bluuebunny/crossref_metadata_2025 huggingface dataset:
A Novel Variant in Iranian Patient with Cystinuria: A Case Report
Authors: Mardi Ali , Heidary Hamed , Mousavi Seyyed Mohammad , Khazaei Ghasem , Taghizadeh Eskandar
Published: September 2021

Cystinuria is an autosomal recessive disorder in which the renal reabsorption of cystine, arginine, lysine and ornithine are disturbed. The two genes, the pathogenic forms of which are responsible for the disorder, are SLC7A9 and SLC3A1. In this study, we describe a disease that has a new c.916A> T variant (p. K306 *) in exon 5 of the SLC3A1 gene. This variant results in the NMD phenomenon in which the protein product is not produced because of mRNA destruction. In 2020, blood sample of a 41-yr-old man from east Azerbaijan, Iran together with his parents were collected to be studied. PCR and direct sequencing were performed to detect the possible SLC3A1 variant. Whole-gene sequence analysis done by Mutation surveyor Software revealed a novel nonsense homozygous variant in exon 5 of the gene. Parental Sequence Analysis shows that they are heterozygous. According to ACMG guideline, this variant is considered as pathogen. Finding serious mutations can allow rapid screening for cystinuria by analyzing common mutations. It should also be considered as a pathogenic variant in patients’ cystinuria.
Obesity and Its Relation to Eating Habits among Rural-to-Urban Migrant Children in Shanghai, China
Authors: Yao Liying , Zhang Yiqiong , Li Yuqiang , Lu Jinkui , Kuan Garry
Published: September 2021

The article's abstract is not available.
Effects of Plyometric Training on Electromechanical Delay of College Women
Authors: Kim Me-Suk , Lee Sang-Ho , Kim Tae-Young
Published: September 2021

The article's abstract is not available.
Prevalence of Overweight and Obesity among Students of Uni-versity in Pristina/Kosovska Mitrovica, According to Different Anthropometric Indices
Authors: Mitic Nebojsa , Popovic Ljiljana , Milic Marija , Radic Ivan , Popovic Brankica
Published: September 2021

The article's abstract is not available.
Evaluation and Comparison of Clinical Rounds from the Perspective of Professors and Students of Shahrekord University of Medical Sciences
Authors: Malekpour-Tehrani A , Moezzi M , Hosseini SS , Hosseini SM
Published: September 2021

Introduction: Evaluating different fields of clinical education is necessary to improve the medical course. Among these, clinical rounds are an important part of clinical education. Therefore, achieving maximum realization in any clinical field is the goal of every medical training center.
Methods: Present descriptive cross-sectional study was conducted at Shahrekord University of Medical Sciences by census method on more than 67% of clinical medical professors and 79% of medical students who are on internship. The research instrument included a questionnaire of demographic information and a clinical round, which was prepared based on clinical standards approved by the Ministry of Health. 30 out of 44 clinical professors and 30 out of 38 interns succeeded in completing the questionnaires. The obtained data were analyzed by SPSS-16 software and tests (T-test and ANOVA).
Result: The mean scores of clinical rounds of professors were 65± 13.16 and interns were 52.47± 35.19 and in general, the situation in this field was described as higher than the average (42) for both groups. Comparison of the two groups also showed a significant difference (P = 0.00). Thus, the mean scores of clinical round scores in the professors’ group were higher than the average scores of the interns’ group.
Conclusion: The current clinical rounds situation in Shahrkord University of Medical Sciences was described as more favorable than average. Therefore, in order to further promote medical education, it is recommended that universities continuously evaluate and monitor the status of various areas of clinical education in order to reach the ideal level as soon as possible.
Energy-saving technology for betulin extraction from birch bark waste
Authors:   Kazan National Research Technological University («KNRTU»), Safina A.V. , Abdullina D.R. ,   Kazan National Research Technological University («KNRTU»), Safin R.G. ,   Kazan National Research Technological University («KNRTU»), Arslanova G.R. ,   Kazan National Research Technological University («KNRTU»), Valeev K. V. ,   Kazan National Research Technological University («KNRTU»)
Published: September 2021

The paper presents experimental studies on the extraction of betulin from birch bark by one-stage extraction method in a flask with a reflux condenser and extraction in a Soxhlet apparatus. It is found that the highest betulin yield (up to 40 %) is achieved by extraction in a Soxhlet apparatus with periodic renewal of the extractant. The kinetic dependences obtained in the course of the research allows constructing an equilibrium dependence necessary to determine the rational number of phase contact stages when designing an industrial continuous extraction plant. On the basis of the studies carried out, a scheme of energy and resource-saving technology for extracting betulin from birch wood waste is proposed and a pilot plant is developed, which can be used to work out the modes of obtaining high-purity betulin. The absence of losses of organic extractants and the reuse of Florentine water determines the ecological purity of production. Refined birch bark can be used for the production of wood-polymer composite materials or as a fuel for generating thermal energy, which reflects the energy and resource-saving potential of this technology.
Ethics and Cyber Libraries: Challenges Facing the Values and Ethics in LIS
Authors: Omer Jessica
Published: September 2021

