bluuebunny/crossref_metadata_2025 huggingface dataset:
Metabolic regulation in the lactating mammary gland: a lipid synthesizing machine
Authors: Rudolph Michael C. , McManaman James L. , Phang TzuLip , Russell Tanya , Kominsky Douglas J. , Serkova Natalie J. , Stein Torsten , Anderson Steven M. , Neville Margaret C.
Published: November 2006

The mammary gland of the lactating mouse synthesizes and secretes milk lipid equivalent to its entire body weight in a single 20-day lactation cycle, making it one of the most active lipid synthetic organs known. We test the hypothesis that multiple control points and potential regulatory mechanisms regulate milk lipid synthesis at the level of gene expression. The mammary transcriptome of 130 genes involved in glucose metabolism was examined at late pregnancy and early lactation, utilizing data obtained from microarray analysis of mammary glands from quadruplicate FVB mice at pregnancy day 17 and lactation day 2. To correlate changes with physiological parameters, the metabolome obtained from magnetic resonance spectroscopy of flash-frozen glands at day 17 of pregnancy was compared with that at day 2 of lactation. A significant increase in carbohydrates (glucose, lactose, sialic acid) and amino acids (alanine, aspartate, arginine, glutamate) with a moderate increase in important osmolytes ( myo-inositol, betaine, choline derivatives) were observed in the lactating gland. In addition, diets containing 8% or 40% lipid were fed from lactation days 5–10 and mammary glands and livers of triplicate FVB mice prepared for microarray analysis. The results show that substantial regulation of lipid synthesis occurs at the level of mRNA expression and that some of the regulation points differ substantially from the liver. They also implicate the transcription factor SREBP-1c in regulation of part of the pathway.
Heightened Functional Neural Activation to Psychological Stress Covaries With Exaggerated Blood Pressure Reactivity
Authors: Gianaros Peter J. , Jennings J. Richard , Sheu Lei K. , Derbyshire Stuart W.G. , Matthews Karen A.
Published: November 2006

Individuals who show exaggerated blood pressure reactions to psychological stressors are at increased risk for hypertension, atherosclerosis, and stroke. We tested whether individuals who show exaggerated stressor-induced blood pressure reactivity also show heightened stressor-induced neural activation in brain areas involved in controlling the cardiovascular system. In a functional MRI study, 46 postmenopausal women (mean age: 68.04; SD: 1.35 years) performed a standardized Stroop color-word interference task that served as a stressor to increase blood pressure. Across individuals, a larger task-induced rise in blood pressure covaried with heightened and correlated patterns of activation in brain areas implicated previously in stress-related cardiovascular control: the perigenual and posterior cingulate cortex, bilateral prefrontal cortex, anterior insula, and cerebellum. Entered as a set in hierarchical regression analyses, activation values in these brain areas uniquely predicted the magnitude of task-induced changes in systolic (Δ
R
2
=0.54;
P
<0.001) and diastolic (Δ
R
2
=0.27;
P
<0.05) blood pressure after statistical control for task accuracy and subjective reports of task stress. Heightened stressor-induced activation of cingulate, prefrontal, insular, and cerebellar brain areas may represent a functional neural phenotype that characterizes individuals who are prone to show exaggerated cardiovascular reactivity.
Engaging the Animal in the Moving Image
Authors: Porter Pete
Published: November 2006

Human engagement with nonhuman animals in motion pictures is a complex process that anthropomorphism and identification misconstrue. A superior model comes from cognitive theories of how spectators engage characters, particularly Smith (1995), who suggests modifications to account for the nuances of spectator engagement with nonhuman animal characters. The central components of this amended model include the person schema, the three types of cues that films use to activate the person schema, and what Smith calls the "Structure of Sympathy." Such a model enables us to understand better the role that moving image representations of nonhuman animals play in human-animal relationships.
Hawksbill turtle (Eretmochelys imbricata Linnaeus 1766) and green turtle (Chelonia mydas Linnaeus 1754) nesting activity (2002-2004) at El Cuyo beach, Mexico
Authors: Xavier Raquel , Barata Andre , Cortez Leopoldo Palomo , Queiroz Nuno , Cuevas Eduardo
Published: November 2006

The Yucatan Peninsula nesting hawksbill turtles' population (Eretmochelys
imbricata Linnaeus 1766) is the biggest in the Caribbean and fourth in the
world; within the Ría Lagartos Biosphere Reserve, at El Cuyo beach both
hawksbill and green turtle (Chelonia mydas Linnaeus 1754) nest. In the
present study, the nesting trend and reproductive output of both species
during three consecutive nesting seasons (2002-2004) was evaluated. Night
patrols from mid April to September allowed the collection of data on number
of nests, nest location and size of females. The number of hawksbill and
green turtles' nests decreased along these seasons. No differences were
found in mean length of female turtles of both species between nesting
seasons. Both species showed high nest site fidelity with average distance
between nests of 3 km for Hawksbill and 1.8 km for Green turtles. The
regression analysis between size and fecundity was significant (p < 0.05)
for both species. The spatial variation of laid nests was also analyzed
revealing that both species nested mainly on the dune zone. Predation has
risen on El Cuyo beach, affecting mostly hawksbills nests. Hurricane Ivan
destroyed the majority of green turtles nests in 2004.
Foraging ecology of the Tokay gecko, Gekko gecko in a residential area in Thailand
Authors: Aowphol Anchalee , Thirakhupt Kumthorn , Nabhitabhata Jarujin , Voris Harold K.
Published: November 2006

