bluuebunny/crossref_metadata_2025 huggingface dataset:
Statistical Damage Constitutive Model for High-Strength Concrete Based on Dissipation Energy Density
Authors: Zhang Liangliang , Cheng Hua , Wang Xiaojian , Liu Jimin , Guo Longhui
Published: July 2021

To study the energy evolution law and damage constitutive behavior of high-strength concrete based on the conventional triaxial compression tests of C60 and C70 high-strength concrete subjected to five different confining pressures, the failure characteristics of high-strength concrete are analyzed at different confining pressures, and the evolution of the input energy density, elastic strain energy density, and dissipation energy density with axial strain and confining pressure are quantified. Combined with a continuous damage theory and non-equilibrium statistical method, the ratio of dissipation energy density of concrete to dissipation energy density corresponding to peak stress is used as the mechanical parameter. Assuming that the mechanical parameter obeys the Weibull distribution laws, the statistical damage variable describing the damage characteristics of concrete were derived. According to the Lemaitre strain equivalent principle, the damage variable is introduced to the generalized Hooke law to establish the statistical damage constitutive model for high-strength concrete. The results show that: (1) the input energy density and dissipation energy density increases with the increase of axial strain, while the elastic strain energy density increases first and then decreases as a function of the axial strain and reaches the maximum value at the peak stress; (2) the input, elastic strain, and dissipated energy densities corresponding to the peak stress of the two high-strength concretes all increase as a function of confining pressure, and the elastic strain energy density corresponding to the peak stress increases linearly as a function of the confining pressure; (3) the statistical damage constitutive model results of C60 and C70 high-strength concrete are in good agreement with the test results, and the average relative standard deviations are only 3.64% and 3.99%. These outcomes verify the rationality and accuracy of the model.
WNT8B as an Independent Prognostic Marker for Nasopharyngeal Carcinoma
Authors: Ngernsombat Chawalit , Prattapong Pongphol , Larbcharoensub Noppadol , Khotthong Krittika , Janvilisri Tavan
Published: July 2021

Background: Members of the Wnt signaling pathway have been shown to play a role in nasopharyngeal carcinoma (NPC) progression. Aim: The purpose of this study was to investigate WNT8B protein expression in NPC patients using tissue microarray (TMA) analysis and to evaluate its correlation with patient survival and clinical parameters. Methods: A total of 82 NPC cases, together with six normal nasopharyngeal tissue samples, were targeted to construct the TMA blocks. The WNT8B protein expression was evaluated by immunohistochemistry and its correlation to the clinicopathological features was investigated. Results: Sixty-two of 82 (75.6%) cases exhibited high WNT8B protein expression while 20/82 (24.4%) cases appeared to have low WNT8B expression. The univariate analysis revealed that systemic metastasis was associated with patient 5-year survival. The multivariate Cox proportional hazard regression analysis showed that WNT8B expression and systemic metastasis were significantly associated with the survival of NPC patients. Furthermore, there was no correlation found between the WNT8B protein expression and other clinicopathological parameters. Conclusion: Our results suggest that the expression of WNT8B is associated with NPC patients’ survival and could serve as an independent prognostic factor for NPC patients.
Ecosystem Services Assessment, Trade-Off, and Bundles in the Yellow River Basin, China
Authors: Yang Jie , Xie Baopeng , Tao Wenqian , Zhang Degang
Published: July 2021

Understanding ecosystem services(ESs)and their interactions will help to formulate effective and sustainable land use management plans, and clarifying the balance and synergy between watershed ecosystem services can provide a basis for the regulation of the ecological environment in different regions of the watershed and the maximization of overall ecological benefits. This paper takes the Yellow River Basin as the research object and uses the Ecosystem Services and Trade Offs (InVEST)model to evaluate the water yield (WY), soil conservation (SC), carbon storage (CS) and habitat quality (HQ) of the Yellow River Basin. The paper adopts the Carnegie-Ames-Stanford Approach (CASA)model to evaluate the net primary productivity (NPP), draws the spatial distribution map of the five ecosystems, analyzes the trade-off and synergy between the five ecosystems using correlation and binary spatial correlation, and expresses it in space. In addition, it adopts self-organizing mapping (SOM) method to identify ecosystem service clusters. The results show that: (1) ES is generally higher in the upper reaches of the Yellow River, and lower in the middle reaches. (2) WY and NPP, HQ, CS and WY are trade-off relationships, and other ecosystem services are synergistic relationships. Trade-offs and synergy show obvious spatial heterogeneity. (3) The ecosystem services of the Yellow River Basin, driven by different factors, can be divided into three areas, namely WY and SC service leading functional areas, HQ and CS service leading functional areas, and NPP service leading functional areas. Finally, it discusses the driving factors of the spatial heterogeneity of the balance of the ecosystem service functions of the Yellow River Basin and the suggestions of land use management in the basin.
Impact of Autonomous Vehicles on the Physical Infrastructure: Changes and Challenges
Authors: Othman Kareem
Published: July 2021

