bluuebunny/crossref_metadata_2025 huggingface dataset:
Cadmium induces microcytosis, hypochromicity, and anisocytosis without anaemia in hypertensive rats
Authors: McCalla Garsha , Brown Paul D. , Nwokocha Chukwuemeka
Published: August 2023

Background and Aim: Dietary cadmium (Cd2+) intake is implicated in the pathogenesis of hypertension and anaemia, but there is a paucity of information on the haematological changes in hypertensive conditions. This study, therefore, aims to evaluate the effects of Cd2+ on blood pressure (BP) and haematological indices in the Sprague-Dawley rat model.
Method: Three cohorts (n=10 each) of control and Cd2+-fed male Sprague-Dawley rats were selected. Cd2+-exposed rats received 2.5 or 5 mg/kg b.w. cadmium chloride via gavage thrice- weekly for eight weeks, while control animals received tap water. BP and flow were measured non-invasively from rat tails twice-weekly using a CODA machine, while weights were measured thrice-weekly. Haematological indices were assessed using the Cell-Dyn Emerald Haematology Analyzer (Abbott Diagnostics, IL, USA). Data were reported as mean ± SEM, and statistically analyzed using One-Way Analysis of Variance. Bonferroni post hoc test was used for multiple comparisons.
Results: Cd2+-exposure induced hypertension by significantly (p<0.05) elevating systolic, diastolic, and mean arterial BPs, pulse pressure, and heart rate (HR), and increased (p<0.05) blood flow. Mean cell volume (MCV) and haemoglobin (MCH) were significantly (p<0.05) reduced, and red cell distribution width (RDW) significantly (p<0.01) increased by exposure to 5 mg/kg b.w. Cd2+. Haemoglobin concentration (MCHC), haematocrit, haemoglobin, red blood cell, platelet, mean platelet volume, and white blood cell counts were unaffected by Cd2+-exposure.
Conclusion: Cd2+ induced hypertension, hypochromicity, and anisocytosis without anaemia, which may be precursor to microcytic anaemia and coronary artery disease. This study is important in Cd2+-exposed environments and warrants further investigations. Keywords: Cadmium; Hypertension; Microcytosis; Hypochromic anaemia; Anisocytosis
Enhanced bioethanol production in a microbial electrolysis cell by evolved Escherichia coli LGE2-H
Authors: Wang Cong , Chang Dongdong , Zhang Qi , Yu Zhisheng
Published: August 2023

Lignocellulose pretreated by pyrolysis can be transformed into clean energy (such as bioethanol) via microbial fermentation, which is significant for waste recycling, environmental protection, and energy security. However, acids, aldehydes, and phenols present in the bio-oil exert inhibitory effects on microorganisms, which challenges the downstream utilization and conversion of lignocellulosic pyrolysate. In this study, we constructed a microbial electrolysis cell system for bio-oil detoxification and efficient ethanol production (C2H5O) using evolved Escherichia coli. In the bio-oil media with electricity, E. coli-H exhibited significant levoglucosan consumption and ethanol production abilities compared to the control. Finally, 0.54 g ethanol/g levoglucosan was produced by E. coli-H in the undetoxified bio-oil media with 1.0%(w/v) levoglucosan, reaching 95% of the theoretical yield. This design aimed to solve bioethanol production and utilization challenges, as evident in related studies. This research provides a practical method for bioethanol production from lignocellulosic substrates and a scientific basis and technical demonstration for its industrialized application.
Optimization on Conharmonic and Conformal Curvature tensors in Einstein Field equations
Authors: Negi U. S. , Bhandari Sulochana
Published: August 2023

Ahsan (2005) has studied the geometrical symmetry of spacetime of general relativity. Also, Blair et. al. (2005) has premeditated concircular curvature tensor of a contact metric manifold. After that, Negi and Su-lochana (2021) calculated the conformal Symmetric Tensor of Kaehlerian Manifolds. In the present paper, the author obtained optimization on Con-harmonic and Conformal Curvature tensor in Einstein eld equations and variance-free conharmonic and conformal curvature tensor in space times. We used Friedmann-Robertson-Walker model for conformal curvature ten-sor.
MSC2020:53A20;53C80;53C50;53C18;53C25:
Prevalence and associated factors of anemia among people with cancer in ACSH, Tigray, Ethiopia
Authors: Woldemariam Abraha-G , Tsehaye Asgele , Mokonen Wendyefraw , Zeru Mebratom , Hagos Abel , Tsegay Gebriela , Birhane Yemane , Teklu Guesh
Published: August 2023

Background: anemia is becoming a public health problem particularly among people suffering from different types of cancer.
Objective: the aim of this study was to assess the prevalence and associated factors of anemia among people with cancer.
Methods: an institution based cross-sectional study was conducted from January to June 2020 in ACSH, Tigray, Ethiopia. Medical records were systematically reviewed to get demographic and clinical characteristics of 72 study subjects. Data were entered to SPSSv25 and descriptive analysis, logistic regression, independent sample T test and ANOVA were used for analysis.
Results: about 45.8% of study subjects with different types of cancer were found to have anemia. Unemployment (OR=2.167; 95%CI: 1.093, 4.294; p=0.027), rural residence (OR = 3.750; 95%CI: 1.245, 11.299; p= 0.019), advanced stages of cancer (OR = 10.771; 95%CI: 3.580, 32.405; p= 0.000), duration of cancer (OR=3.542; 95%CI: 1.289, 9.728; p=0.014) and higher (5-8) cycles of chemotherapy (OR = 3.000; 95%CI: 1.090, 8.254; p=0.033) were variables found to have statistically significant association with anemia.
Conclusion: anemia is a common complication in patients with different types of cancer. Occupation, residence, duration of cancer, stage of caner, chemotherapy, and cycles of chemotherapy significantly increased the prevalence of anemia in cancer patients.
Conformational Isomerization as a Key Selectivity-Determining Step
Authors: Kochi Takuya , Muto Kazuma , Hatanaka Miho , Kakiuchi Fumitoshi
Published: August 2023

