bluuebunny/crossref_metadata_2025 huggingface dataset:
Boswellia serrata normalizes altered haematological indices, attenuates pain and inflammation associated with adjuvant induced arthritis in rats
Authors: R DIVISHA , M USHA RANI , A GOPALA REDDY , B KALA KUMAR
Published: December 2022

A study was carried out to evaluate the anti-arthritic potential of Boswellia serrata on haematological parameters, pain and inflammation associated with adjuvant induced rheumatoid arthritis in rats. Thirty male Wistar rats were randomly divided in to 5 groups. While Group 1 served as normal control, Group 2 served as arthritic control, Groups 3, 4 and 5 served as treatment groups. Arthritis was induced in animals from Groups 2 to 5 with 0.1 ml of Freund's complete adjuvant injected intradermally into the foot pad of hindlimbs. Consequently, the onset of rheumatoid arthritis was indicated by hyperalgesia and inflammatory signs which were assessed by paw volume, paw diameter and paw withdrawal latency. Treatment protocol was followed from 3rd to 21st day, with Boswellia serrata given orally as methanolic extract at 500 mg/kg b.wt. to Group 3, meloxicam given subcutaneously at 1 mg/kg b.wt to Group 4 and both the drugs given concurrently to Group 5. The drug effects were evaluated on paw parameters and haematological indicators to depict the extent of paw inflammation and its subsequent amelioration. Conclusively, a major curative effect was witnessed with Boswellia serrata when compared to meloxicam.
Differential expression of TGF-β and IL-1R2 genes during endometritis infection in Egyptian buffalo
Authors: OTHMAN OTHMAN E , MABROUK DALIA M , EL-KADER HEBA A ABD , ALAM SALLY A , EL-AZIEM SEKINA H ABD
Published: December 2022

Contamination of the uterine lumen with bacteria occurred in bovid within the first week after parturition. The bacterial infection causes the persistent inflammation in the endometrium leading to the infertility and huge economical loss in animal production. TGF-β and IL-1R2 genes are involved in innate immune recognition of pathogens and the inflammatory response. This study aimed to compare the expression of these two genes in uteri samples of endometritis-infected and apparently healthy buffaloes using QT-PCR. The uteri samples were collected from endometritis-infected and normal buffaloes. Bacterial examination of uteri from endometritis-infected buffaloes showed the presence of bacterial contamination with E. coli, P. Klebsiella pneumonia and/or P. vulgaris. RNA was extracted from uteri of infected and normal animal, and cDNA was synthesized for QT-PCR. Using GAPDH as a housekeeping gene, the gene expression of two tested genes was assessed and the results showed that the expression of TGF-β and IL-1R2 genes was up-regulated in infected animals compared to control by 11.39 and 12.99 folds, respectively and this increase of gene expressions was highly significant. In conclusion, the gene expression assessment of important innate immune genes—like TGF-β and IL-1R2 genes can help to establish new approaches for the improvement of the immune response of buffalo through marker-assisted selection of animals characterized by superior innate immunity system.
Assessment of different stages of parthenogenetic embryos for production of embryonic stem cell like colonies
Authors: PATHAK JUHI , KHARCHE S D , GOEL ANJANA , SIKARWAR A K S , SARASWAT SONIA , RANJAN RAVI , GANGWAR CHETNA , SINGH S P , GOEL A K , CHAUHAN M S
Published: December 2022

Parthenogenetic activation of oocytes has gained new interest in recent years as an alternative approach to create embryos with no reproductive purpose for research in areas such as assisted reproduction technologies itself and for derivation of clinical grade pluripotent embryonic stem cells for regenerative medicine. In this study, we described the production of goat parthenogenetic ES like cells from different stages of parthenogenetic embryos. We compared the source material on the pESCs outgrowth and culture. 8-16 cell stage embryos, morula, blastocysts and ICM (inner cell mass) from hatched blastocysts produced from chemical activation were cultured on goat fetal fibroblast monolayer in stem cell culture media. Colonies were passaged when signs of differentiation were visible. ESC like colonies were cultured on feeder cells in the presence of hLIF however, some ESC like colonies were also cultured in absence of hLIF for random differentiation. In our study, ESC like colony formation with ICM of hatched blastocyst was comparatively higher as compared to blastocysts while ESC like colony formation with blastocysts and ICM of hatched blastocyst was significantly higher as compared 8-16 cells and morula. It is observed that inner cell mass source is an important criterion for the ES like cells derivation in goats. Also, in comparison to the expanded blastocysts (80.10%), hatched blastocysts showed higher (86.06%) attachment rate and primary colony formation rate. ESC like colonies in absence of hLIF differentiated in vitro into epithelial like and neuronal like cells. Undifferentiated ESC like colonies stained positive for alkaline phosphatase, SSEA-3 and OCT-4.
Association of lactation persistency with genetic variants of bovine growth hormone gene in Indian Sahiwal cows
Authors: SACHAN SHWETA , GUPTA I D , VERMA ARCHANA , GUPTA A K , R VINEETH M , KUMAR ANSHUMAN
Published: December 2022

The aim of this study was to determine the associations of persistency with genetic variants of bovine growth hormone (bGH) gene in Indian Sahiwal cows. The data pertaining to the monthly test day milk yield (MTDMY) and first lactation length (FLL) of 305 lactating Sahiwal cows over a period of 23 years (1993–2016) were subjected to analysis. Persistency of milk yield was estimated by using test day based ratio method and Wilmink b function. Mean LL was 220.06±8.15 days in all studied Sahiwal cows, however, 276.67±10.25 days in cows with ≥100 days of LL and having 500 kg MY. The peak of milk yields was achieved at third TD of the first lactation. Macrophage stimulating protein 1 (MspI) and Arthrobacter luteus1 (AluI) restriction endonucleases were used to digest the amplified regions in intron 3 and exon 5, respectively of bGHgene. The bGHMspI restriction fragment length polymorphism (RFLP) yielded TT, CT and CC genotypes, whereas bGH-AluIRFLP yielded CC, CG and GG genotypes. Significant association was found between first lactation persistency estimated using test day based ratio method and bGH-MspI polymorphism. No significant association was found between first lactation persistency and bGH-AluI polymorphism. In summary, results of present study revealed that the TT genotype of bGH–MspI gene in Sahiwal cows has better lactation persistency than other genotypes.
Relationship between plasma, saliva, urinary and faecal cortisol levels in pigs
Authors: MOHAN N H , NATH ANKIT , THOMAS R , KUMAR S , BANIK S , DAS A K , DAS R K , SARMA D K
Published: December 2022

