bluuebunny/crossref_metadata_2025 huggingface dataset:
Therapeutic Monitoring of Antiretroviral Drugs in Immunologically Stable HIV Patients on ART Treatment
Authors: Panchagiri Sabitha , Valupadas Chandrasekhar , Ciddi Veeresham
Published: September 2024

In HIV, highly active anti-retroviral therapy helps patients to regain the immune CD4+ cell count. Among all antiretroviral therapy (ART) regimens tenofovir based regimen (TLE; Tenofovir (TDF) + Lamivudine (3TC) + Efavirenz (EFV)) has become the most preferred first line regimen. Present study aimed to identify the therapeutic levels of drugs in tenofovir based regimen in immunologically stable HIV patients. A total of 35 dried blood samples were obtained from HIV patients on TLE treatment visiting ART centre, Mahatma Gandhi Memorial (MGM) Hospital, Warangal, Telangana, during September 2017 to March 2018. Patients with good adherence, without history of smoking & alcoholism and with CD4+ cell count > 350 cells/mm3 were included. Estimation of drugs was done using pre validated liquid chromatographic method. In total of 35 patients, females were accounted for 62.86%. Patients of this study showed high percentage of illiterates (48.57%) and daily labors (34.29%). As EFV is a narrow therapeutic index drug it showed significant difference in its plasma therapeutic levels (0.005**) whereas TDF & 3TC were not. Total of 8.57% and 91.43% patients were showed EFV plasma levels below and above therapeutic levels respectively. Though the study patients observed with good immunological status, high percentage of patients identified with toxic levels of EFV concentrations. But none of the patients showed any symptoms of toxicity, they are at risk to develop clinical toxicity in future. Present study results suggesting dose adjustments and monitoring of drug levels in these patients to avoid early treatment failures and toxicity.
Keywords: HIV, CD4+ cell count, Tenofovir regimen, Therapeutic level, Monitoring.
A Review on Traditional Ayurveda Formulations and their Therapeutic Importance
Authors: Motghare Komal P. , Yeokar Vaibhav
Published: September 2024

Ayurveda the therapeutic system of Indian medicine utilizes various types of dosage forms for health benefits including Vati, Churna, Kwatha, Asava, Arishta, Kalka and Avaleha, etc. The different formulations possess different Virya (potency) therefore they act in different way. Ayurveda specified uses of various formulation for different health benefits and some formulation meant for specified uses through different route of administration like; oral, topical and nasal formulations, etc. Ayurveda also recommended use of various formulations with in specified age group say for example Bhasma not very popular in children. The availability of large number of formulation options not only enhances patient compliance but also increases physician choices. The liquid, solid, semisolid and Dhupan (smoke) are some ayurveda drug formulations based on their appearance, these all formulations having their specific characteristics differ from each other. Present article explored the concept and importance of diversified ayurveda formulations used for various therapeutic purposes.
Keywords: Ayurveda, formulations, dosage forms, Virya.
Enhancing Drug Delivery Systems: Pegylated Drug delivery and Nanoparticle Aided Drug Delivery
Authors: He Wentian
Published: September 2024

See PDf
Simultaneous estimation of atazanavir and ritonavir in combined Tablet dosage form: A Review
Authors: Kanade Akash Shankar , Bhagat Vishwas , Shete Rajkumar V.
Published: September 2024

In present study describe the development of new method and parameter which will be considered during method development and validation. Article give brief idea for a simple, sensitive, precise and accurate High-performance thin-layer chromatographic method for simultaneous determination of Ritonavir and Atazanavir in their combined tablet dosage form has been developed, validated and used for determination of the compounds in commercial pharmaceutical products. Chromatographic separation will be achieved on different column like C8, C18, etc. used as the stationary phase and different mobile phase.
Keywords: High-performance thin-layer chromatography, Ritonavir, Atazanavir
Nanoparticle in Pharmaceutical Drug Delivery System: A Review
Authors: Saokar Shivani , Saudagar Ravindranath
Published: September 2024

The most emerging branch in pharmaceutical sciences is “nanotechnology.” Nanopharmaceuticals comprised of nano- sized products which can be transformed in numerous ways to improve their characteristics. Nanoparticles reveal enormous potential in tissue engineering, carriers in drug delivery, understanding of basic biological processes, imaging, sensing, disease diagnostics and therapeutics. Application of nontechnology in drug delivery and medicine has paved new pathways and opened many doors for providing customizable and safer treatment option. There are significant advantages of nanoparticles which make them more potential and effective than the conventional drug delivery system in terms of high stability, high specificity, high drug carrying capacity,ability for targeted release, controlled delivery, possibility to use in different route of administration and the capability to deliver both hydrophilic and hydrophobic drug molecules, site specific targeting. Nanomaterials like polymeric nanoparticles, magnetic nanoparticles, liposomes, carbon nanotubes, quantum dots, dendrimers, metallic nanoparticles, polymeric nanoparticles, etc. have brought about revolutionary changes in drug delivery systems and in many other fields. So that, through the manipulation of molecular size and surface properties, researchers are able to deliver drugs for longer period of time with less frequent dosing and with greater precision and penetration in difficult to access tissues.The present chapter summarizes the types of nanopharmaceuticals with the properties, characterization and methods of preparation, advantages, and applications of nanoparticles in pharmaceutical and medical sector.
Keywords: Nanotechnology, Nanoparticles, Preparation, Characterization, Applications.
Free Radical Scavenging Potential of Mentha arvensis of South Gujarat: Evidence from In-vitro Assay
Authors: Kharat Amol R , Zakerab Farooqui , Kharat Kiran Ramesh
Published: September 2024

