bluuebunny/crossref_metadata_2025 huggingface dataset:
Evidence-based Medicine: A Narrative Review on the Evolving Opportunities and Challenges
Authors: Agrawal Shreyash , Magoon Rohan , Choudhary Nitin , Suresh Varun , Kumar Ashok , Nagpal Vijay Kumar , Kaur Mohandeep
Published: November 2023

Evidence-based medicine (EBM) undeniably classifies as a pre-eminent advance in the clinical approach to decision-making. Although EBM as a topic has been discussed at length, it is more about the process of integrating EBM into practice, wherein the actual debate becomes even more interesting with unique roadblocks cropping up at the very end of the translational highway. Meanwhile, the core concept of EBM has stood firm over decades; it is likely the research landscape and the corresponding intricacies continue to evolve at a rather rampant pace. Evidence-based practice is thus best elaborated in close conjunction with the recent advent of precision medicine, the impact of the coronavirus disease 2019 pandemic, and the ever-compounding present-age research concerns. In this reference, the randomized controlled trials and now the meta-analysis (second-order analysis of analyses) are also being increasingly scrutinized for the contextual veracities and how the quality of the former can be rendered more robust to strengthen our epic pyramid of EBM. Withstanding, the index narrative article is a modern-day take on EBM keeping abreast of the evolving opportunities and challenges, with the noble objective of deliberating a standpoint that aims to potentially bridge some of the existing gaps in the translation of research to patient care and outcome improvement, at large.
Clinical relevance of gibberellin-regulated protein
Authors: Lavric Cătălina-Elena , Berghea Camelia Elena
Published: November 2023

Since 2013, a total of nine allergenic sources of gibberellin-regulated protein (GRP) have been described in the literature. The first gibberellin-regulated protein considered to be an allergen was extracted from peach (Prunus persica) and was named Pru p 7. This article aims to provide an overview of the GRP’s characteristics, to emphasize their importance and relevance in clinical practice, and to bring to attention the methods of diagnosis and treatment proposed in the literature published to date. After certain fruit consumption in patients sensitized to GRP, it has been described the occurrence of allergic reactions of various degrees (oral allergy syndrome, up to severe anaphylactic reactions). This fact raises a series of questions regarding the clinical expression of this sensitization, but also confers a change of perspective in relation to fruit allergy. At this moment, it is not clear if the sensitization to food GRP is always a primary sensitization or if the sensitization to food GRP appears subsequent to sensitization to Cupresaceae pollen’s GRP. Pru p 7 is considered to be a potential marker of severity in case of sensitization to peach allergens. Furthermore, the presence of cofactors in GRP sensitized patients may induce systemic allergic reactions. The diagnosis of this type of allergy might be difficult, and the personalized treatment is not yet available.
Flexible Nanogenerators based on Enhanced Flexoelectricity in Mn3O4 Membranes
Authors: Gowda Chinmayee , Cavin John , Kumbhakar Partha , Tiwary Chandra Sekhar , Mishra Rohan
Published: November 2023

Atomically thin, few-layered membranes of oxides show unique physical and chemical properties compared to their bulk forms. We have exfoliated manganese oxide (Mn3O4) membranes from the naturally occurring mineral Hausmannite and used them to make flexible, high-performance nanogenerators. We observe an enhanced power density in the membrane nanogenerators (NG) with the best-performing device showing a power density of 7.99 mW m-2 compared to 1.04 µW m-2 obtained from NG made up of bulk Mn3O4. We also observe a sensitivity of 108 mV kPa-1 for applied forces < 10 N in the membrane NGs. We attribute the improved performance of these NGs to enhanced flexoelectric response in few-layers of Mn3O4. Using first-principles calculations, we calculate the flexoelectric coefficients of monolayer and bilayer Mn3O4, and find them to be 50 – 100 times larger than other two-dimensional transition metal dichalcogenides (TMDCs). Using a model based on classical beam theory, we find increasing activation of the bending mode with decreasing thickness of the oxide membranes, which in turn leads to a large flexoelectric response. As a proof-of-concept, we made flexible nanogenerators using exfoliated Mn3O4 membranes and used them in self-powered paper-based devices. This research paves the way for the exploration of few-layered membranes of other centrosymmetric oxides for application as energy harvesters.
Toward Three-dimensionally Ordered Nanoporous Graphene Materials: Template Synthesis, Structure, and Applications
Authors: Yamamoto Masanori , Goto Shunsuke , Tang Rui , Yamazaki Kaoru
Published: November 2023

Precise template synthesis will realize three-dimensionally ordered nanoporous graphenes (NPGs) with a spatially controlled seamless graphene structure and fewer edges. These structural features result in superelastic nature, high electrochemical stability, high electrical conductivity, and fast diffusion of gases and ions at the same time. Such innovative 3D graphene materials are conducive to solving energy-related issues for better future. To further improve the attractive properties of NPGs, we review the template synthesis and its mechanism by chemical vapor deposition of hydrocarbons, analysis of nanoporous graphene structure, and applications in electrochemical and mechanical devices.
Non-covalent Functionalized Schottky Interface at Ti3C2Tx/n-Si Van der Waals Heterojunction
Authors: Ros Costals Eloi , Francesc Cappela Xavier , Tom Thomas , Giraldo Sergio , Placidi Marcel , Voz Cristobal , Puigdollers Joaquim , Saucedo Edgardo , Jehl Li Kao Zacharie , Tiwari Kunal Jogendra
Published: November 2023

