bluuebunny/crossref_metadata_2025 huggingface dataset:
EXPEDIENCY OF USING ENZYME PREPARATIONS IN THE PRODUCTION OF PICKETS FOR GRAPE DISTILLATES
Authors: БАХМЕТОВ Р.Н. , ШЕЛУДЬКО О.Н.
Published: July 2023

Наиболее доступный для винодельческих предприятий способ переработки виноградных выжимок – получение пикета с последующей его дистилляцией. Пектолитические ферментные препараты в виноделии в основ- ном используют при обработке виноградных сусел и мезги для повышения качества вин. В лабораторных условиях проведена оценка возможности применения пектолитического ферментного препарата Depectil Clarification для об- работки свежей сладкой выжимки. В качестве объектов исследования использовали образцы пикетов, полученные из сладкой виноградной выжимки столового белоягодного винограда сорта Илья урожая 2021 года, произрастаю- щего в коллекции ВНИИВиВ. Образец 1 готовили путем сбраживания пикета без добавления ферментного препа- рата пектолитического действия (контроль), образец 2 сбраживали с добавлением ферментного препарата. Выявле- на положительная динамика физико-химических и органолептических показателей пикета с добавкой ферментного препаратапектолитического действия по сравнению с контролем. Использование ферментного препарата позволило увеличить выход жидкой фракции пикета на 6%, ее прозрачность, сохранить цвет без оттенков, свойственных про- дуктам окисления, повысить объемную долю этилового спирта на 1,4% об., что доказывает возможность рассматри- вать нереализованную продукцию из винограда столовых сортовкак сырье для получения виноградных дистиллятов.

The most affordable way for wineries to process grape pomace is to obtain a picket with its subsequent distillation. Pectolytic enzymepreparations in winemaking are mainly used in the processing of grape pomace and pulp to improve the quality of wines. In laboratoryconditions, the possibility of using the pectolytic enzyme preparation Depectil Clarification for processing fresh sweet pomace was evaluated. The objects of the study were samples of pickets obtained from the sweet grape pomace of table white grapes of the Ilya variety of the harvest of 2021, growing in the All- Russian Research Institute for Viticulture and Winemaking collection. Sample 1 was prepared by fermentation of picket without the addition of an enzyme preparation of pectolytic action (control), sample 2 was fermented with the addition of an enzyme preparation. The positive dynamics of the physico-chemical and organoleptic parameters of the picket with the addition of an enzyme preparation of pectolytic action compared with the control was revealed. The use of an enzyme preparation made it possible to increase the yield of the liquid fraction of the picket by 6%, its transparency, preserve the color without shades characteristic of oxidation products, increase the volume fraction of ethyl alcohol by 1,4% vol., which proves the possibility of considering unrealized products from table grapes as raw materials for obtaining grape distillates.
INFLUENCE OF EXTRACTION CONDITIONS ON THE EXTRACTION OFBIOLOGICALLY ACTIVE COMPONENTS FROM PLANT RAW MATERIAL
Authors: ЕРЕМЕЕВА Н.Б. , ИВАНОВА В.А.
Published: July 2023

Лекарственное растительное сырье имеет высокий потенциал для использования в производстве пище- вых продуктов засчет большого количества биологически активных веществ, которые обладают антиоксидантными свойствами. Для полного извлеченияданных веществ необходимо правильно подобрать параметры процесса экстра- гирования. Целью исследования является изучение химического состава и его зависимости от условий экстракции бадана корневищ, цветков василька синего, побегов черники, сеннылистьев и толокнянки листьев. Одним из ключе- вых параметров экстракции является выбранный растворитель и температура процесса. На основании эксперимен- тальных данных выбраны режимы процесса получения экстракта: экстрагирование 50%-ым этиловым спиртоммето- дом мацерации при температуре 40°C в течение 240 мин, гидромодуль 1 : 10. Антиоксидантные свойства оценивали по общему содержанию фенольных веществ (эквивалент галловой кислоты) и флавоноидов (эквивалент катехина). Наблюдалось высокое общее содержание фенольных веществ (ГК) и флавоноидов (К) в экстрактах толокнянки ли- стьев и сенны листьев – 1645 мг ГК/100 г ИС, 913 мг К/100 г ИС и 1844 мг ГК/100 г ИС, 596 мг К/100 г ИС соответ- ственно, в связи с чем их рекомендуется использовать в качествекомпонентов пищевых продуктов для придания им антиоксидантных свойств.

Medicinal plant materials have a high potential for use in food production due to the large number of biologically active substances that have antioxidant properties. For the complete extraction of these substances, it is necessary to correctly select the parameters of the extractionprocess. The aim of the study is to study the chemical composition and its dependence on the extraction conditions of bergenia rhizomes, blue cornflower flowers, blueberry shoots, senna leaves and bearberry leaves. One of the key extraction parameters is the chosen solvent and process temperature. Based on the experimental data, the modes of the extract preparation process were selected: extraction with 50% ethyl alcohol by maceration at a temperature of 40°C for 240 min, hydromodulus 1 : 10. Antioxidant properties were evaluated by the total content of phenolic substances (gallic acid equivalent) and flavonoids (catechin equivalent). A high total content of phenolic substances (GA) and flavonoids (C) wasobserved in extracts of bearberry leaves and senna leaves – 1645 mg GA / 100 g Feedstock, 913 mg C / 100 g Feedstock and 1844 mg GA / 100 g Feedstock, 596 mg C / 100 g Feedstock, respectively, in connection with which they are recommended to be used as components of food productsto give them antioxidant properties.
TECHNOLOGY OF PREPARATION OF TOMATO PUMP USING PHYSICAL METHODS TO EXTRACT CAROTENOIDS
Authors: ЛИСОВАЯ Е.В. , ВИКТОРОВА Е.П. , СВЕРДЛИЧЕНКО А.В. , ЖАНЕ М.Р. , ВЕЛИКАНОВА Е.В. , УГРЮМОВА Т.И.
Published: July 2023