Present work was undertaken to evaluate efficacy of aqueous and methanol extracts Mentha arvensis leaves as free radical scavenger. The free radical scavenging activity was evaluated by nitric oxide scavenging method, hydrogen peroxide scavenging method and ferric thiocyanate method. The result of the studies was compared with the standard solution of Ascorbic Acid (Vitamin C) treated with same reagent. The results of all the studies showed significant free radical scavenging activity in both aqueous and methanolic extracts of Mentha arvensis and methanolic extract showed the highest free radical scavenging potential than aqueous extract.
Keywords: Free radical, Mentha arvensis, Nitric oxide, Hydrogen peroxide, ferric thiocyanate
Evaluation of prescription pattern and compliance in kashmiri women with polycystic ovarian syndrome
Authors: Rashid Rumaisa , Geer Mohamad Ishaq , Verma Santosh Kumar , Rashid Fouzia , Ganaie Ashraf
Published: September 2024

Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine system disorder affecting women of reproductive age. As there are a few studies with inconsistent data available in the literature regarding the prescription pattern and compliance of drugs in patients with PCOS, both within and outside India, the present study was undertaken to generate some valid and useful data regarding these parameters.
Objective: Evaluation of drug utilization and assessment of prescribing patterns and patient compliance among Kashmiri women with polycystic ovary syndrome.
Materials and Methods: This study was a prospective, observational and cross-sectional study, which was carried out on Kashmiri females diagnosed with PCOS as per Rotterdam criteria of 2003. Patients attending Srinagar based hospitals and clinics over a period of nine months. Information was collected through personal interviews using a pre-validated, self-administered data collection tool. The prescribing patterns of drugs were evaluated by comparison with Endocrine Society Clinical Practice Guidelines. Patient compliance with prescribed medicines was assessed using modified Morisky 8-Item Medication Adherence Questionnaire.
Results: Drugs prescribed to the study patients included oral contraceptive pills (OCPs) 57(46.34%), insulin sensitizers 75 (60.97%), anti-androgen 37 (30.08%), anti-estrogens 1 (0.81%), progestins 10 (8.13%), dopaminergic agonists 7 (5.69%), steroids 2 (1.62%) and statins 1(0.81%). 50 (40.65%) patients were highly adherent to their prescribed medications. Conclusion: The study revealed that nature of drugs prescribed to the study population was in consonance with the established standard guidelines. Most of the women were highly adherent to their prescribed medications.
Keywords: PCOS, prescription, drug adherence.
The Enhancement of solubility and dissolution rate of saxagliptine hydrochloride by solid dispersion technique
Authors: Ghule Krushna Bhiva , Dhobale Shankar M. , Kedar Vikas D. , Jadhav Suresh L.
Published: September 2024

Saxagliptine hydrochloride, PEG, polaxamer-407,ethyl cellulose were prepared to study the dissolution of sparingly water soluble Saxagliptine hydrochloride drug. solid dispersion of Saxagliptine hydrochloride were prepared using different ratios of PEG 6000 & Polaxamer-407.Some of the practical aspects to be considered for the preparation of solid dispersion such as selection of polymers ,methods of preparation solubility of drug and dissolution study of drug in solid dispersion are also discussed. The present research provides a there is increase in solubility of Saxagliptine hydrochloride and also solid dispersion complex of drug was giving better  dissolution profile as compared to other solid dispersions this imporove bioavailability. FT-IR , shows the compatability of drug & carrier.
Keywords- solid dispersion, solubility enhancement, dissolution rate
Role of Quality Assurance Department in Pharmaceutical Industries: A Review
Authors: Saudagar Ravindranath , Doltade Mayuri
Published: September 2024

The overview of the Quality Assurance Department in Pharmaceutical Industry is well discussed. It explains the vital role and the objectives of Quality Assurance Department. It also explains on how Quality Assurance can increase the revenue of the industry and how it is related to the other department as an important factor. This review gives the information about the role of Higher management and Importance of Quality Assurance in Pharmaceutical industry. It gives clear idea on how Quality Assurance Department works. The role of the Quality Assurance in Validation, Regulatory Affairs, and also in Business Development is explained. 
Keywords: Quality Assurance, Regulatory Affairs, Objective, Importance, GMP.
Isolation and Characterization of Tamarind Kernel Gum: A Novel Natural Floating Polymer
Authors: Santosh Kumar Rada , Chandana S.
Published: September 2024

Floating drug delivery systems (FDDS) are aimed to retain the drug in the stomach and are useful for drugs that are poorly soluble or unstable in intestinal fluids. The underlying principle is very simple i.e., to make the dosage form less dense than the gastric fluids so that it can float on them. The drug usually keeps floating in the gastric fluid and slowly dissolves at a pre-determined rate to release the drug from the dosage form and maintain constant drug levels in the blood. Several approaches are currently used to retain the dosage form in the stomach. The principle of the floating tablets is simple and practically approach to achieve increased gastric residence time to obtain controlled release. The polymers play an important role in the formulation of floating drug delivery systems as they should make the dosage form less dense and able to release the drug from the dosage form in a controlled manner. Though, there are several floating polymers available in the market, there is continuous need to develop floating polymers which are safe and inexpensive. The aim of the work was to isolate and characterize the Tamarind kernel gum as novel floating polymer.
Keywords: Floating Polymer, Controlled release, Tamarind Kernel Gum.
Preparation and Evaluation of Diltiazem Hydrochloride Controlled Release Matrix Tablets Employing Aegle marmelos Gum: A Novel Natural Controlled Release Polymer
Authors: Santosh Kumar Rada , Pratibhanusha Ch.
Published: September 2024