Low dimensional 2D materials such as graphene and carbon nano tubes have attracted significant attention from the solid-state device community and are considered as a potential candidate electrode to make functional contact with the Silicon (Si) and other industry compatible semiconductors. In this work we envisioned to utilize one such interesting 2D material Ti3C2Tx belonging to a rapidly emerging family of transition metal carbides/nitrides also known as MXene´s to fabricate the classical yet interesting Schottky junctions by simple drop casting of aqueous conducting colloidal solution of Ti3C2Tx on c-Si. Precisely, we anticipate to tune the work function of the Ti3C2Tx as well as the built-in potential of these Ti3C2Tx/c-Si Van der Waals heterojunction through inserting ultrathin interlayer of cationic polyelectrolytes/organic dipoles with a defined dipole moment value. In order to accomplish the interface engineering inclusion poly(ethylene)amine (PEI 0.1%), third generation poly(amido-)amine (PAMAM G3)), were tested between the Ti3C2TX and c-Si substrates. Charge transport properties of the fabricated Schottky devices with the structure of Ti3C2TX/organic dipole (O.D.) /c-Si were evaluated through systematic analysis of the current-voltage (I-V) and capacitance-voltage (C-V) results. I-V measurements under dark conditions revealed that Schottky diodes fabricated with the (PEI 0.1%) and PAMAM G3 interlayers exhibited lowest reverse saturation current density (J0) value and improved built in potential (Vbi) value as compared to the devices with only 2D-Ti3C2Tx as contact. We report reduction in the work function value of Ti3C2Tx from 5.8 eV to 4.2 eV for Ti3C2Tx/PEI (0.1%) and 3.3 eV for Ti3C2Tx/PAMAM G3 heterostructures. On the basis of the inferences drawn from the surface analysis we ascribe this reduction in work function value to the formation of interfacial dipoles at the Ti3C2Tx/O.D. interface. Importantly this study highlights an innovative method to tune the work function of the Ti3C2Tx MXene inclusion of organic dipoles as interlayers.
Redox behaviour of Cu-Aβ(4-16) complexes related to Alzheimer's Disease
Authors: Wiloch Magdalena , Linfield Steven , Baran Natalia , Nogala Wojciech , Jönsson-Niedziółka Martin
Published: November 2023

The development of Alzheimer’s Disease (AD) has been linked to abnormal quantities of β-amyloid peptides in the brain. The majority of studies have focussed on Aβ(1-40/42) amyloids and their Cu(II)-Aβ(1-40/42) complexes which are responsible for production of reactive oxygen and nitrogen species (ROS and RNS), which are highly toxic to neurons. According to recent studies on amyloid plaques, Aβ(4-42), which is an N-truncated version of Aβ(1-42), is as prevalent as Aβ(1-42) in the brain. Although Cu(II) ions, bounded by Aβ(4-42), can be oxidized to highly reactive Cu(III) ions, its Cu(II) complexes do not appear to contribute to ROS/RNS formation. In this paper, the pH-dependent voltammetric response of Aβ(4-16)-Cu(II) complexes is investigated to understand the influence of the deprotonation of tyrosine within the complex towards the Cu(II)/Cu(III) reaction. The results will help to better understand the scavenging role of tyrosine in quenching highly reactive Cu(III) ions not only in Aβ(4-x)-Cu(II) complexes but also provide clues to the reactive properties of other tyrosine-containing amyloid-metal complexes.
DSDPFlex: An Improved Flexible-Receptor Docking Method with GPU Acceleration
Authors: Dong Chengwei , Huang YuPeng , Lin Xiaohan , Zhang Hong , Gao Yi Qin
Published: November 2023

Virtual screening constitutes an indispensable phase in the pharmaceutical industry. Among the different methods, the most popular docking strategy, semi-flexible docking (rigid-receptor and flexible-ligand model), ignores the conformational changes of proteins. When the binding interaction between ligands and proteins adheres to an "induced-fit" paradigm, fully flexible methods such as molecular dynamics simulation are needed, but they can be computationally demanding. In an effort to strike a balance between computational speed and precision, flexible docking techniques, as exemplified by AutoDock Vina and AutoDockFR, treat selected protein side chains as flexible parts. However, these methods are still not fast enough in high throughput virtual screening tasks, and some of the algorithms are not specifically optimized for flexible-receptor sampling. In this work, we propose DSDPFlex, an improved receptor-flexible docking method. We accelerated the flexible docking process using GPU parallelization. We also implemented optimizations with respect to sampling, scoring, and search space to prevent redundant search and false-positive solutions, to further improve the efficiency and accuracy. To estimate the performance of DSDPFlex, a cross-docking dataset was constructed. Upon cross-docking tests, DSDPFlex obtained a 19.1% top-1 success rate, which is higher than AutoDock Vina, and the average runtime is ~1 second per task, representing a ~250-fold acceleration with respect to Vina. The generalizability of the method is validated on other commonly used test sets; the adaptability to different systems is also discussed. With improvement in both speed and accuracy, DSDPFlex is expected to show potential in docking-based studies.
Exploration of Biochemical Reactivity with a QM/MM Growing String Method
Authors: McFarlane Neil , Harvey Jeremy
Published: November 2023

In this work, we have implemented the single-ended growing string method using a hybrid internal/Cartesian coordinate scheme within our in-house QM/MM package, QoMMMa, representing the first implementation of the growing string method in the QM/MM framework. The goal of the implementation was to facilitate generation of QM/MM reaction pathways with minimal user input, and also to improve the quality of the pathways generated as compared to the widely used adiabatic mapping approach. We have validated the algorithm against a reaction which has been studied extensively in previous computational investigations – the Claisen rearrangement catalysed by chorismate mutase. The nature of the transition state and the height of the barrier was predicted well using our algorithm, where more than 88% of the pathways generated were deemed to be of production quality. Directly compared to using adiabatic mapping, we found that while our QM/MM single-ended growing string method is slightly less efficient, it readily produces reaction pathways with fewer discontinuites and thus minimises the need for involved remapping of unsatisfactory energy profiles.
Fabrication and Characterization of Tamarind gum–Hydroxypropyl-beta-cyclodextrin-based semi-interpenetrating hydrogel network and In-vitro release of Moxifloxacin
Authors: Sharma Vivek , Pal Kunal , Mateti Tarun , Thakur Goutam
Published: November 2023

