bluuebunny/crossref_metadata_2025 huggingface dataset:
ESTADO NUTRICIONAL E CRESCIMENTO DE CRIANÇAS QUILOMBOLAS DE DIFERENTES COMUNIDADES DO ESTADO DO PARÁ
Authors: Guimarães Raissa Cecília Rosalino , Silva Hilton P.
Published: June 2016

Neste artigo são avaliados o estado nutricional e o crescimento de crianças de três comunidades quilombolas vivendo em diferentes condições sócio-ecológicas no Estado do Pará. Trata-se de um estudo de delineamento transversal constituído por 48 crianças de 0 a 5 anos de idade, representando mais de 70% desta faixa etária nos quilombos Santo Antônio, África/Laranjituba e Mangueiras. A antropometria seguiu técnica padronizada internacionalmente e os dados foram convertidos em escores-Z utilizando-se o programa WHO-Anthro. Os índices Peso/Estatura (P/E), Estatura/Idade (E/I), Peso/Idade (P/I) e o Índice de Massa Corporal/Idade (IMC/I) foram os descritores do estado nutricional. Observa-se que um elevado percentual de crianças apresenta desvios em relação aos padrões de crescimento preconizados nas curvas internacionais de referência. Ao avaliar os índices P/E e IMC/I, se encontram percentuais consideráveis de crianças acima do escore-Z +1, totalizando 29,9% da amostra, evidenciando casos de sobrepeso e obesidade. Entretanto, ao analisar E/I, 31,1% das crianças estão abaixo do escore-Z -2, mostrando que o déficit estatural ainda é um problema entre a população infantil destes remanescentes de quilombos. Nota-se que as crianças quilombolas analisadas ainda apresentam dificuldades em atingir seus potenciais de crescimento, entraves potencialmente relacionados com as características sócio-demográficas, sanitárias e ecológicas nas quais estas populações se encontram. Concomitantemente a casos de desnutrição, observa-se também excesso de peso em algumas crianças, ratificando o processo de transição nutricional ocorrendo na região amazônica. Palavras-chave: Crianças, quilombolas, avaliação nutricional, transição nutricional, Amazônia
La lectura paronomástica: Freud y Lacan por Haroldo de Campos
Authors: Lázaro Rosario , Costa Walter Carlos
Published: June 2016

Este artículo propone una lectura de la relación que establece Haroldo de Campos con el psicoanálisis en el ensayo “O afreudisíaco Lacan na Galáxia de lalíngua (Freud, Lacan e a escritura)”, teniendo como eje articulador la traducción paronomástica y las implicaciones en su visión sobre el lenguaje. Para tal fin, en primer lugar define la paronomasia como figura retórica y su lugar dentro de la poesía concreta. A continuación, destaca algunos de los postulados de la poética de la traducción concreta presentes en el mencionado ensayo de Campos, buscando evidenciar hasta qué punto el acercamiento a Freud y a Lacan se produce por la vía de una poética basada en la paronomasia.
O desenvolvimento de um projeto de educação linguística para o ensino-aprendizagem de alemão a partir da pluralidade linguística e cultural dos alunos
Authors: PREDIGER Angélica , KERSCH Dorotea Frank
Published: June 2016

Resumo: O ensino de alemão no Brasil tem se focado no desenvolvimento das quatro habilidades – ler, escrever, falar, ouvir. As variedades de alemão faladas no lar são invisibilizadas, assim como outras línguas faladas na comunidade dos alunos. Neste artigo, refletimos sobre a pluralidade linguística e cultural como ponto de partida para o desenvolvimento de um projeto de educação linguística realizado com alunos que menosprezavam a sua origem cultural e a dos colegas. O posicionamento dos alunos, em sala de aula, apontava para atitudes negativas em relação às variedades alemãs faladas em casa e às línguas dos outros, consequentemente, em relação ao alemão ensinado na escola. Os resultados mostram que projetos de educação linguística, que transformem a diversidade linguística e cultural dos alunos em objeto de estudo, desenvolvem não somente capacidades de linguagem em alemão, mas também sensibilidade em relação à língua e cultura do outro. Ao longo da implementação do projeto, observou-se a emergência de atitudes positivas em relação aos colegas e em relação ao ensino-aprendizagem de alemão. Palavras-Chave: Projeto de educação linguística. Ensino de alemão. Diversidade linguística e cultural. Atitudes.
A produção escrita em turmas heterogêneas de português língua estrangeira
Authors: SALES Hellen Margareth Pompeu de , CUNHA José Carlos Chaves da
Published: June 2016

RESUMO: Apresentamos aqui os primeiros resultados de uma pesquisa-ação na qual experimentamos uma abordagem de ensino-aprendizagem da produção escrita que leva explicitamente em conta a heterogeneidade linguístico-cultural do público alvo. Nossa hipótese é a de que o trabalho docente e discente em turmas heterogêneas é favorecido quando se associa uma concepção de ensino-aprendizagem acional a uma concepção de língua-linguagem sócio interacionista. Nossos dados foram constituídos por 35 aulas de Português Língua Estrangeira –ministradas a uma turma onde estavam presentes dez línguas-culturas diferentes – e pelos textos escritos pelos alunos. O progresso constatado entre as produções iniciais e as finais destes, assim como os resultados que obtiveram nos exames do Celpe-Bras3 são indícios significativos de que esta abordagem pode ajudar na superação das dificuldades inerentes à heterogeneidade do público alvo. PALAVRAS-CHAVE: Heterogeneidade linguístico-cultural. Plurilinguísmo. Pluriculturalismo. Tarefas.
Didactics of plurilingualism and integrated intercomprehension: the case of Euromania
Authors: FONSECA Mariana , GAJO Laurent
Published: June 2016

