bluuebunny/crossref_metadata_2025 huggingface dataset:
The Role of Digital Technology in Curbing COVID-19
Authors: Alghamdi Noha S. , Alghamdi Saeed M.
Published: July 2022

Introduction: Using digital technology to provide support, medical consultations, healthcare services, and to track the spread of the coronavirus has been identified as an important solution to curb the transmission of the virus. This research paper aims to (1) summarize the digital technologies used during the COVID-19 pandemic to mitigate the transmission of the COVID-19; (2) establish the extent to which digital technology applications have facilitated mitigation of the spread of COVID-19; and (3) explore the facilitators and barriers that impact the usability of digital technologies throughout the pandemic. Methods: A rapid electronic search following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines was conducted of available records up to June 2022 on the medical databases PubMed, Ovid, Embase, CINHAIL, the Cochrane Library, Web of Science, and Google Scholar. Results: An increasing number and variety of digital health applications have been available throughout the pandemic, such as telehealth, smartphone mobile health apps, machine learning, and artificial intelligence. Each technology has played a particular role in curbing COVID-19 transmission. Different users have gained benefits from using digital technology during the COVID-19 pandemic and different determinants have contributed to accelerating the wheel of digital technology implementation during the pandemic. Conclusion: Digital health during the COVID-19 pandemic has evolved very rapidly, with different applications and roles aimed at curbing the pandemic.
Study on the Enhanced Remediation of Petroleum-Contaminated Soil by Biochar/g-C3N4 Composites
Authors: Lin Hongyang , Yang Yang , Shang Zhenxiao , Li Qiuhong , Niu Xiaoyin , Ma Yanfei , Liu Aiju
Published: July 2022

This work developed an environmentally-friendly soil remediation method based on BC and g-C3N4, and demonstrated the technical feasibility of remediating petroleum-contaminated soil with biochar/graphite carbon nitride (BC/g-C3N4). The synthesis of BC/g-C3N4 composites was used for the removal of TPH in soil via adsorption and photocatalysis. BC, g-C3N4, and BC/g-C3N4 have been characterized by scanning electron microscopy (SEM), Brunauer–Emmett–Teller surface area analyzer (BET), FT-IR, and X-ray diffraction (XRD). BC/g-C3N4 facilitates the degradation due to reducing recombination and better electron-hole pair separation. BC, g-C3N4, and BC/g-C3N4 were tested for their adsorption and photocatalytic degradation capacities. Excellent and promising results are brought out by an apparent synergism between adsorption and photocatalysis. The optimum doping ratio of 1:3 between BC and g-C3N4 was determined by single-factor experiments. The removal rate of total petroleum hydrocarbons (TPH) by BC/g-C3N4 reached 54.5% by adding BC/g-C3N4 at a dosing rate of 0.08 g/g in a neutral soil with 10% moisture content, which was 2.12 and 1.95 times of BC and g-C3N4, respectively. The removal process of TPH by BC/g-C3N4 conformed to the pseudo-second-order kinetic model. In addition, the removal rates of different petroleum components in soil were analyzed in terms of gas chromatography–mass spectrometry (GC-MS), and the removal rates of nC13-nC35 were above 90% with the contaminated soil treated by BC/g-C3N4. The radical scavenger experiments indicated that superoxide radical played the major role in the photocatalytic degradation of TPH. This work definitely demonstrates that the BC/g-C3N4 composites have great potential for application in the remediation of organic pollutant contaminated soil.
Pulmonary Capacity, Blood Composition and Metabolism among Coal Mine Workers in High- and Low-Altitude Aboveground and Underground Workplaces
Authors: Wang Yi , Wang Hongchu , Chen Yinru , Xu Naxin , Lee Winson , Lam Wing-Kai
Published: July 2022

(1) Background: While previous studies revealed how underground mining might adversely affect the cardiopulmonary functions of workers, this study further investigated the differences between under- and aboveground mining at both high and low altitudes, which has received little attention in the literature. (2) Methods: Seventy-one healthy male coal mine workers were recruited, who had worked at least 5 years at the mining sites located above the ground at high (>3900 m; n = 19) and low (<120 m; n = 16) altitudes as well as under the ground at high (n = 20) and low (n = 16) altitudes. Participants’ heart rates, pulmonary functions, total energy expenditure and metabolism were measured over a 5-consecutive-day session at health clinics. (3) Results: Combining the results for both above- and underground locations, workers at high-altitude mining sites had significantly higher peak heart rate (HR), minimum average HR and training impulse as well as energy expenditure due to all substances and due to fat than those at low-altitude sites. They also had significantly higher uric acid, total cholesterol, creatine kinase and N-osteocalcin in their blood samples than the workers at low-altitude mining sites. At underground worksites, the participants working at high-altitude had a significantly higher average respiratory rate than those at low-altitude regions. (4) Conclusion: In addition to underground mining, attention should be paid to high-altitude mining as working under a hypoxia condition at such altitude likely presents physiological challenges.
Torso Shape Improves the Prediction of Body Fat Magnitude and Distribution
Authors: Choppin Simon , Bullas Alice , Thelwell Michael
Published: July 2022

