bluuebunny/crossref_metadata_2025 huggingface dataset:
Geography Far from Equilibrium
Authors: Pumain Denise
Published: January 2017

Geography makes little use of the concept of equilibrium. Unlike economics, geographical inquiry is based on the recognition of differences and asymmetries among regions and civilisations. In this it does not refer to general mechanisms that would be equivalent to the market for fixing prices and equilibrating supply and demand. Early geographers searched for explanations to the great variety of landscapes and ways of life that were observed all over the planet. Modern geographers study both the ‘vertical’ interactions between societies and their local milieu and the ‘horizontal’ interactions between cities and regions. This involves two opposing causes of territorial inequalities, spatial diffusion of innovation and urban transition. Whereas diffusion of innovation alone might result in homogeneity, combined with the dynamics of city formation the result is increasing heterogeneity and inequality. The phenomenon of increasing returns with city size is explained by higher population densities and connections multiplying the probability of productive interactions, as well as by adaptive valuation of accumulated assets. While there may be great wealth, in some large urban agglomerations large informal settlements of slums and shanties are still expanding. Global societal evolution is an open process with no fixed asymptotic point in the future: there is no final equilibrium state to reach for the world. Open evolution may hamper the quality of predictions that can be made about the future, but geographical knowledge of past dynamics may help to make forecasts more certain. Powerful analytical tools have been developed in the last five or six decades that greatly improve the quality of geographical work and its ability to provide stakeholders and decision makers with clearer insights for exploring possible territorial futures. Geographical Information Systems are now universally used in all kind of administrations dealing with localised services. Detailed geographical information from many data sources enables a shift from a macro-static view to a micro-macro dynamical view that is necessary for management and planning policies in a non-linear world. As a science geography remains deliberately far from equilibrium.
Facelift Approach for Resecting Benign Upper Neck Masses
Authors: Park Jun‐Ook
Published: January 2017

Background

This study evaluated the feasibility of non‐magnified resection of various benign lesions of the upper neck using the facelift incision without endoscopic equipment to establish indications for the procedure.

Methods

This retrospective analysis examined 86 patients who underwent surgery for upper neck masses using the facelift incision or conventional transcervical incision at our institute between January 2012 and December 2015.

Results

We performed 41 operations using facelift incisions (facelift group) and 45 using conventional horizontal incisions (conventional group). All 86 operations were successful. In the facelift group, no patient needed conversion to conventional open resection and no patient required the use of an endoscopic device due to a limited surgical view for safe resection. There were no major surgical complications in either group. Transient sensory changes in the auricle occurred in 26% of the patients in the facelift group, but all patients recovered within 2 months. In all patients in the facelift group, the scars were invisible as they were covered by the auricle and hair, while the surgical scars were noticeable in 91% (41/45) of the patients in the conventional group when they were wearing standard shirts (p < 0.001) at 3–4 weeks after surgery.

Conclusions

The facelift approach provides a short direct route to upper neck masses, and it enables an adequate workspace not only for endoscopic or robotic surgery, but also for open surgery with the naked eye. The surgical indications for the facelift incision include the removal of most benign tumors occurring in the upper neck at levels II and III.
Is Unilateral Neck Surgery Feasible in Patients with Sporadic Primary Hyperparathyroidism and Double Negative Localisation?
Authors: Scott‐Coombes D. M. , Rees J. , Jones G. , Stechman M. J.
Published: January 2017

Introduction

Ultrasound and Tc99mMIBI scans are used to localise parathyroid tumours in sporadic primary hyperparathyroidism (pHPT). Intra‐operative PTH (ioPTH) assay facilitates unilateral neck exploration (UNE). When both ultrasound and MIBI are negative, it is our policy to explore the left side of the neck and only proceed to bilateral neck exploration (BNE) when either a tumour is not found or when ioPTH does not fall to >50% of the highest pre‐excision value. The aim of this study was to investigate the outcome of our approach to ‘double negative’ patients.

Methods

A retrospective analysis of patients undergoing primary parathyroidectomy for pHPT. Data were obtained from a prospective surgical database and the hospital electronic patient record.

Results

Between January 2004 and November 2014, 746 patients underwent a parathyroidectomy for pHPT. Those who did not have both pre‐operative scans, ioPTH or a minimum of 6‐month follow‐up were excluded. Of 552 patients, 111 (20%) had double negative scans (group A), and in 441, either one or both scans were positive (group B). Median age was 61.5 years (range 10–88). Pre‐operative PTH level was significantly lower in group A: 11.8 pmol/l (range 3.1–38.8) versus 14.9 pmol/l (range 2.8–101.6; P < 0.01). Median tumour weight was significantly lower in group A: 280 mg (range 50–3710) versus 573 mg (range 10–12,000; P < 0.01). Overall rate of multiple gland disease (MGD) was 11%; 24% in group A and 7% in group B (P < 0.01). Overall rate of UNE in Group A was 28% and converse to the rate in Group B (76%; P < 0.01). Sensitivity and specificity of ioPTH to detect MGD were 98 and 98% in Group A versus 98 and 100% in Group B. First‐time cure rate was 92.7% in group A and 96.8% in group B (P < 0.05).