Interpenetrating networks of hydroxypropyl-beta-cyclodextrin have shown great potential as drug carriers showing controlled release characteristics. In this study, we report the formation of a semi-interpenetrating hydrogel network between tamarind gum and hydroxypropyl-beta-cyclodextrin for the sustained release of moxifloxacin. The prepared hydrogels were characterized for their morphology, crystal structure, chemical composition, electrical, mechanical, drug release, and antibacterial properties. Microscopic studies revealed the formation of globular structures that were concentration dependent. XRD and FTIR studies indicated the hydrogen bonding among the TG–HPβCD molecules and rendered the formation of IPN. Electrical and mechanical studies revealed that the properties of the hydrogels were highly dependent on the HPβCD concentration. The in-vitro drug release depicted non-Fickian behavior of the drug release. Antibacterial studies revealed that the drug was actively released from the IPN system and was effective against Escherichia coli.
Discovery of red-shifting mutations in firefly luciferase using high-throughput biochemistry
Authors: Colee Clair M. , Oberlag Nicole M. , Simon Marcell , Chapman Owen S. , Flanagan Lyndsey C. , Reid-McLaughlin Edison S. , Gewing-Mullins Jordan A. , Maiche Synaida , Patel Devi F. , Cavalcanti Andre R.O. , Leconte Aaron M.
Published: November 2023

The Photinus pyralis luciferase (FLuc) has proven a valuable tool for bioluminescence imaging, but much of the light emitted from the native enzyme is absorbed by endogenous biomolecules. Thus, luciferases displaying red-shifted emission enable higher resolution during deep-tissue imaging. A robust model of how protein structure determines emission color would greatly aid the engineering of red-shifted mutants, but no consensus has been reached to date. In this work, we apply deep mutational scanning to systematically assess twenty functionally important amino acid positions on FLuc for red-shifting mutations, predicting that an unbiased approach would enable novel contributions to this debate. We report dozens of red-shifting mutations as a result, a large majority of which have not been previously identified. Further characterization revealed that mutations L286V and T352M, in particular, cause pure red emission with much of the light being >600 nm. The red-shifting mutations identified by this high-throughput approach provide strong biochemical evidence for the multiple-emitter mechanism of color determination, and point to the importance of a water network in the enzyme binding pocket for altering the emitter ratio. This work provides a broadly applicable mutational data set tying FLuc structure to emission color that informs our mechanistic understanding of emission color determination and should facilitate the further engineering of improved probes for deep-tissue imaging.
Analysis of the indispensable RAD51 cofactor BRCA2 inNaganishia liquefaciens, a Basidiomycota yeast
Authors: Palihati Maierdan , Iwasaki Hiroshi , Tsubouchi Hideo
Published: November 2023

TheBRCA2tumor suppressor plays a critical role in homologous recombination by regulating RAD51, the eukaryotic homologous recombinase. We identified the BRCA2 homolog in a Basidiomycota yeast,Naganishia liquefaciens. BRCA2 homologs are found in many Basidiomycota species but not in Ascomycota species.NaganishiaBRCA2 (Brh2, forBRCA2homolog) is about one-third the size of human BRCA2. Brh2 carries three potential BRC repeats with two oligonucleotide/oligosaccharide-binding domains. The homolog of DSS1, a small acidic protein serving as an essential partner of BRCA2 was also identified. The yeast two-hybrid assay shows the interaction of Brh2 with both Rad51 and Dss1. Unlike human BRCA2, Brh2 is not required for normal cell growth, whereas loss of Dss1 results in slow growth. The loss of Brh2 caused pronounced sensitivity to UV and ionizing radiation, and their HR ability, as assayed by gene-targeting efficiency, is compromised. These phenotypes are indistinguishable from those of therad51mutant, and therad51 brh2double mutant.NaganishiaBrh2 is likely the BRCA2 ortholog that functions as an indispensable auxiliary factor for Rad51.
Are Savior Siblings a Special Case in Procreative Ethics?
Authors: Althorpe Caleb , Finneron-Burns Elizabeth
Published: November 2023

In this paper we examine three categories of reasons that have been given against the creation of savior siblings (harm to the child, autonomy violations, and effects on wider society) and argue that all can be defeated. We then outline the conditions under which the practice is morally permissible and argue that these conditions are no different from those under which it is ever morally permissible to procreate. Our surprising conclusion is that savior siblings do not present a special case in procreative ethics and it is permissible to create them whenever it is permissible to create any other child.
The Case for Voting to Change the Outcomes Is Weaker Than It May Seem: A Reply to Zach Barnett
Authors: Liron Amir , Enoch David
Published: November 2023

Because you are highly unlikely to cast the deciding vote in the next elections, it is often said that you don’t have a reason to vote in order to change the outcomes. In a recent paper, however, Zach Barnett forcefully argues that this is a mistake. He shows how it follows, from rather conservative assumptions, that in many real-life cases the expected social value of voting is higher than its cost.
Barnett is successful, we believe, in showing that the commonly held belief – that voters do not have a reason to vote in order to change the outcomes – is way too hasty. However, Barnett is – we argue in this paper – too quick on one key premise, and once this is noticed, it becomes unclear how often Barnett’s reasoning can point to a justification of voting to change the outcomes. Barnett’s reasoning, we conclude, may apply to significantly less real-life scenarios than he suggests.
Revista de moda: um estudo sobre os desafios e caminhos do jornalismo segmentado a partir da perspectiva dos editores
Authors: Bueno Thaisa , Fonseca Barros Jordana , Alves Marcelli
Published: November 2023

Este artigo propõe a entender os desafios e os caminhos do jornalismo de moda nacional no ciberespaço a partir da perspectiva de editores que atuam em revistas. O recorte documental de pesquisa são as respostas dos editores de revistas (web revistas ou revistas com forte tradição impressa), publicadas em formato de entrevista no “Especial: O que o impresso tem que o digital não pode oferecer?”, de agosto de 2019 na página da FFW. Ao todo são oito entrevistados que representam revistas como Vogue, Elle, Marie Claire, L’Officiel, Glamour, FFW, Made in Brazil e 55+Mag e Fort. O manuscrito escolhido como recorte desta pesquisa justifica-se porque documenta uma discussão importante para atualidade midiática e os sujeitos/respondentes são profissionais de veículos prestigiados no setor. Além disso, a conversa transcrita é uma oportunidade de conhecer o que os produtores/ editores de conteúdo jornalístico segmentado pensam sobre questões cabais para a prática profissional, cujas reflexões não são facilmente encontradas de forma sistemática, o que se mostra uma boa oportunidade para entender e tensionar tais apontamentos com autores que pensam o jornalismo na atualidade. Para dar conta dessa proposta analítica, adotou-se com metodologia a Análise de Conteúdo (Bardin, 2011; Janis, 1982; Franco, 2005) e seu protocolo detalhado. Conclui-se, entre outros, que é necessária a remodelagem do modelo de negócio nas revistas de moda baseadas nos impactos das lógicas comerciais e estruturais da cibercultura.
O campo da Moda entre atravessamentos e transversalidades
Authors: Borges Rufino Carina , Bonadio Maria Claudia
Published: November 2023