Cyber libraries face many challenges when it comes to access. These challenges can lead to cyber libraries failing in following the guidelines for the values and ethics of the LIS professional. Some authors have argued that cyber libraries are the future of libraries. They argue that patrons want information immediately at their fingertips. The fact that library budgets are shrinking and electronic sources can be cheaper cause many libraries to lean more towards the idea of cyber libraries. However, while digital libraries do have their advantages, they are not perfect. We live in a time where librarians have their feet in two worlds; a world of technology and a world of paper.
Management of diversity in Peruvian companies: The cases of IBM, Atento and Scotiabank
Authors: Gastelú Ledesma Isabel , Martinez-Hague Paloma
Published: September 2021

The management of diversity is important today, as proven by the varied research available on this topic. However, when we wanted to understand the management of LGBT diversity, we found little research worldwide, let alone in Latin America.We found a measurement model in the region developed by the Ethos Institute of Brazil which allowed us to understand the current situation of LGBT diversitymanagement in three companies in Peru. Since Peru and Brazil are both Latin American countries, one could think that the model is international and transversal to both realities. However, our research proposed an adaptation of the model to simplify it because elements found in Brazil were not yet present in Peruvian companies. This qualitative investigation applies the adapted and contextualized instrument to three large companies in Peru and presents a rather unique and interesting view of LGBT diversity management.
Caracterización de la gestión de la operación del Centro MAC Ventanilla a partir del Modelo EFQM
Authors: Moreno Herrera Allison Andrea , Avilés Elías Gabriel Marcial
Published: September 2021

En Perú, en el marco de la Política Nacional de Modernización de la Gestión Pública, se viene trabajando por un Estado orientado a los ciudadanos y conentidades públicas que funcionen articuladamente. Por ello, se crea la Plataforma de Mejor Atención al Ciudadano (Plataforma MAC) para mejorar la calidad de los servicios del Estado, articulándolos y acercándolos a los ciudadanos mediante diversos canales de atención. En 2014, el Centro MAC Ventanilla (CMV) inicia su funcionamiento gestionado por la Municipalidad Distrital de Ventanilla, logrando congregar 11 entidades públicas y realizar 522 488 atenciones durante el año 2018.El presente artículo describe y analiza la gestión de la operación del CMV mediante los agentes facilitadores del Modelo EFQM de Excelencia. Si bien el CMV puede constituirse como uno de los principales canales presenciales debido a su alto número de atenciones, aún queda pendiente identificar oportunidades de mejora, establecer prioridades e innovar.
Painting education of Kazakh mythology
Authors: Karim Baigutov , Seksembaevich Myrzakanov Madvakas , Suyuberdieva Aiman , Maulenberdieva Gulzhan , Kudaibergenova Marzhan , Baybolat Lyazzat , Ibrayeva Kymbat
Published: September 2021

Various scientific studies, interpretations, analyses, and comparisons have revealed a strong link in the origin of Kazakh mythology in contemporary Kazakh society. The main problem in this lies in the fact that existing research on mythology has always centered in fields of literature, philosophy, religion and culture, and history.  Previous scholars have always overlooked the study of mythology in the field of art. It’s for this reason, that this research article centered on the mythology in the art of painting education and especially pictorial analysis of Kazakh mythology. In the article, the definition and history of Kazakh mythology are given and the studies of the researchers on mythology are mentioned. The painting educations made within the scope of the research article are inspired by the myth of "Er Tostik". The research conducted within the scope of a creative and scientific analysis shows that the works related to the formation of Kazakh mythology have an important place in the history of Kazakh painting education. Besides, important subjects of Kazakh mythology in Kazakh art history were determined and how they affected the works of the painters were examined and interpreted comparatively.

 

Keywords: Kazakh mythology, Kazakh painters, Er Tostik, art, painting, woodcut technique
Xylaria sp.; The Candle Snuff Fungus from West Java
Authors: Hermawan Rudy , Khairillah Yuyun Nisaul
Published: September 2021

Candle snuff fungus belongs to Xylaria group. Generally, Xylaria has a form like stick or candle or elongated fruit of shapes. Xylaria is classified into Ascomycota within Xylariaceae. This study found one species of candle-shaped mushroom in IPB Unversity. This study aimed to identified and characterized the specimen using molecular and morphological data. The specimen was collected and preservedinto FAA solution and deposited into Herbarium Bogoriense as BO 24426. Molecular analyses using Large Subunit as a region for amplification showed that the BO 24426 was classified into Xylaria sp. This species closes to Xylaria consociata. The stromata were erected, unbranched, and tapered to the apex. The texture was rigid and hard. Ascus bore 8 ascospores. The ascospores were fusiform or bean-shaped and smooth. The morphological observations supported molecular identification of BO 24426 as Xylaria sp. Other genes were needed to ensure the exact species of Xylaria
Association Between Cigarette Smoking And Cognitive Function In Stroke Patients Of Siloam Lippo Karawaci Hospital
Authors: Raspati Raissa Putri , Gunawan Pricilla Yani
Published: September 2021

