bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH ONLINE PROMOTION TERHADAP REPURCHASE INTENTION DENGAN CONSUMER PERCEPTION SEBAGAI MEDIASI PADA TRAVEL ONLINE
Authors: Adelia Stefanie
Published: April 2019

Marketing strategies such as online promotion are now mostly done to attract customer repurchase intention to online travel services by establishing a good consumer perception. Online media is chosen as a media campaign because it is able to reach a very broad market segment and not limited to time with a relatively low cost and can form a consumer perception that affects the consumer's buying interest. Research on the influence of online promotion on repurchase intention with consumer perception as mediation on online travel is done to 100 online travel online buyers selected by non-probability sampling with WarpPLS data analysis technique. The results showed that online promotion has a positive effect on repurchase intention directly and repurchase intention positively indirectly influence through the mediation variable consumer perception. This study proves that consumer perception can be a good mediation between online promotion and repurchase intention
PENGARUH LOGO KEMASAN PRODUK KOSMETIK SEBAGAI PENJELASAN KRITERIA PRODUK PEMAKAIAN DAN TINGKAT PENGETAHUN KEMASAN PRODUK TERHADAP REPURCHASE INTENTION (STUDI KASUS IBU-IBU / REMAJA CAKRAWALA II TJ PRIOK, KEC. KOJA JAKARTA UTARA)
Authors: Ramadhayanti Ana
Published: April 2019

Semakin banyaknya produk kosmetik yang berkembang dimasyarakat secara tidak langsung  membuat konsumen ingin mencoba produk tersebut. Sampai saat ini produk kosmetik yang berkembang dimasyarakat beberapa diantaranya tidak  memiliki logo atau simbol pada produk kemasan. Namun meskipun terdapat logo dikemasan terkadang ada beberapa konsumen yang tidak mengetahui arti dari logo atau symbol yang tertera dikemasan kosmestik tersebut. Padahal pencantuman simbol atau logo tersebut pada dasarnya  sangat penting terutama untuk mengetahui kandungan yang terdapat pada produk, masa kadarluwarsa, kemasan produk berbahan ramah lingkungan atau tidak, dan cara penggunaan dari produk tersebut. Tujuan penelitian ini pada dasarnya untuk mengetahui pengaruh Logo Kemasan Produk Kosmetik Sebagai Penjelasan Kriteria Produk Pemakaian Dan Tingkat Pengetahun Kemasan Produk Terhadap Repurchase Intention. Penelitian ini menggunakan tipe penelitian survei, sedangkan metode penelitian yang digunakan adalah kuantitatif. Berdasarkan hasil penelitian didapatkan keseimpulan bahwa Logo Kemasan Kosmetik berpengaruh secara positif dan signifikan terhadap Repurchase Intention. Sementara itu untuk Pengetahuan berpengaruh positif  dan signifikan terhadap Repurchase Intention. Diharapkan dari hasil penelitian ini masyarakat akan lebih waspada dan cermat sebelum membeli produk kosmetik
Associations of Joint Line Tenderness and Patellofemoral Grind With Long‐Term Knee Joint Outcomes: Data From the Osteoarthritis Initiative
Authors: Wang Yuanyuan , Teichtahl Andrew J. , Wluka Anita E. , Pelletier Jean‐Pierre , Abram François , Martel‐Pelletier Johanne , Cicuttini Flavia M.
Published: April 2019

Objective

To examine whether joint line tenderness and patellofemoral grind from physical examination were associated with cartilage volume loss, worsening of radiographic osteoarthritis, and the risk of total knee replacement.

Methods

This study examined 4,353 Osteoarthritis Initiative participants. For each measurement of joint line tenderness and patellofemoral grind, the patterns were defined as no (none at baseline and at 1 year), fluctuating (present at either time point), and persistent (present at both time points). Cartilage volume loss and worsening of radiographic osteoarthritis over 4 years were assessed using magnetic resonance imaging and radiographs, and total knee replacement over 6 years was assessed.

Results

A total of 35.0% of participants had joint line tenderness, and 15.8% had patellofemoral grind. Baseline patellofemoral grind, but not joint line tenderness, was associated with increased cartilage volume loss (1.08% per year versus 0.96% per year; P = 0.02) and an increased risk of total knee replacement (odds ratio [OR] 1.55 [95% confidence interval (95% CI) 1.11–2.17]; P = 0.01). While the patterns of joint line tenderness were not significantly associated with joint outcomes, participants with persistent patellofemoral grind had an increased rate of cartilage volume loss (1.30% per year versus 0.90% per year; P < 0.001) and an increased risk of total knee replacement (OR 2.10 [95% CI 1.30–3.38]; P = 0.002) compared with those participants without patellofemoral grind.

Conclusion

Patellofemoral grind, but not joint line tenderness, may represent a clinical marker associated with accelerated cartilage volume loss over 4 years and an increased risk of total knee replacement over 6 years. This simple clinical examination may provide clinicians with an inexpensive way to identify those at higher risk of disease progression who should be targeted for surveillance and management.
Bleeding incidence and risk factors among cancer patients treated with anticoagulation
Authors: Angelini Dana E. , Radivoyevitch Tomas , McCrae Keith R. , Khorana Alok A.
Published: April 2019

