bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparing clinical responses and the biomarkers of BDNF and cytokines between subthreshold bipolar disorder and bipolar II disorder
Authors: Wang Tzu-Yun , Lee Sheng-Yu , Chen Shiou-Lan , Chang Yun-Hsuan , Wang Liang-Jen , Chen Po See , Chen Shih-Heng , Chu Chun-Hsien , Huang San-Yuan , Tzeng Nian-Sheng , Li Chia-Ling , Chung Yi-Lun , Hsieh Tsai-Hsin , Lee I Hui , Chen Kao Chin , Yang Yen Kuang , Hong Jau-Shyong , Lu Ru-Band
Published: June 2016

Patients with subthreshold hypomania (SBP; subthreshold bipolar disorder) were indistinguishable from those with bipolar disorder (BP)-II on clinical bipolar validators, but their analyses lacked biological and pharmacological treatment data. Because inflammation and neuroprogression underlies BP, we hypothesized that cytokines and brain-derived neurotrophic factor (BDNF) are biomarkers for BP. We enrolled 41 drug-naïve patients with SBP and 48 with BP-II undergoing 12 weeks of pharmacological treatment (valproic acid, fluoxetine, risperidone, lorazepam). The Hamilton Depression Rating Scale (HDRS) and Young Mania Rating Scale (YMRS) were used to evaluate clinical responses at baseline and at weeks 0, 1, 2, 4, 8, and 12. Inflammatory cytokines (tumour necrosis factor [TNF]-α, transforming growth factor [TGF]-β1, interleukin [IL]-6, IL-8 and IL-1β) and BDNF levels were also measured. Mixed models repeated measurement was used to examine the therapeutic effect and changes in BDNF and cytokine levels between the groups. HDRS and YMRS scores significantly (P < 0.001) declined in both groups, the SBP group had significantly lower levels of BDNF (P = 0.005) and TGF-β1 (P = 0.02). Patients with SBP and BP-II respond similarly to treatment, but SBP patients may have different neuroinflammation marker expression.
Complexity and Specificity of the Neutrophil Transcriptomes in Juvenile Idiopathic Arthritis
Authors: Hu Zihua , Jiang Kaiyu , Frank Mark Barton , Chen Yanmin , Jarvis James N.
Published: June 2016

NIH projects such as ENCODE and Roadmap Epigenomics have revealed surprising complexity in the transcriptomes of mammalian cells. In this study, we explored transcriptional complexity in human neutrophils, cells generally regarded as nonspecific in their functions and responses. We studied distinct human disease phenotypes and found that, at the gene, gene isoform, and miRNA level, neutrophils exhibit considerable specificity in their transcriptomes. Thus, even cells whose responses are considered non-specific show tailoring of their transcriptional repertoire toward specific physiologic or pathologic contexts. We also found that miRNAs had a global impact on neutrophil transcriptome and are associated with innate immunity in juvenile idiopathic arthritis (JIA). These findings have important implications for our understanding of the link between genes, non-coding transcripts and disease phenotypes.
Stromal fibroblasts derived from mammary gland of bovine with mastitis display inflammation-specific changes
Authors: Chen Qing , He Guiliang , Zhang Wenyao , Xu Tong , Qi Hongliang , Li Jing , Zhang Yong , Gao Ming-Qing
Published: June 2016

Fibroblasts are predominant components of mammary stromal cells and play crucial roles in the development and involution of bovine mammary gland; however, whether these cells contribute to mastitis has not been demonstrated. Thus, we have undertaken biological and molecular characterization of inflammation-associated fibroblasts (INFs) extracted from bovine mammary glands with clinical mastitis and normal fibroblasts (NFs) from slaughtered dairy cows because of fractured legs during lactation. The functional contributions of INFs to normal epithelial cells were also investigated by using an in vitro co-culture model. We present evidence that the INFs were activated fibroblasts and showed inflammation-related features. Moreover, INFs significantly inhibited the proliferation and β-casein secretion of epithelial cells, as well as upregulated the expression of tumor necrosis factor-α and interleukin-8 in epithelial cells. These findings indicate that functional alterations can occur in stromal fibroblasts within the bovine mammary gland during mastitis, demonstrating the importance of stromal fibroblasts in bovine mastitis and its treatment.
An Unroofing Method to Observe the Cytoskeleton Directly at Molecular Resolution Using Atomic Force Microscopy
Authors: Usukura Eiji , Narita Akihiro , Yagi Akira , Ito Shuichi , Usukura Jiro
Published: June 2016

An improved unroofing method enabled the cantilever of an atomic force microscope (AFM) to reach directly into a cell to visualize the intracellular cytoskeletal actin filaments, microtubules, clathrin coats and caveolae in phosphate-buffered saline (PBS) at a higher resolution than conventional electron microscopy. All of the actin filaments clearly exhibited a short periodicity of approximately 5–6 nm, which was derived from globular actins linked to each other to form filaments, as well as a long helical periodicity. The polarity of the actin filaments appeared to be determined by the shape of the periodic striations. Microtubules were identified based on their thickness. Clathrin coats and caveolae were observed on the cytoplasmic surface of cell membranes. The area containing clathrin molecules and their terminal domains was directly visualized. Characteristic ridge structures located at the surface of the caveolae were observed at high resolution, similar to those observed with electron microscopy (EM). Overall, unroofing allowed intracellular AFM imaging in a liquid environment with a level of quality equivalent or superior to that of EM. Thus, AFMs are anticipated to provide cutting-edge findings in cell biology and histology.
Transmission of Hand, Foot and Mouth Disease and Its Potential Driving Factors in Hong Kong
Authors: Yang Bingyi , Lau Eric H. Y. , Wu Peng , Cowling Benjamin J.
Published: June 2016

