bluuebunny/crossref_metadata_2025 huggingface dataset:
Novel Estimations of Hadamard-Type Integral Inequalities for Raina’s Fractional Operators
Authors: Coşkun Merve , Yildiz Çetin , Cotîrlă Luminiţa-Ioana
Published: May 2024

In the present paper, utilizing a wide class of fractional integral operators (namely the Raina fractional operator), we develop novel fractional integral inequalities of the Hermite–Hadamard type. With the help of the well-known Riemann–Liouville fractional operators, s-type convex functions are derived using the important results. We also note that some of the conclusions of this study are more reasonable than those found under certain specific conditions, e.g., s=1, λ=α, σ(0)=1, and w=0. In conclusion, the methodology described in this article is expected to stimulate further research in this area.
ALMA Band 3 Source Counts: A Machine Learning Approach to Contamination Mitigation below 5 Sigma
Authors: Baronchelli Ivano , Bonato Matteo , De Zotti Gianfranco , Casasola Viviana , Delli Veneri Michele , Guglielmetti Fabrizia , Liuzzo Elisabetta , Paladino Rosita , Trobbiani Leonardo , Zwaan Martin
Published: May 2024

We performed differential number counts down to 4.25 sigma using ALMA Band 3 calibrator images, which are known for their high dynamic range and susceptibility to various types of contamination. Estimating the fraction of contaminants is an intricate process due to correlated non-Gaussian noise, and it is often compounded by the presence of false positives generated during the cleaning phase. In addition, calibrator extensions further complicate the counting of background sources. In order to address these challenges, our strategy employs a machine learning-based approach utilizing the UMLAUT algorithm. UMLAUT assigns a value to each detection, and it considers how likely it is for there to be a genuine background source or a contaminant. With respect to this goal, we provide UMLAUT with eight observational input parameters, each automatically weighted using a gradient descent method. Our methodology significantly improves the precision of differential number counts, thus surpassing conventional techniques, including visual inspection. This study contributes to a better understanding of radio sources, particularly in the challenging sub-5 sigma regime, within the complex context of a high dynamic range of ALMA calibrator images.
Incorporation of Resveratrol-Hydroxypropyl-β-Cyclodextrin Complexes into Hydrogel Formulation for Wound Treatment
Authors: Radeva Lyubomira , Yordanov Yordan , Spassova Ivanka , Kovacheva Daniela , Tibi Ivanka Pencheva-El , Zaharieva Maya M. , Kaleva Mila , Najdenski Hristo , Petrov Petar D. , Tzankova Virginia , Yoncheva Krassimira
Published: May 2024

Resveratrol could be applied in wound healing therapies because of its antioxidant, anti-inflammatory and antibacterial effects. However, the main limitation of resveratrol is its low aqueous solubility. In this study, resveratrol was included in hydroxypropyl-β-cyclodextrin complexes and further formulated in Pluronic F-127 hydrogels for wound treatment therapy. IR-spectroscopy and XRD analysis confirmed the successful incorporation of resveratrol into complexes. The wound-healing ability of these complexes was estimated by a scratch assay on fibroblasts, which showed a tendency for improvement of the effect of resveratrol after complexation. The antimicrobial activity of resveratrol in aqueous dispersion and in the complexes was evaluated on methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli, and Candida albicans strains. The results revealed a twofold decrease in the MIC and stronger inhibition of the metabolic activity of MRSA after treatment with resveratrol in the complexes compared to the suspended drug. Furthermore, the complexes were included in Pluronic hydrogel, which provided efficient drug release and appropriate viscoelastic properties. The formulated hydrogel showed excellent biocompatibility which was confirmed via skin irritation test on rabbits. In conclusion, Pluronic hydrogel containing resveratrol included in hydroxypropyl-β-cyclodextrin complexes is a promising topical formulation for further studies directed at wound therapy.
Adoption in the Era of Secrecy: Practical and Ethical Challenges Facing Adult Adoptees in the Search for Birth Families
Authors: Robinson Patricia
Published: May 2024

This article explores findings from research into the impact of adoption throughout the life course of adults who were adopted in the era of secrecy, the 1940s–1970s. A narrative approach was used to explore their reflections, and semi-structured interviews were undertaken with 11 adults. The findings were then analysed through the lens of the Life Course Perspective. Previous studies on adoption have largely explored the outcomes of searching for birth family members, but few have focused on how adoptees went about this, the challenges they encountered, the decisions made and what happened as they began to dismantle layers of secrecy surrounding their adoption. For most of the participants, resources such as genealogical websites and particular guidance were not available at the time they were searching for birth information or attempting to make contact with birth families. Their accounts highlighted how social workers with potential birth information did not appear to be able to consider the broader emotional impact this might entail for adoptees. Initial meetings were described by some adoptees as hurdles to be overcome, and little birth information was given. Some continued to search for birth relatives without support, using random methods to gain contact. The ways in which adults went about their search sometimes appeared to suggest a lack of consideration or awareness on their part of the possible impact on others involved. In reality, they were faced with obstacles and barriers as they attempted to learn about their origins. Their stories provide a valuable insight into how adult adoptees sought to dismantle layers of secrecy, highlighting the complex, challenging and isolated situation they found themselves in as they searched for birth information and birth families, as well as the ethical challenges and dilemmas they had to negotiate in order to do so.
Comparison of Financial Hardship and Healthcare Utilizations Associated with Cancer in the United States Medicare Programs during the COVID-19 Pandemic
Authors: Hu Jiamin , Khan Mishal , Chen Xiaobei , Revere Lee , Hong Young-Rock
Published: May 2024