Blood collection for assessment of stress markers such as cortisol, involves restraining and induction of stress on animals. The present study examined the relationship between circulating cortisol levels with its levels in other biological sources (saliva, urine, faeces) to assess utility of non-invasive methods of sample collection for stress assessment in crossbred pigs (Hampshire × Ghungroo). Urine samples were collected after 1 and 2 h of blood and saliva collection, whereas faecal samples were collected after 24 and 48 h of initial sample collection. Mean cortisol levels in plasma and saliva was positively correlated. The correlation between plasma cortisol and second hour mean urinary cortisol values was higher compared to first hour samples. The faecal reactive metabolite levels were weakly correlated to plasma, saliva and urinary cortisol levels. It is concluded that the salivary cortisol values reflect its plasma levels at the time of collection most closely amongst the biological samples studied.
Introducción de classe prácticas en la enseñanza de ciencia en una institución pública del estado de Sergipe/ Brasil
Authors: Santos João Soares , Anjos Érika Cristina Teixeira dos , Avendaño Fernando Carlos
Published: December 2022

O presente trabajo tem a finalidade de Analizar la Importancia del uso de las Metodologías activas en la Construcción del Conocimiento de Ciencias de la Educación Fundamental bajo la Perspectiva del Desarrollo de Competencias y Habilidades. Por lo tanto la Enseñanza de las Ciencias es muy importante, ya que aborda los principios científicos generales y, también, aplicaciones tecnológicas. Los conceptos y teorías científicas no tienen valores en sí mismos, como sistemas abstractos de pensamiento, sino como instrumentos que nos ayudan a entender el mundo en el que vivimos con el fin de orientar nuestras acciones a nivel individual y social. La práctica vinculada a la teoría hace mucha diferencia para una clase contextualizada, donde los estudiantes pueden ver la importancia de los contenidos abordados en la enseñanza de las Ciencias, además de ofrecer a los mismos una mayor claridad para que puedan realmente interpretar o sea hacer parte del estudio en cuestión. . Es visible hoy en día la necesidad de la experimentación durante las clases como instrumento de enseñanza, porque el estímulo y el interés de los estudiantes pasa a ser mucho mayor, ya que los mismos pueden visualizar el contenido de forma diferente, o sea, pasan a analizar ciertas cuestiones como si hicieran parte de ella. Por lo tanto, la práctica experimental tiene un papel más amplio de lo que se espera, porque desarrolla en los alumnos un mayor interés, además de despertar habilidades que no aparecía en las clases teóricas, por ejemplo.
A importância das aulas práticas e alternativas para ensinar ciências no ensino fundamental nos 6° anos da escola municipal de ensino fundamental manoel cardoso das virgens, na cidade de Umbaúba- Sergipe
Authors: Santos João Soares , Anjos Érika Cristina Teixeira Dos , Avendaño Fernando Carlos
Published: December 2022

O Ensino de Ciências é muito importante, pois aborda princípios científicos gerais e, também, aplicações tecnológicas. Os conceitos e teorias científicas não têm valores em si mesmos, como sistemas abstratos de pensamento, mas enquanto instrumentos que nos auxiliam a compreender o mundo em que vivemos de modo a orientar nossas ações, a nível individual e social. É na época de escola que os alunos aprendem a gostar ou não da matéria de Ciências, pois a mesma possibilita a compreensão dos acontecimentos passados, ou seja, permite entender os processos que regem nossa vida na Terra. É possível verificar a expectativa dos educandos durante a semana para ter aulas de Ciências, pois sempre perguntam o que será passado de diferente na aula.
A Educação Feminina no Livro A Vindication of the Rights of Woman de Mary Wollstonecraft (1792)
Authors: Candeloro Campoi Isabela , da Silva Massuia Bruna Letícia
Published: December 2022

A principal obra em defesa dos direitos das mulheres no século XIX, considerada fundadora do feminismo moderno, A Vindication of the rights of woman de Mary Wollstonecraft foi publicada em 1792 em Londres. O artigo aqui apresentado discute as expectativas sobre a educação feminina naquele contexto, a receptividade da obra no século seguinte, além de apresentar aspectos biográficos de Wollstonecraft. A autora apresenta críticas ácidas ao modelo de ensino feminino em voga no século XVIII e rebate intelectuais que tratam do tema educação, tais como Jean Jacques Rousseau, Pierre Roussel e Edmund Burke. Também foram consideradas as profundas transformações que afetaram o mundo ocidental e o universo das ideias com foco na construção dos papéis de gênero.
Diálogos Interdisciplinares Entre Administração e Literatura
Authors: Fernandes Barreto Vanderlei
Published: December 2022

A presente investigação pretende discutir quatro eixos da Administração Contemporânea: Cultura Organizacional, Ética, Liderança, Gestão, correlacionando com o texto literário. Compreendemos a Literatura como forma de arte e, como tal, ligada ao homem e seu contexto histórico e cultural, mostrando-se fruidora de conhecimentos interdisciplinares. Discute-se como a literatura pode trazer compreensão sobre questões da área da Administração e como este saber pode trazer percepções sobre o homem e suas relações na sociedade, assim como as duas áreas do conhecimento podem contribuir para a compreensão do homem em sociedade. Esse exercício analítico interdisciplinar evidencia a importância de estabelecer diálogos profícuos entre os dois sistemas de conhecimento.
SANTOS, Gevanilda. Relações raciais e desigualdade no Brasil. São Paulo: Selo Negro, 2009.
Authors: Felix da Cruz Medrado Tatiane
Published: December 2022

