bluuebunny/crossref_metadata_2025 huggingface dataset:
Considerations on control processes in aeronautical organizations in the context of improving safety and efficiency
Authors: IORDACHE Valentin-Marian , PIETREANU Casandra Venera
Published: March 2019

In modern aeronautical systems, one of the biggest challenges for the management structures is to maintain the control at all levels. Operational safety and efficiency impose the need to control all the associated risks and hazards; thus, in order to achieve organizational performance, a very important aspect is to establish and develop a strong organization with respect to operations and objectives. Nevertheless, performance cannot be achieved without control; the continuous technological development and the environmental variabilities have a great impact on the organizational management processes. Organizations are very complex and they will continue to expand due to the increasing demands of flight operations. The capacity to adapt, considering the permanent transformations in the society, represents a continuous process that needs to be carefully carried in order to diminish or eliminate the errors that may occur due to organizational factors. Controlling each operational step from the beginning represents the premises for obtaining stability and performance.
Simulation Study of the Aerodynamic Force Distributions on the UAS-S45 Baalam Wing with an
Upswept Blended Winglet
Authors: AUBEELACK Hema , BOTEZ Ruxandra Mihaela
Published: March 2019

In this paper, the wing on the Unmanned Aerial System UAS-S45 Bàalam from Hydra Technologies is modeled and studied so that its aerodynamics and baseline performance can be better understood. More specifically, the performance of the wing, with and without a detachable upswept blended winglet, is investigated. Using detailed CFD results, the impact of this winglet is demonstrated through its effect on the spanwise distributions of forces and moments along the wing.
Temperature Effects on Damage Mechanisms of Hybrid Metal – Composite Bolted Joints Using SHM Testing Method
Authors: COMAN Calin-Dumitru , DIMA Ion , HOTHAZIE Stefan , PELIN George , SALAORU Tiberiu
Published: March 2019

This paper presents the quasi-static thermo-mechanical loading effects on the progressive damage mechanisms and failure modes of the single-bolt, single-shear, hybrid metal-composite, bolted joints in aerospace applications. A three-dimensional finite element method (FEM) technique was used to model the countersunk head bolted joint in details, including geometric and frictional based contact full nonlinearities and using commercial software PATRAN as pre/post-processor. The progressive damage analysis (PDA) in laminated (CFRP/ vinyl ester epoxy) composite material including nonlinear shear behavior, Hashin-type failure criteria and strain-based continuous degradation rules for different values of temperatures was made using SOL 400 NASTRAN solver. In order to validate the numerical results and close investigation of the fracture mechanisms for metal-composite bolted joints by determining ultimate failure loads, experiments were conducted in temperature controlled chamber using SHM (Structural Health Monitoring) technique. The results show that the thermal effects are not negligible on failure mechanism in hybrid aluminum-CFRP bolted joints having strong different thermal expansion coefficients. The complex 3D FEM model using advanced linear continuum solid-shell elements proved computational efficiency and ability to accurately predict the various failure modes as bearing and shear-shear out, including the temperature effects on the failure propagation and damage mechanism of hybrid metal-composite bolted joints.
Using genetic algorithms to optimize airfoils in incompressible regime
Authors: DINA Adrian , DANAILA Sterian , PRICOP Mihai-Victor , BUNESCU Ionut
Published: March 2019

Aerodynamic optimization is a very actual problem in aircraft design and airfoils are basic two-dimensional shape forming cross sections of wings. Traditionally, the airfoil geometry if defined by a very large number of coordinates. Nowadays, in order to simplify the optimization, the airfoil geometry is approximated by a parametrization, which enables to reduce the number of needed parameters to as few as possible, while effectively controlling the major aerodynamic features. The present work has been done on the Class-Shape function Transformation method (CST) [1, 2]. Also, the paper introduces the concept of Genetic Algorithm (GA) to optimize a NACA airfoil for specific conditions. A Matlab program has been developed to implement CS into the Global Optimization Toolkit. The pressure distribution lift and drag coefficients of the airfoil geometries have been calculated using two programs. The first one is an in-house code based on the Hess-Smith [3] panel technique and on the boundary layer integral equations, while the second is an XFOIL program. The optimized airfoil has improved aerodynamic characteristics as compared to the original one. The optimized airfoil is validated using the Ansys-Fluent commercial code.
Twisted Contact Structures in Turbulent Flows
Authors: DUMITRESCU Horia , CARDOS Vladimir , BOGATEANU Radu
Published: March 2019

The “hairpin” vortical structure initiated from a conceptual model of Theodorsen refers to a Ω-shaped vortex with two streamwise-oriented legs connected via a raised spanwise-oriented arch. Both computational and experimental studies in flow visualization revealed considerable disagreement as to the underlying hairpin vortex generation mechanism as well as its interpretation. The goal of this paper is to give a deeper insight of this key issue closely related to the turbulence as a dynamic stochastic phenomenon involving the origin and its generation mechanism. The topological concept of twisted contact structures associated with vorticity concentrations in wall-bounded flows strongly contorted at the starting-time is used to explain the genuine structured turbulence of Lagrangian nature at sufficiently large Reynolds numbers. The dynamical stochastic models of starting impact permit to identify two intrinsic scales for describing the starting impact-wall twist relationship generating a local turbulence mechanism. The inertia scale (rate of inertia, e) and circulation scale (azimuthal wave length, π) are measures for impact and twist, respectively, the turbulence lying in their dynamics like a torsion pendulum mechanism. The intrinsic scales of molecular nature have an interesting correspondence in macro-flow field through two relativistic well-known parameters: Mach number and Reynolds number playing the role of some reduced amplitudes and frequencies of the compressibility waves generated by the starting impact/shock. The maximum amplitude 2/3M∞= defines a critical Reynolds number 25200Re1/22/310/scraNm≡=⋅ρ (a0 –sound velocity of air at rest), numerically equal to the maximum impact pressure where the frictional shearing stress is near annulled, and its inverse value is the equilibrium kinematic viscosity 2201.510/ms−=⋅ν or the stable minimum circulation at a contact surface. These reference dimensional quantities are used to a more comprehensive definition of the current Reynolds numbers as the ratio of 20(/)V∞ν contact to (/)Vl∞ outer flow frequencies. Then, it is shown that the wave behavior of wall-bounded flows have a universal character (regardless of much diversity of flow cases) where the wall torsion pressure and the frictional wave drag are more realistic models than Lighthill’s boundary vorticity flux (BVF) mechanism and semi-empirical Prandtl’s wall law.
Metáfora y estructura conceptual
Authors: Castaño Castaño Emilia , Hilferty Joseph
Published: March 2019

