bluuebunny/crossref_metadata_2025 huggingface dataset:
Causal Shannon–Fisher Characterization of Motor/Imagery Movements in EEG
Authors: Baravalle Román , Rosso Osvaldo A. , Montani Fernando
Published: September 2018

The electroencephalogram (EEG) is an electrophysiological monitoring method that allows us to glimpse the electrical activity of the brain. Neural oscillations patterns are perhaps the best salient feature of EEG as they are rhythmic activities of the brain that can be generated by interactions across neurons. Large-scale oscillations can be measured by EEG as the different oscillation patterns reflected within the different frequency bands, and can provide us with new insights into brain functions. In order to understand how information about the rhythmic activity of the brain during visuomotor/imagined cognitive tasks is encoded in the brain we precisely quantify the different features of the oscillatory patterns considering the Shannon–Fisher plane H × F . This allows us to distinguish the dynamics of rhythmic activities of the brain showing that the Beta band facilitate information transmission during visuomotor/imagined tasks.
Emissions from the Road Traffic of West African Cities: Assessment of Vehicle Fleet and Fuel Consumption
Authors: Doumbia Madina , Toure N’Datchoh E. , Silue Siélé , Yoboue Véronique , Diedhiou Arona. , Hauhouot Célestin
Published: September 2018

Traffic source emission inventories for the rapidly growing West African urban cities are necessary for better characterization of local vehicle emissions released into the atmosphere of these cities. This study is based on local field measurements in Yopougon (Abidjan, Côte d’Ivoire) in 2016; a site representative of anthropogenic activities in West African cities. The measurements provided data on vehicle type and age, traveling time, fuel type, and estimated amount of fuel consumption. The data revealed high traffic flow of personal cars on highways, boulevards, and backstreets, whereas high flows of intra-communal sedan taxis were observed on main and secondary roads. In addition, the highest daily fuel consumption value of 56 L·day−1 was recorded for heavy vehicles, while the lowest value of 15 L·day−1 was recorded for personal cars using gasoline. This study is important for the improvement of uncertainties related to the different databases used to estimate emissions either in national or international reports. This work provides useful information for future studies on urban air quality, climate, and health impact assessments in African cities. It may also be useful for policy makers to support implementation of emission reduction policies in West African cities.
Scrutinising the Gap between the Expected and Actual Deployment of Carbon Capture and Storage—A Bibliometric Analysis
Authors: Viebahn Peter , Chappin Emile J. L.
Published: September 2018

For many years, carbon capture and storage (CCS) has been discussed as a technology that may make a significant contribution to achieving major reductions in greenhouse gas emissions. At present, however, only two large-scale power plants capture a total of 2.4 Mt CO2/a. Several reasons are identified for this mismatch between expectations and realised deployment. Applying bibliographic coupling, the research front of CCS, understood to be published peer-reviewed papers, is explored to scrutinise whether the current research is sufficient to meet these problems. The analysis reveals that research is dominated by technical research (69%). Only 31% of papers address non-technical issues, particularly exploring public perception, policy, and regulation, providing a broader view on CCS implementation on the regional or national level, or using assessment frameworks. This shows that the research is advancing and attempting to meet the outlined problems, which are mainly non-technology related. In addition to strengthening this research, the proportion of papers that adopt a holistic approach may be increased in a bid to meet the challenges involved in transforming a complex energy system. It may also be useful to include a broad variety of stakeholders in research so as to provide a more resilient development of CCS deployment strategies.
Severity of Overstory Mortality Influences Conifer Recruitment and Growth in Mountain Pine Beetle-Affected Forests
Authors: Pelz Kristen A. , Rhoades Charles C. , Hubbard Robert M. , Smith Frederick W.
Published: September 2018

The severity of lodgepole pine mortality from mountain pine beetle outbreaks varies with host tree diameter, density, and other structural characteristics, influencing subcanopy conditions and tree regeneration. We measured density and leader growth of shade-intolerant lodgepole pine, shade-tolerant Engelmann spruce, and very shade-tolerant subalpine fir regeneration beneath stands that experienced moderate and high overstory lodgepole pine mortality (average 40% and 85% of total basal area) a decade earlier. Lodgepole comprised >90% of the overstory basal area and mature spruce and fir were present in both mortality levels, though live basal area and disturbance history differed. Post-beetle outbreak recruitment was high in both mortality levels, but there were more lodgepole in high than moderate mortality plots (1140 stems ha−1 vs. 60 stems ha−1) and more subalpine fir in moderate than high mortality plots (4690 stems ha−1 vs. 2870 stems ha−1). Pine advance regeneration, established prior to outbreak, was more dense in high mortality than moderate mortality sites (930 stems ha−1 vs. 310 stems ha−1), but the trend was generally the opposite for the other conifers. Lodgepole recruitment increased and subalpine fir decreased with greater forest floor light availability. All species grew faster in high mortality areas than their counterparts in moderate mortality areas. However, in high mortality areas pine grew faster than the more shade tolerant species, and in moderate mortality areas spruce and fir grew faster than pine. These species-specific responses to the degree of overstory mortality will influence future stand composition and rate of forest recovery after mountain pine beetle outbreaks.
The Concept of Regulating Forest Management in a Region Subject to High Environmental Pressure
Authors: Borecki Tomasz , Łopiński Łukasz , Kędziora Wojciech , Orzechowski Michał , Wójcik Roman , Stępień Edward
Published: September 2018