Conclusion

A double negative scan is associated with small tumours and higher rates of MGD. Despite these challenges, surgery is successful in this group of patients reinforcing the message that negative localisation is not a contraindication for parathyroidectomy. We demonstrated that it is feasible to offer unilateral neck surgery to 28% of patients with double negative scans. A randomised trial is needed to compare BNE with ioPTH/UNE in this select population.
Alzheimer's biomarkers in daily practice (ABIDE) project: Rationale and design
Authors: de Wilde Arno , van Maurik Ingrid S. , Kunneman Marleen , Bouwman Femke , Zwan Marissa , Willemse Eline A.J. , Biessels Geert Jan , Minkman Mirella , Pel Ruth , Schoonenboom Niki S.M. , Smets Ellen M.A. , Wattjes Mike P. , Barkhof Frederik , Stephens Andrew , van Lier Erik J. , Batrla‐Utermann Richard , Scheltens Philip , Teunissen Charlotte E. , van Berckel Bart N.M. , van der Flier Wiesje M.
Published: January 2017

Introduction

The Alzheimer's biomarkers in daily practice (ABIDE) project is designed to translate knowledge on diagnostic tests (magnetic resonance imaging [MRI], cerebrospinal fluid [CSF], and amyloid positron emission tomography [PET]) to daily clinical practice with a focus on mild cognitive impairment (MCI)

Methods

ABIDE is a 3‐year project with a multifaceted design and is structured into interconnected substudies using both quantitative and qualitative research methods.

Results

Based on retrospective data, we develop personalized risk estimates for MCI patients. Prospectively, we collect MRI and CSF data from 200 patients from local memory clinics and amyloid PET from 500 patients in a tertiary setting, to optimize application of these tests in daily practice. Furthermore, ABIDE will develop strategies for optimal patient‐clinician conversations.

Discussion

Ultimately, this will result in a set of practical tools for clinicians to support the choice of diagnostic tests and facilitate the interpretation and communication of their results.
Constrained Politics: Labour Market Actors, Political Parties and Swedish Labour Immigration Policy
Authors: Boräng Frida , Cerna Lucie
Published: January 2017

Sweden used to be one of the most restrictive countries in the Organisation of Economic Development and Cooperation (OECD) in terms of labour immigration policy. This was drastically changed in 2008 when a very liberal immigration law was passed. Why did one of the most restrictive labour immigration countries suddenly become one of the most liberal ones? The article argues that it is necessary to consider labour market institutions and their consequences for labour migration. These factors will influence the preferences, strategies and chances of success for various policy actors. A decline in union power and corporatism in Sweden had important consequences for its labour immigration. Following this decline, employers and centre-right parties became more active and adopted more liberal policy positions than previously. The article analyses policy developments since the 1960s and draws on official documents, position statements, party manifestos, media coverage and original elite interviews.
Impact of ultra-viscous drops: air-film gliding and extreme wetting
Authors: Langley K. , Li E. Q. , Thoroddsen S. T.
Published: January 2017

A drop impacting on a solid surface must push away the intervening gas layer before making contact. This entails a large lubricating air pressure which can deform the bottom of the drop, thus entrapping a bubble under its centre. For a millimetric water drop, the viscous-dominated flow in the thin air layer counteracts the inertia of the drop liquid. For highly viscous drops the viscous stresses within the liquid also affect the interplay between the drop and the gas. Here the drop also forms a central dimple, but its outer edge is surrounded by an extended thin air film, without contacting the solid. This is in sharp contrast with impacts of lower-viscosity drops where a kink in the drop surface forms at the edge of the central disc and makes a circular contact with the solid. Larger drop viscosities make the central air dimple thinner. The thin outer air film subsequently ruptures at numerous random locations around the periphery, when it reaches below 150 nm thickness. This thickness we measure using high-speed two-colour interferometry. The wetted circular contacts expand rapidly, at orders of magnitude larger velocities than would be predicted by a capillary–viscous balance. The spreading velocity of the wetting spots is ${\sim}0.4~\text{m}~\text{s}^{-1}$ independent of the liquid viscosity. This may suggest enhanced slip of the contact line, assisted by rarefied-gas effects, or van der Waals forces in what we call extreme wetting. Myriads of micro-bubbles are captured between the local wetting spots.
AMERICA, ISLAM, AND CONSTITUTIONALISM: MUSLIM AMERICAN POVERTY AND THE MOUNTING POLICE STATE
Authors: Beydoun Khaled A.
Published: January 2017

Intersectionality alone cannot bring invisible bodies into view. Mere words won't change the way that some people—the less-visible members of political constituencies—must continue to wait for leaders, decision-makers and others to see their struggles.

—Kimberlé Crenshaw1

Hamtramck is a city that occupies many intersections. Geographically, it is approximately two square miles, swallowed entirely by the city of Detroit. Racially and religiously, Hamtramck is at the latter end of a pivotal crossroads. The city of roughly 22,000 people was once a concentrated and celebrated Polish enclave, a coveted destination for immigrants from the Eastern European nation seeking safe haven and economic opportunity. Today, a declining number of Polish businesses, and a statue of Pope John Paul II on the corner of Joseph Campau and Belmont Streets, commemorating his 1987 visit, symbolize the city's proud Polish and Catholic heritage.2 Taking in the sights and sounds of the city today quickly reveals that Hamtramck, however, is no longer predominantly Polish, but rather a destination and hub for Muslims pursuing the American Dream while heavily steeped in their native traditions.
Measurement of snow particle size and velocity in avalanche powder clouds
Authors: ITO YOICHI , NAAIM-BOUVET FLORENCE , NISHIMURA KOUICHI , BELLOT HERVÉ , THIBERT EMMANUEL , RAVANAT XAVIER , FONTAINE FIRMIN
Published: January 2017

