bluuebunny/crossref_metadata_2025 huggingface dataset:
Management of a complete denture in the flat mandibular ridge using a semi-adjustable articulator along with an effective suction method
Authors: Ari Muhammad Dimas Aditya , Laksono Harry , Laksono Valerian , Sanjaya Real Akbar Aucky , Pramesti Tasya Regita , Sitalaksmi Ratri Maya
Published: September 2022

Background: Complete dentures can improve the quality of life of edentulous patients. The selection of a suitable articulator and an impression technique is important to construct a stable and retentive complete denture with good occlusion. The use of a semiadjustable articulator ensures that the dentures can be constructed such that their movement closely resembles the patient’s physiological movements. The effective suction method can ensure the development of the border seal according to the patient’s anatomical condition. The use of a semi-adjustable articulator along with an effective suction method is expected to provide good results in the construction of a complete denture. Purpose: This report aimed to describe the management of individual complete dentures in the flat mandibular ridge using a semi-adjustable articulator along with an effective suction method. Case: A 69-year-old female patient came with a chief complaint of her old dentures being unusable and wanted new dentures made. The patient’s general condition was good, and the last extraction was done three months prior to the patient’s arrival. The mandibular posterior alveolar ridge showed dextral tapering and sinistral flatness. Case Management: A complete denture with an acrylic base was fabricated using a semi-adjustable articulator along with an effective suction method. Conclusion: Flat ridge case management using a semi-adjustable articulator with an effective suction method can improve complete denture retention and stability.
Changes in the Focus of North Korea’s ‘oral literature’ research and 『Oral Literature of Joseon』 by Kim Kwang-jo
Authors:   The Research Of The Korean Classic, Kim Si-yeon
Published: September 2022

This article aims to trace the changes in the focus of “oral literature” research in the flow of North Korean folklore and literature, and reviews Kim Kwang-jo’s 『Oral Literatures of Joseon』(2015) as a work that shows significant changes since the 2000s. North Korea’s research on oral literature seems to have not been in full swing in the 1950s and 1960s under the background that “Joseon folklore” field was established mainly from historical and archaeological perspectives. Since then, as the distinction between the areas of “Joseon folklore” and “Joseon literature” became clear, the discussion of oral literature was transferred from folklore to literature and was mainly dealt with at the literary level until the 2000s.
However, since the 2000s, especially in the 2010s, the theoretical review of oral literature has not been revealed, but only popular publications that re-write the work are found, but there is a tendency to discuss oral literature such as tales and legends as research in the folkloric field. Among them, Kim Kwang-jo’s 『Oral Literatures of Joseon』 is a new proposal by Kim Kwang-jo, a folkloric researcher, to reconsider the perspective and area of research in oral literature, showing a new trend in oral literature. As Joseon literature, it suggests the need to study the history and works of folktales in an independent way, away from the boundaries of oral literature studies.
This trend shows that research on oral literature in North Korea has been called throughout the era, projecting the premise and orientation of various academic fields. Through this, it will be necessary to comprehensively review the changes in the focus and target of the study between the 1950s-60s and the late 2000s.
Effect and meaning of knowledge application of classical novel in the story-telling of 『The Red Sleeve』
Authors:   The Research Of The Korean Classic, Kim Mun-hee
Published: September 2022

The purpose of this study is to discuss the aspects of knowledge application of classical novel and its effect and meaning in 『The Red Sleeve』. 『The Red Sleeve』 is a representative work of cross-media story telling which is adapted for webtoon and drama after it is created as a novel. The story-telling in 『The Red Sleeve』 commonly uses a enjoyment formula of classical novel through Jeon-gi-soo(傳奇叟). It also actively uses joint transcription by court lady, reading aspects of classical novel and way of classical novel circulation through Se-chaek-jeom(貰冊店). It reveals introduction, assessment and awareness about classical novel as well.
Three effects and meanings are revealed by using introduction, assessment and awareness about classical novel which are realized by the way of enjoyment, production and reading aspect and circulation method of classical novel. In terms of character composition, it reveals the effect of creating intellectual mentality and independent personality of heroin. It is common effects in novel, webtoon and drama. It reveals the effects of building and resolving tension and creating interest by making laughter in respect of framework of events. It is a effect which is created while being converted to drama and webtoon. In terms of appreciation from reader and viewer, it reveals the effect that makes the reader and viewer cultivate knowledge and refinement about classics and traditional culture.
In order to help create successful contents like 『The Red Sleeve』 accurate and easily accessible material about classical novel should be provided. It can be a duty of classical novel researcher to provide relevant material about classical novel which is easily accessible to writer, contents creator and the public.
The Literary Imagery and Meaning of Nohgu-eop in the oral narrative
Authors:   The Research Of The Korean Classic, Kim Kuk-hee
Published: September 2022