The foraging behavior of Gekko gecko was observed at the visitor complex of
the Khao Khiao Open Zoo at the Khao Khiao-Khao Chomphu Wildlife Sanctuary in
Chon Buri Province, Thailand. Foraging parameters of G. gecko (foraging
period, time spent moving, foraging attempts, foraging success, prey size
consumed, and foraging distance) did not vary significantly between males,
females, and juveniles. Individuals foraged between 18:01 and 09:00 hrs.
Peak emergence time was between 18:01 and 20:00 hrs. Peak retreat time was
between 04:01 and 07:00 hrs. Major food items included insects of the orders
Lepidoptera, Orthoptera, and Coleoptera. Prey sizes of males, females, and
juveniles were not significantly different, indicating no prey size
selection. This may have been due to low insect availability in the habitat.
Gekko gecko tended to be a sit-and-wait forager spending most of the time
waiting for active prey. However, it sometimes foraged more actively when
insect abundance was relatively high. Foraging behavior of males tended to
be more variable than females and juveniles. In addition, variation in
foraging parameters among individuals was noted. Foraging strategies of G.
gecko observed in this study are interpreted in the context of optimal
foraging theory.
On the identity of two Paralongidorus species (Nematoda: Longidoridae) described from Montenegro and Serbia
Authors: Roca Francesco
Published: November 2006

Specimens collected from various localities in Montenegro and Serbia were previously described as Paralongidorus milanis and P. serbicus, respectively. However, SEM studies of the amphidial apertures of paratype females have shown that the species were originally placed in the wrong genus. Both species have pore-like amphidial apertures, not slit-like as in the genus Paralongidorus and they are therefore transferred to the genus Longidorus. Longidorus milanis n. comb. is regarded as a valid species whereas L. serbicus n. comb. is morphologically identical to L. moesicus, small morphometric differences being attributed to intraspecific variations. As a result, L. serbicus n. comb. is proposed as a junior synonym of L. moesicus
Liberal Islam and 'Islam and Human Rights': A Sceptic's View
Authors: Chase Anthony
Published: November 2006

Liberal Islam has become increasingly prominent in academic discourse with its argument that Islam is the necessary foundation to human rights in the Muslim world. This article argues that this theoretical premise is misguided. Instead of whether or not the rights regime makes sense given political, economic, and social context in Muslim-majority states, in a liberal Islam paradigm the question becomes whether or not there are convincing doctrinal arguments regarding the place of human rights in Islamic law. This accepts, in essence, the need for literalist religious justifications for human rights, making an argument for rights a dispute over religious doctrine: a dispute that takes place on an elite, juristic field on which reformers have little claim to institutional authority, human rights scant normative power, and that is disconnected from everyday political and normative realities. More dangerously, it risks reifying the notion that Islam monopolizes the Muslim public sphere, rather than leaving space for normative diversity. Human rights foundations must be based in the theoretical premise that political change flows out of inherently pluralistic normative environments, and that this is as true in the Muslim world as it is elsewhere.
Effect of TiO2 Particle Size on the Performance of Viologen-Anchored TiO2 Electrochromic Device
Authors: Kim Yong Joo , Jeong Hyun Ki , Seo Jung Kyu , Chai Seung Yong , Kim Young Seok , Lim Goo Il , Cho Min Ho , Lee Ik-Mo , Choi Young S. , Lee Wan In
Published: November 2006

The effect of TiO2 particle size on the performance of the electrochromic device (ECD) has been investigated in this work by applying the TiO2 nanoparticles in 7, 15, and 30 nm sizes. The phosphonated viologen, bis(2-phosphonoethyl)-4,4′-bipyridinium dibromide,
was anchored on the TiO2 surfaces for the construction of ECD. The ECD derived from 7 nm-sized TiO2 demonstrated the highest contrast ratio with high optical transparency, whereas it showed the slowest switching response. The enhancement of coloration efficiency with
decrease of TiO2 particle size is due to the increased amount of the anchored viologen on TiO2 electrode. On the other hand, the relatively slower switching response would be caused by the difficulty of diffusion for the electrolytes and counter-ions through the small
pores of the nanocrystalline TiO2 electrode derived from 7 nm-sized nanoparticles.
Patients as Partners in a Health Research Agenda Setting
Authors: Abma Tineke A.
Published: November 2006

This article deals with the participation of patients in setting the agenda of health research that potentially directly affects their lives. The focus is on the communication problems encountered between lay people and medical professionals in developing a joint research agenda. The author argues that a participatory methodology can address these problems and thereby give patients “a say” in the types of health research that have the greatest chance of affecting them personally. The article uses a case example of people with spinal cord injuries participating in research to support the importance and value of patient participation. The case example also helps to rethink appropriate methodologies or at least to modify existing approaches by paying more attention to required social conditions, diversity, and the life world of patients to foster meaningful participation.
An Exploration of Nursing Home Organizational Processes
Authors: Forbes-Thompson Sarah , Gajewski Byron , Scott-Cawiezell Jill , Dunton Nancy
Published: November 2006

