bluuebunny/crossref_metadata_2025 huggingface dataset:
Constrution Strategies on Metri Strutures for Similarity Searh
Authors: Uribe-Paredes Roberto , Márquez Claudio , Solar Roberto
Published: November 2018

The List of luster LC is an eetive tehnique to index high dimension metri spaes. LC is an array-type struture for similarity searh based on lustering. Sparse Spatial Seletion SSS is a new struture based on pivots for similarity searh in metri spaes. This array-type struture has shown good performane during the searh as ompared to other methods. This work shows dierent onstrution strategies on LC ; for instane, the use of SSS as a general seletion method of pivots or enters, among others. The artile also shows the advantages of the use of other tehniques like keeping the distane between the ob jets and the luster enter, apart from revising the eets of reursive appliation of suh methods. Finally, the inuene of the use of Voronoi partitions for the distribution of the ob jets within the struture will be shown. Preliminary experimental results show that the new versions of LC have a better performane in terms of distane evaluation than the original data struture and other renowned strutures. Keywords: Databases, Data strutures, Algorithms, Metri Spaes, Similarity Searh.
Selecting a Video Format to Support Teaching of Swimming
Authors: Solar Mauricio , Ducoing Eugenio , Contreras Fernando
Published: November 2018

A computer application that supports the teaching and learning of sportingtechniques is presented. It was developed as a tool to assist sports trainers in identifying,analyzing, relating, and evaluating the learning of sporting techniques. At times trainers fail tovisualize all the details of an athlete’s technical gestures, mainly because of the speed of themovements. Based on this concept of observational method, the developed software is simpleto use and includes digital videos in a natural form for trainers who are not computer experts.To select an adequate video format for analyzing sporting techniques, compression tests andvideo compression with different codecs were made. Once the format had been chosen, itscompression was tested at different video qualities with the selected codec. To verify thefunctionalities of the developed tool, the chosen sport was swimming. The results obtainedwith the tool had excellent usability, since most of the functions were mastered withoutproblems by the trainers.
A method to define process capability profiles from the characteristics of very small software enterprises
Authors: Schwening Cristiano , Thiry Marcello
Published: November 2018

This work presents a method for the definition of process capability profiles lined up with the specific business model of small software companies. The developed method is made up of a process, artifacts and guides that assist to obtain process profiles, considering the specific characteristics (business model, enterprise growth stage and value discipline) of each small software company. Therefore, the application of the method allows selecting a set of adjusted processes and lined up with the business model offering more objective improvement actions to a small software company. Partial results obtained during a pilot evaluation of the method in a small software company in Florianópolis/SC are also presented.

Keywords: process capability profile, software process improvement, capability model, business model, small business, very small enterprises.
Practices and Techniques for Engineering Process Capability Models
Authors: Salviano Clenio F. , M. Martinez Márcia R. , Zoucas Alessandra , Thiry Marcello
Published: November 2018

Software Process Improvement, based on a Maturity Level or a Process Capability Profile, from a Capability Maturity Model or an ISO/IEC 15504-based model, is well established in the software industry as a successful practical means for improving software intensive organizations. In consequence there is an opportunity to understand how these models have been developed and consolidate this knowledge to support the development of new models by a broader community including the industry. This article introduces practices and techniques of a Method Framework for Engineering Process Capability Models as an element of a methodology on a Process Capability Profile to drive Process Improvement. This method framework is based on previous experiences to develop different process capability models. Its current version is composed of sequential practices, customization rules, guidelines for using the framework, a repository for examples of utilization and another repository for examples of techniques. This method framework is part of a methodology. An initial validation indicates a first confidence that this method framework is a useful proposal for developing methods and processes for engineering process capability models.
Mapping Process Capability Models to Support Integrated Software Process Assessments
Authors: Thiry Marcello , Zoucas Alessandra , Tristão Leornardo
Published: November 2018

Software process assessments have been used to verify the conformance with quality reference models or standards, usually in a context of software process improvement programs. Most of these assessments are concerned with just one specific model or standard. However, organizations could be interested in more than one model, being necessary to offer an integrated assessment that allows evaluate the conformance with different models at the same time, reducing time and costs. To do this, it is necessary to have some kind of mapping among the models to permit some level of automation. In this context, this paper presents a method to mapping process capability models and standards, including its application. A software tool is also presented to demonstrate how to use the resulting mapping in a real life situation.
Synchronous versus Asynchronous interaction between users of two collaborative tools for the production of Use Cases
Authors: Fuenzalida Carlos M. , Antillanca Héctor B.
Published: November 2018

