bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficacy of sodium bicarbonate in treating lactic and non-lactic metabolic acidosis at different chloride levels
Authors: Wu Jian , Lai Ling , Xue Xiaoyan , Wu Shuiyan , Liu Huaqing
Published: October 2024

Background
The use of sodium bicarbonate to correct metabolic acidosis in patients is common in clinical practice, but the efficacy is still controversial. The aim of the study is to assess the efficacy of sodium bicarbonate in treating non-lactic and lactic metabolic acidosis, as well as its effectiveness at various chloride levels.
Methods
A retrospective cohort study was conducted by screening pediatric patients diagnosed with metabolic acidosis from PIC database. Patients were categorized into two groups: lactate patients (lactate > 2 mmol/L) and non-lactate patients (lactate ≤ 2 mmol/L). The risk of in-hospital and 28-day mortality for sodium bicarbonate treatment was assessed.
Results
A comprehensive analysis was conducted on a total of 5814 patients, with 3184 (54.76%) being lactate patients. In lactate patients, when chloride < 107 mmol/L, those who received sodium bicarbonate therapy exhibited a significantly elevated risk of both in-hospital mortality (adjusted OR = 2.195, 95% CI: 1.536–3.135, p < 0.001) and 28-day mortality (adjusted OR = 2.195, 95% CI: 1.434–2.989, p < 0.001). Conversely, when chloride ≥ 113 mmol/L, patients who received sodium bicarbonate had a decreased risk of in-hospital mortality and 28-day mortality, with adjusted OR values of 0.365 (95% CI: 0.217–0.614, p < 0.001) and 0.396 (95% CI: 0.232–0.675, p = 0.001), respectively. Similar findings were observed in non-lactate patients.
Conclusions
Regardless of lactate levels, sodium bicarbonate was effective in reducing the risk of death in patients with hyperchloremia, while increasing the risk of death in non-hyperchloremic patients.
Complementary and Alternative Medicine Use and its Impact on Quality of Life among Cancer Patients in Freetown, Sierra Leone: Considerations for a Resource-Limited Setting
Authors: Abiri Onome Thomas , Sheriff Matilda Seinya , Smalle Isaac Olufemi , Bell Nellie V.T. , Kamara Ibrahim Franklyn , Kamara Thaim B. , Cummings-John Constance , Coker Joshua , Bah Abdulai Jawo , Kanu Joseph Sam , Luke Ronita , Kamara Lannes , Smith John , Samai Mohamed
Published: October 2024

Background
Cancer patients are increasingly resorting to complementary and alternative medicine (CAM) to alleviate the effects of the disease and enhance their quality of life (QoL). However, to our knowledge, no study has investigated CAM use and its impact on QoL in patients with cancer in Sierra Leone. Therefore, this study aimed to assess the prevalence of and associated factors with CAM use, and compare the quality of life between CAM users and non-users.
Methods
Data were collected through face-to-face interviews, using an adapted questionnaire. This cross-sectional descriptive study was conducted at three health facilities in Freetown viz Connaught Hospital, Ola During Children's Hospital, and the Water and Stone Clinic. The QoL was assessed using the European Organization for Research and Treatment of Cancer tool. Descriptive analysis was employed and binary logistic regression tests were used to explore the factors associated with CAM use, with statistical significance set at p < 0.05.
Results
In total, 204 participants completed the study. The prevalence of CAM use was 48.5%. Among the various CAMs examined in this study, herbal medicines (48.8%) followed by special foods (19.4%) were the most commonly used forms of CAM. The primary reason for CAM use was the management of cancer complications (43.4%). Over half of the CAM users did not disclose their CAM use to their doctors (53.5%). There was a statistically significant association between CAM use and tertiary education (AOR = 2.68, 95%CI = 1.31–5.49, p = 0.007) and chemotherapy treatment (AOR = 1.91, 95%CI = 1.06–3.46, p = 0.032). There was no considerable impact of CAM on QoL, although financial difficulty was statistically significant among CAM users compared with non-CAM users.
Conclusion
This study revealed that CAM use is prevalent among patients with cancer, with herbal medicines being the most commonly used form, followed by special foods and prayers. Patients primarily obtain information about CAM from family, friends, and relatives, and most do not discuss CAM use with their doctors. Tertiary education and chemotherapy were found to be predictors of CAM use. Regarding the impact of CAM on QoL, only financial difficulty was statistically significant.
Proteomics and Transcriptomics Analysis of Emilia sonchifolia (L.) DC Antibacterial Activity against Methicillin-resistant Staphylococcus epidermidis
Authors: liu xin , An Lili , Chen Gongzhen , Ni Meng , Wang Xuebing , Fu yufeng , Zhou Yonghui , Yang Yuqi , Peng Wei
Published: October 2024

