bluuebunny/crossref_metadata_2025 huggingface dataset:
Achievement of martensite strengthening in titanium alloy thin-walled components via non-equilibrium hot stamping
Authors: CHANG Shupeng
Published: August 2024

Abstract. The hot stamping using cold die technology demonstrates great advantages in improving the forming efficiency of titanium alloy thin-walled components. Martensite has been widely employed to strengthen steels, yet few applications were reported in titanium alloys. The main reason is that the martensite microstructure embrittles titanium alloys easily. In this paper, the non-equilibrium hot stamping technology is proposed for titanium alloys to solve the strength-ductility trade-off caused by martensite microstructure. Rapid heating is used to control phase transformation and grain growth during the short-time heating and obtain non-equilibrium microstructure. Non-equilibrium hot stamping experiments of the Ti-6Al-4V alloy were carried out to validate the feasibility. Results show that the rapid heating in the single β-phase region could avoid overgrowth of β grains and lead to the formation of fully fine martensite after water quenching. An Ω-shaped component with fully martensite microstructure were successfully formed by non-equilibrium hot stamping technology. The formed component has a maximum tensile strength of 1153.9 MPa, with a total elongation of 8.0% at room temperature, and the tensile strength is 13.0% higher than that of the as-received sheet.
Advancing weathering steel through thermomechanical processing and simulation techniques
Authors: REFAIY Hoda
Published: August 2024

Abstract. Thermomechanical processing (TMP) techniques are pivotal in fabricating and advancing weathering steel, a high-strength, low-alloy steel admired for its exceptional corrosion resistance and aesthetic appeal. Combined with numerical and physical simulation methods, these techniques optimize mechanical properties, microstructure, and overall weathering steel performance. Selecting an appropriate steel composition is crucial before applying TMP techniques. Alloying elements like copper, chromium, nickel, and phosphorus are carefully incorporated to enhance corrosion resistance. Once the steel composition is determined, numerical simulations are employed to model and predict the behavior of weathering steel during processing. Hot rolling is the first stage of thermomechanical processing in which weathering steel is heated and deformed in rolling mills. Additionally, numerical simulations can be employed to study other heat treatment steps, normalization and stress relieving, to optimize their parameters and impact on weathering steel's microstructure and mechanical properties. In conjunction with thermomechanical processing techniques, physical simulations, accelerated corrosion testing, and environmental exposure, help assess weathering steel's long-term performance and durability. These techniques provide valuable data on the formation and behaviour of protective patina, contributing to the steel's corrosion resistance. In summary, combining thermomechanical processing techniques and numerical and physical simulations enables the precise control and optimization of weathering steel's mechanical properties, microstructure, and corrosion resistance. These advancements contribute to the development and application of weathering steel in various industries, where its unique combination of mechanical performance, aesthetic appeal, and long-term durability is highly valued.
THE IMPACT OF COVID-19 ON THE USE OF URBAN PUBLIC FACILITIES: EVIDENCE FROM INDONESIA, JAPAN, AND EGYPT
Authors: Setiadi Amos , K. Wardhani Mustika , Wang Zhixi , Rahayu Th. Emi , Mohmed Eldeib M. Abd Alsalam
Published: August 2024

Since COVID-19 emerged in Asia, the function of urban public facilities has been adapted to adapt to the pandemic conditions. This article discusses the use of public facilities during the COVID-19 pandemic in Indonesia, Japan, and Egypt using responses obtained from a questionnaire. The data retrieved were analyzed using the T-test statistical method and descriptive analysis. The results showed that the intensity of public facilities usage was reduced after community activities were restricted. Moreover, the decision to use the facilities tended to be based on the implementation of health protocols regardless of the distance from their homes. This is evident from the number of visits to modern shopping places rather than traditional markets to fulfill daily needs despite the longer distance and this indicates the focus on security and comfort. Information technology was also considered quite helpful in handling the pandemic as well as the latest information related to the development of the pandemic obtained quite easily from print media, announcements in several public facilities, and easily accessible websites.
EXPLORING INSTITUTIONAL INVESTORS’ DETERMINANTS OF INVESTMENT IN AFFORDABLE HOUSING FUND
Authors: Mohd Daud Mohd Ariff , Rosly Saiful Azhar , Muhamad Sori Zulkarnain
Published: August 2024

This study attempts to explore factors that may attract institutional investors to invest in affordable housing funds in Malaysia. Six traits of investments were tested, namely fund structure and mandate, market return, social return, risk mitigation, governance and transparency, and government support for the investment. Based on the six determinants, the study uses a partial least square structural equation modeling (PLS-SEM) technique using data gathered from a survey involving employees of institutional investment firms in Malaysia. The study found three significant factors motivating institutional investors to invest in affordable housing fund, namely social return, government support, and governance and transparency. Overall, it was found that institutional investors do greatly consider social elements in their investment decisions. This will potentially open new avenues in fundraising efforts to build more affordable housing, hence providing an adequate supply of these homes for those in need.
CONSIDERATION OF PLANNING PERMISSION IN SHORT-TERM RESIDENTIAL ACCOMMODATIONS
Authors: Chua Abdullah Nuraisyah , Ramly Ramzyzan
Published: August 2024

