bluuebunny/crossref_metadata_2025 huggingface dataset:
Numerical and Experimental Studies on Crack Resistance of Ultra-High-Performance Concrete Decorative Panels for Bridges
Authors: Zhao Jiongfeng , Zhang Yang , Qin Yanyue
Published: January 2024

This study develops a new type of decorative bridge panel by ultra-high-performance concrete (UHPC) based on the project of the Guangyangwan Bridge. First, the numerical analysis was carried out using MIDAS and ABAQUS to find the critical position of the bridge and decorative panels. The numerical results showed that the last concrete cantilever segment had the greatest vertical deflection, and the corresponding panel had the greatest stress response. Based on the numerical results, this study conducted a series of full-scale, self-balanced bending tests to examine the crack resistance of six UHPC panels and six glass fiber-reinforced concrete (GRC) panels with varying curved section thicknesses (from 25 to 40 mm). The experimental results indicate that, due to the high strength of the UHPC matrix and the wall effect of steel fiber distribution, the crack resistance of UHPC panels is significantly superior to that of GRC panels. UHPC panels possessed superior stiffness and ductility, while GRC panels showed brittle fracture when the curved section thickness reached 34 mm. The uniaxial tensile cracking strength of UHPC with a steel fiber volume fraction of 1.6% was 14.7% greater than that of GRC with a glass fiber volume fraction of 5%. At the same curved section thicknesses, UHPC decorative panels exhibit cracking loads and ultimate loads that are 64.3% to 123.0% and 29.2% to 115.0% greater than GRC panels, respectively. Hence, UHPC is more suitable to produce ultra-thin decorative panels for bridges that are subjected to severe environmental action and external forces.
Human Factors as Predictor of Fatalities in Aviation Accidents: A Neural Network Analysis
Authors: Lázaro Flávio L. , Nogueira Rui P. R. , Melicio Rui , Valério Duarte , Santos Luís F. F. M.
Published: January 2024

In the area of aviation safety, the importance of human factors is indisputable. This research endeavors to assess the importance of human factors in predicting fatalities during aviation mishaps. Utilizing reports from the Aviation Safety Network Database, encompassing 1105 accidents and incidents spanning from 2007 to 2016, neural networks were trained to forecast the probability of fatalities. Our findings underscore that the human factors involved, by themselves, can yield strong predictions. As a term of comparison, other variables (type of occurrence, flight phase, and aircraft fate) were used as predictors, with poorer results; by combining these variables with human factors, the prediction is only marginally better, if at all, than that based on human factors alone. So, although these supplementary variables can marginally benefit the predictive results derived from human factors, their contribution remains minimal. Consequently, this study illuminates the paramount importance of human factors in influencing aviation fatalities, guiding stakeholders on the immediate interventions and investments which are most warranted to prevent them.
The Western Artist in Stalin’s Moscow: The Case of Albin Amelin
Authors: Lopatkina Katarina
Published: January 2024

This article is a reconstruction of travel experiences of Swedish artist Albin Amelin in Moscow in 1937–1938, based on archival materials. It focuses on the exchange between the Soviet Union and Western artists in the interwar period and shows international Soviet art contacts as part of the state’s diplomatic work. This case study enables a detailed observation of the elements of the Soviet hospitality industry, and a description of various practical aspects of the artist’s stay in Moscow.
How to Choreograph a Socialist Society?
Authors: Petkovski Filip
Published: January 2024

During the existence of Yugoslavia (1945–1991), the leading political ideology of “brotherhood and unity” had to be manifested in all forms of cultural life. Promoting the physically capable body as part of a larger cultural movement, Yugoslavia witnessed the transformation of physical daily regimens into mass bodily spectacles performed at stadiums, called sletovi, demonstrating the power of mass-choreographed discipline. Similarly, Yugoslav choreographers were encouraged to develop a distinct performance aesthetic based on stylization as a rhetoric for modernization, using folk dance as a medium to showcase and promote the collective body of the people through choreographed folklore spectacles. Focusing on these two case studies that exemplify how mass choreography was used as a strategy to choreograph the Yugoslav society, this paper analyzes how political ideologies and their constructions through physicality supported the Yugoslav state project, thereby pointing to the present-day remnants of these aesthetics in the post-Yugoslav republics, evident in mass protests. By utilizing archival and choreographic analysis, I demonstrate how movement and dance impacted the public understanding of unity and helped the creation of a Yugoslav socialist society, drawing from Andrew Hewitt’s thesis on “social choreography”.
The ‘Assetization’ of Art on an Institutional Level—Fractional Ownership Implemented in the Royal Museum of Fine Arts Antwerp
Authors: Kalbermatten Syra
Published: January 2024

This article explores the innovative collaboration between the Rubey platform and the Royal Museum of Fine Arts, Antwerp. Through the tokenization of the artwork Carnaval de Binche by James Ensor, this platform made it possible for interested investors to purchase blockchain-registered Art Security Tokens within this artwork and become co-owners of it—at least from an economic perspective. Although fractional ownership platforms for art have been established before, this is the first time an art investment opportunity like this has materialized itself in an explicit partnership with a museum. The tokenized artwork will be held on public display within the Royal Museum of Fine Arts Antwerp, for a period of ten years—a significant departure from the usual practice of storing such pieces in a storage vault—before it will be sold again. This article contextualizes this practice within both the ‘assetization’ of art that has increased in recent decades and the financial challenges facing Belgian—more broadly speaking, European—public museums. Based on a limited number of interviews with the stakeholders and desk research, this article subsequently explores the more practical benefits and concerns of a collaboration like this and presents an analysis of this practice drawing upon publications within the field of economic sociology. Since we find ourselves only at the beginning of this partnership, some questions will be raised for further research.
A Method for the Ambient Equivalent Dose Estimation in a Wide Range of Altitudes during SEP and GLE Events
Authors: Maurchev Eugene , Shlyk Nataly , Abunina Maria , Abunin Artem , Belov Anatoly , Didenko Kseniia
Published: January 2024