In this study, the perception and meaning of Nohgu, who appears as a helper in the relationship of the main character, was analyzed using the folktale “A short-lived man gets a wife and lives well” and “an ousted daughter-in-law and a charcoal-grilling bachelor” as texts. In the tale Nohgu arranges an undesirable relationship between men and women to help the main character overcome his fate. Nohgu in the tale “A short-lived man gets a wife and lives well” is in a position to arrange a meeting with the daughter of the Jeongseung family so that the protagonist in danger of short-lived life can survive, and in the tale “an ousted daughter-in-law and a charcoal-grilling bachelor” is in a position to mediate the relationship between the expelled baekjeong daughter-in- law and a bachelor who sells charcoal. The hardships faced by the main characters in the narrative can be divided into the results of natural fate and social contradiction. When helping to overcome the former, Nohgu is recognized as a divine being, but when helping to overcome the latter, Nohgu is recognized as a realistic and reflective person.
Those who carried out Nohgu-eop in the late Joseon Dynasty were severely punished by torture hitting shins and exile to the island. From the perspective of the ruling class, strong regulation would have been needed because the Nohgu-eop was ostensibly contrary to the ethics and threatened the hierarchical order of status. However, in the story, Nohgu is a neighbor without a means of living, and is a divine being related to the faith of Grandmother. The inappropriate relationship between men and women which she arranged, was considered an interest in a class deviation. On the other hand, for the socially disadvantaged storytellers, Nohgu is not subject to punishment, but it brings social and economic empathy, which can be seen through the relationship between Nohgu and the main character in the story. Nevertheless, it is difficult to escape the discourse of control over Nohgu, so the performance of Nohgu is reduced, and the Nohgu-eop is decorated as if it were a coincidence.
Stabilized composition of 26 mg/mL of high molecular weight HA for subcutaneous injection to improve skin quality
Authors: Gavard Molliard Samuel , Bon Bétemps Jérémie , Hadjab Basste , Ghazal Anas , Badi Mhd , Cerrano Marco
Published: September 2022

Aim: Skin firmness is one of the key parameters to define skin quality and facial aging. Among the minimally invasive anti-aging strategies, hyaluronic acid (HA) injection is widely accepted to improve skin quality. While most of the available HA injectables are designed and intended for intradermal injection, a novel HA/sorbitol composition containing 2.6% high molecular weight hyaluronic acid stabilized by sorbitol was recently developed to be specifically injected into the adipose tissue to improve the quality of all skin layers, especially the skin firmness. Methods: The HA/sorbitol composition was investigated versus product comparators in terms of biophysical properties, tolerance in subcutaneous tissue with in vivo implantation study, and skin firmness assessment on human skin explants. Results: The HA/sorbitol composition was characterized by unique and differentiated biophysical properties, proper distribution and high tolerance of the gel composition into the adipose tissue, and the ability to efficiently improve skin firmness. Conclusion: The HA/sorbitol composition represents a new attractive solution to treat facial skin aging with an injection strategy specifically targeting the adipose tissue instead of the dermis, to improve the quality of the skin.
CÁLCULO DE APROXIMACIÓN A LA RAÍZ CUADRADA CON EL MÉTODO BABILÓNICO USANDO TRES PARADIGMAS DE PROGRAMACIÓN
Authors:   Universidad Tecnológica de Pereira, TREJOS BURITICÁ OMAR IVÁN , MUÑOZ GUERRERO LUIS EDUARDO
Published: September 2022

In this article an algorithmic solution to approximate the square root of a given number, based on the method used by the Babylonians, and using modern computational resources it arises. To implement this algorithmic solution, it has come to functional programming through the Scheme language environment DrRacket version 6.1, to imperative programming in C ++ environment DevC++ version 4.9.9.2 and object-oriented programming in Eclipse Java EE IDE Java environment for Web Developers Version: Moon Service Release 2 (4.4.2). The methodology is part of the quantitative scientific research and technological instrumental order. The algorithm presented and the methodology have been shared with students of Systems and Computer Engineering of the Technological University of Pereira. The results have been significantly favorable quantitatively since it has been able to establish a link between theory and practice as well as in technology as it has helped promote programming among students the idea that when the logic is clear, the paradigm programming language and automatically become clear. With this research experience it is possible to implement solutions to old traditional math problems without losing its northern and efficiency and effectiveness and to find differences and similarities between different programming paradigms.
DISEÑO, CONSTRUCCIÓN Y EVALUACIÓN DE UN GENERADOR DE HIDRÓGENO ADAPTADO A UN MOTOR DE DOS (2) TIEMPOS EN UNA BICICLETA EN LA CIUDAD DE BOGOTÁ
Authors:   Corporación Universitaria Republicana, RODRÍGUEZ RAMÍREZ YIMI LEANDRO , SANDOVAL SUÁREZ SONIA ALEXANDRA , SANTOS MORENO DAVID SEBASTIÁN
Published: September 2022

This article shows the second phase of development of the proposal for the design, construction, and evaluation of a hydrogen generator for bicycles that will be incorporated into a two (2) stroke engine as a mobility alternative in the city of Bogotá. Phase 1 consists of the market analysis that was presented and published in the previous edition of this journal. The objective of this work is part of the use of H2 to contribute to the development of solutions that mitigate the environmental impact.
Modified Transhumeral Amputation
Authors: Stanovski Alexandra , Raviv Dror , Azraq Yusef , Diment Judith , Olshinka Noam , Or Omer
Published: September 2022

Case:

A 7-year-old boy presented with osteosarcoma of the ulna that required a transhumeral amputation. The patient completed neoadjuvant chemotherapy before surgery. To prevent bone overgrowth and improved prosthetic fitting, a modified amputation was performed with acute shortening and distal epiphysis preservation.

