bluuebunny/crossref_metadata_2025 huggingface dataset:
Deletion of the Brain-Specific α and δ Isoforms of Adapter Protein SH2B1 Protects Mice From Obesity
Authors: Cote Jessica L. , Argetsinger Lawrence S. , Flores Anabel , Rupp Alan C. , Cline Joel M. , DeSantis Lauren C. , Bedard Alexander H. , Bagchi Devika P. , Vander Paul B. , Cacciaglia Abrielle M. , Clutter Erik S. , Chandrashekar Gowri , MacDougald Ormond A. , Myers Martin G. , Carter-Su Christin
Published: November 2020

Mice lacking SH2B1 and humans with variants of SH2B1 display severe obesity and insulin resistance. SH2B1 is an adapter protein that is recruited to the receptors of multiple hormones and neurotrophic factors. Of the four known alternatively spliced SH2B1 isoforms, SH2B1β and SH2B1γ exhibit ubiquitous expression, whereas SH2B1α and SH2B1δ are essentially restricted to the brain. To understand the roles for SH2B1α and SH2B1δ in energy balance and glucose metabolism, we generated mice lacking these brain-specific isoforms (αδ knockout [αδKO] mice). αδKO mice exhibit decreased food intake, protection from weight gain on standard and high-fat diets, and an adiposity-dependent improvement in glucose homeostasis. SH2B1 has been suggested to impact energy balance via the modulation of leptin action. However, αδKO mice exhibit leptin sensitivity that is similar to that of wild-type mice by multiple measures. Thus, decreasing the abundance of SH2B1α and/or SH2B1δ relative to the other SH2B1 isoforms likely shifts energy balance toward a lean phenotype via a primarily leptin-independent mechanism. Our findings suggest that the different alternatively spliced isoforms of SH2B1 perform different functions in vivo.
Deletion of the brain-specific α and δ isoforms of adapter protein SH2B1 protects mice from obesity
Authors: Admin Ada , Cote Jessica L. , Argetsinger Lawrence S. , Flores Anabel , Rupp Alan C. , Cline Joel M. , DeSantis Lauren C. , Bedard Alexander H. , Bagchi Devika P. , Vander Paul B. , Cacciaglia Abrielle M. , Clutter Erik S. , Chandrashekar Gowri , MacDougald Ormond A. , Jr Martin G. Myers, , Carter-Su Christin
Published: November 2020

Mice lacking SH2B1 and humans with inactivating
mutations of SH2B1 display severe obesity and insulin resistance. SH2B1 is an adapter protein
that is recruited to the receptors of multiple hormones and neurotrophic
factors. Of the four known
alternatively-spliced SH2B1 isoforms, SH2B1b and SH2B1g exhibit
ubiquitous expression, whereas SH2B1a and SH2B1d are
essentially restricted to the brain. To understand the roles for SH2B1a and SH2B1d in energy
balance and glucose metabolism, we generated mice lacking these brain-specific isoforms
(adKO
mice). adKO mice exhibit decreased food intake, protection from
weight gain on standard and high fat diets, and an adiposity-dependent
improvement in glucose homeostasis. SH2B1 has been suggested to impact energy
balance via the modulation of leptin action. However, adKO mice exhibit leptin sensitivity that
is similar to that of wild-type mice by multiple measures. Thus, decreasing the
abundance of SH2B1a and/or SH2B1d relative to the other SH2B1 isoforms
likely shifts energy balance towards a lean phenotype via a primarily leptin-independent
mechanism. Our findings
suggest that the different alternatively-spliced isoforms of SH2B1 perform
different functions in vivo.
CEPT1-Mediated Phospholipogenesis Regulates Endothelial Cell Function and Ischemia-Induced Angiogenesis Through PPARα
Authors: Admin Ada , Zayed Mohamed A. , Jin Xiaohua , Yang Chao , Belaygorod Larisa , Engel Connor , Desai Kshitij , Harroun Nikolai , Saffaf Omar , Patterson Bruce W. , Hsu Fong-Fu , Semenkovich Clay F.
Published: November 2020

De novo phosopholipogenesis, mediated by
choline-ethanolamine phosphotransferase 1 (CEPT1), is essential for
phospholipid activation of transcription factors such as peroxisome proliferator-activated receptor α (PPARα) in the liver. Fenofibrate, a PPARα agonist and
lipid-lowering agent, decreases amputation incidence in patients with diabetes.
Since we previously observed that CEPT1 is elevated in carotid plaque of patients
with diabetes, we evaluated the role of CEPT1 in peripheral arteries and PPARα-phosphorylation (Ser12). CEPT1 was found to be elevated in diseased
lower extremity arterial intima of individuals with peripheral arterial disease
and diabetes. To evaluate the role of Cept1
in the endothelium, we engineered a conditional endothelial cell (EC)-specific
deletion of Cept1 via induced VE-cadherin-CreERT2 mediated
recombination (Cept1Lp/LpCre+). Cept1Lp/LpCre+ ECs demonstrated
decreased proliferation, migration, and tubule formation, and Cept1Lp/LpCre+ mice had reduced
perfusion and angiogenesis in ischemic hind-limbs. Peripheral ischemic recovery
and PPARα signaling was further compromised
by Streptozotocin-induced diabetes, and ameliorated by feeding fenofibrate. Cept1 esiRNA decreased PPARα-phosphorylation in ECs, which
was rescued with fenofibrate but not PC16:0/18:1. Unlike Cept1Lp/LpCre+, Cept1Lp/LpCre+Ppara-/-
mice did not demonstrate hind-paw perfusion recovery after feeding fenofibrate. Therefore we demonstrate that CEPT1 is
essential for EC function and tissue recovery following ischemia, and that fenofibrate
rescues CEPT1-mediated activation of PPARα.
Practical implementation of laser polishing on additively manufactured metallic components
Authors: McDonald Mark W. , Gora Wojciech S. , Stevenson Stuart G. , Weston Nick J. , Hand Duncan P.
Published: November 2020

