bluuebunny/crossref_metadata_2025 huggingface dataset:
Faculty & Management Perspective Of T.Q.M Implementation At Medical Universities/ Colleges/ Teaching Hospitals of The City of Lahore (Pakistan)
Authors: Farhan Qadir
Published: December 2023

Corporate sustainability and consumer eco-emotion is one of the emerging topics in Pakistan. It is the important according to Pakistan circumstances to measure the interest of consumer towards corporate sustainability. That why this research has been done to find out the relationship and impact of consumer eco-emotion and corporate sustainability. This research contributes towards the individual consumer response, guilt attitude, buying behavior and perception of individual for exploitation of company which is very common factor on Pakistan.  The research is conducted with the help of primary and secondary data source of data. Secondary data include articles, journals, newspaper, websites and books. Primary data include questionnaire which I distributed throughout different location in Lahore. It is a consumer based research so I circulated questionnaire among different consumer with the sample size of 300 respondent. In the current research study. I have applied demographic analysis test (to determine the frequency distribution). In statistical analysis first of all I checked reliability of test tool by Cronbach’ Alpha test then check the normality of data by applying normality test. Then I applied correlation, linear regression.one way ANOVA and cross tabulation to identify and determine the strength of relationship of consumer eco-emotion with corporate sustainability. The entire process of hypothesis testing and analysis has been done by using SPSS 20.It is showed from the findings of study that a weak correlation exist between consumer eco-emotion and corporate sustainability. Consumer eco-emotion shows its weak relation for corporate sustainability, corporate social responsibility and corporate environmental responsibility. Companies should have to increase their trust in the eyes of the consumer for social activities. The guilt is not present in Pakistani consumer so this is the main factor and alarming situation for companies and consumer. Demographics of consumer also measure in this research which show the relationship with sustainable organization.
Principio de Imputación de Precios de Carl Menger: Fundamentos y Aplicaciones
Authors: Bustamante Rafael
Published: December 2023

Este artículo analiza el principio de imputación de precios de Carl Menger y su influencia en la economía. Para ello se contextualiza su obra, y su teoría del valor subjetivo que generó un gran desafío a las teorías tradicionales de la época, al sostener que los precios se basan en las valoraciones subjetivas individuales, y no en los costos de producción. El principio se fundamenta en que los precios de los factores productivos se determinan por su contribución al valor final del bien. Menger destaca la gran importancia de la utilidad marginal junto con la acción humana en el mecanismo de formación de precios. Además, se examina la interacción entre la economía social de mercado y la fijación de precios, donde el Estado regula ciertos sectores para mantener la estabilidad y proteger a los consumidores versus la propuesta de Menger, donde se argumenta que esta última es notablemente superior.
Economía Social y Solidaria
Authors: Ávalos Eloy
Published: December 2023

El presente documento expone la concepción del la economía social y solidaria, desarrollando su definición y campo, como proyecto utópico y de acción colectiva. Asimismo se presenta la relación de la economía social y solidaria y el concepto de necesidades humanas. Finalmente, se aborda el concepto desde una perspectiva de la transformación económica y política.
The influence of beauty makeup web celebrity live streaming on the purchase intention of female consumers--the intermediary role based on trust
Authors: Chen Yuehan
Published: December 2023

This paper applies the SOR theory, this paper studies the influence of the popularity of anchors and the interaction of the broadcast room on the purchase intention, and introduces the trust as the intermediary variable to explore the intermediary role of trust in it. In this study, 162 questionnaires were collected for analysis. The results show that the popularity of the host on consumer purchase intention is not significant, the studio interaction on consumer purchase intention and positive correlation, the introduction of trust as an intermediary variable, the results show that the trust in the studio interactive consumer purchase intention before some intermediary role, trust in the host popularity and purchase intention play a complete intermediary role.
Analysis of the optimal profit strategy of network cargo based on game theory
Authors: Dou Yaodan
Published: December 2023

With the popularity of social media, the Internet celebrity economy has become a new economic phenomenon, driven by huge interests, more and more people enter the industry, one of the main ways to bring goods is targeted sales by celebrities relying on their huge fan base. However, the development of the network with the goods industry is also uneven, there are unqualified products, supervision is not in place and other problems, some carriers pay attention to the interests of blind selling goods at the expense of consumer interests, this behavior is not conducive to long-term development. Therefore, this paper analyzes the optimal profit of online goods by using Nash equilibrium on the basis of considering the interests of consumers. The key to improve profits is to reduce the return rate, and to reduce the return rate lies in whether the marketing subject can control the quality of the goods. On this basis, the probability of monitoring and non-monitoring of the marketing platform is set, and the income of the marketing platform under the strategy of product control and non-control, and consumers under the strategy of purchase and non-purchase is obtained by using repeated games. The optimal profit of online delivery and how to maintain long-term interests are analyzed. Finally, it is concluded that the long-term profit can be obtained when the control cost is low, the control profit is high, the marketing platform penalty and deduction are low and the discount rate is high.
Manfaat Teknologi Ilmu Pendidikan Islam Dunia Maya Dalam Meningkatkan Kualitas Pendidikan Agama Islam
Authors: Khoiriyah Saqdiatul
Published: December 2023

The background of this study is the lack of understanding regarding cyber Islamic education technology. To overcome this, Islamic education technology can be used which contains official related internet sites. The formulation of the problem in this study is what are the benefits of cyber Islamic education technology. Therefore, this study is intended to explain the benefits of cyber Islamic education technology. This is a qualitative descriptive research on library research. Based on the research results, it can be concluded that the benefits of cyber Islamic education technology can improve the quality of Islamic religious education.
Manajemen Strategi Kepala Madrasah Dalam Membangun Budaya Religius Di Lingkungan Madrasah Aliyah Negeri 2 Padangsidimpuan
Authors: Dongoran Siti Rahma
Published: December 2023