Conclusion:

In this modified amputation, bone overgrowth was not seen and repeated surgeries for stump shaping were prevented. The modified technique enabled length for the prosthetic elbow and a wide stump for better fitting. In cases of transhumeral amputation in children, the modified technique should be considered.
Revision Reverse Total Shoulder Arthroplasty With Pectoralis Major Transfer for Anterior Deltoid Deficiency
Authors: Wheelwright John C. , Featherall Joseph , Kazmers Nikolas H. , Tashjian Robert Z. , Chalmers Peter N.
Published: September 2022

Case:

A 70-year-old male patient presented with anterior deltoid weakness from Parsonage-Turner neuropathy status post failed nerve transfer and a failed total shoulder arthroplasty with pseudoparalysis. The patient underwent revision to a reverse total shoulder arthroplasty with concomitant pectoralis major transfer to substitute for the anterior deltoid. An excellent functional result was attained as early as 6 weeks after surgery.

Conclusion:

Pectoralis major transfer can be an effective treatment option for isolated anterior deltoid insufficiency, even in the setting of a reverse total shoulder arthroplasty.
Irreducible Traumatic Fracture-Dislocation of the Hip with Impalement onto the Ischial Spine
Authors: Large Thomas M.
Published: September 2022

Case:

A 45-year-old man appeared to have a central (protrusio) hip dislocation but actually had a transverse posterior wall acetabulum fracture with irreducible posterior dislocation due to impalement of the femoral head on the ischial spine. He underwent urgent open reduction on presentation and subsequent internal fixation in a staged manner. He developed avascular necrosis at 18 months postoperatively.

Conclusion:

The nondisplaced ilioischial and iliopectineal acetabular radiographic lines were alerts that the dislocation was actually posterior. This led to further imaging before any closed reduction attempts because standard reduction maneuvers would have placed the patient at high risk for iatrogenic femoral head or neck fracture.
Fungal Osteomyelitis due to Phaeoacremonium venezuelense
Authors: Rodriguez-Materon Solangel , Trynz Samantha , SanGiovanni Thomas P.
Published: September 2022

Case:

A 56-year-old immunosuppressed man presented with pain and swelling in the medial and anterior right foot with accompanied numbness in the second and third toes 1 month after a puncture wound by a Sylvester palm tree thorn. An intraoperative culture/biopsy returned positive for septic arthritis of the naviculocuneiform joint and fungal osteomyelitis of the navicular, medial, and intermediate cuneiforms due to Phaeoacremonium venezuelense.

Conclusion:

Fungal osteomyelitis is extremely rare. Only 5 cases by Phaeoacremonium venezuelense have been reported previously in the literature. To the best of our knowledge, this is the first case of osteomyelitis by this strain.
Entrapment of the Ulnar Nerve and Artery Associated with Closed Distal Radius and Ulna Fracture
Authors: Tsujino Shohei , Seki Yasuhiro , Shirasawa Shinichi
Published: September 2022

Case:

We encountered a case of entrapment of the ulnar nerve and artery associated with displaced distal radius and ulna fracture. After the closed reduction, a patient noted a severe sensory deficit and had claw hand. Intraoperatively, the proximal edge of the fractured radius was positioned in the space between the ulnar artery and the nerve, and the nerve was entrapped. The entrapment was released surgically with a good 1-year outcome.

Conclusion:

In cases of distal radius fracture, there is a possibility of entrapment of the ulnar nerve. When neurological symptoms worsen after the reduction maneuver, early nerve exploration is needed.
Baastrup's Disease as a Rare Cause of Cauda Equina Syndrome
Authors: Egu Chinedu Brian , D'Aquino Daniel , Mcculloch Thomas , Pasku Dritan
Published: September 2022

Case:

“Baastrup's disease” is a relatively common anatomical condition, controversially recognized as a possible cause of back pain but frequently missed by clinicians of different specialties. We present a rare case of Baastrup's disease causing compression to the cauda equina nerves due to the formation of a large pseudotumoral epidural mass. The patient underwent a successful surgical decompression with remarkable improvement in her neurological presentation. The histopathological findings consisted of increased collagen deposition and chondroid metaplasia.

Conclusion:

Clinicians should be aware of possible cauda equina syndrome in rare cases of Baastrup's disease due to pseudotumoral mass compression in the lumbar spine.
Bilateral Osteotomy of Pedicles for En Bloc Resection of a Malignant Tumor of the Posterior Thoracic Spine
Authors: Aibara Noriyuki , Watanabe Kota , Asano Naofumi , Suzuki Satoshi , Takahashi Yohei , Nori Satoshi , Tsuji Osahiko , Nagoshi Narihito , Yagi Mitsuru , Nakamura Masaya , Matsumoto Morio
Published: September 2022

Case:

A 45-year-old woman had a grade II chondrosarcoma (T2N0M0G2) located at the spinous processes and laminas of T3-6 with the tumor extension into the spinal canal at T3-4. To perform en bloc tumor resection, we released or disarticulated bilateral costovertebral ligaments from T3-6 and cut the bilateral pedicles at T3-5 all from posteriorly. Then, we completed en bloc resection without violating the tumor capsule.