Compared to age‐matched controls, cancer patients have increased risk of bleeding when treated with anticoagulation. However, there are little data regarding bleeding as it relates to anticoagulant choice and other risk factors. We evaluated the six‐month incidence of bleeding among patients treated with anticoagulation who had bleeding risk factors. Data were obtained from Explorys (IBM Watson, Inc.), which pools data from multiple US healthcare organizations. Cohorts of patients were created to compare bleeding events between cancer and non‐cancer patients treated with anticoagulation within six months of starting anticoagulation. Potential bleeding risk factors such as cancer type, metastatic disease, obesity, chronic kidney disease stage III or higher, and platelet count were evaluated. We compared ratios of numbers of patients in specific cohorts using chi‐squared tests with continuity correction. The cohort comprised 3 283 140 cancer patients, of whom 435 140 (13.3%) received anticoagulation within six months of their cancer diagnosis. Bleeding incidence was higher in cancer vs non‐cancer patients across all anticoagulants studied: warfarin 20.2% vs 12.6%, rivaroxaban 16.7% vs 12.1%, LMWH 13.2% vs 9.7%, and apixaban 14.5% vs 9.3%, P < .001 for all comparisons. Among all anticoagulants except warfarin, we found increased bleeding incidence in cancer patients with metastatic disease, gastrointestinal primary, CKD ≥ stage III, and platelets <100,000 × 109/L. Bleeding incidence was higher in cancer patients regardless of the anticoagulant used. Patients with gastrointestinal malignancies had a higher incidence of bleeding compared to other tumors across all anticoagulants. Other factors associated with increased risk of bleeding included metastatic disease, chronic kidney disease, and thrombocytopenia.
Platinum(II) complexes containing hydrazide‐based aminophosphine ligands: Synthesis, molecular structures, computational investigation and evaluation as antitumour agents
Authors: Gholivand Khodayar , Maghsoud Yazdan , Kahnouji Mohammad , Hosseini Mahdieh , Satari Mohammad , Abdolmaleki Parviz , Roe Stephen Mark
Published: April 2019

Four new N,N‐bis(diphenylphosphino)amine ligands (where amine = 1‐amino‐4‐methylpiperazine (L1), N‐aminophthalimide (L2), 4‐aminomorpholine (L3) and hydrazine dihydrochloride (L4)) and their Pt(II) complexes C1, C2, C3 and C4 were synthesized and characterized using infrared and NMR spectroscopies. The crystal structures of C1, C2 and C3 were determined using single‐crystal X‐ray diffraction techniques. The antitumour activities of the synthesized complexes determined using MTT assay on MDA‐MB‐231 cell line revealed that the studied complexes, especially C2, significantly suppressed the proliferation of these cancer cells in a dose‐ and time‐dependent manner (e.g. at a complex concentration of 100 μg ml−1, in 24 h, the reduction of the cell viability was 88.00, 38.89, 83.35 and 64.28% for C1–C4, respectively). Theoretical approaches were also used to investigate the energy and the nature of metal–ligand and metal–chlorine interactions in the complexes, which could explain their biological activities. Results demonstrated that the interaction between ligand and Pt is stronger in C2, while the Pt–Cl interaction is weaker in this complex in comparison with the other complexes.
Fluorescence analysis of polyaromatic hydrocarbon photodegradation in the presence of polypropylene microfibers
Authors: Tchaikovskaya O.N. , Kraukhina V.S. , Artjyshin V.R. , Petrova A.Yu.
Published: April 2019

In this study, degradation of naphthalene and anthracene in water using ultraviolet (UV) light in the presence of polypropylene microfibers (PPM) modified with TiO2 was investigated using fluorescence analysis. KrCl (λrad = 222 nm) and XeCl (λrad = 308 nm) excilamps were used in a photoreactor. Phototransformation was studied for compounds in the presence of PPMs modified with TiO2 particles. The results indicated that the toxicants concentration was reduced by two orders of magnitude in the presence of PPMs. This reduction was due to effective adsorption of naphthalene and anthracene from water onto the surface of the PPMs. Exposure to the toxicant–water–PPM system to UV light led to the formation of fluorescent photoproducts.
Anatomic characterization of the femoral nutrient artery: Application to fracture and surgery of the femur
Authors: Kawasaki Yuto , Kinose Shota , Kato Kota , Sakai Tatsuo , Ichimura Koichiro
Published: April 2019

The localization of nutrient foramina and direction of nutrient canals have been studied. However, information about the origin and extraosseous course of nutrient arteries is lacking in some types of long tubular and irregular bones. Thus, we aimed to reexamine the origin and course of the femoral nutrient artery (FNA) through cadaveric dissection to clarify its anatomic characteristics. Sixty thighs were collected from 57 cadavers. To fix the cadavers and visualize the small arterial branches, 10% formalin was injected from the femoral artery, followed by an injection of acrylic ink. The arterial tree in the posterior part of the thigh was recorded by line drawings. The femur received single or double FNAs via the femoral nutrient foramina, which were on and along the linea aspera. In cases with single FNA (41 of the 60 thighs), it typically arose from the four parts of the profunda femoris system: profunda femoris artery between the origins of the third and fourth perforating arteries; second perforating artery; third perforating artery; and terminal branch. In cases with double FNAs (remaining 19 thighs), the superior FNA typically arose from the second perforating artery, and the inferior FNA arose from the terminal branch of the profunda femoris artery and popliteal system. FNAs are described as branches of the perforating arteries in Terminologia Anatomica and anatomy textbooks. However, we found that FNAs also frequently arose from the profunda femoris artery and popliteal system, in addition to the perforating arteries. Clin. Anat. 33:479–487, 2020. © 2019 Wiley Periodicals, Inc.
Benefits of respiratory navigation aided MRI in case of large abdominal tumors of canines: A case study
Authors: Vaskó Márta , Orsi Gergely , Perlaki Gábor , Jakab Csaba , Vajdovich Péter , Bogner Péter , Benczik Judit
Published: April 2019

