bluuebunny/crossref_metadata_2025 huggingface dataset:
Common Polymorphisms in IFI16 and AIM2 Genes Are Associated With Periodontal Disease
Authors: Marchesan Julie T. , Jiao Yizu , Moss Kevin , Divaris Kimon , Seaman William , Webster‐Cyriaque Jennifer , Zhang Shaoping , Yu Ning , Song Catharine , Bencharit Sompop , Teles Ricardo , Offenbacher Steven
Published: April 2017

Background: The single nucleotide polymorphism (SNP) context of a previously identified periodontitis‐associated locus is investigated, and its association with microbial, biologic, and periodontal disease clinical parameters is examined.

Methods: A 200‐kb spanning region of 1q12 previously highlighted in a genome‐wide association scan among 4,766 European American individuals (SNP rs1633266) was annotated. Two haplotype blocks were selected. Association of these polymorphisms with data on microbial plaque composition, gingival crevicular fluid (GCF)–interleukin (IL)‐1β levels, and clinical parameters of periodontal disease were examined. Descriptive analysis of IFI16 and AIM2 protein expression in gingival tissues from healthy individuals (n = 2) and individuals with chronic periodontitis (n = 2) was done via immunohistochemistry.

Results: The highlighted locus is a 100‐kb region containing the interferon γ‐inducible protein 16 (IFI16) and absent in melanoma 2 (AIM2) genes. Two haplotype blocks, rs6940 and rs1057028, were significantly associated with increased extent bleeding on probing and levels of microorganisms Porphyromonas gingivalis, Tannerella forsythia, and Campylobacter rectus (P ≤0.05). Haplotype block rs1057028 was also significantly associated with pathogens Fusobacterium nucleatum and Aggregatibacter actinomycetemcomitans, increased GCF–IL‐1β levels, and extent of probing depth ≥4 mm (P ≤0.05). Prevalence of severe periodontitis (biofilm‐gingival interface P3 classification) was positively associated with haplotype block rs1057028. Similar trends were observed for haplotype block rs1057028. IFI16 and AIM2 protein expression was observed in multiple cell types of gingival tissues, including inflammatory cells.

Conclusion: This study found IFI16 and AIM2 SNPs associated with higher levels of periodontal microorganisms and an increased percentage of periodontal disease clinical parameters, suggesting the need for functional studies and additional fine‐mapping of variants in the 1q12‐locus.
Carvacrol Ameliorates Ligation‐Induced Periodontitis in Rats
Authors: Kuo Po‐Jan , Hung Tsung‐Fu , Lin Chi‐Yu , Hsiao Hsiang‐Yin , Fu Min‐Wen , Hong Po‐Da , Chiu Hsien‐Chung , Fu Earl
Published: April 2017

Background: This study aims to evaluate the ameliorative effect of carvacrol, an anti‐inflammatory monoterpenoid phenol and a major component of Plectranthus amboinicus, on periodontal damage in an experimental rat model of periodontitis.

Methods: Forty Sprague‐Dawley rats were divided into ligation (Lig), non‐ligation (n‐Lig), and two ligation plus carvacrol (Lig+C) groups. Carvacrol (17.5 or 35.0 mg/kg body weight/day) was administered intragastrically from 1 day before ligation. On day 8, dental alveolar bone loss and gingival inflammation in periodontal specimens were examined by dental radiography, microcomputed tomography, and histology. Expressions of tumor necrosis factor‐α, interleukin (IL)‐1β, IL‐6, and inducible nitric oxide synthase messenger (m)RNAs, and levels of matrix metalloproteinase (MMP)‐2 and MMP‐9 in gingiva were examined by reverse transcription‐polymerase chain reaction and zymography.

Results: Dental radiography revealed periodontal bone‐supporting ratios in Lig and Lig+C groups were lower than the n‐Lig group, with Lig group ratios being lowest. Compared with the n‐Lig group, the cemento‐enamel junction–bone distance was significantly longer in Lig and Lig+C groups, with Lig+C groups showing shorter distances regardless of radiographic methods used. Histology and histometry showed less inflammatory area and stronger connective tissue attachment in Lig+C groups than in the Lig group. Cytokine/mediator mRNA expression and MMP‐9 levels were reduced in the Lig+C groups.

Conclusions: Carvacrol reduced tissue damage and bone loss caused by ligation‐induced periodontitis. The present results indicate that carvacrol might reduce tissue destruction by downregulating expression of proinflammatory mediators and MMP‐9.
À guisa de introdução
Authors: Soares Marília Lopes da Costa Facó
Published: April 2017

Durante o Simpósio, foram apresentados trinta e quatro trabalhos, tendo sido focalizadas, entre outras, as línguas Akroá, Bakairí, Chiquitano, Kamaiurá, Karajá, Karitiana, Kuripako, Lacandón del Sur, Mazahua, Mocoví, Shirian, Tenetehára, Tesapé, Ticuna (Tikuna), Wapixána, Xakriabá, Xavante, Yanomami, Yaqui, Yavarana, Yucateco – pertencentes a diferentes famílias linguísticas e relacionadas a diferentes pontos das Américas...
Construcciones causativas y anticausativas en Mocoví
Authors: Carrió Cintia Valeria
Published: April 2017