The purpose of this study is to explore the relationship between nursing home staffs' perceptions of organizational processes (communication, teamwork, and leadership) with characteristics (turnover, tenure, and educational preparation) of the nursing home administrator (NHA) and director of nursing (DON). NHAs and DONs rate communication, teamwork, and leadership significantly higher than direct care staff do (registered nurses, licensed practical nurses, certified nurse aides [CNAs]). CNAs have the lowest ratings of communication and teamwork. Turnover of the NHA and DON is significantly and negatively associated with communication and teamwork. Two thirds of DONs surveyed hold less than a baccalaureate degree; this does not influence staffs' ratings of communication, teamwork, and leadership. Findings from this study highlight the need to explore differences in perceptions between administrative and direct care staff and how these may or may not influence staff development and quality improvement activities in nursing homes.
Family Structure and Mothers’ Caregiving of Children With Cystic Fibrosis
Authors: Gayer Debra , Ganong Lawrence
Published: November 2006

The purpose of this investigation is to examine differences in the experiences of mothers of children with cystic fibrosis who are in diverse family structures (first-marriage families, stepfamily households, single-parent households). In particular, mothers’ perceptions of children’s health, adherence to prescribed treatments, and help received from others were compared and predictors of treatment adherence were examined. Children’s health and adherence to treatment regimens were not related to family structure. Mothers had the major responsibility for seeing that cystic fibrosis treatments were followed, regardless of family structure. Single mothers received less help than married and repartnered mothers. Married fathers helped with treatments more than nonresidential divorced fathers and stepfathers. Implications for nursing practice and suggestions for future research are offered.
Integrating Process with Outcome Data in a Randomized Controlled Trial of Sex Education
Authors: Strange Vicki , Allen Elizabeth , Oakley Ann , Bonell Chris , Johnson Anne , Stephenson Judith , The Ripple Study Team
Published: November 2006

Integration of process with outcome evaluations has been recommended as a way of addressing some of the criticisms of Randomized Controlled Trials (RCTs) for evaluating social interventions. This is the second of two articles (the first was published in issue 10(4) of this journal) discussing the design, implementation and analysis of a process evaluation as an integral part of the RIPPLE (Randomized Intervention of Pupil Peer-Led sex Education) Study. The methods for integrating process and outcome data are outlined and findings are presented to illustrate how integration of process and outcome data enabled exploration of: 1) variation between schools in the extent and quality of the intervention implemented, and any impact of this on outcomes; 2) the processes by which the intervention might affect outcomes; and 3) the extent to which different subgroups of students or schools may have responded differently to the intervention. The article concludes with a discussion of the methodological issues arising from this attempt at integrating process and outcome evaluations within the design of an RCT.
Hypothalamic Neural Circuits Regulating Maternal Responsiveness Toward Infants
Authors: Numan Michael
Published: November 2006

A theoretical neural model is developed, along with supportive evidence, to explain how the medial preoptic area (MPOA) of the hypothalamus can regulate maternal responsiveness toward infant-related stimuli. It is proposed that efferents from a hormone-primed MPOA (a) depress a central aversion system (composed of neural circuits between the amygdala, medial hypothalamus, and midbrain) so that novel infant stimuli do not activate defensive or avoidance behavior and (b) excite the mesolimbic dopamine system so that active, voluntary maternal responses are promoted. The effects of oxytocin and maternal experience are included in the model, and the specificity of MPOA effects are discussed. The model may be relevant to the mechanisms through which other hypothalamic nuclei regulate other basic motivational states. In addition, aspects of the model may define a core neural circuitry for maternal behavior in mammals.
Instrumental Learning Within the Spinal Cord: Underlying Mechanisms and Implications for Recovery After Injury
Authors: Grau James W. , Crown Eric D. , Ferguson Adam R. , Washburn Stephanie N. , Hook Michelle A. , Miranda Rajesh C.
Published: November 2006

Using spinally transected rats, research has shown that neurons within the L4-S2 spinal cord are sensitive to response-outcome (instrumental) relations. This learning depends on a form of N-methyl-D-aspartate (NMDA)-mediated plasticity. Instrumental training enables subsequent learning, and this effect has been linked to the expression of brain-derived neurotrophic factor. Rats given uncontrollable stimulation later exhibit impaired instrumental learning, and this deficit lasts up to 48 hr. The induction of the deficit can be blocked by prior training with controllable shock, the concurrent presentation of a tonic stimulus that induces antinociception, or pretreatment with an NMDA or gamma-aminobutyric acid-A antagonist. The expression of the deficit depends on a kappa opioid. Uncontrollable stimulation enhances mechanical reactivity (allodynia), and treatments that induce allodynia (e.g., inflammation) inhibit learning. In intact animals, descending serotonergic neurons exert a protective effect that blocks the adverse consequences of uncontrollable stimulation. Uncontrollable, but not controllable, stimulation impairs the recovery of function after a contusion injury.
Desordre a courte distance dans les phases transitoires resultant de l'activation thermique des montmorillonites
Authors: Delmastro A. , Bachiorrini A. , Murat M.
Published: November 2006

