bluuebunny/crossref_metadata_2025 huggingface dataset:
Unlocking the potential of glyphosate-resistant bacterial strains in biodegradation and maize growth
Authors: Mohy-Ud-Din Waqas , Chen Feng , Bashir Safdar , Akhtar Muhammad Javed , Asghar Hafiz Naeem , Farooqi Zia Ur Rahman , Zulfiqar Usman , Haider Fasih Ullah , Afzal Aneeqa , Alqahtani Mashael Daghash
Published: December 2023

Glyphosate [N-(phosphonomethyl)-glycine] is a non-selective herbicide with a broad spectrum activity that is commonly used to control perennial vegetation in agricultural fields. The widespread utilization of glyphosate in agriculture leads to soil, water, and food crop contamination, resulting in human and environmental health consequences. Therefore, it is imperative to devise techniques for enhancing the degradation of glyphosate in soil. Rhizobacteria play a crucial role in degrading organic contaminants. Limited work has been done on exploring the capabilities of indigenously existing glyphosate-degrading rhizobacteria in Pakistani soils. This research attempts to discover whether native bacteria have the glyphosate-degrading ability for a sustainable solution to glyphosate contamination. Therefore, this study explored the potential of 11 native strains isolated from the soil with repeated glyphosate application history and showed resistance against glyphosate at higher concentrations (200 mg kg−1). Five out of eleven strains outperformed in glyphosate degradation and plant growth promotion. High-pressure liquid chromatography showed that, on average, these five strains degraded 98% glyphosate. In addition, these strains promote maize seed germination index and shoot and root fresh biomass up to 73 and 91%, respectively. Furthermore, inoculation gave an average increase of acid phosphatase (57.97%), alkaline phosphatase (1.76-fold), and dehydrogenase activity (1.75-fold) in glyphosate-contaminated soil. The findings indicated the importance of using indigenous rhizobacteria to degrade glyphosate. Therefore, by maintaining soil health, indigenous soil biodiversity can work effectively for the bioremediation of contaminated soils and sustainable crop production in a world facing food security.
Biogeographic distribution of autotrophic bacteria was more affected by precipitation than by soil properties in an arid area
Authors: Wang Ying , Huang Yimei , Zeng Quanchao , Liu Dong , An Shaoshan
Published: December 2023

Introduction

Autotrophic bacteria play an important role in carbon dioxide fixation and are widespread in terrestrial ecosystems. However, the biogeographic patterns of autotrophic bacteria and the driving factors still remain poorly understood.

Methods

Herein, we conducted a 391-km north to south transect (mean annual precipitation <600 mm) survey in the Loess Plateau of China, to investigate the biogeographic distributions of autotrophic bacteria (RubisCO cbbL and cbbM genes) and the environmental drivers across different latitude sites with clear vegetational and climatic gradients.

Results and discussion

The soils in northern region with lower precipitation are dominated by grassland/forest, which is typically separated from the soils in southern region with higher precipitation. The community structure of autotrophic bacterial cbbL and cbbM genes generally differed between the soils in the southern and northern Loess Plateau, suggesting that precipitation and its related land use practices/ecosystem types, rather than local soil properties, are more important in shaping the soil autotrophic microorganisms. The cbbL-containing generalist OTUs were almost equally abundant across the northern and southern Loess Plateau, while the cbbM-containing bacterial taxa were more prevalent in the low precipitation northern region. Such differences indicate differentiate distribution patterns of cbbM- and cbbL-containing bacteria across the north to south transect. Our results suggest that the community composition and the differentiate distributions of soil cbbL- and cbbM-containing bacterial communities depend on precipitation and the related ecosystem types in the north to south transect in the Loess Plateau of China.
Do we all synch alike? Brain–body-environment interactions in ASD
Authors: Beker Shlomit , Molholm Sophie
Published: December 2023

Autism Spectrum Disorder (ASD) is characterized by rigidity of routines and restricted interests, and atypical social communication and interaction. Recent evidence for altered synchronization of neuro-oscillatory brain activity with regularities in the environment and of altered peripheral nervous system function in ASD present promising novel directions for studying pathophysiology and its relationship to ASD clinical phenotype. Human cognition and action are significantly influenced by physiological rhythmic processes that are generated by both the central nervous system (CNS) and the autonomic nervous system (ANS). Normally, perception occurs in a dynamic context, where brain oscillations and autonomic signals synchronize with external events to optimally receive temporally predictable rhythmic information, leading to improved performance. The recent findings on the time-sensitive coupling between the brain and the periphery in effective perception and successful social interactions in typically developed highlight studying the interactions within the brain–body-environment triad as a critical direction in the study of ASD. Here we offer a novel perspective of autism as a case where the temporal dynamics of brain–body-environment coupling is impaired. We present evidence from the literature to support the idea that in autism the nervous system fails to operate in an adaptive manner to synchronize with temporally predictable events in the environment to optimize perception and behavior. This framework could potentially lead to novel biomarkers of hallmark deficits in ASD such as cognitive rigidity and altered social interaction.
Clinical characteristics and prognostic analysis of acute necrotizing encephalopathy of childhood: a retrospective study at a single center in China over 3 years
Authors: Fang Yu , Gao Qiqi , Jin Wenwen , Li Jianshun , Yuan Hao , Lin Zhenlang , Pan Guoquan , Lin Wei
Published: December 2023

Objective

Acute Necrotizing Encephalopathy of Childhood (ANEC) is a rare, fulminant neurological disease in children with unknown mechanisms and etiology. This study summarized the clinical characteristics, treatment, and prognosis of ANEC through a retrospective analysis, providing insights into the ANEC early diagnosis and prognosis assessment.