Stroke is cerebrovascular disease, causing deterioration of brain function as a result of cerebral blood flow disruption. Stroke is the third leading cause of death in the world and is considered an important cause of long-term disability and cognitive impairment. Risk factors of stroke are further divided into unmodifiable risk factors and modifiable risk factors, with one of the most common modifiable risk factors of stroke, is cigarette smoking. Besides being one of the risk factors that cause stroke, cigarette smoking is believed to have a role in cognitive impairment. This study aims to obtain information regarding the association between cigarette smoking and cognitive function in stroke patients of Siloam Lippo Karawaci Hospital. This research is an unpaired comparative analytical study with a cross-sectional design. Data sampling was taken by consecutive sampling on 56 stroke patients of Siloam Lippo Karawaci Hospital. Cognitive function was made based on the Montreal Cognitive Assessment version Indonesia (MoCA-INA). All data were analyzed by Chi-Square test using SPSS version 25 and the result is considered significant if the p-value < 0,05. From the result of this study. There is a significant association between cigarette smoking and cognitive function (p-value 0,004 and OR 5,343).
Functional Endoscopic Orbital Decompression Surgery in Acute Rhinosinusitis with Orbital Complication : A Case Report
Authors: Lekatompessy Michael , Kirana Amanda P
Published: September 2021

Introduction: Orbital complications secondary to acute rhinosinusitis can cause permanent vision loss and death if not treated promptly and appropriately. The prevalence of orbital complications due to rhinosinusitis is more common in children than adults, occurring in 3-4% of children with acute rhinosinusitis. Lamina papyracea in children has many dehiscences, the nasal cavity tends to be narrower and the mucosa is softer than in adults, therefore causing the spread of infection more easily from the sinuses to the eyes. Clinical presentation: a 4-year-old child presented with eye swelling and pus discharge in the right eye for 5 days before being admitted to the hospital, for which she was treated with medication and did not improve. On physical examination, there is a narrow nasal cavity, inferior turbinate edema, and hyperemia, mucopurulent discharge. CT scan and MRI revealed contrast enhancement in intraorbital with suspected intraorbital abscess with orbital cellulitis, right pansinusitis, and buccal abscess. Functional endoscopic orbital decompression was done immediately.

Conclusion: Orbital complications due to acute rhinosinusitis are uncommon but potentially lead to more fatal complications. Early diagnosis and aggressive treatment of immediate functional endoscopic sinus surgery and antimicrobial therapy have a good outcome.
Implementasi Metode Tabu Search Dalam Penjadwalan Menggunakan Analisa Pieces
Authors: Ariantini Made Suci , Dirgayusari Ayu Manik
Published: September 2021

Nowadays, Scheduling subjects is one of the first steps for starting the teaching and learning process in educational institutions. To do so, The role of teachers and school staff is very important and not easy because it takes a long time to compile it. SMK PGRI 4 Denpasar is one of the schools located in the city of Denpasar which is located on Jalan Kebo Iwa No 8, Padangsambian Kaja, Denpasar, Bali. It is a vocational high school that has a tourism expertise and computer engineering study program. Based on current results of observations and interviews, the process of making the subject schedules that run at SMK PGRI 4 Denpasar is still being done using Microsoft Excel, this has resulted in frequent errors in managing schedules such as conflicting schedule and it takes a long time to correct it. Tabu Search is an optimization method based on local search, where the search process moves from one solution to the next by selecting the best solution which is not classified as a prohibited solution. It is a combinatorial optimization problem-solving method that is incorporated into local search methods. This method aims to streamline the process of finding the best solution of a large-scale (np-hard) combinatorial optimization problem. Tabu search method to optimize the process of making the subject schedule and combined using PIECES analysis (Performance, Information, Economic, Control, Efficiency, Services). From this analysis, several problems will be obtained, which in the end can be identified clearly and more specifically, so that we can conclude some suggestions that will help in designing a new and better system. The Tabu Search method can be used to optimize the process of making the subject schedules at SMK PGRI 4 Denpasar, so that the scheduling process will be more easier than using Microsoft Excel.
Characteristics of Mesoscale Convective Complexes that Triggered Heavy Rainfall Related to Severe Flash Flood in Luwu, Sulawesi, Indonesia
Authors: Yulihastin Erma , Nuryanto Danang Eko , Trismidianto - , Muharsyah Robi
Published: September 2021

A severe flash flood hit Luwu, Sulawesi, Indonesia, on 13 July 2020. This flood was preceded by persistent heavy rainfall from 11 to 13 July 2020. In this study, we explore both the physical and dynamical processes that caused the heavy rainfall using a convection-permitting model with 1-km resolution. The heavy rainfall was modulated by the development of a pair of Mesoscale Convective Complexes (MCCs) during the night. The pair of MCCs was triggered by an anti-cyclonic vorticity anomaly over the Makassar Strait and was maintained by the warm front passing between the sea and land over central Sulawesi. This front was characterized by moist-warm and cold-dry low-level air, which may have helped to extend the lifetime of the MCCs. The northwestward propagation of the MCCs was due to the interaction between predominantly southeasterly monsoon and sea surface temperature anomalies.
The Effect of Night Low Temperature on Agronomical Traits of Thirty-Nine Pepper Accessions (Capsicum annuum L.)
Authors: Rajametov Sherzod , Lee Kwanuk , Jeong Hyo Bong , Cho Myeong Cheoul , Nam Chun-Woo , Yang Eun-Young
Published: September 2021