Chegamos ao fim de mais um ano com a satisfação de poder contribuir, cada vez mais, para o fortalecimento da cultura acadêmico-científica de moda no Brasil e no exterior. Sendo assim, anunciamos a edição 39 da dObra[s], a última de 2023, que chega aos leitores com a excelência do trabalho dedicado pelas pesquisadoras Joana Bosak (Universidade Federal do Rio Grande do Sul) e Ana Carolina Acom (Universidade Federal de São João del-Rei/Universidade Estadual do Oeste do Paraná) ao dossiê “O Campo da Moda atravessado: do portátil ao expandido”. [...]
Uma história dos trajes - e mais - pelos traços do jovem Victor Meirelles
Authors: Bosak Joana
Published: November 2023

Logo no início do capítulo I de O tecelão dos tempos, o historiador Durval Muniz Albuquerque Junior2 cita o francês Michel de Certeau3 , que pergunta: “o que fabrica o historiador quando faz história?” Segundo o brasileiro, de Certeau aí apresenta o historiador, em primeiro lugar, como um trabalhador, e a fabricação de uma narrativa, de um “artefato escriturístico”, como “um trabalho de fabricação dos acontecimentos do passado” (Albuquerque Jr., 2019, p. 27). [...]
Deep learning for enhancing internet of things: A comprehensive survey
Authors: Ushaa Eswaran , Vishal Eswaran
Published: November 2023

The Internet of Things (IoT) has emerged as a transformative technology, connecting a wide range of devices and sensors to the internet, enabling data-driven decision-making and automation across various domains. Deep learning, a subset of machine learning, has played a pivotal role in advancing IoT applications by providing the means to process and interpret the massive volumes of data generated by IoT devices. This comprehensive survey provides an extensive review of the integration of deep learning techniques with IoT, aiming to offer a holistic understanding of the state-of-the-art research and practical implementations. The key motivations include handling complex IoT data and enabling smart applications across domains like healthcare, transportation, and industry 4.0. Real-world case studies demonstrate significant improvements on metrics like prediction accuracy, operational efficiency, and energy savings. The adoption of edge computing is further driven by the need to reduce latency in data processing and enhance real-time decisionmaking capabilities in these critical sectors. However, challenges remain around model interpretation, robustness, and computational complexity. Future IoT systems must focus on lightweight deep learning architectures tailored for edge devices, distributed and privacy-preserving analytics, and improved model transparency and fairness. Additionally, these future IoT systems should prioritize robust security measures to protect sensitive data and ensure the reliability and integrity of connected devices and networks. A systematic framework is proposed covering data curation, model development, deployment, and monitoring to guide adoption. The comprehensive nature of this survey aims to bridge the gap between theoretical knowledge and practical deployment, enabling a smoother integration of deep learning into IoT systems. By offering a structured overview of best practices and emerging trends, it empowers professionals to make informed decisions in their IoT projects.
Reform of the Teaching Model of Korean Intensive Reading Courses in Vocational High Schools in the Era of All-Media
Authors: Chen Ruoxuan
Published: November 2023

The use of multimedia technology in the teaching process is the current mainstream trend in teaching development. The arrival of the all-media era is not only a huge challenge to the traditional teaching model, but also a huge opportunity for the reform of the teaching model. Combining traditional education models with modern scientific and technological means, and learning from each other’s strengths can stimulate students’ subjective initiative in learning. On the other hand, it is also an important way for teachers to improve their teaching abilities. This article analyzes the opportunities brought by the all-media era to the reform of education models based on the teaching status and teaching difficulties of Korean intensive reading courses in vocational high schools, and proposes a teaching model reform strategy for Korean intensive reading courses in vocational high schools in the all-media era.
Analyzing the Influences on Women’s Upbringing and Their Educational Significance Using the Case of Estella, the Heroine of Great Expectations
Authors: Yang Xiaoyi
Published: November 2023

This paper explores the influences on women’s upbringing and their educational significance by using the character Estella from Great Expectations as a case study. Through analyzing the impact of social environment, family education, and self-awakening, this article aims to promote gender equality and the construction of a feminist cognitive community. It delves into the class divisions of 19th-century England, the manipulative family education imposed on Estella by Miss Havisham, and Estella’s journey towards self-consciousness after her foster mother’s death. The study highlights the challenges faced by women in societal constraints, family expectations, and the importance of self-discovery in overcoming these limitations.
Change of Organizational and Production Paradigms in the IT Industry: Research 2020–2023
Authors: Pashchenko D. S.
Published: November 2023

The experience of creating successful geographically distributed engineering teams and the COVID pandemic have made a significant contribution to the dynamics of changing the organizational and production paradigm in the IT industry from the traditional 40-hour office work to a “hybrid” work week and even to completely remote software and IT-services development. In this study, the scientific task of determining the nature of the process of paradigm shift is set and a set of scientific hypotheses is set to identify fully remote work as an established practice for a significant number of leading IT companies in Europe. To test these hypotheses, thematic industry studies of 2020–2023 were analyzed, which convincingly proved that the forced transition to completely remote development during lockdown periods and after reducing the impact of pandemic risks becomes a conscious choice: in demand, economically rational, supported by a significant number of engineers and managers in the industry. At the same time, a “hybrid” work week, combining part of the days in the office and part outside it, has also remained a popular option for organizing work in IT companies and organizations with large teams for internal automation.
New Instruments for Investment Support of Technology Sovereignty Projects
Authors: Sokolov A. B. , Filatov V. I.
Published: November 2023