En este trabajo se analizan diferentes formas de expresar la semántica causativa y anticausativa en la lengua Mocoví. Se entiende a la causatividad como un universal semántico en cuya instanciación intervienen procesos gramaticales diversos. Se determina que la lengua presenta alternancia causativa en la que la forma incoativa es básica. Se estudian casos de verbos léxicamente causativos (causativos léxicos). Se distinguen dos morfemas que permiten marcar morfológicamente la causación (causativos morfológicos) y se revisan los casos de las nominalizaciones resultativa y de instrumento. Por último se estudian dos construcciones causativas analíticas. En todos los casos se hace referencia a la semántica de cada construcción, las bases que seleccionan las derivaciones y los contextos morfosintácticos y semánticos que condicionan su formación.
A Bayesian Phylogenetic Classification of Tupí-Guaraní
Authors: Michael Lev , Chousou-Polydouri Natalia , Bartolomei Keith , Donnelly Erin , Meira Sérgio , Wauters Vivian , O'Hagan Zachary
Published: April 2017

This paper presents an internal classification of Tupí-Guaraní based on lexical data from 30 Tupí-Guaraní languages and 2 non-Tupí-Guaraní Tupian languages, Awetí and Mawé. A Bayesian phylogenetic analysis using a generalized binary cognate gain and loss model was carried out on a character table based on the binary coding of cognate sets, which were formed with attention to semantic shift. The classification shows greater internal structure than previous ones, but is congruent with them in several ways.
Koropó, puri, kamakã e outras línguas do Leste Brasileiro
Authors: Ramirez Henri , Vegini Valdir , França Maria Cristina Victorino de
Published: April 2017

Neste estudo, realizamos uma análise aprofundada de línguas extintas localizadas no Leste do Brasil (de São Paulo a Salvador). Tradicionalmente, agrupa-se o koropó com o puri (coroado) e ambos na superfamília macro-jê. Inicialmente, refutamos qualquer afinidade entre as línguas koropó e puri e, subsequentemente, apresentamos razões para excluir o puri-coroado das línguas macro-jê. Prosseguindo em direção ao norte, examinamos detalhadamente a família maxakali, propomos uma classificação provisória de suas línguas afiliadas e comparamos pormenorizadamente essa família com línguas do seu entorno geográfico (kamakã, jê e krenak). Desse estudo, podemos concluir que o maxakali mantém estreita relação com o kamakã, sugerindo-nos a existência de um vínculo genético entre esses dois grupos linguísticos. Contudo, não podemos propor relação genética semelhante para todas as quatro famílias (maxakali, kamakã, jê, krenak) visto que seus falantes viviam numa área onde houve um longo período de contatos interétnicos que poderia ter favorecido o compartilhamento de grande número de empréstimos linguísticos entre esses idiomas.
Predicative possession in Nivacle
Authors: Fabre Alain
Published: April 2017

In this paper, I identify and analyse fourteen predicative possession strategies employed by speakers of Nivacle, a Mataguayo language from the Paraguayan Chaco. It is intriguing that all of these strategies but three are in common use among the speakers. Because quantifiers and numbers surface as verbs in Nivacle, these can be used as possessive predicates, which appears to be another typological rarity. The paper also includes a brief overview of predicative possession in the other three languages of the Mataguayo family.
Numerals in Juruna
Authors: Fargetti Cristina Martins , Sumaio Priscilla Alyne
Published: April 2017

Apresentamos uma reanálise dos numerais da língua juruna, trazendo dados novos em relação ao trabalho anterior (Fargetti 2007), também comparados a dados de registros escritos anteriores da língua. Discutimos brevemente o conhecimento atual sobre sistemas numéricos de línguas indígenas brasileiras, os fatores que levariam a sua grande diferenciação, e as possibilidades conhecidas de expansões.
Seki, Lucy(2010). Jene Ramŷjwena juru pytsaret
Authors: Chavarria Maria C.
Published: April 2017

Los Kamaiurá es un pueblo originario del Alto Xingú, en Brasil. A semejanza de muchos pueblos indígenas de América, su territorio se ha ido formando a lo largo de una historia trágica, pues han sido expulsados de sus territorios en varias oportunidades y fueron objeto del trabajo misional como muchas otras etnias, hasta ubicarse en lo que hoy es el Alto Xingú. Ellos pertenecen a la familia Tupi-Guaraní, del Tronco Tupí. Su lengua es una de las 180 habladas en Brasil. Se agrupan en cuatro parcialidades o clanes. Los nombres de sus territorios han sido documentados a través de narrativas míticas como las que aparecen en este libro...
Research on Foreign Ownership Applied in R&D Investment of Chinese GEM Companies
Authors: Wang Ying
Published: April 2017

This paper is to explore that if foreign ownership exactly affects on R&D investment of Chinese GEM companies. We use six variables, including RDS (the ratio of R&D and operating income), the proportion of foreign ownership, company size (the logarithm of total assets), gearing ratio, the proportion of the top five shareholders, and the location, to construct the regression model to verify the impact of foreign ownership on R&D investment for 153 listed firm sample during 2009-2014, which has removed companies without R&D investment. We find that foreign ownership and enterprise R&D investment indeed exists positive correlation, but not significantly; further investigation found that foreign ownership will not improve enterprise performance when it promotes R&D investment, but exist a negative correlation relationship. Therefore, such a relationship is important for company to control the proportion of foreign ownership to manage the ownership structure.
The association of the IL-1β-31 polymorphism and the development of neuroinfections
Authors: Biesiada Grażyna , Czepiel Jacek , Piątek Anna , Birczyńska Malwina , Żurańska Justyna , Wołkow Paweł , Perucki William , Jędrychowski Michał , Garlicki Aleskander
Published: April 2017

