bluuebunny/crossref_metadata_2025 huggingface dataset:
AgNP Composite Silicone-Based Polymer Self-Healing Antifouling Coatings
Authors: Liu Xingda , Sun Jiawen , Duan Jizhou , Sui Kunyan , Zhai Xiaofan , Zhao Xia
Published: August 2024

Biofouling poses a significant challenge to the marine industry, and silicone anti-biofouling coatings have garnered extensive attention owing to their environmental friendliness and low surface energy. However, their widespread application is hindered by their low substrate adhesion and weak static antifouling capabilities. In this study, a novel silicone polymer polydimethylsiloxane (PDMS)-based poly(urea-thiourea-imine) (PDMS-PUTI) was synthesized via stepwise reactions of aminopropyl-terminated polydimethylsiloxane (APT-PDMS) with isophorone diisocyanate (IPDI), isophthalaldehyde (IPAL), and carbon disulfide (CS2). Subsequently, a nanocomposite coating (AgNPs-x/PDMS-PUTI) was prepared by adding silver nanoparticles (AgNPs) to the polymer PDMS-PUTI. The dynamic multiple hydrogen bonds formed between urea and thiourea linkages, along with dynamic imine bonds in the polymer network, endowed the coating with outstanding self-healing properties, enabling complete scratch healing within 10 min at room temperature. Moreover, uniformly dispersed AgNPs not only reduced the surface energy of the coating but also significantly enhanced its antifouling performance. The antibacterial efficiency against common marine bacteria Pseudomonas aeruginosa (P.sp) and Staphylococcus aureus (S.sp) was reduced by 97.08% and 96.71%, respectively, whilst the diatom settlement density on the coating surface was as low as approximately 59 ± 3 diatom cells/mm2. This study presents a novel approach to developing high-performance silicone antifouling coatings.
The Application of Converter Sludge and Slag to Produce Ecological Cement Mortars
Authors: Ulewicz Malgorzata , Jura Jakub , Zieliński Adam , Pietraszek Jacek
Published: August 2024

The paper presents an analysis of the effective use of a mixture of steel sludge (S1) and slag (S2) from the converter process of steel production for the production of cement mortars. Metallurgical waste used in the research, which is currently deposited in waste landfills and heaps near plants, posing a threat to groundwater (possibility of leaching metal ions present in the waste), was used as a substitute for natural sand in the range of 0–20% by weight of cement (each). The obtained test results and their numerical analysis made it possible to determine the conditions for replacing part of the sand in cement mortars with a mixture of sludge and slag from a basic oxygen furnace (BOF) and to determine the effects of such modification. For the numerical analysis, a full quadratic Response Surface Model (RSM) was utilized for two controlled factors. This model was subsequently optimized through backward stepwise regression, ensuring the inclusion of only statistically significant components and verifying the consistency of residual distribution with the normal distribution (tested via Ryan-Joiner’s test, p > 0.1). The designated material models are helpful in designing ecological cement mortars using difficult-to-recycle waste (i.e., sludge and converter slag), which is important for a circular economy. Mortars modified with a mixture of metallurgical waste (up to 20% each) are characterized by a slightly lower consistency, compressive and flexural strength, and water absorption. However, they show a lower decrease in mechanical strength after the freezing–thawing process (frost resistance) compared to control mortars. Mortars modified with metallurgical waste do not have a negative impact on the environment in terms of leaching heavy metal ions. The use of a mixture of sludge and steel slag in the amount of 40% (slag/sludge in a 20/20 ratio) allows you to save 200 kg of sand when producing 1 m3 of cement mortar (cost reduction by approx. EUR 5.1/Mg) and will also reduce the costs of the environmental fee for depositing waste.
Dentin Bonding Durability of Four Different Recently Introduced Self-Etch Adhesives
Authors: Kitahara Sayaka , Shimizu Shojiro , Takagaki Tomohiro , Inokoshi Masanao , Abdou Ahmed , Burrow Michael F. , Nikaido Toru
Published: August 2024

The objectives of this study were to evaluate the bonding durability of four different self-etch adhesives to dentin after 24 h and thermal cycling (TC) and to measure the degree of polymerization conversion (DC) in situ. Two-step self-etch adhesives, Clearfil SE Bond 2 (SE2, Kuraray Noritake Dental) and G2-Bond Universal (G2B, GC), and one-step self-etch adhesives, Scotchbond™ Universal Plus Adhesive (SBU, 3M ESPE) and Clearfil Universal Bond Quick (UBQ, Kuraray Noritake Dental), were used. The labial surfaces of bovine teeth were ground to create flat dentin surfaces. The adhesives were applied according to the manufacturers’ instructions. After resin composite buildup and 24 h water storage, the specimens were sectioned into beams and all groups were subjected to thermal stress for 0, 10,000 (10k), or 20,000 (20k) cycles followed by micro-tensile bond strength (µTBS) testing. In situ DC was investigated with a laser Raman microscope. The µTBS data were statistically analyzed and subjected to a Weibull analysis. The different groups were compared at the characteristic strength (63.2% probability of failure) (α = 0.05). Two-Way ANOVA was used to show the effect of different adhesives and thermal cycling on the mean DC% followed by Tukey’s multiple comparison post hoc test. G2B/TC10k resulted in a significant increase in the µTBS compared to TC0. SBU/TC20k showed significantly higher µTBS compared to TC0. For comparison between different tested adhesives, SBU showed a significantly lower µTBS compared to G2B after TC10k. G2B and SBU showed a greater number of adhesive failures after TC. Mean DC% was different for each adhesive. The newly developed MDP- and HEMA-free 2-SEA showed similar bonding performance with the gold-standard 2-SEA. However, there is still room for further improvement in terms of SEAs.
Realization of Joints of Aluminosilicate Glass and 6061 Aluminum Alloy via Picosecond Laser Welding without Optical Contact
Authors: Tan Caiwang , Lu Xing , Liu Fuyun , Song Wei , Guo Guanghui , Li Qige , Liu Yuhang , Su Jianhui , Song Xiaoguo
Published: August 2024