Due to the continually increasing popularity of metal powder-based additive manufacturing as a production process in recent years, there has been growing research into improving the surface quality of the parts manufactured in this way. Laser polishing offers great potential as a finishing technique due to its flexibility and suitability for automation. However, the complexity of components that can be produced with additive manufacturing processes presents challenges in developing practical and flexible arrangements for implementing a laser polishing process. In this paper, we offer methods to manage height variations of parts using weakly focused beams, process components that are (roughly) cylindrical using rotational stages, and polishing of internal surfaces using simple optics. As an example application, we present finishing of additively manufactured cobalt chrome dental implants to a surface roughness of 0.45 μm in only 60 s using a low-cost fiber delivered diode array laser.
APPLICATION OF ENTROPY BASED TOPSIS IN ANALYSIS OF SUSTAINABILITY PERFORMANCE OF SRI LANKA HOTELS
Authors: Weerathunga PR , Xiaofang Cheng , Samarathunga WHMS , Kulathunga KMMCB
Published: November 2020

Sustainability is the limelight of many industries, especially in developing countries. In the hospitality industry, in particular, sustainability plays a pivotal role since it contributes immensely to the economy of a country. However, the hospitality industry is increasingly facing various challenges due to the uncertainty and instability in the business environment. Thus, the central focus of this study is to evaluate the sustainability performance of Sri Lankan hotels industry. For this purpose, 25 hotels were selected from the hotels listed in the Colombo Stock Exchange (CSE). In order to determine the sustainability performance of the selected hotel, we identified 18 indicators that represent the economic, environmental, and social and governance sustainability. Then, we developed a multidimensional sustainability performance index system and using entropy-based TOPSIS, the values of the individual indicators were aggregated. Eventually, we rank the hotels based on the TOPSIS scores, which represent the sustainability performance of hotels. The resulted TOPSIS scores reveal that the Sri Lanka hotels’ sustainable performance is moderately high. This indicates that there is a growing tendency to adopt more sustainable practices among hotels companies in Sri Lank. Recently, stakeholders in the state and private sector have paid much attention to the tourism industry because it has tremendous potential and many prospects, and the same is reflected in our results. While we are providing important implications for managers and policymakers, our findings urge the hotels with a lowlevel sustainability performance to go for more sustainable practices.
MEDIA COVERAGE, POLITICAL CONNECTIONS AND CORPORATE RISK
Authors: Yi Zhou , Youtang Zhang
Published: November 2020

Media coverage, as an important part of the external corporate governance mechanism, plays an important guiding role in corporate behavior patterns and public opinion. Taking A-share listed companies of Shanghai Stock Exchange and Shenzhen Stock Exchange from 2012 to 2017 as research examples, this paper analyzed how media coverage and political connections exert influence on corporate risk in an empirical study approach. This paper makes the following conclusions. First, the media, as information medium and external participant of the company, significantly lower the listed company’s corporate risk through closed media coverage. Second, the closer connection a company has with government, the higher corporate risk it encounters and, in the meantime, less effect of media coverage’s aversion effect towards corporate risk. Third, based on a further research on the nature of company’s property rights, this paper revealed that in state-owned companies, close political connections weaken much more media coverage’s aversion effect towards corporate risk than that in private companies.
Profitability Analysis of Paddy and Locally Milled Rice (oryza sativa L.) Marketing in the Federal Capital Territory, Nigeria
Authors: Ebukiba E. S. , Ogbole E. O.
Published: November 2020

The study investigated and compared the profitability of paddy and locally rice marketing in the Federal Capital Territory. Primary data was collected using pre-tested well-structured questionnaires through the adoption of multistage sampling technique. Descriptive statistics (mean, percentage and frequency) were used to analyze data for the socioeconomic characteristics of respondents and constraints of marketing both commodities in the study area while gross margin analysis was used to determine the cost and returns of marketing the commodities. The results for the socioeconomic characteristics of respondents sampled revealed that 61% and 71% of paddy and locally milled rice marketers respectively were between the ages of 31 – 50 years, majority (54%) of the respondents had attained some form of formal education, 74% and 48% of paddy and locally milled rice marketers respectively had over 11years of marketing experience while 75% of paddy rice marketers as against 45% of locally milled rice marketers belonged to a marketing association. The results for cost and returns of marketing the commodities revealed that paddy rice marketers with a total revenue of N59,965and gross margin of N41,711 made 51% more profit that their locally milled rice counterparts with a total revenue and gross margin of N44,646.35 and N20,427respectively. It was also revealed that marketing paddy and locally milled rice in the area were affected by challenges such as high transportation cost, unfavourable government policies, and inadequate and obsolete processing facilities. The study concludes that paddy rice marketing is more profitable in the Federal Capital Territory and thus recommends the formulation and implementation of government policies centered on marketing locally produced rice such as imposition of higher tariffs on importers and traders of imported rice as well as the provision of modern day storage facilities to facilitate storage of paddy rice.
Effect of Seed Pre- Germination Treatment and Light Regimes on The Germination and Growth of Myrianthus Arboreus (P. Beauv) Seedlings
Authors: Oboho E. G. , Omaku F. F. , Anozie E. L.
Published: November 2020