Background: As obesity increases throughout the developed world, concern for the health of the population rises. Obesity increases the risk of metabolic syndrome, a cluster of conditions associated with type-2 diabetes. Correctly identifying individuals at risk from metabolic syndrome is vital to ensure interventions and treatments can be prescribed as soon as possible. Traditional anthropometrics have some success in this, particularly waist circumference. However, body size is limited when trying to account for a diverse range of ages, body types and ethnicities. We have assessed whether measures of torso shape (from 3D body scans) can improve the performance of models predicting the magnitude and distribution of body fat. Methods: From 93 male participants (age 43.1 ± 7.4) we captured anthropometrics and torso shape using a 3D scanner, body fat volume using an air displacement plethysmography device (BODPOD®) and body fat distribution using bioelectric impedance analysis. Results: Predictive models containing torso shape had an increased adjusted R2 and lower mean square error when predicting body fat magnitude and distribution. Conclusions: Torso shape improves the performance of anthropometric predictive models, an important component of identifying metabolic syndrome risk. Future work must focus on fast, low-cost methods of capturing the shape of the body.
BmCDK5 Affects Cell Proliferation and Cytoskeleton Morphology by Interacting with BmCNN in Bombyx mori
Authors: Wei Yi , Zhou Xiaolin , Chen Peng , Jiang Xia , Jiang Ziyi , Dong Zhanqi , Pan Minhui , Lu Cheng
Published: July 2022

The ordered cell cycle is important to the proliferation and differentiation of living organisms. Cyclin-dependent kinases (CDKs) perform regulatory functions in different phases of the cell cycle process to ensure order. We identified a homologous gene of the Cyclin-dependent kinase family, BmCDK5, in Bombyx mori. BmCDK5 contains the STKc_CDK5 domain. The BmCDK5 gene was highly expressed in S phase. Overexpression of the BmCDK5 gene accelerates the process of the cell cycle’s mitotic period (M) and promotes cell proliferation; knocking out the BmCDK5 gene inhibited cell proliferation. Furthermore, we identified a protein, BmCNN, which can interact with BmCDK5 and represents the same express patterns as the BmCDK5 gene in the cell cycle phase and the spatial-temporal expression of B. mori. This study revealed that BmCDK5 and BmCNN play roles in promoting cell proliferation and regulating cytoskeleton morphology, but do not induce expression changes in microtubule protein. Therefore, our findings provide a new insight; the BmCDK5 gene has a regulatory effect on the cell cycle and proliferation of B. mori, which is presumably due to the interaction between BmCDK5 and BmCNN regulating changes in the cytoskeleton.
Use of Dexpanthenol for Atopic Dermatitis—Benefits and Recommendations Based on Current Evidence
Authors: Cho Yoon Sun , Kim Hye One , Woo Seung Man , Lee Dong Hun
Published: July 2022

Background: Atopic dermatitis (AD) is an inflammatory skin disease of multiple phenotypes and endotypes, and is highly prevalent in children. Many people of all ages, including active adolescents, pregnant women, and the elderly, suffer from AD, experiencing chronicity, flares, and unexpected relapse. Dexpanthenol has multiple pharmacological effects and has been employed to treat various skin disorders such as AD. We aimed to summarize the up-to-date evidence relating to dexpanthenol and to provide a consensus on how to use dexpanthenol effectively for the treatment of AD. Methods: The evidence to date on the application and efficacy of dexpanthenol in AD was reviewed. The literature search focused on dexpanthenol use and the improvement of skin barrier function, the prevention of acute flares, and its topical corticosteroid (TCS) sparing effects. Evidence and recommendations for special groups such as pregnant women, and the effects of dexpanthenol and emollient plus in maintenance therapy, were also summarized. Results: Dexpanthenol is effective and well-tolerated for the treatment of AD. Dexpanthenol improves skin barrier function, reduces acute and frequent flares, has a significant TCS sparing effect, and enhances wound healing for skin lesions. Conclusion: This review article provides helpful advice for clinicians and patients on the proper maintenance treatment of AD. Dexpanthenol, as an active ingredient in ointments or emollients, is suitable for the treatment and maintenance of AD. This paper will guide dermatologists and clinicians to consider dexpanthenol as a treatment option for mild to moderate AD.
Clinical and Molecular Characteristics of Diabetic Retinopathy and Its Severity Complications among Diabetic Patients: A Multicenter Cross-Sectional Study
Authors: Al Zabadi Hamzeh , Taha Ibrahim , Zagha Rami
Published: July 2022

Background: Diabetic retinopathy (DR) is a complication associated with uncontrolled DM. It is a leading preventable cause of visual impairment in the world and a cause of blindness in those under 75 years old in developing countries. We aimed to explore the prevalence and associated risk factors of DR among diabetic patients in the West Bank. Materials and Methods:A quantitative multicenter cross-sectional study was conducted in all West Bank cities. Nearly, 385 patients underwent a comprehensive eye examination in addition to blood and urine tests. A previously validated questionnaire for ocular examination classification was used together with a socio-demographic and past medical history information sheet. Results: The prevalence of all DR in the West Bank was 41.8%. The prevalence of non-proliferative diabetic retinopathy (NPDR) was 50.3% (38.5% for mild NPDR, 10.6% for moderate NPDR and 1.2% for severe NPDR). The prevalence of proliferative diabetic retinopathy (PDR) was 9.9% and 39.7% for diabetic macular edema (DME) (17.4% for mild, 15.5% for moderate and 6.8% for severe DME). The prevalence of vision-threatening PDR and DME was 49.7% for both. In a univariate analysis, DR was significantly associated with body mass index; BMI (p = 0.035), DM duration (p = 0.002), Low-density lipoprotein (LDL) (p = 0.034), glutamic-oxaloacetic transaminase (GOT) level (p = 0.016) andblood urea (BU) (p = 0.044). A multivariate analysis showed a strong significant association between DR andpatients who had DM for 10-19years (adjusted odds ratio; AOR (95%CI); 1.843 (1.05–3.22)), abnormal levels of LDL (AOR (95%CI); 0.50 (0.30–0.83)), abnormal levels of GOT (AOR (95%CI); 0.49 (0.27–0.89)), and overweight (AOR (95%CI); 0.39 (0.19–0.80)). Conclusions: We found that the prevalence of DR in Palestine was higher than the global prevalence. Referral coordination between ophthalmologists and internal physicians is necessary to better follow up with DR patients. An interventional educational program by clinicians and public health professionals is recommended.
Plasma Endothelial and Oxidative Stress Biomarkers Associated with Late Mortality in Hospitalized COVID-19 Patients
Authors: Orea-Tejada Arturo , Sánchez-Moreno Carlos , Aztatzi-Aguilar Octavio Gamaliel , Sierra-Vargas Martha Patricia , González-Islas Dulce , Debray-García Yazmín , Ortega-Romero Manolo Sibael , Keirns-Davis Candace , Cornejo-Cornejo Laura , Aguilar-Meza Jorge
Published: July 2022

