria zonata on sugarcane bagasse hydrolysis
Authors: Canettieri Danilo , Pimentel Debora , Almeida Lucas , Gomes Riziane , Clevelares Yan , Guimarães Valéria , Maitan-Alfenas Gabriela
Published: September 2023

β-glucosidases for industrial applications are mainly obtained from filamentous fungi. Kretzschmaria zonata is a phytopathogenic fungus that produces an arsenal of enzymes with biotechnological potential and this work aimed to produce, to purify and to characterize a β-glucosidase from the fungus K. zonata for its application in supplementation of a commercial cocktail for sugarcane bagasse saccharification. The higher specific activity of β-glucosidase was induced by corn cob, 1.085 U/mg of protein. At the end of all purification steps, a purification factor of 6.52 was reached, with an increase of specific activity from 1.22 U/mg, in the crude extract, to 7.97 U/mg. Concerning pH stability, at pH 4, the pH of maximal β-glucosidase activity, the enzyme was completely stable, with 100% of activity after 1 h of incubation, while it kept over than 50% of activity in the pH range from 2.2 to 6. The optimum temperature was 60°C and he half-life times were estimated as 307.8 and 10 min, for temperatures of 60 and 70°C, respectively. The β-glucosidase showed a reduction in relative activity in the presence of 10 mM of manganese sulfate, zinc sulfate, manganese chloride, SDS and glucose, maintaining 55, 56, 62, 70, 73% of the relative activity, respectively. The commercial cocktail supplemented with the K. zonata β-glucosidase enabled the release of 13.89 g/L of glucose and 5.34 g/L of xylose, an increase of 19.8 and 35.5% of glucose and xylose release, respectively, after sugarcane bagasse hydrolysis.
A PLC-based pomegranate sprout removal device design
Authors: Qiu Liqi , Sun Jingbin , Zhang Xieliang , Sun Qun , Zhao Ying
Published: September 2023

In order to liberate manual labor, reduce Labor burden and improve the efficiency of cutting pomegranate sprouts, this paper designed a pomegranate sprout cutting machine. Based on SOLIDWORKS software, 3D digital design and overall assembly of key components were carried out; Adopting PLC FX3U-32MT to control the stepper motor, cylinder and other related execution components, achieving the removal of sprouts and the removal of interfering branches and leaves; Control the actual operation of related structures using the MCGS configuration software control interface. Real time determination of cutting position, achieving the cutting of sprouts under different growth conditions. According to experimental measurements, the removal rate of sprouts in this device can reach 74.62%, and the damage rate can reach 18%. This device can promote the development of mechanical semi-automatic cutting in the field of pomegranate sprouting.
Developing a theory of change to guide the design and implementation of a Caregiver- Centric Support Service
Authors: WU Ling Ting , GLASS George Frederick , CHEW Esther Yin Hui , Ng Emmalene Joo Yong , CHAN Ee Yuee
Published: September 2023

Background: Set against the backdrop of a rapidly ageing population and growing emphasis on the importance of ageing-in-place, family members often assume the role of a caregiver. Navigating through a complex healthcare system while simultaneously juggling the daily care needs of their care-recipients, caregivers often become worn out by the intense caregiver stress and burden, neglecting their own well-being. This translates to adverse health and economic outcomes such as prolonged hospital stays and increased nursing home placement of care-recipients. Seeking to better support caregivers, we developed a theory of change to guide the design and implementation of a caregiver support programme – Project Carer Matters.
Methods: We applied theory of change methodology to explain how the Project’s interventions were hypothesised to lead to their identified short-to-long term goals, drawing on a causal analysis based on available evidence. The theory of change was developed with insights garnered from previous research studies conducted on caregiver stress, stakeholder engagement sessions and multiple dialogues with clinical experts and hospital leaders.
Results: Our final theory of change is the result of the evaluation of the Project in its pilot phase. It is populated with the resources, activities and short-to-long term outcomes that can be attributed or linked to the Project. Multiple meetings and discussion with stakeholders over the pilot prompted frequent practice of the Plan, Do, Study, Act model to refine the ongoing implementation process and the theory of change itself.
Conclusions: A theory of change is essential in guiding the design, implementation and evaluation of a complex health care intervention such as Project Carer Matters. The development of the theory of change is a journey and not a resultant product. This journey has also led us to learn that 1) a theory of change needs to be dynamic and ever evolving with time and context, 2) the perspectives of relevant stakeholders need to be included in this process to ensure the feasibility and sustainability of the project in the long run and 3) frequent stakeholder engagements are essential in enabling the implementation team to fine-tune the Project in an effective manner.
Trial Registration: ClinicalTrials.gov, NCT05205135, registered on 24/01/2022.
The Quality of Acupuncture Recommendations for Migraine in Global Headache Guidelines: A Systematic Review Using the AGREE II and AGREE-REX Instruments
Authors: Cui Shuo , Wang Xiao-Yu , Hu Jing , Chen Zhong-Jjie , Huo Jin , Gao Qi , Liu Lu , Wang Jing-Jing
Published: September 2023