The performance of requirement engineers in the production of Use Cases is analyzed and compared using a collaborative editor in synchronous mode versus one in asynchronous mode, with the objective to learn which mode allows generating better specification documents for specific software. For this purpose some Use Cases were produced under a quasi-experimental approach. There were proposed eleven metrics, used to evaluate the cases generated in both modes, according to some desirable features. The attained results show that the Use Cases asynchronously produced hold a better quality. On the other hand, the synchronously-generated Use Cases take less time in their production than the asynchronously-generated ones.
A Two-level Calculus for Composing Hybrid QVT Transformations
Authors: Pons Claudia , Giandini Roxana , Pérez Gabriela , Baum Gabriel
Published: November 2018

The standard for model transformations QVT offers two dialects: Relations Language andOperational Mappings Language. Each one of these dialects can be used in isolation, resulting inpurely declarative transformations or purely imperative transformation respectively; alternatively, bothdialects can be combined resulting in a hybrid transformation approach. On the other hand, theavailability of compositional approaches to produce complex transformations from smaller units is amajor concern in the area of model transformations. Compositional approaches for pure QVTtransformations are supported by a number of tools; however no composition technique exists that canconsistently manage the hybrid approach. Such partial techniques provide suitable answers to mostpractical needs; but they do not cover the entire composition spectrum. The aim of this article is todescribe a technique for composing model transformations embracing both dimensions - declarativeand imperative - so that the hybrid approach can be smoothly supported. Additionally, we report theimplementation of a software tool supporting such technique and we sketch its validation.
Typing Textual Entities and M2T/T2M Transformations in a Model Management Environment
Authors: Vignaga Andrés
Published: November 2018

Global Model Management (GMM) is a model-based approach for managing large sets ofinterrelated heterogeneous and complex MDE artifacts. Such artifacts are usually representedas models, however as many Domain Specific Languages have a textual concrete syntax,GMM also supports textual entities and model-to-text/text-to-model transformations whichare projectors that bridge the MDE technical space and the Grammarware technical space. Asthe transformations supported by GMM are executable artifacts, typing is critical forpreventing type errors during execution. We proposed the cGMM calculus which formalizesthe notion of typing in GMM. In this work, we extend cGMM with new types and rules forsupporting textual entities and projectors. With such an extension, those artifacts mayparticipate in transformation compositions addressing larger transformation problems. Weillustrate the new constructs in the context of an interoperability case study.
Incorporation of "Kinesthetic Learning Activities" to Computer Science 1 course: Use and Results
Authors: Friss de Kereki Inés P.
Published: November 2018

In this work, we present the systematic incorporation of Kinesthetic Learning Activities (activities with movements and sensations), into the Computer Science 1 course. We detail the different activities and their use in the course. We evaluate student results in relation to their final grades in the course. Moreover, we include opinions of students that participated in the experimentation. Based on students' results, we appreciate a higher degree of course achievement, that is, students who achieve an exceptional result (86% or more points) in comparison with traditional courses.
Logic Programming: Can the learning and teaching process be improved apart from standards adopted by most professors and established in academic books?
Authors: B. L. Campos Ricardo Luiz
Published: November 2018

Logic programming is one of the most important subjects for students pursuing a degree in Information Technology and Communication (ITC) at higher education institutions. Teaching logic programming is considered one of the seven greatest challenges of computer science education in this century due to the high rate of failure among students, and because it directly influences how students will perform in other related subjects for the remainder of their program. Therefore, researching new strategies such as the ERM2C methodology is essential for improving education in the area. The methodology proposes that the process be developed in two stages: the first for reading/understanding any algorithm, and the second for building total or partial logic to solve problems. The methodology is still in the validation process, but the results obtained so far have been considered satisfactory.
Teaching Programming Principles through a Game Engine
Authors: Hernandez Cristiane Camilo , Silva Luciano , Alencar Segura Rafael , Schimiguel Juliano , Paradela Ledón Manuel Fernandez , Mendes Bezerra Luis Naito , Frango Silveira Ismar
Published: November 2018

Teaching fundamental programming to freshmen is a hard task to be performed, given the high level of abstraction and logical reasoning that are required for these students to develop in a very early stage of their course. This paper presents a discussion about this topic, along with a case study where computer games are meant to be developed by students in a first programming course, through the use of a game engine which allow students to develop fundamental programming skills without having to learn syntax and idiosyncrasies of any programming language.
Design, Implementation and Use of a Remote Network Lab with Multiple Users Support as an Aid Teaching Computer Networks
Authors: Aravena Marco , Rodriguez Cristian , Ramos Andres
Published: November 2018

This article presents the design, implementation and use of a remote network lab with multiple users support as an aid to teaching computer networks. The purpose is to enable multiple students complement their theoretical learning with practical experimentation in networking devices which can be carried out synchronously to theoretical classes and from any room with internet access. Unlike the current solutions based on mainly software emulation and simulation, the students interact remotely with commercial network devices, such as cutting-edge and widely used switches, routers and firewalls at the workplace. This proposal reduces the expenses or installing new laboratories in all the campuses where lectures are held and also moving the students to laboratories that are not located near their classrooms. The use of the remote laboratory has been tested with senior students majoring information technology engineering. The results shows that a remote network lab is an effective aid for teaching computer networks in a remote and secure way.
Professional Training Program Management through Holonic Networks
Authors: Montilva Jonás , Rivero Milagro , Barrios Judith , Besembel Isabel , Sandia Beatriz , Martinez Ana
Published: November 2018

