bluuebunny/crossref_metadata_2025 huggingface dataset:
Novel Biochemical Markers of Glycemia to Predict Pregnancy Outcomes in Women With Type 1 Diabetes
Authors: Meek Claire L. , Tundidor Diana , Feig Denice S. , Yamamoto Jennifer M. , Scott Eleanor M. , Ma Diane D. , Halperin Jose A. , Murphy Helen R. , Corcoy Rosa
Published: January 2021

OBJECTIVE

The optimal method of monitoring glycemia in pregnant women with type 1 diabetes remains controversial. This study aimed to assess the predictive performance of HbA1c, continuous glucose monitoring (CGM) metrics, and alternative biochemical markers of glycemia to predict obstetric and neonatal outcomes.

RESEARCH DESIGN AND METHODS

One hundred fifty-seven women from the Continuous Glucose Monitoring in Women With Type 1 Diabetes in Pregnancy Trial (CONCEPTT) were included in this prespecified secondary analysis. HbA1c, CGM data, and alternative biochemical markers (glycated CD59, 1,5-anhydroglucitol, fructosamine, glycated albumin) were compared at ∼12, 24, and 34 weeks’ gestation using logistic regression and receiver operating characteristic (ROC) curves to predict pregnancy complications (preeclampsia, preterm delivery, large for gestational age, neonatal hypoglycemia, admission to neonatal intensive care unit).

RESULTS

HbA1c, CGM metrics, and alternative laboratory markers were all significantly associated with obstetric and neonatal outcomes at 24 weeks’ gestation. More outcomes were associated with CGM metrics during the first trimester and with laboratory markers (area under the ROC curve generally <0.7) during the third trimester. Time in range (TIR) (63–140 mg/dL [3.5–7.8 mmol/L]) and time above range (TAR) (>140 mg/dL [>7.8 mmol/L]) were the most consistently predictive CGM metrics. HbA1c was also a consistent predictor of suboptimal pregnancy outcomes. Some alternative laboratory markers showed promise, but overall, they had lower predictive ability than HbA1c.

CONCLUSIONS

HbA1c is still an important biomarker for obstetric and neonatal outcomes in type 1 diabetes pregnancy. Alternative biochemical markers of glycemia and other CGM metrics did not substantially increase the prediction of pregnancy outcomes compared with widely available HbA1c and increasingly available CGM metrics (TIR and TAR).
Effects of path accuracy on additively manufactured specimens by laser material deposition using six-axis robots
Authors: Bremer Jan , Walderich Philipp , Pirch Norbert , Schleifenbaum Johannes Henrich , Gasser Andres , Schopphoven Thomas
Published: January 2021

Additive manufacturing technologies such as laser material deposition (LMD) enable manufacturers to economically produce complex and individualized products. However, improved productivity and more economic use of LMD are necessary to benefit from these advantages in a wider range of applications. Through the use of industrial robots in LMD applications, large workspaces and geometric flexibility can be achieved at low cost. Possible effects of reduced path accuracies compared to conventional machines for LMD are not currently quantified. Initial studies suggest effects of path deviations on the component geometry. In this paper, an initial approach to investigate the influence of robot path deviations on the LMD component geometry is introduced. A novel approach toward correlation between path deviations of the robot and resulting surface waviness of the component is presented. The correlation is investigated on two different industrial robots with a powder-based LMD process. Tool center point (TCP) paths of the industrial robots are measured by means of a laser tracker. Robot TCP paths and resulting specimen surface topography are geometrically correlated and compared. The magnitude of the correlation is quantified by the calculation of the Pearson coefficient and a linear approximation of the correlation is made. In addition, the resulting correlation is checked by model calculations regarding the weld path formation as a function of the real tool paths with the aim of quantifying to what extent the waviness of the tool path is reflected in the waviness of the weld track.
Branch and Bound Algorithm and an Improvement for Calculating the Nearest Link of Building a Railway Network
Authors: Elaibi Waleed Mohammed
Published: January 2021

The importance of branch and bound algorithm is the mathematical improvement to find the value of (X) that Maximize or minimize the objective function within a set of feasible solution, as it is reliable on the efficient evaluation of the bounds of regions or branches of the space of the research, whether they are upper or lower. In this paper, we discussed five cases with respect to branching decisions based on network solutions to calculate the nearest link with a short time. From the results, bound and branch algorithm can develop and change the obtaining solutions for the five cases under study.
SOFTWARE FOR PRICE FORMATION AND ESTIMATE RATING IN CONSTRUCTION
Authors: Alekseev Alexander , Gladkih Valeriya
Published: January 2021

The article gives a review of modern pricing and cost estimating processes in construction and considers the existing software products aimed at automating the processes. According to the results of comparative analysis, none of the software products reviewed support the function of editing the prices currently in use. Editing may be rendered possible if a detailed list of construction operations is available. The list may be adjusted on the fly as cutting-edge building technologies are employed and at the same time taking into account operation scenarios in space-limited environment. The importance of updating the existing products or creating a new information management system is emphasized as highly applicable. Functional models of business processes for the head of the business operations office, a specialist of the business operations office and a specialist in cost estimates have been presented in BPMN 2.0 notation. The presented model of pricing and cost estimates is found far from the ideal perspective. The formulas corrected for calculating the estimated cost of construction are given. After a multiuser information management system is developed, it will enable companies adopt the suggested model of pricing and cost estimates. This solution is realistic as the information management system involves segregating the process of corporate pricing carried out by cost estimate specialists and the process of price quoting carried out by specialists from the business operations office. The authors believe that price quoting will thus be done based on corporate prices and with a user-friendly interface.
Perception of Sharia Banks Comparison Between Baby Boomers Generations and Millennial Generations
Authors: Ramlah Ramlah , Bakri Adzan Noor , Munir Nurmaya Fitriani
Published: January 2021