Methods

Clinical data of children diagnosed with ANEC at the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University from July 1, 2020, to June 30, 2023, were retrospectively analyzed.

Results

There were 25 cases, 14 males and 11 females, with a median age of 3 years. Hospital admissions were mainly in the winter (14/25, 56%) and spring (9/25, 36%). All patients presented with varying degrees of fever and altered consciousness, with 92% (23/25) experiencing high body temperatures (>39.1°C) and 88% (22/25) having a Glasgow coma scale (GCS) score of ≤8. Seizures were observed in 88% (22/25) of patients. Laboratory findings indicated 100% B lymphocyte activation (14/14), and 78% (14/18) of patients showed cytokine storm (interleukin (IL)-6, IL-8, IL-10, interferon (IFN)-α). Neuroimaging showed symmetrical thalamus involvement, commonly involving basal ganglia and brainstem regions. Viral infection (23/24, 96%) was the predominant etiological finding, with 42% (10/24) of cases due to SARS-CoV-2 infection and 42% (10/24) to influenza A virus infection. Multi-organ dysfunction occurred in 68% (17/25) of patients, and 52% (13/25) died. Correlation analysis revealed the death group exhibited higher proportion of male, lower GCS scores, higher IL-6 level and a greater likelihood of associated brainstem impairment (p < 0.05).

Conclusion

ANEC is more prevalent in the winter and spring, and its etiology may be associated with B lymphocyte activation and cytokine storm following viral infections. Clinical manifestations lack specific features, with fever, consciousness disturbances, and seizures being the main presentations, particularly in cases of high fever and hyperpyrexia. ANEC progresses rapidly and has a high mortality rate. The child’s gender, GCS score, IL-6 levels, and the presence of brainstem involvement can serve as important risk factors for assessing the risk of mortality.
Scalp electroacupuncture targeting the VTADA neurons to relieve negative emotions and promote the alleviation of chronic pain
Authors: Yang Yanan , Wei Xiali , Tian Jun , Zhu Ye , Jia Shaohui , Shu Qing
Published: December 2023

Object

Chronic pain and negative emotions are often linked, and both can impact the reward circuit. The use of electroacupuncture (EA) has been found to regulate and improve these conditions. This study explores the potential mechanism of chronic pain relief by adding acupoints with emotional regulation effect to the basis of routine EA analgesia, to optimize the acupoint compatibility scheme of EA in the treatment of analgesia.

Method

For this study, 42 male Wistar rats were used. Recombinant adeno-associated viruses were used to label and regulate the activity of dopamine (DA) neurons. The rat model was established by complete Freund’s adjuvant (CFA). Lower limb electroacupuncture (LEA) was applied to the ST36 and BL60 acupoints. In addition, LEA + scalp EA (SEA) was given using the GV20 and GV24+ acupoints besides ST36 and BL60. To evaluate the pain threshold, we measured 50% paw withdrawal thresholds and thermal paw withdrawal latencies. Negative emotions were evaluated through the open field test, marble-burying test, sucrose preference test, and forced swimming test. Moreover, the conditional place preference test was conducted to measure the reward behavior in response to pain relief. Immunofluorescence staining, Western blotting, and qPCR were used to detect the activity of the VTADA-NAc reward circuit.

Result

The injection of CFA significantly lowered the pain threshold. As the pain persisted, the anxiety and depression-like behaviors escalated while the response to reward reduced. Meanwhile, the VTADA-NAc pathway was suppressed with pain chronification. However, activating DA neurons in VTA attenuated the effects induced by CFA. LEA could relieve chronic pain, negative emotions, and reward disorders, while also activating the VTADA-NAc pathway. In addition, LEA + SEA exhibited a more pronounced effect compared with LEA alone. Nevertheless, chemogenetic inhibition of DA neurons decreased the efficacy of LEA + SEA in the treatment of chronic pain and associated comorbidities.

Conclusion

Adding SEA to conventional LEA effectively alleviates negative emotions and chronic pain, potentially due to the activation of the VTADA-NAc reward neural circuit. Thus, LEA + SEA is a more effective treatment for hyperalgesia and associated negative emotions compared with LEA alone.
Case report: A case of fulminant type 1 diabetes mellitus after COVID-19 vaccination during treatment of advanced gastric cancer: pitfall in managing immune-related adverse events
Authors: Tanaka Toshimitsu , Nagasu Sachiko , Furuta Takuya , Gobaru Mizuki , Suzuki Hiroyuki , Shimotsuura Yasutaka , Akiba Jun , Nomura Masatoshi , Fujita Fumihiko , Kawaguchi Takumi , Miwa Keisuke
Published: December 2023

