bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis and Antioxidant Activity (4-(Benzo[d][1,3]-dioxol-6-yl)-tetrahydro-2H-pyran-4-yl)methylsubstituted Aryloxypropanolamines, Aminoamides and Sulfanilamides
Authors: Arustamyan Zh. S. , Margaryan R. E. , Mkryan G. G. , Aghekyan A. A. , Panosyan G. A. , Buniatyan Zh. M. , Muradyan R. E.
Published: December 2024

Alkylation of 3,4-methylenedioxyphenylacetоnitrile with 2,2-dichlorodiethyl ether gave the corresponding nitrile the reduction of which with lithium aluminum hydride isolated (4-(benzo[d][1,3]dioxol-6-yl)-tetrahydro-2H-pyran-4-yl)methylamine. The interaction of the latter with aryloxymethyloxiranes gave the corresponding 1-((4-(benzo[d][1,3]dioxol-6-yl)-tetrahydro-2H-pyran-4-yl)methylamino)-3-aryloxypropan-2-ols. By the reaction of the same amine with chloroacetyl chloride isolated chloroacetamide, the interaction of which with a variety of secondary amines and heterylthiols synthesized the corresponding substituted amino- and sulfanylacetamides - derivatives of (4-(benzo[d][1,3]dioxol-6-yl)-tetrahydro-2H-pyran-4-yl)methylamine. The antioxidant activity of the obtained compounds was studied.
Structure and Conformational Analysis of 5,5-Bis(bromomethyl)-2-methyl-2-(4-chlorophenyl)-1,3-dioxane
Authors: Khazhiev Sh. Yu. , Khusainov M. A. , Khalikov R. A. , Kataev V. A. , Tyumkina T. V. , Mesheryakova E. S. , Khalilov L. M. , Kuznetsov V. V.
Published: December 2024

The structure of 5,5-bis(bromomethyl)-2-methyl-2-(4-chlorophenyl)-1,3-dioxane was investigated using NMR 1Н, 13С and X-ray data. Molecules of this compound in crystalline phase and in solutions have a chair form with axial orientation of aromatic substituent. The rout of conformational transformations and the potential barriers of internal rotation of aromatic group for isolated molecule and solutions in chloroform and benzene (explicit model) were established by the computer simulation using DFT approach PBE (basis sets 3ζ and def2-SVP).
Synthesis of 3-Alkyl-5-(diethylaminomethyl)-1-(1,3-thiazole)pyrazoles
Authors: Karayeva A. R. , Shatirova M. I. , Mamedov B. A. , Nagieva Sh. F. , Gadzhiyeva L. I.
Published: December 2024

By the reaction of 3-alkyl-5-(diethylaminomethyl) pyrazoles with chloroanhydride of monochloroacetic acid, the pyrazoles with chloromethyl carbonyl substituent have been synthesized. Due to presence of reactive COCH2Cl groups in a molecule, the pyrazoles have been subjected to heterocyclization with thicarbamides (thiobenzamide, thicarbamide and phenylthiocarbamide) in the presence of triethyleamine in a medium of ethanol, as a result of which the previously unknown 3-alkyl-5-diethylaminomethyl-1-(1,3-thiazol)substituted pyrazole derivatives have been obtained.
Thiophenols Addition Reactions to Siliconcontaining Enynes and Enynones
Authors: Sokov S. A. , Gordon K. V. , Zlotskii S. S. , Golovanov A. A.
Published: December 2024

As well as the cross-conjugated enynones, propynylidene derivatives of malonic ester and Meldrum’s acid that contain Me3Si, Et3Si and t-BuMe2Si groups, attach stereoselectively 4-methyl-, 4-methoxy- and 4-chlorothiophenol under conditions of base catalysis. In the process, there are sulfanilic compounds containing buta-1,3-diene and penta-1,4-dien-3-one fragments formed in high yields. In the thiylation products of the enyne derivatives of malonic ester and Meldrum’s acid, Me3Si, Et3Si and t-BuMe2Si groups are retained; desilylation occurs during the thiylation of 5-trialkylsilyl-1-phenylpent-1-en-4-yn-3-ones. There are some certain regularities determined for observed reactions. We also developed stereoselective methods for the S-containing polyunsaturated compounds obtaining.
Multicomponent Cyclizations of Ethyl Trifluoroacetoacetate with Acetaldehyde and 1,3-Diamines to Heteroannulated Pyridines
Authors: Kushch S. O. , Goryaeva M. V. , Surnina E. A. , Burgart Ya. V. , Saloutin V. I.
Published: December 2024

A four-component approach was developed for the synthesis of cis- and trans-diastereomeric partially hydrogenated pyrido[1,2-a]pyrimidines and pyrido[2,1-b]quinazolines based on the cyclization of ethyl trifluoroacetoacetate with two acetaldehyde molecules and 1,3-diaminopropane or 2-aminomethylaniline. The zwitterionic salt of tetrahydropyrimidine was isolated as a by-product from the reaction with 1,3-diaminopropane. And from the reaction with 2-aminomethylaniline 7-hydroxy-7-(trifluoromethyl)-5,5a,6,7,8,11-hexahydro-9H-pyrido[2,1-b]quinazolin-9-one was obtained as a result of the participation of one aldehyde molecule. The diastereomeric structure of the synthesized heterocycles was established on the basis of 1Н, 19F, 13С NMR spectroscopy and XRD. A mechanism for the formation of new heteroannulated pyridines was proposed.
Fire performance and characterization of geopolymer foams using fly ash and coal gangue
Authors: Mróz Katarzyna , Figiela Beata , Korniejenko Kinga
Published: December 2024