In modern forestry, the complexity of the planning process is increasing, specifically in the context of the sustainable use of forest resources and its adaptation to climate changes. This article presents the concept of forest use regulation promoting the sustainable forestry development in forest management planning. A method for defining a synthetic criterion of assessing important features of stand structure was proposed, which would enable the classification of stands in terms of needs and the urgency of their transformation (reconstruction) or suitability for longer standing. As a result, such a concept may ensure the preservation of the relative uniformity of logging use and the improvement of age structure as well as an increase of natural values of the forest, regardless of a stand’s age. The concept was tested on a large forest complex (over 0.5 million hectares) subjected to intense environmental pressure (Silesian Region in Poland). We prepared long-term individualistic development forecasts, separately for area and volume. Based on this, we followed the cutting uniformity principle in the analysed time period by calculating a long-term average of cutting allowance. It was determined by averaging the projected usage size in moving window and eventually was adopted as the cutting upper limit in the whole analysed period. The proposed size of cuts in each period resulted from the relation between the average value and the forecast. Three sets of stands of the differentiated urgency of interventions were distinguished: I—well-stocked and stable stands (no need of intervention)—55% of stands area, II – acceptable stands (not urgent intervention needed)—35% and III—poor stands (urgent intervention needed)—10%. This concept joins top-down and bottom-up approach of cutting uniformity that focuses stand’s status instead of its age or dimensions.
1-Kestose, the Smallest Fructooligosaccharide Component, Which Efficiently Stimulates Faecalibacterium prausnitzii as Well as Bifidobacteria in Humans
Authors: Tochio Takumi , Kadota Yoshihiro , Tanaka Toshio , Koga Yasuhiro
Published: September 2018

The concept of prebiotics was established more than 30 years ago. While the prebiotic concept has now expanded thus includes non-carbohydrate substances and diverse categories other than foods, fructooligosaccharides (FOS) have still predominantly been used as pebiotics, because the effects of FOS exclusively act through the enrichment of Bifidobacterium and Lactobacillus spp., which have been classified as beneficial intestinal commensals so far. Now the commercially available FOS products are synthetic mixture of several kinds of FOS components including 1-kestose (GF2), nystose (GF3) and GF4. In our previous studies, superiority of 1-kestose to the longer-chain FOS components such as nystose with regard to bifidogenic activity was clearly demonstrated. Recently, a broader range of beneficial bacteria including butyrate-producing indigenous bacteria have been recognized and expected to be new probiotic strains. Among them, resident Faecalibacterium prausnitzii is a butyrate producer with a significant anti-inflammatory effect thus expected to be useful as a next-generation probiotic. However, this bacterium is extremely oxygen-sensitive thus can be difficult to grow industrially. On the other hand, we have clearly demonstrated a significant prebiotic effect of 1-kestose, which is the smallest component of FOS, on F. prausnitzii in the gut of humans. These findings suggest that 1-kestose has impressive potential as a new prebiotic targeting F. prausnitzii, a next-generation probiotic strain, as well as bifidobacteria.
The Na/K-ATPase Signaling: From Specific Ligands to General Reactive Oxygen Species
Authors: Pratt Rebecca D. , Brickman Cameron R. , Cottrill Cameron L. , Shapiro Joseph I. , Liu Jiang
Published: September 2018

The signaling function of the Na/K-ATPase has been established for 20 years and is widely accepted in the field, with many excellent reports and reviews not cited here. Even though there is debate about the underlying mechanism, the signaling function is unquestioned. This short review looks back at the evolution of Na/K-ATPase signaling, from stimulation by cardiotonic steroids (also known as digitalis-like substances) as specific ligands to stimulation by reactive oxygen species (ROS) in general. The interplay of cardiotonic steroids and ROS in Na/K-ATPase signaling forms a positive-feedback oxidant amplification loop that has been implicated in some pathophysiological conditions.
Gomisin N Alleviates Ethanol-Induced Liver Injury through Ameliorating Lipid Metabolism and Oxidative Stress
Authors: Nagappan Arulkumar , Jung Dae Young , Kim Ji-Hyun , Lee Hoyoung , Jung Myeong Ho
Published: September 2018

Gomisin N (GN), a lignan derived from Schisandra chinensis, has been shown to possess antioxidant, anti-inflammatory, and anticancer properties. In the present study, we investigated the protective effect of GN against ethanol-induced liver injury using in vivo and in vitro experiments. Histopathological examination revealed that GN administration to chronic-binge ethanol exposure mice significantly reduced ethanol-induced hepatic steatosis through reducing lipogenesis gene expression and increasing fatty acid oxidation gene expression, and prevented liver injury by lowering the serum levels of aspartate transaminase and alanine transaminase. Further, it significantly inhibited cytochrome P450 2E1 (CYP2E1) gene expression and enzyme activity, and enhanced antioxidant genes and glutathione level in hepatic tissues, which led to decreased hepatic malondialdehyde levels. It also lowered inflammation gene expression. Finally, GN administration promoted hepatic sirtuin1 (SIRT1)-AMP-activated protein kinase (AMPK) signaling in ethanol-fed mice. Consistent with in vivo data, treatment with GN decreased lipogenesis gene expression and increased fatty acid oxidation gene expression in ethanol-treated HepG2 cells, thereby preventing ethanol-induced triglyceride accumulation. Furthermore, it inhibited reactive oxygen species generation by downregulating CYP2E1 and upregulating antioxidant gene expression, and suppressed inflammatory gene expression. Moreover, GN prevented ethanol-mediated reduction in SIRT1 and phosphorylated AMPK. These findings indicate that GN has therapeutic potential against alcoholic liver disease through inhibiting hepatic steatosis, oxidative stress and inflammation.
PSEN1 p.Thr116Ile Variant in Two Korean Families with Young Onset Alzheimer’s Disease
Authors: Bagyinszky Eva , Lee Hye-Mi , Van Giau Vo , Koh Seong-Beom , Jeong Jee Hyang , An Seong Soo A. , Kim SangYun
Published: September 2018