The occurrence of fulminant type 1 diabetes mellitus as an adverse event during cancer immunotherapy has been previously reported. However, little is known about the causal relationship between the coronavirus disease 2019 (COVID-19) vaccination and fulminant type 1 diabetes mellitus. A 60-year-old man with advanced gastric cancer, receiving S-1 + oxaliplatin and nivolumab therapy, followed by nab-paclitaxel + ramucirumab as a second-line treatment, with steroid supplementation for complications of hypopituitarism-induced hypoadrenocorticism, was administered a COVID-19 vaccine after three cycles of nab-paclitaxel + ramucirumab. Two days later, he developed severe malaise and anorexia, which required emergency admission to our hospital for suspected adrenal insufficiency. Despite increasing steroids, his general condition changed suddenly after 12 hours leading to his death. Histopathological analysis of autopsy samples revealed loss of the islets of Langerhans, indicating fulminant type 1 diabetes mellitus. We failed to recognize the onset of fulminant type 1 diabetes mellitus because its symptoms were similar to those of adrenal insufficiency. The number of reports on the onset of fulminant type 1 diabetes mellitus after COVID-19 vaccination has been increasing, and in this case, the onset occurred on the second day after COVID-19 vaccination, suggesting an association between vaccination and fulminant type 1 diabetes mellitus. Clinicians should be aware of the risk of fulminant type 1 diabetes mellitus, although rare, after COVID-19 vaccination.
A comparative study of elective nodal irradiation and involved field irradiation in elderly patients with advanced esophageal cancer
Authors: Dai Yuanfei , Huang Di , Zhao Wei , Wei Jie
Published: December 2023

Objective

This comparative study aimed to explore the feasibility of involved field irradiation (IFI) in the radiotherapy of elderly patients with advanced esophageal cancer, compared with elective nodal irradiation (ENI).

Methods

A total of 245 elderly patients (age ≥70 years) with advanced esophageal cancer, who received radiotherapy in our department from January 2014 to December 2020, were divided into the ENI group (n=111) and the IFI group (n=134). Clinical efficacy, toxicities, survival rates, treatment failures, and multifactorial survival analyses were conducted for both groups.

Results

The ENI group and the IFI group showed no significant differences in terms of short-term efficacy (91.9% vs 91.0%, P=0.814), 1-year overall survival (OS) (81.1% vs 74.6%, P=0.228), 2-year OS (22.5% vs 25.4%, P= 0.603), 1-year progression-free survival (PFS) (56.8% vs 51.5%, P= 0.198), 2-year PFS (8.1% vs 9.0%, P=0.814), regional failures (38.7% vs 31.3%, P=0.226), and distant metastasis (21.6% vs 14.9%, P=0.174). The median overall survival (OS) was 19 months in the ENI group and 18 months in the IFI group (Log-rankχ2 = 0.012, P=0.913). The median progression-free survival (PFS) was 13 months in the ENI group and 11 months in the IFI group (Log-rankχ2 = 1.834, P=0.176). There were no significant statistical differences in both OS and PFS (P>0.05). The incidence of grade ≥3 radiation pneumonia and grade ≥3 radiation esophagitis in the IFI group was 8.2% and 11.2%, respectively, which were significantly lower than those in the ENI group (17.1%, P=0.034; 21.6%, P=0.026). Univariate analysis revealed that age, gender, T stage, N stage, and synchronous chemotherapy were factors affecting prognosis. Multivariate analysis showed that age, gender, T stage, and synchronous chemotherapy were independent prognostic factors, with hazard ratios of 1.227, 1.466, 2.441, and 2.714, and P values of <0.001, 0.006, <0.001, and<0.001, respectively.

Conclusion

IFI is a suitable choice for elderly patients with advanced esophageal cancer, as it yields similar efficacy to ENI while reducing toxicities. Age, gender, T stage, and synchronous chemotherapy are independent prognostic factors for elderly patients with esophageal cancer.
Optimal planning target margin for prostate radiotherapy based on interfractional and intrafractional variability assessment during 1.5T MRI-guided radiotherapy
Authors: Kim Jina , Sung Jiwon , Lee Seo Jin , Cho Kang Su , Chung Byung Ha , Yang Dongjoon , Kim Jihun , Kim Jun Won
Published: December 2023

Introduction

We analyzed daily pre-treatment- (PRE) and real-time motion monitoring- (MM) MRI scans of patients receiving definitive prostate radiotherapy (RT) with 1.5 T MRI guidance to assess interfractional and intrafractional variability of the prostate and suggest optimal planning target volume (PTV) margin.

Materials and methods

Rigid registration between PRE-MRI and planning CT images based on the pelvic bone and prostate anatomy were performed. Interfractional setup margin (SM) and interobserver variability (IO) were assessed by comparing the centroid values of prostate contours delineated on PRE-MRIs. MM-MRIs were used for internal margin (IM) assessment, and PTV margin was calculated using the van Herk formula.

Results

We delineated 400 prostate contours on PRE-MRI images. SM was 0.57 ± 0.42, 2.45 ± 1.98, and 2.28 ± 2.08 mm in the left-right (LR), anterior-posterior (AP), and superior-inferior (SI) directions, respectively, after bone localization and 0.76 ± 0.57, 1.89 ± 1.60, and 2.02 ± 1.79 mm in the LR, AP, and SI directions, respectively, after prostate localization. IO was 1.06 ± 0.58, 2.32 ± 1.08, and 3.30 ± 1.85 mm in the LR, AP, and SI directions, respectively, after bone localization and 1.11 ± 0.55, 2.13 ± 1.07, and 3.53 ± 1.65 mm in the LR, AP, and SI directions, respectively, after prostate localization. Average IM was 2.12 ± 0.86, 2.24 ± 1.07, and 2.84 ± 0.88 mm in the LR, AP, and SI directions, respectively. Calculated PTV margin was 2.21, 5.16, and 5.40 mm in the LR, AP, and SI directions, respectively.