The growth of restrictive measures against the Russian Federation in the context of the high import dependence of the national economy calls for special attention to be paid to the country’s achievement of technological sovereignty and the launching of a new sustainable investment cycle. This involves the task of dynamically increasing the creation of new medium- and high-technology industries, with a central role being given to the creation of a resource database of projects. Limited public budgets and the inaccessibility of external financial markets make it appropriate to consider domestic private and (or) resources as priority sources of financing debt, especially when the latter are not sufficiently involved in the investment process. In turn, it is unlikely to accumulate the funds of credit organizations and the business sector without the use of modern state support tools that would reduce the cost of capital for the implementation of investment projects and, thus, they redirected financial flows to the highest priority, albeit low-margin, of the real sector. Thus, the purpose of this article is to analyze new instruments of investment support of projects of ensuring technological sovereignty in the territory of the Russian Federation.
Importancia de los genes HOX en enfermedades humanas
Authors: Serrano Clara
Published: November 2023

Los genes Homeobox, reguladores maestros que participan en la formación del plan corporal y dirigen el desarrollo de estructuras o segmentos   corporales particulares, codifican proteínas homeóticas que actúan como factores de transcripción específicos, tienen en común una secuencia de nucleótidos conservada de 180 pb llamada caja homeótica, traducida en 61 aminoácidos, conocida como homeodominio, implicado en la unión al ADN.  En el ser humano el ordenamiento de los genes dentro de cada complejo HOX, es igual al complejo HOM que se encuentra en Drosophila melanogaster, lo que indica que se originaron por duplicaciones de un solo complejo primordial, el mismo que ha conservado su organización básica.  Los genes HOX, pertenecen a la categoría de genes rectores, ya que controlan la expresión de genes subordinados, desempeñando un papel importante en la morfogénesis y diferenciación celular durante el desarrollo embrionario; además participan en procesos de control de la proliferación celular   y muerte celular programada. Numerosos estudios clínicos y moleculares han demostrado que mutaciones   derivadas en alteraciones de su expresión, estarían relacionadas en la génesis del cáncer, invasión y metástasis.
PERAN KOMITE SEKOLAH DALAM IMPLEMENTASI PRINSIP MANAJEMEN BERBASIS SEKOLAH DI TK PERJUANGAN DESA KLUWIH KECAMATAN BANDAR KABUPATEN BATANG
Authors: Budiarti Budiarti , Haryati Titik , Yuliejantiningsih Yovitha
Published: November 2023

Abstrak Hasil penelitian 1) peran komite sekolah sebagai pemberi pertimbangan dalam implementasi prinsip MBS di TK kanak Perjuangan adalah memberikan pertimbangan berbagai program sekolah. Bentuk pertimbangan itu seperti membarikan masukan dalam perspektif anggaran, sarpras, pengelolaan pembelajaran, kemitraan dengan instansi dan orang tua peserta didik. 2) Peran komite sekolah sebagai pendukung dalam implementasi prinsip. Bentuk dukungan materi berupa penggalangan dana dari masyarakat, dukungan dalam bentuk tenaga diwujudkan dalam kerja bakti bersama, dan dukungan dalam bentuk pemikiran. 3) peran komite sekolah sebagai pengontrol dalam implementasi prinsip manajemen berbasis sekolah di TK Perjuangan dilakukan dalam bentuk pengawasan baik secara langsung maupun tidak langsung dalam laporan akhir tahun. 4) Peran komite sekolah sebagai mediator dalam implementasi prinsip MBS di TK Perjuangan dilakukan dengan menjadi jembatan penghubungan antara sekolah dengan masyarakat dan instansi lain. Peran sebagai mediator ini dalam rangka membantu sekolah mengsukseskan pelaksanaan MBS dengan semua prinsipnya.
IMPLEMENTASI SUPERVISI AKADEMIK DALAM MENINGKATKAN KEEFEKTIFAN PEMBELAJARAN DI SD NEGERI
Authors: Nugrahini Agustina , Haryati Titik , Sudana I Made
Published: November 2023

ABSTRAK Hasil penelitian 1) Perencanaan supervisi yang dilakukan kepala sekolah untuk meningkatkan mutu sekolah di SD Negeri Kalisari 1 Sayung Demak meliputi: pembentukan tim supervisor, pembuatan jadwal supervisi, menyusun program supervisi, penyusunan instrumen supervisi, melakukan sosialisasi program supervisi. Tahap perencanaan ini dibantu oleh tim supervisi. Pada tahap perencanaan ini didesain pada aspek penilaian mutu pembelajaran.2) Proses pelaksanaan supervisi yang dilakukan kepala sekolah untuk meningkatkan mutu sekolah di SD Negeri Kalisari 1 Sayung Demak pertama, praobservasi, kemudian observasi melalui kunjungan kelas, penilaian, pemberian bimbingan dan pengarahan meskipun bimbingan dan pengarahan ini juga melalui beberapa cara baik individu maupun kelompok. Pada pelaksanaan tersebut kepala sekolah dibantu oleh tim supervisi, dari hasil supervisi kemudian akan dilaporkan kepada sejumlah dewan guru dan dilakukan pengarahan bersama untuk meningkatkan mutu pembelajaran.3) Tindak lanjut kegiatan supervisi yang dilakukan kepala sekolah untuk meningkatkan mutu sekolah di SD Negeri Kalisari 1 Sayung Demak dilakukan secara langsung dan tidak langsung. Pembinaan langsung maupun pembinaan tidak langsung. Pembinaan langsung adalah pembinaan yang dilakukan terhadap hal-hal bersifat khusus, yang perlu perbaikan dengan segera dari hasil analisis supervisi. Dan pembinaan tidak langsung adalah pembinaan yang dilakukan terhadap hal-hal bersifat umum yang perlu perbaikan dan perhatian setelah memperoleh hasil analisis supervisi. Saran: kepala sekolah perlu melakuan supervisi secara terjadwal agar guru memiliki kesiapan dahulu.
PENGARUH KEPEMIMPINAN KEPALA SEKOLAH, BUDAYA SEKOLAH DAN KOMITMEN KERJA TERHADAP DISIPLIN GURU DI SMAN KABUPATEN KENDAL
Authors: Ramani Ramani , Haryati Titik , Sudana I Made
Published: November 2023