Background: In the United States, Medicare beneficiaries diagnosed with cancer often face significant financial challenges due to the expensive nature of cancer treatments and increased cost-sharing responsibilities. However, there is limited knowledge regarding the financial hardships and healthcare utilizations faced by those enrolled in Medicare Advantage (MA) compared to those in traditional fee-for-service Medicare (TM) during the COVID-19 pandemic. Our study aims to investigate the subjective financial hardships experienced by individuals enrolled in TM and MA and to determine whether these two Medicare programs exhibit differences in healthcare utilization during the pandemic. Methods: We utilized data from the 2020–2022 National Health Interview Survey (NHIS), focusing on nationally representative samples of cancer survivors aged 65 or older. Financial hardship was categorized into three distinct groups: material (e.g., problems with medical bills), psychological (e.g., worry about paying), and behavioral (e.g., delayed care due to cost). Healthcare utilization included wellness visits (preventive care), emergency care services, hospitalizations, and telehealth. We used survey design-adjusted analysis to compare the study outcomes between MA and TM. Results: Among a weighted sample of 4.4 million Medicare beneficiaries with cancer (mean age: 74.9), 76% were enrolled in MA plans. Cancer survivors with a college degree (59.3% vs. 49.8%) and high family income (38.2% vs. 31.1%) were more likely to enroll in MA plans. There were no significant differences in any material, psychological, or behavioral financial hardship domains between beneficiaries with MA and TM plans except forgone counseling due to cost. For healthcare utilization measures, cancer survivors in MA were more likely than those in TM to have flu vaccination (77.2% vs. 70.1%) and experience lower hospitalizations (16.0% vs. 20.0%). However, there were no differences in other health service utilizations between MA and TM. Conclusion: While no significant differences were observed in any materialized, psychological, or behavioral financial hardships, older cancer survivors enrolled in MA plans were more likely to receive vaccinations and lower hospitalization rates during COVID-19. Although other preventive or primary care visits (i.e., wellness visits) were higher, their difference did not reach statistical significance. As MA grows in popularity, it is essential to consistently monitor and evaluate the performance and outcomes of Medicare plans for cancer survivors as we navigate the post-pandemic landscape.
Engineering Gut Symbionts: A Way to Promote Bee Growth?
Authors: Sattayawat Pachara , Inwongwan Sahutchai , Noirungsee Nuttapol , Li Jilian , Guo Jun , Disayathanoowat Terd
Published: May 2024

Bees play a crucial role as pollinators, contributing significantly to ecosystems. However, the honeybee population faces challenges such as global warming, pesticide use, and pathogenic microorganisms. Promoting bee growth using several approaches is therefore crucial for maintaining their roles. To this end, the bacterial microbiota is well-known for its native role in supporting bee growth in several respects. Maximizing the capabilities of these microorganisms holds the theoretical potential to promote the growth of bees. Recent advancements have made it feasible to achieve this enhancement through the application of genetic engineering. In this review, we present the roles of gut symbionts in promoting bee growth and collectively summarize the engineering approaches that would be needed for future applications. Particularly, as the engineering of bee gut symbionts has not been advanced, the dominant gut symbiotic bacteria Snodgrassella alvi and Gilliamella apicola are the main focus of the paper, along with other dominant species. Moreover, we propose engineering strategies that will allow for the improvement in bee growth with listed gene targets for modification to further encourage the use of engineered gut symbionts to promote bee growth.
A New Species of Scymnus (Coleoptera, Coccinellidae) from Pakistan with Mitochondrial Genome and Its Phylogenetic Implications
Authors: Iqbal Zafar , Azad Rashid , Chen Xiao-Sheng , Lin Xiao-Ling , Zhou Zichen , Wang Xing-Min , Nie Rui-E
Published: May 2024

In this study, a new species of the subgenus Pullus belonging to the Scymnus genus from Pakistan, Scymnus (Pullus) cardi sp. nov., was described and illustrated, with information on its distribution, host plants, and prey. Additionally, the completed mitochondrial genome (mitogenome) of the new species using high-throughput sequencing technology was obtained. The genome contains the typical 37 genes (13 protein-coding genes, two ribosomal RNAs, and 22 transfer RNAs) and a non-coding control region, and is arranged in the same order as that of the putative ancestor of beetles. The AT content of the mitogenome is approximately 85.1%, with AT skew and GC skew of 0.05 and −0.43, respectively. The calculated values of relative synonymous codon usage (RSCU) determine that the codon UUA (L) has the highest frequency. Furthermore, we explored the phylogenetic relationship among 59 representatives of the Coccinellidae using Bayesian inference and maximum likelihood methods, the results of which strongly support the monophyly of Coccinellinae. The phylogenetic results positioned Scymnus (Pullus) cardi in a well-supported clade with Scymnus (Pullus) loewii and Scymnus (Pullus) rubricaudus within the genus Scymnus and the tribe Scymnini. The mitochondrial sequence of S. (P.) cardi will contribute to the mitochondrial genome database and provide helpful information for the identification and phylogeny of Coccinellidae.
H3K27-Altered Diffuse Glioma of the Spinal Cord in Adult Patients: A Qualitative Systematic Review and Peculiarity of Radiological Findings
Authors: Auricchio Anna Maria , Pennisi Giovanni , Menna Grazia , Olivi Alessandro , Gessi Marco , Gielen Gerrit H. , Gaudino Simona , Montano Nicola , Papacci Fabio
Published: May 2024