To achieve laser direct welding of glass and metal without optical contact is hard, owing to the large difference in thermal expansion and thermal conductivity between glass and metal and an insignificant melting area. In this study, the high-power picosecond pulsed laser was selected to successfully weld the aluminosilicate glass/6061 aluminum alloy with a gap of 35 ± 5 μm between glass and metal. The results show that the molten glass and metal diffuse and mix at the interface. No defects such as microcracks or holes are observed in the diffusion mixing zone. Due to the relatively large gap, the glass collapsed after melting and caulking, resulting in an approximately arc-shaped microcrack between modified glass and unmodified glass or weakly modified glass. The shape of the glass modification zone and thermal accumulation are influenced by the single-pulse energy and linear energy density of the picosecond laser during welding, resulting in variations in the number and size of defects and the shape of the glass modification zone. By reasonably tuning the two factors, the shear strength of the joint reaches 15.98 MPa. The diffusion and mixing at the interface and the mechanical interlocking effect of the glass modification zone are the main reasons for achieving a high shear strength of the joint. This study will provide reference and new ideas for the laser transmission welding of glass and metal in the non-optical contact conditions.
Development of Sustainable Construction Materials from Inert Waste Mixtures Using the Mechanosynthesis Process
Authors: Hamzaoui Rabah , Bouchenafa Othmane , Idir Rachida , Djerbi Assia , Fen-Chong Teddy , Florence Céline , Boutin François
Published: August 2024

This research investigates the potential of mechanosynthesis to transform inert waste mixtures into sustainable construction materials. Three waste streams were employed: recycled glass, recycled concrete, and excavated soils. Two alternative material formulations, F1 (50% recycled concrete, 30% recycled glass, 20% excavated soil) and F2 (60% excavated soil, 20% recycled concrete, 20% recycled glass), were developed. Cement pastes were produced by partially substituting cement (CEM I) with 50% of either F1 or F2. Characterization techniques, including X-ray diffraction (XRD), Fourier transform infrared spectroscopy (ATR-FTIR), and mechanical testing, were performed. Cement pastes incorporating milled waste materials exhibited significantly enhanced compressive strength compared to their unmilled counterparts. At 28 curing days, compressive strengths reached 44, 47, 45, and 49.7 MPa, and at 90 curing days, they increased to 47.5, 50, 55, and 61 MPa for milling conditions of 200 rpm for 5 min, 200 rpm for 15 min, 400 rpm for 5 min, and 400 rpm for 15 min, respectively. In addition, F1 formulations showed higher compressive strengths than the reference CEM II and CEM III pastes. These results highlight the efficacy of mechanosynthesis in valorizing construction waste, mitigating CO2 emissions, and creating environmentally friendly construction materials.
Mechanical and Fatigue Properties of Welded Fe-Mn-Si Shape Memory Alloys
Authors: Hong Kinam , Ji Sangwon , Kim Dohyung , Bae Jinyoung
Published: August 2024

This paper presents the experimental results of a study evaluating the mechanical and fatigue performance of welded Fe-Mn-Si SMA. For the experimental study, welded and welded-and-heat-treated Fe-Mn-Si SMA specimens were fabricated, and fatigue tests were performed at various stress amplitudes. In addition, direct tensile tests and recovery stress tests were also performed to evaluate the material properties of Fe-Mn-Si SMAs. The elastic modulus, yield strength, and tensile strength of the welded specimens were reduced by 35.4%, 12.1%, and 8.6%, respectively, compared to the values of the non-welded specimens. On the other hand, the elastic modulus, yield strength, and tensile strength of the welded-and-heat-treated Fe-Mn-Si SMA specimens were increased by 18.6%, 4.9%, and 1.3%, respectively, compared to the values of the welded specimens. Both welded and welded-and-heat-treated Fe-Mn-Si SMAs failed at lower cycles than the conventional Fe-Mn-Si SMAs at the same stress amplitude. High-cycle fatigue failure, characterized by cycles exceeding 104, typically occurs at relatively low stress levels within the elastic region, whereas low-cycle fatigue failure, generally occurring within cycles below 104, involves high stress levels that encompass both elastic and plastic deformation. Regardless of the welding condition, the stress amplitude at which Fe-Mn-Si SMA transitions from high-cycle to low-cycle failure exceeded the yield strength.
Influences of Pre-Existing Fissure Angles and Bridge Angles on Concrete Tensile Failure Characteristics: Insights from Meshless Numerical Simulations
Authors: Hu Cong , Li Taicheng , Fu Zhaoqing , Mao Haiying , Wang Siyao , Liang Zilin , Yu Shuyang
Published: August 2024