Particle size, particle speed and airflow speed have been measured in the powder snow clouds of avalanches to investigate the suspension and transportation processes of snow particles. The avalanches were artificially triggered at the Lautaret full-scale avalanche test-site (French Alps) where an ultrasonic anemometer and a snow particle counter were setup in an avalanche track for measurements. Relatively large particles were observed during passage of the avalanche head and then the size of the particles slightly decreased as the core of the avalanche passed the measurement station. The particle size distribution was well fitted by a gamma distribution function. A condition for suspension of particles within the cloud based on the ratio of vertical velocity fluctuation to particle settling velocity suggests that the large particles near the avalanche head are not lifted up by turbulent diffusion, but rather ejected by a process involving collisions between the avalanche flow and the rough snow surface. Particle speeds were lower than the airflow speed when large particles were present in the powder cloud.
Slight glacier mass loss in the Karakoram region during the 1970s to 2000 revealed by KH-9 images and SRTM DEM
Authors: ZHOU YUSHAN , LI ZHIWEI , LI JIA
Published: January 2017

An anomalously slight glacier mass gain during 2000 to the 2010s has recently been reported in the Karakoram region. However, to date, no investigations of the region-wide glacier mass balance in the Karakoram prior to 2000 have been reported, leaving a knowledge gap for assessing glacier responses to climate change. We calculated elevation and mass change using DEMs generated from KH-9 images acquired during 1973–1980 and the 1 arc-second SRTM DEM. We find a slight mass loss of −0.09 ± 0.03 m w.e. a−1 (12 366 km2) for 1973–2000, which is less negative than the global average rate for 1971–2009 (−0.31 ± 0.19 m w.e. a−1). Within the Karakoram, the glacier change patterns are spatially and temporally heterogeneous. In particular, a nearly stable state in the central Karakoram (−0.04 ± 0.05 m w.e. a−1 during the period 1974–2000) implies that the Karakoram anomaly dates back to the 1970s. Combined with the previous studies, we conclude that the Karakoram glaciers as a whole were in a nearly balanced state during the 1970s to the 2010s.
Facies analysis and depositional model of the Serravallian-age Neurath Sand, Lower Rhine Basin (W Germany)
Authors: Prinz L. , Schäfer A. , McCann T. , Utescher T. , Lokay P. , Asmus S.
Published: January 2017

The up to 60 m thick Neurath Sand (Serravallian, late middle Miocene) is one of several marine sands in the Lower Rhine Basin which were deposited as a result of North Sea transgressive activity in Cenozoic times. The shallow-marine Neurath Sand is well exposed in the Garzweiler open-cast mine, which is located in the centre of the Lower Rhine Basin. Detailed examination of three sediment profiles extending from the underlying Frimmersdorf Seam via the Neurath Sand and through to the overlying Garzweiler Seam, integrating both sedimentological and palaeontological data, has enabled the depositional setting of the area to be reconstructed.

Six subenvironments are recognised in the Neurath Sand, commencing with the upper shoreface (1) sediments characterised by glauconite-rich sands and an extensive biota (Ophiomorphaichnosp.). These are associated with the silt-rich sands of a transitional subenvironment (2), containingSkolithos linearis, Planolitesichnosp. andTeichichnusichnosp. These silt-rich sands grade up to the upper shoreface subenvironment (1), which is indicative of an initial regressive trend. The overlying intertidal deposits can be subdivided into a lower breaker zone (3), characterised by ridge-and-runnel systems, and the swash zone (4) where the surge and backwash of waves resulted in the deposition of high-energy laminites. The intertidal deposits were capped by aeolian backshore sediments (5). Extensive root traces present in this latter subenvironment reflect the development of the overlying peatland (i.e. Garzweiler Seam). Within the Garzweiler Seam, restricted sand lenses indicate a lagoonal or estuarine depositional environment (6). Regional correlation with adjacent wells establishes that shallow-marine conditions were widespread across the Lower Rhine Basin in middle Serravallian times. The shoreline profile, characterised by both tidal and wave activity and influenced by fluvial input from the adjacent Rhenish Massif, is indicative of the complexity of the coastal depositional setting within the Lower Rhine Basin.
Energy density of the diets of Japanese adults in relation to food and nutrient intake and general and abdominal obesity: a cross-sectional analysis from the 2012 National Health and Nutrition Survey, Japan
Authors: Murakami Kentaro , Livingstone M. Barbara E. , Okubo Hitomi , Sasaki Satoshi
Published: January 2017