The objectives of this study are 1) To find out the description of the perception of baby boomers about sharia banking; 2) To find out the description of millennial generation perceptions about Islamic banking; 3) To find out how to compare the perception of the two generations of Islamic banks. This writing uses a Descriptive Statistics Method that seeks to illustrate how phenomena that occur when conducting research. Data collection is done through the distribution of questionnaires/questionnaires by directly plunging into the field and given to the elderly and productive age communities. It was testing the research hypothesis using the Maan-Whitney U Test. This research shows that (1) the Baby boomers generation understands well about sharia banking, both in terms of knowledge, religiosity, profit sharing, facilities/services, and location of sharia banking. (2) Millennials better understand Islamic banking, both in terms of knowledge, religiosity, profit sharing, facilities/services, and location of Islamic banking. However, after testing the hypothesis, it was found that there were no differences in the perceptions of the two generations.
The Effect of Company Sizes and Net Working Capital on Cash Holding With Profitability as Intervening Variables in Food and Beverage Sub Sector Companies Registered in Indonesia Stock Exchange
Authors: Awaluddin Murtiadi , Elis Elis , Awaluddin Sri Prilmayanti , Wardhani Rulyanti Susi , Malle Syarif Syharir
Published: January 2021

The COVID-19 pandemic that has hit the world including Indonesia since early 2020 has had The purpose of this study was to determine and analyze the influence of company size and net working capital towards holding cash with profitability as an intervening variable. This Research uses quantitative methods with 2013-2017 observation years. The research sample consisted of 15 food and beverage sub-sector companies listed on the Indonesia Stock Exchange, while the method used was purposive sampling. The analytical method used is multiple linear regression and path analysis. The results showed the size of the company had a negative and not significant effect on profitability, net working capital was positive and not significant on profitability. Company size, net working capital, and profitability have a positive and significant influence on cash holding. Profitability is not able to mediate the effect of company size on cash holding.But profitability is able to mediate the effect of net working capital on cash holding
Hubungan Kekuasaan antara Lembaga Adat dan Pemerintah Desa di Sulawesi Barat
Authors: Zikir Muh , Utaminingsih Nur , Tajuddin Muhammad Saleh
Published: January 2021

Penelitian ini mengkaji tentang hubungan kekuasaan antara lembaga adat dan pemerintah desa dengan maksud untuk mempercepat terwujudnya kesejahteraan masyarakat dan tujuan mengoptimalkan pelayanan, pengelolaan, pembangunan dan pemberdayaan masyarakat. Penelitian ini menggunakan pendekatan kualitatif dan menggunakan teori kekuasaan,teori relasi sosial dan teori peran sosial untuk melihat relasi kekuasaan kedua entitas tersebut. Secara umum, penelitian mengungkapkan bahwa terdapat dua bentuk hubungan kekuasaan lembaga adat dan pemerintah di Desa Tubo yaitu; Pertama, hubungan simbiosis komensalisme yaitu dalam hal pembangunan dan pemberdayaan masyarakat. Kedua,hubungan konflik yaitu menginginkan adanya bantuan pemerintah dalam hal identitas adat (berupa baju adat).
T- Force o Test de Squat Jump. ¿Cuál es la mejor forma de evaluar la potencia máxima en futbolistas profesionales?
Authors: Sánchez-Rojas Isabel Adriana , Herrera-Pinzón MA , Vivas-Mendoza MC , Castro-Rodríguez LE , Argüello-Gutiérrez YP
Published: January 2021

En el deporte de alto rendimiento es importante llevar a cabo un control a los deportistas, el cual debe partir de la evaluación de las capacidades físicas cada cierto periodo de tiempo; para esto se deben escoger las pruebas e instrumentos adecuados considerando el gesto y patrón motriz de cada disciplina, así como las características propias de cada sujeto. El objetivo de la presente investigación se basó en la comparación de dos instrumentos de medición validados en el análisis de la fuerza: T-Force® en el cual se realizó el test de sentadilla y Optogait® con el protocolo de Squat Jump (SJ), para evaluar potencia máxima en futbolistas profesionales de dos equipos de futbol de la ciudad de Bogotá. Estudio descriptivo, de alcance correlacional de tipo transversal. Se contó con la participación de 38 deportistas de género masculino, quienes realizaron las pruebas de SJ en Optogait y test de sentadilla en T-Force; para el procesamiento y análisis de los datos se realizó una prueba T para muestras relacionadas. Se encontraron diferencias significativas entre los resultados de ambas pruebas, donde la potencia máxima obtenida fue más alta con el test de T-Force, pero la desviación de los datos fue menor en el caso del Optogait. De acuerdo con los resultados, se determinó que el mejor método para la medición de la potencia máxima en futbolistas es el T-Force.
Quality Analysis Of Liquid Organic Fertilizer Using Raw Vegetable Waste From Pasar Baru Kabupaten Tuban
Authors: Nurfitria Nia , Febriyantiningrum Kuntum , Rahmawati Annisa
Published: January 2021

