bluuebunny/crossref_metadata_2025 huggingface dataset:
Structural basis of Zika virus NS1 multimerization and human antibody recognition
Authors: Luo Dahai , Chew Bing Liang Alvin , Ngoh An Qi , Phoo Wint Wint , Weng Mei Jie Grace , Chan Kitti Wing Ki , Tan Yong Jun , Gelbart Terri , Xu Chenrui , Wu Bin , Tan Gene , Vasudevan Subhash , Ho Jun Sheng
Published: October 2023

The Zika virus (ZIKV) is a mosquito-transmitted flavivirus related to the dengue virus that has emerged in recent global outbreaks, with previously unreported neurological or birth abnormalities. There remains a large, unmet need for efficacious vaccines and antiviral agents against ZIKV. Flavivirus non-structural protein 1 (NS1) is the only secreted viral protein that has proven useful in diagnostics. However, its physiologically relevant structural forms and pathogenesis mechanisms remain unclear. While many antibodies targeting NS1 with mapped immunodomain epitopes have been reported, antibody-NS1 structures are starting to emerge, which may guide vaccine and therapeutic design. Here, we present high-resolution cryoEM structures of ZIKV recombinant secreted NS1 (rsNS1) and its complexes with three human monoclonal antibodies, as well as evidence of ZIKV infection-derived secreted NS1 (isNS1) binding to HDL. We showed that ZIKV rsNS1 forms tetramers and filamentous repeats of tetramers. The studied antibodies (AA12, EB9, GB5) did not disrupt the ZIKV NS1 tetramers as they bound to the wing and connector subdomain to the β-ladder. Our study reveals new insights into NS1 multimerization, highlights the need to distinguish the polymorphic nature of rsNS1 and isNS1, and expands the mechanistic basis of the protection conferred by antibodies targeting NS1.
An Idiopathic Intracranial Hypertension with bulbar paralysis as the first symptom
Authors: Wang Chen , Zhan Yihong , Xiao Naian , Yu Zhenzhen
Published: October 2023

Idiopathic intracranial hypertension (IIH) is a neurological disorder characterized by markedly increased intracranial pressure getting rid of strokes, tumors or other diseases. Our case describes a middle-aged lady who gained progressive drinking cough, slurred speech and depression that was observed with the magnetic resonance (MR) images of empty sella, buckling and dilatation of the optic nerve sheaths, sigmoid sinus stenosis and brain hernia embedded sigmoid sinus ditch. After decreasing intracranial pressure and improving circulation treatment, the symptoms of the patient improved within half a month. Our case highlights that, an idiopathic intracranial hypertension patient with brain hernia embedded sigmoid sinus ditch besides all the classic magnetic resonance imaging (MRI) appearance, who develop bulbar paralysis as the first symptom instead of classic symptoms such as headache, nausea and vomiting, drastically decreasing intracranial pressure is considered to be effective.
Physics-informed W-Net GAN for the direct stochastic inversion of fullstack seismic data into facies models
Authors: Miele Roberto , Azevedo Leonardo
Published: October 2023

Predicting the spatial distribution of geological facies in the subsurface from fullstack geophysical data is a main step in the geo-modeling workflow for energy exploration and environmental tasks and requires solving an inverse problem. Generative adversarial networks (GAN) have shown great potential for geologically accurate inverse modeling, although with limitations in computational costs and in accounting for uncertainty in the prediction of facies-dependent properties. To overcome this limitation, we propose a GAN architecture for multivariate inverse modeling, which is able to learn the physics-based mapping between facies and seismic domains, and account for the spatial uncertainties of the facies and elastic properties. In a single training stage, the network models a distribution of realistic facies patterns solving a seismic inversion problem, based on the observed data, and learned features. The method is first demonstrated on 2-D application examples, and then applied for the inversion of a 2-D seismic section extracted from the Norne field (Norwegian North Sea). The results show that through fast training, the proposed GAN can model facies distributions fitting the observed data, reproducing the prior facies patterns and the data uncertainty, while honoring the physics of the system under investigation.
Atypical Carcinoid of the Lung with Brown Tumor of the Femur – A Case Report of a Rare Association
Authors: Zenezan Dina , Tushir Abhimanyu , Yin Jiejing , Arriola Aileen G , Proca Daniela
Published: October 2023

Background: A diagnosis of neuroendocrine tumor (NET) is challenging, but critical, bearing serious implications concerning treatment and prognosis.
Case Report: We describe a 39-year-old female presented with 2 weeks of increasing right leg pain preventing her from ambulating. She had a 6 month-long history of nausea, vomiting, and weight loss. Lab investigations showed hypercalcemia (13.1 mg/dl) and extremely elevated PTH (>2000 pg/ml). Differential diagnosis included primary hyperparathyroidism, as well as secondary hyperparathyroidism due to ectopic PTH production. Additional Imaging studies revealed a large lytic lesion in the femoral metaphysis and a well-circumscribed homogenous nodule in the right lower lobe. A lung biopsy showed a well-differentiated neuroendocrine neoplasm. Subsequently, right lower lobectomy was performed. The histologic and immuohistochemical features were consistent with a well differentiated neuroendocrine tumor, grade 2/3 (4.0 cm greatest dimension) with focal necrosis, and focally positive with Chromogranin, Synaptophysin and CD56, diffusely and strongly positive with AE1/AE3 and PTH, and negative with P-40, CDX2 and TTF1. A ki-67 showed approximately 15% nuclear positivity. Presence of necrosis, CDX2 negativity, and no involvement of other organs confirmed it as a primary lung neuroendocrine tumor with ectopic PTH secretion and secondary hyperparathyroidism.
Conclusion: This a very rare occurrence that raises awareness to the possible different etiologies of secondary hyperparathyroidism. Well-differentiated NETs are rare overall, while the hormone secreting NETs are very unusual.
Influence of preceding crops and sowing date on the yield of varieties of Triticum aestivum L. under the conditions of the central Forest-Steppe of Ukraine
Authors: Kyrylenko V. V. , Humeniuk O. V. , Suddenko Y. M. , Zaima O. A. , Los R. M. , Khomenko Т. М.
Published: October 2023