Over the last few years, autonomous vehicles (AVs) have witnessed tremendous worldwide interest. Although AVs have been extensively studied in the literature regarding their benefits, implications, and public acceptance, research on the physical infrastructure requirements for autonomous vehicles is still in the infancy stage. For the road infrastructure, AVs can be very promising; however, AVs might introduce new risks and challenges. This paper investigates the impact of AVs on the physical infrastructure with the objective of revealing the infrastructure changes and challenges in the era of AVs. In AVs, the human factor, which is the major factor that influences the geometric design, will not be a concern anymore so the geometric design requirements can be relaxed. On the other hand, the decrease in the wheel wander, because of the lane-keeping system, and the increase in the lane capacity, because of the elimination of the human factor, will bring an accelerated rutting potential and will quickly deteriorate the pavement condition. Additionally, the existing structural design methods for bridges are not safe to support autonomous truck platoons. For parking lots, AVs have the potential to significantly increase the capacity of parking lots using the blocking strategy. However, the implementation of this parking strategy faces multiple issues such as the inconsistent marking system. Finally, AVs will need new infrastructure facilities such as safe harbor areas.
Compound Odontoma Removed by Endoscopic Intraoral Approach: Case Report
Authors: Hamada Masakazu , Okawa Rena , Nishiyama Kyoko , Nomura Ryota , Uzawa Narikazu , Nakano Kazuhiko
Published: July 2021

A 12-year-old Japanese boy was referred to our hospital for evaluation of a radiopaque area on the left side of the mandible. Radiographic and computed tomographic examinations revealed a radiopaque lesion located on the lingual side, along with permanent tooth eruption. Several small tooth-like structures were noted within the lesion and the mandibular left second premolar was inclined in a mesial direction. An odontoma was clinically diagnosed and surgical removal by an endoscopic intraoral approach under general anesthesia was planned. Reports of oral surgery using an endoscopic approach have been presented, though none for an odontoma. With the expectation that removal of the odontoma would improve dentition in this case, we planned future management. A minimally invasive surgical removal procedure by an endoscopic intraoral approach from the lingual side was performed and good early recovery was noted. The resected tumor consisted of several small tooth-like structures. Histopathological diagnosis was a compound odontoma. One-year follow-up findings showed that the post-surgical course was good.
About the Definition of the Local Equilibrium Lattice Temperature in Suspended Monolayer Graphene
Authors: Coco Marco , Mascali Giovanni , Romano Vittorio
Published: July 2021

The definition of temperature in non-equilibrium situations is among the most controversial questions in thermodynamics and statistical physics. In this paper, by considering two numerical experiments simulating charge and phonon transport in graphene, two different definitions of local lattice temperature are investigated: one based on the properties of the phonon–phonon collision operator, and the other based on energy Lagrange multipliers. The results indicate that the first one can be interpreted as a measure of how fast the system is trying to approach the local equilibrium, while the second one as the local equilibrium lattice temperature. We also provide the explicit expression of the macroscopic entropy density for the system of phonons, by which we theoretically explain the approach of the system toward equilibrium and characterize the nature of the equilibria, in the spatially homogeneous case.
Malware Variant Identification Using Incremental Clustering
Authors: Black Paul , Gondal Iqbal , Bagirov Adil , Moniruzzaman Md
Published: July 2021

Dynamic analysis and pattern matching techniques are widely used in industry, and they provide a straightforward method for the identification of malware samples. Yara is a pattern matching technique that can use sandbox memory dumps for the identification of malware families. However, pattern matching techniques fail silently due to minor code variations, leading to unidentified malware samples. This paper presents a two-layered Malware Variant Identification using Incremental Clustering (MVIIC) process and proposes clustering of unidentified malware samples to enable the identification of malware variants and new malware families. The novel incremental clustering algorithm is used in the identification of new malware variants from the unidentified malware samples. This research shows that clustering can provide a higher level of performance than Yara rules, and that clustering is resistant to small changes introduced by malware variants. This paper proposes a hybrid approach, using Yara scanning to eliminate known malware, followed by clustering, acting in concert, to allow the identification of new malware variants. F1 score and V-Measure clustering metrics are used to evaluate our results.
Ensemble Surrogate Models for Fast LIB Performance Predictions
Authors: Quartulli Marco , Gil Amaia , Florez-Tapia Ane Miren , Cereijo Pablo , Ayerbe Elixabete , Olaizola Igor G.
Published: July 2021

Battery Cell design and control have been widely explored through modeling and simulation. On the one hand, Doyle’s pseudo-two-dimensional (P2D) model and Single Particle Models are among the most popular electrochemical models capable of predicting battery performance and therefore guiding cell characterization. On the other hand, empirical models obtained, for example, by Machine Learning (ML) methods represent a simpler and computationally more efficient complement to electrochemical models and have been widely used for Battery Management System (BMS) control purposes. This article proposes ML-based ensemble models to be used for the estimation of the performance of an LIB cell across a wide range of input material characteristics and parameters and evaluates 1. Deep Learning ensembles for simulation convergence classification and 2. structured regressors for battery energy and power predictions. The results represent an improvement on state-of-the-art LIB surrogate models and indicate that deep ensembles represent a promising direction for battery modeling and design.
Secondary Energy Sources and Their Optimization in the Context of the Tax Gap on Petrol and Diesel
Authors: Korauš Antonín , Gombár Miroslav , Vagaská Alena , Šišulák Stanislav , Černák Filip
Published: July 2021