Background: Bloodstream infections (BSIs) are a public health concern and cause substantial morbidity and mortality. The pathogen Staphylococcus epidermidis causes a significant number of BSIs. Antibiotics targeting Staphylococcus epidermidis have been the mainstay in BSIs. However, conventional antibiotics have been eclipsed in combating with drug-resistant bacteria. Alternate ways of treating these antibiotic-resistant infections are thus urgently needed. Numerous studies have demonstrated that certain traditional Chinese medicine(TCM) exhibit notable antimicrobial activity and possess the ability to impede the development of bacterial resistance. Based on an extensive body of research in the field of TCM, it has been determined that the compositae plant exhibits a noteworthy anti-Methicillin-Resistant Staphylococcus Epidermidis (MRSE) effect. Thus, Emilia sonchifolia was used to explore the antibacterial activity againse MRSE.
Methods: Here, the objective of this study was to examine the antibacterial efficacy and underlying antibacterial mechanism of Emilia sonchifolia against methicillin-resistant Staphylococcus epidermidis( MRSE). The antibacterial activity of Emilia sonchifolia against MRSE was assessed through in vitro tests measuring minimum inhibitory concentration(MIC) and minimum bactericidal concentration(MBC).On the other hand, a mouse bloodstream infections of MRSE was used to evaluate the antibacterial activity of Emilia sonchifolia against MRSE in vivo . Furthermore, based on proteomics and transcriptomics were investigated to explore the underlying antibacterial mechanisms of Emilia sonchifolia against MRSE.
Results: The results showed that MIC and MBC values of Emilia sonchifolia against MRSE were 5mg/mL and 20mg/mL, respectively. Meanwhile, Emilia sonchifolia can effectively treat MRSE induced bloodstream infections.In addition, proteomic and transcriptomic data revealed a significant down-regulation of purine metabolism,which were associated with oxidative stress and cell wall synthesis. Furthermore,We determined imp, AMP and GMP by Elisa. The results showed that the contents of these enzymes all decreased, indicating that purine metabolism was inhibited. At the same time, SEM results showed that bacterial cell wall was destroyed.
Conclusions: Emilia sonchifolia exerts antibacterial effects by affecting purine metabolism, promoting bacterial oxidative stress and inhibiting bacterial cell wall synthesis. Thus, the aforementioned observations have contributed novel insights into the mechanistic understanding of Emilia sonchifolia's efficacy against MRSE, thereby offering potential strategies for managing MRSE infections.
Resolving Active and Spectator Species during the Oxidation of Carbon Monoxide over Pt(111) on the Microsecond Timescale
Authors: Shavorskiy Andrey , Eads Calley , Wang Weijia , Küst Ulrike , Prumbs Julia , Temperton Robert , Scardamaglia Mattia , Schnadt Joachim , Jnudsen Jan
Published: October 2024

Catalytic studies traditionally rely on steady-state conditions resulting in time-averaged datasets that do not differentiate between active and spectator species. This limitation can cause misinterpretations of catalytic function, as the signal of short-lived intermediates responsible for producing desired reaction products is often masked by more intense spectator species. Time-resolved ambient pressure X-ray photoelectron spectroscopy (tr-APXPS) mitigates this issue by combining microsecond time resolution under reaction conditions. Using tr-APXPS, we investigate the oxidation of CO over Pt(111) by concurrently tracking reaction products, surface intermediates, and catalyst response. Our findings reveal that chemisorbed oxygen, rather than Pt surface oxide, is the main species reacting with CO to form CO2, supporting a primary Langmuir-Hinshelwood mechanism. The results shed new light on a heavily-debated reaction in catalysis. Beyond using CO pulses to determine active species, we demonstrate how careful tuning of pulsing parameters can be used for dynamic catalyst operation to enhance CO2 formation.
Impact of surface roughness on consistent resonator performance
Authors: Karuppannan Senthil Kumar , Kommanaboina Naga Manikanta , Utama Adrian , Mukherjee Manas
Published: October 2024

Superconducting circuit-based quantum processors are leading platforms for quantum computing. In these circuits, microwave photons are stored as qubits in ultra-low-loss planar resonators and non-linear inductors formed by Josephson junctions. Resonators are typically made from high-energy-gap superconductors like Nb or Ta, while junctions are made of Al. Resonators occupy much of the circuit, making defect-free fabrication and understanding microwave energy dissipation crucial. Losses arise from noise, two-level systems (TLS), quasi-particles, and impurities. TLS losses dominate at operating temperatures below the critical temperature of the metal, whereas photon loss due to quasi-particles, often stemming from grain boundaries and pinholes in the metal film, becomes more pronounced at higher photon numbers or temperatures approaching the metal's critical temperature. To mitigate these, substrate cleaning, surface control, and non-superconducting film capping prevent oxide formation and reduce impurities. High-frequency drives, coupled with impurities at grain boundaries, lead to nonuniform quality factors among resonators. By controlling oxygen plasma exposure to minimize surface roughness and pinhole depth, we observed an area-dependent quality factor, which we attribute to changes in surface resistivity. This approach minimized variations in quality factors across resonators, improving uniformity in Nb-based devices and more consistent qubit readout performance.
LncRNA MALAT1 promotes METTL3-mediated m6A modification to promote progression in non-small cell lung cancer
Authors: Tian Shuhong , Ling Fayu , Fu Dunzhi , Wang Qiongyu , Li Fan , Li Biao
Published: October 2024