Abstrak Rumusan masalah penelitian ini adalah: (1) Adakah pengaruh kepemimpinan kepala sekolah terhadap disiplin guru di SMA Negeri Kabupaten Kendal?, (2) Adakah pengaruh budaya sekolah terhadap disiplin guru di SMA Negeri Kabupaten Kendal?, (3) Adakah pengaruh komitmen kerja guru terhadap disiplin guru di SMA Negeri Kabupaten Kendal?, (4) Adakah pengaruh secara bersama sama antara kepemimpinan kepala sekolah, budaya sekolah dan komitmen kerja terhadap disiplin guru di SMA Negeri Kabupaten Kendal? Populasi penelitian ini 573 guru di Sekolah Menengah Atas Negeri Kabupaten Kendal. Sampel 236 guru diambil secara proporsionale random sampling. Pengumpulan data menggunakan kuesioner. Pengolahan data untuk uji validitas, uji reliebilitas, uji persyaratan dan uji hipotesis menggunakan program SPSS for Windows 21. Hasil penelitian menunjukkan bahwa: (1) Ada pengaruh kepemimpnan kepala sekolah terhadap disiplin guru sebesar 57,2% dengan kontribusi tertinggi dari dimensi disiplin peraturan organisasi dan kontribusinya paling rendah adalah pada dimensi disiplin peraturan kerja. (2) Ada pengaruh budaya sekolah terhadap disiplin guru sebesar 37,1% dengan kontribusi tertinggi dari dimensi supervisi dan kontribusinya paling rendah adalah pada dimensi manajerial. (3) Ada pengaruh komitmen kerja terhadap disiplin guru sebesar 27,2% dengan kontribusi tertinggi dari kontribusi adalah dimensi komitmen berkelanjutan dan kontribusinya paling rendah yaitu komitmen efektif. (4) Ada pengaruh kepemimpinan kepala sekolah, budaya sekolah, dan komitmen kerja secara bersama-sama terhadap disiplin guru sebesar 65,8%, dengan kontribusi tertinggi dari variabel kepemimpinan kepala sekolah dan kontribusi terendah dari variabel komitmen kerja guru. Berdasarkan hasil penelitian maka direkomendasikan, (1) Guru agar memiliki komitmen terhadap tanggungjawab tugasnya secara disiplin. (2) Kepala sekolah agar melibatkan guru dalam menyusun perencanaan kegiatan sekolah. (3) Dinas Pendidikan untuk memberikan arahan kepada kepala sekolah agar memberikan bimbingan kepada semua guru untuk mentaati peraturan jam kerja ASN.Kata kunci: kepemimpinan kepala sekolah, budaya sekolah, komitmen kerja, disiplin guru.
PENGARUH MOTIVASI KERJA GURU, BUDAYA SEKOLAH, DAN KETERAMPILAN MANAJER TERHADAP MUTU SMK NEGERI DI KABUPATEN JEPARA
Authors: Aryanti Hestining , Yuliejantiningsih Yovitha , Miyono Noor
Published: November 2023

AbstrakMutu sekolah tidak hanya dilihat dari nilai dalam rapor mutu sekolah, tetapi juga dapat dilihat dari proses pendidikan di dalamnya sehingga mampu menghasilkan siswa yang kompeten serta lulusan yang dapat terserap di dunia kerja. Mutu sekolah dapat dipengaruhi beberapa faktor yaitu motivasi kerja guru, budaya sekolah, dan keterampilan manajer. Tujuan penelitian ini adalah untuk mengetahui pengaruh motivasi kerja guru, budaya sekolah, dan keterampilan manajer terdahadap mutu Sekolah Menengah Kejuruan (SMK) negeri di Kabupaten Jepara. Populasi dalam penelitian ini adalah guru mata pelajaran produktif SMK negeri di Kabupaten Jepara sebanyak 230 orang, dengan jumlah sampel 139 orang. Teknik sampling menggunakan proporsional random sampling dengan pendekatan kuantitatif dan jenis penelitian korelasi. Metode pengumpulan data menggunakan kuesioner. Analisis data mengunakan analisis deskriptif, uji persyaratan dan uji hipotesis dengan analisis regresi linier sederhana dan regresi ganda. Hasil penelitian ini menunjukkan bahwa terdapat pengaruh motivasi kerja guru, budaya sekolah, keterampilan manajer terhadap mutu SMK negeri di kabupaten Jepara baik secara terpisah maupun bersama-sama.Kata Kunci: motivasi kerja guru, budaya sekolah, keterampilan manajer, mutu sekolah.
MANAJEMEN PROMOSI PENERIMAAN PESERTA DIDIK BARU DI SMK NEGERI 1 KANDEMAN BATANG
Authors: Farozi Farozi , Abdullah Ghufron , Soedjono Soedjono
Published: November 2023

ABSTRAK                                                         Penelitian ini dilatarbelakangi oleh persaingan antar sekolah dalam mencari siswa baru. Hal ini menuntut sekolah untuk menemukan dan menerapkan formula jitu promosi efektif sekolah. SMK Negeri 1 Kandeman Batang adalah salah satu sekolah yang memiliki formula tersebut. Data PPDB tiga tahun terahir di SMK Negeri 1 Kandeman yaitu 2019-2022 pendaftar selalu meningkat dari sebanyak 1003 menjadi 1230 dan 1200 sedangkan kuota hanya 500. Dari data tersebut terlihat jelas, jika SMK Negeri 1 Kandeman merupakan sekolah dengan jumlah peminat yang tinggi. Terlebih, diantara pendaftar tersebut, baik yang diterima ataupun tidak, merupakan calon siswa dari luar daerah yang memang sengaja berniat bersekolah di SMK Negeri 1 Kandeman.Penelitian ini merupakan penelitian diskriptif kualitatif dengan pendekatan case study. Penelitian dilakukan di SMK Negeri 1 Kandeman dengan melibatkan ketua PPDB, ketua tim promosi sekolah, ketua BKK, kepala sekolah, guru, dan siswa. Penelitan ini dimulai pada bulan Agustus 2022 hingga Januari 2022. Hasil penelitian menunjukkan bahwa implementasi promosi di SMK Negeri 1 Kandeman dilakukan dengan mix metode, yaitu metode konvensional humanis dan berbasis IT. Ada empat metode menejemen promosi yang digunakan di SMK Negeri 1 Kandeman, yaitu: Manajemen periklanan, manajemen personal selling, manajemen publishitas, dan manajemen promosi penjualan.Walaupun hasil dari penelitian ini menunjukkan efektifitas strategi promosi yang efektif, tetapi kami menyarankan jika para praktisi untuk mengkaji, mengembangkan, dan mensesuaikan potensi-potensi yang ada di daerah masing-masing.Kata kunci: Manajemen, Promosi, Penerimaan Peserta Didik Baru, SMK
PENGARUH KOMPETENSI MANAJERIAL KEPALA SEKOLAH, BUDAYA SEKOLAH DAN KINERJA GURU TERHADAP MUTU PENDIDIKAN DI MA SWASTA SE-KABUPATEN BATANG
Authors: Yusuf Achmad , Murniati Ngurah Ayu Nyoman , Prayito Muhammad
Published: November 2023