Выжимки томатов – перспективный источник получения каротиноидов. Как правило, извлечение бе- та-каротина и ликопина осуществляют экстракцией органическим растворителем, однако для повышения выхода целевых компонентов в экстракт необходимо проводить предварительную подготовку выжимок томатов. Цель ис- следования – изучение влияния физических методов предварительной подготовки выжимок томатов на эффектив- ность извлечения бета-каротина и ликопина. Определена эффективность обработки выжимок томатов ЭМП СВЧ, обеспечивающей переход содержащейся в них связанной воды в свободную, при этоммаксимальный эффект отмечен при темпе нагрева 1°С/с до достижения температуры 45°С. Продолжительность ИК-сушки выжимок томатов, пред- варительно обработанных ЭМП СВЧ, сократилась в 1,3 раза по сравнению с необработанными, при этом потери каротиноидов минимальны: 5,2 и 6,1% бета-каротина и ликопина соответственно по отношению к исходному со- держанию. Выявлено, что степень измельчения высушенных выжимок томатов, характеризуемая размером частиц 1 мм, обеспечивает максимальную эффективность извлечения бета-каротина и ликопина. Установлена эффектив- ность применения физических методов подготовки выжимок томатов, включая их обработку ЭМП СВЧ, последу- ющую ИК-сушку и измельчение, для получения комплекса каротиноидов, обеспечивающая максимальную степень извлечения бета-каротина и ликопина при последующей экстракции подготовленных выжимок томатов ацетоном.

Tomato pomace is a promising source of carotenoids. As a rule, the extraction of beta-carotene and lycopene is carried out by extraction with an organic solvent, however, to increase the yield of target components in the extract, it is necessary to pre-treat tomato pomace. The purpose of the study is to study the effect of physical methods of preliminary preparation of tomato pomace on the efficiency of beta-carotene and lycopene extraction. The efficiency of processing tomato pomace with EMF microwave, which ensures the transition of the bound water contained inthem into free water, was determined, while the maximum effect was noted at a heating rate of 1°C/s until a temperature of 45°C was reached. The duration of IR drying of tomato pomace, pre-treated with microwave EMF, decreased by 1,3 times compared to untreated, while the loss ofcarotenoids is minimal: 5,2 and 6,1% of beta-carotene and lycopene, respectively, relative to the initial content. It was revealed that thedegree of grinding of dried tomato pomace, characterized by a particle size of 1 mm, ensures the maximum efficiency of extraction of beta-carotene and lycopene. The effectiveness of the use of physical methods for the preparation of tomato pomace, including their processing withmicrowave EMF, subsequent IR drying and grinding, to obtain a complex of carotenoids, providing the maximum degree of extraction ofbeta- carotene and lycopene during the subsequent extraction of prepared tomato pomace with acetone, has been established.
PENDIDIKAN GIZI MELALUI SOSIALISASI GERAKAN MAKAN IKAN BAGI ANAK SEKOLAH DASAR SDN NO 14 ROMO DUGINANG KECAMATAN SANGGAU LEDO KABUPATEN BENGKAYANG
Authors: Samuddin Samuddin
Published: July 2023

Konsumsi makanan dimaksudkan sebagai sumber kalori bagi tubuh dalam melangsungkan kehidupan. Kecukupan gizi dalam makanan sangat menentukan derajat kesehatan di masa depan. Anak usia dini, seperti murid PAUD dan murid kelas 1,2 dan 3 Sekolah Dasar masih tergolong sebagai usia belia, yang sangat cepat dalam memberikan respon ketika dilakukan edukasi, dan respon tersebut akan terekam lama dalam memori anak. Demikian juga pola konsumsi makanan bagi anak, jika dibiasakan dari kecil, akan membudidaya dalam kehidupan si anak, tentunya dengan manfaat yang sudah diketahui. Tujuan dari kegiatan ini adalah mensosialisasikan gemar ikan pada anak usia dini sehingga dapat dijadikannya sebagai pola makan sehat secara konsisten, untuk tujuan terhindar dari berbagai macam penyakit infeksi. Metode kegiatan dilakukan dengan menggunakan metode ceramah dan demonstrasi makan ikan dengan berbagai olahan. Kegiatan dihadiri oleh 30 orang yang terdiri dan anak didik kelas 1,2 dan 3. PEserta mengikuti kegiatan dengan antusias serta lahap makan ikan hasil olahan dalam kegiatan tersebut.Kata kunci : sosialisasi, konsumsi, gizi,  anak usia dini, kalori
PELATIHAN PEMIJAHAN IKAN LELE BAGI PEMBUDIDAYA IKAN DI DESA DEMIT KECAMATAN SANDAI KABUPATEN KETAPANG
Authors: Utami Pratita Budi
Published: July 2023