Organic reactions take place in one or more elementary processes, and their product selectivity is determined by which elementary processes are involved in a reaction and how they occur. Among the elementary processes, bond-forming and cleaving processes are typically the only steps drawn in the proposed organic reaction mechanisms1and are generally considered to be more important than other processes such as conformational isomerization, which have rarely been recognized as key steps such as selectivity-determining steps. We report herein on an example where a conformational isomerization process, propeller-like alkene rotation,2,3is considered to determine the selectivity over the reaction pathways in a catalytic reaction. The transition state with the highest energy barrier in some palladium chain walking events was indicated by DFT calculations to correspond to alkene rotation in an alkene hydride palladium species, rather than bond-cleaving b-hydride elimination or bond-forming migratory insertion, even when there is only one transition state between an alkyl complex and an alkene hydride complex. It was also suggested both theoretically and experimentally that the chain walking over internal carbons in alkyl chains proceeds via cis alkene intermediates, rather than thermodynamically more stable trans alkene intermediates, due to their relative ease of undergoing alkene rotation.
Simultaneous single-cell three-dimensional genome and gene expression profiling Uncovers Dynamic Enhancer Connectivity Underlying Olfactory Receptor Choice
Authors: Xie Xiaoliang , Wu Honggui , Zhang Jiankun , Jian Fanchong , Chen Jinxin , Zheng Yinghui , Tan Longzhi
Published: August 2023

The simultaneous measurement of three-dimensional (3D) genome structure and gene expression of individual cells is critical for understanding genome’s structure–function relation, yet is extremely challenging for existing methods. Here we present Linking mRNA to Chromatin Architecture (LiMCA), which jointly profiles 3D genome and transcriptome with exceptional sensitivity and from low-input materials. Combining LiMCA and our high-resolution scATAC-seq assay, METATAC, we were able to profile the chromatin accessibility and the paired 3D genome structures and gene expression information of single neurons within the developing mouse olfactory epithelium. We expanded the repertoire of known OR enhancers, and discovered unexpected rules of their dynamics: ORs and their enhancers are most accessible during early differentiation, and the active OR typically does not associate with the largest enhancer hub. These findings offer valuable insights into how 3D connectivity of ORs and enhancers dynamically orchestrate the “one neuron–one receptor” selection process.
Relationship between stress hyperglycemic ratio and incidence of in-hospital cardiac arrest in patients with acute coronary syndrome: a retrospective cohort study
Authors: Li Kui , Yang Xueyuan , Li Yunhang , Xu Guanxue , Ma Yi
Published: August 2023

Background
Stress hyperglycemic ratio (SHR), a new marker that reflects the true hyperglycemic state of acute coronary syndrome (ACS) patients, is strongly associated with adverse clinical outcomes in these patients. Studies on the relationship between SHR and in-hospital cardiac arrest (IHCA) incidence are limited. This study aimed to elucidate the relationship between SHR and the incidence of IHCA in patients with ACS.
Methods
In total, 1,939 ACS patients who underwent percutaneous coronary intervention (PCI) at the Affiliated Hospital of Zunyi Medical University were included. They were divided into three groups according to the degree of SHR: group T1 (SHR ≤ 0.84, N = 646), group T2 (0.84 < SHR ≤ 1.14, N = 646) and group T3 (SHR3 > 1.14, N = 647). The primary endpoint was IHCA incidence.
Results
The overall IHCA incidence was 4.1% (N = 80). The results of restricted cubic spline (RCS) analysis showed that after adjusting for covariates, SHR was significantly associated with the incidence of IHCA in patients with ACS (odds ratio [OR] = 6.46; 95% confidence interval [CI] = 1.20–34.73; P = 0.030) and an increased risk of IHCA was observed in the T3 group compared with the T1 group (OR = 1.13; 95% CI = 0.43–2.97; P = 0.797). In the subgroup analysis of diabetes mellitus (DM) patients, those without DM history showed an elevated IHCA risk in the T3 group (OR = 3.34; 95% CI = 0.40–27.85; P = 0.265). After adjusting for covariates, patients with DM history also demonstrated a slightly increased IHCA risk (OR = 1.16; 95% CI = 0.17–7.70; P = 0.880). The subgroup analysis of patients with ST-segment elevation myocardial infarction (STEMI), non-STEMI (NSTEMI), and unstable angina pectoris (UA) revealed that, after adjusting for covariates, the risk of IHCA was increased in patients with UA in the T3 group (OR = 3.00; 95% CI = 0.23–39.13; P = 0.402). A dose-response relationship was observed between the incidence of IHCA and SHR, with higher SHR values (> 0.97) associated with an elevated risk of IHCA occurrence. Moreover, the area under the curve for SHR in predicting IHCA incidence in ACS patients was 0.64.
Conclusion
In ACS patients treated with PCI, SHR was significantly associated with the incidence of IHCA in ACS patients. SHR may be a useful predictor of the incidence of IHCA in ACS patients.
Single Image Reflection Removal with Reflection Classifier and Gradient Restorer
Authors: Xie Qing , Zhang Lingfeng , Ma Yanchun , Li Jiachen , Liu Yuhan
Published: August 2023