The aim of this research is to describe the religious culture in the Madrasah Aliyah Negeri 2 Padangsidimpuan environment, and to describe the strategic management of the madrasa head in building religious culture in the Madrasah Aliyah Negeri 2 Padangsidimpuan environment. This research uses a qualitative method with a descriptive approach. The primary data for this research was obtained directly from interviews with the head of Madrasah Aliyah Negeri 2 Padangsidimpuan, for secondary data in this research in the form of photos, documents and videos during the research. Data collection techniques were carried out using observation, interviews and documentation. Data analysis in this research is by data reduction. The triangulation method was used to check the validity of this research data. Data validity checking method that uses something different from the data for checking or comparison. According to the results of the research, religious culture in Madrasah Aliyah Negeri 2 Padangsidimpuan includes holding morning assembly, reading prayers and verses from the Koran before starting lessons, getting used to praying Dhuha and midday prayers in congregation, and carrying out Islamic activities. And the strategic management of the madrasa head in developing religious culture at Madrasah Aliyah Negeri 2 Padangsidimpuan is by having planning, partnership, habituation, organizing, directing, monitoring and evaluating
Pandemi Sonrası Yoğun Bakım Hemşirelerinde Covid-19 Stres Düzeyinin Belirlenmesi
Authors: PAKLACI Elif , KAYA AYDOĞDU Elif , ÖREN Besey
Published: December 2023

Amaç: Küresel bir sağlık tehdidi olarak karşımıza çıkan COVID-19 hastalık sürecinde yoğun bakım hemşireleri birçok psikolojik sorun ile karşı karşıya kalmıştır. Tanımlayıcı ve kesitsel olarak planlanan bu çalışmada amaç; yoğun bakım hemşirelerinde COVID-19 pandemisine bağlı ortaya çıkan stres düzeyinin belirlenmesidir.

Gereç ve Yöntem: Çalışma yoğun bakımda aktif olarak çalışan 88 hemşire ile online olarak yürütüldü. Veriler 21 sorudan oluşan kişisel bilgi formu ve COVID-19 Stres Ölçeği ile toplandı. Verilerin analizi için SPSS versiyon 25.0 programı kullanıldı. İstatistiksel değerlendirmede bağımsız değişkenler ile ölçek puan ortalaması arasındaki farkları belirlemek için Independet Samples t testi, one-way ANOVA testi, Mann-Whitney U testi ve Kruskal-Wallis analizi kullanıldı. Anlamlılık düzeyi 0,05 olarak kabul edildi.

Bulgular: Hemşirelerin yaş median değeri 34.50±8,16 olarak bulundu. Araştırmaya katılan hemşirelerin %70.5’i COVID-19 pandemisinden etkilendiğini ifade etti. Hemşirelerin ortalama 1.30±0.56 (min:1, max:4) defa COVID- 19 enfeksiyonu geçirmiş olduğu belirlendi. Katılımcıların %85.2’si COVID-19 pandemisinin hemşirelik mesleğini, %90.9’u ise mesleki yönden kendisini pozitif etkilediğini ifade etmektedir. Çocuk sayısı arttıkça tehlike ve bulaşma, sosyoekonomik sonuçlar ve zenofobi alt boyutlarının ortalama puanlarının arttığı görüldü. Gelir düzeyi ile tehlike ve bulaşma, sosyoekonomik sonuçlar, travmatik stres ortalama alt boyutları arasında anlamlı bir ilişki bulundu (p
Toronto Yara Semptom Değerlendirme Sistemi ile Yara Bakımının İzlenmesi
Authors: ŞAHİN KÖZE Burçak , ÖZBAYIR Türkan
Published: December 2023

Amaç: Araştırma Toronto Yara Semptom Değerlendirme Sistemi-TYSDS ile yara bakımının izlenmesi amacıyla yapılmıştır.

Gereç ve Yöntem: Araştırma bir üniversite hastanesinin dahili ve cerrahi kliniklerinde ve yoğun bakımlarında yürütülmüştür. Araştırmanın örneklemini 92 yarası olan 76 hasta oluşturmuştur. Çalışma verilerinin toplanmasında bilgilendirilmiş onam formu, birey tanıtım formu ve TYSDS kullanılmıştır. Verilerin istatistiksel değerlendirilmesi SPSS (Statistical Package for Social Science) programı kullanılarak sayı yüzde, ortalama (x), standart sapma (Sd), Shapiro Wilk Testi, Mann Whitney U, Spearman Korelasyon Analizi ve Wilcoxon analizleri yapılmıştır.

Bulgular: TYSDS’ne göre yara semptomlarının değerlendirildiği birinci ve yedinci günlerde en yüksek puanı estetik olarak sıkıntının, en düşük puanı ise kaşıntının aldığı saptanmıştır. Hastaların yaşları ile birinci ve yedinci günde TYSDS toplam puanları arasında negatif yönde ilişki olduğu saptanmıştır. Hastaların alkol ve sigara kullanım durumları ile yedinci gün TYSDS toplam puanları açısından aralarında istatistiksel olarak anlamlı fark olduğu saptanmıştır (p
YOĞUN BAKIMDA TOKSİK EPİDERMAL NEKROLİZLİ HASTA BAKIMI
Authors: AKBAŞ UYSAL Duygu , ŞENUZUN AYKAR Fisun
Published: December 2023