Conclusions

Movements in the SI direction were the largest source of variability in definitive prostate RT, and interobserver variability was a non-negligible source of margin. The optimal PTV margin should also consider the internal margin.
Rankine-Hugoniot relations in turbulent shocks
Authors: Gedalin Michael
Published: December 2023

A collisionless shock is often regarded as a discontinuity with a plasma flow across it. Plasma parameters before the shock (upstream) and behind the shock (downstream) are related by the Rankine-Hugoniot relations (RH) which essentially are the mass, momentum, and energy conservation laws. Standard RH assume the upstream and downstream regions are uniform, that is, the fluctuations of the plasma parameters and magnetic field are negligible. Observations show that there exist shocks in which these fluctuations remain large well behind the shock. The pressure and energy of these fluctuations have to be included in the total pressure and energy. Here we lay down a basis of theory taking into account persisting non-negligible turbulence. The theory is applied to the case where only downstream magnetic turbulence is substantial. It is shown that the density and magnetic field compression ratios may significantly deviate from those predicted by the standard RH. Thus, turbulent effects should be taken into account in observational data analyses.
Testing effects of vapor pressure deficit on fruit growth: a comparative approach using peach, mango, olive, orange, and loquat
Authors: Carella Alessandro , Massenti Roberto , Lo Bianco Riccardo
Published: December 2023

Determining the influence of vapor pressure deficit (VPD) on fruit growth is a key issue under a changing climate scenario. Using a comparative approach across different fruit tree species may provide solid indications of common or contrasting plant responses to environmental factors. Knowing fruit growth responses to VPD may also be useful to optimize horticultural management practices under specific atmospheric conditions. Climate data to calculate VPD and fruit relative growth rates (RGR) by fruit gauges were monitored in peach at cell division, pit hardening and cell expansion stages; in two mango cultivars at cell division, cell expansion and maturation stages; in two olive cultivars, either full irrigated or rainfed, at early and late cell expansion stages; in ‘Valencia’ orange at early and late cell division stage, before and after mature fruit harvest; in loquat at cell expansion and maturation stages. At the fruit cell division stage, sensitivity of fruit growth to VPD seems to vary with species, time, and probably soil and atmospheric water deficit. ‘Keitt’ mango and ‘Valencia’ orange fruit growth responded to VPD in opposite ways, and this could be due to very different time of the year and VPD levels in the monitoring periods of the two species. At pit hardening stage of peach fruit growth, a relatively weak relationship was observed between VPD and RGR, and this is not surprising as fruit growth in size at this stage slows down significantly. A consistent and marked negative relationship between VPD and RGR was observed at cell expansion stage, when fruit growth is directly depending on water intake driving cell turgor. Another behavior common to all observed species was the gradual loss of relationship between VPD and RGR at the onset of fruit maturation, when fruit growth in size is generally programmed to stop. Finally, regardless of fruit type, VPD may have a significant effect on fruit growth and could be a useful parameter to be monitored for tree water management mainly when the cell expansion process prevails during fruit growth.
Human involvement in autonomous decision-making systems. Lessons learned from three case studies in aviation, social care and road vehicles
Authors: Salvini Pericle , Reinmund Tyler , Hardin Benjamin , Grieman Keri , Ten Holter Carolyn , Johnson Aaron , Kunze Lars , Winfield Alan , Jirotka Marina
Published: December 2023

This paper draws on three case studies to examine some of the challenges and tensions involved in the use of Autonomous Decision-Making Systems (ADMS). In particular, the paper highlights: (i) challenges around the shifting “locale” of the decision, and the associated consequences for stakeholders; (ii) potential implications for stakeholders from regulation such as the General Data Protection Regulation (GDPR); (iii) the different values that stakeholder groups bring to the “decision” question; (iv) how complex pre-existing webs of stakeholders and decision-making authorities may be disrupted or disempowered by the use of an automated system and the lack of evaluation of possible consequences; (v) how ADMS for non-technical users can lead to circumvention of the boundaries of intended system use. We illustrate these challenges through case studies in three domains: adult social care, aviation, and vehicle driver monitoring systems. The paper closes with recommendations for both practice and policy in the deployment of ADMS.
Gender differences in vitiligo: psychological symptoms and quality of life assessment description
Authors: Samela Tonia , Malorni Walter , Matarrese Paola , Mattia Gianfranco , Alfani Stefania , Abeni Damiano
Published: December 2023

Objective

Assuming that the difference exist in the manifestation of psychological suffering among genders, the purpose of this review is to summarize the current knowledge on gender differences in vitiligo quality of life and psychological assessment.

Methods

We searched in PubMed, Scopus, and Web of Science databases for original articles in English language. Results were screened according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA checklist).

Results

The study yielded 107 results; 12 articles have been evaluated as eligible. Each eligible study has been screened and analyzed. The study’s qualitative evaluation revealed that 8 papers were classifiable as satisfactory, 4 were classifiable as unsatisfactory. The agreement between the coders was high (% agreement = 84.6%; Cohen’s kappa = 0.79). All considered researches (100%) were cross-sectional studies, based on self-report questionnaires. From our analysis, women with vitiligo had a higher risk to experience lower quality of life, and worse mental health in a wide range of psychopathology symptoms than men. A wide heterogeneity of tools is used to investigate the quality of life and psychological symptoms among these patients.