Introduction. Inflammation of the meninges can have various clinical courses, from mild, self‑limiting in some viral neuroinfections to severe, sometimes ending in death. The pro‑inflammatory cascade and defects in the inhibitors of the inflammatory response play an important prognostic role. Single nucleotide polymorphisms (SNPs) of the genes encoding cytokines, influence the severity of the inflammatory response.Aim. The aim of this study was to evaluate the effect of selected polymorphisms of proinflammatory cytokines IL-1β, TNF‑α and IL-8 on the development of neuroinfections.Material and Methods. We evaluated the laboratory results of 30 patients treated for bacterial and viral meningitis and compared those to 30 healthy volunteers. The following 4 variants were analyzed for occurrence of genetic polymorphism in patients with meningitis versus the control group: IL-1β 3953, IL-1β -31, TNF‑α -308, and IL-8 781. Then, we assessed the association between these genetic polymorphisms and the inflammatory response during the course of meningitis.Results and Conclusions. We observed that polymorphism of the IL-1β-31 significantly differs between patients and healthy subjects, the IL-1β -31AA polymorphism existed only in healthy individuals (p < 0.001). The WBC count was dependent on the TNF‑α -308 polymorphism with a statistically significant difference (p = 0.021) occurring among persons with variants AA and AG. In conclusion the study showed that the presence of the AA genotype of IL-1β-31polymorphism may have a protective effect on the development of meningitis. This polymorphism was not observed in any patient with meningitis.
Ischemia‑modified albumin in migraine patients during interictal period
Authors: Michalak Slawomir , Osztynowicz Krystyna , Płóciniczak Alicja , Myszka Waldemar , Nowicki Marcin , Węgrzyn Danuta , Drzewiecka Małgorzata , Kapecka Kinga , Kozubski Wojciech
Published: April 2017

Aim. Ischemia‑modified albumin (IMA) is a marker of myocardial ischemia and may be affected by ischemia occurring in other tissues. Migraine has been reported as a risk factor of ischemic stroke or cardiovascular events. Dysfunction of endothelial cells, as well as association with arteriopathies was evidenced in migraine patients. The aim of this study was to evaluate interictal IMA in migraine patients.Material and Methods. Fifty migraineurs aged 38 ± 9 years were included in the study. The control group consisted of 25 healthy volunteers aged 37 ± 8 years. In all subjects neurological examination was carried on, as well as clinimetric evaluation with the use of: MIDAS, MIGSEV, QVM, VAS and VRS. Ischemia‑modified albumin was evaluated by means of spectrophotometric method with the use of cobalt chloride. The concentrations of total cholesterol, HDL- and LDL‑cholesterol, triglycerides, homocysteine, C‑reactive protein and Lp(a) were analyzed with routine spectrophotometric methods.Results. IMA was significantly (P = 0.0108) higher in migraine patients (0.101; 0.00–0.327 O.D.) than in controls (0.00; 0.00–0.102 O.D.; median; interquartile range). Migraineurs with aura have also higher IMA than controls. IMA correlated (rS = 0.383, P = 0.0073) with VAS and with homocysteine concentration (rS = 0.430, P = 0.0026). Multiple regression analysis of IMA and atherosclerosis risk factors showed significant correlation (P = 0.0247) with HDL cholesterol (R = 0.2958) and triglycerides concentrations (R = 0.3285).Conclusions. IMA formation in migraine patients, as a marker of oxidative stress even during interictal period in patients with hyperhomocysteinemia and/or hypertriacylglyceridemia can reflect a milieu of factors which further increases the risk for cardiovascular complications.
Perspectives for gallotannins neuroprotective potential - current experimental evidences
Authors: Kujawski Radosław , Kujawska Małgorzata , Ożarowski Marcin , Baraniak Justyna , Laskowska Halina , Nowocień Tamara , Borowska Magdalena , Szulc Michał , Sobczak Agnieszka , Mikołajczak Przemysław
Published: April 2017

Gallotannins are class of hydrolyzable tannins consisting of gallic acid and a sugar moiety. Currently, there is growing interest around a possible neuroprotective effect of this class of phytochemicals, which is suggested to be a result of their active metabolites. Evidence from experimental studies has suggested that tannin‑rich plant preparations might be effective at reversing neurodegenerative pathology and age‑related declines in neurocognitive performance. This mini‑review summarizes, based on experimental studies, current knowledge about diverse neuroprotective abilities of gallotannins, mostly via antioxidant properties and some mechanisms of the effect are proposed including blocking accumulation of nitrites, inhibiting expression and activity of heme oxygenase 1(HO-1), and decreasing degradation of poly(ADP‑ribose) glycohydrolase (PARP).
A study of ofloxacin and levofloxacin photostability in aqueous solutions
Authors: Frąckowiak Anita , Kamiński Bartosz , Urbaniak Bartosz , Dereziński Paweł , Klupczyńska Agnieszka , Darul‑Duszkiewicz Monika , Kokot Zenon J.
Published: April 2017

