Discovering HIV related information by means of association rules and machine learning
Authors: Araujo Lourdes , Martinez-Romo Juan , Bisbal Otilia , Sanchez-de-Madariaga Ricardo ,   The Cohort of the National AIDS Network (CoRIS), Portilla Joaquín , Portilla Irene , Merino Esperanza , García Gema , Agea Iván , Sánchez-Payá José , Rodríguez Juan Carlos , Giner Livia , Reus Sergio , Boix Vicente , Torrus Diego , Pérez Verónica , Portilla Julia , Gómez Juan Luís , Hernández Jehovana , Lirola Ana López , García Dácil , Díaz-Flores Felicitas , Alonso M. Mar , Pelazas Ricardo , Alemán M. Remedios , Asensi Víctor , Carmenado María Eugenia Rivas , Suarez-Zarracina Tomás , Pulido Federico , Rubio Rafael , Bisbal Otilia , Hernando M. Asunción , Rial David , de Lagarde María , Arce Octavio , Pinto Adriana , Bermejo Laura , Santacreu Mireia , Navarro Roser , Gonzalez Candela , Iribarren Jose Antonio , Aramburu M. José , Camino Xabier , von Wichmann Miguel Ángel , Goenaga Miguel Ángel , Bustinduy M. Jesús , Azkune Harkaitz , Ibarguren Maialen , Kortajarena Xabier , Álvarez-Rodriguez Ignacio , Gil Leire , Martínez Lourdes , Gutiérrez Félix , Robledano Catalina , Masiá Mar , Padilla Sergio , Adsuar Araceli , Pascual Rafael , Fernández Marta , Galiana Antonio , García José Alberto , Barber Xavier , Agullo Vanessa , Abellán Javier Garcia , Pascual Reyes , Telenti Guillermo , Guillén Lucia , Botella Ángela , Muga Roberto , Sanvisens Arantza , Fuster Daniel , Berenguer Juan , Gutierrez Isabel , López Juan Carlos , Ramírez Margarita , Padilla Belén , Gijón Paloma , Aldamiz-Echevarría Teresa , Tejerina Francisco , Diez Cristina , Pérez Leire , Fanciulli Chiara , Corral Saray , Vidal Francesc , Martí Anna , Peraire Joaquín , Viladés Consuelo , Vargas Montserrat , Olona Montserrat , Rull Anna , Alba Verónica , Yeregui Elena , Masip Jenifer , García-Pardo Graciano , Bertomeu Frederic Gómez , Espineira Sonia , Montero Marta , Cuéllar Sandra , Blanes Marino , Tasias María , Calabuig Eva , Salavert Miguel , Fernández Juan , Segarra Inmaculada , González-García Juan , Delgado-Hierro Ana , Arribas José Ramón , Arribas Victor , Bernardino Jose Ignacio , Busca Carmen , Cano Joanna , Cardiñanos Julen , Castro Juan Miguel , Escosa Luis , Falces Iker , Herranz Pedro , Hontañón Victor , García Milagros , González-Baeza Alicia , Martín-Carbonero Ma Luz , Mayoral Mario , Mellado Ma Jose , Micán Rafael , de Miguel Rosa , Montejano Rocío , Montes Ma Luisa , Moreno Victoria , Ramos Luis , Rodés Berta , Sainz Talía , Sendagorta Elena , Valencia Eulalia , Blanco Jose Ramón , Pérez-Martínez Laura , Oteo José Antonio , Ibarra Valvanera , Metola Luis , Sanz Mercedes , Arazo Piedad , Sampériz Gloria , Dalmau David , Martinez Marina , Jaén Angels , Sanmartí Montse , Cairó Mireia , Martinez-Lacasa Javier , Velli Pablo , Font Roser , Xercavins Mariona , Alonso Noemí , Aiello Francesco , Rivero María , Piérola Beatriz , Goikoetxea Maider , Gracia María , Ibero Carlos , Moreno Estela , Repáraz Jesús , Navarro Gemma , Garcia Manel Cervantes , Isbert Sonia Calzado , Vilasaro Marta Navarro , Garcia Belen Lopez , de los Santos Ignacio , de los Santos Alejandro , Sanz Jesús , García-Fraile Lucio , Martín Enrique , Sánchez-Cerrillo Ildefonso , Calvet Marta , Barrios Ana , Bautista Azucena , Sáez Carmen , Ciudad Marianela , Gutiérrez Ángela , Moreno Santiago , del Campo Santos , Casado José Luis , Dronda Fernando , Moreno Ana , Pérez M. Jesús , Serrano Sergio , Vivancos Ma Jesús , Martínez-Sanz Javier , Vallejo Alejandro , Sanchez Matilde , Pérez-Molina Jose Antonio , Hermida José Manuel , Bernal Enrique , Alcaraz Antonia , Bravo Joaquín , Muñoz Ángeles , Tomás Cristina , Martínez Mónica , Villalba M. Carmen , García Federico , Martínez Clara , Hernández José , Medina Leopoldo Muñoz , Álvarez Marta , Chueca Natalia , Vinuesa David , de Salazar Adolfo , Fuentes Ana , Guirao Emilio , Viñuela Laura , Ruiz-Sancho Andrés , Anguita Francisco , Del Romero Jorge , Raposo Montserrat , Rodríguez