bluuebunny/crossref_metadata_2025 huggingface dataset:
Cost-effectiveness analysis of ultra-hypofractionated radiotherapy and conventionally fractionated radiotherapy for intermediate- to high-risk localized prostate cancer
Authors: He Jiaoxue , Wang Qingfeng , Hu Qiancheng , Li Changlin
Published: January 2023

Background

Radiotherapy is an effective curative treatment option for intermediate- to high-risk localized prostate cancer. According to the HYPO-RT-PC trial (ISRCTN45905321), there was no significant difference in 5 years of follow-up in terms of failure-free survival, overall survival, urinary toxicity, and bowel toxicity, while erectile function decreased between ultra-hypofractionated radiotherapy with conventionally fractionated radiotherapy, except that the incidence of urinary toxicity in ultra-hypofractionated radiotherapy was higher at 1 year of follow-up. We evaluated the cost-effectiveness of ultra-hypofractionated radiotherapy and conventionally fractionated radiotherapy for intermediate- to high-risk localized prostate cancer from the Chinese payer’s perspective.

Methods

We developed a Markov model with a 15-year time horizon to compare the cost and effectiveness of ultra-hypofractionated radiotherapy with those of conventionally fractionated radiotherapy for localized intermediate- to high-risk prostate cancer. The outcomes were measured in quality-adjusted life-years (QALYs), incremental cost-effectiveness ratio (ICER), and willingness-to-pay (WTP). Univariable and probability sensitivity analyses were performed to evaluate the robustness of the Markov model.

Results

Based on the Markov model, conventionally fractionated radiotherapy yielded 2.32 QALYs compared with 2.14 QALYs in ultra-hypofractionated radiotherapy in China. The cost of ultra-hypofractionated radiotherapy was found to be decreased by about 14% folds ($4,251.04) in comparison with that of conventionally fractionated radiotherapy. The ICER of conventionally fractionated radiotherapy versus that of ultra-hypofractionated radiotherapy was $23,616.89 per QALY in China. The failure-free survival with grade 2 or worse urinary toxicity and the discount rate per annum were the most sensitive parameters utilized in ultra-hypofractionated radiotherapy. The cost-effectiveness acceptability curve showed that conventionally fractionated radiotherapy had 57.7% probability of being cost-effective under the Chinese WTP threshold.

Conclusion

From the perspective of Chinese payers, ultra-hypofractionated radiotherapy was not a cost-effective strategy compared with conventionally fractionated radiotherapy for patients with localized intermediate- to high-risk prostate cancer. Nevertheless, reduction of the grade 2 or worse urinary toxicity of ultra-hypofractionated radiotherapy could alter the results.
Flat dose regimen of toripalimab based on model-informed drug development approach
Authors: Li Lili , Qu Jianye , Song Ming , Zhao Qun , Yang Yonghua , Tan Xi , Hu Yanyan , Li Jing , Lin Yunfei , Feng Hui , Yao Sheng , Keegan Patricia , Chen Meixia
Published: January 2023

Introduction: Flat dosing regimen has recently been approved for programmed death receptor-1 (PD-1) inhibitors including toripalimab, nivolumab and pembrolizumab. The objective of this study is to provide pharmacological evidence for a flat dosing regimen of toripalimab by assessing the efficacy and safety profile of a 240 mg Q3W flat dose relative to the currently approved 3 mg/kg Q2W.

Methods: A population pharmacokinetic (PopPK) model was established based on 1,014 evaluable patients in 13 clinical studies. The exposure-objective response rate (ORR, n = 234) and exposure-safety (n = 152) analyses were performed by logistic regression. Three safety endpoints including grade ≥ 3 adverse events (AEs), treatment-related grade ≥ 3 AEs, and AEs leading to study drug discontinuation were evaluated. Progression-free survival (PFS, n = 234) was evaluated using a Cox proportional hazard model with the Kaplan-Meier survival curve.

Results: The PK profiles of toripalimab are best described by a two-compartment model with time-varying clearance characterized by a sigmoidal maximum effect (Emax) function. Simulations for the first dose and steady-state exposures for the 240 mg Q3W dosing regimen were comparable to those for the 3 mg/kg Q2W dosing regimen with 95% exposure coverage ranging from 88% to 96%. The exposure-safety analysis showed that the probability of an adverse event occurring did not increase with increases in toripalimab exposure. A flat exposure-response relationship for ORR was identified. The Kaplan–Meier survival curve showed that exposure was a predictor for PFS; however, no difference in treatment benefit was demonstrated across exposure quantiles using a Cox proportional hazard model.

Discussion: This study revealed that toripalimab exposure of 240 mg Q3W dosing regimen was comparable to 3 mg/kg Q2W dosing regimen. The safety and efficacy E-R results of 240 mg Q3W is flat. Hence, the 240 mg Q3W dosing regimen is determined to be a preferred therapeutic dosage for toripalimab due to the convenience of flat dose.
Population genetics and plant growth experiments as prerequisite for conservation measures of the rare European aquatic plant Luronium natans (Alismataceae)
Authors: Makuch Weronika A. , Wanke Stefan , Ditsch Barbara , Richter Frank , Herklotz Veit , Ahlborn Julian , Ritz Christiane M.
Published: January 2023

Information provided by population genetic studies is often necessary to effectively protect endangered species. In general, such data is scarce for aquatic plants and this holds also for Luronium natans, an aquatic macrophyte endemic to northwestern and western Europe. It is threatened across its whole distribution range due to human influences, in particular due to eutrophication and intensive fish farming. In spite of habitat protection populations continue to decline and re-introductions are one possibility to prevent the species’ extinction. Therefore, insights in genetic diversity and relatedness of source populations is warranted.

