bluuebunny/crossref_metadata_2025 huggingface dataset:
Coordinated Patient Appointment Scheduling for a Multistation Healthcare Network
Authors: Wang Dongyang , Muthuraman Kumar , Morrice Douglas
Published: May 2019

Outpatient services account for more than four-fifths of patient care in the United States, and most patients access these services via appointment scheduling. Because of the possibility of patient no-shows, healthcare providers usually rely on overbooking. If very few patients show up, it will leave hospital resources underutilized, whereas too many showing up will increase patient wait times and increase staff overtime costs. In a hospital or a network of clinics, where patients could enter and exit at various stations and have complex flow patterns, scheduling becomes even more of a challenge. In “Coordinated Patient Appointment Scheduling for a Multistation Healthcare Network,” D. Wang, K. Muthuraman, and D. Morrice propose a multistation network model that carefully strikes a balance between assumptions that allow tractability and assumptions that disallow real-world adoption. Given the complexity involved in solving the model, they explore a sequence of approximations and find one that offers a significant computational advantage.
Inspiratory muscle training in severe spinal muscular atrophy: a case report
Authors: Human Anri , Honey Engela , Morrow Brenda
Published: May 2019

Background/Aims

Inspiratory muscle training aims to preserve or improve respiratory muscle strength in children with neuromuscular diseases in order to prevent or minimise pulmonary morbidity. The aim of this study was to determine the effect of inspiratory muscle training on clinical outcomes and health-related quality of life in a child with advanced neuromuscular disease and severe pulmonary restriction.

Methods

A one patient pre-test post-test study design was implemented. General function, spirometry, peak expiratory cough flow and health-related quality of life were measured at baseline and after a 6-week inspiratory muscle training programme. Inspiratory muscle strength (maximal inspiratory mouth pressure and sniff nasal inspiratory pressure) was measured every 2 weeks. The patient used a tapered flow threshold inspiratory training device (POWERbreathe K3) at an intensity of ± 30% of maximal inspiratory mouth pressure twice a day, 5 days per week.

Findings

The non-ambulatory 10-year-old girl with type 2 spinal muscular atrophy initially had a forced vital capacity of 18% predicted and peak expiratory cough flow of 60 litres/minute. A substantial improvement was seen in inspiratory muscle strength between baseline and 4 weeks. Patient health-related quality of life improved and patient satisfaction was high, with a score of 9/10. The patient developed a lower respiratory tract infection towards the end of the inspiratory muscle training period. No other adverse events occurred.

Conclusions

Improved inspiratory muscle strength and health-related quality of life was associated with inspiratory muscle training in a child with advanced spinal muscular atrophy. Controlled clinical trials are recommended to determine the safety and efficacy of inspiratory muscle training in children with advanced spinal muscular atrophy and severe respiratory muscle weakness to inform clinical practice.
Occupational performance in mothers of children with cerebral palsy
Authors: Havaei Naser , Rezaei Mandana , Rostami Hamid Reza , Mohammadi Ahmad , Kashefimehr Babak , Mirzaei Mohammad Javad
Published: May 2019

Background/Aims

Caring for children with cerebral palsy may affect different domains in the caregiver's life. This study aimed to compare the occupational performance of mothers of a child who has cerebral palsy with mothers of a typically developing child.

Methods

A total of 41 mothers with a child who has cerebral palsy and 45 mothers with a typically developing child were recruited in this cross-sectional study. The age-matched mothers had only one child. The Canadian Occupational Performance Measure was used to collect data on the occupational performance and satisfaction of mothers.

Findings

There was a statistically significant between-group difference in maternal occupational performance and occupational satisfaction (P<0.05), with mothers of children with cerebral palsy reporting lower scores for both. There were no relationships between demographic variables and the occupational performance and satisfaction of mothers with a child with cerebral palsy (P>0.05). The age of children with cerebral palsy had a direct positive relationship with the mothers' level of occupational satisfaction (P<0.05).

Conclusion

Mothers who take care of a child with cerebral palsy face significant reductions in occupational performance and satisfaction compared to mothers with a typically developing child, and therefore may need help and education in performing and organising their daily activities and roles.
Design briefs in design-driven new product development
Authors: Parkman Ian , Malkewitz Keven
Published: May 2019

This study empirically examines the role of product design briefs as knowledge-based artefacts of cross-functional collaboration within design-driven new product development (NPD). Contemporary NPD is increasingly seen as a design-driven and knowledge-based activity where information sharing within team-based environments is critical to successful product design and development processes. However, the mere presence of inter-functional structures has not necessarily led to better outcomes for firms. By drawing on a proprietary sample of 80 product design briefs gathered from design-driven product-oriented firms, our results provide insight into how organizations create, codify and communicate knowledge from different functional areas and support flows of knowledge within NPD, specifically by: (1) providing an inventory of 51 information elements commonly present in product design briefs; (2) organizing these information elements into a parsimonious framework of strategic dimensions using exploratory factor analysis (EFA) alongside a widely-established taxonomy; (3) defining differences between information elements as rated by managerial ‘importance’ across three key functional areas of NPD: (a) design, (b) marketing and (c) engineering/ R&D/ development; and (4) providing a theoretic rationale for these differences and underlying strategic dimensions by integrating our findings with relevant literature.
Design insights for socially-led interventions
Authors: Phillips Robert
Published: May 2019