The associations of dietary energy density with dietary intake and obesity have been largely unexplored in non-Western populations. The present cross-sectional study examined the associations using data from the 2012 National Health and Nutrition Survey, Japan. Dietary intake was assessed using a 1-d semi-weighed dietary record in 15 618 Japanese adults aged ≥20 years. Mean dietary energy density (calculated on the basis of foods only) was 5·98 (sd 1·20) kJ/g in men and 5·72 (sd 1·16) kJ/g in women. Dietary energy density was positively associated with intakes of bread, noodles (only men), meat, fats and oils, and sugar and confectionery but inversely with intakes of white rice (only men), potatoes, pulses, vegetables, fruits, and fish and shellfish. For nutrient intake, dietary energy density was positively associated with total fat and SFA but inversely associated with all other nutrients examined such as protein, carbohydrate, alcohol (only women), dietary fibre, and several vitamins and minerals, including Na. After adjustment for potential confounding factors, dietary energy density was positively associated with abdominal obesity (waist circumference ≥80 cm) in women (adjusted prevalence ratio between the extreme tertiles 1·07; 95 % CI 1·02, 1·12; Pfor trend=0·003). Dietary energy density was also positively but non-significantly associated with general obesity (BMI≥25 kg/m2) in women (Pfor trend=0·08). There were no such associations in men. In conclusion, lower energy density of the diets of Japanese adults was associated with favourable food and nutrient intake patterns, except for higher Na, and, in only women, a lower prevalence of abdominal obesity.
Geography Matters: The Conditional Effect of Electoral Systems on Social Spending
Authors: Jurado Ignacio , León Sandra
Published: January 2017

There is a large body of research showing that the provision of social policies is higher under proportional electoral systems than under majoritarian systems. This article helps advance this literature by showing that the geographic distribution of social recipients plays an essential role in moderating the impact of electoral institutions on social provision. Using data from twenty-two OECD countries, the results show that majoritarian systems increase the provision of social spending when recipients are concentrated in certain regions. When levels of concentration are high, social spending in majoritarian countries can surpass levels of provision in proportional representation systems.
Induction of resistance of corn plants to Spodoptera frugiperda (J. E. Smith, 1797) (Lepidoptera: Noctuidae) by application of silicon and gibberellic acid
Authors: Alvarenga R. , Moraes J. C. , Auad A. M. , Coelho M. , Nascimento A. M.
Published: January 2017

The aim of this study was to evaluate the effects of silicon application and administration of the phytohormone gibberellic acid on resistance of the corn plants to the fall armyworm (FAW), Spodoptera frugiperda, and their vegetative characteristics. We evaluated larval and pupal duration, survival and biomass, and adult longevity, malformation and fecundity of S. frugiperda after feeding on plant matter treated with silicon and/or gibberellic acid. The feeding preference of FAW first-instar larvae, the total leaf area consumed by the insects, and the vegetative parameters of corn plants were also evaluated. No significant differences were observed in the measured parameters of larval and pupal stages of S. frugiperda in response to silicon or gibberellic acid. In adult stage insects, the number of eggs per female was significantly reduced in insects derived from larvae fed plants treated with silicon or gibberellic acid. In a non-preference test, 48 h after release, caterpillars preferred control untreated plants and consumed less matter from plants that had received hormonal treatment (gibberellic acid). Gibberellic acid also altered the vegetative characteristics of plants, by increasing their height, shoot fresh and dry mass, and silicon content. We conclude that gibberellic acid can alter the vegetative characteristics and silicon uptake of corn plants, leading to a reduction in their consumption by S. frugiperda larvae and a decrease in female insect oviposition.
A new vauxiid sponge from the Kaili Biota (Cambrian Stage 5), Guizhou, South China
Authors: YANG XINGLIAN , ZHAO YUANLONG , BABCOCK LOREN E. , PENG JIN
Published: January 2017

The skeleton of a new vauxiid sponge (Order Verongida),Angulosuspongia sinensisgen. et sp. nov., described on the basis of material from calcareous mudstones of the Kaili Formation (Cambrian Stage 5), Jianhe area, Guizhou, South China, is composed of two layers of fused spicules outlining hexagonal or polygonal openings. These vauxiid remains are the first reported from outside Laurentia, and represent only the second genus attributed to the family. Its age is close to but still slightly older than the Burgess Shale Biota, and it appears to be a primitive relative of other members of the Vauxiidae. The morphological differences between Chinese and Laurentian vauxiid sponges may be a result of vicariance. These specimens not only extend the geographic distribution of vauxiids, but also help to fill a chronostratigraphical gap between North Greenland and North American material and provide additional evidence for understanding the evolutionary history of the Demospongiae.
Two live sightings of Sowerby's beaked whale (Mesoplodon bidens) from the western Mediterranean (Tyrrhenian Sea)
Authors: Bittau Luca , Leone Mattia , Gannier Adrien , Gannier Alexandre , Manconi Renata
Published: January 2017

Sowerby's beaked whale (Mesoplodon bidens) was previously known in the Mediterranean Sea from a single live stranding of two individuals in the French Riviera. We report here on two live sightings in the western Mediterranean, central-western Tyrrhenian Sea off eastern Corsica (Montecristo Trough) and off eastern Sardinia (Caprera Canyon) in 2010 and 2012, respectively. In both cases single individuals, possibly the same individual, occurred within groups of Cuvier's beaked whales (Ziphius cavirostris) suggesting inter-specific interactions. Based on our close observations of mixed-species groups of Sowerby's and Cuvier's beaked whales, we hypothesize that some previous long-distance sightings of beaked whales in the Mediterranean may not be reliably attributed toZ. cavirostris. The present sightings and previous live stranding indicate that the western Mediterranean Sea is the easternmost marginal area ofM. bidenswithin the North Atlantic geographic range. Notes on behaviour are also provided.
Disturbance alters ecosystem engineering by a canopy-forming alga
Authors: Pocklington Jacqueline B. , Jenkins Stuart R. , Bellgrove Alecia , Keough Michael J. , O'Hara Tim D. , Masterson-Algar Patricia E. , Hawkins Stephen J.
Published: January 2017

