bluuebunny/crossref_metadata_2025 huggingface dataset:
Adesão ao tratamento nas demências: como superar esse desafio?
Authors: Gouveia Paulino Fernanda , Ligero Saito Ana Carolina , Ferreira de Lira Pamela
Published: March 2022

Introdução: Como condição evolutiva, a adesão ao tratamento das demências envolve desafios que requerem múltiplas aptidões: flexibilidade e capacidade de adaptação, compreensão de necessidades e mudanças além de estabilidade emocional para enfrentamento. Tratamentos envolvem intervenções farmacológicas e não farmacológicas e educação continuada qualificada. A adesão a tratamento é multifatorial e tende a ser baixa e descontinuada. Objetivo: Criar material informativo com foco em favorecer adesão a tratamento das demências para diferentes públicos. Método: Foi realizada pesquisa aplicada, de abordagem qualitativa com grupos de discussão sobre estratégias para adesão com diferentes públicos (idosos, familiares cuidadores, cuidadores de idosos e profissionais de saúde). A revisão bibliográfica abordou materiais informativos (folhetos, sites, vídeos e cursos de formação) sobre tratamentos em demência. Resultados: A revisão apontou baixo incentivo a adesão ao tratamento com tendência a superficialidade e foco nos aspectos degenerativos com mensagens pouco motivadoras para tratamento continuado. Foi criado material informativo para atender demandas de diferentes públicos envolvidos no cuidado de pessoas com demência em dois formatos: (1) cartilha com descrição de tratamentos e benefícios com dicas específicas de como cada público pode contribuir para adesão ao tratamento e (2) vídeos documentais com relatos de familiares experientes para sensibilizar e demonstrar alternativas de enfrentamento.Material envolve: dicas, orientações e inspirações a partir de conteúdo, estratégias e histórias de enfrentamento e superação. Discussão: Informações que favoreçam redução de estigma e que aproximem do cuidado precisam envolver diferentesatoresalém de quebrarestereótipos. Conteú dos falsos ou milagrosos bem como que mostrem apenas sofrimento afastam das estratégias de cuidado e favorecem descontinuidade em quadro que requer flexibilidade e tarefa de longo prazo. Material informativo motivador que aponta para soluções de alternativas de cuidado com depoimentos inspiradores que aproximam de realidades possíveis foram apontadas como estratégias mais apropriadas para adesão a tratamentos e cuidados prolongados adequados.
Aplicación de "serious games" en el tratamiento de la demencia: revisión sistemática
Authors: Rodríguez Domínguez Trinidad , Gómez Banda Rubén , Ortega Morán Juan Francisco , Santurino Muñoz Marta , Pagador Blas
Published: March 2022

La demencia es una enfermedad de carácter crónico y curso degenerativo que afecta de un amplio modo a la función cognitiva (capacidad de procesar el pensamiento). Debido al aumento de la esperanza de vida y a los avances técnicos en el campo de la medicina, nos encontramos ante un escenario en el que se estima que en el año 2030 el número de personas con demencia alcance los 82 millones, llegando a 152 millones en 2050 (1). Para su tratamiento se han utilizado terapias farmacológicas de éxito cuestionable. En los últimos años, los “serious games” se han abierto paso como una alternativa en el tratamiento de la demencia. Existe una abundante y diversa investigación en relación a este tema. Sin embargo, se hace necesaria una mayor homogeneidad en cuanto al diseño de las intervenciones se refiere, así como de las variables utilizadas, que facilite el futuro de la investigación en dicho campo. Por otro lado, queda patente la necesidad de la presencia de profesionales como los Terapeutas Ocupacionales en dichas investigaciones, los cuales pueden aportar una visión más amplia del impacto de la enfermedad en las distintas áreas ocupacionales, haciendo especial hincapié en el área del juego (2), el cual está recogido en su marco de trabajo para la práctica profesional. En esta revisión sistemática, analizamos artículos que comprenden el uso de “serious games” en el tratamiento de la demencia extrayendo los pros y contras, y sugiriendo pequeños cambios que pueden mejorar la investigación en dicho campo.
Los antidepresivos en la neurología: una visión más allá de la depresión
Authors: Benítez Sánchez Elena Inmaculada , Sánchez Casado J. Inmaculada , Marcos Toledano Mª del Mar , Sánchez Herrera Susana
Published: March 2022

Los antidepresivos son fármacos muy comunmente utilizados en el área de la Neurología, el problema es que su uso se ve limitado en muchas ocasiones por los profesionales al tratamiento específico de la depresión. Con este análisis del estado de la cuestión, se pretende valorar el uso de los antidepresivos más allá de lo común, y proveer de una visión más holística con respecto a su uso en otras patologías. Para ello se va a analizar algunas de las enfermedades más prevalentes en la neurología como son el deterioro cognitivo, la enfermedad de Parkinson, el Alzheimer, la Esclerosis Múltiple, el Post-Ictus, la Cefalea Tensional o la Migraña. Lo interesante de nuestra aportación es visibilizar que los problemas neurológicos pueden ser tratados y mejorar su curso, evolución y pronóstico con el tratamiento antidepresivo; y que éste se extiende más allá de lo que sería un “simple tratamiento de la depresión per se”. En ese sentido la calidad de vida de los pacientes, su autodeterminación y participación social se ven sensiblemente mejoradas al ajustar las interacciones de los fármacos de última generación.
Infancia em mudança rotinas de vida de um rapaz de 10 anos de Alcaria (fundão)
Authors: Faustino António , Ascensão Daniel , Furtado Daniela , Fernandes Helena , Costa Inês , Freire Rafael
Published: March 2022