Background: Primary spinal cord diffuse gliomas (SpDG) are rare tumors that may harbor, like diffuse intrinsic pontine gliomas (DIPG), H3K27M mutations. According to the WHO (2021), SpDGs are included in diffuse midline H3K27-altered gliomas, which occur more frequently in adults and show unusual clinical presentation, neuroradiological features, and clinical behavior, which differ from H3 G34-mutant diffuse hemispheric glioma. Currently, homogeneous adult-only case series of SpDG, with complete data and adequate follow-up, are still lacking. Methods: We conducted a qualitative systematic review, focusing exclusively on adult and young adult patients, encompassing all studies reporting cases of primitive, non-metastatic SpDG with H3K27 mutation. We analyzed the type of treatment administered, survival, follow-up duration, and outcomes. Results: We identified 30 eligible articles published between 1990 and 2023, which collectively reported on 62 adult and young adult patients with primitive SpDG. Postoperative outcomes were assessed based on the duration of follow-up, with outcomes categorized as either survival or mortality. Patients who underwent surgery were followed up for a mean duration of 17.37 months, while those who underwent biopsy had a mean follow-up period of 14.65 months. Among patients who were still alive, the mean follow-up duration was 18.77 months. The radiological presentation of SpDG varies widely, indicating its lack of uniformity. Conclusion: Therefore, we presented a descriptive scenario where SpDG was initially suspected to be a meningioma, but was later revealed to be a malignant SpDG with H3K27M mutation.
Incidence of Thrombosis in COVID-19 Patients Compared to Non-COVID-19 Sepsis Patients in the Intensive Care Unit
Authors: Huang Sherri , Perry Ashley , Sanchez Parra Carlos , Gonzalez Torriente Adriana , Ghumman Haider , Charkowick Shaun , Colon Joshua , Heide McKenzi , Jaglal Michael , Mhaskar Rahul , Rico Juan Felipe
Published: May 2024

Background/Objectives: The hypercoagulable state associated with COVID-19 infection is associated with adverse outcomes and mortality. Studies have also demonstrated high rates of venous thromboembolism (VTE) events among patients with sepsis. We aimed to evaluate how the increase in thrombotic events in critically ill patients with COVID-19 infection compares to that of critically ill patients with non-COVID-19 sepsis. Methods: A chart review was performed of patients 18 years or older admitted to the intensive care unit (ICU) at Tampa General Hospital between 1 January 2020 and 31 December 2020 diagnosed with COVID-19 or sepsis secondary to other pathogens. Non-COVID-19 sepsis patients and COVID-19 patients were propensity-matched 3:1 on the Charlson Comorbidity Index. Multivariate analyses adjusting for confounding were conducted to report odds ratio (OR) and 95% confidence intervals (95% CIs) of predictors for thrombotic events and overall mortality. Results: After propensity score matching, 492 sepsis patients and 164 COVID-19 patients were included in the analysis. COVID-19 patients were significantly older (p = 0.021) and showed higher BMI (p < 0.001) than sepsis patients. COVID-19 patients did not show significantly higher odds of thrombosis after adjustment for confounders (OR 0.85, 95% CI 0.42–1.72), but had significantly lower odds of mortality than sepsis patients (OR 0.33, 95% CI 0.16–0.66). Conclusions: Our results suggest that further study is required to lower the rate of VTE in COVID-19 and non-COVID-19 sepsis patients admitted to the ICU; it is also reasonable to consider similar thromboembolism practices between these two patient groups.
Interscapular Pain after Anterior Cervical Discectomy and Fusion: Does Zygapophyseal Joints over Distraction Play a Role?
Authors: Ricciardi Luca , Bongetta Daniele , Piazza Amedeo , Norri Nicolò , Mangraviti Antonella , Trungu Sokol , Belli Evaristo , Zanin Luca , Lofrese Giorgio
Published: May 2024

Introduction: Anterior cervical discectomy and fusion (ACDF) for cervical disc herniation (CDH) is commonly performed. Specific post-operative complications include dysphagia, dysphonia, cervicalgia, adjacent segment disorder, cage subsidence, and infections. However, interscapular pain is commonly reported by these patients after surgery, although its mechanisms have not been clarified yet. Methods: This retrospective series of 31 patients undergoing ACDF for CDH at a single Academic Hospital. Baseline and post-operative clinical, radiological, and surgical data were analyzed. The linear regression analysis was conducted to identify any factor independently influencing the incidence rate of post-operative interscapular pain. Results: The mean age was 57.6 ± 10.8 years, and the M:F ratio was 2.1. Pre-operative mean VAS-arm was 7.15 ± 0.81 among the 20 patients reporting brachialgia, and mean VAS-neck was 4.36 ± 1.43 among those 9 patients reporting cervicalgia. At 1 month, interscapular pain was still reported by 8 out of the 17 patients who experienced it post-operatively, and it was recovered in all patients after 2 months. The regression analysis showed that interscapular pain was not directly associated with age (p = 0.74), gender (p = 0.46), smoking status (p = 0.44), diabetes (0.42), pre-operative brachialgia (p = 0.21) or cervicalgia (p = 0.48), symptoms duration (p = 0.13), baseline VAS-arm (p = 0.11), VAS-neck (p = 0.93), or mJOA (p = 0.63) scores, or disc height modification (p = 0.90). However, the post-operative increase in the mean zygapophyseal joint rim distance was identified as an independent factor in determining interscapular pain (p = 0.02). Conclusions: Our study revealed that the onset of interscapular pain following ACDF may be determined by over distraction of the zygapophyseal joint rim. Then, proper sizing of prosthetic implants could reduce this painful complication.
Microvascular Density Analysis of Patients with Inactive Systemic Lupus Erythematosus—A Two-Year Follow-Up Optical Coherence Tomography Angiography Study
Authors: Leclaire Martin Dominik , Esser Eliane Luisa , Dierse Sebastian , Koch Raphael , Zimmermann Julian Alexander , Storp Jens Julian , Gunnemann Marie-Louise , Lahme Larissa , Eter Nicole , Mihailovic Nataša
Published: May 2024