The paper considers the modeling of proton transport through the Earth’s atmosphere during several SEP events (12 August 1989, 23 March 1991, and 8 November 2000), as well as during the GLE73 event. Solar sources and interplanetary medium conditions during these events are described in detail. Calculations are carried out using own model implemented with GEANT4. As the main results, quantitative estimates of the calculated ambient dose equivalent for altitudes in a wide range (also including civil aircraft flight altitudes of 10–11 km) for the geomagnetic cutoff rigidity values Rc = 0.13 GV are given.
Evaluation of Daily Temperature Extremes in the ECMWF Operational Weather Forecasts and ERA5 Reanalysis
Authors: Lopes Francisco M. , Dutra Emanuel , Boussetta Souhail
Published: January 2024

In weather forecasting and climate monitoring, daily maximum and minimum air temperatures (TMAX and TMIN) are fundamental for operational and research purposes, from early warning of extreme events to climate change studies. This study provides an integrated evaluation of TMAX and TMIN from two European Centre for Medium-range Weather Forecasts (ECMWF) products: ERA5 reanalysis (1980–2019) and operational weather forecasts (2017–2021). Both products are evaluated using in situ observations from the Global Historical Climatology Network (GHCN). While the analyses span globally, emphasis is given to four key regions: Europe, East and West United States, and Australia. Results reveal a general underestimation of TMAX and overestimation of TMIN in both operational forecasts and ERA5, highlighting the limitation of the ECMWF model in estimating the amplitude of the diurnal cycle of air temperature. ERA5′s accuracy has improved over the past decade, due to enhanced constrain of land–atmosphere analysis streaming from more and higher-quality satellite data. Furthermore, ERA5 outperforms one-day-ahead weather forecasts, indicating that non-real-time dependent studies should rely on ERA5 instead of real-time operational forecasts. This study underscores the importance of ongoing research in model and data assimilation, considering the relevance of daily temperature extremes forecasting and reanalysis for operational meteorology and climate monitoring.
Effect of Heating Emissions on the Fractal Size Distribution of Atmospheric Particle Concentrations
Authors: Norbu Namkha , Sheng Xiaolei , Liu Qiang , Han Haihui , Zhang Xin
Published: January 2024

Excessive particle concentrations during heating periods, which greatly affect people’s physical and mental health and their normal lives, continue to be a concern. It is more practical to understand and analyze the relationship between the fractal dimension and particle size concentration distribution of atmospheric particulate matter before and after adjusting heating energy consumption types. The data discussed and analyzed in this paper were collected by monitoring stations and measured from 2016 to 2018 in Xi’an. The data include fractal dimension and particle size concentration changes in the atmospheric particulate matter before and after adjusting the heating energy consumption types. The results indicate that adjusting the heating energy consumption types has a significant impact on particulate matter. The average concentration of PM2.5 decreased by 26.4 μg/m3. The average concentration of PM10 decreased by 31.8 μg/m3. At the same time, the different particle sizes showed a downward trend. The particles ranging from 0.265 to 0.475 μm demonstrated the maximum decrease, which was 8.80%. The heating period in Xi’an mainly involves particles ranging from 0 to 0.475 μm. The fractal dimensions of the atmospheric particulate matter before and after adjusting the heating energy consumption types were 4.809 and 3.397, respectively. After adjusting the heating energy consumption types, the fractal dimension decreased by 1.412. At that time, the proportions of particle sizes that were less than 1.0 μm, 2.0 μm, and 2.5 μm decreased by 1.467%, 0.604%, and 0.424%, respectively. This paper provides new methods and a reference value for the distribution and effective control of atmospheric particulate matter by adjusting heating energy consumption types.
A Note on the Time-Fractional Navier–Stokes Equation and the Double Sumudu-Generalized Laplace Transform Decomposition Method
Authors: Eltayeb Hassan , Bachar Imed , Mesloub Said
Published: January 2024

In this work, the time-fractional Navier–Stokes equation is discussed using a calculational method, which is called the Sumudu-generalized Laplace transform decomposition method (DGLTDM). The fractional derivatives are defined in the Caputo sense. The (DGLTDM) is a hybrid of the Sumudu-generalized Laplace transform and the decomposition method. Three examples of the time-fractional Navier–Stokes equation are studied to check the validity and demonstrate the effectiveness of the current method. The results show that the suggested method succeeds remarkably well in terms of proficiency and can be utilized to study more problems in the field of nonlinear fractional differential equations (FDEs).
Special Issue “Optimisation Models and Applications”
Authors: Pedrammehr Siamak , Qazani Mohammad Reza Chalak
Published: January 2024

Optimisation models have transcended their origins to become indispensable tools across many fields, including engineering, economics, the environment, health, systems of systems, businesses, and beyond [...]
An Overview of the Sustainable Recycling Processes Used for Lithium-Ion Batteries
Authors: Marchese Daniele , Giosuè Chiara , Staffolani Antunes , Conti Massimo , Orcioni Simone , Soavi Francesca , Cavalletti Matteo , Stipa Pierluigi
Published: January 2024