Oral Drug Delivery is considered as the holy grail of drug delivery due to its convenience which resulted in high patient compliance. Of all the drug delivery systems that have been explored, oral drug delivery is the most preferred option for systemic delivery of drug via various pharmaceutical products of different dosage forms. The advantage of administering a single dose of drug which is released over an extended period of time, instead of administering numerous doses, is now a day’s area of interest for formulation scientists in the pharmaceutical industry. For this reason, the conventional dosage forms of drugs are rapidly being replaced by the new and the novel drug delivery systems. Amongst these, the controlled release dosage forms have gradually gained medical acceptance and became extremely popular in modern therapeutics. The aim of the present work is to isolate Aegle marmelos gum and use it as a controlled release polymer in the formulation of diltiazem hydrochloride controlled release tablets.
Keywords: Isolation, Controlled release, Aegle marmelos Gum.
Proclamatation, Pacifism and Resistance
Authors: Harvey Barry
Published: September 2024

For there to be a clear and convincing project of social and political transformation, people need to be for something, not simply against what they deplore, but the ability to imagine viable alternatives. It is necessary to imagine a future that makes resistance worthwhile, but that ability is lacking because we humans have forgotten who we are. Dietrich Bonhoeffer contends that the primary task for theology is to understand the world better than it understands itself, from the gospel and from Christ. At the heart of the gospel is the Sermon on the Mount, which he summarizes as “the proclamation of the incarnate love of God” that “calls people to love one another, and thus to reject everything that hinders fulfilling this task,” foremost among which is the failure to love one’s enemies and renounce violence. Together proclamation and pacificism provide the basis for a political theology for the church: the recapitulation of all creation in the life, death, and resurrection of Christ. Bonhoeffer emphasizes the role of imagination to sustain meaningful resistance to evil, and he connects links the church’s current lack of imagination to the loss of moral memory. The traits that humans need to flourish—justice, truth, and beauty in particular—require the time and steadfastness that are only cultivated within a living moral memory.
Antifouling activity of marine bacterial extracts: A non-toxic alternative as biocide
Authors: Rico-Virgen Erika Guadalupe , Ortiz-Aguirre Ismael , Hellio Claire , Rangel-Dávalos Carlos , Escobedo-Fregoso Anahí , López-Fuerte Francisco Omar , Lora-Vilchis María Concepción , Aguila-Ramírez Ruth Noemí
Published: September 2024

Biofouling is generated by the biochemical condition of the substrate to form complex communities; this could be negative at an ecological and industrial level. To inhibit this process, coatings based on heavy metals are used. Microorganisms are promising sources of antifouling compounds that are non-toxic or less toxic than the commercial chemicals in use today. In order to evaluate the antifouling effectiveness of bacterial extracts, seven crude extracts from cultures of bacteria isolated from marine organisms were obtained. They were subjected to a toxicity test with Artemia nauplii, at different concentrations. Non-toxic extracts were incorporated into a gelling agent (Phytagel™) and exposed to the sea for 30 days to evaluate the inhibition of diatoms and macroorganisms adhesion. Sixty-seven diatoms’ taxa were identified, belonging to 45 genera, besides four groups of non-photosynthetic macroorganisms were identified; these are sea squirts, barnacles, bryozoans, and polychaetes. Toxicity test showed that only Bacillus safensis (C2) extract was toxic, and it was excluded from subsequent tests. There are significant differences between treatments, the extracts with the best activity are Shewanella algae (18) and Staphylococcus aureus (28). These extracts contain different organic compounds such as saponins, terpenes, sterols, and proteins, which could be responsible for their activity. These results suggest that microorganisms are an effective alternative to replace harmful chemical substances currently used in antifouling coatings. The extracts, being less toxic, are potential inhibitors or retardants of the epibiotic colonization process.
Lafaz Kebahagiaan dalam Tafsir Al-Azhar
Authors: Savira Anggy
Published: September 2024