By studying “integrated intercomprehension”, this article sheds new light on the didactic of plurilingualism. It offers a critical perspective on the notions of language awareness, knowledge integration and code alternation, that are variably present in plural approaches. By analysing recorded classroom sessions where Euromania is being used, we are able to observe with a great deal of detail how the process of integrating language and content unfolds through the alternation of different documents and languages. We conclude our discussion with some comments on the “didactisation” of this work in the classroom – especially the “strangeness” principle and the new perspectives opened by integrated intercomprehension – with regards to the discursive structure of documents and the enunciative structures used by students. This dimension, so far neglected, deserves special attention, as it allows us to monitor student progress in both language and content. KEYWORDS : Didactics of plurilingualism. Integrated intercomprehension. Integration. Strangeness. Code alternation (code-switching).
O trabalho com dicionários em sala de aula: relato de uma contribuição para a formação docente em lexicografia
Authors: Bolzan Rosane Maria , Durão Adja Balbino de Amorim Barbieri
Published: June 2016

O professor desempenha um papel fundamental na mediação entre dicionários e consulentes para a expansão dos conhecimentos de seus alunos. Neste artigo, relata-se uma experiência pela qual se objetivou capacitar professores no campo da Lexicografia, viabilizando um curso de formação nessa área no município de Garopaba/SC. Com o propósito de descobrir o perfil dos docentes e seus conhecimentos sobre dicionários, utilizaram-se questionários escritos como instrumentos de coleta de dados. O resultado demonstrou que as obras lexicográficas são subutilizadas, que não há acervo suficiente para realizar um trabalho apropriado em sala de aula, que não há tipos de dicionários adequados a seus usuários e também que os dicionários são obras desconhecidas da maior parte dos professores quanto ao seu potencial e características. Preconiza-se um investimento na formação de professores em Lexicografia, haja vista a realidade encontrada nesse grupo de professores participantes do curso sobre uso de dicionários em sala de aula.
Qu’est-ce que le travail?
Authors: Trinquet Pierre
Published: June 2016

Est-il pertinent de se demander: Qu’est-ce que le travail? La découverte, en 1972, de l’écart prescrit/réel, remet-elle en cause nos approches sur cette activité humaine? Pourquoi travaillons-nous réellement? Quelles sont les fonctions fondamentales du travail? Qu’est-ce que le savoir constitué et le savoir investi? Le bien-être en santé au travail est-il possible? Autant de questions sur cette activité humaine importante dans la vie de chacun et de notre espèce, auxquelles l’ergologie tente de répondre.
Da criação de espaços de dizer: (re)normalizações e usos de si no trabalho
Authors: Machado Ivete Bellomo , Di Fanti Maria da Glória Corrêa
Published: June 2016

Devido à importância do trabalho na sociedade contemporânea e à sua relevante e complexa relação com a linguagem, faz-se necessário desenvolver pesquisas focalizando a interface linguagem e trabalho sob o ponto de vista da atividade humana. Tomando como base teórica a perspectiva dialógica da linguagem em interlocução com os estudos ergológicos, buscamos, neste artigo, verificar aspectos do debate de normas e dos usos de si na atividade do trabalhador de uma empresa comercial. Como procedimentos metodológicos, criamos espaço de fala aos trabalhadores a partir de entrevistas individuais, as quais suscitam reflexões sobre a atividade realizada. Desse material, foram selecionados para a análise enunciados de dois trabalhadores entrevistados. Com esta investigação, buscamos contribuir para o (re)conhecimento da atividade laboral, levando em conta a complexidade das relações que se efetivam nesse espaço.
Análise do Discurso e Ergologia: o sujeito na atividade de trabalho
Authors: Motta Ana Raquel
Published: June 2016

Aborda-se aqui a noção de sujeito da Análise do Discurso, especialmente a partir de textos de Michel Pêcheux da década de 1980, para relacioná-la à noção de corpo-si da Ergologia, conforme postulada por Yves Schwartz. A partir dessa articulação, analisam-se canções de trabalho cantadas por prisioneiros em atividade coletiva de derrubada de árvores no Texas na década de 1960. Tal articulação contribui para que a AD possa analisar o “deslocamento tendencial do sujeito enunciador”, conforme noção postulada por Pêcheux (1981), e também para que a Ergologia possa complexificar sua compreensão de linguagem, considerando a opacidade do discurso. As considerações finais apontam para a ideia de que o debate de normas e valores, conceituado pela Ergologia, pode ser visto como o próprio objeto da Análise do Discurso, uma vez que inclui o interdiscurso e as práticas discursivas.
Uma espada através do corpo de Dilma Roussef: mídia, discurso e imagem
Authors: Silva Pollyanna , Hashiguti Simone Tiemi
Published: June 2016

Este trabalho tem o objetivo de discutir a relação entre imagem e texto verbal em um artigo de jornal, a partir de uma perspectiva discursiva. Partimos do pressuposto de que os recursos midiáticos – TV, rádio, jornais impressos e online – são espaços de notícias e instituições que difundem e regularizam saberes que circulam na sociedade, e que têm o poder de instaurar sentidos que são tomados como verdades inquestionáveis. Nas reportagens, pela costura e disposição dos elementos gráficos e textuais, esses veículos fazem mais ou menos visíveis assuntos, personagens e temas e organizam percursos de leituras e sentidos de determinados discursos. Para discutir esses aspectos em funcionamento, nosso material de análise compõe-se de uma página de jornal do Estado de S. Paulo, em que uma foto da presidente da República Federativa do Brasil, Dilma Roussef, foi publicada ao lado de uma notícia da qual a imagem não faz parte; criando, assim, um direcionamento de sentido. Assumimos o referencial teórico da Análise do Discurso de tradição franco-brasileira, principalmente os conceitos de enunciado e mecanismos de poder, propostos nos estudos foucaultianos sobre os saberes e discursos. Discutimos como a utilização da imagem descontextualizada de sua própria história, em meio ao texto verbal, é uma estratégia que visa repetir o sentido do texto verbal e estabilizar um determinado discurso.
The choice between conventional and organic farming. A Hungarian example
Authors: Fertő Imre , Forgács Csaba
Published: June 2016