Holonic networks constitute a type of organizational structures widely used at manufacturing enterprises. In an educational context, however, this type of structures remains practically unknown. The purpose of this paper is to demonstrate the applicability of these organizational structures to the design of professional training programs. Thus, we have herein proposed a conceptual model for holonic organizations that captures the structure and characteristics of this type of organizations. The use of this model is illustrated through the design of an academic organization devoted to professional training programs on Software Engineering. This paper describes the use of the combination of Holonic Networks and Business Models techniques for modeling complex organizational systems.
An educational methodology based on the work of students
Authors: Da Rosa Sylvia , Gómez Frois Federico
Published: November 2018

In the year 2006 the “Instituto Universitario Autónomo del Sur” decided to introduce a modification in the curricula of its Computer Science careers. Such modification was based on the guidelines of the Bologna process, particularly on the adoption of a credit system similar to the ECTS (European Credit Transfer System). The authors of this article saw this institutional decision as an opportunity to enhance an educational reform. The reform would modernize undergraduate programs, by establishing that students would have a main role in the educational process. This goal may only be achieved by a transformation of traditional teaching practices. Therefore, teachers, students and the institution have to undergo a process of deliberation and creation. In this article, the authors describe the process applied to the teaching staff, and the application of an innovative methodology developed for the first course of Programming. Extracts of interviews to students are also included.
Quality Improvement in Annotated Code
Authors: A. Correia Diego A. , Guerra Eduardo M. , Silveira Fabio F. , Fernandes Clovis T.
Published: November 2018

In order to customize their behavior at runtime, a wide sort of modern frameworks do use code annotations at the applications‟ classes as metadata configuration. However, despite its popularity, this type of metadata definition inserts complexity and semantic coupling that is ignored by traditional software metrics. This paper presents identified bad smells in annotated code and defines new metrics that help in their detection by enabling a quantitative assessment of complexity and coupling in this type of code. Moreover, it proposes some strategies to detect those bad smells by using the defined metrics and introduces an open-source tool created to automate the process of bad smell discovery on annotated code.
Adoption of Configuration Management in the Industry: Strategies and Lessons Learned
Authors: Werner Cláudia , Corrêa Chessman , Santos Rodrigo , Schots Marcelo , Murta Leonardo , Lyra Flávio
Published: November 2018

Maintenance represents an important activity in software industry as it is the one that takes the biggest effort among Software Engineering activities apart from its high cost. In this sense, software configuration management helps to overcome some difficulties related to software maintenance such as the lack of product knowledge and negligence in maintenance activities. This paper presents a configuration management deployment process based on standardization of practices and tools, taking into account the software development organizational culture. The results of its application in an industrial case are discussed.
3D-Via Driven Partitioning for 3D VLSI Integrated Circuits
Authors: Sawicki Sandro , Wilke Gustavo , Johann Marcelo , Reis Ricardo
Published: November 2018

A 3D circuit is the stacking of regular 2D circuits. The advances on the fabrication and packaging technologies allowed interconnecting stacked 2D circuits by using 3D vias. However, 3D-vias can impose significant obstacles and constraints to the 3D placement problem. Most of the existing placement algorithms completely ignore this fact, but they do optimize the number of vias using a min-cut partitioning applied to a generic graph partitioning problem. This work proposes a new approach for I/O pads and cells partitioning addressing 3D-vias reduction and its impact on the 3D circuit design. The approach presents two distinct strategies: the first one is based on circuit structure analyses and the second one reducing the number of connections between non-adjacent tiers. The strategies outperformed a state-of-the-art hypergraph partitioner, hMetis [8] in the number of 3D-vias 19%, 17%, 12% and 16% using two, three, four and five tiers.
Evaluation of a Fault-tolerant Model for Tactic Operations of Mobile Robotic Groups Using Genetic Algorithms
Authors: Pessin Gustavo , Osório Fernando
Published: November 2018

This paper addresses the evaluation of a fault-tolerant model for tactic operations of mobile robotic groups. The coordinated action of the group is planned with Genetic Algorithms (GA) and aims to act on an environmental disaster scenario, simulated as a forest fire. The robotic squad should surround the fire and avoid fire's propagation. Initially, we evaluate several parameters in the GA, seeking to obtain the set of parameters that would accomplish the more efficient evolution. Then, we simulate failures in robots operations in order to evaluate strategies of reorganization. The simulation's results1 showed that with an adequate set of parameters it is possible to get satisfactory strategic positions to coordinate and to reorganize the robotic group in case of robot failures.
Fuzzy Systems for Multicriteria Decision Making
Authors: J. Santos Fábio J. , Camargo Heloisa A.
Published: November 2018