Hand-foot-and-mouth disease (HFMD) is a common childhood disease with substantial disease burden in Asia. Mixed results were reported on the associations between HFMD incidence and meteorological factors or school holidays, while limited studies focused on their association on transmissibility. We aimed to measure the transmissibility of HFMD and to examine its potential driving factors in Hong Kong. A likelihood-based procedure was used to estimate time-dependent effective reproduction number (Rt) based on weekly number of HFMD-associated hospitalizations from 2010 to 2014. The associations of between-year effects, depletion of susceptibles, absolute humidity and school holidays with Rt were examined using linear regression. Rt usually started increasing between early spring and summer and peaked in April to May at around 1.1–1.2, followed by a slight rebound in autumn. Depletion of susceptibles and between-years effects explained most of the variances (19 and 13% respectively) in Rt. We found a negative association between depletion of susceptibles and Rt (coefficients ranged from −0.14 to −0.03 for different years), but the estimated effects of absolute humidity and school holidays were insignificant. Overall, HFMD transmission was moderate in Hong Kong and was mainly associated with depletion of susceptibles. Limited impact was suggested from meteorological factors and school holidays.
Reversing diet-induced metabolic dysregulation by diet switching leads to altered hepatic de novo lipogenesis and glycerolipid synthesis
Authors: Kowalski Greg M. , Hamley Steven , Selathurai Ahrathy , Kloehn Joachim , De Souza David P. , O’Callaghan Sean , Nijagal Brunda , Tull Dedreia L. , McConville Malcolm J. , Bruce Clinton R.
Published: June 2016

In humans, low-energy diets rapidly reduce hepatic fat and improve/normalise glycemic control. Due to difficulties in obtaining human liver, little is known about changes to the lipid species and pathway fluxes that occur under these conditions. Using a combination of stable isotope and targeted metabolomic approaches we investigated the acute (7–9 days) hepatic effects of switching high-fat high-sucrose diet (HFD) fed obese mice back to a chow diet. Upon the switch, energy intake was reduced, resulting in reductions of fat mass and hepatic triacyl- and diacylglycerol. However, these parameters were still elevated compared to chow fed mice, thus representing an intermediate phenotype. Nonetheless, glucose intolerance and hyperinsulinemia were completely normalized. The diet reversal resulted in marked reductions in hepatic de novo lipogenesis when compared to the chow and HFD groups. Compared with HFD, glycerolipid synthesis was reduced in the reversal animals, however it remained elevated above that of chow controls, indicating that despite experiencing a net loss in lipid stores, the liver was still actively esterifying available fatty acids at rates higher than that in chow control mice. This effect likely promotes the re-esterification of excess free fatty acids released from the breakdown of adipose depots during the weight loss period.
Advanced uracil DNA glycosylase-supplemented real-time reverse transcription loop-mediated isothermal amplification (UDG-rRT-LAMP) method for universal and specific detection of Tembusu virus
Authors: Tang Yi , Chen Hao , Diao Youxiang
Published: June 2016

Tembusu virus (TMUV) is a mosquito-borne flavivirus which threatens both poultry production and public health. In this study we developed a complete open reading frame alignment-based rRT-LAMP method for the universal detection of TUMV. To prevent false-positive results, the reaction was supplemented with uracil DNA glycosylase (UDG) to eliminate carryover contamination. The detection limit of the newly developed UDG-rRT-LAMP for TMUV was as low as 100 copies/reaction of viral RNA and 1 × 100.89 − 1 × 101.55 tissue culture infectious dose/100 μL of viruses. There were no cross-reactions with other viruses, and the reproducibility of the assay was confirmed by intra- and inter-assay tests with variability ranging from 0.22–3.33%. The new UDG-rRT-LAMP method for TMUV produced the same results as viral isolation combined with RT-PCR as the “gold standard” in 96.88% of cases for 81 clinical samples from subjects with suspected TMUV infection. The addition of UDG can eliminate as much as 1 × 10−16 g/reaction of contaminants, which can significantly reduce the likelihood of false-positive results during the rRT-LAMP reaction. Our result indicated that our UDG-rRT-LAMP is a rapid, sensitive, specific, and reliable method that can effectively prevent carryover contamination in the detection of TMUV.
Higher reward value of starvation imagery in anorexia nervosa and association with the Val66Met BDNF polymorphism
Authors: Clarke J , Ramoz N , Fladung A-K , Gorwood P
Published: June 2016

Recent studies support the idea that abnormalities of the reward system contribute to onset and maintenance of anorexia nervosa (AN). Next to cues coding for overweight, other research suggest cues triggering the proposed starvation dependence to be pivotally involved in the AN pathogenesis. We assessed the characteristics of the cognitive, emotional and physiologic response toward disease-specific pictures of female body shapes, in adult AN patients compared with healthy control (HC) women. Frequency and amplitude of skin conductance response (SCR) in 71 patients with AN and 20 HC were registered during processing of stimuli of three weight categories (over-, under- and normal weight). We then assessed the role of the Val66Met BDNF polymorphism as a potential intermediate factor. AN patients reported more positive feelings during processing of underweight stimuli and more negative feelings for normal- and overweight stimuli. The SCR showed a group effect (P=0.007), AN patients showing overall higher frequency of the response. SCR within patients was more frequent during processing of underweight stimuli compared with normal- and overweight stimuli. The Met allele of the BDNF gene was not more frequent in patients compared with controls, but was associated to an increased frequency of SCR (P=0.008) in response to cues for starvation. A higher positive value of starvation, rather than more negative one of overweight, might more accurately define females with AN. The Met allele of the BDNF gene could partly mediate the higher reward value of starvation observed in AN.
A greener flow injection method based on a LWCC for the screening of tetracycline antibiotics in bovine milk samples
Authors: Rodríguez Michael Pérez , Ferreira da Silva Bianca , Pezza Helena Redigolo , Pezza Leonardo
Published: June 2016