One of the hopes and goals that humans want to achieve is happiness. This can be seen from the fact that humans try their best to achieve happiness in their lives. In the Qur'an happiness is expressed through various sentences and statements that express joy, pleasure, victory which is the foundation of human hope in life. The word that means happiness in the Qur'an is mentioned using several words, such as the word falāḥ, fawzan, fariḥa with various variations of each word. The purpose of the research is to find out the definition of happiness in the Qur'an, the lafaẓ expression of happiness in the Qur'an using Tafsir al-Azhar. The form of this research is library research using the Maudhu'i method. The data source in this study uses primary data, namely the book of Tafsir al-Azhar. The results showed that the meaning of happiness in Arabic is called sa'adah, which is taken from the root word sa'ada which means good and happy, found in QS. Hud: 105 and 108. Then lafaẓ which means happiness are: sa'adah, falāḥ, fawzan and fariḥa. HAMKA's interpretation in the book Tafsir al-Azhar is related to the lafaz of happiness in the verse: QS. Hud/11: 108, QS. Hajj/22: 77, QS. Al-Mu'minūn/23: 1, QS. al-A'la/87: 14, QS. Al-Shams/91: 9, QS. Al-Imran/3: 130 and 200, QS. Al-Tawbah/9: 88, QS. Al-Maidah/5: 35 dan 90, QS. Yunus/10: 64 dan QS. Hud/11: 10.
Abstrak: Salah satu harapan dan tujuan yang ingin dicapai manusia adalah kebahagiaan. Hal ini terlihat dari kenyataan yang menunjukkan bahwa manusia berusaha sekuat tenaga untuk mencapai kebahagiaan dalam hidupnya. Dalam al-Qur’an kebahagiaan diungkapkan melalui berbagai kalimat dan pernyataan yang mengungkapkan kegembiraan, kesenangan, kemenangan yang merupakan tumpuan harapan manusia dalam kehidupannya. Di dalam al-Qur’an kebahagiaan disebutkan dengan menggunakan beberapa kata yang bervariasi seperti kata falāḥ, fawzan,  dan fariḥa. Tujuan penelitian adalah untuk mengetahui definisi kebahagiaan dalam al-Qur’an, ungkapan lafaẓ kebahagiaan dalam al-Qur’an dengan menggunakan Tafsir al-Azhar. Bentuk Penelitian ini adalah penelitian kepustakaan (library research) dengan menggunakan metode Maudhu’i. Sumber data dalam penelitian ini menggunakan data sekunder yaitu kitab Tafsir al-Azhar. Adapun hasil penelitian menunjukkan bahwa makna kebahagiaan dalam bahasa Arab disebut sa‘adah, yang diambil dari akar kata sa‘ada yang artinya adalah kebaikan dan bahagia, terdapat dalam QS. Hud: 105 dan 108. Kemudian lafaẓ yang semakna dengan kebahagiaan adalah: sa’adah, falāḥ, fawzan dan fariḥa. Penafsiran HAMKA dalam kitab Tafsir al-Azhar terkait dengan lafaz kebahagiaan pada ayat: QS. Hud/11: 108, QS. Hajj/22: 77, QS. Al-Mu’minūn/23: 1, QS. al-A’la/87: 14, QS. Al-Syams/91: 9, QS. Ali-Imran/3: 130 dan 200, QS. Al-Tawbah/9: 88, QS. Al-Maidah/5: 35 dan 90, QS. Yunus/10: 64 dan QS. Hud/11: 10.
Pemahaman Ayat-ayat Dakwah Perspektif Jamaah Tabligh di Masjid Jamik Bukit Baro Montasik
Authors: Wusqa Urwatul
Published: September 2024

Jamaah Tabligh is a missionary group that employs specific methods of proselytization, namely Khurūj fī Sabīlillāh (going out in the path of Allah) and Jaulah (building connections by visiting homes). These methods are not commonly found in general missionary activities, raising questions about Jamaah Tabligh’s understanding of the verses related to proselytization and their impact on society. In order to address these questions, this research focuses on field studies. Based on the conducted research, it has been found that in Surah Āli ‘Imrān verse 110, they interpret “ukhrijat” as going out in the path of Allah, referring to the Khurūj fī Sabīlillāh method of proselytization. Furthermore, in the context of enjoining good and forbidding evil, they understand that forbidding evil is a result of enjoining good. Additionally, in Surah al-Ḥajj verse 78, they equate jihad with Khurūj fī Sabīlillāh, drawing parallels between the sacrifice involved in both, such as the use of personal wealth and temporarily leaving family and employment. In conclusion, there is a difference in understanding between Jamaah Tabligh and the interpretations put forth by traditional commentators.
Jamaah Tabligh merupakan suatu kelompok dakwah yang memiliki metode-metode dakwah khusus, yaitu Khurūj fī Sabīlillāh (keluar di jalan Allah) dan Jaulah (silaturahmi dengan mendatangi rumah-rumah). Metode ini tidak ditemukan dalam dakwah-dakwah yang dilakukan secara umum. Sehingga memunculkan persoalan bagaimana pemahaman Jamaah Tabligh tentang ayat-ayat dakwah serta dampaknya bagi masyarakat. Untuk menjawab persoalan tersebut, maka penelitian ini difokuskan pada kajian lapangan (field research). Berdasarkan penelitian yang sudah dilakukan, ditemukan bahwa: Pada Surah Āli ‘Imrān ayat 110, mereka mengartikan “ukhrijat” sebagai keluar di jalan Allah, yaitu metode dakwah Khurūj fī Sabīlillāh. Kemudian pada anjuran amal makruf nahi mungkar, mereka memahami bahwa nahi mungkar merupakan hasil dari amal makruf. Selanjutnya pada Surah al-Ḥajj ayat 78, mereka menyamakan jihad dengan Khurūj fī Sabīlillāh, karena adanya kesamaan pengorbanan dengan jihad, seperti menggunakan harta pribadi serta meninggalkan keluarga dan pekerjaan dalam kurun waktu tertentu. Dapat disimpulkan bahwa terdapat perbedaan pemahaman antara Jamaah Tabligh dengan apa yang telah dicetuskan oleh para mufasir.
A representação da mulher executiva na revista Exame
Authors:   , Ribeiro Juliana Aline Fungaro
Published: September 2024