Purpose. To determine the yield potential of new winter wheat varieties of the Myronivka breeding as a function of preceding crops and sowing dates, and to determine their proportion of influence in the conditions of the central ForestSteppe of Ukraine.
Methods. The research was conducted in a four-factor field experiment at the V. M. Remeslo Myronivka Institute of Wheat, National Academy of Agrarian Sciences of Ukraine during 2018/19–2020/21.
Results. As a result of the study of five promising varieties of winter wheat, sown on September 25 and October 5 after two predecessors (soybean and sunflower), it was found that, regardless of the sowing dates, the average yield of the varieties studied was higher after the predecessor soybean and varied from 3.77 to 6.24 t/ha compared to its predecessor sunflower – 3.35–5.52 t/ha. The variety ‘MIP Yuvileina’ produced the maximum yield in the first sowing period (5.52 and 6.24 t/ha after the preceding sunflower and soybean, respectively) and the variety ‘MIP Fortuna’ – in the second sowing period (5.46 t/ha after the preceding soybean).
Conclusions. The yield potential of winter wheat varieties was determined in relation to their predecessors and sowing dates in the conditions of the central Forest-Steppe of Ukraine. According to the results of the variance analysis of the obtained data, the proportion of influence of these factors on the crop yield was determined. The largest contribution to the yield variance was made by the year of sowing (67.8%) and the predecessor (20.9%).
Productivity and grain quality of winter triticale varieties (Triticosecale Wittmack el. Camus) under different soil and climatic growing conditions
Authors: Kyrylchuk A. M. , Liashenko S. O. , Bezprozvana I. V. , Chukhleb C. L. , Shcheina N. P. , Shkliar V. D.
Published: October 2023

Purpose. To evaluate the productivity and grain quality of winter triticale varieties grown under different soil and climatic conditions.
Methods. The research process involved laboratory, computational and statistical methods, and analysis and synthesis to draw conclusions.
Results. HTC (IV–X) was found to vary significantly monthly, annually and in general between the research sites. It was found that the yield of winter triticale varieties in the Forest-Steppe and Polissia zones was 5.3 t/ha. The maximum yield in the Forest-Steppe zone was achieved by the variety ‘MIP Feniks’ (5.9 t/ha), in the Polissia zone by the variety ‘Pamiati Patseky’ (5.8 t/ha). It was found that the protein content of winter triticale varieties for the 2019–2020 research years in the Forest-Steppe zone was on average 12.6% and ranged from 12.2% (‘Liubomyr’) to 13.3% (‘MIP Yatahan’), which according to the classifier corresponded to grain of medium quality and can be used in the confectionery industry. The coefficient of variation (V,%) for this characteristic was 3.5%. In the Polissia zone, the protein content of the varieties averaged 13.6% over the years of research and ranged from 12.9% – medium content (‘MIP Feniks’) to 14.3% – high content (‘MIP Yatahan’). The intrazone variation was low and amounted to 4.0%. Correlation and regression analysis showed that an increase in the active temperature during the vegetation period up to 3203 оС allows an increase in the productivity indicators and in the weight of 1000 grains from 5.6 to 6.1 t/ha and from 46.8 to 53.5 g, respectively; an increase in precipitation during the vegetation period up to 515.1 mm leads to a decrease in the weight of 1000 grains from 45.2 to 38.1 g; with an increase in the amount of active temperatures and precipitation during the vegetation period from 3167.65 to 3202.9 оС and from 413.85 to 515.1 mm, respectively, it is possible to increase the protein content in grain from 12.4 to 13.8%; with an increase in the yield and weight of 1000 grains from 5.8 to 6.1 t/ha and from 51.8 to 53.8 g, the protein content of the grain can be reduced from 13.1 to 12.0%.
Conclusions. Different responses of varieties to zonal growing conditions were observed. A positive influence of the rainfall factor during the growing season on the yield of winter triticale in Forest-Steppe and Polissia (r = 0.66 and 0.34 units) and on the increase of the protein content of grain grown in the Polissia zone (r = 0.56) was revealed.
The impact of organizational change on employee turnover intentions at private hospitals: The moderating role of emotional intelligence
Authors: Khraim Hamza
Published: October 2023

