bluuebunny/crossref_metadata_2025 huggingface dataset:
Aplicação de Mineração de Dados para Detecção de Potenciais Churns em Empresa do Segmento SAAS
Authors: Lucas de Melo Leonardo , Ballottin Martins Rafael
Published: September 2020

Identify what are the main reasons for losingcustomers isessential for companies that offer subscription services, plans orany other recurring method of payment. The application of datamining techniques may assist to find out patterns that can trace themost likely customers to become churns. Thro ugh this research,using the data mining process, it was possible to identify that,among other factors, the non non-utilization of the main systemmodules and the high default rates corroborates for customers tobecome churn.
A Preliminary Study on the Applied Machine Learning for Detection of the Predominant Factor of Big Five Personality Test
Authors: Da Rocha Henriques Felipe , Christian da Rocha Caio , Fagundes Pereira Diogo , Felipe de Almeida Monteiro Andre
Published: September 2020

Nowadays, the importance of mental health has become an increasinglyrelevant theme. Psychological assessments are part of thedaily life of clinical psychologists in order to identify possible issuesto be explored. Therefore, this work presents a preliminarystudy which aims to evaluate the accuracy of machine learningalgorithms for the detection of the predominant factor of big fivepersonality test. Real answers from a dataset were considered in thecomputational experiments, and two machine learning algorithmswere evaluated: the K-Nearest Neighbors (KNN) and the K-means.Results show that both algorithms could accurately detect the pedominantfactor of the big five test, and KNN obtained better resultsthan the other algorithm.
Gerenciamento de Frequência Escolar Usando Visão Computacional e Redes Neurais Convolucionais
Authors: Almeida Chiquito Eder , Eduardo Rodrigues Guilherme , Becker Julio , Mendes Caroline Mazetto
Published: September 2020

Monitoring students in the classroom plays a key role in the academicfollow-up. In addition to attendance control, it also allowsstudying the impact of absences on learning. In this context, thispaper presents the development of a school attendance managementsystem using computer vision techniques and convolutionalneural networks. A camera captures images from the classroom.The system then detects the faces of the people in the image, andrecognizes students using pre-trained convolutional neural networkmodels. The frequency data generated is stored in the systemdatabase and accessed through a web page. In addition, a mobileapp has been developed to notify student attendance. The initialresults show that the system identifies the registered students andnotifies the mobile device of responsible.
Um Estudo Sobre Meta-Heurísticas em Otimização Multimodal
Authors: Andres Carmona Cortes Omar , Flávio de Jesus Silva Lúcio
Published: September 2020

RESUMOThis paper presents an investigation of four metaheuristics for multimodaloptimization. The algorithms have been implemented inR and compared against each other using well-known benchmarkfunctions. We implemented the following algorithms: Genetic Algorithm(GA), Particle Swarm Optimization (PSO), Differential Evolution(DE), and Bat Algorithm (BA). For comparisons, we used fivemultimodal benchmarks: Rosenbrock, Griewank, Ackley, Schwefel,and Alpine. Preliminary results show that Bat Algorithm and GeneticAlgorithm tend to discover the best solution considering theparameters that have been set up.
A Study on Semantic Segmentation for Autonomous Vehicles
Authors: Almeida dos Santos Vinícius , Lyra Rodrigo , Felski Pereira Thiago
Published: September 2020

Autonomous vehicles are already a reality, and there are still severalchallenges to overcome. One important challenge for the adoptionof these vehicles is perceiving its surroundings. This necessity ofperception can be fulfilled by digital cameras. When working withdigital image processing, the quality will be limited by real-timeconstraints. As several works indicate, this real-time constraint forautonomous vehicles is at most 100ms per frame. Also, by improvingthe processing time, the chances of accidents involving autonomousvehicles may be decreased. This paper analyses the advantages anddrawbacks of semantic segmentation and also presents a study toimplement perception for autonomous vehicles by accelerating asemantic segmentation algorithm, also used by other works on thefield. To accelerate the algorithm, spacial parallelism will be used.
Contando Histórias com Realidade Aumentada
Authors: MatthausBarbosa Fabiann , Kauana da Silva Francisca , NascimentoRodrigues Mizael
Published: September 2020

Nowadays, it is observed that the constant evolution of technology is driving education to new directions, emphasizing the use of new tools and providing effective improvements in the teaching / learning process. Augmented Reality (AR) technology can be a great tool in education, and can also target children with special needs (PNE's). Using AR, the essence and importance of seeking knowledge can reach everyone with more or less needs, and is a useful and innovative tool. Because of this, this research has the proposal to present the development of an AR system, through an interactive textbook telling the story of the municipality of Labrea -AM in a childish way exploring the difficulties of the childrenPNE's, emphasizing the children with autism and cerebral palsy,showing the student's visualization and interaction with abstractknowledge in a complete way and facilitating the way to theunderstanding of theories and concepts.
Jogo para apoio ao ensino-aprendizagem de especificação de requisitos
Authors: Vitor Demaria Venâncio João , Barreto Vavassori Benitti Fabiane
Published: September 2020