Conclusion:

Our novel procedure, bilateral osteotomy of pedicles for en bloc resection successfully allowed for en bloc tumor resection involving the posterior elements with wide surgical margins.
Recursos tangibles y capacidades de integración como determinantes de las capacidades de creación de conocimiento
Authors: Alvarez-Melgarejo Mileidy , Torres-Barreto Martha Liliana
Published: September 2022

Las empresas en el mercado pueden diferir en sus capacidades para transformar y explotar el conocimiento, lo que puede causar un efecto diferencial en las ganancias, instándolas a que exploren en diversas vías para pasar de su base de recursos y capacidades a mejoras reales en su desempeño. Considerando lo anterior, este artículo sugiere que los recursos tangibles y las capacidades de integración del conocimiento son determinantes de la creación de conocimiento. Este camino permite la aparición de nuevas capacidades, ayuda a generar ventajas competitivas y mejora el desempeño económico de las empresas. La investigación incluye datos cuantitativos de 2093 empresas manufactureras colombianas, con los cuales se realizaron múltiples regresiones lineales que permitieron contrastar las hipótesis. Los resultados indican que los recursos tangibles son precursores clave de la creación de conocimiento, lo que destaca la importancia de ambos: los activos y los procesos de gestión humana dentro de las empresas. También se encontró evidencia para respaldar la integración de las capacidades del conocimiento, ya que influyen en la capacidad de las empresas para explotar el mismo conocimiento. Finalmente, se demostró que la capacidad de reconfiguración influye en la creación de conocimiento dentro de las empresas. Los hallazgos respaldan el papel de los líderes organizacionales en la gestión de los procesos de transformación mediante la combinación efectiva de estos recursos y las capacidades para generar nuevos conocimientos y explotarlos para generar ganancias.
TFP5, a Peptide Derived from Cdk5 Activator p35, Protects Pancreatic β-cells from Glucose Toxicity
Authors: Liu Shunyao , Cao Shilu , Luo Hongyan , Zhang Xia , Bao Li , E Jing , Li Bo , Lan Xiaomei , Zhang Guoqing , Bao Xi , Pant Harish , Zheng Yali
Published: September 2022

Type 2 diabetes mellitus (T2DM) is worldwide epidemic, which challenges the health of the public. The pathological hyperactivity of cyclin-dependent kinase 5 (Cdk5) contributes to the pathogenesis of T2DM. P5, a peptide derived from the Cdk5 activator p35, shows excellent performance as a Cdk5 activity inhibitor. However, its inhibitory effect and functional regulation on Cdk5 activity needs to be confirmed. In this study, we conjugated P5 with a fluorescein isothiocyanate (FITC) tag at the N-terminus and a TAT protein transduction domain, an 11-amino acid peptide, at the C-terminus to synthesize TFP5, which was used to inhibits Cdk5 activity. We then evaluated the efficiency of TFP5 in treating T2DM. We demonstrated that TFP5 effectively penetrated pancreatic β-cells, inhibited the pathological hyperactivity of Cdk5, enhanced insulin secretion, and protected penetrated pancreatic β-cells (MIN6 cells) from apoptosis in pancreatic tissues of db/db mice (type II diabetes mice). Furthermore, we found that TFP5 reduced inflammation in pancreatic islets by reducing the expression of inflammatory cytokines, including TGF-β1, TNF-α, and IL-1β. These data indicates that the TFP5 peptide is a promising candidate for T2DM treatment.
A Stochastic Analysis of a Siqr Epidemic Model With Short and Long-term Prophylaxis
Authors: Sekkak Idriss , NASRI BOUCHRA R. , RÉMILLARD BRUNO N. , KONG JUDE DZEVELA , FATINI MOHAMED EL
Published: September 2022

This paper aims to incorporate a high order stochastic perturbation into a SIQR epidemic model with transient prophylaxis and lasting prophylaxis. The existence and uniqueness of the global positive solution is proven and a stochastic condition in order to study the extinction of an infectious disease is established. The existence of a stationary distribution for the stochastic epidemic model is investigated as well. Numerical simulations are conducted to support our theoretical results and an example of application with COVID-19 data from Canada is used to estimate the transmission rate and basic reproduction number while constructing a model fitting the data.
Changes in Great Vedaranyam Swamp, South-east Coast of India over last four decades: study on a crucial site for Migratory Birds of Central and East Asian flyways
Authors: Sathiyaselvam Ponnusamy , Selvaraj Ramesh Kumar , Davande Sham , Sivakumar Swaminathan , Joshi Omkar
Published: September 2022

Great Vedaranyam Swamp (GVS) including Point Calimere Wildlife Sanctuary, a Ramsar site is one of the largest swamps and a very crucial wintering ground for migratory birds that visit India or passing through India for their wintering sites in southern parts of Asia following Central Asian Flyway (CAF) and East Asian Australasian Flyway (EAAF). Both natural and human induced local land-use pattern changes have altered the habitats in Great Vedharanyam Swamp. The present study attempted to understand the temporal changes in the land use and land cover patterns of GVS during last three decades using Geographic Information Systems (GIS). Totally, 16 major landcover classes derived within the area of GVS for five periods of time series satellite images stretched over period of 30 years from 1988, 1999, 2002, 2013 and 2017. The Change detection for major classes of landcover such as Mangroves, Mudflats, Lagoons, Vegetation, Saltpans, Prawn farms etc. was analysed and found overall 30% of the area has changed in the GVS over 30 years`. Two major lagoons namely Seruthalaikkadu and Muthupet lagoons have shrunken in its size over the period.. Over 8,276 ha of natural mudflat areas have changed, i.e. 56% of mudflats area existed in 1988 have been disturbed. The decline in mudflats may cause a huge impact on the waterbird population that winters in GVS. Restoring and maintaining the habitats of the GVS are crucial to reduce the decline in bird populations in GVS.
Role of miRNA-4804-3p in liver injury of chronic hepatitis B through inhibit chemerin/chemokine-like receptor 1 mediated NF-κB signal pathway
Authors: Xing Tongjing , Chen Qiaoling , Li Ali , Wang Qiupeng , Zhang Qian , Xian Jianchun , Wang Xuequan
Published: September 2022

