bluuebunny/crossref_metadata_2025 huggingface dataset:
Biomarker Validation of a New Case Definition of Menstrual Cycle-Associated Syndrome (MCAS) Opinion Paper
Authors: Roomruangwong Chutima , Maes Michael
Published: October 2020

There are different case definitions of premenstrual syndrome, one proposed by the
American College of Obstetricians and Gynecologists (ACOG) and another based on the Daily Record
of Severity of Problems (DRSP) scores. Here we review our recent findings indicating that the
gold-standard methods to assess PMS, including ACOG, provide a high degree of false-negative
findings. We propose a new case definition of the Menstrual Cycle-Associated Syndrome (MCAS),
which is characterized by increased DRSP scores during the menstrual cycle and symptom that increases
the week prior to the menses. The MCAS case definition was externally validated by diverse
biomarkers including plasma levels of progesterone and estradiol, chemokines (e.g. CCL2,
CCL5 and CCL11), epidermal growth factor, hydroperoxides, paraoxonase 1 activity and complement
C4. These biomarkers as well as IgA responses to Gram-negative bacteria are significantly associated
with the DRSP and its subdomains including depression, anxiety, and physiosomatic
symptoms(fatigue, pain). In conclusion, we propose, a) to use the MCAS diagnosis as an indicant
of menstrual cycle-related symptoms; and b) to examine the associations of the time series in the
DRSP and its subdomains and those in biomarkers including distributed lag models. Aberrations in
the uterine-chemokine-brain-axis underpin the pathophysiology of MCAS whereby suboptimal
pre-ovulatory follicular development coupled with a relative corpus luteum insufficiency may
drive increased chemokine production, lowered antioxidant defenses, neuro-oxidative stress pathways,
and increased bacterial translocation. As such, we have delineated new drug targets for the
treatment of MCAS. This opinion paper reviews new possible treatments that should be trialed in
MCAS.
Role of Forkhead Transcription Factors of the O Class (FoxO) in Development and Progression of Alzheimer’s Disease
Authors: Goswami Shikha , Kareem Ozaifa , Goyal Ramesh K. , Mumtaz Sayed M. , Tonk Rajiv K. , Gupta Rahul , Pottoo Faheem H.
Published: October 2020

:

In the central nervous system (CNS), a specific loss of focal neurons leads to mental and
neurological disorders like dementia, Alzheimer’s disease (AD), Huntington’s disease, Parkinson’s
disease, etc. AD is a neurological degenerative disorder, which is progressive and irreversible in nature
and is the widely recognized reason for dementia in the geriatric populace. It affects 10% of
people above the age of 65 and is the fourth driving reason for death in the United States. Numerous
evidence suggests that the neuronal compartment is not the only genesis of AD, but transcription
factors also hold significant importance in the occurrence and advancement of the disease. It is
the need of the time to find the novel molecular targets and new techniques for treating or slowing
down the progression of neurological disorders, especially AD. In this article, we summarised a
conceivable association between transcriptional factors and their defensive measures against neurodegeneration
and AD. The mammalian forkhead transcription factors of the class O (FoxO) illustrate
one of the potential objectives for the development of new methodologies against AD and
other neurocognitive disorders. The presence of FoxO is easily noticeable in the “cognitive centers”
of the brain, specifically in the amygdala, hippocampus, and the nucleus accumbens. FoxO
proteins are the prominent and necessary factors in memory formation and cognitive functions.
FoxO also assumes a pertinent role in the protection of multiple cells in the brain by controlling the
involving mechanism of autophagy and apoptosis and also modulates the process of phosphorylation
of the targeted protein, thus FoxO must be a putative target in the mitigation of AD. This review
features the role of FoxO as an important biomarker and potential new targets for the treatment
of AD.
Differential Metabolites Markers from Trunking and Stressed Non-Trunking Sago Palm (Metroxylon sagu Rottb.)
Authors: Hussain Hasnain , Yan Wei-Jie , Ngaini Zainab , Julaihi Norzainizul , Tommy Rina , Bhawani Showkat Ahmad
Published: October 2020

Background:

Sago palm is an important agricultural starch-producing crop in Malaysia.
The trunk of sago palm is responsible for the the starch to reach maturity for harvesting
after ten years. However, there are sago palms that fail to develop thier trunk after 17
years of being planted. This is known as a stressed “non-trunking” sago palm, which reduces
the economic value of the palms.

Objective:

The study was initiated to compare the differences in metabolite expression between
trunking and non-trunking sago palms and secondly to determine the potential metabolite-
makers that are related to differential phenotypes of sago palms.

Methods:

Metabolites were extracted using various solvents and analysed using NMR spectroscopy
and GC-MS spectrometry. Data obtained were subjected to principal component
analysis.