Design has become an accessible tool for organizations to create impactful outputs. These topics have diverged from mere retail to include: economic prospects, technological paradigms, social empowerment, sustainable resources, citizen-led opportunities and challenges that cross demographics, societies and cultures. Accessible technologies and the reduction of barriers to pilot funding have (in part) enabled the advancement of these socially-led responses through design. ‘Enablers’ take many forms including: digital manufacturing, accessible hardware, design platforms and smart technologies, all challenging what ‘designed products’ are as the ‘product’ is a social impact or intervention. The work mines embedded knowledge from successful award-winning organizations, which have not publically shared their unique insights. The work analyses an interview series of 60 plus CEOs, founders and co-founders of socially-led organizations with both design and non-design origins. The work identifies socially-led design ‘architectures’, highlighting issues, lessons and transferable insights. The study includes global organizations occupying territories of: not-for-profits, commercial practices, grass roots organizations, science practitioners, community-led ventures and intellectual property enterprises, selected from leading awards. The article identifies insights leading towards ‘socially-led product architecture’, and repeatable lessons, for non-design and design audiences.
A design-led approach to transforming wicked problems into design situations and opportunities
Authors: Bailey Mark , Chatzakis Emmanouil , Spencer Nicholas , Lampitt Adey Kate , Sterling Nate , Smith Neil
Published: May 2019

This article argues that using a design-led approach is highly beneficial when tackling complex problems to transform ambiguity into actionable design briefs and solution opportunities. This is evidenced by way of an ongoing project with a large public-sector organization. Northumbria University’s School of Design academic experts use design-led approaches to innovation that promotes ‘creative fusion’ between diverse stakeholders in order to tackle ‘wicked problems’. The authors continue this work as part of an Arts and Humanities Research Council/ European Regional Development Fund-funded programme entitled Creative Fuse North East (CFNE), involving five regional universities, of which the project discussed here is a part. The main objectives of CFNE are to develop and deploy approaches to innovation that apply skills from creative graduates to benefit the wider creative economy, address barriers to innovation and promote growth and sustainability within and without the Creative, Digital and IT sector (CDIT). The authors propose that to do this it is vital to convert stakeholders into co-creation activists empowered with the creative confidence and tools required to speculate about uncertain futures.
A critical discourse analysis of Saudi Okaz newspaper front-page headlines: A case study
Authors: Elyas Tariq , Al-Zahrani Najwa Ali
Published: May 2019

The present article aims to probe the language used in one Saudi newspaper, Okaz. It investigates the application of the critical discourse analysis on newspaper texts. Special attention was paid to front-page headlines. This study seeks to examine the textual features and the discursive features of Okaz newspaper. To achieve this goal, fourteen prints from Okaz were considered in the analysis. The findings revealed that language is used intelligently in three linguistic aspects: semantics, syntax and lexical morphology while it lacked phonological features. It also reveals that Okaz uses various discursive strategies to represent these textual features such as consensus, disclaimer, numbers and statistics, humanitarianism, illegality, vagueness, intertextuality and trope. Finally, the data analysis shows how do these discursive features employed to indicate a profound understanding of the Saudi culture and its society.
Pemberian Proton Pump Inhibitor Dibandingkan dengan Antagonis Reseptor-H2 pada Anak dengan Penyakit Refluks Gastrointestinal
Authors: Dwipoerwantoro Pramita G. , Yulman Annisa R
Published: May 2019

Latar belakang. Pada umumnya anak dengan penyakit gastroesofageal refluks (PRGE) diterapi dengan antagonis reseptor H2 (H2RA) atau inhibitor pompa proton (PPI). Keduanya merupakan obat yang tersering diresepkan pada PRGE anak, namun efikasi keduanya masih kontroversi.Tujuan. Untuk mengevaluasi penggunaan PPI dan H2RA pada anak dengan PRGE melalui telaah sajian kasus berbasis bukti.Metode. Pencarian literatur secara sistematik menggunakan instrumen pencari PUBMED, Cochrane, dan Google Scholar. Pencarian dibatasi pada literatur berbahasa Inggris, yang dipublikasi selama 15 tahun terakhir, dan usia pasien 0–18 tahun. Studi dianggap memenuhi syarat bila dilakukan secara randomized-controlled trials, mengevaluasi PPI dan/atau H2RA untuk pengobatan GERD anak. Studi yang hanya berupa abstrak, yang hanya mengevaluasi selain non-klinis, dan laporan kasus diekslusi.Hasil. Studi kohort oleh Ruigomez dkk mencakup 8172 pasien dengan PPI (24 pasien dengan esomeprazole dan 8148 pasien dengan PPI lainnya) dan 7905 dengan H2RA. Karakteristik dasar keduanya serupa, namun anak dengan PPI cenderung lebih tua usianya. Luaran terkait keselamatan sebanyak 92 hanya pada PPI selain esomeprazole. Mattos dkk memperoleh 735 literatur, 23 studi (1598 pasien yang dirandomisasi) yang diikutsertakan dalam review sistematik. Delapan studi membuktikan bahwa PPI dan H2RA cukup efektif mengatasi manifestasi tipikal GERD. Studi lain menunjukkan bahwa omeprazole lebih unggul dibandingkan rantidin dalam pengobatan manifestasi refluks ekstra esofageal.Kesimpulan. Inhibitor pompa proton (PPI) atau H2RA dapat digunakan untuk pengobatan GERD pada anak. Omeprazol lebih unggul dibandingkan ranitidine pada pengobatan manifestasi refluks ekstra esophageal.
SOLAR ABSORBER WITH A STRUCTURED SURFACE – A WAY TO INCREASE EFFICIENCY
Authors: Mrňa Libor , Řiháček Jan , Šarbort Martin , Horník Petr
Published: May 2019