Objective: This study aimed to investigate the role of microRNA (miRNA)-4804-3p in liver injury during chronic hepatitis B virus(HBV) infection through inhibit chemerin/chemokine-like receptor 1(CMKLR1) mediated NF-κB signal pathway.
Methods: miRNA-4804-3p, CMKLR1, extracellular signal regulated kinase (ERK), and nuclear factor kappa B (NF-κB) mRNA expression were detected by qPCR, western blot or immunohistochemistry (IHC). A mouse model of liver injury induced by concanavalin A was established and used for experiments in vivo.
Results: Pearson correlation analysis showed a significantly negative correlation between the expression level of miRNA-4804-3p and CMKLR1 in PBMCs of patients with CHB. The miRNA-4804-3p was significantly negatively correlated with the level of alanine transaminase in patients with CHB. Previous our study have showed that the cytokine secretion of human monocyte lines could be inhibited by miRNA-4804-3p. The level of CMKLR1 gene, phosphorylated ERK (p-ERK) and NF-κB protein in cells transfected with miRNA-4804-3p mimics was significantly decreased compared with that of the negative control group. The levels of IL-2, IL-10, TNF-α and IFN-γ in cell culture supernatant were no significant difference between miRNA-4804-3p mimics+CMKLR1 knocdown group and negative control group. The level of AST after injection with agomiRNA-4804-3p significantly decreased compared with that of pre-injection. The amount of inflammation in liver tissue of mice injected with agomiRNA-4804-3p was significantly lower compared with that of the negative control group, but the amount of fibrosis had no significant alteration.
Conclusions: miRNA-4804-3p may inhibit chemerin/CMKLR1–mediated NF-κB signal pathway and be involved in regulating liver inflammatory injury in CHB. This study might not only provide a new explanation for the pathogenesis of CHB, but also provide new potential molecular markers for the prevention and treatment of CHB.
Tumor microenvironment landscape of epithelial ovarian carcinoma highlights EGR1-driven mechanisms of tumor invasion at single-cell resolution
Authors: Guo Qiuyan , Zhang Yuanfu , Sun Shu , Qi Yue , Dai Yifan , Hao Yangyang , Xin Mengyu , Xu Rongji , Chen Hongyan , Wu Xiaoting , Liu Qian , Kong Congcong , Zhang Guangmei , Wang Peng
Published: September 2022

Identifying underlying molecular mechanisms and biomarkers of epithelial ovarian carcinoma (EOC) proliferation and metastasis remains challenging. Patients of EOC are usually diagnosed at an advanced stage and the availability of invasion-related targets is limited. Herein, we explored the single-cell RNA sequencing (scRNA-seq) dataset of EOC and defined tumor physiological reprograming compared to bulk RNA-seq. The energy metabolism and anti-apoptotic pathway was found as critical contributors to intratumor heterogeneity. Moreover, hypoxia, oxidative phosphorylation (OXPHOS) and glycolysis were positively correlated, which have biologically activity trajectories during epithelial mesenchymal transition (EMT). The HMGH1, EGR1 and RUNX1 were found to be critical inducers of the EMT process in EOC. Experimental validation revealed that suppressed EGR1 decreased the expression of FAS and HSPG2 and associating with EMT progression in EOC. In tumor microenvironment (TME), CAFs were found have significant contribution to tumor immune infiltration and metastasis and accumulation of CAFs was associated with poorer patient survival. In conclusion, physiological features and molecular mechanisms in the TME of EOC were revealed and provided effective targets for the suppression of tumor metastasis.
Prognostic value of morning blood pressure surge in chronic kidney disease
Authors: Ma Zhilan , Wang Yan , Guo Xiaoyan , Ma Lan , Liu Yonghua , Zhou Xiaoling
Published: September 2022

Objective: To investigate the prognostic value of morning blood pressure surge (MBPS) in chronic kidney disease (CKD).
Methods: We investigated the occurrence of a composite endpoints (coronary events, stroke, and heart failure requiring hospitalization, end-stage renal disease, death) in 153 patients (aged ³18 years) with a diagnosis of in CKD. Based on MBPS defined as ≥35 mmHg, patients were divided into a two groups: with MBPS (n = 50) and without MBPS (n = 103). The follow-up period was ³10 months. Baseline demographic, laboratory and follow-up data were collected. The clinical characteristics of the two groups were compared. The relationships between MBPS and endpoint events were analyzed using the Kaplan–Meier method and Cox regression model.
Results: In total, 153 patients ( mean age 41.8 years; 56.86% males) were included in this study. During the follow-up period (mean 4.3 years), 34 endpoint events occurred. After adjustment for the covariates, the risk of Cardiovascular and cerebrovascular events, end-stage renal disease and death remained significantly higher in patients with MBPS [hazard ratio (HR) and 95% confidence interval (CI) 3.124 (1.096–9.130)]. Among the other variables, 24-h systolic blood pressure, and night-time and daytime pulse pressures remained significantly associated with outcome in patients of CKD [1.789 (1.205–2.654), 1.710 (1.200–2.437), and 1.318 (1.096–1.586), respectively].
Conclusion: MBPS was identified as an independent prognostic factor for composite endpoint events (coronary events, stroke, and heart failure requiring hospitalization, end-stage kidney disease) patients with chronic kidney disease patients.
Combined Endoscopic and Microscopic Surgery for Complex Skull Base Tumors: A Single-Center Case Series Study in China
Authors: Ding Yu , Lu XiaoCheng , Pan Pengjie , Sun Liang , Zhu Shixin , Yu ZhengQuan , Wu Jiang , Chen Gang
Published: September 2022