One of the techniques used to support decisions in uncertain environments is the Fuzzy TOPSIS method. However, from crisp data, this method considers only one fuzzy set in their analysis, besides being a strictly mathematical optimization technique. This article proposes extensions to the original Fuzzy TOPSIS, exploring two distinct versions: to increase the method with the necessary resources for the mathematics process to consider the membership values of the input data in more than one fuzzy set and to aggregate to method the empiric knowledge of an expert represented through fuzzy rules. In such case, the method, named by Fuzzy F-TOPSIS (Fuzzy Flexible TOPSIS), is proposed with the objective of improving the Fuzzy TOPSIS ability to deal with uncertainty through the combination of the mathematical process involved in the original Fuzzy TOPSIS with the expert empirical knowledge. A case study is presented to validate the proposal.
Hybrid Rugosity Mesostructures (HRMs) for fast and accurate rendering of fine haptic detail
Authors: Theoktisto Víctor , Fairén Marta , Navazo Isabel
Published: November 2018

Thehapticrenderingofsurfacemesostructure(finerelieffeatures)indensetrianglemeshesrequires special structures, equipment, and high sampling rates for detailed perception of rugged models. Low cost approaches render haptic texture at the expense of fidelity of perception. We propose a faster method for sur- face haptic rendering using image-based Hybrid Rugosity Mesostructures (HRMs), paired maps with per-face heightfield displacements and normal maps, which are layered on top of a much decimated mesh, effectively adding greater surface detail than actually present in the geometry. The haptic probe’s force response algorithm is modulated using the blended HRM coat to render dense surface features at much lower costs. The proposed method solves typical problems at edge crossings, concave foldings and texture transitions. To prove the well- ness of the approach, a usability testbed framework was built to measure and compare experimental results of haptic rendering approaches in a common set of specially devised meshes, HRMs, and performance tests. Trial results of user testing evaluations show the goodness of the proposed HRM technique, rendering accurate 3D surface detail at high sampling rates, deriving useful modeling and perception thresholds for this technique.
A REVIEW OF CLINICAL STUDIES OF ANTICANCER ACTIVITY OF ARTEMISININ DERIVATIVE
Authors: Konovalov D. A. , Khamilonov A. A. , Shevchuk O. M. , Logvinenko L. A.
Published: November 2018

Artemisinin is a sesquiterpene lactone isolated from the aerial part of sweet wormwood (Artemisia annua L.) in the 1970s. Based on its derivatives, the most effective medicines for the treatment of malaria have been created and are widely used. Over the past two decades, numerous in vitro and in vivo studies have been performed. They have shown the anticancer activity of these drugs in relation to certain cancer cell lines.The aimof the study is the review the scientific information on the clinical cases and the results of clinical trials carried out using drugs based on artemisinin derivatives. Material and methods.The study was conducted with the use of information search (PubMed, ScholarGoogle,) and library databases (Cochrane, eLibrary, Cyberleninca), as well as ResearchGate application for semantic search.Results and discussion. It has been established that the largest number of known clinical cases and completed clinical studies is associated with the study of the anticancer activity of one of the artemisinin derivatives - artesunate. The data obtained by various research groups do not yet allow us to speak of a pronounced activity of the latter. However, the facts of prolonging the life of patients, improving its quality, increasing control over the disease have been established.Conclusion. The published data of clinical cases and clinical studies performed for the period from 2001 to 2016, instill restrained optimism about the prospect of using drugs based on some artemisinin derivatives in oncology.
BIOLOGICAL ACTIVITY OF THE COMPONENTS OF ROYAL JELLY AND BEE VENOM
Authors: Mardanly S. G. , Pomazanov V. V. , Kiseleva V. A. , Neskorodov Ya. B.
Published: November 2018

Both bee products themselves and their combinations are widely represented in the domestic pharmaceutical market, however, modern experimental studies of the biological activity of these compounds are few, and in many of the existing publications the authors describe an extremely wide and controversial range of therapeutic effects.The aimof the study is to analyze the experimental works on the study of biological activity of bee products.Materials and methods.The study was conducted using search and information (eLibrary, PubMed, CyberLeninka, ResearchGate) and library databases (Russian State Library, Central Scientific Agricultural Library). In the designated databases, publications were searched by such terms as “biological activity”, “royal jelly”, etc. The depth of the search was not limited.Results and discussion.The analysis of the published works shows that such substances as bee venom and royal jelly have experimentally confirmed their biological activity. In both cases, the active substances have been described and a review of their detected biological activity has been carried out.Conclusion. The authors suggest that when developing the method of laboratory synthesis of decene acids, it can be possible to carry out their large-scale preclinical research, which may become the basis for the creation of a drug with a selective effect.
MODERN ONCO DRUG FOR INTERNAL USE
Authors: Orlova O. L. , Nikolaeva L. L. , Korol L. A. , Dmitrieva M. V. , Polozkova A. P. , Lantsova A. V. , Gulyakin I. D. , Oborotova N. A.
Published: November 2018