Planning permission may be required if the use of the property for short-term residential accommodations (STRA) services constitutes ‘development’ in planning terms. In analysing the possible operational aspects of STRA application in the planning system in Malaysia, the experience of STRA implementation in some selected countries is explored. The article concludes that there are different approaches, which are adopted by different regions concerning the need for planning permission. Most jurisdictions that are “friendly” towards STRAs view that planning permission is not necessary if STRA is managed on a small scale. Hence, it can be concluded that if the scale of the STRA business is big, i.e. ‘commercial’ in nature, planning permission is needed. Alternatively, the local planning authority may consider issuing a provisional or temporary planning permission (TPP), a short-term approval that is only permissible for the transitory nature of the use of land and buildings.
SOCIAL IMPACT ASSESSMENT: A COMPARISON OF THE LEGAL FRAMEWORKS IN MALAYSIA AND NEW ZEALAND
Authors: M Suaree Nur Atheefa Sufeena , Syed Abdul Kader Sharifah Zubaidah , Mohamed Osman Mariana
Published: August 2024

Social Impact Assessment (SIA) has been implemented since the early 1990s, and it is a decision-making tool and methodology for determining the benefits or suffering that affect communities through the social outcomes data. This assessment is crucial in the planning phase as well as the development phase to monitor the impact of proposed development projects. Many countries, including Malaysia and New Zealand, have started implementing SIA within their legal framework to respond to the development cycle proactively. Thus, this paper seeks to compare and analyse the legal frameworks of SIA in Malaysia and New Zealand through qualitative methodologies: library research, content analysis, as well as comparative analysis. The findings show that both countries have legislation relating to SIA; however, the method of implementation is not the same, as SIA in New Zealand has emerged with the Environmental Impact Assessment (EIA) while SIA in Malaysia is implemented on a stand-alone basis.
AIDS SOCIAL EXPENDITURES, POVERTY AND INEQUALITY IN TIME OF COVID-19 PANDEMIC IN INDONESIA
Authors: Anwar Syaiful , Yudaruddin Rizky , Naprida Dewi , Rai Wibowo Bagus , Lesmana Dadang
Published: August 2024

The research investigates the correlation between social aid expenditure and poverty, and inequality across 34 Indonesian provinces from 2004 to 2022. Utilizing the two-step Generalized Method of Moments (GMM) estimate, it examines the impact of social aid expenditure on poverty rates and the Gini coefficient during the COVID-19 pandemic. Results show a significant decrease in the proportion of the impoverished population due to social aid expenditure, with minimal effects on inequality. The study highlights a substantial increase in both poverty and inequality during the pandemic, particularly in rural and urban areas. Analyzing the relationship between social welfare spending and COVID-19 impact reveals a positive influence on disadvantaged populations and inequality in Indonesian provinces. This underscores the need for a comprehensive review of social aid programs, especially amidst COVID-19 challenges.
CONCEPTUALIZATION OF TURNER'S VULNERABILITY – MOUNTAINOUS GEOGRAPHICAL TOURISM SENSITIVITY TO NATURAL DISASTER
Authors: Ak Matusin Ak Mohd Rafiq , Rusli Noradila , Fitry Rosley Muhammad Solehin , Yusof Janatun Naim , Ling Gabriel Hoh Teck
Published: August 2024

While interest in studying the impact of natural disasters on tourism is growing, a noticeable gap exists in exploring destination-level tourism sensitivity, particularly in geographical contexts. This study addresses this gap by using the 2015 Ranau earthquake as a case study to assess the sensitivity of mountainous geographical tourism to natural disasters, employing the Turner Vulnerability Framework. In-depth interviews with Ranau's tourism entrepreneurs and operators, selected through purposive sampling, provide insights, and thematic analysis is conducted to understand qualitative responses comprehensively. The findings reveal that mountain tourism in Ranau showed significant sensitivity to the 2015 earthquake, primarily attributed to the Source element, including tourism products, business size, development, and perceived disaster impact. In contrast, the Power elements exhibited relatively lower sensitivity. These findings underscore the importance of tailoring geographical-based adaptations within tourism systems in response to natural disasters and emphasize integrating natural disaster management into tourism development for long-term sustainability.
DEMOGRAPHIC DYNAMICS AND URBAN PROPERTY CRIME: A LINEAR REGRESSION ANALYSIS IN KUALA LUMPUR AND PUTRAJAYA (2015-2020)
Authors: Ahmad Azizul , Masron Tarmiji , Mohd Ali Asykal Syakinah , Kimura Yoshinari , Junaini Syahrul Nizam
Published: August 2024

In an era where urbanization is rapidly transforming the landscape of cities, this study provides a crucial overview of how demographic shifts influence property crime in metropolitan areas. The paper delves into the complex interplay between property crime rates and demographic characteristics in the urban settings of Kuala Lumpur and Putrajaya, Malaysia, over six years from 2015 to 2020. Employing linear regression analysis, the study meticulously examines the relationship between property crime and various demographic factors, including total population, male and female populations, and residential and household densities. The findings indicate a consistent positive correlation between total population and property crime, emphasizing urban density's role in crime propensity. Notably, the male population shows a stronger correlation with property crime than females. The study also highlights how residential and household densities influence property crime in these urban settings. These insights are invaluable for policymakers and urban planners, guiding targeted strategies to reduce property crime in growing cities.
THE INFLUENCE OF TOURIST ATTRACTION POSITIONING ON TOURIST DECISIONS TO VISIT THE ‘XYZ’ IN SAMARINDA, INDONESIA
Authors: Dwiatmojo A Rinto , Kamarudin Khairul Hisyam , Nyura Yusni
Published: August 2024