La lingüística cognitiva siempre ha argumentado que la metáfora no pertenece exclusivamente al lenguaje, sino que es una competencia que se basa en la habilidad humana de concebir un dominio de experiencia en términos de otro. Entendida así, la metáfora no puede ser otra cosa que un fenómeno conceptual. No obstante, pocos adeptos de la lingüística cognitiva han concentrados sus esfuerzos en catalogar manifestaciones metafóricas en ámbitos no lingüísticos. En este trabajo, sugerimos que es factible encontrar pruebas de que la metáfora es un proceso conceptual y, como tal, se manifiesta en esferas que no son estrictamente lingüísticas. Para ello, aportamos un seguido de evidencias muy diversas, como por ejemplo su papel en el razonamiento lógico-matemático de los niños en la fase preoperacional del desarrollo cognitivo, la programación de interfaces para aplicaciones informáticas y los resultados de tres estudios empíricos realizados recientemente en el campo  de la psicología cognitiva que analizan los efectos whorfianos en la conceptualización del tiempo y los efectos del espacio en la memoria emocional.
La morfología flexiva en los verbos de la lengua de señas uruguaya
Authors: Fojo Denis Alejandro Damián
Published: March 2019

En el actual artículo se presentan los resultados de un análisis morfológico abocado a la flexión en los verbos de la lengua de señas uruguaya (LSU). El estudio discierne las características del proceso morfológico flexivo de la categoría gramatical señalada, definiendo y ordenando, de esta manera, a las diversas materializaciones de las unidades morfológicas mencionadas. Entre los puntos desarrollados se encuentran la flexión de persona, número, modo, tiempo y aspecto. Todos los signos morfológicos nombrados son abordados desde una perspectiva gramatical tradicional y, a su vez, se hace uso de descripciones fonológicas para lograr una crítica más precisa de las unidades de análisis propuestas.
Aplicació de rúbriques per a l’avaluació dels alumnes en el laboratori químic
Authors: Gonell Francisco , Gonell Sergio , Julián-López Beatriz , Mata Jose A.
Published: March 2019

El present treball de millora educativa constitueix un exemple de millora en les pràctiques de laboratori de l’assignatura QU0924 Química Inorgànica III mitjançant la introducció de rúbriques com a instrument d’avaluació. Clàssicament, l’avaluació en el laboratori químic es feia de manera subjectiva, és a dir, el professor tenia la intuïció de qui estava seguint i fent correctament les pràctiques. A més a més, la distribució dels grups de treball de laboratori per parelles feia més dificultosa l’avaluació individual dels estudiants, que en molts casos no sabien molt bé amb quins criteris se’ls avaluava.La introducció d’una rúbrica per a avaluar les distintes competències dels estudiants al laboratori químic ha permès sistematitzar l’avaluació d’aquesta assignatura desglossant-la en les parts més importants que s’han de tenir en compte a l’hora d’avaluar i aportant-li una major objectivitat. Aquest fet es reflecteix en una major confiança del professor a l’hora de realitzar l’avaluació. A més, els alumnes tenen molt més clars quins són els criteris que utilitzarà el professor quan avalua, donant-los la oportunitat de centrar-se en les coses importants.
Concept map: collaborative learning and inquiry-based learning
Authors: Nonell Rosa , Estruch Alejandro , González Aregall Marta
Published: March 2019

Aquest treball d'innovació docent s'ha dut a terme en el marc de l'assignatura "Política Econòmica d'Espanya i de la Unió Europea". El mètode emprat combina aprenentatge individual i aprenentatge col·laboratiu. Consta d'una sèrie de fases entre les quals podem destacar l'elaboració del mapa conceptual de l'assignatura. Aquesta activitat té una gran rellevància, ja que posa de manifest la quantitat i i la qualitat dels documents consultats, cosa que incideix positivament en la preparació de la prova de síntesi final i alhora acostuma els alumnes a indagar i fer una recerca exhaustiva que després posaran en comú amb els seus companys.
Avaluació online en grups grans: ACME a la Facultat d’Economia i Empresa de la UAB
Authors: Márquez Cebrián M. Dolores , Soriano Sáez Pilar
Published: March 2019