Giriş: Toksik epidermal nekroliz(TEN) ilaçların yol açtığı, şiddetli deri nekrozuyla beraber sistemik semptomların da olduğu advers reaksiyondur. Genellikle yüksek derecede morbidite ve mortalite ile ilişkilidir. TEN’in sıklıkla antibiyotik ve antikonvülzan ilaç kullanımına bağlı olarak geliştiği bildirilmektedir

Olgu Sunumu

Bilinen alzheimer ve hipertansiyon hastalığı olan 85 yaşındaki kadın hasta , iki gündür tüm vücutta yaygın kızarıklık deride soyulma şikayetleri ile acil servise başvurmuştur. Evde ateş nedeniyle çok fazla antibiyotik kullanan hasta toksik epidermal nekroz ön tanısıyla yoğun bakıma yatırılmıştır. Fizik muayene bulguları; hasta koopere değil, kan basıncı 160/90 mmHg, nabız 110/̈dk, ateşi 37.7°C olarak kaydedilmiştir. Tüm vücutta özellikle hastanın kollarında ve sırtında erode alanlar mevcuttur. Deride yaygın kırmızı ve mor renk değişimi vardır. Göz ve oral mukoza tutulumu mevcuttur. Toksik epidermal nekrolizis tedavisi için immunglobulin verilmiş ve hemşirelik bakım uygulamaları yoğunlaştırılmıştır.

Hemşirelik Bakımı: Ağız yarasından dolayı beslenmesini yeterince sağlayamayan hastaya, beslenme ve enerji gereksinimini karşılamak amacı ile nazogastrik sonda takılmıştır. İkinci derece yanık olgusu gibi yara yeri değerlendirilen hastanın, cilt yüzeyinden ciddi oranda sıvı kaybı olması üzerine hastanın hemodinamisinin sağlanması için yoğun sıvı desteği verilmiştir. Sıvı elektrolit takibi sık aralıklarla yapılmıştır.

Sonuç: TEN vakalarının yönetimi, en iyi sonucu sağlamak için profesyoneller arası bir ekip yaklaşımıyla yapılmalıdır.

Anahtar kelimeler: toksik epidermal nekroliz, yanık yoğun bakım, hemşirelik bakımı
Guerra Fría y ajedrez: El match Fischer-Spassky
Authors: Fernández Jorge
Published: December 2023

A lo largo del siglo XX, el arte de la diplomacia fue adquiriendo nuevas herramientas. Una de ellas puede ser denominada “Ludodiplomacia”, que consiste en ejercer influencia por medio del deporte o de diferentes juegos. En los años de entre guerra, los movimientos fascistas comprendieron este tipo de iniciativa, organizando un mundial de fútbol en Italia (1934) y los Juegos Olímpicos en Alemania (1936). Posteriormente, una forma orgánica de este tipo de diplomacia alcanza un desarrollo más sutil en la Guerra Fría. El ajedrez, conocido como “el juego de los reyes”, fue uno de los aspectos clave en la política exterior de las grandes potencias, alcanzando su auge en el match de 1972, entre el norteamericano Bobby Fischer y el ruso Boris Spassky.
Türkmen Türkçesinde Sakla- Fiili
Authors: BEŞEN DELİCE Tuna
Published: December 2023

Türk lehçelerinde gösteren-gösterilen bağlamında yapılan sözcük ve anlam bilim çalışmaları, lehçeler arası metin aktarmaları için gereklidir. Bu düşünceden yola çıkılarak bu çalışmada Türkmen Türkçesinin söz varlığında yer alan “sakla-“ fiili ele alınmıştır. Bu fiil, Türkmen Türkçesinde kullanım alanının yaygın olması ve Türkiye Türkçesine yapılan metin aktarmalarında farklı fiillerle karşılanıyor olması dolayısıyla bildiriye konu olmuştur. Amaç, her iki lehçede var olan sakla- göstergesinin Türkmen Türkçesindeki anlam ve kullanım alanlarını belirlemek ve elde edilen verileri Türkiye Türkçesindeki aynı dil göstergesi ile karşılaştırarak değerlendirmektir. Bu yolla her iki lehçede aslında eş değer gibi görünen bir fiilin Türkmen ve Türkiye Türkçesinde aynı anlamda olmadığı gösterilmiştir. Böylece yalancı eş değerlik konusunun yalnız temel anlamla değil, yan anlamlarla da ilgili olduğu gerçeği “sakla-“ fiili örneğinde yeniden ortaya konmuştur. Çalışmada Türkmen ve Türkiye Türkçesinin sözlüklerindeki tanımların karşılaştırılması suretiyle sakla- fiilinin farklı kullanımları belirlenmiş; bu bilgi doğrultusunda Türkmen Türkçesinin edebî eserleri, yazılı basını, ders kitapları, atasözleri ve deyimlerinde “sakla-“ fiilinin geçtiği tanık cümleler ve sözcük öbekleri derlenmiş ve eş değerlik bakımından incelenmiştir. “Sakla-“ fiilinin Türkiye Türkçesindeki karşılığıyla örtüşen ve örtüşmeyen anlamları ortaya konmuştur.
Ranking of European Universities by DEA-Based Sustainability Indicator
Authors: Matulová Markéta
Published: December 2023

