bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Table S2 from Circulating Sex Hormone Levels and Risk of Gastrointestinal Cancer: Systematic Review and Meta-Analysis of Prospective Studies
Authors: Liu Zhiqiang , Zhang Yingfan , Lagergren Jesper , Li Shanshan , Li Jingru , Zhou Zhixian , Hu Zhijian , Xie Shao-Hua
Published: May 2023

Supplementary Table S2 shows adjusted or matched covariates and sex hormone measurement methods of studies included in the meta-analysis.
Supplementary Table 3 from Hepatocellular Carcinoma Surveillance among Individuals with Cirrhosis: Trends by Payer, Etiology, and Calendar Year, from a Statewide, Multi-Payer Dataset, 2010–2018
Authors: Hsu Christine D. , Henderson Louise M. , Jackson Bradford E. , Baggett Christopher D. , Funk Michele Jonsson , Olshan Andrew F. , Gupta Parul , Barritt A. Sidney , Sanoff Hanna K. , Wheeler Stephanie B. , Moon Andrew M. , Lund Jennifer L.
Published: May 2023

Supplementary Table 3 includes hypothetical examples for calculating the Proportion of Time Covered measures.
Supplementary Figure S6 from Circulating Sex Hormone Levels and Risk of Gastrointestinal Cancer: Systematic Review and Meta-Analysis of Prospective Studies
Authors: Liu Zhiqiang , Zhang Yingfan , Lagergren Jesper , Li Shanshan , Li Jingru , Zhou Zhixian , Hu Zhijian , Xie Shao-Hua
Published: May 2023

Supplementary Figure S6 shows forest plots (1), sensitivity analysis (2) and funnel plots (3) of the associations between prediagnostic circulating sex hormone levels and colon cancer risk.
Supplementary Table 15 from Hepatocellular Carcinoma Surveillance among Individuals with Cirrhosis: Trends by Payer, Etiology, and Calendar Year, from a Statewide, Multi-Payer Dataset, 2010–2018
Authors: Hsu Christine D. , Henderson Louise M. , Jackson Bradford E. , Baggett Christopher D. , Funk Michele Jonsson , Olshan Andrew F. , Gupta Parul , Barritt A. Sidney , Sanoff Hanna K. , Wheeler Stephanie B. , Moon Andrew M. , Lund Jennifer L.
Published: May 2023

Supplementary Table 15 includes one-year cumulative incidences for HCC surveillance overall and by insurance type, by calendar year of cirrhosis diagnosis, without imputing deaths for individuals insured through private insurance (% and 95% confidence intervals).
Antitumor Efficacy of the Novel KIT Inhibitor IDRX-42 (Formerly M4205) in Patient- and Cell Line–Derived Xenograft Models of Gastrointestinal Stromal Tumor (GIST)
Authors: De Sutter Luna , Wozniak Agnieszka , Verreet Jasper , Vanleeuw Ulla , De Cock Lore , Linde Nina , Drechsler Christine , Esdar Christina , Sciot Raf , Schöffski Patrick
Published: May 2023

Purpose:

The majority of gastrointestinal stromal tumors (GIST) are driven by constitutively activated KIT/PDGFRA kinases and are susceptible to treatment with tyrosine kinase inhibitors. During treatment, most of these tumors will develop secondary mutations in KIT or PDGFRA inducing drug resistance, so there is an unmet need for novel therapies. We tested the efficacy of IDRX-42, a novel selective KIT inhibitor with high activity toward the most relevant KIT mutations, in 4 GIST xenograft models.

Experimental Design:

NMRI nu/nu mice were transplanted with patient-derived GIST xenograft models UZLX-GIST9 (KIT:p.P577del;W557LfsX5;D820G), UZLX-GIST2B (KIT:p.A502_Y503dup), UZLX-GIST25 (KIT:p.K642E), and the cell line–derived model GIST882 (KIT:p.K642E). Mice were treated daily with vehicle (control), imatinib (100 mg/kg), sunitinib (20 mg/kg), avapritinib (5 mg/kg), or IDRX-42 (10 mg/kg, 25 mg/kg). Efficacy was assessed by tumor volume evolution, histopathology, grading of histologic response, and IHC. The Kruskal–Wallis and Wilcoxon matched-pairs tests were used for statistical analysis, with P < 0.05 considered as significant.

Results:

IDRX-42 (25 mg/kg) caused tumor volume shrinkage in UZLX-GIST25, GIST882, and UZLX-GIST2B, with a relative decrease to 45.6%, 57.3%, and 35.1% on the last day as compared with baseline, and tumor growth delay (160.9%) compared with control in UZLX-GIST9. Compared with controls, IDRX-42 (25 mg/kg) induced a significant decrease in mitosis. In UZLX-GIST25 and GIST882 grade 2–4 histologic response with myxoid degeneration was observed in all IDRX-42 (25 mg/kg)-treated tumors.