Canopy-forming fucoid algae have an important role as ecosystem engineers on rocky intertidal shores, where they increase the abundance of species otherwise limited by exposure during low tide. The facilitative relationship betweenAscophyllum nodosumand associated organisms was explored using a frond breakage experiment (100%, 50%, 25%, 0% intact-frond treatments) in southern England, to assess the consequences of disturbance. Understorey substratum temperature was on average 3°C higher in 0% and 25% intact-frond treatments than in plots with 50% and 100% intact fronds. Light (as PAR during low tide) doubled in 0% intact-frond treatments in comparison to other treatments (which had similar light levels). Mobile invertebrate species richness declined by on average 1 species per m2in the treatments with only 25% and 0% intact fronds, and the abundance ofLittorina obtusatadeclined by 2.4–4.2 individuals per m2in the treatments with 25 and 0% intact fronds. Sessile taxa, includingOsmundea pinnatifidaand encrusting coralline algae, declined by half on average in the 0% intact-frond treatment. These results suggest that the ability ofAscophyllumto mediate environmental conditions to the understorey is the mechanism responsible for species distributed in the understorey (autogenic ecosystem engineering). The results of this study imply that a pulse disturbance resulting in a 50% breakage ofAscophyllumfronds significantly increases temperature and decreases the abundance of mobile invertebrates usually associated withAscophyllum. Sessile taxa associated withAscophyllumcan, however, withstand disturbances down to 25% intactAscophyllumfronds.
Exploring the main threats to the threatened African spurred tortoiseCentrochelys sulcatain the West African Sahel
Authors: Petrozzi Fabio , Eniang Edem A. , Akani Godfrey C. , Amadi Nioking , Hema Emmanuel M. , Diagne Tomas , Segniagbeto Gabriel Hoinsoudé , Chirio Laurent , Amori Giovanni , Luiselli Luca
Published: January 2017

The African spurred tortoiseCentrochelys sulcatais the second largest terrestrial turtle, with a scattered distribution across the West African Sahel. This species is threatened and declining consistently throughout its range, but little is known about the causes of its decline. It has been hypothesized that the decline is attributable to (1) competition with domestic cattle, (2) wildfire, and (3) the international pet trade. We conducted a series of analyses to investigate these three causes. Hypotheses 1 and 2 were analysed using a spatially explicit approach, using a database of the Food and Agriculture Organization of the United Nations and logistic regression modelling; hypothesis 3 was tested by analysing the CITES trade database for 1990–2010. We found a significant negative correlation between intensity of grazing (expressed as density of cattle, km−2) and the presence of spurred tortoises, and this negative effect increased when coupled with high fire intensity, whereas wildfires alone did not have a significant influence on the species’ distribution at the global scale. There was a decrease in the annual export of wild individuals for the pet trade after the introduction of export quotas by country and by year, but trade data must be considered with caution.
Obstetrical, pregnancy and socio-economic predictors for new-onset severe postpartum psychiatric disorders in primiparous women
Authors: Meltzer-Brody S. , Maegbaek M. L. , Medland S. E. , Miller W. C. , Sullivan P. , Munk-Olsen T.
Published: January 2017

Background

Childbirth is a potent trigger for the onset of psychiatric illness in women including postpartum depression (PPD) and postpartum psychosis (PP). Medical complications occurring during pregnancy and/or childbirth have been linked to postpartum psychiatric illness and sociodemographic factors. We evaluated if pregnancy and obstetrical predictors have similar effects on different types of postpartum psychiatric disorders.

Method

A population-based cohort study using Danish registers was conducted in 392 458 primiparous women with a singleton delivery between 1995 and 2012 and no previous psychiatric history. The main outcome was first-onset postpartum psychiatric episodes. Incidence rate ratios (IRRs) were calculated for any psychiatric contact in four quarters for the first year postpartum.

Results

PPD and postpartum acute stress reactions were associated with pregnancy and obstetrical complications. For PPD, hyperemesis gravidarum [IRR 2.69, 95% confidence interval (CI) 1.93–3.73], gestational hypertension (IRR 1.84, 95% CI 1.33–2.55), pre-eclampsia (IRR 1.45, 95% CI 1.14–1.84) and Cesarean section (C-section) (IRR 1.32, 95% CI 1.13–1.53) were associated with increased risk. For postpartum acute stress, hyperemesis gravidarum (IRR 1.93, 95% CI 1.38–2.71), preterm birth (IRR 1.51, 95% CI 1.30–1.75), gestational diabetes (IRR 1.42, 95% CI 1.03–1.97) and C-section (IRR 1.36, 95% CI 1.20–1.55) were associated with increased risk. In contrast, risk of PP was not associated with pregnancy or obstetrical complications.