The basic idea of a solar absorber’s thermal gain increase is the keyhole effect utilization during which the radiation is absorbed by multiple reflections on cavity walls. The lattice of pyramidal or conical cavities on the solar absorber surface can be formed to create a structured surface leading to its overall absorptivity increase and to a reduction of the surface absorptivity dependence on the solar radiation incident beam angle changes caused by the daily and annual solar cycles. This contribution concludes the results of simulations of the effect of cavity geometry, geographical position and absorber orientation on its thermal gain with respect to the technological manufacturability of cavities. Furthermore, the real construction of the absorber with a structured surface using laser welding and parallel hydroforming is briefly described.
Papel do Terceiro Setor na Construção da Democracia Brasileira
Authors: Figueiredo Jéssica
Published: May 2019

A democracia no Brasil, desde a sua implementação, encontra sérias dificuldades para se firmar. Ao longo dos últimos anos, falhas do sistema representativo vem sendo apontadas e a teoria da democracia participativa cada vez mais defendida e difundida, levando à criação de alguns institutos de participação social. Nesse contexto, o artigo objetivou estudar como o terceiro setor brasileiro vem cumprindo o seu papel político na construção da democracia, considerando as mudanças na sua forma de atuação e a sua evolução também sob a perspectiva internacional. Em resultado, entende-se que a crise democrática brasileira somente poderá ser superada na presença de uma cidadania forte, que para ser conquistada, diante da baixa capacidade organizacional que historicamente se presencia nos Estados latino-americanos, precisa ser fomentada. Observa-se que o terceiro setor brasileiro vem crescendo e se fortificando e que o seu caráter reivindicatório se apresenta mais acentuado. Tal fenômeno decorre tanto da revalorização do princípio da participação popular no âmbito nacional, com a criação de alguns mecanismos, quanto do atual tratamento inclusivo dado pela ONU e pela OEA às suas organizações. É necessário, no entanto, que a participação política do cidadão continue a ser ampliada no Brasil, pois a sua presença na esfera pública é essencial numa verdadeira democracia.
Emigração, Cidadania e Soberania
Authors: Storti Claudia
Published: May 2019

O presente trabalho tem como objetivo fazer um exercício de comparação histórico-jurídica entre as visões presente e pretérita sobre as categorias emigração, cidadania e soberania. Para tanto, apresenta uma série de fatos contemporâneos acerca de violações a normas referentes à matéria, para, em seguida, apresentar o itinerário de formação de tais institutos na modernidade jurídica. Verificou-se o declínio do Estado de fronte à  globalização e a sua fragilidade e sua incapacidade no lidar com o problema, vez que as providências adotadas, na presunção que sejam traços de manifestação da sua força, são demonstração de sua fraqueza.
Humberto Ávila. Teoria dos Princípios: da definição à aplicação dos princípios jurídicos
Authors: Alvarenga Guilherme Emmanuel Lanzillotti
Published: May 2019

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Construção do Lugar Comum da Comunicação
Authors: Sgrignolli Ruth Carolina Rodrigues , Junqueira Michelle Asato
Published: May 2019

O presente artigo tem como objetivo analisar a importância da comunicação sob o aspecto jurídico, ou seja, o valor da comunicação como mecanismo assecuratório das bases do Estado democrático. Para tanto, o texto se propõe a destacar o pensamento de alguns filósofos e sociólogos que estudaram o assunto e analisar se é possível para o ordenamento jurídico vigente garantir um espaço comunicacional dentro de um cenário repleto de multiplicidade cultural e de discursos tão diversos. Em sendo possível, como garantir espaços de comunicação de forma a assegurar a integração social e, por consequência, uma sociedade mais coesa e mais livre.
Direitos e as Garantias Fundamentais no Processo de Impeachment
Authors: Neves Andrey Philippe de Sá Baeta , Brito Johnathan Rodrigues de
Published: May 2019

A Lei nº. 1.079/50, que regulamenta o impeachment, foi recepcionada em parte pela Constituição de 1988. Tendo em vista o impeachment ser um processo bastante peculiar e a Lei do Impeachment ter sido elaborada sob a vigência da Constituição de 1946, existem discussões quanto à sua natureza jurídica e aos princípios e às normas que devem incidir em sua implementação. Dessa maneira, o presente trabalho possui o objetivo de analisar a compatibilidade da Lei nº. 1.079/50 com os princípios processuais estabelecidos pela Constituição de 1988. Para tanto, foi utilizado nesta pesquisa o método dedutivo, sendo analisados os aspectos gerais do impeachment e, posteriormente, suas peculiaridades frente aos princípios constitucionais, penais e processuais penais. Assim, mesmo havendo posicionamentos distintos quanto à  natureza do impeachment, seu processo deve ser pautado nos princípios  constitucionais, sempre com o objetivo de serem preservados os direitos fundamentais do acusado pela prática de crime de responsabilidade. Não deixando de ser complexa a verificação da observância desses princípios na prática, devido à inerência política do impeachment e à  concepção de sua  lei ser anterior à ordem constitucional vigente.
Comparison of Enoximone, Amrinone, or Levosimendan Enriched St. Thomas’ Hospital Cardioplegic Solutions Used for Myocardial Preservation in Isolated Guinea Pig Hearts
Authors: Köksal Cengiz , Süzer Öner , Bozkurt A Kürsat , Köseoğlu Sebahat
Published: May 2019