Requirements Engineering is concerned with identifying, analyzing,documenting and managing software requirements, which is an importantphase in the software development process. Research showsthat most software design failures are due to requirements engineeringissues. Thus, we propose a solution for the active learningof requirements specification techniques. Considering that the userstory technique is currently well accepted by IT companies, thispaper proposes a mobile game that supports learning and practicein writing user stories.
Sistema Open-Source de Monitoramento do Consumo de Energia Elétrica
Authors: Przysiada† Felipe , Merks Diego , Silva Eduardo , Brawerman Alessandro
Published: September 2020

The cost of electricity in Brazilian homes is increasingly high. This project consists of bringing a complete and easily accessible solution aiming to benefit the economy, in a much broader way, both for the end user and for the electricity generating system, which today has difficulty in meeting demand, as well as it provides a reduction in the environmental impact caused by the constant expansion of hydroelectric plants and other sources of energy. The use of this system, the Electricity Consumption Monitoring System, allows the user to have control of each equipment installed in the premises. The equipment in monitored by a device designed and built in this project. From these monitoring devices, which perform periodic measurements, it is possible to make a daily, weekly or monthly survey of the consumption of each equipment in the residence, sending alert messages, for excessive energy consumption, thus defining a user profile and even creating limitations for monthly spending. With this, the user will have the necessary resources to manage their energy consumption over the days, without having surprises at the end of the month.
Análise de Segurança dos Mecanismos de Consenso no PBFT usando Multichain e PoW usando Ethereum Aplicados em Redes Blockchain Privadas/Consórcio
Authors: Battisti João , Pillon Maurício , Koslovski Guilherme , Miers Charles
Published: September 2020

A considerable number of electronic transaction systems employ classicapproaches based on centralized trust mechanisms, not exploitingthe latest technological advances. Alternatively, the concept ofblockchain stands out, elaborated without the need for this centralizedtrust, but rather dependent on securely chained technologies in whichthe elements involved can conduct secure negotiations. Blockchain isdesigned to address security and distributed system issues through theuse of encryption, algorithms, P2P networks, and consensus mechanisms.This paper presents a Denial of Service (DoS) security analysisof the more traditional Practical Byzantine Fault Tolerance (PBFT)and Proof of Work (PoW) consensus mechanisms available onMultichain and Ethereum solutions based on a private / consortiumblockchain scenario. We present our results of a controlled DoSattack, revealing the importance and need for security-relatedanalysis of blockchain implementations of private / consortiumblockchains.
Roteamento para Estender o Tempo de Vida de Redes de Sensores através de SDN e Caminhos Disjuntos
Authors: Felippe Weber∗ André , Semprebom Tiago , Silveira e Silva Eraldo
Published: September 2020

The recent advances in the application of Software Defined Networks(SDN) concepts in Wireless Sensor Networks (WSNs) leads theimplementation of centralized algorithms. In this work, the SDNconcept is considered, together with two routing procedures, withthe purpose of disjoint paths generation, aiming to extend WSN’slifetime. Both approaches are based on Dijkstra algorithm for theselection of minimum paths. The first approach allocates distinctpaths for various flows towards the same destination. The secondone, penalizes computed paths using an adaptive cost function.Simulation results are performed using the Cooja sensor networksimulator.
Towards a Complete Pipeline for Segmenting Nuclei in Feulgen-Stained Images
Authors: Antonio Buschetto Macarini Luiz , Von Wangenheim Aldo , Perozzo Daltoé Felipe , Sherlley Casimiro Onofre Alexandre , Botelho de Miranda Onofre Fabiana , Ricardo Stemmer Marcelo
Published: September 2020

Cervical cancer is the second most common cancer type in womenaround the world. In some countries, due to non-existent or inadequatescreening, it is often detected at late stages, making standardtreatment options often absent or unaffordable. It is a deadlydisease that could benefit from early detection approaches. It isusually done by cytological exams which consist of visually inspectingthe nuclei searching for morphological alteration. Since itis done by humans, naturally, some subjectivity is introduced. Computationalmethods could be used to reduce this, where the firststage of the process would be the nuclei segmentation. In this context,we present a complete pipeline for the segmentation of nucleiin Feulgen-stained images using Convolutional Neural Networks.Here we show the entire process of segmentation, since the collectionof the samples, passing through pre-processing, training thenetwork, post-processing and results evaluation. We achieved anoverall IoU of 0.78, showing the affordability of the approach of nucleisegmentation on Feulgen-stained images. The code is availablein: https://github.com/luizbuschetto/feulgen_nuclei_segmentation
Ensino de Design Visual de Aplicativos Móveis no Ensino Fundamental
Authors: Nathalie FortunaFerreira Miriam , Gressevon Wangenheim Christiane , Santos Gonçalves Berenice , Carlo Rossa Hauck Jean , Araújo e Silva de Medeiros Giselle
Published: September 2020

Computing in K-12 is typically taught through practicalprogramming activities in which students create software artifactssuch as mobile applications. This approach, however, may notcover other important competencies such as user interface design,which are essential for software development. Within this context,this article presents an instructional unit that incorporates theteaching of UI design competencies into computing education.The instructional unit was developed in a systematic wayfollowing an instructional design process, and applied andevaluated in a Brazilian public middle school. First resultsindicate that dynamics can have a positive impact on motivation,user experience, and provide a significant contribution to thestudents’ learning.
Uma Linguagem de Modelagem de Domínio Específico para Linhas de Produto de Software Dinâmicas
Authors: Borelli Helberth , Teixeira de Carvalho Sérgio
Published: September 2020