Pepper plants experience complex environmental factors including abiotic and biotic stresses in field and the importance of climate changes including low and high temperatures has been emerged. Low temperature stress in the growth and development is one of the most critical issues, which directly impact on the crop yield and productivity of pepper plants. It is essential to select and breed low temperature-(LT) tolerant pepper (Capsicum annuum L.) cultivars. The research was performed to assess the agronomical traits of 39 pepper accessions belonging to chili and bell fruit types which cultivated two different night temperature set-points at 15°C for suboptimal temperature (CT) and at 10°C for low temperature (LT), respectively. Plant heights (PH) of most pepper accessions in LT were significantly decreased compared to those in CT. The stem diameter (SD) and the length of main axis (LMA) were various depending on the genotypes under LT. Moreover, the number of flowers (NFL), the total number of fruits (NFR), fruit yield (FY), fruit fresh weight (FFW), fruit length (FL), fruit diameter (FD), and the number of seeds in a fruit (NSF) were notably declined in LT compared to CT. The evaluated agronomical traits between LT and CT were further applied for the correlation analysis, the principal component analysis (PCA), and the hierarchical cluster analysis. Notably, FY trait was correlated with other reproductive traits including NFR, FFW, FD, and FL on positive directions and LT treated-39 pepper accessions were clustered into seven groups by the clustering analysis. The selected accessions were primarily involved with the positive trends with the reproductive index including NFR, FL, FD, and FW traits and would be used for pepper breeding programs on developing LT-tolerant cultivars.
A Bridge Between the Breath and the Brain: Synchronization of Respiration, a Pupillometric Marker of the Locus Coeruleus, and an EEG Marker of Attentional Control State
Authors: Melnychuk Michael Christopher , Robertson Ian H. , Plini Emanuele R.G. , Dockree Paul M.
Published: September 2021

Yogic and meditative traditions have long held that the fluctuations of the breath and the mind are intimately related. While respiratory modulation of cortical activity and attentional switching are established, the extent to which electrophysiological markers of attention exhibit synchronization with respiration is unknown. To this end, we examined 1) frontal midline theta-beta ratio, an indicator of attentional control state known to correlate with mind wandering episodes and functional connectivity of the executive control network; 2) pupil diameter (PD), a known proxy measure of locus coeruleus (LC) noradrenergic activity; and 3) respiration for evidence of phase synchronization and information transfer (multivariate Granger causality) during quiet restful breathing. Our results indicate that both TBR and PD are simultaneously synchronized with the breath, suggesting an underlying oscillation of an attentionally relevant electrophysiological index that is phase-locked to the respiratory cycle which could have the potential to bias the attentional system into switching states. We highlight the LC’s pivotal role as a coupling mechanism between respiration and TBR, and elaborate on its dual functions as both a chemosensitive respiratory nucleus and a pacemaker of the attentional system. We further suggest that an appreciation of the dynamics of this weakly coupled oscillatory system could help deepen our understanding of the traditional claim of a relationship between breathing and attention.
Barriers and Challenges Going From Conventional to Cryogenic Superconducting Propulsion for Hybrid and All-Electric Aircrafts
Authors: Silva F. Ferreira da , Fernandes João F. P. , Branco P. J. da Costa
Published: September 2021

The development of electric aircrafts is becoming an important technology for achieving the goals set by the European Commission for the reduction of gases emissions by 2050 in the aeronautical transportation system. However, there is a gap between the values of specific power in commercial electric machines and the ones required for aeronautical applications. Therefore, the search for alternative materials and non-conventional designs is mandatory. One emergent solution is using superconducting machines and systems to overcome the current limits of conventional electrical machines. This work reviews the new hybrid and all-electric aircraft tendencies, complementing it with recent research on the design and development of high specific power superconducting machines. This includes the main topologies for hybrid and all-electric aircraft, with an overview of the ongoing worldwide projects of these types of aircrafts, systematizing the main characteristics of their propulsion systems. It also includes the research on superconducting machines for the purpose of high specific power, considering the impact on the redesign of aircraft systems in the electrical, cooling, and fuel source sense.
Neural Correlation of Faradarmani Consciousness Field Mind Mediation: A Comparative Functional Connectivity and Graph Analysis
Authors: Taheri Mohammad Ali , Modarresi-Asem Fatemeh , Nabavi Noushin , Maftoun Parisa , Semsarha Farid
Published: September 2021