The paper introduces a novel approach to university rankings that considers a university's contribution to sustainable development. It addresses the usual controversies surrounding the construction of rankings using composite indicators. The conventional approach typically involves normalizing sub-indicators and applying subjective weights for aggregation, which raises concerns about the reliability of the rankings. In response to this issue, we propose an alternative method based on Data Envelopment Analysis (DEA) that utilizes flexible weights. Our approach is applied to the data from the UI-GreenMetric World University Ranking. We initially employ a general Benefit of the Doubt DEA model and subsequently enhance its discrimination power by computing super-efficiency. In the third model, we impose weight restrictions on sub-indicators. The results of our analysis offer valuable insights for all stakeholders, as illustrated by the implications derived for Czech universities included in the sample. Furthermore, we compare the results of universities in various European countries, establishing a connection between rankings and the fulfillment of Sustainable Development Goals (SDG) within individual countries. This research contributes to a more comprehensive understanding of the relationship between university performance, sustainability, and the associated implications for policy and benchmarking.
Assessing the Relative Impact of Colombian Higher Education Institutions Using Fuzzy Data Envelopment Analysis (Fuzzy-DEA) in State Evaluations
Authors: Zuluaga Rohemi , Camelo-Guarín Alicia , De La Hoz Enrique
Published: December 2023

This research aims to design a helpful methodology for estimating universities' relative impact on students as a sustainability factor in higher education. To this end, the research methodology implemented a two-stage approach. The first stage involves the relative efficiency analysis of the study units using Fuzzy Data Envelopment Analysis. The second stage consists of a predictive evaluation of the efficiency of the study units. Consequently, among the most relevant results of the research, it is observed that the methodology identifies the institutions that need to strengthen the academic competencies of the industrial engineering program. Additionally, we developed a benchmark analysis called Efficient Route to help inefficient units achieve efficiency, associating efficiency, and sustainability as pillars of higher education processes.
Text and knowledge in the aspect of large language models
Authors: Orekhov Boris Valer'evich
Published: December 2023

The focus of this text is on the influence of large linguistic models on the self-determination of the humanities. Large language models are able to generate plausible texts. It seems that they thus become on a par with other tools that, throughout the development of technology have freed people from routine. At the same time, for the humanities, the individualization of the generated texts is very great, and knowledge itself is closely related to its textual embodiment. If we agree that knowledge is a text, and embodied in another text, another knowledge appears before us, then humanities will have to answer the question of how a text generated by a person differs in value from the same text generated by a machine. The text of the work raises methodological and epistemological problems of the correlation of texts of natural and artificial origin if they are made in the genre of a scientific work. The difference between such artifacts is clearly visible only for some scientific disciplines, and raises questions about the rest. These issues should be resolved with the help of deep reflection, which was not so urgently needed in the last centuries of the development of the humanities, but which is now required from a humanitarian scientist. The humanitarian will have to explicitly oppose himself to large language models and prove the importance of his work compared to what a neural network can generate.
Application of variation modeling to reconstruct the size of the medieval rural population (using the example of the Pskov land in the middle of the 16th century)
Authors: Shpirko Sergey
Published: December 2023

As part of an interdisciplinary approach, historians are increasingly using the ideas and methods of the mathematical sciences in their research. This, for example, arises in reconstruction problems from the field of historical geography, when the initial data is insufficient for traditional analysis. The subject of this study is to model the system of spatial distribution of the medieval population and demonstrate its results using a specific example. To take into account the condition of territory heterogeneity during modeling, the author develops a variational approach proposed by S.M. Huseyn-Zade. Using the methods of the calculus of variations and Pareto optimality within the framework of this approach makes it possible to identify and numerically describe the relationships between the optimal parameters of the system. To solve this problem of reconstruction, a model of a two-level hierarchy of placement of centers was previously proposed. Its approbation on the material of the scribal description of the Shelonskaya Pyatina of the Novgorod land at the end of the 15th century showed a high degree of correlation between real and theoretical data. The first surviving scribal description of the Pskov lands dates back to the second half of the 80s XVI century. It records a huge mass of abandoned lands as a result of the Livonian War. To assess the scale of this crisis, we first need data on the size of the rural population in the previous period of time. Unfortunately, the scribal description of the mid-16th century, which is closest to it in time, has not survived. However, the above-mentioned first surviving scribal description contains retrospective information about an earlier time, which makes it possible to apply the modeling results to solve the desired reconstruction problem, which is novel.
Students’ Spatial and Visual Literacies
Authors: Fan Yun , Xia Xiang
Published: December 2023

This research examines whether different disciplinary backgrounds influence the development of design students’ visual literacy. A compulsory first-year course in Chinese design degree programmes was selected for this research, as such a course is designed to develop students’ spatial literacy and visual expression during the discovery design process phase and to facilitate the development of students’ cognitive skills in defining and solving problems. An analysis of 16 students’ assignments from eight universities indicates that students’ disciplinary backgrounds play an important role in the development of their cognition performance related to visual literacy. The results indicate that the disciplinary subject background (i.e. arts or engineering) is an important factor affecting the development of students’ design literacy, specifically their spatial visual cognitive and problem-solving skills.
Editorial I. Perspectives on Design Literacy
Authors: Bohemia Erik , Bravo Úrsula , Nielsen Liv Merete
Published: December 2023

Knowledge and skills are tightly entangled with economic and political power. In past agricultural societies, most of the population required skills such as animal husbandry for food and sewing clothing to keep warm. Centuries later, with the advent of an economy centred on the extraction of natural resources and the production of consumer goods, it was necessary to develop more complex skills that enabled people to integrate into emerging societies. School systems were responsible for initiating this process through the ‘literacy’ of the child population. They provided the content and conditions for children to develop the skills needed to read, understand and produce written texts. This approach, albeit with some nuances, was the predominant perspective until the second half of the twentieth century, when new understandings of literacy emerged due to rapid technological advances and critical perspectives that questioned the role of the school in reproducing social relations of power and control (Arredondo & Corzo, 2017; Southwell, 2013).
Municipalismo al rescate. Derechos, sujetos y política relocalizada: el caso de Barcelona (2015-2019)
Authors: Aparicio Marco
Published: December 2023