Key Clinical Message

Magnetic resonance imaging using respiratory navigation technique can be the number one diagnostic method determining operability of large‐sized abdominal tumors of dogs. This technique eliminates motion artifacts and makes possible the visualization of the origin and extent of the tumor and of the possible abdominal metastases.
IL‐10–producing regulatory B cells in skin diseases
Authors: Suga Hiraku , Sato Shinichi
Published: April 2019

B cells are generally considered to regulate immune responses positively because they differentiate into plasma cells and produce antigen‐specific antibodies. However, specific B‐cell subsets have been reported to regulate immune responses negatively and have been termed regulatory B cells. Accumulating evidence has shown that regulatory B cells play an important role in a variety of inflammatory and autoimmune diseases. Among several regulatory B‐cell subsets, IL‐10–producing regulatory B cells are the most widely investigated. This review focused on the role of regulatory B cells in autoimmune and inflammatory skin diseases. The frequency of IL‐10–producing B cells in the peripheral blood from patients with systemic sclerosis was decreased compared to healthy controls. In addition, the function of regulatory B cells was impaired in patients with systemic sclerosis. As for systemic lupus erythematosus, the frequency of regulatory B cells was increased in the peripheral blood, while their regulatory function was impaired. In inflammatory skin diseases including psoriasis and atopic dermatitis, the number of IL‐10–producing B cells was decreased compared to healthy controls. Similarly, patients with cutaneous T‐cell lymphoma showed decreased number of IL‐10–producing B cells. Taken together, regulatory B cells would play important roles in suppressing the disease onset, whose dysfunction might lead to worsening the disease symptoms. Revealing the mechanisms of human regulatory B cells in skin diseases could lead to the development of novel therapies targeting regulatory B cells.
Sustainable compensation policies and its effect on environmental, social, and governance scores
Authors: Baraibar‐Diez Elisa , Odriozola María D. , Fernández Sánchez José Luis
Published: April 2019

The incorporation of sustainable compensation policies reflects the willingness of companies to manage the behavior of directors towards long‐term goals, responding to a large number of stakeholders with different demands. Analysis of compensation policies is biased to financial performance, so that the effectiveness of sustainable policies remains unexplored. This paper investigates whether having a sustainable compensation policy has a positive influence on environmental, social, and governance (ESG) and economic scores. These relationships are tested by estimating a fixed‐effects model for listed companies from Spain, France, Germany, and the United Kingdom in the period 2005–2015. According to the results, sustainable compensation policies affect ESG scores, but especially when firms have a corporate social responsibility committee acting as control mechanism and supporting the achievement of those objectives, triggering better nonfinancial performance. This paper contributes to literature by exploring the effect of sustainable incentives and expands the range and richness of results by including four different scores.
Characteristics and simulation of snow interception by the canopy of primary spruce‐fir Korean pine forests in the Xiaoxing'an Mountains of China
Authors: Xiao Yang , Li Xiaosong , Zhao Shuping , Song Guohua
Published: April 2019

Snow interception by the forest canopy is an important control on the forest hydrological cycle in the Xiaoxing'an Mountains within the northern temperate region of China. In this study, the effects of snowfall characteristics and stand structures on the snowfall redistribution of the canopies within primary spruce‐fir Korean pine forests are analyzed at the forest stand scale. Characteristics of snowfall, through‐canopy snowfall, and stand structure are continuously measured using positioning observations. A semiempirical theoretical model is used to conduct snow interception simulations in the Xiaoxing'an Mountain region. The results indicate that the snowfall, canopy density, slope gradient, and tree height have a significant effect on the through‐canopy snowfall. The interception efficiency gradually decreases with an increase in the amount of snowfall and is particularly sensitive to the snowfall and canopy density, although it shows no significant correlation with average diameter at breast height, tree height, basal area, canopy height, canopy width, leaf area, or slope gradient. Very similar results have been observed in Canada and Switzerland, suggesting the transferability of the results between North America, Western Europe, and China. However, although model results provide a satisfactory simulation of snow interception, further studies are required to optimize the model in this region.
Anti‐predator mechanisms in evolutionarily predator‐naïve vs. adapted fish larvae
Authors: Ros Albert , Dunst Julian , Gugele Sarah , Brinker Alexander
Published: April 2019

It is a fundamental feature of evolution that natural selection acts on individuals to adapt to predation pressure via the development of anti‐predator mechanisms. As such mechanisms are costly in terms of energy and time, species living in habitats where predators are rare or absent were expected to show reduced predator responses. Such a reduction was expected for larvae of the native whitefish (Coregonus wartmanni) in Upper Lake Constance, as these pass their initial stage in a historically predator‐free pelagic habitat and only start to encounter predators in a later ontogenetic stage during which they shift to littoral habitat. However, a recent invader of the pelagic waters of the lake, the three‐spined stickleback (Gasterosteus aculeatus), is implicated in a severe decline in whitefish recruitment through larval predation. The predator‐naivety effect and its consequences on predation were experimentally tested by comparing predator defenses of different age classes of whitefish with those of roach (Rutilus rutilus) and perch (Perca fluviatilis), two species whose larvae grow up in a predator‐holding habitat. As predator, the three‐spined stickleback (Gasterosteus aculeatus) was selected. Sticklebacks actively hunted all prey species but predation was high on whitefish only. The addition of zooplankton (Daphnia) as alternative prey for sticklebacks in the experimental setup did not reduce predation on the whitefish larvae, indicating a clear preference for whitefish in this invasive predator. The escape responses of roach and perch were found to be clearly more complex and diverse to those of the predator‐naïve whitefish larvae. Particularly striking was that whitefish often did not show any apparent behavioral response to the approaching predator. Only large whitefish larvae (Table 1: length = 40.8 ± 0.6 mm) appeared capable of escaping predation, and this was correlated with a change in complexity of predator escape responses. Thus, differences in predation pressure for the different larvae species were highly related to the observed interspecific differences in predator defenses, and with the ontogenetic intraspecific change in whitefish from poor and inefficient predator escape responses to complex and more efficient predator escape responses. The evolutionary consequences of stickleback as an invasive predator on whitefish larvae behavior are discussed.
When groups do not cure: Group esteem moderates the social cure effect
Authors: DeMarco Tina C. , Newheiser Anna‐Kaisa
Published: April 2019