The effects of seed pre-treatment methods on the germination and growth of Myrianthus arboreus under two light regimes was conducted in the nursery of the Department of Forest Resources and Wildlife Management, University of Benin, Benin City. The seed pre-treatment methods were 24 hours soaking in water (T1), 12 hours soaking in water (T2), seeds tied in black nylon (T3), control no treatment (T4) and repeated under two light regimes which were open light regime and medium light regime. Experiment was set up in Completely Randomized Design manner (CRD.) Analysis of variance was used to analyze the results of germination and growth parameters measured.

Germination percentages in the open light regime were 52, 56, 52 and 56% for T1, T2,T3, and T4 respectively while germination percentage in the medium light regime were 100, 64, 0 and 32% for T1, T2, T3, and T4 respectively. The mean shoot heights (cm) were 10.22 and 5.36 in the open light regime and medium light regime respectively. Collar girths (mm) were 1.99 and 1.11 number of leaves were 3.39 and 2.23 while the mean shoot to root ratio was 1.01 and 0.99 for the open light regime and the medium light regime respectively.

Therefore, it is recommended that the seeds of Myrianthus arboreus be soaked in water for 24 hours, sown under medium transferred at the 2-leaf stage to the open light regime (or shading removed) where they will grow until planting out time.
Simultaneous Use of AMMI Model and Yield for Stability Analysis of Wheat Genotypes Evaluated Under Central Zone of the India
Authors: Verma Ajay , Singh Gyanendra Pratap
Published: November 2020

AMMI analysis had observed highly significant effects of environment (E), GxE interaction and genotypes (G) during 2018-19 and 2019-20 years of study. Suitability of PBW822, HI8811 & HI8713 genotypes as compared to HD3345 by WAASB measure for first year. Superiority index found HD3345, PBW822 & NIDW1158 as of stable performance with high yield. PRVG measures settled for HI8811, GW322 & HI 8737 and MHPRVG considered HI8811, HI8713 & GW322 wheat genotypes. All negative values of correlations exhibited by SI measure whereas WAASB measure exhibited direct relationships as well as negative values with SI, PRVG, MHPRVG and yield. WAASB measure observed suitability of GW513, HI1636 & MACS6747 wheat genotypes for the second year. Superiority index found GW513, HI1636 & HI1544 as of stable performance along with high yield. PRVG as well as MHPRVG measures observed suitability of GW513, HI1636, & MP1361 while HD3377 as unstable wheat genotype. SI measure had expressed only indirect relations of high degree with other measures except of positive values with yield, PRVG and MHPRVG. Measure WAASB had exhibited direct relations with most of measures along with negative correlation for SI, yield, PRVG and MHPRVG values. Stability measures by simultaneous use of AMMI analysis and average yield of genotypes would be more meaningful as compared to measures based either on the AMMI or yield only.
Effect of Environmental Factors on Growth Kinetics of Biocontrol Agent Bacillus thuringiensis Bacterium using 2L and 5L A+ Sartorius Stedim Biostat® Fermentation Systems
Authors: Richardson C. S. , Upadhyay D. , Mandjiny S. , Holmes L.
Published: November 2020

Bacillus thuringiensis (Bt) is a soil-dwelling, Gram-positive bacterium that is used as a biological pesticide and used to genetically engineer plants due to the toxic proteins it produces. B. thuringiensis was studied in batch cultures to determine the specific growth rates and doubling times. The purpose of this experiment was to research the growth kinetics of Bacillus thuringiensis in a 2L bioreactor and a 5L bioreactor containing growth media at different environmental conditions. Fermentation parameters were controlled by utilizing a Sartorius Stedim Biostat® A+ bioreactor system for bacterial growth. The environmental conditions included temperature, agitation, and aeration. The specific growth rates of B. thuringiensis were determined. The optimal conditions for the 2L bioreactor were 200 RPM, 30°C, 1.5 VVM, and with the highest specific growth rate 0.30 hr and the shortest doubling time 2.3 hr. For the 5L bioreactor, the optimal conditions were 150 RPM, 30°C, 1.5 VVM, and with the highest specific growth rate 1.2 hr and the fastest doubling time 0.6 hr.
Primary Neuroendocrine Tumor of the Testis Masquerading as Germ Cell Tumor – A Case Report
Authors: Manna Sulagna , Narayana Suma Mysore , Premalata C. S.
Published: November 2020

Primary pure neuroendocrine tumors of the testis are rare with a high malignant potential requiring long-term follow-up. Only limited number of studies are available in the literature.

In the present study, we describe a case report of a 31 year old young man who presented with a left testicular swelling, initially misdiagnosed as seminoma. Later, after correlating with the morphology and immunohistochemistry the diagnosis of neuroendocrine tumor of testis was concluded.