The existence of cracks is a key factor affecting the strength of concrete. However, traditional numerical methods still have some limitations in the simulation of crack growth in fissured concrete structures. Based on this background, the numerical treatment method of particle failure in smoothed particle hydrodynamics (SPH) is proposed, and the generation method for concrete meso-structures under the smoothed particle hydrodynamics (SPH) framework is developed. The concrete meso-models under different pre-existing micro-fissure inclinations and bridge angles (the inner tip line of the double pre-existing micro-fissure is defined as a bridge, and the angle between the bridge and the horizontal direction is defined as the bridge angle) were established, and numerical simulations of the crack propagation processes of concrete structures under tensile stress were carried out. The main findings were as follows: The concrete meso-structures and the pre-existing micro-fissures all have great impacts on the final failure modes of concrete. The stress–strain curve of the concrete model presents four typical stages. Finally, the crack initiation and propagation mechanisms of fissured concrete are discussed, and the application of smoothed particle hydrodynamics (SPH) in crack simulations of fissured concrete is prospected.
Enhanced Activation in Phosphorous-Doped Silicon via Dual-Beam Laser Annealing
Authors: Taiwo Rasheed Ayinde , Son Yeongil , Shin Joonghan , Salawu Yusuff Adeyemi
Published: August 2024

In this study, we conduct a comparative analysis of single-beam laser annealing (SBLA) and dual-beam laser annealing (DBLA) techniques for semiconductor manufacturing. In the DBLA approach, two laser beams were precisely aligned to simultaneously heat a phosphorus-doped silicon (Si) wafer. The main objective was to investigate the impact of the two annealing techniques on the electrical properties, crystalline structure, and diffusion profile of the treated phosphorus-doped Si at equivalent laser powers. Both SBLA and DBLA improved the electrical properties of the phosphorus-doped Si, evidenced by increased carrier concentration and reduced carrier mobility. Additionally, the crystalline structure of the phosphorus-doped Si showed favorable modifications, with no defects and improved crystallinity. While both SBLA and DBLA produced similar phosphorus profiles with no significant redistribution of dopants compared to the as-implanted sample, DBLA achieved a higher activation ratio than SBLA. Although the results suggest improved dopant activation with minimal diffusion, further studies are needed to clearly confirm the effect of DBLA on dopant activation and diffusion.
Change in Surface Roughness on the Inner and Outer Surfaces of the Microtube during Hollow Sinking
Authors: Sakaguchi Hayate , Kishimoto Takuma , Suematsu Saki , Tashima Kenichi , Kano Koichi , Kajino Satoshi , Gondo Shiori , Suzuki Shinsuke
Published: August 2024

Hollow sinking experiments and tensile tests were conducted to clarify the evolution of surface roughness during hollow sinking. Stainless steel tubes (outer diameter: 1.5 mm; wall thickness: 0.045 mm) featuring a single grain spanning the wall thickness achieved via annealing as the starting material. The tube was drawn without an internal tool using a draw bench by controlling the tube drawing speed ratio of the die entrance and exit sides. The surface roughnesses of the inner and outer surfaces at the die entrance and exit sides of the drawn tube were compared with the surface roughnesses of the inner and outer surfaces under the uniaxial tensile deformation of the starting material. As a result, two major findings were revealed; the surface roughness formation behavior during the hollow sinking; the uniaxial tensile deformation exhibits a tube on both sides of the entrance and the exit of a die. Former uniaxial tensile deformation forms surface roughness of the tube at the die-entrance-side. However, hollow sinking reduces the roughness. The tube keeps its small roughness even though it is applied the later uniaxial tensile deformation behind the die exit. Furthermore, the conventional formula to predict the surface roughness of a metal sheet caused by the uniaxial tensile deformation can predict the surface roughness of a tube in the hollow sinking. At both die entrance and exit sides, the roughness of the inner surface was larger than that of the outer surface at the die entrance and exit side. The outer surface of the tube contacts the inside of a die when the tube passes through the die. The height of the convex parts decreased at that moment. Hollow sinking suppressed the increase in surface roughness of the inner surface as the outer surface was smoothed in the die. However, due to the formation of surface roughness after leaving the die, there is an overall increasing trend in inner surface roughness.
Decentralized Adaptive Event-Triggered Fault-Tolerant Cooperative Control of Multiple Unmanned Aerial Vehicles and Unmanned Ground Vehicles with Prescribed Performance under Denial-of-Service Attacks
Authors: Liu Shangkun , Huang Jie
Published: August 2024

This paper proposes a decentralized adaptive event-triggered fault-tolerant cooperative control (ET-FTCC) scheme for multiple unmanned aerial vehicles (UAVs) and unmanned ground vehicles (UGVs) with actuator faults and external disturbances under denial-of-service (DoS) attacks. The multiple UAVs and UGVs have a larger search radius, which is important in both the civilian and military domains. The different dynamics between UAVs and UGVs result in unbalanced interactions in the communication topologies, which increases the complexity of cooperative control. DoS attacks are conducted in both sensor and control channels. The dynamic models of UAVs and UGVs are introduced firstly, and the unified heterogeneous multiagent system model with actuator faults is established. The composite observer is designed to obtain the information of state and lumped disturbance, which is used to design the controller. In order to save the limited communication network resources, the event-triggered mechanism is introduced. The transformed error is presented by using the prescribed performance function (PPF). Then, the sliding-mode manifold is presented by combining the event-triggered control scheme to achieve the tracking purpose with actuator faults, external disturbances, and DoS attacks. Based on the Lyapunov function approach, the tracking errors are bounded within the prescribed boundary. Finally, the effectiveness of the proposed method is verified by qualitative analysis and quantitative analysis of the simulation results. This study can enhance the security and reliability of heterogeneous multiagent systems, providing technical support for the safe operation of unmanned systems. This paper mainly solves the FTCC problem of second-order nonlinear heterogeneous multiagent systems, and further research is needed for the FTCC problem of higher-order nonlinear heterogeneous multi-agent systems. In addition, the system may encounter multiple cyber attacks. As one of the future research works, we can extend the results of this paper to high-order nonlinear systems under multiple cyber attacks, which contain DoS attacks and deception attacks, and achieve fault-tolerant cooperative control of heterogeneous multiagent systems.
Inverse-Positive Matrices and Stability Properties of Linear Stochastic Difference Equations with Aftereffect
Authors: Ponosov Arcady , Kadiev Ramazan I.
Published: August 2024