Thus, we performed Amplified Fragment-Length Polymorphism (AFLP) on two large populations in Saxony, Germany (Großenhainer Pflege and Niederspree), complemented with numerous additional occurrences from Europe. In addition, we conducted experiments on plant growth to assess optimal conditions for ex-situ cultivation taking water temperature, water level and substrate into account.

We revealed considerably high levels of genetic diversity within populations (Shannon Indices ranged from 0.367 to 0.416) implying that populations are not restricted to clonal growth only but reproduce also by open-pollinated flowers. Remarkably, the two geographically close Saxon populations were genetically distant to each other but subpopulations within a locality were completely intermingled. Concerning optimal cultivation conditions, longest roots were obtained at temperatures >14°C and saturated, but not submerging water levels.

Thus, our findings advocate for a re-introduction scheme from nearby source populations and provide detailed information on successful ex-situ cultivation.
The Arabidopsis thaliana trehalose-6-phosphate phosphatase gene AtTPPI regulates primary root growth and lateral root elongation
Authors: Lin Qingfang , Gong Jiaxin , Zhang Zhiliang , Meng Zizi , Wang Jianyong , Wang Song , Sun Jing , Gu Xu , Jin Yuting , Wu Tong , yan Nuo , Wang Yuxin , Kai Lei , Jiang Jihong , Qi Shilian
Published: January 2023

Roots are the main organs through which plants absorb water and nutrients. As the key phytohormone involved in root growth, auxin functions in plant environmental responses by modulating auxin synthesis, distribution and polar transport. The Arabidopsis thaliana trehalose-6-phosphate phosphatase gene AtTPPI can improve root architecture, and tppi1 mutants have significantly shortened primary roots. However, the mechanism underlying the short roots of the tppi1 mutant and the upstream signaling pathway and downstream genes regulated by AtTPPI are unclear. Here, we demonstrated that the AtTPPI gene could promote auxin accumulation in AtTPPI-overexpressing plants. By comparing the transcriptomic data of tppi1 and wild-type roots, we found several upregulations of auxin-related genes, including GH3.3, GH3.9 and GH3.12, may play an important role in the AtTPPI gene-mediated auxin transport signaling pathway, ultimately leading to changes in auxin content and primary root length. Moreover, increased AtTPPI expression can regulate primary root growth and lateral root elongation under different concentration of nitrate conditions. Overall, constitutive expression of AtTPPI increased auxin contents and improved lateral root elongation, constituting a new method for improving the nitrogen utilization efficiency of plants.
Working during the COVID-19 pandemic: Demands, resources, and mental wellbeing
Authors: Scheel Tabea Eleonore , Bendixen Lydia , Procházka Jakub , Acquadro Maran Daniela
Published: January 2023

The aim of this study was to investigate the relationship between working conditions at the start of the COVID-19 pandemic (spring 2020) and employees’ mental wellbeing. According to the Job Demands-Resources (JD-R) model, work intensification, increased difficulty in accomplishing work tasks, heightened risk of infection by COVID-19, and increasingly working from home may detrimentally relate to irritation. However, personal and job resources (e.g., occupational self-efficacy, social support) may buffer. Data from 680 employees from four European countries were analyzed by means of path analyses and polynomial regression. Work intensification was significantly positively associated with cognitive and affective irritation; other job demands were not. However, working from home prior to as well as during the pandemic was related to higher cognitive irritation. None of the moderators was of meaningful significance. Reducing work intensification as well as enduring home office seems to be crucial for interventions.
Influence of biased feedback on performance in a Vernier discrimination task
Authors: Yang Chenfan , Xu Ziran , Zhong Yaoyao , Wang Tianze
Published: January 2023

The influence of feedback on performance is a topic of ongoing debate, with some previous studies finding it to be ineffective, while others have discovered that it can be helpful or harmful. One possible reason for these inconsistent results may be that feedback can create a conflict between a person's beliefs and the sensory information they receive. In the present study, we used a Vernier discrimination task to examine the influence of biased feedback on performance, as this type of feedback is most likely to create conflict. Biased feedback refers to feedback that does not align with the subjects' choices. The Vernier discrimination task is a type of psychophysical task that is often used to measure an individual's ability to perceive differences in the position or orientation of two visual stimuli. The task involves presenting two stimuli, one of which is slightly offset from the other, and asking the individual to determine the direction and magnitude of the offset. In Experiment 1, feedback was provided after each trial using large-offset verniers as guidance. The large-offset verniers always received correct feedback, but the small and medium-offset verniers might receive biased feedback. In Experiment 2, feedback was provided after each block of eight verniers. In Experiment 3, we removed the large offset vernier to investigate the influence of block feedback on the signal and noise. The results showed that the accuracy for the target vernier decreased due to biased feedback in both the trial feedback (Experiment 1) and the block feedback (Experiment 2). However, in Experiments 1 and 2, performance improved when feedback was absent. Moreover, if the difference between the two types of stimuli is great, the individual will engage in encoding learning rather than decision learning (Experiments 1 and 2). If the discrimination between the two types of stimuli is low, an individual's ability to discriminate noise is more vulnerable to the influence of biased feedback than the ability to discriminate the signal (Experiment 3). These results are discussed in relation to the mechanism of biased feedback, the process of encoding learning, the monitoring of internal feedback, and the generalization of false decisions.
The Effectiveness of Computer Aided Video Modeling in Teaching Basic Basketball Movements to Individuals with Down Syndrome
Authors: Aydogan Aslan , Demirok Mukaddes Sakalli
Published: January 2023