Esta dissertação se desenvolve no âmbito do Programa de Pós-Graduação em Comunicação e Cultura, na linha de pesquisa Mídia e Práticas Socioculturais, e tem como tema a representação da mulher executiva na revista Exame, por meio de levantamento de reportagens sobre mulher, publicadas na revista eletrônica, durante o período de 2018 a 2021. Busca-se responder o seguinte problema de pesquisa: Como a mulher executiva é representada na Revista Exame? O objetivo é investigar como o gênero feminino é representado no mundo empresarial. Para tanto, foi feito um breve panorama do movimento feminista através dos conceitos de Garcia (2011), Alves & Pitanguy (1991), Pinto (2003) e de representação social e tecnologia de gênero nos conceitos de Hall (2016) e Lauretis (1987). Lipovetsky (2000) auxilia sobre a perspectiva histórica da inserção da mulher no trabalho, junto com Perrot (2009), Saffiotti (2013). Com o propósito de se alcançar os objetivos, adota-se a análise de conteúdo de Bardin (2010) e Franco (2005) como a metodologia desse estudo. Neste trabalho, o objeto de pesquisa é “mulher”, vamos entendê-la no senso comum. A presença da mulher neste contexto tem um campo importante de pesquisa, e a representação dela no cargo de poder ainda reproduz estereótipos preconceituosos, colocando obstáculos à mulher para alcançá-lo. A relevância desse trabalho está em propiciar reflexões acerca de como a mulher está sendo representada nas revistas de negócios e o seu papel no mundo do trabalho. As análises dos recortes das revistas selecionadas possibilitam relacionar o lugar das mulheres em importantes cenários no mundo empresarial. Elas estão, cada vez mais, em destaque em novos postos de trabalho, buscando os cargos de liderança. Neste trabalho, analisamos 11 reportagens da Revista Exame, e elas mostraram que em algumas profissões as mulheres já ultrapassaram os homens. Entretanto, em pleno século XXI, nos cargos de liderança, elas ainda enfrentam o preconceito por serem mulher também se tiverem filhos. As mulheres são guerreiras e buscam a ruptura do “teto de vidro” e do estereótipo que são frágeis.
Reflexiones sobre educación matemática desde la etnomatemática
Authors: Londoño Agudelo Ivonne Amparo , Rosa Milton , Orey Daniel Clark , Aroca Araújo Armando , Blanco Álvarez Hilbert , Vásquez Hernández Ana Patricia , Molano-Franco Edwin Yesid , Rodríguez Ramírez Juan Gabriel , Giongo Ieda Maria , Quartieri Marli Teresinha , Hepp Rehfeldt Márcia Jussara , Parra Sánchez Aldo Iván
Published: September 2024

En la actualidad, existe un creciente interés en la comunidad de educadores matemáticos por los aspectos sociales, culturales y políticos de la Educación Matemática. Este libro ofrece al lector una recopilación de resultados de investigaciones, proyectos y prácticas educativas que exploran diversas posibilidades de investigación y trabajo en el aula desde la perspectiva de la Etnomatemática. Por un lado, se presenta a los maestros en formación inicial una visión de las matemáticas como una producción humana y social, donde el conocimiento matemático se integra como parte de la diversidad cultural de los pueblos. Se enfatiza en unas matemáticas inclusivas para todos y todas, donde se fomenta el protagonismo como productores de conocimiento matemático y se promueven valores como el respeto a la diversidad de pensamientos, la dignidad, la inclusión social, la justicia y el diálogo intercultural. Por otro lado, se ofrece a los maestros en ejercicio herramientas para reflexionar sobre su propia práctica, basadas en aspectos matemáticos de su cultura. Se busca promover la enseñanza y el aprendizaje desde un enfoque situado, que reconozca y valore los contextos culturales y sociales en los cuales se desarrolla la educación matemática.
Możliwości produkcyjne rolnictwa a sytuacja żywnościowa świata
Authors: Babiak Jerzy
Published: September 2024

Głód stanowi obecnie jedno z największych niebezpieczeństw ludzkości. Zjawisko to jest groźne zarówno w wymiarze politycznym, ekonomicznym jak i humanitarnym. Możliwości produkcyjne rolnictwa przyjmują wyraźnie dwubiegunowy charakter. W krajach średnio i wysoko rozwiniętych rolnictwo jest w stanie nie tylko zaspokoić potrzeby żywnościowe swojej ludności, ale także wytworzyć ich nadwyżki. Natomiast na pokaźnych obszarach Ziemi (ok. 1 mld mieszkańców) występuje permanentne zjawisko braku żywności. Tą niekorzystną sytuację pogłębia w ostatnich latach wyraźny wzrost cen produktów żywnościowych. W największym stopniu odczuje to społeczność żyjąca w krajach biednych, nieustannie zagrożonych problemem głodu.
Dług publiczny i wzrost gospodarczy w krajach członkowskich Unii Europejskiej
Authors: Misztal Piotr
Published: September 2024

Podstawowym celem artykułu jest analiza związków między długiem publicznym i wzrostem gospodarczym w Unii Europejskiej w okresie 2000-2010. Artykuł składa się z dwóch części. Pierwsza cześć dotyczy analizy teoretycznej dotyczącej współzależności między długiem publicznym i wzrostem gospodarczym z uwzględnieniem przyczyn i czynników determinujących te zależności. W następnej części artykułu zbadano związek między długiem publicznym i wzrostem gospodarczym w UE przy pomocy modelu wektorowej autoregresji (VAR). Dokonano oszacowania współczynników elastyczności długu publicznego na zmiany PKB oraz współczynników elastyczności PKB na zmiany długu publicznego na podstawie funkcji odpowiedzi impulsowych. Następnie przeprowadzono dekompozycję wariancji długu publicznego i PKB w celu oszacowania wpływu tych czynników na zmienność odpowiednio PKB i długu publicznego.
Anisotropic nonlinear elliptic equations with variable exponents and two weighted first order terms
Authors: Naceri Mokhtar
Published: September 2024