Conclusions:

IDRX-42 showed significant antitumor activity in patient- and cell line–derived GIST xenograft models. The novel kinase inhibitor induced volumetric responses, decreased mitotic activity, and had antiproliferative effects. In models with KIT exon 13 mutation IDRX-42 induced characteristic myxoid degeneration.
Targeting BET Proteins Downregulates miR-33a To Promote Synergy with PIM Inhibitors in CMML
Authors: Letson Christopher T. , Balasis Maria E. , Newman Hannah , Binder Moritz , Vedder Alexis , Kinose Fumi , Ball Markus , Kruer Traci , Quintana Ariel , Lasho Terra L. , Finke Christy M. , Almada Luciana L. , Grants Jennifer M. , Zhang Guolin , Fernandez-Zapico Martin E. , Gaspar-Maia Alexandre , Lancet Jeffrey , Komrokji Rami , Haura Eric , Sallman David A. , Reuther Gary W. , Karsan Aly , Rix Uwe , Patnaik Mrinal M. , Padron Eric
Published: May 2023

Purpose:

Preclinical studies in myeloid neoplasms have demonstrated efficacy of bromodomain and extra-terminal protein inhibitors (BETi). However, BETi demonstrates poor single-agent activity in clinical trials. Several studies suggest that combination with other anticancer inhibitors may enhance the efficacy of BETi.

Experimental Design:

To nominate BETi combination therapies for myeloid neoplasms, we used a chemical screen with therapies currently in clinical cancer development and validated this screen using a panel of myeloid cell line, heterotopic cell line models, and patient-derived xenograft models of disease. We used standard protein and RNA assays to determine the mechanism responsible for synergy in our disease models.

Results:

We identified PIM inhibitors (PIMi) as therapeutically synergistic with BETi in myeloid leukemia models. Mechanistically, we show that PIM kinase is increased after BETi treatment, and that PIM kinase upregulation is sufficient to induce persistence to BETi and sensitize cells to PIMi. Furthermore, we demonstrate that miR-33a downregulation is the underlying mechanism driving PIM1 upregulation. We also show that GM-CSF hypersensitivity, a hallmark of chronic myelomonocytic leukemia (CMML), represents a molecular signature for sensitivity to combination therapy.

Conclusions:

Inhibition of PIM kinases is a potential novel strategy for overcoming BETi persistence in myeloid neoplasms. Our data support further clinical investigation of this combination.
Trimodality Therapy Improves Disease Control in Radiation-Associated Angiosarcoma of the Breast
Authors: Degnim Amy C. , Siontis Brittany L. , Ahmed Safia K. , Hoskin Tanya L. , Hieken Tina J. , Jakub James W. , Baum Christian L. , Day Courtney , Schrup Sarah E. , Smith Lauren , Carter Jodi M. , Sae Kho Tiffany M. , Glazebrook Katrina N. , Vijayasekaran Aparna , Okuno Scott H. , Petersen Ivy A.
Published: May 2023

Purpose:

To evaluate the impact of trimodality treatment versus monotherapy or dual therapy for radiation-associated angiosarcoma of the breast (RAASB) after prior breast cancer treatment.

Experimental Design:

With Institutional Review Board approval, we identified patients diagnosed with RAASB and abstracted data on disease presentation, treatment, and oncologic outcomes. Trimodality therapy included (i) taxane induction, (ii) concurrent taxane/radiation, and then (iii) surgical resection with wide margins.

Results:

A total of 38 patients (median age 69 years) met inclusion criteria. Sixteen received trimodality therapy and 22 monotherapy/dual therapy. Skin involvement and disease extent were similar in both groups. All trimodality patients required reconstructive procedures for wound closure/coverage, compared with 48% of monotherapy/dual therapy patients (P < 0.001). Twelve of 16 (75%) patients receiving trimodality therapy had a pathologic complete response (pCR). With median follow-up of 5.6 years, none had local recurrence, 1 patient (6%) had distant recurrence, and no patients died. Among 22 patients in the monotherapy/dual therapy group, 10 (45%) had local recurrence, 8 (36%) had distant recurrence, and 7 (32%) died of disease. Trimodality therapy demonstrated significantly better 5-year recurrence-free survival [RFS; 93.8% vs. 42.9%; P = 0.004; HR, 7.6 (95% confidence interval, CI: 1.3–44.2)]. Combining all patients with RAASB regardless of treatment, local recurrence was associated with subsequent distant recurrence (HR, 9.0; P = 0.002); distant recurrence developed in 3 of 28 (11%) patients without local recurrence compared with 6 of 10 (60%) with local recurrence. The trimodality group had more surgical complications that required reoperation or prolonged healing.

Conclusions:

Trimodality therapy for RAASB was more toxic but is promising, with a high rate of pCR, durable local control, and improved RFS.
A charge na construção dos discursos sobre os gamers
Authors: Caniello Angelica , Souza Luciana Coutinho Pagliarini de
Published: May 2023

Este artigo tem como propósito averiguar possíveis efeitos de sentido atrelados aos gamers, a partir dos discursos propagados pelas charges. Para tanto, valeu-se da Análise de Discurso da linha francesa, de Michel Pêcheux, amparadas em escritos de Eni Orlandi, a fim de vislumbrar os processos da linguagem no contexto sociocultural e histórico em que eles se situam. O tipo de abordagem que as charges oferecem à identidade do gamer concorrem para polemizar o estigma de sujeito com desequilíbrio socioemocional, estereótipo cristalizado na sociedade, que determina o próprio processo de autoimagem do jogador de videogame. Por meio deste artigo, buscamos contribuir com estudos que tenham foco nos discursos sobre gamers, bem como com pesquisas sobre a análise das charges.
Comentários sobre o texto “Som de Rádio”, de Tim Wall
Authors: Gambaro Daniel
Published: May 2023