Conclusions

Pregnancy and obstetrical complications can increase the risk for PPD and acute stress reactions but not PP. Identification of postpartum women requiring secondary care is needed to develop targeted approaches for screening and treatment. Future work should focus on understanding the contributions of psychological stressors and underlying biology on the development of postpartum psychiatric illness.
Coeliac disease and invasive pneumococcal disease: a population-based cohort study
Authors: RÖCKERT TJERNBERG A. , BONNEDAHL J. , INGHAMMAR M. , EGESTEN A. , KAHLMETER G. , NAUCLÉR P. , HENRIQUES-NORMARK B. , LUDVIGSSON J. F.
Published: January 2017

Severe infections are recognized complications of coeliac disease (CD). In the present study we aimed to examine whether individuals with CD are at increased risk of invasive pneumococcal disease (IPD). To do so, we performed a population-based cohort study including 29 012 individuals with biopsy-proven CD identified through biopsy reports from all pathology departments in Sweden. Each individual with CD was matched with up to five controls (n = 144 257). IPD events were identified through regional and national microbiological databases, including the National Surveillance System for Infectious Diseases. We used Cox regression analyses to estimate hazard ratios (HRs) for diagnosed IPD. A total of 207 individuals had a record of IPD whereas 45/29 012 had CD (0·15%) and 162/144 257 were controls (0·11%). This corresponded to a 46% increased risk for IPD [HR 1·46, 95% confidence interval (CI) 1·05–2·03]. The risk estimate was similar after adjustment for socioeconomic status, educational level and comorbidities, but then failed to attain statistical significance (adjusted HR 1·40, 95% CI 0·99–1·97). Nonetheless, our study shows a trend towards an increased risk for IPD in CD patients. The findings support results seen in earlier research and taking that into consideration individuals with CD may be considered for pneumococcal vaccination.
Nutrition, infection and stunting: the roles of deficiencies of individual nutrients and foods, and of inflammation, as determinants of reduced linear growth of children
Authors: Millward D. Joe
Published: January 2017

The regulation of linear growth by nutritional and inflammatory influences is examined in terms of growth-plate endochondral ossification, in order to better understand stunted growth in children. Linear growth is controlled by complex genetic, physiological, and nutrient-sensitive endocrine/paracrine/autocrine mediated molecular signalling mechanisms, possibly including sleep adequacy through its influence on growth hormone secretion. Inflammation, which accompanies most infections and environmental enteric dysfunction, inhibits endochondral ossification through the action of mediators including proinflammatory cytokines, the activin A-follistatin system, glucocorticoids and fibroblast growth factor 21 (FGF21). In animal models linear growth is particularly sensitive to dietary protein as well as Zn intake, which act through insulin, insulin-like growth factor-1 (IGF-1) and its binding proteins, triiodothyronine, amino acids and Zn2+to stimulate growth-plate protein and proteoglycan synthesis and cell cycle progression, actions which are blocked by corticosteroids and inflammatory cytokines. Observational human studies indicate stunting to be associated with nutritionally poor, mainly plant-based diets. Intervention studies provide some support for deficiencies of energy, protein, Zn and iodine and for multiple micronutrient deficiencies, at least during pregnancy. Of the animal-source foods, only milk has been specifically and repeatedly shown to exert an important influence on linear growth in both undernourished and well-nourished children. However, inflammation, caused by infections, environmental enteric dysfunction, which may be widespread in the absence of clean water, adequate sanitation and hygiene (WASH), and endogenous inflammation associated with excess adiposity, in each case contributes to stunting, and may explain why nutritional interventions are often unsuccessful. Current interventions to reduce stunting are targeting WASH as well as nutrition.
Feeding difficulties in neonates following cardiac surgery: determinants of prolonged feeding-tube use
Authors: McKean Elissa B. , Kasparian Nadine A. , Batra Shweta , Sholler Gary F. , Winlaw David S. , Dalby-Payne Jacqueline
Published: January 2017

Aim

The aims of this study were to examine the prevalence and potential correlates of feeding difficulties in infants who underwent cardiac surgery in the neonatal period and to investigate resource utilisation by infants with feeding difficulties.

Methods

All neonates who underwent their first cardiac surgery at the Heart Centre for Children, The Children’s Hospital at Westmead, between January and December, 2009 were included. Demographic, preoperative, intraoperative, and postoperative data were collected via electronic medical records. For the purpose of this study, feeding difficulty was defined as the requirement for ongoing tube feeding at the time of discharge home or transfer to another hospital.

Results

Out of a total of 79 neonates, 24 (30%) were discharged home or transferred to another hospital with a feeding tube. Feeding difficulties were associated with the presence of a genetic syndrome (p<0.0001), assisted feeding preoperatively (odds ratio (OR)=4.4, p=0.03), and having a palliative procedure before biventricular repair (OR=5.1, p=0.02). Infants with feeding difficulties had significantly more reviews by speech pathologists (M=5.9, SD=7.9), dieticians (M=5.9, SD=5.4), and cardiac clinical nurse consultants (M=1.2, SD=1.4) compared with those without feeding difficulties.

Conclusions

This study identified factors that can be used in the early recognition of infant feeding difficulties, to help guide the direction of limited health resources, as well as being focal points for future research and clinical practice improvement.
BANKING, LIQUIDITY EFFECTS, AND MONETARY POLICY
Authors: Chang Te-Tsun , Li Yiting
Published: January 2017

We study liquidity effects and monetary policy in a model with fully flexible prices and explicit roles for money and financial intermediation. Banks hold some fractions of deposits and money injections as liquidity buffers. The higher the fraction kept as reserves, the less liquid the money is. Unexpected money injections raise output and lower nominal interest rates if and only if the newly injected money is more liquid than the initial money stocks. If banks hold no liquidity buffers, liquidity effects are eliminated. In an extended model with temporary shocks, we show that failure to withdraw state-contingent money injections does not make the stabilization policy neutral, though the economy may undergo higher short-run fluctuations than otherwise. Under this circumstance, the success of stabilization policy relies on unexpected money injections being more liquid than the initial money stock.
Hypertension and diabetes prevalence among adults with moderately increased BMI (23·0–24·9 kg/m2): findings from a nationwide survey in Bangladesh
Authors: Rahman Muntasirur , Williams Gail , Mamun Abdullah Al
Published: January 2017

Objective

BMI is a proxy for fat accumulation in the body. Increased diabetes and CVD risks have been observed for Asian populations at lower BMI than the WHO-recommended BMI cut-off points for overweight (≥25·0 kg/m2) and obesity (≥30·0 kg/m2). The current study aimed to quantify the increased hypertension (HTN) and type 2 diabetes mellitus (T2DM) prevalence in Bangladeshi adults with moderately increased BMI (23·0–24·9 kg/m2).

