bluuebunny/crossref_metadata_2025 huggingface dataset:
An evaluation of adverse events following an immunization campaign with the live, attenuated SA14-14-2 Japanese encephalitis vaccine in Cambodia
Authors: Hills Susan L. , Soeung Sann Chan , Sarath Svay , Morn Chheng , Dara Cheam , Fischer Marc , Thigpen Michael C.
Published: June 2022

Introduction

Japanese encephalitis (JE) virus is the most common cause of vaccine-preventable encephalitis in Asia. The SA14-14-2 JE vaccine manufactured by Chengdu Institute of Biological Products has been shown to be safe and effective in clinical trials and childhood routine immunization programs. However, there are few published reports describing results of surveillance for adverse events following immunization (AEFI) when the vaccine is used in mass campaigns. We describe the results of AEFI surveillance following a 2013 vaccination campaign among almost 310,000 children aged 9 months–12 years in Battambang Province, Cambodia.

Methods

Routine AEFI surveillance was strengthened by staff training and supplemented by active hospital surveillance. An AEFI was defined as any sign, symptom, or disease temporally associated (i.e., within 4 weeks) with receipt of the vaccine, irrespective of whether it was considered related to immunization. Data were collected on standardized forms and causality assessments were conducted for serious AEFI.

Results

Passive and active surveillance detected 28 AEFI for an overall incidence of 9.0 AEFI per 100,000 doses administered. The most frequent events were vasovagal episodes (n = 7, 25%) and rash (n = 6, 21%), and most other events were common childhood conditions such as fever and vomiting. Three AEFI were classified as serious, including one hypersensitivity reaction and two meningoencephalitis cases. Of these, the hypersensitivity event was the only serious AEFI classified as being consistent with a causal association to immunization.

Conclusions

Most reported adverse events were conditions that commonly occur after other childhood vaccinations or independently of vaccination, and in the context of careful monitoring for serious AEFI only one serious event consistent with a causal association with immunization was identified. These results support the good safety profile of the SA14-14-2 JE vaccine, and provide reassuring data as the vaccine’s use expands.
A three-dimensional (3D), serum-free, Collagen Type I system for chondrogenesis of canine bone marrow-derived multipotent stromal cells (cMSCs)
Authors: MacIver Melissa A. , Dobson Lauren K. , Gregory Carl A. , Muneoka Ken , Saunders W. Brian
Published: June 2022

The dog is an underrepresented large animal translational model for orthopedic cell-based tissue engineering. While chondrogenic differentiation of canine multipotent stromal cells (cMSCs) has been reported using the classic micromass technique, cMSCs respond inconsistently to this method. The objectives of this study were to develop a three-dimensional (3D), serum-free, Collagen Type I system to facilitate cMSC chondrogenesis and, once established, to determine the effect of chondrogenic growth factors on cMSC chondrogenesis. Canine MSCs were polymerized in 100 μL Collagen Type I gels (5 mg/mL) at 1 x 106 cells/construct. Constructs were assessed using morphometry, live/dead staining, and histology in 10 various chondrogenic media. Four media were selected for additional in-depth analyses via lactate dehydrogenase release, total glycosaminoglycan content, qPCR (COL1A1, COL2A, SOX9, ACAN, BGLAP and SP7), immunofluorescence, and TUNEL staining. In the presence of dexamethasone and transforming growth factor-β3 (TGF-β3), both bone morphogenic protein-2 (BMP-2) and basic fibroblast growth factor (bFGF) generated larger chondrogenic constructs, although BMP-2 was required to achieve histologic characteristics of chondrocytes. Chondrogenic medium containing dexamethasone, TGF-β3, BMP-2 and bFGF led to a significant decrease in lactate dehydrogenase release at day 3 and glycosaminoglycan content was significantly increased in these constructs at day 3, 10, and 21. Both osteogenic and chondrogenic transcripts were induced in response to dexamethasone, TGF-β3, BMP-2 and bFGF. Collagen Type II and X were detected in all groups via immunofluorescence. Finally, TUNEL staining was positive in constructs lacking BMP-2 or bFGF. In conclusion, the 3D, serum-free, Collagen Type-I assay described herein proved useful in assessing cMSC differentiation and will serve as a productive system to characterize cMSCs or to fabricate tissue engineering constructs for clinical use.
Quality assurance practices in tuberculosis diagnostic health facilities in Ethiopia
Authors: Abebaw Yeshiwork , Kebede Abebaw , Eshetu Kirubel , Tesfaye Ephrem , Tadesse Mengistu , Sinshaw Waganeh , Amare Misiker , Gamtesa Dinka Fikadu , Zerihun Betselot , Getu Melak , Seid Getachew , Yalew Anteneh , Diriba Getu
Published: June 2022

Introduction

The quality of tuberculosis laboratory services in health facilities is a mandatory component of detecting active pulmonary TB cases and treatment follow-up. However, ensuring the quality of laboratory test results is a concern. This study aimed to assess the quality assurance practices in the tuberculosis diagnostic health facilities of Ethiopia.

Materials and methods

A cross-sectional study was conducted from October 2018 to March 2019 at nine governmental TB-culture laboratories and 34 randomly selected GeneXpert® MTB/RIF (Xpert® MTB/RIF) testing health facilities in Ethiopia. Participating health facilities were interviewed and laboratory documents and records present since 2017 were observed. Prior to the data collection, training was given to the data collectors. Descriptive statistics were used to produce results and were presented with tables and graphs.