Software Product Lines can be briefly defined as a family of productsthat share some commonalities. The feature models approach isused to represent the commonalities and variabilities among products.One possible way for the construction of these models is theuse of meta-models. However, the management of these features,traditionally performed at development time, is not sufficient forthe development of Adaptive Systems. One solution to this type ofdevelopment is the approach of Dynamic Software Product Lineswhich has as one of its aims to promote features input and outputat runtime allowing the product to be adapted after changes incontexts. This article proposes a Domain Specific Modelling Languagethat aims at modeling Dynamic Software Product Lines. Thislanguage describes dynamic adaptations promoted at runtime andthrough the use of the state machine approach. Such adaptations,based on state machines, must promote state features changes orfeatures exchanges at runtime, enabling these software products tomanage derivations in its life cycle. Our proposal was implementedwith the use of a Healthcare scenario and its development wasbased on the concept of the component service model.
Towards Visualizing Code Annotations Distribution
Authors: Lima Phyllipe , Guerra Eduardo , Meirelles Paulo
Published: September 2020

Java developers make extensive use of code annotations sincetheir introduction in version 5 of the language. They areinserted directly on the source code for custom metadata configuration,similar to C# attributes. The software engineeringcommunity has few works investigating their usage and impacton source code. Being able to visualize characteristics ofcode annotations might aid developers in detecting potentialmisuse, outliers as well as increase the comprehensibility andreadability of the source code. In this paper, we present anapproach to use software metrics to generate a 2D polymetricview targeting the visualization of code annotations in Javaclasses. We developed a prototype tool using the Unity GameEngine. It displays classes and packages as rectangles andannotations as circles. We demonstrated the tool with a smallsample Java program.
Conversational Agents for the Elderly, the Guardian Platform
Authors: Ferreira Andressa , Oliveira Fran , Damasceno Adson , Cortés Mariela
Published: September 2020

With increasing of life expectancy innovative solutions that ensurewell-being of the seniors become most needed. In this context, inorder to deny the main difficulties reported by the senior public withthe use of mobile devices, we propose a technology entirely basedon voice interactions and we name this project of Guardian. Theessence of the project is to provide, through a mobile application, aplatform with a set of intelligent agents focused on the well-beingof the older adults. In this work the mains objectives to analyze andevaluate the usability of the Guardian and the cultural impacts ofthe technology. For the data collection, video recordings were used,a questionnaire that identifies the socio-technological profile of theresearch participants and the system usability scale (SUS).
Smart Water:A Prototype for Monitoring Water Consumption
Authors: Hoeltgebaum Pereira Eduardo , Faustino Hoppe Aurélio , Alexandre Wisintainer Miguel
Published: September 2020

The traditional metering system of water meters, through human readers, although still widely used by companies that provide water service, tends to become an increasingly unviable process over the years, due to urban growth. With the objective of finding a solution to this question, this paper presents the development of a prototype to monitor water consumption and an application that allows the end user to visualize his consumption. For the prototype, it was used the NodeMCU module, because of it being a low-cost device, along with a Wisol WSSFM10R2 Breakout module, which allows communication through the Sigfox network, considered an alternative network for IoT communications, using simple AT commands, besides the Sigfox company provide all the architecture for the developer. The present work also discusses about how the Sigfox hardware and network works, explaining the pulse conversion processes emitted by the flow and pressure sensors, as well as the use of the NodeMCU module for control and sending of messages through the Sigfox network. In general, the prototype obtained a satisfactory result in relation to the calculation of water consumption, reaching accuracy rates above 90% in tests that used the values returned by both sensors in constant flows and an average accuracy rate of around 99% for tests with varied flows, where it has been proven that the use of the pressure sensor optimizes the consumption calculation.
MFID: uma Solução Computacional para a Identificação da Fadiga Muscular Durante a Reabilitação Física de Indivíduos Amputados
Authors: Teixeira Paiva Bryan , Domingues Saraçol Júnior Julio , Marcelo Hoff do Amaral Érico , Follmann Jone
Published: September 2020

It’s know that computing is becoming increasingly integrated intoother knowledge areas, providing practical and innovative solutionsto many types of problems, including to health care area. Inthis sense, the amputatee patients physical rehabilitation processalso shows as an important area for tools development that assistthe professional physiotherapist, since this rehabilitation processis long-lasting and exhaustive for patients. Thus, the present workdescribes the development of a solution called Muscle Fatigue Identifier(MFID) to improve the amputee physical rehabilitation process,by detecting muscle fatigue during physical exercise sessions,which once unidentified, can cause injury and pain to patients,further prolonging treatment. The developed system consists inthe integration of sensors, hardware and software. This way, it waspossible to monitoring and identify the muscle fatigue occurrenceduring the physical exercise sessions performed by the patients, aswell as allowing a use tool to evaluate the physiotherapy treatment.
L-SHADE with Alternative Population Size Reduction for Unconstrained Continuous Optimization
Authors: Renkavieski Christopher , Stubs Parpinelli Rafael
Published: September 2020