Design

Data from the most recent Bangladesh Demographic and Health Survey (2011) were analysed. Modified Poisson regression models with robust error variance were used to calculate prevalence ratios (PR) for HTN or T2DM by BMI category, considering BMI=18·5–22·9 kg/m2 as the reference. All analyses incorporated the complex sampling design of the survey.

Setting

BMI, blood pressure, blood sugar and related information were collected from a nationally representative sample.

Subjects

Adults (n 7433) aged≥35 years.

Results

About 12 % of Bangladeshi adults, both male and female, were within the BMI range 23·0–24·9 kg/m2 or moderately overweight. Compared with the reference BMI group (18·5–22·9 kg/m2), they had an increased PR for HTN (1·55–1·77) and T2DM (1·54–1·93). These increased PR are similar to those for the WHO-defined overweight group (BMI=25·0–29·9 kg/m2).

Conclusions

Our findings support the recommendation that calls for setting the optimum BMI for Asian populations to 18·5–23·0 kg/m2 for health promotion and for public health interventions like leisure-time physical activity. WHO cut-off points for overweight (≥25 kg/m2) should be used to facilitate international comparisons.
A Dual Laser Scanning Confocal and Transmission Electron Microscopy Analysis of the Intracellular Localization, Aggregation and Particle Formation of African Horse Sickness Virus Major Core Protein VP7
Authors: Wall Gayle V. , Rutkowska Daria A. , Mizrachi Eshchar , Huismans Henk , van Staden Vida
Published: January 2017

The bulk of the major core protein VP7 in African horse sickness virus (AHSV) self-assembles into flat, hexagonal crystalline particles in a process appearing unrelated to viral replication. Why this unique characteristic of AHSV VP7 is genetically conserved, and whether VP7 aggregation and particle formation have an effect on cellular biology or the viral life cycle, is unknown. Here we investigated how different small peptide and enhanced green fluorescent protein (eGFP) insertions into the VP7 top domain affected VP7 localization, aggregation, and particle formation. This was done using a dual laser scanning confocal and transmission electron microscopy approach in conjunction with analyses of the solubility, aggregation, and fluorescence profiles of the proteins. VP7 top domain modifications did not prevent trimerization, or intracellular trafficking, to one or two discrete sites in the cell. However, modifications that resulted in a misfolded and insoluble VP7-eGFP component blocked trafficking, and precluded protein accumulation at a single cellular site, perhaps by interfering with normal trimer–trimer interactions. Furthermore, the modifications disrupted the stable layering of the trimers into characteristic AHSV VP7 crystalline particles. It was concluded that VP7 trafficking is driven by a balance between VP7 solubility, trimer forming ability, and trimer–trimer interactions.
Physicians' perceptions of suffering in people with dementia at the end of life
Authors: van der Steen Jenny T. , Deliens Luc , Koopmans Raymond T.C.M. , Onwuteaka-Philipsen Bregje D.
Published: January 2017

Objective:

Our aim was to describe physicians' perceptions of the suffering of their patients who are dying with dementia, many of whom are incompetent with regard to decision making and have difficulty with communicating about the source of their distress and with identifying related factors.

Method:

We analyzed data from the nationally representative observational Dutch End-of-Life in Dementia (DEOLD) cohort study (2007–2011), which involved 34 long-term care facilities. A total of 103 physicians completed questionnaires about 330 patients with dementia who had died in a participating facility. Suffering during the last six hours of life was defined as “a patient being disturbed by or aware of symptoms,” “suffering until the end or death was a struggle”—all related to objective indicators of lack of comfort. We employed generalized estimating equation models to assess associations of suffering with the characteristics of physicians and patients, the patient's death, and the decision-making process.

Results:

In 13.8% of cases, the physician felt that the patient had suffered. An unexpected death and death with pneumonia were strongly (an odds ratios close to 6) associated with suffering, and suffering was also independently associated with the physician's perception of worse quality of end-of-life care, death with cardiovascular disease, a less experienced physician, no palliative sedation, and a younger patient.