A investigação teve como objetivo caraterizar a rotina diária de um rapaz de 10 anos. O estudo baseou-se na realização de entrevistas narrativas e semiestruturadas com registo audiovisual, elaboração de mapas diários de ocupação temporal, registos fotográficos, assim como na execução de mapas subjetivos da habitação, rua e outros locais que frequenta, entrevistas de inventário dos objetos pessoais da criança e documentação fotográfica. Efetuámos ainda o devido acompanhamento nas suas tarefas quotidianas, pelos locais que habitualmente frequenta, durante uma semana. Os dados obtidos foram categorizados em função das atividades realizadas pela criança, seguindo-se uma análise ao tempo dedicado a cada atividade e categoria, tendo em conta os dias da semana, atividades que implicam movimento ou não, as ações realizadas dentro e fora de casa. Através da sua análise pode-se verificar que a criança em estudo vive com os seus pais e irmão, numa vivenda localizada numa quinta. A criança frequenta diariamente o ATL e pratica futsal. Esta criança, no seu Mundo Vivido despende muito tempo (todos os dias da semana de manhã e à tarde) em instituições (escola e ATL). O restante é passado em casa e no espaço envolvente. No que respeita ao Mundo do Movimento, passa a maior parte do tempo no quarto a jogar Playstation e a ver televisão.
Estudo da consistência interna e análise fatorial exploratória da escala contínuo da saúde mental CCHS-MH em agricultores de Portugal
Authors: Balula Chaves Cláudia , Sequeira Carlos , Carvalho Duarte João , Nelas Paula , De Carvalho Coutinho Emília , Dionísio Rui Manuel
Published: March 2022

Os agricultores são um dos grupos ocupacionais com significativo risco de vulnerabilidade em termos de saúde mental, apresentando prevalência de morbidade psiquiátrica, em resultado dos efeitos dos fatores globais, nacionais, regionais, comunitários e locais. Estudar a consistência interna e análise fatorial exploratória da escala contínuo da saúde mental em agricultores e identificar que variáveis sociodemográficas dos agricultores que interferem na sua saúde mental. Estudo quantitativo, com corte transversal, descritivo analítico-correlacional. Os dados foram colhidos junto de 155 agricultores da região Norte e Centro de Portugal Continental, maioritariamente do género masculino (52,9%), com uma média de idades de 53,41 anos (±14,04 anos). O instrumento de recolha de dados contém um questionário de caracterização sociodemográfica e a Escala Contínuo de Saúde Mental – CCHS-MH 2012. As variáveis sociodemográficas com relevância estatística são o género e a constituição do agregado familiar. As mulheres e os agricultores com agregado familiar de 3 elementos revelam melhor saúde mental. Após a realização da análise fatorial confirmatória para uma população de agricultores e depois da análise livre, caíram dois itens (4 e 5) porque <0,44, mas após a rotação varimax estes dois foram agrupados ao fator 3, os itens eliminados aproximam-se da resposta (tendência de resposta) do fator 3. Os participantes dacontínuo da saúde mental apresentam índices mais elevados de bem-estar social e menos no bem-estar emocional, sugerindo-se uma política de literacia em saúde mental que abranja todo um conjunto de leis, programas, financiamentos, que estejam ao alcance de todos os agricultores.
Inclusão de crianças com NEE no ensino regular: análise numa perspetiva de trabalho colaborativo entre o docente de educação especial e o docente do ensino regular
Authors: Martins Simões Paulo M. Fátima , Sánchez Casado J. Inmaculada
Published: March 2022

Atualmente, a Educação, que se pretende inclusiva, debate-se com a necessidade de ampliar a atuação pedagógica, num modelo de trabalho que se ambiciona dinâmico,cooperativo ecolaborativo, num processo educativo que se quer de todos, para todos. Um crescente número de alunos identificados com necessidades educativas especiais recebem a sua educação, ou pelo menos parte dela, em salas de aula de educação regular fazendo com que haja uma necessidade cada vez maior que os docentes do ensino regular estejam preparados para irem ao encontro dos interesses e necessidades de todos os alunos, visando o seu sucesso educativo e social.
[RETRACTED] Holly Willoughby Keto UK v1
Authors: Willoughby Keto UK Holly
Published: March 2022

[RETRACTED]

Holly Willoughby Keto UK
DİYARBAKIR İLİ BİYOKÜTLE POTANSİYELİ VE ENERJİ ÜRETİMİ
Authors: YILDIRIM Ayşegül Mizgin , NACAR KOÇER Nilüfer
Published: March 2022

Artan dünya nüfusu, azalan kaynaklar, global ölçekte yaşanan çevre sorunları, fosil yakıtların sınırlı ve tükenmeye yakın oluşu enerjinin orta ve uzun vadede ulaşılabilirliğinin azalacağinı göstermektedir. 2015 yılında Birleşmiş Milletler Kalkınma Programı kapsamında kabul edilen Sürdürülebilir Kalkınma Amaçları (“SKA”) kapsamındaki 2030 yılına kadar ulaşılması hedeflenen 17 amaçtan biri “Erişilebilir ve Temiz Enerji” kaynaklarıdır. Temiz enerjiye adil ve eşitlikli erişim, sürdürülebilir kalkınma ve doğa için, yenilenebilir enerji kaynaklarına yönelim bir ihtiyaç ve zorunluluktur. Yenilenebilir enerji kaynakları arasında biyokütle enerjisi önemli bir erişilebilir ve temiz enerji olanağı sunmaktadır.