Objective: This study aims to examine whether lncRNA MALAT1 targets METTL3 and modulates its expression, subsequently influencing the expression of INPP5B and LRIG2 genes. Additionally, the research seeks to determine how these interactions regulate the tumor immune microenvironment and impact the progression of non-small cell lung cancer (NSCLC).
Methods: Non-small cell lung cancer cells (NCI-H226) served as the experimental model in this study. The cells were transfected with si-MALAT1 and OE-METTL3 constructs. Fluorescence in situ hybridization (FISH) was employed to determine the subcellular localization of MALAT1. Apoptosis was quantified using flow cytometry, whereas cell proliferation was assessed through the 5-ethynyl-2'-deoxyuridine (EDU) incorporation assay. The Transwell assay was utilized to evaluate cell migration capability and m6A methylation levels. Quantitative PCR (qPCR) and Western blot (WB) analyses were conducted to measure the expression levels of cancer-related genes. Furthermore, an RNA immunoprecipitation (RIP) assay was conducted to validate the interaction between MALAT1 and METTL3. To investigate the functional implications of this interaction, a BALB/c nude mouse subcutaneous xenograft model was utilized, wherein NSCLC cells with silenced MALAT1 expression were employed, both with and without the overexpression of METTL3.
Results: The MALAT1 is primarily localized within the nucleus. Under conditions of low expression, MALAT1 remains confined to the nucleus, whereas at elevated expression levels, it translocates to the cytoplasm. Following the application of siRNA targeting MALAT1 (si-MALAT1), a reduction in cell proliferation and migration capabilities was observed, although no significant change in cell colony formation ability was detected. Additionally, an increase in cell apoptosis was noted, with cells exhibiting arrest in the G0/G1 phase of the cell cycle. In parallel, the expression levels of MALAT1 and the oncogenic gene LRIG2 were both diminished, concomitant with a reduction in m6A methylation levels. Subsequent to the interference with MALAT1, transfection with a METTL3 overexpression vector led to a notable decrease in apoptosis, retention of cells in the S phase, and a significant downregulation of the tumor suppressor gene INPP5B. Results from the RIP assay indicated an interaction between MALAT1 and the MALAT1 protein. Furthermore, MALAT1 modulates the impact of METTL3 on the immune microenvironment of NSCLC tumors.
Conclusion: The long non-coding RNA MALAT1 facilitates the progression of NSCLC and holds potential as a novel prognostic biomarker and therapeutic target.
Design and modeling of process manufacturing-oriented digital twin system
Authors: Chen Jinshi , Zhao Yunlong , Huo Dongyang , Ma Zhigang , Xi Bo , Ma Caoyuan
Published: October 2024

The digital twin represents a significant direction for the digital transformation of factories. Traditional process manufacturing is characterized by limited real-time interaction and insufficient transparency, hindering effective monitoring of production data and delaying the timely response to production incidents. These limitations make it increasingly unsuitable for the demands of the digital age. This paper proposes a digital twin system for process manufacturing, developed based on a five-dimensional model, and explains the interaction process of the digital twin system from the perspective of data circulation. The development methods and key enabling technologies of the digital twin system are summarized. Using the coding production line as the research object, the data space, virtual space, and user space were constructed based on the Blender platform. Experimental results indicate that this system possesses functions such as remote monitoring, data analysis, remote control, process tracing, and VR interaction. This research establishes the groundwork for advancing the remote and autonomous operation of process manufacturing.
Treatment of neuropathic pain in leprosy patients with a physiotherapeutic protocol combined with photobiomodulation
Authors: Bonazza Dinorá Simone Santi , Duarte Vanessa Matias Souza , Lima Thiago da Rosa , Gomes Ciro Martins , Damazo Amílcar Sabino
Published: October 2024

Purpose: Leprosy, when diagnosed late, often leads to persistent complications, including neuropathic pain due to Mycobacterium leprae infection. This study aimed to apply a physiotherapeutic protocol combined with photobiomodulation as a non-pharmacological resource to reduce neuropathic pain and maintain functional capacity in leprosy patients.
Methods: A single-blind randomized clinical trial was conducted with 30 leprosy patients. Patients were randomly divided into two groups: physiotherapeutic protocol (PPG) and physiotherapeutic protocol combined with photobiomodulation (PPBMG). They were analyzed for pain scale (VAS), screening of activity limitation and safety awareness (SALSA), participation scale, and quality of life survey (SF-36).
Results: In the SALSA, a reduction in the number of patients with very severe limitation was observed in the PPBMG (effect size, 0.24). In participation scale, there was an increase in the number of patients without restrictions in the PPBMG. Regarding VAS, there was improvement in both groups (PPG, P=0.0061; PPBMG, P=0.041), with no difference between them. In relation to neurological evaluation by nerve palpation, there was improvement in the ulnar nerve condition (P=0.0244) in the PPG group, and in the fibular nerve (P=0.0425) in the PPBMG group. In the functional assessment, PPBMG patients showed statistical differences with improvement in the median (P=0.0281) and tibial (P=0.0267) nerves. In the SF-36, there was an increase in the domains of physical limitations (PPG, P=0.0273; and PPBMG, P=0.0078) and pain (PPG, P=0.0156; and PPBMG, P=0.0020; effect size, 0.34).
Conclusion: This study provides highly relevant evidence for the efficacy of PPBMG in treating neuropathic pain in leprosy patients.
Capabilities and Challenges Encountered by Barangay Officials of Selected Barangays in Dipolog City on Local Budgeting Process
Authors: ENERO FAITH MARIE , NAPAROTA LEO
Published: October 2024