To develop a good image, a tourist attraction must have good positioning so that it creates a positive impression and invite tourists to visit. This research aims to examine the influence of the positioning of a tourist attraction, consisting of experimental concept, price concept, and product attribute concept variables, on tourists' decisions to visit the "XYZ" tourist attraction in Samarinda. This quantitative study involved 100 tourist respondents who visited the "XYZ" tourist attraction in Samarinda, selected using non-probability purposive sampling technique. Data analysis in this research employed multiple linear regression. Data was processed using SPSS 27.00 for Windows. The results of the study show that the positioning of the tourist attraction consisting of experimental concept, price concept, and product attribute concept variables has a positive and significant impact on tourists' decisions to visit the "XYZ" tourist attraction in Samarinda. The product attribute concept variable is a dominant factor influencing tourists' decisions to visit the "XYZ" in Samarinda, with a coefficient value of 0.398, followed by the experimental concept variable with a coefficient value of 0.249, and the price concept variable with a coefficient value of 0.218.
COMMUNITY PARTICIPATION, COMMUNITY READINESS, AND PREFERENCES TO PROMOTE EDU-TOURISM IN MANGROVE AREAS OF TELUK AWUR VILLAGE, JEPARA, INDONESIA
Authors: Kurniati Rina , Handayani Wiwandari , Prabawani Bulan , Nida Rizqita Shofa , Savitri Salsabilla Fikha
Published: August 2024

Community readiness is a crucial element in tourism development, essential for the sustainability of mangrove edu-tourism. The development of mangrove edu-tourism can also provide co-benefits to the community. This study analyzes community readiness and preferences for involvement in edu-tourism development in Teluk Awur, Jepara, Indonesia. Quantitative methods with scoring techniques were used to assess community readiness based on sustainability indicators and criteria such as capacity building, participation, awareness of sustainability, and local resource utilization. The results indicate that community readiness scores are low, showing unpreparedness for edu-tourism development. This lack of readiness is attributed to insufficient capacity building and community participation. The study recommends educating the community about the co-benefits of mangrove edu-tourism to enhance their participation and capacity.
MODELLING STUDY ON CENTRAL COURTYARD SHADING STRATEGY IN TROPICAL CLIMATE REGION MALAYSIA
Authors: Khairuddin Nuur Liyana , Denan Zuraini
Published: August 2024

A courtyard is an open multi-functional space and an effective daylight passive design strategy in a building. However, to have a courtyard in a tropical country, it had to deal with the issue of visual discomfort, which requires some consideration in adaptation to the climate condition. These visual comfort issues include inconsistent light distribution, inappropriate illuminance levels, glare, and a lack of shaded areas. The focus of this research paper is to address the solution of shading strategies towards the visual discomfort issues associated with courtyard spaces. The solution is done by modelling study method on courtyard ratios and courtyard configuration to determine the effect on the internal courtyard percentage shaded area. This research aims to explore the potential benefits of using courtyards as a daylight shading design as a strategy in buildings. Besides, it is also to examine courtyard design variables in enhancing visual comfort, particularly in the context of commercial building design in Malaysia. Kuala Lumpur is chosen to represent the tropical climate region. The aim is achieved by identifying optimum courtyard ratios that can improve daylight, shading, and visual comfort that make courtyards functional and usable spaces. Results show that a small and deep courtyard is found to be best suited to tropical climate conditions with the configuration of the courtyard’s height being double the size or more than the size of the courtyard’s width. This courtyard ratio is able to produce a full shaded area during daytime. While courtyard length does not have any impact on the percentage of shaded area, wide and narrow courtyard need to adapt to the tropical climate constraint by having aided shading strategies such as multi-layered height of trees, independent covered structures like a canopy or gazebo, shading panels, awnings, and extended roof overhangs.
Grid-Connected Photovoltaic System for Generating Energy to Dairy Farm Activities
Authors: Steidle Neto Antonio José , Lopes Daniela de Carvalho
Published: August 2024

Minas Gerais is the leading milk-producing state in Brazil, and many dairy activities are supplied with electricity by the cable aerial network of the electrical energy state company. Given that the Brazilian energy matrix relies primarily on hydroelectric power, studies on the potential of other renewable energy sources in the context of dairy farms are innovative. Additionally, frequent disturbances and interruptions have motivated the installation of solar energy systems on dairy farms. However, the scarcity of technical and scientific studies demonstrating the benefits of electricity generated from photovoltaic panels in Minas Gerais has caused dairy farmers to fear potential financial losses. In this study, grid-connected photovoltaic systems in dairy farms were evaluated, considering three fixed tilt angles for the panels (latitude - 10°, latitude, and latitude + 10°) and electrical energy demands of dairy activities associated with two herd sizes (100 and 150 cows). Meteorological databases and mathematical models were used to predict daily global radiation on tilted panels in dairy farms of two Brazilian municipalities of Minas Gerais State (Lavras and Paracatu). Energy consumption related to dairy activities was monitored for 12 months. For both municipalities, the best results were verified with the tilt angle of panels equal to the local latitude - 10°. The municipality with the lowest latitude (Paracatu) showed higher electricity generation potential. In all simulated scenarios, a greater energy surplus was found from late spring to early autumn (Southern Hemisphere), when the higher electricity generation by the photovoltaic panels met the elevated electrical energy demand of the dairy farms. A high energy surplus was also verified during midwinter, where lower energy consumption by the dairy farms compensated for the reduced availability of solar radiation. The proposed methodology can be adapted to other dairy farms, agricultural and urban buildings.
Obtaining of WC–Co- and WC–TiC–Co-Based Ultradispersive Alloys Modified with B4C–TiB2 Quasieutetic
Authors: Tsagareishvili Otar , Mikeladze Archil , Chedia Roin , Batsikadze Tamaz , Chkhartishvili Levan
Published: August 2024