Des phases transitoires ont été préparées par activation thermique de deux montmorillonites, l'une calcique et l'autre sodique, dans le domaine de température 650–950°C, puis étudiées par spectroscopie infrarouge. Le coefficient de désordre à courte distance, défini à partir de l'élargissement et l'intensité de certaines bandes caracteristiques, présente ses valeurs maximales avec les phases transitoires obtenues à 800°C et 820–850°C respectivement pour la couche de silice et la couche d'alumine. Ce résultat a pu être corrélé à plusieurs données expérimentales concernant la cinétique de dissolution de ces phases transitoires dans l'acide fluorhydrique dilué ou dans des solutions saturées d'hydroxyde de calcium. En outre, l'accroissement particulièrement marqué du désordre à courte distance mis en évidence au niveau de la transition V→IV de la coordinance de l'aluminium, confirme l'hypothèses émise antérieurement par d'autres auteurs pour expliquer le troisième effet endothermique de faible intensité observé sur les courbes ATD des montmorillonites entre 800° et 900°C.
Mössbauer and chemical investigations of mudrocks
Authors: Davey R. , Curtis C. D.
Published: November 2006

The oxidation state and mineralogical distribution of Fe in two different shale sequences have been studied by Mössbauer spectroscopy and chemical methods. Kimmeridge Clay Formation sediments proved to be richer in total Fe than Gulf Coast shales. In such sediments, Fe may be present in clay minerals (Fe(II) in chlorite, Fe(III) in illite and illite/smectite), pyrite, and ferroan carbonates (siderite, dolomite and ankerite). Pyrite accounts for a much greater proportion of the total Fe in the Kimmeridge Clay samples in which it is difficult to reconcile chemical data with Mössbauer data. There is major doublet overlap of Fe(III) in silicates with Fe(II) in pyrite and spectra cannot be satisfactorily deconvoluted. This would appear to be a fundamental limitation for simple applications. In the pyrite-poor Gulf Coast material, however, chemical and spectroscopic evaluations of overall valence state are much more consistent. Confidence in both determinative techniques is generated, and useful information documenting progressive reduction and redistribution of Fe with burial is obtained.
The effect of temperature on the swelling of montmorillonite
Authors: Zhang F. , Zhang Z. Z. , Low P. F. , Roth C. B.
Published: November 2006

The effect of temperature on the swelling of clay was studied by determining (1) the relation between the interlayer spacing, λ, and the swelling pressure,Π, at different values of the temperature, T, using the method of Viani et al. (1983) as modified by Wu et al. (1989); (2) the relation between λ and T at different values of Π; and (3) the relationship between Π and mw/mc, the mass ratio of water to clay, at different values of T using the method of Low (1980). The results showed that λ was essentially independent of T but that mw/mc decreased slightly with T at any value of Π. Such results are not consistent with electric double-layer theory. Therefore, it was concluded that the decrease in mw/mc with increasing T was due primarily to the thermal breakdown and consequent loss of water from the larger pores outside of the interlayer region.
Pressure Induced Disorder in Kaolinite
Authors: La Iglesia A.
Published: November 2006

Changes caused by pressures between 0 and 20 K bar on two samples of kaolinite have been studied. Increased pressure causes the samples to lose crystallinity, shown by a decrease in the Hinckley, Lietard and reference intensity ratio indices, as well as by the crystallite size measured from the 001 reflection. Results from DTA and solid state NMR show slight or no differences between the compressed and natural samples. Nonetheless, thermogravimetry reveals that the pressure treatment lowers the temperature at which dehydroxylation begins, but, unlike the grinding process, pressure does not alter the OH content of the samples. As a result of the increase in pressure, the IR spectra of the samples show a gradual increase in the intensity of the band at 1104 cm -1 with respect to 1112 cm -1. An increase in intensity can also be observed in the band at 936 cm ~ with respect to the band at 912 cm -1. Examination by electron microscopy reveals the existence of a large number of defects such as fractures, bends and deformations of the sheets, etc.; these are responsible for the decrease in crystallinity.
The Recognition of Amorphous Silica in Indurated Soil Profiles
Authors: Singh Balbir , Gilkes R. J.
Published: November 2006

Silica-indurated subsurface horizons of an in situ lateritic profile in semi-arid western Australia were investigated using a range of electron-optical and X-ray diffraction (XRD) techniques. These indurated materials were compared with underlying non-indurated pallid zone material. The secondary silica content of the indurated horizons, as determined by electron microprobe analysis, varied from 8 to 33%. Quantitative digital images for secondary silica, generated by mathematical manipulation of digital Si and AI-Kα: images, showed that kaolinite pseudomorphs after mica contained the lowest amounts of secondary silica, with the highest amounts being present in the inter-pseudomorph clay matrix. Variations in the amount of silica in the matrix are considered to reflect variations in the initial porosity of the clay matrix. Such variations may arise from differences in the Al/Si ratio of parent minerals. Transmission electron microscopy (TEM) showed that amorphous silica adhered to the (001) face of kaolinite crystals. The secondary silica could not be detected by either standard or differential XRD procedures.
Determination of the Cation Exchange Capacity of Clays by Surface Tension Measurements
Authors: Burrafato G. , Miano F.
Published: November 2006

