bluuebunny/crossref_metadata_2025 huggingface dataset:
First Stabilization of 14‐Electron Rhodium(I) Complexes by Hemichelation
Authors: Werlé Christophe , Bailly Corinne , Karmazin‐Brelot Lydia , Le Goff Xavier‐Frédéric , Pfeffer Michel , Djukic Jean‐Pierre
Published: July 2014

Hemichelation is emerging as a new mode of coordination where non‐covalent interactions crucially contribute to the cohesion of electron‐unsaturated organometallic complexes. This study discloses an unprecedented demonstration of this concept to a Group 9 metal, that is, RhI. The syntheses of new 14‐electron RhIcomplexes were achieved by choosing theanti‐[(η6:η6‐fluorenyl){Cr(CO)3}2] anion as the ambiphilic hemichelating ligand, which was treated with [{Rh(nbd)Cl}2] (nbd=norbornadiene) and [{Rh(CO)2Cl}2]. The new T‐shaped RhIhemichelates were characterized by analytical and structural methods. Investigations using the methods of the DFT and electron‐density topology analysis (NCI region analysis, QTAIM theory) confirmed the closed‐shell, non‐covalent and attractive characters of the interaction between the RhIcenter and the proximal Cr(CO)3moiety. This study shows that, by appropriate tuning of the electronic properties of the ambiphilic ligand, truly coordination‐unsaturated RhIcomplexes can be synthesized in a manageable form.
Highly Efficient “On Water” Catalyst‐Free Nucleophilic Addition Reactions Using Difluoroenoxysilanes: Dramatic Fluorine Effects
Authors: Yu Jin‐Sheng , Liu Yun‐Lin , Tang Jing , Wang Xin , Zhou Jian
Published: July 2014

A remarkable fluorine effect on “on water” reactions is reported. The CF⋅⋅⋅HO interactions between suitably fluorinated nucleophiles and the hydrogen‐bond network at the phase boundary of oil droplets enable the formation of a unique microstructure to facilitate on water catalyst‐free reactions, which are difficult to realize using nonfluorinated substrates. Accordingly, a highly efficient on water, catalyst‐free reaction of difluoroenoxysilanes with aldehydes, activated ketones, and isatylidene malononitriles was developed, thus leading to the highly efficient synthesis of a variety of α,α‐difluoro‐β‐hydroxy ketones and quaternary oxindoles.
Preparation and characterization of high‐selectivity hollow fiber composite nanofiltration membrane by two‐way coating technique
Authors: Li Hongbin , Wang Wei , Zhang Yufeng
Published: July 2014

A novel coating technique, named as two‐way coating (TWC), was explored to prepare hollow fiber composite (HFC) nanofiltration (NF) membrane through interfacial polymerization from piperazine (PIP) and trimesoyl chloride (TMC) on the lumen side of hollow fiber polysulfone ultrafiltration membrane with an effective membrane area of 0.4 m2. The optimum preparation conditions were systematically investigated and obtained as follows: PIP 0.023 mol/L, TMC 0.0057 mol/L, air blowing rate 2.7 m/s for 30 min after aqueous coating, aqueous coating pressure 0.1 MPa, organic solution flowing rate 0.32 m/s, and heat treating time 3 min. The resultant HFC membrane showed a high selectivity of divalent ion and monovalent ion. Salt rejections of MgSO4 and NaCl were 98.13 and 18.6% with the permeate flux of 32.6 and 40.2 L m−2 h−1 at 0.7 MPa, respectively. Field emission scanning electron microscopy images indicated that composite membrane prepared by TWC technique had a uniform active layer from the upper end to the bottom of the hollow fiber. And the salt rejection and permeate flux showed almost no difference between different membrane sections. Stability results suggested that good reproducibility could be obtained by TWC technique for the preparation of high‐performance HFC NF membrane. The resultant NF membrane showed a high removal rate of chemical oxygen demand and chroma of landfill leachate which were approximately 100%. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 41187.
Crumb tire rubber and polyethylene mutually stabilized in asphalt by screw extrusion
Authors: Wang Shifeng , Yuan Conghui , Jiaxi Deng
Published: July 2014

In order to put recycled rubber and plastics into practical use for asphalt's modification, the polyethylene (PE)/crumb tire rubber (CTR) blends were blended to prevent them from phase separation in asphalt during hot storage. The effect of screw extrusion on storage stability, morphology, and thermal properties of modified asphalt were investigated. The results showed that the storage stability of PE/CTR modified asphalt was significantly improved after screw extrusion in the presence of a compatibilizer. The extruded PE and CTR were more finely and uniformly dispersed in the asphalt. The rheological properties of modified asphalts were improved at both higher and lower temperature's range. The density discrepancy between asphalt and the extruded PE/CTR particles was neutralized by the combination between PE and CTR. The interactions among PE, CTR and asphalt were improved by the compatibilizer. Both the reduction of density difference and the enhanced interactions are critical to obtain a stable modified asphalt system. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 41189.
Effect of charring agent THEIC on flame retardant properties of polypropylene
Authors: Chen Wenyan , Yuan Shanshan , Sheng Yong , Liu Gousheng
Published: July 2014

Tris(2‐hydroxyethyl) isocyanurate (THEIC) was used as charring agent and combined with ammonium polyphosphate (APP) to form an intumescent flame retardant (IFR) for polypropylene (PP). The flame retardancy and combustion performance of PP/IFR composite was tested by limiting oxygen index (LOI), UL‐94 vertical burning test and cone calorimeter. The results showed that PP/IFR composite had highest LOI of 34.8 and obtained V‐0 rating when 30 wt % IFR was loaded and mass ratio APP/THEIC was 2 : 1. The peak heat release (PHRR) and total heat release (THR) values of PP composite containing FRs were remarkably reduced compared with that of pure PP. However, water resistant test demonstrated the PP/IFR composite had poor flame retardant durability, both the LOI value and UL‐94 V‐rating decreased when PP/IFR composite was soaked in water at 70°C after 36 h. The degradation process and the char morphology of IFR and PP/IFR composite were investigated by TGA and SEM images. The possible reaction path between APP and THEIC in the swollen process was proposed. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41214.
Inhibition of JNK3 Promotes Apoptosis Induced by BH3 Mimetic S1 in Chemoresistant Human Ovarian Cancer Cells
Authors: Yang Xiaochun , Xiang Xiyan , Xia Meihui , Su Jing , Wu Yao , Shen Luyan , Xu Ye , Sun Liankun
Published: July 2014

