bluuebunny/crossref_metadata_2025 huggingface dataset:
Calculation of Configurational Entropy in Complex Landscapes
Authors: Cushman Samuel A
Published: April 2018

Entropy and the second law of thermodynamics are fundamental concepts that underlie all natural processes and patterns. Recent research has shown how the entropy of a landscape mosaic can be calculated using the Boltzmann equation, with the entropy of a lattice mosaic equal to the logarithm of the number of ways a lattice with a given dimensionality and number of classes can be arranged to produce the same total amount of edge between cells of different classes. However, that work seemed to also suggest that the feasibility of applying this method to real landscapes was limited due to intractably large numbers of possible arrangements of raster cells in large landscapes. Here I extend that work by showing that: (1) the proportion of arrangements rather than the number with a given amount of edge length provides a means to calculate unbiased relative configurational entropy, obviating the need to compute all possible configurations of a landscape lattice; (2) the edge lengths of randomized landscape mosaics are normally distributed, following the central limit theorem; and (3) given this normal distribution it is possible to fit parametric probability density functions to estimate the expected proportion of randomized configurations that have any given edge length, enabling the calculation of configurational entropy on any landscape regardless of size or number of classes. I evaluate the boundary limits (4) for this normal approximation for small landscapes with a small proportion of a minority class and show it holds under all realistic landscape conditions. I further (5) demonstrate that this relationship holds for a sample of real landscapes that vary in size, patch richness, and evenness of area in each cover type, and (6) I show that the mean and standard deviation of the normally distributed edge lengths can be predicted nearly perfectly as a function of the size, patch richness and diversity of a landscape. Finally, (7) I show that the configurational entropy of a landscape is highly related to the dimensionality of the landscape, the number of cover classes, the evenness of landscape composition across classes, and landscape heterogeneity. These advances provide a means for researchers to directly estimate the frequency distribution of all possible macrostates of any observed landscape, and then directly calculate the relative configurational entropy of the observed macrostate, and to understand the ecological meaning of different amounts of configurational entropy. These advances enable scientists to take configurational entropy from a concept to an applied tool to measure and compare the disorder of real landscapes with an objective and unbiased measure based on entropy and the second law.
Quantum Nonlocality and Quantum Correlations in the Stern–Gerlach Experiment
Authors: Piceno Martínez Alma Elena , Benítez Rodríguez Ernesto , Mendoza Fierro Julio Abraham , Méndez Otero Marcela Maribel , Arévalo Aguilar Luis Manuel
Published: April 2018

The Stern–Gerlach experiment (SGE) is one of the foundational experiments in quantum physics. It has been used in both the teaching and the development of quantum mechanics. However, for various reasons, some of its quantum features and implications are not fully addressed or comprehended in the current literature. Hence, the main aim of this paper is to demonstrate that the SGE possesses a quantum nonlocal character that has not previously been visualized or presented before. Accordingly, to show the nonlocality into the SGE, we calculate the quantum correlations C ( z , θ ) by redefining the Banaszek–Wódkiewicz correlation in terms of the Wigner operator, that is C ( z , θ ) = ⟨ Ψ | W ^ ( z , p z ) σ ^ ( θ ) | Ψ ⟩ , where W ^ ( z , p z ) is the Wigner operator, σ ^ ( θ ) is the Pauli spin operator in an arbitrary direction θ and | Ψ ⟩ is the quantum state given by an entangled state of the external degree of freedom and the eigenstates of the spin. We show that this correlation function for the SGE violates the Clauser–Horne–Shimony–Holt Bell inequality. Thus, this feature of the SGE might be interesting for both the teaching of quantum mechanics and to investigate the phenomenon of quantum nonlocality.
Counteracting Destructive Student Misconceptions of Mathematics
Authors: Jankvist Uffe Thomas , Niss Mogens
Published: April 2018

In this article, we ask the question of what it takes for targeted efforts to be reasonably successful in altering students’ misconceptions and unproductive beliefs and ensuing myths about mathematics as a discipline and a school subject and about themselves in relation to mathematics, so as to pave the way for satisfactory learning. We attempt to answer this question through the analysis of three cases of upper secondary school students, who all struggled with mathematics-related difficulties due to myths resulting from misguided beliefs, erroneous proof schemes, or mistaken interpretations of the didactical contract, the three theoretical constructs we employ in the study. We describe how specially educated teachers, so-called “mathematics counsellors”, taking part in a professional development program conducted by the authors, were able, firstly, to identity these students, then to diagnose more precisely the nature of their difficulties, and finally to design targeted interventions in order to assist the students in actually overcoming (parts of) their difficulties and eventually dispelling some of the myths they were influenced by. We further offer an analysis of the elements responsible for the success of these interventions. More precisely, we identify five such elements. Finally, we zoom in on the role and intricate connectedness of the three theoretical constructs mentioned above.
High-Efficiency Small-Scale Combined Heat and Power Organic Binary Rankine Cycles
Authors: Invernizzi Costante Mario , Ahmed Sheikh Nadeem
Published: April 2018

