bluuebunny/crossref_metadata_2025 huggingface dataset:
Pharmacokinetic and Pharmacodynamics Study of Multiple Oral Doses of Vildagliptin Sustained Release 100 Mg Tablets under the Fed State in Healthy Volunteers
Authors: Doshi Chetan , Sridhar S B , Birla Ashish , Prasad Ashish , Kadam Pramod , Warrier Sona
Published: September 2023

This study evaluated the pharmacokinetic and pharmacodynamic profile of the vildagliptin 100 mg sustained release (SR) administered once daily compared to vildagliptin 50 mg immediate release (IR) administered twice daily in healthy, adult human subjects under fed conditions.

This was a randomized, balanced, open-label, two-treatment, two-period, two-sequence, crossover multiple oral dose study in healthy adult subjects under fed conditions. The subjects were randomized to receive either a test product, i.e., vildagliptin SR 100 mg once daily, or a reference product, i.e., vildagliptin 50 mg twice daily. The duration of the study was 25 days. The primary pharmacokinetic parameter evaluated was the area under the concentration-time curve for one dosing interval at steady-state (AUC0-τ, ss). Bioequivalence was determined by assessing whether the 90% confidence intervals (CIs) for the geometric mean ratio of test to reference drug fell within predefined margins of 80% −125% for AUC0-τ, ss. The pharmacodynamics parameters evaluated were percent dipeptidyl-peptidase-4 (DPP-4) inhibition and weighted average percent DPP-4 inhibition. 

Forty healthy adult males completed the study. There was no significant difference between the pharmacokinetic and pharmacodynamic profiles in reference and test products. The mean ± standard deviation (SD) values of AUC0-τ, ss for test and reference product was 2689.06 ± 835.47 2875.57 ± 703.85 ng. hr/mL, respectively. The 90% CIs of geometric least-square means of test/reference ratio for AUC0-τ, ss with vildagliptin SR 100 mg tablet was 86.32-97.26% within the bioequivalence acceptance range. The test and reference product showed over 90% inhibition of DPP-4 activity with multiple doses. The weighted average percent of DPP-4 inhibition (0-24 hrs) was 92.66% with the test product and 93.26% with the reference product. Both products were well tolerated during the entire study period. No serious or life-threatening adverse events (AEs) were reported during the study.

The two formulations of vildagliptin, i.e., vildagliptin SR 100 mg once daily and vildagliptin 50 mg twice daily, demonstrated similar pharmacokinetic and pharmacodynamic profiles under fed conditions in healthy adult males. Both formulations were bioequivalent and well tolerated.
Pelatihan Merangkai Bunga dan Bahasa Inggris untuk Anak Anak Panti Asuhan Ananda Seva Dharma
Authors: Koeswiryono Dika Pranadwipa , Sulasmini Ni Made Ayu , Antara Ida Bagus Ketut Soma
Published: September 2023

Pengabdian ini bertujuan untuk memberikan pelatihan merangkai bunga dan bahasa Inggris yang diselenggarakan oleh IPB Internasional di Panti Asuhan Ananda Seva Dharma. Pelatihan merangkai bunga bertujuan untuk mengembangkan keterampilan seni dan kreativitas anak-anak, sementara pelatihan bahasa Inggris bertujuan untuk meningkatkan kemampuan berkomunikasi mereka. Metode pengajaran yang digunakan meliputi sesi teori, demonstrasi, dan praktik langsung. Selain itu, diberikan pula kegiatan kelompok untuk meningkatkan kerjasama dan komunikasi antar peserta. Pelatihan ini memberikan manfaat jangka panjang bagi anak-anak di Panti Asuhan Ananda Seva Dharma. Keterampilan merangkai bunga dapat menjadi sumber penghasilan di masa depan, sementara kemampuan bahasa Inggris dapat membuka peluang pendidikan dan karir yang lebih baik. Oleh karena itu, program pelatihan yang dilakukan oleh IPB Internasional memiliki nilai yang signifikan dalam memajukan potensi anak-anak panti asuhan dan memberikan mereka kesempatan untuk meraih masa depan yang lebih baik.
Green Movement di Ekowisata Subak Sembung Desa Peguyangan
Authors: Widana I Ketut Arta , Darma I Gusti Ketut Indra Pranata , Nuriawan I Nengah Alit , Ariputra I Putu Suyasa , Risadi Md Yudyantara
Published: September 2023

Green Movement telah menjadi landasan penting dalam upaya global untuk melestarikan lingkungan dan mendorong praktik berkelanjutan. Dalam konteks ekowisata, Green Movement berperan krusial dalam mengajak masyarakat untuk terlibat aktif dalam pelestarian alam dan budaya melalui praktik yang ramah lingkungan. Artikel ini mengkaji implementasi Green Movement dalam ekowisata Subak Sembung, sebuah destinasi yang menggabungkan keanekaragaman hayati, keindahan alam, dan warisan budaya di Desa Peguyangan, Denpasar. Melalui pendekatan kualitatif, penelitian ini mendokumentasikan upaya konkret yang telah diambil untuk mengedukasi dan melibatkan masyarakat dalam praktik berkelanjutan. Dengan menganalisis partisipasi masyarakat, strategi pendidikan, serta dampak yang terlihat, artikel ini memberikan wawasan tentang bagaimana Green Movement menjadi pendorong utama di balik pengembangan ekowisata Subak Sembung. Hasil penelitian menunjukkan bahwa melalui pendidikan dan kampanye kesadaran, masyarakat setempat semakin memahami pentingnya pelestarian lingkungan dan keterlibatan dalam upaya ini. Pengalaman edukatif, seperti tur lingkungan dan kegiatan praktis, telah memberikan kesempatan bagi pengunjung dan masyarakat untuk belajar secara langsung tentang manfaat praktik berkelanjutan. Partisipasi aktif dalam kegiatan pelestarian, seperti penanaman pohon dan pengelolaan sampah, mencerminkan adopsi nilai-nilai Green Movement dalam kehidupan sehari-hari.
 