This article examines the stability properties of linear stochastic difference equations with delays. For this purpose, a novel approach is used that combines the theory of inverse-positive matrices and the asymptotic methods developed by N.V. Azbelev and his students for deterministic functional differential equations. Several efficient conditions for p-stability and exponential p-stability (2≤p<∞) of systems of linear Itô-type difference equations with delays and random coefficients are found. All results are conveniently formulated in terms of the coefficients of the equations. The suggested examples illustrate the feasibility of the approach.
Zhang Neuro-PID Control for Generalized Bi-Variable Function Projective Synchronization of Nonautonomous Nonlinear Systems with Various Perturbations
Authors: Huang Meichun , Zhang Yunong
Published: August 2024

Nonautonomous nonlinear (NN) systems have broad application prospects and significant research value in nonlinear science. In this paper, a new synchronization type—namely, generalized bi-variable function projective synchronization (GBVFPS)—is proposed. The scaling function matrix of GBVFPS is not one-variable but bi-variable. This indicates that the GBVFPS can be transformed into various synchronization types such as projective synchronization (PS), modified PS, function PS, modified function PS, and generalized function PS. In order to achieve the GBVFPS in two different NN systems with various perturbations, by designing a novel Zhang neuro-PID controller, an effective and anti-perturbation GBVFPS control method is proposed. Rigorous theoretical analyses are presented to prove the convergence performance and anti-perturbation ability of the GBVFPS control method, especially its ability to suppress six different perturbations. Besides, the effectiveness, superiority, and anti-perturbation ability of the proposed GBVFPS control method are further substantiated through two representative numerical simulations, including the synchronization of two NN chaotic systems and the synchronization of two four-dimensional vehicular inverted pendulum systems.
Two C23-Steroids and a New Isocoumarin Metabolite from Mangrove Sediment-Derived Fungus Penicillium sp. SCSIO 41429
Authors: Huang Lishan , Chen Chunmei , Cai Jian , Chen Yixin , Zhu Yongyan , Yang Bin , Zhou Xuefeng , Liu Yonghong , Tao Huaming
Published: August 2024

Two new C23-steroids derivatives, cyclocitrinoic acid A (1) and cyclocitrinoic acid B (2), and a new isocoumarin metabolite, (3R,4S)-6,8-dihydroxy-3,4,5-trimethyl-7-carboxamidelisocoumarin (10), together with 12 known compounds (3–9, 11–15) were isolated from the mangrove-sediment fungus Penicillium sp. SCSIO 41429. The structures of the new compounds were comprehensively characterized by 1D and 2D NMR, HRESIMS and ECD calculation. All isolates were evaluated for pancreatic lipase (PL) inhibitory and antioxidant activities. The biological evaluation results revealed that compounds 2, 14 and 15 displayed weak or moderate inhibition against PL, with IC50 values of 32.77, 5.15 and 2.42 µM, respectively. In addition, compounds 7, 12 and 13 showed radical scavenging activities against DPPH, with IC50 values of 64.70, 48.13, and 75.54 µM, respectively. In addition, molecular docking results indicated that these compounds had potential for PL inhibitory and antioxidant activities, which provided screening candidates for antioxidants and a reduction in obesity.
Bioactive Glial-Derived Neurotrophic Factor from a Safe Injectable Collagen–Alginate Composite Gel Rescues Retinal Photoreceptors from Retinal Degeneration in Rabbits
Authors: Hu Tingyu , Zhou Ting , Goit Rajesh Kumar , Tam Ka Cheung , Chan Yau Kei , Lam Wai-Ching , Lo Amy Cheuk Yin
Published: August 2024

