bluuebunny/crossref_metadata_2025 huggingface dataset:
Ferroelectricity in untwisted heterobilayers of transition metal dichalcogenides
Authors: Rogée Lukas , Wang Lvjin , Zhang Yi , Cai Songhua , Wang Peng , Chhowalla Manish , Ji Wei , Lau Shu Ping
Published: May 2022

Two-dimensional materials with out-of-plane (OOP) ferroelectric and piezoelectric properties are highly desirable for the realization of ultrathin ferro- and piezoelectronic devices. We demonstrate unexpected OOP ferroelectricity and piezoelectricity in untwisted, commensurate, and epitaxial MoS
2
/WS
2
heterobilayers synthesized by scalable one-step chemical vapor deposition. We show
d
33
piezoelectric constants of 1.95 to 2.09 picometers per volt that are larger than the natural OOP piezoelectric constant of monolayer In
2
Se
3
by a factor of ~6. We demonstrate the modulation of tunneling current by about three orders of magnitude in ferroelectric tunnel junction devices by changing the polarization state of MoS
2
/WS
2
heterobilayers. Our results are consistent with density functional theory, which shows that both symmetry breaking and interlayer sliding give rise to the unexpected properties without the need for invoking twist angles or moiré domains.
Models predict planned phosphorus load reduction will make Lake Erie more toxic
Authors: Hellweger Ferdi L. , Martin Robbie M. , Eigemann Falk , Smith Derek J. , Dick Gregory J. , Wilhelm Steven W.
Published: May 2022

Harmful cyanobacteria are a global environmental problem, yet we lack actionable understanding of toxigenic versus nontoxigenic strain ecology and toxin production. We performed a large-scale meta-analysis including 103 papers and used it to develop a mechanistic, agent-based model of
Microcystis
growth and microcystin production. Simulations for Lake Erie suggest that the observed toxigenic-to-nontoxigenic strain succession during the 2014 Toledo drinking water crisis was controlled by different cellular oxidative stress mitigation strategies (protection by microcystin versus degradation by enzymes) and the different susceptibility of those mechanisms to nitrogen limitation. This model, as well as a simpler empirical one, predicts that the planned phosphorus load reduction will lower biomass but make nitrogen and light more available, which will increase toxin production, favor toxigenic cells, and increase toxin concentrations.
Actions for reducing US emissions at least 50% by 2030
Authors: Bistline John , Abhyankar Nikit , Blanford Geoffrey , Clarke Leon , Fakhry Rachel , McJeon Haewon , Reilly John , Roney Christopher , Wilson Tom , Yuan Mei , Zhao Alicia
Published: May 2022

Policies must help decarbonize power and transport sectors
The effects of oral microbiota on health
Authors: Tuganbaev Timur , Yoshida Koji , Honda Kenya
Published: May 2022

Oral microbiota form complex biofilms that can affect local and systemic health
Hydrotrioxide (ROOOH) formation in the atmosphere
Authors: Berndt Torsten , Chen Jing , Kjærgaard Eva R. , Møller Kristian H. , Tilgner Andreas , Hoffmann Erik H. , Herrmann Hartmut , Crounse John D. , Wennberg Paul O. , Kjaergaard Henrik G.
Published: May 2022

Organic hydrotrioxides (ROOOH) are known to be strong oxidants used in organic synthesis. Previously, it has been speculated that they are formed in the atmosphere through the gas-phase reaction of organic peroxy radicals (RO
2
) with hydroxyl radicals (OH). Here, we report direct observation of ROOOH formation from several atmospherically relevant RO
2
radicals. Kinetic analysis confirmed rapid RO
2
+ OH reactions forming ROOOH, with rate coefficients close to the collision limit. For the OH-initiated degradation of isoprene, global modeling predicts molar hydrotrioxide formation yields of up to 1%, which represents an annual ROOOH formation of about 10 million metric tons. The atmospheric lifetime of ROOOH is estimated to be minutes to hours. Hydrotrioxides represent a previously omitted substance class in the atmosphere, the impact of which needs to be examined.
Delta-scale solutions for human-scale needs
Authors: Passalacqua Paola , Moodie Andrew J.
Published: May 2022

Global studies inform river management needed for landscape sustainability
Antibiotics made to order
Authors: Seipke Ryan F.
Published: May 2022

New lipopeptide antibiotics provide hope in the fight against multidrug-resistant bacteria
Mental health care 2.0
Authors: Insel Thomas
Published: May 2022

While the COVID-19 pandemic has been a burden for our mental health, it also led to a surge in mental health care innovation. Appointments by telephone or video, as well as web- and app-based tools, have become part of a digital mental health revolution. Last year, US venture capitalists invested $5.1 billion in this area, a fivefold increase from 2019. But is this surge in activity actually leading to improvements for those with the greatest needs?
We know what the problem is
Authors: Thorp H. Holden
Published: May 2022

America is reeling from yet another devastating spate of mass shootings. Last month, in the span of 10 days, shooters targeted a Taiwanese church in California, a grocery store in a Black neighborhood in New York, and an elementary school in Texas. Although opponents of sensible gun control—the kind that prevails throughout most of the civilized world—continue to put the spotlight on the shooters’ motivations or unstable mental states, these are cynical diversions from the one obvious truth: The common thread in all of the country’s revolting mass shootings is the absurdly easy access to guns. The science is clear: Restrictions work, and it’s likely that even more limitations would save thousands of lives. So why not take the laws much further, as other countries have done? The alternative is painfully obvious—living with more and more senseless carnage, courtesy of the National Rifle Association and their well-funded political lackeys.
Whole-Genome Sequence of Streptococcus iniae Strain AH1, Isolated from Hybrid Tilapia (Oreochromis niloticus × Oreochromis aureus)
Authors: Al-Harbi Ahmed H.
Published: May 2022