The study of the brain networks using analysis of electroencephalography (EEG) data based on statistical dependencies (functional connectivity) and mathematical graph theory concepts is common in neuroscience and cognitive sciences for examinations of patient and healthy individuals. The Consciousness Fields according to Taheri theory and applications in the optimization of system under study have been investigated in various studies. In this study, we examine the results of working with Faradarmani Consciousness Field (FCF) in the brain of Faradarmangars. Faradarmangars are one of the necessary components in mind mediation of the function of Faradarmani Consciousness Fields according to Taheri. For this purpose, the functional and effective connectivity and the corresponding brain graphs of EEG from the brain of Faradarmangars is compared with that of non Faradarmangar groups during FCF connection. According to the results of the present study, the brain of the Faradarmangars shows significant decreased activity in delta (BA8), beta2 (BA4/6/8/9/10/11/32/44/47) and beta3 (in 34 of 52 BA) frequency bands mainly in frontal lobe and after that in parietal and temporal lobes in the comparison with the non Faradarmangars. Moreover, the functional and effective connectivity analysis in the frontal network shows dominant multiple decreased connectivity mainly in the case of beta3 frequency band in all parts of the frontal network. On the other hand, the graph theory analysis of the Faradarmangar brain shows an increase in the activity of the O2-T5-F4-F3-FP2-F8 areas and significant decrease in the characteristic path length and increases in global efficiency, clustering coefficient and transitivity. In conclusion, the unique higher graph function efficiency and the reduction in the brain activity and connectivity during the Faradarmani Consciousness Field mind mediation, shown the passive and detector like function of the human brain in this task.
Predictive Maintenance: An Autoencoder Anomaly-based Approach for a 3 DoF Delta Robot
Authors: Fathi Kiavash , van de Venn Hans Wernher , Honegger Marcel
Published: September 2021

Performing predictive maintenance (PdM) is challenging for many reasons. Dealing with large datasets which may not contain run-to-failure data (R2F) complicates PdM even more. When no R2F data are available, identifying condition indicators (CIs), estimating the health index (HI), and thereafter, calculating a degradation model for predicting the remaining useful lifetime (RUL) are merely impossible using supervised learning. In this paper, a 3 dof delta robot used for pick and place task is studied. In the proposed method, autoencoders (AEs) are used to predict when maintenance is required based on the signal sequence distribution and anomaly detection, which is vital when no R2F data is available. Due to the sequential nature of the data, non-linearity of the system, and correlations between parameter time series, convolutional layers are used for feature extraction. Thereafter, a sigmoid function is used to predict the probability of having an anomaly given CIs acquired from AEs. This function can be manually tuned given the sensitivity of the system or optimized by solving a minimax problem. Moreover, the proposed architecture can be used for fault localization for the specified system. Additionally, the proposed method is capable of calculating RUL using Gaussian process (GP), as a degradation model, given HI values as its input.
Keypoints to a Successful Newborn Hearing Screening. Thirty Years of Experience and Innovations
Authors: Sequi Canet Jose Miguel , Brines Solanes Juan
Published: September 2021

Congenital deafness is a major pediatric problem, affecting about 1.5-3 per 1000 newborns. The early treatment through cochlear implantation and auditory rehabilitation has been a historic milestone. Early diagnosis of congenital deafness is an essential requirement to obtain the best results, which is achieved through neonatal screening, a diagnostic practice that we began systematically at the Hospital Clínico in Valencia (Spain) 30 years ago.
Impact of the Pre-transplant Circulatory Supportive Strategy on Post-transplant Outcome: Double Bridge May Work
Authors: Chou Nai-Kuan , Chou Heng-Wen , Tsao Chuan-I , Wang Chih-Hsien , Huang Shu-Chien , Chen Kevin Po-Hsun , Chi Nai-Hsin , Yu Hsi-Yu , Chen Yih-Sharng
Published: September 2021

BACKGROUND: The number of waitlisted patients requiring mechanical circulatory support (MCS) as a bridge to heart transplantation is increasing. The data concerning the results of double-bridge strategy are limited. We sought to investigate the post-transplant outcomes across the different bridge strategies. METHODS: We retrospectively reviewed a heart transplantation database from Jan 2009 to Jan 2019. Intra-aortic balloon pump (IABP), extracorporeal membrane oxygenation (ECMO), and ventricular assist devices (VAD) were the MCS that we investigated. The pre- and post-transplant characteristics and variables of patients bridged with the different types of MCS were collected. The post-transplant survival was compared using Kaplan-Meier survival analysis. RESULTS: A total of 251 heart transplants were reviewed; 115 without MCS and 136 with MCS. The patients were divided to five groups: Group 1 (no MCS): n=115; Group 2 (IABP): n=15; Group 3 (ECMO): n=33; Group 4 (ECMO-VAD): double-bridge (n=59); Group 5 (VAD): n=29. Survival analysis demonstrated that the 3-year post-transplant survival rates were significantly different among the groups (Log-rank p < 0.001). There was no difference in survival between group 4(ECMO-VAD) and group 1(no MCS)1 (p = 0.136), or between group 4(ECMO-VAD) and group 5(VAD) (p = 0.994). Group 3(ECMO) had significantly inferior 3-year survival than group 4(ECMO-VAD) and group 5(VAD). CONCLUSION: Double bridge may not lead to worse mid-term results in patients who could receive a transplantation. Initial stabilization with ECMO for critical patients before implantation of VAD might be considered as a strategy for obtaining an optimal post-transplant outcome.
GWAS Meta-Analysis Reveals Shared Genes and Biological Pathways Between Major Depressive Disorder and Insomnia
Authors: Lin Yi-Sian , Wang Chia-Chun , Chen Cho-Yi
Published: September 2021