The management of vision-threatening retinal diseases remains challenging due to the lack of an effective drug delivery system. Encapsulated cell therapy (ECT) offers a promising approach for the continuous delivery of therapeutic agents without the need for immunosuppressants. In this context, an injectable and terminable collagen–alginate composite (CAC) ECT gel, designed with a Tet-on pro-caspase-8 system, was developed as a safe intraocular drug delivery platform for the sustained release of glial-cell-line-derived neurotrophic factor (GDNF) to treat retinal degenerative diseases. This study examined the potential clinical application of the CAC ECT gel, focusing on its safety, performance, and termination through doxycycline (Dox) administration in the eyes of healthy New Zealand White rabbits, as well as its therapeutic efficacy in rabbits with sodium-iodate (SI)-induced retinal degeneration. The findings indicated that the CAC ECT gel can be safely implanted without harming the retina or lens, displaying resistance to degradation, facilitating cell attachment, and secreting bioactive GDNF. Furthermore, the GDNF levels could be modulated by the number of implants. Moreover, Dox administration was effective in terminating gel function without causing retinal damage. Notably, rabbits with retinal degeneration treated with the gels exhibited significant functional recovery in both a-wave and b-wave amplitudes and showed remarkable efficacy in reducing photoreceptor apoptosis. Given its biocompatibility, mechanical stability, controlled drug release, terminability, and therapeutic effectiveness, our CAC ECT gel presents a promising therapeutic strategy for various retinal diseases in a clinical setting, eliminating the need for immunosuppressants.
Stonikacidin A, an Antimicrobial 4-Bromopyrrole Alkaloid Containing L-Idonic Acid Core from the Northwestern Pacific Marine Sponge Lissodendoryx papillosa
Authors: Tabakmakher Kseniya M. , Makarieva Tatyana N. , Sabutski Yuri E. , Kokoulin Maxim S. , Menshov Alexander S. , Popov Roman S. , Guzii Alla G. , Shubina Larisa K. , Chingizova Ekaterina A. , Chingizov Artur R. , Yurchenko Ekaterina A. , Fedorov Sergey N. , Grebnev Boris B. , von Amsberg Gunhild , Dyshlovoy Sergey A. , Ivanchina Natalia V. , Dmitrenok Pavel S.
Published: August 2024

Stonikacidin A (1), the first representative of a new class of 4-bromopyrrole alkaloids containing an aldonic acid core, was isolated from the marine sponge Lissodendoryx papillosa. The compound is named in honor of Prof. Valentin A. Stonik, who is one of the outstanding investigators in the field of marine natural chemistry. The structure of 1 was determined using NMR, MS analysis, and chemical correlations. The L-idonic acid core was established by the comparison of GC, NMR, MS, and optical rotation data of methyl-pentaacetyl-aldonates obtained from the hydrolysis products of 1 and standard hexoses. The L-form of the idonic acid residue in 1 was confirmed by GC analysis of pentaacetate of (S)-2-butyl ester of the hydrolysis product from 1 and compared with corresponding derivatives of L- and D-idonic acids. The biosynthetic pathway for stonikacidin A (1) was proposed. The alkaloid 1 inhibited the growth of Staphylococcus aureus and Escherichia coli test strains, as well as affected the formation of S. aureus and E. coli biofilms. Compound 1 inhibited the activity of sortase A. Molecular docking data showed that stonikacidin A (1) can bind with sortase A due to the interactions between its bromine atoms and some amino acid residues of the enzyme.
The Neuroprotective Role of Indole-3-Propionic Acid in Migraine Pathophysiology
Authors: Agircan Dilek , Taskin Seyhan , Cekic Murat , Celik Hakim
Published: August 2024

Background and Objectives: Migraine is a leading cause of disability worldwide, with complex pathophysiological mechanisms involving oxidative and nitrosative stress. Recent research suggests that Indole-3-Propionic Acid (IPA) may have a neuroprotective role in reducing nitrosative stress. This study aims to elucidate the roles of IPA and nitrosative stress biomarkers in migraine patients, focusing on their potential as therapeutic targets. Materials and Methods: This cross-sectional, case-control study included 57 migraine patients and 30 healthy controls. Patients were categorized into episodic migraine (EM) and chronic migraine (CM) groups. Socio-demographic and clinical characteristics were documented through structured interviews. Validated scales such as the Visual Analog Score (VAS), Headache Impact Test 6 (HIT-6), Migraine Disability Assessment Test (MIDAS), Migraine 24 h Quality of Life Scale (24 h QoL), Mini-Mental State Examination (MMSE), and Migraine Attacks–Subjective Cognitive Impairments Scale (Mig-SCog) were administered. Venous blood samples were collected, and serum levels of IPA, Nitric Oxide (NO), Nitric Oxide Synthase (NOS), and Peroxynitrite (ONOO−) were measured using ELISA and spectrophotometric methods. Results: Significant differences in serum IPA and NO levels were observed between migraine patients and controls. Specifically, higher serum IPA levels were found in the EM group, while higher serum NO levels were observed in the CM group. Elevated NO levels correlated with increased migraine attack frequency. Conversely, serum IPA levels showed a negative correlation with attack frequency, suggesting a protective role. Specifically, NO levels were positively correlated with the number of painful days, NSAID usage, VAS scores, HIT-6 scores, and MIDAS scores, while negatively correlated with 24 h QoL scores. Conclusions: The study highlights the significant involvement of IPA and nitrosative stress in migraine pathophysiology. Elevated IPA levels, particularly in EM patients, suggest its potential neuroprotective role. These findings underscore the importance of targeting oxidative and nitrosative stress pathways in developing effective migraine therapies.
The Respiratory Rate, Age, and Mean Arterial Pressure (RAM) Index: A Novel Prognostic Tool to Predict Mortality among Adult Patients with Acute Heart Failure in the Emergency Department
Authors: Chang Yu , Peng Chan-Huan , Chen Jiann-Hwa , Lee Yu-Ting , Wu Meng-Yu , Chung Jui-Yuan
Published: August 2024