Differential Evolution (DE) is a powerful and versatile algorithmfor numerical optimization, but one of its downsides is its numberof parameters that need to be tuned. Multiple techniques have beenproposed to self-adapt DE’s parameters, with L-SHADE being oneof the most well established in the literature. This work presentsthe A-SHADE algorithm, which modifies the population size reductionschema of L-SHADE, and also EB-A-SHADE, which applies amutation strategy hybridization framework to A-SHADE. Thesealgorithms are applied to the CEC2013 benchmark set with 100dimensions, and it’s shown that A-SHADE and EB-A-SHADE canachieve competitive results.
Analisando Tweets Relacionados a Deficiências: uma Abordagem Baseada em Classificação
Authors: Baségio Junior Ademir , Darlindo Freitas Rodrigues Lucas , Fernando Lavareda Jacob Junior Antonio , Manoel França Lobato Fábio
Published: September 2020

Approximately 80 % of people with some form of physical, mental,or intellectual disability live in developing countries. These samecountries have shown significant growth in the availability of theinternet. Such facts reveal good possibilities regarding access toemotional support and experiences exchange among people withdisabilities through social media. However, hate speech and derogatorycomments about these people can be a recurring problem onthese platforms. In order to identify these posts, this article featuresa classifier developed using Twitter posts related to disabilities.The results show that the tool developed is promising in detectingoffensive and pejorative comments on this topic, which can be usedin content management systems.
O Uso do Endereço de Email pelos Sites mais Acessados pelo Público Brasileiro e os Possíveis Impactos na Privacidade de Seus Usuários
Authors: Ribeiro de Mello Emerson , Aparecida de Chaves Shirlei
Published: September 2020

More and more online businesses are using the email for a purposeother than its original one, which was to enable communicationbetween people. Email address is used as a user account identifierand systems send transactional messages to their user’s emailaddresses. This paper presents an analysis of the user’s accountregistration process in the main online businesses used by Brazilianpeople in 2018. It has been found that the exclusive use of emailas account identifier is the most used option and that the greatmajority does not verify if the email informed during the registrationprocess really belongs to the requesting user. Along with thefindings discussion, we outline some measures that could be usedby these businesses to reduce the negative impact to users privacy.
Um Framework para Gerenciamento de Notificações em Dispositivos Móveis e Interações Agendadas em SistemasWeb
Authors: Cavalcante da Silva Joab , Augusto Dantas Laurentino
Published: September 2020

Mobile notifications are clickable messages commonly used to attractusers’ attention at specific times and in different contexts.Among other uses, scheduled notification interventions are toolsthat can remind users of something important or recommend informationthat may be needed. Using notifications to promote interactionbetween web-based systems and mobile users has becomecommon practice. However, there are still challenges related tomanaging these notifications, such as knowing which notificationswere acknowledged and triggered by users, or enabling them toidentify ignored notifications. In this article, we introduce ’ResolveNotification’, a framework that supports scheduling notificationson smart devices. Our solution enables the creation of features thatmake it easy for web system developers to generate notifications,and for individualized management of notifications and interactionsscheduled by system administrators as well as mobile end users.We tested the framework with developers and employed the systemin a preliminary educational case study - the results suggest that’Resolve Notification’ has the potential to be used for managingweb and mobile notification systems.
Genetic Algorithm in Survival Shooter Games NPCs
Authors: Steffens Henrique Alisson , Martins Brasil Soares Ricardo , Luis Scaranto Dazzi Rudimar , Lyra Rodrigo
Published: September 2020

Games must engage players by keeping them in the game flow. Tobetter define the game difficulty according to the player, GeneticAlgorithms can be used. One of the interesting characteristics ofGenetic Algorithm is that it is a non-deterministic algorithm. For theplayer’s vision, it means that enemies are unpredictable. By notknowing which NPCs he will face, the gameplay turns moreinteresting. Another amusing factor for gaming is its adaptability,causing NPCs to slowly struggle to find a way to beat the player. Thesetwo characteristics make Genetic Algorithms good tools to makegames more entertaining. This paper aims to demonstrate thisadaptation capability in the Survival Shooter, developed by Unityenterprise and modified by the author for the algorithmimplementation. As result, it shows that players could stay in the gameflow while playing against genetically modified enemies.
Reconhecimento de Padrões em Imagens de Triatomíneos Usando Redes Neurais Artificiais com Algoritmo Backpropagation
Authors: Marcelino Pacheco Neto Joao , Noura Teixeira Otavio
Published: September 2020

Chagas disease, also known as American trypanosomiasis isone of the consequences of the human infection caused by theflagellate protozoan called Trypanosoma cruzi transmittedby the barbeiro of the subfamily Triatominae known as triatomines.In the Lower Tocantins region of the state of Para,three genera of barbers transmitting the disease are found.Searching for a way to automate the manual recognition process,this work aimed to implement a Model of Recognitionand Classification of Images of barbers found in the LowerTocantins region in order to recognize the genus of the insectthrough the use of Artificial Neural Networks PerceptronMulti-layered and performing training with Backpropagationalgorithm, helping to identify the transmitters. In themiddle of this recognition, the Digital Image Processing isperformed to extract important characteristics relevant to theclassification. This entire process is performed in MATLABsoftware through scripts and the creation of the ArtificialNeural Network in the toolbox called Pattern RecognitionApp.
REACT-M: uma Abordagem Ágil para o Gerenciamento de Requisitos de Software
Authors: Vale da Silva Bleno Wilson Frankiin , Anjos Lima Aline Franciele dos , Bezerra Oliveira Sandro Ronaldo , Coelho Pinheiro André Luiz
Published: September 2020

