bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of the Corrosion Resistance of WC-Co Coating on AZ91 Applied by Electro Spark Deposition
Authors: Tabrizi Arvin Taghizadeh , Pouzesh Maryam , Laleh Farhad Farhang , Aghajani Hossein
Published: August 2021

In order to enhance the surface properties of a magnesium-based substrate, WC-Co coating was applied on AZ91 alloy by electro spark deposition (ESD), successfully for the first time. The optimum parameters of the ESD process were achieved, based on the corrosion behavior and calculated corrosion rate of the coated samples when 5kHz and 25 A were chosen. For evaluation of the corrosion performance of the achieved WC-Co layers, polarization, and electrochemical impedance spectroscopy tests were carried out in the 3.5 wt % Na3PO4 solution at room temperature. Polarization results show that the corrosion rate (mpy) is in the optimum condition almost half of a bulk sample of uncoated AZ91. Field emission scanning electron microscopy (FE-SEM) was used to examine the surface morphology of applied coatings. These results show that at a lower current, the amount of deposited WC-Co was reduced. The maximum surface microhardness obtained was 193 HV0.2.
Essentials in the diagnosis of postoperative myocardial lesions similar to or unrelated to rejection in heart transplant
Authors: Dumitru Costel , Zazgyva Ancuta , Habor Adriana , Cotoi Ovidiu , Suciu Horațiu , Cotrutz Carmen , Grecu Bogdan , Sin Ileana Anca
Published: August 2021

Background, objectives: Histological diagnosis of control biopsies in patients with heart transplant represents a significant step of monitoring, with a great influence on adjusting immunosuppressive treatment. Histological lesions are usually related to ischemia and reperfusion, with varying degrees of intensity. This study aimed to highlight the most important aspects of the histological diagnosis and differential diagnosis of postoperative myocardial lesions associated or unrelated to rejection in heart transplant.

Materials and Methods: This retrospective study involved 53 patients who received cardiac transplant between 2000 and 2017. Patients were monitored by lesion quantification of endomyocardial biopsies, with diagnoses established based on biopsy material in the early, medium and late post-transplant periods. Hematoxylin eosin, Masson’s trichrome, and Van Gieson stains were used; immunohistochemical determinations used CD4, CD20, CD45, CD68, HLA-DR, VEGF and CD31.

Results: Ischemia and reperfusion lesions were diagnosed on all biopsies in the first 6 weeks post-transplant. Nine cases of the Quilty effect were identified, and in 12 cases, the biopsies were performed on the same spot as previous biopsies. A significant number of transplanted patients presented cytomegalovirus that was difficult to diagnose on endomyocardial biopsies.

Conclusions: The detailed study of ischemia and reperfusion lesions, as well as of changes un-related to rejection becomes a major objective in the short, medium and late post-transplant period. Overdiagnosis of rejection induces changes of the immunosuppressive therapeutic protocol, with alarming repercussions on cytomegalovirus reactivation, and risks of potentiating inflammation, myocyte destruction and the recurrence of disorders related to both inducing and aggravating heart failure.
The “Aum Incident” as a Catalyst for Societal Critique: An Analysis of Letters to the Editor of Asahi Shinbun on Aum Shinrikyō
Authors: Mayer Patricia Sophie
Published: August 2021

This article analyses the discussion of Aum Shinrikyō in letters to the editor of one of the major Japanese newspapers, Asahi Shinbun, through the method of qualitative content analysis. The examination focuses on two aspects of the letters in order to uncover how Aum is understood and localised in a bigger context: first, how Aum itself is discussed, and second, what topics are brought up in relation to the group. The analysis reveals that Aum was rarely referred to as a cult or a false religion, but more often merely as a religion, which is subsequently associated with negative notions. The majority of letters, however, did not specify the nature of Aum at all. This is congruent with the topics covered in the letters, since the content of a large portion of them is not concerned with Aum directly but with a more abstract critique of society and authorities. Letters to the editor of Asahi Shinbun for a large part do not make use of sensationalist wording, all the while expressing a critical stance towards the movement, and additionally they focus on a critique of the dealings with Aum prior to and after the subway attack in 1995.
Human Response to Flood Disaster in Kandawalai in Kilinochchi District in Sri Lanka
Authors: Yushanthi Y. , Rekha Nianthi K.W.G.
Published: August 2021

The flood is one of the extreme weather events in the world. In Sri Lanka, it is a major natural disaster that mainly occurs in the South-West and the North-East monsoon seasons. The human response strategies are explained in the concepts of the disaster management cycle in the PRE and POST stages. People do not satisfactorily respond during these stages in the study area. There have been no systematic studies conducted on how people responded before, during, and after the floods in Kandawalai. The main objective of this study was to examine human responses to PRE flood situations (mitigation and preparedness). This study selected three GN divisions. Questionnaires, surveys, and interviews were carried out to collect primary data and information. The data was analyzed using both quantitative and qualitative methods. Some preparedness and mitigation were undertaken by the Disaster Management Centre (DMC) in Kilinochchi during the PRE flood stage. To reduce floods, the community has used very simple community-based mitigation measures. Only 43% of them took part in flood-awareness programs that taught them how to evacuate from flood-prone areas and how to respond to early warning systems.57% of respondents mentioned that the flood impact could be reduced through better structural mitigation strategies. 10% of the respondents recommended controlling the illegal activities of sewage disposal and soil mining in the Kanakarayan River. The PRE-flood activities should be considered by relevant stakeholders together with community participation, but the government has the main responsibility for mitigating the impacts of the floods in this particular area.
Fire Disaster Preparedness among Residents in a High Income Community
Authors: Valentine Ngwoke Nwora , Bolaji Wahab Akeem
Published: August 2021