Lithium-ion batteries (LIBs) can play a crucial role in the decarbonization process that is being tackled worldwide; millions of electric vehicles are already provided with or are directly powered by LIBs, and a large number of them will flood the markets within the next 8–10 years. Proper disposal strategies are required, and sustainable and environmental impacts need to be considered. Despite still finding little applicability in the industrial field, recycling could become one of the most sustainable options to handle the end of life of LIBs. This review reports on the most recent advances in sustainable processing for spent LIB recycling that is needed to improve the LIB value chain, with a special focus on green leaching technologies for Co-based cathodes. Specifically, we provide the main state of the art for sustainable LIB recycling processes, focusing on the pretreatment of spent LIBs; we report on Life Cycle Assessment (LCA) studies on the usage of acids, including mineral as well as organic ones; and summarize the recent innovation for the green recovery of valuable metals from spent LIBs, including electrochemical methods. The advantage of using green leaching agents, such as organic acids, which represent a valuable option towards more sustainable recycling processes, is also discussed. Organic acids can, indeed, reduce the economic, chemical, and environmental impacts of LIBs since post-treatments are avoided. Furthermore, existing challenges are identified herein, and suggestions for improving the effectiveness of recycling are defined.
Multi-Dimensional Modeling of Cerebral Hemodynamics: A Systematic Review
Authors: Korte Jana , Klopp Ehlar Sophie , Berg Philipp
Published: January 2024

The Circle of Willis (CoW) describes the arterial system in the human brain enabling the neurovascular blood supply. Neurovascular diseases like intracranial aneurysms (IAs) can occur within the CoW and carry the risk of rupture, which can lead to subarachnoid hemorrhage. The assessment of hemodynamic information in these pathologies is crucial for their understanding regarding detection, diagnosis and treatment. Multi-dimensional in silico approaches exist to evaluate these hemodynamics based on patient-specific input data. The approaches comprise low-scale (zero-dimensional, one-dimensional) and high-scale (three-dimensional) models as well as multi-scale coupled models. The input data can be derived from medical imaging, numerical models, literature-based assumptions or from measurements within healthy subjects. Thus, the most realistic description of neurovascular hemodynamics is still controversial. Within this systematic review, first, the models of the three scales (0D, 1D, 3D) and second, the multi-scale models, which are coupled versions of the three scales, were discussed. Current best practices in describing neurovascular hemodynamics most realistically and their clinical applicablility were elucidated. The performance of 3D simulation entails high computational expenses, which could be reduced by analyzing solely the region of interest in detail. Medical imaging to establish patient-specific boundary conditions is usually rare, and thus, lower dimensional models provide a realistic mimicking of the surrounding hemodynamics. Multi-scale coupling, however, is computationally expensive as well, especially when taking all dimensions into account. In conclusion, the 0D–1D–3D multi-scale approach provides the most realistic outcome; nevertheless, it is least applicable. A 1D–3D multi-scale model can be considered regarding a beneficial trade-off between realistic results and applicable performance.
Are MTV and TLG Accurate for Quantifying the Intensity of Brown Adipose Tissue Activation?
Authors: Jalloul Wael , Moscalu Mihaela , Moscalu Roxana , Jalloul Despina , Grierosu Irena Cristina , Gutu Mihaela , Haba Danisia , Mocanu Veronica , Gutu Mihai Marius , Stefanescu Cipriana
Published: January 2024

Recent research has suggested that one novel mechanism of action for anti-obesity medications is to stimulate the activation of brown adipose tissue (BAT). 18FDG PET/CT remains the gold standard for defining and quantifying BAT. SUVmax is the most often used quantification tool in clinical practice. However, this parameter does not reflect the entire BAT volume. As a potential method for precisely evaluating BAT, we have utilised metabolic tumour volume (MTV) and total lesion glycolysis (TLG) to answer the question: Are MTV and TLG accurate in quantifying the intensity of BAT activation? After analysing the total number of oncological 18F-FDG PET/CT scans between 2021–2023, we selected patients with active BAT. Based on the BAT SUVmax, the patients were divided into BAT-moderate activation (MA) vs. BAT-high activation (HA). Furthermore, we statistically analysed the accuracy of TLG and MTV in assessing BAT activation intensity. The results showed that both parameters increased their predictive value regarding BAT activation, and presented a significantly high sensitivity and specificity for the correct classification of BAT activation intensity. To conclude, these parameters could be important indicators with increased accuracy for classifying BAT expression, and could bring additional information about the volume of BAT to complement the limitations of the SUVmax.
Bielectrode Strategy for Determination of CYP2E1 Catalytic Activity: Electrodes with Bactosomes and Voltammetric Determination of 6-Hydroxychlorzoxazone
Authors: Kuzikov Alexey V. , Masamrekh Rami A. , Filippova Tatiana A. , Tumilovich Anastasiya M. , Strushkevich Natallia V. , Gilep Andrei A. , Khudoklinova Yulia Yu. , Shumyantseva Victoria V.
Published: January 2024