ABSTRAKPenelitian ini bertujuan untuk mengetahui (1) pengaruh kompetensi manajerial kepala sekolah terhadap mutu pendidikan; (2) Pengaruh budaya sekolah terhadap mutu pendidikan dan (3) Pengaruh kinerja guru terhadap mutu penididkan (4) pengaruh kompetensi manajerial kepala sekolah, budaya sekolah dan kinerja guru secara simultan terhadap mutu pendidikan. Metode yang digunakan dalam penelitian ini adalah metode kuantitatif. Penelitian ini merupakan penelitian desain ex-post facto yang dilaksanakan di MA Swasta se-kab Batang yang jumlah sampel sebanyak 171 guru. teknik pengumpulan data yaitu metode angket dan dokumentasi. Adapun teknik analisis data yang digunakan dalam penelitian ini adalah analisis uji normalitas, , dan uji homogenitas hasil penelitian yang mencakup analisi deskriptif dan regresi linear berganda.Hasil penelitian dari uji statistic t diperoleh nilai signifikan dari kompetensi manajerial kepala sekolah  terhadap mutu Pendidikan  adalah 0,033 artinya nilai tersebut lebih kecil dari 5 % sehingga kompetensi manajerial kepala sekolah  berpengaruh terhadap mutu Pendidikan d di MA Se-Kabupaten Batang, Sedangkan untuk budaya sekolah secara parsial juga tidak berpengaruh terhadap mutu pembelajaran, hal ini dibuktikan dengan uji statistic t yang memperoleh hasil 0,627, artinya lebih kecil dari 5%. Sedangkan untuk kinerja guru diperoleh hasil 0,022 artinya nilai tersebut lebih kecil dari 5 %. Sedangkan   Secara simultan penguasaan teknologi dan budaya sekolah juga berpengaruh terhadap mutu pembelajaran karen ahasil uji F diperoleh nilai signifikan sebesar 0,000. Kata Kunci:    Kompetensi Manajerial Kepala Sekolah, Budaya Sekolah, Kinerja Guru dan Mutu Pendidikan.
PENGARUH IKLIM ORGANISASI SEKOLAH DAN BUDAYA KERJA TERHADAP MOTIVASI KERJA GURU SEKOLAH MENENGAH PERTAMA NEGERI
Authors: Roviana Siti , Haryati Titik , Yuliejantiningsih Yovitha
Published: November 2023

ABSTRAKPermasalahan dalam penelitian ini adalah: (1) Adakah pengaruh iklim organisasi sekolah terhadap motivasi kerja guru SMP Negeri di Kecamatan Reban, Kabupaten Batang?, (2) Adakah pengaruh budaya kerja terhadap motivasi kerja guru SMP Negeri di Kecamatan Reban, Kabupaten Batang?, (3) Adakah pengaruh iklim organisasi sekolah dan budaya kerja secara bersama terhadap motivasi kerja guru SMP Negeri di Kecamatan Reban, Kabupaten Batang?. Tujuan dari penelitian ini adalah (1) untuk mengetahui ada tidaknya pengaruh iklim organisasi sekolah terhadap motivasi kerja guru SMP Negeri di Kecamatan Reban Kabupaten Batang, (2) untuk mengetahui ada tidaknya pengaruh budaya kerja  terhadap motivasi kerja guru SMP Negeri di Kecamatan Reban Kabupaten Batang, (3) untuk mengetahui ada tidaknya pengaruh iklim organisasi sekolah dan budaya kerja terhadap motivasi kerja guru SMP Negeri di Kecamatan Reban Kabupaten Batang.Populasi dalam penelitian ini adalah seluruh  guru SMP Negeri  baik ASN maupun Non ASN di Kecamatan Reban Kabupaten Batang yang  berjumlah 138 orang, diperoleh sampel sebanyak 103 orang dengan menggunakan teknik Proportional Random Sampling. Metode pengumpulan data yang digunakan adalah metode kuisioner. Analisis data yang digunakan adalah analisis statistik deskriptif, uji prasyarat dan  uji regresi linier berganda untuk mengetahui pengaruh iklim organisasi sekolah dan budaya kerja secara bersama-sama terhadap motivasi kerja guru. Untuk menganalisis data menggunakan fasilitas program SPSS 24.0.Dari hasil penelitian dapat diketahui bahwa rata-rata perolehan skor iklim organisasi sekolah 117,65 termasuk kategori cukup baik, rata-rata perolehan skor budaya kerja adalah 124,80 termasuk kategori cukup baik dan rata-rata perolehan skor motivasi kerja guru 126,13 termasuk kategori tinggi. Hasil uji prasyarat dari data penelitian diperoleh data berdistribusi normal, linier, dan tidak terjadi multikolinier. Dari uji hipotesis ditemukan terdapat pengaruh positif iklim organisasi sekolah terhadap motivasi kerja guru yang dinyatakan dengan persamaan Y = 53,363 + 0,618X1, kekuatan korelasi sebesar 0,870 dengan kontribusi sebesar 0,757 atau 75,7%. Terdapat pengaruh positif budaya kerja terhadap motivasi kerja guru yang dinyatakan dengan persamaan Y = 38,836 + 0,699X2, kekuatan korelasi sebesar 0,907 dengan kontribusi sebesar 0,823 atau 82,3%. Terdapat pengaruh positif iklim organisasi sekolah dan budaya kerja secara bersama-sama terhadap motivasi kerja guru yang dinyatakan dengan persamaan Y = 38,579 + 0,244X1 + 0,471X2, kekuatan korelasi sebesar 0,924 dengan kontribusi sebesar 0,854 atau 85,4%. Berdasarkan hasil penelitian ini, maka disarankan kepada kepala sekolah untuk mendorong terciptanya iklim organisasi yang sehat dan budaya kerja yang baik agar  iklim organisasi sekolah dan budaya kerja secara bersama-sama berpengaruh terhadap motivasi kerja guru. Kata Kunci : iklim organisasi sekolah, budaya kerja, motivasi kerja guru
New Complexes of Isoniazid Derivative with 3d Metals: Synthesis, Structure and Molecular Docking
Authors: Ahmed M. A. , Shtyrlin V. G. , Gubaidullin A. T. , Bukharov M. S. , Serov N. Yu. , Burilov V. A. , Ermolaev A. V. , Fatykhova A. M.
Published: November 2023