Group membership enhances well‐being. In two preregistered studies, we tested the assumption that only positively viewed groups yield this “social cure” effect and explored the impact of membership in negatively viewed groups, proposing that the social cure effect is qualified by group esteem (the degree to which ingroups are valued and liked). In Study 1 (N = 396), we manipulated social identity gain (vs. loss) and measured group esteem, and found that gaining (vs. losing) a group membership more strongly increased psychological need satisfaction when group esteem was higher. In Study 2 (N = 494), we manipulated identity gain (vs. loss) and group esteem, and found that gaining (vs. losing) a high‐esteem group membership enhanced well‐being via increased need satisfaction, whereas gaining (vs. losing) a low‐esteem group membership undermined well‐being via decreased need satisfaction. Our results contribute to conceptual models of how group membership influences individuals and suggest that membership in low‐esteem groups can harm well‐being.
Political and media discourses about integrating refugees in the UK
Authors: Goodman Simon , Kirkwood Steve
Published: April 2019

This article addresses political and media discourses about integrating refugees in the UK in the context of the “refugee crisis”. A discursive psychological approach is presented as the best way to understand what talk about the concept is used to accomplish in these debates. A large corpus of political discussions (13 hours of debate featuring 146 politicians) and 960 newspaper articles from the UK were discourse analysed. The analysis identified five dilemmas about integration: Integration is positive and necessary, but challenging; Host communities are presented as welcoming, but there are limits to their capacity; Refugees are responsible for integration, but host communities need to provide support; Good refugees integrate, bad ones don't; Refugees are vulnerable and are skilled. All are used to warrant the inclusion or exclusion of refugees. The responsibility of western nations to support refugees is therefore contingent on the refugees behaving in specific ways.
Experimental and computational analysis of the collector geometry of a solar chimney
Authors: Ayadi Ahmed , Driss Zied , Abid Mohamed Salah
Published: April 2019

The solar chimney power plants (SCPP) are thermodynamic devices that transform the heat produced by the solar radiation into electricity. A SCPP make significant contributions to the energy generating in countries where sunlight is available. The optimization of the solar setups is essential to enhance their economic profitability. In this article, a numerical method is investigated by the use of the commercial CFD code Ansys Fluent to analyze the airflow within the solar chimney. Different considered cases have been studied. Indeed, a new design of the SCPP is presented and compared with a conventional solar chimney power plant (CSCPP). The proposed design is characterized by a convergent collector output. For each case, the local flow characteristics were presented and discussed. This technical solution favorite the generated power of CSCPP. This article is identified important to increase the generated power for an existing SCPP.
Biogas production from most agricultural organic wastes by anaerobic digestion in Taiwan
Authors: Lo Fang‐Chen , Lin Kae‐Long , Pai Tzu‐Yi , Yang Wen‐Goang , Tzeng Yew‐Min , Chiu Hsun‐Ying , Lo Sheng‐Wen , Hsiao Kuo‐Chu , Banks Charles J. , Lo Huang‐Mu
Published: April 2019

Agricultural organic wastes (AOW) have the potential to provide bioenergy particularly found in biogas by anaerobic digestion (AD). In this study, the biogas production (BP) of AOW was obtained by batch AD with anaerobic digesters (500 mL) at 35°C incubator. The results showed that BP values in terms of volatile solids (VS) from rice husk, rice straw, flower residues, fruit and vegetable residues, wasted oyster shell residue (WOSR), fishery residues, livestock and poultry manures, livestock and poultry slaughter wastes (LPSW), and eight equally mixed wastes (EEMW) were 84.03, 193.36, 153.32, 76.27, 150.48, 63.26, 169.63, 615.74, and 172.83 mL/g VS, respectively. LPSW showed the highest μm of 16.99 mL/g VS‐d, the highest BP of 615.74 mL/g VS and the highest bioconversion efficiency of 65.98% compared to the other organic wastes. BP from the most AOW in Taiwan by AD was estimated to be 768,567,753 (743,522,223, excluding WOSR) m3/year. The annual BP of 768,567,753 m3/year of the eight total major AOW by AD was lower (∼20.11%) than 961,989,781 m3/year of the EEMW by anaerobic co‐digestion. Result also showed that modified Gompertz equation was suitable to describe BP accumulation and BP rate.
Effect of internal hydrocarbon reforming during coupled operation of a biomass gasifier with hot gas cleaning and SOFC stacks
Authors: Fischer Felix , Hauser Michael , Hauck Maximilian , Herrmann Stephan , Fendt Sebastian , Jeong Hyeondeok , Lenser Christian , Menzler Norbert H. , Spliethoff Hartmut
Published: April 2019