Fire disaster preparedness (FDP) is of paramount importance in preventing the globe’s most prevalent disaster. This has been a big issue for developing nations. The study investigated FDP among residents in a high-income community of a part in Southwestern Nigeria. The aim of the study was to identify the preparedness of residents regarding fire disasters in residential buildings in Parakin, Ife Central Local Government Area of Osun State, Nigeria. To achieve the objectives, a quantitative study was carried out, primary data was sourced from structured, self-administered questionnaires. 80 buildings was purposively selected for the study. Affiliated literature was reviewed. Descriptive statistical tools such as frequency distribution and percentage was used in analysing the data. Chi-square tests at a significance level of 0.05 was done. SPSS version 23.0 was used in analysing all the data. Findings revealed that FDP is very low in the study area as respondents have very little or no firefighting facilities or gadgets, awareness, training about FDP. Chi-square tests revealed that there was no statistical significance between age of respondents and preparedness, ownership of home and preparedness, education and preparedness and sex and preparedness. It was established that preparedness for fire is very low. The study, however, recommended the provision of active and passive fire protection facilities in buildings, proper training of building users on FDP, enabling laws are also needed to promote the installation of fire protection, prevention, detection and suppression.
INVESTIGATION OF THE DIFFUSION OF CARBONYL COMPOUNDS IN THE TECHNOLOGY OF SMOKING MUSK DUCK ON AN EXPERIMENTAL INSTALLATION WITH THE USE OF OVERPRESSURE AND VAPORS OF SPICY-SMOKY FLAVORS
Authors:   Voronezh State University of Engineering Technologies, Sukharev I.N. , Zhuravlev A.V. ,   Voronezh State University of Engineering Technologies, Shakhov S.V. ,   Voronezh State University of Engineering Technologies
Published: August 2021

In recent years, the interest of researchers in smoked products has increased, primarily as a source of protein food. At the same time, the task of developing all new types of original smoked prod-ucts is very urgent. One of the promising directions in this area is to expand the product range by changing and improving their taste, aroma and shelf life by smoking the product with smoky fla-vors. Therefore, to solve the problems associated with ensuring high smoking efficiency, it is nec-essary to develop a method that ensures the penetration of smoking particles into the product by eliminating limiting factors in their path. The presented method for producing smoked musk duck with the use of overpressure and vapors of spicy-smoky flavors fully meets the modern develop-ment of the food industry. The article presents the results of the study of the diffusion of carbonyl compounds into the product thickness in an experimental setup. These studies confirm the feasi-bility of using excessive pressure when smoking musk duck.
THE MOST COMMON ORGANISMS ARE BIOINDICATORS OF SOIL FERTILITY IN THE NORTH OF THE CENTRAL CHERNOZEM REGION
Authors:   Bunin Yelets State University, Zakharov V.L.
Published: August 2021

The research was conducted in the Tambov and Lipetsk regions. A comparative assessment of the sensitivity of the most common and publicly available bioindicators of soils in the northern part of the Central Chernozem region was carried out. Among cereals and leguminous crops, simply and alfalfa are very sensitive to changing the acidity of the soil. From cruciferous vegetable plants, lettuce and radish react well to the formation of humus-rich soils and the change of soil type in the rosette phase during the growth of the root crop (the biochemical composition of the root crop changes). Leaf lettuce and spinach react sensitively not only to the type of nitrogen ferti-lizer, the presence of chlorine, but also to the dose of nitrogen for the active substance. The cu-cumber reacts sensitively to different levels of easily hydrolyzed nitrogen in the soil by the time the first whiskers are formed. Winter cereals (wheat and triticale) are good bioindicators for dif-ferent soil bonuses and their biomass shows a different attitude to the soil from two zones of apple orchards – row spacing and trunk strips. Barley is also responsive to soil bonitet. All its above-ground organs change the content of the common forms of nitrogen, phosphorus and potassium when the soil conditions change, and only in the ear of these elements of nutrition remain in the optimal range. Apple seedlings with their aboveground biomass, the number of leaves and their water regime react to changes in the properties of the humus horizon, soil fatigue and the change of the soil horizons themselves. In response to an increase in the content of humus, potassium, and manganese in the soil and a change in pHKCl in the leaves of clonal apple rootstocks PB-9 and 62-396, the amount of potassium, phosphorus, calcium, and magnesium changes. Rootstock 62-396 sensitively changes the content of anthocyanins, chlorophyll and carotenoids in the leaves in re-sponse to the change in soil type. Yeast and mold fungi reduce their number when the pesticide load on the soil increases. The complex of cellulose-decomposing soil microorganisms reacts sen-sitively to the change of the soil horizon, soil type and anthropogenic transformation during the development of land for apple orchards.
IMPROVING THE RELIABILITY OF TRAILED DUMP VEHICLES
Authors:   Bunin Yelets State University, Ibragimov E.V.
Published: August 2021