The paper deals with organic produce in one of the largest and, concerning organic production one of the most diffused counties in Hungary, Pest County located in the north-central part of the country. Factors influencing farmers’decision on adopting or not e.g. farm size, farm type, location, structure, market for organic products, existence of organic AEM were analysed. Hypotheses based on previous empirical literature were tested by a model explicitly accounting for the effects of farm-specific variables like age, education, size of farms and share of rented land. Logit model was estimated on a cross-section data set of Hungarian farmers for the period 2007. It appears that education has a positive impact on the choice between conventional and organic farming, and, the size of the farm in hectares has a negative effect on this choice.Age and some general considerations on environmental friendly technologies do not have a significant effect on choice between conventional and organic farming.
An ICT-based traceability system in compound feed industry
Authors: Cebeci Zeynel , Erdogan Yoldas , Alemdar Tuna , Celik Ladine , Boga Mustafa , Uzun Yusuf , Coban H. Durdu , Görgülü Murat , Tösten Funda
Published: June 2016

The term traceability refers to recording of flow of products along the food chain from production to consumption with inclusion of all intermediate applications involved in processing/packaging stages. The aim for establishing traceability in the food chain is to provide the timely identification and recall of batches of product from the market when a risk threatens the health of consumers. Since compound feed products are basic inputs in livestock and poultry production, ICT-based feed traceability systems can be considered as a initial step in food traceability management. These systems are simply information recording systems that are designed to trace and track the flow and characteristics of animal feed along the feed supply chain. This paper describes the architecture and some functional properties of a feed traceability system called as the “feed TRace”, focusing particularly on compound feed and integrated poultry meat industries. The feedTRace aims to improve compound feed supply chain management, to increase feed safety and quality control, and to gain marketing competencies with traceable products in compound feed industry. The system is currently under beta stage, and is tested in two high capacity feed milling plants and an integrated broiler company located inAdana province of Turkey.
The role of corporate branding in Serbian mobile phone operator market
Authors: Vanka Gajo
Published: June 2016

This research is carried out to know the role of corporate branding in mobile phone network along with different influencing factors involved in the purchase of mobile telephone connections. This thesis discusses corporate branding from consumer’s point of view that how much they value it and what type of role it has.
The assessment of intellectual capital in Polish regions
Authors: Bronisz Urszula , Heijman Wim , Van Ophem Johan
Published: June 2016

In a knowledge-based economy intangible assets are indispensable to achieve competitive advantages. Resources like intellectual capital are perceived as crucial factors especially for regional growth. Intellectual capital is comprehended as a multidimensional concept, defined and explained in many various ways, depending on the context and further application. The purposes of this article is to consider the role and importance of the intellectual capital for regional development and competitiveness and to try to use it for an estimation of regional advance progress. On the basis of literature review the article provides a framework to analyse the intellectual capital and its main components. The central attention of the paper focuses on the evaluation of the intellectual capital in Polish regions and its influence on regional performance. The paper surveys the empirical examination of 16 Polish regions in terms of intellectual capital and simultaneously assesses the level of intellectual capital in rural areas. The article provides the insight into the role and value of the intellectual capital in Polish regions.
Comparative yield risk calculations of sour cherry and pear varieties regarding risk aversion
Authors: Persely Szilvia , Ertsey Imre , Ladányi Márta
Published: June 2016

Fruit production in the world is increasing continuously. Though in the past few years China and some South-American countries have extended their fruit producing areas, Europe remains to be one of the greatest fruit producers in the world. In the middle of Europe Hungary has to face several challenges as competing for market. Since yield risk has an important role in Hungarian fruit production we investigate the yield risk of two of the most important sour cherry varieties (’Újfehértói fürtös’ and ’Oblacsinszka’) grown in Újfehértó (1984-2005), moreover, two of the most important pear varieties (’Bosc Beurre’ and ’Williams’) grown in Bánfa and Zalasárszeg (1984-2009). In the examined periods we analyse yield risk with different comparative methods such as E,V-efficiency, first and second degree as well as generalized stochastic dominance methods. We conclude that the production of sour cherry variety ’Oblacsinszka’ in Újfehértó is more preferable compared to the other sour cherry varieties and pear variety ’Bosc Beurre’ in Bánfa is more advantageous than the other pear varieties and sites.
Effectiveness, efficiency and sustainability in local rural development partnerships
Authors: Kis Krisztián , Gál József , Véha Antal
Published: June 2016

Due to the ever-increasing role the LEADER approach is playing in realizing rural development policy, Local Action Groups (LAGs) have become key actors in the institutional system of rural development. Through their activity in supporting and improving local development, they represent a spatial organizing force in rural regions. Their operation can effectively contribute to the competitive and sustainable development of their local area, within the framework of European rural development policy. Compliance with this role requires the active and conscientious work of the LAGs, both in the process of programming and implementation. In this paper, we aim to present the impact mechanism of the operation of LAGs and its determinant factors. Based on expert evaluations, we investigate the experiences of the implementation of the LEADER approach for rural development from the viewpoints of effectiveness, efficiency and sustainability.
Consumo de alimentos y riesgo de malnutrición en personas muy mayores (80 años) de vida independiente
Authors: Jiménez-Redondo Susana
Published: June 2016