En España, tras la crisis de 2008 y los profundos impactos que tuvo en las mayorías sociales y en el debilitamiento de los derechos, la movilización de la ciudadanía se expresó, entre otras formas, a través de la ‘apuesta municipalista’ que eclosiona en 2015. El presente texto pretende ofrecer una reflexión sobre los alcances, los retos y los límites de dicha apuesta a partir de un ejemplo concreto, el que ofrece la ciudad de Barcelona con la llegada al poder local de Barcelona en Comú, un partido surgido en buena medida de tales movilizaciones y liderado por Ada Colau, quien fuera la principal portavoz de la Plataforma de Afectados y Afectadas por la Hipoteca (PAH), uno de los fenómenos más notorios de la movilización social en los últimos años. La presente contribución parte de una concepción crítica de los derechos sociales, en el sentido de rechazar su reducción a prestaciones despolitizadas y centradas en el Estado en forma de acceso a los servicios o a la provisión de materiales y, desde tal perspectiva, se pregunta por el modo en que las apuestas políticas municipalistas han sido capaces o no de ofrecer otro tipo de respuestas y de interaccionar de manera constructiva con los movimientos sociales.
La región mendosanjuanina. Una nueva territorialidad económica para Mendoza, San Juan y San Luis en el siglo XVIII
Authors: Sovarzo Jose
Published: December 2023

Este artículo busca demostrar la existencia de una territorialidad económica llamada la región mendosanjuanina para el siglo XVIII, así como problematizar la existencia económica de lo que la historiografía denomina Cuyo. Para ello se analiza a las economías de Mendoza, San Juan y San Luis a partir de distintas variables y dinámicas económicas. Las conclusiones alcanzadas permiten analizar las diferencias existentes entre la economía de la región mendosanjuanina y San Luis. El trabajo combina la utilización de los datos aportados por la historiografía y por las fuentes documentales conservadas en el Archivo General de la Provincia de Mendoza y el Archivo General de la Nación Argentina.
Prácticas de evaluación e intervención fonoaudiológica en niñas y niños bilingües hablantes de lenguas originarias
Authors: Salinas Marchant Carolina , Alvarez Andrade Milena
Published: December 2023

Investigaciones recientes han documentado escasez de fonoaudiólogas/os multilingües y falta de herramientas para trabajar con niñas y niños que aprenden más de una lengua. Este estudio explora los procesos de evaluación e intervención fonoaudiológica orientada a niñas y niños bilingües que, además del español, hablan alguna de las lenguas originarias presentes en Chile. En esta investigación cualitativa, la producción de información se realizó por medio de entrevistas semiestructuradas, que abordaron cuatro objetivos específicos: caracterización de fonoaudiólogas/os, descripción de la evaluación fonoaudiológica, descripción de la intervención fonoaudiológica, y descripción de las adaptaciones a la evaluación e intervención fonoaudiológicas. Se reportan seis categorías de análisis, que dan cuenta de factores que inciden en la evaluación e intervención fonoaudiológicas. La triangulación por investigadores externos corrobora el análisis propuesto por las autoras. Los hallazgos muestran falta de herramientas y de formación profesional para el trabajo con bilingües en lengua nativa. Las profesionales adaptan sus prácticas para dar cuenta de las reales habilidades lingüístico-comunicativas de sus usuarias/os. Se dan sugerencias para enfrentar los vacíos en la formación profesional.
Bernales, M. & Fernández, M. (eds.) (2020). No Podemos Callar. Catolicismo, espacio público y oposición política, Chile 1975 – 1981. Santiago: Ediciones Universidad Alberto Hurtado, Chile. 407 pp.
Authors: Moya Muñoz Patricio
Published: December 2023

Reseña del libro: Bernales, M. & Fernández, M. (eds.) (2020). No Podemos Callar. Catolicismo, espacio público y oposición política, Chile 1975 – 1981. Santiago: Ediciones Universidad Alberto Hurtado, Chile. 407 pp.
Golpe de Estado e Historia pública: la batalla por las narrativas sobre el pasado durante la postdictadura chilena
Authors: Aceituno Silva David
Published: December 2023

En la postdictadura se debió enfrentar a desafíos complejos, gobernar la democracia en coincidencia con miembros de la recién terminada Dictadura era un problema difícil de sortear. En este contexto, enfrentar el pasado reciente desde las narrativas oficiales requería de equilibrios frágiles. En este artículo analizamos de qué manera se configura el debate y desarrollo de la Historia publica sobre el golpe de Estado durante los primeros años del retorno a la democracia. Analizamos como los relatos del oficialismo, intelectuales de derecha e historiadores entran en la batalla por el pasado y proponen sus narrativas. Finalmente pudimos dar cuenta de la relevancia de la investigación histórica para combatir la distorsión del pasado, observando los riesgos que tiene el ceder los espacios discursivos públicos a individuos o grupos que buscan consolidar intereses a través de errores y desinformación sobre la Historia reciente chilena.
Entrelazando memorias de mujeres en territorios periféricos sobre el Golpe de Estado Cívico-Militar en Chile.
Authors: Carrillo Mardones Olga Aurora , González Quitulef Hernán , Sanhueza Rodríguez Alexis
Published: December 2023