This study aims to determine the manufacturing process and the quality of liquid organic fertilizer made from vegetable waste from Pasar Baru, Tuban Regency. Liquid organic fertilizer is done as a solution to the amount of vegetable waste which is the most waste produced by Pasar Baru in Tuban Regency with the amount reaching 2 tons / day. This large amount of vegetable waste will cause environmental problems if not handled and treated properly. The method used in making liquid organic fertilizer is semi anaerobic fermentation using drum composter with the addition of EM-4 bioactivator. The quality of liquid organic fertilizer will be seen based on the physical properties and the results of the analysis of macro nutrient content and adjusted to SNI determined by Permentan No. 70 Th. 2011. The results of the analysis showed that physical properties pH and temperature are fullfill the standard of SNI Permentan No.70 Th. 2011. But for the content of macro elements of C-organic, N, P, and K total are not fullfill the standard.
Stan zanieczyszczenia powietrza w 2017 roku w województwie śląskim oraz jego wpływ na zdrowie człowieka
Authors: Góra Dariusz
Published: January 2021

Za cele pracy przyjęto ocenę poziomu zanieczyszczenia powietrza atmosferycznego pyłem zawieszonym PM2,5 i PM10 oraz benzo(a)pirenem w 2017 roku w województwie śląskim oraz przedstawienie ich negatywnego (toksycznego) wpływu na organizm człowieka. Przeprowadzona analiza wykazała, że najwyższe średnioroczne stężenie benzo(a) pirenu w województwie śląskim występowało głównie na terenie aglomeracji rybnicko-jastrzębskiej (16 ng/m3) oraz w Pszczynie (14 ng/m3), pyłu zawieszonego PM2,5 głównie w Gliwicach i Katowicach (39 μm/m3) i w Bielsku-Białej (32 μm/m3), a pyłu zawieszonego PM10 w Pszczynie (56 μm/m3) i w Katowicach (52 μm/m3). W celu poprawy stanu powietrza atmosferycznego w województwie śląskim i innych obszarów o wysokim stopniu urbanizacji należy przede wszystkim ograniczyć źródła niskiej emisji, czyli emisję szkodliwych pyłów i gazów pochodzących z niskich emitorów.
Joint analysis of rock mass stress state and elasticity modulus during shaft sinking
Authors: Balek A. E. , Ozornin I. L. , Kayumova A. N.
Published: January 2021

The article presents an innovative procedure for the joint stress-strain and elasticity modulus analysis in high-strength rock masses with spacing from a few to tens meters. The procedure includes measurement of elastic convergence of rock walls due to deeper penetration of the foot of a vertical shaft and the analysis of measured displacements of check points along the shaft cross-section perimeter with subsequent two-stage solution of an inverse geomechanical problem. In the first stage, in the lobed diagram of measured displacements of check points, the azimuths of axes of the principal horizontal stresses in surrounding rock mass are determined. In the second stage, the process of deeper penetration of the shaft foot is modeled with different scenarios of the rock mass stress-strain behavior set as varied principal horizontal stresses at the known azimuths of their main axes. Then, the model and in-situ measurement results are compared using the analysis of variance ANOVA. The wanted variant of the stress-strain behavior and the associated modulus of elasticity, such that deviation of the actually measured displacements of check points from the model values is minimal, is identified by the extremum analysis of the experimental diagrams. The procedure was successfully tested in Vspomogatelny and Skipovoi vertical shafts of the Tenth Anniversary of Independence of Kazakhstan mine within Donskoy Mining and Processing Plant, in qualitatively different geological conditions: high-strength rock mass areas categorized as unstable and stable. In unstable rocks, the measured elasticity modulus Е = 3,5 ± 0,7 GPa made 6 %-16 % of the elasticity modulus in samples. In the stable rock mass, the measured modulus Е = 36,6 ± 7,7 GPa almost coincided with the elastic modulus of samples.
Сomprehensive evaluation of strategy for mining of iron ore deposits by environmentally-balanced underground geotechnology
Authors: Sokolov I. V. , Smirnov A. A. , Nikitin I. V. , Solomein Yu. M.
Published: January 2021

For the purpose to solve the problem of reducing the negative impact of mining and processing production on the environment that is relevant for most mining regions of Russia, options of geotechnological strategy for mining of iron ore deposits on the basis of an ecologically balanced integrated underground geotechnology of extraction and processing of iron ore, which allow to utilize the entire volume of mining and processing waste in the mined out space and transfer the most environmentally hazardous enrichment process under the ground, have been formed. Technological schemes for chamber excavation of floors in ascending order have been developed, which make it possible to abandon the formation of ore pillars, thereby increasing the extraction of ore from the bowels, and using the worked out space for waste storage in the form of a dry backfill. Based on economic and mathematical modeling and a comprehensive assessment according to the environmental and economic criterion for the conditions of mining in a new step of one of the largest iron ore deposits in Russia the most effective option of geotechnical strategy has been established. Use of an ascending-descending order of floor mining with an optimal ratio of mining systems with laying out the worked out space and systems with collapse depending on the content of the useful component in the ore mined, the amount of space mined current tab and the volume of tailings used as backfill material, allows to utilize the entire volume of mining and processing waste in the mined out space and effectively to develop of reserves in a new step.
Methodological aspects of transportation system adaptation in open pit mines
Authors: Bakhturin Yu. A.
Published: January 2021