We describe a bielectrode system for evaluation of the electrocatalytic activity of cytochrome P450 2E1 (CYP2E1) towards chlorzoxazone. One electrode of the system was employed to immobilize Bactosomes with human CYP2E1, cytochrome P450 reductase (CPR), and cytochrome b5 (cyt b5). The second electrode was used to quantify CYP2E1-produced 6-hydroxychlorzoxazone by its direct electrochemical oxidation, registered using square-wave voltammetry. Using this system, we determined the steady-state kinetic parameters of chlorzoxazone hydroxylation by CYP2E1 of Bactosomes immobilized on the electrode: the maximal reaction rate (Vmax) was 1.64 ± 0.08 min−1, and the Michaelis constant (KM) was 78 ± 9 μM. We studied the electrochemical characteristics of immobilized Bactosomes and have revealed that electron transfer from the electrode occurs both to the flavin prosthetic groups of CPR and the heme iron ions of CYP2E1 and cyt b5. Additionally, it has been demonstrated that CPR has the capacity to activate CYP2E1 electrocatalytic activity towards chlorzoxazone, likely through intermolecular electron transfer from the electrochemically reduced form of CPR to the CYP2E1 heme iron ion.
Inflammation and Fibrosis in Sleep-Disordered Breathing after Acute Myocardial Infarction
Authors: Pec Jan , Buchner Stefan , Fox Henrik , Oldenburg Olaf , Stadler Stefan , Maier Lars S. , Arzt Michael , Wagner Stefan
Published: January 2024

Background: After acute myocardial infarction (AMI), inflammatory processes promote tissue remodeling at the infarct site. Procollagen III amino-terminal propeptide (PIIINP) is a circulating biomarker of type III collagen synthesis that has been shown to be associated with changes in left ventricular ejection fraction (LVEF) and predicts the occurrence of heart failure after AMI. We hypothesize that sleep-disordered breathing (SDB) promotes inflammation and myocardial fibrosis, leading to reduced myocardial salvage. Therefore, in patients with first-time AMI successfully treated with percutaneous coronary intervention (PCI), we aimed to investigate whether circulating levels of high-sensitivity C-reactive protein (hs-CRP) and PIIINP are elevated in patients with SDB compared to patients without SDB. Methods and Results: This cross-sectional analysis included a total of 88 eligible patients with first AMI and PCI pooled from two prospective studies and stratified according to the apnea–hypopnea index (AHI, with SDB: AHI ≥ 15 h−1). We analyzed circulating levels of hs-CRP and PIIINP 3–5 days after PCI. Patients with SDB had significantly higher levels of hs-CRP (18.3 mg/L [95% CI, 8.0–42.6] vs. 5.8 mg/L [95% CI, 4.2–19.8], p = 0.002) and PIIINP (0.49 U/mL [95% CI, 0.40–0.60] vs. 0.33 U/mL [95% CI, 0.28–0.43], p < 0.001). In a multivariable linear regression model accounting for important clinical confounders, SDB significantly predicted circulating levels of hs-CRP (p = 0.028). Similarly, only SDB was independently associated with PIIINP (p < 0.001). Only obstructive but not central AHI correlated with circulating levels of hs-CRP (p = 0.012) and PIIINP (p = 0.006) levels. Conclusions: The presence of obstructive SDB after AMI was independently associated with increased circulating levels of hs-CRP and PIIINP. Our results emphasize the important role of SDB as a common comorbidity and indicate increased inflammation and myocardial fibrosis in these patients.
New Advances in Antenna Design toward Wearable Devices Based on Nanomaterials
Authors: Wang Chunge , Zhang Ning , Liu Chen , Ma Bangbang , Zhang Keke , Li Rongzhi , Wang Qianqian , Zhang Sheng
Published: January 2024

Wearable antennas have recently garnered significant attention due to their attractive properties and potential for creating lightweight, compact, low-cost, and multifunctional wireless communication systems. With the breakthrough progress in nanomaterial research, the use of lightweight materials has paved the way for the widespread application of wearable antennas. Compared with traditional metallic materials like copper, aluminum, and nickel, nanoscale entities including zero-dimensional (0-D) nanoparticles, one-dimensional (1-D) nanofibers or nanotubes, and two-dimensional (2-D) nanosheets exhibit superior physical, electrochemical, and performance characteristics. These properties significantly enhance the potential for constructing durable electronic composites. Furthermore, the antenna exhibits compact size and high deformation stability, accompanied by greater portability and wear resistance, owing to the high surface-to-volume ratio and flexibility of nanomaterials. This paper systematically discusses the latest advancements in wearable antennas based on 0-D, 1-D, and 2-D nanomaterials, providing a comprehensive overview of their development and future prospects in the field.
Recent Developments in Paper-Based Sensors with Instrument-Free Signal Readout Technologies (2020–2023)
Authors: Yang Danni , Hu Chengju , Zhang Hao , Geng Shan
Published: January 2024

Signal readout technologies that do not require any instrument are essential for improving the convenience and availability of paper-based sensors. Thanks to the remarkable progress in material science and nanotechnology, paper-based sensors with instrument-free signal readout have been developed for multiple purposes, such as biomedical detection, environmental pollutant tracking, and food analysis. In this review, the developments in instrument-free signal readout technologies for paper-based sensors from 2020 to 2023 are summarized. The instrument-free signal readout technologies, such as distance-based signal readout technology, counting-based signal readout technology, text-based signal readout technology, as well as other transduction technologies, are briefly introduced, respectively. On the other hand, the applications of paper-based sensors with instrument-free signal readout technologies are summarized, including biomedical analysis, environmental analysis, food analysis, and other applications. Finally, the potential and difficulties associated with the advancement of paper-based sensors without instruments are discussed.
Rapid and Easy Detection of Microcystin-LR Using a Bioactivated Multi-Walled Carbon Nanotube-Based Field-Effect Transistor Sensor
Authors: Lee Myeongsoon , Kim Seong H. , Kim Don , Kim Hak Jun
Published: January 2024