El nombre d’estudiants matriculats als primers cursos a la Facultat d’Economia i Empresa de la UAB és molt elevat, això dificulta el seu seguiment de forma individualitzada i continua. En les assignatures de Matemàtiques i Estadística és essencial que els alumnes realitzin un gran nombre d’exercicis per tal de poder assolir tant la destresa en el tractament de la informació, com l’adquisició dels conceptes. Per aquest motiu i per les funcionalitats que ofereix, es va decidir utilitzar ACME com plataforma d’aprenentatge.   L'ACME “Avaluació Continuada i Millora de l'Ensenyament” és una plataforma d’e-learning perfectament connectada amb Moodle i orientada a la correcció automàtica d'un gran ventall d'exercicis. En aquesta comunicació es presenten el procés i els resultats de la implantació d’ACME durant el curs 2014/15 en les assignatures de Matemàtiques I, d’una banda, i Estadística I i II d’altra banda. Els objectius que es perseguien en cada una de les assignatures han estat diferents, però en general es pot concloure que la plataforma és útil i està ben valorada pel professorat com a eina complementària en el procés d’avaluació.
Posicionamiento multivariante de las expectativas de estudiantes graduados, profesores y empresarios mediante componentes principales categóricos
Authors: Alcañiz Manuela , Claveria Oscar , Torra Porras Salvador
Published: March 2019

El presente artículo analiza las percepciones y las expectativas de los graduados universitarios, los profesores y los empresarios en cuanto a la adquisición de competencias desde una óptica multivariante. Para ello se comparan las competencias y habilidades desarrolladas durante los estudios universitarios (percepciones) y las que se les exigen a los estudiantes graduados para incorporarse al mercado laboral (expectativas). El estudio se basa en una encuesta realizada entre licenciados y académicos de la Universidad de Barcelona y empresarios catalanes. A partir del análisis estadístico efectuado, se detecta la existencia de un desajuste entre la percepción sobre las competencias desarrolladas y las expectativas sobre el nivel necesario para incorporarse en el mercado laboral. Se observa cómo las diferencias varían en función del colectivo analizado. A partir de los indicadores sintéticos creados se detecta que el mayor grado de discrepancia se da entre los empresarios para las diferentes competencias analizadas.
583. El negocio de la conservación ambiental: cómo la naturaleza se ha convertido en una nueva estrategia de acumulación capitalista en la zona andino-lacustre de Los Ríos, sur de Chile
Authors: De Matheus e Silva Luis Fernando , Zunino Hugo Marcelo , Huiliñir Curío Viviana
Published: March 2019

Actualmente, la “naturaleza” se ha convertido en una nueva estrategia de acumulación y determinados lugares han experimentado un proceso de resignificación, debido a sus características naturales y paisajísticas. Es el caso de la zona andino-lacustre de la región de Los Ríos, sur de Chile. Históricamente, esta zona (lar ancestral del pueblo mapuche) tenía como principal actividad la explotación  maderera, pero ahora el lugar se ve convertido en una nueva frontera para la expansión capitalista, sustentada por la ideología de la naturaleza “prístina”. Aquí discutimos una de las aristas de este proceso: la creación de grandes áreas de protección natural ligadas al capital, teniendo como referencia la reserva Huilo Huilo, con 100 mil hectáreas. Sugerimos que el establecimiento de este nuevo “latifundio verde” se origina en los mecanismos de acumulación por desposesión desatados con la neoliberalización de la economía chilena, generando una serie de consecuencias, como la apropiación privada de la naturaleza, la re-concentración fundiaria y el incremento de la especulación inmobiliaria.
590. Sostenibilidad del medio rural y patrimonio inmaterial: a propósito de los conocimientos tradicionales de las plantas
Authors: Gómez Pellón Eloy
Published: March 2019

El conocimiento de las propiedades de las plantas, y los usos asociados a las mismas con fines muy diversos, ha formado parte del bagaje tradicional de las poblaciones rurales y ha jugado un importante papel en la sostenibilidad ambiental, social y económica de las mismas. Existen sobradas pruebas de que se trata de un valioso patrimonio cultural, con un fuerte componente inmaterial, que corre el riesgo de perderse definitivamente. Los motivos se hallan en la presión ejercida por un poderoso cambio social, consecuente con un creciente fenómeno urbanizador y con una globalización amenazante para la existencia de las culturas locales. La imperiosa necesidad de proteger este patrimonio ha conducido a la adopción de medidas de muy diverso alcance que se repasan en el artículo.
The Son of God and Trinitarian Identity Statements
Authors: Owen Matthew , Dunne John Anthony
Published: March 2019

Classical Trinitarians claim that Jesus—the Son of God—is truly God and that there is only one God and the Father is God, the Spirit is God, and the Father, Son, and Spirit are distinct. However, if the identity statement that ‘the Son is God’ is understood in the sense of numerical identity, logical incoherence seems immanent. Yet, if the identity statement is understood according to an ‘is’ of predication then it lacks accuracy and permits polytheism. Therefore, we argue that there is another sense of ‘is’ needed in trinitarian discourse that will allow the Christian to avoid logical incoherence while still fully affirming all that is meant to be affirmed in the confession ‘Jesus is God.’ We suggest a sense of ‘is’ that meets this need.
Editorial: The Son of God
Authors: Owen Matthew , Sanders Fred
Published: March 2019

For as long as the Christian church has been working out its understanding of the second person of the Trinity, it has employed analytic philosophical reflection to sharpen theological comprehension. In recent times, there has been a rekindled appreciation for the employment of analytic reflection in the service of theology. Analytic theology has established itself as a way of doing theology that employs analytic philosophical analysis in the project of faith in divinely revealed truths seeking understanding. In this issue, the fresh insights of analytic theology are applied to a theme most central to Christian theology—the Son of God.
La colonisation valaque sur les versants nord des Carpates pendant le Petit Âge Glaciaire (aux XVe et XVIe siècles)
Authors: Jawor Grzegorz
Published: March 2019