Mata pencarian utama bagi masyarakat Desa Demit Kecamatan Sandai yaitu berkebun dan bertani. Namun terdapat beberapa rumah tangga yang melakukan kegiatan budidaya ikan lele dan ikan nila. Kegiatan budidaya ini dilakukan sebagai pemenuhan konsumsi protein hewani rumah tangga, serta sebagai salah satu pendapatan rumah tangga yang dipasarkan secara lokal. Salah satu kendala yang ada pada kegiatan budidaya tersebut adalah bibit lele masih bergantung pada pasokan bibit yang berasal dari daerah lain. Permasalahan ini yang kemudian mendorong kegiatan PKM Dosen Universitas Tanjungpura untuk dapat melatih keterampilan remaja Desa Demit untuk dapat melakukan pemijahan dan pembenihan lele. Kegiatan PKM dilakukan dengan menggunakan dua metode yaitu, sosialisasi teori pemijahan dan pembenihan; serta kegiatan praktik pemijahan dan pembenihan lele. Peserta dalam kegiatan ini adalah dua kelompok remaja, yang masing-masing kelompok terdiri dari tujuh anggota. Pada kegiatan peyampaian teori pemijahan dan pembenihan, materi yang disampaikan adalah strategi serta kunci keberhasilan dalam upaya pemijahan dan pembenihan lele. Kemudian pada kegiatan praktik dilakukan identifikasi calon indukan yang baik, perlakuan pada indukan di kolam pemijahan, kemudian perlakukan pada telur di kolam penetasan sampai dengan pendederan, sampai dengan perawatan benih agar siap dipindahkan ke kolam pembesaran. Berdasarkan praktik yang telah dilakukan, hasil pemijahan indukan lele menghasilkan lebih dari 1.000 telur. Telur-telur yang menetas dan bertahan hingga mencapai ukuran anakan sejumlah 140 ekor (pesentase daya tetas telur sampai dengan mencapai ukuran anakan berada pada angka 14%). Kemudian pada kegiatan monitoring dan evaluasi PKM, peserta pelatihan menggunakan metode yang sebelumnya sudah disampaikan untuk melakukan pembenihan lele secara mandiri. Sehingga anakan lele yang dihasilkan digunakan kelompok sebagai anakan yang akan dibesarkan di kolam pembesaran. Keterampilan pembenihan ini cukup signifikan bagi kelompok pembudidaya dalam menekan biaya produksi.    Kata Kunci : Sandai, Pemijahan Mandiri
PEMETAAN SEBARAN PRASARANA DAN BATAS DESA PELAPIS KECAMATAN KEPULAUAN KARIMATA KABUPATEN KAYONG UTARA
Authors: Saputra Robin , Zibar Zan , Raynaldo Adityo , Shofiyah Sofi Siti , Marista Etha , Linda Riza
Published: July 2023

Penyelenggaraan pemerintahan yang baik harus didukung dengan data yang baik agar dalam mengelola desa dapat dengan optimal. salah satu data yang penting adalah peta batas wilayah desa. Pembuatan peta batas desa merupakan amanat yang tertuang dalam Undang-undang Nomor 6 Tahun 2014 tentang Desa. Tujuan dari kegiatan ini adalah tersedianya peta desa dalam bentuk fisik untuk mendukung pemerintah desa dalam menjalankan fungsi pemerintahannya. Kegiatan pembuatan peta desa melibatkan pihak desa dan masyarakat. Hasil kegiatan pemetaan desa ini dapat diselesaikan dengan baik dan berjalan lancar sesuai dengan rencana yang telah ditentukan. Berdasarkan hasil evaluasi dan pernyaatan pihak desa peta yang dihasilkan juga representatif untuk kebutuhan administrasi desa. Pemerintah desa juga menganggap bahwa kegiatan ini bermanfaat, dan berharap kedepannya ada kegiatan yang sejenis, dengan target keluaran sampai ke peta batas dusun, RT dan RW.
Value and risks of morphing technology into strategy and business model
Authors: Denisova A. L. , Lopatnikov A. N.
Published: July 2023

Digital technologies became the primary source of innovation in the private and public sectors. The Internet profoundly changed the way businesses are run catapulting “most digital” industries and companies to the top of the S&P500. Two innovations that drive digital transformation changing the nature of competition are cloud computing and artificial intelligence (AI) technologies. Cloud-native business models and strategies proved successful in various industries, while AI is being tested in vivo by management mainstream. The publication provides an analysis of a multidimensional impact cloud computing makes on strategies and business models of companies. We show that what made cloud computing special in the management context was the way it morphed into strategies and business models best suited for the uncertain future. We also noted that as the focus of digital transformation shifts towards cloud-based AI powered decision-making solutions, managing the human aspect of “more digital” business models and related risks, recently referred to as an existential threat, becomes a priority of management research.
Discovery of fully synthetic FKBP12-mTOR molecular glues
Authors: Deutscher Robin C.E. , Meyners Christian , Schäfer Sabine C. , Repity Maximilian L. , Sugiarto Wisely Oki , Kolos Jürgen , Heymann Tim , Geiger Thomas M. , Knapp Stefan , Hausch Felix
Published: July 2023

Molecular glues are a class of drug modalities with the potential to engage otherwise undruggable targets. However, the rational discovery of molecular glues for desired targets is a major challenge and most known molecular glues have therefore been discovered by serendipity. Here we present the first fully synthetic FKBP12-mTOR molecular glues, which were dis-covered from a FKBP-focused, target-unbiased ligand library. Our biochemical screening of >1000 in-house FKBP ligands yielded one hit that induced dimerization of FKBP12 and the FRB domain of mTOR. The crystal structure of the ternary complex revealed the binding mode of this hit, which bound to the same surface area as rapamycin, but with a radically dif-ferent interaction pattern. Structure-guided optimization improved potency 500-fold and led to compounds, which initiate FKBP12-FRB complex formation and S6 kinase inhibition in cells. Our results show that molecular glues targeting flat surfac-es can be discovered by focused screening and support the use of FKBP12 as a versatile accessory protein for molecular glues.
Difluoromethyl-1,3,4-oxadiazoles are selective, mechanism-based, and essentially irreversible inhibitors of histone deacetylase 6
Authors: König Beate , Watson Paris R. , Reßing Nina , Cragin Abigail D. , Schäker-Hübner Linda , Christianson David W. , Hansen Finn Kristian
Published: July 2023