Previous studies have suggested that the novel BH3 mimetic S1 could induce apoptosis in diverse tumor cell lines through endoplasmic reticulum (ER) stress or mitochondrial cell death pathways. The activation of c‐Jun N‐terminal kinase (JNK) through inositol requiring enzyme‐1 (IRE1) is closely connected to ER stress‐induced apoptosis. However, the role of JNK is complex, as there are different JNK subtypes and the function of each subtype is still not entirely clear. Here we found that the mRNA expression of JNK3 was continuously high in S1‐treated human ovarian cancer SKOV3/DDP cells using a human unfolded protein response (UPR) pathway PCR array. Pharmacological inhibition of JNK3 increased cell sensitivity to apoptosis induced by S1. Furthermore, inhibition of JNK3 induced accumulation of both acidic compartment and p62, and upregulated ROS production. Our results suggest that JNK3 plays a pro‐survival role during ER stress through preventing the block of autophagic flux and reducing oxidative stress in SKOV3/DDP cells. Inhibition of JNK3 may be a potential method to enhance the killing effect of the Bcl‐2 inhibitor S1. Anat Rec, 298:386–395, 2015. © 2014 Wiley Periodicals, Inc.
Improvement of trospium‐specific absorption models for fasted and fed states in humans
Authors: Cvijić Sandra , Langguth Peter
Published: July 2014

The purpose of this study was to mechanistically interpret the oral absorption pattern of trospium in fasted and fed states by means of gastrointestinal simulation technology. A drug absorption model was built on the basis of experimental data. According to the generated model, low permeability across the intestinal epithelium, delayed gastric emptying time and a prolonged residence time in the small intestine are the key factors governing trospium absorption in the fasted state. Furthermore, in silico modelling provided a plausible explanation of the pronounced reduction in the oral bioavailability of trospium when administered with food. The simulation results support the decreased dissolution in viscous medium, and the reduced drug permeability in the fed state as the predominant mechanisms for the food effect on trospium absorption. Copyright © 2014 John Wiley & Sons, Ltd.
Population pharmacokinetics of the 11β‐hydroxysteroid dehydrogenase type 1 inhibitor ABT‐384 in healthy volunteers following single and multiple dose regimens
Authors: An Guohua , Liu Wei , Katz David A. , Marek Gerard J. , Awni Walid , Dutta Sandeep
Published: July 2014

ABT‐384 is a potent and selective inhibitor of 11β‐hydroxysteroid dehydrogenase type 1 (HSD‐1). The pharmacokinetics of ABT‐384 was evaluated in healthy volunteers in single‐dose (1, 8, 20, 50, 120 and 240 mg) and multiple‐dose studies (1, 2, 4, 8, 20, 30 and 100 mg once daily). Less than dose‐proportional pharmacokinetics of ABT‐384 was observed when ABT‐384 was administered at single doses lower than 8 mg. This nonlinear phenomenon disappeared after repeated doses. The dose‐normalized plasma concentration–time curves superposed across all dose groups on day 7, but not on day 1. This phenomenon cannot be explained by the half‐life of ABT‐384. Based on available data, the nonlinearity is likely due to binding of ABT‐384 to a high‐affinity‐low‐capacity site, such that this interaction was reflected in ABT‐384 pharmacokinetics. To characterize the pharmacokinetics of ABT‐384, a population pharmacokinetic model for ABT‐384 was constructed. The model provided reasonable fitting for both single‐ and multiple‐dose data. Further investigation is warranted to evaluate the disposition of ABT‐384 at low doses using a larger number of subjects. The constructed model would be useful in predicting ABT‐384 concentrations at different doses and guiding the selection of dosing regimens in further clinical trials. Copyright © 2014 John Wiley & Sons, Ltd.
Etienne‐Arthur Louis Fallot and his tetralogy
Authors: Loukas Marios , Cesmebasi Alper , Le Duong , Etienne Denzil , Tubbs R. Shane , Anderson Robert H.
Published: July 2014

Étienne‐Arthur Louis Fallot (1850–1911) is one of the most significant medical figures of the 19th century with an eponymous congenital cardiac malformation. His initial account of the four anatomical features making up his tetralogy proved remarkably significant in the progression of clinical descriptions of the lesions producing cyanotic congenital cardiac disease. Although subsequently the cause of appreciable controversy, the accuracy of his initial descriptions underscore the current diagnostic and therapeutic approach to the malformation now known uniformly as tetralogy of Fallot. Clin. Anat. 27:958–963, 2014. © 2014 Wiley Periodicals, Inc.
Synthesis of the Human Milk Oligosaccharide Lacto‐N‐Tetraose in Metabolically Engineered, Plasmid‐Free E. coli
Authors: Baumgärtner Florian , Conrad Jürgen , Sprenger Georg A. , Albermann Christoph
Published: July 2014

Human milk oligosaccharides (HMOs) constitute the third most abundant solid component of human milk. HMOs have been demonstrated to show positive effects on the infant’s well‐being. Despite numerous studies, more physiological analyses of single compounds are needed to fully elucidate these effects. Although being one of the most abundant core structures in human milk, the HMO lacto‐N‐tetraose (LNT) is not available at reasonable prices. In this study, we demonstrate the construction of the first E. coli strain capable of producing LNT in vivo. The strain was constructed by chromosomally integrating the genes lgtA and wbgO, encoding β‐1,3‐N‐acetylglucosaminyltransferase and β‐1,3‐galactosyltransferase. In shake‐flask cultivations, the strain yielded a total concentration of 219.1±3.5 mg L−1 LNT (LNT in culture broth and the cell pellet). After recovery of LNT, structural analysis by NMR spectroscopy confirmed the molecule structure.
HAb18G/CD147 is involved in TGF‐β‐induced epithelial‐mesenchymal transition and hepatocellular carcinoma invasion
Authors: Ru Ning‐Yu , Wu Jiao , Chen Zhi‐Nan , Bian Huijie
Published: July 2014