In this study, the effectiveness of the video modeling method in teaching basic basketball skills to students with Down syndrome was examined. Four students with Down syndrome, who were studying at the disability free living center in Dolayaba, participated in this study. The ages of the students diagnosed with Down syndrome were as follows: two of them were 13, the others were 14 and 16. In the study, the effectiveness of video modeling in teaching basic basketball skills was evaluated using the multiple probe model, one of the single-subject research methods. The experimental process of the study consisted of collecting baseline data, daily, conducting instructional sessions, maintenance and generalization stages. The findings of the study showed that video modeling was effective in teaching basic basketball skills to students with Down syndrome and that they maintained the skills in interpersonal and environmental differences after the end of the instruction. When the opinions of the basketball teacher and the students were evaluated, it was determined that the students’ self-confidence and peer relations were strengthened thanks to their active participation in the lessons. The students were not bored because they stated that they found the lessons interesting and fun.
A Planned Multidisciplinary Surgical Approach to Treat Primary Pelvic Malignancies
Authors: Sambri Andrea , Fiore Michele , Rottoli Matteo , Bianchi Giuseppe , Pignatti Marco , Bortoli Marta , Ercolino Amelio , Ancetti Stefano , Perrone Anna Myriam , De Iaco Pierandrea , Cipriani Riccardo , Brunocilla Eugenio , Donati Davide Maria , Gargiulo Mauro , Poggioli Gilberto , De Paolis Massimiliano
Published: January 2023

The pelvic anatomy poses great challenges to orthopedic surgeons. Sarcomas are often large in size and typically enclosed in the narrow confines of the pelvis with the close proximity of vital structures. The aim of this study is to report a systematic planned multidisciplinary surgical approach to treat pelvic sarcomas. Seventeen patients affected by bone and soft tissue sarcomas of the pelvis, treated using a planned multidisciplinary surgical approach, combining the expertise of orthopedic oncology and other surgeons (colleagues from urology, vascular surgery, abdominal surgery, gynecology and plastic surgery), were included. Seven patients were treated with hindquarter amputation; 10 patients underwent excision of the tumor. Reconstruction of bone defects was conducted in six patients with a custom-made 3D-printed pelvic prosthesis. Thirteen patients experienced at least one complication. Well-organized multidisciplinary collaborations between each subspecialty are the cornerstone for the management of patients affected by pelvic sarcomas, which should be conducted in specialized centers. A multidisciplinary surgical approach is of paramount importance in order to obtain the best successful surgical results and adequate margins for achieving acceptable outcomes.
An Exceptional Cause of Increased 18F-Fluorodeoxyglucose Uptake on PET/CT in a Thyroid Nodule
Authors: Manta Ringo , Muteganya Raoul , Beun Abraham J. , Fallas Jennifer , Poppe Kris G.
Published: January 2023

A 41-year-old female underwent a cervical spine CT for the workup of posterior neck pain irradiating to the shoulders for several months. An incidental thyroid nodule was found and classified as Bethesda III on the Fine-needle aspiration cytology (FNAC) results. Three months later, the patient developed mild shortness of breath, dry cough, and fever. Chest X-ray revealed a mild enlargement in the bilateral hilar regions. CT showed mediastinal and bilateral hilar enlarged lymph nodes and pulmonary micronodules. The workup was further completed with a 18F-FDG PET/CT, showing intense FDG uptake in the mediastinal and bilateral hilar lymph nodes and increased uptake in the thyroid nodule. Endobronchial Ultrasound-guided Transbronchial needle aspiration (EBUS-TBNA) of a left hilar lymph node showed epithelioid non-necrotizing granulomas. Because of the FNAC results, size of the nodule and tracheal shift, thyroid lobectomy was performed one month later. Histopathological results also revealed multiple non-necrotizing epithelioid granulomas, suggesting systemic sarcoidosis with involvement of the thyroid. To our knowledge, this is the first report of thyroid sarcoidosis detected on 18F-FDG PET/CT. Although an increased FDG uptake in a thyroid nodule is usually suggestive of thyroid malignancy, toxic nodule, or follicular hyperplasia, our case report shows that it could also suggest thyroid sarcoidosis.
Heteroatom-Doped Nickel Sulfide for Efficient Electrochemical Oxygen Evolution Reaction
Authors: Zheng Xingqun , Zhang Ling , He Wei , Li Li , Lu Shun
Published: January 2023