Osadnictwo wołoskie na północnych stokach Karpatów podczas małej epoki lodowej (XV i XVI w.)W okresie od XV do XIX wieku w Karpatach miało miejsce znaczące pogorszenie klimatu. Jest to fragment zjawiska globalnego, przez przedstawicieli różnych nauk o ziemi zwane Małą Epoką Lodową (MEL). Rozważaniom zawartym w artykule towarzyszyło wstępne założenie, że te wydarzenia miały szczególny wpływ na warunki egzystencji społeczności zasiedlających na przestrzeni XV i XVI stulecia obszary położone w strefie podgórskiej i górskiej. Na tym obszarze znajdują się górne piętra zasięgu różnych roślin uprawnych, zwłaszcza kluczowych dla rolnictwa zbóż ozimych. Nawet niewielkie wahania wieloletnich średnich temperatur potrafią znacząco je podwyższać lub obniżać. Wnioski zawarte w pracy sformułowano w oparciu o informacje zawarte w źródłach przede wszystkim o charakterze skarbowym, do tej pory przez historyków klimatu niedoceniane. Analizę zachodzących w poszczególnych osadach zmian przeprowadzono z kolei posługując się metodyką stosowaną przez historyków osadnictwa. Efektem zaprezentowanych niżej badań jest generalny wniosek o istnieniu w analizowanym okresie powszechnego zjawiska narastania na obszarach karpackich elementów modelu gospodarczego funkcjonowania wsi opartego na hodowli. Odbywało się to kosztem ograniczania lub czasami nawet eliminowania zajęć rolniczych. Stanowiło to decydujący powód dla którego poszczególni wielcy właściciele ziemscy sprzyjali lub inicjowali kolonizację opartą na prawie wołoskim lub co najmniej na jego elementach. Z tej przyczyny zwłaszcza XVI wiek stał się okresem gwałtownego rozwoju tego nurtu osadniczego w rejonach karpackich. Miało to poważne konsekwencje nie tylko dla gospodarki. W pracy zwrócono uwagę, że wprowadzanie zmian mogło się odbyć poprzez migracje obcej etnicznie ludności-zaznajomionej z tajemnicami wyspecjalizowanej hodowli, niedostępnej klasycznym rolnikom. Wśród przybyszów pojawili się również etniczni Wołosi. Jedną z konsekwencji tych wędrówek było też znaczne rozszerzenie w Małopolsce zasięgu prawosławia kosztem katolicyzmu.
Wojciech Jóźwiak, Obraz początku i końca średniowiecznego państwa w bułgarskiej powieści historycznej z lat 1874-1989, Wydawnictwo Naukowe UAM, Poznań 2017, ss. 290.
Authors: Moroz-Grzelak Lilla Janina
Published: March 2019

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Stanisław Cieślak SJ, Ndre Mjeda dhe jezuitët e tjerë të Provincës së Venecies në Krakov, tłum. Leonard Zissi, (Ndre Mjeda i inni jezuici z prowincji weneckiej w Krakowie), Tirana 2018, ss. 192.
Authors: Czekalski Tadeusz
Published: March 2019

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Misja Sędziwoja z Szubina do Zadaru. Epizod z czasów bezkrólewia w Polsce 1382-1384
Authors: Wróbel Dariusz Adam
Published: March 2019

Artykuł dotyczy jednego z najbardziej tajemniczych i sensacyjnych epizodów z czasu bezkrólewia po śmierci Ludwika Andegaweńskiego. Wojewoda kaliski Sędziwój z Szubina pojechał na Węgry po królewnę Jadwigę przeznaczoną na tron polski, lecz nie zdołał zrealizować celu swojej misji. Został zatrzymany w Zadarze wraz ze swymi  towarzyszami, natomiast królowa Elżbieta Bośniaczka wysłała do Polski młodego Jana z Tarnowa, syna kasztelana sandomierskiego z zadaniem zajęcia zamku wawelskiego. Autor dowodzi, że wyjazd Sędziwoja z Krakowa, jego feralne spotkanie z królową Elżbietą w Zadarze i jego ucieczka do Polski miały miejsce w 1383 r. Ma to  zasadnicze wpływ na postrzeganie charakteru misji i jej znaczenia w kontekście relacji polsko-węgierskich w tym okresie.
Yugoslav diplomats during the interwar period
Authors: Micic Srdjan
Published: March 2019

The article deals with influence of the Serbian elite in the scope of the Yugoslav Foreign Service during 1918–1939. The influence of the elite circles was particularly prominent in the Yugoslav Army and in the Ministry of Foreign Affairs, as was the case in Serbia until 1918. As non-institutional factors had great influence on the work of state institutions, the first aim of this paper is to examine the main aspect for selection, career development and obstacles in the life of Yugoslav Diplomats, derived from the power struggle among elite circles. The second aim is to compare Serbian and Yugoslav experiences in order to establish similarities and differences in the characteristics of the pre-War and Interwar Diplomatic-Consular personnel. The analysis is based on Yugoslav archival materials, as well as on foreign published documents, memorial literature and relevant Yugoslav/Serbian and foreign historiography.
Pejzaż językowy jako nośnik dziedzictwa kulturowego, na przykładzie miasta Poznania
Authors: Koszko Marta
Published: March 2019

Pejzaż językowy jako nośnik dziedzictwa kulturowego, na przykładzie miasta Poznania
Oświecenie greckie
Authors: Chadzinikolau Ares
Published: March 2019

Oświecenie greckie
Recenzja apologetyczna publikacji wydziałowej pt. Scripta manent – res novae, przygotowanej na okoliczność 25-lecia istnienia Wydziału Neofilologii UAM (1988–2013)
Authors: Puppel Stanisław
Published: March 2019

Recenzja apologetyczna publikacji wydziałowej pt. Scripta manent – res novae, przygotowanej na okoliczność 25-lecia istnienia Wydziału Neofilologii UAM (1988–2013)
Constructing political other in the discourse of the Egyptian Arab Spring
Authors: Bogomolov Alexander
Published: March 2019