The Green Movement has become an important cornerstone of global efforts to make the environment a reality and promote sustainable practices. In the context of ecotourism, the Green Movement plays a crucial role in inviting the community to be actively involved in preserving nature and culture through environmentally friendly practices. This article reviews the implementation of the Green Movement in Subak Sembung ecotourism, a destination that combines biodiversity, natural beauty and cultural heritage in Peguyangan Village, Denpasar. Through a qualitative approach, this study documents the concrete efforts that have been taken to educate and engage communities in sustainable practices. By analyzing community participation, education strategies, and visible impacts, this article provides insight into how the Green Movement is the main driver behind the development of ecotourism in Subak Sembung.The results of the research show that through socialization and awareness campaigns, local communities are increasingly understanding the importance of environmental preservation and are involved in these efforts. Educational experiences, such as environmental tours and hands-on activities, have provided opportunities for visitors and the public to learn first-hand about the benefits of sustainable practices. Active participation in conservation activities, such as tree hiding and waste management, reflects the adoption of Green Movement values in everyday life.
Pelatihan Teknik Dongeng Sebagai Metode Pengajaran Orang Tua Kepada Anak di TK RA Mentari
Authors: Fauzia Nur , Fahri Fahri , Purwati Oikurema , Kuswardani Rahayu , Darma Fithriyah Inda Nur Abida Diana Budi
Published: September 2023

Karya tulis ilmiah ini bertujuan untuk mengevaluasi efektivitas pelatihan teknik dongeng sebagai metode pengajaran orang tua kepada anak di TK RA Mentari. Metode yang digunakan adalah pendekatan campuran (mixed-methods) dengan menggabungkan data kualitatif dan kuantitatif. Populasi dalam kegiatan ini adalah seluruh orang tua dari anak-anak yang bersekolah di TK RA Mentari, dengan sampel penelitian dipilih secara purposif. Pelatihan teknik dongeng dilaksanakan untuk meningkatkan keterampilan dan pengetahuan orang tua dalam menggunakan dongeng sebagai alat pengajaran kepada anak-anak. Hasil analisis data menunjukkan adanya peningkatan yang signifikan pada keterampilan orang tua setelah mengikuti pelatihan. Orang tua mampu mengintegrasikan teknik dongeng dengan kreativitas dan efektivitas dalam aktivitas pembelajaran bersama anak di rumah dan di sekolah. Dampak implementasi teknik dongeng oleh orang tua pada perkembangan anak juga diamati melalui observasi perilaku anak di kelas dan wawancara dengan guru atau pengasuh. Hasilnya menunjukkan bahwa anak-anak yang memiliki orang tua yang aktif dalam menggunakan teknik dongeng menunjukkan peningkatan dalam perkembangan bahasa, moral, dan imajinasi. Pelatihan teknik dongeng sebagai metode pengajaran orang tua kepada anak di TK RA Mentari memberikan dampak positif dan signifikan dalam pendidikan anak usia dini.
 
This scientific paper aims to evaluate the effectiveness of storytelling technique training as a method of teaching for parents to their children at TK RA Mentari (Mentari Kindergarten). The method used is a mixed-methods approach, combining qualitative and quantitative data. The population of this study consists of all parents of children attending TK RA Mentari, with the research sample chosen purposively. The storytelling technique training was conducted to enhance the skills and knowledge of parents in using storytelling as a teaching tool for their children. The results of data analysis indicate a significant improvement in the skills of parents after attending the training. Parents were able to integrate storytelling techniques creatively and effectively in learning activities with their children at home and at school. The impact of implementing storytelling techniques by parents on children's development was also observed through the observation of children's behavior in the classroom and interviews with teachers or caregivers. The results showed that children with parents actively using storytelling techniques demonstrated improvements in language, moral, and imaginative development. Storytelling technique training as a method of teaching for parents at TK RA Mentari provides a positive and significant impact on early childhood education.
Modeling the risk premium in the Russian stock market considering the asymmetry effect
Authors:   HSE University, Moscow, Russian Federation, Trifonov Juri
Published: September 2023

The study examines the risk premium modeling for three major Russian stock market indices. The key feature is accounting for the asymmetry effect in the risk premium via the asymmetric GARCH‐M model. The empirical analysis provided evidence favoring a significant leverage effect in the risk premium in the Russian market. However, the effect sign is contrary to the hypothesis and the empirical evidence in the American market. These findings are probably explained by the violation of the efficient market hypothesis and the presence of a high proportion of irrational investors in the Russian stock market.
“Dostoevsky Gave Us a Taste of What It Is Like to Come Out of Isolation.” Interview with Tatiana Kasatkina
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Podosokorsky Nikolay N. , Corbella Caterina ,   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Magaril-Il'iaeva Tatiana G. ,   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences
Published: September 2023