Comentários sobre o texto “Som de Rádio”, de Tim Wall
Increasing Equity of Physical Activity Promotion for Optimal Cardiovascular Health in Adults: A Scientific Statement From the American Heart Association
Authors: Jerome Gerald J. , Boyer William R. , Bustamante Eduardo E. , Kariuki Jacob , Lopez-Jimenez Francisco , Paluch Amanda E. , Swift Damon L. , Webber-Ritchey Kashica J. , Barone Gibbs Bethany ,   on behalf of the American Heart Association Physical Activity Committee of the Council on Lifestyle and Cardiometabolic Health; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; and Council on Peripheral Vascular Disease
Published: May 2023

Fewer than 1 in 4 adults achieves the recommended amount of physical activity, with lower activity levels reported among some groups. Addressing low levels of physical activity among underresourced groups provides a modifiable target with the potential to improve equity in cardiovascular health. This article (1) examines physical activity levels across strata of cardiovascular disease risk factors, individual level characteristics, and environmental factors; (2) reviews strategies for increasing physical activity in groups who are underresourced or at risk for poor cardiovascular health; and (3) provides practical suggestions for physical activity promotion to increase equity of risk reduction and to improve cardiovascular health. Physical activity levels are lower among those with elevated cardiovascular disease risk factors, among certain groups (eg, older age, female, Black race, lower socioeconomic status), and in some environments (eg, rural). There are strategies for physical activity promotion that can specifically support underresourced groups such as engaging the target community in designing and implementing interventions, developing culturally appropriate study materials, identifying culturally tailored physical activity options and leaders, building social support, and developing materials for those with low literacy. Although addressing low physical activity levels will not address the underlying structural inequities that deserve attention, promoting physical activity among adults, especially those with both low physical activity levels and poor cardiovascular health, is a promising and underused strategy to reduce cardiovascular health inequalities.
Manual and Oscillometric Blood Pressure in tPA‐Treated Acute Ischemic Stroke: What Constitutes Agreement?
Authors: Grove Mary A. , Paliwal Mani , Shearin Anne , Kaiser Jane , Koo Eun Sun , Howey Danielle , Galati Michele , Czekalski Bozena , Dumawal Jennifer , DeCarvalho Briana , Dwyer Jackie , Tsivgoulis Georgios , Alexandrov Andrei V. , Alexandrov Anne W.
Published: May 2023

Background

Automatic noninvasive oscillometric blood pressure (NIBP) devices measure mean arterial pressure (MAP); systolic and diastolic blood pressure (SBP, DBP) are algorithmically derived from MAP. The most invalid NIBP measure is SBP, yet stroke practitioners use it to manage blood pressure (BP) in accordance with thrombolysis guidelines. We determined agreement between SBP, DBP, and MAP measured manually and by NIBP in patients treated with alteplase.

Methods

A multisite prospective observational study of NIBP and manual BP agreement was conducted in patients treated with alteplase immediately after bolus and infusion initiation using methods established in guidelines for the assessment of device agreement. Dual auscultatory stethoscopes were used by 2 investigators to ensure agreement with each manual BP variable and MAP was calculated using the standard formula for manual BP measures. Data were analyzed using Bland–Altman analyses and Lin concordance correlation coefficient.

Results

A total of 7 hospitals participated, collecting 5 sets of manual/NIBP BPs in 95 patients treated with alteplase (475 paired measures). Range in limits of agreement were SBP: −28.91 to 21.41 mmHg with Lin's concordance correlation coefficient 0.8; DBP: −21.0 to 19.0 mmHg with Lin's concordance correlation coefficient 0.69; and MAP: −27.5 to 16.5 mmHg with Lin's concordance correlation coefficient 0.7. There was no difference in device agreement by BP device manufacturer brand. Differences in SBP, DBP, and MAP between NIBP and manual sphygmomanometry failed to reach guideline recommendations requiring 80% of measures to fall within a 5 mmHg difference and 95% of measures to fall within a 10 mmHg difference.

Conclusion

NIBP devices produce significantly different BP measures then manual sphygmomanometry auscultated BP. Because NIBP devices rely on the MAP and do not directly measure SBP and DBP, definition of what constitutes safe MAP boundaries in patients treated with alteplase should be determined when automatic BP measurement is used in clinical practice.
Flow Diversion for Intracranial Aneurysms in Large‐Diameter Vessels: A Subanalysis From the SESSIA Study
Authors: Vivanco‐Suarez Juan , Rodriguez‐Calienes Aaron , Farooqui Mudassir , Rabinovich Margarita , Abouelleil Mohamed , Altschul David J. , Feigen Chaim , Fifi Johanna T. , Matsoukas Stavros , Al‐Mufti Fawaz , Malaga Marco , Galecio‐Castillo Milagros , Wakhloo Ajay K. , Singer Justin A. , Ortega‐Gutierrez Santiago
Published: May 2023

Background

Flow diverters are now considered first‐line tools for treating intracranial aneurysms. However, few devices are available for patients with large‐diameter vessels (LDVs). Hence, we evaluated the performance of the largest diameter Surpass Streamline for aneurysms in LDVs.