Small-CHP (Combined Heat and Power) systems are generally considered a valuable technological option to the conventional boilers, in a technology developed context. If small-CHP systems are associated with the use of renewable energies (biomass, for example) they could play an important role in distributed generation even in developing countries or, in any case, where there are no extensive electricity networks. Traditionally the considered heat engines for micro- or mini-CHP are: the gas engine, the gas turbine (with internal combustion), the steam engine, engine working according to the Stirling and to the Rankine cycles, the last with organic fluids. In principle, also fuel cells could be used. In this paper, we focus on small size Rankine cycles (10–15 k W ) with organic working fluids. The assumed heat source is hot combustion gases at high temperature (900–950 ∘ C ) and we assume to use only single stages axial turbines. The need to work at high temperatures, limits the choice of the right organic working fluids. The calculation results show the limitation in the performances of simple cycles and suggest the opportunity to resort to complex (binary) cycle configurations to achieve high net conversion efficiencies (15–16%).
Effects of Walking on Coronary Heart Disease in Elderly Men with Diabetes
Authors: Kimata Chieko , Willcox Bradley , Rodriguez Beatriz L.
Published: April 2018

Previous studies have shown that walking is associated with increased longevity and a reduced risk of cardiovascular and age-related diseases. Whether walking benefits individuals with diabetes who are at high risk of coronary heart disease (CHD) remains to be determined. The objective of this study is to examine the association between walking and risk of CHD among elderly men with and without diabetes. Walking data was assessed in 2732 men aged 71 to 93 years participating in the Honolulu Heart Program from 1991–1993. Study participants were initially without disabilities and free of prevalent CHD. Men were then followed for incident CHD for up to 7 years. For men with diabetes who walked <0.25 miles/day, the age-adjusted incidence of CHD was significantly higher than in men without diabetes (27.1 vs. 12.7/1000 person years, p = 0.026). In contrast when distance walked was >1.5 miles/day, incidence of CHD was similar in men with and without diabetes (12.2 vs. 9.1/1000 person-years, p = 0.46). While risk of CHD declined significantly with increasing walking distance in men with diabetes after age and risk factor adjustment (p = 0.043, p = 0.025), associations in those without diabetes were weaker (p = 0.070, p = 0.10). These findings suggest that among elderly men with diabetes who are capable of physical activity, walking reduces CHD risk to levels similar to when diabetes is absent. Walking is an easy, safe and accessible form of physical activity that may have marked health benefits for elderly men with diabetes.
Mapping and Modelling Malaria Risk Areas Using Climate, Socio-Demographic and Clinical Variables in Chimoio, Mozambique
Authors: Ferrao Joao L. , Niquisse Sergio , Mendes Jorge M. , Painho Marco
Published: April 2018

Background: Malaria continues to be a major public health concern in Africa. Approximately 3.2 billion people worldwide are still at risk of contracting malaria, and 80% of deaths caused by malaria are concentrated in only 15 countries, most of which are in Africa. These high-burden countries have achieved a lower than average reduction of malaria incidence and mortality, and Mozambique is among these countries. Malaria eradication is therefore one of Mozambique’s main priorities. Few studies on malaria have been carried out in Chimoio, and there is no malaria map risk of the area. This map is important to identify areas at risk for application of Public Precision Health approaches. By using GIS-based spatial modelling techniques, the research goal of this article was to map and model malaria risk areas using climate, socio-demographic and clinical variables in Chimoio, Mozambique. Methods: A 30 m × 30 m Landsat image, ArcGIS 10.2 and BioclimData were used. A conceptual model for spatial problems was used to create the final risk map. The risks factors used were: the mean temperature, precipitation, altitude, slope, distance to water bodies, distance to roads, NDVI, land use and land cover, malaria prevalence and population density. Layers were created in a raster dataset. For class value comparisons between layers, numeric values were assigned to classes within each map layer, giving them the same importance. The input dataset were ranked, with different weights according to their suitability. The reclassified outputs of the data were combined. Results: Chimoio presented 96% moderate risk and 4% high-risk areas. The map showed that the central and south-west “Residential areas”, namely, Centro Hipico, Trangapsso, Bairro 5 and 1° de Maio, had a high risk of malaria, while the rest of the residential areas had a moderate risk. Conclusions: The entire Chimoio population is at risk of contracting malaria, and the precise estimation of malaria risk, therefore, has important precision public health implications and for the planning of effective control measures, such as the proper time and place to spray to combat vectors, distribution of bed nets and other control measures.
The Antecedents and Consequences of Health Literacy in an Ecological Perspective: Results from an Experimental Analysis
Authors: Lorini Chiara , Ierardi Francesca , Bachini Letizia , Donzellini Martina , Gemmi Fabrizio , Bonaccorsi Guglielmo
Published: April 2018