Increasing the productivity and efficiency of agricultural cargo transportation in the agro-industrial complex of the Russian Federation is achieved through the use of tractor trains consist-ing of tractors and trailer links, the main of which are trailers. This method allows you to ensure the quality and safety of agricultural goods, as well as reduce the cost of transportation. During the analysis of the known designs of tractor-trailer dump trailers, it was revealed that a character-istic drawback is the imperfection of the design of the locking elements of the platforms designed to fix them on the chassis. As a result, a promising technical solution was developed, which, in comparison with the known ones, has a simple design and increased efficiency when fixing the bodies on the chassis. The article describes the design and the principle of operation of this tech-nical solution. The results of the structural strength calculation are presented. The conducted check showed that the obtained value of the safety factor, equal to 2.2, will ensure the operational reliability of trailed dump vehicles. The results of the study are recommended to both domestic and foreign research institutes, design and production structures of the automotive industry for further study and refinement of the proposed device with a view to its possible implementation in practice.
BİST Banka Endeksi ile Makroekonomik Değişkenler Arasındaki İlişkinin Bootstrap ve Asimetrik Nedensellik Analizleri ile İncelenmesi
Authors: KUZU YILDIRIM Sultan
Published: August 2021

Ekonomik değişkenler arasındaki dinamik ve karmaşık ilişki araştırmacıların her zaman ilgi odağı olmuştur. Bu çalışmada BİST Banka, Döviz Kuru, Altın Fiyatları (ons) ve Gayri Safi Yurt İçi Hasıla (GSYİH) arasındaki ilişki ampirik olarak incelenmektedir. Bu amaçla 2002/Q1 ve 2019/Q4 arasındaki dönem ele alınarak değişkenler arasındaki ilişki Hacker & Hatemi-J (2006) bootstrap nedensellik analizi ve Hatemi-J (2012) asimetrik nedensellik analizi ile test edilmiştir. Serilerin durağanlık dereceleri, öncelikle ADF ve KPSS birim kök testleri ile ardından yapısal kırılmaları göz önüne alan LS (2004) testi ile belirlenmiştir. Bootstrap nedensellik analizine göre %5 anlamlılık düzeyinde sadece GSYİH’dan BİST Banka’ya doğru tek yönlü nedensellik olduğu saptanmıştır. Asimetrik nedensellik analizinin sonuçlarına göre dolar kurundaki negatif yönlü bir şokun, BİST Banka’daki pozitif yönlü şokun nedeni olduğu, BİST Bankadaki pozitif yönlü şokun, GSYİH’daki pozitif yönlü şokun nedeni olduğu gözlenmiştir. Ayrıca BİST Banka ve altın fiyatları arasındaki nedensellik incelendiğinde, altın fiyatlarındaki pozitif yönlü şokun, BİST Banka’nın hem pozitif hem de negatif yönlü şoklarının nedeni olduğu belirlenmiştir.
On the Direct Product of Intuitionistic Fuzzy Topological d-algebra
Authors: Hasan Ali Khalid
Published: August 2021

we applied the direct product concept on the notation of intuitionistic fuzzy semi d-ideals of d-algebra with investigation some theorems, and also, we study the notation of direct product of intuitionistic fuzzy topological d-algebra.
A Tool to Automate Student UML diagram Evaluation
Authors: Modi Salisu , Taher Hanan Abdulrahman , Mahmud Hoger
Published: August 2021

Unified modelling language (UML) is the accepted standard and modelling language for modeling in software development process. UML is widely used by most course tutors in teaching modules of software engineering and system analysis and design. Students taking such courses do submit assignments with UML diagrams such as use case, class, sequence, activity and so on. Different versions of such diagrams produced by the students for a given problem have to be assessed by the course tutor which is a challenging and time-consuming task. This paper presents a java-based tool which is developed based on a simple yet effective algorithm developed by the authors that will read student and tutors solution diagrams as inputs and evaluate and grade the diagrams automatically. The output of the tool is the score of the student diagram in respect of lecturer’s final solution. The output is presented in two feedback files, one containing students’ score for the lecturers and the other to be send to the student to note the areas that were incorrect. The tool has been tested and evaluated using a simple and assumed UML class diagram. The result shows that the tool functions effectively and can produce detail feedbacks for both students and tutors. The outcome of this paper contributes towards automating UML diagram evaluations.
The Texas Legislature Has Significantly Broadened the Statute Governing Recovery of Attorney's Fees in Breach of Contract Cases
Authors: Crespi Gregory , Bakke West
Published: August 2021

Texas recently enacted amendments that significantly expand the scope of section 38.001 of the Texas Civil Practice & Remedies Code, a statute that awards attorney’s fees to successful claimants in breach of contract cases. Under the new amendments, which take effect September 1, 2021, the prevailing party may recover reasonable attorney’s fees from most forms of business organizations, including partnerships and limited liability companies—not just from individuals and corporations, as the statute previously provided. And although there has been some confusion on this point, the amended statute continues to protect governments and governmental agencies from attorney’s fees liability. Additionally, the amendments expressly preclude recovery of fees against certain quasi-governmental organizations providing public services and religious or charitable organizations.
Research Progress: Instituto De Investigaciones En Ciencias Biomédicas (INICIB), Universidad Ricardo Palma
Authors: De La Cruz-Vargas Jhony A. , Rodríguez Chávez Elio Iván
Published: August 2021

One of the essential functions of the university is to promote, support and strengthen research, as a source to generate new knowledge and as a scientific tool in search of practical solutions to everyday problems in society. The Universidad Ricardo Palma, represented by their dean as its highest authority, offers the university’s academic framework and the institution’s policies will in order to move forward in research policies.
Confounding: Linking Evidence to Practice
Authors: Kamper Steven J.
Published: August 2021

A confounder is a variable that influences the relationship between an exposure and an outcome. This means that a difference in outcome is not only explained by the factor that we think explains it (the exposure), but also (completely or partly) by another factor (the confounder). Confounding underpins the hackneyed expression, “Correlation does not imply causation.” Your assessment of a study's risk of confounding should inform how much confidence you have in the results.