Here, we describe the whole-genome sequence of
Streptococcus iniae
strain AH1, which was isolated from moribund farmed hybrid tilapia (
Oreochromis niloticus
×
Oreochromis aureus
) in Saudi Arabia. The genome is composed of a single linear chromosome of 2,068,661 bp, with a G+C content of 36.8%.
Complete Genome Sequences of Mannanase-Producing
Bacillus
and
Niallia
Strains Isolated from the Intestine of the Black Tiger Shrimp (Penaeus monodon)
Authors: Sathitkowitchai Witida , Wongsurawat Thidathip , Jenjaroenpun Piroon , Angthong Pacharaporn , Nuanpirom Jiratchaya , Sathapondecha Ponsit , Rungrassamee Wanilada
Published: May 2022

Here, we report the complete genome sequences of mannanase-producing bacteria, namely,
Niallia
sp. strain Man26 and
Bacillus subtilis
strain Man122, isolated from the intestine of
Penaeus monodon
, the black tiger shrimp. Mannanases are used in various industries, such as food, animal feed, and biorefinery, to hydrolyze mannan to oligomers and mannose.
Genomic characterization of
Lelliottia amnigena
PTJIIT1005, a nitrate tolerant strain isolated from water sample of Yamuna River, Delhi, India
Authors: Thakur Preeti , Gauba Pammi
Published: May 2022

Here, we report the genome sequence of PTJIIT1005, isolated from a polluted site on the Yamuna River, Delhi. The genome is complete and consists of ~4.5 Mbp with a GC content of 52.62%, 4,259 protein-coding genes, 76 tRNAs, and 4 rRNAs. Strain PTJIIT1005 shows 98.89% average nucleotide identity (ANI) with
Lelliottia amnigena
.
Multiple Genomes of Foot-and-Mouth Disease Virus Serotype Asia-1 Obtained from Subclinically Infected Asian Buffalo (Bubalus bubalis) in Pakistan
Authors: Stenfeldt Carolina , Bertram Miranda , Holinka-Patterson Lauren , Fish Ian , Farooq Umer , Ahmed Zaheer , Hartwig Ethan J. , Smoliga George R. , Naeem Khalid , Meek Haillie C. , Pauszek Steven J. , Rodriguez Luis , Arzt Jonathan
Published: May 2022

We report the near-full-genome sequences of 49 isolates of serotype Asia-1 foot-and-mouth disease virus obtained from subclinically infected Asian buffalo in Islamabad Capital Region, Pakistan, in 2011 to 2012. Sequences from subclinically infected animals are exceedingly rare and complement the more commonly available sequences acquired from clinical cases.
A Novel Algicidal Bacterium and Its Effects against the Toxic Dinoflagellate
Karenia mikimotoi
(Dinophyceae)
Authors: Shi Xinguo , Zou Yazhen , Zheng Wenhuang , Liu Lemian , Xie Youping , Ma Ruijuan , Chen Jianfeng
Published: May 2022

K. mikimotoi
is a noxious algal bloom-forming species that cause damaging of the aquaculture industry and great financial losses. Bacterium with algicidal activity is an ideal agency to inhibit the growth of harmful algae.
Rapid Detection of MCR-Mediated Colistin Resistance in Escherichia coli
Authors: Zhang Haijie , Yu Feiyu , Lu Xiaoyu , Li Yan , Peng Daxin , Wang Zhiqiang , Liu Yuan
Published: May 2022

The emergence and prevalence of
mcr-1
and its variants in humans, animals, and the environment pose a global public health threat. There is a pressing urgency to develop rapid and accurate methods to identify MCR-positive colistin-resistant bacteria in the clinical samples, providing a basis for subsequent effective antibiotic treatment.
Evaluation of Four Point of Care (POC) Antigen Assays for the Detection of the SARS-CoV-2 Variant Omicron
Authors: Hardick Justin , Gallagher Nicholas , Sachithanandham Jaiprasath , Fall Amary , Siddiqui Zishan , Pekosz Andrew , Manabe Yukari C. , Mostafa Heba H.
Published: May 2022

In the manuscript, we report an evaluation of the capability of 4 point of care (POC) antigen assays, the BD Veritor, Abbott BinaxNow, Orasure InteliSwab and Quidel QuickVue to detect the Omicron variant of SARS-CoV-2, and we compared their analytical sensitivity for Omicron versus Delta. In this analysis we found that all four assays detected Omicron and Delta at 104and 105TCID50/mL, respectively.
Bacterial Infection Induces Ultrastructural and Transcriptional Changes in the King Oyster Mushroom (
Pleurotus eryngii
)
Authors: Gao Qi , Liu Yu , Xie Jianbo , Zhao Shuang , Qin Wentao , Song Qinggang , Wang Shouxian , Rong Chengbo
Published: May 2022

Pleurotus eryngii
(king oyster mushroom) is a popular and economically valuable edible mushroom; however, it suffers from various bacterial diseases, including soft rot disease caused by the bacterium
Erwinia beijingensis
. Here, we examined bacterial infection of the mushroom through morphological and ultrastructural observations as well as transcriptome analysis.
Prevalence of Chromosomally Located
bla
CTX-M-55
in Salmonella Typhimurium ST34 Isolates Recovered from a Tertiary Hospital in Guangzhou, China
Authors: Zeng Shihan , Zhuo Zhenxu , Huang Yulan , Luo Jiajun , Feng Yulian , Gong Baiyan , Huang Xiyi , Wu Aiwu , Zhuo Chao , Li Xiaoyan
Published: May 2022