In the context of energy transition and climate change, a combination of highly efficient modern solid oxide fuel cells (SOFC) and thermo‐chemical conversion of biogenic residues could complement other intermittent renewable sources such as wind and solar. In order to reduce required gas cleaning efforts and to increase the process efficiency, the influence of hydrocarbons on SOFC performance is experimentally investigated in this study. For the first time, the operation of Ni/YSZ anode‐supported cells in Jülich F10 stacks is performed with pre‐reformed and with bio‐syngas containing full hydrocarbon content at realistic current densities. Sulfur and other impurities were removed in both cases. No degradation could be observed within normal operation on clean gas. With the tar reformer bypassed, the pressure drop over the stack increased due to severe carbon deposition on the anode substrate and the nickel current collector mesh inside the SOFC stack, so that operation had to be terminated after five hours. This behavior is different from single‐cell tests, where electrochemical degradation is the limiting factor. The results show that improvements are not only necessary for cell materials and that future research must also consider other stack components.
Experimental and numerical investigations on pressure pulsation in a pump mode operation of a pump as turbine
Authors: Zhang Jinfeng , Appiah Desmond , Zhang Fan , Yuan Shouqi , Gu Yandong , Asomani Stephen N.
Published: April 2019

Hydropower has been the leading renewable source and cheapest ways to generate electrical energy in the world. In recent years, there has been a major upsurge in the hydropower development because of the use of pump as turbine (PAT). However, the operational reliability of a PAT is greatly affected by the unsteady flow fields; therefore, it is important to examine the unsteady flow behavior which can be used as a reference to reduce the noise, vibration, and cavitation performance for centrifugal pumps working as turbines. Thus, the objective of this study was to evaluate the unsteady flow fields by analyzing the distribution of the pressure pulsations using both numerical and experimental measurements in a PAT operating in pump mode. Firstly, the three‐dimensional (3D) unsteady flow equations were solved using SST k‐ω turbulence model during the numerical calculations. Secondly, the numerical results of the hydraulic pump performance were validated by the experimental measurements for numerical accuracy. Lastly, pressure transducers are positioned at certain monitoring points to measure the pressure in the PAT investigated. The numerical and experimental results show that the main frequency of the pressure pulsation is equal to the blade frequency, and as it deviates from the design operating condition, the magnitude of pressure pulsation intensifies. Furthermore, the impeller eye marked the lowest pressure coefficients especially at the design condition and makes it highly susceptible to cavitation. High pressure coefficients were obviously seen at the pressure side on the blade surface closer to the trailing edge at all studied operating conditions. Meanwhile, the rotor‐stator interaction generated the highest pressure pulsation distribution at the volute tongue. Thus, modification of the volute tongue is an optimal approach of reducing the pressure pulsation intensity in the volute and pump as a whole.
Forecasting air pollution PM2.5 in Beijing using weather data and multiple kernel learning
Authors: Xu Xiang
Published: April 2019

PM2.5 mass concentration prediction is an important research issue because of the increasing impact of air pollution on the urban environment. In this paper, a PM2.5 forecasting framework incorporating meteorological factors based on multiple kernel learning (MKL) is proposed to forecast the near future PM2.5. In addition, we develop a novel two‐step algorithm for solving the primal MKL problem. Compared with most existing MKL 2‐step algorithms, the proposed algorithm does not require the optimal step size for updating kernel combination coefficients by linear search. To demonstrate the performance of the proposed forecasting framework, its performance is compared to single kernel‐based support vector regression (SVR). Data sets of an inland city Beijing acquired from UCI are used to train and validate both of two methods. Experiments show that our proposed method outperforms the SVR.
Successive grinding and sieving as a new tool to fractionate polyphenols and antioxidants of plants powders: Application to Boscia senegalensis seeds, Dichrostachys glomerata fruits, and Hibiscus sabdariffa calyx powders
Authors: Deli Markusse , Ndjantou Elie Baudelaire , Ngatchic Metsagang Josiane Thérèse , Petit Jeremy , Njintang Yanou Nicolas , Scher Joël
Published: April 2019

The present investigation aimed at evaluating the effect of powder fractionation based on particle size on the chemical composition in macronutrients, polyphenol contents, and antioxidant properties of powders of Boscia senegalensis seeds, Dichrostachys glomerata fruits, and Hibiscus sabdariffa calyces. Significant differences (p < 0.05) among granulometric classes of each plant were observed for the chemical composition in macronutrients. A decrease in particle size of plant powders was associated with an increase in ash, protein, and fat contents, while carbohydrate content was lowered. The following Granulometric classes, [0–180 µm] for Boscia senegalensis, [180–212 µm] for Dichrostachys glomerata, and [212–315 µm] for Hibiscus sabdariffa, respectively, were found to maximize total phenolic content and antioxidant activity. These results confirm that the grinding and controlled differential screening technology is an approach may serve as a useful guide to obtain optimum polyphenol extraction and enhance antioxidant activity of plant products.
Effect of whey protein on blood pressure in pre‐ and mildly hypertensive adults: A randomized controlled study
Authors: Yang Jing , Wang Hai‐Peng , Tong Xing , Li Zeng‐Ning , Xu Jia‐Ying , Zhou Li , Zhou Bing‐Yuan , Qin Li‐Qiang
Published: April 2019