Constructing political other in the discourse of the Egyptian Arab Spring
Kochanek czarownicy. Semantyczna analiza XVII-wiecznych protokołów z przesłuchań osób posądzanych o czary w mieście Grünberg [Zielona Góra]
Authors: Dąbrowska-Burkhardt Jarochna
Published: March 2019

Kochanek czarownicy. Semantyczna analiza XVII-wiecznych protokołów z przesłuchań osób posądzanych o czary w mieście Grünberg [Zielona Góra]
Horrory tłumaczeniowe czy tłumacze z piekła rodem? Czyli kilka słów o efektywności komunikacji interlingwalnej
Authors: Matulewska Aleksandra
Published: March 2019

Horrory tłumaczeniowe czy tłumacze z piekła rodem? Czyli kilka słów o efektywności komunikacji interlingwalnej
Układ twarzy i gestosfery w kontekście konfliktu komunikacyjnego w komunikacji bezpośredniej
Authors: Puppel Joanna
Published: March 2019

Układ twarzy i gestosfery w kontekście konfliktu komunikacyjnego w komunikacjibezpośredniej
Kommunikation als basis des FSU: Sprache, Wissen, Kultur
Authors: Skowronek Barbara , Skowronek Alicja
Published: March 2019

Kommunikation als basis des FSU: Sprache, Wissen, Kultur
Universitetet i Agders røtter er 175 år i 2014 – Andreas Faye og Holt seminar
Authors: Jahr Ernst Håkon
Published: March 2019

The University of Agder changed status from a university college to a full-fledged university with all university privileges in 2007. However, the academic roots of the university go back to the year 1839, when the first teacher training college was established in Holt in Agder, close to the small town of Tvedestrand. This year (2014), then, the University of Agder can celebrate that the oldest studies at the university are 175 years old. This paper takes a closer look at the man who became the first rector of the college at Holt, the priest Andreas Faye (1802-69). Faye was an extremely active scholar and an important pioneer in several areas – folklore, history and education being perhaps the most important ones. This paper also shows how he, and more than his contemporary Norwegian colleagues, was engaged in an international network of researchers, especially in Denmark and Germany.
Barokowi trubadurzy czyli jak tłumaczyć średniowieczną poezję okcytańską na język polski
Authors: Loba Anna
Published: March 2019

Barokowi trubadurzy czyli jak tłumaczyć średniowieczną poezję okcytańską na język polski
Arman Begoyan’s cognitive-conceptual therapy: an overview and some techniques
Authors: Arakelyan Tatevik , Begoyan Arman
Published: March 2019

Arman Begoyan’s cognitive-conceptual therapy: an overview and some techniques
An eye for an eye and the struggle for power in the discourse of the Egyptian Arab Spring
Authors: Bogomolov Alexander
Published: March 2019

An eye for an eye and the struggle for power in the discourse of the Egyptian ArabSpring
The phenomenology of SPE boundaries
Authors: Haładewicz-Grzelak Małgorzata
Published: March 2019

The phenomenology of SPE boundaries
Dual voicing of Asian American writers: the case of Amy Tan
Authors: Lehman Iga Maria
Published: March 2019

Dual voicing of Asian American writers: the case of Amy Tan
Między eksplanacją a eksplikacją – przyczynek do metodologii lingwistyki. Uwagi na marginesie Historii humanistyki Rensa Boda
Authors: Zabrocki Władysław
Published: March 2019

Między eksplanacją a eksplikacją – przyczynek do metodologii lingwistyki. Uwagi na marginesie Historii humanistyki Rensa Boda
Wishes as bene- and malefactive speech acts. On the basis of discrediting parliamentary speeches in the Polish Lower House
Authors: Jurewicz Magdalena
Published: March 2019

What will be analysed in the paper, from the pragmalinguistic perspective, is the specificity and the positioning of wishes in an MP’s speech as a particular type of text. In my research, I would like to shed some light on the multifunctioning of such speech acts in the public performances, to which parliamentary speeches belong, which stems from the multitude of their addressees. I will be particularly interested in the change of the illocutionary force of wishes which, thanks to the influence of the irony that they contain, may serve the opposition politicians to mock the ruling party’s MPs. This, in turn, can indirectly lead to the disparagement of the latter. In a broader sense it can also be the result of a general persuasive function of all political speeches. The marking of irony is very specific for a given culture or even the idiolect of particular MPs. The precise knowledge of the possible indirect readings of some MPs’ utterances, and the techniques for deciphering ironic expressions would be very valuable for interpreters who have just recently begun their work in e.g. the European Parliament, where the speeches of MPs are interpreted simultaneously.
“I then for the first time felt fearful she might not rally…”: a discourse analysis of the nineteenth century case reports in ophthalmology
Authors: Zabielska Magdalena
Published: March 2019

The present paper constitutes a qualitative discursive investigation of the nineteenth century case reports from ophthalmology derived from a specialist American medical journal, and focuses on citation as well as on authorial and patient’s presence. Regarding the first aspect, the present study generally confirms the results of the previous research, i.e. significant subjectivity, directness and informal character of the texts at hand. However, it also provides another insight into the scholarly communication in the nineteenth century, focusing on how patients are positioned therein, which has not received significant attention in the literature of the subject. Additionally, the paper offers an overview of the studies on specific aspects of scientific prose of the nineteenth century, including the medical context, as well as attempts to show the relation between the texts analysed and the context of their production and functioning, following the tradition of Genre Rhetorical Studies.
The involvement of Polish teachers of English in teaching target language culture
Authors: Zybert Jerzy
Published: March 2019

The present paper discusses the current perception of the concept of culture with relation to FL students’ needs. It explores the extent to which Polish teachers of English are aware of the significance of teaching target culture and reports on its actual implementation in the language classroom. Comments on the present situation and suggestions for improving it are provided.
Wspomnienie o Profesorze Wolfgangu Vierecku (1937-2018)
Authors: Puppel Stanisław
Published: March 2019