Background and Objectives: Acute heart failure (AHF) is a life-threatening condition frequently encountered in the emergency department (ED). Identifying reliable prognostic indicators for in-hospital mortality is crucial for risk stratification and the appropriate management of AHF patients. This study aimed to assess the most effective method for predicting in-hospital mortality among various physiological parameters in patients with AHF presenting to the ED. Additionally, the study evaluated the effectiveness of the RAM index—respiratory rate (RR), age, and mean arterial pressure (MAP)—derived from the shock index (SI) by replacing heart rate with RR, as a novel prognostic tool. This was compared with the SI and its other derivatives to predict in-hospital mortality in adult patients with AHF presenting to the ED. Materials and Methods: This is a retrospective study conducted in the ED of an urban medical center, enrolling adult patients with signs and symptoms of AHF, who met the epidemiological diagnosis criteria, between January 2017 and December 2021. Baseline physiological parameters, including the RR, heart rate, systolic blood pressure, and diastolic blood pressure, were recorded upon ED admission. The RAM index was calculated as the RR multiplied by the age divided by the MAP. Statistical analysis was performed, including univariate analysis, logistic regression, and receiver operating characteristic (ROC) curve analysis. Results: A total of 2333 patients were included in the study. A RAM index > 18.6 (area under ROC curve (AUROC): 0.81; 95% confidence interval (CI): 0.79–0.83) had a superior mortality discrimination ability compared to an SI > 0.77 (AUROC: 0.75; 95% CI: 0.72–0.77), modified shock index > 1.11 (AUROC: 0.75; 95% CI: 0.73–0.77), age shock index > 62.7 (AUROC: 0.74; 95% CI: 0.72–0.76), and age-modified shock index > 79.9 (AUROC: 0.75; 95% CI: 0.73–0.77). A RAM index > 18.6 demonstrated a 7.36-fold higher risk of in-hospital mortality with a sensitivity of 0.80, specificity of 0.68, and negative predictive value of 0.97. Conclusions: The RAM index is an effective tool to predict mortality in AHF patients presenting to the ED. Its superior performance compared to traditional SI-based parameters suggests that the RAM index can aid in risk stratification and the early identification of high-risk patients, facilitating timely and aggressive treatment strategies.
Behaviour of Dissimilar Welded Connections of Mild Carbon (S235), Stainless (1.4404), and High-Strength (S690) Steels under Monotonic and Cyclic Loading
Authors: Ene Anna , Stratan Aurel , Both Ioan
Published: August 2024

In the context of an increasing interest in the use of high-performance steels in the construction industry due to their superior mechanical properties, understanding the behaviour and assessing the performance of dissimilar welded connections becomes essential. When several steel grades are adopted for fabrication of the same dissipative element, dissimilar welded connections have a decisive importance regarding the seismic performance of the structural member. This paper presents the experimental results of monotonic and low-cycle fatigue (LCF) tests on dissimilar welded connections. The welded connections are designed to reproduce the loading state that occurs between the web and the flanges of dissipative links in an eccentrically braced frame, and represent combinations of S235 mild carbon steel, 1.4404 austenitic stainless steel, and S690 high-strength steel. The obtained experimental results provide a better understanding of the behaviour of dissimilar welded connections through the evaluation of their strength, ductility, and failure mechanisms, providing a basis for finite element (FE) models’ calibration for further numerical simulations. This study contributes to the evaluation of the feasibility of connections between dissimilar steels in seismic-resistant steel structures.
Research on Adaptive Closed-Loop Control of Microelectromechanical System Gyroscopes under Temperature Disturbance
Authors: Yang Ke , Li Jianhua , Yang Jiajie , Xu Lixin
Published: August 2024

Microelectromechanical System (MEMS) gyroscopes are inertial sensors used to measure angular velocity. Due to their small size and low power consumption, MEMS devices are widely employed in consumer electronics and the automotive industry. MEMS gyroscopes typically use closed-loop control systems, which often use PID controllers with fixed parameters. These classical PID controllers require a trade-off between overshoot and rise time. However, temperature variations can cause changes in the gyroscope’s parameters, which in turn affect the PID controller’s performance. To address this issue, this paper proposes an adaptive PID controller that adjusts its parameters in response to temperature-induced changes in the gyroscope’s characteristics, based on the error value. A closed-loop control system using the adaptive PID was developed in Simulink and compared with a classical PID controller. The results demonstrate that the adaptive PID controller effectively tracked the changes in the gyroscope’s parameters, reducing overshoot by 96% while maintaining a similar rise time. During gyroscope startup, the adaptive PID controller achieves faster stabilization with a 0.036 s settling time, outperforming the 0.06 s of the conventional PID controller.
Towards a Comprehensive Definition of Pandemics and Strategies for Prevention: A Historical Review and Future Perspectives
Authors: Dias Ricardo Augusto
Published: August 2024