This paper is devoted to studying the existence of distributional solutions
for a boundary value problems associated to a class of anisotropic nonlinear
elliptic equations with variable exponents characterized by two strictly
positive? ?W1, ??p(?)(?) first order terms (the weight functions belong to
the anisotropic variable exponents Sobolev space with zero boundary), and
this is in bounded open Lipschitz domain (with Lipschitz boundary) of RN (N
? 2). The functional setting involves anisotropic varible exponents
Lebesgue-Sobolev spaces.
On (B,C)-MP-inverses of rectangular matrices
Authors: Zhu Huihui , Yang Yuxuan
Published: September 2024

For any A ? Cn?m, the set of all n by m complex matrices, Mosic and
Stanimirovic [14] introduced the composite OMP inverse of A by its outer
inverse with the prescribed range, null space and Moore-Penrose inverse.
This inverse unifies the core inverse, DMP inverse and Moore-Penrose
inverse. In this paper, we mainly introduce and investigate a class of
generalized inverses in complex matrices. Also, it is proved that this
generalized inverse coincides with the OMP inverse. Finally, the defined
inverse is related to OMP-inverses, W-core inverses and (b, c)-core inverses
in the context of matrices.
Metallic shaped contact hypersurfaces of Kaehler manifolds
Authors: Özgür Cihan
Published: September 2024

We study on metallic shaped contact hypersurfaces of Kaehler manifolds. We
show that a metallic shaped (?,?)-contact metric hypersurface of a Kaehler
manifold has constant mean curvature. As a special case, we also consider
product shaped Sasakian hypersurfaces of Kaehler manifolds.
Efficacy observation of acupoint application combined with psychological intervention in elderly patients with mild liver-qi stagnation depression
Authors: Wang Zhaoling , Yu Liangzhong
Published: September 2024

Introduction/Objective. The objective was to propose a safer and more effective treatment method for mild liver-qi stagnation syndrome depression in elderly patients. Methods. A total of 70 elderly patients were recruited from the outpatient or inpatient departments of our hospital between July and December 2022 and were randomly divided into two groups, with 35 in each. The control group received sertraline, and the observation group received acupuncture point application combined with psychological intervention. The course of treatment was 10 days for four consecutive courses of treatment. Following courses 1, 2, and 4, the patients? Hamilton Depression Scale (HAMD-24) scores were compared. Statistical analysis was performed using the paired t-test and the ?2 test. Results. After the end of courses 1, 2, and 4, the traditional Chinese medicine syndrome scale and total HAMD-24 scores were lower in the observation group than in the control group (p < 0.01, p < 0.05). Conclusion. The acupoint application combined with psychological intervention has a rapid and significant effect and fewer adverse effects in liver-qi depression.
Dynamical analysis of a class of Monkeypox epidemic model
Authors: Liu Guyue , Li Huilai
Published: September 2024

In this paper, we proposed and investigated a class of Monkeypox infectious
mathematical model between human and animal populations, with a particular
focus on interventions targeting early-exposed population. The model
involves a more realistic incidence term and the possible stochastic
perturbations. We conducted a detailed mathematical analysis of the
corresponding deterministic model, including the existence of solutions to
the equations, the existence of equilibria, the basic reproduction number,
R0, and the local stability of equilibria. Then we turned to the stochastic
model, and obtained the sufficient conditions of the disease eradication and
sustained persistence of the stochastic system. Finally, we conducted
numerical simulations to validate the proposed models and validated that the
stochastic interaction is a crucial factor for studying the infectious
disease. The results indicated that the detection and intervention of
early-stage infected individuals have significant impact on the control of
the disease transmission.
Dynamic behaviors of the non-linear local fractional heat conduction equation on the cantor sets
Authors: Li Geng , Wang Kang-Jia
Published: September 2024

Based on the local fractional derivative, a fractal non-linear heat
conduction equation, which can model the behavior of the heat transfer in
the fractal medium, is extracted in this work. On defining the
Mittag-Leffler function on the Cantor sets, two special functions namely the
TH?(??) function and CH?(??) function are constructed, and then are employed
along with Yang?s non-differentiable transfor?mation seek for the
non-differentiable exact solutions. The obtained results confirm that the
proposed method iseffective and powerful, and can provide a promising way to
find the exact solutions of the fractal PDE.
Prevention and control of vacuum interval by managed pressure injection in cementing
Authors: Fu Jiasheng , Liu Wei , Han Xiaosong , Zhao Qing , Hao Weiwei , Li Ning
Published: September 2024

This article uses on-site drilling data and establishes a hydraulic model for
pres?sure-controlled cementing to simulate and analyze the generation
process of the vacuum interval in the wellbore, as well as the changes in
the volume and height of the vacuum interval, bottom hole pressure, and
point of interest pressure over time. This model can optimize and recommend
key parameters such as target wellhead back pressure and displacement based
on the pressure window and drilling param?eters, with the target pressure of
the focus point as the anchor point. Through the hydraulic model of
controlled pressure cementing, the hydraulic parameters and processes of
managed pressure cementing can be optimized and recommended, effectively
ensuring the safety of the cementing process.
Analysis of controlling factors for hydraulic fracturing parameters and accumulated production using machine learning
Authors: Zhu Zhihua , Hsu Maoya , Li Chang , Dai Jiacheng , Xie Bobo , Ma Zhengchao , Wang Tianyu , Li Jie , Tian Shouceng
Published: September 2024