The cation exchange capacity (CEC) of clay minerals has been determined by titration of aqueous suspension of clays with hexadecylpyridinium chloride, monitored using surface tension measurements. In order to make the method suitable for an accurate analysis of the CEC of the clays in drilling fluids or in soils, some parameters affecting the CEC determination (e.g. the presence of carboxymethylcellulose, mixing time and measurement device) have been investigated.
A validated gene expression model of high-risk multiple myeloma is defined by deregulated expression of genes mapping to chromosome 1
Authors: Shaughnessy John D. , Zhan Fenghuang , Burington Bart E. , Huang Yongsheng , Colla Simona , Hanamura Ichiro , Stewart James P. , Kordsmeier Bob , Randolph Christopher , Williams David R. , Xiao Yan , Xu Hongwei , Epstein Joshua , Anaissie Elias , Krishna Somashekar G. , Cottler-Fox Michele , Hollmig Klaus , Mohiuddin Abid , Pineda-Roman Mauricio , Tricot Guido , van Rhee Frits , Sawyer Jeffrey , Alsayed Yazan , Walker Ronald , Zangari Maurizio , Crowley John , Barlogie Bart
Published: November 2006

To molecularly define high-risk disease, we performed microarray analysis on tumor cells from 532 newly diagnosed patients with multiple myeloma (MM) treated on 2 separate protocols. Using log-rank tests of expression quartiles, 70 genes, 30% mapping to chromosome 1 (P < .001), were linked to early disease-related death. Importantly, most up-regulated genes mapped to chromosome 1q, and down-regulated genes mapped to chromosome 1p. The ratio of mean expression levels of up-regulated to down-regulated genes defined a high-risk score present in 13% of patients with shorter durations of complete remission, event-free survival, and overall survival (training set: hazard ratio [HR], 5.16; P < .001; test cohort: HR, 4.75; P < .001). The high-risk score also was an independent predictor of outcome endpoints in multivariate analysis (P < .001) that included the International Staging System and high-risk translocations. In a comparison of paired baseline and relapse samples, the high-risk score frequency rose to 76% at relapse and predicted short postrelapse survival (P < .05). Multivariate discriminant analysis revealed that a 17-gene subset could predict outcome as well as the 70-gene model. Our data suggest that altered transcriptional regulation of genes mapping to chromosome 1 may contribute to disease progression, and that expression profiling can be used to identify high-risk disease and guide therapeutic interventions.
4SALE – A tool for synchronous RNA sequence and secondary structure alignment and editing
Authors: Seibel Philipp N , Müller Tobias , Dandekar Thomas , Schultz Jörg , Wolf Matthias
Published: November 2006

Background

In sequence analysis the multiple alignment builds the fundament of all proceeding analyses. Errors in an alignment could strongly influence all succeeding analyses and therefore could lead to wrong predictions. Hand-crafted and hand-improved alignments are necessary and meanwhile good common practice. For RNA sequences often the primary sequence as well as a secondary structure consensus is well known, e.g., the cloverleaf structure of the t-RNA. Recently, some alignment editors are proposed that are able to include and model both kinds of information. However, with the advent of a large amount of reliable RNA sequences together with their solved secondary structures (available from e.g. the ITS2 Database), we are faced with the problem to handle sequences and their associated secondary structures synchronously.

Results

4SALE fills this gap. The application allows a fast sequence and synchronous secondary structure alignment for large data sets and for the first time synchronous manual editing of aligned sequences and their secondary structures. This study describes an algorithm for the synchronous alignment of sequences and their associated secondary structures as well as the main features of 4SALE used for further analyses and editing. 4SALE builds an optimal and unique starting point for every RNA sequence and structure analysis.

Conclusion

4SALE, which provides an user-friendly and intuitive interface, is a comprehensive toolbox for RNA analysis based on sequence and secondary structure information. The program connects sequence and structure databases like the ITS2 Database to phylogeny programs as for example the CBCAnalyzer. 4SALE is written in JAVA and therefore platform independent. The software is freely available and distributed from the website at http://4sale.bioapps.biozentrum.uni-wuerzburg.de
Multiple endocrine neoplasia type 2
Authors: Marini Francesca , Falchetti Alberto , Del Monte Francesca , Carbonell Sala Silvia , Tognarini Isabella , Luzi Ettore , Brandi Maria Luisa
Published: November 2006