The lack of a universally accepted definition of a pandemic hinders a comprehensive understanding of and effective response to these global health crises. Current definitions often lack quantitative criteria, rendering them vague and limiting their utility. Here, we propose a refined definition that considers the likelihood of susceptible individuals contracting an infectious disease that culminates in widespread global transmission, increased morbidity and mortality, and profound societal, economic, and political consequences. Applying this definition retrospectively, we identify 22 pandemics that occurred between 165 and 2024 AD and were caused by a variety of diseases, including smallpox (Antonine and American), plague (Justinian, Black Death, and Third Plague), cholera (seven pandemics), influenza (two Russian, Spanish, Asian, Hong Kong, and swine), AIDS, and coronaviruses (SARS, MERS, and COVID-19). This work presents a comprehensive analysis of past pandemics caused by both emerging and re-emerging pathogens, along with their epidemiological characteristics, societal impact, and evolution of public health responses. We also highlight the need for proactive measures to reduce the risk of future pandemics. These strategies include prioritizing surveillance of emerging zoonotic pathogens, conserving biodiversity to counter wildlife trafficking, and minimizing the potential for zoonotic spillover events. In addition, interventions such as promoting alternative protein sources, enforcing the closure of live animal markets in biodiversity-rich regions, and fostering global collaboration among diverse stakeholders are critical to preventing future pandemics. Crucially, improving wildlife surveillance systems will require the concerted efforts of local, national and international entities, including laboratories, field researchers, wildlife conservationists, government agencies and other stakeholders. By fostering collaborative networks and establishing robust biorepositories, we can strengthen our collective capacity to detect, monitor, and mitigate the emergence and transmission of zoonotic pathogens.
Revisiting the Concealed Zn-Pb±(Ag,Ge) VMS-Style Ore Deposit, Molai, Southeastern Peloponnese, Greece
Authors: Kevrekidis Elias , Triantafyllidis Stavros Savvas , Tombros Stylianos Fotios , Kokkalas Sotirios , Papavasiliou Joan , Kappis Konstantinos , Papageorgiou Konstantinos , Koukouvelas Ioannis , Fitros Michalis , Zouzias Dimitrios , Voudouris Panagiotis , Zhai Degao , Seymour Karen St
Published: August 2024

The concealed Molai Zn-Pb±(Ag,Ge) stratiform deposit in southeastern Peloponnese is hosted in Triassic intermediate tuffs, ignimbrites and subaerial andesitic flows. The host rocks display trace element signatures of a Supra-Subduction Zone (SSZ) setting. Three ore-forming stages are recognized, with stages I and II related to formation of the epigenetic, stratiform, massive-to-semi-massive ore and a late stage III associated with vein-type mineralization. The O and D isotope geochemistry of gangue chlorite and epidote reveal mixing with fresh meteoric water during the weaning stages of the hydrothermal activity of the late stage II due to uplifting of the hydrothermal system. Sphalerite is the major ore phase, with three different varieties formed during stages I (Sp-I) and II (Sp-II and Sp-III). All sphalerite varieties coexist, depicting gradual change in the chemistry of the ore-forming fluids. Molai ores are characterized by elevated Ag and Ge contents. Tetrahedrite is the major Ag carrier, while among the three sphalerite varieties, early Sp-I comprises the highest Ge contents. The Molai Zn-Pb±(Ag,Ge) deposit is characterized by intermediate features between bimodal felsic massive sulfides and subaerial epithermal systems based on the shallow formation depth, the presence of hydraulic breccias associated with phase separation, the ore formation along high-angle faults, the relatively low ore-forming temperatures below 250 °C obtained from geothermometry, and the absence of the typical structure of bimodal felsic type ores.
Assessing Mining Performance Indicators in Relation to the SDGs: Development of a Guided Methodology and Its Application in an Iron Ore Mine
Authors: Silva Rhaymá do Carmo , Ayres da Silva Anna Luiza Marques
Published: August 2024

The concept of sustainability has gained significant recognition across all industrial sectors, particularly in response to the potential global environmental crisis. In mining, sustainability ensures responsible operations by addressing environmental, social, and economic aspects. Performance indicators, categorized into environmental, social, economic, and governance groups, are monitored to oversee these aspects. In 2015, the UN established 17 Sustainable Development Goals (SDGs) as a global agenda for achieving equitable economic and social development. This study presents a methodology to evaluate performance indicators in an iron ore mine in southeast Pará, Brazil, to understand whether and how these indicators guide the mine’s operations toward fulfilling the SDGs. This study was based on the application of a methodology specifically developed for this purpose, where a seven-step application was defined, with each step involving an activity to be carried out to verify the correlation performance indicators with the SDGs. By applying the proposed methodology, the assessment of 286 performance indicators was conducted, revealing that 55.24% aligned the mine’s operation with the SDGs. Furthermore, the developed methodology may be applied to other mining enterprises, supporting their sustainability reports and compliance with the sector’s regulatory standards and mine closure plan requirements.
A Mathematical Model for Enhancing CO2 Capture in Construction Sector Using Hydrated Lime
Authors: Vidal de la Peña Natalia , Marquis Séverine , Jacques Stéphane , Aubry Elise , Léonard Grégoire , Toye Dominique
Published: August 2024

The construction sector is among the most polluting industries globally, accounting for approximately 37.5% of the European Union’s total waste generation in 2020. Therefore, it is imperative to develop strategies to enhance the sustainability of this sector. This paper proposes a multiscale COMSOL Multiphysics numerical model for an ex situ mineral carbonation process of hydrated lime. The carbonation process is characterized at both the micro- and macroscale levels, encompassing interactions within and between the particles. This model incorporates both reaction and diffusion phenomena, considering the effects of porosity and liquid-water saturation parameters. Generally, liquid-water saturation enhances the reaction kinetics but not CO2 diffusion, while porosity improves CO2 diffusion throughout the granular bed. The model has been experimentally validated, showing promising results by accurately characterizing carbonation tendencies and the influence of the CO2 flow rate and the initial water-to-solid ratio on the carbonation process. The proposed mathematical model facilitates the study of various parameters, including particle radius, reactor geometry, and material porosity. This analysis is valuable for both current and future projects, as it aims to identify the most profitable configurations for the hydrated lime carbonation process.
Conservation Assessment of the Stone Blocks in the Northeast Corner of the Karnak Temples in Luxor, Egypt
Authors: Fahmy Abdelrhman , Molina-Piernas Eduardo , Domínguez-Bella Salvador
Published: August 2024