Bu çalışmadadünya genelinden Diyarbakır İli özeline olacak bir kapsamla olası biyoenerji potansiyelinin neden değerlendirilmesi gerektiğine değinilmiş, biyokütle, biyokütle kaynakları ve biyoenerji çevrim teknolojileri tanımlanmış ve Diyarbakır İli ve ilçelerine ait 2019 ve 2020 yıllarındaki hayvansal ve tarım kaynaklı ortalama kuru biyokütle miktarı ve ısıl değeri hesaplanarak yorumlanmıştır.
Reasons and Conditions for the Abuse of the Right in the Legal Process of Russia in the Light of the Costs of Implementing an Adversarial Principle
Authors: Matveeva E. S.
Published: March 2022

Effective counteraction to the abuse of the right in the legal process is impossible without understanding the causes and conditions of the forms of abuse of the right encountered in practice, which are the ways of its external expression. Consideration of the doctrine and judicial practice of civil, arbitration, administrative, criminal procedure through the prism of the adversarial principle, characteristic of all the types of legal process presented, contributed to the identification of general patterns that cause the abuse of procedural right. In the course of the study, the author examined the forms of abuse of the right (discretionary powers) associated with the implementation of evidentiary activities of the parties to the proceedings, excessive appeals against the actions of the parties, numerous filings of applications, motions, and challenges. The author concludes that the cause of this negative phenomenon is the desire of a person to satisfy his interests, aspirations, emotions in an illegal way. Conditions for the abuse of procedural law arising from the costs of the adversarial principle include a vulgar interpretation of the adversarial principle, a conflict of interests of the parties to the process, subjectivism of a law enforcement officer, his condoning attitude to the presence of abuse of the right. An opponent’s unintentional provocation can cause the abuse of the right in some situations.
Administrative and Legal Support for the Process of Democratization of Public-Service Relations in the Prosecution Authorities
Authors: Smirnov A. V.
Published: March 2022

The author of the paper makes an attempt to identify the problems of development of the institution of public service in the Russian Federation on the example of the prosecution service. The purpose of the paper is to study the features of service relations in the prosecutor’s office for their compliance with modern trends in the development of the state and society that determine the need for fundamentally new personal and professional characteristics of prosecutors. The paper highlights the imperfection of the current administrative and legal regulation of individual elements of service relations. Based on the results of the study, the author puts forward proposals for the introduction of qualitatively different approaches to the selection, training, retraining and employment of the personnel aimed at improving professional qualifications and competitiveness of staff members, their compliance with high moral and ethical requirements for this category of employees, ensuring openness and transparency of prosecution offices egencies and their employees. In particular, it is proposed to enshrine in law qualification requirements for all positions in the prosecutor’s office and for candidates applying for such positions, develop and implement a system of key performance indicators for the service and rating of candidates for the personnel reserve, a national database of applicants for managerial positions, intensify work on holding patriotic events, strengthen the status and significance of the procedure of taking the oath. In order to democratize public-service relations in the prosecutor’s office, the paper focuses on the need to revise a number of legislative provisions.
Issues of Application of Amended Provisions of the Tax Code of the Russian Federation concerning the Patent System of Taxation
Authors: Popkova Zh. G.
Published: March 2022

The paper examines changes in legislation on the patent system of taxation that have taken place since January 1, 2021, and that allow raising the question of constitutionality of this special taxation regime as a whole. The legislator has excluded restrictions for regional legislative bodies that establish the maximum amount of the potential income of an individual entrepreneur, and through it the amount of tax under the patent taxation system. Thus, the federal legislator actually got rid of the real restrictions on the powers of regional legislative bodies that regulate the patent taxation system. At the same time, the Constitutional Court of the Russian Federation since the 1990s repeatedly expressed legal positions, according to which the absence of such restrictions is unacceptable. The author makes suggestions on possible ways to solve the problem. It is possible that the Constitutional Court of the Russian Federation could recognize the exclusion of restrictions by the federal legislator as unconstitutional. However, taking into account the previous experience, it is possible that there will be no reaction on the part of the interested parties to the essentially unconstitutional changes introduced into the legislation.
Theoretical and Law Enforcement Aspects of Deprivation and Restriction of Parental Rights
Authors: Lekanova E. E.
Published: March 2022