Wspomnienie o Profesorze Wolfgangu Vierecku (1937-2018)
Modelling of the Response of Partially Saturated Non-cohesive Soil Subjected to Undrained Loading
Authors: Świdziński Waldemar , Mierczyński Jacek , Smyczyński Marcin
Published: March 2019

The paper deals with the modelling of the undrained response of non-cohesive partially saturated soils subjected to triaxial compression. The model proposed is based on an incremental equation describing the pre-failure response of non-cohesive soils during shearing. The original model, developed by Sawicki, was modified by taking into account pore fluid compressibility. The governing equation makes it possible to simulate effective stress paths under undrained conditions. Numerical results are compared with experimental data.
Economics of NHS Cost-Saving and its Morality on the ‘Living Dead’
Authors: Jackson Emerson Abraham
Published: March 2019

This article has been championed on account of the experience of (perceived) economic rationalization which seem to be the foremost of patients’ care as opposed to addressing distress to human existing well-being, while in a state of being tormented with agonizing news of prolonged ill health. Several considerations have been proposed as a way of addressing the need to rationalize resources in ensuring the long standing history of the NHS focus on ‘free health care’ is critically covered, but not in a way that destroys confidence on the ability of professionals to manifest ethical prudence in their acts of judgments about whether patients care is to be made immediate or prolonged on a waiting list. There is certainly serious impacts to be comprehended with in situation of economic rationality through services provided by the NHS; it is believed that tangible outcomes about definitive care for patients can be addressed collaboratively.
Kants Begriff der Vernunft
Authors: Marx Esther
Published: March 2019

The task of this article is to explore whether Kant developed his insights into reason on the basis of a pre-conceptual paradigm and to explain the functions assumed in this paradigm by metaphorical devices. As far as methods are concerned, the author refers to Lichtenberg’s ideas concerning paradigmatic cognition, but also to Blumenberg, who conceded important functions of orientation to pre-conceptual constructions of knowledge. Starting from the metaphor of a tree of knowledge, Kant develops a paradigm, which includes analogies with the natural sciences of the Modern era. Kant’s reasoning also refers to the paradigm of the courtroom hearing. The author considers that both paradigms are essential to the foundation of Kant’s concept of reason.
Mandibular osteomyelitis in the bottlenose dolphin Tursiops truncatus (Montagu, 1821) (Odontoceti: Cetacea): first case in the Mexican Caribbean
Authors: Niño-Torres Carlos Alberto , Castelblanco-Martínez Delma Nataly , Blanco-Parra María del Pilar , Sánchez Okrucky Roberto
Published: March 2019

Oral pathological conditions are common in mammals and have been relatively well documented for some wild groups, but are rarely reported in marine mammals. Here, we report for the Mexican Caribbean the first case of mandibular osteomyelitis in a free-ranging dolphin. A bottlenose dolphin Tursiops truncatus adult male (256.5 cm total length) was found stranded dead in the west coast of the State Reserve “Chetumal Bay Manatee Sanctuary”. Herein, we discuss some plausible explanations about the origin of this lesion to improve the knowledge about the species biology.
Failing States, Human (In)Security, and the American World Novel
Authors: Watson David
Published: March 2019

As a growing number of contemporary American novelists take the world and its socio-cultural and geopolitical complexity as their subject matter, the contemporary novel’s form and sense of worldliness are shifting. Twenty-first century US fiction challenges normative models of the world proposed by theories of cosmopolitan relationality by projecting fragile worlds of strife and trauma, in which violence accompanies geopolitical turbulence. In these novels, discourses around human security—the everyday security needs of vulnerable populations—are increasingly prominent. Accordingly, contemporary US fiction often incorporates within its geopolitical imaginary such issues as human rights, humanitarian interventions, development, and how life is disabled by prejudice, civil war, scarcity, and health or other crises. In this essay, I range across a number of works by contemporary American novelists such as Dave Eggers, Jennifer Egan, Denis Johnson, Dana Spiotta, and Bob Shacochis in which state failures as well as human and geopolitical security concerns impact on the form given to the world by these novelists. In their novels, narratives concerning human security as well as threats to geopolitical stability produce transnational geographies in which global interconnections and circulation intensify feelings of insecurity.
Adaptive Design for Educational Hypermedia Environments and Bio-Educational Adaptive Design for 3D Virtual Learning Environments
Authors: Santoianni Flavia , Ciasullo Alessandro
Published: March 2019

Adaptive learning environments design has been originally influenced by the adaptive learning environments model, which has been recently re-shaped by the bio-educational adaptive approach. Adaptive and bio-educational models share the common main idea that education should be adaptive. Since the 90’s the adoption of an adaptive educational point of view have been at the base of adaptive educational hypermedia systems, which design joins interest towards learners’ individual differences with adaptive learning environments research. Educational hypermedia systems have been overcome by the technology of 3D Virtual Learning Environments. Some emerging questions are related to the design criteria of adaptive learning environments. Which lessons learned from adaptive hypermedia systems design could be now applied to VLEs’ design? How a virtual learning environment should be designed to be adaptive? This research tries to answer to these questions by describing Federico 3DSU, an educational University 3D Virtual Learning Environment which has been designed with adaptive criteria, according to bio-educational model
Self-quotations and politeness: The construction of discourse events and its pragmatic implications
Authors: Cohen-Achdut Miri
Published: March 2019