Background: Coronavirus infectious disease 2019 (COVID-19) is a significant public health problem worldwide. COVID-19 increases the risk of non-pulmonary complications such as acute myocardial injury, renal failure, thromboembolic events, and multi-organic damage. Several studies have documented increased inflammation molecules, endothelial dysfunction biomarkers, and dysregulation of coagulation factors in COVID-19 patients. In addition, endothelium dysfunction is exacerbated by the oxidative stress (OxS) promoted by endocrine and cardiovascular molecules. Our objective was to evaluate whether endothelial and OxS biomarkers were associated with mortality in hospitalized COVID-19 patients. Methods: A prospective cohort study was performed. Patients ≥18 years old with confirmed COVID-19 that required hospitalization were included in a prospective cohort study. Endothelium and oxidative stress biomarkers were collected between 3 and 5 days after admission. Results: A total of 165 patients were evaluated; 56 patients succumbed. The median follow-up was 71 days [23–129]. Regarding endothelial dysfunction and OxS biomarkers, patients who did not survive had higher levels of nitrates (0.4564 [0.1817–0.6761] vs. 0.2817 [0.0517–0.5], p = 0.014), total nitrates (0.0507 [−0.0342–0.1809] vs. −0.0041 [−0.0887–0.0909], p = 0.016), sE-Selectin (1.095 [0.86–1.495] vs. 0.94 [0.71–1.19], p = 0.004), and malondialdehyde (MDA) (0.50 [0.26–0.72] vs. 0.36 [0.23–0.52], p = 0.010) compared to patients who survived. Endothelial and OxS biomarkers independently associated with mortality were sE-selectin (HR:2.54, CI95%; from 1.11 to 5.81, p = 0.027), nitrates (HR:4.92, CI95%; from 1.23 to 19.63, p = 0.024), and MDA (HR: 3.05, CI95%; from 1.14 to 8.15, p = 0.025). Conclusions: Endothelial dysfunction (sE-selectin and nitrates) and OxS (MDA) are independent indicators of a worse prognosis in COVID-19 patients requiring hospitalization.
PyPore3D: An Open Source Software Tool for Imaging Data Processing and Analysis of Porous and Multiphase Media
Authors: Aboulhassan Amal , Brun Francesco , Kourousias George , Lanzafame Gabriele , Voltolini Marco , Contillo Adriano , Mancini Lucia
Published: July 2022

In this work, we propose the software library PyPore3D, an open source solution for data processing of large 3D/4D tomographic data sets. PyPore3D is based on the Pore3D core library, developed thanks to the collaboration between Elettra Sincrotrone (Trieste) and the University of Trieste (Italy). The Pore3D core library is built with a distinction between the User Interface and the backend filtering, segmentation, morphological processing, skeletonisation and analysis functions. The current Pore3D version relies on the closed source IDL framework to call the backend functions and enables simple scripting procedures for streamlined data processing. PyPore3D addresses this limitation by proposing a full open source solution which provides Python wrappers to the the Pore3D C library functions. The PyPore3D library allows the users to fully use the Pore3D Core Library as an open source solution under Python and Jupyter Notebooks PyPore3D is both getting rid of all the intrinsic limitations of licensed platforms (e.g., closed source and export restrictions) and adding, when needed, the flexibility of being able to integrate scientific libraries available for Python (SciPy, TensorFlow, etc.).
Distribution and Bioaccumulation of Essential and Toxic Metals in Tissues of Thaila (Catla catla) from a Natural Lake, Pakistan and Its Possible Health Impact on Consumers
Authors: Saleem Muhammad , Iqbal Javed , Shi Zongbo , Garrett Scott H. , Shah Munir H.
Published: July 2022