Heteroatom doping is an effective strategy to regulate electrocatalysts for the oxygen evolution reaction (OER). Nonmetal heteroatoms can effectively engineer geometric and electronic structures and activating surface sites of catalysts due to their unique radius and the electronegativity of nonmetal atoms. Hence, the surface geometric and electronic structure and activity of nonmetal atoms (X, X = B, C, N, O, P)-doped Ni3S2 (X-Ni3S2) were studied to screen high-performance Ni3S2-based OER electrocatalysts through density functional theory calculation. Theoretical results demonstrated that dopants in X-Ni3S2 can alter bond length and charge of surface, modify active sites for intermediates adsorption, and adjust the theoretical overpotential. Among all dopants, C can effectively modulate surface structure, activate surface sites, weaken the adsorption of key intermediates, decrease theoretical overpotential, and enable C-Ni3S2 with the best theoretical OER activity among all X-Ni3S2 with the lowest theoretical overpotential (0.46 eV). Further experimental results verified that the synthesized C-Ni3S2 performed an improved OER activity in the alkaline condition with a considerably enhanced overpotential of 261 mV at 10 mA cm−2 as well as a Tafel slope of 95 mV dec−1 compared to pristine Ni3S2.
Intelligent Identification Method for Drilling Conditions Based on Stacking Model Fusion
Authors: Gao Yonghai , Yu Xin , Su Yufa , Yin Zhiming , Wang Xuerui , Li Shaoqiang
Published: January 2023

Due to the complex and changing drilling conditions and the large scale of logging data, it is extremely difficult to process the data in real time and identify dangerous working conditions. Based on the multi-classification intelligent algorithm of Stacking model fusion, the 24 h actual working conditions of an XX well are classified and identified. The drilling conditions are divided into standpipe connection, tripping out, tripping in, Reaming, back Reaming, circulation, drilling, and other conditions. In the Stacking fusion model, the accuracy of the integrated model and the base learner is compared, and the confusion matrix of the drilling multi-condition recognition results is output, which verifies the effectiveness of the Stacking model fusion. Based on the variation in the parameter characteristics of different working conditions, a real-time working condition recognition diagram of the classification results is drawn, and the adaptation rules of the Stacking fusion model under different working conditions are summarized. The stacking model fusion method has a good recognition effect under the standpipe connection condition, tripping in condition, and drilling condition. These three conditions’ accuracy, recall rate, and F1 value are all above 90%. The stacking model fusion method has a relatively poor recognition effect on ‘other conditions‘, and the accuracy rate, recall rate, and F1 value reach less than 80%.
Overview of Common Thermophysical Property Modelling Approaches for Cryogenic Fluid Simulations at Supercritical Conditions
Authors: Madana Gopal Jaya Vignesh , Morgan Robert , De Sercey Guillaume , Vogiatzaki Konstantina
Published: January 2023

Computational Fluid Dynamics (CFD) frameworks of supercritical cryogenic fluids need to employ Real Fluid models such as cubic Equations of State (EoS) to account for thermal and inertial driven mechanisms of fluid evolution and disintegration. Accurate estimation of the non-linear variation in density, thermodynamic and transport properties is required to computationally replicate the relevant thermo and fluid dynamics involved. This article reviews the availability, performance and the implementation of common Real Fluid EoS and data-based models in CFD studies of supercritical cryogenic fluids. A systematic analysis of supercritical cryogenic fluid (N2, O2 and CH4) thermophysical property predictions by cubic (PR and SRK) and non-cubic (SBWR) Real Fluid EoS, along with Chung’s model, reveal that: (a) SRK EoS is much more accurate than PR at low temperatures of liquid phase, whereas PR is more accurate at the pseudoboiling region and (b) SBWR EoS is more accurate than PR and SRK despite requiring the same input parameters; however, it is limited by the complexity in thermodynamic property estimation. Alternative data-based models, such as tabulation and polynomial methods, have also been shown to be reliably employed in CFD. At the end, a brief discussion on the thermophysical modelling of cryogenic fluids affected by quantum effects is included, in which the unsuitability of the common real fluid EoS models for the liquid phase of such fluids is presented.
Application of the Gradient-Based Metaheuristic Optimizerto Solve the Optimal Conductor Selection Problemin Three-Phase Asymmetric Distribution Networks
Authors: Pradilla-Rozo Julián David , Vega-Forero Julián Alejandro , Montoya Oscar Danilo
Published: January 2023

This study addresses the problem of selecting the conductor sizes for medium-voltage distribution networks with radial configurations. The optimization model that represents this problem is part of the mixed-integer non-linear programming (MINLP) models, in which a power flow must be solved for each possible combination of conductor sizes. The main objective of this optimization problem is to find the best set of conductor sizes that minimize an economic objective function composed of the total costs of conducting materials added with the expected annual costs of the energy losses by proposing a new hybrid optimization methodology from the family of combinatorial optimization methods. To solve the MINLP model, a master–slave optimization method based on the modified version of the gradient-based metaheuristic optimizer (MGbMO) combined with the successive approximation power flow method for unbalanced distribution networks is presented. The MGbMO defines the set of conductor sizes assignable for each distribution line using an integer codification. The slave stage (three-phase power flow) quantifies the total power losses and their expected annual operating costs. Numerical results in the IEEE 8-, 27-, and 85-bus grids demonstrate the effectiveness of the proposed master–slave optimizer when compared with multiple combinatorial optimization methods (vortex search algorithm, the Newton-metaheuristic optimizer, the traditional and Chu and Beasley genetic algorithms, and the tabu search approaches). Two scenarios regarding the demand behavior were analyzed for the IEEE 8- and 27-bus grids: a peak load operation was considered, and, for the IEEE 85-bus grid, the daily demand behavior, including the presence of renewable generators, was considered. The 85-bus grid allowed showing that the most realistic operative scenario for selecting conductors is the case where a demand curve is implemented since reductions over 40% in the annual investment and operating costs were found when compared to the peak load operating condition. All numerical validations were performed in MATLAB software.
Semitransparent Perovskite Solar Cells for Building Integrated Photovoltaics: Recent Advances
Authors: Srivishnu Kalavala Shivaprakash , Markapudi Prasutha Rani , Sundaram Senthilarasu , Giribabu Lingamallu
Published: January 2023