The present political landscape of Dipolog City presented an interesting setting for the study. The researchers assessed the capabilities and challenges faced by barangay officials in connection with their sex, age, position, years of experience, and educational attainment. Extensive discussion on various legal frameworks governing the local budgeting process which allows barangay officials to participate were provided for contextualization. Sixty barangay officials in Dipolog City served as respondents of this quantitative research and findings indicate that barangay officials were much capable in all areas of the local budgeting process characterizing the phases of budget preparation, budget authorization, budget execution, and budget accountability. The capabilities of barangay officials were not significantly different depending on the respondent’s profile. The phases of budget preparation, budget authorization, and budget accountability were deemed by the respondents to be "moderately challenging," and categorized budget execution as "highly challenging". Barangay officials assessed the difficulties they encountered in creating the local budget to be "moderately challenging". Based on their sex, age, position, years of experience, and educational attainment, it was discovered that the respondents' opinions of the local budgeting process did not differ significantly from one another.
Paradoxical Structure of the Parergon in Kant and Derrida and its Relation to the Mystical and Artistic Revelation
Authors: Suciu Livia Georgeta
Published: October 2024

Polazeći od rizika kantijanske filozofije da sve zatvori unutar čvrstih granica sustava uma i isključi izvanjski, prijeteći ostatak onkraj tih granica, Jacques Derrida nastojao je dekonstruirati napor metafizike u izgradnji umjetnih mostova preko pukotina filozofijskih sustava, obično uzrokovanih probojem ovoga neupravljivoga izvanjskoga ostatka koje se podčinjava autoritetu metafizičkoga logosa. S obzirom na to da je u kantovsku sustavu taj izvanjski ostatak nazvan parergon, slijedili smo paradoksnu strukturu parerogna, najprije na osnovama mističko-religijskoga iskustva, a zatim na osnovama estetičko-umjetničkoga iskustva. Ističemo da Derrida obrće metafizičku perspektivu i argumentira da je parergon pouzdana, propusna, neodlučena granična struktura, nesvodivo upletena između svega što je zatvoreno unutar formalnih granica i a-formalnoga ostatka koje završi vani. Originalna derridaovska argumentacija dekonstruira razlikovanje između ergona i parergona i cjelokupnost metafizičkih opozicija te nas vodi prema neodlučivoj parergonalnoj granici.
The frequency of symptoms of reflux in the esophagus and triggers of heartburn
Authors: Shtygasheva O. V. , Ageeva E. S. , Emelyanov N. V.
Published: October 2024

Introduction. The heterogeneity of GERD pathogenesis determines the differences in diagnostic and therapeutic tactics. The personalization of therapy includes individual nuances of the metabolism of proton pump inhibitors and modification of risk factors: reduction of excess body weight, the abolition of tobacco smoking, alcohol intake, optimization of the pattern of eating behavior, the exclusion of drugs affecting the lower esophageal sphincter, normalization of the permeability of the mucous membrane of the esophagus.

Aim.  To investigate pathological changes in the esophagus according to endoscopic examination protocols and the frequency of factors predisposing to the occurrence of reflux symptoms in the esophagus.

Materials and methods. In retrospective study of the EGDS protocols (n = 208), esophagitis was assessed (Los Angeles classification, 1994) and at the same time, risk factors for heartburn were investigated by questionnaire in a hospital cohort of patients (n = 50). The analysis of these protocols and respondents’ responses took into account differences by gender and age (WHO).

Results and discussion. Among patients with convincing endoscopic signs of GERD in a random sample of EGDS protocols, men predominated. The frequency of detection of pathological changes in the esophagus associated with GERD was at the level of 19.5%, stage C esophagitis was recorded 2 times more often, while stage D esophagitis and Baretta esophagus were recorded only in men. Age-related patterns have been established: stage D esophagitis, Barette’s esophagus and peptic stricture of the esophagus were detected among elderly and senile patients. Among the triggers of heartburn, respondents most often chose a certain pattern of eating behavior. Obesity was a significant risk factor in women, while smoking and taking calcium channel blockers were significant in men.

Conclusion. Prolonged use of proton pump inhibitors is indicated in a limited proportion of patients suffering from heartburn. To diversify GERD therapy, diagnostic measures are needed to clarify the mechanism of reflux into the esophagus.
Comorbidity of inflammatory bowel diseases and periodontal pathology
Authors: Trukhan D. I. , Sulimov A. F. , Trukhan L. Yu.
Published: October 2024

Inflammatory bowel diseases, which include Crohn’s disease and ulcerative colitis, are a global disease of the 21st century. Periodontitis is the sixth most common disease in the world (second among dental pathologies after caries) and the leading cause of tooth loss in adults. At the beginning of the 21st century, the concept of “periodontal medicine” was formed, within the framework of which the bidirectional connection of periodontal pathology with systemic diseases of the body is considered. Extraintestinal manifestations of inflammatory bowel disease are associated with the generalized nature of the inflammatory response. In clinical guidelines, only aphthous stomatitis is described as a systemic manifestation of Crohn’s disease and ulcerative colitis from the oral cavity. Periodontitis is considered a less representative non-specific oral manifestation of inflammatory bowel disease. We searched the Pubmed and Scopus information databases for articles published before 02/15/2024 that examined the relationship between inflammatory bowel disease and periodontal pathology. The results of clinical studies, their synthesis in systematic reviews and meta-analyses, indicate a bidirectional relationship between Crohn’s disease and ulcerative colitis with periodontal pathology. The most likely mechanism is associated with a change in the microbiocenosis of the oral cavity and a further change in the intestinal microbiome due to oral intake of periodontal organisms, which leads to impaired intestinal permeability and the development of immune reactions that play a key role in the development of periodontal diseases and inflammatory bowel diseases.
Pedagógusból tanárképzővé válni – az identitáskonstrukció egy lehetséges értelmezési kerete és vizsgálati lehetősége
Authors: Tókos Katalin , Rapos Nóra
Published: October 2024