Epithelial‐mesenchymal transition (EMT) induced by the transforming growth factor beta (TGF‐β) is involved in hepatocarcinogenesis and hepatocellular carcinoma (HCC) metastasis. HAb18G/CD147, a member of the immunoglobulin family, plays an important role in tumor invasion and metastasis. HAb18G/CD147 promotes EMT of hepatocytes through TGF‐β signaling and is transcriptionally regulated by Slug. We investigated the role of HAb18G/CD147 in TGF‐β‐induced EMT in HCC invasion. Two human HCC cell lines, SMMC‐7721 and HepG2, were used to determine the role of HAb18G/CD147 in EMT. Upregulation of HAb18G/CD147 induced by the high doses of TGF‐β1 in SMMC‐7721 (5 ng/mL) and HepG2 cells (10 ng/mL) (P < 0.05). CD147 upregulation was coupled with upregulation of Snail1 and Slug. CD147 knockout significantly decreased the expression of N‐cadherin and vimentin, and colony formation ability of SMMC‐7721 cells. TGF‐β1 enhanced the migration capacity of SMMC‐7721 cells, which was markedly attenuated by CD147 knockdown. Thus, HAb18G/CD147 is involved in TGF‐β‐induced EMT and HCC invasion.
Incidence and timing of hypotension after transcervical carotid artery stenting: Correlation with postoperative complications
Authors: Cirbian Jesús , Echaniz Gastón , Gené Anna , Silva Lorena , Fernández‐Valenzuela Valentín , de Nadal Miriam
Published: July 2014

Objectives

To assess the incidence and timing of hypotension after carotid artery stenting (CAS) and its correlation with postoperative complications.

Background

CAS‐associated postoperative hypotension has been linked to surgical morbidity and mortality, especially to stroke and cardiac complications.

Methods

Ninety‐seven consecutive patients undergoing transcervical CAS were monitored for at least 12 hr after operation. Hypotension was defined as systolic blood pressure < 90 mm Hg. Patients were divided into three groups: normal blood pressure and early (≤6 hr) and late (>6 hr) hypotension. Complications were recorded.

Results

Hypotension occurred in 34% of the patients (early hypotension in 63% of them). Hypotension was recorded in 21.6% of patients during surgery and in 21.6%, 15.5%, and 1.0% at 6, 12, and 24 hr postoperatively. Bradycardia occurred in 26.8% during operation and in 25.8%, 13.4%, and 10.3% at 6, 12, and 24 hr after surgery. Intraoperative bradycardia (P = 0.01) and hypotension (P = 0.02) were predictors of postoperative hypotension. The overall rate of complications was 5% without differences between the study groups. The mean length of stay was 3, 3.6, and 2.8 days in the normotensive, early hypotension, and late hypotension groups, respectively.

Conclusions

Most postoperative hypotension episodes occurred within the first 6 hr, and more than one‐third between the 6 and 12 hr post‐procedure. All patients with late hypotension were asymptomatic. There was no difference in complications between the study groups. In patients undergoing ambulatory CAS, hemodynamic monitoring in the postoperative period is particularly important during the first 12 hr. © 2014 Wiley Periodicals, Inc.
Au/NiCo2O4 Arrays with High Activity for Water Oxidation
Authors: Liu Xijun , Liu Junfeng , Li Yaping , Li Yingjie , Sun Xiaoming
Published: July 2014

The oxygen evolution reaction (OER) is a critical step in water splitting to produce hydrogen. In this report, Au/NiCo2O4 nanorod arrays with high activity for OER have been fabricated by a facile hydrothermal method followed by a reduction process. The Au/NiCo2O4 nanoarrays exhibited OER activity that was almost four times higher than that of Ir/C (at 1.75 V vs. RHE), and a small Tafel slope (63 mV decade−1). Moreover, this Au/NiCo2O4 hybrid‐array electrode showed good stability in alkaline solution, which is required of an active anode for water electrolysis.
Direct C sp2H and C sp3H Arylation Enabled by Heterogeneous Palladium Catalysts
Authors: Djakovitch Laurent , Felpin François‐Xavier
Published: July 2014

This review gives an overview of direct CH arylation catalyzed by heterogeneous Pd catalysts. The efficiency of the different forms of heterogeneous Pd catalysts is discussed with a critical view of the transformations attainable. If experimental evidence is provided, mechanistic considerations on the true nature of the catalysis, that is, heterogeneous versus homogeneous, are discussed as well.
Magnetic Anisotropy of Mononuclear NiII Complexes: On the Importance of Structural Diversity and the Structural Distortions
Authors: Singh Saurabh Kumar , Gupta Tulika , Badkur Prashi , Rajaraman Gopalan
Published: July 2014

Mononuclear NiII complexes are particularly attractive in the area of single‐molecule magnets as the axial zero‐field splitting (D) for the NiII complexes is in the range of −200 to +200 cm−1. Despite this advantage, very little is known on the origin of anisotropy across various coordination ligands, coordination numbers, and particularly what factors influence the D parameter in these complexes. To answer some of these questions, herein we have undertaken a detailed study of a series of mononuclear NiII complexes with ab initio calculations. Our results demonstrate that three prominent spin‐conserved low‐lying d–d transitions contribute significantly to the D value. Variation in the sign and the magnitude of D values are found to correlate to the specific structural distortions. Apart from the metal–ligand bond lengths, two different parameters, namely, Δα and Δβ, which are correlated to the cis angles present in the coordination environment, are found to significantly influence the axial D values. Developed magneto–structural D correlations suggest that the D values can be enhanced significantly by fine tuning the structural distortion in the coordination environment. Calculations performed on a series of NiII models with coordination numbers two to six unfold an interesting observation—the D parameter increases significantly upon a reduction in coordination number compared with a reference octahedral coordination. Besides, if high symmetry is maintained, even larger coordination numbers yield large D values.
Fluorine as a Hydrogen‐Bond Acceptor: Experimental Evidence and Computational Calculations
Authors: Dalvit Claudio , Invernizzi Christian , Vulpetti Anna
Published: July 2014