Neuroendocrine tumors cases should be kept in long term follow up, to prevent relapse and recurrence.
Sistem Pengelolaan dan Pemanfaatan Harta Pusaka Masyarakat Minangkabau dalam Karya Wisran Hadi
Authors: Basri Irfani , Ratna Ellya
Published: November 2020

This reasearch describes about management and the usage system of harta pusaka in novels wrote by Wisran Hadi. The novel that became the object of this research titled Orang-orang Belanti dan Negeri Perempuan. In this research it is found that basicaly in minangkabau culture they have some rules use as they have in their society. But in fact, thereis also misunderstanding in managing tanah pusaka by man and the government because of thereason of people need. Butital sotells that there is a case that follow the rule in society. For example, in Bundo’s character, as one of the person who receive harta pusaka and can use it without have to overtaking other’s rights. Then, she also canuseit for all. Meanwhile, man that has power tomanage Harta pusaka does not have right to own it.
Cultural Dilemma of The Arab Woman Expressed through Nature Imagery: An Ecocritical Study of Fadia Faqir’s Pillars of Salt
Authors: George Shilpa
Published: November 2020

The Arab community is essentially a patriarchal one with a history of women being subjected to various kinds of afflictions and oppression under cultural, religious and societal laws. Though there is a collective consciousness now regarding the position of the Arab woman in the Arab world, with significant progress being made to emancipate and empower them, much needs to be done still. Set in the mid-20th century Jordan, Arab Anglophone author Fadia Faqir’sPillars of Salt portrays the tragic plight of Arab women at the hands of the traditional patriarchal Arab communities of Jordan. Nature plays a significant role in Faqir’s narrative wherein much of the miseries faced by the women characters are conveyed through rich nature imageries and analogies. This renders the novel the identity of an eco-fictional work and provides scope for analysis based on the ecological approaches as perceived in Emerson’s Nature to the more recent theory of Ecocriticism formulated by William Rueckert. This paper explores an ecocritical approach towards the position of women in the Arab society as expressed through profound eco-comparisons, imageries and analogies in Fadia Faqir’s Pillars of Salt.
Folk Knowledge in Maintaining Group Integration and Socio-economic Intimacy among the Arsi-Robe Peasants
Authors: Yideg Yeshaw Tesema , Dubi Yosef Beco
Published: November 2020

The purpose of this article is to analyze the folk knowledge in maintaining folk group integration and socio-economic intimacy among the Arsi-Robe peasants. The significance of folk knowledge in folklore of the society in connection with group integration and socio-economic welfare is the case in point. This study employed a field survey research and data gathering method through the participant observation as well as direct interview. In order to obtain the substantial folkloristic data from local sources (people, occasions, or other settings), the researchers had familiarized with the social behavior and local environment of each locality. As far as the findings of this study are concerned, two points may be underscored here. People are customarily designated to take part in group-driven occupational habits like däbo and wänfä. Amongst the Arsi-Robe traditional society, if people isolate themselves from communal works, they are criticized, if not ostracized and excluded from the mainstream social and cultural roles. They also play their potential roles in kinship and kinship-like social relations. Put another way, they make interventions between their own world and a social unit in their vicinities according the collective paradigm set customarily.
Analfabetismo brasileiro
Authors: Tebaldi Evelin Louise Pavan Ribeiro , Lemes Sebastião de Souza
Published: November 2020

Para melhor compreender o analfabetismo brasileiro das últimas quatro décadas, essa pesquisa propôs um estudo comparativo entre o perfil do analfabetismo da década de 1980, traçado por Azevedo (1997) como alto, desigual e renitente, e da década de 2010, observando as transformações ocorridas nesse período, no qual permearam políticas públicas para a universalização da educação básica. Para tanto, foi realizada uma pesquisa documental fundamentada nos Censos Demográficos Nacionais (1980, 1991, 2000, 2010) e uma pesquisa bibliográfica com base em Azevedo (1997), Ferrari (1985), Ferraro e Kreidlow (2004), entre outros. Os resultados indicam que mesmo com a melhora dos índices, o analfabetismo brasileiro se mantém alto, desigual e renitente. Além disso, foi possível evidenciar o peso que a insuficiência do processo de alfabetização institucionalizado tem na produção do analfabetismo escolar e geral, refletindo sobre as questões de acesso, permanência e qualidade da educação.
Vaivenes jurisprudenciales: fumigaciones en la provincia de Entre Ríos
Authors: Moreno Juan Ignacio
Published: November 2020

En la provincia de Entre Ríos se desarrolla un modelo de agricultura industrial que trajo como consecuencias una afectación sobre la salud de niños y docentes de escuelas rurales. Ante un planteo ecológico resulta trascendental que el mismo sea social ya que incide sobre todas las personas. Mediante un análisis de la legislación entrerriana y la causa judicial “Foro Ecologista contra Superior Gobierno de la Provincia de Entre Ríos” (2018-2020) se apreciará la postura mercantilista del agronegocio y el reclamo de los pueblos fumigados que buscan vivir dignamente.
Vigilancia voluntaria y racionalidad excepcional
Authors: Pérez Juan Pablo Ciudad
Published: November 2020

Jean-Jacques Rousseau, en sus obras más tardías, o lo que algunos de sus comentaristas han denominado su segunda fase como pensador (Schneewind, J.B. 2009. pp. 556 y 557), a contrapelo de la tesis central ilustrada de la época – a saber, que la promoción de la razón y el desarrollo científico mejoraría la moralidad de los sujetos y acrecentaría individual y socialmente la felicidad –, sostuvo la tesis que el progreso sería algo inseparable de la tiranía en los asuntos públicos y de la corrupción en los asuntos privados.
La violencia institucional como violencia de género: el espectáculo mediático y el caso irlandés
Authors: Maitini José María , Gizzi Jessica Belen
Published: November 2020