Techniques for removing image reflections can effectively eliminate artifacts superimposed on the subject due to factors such as reflections in light or through glass. Most current methods are designed on the assumption that reflection areas maintain the original image content. However, the neglect some extreme cases where there is no original information left, such as photos taken in museums with generated light spots.In this paper, we propose a novel model capable of further removing light spots reflections. Specifically, it takes an image with reflection contamination as input, and then guided by the proposed reflection classifiers and structure restorer, ultimately outputs a predicted transmission layer image.Experimental results demonstrate that the proposed model is applicable to different categories of reflection images, outperforming state-of-the-art reflection removal techniques.In summary, the proposed model improves the effect of image reflection technology based on artificial intelligence(AI) in the case of spot reflection.
Grief Responses During the COVID-19 Pandemic: A Qualitative Study in Spain
Authors: Redondo-Armenteros Andrea , Pérez-Marfil María Nieves , Fernández-Alcántara Manuel , García-Caro María Paz , Cabañero-Martínez María Josefa , Cruz-Quintana Francisco
Published: August 2023

Introduction: The recent COVID-19 pandemic led to a rise in the number of people bereaved by the death of a loved one. There are many pandemic-related stressors that may have further complicated grief in these people. The aim of this research was to analyse the shared experiences and strategies of those who lost a loved one during the pandemic.
Method: The sample consists of 42 participants who lost loved ones to COVID-19 or other causes (both natural and sudden). An inductive approach using grounded theory with open, axial and selective coding was used to analyse the semi-structured open-ended interviews.
Results: The resulting theory was structured around a central category: “Processes of Loss and Grief in Pandemics". The other relevant and related categories were: disease processes during the pandemic, emotional responses to the loss, factors facilitating the grieving process and obstacles to the grieving process. The various analytical categories were then further classified with reference to the Dual Process Model.
Conclusion: This study highlights the main features of grief during the pandemic, including the impact of restrictive measures on disease processes, the funeral rituals performed and subsequent coping; responses such as intense shock, anger, fear or loneliness; and the way in which facilitating factors of the grief process were adapted to the circumstances.
Identification and Validation of Lipid Metabolism-related Key Genes as Novel Biomarkers in Acute Myocardial Infarction and Pan-cancer Analysis
Authors: Xiao Hao , Gao Hengbo , Yao Dongqi , Cui Xiaolei , Liu Liang , Lv Baopu , Zheng Tuokang , Zhang Rui , Meng Qingbing , Li Yi , Gu Xinshun , Tian Yingping
Published: August 2023

Background
Acute myocardial infarction (AMI) is associated with high morbidity and mortality, and is associated with abnormal lipid metabolism. We identified lipid metabolism related genes as biomarkers of AMI, and explored their mechanisms of action.
Methods
Microarray datasets were downloaded from the GEO database and lipid metabolism related genes were obtained from Molecular Signatures Database. WGCNA was performed to identify key genes. We evaluated differential expression and performed ROC and ELISA analyses. We also explored the mechanism of AMI mediated by key genes using gene enrichment analysis. Finally, immune infiltration and pan-cancer analyses were performed for the identified key genes.
Results
TRL2, S100A9, and HCK were identified as key genes related to lipid metabolism in AMI. Internal and external validation (including ELISA) showed that these were good biomarkers of AMI. In addition, the results of gene enrichment analysis showed that the key genes were enriched in inflammatory response, immune system process, and tumor-related pathways. Finally, the results of immune infiltration showed that key genes were concentrated in neutrophils and macrophages, and pan-cancer analysis showed that the key genes were highly expressed in most tumors and were associated with poor prognosis.
Conclusions
TLR2, S100A9, and HCK were identified as lipid metabolism related novel diagnostic biomarkers of AMI. In addition, AMI and tumors may be related through the inflammatory immune response.
uniHEART: An Ensemble Atlas of Cardiac Cells Provides Multifaceted Portraits of the Human Heart
Authors: Zhang Xuegong , Chen Yixin , Hua Kui , Xu Shuhuan , You Renke , Hao Minsheng , Li Wenrui , Wei Lei , Jia Jinmeng , Xi Xi , Chen Sijie , Bian Haiyang , Ye Mingli , Chen Amin , Geng Yu , Liu Lianfeng , Luo Jiangying , Fei Jintao , Lv Hairong , Zhang Ping , Jiang Rui
Published: August 2023

The heart maintains its essential role in human life by the highly orchestrated functioning of specialized cell types. Recent advances in single-cell and single-nuclei RNA sequencing (scRNA-seq and snRNA-seq) provides the possibility of profiling the molecular and cellular characteristics of heart cells. We collected scRNA-seq and snRNA-seq data of healthy human hearts from all available sources and built the first human ensemble heart cell atlas, uniHEART, using a unified information framework for cell-centric atlas assembly. The current version of uniHEART contains 1,025,739 cells from 65 human heart samples, covering 19 major cell types in adult and developing human heart. The samples are from 10 anatomic regions of the heart, with age of the donors ranging from 5 weeks of the fetus to 75 years old. With this ensemble cell atlas, we constructed the multifaceted cellular and molecular portraits of the human heart by its anatomic parts, cell types and interactions, gene expression and networks. A rich interactive portraiture web system is provided for users to explore the atlas. With uniHEART, we discovered the molecular changes in the heart endothelial cells during aging and explored the disease therapeutic target cell-types. These case examples showed that uniHEART provides a holographic cellular reference for future studies on the human heart.
Determination of Glycyrrhizic Acid by Methyl Violet Dual-wavelength Superimposed Visible Spectrophotometry and its Analytical Applications
Authors: Chu Wen , Huang Dianyu , Tian Mei , Ma Weixing
Published: August 2023