J Orthop Sports Phys Ther 2021;51(8):412–413. doi:10.2519/jospt.2021.0702
Lingual split bone technique – Revisited as a standard operating procedure for surgical removal of third molar during COVID pandemic
Authors: Mohan Sushmitha , Thangavelu Annamalai , Aravindraj
Published: August 2021

Objectives:

The objective of the study is to revisit the forgotten art of Lingual split bone technique during the COVID pandemic as a Standard Operating Procedure (SOP) for the surgical removal of impacted mandibular third molars. It was originally introduced in early 90’s by Sir William Kelsey Fry and also we have compared its advantages over the bone guttering technique.

Materials and Methods:

Twenty seven cases were operated during COVID pandemic in our institution using Davi’s modified lingual split technique under strict COVID protocol.

Results:

All impacted mandibular third molars were successfully removed. With regards to post-operative complication; 3 patients had nerve injury (11%), 2 patients had lingual paraesthesia (7.6%), 1 patient had alveolar osteitis (3.8%), 2 patients had postoperative infection (7.6%), 3 patients had trismus (19%). The overall success rate was 100%. Also the results of a comparison between bone guttering and chisel-mallet technique were stated.

Conclusion:

The use of lingual split bone technique deserves consideration during this COVID time as an alternate for bone guttering in surgical removal of third molar as it ensures minimal cross infectivity rate among both dentists and patients. Thus, patient care can be delivered with confidence even during pandemic.
Contribution of risk factors in the development of chronic pancreatitis in carriers of rs213950 CFTR
Authors: Самгина Т.А. , Колмыков Д.И. , Мяснянкина Г.Н. , Горбунов С.М. , Азарова Ю.Э. , Канищев Ю.В. , Бондарев Г.А. , Назаренко П.М. , Полоников А.В. , Лазаренко В.А.
Published: August 2021

К настоящему времени сложились представления о мультифакториальной природе панкреатита, в развитии которого играют роль, как генетические факторы, так и факторы окружающей среды. Цель: определить вклад некоторых факторов риска и полиморфного локуса rs213950 гена СFTR в развитие хронического панкреатита. Исследованы образцы ДНК, полученные от 302 неродственных больных хроническим панкреатитом и 465 неродственных индивидов без заболеваний ЖКТ. Генотипирование выполнено методом ПЦР с дискриминацией аллелей с помощью TaqMan-зондов. Для оценки ассоциаций аллелей и генотипов генов с риском развития заболевания использовали критерий χ2 и отношение шансов (OR) с 95% доверительными интервалами (CI). В ходе проведенного исследования обнаружена ассоциация аллеля А rs213950 гена СFTR с повышенным риском развития хронического панкреатита (OR=1,24, CI 95%=1,01-1,53, p=0,04). У курящих носителей генотипов A/G-A/A (OR=2,07, CI 95%=1,13-3,78, p=0,017D) и при злоупотреблении алкогольными напитками более 10 лет у носителей генотипа А/А (OR=2,23, CI 95%=1,12-4,47, р=0,02R) риск развития хронического панкреатита повышался.

Chronic pancreatitis is the multifactorial disease, genetic and environmental factors play a role in the development of it. The aim was to determine the contribution of rs213950 CFTR gene to the risk of chronic pancreatitis (CP). DNA samples obtained from 302 unrelated patients with chronic pancreatitis and 465 unrelated individuals without gastrointestinal diseases. Genotyping was performed using the PCR method with discrimination of alleles using TaqMan probes. The χ2 criterion and the odds ratio (OR) with 95% confidence intervals (CI) were used to assess the associations of alleles and genotypes of genes with the risk of the disease. We found an association of the A allele rs213950 of the CFTR gene with an increased risk of chronic pancreatitis (OR=1,24, CI 95%=1,01-1,53, P=0,04). Also, the risk of CP increased in smokers with the A/G-A/A genotypes (OR=2,07, CI 95%=1,13-3,78, P=0,017D) and with alcohol abuse for more than 10 years in carriers of the A/A genotype (OR=2,23, CI 95%=1,12-4,47, P=0,02R). The frequency and volume of alcohol consumed in carriers of the rs213950 polymorphism of the CFTR gene didn’t reveal statistically significant differences.
Molecular genetic diagnostics of Bardet-Biedl syndrome with an MPS-panel
Authors: Орлова М.Д. , Гундорова П. , Поляков А.В.
Published: August 2021