The issues concerning delimitation of the grounds and conditions for the restriction and deprivation of parental rights are very relevant both at the doctrinal and practical levels. Difficulties in choosing a measure of family law protection are demonstrated by examples from judicial practice. The paper analyzes a law enforcement issue regarding the difficulty of identifying and taking into account a difficult life situation (a combination of difficult circumstances) in which a parent finds himself or herself. A difficult life situation excludes wrongful dangerous parental conduct. However, the courts cannot take it into account in the event of a claim for deprivation of parental rights, since the courts are not entitled to go beyond the stated requirements in this category of cases. The author comes to the conclusion that it is necessary to give the court the right to go beyond the claims initiated by the claimant to make a decision on the deprivation of parental rights, if a claim is filed to restrict parental rights and the court finds grounds for deprivation of parental rights. The court should also be empowered to make decisions in unasserted claims in the opposite situation, when the claimant demands to deprive the defendant of parental rights due to the danger of the child being in a parental environment, but the court has not found grounds for depriving of parental rights.
Some Issues of Differentiation of Personal and Non-Personal Data in the Law of the European Union
Authors: Krylova M. S.
Published: March 2022

The paper is devoted to the problems of differentiation of the categories «personal data» and «nonpersonal data» in the law of the European Union in the context of information and communication technologies development. The definitions of these concepts, their relationship and interrelation in the context of the application of the concept of dichotomous separation of information in EU law are considered. The criteria for distinguishing between personal and non-personal data are analyzed, based on the essential characteristics and relevance of the information being processed, as well as on the characteristics of the data subject and the possibility of his identification. The place of pseudonymized and anonymized data in the classification of information is indicated. An algorithm used in the EU for determining the category of data is formulated, which has a relativistic nature and is based on the assessment of the risk of identifying an individual in combination with the concept of «reasonable probability». An approach to the legal regulation in the European Union of processing mixed data sets, which are often encountered in practice and include both personal and non-personal data, is considered.
Improving the Mechanisms for Coordination and System Management in Interaction between Government Agencies and Educational Institutions of Higher Education in relation to Activities aimed at Attracting Foreign Citizens
Authors: Egorova M. A. , Grib V. V. , Minbaleev A. V.
Published: March 2022

The authors studied a number of projects and concepts aimed at increasing interest in the Russian education system among foreign students, as well as the functions of state structures involved in their implementation. Analyzing existing programs, the authors pay special attention to the activities of Rossotrudnichestvo. In conclusion, a number of measures are proposed aimed at developing the coordination of the work of state structures and educational institutions to attract foreign students. In the context of globalization and the active introduction of digital technologies in all spheres of society, the institution of cooperation between educational institutions of higher education and state authorities, specialized state organizations in the field of attracting foreign citizens to study at Russian universities also depends on the features of remote work and digitalization processes. The paper analyzes the main directions of the use of individual digital technologies in these respects. The main directions for increasing the presence of Russian educational organizations in the global Internet space and increasing the effectiveness of marketing digital strategies are considered.
Blister beetle bites: a case report
Authors: Olisova Olga Yu. , Teplyuk Natalia P. , Tavitova Alana R. , Shamilova Lyaman F.
Published: March 2022

Contacts with insects of the order coleoptera of the families Meloidae and Oedemeridae, in particular the bites of the abscess beetle, lead to acantholysis and the formation of intraepidermal blisters, as well as nonspecific skin damage. The family Meloidae (true abscess beetles) are distributed almost everywhere, with the exception of the territories of New Zealand, Antarctica and the Polynesian islands.
Insect species of the Meloidea family have a unique life cycle. Meloidae females lay eggs not only on coleoptera larvae, but also on any other insects, such as crickets, mantises, wasps, bees, on which their metamorphosis continues in the future. Populations of abscess beetles number a large number of individuals, which increases the risk of their meeting with humans. These species have a highly toxic colorless and odorless poison of non-protein nature ― cantharidin.
There is a rare clinical case of an abscess beetle bite. The debut of the disease occurred at the time of the patients trip to the island of Goa (India), where he noted insect bites with the appearance of the first blistering rashes and further progression of the skin process. The primary diagnosis was complicated by nonspecific changes detected during the pathomorphological examination of the skin, in the form of subacute dermatitis without classical manifestations of acantholysis with intradermal blisters due to delayed biopsy appointment. Against the background of ongoing treatment (prednisone; corrective therapy with potassium, magnesium, calcium, gastroprotectors; antibiotics; nonsteroidal anti-inflammatory and antimycotic drugs; combined topical glucocorticoids; a course of systemic autohemoozonotherapy) from the skin process, positive dynamics was noted in the form of relief of inflammatory phenomena, partial epithelization of wound defects.
Secondary infection of rashes, accompanied, as in this case, by abscessing, is often found with bites of various insect families: cases up to the development of necrotic fasciitis with a fatal outcome are described.
The described case is of clinical, scientific and epidemiological interest due to the isolated publications on this nosology and the complexity of diagnosis. Knowledge of the clinical picture of the disease will allow practitioners to develop tactics for managing patients with timely selection of effective therapy.
Current approaches to the treatment of atopic dermatitis: a review of the literature
Authors: Bakurov Evgenii V.
Published: March 2022