Tungsten carbide WC-based materials characterized by high hardness and wear resistance have long been widely used in manufacturing cutting and mining tools. They are alloyed or modified with different ceramic phases to improve operational characteristics further. There are obtained the hard tungsten carbide–cobalt WC–Co and tungsten carbide–titanium carbide–cobalt WC–TiC–Co metal-ceramic alloys ultradispersed powders modified with quasieutectic ceramic alloy B4C–30wt.%TiB2 and complex samples compacted from them. The quasieutectic alloy used as a modifier has almost as high hardness as pure boron carbide. Still, it is characterized by higher electrical and thermal conductivities of several orders of magnitude. Two groups of hard alloys modified with B4C–30wt.%TiB2 were studied: ВK8 grade WC–Co and T30K4 and T15K6 grades WC–TiC–Co. Metal-ceramic composite powders of different concentrations are obtained by chemical synthesis and mechanical dispersion in an attritor. The particle size of chemically synthesized composite powders is ≤0.3 μm, and those obtained by mechanical dispersion are ≤0.8 μm. SPS (Spark-Plasma Sintering) and HTS (High-Temperature Sintering) methods compact these powder materials. Phase composition of the obtained materials, distribution of chemical elements in them, and structural features are investigated by the XRD (X-Ray Diffraction) method and EDX (Energy Dispersive (micro)X-ray) spectrometry and optical and electron microscopies, respectively. Key physical-mechanical characteristics of the received samples, such as hardness, microhardness, and bending strength, are studied. Ultradispersed (≤0.8 μm) metal-ceramic alloys of the WC–Co–B4C–TiB2 system with interesting characteristics have been obtained using the WC–Co hard alloy of BK8 grade as the matrix. A SPS-compacted sample's hardness, microhardness, and bending strength are 93.0 HRA, 3350 kgf/mm2, and 100 kgf/mm2, respectively. Among the WC–TiC–Co system materials, the Т15K6 grade-based hard alloy modified with 15wt.%(B4C–30wt.%TiB2) has the best characteristics with hardness, microhardness, and bending strength of 91.5 HRA, 2900, and 117 kgf/mm2, respectively. A preliminary study of the problem of environmentally safe utilization of tungsten-containing scrap and tungsten waste is also carried out as part of the work. In particular, the tungsten heater waste is treated in hydrogen peroxide, and by adding specific liquid components to the tungsten-containing proper solution in a single utilization–synthesis cycle, the target product – ultradispersed WC–Co hard alloy is obtained.
Evaluation of a Natural Language Processing Approach to Identify Diagnostic Errors and Analysis of Safety Learning System Case Review Data: Retrospective Cohort Study
Authors: Tabaie Azade , Tran Alberta , Calabria Tony , Bennett Sonita S , Milicia Arianna , Weintraub William , Gallagher William James , Yosaitis John , Schubel Laura C , Hill Mary A , Smith Kelly Michelle , Miller Kristen
Published: August 2024

Background

Diagnostic errors are an underappreciated cause of preventable mortality in hospitals and pose a risk for severe patient harm and increase hospital length of stay.

Objective

This study aims to explore the potential of machine learning and natural language processing techniques in improving diagnostic safety surveillance. We conducted a rigorous evaluation of the feasibility and potential to use electronic health records clinical notes and existing case review data.

Methods

Safety Learning System case review data from 1 large health system composed of 10 hospitals in the mid-Atlantic region of the United States from February 2016 to September 2021 were analyzed. The case review outcome included opportunities for improvement including diagnostic opportunities for improvement. To supplement case review data, electronic health record clinical notes were extracted and analyzed. A simple logistic regression model along with 3 forms of logistic regression models (ie, Least Absolute Shrinkage and Selection Operator, Ridge, and Elastic Net) with regularization functions was trained on this data to compare classification performances in classifying patients who experienced diagnostic errors during hospitalization. Further, statistical tests were conducted to find significant differences between female and male patients who experienced diagnostic errors.

Results

In total, 126 (7.4%) patients (of 1704) had been identified by case reviewers as having experienced at least 1 diagnostic error. Patients who had experienced diagnostic error were grouped by sex: 59 (7.1%) of the 830 women and 67 (7.7%) of the 874 men. Among the patients who experienced a diagnostic error, female patients were older (median 72, IQR 66-80 vs median 67, IQR 57-76; P=.02), had higher rates of being admitted through general or internal medicine (69.5% vs 47.8%; P=.01), lower rates of cardiovascular-related admitted diagnosis (11.9% vs 28.4%; P=.02), and lower rates of being admitted through neurology department (2.3% vs 13.4%; P=.04). The Ridge model achieved the highest area under the receiver operating characteristic curve (0.885), specificity (0.797), positive predictive value (PPV; 0.24), and F1-score (0.369) in classifying patients who were at higher risk of diagnostic errors among hospitalized patients.