Синдром Барде-Бидля - аутосомно-рецессивное заболевание, характеризующееся ожирением, пигментной дегенерацией сетчатки, полидактилией, задержкой психоречевого развития и структурными повреждениями почек. В работе представлены результаты применения МПС-панели, включающей кодирующие последовательности и прилегающие интронные области 21 гена, ассоциированного с синдромом Барде-Бидля. Впервые была проведена молекулярно-генетическая диагностика в группе из сорока российских пациентов с синдромом Барде-Бидля из неродственных семей. В результате исследования удалось подтвердить диагноз молекулярно-генетическим методом у 40% пациентов (n=16). В генах BBS1, BBS7 и BBS10 встретились повторяющиеся варианты. Частота встречаемости патогенных и вероятно патогенных вариантов в генах BBS1 и BBS10 у российских пациентов соответствует зарубежным данным. Варианты в гене BBS7 встретились у пяти человек, у четырех из них был обнаружен патогенный вариант c.1967_1968delTAinsC, не встречающийся в других популяциях. Результаты, представленные в статье, показывают значительный вклад в заболеваемость синдромом Барде-Бидля в российской популяции патогенных вариантов в гене BBS7.

Bardet-Biedl syndrome is an autosomal recessive disorder characterized by obesity, retinitis pigmentosa, polydactyly, development delay, and structural kidney defects. This study shows the results of using an MPS panel that includes coding sequences and intronic areas of 21 genes associated with Bardet-Biedl syndrome. For the first time molecular genetic testing has been provided for the group of 40 Russian patiens with Bardet-Biedl syndrome from unrelated families. As a result of the testing, diagnoses were confirmed for 40% of the patients (n=16). The genes BBS1, BBS7, BBS10 had recurrent variants. The frequency of pathogenic and likely pathogenic variants in the genes BBS1 and BBS10 among Russian patients matches the research data in other countries. Variants in the BBS7 gene were found for five people, four of them had a pathogenic variant c.1967_1968delTAinsC, which is not present among other populations. Results provided in this article show the significant role of pathogenic variants in the BBS7 gene in patients with Bardet-Biedl syndrome in Russian population.
A case of deletion 8q22.2q22.3 in a child with de novo balanced translocation t(1;6)
Authors: Миньженкова М.Е. , Маркова Ж.Г. , Анисимова И.В. , Канивец И.В. , Шилова Н.В.
Published: August 2021

Выяснение этиопатогенеза аномального фенотипа у пациентов со сбалансированными транслокациями является актуальным аспектом в современной клинической цитогенетике. Формирование аномалий развития может быть ассоциировано с наличием скрытого геномного дисбаланса как в точках разрывов, так и на хромосомах, не задействованных в перестройке. Целью данного исследования явилась этиологическая диагностика геномного дисбаланса у пациента со сбалансированной транслокацией и аномалиями развития. Для детекции геномного дисбаланса у пациента со сбалансированной транслокацией использовали хромосомный микроматричный анализ (ХМА) и FISH-исследование. У пациента со сбалансированной транслокацией при ХМА была выявлена делеция на хромосоме 8, не задействованной в транслокации. Таким образом, в статье представлен новый случай делеции 8q22.2q22.3 у пациента со сбалансированной транслокацией t(1;6) и аномалиями развития вследствие делеции.

Identification of the etiopathogenesis of the abnormal phenotype in patients with balanced translocations is current trend in cytogenetic laboratories. The formation of developmental anomalies can be associated with the presence of a cryptic genomic imbalance both at breakpoints and on chromosomes not involved in rearrangements.The aim of this study is diagnostics of genomic imbalance in a patient with balanced translocation and abnormal phenotype. The case was characterized by GTG-banding, chromosomal microarray analysis and FISH diagnosis. We present a new case of deletion 8q22.2-q22.3 in child with balanced translocation t(1;6) and developmental delay/congenital defects due to deletion.
Gene polymorphisms associated with the remodeling of the connective tissue as markers of preclinical diagnosis of primary open-angle glaucoma in patients with hereditary predisposition
Authors: Кириллова М.О. , Журавлева А.Н. , Марахонов А.В. , Петрова Н.В. , Балинова Н.В. , Зинченко Р.А. , Кадышев В.В.
Published: August 2021

Цель исследования - изучение взаимосвязи полиморфизмов генов, кодирующих структуру регуляторных белков синтеза и деградации экстрацеллюлярного матрикса соединительной ткани, с развитием первичной открытоугольной глаукомы (ПОУГ). Обследовано 144 человека (мужчин - 56, женщин - 88), средний возраст 59,3±6,2, не состоящих в родстве, русской национальности. Группу I составили 40 человек с подозрением на глаукому, в группу II вошли 40 человек с диагнозом ПОУГ I-II стадий на одном или обоих глазах. Пациенты обеих групп имели отягощенный семейный анамнез по глаукоме. Группу контроля составили 64 относительно здоровых человека. Всем пациентам проведены стандартные и специальные офтальмологические, а также молекулярно-генетические исследования. Носительство генотипа GT и аллеля Т полиморфизма rs8136803 (TIMP3), генотипа AG и аллеля A полиморфизма rs652438 (MMP12), генотипа GA и аллеля A полиморфизма rs3825942 (LOXL1) ассоциировано с развитием ПОУГ. Ассоциации полиморфизма rs1048661 гена LOXL1 с развитием ПОУГ не выявлено. Проведенное исследование указывает на необходимость формирования алгоритма обследования пациентов с ПОУГ и подозрением на глаукому с включением молекулярно-генетических исследований.