Major depressive disorder (MDD) is one of the most prevalent and disabling mental disorders worldwide. Among the symptoms of MDD, sleep disturbance such as insomnia is prominent and the first reason patients may seek professional help. However, the underlying pathophysiology of this comorbidity is still elusive. Recently, genome-wide association studies (GWAS) have begun to unveil the genetic background of several psychiatric disorders, including MDD and insomnia. Identifying the shared genomic risk loci between comorbid psychiatric disorders could be a valuable strategy to understand their comorbidity. This study seeks to identify the shared genes and biological pathways between MDD and insomnia based on their shared genetic variants. First, we performed a meta-analysis based on the GWAS summary statistics of MDD and insomnia obtained from Psychiatric Genomics Consortium and UK Biobank, respectively. Next, we associated shared genetic variants to genes using two gene mapping strategies: (a) positional mapping based on genomic proximity and (b) expression quantitative trait loci (eQTL) mapping based on gene expression linkage across multiple tissues. As a result, a total of 719 shared genes were identified. Over half (51%) of them are protein-coding genes. Functional enrichment analysis shows that the most enriched biological pathways are related to epigenetic modification, sensory perception, and immunologic signatures. We also identified druggable targets using a network approach. Together these results may provide insights into understanding the genetic predisposition and underlying biological pathways of comorbid MDD and insomnia symptoms.
Pancasila Values Education In Learning History In Indonesia
Authors: Pratiwi Erisya Pebrianti
Published: September 2021

Multicultural education with Pancasila values aims to change schools, so that all students can learn about the knowledge, attitudes and skills needs to be applied in countries and worlds that have different races and cultures. Multicultural education with Pancasila values as a new discourse in Indonesia can be implemented not only through formal education, but can also be implemented in daily life in the community as well as in families (nonformal and informal education). In multicultural education, some dimensions need to be considered as well as facts that need to be put forward in connection with the outbreak of conflict in society that if not immediately addressed will be more protracted. Multicultural education can be implied in the world of education where there are seven ways in this article. In implementing Pancasila values with multicultural education in students in schools, as educators and teachers will encounter obstacles or challenges in their implementation. The innovation of historical learning is required in historical subjects in shaping the character of students.
Implementation of Multicultural Education Values In History Learning at SMA NEGERI Siwalima Ambon
Authors: Luturmas Rianko
Published: September 2021

Multicultural education is an educational concept that recognizes differences / diversity in a frame of togetherness and equality. The concept of multicultural education is relevant in the concept of a country that has cultural diversity like Indonesia. Education is one of the effective media to develop multiculturalist awareness. Educational curriculum development must be based on the socio-cultural context of the community. So it must be realized that historical learning has a big role in the development of multicultural education, considering that historical pursuits present various historical facts of the nation which of course have a diversity of identities and cultures. Through identification of historical material contained in the syllabus of history subjects in schools, it is found that some content is loaded with the development of multicultural values.
Improving Quality Of The Understanding Of Pancasila Values And Achievement IN History Learning Through Cooperative Learning Model Picture And Picture Method at SMAN 4 Kupang
Authors: Blegur Margison A.
Published: September 2021

This research aims to improve the understanding of Pancasila values and improve the achievement of learning history in the midst of the identity of the nation. Strengthening historical learning determines how implementation will impact the quality of the nation's identity, by improving the quality of historical learning by planting Pancasila values will impact students in general. The number of negative influences on a country is a fading of sublime values that can be seen in a country, and this is what is happening in Indonesia today, with the influence of globalization one of which is the influence of outside cultures that do not conform to Pancasila values. Through the application of cooperative learning models with picture and picture methods, this research uses class action research methods through two cycles consisting of the introduction, core activities, and cover. The results showed that the cooperative learning method with picture and picture model can improve the understanding of Pancasila values of 3rd graders in SMA N 4 KUPANG. Furthermore, the results of this study are expected to improve the material understanding of Pancasila values continuously in SMA N 4 Kupang NTT.
Learning History Of Islamic Development In Indonesia And The Investment Of Local Values In Sma Negeri 1 Baturetno Wonogiri
Authors: Himawan Anang Harris
Published: September 2021