An in depth study of PSEN1 mutation p.Thr116Ile (c.335C>T) is presented from two Korean families with autosomal dominant inheritance. Clinical manifestation of our patients included memory loss, attention deficits, visuospatial dysfunction, agnosia, aphasia, apraxia, and personality changes, which occurred in their 30s. PSEN1 Thr116Ile was initially discovered in an Italian patient and two French families with early onset Alzheimer’s disease (EOAD) with similar age of onset. To verify the possible pathogenic mechanisms of mutation, in silico predictions and 3D modeling were performed. Structure predictions revealed significant aberrations in first hydrophilic loop (HL-I loop). The hydrophobic isoleucine could alter the loop orientation through increased hydrophobic contacts with the surrounding amino acids. Mutation could destroy a possible hydrogen bond between tyrosine 115 and threonine 116, which may affect the loop conformation. HL-I was confirmed as a conservative region of PSEN1, which may be critical in PSEN1 functions. An additional pathogenic mutation, PSEN1 Thr116Asn, was also found for the same residue, where the patient presented young onset AD (YOND). Other mutations in HL-I loop, such as Tyr115His and Glu120Asp, were described in patients with YOND, supporting the critical role of HL-I loop in PSEN1 activity.
Role of Nitric Oxide in the Cardiovascular and Renal Systems
Authors: Ahmad Ashfaq , Dempsey Sara K. , Daneva Zdravka , Azam Maleeha , Li Ningjun , Li Pin-Lan , Ritter Joseph K.
Published: September 2018

The gasotransmitters are a family of gaseous signaling molecules which are produced endogenously and act at specific receptors to play imperative roles in physiologic and pathophysiologic processes. As a well-known gasotransmitter along with hydrogen sulfide and carbon monoxide, nitric oxide (NO) has earned repute as a potent vasodilator also known as endothelium-derived vasorelaxant factor (EDRF). NO has been studied in greater detail, from its synthesis and mechanism of action to its physiologic, pathologic, and pharmacologic roles in different disease states. Different animal models have been applied to investigate the beneficial effects of NO as an antihypertensive, renoprotective, and antihypertrophic agent. NO and its interaction with different systems like the renin–angiotensin system, sympathetic nervous system, and other gaseous transmitters like hydrogen sulfide are also well studied. However, links that appear to exist between the endocannabinoid (EC) and NO systems remain to be fully explored. Experimental approaches using modulators of its synthesis including substrate, donors, and inhibitors of the synthesis of NO will be useful for establishing the relationship between the NO and EC systems in the cardiovascular and renal systems. Being a potent vasodilator, NO may be unique among therapeutic options for management of hypertension and resulting renal disease and left ventricular hypertrophy. Inclusion of NO modulators in clinical practice may be useful not only as curatives for particular diseases but also for arresting disease prognoses through its interactions with other systems.
The Use of Vascular Endothelial Growth Factor Inhibitors and Complementary Treatment Options in Polypoidal Choroidal Vasculopathy: A Subtype of Neovascular Age-Related Macular Degeneration
Authors: Teo Kelvin Yi Chong , Gillies Mark , Fraser-Bell Samantha
Published: September 2018

Polypoidal choroidal vasculopathy (PCV) is a subtype of neovascular age-related macular degeneration (AMD; nAMD) which occurs more commonly in Asian populations as compared to Caucasians. PCV and nAMD share pathological mechanisms, including pathological expression of vascular endothelial growth factor (VEGF). The advent of anti-vascular endothelial growth factor (VEGF) revolutionized the treatment of nAMD. Despite being a subtype of nAMD, PCV responds less well to VEGF inhibitors; thus, photodynamic therapy (PDT) in combination with anti-VEGF treatment may be considered. This review aims to summarize the current evidence for the treatment of PCV, especially whether VEGF inhibitors should be used alone or in combination with PDT.
Love, Emotion and the Singularity
Authors: Lunceford Brett
Published: September 2018

Proponents of the singularity hypothesis have argued that there will come a point at which machines will overtake us not only in intelligence but that machines will also have emotional capabilities. However, human cognition is not something that takes place only in the brain; one cannot conceive of human cognition without embodiment. This essay considers the emotional nature of cognition by exploring the most human of emotions—romantic love. By examining the idea of love from an evolutionary and a physiological perspective, the author suggests that in order to account for the full range of human cognition, one must also account for the emotional aspects of cognition. The paper concludes that if there is to be a singularity that transcends human cognition, it must be embodied. As such, the singularity could not be completely non-organic; it must take place in the form of a cyborg, wedding the digital to the biological.
Semantic Clustering of Functional Requirements Using Agglomerative Hierarchical Clustering
Authors: Eyal Salman Hamzeh , Hammad Mustafa , Seriai Abdelhak-Djamel , Al-Sbou Ahed
Published: September 2018