ESCs are the first choice for treating NTS infections. However, ESBLs and AmpC β-lactamases are the most typical cause for ESCs resistance.
Bazedoxifene, a Postmenopausal Drug, Acts as an Antimalarial and Inhibits Hemozoin Formation
Authors: Sudhakar Renu , Adhikari Navin , Pamnani Saniya , Panda Abhipsa , Bhattacharjee Manish , Rizvi Zeba , Shehzad Sadaf , Gupta Dinesh , Sijwali Puran Singh
Published: May 2022

The emergence and spread of drug-resistant strains of the human malaria parasite
Plasmodium falciparum
has necessitated new drugs. Selective estrogen receptor modulators are in clinical use for the prevention and treatment of breast cancer and postmenopausal osteoporosis.
Supplemental Material: Incipient collision of the Rae and Slave cratons at ca. 1.95 Ga
Authors: Cutts Jamie , Dyck Brendan
Published: May 2022

Text S1–S2; Figures S1–S11; Tables S1–S6.
Modeling of Electron Hole Transport within a Small Ribosomal Subunit
Authors: Sosorev A. Y.
Published: May 2022

Abstract—

Synchronized operation of various parts of the ribosome during protein synthesis implies the presence of a coordinating pathway, however, this is still unknown. We have recently suggested that such a pathway can be based on charge transport along the transfer and ribosomal RNA molecules and localization of the charges in functionally important areas of the ribosome. In the current study, using density functional theory calculations, we show that charge carriers (electron holes) can efficiently migrate within the central element of the small ribosomal subunit—the h44 helix. Monte-Carlo modeling revealed that electron holes tend to localize in the functionally important areas of the h44 helix, near the decoding center and intersubunit bridges. On the basis of the results obtained, we suggest that charge transport and localization within the h44 helix could coordinate intersubunit ratcheting with other processes occurring during protein synthesis.
Assessing the burden of COVID-19 in developing countries: systematic review, meta-analysis and public policy implications
Authors: Levin Andrew T , Owusu-Boaitey Nana , Pugh Sierra , Fosdick Bailey K , Zwi Anthony B , Malani Anup , Soman Satej , Besançon Lonni , Kashnitsky Ilya , Ganesh Sachin , McLaughlin Aloysius , Song Gayeong , Uhm Rine , Herrera-Esposito Daniel , de los Campos Gustavo , Peçanha Antonio Ana Carolina , Tadese Enyew Birru , Meyerowitz-Katz Gideon
Published: May 2022

Introduction

The infection fatality rate (IFR) of COVID-19 has been carefully measured and analysed in high-income countries, whereas there has been no systematic analysis of age-specific seroprevalence or IFR for developing countries.

Methods

We systematically reviewed the literature to identify all COVID-19 serology studies in developing countries that were conducted using representative samples collected by February 2021. For each of the antibody assays used in these serology studies, we identified data on assay characteristics, including the extent of seroreversion over time. We analysed the serology data using a Bayesian model that incorporates conventional sampling uncertainty as well as uncertainties about assay sensitivity and specificity. We then calculated IFRs using individual case reports or aggregated public health updates, including age-specific estimates whenever feasible.

Results

In most locations in developing countries, seroprevalence among older adults was similar to that of younger age cohorts, underscoring the limited capacity that these nations have to protect older age groups.

Age-specific IFRs were roughly 2 times higher than in high-income countries. The median value of the population IFR was about 0.5%, similar to that of high-income countries, because disparities in healthcare access were roughly offset by differences in population age structure.

Conclusion

The burden of COVID-19 is far higher in developing countries than in high-income countries, reflecting a combination of elevated transmission to middle-aged and older adults as well as limited access to adequate healthcare. These results underscore the critical need to ensure medical equity to populations in developing countries through provision of vaccine doses and effective medications.
Tumor-associated Tregs obstruct antitumor immunity by promoting T cell dysfunction and restricting clonal diversity in tumor-infiltrating CD8+ T cells
Authors: Noyes David , Bag Arup , Oseni Saheed , Semidey-Hurtado Jon , Cen Ling , Sarnaik Amod A , Sondak Vernon K , Adeegbe Dennis
Published: May 2022

Background

Accumulation of regulatory T cells (Treg) has been described to often correlate with poor prognosis in many solid tumors. How Treg presence impinges on limited functionality and clonal composition of tumor-associated CD8 +T cells has important implications for their therapeutic targeting in the tumor microenvironment. In the present study, we investigated how accumulation of Tregs contributes to T cell dysfunction and clonal constriction of tumor-infiltrating CD8 +T cells.

Methods

Resected melanoma and lung adenocarcinoma tissues from tumor-bearing mice or patients were analyzed. The proportions and phenotype as well as clonal diversity of tumor-associated CD8 +T cells were evaluated by flow cytometry and single-cell T-cell receptor (TCR) sequencing, respectively, at early or advanced tumor stages or under Treg depletion conditions. Furthermore, antigen-specific T cells were evaluated on adoptive transfer into tumor-bearing mice in the presence or absence of anti-CTLA-4 antibody or CTLA-4 Ig. Lastly, tumor-bearing mice were treated with anti-KLRG1 antibody and/or bromodomain inhibitor JQ1 with interleukin (IL)-2 immune complexes to determine therapeutic efficacy.