Introduction. The photostability is one of the most important properties of drugs. A comprehensive study of ofloxacin (OFX) and levofloxacin (LVX) photostability in aqueous solutions was performed. Ofloxacin is a chemotherapeutic agent belonging to the second generation fluoroquinolones and is a racemate of (R)-(+)-ofloxacin and (S)-(-)-ofloxacin (LVX).Material and Methods. Samples of OFX and LVX were subjected to stress conditions of UV irradiation using a mercury‑vapor lamp. The study involved development of enantioselective high‑performance liquid chromatography (HPLC) and high‑performance capillary electrophoresis (HPCE) methods for separation of OFX enantiomers and their degradation products. These methods were used to monitor the degradation process of OFX and LVX under irradiation and to determine the kinetics of degradation of these antibacterial agents. Moreover, the identification of photoproducts was also attempted. The structure of the main photoproducts was examined by mass spectrometry (MS).Results and Conclusions. Using HPLC method it was possible to observe two products of OFX degradation and only one for LVX, while using HPCE method eight products of OFX degradation and six of LVX were observed. Some of the photoproducts retain character of optically active compounds. The trend of the photodegradation of both tested compounds was described by autocatalytic reaction proceeding according to the Prout‑Tompkins model. Some of the products of the decomposition catalyze this reaction. The rate of degradation was similar for both enantiomers but t0.5 was slightly longer for LVX than OFX. Based on MS experiments the photodegradation products of the studied fluoroquinolones and possible pathways of UV induced decay were identified.
Proteomic and metabolomic strategy of searching for biomarkers of genital cancer diseases using mass spectrometry methods
Authors: Matysiak Jan , Dereziński Paweł , Klupczyńska Agnieszka , Hajduk Joanna , Światły Agata , Plewa Szymon , Horała Agnieszka , Jaźwiński Patryk , Banach Paulina , Nowak-Markwitz Ewa , Kokot Zenon J.
Published: April 2017

The project entitled ”Proteomic and metabolomic strategy of searching for biomarkers of genital cancer diseases using mass spectrometry methods” is a study based on novel omics techniques. The main assumption of this research is the development of innovative model of searching of biomarkers in ovarian and prostate cancers using proteomics and metabolomics methodologies supported by bioinformatics analysis. The innovatory strategy based on the latest achievements in the field of mass spectrometry will allow for the implementation of the unique studies for discovery new biomarkers, which are useful in prediction, diagnosis and treatment of the genital cancers. To date, there is no comprehensive data including set of proteins and other endogenous compounds involved in the development and differentiation of these diseases. Therefore, the proposed approach may contribute to the discovery of biomarkers with high sensitivity and specificity, which will provide new information about genital cancers characterization.
Impact of sex and body mass index on cecal intubation time. Is it a myth that colonoscopy is easier to perform in obese than lean people?
Authors: Poniewierka Elżbieta , Dudkowiak Robert , Marczyński Witold
Published: April 2017

Introduction. Colonoscopy is the gold standard for prevention and early diagnosis of colorectal cancer. Procedure quality is an important issue. Current quality indicators, such as cecal intubation rate, adenoma detection rate, and withdrawal time, are important, but cecum intubation time influences all of them. Factors that determine cecal intubation time (CIT) include body mass index (BMI), age, sex, history of abdominal surgery, quality of bowel preparation, and visceral adipose tissue. Among those who perform colonoscopy, it is believed that the procedure is easier to perform in obese people. Aim. To determine whether cecal intubation time depends on body mass index and sex of patients undergoing colonoscopy.Material and Methods. An analysis of the technical aspects of colonoscopy, such as the time required to intubate the cecum, with respect to BMI and sex in 100 patients.Results. The average time taken to reach the cecum or ileum was slightly longer in obese people than in people with normal weight. Average CIT was almost one minute longer in men than women. Average CIT in obese men was slightly longer than in normal weight men. There was no difference in average CIT in obese and normal weight women. The differences were not statistically significant.Conclusions. This study demonstrates that the claim that endoscopic examination of the lower gastrointestinal tract is easier to perform in obese people cannot be objectively confirmed.
Can a healthcare worker be a source of an infection of a patient – a risk of transmitting the chickenpox and shingles virus VZV by the staff of hospital wards – preliminary research findings.
Authors: Stryczyńska-Kazubska Joanna , Małecka Ilona , Biskupska Maria , Bilski Bartosz , Pietrzycka Dorota , Wysocki Jacek
Published: April 2017