The objective of this study is to examine whether employees’ reactions to organizational change can affect employees’ turnover intentions at private hospitals in Jordan, as well as a moderating impact of emotional intelligence on this relationship. The analysis is quantitative, using a questionnaire that was distributed online among private hospital employees. A total of 408 respondents completed the questionnaires and were included in the analysis. The results of the first hypothesis testing show that β = 0.960, t = 0.69.4, p < 0.00 and prove that organizational change significantly influences employee turnover intentions. Concerning organizational change dimensions, the results of cognitive reaction were β = 0.656, t = 0.17.5, p < 0.00, for emotional reaction, β = 0.680, t = 0.31.1, p < 0.00, while for behavioral reaction, β = 0.718, t = 0.22.7, p < 0.00. Finally, moderation results show that emotional intelligence has a significant effect, thus moderating the relationship between organizational change and turnover intentions (β = 0.828, t = 0.11.3, p < 0.00).
AGE DYNAMICS OF CANCER INCIDENCE INTENSITY INDICATES EXISTENCE OF SOME FRAILTY SUBGROUPS
Authors:   Southern Urals Biophysics Institute, 19 Ozerskoe highway, Ozersk, 456780, Russian Federation, Obesnyuk V.F.
Published: October 2023

The problem of managing population and occupational risks of cancer incidence or mortality presupposes knowledge on biological mechanisms of their formation. These mechanisms determine dynamics of mass processes recorded by statistics. However, there is still no clear understanding of the causal relationship between possible factors of cancer incidence and its real dynamics. The article analyzes a hypothesis about significant influence on dynamics of incidence rates between ‘health’ and ‘disease’ states exerted by an intermediate transitional and objectively existing ‘frailty’ state, which is characterized by accelerated withdrawal from observation compared with the intensity associated with the general variability of individual properties of a population. It has been statistically established that the dynamics of such common diseases as stomach cancer, lung cancer, breast cancer, prostate cancer, and thyroid cancer can be explained by the fact that almost all diagnosed cases are observed after an individual enters a vulnerable group long before the diagnosis itself. From this point of view, two fundamentally different biological mechanisms of occurrence of neoplasms should be distinguished: induction as a transition from the state of ‘health’ to the state of ‘frailty’, as well as promotion as a transition from ‘frailty’ to ‘disease’. Each of these transformations should be characterized in a population by their intensity and their dependence on endogenous or exogenous risk factors. It is shown that some known facts of paradoxical changes in radiosensitivity indicators can be satisfactorily interpreted within the concept of a frailty subgroup by using numerical modeling on the example of modifying the dynamics of thyroid cancer incidence under influence of ionizing radiation. The facts were established in 1994–2006 and have not yet received a proper explanation since the concept discussed by the authors of the studies has not been involved.
ASSESSING RISKS OF HEPATOBILIARY DISORDERS IN CHILDREN UNDER COMBINED EXPOSURE TO PERSISTING HERPES AND TECHNOGENIC CHEMI-CALS
Authors:   Federal Scientific Center for Medical and Preventive Health Risk Management Technologies,  82 Monastyrskaya St., Perm, 614045, Russian Federation, Maklakova О.А. ,   Perm State University, 15 Bukireva St., Perm, 614068, Russian Federation, Valina S.L. ,   Federal Scientific Center for Medical and Preventive Health Risk Management Technologies,  82 Monastyrskaya St., Perm, 614045, Russian Federation, Shtina I.Е. ,   Federal Scientific Center for Medical and Preventive Health Risk Management Technologies,  82 Monastyrskaya St., Perm, 614045, Russian Federation, Ustinova О.Yu. ,   Federal Scientific Center for Medical and Preventive Health Risk Management Technologies,  82 Monastyrskaya St., Perm, 614045, Russian Federation
Published: October 2023

Chronic persistent viral infection leads to developing immune deficiency and may induce lesions in many organs, the hepatobiliary system included. This, in its turn, may facilitate the onset of diseases of the digestive system under exposure to technogenic chemicals, especially those able to produce hepatotoxic effects. In this study, our aim was to examine risks of developing hepatobiliary disorders in children under combined exposure to persisting herpes infection and technogenic chemicals. We conducted a clinical examination of 324 children aged between 6 and 17 years living either in a large industrial city or on a territory where the sanitary-hygienic situation was favorable. The examination included a clinical checkup, laboratory diagnostic tests identifying herpes markers, chemical analyses aimed at establishing levels of technogenic chemicals in blood, and ultrasound scanning of hepatobiliary organs. We established that exposure to airborne technogenic chemicals created elevated levels of aromatic hydrocarbons and formaldehyde in 64.9–97.6 % of the exposed children; elevated manganese and chromium levels, in 20.8–34.6 % of them. Markers of cytomegalovirus (CMV) and Epstein Barr virus (EBV) were detected in 75 % of the exposed children; each second child had HSV-1 or HSV-2; each third child had human herpesvirus 6. Hepatobiliary disorders occurring under combined exposure to persistent herpes and technogenic chemicals were represented by structural liver changes in 30.8 % of the examined children; abnormally shaped gallbladder or reactive changes in its walls and dyscholia, in 15.7–48.8 %. These disorders entail elevated levels of direct bilirubin and greater ALT against imbalance of oxidant and antioxidant systems and manifest themselves as biliary pathology in 69.5 % of cases. Exposed children with persistent herpes infection have 1.2–2.3 times higher likelihood of developing structural changes in the liver and gallbladder pathology and up to 4.3 times higher risks of biliary dysfunction and chronic gastroduodenitis.
RISK OF PERINATAL MORTALITY AMONG THE OFFSPRING OF WORKERS EMPLOYED AT PRODUCTION WITH RADIATION HAZARDS
Authors:   Southern Urals Biophysics Institute, 19 Ozyorskoe highway, Ozyorsk, 456783, Russian Federation, Sosnina S.F. , Okatenko P.V. ,   Southern Urals Biophysics Institute, 19 Ozyorskoe highway, Ozyorsk, 456783, Russian Federation, Sokolnikov M.E. ,   Southern Urals Biophysics Institute, 19 Ozyorskoe highway, Ozyorsk, 456783, Russian Federation
Published: October 2023