This paper presents an energy management strategy for secondary energy sources and their optimization in the context of the tax gap on mineral oils represented by the tax gap on petrol and diesel. Energy companies face drastic economic and environmental challenges; therefore, this area necessarily requires the setting up of transparent economic instruments and, of course, production. The tax gap in VAT collection represents the gap between how much the state could potentially collect from VAT in accordance with the law and how much VAT really comes into the state coffers. The loss of tax revenues is caused by unpaid and undeclared tax liability. The Estimation of the Gap on Corporate Tax in Slovakia is a pilot project of the International Monetary Fund (IMF) in cooperation with the Institute for Financial Policy (IFP). The results present the estimation of the tax gap within a two-year delay. It is necessary to consider the estimation of the tax gap in the last two years as preliminary due to possible revisions of the national accounts data. Estimations of the tax gap from 2010 to 2017 indicate a decreasing trend. The significant part of the tax gap decrease can be observed from 2014. The main factor, which determines this decrease, is the improving condition of the Slovak economy. From the point of view of the tax gap, the volume of losses is decreasing and the volume of profit, from which the tax is paid, is increasing.
Efficiency Enhancement of Non-Isolated DC-DC Interleaved Buck Converter for Renewable Energy Sources
Authors: Bereš Matej , Kováč Dobroslav , Vince Tibor , Kováčová Irena , Molnár Ján , Tomčíková Iveta , Dziak Jozef , Jacko Patrik , Fecko Branislav , Gans Šimon
Published: July 2021

The article describes the principles based on which it is possible to obtain energy from renewable sources more efficiently. The principles use the conventional DC-DC interleaved buck converter based on the common electronic component types and the control strategy. A novelty of such a proposed solution lies in the methods which are not new, but with the right combination, better results can be achieved. The resulting method can be implemented into various topologies where the highest efficiency for wide input power is required. In case of the renewable energy sources where the power can vary hugely during the day, the proposed method can be implemented. Therefore, the article provides several steps, from calculation through simulation to experimental results that brings reader close to understanding of a such proposed solution.
Pine Logs Sorting as a Function of Bark Thickness
Authors: Mirski Radosław , Trociński Adrian , Kawalerczyk Jakub , Wieruszewski Marek
Published: July 2021

The process of sorting softwood raw materials is aimed at full automation. Techniques such as laser and optical scanning, used in measuring and sorting wood raw material with the layer of bark, are based on an analysis of the external shape of the log. The consequence of this is the use of constant ranges of bark deductions, which are often affected by errors resulting from averaging the values. The thickness of the bark is influenced by many factors, such as the tree species and the quality of habitat in which the trees have grown. In the case of pine wood, the range of adopted diametral intervals for the processed raw material plays a significant role. The analysis of the automatic sorting results showed numerous cases of a log-size mismatch. In methods that assume the measurement of wood with the bark, deductions for bark should be made based on experiments that take into account the raw resources base. Despite the high correlation between the size of the deduction and the average thickness of the bark (r = 0.85), the mean value of an error of the adjustment to the maximum thickness of the bark in the automatic sorting was 45%. The maximum bark thickness for the analyzed sorting intervals was correlated. The level of the correlation coefficient value was r = 0.72. In order to increase the accuracy of the sorting process, the value of the deduction for bark should be adjusted to the maximum values in each sorting group.
Differences in Ovarian and Other Cancers Risks by Population and BRCA Mutation Location
Authors: Sekine Masayuki , Nishino Koji , Enomoto Takayuki
Published: July 2021

Hereditary breast and ovarian cancer is caused by a germline mutation in BRCA1 or BRCA2 genes. The frequency of germline BRCA1/2 gene mutation carriers and the ratio of germline BRCA1 to BRCA2 mutations in BRCA-related cancer patients vary depending on the population. Genotype and phenotype correlations have been reported in BRCA mutant families, however, the correlations are rarely used for individual risk assessment and management. BRCA genetic testing has become a companion diagnostic for PARP inhibitors, and the number of families with germline BRCA mutation identified is growing rapidly. Therefore, it is expected that analysis of the risk of developing cancer will be possible in a large number of BRCA mutant carriers, and there is a possibility that personal and precision medicine for the carriers with specific common founder mutations will be realized. In this review, we investigated the association of ovarian cancer risk and BRCA mutation location, and differences of other BRCA-related cancer risks by BRCA1/2 mutation, and furthermore, we discussed the difference in the prevalence of germline BRCA mutation in ovarian cancer patients. As a result, although there are various discussions, there appear to be differences in ovarian cancer risk by population and BRCA mutation location. If it becomes possible to estimate the risk of developing BRCA-related cancer for each BRCA mutation type, the age at risk-reducing salpingo-oophorectomy can be determined individually. The decision would bring great benefits to young women with germline BRCA mutations.
High-Throughput SSR Marker Development and the Analysis of Genetic Diversity in Capsicum frutescens
Authors: Zhong Yangmin , Cheng Yuan , Ruan Meiying , Ye Qingjing , Wang Rongqing , Yao Zhuping , Zhou Guozhi , Liu Jia , Yu Jiahong , Wan Hongjian
Published: July 2021