The material presents an interview with Tatiana A. Kasatkina, Doctor of Philological Sciences, Director of research at IWL RAS, Head of the Research Centre “Dostoevsky and World Culture” IWL RAS, Head of the Research Committee for Dostoyevsky’s Artistic Heritage within the Academic Council for the History of World Culture RAS. The talk is devoted to the problems of human sciences and culture in the modern world and the challenges facing humanity.
About Tatiana Kasatkina, From-Subject-To-Subject Method, and “Realism in the Highest Sense”
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Gacheva Anastasia G.
Published: September 2023

The article, dedicated to the anniversary of the prominent Russian literary scholar, philologist, philosopher, and educator, Tatiana A. Kasatkina, represents an overview on the sidelines of her theoretical and historical-literary works. Since the 1990s, Tatiana Kasatkina has engaged in a dispute with “positivism” in philology, defending the rights of literary scholars to religious thinking and demonstrating its significance for the humanities. The controversy over “religious philology” sparked by her book was resolved in practice: Tatiana Kasatkina’s creative work, dedicated to the status of words in Dostoevsky’s artistic world, the structure of the image, the author’s position, problems of reading, and perceiving his works, demonstrated the productivity of her "from-subject-to-subject" method of research and understanding of the text. Tatiana Kasatkina showed that Dostoevsky’s artistic method, which he defined as “realism in the highest sense,” is based on a religious worldview and implies the inseparability of the image and the Archetype.
Bibliography of Tatiana Kasatkina
Authors: Podosokorsky Nikolay N.
Published: September 2023

This contribution presents a bibliography of academic, critical, and literary works by Tatiana A. Kasatkina, Doctor of Philological Sciences, Director of Research at IWL RAS, Head of the Research Centre “Dostoevsky and World Culture” IWL RAS, Head of the Research Committee for Dostoevsky’s Artistic Heritage within the Academic Council for the History of World Culture RAS.
“And Here You Have a Bug Crawling...” (Some Observations On “Dostoevsky’s Entomology”)
Authors:   Fyodor Dostoevsky Museum, Tikhomirov Boris N.
Published: September 2023

The article is devoted to an overview of entomological imagery (spiders, ants, cockroaches, flies, etc.) in Dostoevsky’s literary and journalistic texts. The author focuses on the difference between the autological and metalogical (comparison, metaphor, symbol) use of images of insects and traces their frequency and artistic specifics in different periods of the writer’s work. The sharp increase in the number of entomological images since 1860s is related to the formation of a new artistic anthropology in Dostoevsky based on his convict experience. Special attention is paid in the article to the entomological image of bugs, which has not attracted large attention from the researchers of the writer’s artistic world.
In Search of Wool(s)
Authors: Bilge Merve Aktaş
Published: September 2023

This project explores the potential futures of wool. Despite being a significant craft material, wool has become a byproduct of sheep and lamb industry in most areas. In many places, fleece and wool use is in decline. Consistent with the global trend, wool production has also declined in the US since the 1940s . When wool is used in textile industries, merino wool from Australia and New Zealand often dominates the scene, thus contributing to the decline in local wool. As a result, large amounts of wool, a material with great qualities, becomes unwanted product and is discarded as a waste.

A project about and with wool can bring new possibilities for the future of wool for producers and craftspeople. In this project, I will research wool's current situation around Asheville by visiting some farms and discussing with craftspeople. This research will draw on the current situation and start contextualizing how wool might be studied.
Mapping the Path to a Net-Zero Chemicals Industry by Long-Term Planning with Changes in Technologies and Climate
Authors: Thakker Vyom , Bakshi Bhavik
Published: September 2023

Many corporations and nations have pledged to reach net-zero emissions
within a few decades. Meeting such targets for greenhouse gases,
plastics, etc. requires systematic methods to guide investment in
technologies and value-chain alternatives, and develop roadmaps. The
proposed framework is a multi-period planning model to guide optimal
reforms in cradle-to-cradle life-cycle networks across the time horizon.
It aims to meet environmental targets while minimizing the total
annualized marginal cost of natural resources and the investment cost
associated with adoption of novel technologies. This considers the
evolution of technology readiness levels as S-curves or continuous time
Markov-chains. Integrated Assessment models account for climate change,
decarbonization due to energy mix changes, and carbon taxes. Multiple
climate change scenarios and shared socioeconomic pathways are used to
model the future. In addition to providing roadmaps, the outputs can
also be used to identify technologies that will be robust to future
scenarios.
Spatial structure drives compositional convergence between nutrient environments in microbial communities
Authors: Newbury Arthur , Kuijper Bram , Buckling Angus
Published: September 2023

