bluuebunny/crossref_metadata_2025 huggingface dataset:
Short and medium-term effects of the COVID-19 lockdowns on child and parent accelerometer-measured physical activity and sedentary time: a natural experiment
Authors: Jago Russell , House Danielle , Salway Ruth , Walker Robert , Emm-Collison Lydia , Sansum Kate , Breheny Katie , Churchward Sarah , Williams Joanna G , Hollingworth William , de Vocht Frank
Published: September 2023

Background

The COVID-19 pandemic has resulted in marked impacts on children’s physical activity, with large reductions in moderate-to-vigorous physical activity (MVPA) reported during lockdowns. Previous evidence showed children’s activity levels were lower and sedentary time higher immediately post-COVID lockdown, while there was little change in parental physical activity. We need to know if these patterns persist.

Methods

Active-6 is a natural experiment using repeated cross-sectional data conducted in two waves. Accelerometer data were collected on 393 children aged 10–11 and their parents from 23 schools in Wave 1 (June 2021-December 2021), and 436 children and parents from 27 schools in Wave 2 (January 2022-July 2022). These were compared to a pre-COVID-19 comparator group (March 2017-May 2018) of 1,296 children and parents in the same schools. Mean minutes of accelerometer-measured MVPA and sedentary time were derived for week- and weekend-days and compared across waves via linear multilevel models. We also analysed the date of data collection as a time series, to explore temporal patterns via generalised additive mixed models.

Results

There was no difference in children’s mean MVPA in Wave 2 (weekdays: -2.3 min; 95% CI: -5.9, 1.3 and weekends: 0.6 min; 95% CI: -3.5, 4.6) when compared to the pre-COVID-19 data. Sedentary time remained higher than pre-pandemic by 13.2 min (95% CI:5.3, 21.1) on weekdays. Differences compared to pre-COVID-19 changed over time, with children’s MVPA decreasing over winter, coinciding with COVID-19 outbreaks, and only returning to pre-pandemic levels towards May/June 2022. Parents’ sedentary time and weekday MVPA was similar to pre-COVID-19 levels, with MVPA higher than pre-pandemic by 7.7 min (95% CI: 1.4, 14.0) on weekends.

Conclusion

After an initial drop, children’s MVPA returned to pre-pandemic levels by July 2022, while sedentary time remained higher. Parents’ MVPA remained higher, especially at weekends. The recovery in physical activity is precarious and potentially susceptible to future COVID-19 outbreaks or changes in provision, and so robust measures to protect against future disruptions are needed. Furthermore, many children are still inactive, with only 41% meeting UK physical activity guidelines, and so there is still a need to increase children’s physical activity.
Morpho-physiological and hormonal response of different winter wheat varieties to drought stress at germination and seedling stage
Authors: Duvanjak Jurica , Brkljačić Lidija , Salopek Sondi Branka , Španić Valentina
Published: September 2023

Drought stress can have a significant influence on the reduction of wheat (Triticum aestivum L.) growth and development. This study investigated morpho-physiological, abscisic (ABA) and salicylic (SA) acids' responses of six winter wheat varieties (Rujana, Silvija, Fifi, Bubnjar, Anđelka and Pepeljuga) during the germination and seedling stage. Plants were exposed to 10 and 20% polyethylene glycol (PEG) solution for seven days. Certain morphophysiological changes were observed under stress condition in comparison to controls, such as a reduction of germination energy (GE), shoot length, relative water content (RWC), increase of root growth, depending on varieties and stress intensity. ABA was increased in all cultivars confirming stress status of the plants. SA showed a tendency to decrease depending on the concentration of PEG and was positively correlated with shoot length and shoot dry weight. In the varieties Rujana, Anđelka, Fifi and Bubnjar a less significant decrease in germination energy was recorded, compared to Pepeljuga and Silvij
Sadašnje stanje i prijedlog uređenja parka Sv. Marina na Loparu-otok Rab
Authors: Španjol Željko , Gašparović Ivana , Dorbić Boris , Paparić Dominik , Rosavec Roman , Šango Mario
Published: September 2023

U današnje vrijeme građani i turisti sve više vole što prirodniji krajobraz za svoj odmor i rekreaciju. To mogu biti šumski predjeli, park šume, parkovi i druge površine s određenim više ili manje uređenim biljnim pokrovom. Nekim takvim predjelima je zbog posljedica neodržavanja smanjena ukupna estetska i funkcionalna vrijednost. Cilj ovog rada je inventarizacija sadašnjeg stanja dendroflore te dati prijedlog uređenja cjelokupnog prostora s prijedlogom kao dopuna postojećoj dendroflori parka Sv. Marina koji predstavlja značajni, dijelom antropogenizirani prirodni krajobraz koji se nalazi u istočnom dijelu općine Lopar na otoku Rabu i zauzima površinu od 4,75 ha. To je područje koje je prije jednog stoljeća pošumljeno i danas dijelom u funkciji urbane šume i parka. U njemu se ne provode šumarske hortikulturne mjere održavanja i njege što je dovelo do prirodne sukcesije šumske vegetacije. Cijelo područje predstavlja veliki prostorni i prirodni potencijal da ga se uredi i određenim sadržajima osmisli. Na osnovi biološko-ekološke i prostorne analize i mogućim funkcionalnim gospodarskim razvojem ovog prostora analizirano je ranije izrađeno idejno rješenje cjelokupnog prostora koji je definiran u tri funkcionalne, ali povezane zone: hotel, plato (trg), park. Novo uređenje cjelokupnog područja i parka kroz dano idejno rješenje prožeto je tradicionalnim mediteranskim duhom uz upotrebu lokalnih stilskih obilježja (biljni materijali i vrtno-građevinski elementi). Ono se također poklapa s namjenom sukladno prostorno planskim rješenjima. Uređenjem ovog područja dobiva se prostor od turističkog i sociološkog značaja.
Динаміка товарної структури штучних соснових деревостанів Слобожанського лісотипологічного району
Authors: Пастернак В. П. , Гірс О. А. , Гармаш А. В.
Published: September 2023