Multiple Endocrine Neoplasia Type 2 (MEN2) is a rare hereditary complex disorder characterized by the presence of medullary thyroid carcinoma (MTC), unilateral or bilateral pheochromocytoma (PHEO) and other hyperplasia and/or neoplasia of different endocrine tissues within a single patient. MEN2 has been reported in approximately 500 to 1000 families worldwide and the prevalence has been estimated at approximately 1:30,000. Two different forms, sporadic and familial, have been described for MEN2. Sporadic form is represented by a case with two of the principal MEN2-related endocrine tumors. The familial form, which is more frequent and with an autosomal pattern of inheritance, consists of a MEN2 case with at least one first degree relative showing one of the characteristic endocrine tumors. Familial medullary thyroid carcinoma (FMTC) is a subtype of MEN2 in which the affected individuals develop only medullary thyroid carcinoma, without other clinical manifestations of MEN2. Predisposition to MEN2 is caused by germline activating mutations of the c-RET proto-oncogene on chromosome 10q11.2. The RET gene encodes a single-pass transmembrane tyrosine kinase that is the receptor for glial-derived neurotrophic growth factors. The combination of clinical and genetic investigations, together with the improved understanding of the molecular and clinical genetics of the syndrome, helps the diagnosis and treatment of patients. Currently, DNA testing makes possible the early detection of asymptomatic gene carriers, allowing to identify and treat the neoplastic lesions at an earlier stage. In particular, the identification of a strong genotype-phenotype correlation in MEN2 syndrome may enable a more individualized treatment for the patients, improving their quality of life. At present, surgical treatment offers the only chance of cure and therefore, early clinical and genetic detection and prophylactic surgery in subjects at risk are the main therapeutic goal.
Severe brain injury ICU outcomes are associated with Cranial-Arterial Pressure Index and noninvasive Bispectral Index and transcranial oxygen saturation: a prospective, preliminary study
Authors: Dunham Michael , Ransom Kenneth J , McAuley Clyde E , Gruber Brian S , Mangalat Dev , Flowers Laurie L
Published: November 2006

Introduction

The purpose of this study was to determine if noninvasive transcranial oxygen saturation (StcO2) and Bispectral Index (BIS) correlate with severe traumatic brain injury intensive care unit (ICU) outcomes.

Methods

This is a prospective observational study. Values of intracranial pressure (ICP), mean arterial pressure (MAP), BIS, and StcO2 were recorded hourly for the first six, post-injury days in 18 patients with severe brain injury. Included in the analyses was the Cranial-Arterial Pressure (CAP) Index, which is ICP/(MAP - ICP).

Results

After 1,883 hours of data were analyzed, we found that StcO2 and BIS are associated with survival, good neurological outcome, ICP ≤20, cerebral perfusion pressure (CPP) ≥60, and CAP index ≤0.30 (p ≤ 0.001). Survival and good outcome are independently associated with BIS ≥60, StcO2 ≥70, and ICP ≤20 (p < 0.0001). BIS ≥60 or StcO2 ≥70 is associated with survival, good outcome, CPP ≥60, ICP ≤20, CAP index ≤0.30, and fewer ICP interventions (p < 0.0001). With BIS ≥60 or StcO2 ≥70, the rate of CPP ≥60 is 97.2% and the rate of ICP≤ 25 is 97.1%. An increased CAP index is associated with death, poor neurological outcome, and increased ICP interventions (p < 0.0001). With CAP index >0.25, MAP is not related to ICP (p = 0.16).

Conclusion

Numerous significant associations with ICU outcomes indicate that BIS and StcO2 are clinically relevant. The independent associations of BIS, StcO2, and ICP with outcomes suggest that noninvasive multi-modal monitoring may be beneficial. Future studies of patients with BIS ≥60 or StcO2 ≥70 will determine if select patients can be managed without ICP monitoring and whether marginal ICP can be observed. An increased CAP index is associated with poor outcome.
Characterizing an unstable mountain slope using shallow 2D and 3D seismic tomography
Authors: Heincke Bjoern , Maurer Hansruedi , Green Alan G. , Willenberg Heike , Spillmann Tom , Burlini Luigi
Published: November 2006

As transport routes and population centers in mountainous areas expand, risks associated with rockfalls and rockslides grow at an alarming rate. As a consequence, there is an urgent need to delineate mountain slopes susceptible to catastrophic collapse in a safe and noninvasive manner. For this purpose, we have developed a 3D tomographic seismic refraction technique and applied it to an unstable alpine mountain slope, a significant segment of which is moving at [Formula: see text] toward the adjacent valley floor. First arrivals recorded across an extensive region of the exposed gneissic rock mass have extraordinarily low apparent velocities at short [Formula: see text] to long [Formula: see text] shot-receiver offsets. Inversion of the first-arrival traveltimes produces a 3D tomogram that reveals the presence of a huge volume of very-low-quality rock with ultralow to very low P-wave velocities of [Formula: see text]. These values are astonishingly low compared to the average horizontal P-wave velocity of [Formula: see text] determined from laboratory analyses of intact rocks collected at the investigation site. The extremely low field velocities likely result from the ubiquitous presence of dry cracks, fracture zones, and faults on a wide variety of scales. They extend to more than [Formula: see text] depth over a [Formula: see text] area that encompasses the mobile segment of the mountain slope, which is transected by a number of actively opening fracture zones and faults, and a large part of the adjacent stationary slope. Although hazards related to the mobile segment have been recognized since the last major rockslides affected the mountain in 1991, those related to the adjacent low-quality stationary rock mass have not.
On bias and noise in passive seismic data from finite circular array data processed using SPAC methods
Authors: Asten Michael W.
Published: November 2006