An indirect determination method for glycyrrhizic acid in health foods was established using a dual-wavelength superposition visible spectrophotometric technique. The method relies on the reaction between diammonium glycyrrhizinate and the cationic dye methyl violet. In Clark-Lubs buffer solution at pH 3.0, diammonium glycyrrhizinate transforms into glycyrrhizinate, forming supramolecular aggregates with methyl violet through hydrogen bonding. This results in positive and negative absorption peaks in the visible region, with the maximum positive absorption occurring at 564 nm and the sub-maximum negative absorption at 676 nm. The respective molar absorption coefficients are 2.77×105 L/(mol·cm) and 1.53×105 L/(mol·cm). However, when utilizing the dual-wavelength superposition method, the molar absorption coefficient becomes 4.28×105 L/(mol·cm). The linear range for diammonium glycyrrhizinate determination is 1.00–2.50 mg/L, with a correlation coefficient of 0.9997 and a detection limit of 0.54 mg/L. This proposed method offers an indirect means to determine the glycyrrhizic acid in health foods. The measured values' relative standard deviation (n = 6) was consistently within 5%, indicating satisfactory results.
miR-377 regulates the tumorous behaviors of prostate cancer cells by targeting of MYC mRNA via its interaction with BCL-2/Bax, PTEN, and CDK4
Authors: Azimi Yasamin , Hajibabaei Sara , Azimi Ghazal , Rahimi-Jamnani Fatemeh , Azizi Masoumeh
Published: August 2023

Background: The MYC gene is one of the regulatory and proto-oncogenic genes overexpressed in most prostate cancers (PCa). Studies have shown that abnormal expression of microRNAs is involved in the onset and development of many different types of human cancer, including prostate cancer.
Methods and result: In this study, we first evaluated targeting the effect of miR-377 on MYC by luciferase assay. Real-time PCR was used to determine whether miR-377 could decrease the MYC mRNA in transfected PCa cell lines (PC-3 and DU145). Also, the expression of BCL-2/Bax, PTEN, and CDK4 mRNA levels were measured due to MYC degression. Also, the effects of miR-377 on apoptosis cells, proliferation, cell cycle, and wound healing were analyzed. We showed that miR-377 targets MYC mRNA by luciferase reporter assay. A significant reduction in MYC mRNA level was detected following miR-377 transfection in PC-3 and DU145 cell lines. Also, we demonstrated the decrease of BCL-2 and CDK4 and an increase in Bax, and PTEN in prostate cancer cell lines, following the reduction of MYC. Furthermore, we showed that the higher levels of miR-377 in PCa cell lines induced apoptosis, reduced proliferation, and migration, and stopped the cell cycle.
Conclusion: All these data reveal that miR-377 functions as an MYC inhibitor in PCa and may serve as a potential therapeutic target for treating this cancer.
An New Image Watermarking Scheme Based on Gerchberg-Saxton Algorithm and Integer Wavelet Transform
Authors: zhang Chaoxia , Liang Kaiqi , zhang Shangzhou , chen Zhihao
Published: August 2023

This paper combines Gerchberg-Saxton (GS) algorithm with the integer wavelet transform (IWT) and proposes an image watermarking encryption scheme with better security, stability and imperceptibility. Firstly, the Fourier transform domain's modulus is replaced by the known amplitude information by the iterative principle of the GS algorithm. The noise-like initial image can be obtained when the similarity satisfies certain constraints. Then, variable step Joseph space scrambling and pixel value bit processing are used to enhance anti-interference ability. Finally, IWT decomposes the cover image into four subbands with different frequencies. After embedding all the information of the secret image into each sub-band bit by bit, the visually significant cypher image is obtained, highlighting the imperceptible characteristics. The carrier and the regular images' hash values are calculated using the SHA-256 function. The RSA mode is used to update the key as the initial value of the hyperchaotic system while enhancing the security of the key, producing the password stream encrypted and embedded. The innovation of this paper is the introduction of the GS algorithm, which converts the image amplitude information into phase information and encrypts it as the initial image. Simulation experiments and in-depth performance analysis confirm the proposed method's efficacy and security.
An Accumulation Rate Curve Estimator for Total Species
Authors: Shestopaloff Konstantin
Published: August 2023