Although fish are often recommended as a component of a healthy diet, the environmental accumulation of heavy metals in many fish species has been of considerable concern for those weighing the nutritional health benefits against adverse toxic outcome of excess intake of toxic metals. This study aimed to determine the concentration of essential and toxic metals in the tissues of Catla catla in Mangla Lake and to assess the possible risk to the consumers. Fifty samples of Catla catla were collected from Mangla Lake, Mirpur, Azad Jammu and Kashmir, Pakistan and analyzed for eighteen metals including essential and trace metals. The measured range concentrations (µg/g, wet weight) in muscle tissues, in decreasing order, were: K (955–1632), Ca (550–2081), Na (449–896), Mg (129–312), Zn (61.2–215), Fe (11.6–26.8), Sr (2.60–9.27), Pb (1.72–7.81), Se (1.55–3.55), Co (0.12–4.08), Mn (1.04–4.33), Ni (0.69–3.06), Cu (0.88–2.78), Cr (0.45–1.88), As (0.67–1.58), Cd (0.28–0.56), Hg (0.17–0.57) and Li (0.12–0.38). The metal concentrations found in this study were comparatively higher than those reported in literature. A majority of the metals exhibited higher accumulation in gills compared with those in scales and muscles. Mean levels of Pb, As, Co, Mn, Cd, Cr and Zn in Catla catla muscle were found to be exceeding the international permissible limits for the safe human consumption. The condition factor (K), as an indicator of fish health status, indicated that Catla catla of Mangla Lake are in good health condition. The metal pollution index (MPI) of gills (27.9), scales (12.5) and muscle (7.57) indicated low contamination. Moreover, human health risk was evaluated using estimated weekly intake (EWI) and daily intake (EDI), target hazard quotient (THQ), hazard index (HI) and target cancer risk (TCR). Estimated weekly and daily intake values for As, Cd, Cr, Hg, Ni and Pb were higher than provisional permissible tolerable weekly intake and permissible tolerable daily intake while THQ for As, Cd, Cr, Hg, Pb, Se and Zn was higher than 1. The THQ for As, Hg and Pb was several folds higher than 1, indicative of lifetime non-carcinogenic health risks to the consumers. The hazard index indicated cumulative risk, which greatly increased with increasing fish consumption. Target cancer risk indicated that the people eating the Catla catla from Mangla Lake were exposed to As, Cd, Cr, Ni and Pb with a significant lifetime carcinogenic risk. In summary, consumption of Catla catla from this lake was found to be associated with an increased lifetime risk to the general health of the consumers.
The Clinical and Psychosocial Outcomes for Women Who Received Unexpected Clinically Actionable Germline Information Identified through Research: An Exploratory Sequential Mixed-Methods Comparative Study
Authors: Forrest Laura E. , Forbes Shepherd Rowan , Tutty Erin , Pearce Angela , Campbell Ian , Devereux Lisa , Trainer Alison H. , James Paul A. , Young Mary-Anne
Published: July 2022

Background Research identifying and returning clinically actionable germline variants offer a new avenue of access to genetic information. The psychosocial and clinical outcomes for women who have received this ‘genome-first care’ delivering hereditary breast and ovarian cancer risk information outside of clinical genetics services are unknown. Methods: An exploratory sequential mixed-methods case-control study compared outcomes between women who did (cases; group 1) and did not (controls; group 2) receive clinically actionable genetic information from a research cohort in Victoria, Australia. Participants completed an online survey examining cancer risk perception and worry, and group 1 also completed distress and adaptation measures. Group 1 participants subsequently completed a semi structured interview. Results: Forty-five participants (group 1) and 96 (group 2) completed the online survey, and 31 group 1 participants were interviewed. There were no demographic differences between groups 1 and 2, although more of group 1 participants had children (p = 0.03). Group 1 reported significantly higher breast cancer risk perception (p < 0.001) compared to group 2, and higher cancer worry than group 2 (p < 0.001). Some group 1 participants described how receiving their genetic information heightened their cancer risk perception and exacerbated their cancer worry while waiting for risk-reducing surgery. Group 1 participants reported a MICRA mean score of 27.4 (SD 11.8, range 9–56; possible range 0–95), and an adaptation score of 2.9 (SD = 1.1). Conclusion: There were no adverse psychological outcomes amongst women who received clinically actionable germline information through a model of ‘genome-first’ care compared to those who did not. These findings support the return of clinically actionable research results to research participants.
Assessing the Outreach of Targeted Development Programmes—A Case Study from a South Indian Village
Authors: Reddy Anugu Amarender , Sarkar Anindita , Onishi Yumiko
Published: July 2022

This paper explores beneficiary targeting of government programmes in a village in India. The analysis is based on all 228 households of the village and focus group discussions. The results show that there is a large exclusion error in targeted programmes, which have mostly excluded the poor and the needy. Most schemes have a prerequisite of asset ownership, such as agricultural land, which benefits resource-rich farmers with large landholdings. The relationship between benefits received and income of households is best represented by an inverted ‘u’-shape curve, indicating the middle-income category benefits more than the poorest. The scope and scale of welfare programmes, especially Direct Benefit Transfers, increased during the COVID-19 pandemic. For inclusion of the poorest of the poor, welfare and development schemes need to be decoupled from landownership in rural areas.
DOM and Nominal Structure—Some Notes on DOM with Bare Nouns
Authors: Irimia Monica Alexandrina
Published: July 2022

Differential object marking (DOM) interacts with nominal structure in complex ways across Romance languages. For example, in Spanish, it has been claimed to ban bare nominals. For Romanian, in turn, two main restrictions have been discussed: (i) ban on overt definiteness on unmodified nominals; and (ii) ban on bare nominals, if the structure contains an overt modification. This paper has two main goals. First, it examines some contexts where these types of restrictions can be lifted for some speakers; such contexts allow us to grasp a better understanding of the limits of variation permitted by DOM in its interaction with nominal structure and determiner systems. Secondly, it proposes that a theory under which DOM signals a licensing strategy beyond Case can derive the variation patterns observed in the data. Subsequently, various parameters are examined, which encode (i) how specifications responsible for DOM interact with other features in the composition of nominals; and (ii) how the resulting complex containing DOM as well as other features is resolved at PF.
Cardio-Oncology Rehabilitation—Present and Future Perspectives
Authors: Elad Boaz , Habib Manhal , Caspi Oren
Published: July 2022