Conclusion

Unfortunately, there are few explanatory models proposed in the literature to rationalize these findings. It will be important to investigate in further researches the specific influence of known risk factors for psychopathology in this population to better explore these phenomena.
Hypnosis measured with monitors of anesthetic depth – EEG changes during the test for Harvard Group Scale of Hypnotic Susceptibility
Authors: Zech Nina , Seemann Milena , Hansen Ernil
Published: December 2023

Introduction

Hypnotic trance can be defined as a non-ordinary state of consciousness that is accompanied by a number of neurophysiological changes, including brain electrophysiology. In addition to subjective measures, corresponding objective parameters are needed in experimental and clinical hypnosis research but are complex, impractical, or unspecific. A similar challenge exists for the measurement and monitoring of drug-induced hypnosis, namely general anesthesia. The observation of changes in EEG induced by narcotics has led to the development of monitors for the depth of anesthesia based on EEG parameters. We investigated whether two such monitors react to the induction and maintenance of hypnosis during a highly standardized procedure.

Methods

A total of 56 volunteers were monitored for the bispectral index (BIS) and cerebral state index (CSI) (range 0–100, >95 considered “awake”) during the Harvard Group Scale of Hypnotic Susceptibility test. For this test, trance is induced by a taped text and followed by 12 tasks performed under hypnosis. In contrast to random forms of hypnosis, this represents a standardized, worldwide-established condition. According to the resulting score, participants were classified into suggestibility groups in order to evaluate whether the electrophysiological measurements of BIS and CIS indices differ between high and low suggestible persons. Furthermore, participants were asked to rate their hypnotic depth (HD, 1–10) at every task of the test.

Results

Scores dropped significantly from a mean of 97.7 to 86.4 for BIS and from 94.6 to 77.7 for CSI with the induction of hypnosis to stay throughout hypnosis at levels of approximately 88.6 or 82.9, respectively. Results did not differ between high- and low-suggestible participants. The means of the subjective score of hypnotic depth and of the electrophysiological measurements showed a similar course. However, no correlation was found between BIS or CSI values and scores of hypnotic depths.

Conclusion

Monitors for depth of anesthesia respond to changes in consciousness, including trance states of hypnosis. However, specificity is unclear. Practically, in hypnosis research with the exclusion of drug effects or sleep, these monitors might be helpful to test and compare the efficacy of induction texts and to detect disturbances of trance state.
The relationship between trait mindfulness and inclusive education attitudes of primary school teachers: a multiple mediating model
Authors: Huang Fenxia
Published: December 2023

Objective

This study aims to explore the impact of primary school teachers’ empathy and efficacy for inclusive practice on the relationship between trait mindfulness and inclusive educational attitudes.

Methods

A total of 606 primary school teachers were tested using the Five Facet Mindfulness Questionnaire, Interpersonal Response Index Scale, Teacher Self-efficacy for Inclusive Practice Scale, and Teachers’ Multidimensional Attitudes toward Inclusive Education Scale.

Results

Primary school teachers’ trait mindfulness is significantly positively correlated with inclusive educational attitudes. Primary school teachers’ trait mindfulness has an indirect impact on inclusive education attitudes through empathy, and primary school teachers’ trait mindfulness has an indirect impact on inclusive education attitudes through teacher efficacy for inclusive practice. In addition, empathy and teacher efficacy for inclusive practice play a sequential mediating role between primary school teachers’ trait mindfulness and inclusive education attitudes.

Conclusion

This empirical study reveals that empathy and efficacy for inclusive practice play a sequential mediating role between primary school teachers’ trait mindfulness and inclusive education attitudes. On one hand, this research contributes to enriching the outcomes in the field of inclusive education for primary school teachers, providing a theoretical foundation for the study of their inclusive education attitudes. On the other hand, the study offers a detailed explanation of the psychological mechanisms behind the impact of mindfulness traits on the inclusive education attitude of primary school teachers, guiding schools in implementing mindfulness-based intervention programs.
Organizational compassion and employee adversarial growth under various job control
Authors: Nie Ting , Zhao Xinqiang , Zheng Yanying
Published: December 2023

Introduction

Adversity can bring stress and challenges to an individual's life, but many people who experience adversity also have positive changes. The formative mechanisms of individual adversarial growth have received widespread attention.

Methods

A two-wave survey of 421 Chinese employees who experienced adversity during the COVID-19 epidemic was used to examine the influence mechanism of organizational compassion on adversarial growth and the moderating effect of job control.

Results

Through correlation analysis, hierarchical regression, and bootstrap test on the cross-sectional data, the study has verified organizational compassion, work passion, self-worth, and adversarial growth form a chain mediating relation. Job control negatively moderates the indirect effect of organizational compassion on adversarial growth through work passion and self-worth, that is, the positive effect of organizational compassion on employee adversarial growth through work passion and self-worth is more pronounced under lower job control.