Introduction. Chickenpox is a highly infectious disease, caused by the Varicella-zoster virus. An infection during pregnancy poses particular risk, as it may have serious consequences for both the pregnant woman and the fetus. The only effective and safe method of preventing chickenpox is protective vaccination.Aim. This study aims to assess the risk of contracting the Varicella-zoster infection in a selected population of hospital workers, as well as the further transmission of the virus to newborns, mothers and older children.Materials and Methods. A survey was conducted in September 2014 in three public hospitals in Poznań, among nurses and midwives working in paediatric, neonatal and maternity wards. 136 nurses and midwives participated in the survey.Results. The analysis of the findings reveals that 114 staff members of the hospital wards, i.e. 83.82%, have had chickenpox in the past, 14 respondents (10.29%) have never had this illness, and 8 (5.88%) do not know if they have been ill, which means that 16% of the respondents could potentially contract chickenpox. For the majority of nurses and midwives (103) the infection had taken place before they started work. However, 11 respondents (8,08) were infected during employment.Conclusions. 1) Nearly one out of 4 hospital staff members had no history of chickenpox contraction at the beginning of their employment. 2) Nearly 15% of the workers confirm that at the beginning of employment their immunity status was established on the basis of an interview. 3) The majority of employees negatively interviewed for chickenpox history have not been recommended to be vaccinated against this disease.
Assessment of women’s awareness about reproductive and breast cancers
Authors: Kosińska Karina Weronika , Lubawa Weronika Maria , Szczęśniak Magdalena , Plagens-Rotman Katarzyna , Miechowicz Izabella , Bączyk Grażyna , Ulatowska Agnieszka , Umbreit Michał
Published: April 2017

Introduction. The aspect of prevention and treatment of malignant tumours is a key problem of public health in Poland, posing a great challenge for the health care system. A perfect method of fighting against neoplasms is prevention. Its widespread use may allow reduction in the risk of developing cervical and breast cancer. Aim. The aim of the paper was to assess women’s awareness about prophylaxis and risk factors related to the development of reproductive and breast cancers among women subject to the survey. Materials and Methods. The analysis comprised a group of 154 women at the age from 17 to 70. The study was conducted between 17 March and 30 July 2015. The research tool used in the study was an independently prepared survey questionnaire. Results. The biggest group of respondents (48.70%) was made up of women at the age from 20 to 30. 68.83% of the women had a secondary level education, 42.20% were women from cities of between 51.000 to 100.000 inhabitants and only 1.94% represented large cities of over 500.000 inhabitants. A change in the size or shape of the breast (88.96%) and changes in the look of the nipple (86.36%) were quoted as the most frequent symptom of breast cancer.Conclusions. The knowledge about reproductive organs and breast cancer prevention among women is not fully satisfactory and needs to be broadened. Media (internet, television) were the most popular source of information on cancer prevention among the respondents. It is necessary for family doctors and midwives to intensify health-care activities aimed especially at women who are the age associated with an increased risk for cancer.
Products of plant origin – benefits and the potential risk for the consumer
Authors: Karasiewicz Monika , Bogacz Anna , Krzysztoszek Jana , Pędziwiatr Daniel , Czerny Bogusław
Published: April 2017

Phytochemical compounds are widely used in traditional medicine in the treatment of many ailments. In recent years, an increasing interest is observed in the use of new natural bioactive substances and whole standardized extracts in the prevention and therapy of diseases. Some of these are the components of the diet, diet supplements or at higher doses are used as herbal medicines. Many phytochemicals have documented a beneficial effect on health, but they must be used properly. Therefore, it is important to inform about differentiating between herbal medicine and dietary supplement. Further, the possibility of interactions with synthetic drugs and the mechanisms of these effects is necessary to describe for the safety of phytotherapy. The goal of our paper is to show high prophylactic and medicinal potential of natural active compounds of plant origin. We also want to draw attention to the safety of their use by the consumer. Therefore, we present some studies on the benefical properties of natural active compounds, mainly in the prevention and treatment of cancers and neurodegenerative diseases. The results of the described studies are extensively discussed and their suitability for further testing in vivo and in clinical trials is examined. At the same time we show selected interaction of common medicinal plants or their raw materials with synthetic drugs.
Endoleaks after endovascular abdominal aortic aneurysm repair
Authors: Kramek Jakub Tomasz , Stępak Hubert , Oszkinis Grzegorz
Published: April 2017

Traditional surgical repair and endovascular repair (EVAR) are the treatment options for abdominal aortic aneurysm repair. EVAR as less invasive becomes a significant and widely accepted way of treatment aortic aneurysms with expanding number of procedures. This technique has a lover short-term mortality and a shorter hospital stay but is not free from complications. The most common complication after EVAR are endoleaks. For the first time summarised and assessed in 1997. Although it is often asymptomatic but may cause aneurysm expanding and rupture. Endoleak is defined as persistent blood flow into the aneurysm sac. It can be revealed intra-operatively or during the follow up – CT; arteriography, angio-MRI enables endoleak diagnosis. Usage of duplex sonography is questionable. In this mini-review we summarise endolek diagnostic, classification and treatment options.
Major adverse cardiovascular events in patients after acute myocardial infarction treated invasively and different patterns of glucometabolic disturbances evaluated at mid-term follow-up
Authors: Francuz Paweł , Podolecki Tomasz , Kozieł Monika , Kalarus Zbigniew , Kowalczyk Jacek
Published: April 2017