Results

We demonstrate that the emergence of exhaustion-like phenotype and impaired effector functionality in tumor-associated CD8 +T cells is positively correlated with Treg accumulation in the tumor bed and this dysfunctional phenotype becomes reversed on Treg reduction in murine melanoma and lung cancer models. Heightened tumor-associated Treg-expressed CTLA-4 is key to emergence and sustenance of this phenotype. Furthermore, TCR sequencing revealed a clonal shrinkage of tumor-infiltrating CD8 +T cells as tumor progressed, which was associated with reduced survival profile concomitant to increasing Treg proportions. Limited IL-2 availability was a key mechanism contributing to this peripheral repertoire reshaping as Treg depletion improved IL-2 levels, rescued CD8 +T cell viability, and improved their clonal diversity. Finally, targeted reduction of tumor but not peripheral Tregs through JQ1 and/or anti-KLRG1 antibody significantly improved antitumor response in melanoma-bearing mice when supplemented with IL-2 immune complexes.

Conclusion

Collectively, our study reveals a bimodal program enacted by Tregs to support T cell dysfunction in the tumor bed and highlights a promising therapeutic regimen for localized reprogramming of the tumor microenvironment to curb Treg impairment of antitumor CD8 +T cell response in favor of improved antitumor immunity.
Mechanism of effective combination radio-immunotherapy against 9464D-GD2, an immunologically cold murine neuroblastoma
Authors: Aiken Taylor J , Erbe Amy K , Zebertavage Lauren , Komjathy David , Feils Arika S , Rodriguez Matthew , Stuckwisch Ashley , Gillies Stephen D , Morris Zachary S , Birstler Jen , Rakhmilevich Alexander L , Sondel Paul M
Published: May 2022

Background

Most pediatric cancers are considered immunologically cold with relatively few responding to immune checkpoint inhibition. We recently described an effective combination radio-immunotherapy treatment regimen (combinationadaptive-innate immunotherapyregimen (CAIR)) targeting adaptive and innate immunity in 9464D-GD2, an immunologically cold model of neuroblastoma. Here, we characterize the mechanism of CAIR and the role of major histocompatibility complex class I (MHC-I) in the treatment response.

Methods

Mice bearing GD2-expressing 9464D-GD2 tumors were treated with CAIR (external beam radiotherapy, hu14.18-IL2 immunocytokine, CpG, anti-CD40, and anti-CTLA4) and tumor growth and survival were tracked. Depletion of specific immune cell lineages, as well as testing in immunodeficient R2G2 mice, were used to determine the populations necessary for treatment efficacy. Induction of MHC-I expression in 9464D-GD2 cells in response to interferon-γ (IFN-γ) and CAIR was measuredin vitroandin vivo, respectively, by flow cytometry and quantitative real-time PCR. A cell line with IFN-γ-inducible MHC-I expression (9464D-GD2-I) was generated by transfecting a subclone of the parental cell line capable of expressing MHC-I with GD2 synthase and was usedin vivoto assess the impact of MHC-I expression on responsiveness to CAIR.

Results

CAIR cures some mice bearing small (50 mm3) but not larger (100 mm3) 9464D-GD2 tumors and these cured mice develop weak memory responses against tumor rechallenge. Early suppression of 9464D-GD2 tumors by CAIR does not require T or natural killer (NK) cells, but eventual tumor cures are NK cell dependent. Unlike the parental 9464D cell line, 9464D-GD2 cells have uniformly very low MHC-I expression at baseline and fail to upregulate expression in response to IFN-γ. In contrast, 9464D-GD2-I upregulates MHC-I in response to IFN-γ and is less responsive to CAIR.

Conclusion

Treatment with CAIR cures 9464D-GD2 tumors in a NK cell dependent manner and induction of MHC-I by tumors cells was associated with decreased efficacy. These results demonstrate that the early tumor response to this regimen is T and NK cell independent, but that NK cells have a role in generating lasting cures in the absence of MHC-I expression by tumor cells. Further strategies to better inhibit tumor outgrowth in this setting may require further NK activation or the ability to engage alternative immune effector cells.
Association between thoracic epidural block and major complications after pleurectomy/decortication for malignant pleural mesothelioma under general anesthesia
Authors: Onoe Ken , Ogata Hiroki , Okamoto Takuma , Okutani Hiroai , Ueki Ryusuke , Kariya Nobutaka , Tatara Tsuneo , Hashimoto Masaki , Hasegawa Seiki , Matsuki Yuka , Hirose Munetaka
Published: May 2022

Introduction

A curative-intent surgical procedure, pleurectomy/decortication, for malignant pleural mesothelioma is accompanied by a high incidence of major postoperative complications. Although epidural block, which suppresses nociception during and after surgery, reportedly has both benefits and disadvantages in terms of outcomes after thoracic surgery for other diseases, the effects of epidural block on major complications after pleurectomy/decortication have not been evaluated. The aim of this study was to evaluate the association between epidural block and major postoperative complications following pleurectomy/decortication.

Methods

In a single-institutional observational study, consecutive adult patients undergoing pleurectomy/decortication under general anesthesia were enrolled from March 2019 to December 2021. Multivariable logistic regression analysis was performed to determine the association between perioperative variables and major complications. Next, patients were divided into two groups: general anesthesia with and without epidural block. Incidences of major postoperative complications, defined as Clavien-Dindo grades≥III, were compared between groups.

Results

In all patients enrolled with American Society of Anesthesiologists (ASA) physical status II or III (n=99), general anesthesia without epidural block was identified as a sole risk factor for major complications among perioperative variables. The incidence of major complications was 32.3% (95% CI 19.1% to 49.2%) in patients with epidural block (n=34), which was significantly lower than 63.1% (95% CI 50.9% to 73.8%) in patients without epidural block (n=65). In sensitivity analysis in patients with ASA physical status II alone, the same results were obtained.