Las memorias de mujeres en territorios periféricos son fundamentales para comprender el impacto político-social del Golpe de Estado en Chile, contribuye a visibilizar los procesos subalternizados por la historiografía centrada en las dinámicas político-sociales de las grandes urbes. Este artículo constituye un proceso de indagación y rescate de la memoria a través de los testimonios de mujeres en las regiones del Biobío, La Araucanía, Los Ríos y Los Lagos. Con este propósito, buscamos entrelazar los testimonios invisibilizados a través del estudio de la memoria, destacando el rol de las mujeres en los aspectos políticos, históricos y sociales que subyacen al Golpe de Estado y que dan cuenta de las vivencias en los territorios periféricos. La investigación es cualitativa y se planteó como un estudio de casos múltiples a través de un trabajo de campo en el cual se desarrollaron entrevistas grupales y en profundidad. El análisis de los datos se realizó a partir de un proceso de codificación abierta con el propósito de desarrollar categorías de manera inductiva. A través de la articulación de las narrativas, los resultados dan cuenta de cuatro categorías: (1) quiebre democrático y repercusión en la vida cotidiana; (2) experiencias de violencia; (3) miedo y trauma, (4) resguardo familiar y cuidados colectivos. Los hallazgos nos permitieron descubrir las formas de vida que adoptaron las poblaciones una vez gestado el quiebre institucional de 1973, así como las formas de resistencia y dinámicas de cuidados entre las mujeres en los territorios periféricos del sur de Chile.
SOCIAL MEDIA INFLUENCER’S AND SMEs PERFORMANCE IN OGUN STATE, NIGERIA.
Authors: ADETAYO Adeola E. , ARIYO Oludayo O.
Published: December 2023

This study examined the effect of social media influencer’s on SMEs performance in Ogun State, Nigeria. The research hypotheses were validated using the regression analysis. The data for the analysis were collected by the researcher using a questionnaire as the research instrument. The study used a random sample from the population of registered SMEs in the selected local government in Ogun State. From the result of the analysis, the study revealed that SMIs dimensions (authenticity and trustworthiness) have positive, significant and combine effects on SMEs performance with coefficient and p-value of β1 0.850= (p-value<0.000) and β2 0.854= (p-value<0.000) at F-stat=5.943 (0.000) and adj. R2 = 0.605. Therefore, it is concluded that SMEs performance can be achieved using authenticity and trustworthiness of social media influencers. It is recommended that SMIs should be authentic and trustworthy in every of their deals which leads to increase in SMEs performance in terms of profitability and large market share.
Tackling Alcohol-Related Road Traffic Injuries is an Urgent Public Health Priority in Tanzania and across East Africa
Authors: Swahn, Ph.D. Monica
Published: December 2023

IJADR Commentary
Transition Metal Oxide‐Decorated MXenes as Drugless Nanoarchitectonics for Enriched Nanocatalytic Chemodynamic Treatment
Authors: Xia Hong‐Ying , Li Bo‐Yi , Ye Ying‐Tong , Wang Shi‐Bin , Chen Ai‐Zheng , Kankala Ranjith Kumar
Published: December 2023

Despite their unique characteristics, 2D MXenes with sole photothermal conversion ability are required to explore their superfluous abilities in biomedicine. The small‐molecule‐based chemotherapeutics suffer from various shortcomings of time‐consuming and expensiveness concerning theoretical and performance (preclinical/clinical) checks. This study demonstrates the fabrication of Ti3C2 MXene nanosheets (TC‐MX NSs) and subsequent decoration with transition metal oxides, that is, copper oxide (Cu2O/MX, CO‐MX NCs) as drugless nanoarchitectonics for synergistic photothermal (PTT)–chemodynamic therapeutic (CDT) efficacies. Initially, the monolayer/few‐layered TC‐MX NSs are prepared using the chemical etching‐assisted ultrasonic exfoliation method and then deposited with Cu2O nanoconstructs using the in situ reduction method. Further, the photothermal ablation under near‐infrared (NIR)‐II laser irradiation shows PTT effects of CO‐MX NCs. The deposited Cu2O on TC‐MX NSs facilitates the release of copper (Cu+) ions in the acidic microenvironment intracellularly for Fenton‐like reaction‐assisted CDT effects and enriched PTT effects synergistically. Mechanistically, these deadly free radicals intracellularly imbalance the glutathione (GSH) levels and result in mitochondrial dysfunction, inducing apoptosis of 4T1 cells. Finally, the in vivo investigations in BALB/c mice confirm the substantial ablation of breast carcinoma. Together, these findings demonstrate the potential synergistic PTT–CDT effects of the designed CO‐MX NCs as drugless nanoarchitectonics against breast carcinoma.
The Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of gastric cancer, 2023
Authors: Wang Feng‐Hua , Zhang Xiao‐Tian , Tang Lei , Wu Qi , Cai Mu‐Yan , Li Yuan‐Fang , Qu Xiu‐Juan , Qiu Hong , Zhang Yu‐Jing , Ying Jie‐Er , Zhang Jun , Sun Ling‐Yu , Lin Rong‐Bo , Wang Chang , Liu Hao , Qiu Miao‐Zhen , Guan Wen‐Long , Rao Sheng‐Xiang , Ji Jia‐Fu , Xin Yan , Sheng Wei‐Qi , Xu Hui‐Mian , Zhou Zhi‐Wei , Zhou Ai‐Ping , Jin Jing , Yuan Xiang‐Lin , Bi Feng , Liu Tian‐Shu , Liang Han , Zhang Yan‐Qiao , Li Guo‐Xin , Liang Jun , Liu Bao‐Rui , Shen Lin , Li Jin , Xu Rui‐Hua
Published: December 2023