El siguiente escrito analiza críticamente la violencia institucional como violencia de género en el marco de la temática del aborto. El hecho analizado es concreto: un ginecólogo de hospital público recibe a una mujer embarazada producto de una violación y no le permite abortar.  En la sentencia se comprobó que R.P. no pudo acceder al aborto cuando la propia víctima había declarado bajo juramento la violación sufrida. Además, se comprobó que el ginecólogo no se encontraba en la lista de “Objetores de Conciencia”. A pesar de ser claros los hechos, en la población se reflejó "la doble postura" existente acerca del tema. ¿Cómo operan los medios de comunicación en este sentido? ¿qué incosciente colectivo se quiere o necesita moldear?  El trabajo propone reflexionar en torno al rol de los medios de comunicación y la construcción de una subjetividad colectiva que impide el pensamiento jurídico crítico en torno a la temática. Además, nos preguntamos: ¿religión y aborto son incompatibles? Para esto, traemos a colación el caso de Irlanda como ejemplo superador de la dicotomía religión/laicismo para pensar “más allá de la grieta” de esta problemática concreta de salud pública como es el tema del aborto legal, seguro y gratuito.
Ser o no ser
Authors: Colombaro Paola
Published: November 2020

El estudio que aquí se presenta se basa en el análisis crítico de la sentencia que condenó a cadena perpetua Reina Maraz Bejarano (en adelante RM) por el delito de homicidio agravado por el vínculo, para referirme luego a la sentencia que la absolvió. El desafío que asume este trabajo no radica en pensar la inocencia o culpabilidad de Reina, sino en poner de manifiesto la necesidad de mirar el sistema judicial a través de un abordaje epistemológico que contemple la pervivencia de una matriz colonial de poder.
Mujeres responsables: aportes para reflexionar acerca de la carga sexista del discurso jurídico de la responsabilidad
Authors: Almejún Juan Martín
Published: November 2020

El propósito de este trabajo es examinar brevemente la relación entre el lenguaje de la responsabilidad y el lugar que el discurso jurídico le asigna a las mujeres. Se desarrollarán dos ideas:  la Teoría Crítica y la Teoría Feminista han puesto en evidencia que el derecho ha sido históricamente una disciplina machista; esta afirmación se evidencia en el lenguaje judicial y doctrinario y en las categorizaciones de la responsabilidad que subyacen tanto en el derecho privado como en el derecho penal.
Editorial ReDeA Nº 17
Authors: Revista Derechos en Acción
Published: November 2020

Editorial ReDeA Nº 17.
El agro argentino
Authors: Vértiz Patricio
Published: November 2020

En la Argentina, más del 50% de la superficie utilizada para actividades agropecuarias está en manos de sólo el 2,5% de las explotaciones que se dedican a esta actividad. De éstas, las que poseen más de 10.000 ha (el 1% del total) controlan el 36% de la tierra, mientras que las unidades más pequeñas (menores a las 100 ha), que representan el 55% de la totalidad, manejan sólo el 2% de la tierra. En este trabajo se discute la noción de “el campo” en Argentina, teniendo en cuenta la estructura de distribución de la tierra, la diversidad de rubros y actividades que lo conforman y la heterogeneidad de agentes agrarios involucrados. Se aborda críticamente el modelo de organización y funcionamiento de las actividades agroindustriales -los agronegocios- y, en particular, la dimensión tecnológica como uno de sus pilares fundamentales. Finalmente, se presentan una serie de propuestas vinculadas a la intervención estatal en el complejo agroalimentario argentino y al rol de la ciencia y la  tecnología, en un posible  nuevo modelo para el agro que disminuya los niveles de dependencia y permita avanzar al país en materia de soberanía.
Editorial
Authors: Greco Sara , Lobinger Katharina
Published: November 2020

The publication of issue 20(2) of SComS marks an important occasion, namely the 20th anniversary of our journal, which was founded at USI – Università della Svizzera italiana twenty years ago, and consequently published its first issue in early 2001. As you might know, SComS was merged with Medienwissenschaft Schweiz (a publication by the SACM – Swiss Association of Communication and Media Research) in 2007, keeping the name Studies in Communication Sciences. Seizing the occasion of this achievement, we would like to share some important information with you. First, speaking about the history of our journal, we remind you that the early issues of SComS and of Medienwissenschaft Schweiz are fully accessible on our website (section “Archives”), thanks to our collaboration with e-periodica. Second, we are happy to announce that SComS now has an online first publishing policy, meaning that articles are quickly made available online. This policy increases the pace and visibility of articles published in SComS, which is a clear advantage for both our authors and readers. Finally, if you wish to receive regular updates on news, thematic sections and articles published, we encourage you to follow SComS on Twitter (@SComS_Journal). Moving on to discuss the contents of SComS 20(2), we are pleased to announce that this issue contains a variety of topics and perspectives in our field. Alongside a General Section and a Thematic Section, it also contains a Community Section, in which we publish a summary of the PhD thesis that has won the SACM Dissertation Award 2020. Finally, this issue includes a Reviews and Reports Section that comprises two book reviews of recent publications in our field and a report on a scientific workshop held in Zurich.
Aebi, Adrian, Göldi, Susan, Weder, Mirjam (Hrsg.). «Schrift – Bild – Ton. Beiträge zum multimodalen Schreiben in Bildung und professioneller Kommunikation»
Authors: Witt Sabine
Published: November 2020