In China, the frequency of mild hypertension cases remains prevalently high. Meanwhile, diets containing functional ingredients that control blood pressure have received considerable attention. In this randomized, controlled intervention study, 65 participants were randomly assigned to consume 30 g of whey protein or maltodextrin daily for 12 weeks. Blood pressure, body composition, biochemical analysis in plasma, and flow‐mediated dilation (FMD), an index for evaluating endothelial function, were measured. Finally, 54 participants (27 participants in each group) completed the study. At the end of the intervention, the average systolic blood pressure (SBP) was 129.5 ± 7.7 mmHg in the control group and 128.2 ± 6.9 mmHg in the whey protein group (p = 0.052). In the overweight and obese participants, the SBP was significantly lower in the whey protein group than in the control group (126.5 ± 6.9 mmHg vs. 128.8 ± 7.4 mmHg, p = 0.033), and body fat, fat percentage, and waist circumference significantly decreased in the whey protein group (p = 0.010, 0.016, 0.019, respectively). No difference was observed between the control and whey protein groups with regard to the changes in plasma lipids, inflammatory cytokines, antioxidative indexes, endothelium‐1, nitric oxide, angiotensin II, and angiotensin‐converting enzyme. The increase in FMD was significantly higher in the whey protein group than in the control group (5.2% vs. 0.3%, p = 0.040). In conclusion, whey protein significantly decreased SBP in pre‐ and mildly hypertensive adults, who are also overweight and obese. Whey protein also improved endothelial function. The lowering effect of blood pressure was probably related to body fat loss in these participants.
Using an inverse modelling approach with equifinality control to investigate the dominant controls on snowmelt nutrient export
Authors: Costa Diogo , Pomeroy John , Baulch Helen , Elliott Jane , Wheater Howard
Published: April 2019

There is great interest in modelling the export of nitrogen (N) and phosphorus (P) from agricultural fields because of ongoing challenges of eutrophication. However, the use of existing hydrochemistry models can be problematic in cold regions because models frequently employ incomplete or conceptually incorrect representations of the dominant cold regions hydrological processes and are overparameterized, often with insufficient data for validation. Here, a process‐based N model, WINTRA, which is coupled to a physically based cold regions hydrological model, was expanded to simulate P and account for overwinter soil nutrient biochemical cycling. An inverse modelling approach, using this model with consideration of parameter equifinality, was applied to an intensively monitored agricultural basin in Manitoba, Canada, to help identify the main climate, soil, and anthropogenic controls on nutrient export. Consistent with observations, the model results suggest that snow water equivalent, melt rate, snow cover depletion rate, and contributing area for run‐off generation determine the opportunity time and surface area for run‐off–soil interaction. These physical controls have not been addressed in existing models. Results also show that the time lag between the start of snowmelt and the arrival of peak nutrient concentration in run‐off increased with decreasing antecedent soil moisture content, highlighting potential implications of frozen soils on run‐off processes and hydrochemistry. The simulations showed TDP concentration peaks generally arriving earlier than NO3 but also decreasing faster afterwards, which suggests a significant contribution of plant residue Total dissolved Phosphorus (TDP) to early snowmelt run‐off. Antecedent fall tillage and fertilizer application increased TDP concentrations in spring snowmelt run‐off but did not consistently affect NO3 run‐off. In this case, the antecedent soil moisture content seemed to have had a dominant effect on overwinter soil N biogeochemical processes such as mineralization, which are often ignored in models. This work demonstrates both the need for better representation of cold regions processes in hydrochemical models and the model improvements that are possible if these are included.
CARD9 prevents lung cancer development by suppressing the expansion of myeloid‐derived suppressor cells and IDO production
Authors: Qu Junxing , Liu Ling , Xu Qianyun , Ren Jing , Xu Zhen , Dou Huan , Shen Sunan , Hou Yayi , Mou Yongbin , Wang Tingting
Published: April 2019

Caspase recruitment domain‐containing protein 9 (CARD9) is an adaptor protein and highly expressed in myeloid cells. Our previous study demonstrates a critical protective effect of CARD9 in the development of colitis‐associated colon cancer. Nevertheless, the effect of CARD9 in lung cancer remains unclear. Here, using a mouse Lewis lung cancer model, we found the tumor burden of CARD9−/− mice was much heavier than that in wild‐type (WT) mice. More myeloid‐derived suppressor cells (MDSCs) were accumulated and less cytotoxicity T lymphocyte was found in tumor tissues of CARD9−/− mice, compared to WT mice. Depleting MDSCs using anti‐Gr1 antibody can significantly decrease tumor burden in CARD9−/− mice. Furthermore, the noncanonical nuclear factor‐kappaB (NF‐κB) pathway was activated in CARD9−/− mice‐derived MDSCs. Deficiency of CARD9 enhanced expression of indoleamine 2,3‐dioxygenase (IDO) in MDSCs via noncanonical NF‐κB pathway. Moreover, correlations between CARD9 expressions and MDSCs relative genes (IDO, iNOS‐2 and arginase 1 [ARG‐1]) were further confirmed in tumor tissues from lung cancer patients. Taken together, we showed a CARD9‐NF‐κB‐IDO pathway in MDSCs which can inhibit the suppressive function of MDSCs and prevent lung cancer development.
Perfluorinated alkylated substances serum concentration and breast cancer risk: Evidence from a nested case‐control study in the French E3N cohort
Authors: Mancini Francesca Romana , Cano‐Sancho German , Gambaretti Juliette , Marchand Philippe , Boutron‐Ruault Marie‐Christine , Severi Gianluca , Arveux Patrick , Antignac Jean‐Philippe , Kvaskoff Marina
Published: April 2019