Agile methods provide support to software engineeringactivities, aiming to reduce some of problems of the traditionalapproaches. Quality products can be developed by agilemethodology in less time and budget. Requirements engineeringis a building block of software development. Therefore, thesearch for agile practices for the evolution of requirementsbecomes relevant. Although several researches have been carriedout on the role of requirements engineering in agilemethodologies, there is still a need for studies that seek to alignagile approaches to requirements development and managementprocesses that satisfy highly accepted quality models in themarket. This paper aims to establish an agile approach tosupport software requirements management, based on asystematic literature mapping that draws on existing approachesin agile methodologies that support requirements managementactivities.
Comunidades Amazônicas Revivendo Experiências na Terceira Idade em Realidade Virtual no Interior do Amazonas
Authors: Vitória Duarte Nogueira Bárbara , Matthaus Dantas Barbosa Fabiann
Published: September 2020

Today, technology is present in the life of much of society, offering different forms of interaction, showing new ways of understanding, perception and learning. However, in the daily life of the elderly there are still barriers that hinder digital inclusion, this becomes clearer in places where technology is not evident, such as in the interior of the Amazon. The use of virtual reality (VR) has grown in society in different segments, so that its application has brought new immersive experiences in various areas. With the objective of expanding digital inclusion with older people living in Labrea - AM, this project aimed to provide the elderly population in rural and riverside communities with opportunities to reconstruct memories lived in the past through old images experiencing new experiences in a three-dimensional manner. through virtual reality. For this, cardboard scrap collections were made for the creation of VR glasses, as well as the making of devices using recycled materials. With this, the project was able to serve as a benefit in the reconstruction of experiences located in time, space and the whole of social relations, besides being a guide of information and exchange of experiences transmitted to the younger ones.
Turistando CG
Authors: Muzzi de Lamare Paz Annie , Santos Sá Laíza , Fernando Delboni Lomba Luiz
Published: September 2020

It is known that Brazil is a country with great tourism potential, due to its enormous cultural and natural diversity. However, this potential is not fully exploited, as observed in the city of Campo Grande. Even located on the route of the main tourist attractions of the state of Mato Grosso do Sul, the city is not recognized for its tourist attractions. Having knowledge of this scenario, brings the proposal of Turistando CG, with the objective of disseminating the tourist activities of Campo Grande, from a tourist inventory built to feed a web system, developed to disseminate the data of tourist activities.
Praticando a Extensão para Promover Inclusão Digital com Computação Desplugada e Pensamento Computacional
Authors: Da Silva Bobsin Rafaela , Silveira Batista Vithória , De Souza Fabrício Vitória , Bernardo Nunes Natália , Lemke Kologeski Anelise
Published: September 2020

This work presents a practical experience that offers playful workshops with plugged and unplugged computing, including logical reasoning, computational thinking and basic programming concepts. The main objective is to attend students in the final grades of elementary school, providing digital inclusion. The activities were developed with 440 participants, from 18 different institutions, between 2017 and 2019 years. The results shown improvements in the understanding of statements related to the worked themes by up to 45%. In addition, digital inclusion has been provided through information and digital communication technologies applied in education, providing a great playful moment for all people involved.
Desenvolvimento de um Protótipo Automatizado de Detecção e Focalização de Raios Solares com Hardware Livre
Authors: Soares de Santana Filho Orlando , Henrique Mota Martins Carlos , Henrique Felix C. Ribeiro Conceição Thiago , Vinicius dos Reis Freitas Silva Alex , Honorato Braga Adriano , Bonacin Braga Ramayane
Published: September 2020

Solar energy is a renewable and inexhaustible source, besidescausing damage to nature, being clean and sustainable.Transform the electromagnetic radiation emitted by the Sunelectrical energy are used solar panels. In order to improveefficiency and performance of this capture, a low-cost wasbuilt, a single-axis solar tracking system for photovoltaicpanels. The solution uses the automation Arduino UNO R3,open hardware, two photosensitive sensors LDR GL-5528, inaddition to a servo motor capable of moving the surface of aphotovoltaic plate according to the detection of the highestincidence of light. The circuit and its components wereprogrammed using the Arduino IDE software, version 1.8.11.As a result, it was possible to follow the movement of thesun, differing from a static panel, thus ensuring greater sunshineon the solar plate, as a result of this traceablecontrol prototype.
Analyzing ingrowth using zero-inflated negative binomial models
Authors: Lappi Juha , Pukkala Timo
Published: September 2020