Досліджено розподіл соснових деревостанів Слобожанського лісотипологічного району за походженням, типами лісу, повнотою та продуктивністю. Здійснено аналіз лісівничо-таксаційних показників на дослідних ділянках. Розглянуто таксаційну будову та товарну структуру соснових деревостанів регіону дослідження. Розраховано моделі мінливості діаметрів і відношення мінливості ділової частини до загальної мінливості діаметра деревостану з урахуванням мінімального та максимального діаметрів у модальних деревостанах. Виявлено залежність між часткою ділових стовбурів і віком модальних соснових деревостанів штучного походження. Побудовано таблиці динаміки товарної структури модальних соснових деревостанів із урахуванням розподілу об’ємів ділових стовбурів за класами й підкласами товщини, узгодженими з європейськими підходами щодо таксації круглих лісоматеріалів. Для складання нормативів застосовували нормативи ходу росту модальних сосняків штучного походження Лівобережного Лісостепу. Під час порівняння розроблених для Слобожанського лісотипологічного району нормативів з нормативами, розробленими для штучних соснових деревостанів Придонецького Степу, виявлено, що в останніх вихід ділової деревини нижчий у зв’язку з лісорослинними умовами регіону та станом деревостанів.
Динаміка реалізації ділової деревини в Україні під час воєнного стану
Authors: Жежкун І. М.
Published: September 2023

Наведено перелік основних негативних наслідків війни для економіки лісового господарства України. Обґрунтовано доцільність використання вибіркового методу економічного аналізу під час війни та визначено пов’язані з нею ускладнення щодо отримання необхідної статистичної інформації. Розглянуто квартальну динаміку фізичних обсягів і цін реалізації сортиментів лісоматеріалів круглих сосни та дуба за чотирма (А, В, С, D) класами (діаметром 30–34 см, умови відпуску – франко-нижній склад і франко-ліс) упродовж 2022 р. за обласними управліннями лісового та мисливського господарства Державного агентства лісових ресурсів (ДАЛРУ) та здійснено порівняння з даними IV кварталу 2021 р. Визначено загальні тенденції змін і відмінності динаміки зазначених показників за підприємствами, підпорядкованими ДАЛРУ, за головними породами, класами якості та умовами відпуску деревини протягом першого року широкомасштабної військової агресії Росії в Україні.
Пріоритетність споживання мисливськими ратичними тваринами дерев і чагарників у лісах Полісся й Лісостепу
Authors: Гулик І. Т. , Шевчук В. В. , Шейгас І. М.
Published: September 2023

Дослідженнями, проведеними в лісах Полісся та Лісостепу України, визначено пріоритетність споживання, частку і ступінь пошкодження мисливськими ратичними тваринами кормових дерев і чагарників у зимовий період на прикладі одного з найрозповсюдженіших та найчисленніших в Україні видів мисливських жуйних ратичних тварин – козулі, або сарни європейської (Caprelus capreolus L.). Отримані результати можуть бути використані для оцінювання придатності угідь для перебування ратичних, визначення кормової ємності та класу бонітету мисливських угідь, розрахунку щільності тварин в угіддях, а також дадуть змогу визначати перелік пріоритетних кормових стацій козулі у цей період року.
Посухостійкість десяти клонів тополі на сході України
Authors: Висоцька Н. Ю.
Published: September 2023

Інтерпретація реакції клонів тополь на дію дефіциту вологи дає можливість визначити найкращі гібридні комбінації для виявлення генотипів із високою стійкістю до посухи. Оцінено посухостійкість десяти клонів тополь у віці 7 років, які ростуть у сортовипробних культурах на сході України. Дослідження проведено в лабораторних умовах шляхом оцінювання вмісту води в тканинах листя, водного дефіциту, здатності листків утримувати воду та електропровідності. Клони 'Перспективна' (P. ? euroamericana cv. 'regenerata' ? P. lasiocarpa), 'Львівська' (P. ? euramericana cv. 'regenerata' ? P. trichocarpa), 'Ноктюрн' (P. trichocarpa ? P. lasiocarpa) виявилися стійкими до посухи. Клони 'Dorskamp' (P. ? euramericana var. Dorskamp) і 'Дружба' (P. trichocarpa ? P. laurifolia) були найменш посухостійкими. Гіпотезу про вищу посухостійкість клонів тополь, які культивують на сході України з 1960-х років, не підтверджено. Не виявлено залежності посухостійкості від гібридних комбінацій батьківських форм.
Evolution of Neurosurgery in Bangladesh
Authors: Hossain M Afzal
Published: September 2023

Abstract not available
Bang. J Neurosurgery 2022; 12(1): 1-2
A Success Story of Cerebral Arteriovenous Malformation (AVM) Treated with Stereotactic Radiosurgery (SRS) in Bangladesh
Authors: Kumar Narendra , Yasmin Taohida , Appasamy Murugan , Rana KM Masud , Kumar R Arun , Joardar Aliuzzaman , Ahsan Sania , Alam Saiful
Published: September 2023