Results

From a total of 34 Xpert® MTB/RIF testing laboratories, 50% run Internal Quality Control (IQC) for Acid-Fast Bacillus (AFB) Microscopy and 67.6% had lot-to-lot verification of staining reagents. For the Xpert® MTB/RIF assay, a lot-to-lot verification of cartridge and method validation was performed only in 8.8%and 20.6% of Xpert® MTB/RIF testing laboratories respectively. All TB-culture laboratories included in the study ran negative control (start and end IQC) during TB-culture sample processing and performed lot-to-lot verification for Mycobacteria Growth Indicator Tube (MGIT) in 88.9% of TB-culture laboratories. External Quality Assessment (EQA) Proficiency Testing (PT) for AFB microscopy is practiced in 79.4% Xpert® MTB/RIF testing laboratories and 100.0% for the Xpert® MTB/RIF assay. TB-Culture PT participation practice among TB-culture laboratories was 88.9%. A major challenge for health facilities during PT participation was the AFB PT-sample transportation delay (40.7%) and the Xpert® MTB/RIF assay EQA-PT feedback missing (38.2%).

Conclusion

This assessment reveals that IQC for AFB microscopy, lot-to-lot verification, method validation, and equipment calibration were not well-practiced. The majority of TB diagnostic health facility laboratories had EQA-PT participation practice, but a significant gap in PT-sample transportation and missing feedback was identified.
Simulating two-sided mobility platforms with MaaSSim
Authors: Kucharski Rafał , Cats Oded
Published: June 2022

Two-sided mobility platforms, such as Uber and Lyft, widely emerged in the urban mobility landscape. Distributed supply of individual drivers, matched with travellers via intermediate platform yields a new class of phenomena not present in urban mobility before. Such disruptive changes to transportation systems call for a simulation framework where researchers from various and across disciplines may introduce models aimed at representing the complex dynamics of platform-driven urban mobility. In this work, we present MaaSSim, a lightweight agent-based simulator reproducing the transport system used by two kinds of agents: (i) travellers, requesting to travel from their origin to destination at a given time, and (ii) drivers supplying their travel needs by offering them rides. An intermediate agent, the platform, matches demand with supply. Agents are individual decision-makers. Specifically, travellers may decide which mode they use or reject an incoming offer; drivers may opt-out from the system or reject incoming requests. All of the above behaviours are modelled through user-defined modules, allowing to represent agents’ taste variations (heterogeneity), their previous experiences (learning) and available information (system control). MaaSSim is a flexible open-source python library capable of realistically reproducing complex interactions between agents of a two-sided mobility platform. MaaSSim is available from a public repository, along with a set of tutorials and reproducible use-case scenarios, as demonstrated with a series of illustrative examples and a comprehensive case study.
Dispositional optimism and business recovery during a pandemic
Authors: Amore Mario , Garofalo Orsola , Martin-Sanchez Victor
Published: June 2022

A large literature at the crossroads of biology and cognitive psychology has shown that individuals hold generally positive expectations about future events. Despite this evidence, to date it remains unclear whether optimism has positive or negative implications for entrepreneurial activities. We examine this question in the context of the Covid-19 pandemic, which provides a unique way to study the role of optimism on the (in)ability of firms to overcome exogenous shocks. Using a large-scale longitudinal survey covering 1,632 UK firms, we find that entrepreneurs who score high on optimism were more likely to innovate and make organizational changes to their firms during the Covid-19 outbreak. Moreover, optimistic entrepreneurs experienced higher revenue growth during the pandemic. Collectively, our study sheds light on one of the psychological factors explaining why some firms can prosper and some others struggle in the wake of an external shock.
Emergence of power and complexity in obstetric teamwork
Authors: Neuhaus Christopher , Lutnæs Dag Erik , Bergström Johan
Published: June 2022

Background

Recently, increasing attention has been paid to team processes in peripartum care settings with the aim to improve fetomaternal outcomes. However, we have yet to understand how the perception of teamwork in peripartum care is shaped in a complex, multi-disciplinary environment.

Methods

The aim of this study was to approach the question using qualitative social-scientific methodology. The theoretical foundation of the study was that obstetric teamwork is the result of a balancing act in which multiple goal conflicts are continuously negotiated and managed right at the boundary of acceptable performance in a complex adaptive system. We explored this theory by gathering lived experiences of successful management of peripartum emergencies. Based on our analysis we generated an understanding of teamwork as a phenomenon emerging from interpersonal relationships, complex relations of power, and the enactment of current quality management practices.

Results

Caregivers define teamwork through the quality of their collaboration, defined by respect and appreciation, open communication, role distribution, and shared experiences. However, teamwork also becomes the framework for negotiation of many conflicts that originated elsewhere. Power was the core theme that emerged in the analysis of our participants’ narratives, which is in stark contrast to the otherwise promoted egalitarian rhetoric of team training. While our participants generally reverted to explanations based on their professional identities, traditions or cultures, interesting dynamics become visible when work is viewed through the power lens.