Discussion

Organizational compassion can increase employee adversarial growth by enhancing their work passion and self-worth. Organizations should also pay more attention to those employees with lower job control who are in adversity, they are more likely to benefit from the organization's care and compassion.
Global systematic review of occupational health and safety outcomes among sanitation and hygiene workers
Authors: Tolera Sina Temesgen , Temesgen Shibiru , Mulat Endalew Salie , Alamirew Tamagnu Sintie , Temesgen Liku Muche
Published: December 2023

Introduction

Sanitary workers are exposed to a variety of occupational hazards in a variety of working environments, which can result in occupational-related outcomes. As a result, the goal of this review was to identify occupational health and safety outcomes among sanitary workers worldwide.

Methods

PRISMA was used as flow diagram and PICOS was used review questions. The studies published in English were searched from databases and others methods ranging from 2000 to 2022. Boolean logic (AND, OR), MeSH, and keywords used: (Occupation *OR Job *OR Work) AND (Occupational related respiratory Symptoms *OR Disease) AND [Solid waste collectors (SWCs) *OR Street sweepers (SS) *OR Sewage workers and waste treatment (STWs)] AND (Countries).

Results

A total of 228 studies were identified from 23 countries across the world. Studies were found via PubMed (n = 40), Medline (n = 25), Embase (n = 11) and Global Health (n = 66) and Google scholar (n = 63) and from previous (n = 23). From 8,962 of eligible sanitary workers, about 4,742 (54%), 1714 (19%) and 1,441 (16%) were sewage, sweepers and solid waste workers, respectively. A total study (n = 51) were eligible for occupational health and safety outcomes. Of these, respiratory problems accounted 27 (52%) and Gastroenteritis 14 (27%).

Conclusion

Despite a large number of studies to date provides sanitary employees all over the world face occupational-related risks, hence more research is needed to enhance and quantify illness burden among sanitary workers.
Threat or opportunity? An analysis of perceptions of cultured meat in the UK farming sector
Authors: Manning Louise , Dooley John J. , Dunsford Illtud , Goodman Michael K. , MacMillan Tom C. , Morgans Lisa C. , Rose David C. , Sexton Alexandra E.
Published: December 2023

Background

The environmental and social impacts of cultured meat, and its economic viability, are contingent on its implications for food production and for agriculture. However, the implications of cultured meat production for farmers have not yet been thoroughly investigated and are poorly understood. The aim of this research was to engage with the farming sector in critically assessing cultured meat as a technology which could profoundly affect future farm livelihoods, land use, rural and farming communities and agricultural value chains. Ensuring farmers’ voices, and potential ‘counter-narratives’ inform the development of cultured meat is not only inclusive, but could identify unexpected impacts of this emerging technology and contribute to the framing of the social license of the industry developing them.

Methods

Six focus groups were undertaken with 75 UK farmers from a variety of farming sectors and regions. Questions focused on what the term ‘cultured meat’ means to farmers, the potential impacts of cultured meat, and potential business scenarios arising for farmers. All meetings were recorded, transcribed, and thematically analyzed.

Results and discussion

Farmers expressed complex and considered reflections on cultured meat, raising several perceived opportunities and risks associated with the themes of ‘ethics and affective’ narratives, ‘environment-based’ narratives, and ‘socio-economic’ narratives. Aspects of foci of power, food system control and transparency associated with cultured meat emerged from the conversations, as well as cultured meat’s potential impacts on the environment and on jobs, farming/rural communities and connecting with the land.

Conclusion

Globally, meat production underpins the livelihoods of many rural communities, so a transition to cultured meat is likely to have deep-seated ethical, environmental, and socio-economic impacts. Within the discourse on cultured meat the voices of farmers are often lost. While not claiming to be representative of all UK farming, this study engaged UK farmer perspectives as a way of starting the substantive process of greater stakeholder inclusion in cultured meat innovation pathways, and which should underpin responsible technology transitions in agriculture.
Sustainability of one-time seed distributions: a long-term follow-up of vegetable seed kits in Tanzania
Authors: Wanyama Rosina , Mvungi Henry , Luoga Ritha , Mmasi Maria , Zablon Ernest , N’Danikou Sognigbe , Schreinemachers Pepijn
Published: December 2023

The one-time distribution of vegetable seed kits containing small (2 grams) samples of improved varieties of traditional and exotic vegetables can potentially increase vegetable production and consumption among poor rural households, but evidence is lacking. This study therefore analyzed the extent to which recipients of vegetable seed kits in Tanzania have sustained the use of introduced vegetable varieties. Data came from a random sample of 796 households who directly or indirectly received seed kits between 2012 and 2018, complemented with 10 focus group discussions among seed kit recipients. The results show that 24% of direct recipients are still reproducing the seed of introduced vegetable varieties after a period of 5–10 years, with variation across varieties and the time seed was introduced. The success rate was higher for traditional vegetables than exotic vegetables and higher for women than men. Reasons for not continuing seed use were the lack of knowledge on seed saving, problems with pests and diseases, and reduced germination. Hence, the sustainability of small seed kit distributions can be enhanced by accompanying them with adequate training on seed saving and seed storage.
Therapeutic update on oral potassium exchange resin use in chronic kidney disease patients: a systematic review of randomized controlled clinical trials
Authors: Gruver Jaclyn , Al-Makki Akram , Shepler Brian
Published: December 2023