Ingrowth is an important element of stand dynamics in several silvicultural systems, especially in continuous cover forestry. Earlier predictive models for ingrowth in Finnish forests are few and not based on up-to-date statistical methods. Ingrowth is here defined as the number of trees over 1.3 m entering a plot. This study developed new ingrowth models for Scots pine ( L.), (Picea abies (L.) H. Karst.) and birch ( Roth and Ehrh.) using data from the permanent sample plots of the Finnish national forest inventory. The data were over-dispersed compared to a Poisson process and had many zeros. Therefore, a zero-inflated negative binomial model was used. The total and species-specific stand basal areas, temperature sum and fertility class were used as predictors in the ingrowth models. Both fixed-effects and mixed-effects models were fitted. The mixed-effects model versions included random plot effects. The mixed-effects models had larger likelihoods but provided biased predictions. Also censored prediction was considered where only a certain maximum number of ingrowth trees were accepted for a plot. The models predicted most pine ingrowth in pine-dominated stands on sub-xeric and xeric sites where stand basal area was low. The predicted amount of spruce ingrowth was maximized when the basal area of spruce was 13 m ha. Increasing temperature sum increased spruce ingrowth. Predicted birch ingrowth decreased with increasing stand basal area and towards low fertility classes. An admixture of pine increased the predicted amount of spruce ingrowth.Pinus sylvestrisNorway spruceBetula pendulaB. pubescens2â1
RP-UPLC Stability Indicating Assay Method for Simultaneous Estimation of Dextromethorphan Hydrobromide and Chlorpheniramine Maleate in Tablet Dosage Form
Authors: Patel A.J. , Patel N.K. , Vyas A.J. , Patel A.B. , Patel A.I.
Published: September 2020

RP-UPLC method was developed and validated for the determination of chlorpheniramine maleate and dextromethorphan hydrobromide in tablet dosage form. Reverse phase waters acquity UPLC BEH C18 (50 mm × 2.1 mm, 1.7 μm) column using isocratic mobile phase of 0.5 mL 0.1% TFA (trifluroacetic acid) in H2O:CH3CN (70:30 %v/v). The flow rate was 0.2 mL/min and 252 nm wavelength use for detection on PDA detector. The retention time of chlorpheniramine maleate was 1.2 min and 2.2 min for dextromethorphan hydrobromide. Chlorpheniramine maleate and dextromethorphan hydrobromide was subjected to stress conditions including acidic, alkaline, oxidation, photolysis and thermal degradation. The method was validated as per ICH guideline with respect to samples to specificity, precision, accuracy, linearity and robustness.
Stability Indicating RP-UPLC Photo-Diode Array based Method for Determination of Edoxaban Tosylate
Authors: Patel D.M. , Rana B. , Maru S. , Vyas A.J. , Patel A.B. , Patel A.I. , Patel N.K.
Published: September 2020

The objective of the current study was to develop a specific, precise, accurate and robust gradient stability indicating reversed-phase ultra performance liquid chromatography (RP-UPLC-PDA) assay method and validated for determination of edoxaban tosylate in API. Gradient separation was achieved on an acquity UPLC BEH C18 column (50 mm, 2.1 mm and 1.7 μm) column using mobile phase of acetoitrile:20 mM potassium dihydrogen phosphate, pH 3.0 ± 0.05 adjust with OPA at flow rate of 0.6 mL/min, the injection volume was 1 μL and the detection was carried out of 289 nm by using photo-diode array detector. The drug was subjected to oxidation, hydrolysis, photolysis, and heat to apply stress condition. The method was linear in the drug concentration range of 100-300 μg/mL with correlation coefficient of 0.999. Degradation products produced as a result of stress studies did not interfere with detection of edoxaban tosylate and the assay, thus developed stability indicating method can be used for routine analysis in pharmaceutical industry.
Design, Synthesis and Evaluation of Aryloxybenzylidene Hydrazinyl-Benzoxazoles/Benzothiazoles Analogs as Antimycobacterial Agents
Authors: Aruna G. , Kulkarni Ravindra , Machaa Baswaraj , Jojula Malathi , Gunda Shravan , Achaiah G.
Published: September 2020

Substituted 2-(2-(4-aryloxybenzylidene)hydrazinyl)benzothiazole/benzoxazoles series were designed through molecular hybridization and synthesized in condensation reaction of hydrazinylbenzothiazole/benzoxazole with substituted aryloxy benzaldehydes. All the synthesized compounds were assigned structure based on spectral data and were evaluated for antimycobacterial activity. Among both benzothiazole and benzoxazole derivatives, the compounds 8f and 9e were found to show most potent antitubercular activity with MIC value of 0.89 and 0.92 μM which are on a par with those of standard antitubercular drugs. In order to know the binding interactions of all the compounds were docked within the mycobacterial pantothenate synthetase, which showed interactions with Asp88, Arg200, Ser196, Asn199, Met 195 and Lys 160 of pantothenate synthetase.
Development and Validation of Stability Indicating Method for Simultaneous Estimation of Esomeprazole and Levosulpiride by HPTLC using Experimental Design
Authors: Pandey M.M. , Prajapati K.B. , Vyas A.J. , Patel A.M. , Patel N.K. , Patel A.I. , Patel A.B. , Chudasama A.
Published: September 2020