While abiotic variation is undoubtedly important in shaping the
composition of ecological communities, the extent to which environment
predicts composition varies between communities and habitats. This
raises the question of which features lead to robustness in the face of
environmental change. We identify spatial structure as a major factor in
dampening the effects of abiotic variation. Individual-based models
predict that spatial structure leads to compositional convergence
between environments that impose divergent selection pressures. We then
test these predictions using microbial communities cultured on divergent
carbon sources and which experience different degrees of spatial
structure provided by glass beads. Again, more spatial structure results
in increased community convergence across abiotic environments. Our work
suggest that spatial structure can mitigate against the ecological
consequences of environmental heterogeneity.
The Pharmacokinetics Difference between 10µg and 15µg Daily Vitamin D Doses
Authors: You Tao , Muhamad Nadda , Jenner Joseph , Huang Zhonghui
Published: September 2023

Aim The reference nutrient intake for vitamin D in people aged ≥4 years
is 10 μg/day (400 IU/day) in the UK, but the recommended daily allowance
is 15 μg/day (600 IU/day) for people aged 1-70 years in the US. Here, we
aim to compare the 25-hydroxyvitamin D3 (25(OH)D3) serum concentration
profiles between the two doses. Methods With adult trial data, we
constructed a physiologically based pharmacokinetics (PBPK) model of
serum concentrations of vitamin D3 and 25(OH)D3 using nonlinear mixed
effects (NLME) modelling. We used this model to forecast the mean, 5%
and 95% percentiles for serum 25(OH)D3 concentrations. Results Our
final model uses bodyweight to adjust volume of each compartment and
maximum clearance of 25(OH)D. No other covariate was identified. The
model accurately predicted data from trials of a broad range of dose
regimens. We simulated subjects of the average UK male and female
weights with baseline 25(OH)D < 25 nmol/L. Simulation suggests
circulating 25(OH)D concentrations in >5% of men and women
taking 10 μg/day for a year might fail to reach 50 nmol/L, while those
on 15 μg/day were predicted to attain this threshold. Conclusion The two
doses generate significant difference in serum 25(OH)D3 concentrations.
This needs to be considered for choosing the right dose for the public
health guideline.
Deep Learning driven interpretation of Chang'E4 Lunar Penetrating Radar
Authors: RONCORONI Giacomo , Forte Emanuele , Santin Ilaria , Černok Ana , Rajšić Andrea , Frigeri Alessandro , zhao wenke , Pipan Michele
Published: September 2023

We reprocessed and interpreted Chang’E-4 Lunar Penetrating Radar (LPR)
data collected until 14th February 2023, exploiting a new Deep
Learning-based algorithm to automatically extract reflectors from a
processed radar dataset. The results are in terms of horizon probability
and have been interpreted by integrating signal attribute analysis with
orbital imagery. The approach provides more objective results by
minimizing the subjectivity of data interpretation allowing to link
radar reflectors to their geological context and surface structures. For
the first time, we imaged dipping layers and at least 20 shallow buried
crateriform structures within the regolith using LPR data. We further
recognized four deeper structures similar to craters, locating ejecta
deposits related to a crater rim crossed by the rover path and visible
in satellite image data.
Blocking Hemopexin With Specific Antibodies: A New Strategy for Treating Diabetic Retinopathy
Authors: Bogdanov Patricia , Duarri Anna , Sabater David , Salas Anna , Isla-Magrané Helena , Ramos Hugo , Huerta Jordi , Valeri Marta , García-Arumí José , Simó Rafael , Hernández Cristina
Published: September 2023

Hemopexin (HPX) is overexpressed in the retina of patients with diabetes and induces the breakdown of the blood-retinal barrier in vitro. The aim of this study was to evaluate whether HPX blockade by specific antibodies (aHPX) could avoid vascular leakage in vivo and microvascular angiogenesis in vitro and ex vivo. For this purpose, the effect of intravitreal (IVT) injections of aHPX on vascular leakage was evaluated in db/db mice and rats with streptozotocin-induced diabetes using the Evans Blue method. Retinal neurodegeneration and inflammation were also evaluated. The antiangiogenic effect of aHPX on human retinal endothelial cells (HRECs) was tested by scratch wound healing and tube formation using standardized methods, as well as by choroidal sprouting assays from retinal explants obtained in rats. We found that IVT injection of aHPX significantly reduced vascular leakage, retinal neurodegeneration, and inflammation. In addition, treatment with aHPX significantly reduced HREC migration and tube formation induced by high glucose concentration and suppressed choroidal sprouting even after vascular endothelial growth factor stimulation, with this effect being higher than obtained with bevacizumab. The antipermeability and antiangiogenic effects of IVT injection of aHPX suggest the blockade or inhibition of HPX as a new strategy for the treatment of advanced stages of diabetic retinopathy.