This study analyses the relationship between the antecedents and consequences of health literacy (HL) at the ecological level among the nations involved in the European Health Literacy Survey (HLS-EU). The antecedents and consequences were investigated by means of proxy indicators. The HL was measured using the 47-item HLS-EU questionnaire (HLS-EUQ47) and the Newest Vital Sign (NVS). The two measures stood in significant correlation to the outcomes of the sub-discipline of the Euro Health Consumer Index (r = 0.790 for HLS-EUQ47; r = 0.789 for NVS). The HLS-EUQ47 also stood in correlation to the percentage of population with post-secondary education (r = 0.810), the reading performance for 15-year-old students (r = 0.905), the presence of a national screening program for breast (r = 0.732) or cervical cancer (r = 0.873). The NVS stood in correlation with the unemployment rate (r = −0.778), the Gross Domestic Product (r = 0.719), the Gini coefficient (r = −0.743), the rank of the Euro Patient Empowerment Index (r = −0.826), the expenditure on social protection (r = 0.814), the Consumer Empowerment Index (r = 0.898), the percentage of adults using the internet for seeking health information (r = 0.759), the prevalence of overweight individuals (r = −0.843), the health expenditure (r = 0.766), as well as the percentage of individuals using the internet for interacting with public authorities (r = 0.755). This study provides some preliminary considerations regarding alternative means by which to study HL and proposes new methods for experimentation. The methods and the results could offer a means by which the relationship between society and overall healthcare protection could be strengthened.
Association of Anthropometric Indices of Obesity with Hypertension in Chinese Elderly: An Analysis of Age and Gender Differences
Authors: Wang Qian , Xu Lingzhong , Li Jiajia , Sun Long , Qin Wenzhe , Ding Gan , Zhu Jing , Zhang Jiao , Yu Zihang , Xie Su
Published: April 2018

This study aims to explore the association of anthropometric indices of obesity with hypertension in Chinese elderly and its possible gender and age differences. A total of 7070 adults age 60 or older were interviewed in a cross-sectional study conducted in 2017. Anthropometric indices for each participant were measured by using standard methods of trained doctoral/master students. We performed two binary logistic regression models to examine the association of the nine different anthropometric indices and hypertension by gender. Lastly, analyses were performed in two steps stratified for age. Comparing individuals with and without hypertension, there were statistically significant differences in anthropometric indices except height, a body shape index (ABSI), and hip index (HI) in males; and except height in females. There were gender differences in the relationship between anthropometric indices and the prevalence of hypertension in Chinese older adults. After stratification by age, the associations of all anthropometric indices became weaker, disappeared, or even went in the opposite direction. Furthermore, body mass index (BMI) in men (except individuals older than 80) and hip circumference (HC) in women showed a significant impact on the risk of hypertension. The association of anthropometric indices of obesity with hypertension in Chinese elderly differ by gender and age. These findings indicate a need to develop gender-specific strategies for the male and female elderly in the primary and secondary prevention of hypertension.
Assessment of Regional Ecosystem Health—A Case Study of the Golden Triangle of Southern Fujian Province, China
Authors: Wang Ziyan , Tang Lina , Qiu Quanyi , Chen Huaxiang , Wu Tong , Shao Guofan
Published: April 2018

Intensifying urbanization and rapid population growth in Fujian Province, China, has caused pollution of air and water resources; this has adversely impacted ecosystems and human health. China has recently begun pursuing a massive infrastructure and economic development strategy called the Belt and Road Initiative, which could potentially cause further environmental damage. Evaluations of ecosystem health are therefore a first step towards identifying the potential impacts from the development and planning sustainable development strategies in the Golden Triangle of Southern Fujian. To this end, our study analyzed landscape patterns and evaluated ecosystem health in this region. We used an index system method to develop a pressure–state–response (PSR) model for assessing the region’s ecosystem health. We found that: (1) the landscape type with the greatest area in the study region is cultivated land and there were no areas that were undisturbed by human activity; (2) the overall ecological health of the region is good, but there is distinct variation across the region. This study incorporates the landscape pattern into an evaluation of ecosystem health. Using counties as evaluation units, we provide a general evaluation index for this scale. The methods reported here can be used in complex ecological environments to inform sustainable management decisions.
Convergence in Sleep Time Accomplished? Gender Gap in Sleep Time for Middle-Aged Adults in Korea
Authors: Cha Seung-Eun , Eun Ki-Soo
Published: April 2018

Although the gender gap in sleep time has narrowed significantly in the last decade, middle-aged women between ages 35 and 60 still sleep less than their male counterparts in Korea. This study examines and provides evidence for factors contributing to the gender gap in this age group. Using Korean Time Use Survey (KTUS) data from 2004, 2009 and 2014, we find that middle-aged women’s difficulty in managing work-life balance and traditional role expectations placed upon women are the main causes of the gender gap in sleep time. The decomposition analysis reveals that the improved socioeconomic status and recent changes in familial expectations for women may have helped them sleep more than in the past. However, there remain fundamental differences in attitude and time use patterns between men and women that prevent middle-aged women from getting the same amount of sleep.
The Potential of Integrating Provitamin A-Biofortified Maize in Smallholder Farming Systems to Reduce Malnourishment in South Africa
Authors: Zuma Mthokozisi , Kolanisi Unathi , Modi Albert
Published: April 2018