An easy and greener flow injection method was developed for the spectrophotometric screening of tetracycline antibiotic residues in bovine milk.
Determination of α-tocopherol in cereal grains by use of saponification coupled with ionic-liquid-based dispersive liquid–liquid microextraction before high-performance liquid chromatography-mass spectrometry
Authors: Xie Qilong , Sun Dekui , Cao Jiangping , Jia Litao , Hou Bo , Li Debao
Published: June 2016

A selective and low organic-solvent-consuming method of sample preparation combined with high-performance liquid chromatography-mass spectrometry detection is introduced for the analysis of α-tocopherol in cereal grains.
Studies on electrochemical organophosphate pesticide (OP) biosensor design based on ionic liquid functionalized graphene and a Co3O4nanoparticle modified electrode
Authors: Zheng Yingying , Liu Zhimin , Zhan Haijun , Li Jie , Zhang Chengcheng
Published: June 2016

In this study, a new type of organophosphate pesticide (OP) biosensor was successfully fabricated based on the immobilization of acetylcholinesterase (AChE) by cross-linking on a glassy carbon electrode (GCE) modified with ionic liquid functionalized graphene (IL-GR), Co3O4nanoparticles and chitosan (CHI).
Nonenzymatic electrochemical detection of rutin on Pt nanoparticles/graphene nanocomposite modified glassy carbon electrode
Authors: Li Shumin , Yang Beibei , Wang Jin , Bin Duan , Wang Caiqin , Zhang Ke , Du Yukou
Published: June 2016

In this article, a nonenzymatic electrochemical sensor based on chemically reduced graphene oxide (RGO) and a Pt nanoparticles (PtNPs) modified glassy carbon electrode has been fabricated and used to determine rutin.
Carbogenically coated silica nanoparticles and their forensic applications
Authors: Fernandes D. , Krysmann M. J. , Kelarakis A.
Published: June 2016

The color-tunable C-SiO2 are ideal powders for fingerprint enhancement, and they can also generate self-assembled nanotags suitable for object authentication.
Recent progress in stimuli-induced polydiacetylenes for sensing temperature, chemical and biological targets
Authors: Lee Songyi , Kim Ji-Yeong , Chen Xiaoqiang , Yoon Juyoung
Published: June 2016

In this feature article, we covered recent progress in stimuli-induced polydiacetylenes for sensing temperature, chemical and biological targets.
Synthesis of models of the BC ring systems of MPC1001 and MPC1001F
Authors: Dong Shuai , Indukuri Kiran , Clive Derrick L. J. , Gao Jin-Ming
Published: June 2016

Piperazinedione and piperazinetrione systems representing the BC rings of several members of the MPC1001 family of fungal metabolites were synthesized.
Mechanothermally induced conformational switch of a porphyrin dimer in a polymer film
Authors: Doan Hung , Raut Sangram L. , Yale David , Balaz Milan , Dzyuba Sergei V. , Gryczynski Zygmunt
Published: June 2016

Stretching of the polymer film induces a conformational change in the embedded porphyrin dimer.
The effect of ionic Co presence on the structural, optical and photocatalytic properties of modified cobalt–titanate nanotubes
Authors: Barrocas B. , Silvestre A. J. , Rolo A. G. , Monteiro O. C.
Published: June 2016

With the aim of producing materials with enhanced optical and photocatalytic properties, titanate nanotubes (TNTs) modified by cobalt doping (Co-TNT) and by Na+ → Co ion-exchange (TNT/Co) were successfully prepared by a hydrothermal method.
Novel Schiff-base molecules as efficient corrosion inhibitors for mild steel surface in 1 M HCl medium: experimental and theoretical approach
Authors: Saha Sourav Kr. , Dutta Alokdut , Ghosh Pritam , Sukul Dipankar , Banerjee Priyabrata
Published: June 2016

In order to evaluate the effect ofthe functional group present in the ligand backbone towards corrosion inhibition performances, three Schiff-base molecules were synthesized and used as corrosion inhibitors on mild steel in 1 M HCl medium.
The photoluminescence mechanism of ultra-small gold clusters
Authors: Wu Liangliang , Fang Weihai , Chen Xuebo
Published: June 2016

The photoluminescence mechanism of ultra-small gold clusters was proposed to reveal the origin of excited states formed by aurophilic interactions and their radiative decays.
Spectacular enhancement of thermoelectric phenomena in chemically synthesized graphene nanoribbons with substitution atoms
Authors: Zberecki K. , Swirkowicz R. , Wierzbicki M. , Barnaś J.
Published: June 2016

We analyze theoretically the transport and thermoelectric properties of graphene nanoribbons of a specific geometry, which have been synthesized recently from polymers [Cai, et al., Nature, 2011, 466, 470].
The rise of organic electrode materials for energy storage
Authors: Schon Tyler B. , McAllister Bryony T. , Li Peng-Fei , Seferos Dwight S.
Published: June 2016

We review organic electrode materials for energy storage devices and suggest directions for future work in this area.
TiO2@h-CeO2: a composite yolk–shell microsphere with enhanced photodegradation activity
Authors: Yuan Bing , Long Yu , Wu Li , Liang Kun , Wen He , Luo Sha , Huo Hongfei , Yang Honglei , Ma Jiantai
Published: June 2016

A yolk–shell composite microsphere, TiO2@h-CeO2, has been designed, synthesized, characterized and applied in the photodegradation of methylene blue.
Synergistic oxygen atom transfer by ruthenium complexes with non-redox metal ions
Authors: Lv Zhanao , Zheng Wenrui , Chen Zhuqi , Tang Zhiming , Mo Wanling , Yin Guochuan
Published: June 2016