In this study, we developed a multi-walled carbon nanotube (MWCNT)-based field-effect transistor (MWCNT-FET) sensor with high sensitivity and selectivity for microcystin-LR (MC-LR). Carboxylated MWCNTs were activated with an MC-LR-targeting aptamer (MCTA). Subsequently the bioactivated MWCNTs were immobilized between interdigitated drain (D) and source (S) electrodes through self-assembly. The top-gated MWCNT-FET sensor was configured by dropping the sample solution onto the D and S electrodes and immersing a Ag/AgCl electrode in the sample solution as a gate (G) electrode. We believe that the FET sensor’s conduction path arises from the interplay between the MCTAs, with the applied gate potential modulating this path. Using standard instruments and a personal computer, the sensor’s response was detected in real-time within a 10 min time frame. This label-free FET sensor demonstrated an impressive detection capability for MC-LR in the concentration range of 0.1–0.5 ng/mL, exhibiting a lower detection limit of 0.11 ng/mL. Additionally, the MWCNT-FET sensor displayed consistent reproducibility, a robust selectivity for MC-LR over its congeners, and minimal matrix interferences. Given these attributes, this easily mass-producible FET sensor is a promising tool for rapid, straightforward, and sensitive MC-LR detection in freshwater environments.
The Fibromyalgia Decomposition Phenomenon: A Reflexive Thematic Analysis
Authors: Fitzmaurice Bethany C. , Grenfell Rebecca L. , Heneghan Nicola R. , Rayen Asius T. A. , Soundy Andrew A.
Published: January 2024

Research is needed that can provide an illustration of the different biopsychosocial and environmental experiences of people with fibromyalgia to consider how healthcare professionals can best engage with the challenges that are faced. Qualitative research is well-positioned to do this. The current study used interpretive hermeneutic phenomenology situated within a pragmatic worldview, the aim being to obtain a deeper exploration of the fibromyalgia experience prior to commencing a novel intervention. A purposive sample of individuals with fibromyalgia were selected to undertake a single interview. The interviews were analysed using a thematic analysis. The themes identified key processes of the experience. A total of 16 participants (mean age: 47.1 years) took part. Three themes and 15 sub-themes were identified, together with a process linking different experiences together. The research from this small cohort provides a clear identification of multiple components influencing the experience of fibromyalgia and the decisions around lifestyle and choices made. From this, a novel decomposition/recomposition spiral has been identified, which will benefit patients and healthcare professionals alike. An earlier diagnosis and, thus, earlier and broader treatment options can help to improve functional outcomes.
Influence of Lymphatic, Microvascular and Perineural Invasion on Oncological Outcome in Patients with Neuroendocrine Tumors of the Small Intestine
Authors: Butz Frederike , Dukaczewska Agata , Kunze Catarina Alisa , Krömer Janina Maren , Reinhard Lisa , Jann Henning , Fehrenbach Uli , Müller-Debus Charlotte Friederieke , Skachko Tatiana , Pratschke Johann , Goretzki Peter E. , Mogl Martina T. , Dobrindt Eva Maria
Published: January 2024

For the histopathological work-up of resected neuroendocrine tumors of the small intestine (siNET), the determination of lymphatic (LI), microvascular (VI) and perineural (PnI) invasion is recommended. Their association with poorer prognosis has already been demonstrated in many tumor entities. However, the influence of LI, VI and PnI in siNET has not been sufficiently described yet. A retrospective analysis of all patients treated for siNET at the ENETS Center of Excellence Charité–Universitätsmedizin Berlin, from 2010 to 2020 was performed (n = 510). Patients who did not undergo primary resection or had G3 tumors were excluded. In the entire cohort (n = 161), patients with LI, VI and PnI status had more distant metastases (48.0% vs. 71.4%, p = 0.005; 47.1% vs. 84.4%, p < 0.001; 34.2% vs. 84.7%, p < 0.001) and had lower rates of curative surgery (58.0% vs. 21.0%, p < 0.001; 48.3% vs. 16.7%, p < 0.001; 68.4% vs. 14.3%, p < 0.001). Progression-free survival was significantly reduced in patients with LI, VI or PnI compared to patients without. This was also demonstrated in patients who underwent curative surgery. Lymphatic, vascular and perineural invasion were associated with disease progression and recurrence in patients with siNET, and these should therefore be included in postoperative treatment considerations.
Glioma–Immune Cell Crosstalk in Tumor Progression
Authors: Elguindy Mahmoud , Young Jacob S. , Mondal Isha , Lu Rongze O. , Ho Winson S.
Published: January 2024