Introducción: existen pocos estudios que valoren el consumo de alimentos de la población muy mayor.Objetivos: evaluar el consumo de los grupos de alimentos (gramos y raciones) y su adecuación a las recomendaciones para la población ancianaespañola. Además se estudia su relación con el riesgo nutricional.Métodos: dentro del estudio transversal sociosanitario en mayores de Villanueva de la Cañada (Madrid), en 98 individuos ≥ 80 años (66% mujeres)se evaluó el consumo de alimentos a partir de un recuerdo-24 horas y el riesgo nutricional fue valorado mediante Mini Nutritional Assessment(MNA). La signifi cación estadística se evaluó a nivel de confi anza del 95% (p < 0,05).Resultados: los hombres consumieron signifi cativamente mayor cantidad de aperitivos y bebidas alcohólicas. El consumo de cereales y derivados(2 raciones/día), verduras y hortalizas (1,5 raciones/día) y alimentos del grupo carnes, pescados y huevos (1,4 raciones/día) no alcanzólas recomendaciones. Al empeorar el estado nutricional el consumo de frutas fue signifi cativamente menor (p = 0,039). Se han encontradocorrelaciones relativamente débiles, pero altamente signifi cativas entre el MNA y el consumo de aceites/grasas, frutas y bebidas alcohólicas.Tras ajustar la ingesta de energía, la asociación con los aceites/grasas y con las frutas desaparece mientras que surge una asociación negativacon el consumo de lácteos.Conclusiones: el patrón alimentario observado se desvía del mediterráneo tradicional. Así, aunque existe un consumo adecuado de lácteos,frutas, aceites/grasas y azúcares/dulces, el consumo de cereales y derivados, verduras y hortalizas y alimentos del grupo carnes, pescados yhuevos no alcanzó las recomendaciones. El deterioro del estado nutricional coincide con una disminución en el consumo de todos los grupos dealimentos menos en el caso de los precocinados y los lácteos cuyo consumo aumenta. La infuencia del consumo de fruta, lácteos, vino y aceitede oliva sobre el estado nutricional requiere más investigación.
Evaluación de la concordancia de dos métodos para determinar la distancia del desplazamiento activo al colegio en escolares
Authors: Villa-González Emilio
Published: June 2016

Objetivo: analizar la concordancia de dos métodos de medición (Google MapsTM vs. Sistema de Información Geográfi ca) para la determinaciónde la distancia desde el domicilio familiar hasta el colegio.Métodos: un total de 542 escolares de entre 8-11 años de edad (media = 9,36 ± 0,6) del sur de España participaron en el estudio, facilitando ladirección de su domicilio familiar. La distancia desde el domicilio familiar al colegio se calculó mediante la utilización de dos programas diferentes:Google MapsTM y Sistema de Información Geográfi ca (GIS) en ruta y en línea recta. La asociación entre ambos métodos fue analizada utilizandola correlación de Spearman y el grado de acuerdo a través del coefi ciente de correlación intraclase (ICC), así como el método Bland Altman.Resultados: la correlación entre ambos métodos de medición propuestos fue muy signifi cativa (r = 0,966, p < 0,001; r = 0,984, p < 0,001; y r= 0,954, p < 0,001, respectivamente), y la concordancia fue excelente (ICC = 0,96, p < 0,001; ICC = 0,92, p < 0,001; ICC = 0,97, p < 0,001).Conclusiones: los métodos de medición estudiados podrían ser utilizados en función de las necesidades de la investigación, al presentar ambosuna alta concordancia. Sin embargo, se recomienda la utilización del Sistema de Información Geográfi ca en ruta si se cuenta con medios yfi nanciación, por tratarse de un método constatado en fi abilidad y validez.
RESILIENSI KELUARGA PADA PASANGAN USIA PARUH BAYA
Authors: Rohmah Umi
Published: June 2016

Usia paruh baya merupakan usia penuh tantangan sekaligus usia pencapaian puncak prestasi. Beberapa masalah yang dihadapi pa- sangan usia paruh baya seperti, pertengkaran suami istri, kenakalan anak, dan perdebatan siapa yang harus berperan di luar rumah sering mi tahui peran pasangan usia paruh baya dalam meningkatkan resiliensi keluarga, dan (2) mengetahui faktor-faktor protektif yang mempe- ngaruhi resiliensi keluarga pada pasangan usia paruh baya. Tulisan ini menggunakan pendekatan Kualitatif dengan jenis penelitian Studi Kasus. Teknik pengumpulan data menggunakan wawancara. Analisis datanya menggunakan langkah-langkah: (1) pengumpulan data (2) reduksi data, (3) penyajian data, dan (4) penarikan kesimpulan. Hasil penelitian ini adalah: (1) peran pasangan usia paruh baya dalam meningkatkan resiliensi keluarga adalah: a) bertanggungjawab atas ketenangan, keselamatan, dan kesejahteraan keluarga; b) men didik anak dengan penuh rasa kasih sayang dan tanggung jawab; c) memberi kebebasan berpikir dan bertindak kepada istri sesuai dengan ajaran agama; dan d) penghubung intern keluarga dengan masyarakat atau dunia luar; (2) faktor-faktor protektif yang turut mempengaruhi peningkatan resiliensi keluarga adalah sebagai berikut: a). faktor internal, meliputi: pengamalan nilai-nilai agama, adanya komitmen, saling percaya, dan adanya komunikasi; dan b) faktor eksternal, meliputi: orang tua, santri, kepercayaan dari masyarakat, asisten rumah tangga, teman, dan kyai. kali mengakibatkan perceraian bagi pasangan yang tidak me- liki resiliensi keluarga. Tulisan ini bertujuan untuk: (1) mengetahui peran pasangan usia paruh baya dalam meningkatkan resiliensi keluarga, dan (2) mengetahui faktor-faktor protektif yang mempe- ngaruhi resiliensi keluarga pada pasangan usia paruh baya. Tulisan ini menggunakan pendekatan Kualitatif dengan jenis penelitian Studi Kasus. Teknik pengumpulan data menggunakan wawancara. Analisis datanya menggunakan langkah-langkah: (1) pengumpulan data (2) reduksi data, (3) penyajian data, dan (4) penarikan kesimpulan. Hasil penelitian ini adalah: (1) peran pasangan usia paruh baya dalam meningkatkan resiliensi keluarga adalah: a) bertanggungjawab atas ketenangan, keselamatan, dan kesejahteraan keluarga; b) men didik anak dengan penuh rasa kasih sayang dan tanggung jawab; c) memberi kebebasan berpikir dan bertindak kepada istri sesuai dengan ajaran agama; dan d) penghubung intern keluarga dengan masyarakat atau dunia luar; (2) faktor-faktor protektif yang turut mempengaruhi peningkatan resiliensi keluarga adalah sebagai berikut: a). faktor internal, meliputi: pengamalan nilai-nilai agama, adanya komitmen, saling percaya, dan adanya komunikasi; dan b) faktor eksternal, meliputi: orang tua, santri, kepercayaan dari masyarakat, asisten rumah tangga, teman, dan kyai.
A New Matrix/Fracture Multiscale Coupled Model for Flow in Shale-Gas Reservoirs
Authors: Le Tien Dung , Murad Márcio A. , Pereira Patrícia A.
Published: June 2016