Objective:  To assess the impact of glucometabolic status (GS) evaluated at hospital discharge and at mid-term follow-up visit (FU-visit) on major adverse cardiovascular events (MACE) in patients (pts) with acute myocardial infarction (AMI) treated invasively.Material and Methods: Study encompassed 368 AMI-pts treated invasively, in whom GS was assessed by 2-hour post load glycemia at hospital discharge and at FU-visit after 6 months. Patients were divided into two groups with respect to GS at hospital discharge: abnormal glucose tolerance (AGT, n=149), normal glucose tolerance (NGT, n=219). Each of those groups was divided into two subgroups with respect to GS at FU-visit: persistent AGT (pAGT, n=101), transient AGT (tAGT, n=48), newly detected AGT (newAGT, n=114), persistent NGT (pNGT, n=105). Median follow-up duration after FU-visit was 24.5 months.Results: There was a trend towards more subjects with MACE in AGT than NGT group (24.2% vs. 16%; p=0.051). More AGT-pts were hospitalized due to decompensated heart failure (6% vs. 0.5%; p=0.002). However, there were no significant differences in MACE between subjects with pAGT and tAGT, including heart failure hospitalizations. Among NGT-pts there were no significant differences in particular MACE between newAGT-pts and pNGT-pts.Conclusions: In AMI-pts treated invasively, who had abnormal glucose tolerance at hospital discharge, the improvement in glucometabolic status after 6 months was not related to lower risk of hospitalization due to decompensated heart failure.
Cognitive functioning of women in pregnancy and early postpartum
Authors: Płotek Włodzimierz , Czarnecka-Iwańczuk Marta , Grześkowiak Małgorzata
Published: April 2017

Pregnancy and early postpartum is an extremely stressful time in a woman’s life. Emotional and cognitive functioning are mutually interconnected. The psyche also influences the physical health on the functional and physical basis. The physiological hormonal changes adapt woman to the development and labour of a child and reflect in the central nervous system functioning. In the presented manuscript, the basic psychological problems accompanying women in this period, as well as mutual relationships between the hormonal and central nervous systems during pregnancy and early postpartum have been presented.
Factors associated with overhydration in peritoneal dialysis patients
Authors: Sikorska Dorota , Pawlaczyk Krzysztof , Olewicz-Gawlik Anna , Roszak Magdalena , Samborski Włodzimierz , Baum Ewa , Kałużna Małgorzata , Wanic-Kossowska Maria , Lindholm Bengt , Oko Andrzej
Published: April 2017

Aim. Overhydration is a prevalent problem in peritoneal dialysis (PD) patients. The aim of the study was to evaluate the effect of several factors on the development of overhydration in PD patients. Material and Methods. The study was performed on 74 PD patients, who were divided into two groups according to bioimpedance analysis hydration status (OHBIA): Group A OHBIA < 1.1 L (n = 40) and Group B OHBIA ? 1.1 L (n = 34). The assessments of the adequacy of the dialysis dosage were based on the Kt/V ratio as well as weekly creatinine clearance. To evaluate the permeability of the peritoneal membrane a standard peritoneal equilibration test was used.Results. A statistically significant difference between the groups was found in: the average age of patients (53 ± 18 vs. 62 ± 14 years; p < 0.03), the prevalence of diabetes (27.5% vs. 55.9%; p < 0.02) and residual diuresis (1.7 ± 0.8 vs 1.2 ± 0.9 L; p < 0.05). There was no statistically significant difference in gender distribution, although attention is paid to the greater participation of male in overhydrated group. The study found no statistically significant differences between PD vintage, type of PD, assessment of adequacy of PD and other parameters describing the PD method. Logistic regression model selected diabetes (p < 0.03) as a significant risk factor for the occurrence of hypervolemia.Conclusions. Diabetes and older age are potential predisposing factors for the development of overhydration in PD patients. Overhydrated PD patients may have relatively high parameters regarding adequacy of dialysis therapy. Probably the most important protective factor in PD patients is residual diuresis
Surgery of early stage breast cancer in older women – multicenter study and review of 143 cases
Authors: Saad Abdalla Abdalla , Adamczyk Beata
Published: April 2017

Most of breast cancers are diagnosed in females over 50 years of age, however it is found that about 30% of the disease diagnosed with women above 70 years. Generally speaking, those patients is treated with a smaller range of treatment which usually offered to the younger group of patients. Despite the presence of many comorbidities, however the patient may still have a good physiological reserve, which make offering a radical surgery of the cancer very possible. Age should not be a determinant for quality of care in breast cancer. In this paper, we looked to 143 breast cancer patients with age >70 years had been operated. The oldest was 86. ASA assessment tool used Pre-operatively. Mastectomy done in 70% where 30% underwent Breast Conservation Surgery. Axillary surgery done in 94% of cases (52% Sentinel lymph node biopsy and 42% axillary clearance). The histology of the removed cancers showed invasive ductal carcinoma in 76% of cases, invasive lobular carcinoma in 11%, with DCIS in 06%. After surgery, every patient has been offered the individual suitable adjuvant treatment as chemotherapy, radiotherapy, Herceptin or hormonal manipulation. As those patients can stand the radical surgery and live with a good life quality after treatment, we advise to extend the screening program beyond the current recommended age. Also we recommend further research to understand more about the biology of the breast cancer in the older age group and disseminate geriatric assessment tool as Adult Co-morbidity Evaluation (ACE-27) to provide a proper evaluation of the patient status prior to final management decision.
Quality of life of the elderly residents of nursing homes and patients of the Psychogeriatric Day Ward
Authors: Pawlaczyk Magdalena , Gąsior Teresa , Michalak Michał , Jóźwiak Andrzej , Zasadzka Ewa , Matecka Monika , Pawlaczyk Mariola
Published: April 2017