Glioma progression is a complex process controlled by molecular factors that coordinate the crosstalk between tumor cells and components of the tumor microenvironment (TME). Among these, immune cells play a critical role in cancer survival and progression. The complex interplay between cancer cells and the immune TME influences the outcome of immunotherapy and other anti-cancer therapies. Here, we present an updated view of the pro- and anti-tumor activities of the main myeloid and lymphocyte cell populations in the glioma TME. We review the underlying mechanisms involved in crosstalk between cancer cells and immune cells that enable gliomas to evade the immune system and co-opt these cells for tumor growth. Lastly, we discuss the current and experimental therapeutic options being developed to revert the immunosuppressive activity of the glioma TME. Knowledge of the complex interplay that elapses between tumor and immune cells may help develop new combination treatments able to overcome tumor immune evasion mechanisms and enhance response to immunotherapies.
Impact of Low Muscle Mass on Hepatocellular Carcinoma Patients Undergoing Transcatheter Liver-Directed Therapies: Systematic Review & Meta-Analysis
Authors: Chen Yen-Chun , Kuo Meng-Hsuan , Hsu Ching-Sheng , Kao I-Ting , Wu Chen-Yi , Tseng Chih-Wei , Shao Shih-Chieh
Published: January 2024

Background and Aim: Transcatheter liver-directed intra-arterial therapies are mainstream treatment options for intermediate-stage hepatocellular carcinoma (HCC). However, the effect of low skeletal muscle mass (LSMM) on overall survival (OS) in these patients remains uncertain. We aimed to ascertain the prevalence and prognostic effect of LSMM in this population. Method: According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, a comprehensive search was performed in the PubMed and Embase databases until Oct 2023. Random-effects meta-analysis was performed to determine the pooled prevalence of LSMM and calculate the hazard ratio (HR) for OS with a 95% confidence interval (CI) in patients with intermediate-stage HCC undergoing various transarterial therapies, comparing those with and without LSMM. Results: Twelve studies involving 2450 patients were included. The pooled prevalence of LSMM was 46% (95% CI, 38–55%), and the results were consistent across different treatments, regions, and age subgroups. The meta-analysis indicated that LSMM was significantly associated with decreased OS (HR, 1.78; 95% CI, 1.36–2.33; I2, 75%). Subgroup analyses reassured the main findings across various therapies, including transarterial chemoembolization (TACE) (HR, 1.68; 95% CI, 1.23–2.30; I2, 81%), transarterial embolization (TAE) (HR, 2.45; 95% CI, 1.42–4.22; I2, 0%), and transarterial radioembolization (TARE) (HR, 1.94; 95% CI, 1.01–3.73; I2, 0%). Conclusions: In intermediate-stage HCC, LSMM is common and associated with reduced OS. To achieve an optimal prognosis, clinicians should incorporate routine LSMM measurement into practice, while caring for patients with intermediate-stage HCC, irrespective of TACE, TAE, and TARE.
Stem Cell Growth Factor-β as a Predictive Biomarker of Response to Chemotherapy and Prognosis in Patients with Advanced-Stage Hepatocellular Carcinoma: A Retrospective Study
Authors: Kimura Masamichi , Nishikawa Koji , Imamura Jun , Kimura Kiminori
Published: January 2024

In this retrospective study, we investigated the potential application of serum stem cell growth factor beta (SCGF-β) as a biomarker for predicting the therapeutic response and prognosis in patients with hepatocellular carcinoma (HCC) undergoing atezolizumab and bevacizumab (Atz/Bev) combination therapy. Pre- and post-treatment serum SCGF-β levels were measured and analyzed in relation to treatment outcomes and overall survival (OS). Pretreatment SCGF-β levels were associated with treatment response. Patients with SCGF-β levels exceeding the 163,295 pg/mL cutoff experienced significantly reduced OS, with a median OS of 12.03 months, compared to 28.87 months in those with SCGF-β levels at or below this threshold. These findings suggest that SCGF-β can serve as a predictive marker for clinical outcomes in HCC treatment, highlighting the need for prospective studies to further validate these results and clarify the mechanisms underlying SCGF-β-related therapeutic resistance.
Evaluating Recalibrating AI Models for Breast Cancer Diagnosis in a New Context: Insights from Transfer Learning, Image Enhancement and High-Quality Training Data Integration
Authors: Jiang Zhengqiang , Gandomkar Ziba , Trieu Phuong Dung (Yun) , Tavakoli Taba Seyedamir , Barron Melissa L. , Obeidy Peyman , Lewis Sarah J.
Published: January 2024

This paper investigates the adaptability of four state-of-the-art artificial intelligence (AI) models to the Australian mammographic context through transfer learning, explores the impact of image enhancement on model performance and analyses the relationship between AI outputs and histopathological features for clinical relevance and accuracy assessment. A total of 1712 screening mammograms (n = 856 cancer cases and n = 856 matched normal cases) were used in this study. The 856 cases with cancer lesions were annotated by two expert radiologists and the level of concordance between their annotations was used to establish two sets: a ‘high-concordances subset’ with 99% agreement of cancer location and an ‘entire dataset’ with all cases included. The area under the receiver operating characteristic curve (AUC) was used to evaluate the performance of Globally aware Multiple Instance Classifier (GMIC), Global-Local Activation Maps (GLAM), I&H and End2End AI models, both in the pretrained and transfer learning modes, with and without applying the Contrast Limited Adaptive Histogram Equalization (CLAHE) algorithm. The four AI models with and without transfer learning in the high-concordance subset outperformed those in the entire dataset. Applying the CLAHE algorithm to mammograms improved the performance of the AI models. In the high-concordance subset with the transfer learning and CLAHE algorithm applied, the AUC of the GMIC model was highest (0.912), followed by the GLAM model (0.909), I&H (0.893) and End2End (0.875). There were significant differences (p < 0.05) in the performances of the four AI models between the high-concordance subset and the entire dataset. The AI models demonstrated significant differences in malignancy probability concerning different tumour size categories in mammograms. The performance of AI models was affected by several factors such as concordance classification, image enhancement and transfer learning. Mammograms with a strong concordance with radiologists’ annotations, applying image enhancement and transfer learning could enhance the accuracy of AI models.
Minimally Invasive Pancreaticoduodenectomy in Elderly versus Younger Patients: A Meta-Analysis
Authors: Ballarin Roberto , Esposito Giuseppe , Guerrini Gian Piero , Magistri Paolo , Catellani Barbara , Guidetti Cristiano , Di Sandro Stefano , Di Benedetto Fabrizio
Published: January 2024