The paper introduces foamed geopolymers as effective thermal insulation materials for buildings, with the ability to withstand high temperatures. The production methods for achieving a porous microstructure in geopolymers are discussed, emphasizing the use of foaming agents like aluminium powder. The presented research focuses on developing geopolymer foams from industrial waste materials [fly ash and coal gangue] with enhanced thermal and fire resistance while maintaining robust mechanical properties. The novelty lies in evaluating these foams at a medium-sized panel scale [750 mm x 750 mm x thickness] and assessing their fire resistance through comprehensive tests, differentiating it from existing literature that primarily explores smaller-scale materials. Class F fly ash from Skawina power plant, Poland and waste rock from coal mining KWK Wieczorek, Katowice, Poland were used for preparation of geopolymer foam. The research aims to contribute insights into the fire performance of geopolymer foams under ISO 834-1 fire scenario, paving the way for potential applications as thermal insulation panels in building facilities. Results from fire exposure tests, post-fire mechanical property assessments, SEM observations, EDS analyses, XRD analyses, as well as ageing effects are presented and discussed. While foamed geopolymers demonstrate resilience and fire resistance, variations in their mechanical properties and microstructure due to fire exposure are highlighted. The research underlines the potential of employing geopolymer foams as a sustainable solution for thermal insulation in construction, opening up further exploration and application in the construction industry.
Transcranial Direct Current Stimulation and Executive Function in Athletes: A Comprehensive Review
Authors: Ghayebzadeh Shahrouz
Published: December 2024

Transcranial direct current stimulation (tDCS) has gained attention as a non-invasive brain stimulation technique with potential to enhance cognitive and executive functions in various populations, including athletes. In this review, we examined the effects of tDCS on cognitive and executive functions in athletes. Risky decision-making is a critical aspect of athletic performance, influencing choices related to strategy, tactics, and responses during gameplay. tDCS can improve decision-making abilities in athletes, particularly when targeting the dorsolateral prefrontal cortex (DLPFC). Enhanced DLPFC activity improves accuracy, speeds decision-making, and reduces impulsive choices. However, the effects of tDCS are also influenced by other factors such as electrode placement, stimulation parameters, and individual differences. Optimal protocol standardization and individualized approaches can maximize the benefits of tDCS in athletes. We also discussed the potential implications of tDCS for cognitive functions in sports and identified areas for future research.
Arabic-Nougat: Fine-Tuning Vision Transformers for Arabic OCR and Markdown Extraction
Authors: Rashad Mohamed A.
Published: December 2024

We introduce _Arabic-Nougat_, a suite of OCR models designed to convert Arabic book pages into structured Markdown text. Building on Meta’s _Nougat_ architecture, _Arabic-Nouga_t includes three specialized models: _arabic-small-nougat, arabic-base-nougat, and arabic-large-nougat_. These models are fine-tuned using a synthetic dataset, _arabic-img2md_, consisting of 13.7k paired samples of Arabic book pages and their Markdown representations. Key innovations include the _Aranizer-PBE-86k_ tokenizer, which optimizes tokenization efficiency, and the use of torch.bfloat16 precision and Flash Attention 2 for efficient training and inference. Our models significantly outperform existing methods, with _arabic-large-nougat_ achieving the highest Markdown Structure Accuracy and the lowest Character Error Rate. We also release a large-scale dataset of 1.1 billion Arabic tokens extracted from over 8,500 books using our SOTA model, providing a valuable resource for further Arabic OCR research. All models and datasets are open-sourced, and our implementation is available at https://github.com/MohamedAliRashad/arabic-nougat.
Climate and Environmental Changes: Reflections and Prospects for the Future of the Mediterranean Area — Food Security and Climate Change: Agricultural Considerations
Authors: Borsetta Germana
Published: December 2024

The Mediterranean region, renowned for its rich biodiversity and complex interplay of cultures, faces significant challenges due to climate change, population growth, and socio-economic shifts. The region's agricultural system, integral to its economy and food security, must adapt to meet the demands of a growing population while preserving environmental sustainability. This paper explores the main threats to Mediterranean agri-food systems, such as unsustainable practices, water scarcity, and soil degradation, and emphasizes the need for collective strategies to build resilience. The analysis includes three case studies from the Mediterranean area, that illustrate diverse approaches to sustainable agricultural development and adaptation, highlighting both shared challenges and innovative solutions.
CityWalker: Learning Embodied Urban Navigation from Web-Scale Videos
Authors: Liu Xinhao , Feng Chen
Published: December 2024

Navigating dynamic urban environments presents significant challenges for embodied agents, requiring advanced spatial reasoning and adherence to common-sense norms. Despite progress, existing visual navigation methods struggle in map-free or off-street settings, limiting the deployment of autonomous agents like last-mile delivery robots. To overcome these obstacles, we propose a scalable, data-driven approach for human-like urban navigation by training agents on thousands of hours of in-the-wild city walking and driving videos sourced from the web. We introduce a simple and scalable data processing pipeline that extracts action supervision from these videos, enabling large-scale imitation learning without costly annotations. Our model learns sophisticated navigation policies to handle diverse challenges and critical scenarios. Experimental results show that training on large-scale, diverse datasets significantly enhances navigation performance, surpassing current methods. This work shows the potential of using abundant online video data to develop robust navigation policies for embodied agents in dynamic urban settings.
Tatalaksana terkini krisis tiroid: case report
Authors: Irawan Budi , Mulyono Eddy , Suprabowo Salomo Hizkia , Mulyadi Ezra Michael , Ghufira Nanda
Published: December 2024