A tanárképzést érintő globális változások, szakpolitikai reformok, a hazai tanárképzés szabályozásának folytonos változása egyrészt egyes kérdéseket felerősít, másrészt új kérdéseket vet fel a tanárképzés szereplőinek szakmai identitáskonstrukciója kapcsán. A probléma tudományos igényű elemzése azonban még várat magára a hazai kontextusban. A változást okozó tényezők között azonosítható többek között a 2022-ben bevezetett Pályaismereti és pályaszocializációs gyakorlatok (8/2013. (I. 30.) EMMI rendelet), melynek kapcsán az iskolában dolgozó tanárok új csoportját vonták be a képzésbe, miközben kevéssé merült fel az ő tanárképzővé válásuk értelmezése és szakmai támogatása. Jelen tanulmányban e témában tervezett kutatásunk elméleti keretrendszerének megalapozására vállalkozunk. Egyrészt azzal foglalkozunk, hogyan értelmezhető a tanárképzővé válás mint tanulási- és egyben identitáskonstrukciós folyamat, melyben fontos szerepet tulajdonítunk a két fogalom kapcsolatának értelmezésének. Másrészt a kutatást megalapozó elméleti keretrendszer, modell leírására teszünk kísérletet.
Dynamic characteristics analysis of shock absorber based on fluid simulation
Authors: Li Ying , Yang Ran
Published: October 2024

Pneumatic spring dampers are extensively utilized within hydraulic systems, and the flow characteristics of the internal oil play a crucial role in determining noise and vibration levels. To validate the mechanical structure's reliability, the shock absorber was simplified and the fluid domain was extracted using a CFD method. The velocity field and pressure field under different conditions were then simulated and analyzed. A finite element model of the flow field was established, and its accuracy was verified by comparing simulation results of gas side pressure with experimental results. According to the working principle of the oil-gas spring, dynamic active surfaces in contact with the main piston and dynamic driven surfaces in contact with the floating piston were defined, determining moving conditions for dynamic grids. The results indicate that as the diameter of flow channels increases, there is a decrease in average pressure drop within the oil chamber (i.e., pressure loss within the flow field). Additionally, as bend angle increases, average pressure drop decreases. However, optimization effects become less significant beyond a certain bend angle.
Finite element analysis of rockfall impact on pipelines with different erosion resistant coatings
Authors: Zu Yue , Zhang Xu , Liu Jiufa , Zhang Yunchao , Ding Qi , Jia Zhenfa , Yang Xiaoyan , Chen Zhen
Published: October 2024

In this paper, the finite element analysis method is used to extensively study the response of rockfall impact on pipelines with different erosion resistant coating. Based on the numerical results, the safety of the pipeline is comprehensively evaluated. Firstly, through the establishment of detailed pipeline and rockfall models, the impact of different rockfall materials and speeds on the pipeline is simulated. The results of the finite element analysis indicate that rockfall impact can cause significant stress concentration and deformation in the pipelines and damage to the coating. With the increment of impact speed, the damage to the pipeline also increases significantly, and different rockfall materials exhibit varying damage conditions, and it is found that fibreglass reinforced epoxy is better than the polyethylene coating. By comparing the analysis results under different conditions, the safety threshold of the pipeline under various rockfall impact scenarios is obtained. This provides an important theoretical basis and reference for the protection design and safety maintenance of the pipeline. The research in this paper not only aids in deepening the understanding of the mechanism of rockfall impact on pipelines but also serves as a valuable reference for improving the safety and reliability of pipeline engineering.
Analysis and optimization of the dynamic response characteristics of aircraft cargo rack
Authors: Zhang Zheng , Wang Chunxiang , Zhang Qi
Published: October 2024

In order to effectively achieve the optimization design of the aircraft cargo rack, based on finite element modal simulation, the structure was redesigned and analyzed using two schemes of surrogate model size optimization and topology optimization, ensuring the strength requirements while improving the natural frequency and reducing the weight. According to the modal shape of vibration, additional bridge structures were added at the weak points to improve the dynamic stiffness of the structure. According to the optimization design requirements, the response surface function was constructed, and the particle swarm optimization algorithm was applied in the size optimization and surrogate model solution. A multi-objective optimization model was established for flexibility and low-order natural frequencies, and topology optimization was carried out in HyperWorks. The structural dynamic modification of the topology optimization model was performed using the modal strain energy analysis method. The research results show that both optimization methods can achieve good lightweight design. The static performance of the optimized structure is stable, and the overall modal frequency is improved.
Analysis of aerodynamic characteristics of drone wing based on CFD
Authors: Wang Chunxiang , Zhang Zheng , Zhang Qi
Published: October 2024