Despite the development of biotherapy, chemotherapy remains one of the main methods of treatment of cancer patients. Currently, there are more than 100 anticancer drug substances, however, every year new drugs enter clinical practice and various therapeutic regimens are tested, expanding the possibilities of therapy and improving the results of treatment. Therefore, the adequate use of modern chemotherapy requires constant updating of information about anticancer drugs and methods of their use. Oral administration of drugs is the most natural and convenient way to introduce drugs into the human body. There are about 75% of orally administered drugs that have the ability to be absorbed in the gastrointestinal tract within 1−3 hours after administration. Oral dosage forms (DF) are most common due to the relative simplicity of their production, convenience of use, accuracy of dosing and high stability. Therefore, pharmaceutical companies often reproduce generics in the form of tablets and capsules for oral administration. However, most active pharmaceutical ingredient (API) are destroyed by the action of the gastrointestinal tract environment, which makes it impossible to use the oral administration. This review of the literature describes the main groups of anticancer drugs that are effective when taken orally.The aimof the study is to compile the information on the main groups of anticancer drugs used internally.Materials and methods.The object of the study was well-known anticancer drugs approved for oral administration. The study was conducted using search information and library databases (eLibrary, PubMed, CyberLeninka, ResearchGate), as well as State Register of Medicinal Remedies.Results and discussion.Analyzing the arsenal of cytotoxic drugs, it should be noted that antitumor substances are characterized by high chemical lability they are photosensitive, heat-labile, hygroscopic and hydrolytically unstable. These properties complicate both obtaining reproducible therapeutic effect when taken orally and technological inprocesses. In addition, anticancer drugs have mutagenic, teratogenic, sensitizing and allergenic effects.Conclusion.Lack of sufficient selectivity of the antitumor effect of cytotoxic drugs and a small breadth of pharmacological action require the use of DF, ensuring control of drug delivery to the body, including dosage accuracy and standard bioavailability. DF plays a very important role in the delivery of drugs to the lesion site. Capsules and coated tablets are necessarily created to avoid high toxicity of anticancer drugs and local tissue reactions when taken orally.
MICROMORPHOLOGICAL ANALYSIS OF THE AERIAN ORGANES OF MARRUBIUM ALYSSON L. FROM FLORA OF TUNISIA
Authors: Serebryanaya F. K. , Zayer G.
Published: November 2018

The micromorphological investigations ofMarrubium alysson L.growing on the territory of the Tunisian Republic have been conducted.The aimof the study was to conduct comparative ecological and morphological researches ofMarrubium alyssonaerian parts, to study an anatomical structure of caulifoliary system elements including stems, petioles, leaf margins a structure of the epidermis.Materials and methods.As an object of the research, dried-up herb and herbarium specimens ofMarrubium alysson L., growing on the territory of the Tunisian Republic, were used. The micromorphological investigations were conducted by morphological and histochemical methods.Results and discussion.Comparative ecological and morphological researches have been conducted. The anatomic structure of the elements of the caulifoliary system including stems, petioles, leaf margins has been studied. The anatomic structure of the epidermis has been studied, too. The diacytic type of the stomatal apparatus, numerous branched trichomes with multicellular basis, located both on top and lower leaf parts have been found out. The conducted researches are a fragment of complex researches of perspective raw plants of Tunisian flora.Conclusion. Comparative eсological and micromorphological researches have been conducted, the anatomic structure of the stems, petioles, leaf margins, and also the epidermis structure of top and lower leaf parts has been also carried out. The diacytic type of the stomatal apparatus, trichomes with multicellular basis located both on top and lower leaf parts have been found out. The collenchyme is located in the subepidermal zone of a stem, petioles and in the zone of the central vein of a limb. The revealed signs can be included into product specification files on herbal raw materials
INTENSIFICATION OF PRODUCTION PROCESS OF THICK EXTRACT OF MILK THISTLE FRUITS BY ULTRASONIC PROCESSING OF RAW MATERIALS
Authors: Zhilyakova E. T. , Tsvetkova Z. E. , Pisarev D. I. , Boyko N. N. , Tymoshenko E. Yu.
Published: November 2018