Methods

We performed a subanalysis of the SESSIA (Safety and Efficacy of the Surpass Streamline for Intracranial Aneurysms) multicenter cohort study of patients treated with Surpass Streamline between 2018 and 2021. Patients in whom a 5‐mm diameter Surpass Streamline was implanted were divided into 2 groups according to vessel diameter at the landing zones (LDV, ≥5.3 mm versus non‐LDV [N‐LDV], <5.3 mm). Efficacy was complete occlusion at final follow‐up. Safety was ischemic/hemorrhagic events and mortality up to 30 days.

Results

Thirty patients harboring 30 aneurysms were included. Fifteen cases were included per group (LDV versus N‐LDV). Baseline demographics, clinical characteristics, median aneurysm size (LDV, 11 mm versus N‐LDV, 10 mm), and location were similar. Vessel diameters at the proximal (LDV, 5.3 mm versus N‐LDV, 4.2 mm;
P
<0.001) and distal (5.6 versus 4.0 mm;
P
<0.001) flow diverter landing zones were different. Procedural characteristics (including balloon‐assisted angioplasty and stenting) were similar. At the final follow‐up (12±6 months), complete occlusion (LDV, 75% versus N‐LDV, 84%;
P
=0.548), and ischemic/hemorrhagic events (1 per group;
P
=1.00) were not different.

Conclusions

The use of large‐diameter flow diverters for treating complex intracranial aneurysms arising in LDVs is technically feasible and safe. Comparative studies evaluating devices suitable for this patient population will provide valuable insights for the best device selection.
Notes on Leuctra signifera Kempny, 1899 and Leuctra austriaca Aubert, 1954 (Plecoptera: Leuctridae), with the description of a new species
Authors: REDING JEAN-PAUL G. , VINÇON GILLES , GRAF WOLFRAM
Published: May 2023

Leuctra signifera Kempny, 1899 and Leuctra austriaca Aubert, 1954 are re-described and their taxonomical status is discussed. New country records are reported for L. austriaca from Hungary and L. signifera from Italy, Slovenia, and Hungary. A new species, Leuctra papukensis sp. n., from Croatia, is described and illustrated. The subspecies Leuctra signifera jahorinensis Kaćanski, 1972 is raised to species level.
Evaluation of the Relationship Between Radial Artery Intima Media Thickness and Complications at the Intervention Site After Radial Angiography
Authors: Naldemir Ibrahim Feyyaz , Karaman Ahmet Kursat , Güçlü Derya , Koç Ay Esra , Kayapınar Osman , Kaya Adnan , Sarıgedik Enes , Altınsoy Hasan Baki
Published: May 2023

The present study investigated the relationship between pre-procedural radial intima-media thickness (rIMT) and radial artery thrombosis (RAO) in patients undergoing angiography using a transradial approach (TRA). Patients (n = 90) who underwent cerebral or peripheral arterial angiography using TRA were included in the study. Ultrasonographic evaluation was performed before and 12 h after the procedure. Preoperative rIMT measurement was performed at the distal radial artery. Presence of radial artery occlusion was evaluated by ultrasonography after radial catheterization and revealed occlusive thrombus in the radial artery in 13 patients. rIMT was found to be statistically significantly higher in patients with thrombus ( P < .05). When it was evaluated whether there was a correlation between age and rIMT, a positive significant correlation was found ( P < .01). Our study suggests that increase of rIMT may be a risk factor for RAO in the intervention area. Before the procedure, ultrasound (US) assessment of the radial artery may be useful in determining the risk of occlusion. Thus, RAO-related technical risk factors (procedure time, number of punctures, sheath thickness, etc.) can be managed more carefully in patients having radial angiography.
Nanoclay role in improving compression after impact strength of the carbon/epoxy composites
Authors: Fakhreddini-Najafabadi Sajjad , Torabi Mahdi , Taheri-Behrooz Fathollah
Published: May 2023

Polymer matrix composites are vulnerable to low-velocity impact, although they have found many applications in high-tech industries. The main objective of this study is to improve compression after impact strength of the carbon/epoxy composites using nanoclay particles. All test samples were fabricated using a vacuum infusion process. The solution blending methodology was applied for better dispersion of the nanoparticles in the resin. The low-velocity impact response of the composite and nanocomposite laminates was investigated at various energy levels of 10, 15, and 20 J. To quantify the impact effect, the residual strength of the impacted specimens was experimentally measured under the compression test. In addition, the effect of nanoclay incorporation through the solution blending methodology on damage mechanisms was determined by the radiographic analyses and optical microscope method. The findings of this research showed a rise, up to 25.15% in the residual compressive strength, and a 7-fold increase in local buckling threshold stress of the carbon/epoxy/nanoclay specimens.
Drilling of banana stem fibers and polyurethane derived from castor oil composite
Authors: Ellenberger Alessandro , Polli Milton Luiz , Cristina de Azevedo Elaine , Pereira de Paula Caroline Rodrigues
Published: May 2023

Natural fibers composites obtained from waste of agricultural processes appear as an alternative to materials from non-renewable sources. Drilling these composites is challenging due to the non-homogeneous structure and behavior of the natural fibers and the polymeric matrix. This work uses different drill types and machining parameters to investigate the drilling process in a composite with banana stem fibers and polyurethane derived from castor oil. Hole damages, thrust force, torque and chip morphology were evaluated. The best results were found using a twist drill at 19 m/min cutting speed and 0.1 mm/rev feed rate. Drill type was the main factor in generating damage in the holes, while torque and thrust force were less influential.
Public Reactions to Secret Negotiations in International Politics
Authors: Myrick Rachel
Published: May 2023