This study demonstrates the first example wherein non-redox metal ions as Lewis acids sharply improve the catalytic oxygen atom transfer efficiency of a ruthenium complex.
Materials informatics: a journey towards material design and synthesis
Authors: Takahashi Keisuke , Tanaka Yuzuru
Published: June 2016

Issues involving database management, implementing machine learning, and platform design for materials informatics are discussed with potential solutions.
Stimuli-responsive metal-directed self-assembly of a ring-in-ring complex
Authors: Alvariño Cristina , Platas-Iglesias Carlos , Blanco Víctor , García Marcos D. , Peinador Carlos , Quintela José M.
Published: June 2016

The threading and unthreading process of a dinuclear metallacycle into a ring-in-ring structure can be controlled by temperature, dilution, and medium polarity.
Further studies of the Enhanced Structural Carborane Effect: tricarbonylruthenium and related derivatives of benzocarborane, dihydrobenzocarborane and biphenylcarborane
Authors: Powley Samuel L. , Rosair Georgina M. , Welch Alan J.
Published: June 2016

{Ru(CO)3} derivatives and related compounds of benzocarborane, dihydrobenzocarborane and biphenylcarborane have been prepared and characterised.
Trends analyses of 30 years of ambient 8 hour ozone and precursor monitoring data in the South Central U.S.: progress and challenges
Authors: Sather Mark E. , Cavender Kevin
Published: June 2016

30 years of progress in reducing ambient ozone and precursor concentrations in the South Central U.S.
Challenges in nanoelectrochemical and nanomechanical studies of individual anisotropic gold nanoparticles
Authors: Knittel P. , Bibikova O. , Kranz C.
Published: June 2016

The characterization of nanoparticles and the correlation of physical properties such as size and shape to their (electro)chemical properties is an emerging field, which may facilitate future optimization and tuning of devices involving nanoparticles. This requires the investigation of individual particles rather than obtaining averaged information on large ensembles. Here, we present atomic force – scanning electrochemical microscopy (AFM-SECM) measurements of soft conductive PDMS substrates modified with gold nanostars (i.e., multibranched Au nanoparticles) in peak force tapping mode, which next to the electrochemical characterization provides information on the adhesion, deformation properties, and Young's modulus of the sample. AFM-SECM probes with integrated nanodisc electrodes (radii < 50 nm) have been used for these measurements. Most studies attempting to map individual nanoparticles have to date been performed at spherical nanoparticles, rather than highly active asymmetric gold nanoparticles. Consequently, this study discusses challenges during the nanocharacterization of individual anisotropic gold nanostars.
Phenolic compounds and biological effects of edible Rumex scutatus and Pseudosempervivum sempervivum: potential sources of natural agents with health benefits
Authors: Savran Ahmet , Zengin Gokhan , Aktumsek Abdurrahman , Mocan Andrei , Glamoćlija Jasmina , Ćirić Ana , Soković Marina
Published: June 2016

The present study outlines a chemical characterization and further effects beneficial to health of edible Rumex scutatus and Pseudosempervivum sempervivum.
Biomass-derived carbon: synthesis and applications in energy storage and conversion
Authors: Deng Jiang , Li Mingming , Wang Yong
Published: June 2016

Plenty of biomass has served as raw materials in the synthesis of various carbon materials, which provide possibilities to satisfy different applications in the area of energy.
Reductive splitting of hemicellulose with stable ruthenium-loaded USY zeolites
Authors: Ennaert Thijs , Feys Simon , Hendrikx Don , Jacobs Pierre A. , Sels Bert F.
Published: June 2016

Precisely balancing of the location, amount and strength of the acid and metal function on a bifunctional zeolite catalyst is essential for selective sugar alcohol formation.
Elementary and systemic views of the generation of toxic substances
Authors: Wakaki Takayuki , Oisaki Kounosuke , Kanai Motomu
Published: June 2016

The generation and utilisation of toxic side-products is discussed in this Editorial, part of a series celebrating the Twelve Principles of Green Chemistry.
RF-Hydroxysite: a random forest based predictor for hydroxylation sites
Authors: Ismail Hamid D. , Newman Robert H. , KC Dukka B.
Published: June 2016

Protein hydroxylation is an emerging posttranslational modification involved in both normal cellular processes and a growing number of pathological states, including several cancers.
Virucidal activity of human α- and β-defensins against hepatitis C virus genotype 4
Authors: Mattar Ehab H. , Almehdar Hussein A. , Uversky Vladimir N. , Redwan Elrashdy M.
Published: June 2016

We revealed that human α- and β-defensins have strong anti-HCV activity in experiments on cellular protection, neutralization, and treatment at low concentrations, whereas synthetic linear avian defensins could reach similar anti-HCV potential only at noticeably higher concentrations.
Thiol–ene click chemistry for the design of diol porous monoliths with hydrophilic surface interaction ability: a capillary electrochromatography study
Authors: Kebe Seydina Ibrahima , Ben Boubaker Meyssoun , Guerrouache Mohamed , Carbonnier Benjamin
Published: June 2016

Thiol–ene click chemistry provides an efficient surface grafting strategy for designing diol monoliths meant for hydrophilic interaction capillary electrochromatography.
Charge transfer at carbon nanotube–graphene van der Waals heterojunctions
Authors: Liu Yuanda , Wang Fengqiu , Liu Yujie , Wang Xizhang , Xu Yongbing , Zhang Rong
Published: June 2016

Carbon nanotubes and graphene are two most widely investigated low-dimensional materials for photonic and optoelectronic devices.
Scalable procedure for the fragmentation of hydroperoxides mediated by copper and iron tetrafluoroborate salts
Authors: Huang David , Schuppe Alexander W. , Liang Michael Z. , Newhouse Timothy R.
Published: June 2016