Conclusions

Our study paints the convoluted picture of a work environment with all its intricacies, constraints, interpersonal relations and hierarchical struggles that are much more representative of a complex system rather than the easily tractable environment that so many stakeholders would like healthcare practitioners to believe in. The issue of power emerged as a decisive factor in the social dynamics at the workplace, revealing hidden agendas in the teamwork discourse.
Association between plaque vulnerability and neutrophil extracellular traps (NETs) levels: The Plaque At RISK study
Authors: de Vries Judith J. , Autar Anouchska S. A. , van Dam-Nolen Dianne H. K. , Donkel Samantha J. , Kassem Mohamed , van der Kolk Anja G. , van Velzen Twan J. , Kooi M. Eline , Hendrikse Jeroen , Nederkoorn Paul J. , Bos Daniel , van der Lugt Aad , de Maat Moniek P. M. , van Beusekom Heleen M. M.
Published: June 2022

Carotid atherosclerotic plaque rupture and its sequelae are among the leading causes of acute ischemic stroke. The risk of rupture and subsequent thrombosis is, among others, determined by vulnerable plaque characteristics and linked to activation of the immune system, in which neutrophil extracellular traps (NETs) potentially play a role. The aim of this study was to investigate how plaque vulnerability is associated with NETs levels. We included 182 patients from the Plaque At RISK (PARISK) study in whom carotid imaging was performed to measure plaque ulceration, fibrous cap integrity, intraplaque hemorrhage, lipid-rich necrotic core, calcifications and plaque volume. Principal component analysis generated a ‘vulnerability index’ comprising all plaque characteristics. Levels of the NETs marker myeloperoxidase-DNA complex were measured in patient plasma. The association between the vulnerability index and low or high NETs levels (dependent variable) was assessed by logistic regression. No significant association between the vulnerability index and NETs levels was detected in the total population (odds ratio 1.28, 95% confidence interval 0.90–1.83, p = 0.18). However, in the subgroup of patients naive to statins or antithrombotic medication prior to the index event, this association was statistically significant (odds ratio 2.08, 95% confidence interval 1.04–4.17, p = 0.04). Further analyses revealed that this positive association was mainly driven by intraplaque hemorrhage, lipid-rich necrotic core and ulceration. In conclusion, plaque vulnerability is positively associated with plasma levels of NETs, but only in patients naive to statins or antithrombotic medication prior to the index event.
Quantitative regulation of the thermal stability of enveloped virus vaccines by surface charge engineering to prevent the self-aggregation of attachment glycoproteins
Authors: Shang Yu , Li Li , Zhang Tengfei , Luo Qingping , Yu Qingzhong , Zeng Zhe , Li Lintao , Jia Miaomiao , Tang Guoyi , Fan Sanlin , Lu Qin , Zhang Wenting , Xue Yuhan , Wang Hongling , Liu Wei , Wang Hongcai , Zhang Rongrong , Ding Chan , Shao Huabin , Wen Guoyuan
Published: June 2022

The development of thermostable vaccines can relieve the bottleneck of existing vaccines caused by thermal instability and subsequent poor efficacy, which is one of the predominant reasons for the millions of deaths caused by vaccine-preventable diseases. Research into the mechanism of viral thermostability may provide strategies for developing thermostable vaccines. Using Newcastle disease virus (NDV) as model, we identified the negative surface charge of attachment glycoprotein as a novel determinant of viral thermostability. It prevented the temperature-induced aggregation of glycoprotein and subsequent detachment from virion surface. Then structural stability of virion surface was improved and virus could bind to and infect cells efficiently after heat-treatment. Employing the approach of surface charge engineering, thermal stability of NDV and influenza A virus (IAV) vaccines was successfully improved. The increase in the level of vaccine thermal stability was determined by the value-added in the negative surface charge of the attachment glycoprotein. The engineered live and inactivated vaccines could be used efficiently after storage at 37°C for at least 10 and 60 days, respectively. Thus, our results revealed a novel surface-charge-mediated link between HN protein and NDV thermostability, which could be used to design thermal stable NDV and IAV vaccines rationally.
Aproximaciones a la poesía española a principios del siglo XXI: nuevos nombres y ¿nuevas poéticas?
Authors: Molina Gil Raúl
Published: June 2022

En torno al año 2000, los principales críticos y antólogos trataron de referir que el cambio de milenio implicaría una modificación en las estructuras del campo poético español. Fueron muchas las publicaciones que marcaron ese rumbo y muy explícito fue el intento de encontrar un nuevo poeta de referencia en torno al cual se aglutinara la creación más contemporánea. Sin embargo, y a pesar de los esfuerzos, los viejos modelos generacionales comenzaron a quedar obsoletos ante un panorama distanciado de la tradicional retórica de la ruptura que había estructurado el discurso histórico de la poesía española. La cuestión aquí, por tanto, es tratar de definir si en los nuevos nombres (aquellos y aquellas que comenzaron a publicar justo antes o inmediatamente después del 2000) podemos encontrar nuevas poéticas cuya emergencia fue vaticinada por la crítica o si, por el contrario, dichos autores continuaron la senda marcada por sus predecesores.
Representaciones teatrales en Castilla-La Mancha desde 1585 hasta 1699
Authors: Gómez Caballero Iván
Published: June 2022

El presente trabajo trata de definir el panorama teatral de Castilla-La Mancha desde finales del siglo XVI hasta el siglo XVII a partir de bibliografía especializada y también gracias a las bases de datos CATCOM y DICAT de la Universidad de Valencia, ahondando en varios aspectos, como, por ejemplo, los autores más representados, así como las localidades y las provincias que debieron tener más actividad teatral.
Prieto de Paula, Ángel L. La poesía española de la II República a la Transición. Alicante: Universidad de Alicante, 2021, 845 pp., ISBN: 978-84-9717-746-7
Authors: Bagué Quílez Luis
Published: June 2022

Reseña del libro: Prieto de Paula, Ángel L. La poesía española de la II República a la Transición. Alicante: Universidad de Alicante, 2021, 845 pp., ISBN: 978-84-9717-746-7.
Vulnerabilidade à Poluição Antropogênica no Sistema Aquífero Dunas/Barreiras da Região Metropolitana de Natal
Authors: Madroñero Felix David Rivera , Oliveira Felipe Silva , Souza Raquel Franco , Navoni Júlio Alejandro
Published: June 2022