A retrospective analysis was performed among 25,007 children born in 1949–1973; parents of 14,580 of these children were exposed to long-term occupational radiation at Mayak PA. The study provides frequency and dynamics of perinatal mortality and comparative analysis of perinatal mortality by sex, year of birth, parental age at childbirth, and dose categories of radiation exposure. Research data were analyzed by methods of non-parametric statistics. We calculated a relative risk (RR) of perinatal mortality among the offspring of exposed and unexposed parents with 95 % CI. The rate of perinatal mortality was generally the same in both groups, 19.9 for 103 in the test group and 17.9 for 103 in the control, p > 0.05. Stillbirths among male offspring were statistically significantly more often observed in the test group due to contribution of the children with only mothers exposed to occupational radiation exposure at Mayak PA prior to conception and offspring exposed in utero. Intrauterine fetal death was observed statistically significantly more often among boys of the test group compared to controls: 2.9 against 0.9 for 103. Rates of stillbirths and perinatal mortality in the main group statistically significantly exceeded the values in the comparison group in 1949–1953: RR = 2.69 (CI: 1.46–4.95) and 2.12 (1.38–3.28) respectively. Significant statistical differences in the perinatal mortality risk were established in certain categories of preconception and intrauterine gamma-exposure. The identified peculiarities of unfavorable outcomes in the perinatal period that were detected among the offspring of Mayak PA workers could be eligible for further epidemiological monitoring. Poly-etiology character of perinatal mortality requires further follow up of the cohort of the offspring born to atomic production workers.
ON POSSIBLE PRACTICAL APPLICATIONS OF THE GUT MICROBIOME RESEARCH IN THE PREVENTION, DIAGNOSIS, ASSESSMENT OF, AND TREATMENT MODIFICATION FOR MULTIPLE SCLEROSIS IN PATIENTS FROM RISK GROUPS
Authors:   Rencontres Internationales Santé Environnement – RISE, Strasbourg, France, Zjukovskaja C.K.
Published: October 2023

Research into the gut microbiota (GM) in multiple sclerosis (MS) has the potential to lead to a number of practical applications in the prevention, diagnosis, assessment of, and treatment modification for, MS. Four most promising areas include biomarkers, treatment personalization, drug development as well as disease prevention and mitigation. Changes in the GM have been observed in individuals with MS; analysis of the GM composition may help to identify individuals at risk of developing the disease or to monitor disease progression. Dietary interventions aimed at improving gut health could be used as a complementary approach to traditional MS treatments in order to reduce inflammation thereby potentially improving MS symptoms and lessening disease progression. Differences in the GM between individuals with MS suggest that personalized treatment approaches based on an individual's microbiome composition could be effective. Manip-ulating the GM could therefore be a potential avenue for drug development in MS. In addition, the exploration of bacteria or bacterial metabolites as therapeutic agents to modulate the immune system and reduce inflammation is also promising. Such explorations may even help identify strategies for preventing the development of MS in at-risk individuals. Overall, practical applications of gut microbiome research in MS are still in the early stages and further research is needed to fully understand the mechanisms underlying the relationship between the gut microbiome and MS and to determine the most effective interventions for improving gut health in individuals with the disease.
Saberes e olhares sobre o turismo de base comunitária
Authors: Sudré Stephanni Gabriella Silva , Figueiredo Silvio Lima
Published: October 2023

Diante do desafio de compreender a participação das comunidades amazônicas no turismo de base comunitária, buscou-se, com o objetivo central, analisar as potencialidades para o Turismo de Base Comunitária por meio da percepção turística da Comunidade Quilombola Pé do Morro. Foram estabelecidos como objetivos específicos: a) perceber o interesse e os conhecimentos da comunidade sobre o turismo, b) destacar os atrativos turísticos da comunidade sob olhar de seus membros e c) elencar os agentes sociais do turismo envolvidos na visitação de seus atrativos. Utilizou-se abordagem qualitativa para geração e análise de dados, empregando pesquisa bibliográfica, observação participante e entrevistas. Observou-se que a comunidade percebe o turismo como uma ferramenta para seu desenvolvimento, com foco nas práticas culturais e nas evidências do patrimônio cultural e natural presentes em seu território, assim como geração de renda, preservação ambiental, valorização cultural e educação das relações étnico-raciais.
Análise do consumo dos turistas otaku a partir da teoria da hipermodernidade
Authors: Brazo Dionisio de Almeida
Published: October 2023

O turismo otaku, uma vertente pouco explorada do mercado turístico nacional, engloba jovens consumidores ávidos das mídias do pop japonês, como animações (animês), histórias em quadrinhos (mangás) e cosplays. Esses entusiastas se dedicam intensamente a esses produtos, a ponto de embarcarem em viagens nacionais e internacionais em busca de aprimorar suas experiências de consumo. Desse modo, objetivamos refletir acerca do consumo do turista otaku no contexto da teoria da hipermodernidade. Em termos metodológicos, este artigo caracteriza-se como qualitativo, feito por meio de revisão bibliográfica e entrevistas semiestruturadas em formato on-line, aplicadas em 2021, com nove pessoas que já realizaram turismo focado na cultura pop japonesa. A pesquisa destaca aspectos emocionais e subjetivos do consumo realizado por esses turistas, sendo o hedonismo, a juvenilização e o ludismo axiomas importantes presentes na relação.
Main Aspects of Pharmaceutical Development of In situ Immunobiological
Drugs for Intranasal Administration
Authors: Bakhrushina Elena , Mikhel Iosif , Kondratieva Valeriya , Demina Natalia , Grebennikova Tatyana , Krasnyuk Jr Ivan , Krasnyuk Ivan
Published: October 2023