Hydrogen‐bonding interactions play an important role in many chemical and biological systems. Fluorine acting as a hydrogen‐bond acceptor in intermolecular and intramolecular interactions has been the subject of many controversial discussions and there are different opinions about it. Recently, we have proposed a correlation between the propensity of fluorine to be involved in hydrogen bonds and its 19F NMR chemical shift. We now provide additional experimental and computational evidence for this correlation. The strength of hydrogen‐bond complexes involving the fluorine moieties CH2F, CHF2, and CF3 was measured and characterized in simple systems by using established and novel NMR methods and compared to the known hydrogen‐bond complex formed between acetophenone and p‐fluorophenol. Implications of these results for 19F NMR screening are analyzed in detail. Computed values of the molecular electrostatic potential at the different fluorine atoms and the analysis of the electron density topology at bond critical points correlate well with the NMR results.
Drastic Enhancement of Catalytic Activity via Post‐oxidation of a Porous MnII Triazolate Framework
Authors: Liao Pei‐Qin , Li Xu‐Yu , Bai Jie , He Chun‐Ting , Zhou Dong‐Dong , Zhang Wei‐Xiong , Zhang Jie‐Peng , Chen Xiao‐Ming
Published: July 2014

MnIII is a powerful active site for catalytic oxidation of alkyl aromatics, but it can be only stabilized by macrocyclic chelating ligands such porphyrinates. Herein, by using benzobistriazolate as a rigid bridging ligand, a porous MnII azolate framework with a nitrogen‐rich coordinated environment similar to that of metalloporphyrins was synthesized, in which the MnII ions can be post‐oxidized to MnIII to achieve drastic increase of catalytic (aerobic) oxidation performance.
Core–Shell NiFe2O4@TiO2 Nanorods: An Anode Material with Enhanced Electrochemical Performance for Lithium‐Ion Batteries
Authors: Huang Gang , Zhang Feifei , Du Xinchuan , Wang Jianwei , Yin Dongming , Wang Limin
Published: July 2014

Hierarchical porous core–shell NiFe2O4@TiO2 nanorods have been fabricated with the help of hydrothermal synthesis, chemical bath deposition, and a subsequent calcinating process. The nanorods with an average diameter of 48 nm and length of about 300–600 nm turn out have a highly uniform morphology and are composed of nanosized primary particles. Owing to the synergistic effect of individual constituents as well as the hierarchical porous structure, the novel core–shell NiFe2O4@TiO2 nanorods exhibit superior electrochemical performance when evaluated as anode materials for lithium‐ion batteries. At the current density of 100 mA g−1, the composite exhibits a reversible specific capacity of 1034 mAh g−1 up to 100 charge–discharge cycles, which is much higher than the uncoated NiFe2O4 nanorods. Even when cycled at 2000 mA g−1, the discharge capacity could still be maintained at 358 mAh g−1.
Carbolithiation of Chloro‐Substituted Alkynes: A New Access to Vinyl Carbenoids
Authors: Lhermet Rudy , Ahmad Maha , Fressigné Catherine , Silvi Bernard , Durandetti Muriel , Maddaluno Jacques
Published: July 2014

The intramolecular carbolithiation of a series of chloro‐substituted alkynes leads to exocyclic alkylidene carbenoids of which both nucleophilic and electrophilic characters can be drove. A sole stereoselective 5‐exo‐dig addition takes place, probably because of a strong and persisting Li–Cl interaction arising before the transition state.
ChemInform Abstract: 183W INADEQUATE 2D NMR Spectroscopy of Hetero Arsenato‐Phosphato‐Tungstate PV/AsV Substitution in Dawson‐Type α‐[AsxP2—xW18O62] 6‐ (x = 0—2) and α‐[H4AsyP1—yW18 O62]7‐ (y = 0, 1).
Authors: Haouas Mohamed , Mbomekalle Israel‐Martyr , Vila Neus , de Oliveira Pedro , Taulelle Francis
Published: July 2014

The Dawson‐type arsenato‐phosphato tungstates of title are investigated by 183W and 31P NMR spectroscopy.
ChemInform Abstract: Mg Dopant in Cu2ZnSnSe4: An n‐Type Former and a Promoter of Electrical Mobility up to 120 cm2 V‐1s‐1.
Authors: Kuo Dong‐Hau , Wubet Walelign
Published: July 2014

Bulk pellets of (Cu2‐xMgx)ZnSnSe4 (x = 0, 0.1, 0.2, 0.3, 0.4) are prepared by a two‐step liquid‐phase reactive sintering technique from mixtures of Cu2Se, ZnSe, SnSe2, and Mg using Sb2S3 and Te as sintering aids (600 °C for 2 h with a holding at 300 °C for 1 h).
ChemInform Abstract: Crystal and Electronic Structures and Magnetic Properties of Eu3Tt2As4 (Tt: Si, Ge).
Authors: Liu Xiao‐Cun , Xia Sheng‐Qing , Lei Xiao‐Wu , Pan Ming‐Yan , Tao Xu‐Tang
Published: July 2014

Eu3Si2As4 (I) is prepared from the elements in an Sb flux (Eu/Si/As = 5:2:6; 1.
ChemInform Abstract: A Novel Ternary Uranium‐Based Intermetallic U34Fe4‐xGe33: Structure and Physical Properties.
Authors: Henriques M. S. , Berthebaud D. , Waerenborgh J. C. , Lopes E. B. , Pasturel M. , Tougait O. , Goncalves A. P.
Published: July 2014

U34Fe4‐xGe33 is prepared by arc melting of the elements in the molar ratio U:Fe:Ge = 9:1:10.
ChemInform Abstract: New Members of Layered Oxychloride Perovskites with Square Planar Coordination: Sr2MO2Cl2 (M: Mn, Ni) and Ba2PdO2Cl2.
Authors: Tsujimoto Y. , Sathish C. I. , Matsushita Y. , Yamaura K. , Uchikoshi T.
Published: July 2014

Sr2MO2Cl2 (M: Mn, Ni) and Ba2PdO2Cl2 are prepared under high‐pressure high‐temperature conditions using stoichiometric amounts of SrO2, MnCl2, SrCl2, BaO, PdO, and BaCl2 (Pt capsule, 3 GPa, 1400 °C, 1 h; resp.
ChemInform Abstract: A Facile Method for the Synthesis of the Li0.3La0.57TiO3 Solid State Electrolyte.
Authors: Zhang Qifeng , Schmidt Nick , Lan Jolin , Kim Whungwhoe , Cao Guozhong
Published: July 2014