Krisis tiroid merupakan kegawatdaruratan dalam bidang endokrin yang paling sering dijumpai dengan angka morbiditas dan mortalitas yang sangat tinggi. Tercatat kurang dari 10% insiden krisis tiroid dari total pasien tirotoksitosis yang dirawat di rumah sakit, namun krisis tiroid ini angka mortalitasnya sebesar 20-30%. Penanganan pada kasus ini dengan tujuan membatasi produksi hormon tiroid yang berlebihan dengan cara menekan produksi atau merusak jaringan tiroid. Jenis penelitian ini adalah laporan kasus yang cenderung memperhatikan permasalahan dan gambaran penatalaksanaanya terutama di RSUD R.A.A Soewondo Pati terhadap kasus yang ingin ditemukan. Subjek dalam laporan kasus ini yaitu seorang perempuan berusia 53 tahun datang ke IGD RSUD RAA Soewondo Pati dengan keluhan demam. Alat pemeriksaan berupa pemeriksaan fisik dan alat pemeriksaan laboratorium. Teknik analisis data menggunakan analisis deskriptif dengan menggunakan kriteria Burch dan Wartofsky. Hasil analisis diperoleh skor kriteria Burch dan Wartofsky thermoregulatory dysfunction 37,9C skor +10, cardivascular HR 112x/mnt skor +10, atrial fibrilation skor +10, congestive heart failure Absent skor 0, gastrointestinal-hepatic dysfunction moderate skor +10, central nervous system disturbance skor +10, precipitating event skor 0, didapatkan total skor >45. Pada pemeriksaan EKG didapatkan gambaran atrial fibrilasi. Pada pemeriksaan penunjang darah lengkap didapatkan trombositopenia, leukositosis, hiponatremi, hipokloremia, CKMB 45 (<25), TSH <0,10 (0,25-0,50), total T3 3,51 (0,9-2.33), total T4 195,9 (57,9-150,6), eosinofil 0,10 (2-4%), neutrofil 74,90 (50-70%), limfosit 14,2 (25-40%), monosit 10,70 (2-8%). Pengelolaan secara agresif dilakukan secara intensif dengan pemantauan ketat di intensive care unit (ICU).
Determining the frequency of cardiovascular abnormalities in infants born to mothers with diabetes referring to Hazrat Masoumeh Hospital between the years 2021 and 2022
Authors:   Department of Obstetrics and Gynecology, School of Medicine, Qom University of Medical Sciences, Qom, Iran, Yousef Maryam , Arjmandnia Mohammad Hosein ,   Department of Pediatrics, School of Medicine, Hazrat-e Fateme Masoume Hospital, Qom University of Medical Sciences, Qom, Iran, Miraj Sepideh ,   Department of Obstetrics and Gynecology, School of Medicine, Nekouei-Hedayati-Forghani Hospital, Qom University of Medical Science, Qom, Iran, Mohammadbeigi Abolfazl ,   Department of Biostatistics and Epidemiology, School of Health, Research Center for Environmental Pollutants, Qom University of Medical Sciences, Qom, Iran, Hosseini Reihanehsadat ,   Department of Nurse, Faculty of Medicine, University of Virginia. Charlottesville, United States., Takmil Mahla ,   Department of Cardiology, Faculty of Medicine, Yazd University of Medical Sciences, Yazd, Iran., Rahimi Shima ,   Department of Obstetrics and Gynecology, School of Medicine, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Published: December 2024

ntroduction and aim: Research has shown that maternal diabetes is an important factor that increases the risk of various congenital heart defects. The purpose of this research was to investigate the presence of cardiovascular abnormalities in fetuses born from diabetic mothers.
Methods: This study was conducted as a Cross Sectional. The study population was all pregnant women who were referred to Hazrat Masoumeh (PBUH) Hospital for echocardiography during the years 1400 to 1401. Sampling was done among diabetic and healthy pregnant women by simple random method. Information First, the required information was collected through echocardiography findings in the patient's file and the data was analyzed using SPSS software and related tests.
Results: In this study, 13 infants (14.4%) had a cardiac abnormality, of which 6 infants (6.7%) were born to mothers with type 1 diabetes and 7 infants (7.8%) were born to mothers with type 2 diabetes. There were no significant differences found between the average age of the mothers (P=648), the gender of the infants (P=0.733), the weight of the infants (P=0.143), gestational status (P=0.229), maternal occupation (P=0.077), type of delivery (P=0.675), Apgar score at one minute (P=0.709), and at five minutes (P=0.736) between the two groups of type 1 and type 2 diabetes.
Conclusion: Our results show that babies born to mothers with diabetes are more likely to have congenital heart diseases. It is recommended to use transthoracic echocardiography as a screening tool to diagnose congenital heart diseases in babies born to diabetic mothers
Comparison of the efficacy and complication of Romiplostim and Rituximab in children with Chorionic Immune Thrombocytopenic Purpura
Authors:   Department of Pediatrics, School of Medicine, Amirkabir Hospital, Arak University of Medical Sciences, Arak, Iran, Felahati Vahid , Noori Simin ,   Department of Pediatrics, School of Medicine, Amirkabir Hospital, Arak University of Medical Sciences, Arak, Iran, Dorreh Fatemeh ,   Department of Pediatrics, School of Medicine, Amirkabir Hospital, Arak University of Medical Sciences, Arak, Iran., Noori Azadeh ,   Department of Pediatrics, School of Medicine, Hazrat-e Fateme Masoume Hospital, Qom University of Medical Sciences, Qom, Iran., Atarod Mohammad Hossein ,   Student Research Committee, School of Medicine, Qom University of Medical Sciences, Qom, Iran.
Published: December 2024