In this paper we present an estimator for total species that is based on modelling an accumulation rate curve. The proposed approach calculates the curve for the rate of arrival of new species conditional on the observed data and projectes it forward using parametric functions with varying rates of decay. The individual fits are integrated to obtain estimates for undetected species and a weighted estimate is obtained by optimizing a loss function subject to a set of restrictions. Confidence intervals are obtained using a parametric bootstrap of aggregate counts, with the underlying count covariances estimated from a regularized mixture distribution fit to the observed count data. A technique to adjust the point estimate for bias is also discussed. The method is tested using a simulation study and two data examples. The results indicate that the proposed method is robust in a majority of cases and largely outperforms existing methods in bias and mean squared error. Performance is especially improved when the proportion of unobserved species is high. Confidence interval coverage probabilities are noticeably better compared to existing methods and conservative interval widths are maintained. The bias adjustment technique is also shown to be effective in reducing mean squared error.
UV Reflectance of Spacecraft Materials and Analog Soils: Implications for Bioburden Reductions on the Undersides of Mars Rovers
Authors: Schuerger Andrew C. , Moores John E.
Published: August 2023

The Mars Sample Return mission architecture will utilize three spacecraft to collect, cache, recover, launch, and return to Earth a diversity of regolith and rock samples. However, no comprehensive Mars Microbial Survival (MMS) model currently exists. As an initial effort in building a MMS model, we examined the UV reflectance of 15 spacecraft materials and seven Mars analog soils within the context of the Perseverance mission. Data were used to predict the times required to achieve one lethal dose (syn., Sterility Assurance Level [SAL]; def. as a bioburden reduction of ‒12 logs). Results suggest that a single SAL dosage of UVC was achieved on exposed surfaces on the upper deck of Perseverance within a few hours to a few sols post-landing at Jezero Crater. The overall average for UVC reflectance from spacecraft materials was approx. 10%. The overall UVC reflectance from Mars analog soils was measured at 1.3%. The Adaptive Caching Assembly (ACA) on Perseverance is located on the forward edge of the underbelly of the spacecraft. Modeling of the accumulated UVC dosage for the ACA yielded a prediction of reaching one SAL for downward facing surfaces at 93 sols that receive ‘single bounce’ UVC photons from the local terrain. The SAL increases to 930 sols, if an additional ‘bounce’ of the solar UV irradiation is required to reach a partially protected site in the ACA hardware. The current study is the first to report on the UVC reflectance from a diversity of spacecraft materials.
Advancing Emergency Preparedness, Resilience and Response through High-Fidelity Simulation: A scoping literature review.
Authors: Newton Jon , Critchley Anya
Published: August 2023

Background: The sudden and often unexpected occurrence of major incidents routinely presents challenging and unpredictable working environments for emergency service personnel. Effectively training those with a response role is therefore of fundamental importance and vital for embedding resilience within organisations. NHS England’s Emergency Preparedness, Resilience and Response (EPRR) Framework stipulates the training requirements organisations should employ, yet limited guidance exists to support the educational quality or tangible outputs the table-top scenarios and ‘live-play’ exercises should provide. In recent years, High-Fidelity Simulation (HFS) has gained recognition as an effective method for advancing clinical acumen within this domain, yet few studies have attempted to validate its capability for cultivating psychological readiness and mental resilience.
Methods: To further teaching and learning practices we conducted a scoping literature review to ascertain if skills in critical thinking, emotional preparedness and mental resilience might be developed through the utilisation of HFS for major incident training.
Findings: In all six studies returned by our search strategy, HFS was universally found to enhance critical thinking skills and decision-making. However, no studies have yet been conducted which formally evaluate developments in emotional preparedness and mental resilience.
Conclusion: A sparsity of high-ranking evidence currently exists to guide teaching and learning developments within major incident training; and a research-knowledge gap for developing emotional preparedness and mental resilience has been identified. Further targeted research is required to ascertain the true benefits of HFS and its potential role in supporting the EPRR Cycle of Preparedness.
Prevalência de Lesões Orofaciais em um Centro de Especialidades Odontológicas Localizado no Município de Venturosa-PE, Brasil: Estudo Transversal
Authors: Melo Herlla Sofia Sales de , Melo Rodrigo Henrique Mello Varela Ayres de , Melo Milena Mello Varela Ayres de , Melo Victor Leonardo Mello Varela Ayres de , Lima Lohana Maylane Aquino Correia de , Ponzi Elizabeth Arruda Carneiro , Melo Ricardo Eugenio Varela Ayres de
Published: August 2023

Introdução: De acordo com o Instituto Nacional de Câncer (INCA), no ano de 2022 o câncer oral ocupou a quinta posição em prevalência no sexo masculino e a décima terceira em mulheres. Além disso, no Brasil as neoplasias malignas cutâneas são as mais comuns, especialmente o câncer de pele não melanoma. Objetivo: Compreender a prevalência e epidemiologia do câncer orofacial na população estudada. Material e Método: Trata-se de um estudo observacional transversal, no qual foi avaliada a prevalência de lesões em boca e face e os aspectos clínicos e sociodemográficos associados ao diagnóstico, em um Centro de Especialidades Odontológicas localizado no interior pernambucano. Resultados: 116 indivíduos participaram do estudo, 51,72% (n=60) da amostra tinham problemas dentários, 35,34% (n=41) apresentaram lesões em face, 7,75% (n=9) demonstraram lesões localizadas em boca, 5,17% (n=6) apresentaram disfunção da articulação temporomandibular ou outro problema. No tocante às lesões orofaciais, a distribuição por sexo demonstrou prevalência de 60,0% em mulheres e 40,0% em homens. 58% dos indivíduos eram leucodermas e 42% melanodermas. 56,0% identificavam-se como agricultores. Não foi diagnosticada nenhuma neoplasia maligna intraoral, mas identificou-se uma lesão com potencial de malignização, a queilite actínica. Isolando-se as lesões em face, 14,63% foram representadas pelo carcinoma basocelular e 26,82% pelo nevo melanocítico. Conclusão: O estudo demonstrou maior prevalência de lesões faciais em relação às orais, justificada pelo alto índice de exposição desprotegida à radiação solar. Dentre as lesões faciais, carcinoma basocelular e nevo melanocítico merecem destaque. Assim, fazem-se necessárias medidas preventivas efetivas direcionadas para grupos de maior risco.
Narratives of Resistance Towards Stigmatised Refugee Identities in Malaysia
Authors:   Faculty of Languages and Linguistics, Universiti Malaya, 50603 Kuala Lumpur, Malaysia, Lee Charity
Published: August 2023