Li0.3La0.57TiO3 is prepared by forming a coagulated precursor solution with a highly homogeneous Li+, La3+, and TiO2 nanoparticle mixture by dispersing stoichiometric amounts of TiO2 in an aqueous LiO‐Ac/La(O‐Ac)3 solution followed by freeze drying the coagulate and heating at 750 °C for the removal of crystallization H2O and La/Li oxide formation.
ChemInform Abstract: Synthesis of α‐Dawson‐Type Silicotungstate [α‐Si2W18O62]8‐ and Protonation and Deprotonation Inside the Aperture Through Intramolecular Hydrogen Bonds.
Authors: Minato Takuo , Suzuki Kosuke , Kamata Keigo , Mizuno Noritaka
Published: July 2014

α‐Dawson‐type silicotungstates (III), (IV), and (V) are synthesized by dimerization of a trivacant lacunary α‐Keggin‐type silicotungstate (II) under mild conditions.
ChemInform Abstract: Novel Non‐magnetic Hard Boride Co5B16 Synthesized under High Pressure.
Authors: Bykova Elena , Tsirlin Alexander A. , Gou Huiyang , Dubrovinsky Leonid , Dubrovinskaia Natalia
Published: July 2014

Single crystals of Co5B16 are prepared from the elements in a Kawai‐type multi‐anvil apparatus (15 GPa, 1873—1573 K, 40 min).
ChemInform Abstract: Isothiourea‐Catalyzed Asymmetric Synthesis of β‐Lactams and β‐Amino Esters from Arylacetic Acid Derivatives and N‐Sulfonylaldimines.
Authors: Smith Siobhan R. , Douglas James , Prevet Hugues , Shapland Peter , Slawin Alexandra M. Z. , Smith Andrew D.
Published: July 2014

The isothioureas shown in the scheme efficiently promote the [2 + 2] cycloaddition of sulfonylaldimines to arylacetic acids and anhydrides as well as (phenylthio)acetic acid giving 3,4‐anti‐substituted β‐lactams with good to high stereoselectivity.
ChemInform Abstract: Asymmetric α‐Amination Reaction of Alkenyl Trifluoroacetates Catalyzed by a Chiral Phosphine—Silver Complex.
Authors: Yanagisawa Akira , Miyake Ryoji , Yoshida Kazuhiro
Published: July 2014

A novel catalytic asymmetric α‐amination of alkenyl trifluoroacetates is developed that allows the synthesis of various optically active α‐hydrazino ketones with enantioselectivities up to 97% e.e.
ChemInform Abstract: Asymmetric Synthesis of 2,5‐Disubstituted 3‐Hydroxypyrrolidines Based on Stereodivergent Intramolecular Iridium‐Catalyzed Allylic Aminations.
Authors: Natori Yoshihiro , Kikuchi Shunsuke , Kondo Takahiro , Saito Yukako , Yoshimura Yuichi , Takahata Hiroki
Published: July 2014

Intramolecular Ir‐catalyzed allylic amination of enantiopure (E)‐aminoheptenyl carbonates is investigated.
ChemInform Abstract: Enantioselective Oxidative‐Coupling of Polycyclic Phenols.
Authors: Takizawa Shinobu , Kodera Junpei , Yoshida Yasushi , Sako Makoto , Breukers Stefanie , Enders Dieter , Sasai Hiroaki
Published: July 2014

Axially chiral vanadium complexes catalyze the enantioselective oxidative‐coupling of polycyclic phenols to biphenols.
ChemInform Abstract: Allylic Functionalization of Unactivated Olefins with Grignard Reagents.
Authors: Bao Hongli , Bayeh Liela , Tambar Uttam K.
Published: July 2014

The coupling of unactivated olefins with a variety of Grignard reagents is achieved via conversion of the olefin to an allylic sulfinamide and subsequent addition of the Grignard compound.
ChemInform Abstract: PhI(OAc)2‐Mediated Radical Trifluoromethylation of Vinyl Azides with Me3SiCF3.
Authors: Wang Yi‐Feng , Lonca Geoffroy Herve , Chiba Shunsuke
Published: July 2014

An efficient radical trifluoromethylation of a variety of vinyl azides using Me3SiCF3 as CF3‐source and hypervalent iodine as promotor is presented.
ChemInform Abstract: Silver‐Catalyzed Cross‐Coupling of Propargylic Alcohols with Isocyanides: An Atom‐Economical Synthesis of 2,3‐Allenamides.
Authors: Liu Jianquan , Liu Zhenhua , Wu Nannan , Liao Peiqiu , Bi Xihe
Published: July 2014

An unprecedented silver‐catalyzed cross‐coupling reaction between propargylic alcohols and isocyanides is described.
ChemInform Abstract: Catalytic Enantioselective Amination of Alcohols by the Use of Borrowing Hydrogen Methodology: Cooperative Catalysis by Iridium and a Chiral Phosphoric Acid.
Authors: Zhang Yao , Lim Ching‐Si , Sim Derek Sui Boon , Pan Hui‐Jie , Zhao Yu
Published: July 2014

The first enantioselective amination of secondary alcohols with aromatic amines using a binary catalyst comprising a chiral Ir complex and a BINOL‐derived phosphoric acid is presented.
ChemInform Abstract: Direct α‐Alkylation of Ketones with Alcohols in Water.
Authors: Xu Guoqiang , Li Qiong , Feng Jiange , Liu Qiang , Zhang Zuojun , Wang Xicheng , Zhang Xiaoyun , Mu Xindong
Published: July 2014

A new and green C—C bond formation in water is developed.
ChemInform Abstract: Synthesis and Characterization of the 2‐Methylaminopyridine‐Functionalized Polystyrene Resin‐Supported Pd(II) Catalyst for the Mizoroki—Heck and Sonogashira Reactions in Water.
Authors: Bakherad Mohammad , Amin Amir Hosein , Gholipoor Farzaneh
Published: July 2014

The synthesis of the heterogeneous catalyst is described.
ChemInform Abstract: Regioselective C2 Sulfonylation of Indoles Mediated by Molecular Iodine.
Authors: Katrun Praewpan , Mueangkaew Charoensak , Pohmakotr Manat , Reutrakul Vichai , Jaipetch Thaworn , Soorukram Darunee , Kuhakarn Chutima
Published: July 2014

No product is obtained for the reaction of Tol‐SO2Na with N‐protected indoles, including N‐Cbz, N‐Bz, N‐Mes.
ChemInform Abstract: Conversion of Oxiranes and CO2 to Organic Cyclic Carbonates Using a Recyclable, Bifunctional Polystyrene‐Supported Organocatalyst.
Authors: Whiteoak Christopher J. , Henseler Andrea H. , Ayats Carles , Kleij Arjan W. , Pericas Miquel A.
Published: July 2014