Objective: to study gene polymorphisms associated with the remodeling of the connective tissue of the eye as markers of preclinical diagnosis of primary open-angle glaucoma in patients with hereditary predisposition. Materials and methods: a total of 144 persons (56 men, 88 women), average age 59.3±6.2, were examined, not related, of Russian nationality. Group I consisted of 40 individuals suspected to affected by glaucoma, group II included 40 individuals with a diagnosis of I-II stage POAG in one or both eyes. Patients of both groups had a complicated family history of glaucoma. The control group consisted of 64 relatively healthy individuals. All patients underwent standard and special ophthalmological examination, as well as molecular genetic testing. Results: carriage of GT genotype and T allele of rs8136803 polymorphism (TIMP3), AG genotype and A allele of rs652438 polymorphism (MMP12), GA genotype and A allele of rs3825942 polymorphism (LOXL1) was associated with the development of POAG. The rs1048661 polymorphism of the LOXL1 gene cannot be considered as a marker of POAG development. Conclusion: the study indicates the need to develop a correct algorithm for diagnosing patients with POAG and suspected glaucoma with the inclusion of molecular genetic studies.
A modification of the CABARET scheme for numerical simulation of one-dimensional detonation flows using a one-stage irreversible model of chemical kinetics
Authors: Данилин А.В. , Соловьев А.В. , Зайцев А.М.
Published: August 2021

Представлен алгоритм для численного моделирования задач одномерной детонации с использованием одностадийной необратимой модели химической кинетики. Дискретизация уравнений движения произведена согласно балансно-характеристической методике ``кабаре''. Аппроксимация источниковых членов выполнена без расщепления по физическим процессам с использованием неявного подхода с регулируемым порядком аппроксимации. Показано точное согласование параметров моделируемой детонации Чепмена--Жуге с аналитическим решением. Для неустойчивой детонации продемонстрирована зависимость результатов расчета от порядка аппроксимации правых частей.

An algorithm for numerical simulation of one-dimensional detonation using a one-stage irreversible model of chemical kinetics is proposed. The discretization of the convective parts of governing equations is made in accordance with the
balance-characteristic CABARET (Compact Accurately Boundary Adjusting-REsolution Technique) approach. The approximation of source terms is performed implicitly without splitting into physical processes with a regulated order of approximation. It is shown that the numerically obtained Chapman-Jouget detonation parameters are in exact agreement with the analytical solution. It is also shown that, in the case of unstable detonation, the numerical results are dependent on the order of approximation chosen for the right-hand sides of the governing equations.
Inverse problems of layer-by-layer ultrasonic tomography with the data measured on a cylindrical surface
Authors: Серёжников С.Ю. , Романов С.Ю. , Гончарский А.В.
Published: August 2021

Статья посвящена разработке эффективных методов решения обратных задач волновой томографии. Предложена новая схема послойной томографии трехмерных объектов с экспериментальными данными, которые измеряются на цилиндрической поверхности. Такая схема обеспечивает измерение как отраженных, так и проходящих волн и легко реализуема на практике. Для решения обратной задачи используется математическая модель, которая хорошо описывает как дифракционные эффекты, так и эффект поглощения ультразвукового излучения. Предложены эффективные численные методы восстановления скоростного разреза по экспериментальным томографическим данным на цилиндрической поверхности. Разработанные методы ориентированы в первую очередь на диагностику рака молочной железы на ранних стадиях заболевания. Обратные задачи ультразвуковой томографии являются нелинейными и очень сложными с вычислительной точки зрения. Численные алгоритмы реализованы на графических процессорах. Эффективность разработанных алгоритмов иллюстрируется модельными расчетами.

This paper is dedicated to developing efficient methods to solve inverse problems of wave tomography. The proposed new scheme of layer-by-layer tomography of 3D objects uses the experimental data measured on a cylindrical surface. This scheme provides the measurements of both the reflected and the transmitted waves and can easily be implemented in practice. The mathematical model used to solve the inverse problem takes into account the ultrasound diffraction and absorption effects. The authors developed efficient numerical methods to reconstruct the sound speed cross section using the tomographic data measured on the cylindrical surface. These methods are aimed primarily at early breast cancer diagnosis. The inverse problems of ultrasonic tomography are nonlinear and very computationally expensive. The efficiency of the developed methods is illustrated via numerical simulations. The numerical algorithm is implemented on GPU.
Parallel computations on a hybrid computing system for two-phase filtration problems
Authors: Никифоров А.И. , Садовников Р.В.
Published: August 2021

Рассматривается применение параллельных вычислений для решения задач двухфазной фильтрации с большим количеством скважин на гибридной вычислительной системе, позволяющей использовать ядра центрального
процессора и ядра графического процессора.

The application of parallel computations to solve two-phase filtration problems with a large number of wells on a hybrid computer system is considered, which makes it possible to use the cores of the central processor and the cores of the graphics
processor.
A numerical method for solving the Oseen-type problem in an L-shaped domain
Authors: Рукавишников А.В.
Published: August 2021

Для задачи типа Озеена в вихревой форме в многоугольной области с входящим тупым углом на границе определено $R_{\nu}$-обобщенное решение. Для ее приближенного решения построен весовой метод конечных элементов. Численные эксперименты модельной задачи в $L$-образной области показали преимущества предложенного метода.