Software applications have become a fundamental part in the daily work of modern society as they meet different needs of users in different domains. Such needs are known as software requirements (SRs) which are separated into functional (software services) and non-functional (quality attributes). The first step of every software development project is SR elicitation. This step is a challenge task for developers as they need to understand and analyze SRs manually. For example, the collected functional SRs need to be categorized into different clusters to break-down the project into a set of sub-projects with related SRs and devote each sub-project to a separate development team. However, functional SRs clustering has never been considered in the literature. Therefore, in this paper, we propose an approach to automatically cluster functional requirements based on semantic measure. An empirical evaluation is conducted using four open-access software projects to evaluate our proposal. The experimental results demonstrate that the proposed approach identifies semantic clusters according to well-known used measures in the subject.
Immune-Enhancement and Anti-Inflammatory Activities of Fatty Acids Extracted from Halocynthia aurantium Tunic in RAW264.7 Cells
Authors: Monmai Chaiwat , Go Seok Hyeon , Shin II-Shik , You Sang Guan , Lee Hyungjae , Kang Seok Beom , Park Woo Jung
Published: September 2018

Halocynthia aurantium, an edible ascidian species, has not been studied scientifically, even though tunicates and ascidians are well-known to contain several unique and biologically active materials. The current study investigated the fatty acid profiles of the H. aurantium tunic and its immune-regulatory effects on RAW264.7 macrophage cells. Results of the fatty acid profile analysis showed a difference in ratios, depending on the fatty acids being analysed, including those of saturated fatty acids (SFA), monounsaturated fatty acids (MUFA), and polyunsaturated fatty acids (PUFA). In particular, omega-3 fatty acids, such as eicosatrienoic acid n-3 (ETA n-3), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), were much higher than omega-6 fatty acids. Moreover, the H. aurantium tunic fatty acids, significantly and dose-dependently, increased the NO and prostaglandin E2 (PGE2) production in RAW264.7 cells, for immune-enhancement without cytotoxicity. In addition, these fatty acids regulated the transcription of immune-associated genes, including iNOS, IL-1β, IL-6, COX-2, and TNF-α. These actions were activated and deactivated via Mitogen-activated protein kinase (MAPK)and NF-κB signaling, to regulate the immune responses. Conversely, the H. aurantium tunic fatty acids effectively suppressed the inflammatory cytokine expressions, including iNOS, IL-1β, IL-6, COX-2, and TNF-α, in LPS-stimulated RAW264.7 cells. Productions of COX-2 and PGE2, which are key biomarkers for inflammation, were also significantly reduced. These results elucidated the immune-enhancement and anti-inflammatory mechanisms of the H. aurantium tunic fatty acids in macrophage cells. Moreover, the H. aurantium tunic might be a potential fatty acid source for immune-modulation.
Excited State Structural Evolution of a GFP Single-Site Mutant Tracked by Tunable Femtosecond-Stimulated Raman Spectroscopy
Authors: Tang Longteng , Zhu Liangdong , Taylor Miles A. , Wang Yanli , Remington S. James , Fang Chong
Published: September 2018

Tracking vibrational motions during a photochemical or photophysical process has gained momentum, due to its sensitivity to the progression of reaction and change of environment. In this work, we implemented an advanced ultrafast vibrational technique, femtosecond-stimulated Raman spectroscopy (FSRS), to monitor the excited state structural evolution of an engineered green fluorescent protein (GFP) single-site mutant S205V. This mutation alters the original excited state proton transfer (ESPT) chain. By strategically tuning the Raman pump to different wavelengths (i.e., 801, 539, and 504 nm) to achieve pre-resonance with transient excited state electronic bands, the characteristic Raman modes of the excited protonated (A*) chromophore species and intermediate deprotonated (I*) species can be selectively monitored. The inhomogeneous distribution/population of A* species go through ESPT with a similar ~300 ps time constant, confirming that bridging a water molecule to protein residue T203 in the ESPT chain is the rate-limiting step. Some A* species undergo vibrational cooling through high-frequency motions on the ~190 ps time scale. At early times, a portion of the largely protonated A* species could also undergo vibrational cooling or return to the ground state with a ~80 ps time constant. On the photoproduct side, a ~1330 cm−1 delocalized motion is observed, with dispersive line shapes in both the Stokes and anti-Stokes FSRS with a pre-resonance Raman pump, which indicates strong vibronic coupling, as the mode could facilitate the I* species to reach a relatively stable state (e.g., the main fluorescent state) after conversion from A*. Our findings disentangle the contributions of various vibrational motions active during the ESPT reaction, and offer new structural dynamics insights into the fluorescence mechanisms of engineered GFPs and other analogous autofluorescent proteins.
Imidazolium Chloride: An Efficient Catalyst for Transamidation of Primary Amines
Authors: Tian Qingqiang , Gan Zongjie , Wang Xuetong , Li Dan , Luo Wen , Wang Huajun , Dai Zeshu , Yuan Jianyong
Published: September 2018