The finite nature of typical small seismic arrays used in conjunction with spatial autocorrelation (SPAC) processing for observing the microtremor wavefield causes predictable perturbations of the SPAC spectrum when sources of seismic noise are confined to a restricted range of azimuths. Such perturbations are especially evident at higher frequencies where wavelengths are on the order of the array radius. The effects are readily modeled and show that the triangular array geometries commonly used for microtremor studies require azimuthal distributions of wave energy on the order of [Formula: see text] or greater to have a high probability of being free of such perturbations. The imaginary component of the SPAC spectrum, which is ideally zero for a sufficiently dense circular array and/or a sufficiently isotropic wavefield, is in practice often nonzero and provides three quality-control indicators: (1) an indication of insufficient spatial averaging, (2) an empirical measure of the level of statistical uncertainty in SPAC spectral estimates, and (3) an indication of departures from plane-wave stationarity of the seismic noise wavefield.
Seismic tomography studies of cover thickness and near-surface bedrock velocities
Authors: Bergman B. , Tryggvason A. , Juhlin C.
Published: November 2006

Reflection seismic imaging of the uppermost kilometer of crystalline bedrock is an important component in site surveys for locating potential storage sites for nuclear waste in Sweden. To obtain high-quality images, refraction statics are calculated using first-break traveltimes. These first-break picks may also be used to produce tomographic velocity images of the uppermost bedrock.

In an earlier study, we presented a method applicable to data sets where the vast majority of shots are located in the bedrock below the glacial deposits, or cover, typical for northern latitudes. A by-product of this method was an estimate of the cover thickness from the receiver static that was introduced to sharpen the image. We now present a modified version of this method that is applicable for sources located in or on the cover, the general situation for nuclear waste site surveys. This modified methodalso solves for 3D velocity structure and static correctionssimultaneously in the inversion process. The static corrections can then be used to estimate the cover thickness.

First, we test our tomography method on synthetic data withthe shot points in the bedrock below the cover. Next, we developa strategy for the case when the sources are within the cover. Themethod is then applied to field data from five crooked-line,high-resolution reflection seismic profiles ranging in lengthfrom 2 to [Formula: see text]. The crooked-line profiles make the study 2.5dimensional regarding bedrock velocities. The cover thicknessalong the profiles varies from 0 to [Formula: see text]. Estimated thickness ofthe cover agrees well with data from boreholes drilled near theprofiles. Low-velocity zones in the uppermost bedrock generallycorrelate with locations where reflections from the stackedsections project to the surface. Thus, the method is functional,both for imaging the uppermost bedrock velocities as well as for estimating the cover thickness.
Linear inverse Gaussian theory and geostatistics
Authors: Hansen Thomas Mejer , Journel Andre G. , Tarantola Albert , Mosegaard Klaus
Published: November 2006

Inverse problems in geophysics require the introduction of complex a priori information and are solved using computationally expensive Monte Carlo techniques (where large portions of the model space are explored). The geostatistical method allows for fast integration of complex a priori information in the form of covariance functions and training images. We combine geostatistical methods and inverse problem theory to generate realizations of the posterior probability density function of any Gaussian linear inverse problem, honoring a priori information in the form of a covariance function describing the spatial connectivity of the model space parameters. This is achieved using sequential Gaussian simulation, a well-known, noniterative geostatisticalmethod for generating samples of a Gaussian random field with a given covariance function.

This work is a contribution to both linear inverse problem theory and geostatistics. Our main result is an efficient method to generate realizations, actual solutions rather than the conventional least-squares-based approach, to any Gaussian linear inverse problem using a noniterative method. The sequential approach to solving linear and weakly nonlinear problems is computationally efficient compared with traditional least-squares-based inversion. The sequential approach also allows one to solve the inverse problem in only a small part of the model space while conditioned to all available data. From a geostatistical point of view, the method can be used to condition realizations of Gaussian random fields to the possibly noisy linear average observations of the model space.
Fourier reconstruction of marine-streamer data in four spatial coordinates
Authors: Zwartjes P. , Gisolf A.
Published: November 2006

Many methods exist for interpolation of seismic data in one and two spatial dimensions, but few can interpolate properly in three or four spatial dimensions. Marine multi-streamer data typically are sampled relatively well in the midpoint and absolute offset coordinates but not in the azimuth because the crossline shot coordinate is significantly under sampled. We approach the problem of interpolation of marine-streamer data in four spatial dimensions by splitting the problem into a 1D interpolation along the densely sampled streamers and a 3D Fourier reconstruction for the remaining spatial coordinates. In Fourier reconstruction, the Fourier coefficients that synthesize the nonuniformly sampled seismic data are estimated in a least-squares inversion. The method is computationally efficient, requires no subsurface information, and can handle uniform grids with missing data as well as nonuniform grids or random sampling.