Introduction: Idiopathic thrombocytopenic purpura (ITP) is a chronic autoimmune disease that manifests as persistent thrombocytopenia and mucocutaneous bleeding. The aim of this study was to evaluate the effects and side effects of two drugs, Rituximab and Romiplostim, in children with ITP.
Materials and methods: This prospective cohort study included children with ITP who were prescribed Romiplostim and Rituximab. The study followed the children for six months to monitor the medication's effectiveness and side effects, with the treatment response defined as an increase in platelet count to over 30,000 per cubic millimeter of blood. The patients were evaluated monthly for possible side effects such as fever, rash, respiratory infections, and peripheral edema. The data obtained from the patients were then analyzed using SPSS version 26 software.
Results: In the current study, 140 children were included, with 70 children in each of the Rituximab and Romiplostim groups. The average age of the children participating in the study was between 8-9 years. There was no significant difference between the two study groups in terms of age. Changes in the average platelet count during 9 measurements were significantly higher in the Romiplostim group compared to Rituximab (P<0.001). Additionally, the treatment response rate was significantly higher in the Romiplostim group than in the Rituximab group (71.4% vs. 48.6% and P=0.006). In the present study, none of the children taking either drug experienced peripheral edema. When examining other side effects related to the use of these two drugs, it should be mentioned that the rates of fever, skin rashes, and respiratory infections, although not significantly different between the two study groups during the nine repeated measurements (P>0.05), were generally lower in the Romiplostim group than in the Rituximab group during the second to fourth weeks of the study.
Conclusions: Romiplostim demonstrates superior efficacy compared to rituximab in raising peripheral blood platelet counts in pediatric patients with immune thrombocytopenia purpura. Furthermore, the treatment response rate is higher with Romiplostim and it is also associated with fewer complications when compared to rituximab.
2-AFC for Detectability of Low Contrast Object of CT Images Scanned with Two Doses and Recontructed with Various Iterative Recontruction (IR) Levels
Authors: Revita Dewantari  , Choirul Anam  , Heri Sutanto  , Ariij Naufal  , Riska Amilia  , Sarah I. Izmi  , Hilda S. Putri  , Pingky S. Dewi  , Indah R. Ilham  , Freddy Haryanto  , Adiwasono M. B. Setiawan
Published: December 2024

This study aims to evaluate images of the low contrast and small objects of the American Association of Physicists in Medicine (APPM) computed tomography (CT) phantom scanned with two doses and reconstructed with various iterative reconstruction (IR) using the 2-alternative forced choice (2-AFC) method. A module 610-06 of the APPM CT phantom had been scanned with a GE Revolution Apex CT scanner. The module was scanned with two difference radiation doses of 40.8 mGy and 57 mGy. The images were reconstructed with various IR levels of 0, 20, 40, 60, 80, and 100%. Detection of the low contrast object (i..e. 10 HU difference) with size of 3 mm was performed using the 2-AFC. The question bank has a total of 120 questions, with each type of data has 10 questions. This study involved 6 medical personnel having experience periods of less than three years (3 people) and more than three years (3 people). It is found that percent correct increases with increasing IR level and radiation dose. 100% correct at a dose of 40.8 mGy occurs at an IR level of 100%. Meanwhile, 100% correct at a dose of 57 mGy occurs at an IR level of 40%. Expert medical personnel who have worked for more than three years have a greater percent correct than medical personnel who have worked for less than three years. A study using 2-AFC on low contrast detectability for various IR level and two different doses has been performed. It was found that IR level and radiation dose increase detectability of the low contrast object.
EMPLOYMENT AS AN INTEGRATIVE ASPECT OF UKRAINIAN ECONOMIC MIGRATION: LIMITS, BARRIERS AND CHALLENGES IN CZECH CONTEXT
Authors:   Donetsk State University of Internal Affairs, Kopotun Igor , Strnad Štěpán ,   University of South Bohemia in České Budějovice
Published: December 2024

The article is devoted to one of the main aspects of integration of foreign migrants, namely employment. The target segment is the Ukrainian community. The contribution is based on the theory of market segmentation, which is used to assess the structure of the Czech labor market. The analysis is carried out on three interrelated levels. The growth of the Ukrainian population in the Czech Republic, irregular practices in the field of residence and employment regimes, and the experience of Ukrainians with settling in the Czech Republic. The most common phenomena include the so-called client system, employment under a trade license within the so-called black market system, and illegal labor activities, as well as related synergistic effects (labor exploitation, human trafficking and illegal employment, abuse of office, asylum procedure) blocks adequate economic, social and community integration and increases the risk of segregation at the place of residence. It has been established that the full integration of foreigners is mainly hindered by their employment in the labor market, due to a number of persistent negative trends. One of them is illegal employment, as well as the abuse of the institution of secondment of workers in the form of secondment of Ukrainians by foreign employers to companies that send these workers to work for other business entities. This leads to a chain bailout aimed at concealing the performance of dependent work by foreigners for employers in the Czech Republic. Equally important is the way of concealing employment agency in the form of misuse of an employment agency, when instead of proper employment of individuals, a business relationship is established with the purpose of temporarily entrusting them to the user.