Conclusions

Our findings demonstrate that natural language processing can be a potential solution to more effectively identifying and selecting potential diagnostic error cases for review and therefore reducing the case review burden.
Comparative Bioavailability of Low-dose Micronized-isotretinoin 16 mg & Conventional Isotretinoin 20 mg Under Fasting Condition in Healthy Adult Male Subjects: A Randomized, Single-dose, Two-way, Cross-over Study (Preprint)
Authors: Madan Sumit , Kumar Sudershan , Mehra Sachin , Shah Priyank , Gabhane Mukesh , Dharmadhikari Shruti
Published: August 2024

BACKGROUND

Isotretinoin, the first line therapy for the treatment of severe nodular acne, is recommended to be administered with meals to optimize its bioavailability and efficacy. To overcome this limitation, low-dose micronized-isotretinoin is formulated by using an optimized micronization technology that enhances the rate of dissolution and bioavailability of isotretinoin.

OBJECTIVE

To assess the comparative bioavailability of low-dose micronized-isotretinoin 16mg (Test;T) and conventional isotretinoin 20mg (Reference;R) under fasting condition.

METHODS

An open label, randomized, two-treatment, two-period, two-sequence, single-dose, cross-over comparative bioavailability study. Study period involved fasting for at least 10hours prior to administration and 4hours after a single oral dose of either test or reference product. The interval between dosing (washout period) was 18days.

RESULTS

Total 15 participants completed the study. The Cmax was 439.58±169.99ng/mL and 149.64±26.91ng/mL; and AUC0–∞ was 6181.90 ± 2240.75ng·h/mL and 2479.83 ± 975.90ng·h/mL for test and reference, respectively. The ratio of T/R [90 %CI] were 277.78% (238.11-324.06) for Cmax, and 246.95% (228.93-266.39) for AUC0–∞. The Median Tmax was 3.25hrs and 2.75hrs test and reference formulation respectively. Both the formulations were well tolerated.

CONCLUSIONS

Low-dose micronized-isotretinoin 16mg had ~2.5 folds higher bioavailability as compared to conventional isotretinoin 20mg under fasting conditions.
Impact of virtual reality-based biofeedback on sleep quality among individuals with depression and anxiety: a 4-week randomized controlled study (Preprint)
Authors: Jeon Hong Jin , Seong Sisu , Kim Hyewon , Cho Yaehee , Kim Min-Ji , Park Ka Ram , Choi Jooeun , Lee Seonah , Kim Dong Jun , Kim Seog Ju
Published: August 2024

BACKGROUND

Depressive disorders, projected by the WHO to rank third in global disease burden by 2030, significantly impair quality of life, with over 300 million affected worldwide. Sleep difficulties, particularly insomnia, are closely linked to depression, exacerbating its severity. Biofeedback (BF) therapy, specifically heart rate variability biofeedback (HRV-BF), shows promise in treating insomnia and associated depressive symptoms. Recent studies suggest that integrating virtual reality (VR) into BF therapy could enhance its efficacy by creating immersive, calming environments that improve sleep quality. This study explores the potential of VR-based BF to improve sleep in individuals with depression and anxiety.

OBJECTIVE

To investigate impact of virtual reality-based biofeedback (VR-based BF) on sleep quality as measured by the Pittsburgh Sleep Quality Index (PSQI) of individuals with depressive or anxiety symptoms.

METHODS

Between December 2019 and February 2022, 131 adult volunteers were recruited at Samsung Medical Center, Seoul, South Korea. Individuals with specific medical or psychiatric conditions were excluded. Those with depressive and anxiety symptoms (DAS) were randomized into VR (n = 40) and BF (n = 38) groups by computer-generated random number. A Healthy Control (HC, n = 40) cohort with sham intervention mirroring the DAS/VR group was also included. Over three visits, participants received VR-based BF or conventional BF with a therapist. Iterative baseline and 4-week follow-up PSQI assessments were performed. Following intervention, subcomponent scores of the PSQI decreased in both DAS/VR and DAS/BF groups.

RESULTS

After 4-week intervention, a decrease in global PSQI scores was observed across all groups. For Global PSQI score, the DAS/VR group demonstrated a substantial reduction from 9.70 (±2.49) to 7.20 (±2.46) (p<0.001), and the HC/VR group from 5.85 (±2.39) to 4.90 (±2.11) (p=0.007). Notably, improvements in sleep quality, latency, disturbance, and day dysfunction were statistically significant in the DAS/VR groups but not in sleep duration, efficiency, and sleep medicine uses.