The role of adaptation as an interdisciplinary phenomenon and the necessity of its evolvement in engineering sciences, including mining, is stated. The notion of “open pit transportation system adaptation” is defined. The research was aimed to justify the choice of a methodology for adapting transportation systems in open pit mines, as well as to demonstrate possibility of the transportation system behavior determination and forecasting. In accordance with the definition, the state of a transportation system in the course of adaptation is described. It is shown that the theory of transportation systems for open pits and the theoretical principles are the mainframe. The theory features flexibility, is continuously developed and upgraded, meets the recent methodological standards and can serve the basis of structural and parametric adaptation. The case-studies of the efficient problem solution in mining using the universal simulation model of transportation system functioning in open pit mines developed at the Institute of Mining, Ural Branch RAS are presented. The scope of the applied research embraced: validation of parameters for loading-and-rehandling points in the dump truck- belt-rail transport flowcharts; determination of carrying capacity of rail tracks in open pits; justification of transportation system parameters for open pit mines based on the interactive modeling. The theoretical methodology framework for transportation system adaptation in open pit mines is presented, which is the joint application of the theory of transportation systems in deep open pit mines in structural and structural-and-parametric adaptation and the universal interactive simulation model of transportation system functioning in open pits in parametric adaptation.
The resistance to Aristotelianism in Jewish culture: game-theoretical analysis of the conflict around Maimonides' manuscripts in the 13th century
Authors: Gershowitz Uri , Kuzyutin Denis
Published: January 2021

The Maimonidean Controversy at the beginning of the 13th century was one of the most significant conflicts in the midst of the Jewish diasporas in the Middle Ages. The conflict followed a vivid discussion on the treatises of Maimonides and the interpretation of Judaism in the light of Aristotelian philosophy. Almost all of major Jewish communities in Europe were drawn in this conflict. Moreover, at some point the conflict expanded outside of the Jewish world, so that some works of Maimonides were burnt by the Christian Inquisition as heretical books. Despite the significance of these events and the trace left in the memory of the Jewish people, there is not much reliable evidence about them. The authors aim to discuss the history of this conflict, focusing on the problematic aspects of the Maimonides’ teaching, and to make a reconstruction of the events occurred, to provide a specification of main characteristics of the conflict interaction (the players, their strategies and preferences, possible outcomes of the conflict, conflict dynamics, etc.), to design a game-theoretical model of the social conflict under consideration and to explore this model using the methods of mathematical game theory. It turns out that the majority of the players' actions correspond to optimal behavior concepts employed in game theory (bargaining solutions, Pareto efficiency, Nash equilibria). However, some actions obviously contradict the concept of rational behavior (one of the fundamental assumptions in mathematical game theory), and namely these actions induced the conflict escalation and such a tragic outcome.
Aristotle’s criticism of the “like is known by like” principle (Commentary on De anima II 5, 416b 32 – 417a 20)
Authors: Mesyats Svetlana
Published: January 2021

One of the principles underlying Aristotle’s theory of sense perception is that the sense faculty is potentially such as the sensible object is actually. On closer examination, this statement turns out to be a modernization of the ancient rule "like is known by like", shared by most of the early Greek philosophers, including Empedocles and Plato. The paper shows that though Aristotle criticizes this principle in his treatise On the Soul, he doesn’t really abandon it. On the contrary, he retains it for his own theory of sense perception while using the notions of the possible and the actual. The paper is written in the form of a line-by-line commentary to De anima II 5 416b 32–417a 20, where Aristotle reproaches his predecessors for the inconsistency and contradictions of their theories; shows that the “like is known by like” principle entails certain difficulties, and solves these difficulties by introducing his own theory of being moved and acted upon, according to which the patient is in a sense unlike the agent and in a sense like it.
Iconography of Plato in antiquity and in medieval orthodox painting
Authors: Dorofeev Daniil Yu. , Svetlov Roman V. , Mikeshin Mikhail I. , Vasilyeva Marina A.
Published: January 2021

The article is devoted to the topic of visualization, which is relevant for the modern world in general and scientific knowledge in particular, investigated through the image of Plato in Antiquity and in medieval Orthodox painting. Using the example of Plato’s iconography as a visual message, the authors want to show the great potential for the development of the visual history of philosophy, anthropology and culture in general, as well as the new visually oriented semiotics and semantics of the image. This approach reveals expressively and meaningfully its relevance for the study of Plato’s image, together with other ancient philosophers’ images, in Orthodox medieval churches in Greece, Serbia, Romania, Bulgaria and, of course, ancient Russia in the 15th-17th cc, allowing to see the great ancient Greek philosopher from a new perspective.
When did Eunapius write his school biographies? To the problem of the dating of «Vitae Sophistarum»
Authors: Vedeshkin Mikhail
Published: January 2021