Key words: foreign workers; Ukrainians; integration; labor market; migration; Czech Republic.
Análise Epidemiológica da Mortalidade Ocasionada pela Leptospirose na Região Sul do Brasil no Período 2017-2022
Authors: Frederico Gustavo Moreno , Barros Emillie Pinheiro , Guedes Amanda Roberta de Oliveira , Oliveira Juliano Karvat de
Published: December 2024

O trabalho investiga a prevalência e os fatores de risco da mortalidade por leptospirose na região sul do Brasil. Trata-se de um estudo retrospectivo observacional que utiliza dados do DataSUS para analisar padrões de mortalidade e fatores associados entre 2017 e 2022. A leptospirose, uma doença bacteriana transmitida de animais para humanos, é prevalente em áreas tropicais e subtropicais e representa um sério desafio de saúde pública no Brasil, com uma estimativa de 60 mil mortes anuais. Observou-se que alguns fatores de risco podem justificar o aumento do número de casos. O estudo visou conscientizar sobre a importância da prevenção e orientar políticas públicas para reduzir a mortalidade causada pela leptospirose.
Strategies for Diversifying Tourism Services in the Context of Digital Society and Global Markets
Authors:   Dnipro State Agrarian and Economic University, Khalatur Svetlana M. , Zhylenko Kateryna М. ,   Oles Honchar Dnipro National University
Published: December 2024

The aim of the article is to study the strategy of diversification of tourism services in the context of digital society and global markets, which is associated with new challenges and opportunities that require adaptation of the services offered. Diversification allows tour operators to reduce risks and increase profitability, focusing on different categories of customers and expanding the range of services offered. The article analyzes the current state of tourism services in the world and in Ukraine. The relevance of strategies for diversification of tourism services in the context of digital society and global markets is substantiated. The main strategies for diversification of tourism services in the digital environment are proposed, among which are: geographical diversification; product diversification; diversification of the client base; diversification through partnerships; innovations in the field of sustainable tourism. It is also determined that in the context of globalization, external and internal factors have a significant impact on the development of the tourism market. Diversification strategies involve expanding businesses by entering new markets, creating new products, or changing existing business models in order to reduce risk and increase profitability, allowing companies to respond more effectively to changing market conditions, avoid dependence on a single product or market, and ensure sustainable development. Studying the diversity of tourism activities, some scientists consider the possibility of using the following types of diversification strategies: vertical (concentric); horizontal; conglomerate. The benefits of diversification include: 1) reduced risk: companies can avoid dependence on a single product or market, which helps minimize the risks associated with market changes or fluctuations in demand; 2) increasing the sales market: entering new markets or creating new products allows you to attract new customers and increase sales; 3) efficient use of resources: diversification allows you to use existing resources and competencies to create new products or enter new markets. The identified advantages and disadvantages of diversification strategies in tourism allowed to assess their impact on the development of digital society, which allows the development of a more efficient, competitive tourism sector of the global market.
Introduction of Value Chains as a Guarantee of Increasing the Investment Attractiveness of the Tourism Sector
Authors:   Vinnytsia Institute of Designing Clothes and Entrepreneurship Institute of Designing Clothes and Entrepreneurship, Biletska Natalia V.
Published: December 2024

The article is devoted to the study of the impact of value chains on the development of the tourism sector, increasing its investment attractiveness and competitiveness. The article is aimed at analyzing, systematizing and generalizing the theoretical and methodological foundations of the introduction of value chains to increase the investment attractiveness of the tourism sector. The article focuses on the transformation of the role of the consumer in the context of modern challenges of the tourism market, which forces travel companies to adapt their services to the individual needs of customers. The importance of using innovations and technologies to create complex tourist products that contribute to the differentiation of offers and improving their quality is highlighted. The study provides examples of successful integration of local enterprises, infrastructure development and attracting investments, which allows creating new competitive offers. The study revealed that the phenomena of the value chain and investments are closely related, since they play a key role in the economic development and competitiveness of enterprises and regions. The value chain as a sequence of stages through which a product or service passes from initial development to the final consumer, forms a certain value of the product or service, which is reflected in an increase in its value. The social, economic and ecological effects of the introduction of value chains are analyzed, which demonstrate the importance of integrating various aspects of tourism development to create a sustainable and effective tourist product that would meet both the needs of tourists and the socioeconomic and environmental goals of the relevant region. It is substantiated that the effects of value chains in tourism are inextricably linked to investments, since investments in various aspects of the tourism sector are the basis for creating and maintaining these effects. Thus, investments in tourism not only stimulate the economic development of regions, but also contribute to the preservation of cultural and natural resources, improvement of infrastructure and technologies, which, in turn, increases the competitiveness of the tourism sector and makes it possible to attract more tourists. It is further noted that the application of an integrated approach to the projecting and implementation of value chains has a positive effect on the creation of a high-quality tourism product that meets the modern needs of consumers and contributes to the development of regional economies.
Competitive Strategies for Innovation and Investment Development of Enterprises
Authors:   Livestock Farming Institute of National Academy of Agrarian Sciences of Ukraine, Romaniuk Oleksandr H. , Sierov Ivan V. ,   Livestock Farming Institute of National Academy of Agrarian Sciences of Ukraine
Published: December 2024