Perovskite solar cells technology is one of the most advanced and fascinating technologies in the field of photovoltaics due to its low-cost processing and delivering efficient power conversion efficiencies. The ability to become transparent is another prolific property of the perovskite solar cells, which this property has been tried to be exploited in recent times by researchers to serve the environmental and energy needs of human beings. Using this transparency and enabling semitransparent perovskite solar cells (ST-PSCs) to be placed on the windows and rooftops of buildings will reduce room temperature along with fulfilling certain requirements of power needs. This review pays attention to the recent developments in the semitransparent perovskite solar cells from the perspective of the structure of ST PSCs, electrodes and others.
Energy-Aware Scheduling for High-Performance Computing Systems: A Survey
Authors: Kocot Bartłomiej , Czarnul Paweł , Proficz Jerzy
Published: January 2023

High-performance computing (HPC), according to its name, is traditionally oriented toward performance, especially the execution time and scalability of the computations. However, due to the high cost and environmental issues, energy consumption has already become a very important factor that needs to be considered. The paper presents a survey of energy-aware scheduling methods used in a modern HPC environment, starting with the problem definition, tackling various goals set up for this challenge, including a bi-objective approach, power and energy constraints, and a pure energy solution, as well as metrics related to the subject. Then, considered types of HPC systems and related energy-saving mechanisms are described, from multicore-processors/graphical processing units (GPU) to more complex solutions, such as compute clusters supporting dynamic voltage and frequency scaling (DVFS), power capping, and other functionalities. The main section presents a collection of carefully selected algorithms, classified by the programming method, e.g., machine learning or fuzzy logic. Moreover, other surveys published on this subject are summarized and commented on, and finally, an overview of the current state-of-the-art with open problems and further research areas is presented.
Single-Phase Grid-Forming Strategy with Power Decoupling Implementation for Electrolytic-Capacitor-Free EV Smart Battery Charger
Authors: Sal y Rosas Damián , Zarate Alvaro
Published: January 2023

Smart Battery Chargers (SBCs) implementing grid-forming (GFM) control strategies are a promising solution to provide voltage and frequency support, increasing the grid reliability. Typically, GFM studies consider inverters with high DC-link capacitance. Therefore, there is a research gap in two-stage DC-AC converters with small DC-link capacitance implementing GFM strategies. This article proposes a novel approach to implement a GFM control strategy along with active power decoupling (APD) in an isolated, single-phase, electrolytic-capacitor-free two-stage DC-AC structure. The structure is composed of a voltage source inverter (VSI), DC-linked by film capacitors, with a dual-active-bridge series-resonant (DABSR) DC-DC converter. High DC-link ripple is allowed and managed by the APD. Hence, electrolytic capacitors are avoided, increasing the converter lifetime. In the proposed approach, the VSI implements the GFM strategy, operating in the four quadrants of the active and reactive power plane. However, the DABSR allows galvanic isolation, average DC-link voltage control, and suppression of the low-frequency ripple on the battery current, minimizing the impact in the battery lifetime. Design criteria are given for the DC-link voltage controller, active-reactive power controllers, inner inverter controllers, and APD technique. The control strategy is validated for vehicle-to-grid and stand-alone vehicle-to-home applications, using hardware-in-the-loop for a 2kW test setup.
Nitrogen Oxides and Ammonia Removal Analysis Based on Three-Dimensional Ammonia-Diesel Dual Fuel Engine Coupled with One-Dimensional SCR Model
Authors: Sun Xingyu , Li Mengjia , Li Jincheng , Duan Xiongbo , Wang Can , Luo Weifan , Liu Haifeng , Liu Jingping
Published: January 2023