This article examines the problem of the dating of Eunapius’ "Lives of Philosophers and Sophists" - one of the main sources of information on the history of Late Antique education, intellectual tradition and school culture. Arguments are put forward in favor of the fact that Eunapius’ story about the necrolatry of Christian monks who settled in the Egyptian Canopus, reflects the assertion of the cult of relics of St. Cyrus and John, dating back to the time of the Archbishopric of Cyril of Alexandria (412 – 444). These conclusions make it possible to correct the well-established historiographic tradition, according to which "Lives of Philosophers and Sophists" was published around 399–400, and enhance F. Paschoud's hypothesis, that the text of this work was composed no earlier than 412.
Jan Amos Komensky and his (anti)aristotelian “Physics”: an example of an attempt to overcome Aristotle in the 17th century natural philosophy
Authors: Zolotukhina Anastasia
Published: January 2021

At the beginning of the 17th century there have been many attempts to overcome Aristotelian physics. One of the trends was the so-called "Mosaic physics" based on Scripture, not on the texts of Aristotle. The “Physicae Synopsis” by J.A. Komensky shows one of the options for such overcoming, with all its difficulties and successes.
PLAYING AND LAUGHING GODS OF PLATO’S DIALOGUES IN THE COMMENTARIES OF PROCLUS
Authors: Kurdybaylo Dmitry , Kurdybaylo Inga
Published: January 2021

“Socrates’ irony” is a well-known topos even for those readers who are far from ancient philosophy. Dialogues of Plato contain different modes of humour, from mild self-irony to quite sarcastic tones. Plato’s gods are ‘playful,’ they treat people as those were ‘playthings.’ The best way of mortals’ life is to play also, spending their time in “sacrificing, singing, and dancing.” However, Neoplatonic commentaries to Plato tend to avoid explicit laughter and any direct mode of humour. Proclus Lycaeus, one of the most fruitful commentators of Plato, seems to disregard anything ludicrous in Plato’s writing. The places, where Plato speaks about laughter or playing games, are explained by Proclus as signs to some kind of divine activity towards the material realm. Even smile and laughter of particular humans are interpreted in the same way as symbols (synthēmata) of gods’ providence. What Proclus discusses in minor details, is the dialectics of gods’ procession into the sensible world, causing substantiation of the universe, and retention of the internal bonds that keep it eternal and unchangeable. Similarly, temporary particular beings also benefit from divine providence, which fortifies their vital capabilities. In general, these forms of providence are depicted by “the undying laughter” of gods. In spite of this approach seeming to be superfluously ‘scholastic’ and therefore losing the dramatic perspective of Plato’s writings, we suggest that Proclean interpretation may assume laughter to be related to some theurgic practice. Therefore, reading and interpretation the game- and laughter-related passages of Plato could have been considered themself a kind of theurgic “sacred play.”
A living person against the laws of space: Hebrew and Ancient Greek summands of European outlook
Authors: Tantlevskij Igor , Evlampiev Igor
Published: January 2021

The article deals with the basic features of ancient Greek and ancient Jewish world outlook and analyzes their role in European history down to the 20th century. Attention is drawn to the fact that the fundamental difference of the ancient Greek worldview manifests itself in the absolute prevalence of spatial concepts, while time is understood by the model of "eternal return", the repetition of the same, rather than as a history that enriches man. In the center of the ancient Jewish worldview, on the contrary, is the idea of time as a historical process, which includes an endless dialogue between man and God, leading a person to maturity. Interpretations of the key Hebrew worldview concept of hā-ʻōlām as the Universe eternity and the Universe as duration are proposed and analyzed. The article shows that the idea inherited by Christian Europe from the ancient Greeks about the perfect arrangement of the Universe (Cosmos), conforming to the laws of nature, became the deepest reason for the domination of scientific rationality in modern civilization. At the same time the newest worldview tendencies connected with philosophy of life, intuitivism, existentialism, protecting the idea of irrational incomprehensibility of human life, can be recognized as originating from the Hebrew worldview. It was Henri Bergson who has clearly shown the opposite of these two trends within the European worldview. His concept of true time, understood as duration, memory and history, reveals striking coincidences with ancient Jewish conceptions of time and history. According to Bergson, duration is the essence of man and at the same time is the absolute being from which the Universe comes; this leads to radical anthropocentrism, which can be considered as a distant consequence of biblical anthropocentrism.
Nuances in theory and practice of the Eurasian integration concept
Authors: Kusainov Khaslan K.
Published: January 2021

The processes of Eurasian economic integration development have not been effective as expected. One of the factors creating contradictions and certain imbalance of interests between the member states of the Eurasian economic community is the increasing prevalence of political aspects over the economic ones, which was clearly manifested in the EAEU development strategy until 2025. In the author’s opinion, the reason lies in a lack of forecasting and analytical tools efficiency by which decisions are taken in supranational bodies of the association. It seems appropriate to develop a set of tools based on the complex of models taken from optimizing cross-sectoral interregional model (OCIM) developed in the 1960s in the Institute of economics and industrial engineering (Novosibirsk). This model is widely used nowadays, as it allows to increase the level of scientific foundation in the decision-making for the further development of Eurasian integration.
Formation of institutional environment in the ecological sphere (by the example of BAT implementation)
Authors: Burmatova Olga P.
Published: January 2021