A história do negro no Brasil foi sempre contada sob a perspectiva do homem branco, o qual obviamente enalteceu em sua versão os feitos dos colonizadores, dos generais, dos grandes nomes da elite nacional. É historicamente recente o entendimento da necessidade de mostrar a narrativa por outra ótica, isto é, pela visão do povo negro e as consequências da escravidão na construção de uma estrutura desigual do país. Em Relações Raciais e Desigualdades no Brasil, Gevanilda Santos apresenta um ponto de vista histórico desligado da versão oficial ensinada por séculos na escola, e que descaracteriza o horror da escravidão.
A Estátua de Borba Gato
Authors: da Graça Costa Marcia Maria , Lobo de Arruda Campos Alzira
Published: December 2022

A estátua de Borba Gato é o eixo a partir do qual se estabelece uma reflexão sobre as relações entre a sociedade contemporânea e seus monumentos históricos. Em meio à tensão e ao caos urbano das grandes cidades, esses monumentos sobrevivem como lugares de memória. São sinais de reconhecimento e de pertencimento, elementos simbólicos do patrimônio memorial de uma comunidade. A memória social, e a consequente identidade que se apresenta na relação entre o bairro e a estátua, mostra-se difusa e complexa, entre a ideia da estátua como simples monumento, e a memória histórica ali representada. Memória da sociedade, simultaneamente como depositária da história objetiva e da história ideológica.
Avaliação Psicológica nos Processos de Alienação Parental
Authors: Perissini da Silva Denise Maria
Published: December 2022

O presente artigo expõe os principais aspectos da avaliação psicológica que deve ocorrer nos casos em que haja indícios suscitados de Alienação Parental (AP). Apresenta as dificuldades de aplicação da Lei nº 12.318/2010. A demora em iniciar os trabalhos periciais, a inepcia de alguns profissionais e a insuficiência e superficialidade de procedimentos acarretam a invisibilidade da AP nos processos judiciais. Ações incisivas de denúncias de casos de AP devem ser fomentadas para melhorarmos a qualidade das avaliações psicológicas, aprimorando a qualificação dos psicólogos e dando visibilidade à AP no contexto judicial, para facilitar as políticas públicas de atendimento às famílias, bem como a retomada da discussão da criminalização da AP como efetiva sanção ao(à) alienador(a).
Screening for depression and anxiety in medical and dental students who are forced into their field of study
Authors: Khan Sohail Ahmad , Khan Asvad A. , Ahmad Asiyah
Published: December 2022

Objectives:  We hypothesized that the students who are forced to enter the medical field by their parents may have a higher incidence of depression and anxiety.

 

Methods: A total of 210 medical and dental students were asked to fill out a form indicating their desire to enter medical college versus their parents’ wishes on an analogue scale. They were also asked to fill out screening forms for depression and anxiety.

 

Results: The students who selected the medical field by their parent’s wishes were found to have 1.2 times more anxiety & 1.96 times more depression.

 

Conclusions: The parents should consider their child's willingness to enter the medical field before forcing him / her into the medical school.
Misperception about epilepsy among common public in Balochistan
Authors: Muhammad Essa  , Gulandam  , Aman ullah Kakar  , Saleem Barech  , Ihsan ul haq zarkon  , Suhail Mari  , Muhammad Dawood  , Tahir Shah
Published: December 2022

Abstract

Background of the Study:

Epilepsy is a curable chronic neurological illness that is frequently associated to supernatural activity. Due to a lack of knowledge and awareness among the Common public. The objectives of this study were to determine common myths and misperception about epilepsy by analysing a comprehensive panel of variables in our local population. Methods: We conducted a face-to-face questionnaire interview survey in three different shopping malls 1000 people were randomly enrolled in this cross-sectional study at Quetta, Baluchistan, during the period of twenty-one august 2021 to 30 august 2021.

Results: A total of 1000 people were interviewed among them 220(22%) were male and 780(78%) were female. People of all age group were included in the study. Out of thousand people 419 (41.9%) says epilepsy is brain disease, 488 (48.8%) responds its ghost attack, 23(2.3%) believes its psychosis. 980(98%) respondents had heard about epilepsy. The aspects of knowledge tested were on causes, types, and management of epilepsy. Forty-nine (4.9%) people believes that cause of epilepsy is head trauma, 488 (48.8%) said its Ghost attack, 67 (6.7%) said it’s because of evil eye, and 293 (29.3%) peoples believes that epilepsy is caused by Black magic. 928 (92.8%) who believed on domestic stunts such as sniffing shoes is effective in epilepsy. This result was much surprising because in this era of modern medicine and technology, still superstitious believes prevail among large population

Conclusions: This study revealed a lack of awareness about epilepsy in Baluchistan, as well as the prevalence of both negative and favourable attitudes about Epilepsy. The study also emphasized to increase public awareness and epilepsy education initiatives to change public opinions and promote the use of standard epileptic treatment

Keywords: Epilepsy, Attitudes, Knowledge
Viewpoint. A new approach to floor loading
Authors: Hughes Alastair
Published: December 2022

Alastair Hughes sets out a proposal to simplify the Eurocode approach to floor loads by moving from an occupancy-based categorisation to one based on loading.
Technical Guidance Note Level 3, No. 2: Axial shortening
Authors: O'Regan Chris
Published: December 2022