Tradicionalmente, as águas subterrâneas têm sido consideradas protegidas pelo subsolo. No entanto, o descarte de poluentes estáveis ​​em zonas de infiltração favorável pode gerar contaminação do recurso hídrico, colocando em risco a saúde da população. Para solucionar a crescente contaminação de aquíferos por atividades antrópicas, a avaliação de vulnerabilidade é um dos requisitos fundamentais para gerar diretrizes, estratégias e políticas de prevenção e minimização da contaminação de águas subterrâneas. O presente estudo tem como objetivo avaliar a vulnerabilidade à poluição antropogênica nos aquíferos da Região Metropolitana de Natal. Nesta pesquisa foi utilizado o método GODS (Grau de confinamento, Ocorrência de substrato litológico, Distância da superfície do terreno ao nível da água subterrânea e tipo de Solo), que propõe um cálculo da vulnerabilidade por meio da multiplicação de quatro parâmetros geológicos e hidrológicos, os quais são: grau de confinamento hidráulico, ocorrência do substrato subjacente, distância ao nível da água subterrânea e tipo de solo. Foram usadas ferramentas de um Sistema de Informações Geográficas - SIG. Os resultados mostram que a maior parte do território está em um nível de vulnerabilidade baixo com 39,75%, em nível médio com 24,26%, seguido de um nível de vulnerabilidade extrema com 14,7%, 10,68% com nível alto e 10,61% insignificante. A pesquisa contribuiu para evidenciar como as características intrínsecas do aquífero Dunas-Barreiras da Região Metropolitana de Natal, permitem o transporte de poluentes até o lençol freático em algumas áreas como na zona costeira e nas porções mais baixas das bacias hidrográficas.
Predicting of psychological well-being with adoloscents according to personality traits and life goals
Authors: Çelik Seda , Cihangir Çankaya Zeynep
Published: June 2022

This study was conducted in order to determine the predictive power of relationships with personality traits and life goals in psychological well-being of adolescents. Psychological Well-being Scale, Life Goals Scale, Adjective Based Personality Scale and Personal İnformation Form were used in the study to collect the data.  In the first part of the research, The validity and realibity studies of Psychological Well-being Scale, Life Goals Scale, Adjective Based Personality Scale was conducted with 635 adoloscents. The second part of the research data were collected from 933 adolescents to determine predictive power of relationships with intrinsic-extrinsic life goals, openness to experience, conscientious, extroversion, aggreableness, neuroticisim on the psychological well-being of adolescents. Stepwise multiple regression analysis was used in the process of data analysis. The results of the analysis showed that intrinsic-extrinsic life goals, openness to experience, conscientious, extroversion, aggreableness, neuroticisim scores significantly predicted the psychological well-being of adolescents and explained 47.6 % of change in their psychological well-being. These findings were discussed in the light of the relevant literature and developmental features of adolescents.
​Extended English summary is in the end of Full Text PDF (TURKISH) file.
 
Özet
Bu araştırma ergenlerin psikolojik iyi oluş düzeylerinin, kişilik özellikleri ve yaşam amaçları değişkenleri açısından yordanma gücünün belirlenmesi amacı ile gerçekleştirilmiştir. Araştırmada veri toplama aracı olarak Psikolojik İyi Olma Ölçekleri, Yaşam Amaçları Ölçeği, Sıfatlara Dayalı Kişilik Testi, Kişisel Bilgi Formu kullanılmıştır. Araştırmanın birinci kısmında Psikolojik İyi Olma Ölçekleri, Yaşam Amaçları ve Sıfatlara Dayalı Kişilik Testi’nin geçerlik ve güvenirlik çalışmaları 635 ergen ile gerçekleştirilmiştir. Araştırmanın ikinci kısmında ergenlerin psikolojik iyi oluş düzeylerinin, içsel ve dışsal yaşam amaçları, dışa dönüklük, nevrotizm, sorumluluk, deneyime açıklık, yumuşak başlılık, duygusal dengesizlik, değişkenleri açısından yordanma gücünün belirlenmesi amacıyla 933 ergenden veri toplanmıştır. Verilerin analizinde aşamalı çoklu regresyon analizi kullanılmıştır. Yapılan analiz sonrasında içsel ve dışsal yaşam amaçları, dışa dönüklük, nevrotizm, sorumluluk, deneyime açıklık, yumuşak başlılık, duygusal dengesizlik değişkenlerinin ergenlerin psikolojik iyi oluş düzeylerini anlamlı bir biçimde  yordadığı ve birlikte ergenlerin psikolojik iyi oluşundaki değişimin % 47.6’sını açıkladığı bulunmuştur. Araştırma bulguları, ilgili araştırmalar ve ergenlerin gelişimsel özellikleri çerçevesinde tartışılmıştır.
Das Verhältnis zwischen Hieroglyphen- und Keilschrift-Luwisch
Authors: Breyer Francis
Published: June 2022

The linguistic differences between Hieroglyphic and Cuneiform Luwian have long been known. However, it is unclear how these should be assessed: How exactly do the two varieties relate to each other? Are they different dialects, just different registers or even different sociolects? Based on the thesis developed recently, according to which the transformation of the Luwian hieroglyphs into a veritable writing system only took place in the context of the late Hittite empire, this article works out that Hieroglyphic Luwian probably is to be considered a functiolect.
Two Hurro-Urartian Lexical Parallels
Authors: Grekyan Yervand
Published: June 2022

Related words in the Hurrian and Urartian vocabularies are numerous due to the affinity of these two languages. To the list of common roots and terms we can now add two more examples:iradini“bird” andpurulini“divination(?)”.
Eine neubabylonische Edition eines mittelbabylonischen Nergal-Balaĝs (BM.35434)
Authors: Heinrich Adrian C.
Published: June 2022