Histone deacetylase 6 (HDAC6) is an important drug target in oncology and non-oncological diseases. Most available HDAC6 inhibitors (HDAC6i) utilize a hydroxamic acid as zinc-binding group which limits the therapeutic opportunities due its genotoxic potential. Recently, difluoromethyl-1,3,4-oxadiazoles (DFMOs) were reported as potent and selective HDAC6i, but their mode of inhibition remained enigmatic. Herein, we report that DFMOs act as mechanism-based and essentially irreversible HDAC6i. Biochemical data confirm that DFMO 6 is a tight-binding HDAC6i capable of inhibiting HDAC6 via a two-step slow-binding mechanism. Crystallographic and mechanistic experiments suggest that the attack of 6 by the zinc-bound water at the sp2 carbon closest to the difluoromethyl moiety followed by a subsequent ring opening of the oxadiazole yields the deprotonated difluoroacetylhydrazide 13 as active species. The strong anionic zinc coordination of 13 and the binding of the difluoromethyl moiety in the P571 pocket finally results in an essentially irreversible inhibition of HDAC6.
Roles of the tyrosine diiron ligand of a mycobacterial hemerythrin-like protein on spectroscopic and redox properties, and catalase and nitric oxide reactivities
Authors: Martin Christopher , Ma Zhongxin , Holland Ashley , Nogueira Maria Luiza Caldas , Davidson Victor , Caranto Jonathan
Published: July 2023

Tyrosine-ligated hemerythrin-like proteins (HLPs) are uniquely found in pathogenic mycobacteria. There is evidence that these HLPs have roles in virulence. To test the precise role of this tyrosine ligand, a Y54F HLP variant of Mycobacterium kansasii (Mka) was generated. There are substantial spectroscopic differences for the Y54F and the wild-type HLPs. First, the UV-visible absorbance spectrum of Y54F HLP lacked a 500-nm absorbance feature prevalent in the spectra of wild-type HLP and other Tyr-ligated diiron proteins. In addition, EPR spectroscopy showed that the Y54F HLP was isolated in a mixed-valent (FeII-FeIII) state, whereas wild-type HLP was isolated in the diferric state. In addition, the mixed-valent state of Y54F HLP exhibited a narrow, nearly axial EPR signal with g-values of 1.97, 1.93, and 1.89, a signal that is consistent with a µ-oxo bridged mixed-valent diiron site. Meanwhile, the wild-type counterpart exhibited a broad rhombic signal with simulated g-values of 1.99, 1.83, and 1.62, which is consistent with a µ-hydroxo bridged mixed-valent diiron site. Our results are consistent with Y54 coordination to the diiron site and indicate this ligand lowers the diiron [FeIII]2/FeIIFeIII redox couple and increases the basicity of the diiron solvent bridge. With regards to substrate reactivity, the Y54F mutation had no discernable effect on reductive nitrosylation reactivity, however, it precluded formation of the 520-nm intermediate observed when NO is reacted with wild-type Mka HLP. In addition, the Y54F mutation nearly eliminated catalase activity and greatly perturbed NO peroxidase activity. These results suggest that the Y54 ligand is critical for scavenging of H2O2 and NO, both of which are encountered during infection due to the host defense response.
Electroreductive Deoxygenative C–H and C–C Bond Formation from Non-Derivatized Alcohols Fueled by Borohydride Oxidation
Authors: Villo Piret , Lill Malin , Alsaman Zainab , Soto Kronberg Adrian , Ahumada Guillermo , Agarwala Hemlata , Ahlquist Mårten , Lundberg Helena
Published: July 2023

Alcohols are one of the most common organic compound classes among natural and synthetic products. Thus, methods for direct removal of C–OH groups without the need for wasteful pre-functionalization are of great synthetic interest to unlock the full synthetic potential of the compound class. Herein, electroreductive C–OH bond activation and subsequent deoxygenative C–H and C–C bond formation of benzylic and propargylic alcohols is demonstrated. Experimental and theoretical studies indicate that the reductive C–OH bond cleavage furnishes an open shell intermediate that undergoes a radical-polar crossover to the corresponding carbanion that subsequently undergoes protonation to furnish alkane products. Furthermore, we demonstrate the carbanion can be trapped with CO2 to form arylacetic acids, representing the first example of deoxygenative electrochemical C–C bond formation from non-derivatized alcohols. The cathodic transformations are efficiently balanced by the anodic oxidation of borohydride additives, a strategy that serves as a highly attractive alternative to the use of sacrificial metal anodes.
Metal- and chlorine-free cross-dehydrogenative coupling of azaarenes with alkanes without sacrificial oxidants.
Authors: Laze Loris , Quevedo-Flores Beatriz , Bosque Irene , Gonzalez-Gomez Jose C.
Published: July 2023

Minisci-like cross-dehydrogenative coupling of azaarenes with unactivated alkanes offers an appealing approach to bioactive alkyl-substituted heterocycles from abundant feedstocks. Traditionally, this net oxidative C-C bond formation process uses sacrificial chemical oxidants with the consequent waste generation. Here we report a chemical oxidant-free solution for this transformation, promoted by visible light at room temperature in the absence of metals, chlorinated solvents, or chlorine sources. The reaction is run under conventional photochemical conditions and does not require deoxygenation or anhydrous solvents. Remarkably, a readily available 9-arylacridine and the inexpensive pyridine N-oxide are used as catalyst precursors. A wide range of azaarenes and C-H partners are compatible with this protocol, which was applied to the late-stage functionalization of bioactive molecules. In addition, the gram scale synthesis of one API intermediate was accomplished using flow technology. Preliminary mechanistic studies were conducted to support the dual catalytic cycle.
Dissecting morphogenetic apoptosis through a genetic screen in Drosophila
Authors: Barbaste Audrey , Schott Sonia , Benassayag Corinne , Suzanne Magali
Published: July 2023