Organocatalysts based on polystyrene‐supported pyrogallol are synthesized starting from azidomethyl polystyrene and used for title conversion to prepare cyclic carbonates [(III), (V), (VII), and (VIII)].
ChemInform Abstract: Antimycobacterial Evaluation of Novel Hybrid Arylidene Thiazolidine‐2,4‐diones.
Authors: Ponnuchamy Singanan , Kanchithalaivan Selvaraj , Ranjith Kumar Raju , Ashraf Ali Mohamed , Soo Choon Tan
Published: July 2014

17 Title compounds of type (V) are prepared and most of them show moderate to good antimycobacterial activity.
ChemInform Abstract: Copper(I) and Palladium Nanoparticles Supported on Ethylenediamine‐Functionalized Cellulose as an Efficient Catalyst for the 1,3‐Dipolar Cycloaddition/Direct Arylation Sequence.
Authors: Keshipour Sajjad , Shaabani Ahmad
Published: July 2014

The catalyst can be easily recovered by simple filtration and reused without loss of its activity for at least five cycles.
ChemInform Abstract: Pd/Ligand‐Free Synthesis of Thienopyranones via Cu‐Catalyzed Coupling‐Cyclization in PEG 400 under Ultrasound.
Authors: Rao Manam Sreenivasa , Haritha Meda , Chandrasekhar N. , Basaveswara Rao Mandava V. , Pal Manojit
Published: July 2014

A reaction mechanism for this inexpensive and easy thienopyranone synthesis is also proposed.
ChemInform Abstract: Synthesis and Reactions of Sulfur‐Substituted α,β‐Unsaturated δ‐ and γ‐Lactones.
Authors: Chou Shang‐Shing P. , Wu Wan‐Shiuan
Published: July 2014

The reaction of compounds like (I) with NaOH gives a new access to different lactones and it can be shown that the influence of the substituents at C5 and C6 are very important for the success of the reaction.
ChemInform Abstract: Heterogeneous Ditopic ZnFe2O4 Catalyzed Synthesis of 4H‐Pyrans: Further Conversion to 1,4‐DHPs and Report of Functional Group Interconversion from Amide to Ester.
Authors: Das Paramita , Dutta Arghya , Bhaumik Asim , Mukhopadhyay Chhanda
Published: July 2014

A variety of pyranes, e.g. compounds (III), (VI), (VIII), and (XIV), is readily prepared by ZnFe2O4‐catalyzed reactions in aqueous media.
ChemInform Abstract: Mild and Efficient One—Pot Synthesis of Diverse Flavanone Derivatives via an Organocatalyzed Mannich‐Type Reaction.
Authors: Vuppalapati Srinivasu V. N. , Xia Likai , Edayadulla Naushad , Lee Yong Rok
Published: July 2014

This method is successfully applied in the synthesis of naturally occurring flavanones (IIIa), (IIIc), and (XI).
ChemInform Abstract: One‐Pot Access to Pyridocoumarins via Povarov‐Hydrogen Transfer Cascade under Auto‐Tandem Catalysis of Iodine in Aqueous Micelles.
Authors: Ganguly Nemai C. , Chandra Sumanta
Published: July 2014

The conversion of the starting materials (I) and (VI) leads also to significant amounts of a Schiff′s base reduction product.
ChemInform Abstract: Silica‐Bonded N‐Propyl Sulfamic Acid as an Efficient Recyclable Catalyst for the Synthesis of 3,4‐Dihydropyrimidin‐2‐(1H)‐ones/thiones under Heterogeneous Conditions
Authors: Jetti Srinivasa Rao , Bhatewara Anjna , Kadre Tanuja , Jain Shubha
Published: July 2014

using a one‐pot three‐component Biginelli condensation reaction
ChemInform Abstract: One‐Pot Synthesis of 2‐Substituted Quinoxalines Using K10‐Montmorillonite as Heterogeneous Catalyst.
Authors: Jeganathan Mariappan , Dhakshinamoorthy Amarajothi , Pitchumani Kasi
Published: July 2014

A reaction mechanism of the montmorillonite‐catalyzed quinoxaline synthesis is proposed.
ChemInform Abstract: Synthesis of 2H‐1,3‐Benzoxazin‐4(3H)‐one Derivatives Containing Indole Moiety: Their in vitro Evaluation Against PDE4B.
Authors: Rao Raja Mohan , Luther Bethala Jawahar , Rani Chekuri Sharmila , Suresh Namburi , Kapavarapu Ravikumar , Parsa Kishore V. L. , Rao Mandava V. Basaveswara , Pal Manojit
Published: July 2014

10 Title compounds of type (III) are prepared and tested as inhibitors of phosphodiesterase 4 (PDE4).
ChemInform Abstract: Catalyst‐Free Chemo‐/Regio‐/Stereoselective Amination of Alk‐3‐ynones. Synthesis of 1,5‐Benzodiazepines and 3‐Amino‐2‐alkenones.
Authors: Solan Agnes , Nisanci Bilal , Belcher Miranda , Young Jonathon , Schaefer Christian , Wheeler Kraig A. , Toeroek Bela , Dembinski Roman
Published: July 2014

The microwave‐assisted cyclocondensation of alkynones (I) with o‐phenylenediamines (II) leads to desired 1,5‐benzodiazepines (III) in good yields.
ChemInform Abstract: Ring‐Closing Metathesis in the Synthesis of Fused Sultones.
Authors: Mondal Shovan , Debnath Sudarshan
Published: July 2014

The precursors are formed from the corresponding phenols by sulfonylation with 2 chloroethylsulfonyl chloride.
ChemInform Abstract: Hydrosilylation of Internal Alkynes Catalyzed by Tris‐Imidazolium Salt‐Stabilized Palladium Nanoparticles.
Authors: Planellas Marc , Guo Wusheng , Alonso Francisco , Yus Miguel , Shafir Alexandr , Pleixats Roser , Parella Teodor
Published: July 2014

Optimized reaction conditions render possible the stereoselective hydrosilylation of internal alkynes to form (E)‐vinylsilanes.
ChemInform Abstract: Sugar‐Derived Cyclic Imines: One‐Pot Synthesis and Direct Functionalization.
Authors: Szczesniak Piotr , Stecko Sebastian , Staszewska‐Krajewska Olga , Furman Bartlomiej
Published: July 2014