Education not only teaches understanding material, but also the formation of attitudes and media in preserving local culture. Planting local wisdom is important to apply because it is a means for students to better understand and love the culture they have. This study uses a qualitative method with a narrative approach. The informants in this study were history teachers and students of SMA Negeri 1 Baturetno. Observation data collection techniques, interviews and documentation. The data validity test used technical triangulation and source triangulation. Data analysis techniques with interaction analysis consisting of data collection, data reduction, data presentation, and conclusions. The results showed 1) planting local wisdom in the history of teaching teachers only developed their own learning related to regional culture. The planting of local wisdom tends to be in school activities outside of learning 2) the implementation of local wisdom values carried out by students has gone well. The values of local wisdom include ethics, aesthetics, religion, and social.
Strengthening Historical Awareness Through Learning Based On Tourism Work Of Hindu-Buddhist Historical Sites In Tulungagung
Authors: Tricahyono Danan
Published: September 2021

The purpose of learning history is to make students have historical thinking skills. To achieve historical thinking skills, students need to be equipped with capital to have historical awareness. One of the efforts to instill historical awareness can be done by learning field trip. Field trip implementation by inviting students to visit historical sites. Objects that are used as tourism objects are Hindu-Buddhist sites in Tulungagung. The site is in the form of ancient caves and temples. The purpose of this paper is to provide alternative conceptual ideas for history teachers to strengthen historical awareness through the field trip method. Through well-packaged learning activities, it can provide direct experience for participants to get closer to historical sites. From each site visited there is a story and a red thread will be found in the narrative of the relationship between history and the local context and national history. So that it will lead to an appreciation of the meaning and essence of history that is used for guidance in the present and future life.
Diluwang Ponorogo Narrative As Enrichment Of Materials In Historical Learning Based On Local Wisdom
Authors: Wahyu Itama Citra Dewi Kurnia , Warto Warto , S Leo Agung
Published: September 2021

History learning generally refers to the material in the textbook and does not mention the local history that is around students. As a result, students are less interested and do not understand the historical material presented by the teacher. Lack of knowledge about local history in history learning material has an impact on the fading of the local values of students. The purpose of this study was to identify the use of Dluwang Ponorogo narrative as material enrichment in local wisdom-based historical learning. The method used in this research is qualitative research with data collection techniques in the form of literature studies. The findings of this study resulted in the conclusion that the use of local history in enriching history learning materials can increase the locality of learners. The enrichment of material in historical learning based on local wisdom can be obtained by students by studying the local history of the area where they live. In fact, local history is shaped by the local wisdom of the community and local wisdom itself comes from the culture of a community.
Edutainment Model Implementation Using If History In History Learning (Classroom Action Research at X MIPA 4 SMAN 6 Bandung)
Authors: Ramadhan Fahmi Nur
Published: September 2021

This research were taken based on the low of students' understanding in historical comprehension class. The low students' understanding about history can be seen from the tendency of students that depend on textbooks that make them them cannot develop historical facts more broadly. This research tries to answer some formulation of the problem including how teachers application the learning methods to improve students' understanding of history through edutainment models using if history. The research method used in this research is the Class Action Research method with the research design model Kemmis and McTaggart that consist of the stages of planning, action, observation, and reflection. Based on the results of the research that have been done in three actions, it shows an increase in the understanding of students' history after the application of edutainment models using if history. In action I the writer obtained a score of 41.6%, action II amounted to 55.5%, in action III and IV of 100%. This increase shows that the application of edutainment models using if history is very effective to improve students' historical understanding in history learning.
Nationalism Moh. Hatta through the Sigil Application in History Learning
Authors: Sari Endah Puspita , Agung Leo , Joebagio Hermanu
Published: September 2021

Learning in schools today still uses the method of lectures and the use of Microsoft office power points. The use of teaching materials is still considered less supportive of historical learning in today's schools. Therefore, interesting and effective teaching materials are required, one of which is sigil application. This research aims to encourage the renewal of teaching materials, especially in historical learning. The approach used in this study is a qualitative method. The population used is grade XI students of IPS SMA N 1 Pacitan school year 2019/2020. The type of sample used is simple random sampling technique. Data collection techniques using polls. Based on the results of the study can be concluded: 1) Moh nationalism. Hatta was a nationalism handed over entirely to the people. 2) sigil application is one of the software applications used to create e- books in Epub format. 3) Historical learning using sigil applications can affect students' nationalism.
Implementation Of Character Education In Planting Student Nationalism In The Era Of Independent Learning
Authors: Siswanto Edi
Published: September 2021

Seeing the existing problems with the character crisis in this country, as an effort for social studies teachers to implement character education in instilling the nationalism of students in the era of independent learning. The method used in this research is a qualitative descriptive method, where descriptive research in this case is a study that aims to describe the policy of independent learning as an effort to improve the quality of education and the attitude of nationalism. The results of this study indicate that the attitude of nationalism which is part of the character values really needs to be possessed by students, the role of the teacher is very important in shaping the character of students who have a nationalistic attitude. The teacher's role implementation can be reflected in the teacher's personality, because the teacher is the main factor and influences the learning process of students. The efforts of history teachers in forming students' nationalistic attitudes, namely linking with the scope, historical material and lesson plans for history subjects, the methods used by teachers in instilling the existing values of nationalism. Learning media used by teachers in an effort to form student nationalism attitudes.
Peningkatan Hasil Belajar dan Keaktifan Siswa pada Pembelajaran Tugasku Sehari-hari dengan Menggunakan Model Pembelajaran Make a Match di Kelas II SDN 2 Cingkrong
Authors: Susilowati Susilowati
Published: September 2021