Conclusion

Epidural block is likely associated with reduction of the incidence of major complications after pleurectomy/decortication for malignant pleural mesothelioma under general anesthesia.
Stitching Monte Carlo samples
Authors: Ehatäht Karl , Veelken Christian
Published: May 2022

Monte Carlo (MC) simulations are extensively used for various purposes in modern high-energy physics (HEP) experiments. Precision measurements of established Standard Model processes or searches for new physics often require the collection of vast amounts of data. It is often difficult to produce MC samples containing an adequate number of events to allow for a meaningful comparison with the data, as substantial computing resources are required to produce and store such samples. One solution often employed when producing MC samples for HEP experiments is to partition the phase space of particle interactions into multiple regions and produce the MC samples separately for each region. This approach allows to adapt the size of the MC samples to the needs of physics analyses that are performed in these regions. In this paper we present a procedure for combining MC samples that overlap in phase space. The procedure is based on applying suitably chosen weights to the simulated events. We refer to the procedure as “stitching”. The paper includes different examples for applying the procedure to simulated proton-proton collisions at the CERN Large Hadron Collider.
EFFECT OF DIFFERENT MIG WELDING MODES ON HARD-FACING OF INCONEL 718 ON 321 STAINLESS STEEL
Authors: ANBALAGAN KARPAGARAJ , SARALA R. , MANIVANNAN  , ROSEMARY SHOBIN LOUKKOSE , PRIYADARSHI HEMANT , CHEEPU MURALIMOHAN
Published: May 2022

In this study, the metal inert gas (MIG) welding process is taken to deposit the Inconel 718 material on 321 stainless steel. Various modes like the DC, DC-pulsed, and DC-wave-pulsed modes in MIG welding are used for depositing Inconel 718. The primary parameters such as the welding current (90–120 A) and speed (150–350 mm/min) are varied within the range for making the layer deposition over 321 stainless steel. After performing the layer deposition, the dilution, contact angle, and peak temperature are analyzed to find the optimal MIG welding mode. From the macrograph, very low dilution (7.44%) is identified for the DC mode. The most inferior contact angle ([Formula: see text]) of 49° was measured for the DC-wave-pulsed mode. The simulation work predicted a peak temperature of 2800°C for the DC mode. Considerable microstructure changes have occurred at the weld deposition (dendritic structure) and HAZ (grain coarsening) for all the three modes. At the top, interface, and HAZ locations, the microhardness obtained from the DC-pulsed mode is in between those of the DC and DC-wave-pulsed modes. Overall, the DC-pulsed mode is qualified for making the metal deposition and further work. For 50% overlap, defect-free 2-mm-thick layer depositions are made on the 321 stainless steel surfaces.
A Look at the Focus on Big Data for Information Technology and Decision Making During 1994 to 2020
Authors: Xu Zeshui , Ge Zijing , Wang Xinxin , Kou Gang
Published: May 2022

Big data starts booming in 2013 and has multiple applications in all walks of life. In such an environment, big data for information technology (BDI) and decision making (BDD) have formed some hot topics in common. This paper reviews the body of BDI and BDD research studies from 1994 to 2020, using bibliometrics analysis. The aim of this paper is to explore the current status, the correlation between BDI and BDD, the future trends and challenges. From time and space dimensions, CiteSpace and VOS viewer are used to obtain the annual trends of documents, the distribution of countries and sources, the citations and the h-index of BDI and BDD. The top three productive countries are the USA, China and the UK. From the perspective of h-index, the USA and the UK are at the forefront of the world. The value of big data is realized through information acquisition, storage, analysis, expression transmission and service sharing technologies, and the decision-making techniques exist throughout the process of big data analysis. “Business” and “Information science library science” are the latest hotspots of BDI. The appliances in the organization, supply chain management, education, and the environment are recent themes of BDD. Big data technology processing capabilities and network security issues are the main challenges in the future. This study contributes to the body of knowledge on BDI and BDD, and hops to help in understanding the evolution of them in relevant fields.
Design and Performance of a LARMbot PK Arm Prototype
Authors: Fort Axel , Laribi Med Amine , Ceccarelli Marco
Published: May 2022

This paper presents design and performance of a prototype of new humanoid arm that has been developed at the LARM2 laboratory of the University of Rome “Tor Vergata”. This new arm, called LARMbot PK arm, is an upper limb that is designed for the LARMbot humanoid robot. LARMbot is a humanoid robot designed to move freely in open spaces, and able to adapt to task environment. Its objective is to transport objects weighing a few kilograms in order to facilitate the restocking of workstations, or to manage small warehouses and other tasks feasible for humanoids. The LARMbot PK arm is conceived as a solution that is designed on the basis of a parallel tripod structure using linear actuators to provide high agility of movement. This solution is designed with components that can be found on the market or can be created by 3D printing in order to offer a quality and price ratio well convenient for user-oriented humanoid robots. Experimental tests are discussed with the built prototype to demonstrate the capabilities of the proposed solution in terms of agility, autonomy, and power to validate the LARMbot PK arm solution as a satisfactory solution for the new upper limbs of the LARMbot humanoid robot.
Co(III)-tetra(4-sulfonatophenyl)porphyrin complexes with bidentate ligands in aqueous buffer media
Authors: Kaigorodova Elena Yu. , Mamardashvili Galina M. , Mamardashvili Nugzar Z.
Published: May 2022