Published here for the first time, the Neo-Babylonian tablet BM.35434 sheds new light on the transmission history of the Sumero-Akkadian balaĝ-prayer a-gal-gal buru₁₄ su-su || butuqtu muṭebbât ebūri “Flood that drowns the harvest” dedicated to Nergal, the god of pestilence and war. Due to its exceptional colophon, BM.35434 makes for an interesting case study in first-millennium scribal practices in the context of ritual lamenting and Emesal prayers: special points of interest are the use of older sign forms, the scribe and the family he comes from, the designation of the tablet as a copy of an “old large tablet” (dub.gal libir.ra), and the insertion of paratextual glosses that describe the state of preservation of the copied exemplar. An appendix contains copies and transliterations of hitherto unpublished fragments and joins that pertain to a-gal-gal buru₁₄ su-su.
On the Identity of Hartapu
Authors: Massa Michele , Osborne James F.
Published: June 2022

The recent discovery of the Hieroglyphic Luwian inscription of TÜRKMEN-KARAHÖYÜK 1 in the Konya Plain (Turkey) has sparked a debate regarding its author, Great King Hartapu, the dates of his rule, and his role in the political geography of south-central Anatolia. Several authors now propose that two kings of the same name may have reigned at different times in the same region. This paper proposes a textual analysis of all the Hartapu inscriptions, together with an assessment of the archaeological and historical contexts in which they were found. In light of this, we argue that only one individual called Hartapu was responsible for the whole corpus and that he reigned during the Middle Iron Age, likely in the 8thcentury BCE.
The Cult of Ištanuwa (and Lallubiya) between Hattian and Aegean Cultures
Authors: Hutter-Braunsar Sylvia
Published: June 2022

This article collects information about the peculiar features occurring in the Ištanuwa/Lallubiya-texts which can be connected with their counterparts from the other cultic layers of the Hittite realm – namely the Hattian cults from the Hittite core land –, Mesopotamia, the Aegean, and classical sources, respectively. The sum of gathered data represents a better starting point for studying cultural commonalities, connections and transfers between these areas than the already presented isolated remarks, scattered in secondary literature. Especially the comparing features from the Ištanuwa/Lallubiya Luwian layer and the Hattian-Hittite layer will be treated here.
Religious Discourse in Ancient Mesopotamia
Authors: Masetti-Rouault Maria Grazia
Published: June 2022

The modern representation of cuneiform literature as a creation depending on a religious discourse leads us to think that myths and rites have structured not only the institution of kingship, but also all Mesopotamian knowledge, as well as social life. If political ideology needed a religious support to explain the king’s authority and privileges, later textual traditions show that the same intellectuals working for the royal court and urban elites developed at the same time, beyond religion, an alternative conception of their own power as knowledge and control of history, through narration, and nature through “magic”, in order to change reality and the gods’ will.
Preparation of polyamide 12 powder for additive manufacturing applications via thermally induced phase separation
Authors: Su Dandan , Yang Jingkui , Liu Shan , Ren Lulu , Qin Shuhao
Published: June 2022

Spherical polyamide 12 (PA12) powder for selective laser sintering (SLS) was prepared by thermally induced phase separation (TIPS) method. It was authenticated that the mixed solvent can regulate the liquid–liquid phase separation (LLPS) process by changing the ratio of diluent to non-diluent. The polymer droplets mainly coalesced in the solution, and then the crystal nucleus of PA12 was formed in the droplets. Finally, high crystallinity PA12 powder was precipitated. The morphology, particle size distribution, thermal properties, the change of crystal structure, and powder spreading performances of the obtained powder were characterized. The powder had a narrow particle size distribution, an average particle size of 55.2 μm, and a broad sintering window of 29°C. The results exhibited that the powders prepared by TIPS had excellent sintering properties, and TIPS method provided more choices for SLS technology.
Writing “Home” in a Pandemic: The Prevalence of Gendered Topics in Congressional COVID-19 Communications
Authors: Marin Hellwege Julia , Cormack Lindsey
Published: June 2022

The COVID-19 pandemic had a disparate impact across populations leaving questions about gendered representation in Congress. We ask whether women and men in Congress wrote “home” about COVID-19 at the same rates and if their attention on gendered topics such as childcare, schooling, and care-taking differed even when the issue space was significantly narrowed. We argue members of Congress use gendered and partisan lenses to frame their positions around the pandemic. We find both parties send a similar number of COVID-19 related messages and that women compared to men – within each party – focus on areas traditionally associated with women’s care-taking duties.
Hybrid 18F-florbetapir PET/MRI for assessing myelin recovery in GFAP-A patients
Authors: Meng Huanyu , Zheng Shuyu , Yuan Shaicun , Zhou Qinming , Gao Yining , Ni You , He Lu , Yin Dou , Zhang Min , Chen Sheng
Published: June 2022