Apoptosis is an essential cellular process both in normal development and pathological contexts. Screens performed to date have focused on the cell autonomous aspect of the process, deciphering the apoptotic cascade leading to cell destruction through the activation of caspases. However, the nonautonomous aspect of the apoptotic pathway, including signals regulating the apoptotic pattern or those sent by the apoptotic cell to its surroundings, is still poorly understood. Here, we describe an unbiased RNAi-based genetic screen whose goal is to identify elements of the “morphogenetic apoptosis pathway” in an integrated model system, theDrosophilaleg. We screened about 1,400 candidates, using adult joint morphology, morphogenetic fold formation, and apoptotic pattern as readouts for the identification of potential apoptosis-related genes. We identified 41 genes potentially involved in specific aspects of morphogenetic apoptosis: (1) regulation of the apoptotic process; (2) formation, extrusion, and elimination of apoptotic bodies; and (3) contribution to morphogenesis downstream of apoptosis.
KORELASI ANTARA FRAILTY DENGAN DEPRESI PADA LANJUT USIA
Authors: Makmur Shania , Saelan Tadjudin Noer
Published: July 2023

Elderly people in Indonesia are increasing in number and with increasing age there are changes such as threat of death, retirement, stressful life events or medical problems. It's normal to feel uncomfortable, stressed or sad about change. But if this feeling lasts for a long time, then there is a possibility of depression. Some people may experience depression after being diagnosed with a physical illness. Physical illness increases the risk of developing severe depression, so that there is a causal or mutually amplifying relationship in the comorbidity of psychological illness with physical illness. Frailty is theoretically a clinically recognizable state of increased susceptibility. Physical frailty and depression are common comorbid conditions that have an important impact on the elderly, so it is important to further research and confirm the relationship between frailty and depression to provide information and knowledge as a preventive measure and reduce the risk that can occur in the elderly. The study used a cross-sectional analytic study with a total population sampling technique. The study used the RAPUH questionnaire and the Geriatric Depression Scale (GDS) 15. The results showed that the elderly were classified as severe depression (6.2%), moderate depression (8.6%), mild depression (27.2%) and not depressed ( 58%). The elderly were also found to be frail (53.1%), pre-frail (44.4%) and robust (2.5%). Research on the relationship between frailty syndrome and depression scale was proven by Chi – Square test (P=0.000). The results of the relationship between frailty syndrome and depression scale were found to be P-value 0.05 so that in conclusion there was a significant relationship between frailty syndrome and depression in the elderly.
READINESS OF INTERPROFESSIONAL EDUCATION IN COMMUNITY MEDICINE: MEDICAL AND DENTISTRY STUDENTS
Authors: Faizin Chamim
Published: July 2023

Abstract The condition of public health is a reflection of the level of complexity of health problems. Many health care systems have innovated but failed in the practice of collaboration, teamwork, and communication. Family-based care will ease the workload of doctors and improve the level of health for patients in the community. Interprofessional education program was designed to increase of collaborative practice and teamwork among health team. This review aims to analyze the readiness of interprofessional education (IPE) in medical and dentistry students in collaborative field practice community medicine with a family approach. Quantitative methods using cross sectional with the readiness interprofessional learning scale (RIPLS). Total sampling with 142 medical students and 43 dental students carried out collaborative practice on 16 families to find priority health problems and carry out preventive interventions. The average readiness of interprofessional education descriptively for students is 65.36% (range 50%-76%). 100% student ready for interprofessional education. No difference among medical and dentistry student in readiness of interprofessional education with p value 0,810 (0,05). That all student ready to interprofessional education community medicine with family approach. Key words            : readiness, interprofessional education, community medicine, medical students, dental students
Evaluasi Kualitas Udara Pada Ruang Kelas di Sekolah Sekitar Kawasan Pabrik Semen Tonasa
Authors: Mutmainnah Nur , Larosa Esta , H Salmiah Zainuddin
Published: July 2023

Kualitas udara dalam ruang telah menjadi perhatian penting karena memberikan masalah terhadap kesehatan manusia. Hal ini berkaitan dengan aktivitas manusia yang menghabiskan kurang lebih 90 persen waktunya di dalam ruangan. Penelitian ini bertujuan mengidentifikasi karakteristik kualitas udara pada ruang kelas dengan sistem ventilasi alami pada sekolah yang berada pada ring 1 kawasan pabrik Semen Tonasa II Kabupaten Pangkep Sulawesi Selatan. Pengukuran kualitas udara berfokus pada konsentrasi CO, CO2, kadar debu total, suhu, kelembapan udara dan kecepatan aliran udara. Hasil penelitian menunjukkan Konsentrasi CO dan CO2 pada tiga ruang kelas berada di bawah rekomendasi yang dipersyaratkan DOSH dan ASHRAE. Hal ini menunjukkan kualitas udara yang baik dalam ruang kelas dapat dipertahankan dengan sistem ventilasi alami yang digunakan. Untuk pengukuran kadar debu total berada diatas ambang batas yang dipersyaratkan oleh Keputusan Menteri Kesehatan RI No.1405/MENKES/SK/XI/2002. Selain itu terdapat hubungan yang relatif berpengaruh (p0.05) antara polutan udara dengan faktor meteorologi seperti temperatur, dan kelembapan udara pada ruang kelas. Studi menemukan bahwa adanya pengaruh dari lokasi dan lingkungan sekitar sekolah serta jumlah dan aktivitas manusia terhadap nilai konsentrasi polutan pada ruang kelas.
Analisis Karakteristik Spasial Ruang dan Bentuk Fasad Rumah Tradisional Paneng-Paneng di Kabupaten Sidrap Berdasarkan Konsep Nilai-Nilai Islam
Authors: Akbar Andi Muhammad , Setiawati Nur
Published: July 2023