The article is devoted to the issues of competitive strategies of innovation and investment development of enterprises, because under the current conditions of globalization of the world economy and rapid technological and market changes, the competitiveness of enterprises is largely formed due to innovation and investment activity, which serves as a factor not only of effective development of enterprise, but also an important component of the development of national and global innovation systems. The article is aimed at studying the essence and assessing trends in the formation of enterprise competitiveness on the basis of the development of competitive strategies for innovation and investment development of agro-industrial production enterprises in modern realities. The article examines the issues of competitiveness of an enterprise on the basis of the development of competitive strategies for innovation and investment development of agro-industrial enterprises. It is revealed that the issues of innovation and investment development of enterprises in the agro-industrial complex are extremely relevant and require a radical solution, therefore, the effectiveness of economic, economic, and marketing activities depends on how correctly and economically justified agrarian enterprises develop and implement their own competitive strategies of innovation and investment development. The study defines the essence of the concepts of «strategy», «strategy of enterprise development», «competitive strategy of enterprise», «innovations», «investments», «competitiveness of enterprise». Competitive strategies of the enterprise are studied: strategies for the formation of competitive advantages; the strategy of ensuring the competitiveness of the enterprise and the strategy of its competitive behavior. It is substantiated that innovations are a key factor in the development and competitiveness of modern business. It is determined that the strategy of innovation and investment development is a system of long-term goals and objectives of the enterprise in the field of innovation and investment activities (as well as methods and tools for their achievement) and is aimed at renewing all aspects of business. The main components of the strategy of innovation and investment development are examined. It is substantiated that the competitive strategy of innovation and investment development allows enterprises of agro-industrial production to ensure sustainable competitive positions and long-term economic growth through constant technological renewal and increase in business efficiency.
The Conceptual Foundations of Formation of Innovation Potential of Enterprise
Authors:   Simon Kuznets Kharkiv National University of Economics, Kvashyna Yuliia A.
Published: December 2024

The Industry 4.0 conception, considered a phase of the Industrial Revolution, was proclaimed by President Klaus Schwab at the Davos World Economic Forum Annual Meeting 2011. Already in September 2015, at the UN summit in New York, the final document, titled «Transforming our world: the 2030 Agenda for Sustainable Development» was presented, where its global goals were defined. The developed countries of the world have passed five technological modes, and at present there are processes of transition to the sixth mode, in which the most important role is played by the processes of production of complex knowledge-intensive products. The economy of Ukraine remains in a state characterized as industrial, that is, it corresponds to the features of the fourth technological mode and does not provide opportunities for structural changes towards the development of high-tech industries. In addition, in the light of recent events related to russian military aggression, there is an urgent need to develop our own military-industrial complex, domestic high-tech enterprises that will be able to produce and supply high technological level weapons for the Armed Forces of Ukraine. From such positions, there is a need to analyze the best practices of world leading companies, their successful innovative practices for the development of their own strategic instruments and effective management tools for the development of domestic enterprises, the formation of their innovative potential. A certain range of problems of managing the innovation potential of domestic enterprises in extremely difficult conditions of martial law acquires a new meaning and requires the development and formation of modern approaches to their solution. The article analyzes the conceptual framework and summarizes the principles and approaches to the formation of the innovation potential of domestic enterprises.
Keywords and Semantic Domains in Annual Global Risks Reports through the Past Decade
Authors: Elzohiery Amira
Published: December 2024

Incorporating keyword analysis and semantic domain analysis, the present study linguistically investigated ten Global Risks Reports published by the World Economic Forum (WEF) from 2013 to 2024. The corpus comprised 174,800 word types and 405,366 word tokens. Using the features of Wmatrix and the concordance and collocation tools in Sketch Engine, the study identified the top themes, semantic domains, and patterns prevalent in the ten reports. The semantic domain analysis revealed deep insights into the details of these themes, patterns, and the types of language used compared to the keyword analysis. The results showed the obvious interplay between politics, the economy, technology, and the environment, with minimal attention given to humanitarian and social dynamics. Economic risks appear to be the most pressing risks according to these reports, with every theme ultimately boiling down to the economic situation. Additionally, the reports discussed governments’ economics without addressing their impact on citizens and their socioeconomic conditions. This study could be a valuable contribution to the literature that could aid in the tracking of long-term linguistic choices found in risk reports using corpus linguistics. It could also serve as a valuable reference for governments, institutions, or corporations that seek to interpret and analyze global risk reports.
Study of the dimensions of and countermeasures for improving the administrative efficiency of primary and secondary schools in western China: Taking MX Middle School as an example
Authors: Chang Junhong
Published: December 2024

With the deepening of education reform, improving the administrative efficiency of primary and secondary schools in Western China has become the key to promoting the balanced development of education. Taking MX Middle School as the research object, this paper analyzes the difficulties of administrative men in primary and secondary schools in western China in depth, including rigid management systems, uneven resource distributions, low information levels, insufficient incentive mechanisms and low participation of teachers and students. In view of these problems, this paper proposes a series of targeted counts and suggestions, such as optimizing the organizational structure, establishing a fair and transparent resource allocation mechanism, increasing the information input, improving the performance appraisal system and establishing a participation mechanism for teachers and students. th Improving the administrative efficiency of primary and secondary schools in Western China to promote educational equity, improve educational quality and promote the balanced development of regional education.
Obowiązek i ofiara
Authors: Zajączkowska-Łopatto Maria-Emilia
Published: December 2024

Epitafium dla tej wybitnej postaci okresu międzywojennego są słowa wiersza Kazimierza Wierzyńskiego: „Którzy wyzbyci wolności, Obezwładnieni przemocą Życia nie mają własnego I grobu dla własnych kości”.
Z Kijowa via Turcja do Brna
Authors: Kaleta Petr
Published: December 2024

Niełatwe losy karaimskich emigrantów w Czechosłowacji: o kijowskim Karaimie, żołnierzu Denikina, zootechniku Andreju Karakozie opowiada jego syn, Ivan.
Pitkäaikaistyöttömien digitaalinen minäpystyvyys arjessa
Authors: Mattila Liisa , Alaverdyan Aino , Pakkala Arja
Published: December 2024