Glial fibrillary acidic protein astrocytopathy (GFAP-A) is a rare autoimmune disease of the central nervous system that was newly reported in 2016. Previous studies have speculated that the pathological mechanism and clinical outcome of GFAP-A lie in the demyelination of the central nervous system, but due to the limitations of MR, this conclusion has not been further confirmed from the perspective of neuroimaging. A non-invasive, quantitative measurement of demyelination would be clinically valuable, given its critical role in mediating GFAP-A. Here, we report a case in which we use 18F-florbetapir positron emission tomography-magnetic resonance imaging (PET/MRI) to evaluate myelin recovery with follow-up in the patient with GFAP-A. Our patient displayed a decreased uptake of PET tracer 18F-florbetapir in the brain lesions and lower distribution volume ratio in the damaged white matter lesions compared to the normal-appearing white matter, indicating significant intracranial demyelination. After treatment, the 18F-florbetapir PET/MRI examination showed a significant increase in the uptake of 18F-florbetapir in the brain lesions, along with a reduced Expanded Disability Status Scale score. Although only a small number of patients have been validated, this case first reported 18F-florbetapir PET/MRI could quantitatively and non-invasively assess the myelin recovery in GFAP-A patients, which may lead to improvements in the early diagnosis and long-term prognosis.
Neuro Narratives
Authors: Naegeli Costa Christina
Published: June 2022

The current research uses autoethnography as a method to share my experience as a brain tumor patient. In this essay, I reference poems from the day of my diagnosis through my surgery, recovery, and following treatment to demonstrate the thematic factors that allowed me to cope and experience positive emotions as an oncology patient. Results included the factors of trust in medical care, utilizing social support, finding meaning and purpose, and self-love and gratitude. I discuss the implications of these factors in relation to resilience structures and discourses to better serve other oncology and chronic illness patients.
Cultural Diplomacy for Colombia: An opportunity to Be Taken
Authors: Montoya Ruiz Sandra
Published: June 2022

This paper elaborates on the results of qualitative research on the role of cultural diplomacy in Colombian foreign policy between 1991 and 2014 and its links with the current scenario. Based on a comparative analysis of various experiences on cultural diplomacy from five States, and taking Wendt’s constructivism in dialogue with Nyes’ soft power, the paper elaborates on the current challenges of Colombian cultural diplomacy. This paper argues, that despite the minor and discontinuous role of this diplomacy in the Colombian Foreign Policy, there is an opportunity to be taken for re-framing the role of the Colombian State in the construction of a postconflict scenario and the achievement of a renewed Colombian performance in the international system.
Impacto de la deuda pública colombiana en las comunidades rurales
Authors: Nieto-Gómez Libia Esperanza , Cabrera-Otálora Martha Isabel , Giraldo-Díaz Reinaldo
Published: June 2022

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Incorporación de los Key Audit Matters en las actividades de auditoría: una revisión documental
Authors: Contreras Cano Geraldine Stephania
Published: June 2022

Para el desarrollo del presente trabajo, se realizó una revisión documental que serviría como insumo para analizar la necesidad que surge por parte del IAASB para implementar la International Standard on Auditing (ISA) 701, relacionada con las cuestiones clave de auditoría (KAM, por sus siglas en inglés) y presentar el estado del arte de las investigaciones que se han realizado respecto a los efectos de los KAM en los informes de auditoría. A la vez, se busca presentar cómo ha avanzado la normativa colombiana respecto a la implementación de la ISA 701, que trata este tema.

Entre los principales resultados de esta investigación, se resalta que los efectos de los KAM pueden variar entre países e incluso entre industrias, lo que genera que los resultados de los estudios analizados no sean homogéneos. No obstante, se deduce que los KAM pueden traer valor informativo a nivel generalizado para los usuarios de la información, debido a que todos los auditores de compañías listadas, sin importar su ámbito de trabajo, deben presentar las cuestiones que a su juicio profesional requirieron mayor atención en la labor realizada.
El individuo como lugar de revelación. Líneas de diálogo entre la teología del monacato cristiano antiguo y el mundo contemporáneo
Authors: Rada Pardo Juan Camilo
Published: June 2022

En la búsqueda de una posibilidad de espiritualidad en el mundo contemporáneo, se descubre la relación que existe entre la concepción actual de individuo con la antropología de base del monacato cristiano antiguo. Por esta razón, se propone un acercamiento a las capacidades personales del monje y se relacionan con las cualidades del individuo contemporáneo. Este vínculo desemboca en una posibilidad de espiritualidad fundamentada en las capacidades personales del sujeto en búsqueda de un significado espiritual para el ser humano en términos de bienestar integral y plenitud de vida.
La teología islámica de la liberación desde shadaab rahemtulla frente la tradición islámica
Authors: Hio Rojas Diego Alejandro
Published: June 2022

El presente artículo analiza a la teología islámica de la liberación frente al tradicionalismo islámico a partir de las diversas reflexiones del académico indio Shadaab Rahemtulla. La tesis principal de Rahemtulla radica en postular a la lectura de los suras coránicos como una acción liberadora, esto es, sin rígidas ataduras políticas o sociales, lo anterior se presenta como el medio sine qua non para alcanzar una verdadera emancipación social de todas aquellas condicionantes que han imposibilitado a muchos países islámicos tener procesos duraderos y significativos tendientes a mejorar los índices de equidad social, participación política y libertad de expresión. Por lo anterior, no solo se analizan los métodos de interpretación del texto sagrado, sino las prácticas hegemónicas que el discurso tradicional ha implementado a lo largo del tiempo en aras de conservar el status quo.
Acercamiento al Pacto Educativo Global
Authors: Niño Súa Francisco
Published: June 2022

Hablar del Pacto Educativo Global implica profundizar en el pensamiento del Papa Francisco, en la génesis y en las consecuencias de una propuesta verdaderamente revolucionaria. Por eso voy a realizar mi presentación en un pequeño “Decálogo” de tres secciones, cada una de ellas tripartita, que he denominado “Texto”, “Contexto” y “Postexto” (este último como una especie de neologismo que proyecta el texto y su contexto hacia el futuro). En la última parte, la conclusión, me referiré a sus implicaciones para el quehacer teológico. Siguiendo el método escolástico comenzaré esta primera parte con una necesaria clarificación de términos.
Pastoral urbana. Un reto para la iglesia hoy
Authors: Zúñiga Rodríguez Wilfrido
Published: June 2022