(1) Background: With ageing, the number of pancreaticoduodenectomies (PD) for benign or malignant disease is expected to increase in elderly patients. However, whether minimally invasive pancreaticoduodenectomy (MIPD) should be performed in the elderly is not clear yet and it is still debated. (2) Materials and Methods: A systematic review and meta-analysis was conducted including seven published articles comparing the technical and post-operative outcomes of MIPD in elderly versus younger patients up to December 2022. (3) Results: In total, 1378 patients were included in the meta-analysis. In term of overall and Clavien–Dindo I/II complication rates, post-operative pancreatic fistula (POPF) grade > A rates and biliary leakage, abdominal collection, post-operative bleeding and delayed gastric emptying rates, no differences emerged between the two groups. However, this study showed slightly higher intraoperative blood loss [MD 43.41, (95%CI 14.45, 72.38) p = 0.003], Clavien–Dindo ≥ III complication rates [OR 1.87, (95%CI 1.13, 3.11) p = 0.02] and mortality rates [OR 2.61, (95%CI 1.20, 5.68) p = 0.02] in the elderly compared with the younger group. Interestingly, as a minor endpoint, no differences in terms of the mean number of harvested lymphnode and of R0 resection rates were found. (4) Conclusion: MIPD seems to be relatively safe; however, there are slightly higher major morbidity, lung complication and mortality rates in elderly patients, who potentially represent the individuals that may benefit the most from the minimally invasive approach.
Exploring the Genomic Landscape of Hepatobiliary Cancers to Establish a Novel Molecular Classification System
Authors: Scholer Anthony J. , Marcus Rebecca K. , Garland-Kledzik Mary , Ghosh Debopriya , Ensenyat-Mendez Miquel , Germany Joshua , Santamaria-Barria Juan A. , Khader Adam , Orozco Javier I. J. , Goldfarb Melanie
Published: January 2024

Taxonomy of hepatobiliary cancer (HBC) categorizes tumors by location or histopathology (tissue of origin, TO). Tumors originating from different TOs can also be grouped by overlapping genomic alterations (GA) into molecular subtypes (MS). The aim of this study was to create novel HBC MSs. Next-generation sequencing (NGS) data from the AACR-GENIE database were used to examine the genomic landscape of HBCs. Machine learning and gene enrichment analysis identified MSs and their oncogenomic pathways. Descriptive statistics were used to compare subtypes and their associations with clinical and molecular variables. Integrative analyses generated three MSs with different oncogenomic pathways independent of TO (n = 324; p < 0.05). HC-1 “hyper-mutated-proliferative state” MS had rapidly dividing cells susceptible to chemotherapy; HC-2 “adaptive stem cell-cellular senescence” MS had epigenomic alterations to evade immune system and treatment-resistant mechanisms; HC-3 “metabolic-stress pathway” MS had metabolic alterations. The discovery of HBC MSs is the initial step in cancer taxonomy evolution and the incorporation of genomic profiling into the TNM system. The goal is the development of a precision oncology machine learning algorithm to guide treatment planning and improve HBC outcomes. Future studies should validate findings of this study, incorporate clinical outcomes, and compare the MS classification to the AJCC 8th staging system.
Circadian Rhythms, Chrononutrition, Physical Training, and Redox Homeostasis—Molecular Mechanisms in Human Health
Authors: Drăgoi Cristina Manuela , Nicolae Alina Crenguţa , Ungurianu Anca , Margină Denisa Marilena , Grădinaru Daniela , Dumitrescu Ion-Bogdan
Published: January 2024

A multitude of physiological processes, human behavioral patterns, and social interactions are intricately governed by the complex interplay between external circumstances and endogenous circadian rhythms. This multidimensional regulatory framework is susceptible to disruptions, and in contemporary society, there is a prevalent occurrence of misalignments between the circadian system and environmental cues, a phenomenon frequently associated with adverse health consequences. The onset of most prevalent current chronic diseases is intimately connected with alterations in human lifestyle practices under various facets, including the following: reduced physical activity, the exposure to artificial light, also acknowledged as light pollution, sedentary behavior coupled with consuming energy-dense nutriments, irregular eating frameworks, disruptions in sleep patterns (inadequate quality and duration), engagement in shift work, and the phenomenon known as social jetlag. The rapid evolution of contemporary life and domestic routines has significantly outpaced the rate of genetic adaptation. Consequently, the underlying circadian rhythms are exposed to multiple shifts, thereby elevating the susceptibility to disease predisposition. This comprehensive review endeavors to synthesize existing empirical evidence that substantiates the conceptual integration of the circadian clock, biochemical molecular homeostasis, oxidative stress, and the stimuli imparted by physical exercise, sleep, and nutrition.
The Proteomic Composition and Organization of Constitutive Heterochromatin in Mouse Tissues
Authors: Schmidt Annika , Zhang Hui , Schmitt Stephanie , Rausch Cathia , Popp Oliver , Chen Jiaxuan , Cmarko Dusan , Butter Falk , Dittmar Gunnar , Lermyte Frederik , Cardoso M. Cristina
Published: January 2024