The tendency to frame refugees as problems and threats has often fuelled negative attitudes among residents of the host countries towards refugees. This can contribute to overall hostile dominant discourses surrounding asylum seekers and refugees. Guided by narrative analysis, this article examines how refugees living in Malaysia cope with stigma through their personal narratives of the refugee experience. The topic is particularly relevant in the Malaysian context due to an increase in recent years in the visibility and the numbers of refugees and asylum seekers in Malaysia, of whom about 182,780 are registered but have no legal status, leading to barriers to protection rights and assistance during their displacement. The narratives presented here provide some description of how refugees in Malaysia experience stigma and the ways in which they have navigated hostile situations. More importantly, the narratives display awareness of the stigmatised identities imposed on refugees and illustrate the range of narrative strategies available to refugees to resist and offer alternative ways of being. These strategies include blaming or rejecting the discrimination, appropriating the Malaysian identity, assuming the good citizen identity, and passing for another person.
Effect of chlorine substitution on the thermal stability of ferro-pargasite and thermochemical properties of ferro-chloro-hornblende
Authors: Jenkins David M.
Published: August 2023

Substitution of chlorine for hydroxyls in calcium amphiboles has been widely documented, but the effect of this substitution on thermal stability is not known. Experimental reversal data are presented here comparing the upper-thermal stability of amphiboles formed in the ferro-pargasite and ferro-chloropargasite bulk compositions. Experiments were made over the range of 550–900 °C and 0.5–3 kbar at oxygen fugacities of log(fO2) of –0.3 to +0.5 relative to Co-CoO. Electron microprobe analysis of amphiboles made from the ferro-pargasite bulk composition were found to be ferro-pargasite, while those made from the ferro-chloro-pargasite bulk composition were low in A-site Na and Cl and were better classified as Cl-bearing ferro-ferri-hornblende. Although the differences between desired and observed amphibole compositions complicate the comparison of their thermal stabilities, it can be deduced that the Cl-bearing amphibole has a steeper dP/dT slope and, above 1 kbar, a lower thermal stability than ferro-pargasite. Thermodynamic analysis of the Cl-bearing amphibole was also done to extract thermochemical data for the Cl end-member amphibole ferro-chloro-hornblende [Ca2(Fe4Al) (AlSi7)O22Cl2 = Fe-Cl-Horn] that are consistent with the thermodynamic database of Holland and Powell (2011). Using an ideal-activity expression and estimated values for the heat capacity (CP = 1.106 + 8.9156 × 10–5(T, K) – 11 218.3/T2 – 5.9548/T0.5; kJ/K·mol) and volume (283.0 ± 1.5 cm3/mol) for Fe-Cl-Horn, the derived values for ΔHf∘ and S° are –10 842.6 ± 10.3 kJ/mol and 618.8 ± 11.1 J/K·mol, respectively. The implication of this work is that (1) chlorine appears to lower the thermal stability of a given calcium amphibole in contrast to the marked increase in thermal stabilities caused by fluorine, and (2) thermochemical data such as those derived in this study allow absolute concentrations of chloride salts to be calculated in metasomatic paleobrines, as illustrated for the Bamble sector of southern Norway reported in the literature.
Universality in Anderson localization on random graphs with varying connectivity
Authors: Sierant Piotr , Lewenstein Maciej , Scardicchio Antonello
Published: August 2023

We perform a thorough and complete analysis of the Anderson localization transition on several models of random graphs with regular and random connectivity. The unprecedented precision and abundance of our exact diagonalization data (both spectra and eigenstates), together with new finite size scaling and statistical analysis of the graph ensembles, unveils a universal behavior which is described by two simple, integer, scaling exponents. A by-product of such analysis is a reconciliation of the tension between the results of perturbation theory coming from strong disorder and earlier numerical works, which seemed to suggest that there should be a non-ergodic region above a given value of disorder W_{E}WE which is strictly less than the Anderson localization critical disorder W_CWC, and that of other works which suggest that there is no such region. We find that, although no separate W_{E}WE exists from W_CWC, the length scale at which fully developed ergodicity is found diverges like |W-W_C|^{-1}|W−WC|−1, while the critical length over which delocalization develops is \sim |W-W_C|^{-1/2}∼|W−WC|−1/2. The separation of these two scales at the critical point allows for a true non-ergodic, delocalized region. In addition, by looking at eigenstates and studying leading and sub-leading terms in system size-dependence of participation entropies, we show that the former contain information about the non-ergodicity volume which becomes non-trivial already deep in the delocalized regime. We also discuss the quantitative similarities between the Anderson transition on random graphs and many-body localization transition.
AN EXPLORATORY STUDY TO ASSESS THE PREVALNCE AND CONTRIBITING FACTORS OF SOCIAL ANXIETY AMONG ADOLSCENTS RESIDING IN SELECTED COMMUNITY AREA AT MEERUT
Authors: Singh Himani , a Aditya , b Jyoti , G. Nisha
Published: August 2023