Capsicum frutescens, one of the domesticated species of pepper grown worldwide, is thought to be highly advantageous due to its strong resistance against plant pathogenesis, high productivity, and intense aroma. However, a shortage of molecular markers limits the efficiency and accuracy of genetic breeding for pepper. With the newly developed next-generation sequencing technology, genome sequences of C. frutescens can be generated, which are now available for identifying SSR markers via data mining. In this study, a total of 278,425 SSRs were detected from the pepper genome using MISA software. It was observed that trinucleotides were the dominant repeat motif. This was followed by dinucleotides, tetranucleotides, pentanucleotides, and the hexanucleotides repeat types. (AT)n (TTG)n (AAAT)n (AAATA)n (TATAGA)n is known to be the most common repeat motifs corresponding to dinucleotide to hexanucleotide repeats, respectively. In addition, a total of 240 SSR primers evenly distributed over all 12 chromosomes were designed and screened against 8 C. frutescens cultivars. Of these, 33 SSR markers that have high polymorphism, have been scrutinized for 147 accessions from 25 countries. The dendrogram constructed clustered these accessions into seven major groups. The groups were found to be consistent with their origins. The results obtained in this study provided resources of SSR molecular markers and insight into genetic diversity of the C. frutescens.
On What Could Chinese Mining Enterprises Achieve High-Level Environmental Performance?—Based on the fsQCA Method
Authors: Gao Zhengjie , He Dayi , Niu Shuaifang
Published: July 2021

Enterprise environmental performance has causal complexity. The purpose of this paper is to discover the possible combination of conditions for enterprises to achieve high environmental performance. Based on the resource dependence theory, stakeholder theory, and externality theory, this paper constructs the theoretical framework of enterprise environmental performance evaluation and applies the fsQCA method to study the major influencing factors and mechanism of the environmental performance of listed enterprises in the Chinese mining industry. Based on the data from 2016 to 2019, the results show that there are four configurations of multiple factors leading to high environmental performance. Based on these configurations, three possible paths, internally driven, internally–externally driven, and externally driven, are established to improve environmental performance. Further, we also find that, between profitability and government regulation and between enterprise size and board independence are interchangeable condition variables; public attention outweighs other factors for Chinese mining enterprises. Countermeasures and suggestions from perspectives of government supervision, public concern, and enterprise internal governance are proposed at the end the study.
The Role of Myofunctional Therapy in Treating Sleep-Disordered Breathing: A State-of-the-Art Review
Authors: Carrasco-Llatas Marina , O’Connor-Reina Carlos , Calvo-Henríquez Christian
Published: July 2021

Myofunctional therapy (MFT) may have a role in improving muscle tone and alleviating upper airway collapse in sleep-disordered breathing. The purposes of this state-of-the-art review are to first review systematically the current literature on the effectiveness of MFT in treating sleep-disordered breathing and then to provide an overview of the current understanding of patient selection, side effects, type and duration of exercises, guidance of exercise performance, evaluation of results, and how best to promote adherence. PubMed (Medline), the Cochrane Library, and the EMBASE, Scopus and SciELO databases were checked for relevant studies by three authors, and a total of 23 studies were included. This review focuses only on adults with sleep-disordered breathing. The available evidence shows a positive effect of MFT in reducing sleep apnoea, as measured using polysomnography and clinical variables (including snoring). There is no evidence of the utility of MFT for treating upper airway resistance syndrome, the duration of the effects of MFT, or regarding which MFT protocol is best. Despite these knowledge gaps, the available evidence suggests that MFT is a safe treatment modality.
Exploring the Social Networks’ Use in the Health-Care Industry: A Multi-Level Analysis
Authors: Pianese Tommasina , Belfiore Patrizia
Published: July 2021

The application of social networks in the health domain has become increasingly prevalent. They are web-based technologies which bring together a group of people and health-care providers having in common health-related interests, who share text, image, video and audio contents and interact with each other. This explains the increasing amount of attention paid to this topic by researchers who have investigated a variety of issues dealing with the specific applications in the health-care industry. The aim of this study is to systematize this fragmented body of literature, and provide a comprehensive and multi-level overview of the studies that has been carried out to date on social network uses in healthcare, taking into account the great level of diversity that characterizes this industry. To this end, we conduct a scoping review enabling to identify the major research streams, whose aggregate knowledge are discussed according to three levels of analysis that reflect the viewpoints of the major actors using social networks for health-care purposes, i.e., governments, health-care providers (including health-care organizations and professionals) and social networks’ users (including ill patients and general public). We conclude by proposing directions for future research.
Midstream Players Determine Population-Level Behavior Change: Social Marketing Research to Increase Demand for Lead-Free Components in Pitcher Pumps in Madagascar
Authors: Khaliq Mahmooda , Sommariva Silvia , Buerck Adaline M. , Rakotondrazaka Rinah , Rakotoarisoa Lova , Barrett Luke John Paul , Mihelcic James R.
Published: July 2021