This Technical Guidance Note concerns the concept of axial shortening – a phenomenon that occurs in vertical loadbearing elements within all structures, but whose effects are especially pronounced in those over 15–20 storeys high. Reinforced concrete frames are most prone to axial shortening due to the impact of shrinkage and creep on composite materials. This note covers the causes of axial shortening, how it is assessed and predicted, and the mitigation measures structural engineers and building contractors employ to counter its effects, particularly in relation to fit-out and facade installation following building construction. The note also refers to ways in which current codes of practice offer a means to analyse structures for axial shrinkage.
Viewpoint. An engineer’s guide to surviving the workplace
Authors: Blackhurst Scott
Published: December 2022

Scott Blackhurst draws on his experiences over a varied career to offer advice to young engineers embarking on theirs.
Formative assessment that bites
Authors: Haynes Jonathan
Published: December 2022

It is now an established fact that the learning cycle is greatly enhanced by timely and effective feedback. Formative assessment has become an indispensable vehicle to facilitate student engagement in the feedback process, even if they do not recognise they are receiving feedback. This paper, based on the winning entry to the Institution of Structural Engineers Excellence in Structural Engineering Education Award 2020, presents a review of some formative feedback events in which civil engineering students at the University of Salford participate. The cohorts studied cross six years (200+ students), and three programmes at FHEQ level 7. The study indicates that carefully designed feedback events can have a significant impact upon understanding of structural behaviour for students preparing for professional status.
Therapeutic Communication Strategy in Social Isolation Patient: A Case Study of Mental Health Nursing
Authors: Suhanda  , Apriansyah Ali , Oktriani Herni , Firmansyah Andan , Ramdani Vikri Haikal
Published: December 2022

Objective: To provide nursing care for socially isolated patients with therapeutic communication strategies for socially withdrawn patients.

Methods: The method used is descriptive qualitative with a case study approach. The sampling technique is a therapeutic communication strategy. The sample taken was 1 patient who experienced social isolation disorders. The participants used in this study were the patient Mrs. S is 36 years old, a woman with social isolation mental disorders. The process of assessing and establishing a diagnosis is focused on the main problem. Objective and subjective data becomes a reference for periodic evaluation of nursing implementation. The location of the research was carried out at the BLUD of the Banjar City Hospital on 25-28 May 2022.

Results: Based on the results of nursing care found signs and symptoms, namely with subjective data feeling lonely, feeling useless, verbal responses are lacking and very brief, while objective data is the client looks a lot silent and doesn't want to talk, facial expressions are less radiant, less eye contact. The nursing problem found is social isolation. The intervention given is therapeutic communication.

Conclusion: Intervention of therapeutic communication strategies to help clients converse and want to get acquainted with their roommates in social isolation patients. This can happen if the patient can focus on doing therapeutic communication.
Design of an Information System for Testing the Blood Characteristics on Increasing the Impact of Vibration using a Prototype “Blood Shaker Machine”
Authors: Pramudita Jessica Juan , Susanto Edy , Rusyadi Luthfi
Published: December 2022

Objective: The general purpose of this research is to design an information system based on the application of blood characteristics testing on platelets to increase the impact of vibration by using a "Blood Shaker Machine" examined through a Haematology Analyzer (HA) and Peripheral Blood Smear (SADT) at any changes in the increase in vibration.
Method: The method used in this study is to design an application-based system on the "Blood Shaker Machine" and test the increase in vibration on changes in blood quality both in terms of the number and morphology of the platelets.
Result: Significant changes in the morphology of erythrocytes and platelets in the 10 Hz vibration group for 15 minutes also indicated a change in the quality of blood cells, both erythrocytes and platelets. 
Conclusion: There is a significant difference in erythrocyte morphology changes between before and after being vibrated at 10 Hz with a p value of 0.014 and There is a significant difference in platelet morphology between before and after being vibrated at 10 Hz with a p value of 0.000.
Validity Test of The Acupressure Model Integrated Spiritual Coping Skill as an Effort to Reduce Anxiety Level in Chronic Kidney Disease
Authors: Supriyadi
Published: December 2022

Objective: Collecting information and testing validation for the design of an acupressure model integrated with spiritual coping skills as an effort to reduce anxiety levels in patients with chronic kidney disease proves that acupressure intervention integrated with spiritual coping skills has an effect on anxiety levels in CKD patients with hemodialysis through improving serotonin levels, and IgG
Method: This study uses Research and Development (R&D), the stages carried out in this study were stages one, two and three, namely: information gathering, product/model design, expert validation and revision. Samples were taken by purposive sampling technique, grouped into two, the first group was a sample of the information gathering stage, totaling 10, the second group was a sample of the expert validation stage, totaling 9 people consisting of specialist doctors, psychologists and religious leaders. Information collection data was tested using qualitative discriminatory and expert validation data was tested with intraclass correlation coefficient
Results: The results of gathering information concluded that the impact of hemodialysis treatment is the emergence of stress and anxiety in patients, anxiety, data can be overcome by acupressure treatment supported by activities that can meet psychological and religious/spiritual needs, thus providing a sense of comfort and increasing faith. Acupressure action with religious coping can reduce anxiety. Expert validation showed that the eligibility score was 90.9% with p=0.001 meaning that acupressure integrated spiritual coping skills was feasible as a model for reducing anxiety levels in patients with chronic kidney disease in the very feasible category.
Conclusion: The application of acupressure model integrated spiritual coping skills is feasible as a model to reduce anxiety levels in patients with chronic kidney disease on hemodialysis
Nursing Care for The Risk of Violent Behavior in Schizophrenic Patient
Authors: Ashari Harliyanti Nadiefa , Nur Rahmawati Arni , Adriani Prasati
Published: December 2022