Statement of the study An exploratory study to assess the prevalence and contributing factors of social anxiety among adolescents residing in a selected community area at Meerut. Objective:- 1. To assess the prevalence of social anxiety among adolescents 2. To identify contributing factors of social Anxiety among adolescents 3. To find out the association between level of social Anxiety with selected demographic variables Methododlogy: A quantitative research approach and descriptive research design was used in this study. Sample size is 60 in the age group of adolescents, which is having categories ( early, middle, late ) adolescents was selected by purposive sampling technique. The gathered data was analyzed by the using of descriptive and inferential statistics. Result: The finding shows that out of 60 sample , 21(35%) are having moderate social anxiety, 26(43.4%) are having marked social anxiety, 13(21.6%) are having severe social anxiety. Conclusion: The study revealed that most of the adolescents are having marked social anxiety. There was no significant relation between the sociodemographic variable and the social anxiety.
STUDY OF VITAMIN B12 LEVELS IN PATIENT WITH TYPE 2 DIABETES MELLITUS
Authors: Patel Jay
Published: August 2023

Aims :-Evaluation of serum Vitamin B12 levels in type 2 diabetic population. Objectives:-1) To define the prevalence of vitamin B12 deficiency in type 2 diabetic population.2) To determine the risk factors associated with Vit B12 deficiency in type 2 diabetes like Age and Metformin use.3) To Assess the co-relation of Serum B12 levels and Diabetic Retinopathy in Type II Diabetes mellitus. Material and Methods:-This case control study was conducted in OPD of Department of General Medicine, Sarvajanik Hospital, Pune between June 2012 to May 2013. A total of 50 type 2 Diabetes Mellitus patients and 50 controls between 40 to 60 years were included. Serum Vitamin B12 levels and serum homocysteine levels were measured in all patients. Results:-The Vitamin B12 deficiency was present in 56% of the diabetics and 32% of the non-diabetics. Vitamin B12 deficiency was present in 48.4% of patients who were not on metformin and 68.4% of than those were on metformin. No significant increase in the prevalence of neuropathy, anaemia, or MCV was found in the Vitamin B12 deficient patients as compared to patients with normal Conclusions:- The study has shown that the diabetes was common after the age of 40 years. Male sex, Overweight and Obesity were other risk factors. Majority of the patients in this study had the diabetes more than 5 years and their blood sugar markers were disturbed. This study has shown that the vitamin B12 deficiency was found in more than half of the diabetics, metformin users and those who were on vegetarian diet.
DESIGN AND IMPLEMENTATION OF SRAM 6T FOR 2 BYTES
Authors: Kumar Sai Ramesh Kishan
Published: August 2023

SRAM has become a significant segment in numerous VLSI Chips because of their huge stockpiling thickness and little access time. SRAM has gotten the theme of impressive research because of the fast improvement for low power, low voltage memory structure during late years because of increment interest for scratch pad, workstations, IC memory cards and specialized gadgets. SRAMs are broadly utilized for versatile and PC applications as both on chip and off-chip recollections, in view of their accessibility and low backup spillage. The fundamental target of this paper is assessing execution regarding Power utilization, deferral and Signal to Noise Margin of existing 6T SRAM cell in 45nm and 180nm innovation.
CHALLENGES AND RESPONSES TO THAILANDS ECONOMIC AND TRADE DEVELOPMENT UNDER CHINAS BELT AND ROAD INITIATIVE
Authors:   Department of Law, International College, Krirk University, Thailand., Wu Bingyang , Hsieh Ming-Hsun ,   Dean, Faculty of Liberal Arts, Krirk University, Thailand.
Published: August 2023

As an important node country of the the Belt and Road, Thailand has natural geographical location advantages, natural resources advantages and trade complementary advantages. This research takes Thailand as the research object. Through studying the related concepts and basic theories of the the Belt and Road, it focuses on analyzing the strategic design, development goals, planning direction and other issues of the the Belt and Road, and takes this as the theoretical research basis to analyze the current situation of China-Thailand economic and trade, and link the the Belt and Road initiative with Thailands economic and trade development.
STEM CELLS IN REGENERATIVE MEDICINE AND THERAPEUTIC POTENTIAL
Authors: A.K Lathif , P. Keerthi
Published: August 2023

Stem cells are a form of undifferentiated cell that has the potential to proliferate (self-renew), emerge from a single cell (clonal), and develop into different types of cells and tissues (potent). There are several sources of stem cells of varied potency.Although stem cell research has grown at an exponential rate, medicinal applications have moved considerably more slowly. The study is currently focused on understanding embryonic, adult, and inducible pluripotent stem cells. Adult stem cell research translation has demonstrated a decisive benefit that is larger than the present standard of care in the field of cardiovascular medicine. The future of stem cell research and therapy will continue to open up new diagnostic, therapeutic, and tissue regeneration pathways.In cellular treatment, stem cells can be employed to repair damaged cells or rebuild tissues. Furthermore, stem cells have advanced our understanding of development as well as disease causation. Cell lines that are particular to a disease can also be grown and employed in medication research.Despite considerable improvements in stem cell biology, ethical concerns about embryonic stem cells, tumour growth, and rejection restrict their applicability. However, several of these constraints are being overcome, which might lead to significant advancements in illness management. This article provides an introduction to the world of stem cells, including its definition, origin, and categorization, as well as their uses in regenerative medicine.
THE INFLUENCE OF ORGANIZATIONAL CULTURE AND COMPENSATION SATISFACTION ON WORK MOTIVATION AMONG SECONDARY SCHOOL TEACHERS
Authors:   Capitol University, Cagayan de Oro City, Philippines., D. Malawani Aynee , Raymond S. Tan Mark ,   Capitol University, Cagayan de Oro City, Philippines.
Published: August 2023