The article analyses institutional aspects of the formation of environmental policy in Russia. It shows a number of inefficient institutional conditions which can hardly contribute to the improvement of modern state environmental policy. Special attention is paid to the development and application of environmental legislation largely determining the state of the institutional environment as a whole, which affects the formation and effectiveness of various environmental protection management elements. The paper explains the main reasons why the Russian environmental legislation is weak, and proposes possible directions for its improvement. The proposed recommendations can be used to develop key elements of the environmental management mechanism. By the example of establishing legislative framework for the transition to best available technologies, the article shows possibilities and problems of such a transition in Russia. The advantages and disadvantages of the accepted categorization of the objects according to the degree of their negative impact on the environment with the issuance of integrated environmental permit as one of the main areas of activity in the transition to the best available technologies are analyzed.
Construction and Use of the Regional Input-Output Model with Environmental and Economic Development Blocks
Authors: Baranov Аlexander О. , Pavlov Victor N. , Tagaeva Tatiana O. , Slepenkova Yuliia M.
Published: January 2021

The paper analyzes environmental-economics models developed by foreign and Russian scientists. The first attempts to combine both economic and environmental issues in mathematical modeling were made in the 1960s, with most of them been theoretical due to lack of necessary data. With the development of modeling approaches, following on Wassily Leontief’s models, an environmental block has been included into input-output models. However, most of the existing models can hardly be applied to practice due to lack of statistical data and the absence of inter-industry approach. Even today the main restricting factor for these models to be used in practice is still limited availability of information, including not only economic but also environmental data, which is especially critical for regional researches, as the number of statistical indicators for the regions is much lower than at the macro level.
The article provides mathematical description of the input-output model with an environmental block. The model is developed at the Institute of Economics and Industrial Engineering of the Siberian Branch of the RAS in collaboration with the Novosibirsk State University. The model can be used for regional researches, given the input-output tables for the region is available.
Current issues in the development of multi-agent decision support systems at the sub-federal level
Authors: Suslov Victor I. , Kostin Vitalii S. , Ivanov Evgeny Yu. , Ibragimov Naimjon M. , Novikova Tatyana S. , Tsyplakov Alexandr A.
Published: January 2021

The article reveals the problems which may arise in the development of multi-agent information systems for modeling regional economy (MASMRE) based on geographic information and agent-based approaches to modeling economic space as well as to studying and forecasting the specifics of emerging spatial systems and the ways these systems may occur.
MASMRE proposes an organizational system and open source tools to implement modern digital technologies and also an agent-based approach to modeling the regional economy, which helps to sustain innovative momentum for scientific and scientific-technical interaction, conduct joint research in remote access by providing accessible services, modules and algorithms, and allows the local governments, businesses and non-profit organizations to plan and monitor various projects implemented in a particular territory.
Mutação RAD51D e o câncer de mama: relato de caso e achados de literatura
Authors: Ribeiro Paulo Victor Zattar , Weissheimer Ana Julia Cordeiro , Plucinski Aline , Tondello Grégori Conte
Published: January 2021

Sabe-se que a predisposição genética pode aumentar a suscetibilidade ao desenvolvimento de cânceres. O desenvolvimento do sequenciamento de nova geração (NGS) permitiu a disponibilização mais ampla do painel multigenes relacionados ao câncer de mama. Como por exemplo, o RAD51D que faz parte de um dos 5 parálogos dos genes RAD51 relacionados com o reparo de DNA. Essas são mutações raras e atribuem um maior risco de câncer ovariano e um potencial risco aumentado em câncer de mama triplo negativo. Neste trabalho, relatamos o caso de uma paciente feminina, saudável, 31 anos. Apresentou nódulo palpável em mama direita e achados ultrassonográficos de BI-RADS 4. A biópsia revelou tumor triplo negativo invasivo da mama e estadiamento pT2pN0M0 (IIA). Após negatividade de alterações moleculares nos genes BRCA1 e BRCA2, decidiu pela realização do NGS. Os dados de sequência foram comparados com a versão GRCh37/hg19 do genoma humano. O mesmo revelou alteração patogênica em heterozigose no gene RAD51D. Ainda não há evidência científica suficiente para afirmar que o gene RAD51D possui relação ao câncer de mama. Inferindo uma necessidade de mais estudos na área.
Perceptions of stakeholders regarding the foundation course
Authors: Yograj Sabita , Gupta Rajiv Kumar , Bhat Anjali Nadir , Badyal Dinesh Kumar , Arora Arushi , Arora Arun
Published: January 2021

Objectives:

Medical education is an ever-changing field with the need for hour. Patient-doctor relationships are continuously evolving with increasing awareness of the patients. This study aims to determine the perceptions of stakeholders (students, faculty and administrators) about the new foundation course implemented by MCI in all medical colleges in India from batch 2019 to 2020 onwards.

Materials and Methods:

This study was conducted on 90 Phase-I MBBS students, 38 faculty members and 15 administrators involved in conducting the foundation course. All stakeholders answered an open-ended questionnaire. Data were converted to percentages and analysed.

Results:

Students reported improvement in communication skills and knowledge about ethics concerning to medical practice. They also reported improved interaction with the faculty. Their perceptions were confirmed by other stakeholders. The foundation course was rated by two-third of administrators and half of the faculty between 80% and 90%, while one-third of students between 70% and 80%.