Purpose: To share a case of cerebral Arteriovenous Malformation (AVM) patient, treated with Stereotactic Radiosurgery (SRS) at Evercare Hospital Dhaka, treatment process and successful outcome.
Background: Arteriovenous malformation is an anomaly, mostly congenital due to a misfit in vasculogenic, where arteries and veins come to a direct connection. Treatment options include observation, embolization, microsurgery, Stereotactic Radiosurgery (SRS) either alone or in combination. This report describes our experience in treating a patient of AVM by SRS. Stereotactic Radiosurgery is an established modality to achieve desired nidus obliteration, excellent compliance being noninvasive, and reduced treatment-related morbidity. This case report also reviewed the literature in detail. After a thorough literature search, to the best of our knowledge, this shall be the first published case report of AVM successfully treated with SRS in Bangladesh. 
Case Presentation:  In March 2019, 25-years old male presented in Radiation Oncology OPD as a diagnosed case of AVM, having complaints of headache for two years. Headache was occasional and often associated with vertigo and dizziness. He had no neurologic deficit. A radiological assessment revealed a large (4.6x4.4cm) AVM in the left parieto-occipital lobe showing serpiginous enhancement with IV contrast. After routine workup, he underwent stereotactic Radiosurgery in March’2019. A dose of 23Gy was delivered to the malformation, including all nidus. Acute radiation toxicity was noted as transient hair loss only over the irradiated area and no other side effect.  Radiological Assessment was done at six months, 1year, and 2.5 years. After having a stable size at six months, complete nidus obliteration was achieved at one year. His last visit to our OPD was in July 2021, with radiologically complete nidus obliteration without any significant clinical symptoms.  
Conclusions: Linear Accelerator-based SRS is an excellent treatment option for AVM, encouraging clinical outcomes for carefully selected patients.
Bang. J Neurosurgery 2022; 12(1): 53-64
Perawatan Pasien Stroke Dengan Terapi Komplementer Dan Alternatif Di Rumah: Studi Fenomenologi
Authors: Susanti Risqi Wahyu , Baeda Abd Gani , Saputri Ekawati
Published: September 2023

A stroke is a brain attack that can result in disability. It is scarce to know the integration between complementary and alternative therapy into conventional treatment for stroke survivors. Indonesia has various complementary and alternative therapies due to the length of the country then it is necessary to know any types of complementary and alternative therapy used by patients. The study aims to explore the treatment of stroke patients using complementary and alternative therapies. The qualitative design with a phenomenological approach was used. Data were collected through in-depth interviews with eight families with stroke survivors according to the inclusion criteria and using source triangulation. The sampling technique used was purposive sampling. A selective analysis approach and focus are used for data analysis. Results showed there were three themes derived including types of complementary and alternative therapy, method of manufacture, method of administration, and therapeutic dose. Types of complementary and alternative therapies used by the participant include herbal therapy, massage, exercise, magnetic therapy, light therapy, thalassotherapy, electrical stimulation, and diet. Further research is needed to test the effectiveness, dosage, and safety procedures to combined with conventional treatment.
Usia Berhubungan Dengan Preeklampsi Pada Ibu Hamil di Puskesmas Cipamokolan Bandung
Authors: Jayanti Tri Nur , Rustikayanti R Nety , Tambunan Irisanna
Published: September 2023

Preeclampsia is a systemic disorder 20 weeks of gestation, characterized by a BP 140/90 mmHg and proteinuria. These abnormalities can affect both the mother and fetus. The cause of preeclampsia was still unknown. Several studies have reported different results regarding the risk factors associated with preeclampsia. Therefore, research about the factors that influence preeclampsia at the Cipamokolan Health Center needs to be carried out to determine further prevention programs. The case-control was used as the study design. The population is all pregnant women data in the Cipamokolan Health Center during the past year. The study sample was taken by purposive sampling based on the specified criteria. A total of eighteen respondents were recruited in the case group and 97 respondents in the control group. Data obtained secondary from medical records. The data were analyzed using the Chi-Square. The results showed a relationship between maternal age and preeclampsia (p-value = .036 .050), and there was no relationship between gravidity and pregnancy intervals with preeclampsia in pregnant women at the Cipamokolan Health Center. A pregnancy spacing program is recommended to avoid preeclampsia during pregnancy.
Faktor-Faktor Yang Mempengaruhi Kelengkapan Imunisasi Dasar Pada Bayi Di Posyandu Dewi Sartika Kota Malang
Authors: Maemunah Neni , Susmini Susmini , Tuanany Nona N
Published: September 2023

The reasons behind most of the mothers' refusal to fully immunize their children include a lack of understanding about the immunization process, including an ignorance of the recommended vaccination schedule, the value of immunization, the best time to immunize, and fear of adverse reactions. The study's purpose was to understand the factors that affect the basic vaccination of babies in Posyandu Dewi Sartika Kota Malang. This research is quantitative, with the research design being cross-sectional. The population of 40 mothers who have babies aged 0–12 months in Posyandu Dewi Sartika Kota Malang in 2021. Samples of 40 were recruited using total sampling techniques. The questionnaires were used to collect information about the mother's occupations, knowledge, attitudes, education, experience, health, and age. Data were analyzed using a multiple linear regression test (significance value of p  0,05). The results showed that the mother’s occupation (p = 0,031), knowledge (p = 0,005), attitude (p = 0,027), education (p = 0.031), experience (p = 0,022), health information, and age (p = 0,019) simultaneously influenced the completeness of basic immunization. The most dominant factor was the knowledge factor (p = 0,005). Further research to explore the effect of cultural factors and motivations of mothers when providing fully basic vaccinations to babies is expected.
Pengembangan Aplikasi Relaksasi Guided Imagery Berbasis Android Untuk Tingkat Stres Pada Pasien Pra Lansia dengan Hipertensi
Authors: Sari Purwanti Nurfita , Haryanto Joni , Sari Dianis Wulan
Published: September 2023