The primary objective of this research was to assess the influence of organizational culture and compensation on work motivation among public school teachers in Lanaodel Sur II. The study utilized a descriptive-correlational research design and employed proportional stratified random sampling. To analyze the data collected from the survey questionnaire, descriptive statistics such as mean and standard deviation, inferential statistics including correlation, ANOVA, and multiple regression analysis were used.As revealed, the study divulged that the organizational culture of the participants had a very high level in terms of involvement, adaptability, and mission, while they only got a high level in consistency. As disclosed, the study revealed that the work compensation satisfaction of the participant in terms of Salary, Rank, and Employment Status was satisfied. Additionally, the statistical analysis revealed that there was a significant difference in the assessment of participants organizational culture only in relation to the variable salary while the other profile variables (age, gender, length of service, rank, and employment status) was found to have no significant differences. The regression coefficient for predicting work motivation using organizational culture and compensation satisfaction was statistically significant, indicating a significant association between organizational culture and compensation satisfaction and work motivation.Furthermore, the findings underscore the significance of creating a positive work environment and fair and competitive work compensation in enhancing teacher motivation, ultimately leading to improved educational outcomes.
ROLE OF NCLT IN IMPROVING CORPORATE GOVERNANCE IN INDIA: A DESCRIPTIVE ANALYSIS
Authors:   Associate Professor Motilal Nehru College University of Delhi., Karki Chandan
Published: August 2023

On the event of India Today conclave 2023, the Honble Prime Minister of India on 18th March 2023, recognized the contribution of National Company Law Tribunal (NCLT) in strengthening the corporate governance practices in India. It imposes a curiosity in any research oriented mind that how the principles embodying the NCLT becoming one of the contributing factor for good corporate governance for the India Inc. In the merger and arrangement cases the NCLT has efficiency of the 93 %. In the oppression, mismanagement and other cases the efficiency counted at 80 %. Similarly in the insolvency dispute cases the efficiency is counted at 86 % in totality and the total amount involved in the settlement was more than â‚¹ 10,49,264 crore. Keeping in view the size of the corporate world operating in and through India, there need to be strengthening of the NCLT window in terms of resources and providing other jurisdictions to adjudicate the matters. The independence and machinery of the NCLT should be safeguarded and preserved.
AKSHI TARPANA: A BLISS TO SIGHT
Authors:   PG Scholar, Department of Panchkarma, Dayanand Ayurvedic College and Hospital, Jalandhar, Punjab, India., a Sushmita , Kumar Parveen ,   Associate Professor, Department of Panchkarma, Dayanand Ayurvedic College and Hospital, Jalandhar, Punjab, India.
Published: August 2023

Akshi is the most crucial Gyan Indriya. In this digital era,the use of digital screens is quite common and resulting in various Akshi Rogas. Sushruta, the father of surgery, has recommended Kriyakalpa for the management of Akshi Rogas. Among all Kriyakalpas, Akshi Tarpana is the useful procedure in various Akshi Rogas,considering severity of Dosha PrakopaandAdhishtana of diseases. It acts as both preventive and curative therapy for maintaining normal healthy condition of eyes. According to modern pharmacology, the medicatead Ghrita used for the Tarpana procedure is processed with decoction of medicine hence the drug may easily cross the corneal epithelium (being lypophilic) and endothelium (being hydrophilic). Finding an ocular method with no or minimal side effects is crucial for the prevention and treatment of eye illnesses. When applied quickly, one local therapeutic method called Tarpana Karma has good results, according to objective research. So, taking a look at the traditional Ayurvedic text a method of treatment used to treat is Akshi Tarpana. In this article the texts of BrihattrayiandLaghutrayihave been reviewed to extract the information about Akshi TarpanaKarma, its indications, contraindications and possible mode of action.This work has revealed that Akshi Tarpana is useful in most of the disorders caused due to vitiation of different Doshas as well as disorders of different parts (Adhishtana) of the eye. Its complications with AtiYoga and HeenaYoga and their management is also been discussed.
INTERVENTION PROGRAM FOR THE DEVELOPMENT AND CULTIVATION OF THE SOFT SKILL OF RESPECT IN STUDENTS WITH DISABILITIES STUDYING IN A SPECIAL CONTEXT
Authors: Ioannis Novakos
Published: August 2023

The area of Special Education and Education is an educational system whose tracing and traversal constitutes a difficult undertaking and action. In this sense, the essential, efficient and effective teaching of soft social skills and, above all, respect, to students with disabilities who study in special contexts and structures is very laborious. With this specific scientific and critical review, the design, implementation and evaluation of an intervention program for the development and cultivation of the soft skill of respect for students with disabilities is investigated and discussed. Based on the review findings of this research, it is demonstrated that intervention programs, in the context of respect, should aim at the development of a specific soft skill and not, in a general and vague way, at the improvement of all soft skills.