The aim. This article is devoted to the intensification of the production process of a thick extract of milk thistle fruits using ultrasonic processing of raw materials.Materials and methods.As an object of the study, the crushed milk thistle fruitss from Penza “Biokor” company were used. As the extractant, an aqueous solution of ethanol 70% vol. was used. For ultrasonic processing of plant materials and extractant, the installation “Bandelin SONOPULS HD 3200” was used, the ultrasound frequency was 20 kHz, the radiator power was 280 W, and the temperature was 25°С. The concentration of the extract was performed using a rotary evaporator RV-10 at the temperature of 60°C and a vacuum of 600–650 Mmhg to a residual moisture content of 25%. Qualitative and quantitative analysis of the thick extract was carried out using spectrophotometry and chromatography. Quantitative analysis of the amount of flavolignans was performed on an SF-56 spectrophotometer. The separation of the flavolignan complex and the quantification of silibinin was performed on a liquid chromatograph “Agilent Technologies 1200 Infinity”.Results and discussion. During the study it was found out, that processing of the crushed milk thistle fruits by ultrasound at the soaking stage almost doubles the output of the flavoligan complex from medicinal plant materials. The maximum amount of flavolignans is extracted when the fruits of milk thistle and extractant are processed with ultrasound at the frequency of 20 kHz for 5 minutes. Thus the obtained thick extract of milk thistle fruits in the component composition contains both the target flavolignan complex (87.39%, silibinin – 24.36%), providing the hepatoprotective effect, and flavonoids – chlorogenic acid (1.69%) and dihydroquercetin (10.92%) exhibiting antioxidant activity. It was established that, according to the qualitative composition of flavolignans, the obtained thick extract corresponds to preparations based on milk thistle. Thus, for the first time, the method was proposed for obtaining a thick extract of milk thistle fruits using ultrasonic processing of raw materials and extractant at the soaking stage. The obtained thick extract is proposed to be used as an active pharmaceutical substance for the production of granules based on methionine and milk thistle flavolignans.Conclusion. The results of the experiments allow us to recommend obtaining a thick extract of the milk thistle fruits, using the stage of ultrasonic processing of raw materials and extractant for 5 minutes at the ultrasound frequency of 20 kHz.
METHOD FOR DETERMINING THE UPPER LIMIT OF CEREBRAL AUTOREGULATION IN RATS
Authors: Voronkov A. V. , Lysenko A. S.
Published: November 2018

The main objective of the phenomenon of cerebral autoregulation is to maintain a constant cerebral blood flow rate with changes in systemic arterial pressure in the range of 50 mmH up to 150 Mmhg. To study this phenomenon, there are two approaches: dynamic and static. The dynamic approach is known to the study autoregulation, can indirectly characterize this phenomenon with the help of calculated indicators, and the described static methods can characterize only the lower limit of autoregulation of cerebral blood flow.The aimof the study was to develop a method for determining the value of pressure at the “breakdown” point of the upper limit of cerebral hemodynamics autoregulation.Materials and methods. The experiment was carried out on male rats of the Wistar line weighing 200–250 g, kept in standard vivarium conditions. The essence of the method of establishing the upper “breakdown” point of the autoregulatory mechanisms of cerebral circulation is pumping blood from the femoral artery to both carotid arteries by means of a peristaltic pump, while controlling the pressure and cerebral blood flow velocity. In order to avoid blood loss as a result of blood flow redistribution, external carotid arteries were ligated. The pressure was measured by the direct method. Since the pressure is created by the resistance of the cerebral vessels, it can be measured at the entrance by specially modeled carotid catheters. Cerebral blood flow velocity was measured by an ultrasound doppler scanner using MDK-Minimax Doppler v .2.1 program. To establish the possibility of using this method in the study of the influence of substances on the autoregulation of cerebral circulation, the effect of nicergoline on this phenomenon was studied. The drug was administered as a suspension intragastrally to rats 1 hour before metering.The results and discussionof the experiment showed that in intact rats the “breakdown” point of the upper limit of autoregulation was recorded at 165.0 ± 3.4 Mmhg (M ± m). Statistical processing of the obtained data indicates the normal distribution of the sample and the validity of the developed method. The introduction of nicergoline led to the increase in pressure at which there was a “breakdown” of the autoregulation mechanisms to 181.7 ± 4.7 Mmhg, which was significantly higher than the values of the intact group.Conclusion. As a result of the experiment on male rats, a valid method was developed for determining the blood pressure value at the highest point of “breakdown” of cerebral hemodynamics autoregulation and it was established that nicergoline shifts the functioning limit of the autoregulation phenomenon to higher values.
Workshop Session
Authors: UPH FK
Published: November 2018

Abstracts of the Dies Natalis Fakultas Kedokteran Universitas Pelita Harapan XVII 2018 Workshop Session
Poster Session
Authors: UPH FK
Published: November 2018

Abstracts of the Dies Natalis Fakultas Kedokteran Universitas Pelita Harapan XVII 2018 Poster Session
List of Authors
Authors: UPH FK
Published: November 2018

Abstracts of Dies Natalis Faculty of Medicine Universitas Pelita Harapan XVII 2018 - List of Authors
Scientific Programme
Authors: UPH FK
Published: November 2018

Scientific Programme of the Dies Natalis Faculty of Medicine Universitas Pelita Harapan XVII 2018
Opredelitev gozdnih območij s poudarjeno zaščitno funkcijo
Authors: Guček Matjaž , Bončina Andrej
Published: November 2018