Chronic stress in hypertensive patients results in fatal complications. Information technology is more effective than face-to-face communication for stress management. It has been demonstrated that media technology is more appealing, of high quality, effective, and efficient. The goal of this study is to create a guided imagery app for Android that will help pre-elderly hypertensive patients feel less stressed. A research and development design was used for this project. In addition to application development through focus group discussions and professional consultations, as well as assessing the viability of utilizing the application, exploration of stress levels and evaluation of stress management are monitored. The study's older participants, who ranged in age from 45 to 59, had hypertension. 50 patients were involved in phase 1 data collecting utilizing the perceived stress scale questionnaire. 30 patients in phase 2 used a system usability scale questionnaire, which was modified and tested for validity again with 10 respondents. The inclusion criteria for primary hypertension patients undergoing treatment were pre-elderly, aged 45–59 years old, male and female, Muslim, able to read and write, own a smartphone and be able to operate it, and have no visual or hearing limitations. Purposive sampling was used and data was analyzed using descriptive data analysis. The results show a moderate level of stress (62%). The results of the due diligence got a value of 80.66 (good and proper). The development of an Android-based guided imagery relaxation application can be recommended to pre-elderly hypertensive patients as a medium that can be used independently at home to help control stress levels.
Penguatan Pemetaan Partisipatif Menuju Kampung Berdaya berbasis Geospasial di Kampung Ekowisata Ciwaluh, Kabupaten Bogor
Authors: Permana Mirza , Hidayah Ulul , Pamungkas Guntur Bagus , Putri Erika Pradana
Published: September 2023

Indonesia kaya akan desa wisata dengan daya Tarik tersendiri. Kampung Ekowisata Ciwaluh merupakan salah satu desa wisata di Kabupaten Bogor dengan jumlah kunjungan wisatawan yang semakin meningkat. Kegagahan lanskap di bawah kaki Gunung Gede Pangrango dan alam yang masih alami menjadi daya tarik dari Kampung ekowisata Ciwaluh. Sejak berdiri tahun 2009, hingga saat ini pengembangan pariwisata di kampung ini belum terencana dengan baik. Sebagai langkah awal untuk mewadahi keterlibatan masyarakat dalam perencanaan pengembangan desa wisata di Kampung Ekowisata Ciwaluh, dilaksanakan kegiatan pengabdian masyarakat berupa pemetaan partisipatif. Metode pelaksanaan pemetaan partisipatif pada kegiatan pengabdian diawali dengan mengajarkan penggunaan alat GPS kepada masyarakat, kemudian masyarakat melakukan pemetaan data koordinat desa, lalu validasi data tersebut dengan melibatkan masyarakat. Hasil kegiatan pengabdian ini berupa data spasial berupa akses wisata, batas kampung, dan rumah warga yang dijadikan homestay. Selain itu, kegiatan pengabdian masyarakat ini juga memfasilitasi dua buah GPS yang dapat dimanfaatkan masyarakat Kampung Ciwaluh. Pengenalan dan pembekalan pemanfaatan GPS tersebut dimaksudkan agar masyarakat Kampung Ekowisata Ciwaluh semakin melek teknologi dalam kegiatan digitalisasi data kampung. Antusiasme masyarakat kampung ekowisata ciwaluh khususnya pokdarwis untuk belajar menggunakan GPS cukup tinggi.
Identification and Quantitative Determination of Flavonoids by HPLC-UV Method in the Raw Materials of Some Representatives of the Genus Rumex of Three Vegetation Time
Authors: Poluyanov A. M. , Sokolova A. Yu. , Koynova A.-D. , Kulikova S. D. , Malashenko E. A. , Bobkova N. V.
Published: September 2023

Introduction. The study of the dynamics of accumulation of biologically active substances (hereinafter – BAS) in relation to the phonological phases of plant development is of great scientific and practical interest. The quantitative content of aglycones and glycosides of flavonoids depends on the life cycle of the plant and its vegetation phase.

Aim. To identify and quantify flavonoids in the underground organs of Rumex confertus Willd., Rumex aquaticus L., Rumex crispus L. and Rumex obtusifolius L. harvested during different phases of vegetation.

Materials and methods. Extracts from the underground organs of the studied plants, obtained according to the method from the pharmacopoeial article on R. confertus, were analyzed. Chromatographic separation and detection were performed on a Nexera-i LC-2040 high-performance liquid chromatograph (Shimadzu Corporation, Japan). The chromatograph was equipped with a column thermostat, chromatography column Grace HPLC-COLUMN 250 × 4.6mm platinum C8-EPS 5 mm (Grace, США) and Guard column Phenomenex SecurityGuardTM Cartridges Widepore C18 4 × 3,0 mm, a degasser, an autosampler (injection volume: 10 µl), and an ultraviolet detector. Detection was carried out at a wavelength λ = 365 ± 2 nm. Mobile phase contains 0.1 % phosphoric acid in water (v/v) (eluent A); acetonitrile (eluent B) with flow rate: 0.9 ml/min.

Results and discussion. All studied objects were analyzed. The authenticity of the substances contained were confirmed using the external standard, and their quantitative content was determined. The discovered and quantified substances were: 3-O-rutinoside of quercetin (rutin), 3-O-rutinoside of isorhamnetin (narcissin), 3-O-glucoside of kaempferol (astragalin), luteolin, kaempferol and isorhamnetin. 7-O-glucoside of luteolin (cynaroside) and 7-O-beta-D-glucoside apigenin (cosmosiin) were not found. The aglycone luteolin had the biggest share in the total quantitative content of flavonoids. It is noted that this aglycone is contained in larger quantities in relation to other flavonoids in all studied objects, regardless of the phase of vegetation.