Fenomena maraknya pembangunan rumah tradisional Bugis modern “paneng-paneng” di kabupatenSidrap yang lagi tren saat ini, diduga telah mengabaikan kearifan lokal tradisi upacara ritual pada perencanaandan perancangan spasial ruang serta bentuk fasadnya, karna dianggap bertentangan ajaran Islam dan sudahketinggalan jaman. Tujuan penelitiannya menganalisis karakteristik spasial ruang dan bentuk fasad rumahtradisional Paneng-Paneng di Kabupaten Sidrap berdasarkan konsep nilai-nilai Islami yang dipengaruhilingkungan sosial, budaya dan ekonomi. Metode penelitiannya kualitatif, paradigmanya naturalistis danpembahasannya induktif, pendekatannya lebih menekankan eksplorasi kealamian serta kedalaman sumber datasebagai instrumen menetapkan fokus penelitian. Kategori sampel terpilih adalah rumah tradisional BugisPaneng-paneng pada tahap pra konstruksi, konstruksi dan pasca konstruksi. Hasil penelitian ini menemukanbahwa meskipun kegiatan upacara ritual sudah diabaikan oleh pemilik rumah Paneng-Paneng, namun maknadan simbolis pada karakteristik spasial ruang serta bentuk fasadnya sebagai fungsi rumah tradisional Bugismasih tetap terjaga keutuhannya sebagai sarana interaksi sosial dalam menjaga tradisi budaya Bugis dan tidakbertentangan dengan nilai-nilai ajaran Islam. Hal ini dapat terlihat pada pembagian spasial ruang luarnyayang terbentuk oleh batas-batas ruang yang jelas dengan gradasi sifat ruang publik, semi publik dan privatyang didasari pada perbedaan fungsi ruangnya sedangkan bentuk fasadnya yang tertutup dengan rapat dan tegasmenciptakan privasi bentuk visual dan privasi jarak pandang yang merupakan karakteristik sosial utama dalamkonsep Islami (Qur’an, Su.24:30).
Pengaruh Pendampingan Orang Tua Terhadap Kesehatan Mental Siswa Sekolah Dasar Dalam Pembelajaran Jarak Jauh
Authors: Utami Ihda Hidayati Putri , Thohir M. Anas
Published: July 2023

Pembelajaran jarak jauh yang dilakukan secara daring seharusnya menjadi tanggung jawab orang tua untuk mendampingi anaknya sebagai pengganti guru. Tujuan penelitian ini adalah untuk mengetahui pengaruh pendampingan orang tua terhadap kesehatan mental siswa sekolah dasar dalam pembelajaran jarak jauh. Metode kualitatif yang dilakukan dengan pendekatan studi kasus, dan dengan partisipan yang berjumlah 10 orang peserta didik siswa kelas V di salah satu Sekolah Dasar di Tulungagung. Siswa tersebut berumur 9-10 tahun. Pengambilan sample dilakukan dengan purposif sampling dan data analisis data dilakukan secara deskriptif. Pada penelitian ini menggunakan dua teknik pengumpulan data yaitu kuesioner dan wawancara. Dari hasil penelitian dapat disimpulkan bahwa pendampingan orang tua berpengaruh terhadap kesehatan mental siswa sekolah dasar dalam pembelajaran jarak jauh. Namun ditemukan banyak faktor yang menjadi penghambat dalam pendampigan orang tua salah satu faktor utama penghambat adalah kesibukan orang tua dan kesiapan orang tua sebagai pengganti guru. Selama pembelajaran jarak jauh berlangsung anak merasa jenuh akibat pembelajaran yang terkesan monoton dan anak berkemungkinan besar mengalami kecanduan handphone.
HUBUNGAN KECERDASAN EMOSIONAL DAN MOTIVASI BELAJAR DENGAN HASIL BELAJAR SISWA SDN DI KECAMATAN PANAKKUKANG KOTA MAKASSAR
Authors: Hakim Ulfayani , H Nurhikmah , Tirtaraharja Umar
Published: July 2023

This research aimed at: (1) describing student’s emotional quotion, learning motivation, and learning achievement, (2) find out the correlation of student’s emotional quotion and learning achievement, (3) find out the correlation of student’s learning motivation and learning achievement, and (4) find out the correlation between student’s emotional quotion and learning motivation to learning achievement. This type of research is ex post facto with correlational. The population in the study were all student of elementary school at Panakkukang District Makassar City. The sample in the study are 150 student from 3 elementary school that choosen by multistage sampling. The data obtained from samples were analyzed by simple correlation and multiple regression. The result shows: (1) student’s emotional quotion, learning motivation, and learning achievement are in good category, (2) there is a correlation of emotional quotion and learning achievement on Student in State Elementary School at Panakkukang District Makassar City, (3) there is a correlation of learning motivation and learning achievement on Student in State Elementary School at Panakkukang District Makassar City, (4) there is a correlation between emotional quotion and learning motivation to learning achievement on Student in State Elementary School at Panakkukang District Makassar City. The conclusion from the results of this study is that there is a relationship between emotional intelligence and learning motivation with the learning achievement of SDN students in Panakkukang District, Makassar City.
HUBUNGAN MINDSET TERHADAP MOTIVASI BELAJAR PESERTA DIDIK SEKOLAH DASAR DI DEPOK
Authors: Ernawati Ernawati , Syarifah Nur , Habibah Rini Yaumi , Ardah Feni Kurniawati
Published: July 2023

This study aims to determine the relationship between mindset and learning motivationelementary school students and find out the obstacles to learning motivation and look for thesolution. The type of research used in this research is quantitative research.The population in this study was grade V and grade VI elementary school in Depok with the number of samples is 112 students for the academic year 2022/2023. Data collection techniques that used are questionnaires and observations. From the calculation results obtained a correlation test of 0.570 which is in the medium interval. This shows that the relationship between mindset and learning motivation. The obstacles come from students who less motivated when learning in class and outside the classroom. The solution is awareness of students, conducted training for teachers and parents, teachers foster motivation students by creating a pleasant atmosphere, linking learning with everyday life.
The Effect of Financial Ratios, Firm Size, and Cash Flows from Operating Activities on Earnings per Share
Authors: Saleh Besan Abdallah
Published: July 2023

Purpose: The study aims to examine the effect of Financial Ratios, Firm size, and Cash Flows from Operating Activities on Earnings per Share.