Objective: This study aims to describe the nursing care of the risk of violent behavior in patients with schizophrenia in RSUD Banyumas.
Method: In this study, the researchers applied a case study method and the data collection techniques used were interviews, observations, and documentation studies.
Result: The results showed that after being given therapeutic communication for three days, the patients were able to control their emotions with assistance from the nurses and the patients seemed to be able to interact well.
Conclusion: Based on the results of the study, it can be concluded that nursing actions of deep breathing relaxation, and distraction by hitting the pillow can reduce the emotional problems of people with the risk of violent behavior.
Play Therapy with Digital Media Augmented Reality Cards to Improve Memory and Fine Motor Skills in Children
Authors: Hamdani Dadi , Firmansyah Andan , El Haque Iif Taufiq , Rahayu Gumelar Zati , Koswara Ade , Rahmat Akmal Rahayu Dasuki , Fadilah Alfi , Daffa Alifio Muhammad , Haekal Mohammad , Syahrul Zain Muhammad
Published: December 2022

Introduction: The development and support of digital technology have provided new opportunities to provide learning in the form of interesting educational games for early childhood. Because children are closely related to games, digital educational games are a strategic step to provide new experiences in learning, especially to improve children's memory and fine motor skills.
Purpose: The purpose of this community service is to carry out play therapy using card media with Augmented Reality which children have never done before.
Methods: Play therapy activities focused on school-age children are carried out by lecturers and a group of students from the D3 Nursing Study Program STIKes Muhammadiyah Ciamis. The method in play therapy activities uses simulation methods and direct practice in games using Augmented Reality card media. Location This service was held at SDN 1 Kalipucang Pangandaran with 20 students participating.
Results: This community service activity can illustrate how play therapy improves fine motor skills and memory in early childhood by using the Augmented Reality card approach that is displayed on the cellphone screen and changes from a 2-dimensional image to a 3-dimensional image. The children became very enthusiastic and became very curious about what kind of images would appear from the Augmented Reality cards they held. The overall age of children is (6-13 years) and in this game, they have memory and fine motor skills that are quite good according to their developmental age.
Conclusion: During the play therapy activities, it was successful and it was concluded that children were able to remember and know what type of cards and objects or creatures they were exploring with the help of a smartphone screen.
Upaya Peningkatan Pemahaman Pentingnya Imunisasi DPT pada Kader
Authors: Lestari Lusi , Heryani Heni , Nopianti Fitri , Nuraeni Fitri , Istikharoh  , Lestari Intan
Published: December 2022

Introduction: Efforts to reduce the level of morbidity and mortality in children, one of which is the provision of immunization. DPT immunization is one of the mandatory immunizations given to children which aims to generate active immunity against diphtheria, pertussis, and tetanus at the same time. In addition to having benefits, DPT immunization also causes side effects in its implementation which can cause anxiety in mothers so that they do not want their children to get DPT immunization. An understanding of the importance of immunization is needed to reduce anxiety and increase the coverage of DPT immunization.
Objective: The purpose of this health education is to increase understanding of the importance of DPT immunization for cadres
Method: The method used is health education about the importance of DPT immunization through lectures and discussions with leaflet media.
Result: The activity was carried out on Friday, September 23, 2022 at 13.00 WIB at the GOR Panykiran Village, Ciamis District. The total number of cadres who attended the health counseling activities was 30 people. The responses of the participants varied, but the majority were actively discussing.
Conclusion: This health education has been successful, it can be seen from the enthusiasm and enthusiasm of the cadres who play an active role in participating in the activities and can answer the evaluation of the material that has been delivered.
Kampanye No Drugs Untuk Mencegah Resiko Penularan HIV/AIDS
Authors: Nurapandi Adi , Nur Faridah Intan , Zaenal Mutaqin Dandi , Nurinayyah Irma , Ningsih Deti Martia , Hanief Assifa Picki , Rana  , Dzulfikar Moh. Akmal , Taufiq El Haque Iif
Published: December 2022

Introduction: Drug abuse is closely related to crime, traffic accidents and is currently at the stage of transmission of the HIV/AIDS virus. The sharp increase in HIV prevalence among injecting drug users is caused by the use of unsterile needles and syringes coupled with the practice of group injection. Various efforts to control and prevent drugs and HIV/AIDS have been carried out, one of which is to empower the potential and knowledge of youth through youth organizations.
Objective: to implement and increase knowledge to be directly and actively involved in the prevention of drug abuse and eradication in order to avoid and prevent the risk of HIV-AIDS transmission.
Method: The methodology used is that this consultation is based on strategy, implementation and action, and ends with an assessment conducted at the end of the update, using the number of surveys available to the community according to the required survey needs.
Result: The implementation of socialization of the dangers of drugs and the risk of HIV-AIDS to Wibawa Mukti youth organizations in Ciharalang village gave significant results because increasing youth knowledge about the dangers of injecting drugs has a role in encouraging the participation of all elements of the local community to avoid drug use.
Conclussion: The implementation of socialization of the dangers of drugs and the risk of hiv-aids to youth youth organizations in the village of ciharalang gave significant results because increasing youth knowledge about the dangers of injecting drug abuse has a role in encouraging the participation of all elements of the local community to avoid drug use.
Multidimensional Gas Chromatography Moves Forward
Authors: Cordero Chiara , Birch Carlo
Published: December 2022

In this extended special feature to celebrate the 35th anniversary edition of LCGC Europe, leading figures from the separation science community explore contemporary trends in separation science and identify possible future developments.
Nontargeted Screening in Environmental Analysis: An Example Showing Migration of Chemicals from Reusable Sports Plastic Bottles into Drinking Water
Authors: Tisler Selina , Christensen Jan H.
Published: December 2022

In this extended special feature to celebrate the 35th anniversary edition of LCGC Europe, leading figures from the separation science community explore contemporary trends in separation science and identify possible future developments.
The Paradox of Sustainability in Separation Science
Authors: Ferguson Paul
Published: December 2022

In this extended special feature to celebrate the 35th anniversary edition of LCGC Europe, leading figures from the separation science community explore contemporary trends in separation science and identify possible future developments.
Graph Neural Networks for Improved Retention Time Predictions
Authors: Kensert Alexander , Desmet Gert , Cabooter Deirdre
Published: December 2022