The processes of hydrophilic Co(III)-tetra(4-sulfonatophenyl)porphyrin supramolecular assembly with 4,4-bipyridyl in aqueous buffer media have been studied by UV-vis, 1D and 2D 1H NMR-spectroscopy. In the case of 1,4-diazabicyclo[2.2.2]octane, pyrazine and piperazine in aqueous solutions, no assembly was observed. Interactions of the hydrophilic Co(III)-tetraarylporphyrin with ionic micelles (cationic surfactants with different alkyl tail lengths) in buffer media were investigated. These studies were performed by the UV-vis, 1D NOESY-spectroscopy and dynamic lightscattering (DLS) methods. The metalloporphyrins were incorporated into the hydrophobic part of micelles, which led to Co(III) reduction to Co(II) in the Co-porphyrinate composition. The rate of Co(III) reduction accompanied by detachment of additional ligands coordinated on Co(III)-porphyrins or disruption of supramolecular dimers and depends on the surfactant concentration and nature. The results obtained indicate the possibility of creating supramolecular porphyrin-based assemblies with the preprogrammed lifetime (from several hours to several days) and could be used in the creation of host-guest systems for recognition, selective binding and the prolonged release of bioactive substrates as the means in the designing of biomimetic systems with effective binding affinities to heterocycles, DNA base pairs and RNA.
Some properties of isoclinism in n-Lie superalgebras
Authors: Padhan Rudra Narayan , Nandi Nupur , Pati Kishor Chandra
Published: May 2022

In this paper, we define isoclinism of [Formula: see text]-Lie superalgebras of parity [Formula: see text] and study some of its properties. Furthermore, we prove that notion of isoclinism and isomorphism of two finite dimensional [Formula: see text]-Lie superalgebras of same parity are equivalent.
On multi-valued version of M-iteration process
Authors: Ullah Kifayat , Ahmad Junaid , Khan Abdul Rahim
Published: May 2022

We give a multi-valued version of M iterative process [K. Ullah and M. Arshad, Numerical reckoning fixed points Suzuki’s generalized nonexpansive mappings via new iteration process, Filomat 32 (2018) 187–196] in the setting of Banach spaces. After this, we prove some weak and strong convergence results for the class of multi-valued quasi-nonexpansive mappings (which contains the class of multi-valued nonexpansive mappings) with proper numerical examples using multi-valued version of M-iteration process. These results generalize several well-known comparable results in the literature.
On construction of certain Fischer embedded subgroups generated by 3-transpositions in Fi22
Authors: Bani-Ata Mashhour
Published: May 2022

In this paper, we investigate the Fischer group [Formula: see text]. This group is generated by a conjugacy class of involutions, any non-commuting pair of which has product of order 3. Such involutions are called transpositions and their conjugacy class is denoted by D. Subgroups generated by elements of D are called D-groups as they have been called by Enright [G. M. Enright, The structure and subgroups of the Fischer groups [Formula: see text] and [Formula: see text], Ph.D. thesis, University of Cambridge (1976)], Fischer embedded or 3-transposition groups. Here, we obtain the following main results:

• The rank of the groups [Formula: see text], the Weyl group W of type [Formula: see text] over fields of characteristic 2, the group M of shape [Formula: see text] and the group [Formula: see text] are computed. If G is a 3-transposition group (Fischer embedded) for a class [Formula: see text] of transpositions, then [Formula: see text] is defined as [Formula: see text], all elements in X commute[Formula: see text]. • We prove that the subgroups [Formula: see text] and [Formula: see text] are Fischer embedded and we give an explicit construction for them. It is remarkable to mention that Enright studied certain D-groups under a very strong condition that is [Formula: see text] and [Formula: see text] where G is the group generated by a proper subset E of D, [Formula: see text] is the derived subgroup of G and E is a single conjugacy class in G. Our study will be carried out without such conditions.
Cyclotomy, cyclotomic cosets and arithmetic properties of some families in 𝔽l[x] 〈xptq−1〉
Authors: Kumar Kapil , Batra Sudhir
Published: May 2022

Arithmetic properties of some families in [Formula: see text] and hence in [Formula: see text] are obtained by using the cyclotomic classes of order 2 with respect to [Formula: see text], where [Formula: see text] is primitive root modulo [Formula: see text], [Formula: see text] and [Formula: see text]. The form of these cyclotomic classes enables us to generalize the results obtained in [S. Jain and S. Batra, Cyclotomy and arithmetic properties of some families in [Formula: see text], Asian-Eur. J. Math. 13(4) (2020) 2050077].
A note on Hölder-type inequality
Authors: Castillo René Erlin , Pec̆arić Josip
Published: May 2022

In this paper, a Hölder-type inequality due to L. C. Young is considered. Improvement and generalizations of this inequality are given.
Atomistic nanoindentation study of Al–Mg intermetallic compounds based on molecular dynamics simulation
Authors: Chabba Hanae , Taoufiki Meryem , Barroug Abdrahim , Jouaiti Ahmed , Dafir Driss
Published: May 2022