Benzyl protected sugar‐derived lactames are easily reduced by Schwartz′s reagent and subsequently converted to C‐glycosides with high α‐diastereoselectivity.
ChemInform Abstract: β‐Selective Mannosylation with a 4,6‐Silylene‐Tethered Thiomannosyl Donor.
Authors: Heuckendorff Mads , Bendix Jesper , Pedersen Christian M. , Bols Mikael
Published: July 2014

New conformationally restricted mannopyranoside donors react with various acceptors with high β‐selectivity under various reaction conditions, among other using simple NIS/TfOH procedure.
ChemInform Abstract: Further Constituents of Galianthe thalictroides (Rubiaceae) and Inhibition of DNA Topoisomerases I and IIα by Its Cytotoxic β‐Carboline Alkaloids
Authors: de Oliveira Figueiredo Patricia , Perdomo Renata Trentin , Garcez Fernanda Rodrigues , de Fatima Cepa Matos Maria , de Carvalho Joao Ernesto , Garcez Walmir Silva
Published: July 2014

isolation of a new cytotoxic alkaloid (I), which exhibits potent antitopoisomerase I and IIα activities
ChemInform Abstract: Benzopyranone, Benzophenone, and Xanthone Derivatives from the Soil Fungus Penicillium citrinum PSU‐RSPG95.
Authors: Trisuwan Kongkiat , Rukachaisirikul Vatcharin , Borwornwiriyapan Kawitsara , Phongpaichit Souwalak , Sakayaroj Jariya
Published: July 2014

The two new benzopyranones [coniochaetone E (Ia) and coniochaetone F (Ib)], xanthone [penicillone C (II)], and the new benzophenone [penicillanone (III)] are isolated from the title fungus along with ten known compounds.
ChemInform Abstract: Synthesis and Antifungal Activity of ASP9726, a Novel Echinocandin with Potent Aspergillus hyphal Growth Inhibition.
Authors: Morikawa Hiroshi , et al. et al.
Published: July 2014

The synthesis and antifungal activity of ASP9726 (I) is outlined.
ChemInform Abstract: The Effect of Doping V2O5 on Crystallization and Physical Properties of ZnO Nanoparticles.
Authors: Gharibe Soodabe , Vafayi Leila , Afshar Shahrara
Published: July 2014

V2O5‐doped ZnO nanoparticles are synthesized by the wet incipient method from an aqueous suspension of ZnO nanoparticles (obtained from a solution of Zn(OAc)2, cetyltrimethylammonium bromide, and NaOH in EtOH at 70 °C for 2 h) and NH4VO3 at 70 °C, followed by calcination at 400 °C for 2 h.
ChemInform Abstract: Ni‐Cu‐Zn Ferrite Research: A Brief Review
Authors: Huq M. F. , Saha D. K. , Ahmed R. , Mahmood Z. H.
Published: July 2014

Review: 120 refs.
ChemInform Abstract: Review on Palladium‐Containing Perovskites: Synthesis, Physico‐Chemical Properties and Applications in Catalysis
Authors: Essoumhi Abdellatif , El Kazzouli Said , Bousmina Mosto
Published: July 2014

Review: 143 refs.
ChemInform Abstract: Controlled Synthesis of Porous Platinum Nanostructures for Catalytic Applications
Authors: Cao Yanqin , Zhang Junwei , Yang Yong , Huang Zhengren , Nguyen Viet Long , Nogami Masayuki
Published: July 2014

Review: 107 refs.
ChemInform Abstract: The Phomactin Natural Products from Isolation to Total Synthesis: A Review
Authors: Ciesielski Jennifer , Frontier Alison
Published: July 2014

Review: 75 refs.
ChemInform Abstract: Photoactive Assemblies of Organic Compounds and Biomolecules: Drug—Protein Supramolecular Systems
Authors: Vaya Ignacio , Lhiaubet‐Vallet Virginie , Jimenez M. Consuelo , Miranda Miguel A.
Published: July 2014

Review: 163 refs.
ChemInform Abstract: Chemical Designs of Functional Photoactive Molecular Assemblies
Authors: Yan Qifan , Luo Zhouyang , Cai Kang , Ma Yuguo , Zhao Dahui
Published: July 2014

Review: 121 refs.
ChemInform Abstract: Radiochemical Synthesis of 2′‐[18F]‐Labeled and 3′‐[18F]‐Labeled Nucleosides for Positron Emission Tomography Imaging
Authors: Meyer Jan‐Philip , Probst Katrin C. , Westwell Andrew D.
Published: July 2014

Review: 36 refs.
ChemInform Abstract: Chemistry of Iron N‐Heterocyclic Carbene Complexes: Syntheses, Structures, Reactivities, and Catalytic Applications
Authors: Riener Korbinian , Haslinger Stefan , Raba Andreas , Hoegerl Manuel P. , Cokoja Mirza , Herrmann Wolfgang A. , Kuehn Fritz E.
Published: July 2014

Review: 303 refs.
ChemInform Abstract: Five‐Membered Ring Systems: Furans and Benzofurans
Authors: Yeung Kap‐Sun , Peng Xiao‐Shui , Wu Jie , Fan Renhua , Hou Xue‐Long
Published: July 2014

Review: [synthesis and reactions of furans, tetrahydrofurans, benzofurans and their dervatives; 292 refs.
ChemInform Abstract: Garner′s Aldehyde as a Versatile Intermediate in the Synthesis of Enantiopure Natural Products
Authors: Passiniemi Mikko , Koskinen Ari M. P.
Published: July 2014

Review: 115 refs.
ChemInform Abstract: Review of Methods for the Catalytic Hydrogenation of Carboxamides
Authors: Smith Andrew M. , Whyman Robin
Published: July 2014

Review: 204 refs.
ChemInform Abstract: Synthesis and Properties of [60] Fullerene Derivatives Functionalized Through Copper Catalyzed Huisgen Cycloaddition Reactions
Authors: Segura Jose L. , Castelain Marta , Salavagione Horacio
Published: July 2014

Review: 54 refs.
ChemInform Abstract: Insights on the Design and Electron‐Acceptor Properties of Conjugated Organophosphorus Materials
Authors: Baumgartner Thomas
Published: July 2014