Atopic dermatitis (AtD) ― one of the most common inflammatory skin diseases often characterized by limited or short-time efficacy of traditional treatment options.
The PubMed and eLibrary databases were searched for full text articles and reviews about novel approaches to the treatment of this skin disorder published between 2015 and 2021.
This review aims to provide an overview of the recent pathogenetic pathways which are considered as main immunologic targets in the development of novel therapeutic strategies and discovering of future opportunities in the treatment of AtD. There are analysed and systematized novel data about systemic medications such as Dupilumab and a number of other monoclonal antibodies and JAK-inhibitors recently implemented in the practice and currently are clinical expertising in the different phases of trials of their efficacy and safety. Novel topical medications are considered separately including JAK-inhibitors, phosphodiesterase 4 inhibitor and aryl hydrocarbon receptor modulator. AtD is a complex disease characterized by different underlying molecular mechanisms/endotypes and phenotypes. This heterogeneity advocates against the traditional one-size-fits-all therapeutic approaches still used to manage AtD.
Therapies targeting different cytokine axes and other mechanisms involved in disease pathogenesis will expand our ability of control of AtD including his therapy-refractory cases. Recent research advancements about clinical and immunological diseases variability and different endotypes indicate that control of this disorder must be based on pathogenetic approaches and therefore on the concept of individualized therapy.
Inhibition of mTOR protects against skeletal muscle and kidney injury following hindlimb ischemia-reperfusion in rats by regulating MEK1/ERK1/2 activity
Authors: AKINCI UYSAL Çağla , TEMİZ REŞİTOĞLU Meryem , GÜDEN Demet Sinem , ŞENOL Sefika Pınar , VEZİR Özden , SUCU Nehir , TUNÇTAN Bahar , MALİK Kafait U. , FIRAT Seyhan
Published: March 2022

Purpose: We have previously demonstrated that activation of the mammalian target of rapamycin (mTOR)/inhibitory-κB-α/nuclear factor-κB p65 signaling pathway mediates organ injuries through increased oxidative/nitrosative stress and inflammatory response in rat models of hind limb ischemia/reperfusion (HL I/R). Following up our previous findings regarding I/R injury through mammalian target of rapamycin (mTOR), we aimed to focus on the possible interaction between mammalian target of rapamycin (mTOR and mitogen-activated protein kinase kinase (MEK)1/extracellular signal-regulated kinase (ERK) 1/2 pathway in hind limb ischemia/reperfusion (HL I/R) resulting in target and remote organ injuries in the present study.
Materials and Methods: Male Wistar rats were divided into four groups. HL I/R was induced by occluding with tourniquets of both hind limbs. Following 4 h, the tourniquets were removed following reperfusion for 4 h. After 4 h of reperfusion blood, kidney, and gastrocnemius muscle were collected.
Results: HL I/R caused an increase in phosphorylation and/or expression of rpS6, MEK1, ERK1/2, tumor necrosis factor-α, inducible nitric oxide synthase, gp91phox, p22phox, and nitrotyrosine as well as nitrite levels in gastrocnemius muscle, kidney, and/or serum. Additionally, nicotinamide adenine dinucleotide phosphate oxidase and myeloperoxidase levels were increased in the tissues of rats subjected to HL I/R. Rapamycin, the selective inhibitor of mTOR, abolished all the effects mentioned above caused by HL I/R in the rat’s muscle and kidney.
Conclusion: These data suggest that activation of the MEK1/ERK1/2 pathway contributes to mTOR-mediated HL I/R-induced target and remote organ injury.
Psychological symptoms and sexual satisfaction in polygamic and monogamic wives
Authors: YILMAZ Ertan
Published: March 2022

Purpose: This study aimed to investigate the sexual satisfaction and mental health indicators in polygamous and monogamous women in Turkey. The study included 108 female participants: 36 monogamous wives and 72 polygamous wives.

Materials and Methods: The participants were evaluated with the Symptom Check List (SCL-90-R) and Golombok-Rust Inventory of Sexual Satisfaction (GRISS).

Results: There were significant differences between the groups regarding the total GRISS score and Dissatisfaction, Sensuality, Vaginismus, and Anorgasmia subscale scores. In comparing the SCL-90 scores with ANOVA, the senior wife group had significantly higher scores in the Depression subscales. Monogamic wives had higher satisfaction from their sexual lives and had less frequent psychiatric symptoms than polygamic wives.

Conclusion: It is important to raise awareness about the polygamic family structure, draw attention to often neglected issues such as sexual health, and improve the health services provided to this group.
Evaluation of lipid levels and LDL-C/HDL-C ratio as possible risk markers of intracerebral hemorrhage
Authors: ADIGÜZEL Ahmet , ÇIPLAK Sibel , ÖZTÜRK Ünal
Published: March 2022

Purpose: The aim of this study is to analyze the utility of lipid parameters individually and the low-density lipoprotein cholesterol/high-density lipoprotein cholesterol (LDL-C/HDL-C) ratio as a possible risk marker for intracerebral hemorrhages (ICH).

Materials and Methods: This was a multicenter, retrospective case-control study that included 226 patients with ICH and 226 controls. Lipid parameters were evaluated after 12 h of fasting in patients whose ICH was confirmed by brain computed tomography, and no underlying vascular, traumatic, or metabolic cause could be found.

Results: The mean LDL-C levels and mean total cholesterol (TC) levels did not differ in in the patient and control groups. The mean HDL-C levels in the patient groups were significantly lower whereas triglyceride (TG) levels were significantly higher. In the patient and control groups, LDL-C/HDL-C ratio was 2.65±1.10 and 2.94±1.13 (p=0.006), TG/HDL-C ratio was 3.60±2.72 and 4.47±3.25 (p=0.002), and TC/HDL-C ratio was 4.37±1.49 and 4.83 ± 1.56 (p=0.002), respectively.