A highly efficient and convenient protocol of imidazolium chloride (30 mol %) catalyzed amidation of amines with moderate to excellent yields was reported. The protocol shows broad substrate scope for aromatic, aliphatic, and heterocyclic primary amines.
Chemical Composition and Biological Activities of Essential Oils of Curcuma Species
Authors: Dosoky Noura S. , Setzer William N.
Published: September 2018

Members of the genus Curcuma L. have been used in traditional medicine for centuries for treating gastrointestinal disorders, pain, inflammatory conditions, wounds, and for cancer prevention and antiaging, among others. Many of the biological activities of Curcuma species can be attributed to nonvolatile curcuminoids, but these plants also produce volatile chemicals. Essential oils, in general, have shown numerous beneficial effects for health maintenance and treatment of diseases. Essential oils from Curcuma spp., particularly C. longa, have demonstrated various health-related biological activities and several essential oil companies have recently marketed Curcuma oils. This review summarizes the volatile components of various Curcuma species, the biological activities of Curcuma essential oils, and potential safety concerns of Curcuma essential oils and their components.
Plasma 25-Hydroxy Vitamin D Is Not Associated with Either Cognitive Function or Academic Performance in Adolescents
Authors: Rahman Abdur , Al-Taiar Abdullah , Shaban Lemia , Al-Sabah Reem , Al-Harbi Anwar , Mojiminiyi Olusegun
Published: September 2018

Several observational studies have reported an association between low levels of vitamin D (VD) and poor cognition in adults, but there is a paucity of data on such an association in adolescents. We investigated the association between VD and cognitive function or academic achievement among 1370 adolescents, who were selected from public middle schools in Kuwait, using stratified multistage cluster random sampling with probability proportional to size. Plasma 25-hydroxy VD (25-OH-D) was measured using liquid chromatography-tandem mass spectrometry (LC-MS/MS). An age-adjusted standard score (ASC), calculated from Raven’s Standard Progressive Matrices test, was used to evaluate cognitive function; academic achievements were extracted from the schools’ records. Data on various covariates were collected from the parents through a self-administered questionnaire and from the adolescents using face-to-face interviews. 25-OH-D was weakly correlated positively with ASC (ρ = 0.06; p = 0.04). Univariable linear regression analysis showed an association between 25-OH-D categories and ASC after adjusting for gender, but adjusting for parental education was sufficient to explain this association. Multivariable analysis showed no association between 25-OH-D and ASC after adjusting for potential confounders whether 25-OH-D was fitted as a continuous variable (p = 0.73), a variable that is categorized by acceptable cutoff points (p = 0.48), or categorized into quartiles (p = 0.88). Similarly, 25-OH-D was not associated with academic performance. We conclude that 25-OH-D is associated with neither cognitive function nor academic performance in adolescents.
Breakfast in the United States: Food and Nutrient Intakes in Relation to Diet Quality in National Health and Examination Survey 2011–2014. A Study from the International Breakfast Research Initiative
Authors: Drewnowski Adam , Rehm Colin D. , Vieux Florent
Published: September 2018

The contribution of breakfast to diet quality (DQ) can inform future dietary guidelines. This study examined breakfast nutrition in relation to overall DQ, using dietary data from the first reported day of the National Health and Examination Survey (NHANES) 2011–2014 (n = 14,488). Relative DQ was assessed using the Nutrient Rich Foods Index (NRF9.3) and the USDA Healthy Eating Index 2015 (HEI 2015). The sample was stratified by NRF9.3 tertiles and by age and socioeconomic groups. Four out of 5 NHANES participants had breakfast on the day of the interview. Breakfast provided 19–22% of dietary energy depending on age. Breakfast intakes of complex carbohydrates and total sugars were proportionately higher and intakes of protein and fats were lower relative to breakfast energy intakes. Breakfast provided more that 20% of daily intakes of B vitamins, vitamins A and D, folate, calcium, iron, potassium and magnesium. Eating breakfast was associated with higher NRF9.3 DQ scores. Breakfasts associated with the top tertile of NRF9.3 scores had less added sugars and fats than those associated with the bottom tertile. Such breakfasts had more fruit and juices, more whole grain products, more milk and yogurt and less meat and eggs. Breakfast patterns and food choices that favored fruit, whole grains and dairy were associated with healthiest diets.
Hidden Hunger: Solutions for America’s Aging Populations
Authors: Eggersdorfer Manfred , Akobundu Ucheoma , Bailey Regan L. , Shlisky Julie , Beaudreault Amy R. , Bergeron Gilles , Blancato Robert B. , Blumberg Jeffrey B. , Bourassa Megan W. , Gomes Filomena , Jensen Gordon , Johnson Mary Ann , Mackay Douglas , Marshall Keri , Meydani Simin Nikbin , Tucker Katherine L.
Published: September 2018