We created determination procedure for forests with direct protection function according to the type of natural hazards and damage potential. The model was tested in two forest management units (Jezersko and Tržič) for two natural hazards % rockfall and avalanches. We determined areas with direct protection function on the basis of: 1) modelling risk areas of rockfall and avalanches, 2) data on buildings, settlements and infrastructure, and 3) area of forest. Numerous data were processed with different software, but mainly with MapInfo 10.5, ArcGIS 10.0 and Conefall - 3D friction model. We delineated direct protection function on the area of 625 ha, mainly due to protection against rockfall (44 %), avalanches (27 %), while 29 % of the area was determined due to rockfall and avalanches together. The degree of risk in the areas with direct protection function is mainly high (65 %). Our results showed that official data on areas with direct protection function were underestimated.
Observed Leverage and Financial Performance of Listed Firms in Kenya
Authors: Maina Leonard Kiragu , Olweny Tobias , Wanjau Kenneth
Published: November 2018

Capital structure management is one of the most crucial corporate financial management functions in a firm since appropriate debt policy is reported to maximize the value of a firm. Kenya is ranked second in Africa after South Africa in regards to financial deepness. This means that the cost of debt should not have adverse effect financial performance. This observation raises fundamental question: does debt financing leads to poor financial performance in Kenya? This research sought to investigate the role of observed leverage on financial performance of listed non- financial firms in Kenya. The study tested capital structure theories and therefore adopted a positivists approach, guided by causal research design. The study population was 35 non-financial sub-sector firms out of the 65 firms listed at the NSE, Kenya. 18 firms were excluded in this study since they belong to banking and insurance sub-sectors, which have a highly regulated capital structure. Secondary data collection sheet was used to collect data for each of the variables from audited financial statements of the listed firms for a 10-year period (2006-2015). Panel regression analysis revealed that observed leverage measured by (LDR) had a significant positive coefficient with performance metrics. However, the leverage measure using TDR showed a negative and significant role on performance metrics. This study recommends that for listed firms to improve their financial performance, they should use more long-term debts than short-term debts.
Indonesian Logistics Infrastructure: The Performance and Fiscal Support
Authors: Setiawan Sigit
Published: November 2018

In the globalization and ASEAN Economic Community era, the competitiveness of Indonesian industries to sell goods and services is facing more severe challenges. It is partly due to the low performance of Indonesian logistics sector, and one of the contributing factors to the unsatisfactory logistics is poor logistics infrastructure. In this regard, this paper has several research objectives. The first is to analyze the performance of Indonesia logistics infrastructure in the past decade. The second is to analyze Indonesian logistics infrastructure development with its relevant fiscal policy support and evaluate its short-term progress. The research method adopted in this study is descriptive analytical method. In comparison with other countries, especially ASEAN region, the performance of Indonesian logistics infrastructure over the past decade tends to be steadily incompetitive, below the average of ASEAN countries. It is found to be one of the prime determinants of the high logistics costs in Indonesia. The government serious attention and the consistency of its policy towards improving logistics infrastructure during the 2014-2019 period has been partially seen, but the program sustainability is required in subsequent periods. In the short term, a temporary evaluation until 2017 of the sea toll program integrated with the construction of logistics infrastructure shows a positive impact. The positive impact is indicated from the decreasing prices of basic necessities in the eastern region of Indonesia by 20%-40%, and the economic revival of Eastern Indonesia region due to currently cheaper transportation costs.
Operations Management and Performance of Manufacturing Small and Medium Enterprises in Kenya
Authors: Mkala Mwamisha D , Wanjau Kenneth L , Kyalo Teresia N
Published: November 2018

Manufacturing small and medium enterprises (SMEs) are the breeding ground for human capital competencies, creativity and innovation, which are important inputs for manufacturing competitiveness. In Kenya, manufacturing SMEs contribute 14% of gross domestic product (GDP), and train and employ 30% of the workforce. However, their growth and competitiveness are undermined by challenges in the firms’ operations management. Consequently, the firms struggle to survive as competitive enterprises, both domestically and globally. The purpose of this study was to establish how entrepreneurial orientation (EO) enhances the relationship between operations management and firm performance. Quantitative primary data were collected from managers of 83 firms registered by the Kenya Association of Manufacturers in the food and beverage sub-sector using a self-administered questionnaire. Structural equation modelling was used to analyse the data for relationships between the study variables. The study found a positive relationship between operations management and EO, and between EO and firm performance. The study also found that EO is a mediator of the relationship between operations management and performance of manufacturing SMEs in Kenya. The study recommends that for manufacturing SMEs to effectively deploy operations management competencies and gain global competitiveness, they must engage EO as a strategy to foment organisational experimentation and exploration and commercialize the resultant innovations. At the macroeconomic level, the government should support manufacturing SMEs through enactment and promotion of policies that enable operations managers to exploit their firm’s EO stock.
The Influence of Community Behaviour on the Quality of Tourism Services at Toba Lake North Sumatera
Authors: Revida Erika , Siahaan Asima Yanti , Purba Sukarman
Published: November 2018