Results:

The study determined differential metabolites expression in the leaf extracts of
normal trunking sago palm compared to the non-trunking palms. Metabolite groups differently
expressed between trunking and non-trunking sago palm are oils and waxes, haloalkanes,
sulfite esters, phosphonates, phosphoric acid, thiophene ester, terpenes and tocopherols.
GC-MS analysis of Jones & Kinghorn extraction method determined two sets of metabolite
markers, explaining the differences in metabolites expression of trunking and nontrunking
sago palms in ethyl acetate and methanol extract of 89.55% comprising sulfurous
ester compounds and 87.04% comprising sulfurous ester, sulfurous acid and cyclohexylmethyl
hexyl ester, respectively.

Conclusion:

Two sets of metabolite markers were expressed in the trunking and nontrunking
sago palms. These metabolites can potentially be used as markers for identifying
normal and stressed plants.
Nanosizing Nigella: A Cool Alternative to Liberate Biological Activity
Authors: Vaso Mariza , Ali Wesam , Masood Muhammad Irfan , Nasim Muhammad Jawad , Lilischkis Rainer , Schäfer Karl-Herbert , Schneider Marc , Papajani Vilma Toska , Jacob Claus
Published: October 2020

Background:

Seeds of Nigella sativa, commonly referred to as “black cumin”, are rich
in a spectrum of biologically active substances and thus associated with a range of potential health
benefits. Unlocking the activity of these phytochemicals traditionally requires solvent extraction.
Previously, we have explored nanosizing as an alternative to liberate the biological activity of
natural products, such as Solanum incanum, Pterocarpus erinaceus, Loranthus micranthus and
Cynomorium coccineum.

Objectives:

Nanosizing natural products may increase their activity for a number of reasons
ranging from an improved bioavailability to physical nano-toxicity. Because Nigella sativa is
amenable to being “milled down”, this spice has been employed to explore the underlying causes
of increased activity upon mechanical particle size reduction.

Methods:

Nigella sativa seeds were pre-milled employing a household flour mill followed by
extensive grinding exploiting a planetary ball mill. The particles were characterized employing
Laser Diffraction, Photon Correlation Spectroscopy and Scanning Electron Microscopy connected
with Energy Dispersive X-ray Diffraction. Finally, the samples were evaluated for sterility profile,
and nematicidal and antioxidant activities.

Results:

Suspensions containing fairly uniform particles of Nigella sativa showing diameters in the
range of 100-1000 nm have been obtained. These nanosuspensions are characterized by
considerably reduced microbial contamination when compared to the bulk material and reasonable
antioxidant and nematicidal activities when employed at higher concentrations. This activity is
comparable to the one of the ethanolic extract of the seeds and is significantly higher when
compared to the one of aqueous extracts. A combination of “sterilization and extraction by
milling”, improved liberation of soluble substances from small particles, surface activity and
physical nano-activity of the particles itself is likely responsible for the activities observed.

Conclusion:

Nanosizing of the entire natural products provides an interesting alternative to solvent
extraction as it results in the liberation of active ingredients and certain additional activities. The
resulting nanosuspensions can be investigated further and optimized for applications in Nutrition,
Agriculture, Medicine, and Cosmetics.
Formulation and Evaluation of Isabgol and Liquorice-Based Nutraceuticals Floating Tablets for Management of Gastric Ulcer
Authors: Tiwari Ritesh Kumar , Singh Lalit , Verma Shashi , Sharma Vijay
Published: October 2020

Background:

Floating tablets extend drug residence time, enhance bioavailability and
promote the delivery of local drugs to the stomach. With this objective, floating tablets were
prepared for the treatment of gastric ulcers containing aqueous extract of liquorice and Isabgol.

Methods:

Tablets containing HPMC K100M (hydrophilic polymer), liquorice extract, sodium
bicarbonate (gas generating agent), talc, and magnesium stearate were prepared using direct
compression method. Physical parameters of formulations such as diameter, thickness, hardness,
friability, weight uniformity, drug content, buoyancy time, dissolution, and the mechanism for drug
release, were assessed. The formulations have been optimized based on buoyancy time and invitro
drug release.

Results:

The diameter of all formulations was in the range 11.310-11.833 mm; thickness was in the
range 4.02-4.071 mm. The hardness ranged from 3.1 to 3.4 kg/cm. All the formulations passed the
USP requirements for friability and uniformity of weight. All tablet formulations had a buoyancy
period of less than 5 min and throughout the research, the tablet stayed in floating condition. All
tablet formulations were accompanied in drug discharge by zero-order kinetics and Korsmeyer-
Peppas model.