In this paper, a 3D molecular dynamics (MD) simulation is performed to investigate the nanoindentation process, the most frequently used technique to measure mechanical properties such as hardness, of three Al/Mg intermetallic compounds, where Mg is the main element added to pure Al. To further improve the understanding of the mechanical response, in this study, we examine the hardness-strength data for three kinds of typical materials, including [Formula: see text]-Al3Mg2 and [Formula: see text]-[Formula: see text][Formula: see text] and [Formula: see text]-[Formula: see text][Formula: see text] phases with different microstructures. In terms of the observed morphologies around the indentations, the influencing variables of the general link between strength and hardness are described. Accordingly, atomic simulations in this paper are performed under the same loading ([Formula: see text]) using a spherical diamond indenter. At both the [Formula: see text]-[Formula: see text][Formula: see text] and [Formula: see text]-[Formula: see text][Formula: see text] phases, we can see that the indenter generates a bigger deformation zone and a greater number of dislocations in the [Formula: see text] direction. The simulation findings show that the microstructure has an impact on the shape of the deformation in each phase. After the deformation process, we get the depth-displacement ([Formula: see text]–[Formula: see text]) curves to describe the mechanical behavior of [Formula: see text]-Al3Mg2, [Formula: see text]-[Formula: see text][Formula: see text] and [Formula: see text]-[Formula: see text][Formula: see text] phases. From the [Formula: see text]–[Formula: see text] curves, we got the radial distribution function, mechanical properties, such as micro hardness, Yield point and maximum load are determined and presented. According to the findings, the chemical composition of these phases has a considerable impact on their characteristics. These [Formula: see text]–[Formula: see text] curves obtained show a rapid increase in loading up to a maximum. The deformation behavior of −Al3Mg2 and −[Formula: see text][Formula: see text] phases under nanoindentation is slightly identical, and they have also a high elasticity limit, the ability to endure deformation and the characteristic of being very ductile and malleable. While [Formula: see text]-[Formula: see text][Formula: see text] phase was shown to be brittle and weak under the same uniaxial nanoindentation loading compared to other phases, it was found that there is a good correlation between the previous simulated studies.
An Efficient CNN Accelerator for Low-Cost Edge Systems
Authors: Choi Kyubaik , Sobelman Gerald E.
Published: May 2022

Customized hardware based
convolutional neural network
(
CNN
or
ConvNet
) accelerators have attracted significant attention for applications in a low-cost, edge computing system. However, there is a lack of research that seeks to optimize at both the algorithm and hardware levels simultaneously in resource-constrained FPGA systems. In this paper, we first analyze ConvNet models to find one that is most suitable for a low-cost FPGA implementation. Based on the analysis, we select MobileNetV2 as the backbone of our research due to its hardware-friendly structure. We use a quantized implementation with 4-bit precision and optimize further with a smaller input resolution of 192 × 192 to obtain a 68.8% detection accuracy on ImageNet, which represents only a 3.2% accuracy loss compared to a floating-point model that uses the full input size. We then develop a hardware implementation that uses a low-cost FPGA. To accelerate the depth-wise separable ConvNet and utilize DRAM resources efficiently with parallel processing, we propose a novel scoreboard architecture to dynamically schedule DRAM data requests in order to maintain a high hardware utilization. The number of DSP blocks used is about six times smaller than in prior work. In addition, internal block RAM utilization is approximately nine times more efficient than in prior work. Our proposed design achieves 3.07
frames per second (FPS)
on the low-cost and resource constrained FPGA system.
Spontaneous Facial Behavior Analysis Using Deep Transformer-based Framework for Child–computer Interaction
Authors: Qayyum Abdul , Razzak Imran , Tanveer M. , Mazher Moona
Published: May 2022

A fascinating challenge in robotics-human interaction is imitating the emotion recognition capability of humans to robots with the aim to make human-robotics interaction natural, genuine and intuitive. To achieve the natural interaction in affective robots, human-machine interfaces, and autonomous vehicles, understanding our attitudes and opinions is very important, and it provides a practical and feasible path to realize the connection between machine and human. Multimodal interface that includes voice along with facial expression can manifest a large range of nuanced emotions compared to purely textual interfaces and provide a great value to improve the intelligence level of effective communication. Interfaces that fail to manifest or ignore user emotions may significantly impact the performance and risk being perceived as cold, socially inept, untrustworthy, and incompetent. To equip a child well for life, we need to help our children identify their feelings, manage them well, and express their needs in healthy, respectful, and direct ways. Early identification of emotional deficits can help to prevent low social functioning in children. In this work, we analyzed the child’s spontaneous behavior using multimodal facial expression and voice signal presenting multimodal transformer-based last feature fusion for facial behavior analysis in children to extract contextualized representations from RGB video sequence and Hematoxylin and eosin video sequence and then using these representations followed by pairwise concatenations of contextualized representations using cross-feature fusion technique to predict users emotions. To validate the performance of the proposed framework, we have performed experiments with the different pairwise concatenations of contextualized representations that showed significantly better performance than state-of-the-art method. Besides, we perform t-distributed stochastic neighbor embedding visualization to visualize the discriminative feature in lower dimension space and probability density estimation to visualize the prediction capability of our proposed model.
Analytical and Numerical Analysis of Lithium Plating Onset in Single and Bilayer Graphite Electrodes during Fast Charging
Authors: Mijailovic Aleksandar S. , Wang Guanyi , Li Yejing , Yang Jian , Lu Wenquan , Wu Qingliu , Sheldon Brian W.
Published: May 2022

Lithium plating is commonly observed in anodes charged at fast rates, and can lead to capacity loss and battery safety issues. The increased risk of plating has been attributed to transport limitations, and architectured electrodes may reduce plating risk. However, while theoretical studies have shown that reaction non-uniformity arises due to interplay of transport limitations, anode open circuit voltage behavior and reaction kinetics, its effect on lithium plating has not been studied. We use analytic and numerical simulations to predict onset of plating in graphite anode half-cells at high C-rates and demonstrate how anodes with layered porosities can delay plating. Simplified analytical models identify trends for plating onset and predictions are calibrated against numerical models. A calibrated numerical model of graphite demonstrates qualitative agreement with analytical model predictions. This reaction inhomogeneity mechanism occurs in the absence of lithium ion depletion, indicating that these mechanisms may contribute to capacity loss independently or simultaneously. A bilayer model of graphite exhibits delayed plating onset, and an optimization procedure is presented. This theoretical work presents quantitative and mechanistic insight on how reaction inhomogenity affects lithium metal plating onset and can be used as a guide to engineer anodes resistant to lithium plating.
Influence of Silver Nanoparticles on Dielectric Properties of Human Blood
Authors: Gaur Mulayam Singh , Saran Dayal , Sagar Rohan , Sisodia Kamlesh , Gaur Karuna , Indolia Ajay Pal
Published: May 2022