Biofortification interventions have the potential to combat malnutrition. This review explored the use of provitamin A-biofortified maize (PVABM) as a vitamin A deficiency (VAD) reduction agricultural-based strategy. Maize has been identified as one of the key staple crops for biofortification to reduce hidden hunger in Africa. Most nutrition interventions have not been successful in reducing hunger because rural communities, who mainly rely on agriculture, have been indirectly excluded. The biofortification intervention proposed here aims to be an inclusive strategy, based on smallholder farming systems. Vitamin A is a micronutrient essential for growth, immune function, reproduction and vision, and its deficiency results in VAD. VAD is estimated to affect more than 250 million children in developing countries. In Africa, especially sub-Saharan Africa, maize is a staple food for rural communities, consumed by most household members. Due to carotenoids, PVABM presents an orange color. This color has been reported to lead to negative perceptions about PVABM varieties. The perceived agronomic traits of this maize by smallholder farmers have not been explored. Adoption and utilization of PVABM varieties relies on both acceptable consumer attributes and agronomic traits, including nutritional value. It is therefore important to assess farmers’ perceptions of and willingness to adopt the varieties, and the potential markets for PVABM maize. It is essential to establish on-farm trials and experiments to evaluate the response of PVABM under different climatic conditions, fertilizer levels and soils, and its overall agronomic potential. For the better integration of PVABM with smallholder farming systems, farmer training and workshops about PVABM should be part of any intervention. A holistic approach would enhance farmers’ knowledge about PVABM varieties and that their benefits out-compete other existing maize varieties.
Proteomic Identification of the Galectin-1-Involved Molecular Pathways in Urinary Bladder Urothelial Carcinoma
Authors: Li Chien-Feng , Shen Kun-Hung , Chien Lan-Hsiang , Huang Cheng-Hao , Wu Ting-Feng , He Hong-Lin
Published: April 2018

Among various heterogeneous types of bladder tumors, urothelial carcinoma is the most prevalent lesion. Some of the urinary bladder urothelial carcinomas (UBUCs) develop local recurrence and may cause distal invasion. Galectin-1 de-regulation significantly affects cell transformation, cell proliferation, angiogenesis, and cell invasiveness. In continuation of our previous investigation on the role of galectin-1 in UBUC tumorigenesis, in this study, proteomics strategies were implemented in order to find more galectin-1-associated signaling pathways. The results of this study showed that galectin-1 knockdown could induce 15 down-regulated proteins and two up-regulated proteins in T24 cells. These de-regulated proteins might participate in lipid/amino acid/energy metabolism, cytoskeleton, cell proliferation, cell-cell interaction, cell apoptosis, metastasis, and protein degradation. The aforementioned dys-regulated proteins were confirmed by western immunoblotting. Proteomics results were further translated to prognostic markers by analyses of biopsy samples. Results of cohort studies demonstrated that over-expressions of glutamine synthetase, alcohol dehydrogenase (NADP+), fatty acid binding protein 4, and toll interacting protein in clinical specimens were all significantly associated with galectin-1 up-regulation. Univariate analyses showed that de-regulations of glutamine synthetase and fatty acid binding protein 4 in clinical samples were respectively linked to disease-specific survival and metastasis-free survival.
NF-κB-Mediated Inflammation in the Pathogenesis of Intracranial Aneurysm and Subarachnoid Hemorrhage. Does Autophagy Play a Role?
Authors: Pawlowska Elzbieta , Szczepanska Joanna , Wisniewski Karol , Tokarz Paulina , Jaskólski Dariusz J. , Blasiak Janusz
Published: April 2018

The rupture of saccular intracranial aneurysms (IA) is the commonest cause of non-traumatic subarachnoid hemorrhage (SAH)—the most serious form of stroke with a high mortality rate. Aneurysm walls are usually characterized by an active inflammatory response, and NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) has been identified as the main transcription factor regulating the induction of inflammation-related genes in IA lesions. This transcription factor has also been related to IA rupture and resulting SAH. We and others have shown that autophagy interacts with inflammation in many diseases, but there is no information of such interplay in IA. Moreover, NF-κB, which is a pivotal factor controlling inflammation, is regulated by autophagy-related proteins, and autophagy is regulated by NF-κB signaling. It was also shown that autophagy mediates the normal functioning of vessels, so its disturbance can be associated with vessel-related disorders. Early brain injury, delayed brain injury, and associated cerebral vasospasm are among the most serious consequences of IA rupture and are associated with impaired function of the autophagy–lysosomal system. Further studies on the role of the interplay between autophagy and NF-κB-mediated inflammation in IA can help to better understand IA pathogenesis and to identify IA patients with an increased SAH risk.
Microfluidic Synthesis of Ca-Alginate Microcapsules for Self-Healing of Bituminous Binder
Authors: Shu Benan , Wu Shaopeng , Dong Lijie , Wang Qing , Liu Quantao
Published: April 2018

This work aims to develop an original alginate micro-emulsion combining with droplets microfluidic method to produce multinuclear Ca-alginate microcapsules containing rejuvenator for the self-healing of bituminous binder. The sizes of the Ca-alginate microcapsules could be easily controlled by tuning flow rates of the continuous and dispersed phases. The addition of a surfactant Tween80 not only improved the stability of the emulsion, but it also effectively reduced the size of the microcapsules. Size predictive mathematical model of the microcapsules was proposed through the analysis of fluid force. Optical microscope and remote Fourier infrared test confirmed the multinuclear structure of Ca-alginate microcapsules. Thermogravimetric analysis showed that the microcapsules coated with nearly 40% rejuvenator and they remained intact during the preparation of bitumen specimen at 135 °C. Micro self-healing process of bituminous binder with multinuclear Ca-alginate microcapsules containing rejuvenator was monitored and showed enhanced self-healing performance. Tensile stress-recovery test revealed that the recovery rate increased by 32.08% (in the case of 5% microcapsules), which meant that the Ca-alginate microcapsules containing rejuvenator could effectively enhance the self-healing property of bituminous binder.
Changes in the Dependence of Pseudomonas aeruginosa O Serogroup Strains and Their Resistance to Antibiotics in a University Hospital During a 5-year Period
Authors: Vitkauskienė Astra , Skrodenienė Erika , Jomantienė Daiva , Macas Andrius , Sakalauskas Raimundas
Published: April 2018