Recent advances in cancer therapy have led to increased survival rates for cancer patients, but also allowed cardiovascular complications to become increasingly evident, with more than 40% of cancer deaths now being attributed to cardiovascular diseases. Cardiotoxicity is the most concerning cardiovascular complication, one caused mainly due to anti-cancer drugs. Among the harmful mechanisms of these drugs are DNA damage, endothelial dysfunction, and oxidative stress. Cancer patients can suffer reduced cardiorespiratory fitness as a secondary effect of anti-cancer therapies, tumor burden, and deconditioning. In the general population, regular exercise can reduce the risk of cardiovascular morbidity, mortality, and cancer. Exercise-induced modifications of gene expression result in improvements of cardiovascular parameters and an increased general fitness, influencing telomere shortening, oxidative stress, vascular function, and DNA repair mechanisms. In cancer patients, exercise training is generally safe and well-tolerated; it is associated with a 10–15% improvement in cardiorespiratory fitness and can potentially counteract the adverse effects of anti-cancer therapy. It is well known that exercise programs can benefit patients with heart disease and cancer, but little research has been conducted with cardio-oncology patients. To date, there are a limited number of effective protective treatments for preventing or reversing cardiotoxicity caused by cancer therapy. Cardiac rehabilitation has the potential to mitigate cardiotoxicity based on the benefits already proven in populations suffering from either cancer or heart diseases. Additionally, the fact that cardiotoxic harm mechanisms coincide with similar mechanisms positively affected by cardiac rehabilitation makes cardiac rehabilitation an even more plausible option for cardio-oncology patients. Due to unstable functional capacity and fluctuating immunocompetence, these patients require specially tailored exercise programs designed collaboratively by cardiologists and oncologists. As the digital era is here, with the digital world and the medical world continuously intertwining, a remote, home-based cardio-oncology rehabilitation program may be a solution for this population.
Development of Doped Carbon Quantum Dot-Based Nanomaterials for Lubricant Additive Applications
Authors: Kumar Vijay Bhooshan , Sahu Amit Kumar , Rao Kota Bhanu Sankara
Published: July 2022

The development of advanced lubricants is essential for the pursuit of energy efficiency and sustainable development. In order to improve the properties of lubricating fluids, high-performance lubricating additives are required. In recent research studies, carbon nanomaterials such as fullerenes, carbon nanotubes, and graphene have been examined as lubricating additives to water or oil. Lubricating oils are well known for the presence of additives, especially friction-reducers and anti-wear additives. As part of this work, we have studied the advancement in the research and development of carbon dot (CD)-based lubricant additives by presenting a number of several applications of CD-based additives. We have also highlighted the friction-reducing properties and anti-wear properties of CDs and their lubrication mechanism along with some challenges and future perspectives of CDs as an additive. CDs are carbon nanomaterials that are synthesized from single-atom-thick sheets containing a large number of oxygen-containing functional groups; they have gained increasing attention as friction-reducing and antiwear additives. CDs have gradually been revealed to have exceptional tribological properties, particularly acting as additives to lubricating base oils. In our final section, we discuss the main challenges, future research directions, and a number of suggestions for a complete functionalized or hybrid doped CD-based material.
3-Phenyl-4-(prop-2-en-1-yl)-5-[(prop-2-en-1-yl)sulfanyl]-4H-1,2,4-triazole
Authors: Slyvka Yurii I. , Goreshnik Evgeny A. , Fedko Andrii M. , Mys’kiv Marian G.
Published: July 2022

1,2,4-Triazoles appear to be attractive substances due to their wide range of applications. Previously 3-phenyl-4-(prop-2-en-1-yl)-5-[(prop-2-en-1-yl)sulfanyl]-4H-1,2,4-triazole (Atr) has proven to be an effective precursor for us to prepare Cu(I)-π,σ-coordination compounds with nonlinear optical and magnetic properties. In this study, we present the structural characterization of Atr by a single-crystal X-ray diffraction method. The crystals are monoclinic, Sp.gr. P21, Z = 2, unit cell dimensions: a = 5.6967(3), b = 7.8045(3), c = 14.9327(7) Å, β = 91.113(4)°, V = 663.78(5) Å3 at 150 K. To analyze the intermolecular interactions in the crystal structure of Atr, a DFT computational study was also performed.
Intelligent Bearing Fault Diagnosis Based on Multivariate Symmetrized Dot Pattern and LEG Transformer
Authors: Pang Bin , Liang Jiaxun , Liu Han , Dong Jiahao , Xu Zhenli , Zhao Xin
Published: July 2022