Hyperkalemia is a common electrolyte disorder in patients with chronic kidney disease (CKD) that increases in prevalence with the decline of glomerular fltration rate (GFR). Another risk of hyperkalemia is the use of renin-angiotensin-aldosterone system inhibitors (RAASi) and/or mineralocorticoid receptor antagonists (MRAs) in managing CKD and proteinuria. The treatment of chronic hyperkalemia is challenging especially for outpatients. Treatment options for hyperkalemia include the potassium exchange resins of which two new potassium binders, Patiromer Sorbitex Calcium, and Sodium Zirconium Cyclosilicate (SZC) have demonstrated their clinical efficacy in reducing serum potassium with a positive safety profile. The old potassium exchange resin sodium polystyrene sulfonate (Kayexalate™) has some negative side effects including colonic necrosis, hypomagnesemia, and hypernatremia. In this review and literature search, we compare the available oral potassium exchange resins, highlight their advantages and disadvantages and comment on efficacy and safety parameters specifically in CKD patients.
A Deep Neural Networks-Based Sound Speed Reconstruction with Enhanced Generalization by Training on a Natural Image Dataset
Authors: Watanabe Yoshiki , Azuma Takashi , Takagi Shu
Published: December 2023

Sound speed reconstruction has been investigated for quantitative evaluation of tissue properties in breast examination. Full waveform inversion (FWI), a mainstream method for conventional sound speed reconstruction, is an iterative method that includes numerical simulation of wave propagation, resulting in high computational cost. In contrast, high-speed reconstruction of sound speed using a deep neural network (DNN) has been proposed in recent years. Although the generalization performance is highly dependent on the training data, how to generate data for sufficient generalization performance is still unclear. In this study, the quality and generalization performance of DNN-based sound speed reconstruction with a ring array transducer were evaluated on a natural image-derived dataset and a breast phantom dataset. The DNN trained on breast phantom data (BP-DNN) could not reconstruct the structures on natural image data with diverse structures. On the other hand, the DNN trained on natural image data (NI-DNN) successfully reconstructed the structures on both natural image and breast phantom test data. Furthermore, the NI-DNN successfully reconstructed tumour structures in the breast, while the BP-DNN overlooked them. From these results, it was demonstrated that natural image data enables DNNs to learn sound speed reconstruction with high generalization performance and high resolution.
Multi-Disciplinary Care of Hilar Cholangiocarcinoma: Review of Guidelines and Recent Advancements
Authors: Padmanaban Vennila , Ruff Samantha M. , Pawlik Timothy M.
Published: December 2023

Cholangiocarcinoma (CCA) is a rare malignancy of the intrahepatic and extrahepatic biliary ducts. CCA is primarily defined by its anatomic location: intrahepatic cholangiocarcinoma versus extrahepatic cholangiocarcinoma. Hilar cholangiocarcinoma (HC) is a subtype of extrahepatic cholangiocarcinoma that arises from the common hepatic bile duct and can extend to the right and/or left hepatic bile ducts. Upfront surgery with adjuvant capecitabine is the standard of care for patients who present with early disease and the only curative therapy. Unfortunately, most patients present with locally advanced or metastatic disease and must rely on systemic therapy as their primary treatment. However, even with current systemic therapy, survival is still poor. As such, research is focused on developing targeted therapies and multimodal strategies to improve overall prognosis. This review discusses the work-up and management of HC focused on the most up-to-date literature and ongoing clinical trials.
Selective RET Inhibitors (SRIs) in Cancer: A Journey from Multi-Kinase Inhibitors to the Next Generation of SRIs
Authors: Clark Liz , Fisher Geoff , Brook Sue , Patel Sital , Arkenau Hendrik-Tobias
Published: December 2023

RET is a receptor tyrosine kinase that plays an important role in the development of neurons and kidneys. The gene encoding the rearranged-during-transfection (RET) receptor tyrosine kinase was first discovered in the 1980s. Activating RET mutations and rearrangements have since been identified as actionable drivers of oncogenesis in numerous cancer types and are most prevalent in thyroid and non-small-cell lung cancer. Following the modest success of repurposed RET-active multikinase inhibitors, the first selective RET inhibitors (SRIs), selpercatinib and pralsetinib, received regulatory approval in 2020. Now, thousands of patients with RET-altered cancers have benefited from first-generation SRIs, with impressive deep and durable responses. However, following prolonged treatment with these SRIs, a number of acquired on-target resistance mutations have been identified together with other non-RET-dependent resistance mechanisms. Today, the focus is on how we can further evolve and improve the treatment of RET-altered tumors with next-generation SRIs, and a number of candidate drugs are in development. The ideal next-generation SRIs will be active against on-target acquired resistance alterations, including those that emerge in the CNS, and will have improved safety and tolerability relative to first-generation SRIs. In this review, we will provide an update on these candidates and their potential to meet the unmet clinical need for patients who progress on first-generation SRIs.
Role of c-Src in Carcinogenesis and Drug Resistance
Authors: Raji Lukmon , Tetteh Angelina , Amin A. R. M. Ruhul
Published: December 2023