The aim of our study was to determine the changes in antibiotic resistance and O serogroup dependence of P. aeruginosa strains isolated from lower respiratory tract specimens of patients in 2003 and 2008; the patients were treated in intensive care units of the biggest treatment facility in Lithuania (Hospital of Lithuanian University of Health Sciences, HLUHS, former Hospital of Kaunas University of Medicine) Material and Methods. The study included 90 P. aeruginosa strains serotyped in 2003 and 101 P. aeruginosa strains serotyped in 2008, which were randomly selected. The resistance of P. aeruginosa strains was determined by the disc diffusion method based on the standard guidelines. The sizes of inhibition zones were interpreted according to the National Committee for Clinical Laboratory Standards (M2-A6). Isolates were serotyped using sera with specific antibodies against the O antigens of P. aeruginosa (Bio-Rad, France). Results. Comparison of changes in the distribution of P. aeruginosa serogroups in 2003 and 2008 showed that P. aeruginosa strains of serogroups O:1, O:2, and O:3 were more prevalent in 2003 as compared with 2008 (23.3%, n=21; 27.8%, n=25; 12.2%, n=11 vs. 9.9%, n=10; 10.9%, n=11; 4.0%, n=4, P<0.05). P. aeruginosa strains of serogroups O:6 and O:11 were isolated more frequently in 2008 than 2003 (26.7%, n=27; 34.7%, n=35 vs. 4.4%, n=4; 10.0%, n=9, P<0.001). The results showed that 18 of the 90 P. aeruginosa strains in 2003 and 25 of the 101 P. aeruginosa strains in 2008 were resistant to three or more antibiotics tested, i.e., they were multidrug-resistant. Analysis of the distribution of serogroups among these P. aeruginosa strains isolated in 2003 and 2008 revealed a significantly higher frequency of O:11 serogroup than other serogroups. Meanwhile, in the group of nonmultidrug-resistant P. aeruginosa strains, P. aeruginosa O:11 serogroup strains were identified less frequently and accounted only for 2.8% (n=2, P<0.001) of the isolates in 2003 and 27.6% (n=21, P<0.01) in 2008. Conclusions. During the 5-year period, the isolation rate of P. aeruginosa strains belonging to serogroup O:11 increased. P. aeruginosa strains isolated in 2003 and 2008 belonging to serogroup O:11 were more frequently multidrug resistant. The increasing resistance of P. aeruginosa to reserve antibiotics of carbapenem group was observed.
Analysis of Body Composition of 9- and 10-Year-Old Children in Latvia
Authors: Karklina Helena , Apinis Peteris , Kalnina Liga , Sauka Melita , Mozgis Dzintars , Krumina Dzanna , Knipse Gundega
Published: April 2018

Background and Objective. According to the data of epidemiologic research, the prevalence of both excessive and insufficient body weight is increasing in a pediatric population leading to the growing burden of health problems due to these changes. The aim of the study was to understand the current situation of physical development of 9- and 10-year-old boys and girls in Latvia and to estimate the prevalence of underweight, normal weight, overweight, and obesity among young adolescents. Material and Methods. During 2007–2009, a random sample of healthy 9-year-old (n=184) and 10-year-old (n=320) children from all regions and different socioeconomic groups of Latvia was surveyed in a cross-sectional study. The anthropometric measurements of height, weight, 3 circumferences, and 5 skinfolds were performed. The percentage of body fat was calculated by the equation of Slaughter et al. Body mass index and fat mass index were calculated for each respondent. Children were divided into groups according to these indexes. At the age of 9 years, 69.5% of boys had a normal nutritional level either by BMI or FMI, and 54.5% and 72.2% of the girls of the same age had a normal nutritional level by BMI and by FMI, respectively. Obesity according to BMI in 9-year-old boys was found to be 4.7% and in girls 6.1%; according to FMI, 3.7% and 2.3%, respectively. A similar trend was also observed in the cohort of 10-year-old children. Conclusions. The results of the research showed that the problem of high prevalence of Latvian children with underweight is not smaller than the problem of children with obesity. Evaluation of physical development in children based only body mass index may lead to overdiagnosis of obesity.
Pharmaceutical Care as Described by Home-Dwelling Older People in Finland
Authors: Eloranta Sini , Hannukainen Sanna , Routasalo Pirkko , Viitanen Matti , Arve Seija
Published: April 2018