The present study examines simultaneous multiple response optimization using desirability function for the development of an HPTLC method to detect esomeprazole magnesium trihydrate and levosulpiride in pharmaceutical dosage form. HPTLC separation was performed on aluminium plates pre-coated with silica gel 60 F254 as the stationary phase using ethyl acetate:methanol:toluene:ammonia (7:1.5:1.5:0.1% v/v/v) as the mobile phase. Full factorial design applied for the optimization of degradation condition. Esomeprazole magnesium trihydrate and levosulpiride were subjected to acid, alkali hydrolysis, oxidation and photodegradation. Experimental full factorial design has been used during forced degradation to determine significant factors responsible for degradation and to optimize degradation conditions reaching maximum degradation. 32 and 23 full factorial design has been used for optimization of chromatographic condition in acid and base degradation study, respectively. Quantification was achieved based on a densitometric analysis of esomeprazole magnesium trihydrate and levosulpiride over the concentration range of 800-4000 ng/band and 1500-7500 ng/band, respectively at 254 nm. The method yielded compact and well-resolved bands at Rf of 0.70 ± 0.02 and 0.32 ± 0.02 for esomeprazole magnesium trihydrate and levosulpiride, respectively. The linear regression analysis for the calibration plots produced r2 = 0.9967 and r2 = 0.9981 for esomeprazole magnesium trihydrate and levosulpiride, respectively. Method is validated as per ICH (Q2)R1 guideline.
Computational, Experimental Structural Characterization and Molecular Docking Studies of 5,7-Dihydroxy-4-methoxyflavone against Cytochrome P450 Enzymes
Authors: Harikrishnan A. , Madivanane R.
Published: September 2020

In this work, the geometry optimization and harmonic vibrational wavenumbers of kaempferide (5,7-dihydroxy-4-methoxyflavone) were computed by density functional theory (DFT) method. Theoretically computed vibrational wavenumbers were compared with experimental values and the interpretation of the vibrational spectra has been studied. Frontier molecular orbitals (FMO) and molecular electrostatic potential (MEP) analysis of the title compound have been carried out. The 1H & 13C NMR, UV visible and electronic properties of the compound were investigated theoretically and compared with the experimental values. Molecular docking study of the compound against cytochrome P450 family enzymes (CYPs 1A1, 1A2, 3A4, 2C8, 2C9 and 2D6) were also studied and the results revealed that the title compound interact with human CYP2C8 enzymes with minimum binding energy of -9.43 kcal/mol. The compound forms hydrogen bond with the residues of Thr302, Thr305, Leu361, Val362, Cys435, Gln356 and Ala297. Thus, these studies assist to understand the inhibitory mechanism of kaempferide with CYP450 enzymes and may facilitate significant clinical implications in the prevention and treatment of various therapeutic diseases.
Synthesis of Fluorinated Piperazinyl Substituted Quinazolines as Potential Antibacterial Agents
Authors: B. Patel Amit , Patel Purvesh , Patel Kajal , Prajapati Krupa
Published: September 2020

In present study, fluorinated piperazine and benzonitrile/nicotinonitrile fused quinazoline derivatives have synthesized, characterized using FT-IR, 1H & 13C NMR, 19F NMR and MS analysis and evaluated as potential antibacterial agents. They were also tested against the multidrug resistant strains. The antibacterial activity results revealed that the majority of synthesized compounds exhibited potential antibacterial with the extraordinary level of minimum inhibitory concentrations comparable to the control drugs. Moreover, the influence of presence or absence of fluoro and trifluoromethyl functional groups on the piperazine ring systems towards different biological species is elaborated. The synthesized compounds were also found non-toxic on the human cervical (HeLa) cells at their minimum inhibitory concentrations.
The Chemical Sciences' Advances on Coronavirus Disease 2019 (COVID-19)
Authors: Mondal Shovan
Published: September 2020

The novel β-coronavirus (SARS-CoV-2) causes coronavirus disease (COVID-19), which is presently a pandemic affecting numerous nations worldwide including a grim fatality of over 9 lakhs deaths till August, 2020. But even after the 9 months of the outbreak of this deadly disease, there is no particular medication or vaccine so far that can be recommended for the treatment of COVID-19 patients. Therefore, chemists are struggling to understand and dissect the viral structure of this SARS-CoV-2, unwind its pathogenesis and pinpoint its vaccines and therapies as well. In this current study, the author endeavor to sum up the ongoing advances of chemical sciences about COVID-19 focusing mainly on the developments of its therapeutics.
Molecular Docking Studies of Some Natural Products Against SARS-CoV-2 Main Protease: Potential Therapeutic Agents for COVID-19
Authors: Sadhasivam Gnanavel
Published: September 2020

The severe form of respiratory disease (COVID-19), caused by SARS-COV-2 virus, has evolved into a pandemic is the defining global health crisis of our time and greatest challenge we have faced since second World War. Hence, the current situation demands an immediate need to explore all the possible therapeutic strategies that can be control spread of the diseases. We identified potent COVID-19 Mpro inhibitors based on molecular docking studies on 24 known antiviral natural compounds, which are from medicinal plants and marine sponges. The results revealed that 15 potential COVID-19 main protease inhibitors have been identified among the 24 natural compounds of plants and marine origin. The result further revealed that the selected natural products that has lower free binding energy is Halituline (-8.41 Kcal/mol). As these active compounds were extensively validated by molecular docking, the chance that at least few of these compounds could be bioactive is excellent.
Non-Nucleoside HIV-1 Reverse Transcriptase Inhibition Activity of a Series of Dihydroalkoxybenzyloxopyrimidine (DABO) Derivatives: CoMFA, CoMSIA and Docking Studies
Authors: Kumar Sarkar Bikash , Sarkar Ananda , Dipankar Jana Atish
Published: September 2020