CONCLUSIONS

This study provides evidence that VR-based BF can serve as effective psychological intervention for enhancing sleep quality of individuals experiencing symptoms of depression and anxiety, and also effective in health subjects.
C-reactive protein (CRP) and lactate dehydrogenase (LDH) as functional outcome predictors in stroke patients
Authors: Nadhilla Nyimas Farisa , Gofir Abdul , Setyawan Tommy Rachmat , Farida Siti , Ar Rochmah Mawaddah
Published: August 2024

Stroke is a neurologic disorder with high mortality and disability. Its pathophysiology is associated with vascular inflammation. However, studies between vascular inflammatory markers and stroke outcomes are still limited. This study aimed to investigate the association between inflammatory markers and functional outcomes of stroke. This was a retrospective cohort study involving all stroke patients at the Dr. Sardjito General Hospital, Yogyakarta from October 2020 to August 2021 who meet the inclusion and exclusion criteria. Mann-Whitney was used for bivariate analysis, followed by multivariate analysis. A total of 269 subjects, with 213 infarcts (79.2%) and 56 hemorrhagic (20.8%) strokes. There were 83 subjects deceased (30.9%), with 66 infarct (31%) and 17 hemorrhagic (30.4%) strokes. High CRP levels had significant and independent associations with worse GCS, ADL, IADL, NIHSS, BI, SSGM, MRS, and higher mortality rates (p < 0.05). High LDH levels had a significant and independent association with worse GCS scores and higher mortality rates (p < 0.05). Sub-analysis showed high CRP and LDH had associations with high mortality rates in infarct (p < 0.001), but only CRP (p = 0.029) had associations with high mortality rates in hemorrhagic. There was no significant association between fibrinogen and procalcitonin with stroke outcomes (p > 0.05). Cox-regression analysis showed CRP>24.5 mg/dL and LDH >300U/L associated with hazard ratios of 3.2 (p < 0.001) and 1.65 (p = 0.026). In conclusion. high CRP and LDH levels are associated with mortality rates in stroke patients.
Juvenile ossifying fibroma accompanied with low-grade central osteosarcoma in sinonasal: a rare case report
Authors: Solichin Muchamad Ridotu , Hakim Fikar Arsyad , Dwianingsih Ery Kus
Published: August 2024

Sinonasal osteosarcoma is comparatively rare and accounts for 6.5% of all osteosarcomas. The five-year survival rate is less than 25% and may be improved to 60% when chemotherapy is initiated earlier. The diagnosis of low-grade central osteosarcoma requires a meticulous histopathological examination because histopathologically the tumor may mimic fibro-osseus neoplasm. We report a 12 y.o. male patient who complained of a lump on the face for 4 yr with symptoms of nasal discharge, congestion, epistaxis, and a feeling of fullness in the ears. Sinonasal biopsy was later performed and revealed an inverted papilloma. Two months after the biopsy procedure, mass extirpation and medial maxillectomy were performed. Histopathology examination confirms the diagnosis of ossifying fibroma accompanied by low-grade central osteosarcoma. Low-grade central osteosarcoma is an exceptionally rare variant, and the diagnosis is occasionally difficult. It can be misdiagnosed as a benign lesion, especially fibrous dysplasia or ossifying fibroma. Histomorphological, the discovery of atypical tumor cells producing osteoid matrix can be used to confirm that the lesion is a malignant lesion of low-grade central osteosarcoma. As demonstrated in our case, the tumor can consist of a trabecular and curvilinear arrangement of immature bone, at the edges of which there is an osteoblastic rimming appearance with a background of connective tissue stroma which is a histopathological feature of ossifying fibroma.
Autoimmune manifestation in splenic atrophy presented with toxic shock syndrome: a case report
Authors: Liang Song Zhi , Han Poh Yeh , Singam Gaithridevi V , Yong Tan Sue , Thomson Koo , Adlihafizi Ab Aziz  , Lim Shiao Hui  , Kuai Chen Chuan  , Ong Lay Sim  , Lim Chew Har
Published: August 2024

Splenic atrophy is an uncommon diagnosis, associated with autoimmune gastrointestinal disorders and other well-characterized connective tissue diseases. We would like to contribute a case report to support the association evidence of the real-world data. To our best knowledge, there is no similar case of splenic atrophy with the presentation of streptococcal toxic shock syndrome reported. Our patient was initially detected with atrophic spleen via CT scan and subsequently diagnosed with systemic sclerosis. Hyposplenism should be suspected in patients with adult-onset infections caused by encapsulated bacteria, especially if autoantibodies are present. Our patient received her pneumococcal vaccination before discharge and was followed in the clinic for further vaccination education and health check-up. Learning points: 1) Acquired splenic atrophy is a rare condition that may be suspected from persistent isolated thrombocytosis after the resolution of sepsis and Howell-Jolly bodies from peripheral blood film; 2) The pathophysiological mechanism of splenic atrophy in the context of autoimmune disorders remains unknown; 3) A high index of suspicion towards the evaluation of splenic function is required if a patient presented with community-acquired encapsulated organism bacteraemia; 4) Vaccination against encapsulated bacterial agents should be performed in patients with hyposplenism.
EGFR mutation based on lung laterality in adenocarcinoma type of non-small cell lung cancer
Authors: Ryan Feraldy Haroen  , Paranita Ferronika  , Rita Cempaka  , Indrawati  , Bening Rahimi Titisari  , Vincent Lau  , Andrew Nobiantoro Gunawan  , Brigitta Natasya Halim  , Vincent Laiman  , Lina Choridah  , Didik Setyo Heriyanto
Published: August 2024