This research was conducted because of the low learning outcomes of grade II at SDN 2 Cingkrong.The method that researchers used in this classroom action research was the Make a Match cooperative learning model in which there were 4 stages, namely planning, action, observation and reflection. The subjects of this study were class II students of SDN 2 Cingkrong which consisted of 26 students. Data collection was carried out. Researchers through observation, interviews, tests and documentation. The results showed that 1) The application of the Make a Match type of cooperative model can increase the activity of teachers and students. On the results of observations of teacher activity in cycle I is 72.52, and increased to 90.32 in the cycle II. Meanwhile, the results of student activity observations in cycle I were 70.83, and increased to 91.7 in cycle II. 2) The increase in student learning outcomes can be seen from the average score of students in the Indonesian language subject at Pre PTK of 63.7 with a percentage of 46.15%, in the first cycle it became 72.7, with a percentage of 69.23%, and increased to 77. , with a percentage of 80.8% in cycle II. Mathematics also increased, namely at the beginning of the cycle of 64.1, with a percentage of 42.30%, in the first cycle it became 695 with a percentage of 57.7% and increased to 77, with a percentage of 80.76. In cycle II.
Improvement of Properties of Gas Objectives Learning Outcomes through Problem Based Learning Models in Primary School
Authors: Wartiah Wartiah
Published: September 2021

Improve learning outcomes and learning motivation material properties of gas objects using the Problem Based Learning learning model for grade III students of SD Negeri 02 Bodas, Watukumpul District, Pemalang Regency, Academic Year 2020/2021. This research is in the form of Classroom Action Research in collaboration with researchers and third grade teachers. To test the validity of the data, the writer used triangulation of data sources and triangulation of methods. The data collection techniques used were documentation, observation and tests. To test the validity of the data used was an interactive analysis model which had three components, namely data reduction, data presentation and conclusion drawing. This study consisted of two cycles consisting of four stages, namely planning, implementing, observing and reflecting. Before the 17% completeness study, the first cycle was 75% complete with an average value of 78.75 and in the second cycle 87.50. It was concluded that the application of the problem based learning model can improve learning outcomes in the material properties of gas objects in elementary school students.
Upaya Peningkatan Hasil Belajar Bahasa Indonesia Melalui Media Video Pembelajaran Pada Siswa Kelas II SD
Authors: Hastuti Dwi
Published: September 2021

The purpose of this study was to improve the learning outcomes of class II students in Indonesian language learning. The research was conducted in three cycles, and each cycle was divided into one meeting. Each cycle consists of planning, implementing, observing and reflecting. Data collection techniques are observation and tests. Based on the data analysis, it was found that the use of video media in Indonesian learning with vocabulary materials and concepts could improve student learning outcomes as indicated by the level of learning completeness in the initial conditions of 30% to 60% in cycle I, and increased to 80% in cycle II. and increased to 85% in cycle III. The final conclusion from the implementation of this classroom action research is that the use of video media is able to improve student learning outcomes in learning Indonesian vocabulary materials and concepts in SD 4 Payaman, Mejobo District, Kudus Reg
Efforts to Improve Mathematics Learning Achievement Through the Make A Match Learning Model in Class III Students of SDN Brebeg 01 Jeruklegi
Authors: Solikhin Fajar
Published: September 2021

This article describes efforts to improve mathematics learning achievement through the make a match learning model for grade III students of SD Negeri Brebeg 01 in the 2020/2021 learning year. This study uses two cycles. Where each cycle begins with planning, implementing, observing, and reflecting. The results of this study were that in cycle 1 there was an increase in pre-cycle, 65.52% of students completed and in cycle 2 there was an increase from cycle 1, 86.94% of students completed from 23 students. These results indicate that the make a match learning model can improve student achievement in determining the place value of a number in class III SD Negeri Brebeg 01.
Improving Student Learning Outcomes in Energy Materials and Their Changes through Demonstrations, Concrete Media in Class V
Authors: Kristiawanto Kristiawanto
Published: September 2021

Based on the formulation of the problem, the research objective to be achieved through the application of concrete media-based methods is to improve science learning outcomes regarding the grouping of magnetic and non-magnetic objects in class V. This research was conducted at SDN 3 Jangkungharjo. The research was conducted in 2 cycles, where each cycle consisted of 4 stages of planning, implementing, observing / observing, and reflecting. The results of the pre-cycle research stated that: out of 32 students, only 10 students (31.25%) obtained complete learning. After the learning improvement process in cycle I, students who obtained learning completeness increased to 20 students (62.50%). The process of improving learning in Cycle II can improve students' understanding with learning outcomes reaching 30 students (93.75%). This increase shows that the methods used in the learning improvement process can be used as a means to improve student learning outcomes.