Conclusion: Increased TG and decreased HDL-C levels were found to be associated with ICHs. However LDL-C/HDL-C, TC/HDL-C, and TG/HDL-C ratios were low in the patient group. Therefore, we can conclude that these lipid ratios give clearer and more significant results in determining the risk of hemorrhage.
Pharmacoepidemiology of yellow trumpet flower
Authors: Borse Manali , Bagade Shubham , Bendale Atul , Borse Laxmikant , Jadhav Anil
Published: March 2022

Because synthetic pharmaceuticals may produce various side effects and unfavorable consequences, the use of natural plants in therapy is currently more common than synthetic goods. Tecoma stans is a plant found in most tropical countries. This plant belongs to the Bignoniaceae family and is already used in ancient medicine in various countries such as India and Pakistan. This plant has a large number of active chemical ingredients and has pharmacological effects. Many researchers have explored pharmacological screening, and ongoing research is being conducted in that plant. The goal of this study was to update the plant's research collections for pharmacological screening. The review focuses on several researches, such as pharmacognostical studies and in-vitro and in-vivo screening of numorous Tecoma stans components. The various parts of the plants were concluded to have various pharmacological actions such as anti-inflammatory, analgesic, anticancer cardioprotective effect, genotoxic, cytotoxicity, wound healing, antihyperglycemic, protect CNS, gastric ulcer healing, antiproliferative, antioxidant, anti-microbial, haemolytic activity, anti-lipoxygenase, and acetyl-cholinesterase inhibitory activities. This review was then used to guide future study on this plant. A member of the trumpet vine family, Tecoma stans, has been documented for a variety of pharmacological properties. The current research focuses on the neuropharmacological activities of several Tecoma stans extracts. The CNS depressive action was addressed first, followed by the analgesic activity, and then the impact of various extracts on Albino mice was examined.
Adverse events following immunization (AEFI) for Covid vaccines approved by WHO- A short review
Authors: Lingadurai Sutharson , Mariappan Gurusamy
Published: March 2022

The world was suffering and People are in great grief due to COVID 19 Pandemic 2020 and 2021 due loss of life, jobs and other related socio-economic issues and now it has been in subsiding mode due to the great weapon COVID vaccine. However omicron is now threatening due to high transmissibility compare to other variants of Corona virus. All of us aware corona Vaccines have been permitted by the regulatory authorities of different countries under emergency situation for restricted use. However by considering Risk-Benefit almost >18 age group most of the people have received the vaccine in few countries but yet to reach out all people in the world. The vaccine has reached the market with exemption category and without detailed exploration of all safety parameters. In the current situation it was learned that most of the corona vaccines are safe and Adverse Events Following Immunization (AEFI) associated with all other vaccines are reported except few serious adverse effects. Corona vaccines are in the verge for administration for all age groups. Hence our health care scientist in the globe needs to study and closely to monitor the Safety parameters of all approved vaccines. This short review highlighted the ADRs reported by WHO approved vaccines during clinical trials and in treatment Adverse Events Following Immunization (AEFI).
Analysis of MER with subthalamic nucleus stimulations with deep brain stimulation
Authors: Raju V Rama
Published: March 2022

Parkinson`s disease (PD) is a complex neurodegenerative brain disease with distinctive molecular, functional and structural features causing tremors, particularly in the old-age (>=60) and very rarely occur in adults and in children’s too due to the damage of the substantia nigra of central nervous system (CNS) and is differentiated by the convolution of cardinal motor symptoms (tremor, Bradykinesia/akinesia (slowness of movement, i.e., absence, delay in initiation), rigidity followed by the postural-instability. In addition these motor symptoms, cognitive motor and axial symptoms, such as cognitive impairment, cognitive dementia, hallucinations, shaking the whole body and changes in the speech like slurred speech, etc., and also affect the Parkinson`s malady due to the L-dopa (levodopa acts like a pre cursor to the dopamine, a panacea which reduces the symptoms but there are dyskinesia`s, i.e., side effects to the patients). By the clinical/prognostic diagnosis followed by the advantages of stimulations with the deep-brain-stimulators (DBS) in subthalamic-nucleus (i.e.,S.T.N, or s-nucleus) that have been established. But then, exactly in what way, by what means, in what manner, how exactly the mechanisms of DBS progression of motor-symptoms mainly reducing the tremors and motor fluctuations and then restoring and thereby increasing the motor functioning have not been fully elucidated. We implanted the DBS microelectrodes (DBS-innocuous-microelectrode stimulations), and also lead macroelectrodes (DBS-innocuous-lead macrostimulations) and find that the micro electrode recording (M.E.R) method provides validation of precise setting of innocuous micro electrode and guarantees exact exposure to the S.T.N neurons and confines and establishes its exact co-ordinates in a new empirical way.
A case of severe hypoglycemic encephalopathy
Authors: Balagopal Krishnan , Suku Sherin , Ebrahim Ameer
Published: March 2022

Hypoglycemic encephalopathy is a metabolic encephalopathy that usually occurs in diabetic patients and is due to low levels of blood glucose in the body. The clinical presentation varies in severity from mild cases presenting with fatigue, sweating and poor concentration to severe cases leading to stupor, coma and death. Diagnosis is often delayed due to inadequate recognition of the cause and diverse clinical picture. Imaging studies show characteristic changes in the cerebral cortex and deep grey nuclei. Management is mainly supportive.