The dielectric properties of human blood are studied using dielectric spectroscopy. The silver nanoparticles (AgNPs) of 50 nm were chemically synthesized using tri-sodium citrate as a reducing agent. Different amount of AgNPs were mixed carefully in fresh human blood of healthy person. The micrographs of blood were recorded before and after addition of nanoparticles. Micrograph shows the contraction of erythrocytes after injection of AgNPs. The contraction of erythrocytes increases with increase of AgNPs concentration. The observed permittivity, tangential loss, impedance decayed with frequency and then constant at higher frequency range. However, tangential loss and impedance shows S shape characteristics. i) silver nanoparticles directly affects the dielectric parameters of human blood; ii) effects are more relevant at frequencies below the MHz and; iii) the influence on the dielectric parameters is less with low concentration of AgNPs. The experimental finding of this heterogeneous system indicates α, β and Maxwell Wagner type of dispersion control the dielectric properties of whole human blood in the frequency range of 42 Hz to 20 kHz at 30 °C.
Activity of pontine A7 noradrenergic neurons is suppressed during REM sleep
Authors: Fenik Victor B. , Rukhadze Irma
Published: May 2022

Noradrenergic A7 neurons are mostly silent during REM sleep. This is in accord with their role in the control of upper airway muscles and important contribution to OSA pathophysiology. Therefore, a modulation of A7 neuron activity can serve as a novel therapeutic target for pharmacological treatment of OSA.
Performance Evaluation of Ethiopian Bread Wheat (Triticum aestivum L.) Genotypes in Southern Ethiopia
Authors: Alambo Mengistu Meskele , Gessese Mesfin Kebede , Wachamo Eyasu Wada , Melo Belay Yebo , Lakore Zemach Sorsa , Wassie Adera Sisay , Haile Wondimeneh Taye , Kassie Fentanesh Chekole
Published: May 2022

Ethiopia is not self-sufficient to meet its increasing wheat demand from domestic production partly due to a lack of improved seeds. Efforts are undertaken to fill the gap through off-season production of wheat using supplemental irrigation and modern cultivars adapted to arid areas. This study was carried out to evaluate the genetic variability and adaptability of 15 Ethiopian bread wheat genotypes at different agroecologies in Wolaita and Dawuro zones, Ethiopia. The field experiment was conducted at three locations using a randomized complete block design with three replications during the 2019/2020 main cropping season. Analysis of variance based on 11 morphological agronomic traits and two major wheat diseases revealed that there were highly significant differences (

P
<
0.01

) among the genotypes for all the traits studied at each location and combined over locations. The top three cultivars viz. Alidoro, Galema, and Honqolo exhibited higher average grain yield (GY) of 4.54 t/ha, 4.36 t/ha, and 4.0 t/ha, respectively, combined over locations. Eight of the traits (72.73%) exhibited moderate (30–60%) to high broad-sense heritability (

h
b
2

 > 60%) values. High

h
b
2

associated with high genetic advance as percent of mean was observed for the severity of both stem and yellow rust diseases combined over locations. GY was significantly related to aboveground biomass at all locations. This study depicted that cultivar Alidoro had wider adaptability for grain yield and resistance to wheat rusts.
Pulmonary Nodule Clinical Trial Data Collection and Intelligent Differential Diagnosis for Medical Internet of Things
Authors: Wu Weijia , Gu Lizhong , Zhang Yuefeng , Huang Xianping , Zhou Weihe
Published: May 2022

In this paper, the medical Internet of things (IoT) is used to pool data from clinical trials of pulmonary nodules, and on this basis, intelligent differential diagnosis techniques are investigated. A filtered orthogonal frequency division multiplexing model based on polarisation coding is proposed, where the input data are fed to a modulator after polarisation cascade coding, and the system performance is analysed under a medical Internet of things modulated additive Gaussian white noise channel. The above polarisation‐coded filtered orthogonal frequency division multiplexing system components are applied to electroencephalogram (EEG) signal transmission, to which a threshold compression module and a vector reconstruction module are added to address the system power burden associated with the acquisition and transmission of large amounts of real‐time EEG data in the medical IoT. In the threshold compression module, the inherent characteristics of EEG signals are analysed, and the generated EEG data are decomposed into multiple symbolic streams and compressed by applying different thresholds to improve the compression ratio while ensuring the quality of service of the application. A deep neural network‐based approach is proposed for the detection and diagnosis of lung nodules. Automatic identification and measurement of simulated lung nodules and the corresponding volumes of nodules in images under different conditions are applied. The sensitivity of each AIADS in identifying lung nodules under different convolution kernel conditions, false positives (FP), false negatives (FN), relative volume errors (RVE), the miss detection rate (MDR) for different types of lung nodules, and the performance of each system in predicting the four types of nodules are calculated. In this paper, an interpretable multibranch feature convolutional neural network model is proposed for the diagnosis of benign and malignant lung nodules. It is demonstrated that the proposed model not only yields interpretable lung nodule classification results but also achieves better lung nodule classification performance with an accuracy rate of 97.8%.