The article discusses self-quotations as a strategy of politeness. I maintain that self-quotations fulfill strategies of linguistic politeness, and that the fulfillment of these strategies must be understood through the discourse event standing in the background of the self-quotation. In the corpus – 13 Hebrew articles written by women in eastern Europe in the nineteenth century – 35 self-quotations were found. All of them are “fictional”, i.e. they do not refer to an actual discourse event that occurred in the past. Nevertheless, the fictionality is not identical in all the cases examined, and it arises from the specific characteristics of each case. The examination of the construction of the other discourse event (past, future, or fictional) reveals that it strongly influences the quotation’s pragmatic function, and specifically its “polite” character. The discourse event might be a speech or thought event; it might actually have occurred in the past or only be implied by a future tense or a conditional structure; or sometimes it may be openly declared as a discourse event that will not take place altogether. Self-quotations function as hedging devices, qualifying various aspects of the utterance – its illocutionary force, comprehensiveness, the degree of social authority it expresses, or the act of uttering itself.
Effects of cellular energy homeostasis modulation through AMPK on regulation of protein translation and response to hypoxia
Authors: Gunaydin Gurcan , Gedik Mustafa Emre
Published: March 2019

Objective

AMP-activated-protein-kinase (AMPK) regulates cellular energy-homeostasis. Eukaryotic-elongation-factor-2-kinase (eEF2K) plays important roles in regulating protein-synthesis, functions similarly to AMPK to protect cancer-cells from metabolic stress. Tumor-hypoxia induces angiogenesis with activation of hypoxia-inducible-factor-1-alpha (HIF-1α). AMPK might be implicated both in regulation of protein-translation and response-to-hypoxia. We aimed to investigate the effects of AMPK modulation on regulation of protein translation and response-to-hypoxia by evaluating eEF2K and HIF-1α proteins in breast and hepatocellular cancers.

Materials and methods

Hepatocellular (Huh-7, HepG2) and breast (SKBR-3, MDA-MB-453) cancer-cells were incubated with AMPK-activator (A769662) or inhibitor (dorsomorphin) for 8/24 h. Alterations in eEF2K/HIF-1α protein expressions were examined.

Results

Cancer-cells slightly increased eEF2K expression after 24-h of AMPK-activation. Significant decreases in eEF2K expressions were observed with AMPK inhibition in all cancer-cells except Huh-7. Slight transient decrease in HIF-1α expression was observed after 8-h of AMPK-activation in all cancer-cells except MDA-MB-453. AMPK-inhibition decreased HIF-1α expression, especially in HepG2-cells.

Conclusion

The effects of AMPK modulation on eEF2K/HIF-1α protein expressions were investigated. Cells with varying molecular-expression-profiles demonstrate different metabolic activities. AMPK-activation may provide adaptive advantage to cancers and such an advantage may be reverted with an AMPK-inhibitor. The current study contributes to the literature in determining the effects of therapeutic strategies targeting AMPK on cancer-cell metabolic-pathway regulation.
Investigation of beta globin gene mutations in Syrian refugee patients with thalassemia major
Authors: Çevirici Hatice , Acıpayam Can , Yenilmez Ebru Dündar , Belen Fatma Burcu , Pekpak Esra , Yaman Yöntem , Tuli Abdullah
Published: March 2019

Objectives

This study, detection of beta globin gene mutations in thalassemia major patients who migrated from Syria to Kahramanmaraş region were planned.

Materials and methods

The study included 35 Syrian national beta thalassemia major patients. Beta globin gene mutations were detected by ARMS (Amplification Refractory Mutation System) method, RFLP (Restriction Fragment Length Polymorphism) method and DNA sequence analysis. Codon 15, codon 9/10, codon 5 and codon 8 mutations, which we could not detect with other methods in our study, were detected by sequence analysis.

Results

In beta thalassemia major patients, 16 types of mutations were detected, the most common being IVS-I-110 (n=8). Other mutations are according to frequency order IVS-II-745 (n=3), codon 44 (n=3), codon 15 (n=3), IVS-I-110/IVS-I-1 (n=3), codon 5 (n=2), IVS-I-1 (n=2), codon 8/IVS-II-1 (n=2), codon 44/codon 15 (n=2), IVS-II-1 (n=1), codon 39 (n=1), IVS-I-6/codon 5 (n=1), codon 9/10 (n=1), IVS-I-110/codon 39 (n=1), IVS-I-5/IVS-II-1 (n=1), codon 39/IVS-II-745 (n=1).

Conclusions

According to the results of our study beta-thalassemia mutations in Syrian immigrant groups show heterogeneity and mutation types of mutation map is similar to Turkey. The conclusion is to prevent families to have a second patient child by genetic counseling.
Exploring the Effect of Electron Withdrawing Groups on Optoelectronic Properties of Pyrazole Derivatives as Efficient Donor and Acceptor Materials for Photovoltaic Devices
Authors: Irfan Ahmad , Pannipara Mehboobali , Al-Sehemi Abdullah G. , Mumtaz Muhammad Waseem , Assiri Mohammed A. , Chaudhry Aijaz Rasool , Muhammad Shabbir
Published: March 2019