Digitaaliset ja sosiaaliset eriarvoisuudet haastavat pitkäaikaistyöttömien digiosallisuutta. Kuntouttavan työtoiminnan kontekstissa tehdyssä haastattelututkimuksessa he kuvasivat kohtaamiaan saavutettavuuden, osaamisen ja hyötyjen digikuiluja. Kun omat taidot eivät riittäneet arjen digiongelmien ratkaisemiseen, korostui välillinen minäpystyvyys. Silloin pitkäaikaistyöttömät turvautuivat tai kohdistivat odotuksia digitukeen sekä laitteiden ja palveluiden käytettävyyteen. Omakohtaisella harjoittelulla ja tarvittavalla tuella pitkäaikaistyöttömien taidot ja digitaalinen minäpystyvyys vahvistuivat. Tämä auttoi heitä näkemään digitaalisuuden itsenäisyyttä lisäävänä ja myönteisenä resurssina arjessaan. Kollektiivinen minäpystyvyys ilmeni keskinäisen tuen ja tulevaisuuden uskon jakamisena, joka mahdollistui ryhmämuotoisessa digivalmennuksessa.
Kirjoita tutkimusta leikiten
Authors: Räikkönen Jenni
Published: December 2024

Luovaa kirjoittamista tutkijoille rohkaisee tutkijoita heittäytymään leikkiin, kun kirjoittaminen ei etene toivotulla tavalla. Kirja tarjoaa tutkijoille työkaluja, jotka auttavat avartamaan mieltä ja löytämään uusia näkökulmia ja oivalluksia suhteessa omaan tutkimusongelmaan ja aineistoon.
Luottamusta etsimässä
Authors: Hämäri Severi , Silvennoinen Piia
Published: December 2024

Aikuiskasvatuksen teemanumero pureutuu kriittiseen lukutaitoon eriarvoistuvassa digitaalisessa yhteiskunnassa. Sen punainen lanka on luottamus. Vääjäämätön digitalisoituminen, niin ylhäältä johdettuna kuin orgaanisesti kehkeytyvänä, synnyttää uudenlaisia yhteiskunnallisia jakolinjoja. Teemanumero vastaa aikuiskasvatuksen tehtävään digiosallisuuden lisäämisessä monitieteisellä otteella.
”Tutkimalla haluan olla mukana rakentamassa parempaa huomista”
Authors: Korhonen Mari
Published: December 2024

Johanna Kallio, 31, on Päivölän kansanopiston kasvatustieteen linjanjohtaja ja tuore tohtori, jonka työn ytimessä on ekologinen itsekasvatus. Aikuiskasvatustiedettä tarvitaan hänen mielestään yhteiskunnassa ratkomaan ekokriisien tuottamia laajoja yhteiskunnallisia haasteitaa. Tutkijana ja opettajana hän kokee vastuukseen edistää nykyistä kestävämpiä toimintaperiaatteita ja vaikuttaa siihen, että toimimme nyt emmekä vasta, kun on liian myöhäistä.
A construção de projetos político-pedagógicos crítico-emancipatórios: entre galhos e raízes das contradições sociais
Authors: Magalhães Lina Meireles , Milli Júlio César Lemos , Gehlen Simoni Tormohlen
Published: December 2024

Tendo em vista a nova Base Nacional Comum Curricular, que implica na reorientação dos Projetos Político-Pedagógicos das escolas de todo o país, buscou-se na pedagogia freireana um mecanismo de resistência e posicionamento crítico-emancipador - constituído na superação das contradições sociais. Assim, investiga-se o papel das contradições sociais no encaminhamento da construção de um Documento Orientador Municipal de Projetos Político-Pedagógicos. Para tal, pautou-se num estudo que articula as etapas da constituição de um PPP com elementos da pedagogia freireana, o qual auxiliou no desenvolvimento e na análise de um curso de formação de professores da rede municipal de ensino de Cairu/BA. No curso foram registradas informações por meio de videogravações, produções dos participantes e levantamentos acerca da comunidade, sendo analisadas conforme a Análise Textual Discursiva. Dos resultados, destaca-se que, na organização do documento que orienta a construção de outros Projetos Político-Pedagógicos, é necessário considerar a existência de diferentes realidades e por base das contradições num determinado contexto.
O papel do metatexto na análise textual discursiva: primeiras aprendizagens em curso de formação para professores
Authors: Silva Maria Juliana Farias , Corrêa de Paula Marlúbia
Published: December 2024

Este artigo objetiva apresentar uma atividade realizada, em sala de aula sobre o papel do metatexto na Análise Textual Discursiva, em um curso stricto sensu para formação de professores, no Programa de Pós-Graduação em Educação em Ciências e Matemática (PPGECM–BA). O corpus textual é composto por respostas obtidas de uma questão proposta a quatro mestrandos e três doutorandos do semestre 2023.1. Após submeter as contribuições e codificações aos processos de análise, foi possível identificar os diferentes sentidos presentes nas contribuições dos participantes na atividade proposta. Esse processo resultou em quatro categorias que diferenciam compreensões sobre o conceito de “pesquisa”: (i) caráter investigativo; (ii) caráter fenomenológico; (iii) caráter formativo e sistemático; e (iv) caráter criativo e inovador. Dessa forma, a atividade realizada para o exercício de análise textual qualitativa resultou numa prática oportuna para que, intencionalmente, cada pós-graduando construísse a estrutura necessária para registro no respectivo metatexto.
Taşınır Mallara İlişkin İyi Niyetle Kazanım Kuralının (TMK m. 988) Karşılıksız İşlemler Bakımından Uygulanabilirliği
Authors: Kurtulan Güner Gökçe
Published: December 2024