Many international agreements, from routine trade deals to high-stakes nuclear agreements, are negotiated in secret. However, we have a limited understanding of how secrecy in a negotiation shapes attitudes towards the agreement. Public opinion matters because it informs government decisions about when to conceal or reveal information during a negotiation. In a survey experiment of U.S. adults, I first examine overall attitudes towards secrecy in security and economic agreements. I then randomize government justifications for negotiating in secret: improved success, protection of sensitive information, and anticipation of criticism from domestic and international opponents. I find that respondents are generally averse to secrecy in international negotiations, but there are justifications for its use that they perceive as more legitimate. Secrecy is more permissible when negotiations contain sensitive information or when it improves the likelihood that agreements are reached. It is less permissible when governments negotiate in secret to avoid domestic criticism.
Listening to Preferred and Loud Music Enhances Taekwondo Physical Performances in Adolescent Athletes
Authors: Ouergui Ibrahim , Jebabli Eya , Delleli Slaheddine , Messaoudi Hamdi , Bridge Craig Alan , Chtourou Hamdi , Franchini Emerson , Ballmann Christopher Garrett , Ardigò Luca Paolo
Published: May 2023

In this study, we aimed to investigate the effects of warm-up music preference and loudness on physical performance, perceived exertion (RPE), and enjoyment in young taekwondo athletes. In a crossover counterbalanced design, 20 taekwondo athletes (10 male, 10 female) performed a battery of physical tasks specific to taekwondo under the following five conditions: (a) No music (NM), (b) Preferred music-Soft (60 dB; PMS), (c) Preferred music-Loud (80 dB; PML), (d) Non-preferred music-Soft (60 dB; NPMS), and (e) Non-preferred music-Loud (80 dB; NPML). On each lab visit, participants completed a taekwondo-specific agility test (TSAT), a10-second kick test (KSKT-10s) and a multiple frequency speed of kick tests (FSKT) within each music condition. Pre-exercise enjoyment was assessed using the Physical Activity Enjoyment Scale (PACES) after the warm-up, while we obtained RPE scores after each test. The PML condition resulted in significantly better agility test times on the TSAT compared to PMS ( p < .001), and NPML ( p < .001). Furthermore, PML led to a greater number of total kicks during the FSKT-10s test compared to the PMS ( p < .001), and NPML ( p < .001) conditions. The decrement index on the FSKT was lower in PML than in PMS and NPML conditions ( p < .001). For RPE, values were significantly lower with preferred than non-preferred music ( p < .001). These findings lend support to ergogenic benefits of listening to PML prior to taekwondo physical tasks, with important implications for enhancing taekwondo training and performance.
The association between psychological resilience and hair cortisol concentration in adults: A systematic review and meta-analysis
Authors: Xiang LiWen , Zeng Xia , Luo YinXia , Tan SuFang , Wang Fang , Mao XiaoRong
Published: May 2023

Background

Resilience measures are typically based on subjective self-assessment, which is prone to bias. Objective biological/physiological measures of resilience are therefore needed. Hair cortisol concentration is a particularly promising candidate as a biomarker for resilience.

Methods

We conducted a meta-analytic review from inception to April 2023 in PubMed, EMBASE, Cochrane Library, and Psych Info databases. All data were analyzed using a random-effects model.

Results

Eight studies were identified that included a total of 1,064 adults. The random effects model demonstrated that resilience and hair cortisol concentration were inversely correlated (r = −0.18, 95% confidence interval [CI] = −0.27 to −0.09) with substantial heterogeneity ( I2 = 54.2%, p = 0.03). The inverse association was stronger in those who were age 40 years or younger compared to those who were over 40 years. The correlation coefficients between psychological resilience and hair cortisol concentration among adults assessed by different resilience measures were r = −0.29 (95% CI = −0.49 to −0.08) for the CD-RISC-10; r = −0.21 (95% CI = −0.31 to −0.11) for the CDRISC- 25, and r = −0.08 (95% CI = −0.22 to 0.06) for the BRS. Six of eight studies examined the connection between resilience and perceived stress, where the weighted mean correlation coefficient was r = −0.45 (95% CI = −0.56 to −0.33), with considerable heterogeneity ( I2 = 76.2%, p = 0.001).