Review: 42 refs.
ChemInform Abstract: Iranian Chemist′s Efforts to Provide Various Effective Methods for the Synthesis of Xanthenes
Authors: Shirini Farhad , Abedini Masoumeh , Akbari‐Dadamahaleh Somayeh , Rahmaninia Arman
Published: July 2014

Review: 151 refs.
ChemInform Abstract: Natural Products Chemistry and Environmental Chemistry
Authors: Fabiano‐Tixier Anne‐Sylvie , Culioli Gerald
Published: July 2014

Review: 1 refs.
ChemInform Abstract: Bridging the Chemical and Biological Catalysis Gap: Challenges and Outlooks for Producing Sustainable Chemicals
Authors: Schwartz Thomas J. , O'Neill Brandon J. , Shanks Brent H. , Dumesic James A.
Published: July 2014

Review: 122 refs.
ChemInform Abstract: UV‐Light‐Induced Water Condensation in Air and the Role of Hydrogen Peroxide
Authors: Yoshihara Keitaro , Sakamoto Yosuke , Kawasaki Masahiro , Takatori Yoshiki , Kato Shungo , Kajii Yoshizumi
Published: July 2014

Review: 28 refs.
ChemInform Abstract: Template Effects and Supramolecular Control of Photoreactions in Solution
Authors: Bibal Brigitte , Mongin Cedric , Bassani Dario M.
Published: July 2014

Review: 276 refs.
Critical review of mutual diffusion coefficient measurements for liquid solvent + bitumen/heavy oil mixtures
Authors: Ghanavati Mohsen , Hassanzadeh Hassan , Abedi Jalal
Published: July 2014

Information about diffusion in solvent + bitumen/heavy oil mixtures is useful for the design of solvent‐assisted recovery processes as a key parameter in reservoir simulation models. Reliable mutual diffusion coefficient measurements for these systems present significant challenges. In this article, experimental techniques for the study of diffusion in liquid solvent + bitumen/heavy oil systems are critically reviewed, and the strengths and weaknesses of each method are highlighted. Despite considerable progress in this area with the application of state‐of‐the‐art techniques, such as X‐ray computer‐assisted tomography measurements, additional work is needed to measure the composition profiles in these opaque systems more precisely and to analyse the measured concentration profiles more conveniently.
N‐Acyl Derivatives of 4‐Phenoxyaniline as Neuroprotective Agents
Authors: Barho Marlene T. , Oppermann Sina , Schrader Florian C. , Degenhardt Inga , Elsässer Katharina , Wegscheid‐Gerlach Christof , Culmsee Carsten , Schlitzer Martin
Published: July 2014

Neuronal cell death is the main cause behind the progressive loss of brain function in age‐related neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases. Despite the differing etiologies of these neurological diseases, the underlying neuronal damage is triggered by common mechanisms such as oxidative stress, impaired calcium homeostasis, and disrupted mitochondrial integrity and function. In particular, mitochondrial fragmentation, mitochondrial membrane permeability, and the release of death‐promoting factors into the cytosol have been revealed as the “point of no return” in programmed cell death in neurons. Recent studies revealed a pivotal role for the pro‐apoptotic Bcl‐2‐family protein Bid in models of neuronal cell death, which confirmed Bid as a potential drug target. Herein, we present N‐acyl‐substituted derivatives of 4‐phenoxyaniline that were screened for their potential to attenuate Bid‐mediated neurotoxicity. These compounds provided significant protection against glutamate‐ and Bid‐induced toxicity in cultured neurons. Substitution of the amino group in the 4‐phenoxyaniline scaffold with 4‐piperidine carboxylic acid and N‐hydroxyethyl‐4‐piperidine carboxylic acid yielded compounds that displayed significant neuroprotective activity at concentrations as low as 1 μM. Furthermore, findings of a tBid‐overexpression assay and real‐time measurements of cell impedance support the hypothesis that these compounds indeed address the Bid protein.
Indolicidin Targets Duplex DNA: Structural and Mechanistic Insight through a Combination of Spectroscopy and Microscopy
Authors: Ghosh Anirban , Kar Rajiv Kumar , Jana Jagannath , Saha Abhijit , Jana Batakrishna , Krishnamoorthy Janarthanan , Kumar Dinesh , Ghosh Surajit , Chatterjee Subhrangsu , Bhunia Anirban
Published: July 2014

Indolicidin (IR13), a 13‐residue antimicrobial peptide from the cathelicidin family, is known to exhibit a broad spectrum of antimicrobial activity against various microorganisms. This peptide inhibits bacterial DNA synthesis resulting in cell filamentation. However, the precise mechanism remains unclear and requires further investigation. The central PWWP motif of IR13 provides a unique structural element that can wrap around, and thus stabilize, duplex B‐type DNA structures. Replacements of the central Trp‐Trp pair with Ala‐Ala, His‐His, or Phe‐Phe residues in the PxxP motif significantly affects the ability of the peptide to stabilize duplex DNA. Results of microscopy studies in conjunction with spectroscopic data confirm that the DNA duplex is stabilized by IR13, thereby inhibiting DNA replication and transcription. In this study we provide high‐resolution structural information on the interaction between indolicidin and DNA, which will be beneficial for the design of novel therapeutic antibiotics based on peptide scaffolds.
Defective α‐Fe2O3(0001): An ab Initio Study
Authors: Nguyen Manh‐Thuong , Seriani Nicola , Gebauer Ralph
Published: July 2014

By using density functional theory calculations at the PBE+U level, we investigated the properties of hematite (0001) surfaces decorated with adatoms/vacancies/substituents. For the most stable surface termination over a large range of oxygen chemical potentials (${\mu _{\rm{O}} }$), the vacancy formation and adsorption energies were determined as a function of ${\mu _{\rm{O}} }$. Under oxygen‐rich conditions, all defects are metastable with respect to the ideal surface. Under oxygen‐poor conditions, O vacancies and Fe adatoms become stable. Under ambient conditions, all defects are metastable; in the bulk, O vacancies form more easily than Fe vacancies, whereas at the surface the opposite is true. All defects, that is, O and Fe vacancies, Fe and Al adatoms, and Al substituents, induce important modifications to the geometry of the surface in their vicinity. Dissociative adsorption of molecular oxygen is likely to be exothermic on surfaces with Fe/Al adatoms or O vacancies.