Introduction:

The review presents the latest developments in the area of intranasal in
situ delivery systems of immunobiological drugs (IBDs). Interest in intranasal administration for
IBDs has increased significantly due to the COVID-19 pandemic. However, not only intranasal
delivery of vaccines is developing, but also bacteriophages, interferons, etc. In situ systems that
make a selective phase transition can be a modern solution to intranasal delivery problems
caused by mucociliary clearance. In addition, smart-polymers used as the main excipients in in
situ systems can be used as specific adjuvants.

Methods:

A scientific search was conducted on the PubMed database of medical publications for
the period from 2000 to 2022, using the keywords "intranasal in situ vaccine"; "intranasal in situ
immunization". There were analyzed in detail more than 70 scientific studies on intranasal in situ
delivery of IBDs.

Results and Conclusions:

Despite the large number of new studies, the potential of possibilities
of intranasal in situ systems is not being realized. Based on the results of the literature review an
algorithm was created for the development of in situ systems for intranasal delivery of IBDs.
Such algorithms and the methods of study design organization described in the review will help
to facilitate the R&D process and bring the drug to commercial market, which will help to
improve the quality of medical care.
Interferon Signature’s Members, a Novel Altered Correlation upon
Interferon-β Treatment in Multiple Sclerosis Patients
Authors: Jabbari Sarvin , Hosseinpourfeizi Mohammadali , Safaralizadeh Reza , Baradaran Behzad
Published: October 2023

Background:

Multiple sclerosis (MS) is a chronic inflammatory disease that
affects the central nervous system and is characterized by extensive brain damage
and neurodegeneration. Immunological, genetic, and histological analyses of MS
patients provide data in support of the concept that autoimmunity plays a crucial role in
the condition's course. It has been proposed that MS may be treated with interferon
(IFN)-β and other members of the type I family.

Objective:

Low levels of type I IFN in MS patients may affect immunological control,
establish the threshold for an IFN therapeutic response, and be "primed" or "fixed" by
IFN therapy.

Methods:

This study was conducted as a cross-sectional study. qRT-PCR was used
to examine the expression of two critical IFN regulatory genes, IFI44 and MX1, in MS
patients receiving IFN-β treatment.

Results:

The findings demonstrated a considerable rise in the expression of both
genes in MS patients treated with IFN-β compared to those newly diagnosed with the
illness. In addition, IFI44 and MX1 might be positively associated with their expression
after IFN-β therapy and be regarded as IFN-β responsiveness indicators.

Conclusion:

The IFI44/MX1 axis could act as one of the crucial regulators of the
disease following IFN-β treatment.
Analysis of Research Publications on Pharmacogenomics of Sulphonylurea
- A Scientometric Study
Authors: Thangaraju Pugazhenthan , Chandu Himanshu Nirmal , Velmurugan Hemasri , Kannauje Pankaj Kumar , Kumar R. Arun
Published: October 2023

This study analysed pharmacogenomics studies on sulfonylurea research publications
using the Pubmed and Scopus databases. In the end, 65 publications from the years 2015 to
2021 were noticed. The objective of this study was to analyse these studies using scientometric
tools, such as frequency counts, percentages, relative growth rates, doubling times, and collectively. A maximum of 19 (29.23%) research publications were contributed during the 2020 research period. The relative growth rate tends to decrease from 2015 to 2020 and the doubling
time tends to increase and decrease after 2020. Up to 2 (3.08%) research publications were contributed by Ewan R. Pearson and Chen each. The top authors have an average degree of collaboration of 0.90 and 41 (63.83%) of their research publications are articles. The United States is
the major contributor with 19 (29.23%) pharmacogenomics research publications on sulfonylureas. Although the United States is the most prolific country in sulfonylurea pharmacogenomics
research, there are few Indian institutions that are not listed among the most prolific institutions
Value of Magnetic Resonance T1 Mapping in Evaluating the Early Response to
Treatment for Rheumatoid Arthritis
Authors: Dai Yi , Yuan Wenzhao , Chen Yidi , Lan Qiaoqing , Qin Fang , Ding Hao , Zhang Huiting , Lei Yiwu , Long Liling
Published: October 2023

Background:

Rheumatoid Arthritis Magnetic Resonance Imaging Score (RAMRIS) is usually used for the semi-quantitative evaluation of joint changes in Rheumatoid arthritis (RA). But this method is slow in evaluating changes in bone marrow edema (BME).

Objective:

To determine whether T1 mapping of wrist bone marrow edema (BME) predicts early treatment response in rheumatoid arthritis (RA).

Methods:

This study prospectively enrolled 48 RA patients administered oral anti-rheumatic drugs. MRI of the most severely affected wrist was performed before and after 4 (48 patients) and 8 weeks of treatment (38 patients). Mean T1 values of BME in the lunate, triangular, and capitate bones; RAMRIS for each wrist; erythrocyte-sedimentation rate (ESR); and 28-joint Disease Activity Score (DAS28)-ESR score were analyzed. Patients were divided into responders (4 weeks, 30 patients; 8 weeks, 32 patients) and non-responders (4 weeks, 18 patients; 8 weeks, 6 patients), according to EULAR response criteria. Receiver operating characteristic (ROC) curves were used to evaluate the efficacy of T1 values.