A new computational model for coupled gas flow in hydraulic fractures and multiporosity shale matrix is developed within the framework of multiscale modeling. The hydrodynamics in the network of hydraulic fractures are constructed by averaging the mass-conservation equation across the fracture aperture, giving rise to an averaged balance law supplemented by a source term arising from the jump in the gas flux from the shale matrix. The resultant flow equation in the fracture is coupled with a new pressure equation that governs the averaged gas movement in the shale matrix. Such a pressure equation exhibits a new storage coefficient and is rigorously derived by homogenizing the pore-scale model of gas flow in the interparticle pores, partially saturated with water, lying adjacent to the nanopores within the kerogen and impermeable inorganic matter composed of a reactive clay and an inert solid. The free gas at the interparticle pores is assumed at local thermodynamic equilibrium with the dissolved gas in the water and adsorbed gas lying in the nanopores of the kerogen aggregates and at the surface of the active clay. The constitutive laws for the partition coefficients, which appear in the pressure equation, are derived from the adsorption isotherms, which are rigorously constructed from the thermodynamics of confined gases on the basis of the density-functional-theory (DFT) approach. Numerical simulations of both canonical and real computational examples of gas primary recovery in the Barnett, Marcellus, and Eagle Ford formations illustrate the potential of the multiscale approach proposed herein in computing production in different flow regimes.
Ribonucleases with Antiproliferative Properties: Molecular Biological and Biochemical Characteristics
Authors: Pokrovskii Vadim Sergeevich , Treshchalina E.M. , Andronova N.V. , Deev S.M.
Published: June 2016

The article dwells on ribonucleases (RNAses) whose cytotoxic activity depends on the enzymatic activity, i.e. the ability to catalyze the cleavage of phosphodiester bonds of RNA. It presents both well-known information and our own data on RNAses of different origins with antitumor properties; it investigates the relation between the mechanism of cytotoxicity and biochemical and molecular biological characteristics. The analysis of published data demonstrates that all above characteristics contribute to the antiproliferative activity of RNAses. The major challenge for this group of enzymes is the achieving of selective bioavailability. This problem can be solved by creating conjugates as in case with ranpirnase and barnase. Based on their major pharmacological properties, active antitumor RNAses have great perspectives for treatment of not only oncohematological, but also solid malignancies.
Soluble Guanylyl Cyclase (sGC) in Mechanisms of Hypotensive and Antiaggregatory Effects Induced by Teraphtal (TP, sodium salt 4,5-cardoxyphtalQcyanin-cobalt)
Authors: Sidorova Tat'yana Aleksandrovna , Pyatakova N.V. , Severina I.S. , Kaliya O.L. , Gerasimova G.K.
Published: June 2016

Background & Aims. Many antitumor drugs produces not only the variety of therapeutic effects but also a broad spectrum of side effects, including acute hemodynamic dysfunctions (hypotension/hypertension, coagulation disorders). The aim of the paper is to investigate the role of soluble guanylyl cyclase (sGC) in mechanisms of hypotensive and antiaggregatory effects induced by teraphtal (TP) under experimental conditions in the clinic. Methods. The effect of different products on the basal activity of sGC isolated from platelets of human peripheral blood was assessed by the immunoenzyme method based on production of cyclic guanosine monophosphate (cGMP). The effect of TP on ADP-induced human platelet aggregation was evaluated by the turbidimetric Born method using an aggregometer. Results. In the presence of TP, the basal sGC activity increased by the average of 2.5-fold. The TP-induced dose-response curve of sGC activation displays a bell-shaped behavior with maximal stimulation effect achieved at a concentration of 1 μmol/L. TP does not affect the sGC activation induced by known sGC regulators, such as sodium nitroprusside (SNP) and YC-1. On the other hand, after preliminary incubation of sGC with TP, the ability of YC-1 to potentiate the enzyme stimulation induced by SNP decreased by about 33 %. In vitro tests demonstrated the ability of TP to inhibit the ADP-induced platelet aggregation and established the IC50 value for TP (15 μmol/L). Conclusion. TP is a direct sGC activator and therefore is able to participate in regulation of the NO→sGC→cGMP signaling pathway that controls the basal vascular tone and aggregatory platelet properties. Taking into account the TP characteristics, the paper discusses the involvement of additional mechanisms in the development of hypotension and hemostatic disorders induced by the drug.
Results of Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Acute Myeloid Leukemia with t(8;21)(q22;q22)/RUNX1-RUNX1T1 and Additional Cytogenetic Abnormalities
Authors: Gindina Tat'yana Leonidovna , Mamaev N.N. , Bondarenko S.N. , Nikolaeva E.S. , Slesarchuk O.A. , Borovkova A.S. , Paina O.V. , Razumova S.V. , Alyanskii A.L. , Zubarovskaya L.S. , Afanas'ev B.V.
Published: June 2016