Objective
Surgical treatment of skull base tumors is considered very difficult, especially when the lesion located at the cavernous sinus, petroclival region, and the foramen magnum. The evolution of endoscopic techniques provides effective therapeutic strategies for skull base tumors. In this study, the authors describe a combined microscopic and endoscopic technique to minimize blind spots during microsurgery and investigate its value in resecting complex skull base tumors.
Methods
A retrospective analysis was performed on 51 patients who underwent the combined microscopic-endoscopic surgery to remove skull base tumors from January 2017 to February 2021. The extent of resection and neurological outcome were analyzed to evaluate the feasibility and applicability of the combined microscopic-endoscopic technique in skull base surgery.
Results
Gross total resection was achieved in 45 patients (82%) and near-total resection in 6 (11.8%). Total resection was determined under the microscope in 19 patients, but the residual tumor was detected after endoscopic exploration. New postoperative cranial nerve deficits were reported in 9 patients (17.6%). Of the patients with new-onset cranial nerve deficits, four patients (44.4%) had partial recovery, one (11.1%) patient had no change, and four (44.4%) completely recovered.
Conclusions
The combined microscopic-endoscopic technique effectively integrates microscopes and endoscopes to avoid damaging the surrounding neurovascular structures during surgery. This technique allows for a minimally invasive maximal resection, resulting in a better prognosis for skull base tumors.
Synergistic gel formation in geopolymers of superior mechanical strength synthesized with volcanic ash and slag
Authors: Yanjin Zheng , Rao Feng , Tian Xiang , Lin Shenjian
Published: September 2022

The present work studies gel evolution and microstructure of geopolymers synthesized with volcanic ash (VA) and blast furnace slag (BFS). The synthesis parameters such as BFS proportions on geopolymers formation were investigated. Gel evolution and microstructure of the geopolymers were studied by FTIR, X-ray diffraction (XRD), 29Si NMR spectroscopy, and scanning electron microscopy measurements. Silicate gels (N−S−H) were mainly formed in VA based geopolymers of low compressive strength (14.07 MPa). While with VA and BFS each account for 50%, VA-BFS based geopolymers possessed a compressive strength of 55.6 MPa, as well as the homogeneous C−(A)−S−H and N−A−S−H gels were formed. The C−(A)−S−H and N−A−S−H gels show synergistic effects on mechanical property of the geopolymers. This work provides a clue for the synthesis of geopolymers with superior mechanical properties in areas of architecture.
An Investigation of Prescription Indicators in Outpatient Services among Social Security Organization Facilities in Iran
Authors: Aeenparast Afsoon , Mehrizi Ali Asghar Haeri , Farzadi Faranak
Published: September 2022

Background: Drug is a very important component of health care system and rational use of it is very influential factor in health. The aim of this study was to estimate drug prescription indicators in outpatient services in Social Security Organization’s (SSO) healthcare facilities and also compare them with World Health Organization (WHO) standards.
Methods: This was a cross-sectional study. The data of all prescribed drugs for outpatient visits in 2017 - 2018 were extracted from SSO database. The data was categorized in 4 main sub groups: patient characters, provider characters, service characters and healthcare facility characters.. After data acquisition, data cleaning phase was done and irrelevant data were detected and deleted before final analysis. SPSS and IBM modeler soft wares were used for data analysis. Logistic regression models also was used for detecting inappropriate drug prescription risk factors.
Results: Rapid analysis of extracted data indicated that in 2017 about 150, 981,752 drugs were prescribed for all of outpatients in SSO healthcare facilities in Iran. The aggregation of data indicated that these amount of medicines were prescribed in 45,312,540 physicians’ prescriptions.
The average number of drug items per outpatient prescriptions was estimated 3.33. Rate of prescriptions with injection was 17.5 percent and rate of prescriptions with antibiotic was 37.5 percent.
Logistic Regression Analysis indicated that, patient sex and age, providers’ specialty, type of facility and time of outpatient visit were some indicators that was associated with the risk of inappropriate prescription. (p<0.001).
Conclusions:Rational drug prescription has an important impact on population health and the drug industry economy. In this study all drug prescription criteria were higher than WHO recommended limits. It seems that these pattern will increase the risk of drug interactions and also the affect the cost-effective of drugs. These type of researches provide good evidences for analyzing the present situation and strategies for improving it. It is estimated that providing the monthly and annual report to providers alongside considering some prescription policies for physicians will be helpful in improving the current prescription pattern through the country specially in SSO.
Ethics code: IR.ACECR.IBCRC.REC.1396.2
Study on ambient air quality in Shenyang city during the 13th Five-Year Plan period
Authors: Huang Yu , Chen Xi , Li Hui , Fan Guangjian , Xu Xinyang
Published: September 2022