Conclusion. In the process of the research, a method for the quantitative determination of flavonoids in alcohol-water extracts was developed. Aglycones and glycosides of flavonoids were identified and quantified in the underground organs of R. confertus Willd., R. aquaticus L., R. crispus L. and R. obtusifolius L. of three different vegetations.
Antiarrhythmic Activity of Amino Acids Containing Nibentan Derivatives in Case of Symptoms of Occlusive and Reperfusion Arrhythmias
Authors: Napalkova S. M. , Buyuclinskaya O. V.
Published: September 2023

Introduction. Pharmacotherapy of cardiac arrhythmias is one of the urgent problems of modern medicine. The presence of serious side effects, in particular proarrhythmic action, limits the use of known antiarrhythmics in clinical practice. One way to reduce the toxicity of pharmacological agents is to use them as complex compounds with amino acids.

Aim. Studying the effect of nibentan derivatives containing magnesium salt of L-aspartic acid and glycine as anions on the course of early occlusive and reperfusion arrhythmias.

Materials and methods. Aminоacid derivatives of nibentan have been studied in models of occlusive and reperfusion arrhythmias in rats. The activity of the drugs was assessed by the incidence of ventricular extrasystoles (VEC), ventricular tachycardia (VT), ventricular fibrillation (VF), by the latent period and duration of arrhythmias, the average duration of VT, and by the number of VEC per 1 animal.

Results and discussion. Nibentan derivatives in models of early occlusive and reperfusion arrhythmias were not inferior in antiarrhythmic activity to lidocaine and nibentan in their ability to prevent cardiac arrhythmias. The nibentan derivative containing the magnesium salt of L-aspartic acid (compound LHT-53-91) in the model of occlusive arrhythmias at a dose of 2 % LD50 completely prevented cardiac arrhythmias in experimental animals. A nibentan derivative containing glycine (compound LHT-20-92) at a dose of 1 % LD50 significantly reduced the number of cases of PVCs, prevented the occurrence of ventricular tachycardia and ventricular fibrillation in 100 % of cases. In the model of reperfusion arrhythmias, LHT-53-91 at a dose of 1 % LD50 prevented the development of ventricular fibrillation and paroxysms of ventricular tachycardia and reduced the risk of developing ventricular extrasystole (p < 0.05). Increasing the dose to 2 % LD50 led to an increase in the activity of the substance, which was expressed in the prevention of cardiac arrhythmias in 100 % of the animals. LHT-20-92 at a dose of 1 % LD50 in this model of cardiac arrhythmias statistically significantly reduced the occurrence of VES and VT paroxysms and completely prevented the occurrence of VF (p < 0.05).

Conclusion. The inclusion of nibenthan amino acids in the structure, which shielded genotic grouping and reduced potential teratogenicity and mutagenicity, had not led to a reduction in the antiarrhythmic and antifibril-torn activity on the studied models of rhythm disorders.
The Quality Risk Assessment of Paralithodes Camtschaticus Collagenase Gel in the Process of Pharmaceutical Development
Authors: Ivankova Ju. O. , Sysuev B. B. , Evseeva S. B.
Published: September 2023

Introduction. The manufacturing and application of enzyme preparations in the semisolid topical products has features associated with their lability. In previous studies, on the set of specifications the gel form was selected, containing aerosil and olive oil, in which the stabilization of collagenase from Paralithodes camtschaticus was ensured by lipophilic base. In the pharmaceutical development process, the drug critical quality attributes must be defined. Taking into account the lability of Paralithodes camtschaticus collagenase, the identification and minimizing risks аre relevant.

Aim. The aim was the risk factors assessment and minimization during the pharmaceutical development of the gel, containing Paralithodes camtschaticus collagenase within the QbD concept.

Materials and methods. The laboratory samples of gels, containing Paralithodes camtschaticus collagenase, were tested, using the analysis methods recommended by the SP RF 14th ed., as well as GOST 29188.3-91.

Results and discussion. Based on the potential critical characteristics of the material, the pharmaceutical substance Paralithodes camtschaticus collagenase (particle size) and excipients (concentration and sorption properties of aerosil, oxidation of olive oil) risk factors were assessed, and potential measures to reduce these risks are considered. It was revealed that the substance particle size in its origin exceeds the norm and requires preliminary grinding. The aerosil content factor was reveal as critical. The sorption properties of aerosil were not affected the proteolytic and collagenolytic activity of the collgenase gel. It was proved that chemical instability of oil refers to critical factors and the antioxidants (alpha-tocopherol or butylhydroxytoluene) content was justified.

Conclusion. In the course of the study, the Paralithodes camtschaticus collagenase gel the possible risks of pharmaceutical substances and excipients were theoretically justified in accordance with the QbD concept. An experimental assessment of their possible impact on the gel quality was given, which can improve the finished product quality during manufacturing manufacturing by eliminating the identified risks.
Development of the Composition and Technology of Tablets Based on Astragalus membranaceus (Fisch.) Bunge Dry Extract
Authors: Aroyan M. V. , Lohmatova D. E. , Vantorina D. D. , Novikova E. K. , Kaukhova I. E. , Nechaev M. V.
Published: September 2023

Introduction. Human performance depends on external and internal factors. Of a number of external factors, the environmental aspect is one of the leading ones. Internal factors are interrelated with external ones. The latter include the general condition of the human body, as well as the normal functioning of individual systems and organs. It must be noted that the use of herbal drugs in order to prevent the development of pathologies caused by internal factors is rational. A number of plants contain substances that can improve performance by strengthening the cardiovascular system, normalizing the liver, adjusting daily rhythms, reducing stress. In this regard, the development of the composition and technology of drugs based on substances of plant origin does not lose relevance.