The output grid of the 1D interpolation in the first step is arbitrary. When the output grid has uniform inline midpoints spacing, the 3D Fourier reconstruction in the second step is performed in the crossline midpoint, absolute offset, and azimuth coordinates. When the first step outputs to uniform absolute offset, the 3D Fourier reconstruction handles the crossline/inline midpoint and the azimuth coordinates. In both cases, the main innovation is the inclusion of the azimuthal coordinate in the Fourier reconstruction. The azimuth multiplicity must be increased for the method to be successful, which means that overlap shooting is required. We have tested the algorithm on synthetic streamer data for which the proposed method outperforms an approach where the azimuthal coordinate is ignored. Potential applications are interpolation of marine streamer data to decrease the crossline source sampling for the benefit of 3D multiple prediction and regularization to reduce sampling-related differences in processing of time-lapse data.
Constrained Dix inversion
Authors: Koren Zvi , Ravve Igor
Published: November 2006

We propose a stable inversion method to create geologically constrained instantaneous velocities from a set of sparse, irregularly picked stacking- or rms-velocity functions in vertical time. The method is primarily designed for building initial velocity models for curved-ray time migration and initial macromodels for depth migration and tomography. It is mainly applicable in regions containing compacted sediments, in which the velocity gradually increases with depth and can be laterally varying. Inversion is done in four stages: establishing a global initial background-velocity trend, applying an explicit unconstrained inversion, performing a constrained least-squares inversion, and finally, fine gridding. The method can be applied to create a new velocity field (create mode) or to update an existing one (update mode). In the create mode, initially, the velocity trend is assumed an exponential, asymptotically bounded function, defined locally by three parameters at each lateral node and calculated from a reference datum surface. Velocity picks related to nonsediment rocks, such as salt flanks or basalt boundaries, require different trend functions and therefore are treated differently. In the update mode, the velocity trend is a background-velocity field, normally used for time or depth imaging. The unconstrained inversion results in a piecewise-constant, residual instantaneous velocity with respect to the velocity trend and is mainly used for regularizing the input data. The constrained inversion is performed individually for each rms-velocity function in vertical time, and the lateral and vertical continuities are controlled by the global velocity-trend function. A special damping technique suppresses vertical oscillations of the results. Finally, smoothing and gridding (interpolation) are done for the resulting instantaneous velocity to generate a regular, fine grid in space and time. This method leads to a stable and geologically plausible velocity model, even in cases of noisy input rms-velocity or residual rms-velocity data.
Reservoir-parameter identification using minimum relative entropy-based Bayesian inversion of seismic AVA and marine CSEM data
Authors: Hou Zhangshuan , Rubin Yoram , Hoversten G. Michael , Vasco Don , Chen Jinsong
Published: November 2006

A stochastic joint-inversion approach for estimating reservoir-fluid saturations and porosity is proposed. The approach couples seismic amplitude variation with angle (AVA) and marine controlled-source electromagnetic (CSEM) forward models into a Bayesian framework, which allows for integration of complementary information. To obtain minimally subjective prior probabilities required for the Bayesian approach, the principle of minimum relative entropy (MRE) is employed. Instead of single-value estimates provided by deterministic methods, the approach gives a probability distribution for any unknown parameter of interest, such as reservoir-fluid saturations or porosity at various locations. The distribution means, modes, and confidence intervals can be calculated, providing a more complete understanding of the uncertainty in the parameter estimates. The approach is demonstrated using synthetic and field data sets. Results show that joint inversion using seismic and EM data gives better estimates of reservoir parameters than estimates from either geophysical data set used in isolation. Moreover, a more informative prior leads to much narrower predictive intervals of the target parameters, with mean values of the posterior distributions closer to logged values.
3D interpolation of irregular data with a POCS algorithm
Authors: Abma Ray , Kabir Nurul
Published: November 2006

Seismic surveys generally have irregular areas where data cannot be acquired. These data should often be interpolated. A projection onto convex sets (POCS) algorithm using Fourier transforms allows interpolation of irregularly populated grids of seismic data with a simple iterative method that produces high-quality results. The original 2D image restoration method, the Gerchberg-Saxton algorithm, is extended easily to higher dimensions, and the 3D version of the process used here produces much better interpolations than typical 2D methods. The only parameter that makes a substantial difference in the results is the number of iterations used, and this number can be overestimated without degrading the quality of the results. This simplicity is a significant advantage because it relieves the user of extensive parameter testing. Although the cost of the algorithm is several times the cost of typical 2D methods, the method is easily parallelized and still completely practical.
Effects of free-surface topography on moving-seismic-source modeling
Authors: Hestholm Stig , Moran Mark , Ketcham Stephen , Anderson Thomas , Dillen Meindert , McMechan George
Published: November 2006

A curved-grid velocity-stress formulation for viscoelastic wave modeling is used with an arbitrary number of relaxation mechanisms to model a desired [Formula: see text]-behavior. These equations are discretized by high-order staggered finite differences (FDs) in the interior of the medium, and we gradually reduce the FD order to two at the stress-free surface, where we implement our boundary conditions for an arbitrary topographic surface. A moving source is simulated along the surface of a relatively general and locally steep surface topography and, for comparison, along a plane surface. The topography consists of a significant hill surrounded by a valley. Similar two-layered geologic models are used with both topographic surfaces, with the upper layer being a lossy sedimentary layer having a relatively strong contrast with the lower, higher-velocity half-space. Local topographic highs create varying amplitude amplifications at different times during motion of the source. A pronounced wavefield accumulation is evident at the topographic highs in all components. This is very different from the even pattern produced by the same source along the same path for the plane topographic surface, even in the presence of the strong material discontinuity between the two geologic layers. The effect is, however, similar to real records for nonmoving sources of long duration; over time, the direction of incidence becomes less significant, and amplitude amplification occurs in all directions for waves trapped in a topographic high. These spatial focusing effects should be taken into account in inversion for vehicle tracking to avoid target mislocation and/or misidentification.