Conclusion:

The impact of the foundation course on Indian Medical Graduate training has a long way to go, the beginning seems to be promising in the form of achievement of short-term outcomes indicated in this study, it appears that soon the intermediate and long-term outcomes will also be achieved, leading to a better health-care system.
Deep Generative Models for Ligand-based de Novo Design Applied to Multi-parametric Optimization
Authors: Perron Quentin , Mirguet Olivier , Tajmouati Hamza , Skiredj Adam , Rojas Anne , Gohier Arnaud , Ducrot Pierre , Bourguignon Marie-Pierre , Sansilvestri-Morel Patricia , Do Huu Nicolas , Gellibert Françoise , Gaston-Mathé Yann
Published: January 2021

Multi-Parameter Optimization (MPO) is a major challenge in New Chemical Entity (NCE) drug discovery projects, and the inability to identify molecules meeting all the criteria of lead optimization (LO) is an important cause of NCE project failure. Several ligand- and structure-based de novo design methods have been published over the past decades, some of which have proved useful multiobjective optimization. However, there is still need for improvement to better address the chemical feasibility of generated compounds as well as increasing the explored chemical space while tackling the MPO challenge. Recently, promising results have been reported for deep learning generative models applied to de novo molecular design, but until now, to our knowledge, no report has been made of the value of this new technology for addressing MPO in an actual drug discovery project. Our objective in this study was to evaluate the potential of a ligand-based de novo design technology using deep learning generative models to accelerate the discovery of an optimized lead compound meeting all in vitro late stage LO criteria.
Planar and Rigid Pyrazine Based TADF Emitter for Deep Blue Bright Organic Light Emitting Diodes
Authors: Rajamalli P , Chen Dongyang , Madayanad Suresh Subeesh , Tsuchiya Youichi , Adachi Chihaya , Zysman-Colman Eli
Published: January 2021

Two blue thermally activated delayed fluorescence (TADF) emitters bearing di-tert-butyl carbazoles as the electron donor groups and pyrazine (DTCz-Pz) or dipyrazine (DTCz-Pz) as the electron acceptor are presented. The DFT calculations predict DTCz-Pz and DTCz-DPz to possess high S1 energies (3.19 eV and 3.08 eV, respectively), and relatively large EST values (0.52 eV and 0.56 eV, respectively). The closely layered intermediate triplet states between S1 and T1, predicted by DFT calculations, are expected to facilitate the reverse intersystem crossing (RISC) and improve spin-vibronic coupling efficiency between the excited states even the relatively larger ΔESTs. The ΔESTs for DTCz-Pz and DTCz-DPz are 0.27 eV and 0.38 eV, and both molecules show high photoluminescence quantum yields (65%, and 70%, respectively) and the decay lifetimes show temperature dependence in a PPT host, which is consistent that both molecules are TADF emitters in PPT. The OLEDs based on DTCz-Pz exhibit deep blue emission with λEL of 460 nm and CIE of (0.15, 0.16). The maximum external quantum efficiency (EQEmax) reaches 11.6%, with a maximum luminance (Lmax) of up to 6892 cd m-2, while the device based on DTCz-DPz exhibits sky blue emission with λEL of 484 nm and CIE of (0.15, 0.30), an EQEmax of 7.2%, and Lmax of 8802 cd m-2.
Strategic Synthesis of ‘Picket Fence’ Porphyrins Based on Nonplanar Macrocycles
Authors: Norvaisa Karolis , Yeow Kathryn , Twamley Brendan , Roucan Marie , Senge Mathias O..
Published: January 2021

Traditional ‘picket fence’ porphyrin systems have been a topic of interest for their capacity to direct steric shielding effects selectively to one side of the macrocycle. Sterically overcrowded porphyrin systems that adopt macrocycle deformations have recently drawn attention for their applications in organocatalysis and sensing. Here we explore the combined benefits of nonplanar porphyrins and the old molecular design to bring new concepts to the playing field. The challenging ortho-positions of meso-phenyl residues dodecasubstituted porphyrin systems led us to transition to less hindered para- and meta-sites and develop selective demethylation based on the steric interplay. Isolation of the symmetrical target compound [2,3,7,8,12,13,17,18-octaethyl-5,10,15,20-tetrakis(3,5-dipivaloyloxyphenyl)porphyrin] was investigated under two synthetic pathways. The obtained insight was used to isolate unsymmetrical [2,3,7,8,12,13,17,18-octaethyl-5,10,15,20-tetrakis(2-nitro-5-pivaloyloxyphenyl)porphyrin]. Upon separation of the atropisomers, a detailed single-crystal X-ray crystallographic analysis highlighted intrinsic intermolecular interactions. The nonplanarity of these systems in combination with ‘picket fence’ motifs provides an important feature in the design of supramolecular ensembles.
IS SPACE AN ABSTRACT CONCEPT OR MATERIAL REALITY?
Authors: Самсонов Владимир Михайлович , Петров Евгений Кузьмич
Published: January 2021

Представлен критический анализ различных вариантов субстанциальной и реляционной концепций пространства. Предложена собственная концепция пространства, названная абстрактно-математической или реляционной в широком смысле. В соответствии с этой концепцией все другие, адекватные, на наш взгляд, концепции, включая эмпирические и геометрические, сознательно или интуитивно «привязаны» к некоторому множеству, между элементами которого заданы определенные отношения, например метрические. Сделан и обоснован вывод о том, что интерпретации пространства как некоторой материальной или нематериальной деформируемой среды являются физически неадекватными.