Background/Objectives: This study aims to investigate the long-term effect of inactive systemic lupus erythematosus (SLE) on the retinal microcirculation measured via optical coherence tomography angiography (OCT-A). Methods: Twenty-four eyes of 24 patients with inactive SLE under hydroxychloroquine (HCQ) therapy were included. The OCT-A data (mainly vessel density (VD) and foveal avascular zone (FAZ) data of the superficial and of the deep capillary plexus (SCP, DCP) and the choriocapillaris (CC)) were analyzed and compared between the baseline examination (t0) and 2 years later (t1). Results: At t1, VD in the whole en face SCP and in the CC was notably reduced compared to t0 (SCP: p = 0.001, CC: p = 0.013). VD in the DCP, CRT and FAZ area showed no difference at t1 compared to t0 (DCP: p = 0.128, FAZ: p = 0.332, CRT fovea: p = 0.296). Correlation analysis between the increase in cumulative doses of HCQ between t0 and t1 and the VD of the whole en face SCP did not show any correlation (Spearman r = 0.062 (95% CI −0.367; 0.477). Conclusions: SLE patients demonstrated a decrease in the retinal VD of the SCP and CC over a 2-year period. There was no correlation with the change in cumulative doses of HCQ. These results suggest an ongoing effect of the disease on the retinal and choriocapillary microcirculation.
Can the Pathological Response in Patients with Locally Advanced Gastric Cancer Receiving Neoadjuvant Treatment Be Predicted by the CEA/Albumin and CRP/Albumin Ratios?
Authors: Bayram Ertugrul , Kidi Mehmet Mutlu , Camadan Yasemin Aydınalp , Biter Sedat , Yaslikaya Sendag , Toyran Tugba , Mete Burak , Kara Ismail Oguz , Sahin Berksoy
Published: May 2024

Background: The purposes of neoadjuvant chemotherapy are to tumor size to improve the tumor removal rate, extend survival, and prevent metastasis. In this study, the importance of CRP/albumin ratio and CEA/albumin ratio in the prediction of neoadjuvant treatment response in gastric cancer patients was evaluated. Methods: This study retrospectively included 135 gastric cancer patients who received neoadjuvant chemotherapy at Çukurova University Balcalı Hospital between January 2018 and December 2023. Preoperative CRP/albumin and CEA/albumin ratios were compared according to treatment response and multivariate logistic regression analysis was performed to determine the potential importance of these ratios in predicting pathological response. Results: The mean age of the 135 patients was 58.79 ± 10.83 (min = 26–max = 78). The CRP/albumin and CEA/albumin ratios were found to be significantly lower in patients who did not respond to neoadjuvant therapy. Each 1-unit increase in the CRP/albumin ratio was associated with a 1.16-fold decrease in the odds of pathological complete response to neoadjuvant therapy. Both CRP/albumin and CEA/albumin ratios were found to be significant in distinguishing neoadjuvant therapy response. The optimal cut-off value was 2.74 for the CRP/albumin ratio (sensitivity = 60%, specificity = 78.4%) and 1.40 for the CEA/albumin ratio (sensitivity = 74.2%, specificity = 67.6%). Values below these cut-off points favored neoadjuvant therapy response. Pathological complete response to neoadjuvant therapy was 4.75 times higher in patients with a CRP/albumin ratio below 2.74 and 5.14 times higher in patients with a CEA/albumin ratio below 1.40. Conclusions: Findings demonstrate that in patients with locally advanced gastric cancer receiving neoadjuvant treatment, CRP/Albumin and CEA/Albumin ratios are significant markers of pathological response.
Ultraviolet Filters: Dissecting Current Facts and Myths
Authors: Breakell Thomas , Kowalski Isabel , Foerster Yannick , Kramer Rafaela , Erdmann Michael , Berking Carola , Heppt Markus V.
Published: May 2024