We present here a case of a seventy five year old diabetic who was found lying unresponsive at home in the morning and was brought to the emergency. She was found to have very low levels of blood glucose which were corrected with no improvement in the sensorium. She was ventilated and treated with glucose infusions and supportive care. MRI scans of the brain showed features of extensive hypoglycemic encephalopathy with damage of the parietal and occipital cortices and also deep gray nuclei including thalami bilaterally. She had no change in clinical status after a prolonged hospital stay and succumbed to secondary infection.

Prolonged hypoglycemia leads to widespread neuronal damage through energy failure and apoptosis. This leads to prolonged coma and even death in severe cases. This case report is meant to stress the importance of early diagnosis and treatment in the long term outcome of hypoglycemic encephalopathy.

1. Hypoglycemic encephalopathy is an important clinical entity with a wide variety of clinical presentations; 2. We present here a case of a seventy five year old diabetic with a prolonged duration of hypoglycemia and severe hypoglycemic encephalopathy who had a poor outcome; 3. Early diagnosis and treatment are essential for good long term outcomes.
A construção do protocolo de enfermagem para operacionalizar o processo de enfermagem em Saúde Mental
Authors: Campos Fagner Alfredo Ardisson Cirino , Guedes Damiana , Feitosa Fabio Biasotto
Published: March 2022

Protocolos de saúde são recomendações desenvolvidas sistematicamente para auxiliar no manejo de um problema de saúde. Assim, para facilitar a operacionalização do processo de enfermagem em saúde mental, foi criado um protocolo especíﬁco em saúde mental. OBJETIVO: Apresentar a descrição da elaboração de um protocolo de enfermagem em um serviço de saúde mental comunitária. MÉTODO: Para tanto, por meio da pesquisa de relato de experiência foi construído o protocolo em três etapas: 1° Realização rodas de conversas, treinamentos e discussão em grupo com os enfermeiros do serviço, 2° Sensibilização da Gerência Geral e de Enfermagem, 3° Elaboração dos instrumentos e aprovação pela gerência de Enfermagem para implementação no CAPS AD II. RESULTADOS: Portanto, construímos um protocolo para operacionalizar o processo de enfermagem na saúde mental por meio de checklists, que possuíam as fases do processo de enfermagem: histórico de enfermagem, diagnósticos de enfermagem, resultados esperados, prescrições de enfermagem, avaliação de enfermagem, visita de enfermagem e um manual de utilização. CONCLUSÃO: Logo, é possível construir, aplicar e sistematizar o processo de enfermagem em uma instituição de saúde mental, por meio de um protocolo de enfermagem, o que pode melhorar o cuidado de enfermagem. Pois, houve maior acompanhamento, avaliação e revisão das prescrições/intervenções pelos enfermeiros, trabalho em equipe e efetividade na condução do PTS. Assim, os enfermeiros puderam contribuir para a reabilitação psicossocial de pacientes usuários de psicoativos.
The Influence of Significant Others on the Course of the Process of Leaving Sex Work
Authors: Ślęzak Izabela
Published: March 2022

The purpose of the article is to present the barriers to leaving sex work which are related to the influence of significant others on decisions made by sex workers. The analysis was applied in the case of two categories of significant others (organizational and intimate), which through interactions in escort agencies and on family grounds, respectively, may exert a destructive influence on sex workers’ intentions, referring to their life and the act of leaving sex work. Therefore, the relationships with significant others described in the article interfere in the process of these women’s identity transformation, hindering the development of a self-concept outside prostitution. The article is based on qualitative research carried out in escort agencies in one of the biggest Polish cities.
Age of menarche in girls with sight organ diseases
Authors: Umławska Wioleta
Published: March 2022

The paper attempts to clarify the reasons for sooner pubescence of girls with sight defects than that of their normally seeing peers. The age of menarche was considered depending on the degree of the sight impairment and the disease etiology as well as some selected factors of the socio-economic environment in the examined girls. families.
Formation of students’ communicative competence through game technology
Authors: Kargash Atymanova , Gulden Yespolova , Yerubay Baibekov , Akmara Berdaliyeva , Omarov Nurlybek , Nagashbek Zhilisbayev
Published: March 2022

The aim of this study is to determine the creation of communicative competencies of students with game technology. The research was conducted in the fall semester of 2021–2022; the research consists of 327 volunteer students studying at universities in Kazakhstan and continuing their education. According to the sub-objectives of the research, the use of gamification technologies by university students during the day, the time spent by university students using the Internet and the situations were focused on. In the scope of the study, descriptive statistical methods were used for the development of students' communicative competencies with the gamification technology of university students. The research is a quantitative research method and is designed according to the analysis of students' views on the formation of communicative competencies on gamification technologies. According to the results of the research, it has been concluded that communicative skills increase with game technology. In addition, according to the results of the research, it was concluded that university students use the time zone on the Internet on the spot.