Aim. To evaluate the impact of additional chromosomal aberrations on outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients with acute myeloid leukemia (AML) with t(8;21)(q22;q22)/RUNX1-RUNX1T1 translocation. Methods. Twenty-five AML patients with t(8;21)(q22;q22)/ RUNX1-RUNX1T1 translocation (10 women and 15 men, aged from 2 to 58 years; median 20.2) were examined. Analysis of overall (OS) and event-free survival (EFS) predictors after allo-HSCT in patients with different clinical, transplant and cytogenetic characteristics was performed. Results. The additional cytogenetic abnormalities were found in 13 (52 %) patients before the transplantation, at that, complex karyotype with three or more chromosomal abnormalities were registered in 9 (69 %) patients. The univariate analysis showed that OS and EFS after allo-HSCT differed in patients with different characteristics such as age (p = 0.03; p = 0.0006), clinical status at transplantation (p = 0.0002; p = 0,006), donor type (p = 0.0003; p = 0.002), the interval from diagnosis of leukemia to allo-HSCT (p = 0,008, for OS only), additional cytogenetic abnormalities (p = 0.03; p = 0.009) and complex karyotype (p = 0.004; p = 0.0003), respectively. In multivariate analysis, independent predictors of OS were donor type (p = 0.01), the interval from diagnosis of leukemia to allo-HSCT (p = 0.01), and additional cytogenetic abnormalities in karyotype (p = 0.04), as well as donor type (p = 0.04) and patient’s age (p = 0.004) for EFS. Conclusion. AML with t(8;21)(q22;q22)/RUNX1-RUNX1T1 translocation is a heterogeneous disease. The prognosis in patients with the additional cytogenetic abnormalities, especially in those with the complex karyotype, is worse both after the standard chemotherapy (i.e. before allo-HSCT), and after allo-HSCT.
Role of Patient's Age and Comorbidities in Therapy of Chronic Lymphocytic Leukemia
Authors: Strugov Vladimir Vladimirovich , Stadnik E.A. , Virts Yu.V. , Silina T.O. , Zaritskii A.Yu.
Published: June 2016

Background & Aims. New schemes of the antitumor therapy of CLL resulted in improvement of survival of relatively young patients. However, the therapy outcomes of elderly patients are still unsatisfactory. Erroneous overestimation of expected toxicity of standard therapeutic regimens in some elderly patients may play a certain role, thus leading to prescription of less effective regimens. Therefore, the urgent problem is to find objective criteria for risk stratification in CLL. The aim of the study is to evaluate the prognostic significance of patient's age and the CIRS-G index in elderly patients treated with fludarabine-containing regimens in first line treatment outside clinical trials. Methods. A retrospective analysis of 90 elderly CLL patients, treated with standard FC and FCR regimens in the clinic of internal medicine of the First St. Petersburg State Medical University from 2001 till 2011. The age median was 59 years (range from 43 to 78 years). The comorbidity index was determined for each patient using the CIRS-G score. Results. The overall response rate did not significantly differ between FC and FCR groups and was equal to 81.6 % and 93.4 %, respectively (p = 0.109). Complete remissions were achieved in 72.3 % of FCR group patients and only in 46.5 % of FC group patients (p = 0.018). The retrospective analysis of treatment tolerability in primary elderly patients with different CIRS-G scores in the routine clinical practice demonstrated that the index has no independent prognostic significance. Among all CIRS-G components (14 organs and systems), only renal and hepatic diseases demonstrated significant correlation with the overall survival rate (p < 0.001 and p = 0.028, respectively). Conclusion. The creatinine clearance value in the beginning of treatment is the most important predictor of FC and FCR regimen efficacy in elderly patients. The use of the comorbidity index with a 6-score threshold as a contraindication for fludarabine-containing regimens proved to be unjustified.
Role of Defects of Hematopoietic and Lymphoid Niches in Genesis of Chronic Lymphocytic Leukemia
Authors: Semenova N.Yu. , Bessmeltsev S.S. , Rugal V.I.
Published: June 2016