Conclusions

There is a negative association between psychological resilience and hair cortisol concentration based on these eight studies. Additional research, particularly prospective studies, is needed to determine whether hair cortisol concentration can be used as a biomarker for psychological resilience.
What we mean by public missiology
Authors: Leffel Gregory P. , Fensham Charles J. , Hunsberger George R. , Hunt Robert A. , Kenney William N. , Okesson Gregg A. , Pieterse Hendrik R.
Published: May 2023

In 2014 and 2015 a panel of missiologists assembled at the American Society of Missiology (ASM) to discuss ideas, concepts, and practices in support of the proposed 2016 ASM annual meeting under the heading “Missiology and Public Life: Mission’s Constructive Engagement with Societies, Change and Conflict.” In these panels, subsequent ASM panel discussions (2017–19), and in two issues of the journal Missiology devoted to the topic (April 2016, January 2017), the concept of public missiology emerged, and from this grew an informal seven-member study group of colleagues to clarify what might be meant by “public missiology” and define its scope. The following summarizes our study group’s conceptualization of public missiology and reflects our thinking to date. We suggest approaching missiological theory and practice from a new direction, one that focuses upon public life and emerging public orders as its object of analysis under the conditions of a rapidly changing world-historical order. This fresh approach to mission studies makes, we believe, an important contribution to ensuring mission’s vitality for the next several decades or for the next half-century.
Disability-Adjusted Life Expectancy and Cognitive Function among Community-Dwelling Adults
Authors: Nam Sanghun , Downer Brian , Cha Suna , Choi Jae-Sung , Yang Seungmin , Hong Ickpyo
Published: May 2023

We aimed to calculate disability-adjusted life expectancy (DALE) for Korean older adults based on their sex, educational attainment, and residential region across their cognitive status. We included 3,854 participants (aged 65–91 years) from the Korean Longitudinal Study of Aging’s seventh survey data. The participant’s cognitive function status (normal, moderately impaired, or severely impaired) was determined based on cognitive examination and physical function independence, which was used to calculate their DALE. Females with normal cognition had higher DALE (7.60 years, Standard Deviation (SD) = 3.88) than males (6.76, SD = 3.40); however, both sexes had comparable DALE for cognitive impairment. In contrast, the DALE values increased with higher educational achievements. Regarding residential areas, the DALE value for participants with normal cognition and moderate impairment was the highest among urban dwellers, while DALE for participants with severely impaired cognitive function was highest among rural dwellers; however, there were no statistically significant differences based on residential conditions. Our findings suggest that demographic characteristics should be considered when developing health policies and treatment strategies to meet the needs of the aging population in Korea.
Discrepancies in parent-adolescent educational and career expectations and overparenting
Authors: Hong Peipei , Cui Ming
Published: May 2023

Informed by the goodness-of-fit model, goal theories, and literature on support gaps, this study examines the associations between congruence/discrepancies in parent-adolescent expectations of the adolescent’s educational and career goals and adolescents’ perceived overparenting. Data were collected through a survey of 122 parent-adolescent dyads from four high schools in the U.S. Results from second-order polynomial regression with response surface analysis indicated that parental high educational or career goal expectation alone was not necessarily related to adolescents’ perception of overparenting. Rather, adolescents’ perception of overparenting depended on the congruence/discrepancies in parents’ and adolescents’ expectations. Compared to parent-adolescent congruence in high or low expectations, either direction of expectation discrepancies—either parents’ expectation exceeds adolescents’ expectation, or adolescents’ expectation exceeds their parents—was more likely to be associated with adolescents’ perception of overparenting. Parenting intervention and educational programs should acknowledge that discrepancies in parents’ and adolescents’ educational and career goals could potentially contribute to parental overparenting. Fostering communication and negotiation of goal expectations between parents and adolescents may help reduce the practice of overparenting.
Mapping entrepreneurship support organisations: An examination of the ‘cluttered landscape’ critique
Authors: Hruskova Michaela , Mason Colin , Herzog Sarah
Published: May 2023

Entrepreneurship support organisations (ESOs) support entrepreneurs with the provision of knowledge, resources, and training. They are a popular economic development tool for promoting entrepreneurial activity. However, the large number of ESOs has led to criticisms of oversaturation. We investigate this claim by analysing the ESOs in the entrepreneurial ecosystem in Glasgow, Scotland. We draw on publicly available documentary data to map the ESOs landscape and adopt the organisational thickness lens to analyse and interpret our findings from a holistic perspective. Although the literature largely presents ESOs as homogenous, we find a large number of heterogeneous ESOs that provide a wide range of support activities which can cater to different needs. However, they do not clearly target a specific segment of entrepreneurs which makes it difficult for the clients to differentiate between them and find the most suitable ESO. This is likely the explanation for the perception of a ‘cluttered landscape’ with too many players. Considering that entrepreneurs draw on different support providers over the course of their entrepreneurial journey, a key implication of our study is that the issue of clutter is likely to improve with greater segmentation rather than reducing the number of ESOs.
Younger, drunk, and fast: Paradoxical rapid reaction time in hazardous drinkers
Authors: Powell Anna , Sumnall Harry , Montgomery Catharine
Published: May 2023

Background:

Research consistently links hazardous alcohol use with reduced cognitive function but is less consistent with regard to processing speed, which underpins many cognitive functions. Using vibrotactile perception to assess cognitive function may have benefits over other sensory stimuli, as this method gives lower variability in reaction time (RT) and shorter latency.

Aims:

This study aimed to assess performance on vibrotactile simple and choice RT tasks between hazardous and non-hazardous drinkers.

Methods:

Participants ( n = 86) completed vibrotactile tasks and alcohol, mood and subjective function (Executive Function Index (EFI)) questionnaires. Multivariate analyses of covariance were performed on average RT scores, and on EFI scores, to investigate function, and a bivariate correlation assessed the relationships between subjective and objective measures.