Deep learning based on vibration signal image representation has proven to be effective for the intelligent fault diagnosis of bearings. However, previous studies have focused primarily on dealing with single-channel vibration signal processing, which cannot guarantee the integrity of fault feature information. To obtain more abundant fault feature information, this paper proposes a multivariate vibration data image representation method, named the multivariate symmetrized dot pattern (M-SDP), by combining multivariate variational mode decomposition (MVMD) with symmetrized dot pattern (SDP). In M-SDP, the vibration signals of multiple sensors are simultaneously decomposed by MVMD to obtain the dominant subcomponents with physical meanings. Subsequently, the dominant subcomponents are mapped to different angles of the SDP image to generate the M-SDP image. Finally, the parameters of M-SDP are automatically determined based on the normalized cross-correlation coefficient (NCC) to maximize the difference between different bearing states. Moreover, to improve the diagnosis accuracy and model generalization performance, this paper introduces the local-to-global (LG) attention block and locally enhanced positional encoding (LePE) mechanism into a Swin Transformer to propose the LEG Transformer method. Then, a novel intelligent bearing fault diagnosis method based on M-SDP and the LEG Transformer is developed. The proposed method is validated with two experimental datasets and compared with some other methods. The experimental results indicate that the M-SDP method has improved diagnostic accuracy and stability compared with the original SDP, and the proposed LEG Transformer outperforms the typical Swin Transformer in recognition rate and convergence speed.
Morphological and Viscoelastic Properties of the Cicada Tymbal
Authors: Fahrunnida  , Sayekti Puspa Restu , Robert Colin , Retnoaji Bambang , Alam Parvez
Published: July 2022

This paper focusses on the morphological and viscoelastic properties of the cicada tymbal from the species Dundubia rufivena. Morphological details were determined by scanning electron and fluorescence microscopy, while the viscoelastic properties were determined by dynamic mechanical thermal analysis, and further supported by differential scanning calorimetry. We find that water evaporation from the tymbal begins at 71.1 °C and the glass transition for the tymbal, which is a chitin–resilin composite, is on average 150 °C, though there is considerable heterogeneity in the material of the tymbal, as indicated by the half height peak width of the tymbal (35.3 °C) and the shoulder peak indicative of a second phase and hence glass transition at on average, 168 °C. This second phase is assumed to reflect the effects of large-scale molecular pinning and restructuring at resilin–chitin interfaces (possibly via specific binding domains). In addition, we elucidate that the predominantly resilin regions of the tymbal of Dundubia rufivena is reinforced by a polygonal mesh of chitin, a morphological feature that has not been described in any previous research on the cicada tymbal. We provide evidence for nonlinear elasticity in the tymbal by comparing the storage modulus of the tymbal at different frequencies and loading amplitudes.
Developing a Multicriteria Decision-Making Model Based on a Three-Layer Virtual Internet of Things Algorithm Model to Rank Players’ Value
Authors: Chang Che-Wei
Published: July 2022

This paper proposes a multicriteria decision-making model based on a three-layer virtual internet of things (IoT) algorithm to automatically track and evaluate professional football players’ performance over the Internet. The three layers were respectively related to (1) automated data reading, (2) the players’ comprehensive grey relational degree calculation, and (3) the players’ classification. The methodology was applied in the context of the COVID-19 pandemic to investigate the performance of the top 10 defenders (according to The Sun, an internationally renowned sports website) in the European leagues, participating in the knockout phase of the 2019–20 UEFA Champions League. The results indicate that Virgil van Dijk of Liverpool FC was the best defender, followed by Harry Maguire of Manchester United, and Sergio Ramos of Real Madrid in the second and third positions, respectively. However, this ranking contradicted that of The Sun’s, which ranked these defenders in the seventh, tenth, and eighth positions, respectively. These results can help club management, coaches, and teams negotiate price positioning and future contract renewals or player transfers.
Stationary Probability Density Analysis for the Randomly Forced Phytoplankton–Zooplankton Model with Correlated Colored Noises
Authors: Ma Yuanlin , Yu Xingwang
Published: July 2022

In this paper, we propose a stochastic phytoplankton–zooplankton model driven by correlated colored noises, which contains both anthropogenic and natural toxins. Using Khasminskii transformation and the stochastic averaging method, we first transform the original system into an Itô diffusion system. Afterwards, we derive the stationary probability density of the averaging amplitude equation by utilizing the corresponding Fokker–Planck–Kolmogorov equation. Then, the stability of the averaging amplitude is studied and the joint probability density of the original two-dimensional system is given. Finally, the theoretical results are verified by numerical simulations, and the effects of noise characteristics and toxins on system dynamics are further illustrated.
The Knowledge and Attitudes of Primary Care and the Barriers to Early Detection and Diagnosis of Alzheimer’s Disease
Authors: de Levante Raphael Donna
Published: July 2022

Primary care physicians play a vital role in the clinical care of their patients, early identification of dementia, and disease advocacy. It is essential to assess the knowledge and attitudes of physicians in the diagnosis of Alzheimer’s disease and other dementias. In primary care, the diagnosis of Alzheimer’s disease is often missed or delayed. With the increased prevalence of Alzheimer’s disease and the growing impact of dementia on health care resources, early detection by primary care physicians (PCP) is essential. Thus, their knowledge and attitudes about early detection and diagnosis are crucial. To examine the knowledge and attitudes of primary care physicians regarding early detection and diagnosis of Alzheimer’s disease and how barriers may contribute to missed and delayed detection and diagnosis. An interpretive scope review was used to synthesize and analyze a body of literature published over the past decade. The study population are physicians in the United States. The current health systems experience challenges in providing early, safe, accurate, and comprehensive Alzheimer’s diagnosis and care by a primary care physician trained or knowledgeable in diagnosing the various forms of dementia. This article identifies several interrelated obstacles to early detection and diagnosis in primary dementia care, including gaps in knowledge, attitudes, skills, and resources for person with dementia (PWD)/caregivers and their primary care providers and systematic and structural barriers that negatively impact dementia care. Research shows that Alzheimer’s disease has gone underdiagnosed and undertreated. Delays in detection, diagnosis, and resource utilization may have social and clinical implications for individuals affected by Alzheimer’s disease and their families, including challenges in obtaining an accurate diagnosis. Until the issues of missed and delayed Alzheimer’s screening become more compelling, efforts to promote early detection and diagnosis should focus on the education of physicians and removing the barriers to diagnosis.
Optimization of the Process Parameters of Laser Beam Powder Bed Fusion GTD222 Nickel-Based Superalloy Based on Two Laser Energy Densities
Authors: Wang Zhiqiang , He Bo , Song Zhenfeng , Lan Liang , Lu Guoxin , Gao Shuang
Published: July 2022