Ammonia, as an alternative fuel for internal combustion engines, can achieve nearly zero carbon emissions. Although the development of the pure ammonia engine is limited by its poor combustion characteristics, ammonia–hydrocarbon mixed combustion can effectively improve the combustion of ammonia fuel. With the increase in the ammonia fuel proportion in the fuel mixture, a large number of nitrogen oxides (NOX) and unburned ammonia may be discharged, which have a poor impact on the environment. In this study, the performance of selective catalytic reduction (SCR) aftertreatment technology in reducing NOX and ammonia emissions from ammonia–diesel dual-fuel engines was investigated using simulation. A good cross-dimensional model was established under the coupling effect, though the effect of a single-dimensional model could not be presented. The results show that when the exhaust gas in the engine cylinder is directly introduced into the SCR without additional reducing agents such as urea, unburned ammonia flowing into SCR model is in excess, and there will be only ammonia at the outlet; however, if the unburned ammonia fed into the SCR model is insufficient to reduce NO, the ammonia concentration at the outlet will be 0. NOX can be 100% effectively reduced to N2 under most engine conditions; thus, unburned ammonia in exhaust plays a role in reducing NOX emissions from ammonia–diesel dual-fuel engines. However, when the concentration of unburned ammonia in the exhaust gas of an ammonia–diesel dual-fuel engine is large, its ammonia emissions are still high even after the SCR. In addition, the concentrations of N2O after SCR do not decrease, but increase by 50.64 in some conditions, the main reason for which is that by the action of the SCR catalyst, NO2 is partially converted into N2O, resulting in an increase in its concentration at the SCR outlet. Adding excessive air or oxygen into the SCR aftertreatment model can not only significantly reduce the ammonia concentration at the outlet of the model without affecting the NOX conversion efficiency of SCR, but inhibit N2O production to some extent at the outlet, thus reducing the unburned ammonia and NOX emissions in the tail gas of ammonia–diesel dual-fuel engines at the same time without the urea injection. Therefore, this study can provide theoretical guidance for the design of ammonia and its mixed-fuel engine aftertreatment device, and provide technical support for reducing NOX emissions of ammonia and its mixed fuel engines.
Electricity Supply Regulations in South America: A Review of Regulatory Aspects
Authors: Delavechia Robson Porsch , Ferraz Bibiana P. , Weiand Raul Scapini , Silveira Leonardo , Ramos Maicon Jaderson Silveira , dos Santos Laura Lisiane Callai , Bernardon Daniel Pinheiro , Garcia Rui Anderson Ferrarezi
Published: January 2023

The quality of electricity is one of the most discussed issues in the regulatory context, structured by guidelines that allow the assessment of efficiency in electricity supply. Regarding electricity distribution systems, it is essential to highlight the aspects associated with the definition of continuity indicators to measure the service provided by the utilities. The parameters used to calculate the indicators are set by specific agencies in each country based on studies and their characteristics. With the growth in demand for electricity, debates associated with reducing greenhouse gas emissions in the atmosphere, and the increase in Distributed Energy Resources (DERs) connected to the grid, a new trend related to the energy supply is verified. Given these new scenarios, this paper presents a literature review in the regulatory field of existing distribution systems in South American countries. The research proposes to analyze, compare, and expose the current models to evaluate their methods and indicators, including a complete case study in Brazil. This paper seeks to illustrate and point out perspectives, challenges, and future perspectives through the collected and analyzed data.
A Review on Numerical Simulation of Hydrogen Production from Ammonia Decomposition
Authors: Ao Rui , Lu Ruihua , Leng Guanghui , Zhu Youran , Yan Fuwu , Yu Qinghua
Published: January 2023

Ammonia (NH3) is regarded as a promising medium of hydrogen storage, due to its large hydrogen storage density, decent performance on safety and moderate storage conditions. On the user side, NH3 is generally required to decompose into hydrogen for utilization in fuel cells, and therefore it is vital for the NH3-based hydrogen storage technology development to study NH3 decomposition processes and improve the decomposition efficiency. Numerical simulation has become a powerful tool for analyzing the NH3 decomposition processes since it can provide a revealing insight into the heat and mass transfer phenomena and substantial guidance on further improving the decomposition efficiency. This paper reviews the numerical simulations of NH3 decomposition in various application scenarios, including NH3 decomposition in microreactors, coupled combustion chemical reactors, solid oxide fuel cells, and membrane reactors. The models of NH3 decomposition reactions in various scenarios and the heat and mass transport in the reactor are elaborated. The effects of reactor structure and operating conditions on the performance of NH3 decomposition reactor are analyzed. It can be found that NH3 decomposition in microchannel reactors is not limited by heat and mass transfer, and NH3 conversion can be improved by using membrane reactors under the same conditions. Finally, research prospects and opportunities are proposed in terms of model development and reactor performance improvement for NH3 decomposition.
The Association between Non-Alcoholic Fatty Liver Disease and Dynapenia in Men Diagnosed with Type 2 Diabetes Mellitus
Authors: Bulur Atilla , Sivritepe Rıdvan
Published: January 2023

Background: Dynapenia and non-alcoholic fatty liver disease (NAFLD) are common, especially in the middle and advanced-age diabetic male population. We aimed to examine the clinical features, NAFLD severity, and parameters associated with the presence of dynapenia in type 2 diabetes mellitus (T2DM) cases. Material and Methods: One hundred thirty-five male patients diagnosed with T2DM between 45 and 65 years of age were included. Patients were staged by ultrasonography according to NAFLD status. Results: There were significant differences in muscle strength, upper arm circumference, calf circumference, and up-and-go test scores between the mild-moderate-severe and non-NAFLD groups (p < 0.001 for all). The frequency of dynapenia was lower, and arm and calf circumferences were higher in patients without NAFLD. The muscle strength, upper arm circumference, calf circumference, and up-and-go test scores were significantly lower in the dynapenic group compared to the non-dynapenic group (p < 0.005 for all). The prevalence of dynapenia increased along with the increase in NAFLD stages (p < 0.001). Conclusions: We detected a significant association between NAFLD and dynapenia in middle-aged men with T2DM. As muscle strength decreases, the amount of fat in the liver increases, and as the fat in the liver increases, muscle strength decreases.
The Effect of a Single Bout of Chinese Archery on Core Executive Functions in Preadolescent Children in Shanghai
Authors: Liu Jianjun , Taneepanichskul Surasak , Zhang Bo , Xenos Peter
Published: January 2023