Myocardial contractile function after cardioplegic arrest is often depressed and an ideal cardioplegic solution has not been developed yet. The aim of this study was to assess the efficacy of phosphodiesterase III inhibitors, amrinone and enoximone, and levosimendan, a novel Ca2+ sensitizing agent, on recovery of hearts after normothermic cardioplegic arrest when added to the St. Thomas’ hospital cardioplegic solution. In the control group, isolated guinea pig hearts were perfused in Langendorff apparatus and arrested with standard St. Thomas’ solution. In other groups, amrinone (10-5 mol.L-1), levosimendan (10-5 mol.L-1), or enoximone (10-4 mol.L-1) were added to the cardioplegic solution. In all hearts, intraventricular pressure, +dp/dtmax, -dp/dtmax, area under pressure-time curve, heart rate, coronary flow, lactate dehydrogenase and creatine kinase enzyme leakage, and oxygen consumption were measured. In the enoximone group, contractility force and +dp/dtmax, were found to be significantly high in the reperfusion and inotropic periods in comparison with other groups (p<0.05). -dp/dtmax and area under contractility-time curve values were significantly high in inotropic period in enoximone group (p<0.05). No statistically significant difference was noted in other groups. Cardioplegic solution enrichment with enoximone augmented mechanic functions in reperfusion period. No positive effect of amrinone or levosimendan was observed in this study.
Effect of Atropine and the Oxime HI-6 on Low-Level Sarin-Induced Alteration of Performance of Rats in a T-Maze
Authors: Krejčová Gabriela , Kassa Jiří , Vachek Josef
Published: May 2019

1. To study the influence of antidotes on low-level sarin-induced alteration of cognitive functions, male albino Wistar rats were exposed to three various low concentrations of sarin for 60 minutes in the inhalation chamber. One minute following sarin exposure, the rats were i.m. treated with the oxime HI-6 in combination with atropine. Control rats were treated with antidotes as experimental rats but exposed to the pure air instead of sarin. Cognitive functions of the rats were tested using a T-maze where spatial memory and spatial orientation were evaluated. The performance of sarin-exposed and treated rats in the T-maze was tested several times within six weeks (single exposure) or five weeks (repeated exposure) following inhalation exposure to evaluate cognitive impairments. 2. In the case of single exposure to sarin, no statistically significant differencies between the performances of the control and the experimental groups in the alteration of spatial memory and spatial orientation were observed. The repeated exposure of treated rats to clinically asymptomatic dose of sarin (LEVEL 2) did not change the effect of low-level sarin exposure on spatial memory of the experimental rats compared to the single exposure to the same dose of sarin. 3. The decrease in the T-maze performance of the control rats was caused by the impairments of rat’s mobility due to the features of a solution of antidotes.
Serum C-Reactive Protein and Interleukin6 Levels in Neonatal Sepsis
Authors: Içağasioğlu Dilara , Çaksen Hüseyn , Sütçu Idris , Cevit Ömer
Published: May 2019

In this article, we studied complete blood count, serum C-reactive protein (CRP) and interleukin (IL-6) levels in 30 newborn infants with sepsis at admission, in the 24th hour of admission and at the end of the treatment. Our purpose was to determine the relationship among these parameters in the early diagnosis of neonatal sepsis. In our study, there was not a significant difference in white blood cell (WBC) and thrombocyte count among the values of the first, 24th hour and end of therapy in the study group (P>0.05). However, there was not a significant difference in B/N ratio among the values at admission, 24th hour and end of therapy in the study group (P>0.05). Both serum CRP and IL-6 levels were found to be significantly higher than those of control subjects at the beginning (P<0.05). Similarly, the values obtained on the 24th hour were also elevated. However, at the end of therapy both decreased to normal level (P<0.05). Based on these data, we think that serum CRP levels only which is a simple method may be used in the diagnosis of neonatal sepsis. However, WBC and serum IL-6 levels may be useful to establish mortality, because there was a statistically significant difference for these parameters between the survivors and deaths (P<0.05).
Fiscal stimulus and unemployment dynamics
Authors: Kuo Chun-Hung , Miyamoto Hiroaki
Published: May 2019

Focusing on both hiring and firing margins, this paper revisits effects of fiscal stimulus on unemployment. We develop a DSGE model with search frictions where job separation is endogenously determined. The predictions of the model are in contrast with earlier studies that assume exogenous separation. Our model can capture the empirical pattern of responses of the job finding, separation, and unemployment rates to a government spending shock, obtained from a structural VAR model with the US data. However, our model fails to capture the response of vacancies and the volatility of unemployment. We discuss the roles of cyclical movements of matching efficiency and labor force participation to fix this model’s shortcoming.
Surgical prophylaxis of bleeding during an the operative delivery in a patient with HELLP syndrome
Authors: Murashko Andrei V. , Sonich Margarita G. , Sulina Yana Y. , Timofeev Sergei A. , Ischenko Anatoliy I.
Published: May 2019

Background

HELLP-syndrome is rare, but it causes serious pregnancy complications with significantly increased maternal and perinatal morbidity and mortality. To date there is no agreement on its pathophysiology. The only treatment is an emergent delivery, which in turn increases the number of preterm newborns and does not always improve the patient’s condition in a close-time period with a high-risk of postpartum bleeding. To reduce the risk of uterine bleeding in this group of patients, we proposed to use a preventive application of compression sutures to the uterus during surgical delivery.