Skin cancer is a global and increasingly prevalent issue, causing significant individual and economic damage. UV filters in sunscreens play a major role in mitigating the risks that solar ultraviolet ra-diation poses to the human organism. While empirically effective, multiple adverse effects of these compounds are discussed in the media and in scientific research. UV filters are blamed for the dis-ruption of endocrine processes and vitamin D synthesis, damaging effects on the environment, induction of acne and neurotoxic and carcinogenic effects. Some of these allegations are based on scientific facts while others are simply arbitrary. This is especially dangerous considering the risks of exposing unprotected skin to the sun. In summary, UV filters approved by the respective governing bodies are safe for human use and their proven skin cancer-preventing properties make them in-dispensable for sensible sun protection habits. Nonetheless, compounds like octocrylene and ben-zophenone-3 that are linked to the harming of marine ecosystems could be omitted from skin care regimens in favor of the myriad of non-toxic UV filters.
Evolocumab Treatment in Dyslipidemic Patients Undergoing Coronary Artery Bypass Grafting: One-Year Safety and Efficacy Results
Authors: Nasso Giuseppe , Vignaroli Walter , Amodeo Vincenzo , Bartolomucci Francesco , Larosa Claudio , Contegiacomo Gaetano , Demola Maria Antonietta , Girasoli Cataldo , Valenzano Antongiulio , Fiore Flavio , Bonifazi Raffaele , Triggiani Vera , Vitobello Vincenza , Errico Giacomo , Lamanna Angela , Hila Dritan , Loizzo Tommaso , Franchino Rosalba , Sechi Stefano , Valenti Giovanni , Diaferia Giuseppe , Brigiani Mario Siro , Arima Serena , Angelelli Mario , Curcio Antonio , Greco Francesco , Greco Ernesto , Speziale Giuseppe , Santarpino Giuseppe
Published: May 2024

Background: The inhibition of PCSK9 lowered LDL cholesterol levels, reducing the risk of cardiovascular events. However, the effect on patients who have undergone surgical myocardial revascularization has not yet been evaluated. Methods: From January 2017 to December 2022, 180 dyslipidemic patients who underwent coronary artery bypass were included in the study. Until December 2019, 100 patients optimized therapy with statin ± ezetimibe (SG). Since January 2020, 80 matched patients added treatment with Evolocumab every 2 weeks (EG). All 180 patients were followed-up at 3 and 12 months, comparing outcomes. Results: The two groups are homogenous. At 3 months and 1 year, a significant decrease in the parameter mean levels of LDL cholesterol and total cholesterol is detected in the Evolocumab group compared to the standard group. No mortality was detected in either group. No complications or drug discontinuation were recorded. In the SG group, five patients (5%) suffered a myocardial infarction during the 1-year follow-up. In the EG group, two patients (2.5%) underwent PTCA due to myocardial infarction. There is no significant difference in overall survival according to the new treatment (p-value = 0.9), and the hazard ratio is equal to 0.94 (95% C.I.: [0.16–5.43]; p-value = 0.9397). Conclusions: The use of Evolocumab, which was started immediately after coronary artery bypass graft surgery, significantly reduced LDL cholesterol and total cholesterol levels compared to statin treatment alone and is completely safe. However, at one year of follow-up, this result did not have impact on the reduction in major clinical events.
Betting on Your Feelings: The Interplay between Emotion and Cognition in Gambling Affective Task
Authors: Mari Emanuela , Cricenti Clarissa , Boccia Maddalena , Zucchelli Micaela Maria , Nori Raffaella , Piccardi Laura , Giannini Anna Maria , Quaglieri Alessandro
Published: May 2024

Background: Gambling Disorder (GD) is a bio-psycho-social disorder resulting from the interaction of clinical, cognitive, and affective factors. Impulsivity is a crucial factor in addiction studies, as it is closely linked to cognitive distortions in GD by encompassing impulsive choices, motor responses, decision-making, and cognitive biases. Also, emotions, mood, temperament, and affective state are crucial in developing and maintaining GD. Gambling can be used as a maladaptive coping strategy to avoid or escape problems and distress. Methods: The aim of the present study is to explore differences in personality traits and emotion regulation of people suffering from GD, substance-dependent gamblers (SDGs), and healthy controls (HCs). Additionally, the study proposes a new experimental task: the “Gambling Affective Task” (GAT) to investigate the influence of affective priming on risk-taking behaviors. Results: Our findings indicate that participants placed lower bets following positive priming. Additionally, SDGs wagered significantly higher amounts than HCs, regardless of priming type. In general, participants exhibited longer response times after positive priming trials, compared to negative and neutral priming trials. These findings suggest that experiencing positive emotions can act as a protective factor by delaying and lengthening gambling behaviors. By comparing gamblers with and without substance comorbidity, we can gain insight into the exclusive factors of GD and improve our understanding of this disorder. Conclusions: By elucidating the impact of emotional states on risk-taking, the research also provides new insights into the prevention and treatment of GD.
Combined Brain–Heart Imaging in Takotsubo Syndrome: Towards a Holistic Patient Assessment
Authors: Markousis-Mavrogenis George , Pepe Alessia , Bacopoulou Flora , Lupi Amalia , Quaia Emilio , Chrousos George P. , Mavrogeni Sophie I.
Published: May 2024

Takotsubo syndrome (TTS) is a type of cardiomyopathy usually precipitated by either emotional or physical stress and potentially leading to reversible heart failure. There is emerging evidence indicating an interaction between the brain and the heart in patients with TTS. Nevertheless, these new insights are not reflected in the current clinical approach to TTS. The application of novel and existing imaging modalities for the evaluation of brain–heart interactions is an interesting approach that could potentially augment diagnostic and prognostic yield, as well as improve our pathophysiologic understanding in the context of TTS. In this opinion piece, we discuss the evidence supporting a brain–heart interaction in patients with TTS and discuss how a combined evaluation of brain–heart interactions could potentially be implemented.
Incidence Rates of Infections in Rheumatoid Arthritis Patients Treated with Janus Kinase or Interleukin-6 Inhibitors: Results of a Retrospective, Multicenter Cohort Study
Authors: Yoshida Shuhei , Miyata Masayuki , Suzuki Eiji , Kanno Takashi , Sumichika Yuya , Saito Kenji , Matsumoto Haruki , Temmoku Jumpei , Fujita Yuya , Matsuoka Naoki , Asano Tomoyuki , Sato Shuzo , Migita Kiyoshi
Published: May 2024