Significance of Results:

Most patients with dementia did not suffer during their final hours of life, according to their physicians. There are a number of factors associated with suffering, among them death with pneumonia and unexpected death. We may not be able to have much influence on death from pneumonia, but quality of care and an unexpected death are reasonable targets for intervention. Earlier identification of the beginning of the dying process would allow time to better prepare for approaching death, which would provide a source of comfort.
A quantitative real-time approach for discriminating apoptosis and necrosis
Authors: Lekshmi Asha , Varadarajan Shankara Narayanan , Lupitha Santhik Subhasingh , Indira Deepa , Mathew Krupa Ann , Chandrasekharan Nair Aneesh , Nair Mydhily , Prasad Tilak , Sekar Hari , Gopalakrishnan Anurup Kochucherukkan , Murali Abitha , Santhoshkumar Thankayyan Retnabai
Published: January 2017

Apoptosis and necrosis are the two major forms of cell death mechanisms. Both forms of cell death are involved in several physiological and pathological conditions and also in the elimination of cancer cells following successful chemotherapy. Large number of cellular and biochemical assays have evolved to determine apoptosis or necrosis for qualitative and quantitative purposes. A closer analysis of the assays and their performance reveal the difficulty in using any of these methods as a confirmatory approach, owing to the secondary induction of necrosis in apoptotic cells. This highlights the essential requirement of an approach with a real-time analysis capability for discriminating the two forms of cell death. This paper describes a sensitive live cell-based method for distinguishing apoptosis and necrosis at single-cell level. The method uses cancer cells stably expressing genetically encoded FRET-based active caspase detection probe and DsRed fluorescent protein targeted to mitochondria. Caspase activation is visualized by loss of FRET upon cleavage of the FRET probe, while retention of mitochondrial fluorescence and loss of FRET probe before its cleavage confirms necrosis. The absence of cleavage as well as the retention of mitochondrial fluorescence indicates live cells. The method described here forms an extremely sensitive tool to visualize and quantify apoptosis and necrosis, which is adaptable for diverse microscopic, flow cytometric techniques and high-throughput imaging platforms with potential application in diverse areas of cell biology and oncology drug screening.
Cancer stem-like cells can be induced through dedifferentiation under hypoxic conditions in glioma, hepatoma and lung cancer
Authors: Wang Pan , Wan Wen-wu , Xiong Shuang-Long , Feng Hua , Wu Nan
Published: January 2017

Traditional studies have shown that transcription factors, including SOX-2, OCT-4, KLF-4, Nanog and Lin-28A, contribute to the dedifferentiation and reprogramming process in normal tissues. Hypoxia is a physiological phenomenon that exists in tumors and promotes the expression of SOX-2, OCT-4, KLF-4, Nanog and Lin-28A. Therefore, an interesting question is whether hypoxia as a stimulating factor promotes the process of dedifferentiation and induces the formation of cancer stem-like cells. Studies have shown that OCT-4 and Nanog overexpression induced the formation of cancer stem cell-like cells through dedifferentiation and enhanced malignancy in lung adenocarcinoma, and reprogramming SOX-2 in pancreatic cancer cells also promoted the dedifferentiation process. Therefore, we investigated this phenomenon in glioma, lung cancer and hepatoma cells and found that the transcription factors mentioned above were highly expressed under hypoxic conditions and induced the formation of spheres, which exhibited asymmetric division and cell cycle arrest. The dedifferentiation process induced by hypoxia highlights a new pattern of cancer development and recurrence, demonstrating that all kinds of cancer cells and the hypoxic microenvironment should be taken into consideration when developing tumor therapies.
Mechanotransductive cascade of Myo-II-dependent mesoderm and endoderm invaginations in embryo gastrulation
Authors: Mitrossilis Démosthène , Röper Jens-Christian , Le Roy Damien , Driquez Benjamin , Michel Aude , Ménager Christine , Shaw Gorky , Le Denmat Simon , Ranno Laurent , Dumas-Bouchiat Frédéric , Dempsey Nora M. , Farge Emmanuel
Published: January 2017

Animal development consists of a cascade of tissue differentiation and shape change. Associated mechanical signals regulate tissue differentiation. Here we demonstrate that endogenous mechanical cues also trigger biochemical pathways, generating the active morphogenetic movements shaping animal development through a mechanotransductive cascade of Myo-II medio-apical stabilization. To mimic physiological tissue deformation with a cell scale resolution, liposomes containing magnetic nanoparticles are injected into embryonic epithelia and submitted to time-variable forces generated by a linear array of micrometric soft magnets. Periodic magnetically induced deformations quantitatively phenocopy the soft mechanical endogenous snail-dependent apex pulsations, rescue the medio-apical accumulation of Rok, Myo-II and subsequent mesoderm invagination lacking in sna mutants, in a Fog-dependent mechanotransductive process. Mesoderm invagination then activates Myo-II apical accumulation, in a similar Fog-dependent mechanotransductive process, which in turn initiates endoderm invagination. This reveals the existence of a highly dynamic self-inductive cascade of mesoderm and endoderm invaginations, regulated by mechano-induced medio-apical stabilization of Myo-II.
Transformable topological mechanical metamaterials
Authors: Rocklin D. Zeb , Zhou Shangnan , Sun Kai , Mao Xiaoming
Published: January 2017

Mechanical metamaterials are engineered materials whose structures give them novel mechanical properties, including negative Poisson’s ratios, negative compressibilities and phononic bandgaps. Of particular interest are systems near the point of mechanical instability, which recently have been shown to distribute force and motion in robust ways determined by a nontrivial topological state. Here we discuss the classification of and propose a design principle for mechanical metamaterials that can be easily and reversibly transformed between states with dramatically different mechanical and acoustic properties via a soft strain. Remarkably, despite the low energetic cost of this transition, quantities such as the edge stiffness and speed of sound can change by orders of magnitude. We show that the existence and form of a soft deformation directly determines floppy edge modes and phonon dispersion. Finally, we generalize the soft strain to generate domain structures that allow further tuning of the material.