Aim. Development of the composition of solid oral dosage form based on dry extract of Astragalus membranaceus (Fisch.) Bunge containing saponins.

Materials and methods. As an object of research, a substance was used – dry extract of Astragalus membranaceus (Fisch.) Bunge, standardized in accordance with the requirements of SP XIV ed. Lactose monohydrate, calcium stearate, methylcellulose, corn starch, talc were used as excipients in the tablet technology. Under laboratory conditions, granulation was carried out by the wet mass extrusion method. A 3 % methylcellulose solution was used as the wetting reagent. Quality parameters of the final dosage form, tablets, were determined according to the methods described in SP XIV ed.

Results and discussion. As a result of the conducted research, the composition of a solid oral dosage form based on a dry extract of Astragalus membranaceus (Fisch.) Bunge was proposed. The main quality indicators of the obtained dosage form are determined. A design quality specification has been developed for a drug.

Conclusion. The present study proposed technology dry extract for Astragalus membranaceus (Fisch.) Bunge herb. Quality index of the obtained plant substance are determined. The composition and technology of tablets based on the dry extract of Astragalus membranaceus (Fisch.) Bunge herb have been developed. The main quality indicators of tablets based on the dry extract of Astragalus membranaceus (Fisch.) Bunge herb were determined. A draft quality specification of the resulting dosage form has been developed.
Persicaria lapathifólia: Identification, Chemical Composition, Pharmacological Action, Prospects for Use in Medical Practice (Review)
Authors: Gudkova A. A. , Chistyakova A. S. , Kostyleva A. A. , Bolgov A. S. , Slivkin A. I.
Published: September 2023

Introduction. Knotweed (curlytop knotweed (curly pea)) – Persicaria lapathifólia Delarbre belongs to the buckwheat family Polygonaceae Juss., the genus Persicaria Mill. For a long time, the Persicaria lapathifólia did not exist as a separate species since 1989, the sorrel-leaved mountaineer has become an independent species. This is an annual herbaceous plant, repeating the main features of the genus Persicaria, and, as the main differences, having larger leaves, most often whitish-green flowers collected in dense inflorescences, peduncles and perianth of which have a large number of yellowish glands and a specific sweet smell.

Text. Purpose of the work was to study the possible prospects for using the Persicaria lapathifólia as an official species. Currently, the plant is not used in medical practice and is considered an admixture in the collection of pharmacopoeial species of the genus Persicaria Mill. The plant is unpretentious to environmental conditions, is a weed, growing in absolutely all climatic zones, which indicates a rich procurement base. Despite the morphological similarity of the mountaineer sorrel with other species of the genus Persicaria, there is a sufficient amount of information in the literature regarding the identification of the object obtained as a result of a comprehensive morphological and anatomical assessment by microscopic methods (stereomicroscopy, luminescent microscopy, classical anatomy, petiolar anatomy), which allows a high the degree of reliability to eliminate errors in the procurement of raw materials and their further use. The chemical composition of Persicaria lapathifólia is represented by various classes of biologically active compounds, among which the most interesting are phenolic compounds (flavonoids), represented mainly by glycosides of quercetin and kaempferol. In addition, the plant is rich in vitamins, being a source of choline, organic and essential amino acids. Taking into account the peculiarities of the component composition of the mountaineer sorrel, the plant is considered as a source of phytopreparations with hemostatic, capillary-protective, antitumor, anti-inflammatory, antifungal effects.

Conclusion. As a result of the generalization of the data available in the literature, the prospects of Persicaria lapathifólia to be introduced as a medicinal plant material and medicinal plant substance for the production of herbal medicines along with Persicaria maculosa and Persicaria hydropiper herb were revealed.
Hubungan self regulated learning dan hasil belajar matematika peserta didik kelas V SDN Ceger 02
Authors: Khairunisa Destia , Umri Umri , Aqida Debby Silvia
Published: September 2023

Self regulated learning dipilih oleh peneliti guna mengukur kemampuan belajar peserta didik walaupun sarana dan prasarana yang dimiliki peserta didik terbatas, sehingga dapat mengetahui hubungan self regulated learning dan hasil belajar matematika peserta didik kelas V SDN Ceger 02. Penelitian ini menggunakan metode kuantitatif dengan desain korelasi. Penelitian ini dilakukan di SDN Ceger 02 dengan sampel 29 peserta didik. Pengambilan data dilakukan dengan menggunakan instrument berupa angket self regulated learning dengan model skala likert dan tes hasil belajar matematika berbentuk pilihan ganda. Hasil penelitian ini menunjukkan bahwa terdapat hubungan yang positif dan signifikan antara self regulated learning dan hasil belajar matematika peserta didik SDN Ceger 02 dengan nilai r hitung atau pearson correlation sebesar 0,574 dengan nilai signifikansi 0,002 yang artinya semakin tinggi nilai self regulated learning peserta didik, maka semakin tinggi juga hasil belajar matematika peserta didik kelas V SDN Ceger 02, begitupun sebaliknya. Besarnya nilai koefisien determinasi pada penelitian ini adalah sebesar 32,95% dan sisanya sebesar 67,05 dipengaruhi oleh faktor lain. Kesimpulan dari penelitian ini yaitu terdapat hubungan yang positif dan signifikan antara self regulated learning dan hasil belajar matematika peserta didik kelas V SDN Ceger 02.
Power Performance Evaluation of Standalone Renewable Energy Source Energy Management Using Pass Filter
Authors: Sulistiyowati Indah , Jamaaluddin Jamaaluddin , Anshory Izza
Published: September 2023