In order to improve the aerodynamic characteristics of the drone wings, CFD method was used to simulate and calculate the lift coefficient, drag coefficient, and lift-drag ratio under different relative inflow velocities, as well as the velocity and pressure fields under different attack angles. Modal calculations were conducted on the wing to obtain the first four modal shapes, providing a basis for analyzing flutter characteristics. An iterative calculation method of incompressible potential flow-boundary layer based on surface element method was combined with the software XFOIL to optimize the airfoil at low wind speeds. The results indicate that the airfoil is susceptible to stall at high angles of attack, with the pressure of the separation flow being nearly equivalent to that at the separation point. Subsequent to separation, there is an increase in differential pressure resistance, resulting in a marked rise in the drag coefficient. At the optimized angle of attack, the lift-drag ratio of the optimized wing increases by 12.58 %, while there is a decrease of 0.084 % in lift coefficient and an increase of 11.21 % in drag coefficient.
Modal analysis and optimization design of ultra-high acceleration platform rail frame
Authors: Zhang Zhiyuan , Zhang Jian , Zhang Sen
Published: October 2024

The ultra-high acceleration macro and micro motion platform has the advantages of high positioning accuracy and small error, and the key mechanism rail frame of the ultra-high acceleration macro and micro motion platform is optimized based on modal analysis to achieve the performance optimization of the platform. SolidWorks software was used to build the rail frame model, and ANSYS Workbench software was used to carry out modal analysis, topology optimization and response surface optimization, etc., so as to reduce the quality of the rail frame as much as possible under the premise of maintaining the stability of the first-order natural frequency. The results show that the optimization of the response surface meets the expected goal, the first-order natural frequency of the guide rail frame increases by 0.7 %, the mass decreases from 6.165 kg to 5.592 kg, and the change rate is 9.2 %, which achieves the purpose of lightweight.
Demagnetization optimization of hybrid excitation eddy current damper under intensive impact load
Authors: Wu Xiang , Yang Guo Lai , Li Lei , Chu Yan Tao , Wang Xiu Ye , Suo Hao
Published: October 2024

The hybrid excitation eddy current damper is a novel principle damper characterized by high reliability, simple structure, and controllable magnetic field. Under intensive impact loads, hybrid excitation electromagnetic damping can induce demagnetization effects, resulting in significant fluctuations of the electromagnetic damping force at 6-8 ms. To mitigate this phenomenon, this study established a finite element model of the hybrid excitation damper using COMSOL and developed a control module based on a BP neural network in Simulink. Through co-simulation of COMSOL and Simulink, the difference between the maximum and minimum electromagnetic damping force at 6-8ms is reduced from 45 kN to 5 kN. This research provides valuable technical references for the optimization and practical application of eddy current dampers.
Reliability analysis of cable crimping terminals with different applicator tools
Authors: Dacian Ilca , Tiberiu Manescu , Cristian Tufisi
Published: October 2024

This study provides a comprehensive evaluation of the stability of crimping of the same terminal on FLRY A cables using three different applicators. The research involved conducting pull tests on 50 samples for each applicator type, analyzing the results using Minitab software to assess the consistency and strength of the crimp connections. The findings indicate that while the Demirel applicator produces the highest average pull test values, the Tyco applicator demonstrates superior consistency, making it more suitable for applications where process stability is critical.
Physiological characteristics of microbial transformation during chronic exposure to triclosan as a hydrophobic antibacterial agent and post-antibacterial cessation
Authors: Nguyen T. H. , Fujino Takeshi
Published: October 2024

The use of triclosan (TCS) in hygiene products and other materials raises concerns about increased antimicrobial resistance. Research has shown that bacteria can develop resistance to TCS, but there is limited understanding of how bacterial behavior changes after TCS is removed. This study focuses on how bacteria adapt to prolonged TCS exposure and recover after its removal. It aims to improve practices for using antimicrobial agents in sanitation products and emphasize the importance of understanding exposure and recovery times to prevent resistance development. The study evaluated the bacterial behavior, determining the minimum inhibition concentration of TCS that 90% of Escherichia coli was inhibited (MIC90), predicting bacterial growth kinetics using the Modified Gompertz model and membrane permeability recovery. Bacteria showed a significant increase in resistance levels during exposure, with the MIC90 steadily increasing over 30 days and peaking at 16 mg/L. Upon removal, there was a notable 2-fold decrease in resistance after 10 days of reculturing in a non-chemical medium, likely due to restructuring changes in cell membranes. Therefore, in addition to reducing the occurrence of antibacterial agents in the environment, advanced treatments for eliminating antibacterial resistance should be performed on wastewater before being discharged into the environment.
Refinamiento de la Escala de Desregulación Emocional (DERS-16): Dimensionalidad, Consistencia Interna y Funcionamiento Diferencial por Género
Authors: Espitia Correa Joseph , Caballero Domínguez Carmen Cecilia , Campo Arias Adalberto
Published: October 2024

La regulación emocional ha evidenciado una gran importancia en la salud mental de las personas por lo cual se han diseñado instrumentos para la medición. La Escala de Dificultades en la Regulación Emocional (DERS) es un instrumento con una conceptualización integradora. Sin embargo, el número de ítems y el limitado desempeño psicométrico han llevado al desarrollo de nuevas versiones con diversa extensión. El estudio tuvo como objetivo fue refinar una versión de 16 ítems de la DERS en adultos colombianos mediante la dimensionalidad, la consistencia interna y el funcionamiento diferencial de los ítems por género (DFIG). Se diseñó un estudio en línea en el que participaron 435 adultos con edades entre 18 y 79 años (M = 35,30; DE = 14,13), 70,57% de género femenino. Se llevó a cabo un análisis factorial confirmatorio para corroborar la dimensionalidad, se calculó la consistencia interna mediante los coeficientes de alfa de Cronbach, omega de McDonald y el DFIG mediante la tau-b de Kendall. La versión de 16 ítems mostró pobres indicadores de dimensionalidad y consistencia interna. El refinamiento logró una versión de diez ítems distribuidos en dos dimensiones, con alta consistencia interna y sin DFIG.
Structure-Activity Relationship of Substituted Pyrazoline Derivatives as Small Molecule Tyrosine Kinase Inhibitors
Authors: Akbar Saleem , Das Subham , Mahto Aman Kumar , Dewangan Rikeshwer Prasad , Ahmed Bahar
Published: October 2024