Changes are taking in place academic writing due to the influence of the English-speaking academic community. While these changes are plain to see, they seldom undergo critical examination when it comes to learning how to wield them. Arlene Archer, a South African writing researcher and Director of the University of Cape Town’s Writing Center, studies this very aspect of academic language. As a keynote speaker at the Forum for Academic Writing conference organized in collaboration with the Lucerne School of Business Institute for Communication and Marketing, she was the sole presenter to draw attention to the political dimension of participation in academia. Using the concept of “voice”, which is to be understood approximately as “discursive self”, she highlights the need for a metalanguage in teaching and learning that will bring visibility to certain limitations on discourse. Archer uses social semiotics to always link the production of meaning in writing with social implications. She focuses on two central aspects of “voice”: the recognizability of authorship, which is expressed in various decisions on how content is selected and presented; and citation, which has the ability to open or close the door to academic conversation like a key. The author then presents a matrix of terms that can be used to ascertain “voice” in multimodal texts. Archer's critical examination of conventions in academic writing is recognizably motivated by Identity Politics and serves in part to empower the disadvantaged. Thus, Archer likewise ties didactics into a political mission that is strongly aimed at reflection and not just the use of resources in a semiotic sense.
Client And Coalitions dalam Implementasi Kebijakan Kesehatan Ibu dan Anak di Kabupaten Kupang
Authors: Rene Mariayani , - Kismartini , Purnaweni Hartuti
Published: November 2020

One important factor that determines the successful implementation of mother and child policy is support from community especially the community whose be the target of the polices (clients) and also certain parties (coalitions) who have an interest in the policy. This paper aims to find clients and coalitions in the implementation of health mothers and children in Kupang Regency, which is one of the regions in Indonesia with the highest infant mortality cases. The method used is descriptive qualitative, by using one indicator in Najam implementation models, namely client and coalitions for analysis. The results of the study show that the implementation of Perda No 3 of 2016 as maternal and child health policy in Kupang Regency has not received support from the community, especially those who are the client of the policy. Therefore, it is recommended that the Kupang Regencial Government increase the socialization to the people in particular who are the clients of this policy
OCORRÊNCIA DE PARASITOS GASTROINTESTINAIS DE GATOS DOMÉSTICOS (Felis catus domesticus) EM AMOSTRAS FECAIS RECEBIDAS NO HOSPITAL VETERINÁRIO DA UNIVERSIDADE ESTADUAL DE SANTA CRUZ NO PERÍODO DE 2018-2019
Authors: Ferreira Luis Eduardo Batista , Ribeiro Luana Araújo , Pinto Jaqueline Maria da Silva
Published: November 2020

O objetivo desse trabalho é avaliar a ocorrência de parasitos gastrointestinais em 20 amostras fecais de gatos domésticos recebidas no Laboratório de Parasitologia Veterinária da Universidade Estadual de Santa Cruz. As amostras foram recebidas no período de 19 de abril de 2018 a 09 de agosto de 2019, sendo de animais de diferentes raças e ambos os sexos. Dessas amostras (15/20) foram negativas e (5/20) foram positivas, onde o foram encontrados com maior frequência ovos de Ancylostoma spp. (4/20) além de uma amostra positiva para oocistos de Cystisospora spp (1/20). Os animais com amostras positivas eram animais com idade inferior á um ano e nunca tinham passado por acompanhamento veterinário. Enquanto o alto número de amostras negativas pode ser justificado por serem animais cuidados por membros da comunidade acadêmica e que já tinham passado por atendimento no Hospital Veterinário, realizando de tratamentos antiparasitários.
Organización y desarrollo de un programa de trasplante hepático en Mar del Plata. Resultados iniciales (2010-2018)
Authors:   Unidad de Cirugía Hepato-Pancreato-Biliar y Trasplante Hepático. Clínica Privada Pueyrredón. Mar del Plata, Buenos Aires, Argentina, Fernández Diego L. , García Federico W. , Bracco Ricardo A.
Published: November 2020

Background: Over the past 30 years, new liver transplant programs have emerged as a response to the increasing use of this therapy to treat irreversible liver failure. Objective: the aim of this presentation is to describe the organization, development and initial results of a Liver Transplant Program in Mar del Plata. Material and methods: A team of professionals trained in liver transplantation was created, with specialists in surgery, anesthesiology, intensive care, hepatology, hemotherapy, hematology, and registered nurses and nurse scrubs granted by regulatory agencies. Building alterations, and technical and adaptations were implemented. Thirty-two transplantations were performed with complete cadaveric donor in patients from neighboring localities (55%) and from Mar del Plata (45%). The most common etiologies of cirrhosis were chronic hepatitis C virus infection and alcohol abuse. Results: Operative mortality was 12.5%. Actuarial survival at 55 months of the 32 recipients was 75%. Six bile drug strictures late postoperative period which were treated successfully trated with a conservative approach Conclusions: the Liver Transplant Program in Mar del Plata provides care to the geographic area of the southeast of the province of Buenos Aires. The initial results are consistent with those expected for the current standards in liver transplantation.
Manajemen pengelolaan informasi departemen humas pt pal indonesia (persero) dalam membangun citra baik perusahaan pada isu bumn merugi di era revolusi industri 4.0
Authors: Kusuma Reri Septiana , Wahyuningsih Sri
Published: November 2020