Case presentation

The management of HELLP syndrome in a pregnant woman with a multiple pregnancy (twins) at 34 weeks’ gestation with a favorable outcome is presented. Compression sutures: the B-Lynch and two circular sutures were applied to the uterus to prevent bleeding.

Conclusion

HELLP syndrome is a dangerous, sudden and rapidly progressive complication that threatens the life of the mother and fetus. Appliance of preventive compression sutures could reduce blood loss. However, for a wider use of the method, multicenter clinical trials are needed.
L
∞ in physics and in Georgia
Authors: Stasheff Jim
Published: May 2019

Here is a sketch of a few of the connections between Prof. Nodar Berikashvili and his school and higher homotopy structures.
A Law of Large Numbers in the Supremum Norm for a Multiscale Stochastic Spatial Gene Network
Authors: Debussche Arnaud , Nguepedja Nankep Mac Jugal
Published: May 2019

We study the asymptotic behavior of multiscale stochastic spatial gene networks. Multiscaling takes into account the difference of abundance between molecules, and captures the dynamic of rare species at a mesoscopic level. We introduce an assumption of spatial correlations for reactions involving rare species and a new law of large numbers is obtained. According to the scales, the whole system splits into two parts with different but coupled dynamics. The high scale component converges to the usual spatial model which is the solution of a partial differential equation, whereas the low scale component converges to the usual homogeneous model which is the solution of an ordinary differential equation. Comparisons are made in the supremum norm.
Die Vermarktlichung von Wildnis. Lebendige Waren, Companionability und Encounter Value beim Mustang Makeover Germany
Authors: Pütz Robert
Published: May 2019

From a social studies of marketization perspective this paper deals with the commodification of wild horses. It tackles with three questions: How are (wild) animals commodified in markets? How are lively commodities being valued and priced? How does the liveliness of the commodity influence the processes of marketization and vice versa how is the animal affected by being handled as a commodity? I draw on Haraway’s concept of encounter value and develop the idea of companionability as core concepts guiding the analysis.
A COMPARATIVE STUDY ON THE SHELF LIFE OF THE YOGURTS PRODUCED FROM COW AND BUFFALO MILKS
Authors: SARICA Ercan , COŞKUN Hayri , KEMER İlker Can , SAMUR Ezgi Seher , ÇİFÇİ Fatma Merve , AKTAŞ Ayten , ERER Hilal , VERGİLİ Emine
Published: May 2019

In this study, it was aimed to
study to compare the shelf life of yogurts made from cow and buffalo milks. The
experimental yogurt samples were kept at a refrigerator for 4 weeks and were
analyzed on days 1th, 7th, 14th, 21th
and 28th of storage. According to the results obtained, yogurt
samples (BY) made from buffalo milk had higher values of dry matter, fat,
acidity and L* values than those of yogurt samples (CY) made from cow milk. The
counts of total aerobic microorganisms, lactobacillus, lactococcus and yeasts
& molds of BY yogurt samples were lower than those of CY yogurt samples,
especially yeasts and molds counts of BY samples (2.46 log CFU/g) were fairly
lower than those of CY samples (4.00 log CFU/g). The BY samples were highly
preferred by the panelists in every test period and the highest preference was
obtained at the end of the storage.
Tissue-specific knockout of E-cadherin (Cdh1) in developing mouse gonads causes germ cells loss
Authors: Piprek Rafal P , Kolasa Michal , Podkowa Dagmara , Kloc Malgorzata , Kubiak Jacek Z
Published: May 2019

The normal course of gonad development is critical for the sexual development and reproductive capacity of the individual. During development, an incipient bipotential gonad which consists of unorganized aggregate of cells, must differentiate into highly structured testis or ovary. Cell adhesion molecules (CAMs) are a group of proteins crucial for segregation and aggregation of different cell types to form different tissues. E-cadherin (Cdh1) is one of the CAMs expressed in the developing gonads. We used tissue-specific knockout of Cdh1 gene in OCT4+ germ cells and, separately, in SF1+ somatic cells of developing gonads. The knockout of E-cadherin in somatic cells caused decrease in the number of germ cells, while the knockout in the germ cells caused their almost complete loss. Thus, the presence of E-cadherin in both the germ and somatic cells is necessary for the survival of germ cells. Although the lack of E-cadherin did not impair cell proliferation, it enhanced apoptosis, which was a possible cause of germ cell loss. However, the somatic cells of the gonad differentiated normally into Sertoli cells in the testis cords, and into follicular cells in the ovaries. The testis and ovigerous cords maintained their integrity; they were covered by continuous basement membranes. The testicular interstitium with steroidogenic fetal Leydig cells did not show any noticeable changes. However, in the female gonads, because of the lack of germ cells, the ovarian follicles were absent. The sex determination and sexual differentiation of the gonad were not impaired. These results underscore an important role of E-cadherin in germ cell survival and gonad development.
Mil mundos en un mundo: imagen e imaginación política en la prensa marginal madrileña, 1968-1978
Authors: Molina Agudo Inés
Published: May 2019