An improved protocol for the formal elimination of propene from organic substrates is reported.
Enantioselective synthesis of chiral α,β-unsaturated γ-substituted butyrolactams by organocatalyzed direct asymmetric vinylogous Michael addition of α,β-unsaturated γ-butyrolactam to 2-enoylpyridines
Authors: Wang Zhen-Hua , Wu Zhi-Jun , Yue Deng-Feng , You Yong , Xu Xiao-Ying , Zhang Xiao-Mei , Yuan Wei-Cheng
Published: June 2016

Approach providing a series of optically active α,β-unsaturated γ-substituted butyrolactams in high yields with excellent diastereo- and enantioselectivities.
An amphiphilic block copolymer conjugated with carborane and a NIR fluorescent probe for potential imaging-guided BNCT therapy
Authors: Ruan Zheng , Liu Le , Fu Liyi , Xing Tao , Yan Lifeng
Published: June 2016

A carborane-containing triblock copolymer conjugated with a near infrared (NIR) fluorescence probe has been synthesized via reversible addition fragmentation chain transfer (RAFT), ring open polymerization (ROP), and conjugations of a cyanine NIR dye.
Glycopeptides derived from glucosaminic acid
Authors: Abtew Ester , Domb Abraham J. , Basu Arijit
Published: June 2016

A new class of polymers that resemble a peptidic backbone with pendant sugar side chains.
Design and development of a piscine collagen blended pullulan hydrogel for skin tissue engineering
Authors: S. Iswariya , A. V. Bhanukeerthi , Velswamy Poornima , T. S. Uma , Perumal Paramasivan Thirumalai
Published: June 2016

This present study was designed to prepare a super-absorbent tailor-made collagen–pullulan hydrogel with improved mechanical stability and well-defined biocompatibility for skin tissue engineering.
A study on the differences in morphology and corrosion resistance performance between two different bis(2-ethylhexyl) phosphate self-assembled thin films prepared on an iron substrate in water and ethanol solvents
Authors: Yan Ru , Gao Xiang , Lv Dandan , Ma Houyi
Published: June 2016

BEPE SAMs formed on the iron surface by both electrostatic interaction and chemical covalent binding with island-like surface morphology, while the BEPW SAMs formed only through P–O–Fe bond with nodule-like appearance.
The influence of nanostructure size on V2O5electrochemical properties as cathode materials for lithium ion batteries
Authors: Prześniak-Welenc M. , Karczewski J. , Smalc-Koziorowska J. , Łapiński M. , Sadowski W. , Kościelska B.
Published: June 2016

The influence of the V2O5nanostructure size on the aggregation process and their electrochemical properties.
Highly stable naphthalene core based novel cleft-shaped strain molecule: influence of intermolecular H-bonding architectures
Authors: Panja Sumit Kumar , Dwivedi Nidhi , Saha Satyen
Published: June 2016

High thermal stability of a 8 membered naphthalene core based fused nitrogen bridged 1,5-dioxocin is found to be due to the coexistence of several weak interactions. Catalytic property of this molecule for a condensation reaction is also explored.
Spectral investigations, inhibition efficiency analysis and a TD-DFT study on tuning the light harvesting efficiency (LHE) of heterocyclic 5-nitro-1,3-benzodioxole as a photosensitizer for dye sensitized solar cells (DSSCs)
Authors: Meenakshi R.
Published: June 2016

The vibrational wavenumber of 5-nitro-1,3-benzodioxole (NBD) are obtained and the complete assignments are performed on the basis of the total energy distribution (TED) of the vibrational modes.
Protein patterns template arrays of magnetic nanoparticles
Authors: Nayak Srikanth , Zhang Honghu , Liu Xunpei , Feng Shuren , Palo Pierre , Nilsen-Hamilton Marit , Akinc Mufit , Mallapragada Surya
Published: June 2016

Pattern generation process for growth of magnetite nanoparticles (MNP), using patterns of octadecane thiol and poly(ethylene glycol) to selectively immobilize the biomineralization protein Mms6 and selectively form on the immobilized Mms6.
Aqueous processable WO3−xnanocrystals with solution tunable localized surface plasmon resonance
Authors: Balitskii Olexiy A. , Moszyński Dariusz , Abbas Zareen
Published: June 2016

The strategy of spherically shaped WO3−xNCs plasmonic absorbance tuning shown here is applicable to either the qualitative or quantitative sensing of basic or acidic ambient.
Magnetic solid-phase extraction based on ferroferric oxide nanoparticles doubly coated with chitosan and β-cyclodextrin in layer-by-layer mode for the separation of ibuprofen
Authors: Chen Pengfei , Song Hang , Zhou Lu , Chen Jun , Liu Jiyang , Yao Shun
Published: June 2016

Chitosan and β-cyclodextrin doubly coated with Fe3O4 nanoparticles was prepared and applied as magnetic solid-phase extraction adsorbent to separate ibuprofen.
Template-free syntheses of hierarchical PbS microstructures using a new sulphur source and their time-dependent morphological evolution and photocatalytic properties
Authors: Kaur Manjodh , Nagaraja C. M.
Published: June 2016

Template-free PbS microstructures composed of nanocrystals exhibiting time-dependent morphological evolution from cubes to dendrites were synthesised by one-pot solvothermal route using DBDS as a new temperature controlled in situ source of S2− ions.
One-step synthesis of silver metallosurfactant as an efficient antibacterial and anticancer material
Authors: Kaur Gurpreet , Kumar Sandeep , Kant Ravi , Bhanjana Gaurav , Dilbaghi Neeraj , Guru Santosh Kumar , Bhushan Shashi , Jaglan Sundeep
Published: June 2016