Multifunctional pyrazole derivative, i.e. 3-amino-1-(5-hydroxy-3-methyl-1H-pyrazol-4-yl)-1H-benzo[f]chromene-2-carbonitrile (PBCC) has been synthesized and characterized. To shed light on various properties of interests, the ground state geometry was optimized by adopting Density Functional Theory (PBE/TZ2P). The effect of different functionals on the absorption wavelengths was studied by using Time-Domain DFT (TDDFT), e.g. GGA functional PBE, hybrid functionals B3LYP and PBE0, rang separated functionals CAM-B3LYP, LCY-PBE and CAMY-B3LYP, Dispersion Corrections PBE-D3 and B3LYP-D3. Among all these functionals PBE and PBE-D3 were found to be good choices which reproduced the absorption spectra of the PBCC. With the aim to enhance the electro-optical, charge transfer and photovoltaic properties, five new derivatives were designed by di-substituting the –F, –Cl, –Br, –COOH and –CN at benzochromene moiety. The electron injection barrier, band gap alignment and related calculated photovoltaic parameters revealed that PBCC and its newly designed derivatives would be proficient to be used in photovoltaic devices. These compounds can be used as donor materials in dye-sensitized solar cells (DSSCs) with favorable type-II band alignment. Moreover, PBCC and most of its derivatives might also be good choice as efficient acceptors with poly(dithieno[3,2-b:2,3-d]pyrrole thiophene) (PDTPr-T) and donor materials with Phenyl-C61-butyric acid methyl ester (PC61BM) in organic solar cells.
GIRK Channel Activity in Dopamine Neurons of the Ventral Tegmental Area Bidirectionally Regulates Behavioral Sensitivity to Cocaine
Authors: McCall Nora M. , Marron Fernandez de Velasco Ezequiel , Wickman Kevin
Published: March 2019

Dopamine (DA) neurons of the VTA have been widely implicated in the cellular and behavioral responses to drugs of abuse. Inhibitory G protein signaling mediated by GABABreceptors (GABABRs) and D2DA receptors (D2Rs) regulates the excitability of VTA DA neurons, DA neurotransmission, and behaviors modulated by DA. Most of the somatodendritic inhibitory effect of GABABR and D2R activation on DA neurons reflects the activation of G protein-gated inwardly rectifying K+(GIRK) channels. Furthermore, GIRK-dependent signaling in VTA DA neurons can be weakened by exposure to psychostimulants and strengthened by phasic DA neuron firing. The objective of this study was to determine how the strength of GIRK channel activity in VTA DA neurons influences sensitivity to cocaine. We used a Cre-dependent viral strategy to overexpress the individual GIRK channel subunits in VTA DA neurons of male and female adult mice, leading to enhancement (GIRK2) or suppression (GIRK3) of GIRK channel activity. Overexpression of GIRK3 decreased somatodendritic GABABR- and D2R-dependent signaling and increased cocaine-induced locomotor activity, whereas overexpression of GIRK2 increased GABABR-dependent signaling and decreased cocaine-induced locomotion. Neither manipulation impacted anxiety- or depression-related behavior, despite the link between such behaviors and DA signaling. Together, these data show that behavioral sensitivity to cocaine in mice is inversely proportional to the strength of GIRK channel activity in VTA DA neurons and suggest that direct activators of the unique VTA DA neuron GIRK channel subtype (GIRK2/GIRK3 heteromer) could represent a promising therapeutic target for treatment of addiction.

SIGNIFICANCE STATEMENTInhibitory G protein signaling in dopamine (DA) neurons, including that mediated by G protein-gated inwardly rectifying K+(GIRK) channels, has been implicated in behavioral sensitivity to cocaine. Here, we used a viral approach to bidirectionally manipulate GIRK channel activity in DA neurons of the VTA. We found that decreasing GIRK channel activity in VTA DA neurons increased behavioral sensitivity to cocaine, whereas increasing GIRK channel activity decreased behavioral sensitivity to cocaine. These manipulations did not alter anxiety- or depression-related behaviors. These data highlight the unique GIRK channel subtype in VTA DA neurons as a possible therapeutic target for addiction.
A case of pembrolizumab-induced severe DKA and hypothyroidism in a patient with metastatic melanoma
Authors: Hakami Osamah A , Ioana Julia , Ahmad Shahzad , Tun Tommy Kyaw , Sreenan Seamus , McDermott John H
Published: March 2019

Immune checkpoint inhibitors (ICIs) have revolutionised cancer therapy and improved outcomes for patients with advanced disease. Pembrolizumab, a monoclonal antibody that acts as a programmed cell death 1 (PD-1(PDCD1)) inhibitor, has been approved for the treatment of advanced melanoma and other solid tumours. Immune-related adverse events (irAEs) including endocrinopathies have been well described with this and other PD-1 inhibitors. While hypothyroidism and hyperthyroidism, and less commonly hypophysitis, are the most common endocrinopathies occurring in patients treated with pembrolizumab, the incidence of type 1 diabetes mellitus (T1DM) was low in clinical trials. We report a case of pembrolizumab-induced primary hypothyroidism and T1DM presenting with severe diabetic ketoacidosis (DKA). A 52-year-old male patient was treated with pembrolizumab for metastatic melanoma. He presented to the emergency department with a 1-day history of nausea and vomiting 2 weeks after his seventh dose of pembrolizumab, having complained of polyuria and polydipsia for 2 months before presentation. He had been diagnosed with thyroid peroxidase (TPO) antibody-negative hypothyroidism, requiring thyroxine replacement, shortly after his fifth dose. Testing revealed a severe DKA (pH: 6.99, glucose: 38.6 mmol/L, capillary ketones: 4.9 and anion gap: 34.7). He was treated in the intensive care unit as per the institutional protocol, and subsequently transitioned to subcutaneous basal-bolus insulin. After his diabetes and thyroid stabilised, pembrolizumab was recommenced to treat his advanced melanoma given his excellent response. This case highlights the importance of blood glucose monitoring as an integral part of cancer treatment protocols composed of pembrolizumab and other ICIs.

Learning points:

The incidence of T1DM with pembrolizumab treatment is being increasingly recognised and reported, and DKA is a common initial presentation.

Physicians should counsel patients about this potential irAE and educate them about the symptoms of hyperglycaemia and DKA.

The ESMO guidelines recommend regular monitoring of blood glucose in patients treated with ICIs, a recommendation needs to be incorporated into cancer treatment protocols for pembrolizumab and other ICIs in order to detect hyperglycaemia early and prevent DKA.