The global population, including the United States, is experiencing a demographic shift with the proportion of older adults (aged ≥ 65 years) growing faster than any other age group. This demographic group is at higher risk for developing nutrition-related chronic conditions such as heart disease and diabetes as well as infections such as influenza and pneumonia. As a result, an emphasis on nutrition is instrumental for disease risk reduction. Unfortunately, inadequate nutrient status or deficiency, often termed hidden hunger, disproportionately affects older adults because of systematic healthcare, environmental, and biological challenges. This report summarizes the unique nutrition challenges facing the aging population and identifies strategies, interventions, and policies to address hidden hunger among the older adults, discussed at the scientific symposium “Hidden Hunger: Solutions for America’s Aging Population”, on March 23, 2018.
Levels of Growth Factors and IgA in the Colostrum of Women from Burundi and Italy
Authors: Munblit Daniel , Abrol Priya , Sheth Shreya , Chow Li , Khaleva Ekaterina , Asmanov Alan , Lauriola Silvana , Padovani Ezio , Comberiati Pasquale , Boner Attilio , Warner John , Boyle Robert , Peroni Diego
Published: September 2018

Colostrum is produced in the first days postpartum. It is a known source of immune mediators for a newborn within the first week of life. Although it is still unclear if colostrum composition varies between populations, recent data suggest differences. Hepatocyte growth factor (HGF); transforming growth factor-β (TGF-β) 1, 2, and 3; and immunoglobulin A (IgA) are key immunological components of colostrum that stimulate neonatal gastrointestinal and immune system development. We aimed to investigate the differences in the concentration between immune markers in the colostrum of mothers living in Burundi and Italy, and to identify the factors associated with differences. In this cross-sectional birth cohort study, a total of 99 colostrum samples from Burundian (n = 23) and Italian (n = 76) women were collected at 0 to 6 days postpartum. A clinical chemistry analyser was used for IgA quantification and electro-chemiluminescence, for HGF and TGFβ1-3 assessment. A univariate analysis and multivariate linear regression model were used for statistical testing. The concentrations of TGF-β2 (p = 0.01) and IgA (p < 0.01) were significantly higher in the colostrum from the women residing in Burundi than in Italy, both in a univariate analysis and upon the adjustment for confounding factors. A similar trend is seen for HGF, reaching statistical significance upon a multivariate analysis. We found a moderate to strong positive correlation between the TGF-β isoforms and IgA concentration in both countries (p < 0.01), with stronger concentration in the colostrum from Burundi. The results of this study are in support of previous data, suggesting that concentration of the immune active molecules is higher in the human milk of women residing in developing countries. However, with a small sample size, caution must be applied, as the findings require further confirmation. Future work should also be focused on other factors (e.g., lipid and microbial composition), as well as the investigation into colostrum and between populations comparison, adjusting for potential confounders.
Production, Absorption, and Blood Flow Dynamics of Short-Chain Fatty Acids Produced by Fermentation in Piglet Hindgut during the Suckling–Weaning Period
Authors: Nakatani Masako , Inoue Ryo , Tomonaga Shozo , Fukuta Kikuto , Tsukahara Takamitsu
Published: September 2018

Luminal short-chain fatty acids (SCFA) are rapidly absorbed from the intestine and subsequently utilized by the host as substrate for metabolic energy production. In pigs, the energy contribution of SCFA is thought to be 30–76%. However, since absorption and blood flow dynamics of SCFA in pigs, particularly during the suckling–weaning period, remain unclear, we aimed to elucidate these phenomena. Thirty-two piglets were used in the present work. Cecal vein blood and digesta, and portal and abdominal vein blood were sampled from suckling (7-, 14-, 21- and 28-day-old) and weaned (weaning at 21 and 28 days of age) piglets. Four piglets from each group were euthanized. SCFA concentrations in blood samples were analyzed by a highly sensitive gas chromatography-mass spectrometry technique. Age at weaning tended to affect SCFA absorption. For example, acetate and propionate concentrations in the cecal vein tended to be higher in piglets weaned at day 21 than at day 28. SCFA concentrations in the abdominal vein tended to differ from those in other veins. Mucosal gene expression analysis suggested that monocarboxylate transporter 1 and occludin were associated in absorption of SCFA from the lumen into the blood of piglets.
Significant Reduction of the Friction and Wear of PMMA Based Composite by Filling with PTFE
Authors: Gu Dapeng , Zhang Longxiao , Chen Suwen , Song Kefeng , Liu Shouyao
Published: September 2018

Polytetrafluoroethylene/Poly(methyl methacrylate) (PTFE/PMMA) composite was prepared by mixing PTFE into PMMA matrix which synthesized by the PMMA powder mixture and methyl methacrylate (MMA) liquid mixture. The effects of the filling mass ratio of PTFE and powder/liquid (P/L) ratio on the friction and wear properties of PTFE/PMMA composites against bearing steel were studied by a ball-on-disk tribometer. Fourier transform infrared (FTIR), field emission scanning electron microscopy (FESEM), and energy dispersive X-ray spectroscopy (EDS) were used to characterize the synthesis of PTFE/PMMA composite. The shore hardness and glass transition temperature (Tg) were obtained respectively by shore hardness tester and differential scanning calorimetry (DSC). The results show that the friction coefficient and wear rate of PMMA based composite, comparing with the unfilled PMMA, can be significantly reduced by filling with PTFE. With the increasing of PTFE filling mass ratio, the wear rate of PTFE/PMMA composite increases. The friction coefficient and wear rate of the unfilled PMMA and PTFE/PMMA composite generally decrease with the P/L ratio increasing. The main wear mechanism of the unfilled PMMA is adhesive wear. While the main wear mechanisms of PTFE/PMMA composites are fatigue wear and abrasive wear.
Effect of Extrusion Temperature on the Physico-Mechanical Properties of Unidirectional Wood Fiber-Reinforced Polylactic Acid Composite (WFRPC) Components Using Fused Deposition Modeling
Authors: Yang Teng-Chun
Published: September 2018