Article Highlights

Hemopexin (HPX) is the best-characterized permeability factor in steroid-sensitive nephrotic syndrome. We have previously reported that HPX is overexpressed in the retina of patients with diabetes and induces the breakdown of the blood-retinal barrier in vitro. Here, we report that intravitreal injection of anti-HPX antibodies significantly reduces vascular leakage, retinal neurodegeneration, and inflammation in diabetic murine models and that the immunoneutralization of HPX exerts a significant antiangiogenic effect in vitro and in retinal explants. The blockade of HPX can be considered as a new therapy for advanced stages of diabetic retinopathy.
Romantic Relationships Among Emerging Adults With and Without Type 1 Diabetes
Authors: Helgeson Vicki S.
Published: September 2023

We compared the romantic relationships of emerging adults with type 1 diabetes to those without type 1 diabetes. We examined whether there were group differences in romantic relationships and relationship quality and whether aspects of romantic relationships were connected to psychological and diabetes health. Emerging adults (mean age 27 years) with (n = 88) and without (n = 99) type 1 diabetes took part in the study. Participants completed an online questionnaire that assessed romantic relationships, psychological health, and diabetes health. Results showed that males with type 1 diabetes were significantly less likely than males without diabetes and either group of females to be involved in a romantic relationship. Among those in a relationship, there were no group differences in relationship quality. For both groups, being in a relationship was associated with less loneliness and greater life satisfaction. Among those in a romantic relationship, the quality of the relationship was more strongly related to psychological outcomes for those with than for those without diabetes. There was modest evidence that relationship quality was linked to better diabetes outcomes. When partner supportive and unsupportive diabetes interactions were examined, there was more evidence that unsupportive interactions were harmful (i.e., related to worse psychological and diabetes outcomes) than there was evidence that supportive interactions were beneficial. These findings underscore the importance of romantic relationships for health among emerging adults in general and suggest that there may be an even greater impact for those with type 1 diabetes.
Protease-Activated Receptor 1 Mediated Damage of Podocytes in Diabetic Nephropathy
Authors: Bohovyk Ruslan , Khedr Sherif , Levchenko Vladislav , Stefanenko Mariia , Semenikhina Marharyta , Kravtsova Olha , Isaeva Elena , M. Geurts Aron , A. Klemens Christine , Palygin Oleg , Staruschenko Alexander
Published: September 2023

There is clinical evidence that increased urinary serine proteases are associated with the disease severity in the setting of diabetic nephropathy (DN). Elevation of serine proteases may mediate [Ca2+]i dynamics in podocytes through the protease-activated receptors (PARs) pathway, including associated activation of non-specific cation channels. Cultured human podocytes and freshly isolated glomeruli were used for fluorescence and immunohistochemistry stainings, calcium imaging, Western blot analysis, scanning ion-conductance microscopy, and patch-clamp analysis. Goto-Kakizaki, Wistar, type 2 diabetic nephropathy (T2DN), and a novel PAR1 knockout on T2DN rat background rats were used to test the importance of PAR1-mediated signaling in DN settings. We found that PAR1 activation increases [Ca2+]i via TRPC6 channels. Both human cultured podocytes exposed to high glucose and podocytes from freshly isolated glomeruli of T2DN rats had increased PAR1-mediated [Ca2+]i compared to controls. Imaging experiments revealed that PAR1 activation plays a role in podocyte morphological changes. T2DN rats exhibited a significantly higher response to thrombin and urokinase. Moreover, the plasma concentration of thrombin in T2DN rats was significantly elevated compared to Wistar rats. T2DNPar1-/- rats were embryonically lethal. T2DNPar1+/- rats had a significant decrease in glomerular damage associated with DN liaisons. Overall, this data provides evidence that during the development of DN, elevated levels of serine proteases promote an excessive [Ca2+]i influx in podocytes through the PAR1-TRPC6 signaling, ultimately leading to podocyte apoptosis, the development of albuminuria, and glomeruli damage.
Comparison of melting efficiency between blue, green, and IR lasers in pure copper welding
Authors: Takenaka Keisuke , Sato Yuji , Fujio Shumpei , Tsukamoto Masahiro
Published: September 2023

Pure copper parts are commonly used in many industrial products because of their low thermal resistance and high electrical conductivity. However, connecting high-quality and high-efficiency copper materials remains a challenge. This is because pure copper has low absorption of near-infrared light, making it difficult to weld stably with a near-infrared laser. Visible light lasers should realize high-efficiency laser welding of pure copper. However, there are few reports comparing the laser wavelength dependence of welding efficiency for pure copper. In this study, bead-on-plate welding was performed on pure copper plates of 2 mm thickness using a 1.5 kW blue diode laser (445 nm), a 16 kW IR disk laser (1030 nm), and a 3 kW green disk laser (515 nm). Bead-on-plate welding of pure copper was performed in the thermal conduction mode or the keyhole mode by varying the laser spot diameter and power, and the amount of melting was measured from cross-sectional observations. As a result, compared to the IR disk laser, blue and green lasers showed higher melting efficiency in both the thermal conduction and keyhole modes, and the melting behavior was more stable. In thermal conduction mode welding, the melting efficiency was 0.2% with the IR disk laser and 0.7% with the blue diode laser. In keyhole mode welding, the melting efficiency with the blue diode laser or green disk laser was about 7%, which is equivalent to that with the IR disk laser with 2.5 times the output power.
Serpentine Aneurysm of the Placenta with Good Fetal Outcome
Authors: Haghi Leila
Published: September 2023