El presente trabajo examina el fenómeno de la prensa marginal madrileña, las producciones editoriales clan- destinas que circulaban en la ciudad de Madrid durante los primeros años de la Transición democrática. Par- tiendo de los Mayos globales y las reflexiones sobre los medios de comunicación que estos impulsaron, se tra- zará una genealogía de prácticas, miradas y estrategias de subversión que dan forma a la prensa libre, vinculán- dola con el desarrollo de la prensa marginal durante la década de los 70 en Madrid. Al mismo tiempo, este tra- bajo se presenta como una tentativa teórico-metodoló- gica que toma la mirada y la imagen como herramientas analíticas de gran potencial epistemológico para el estu- dio de la Transición española.
Espectadoras privilegiadas en la convivencia de María de Mendoza y su hija María Sarmiento con las comunidades religiosas de su patronato
Authors: Ramiro Ramírez Sergio
Published: May 2019

Con el aumento en el número de patronatos nobiliarios sobre monasterios y capillas funerarias durante el siglo XVI, las familias patrocinadoras se aseguraron lugares privilegiados desde los que asistir a los oficios religiosos en la iglesia, generalmente tribunas o habitaciones provistas de vanos que per- mitiesen una correcta visualización del altar mayor. En este artículo se analizan los problemas de convivencia que se pro- dujeron a la hora de conciliar los intereses de ambas partes y como estas preeminencias tuvieron su impacto en la arquitec- tura de estos edificios. Con este objetivo se estudia la influen- cia de la vida conventual en María de Mendoza (1508-1587) y su hija María Sarmiento (1526-1604), las cuales transfor- maron sus propias casas en establecimientos religiosos.
En-Clave de género. Las mujeres fuertes del Antiguo Testamento en la Capilla de la Virgen de Guadalupe de las Descalzas Reales
Authors: Álvarez Seijo Begoña
Published: May 2019

En el presente artículo se pretende visibilizar y analizar el ciclo pictórico de la capilla de la Virgen de Guadalu- pe del monasterio de las Descalzas Reales, por ser una capilla creada por una mujer para mujeres. Además, el estudio se centrará en la importancia del programa dedi- cado a las mujeres fuertes del Antiguo Testamento, ya que es un tema poco frecuente en el Barroco español. En consecuencia, se estudiará la relevancia del monasterio como centro de poder femenino, así como la relevancia de las figuras de Sor Ana Dorotea, monja real y promo- tora de esta capilla mariana, ya que su personalidad y educación fueron motor indispensable para que se crea- se este grupo pictórico con la mujer como absoluta pro- tagonista, y de Sebastián Herrera Barnuevo, la mano que ejecutó magistralmente la iconografía ideada por la clarisa descalza.
Experiencias artísticas a finales de la última dictadura argentina: entre lo local y lo internacional
Authors: Soledad González Alejandra
Published: May 2019

A inicios de la década de 1980, mientras comenzaba el agotamiento de la última dictadura argentina, adquirieron visibilidad algunos grupos de artistas cuyas prácticas materiales y simbólicas cuestionaban al campo artístico y, en ciertas ocasiones, también al macrocosmos social. En este artículo se reconstruye un caso levemente estudiado: la Agrupación para el Desarrollo de Experiencias Visuales. En las primeras tres secciones se indaga la gestación del grupo en la ciudad de Córdoba, dentro del contexto de la política cultural nacional, cuando consiguieron un taller y concretaron una exposición fundacional. Posteriormente, se ensaya una lectura, en clave sociológica de “estructuras de sentimientos”, de unas experiencias donde confluyeron: artesanía, cine, escultura, fotografía, instalación, literatura y pintura. Finalmente, se exploran nueve trayectorias de expositores que acreditaban redes locales e internaciona- les. Para emprender esta investigación se recurrió a un enfoque transdisciplinar de Historia Cultural y al análisis de variados documentos escritos, orales y visuales.
Impact of Operational Condition on the Membrane Permeate Flux and Quality of Domestic Wastewater Treatment using Hollow Fiber Membrane Module in Cross-Flow Mode
Authors: Khan Bushra  , Liu Mei  , Natsagdorj Khaliunaa  , Rooha Khurram  , Zhan Wang
Published: May 2019

In this paper, the impacts of process conditions on the membrane permeate flux (J) and the quality of effluent in domestic wastewater treated by using 0.1 μm hollow fiber membrane module in cross-flow mode were quantificationally analyzed with a statistical method. The results showed that (1) trans-membrane pressure (TMP), crossflow velocity (u), mixed liquor suspended solids (MLSS), dissolved oxygen concentration (DO), pH, temperature (T), sludge retention time (SRT) and hydraulic retention time (HRT) were all the influencing factors of the permeate flux. Among them, MLSS, T, SRT and HRT are negative contributors to the permeate flux while TMP, u, DO and pH are positive contributors. In addition, the quantitative relationship between the permeate flux and process conditions is established. (2) TMP and u had no effect on the quality of effluent COD while other operating conditions were the influencing factors. Only HRT had a negative effect on the quality of effluent NH3-N. The quantitative relationships between COD, TOC, NH3-N and process conditions were also established. These mathematical expressions, to some extent, could be used to optimize operational conditions, predict the permeate flux and efficiency of domestic wastewater treatment using hollow fiber membrane module in cross flow mode.
The Role of Attitudes in Editing the Effect of Perception of Benefits and Use of Use on Interest in Using Internet Banking
Authors: Indrayana I Putu Dony , Suciani Luh
Published: May 2019

This study aims to determine the effect of perceived benefits and the ease of use of interest in using BRI internet banking with the role of attitude as mediation. The location of this research was conducted at PT Bank Rakyat Indonesia Denpasar Branch Renon. The population in this study were BRI internet banking users, which numbered 3,641. This study uses a type of quantitative data, using primary and secondary data sources, and data collection techniques used are interviews, documentation, and using instruments in the form of questionnaires. Sampling in this study is proportional to each customer. While the determination of respondents used random sampling by lottery on the customer list. The minimum number of samples targeted in the study were 98 people. The analysis technique used is Structural Equation Modeling (SEM) with a variance based or component based approach with Partial Least Square (PLS).