In this extended special feature to celebrate the 35th anniversary edition of LCGC Europe, leading figures from the separation science community explore contemporary trends in separation science and identify possible future developments.
How Mature is Gas Chromatography? An Industry Perspective
Authors: David Frank , Sandra Pat
Published: December 2022

In this extended special feature to celebrate the 35th anniversary edition of LCGC Europe, leading figures from the separation science community explore contemporary trends in separation science and identify possible future developments.
Drug Development Process: Nonclinical Development of Small-Molecule Drugs
Authors: Dong Michael W.
Published: December 2022

This article provides a high-level overview of the drug development process of small-molecule drugs for the analytical chemist. Emphasis is given to the nonclinical development and roles of the technical development organization in driving the new drug development project from toxicology studies to new product registration. A case study of the career path of a separation scientist is used to illustrate the diversified roles of an analytical chemist in drug development.
Terahertz Spectroscopic Analysis of Co-Crystallized Mixtures in an L-threonine Diastereomer System
Authors: Zeng Ruonan , Bian Yujing , Zhang Xun , Zhu Zhenqi , Yang Bin
Published: December 2022

Terahertz (THz) resonance absorption originates from intermolecular interactions, which are suitable for identifying amino acids with multiple isomers. L-threonine and L-allo-threonine are diastereomers with two characteristic peaks in the effective spectrum range of 1.0–2.3 THz, which are located at 1.42 and 2.14 THz for L-threonine (L-thr) and 1.63 and 2.16 THz for L-allo-threonine (L-allo-thr). Based on the density functional theory (DFT) of the crystal structures of L-thr and L-allo-thr, the vibration frequencies of 1.56, 1.87, 2.16 THz, and 2.22 THz were obtained, corresponding to the THz characteristic peaks. Through vibration model analysis, it was found that lattice and skeleton vibrations mediated by intermolecular hydrogen bonds play a crucial role in the THz response. Studying the experimental absorption spectra of different proportions co-crystallized mixtures and 1:1 physical mixture of L-thr and L-allo-thr, it was found that the characteristic peaks of the physical mixture include the characteristic peaks of the two diastereomers in the THz band, while amino-acid co-crystallized mixtures formed their own characteristic peaks depending on the proportion. The results show that the co-crystallized mixture composition of diastereomers can be quantitatively analyzed by THz time-domain spectroscopy (THz-TDS).
PHÂN TÍCH DANH MỤC THUỐC SỬ DỤNG TẠI BỆNH VIỆN ĐA KHOA TỈNH QUẢNG NINH NĂM 2021
Authors: Nguyễn Tuấn Quang , Nguyễn Cẩm Vân , Nguyễn Minh Thông , Đàm Thị Lâm
Published: December 2022

Mục tiêu: Phân tích cơ cấu và phân tích theo phân loại ABC/VEN danh mục thuốc (DMT) sử dụng tại Bệnh viện đa khoa (BVĐK) tỉnh Quảng Ninh năm 2021. Đối tượng và phương pháp: Nghiên cứu mô tả hồi cứu DMT sử dụng tại Bệnh viện từ ngày 01/01 - 31/12/2021. Kết quả: DMT sử dụng tại Bệnh viện năm 2021 có tổng giá trị > 98,5 tỷ đồng. Thuốc hóa dược chiếm 89,29% về số khoản mục và 99,06% về giá trị. Thuốc sản xuất trong nước chiếm 48,91% về số khoản mục và 38,37% về giá trị. Thuốc biệt dược gốc chiếm tỷ lệ 16,71% về số khoản mục và 23,81% về giá trị. Thuốc đơn thành phần chiếm 82,93% về số khoản mục và 77,72% về giá trị. Thuốc đường uống chiếm 48,18% về số khoản mục và 29,55% về giá trị. Các thuốc nhóm A, B, C chiếm tỷ lệ về số khoản mục và giá trị tương ứng là 15,38%, 19,98%, 64,64% và 79,82%, 15,15%, 5,03%. Các thuốc nhóm V, E, N chiếm tỷ lệ về số khoản mục và giá trị tương ứng là 14,04%, 62,47%, 23,49% và 15,81%, 69,99%, 14,20%. Các thuốc nhóm I, II, III chiếm tỷ lệ về số khoản mục và giá trị tương ứng là 27,12%, 57,99%, 14,89% và 83,21%, 15,28%, 1,51%. Kết luận: Phân tích được cơ cấu và phân tích theo phân loại ABC/VEN DMT sử dụng tại BVĐK tỉnh Quảng Ninh năm 2021.
FUNCTIONAL OUTCOMES AFTER SURGICAL TREATMENT OF PROXIMAL FEMUR FRACTURE IN ELDERLY PATIENTS
Authors: Hoàng Thế Hùng , Nguyễn Trường Giang , Nguyễn Lĩnh Toàn , Vũ Nhất Định , Phạm Đăng Ninh
Published: December 2022

Objectives: To evaluate the functional outcomes of surgical treatment for proximal femoral fractures. Subjects and methods: This prospective study included 89 cases with proximal fractures of the femur in whom locking plate fixation, or bipolar head arthroplasty was performed between April 2020 and January 2021 at the Orthopedic and Trauma Center, Military Hospital 103. Results: The median age of all patients was 76.42 years (range, 60 - 93 years). The number of proximal femoral fractures that occurred in females (61.8%) was more than in males (38.2%), with p < 0.001. The average surgical delay was 6.39 ± 4.18 days. The mean hospital stay time was 10.58 ± 5.622. There were (6.7%) deaths at the twelve-month follow-up, 14 (15.7%) with complications. The Barthel index score at 12 months was less than prior to fracture (90.42 vs. 98.49 points) (p < 0.001). The number of patients who have recovered from complications was less than those without complications (75% and 94%, respectively, p < 0.001). Recovery rate in the age groups 60 - 69 was reported as 98.6% and 71.61% over 90 years of age Conclusion: The Barthel index is a good tool to evaluate the physical recovery of pre-fracture condition and allows for the assessment of the functional recovery after one-year follow-up.
NGHIÊN CỨU ĐẶC ĐIỂM HÌNH ẢNH SIÊU ÂM NỘI SOI Ở BỆNH NHÂN UNG THƯ THỰC QUẢN
Authors: Lê Đặng Thành Công , Hoàng Đình Anh , Nguyễn Xuân Khái
Published: December 2022