The 2023 update of the Chinese Society of Clinical Oncology (CSCO) Clinical Guidelines for Gastric Cancer focuses on standardizing cancer diagnosis and treatment in China, reflecting the latest advancements in evidence‐based medicine, healthcare resource availability, and precision medicine. These updates address the differences in epidemiological characteristics, clinicopathological features, tumor biology, treatment patterns, and drug selections between Eastern and Western gastric cancer patients. Key revisions include a structured template for imaging diagnosis reports, updated standards for molecular marker testing in pathological diagnosis, and an elevated recommendation for neoadjuvant chemotherapy in stage III gastric cancer. For advanced metastatic gastric cancer, the guidelines introduce new recommendations for immunotherapy, anti‐angiogenic therapy and targeted drugs, along with updated management strategies for human epidermal growth factor receptor 2 (HER2)‐positive and deficient DNA mismatch repair (dMMR)/microsatellite instability‐high (MSI‐H) patients. Additionally, the guidelines offer detailed screening recommendations for hereditary gastric cancer and an appendix listing drug treatment regimens for various stages of gastric cancer. The 2023 CSCO Clinical Guidelines for Gastric Cancer updates are based on both Chinese and international clinical research and expert consensus to enhance their applicability and relevance in clinical practice, particularly in the heterogeneous healthcare landscape of China, while maintaining a commitment to scientific rigor, impartiality, and timely revisions.
CD14 down‐modulation as a real‐time biomarker in Kawasaki disease
Authors: Inada Yutaro , Sonoda Motoshi , Mizuno Yumi , Yamamura Kenichiro , Motomura Yoshitomo , Takuma Aoba , Murata Kenji , Furuno Kenji , Tezuka Junichiro , Sakai Yasunari , Ohga Shouichi , Kishimoto Junji , Hosaka Koki , Sakata Satomi , Hara Toshiro
Published: December 2023

Objectives

The objectives of this study were to investigate the pathophysiology of Kawasaki disease (KD) from immunological and oxidative stress perspectives, and to identify real‐time biomarkers linked to innate immunity and oxidative stress in KD.

Methods

We prospectively enrolled 85 patients with KD and 135 patients with diverse conditions including immune, infectious and non‐infectious diseases for this investigation. Flow cytometry was used to analyse the surface expression of CD14, CD38 and CD62L on monocytes, along with a quantitative assessment of CD14 down‐modulation. Additionally, oxidative stress levels were evaluated using derivatives of reactive oxygen metabolites (d‐ROMs) and antioxidant capacity measured by a free radical elective evaluator system.

Results

During the acute phase of KD, we observed a prominent CD14 down‐modulation on monocytes, reflecting the indirect detection of circulating innate immune molecular patterns. Moreover, patients with KD showed a significantly higher CD14 down‐modulation compared with infectious and non‐infectious disease controls. Notably, the surface expression of CD14 on monocytes was restored concurrently with responses to intravenous immunoglobulin and infliximab treatment in KD. Furthermore, d‐ROM levels in patients with KD were significantly elevated compared with patients with infectious and non‐infectious diseases. Following intravenous immunoglobulin treatment, oxidative stress levels decreased in patients with KD.

Conclusion

Monitoring CD14 down‐modulation on monocytes in real‐time is a valuable strategy for assessing treatment response, distinguishing KD relapse from concomitant infections and selecting second‐line therapy after IVIG treatment in KD patients. The interplay between inflammation and oxidative stress likely plays a crucial role in the development of KD.
PF457 MECHANISM OF MORPHOLOGICAL REMODELING OF BONE MARROW ADIPOCYTES IN ACUTE MYELOID LEUKEMIA
Authors: Yang S. , Lu W. , Zhao C. , Zhai Y. , Wei Y. , Liu J. , Yu Y. , Li Z. , Shi J.
Published: December 2023

Background:

We have previously found that morphological remodeling of bone marrow adipocytes in acute myeloid leukemia (AML) patients is closely related to poor prognosis, and growth differentiation factor 15 (GDF15) may be a key factor in this pathological phenomenon.

Aims:

In this study, we further explored the mechanism of GDF15 regulating the bone marrow adipocyte remodeling from the perspective of calcium channel TRPV4.

Methods:

GDF15‐induced adipocytes were analyzed using gene expression profiling, and gene knockdown cells were generated by lentiviral‐mediated shRNA. Chip‐qPCR was used to evaluate the interaction between transcription factors and TRPV4. Signaling pathway downstream of GDF15 involved in adipocytes was analyzed by inhibitor experiments. An experimental AML mouse model was generated to investigate the role of TRPV4 in leukemia cell‐induced bone marrow adipocyte remodeling.

Results:

Western blot and RT‐qPCR showed that GDF15 could regulate TRPV4 expression in bone marrow adipocytes. In vitro, Transwell assay and neutralizing antibody assay further found that GDF15 secreted by leukemia cells regulated bone marrow adipocyte remodeling through TRPV4. The phenomenon was verified in obese C57/BL6 mice. Specific inhibition experiments showed that GDF15 secreted by leukemia cells combined with TGFβRII in bone marrow adipocytes, and then activated PI3K / AKT pathway. Using RNA‐Seq technique, we found that transcription factor FOXC1 mediated the inhibition of GDF15 on TRPV4 expression in bone marrow adipocytes, which causes the morphological remodeling of bone marrow adipocytes.

Summary/Conclusion:

GDF15 secreted by leukemia cells inhibits the expression of TRPV4 by regulating the transcription factor FOXC1 in bone marrow adipocytes, which promote the lipolysis of adipocytes. The free fatty acids released by this process provide energy support for the growth of leukemia cells. This paper provides a new perspective for the study of leukemia cell remodeling of bone marrow adipocyte microenvironment.
PF497 INFLAMMATION‐DRIVEN HEME/IRON CYTOTOXICITY IN PARKINSON'S DISEASE
Authors: Lima I. , Pêgo A.C. , Martins A.C. , Sá Pereira I. , Martins G. , Kapitão A. , Gozzelino R.
Published: December 2023

Background:

Heme is a metallo‐compound, essential for the survival of most organisms. However, the ability of the central iron (Fe) atom, contained within its protoporphyrin ring, to participate in the Fenton reaction and generate highly reactive hydroxyl radicals renders heme potentially toxic. Under inflammatory conditions, the release of heme from hemoproteins leads to an exacerbated oxidative stress, a deleterious effect associated with tissue damage and disease severity.