A critical analysis is presented of various variants of the substantial and relational concepts of space and time. Our own concept of space, called abstract-mathematical or relational in a broad sense, is proposed. In accordance with this concept, all other adequate, in our opinion, ones, including empirical and geometric, are consciously or intuitively «tied» to a certain set, between the elements of which some relations are prescribed, for example metric ones. A conclusion is made and substantiated that any interpretation of space as some material or non-material deformable medium is physically inadequate.
In vitro regeneration and acclimatization of pineapple (Ananas comosus L. Merr.
var. MD2)
Authors: Ab Rahman N.A. , Abdul Latif N. , Udin E.Z. , Awal A. , Shamsiah A.
Published: January 2021

Ananas comosus L. Merr. is asexually propagated through the conventional method from
its crowns, slips, hapas, and suckers. Plant tissue culture technique is applied for mass
production of clonal pineapple within a shorter period compared to conventional
propagation. Hence, this research aims to study the effect of coconut water and optimum
sucrose concentration for in vitro growth performance of pineapple. In addition, this
research also aims at optimizing the fertilization mechanism for the acclimatization of
clonal pineapple ex vitro. The in vitro regeneration was performed by adding a different
volume of coconut water and concentration of sucrose into the prepared culture media
supplemented with 2.00 mg/L 6-Benzylaminopurine (BAP) and 1.00 mg/L
Naphthaleneacetic acid (NAA). For acclimatization method, two different types of
fertilizer served as treatments which were compound fertilizers (NPK 15:15:15) and
controlled-release fertilizer (AJIB CRF, NPKMg 10:5:18:3). The planting media consisted
of topsoil, sand, and compost composition in a ratio of 2:1:2. Results showed that culture
media contained 20.00 mL/L coconut water obtained the highest number of shoots
(45.33±7.56). On the other hand, culture media supplemented with 30.00 g/L sucrose
concentration showed the highest number of shoots (47.25±10.81). Meanwhile, the
acclimatization method found that controlled-release fertilizer (AJIB CRF), NPKMg
(10:5:18:3) showed about 90% of survival rate. The mean value for the number of leaves
and leaves length (cm) in acclimatized clonal pineapple using Controlled-release fertilizer
(AJIB CRF) were 5.48±0.96 and 6.00±1.04, respectively. Therefore, the addition of
coconut water, optimum sucrose concentration, and the suitable type of fertilizer in both in
vitro and ex vitro promote a better growth performance of clonal pineapple.
Effect of steaming and frozen storage on polyphenol content and antioxidant properties of Mangifera odorata (Kuini) pulp
Authors: I. Norra , S. Saiful Bahri , H. Hadijah , A.S. Norhartini
Published: January 2021

Mangifera odorata (kuini) is a potential source of antioxidant. As a seasonal fruit and
easily perishable after harvesting, production of kuini pulp was a common practice to
overcome this problem. Steaming treatment were involved in the production of kuini pulp
before being stored at -18°C. These thermal treatment and storage are challenging due to
the fact that it can induce changes of antioxidants properties of kuini pulp. Thus, this study
evaluated the effect of steaming processing and frozen storage on the total phenolic
content (TPC) and antioxidant activity (AOA) measured by ferric reducing antioxidant
power (FRAP) and DPPH radical scavenging activity (RSA) method of M. odorata (kuini)
pulps. Overall, a significant difference was observed for TPC and AOA for steaming kuini
pulp compared to control samples. Steaming processing significantly increased the TPC
and AOA of the kuini pulps (p < 0.05). Significant relationships (p < 0.05) were identified
between total phenolics and total antioxidant activities. Storage at -18°C significantly
affected the TPC and AOA of the frozen kuini pulp samples. After 12 months storage of
all frozen kuini pulp samples, phenolics content was decreased up to 34%; the reducing
power value decreased up to 50%, and DPPH RSA decreased up to 35% of the initial
value. Steam blanching is recommended to enhance the phenolic content and the
antioxidant but, frozen storage at -18°C cannot preserve the phenolic content and the
antioxidant of kuini pulp.
Effect of steam-cooking on (poly)phenolic compounds in purple yam and purple sweet potato tubers
Authors: Cakrawati D. , Srivichai S. , Hongsprabhas P.
Published: January 2021

This study investigated the influences of steam-cooking on (poly)phenolic compounds and
colors in purple yam (Dioscorea alata L.) and purple sweet potato (Ipomoea batatas)
tubers cooked at the household level. Steam-cooking did not significantly change the
contents of total phenolic compounds, flavonoids, anthocyanins and antioxidant capacity
measured by ABTS radical scavenging assay in purple yam (P≥0.05), but lowered the
antioxidant capacity measured by Crocin assay (P<0.05). The liquid chromatograph–
mass spectrometer–Ion Trap–Time of Flight (LCMS-IT-TOF) indicated the
degradation of high MW alatanin B to lower MW alatanins due to the loss of glucose
units. Purple sweet potato, however, responded to steam-cooking differently from purple
yam (P<0.05). Steam-cooking drastically increased total phenolic compounds, flavonoids,
anthocyanins, antioxidant capacities, and retained the vivid reddish-purple color of cooked
purple sweet potato (P<0.05). The stability of polyphenolic compounds in starchy tubers
against steam-cooking at the household level was, in part, due to the different contents of
indigenous phenolic compounds in the raw tubers.