Carmen , Puerta Teresa , Carrió Juan Carlos , Vera Mar , Ballesteros Juan , Ayerdi Oskar , Baza Begoña , Orviz Eva , Antela Antonio , Losada Elena , Riera Melchor , Peñaranda María , Ribas M. Angels , Campins Antoni A. , Garcia-Gazalla Mercedes , Fanjul Francisco J. , Murillas Javier , Homar Francisco , Vilchez Helem H. , Martin Luisa , Payeras Antoni , Santos Jesús , López María , Gómez Crisitina , Viciana Isabel , Palacios Rosario , López-Cortés Luis Fernando , Espinosa Nuria , Roca Cristina , Llaves Silvia , Tiraboschi Juan Manuel , Imaz Arkaitz , Silva Ana Karina , Saumoy María , Scévola Sofía Catalina , Curran Adrián , Falcó Vicenç , Navarro Jordi , Burgos Joaquin , Suanzes Paula , García Jorge , Descalzo Vicente , Álvarez Patricia , Planas Bibiana , Sanchiz Marta , Rodríguez Lucía , Olalla Julián , Sánchez M. José , Pérez Javier , del Arco Alfonso , de la Torre Javier , Prada José Luis , Martínez Onofre Juan , Martinez Lorena , Vera Francisco Jesús , García Josefina , Alcaraz Begoña , Guirao Antonio Jesús Sánchez , Mena Alvaro , Castro Angeles , Pernas Berta , Vázquez Pilar , López Soledad , Ibarra Sofía , García Guillermo , Mirena Josu , Ferrero Oscar Luis , López Josefina , Cámara M. Mar , de la Peña Mireia , Lopez Miriam , Lopez Iñigo , Lombide Itxaso , Polo Victor , de Miguel Joana , Galera Carlos , Fernández Marian , Albendin Helena , Castillo Antonia , Iborra Asunción , Moreno Antonio , Merlos M. Angustias , Vidal Asunción , Amador Concha , Pasquau Francisco , Gil Concepcion , Algado Jose Tomás , Suarez-García Inés , Malmierca Eduardo , González-Ruano Patricia , Ruiz M. Pilar , Pascual José Francisco , Sáez Elena , Balsalobre Luz , López M. Villa , Omar Mohamed , Herrero Carmen , Gómez M. Amparo , de Zarraga Miguel Alberto , Pérez Desiré , Estrada Vicente , Sanz Nieves , Cabello Noemí , García Jorge Vergas , Núñez Maria Jose , Sagastagoitia Iñigo , Górgolas Miguel , Cabello Alfonso , Álvarez Beatriz , Prieto Laura , Carrillo Irene , Sanz José , Arranz Alberto , Hernández Cristina , Novella María , Galindo M. José , Ferrer Ana , Román Antonio Rivero , Ruíz Inma , Juárez Antonio Rivero , López Pedro , Machuca Isabel , Frias Mario , Camacho Ángela , Pérez Ignacio , Corona Diana , Pérez Ignacio , Corona Diana , Cervero Miguel , Torres Rafael , Pineda Juan Antonio , Rincón Pilar , Macías Juan , Real Luis Miguel , Corma Anais , Fernández Marta , Gonzalez-Serna Alejandro , Poveda Eva , Pérez Alexandre , Morano Luis , Miralles Celia , Ocampo Antonio , Pousada Guillermo , Patiño Lucía , Dueñas Carlos , Gutiérrez Sara , Tapia Elena , Novoa Cristina , Egües Xjoylin , Telleria Pablo 
Published: October 2022

Acquired immunodeficiency syndrome (AIDS) is still one of the main health problems worldwide. It is therefore essential to keep making progress in improving the prognosis and quality of life of affected patients. One way to advance along this pathway is to uncover connections between other disorders associated with HIV/AIDS—so that they can be anticipated and possibly mitigated. We propose to achieve this by using Association Rules (ARs). They allow us to represent the dependencies between a number of diseases and other specific diseases. However, classical techniques systematically generate every AR meeting some minimal conditions on data frequency, hence generating a vast amount of uninteresting ARs, which need to be filtered out. The lack of manually annotated ARs has favored unsupervised filtering, even though they produce limited results. In this paper, we propose a semi-supervised system, able to identify relevant ARs among HIV-related diseases with a minimal amount of annotated training data. Our system has been able to extract a good number of relationships between HIV-related diseases that have been previously detected in the literature but are scattered and are often little known. Furthermore, a number of plausible new relationships have shown up which deserve further investigation by qualified medical experts.