Wood fiber-reinforced polylactic acid (PLA) composites (WFRPCs) were used as a filament to manufacture the unidirectional WFRPC components by means of fused deposition modeling (FDM). The physico-mechanical properties of the WFRPC components printed at different extrusion temperatures (200, 210, 220, and 230 °C) were determined. The results revealed that most of the physical properties (moisture content, surface roughness, water absorption rate, and thickness swelling rate) of the printed WFRPC component were not significantly influenced by extrusion temperature, while its density and color difference increased as the extrusion temperature increased. Additionally, the tensile and flexural properties of the FDM-printed WFRPC component decreased when the extrusion temperature was more than 200 °C, whereas the compressive strength and internal bond strength increased by 15.1% and 24.3%, respectively, when the extrusion temperature was increased from 200 to 230 °C. Furthermore, scanning electronic microscopy (SEM) demonstrated that the fracture surface of the tensile component printed at a higher extrusion temperature exhibited a better compatibility at fiber/PLA interfaces and good adhesion between the extruded filament segments. These results indicate that the FDM printing process using different extrusion temperatures has a substantial impact on the surface color, density, and mechanical properties of the printed WFRPC component.
Soft Gelatin Films Modified with Cellulose Acetate Phthalate Pseudolatex Dispersion—Structure and Permeability
Authors: Maciejewski Bartosz , Ström Anna , Larsson Anette , Sznitowska Małgorzata
Published: September 2018

Gastroresistant material, based on gelatin and intended to form capsule shells, was characterized. The films were obtained by mixing a gelatin solution with cellulose acetate phthalate (CAP) pseudolatex at an elevated temperature. Microscopic and spectroscopic analyses of the films—intact or subjected to the acidic treatment—were performed, along with a permeability study of tritium-labeled water. A uniform porous structure formed by CAP within the gelatin gel was observed. The results demonstrated that no interaction of a chemical nature occurred between the components. Additionally, the performed permeability and solubility studies proved that the diffusion of water through the membranes at an acidic pH can be noticeably reduced by adding carrageenan as a secondary gelling/thickening agent.
Model Development and Validation of Fluid Bed Wet Granulation with Dry Binder Addition Using a Population Balance Model Methodology
Authors: Muddu Shashank Venkat , Tamrakar Ashutosh , Pandey Preetanshu , Ramachandran Rohit
Published: September 2018

An experimental study in industry was previously carried out on a batch fluid bed granulation system by varying the inlet fluidizing air temperature, binder liquid spray atomization pressure, the binder liquid spray rate and the disintegrant composition in the formulation. A population balance model framework integrated with heat transfer and moisture balance due to liquid addition and evaporation was developed to simulate the fluid bed granulation system. The model predictions were compared with the industry data, namely, the particle size distributions (PSDs) and geometric mean diameters (GMDs) at various time-points in the granulation process. The model also predicted the trends for binder particle dissolution in the wetting liquid and the temperatures of the bed particles in the fluid bed granulator. Lastly, various process parameters were varied and extended beyond the region studied in the aforementioned experimental study to identify optimal regimes for granulation.
Pausanian Classification or Socratic Participation: Theologizing the Plurality of Erotic Praxis in Plato’s Symposium
Authors: Krinks Philip
Published: September 2018

Read theologically, Plato’s Symposium is an exercise in doxology: how Eros is to be praised. Pausanias observes that, since Eros is not one, a unitary praise will be inadequate. Proposing a focus on praxis, he classifies erotic praxes, and praises one, in a synthesis of contemporary convention, sophistic rationality, social responsibility and polytheistic fidelity. Against this Socrates praises erotic praxis as one of a plurality of desires mediating between mortals and an otherwise transcendent good. Desire which is specifically erotic involves a praxis of (pro)creation through attention to beauty. In this praxis mortals participate in immortality and the divine. Pausanias’ praise is seriously offered. However, lacking a participatory element, it delivers an underwhelming doxology, making Eros at best an instrument of a sophistically constructed virtue ethic to which his polytheism is ambiguously connected. It is the philosophical theology of Socrates, which, praising Eros as a mediator enabling participation in the divine realm, and offering itself as an analogous form of mediation, is able to be consummated liturgically.
Monitoring and Analysis of Surface Deformation in Mining Area Based on InSAR and GRACE
Authors: Zheng Meinan , Deng Kazhong , Fan Hongdong , Du Sen
Published: September 2018