Background: Recent literature has demonstrated that acute physical activity benefits the transfer of executive functions. However, further studies indicated the type of variability in the effect of physical activity on executive functions. Therefore, this study initially explored the effect of a single bout of Chinese archery on subdomains of core EFs in preadolescent children; Method: Eligible participants were allocated either an intervention group (n = 36) or a control group (n = 36). The subjects in the intervention group received a 45-min Chinese archery session. The primary outcomes were the performance of core EFs (inhibition control, working memory, and cognitive flexibility) in preadolescent children, assessed with psychological paradigms (Fish Flanker Task, N-Back Task, and DCCS (Border version), respectively). Paired t-test and ANCOVA were used to analyze the mean difference in the performance of core EFs within and between subjects, respectively; Results: Considering reaction time and accuracy, we explored the impressive performance in three cognitive tasks with acute Chinese archery; Conclusion: The finding suggests that a single bout of Chinese archery benefited three subdomains of core EFs in healthy preadolescent children.
Exploring the Public Health of Travel Behaviors in High-Speed Railway Environment during the COVID-19 Pandemic from the Perspective of Trip Chain: A Case Study of Beijing–Tianjin–Hebei Urban Agglomeration, China
Authors: Yu Shuai , Li Bin , Liu Dongmei
Published: January 2023

The outbreak and spreading of COVID-19 since early 2020 have dramatically impacted public health and the travel environment. However, most of the studies are devoted to travel behavior from the macro perspective. Meanwhile, few researchers pay attention to intercity travel behavior. Thus, this study explores the changes in the travel behavior of intercity high-speed railway travelers during the COVID-19 pandemic from the perspective of the individual. Using the smartphone data, this study first extracts the trip chains by proposing a novel method including three steps. The trip chain can describe the whole process of traveling, including individual characteristics, travel time, travel distance, travel mode, etc. Then, a Multinomial Logit model is applied to analyze the trip chains which verified the validity by using studentized residual error. The study finds that intercity travel behavior has changed in gender, age, travel mode choice, and travel purpose by comparing the trip chains between May 2019 and May 2021 in the Beijing–Tianjin–Hebei urban agglomeration. The method proposed in this study can be used to assess the impact of any long-term emergency on individual travel behavior. The findings proposed in this study are expected to guide public health management and travel environment improvement under the situation of normalized COVID-19 prevention and safety control.
Research on the Duality of China’s Marine Fishery Carbon Emissions and Its Coordination with Economic Development
Authors: Xiong Huanhuan , Wang Xuejing , Hu Xinrui
Published: January 2023

Through the Tapio model, this paper measures the “decoupling and coupling” relationship between carbon emissions, carbon sinks, and economic growth of marine fisheries in nine coastal provinces of China in 2009–2019, objectively evaluates the economic benefits of carbon emissions and low-carbon development potential, and then discusses the economic development models of marine fisheries in detail. The results showed that the total carbon sink and carbon emission of China’s marine fisheries are increasing. Guangdong is dominated by “double low” economic benefits and low-carbon potential, and “double high” provinces have better resource endowment conditions; China’s marine fishery economic development is still dominated by conventional types. To further promote the sustainable development of China’s marine fisheries, all provinces should define the development orientation of marine fisheries, improve the production methods of marine fisheries according to local conditions, and adjust the industrial structure of marine fisheries in a timely manner, to achieve the low-carbon fishery goal of reducing carbon emissions and growing the economy.
A Study on the Structural Relationships between COVID-19 Coping Strategies, Positive Expectations, and the Behavioral Intentions of Various Tourism-Related Behaviors
Authors: Zhang Mengen , Song HakJun
Published: January 2023

The purpose of this study was to investigate the impact of coping strategies, attitudes, and positive anticipated emotions on the positive expectations and behavioral intentions of Korean tourists during the COVID-19 pandemic. An integrated model was proposed and tested, and the results indicate that effective coping strategies, attitudes, and positive anticipated emotions have a positive effect on the positive expectations of tourism during the pandemic, which in turn positively influences behavioral intentions. Practical suggestions were also provided based on the findings. This research has implications for understanding the ways in which individuals cope with and adapt to travel during times of crisis, and for identifying strategies that may facilitate positive expectations and behavioral intentions in the tourism industry.
Attracting, Recruiting, and Retaining Medical Workforce: A Case Study in a Remote Province of Indonesia
Authors: Noya Farah C. , Carr Sandra E. , Thompson Sandra C.
Published: January 2023