This study, based on static data from over a thousand fracturing wells,
employs data governance, data mining, and machine learning regression
uncover princi?pal controlling factors for production in the fracturing
context. Utilizing multiple evaluation methods, the entropy weight method
comprehensively scores and ranks the principal controlling factors. A
machine learning production prediction model is established for validation.
Results show that DBSCAN achieves better accuracy in identifying field
anomaly data. For missing data, it is recommended to use tree models or
neural networks instead of imputation or constant filling, as incorrect
imputation significantly degrades model performance. The entropy weight
meth?od effectively integrates various correlation analysis results,
providing a better connection with production compared to other approaches.
This research utilizes large-scale field data to extract key parameters
affecting production, supporting the establishment of high precision
prediction models and the optimization of pa?rameters for unconventional
reservoir production forecasts.
An excellent scheme for the couple-Higgs equation
Authors: Wu Zi-Ge , Wei Chun-Fu
Published: September 2024

The couple-Higgs equation is an important non-linear evolution equation in
the field of physics. In this paper, the couple-Higgs equation is
investigated by employing the tanh function method, and the new solitary
wave solution is successfully constructed. Finally, the physical properties
of this solitary wave solution are elaborated by plotting the 3-D graphs
with proper parameters.
New perspective to disease and insect infection model
Authors: Zhu Qing , Wei Chun-Fu
Published: September 2024

The main purpose of this paper is to study a class of forest disease and
insect infection models with time delay. The exact solutions are
successfully obtained by using the homotopy perturbation method.
Prevalent Metformin Use in Adults with Diabetes and the Incidence of Long Covid: An EHR-based Cohort Study from the RECOVER Program
Authors: G. Johnson Steven , Abedian Sajjad , Stürmer Til , D. Huling Jared , Lewis V Colby , B Buse John , B Brosnahan Shari , C. Mudumbi Praveen , M. Erlandson Kristine , A McComsey Grace , Arnold Jonathan , D. Wiggen Talia , Wong Rachel , Murphy Shawn , Rosen Clifford , Kaushal Rainu , Weiner Mark G. , Bramante Carolyn
Published: September 2024

Objective: Studies show metformin use before and during SARS-CoV-2 infection reduces severe COVID-19 and post-acute sequelae of SARS-CoV-2 (PASC) in adults. Our objective was to describe the incidence of PASC and possible associations with prevalent metformin use in adults with T2DM. Research Design and Methods: This is a retrospective cohort analysis using N3C and PCORNet EHR databases with an active comparator design that examined metformin-exposed individuals vs non-metformin individuals on other diabetes medications. T2DM was defined by HbA1C>=6.5 or T2DM EHR diagnosis code. The outcome was death or PASC within 6 months, defined by EHR code or computable phenotype. Results: In the N3C, the hazard ratio (HR) for death or PASC-U09.9 was 0.79 (95% CI 0.71-0.88, p<0.001); and for death or PASC-N3C was 0.85 (95% CI 0.78-0.92, p<0.001). In PCORnet, the HR for death or PASC-U09.9 was 0.87 (95% CI 0.66-1.14, p= 0.08); and for death or PASC-PCORnet was 1.04 (95% CI 0.97-1.11, p=0.58). Incident PASC by diagnosis code was 1.6% metformin vs 2.0% comparator in the N3C; 2.1% metformin vs 2.5% comparator in PCORnet. By computable phenotype, incidence was 4.8% metformin and 5.2% comparator in the N3C; 24.7% metformin vs 26.1% comparator in PCORnet. Conclusions: Prevalent metformin use is associated with a slightly lower incidence of death or PASC after SARS-CoV-2 infection. PASC incidence by computable phenotype is higher than by EHR code, especially in PCORnet. These data are consistent with other observational analyses showing prevalent metformin is associated with favorable outcomes after SARS-CoV-2 infection in adults with T2DM.
Análisis de los softwares matemáticos en la enseñanza aprendizaje del cálculo diferencial en estudiantes de educación superior
Authors:   Instituto Superior Tecnológico Luis Tello, García Gruezo Rosario Alexandra , Criollo Flores José Manuel ,   Instituto Superior Tecnológico Luis Tello, Hurtado Becerra Steven David ,   Instituto Superior Tecnológico Luis Tello, Salazar Castillo Carlos ,   Instituto Superior Tecnológico Luis Tello
Published: September 2024

Las matemáticas como asignatura es un pilar importante por el enfoque en la comprensión lógica de las operaciones, esto ayuda a que los estudiantes alcancen un nivel más profundo de especialización y aplicarlo a la vida profesional. Es aquí donde el cálculo diferencial permite a los estudiantes del nivel superior puedan resolver diversos problemas matemáticos de límites, continuidad, derivaciones y sus aplicaciones. Para la revisión de los estudios científicos se utilizó diversos motores de búsqueda como: Google académico, ResearchGate, Scielo y Dialnet durante los últimos 5 años, de esta forma identificar un análisis exacto sobre diferentes softwares matemáticos que ofrece a docentes y estudiantes diversas opciones para mejorar la comprensión del cálculo diferencial para este nivel educativo, demostrando las múltiples ventajas que tienen los programas. De esta manera los docentes podrán elegir y aplicar algunas de estas herramientas educativas para reforzar el aprendizaje significativo del cálculo diferencial.
DADOS E RETRATOS DAS MASCULINIDADES NEGRAS NO BRASIL
Authors: Trindade Gésus de Almeida , Muniz Gardenia Oliveira
Published: September 2024