This research aim as analyzing the influence of community behaviour on the quality of tourism services at Toba Lake North Sumatera. The method of research used mixed between quantitative and the qualitative research. Research sample were taken from 120 head of family at Toba Lake North Sumatera. The technique of data collection of research used documentation study, questionnaires, interviews and observations. The technique data analysis used Simple and Multiple Regression Analysis. The research results showed that there was positive and significant influence between community behavior on the quality of tourism services at Toba Lake North Sumatera. The recommendations of the research stated that it was important to enhance the quality of tourism services by enhancing knowledge, attitude and action about the quality of tourism services so that the quality of tourism services will be increased, and it need to establish tourism school at the Toba Lake North Sumatera
Corporate Social Irresponsibility and Purchase Intention
Authors: Kwamboka Juniter , Obonyo Duke D.
Published: November 2018

An important objective of business research is to understand how organizational practices can influence consumer attitude and behaviors in order to help achieve organizational goals via consumer purchase intention. It was proposed and found in this study that consumers’ perceptions of certain Corporate Social Irresponsible (CSI) practices serves as antecedents of consumer purchase intention (PI) via corporate reputation (CR) and consumer attitude (CA). On the one hand, this finding may help understand the “black box” between CSI practices and PI. On the other hand, while CR refers to customers’ evaluations of the reputation of the organization and CSI represent a significant channel the organization uses to channel its irresponsible behavior to the community, CR and CA literatures have not comprehensively examined the effect of CSI practices on consumers CA and CR beliefs.  The findings in the hierarchical regression from a sample of 455 consumers of products in a large corporate organization in Kenya as a study documenting a negative association between CSI practices and CR and CA with PI suggests that consumers draw inferences from the CSI-related treatment they receive in assessing the supportiveness of the organization. By implementing CSI practices that demonstrate the organization does not care about the community and values their contribution, organizations are likely to be perceived as engaging in a high level of irresponsible behaviour. The results of this study add to our knowledge about the antecedents of CR and CA. Moreover, this study bridges the gap in the literature, by combining CSI, CR, CA and PI.
Prospects and Competitiveness in Creative Economy: Evidence from Indonesia
Authors: Setiawan Sigit
Published: November 2018

A growing number of unimaginable cross-border start-up businesses have emerged in the ASEAN and global trade map, along with the development of communication and information technology that negates national borders.  The new sector-referred to as creative economy - requires and utilizes high specific knowledge, skills and creativity. With literature review and descriptive analysis method, this study aims to: firstly, analyze the prospects for Indonesian creative economic sector in the ASEAN market; secondly, analyze the competitiveness of Indonesia's creative economic sector in ASEAN and the world levels. By making comparison of the data in two periods (2002-2006 and 2014-2015 periods), it can be concluded that the average contribution of creative economy to Indonesian economy continues to increase. The increase goes to the added value, the sectoral contribution to GDP, the provision of employment, and the sectoral absorption of national labor. The prospect of Indonesian creative economy in the ASEAN market lies in the growth of potential customers from the middle class. The number of Indonesian middle class will continue to increase. By adopting and analyzing the output of the Global Creativity Index model, it can be concluded that the competitiveness of Indonesian creative economy in ASEAN and the world is still weak. The weak competitiveness is due to low technology index and talent index. However, based on the findings from previous studies in several regions in Indonesia, it appears that Indonesian people have great potential creativity to develop
Urdesa-Guayaquil: Transformación morfológica, tipológica, social y funcional desde una perspectiva de seguridad
Authors: Lozano Leiva Andrea Natalia
Published: November 2018

La ciudad de Guayaquil ha tenido constantes transformaciones a lo largo de los años. De la ciudad española "nómada" a la actual metrópoli, Guayaquil ha sabido sobreponerse a incendios, pestes, inundaciones, inseguridad y malas administraciones. Se toma como estudio de caso Urdesa, ciudadela de mediados del siglo XX, la cual ha evolucionado de zona residencial a zona de usos múltiples (residencial y comercial) a lo largo de su historia. Se estudiarán las intervenciones por parte del Municipio de la ciudad y cómo estas han afectado a la ciudadela. En la primera parte de la investigación se presentan las diferentes etapas históricas de la ciudad, así como los acontecimientos más relevantes que la han llevado a su actual evolución morfológica y tipológica. En el segundo apartado, Urdesa, se localizan las ordenanzas municipales, se las grafica y analiza en su situación actual. Se concluye sobre cómo la evolución ha incidido sobre los patrones de desplazamiento de la población de Guayaquil y cómo estos han inducido en la aceptación de nuevos patrones de sociedad.