Objective: This study aimed to compare the incidence rates (IRs) of infections, including herpes zoster (HZ), in rheumatoid arthritis (RA) patients treated with Janus kinase inhibitors (JAKis) or interleukin-6 inhibitors (IL-6is). Methods: We retrospectively analyzed 444 RA patients treated using IL-6is (n = 283) or JAKis (n = 161). After adjusting for clinical characteristic imbalances by propensity score matching (PSM), we compared the IRs of infections including HZ between the JAKi and IL-6i groups. Results: Observational period: 1423.93 patient years (PY); median observational period: 2.51 years. After PSM, incidence rate ratios comparing JAKi with IL-6i were 3.45 (95% confidence interval [CI]: 1.48–9.04) for serious infections other than HZ indicating that the JAKi-treated group was more likely to develop serious infection than the IL-6i-treated group. Multivariate Cox regression analyses revealed that the use of prednisolone > 5.0 mg/day, coexisting interstitial lung disease (ILD), and diabetes mellitus (DM) were independent risk factors for serious infections. The crude IR for HZ was significantly higher in the JAKi group, but the difference between groups was not significant (IRR: 2.83, 95% CI: 0.87–10.96) in PSM analysis. Unadjusted and PSM analyses performed in our study showed increased IRs of serious infections in patients with RA treated with JAKis compared with those treated with IL-6is. Conclusions: The presence of ILD or DM and the use of prednisolone were found to be independent risk factors for serious infection in RA patients treated using JAKis. Whereas the IRs for HZ after PSM were not significantly different between the JAKi and IL-6i groups.
Trochleoplasty Provides Good Outcomes for Recurrent Patellofemoral Dislocations with No Clear Superiority across Different Techniques
Authors: Tan Sharon Si Heng , Law Gin Way , Kim Sunny Sunwoo , Sethi Ervin , Lim Andrew Kean Seng , Hui James Hoi Po
Published: May 2024

Background: Literature is sparse on outcome comparisons between different trochleoplasty techniques in the treatment of patella instability. To date, it is unclear whether there is a technique that offers superior outcomes. This systematic review and meta-analysis aims to compare and evaluate the outcomes of trochleoplasty techniques in the treatment of patellofemoral instability in trochlea dysplasia to establish whether there is an ideal choice of trochleoplasty technique for superior outcomes. Methods: 21 studies involving 880 knees were included. The mean age of the patients was 21.7 years (range 8–49 years). Mean follow-up timeframe of 43.5 months (range 8.8–100 months). Clinical outcomes assessed included rates of recurrence of patellofemoral dislocation, patient satisfaction, Kujala score, International Knee Documentation Committee (IKDC) score, Tegner score, and Lysholm score. Egger’s test showed no publication bias across all outcomes assessed. Results: Favourable results were seen across all outcomes assessed and patient satisfaction. Improvements were seen with Kujala, IKDC, and Lysholm scores. Tegner scores showed good return to function. Post-operative dislocation and complication rates were low across the different techniques. Meta-regression for Kujala and IKDC scores showed good outcomes regardless of trochleoplasty technique used (Kujala, p = 0.549, relative risk 492.06; IKDC, p = 0.193, RR 0.001). The exact risk that trochleoplasty poses to the cartilage remains uncertain, as no study had a conservatively managed arm for comparison. Conclusions: Trochleoplasty yielded good outcomes irrespective of technique used with no clear superiority demonstrated in any technique in terms of outcome scores, satisfaction, post-operative dislocation rates or complications.
Unlocking the Long-Term Effectiveness of Benralizumab in Severe Eosinophilic Asthma: A Three-Year Real-Life Study
Authors: Pini Laura , Bagnasco Diego , Beghè Bianca , Braido Fulvio , Cameli Paolo , Caminati Marco , Caruso Cristiano , Crimi Claudia , Guarnieri Gabriella , Latorre Manuela , Menzella Francesco , Micheletto Claudio , Vianello Andrea , Visca Dina , Bondi Benedetta , El Masri Yehia , Giordani Jordan , Mastrototaro Andrea , Maule Matteo , Pini Alessandro , Piras Stefano , Zappa Martina , Senna Gianenrico , Spanevello Antonio , Paggiaro Pierluigi , Blasi Francesco , Canonica Giorgio Walter ,   on behalf of the SANI Study Group
Published: May 2024