Introduction. Due to the prolonged average life span and constantly increasing number of the elderly, research of this population’s quality of life (QoL) is being conducted to assess the spheres requiring improvement. Aim. To assess and compare the life quality in different domains between residents of nursing homes (NH) and patients of the Psychogeriatric Day Ward (PDW).Material and Methods. The study encompassed 68 PDW patients and 62 NH residents. The WHOQOL-BREF questionnaire and a structured interview concerning diseases, different forms of support and activities preferred were used. Results. Women predominated among the subjects (83%). The elderly aged 75–90 constituted the majority (64.62%). The average assessment of QoL in the whole group amounted to 3.6 points. No significant differences in the assessment of QoL satisfaction and one’s own health satisfaction were observed between PDW patients and NH residents. The participants of both groups assessed the highest QoL in the environment domain and the lowest in the social relationships domain. A relationship between higher QoL in the physical health domain and participation in social forms of spending free time was observed. Relationships between QoL in particular domains and age, marital status and length of stay in NH were found.Conclusions. Elderly people’s QoL, similarly to their satisfaction with health, were on an average level regardless of the institutional care. The QoL remains in a significant relationship with health. The changing needs of the elderly should be the basis for creating an individual plan of professional support.
LA HISTORIA COMO "LUGAR TEOLÓGICO" EN LA TEOLOGÍA LATINOAMERICANA DE LA LIBERACIÓN
Authors: Costadoat Jorge
Published: April 2017

Gaudium et Spes tuvo un impacto enorme en el desarrollo de la autoconciencia de la Iglesia latinoamericana y de la Teología de liberación. GS ofreció un método para observar teológicamente los acontecimientos, en el entendido que Dios habla en ellos y que, en consecuencia, es necesario discernir su presencia y voluntad en el presente histórico. La Teología de la liberación utilizó el concepto de “lugar teológico” para denominar la presencia de Dios en el continente de la época, especialmente para afimar que el “lugar teológico” por excelencia son los pobres. Este artículo se concentra en el uso que los teólogos de la liberación hacen de esta categor ía, pues ella designa el supuesto fundamental del m étodo de la Teología de la liberación. Los resultados de la investigación arrojan un resultado inquietante. Los autores no entienden lo mismo por “lugar teológico”. El uso del término, por tanto, puede constituir una fuente de malentendidos.
Notes on a Family of Inhomogeneous Linear Ordinary Differential Equations
Authors: Qi Feng , Wang Jing-Lin , Guo Bai-Ni
Published: April 2017

In the note, the authors find several simple and explicit forms for a family of inhomogeneous linear ordinary differential equations studied in "D. Lim, Differential equations for Daehee polynomials and their applications, J. Nonlinear Sci. Appl. 10 (2017), no. 4, 1303-1315; Available online at http://dx.doi.org/10.22436/jnsa.010.04.02".
Penerapan E-Module Berbasis Problem Based Learning untuk Meningkatkan Literasi Sains dan Mengurangi Miskonsepsi pada Materi Ekologi Siswa Kelas X MIA 6 SMAN 1 Karanganom Tahun Pelajaran 2014/2015
Authors: IMANINGTYAS CITRA DEVI , KARYANTO PUGUH , NURMIYATI NURMIYATI , ASRIANI LILIK
Published: April 2017

This research aims to increase the scientific literacy and decrease the student’s misconception in class X MIA 6 of SMAN 1 Karanganom by applying e-module based on the concept of Problem Based Learning (PBL). The type of the research is a classroom action research which consist of two cycles. Each cycles applied: planning the learning activity, then implementing those plan, next was observing the students’ activity and finally complimenting the whole activities during a cycle. The research subject is the students of class X MIA 6 at SMAN 1 Karanganom. There are 11 boys and 23 girls. The data validation used triangulation method. The data of the research were obtained by formulating the test, the observation and the interview. The obtained data  were analyzed using the descriptive technique. The results of the research showed the implementation of e-module based on the concept of PBL decrease the students’ misconception on the ecology subject with the explanation: the population concept decreased 21%, the comunity concept run into reduction 22%, the ecosystem concept  went down 21% and the ecology concept in ‘Science, environment, technology, and society’ context reduced 26%. The analysed result also indicated that the scientific literacy has increased 20.6%. The result of the research evidenced that implementation of e-module based on the concept of PBL could increase the scientific literation and decrease the students’ misconception on the ecology subject.

 
Keywords:     E-module with based Problem Based Learning, misconception, scientific literacy
Factors Governing the Predicted Performance of Multilayered Metal-Mesh Screens
Authors: Wu Chu-Hsiang , Sharma Mukul M. , Chanpura Rajesh , Parlar Mehmet , Ayoub Joseph
Published: April 2017

Multilayered metal-mesh screens (MMSs) are widely used as standalone screens for sand control in unconsolidated formations. The nominal rating of such screens is usually determined on the basis of the specifications of the filter layer. It is often found that screens with the same filter-layer nominal rating perform differently. It is shown in this study that the primary reason for this is that the sand-retention performance of multilayered MMSs is a strong function of not only the filter layer but also the protection and the support layers.