This article reports the results of our study aimed at synthesizing and describing the structure and properties of new transition metal complexes with potential anti-tuberculosis and other related activities. For the first time, five bis-complexes of the ligand N’-(1-(6-methylpyridine-2-yl)ethylidene)isonicotinohydrazide (LH) with ions of five 3d metals (Cu(II), Mn(II), Co(II), Ni(II), and Zn(II)) were synthesized. The structures of all synthesized complexes in crystalline form were identified by X-ray diffraction (XRD) analysis. The resulting compounds were characterized by NMR, mass spectrometry, and electron spectroscopy. DFT/PCM calculations were performed on the structures of the five ML(OH) hydroxocomplexes formed during the hydrolysis of ML2 complexes in an aqueous medium within the physiological pH range. The binding energies of the ML(OH) complexes with the biotarget, the InhA protein of the Mycobacterium tuberculosis strain, were determined by molecular docking. The data obtained suggest that the studied complexes have high biological activity and warrant further biomedical research.
Atık Karbon Keçenin Pirol ile Polimerizasyonu ve Katot Olarak Kullanılabilirliği
Authors: Sezer Mesut , İşgören Melike , Veli Sevil , Dimoglo Anatoli
Published: November 2023

Elektrokimyasal prosesler, atıksudaki karışık kirletici yükünü tek basamakta arıtabilmeleri ve kısa sürede yüksek giderim verimi sağlamaları nedeniyle yaygın olarak kullanılmaktadır. Son yıllarda bu arıtım yön-temleri ile ilgili en hızlı teknolojik gelişmeler yenilikçi elektrot üretimi alanında olup, birçok araştırmacı anot ve katot aktivitesini arttırmayı amaçlayan çalışmalar yapmaktadır. Bu çalışmaların bir diğer hedefi ise elektrot üretiminde en çok kullanılan ve yerkabuğundaki oranları her geçen gün azalan metallere alternatif olabilecek; elde edilmesi kolay, ucuz ve sürdürülebilir hammaddelerden elektrot eldesidir. Çalışmamızda kimyasal oksidatif polimerizasyon yöntemi kullanılarak atık karbon keçe (KK) üzerinde pirol monomeri-nin FeCl3.6H2O oksidantı ile polimerizyonu yapılmıştır. Polimerizasyon sonucunda polipirol kaplı karbon keçe (KK/PPy) elde edilmiştir. KK/PPy ve KK’nın elektrot olarak etkinliği elektrooksidasyon prosesinde boya giderimi üzerinden araştırılmıştır. Ayrıca pirol konsantrasyonu (0.05-1 M), oksidant konsantrasyonu (0.05-0.5 M) ve sıcaklığın (5-600C) katodun kütlesel artışı ve direnç azalışı üzerine etkisi incelenmiştir. En yüksek direnç azalışını sağlayan polimerizasyon koşulları 0.2 M pirol konsantrasyonu, 0.3 M FeCl3.6H2O konsantrasyonu ve sıcaklık 50C olarak bulunmuştur. Optimum koşullarda üretilen KK/PPy ve işlem gör-memiş KK elektrooksidasyon prosesinde katot olarak kullanılarak aktiviteleri birbiri ile karşılaştırılmış ve boya gideriminde KK/PPy’nin daha etkili olduğu görülmüştür. Ayrıca tekstil atığı olarak ortaya çıkan atık karbon keçeden elektrot malzemesi üretilmesi sürdürülebilir bir yötem olarak çevrenin ve doğal kaynakla-rın korunması ilkesine hizmet eden yenilikçi bir yaklaşımdır.
Nevşehir İli Hava Kalitesinin Mevsimsel ve Senelik Değerlendirilmesi
Authors: YAKUT Şennur Merve
Published: November 2023

Bu çalışmada Türkiye’nin İç Anadolu Bölgesinde bulunan turizm faaliyetleri yüksek bir il olan Nevşehir ilinin hava kalitesi incelenmiştir. Son üç yıla ait veriler (2020,2021,2022) mevsimlik ve yıllık olarak değerlendirilmiştir. Bu veriler üç adet parametreye göre: Partikül madde, sülfür dioksit ve karbon monoksit (PM10, SO2 ve CO) ele alınmıştır. Nüfus artışı, taşıt trafiğinde artış, meteorolojik olaylar, endüstrileşme hava kirliliğini etkileyen oldukça önemli faktörlerdir. Bu faktörler Nevşehir ilinde de özellikle kış aylarında hava kirletici parametrelerin artışına sebep olmaktadır. Nevşehir ilinde kışların uzun geçmesiyle birlikte hava kirleticilerin etkinliğini daha uzun süre sürdürmesine yol açmaktadır. Yıllara göre bakıldığında ise CO parametresinde azalma gözlemlenmiştir. Bunun yanı sıra, PM10’da ise az miktarda bir artış söz konusudur. Bu kapsamda, dünyanın en çok turist çeken bölgelerinden biri olan Kapadokya bölgesi içerisindeki Nevşehir ilinin hava kalitesinin değerlendirilmesi amaçlanmıştır. Özetle, dünyanın ve Türkiye’nin farklı noktalarından turist ziyaretine uğrayan Nevşehir iline ait veriler incelendiğinde genel olarak hava kalitesi iyi olarak değerlendirilebilmektedir.