Background and objective: This study aims to identify the quality of acupuncture recommendations for migraine in global headache guidelines. Methods: Global migraine guidelines published before June 2022 were searched and screened. The AGREE II (Appraisal of Guidelines for Research & Evaluation II) and AGREE-REX (The Appraisal of Guidelines Research & Evaluation Recommendation Excellence) were used to evaluate the reporting quality, methodology quality, and acupuncture recommendations in the included guidelines. Results: Of the 16 guidelines included, 14 recommended acupuncture treatment for migraine (8 were rated as B by AGREE II, and 6 were rated as C), while 2 recommended against acupuncture treatment (rated as C). One guideline described detailed manipulations (1/14), two described treatment sessions and courses (2/14), and 11 only indicated that acupuncture was effective but without a specific treatment plan mentioned (11/14). The results of the AGREE-REX showed that all 16 guidelines scored relatively high only in the “Evidence” item (mean score: 57.29%), whereas the scores of the other 8 items were low. Conclusions: Among the current headache guidelines around the world, the number of guidelines recommending acupuncture for migraine treatment is small, the content of recommendations involving acupuncture treatment is limited, and the recommendations for detailed acupuncture treatment programs are insufficient. Within the included guidelines recommending acupuncture for migraine treatment, the report quality, methodology quality, and quality of acupuncture recommendations are low; therefore, it is difficult to meet clinical needs.
Downregulation of SSR2 enhanced the sensitivity of hepatocellular carcinoma cells to cisplatin through Hippo pathway
Authors: Ye Rong , Yin Ling , Ge Yilong , Zhu Xiansen , Xiao Yuansheng , Fang Cuifu , Liu Qingquan , Zhang Honghui , Li Heping , Xie Binhui
Published: September 2023

Background Chemotherapy resistance is an obstacle to promote the survival of patients with hepatocellular carcinoma (HCC). Therefore, it is essential to find out the promising therapeutic targets to enhance the sensitivity of chemotherapy in HCC.Methods qPCR and western blotting assay were used to examine the expression of signal sequence receptor subunit (SSR2). Colony formation, flow cytometry assay, anchorage independent growth assay and in vivo animal model were used to investigate the effect of SSR2 on resistance of HCC cells to DDP. Western blotting, Luciferase reporter gene technique were used to explore the molecular mechanism of SSR2 on resistance of HCC cells to DDP.Results We found signal sequence receptor subunit (SSR2) is significantly upregulated in HCC, which leads to poor survival. Further analysis showed Downregulation of SSR2 increased sensitivity of HCC cells to DDP. Mechanically, SSR2 inhibited the phosphorylation of YAP and promoted the transcription of Hippo signaling downstream genes. Finally, the inhibitor of Hippo pathway can suppress colony formation and tumorigenesis arousing by upregulation of SSR2.Conclusions Our study provided evidence SSR2 played an important role in HCC progression via Hippo pathway, thus targeting SSR2/Hippo pathway axis might be an effective strategy to overcome DDP resistance in HCC.
Effects of two different surgical methods for endovascular repair of the thoracic aorta on the hemodynamics of the left subclavian artery
Authors: Li Xiaowei , Yuan Xiaoming , Wen Zan , Bi Wei
Published: September 2023

Background: Some clinicians use endograft to partially cover the left subclavian artery (LSA) ostium or multilayer flow modulator (MFM) to mitigate cases with an insufficient landing area in thoracic endovascular aortic repair(TEVAR) treatment. So we used computational fluid dynamics (CFD) to study the effects of two surgical methods on the hemodynamics of the LSA, due to they may affect the long-term patency rate of the LSA.
Methods: The digital model of the aortic arch was established and named model A, which only included supraarch branch the LSA. The simulated digital model of the MFM was implanted into model A, named as model B. By directly covering one half of the LSA ostium, which was named as model C. All established models were imported into the Gambit grid division software for grid division and were subsequently imported into the Fluent software for hemodynamic numerical simulation and calculation. The changes in the related hemodynamic parameters of the LSA after implantation of the two stents were analyzed and compared.
Results: Under the same aortic inlet flow, in model C, the lumen flow of the LSA was obviously reduced and the distal descending aorta flow was increased, the local blood flow velocity of LSA ostium increased and whole blood flow velocity at the distal end decreased. The average wall shear stress(WSS) of the LSA was significantly decreased. Meanwhile there was an obvious turbulent flow in the LSA lumen, and the related blood flow state was disordered. However, all changes in model B was occured, they changed slightly compared with model A.
Conclusion: CFD research confirmed that the implantation of an MFM had little influence on the hemodynamics of the LSA. In contrast, the implantation of an endograft partially covering the LSA ostium increased the local ostium velocity. But it reduced the global flow rate, velocity, and average wall shear stress at the distal end. This change is likely to cause a long-term hardening and an acute thrombosis of the LSA artery. Nevertheless, this operation can also be used in specific clinical cases.