Results:

ESR and DAS28-ESR were not correlated with T1 value and RAMRIS (P ＞ 0.05). Changes in T1 value and DAS28-ESR relative to the baseline were moderately positively correlated with each other at 4 and 8 weeks (r = 0.555 and 0.527, respectively; P ＜0.05). At 4 weeks, the change and rate of change in T1 value significantly differed between responders and non-responders (-85.63 vs. -19.92 ms; -12.89% vs. -2.81%; P ＜0.05). The optimal threshold of the rate of change in T1 value at 4 weeks for predicting treatment response was -5.32% (area under the ROC curve, 0.833; sensitivity, 0.900; specificity, 0.667).

Conclusion:

T1 mapping provides a new imaging method for monitoring RA lesions; changes in wrist BME T1 values reflect early treatment response.
2D QSAR Modelling, Docking, Synthesis and Evaluation of 2-substituted
Benzimidazole Derivatives as Anti-breast Cancer Agents
Authors: Ramachandran Surajambika Remya , Ramesh Barath , Ramesh Ruban , Venkatesan Jaitharasan
Published: October 2023

Background:

Cancer is a leading cause of death worldwide and is anticipated to reach
28,4 million fresh cases globally by 2040. Despite all the progress made in cancer prevention,
diagnosis, and treatment, mortality by cancer is in second place.

Objectives:

The design of novel 2-substituted benzimidazole modelled by QSAR study. Molecular docking studies on the novel derivatives and synthesis characterization and evaluation of the
anticancer activity of the novel derivatives against breast cancer cell line MCF 7.

Methods:

We designed 10 novel benzimidazole derivatives modeled by 2D QSAR. From the ten
compounds by applying insilico tools of ADME properties and toxicity and through molecular
docking on Tyrosine Kinase (PDB ID: 2SRC). Compound 2AD showed the highest dock score of
-9.5 kcal/mol followed by 2 BD and 2GD (-9.3kcal/mol) Molecular dynamic simulation studies
were conducted using CABSflex an online molecular dynamic simulation tool. Six compounds
were selected for synthesis. The synthesized compounds were characterized and the invitro pharmacological activity was tested on MCF-7 cell line by MTT assay.

Results:

The compounds 2AD and 2GD showed good percentage inhibition on MCF-7 cell line
withIC50 values of 2.757 µg/ml and 2.875 µg/ml respectively.

Conclusion:

The novel 2-substituted benzimidazole derivatives are good lead compounds for
cancer therapy. Optimization of these compounds will be providing more target-specific
anticancer agents.
A Review on Emerging Impact of Antitubercular Activity of 1,2,4-Triazole
Derivatives
Authors: Rangaswamy Vedavathi , Laddi Umesh
Published: October 2023

The present review aims to summarize the antitubercular profile of 1,2,4-triazole,
one of the emerging entitled and most sought scaffold with a wide spectrum of biological and
pharmacological activities. A systematic review of literature on ‘Heterocycles’, establishes
the fact that 1,2,4-triazoles and their derivatives exhibit diverse activities. The 1,2,4-triazole
core is found in therapeutically significant drugs and many new ones are in the pipeline. ‘Triazole pharmacophore’ has replaced the widely used ‘imidazole’ as ‘systemically integral azole’ by connecting synchronicity with serendipity. Triazoles are penetratingly studied as ‘diverse therapeutic agents’, due to the improved efficacy and reduced side effects. The extensive
anthology of work carried out in the last two decades on 1,2,4-triazole moiety will provide
imminent scope for the development of novel potential drugs having better efficacy selectivity
and reduced toxicity.
Review of Sacred Herbal Medicine Aegle marmelos: A Potent Metastasis
Inhibitor
Authors: Dhamne Sagarika , Agrawal Sneha A.
Published: October 2023

Aegle marmelos (A. marmelos) appears to be a significantly used ayurvedic medicine.
This is a brilliantly composed nutritious fruit with carbohydrates, proteins, vitamins like riboflavin,
thiamine, niacin, fatty acids, and minerals. Scientific studies have proved that A. marmelos has
phytochemicals: carotenoids, phenolic, alkaloids, pectins, tannins, coumarins, flavonoids and terpenoids. Recent research on the effects of A. marmelos proved its anticancer, antimicrobial, cardioprotective, antidiabetic, and hepatoprotective activities. Extracts of various parts of plants such as
leaves, bark, stems, fruits, and pulp subjected to preclinical studies conducted on cell lines showed
apoptosis induction, inhibition of cell cycle and inhibition of proliferation of cells. Anti-cancer activity of A. marmelos was studied on selected cell lines of lung cancer, breast cancer, colon cancer
and leukaemia. A. marmelos reported significant inhibitory effect on cell proliferation in cell line
studies on A549, Ehrlich Ascites Carcinoma, MNU, DMBA, MCF-7, k562 cells, t-lymphoid Jurkat
cells, b lymphoid Raji cells, erythroleukemic Hel cells, melanoma Colo 38 cells which supports the
anticancer potential of it. Imperatorin has shown an antiproliferative effect on several cancer cell
lines. The hydroethanolic extract of A. marmelos leaves showed a decrease in cell viability on A549
Human lung cancer cell line which works by fold change over control of the β-Catenin-m RNA and
Wnt-mRNA expression of A549 and tumour growth suppression in DMBA induced carcinogenesis
in rats. In human promyelocytic leukaemia, HL-60 cells, imperatorin from A. marmelos has caused
cytochrome c-dependent apoptosis. Drugs interfere with the proliferative and survival signals that
suppress the growth of K562 cells by blocking BCR-ABL1. Proper awareness, development of
formulation and consumption of it make this drug scale up commercially.
Investigation of Antifungal Action of Fractions C17H31NO15 Isolated
from Artemisia herba-alba extract versus Isolated Aspergillus
niger from Zee maize
Authors: Amin Basma Hamdy , Ayyat Nahed Mohammed , Mohamed El-Sharkawy Reyad , Hafez Asmaa Mohamed
Published: October 2023