Background and Objective. Pharmaceutical care is one of the most important therapeutic tools in older people care. The aim of this study was to describe the knowledge and attitudes of older home-dwelling people’s about their perceptions of pharmaceutical care and use of medication. Material and Methods. The data were collected using theme interviews with 16 older Finnish people (born 1920). Inductive content analysis was used in analyzing the data. Results. Older people’s knowledge about their pharmaceutical care varied widely: some had precise knowledge whereas others had none. Guidance in pharmaceutical care was not readily available. The interviewees took a positive attitude toward their pharmaceutical care and favored a minimum use of medication. Being able to cope independently with their pharmaceutical care strengthened the older people’s sense of control over their lives. Conclusions. The study offers new knowledge about the significance of older people’s individual pharmaceutical care at home. By listening to and utilizing older people’s experiences, we can recognize the factors that promote the independent coping and inclusion of older people in their pharmaceutical care. This enables health care providers to increase the safety and quality of pharmaceutical care for older people.
Diet and Dyslipidemias in a Lithuanian Rural Population Aged 25-64: the CINDI Survey
Authors: Petkevičienė Janina , Klumbienė Jūratė , Ramažauskienė Vitalija , Kriaučionienė Vilma , Edita  , Grabauskas Vilius
Published: April 2018

The aim of the study was to evaluate the dietary intake of a Lithuanian rural population and to assess the relationship between diet and dyslipidemias. Material and Methods. A cross-sectional health survey was carried out in 5 municipalities of Lithuania in 2007. The random sample was obtained from lists of 25- to 64-year-old inhabitants registered at primary health care centers (n=1739). The food frequency questionnaire and 24-hour recall was used for the evaluation of nutrition habits. The levels of serum lipids were determined using enzymatic methods. Factor analysis was employed in order to reduce the number of food items. The scores of food factors were used in linear regression analysis of associations between nutrition and serum lipid levels. Results. The diet of the study population was very high in fat, especially in saturated fatty acids. The content of cholesterol in the diet of men was higher than recommended. The main sources of fat and protein were meat, milk, and their products. Cereals were the main source of carbohydrates. The major proportion of monosaccharide and disaccharides was derived from confectionary and fruits. The mean serum total cholesterol level was 5.60 mmol/L in men and 5.51 mmol/L in women. Conclusions. Healthier food patterns were associated with the lower levels of total, low-density lipoprotein cholesterol, and triglyceride.
Effect of Single Physical Load of Different Duration and Intensity on Cognitive Function
Authors: Sipavičienė Saulė , Dumčienė Audronė , Ramanauskienė Irina , Skurvydas Albertas
Published: April 2018

The aim of this study was to determine the effect of a single physical load of different duration and intensity on cognitive function. Material and Methods. The study population comprised 90 male soldiers. The subjects were randomly divided into two groups: experimental (n=60) and control group (n=30). The soldiers in the experimental group undertook 3 specific loads of different types, durations, and intensities. Attention concentration and tapping tests were carried out, and the reaction time was measured. Results. After the physical load, the soldiers in the experimental group performed the attention concentration test faster, the number of committed mistakes decreased, and the rate of processing information increased as compared to the corresponding values before physical load (all P<0.05). However, the indices of fatigue, such as the tapping test score and reaction time, in the experimental group were found to be worse than before physical loads (P<0.05). No significant changes were observed in the control group of soldiers. Conclusion. Despite fatigue, a single physical load of different duration and intensity improved the cognitive function.
Concentrations of Thyroid Axis Hormones in Psychotic Patients on Hospital Admission: the Effects of Prior Drug Use
Authors: Steiblienė Vesta , Mickuvienė Narseta , Prange Arthur , Bunevičius Robertas
Published: April 2018

The aim of this study was to determine the concentrations of thyroid axis hormones in psychotic patients on hospital admission and to search for the associations between the concentrations of these hormones and prior drug use as well as mental symptoms. Material and Methods. Psychiatric diagnoses, psychotropic drug use, and the severity of psychoses were evaluated using the standard methods on admission. Venous blood from patients and healthy controls was drawn for the analysis of free thyroxin (FT4), free triiodothyronine (FT3), thyroid-stimulating hormone (TSH), and sex hormone-binding globulin (SHBG) concentrations. Results. Eighty-one psychotic patients, free of a thyroid disorder, were enrolled into the study. Compared with the controls, they displayed the higher FT4 concentrations in the general group (P=0.003) and the higher SHBG concentrations only in men (P=0.013). The FT4 concentration was higher in the patients who were not taking an antipsychotic drug on admission (P=0.039). No significant correlation was found between the severity of psychosis and concentrations of thyroid axis hormones. However, the FT3 concentration in the general group and TSH concentration in women correlated with the factor of the Brief Psychiatric Rating Scale expressing elevated mood. Conclusions. Our study confirms the higher FT4 concentrations in a significant proportion of acute psychotic patients. The concentrations of thyroid axis hormones were found to be associated with prior antipsychotic treatment on hospital admission.
An Unusual Case of a Sore Throat and Otalgia in a 4-Year-Old Boy
Authors: Šiupšinskienė Nora , Padervinskis Evaldas , Poškienė Lina , Endeley Nganjo , Vaitkus Saulius
Published: April 2018

A sore throat, otalgia, and snoring are the common symptoms seen in children presenting to an otorhinolaryngological clinic. Sometimes, however, these symptoms may be suggestive of an aggressive malignancy. We present a rare case of Burkitt’s lymphoma of the tonsil in a young child, which initially manifested as a sore throat and otalgia.
Volumetric MRI Assessment of Brain and Spinal Cord in Finnish Twins Discordant for Multiple Sclerosis
Authors: Kuusisto Hanna , Wu Xingchen , Dastidar Prasun , Luukkaala Tiina , Elovaara Irina
Published: April 2018