Lead (Pb) exposure through water contamination is an important issue at the intersection of public health and water, sanitation, and hygiene (WASH). Behavior-change programs designed to address this pressing problem rarely take a behavioral-science-informed approach, nor do they consider the role of intermediate players who often influence and support behavior change. Social marketing segments the population and focuses on the consumer/user throughout program development and implementation. To illustrate the social marketing process, this cross-sectional, qualitative design study investigates the use of Pb in the construction and maintenance of household pitcher pumps for potable water in Madagascar. A sample of 18 technicians were interviewed on their current practices, motivators, barriers, and communication channels for knowledge exchange. The results reveal the importance of peers, those considered experts or “market mavens”, and the need for information on the dangers of Pb as an outdated practice for any future intervention. This study advances the notion of a design shift within engineering WASH projects, whereby social/behavioral approaches are used to consider the needs, concerns, and current behaviors of the consumer. We also advocate for engaging intermediate players who often influence behavior change in the rollout of an engineering innovation.
A Case Series Study of Help-Seeking among Younger and Older Men in Suicidal Crisis
Authors: Saini Pooja , Chopra Jennifer , Hanlon Claire A. , Boland Jane E.
Published: July 2021

Due to the continuing high suicide rates among young men, there is a need to understand help-seeking behaviour and engagement with tailored suicide prevention interventions. The aim of this study was to compare help-seeking among younger and older men who attended a therapeutic centre for men in a suicidal crisis. In this case series study, data were collected from 546 men who were referred into a community-based therapeutic service in North West England. Of the 546 men, 337 (52%) received therapy; 161 (48%) were aged between 18 and 30 years (mean age 24 years, SD = 3.4). Analyses included baseline differences, symptom trajectories for the CORE-34 Clinical Outcome Measure (CORE-OM), and engagement with the therapy. For the CORE-OM, there was a clinically significant reduction in mean scores between assessment and discharge (p < 0.001) for both younger and older men. At initial assessment, younger men were less affected by entrapment (46% vs. 62%; p = 0.02), defeat (33% vs. 52%; p = 0.01), not engaging in new goals (38% vs. 47%; p = 0.02), and positive attitudes towards suicide (14% vs. 18%; p = 0.001) than older men. At discharge assessment, older men were significantly more likely to have an absence of positive future thinking (15% vs. 8%; p = 0.03), have less social support (45% vs. 33%; p = 0.02), and feelings of entrapment (17% vs. 14%; p = 0.02) than younger men. Future research needs to assess the long-term effects of help-seeking using a brief psychological intervention for young men in order to understand whether the effects of the therapy are sustainable over a period of time following discharge from the service.
CPRQ: Cost Prediction for Range Queries in Moving Object Databases
Authors: Guo Shengnan , Xu Jianqiu
Published: July 2021

Predicting query cost plays an important role in moving object databases. Accurate predictions help database administrators effectively schedule workloads and achieve optimal resource allocation strategies. There are some works focusing on query cost prediction, but most of them employ analytical methods to obtain an index-based cost prediction model. The accuracy can be seriously challenged as the workload of the database management system becomes more and more complex. Differing from the previous work, this paper proposes a method called CPRQ (Cost Prediction of Range Query) which is based on machine-learning techniques. The proposed method contains four learning models: the polynomial regression model, the decision tree regression model, the random forest regression model, and the KNN (k-Nearest Neighbor) regression model. Using R-squared and MSE (Mean Squared Error) as measurements, we perform an extensive experimental evaluation. The results demonstrate that CPRQ achieves high accuracy and the random forest regression model obtains the best predictive performance (R-squared is 0.9695 and MSE is 0.154).
Rapid Internalization and Nuclear Translocation of CCL5 and CXCL4 in Endothelial Cells
Authors: Dickhout Annemiek , Kaczor Dawid M. , Heinzmann Alexandra C. A. , Brouns Sanne L. N. , Heemskerk Johan W. M. , van Zandvoort Marc A. M. J. , Koenen Rory R.
Published: July 2021

The chemokines CCL5 and CXCL4 are deposited by platelets onto endothelial cells, inducing monocyte arrest. Here, the fate of CCL5 and CXCL4 after endothelial deposition was investigated. Human umbilical vein endothelial cells (HUVECs) and EA.hy926 cells were incubated with CCL5 or CXCL4 for up to 120 min, and chemokine uptake was analyzed by microscopy and by ELISA. Intracellular calcium signaling was visualized upon chemokine treatment, and monocyte arrest was evaluated under laminar flow. Whereas CXCL4 remained partly on the cell surface, all of the CCL5 was internalized into endothelial cells. Endocytosis of CCL5 and CXCL4 was shown as a rapid and active process that primarily depended on dynamin, clathrin, and G protein-coupled receptors (GPCRs), but not on surface proteoglycans. Intracellular calcium signals were increased after chemokine treatment. Confocal microscopy and ELISA measurements in cell organelle fractions indicated that both chemokines accumulated in the nucleus. Internalization did not affect leukocyte arrest, as pretreatment of chemokines and subsequent washing did not alter monocyte adhesion to endothelial cells. Endothelial cells rapidly and actively internalize CCL5 and CXCL4 by clathrin and dynamin-dependent endocytosis, where the chemokines appear to be directed to the nucleus. These findings expand our knowledge of how chemokines attract leukocytes to sites of inflammation.
Stress-Inducible Gene Atf3 Dictates a Dichotomous Macrophage Activity in Chemotherapy-Enhanced Lung Colonization
Authors: Middleton Justin D. , Fehlman Jared , Sivakumar Subhakeertana , Stover Daniel G. , Hai Tsonwin
Published: July 2021