During the 13th Five-Year Plan period (2016–2020), China has comprehensively strengthened the prevention and control of air pollution. The comprehensive treatment of air pollution has been fully implemented since 2016 and the ambient air quality in China has been improved. In order to study on changes and influencing factors of ambient air quality in the central economic zone of inland provinces in the Northeast China during the 13th Five-Year Plan period, ambient air quality in Heping District of Shenyang from 2016 to 2020 was monitored. The ambient air quality was monitored for seven air pollutants PM10, PM2.5, SO2, NO2, CO, O3 and dust fall at five different locations. The study presents the ambient air quality has significantly improved over the past five years. And the results of grey relational analysis show that secondary industry and green area are the main affecting factors of the ambient air quality in addition to population factors. Appropriately reducing the proportion of secondary industry and increasing the green area are effective measures to improve ambient air quality in the future. These findings would provide a basis for city management to improve the ambient air quality in the Northeast China in the future.
Resting State Functional Connectivity as a Marker of Internalizing Disorder Onset in High-Risk Youth
Authors: Pawlak McKinley , Bray Signe , Kopala-Sibley Daniel C.
Published: September 2022

While research has linked alterations in functional connectivity of resting state brain networks including the default mode (DMN), cognitive control (CCN), and salience networks (SN) to depression and anxiety, little research has examined whether these alterations may be premorbid vulnerabilities. This study examined resting state functional connectivity (RSFC) of the CCN, DMN, and SN as neural markers of risk for developing a first lifetime onset of a depressive or anxiety disorder in adolescents at high familial risk for these disorders. At baseline, 135 participants aged 11–17 completed resting-state functional magnetic resonance imaging (rs-fMRI), measures of internalizing symptoms, and diagnostic interviews to assess history of depressive and anxiety disorders. Diagnostic assessments were completed again at 9- or 18-month follow-up for 112 participants. At baseline, increased CCN connectivity to areas of the visual network, and decreased connectivity between the SN and the precentral gyrus, predicted an increased likelihood of an internalizing disorder onset at follow-up. Altered connectivity between these regions may represent a pre-morbid risk factor for developing a clinically significant onset of an internalizing disorder. Results may have implications for understanding the neural bases of internalizing disorder episodes and for early identification and prevention efforts.
Multiple waves of COVID-19: A pathway model approach
Authors: Vasconcelos Giovani , Pessoa Nathan L. , Silva Natan B. , Macêdo Antônio M. S. , Brum Arthur A. , Ospina Raydonal , Tirnakli Ugur
Published: September 2022

A generalized pathway model, with time dependent parameters, is applied to describe the mortality curves of the COVID-19 disease for several countries that exhibit multiple waves of infections. The pathway approach adopted here is formulated explicitly in time, in the sense that the model’s growth rate for the number of deaths or infections is written as an explicit function of time, rather than in terms of the cumulative quantity itself. This allows for a direct fit of the model to daily data (new deaths or new cases) without the need of any integration. The model is applied to COVID-19 mortality curves for ten selected countries and found to be in very good agreement with the data for all cases considered. From the fitted theoretical curves for a given location, relevant epidemiological information can be extracted, such as the starting and peak dates for each successive wave. It is argued that obtaining reliable estimates for such characteristic points is important for studying the effectiveness of interventions and the possible negative impact of their relaxation, as it allows for a direct comparison of the time of adoption/relaxation of control measures with the peaks and troughs of the epidemic curve.
Simplified procedure for rapidly estimating inelastic responses of numerous high-rise buildings with reinforced concrete shear walls
Authors: Suwansaya Phichaya , Warnitchai Pennung
Published: September 2022

Nonlinear response history analysis (NLRHA) is considered the most accurate procedure for evaluating the seismic performance of high-rise buildings. However, it requires considerable expertise and a significant amount of analysis time, making it inappropriate for evaluating numerous high-rise buildings; for example, estimating the seismic losses of a city for an earthquake scenario. To overcome this limitation, a simplified procedure developed based on the uncoupled modal response history analysis (UMRHA) and coupled shear-flexural cantilever beam model (CSFCBM) is proposed. The underlying assumption is that the UMRHA procedure can compute the nonlinear seismic responses mode-by-mode, where each vibration mode is assumed to behave as a single-degree-of-freedom system. The nonlinear seismic responses are approximately represented by the sum of the modal responses of a few vibration modes. However, UMRHA requires knowledge of the modal properties and modal hysteretic behaviors. Therefore, the CSFCBM is introduced here to estimate the required modal properties and modal hysteretic behaviors. The inelastic seismic demands of the building can be determined using the UMRHA procedure with the computed modal properties obtained by CSFCBM. The accuracy of this proposed procedure is verified considering four high-rise buildings of 19, 30, 34, and 45 stories with reinforced concrete shear walls. The inelastic demands computed by the NLRHA procedure are used as a benchmark and compared with those of the proposed procedure. The results indicate that the proposed procedure provides reasonably accurate demand estimations for all case study buildings with significantly less analysis time than that required by NLRHA.
Impact of the COVID-19 pandemic and multiplex polymerase chain reaction test on outpatient antibiotic prescriptions for pediatric respiratory infection
Authors: Kitagawa Daisuke , Kitano Taito , Furumori Madoka , Suzuki Soma , Shintani Yui , Nishikawa Hiroki , Suzuki Rika , Yamamoto Naohiro , Onaka Masayuki , Nishiyama Atsuko , Kasamatsu Takehito , Shiraishi Naoyuki , Suzuki Yuki , Nakano Akiyo , Nakano Ryuichi , Yano Hisakazu , Maeda Koichi , Yoshida Sayaka , Nakamura Fumihiko
Published: September 2022