 

Keywords: University students, gamification, communicative competence;
Pemahaman Konsep Fluida Statis dengan Contrasting Cases
Authors: Prahastiwi Rima Buana , Hidayat Arif , Sulasmi Eni
Published: March 2022

Tujuan penelitian ini adalah untuk mengetahui bagaimana proses pembelajaran dengan contrasting cases dan peningkatan pemahaman konsep siswa pada materi fluida statis setelah diberikan perlakuan pembelajaran dengan contrasting cases. Penggunaan contrasting cases bertujuan untuk memudahkan siswa dalam menemuan ciri penting dari suatu konsep sehingga terjadi peningkatan pemahaman konsep. Metode yang digunakan dalam penelitian ini yaitu dengan menggunakan Mixed Method: Embedded Experimental Design. Metode penelitian ini digunakan untuk memperoleh data proses pembelajaran dan pemahaman konsep siswa secara lengkap yang ditinjau dari sebelum perlakuan, proses yang dilakukan selama perlakuan, dan setelah perlakuan. Data diperoleh dengan melakukan observasi dan memberikan 12 soal pilihan ganda beralasan kepada 33 siswa SMA kelas XI IPA. Berdasarkan hasil penelitian diketahui proses pembelajaran dengan contrasting cases yang diamati oleh tiga observer memperoleh tingkat keberhasilan rata-rata 86,44% dari 100%. Untuk hasil dari pemahaman konsep fluida statis yang ditinjau dari statistik deskriptif yaitu terjadi peningkatan rata-rata skor prepost-test 2,67 ke 5,70. Berdasarkan hasil statistik deskriptif maka dapat dilakukan uji lanjut untuk mengetahui peningkatan pemahaman konsep dengan menggunakan perhitungan N-gain diperoleh skor 0,32 dengan kategori peningkatan pemahaman konsep sedang. Berdasarkan hasil penelitian dapat disimpulkan bahwa pembelajaran dengan contrasting cases dilakukan dengan baik dan terjadi peningkatan pemahaman konsep dengan kategori sedang. Untuk penelitian selanjutnya perlu adanya pembiasaan lebih lama dalam proses pembelajaran dengan contrasting cases agar siswa dapat dengan mudah menemukan ciri penting dari suatu konsep. Selain itu dalam melakukan pembiasaan dapat juga dikembangkan kasus yang dihadirkan dalam pembelajaran lebih terlihat kekonstrasannya dengan begitu diharapkan terjadi peningkatan pemahaman konsep yang lebih baik.
The Political Cartel of Presidential Candidacy through Threshold Brings Up a Single Candidate
Authors: Saad Muhammad , Sabrina Dian Fitri , Sukardi Sukardi
Published: March 2022

AbstractThe practice of presidential nomination by using a threshold through political parties or coalitions of political parties in Indonesia is still carried out because Indonesia adheres to a multi-party system. However, the regulation regarding the threshold for presidential nomination is prone to political transactions between parties. The reason is that there is no equality of access to presidential nominations between new political parties and old political parties considering that political parties are a defining element of representative democracy (Political parties are a defining element of representative democracy), this practice threatens the rights of minority political parties and limits the emergence of presidential candidates. The threshold in the nomination of President based on the decision of the Constitutional Court of the Republic of Indonesia Number 74/PUU/XVII/2020 regarding the review of Law Number 7 of 2017 concerning Elections is referred to as an open legal policy which is the authority of the House of Representatives in forming the Law on Elections. This study aims to evaluate the application of the threshold in the nomination of President with the principle of justice. This research is a doctrinal research using a case approach and a law approach. This study was conducted by looking at the development of the application of thresholds in elections and the provisions stipulated in the Election Law. The results of the study indicate that it is necessary to establish an ideal implementation model based on the principle of justice in order to guarantee the rights of minority political parties and avoid the emergence of a single presidential candidate.Keywords: Political Cartel; President Threshold; Single Candidate.
Implementation of social capital for multipurpose cooperative autonomy
Authors: Tjahjono Andik Fadjar , Mashud Mustain , Suaedi Falih
Published: March 2022

Only a few cooperatives succeed in utilizing social capital, one of them is the Setia Budi Wanita (SBW) Multipurpose Cooperative, East Java. This study aims to elaborate on social capital utilization that develops the autonomy of a multipurpose cooperative. The research method used was qualitative with a phenomenology approach in SBW Multipurpose Cooperative and data were collected through interviews, focused group discussions, and document review. This study has nine informants, including one East Java cooperative figure, four cooperative administrators, two existing members, and two new members. Various data were traced, among others: profiles of SBW figures, various women empowerment programs, the joint responsibility group system, and collaborative partnership between SBW Multipurpose Cooperative and the Department of Cooperatives and SMEs of East Java Province. The results show that SBW Multipurpose Cooperative has various social capital, among others: the characters of Mursia Zaafril Ilyas and Sri Untari Bisowarno, the bond of the seventeen doctors’ wives, a community of 360 members, and fourteen administrators of SBW; values and trust in the network of women’s cooperatives. This study concludes that social capital elements enable SBW Multipurpose Cooperative to be an autonomous cooperative. SBW Multipurpose Cooperative can utilize the collaboration of individual, community, and network social capital.