Background:

Tyrosine kinase inhibitors (TKIs) target certain cell signalling pathways, and have become a promising class of medications for the treatment of cancer in recent years. Because of their distinct structure and adaptable chemistry, pyrazolines have drawn a lot of interest from organic and medicinal chemists. Their exceptional TKI activity has prompted them to investigate chemotherapy for cancer.

Objective:

We aim to develop agents that inhibit tyrosine kinases highly effective with the least amount of harm possible, perhaps improving the course of cancer treatment.

Methods:

This review compiled current information from recent literature sources, includ-ing in vitro, in vivo, approved medications, active clinical trials, and the structure-activity relationships (SAR) linked to various pyrazoline analogues used as small-molecule Tyro-sine Kinase Inhibitors in cancer treatment.

Results:

This study focuses on SAR inside the pyrazoline ring and its derivatives as TKIs, and it emphasizes current developments, including patents, authorized medications, and compounds in clinical trials.

Conclusion:

By enhancing our understanding of these compounds, our goal is to aid in making the roles of pharmacologists, scientists, and researchers who are designing and developing next-generation anticancer drugs with pyrazoline scaffolds easier. The future holds immense potential for the continued evolution of pyrazoline-based therapies, offer-ing renewed hope in the ongoing battle against cancer.
Exosomal circRNAs: The Key Role and Potential Therapeutic Target in Gastric Cancer
Authors: Jin Yong , Wang Jingjing , Zhang Chunwei , Li Jingjing , Wei Chengyan , Zhou Yuanzhi
Published: October 2024

A ring-stabilized endogenous non-coding RNA is called circular RNA (circRNA). Intercellular communication is mediated by exosomes, and circRNA is enriched and stabilized in exosomes. It has recently been demonstrated that cancer cells and tissues exhibit abnormal expression of exosomal circRNAs. By controlling angiogenesis, metabolism, metastasis, epithe-lial mesenchymal transition (EMT), tumor chemoresistance, immune evasion, and cell prolifera-tion, it may also have an impact on the development of different malignancies. Furthermore, ex-osomal circRNAs have strong tissue selectivity, stability, and other qualities that make them useful for diagnostic purposes. Consequently, exosomal circRNAs offer a wide range of poten-tial applications in the therapy of cancer and can be utilized as biomarkers and anti-tumor tar-gets. The features and purposes of circRNAs and exosomes are briefly discussed in this review, which also methodically explains the function and possible mechanism of the function of exo-somal circRNA in the onset of gastric cancer (GC). Furthermore, their clinical uses as targets and biomarkers for gastric cancers are also summarized and discussed in this work.
Ongoing Clinical Trials for Polycystic Ovarian Syndrome (PCOS) Afflicted Infertility in Women: A Narrative Review
Authors: Shukla Ratnakar , Chadha Muskan , Adya Anisha , Yadav Aastha , Singh Nidhi , Chauhan Ranjeet Singh , Ahmad Afza , Tiwari Rohit Kumar
Published: October 2024

Polycystic Ovary Syndrome (PCOS) is a highly prevalent endocrine disorder that affects
women of reproductive age. PCOS is further correlated with infertility, menstrual dysfunction,
and hyperandrogenism. Despite the advanced understanding of reproductive biology, the exact
causes of PCOS remain ambiguous. Nevertheless, several factors are believed to contribute to
the development of PCOS, including insulin resistance, hyperinsulinemia, obesity, and genetic predispositions.
The diagnosis of PCOS is complicated by its phenotypic heterogeneity, which manifests
differently in different individuals. Presently, the therapeutic management of PCOS-afflicted
infertility depends upon proper pharmaceutical-based therapies aimed at treating underlying symptoms,
such as the use of clomiphene citrate, metformin, ovulation-inducing agents, anti-androgens,
exogenous gonadotropin administration, laparoscopic ovarian drilling, and in vitro fertilization.
The present review focuses on narrating present therapeutic interventions along with lifestyle
modifications in PCOS. Furthermore, it focuses on the ongoing clinical trials of various chemotherapeutics
to counter PCOS-induced infertility among women.
Hydrogels Innovation: A Review on Recent Development, Characterization, and Applications
Authors: Ahirwar Vikram , Jain Dharmendra
Published: October 2024

Hydrogels are special materials that can hold a large amount of water and form 3D networks.
In the past few years, there have been exciting improvements in hydrogel technology,
bringing new ideas to many different areas. By trying out new materials like smart hydrogels that
can respond to different conditions, provided new ways to deliver medicine precisely, build tissues,
and create wearable gadgets. Among the most significant developments is the creation of
smart hydrogels, which can react dynamically to different environmental stimuli. With their ability
to release therapeutic chemicals under regulated conditions in response to particular physiological
cues, these intelligent materials have enormous potential for the administration of precision
medicine. These kinds of customized drug delivery systems have the power to completely change
how treatments are administered by reducing adverse effects and increasing therapeutic efficacy.
Hydrogels are also useful in tissue engineering, where they are used as scaffolds to create biological
tissues that function. Hydrogel-based tissue constructions, which imitate the extracellular matrix,
offer a favorable microenvironment for cell proliferation and differentiation, promoting the
healing of injured or ill tissues. With its enormous potential in regenerative medicine, this revolutionary
strategy offers hope for the treatment of ailments including organ failure. this article gives
a thorough look at the recent developments in hydrogels, characterization techniques, and the new
application of hydrogels in various fields of science.