Results:

Hazardous drinkers exhibited significantly faster choice RT. With regard to subjective executive function, Strategic Planning and Impulse Control were significantly better in non-hazardous drinkers. Finally, Organisation and Impulse Control both significantly positively correlated with choice and simple RT, indicating that as subjective function improved, RT increased (a decline in performance).

Conclusions:

These results are considered in the context of the premature ageing hypothesis, impulsivity and the impact of alcohol use on various neurotransmitter systems. Furthermore, the poorer subjective function in young hazardous drinkers indicates a possible metacognitive deficit, increased effort or issues with vibrotactile perception as a cognitive function assessment in this group.
An ophthalmologist fought against trachoma in Turkey and his books from an archive: Dr Nuri Fehmi Ayberk and The Development of Ophthalmology in Turkey
Authors: Üstün Çağatay , Özçiftçi Seçil
Published: May 2023

Dr Nuri Fehmi Ayberk is an influential figure in the Turkish ophthalmology in training new specialists in the field and contributing to the fight against trachoma. This article includes his short biography, studies, information and cover pictures of some of his works from the original archive of Ege University Faculty of Medicine, Department of History of Medicine and Ethics, Fatma-Ömer Ekimci Library. He took an active role in the establishment of the Turkish Ophthalmological Association in our country (1928) and served as a founding member. Conducting such studies on the biographies and rare books subgroup of the history of medicine is an important contribution to ensure that the biographies of physicians who have left their mark in the past and have achieved success in different specialties are narrated, remembered, and the information and cover pictures of their works in different archives meet with the reader.
Alignment of Goals for Personal Interpretation Among Staff Groups in a Park Agency
Authors: Hvenegaard Glen T. , Halpenny Elizabeth A. , Blye Clara-Jane
Published: May 2023

Goal alignment among staff members helps an agency perform well. This study examines goal alignment for park staff regarding their priorities for interpretation and perceptions of what helps and hinders achievement of those goals. We surveyed 86 staff from Alberta Parks, who rated potential goals for personal interpretation and expressed views on the catalysts and constraints that affected the achievement of those goals. There was alignment in interpretation goals among staff groups (i.e., planners/managers, interpretive supervisors, and frontline interpreters). Staff thought that all goals were important, but ranked the goals of positive memories, enjoyment, and connections to place higher than the goals of behavior change, positive attitudes, and learning. Factors supporting success were supportive supervisors, hiring and retaining excellent staff, and training, whereas factors hindering success were resource deficits, bureaucracy, and lack of common goals. To promote goal alignment, agencies can improve communication, planning, staff engagement, training, and research.
Lambl’s Excrescence as an Etiology of Thromboembolism: Case Report and Literature Review
Authors: Alajjuri Mohammad Ala’ , Alajjuri Omar Ala’ , Alani Firas Raouf
Published: May 2023

Lambl’s excrescence (LE), a rare thin linear fibrous thread of collagen and elastic fibrous tissue originating at closure margins of heart valve leaflets is considered a rare cause of thromboembolism, causing ischemic stroke, transient ischemic attack (TIA), acute coronary syndrome, or peripheral thromboembolism. The gold standard for diagnosing LE is transesophageal echocardiography (TEE). Due to the rarity of the disease and lack of significant research, no guidelines exist about the management of LE. Twenty-two papers about LE were reviewed, focusing on the management aspect aiming to assist in guideline publication. Articles were retrieved using PubMed database using “Lambl’s excrescences” as a keyword. All free full text papers up to 2023 were retrieved. In this report, we present the first publication of a case of a TIA secondary to LE in the United Arab Emirates. A 53-year-old male presented with transient attacks of left monocular blindness with complete recovery 2 days later. Extensive stroke work-up was negative, except for TEE, which showed an echo-dense linear mobile structure attached to the aortic surface of the aortic valve closure margin, suggesting LE. As no guidelines exist on the management of LE, the patient was started on Clopidogrel 75 mg daily and remained asymptomatic for 2 years. After reviewing the literature, we suggest the use of Aspirin for patients with ⩾1 embolic event attributed to LE while not on antiplatelets or anticoagulants, as it is the most used and recommended treatment option and is effective in preventing recurrent thromboembolic events.
The influence of musical production structures in group learning management
Authors: Baño Lucas , Pozo Juan Ignacio
Published: May 2023

Despite research indicating the advantages of collaborative learning, most formal music education continues to be in an individual format. However, collaborative strategies have been observed in other musical cultures. Through this research, we wished to study the differences in the management of group practices between three musical cultures (classical, modern, and flamenco), checking whether they originate in the formal/informal nature of their cultural tools or their mode of musical production. For this purpose, we analyzed three musical groups belonging to these three musical cultures. Each group comprised four musicians. Recordings of the rehearsal sessions and three dimensions of learning (outcomes, processes, and conditions) were categorically analyzed using the system for the analysis of instrumental learning developed by our research group. Chi-square and adjusted standardized residuals analyses demonstrated that the learning outcomes in each culture differed according to the cultural tool used (literacy, orality, or mimetic), but that the processes and social interaction differed according to the mode of musical production. The findings suggested that those who approach music from open production structures, such as modern musicians, are more collaborative than those who approach it from closed structures, such as classical and flamenco musicians. We conclude by reflecting on the origin of these production structures, highlighting the need to work from different modes of musical production in educational spaces.
‘Recreational shaming groups of Facebook: Content, rules and modministrators’ perspectives’
Authors: Murumaa-Mengel Maria , Lott Kaarel
Published: May 2023

As social life and communication move increasingly online, we have experienced the expansion and the normalisation of online shaming – different forms of (semi)public cross-platform condemnation of people and their actions by (mass) online audiences. Online shamings can be analysed as combinations of reintegrative (shame-correct-forgive) and disintegrative (shame-stigmatise-expel) social sanctioning practices, usually focusing the ‘serious’ disciplinary shaming on the behaviour of the offender. We propose that equal attention should be given to what we have termed ‘recreational shaming’ – humour-based playful collective shaming that often occurs via online platforms, seemingly just for the sake of shaming, motivated mainly by social belonging needs and entertainment gratification.