This paper presents a systematic study that shows how the overlap between different mesh layers, the alignment of the protection and support layers, and the relative pore-size ratio, defined as the ratio of pore size of the protection/support layer to that of the filter layer, have a large impact on the sand-retention performance of an MMS. The pore-size distribution (PoSD) of multilayered plain-square-mesh (PSM) and plain-Dutch-weave (PDW) screens is calculated with a novel numerical technique. Influences of screen sintering, coupon sampling, and screen designs on the PoSD of a screen are modeled by varying the layer overlap, shifting the layer alignment, and modifying the design of the protection and support layers. The PoSD data are used as an input into an analytical model for evaluating sand production of PSM screens in slurry-type sand-retention tests (SRTs) for screen-design optimization.

For PSM screens, the results show that the PoSD of a multilayered screen can be very different from the PoSD of the filter layer. In general, a decrease in sand production with an increase in layer overlap is observed; the trend exists irrespective of how mesh layers are aligned. A change in mesh alignment is found to cause a variation in sand production even with the same filter-layer pore size and layer overlap. The nominal rating of the filter layer of a multilayered PSM screen should be used to estimate sand production only when the pore sizes of the protection and support layers are much larger than the pore size of the filter layer. For PDW screens, layer overlap is shown to dominate the screen performance by affecting the filter-layer pore size. The PoSD of a PDW screen is found to be less affected by variations in layer alignment and relative pore-size ratio.

This study clearly shows that the layer overlap, layer alignment, and relative pore-size ratio between mesh layers can have a significant impact on the sand-retention performance of a multilayered MMS. As such, widely different screen performances can be expected for screens with the same nominal screen rating. Our results have a direct bearing on how MMSs are manufactured, selected, and specified. Increasing the relative pore-size ratio appears to be a promising screen-design approach for obtaining consistent screen performance for multilayered MMSs.
Gelled Isolation Fluid Makes Refracturing Well Feasible
Authors: Wheeler Richard , Williams V. , Mayor J. , Khan S. , Everson N. , Steinhardt A.
Published: April 2017

Gelled isolation fluids are used in various applications throughout the oilfield for creating access to a specific segment of the wellbore while leaving the remaining portion of the wellbore unaffected. In single well applications, zones are isolated whereas laterals are isolated in multi-lateral completions. Gelled fluids are typically used in scenarios where isolation is not feasible or too costly to be obtained by use of a packer, plug or other downhole tool. A gelled fluid offers the benefits of being both temporary and easily cleaned up after the treatment. The objective in this application was to use a low cost gelled fluid to fully isolate existing perforations along a lateral to stimulate new zones.

The candidate well selected for re-fracturing was originally completed without being stimulated due to water zones nearby. The 4200 feet of semi-continuously perforated horizontal section did not produce as expected. In order to fracture the targeted zones, a gelled fluid was used to seal off the existing perforations and maintain zonal isolation between fracturing stages. The gelled fluid was designed and optimized in the lab for the well and treatment conditions. An inner string with sliding sleeves was placed in the horizontal section of the well. The gelled fluid was then pumped into the annular space between the original casing and an inner tubing string and allowed to setup before fracturing began.

Before the job was pumped, laboratory testing and simulation concluded that the gelled fluid would be placed within the pump time of the job and hold for the expected time frame of the fracturing operations. Due to the constraints of the wellbore tooling, completion system, and well conditions, this testing provided detailed operational guidelines on placement time, pump rate, fluid shear rate and temperature constraints before committing to pump the job. The fluid was successfully placed and maintained isolation for the duration of the 36 hours of a 9 stage stimulation treatment. Pressure on the backside of the tubing string was monitored throughout all 9 stages and remained fairly constant throughout the stimulation process indicating that zonal isolation was achieved and maintained.

The novelty of this work included the application of using a gelled fluid in conjunction with a sliding sleeve system to optimize the zones for stimulation and address a specific need of limiting flush volumes and pump downs. This unique application provides knowledge on additional options for using this type of isolation gel for these types of applications in the re-stimulation market as a cost effective option.
Selective Adsorption and Transport Diffusion of CO2-CH4 Binary Mixture in Carbon-Based Organic Nanopores
Authors: Kazemi Mohammad , Takbiri-Borujeni Ali
Published: April 2017

Production from shale gas reservoirs provided a unique opportunity for underground storage of the CO2. Because of the higher affinity of CO2 to the organic matter of shale compared to CH4, injecting CO2 into these resources can cause the adsorbed CH4 molecules to be desorbed and then replaced by the CO2 molecules. In this work, we perform molecular dynamics simulations to calculate the Onsager and Fickian diffusion coefficients of CH4 and CO2. Onsager coefficients of the pure species increase as its partial pressure increases and then level off at higher pressures. The off-diagonal Onsager coefficients increase as CH4 pressure increases up to a CO2 pressure of approximately 100 atm and followed by a reduction in the coefficients. The Onsager diffusion coefficients of CO2-CO2 are the highest compared to CH4-CH4 and CO2-CH4 diffusion coefficients. The Onsager diffusion coefficients for both species are a function of their occupancies. As concentration of a species increases, its Onsager diffusion coefficient increases as well. The results also demonstrated that the off-diagonal terms in the Onsager and Fickian diffusion coefficients matrix have the same order of magnitude as the diagonal terms and therefore cannot be ignored in modeling of CO2 sequestration in shale.