In this paper we introduce the notion of an $R_{\nu}$-generalized solution to the Oseen-type problem in rotation form in a polygonal domain with a reentrant obtuse angle on its boundary. We propose a weighted finite element method to solve this problem approximately. A number of numerical experiments performed on a model problem in an $L$-shaped domain show the advantages of the proposed method.
To the orthogonal expansion theory of the solution to the Cauchy problem for second-order ordinary differential equations
Authors: Арушанян О.Б. , Залеткин С.Ф.
Published: August 2021

Доказана теорема о разрешимости нелинейной системы уравнений относительно приближенных значений коэффициентов Чебышёва старшей производной, входящей в дифференциальное уравнение. Теорема является теоретическим обоснованием ранее предложенного приближенного метода интегрирования канонических систем обыкновенных дифференциальных уравнений второго порядка на основе ортогональных разложений с использованием многочленов Чебышёва первого рода.

A solvability theorem is proved for a nonlinear system of equations with respect to the approximate Chebyshev coefficients of the highest derivative in an ordinary differential equation. This theorem is a theoretical substantiation for the previously proposed
approximate method of solving canonical systems of second-order ordinary differential equations using orthogonal expansions on the basis of Chebyshev polynomials of the first kind.
Deformation of cylindrical cavities in plane-parallel potential flows with circulation and under the action of mass forces
Authors: Байков Н.Д. , Петров А.Г.
Published: August 2021

Рассматриваются задачи формирования кумулятивных струй в плоскопараллельных потенциальных течениях идеальной несжимаемой жидкости внутри цилиндрических полостей. На основе метода граничных элементов строится численный алгоритм решения. При аппроксимации используются квадратурные формулы без насыщения.
Новизна работы заключается в исследовании потенциальных течений с ненулевой циркуляцией и выводе аналога закона сохранения импульса для таких течений. Кроме того, рассматривается задача всплытия полости в тяжелой жидкости.

The problems of cumulative jet formation in plane-parallel potential flows of a perfect incompressible fluid within cylindrical cavities are considered. A new numerical algorithm is proposed on the basis of the boundary element method. The approximation is based on quadrature formulas without saturation. The novelty of this paper is to study the potential flows with nonzero circulation and to derive an analog of the momentum conservation law for such flows. The process of the cavity rise in a heavy fluid is also studied.
A method of damped absorption of electromagnetic waves in the numerical simulation of electron beam-plasma interaction
Authors: Берендеев Е.А. , Ефимова А.А.
Published: August 2021

Рассматривается затухающее поглощение в качестве граничного условия для решения уравнений Максвелла методом FDTD (Finite Difference Time Domain). С помощью численных экспериментов показана эффективность использования простого поглощающего слоя для поглощения электромагнитного излучения точечного источника. Показана эффективность использования данного метода для учета мощности электромагнитного излучения при численном моделировании взаимодействия электронного пучка с плазмой методом частиц в ячейках.

The damped absorption as a boundary condition for solving the Maxwell equations by the FDTD (Finite Difference Time Domain) method is considered. Numerical experiments confirm the efficiency of using a simple absorbing layer to absorb the electromagnetic radiation from a point source. The efficiency of using this method to take into account the power of electromagnetic radiation in the numerical simulation of electron beam-plasma interaction by the particle-in-cell method is also shown.
An efficient finite-difference method for solving Smoluchowski-type kinetic equations of aggregation with three-body collisions
Authors: Стефонишин Д.А. , Матвеев С.А. , Смирнов А.П. , Тыртышников Е.Е.
Published: August 2021

Рассмотрена модель агрегационных процессов для класса уравнений типа уравнений Смолуховского, допускающих
тройные взаимодействия агрегатов. Предложен численный метод быстрого решения задачи Коши для указанной системы уравнений, позволяющий снизить алгоритмическую сложность $O \l(N^{3}\r)$ шага выполнения разностной схемы предиктор-корректор до $O (RN\log N)$ без потери точности, где $N$ задает количество используемых уравнений, а $R$ определяет ранг массивов кинетических коэффициентов. Эффективность и точность нового численного метода продемонстрированы для модельных задач агрегационной кинетики.

We consider a model of aggregation processes for the Smoluchowski-type kinetic equations with three-body collisions of particles. We propose a numerical method for the fast solving of Cauchy problems for the corresponding systems of equations. The proposed method allows one to reduce the step complexity $O \l(N^{3}\r)$ of the finite-difference predictor-corrector scheme to $O (RN\log N)$ without loss of accuracy. Here the parameter $N$ specifies the number of considered equations and $R$ is the rank of kinetic coefficient arrays. The efficiency and accuracy of the proposed numerical method are demonstrated for model problems of aggregation kinetics.
A study of implementation methods for the Sobel filter on reconfigurable computing systems
Authors: Таратута Е.Е.
Published: August 2021

Основной мотивацией для данной статьи послужила растущая популярность реконфигурируемых ПЛИС (программируемых логических интегральных схем) в области высокопроизводительных вычислений, а также необходимость исследовать особенности написания эффективных программ с использованием инструмента Altera SDK for OpenCL, позволяющего писать приложения для ПЛИС с помощью языка программирования Си++ и стандарта OpenCL. В статье рассмотрены особенности программной модели OpenCL и представлено исследование производительности и особенностей различных реализаций фильтра Собеля с использованием указанного инструмента.