Targeted therapies have shown promise in improving survival rates for lung adenocarcinoma, a common and deadly malignancy. EGFR-targeting tyrosine kinase inhibitors (TKIs) are particularly effective among these therapies in cases with EGFR mutations. Detecting these mutations before TKI treatment is essential. Various radiological features have been linked to EGFR mutations. However, the relationship between tumor location and mutation types in Indonesian lung adenocarcinoma patients remains unexplored. This study aimed to identify the frequency of EGFR mutation in local lung adenocarcinoma cases based on the tumor location. Clinical data of lung adenocarcinoma patients (n = 272) diagnosed between 2018 and 2022 were retrospectively taken from the Department of Anatomical Pathology, Dr. Sardjito General Hospital, Yogyakarta. The qRT-PCR data of EGFR mutation status was obtained from the Department of Anatomical Pathology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta. Descriptive analysis was performed using STATA version 14.0. EGFR mutations were found in 60.7% of patients, with 58.2% having exon 19 mutations and 21.2% exhibiting exon 21 L858R mutations. Mutation status was found to be significantly different based on the patient's gender (p = 0.022) and age (p = 0.029) but not with lung laterality (p = 0.093). The proportion of exon 19, exon 21 L858R, and uncommon mutations in the right and left lung adenocarcinoma was similar across all samples. This study found no difference between specific EGFR mutation types and tumor location in lung adenocarcinoma.
Analytical Analysis of Buckling Of Layered Composite Columns
Authors: Patil Mr. Mayuresh
Published: August 2024

Abstract: Lightweight composite construction is of great interest in the design and manufacture of spacecraft and marine vehicles because of high specific stiffness and strength. In addition, sandwich construction offers enhanced corrosion resistance, noise suppression and reduction in life-cycle costs. There are several issues and questions related to the use of composite construction that require attention and answers. One of the important issues is the prediction of buckling loads, under either static or sudden load application. For the static case, closed form solutions are derived for a symmetric composite column under axial compression and for various boundary conditions. In this study, improved analytical models are developed to characterize interface behavior of layered composite column-type structures. The mechanics models of the bonded interface with and without adhesive layer are established, from which the interface fracture, delamination buckling, free vibration and stress analysis across the adhesive layer of corresponding interface are studied.
Analysis of Genetic Variability and Heritability of Agronomic Characters from Crossing Yardlong Bean of Fagiola IPB x Super Putih
Authors: Bakhtiar Ikrima Farishani , Anwar Syaiful , Kusmiyati Florentina
Published: August 2024

This research aim was to estimate the variability value and heritability of quantitative and qualitative character on F4 generation from crossing Fagiola IPB and Super Putih. The observed parameters were plant height, number of leaves, number of branches, the day of flowering, length of young pod, pod color, number of pod, number of seeds, seed weight, weight of one seed, weight of 100 seeds, and sweetness. Data were analized by Analysis of Variance, Genetic Variability, and Heritability. The result showed that only character of seed weight per plant had high genetic variability. The characters of number of leaves, number of branches, length of young pods, number of old pods, number of seeds, weight of seeds, one seed weight, and weight of 100 seeds had high heritability. The day of flowering and sweetness had low heritability. The results of the dendogram analysis showed that group C was recommended for next generations.
Biological Agent’s Effectiveness For Control Of Diamondback Moth Larvae (Plutella xylostella Linn) With Different Population Levels On Lettuce
Authors: Mumtahanah Zulfa Naila , Kristanto Budi , Kusmiyati Florentina
Published: August 2024

Tritip caterpillars (Plutella xylostella) are pests that cause damage and reduce lettuce production. Control of P. xylostella pests can be done using biological agents or synthetic insecticides. Synthetic chemical pesticides in the long term can be used for resistance and resurgence of pests. Biological agents of B. bassiana, Metarhizium sp., and Trichoderma sp. can be used as an alternative solution to controlling P. xylostella. Research to examine the use of biological agents using B. bassiana, Metarhizium sp. and Trichoderma sp. to control P. xylostella attacks at different levels of pest participation. The study was conducted from 19 September to 9 November 2018 in Sidomukti, Bandungan, Semarang. The study used a completely randomized 5x3 split-plot pattern design with 3 replications. The main plot is the type of biological agents: A1: B. bassiana, A2: Metarhizium sp., A3: Trichoderma sp., A4: Insecticide and A5: control. The subplot is the pest population level: B1 = 1 larvae/plant, B2 = 2 larvae/plant, and B3 = 3 larvae/plant. Data were analyzed using ANOVA and continued with Duncan's Multiple Range Test. The results showed that biological agents and insecticides increased pest mortality, the percentage of healthy leaves, decreased the percentage of damaged leaves, the level of pest defense, and reduced the yield of lettuce.
Evaluation of Genetic diversity and Heritability on Soybeans Agronomic Characters in M4 by Gamma Irradiation
Authors: Sari Yunita Mahda , Kusmiyati Florentina , Anwar Syaiful
Published: August 2024