Endocrine‐disrupting chemicals are proposed to increase breast cancer (BC) incidence. Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA), two perfluorinated alkylated substances (PFASs), are suspected to be ubiquitously present in the blood of human population worldwide. We investigated the associations between serum concentrations of these substances and BC risk. Etude Epidémiologique auprès de femmes de l'Education Nationale is a cohort of 98,995 French women born in 1925–1950 and followed up since 1990. We sampled 194 BC cases and 194 controls from women with available blood samples. Serum concentrations of PFASs were measured by liquid chromatography coupled to tandem mass spectrometry (LC–MS/MS). Adjusted conditional logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). All statistical tests were two sided. While PFASs concentrations were not associated with BC risk overall, we found positively linear associations between PFOS concentrations and the risk of ER+ (3rd quartile: OR = 2.22 [CI = 1.05–4.69]; 4th quartile: OR = 2.33 [CI = 1.11–4.90]); Ptrend = 0.04) and PR+ tumors (3rd quartile: OR = 2.47 [CI = 1.07–5.65]; 4th quartile: OR = 2.76 [CI = 1.21–6.30]; Ptrend = 0.02). When considering receptor‐negative tumors, only the 2nd quartile of PFOS was associated with risk (ER−: OR = 15.40 [CI = 1.84–129.19]; PR−: OR = 3.47 [CI = 1.29–9.15]). While there was no association between PFOA and receptor‐positive BC risk, the 2nd quartile of PFOA was positively associated with the risk of receptor‐negative tumors (ER−: OR = 7.73 [CI = 1.46–41.08]; PR−: OR = 3.44 [CI = 1.30–9.10]). PFAS circulating levels were differentially associated with BC risk. While PFOS concentration was linearly associated with receptor‐positive tumors, only low concentrations of PFOS and PFOA were associated with receptor‐negative tumors. Our findings highlight the importance of considering exposure to PFASs as a potential risk factor for BC.
Fabrication and characterization of pectin‐based three‐dimensional porous scaffolds suitable for treatment of peritoneal adhesions
Authors: Kulikouskaya Viktoryia , Kraskouski Aliaksandr , Hileuskaya Kseniya , Zhura Alexandr , Tratsyak Stanislau , Agabekov Vladimir
Published: April 2019

Formation of peritoneal adhesions is common complication after abdominal and pelvic surgery. They bear a significant health problem with an influence to quality of life and health care expenses. Promising approach for their prevention is using of biodegradable barrier films for physical separation of peritoneal surfaces. In the present study, highly porous pectin‐based three‐dimensional (3D) scaffolds were obtained by freeze‐drying technique. Physico‐chemical properties of the formed materials, including their morphology, porosity, density, and stability, have been studied. The evaluation of their biocompatibility, biodegradation, and potential antiadhesion effect was studied by in vivo experiment. To reinforce the scaffolds structure and improve their stability in physiological solutions, pectin chains were cross‐linked with divalent cations. We determined optimal cross‐linking conditions, which allow obtaining scaffolds with desired biodegradation rate. These cross‐linked scaffolds fully dissolved within 8 days in the peritoneal cavity with low presence of complications and some antiadhesive effect. It has also been determined that mesenchymal stem cells from adipose tissue could effectively adhere to the scaffolds with preservation of their viability. Our results show that obtained materials can be suggested as mechanical scaffold for delivery of the stem cells culture to peritoneal surfaces as a part of complex antiadhesive barrier system.
Eriodictyol inhibits survival and inflammatory responses and promotes apoptosis in rheumatoid arthritis fibroblast‐like synoviocytes through AKT/FOXO1 signaling
Authors: Liu YingChun , Yan XiaoNing
Published: April 2019

2‐(3,4‐Dihydroxyphenyl)‐5,7‐dihydroxy‐2,3‐dihydrochromen‐4‐one (eriodictyol), a flavonoid compound, was proved to possess anti‐inflammatory, antioxidative, and antiarthritis activities. However, the effects of eriodictyol on the rheumatoid proliferation, apoptosis, and inflammatory response of arthritis fibroblast‐like synoviocytes (RA‐FLS) remain unclear. Thus, the objective of this study was to examine the effects of eriodictyol on RA‐FLS survival, apoptosis, and inflammatory response, and further explore the potential underlying mechanisms. Our results showed that eriodictyol inhibited the survival of RA‐FLSs and promoted its apoptosis. Eriodictyol significantly reduced RA‐FLS secretion of tumor necrosis factor α, interleukin 6 (IL‐6), IL‐8, and IL‐1β. Furthermore, eriodictyol prevented the activation of the protein kinase B (AKT) pathway and increased the expression of forkhead box O1 (FOXO1) in RA‐FLS. FOXO1 silence reversed the effects of eriodictyol on RA‐FLS survival, apoptosis, and inflammation. In conclusion, these findings indicated that eriodictyol inhibits the cell survival and inflammatory response in RA‐FLS, and the AKT/FOXO1 signaling pathway is involved in the effect of eriodictyol on the RA‐FLS. Thus, eriodictyol might be a potential therapeutic agent for the treatment of rheumatoid arthritis.
The expression of long non coding RNA genes is associated with expression with polymorphisms of HULC rs7763881 and MALAT1 rs619586 in hepatocellular carcinoma and HBV Egyptian patients
Authors: Motawi Tarek M.K. , El‐Maraghy Shohda A. , Sabry Dina , Mehana Noha A.
Published: April 2019