Đặt vấn đề: Siêu âm nội soi (SÂNS) là một trong các phương pháp chẩn đoán sớm, chính xác ung thư thực quản (UTTQ) về giai đoạn bệnh và tiên lượng, góp phần quan trọng trong định hướng điều trị. Mục tiêu: Mô tả đặc điểm hình ảnh SÂNS ở bệnh nhân (BN) UTTQ và khảo sát mối liên quan một số đặc điểm hình ảnh SÂNS với các đặc điểm lâm sàng, hình ảnh nội soi, cắt lớp vi tính (CLVT) và mô bệnh học. Đối tượng và phương pháp: Nghiên cứu mô tả cắt ngang có phân tích, hồi cứu và tiến cứu, được tiến hành trên 40 BN được chẩn đoán UTTQ dựa trên kết quả mô bệnh học và SÂNS. Kết quả: Trong số 40 đối tượng nghiên cứu, UTTQ hay gặp ở 1/3 giữa chiếm 50%, 1/3 dưới chiếm 37,5% và 1/3 trên chiếm 12,5%. Tổn thương trên SÂNS chủ yếu là giảm âm với 85%, 15% là tăng âm và hỗn hợp âm. Giá trị đo lường tương đồng giữa SÂNS và chụp CLVT trong chẩn đoán giai đoạn khối u là yếu (Kappa = 0,296), chẩn đoán hạch di căn (Kappa = 0,396), chẩn đoán UTTQ theo phân loại TNM/ AJCC7 (Kappa = 0,355). Kết luận: SÂNS đóng vai trò quan trọng trong chẩn đoán giai đoạn bệnh, tuy nhiên cần phối hợp nhiều phương pháp chẩn đoán hình ảnh trong chẩn đoán giai đoạn UTTQ trước điều trị.
NGHIÊN CỨU ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG CỦA BỆNH NHÂN UNG THƯ BÀNG QUANG ĐƯỢC ĐIỀU TRỊ TẠI BỆNH VIỆN ĐA KHOA XANH PÔN
Authors: Nguyen Minh An , Ngô Trung Kiên
Published: December 2022

Mục tiêu: Nghiên cứu đặc điểm lâm sàng, cận lâm sàng của bệnh nhân (BN) ung thư bàng quang (UTBQ). Đối tượng và phương pháp: Nghiên cứu mô tả cắt ngang hồi cứu kết hợp tiến cứu trên 35 BN UTBQ được khám và điều trị tại Bệnh viện Đa khoa Xanh Pôn. Kết quả: Tuổi trung bình của BN là 58,7 ± 8,2 tuổi; tỷ lệ nam giới/nữ giới là 7,75/1. Lý do chính vào viện: Tiểu máu chiếm 97,1%; thời gian mắc bệnh trung bình là 3,9 ± 2,5 tháng; số lượng u trên phim chụp cắt lớp vi tính: 1 u chiếm 77,1%, 2 u chiếm 14,3%, 3 u chiếm 8,6%; kích thước u: < 3 cm chiếm 71,4% và ≥ 3 cm chiếm 28,6%; vị trí u qua soi bàng quang: Thành trước chiếm 20%, thành sau chiếm 8,6%, hai thành bên chiếm 51,4%, rải rác trong bàng quang chiếm 20%. Kết luận: Kết quả nghiên cứu cho thấy tiểu máu là triệu chứng thường gặp nhất (97,1%), 1 u chiếm tỷ lệ cao nhất (77,1%).
ĐÁNH GIÁ KẾT QUẢ ĐIỀU TRỊ KHÔNG PHẪU THUẬT Ở BỆNH NHÂN BONG GÂN KHỚP CỔ CHÂN TẠI BỆNH VIỆN DÃ CHIẾN CẤP 2 VIỆT NAM - NAM XU ĐĂNG
Authors: Lê Quang Đạo , Vũ Minh Dương , Nguyễn Bá Ngọc , Lê Việt Anh
Published: December 2022

Đặt vấn đề: Bong gân khớp cổ chân là tình trạng tổn thương phức hợp dây chằng bên của khớp cổ chân. Tổn thương được điều trị bằng cách bất động; điều trị không phẫu thuật và can thiệp phẫu thuật. Bong gân khớp cổ chân chiếm tỷ lệ cao trong số các mặt bệnh chấn thương điều trị tại Bệnh viện Dã chiến cấp 2 Việt Nam. Mục tiêu: Đánh giá hiệu quả của điều trị không phẫu thuật trong xử trí bong gân khớp cổ chân. Đối tượng và phương pháp: Nghiên cứu mô tả cắt ngang không đối chứng trên 42 bệnh nhân (BN) được điều trị tại Bệnh viện Dã chiến cấp 2 Việt Nam tại Bentiu, Nam Xu Đăng với chẩn đoán bong gân khớp cổ chân một bên. Các BN được chẩn đoán dựa trên thăm khám lâm sàng và chụp X-quang khớp cổ chân. Khám khớp cổ chân được khám lại 5 ngày sau khi bị thương. BN bong gân độ I không được đưa vào nghiên cứu. Tất cả BN bong gân khớp cổ chân độ II và III đều được điều trị không phẫu thuật. Kết quả: Trong số 42 BN, có 30 BN (71,4%) là nam giới và 12 BN (28,6%) là nữ giới; Độ tuổi từ 24 - 45, tuổi trung bình 31 ± 2,4. 34 BN (80,9%) được chẩn đoán là bong gân độ II và 8 BN (19,1%) bong gân độ III. Khi bắt đầu điều trị, các trường hợp đều đau dữ dội (VAS: 8 - 10), cử động khớp cổ chân bị hạn chế và đau. Thử nghiệm ngăn kéo trước dương tính ở 8 BN (19,1%). Vào cuối tuần điều trị thứ 8 có 38/42 BN (90,5%) hết đau, không sưng nề, vận động khớp cổ chân không hạn chế, đạt sự hài lòng tối đa. Ở tuần thứ 12, 100% BN hồi phục hoàn toàn và rất hài lòng với việc điều trị. Kết luận: Đối với bong gân khớp cổ chân độ II và III, điều trị không phẫu thuật tại Bệnh viện Dã chiến cấp 2 Việt Nam giúp BN phục hồi sớm và đạt kết quả tốt.
Evaluación de programas, el camino hacia la calidad educativa
Authors: Parra Peralta Patricia , Royet Rodríguez Henry , Vásquez Cuevas Yolman
Published: December 2022