The results of this study indicate that: 1) Perception of benefits has a positive and significant effect on attitudes, 2) Ease of use has a positive and significant effect on attitudes, 3) Perception of benefits has a positive and significant effect on interests, 4) Ease of use has a positive and significant effect on attitudes, 5) Perception of benefits has a positive and significant effect on interest through attitudes, 6) Ease of use has a positive and significant effect on interest through attitude.
Synthesis, Partial Characterization of Chitosan-Iron Complex and its Effects on Alloxan Induced Diabetic Mellitus in Wistar Albino Rats
Authors: O. A. Oseni , S. A. Olagboye , O. T Adams , Akintayo Tope Akintayo
Published: May 2019

This present study was undertaken to synthesize and investigate the activity of chitosan-iron complex on alloxan induced diabetic Wistar albino rats. Chitosan was extracted from crab shell and used to form complex with iron salt. Eighteen Wistar Albino rats were acclimatized and divided into three groups of six animals each weighing between 178 and 237g for bioasay: the control; the diabetic and the treated. Alloxan induction caused relative decrease in the weight of the animals in the induced group (153.64g) than control (194.21) and chitosan-iron complex treated (166.19g) groups. Results of blood glucose showed that the group treated with 50mg/kg body weight alloxan possessed higher glucose level (199mg/dL) than the control (57.67mg/dL) and chitosan-iron complex treated (55.33mg/dL) groups. The activity of chitosan-iron complex was evaluated on the plasma, liver and kidney of the rats. The results of the other studied parameters showed that chitosan-iron complex reversed the effects of the alloxan to almost control in the studied organs as the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglyceride, total cholesterol; HDL-Cholesterol, malondialdehyde (MDA), catalase and reduced glutathione were effectively regulated. It can therefore be inferred that chitosan-iron complex can be used in  the treatment of diabetes and diabetic related complications.
Coal in the twenty-first century: a climate of change and uncertainty
Authors: Madhavi Madhu , Nuttall William J.
Published: May 2019

Coal presents a particular set of challenges when balancing energy policy goals. Despite presenting viable solutions to the problems of energy security and global energy poverty, coal struggles, given its greenhouse-gas drawbacks, in a world of increasingly harmful climate change. Notwithstanding the harm caused to the environment, coal remains an expanding low-price route to meeting local energy needs. It is forecasted to remain a major global resource for the foreseeable future. In the short term it is predicted to have a 26% share of the global energy mix. Recent years have witnessed severe deviations from previously stable trends in coal markets and policy dynamics. According to the predictions by the International Energy Agency, a variety of factors ranging from the planned phase-out of coal in countries such as Denmark, France and the UK, to changes in policy in China and import-dependency in India, and demand drop in the US have together resulted in the largest decline in coal production since 1971 in 2015. This paper seeks to outline basic coal facts, recent market trends and directions globally and provides an overview of issues shaping the future of coal in the twenty-first century.
Existierende Widersprüche. Ein Kommentar zu Karl Löwiths Randbemerkungen
Authors: Fagniez Guillaume
Published: May 2019

Ende 1987 widmete die Bayerische Staatsbibliothek München dem berühmten japanischen Schriftsteller Mori Ôgai (1862-1922) eine Austellung, in der neben anderen Zeugnissen seines Lebens auch verschiedene Dokumente seiner zur Zeit seines Aufenthalts in Deutschland ausgebrochenen Kontroverse zwischen ihm und dem deutschen Geologen Edmund Naumann (1854-1927) gezeigt wurden. Unter diesen fand sich die japanische Fassung einer Stellungnahme des Philosophen Karl Löwith zu dieser Kontroverse. In Sendai, wo Löwith seit 1936 an der kaiserlichen Universität unterrichtete, hatte der Kunsthistoriker Daigorô Sawayanogi seinem deutschen Kollegen die zwei gegen Naumann gerichteten Artikel Ôgais vorgelegt. Im Januar 1938 schrieb Löwith an Sawayanogi einen 9-seitigen Text, der seine «Randbemerkungen» zu den Aufsätzen Ôgais zusammenfasste.
Applying the occupational justice framework in disability policy analysis in Namibia
Authors: Chichaya Tongai F , Joubert Robin , McColl Mary Ann
Published: May 2019