Background & Aims. Niche-forming elements of the bone marrow and lymphoid organs play an important role in the pathogenesis of chronic lymphocytic leukemias. The aim is to determine multifunctional characteristics of stromal elements of the hematopoietic and lymphoid microenvironment involved in formation of a niche of hematopoietic stem cells and lymphoid precursor cells. Methods. Histological specimens of the bone marrow and lymph nodes of 112 CLL patients (64 men and 48 women) were investigated. 45 patients were included in the combined analysis group. The age median was 60 years. 50 volunteers were included in the control group: trepanobiopsy of the iliac area was performed in 30 healthy subjects, and lymph node biopsy was performed in 20 patients with reactive lymphadenopathy. Standard staining (hematoxylin-eosin, azure-II-eosin, silver impregnation, Masson stain) was used for histological studies. The immunohistochemical analysis was performed using the primary antibody panel and the polymer visualization system Dako according to staining protocol. Results. While analyzing 96 trepanobioptates, we isolated three types of bone marrow infiltration: nodular (18.8 %, n = 18), interstitial (27 %, n = 26) and diffuse (54.2 %, n = 52). Nodular and interstitial bone marrow infiltrations reflect a more favorable course of CLL as compared to the diffuse type. The morphological characteristics of the bone marrow stroma of CLL patients may be caused by both primary impairment of the hematopoietic microenvironment, and cytokine disbalance resulting from the effect on the stroma of the leukemic clone. The morphological examination of lymph node bioptate of CLL patients demonstrated impairment of histoarchitectonics of lymphoid tissue elements in all cases. In lymph nodes of CLL patients, we demonstrated the increased number of small vessels on the background of decreased expression of extracellular matrix protein expression: IV type collagen, laminin, and desmin. Disintegration of lymph node follicular dendritic cells network was demonstrated. Conclusion. Examination of the nature of the effect of stroma on hematopoiesis remains an urgent hematological problem. In order to solve the problem of regulatory influence, the use of morphological methods is recommended, including the immunohistochemical analysis.
Evaluation of Nitrogen Fertilizer and Cultivation Methods for Agronomic Performance of Rice
Authors: Mi Wenhai , Yang Xin , Wu Lianghuan , Ma Qingxu , Liu Yanling , Zhang Xuan
Published: June 2016

Nitrogen fertilization and cultivation methods are the two principal management approaches used in agronomy to determine the growth and grain yield of rice. In this study, a field experiment was conducted to evaluate the performance of three cultivation methods (conventional manual transplanting of field‐grown seedlings [TFS], direct seeding [DS], and transplantation of glasshouse‐grown seedlings followed by manual transplanting [TGS]) under two N management treatments (split applications of urea [PU] vs. a single basal application of a controlled‐release fertilizer [CRF]) for growing rice under a subtropical monsoon climate in China (2011–2014). Annual grain yield, yield components, and total biomass were determined at maturity over the 4‐yr experiment. We also measured the dry matter, leaf area index, leaf area duration, and leaf chlorophyll “greenness” of rice at key growth stages. Over the 4 yr, the comparative grain yield of CRF significantly exceeded that of PU with TFS and TGS by 7.7 and 5.2%, respectively, suggesting that CRF was best for transplanted rice. In the case of DS, however, CRF reduced grain yield by 3% compared with PU. The grain yields of TFS and TGS were significantly higher than that of DS rice (by 8.2 and 11.6%, respectively) under the PU treatment and were higher under the CRF treatment (by 20 and 21%, respectively). Our results suggest that these two transplanting methods, when coupled to controlled‐release fertilizer management, could be an effective way to achieve higher rice grain yields.

Core Ideas

Controlled‐release fertilizer increased the grain yield compared with urea for transplanting rice.

Split applications of urea produced more grain yield than controlled‐release fertilizer for direct seeding rice.

Conventional manual transplanting of field‐grown seedlings and glasshouse‐grown seedlings followed by manual transplanting produced higher grain yield than direct seeding, irrespective of how N was managed.
Evaluating photo-degradation of COD and TOC in petroleum refinery wastewater by using TiO2/ZnO photo-catalyst
Authors: Aljuboury Dheeaa al deen Atallah , Palaniandy Puganeshwary , Abdul Aziz Hamidi Bin , Feroz Shaik , Abu Amr Salem S.
Published: June 2016

The aim of this study is to investigate the performance of combined solar photo-catalyst of titanium oxide/zinc oxide (TiO2/ZnO) with aeration processes to treat petroleum wastewater. Central composite design with response surface methodology was used to evaluate the relationships between operating variables for TiO2 dosage, ZnO dosage, air flow, pH, and reaction time to identify the optimum operating conditions. Quadratic models for chemical oxygen demand (COD) and total organic carbon (TOC) removals prove to be significant with low probabilities (<0.0001). The obtained optimum conditions included a reaction time of 170 min, TiO2 dosage (0.5 g/L), ZnO dosage (0.54 g/L), air flow (4.3 L/min), and pH 6.8 COD and TOC removal rates of 99% and 74%, respectively. The TOC and COD removal rates correspond well with the predicted models. The maximum removal rate for TOC and COD was 99.3% and 76%, respectively at optimum operational conditions of TiO2 dosage (0.5 g/L), ZnO dosage (0.54 g/L), air flow (4.3 L/min), reaction time (170 min) and pH (6.8). The new treatment process achieved higher degradation efficiencies for TOC and COD and reduced the treatment time comparing with other related processes.
Adsorption of heavy metals from aqueous solutions by Mg–Al–Zn mingled oxides adsorbent
Authors: El-Sayed Mona , Eshaq Gh. , ElMetwally A. E.
Published: June 2016

In our study, Mg–Al–Zn mingled oxides were prepared by the co-precipitation method. The structure, composition, morphology and thermal stability of the synthesized Mg–Al–Zn mingled oxides were analyzed by powder X-ray diffraction, Fourier transform infrared spectrometry, N2 physisorption, scanning electron microscopy, differential scanning calorimetry and thermogravimetry. Batch experiments were performed to study the adsorption behavior of cobalt(II) and nickel(II) as a function of pH, contact time, initial metal ion concentration, and adsorbent dose. The maximum adsorption capacity of Mg–Al–Zn mingled oxides for cobalt and nickel metal ions was 116.7 mg g−1, and 70.4 mg g−1, respectively. The experimental data were analyzed using pseudo-first- and pseudo-second-order kinetic models in linear and nonlinear regression analysis. The kinetic studies showed that the adsorption process could be described by the pseudo-second-order kinetic model. Experimental equilibrium data were well represented by Langmuir and Freundlich isotherm models. Also, the maximum monolayer capacity, qmax, obtained was 113.8 mg g−1, and 79.4 mg g−1 for Co(II), and Ni(II), respectively. Our results showed that Mg–Al–Zn mingled oxides can be used as an efficient adsorbent material for removal of heavy metals from industrial wastewater samples.
Web-forum as a speech genre of electronic communication
Authors: Miheeva Yuliya Aleksandrovna
Published: June 2016