 

Theoretical framework: Earnings per share are one of the crucial matters of concern to dealers in securities because of their important role in evaluating investments and the risks surrounding them. Since earnings per share are affected by several factors.

 

Design/Methodology/Approach: The study sample consisted of industrial companies listed on the Palestine Exchange during the period 2016–2020. Secondary sources were used to collect study data.

 

Findings: The results of the study showed that there is a statistically significant effect of each company's size and financial leverage on stock returns. However, the results of the study showed that there was no statistically significant effect for each of the liquidity and operating cash flows on the returns per share.

 

Research, practical & social implications: We can consider that financial ratios, return on equity, debt to equity, price to book value, and cash flow from operating activities altogether affect earnings per share.

 

Originality/Value: The results of this study provide evidence for stakeholders to be able to judge the efficiency of firms by understanding the factors that affect the size and stability of earnings per share.
The Role of Compensation, Job Rotation, Employee Engagement and Employees Performance of SMEs
Authors: Ambarwati Titiek , Wardhana Ery Tri Djatmika Rudijanto Wahyu , Wardoyo Cipto , Churiyah Madziatul , Jihadi Muhammad
Published: July 2023

Purpose: The purpose of this study is to analyze the relationship between compensation and employee performance, analyze the relationship between job rotation and employee performance, and analyze employee engagement on employee performance in SMEs.
 
Design/Methodology/Approach: The method used in this study is quantitative to test the hypothesis taken from the research variables in numbers and then the data is analyzed using statistical procedures. This study explains the causal relationship between variables through hypothesis testing. The population in this study were 670 SMEs owners. Data collection techniques in research were carried out by distributing questionnaires containing statements related to the variables studied. The measurement scale used for this research is a 7-point Likert scale. Data analysis uses the Partial Least Square (PLS) method.
 
Findings: The results of this study are compensation has a significant effect on employee performance, job rotation has a significant effect on employee performance, employee engagement has a significant effect on employee performance
 
Practical implications: SMEs managers should implement compensation, job rotation to encourage employee performance improvement and also to encourage employee engagement  to improve SME employee performance.
 
Authenticity/Value: The novelty of this research is the discovery of a relationship model of compensation, job rotation, Employee Engagement and performance of SMEs employees.
Efficiency and relevance of post-exposure prophylaxis prescription by emergency physicians: a monocentric retrospective study
Authors: Eyer Xavier , Yordanoff Youri , Pateron Dominique , Plaisance Patrick , Chauvin Anthony
Published: July 2023

Background: Preventing infection with HIV remains a major public health challenge. Exposed persons are offered support and quick access to the post-exposure prophylaxis (PEP) by hospital emergency services. This study aimed to investigate the accuracy of the prescription of emergency PEP for patients with sexual fluid exposure in a French emergency department (ED) by comparing data in medical files and actual prescriptions. Methods: We retrospectively collected data for patients consulting for sexual exposure in a single Parisian ED from 2015 to 2016. For each patient, researchers independently checked whether the emergency physician prescribed PEP according to French guidelines. Our primary outcome was the appropriateness of the emergency PEP prescription after sexual fluid exposure. We calculated the Cohen weighted kappa coefficient with its 95% confidence interval (CI) for determining the agreement in indication for PEP. Results: We included 346 patients in the analysis. Half of the patients were men who had sex with men (n=178). The most frequent sexual exposure was anal insertive or receptive (n=177; 51%). PEP was prescribed in 94% of cases (n=328). In 33 cases (10%) the indication for PEP was not clear, but PEP was prescribed in 17 cases (52%). The Kappa value for determining the indication for PEP was 0.55 (95% confidence interval 0.36-0.74), indicating poor agreement for prescription. The agreement was lowest for men who had sex with men: 0.29 (0.05-0.53). Conclusion: Strategies are needed to improve the relevance of the prescription of PEP in French EDs to avoid the excess secondary effects and cost.
Klasifikasi Jenis Kulit Wajah menggunakan Backpropagation Neural Networks Berbasis GLCM
Authors: HERYANTO M. ARY , JUANANTA DENY , SADANARESWARI AGATA , WULANDARI SARI AYU
Published: July 2023