Background: Benralizumab has been shown to restore good control of severe eosinophilic asthma (SEA). Robust data on benralizumab effectiveness over periods longer than 2 years are scarce. Methods: This retrospective multicentric study was conducted on 108 Italian SEA patients treated with benralizumab for up to 36 months. Partial and complete clinical remission (CR) were assessed. Data were analyzed with descriptive statistics or using linear, logistic, and negative binomial mixed-effect regression models. Results: At 36 months, benralizumab reduced the exacerbation rate by 89% and increased the forced expiratory volume in 1 second (FEV1) (+440 mL at 36 months, p < 0.0001). Benralizumab improved asthma control as well as sinonasal symptoms in patients with chronic rhinosinusitis with nasal polyposis (CRSwNP). Up to 93.33% of patients either reduced or discontinued OCS; benralizumab also decreased ICS use and other asthma medications. Overall, 84.31% of patients achieved partial or complete CR. Conclusions: Benralizumab improved asthma and sinonasal outcomes up to 36 months. These findings support the potential of benralizumab to induce CR, emphasizing its role as a disease-modifying anti-asthmatic drug for the management of SEA. Further research is warranted to expand these findings by minimizing data loss and assessing benralizumab’s long-term safety.
Environmental Justice in the Context of Access to Urban Green Spaces for Refugee Children
Authors: Chen Siqi , Knöll Martin
Published: May 2024

Accessible and high-quality urban green space (UGS) can provide significant benefits to refugee children for their development, health, and well-being. However, few studies have examined the actual accessibility of UGS from refugee children’s perspectives (i.e., with restricted walking radius, particular vulnerability towards barriers such as traffic infrastructures and disconnected road forms) and related them with other environmental or social burdens under the context of environmental justice. It is necessary to explore related evidence and investigate the underlying causes since refugee facilities are primarily located in areas with restricted social and environmental resources strongly related to attributes of environmental justice. This paper investigated (1) availability, accessibility, and attractiveness of UGS in 30 refugee accommodation locations in Berlin using GIS and Space Syntax, (2) environmental burdens using the Berlin Atlas of Environmental Justice, and (3) neighbourhood characteristics. Findings indicate that 63% of refugee accommodations have availability of green space that is above average official standards, but from refugee children’s perspectives, 60% of the locations have limited access to UGS, lower attractive green spaces, and most locations face multi-environmental burdens. Currently, little guidance focuses on ensuring equal access to and the usability of UGS for specific socioeconomic and demographic groups, such as refugee children. Therefore, this paper has contributed empirical materials to begin such research and develop inclusive decision-making strategies in environmental and health policy to ensure the provision and high quality of UGS for refugee children who need it.
Transformation of the Saudi Housing Sector through an Enabling Approach to Affordable Housing
Authors: Alhajri Mubarak F.
Published: May 2024

Access to affordable housing has a significant impact on the quality of lives of households and the overall well-being of communities. The enabling approach is recognized internationally as a mechanism for housing delivery, shifting the government’s role from that of a direct provider to that of an enabler within housing markets. In line with its Vision 2030, Saudi Arabia aims to transition its role from a direct housing provider to an enabler. This study aimed to assess the extent to which enabling strategies have been implemented within the Saudi Arabian context. This research was conducted based on a desktop study of the key literature, analysis of secondary data, and content analysis of the collected documents to address the research aim. The study found that housing costs, traditional land tenure, and insufficient financing are major housing challenges, intensified by high lending interest, lack of investor diversity in housing types, and lack of long-term funding from financiers. Also, slum developments are limited to providing street access, without addressing the overall conditions and the level of services. In addition, the costs of obtaining permits and implementing building regulations have contributed to housing shortages in the country. On the other hand, real estate developers of different scales undergo a classification and qualification system to increase their capacity for housing supply. To address these challenges, the Saudi government has implemented an enabling approach, serving as a provider for low-income and vulnerable groups through the Developmental Housing Program. The government also encourages local manufacturing of building materials to boost the construction industry. The present study recommends that the government enhance existing instruments to enable access to affordable housing.
Evaluation of Cognitive Performance in Patients with Fibromyalgia Syndrome: A Case–Control Study
Authors: Fernández-Palacios Francisco G. , Pacho-Hernández Juan C. , Fernández-de-las-Peñas César , Gómez-Calero Cristina , Cigarán-Méndez Margarita
Published: May 2024

Patients with fibromyalgia syndrome tend to report deficits in cognitive functions; however, there is no clear consensus on which cognitive domains are impaired. The aim of this study was to compare the differences in cognitive performance between a group of patients with fibromyalgia syndrome and a group of pain-free subjects controlling for the covariables anxiety, depression, and sleep quality. In total, 130 patients with fibromyalgia syndrome and 111 pain-free subjects with an average age of 54.96 years completed the evaluation protocol consisting of sociodemographic data, psychological data, and neurocognitive tests. All data were collected from May 2022 to May 2023. Multivariate analyses of covariance (MANCOVAs) were conducted to assess intergroup differences in all neurocognitive tests. MANCOVA analyses showed that the group of patients with fibromyalgia showed a worse cognitive performance than the group of pain-free subjects after controlling for anxiety, depression, and sleep quality. This study found that fibromyalgia patients exhibited worse cognitive performance and executive function than pain-free subjects. Thus, cognitive performance seems to not be related with anxiety, depression, or sleep quality in our sample of women with FMS.
A Stochastic Semi-Parametric SEIR Model with Infectivity in an Incubation Period
Authors: Zhang Jing , Jin Tong
Published: May 2024