Background and Objective. Brain size, white matter hyperintensity, and the development of brain atrophy are known to be highly heritable. The decrease of brain volume starts from the very onset of multiple sclerosis and is 10-fold compared with normal aging. The aim of this study was to assess whether the brain and spinal cord volumes and the volume of white matter lesions differed between twins with multiple sclerosis and their asymptomatic co-twins. Material and Methods. A co-twin control method was used to evaluate whether the brain and spinal cord volumes differ between twins with multiple sclerosis and their co-twins. Nineteen twin pairs were studied neurologically, and the volumes of T1, T2, FLAIR, and gadolinium-enhanced lesions and those of the brain and the spinal cord were obtained by magnetic resonance imaging. Results. Significant differences in the brain (P=0.064) or spinal cord (P=0.648) volumes were not detected. Four of the 7 monozygotic and 5 of the 12 dizygotic co-twins had focal brain white matter lesions, but none fulfilled the magnetic resonance imaging criteria of Barkhof. Spinal cord lesions were not seen in any of the co-twins. Conclusions. The absence of a significant difference in the brain or spinal cord volume between the twins with multiple sclerosis and their co-twins supports the recent observation of brain size and the development of brain atrophy being highly heritable.
Burnout among Lithuanian Cardiac Surgeons and Cardiac Anesthesiologists
Authors: Mikalauskas Audrius , Širvinskas Edmundas , Marchertienė Irena , Macas Andrius , Samalavičius Robertas , Kinduris Šarūnas , Benetis Rimantas
Published: April 2018

Objective. The aim of this study was to determine the prevalence of burnout among Lithuanian cardiac surgeons and cardiac anesthesiologists, and associations between burnout and the personal and professional characteristics of physicians. Material and Methods. A total of 29 cardiac surgeons and 30 cardiac anesthesiologists employed in Vilnius and Kaunas university hospitals as well as in Klaipėda Hospital were surveyed. Data on personal characteristics (age, gender, marital status, number of children, sleeping hours, and addictions), professional characteristics (years in practice, work character, work profile, and workload), career satisfaction, and symptoms of depression were collected by using an anonymous questionnaire. Burnout was measured by the Maslach Burnout Inventory-Human Services Survey (MBI-HSS). Results. More than half (54.3%) of the physicians surveyed had been in practice for >15 years, 71.2% reported working more than 40 hours per week, and 62% reported of being burned out. As much as 19.3% of physicians reported high emotional exhaustion, 25.9% had high depersonalization, and 42.3% demonstrated low personal accomplishment at work. Nearly 95% of respondents would become a physician and 82.8% would choose to become a cardiac surgeon or a cardiac anesthesiologist again. Physicians who worked more than 40 hours per week, smokers, and those who were desperate were more likely to be burned out. Conclusions. Burnout was found to be prevalent among Lithuanian cardiac surgeons and cardiac anesthesiologists. Some personal and professional characteristics were significantly related to burnout. Burnout relief measures should be developed in order to prevent a further increase of burnout syndrome among Lithuanian cardiac surgeons and cardiac anesthesiologists.
Strength Development and Microstructure Evolution of Cemented Tailings Backfill Containing Different Binder Types and Contents
Authors: Xu Wenbin , Cao Peiwang , Tian Mingming
Published: April 2018

The microstructure evolution and strength development of cemented tailings backfill (CTB), mixed with plant tailings and cement, is critical to a more thorough and complete understanding of its functionality as a support structure in underground mining operations. Here, an experimental study is conducted to investigate the effect of the solid contents of tailings, binder proportion, and type of cement reagent on unconfined compressive strength (UCS) and microstructure evolution with respect to a 90-day curing time. The results indicate that the mechanical strength gain is proportionally associated with increased binder and solid content. Besides, the samples prepared with 70 wt % solid content and a 25 wt % binder/tailings ratio have a maximum UCS of 6.26 MPa at a curing time of 90 days. In addition, it is also concluded that the binder proportion promotes the strength acquisition of CTB samples. Specifically, the 90-day UCS of the CTB with solid content of 68 wt % and binder content of 25 wt % is approximately twice that of the CTB with a 12.5 wt % binder proportion. Slag cement (Binder B1) and slag cement with 5 wt % NaOH (Binder B2) are used as admixture to replace the cement reagent; the results show that Binder B2 has more advantages than Binder B1 and Portland cement, and is a suitable cementing material for the CTB technology in the Daye Iron Mine. The microstructure is dominated by the network of hydration products and distribution of the pore, and hydrated material is significantly influenced by the curing time. The tailings particles are enclosed by the hydration products, and randomly disperse within their matrix at curing time of 90 days. Finally, the UCSs of CTB samples are observed to significantly increase with the increase in the curing time.
Two Novel Cycloartane-Type Triterpenes from Trichilia casaretti C. DC. (Meliaceae)
Authors: Vieira Ivo Jose Curcino , Figueiredo Elaine Rodrigues , Vieira Milena Gonçalves Curcino , Carvalho Junior Almir Ribeiro de , Passos Michel de Souza , Boeno Samyra Imad da Silva , Azevedo Otoniel Aquino , Braz-Filho Raimundo
Published: April 2018