The paper determines web-forum as a speech genre in terms of virtual communication discovering the peculiarities of this genre in course of analyzing its major genre features. The author considers web-forum to be a modern genre and a member of electronic communication hierarchy.
Corporate pension fund: the world practice of pension funds’ investment
Authors: Aleksandrova Anastasiya Alekseevna
Published: June 2016

Basing on the reports of leading consulting corporations and sustainable investment forums, the article makes an attempt to define the place of corporate pension funds in the global pension market. In particular, the role of the government regulations in the process of pension funds’ investment is revealed. Moreover, there is an emphasis on socially responsible investment policy of corporate pension funds as the most promising direction of development that contributes to the improvement of standard of living.
Ecology criteria as an important concept for emotive lingvoecology
Authors: Tarasova Olga Dmitrievna
Published: June 2016

The article deals with a new linguistic research area – emotive lingvoecology and an important concept for its research – ecology criteria. The author outlines some problems in the concise defining of this category and expands on each of its features. Emotions, emotion nominees and cross-cultural differences of English and Russian are in the focus of attention.
The semantics of «lacuna modifications» (a case study for the verbs of sound)
Authors: Ivlieva Irina Valentinovna
Published: June 2016

The article examines the insufficiently explored domain of Russian verbal word formation synthesis – the lacuna (gap) field. For the first time ever, the term «lacuna (gap) modification» is being introduced into linguistic usage. This new term is defined, the well-grounded classification of lacuna types is presented, and the methods for creating an adequate lexicographic index of lacunas (gaps) is provided. Using the methods of componential analysis and synthesis, the lacuna charts and diagrams for the verbs of sound are constructed. Data obtained from the Russian native speakers’ questionnaire is used for clarification purposes. The results of the research set forward the identification methodology and consistent description techniques for lacunas (gaps) with respect to their future codification in various dictionaries, e.g., thesaurus, word-formation, etc.
Analysis of "green economy" phenomenon and tools of environment quality management: a case study for the Republic of Belarus
Authors: Rybak Viktor Aleksandrovich , Grib Anna , Shokr Ahmad
Published: June 2016

The article carries out an analytical review of different approaches to defining the “green economy” phenomenon. The main fields and ways of using this term are described. The existing environmental management tools (environmental impact assessment, certification, auditing and the best available techniques) do not allow to evaluate environmental compatibility of projects and technologies, and are not able to specify the ways of their optimization. The authors suggest estimates of non-wastes, specific consumption, ecological and economical effectiveness, land capacity. The efficiency of reducing their values to a single integral component was proved in the article.
Culture and social interaction
Authors: Sevryugina Nadezhda Ivanovna
Published: June 2016

The article considers the concepts of culture and social interaction. The author outlines the impact of culture on people and discusses how social interaction changes the world.
The impact of noise disturbances on the quality of signal processing in the acoustic sodar
Authors: Laptev Maksim Vladimirovich
Published: June 2016

The article describes how noise impacts the work of vertical profilers (SODAR). The authors analyzed the types of noise disturbances, their features. The dependence of the error value from the signal/noise ratio, which is the main indicator of the quality of the acoustic locator. The authors showed that noise disturbances affect the accuracy of acoustic measurements significantly. Moreover, the article contains a brief summary based on the research.
Correlation and regression analysis of indicators of nuclear power plants efficiency of the Russian Federation
Authors: Debryanskaya Elena Anatolyevna
Published: June 2016

The article is devoted to a model construction, which shows how the volume of electricity production by nuclear power stations depend on the power of these stations. The authors demonstrate correlation and regression analysis, evaluate the statistical significance of the model.
Enzimas Extracelulares de Solos de Cerrado como Bioindicadores de Qualidade em Áreas Agricultáveis em Goiás, Brasil
Authors: Zago Leciana De Menezes Sousa , Oliveira Rogério Nunes , Bombonatto Anne Kethlen Gonçalves , Moreira Letícia Mikaelly De Oliveira , Melo Erik Nelson De Paiva , Caramori Samantha Salomão
Published: June 2016

A conversão de áreas nativas de Cerrado para a implantação de lavouras altera as propriedades físico-químicas e bioquímicas do solo. Neste estudo buscou-se compreender o efeito da sazonalidade do tipo de manejo utilizado para plantio de cana-de-açúcar sobre a atividade de hidrolases e oxirredutases. Amostras de solo de Cerrado nativo e solos convertidos a lavouras de cana-de-açúcar sob diferentes tipos de manejo foram submetidos a avaliações físico-química, biológica e bioquímica. A implantação de monoculturas no Cerrado provocou reduções na quantidade de matéria orgânica e carbono orgânico em relação ao Cerrado nativo, o que por sua vez refletiu em menor atividade biológica do solo. Dessa forma, foi possível constatar que hidrolases e oxidorredutases são sensíveis a variações ocasionadas por eventos de seca versus chuva, e também em função do tipo de cobertura vegetal e tipo de manejo utilizado para implantação de cultura agrícola de cana e, portanto, podem ser utilizadas como bioindicadores de qualidade em solos de Cerrado goiano.