The effect of volume energy density and deposition energy density on the roughness, porosity, density and hardness of laser beam powder bed fusion (LBPBF) GTD222 Ni-based superalloy was systematically studied. The results showed that the roughness and porosity of the alloy decreased with the increase of the two laser energy densities, while the density and hardness increased. When the volume energy density and the deposition energy density exceeded a threshold value, the density and hardness reached the maximum value and almost remained constant. The volume energy density could be used to estimate the laser conditions for obtaining high-density LBPBF GTD222 alloy more accurately than the deposition energy density. The process parameters for the transformation of the alloy from porous to dense were determined based on the volume energy density. This study provides guidance for the optimization of the process parameters of LBPBF GTD222 alloy.
Crosstalk between Host Genome and Metabolome among People with HIV in South Africa
Authors: Liu Chang , Wang Zicheng , Hui Qin , Chiang Yiyun , Chen Junyu , Brijkumar Jaysingh , Edwards Johnathan A. , Ordonez Claudia E. , Dudgeon Mathew R. , Sunpath Henry , Pillay Selvan , Moodley Pravi , Kuritzkes Daniel R. , Moosa Mohamed Y. S. , Jones Dean P. , Marconi Vincent C. , Sun Yan V.
Published: July 2022

Genome-wide association studies (GWAS) of circulating metabolites have revealed the role of genetic regulation on the human metabolome. Most previous investigations focused on European ancestry, and few studies have been conducted among populations of African descent living in Africa, where the infectious disease burden is high (e.g., human immunodeficiency virus (HIV)). It is important to understand the genetic associations of the metabolome in diverse at-risk populations including people with HIV (PWH) living in Africa. After a thorough literature review, the reported significant gene–metabolite associations were tested among 490 PWH in South Africa. Linear regression was used to test associations between the candidate metabolites and genetic variants. GWAS of 154 plasma metabolites were performed to identify novel genetic associations. Among the 29 gene–metabolite associations identified in the literature, we replicated 10 in South Africans with HIV. The UGT1A cluster was associated with plasma levels of biliverdin and bilirubin; SLC16A9 and CPS1 were associated with carnitine and creatine, respectively. We also identified 22 genetic associations with metabolites using a genome-wide significance threshold (p-value < 5 × 10−8). In a GWAS of plasma metabolites in South African PWH, we replicated reported genetic associations across ancestries, and identified novel genetic associations using a metabolomics approach.
Quercetin Decreases Corneal Haze In Vivo and Influences Gene Expression of TGF-Beta Mediators In Vitro
Authors: McKay Tina B. , Kivanany Pouriska B. , Nicholas Sarah E. , Nag Okhil K. , Elliott Michael H. , Petroll W. Matthew , Karamichos Dimitrios
Published: July 2022

We have previously reported the flavonoid, quercetin, as a metabolic regulator and inhibitor of myofibroblast differentiation in vitro. Our current study evaluated the effects of topical application of quercetin on corneal scar development using two different animal models followed by RNA analysis in vitro. Wild-type C57BL/6J mice were anesthetized and the corneal epithelium and stroma were manually debrided, followed by quercetin (0.5, 1, 5, or 50 mM) or vehicle application. Corneal scarring was assessed for 3 weeks by slit lamp imaging and clinically scored. In a separate animal study, six New Zealand White rabbits underwent lamellar keratectomy surgery, followed by treatment with 5 mM quercetin or vehicle twice daily for three days. Stromal backscattering was assessed at week 3 by in vivo confocal microscopy. In mice, a single dose of 5 mM quercetin reduced corneal scar formation. In rabbits, stromal backscattering was substantially lower in two out of three animals in the quercetin-treated group. In vitro studies of human corneal fibroblasts showed that quercetin modulated select factors of the transforming growth factor-β (TGF-β) signaling pathway. These results provide evidence that quercetin may inhibit corneal scarring. Further studies in a larger cohort are required to validate the efficacy and safety of quercetin for clinical applications.
Gut Microbiome in Inflammatory Bowel Disease: Role in Pathogenesis, Dietary Modulation, and Colitis-Associated Colon Cancer
Authors: Gubatan John , Boye Theresa Louise , Temby Michelle , Sojwal Raoul S. , Holman Derek R. , Sinha Sidhartha R. , Rogalla Stephan R. , Nielsen Ole Haagen
Published: July 2022

The gut microbiome has increasingly been recognized as a critical and central factor in inflammatory bowel disease (IBD). Here, we review specific microorganisms that have been suggested to play a role in the pathogenesis of IBD and the current state of fecal microbial transplants as a therapeutic strategy in IBD. We discuss specific nutritional and dietary interventions in IBD and their effects on gut microbiota composition. Finally, we examine the role and mechanisms of the gut microbiome in mediating colitis-associated colon cancer.
Zircon U-Pb Dating and Metamorphism of Granitoid Gneisses and Supracrustal Rocks in Eastern Hebei, North China Craton
Authors: Duan Zhanzhan , Wei Chunjing , Li Zhuang , Zhang Cong
Published: July 2022