The production of soybeans can be increase by breeding for tolerance soybeans at saline soil. Mutation by gamma rays is one of a breeding technique that can be modifiy plant's genetic. The soybeans that used was induced by gamma rays with dosis 160 Gy, 208 Gy, 256 Gy, 352 Gy, and 400 Gy. The research objective was to evaluate the genetic variability and heritability for some characters of M4 soybean mutations resulting from gamma irradiation mutations.The material used consisted of 18 genotypes of M4. This research was conducted at Agrotechopark, Faculty of Animal and Agricultural Science, Diponegoro University from July to November 2019. The experimental was arranged in a completely randomized design (CDR) monofactor with 18 genotypes of black soybeans and Detam-3 Prida as controls. The results showed that genetic diversity observed in the overall character of plants except flowering age, number of empty pods, weight of one seed, and weight of 100 grains. The result of heritability showed a high heritability on the parameters of plant height, age of harvest, total number of seeds, number of filled pods, total number of pods, total pod weight, and total seed weight. The value of moderate heritability is found on the parameters of the number of leaves, and then the low heritability is on the parameters of flowering age, number of empty pods, weight of 1 seed, and weight of 100 grains.
The Effect Of The Administration Of Calcium Chloride (CaCl2) And Phosphoric Acid Fertilizer (H3PO4) On The Growth And Production Of Strawberry (Fragaria ananassa)
Authors: Rasyid Harun , Zakia Aulia , Triyuana Resty Mirza
Published: August 2024

Strawberry production in Indonesia has been on the rise in various regions, including Aceh, Riau, Jambi, DKI Jakarta, West Java, Central Java, East Java, and others. According to the Central Bureau of Statistics (2021), production fluctuated from 573.00 tons in 2019 to 559.00 tons in 2020, rebounding to 838.00 tons in 2021. Factors influencing production include land availability, proper fertilization methods, and planting media. Adequate fertilization, considering both dosage and frequency, plays a crucial role. The study, conducted at Balitjestro GreenHouse in Batu City, East Java, focused on the interaction between lime and fertilizer on strawberry plant growth and yield. Synthetic fertilizers, particularly phosphate fertilizers, are essential for plant growth. The research utilized a completely randomized design with two factors: CaCl2 lime (S) and phosphoric acid fertilizer (R), resulting in two treatment combinations (4x4). Each treatment, repeated three times, yielded 48 experimental units, with one plant per unit. Results indicated that the addition of CaCl2 lime and phosphoric acid fertilizer had a minimal impact on strawberry plant growth and production. Specific combinations, such as calcium chloride and phosphoric acid fertilizer with KCL 7.2 grams and urea 12.5 grams, did not significantly affect vegetative growth parameters like plant height and leaf count. However, these combinations did influence strawberry plant production. The study underscores the need for careful nutrient management to optimize strawberry production in Indonesia.
Application Of Dosege And Interval Of Fertilizer On Kale (Brassica oleracea var. Acephala)
Authors: Praciska Intan Okta , Zainudin Agus , Septia Erfan Dani
Published: August 2024

The research aimed to explore the impact of vermicompost fertilizer dosage and application timing on kale (Brassica oleracea var. Acephala) varieties. Conducted in Sukoharjo Village from July to September 2020, the study implemented a Randomized Complete Block Design with two factors: vermicompost dosage (D0: NPK 2 g/plant/untreated, D1: 250 g/plant, D2: 500 g/plant, D3: 750 g/plant) and application time (T1: planting, T2: 7 days after planting, T3: 14 days after planting). Analysis revealed no interaction between dosage and application time. Doses of 250 g (D1), 500 g (D2), and 750 g (D3) significantly differed in plant height, leaf number, stem diameter, leaf area, and fresh and dry weights. Notably, the application time at planting (T1), 7 days after planting (T2), and 14 days after planting (T3) significantly affected leaf number. In conclusion, the study found no interaction effect between vermicompost dosage and application time on kale. Doses of 250 g, 500 g, and 750 g exhibited significant differences, impacting plant growth and dry weight. Application times at planting, 7 days after planting, and 14 days after planting significantly influenced leaf number. These findings emphasize the importance of proper dosage and timing for optimizing kale growth with vermicompost fertilizer, contributing to sustainable agricultural practices.
Test The Effectiveness Volume Of Hydroton Media On Mustard Plant (Brassica Chinensis Var. Parachinensis) Using Auto Kapiler
Authors: Septia Erfan Dani , Maftuchah  , Nurfutika Mifta
Published: August 2024

This study aims to determine the level of effectiveness the hydroton growing media on mustard plants using the Auto Kapiler hydroponic method with 3 treatments; M1 with hydroton growing media of 2,54 liters (volume 50%), M2 with hydroton growing media of 3,78 liters (75% volume), and M3 with hydroton growing media of 5,04 liters (100% volume). The research was conducted on Jl. Tirtonadi RT. 25 / RW. 04, Jatikerto village, Kromengan sub-district, Malang district which will take place from April 25 to June 14, 2022. Some of the materials and tools used during the research are; hydroton growing media, auto capillary, AB-Mix nutrition, pH meter, and EC meter. Variable observations made consist of; plant height (cm), number of leaves (strands), leaf width (cm), root length (cm), and plant fresh weight (grams). Data analysis in this study used a simple Completely Randomized Design (CRD) with 4 replications and 3 treatments. The data obtained were further analyzed using the least significant Least Significant Different (LSD) α 5% level which was then further analyzed using a linear regression. The results showed that the M3 treatment (100% hydroton growing media volume was 5,04 liters) was better than the M2 treatment (75% hydroton growing media volume 3,78 liters) and M1 (50% hydroton growing media volume 2,52 liter).