A discussão acerca das masculinidades negras está cada vez mais em pauta atualmente, sendo essencial refletir sobre os desafios e obstáculos que esse grupo enfrenta. Nesse sentido, o presente estudo procura analisar dados que destacam aspectos importantes das diferentes expressões das masculinidades negras em setores como educação, saúde e segurança pública. Os dados coletados neste estudo qualiquantitativo foram reunidos a partir da análise de pesquisas realizadas por organizações respeitáveis, como o Instituto Brasileiro de Geografia e Estatística (IBGE). Os resultados revelam que os principais desafios que se destacam para os homens negros no Brasil incluem a necessidade de superar as desigualdades educacionais, a garantia de acesso igualitário à saúde, a desconstrução de estereótipos e representações negativas, e a luta contínua contra o racismo estrutural e o extermino da juventude negra. Além disso, as perspectivas futuras exigem a implementação efetiva de políticas públicas que promovam a inclusão e o empoderamento, a ampliação do diálogo intercultural e a valorização das contribuições dos homens negros para a sociedade brasileira. Assim, a busca por equidade racial é um desafio complexo, porém fundamental para a construção de uma sociedade mais justa e plural.
DEVELOPMENT OF A MODEL OF A CYBER THREATS DETECTION SYSTEM WITH SUPPORT AND UPDATE OF ATTACK DETECTION RULES
Authors:   Lviv Polytechnic National University, Holdiy A. , Shpur O. , Masyuk A.
Published: September 2024

The article addresses the issue of data protection in information and communication systems amid the growing volume of traffic and the increasing number of cyber threats, necessitating improvements in the effectiveness of intrusion detection and prevention systems. Various types of Intrusion Detection Systems (IDS) and Intrusion Prevention Systems (IPS), their advantages, and disadvantages are considered. The methods of threat detection are analyzed, including signature-based methods, anomaly detection methods, and machine learning-based methods. Special attention is paid to methods of attack detection based on traffic content. The effectiveness of various commercial and open-source solutions, such as Snort and Suricata, is compared in terms of their architecture, performance, and accuracy. The main proposal is to enhance the Suricata system with an additional module called the Intelligent Threat Detector (ITD), which is based on machine learning methods. The ITD module is integrated into the main Suricata module and performs deep traffic analysis and anomaly detection. This approach helps reduce the load on the detection system, improving the processing performance of incoming traffic and ensuring a high level of security. The proposed solution provides a multi-level approach to network protection, where initial filtering is carried out by Suricata, and deep analysis is performed by ITD. The system can intercept network packets for information analysis, building processing functions based on selected data to determine the possibility of intrusion. Additionally, the integration of the ITD module allows the system to adapt to new and unknown threats in real time, as the module continuously learns from new data, ensuring continuous improvement in detection accuracy and response to threats. Placing the system behind the firewall helps reduce the load on the detection system, ensuring efficient use of multiprocessor system resources and reducing false positives.
Pengaruh Variabel Makroekonomi dan Indikator Rasio Keuangan Terhadap Profitabilitas Bank Umum Konvensional di Indonesia
Authors: Yola Elvi , Satrianto Alpon
Published: September 2024

Banks are part of the financial system which plays an important role in a countrys economic development. This research will examine the influence of economic growth, inflation, Non Performing Loan (NPL), Net Interest Margin (NIM), and Operating Cost of Operating Income (BOPO) on Profitability as measured by Return on Asset (ROA). This study uses quarterly time series data from 2005-2022. This results of this study indicate that the macroeconomic variables, namely economic growth, have a negative and significant effect on profitability, and inflation has no significant effect on profitability. While the financial ratio indicator NPL has a negetive and significant effect on profitability, while NIM has a positive and significant effect on profitability, and BOPO has a negetive ang significant effect on profitability. The effect of these variable on profitability is expected to encourage an upward trend in profitability.
Digitalizácia v prostredí miestnych samospráv, súčasnosť a výzvy do budúcnosti
Authors: Ľapinová Erika , Kubišová Martina
Published: September 2024

The topic of digitization resonates in Slovakia and around the world, both in the corporate and public sectors. It is a natural result of technical, economic, and social development at home and in the world with significant economic, social, and individual-level impacts. Both Slovakia and the European Union have set strategic goals in this area and are interested to fulfilling them. In our paper, we present the topic of digitalization to the widest possible range of readers, because, especially from the professional public, there are voices about the lack of information on the issue. We define it against related concepts as computerization (electronization), smart cities, and industry 4.0. In the article, we aim to focus on digitalization in the environment of local governments, we present selected examples of possible digital solutions from self-government practice, but we also reflect on the challenges and barriers that currently hinder the application of digital solutions in the practice of local governments to support in this way the implementation of digital solutions in practice, and also to point out the importance of further research in this sphere and outline its further direction.
Postoje spotrebiteľov k spoločenskej zodpovednosti v bankovom sektore
Authors: Bartošová Simona , Fulajtárová Zlatica , Gvorová Adriána , Štofanová Veronika
Published: September 2024

Today, socially responsible businesses are gaining popularity because of their long-term benefits to consumers, businesses, and society. Corporate social responsibility can be seen as a commitment to improving the public good through voluntary business practices and using corporate resources. The company must fulfill such a social function. The main objective of the paper is to identify the importance of individual banking activities in the context of CSR from the customer's point of view and then to examine the CSR activities in the selected bank. In our contribution, we present two types of research: primary consumer research and the second qualitative corporate research from secondary sources conducted at a specific bank. The responses indicate that corporate social responsibility and its implementation by banks have a significant impact on consumers' perception of the bank and on building a competitive advantage in the marketplace.