La pastoral urbana es una propuesta para los tiempos modernos que exigen reinterpretaciones de las distintas esferas donde haya vida.  Creyentes o ateos, están invitados a comprender la existencia en función de la condición religiosa, si entendemos este principio (condición religiosa) como la posibilidad de concebir que la vida es sagrada, que es un regalo, que invita a compartirlo, como un imperativo existencial en el mundo. Este preámbulo nos estimula a proponer en este texto como objetivo: mostrar sin pontificar algunos requerimientos que se le pueden exigir a esta nueva propuesta de la misión de la iglesia hoy donde se busca que, la praxis, es decir, la acción, se comprenda como la forma de vivir y la forma de habitar un mundo bajo los parámetros de la imagen de un Dios perdón (pastoral) en miras de articular: evangelizador y evangelizado, mensaje y mensajero, teoría y praxis, vida humana y experiencia de Dios, en la búsqueda de volver a dar sentido al mensaje integrador de la buena nueva de Jesús de Nazaret en una época cuya principal característica es la fragmentación no sólo social sino también individual.
Cristo de las Américas. El diálogo entre Thomas Merton y Pablo Antonio Cuadra en sus cartas
Authors: Argüello Lacayo José
Published: June 2022

En abril de 1958 el poeta nicaragüense Pablo Antonio Cuadra (1912-2002) conoció personalmente al monje y poeta norteamericano Thomas Merton (1915-1968) durante una visita a su primo hermano Ernesto Cardenal, entonces novicio de Merton en el monasterio trapense de Getsemaní, en Kentucky, Estados Unidos. Entre ambos escritores se desarrollaría una esporádica y fecunda correspondencia hasta la inesperada y súbita muerte de Merton en Bangkok en 1968, en la que intercambiarán proyectos literarios, confidencias e intuiciones artísticas y espirituales. Inédita hasta el presente, tal correspondencia permite asomarnos a su intimidad y valorar las aspiraciones entrelazadas de ambos poetas y autores cristianos. El presente artículo recoge lo esencial del diálogo epistolar entre Thomas Merton y Pablo Antonio Cuadra.
Los proyectos ambientales escolares: una alternativa para la investigación participativa en la Institución Educativa Patio Bonito (Marquetalia-Caldas, Colombia)
Authors: Murillo Montoya Sergio Adrián
Published: June 2022

En Colombia, los proyectos ambientales escolares-PRAE fueron incluidos en la dimensión ambiental con el decreto 1743 de 1994. Sin embargo, se ha observado que, en muchos colegios del país, estos proyectos son recientes, no están bien elaborados y responden más a una obligación por cumplir. El objetivo del presente trabajo fue revisar y reestructurar el PRAE de la Institución Educativa Patio Bonito de Marquetalia Caldas, teniendo presente los 6 ejes del PRAE que propone el Plan Nacional de Educación Ambiental y algunos objetivos del desarrollo sostenible.  Se empleó una metodología mixta que comprende encuestas e investigación participativa. El nuevo PRAE se aborda desde un concepto holístico, sistémico e interdisciplinar, promoviendo la investigación participativa, y permitido la conformación de tres grupos de investigación y la elaboración de un subproyecto articulado con el SENA.
LA La lúdica para el aprendizaje significativo de la fotosíntesis en las microalgas y su aporte en la disminución de la huella de carbono
Authors: González Ardila Marielis
Published: June 2022

La lúdica en la educación permite formar estudiantes críticos, con habilidades y destrezas en cualquier campo de acción.  Este Artículo tiene como objetivo desarrollar una estrategia lúdica didáctica para promover el aprendizaje significativo de la fotosíntesis en las microalgas y su aporte en la reducción de la huella del carbono a partir de un juego interactivo utilizando la plataforma de Quizizz. El desarrollo de la estrategia didáctica comprendió; Una fase diagnostica de conocimientos previos, diseño de una propuesta estructurada que incluyo el uso de las TIC y  valoración de los resultados a través de la prueba  Alfa de Cron Bach y la prueba de Mann-Whitney para determinar la confiabilidad del Pretest y el Postest; Así mismo, esta investigación se enmarca en un paradigma interpretativo con un enfoque cualitativo con el fin de comprender el porqué de una realidad.

PALABRAS CLAVES: Lúdica, Huella de Carbono, Microalgas, Fotosíntesis.
Contribuciones de la metodología Lesson Study en las evoluciones de las prácticas de enseñanza en docentes de primaria
Authors: Cifuentes Garzón José Eduardo , Rojas Jiménez Waldo Alexander , Ruiz Céspedes Liliana Andrea , Vergara Núñez Yuly Carolina
Published: June 2022

El presente artículo expone los resultados de una investigación desarrollada por tres profesores de primaria de colegios públicos de Bogotá-Colombia. El objetivo del estudio fue analizar la transformación de las prácticas de enseñanza a partir de la implementación de la metodología Lesson Study. Se adoptó el diseño de la Investigación Acción Pedagógica, bajo un enfoque cualitativo, con el empleo de la metodología de la Lesson Study y el análisis de ciclos de reflexión. Como resultados, se presentan las evoluciones en las acciones de planeación, implementación y evaluación del aprendizaje ocurridas durante el proceso investigativo. Se concluye que, con la Lesson Study se promueve el trabajo colaborativo, la reflexión y el mejoramiento de las prácticas de enseñanza en los diferentes niveles educativos.
Audiencias educativas
Authors: Caballero Ardila Eduardo Antonio
Published: June 2022

Este trabajo analiza desde la educomunicación, seis cambios conductuales de la población joven, que mediatizados por la interacción digital y el consumo audiovisual, tienen impacto en sus hábitos de estudio, y consecuentemente en sus resultados académicos en la educación virtual.