CoMFA, CoMSIA and molecular docking studies have been carried out for a set of 42 dihydroalkoxybenzyloxopyrimidine (DABO) derivatives for which anti-HIV activity values are available. In 3D-QSAR studies-comparative molecular field analysis (CoMFA) as well as comparative molecular similarity indices analysis (CoMSIA) have been performed. Both the QSAR model nicely explains the inhibitory activities of DABO derivatives as well as provides molecular level insights revealing which regions in 3D space around the molecules are more important for their anti HIV-activities. These models have a quite high square correlation coefficient (r2 = 0.817 for CoMFA and r2 = 0.943 for CoMSIA). A docking study of the highest active molecule into the binding site of the protein HIV-1 RT (PDB ID-1RT1) shows that hydrogen bonding between pyrimidine moiety of the ligand and the Lysine-101 moiety along with Valine-106 moiety of the HIV protein play most important role for stabilizing the ligand in the binding pocket of the protein.
Estudo bibliométrico da produção científica sobre a temática "preservação documental dos acervos em bibliotecas"
Authors: Arabidian Lizandra Veleda , Cademartori Cristina Vargas , Beneduzi Anelise
Published: September 2020

A evolução da produção científica sobre o tema “preservação documental em bibliotecas” no período de 1991 a 2018, foi avaliada através de um estudo bibliométrico. A preservação dos acervos é um tema relevante, particularmente no que se refere ao suporte em papel e seus respectivos agentes de deterioração nas bibliotecas, uma vez que muitos dos acervos são tratados como patrimônio cultural e testemunhos de memória. Como método, adotou-se a análise de conteúdo e, como campo empírico, a produção científica da área. Os resultados foram obtidos através de uma busca sistemática realizada no Portal de Periódicos da CAPES, seguindo-se o protocolo Prisma. Os descritores utilizados na busca foram library, fungi, microorganism, documentary preservation, microbial environmental monitoring, biodeterioration, collection, bacterium, bem como seus correspondentes em língua portuguesa. Foram obtidos 64 resultados relevantes, filtrados pelo título, resumo e palavras-chave, 62 dos quais compreenderam artigos publicados em 39 periódicos nacionais e internacionais, 1 capítulo de livro e 1 livro. Os termos mais frequentes foram preservação, fungos, biblioteca e biodeterioração. A revista que concentrou o maior número de artigos foi a “International Biodeterioration & Biodegradation”. No recorte temporal analisado, houve um aumento da produção a partir do ano de 2008, com ápice em 2016. Os periódicos internacionais aglutinaram 72% das publicações, em sua maioria, na categoria Qualis B. A busca totalizou, ainda, oito dissertações de mestrado acadêmico e seis trabalhos de mestrado profissionalizante, desenvolvidos em oito instituições de ensino superior, com destaque para a UFSM (cinco dos 14 trabalhos). As áreas de Ciências Sociais e Humanidades, e Ciência da Informação foram as que concentraram o maior número de trabalhos em nível de mestrado, 35,7% e 28,6%, respectivamente. O ano de 2016 também apresentou um número relevante de ocorrências de dissertações sobre o tema. Evidenciou-se um aumento da produção científica sobre a temática de preservação de acervos nos últimos anos e isso, provavelmente, tem contribuído para informar e conscientizar sobre a importância da preservação documental.
Comunicação científica
Authors: Santos Ana Claudia de Araújo , Alves Edvaldo Carvalho
Published: September 2020

Esta pesquisa teve como objetivo realizar um levantamento bibliográfico sobre a esquistossomose, em relação ao período de 1940 a 1949, em que se concentrou a maior produção de trabalhos, desde a descoberta da doença, no território nacional, até o aumento da contaminação da população por essa verminose. Para atingir esse objetivo, foi desenvolvida uma pesquisa descritiva, de abordagem qualiquantitativa, de natureza documental. O corpus de análise foi de 186 artigos de periódicos nacionais. Constatou-se que o Instituto Oswaldo Cruz teve um papel preponderante no desenvolvimento de pesquisas e expedições científicas voltadas para combater essa endemia e no desenvolvimento de uma ciência experimental.
Conciliar Trinitarianism, Divine Identity Claims, and Subordination
Authors: Pawl Timothy
Published: September 2020

In this article, I present the trinitarian teaching of the first seven ecumenical councils, what we might call Conciliar Trinitarianism. I then consider two questions. First, what is the relationship between the divine persons and the divine nature? I argue that neither strict identity nor instantiation interpretations of that relationship fit well with the conciliar texts. Second, does the relation of procession among the divine persons, asserted in the conciliar texts, imply an objectionable ontological subordination in the Trinity? I argue that there is at least one way for a proponent of Conciliar Trinitarianism to deny that objectionable ontological subordination follows from the divine processions.