By combining the results of standardised content analysis of Facebook recreational shaming groups ( n = 65) and in-depth qualitative interviews with the ‘modmins’ of the groups ( n = 8) we will give an overview of what is being shamed, how groups and modministrators create and enforce rules and what is the socio-cultural perceived meaning of this practice. We distinguish three spheres of recreational shaming that ‘frame the shame’ and demonstrate how recreational online shaming is often more about the self than the other – me performing the act of shaming for entertainment value, to belong in a group. Additionally, we introduce how shaming is used as a self-reflexive tool for behaviour-correction or base knowledge for dominant tastes.
Effectiveness of speech therapy in treating vocal blocking tics in children with Tourette syndrome: Two case reports
Authors: Peltokorpi Sini , Laiho Auli , Carlson Vappu , Raaska Hanna
Published: May 2023

Tourette syndrome is characterized by at least two motor tics and one vocal tic, which persist for over a year. Infrequently, tics can manifest as blocking tics in speech when they prevent a person from starting to speak or interrupt their speech flow. Vocal blocking tics (VBTs) resemble stuttering, and they can be difficult to differentiate from each other. A previous report described two patients with severe VBTs who did not benefit from stuttering-therapy-based speech therapy and were treated effectively with cannabis-based medicine. Here, we present the cases of two patients, seven- and nine-year-old boys, who benefited from speech therapy in which stuttering therapy techniques were used. Detailed descriptions of the interventions are included. Further research is needed to test the effectiveness of speech therapy in treating VBTs in a larger group of children with Tourette syndrome.
Multidisciplinary coordination of care for children with esophageal atresia and tracheoesophageal fistula
Authors: Platt Jody M , Nettel-Aguirre Alberto , Bjornson Candice L , Mitchell Ian , Davis Kathryn , Bailey JA Michelle
Published: May 2023

Esophageal Atresia/Tracheoesophageal Atresia (EA/TEF) is a multisystem congenital anomaly. Historically, children with EA/TEF lack coordinated care. A multidisciplinary clinic was established in 2005 to provide coordinated care and improve access to outpatient care. This single-center retrospective cohort study was conducted to describe our cohort of patients with EA/TEF born between March 2005 and March 2011, assess coordination of care, and to compare outcomes of children in the multidisciplinary clinic to the previous cohort without a multi-disciplinary clinic. A chart review identified demographics, hospitalizations, emergency visits, clinic visits, and coordination of outpatient care. Twenty-seven patients were included; 75.9% had a C-type EA/TEF. Clinics provided multidisciplinary care and compliance with the visit schedule was high with a median of 100% (IQR 50). Compared to the earlier cohort, the new cohort ( N = 27) had fewer hospital admissions and LOS was reduced significantly in the first 2 years of life. Multidisciplinary care clinics for medically complex children can improve coordination of visits with multiple health care providers and may contribute to reduced use of acute care services.
Expecting the unpredictable: Categorisation of children and youth during driver training
Authors: Willemsen Annerose , Cromdal Jakob , Broth Mathias
Published: May 2023

This paper presents an analysis of how the particular categories of children and youth are used within the instructional work of learning to drive. Using Membership Categorisation Analysis (MCA) and multimodal Conversation Analysis (CA) of a collection of cases drawn from 85 video-recorded driving lessons, we demonstrate how the participants treat children and youth as a category of traffic users whose main category predicate appears to be their expected unpredictability and carelessness, placing particularly high demands on drivers’ awareness and caution. This is evident in in-event and post-event interactions about traffic encounters with children and youth, as well as in traffic contexts where they have not (yet) been spotted but their sudden appearance is anticipated. The results suggest that the institutional constructions of children and youth as a potential source of trouble prepare trainee drivers for unforeseen events and contingencies and shape their social stock of knowledge as future motorists.
The Moby Bookmobile: Providing Health Education Materials in Wyoming Indian Country
Authors: Levin Robin , Brown David , Bramble John
Published: May 2023

The COVID-19 pandemic made it difficult for Native American populations to access health information. Through funding from the Network of The National Library of Medicine Region 4, a community library was able to enhance their native and nonnative health collections for distribution on the Wind River Reservation in Central Wyoming. The book mobile was originally funded by the Wyoming State Library through American Rescue Plan Act of 2021 funding to increase literacy efforts during the pandemic. Materials were distributed at multiple locations throughout the reservation and individuals indicated they appreciated the materials being provided. This program was successful in distributing health information to an underserved priority population within the United States. Hopefully, similar programs would be successful in enhancing health education programs with other priority populations in both the United States and the world.