The aberrant transformation of normal cells into cancer cells, known as carcinogenesis, is a complex process involving numerous genetic and molecular alterations in response to innate and environmental stimuli. The Src family kinases (SFK) are key components of signaling pathways implicated in carcinogenesis, with c-Src and its oncogenic counterpart v-Src often playing a significant role. The discovery of c-Src represents a compelling narrative highlighting groundbreaking discoveries and valuable insights into the molecular mechanisms underlying carcinogenesis. Upon oncogenic activation, c-Src activates multiple downstream signaling pathways, including the PI3K-AKT pathway, the Ras-MAPK pathway, the JAK-STAT3 pathway, and the FAK/Paxillin pathway, which are important for cell proliferation, survival, migration, invasion, metastasis, and drug resistance. In this review, we delve into the discovery of c-Src and v-Src, the structure of c-Src, and the molecular mechanisms that activate c-Src. We also focus on the various signaling pathways that c-Src employs to promote oncogenesis and resistance to chemotherapy drugs as well as molecularly targeted agents.
Sunitinib Treatment of VHL C162F Cells Slows Down Proliferation and Healing Ability via Downregulation of ZHX2 and Confers a Mesenchymal Phenotype
Authors: Buart Stéphanie , Diop M’boyba Khadija , Damei Isabelle , Chouaib Salem
Published: December 2023

von Hippel-Lindau (VHL) disease, due to mutations of the tumor suppressor VHL gene, is a rare hereditary syndrome with a high risk of developing clear cell renal cell carcinoma (ccRCC). We asked whether the VHL-C162F mutation interferes with proliferation, migration, healing and forming colony ability by using wild-type VHL (WT VHL) and VHL-C162F reconstituted cells. We then analyzed the in vitro impact of the sunitinib treatment on VHL-C162F cells. We showed that VHL-C162F mutations have no impact on cell morphology, colony formation and migration ability but confer a significant higher healing ability than in WT VHL cells. RNA sequencing analysis revealed that VHL-C162F mutation upregulates genes involved in hypoxia and epithelial mesenchymal transition (EMT) pathways by comparison with VHL WT cells. We next showed a decrease in healing ability in VHL-C162F cells depleting on ZHX2, an oncogenic driver of ccRCC, highlighting the potential involvement of ZHX2 in aggressiveness of the VHL-C162F cells. Moreover, we found that sunitinib treatment inhibits ZHX2 expression and induces a reduced proliferation correlating with downregulation of P-ERK. Sunitinib treatment also conferred a more mesenchymal profile to VHL-C162F cells with significant downregulation of E-cadherin and upregulation of N-cadherin, Slug and AXL. Sunitinib therapy may therefore promote disease progression in VHL-C162F patients.
Validation of the “Rome” Classification for Squamous Cell Carcinoma of the Nasal Vestibule
Authors: Scheurleer Willem Frederik Julius , de Ridder Mischa , Tagliaferri Luca , Crescio Claudia , Parrilla Claudio , Mattiucci Gian Carlo , Fionda Bruno , Deganello Alberto , Galli Jacopo , de Bree Remco , Rijken Johannes A. , Bussu Francesco
Published: December 2023

Squamous cell carcinoma of the nasal vestibule is considered a rare malignancy that differs from other sinonasal malignancies in many respects. Four staging systems currently exist for this disease, the most recent addition being the “Rome” classification. This study assesses the use of this new classification and its prognostic value regarding various outcome measures. A retrospective multicenter cohort study of patients with a primary squamous cell carcinoma of the nasal vestibule who were treated in three tertiary head and neck oncology referral centers was conducted. A total of 149 patients were included. The median follow-up duration was 27 months. Five-year locoregional control (LRC), disease-specific survival (DSS), and overall survival (OS) were 81.6%, 90.1, and 62.5% respectively. A statistically significant association was observed between the Rome classification and all survival outcomes in both univariable and multivariable analyses. Moreover, it appeared to perform better than the Union for International Cancer Control TNM classification for tumors of the nasal cavity and paranasal sinuses. The new Rome classification can be used effectively and is associated with LRC, DSS, and OS. However, it requires further validation in a larger (prospective) study population.
Anti-Prokineticin1 Suppresses Liver Metastatic Tumors in a Mouse Model of Colorectal Cancer with Liver Metastasis
Authors: Kono Hiroko , Goi Takanori , Matsunaka Takayuki , Koneri Kenji
Published: December 2023

Multidisciplinary treatment for colorectal cancer (CRC) has undergone significant advances, and molecularly targeted drugs have substantially improved patient prognosis. However, one problem with current molecularly targeted therapeutics is that they must be used in combination with anticancer agents. New molecular targeted therapies that can be used alone are needed. We have previously identified prokineticin1 (PROK1) factor as a therapeutic potential target for CRC. PROK1 factor is involved in the angiogenesis of tissues surrounding CRC tumors. Additionally, PROK1 receptors 1 and 2 are expressed in CRC cell lines, playing roles in cell proliferation via an autocrine mechanism and in the signaling system. In this study, a liver metastasis mouse model was developed using human colorectal cancer cell lines, and mice were divided into anti-PROK1 antibody administration and control groups. Mice were treated intraperitoneally with antibodies or phosphate-buffered saline (control) every three days. The number, size, and cell proliferation ability of metastatic lesions were analyzed. Our results suggested that the number, size, and cancer cell proliferation ability of metastatic lesions decreased, and the survival time significantly increased in the antibody-treated group compared to those in the control group. Thus, the anti-PROK1 antibody therapy suppressed the cell proliferation ability of liver metastatic lesions in a CRC mouse model, suggesting its potential as a novel treatment strategy.