A silver based double chained metallosurfactant was synthesized and characterized with various analytical methods. Along with the self aggregation behavior, DNA binding abilities of metallomicelles and antimicrobial and anticancer activities were evaluated.
Ni-SMTU@boehmite: as an efficient and recyclable nanocatalyst for oxidation reactions
Authors: Ghorbani-Choghamarani Arash , Moradi Parisa , Tahmasbi Bahman
Published: June 2016

An efficient heterogenized nickel catalyst on boehmite nanoparticles was synthesized and characterized. The catalytic activity of this organometallic catalyst was examined in the selective oxidation of sulfides and oxidative coupling of thiols.
Surface passivation of carbon nanoparticles with p-phenylenediamine towards photoluminescent carbon dots
Authors: Craciun A. M. , Diac A. , Focsan M. , Socaci C. , Magyari K. , Maniu D. , Mihalache I. , Veca L. M. , Astilean S. , Terec A.
Published: June 2016

New photoluminescent carbon dots with intriguing photoluminescent properties were prepared from carboxylated carbon nanoparticles via covalent bonding of p-phenylenediamine oligomers.
A new organic NLO material isonicotinamidium picrate (ISPA): crystal structure, structural modeling and its physico-chemical properties
Authors: Jauhar RO. MU. , Viswanathan V. , Vivek P. , Vinitha G. , Velmurugan D. , Murugakoothan P.
Published: June 2016

A new organic nonlinear optical material isonicotinamidium picrate, with excellent nonlinear optical activity and thermal stability has been reported.
Hydrogen influence on generalized stacking fault energies of Zr {0001} basal plane: a first-principles study
Authors: Hou Songjun , Lei Huaping , Zeng Zhi
Published: June 2016

The influence of hydrogen on the Generalized Stacking Fault (GSF) energies of the {0001} basal plane along the 〈101̄0〉 and 〈112̄0〉 directions in HCP Zr has been investigated by using the first-principles calculations and the chemical bonding analysis.
Methotrexate anchored carbon dots as theranostic probes: digitonin conjugation enhances cellular uptake and cytotoxicity
Authors: Krishna A. Shanti , Radhakumary C. , Priya S. S. , Ramesan Rekha M. , Sreenivasan K.
Published: June 2016

Digitonin conjugation significantly improves the theranostic potential of methotrexate amended carbon dots.
Enhanced surface and interface diffusion in Ni–Bi bilayers by swift heavy ion irradiation
Authors: Siva Vantari , Chettah Abdelhak , Satpati Biswarup , Ojha S. , Kanjilal D. , Sahoo Pratap K.
Published: June 2016

Enhanced surface and interface diffusion in Ni–Bi bilayers has been observed using 100 MeV Au ion irradiation. The experimental observations were demonstrated using thermal spike model calculations.
Synthesis of blocked waterborne polyurethane polymeric dyes with tailored molecular weight: thermal, rheological and printing properties
Authors: Mao Haiyan , Wang Youjiang , Yao Donggang , Wang Chaoxia , Sun Shiguo
Published: June 2016

The structure–property relationship of the polymeric dyes with tailored molecular weight including rheological, thermal, and printing properties are mainly investigated.
The effect of wall depletion and hydrodynamic interactions on stress-gradient-induced polymer migration
Authors: Rezvantalab Hossein , Zhu Guorui , Larson Ronald G.
Published: June 2016

Predicting the stress-gradient-induced migration of polymers in presence of solid boundaries: continuum theory and mesoscopic simulations.
A novel long-lasting antifouling membrane modified with bifunctional capsaicin-mimic moieties via in situ polymerization for efficient water purification
Authors: Zhang Lili , Xu Jia , Tang Yuanyuan , Hou Jingwei , Yu Liangmin , Gao Congjie
Published: June 2016

Capsaicin-mimic materials are promising candidates for antifouling membrane fabrication.
Self-assembled gold nanostar–NaYF4:Yb/Er clusters for multimodal imaging, photothermal and photodynamic therapy
Authors: He Liangcan , Dragavon Joseph , Cho Suehyun , Mao Chenchen , Yildirim Adem , Ma Ke , Chattaraj Rajarshi , Goodwin Andrew P. , Park Wounjhang , Cha Jennifer N.
Published: June 2016

A grand challenge for medicine is to develop tools to selectively image and treat diseased cells.
Temperature responsive polymer brushes grafted from graphene oxide: an efficient fluorescent sensing platform for 2,4,6-trinitrophenol
Authors: Song Yajiao , Lü Jianhua , Liu Bingxin , Lü Changli
Published: June 2016

The block copolymer brushes of PNIPAM-b-P(MQ-co-GMA) were grafted from GO by RAFT polymerization. The resulting luminescent hybrid containing Alq3exhibited a robust temperature-responsive behavior and could be used as a nano-platform for the sensitive and selective detection of TNP.
Silica encapsulated fluorescein as a hybrid dye for blue-LED based lighting devices
Authors: Boonsin R. , Chadeyron G. , Roblin J.-P. , Boyer D. , Mahiou R.
Published: June 2016

Fluorescein–silica nanoparticles as hybrid dyes were prepared by a reverse microemulsion method.
SiTe monolayers: Si-based analogues of phosphorene
Authors: Chen Yu , Sun Qiang , Jena Puru
Published: June 2016

As a Si-based analogue of phosphorene, the α-SiTe monolayer shows a high degree of flexibility in energy band engineering.
Salvianolic acid B protects against doxorubicin induced cardiac dysfunction via inhibition of ER stress mediated cardiomyocyte apoptosis
Authors: Chen Rongchang , Sun Guibo , Yang Longpo , Wang Jian , Sun Xiaobo
Published: June 2016