Previously, we showed that chemotherapy paradoxically exacerbated cancer cell colonization at the secondary site in a manner dependent on Atf3, a stress-inducible gene, in the non-cancer host cells. Here, we present evidence that this phenotype is established at an early stage of colonization within days of cancer cell arrival. Using mouse breast cancer models, we showed that, in the wild-type (WT) lung, cyclophosphamide (CTX) increased the ability of the lung to retain cancer cells in the vascular bed. Although CTX did not change the WT lung to affect cancer cell extravasation or proliferation, it changed the lung macrophage to be pro-cancer, protecting cancer cells from death. This, combined with the initial increase in cell retention, resulted in higher lung colonization in CTX-treated than control-treated mice. In the Atf3 knockout (KO) lung, CTX also increased the ability of lung to retain cancer cells. However, the CTX-treated KO macrophage was highly cytotoxic to cancer cells, resulting in no increase in lung colonization—despite the initial increase in cell retention. In summary, the status of Atf3 dictates the dichotomous activity of macrophage: pro-cancer for CTX-treated WT macrophage but anti-cancer for the KO counterpart. This dichotomy provides a mechanistic explanation for CTX to exacerbate lung colonization in the WT but not Atf3 KO lung.
Research on Generation Method of Grasp Strategy Based on DeepLab V3+ for Three-Finger Gripper
Authors: Jiang Sanlong , Li Shaobo , Bai Qiang , Yang Jing , Miao Yanming , Chen Leiyu
Published: July 2021

A reasonable grasping strategy is a prerequisite for the successful grasping of a target, and it is also a basic condition for the wide application of robots. Presently, mainstream grippers on the market are divided into two-finger grippers and three-finger grippers. According to human grasping experience, the stability of three-finger grippers is much better than that of two-finger grippers. Therefore, this paper’s focus is on the three-finger grasping strategy generation method based on the DeepLab V3+ algorithm. DeepLab V3+ uses the atrous convolution kernel and the atrous spatial pyramid pooling (ASPP) architecture based on atrous convolution. The atrous convolution kernel can adjust the field-of-view of the filter layer by changing the convolution rate. In addition, ASPP can effectively capture multi-scale information, based on the parallel connection of multiple convolution rates of atrous convolutional layers, so that the model performs better on multi-scale objects. The article innovatively uses the DeepLab V3+ algorithm to generate the grasp strategy of a target and optimizes the atrous convolution parameter values of ASPP. This study used the Cornell Grasp dataset to train and verify the model. At the same time, a smaller and more complex dataset of 60 was produced according to the actual situation. Upon testing, good experimental results were obtained.
Sex, Bugs and Rock ‘n’ Roll: Insects in Music Videos
Authors: Coelho Joseph R.
Published: July 2021

The appearance of insects in music videos was examined. The most common taxa observed were Lepidoptera, then Hymenoptera, with Coleoptera, Araneae, Diptera, and Orthoptera essentially tied for third most represented. Insect music videos have increased in frequency over time, probably as an artifact of industry growth. Swarms and infestations were common in insect videos (appearing in 26%), as were chimeric insectoid humans (19%), and, to a lesser extent, giant insects (5%), but not all of these representations were used to induce horror. Some insect music videos have garnered awards, and many of the songs associated with them have been very successful. There were many animated insect sequences, but also images of specimens that were sufficiently detailed to allow identification of the species. The insect groups observed reflect both positive and negative values. There is some indication that insects are not viewed in such a negative light as they once were, providing hope for improving attitudes of humans toward insects.
The Combination of Chest Computed Tomography and Standard Electrocardiogram Provides Prognostic Information and Pathophysiological Insights in COVID-19 Pneumonia
Authors: Bertini Matteo , D’Aniello Emanuele , Cereda Alberto , Toselli Marco , Verardi Filippo Maria , Rossi Luca , Aschieri Daniela , Monello Alberto , Manfrini Marco , Vignale Davide , Palmisano Anna , Esposito Antonio , Ferrari Roberto , Rapezzi Claudio , Giannini Francesco
Published: July 2021