Information management carried out by PT PAL Indonesia (Persero) uses Instagram as a social media listening in monitoring issues as well as being used as an analytic social media to the audience to determine tastes and segmentation in order to build good corporate image communication. The purpose of this research is to find out how the management of the information department of the Public Relations department of PT PAL Indonesia (Persero) in building a good image of the company on issues related to BUMN loss in the industrial revolution era 4.0. Data collection methods using observation, interviews, and documentation. The informants were selected using purposive sampling method. Data analysis using Miles and Huberman techniques, namely data reduction, data presentation, and drawing conclusions. The results of this study indicate that in the information management carried out by PT PAL Indonesia (Persero) using Instagram as an analytic media as well as in building a good image of the company. PT PAL Indonesia (Persero) set the agenda for each upload to frame the issue of loss-making BUMN that dragged PT PAL Indonesia (Persero) as an effort to form a good image of the company. Keywords: Information Management; Social Media Listening; Agenda Setting; Company Good Image
Leveraging the COVID-19 crisis in making work-from-home a mainstream practice in the oil and gas industry
Authors: Dewi Indira , Adiarsi Gracia Rachmi
Published: November 2020

During the COVID-19 crisis, the oil and gas industry is among industries that face challenges in selling their products and struggling to manage their cash flow. The pressure to improve financial discipline within the oil and gas industry started even before the COVID-19 crisis. This paper validates the feasibility of adopting work-from-home (WFH) as a permanent practice for oil and gas companies in Indonesia and how it will help to reduce costs, enhance employee productivity, and improve their organizational agility. The survey was conducted two weeks after the start of the forced WFH “experiment.” One hundred nine executives from various oil and gas companies in Indonesia took part in the survey. The result of this study resulted in most of the large and established companies in Indonesia, in particular, the oil and gas companies, being slow in adopting this practice. The COVID-19 crisis could be the turning point for wider and lasting adoption of WFH in the oil and gas industry. The survey results validate that business can still run even when their employees are working from home. Also, the survey results showed that a shift of opinion toward accepting WFH as the new normal exists. The survey indicates that many companies have crossed psychological and mental blocks and are receptive to the idea of making WFH part of normal HR practices.Keywords: WFH; Management; Sustainability; Oil and Gas Industry.
Pemanfaatan media sosial bagi pengembangan umkm di desa kedungrejo, kecamatan jabon, sidoarjo
Authors: Istanti Enny , Sanusi Ruchan
Published: November 2020

Social media is a tool or means that can be accessed by everyone without limitation of time and distance as long as there is an internet network. The existence of social media that has wide, easy, and fast access is used by MSME small entrepreneurs to be more courageous in promoting their products as an effective and efficient marketing medium. The rapid development of MSMEs has made the use of social media even higher. The existence of MSMEs is expected to be able to expand employment opportunities, accelerate the process of economic equality, increase community income, and promote national stability. The use of social media is expected to be able to increase the marketing reach of MSME businesses. With the Thematic Real Work Lecture program, it is hoped that outreach and training activities on the development of MSME marketing in Kedungrejo Village through social media can provide an understanding of the importance of social media in developing business while keeping up with the times and can be used as much as possible. Keywords: UMKM; Social media; Extension; Training.
Endocrine disruption and female reproductive health: Implications on cross-talk between endocrine and autocrine/paracrine axes in the ovary
Authors: Biswas Subhasri , Mukherjee Urmi , Maitra Sudipta
Published: November 2020

Female reproduction is a blend of neuroendocrine, endocrine, and autocrine/paracrine factors that maintain the appropriate ovarian micro-environment. The growing urbanization prompted exposure to a myriad of environmental toxins carrying the ability to interfere with reproductive processes governed by endogenous hormones, making reproductive health a major global concern. These environmental anthropogenic contaminants, popularly termed as endocrine-disrupting chemicals (EDCs), can disrupt the ovarian homeostasis leading to serious perturbations, namely, anovulation, infertility, estrogen deficiency, and premature ovarian failure. Although gonadotropin action, biosynthesis of gonadal steroids vis-à-vis growth factors comprise the essential modulators within the ovary, the redox balance along with inflammatory and cell death response can dramatically influence the framework of ovarian dynamics; however, details of which remain relatively less understood. The present overview provides an update on candidates (endocrines and autocrine/paracrine) of oogenesis, and the potential impact of EDCs on diverse intra-ovarian entities including but not limited to gonadotropin action, steroidogenic potential, expression of growth factors, and modulation of maturational competence. Moreover, the relative importance of free radical-induced stress, inflammation, and elevated cell death (follicular atresia), in the regulation of ovarian functions and how these intricate yet conjoined mechanisms may alter the reproductive performance of a female will be an issue of discussion.
Hydroxamic acid-modified peptide microarrays for profiling isozyme-selective interactions and inhibition of histone deacetylases
Authors: Moreno-Yruela Carlos , Bæk, Michael , Vrsanova Adela-Eugenie , Maric Hans M. , Schulte Clemens , Olsen Christian Adam
Published: November 2020