To determine the relationship between underground mining, groundwater storage change, and surface deformation, we first used two sets of ENVISAT data and one set of Sentinel-1A data to obtain surface deformation in eastern Xuzhou coalfield based on the temporarily coherent point interferometric synthetic aperture radar (TCPInSAR) technique. By comparison with underground mining activities, it indicated that the surface subsidence is mainly related to mine exploitation and residual subsidence in the goaf, while the surface uplift is mainly related to restoration of the groundwater level. The average groundwater storage change in the eastern Xuzhou coalfield from January 2005 to June 2017 was obtained through the Gravity Recovery and Climate Experiment (GRACE) data, and the results indicated that the groundwater storage changed nonlinearly with time. The reliability of the groundwater monitoring results was qualitatively validated by using measured well data from April 2009 to April 2010. Combining with time of mining and mine closing analysis, groundwater storage change within the research area had a strong correlation with drainage activity of underground mining. An analysis was finally conducted on the surface deformation and the groundwater storage change within the corresponding time. The results indicated that the groundwater storage variation in the research area has a great influence on the surface deformation after the mine closed.
Sensitivity of Sentinel-1 Backscatter to Vegetation Dynamics: An Austrian Case Study
Authors: Vreugdenhil Mariette , Wagner Wolfgang , Bauer-Marschallinger Bernhard , Pfeil Isabella , Teubner Irene , Rüdiger Christoph , Strauss Peter
Published: September 2018

Crop monitoring is of great importance for e.g., yield prediction and increasing water use efficiency. The Copernicus Sentinel-1 mission operated by the European Space Agency provides the opportunity to monitor Earth’s surface using radar at high spatial and temporal resolution. Sentinel-1’s Synthetic Aperture Radar provides co- and cross-polarized backscatter, enabling the calculation of microwave indices. In this study, we assess the potential of Sentinel-1 VV and VH backscatter and their ratio VH/VV, the cross ratio (CR), to monitor crop conditions. A quantitative assessment is provided based on in situ reference data of vegetation variables for different crops under varying meteorological conditions. Vegetation Water Content (VWC), biomass, Leaf Area Index (LAI) and height are measured in situ for oilseed-rape, corn and winter cereals at different fields during two growing seasons. To quantify the sensitivity of backscatter and microwave indices to vegetation dynamics, linear and exponential models and machine learning methods have been applied to the Sentinel-1 data and in situ measurements. Using an exponential model, the CR can account for 87% and 63% of the variability in VWC for corn and winter cereals. In oilseed-rape, the coefficient of determination ( R 2 ) is lower ( R 2 = 0.34) due to the large difference in VWC between the two growing seasons and changes in vegetation structure that affect backscatter. Findings from the Random Forest analysis, which uses backscatter, microwave indices and soil moisture as input variables, show that CR is by and large the most important variable to estimate VWC. This study demonstrates, based on a quantitative analysis, the large potential of microwave indices for vegetation monitoring of VWC and phenology.
Source Model and Stress Disturbance of the 2017 Jiuzhaigou Mw 6.5 Earthquake Constrained by InSAR and GPS Measurements
Authors: Hong Shunying , Zhou Xin , Zhang Kui , Meng Guojie , Dong Yanfang , Su Xiaoning , Zhang Lei , Li Shuai , Ding Keliang
Published: September 2018

Seismogenic fault geometry, especially for a blind fault, is usually difficult to derive, based only on the distribution of aftershocks and interference fringes of Interferometric Synthetic Aperture Radar (InSAR). To better constrain the fault geometry of the 2017 Jiuzhaigou Mw 6.5 earthquake, we first carried out a nonlinear inversion for a single fault source using multi-peak particle swarm optimization (MPSO), Monte Carlo (MC), and Markov Chain Monte Carlo (MCMC) algorithms, respectively, with constraints of InSAR data in multiple SAR viewing geometries. The fault geometry models retrieved with different methods were highly consistent and mutually verifiable, showing that a blind faulting with a strike of ~154° and a dip angle of ~77° was responsible for the Jiuzhaigou earthquake. Based on the optimal fault geometry model, the fault slip distribution jointly inverted from the InSAR and Global Positioning System (GPS) data by the steepest descent method (SDM) and the MC method showed that the slip was mainly concentrated at the depth of 1–15 km, and only one slip center appeared at the depth of 5–9 km with a maximum slip of about 1.06 m, some different from previous studies. Taking the shear modulus of μ = 32 GPa, the seismic moment derived from the distributed slip model was about 7.85 × 1018 Nm, equivalent to Mw 6.54, which was slightly larger than that from the focal mechanism solutions. The fault spatial geometry and slip distribution could be further validated with the spatial patterns of the immediate aftershocks. Most of the off-fault aftershocks with the magnitude > M2 within one year after the mainshock occurred in the stress positive stress change area, which coincided with the stress triggering theory. The static Coulomb stress, triggered by the mainshock, significantly increased at the Tazang fault (northwest to the epicenter), and at the hidden North Huya fault, and partial segments of the Minjiang fault (west of the epicenter).
Thermal Imaging for the Archaeological Investigation of Historic Buildings
Authors: Brooke Christopher
Published: September 2018

A significant problem in understanding the archaeology of standing buildings relates to the proscription to uncover features and structures within plastered and rendered walls due to the susceptibility and historic importance of such structures. Infrared thermography offers a method of visualization that is nondestructive and capable of revealing various types of archaeological anomaly that has been demonstrated on a small scale in the past. A passive infrared thermal camera is used to examine several historic buildings that are known or suspected to contain hidden archaeological information; the technique is also presented on complex, exposed historic building fabric. The results confirm that it is possible to detect various types of man-made anomaly and to differentiate building materials. In consequence, the use of passive thermal infrared imaging is shown to be a valuable tool in the examination and recording of historic buildings and structures.