The Karnak Temples complex, a monumental site dating back to approximately 1970 BC, faces significant preservation challenges due to a confluence of mechanical, environmental, and anthropogenic factors impacting its stone blocks. This study provides a comprehensive evaluation of the deterioration affecting the northeast corner of the complex, revealing that the primary forms of damage include split cracking and fracturing. Seismic activities have induced out-of-plane displacements, fractures, and chipping, while flooding has worsened structural instability through uplift and prolonged water exposure. Soil liquefaction and fluctuating groundwater levels have exacerbated the misalignment and embedding of stone blocks. Thermal stress and wind erosion have caused microstructural decay and surface degradation and contaminated water sources have led to salt weathering and chemical alterations. Multi-temporal satellite imagery has revealed the influence of vegetation, particularly invasive plant species, on physical and biochemical damage to the stone. This study utilized in situ assessments to document damage patterns and employed satellite imagery to assess environmental impacts, providing a multi-proxy approach to understanding the current state of the stone blocks. This analysis highlights the urgent need for a multi-faceted conservation strategy. Recommendations include constructing elevated platforms from durable materials to reduce soil and water contact, implementing non-invasive cleaning and consolidation techniques, and developing effective water management and contamination prevention measures. Restoration should focus on repairing severely affected blocks with historically accurate materials and establishing an open museum setting will enhance public engagement. Long-term preservation will benefit from regular monitoring using 3D scanning and a preventive conservation schedule. Future research should explore non-destructive testing and interdisciplinary collaboration to refine conservation strategies and ensure the sustained protection of this invaluable historical heritage.
New Advance in the Study of Shale Oil Generation Peak Determination and Diagenetic Pore Evolution
Authors: Su Haikun , Guo Shaobin
Published: August 2024

Shale formations globally are widely distributed with abundant resources and varied thermal maturation ranges. However, the understanding of shale’s oil generation peak, diagenetic stages, and pore evolution remains incomplete. This study investigates shale samples of varying maturities and organic matter content from representative oil and gas basins in China and the United States. Comprehensive characterization was conducted using thermal simulation, rock X-ray diffraction analysis, N2 and CO2 adsorption, and mercury injection analysis. The study delineates the hydrocarbon generation process in shale, identifies the oil generation threshold, determines the peak oil generation, and categorizes shale’s diagenetic stages based on clay minerals and pore evolution. The results indicate: (1) highly mature shale exhibits delayed hydrocarbon expulsion and peak oil generation, starting at Ro values greater than 0.75% and reaching peak oil generation at Ro levels surpassing 1.2%. In contrast, peak oil generation in less mature shale initiates at Ro values of 1.1%, providing a more precise depiction of the shale’s diagenetic evolution stages; (2) the higher the TOC content of shale, the greater its hydrocarbon generation capacity, showing a robust positive correlation between hydrocarbon generation and TOC; (3) the diagenesis and pore evolution of shale can be categorized into four distinct stages: the early diagenesis stage (Ro < 0.5%), dominated by mesopores, and with reduced pore volume and surface area; the middle diagenesis stage A (0.5%–1.1%), where shale pore volume has been enhanced while the surface area has been reduced; the middle diagenesis stage B (1.1%–2.0%), where an initial decrease followed by an increase in mesopore volume occurs, along with a modest increase in macropores; and the late diagenesis stage (Ro > 2.0%), with increased organic pores and microfractures, while both pore volume and surface area expand. The study suggests that a Ro of 1.1% marks the peak oil generation period for shale, occurring during the early stage of middle diagenesis, characterized by larger pore volume and surface area, crucial for shale oil and gas enrichment.
Investigating the Antimicrobial Properties of Essential Oil Constituents and Their Mode of Action
Authors: Noui Mehidi Ilham , Ait Ouazzou Abdenour , Tachoua Wafa , Hosni Karim
Published: August 2024

Essential oils (EOs) and plant extracts, rich in beneficial chemical compounds, have diverse applications in medicine, food, cosmetics, and agriculture. This study investigates the antibacterial activity of nine essential oil constituents (EOCs) against Escherichia coli, focusing on the effects of treatment pH and biosynthetic requirements. The impact of EOCs on bacterial inactivation in E. coli strains was examined using both nonselective and selective culture media. Computer-assisted drug design (CADD) methods were employed to identify critical binding sites and predict the main binding modes of ligands to proteins. The EOCs, including citral, α-terpinyl acetate, α-terpineol, and linalool, demonstrated significant bacterial inactivation, particularly under acidic conditions. This study revealed that EOCs have an effect on the presence of sublethal damage to both the cytoplasmic membrane and the outer membrane in Gram-negative bacteria. Adding penicillin G to the repair medium prevents the recovery of sublethal injuries in E. coli treated with α-terpinyl acetate, α-terpineol, linalool, and citral, indicating that peptidoglycan synthesis is essential for recovering from these injuries. However, penicillin G did not hinder the recovery process of most sublethally injured cells treated with the other assessed EOCs. Molecular docking studies revealed the favorable binding interactions of α-terpinyl acetate, α-terpineol, linalool, and citral with the β-lactamase enzyme Toho-1, indicating their potential as effective antibacterial agents. The findings suggest that EOCs could serve as viable alternatives to synthetic preservatives, offering new strategies for combating antibiotic-resistant bacteria.