We report an exceedingly rare case of placental serpentine aneurysm. A 21-year-old gravida 3 para 1-0-1-1 with the history of a prior C-section presented at 35 weeks of gestation with the complaint of decreasing or absent fetal movements, previously there were no complications during her pregnancy. She underwent an emergent C-section due to non-reassuring fetal heart tones and delivered a female infant weighing 2145 grams without malformation and Apgar scores of 6 and 8 at 1 and 5 minutes. The premature neonate was admitted to the neonatal intensive care unit (NICU) and was discharged a few days later in good health and has done well since. The placenta weighed 768 grams with a three-vessel umbilical cord. The fetal surface was blue-gray and had multiple markedly dilated tortuous vessels (ranging in diameter from 0.5-1.4 cm) which were attached to a single area on the fetal surface. A Verhoeff-Van Gieson stain was negative for elastic fibers. The placental disc had a 7.1 cm peripheral infarct involving approximately 10% of the disc. There have been 3 cases reported previously in which two were associated with intrauterine growth restriction and one with molar transformation. In conclusion, placental serpentine aneurysm is a rare finding and unlike prior cases was associated with prematurity, decreased fetal movements, and nonreassuring fetal heart tones; a good outcome occurred because of prompt medical intervention.
Oral & Maxillofacial Space Infections-A 10-Year Retrospective Study
Authors: Kumar Ashok
Published: September 2023

Oral & Maxillofacial space infections have been recognized since the time of Galen in the second century. In spite of great advances in health care, these infections remain a major problem. Oral & Maxillofacial space infection ranges from periapical abscess to superficial and deep neck infections. The infections generally follow the path of least resistance through connective tissue and along fascial planes [1]. The infections spread to distant sites from the site of origin. Oral & Maxillofacial infections can be potentially lethal infections, at times. Various life-threatening complications associated with oral & maxillofacial infections are respiratory obstruction, necrotizing fasciitis, descending mediastinitis, pericarditis, brain abscess, and sepsis. The successful management of orofacial infection depends on the early recognition of orofacial infection. Appropriate and prompt therapy is mandatory for successful management. Thorough knowledge of anatomy is necessary to predict pathways of spread and to drain these spaces adequately. We present our experience in treating oral & maxillofacial space infection at our centre
Compartment Syndrome of the Hand after Multiple Fractures of the Metacarpals: A Rare Localization with a Poor Prognosis: Two Case Reports and a Literature Review
Authors: W Bouziane
Published: September 2023

Compartment syndrome is a surgical emergency. In fact, it is a “race against the clock” we will discuss our experience with two cases who presented with hand compartment syndrome after suffering numerous metacarpal fractures The treatment included a discharge incisions, metacarpal pinning, and close hand surveillance.
Factors Affecting Utilization of Contraceptives among Women Aged 15-24 Years Attending Fort Portal Regional Referral Hospital, Fort Portal City, Uganda
Authors: Amuza Dhabuliwo
Published: September 2023

Background: Fertility regulation and pregnancy prevention among young women is one of the most important health care issues of the twenty-first century. This is because more than 16 million adolescent girls give birth every year worldwide and an additional 5 million have abortions and Sub Saharan Africa accounts for 50% of these births. As a result, the need for specially tailored child spacing programs for young women has come to the fore of reproductive health services. Methods: Hospital-based cross-sectional study was conducted among women aged 15-24 years attending FRRH prevention from January to March 2021. Data were collected using structured researcher administered questionnaires. Descriptive analysis was used to present frequency and percentage of the main findings. The association between independent variables and determinants of contraceptive use was calculated using Pearson’s Chi square and p-values less than 0.05 were considered as statistically significant. Results: A total of 418 young women aged 15-24 years participated in the study with a 100% response rate. Majority 76.6% were in age category 20-24 years, had attained secondary education 82.5%, were married 62.4%), had a single child 66.3%. Majority of the women felt that their income was not enough 84.2% even though 41.4% were employed. The prevalence of contraceptive use was 95.2%. Age of the women and the contraceptive of choice p=0.001, level of education and contraceptive methods p=0.001, marital status and contraceptive methods p=0.001, discussion with partner and contraceptive uptake p = 0.001, partner’s approval to family planning p = 0.001 and finally contraceptive method with religion p=0.001 were all significant factors of contraceptive use and when all confounders were controlled in a logistic regression model, the factors that remained significant were: The age of women, Level of education, Employment status, discussion with husband/partner on number of children to have and need to have another child. Conclusion: The prevalence of contraceptive use among women aged 15-24 years attending FRRH is higher than the national prevalence and surpasses the national set targets. This is significantly determined by age of the woman, level of education, income levels through employment and opinion of their partners
Identifying drivers of food insecurity through linked data- the Priority Places for Food Index
Authors: Pontin Francesca , Baudains Peter , Ennis Emily , Morris Michelle
Published: September 2023

Introduction & Background15.5% of all UK households are food insecure; either unable to afford to eat, skipping meals or reducing meal sizes despite being hungry. Drivers of food insecurity include both access to and affordability of food, with those most in need often left unable to access healthy and affordable food. Taking a place-based approach to understand the drivers of food insecurity allows for targeted support from government, third sector and private organisations to mitigate growing food insecurity in the UK.

Objectives & ApproachThis research presents the methodology for the co-production and construction of the Priority Places for Food Index (PPFI) and supporting dashboard, co-designed by the Consumer Data Research Centre (CDRC) and consumer champions Which? in response to the 'cost-of-living crisis'.