In summary, new developments in hydrogel technology have opened up a plethora of opportunities
in a variety of scientific fields. The adaptable properties of hydrogels continue to spur innovation
in a variety of fields, including wearable technology, tissue engineering, and precision
medicine. These applications offer revolutionary answers to urgent social issues.
A pantera: dos bestiários ao Orto do Esposo
Authors: Sousa Camila
Published: October 2024

This paper will present part of my ongoing PhD research concerning the representation of the figure of the panther in selected medieval works. It is centered around a thirteenth-century bestiary and the Portuguese work Orto do Esposo, written in the late-fourteenth century or early fifteenth century. Bartholomew the Englishman’s work, De proprietatibus rerum, written in 1240 AD, works as a mediator between the information present in the bestiaries and that of Orto do Esposo. The relationship between the two will be explored and clarified in subsequent work, namely through the transcription and translation of passages from a copy of De proprietatibus rerum, from the Alcobaça Monastery (Alc. 383).
Correlation of Wellness Program Against Degenerative Indicators Through Experimental Pre-Posttest
Authors: Suandy Suandy , Susianto Susianto , Handoko Erwin , Luwis Kevin , Sanoesi Vindelin
Published: October 2024

The incidence of degenerative diseases, such as hyperuricemia, hypercholesterolemia, obesity, hypertension, and diabetes mellitus, is increasing, primarily due to unhealthy lifestyles. Holistic treatment, involving pharmacology and lifestyle modification, is recommended. The Wellness program, covering diet, exercise, and relaxation techniques like meditation and yoga offers a holistic approach to reduce the incidence of degenerative diseases. Adopting a Wellness program could have positive outcomes, including cost-effectiveness, nutritional balance, and improvements in both physical (through yoga) and mental (through meditation) well-being, but the potential downsides include lack of control groups, inadequate consideration of age and gender, insufficient sample sizes, limited observation days, and an excessive number of measured parameters. This study aims to see the effectiveness and influence of the Wellness program on reducing uric acid levels, cholesterol, blood sugar levels, systolic and diastolic blodd pressure. The intervention is designed for women aged 30-60 who experience rage. However, individuals who are consuming medications or supplements, pregnant, breastfeeding, or not following a prescribed diet are excluded. This study used the quasi-experimental pre-posttest design to see the Wellness program’s effectiveness on uric acid, blood pressure, blood sugar levels, and total cholesterol. Sample size calculation was performed using G*Power version 3.1.9.7, and data analysis utilized the T-paired sampled test. The findings from a 3-day study involving 47 participants revealed significant differences post-implementation of the Wellness program, indicating a reduction in uric acid levels and an increase in blood sugar levels with a p-value<0.05.
Guitarristas portugueses e seus descendentes estabelecidos no Brasil entre 1875 e 1975: Maria Lívia São Marcos
Authors: Fernandes Vinicius , Rodrigues Pedro
Published: October 2024

Este texto propõe divulgar os resultados parciais da investigação em curso sobre as atividades artísticas e pedagógicas de guitarristas portugueses e seus descendentes estabelecidos no Brasil entre 1875 e 1875. Os dados e documentos coletados na revisão da literatura, em repositórios e acervos digitais brasileiros e portugueses, demonstraram que Maria Lívia São Marcos – pertencente ao grupo de descendentes - ocupou lugar de destaque no desenvolvimento artístico da guitarra clássica no Brasil, com atuações relevantes no campo do ensino, da performance e da produção fonográfica. Pretende-se, assim, apresentar informações que contribuirão com a composição da memória artística e pedagógica de Maria Lívia São Marcos e, consequentemente, com os estudos sobre o percurso histórico da guitarra clássica no Brasil e suas conexões com Portugal.
As guitarras fabricadas no norte de Portugal entre 1799 e 1926
Authors: Soares Eduardo Daniel Martins
Published: October 2024

As guitarras portuguesas tal como as conhecemos hoje em dia são o resultado de modificações operadas em outras tipologias instrumentais durante as primeiras décadas do século XX e encontram-se profundamente associadas a um género musical. Como seriam, então, as guitarras antes da guitarra? E quais os seus contextos de utilização? As evidências materiais apontam para a existência, no norte de Portugal, de uma grande variedade de guitarras, desde guitarras inglesas, guitarrões, cithralias, cítaras campeiras e, claro, guitarras portuguesas. Cada uma delas com dimensões, características morfológicas, materiais, número de cordas, técnicas de execução e sobretudo, contextos de utilização singulares. Ao longo do artigo será possível refletir sobre a ascensão da guitarra enquanto instrumento nacional, enumerar, descrever e caraterizar as diferentes tipologias instrumentais encontradas e finalmente enquadrar o seu fabrico no contexto da violaria europeia, destacando os aspetos mais originais dos instrumentos construídos no norte de Portugal.