Hybrid energy storage systems have shown promise in enhancing solar panel systems reliability and efficiency. However, managing the power distribution balance with multiple energy storage units remains a challenge. This research addresses power distribution balancing during solar irradiation intermittency by employing a first-order filter with lowpass and highpass characteristics. The study aims to investigate energy and power management issues for off-grid electrical systems using this filter. Results from numerical simulations and experiments with a hybrid energy storage setup comprising a battery and supercapacitor show that the first-order filter effectively allocates the first-order signal to the main energy storage and subsequent orders to the supporting energy storage. During increased intermittency, the battery contributes 62 W and stores 387 W, while the supercapacitor contributes 167 W and stores 297 W. Conversely, during reduced intermittency, the battery stores 390 W and contributes 62 W, and the supercapacitor stores 295 W and contributes 164 W. The findings demonstrate the filter's efficacy in optimizing power distribution balance within hybrid energy storage systems. However, using the supercapacitor as the main energy storage does not result in higher power efficiency compared to the battery. In conclusion, the First Order Filter presents a viable solution for addressing power distribution challenges in hybrid energy storage systems, contributing to improved energy and power management for off-grid electrical systems. Further research on cost-effectiveness, maintenance, and environmental impact is warranted for practical implementation
Analysis of Brain Wave Activity Realtime Using NeuroSky Sensors With LabVIEW
Authors: Pratama Destra Andika , Anisah Masayu , Pratama Richi Agung
Published: September 2023

The brain is the part of the body that gives us the ability to live, react to all external stimuli, and coordinate our entire body. The human brain constantly generates electrical impulses. These electric currents are often referred to as brain waves. EEG (electroencephalography) is a bioelectrical measurement used in the biomedical field to study the human brain. Through this research, a sensor system will be developed that can detect brain waves non-invasively and transmit signals wirelessly via a Bluetooth connection. The detected EEG signal will be displayed in graphical form using signal parameters. To obtain brain wave signals, sensor electrodes are placed directly on reference points on the surface of the scalp in the front and left ears. The captured brainwave signal will be wirelessly transmitted via USB Bluetooth BLE 4.0. Next, the brainwave signal data will be converted and processed via USB Bluetooth BLE 4.0, which is connected to the USB port on the laptop. Then, the brain wave signal will be displayed in graphical form in real-time and analyzed using LabVIEW software. The results of this study indicate that the monitoring system that works on LabVIEW can display real-time data from the NeuroSky sensor wirelessly, and the type of brain waves and the frequency of the resulting brain waves can vary depending on the condition of the brain at the time
Electricity Potential by Bioethanol Fuel from Pineapple Skin Waste, Kualu Nanas Village, Kampar Regency, Riau
Authors: Bijaksana Varkhan , Miefthawati Nanda Putri
Published: September 2023

Kualu Nenas was a pineapple producer in Riau who produced 4 tons of pineapples a day. This production produced 36 tons of waste per month. This waste created problems for the environment, including odor and methane gas, whereas pineapple peel waste included glucose, which can be used to produce bioethanol. This study aimed to analyze the bioethanol potential of pineapple peel and the potential for electricity and power, calculate the values of TFC and SFC, and determine the efficiency of the fuel mixture, which was tested on an 8 kW generator in 30 minutes. This research uses fermentation and distillation methods, which are simulated by a superpro designer. From the research conducted, the potential for bioethanol was 6,262.63 L/month or 68,871.54 L/year with an ethanol content of 99.9995% and 0.0005% water. The electricity is 75.39 MWh/month for E0, 71.98 MWh/month for E10, and 46.88 MWh/month for E100. The power potential generated is 3.14 MW/month for E0, 2.99 MW/month for E10, and 1.95 MW/month for E100. From testing with an 8 kW generator, the TFCs of E0, E10, and E100 fuels were 0.834, 0.835, and 0.839 liters/hour, respectively. While the SFC of E0, E10, and E100 fuels were 0.1043, 0.1044, and 0.1049 liters/hour, with efficiencies of 50.82%, 52.98%, and 80.95%.
Correlation of Sunlight Intensity and Output Voltage on Collector Plate-based Cascaded Thermoelectric Generator Modules
Authors: Djafar Zuryati , Halim Abdul , Mustofa Mustofa , Latif Lita Asyriati , Piarah Wahyu Haryadi
Published: September 2023

The intensity of solar energy is an important factor in viewing the performance of the thermoelectric generator (TEG). Most studies only look at the effect of treatment on the TEG module in the form of cooling mode and its materials. Therefore this study examines the effect of the solar intensity value on the magnitude of the module voltage. On the hot side of the module are placed heat absorber plates of copper, Fe and aluminum plates as well as non collector plates. Modules are cascaded and connected in series as many as 14 modules per plate, so that a total of 56 TEG modules are used. Data collection is carried out simultaneously on all plates. The test results show that the increase in solar intensity is liner with the magnitude of the TEG module voltage or in other words the correlation is positive. The data also shows that copper collector plates produce the highest voltage difference, followed by Ferro, Alumina and no-plates at ∆V 0.871, 0.805; 0.369 and 0.153 V, respectively
Lise Öğrencilerinin Benlik Saygıları ile Beden Eğitimi ve Spor Dersine İlişkin Tutumları
Authors: Aydoğan Hayri , Kurt Hakan
Published: September 2023