Histones control gene expression by regulating chromatin structure and function. The posttranslational modifications (PTMs) on the side chains of histones form the epigenetic landscape, which is tightly controlled by epigenetic modulator enzymes and further recognized by so-called reader domains. Histone microarrays have been widely applied to investigate histone–reader interactions, but not the transient interactions of Zn2+-dependent histone deacetylase (HDAC) eraser enzymes. Here, we synthesize hydroxamic acid-modified histone peptides and use them in femtomolar microarrays for the direct capture and detection of the four class I HDAC isozymes. Follow-up functional assays in solution demonstrate their suitability to discover HDAC substrates and inhibitors with nanomolar potency and activity in cellular assays. We conclude that similar hydroxamic acid-modified histone peptide microarrays and libraries could find broad application to identify class I HDAC isozyme-specific substrates and facilitate the development of isozyme-selective HDAC inhibitors and probes
Synthesis, Properties, and Derivatization of Poly(dihydrogermane): A Gemanium-based Polyethylene Analogue
Authors: Yu Haoyang , Ni Chuyi , Thiessen Alyxandra , Li Ziqi , Veinot Jonathan G.C.
Published: November 2020

Polygermanes are germanium-based analogues of polyolefins and possess polymer backbones made up catenated Ge atoms. In the present contribution we report the preparation of a stable germanium polyethylene analogue – polydihydrogermane (i.e., (GeH2)n) – via two straightforward approaches that involve topotactic deintercalation of the CaGe Zintl phase. The resulting (GeH2)n possess morphologically dependent chemical and electronic properties and thermally decompose to yield amorphous hydrogenated Ge. We also show that the resulting (GeH2)n provide a platform from which functionalized polygermanes can be prepared via thermally-induced hydrogermylation-mediated pendant group substitution. This facile one-step derivatization reaction exploits Ge–H reactivity and opens the door to a wide array of tailored functional polygermanes.
Polymeric Encapsulation of a Ru(II)-based Photosensitizer for Folate Targeted Photodynamic Therapy of Drug Resistant Cancers
Authors: Karges Johannes , Tharaud Mickaël , Gasser Gilles
Published: November 2020

The currently used photodynamic therapy (PDT) photosensitizers (PSs) are generally associated with a poor cancer cell selectivity, which is responsible for some undesirable side effects. To overcome these problems, the use of selective drug delivery systems is currently envisioned. In this article, the encapsulation of a promising Ru(II) polypyridine complex-based PDT PS in a polymer with terminal folate groups to form nanoparticles is presented. While showing a high selectivity for cancerous cells over non-cancerous cells, the nanoparticles were found to be highly phototoxic in 2D monolayer cells as well as 3D multicellular tumor spheroids upon 480 nm or 595 nm irradiation. Promisingly, the nanoparticles were also active in drug resistant cancer cells lines, indicating that they are able to overcome drug resistances.
When evidence does not matter: The barriers to learning from science in two cases of environmental policy change in Brazil
Authors: de Mattos Donadelli Flavia
Published: November 2020

Abstract
It is generally accepted in public policy debate that expert knowledge tends to contribute to more effective formulation and implementation of policy. Most of the literature, however, has tended to be exclusively focused on the science–policy interface, ignoring the necessary pre-conditions of the broader national and institutional context for the effective use of scientific evidence. This shortcoming becomes particularly pronounced in analysis of developing in less pluralist countries. This article analyses two cases of Brazilian environmental policy-making and discusses the institutional pre-conditions for learning from science. By textually coding instances of direct and indirect participation of scientists in congressional debates and assessing the extent of their influence in final decisions, this article shows that despite being largely consensual to the scientific community, clearly communicated, and relevant, scientific information had no influence on the policy-decisions taken in two highly-technical areas of environmental policy in Brazil: forestry and pesticides. This article engages with the literature on the necessary institutional structures for learning from science and provides support for the hypothesis that countries with lower levels of political openness, and medium-to-low consensus requirements for decision-making, will tend to have considerable barriers to effectively producing evidence-based policy-making.
Machinery of Government Reforms in New Zealand
Authors: de Mattos Donadelli Flavia , Lodge Martin
Published: November 2020

This article assesses the reasons for frequent national-level administrative reforms in New Zealand and reflects on their potential consequences. It explores three potential reasons: the particularities of Wellington as a highly conducive place for ideas to be shared between decision makers and academics; the characteristics of New Zealand institutions; and the effects of innovations themselves as drivers of disappointment and more innovation. The article reflects on reforms as drivers of continuous and incremental improvements as opposed to a hyper-innovative, politically driven administrative system. It concludes by stressing the importance of incorporating experiences ‘from the bottom’ in reform processes, and reliance on reflective mechanisms capable of creating opportunities for incremental, piecemeal and often ‘inelegant’ administrative adjustments.
Cross-Sector Partnership in New Zealand Local Government: A Case of Affordable Housing Policy for Older People in Auckland
Authors: Kim Daewook , Cho Wonhyuk
Published: November 2020

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Dilema dan Problematik Desain Industri di Indonesia
Authors: Sulistianingsih Dewi , Satata Bagas Bilowo Nurtantyono
Published: November 2020

Industrial design is one part of the scope of intellectual property that gets protection from the state by first registering for the design. Issues in industrial design are no less complicated with problems in the scope of other intellectual property, such as patents, brands, inventions. The clash between industrial design and copyright and brand is unavoidable. Designers must be able to understand the existence of industrial design in intellectual property. One of the problems in the body of industrial design is about renewal. The provisions of renewal are one of the reasons for the emergence of cases / cases in claims against industrial design.This study uses a normative juridical method with a legal and conceptual approach. The purpose of this study is to reveal and analyze problems in industrial design in Indonesia. A review of the Industrial Design law is important to do in order to create a law that can accommodate interests in the corridor of legal certainty, justice and expediency.