This study aimed to evaluate the impact of the prolonged COVID-19 pandemic on outpatient antibiotic prescriptions for pediatric respiratory infections at an acute care hospital in Japan in order to direct future pediatric outpatient antibiotic stewardship.The impact of the COVID-19 pandemic and FilmArray Respiratory Panel (RP) on outpatient antibiotic prescriptions was assessed from January 2019 to December 2021 using an interrupted time series analysis of children <20 years. The overall antimicrobial prescription rate decreased from 38.7% to 22.4% during the pre-pandemic period. The pandemic (relative risk [RR] level, 0.97 [0.58–1.61]; P = 0.90; RR slope, 1.05 [0.95–1.17] per month; P = 0.31) and FilmArray RP (RR level, 0.90 [0.46–1.75]; P = 0.75; RR slope, 0.95 [0.85–1.06] per month; P = 0.33) had no significant effect on the monthly antibiotic prescription rates. The COVID-19 pandemic was not significantly related to the antibiotic prescription rate, suggesting that it did not impact physicians’ behavior toward antibiotic prescriptions. Replacing rapid antigen tests with the FilmArray RP introduced on December 1, 2020, did not affect the magnitude of the reduction in antibiotic prescription rate for pediatric respiratory infections.
Molecular Classification of Endometrial Cancer of Chinese Population
Authors: Kang Nan , Zhang Xiaobo , Wang Zhiqi , Dai Yibo , Chen Ran , Qu Linlin , Lu Shanshan , Kong Fangzhou , Zhu Changbin , Gai Fei , Su Wenqing , Shen Danhua , Wang Jianliu
Published: September 2022

Background: Endometrial cancer (EC) is one of the most prevalent gynecologic tumors. Current diagnosis and treatment of EC no longer rely solely on traditional histopathological classification. Nevertheless, molecular classification of EC demonstrated clear prognostic value and may guide clinical decision-making.
Methods: In this study, archived formalin-fixed paraffin-embedded (FFPE) tissue from 229 EC patients were employed for further research. Four subtypes [POLEultramutated (POLE mut), MMR-deficient (MMR-D), p53 abnormal (p53abn), and no specific molecular profile (NSMP)] were stratified by next-generation sequencing (NGS) panel (Amoy Diagnostics, Xiamen, China) targeting POLE, TP53, BRCA1, and BRCA2 genes and microsatellite instability (MSI) status. Immunohistochemistry (IHC) was applied to detect the expression of P53, MMR and other related proteins.
Results: Distributions of the EC subtype in 229 patients were 12 (5.24%) of POLE mut, 35 (15.28%) of MMR-D, 36 (15.72%) of p53abn, and 146 (63.76%) of NSMP. Compared to published results of EC subtypes in Caucasian including TCGA, ProMisE as well as TransPORTEC, real-world data on Chinese EC displayed a significantly larger proportion of NSMP/CNL (copy number low). In addition, it was found that BRCA2 appeared to be more prevalent in EC than BRCA1. Further analysis revealed that the overall consistency for NGS-based and IHC-based P53 abnormalities detection and MSI/MMR status assessment were as high as 89.08% and 96.94%, respectively, and about half of truncating mutations can result in detectable (but nonfunctional) p53 protein yielding a normal wild-type staining pattern.
Conclusions: Chinese ECs have unique molecular characteristics. In order to perform accurate molecular typing of Chinese ECs, more molecular indicators that match the characteristics of the Chinese population should be added to the existing classifiers. Further analysis revealed a high consistency between NGS and IHC in P53 detection and MSI evaluation.
Predictive value of early CTSI scores for early organ failure in patients with acute pancreatitis: a 5-year retrospective study from the emergency department of a large tertiary hospital
Authors: He Yang , Ding Ying , Li Jinyue , Zhou DaoYang , Zhan Kun
Published: September 2022

Objective: Acute pancreatitis (AP) is a life-threatening disease frequently encountered in emergency rooms. We need to explore the significance of early CTSI score in patients with acute pancreatitis, especially in the assessment of organ failure.
Methods: A total of 2828 AP patients between October 2013 to March 2019 were included in this study. We collected data such as age, sex, vital signs on admission (heart rate, systolic blood pressure, respiratory rate, GCS score), test data (creatinine, P/F), imaging content (pleural effusion, pancreatic necrosis score, Balthazar grades, CTSI score). We performed a retrospective analysis of the data.
Results: AP patients who develop early organ failure have older age, faster heart rate, higher blood pressure and faster respiratory rate(P<0.001). If a pleural effusion is found on Computed Tomography (CT) examination, the patient may have organ failure. The mean CTSI score of AP patients with organ failure was 4.84, which was higher than that of patients without early organ failure. The area under the ROC curve of CTSI is 0.683, the cut-off is 3.5, the sensitivity is 68.3%, and the specificity is 61.5%.
Conclusions: Vital signs of patients are closely related to organ failure. Early CTSI score is meaningful and has suggestive value for early organ failure. A routine CTSI score for patients with pancreatitis can help emergency physicians assess the condition.