Es un trabajo interdisciplinario, entre las ciencias de la educación y de la comunicación, que desde la óptica del comportamiento de las audiencias en los medios de comunicación y en las redes sociales, busca desarrollar competencias de afabetización mediática en los docentes como una manera para conectar efectivamente con las audiencias educativas, y motivar el éxito de los objetivos académicos.
Autopercepción del orientador educativo venezolano en la gestión de procesos vocacionales y del aprendizaje
Authors: Briceño Nuñez Chess Emmanuel
Published: June 2022

La presente obra muestra resultados asociados a la autopercepción del orientador educativo venezolano en la gestión de procesos vocacionales y del aprendizaje. La investigación tuvo un diseño transaccional y de campo siguiendo una investigación de tipo descriptiva. La población estuvo compuesta por los orientadores educativos residentes y en ejercicio de la República de Venezuela, adscritos al Ministerio del Poder Popular para la Educación y/o a la Asociación Venezolana de Orientadores en cualquiera de los distintos capítulos que la conforman. La muestra se limitó a 200 sujetos participantes. Los datos obtenidos se procesaron con el Paquete Estadístico para las ciencias sociales SPSS (Statistical Package for the Social Sciences) que emplea procesos estadísticos y matemáticos. La información se organizó en tablas simples, y se representó visualmente por medio de gráficos circulares y de barras, según su utilidad. Los resultados evidencian que el orientador educativo venezolano se autopercibe como un agente activo capaz de atender una serie de aspectos y situaciones enmarcados en la gestión de los procesos vocacionales y del aprendizaje.
El ensamble musical: estrategia metodológica para la inclusión de una población neurológicamente diversa
Authors: R Pérez Luis , Jaimes Sonia
Published: June 2022

El ensamble musical es una estrategia metodológica que genera un ambiente inclusivo y colaborativo dentro de una institución. Resultado de una investigación cualitativa, el artículo tiene por objetivo analizar los retos investigativos que generaron las acciones en investigación-acción con seis estudiantes diagnosticados con discapacidad y pertenecientes al programa de música inclusiva de la Escuela Municipal de Artes y oficios de Bucaramanga (EMA), con quienes  se logró intervenir sus prácticas y limitaciones por medio de un ensamble musical, con el cual se impactó el proceso inclusivo de los estudiantes y sus familias. Las conclusiones reiteran que la investigación de las habilidades de los participantes y la implementación de la secuencia didáctica diseñada, los estudiantes pudieron desarrollar las habilidades necesarias para asumir el montaje de dos arreglos musicales trabajados en esta propuesta y hacer parte de un ensamble musical inclusivo, el cual fue integrado a los resultados anuales de la EMA.
Changing trends in the epidemiology of gastric cancer
Authors: Grad Cosmin , Grad Simona , Fărcaș Radu A. , Popa Stefan , Dumitrașcu Dan L
Published: June 2022

Currently being the seventh most prevalent form of cancer worldwide, and the fifth most common cause of cancer-related death, based on GLOBOCAN 2020 data, gastric cancer is still an important public health problem, despite its dropping incidence. Regions around the world are still at high-risk, mostly in populations with a high prevalence of Helicobacter pylori infection or a carcinogenic favorable diet. Gastric cardia cancer incidence is on the rise in some areas. Great steps were made in the last decades in understanding the pathogenesis of gastric cancer and its risk factors. Host genetic polymorphisms play a quintessential role in disease outcome. Helicobacter pylori eradication and endoscopic surveillance are the most effective options to further decrease gastric cancer incidence. Surgery is required for a curative treatment in most cases.

            This review summarizes the latest worldwide epidemiological data of gastric cancer and aims to provide an accessible and credible source of evidence for physicians who assess risk factors for gastric cancer.
THE PHENOMENOLOGICAL APPROACH IN THE ANALYSIS OF THE POETICS OF FOLKLORE
Authors: Vlasov Andrey
Published: June 2022

The article attempts to substantiate the phenomenological approach to the study of traditional culture. The principles of phenomenological analysis consist in expanding the boundaries of perception and understanding of folk culture facts, which include, among other things, musical, choreographic, applied arts, or, more broadly — everything that is understood by craft (“doing”) in the Aristotelian sense. The key to this methodological approach is the figure of an artisan, his natural sense of beauty and taste in the choice of certain style trends of an era. The concept of self-reflection of the bearers of traditional culture becomes the backbone in the context of interdisciplinary folklore studies. The activity of the local community members in studying the culture of their region is directly related to the comprehension and interpretation of tradition. The purpose of the phenomenological approach is to restore the value orientations of cultural activity and ideas about the natural aesthetic taste in all types and forms of folk art. The key role in the proposed approach is played by the concepts of skill and craft, which are traditionally close to the perception of objects of the so-called applied arts, choreography and music.
A WORD FROM THE EDITORS
Authors: Andrianova Irina , Vyal Elena , Zavarkina Marina , Alekseeva Lyubov
Published: June 2022

The articles included in the second issue of "The Problems of Historical Poetics" for 2022 are dedicated to the 60th anniversary of the deputy editor-in-chief of the journal, one of the leading experts on ancient Russian literature Alexander Pigin. These articles were written by his colleagues and students from different cities of Russia and are related to his scientific interests and activities.