INTRODUCTION: The purpose of the study was to compare the existing disability policy in Namibia with those of other southern African countries to determine whether the former would require revisions. There were two objectives: to apply the occupational justice framework to analyse the National Policy on Disability of Namibia, to conduct an comparative analysis of the National Policy on Disability of Namibia and selected disability policies and policy environments in Botswana, Lesotho, Malawi, South Africa, Zambia, and Zimbabwe taking into consideration the United Nations' Convention on the Rights of Persons with Disabilities (UNCRPD) METHODS: A qualitative analytical approach was used to conduct a document review of the Namibia disability policy and to provide a comparative analysis of the Namibia disability policy with those of selected southern African countries using the disability policy analysis lens. Critical disability theory provided the overarching theoretical framework. Discourse analysis was applied to identify themes. FINDINGS: Embedded occupational marginalisation and deprivation were evident in the Namibian disability policy. A new type of occupational injustice emerged that can best be described as Occupational inconsideration among disability policy makers, whereby occupational rights for persons with disabilities are of secondary focus when disability policies are formulated. CONCLUSION: Namibia's disability policy was considered inadequate in terms of addressing occupational rights according to the occupational justice framework. Similarly, Namibia and other southern African countries have not significantly progressed with domesticating the UNCRPD. The findings have implications for disability policy formulation and occupational justice practice in Namibia in particular and in southern Africa in general. Key words: Occupational justice; disability policy; policy analysis; occupational participation; African countries.
Experiences and perceptions of Return to Work (RTW) by clients with major depressive disorder in an extended sick leave period
Authors: Saonatse Lebohang , De Witt Patricia Ann , van Niekerk Matty
Published: May 2019

INTRODUCTION: Major Depressive Disorder (MDD) may cause difficulties that can influence employment. Although clients with MDD are typically expected to return to work (RTW) early, most are given the maximum duration of sick leave subsidised by their medical aid scheme, to recover. This study explored the lived perceptions and experiences of clients with MDD whilst on extended sick leave. METHODS: The study used a descriptive phenomenological qualitative study design. Data were collected through informant interviews. An inductive content analysis was used to analyse the data. FINDINGS: Eight participants were included in the study, of which 75% (n=6) were females and 25% (n=2) were males. One theme emerged from the data, namely 'waiting to RTW with three categories (1) 'ruminating about RTW, (2) 'fears about RTW and (3) 'social pressures to RTW CONCLUSION: The period of waiting to RTW after hospitalisation was found to be stressful due to perceived work issues and rumination about work politics that were perceived to contribute to the illness. However, social pressures also play a vital role as a facilitator to RTW. These findings have implications for vocational preparation by occupational therapists during this extended sick leave period. Key words: Major Depressive Disorder, Perceptions, Experiences, Return to Work.
Roles, rituals and emotional regulation of rugby players at different competitive levels
Authors: Hough Petronella A , Nel Mariette , de Klerk Trohandi , Human Janine , Voight Tyler , van der Neut Jana
Published: May 2019

Globally, people engage in the game of rugby as spectators, players and organisations on many different competitive levels for the purpose of leisure, work and play. It is performed on both amateur and professional levels and engaged in by male and female players ranging from pre-school to adults. The purpose of the study was to describe and compare the roles, rituals and emotional regulation, on and off the field, of male rugby players on three different competitive levels in the Free State, South Africa. A cross-sectional study design was used amongst rugby players (n=45); 1 team per competitive level (3 levels). The results of the study showed significant differences with regards to roles that rugby players on the different competitive levels assume and the importance which they ascribe to each role. Variations exist in the rituals that the rugby players on the different competitive levels perform before and during a game of rugby. The degree to which situations are experienced as stressful differs across the three competitive levels. Across these levels, the use of positive verbal and non-verbal expression is used more than negative expression. Across all three levels rugby players use emotional suppression more than situational reappraisal as an emotional regulation strategy. Additional factors and the comparison thereof on different competitive levels should be investigated in future studies. Key words: Roles, rituals, emotional regulation, occupation, rugby
Editorial
Authors: Vásquez Tomás Antonio
Published: May 2019

Con la presente edición, Pedagogía y Saberes llega a su número diez. Diez números a través de los cuales han pasado variadas temáticas y perspectivas en torno a la educación y la pedagogía, tales como, ética, enseñanza de las ciencias, educación comunitaria, constructivismo, educación ambiental, educación y comunicación, evaluación. En ellos se han recogido buena parte de las reflexiones, investigaciones y propuestas de docentes de la Facultad de Educación, de las demás facultades de la universidad y de fuera de ella. Estas diez ediciones han sido suficientes para que Pedagogía y Saberes se abriera un lugar en el intrincado y competido mundo de las comunicaciones y de las revistas educativas en particular Ella se ha convertido, pese a las irregularidades en su periodicidad, en un espacio de debate de las ideas pedagógicas y educativas, así como también, en un apoyo para el trabajo pedagógico de los docentes.
El estatuto del maestro hoy. Aportes para la discusión sobre la creación de un Instituto Nacional Superior de Pedagogía
Authors: Álvarez Gallego Alejandro
Published: May 2019

Este artículo es una versión ajustada de la ponencia que presentó el autor en el II Encuentro Nacional: Trayectos, lugares y umbrales de la pedagogía, organizado por el Instituto Nacional Superior de Pedagogia y la Universidad Pedagógica Nacional en agosto de 2006. En él se muestra cuál ha sido el paso del oficio del maestro ­entendido como funcionario­ a su profesionalización, y las posibilidades de que habría de ganar autonomía y mayor protagonismo como sujeto público, si se asume como intelectual. Muestra los cambios que se están produciendo en la sociedad contemporánea, y lo que les está ocurriendo a las Facultades de educación y a las Normales con estos cambios, para insinuar que un Instituto Superior de Pedagogía podría permitirle al maestro, entendido como un colectivo social, producir conocimiento para reconocerse y proyectar su trabajo más allá de las formas de control que la sociedad posindustrial está generando.