Salvia miltiorrhiza Bunge is a well-known medicinal plant in China.
Multiplexed control strategy for a multi‐input converter using fuzzy logic algorithm
Authors: Hanif Noor‐ul‐Ain , Kashif S.A.R. , Saqib M.A.
Published: June 2016

The design analysis of a multi‐input converter using an intelligent controller based on fuzzy logic control algorithm is encompassed. The use of dedicated dc–dc converters is going through a transitory phase in smart‐grid applications. Different characteristics of inputs can be combined to give desired output operation by using a multi‐input converter which is more or less the combination of individual converters sharing a common load thus simultaneously transferring power to the load. The converter with the help of an intelligent algorithm will ensure the buffering time for each input thus multiplexing between various inputs according to the set demand and fluctuating conditions on the input side. Such a converter will behave as a power electronic interface between the utility, user and the renewable energy sources. A three‐input cuk converter has been designed for interfacing wind energy sources with the dc load bus and the main grid. Sending power to the main grid incorporates the power quality enhancement features which will be accommodated using the bi‐directional inverter connected with the grid to perform the active filtration. Moreover, three fuzzy logic controllers will set the output currents corresponding to each input current by changing their reference voltages according to the power demand.
Busting myths of energy models for wireless sensor networks
Authors: Harrison D.C. , Burmester D. , Seah W.K.G. , Rayudu R.
Published: June 2016

When developing and validating algorithms and protocols for wireless sensor networks, simulations provide valuable insights that would be impractical to gather from real world experimental deployments. For these simulations to be meaningful, realistic models of the way energy is consumed in the targeted sensor devices need to be produced. A number of inaccuracies are identified to avoid when constructing simulation energy models and in doing so draw attention to a device specific behaviour with the potential to invalidate research assumptions.
Wide‐band CPW‐fed slot antenna with parasitic directors for end‐fire radiation
Authors: Basit Muhammad Abdul , Wen Guangjun , Ping Wang
Published: June 2016

In this study a novel slot array antenna backed by a metallic reflector has been presented which produces end‐fire radiation. Several slots with different dimensions were etched in the ground plane of a thin substrate. Only first two slots were fed directly by a coplanar waveguide feed line while the other slots radiate by the mechanism of parasitic coupling. The simulation results show that the proposed antenna is capable of producing tilted end‐fire beam in a wide frequency band ranging from 12 to 18 GHz. The fractional impedance bandwidth of the antenna was found to be 40%. A prototype of the design was also fabricated and measurements were taken. It was found that the simulated results for the return loss, radiation pattern and gain of the antenna are close to the measured ones. The peak measured gain was found to be 10 dB while the maximum gain in exact end‐fire direction is almost 2 dB. As the radiating elements are slots therefore the antenna can be flush mounted in the conducting surface of an airborne vehicle. Moreover, due to the small thickness of substrate the antenna can be easily designed for conformal applications.
Focus improvement of highly squint bistatic synthetic aperture radar based on non‐linear chirp scaling
Authors: Li Yu , Huang Puming , Lin Chenchen
Published: June 2016

Synthetic aperture radar imaging at high resolution and highly squint angle is confronted with several difficulties, such as the spatial variance of range cell migration (RCM) and the azimuth‐dependent property of high‐order terms. In order to address the above‐mentioned problems, an improved non‐linear chirp scaling algorithm based on keystone transform (KT) and linear range walk correction (LRWC) is proposed. First, KT is applied to correct the second‐order RCM in range frequency and azimuth time domain. Then the spatial variance of linear RCM (LRCM) is analysed, and range–azimuth coupling is alleviated through LRWC, in this way, azimuth‐variant RCM can be removed by phase multiplication, which avoids the approximate error of RCMC in two‐dimensional frequency domain. Taking both the spatial variance of LRCM and the difference of the minimum bistatic slant range caused by LRWC into consideration, high‐precision approximation of azimuth‐dependent coefficients for azimuth signal are deduced, based on which the Doppler centroid, azimuth FM rate and cubic phase can be equalised by selecting proper perturbation coefficients. The proposed algorithm leads to a large depth of focusing in both range direction and azimuth direction. Simulation results prove the effectiveness of the proposed method.
Ein Hoch auf den Wagemut
Authors: Kohrs Jens
Published: June 2016

Wer Dinge bewegen und verändern möchte, muss etwas wagen. Genau das haben die FKT-Verantwortlichen mit ihrem Messedebüt in Gelsenkirchen im April getan. Angesichts der Vielzahl an etablierten Messen, Kongressen, Fachtagungen und Symposien im Gesundheitssektor hätte das mit dem Wagnis, ein neues, eigenes Branchentreffen zu initiieren, leicht schief gehen können – ist es aber nicht. Gratulation, nur wer wagt … – aber das kennen Sie ja.

Pioniergeist zeigen auch 50 Klimamanager, die sich in ihren Kliniken dem Energiesparen widmen. Dabei geht es auch darum, eigene Spielräume auszunutzen und die Regeln hier und da einmal etwas weiter auszulegen – natürlich immer im Rahmen des Erlaubten. Vielleicht – Achtung, Wortspiel – macht es dann ja auch bei den Kollegen oder Vorgesetzten „KLIK“ (Auflösung ab Seite 23).