This paper introduces stochastic disturbances into a semi-parametric SEIR model with infectivity in an incubation period. The model combines the randomness of disease transmission and the nonlinearity of transmission rate, providing a flexible framework for more accurate description of the process of infectious disease transmission. On the basis of the discussion of the deterministic model, the stochastic semi-parametric SEIR model is studied. Firstly, we use Lyapunov analysis to prove the existence and uniqueness of global positive solutions for the model. Secondly, the conditions for disease extinction are established, and appropriate stochastic Lyapunov functions are constructed to discuss the asymptotic behavior of the model’s solution at the disease-free equilibrium point of the deterministic model. Finally, the specific transmission functions are enumerated, and the accuracy of the results are demonstrated through numerical simulations.
Persistence and Stochastic Extinction in a Lotka–Volterra Predator–Prey Stochastically Perturbed Model
Authors: Shaikhet Leonid , Korobeinikov Andrei
Published: May 2024

The classical Lotka–Volterra predator–prey model is globally stable and uniformly persistent. However, in real-life biosystems, the extinction of species due to stochastic effects is possible and may occur if the magnitudes of the stochastic effects are large enough. In this paper, we consider the classical Lotka–Volterra predator–prey model under stochastic perturbations. For this model, using an analytical technique based on the direct Lyapunov method and a development of the ideas of R.Z. Khasminskii, we find the precise sufficient conditions for the stochastic extinction of one and both species and, thus, the precise necessary conditions for the stochastic system’s persistence. The stochastic extinction occurs via a process known as the stabilization by noise of the Khasminskii type. Therefore, in order to establish the sufficient conditions for extinction, we found the conditions for this stabilization. The analytical results are illustrated by numerical simulations.
A Methodology for Post-Necking Analysis in Isotropic Metals
Authors: Scapin Martina , Beltramo Marta
Published: May 2024

Metallic materials are commonly characterized through tensile tests. For ductile metals, a consistent part of the test occurs after the necking onset. A first estimate of the post-necking behavior could be obtained by extrapolating the mathematical model that fits the pre-necking law. However, as well known, the accuracy of the predictions would not be guaranteed. Therefore, over the past decades many efforts have been devoted to dealing with the necking phenomenon. The most popular correction formula proposed by Bridgman is an analytical method based on the neck geometry. Despite being widely used, it may not be accurate at large strains due to the assumption of uniform distribution of the equivalent stress and equivalent strain in the specimen minimum cross-section. Starting from Bridgman’s idea and in order to overcome its limitations, the present paper develops an efficient method to calibrate the hardening law of isotropic metallic materials at large strains. The proposed method requires to record the outer contour of the necking zone during the test and to build a dataset of necking deformed shapes. Experimental quasi-static tensile tests were analyzed with the proposed approach, which appears promising when critically compared with other methods.
Heterostructure Engineering Enables MoSe2 with Superior Alkali-Ion Storage
Authors: Kong Huabin , Wen Yihan , Chen Siying , Chen Xiyao , Chen Runzhi , Yan Jiamou , Mao Nianjie
Published: May 2024

Molybdenum diselenide (MoSe2) is a promising anode for alkali-ion storage due to its intrinsic advantages. However, MoSe2 still encounters the issues of structural instability and poor rate performance caused by drastic volume change and sluggish reaction kinetics. Reasonable design of electrode structure is crucial for achieving superior electrochemical performance. Herein, a novel hierarchical structure coupled with 1D/1D subunits is elaborately designed and constructed, in which the MoSe2/CoSe2 heterostructure is the “trunk” and the N-doped carbon nanotubes are the “branches” (MoSe2/CoSe2/NCNTs). Benefiting from the properties endowed by unique configurations, MoSe2/CoSe2/NCNTs electrodes manifest faster reaction kinetics and better structure durability. Evaluated as an anode for LIBs and SIBs, MoSe2/CoSe2/NCNTs deliver high reversible capacity, superior rate capability (452 at 10 A g−1 in LIBs and 296 at 10 A g−1 in SIBs), and prominent cycle life (553 after 2000 cycles at 5 A g−1 in LIBs and 310 after 2000 cycles at 5 A g−1 in SIBs). Such design conception can also provide guidance for the development of other high-performance electrodes.
Batch Sintering of FeO·OH and Fe2O3 Blends: Chemical and Metallurgical Characterization
Authors: Pereira Igor J. U. V. , Coelho Henrique C. S. , Santos Cláudio G. , Brocchi Eduardo A. , Souza Rodrigo F. M. , Oliveira Victor A. A.
Published: May 2024

A sample of goethite iron ore sinter feed (G_SF) was employed as a raw material in a sintering bed. This sample partially replaced hematite sinter feed (H_SF), which is currently used as raw material in a sintering plant in the state of Minas Gerais, Brazil. This substitution did not adversely affect the chemical and metallurgical proprieties of the sinter mix product, provided that the utilization of G_SF was kept below 30% in weight. Despite the higher proportion of fines in G_SF, the presence of argillaceous minerals in the sample led to an improvement in the granulation index (GI) of the sinter mix product. The GI value increased from 68.4 to 82.7% for the experiments conducted without the presence of goethite ore and with 40% of goethite ore in the sintering mix, respectively. Consequently, the qualities of both the process and the produced sinter product were not compromised. The raw materials and the various sinters produced were characterized through X-ray fluorescence (XRF) and X-ray diffraction (XRD), as well as thermal gravimetric analysis (TGA). The XRD results were used to perform a quantitative assessment of the mineral phase using the Rietveld method (RM). This technique allowed for the determination of goethite content in the studied sample, which was 35.5%. Finally, the incorporation of G_SF in the sintering bed led to a 20% reduction in the cost of raw materials.