TMK m. 988 uyarınca, bir taşınırın emin sıfatıyla zilyedinden iyi niyetle yapılan kazanımlar, devreden kişinin tasarruf etkisinin eksikliği adeta onarılarak geçerli kabul edilir. Düzenlemede kazanımların ivazlı olup olmamasına göre bir ayrıma rastlanmamaktadır. Bu nedenle Türk hukuku öğretisindeki hâkim görüş, emin sıfatıyla zilyetten yapılan kazanımların ivazsız dahi olsalar korunması gerektiği yönündedir. İlgili düzenlemenin lafzi ve tarihsel yorumu bu görüşü destekler nitelikte olsa da hukukumuzda karşılıksız kazandırmalara ilişkin muhtelif hükümler, düzenlemenin amacı ve karşılaştırmalı hukuk verileri dikkate alındığında, hükmün teleolojik redüksiyona tâbi tutularak ivazlı kazanımlara hasredilmesi yerinde gözükmektedir.
Haksız Fiilde Hukuka Aykırılık Teorileri ve Bunların Sorumluluğa Etkisi
Authors: Korkmaz Fırat
Published: December 2024

Hukuka aykırılık haksız fiil sorumluluğunu derinden etkileyen, ona ismini veren teknik ve teorik yapıyı haiz bir unsurdur. Hukuka aykırılık kusur ve illiyet bağı unsurları birbirleri ile karışmaya müsait karakterdedirler. Hukuka aykırılıkla ilgili farklı teoriler bu unsurların birbirlerinden iyice ayrılmasına veya birbirlerine karışmasına alt yapı oluşturmaktadır. Yine hukuka aykırılıkla ilgili teoriler kusur ve sebebiyet sorumluluklarında farklı sonuçlar doğurmakta hatta sorumluluğu bu sorumluluk çeşitlerine doğru yaklaştırabilmektedir. Ayrıca mutlak hakların ve özellikle salt malvarlığı haklarının korunması ihtiyaçlarının giderilmesinde hukuka aykırılık kilit rol oynamaktadır. Makalede hukuka aykırılık unsuruyla ilgili teorilerin mahiyetleri, haksız fiilin unsurları ile ilişkileri ve sorumluluğa nasıl ve ne yönde etki ettikleri ortaya konulacaktır.
Caracterização da iatrogenia por polifarmácia em idosos como um problema de saúde pública: Uma revisão bibliográfica
Authors: Ponte Cyntya Halynne Ferreira da , Poleto André Luiz Oliveira , Branco Karina Meneses Fortes Castelo , Sousa Filho Emerson Alcantara de , Cunha Edmara Nayara Ferreira , Santana Nadia Prospero de , Pereira Junior José Lopes
Published: December 2024

Introdução: Iatrogenia é denominada como qualquer modificação patológica, efeito adverso ou complicação causada em pacientes por profissionais de saúde. Já o envelhecimento é um processo de modificação física, psicológica, social e/ou ambiental. O uso contínuo e simultâneo de cinco ou mais medicamentos por um único paciente (polifarmácia) idoso se configura um problema de saúde pública, devendo constantemente estudado nessa população. Objetivos: Relacionar a polifarmácia à iatrogenia em idosos no Brasil e caracterizá-la como um problema de saúde pública, conhecendo seu impacto na qualidade de vida; analisando a recorrência e os fatores de risco e predisponentes; e discutindo as principais complicações. Metodologia: Trata-se de uma revisão de literatura feita pelo levantamento bibliográfico nas plataformas PubMed, BVS (BVS Biblioteca Virtual em Saúde), SciELO (Scientific Electronic Library Online) e Lilacs (Literatura Latino-Americana e do Caribe em Ciências da Saúde). As publicações foram em língua portuguesa, inglesa ou espanhola, entre 2019 a 2023, usando os descritores "Aged", "iatrogenic disease", "Anti-inflammatory Agents" and "public health", cruzados pelo operador booleano “AND”. Resultados: A polifarmácia tem se tornado frequente e está relacionada a diversos problemas de saúde, como quedas, dificuldades cognitivas, depressão, desnutrição, infecções resistentes, perda de mobilidade, dificuldades auditivas e visuais, tonturas e até morte precoce. Considerações Finais: Pode-se concluir que a iatrogenia por polifarmáfica pode ser evitada e o uso racional de medicamentos deve ser promovido, além de se estudar e divulgar a vulnerabilidade biológica dos idosos para reduzir esses riscos.
CsRAB, a R2R3-MYB transcription factor from purple tea (Camellia sinensis), positively regulates anthocyanin biosynthesis
Authors: Wu Hualing , Pan Yayan , Ni Erdong , Qin Dandan , Fang Kaixing , Wang Qing , Yang Chengwei , Luo Ming , Liu Jun
Published: December 2024

In tea (Camellia sinensis), anthocyanins are important secondary metabolites that are linked to leaf color. Anthocyanin biosynthesis is a complex biological process, in which multiple genes including structural and regulatory genes are involved. Here, we describe the cloning and characterizing of a new R2R3-MYB transcription factor gene, CsRAB, isolated from purple tea variety ‘Hongfei’. Consistent with its predicted role as a transcription factor, the CsRAB protein localized to nuclei when expressed in onion (Allium cepa) epidermal cell. A dual-luciferase reporter assay demonstrated that CsRAB acts as a transcriptional activator in vivo. CsRAB overexpression in Arabidopsis seedlings led to higher expression levels of anthocyanin biosynthesis-related genes, and consequently, purple stems and higher anthocyanin contents were exhibited in overexpressing lines compared to wild type. The results indicated that CsRAB plays critical roles in positively regulating anthocyanins biosynthesis in tea plants.