The main motivation is the growing popularity of reconfigurable FPGAs in the field of high-performance computing as well as the need to study the features of writing efficient software using the Altera SDK for OpenCL tool, which allows one to implement applications for FPGA using the C++ programming language and the OpenCL standard. The paper discusses the features of the OpenCL software model and presents a study of the performance and features of various Sobel filter implementations using the mentioned tool.
The use of MPI and OpenMP technologies for subsequence similarity search in very long time series on a computer cluster system with nodes based on the Intel Xeon Phi Knights Landing many-core processor
Authors: Краева Я.А. , Цымблер М.Л.
Published: August 2021

В настоящее время поиск похожих подпоследовательностей требуется в широком спектре приложений интеллектуального анализа временных рядов: моделирование климата, финансовые прогнозы, медицинские исследования и др. В большинстве указанных приложений при поиске используется мера схожести Dynamic Time Warping (DTW), поскольку на сегодняшний день научное сообщество признает меру DTW одной из лучших для большинства предметных областей. Мера DTW имеет квадратичную вычислительную сложность относительно длины искомой подпоследовательности, в силу чего разработан ряд параллельных алгоритмов ее вычисления на устройствах FPGA и многоядерных ускорителях с архитектурами GPU и Intel MIC. В настоящей статье предлагается новый параллельный алгоритм для поиска похожих подпоследовательностей в сверхбольших временных рядах на кластерных системах с узлами на базе многоядерных процессоров Intel Xeon Phi поколения Knights Landing (KNL). Вычисления распараллеливаются на двух уровнях: на уровне всех узлов кластера - с помощью технологии MPI и в рамках одного узла кластера - с помощью технологии OpenMP. Алгоритм предполагает использование дополнительных структур данных и избыточных вычислений, позволяющих эффективно задействовать возможности векторизации вычислений на процессорных системах Phi KNL. Эксперименты, проведенные на синтетических и реальных наборах данных, показали хорошую масштабируемость алгоритма.

Nowadays, the subsequence similarity search is required in a wide range of time series mining applications: climate modeling, financial forecasts, medical research, etc. In most of these applications, the Dynamic Time Warping (DTW) similarity measure is used, since DTW is empirically confirmed as one of the best similarity measures for the majority of subject domains. Since the DTW measure has a quadratic computational complexity with respect to the length of query subsequence, a number of parallel algorithms for various many-core architectures are developed, namely FPGA, GPU, and Intel MIC. In this paper we propose a new parallel algorithm for subsequence similarity search in very large time series on computer cluster systems with nodes based on Intel Xeon Phi Knights Landing (KNL) many-core processors. Computations are parallelized on two levels as follows: by MPI at the level of all cluster nodes and by OpenMP within a single cluster node. The algorithm involves additional data structures and redundant computations, which make it possible to efficiently use the capabilities of vector computations on Phi KNL. Experimental evaluation of the algorithm on real-world and synthetic datasets shows that the proposed algorithm is highly scalable.
Target optimization of a supercomputer task flow
Authors: Леоненков С.Н.
Published: August 2021

Настоящая статья является результатом исследования потока задач суперкомпьютеров "Ломоносов" и "Ломоносов-2". Предложен подход к оценке эффективности функционирования суперкомпьютерной системы, основанный на ее базовых характеристиках. Введена новая функция потери качества планирования суперкомпьютера. Подход позволяет сравнивать разные суперкомпьютерные системы исходя из целей использования, которые стоят перед системными администраторами вычислительных центров. Описан опыт применения целевой оптимизации процессов планирования, основанной на предложенном подходе, для суперкомпьютеров "Ломоносов" и "Ломоносов-2".

This paper is a result of studying the task flows observed on the Lomonosov and Lomonosov-2 supercomputers. A new approach to evaluating the performance of a supercomputer system based on its basic performance characteristics is proposed. A supercomputer's scheduling efficiency function is introduced for Lomonosov, Lomonosov-2 and other systems. The approach allows the system administrators to compare various supercomputer systems based on their usage aims. This paper describes the Moscow State University experience of applying the proposed approach to the optimization of Lomonosov and Lomonosov-2 scheduling resources.
Spectral analysis of discrete signals with high frequency resolution
Authors: Осипов О.В.
Published: August 2021

Представлены алгоритмы прямого и обратного быстрого преобразований Фурье (БПФ), позволяющие обрабатывать дискретные сигналы с высоким частотным разрешением, в том числе с небольшим количеством отсчетов получать амплитудночастотные характеристики с длиной набора частот, большей, чем длина исходного дискретного сигнала. Временная сложность разработанных алгоритмов для прямого и обратного БПФ равна
O(N R log2 N), где R частотное разрешение спектральной характеристики (отношение длины набора частот к длине N набора отсчетов сигнала). Разработанные методы позволят увеличить разрешающую способность отечественных систем цифровой обработки сигналов и могут быть реализованы в электронике и программном обеспечении для спектрального анализа.

Algorithms of direct and inverse fast Fourier transforms are discussed. These algorithms allow one to process discrete signals with high frequency resolution, including with a small number of frequency samples, and to receive the frequency responses with a set length of frequencies greater than the length of the original discrete signal. The time complexity of the developed algorithms for the direct and inverse FFT is O(N R log2 N), where R is the frequency resolution of the spectral characteristic (the ratio of the length of a set of frequencies to the length N of a set of signal samples). The developed methods allow one to increase the resolution of systems of digital signal processing and can be implemented in electronic devices and in software for spectral analysis.