The PPFI equally weights measures of access to affordable food and indicators of barriers to affording food across seven domains; Proximity to supermarket retail facilities, Accessibility of supermarket retail facilities, Access to online deliveries, Proximity to non-supermarket food provision, Socio-economic barriers, Fuel Poverty and Family Food for support. The PPFI uses open data combing traditional census data metrics, with government data (e.g., Healthy start voucher and free-school meals uptake), digital footprints data (web-scraped delivery addresses and food bank item request data) and scaled-survey data (fuel poverty, propensity to shop online).

Relevance to Digital FootprintsDigital footprint data can complement traditional data sources to provide a more nuanced view of health inequalities. These data are typically less timely to collect than traditional data collection methods (census, survey) allowing a more reactive response to emergent issues such as the cost-of-living crisis.

ResultsThe PPFI interactive map and underlying data have been published via the CDRC https://priorityplaces.cdrc.ac.uk/.

Conclusions & ImplicationsWe demonstrate the value of data linkage across individual and population level data to provide localised insight into food insecurity and identify where digital footprints data can improve gaps in the current evidence base. We also reflect on the value of co-production and stakeholder engagement in creating a policy ready interactive map which has facilitated the lobbying of targeted practical support and policy change to address food insecurity.
Seasonal purchase of antihistamines and ovarian cancer risk in the Cancer Loyalty Card Study (CLOCS): results from an observational case-control study
Authors: Brewer Hannah , Jiang Qianhui , Sundar Sudha , Hirst Yasemin , Flanagan James
Published: September 2023

Introduction & BackgroundAntihistamine use has been associated with a reduction in ovarian cancer incidence. Herein, we investigate antihistamine exposure in relation to ovarian cancer risk using a novel data resource by examining purchase histories from retailer loyalty card data.

Objectives & ApproachParticipants from the Cancer Loyalty Card Study (CLOCS) included ovarian cancer patients (cases, n=153) and women without a diagnosis of ovarian cancer (controls, n=120). Up to 6 years of purchase history was retrieved from two participating high street retailers from 2014-2022. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals for ovarian cancer associated with antihistamine purchases, adjusting for confounders. The association was stratified by season of purchase, age, histology, and family history.

Relevance to Digital FootprintsThis study is one of the first to utilise transaction data from high street retailers to investigate associations with cancer risk, based on what participants are buying.

ResultsEver purchasing antihistamines was not significantly associated with ovarian cancer overall in this small study (OR=0.68 (0.39-1.19)). However, antihistamine purchases were significantly associated with reduced ovarian cancer risk when purchased only in spring and/or summer (OR=0.37 (0.17-0.82)) and in non-serous ovarian cancer (OR=0.41 (0.18-0.93)) in stratified analyses.

Conclusions & ImplicationsAntihistamine purchase is associated with reduced ovarian cancer risk when purchased seasonally. However, larger studies are required to understand the mechanisms of reduced ovarian cancer risk related to seasonal purchases of antihistamines and allergies.
Síndrome do Espaço Sub-Glúteo
Authors:   Serviço de Ortopedia do Hospital da Prelada, Porto, Pato Tiago , Saraiva Daniel , Sá Rodrigues André , Sousa Marco , Tulha José ,   Serviço de Ortopedia do Hospital da Prelada, Porto
Published: September 2023

The deep gluteal syndrome is characterized by pain in the posterior hip and/or groin area, associated or not with pseudosciatica, resulting from an extrapelvic compression of the sciatic nerve in the deep gluteal space. An appropriate knowledge of the clinical presentation, physical examination, and interpretation of complementary exams is essential not only to diagnose, but to understand the cause of the compression and provide an individualized treatment. The authors present a systematic review of the most recent literature on this syndrome, focusing on its anatomy, pathophysiology, clinical assessment, and available treatments.
A doença de Parkinson e o Momento da Fisioterapia
Authors:   Revista de Medicina Desportiva informa, Ribeiro Basil
Published: September 2023

Parkinson’s disease causes motor problems, causing changes on gait, with consequent mobility disturbance and frequent falls. Drug therapy helps to control symptoms, but physical activity has an important functional therapeutic role. Physiotherapy has been very useful for personal and social benefit of these patients. This text presents the results of a study carried out with these patients, in which the timing and frequency of physical therapy sessions were studied. The results revealed long-term advantages in continuous physical therapy, even if the sessions are performed every two weeks.
QUR'ANIC RECEPTION THROUGH NUZULUL QUR'AN COMMEMORATION TRADITION AS A SYMBOL OF COMMUNITY UNIFYING IDENTITY
Authors: Nurani Shinta , Maulana Luthfi , Robani Anidah
Published: September 2023