Background:

Plants are harmed by parasitic organisms, and toxic poisons are
created. Phytopathogenic fungi create toxins that can severely harm plants' basic physiological
functioning.

Objective:

Investigation of antifungal impact of various fractions of methanol extract of
Artemisia herba-alba to Aspergillus niger as a plant pathogen.

Methods:

Artemisia herba-alba extract was purified using column chromatography, giving
various antifungal fractions tested versus A. niger.

Results:

The 6th fraction give the highest inhibition zone with a diameter of 5.4 cm and
MIC 125.02±4.9 μg/ml, which was identified using Mass spectroscopy, 1HNMR, Elemental
analysis as well as IR testing, revealing the chemical formula of the purified fraction.
Ultrastructure alteration of treated A. niger was examined versus control using the
transmission electron microscope. Purified fraction has tested versus normal cell line with
minimal cytotoxicity.

Conclusion:

These results revealed the possibility of using Artemisia herba-alba methanol
extract as a promising antifungal versus phytopathogenic fungi, especially A. niger after
more verification of results.
Populismo contra Populismo: uma análise pragmático-discursiva sobre a polémica verbal em artigos de opinião sobre a toxicodependência em Portugal
Authors: Ninitas Mariana Silva
Published: October 2023

This paper presents the results of an exploratory work, whose main goal is to analyze the construction of verbal polemics in opinion articles about drug addiction in Portugal. Assuming that verbal polemics’ main focus is the disqualification of the opponent, and following the perspec-tives of Discourse Analysis, Pragmatics and Studies on Argumentation, we conclude that the au-thors of the texts under analysis, more than fencing arguments that support or overthrow a certain idea about drug addiction, concentrated their action on discrediting their opponent. To this end, they resorted, fundamentally, to ad personam arguments, but also ad hominem ones, attacking their opponent’s face. Complementarily, from the analyzed data, we corroborate the idea that populism – a term used several times throughout the opinion articles, including both titles – does not have a consensual definition, even though the belief that it has a negative connotation, which is why it serves as an offense to the opponent (regardless of the political quadrant). Finally, there are several traces of aggressiveness present in the articles under analysis, which seems to be reinforced by the fact that they establish a clear dialogical relationship, which starts from a critique.
Rethinking time through the episode of the Sleepers: from Aristotle to Abū’l-Barakāt al-Baġdādī
Authors: Benedetto Marienza
Published: October 2023

The article proposes to consider the use of the episode of the Sleepers in the philosophical investiga-tions on the status of time. First quoted in Aristotle’s Physics to demonstrate the dependence of time on motion, which the soul numbers, the episode is cited – through the mediation of Avicenna – in the Kitāb al-Mu’tabar or The book about what has been established by personal reflection by the philosopher of Jewish origin Abū’l-Barakāt. In his text he proposes to remodel the original history, to imagine a different scenario that accounts, ultimately, for the inevitable time–movement fracture: more than being an accident of movement, time is, in Abū’l-Barakāt’s innovative reading, the meas-ure of existence.
Alcuni utilizzi degli enti finzionali nel dibattito metafisico tra Enrico di Gand e Giovanni Duns Scoto
Authors: Falà Jacopo Francesco
Published: October 2023

The debate between Henry of Ghent and John Duns Scotus about the status of fictional beings has profound repercussions on the overall elaboration of the two thinkers’ metaphysical theories. Diffe-rent conceptions related to entities such as ‘chimera’ or ‘hircocervus’ are related to more general and different descriptions of creatural essences, and to the dynamics of the divine knowledge of these same essences, involving the determination of speculative concepts such as ratitudo, aliquitas and res a reor reris. This contribution takes into consideration the doctrines on the subject of these two authors, both readers of Avicenna, and the question 17 of the Collationes oxonienses, where a Fran-ciscan influenced by Henry of Ghent and Scotus (or one of his follower) discuss on fictional beings. A new interpretation of the collatio is given, not entirely coinciding with those found in secondary literature.
Evidências de validade da escala de motivação de professores para o trabalho
Authors: Inácio Amanda Lays Monteiro , Mariano Maria Luzia Silva , Bzuneck José Aloyseo
Published: October 2023

Este estudo teve por objetivo estimar indicadores de validade com base na estrutura interna e precisão da Escala de Motivação do Professor para o Trabalho, por meio de uma Análise Fatorial Confirmatória (AFC). Participaram 452 docentes de diferentes etapas de ensino e regiões do país. A média de idade foi de 41 anos e 7 meses (DP = 10,2), variando de 18 a 66 anos, com predominância do gênero feminino (77,9%). Os resultados da AFC indicaram a presença das quatro dimensões, conforme mencionado na literatura científica, com índices de consistência interna considerados aceitáveis e bons índices de ajuste do instrumento. Foram encontradas correlações positivas e negativas entre os fatores, todas significativas. Por fim, os professores se mostraram mais motivados autonomamente. Os resultados evidenciam importantes contribuições à área psicoeducacional, com bons indicadores psicométricos do instrumento para avaliação do construto motivacional relacionado ao trabalho docente.
The “Turnkey School” project model for teacher team training
Authors: Nechaev Vladimir , Avdeeva Irina
Published: October 2023