Long noncoding RNAs (lncRNAs), highly upregulated liver cancer (HULC), metastasis‐associated lung adenocarcinoma transcript 1 (MALAT1), lncRNA‐AF085935, and lncRNA‐uc003wbd have been implicated in hepatocellular carcinoma (HCC). Single‐nucleotide polymorphism (SNP) in HULC and MALAT1 are associated with HCC susceptibility. However, association between these SNPs and lncRNA‐AF085935 and lncRNA‐uc003wbd expression and their potential clinical value in differentiating HCC from both hepatitis B virus (HBV)‐infected Egyptian patients and the healthy specimens have not been explored yet. In the present study, SNPs rs7763881 in HULC and rs619586 in MALAT1 were genotyped in 70 HBV‐positive HCC, 70 HBV patients, and 70 healthy controls in Egyptian population and the level of serum lncRNA‐AF085935 and lncRNA‐uc003wbd of all the subjects was assayed by quantitative real‐time polymerase chain reaction. HULC rs7763881 AC/CC genotype was significantly associated with decreased HCC risk. Similarly, AG/GG of MALAT1 rs619586 was associated with decreased HCC risk with a borderline significance. Serum lncRNA‐AF085935 and lncRNA‐uc003wbd levels were upregulated in HBV‐positive HCC and HBV patients vs controls and discriminated these groups by receiver operating characteristic analysis. Patients carrying AC/CC genotype of rs7763881 and AG/GG of rs619586 had lower serum lncRNA‐AF085935 and lncRNA‐uc003wbd levels compared with AA genotype. In conclusion, genetic variants of lncRNA HULC and lncRNA MALAT1 are associated with the decreased susceptibility to HCC in HBV‐persistent carriers and are correlated with serum lncRNA‐AF085935 and lncRNAuc003wbd levels, two potential noninvasive diagnostic biomarkers for HCC.
Low‐intensity pulsed ultrasound promotes bone morphogenic protein 9‐induced osteogenesis and suppresses inhibitory effects of inflammatory cytokines on cellular responses via Rho‐associated kinase 1 in human periodontal ligament fibroblasts
Authors: Kusuyama Joji , Nakamura Toshiaki , Ohnishi Tomokazu , Albertson Brent G. , Ebe Yukari , Eiraku Nahoko , Noguchi Kazuyuki , Matsuguchi Tetsuya
Published: April 2019

Periodontal ligament fibroblasts (PDLFs) have osteogenic capacity, producing bone matrix proteins. Application of bone morphogenic proteins (BMPs) to PDLFs is a promising approach for periodontal regeneration. However, in chronic bone metabolic disorders, such as periodontitis, proper control of accompanying inflammation is essential for optimizing the effects of BMPs on PDLFs. We have previously shown that low‐intensity pulsed ultrasound (LIPUS), a medical technology that induces mechanical stress using sound waves, significantly promotes osteogenesis in mesenchymal stem cells. Here, we demonstrate that LIPUS promotes the BMP9‐induced osteogenic differentiation of PDLFs. In contrast, BMP2‐induced osteogenic differentiation was not altered by LIPUS, probably due to the LIPUS‐induced secretion of Noggin, a BMP2 antagonist, from PDLFs. To examine if LIPUS affects inflammatory responses of PDLFs to lipopolysaccharide (LPS) derived from Porphyromonas gingivalis (LPS‐PG), we also simultaneously treated PDLFs with LIPUS and LPS‐PG. Treatment with LIPUS significantly inhibited the phosphorylation of ERKs, TANK‐binding kinase 1, and interferon regulatory factor 3 in LPS‐PG‐stimulated PDLFs, in addition to inhibiting the degradation of IκB. Furthermore, LIPUS treatment reduced messenger RNA (mRNA) expression of interleukin‐1alpha (IL‐1alpha), IL‐1beta, IL‐6, IL‐8, C‐C motif chemokine ligand 2, C‐X‐C motif chemokine ligand 1 (CXCL1), CXCL10 and receptor activator of nuclear factor kappa‐B ligand, and also diminished IL‐1ß and tumor necrosis factor a (TNFa)‐induced inflammatory reactions. Phosphorylation of Rho‐associated kinase 1 (ROCK1) was induced by LIPUS, while ROCK1‐specific inhibitor prevented the promotive effects of LIPUS on p38 phosphorylation, mRNA expression of CXCL1 and Noggin, and osteogenesis. The suppressive effects of LIPUS on LPS‐PG‐stimulated inflammatory reactions were also prevented by ROCK1 inhibition. Moreover, LIPUS treatment blocked inhibitory effects of LPS‐PG and IL‐1ß on osteogenesis. These results indicate that LIPUS suppresses inflammatory effects of LPS‐PG, IL‐1ß, and TNFa and also promotes BMP9‐induced osteogenesis through ROCK1 in PDLFs.
Retracted: Sapylin inhibits lung cancer cell proliferation and promotes apoptosis by attenuating PI3K/AKT signaling
Authors: Zhang Lin , Liu Benhong
Published: April 2019

Sapylin (OK‐432) revealed biological properties in cancers. In this study, the effect of sapylin on lung cancer cell A549 was investigated. A549 cell lines were treated with sapylin (0.1, 0.5, and 1 KE/mL) for different time intervals. A549 cell proliferation and apoptosis was determined using 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl‐2H‐tetrazolium bromide/Ki67 assay and flow cytometry, respectively. Western blot was used to determine the expressions of proteins involved in proliferation, apoptosis, and phosphoinositide 3‐kinase/serine/threonine kinase (PI3K/AKT), Wnt3a/β‐catenin signaling pathway. Level of intracellular reactive oxygen species (ROS) was insured by using the ROS kit. Sapylin inhibited A549 cell viability and the expressions of proliferation‐related proteins (cyclin E1 and D1) in dose‐ and time‐dependent manners. Sapylin promoted apoptosis in a dose‐ and time‐dependent manners. Sapylin also promoted the expressions of apoptotic proteins (cleaved caspase‐3 and 8) in dose‐ and time‐dependent manners. Furthermore, sapylin increased the intracellular concentration of ROS in a dose‐dependent manner. Besides, the high expression of ROS level might induce inhibition of cell viability and increase cell apoptosis. The mechanistic study revealed that sapylin inactivated the PI3K/AKT and Wnt3a/β‐catenin signaling pathways. Our findings suggest that sapylin inhibits proliferation and promotes apoptosis in lung cancer cells, thus providing a new theoretical basis for the treatment of lung cancer.