Granitoid gneisses dominated by tonalitic–trondhjemitic–granodioritic (TTG) compositions, with metamorphic supracrustal rocks consisting of sedimentary and volcanic rocks, are widely exposed in the Eastern Hebei terrane, North China Craton (NCC). This study presents systematic zircon U–Pb geochronological and whole-rock geochemical data of the Neoarchean granitoid gneisses and supracrustal rocks in Eastern Hebei. Zircon U–Pb isotopic dating for the representative samples reveals that magmatic precursors of granitoid gneisses were emplaced between 2524 ± 7 and 2503 ± 12 Ma, and the protoliths of the pelitic granulites were deposited in the Late Neoarchean era. Both of them have been subjected to granulite facies metamorphism during 2508 ± 10 to 2468 ± 33 Ma, coeval with the intrusion of syenogranitic pegmatite (2488 ± 5 Ma). Zircon ages of 2.45–2.01 Ga obtained from the analyzed samples were considered mixed data from 2.53–2.48 Ga and 1.9–1.8 Ga and were chronologically meaningless. Paleoproterozoic metamorphic zircon ages of 1.9–1.8 Ga were usually neglected because of hardly being obtained from TTG gneisses and supracrustal rocks. The tectonic regime during the Neoarchean era was considered to be dominated by vertical tectonism in the Eastern Hebei terrane.
Curcumol Synergizes with Cisplatin in Osteosarcoma by Inhibiting M2-like Polarization of Tumor-Associated Macrophages
Authors: Wang Jincheng , Jin Jialu , Chen Ting , Zhou Qian
Published: July 2022

Osteosarcoma is the most prevalent bone cancer, and chemotherapy is still an indispensable treatment in its clinical practice. Cisplatin (CDDP) has become the most commonly used agent for osteosarcoma, although the outcomes of CDDP chemotherapy remain unsatisfactory because of frequent resistance. Here, we report on a promising combination therapy where curcumol, a bioactive sesquiterpenoid, enhanced CDDP-induced apoptosis to eradicate osteosarcoma cells, and revealed that M2-like macrophages might be the underlying associated mechanisms. First, we observed that curcumol enhanced the CDDP-mediated inhibition of cell proliferation and augmented the apoptosis in osteosarcoma cell lines. Curcumol contributed to preventing the migration of osteosarcoma cells when combined with CDDP. Moreover, this drug combination showed more potent tumor-growth suppression in the orthotopic transplantation of osteosarcoma K7M2 WT cells. We then estimated chemotherapy-associated drug-resistant genes, including ABCB1, ABCC1 and ABCG2, and found that curcumol significantly reversed the mRNA levels of CDDP-induced ABCB1, ABCC1 and ABCG2 genes in the tumor tissue. Moreover, M2-like macrophages were enriched in osteosarcoma tissues, and were largely decreased after curcumol and CDDP treatment. Taken together, these findings suggest that curcumol inhibits the polarization of M2-like macrophages and could be a promising combination strategy to synergize with CDDP in the osteosarcoma.
N-Phenacyldibromobenzimidazoles—Synthesis Optimization and Evaluation of Their Cytotoxic Activity
Authors: Kowalkowska Anna , Chojnacki Konrad , Multan Maciej , Maurin Jan K. , Łukowska-Chojnacka Edyta , Wińska Patrycja
Published: July 2022

Antifungal N-phenacyl derivatives of 4,6- and 5,6-dibromobenzimidazoles are interesting substrates in the synthesis of new antimycotics. Unfortunately, their application is limited by the low synthesis yields and time-consuming separation procedure. In this paper, we present the optimization of the synthesis conditions and purification methods of N-phenacyldibromobenzimidazoles. The reactions were carried out in various base solvent-systems including K2CO3, NaH, KOH, t-BuOK, MeONa, NaHCO3, Et3N, Cs2CO3, DBU, DIPEA, or DABCO as a base, and MeCN, DMF, THF, DMSO, or dioxane as a solvent. The progress of the reaction was monitored using HPLC analysis. The best results were reached when the reactions were carried out in an NaHCO3–MeCN system at reflux for 24 h. Additionally, the cytotoxic activity of the synthesized compounds against MCF-7 (breast adenocarcinoma), A-549 (lung adenocarcinoma), CCRF-CEM (acute lymphoblastic leukemia), and MRC-5 (normal lung fibroblasts) was evaluated. We observed that the studied cell lines differed in sensitivity to the tested compounds with MCF-7 cells being the most sensitive, while A-549 cells were the least sensitive. Moreover, the cytotoxicity of the tested derivatives towards CCRF-CEM cells increased with the number of chlorine or fluorine substituents. Furthermore, some of the active compounds, i.e., 2-(5,6-dibromo-1H-benzimidazol-1-yl)-1-(3,4-dichlorophenyl)ethanone (4f), 2-(4,6-dibromo-1H-benzimidazol-1-yl)-1-(2,4,6-trichlorophenyl)ethanone (5g), and 2-(4,6-dibromo-1H-benzimidazol-1-yl)-1-(2,4,6-trifluorophenyl)ethanone (5j) demonstrated pro-apoptotic properties against leukemic cells with derivative 5g being the most effective.