Two new triterpenes cycloartane-type, named 24-methylencycloartan-12-oxo-3β,22α-diol and trichiliol, were isolated from the leaves of Trichilia casaretti C. DC. together with three known triterpenes—24-methylencycloart-3β,22-diol, 22,25-dihydrocycloart-23(E)-en-3β-ol, and 22(R)-hydroxycycloart-24-en-3-ol. These compounds were characterized on the basis of their spectral data, mainly 1D (1H and 13C) and 2D NMR (1H-1H-COSY, 1H-1H-NOESY, HMQC, HSQC, and HMBC), and mass spectra (EI-MS and HR-ESI-MS), also involving comparison with data from the literature.
Search for Partner Proteins of A. thaliana Immunophilins Involved in the Control of Plant Immunity
Authors: Abdeeva Inna A. , Pogorelko Gennady V. , Maloshenok Liliya G. , Mokrykova Maria V. , Fursova Oksana V. , Bruskin Sergey A.
Published: April 2018

The involvement of plant immunophilins in multiple essential processes such as development, various ways of adapting to biotic and abiotic stresses, and photosynthesis has already been established. Previously, research has demonstrated the involvement of three immunophilin genes (AtCYP19-1/ROC3, AtFKBP65/ROF2, and AtCYP57) in the control of plant response to invasion by various pathogens. Current research attempts to identify host target proteins for each of the selected immunophilins. As a result, candidate interactors have been determined and confirmed using a yeast 2-hybrid (Y2H) system for protein–protein interaction assays. The generation of mutant isoforms of ROC3 and AtCYP57 harboring substituted amino acids in the in silico-predicted active sites became essential to achieving significant binding to its target partners. This data shows that ROF2 targets calcium-dependent lipid-binding domain-containing protein (At1g70790; AT1) and putative protein phosphatase (At2g30020; АТ2), whereas ROC3 interacts with GTP-binding protein (At1g30580; ENGD-1) and RmlC-like cupin (At5g39120). The immunophilin AtCYP57 binds to putative pyruvate decarboxylase-1 (Pdc1) and clathrin adaptor complex-related protein (At5g05010). Identified interactors confirm our previous findings that immunophilins ROC3, ROF2, and AtCYP57 are directly involved with stress response control. Further, these findings extend our understanding of the molecular functional pathways of these immunophilins.
Formation of Sulforaphane and Iberin Products from Thai Cabbage Fermented by Myrosinase-Positive Bacteria
Authors: Luang-In Vijitra , Deeseenthum Sirirat , Udomwong Piyachat , Saengha Worachot , Gregori Matteo
Published: April 2018

Myrosinase-positive bacteria from local fermented foods and beverages in Thailand with the capacity to metabolize glucosinolate and produce isothiocyanates (ITCs) were isolated and used as selected strains for Thai cabbage fermentation. Enterobacter xiangfangensis 4A-2A3.1 (EX) from fermented fish and Enterococcus casseliflavus SB2X2 (EC) from fermented cabbage were the two highest ITC producers among seventeen strains identified by 16S rRNA technique. EC and EX were used to ferment Thai cabbage (Brassica oleracea L. var. capitata) containing glucoiberin, glucoraphanin and 4-hydroxyglucobrassicin at 430.5, 615.1 and 108.5 µmol/100 g DW, respectively for 3 days at 25 °C. Different amounts of iberin nitrile, iberin, sulforaphane and indole 3-acetonitrile were produced by spontaneous, EX- and EC-induced cabbage fermentations, and significantly higher ITCs were detected (p < 0.01) with increased antioxidant activities. Iberin and sulforaphane production in EX-induced treatment peaked on day 2 at 117.4 and 294.1 µmol/100 g DW, respectively, significantly higher than iberin at 51.7 µmol/100 g DW but not significantly higher than sulforaphane at 242.6 µmol/100 g DW in EC-induced treatment at day 2. Maximum health-promoting benefits from this functional food can be obtained from consumption of a liquid portion of the fermented cabbage with higher ITC level along with a solid portion.
HIV Resistance Prediction to Reverse Transcriptase Inhibitors: Focus on Open Data
Authors: Tarasova Olga , Poroikov Vladimir
Published: April 2018

Research and development of new antiretroviral agents are in great demand due to issues with safety and efficacy of the antiretroviral drugs. HIV reverse transcriptase (RT) is an important target for HIV treatment. RT inhibitors targeting early stages of the virus-host interaction are of great interest for researchers. There are a lot of clinical and biochemical data on relationships between the occurring of the single point mutations and their combinations in the pol gene of HIV and resistance of the particular variants of HIV to nucleoside and non-nucleoside reverse transcriptase inhibitors. The experimental data stored in the databases of HIV sequences can be used for development of methods that are able to predict HIV resistance based on amino acid or nucleotide sequences. The data on HIV sequences resistance can be further used for (1) development of new antiretroviral agents with high potential for HIV inhibition and elimination and (2) optimization of antiretroviral therapy. In our communication, we focus on the data on the RT sequences and HIV resistance, which are available on the Internet. The experimental methods, which are applied to produce the data on HIV-1 resistance, the known data on their concordance, are also discussed.