Pericentric heterochromatin (PCH) forms spatio-temporarily distinct compartments and affects chromosome organization and stability. Albeit some of its components are known, an elucidation of its proteome and how it differs between tissues in vivo is lacking. Here, we find that PCH compartments are dynamically organized in a tissue-specific manner, possibly reflecting compositional differences. As the mouse brain and liver exhibit very different PCH architecture, we isolated native PCH fractions from these tissues, analyzed their protein compositions using quantitative mass spectrometry, and compared them to identify common and tissue-specific PCH proteins. In addition to heterochromatin-enriched proteins, the PCH proteome includes RNA/transcription and membrane-related proteins, which showed lower abundance than PCH-enriched proteins. Thus, we applied a cut-off of PCH-unspecific candidates based on their abundance and validated PCH-enriched proteins. Amongst the hits, MeCP2 was classified into brain PCH-enriched proteins, while linker histone H1 was not. We found that H1 and MeCP2 compete to bind to PCH and regulate PCH organization in opposite ways. Altogether, our workflow of unbiased PCH isolation, quantitative mass spectrometry, and validation-based analysis allowed the identification of proteins that are common and tissue-specifically enriched at PCH. Further investigation of selected hits revealed their opposing role in heterochromatin higher-order architecture in vivo.
Pathological and Therapeutical Implications of Pyroptosis in Psoriasis and Hidradenitis Suppurativa: A Narrative Review
Authors: Krajewski Piotr , Tsoukas Maria , Szepietowski Jacek
Published: January 2024

This manuscript explores the role of pyroptosis, an inflammatory programmed cell death, in the pathogenesis of two chronic dermatoses, psoriasis and hidradenitis suppurativa (HS). The diseases, though clinically diverse, share common pathogenetic pathways involving the unbalanced interaction between the adaptive and innate immune systems. This review focuses on the molecular changes in psoriatic and HS skin, emphasizing the activation of dendritic cells, secretion of interleukins (IL-17, IL-22, and TNF-α), and the involvement of inflammasomes, particularly NLRP3. This manuscript discusses the role of caspases, especially caspase-1, in driving pyroptosis and highlights the family of gasdermins (GSDMs) as key players in the formation of pores leading to cell rupture and the release of proinflammatory signals. This study delves into the potential therapeutic implications of targeting pyroptosis in psoriasis and HS, examining existing medications like biologics and Janus kinase inhibitors. It also reviews the current limitations and challenges in developing therapies that selectively target pyroptosis. Additionally, the manuscript explores the role of pyroptosis in various inflammatory disorders associated with psoriasis and HS, such as inflammatory bowel disease, diabetes mellitus, and cardiovascular disorders. The review concludes by emphasizing the need for further research to fully elucidate the pathomechanisms of these dermatoses and develop effective, targeted therapies.
Coatings and Surface Modification of Alloys for Tribo-Corrosion Applications
Authors: Wood Robert J. K. , Lu Ping
Published: January 2024

This review of the tribocorrosion of coatings and surface modifications covers nearly 195 papers and reviews that have been published in the past 15 years, as compared to only 37 works published up to 2007, which were the subject of a previous review published in 2007. It shows that the research into the subject area is vibrant and growing, to cover emerging deposition, surface modification and testing techniques as well as environmental influences and modelling developments. This growth reflects the need for machines to operate in harsh environments coupled with requirements for increased service life, lower running costs and improved safety factors. Research has also reacted to the need for multifunctional coating surfaces as well as functionally graded systems with regard to depth. The review covers a range of coating types designed for a wide range of potential applications. The emerging technologies are seen to be molten-, solution-, PVD- and PEO-based coatings, with CVD coatings being a less popular solution. There is a growing research interest in duplex surface engineering and coating systems. Surface performance shows a strong playoff between wear, friction and corrosion rates, often with antagonistic relationships and complicated interactions between multiple mechanisms at different scale lengths within tribocorrosion contacts. The tribologically induced stresses are seen to drive damage propagation and accelerate corrosion either within the coating or at the coating coating–substrate interface. This places a focus on coating defect density. The environment (such as pH, DO2, CO2, salinity and temperature) is also shown to have a strong influence on tribocorrosion performance. Coating and surface modification solutions being developed for tribocorrosion applications include a whole range of electrodeposited coatings, hard and tough coatings and high-impedance coatings such as doped diamond-like carbon. Hybrid and multilayered coatings are also being used to control damage penetration into the coating (to increase toughness) and to manage stresses. A particular focus involves the combination of various treatment techniques. The review also shows the importance of the microstructure, the active phases that are dissolved and the critical role of surface films and their composition (oxide or passive) in tribocorrosion performance which, although discovered for bulk materials, is equally applicable to coating performance. New techniques show methods for revealing the response of surfaces to tribocorrosion (i.e., scanning electrochemical microscopy). Modelling tribocorrosion has yet to embrace the full range of coatings and the fact that some coatings/environments result in reduced wear and thus are antagonistic rather than synergistic. The actual synergistic/antagonistic mechanisms are not well understood, making them difficult to model.