Aims. Several studies have unveiled the great heterogeneity of COVID-19 pneumonia. Identification of the “vascular phenotype” (involving both pulmonary parenchyma and its circulation) has prognostic significance. Our aim was to explore the combined role of chest computed tomography (CT) scan and electrocardiogram (ECG) at hospital admission in predicting short-term prognosis and to draw pathophysiological insights. Methods and Results. We analyzed the chest CT scan and ECG performed at admission in 151 consecutive COVID-19 patients admitted between 20 March and 4 April 2020. All-cause mortality within 30 days was the primary endpoint. Median age was 71 years (IQR: 62–76). Severe pneumonia was present in 25 (17%) patients, and 121 (80%) had abnormal ECG. During a median follow-up of 7 days (IQR: 4–13), 54 (36%) patients died. Deceased patients had more severe pneumonia than survivors did (80% vs. 64%, p = 0.044). ECG in deceased patients showed more frequently atrial fibrillation/flutter (17% vs. 6%, p = 0.039) and acute right ventricular (RV) strain (35% vs. 10%, p < 0.001), suggesting the “vascular phenotype”. ECG signs of acute RV strain (HR 2.46, 95% CIs 1.36–4.45, p = 0.0028) were independently associated with all-cause mortality in multivariable analysis, and in the likelihood ratio test, showed incremental prognostic value over chest CT scan, age, and C-reactive protein. Conclusions. Combining chest CT scan and ECG data improves risk stratification in COVID-19 pneumonia by identifying a distinctive phenotype with both parenchymal and vascular damage of the lung. Patients with severe pneumonia at chest CT scan plus ECG signs of acute RV strain have an extremely poor short-term prognosis.
The Prognostic Value of Low Muscle Mass in Pancreatic Cancer Patients: A Systematic Review and Meta-Analysis
Authors: Pierobon Elisa Sefora , Moletta Lucia , Zampieri Sandra , Sartori Roberta , Brazzale Alessandra Rosalba , Zanchettin Gianpietro , Serafini Simone , Capovilla Giovanni , Valmasoni Michele , Merigliano Stefano , Sperti Cosimo
Published: July 2021

Low muscle mass is associated with reduced survival in patients with different cancer types. The interest in preoperative sarcopenia and pancreatic cancer has risen in the last decade as muscle mass loss seems to be associated with poorer survival, higher postoperative morbidity, and mortality. The aim of the present study was to review the literature to compare the impact of low muscle mass on the outcomes of patients undergoing surgery for pancreatic adenocarcinoma. An extensive literature review was conducted according to the 2009 Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and 10 articles were analyzed in detail and included in the meta-analysis. Data were retrieved on 2811 patients undergoing surgery for pancreatic cancer. Meta-analysis identified that patients with low muscle mass demonstrated a significantly reduced OS when compared to patients without alterations of the muscle mass (ROM 0.86; 95% CI: 0.81–0.91, p < 0.001), resulting in a 14% loss for the former. Meta-analysis failed to identify an increase in the postoperative complications and length of stay of patients with low muscle mass. Our analysis confirms the role of low muscle mass in influencing oncologic outcomes in pancreatic cancer. Its role on surgical outcomes remains to be established.
Pre-Stroke Statin Therapy Improves In-Hospital Prognosis Following Acute Ischemic Stroke Associated with Well-Controlled Nonvalvular Atrial Fibrillation
Authors: Wańkowicz Paweł , Staszewski Jacek , Dębiec Aleksander , Nowakowska-Kotas Marta , Szylińska Aleksandra , Turoń-Skrzypińska Agnieszka , Rotter Iwona
Published: July 2021

Many studies have confirmed the positive effect of statins in the secondary prevention of ischemic stroke. Although several studies have concluded that statins may also be beneficial in patients with atrial fibrillation-related stroke, the results of those studies are inconclusive. Therefore, the aim of this study was to analyze the effect of pre-stroke statin therapy on atrial fibrillation-related stroke among patients with a well-controlled atrial fibrillation. This retrospective multicenter analysis comprised 2309 patients with acute stroke, with a total of 533 patients meeting the inclusion criteria. The results showed a significantly lower neurological deficit on the National Institutes of Health Stroke Scale at hospital admission and discharge in the group of atrial fibrillation-related stroke patients who took statins before hospitalization compared with those who did not (p < 0.001). In addition, in-hospital mortality was significantly higher in the atrial fibrillation-related stroke patients not taking statins before hospitalization than in those who did (p < 0.001). Based on the results of our previous research and this current study, we postulate that the addition of a statin to the oral anticoagulants may be helpful in the primary prevention of atrial fibrillation-related stroke.
New Trends and Advances in Non-Variceal Gastrointestinal Bleeding—Series II
Authors: Cañamares-Orbís Pablo , Lanas Arbeloa Ángel
Published: July 2021

The gastrointestinal tract is a long tubular structure wherein any point in the mucosa along its entire length could be the source of a hemorrhage. Upper (esophagel and gastroduodenal) and lower (jejunum, ileum, and colon) gastrointestinal bleeding are common. Gastroduodenal and colonic bleeding are more frequent than bleeding from the small bowel, but nowadays the entire gastrointestinal tract can be explored endoscopically and bleeding lesions can be locally treated successfully to stop or prevent further bleeding. The extensive use of antiplatelet and anticoagulants drugs in cardiovascular patients is, at least in part, the cause of the increasing number of patients suffering from gastrointestinal bleeding. Patients with these conditions are usually older and more fragile because of their comorbidities. The correct management of antithrombotic drugs in cases of gastrointestinal bleeding is essential for a successful outcome for patients. The influence of the microbiome in the pathogenesis of small bowel bleeding is an example of the new data that are emerging as potential therapeutic target for bleeding prevention. This text summarizes the latest research and advances in all forms of acute gastrointestinal bleeding (i.e., upper, small bowel and lower). Diagnosis is approached, and medical, endoscopic or antithrombotic management are discussed in the text in an accessible and comprehensible way.
Detection of Minor and Major Depression through Voice as a Biomarker Using Machine Learning
Authors: Shin Daun , Cho Won , Park C. , Rhee Sang , Kim Min , Lee Hyunju , Kim Nam , Ahn Yong
Published: July 2021