ABSTRAKKulit wajah sangat sensitif dibandingkan dengan bagian tubuh lainnya. Ada beberapa jenis kulit wajah, yaitu normal, berminyak, dan kering. Namun, terkadang mengidentifikasi jenis kulit wajah seseorang dengan benar bisa menjadi masalah karena terdapat lima jenis kulit wajah yang berbeda. Untuk mengatasi kesulitan dalam mengidentifikasi jenis kulit wajah, pada penelitian ini diterapkan metode klasifikasi Backpropagation Neural Network berbasis GLCM. Penelitian ini menggunakan tiga jenis kulit wajah, yaitu: kering, berminyak, dan normal. Sedangkan untuk mencari model arsitektur yang tepat dilakukan dengan cara variasi jumlah hidden layer dan jumlah neuron per hidden layer. Setelah dilakukan beberapa pengujian didapatkan hasil akurasi 96.70% untuk model sembilan lapisan tersembunyi dengan enam neuron pada tiap lapisan tersembunyi.Kata kunci: kulit wajah, klasifikasi, backpropagation neural network, GLCM. ABSTRACTFacial skin is very sensitive compared to other body parts. There are several facial skin types: normal, oily, and dry. However, sometimes correctly identifying a person's facial skin type can be problematic because there are five different skin types. To overcome difficulties in identifying facial skin types, this study applied the GLCM-based Backpropagation Neural Networks classification method. This study used three types of facial skin, namely: dry, oily, and normal. Meanwhile, finding the right architectural model is done by varying the number of hidden layers and the number of neurons per hidden layer. After several tests, the results obtained an accuracy of 96.70% for the nine hidden layers model with six neurons for each hidden layer.Keywords: facial skin, classification, backpropagation neural network, GLCM.
Perencanaan Implementasi Low Band 700 Mhz Pasca ASO untuk Seluler 5G di Indonesia
Authors: ARYANTA DWI , MAULANA MUHAMMAD IRFAN
Published: July 2023

ABSTRAKBand 700 MHz merupakan golden frequency pasca ASO yang potensial untuk implementasi 5G pada Low Band dengan kelebihan jangkauan luas dan penetrasi gedung lebih baik. Penelitian ini membandingkan penggunaan lebar pita 15 MHz dan 20 MHz untuk melihat kebutuhan jumlah BTS suatu operator seluler dan biaya investasi selama sepuluh tahun perencanaan. Sampai dengan tiga tahun pertama perencanaan, jumlah BTS 5G dihitung berdasarkan pendekatan coverage dimensioning, setelahnya menggunakan perhitungan capacity dimensioning akibat peningkatan kapasitas trafik data. Untuk penambahan lebar pita dari 15 MHz menjadi 20 Mhz berdampak pada penghematan jumlah BTS, sampai dengan tahun 2032 untuk lebar pita 15 MHz diperlukan 26.033 BTS dan 19.427 BTS untuk lebar pita 20 MHz. Penghematan jumlah BTS menekan biaya implementasi selama 10 tahun sebesar sebesar 8.280 milyar rupiah dalam Present Value, besarnya cost reduction keseluruhan atas penambahan lebar pita ini sebesar 1.457 milyar rupiah per tahun dan Cost Reduction per MHz sebesar 146 milyar rupiah.Kata kunci: golden frequency, ASO, 5G, low band, cost reduction. ABSTRACTThe 700 MHz band is the post-ASO golden frequency which has the potential to implement 5G in the Low Band with the advantages of wide coverage and better building penetration. This study compares the use of 15 MHz and 20 MHz bandwidth to see the number of base stations needed by a cellular operator and the investment costs for 10 years of planning. Up to the first 3 years of planning, the number of 5G BTS was calculated based on the coverage dimensioning approach, after which it used capacity dimensioning calculations due to an increase in data traffic capacity. The addition of bandwidth from 15 MHz to 20 Mhz has an impact on saving the number of BTS, until 2032 for a bandwidth of 15 MHz, 26,033 BTS are needed and 19,427 BTS for a bandwidth of 20 MHz.Savings in the number  of BTS reduce implementation costs for 10 years by 8,280 billion rupiah in Present Value, the overall cost reduction for this additional bandwidth is 1,457 billion rupiah per year and Cost Reduction per MHz is 146 billion rupiah.Keywords: golden frequency, ASO, 5G, low band, cost reduction.
Alat Bantu Koordinasi Jarak Dan Posisi Disabilitas Netra Berbasis Radio Frekuensi Menggunakan Haversine-Bearing
Authors: Supriyadi Tata , Setiadi Budi , Jadmiko Sarjono Wahyu , Sudrajat Sudrajat , Utomo T B , Fadhillah Luthfi Nur , Fescara Moch Firdan
Published: July 2023

ABSTRAKAplikasi talkback pada gawai android mengharuskan tersedia pulsa atau data internet serta penggunaan tongkat konvensional tidak dapat berkomunkasi antar sesama pengguna disabilitas netra. Penelitian ini membuat alat bantu komunikasi antar disabilitas dengan luaran informasi jarak dan posisi sudut. Setiap alat bantu menghasilkan koordinat titik latitude longitude dari Global Positioning System (GPS). Data koordinat titik antar alat bantu saling dikirim menggunakan radio frekuensi Long Range (LoRa). Kedua koordinat titik diolah menggunakan algoritma Haversine untuk menghasilkan jarak. Sedangkan algoritma Bearing digunakan untuk menghasilkan posisi sudut dengan referensi utara dari sensor kompas. Rata-rata kesalahan jarak tanpa halangan 2,41 m, dengan halangan 4,78 m, pada Received Signal Strength Indicator (RSSI) -107,55 dBm. Kesalahan sudut tanpa halangan 14,52â° , dengan halangan 24,51â° pada RSSI -102,1 dBm.Â ABSTRACTThe talkback application on android devices requires that credit or internet data be available and the use of conventional sticks cannot communicate between users with visual impairments. This study makes communication aids between disabilities with the output of distance and angle position information. Each tool generates latitude longitude coordinates from the Global Positioning System (GPS). The coordinates of the points between the tools are sent to each other using Long Range (LoRa) radio frequencies. Both point coordinates are processed using the Haversine algorithm to produce distances. While the Bearing algorithm is used to generate an angular position with a north reference from the compass sensor. The average distance error without an obstacle 2.41 m, with obstacle is 4.78 m on the Received Signal Strength Indicator (RSSI) -107.55 dBm. Angle error without an obstacle 14.52â° , with obstacle is 24.51â°, on RSSI -102.1 dBm.