This article discusses the community's receptivity to the Qur'an based on ethnographic studies in the Commemoration of Nuzul al-Qur'an which was held at the Khoirunnisa' Mosque and Majlis Taklim, Gondang Village, Wonopringgo District, Pekalongan Regency. The people in the area are very heterogeneous and consist of five ideologies namely Nahdlatul Ulama, Muhammadiyah, Rifa'iyah, and Nationalist. The commemoration of Nuzul al-Qur'an in the last 10 days of the month of Ramadan begins with the khataman of the Qur'an, general recitation, then the recitation of four important chapters in the Qur'an, namely Surat Yasin, Surat al-Rahman, Surat al-Waqi'ah, and Surat al-Mulk. The four surahs are believed by the community to be able to maintain security, order, integrity, unity, unity and the community to get ease of life in various ways. This series of commemoration of Nuzul al-Qur'an has been carried out from generation to generation with great enthusiasm and reverence by the community. Even though the heterogeneity of society is very high, the Commemoration of Nuzul al-Qur'an is able to become a symbol of the unifying identity of Muslim communities that bridges the diversity of societal ideologies.
STUDY OF THE PRACTICE OF READING SURAH AL-ISRA VERSES 79-82 AT DUHA TIME AT HIDAYATUL ISLAMIYAH PESANTREN
Authors: Wahid Abd. , Erdina Dewi Putri , Mahmudulhassan M
Published: September 2023

The early tradition of reading Surah al-Isra by the Prophet. done at night which is read in its entirety before the Prophet Saw sleep. This is different from the phenomenon that occurs at the Hidayatul Islamiyah Islamic Boarding School, where they only practice four verses from Surah al-Isra, namely verses 79-82 which are read during duha. Based on this phenomenon, the researcher examines the practice, understanding of teachers and students and the meaning of these readings. This research is a qualitative research with a field study approach. Data was collected through observation techniques, interviews and documentation. The results showed that reading Surah al-Isra verses 79-82 was carried out in congregation after the Duha prayer followed by recitation of remembrance and other prayers. The teacher's understanding of the four verses is in line with the exegetes' interpretation, but not perfect. While the students' understanding of the contents of the verse can be grouped into two, namely understanding based on the translation of the pronunciation only, and understanding of the interpretation of the verse in general. Their understanding is also in line with the interpretation of the interpreter and the understanding of the teacher. As for the meaning of the practice of reciting Surah al-Isra verses 79-82, they include giving peace and self-submission to Allah Swt, ease in studying knowledge, smooth sustenance and closeness to Allah Swt and departure in worship.
Theoretical study of dangers, threats and risks in the economic security of the enterprise
Authors:   Dnipro University of Technology, Arkhypenko T. , Ivanova M. ,   Dnipro University of Technology
Published: September 2023

This article provides a theoretical study and generalization of the definition of the essence of danger, threat and risk in the economic security of an enterprise. The presence of danger creates a system of organizational and economic actions to protect the enterprise from the onset of risk. Schematically, the interdependence of these categories is shown which correlate with each other. At the same time, the systematization method was used to identify deterministic features and the grouping method to clarify conceptual approaches. The aim of the work is to clarify the categorical apparatus of hazards threats and risks in the context of economic security of enterprises for the successful operation of business entities in modern conditions. In the course of the theoretical study, it was possible to systematize the determining signs of danger from the point of view of the possibility of causing harm, violation of the state of balance and ignoring. The analysis revealed the existence of a process of forming terminology, strengthening the scientific justification of the definitions of the definitions "danger", "threat" and "risk". Definitions force business entities to strengthen their protection and, accordingly become competitive in the market. In case of negative events top managers gain experience and this can be considered a starting point on the way to creating sustainable business activities since the identification of obstacles that stand in the way of sustainability of the enterprise must be constantly resolved. The ability of a business entity to recover from devastating events and adapt to changes is increasingly becoming a priority especially given that most of them face disruptions in the last period of time starting with the emergence of obstacles to the COVID-19 pandemic and the war in Ukraine.
Development of applied compliance tools at domestic enterprises
Authors:   Lviv Polytechnic National University, Bortnikova Mariana , Stasyuk Nazar ,   Lviv Polytechnic National University, Malynovska Yuliia ,   Lviv Polytechnic National University
Published: September 2023

The essence of the concept of "compliance" as a complex of measures to protect business from abuses and inefficient management of the organization by its management, as well as the ability to impeccably and consciously act in accordance with the law and internal norms and values established by the company for employees of all levels in order to protect the economic security of the company and maintaining its business reputation. The reasons that encourage enterprises to implement compliance tools have been identified. Article outlined the goals, objectives and functions of compliance. Authors have formed the main components of the organization's compliance policy (code of corporate ethics or corporate conduct; fair competition policy; anti-money laundering policy; policy on receiving and giving gifts and invitations; policy on reporting violations of ethical standards; policy regulating conflict of interests; company property protection policy; information confidentiality policy). Described ways to minimize the risks of enterprises using the implementation of compliance system tools. Highlighted the key problems of implementing compliance at Ukrainian enterprises, namely: insufficient automation of business processes; insufficient number of qualified employees in the field of compliance; incorrect perception by company employees of compliance functions; insufficient understanding of the company's stakeholders about the importance of compliance implementation. The stages of the unified technology of compliance at domestic enterprises have been developed, which includes: the compliance object selection; approval and preparation of the compliance control plan; preparation of the regulatory framework; confirmation of auditors' powers and inspection of the compliance facility; the choice of specific methods of collecting, analyzing and processing the received information; the object of compliance control state assessment; forming conclusions based on the results of compliance; organization of a system of control measures for the implementation of recommended management decisions within the framework of the compliance procedure. A conceptual model of compliance is proposed and substantiated the necessity of its implementation in the practical organizations' activities.