Indonesia, one of the Asia Pacific low-and middle-income countries (LMICs), has suffered from a chronic medical workforce shortage. However, there are limited published studies describing the approaches implemented by the Indonesian government regarding the recruitment and retention of the medical workforce. This case study aimed to understand the current practices for recruitment and retention of the medical workforce in Indonesian rural and remote provinces. We conducted a case study of the Maluku Province of Indonesia with a document analysis and key informant interviews with officials responsible for medical workforce recruitment and retention. We used the World Health Organization’s (WHO) guidelines as an analytical matrix to examine the recruitment and retention practices under the four domains of (i) educational, (ii) regulatory, (iii) financial, and (iv) professional and personal development and classified them into either University/Medical School level or Government/Non-government level. Our findings suggest that Indonesia implemented most of the WHO-recommended medical workforce recruitment and retention strategies. However, implementation is still problematic; hence, the aim of establishing an adequate, sustainable medical workforce has not been reached. Nationwide government intervention in educational aspects is important to magnify the impact of regional medical school initiatives. Relevant programmes must be re-evaluated and re-enforced concerning significance, comprehensiveness, and effectiveness for a sustainable rural and remote medical workforce.
Longitudinal Relationship between Bullying Victimization and Non-Suicidal Self-Injury among Chinese Adolescents: The Buffering Roles of Gratitude and Parental Autonomy Support
Authors: Wu Nini , Mo Jianhong , Wen Anluan , Ou Haoer , Gu Weixin , Qiu Yunqing , Yuan Lixin , Lan Xiaoyu
Published: January 2023

Drawing on the resilience-oriented socioecological framework, the current study contributes to scarce scholarship by exploring intrapersonal (i.e., gratitude) and interpersonal (i.e., parental autonomy support) factors in the longitudinal association between bullying victimization and adolescent non-suicidal self-injury (NSSI). Participants were 238 Chinese adolescents (Mage at Time 1 (T1) = 13.45 years; 106 girls and 132 boys) based on a two-wave prospective design with data spanning one year. At T1, adolescents self-rated all study variables, and at Time 2 (T2), youth again reported their NSSI. The results showed a significant main effect (b = 0.12, SE = 0.05, p = 0.04), indicating that bullying victimization was positively related to T2 NSSI one year later, even controlling for T1 NSSI. Moderation analyses further indicated that parental autonomy support buffered against the positive association between bullying victimization and T2 NSSI, but only when adolescents experienced lower levels of gratitude. Specifically, for adolescents with lower levels of gratitude, high levels of parental autonomy support, in a compensatory way, prevented adolescents from NSSI after victimization occurred (b = −0.03, SE = 0.09, p = 0.78); by contrast, for those with higher levels of gratitude, bullying victimization was not significantly related to T2 NSSI, regardless of the levels of parental autonomy support (b = 0.07, SE = 0.04, p = 0.59 for higher parental autonomy support; b = 0.01, SE = 0.07, p = 0.93 for lower parental autonomy support). These findings suggest that gratitude and parental autonomy support, manifesting in a compensatory interaction pattern, could serve as targeted agents for breaking the vicious linkage between bullying victimization and NSSI.
The Institutional Positioning of Environmental Tort Remedy in China: Executive-Led or Judicial-Led?
Authors: Sang Tian , Zhang Lijun
Published: January 2023

There are two options for environmental tort remedy in China: resorting to environmental administration or environmental justice, with an ongoing debate over which of the two should lead. Firstly, it compares the structure of China’s environmental tort remedy system and the two types of power: administrative power and judicial power, concluding that administrative power is dominant. Then, it argues for the indispensability of judicial power, attempts to find a clear boundary between the two sides, and justifies their mutual division of labor and collaboration. Through sufficient demonstration, it clarifies why the dominant position of environmental administrative power must be guaranteed. Then, it summarizes the experience of other countries and the practice of environmental protection in China; and provides three innovative paths of the future environmental rights remedy system. These three aspects are setting up a review procedure for administrative priority judgment before filing an environmental lawsuit, establishing the independent position of experts in environmental litigation, advocating a risk communication mechanism other than litigation, and providing a richer institutional guarantee for the relief of environmental rights.
Enhancing the Biological Oxidation of H2S in a Sewer Pipe with Highly Conductive Concrete and Electricity-Producing Bacteria
Authors: Vo Huy Thanh , Imai Tsuyoshi , Fukushima Masato , Promnuan Kanathip , Suzuki Tasuma , Sakuma Hiraku , Hitomi Takashi , Hung Yung-Tse
Published: January 2023

Hydrogen sulfide (H2S) generated in sewer systems is problematic to public health and the environment, owing to its corrosive consequences, odor concerns, and poison control issues. In a previous work, conductive concrete, based on amorphous carbon with a mechanism that operates as a microbial fuel cell was investigated. The objective of the present study is to develop additional materials for highly conductive concrete, to mitigate the concentration of H2S in sewer pipes. Adsorption experiments were conducted to elucidate the role of the H2S reduction. Additionally, electricity-producing bacteria (EPB), isolated from a municipal wastewater treatment plant, were inoculated to improve the H2S reduction. The experimental results showed that inoculation with EPB could decrease the concentration of H2S, indicating that H2S was biologically oxidized by EPB. Several types of new materials containing acetylene black, or magnetite were discovered for use as conductive concrete, and their abilities to enhance the biological oxidation of H2S were evaluated. These conductive concretes were more effective than the commercial conductive concrete, based on amorphous carbon, in decreasing the H2S concentration in sewer pipes.