This study aims to present a new model of professional training for teachers in educational institutions within the framework of the "Turnkey School" project within the Master of Education degree program at the Humanitarian and Pedagogical Institute of Sevastopol State University (SevSU). This study used a controlled research design method to validate the team concept through a proposed model based on the socio-constructivist and contextual paradigms in education. The model involves training in a master's program as part of team building for a new educational institution in which cohort groups are formed based on the specific needs of assigned schools, which are then evaluated by an independent community of experts, as well as with the writing of a final thesis as a result of cohort team collaboration. This study confirms that the cohort group formed through this model shows a better level of maturity and functioning than randomly assigned teachers. These findings support the effectiveness of a Master of Education degree in improving the training and performance of future teachers. This model emphasizes not only the creation of updated educational products but also the self-implementation of those products, which contributes to the overall improvement of educational institutions.
Technology-based pragmagogy competency assessment to measure teachers' ability in classroom management
Authors: Rohmadi Muhammad , Sudaryanto Memet , Prayitno Harun Joko , Zainnuri Hasan
Published: October 2023

Teachers' classroom management skills can be seen in their language teaching skills. This study aimed to (1) develop an online assessment model to measure teachers' pragmagogy ability in Indonesia and (2) measure teachers' ability to respond to pragmagogy-related stimuli. This study uses a DD approach to answer the problem formulation determined during model design, development, and evaluation. The sample included 3,150 primary, secondary, and advanced Indonesian teachers. Functionality, reliability, usability, efficiency, maintainability, and portability were validated. This study explained the formulated pragmagogy construction through exploratory factor analysis. Stress testing and installation testing were used to broaden the application's reach. Based on the initial analysis, the online assessment model concludes that the teacher's pragmagogy ability can determine knowledge, skills, and attitudes. Teachers' pragmagogy ability can be determined through pedagogic knowledge as the framework for roles and figures in the form of thinking; reflective and emotional intelligence; ability in instructional communication patterns; and other aspects to realize pragmagogic competence. The use of pragmagogy measurement applications can examine various approaches chosen by teachers to maximize the teaching-learning process in the classroom through interactive, responsive, persuasive, implicative, locution, illocution, perlocution approaches to describe the pragamagogical competencies possessed by teachers in classroom management that is interesting and fun for their students.
Improving learning outcomes: The effectiveness of e-book reading literacy based in learning management psychology
Authors: Jasrial Jasrial , Saputra Andra , Rifma Rifma
Published: October 2023

The research aims to improve learning outcomes of Management Psychology Courses use E-book teaching material reading literacy based for the student of the Education Administration Study Program, Faculty of Education, Universitas Negeri Padang, Indonesia. The research used 2 x 2 factorial design experimental methods with ANOVA. The research obtained the highest score 96.6 for experimental class, and 93.3 for control class. The students learning outcomes in the experimental class have an average 81.93 and average 71.75 for control class. The result of t-test for both of class, tcount was 5.11 and ttable was 1.66. It implied there was a significant difference about students learning outcomes. The learning outcomes of student that used E-book teaching material was higher than students that used printed teaching materials. The students who have high reading literacy and used E-book teaching material, the student learning outcomes was higher than the student who have high reading literacy but used printed materials. And the students who have low reading literacy and used E-book teaching material, the learning outcomes was higher than the students who have low reading literacy but used printed teaching material.
Estetik relevance Beksan Menak Sudarawerti Sertupelaeli towards character education
Authors: Herawati Enis Niken , Widyastutieningrum Sri Rochana , RM. Pramutomo RM. Pramutomo , Slamet Slamet
Published: October 2023

Beksan Menak Sudarawreti Sirtupelaeli is a show that comes from the Javanese Palace. This dance is Yasan Dalem (creation) Sri Sultan Hamengkubuwaao IX. Beksan Menak Sudarawerti Sirtupelaeli is a performance that has a unique one of which lies in his dance moves.Revitalization of Estetik Beksan Menak Sudarawreti Sirtupelaeli to Develop Character Education is research with qualitative methods, namely by describing the Aesthetic Revitalization of Beksan Menak Sudarawreti Sirtupelaeli to Develop Character Education in detail. The study used primary and secondary data sources. The primary data source is the interview record. The researcher's secondary data sources were obtained through literature studies in the form of books, scientific journals that support research, and photo documentation of dance movement variations, Sudarawreti Sirtupelaeli kostrum. Data collection techniques are carried out with observation, interview, document study and literacy techniques.Understanding and knowing the aesthetics in the movement of Beksan Menak Sudarawreti Sirtupelaeli and knowing its relevance to character education is the purpose of this research. Based on the analysis of the data conducted, it was concluded that in the movement of Beksan Menak Sudarawreti Sirtupelaeli there are aesthetic values that contain meanings that are in accordance with the values of character education. Beksan Menak Sudarawreti Sirtupelaeli also has a relationship with the context of art and education as a guideline for daily life or values that contain noble ethics that are worth knowing. Keywords: Beksan Menak, Sudarawreti Sirtupelaeli, aesthetics, character education.