Both minor and major depression have high prevalence and are important causes of social burden worldwide; however, there is still no objective indicator to detect minor depression. This study aimed to examine if voice could be used as a biomarker to detect minor and major depression. Ninety-three subjects were classified into three groups: the not depressed group (n = 33), the minor depressive episode group (n = 26), and the major depressive episode group (n = 34), based on current depressive status as a dimension. Twenty-one voice features were extracted from semi-structured interview recordings. A three-group comparison was performed through analysis of variance. Seven voice indicators showed differences between the three groups, even after adjusting for age, BMI, and drugs taken for non-psychiatric disorders. Among the machine learning methods, the best performance was obtained using the multi-layer processing method, and an AUC of 65.9%, sensitivity of 65.6%, and specificity of 66.2% were shown. This study further revealed voice differences in depressive episodes and confirmed that not depressed groups and participants with minor and major depression could be accurately distinguished through machine learning. Although this study is limited by a small sample size, it is the first study on voice change in minor depression and suggests the possibility of detecting minor depression through voice.
Determinants of Longitudinal Change of Glycated Hemoglobin in a Large Non-Diabetic Population
Authors: Su Ho-Ming , Lee Wen-Hsien , Chen Ying-Chih , Liu Yi-Hsueh , Huang Jiun-Chi , Wu Pei-Yu , Chen Szu-Chia
Published: July 2021

Although many cross-section studies have assessed the determinants of glycated hemoglobin (HbA1c), there have been limited studies designed to evaluate the temporal correlates of HbA1c in non-diabetic patients. This study aimed to identify the major determinants of longitudinal change of HbA1c in non-diabetic patients. This study included subjects from the 104,451 participants enrolled between 2012 and 2018 in the Taiwan Biobank. We only included participants with complete data at baseline and follow-up (n = 27,209). Patients with diabetes at baseline or follow-up (n = 3983) were excluded. Finally, 23,226 participants without diabetes at baseline and follow-up were selected in this study. △Parameters was defined as the difference between the measurement baseline and follow-up. Multivariable linear regression analysis was used to identify the major determinants of HbA1c longitudinal change (△HbA1c). During a mean 3.8 year follow-up, after multivariable analysis, new-onset hypertension (coefficient β: 0.014, p < 0.001), high △heart rate (coefficient β: 0.020, p = 0.002), high △BMI (coefficient β: 0.171, p = 0.028), high △fasting glucose (coefficient β: 0.107, p < 0.001), low △creatinine (coefficient β: −0.042, p < 0.001), high △total cholesterol (coefficient β: 0.040, p < 0.001), high △hemoglobin (coefficient β: 0.062, p < 0.001), high △GPT (coefficient β: 0.041, p = 0.001), and low △albumin (coefficient β: −0.070, p < 0.001) were significantly associated with high △HbA1c. In non-diabetic population, strategies to decrease the development of new-onset hypertension, resting heart rate, body mass index, fasting glucose, total cholesterol, and GPT and increase serum albumin level might be helpful in slowing the longitudinal change of HbA1c. In addition, increased hemoglobin and decreased serum creatinine over time also had an impact on the HbA1c elevation over time in non-diabetic population.
Calculation of Ecological Compensation Standards for Arable Land Based on the Value Flow of Support Services
Authors: Bai Yunxiao , Liu Moucheng , Yang Lun
Published: July 2021

Food production is the basis for ensuring human survival. Ecological compensation for arable land is important to ensure the sustainable use of arable land and food production. However, how is it possible to set the standard of ecological compensation and how to achieve it scientifically? In this paper, we take China as the study area and link the ecological compensation of arable land with the production, circulation and consumption of three staple foods. The amount of food is converted into the area of arable land needed to produce that food. After calculating the value of ecosystem services that support food production on arable land, the ecological compensation standard is obtained, and the realization mode between regions is constructed. The results show that: (1) the flow of staple foods in China is mainly from north to south and the value of arable land support services provided by northern provinces is greater than that of southern provinces; (2) the province that needs to pay the most ecological compensation for cultivated land is Guangdong Province, with an amount of ¥16.082 billion RMB, and the province that receives the most compensation is Heilongjiang Province, with an amount of ¥21.547 billion RMB; (3) in order to coordinate the collection and distribution of ecological compensation in each province, it is necessary to establish an ecological compensation fund for arable land in the central government. Protecting the ecological status of arable land and ensuring sustainable food production is in the overall interest of the country.