Aims:

As immune‐mediated inflammatory diseases often cause a certain degree of hemolysis and vascular leakage, it is reasonable to assume that the cytotoxicity of heme/Fe may also affect less accessible organs, such as the brain, thus increasing the risk and severity of neurodegenerative diseases.

Methods:

This hypothesis has been investigated in mice, in which the exogenous administration of heme or the release of this molecule upon inflammation/infectionwas shown to enhance the severity of Parkinson's disease (PD). An increased susceptibility to pharmacologic PD was observed when mice are exposed to heme and subsequently treated with 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP), a neurotoxin precursor that, once converted into the active metabolite, irreversibly damages the dopaminergic neurons (DNs).

Results:

Our results demonstrate that from circulation, heme is capable to enter the brain and trigger neuroinflammation. While this is associated with the recruitment of immune cells, which breach the BBB and enter the brain, an increased level of circulating heme was shown to contribute to the occurrence of brain Fe overload, causing an exacerbated locomotor dysfunction in response to PD induction.

Summary/Conclusion:

Therefore, our findings suggest that the release of heme in circulation upon immune‐mediated inflammatory diseases is capable to prime the brain and contribute to the development of neurodegenerative diseases, such as PD.
Exploring the potential of phenolic and antioxidant compounds in new Rosaceae fruits
Authors: Razola‐Díaz María del Carmen , Aznar‐Ramos María José , Benítez Guillermo , Gómez‐Caravaca Ana María , Verardo Vito
Published: December 2023

BACKGROUND

Rosaceae fruits have been used in traditional medicine for the prevention and treatment of diseases. However, these fruits have not extensively been studied regarding their phenolic composition. Thus, this research focuses on the determination of phenolic compounds by high‐performance liquid chromatography electrospray ionization time‐of‐flight mass spectrometry, flavan‐3‐ols by high‐performance liquid chromatography with fluorescence detection, and the antioxidant activity by 2,2‐diphenyl‐1‐picrylhydrazyl, 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid), and ferric reducing antioxidant power of the fruits of five species of genera Crataegus and Sorbus (Rosaceae).

RESULTS

We found a total of 71 phenolic compounds from which 30 were identified in these berries for the first time. Crataegus monogyna and Crataegus laciniata revealed higher total phenolic and flavan‐3‐ol contents than the other species and the highest antioxidant activities.

CONCLUSIONS

Therefore, the fruits evaluated have demonstrated to be important sources of bioactive compounds with huge potential for being used in nutraceutical or food scopes. Additional studies could be needed to evaluate the influence of the different production areas on the phenolic content. © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Encounter between Gyroid and Lamellae in Janus Colloidal Particles Self‐Assembled by a Rod–Coil Block Copolymer
Authors: Huang Chunzhi , Zhang Xinyue , Lyu Xiaolin
Published: December 2023

Controlling the internal structure of block copolymer (BCP) particles has a significant influence on its functionalities. Here, a structure‐controlling method is proposed to regulate the internal structure of BCP Janus colloidal particles using different surfactants. Different microphase separation processes take place in two connected halves of the Janus particles. An order‐order transition between gyroid and lamellar phases is observed in polymeric colloids. The epitaxial growth during the structural transformation from gyroid to lamellar phase undergoes a two‐layered rearrangement to accommodate the interdomain spacing mismatch between these two phases. This self‐assembly behavior can be ascribed to the preferential wetting of BCP chains at the interface, which can change the chain conformation of different blocks. The Janus colloidal particles can further experience a reversible phase transition by restructuring the polymer particles under solvent vapor. It is anticipated that the new phase behavior found in Janus particles can not only enrich the self‐assembly study of BCPs but also provide opportunities for various applications based on Janus particles with ordered structures.
Influence of seawater sea sand concrete environment on the long‐term tensile properties of pultruded basalt and basalt‐carbon‐hybrid fiber reinforced polymer profiles
Authors: Su Chang , Wang Xin , Ding Lining , Zhou Jingyang , Chen Zhiyuan , Wu Zhishen
Published: December 2023

To reveal the durability of fiber‐reinforced polymer (FRP) profiles, which differ from FRP bars due to the clear variations in the internal structure of the fibers. This study experimentally investigated the tensile properties of FRP profiles in the seawater sea sand concrete (SSC) environment at 25, 45, and 60°C. Unidirectional basalt FRP profiles, multidirectional basalt FRP profiles, and basalt and carbon hybrid FRP profiles were considered. SEM analysis was performed to evaluate the corrosion mechanism. Results show that the strength degradation of FRP profiles accelerated with rising ambient temperature due to resin corrosion in hyperthermia. After 63 days of immersion in the SSC environment solution, multidirectional basalt FRP (BFRP) profiles exhibited more severe corrosion than unidirectional BFRP profiles (82.5% and 88.2%, respectively). The hybrid FRP profiles exhibited a strength retention of 86.4%, which was higher than that of multidirectional BFRP profiles due to the superior alkali resistance of carbon fibers compared to basalt fibers. In addition, prediction models of FRP profiles based on the Arrhenius relation were proposed with a high correlation coefficient of R2.

Highlights

Durability of FRP profiles in SSC environment was studied.

Basalt and carbon fibers hybrid reinforced multidirectional polymer profiles.

Corrosion mechanism of FRP profiles was revealed.

Tensile property prediction model of FRPs in SSC environment was proposed.