Weniger Spielraum, dafür mehr Handlungsdruck offenbart sich beim Blick auf die Brandschutz-Strategien vieler Kliniken. Wer Menschen wie Thomas Nöckel genau zuhört (Seite 31), kann ziemlich unruhig werden. Aber der Risikomanager zeigt auch Wege aus der Gefahrenzone. In diesem Sinne: Verlieren Sie Ihre Ziele nicht aus den Augen – und seien Sie mutig.
WGKT-Tagung Technik im Krankenhaus TK 2016: Von IBM und Helios lernen
Authors: Kohrs Jens
Published: June 2016

Die Digitalisierung hat längst auch das Gesundheitswesen erfasst. Doch was in der medizinischen Anwendung tief und in der Medizintechnik zumindest ansatzweise etabliert ist, spielt in der konventionellen Technik bisher eine untergeordnete Rolle. Die TK 2016 in Leipzig soll das ändern.
Messe-Nachlese der FKT-Spitze: „Unsere Erwartungen wurden übertroffen“
Authors: Kohrs Jens
Published: June 2016

Für die FKT-Präsidenten Horst Träger und Wolfgang Siewert sowie Schatzmeister Christoph Franzen war ihre erste eigene Fachmesse ein voller Erfolg. Mit welchen Schwierigkeiten sie zu kämpfen hatten und wie es weitergehen soll, erzählen sie hier.
Risikomanagement: Plädoyer für Sprinkler
Authors: Nöckel Thomas
Published: June 2016

Es ist ein Horrorszenario: ein Brand in einem Krankenhaus. In ihrer Mobilität eingeschränkte Patienten geraten in Lebensgefahr, hohe Werte können vernichtet werden, Teile der Klinik drohen, länger auszufallen. Konsequentes Risikomanagement mindert die Gefahren.
High-Resolution Sonography as an Additional Diagnostic and Prognostic Tool to Monitor Disease Activity in Leprosy: A Two-Year Prospective Study
Authors: Chaduvula Meher , Visser Leo , Suneetha Sujai , Suneetha Lavanya , Devaraju Balakrishna , Ellanti Ramesh , Raju Renuka , Jain Suman
Published: June 2016

Purpose Early diagnosis and treatment of leprosy and leprosy reactions are essential to prevent stigmatizing deformities and disability. Although the incidence of leprosy has decreased enormously, grade 2 disability due to nerve injury has remained the same. New tools are needed to better diagnose and monitor leprosy reactions and associated neuritis and this study assessed whether high-resolution sonography (HRUS) can be used as such a tool.

Materials and Methods During a prospective follow-up period of 2 years at regular intervals, we performed clinical examination to assess sensory and motor function and HRUS of the four main peripheral nerves in 57 patients, of whom 36 were with reactions and 21 were without reactions. Normative data of the cross-sectional area (CSA) of these nerves were obtained from 55 healthy subjects (HS). Color Doppler (CD) was used to study blood flow in the nerves.

Results At the baseline visit and during follow-up, all four nerves were significantly thicker in patients with leprosy reactions in comparison to HS (p < 0.0001) and to a lesser extent also in comparison to patients without reactions ranging from a p-value of < 0.05 to < 0.0001 in the different nerves tested. During follow-up, the nerve size did not change significantly in patients without reactions, while it decreased significantly in patients with reactions. At baseline, endoneural blood flow was present only in patients with reactions. This occurred in 20 of the 36 (55 %) patients (49 nerves) and decreased to only 1 patient (2.7 %) at the end of the follow-up period.

Conclusion This prospective study demonstrates the ability of HRUS to monitor disease activity and the effect of treatment in patients with leprosy reactions by determining changes in nerve size and vascularity, which are indicators of peripheral nerve involvement and damage.
Stretching the boundaries: language learning psychology
Authors: Mercer Sarah , Ryan Stephen
Published: June 2016

In this article, we trace the story of a newly emerging field of study and the role of interdisciplinarity in its development. As the name suggests, the psychology of language learning is a field that connects the two disciplines of psychology and language learning, but it also encompasses other disciplines as diverse as communication studies, education studies and cultural studies. As a recognizable, independent field of enquiry with an established community of scholars, it is still in its infancy. However, its short history reveals key issues relating to the nature of interdisciplinarity and the struggles of a new interdiscipline to emerge and gain acceptance. We hope that this article will simultaneously serve as a call to like-minded scholars in our field to adopt a more overtly interdisciplinary approach and as a plea for recognition and support within the established community of interdisciplinarians. Although our core narrative may be a familiar one to expert interdisciplinarians, we still believe that the specifics of our account represent an original contribution to understanding the processes of an emerging interdiscipline. To help position this article and the discussions within, we will begin with a brief overview of the development of the field, discussing some of the reasons behind its emergence and identifying key characteristics. We will then discuss the attractions of such an interdisciplinary field of research and reflect on the challenges facing those working in this area. We will conclude by proposing an agenda to help promote future interdisciplinary research into the psychology of language learning. This article is published as part of a collection on interdisciplinarity.
Investigation on emission characteristics of metal-ceramic cathode applied to industrial X-ray diode
Authors: Xun Ma , Jianqiang Yuan , Hongwei Liu , Hongtao Li , Lingyun Wang , Ping Jiang
Published: June 2016

The industrial x-ray diode with high impedance configuration is usually adopted to generate repetitive x-ray, but its performance would be worsened due to lower electric field on the cathode of diode when a voltage of several hundreds of kV is applied. To improve its performance, a novel metal-ceramic cathode is proposed in this paper. Key factors (width, relative permittivity of ceramic, and so on) affecting electric field distribution on triple points are analyzed by electrostatic field calculation program, so as to optimize the design of this novel cathode. Experiments are done to study the characteristics including emission current of cathode, diode voltage duration, diode mean dynamic impedance, and diode impedance drop velocity within diode power duration. The results show that metal-ceramic cathode could improve diode performance by enhancing emission current and stabling impedance; the impedance drop velocity of diode with spoke-shaped metal-ceramic cathode was reduced to −5 Ω ns−1 within diode power duration, comparing to −15 Ω ns−1 with metal foil cathode.