Este documento corresponde a un artículo de reflexión que está pensado en presentar la evaluación de los programas educativos de instituciones educativas de América Latina y la región como una herramienta básica para alcanzar la calidad de la educación tan anhelada debdo a los bajos resultados obtenidos por nuestros sistemas educativos en las pruebas censales como PISA y Saber, en el caso de Colombia. La era del conocimiento, como se le ha llamado al movimiento apresurado de los avances tecnológicos, técnicos y científicos que demanda nuestra sociedad, trae consigo una serie de recursos nunca vistos para la circulación y almacenamiento de la información, al punto que se necesita una sociedad que sea capaz de administrarlas. Saber qué, cómo y quién lo hace es lo que atañe a las instituciones educativas; la formación brindada a la sociedad requiere involucramiento de todos los entes de la sociedad, se necesitan recursos de todo tipo para saber decidir cómo y qué programas ofrecer a la gente, conocimientos teóricos adaptados a la civilización, y es la evaluación continua, crítica y detallada la que puede garantizar las bases de las competencias del futuro ya presente. Este artículo contiene información relacionada con las distintas perspectivas, que, a través de la historia, dan fundamentación efectiva y acertada de los tipos y modelos de evaluación de programas de educación.
Studi Karakteristik Limpasan Gelombang Overtopping pada Struktur Tanggul Laut
Authors: Bong Novandy , Oki Setyandito  , Andrew John Pierre
Published: December 2022

Tanggul laut merupakan salah satu struktur bangunan pelindung pantai dari serangan gelombang. Berdasarkan studi terdahulu, salah satu faktor yang menyebabkan kerusakan tanggul laut adalah gelombang yang melimpas pada tanggul laut (wave overtopping). Aliran yang terjadi di atas tanggul laut akibat variasi gelombang dan runup gelombang dapat menyebabkan ketidakstabilan struktur. Pada naskah hasil penelitian ini, disajikan hasil studi karakteristik gelombang dan aliran yang melimpas di atas tanggul laut dengan variasi gelombang datang dan sudut kemiringan struktur. Penelitian ini dilakukan dengan pemodelan uji numerik model tanggul laut dengan metode komputasi dinamika fluida (computational fluid dynamics) melalui perangkat lunak FLOW-3D. Hasil penelitian ini menunjukkan bahwa perubahan karakteristik gelombang pada variasi struktur tanggul laut dipengaruhi oleh volume aliran gelombang yang melimpas dan nilai bilangan Iribarren.
La educación superior en el contexto de la innovación
Authors: Rodríguez-Bustamante Alexander , Rincon Barreto Dubis Marcela , Restrepo Gómez Katerine , Agudelo Torres José Federico
Published: December 2022

El artículo resulta de la reflexión acerca de la tendencia en los sistemas educativos hacia la generación de procesos de innovación y el papel de los protagonistas-participantes académicos en el acto educativo que se circunscribe a una modernidad posible para la acción y la transformación. El objetivo de este texto es generar la reflexión abierta entre la Educación Superior contextualizada con la innovación, como provocación inicial en tiempos de una escuela que posibilite la conversación, la creatividad, en suma: el encuentro. Para la discusión fue necesario asumir una postura sobre los conceptos de educación, educación superior, innovación e innovación disruptiva, lo que implicó el salto paradigmático hacia una educación-otra; se presentan algunos elementos diferenciadores entre educación y aprendizaje. Como conclusión se deja abierta la discusión frente la capacidad de la educación superior para asumirse en la relación dialéctica educación-innovación en el contexto de la sociedad moderna y sus consecuentes puntos de encuentro.
trabajo docente en primarias indígenas multigrado de Baja California durante el cierre de escuelas por el COVID-19
Authors: Delgado Gastelum Glenda , Tinajero Villavicencio María Guadalupe
Published: December 2022

Objetivo. Explorar el trabajo docente impulsado por el total de maestros de escuelas primaria indígenas multigrado de un estado del noroeste de México durante el cierre de escuelas, provocado por la emergencia sanitaria producto de la COVID-19. Diseño/Metodología/Enfoque. La investigación fue no experimental de corte transversal con un diseño censal. El instrumento fue un cuestionario que recabó información sobre los maestros, sus alumnos y las actividades que desarrollaron cotidianamente. Resultados/Discusión. Uno de los hallazgos más importantes fue el que los docentes de las escuelas indígenas multigrado hayan instrumentado la educación domiciliaria con la finalidad de mantener escolarizados a sus alumnos. Conclusiones. En el trabajo docente prevalecen prácticas dirigidas hacia la integración de estudiantes diversos por sus condiciones socioculturales, económicas e intelectuales.