Bu çalışmada, lise öğrencilerinin benlik saygıları ile beden eğitimi ve spor dersine ilişkin tutumları arasındaki ilişkinin incelenmesi amaçlanmıştır. Araştırma evrenini 2021-2022 eğitim öğretim yılındaki Doğu Karadeniz Bölgesi Fen Lisesi öğrencileri oluşturmaktayken; örneklemini bu okullarda öğrenim gören basit tesadüfi örnekleme yöntemi ile belirlenen 383 gönüllü öğrenci oluşturmaktadır. Araştırmada verilerin toplanması “Demografik Bilgi Formu”, “Coopersmith Benlik Saygısı Envanteri” ve “Ortaöğretim Öğrencileri İçin Beden Eğitimi Dersi Tutum Ölçeği” ile sağlanmıştır. Veri analizleri SPSS 26.0 lisanlı paket program kullanılarak değerlendirilmiştir. Analizlerde betimleyici istatistiklerin, One-Way ANOVA, Tukey HSD testi ve Pearson Korelasyon analizlerinden faydalanılmıştır. Araştırma bulgularında öğrencilerin, benlik saygısı puanlarının yaş, sınıf, gelir düzeyi ve lisanslı spor yapma durumu açısından anlamlı farklılıklar gösterdiği (p<0.05), beden eğitimi ve spor dersine ilişkin tutum puanlarında ise cinsiyet ve lisanslı spor yapma durumu değişkenleri açısından anlamlı farklılıklar gösterdiği (p<0.05) belirlenmiştir. Ayrıca benlik saygıları ile beden eğitimi ve spor (BES) dersine ilişkin tutum puanları arasında pozitif yönde anlamlı bir ilişkinin olduğu görülmüştür. Sonuç olarak, fen lisesi öğrencilerinin demografik özelliklerine göre benlik saygısı düzeyleri ile BES dersine ilişkin tutumlarında pozitif yönlü anlamlı ilişkiler olduğu, benlik saygısı kavramının, beden eğitimi ve spor dersine ilişkin olumlu tutum geliştirmede önemli bir yordayıcı olduğu sonucuna ulaşılmıştır.
Changes in the macrobenthic infaunal community of the Southern California continental margin over five decades in relation to oceanographic factors
Authors: Gillett DJ , Weisberg SB , Alin SR , Cadien D , Velarde R , Barwick K , Larsen C , Latker A
Published: September 2023

Climate change has altered the physiochemical conditions of the coastal ocean but effects on infaunal communities have not been well assessed. Here, we used multivariate ordination to examine temporal patterns in benthic community composition from 4 southern California continental shelf monitoring programs that range in duration from 30 to 50 yr. Temporal changes were compared to variations in temperature, oxygen, and acidification using single-taxon random forest models. Species richness increased over time, coupled with a decline in overall abundance. Continental shelf macrobenthic communities from the 2010s comprised a broader array of feeding guilds and life history strategies than in the 1970s. Changing water temperature was associated with northward shifts in geographic distribution and increases in species abundance, while acidification was associated with southward shifts and declines in abundance of other species. Acidification was also associated with changes in depth distribution of benthic fauna, with shelled molluscs declining in abundance at depths most associated with increasing exposure to acidification. This broad-scale community-level analysis establishes causal hypotheses that set the stage for more targeted studies investigating shifts in abundance or distribution for taxa that appear to be responding to climate change-related disturbances.
Relationship between Physical Satisfaction and Depression in Nursing Students: Mediating Effect of Self-esteem
Authors:   The Korean Society of Culture and Convergence, Seo JiUn , Han Jeongwon
Published: September 2023

The purpose of this study is to verify the mediation effect of self-esteem in the relationship between physical satisfaction and depression of nursing college students. The 179 copies were analyzed by conducting a survey on physical satisfaction, depression, and self-esteem for nursing students at a university. Correlation analysis and hierarchical regression analysis were conducted to confirm the mediating effect of self-esteem. First, physical satisfaction and depression have a negative correlation, physical satisfaction and self-esteem have a positive correlation, and depression and self-esteem have a negative correlation. Second, self-esteem and depression showed a partial mediating effect in the relationship between physical satisfaction and depression. The significance of the results of this study is to provide basic data for effective intervention development to ensure positive physical satisfaction and emotions of nursing college students in the future.
Case Studies of Korean Language Classes Using Shadowing: Focus on Changes in Korean Language Speaking Efficacy of Myanmar Learners
Authors:   The Korean Society of Culture and Convergence, Yun Haesook , Kang Sosan
Published: September 2023

The purpose of this study is to examine a case of Korean language classes incorporating shadowing and verify its effectiveness. In this study, shadowing classes were conducted with Myanmar learners, and the effectiveness of shadowing classes was assessed by measuring learners' Korean language speaking efficacy before and after the classes. And learner satisfaction surveys and interviews were conducted to explore learners' perceptions. The results showed that Korean language speaking efficacy improved from 2.76 to 3.37 out of 5, indicating statistically significant improvement. This suggests that shadowing classes had a positive impact on Korean speaking efficacy. The learner satisfaction survey revealed a high average rating of 4.56 out of 5 for satisfaction with shadowing classes. The question regarding the level of interest in shadowing classes received an average rating of 5, indicating that the classes sparked learners' interest. In the learner interviews, participants recognized improvements in pronunciation, intonation, and speech rate through shadowing classes. They also reported increased confidence in speaking skills and expressed that it was beneficial for their professional life.