Conclusion:

It was discovered that the optimized formulation was F7, which released 98.5 percent
of the drug in 8 hr. in-vitro, while the buoyancy time was 3.5 min. For gastroretentive drug
delivery systems, formulations containing Isabgol, sodium bicarbonate and HPMC K100 M in
combination may be promising.
National Security and Human Rights in International Law
Authors: Morris P. Sean
Published: October 2020

The post war-on-terror era has witnessed several developments in international law, including the nature and function of national security. This article establishes a link between national security and human rights by looking at some practical implications from a State policy perspective and theoretical views. Any discussion on the two distinct areas of ‘national security’ and ‘human rights’ are, of course, not equal. However, the discussions in this article relate to how international law interacts with national security over human rights given that national security relates to a State’s domestic affairs but with implications for the international legal system. Thus, through theory and practice, this article demonstrates that national security and human rights are unstable. This article addresses the question of whether national security and human rights obligations are in conflict or whether international law has been over-responsive or under-responsive to either human rights or national security concerns.
Facing the Future: The Case for A Right to a Healthy Environment for Future Generations under International Law
Authors: Greaves Siew Jochelle
Published: October 2020

This paper seeks to examine whether the current framework of international human rights law formally grants the right to a healthy environment to future generations. There has been much debate regarding the effectiveness of international human rights law in guaranteeing environmental sustainability in particular without the consideration of future generations. The right to a healthy environment was specifically chosen both as a means of narrowing the scope of this research and given that future generations are a fundamental concept of international law relating to environmental sustainability. In Section II, all relevant concepts, including ‘future generations’, ‘intergenerational justice and ‘environmental sustainability’ will be defined and explored. In addition, a link will be established between intergenerational equity and sustainable development in light of current literature and scholarly discussion. The following section discusses how the link drawn between environmental protection, human rights protection and environmental sustainability provides for a common approach to fully handling current environmental issues. Subsequently, a positive analysis of present day international legal instruments, customary international law and case law will be conducted, to determine the current status of future generations regarding the right to a healthy environment. Use will also be made of academic literature on the subject, including extensive research carried out by scholars such as Edith Brown Weiss and Bridgit Lewis. To conclude, the findings of each section will be summarised, and a final conclusion will be drawn as to the state of future generations in international law and the potential for the right to a healthy environment to be accorded to them.
Analisis Perbandingan Metode Pengelasan untuk Mengendalikan Distorsi dan Tegangan Sisa – Review
Authors: Wibowo Heri
Published: October 2020

Distortion and residual stress can have undesirable effects on weldments, such as repair work and higher fabrication costs. This study compares welding methods in reducing distortion and residual stress to obtain advantages and disadvantages. The study focused on reviewing several journals from previous research that focused on comparing welding methods. The results show that the Dynamically Controlled Low-Stress No Distortion (DC-LSND) welding method has the most significant ability to reduce distortion and residual stress and does not reduce the weld joint's fatigue resistance. The welding methods of static thermal tensioning (STT) and Transient thermal tensioning (TTT) can significantly decrease distortion and residual stress.  They can improve the fatigue resistance of welded joints. The Double Side Arc Welding (DSAW) method effectively reduces distortion. However, the application in large construction welds is difficult to achieve. Distorsi dan tegangan sisa memberikan pengaruh yang tidak diinginkan pada pengelasan seperti perlunya pekerjaan perbaikan dan meningkatnya biaya fabrikasi. Tujuan penelitian adalah membandingkan metode pengelasan untuk mereduksi distorsi dan tegangan sisa untuk memperoleh kelebihan dan kekurangan. Metode penelitian dilakukan dengan review beberapa literatur jurnal hasil penelitian sebelumnya yang difokuskan pada perbandingan metode pengelasan dalam mereduksi distorsi dan tegangan sisa. Hasil penelitian menunjukkan metode las dynamically controlled low stress no distortion (DC-LSND) memiliki kemampuan mereduksi distorsi dan tegangan sisa paling efektif dan tidak menurunkan ketahanan fatik sambungan las, metode las static thermal tensioning (STT) dan transient thermal tensioning (TTT) memiliki kemampuan mereduksi distorsi dan tegangan sisa dengan signifikan serta mampu meningkatkan ketahanan fatik sambungan las, metode las doublé side arc welding (DSAW) efektif mereduksi distorsi namun sulit diterapkan pada pengelasan konstruksi yang besar.
Desain Portable Android Thermometer Fever (Prometer): Termometer Non-Kontak Praktis Berbasis Android
Authors: Setyawan Bima Agung , Agustianto Tiar , Achmad Widodo Syukri Fathudin
Published: October 2020

Vocational education plays an essential role in the corona pandemic case because it is a direct benchmark for applying science to a cultured society's environment. One of the applications is the development of tools to prevent the spread of COVID-19. The idea arises from the fact that gun thermometers, which are a vital tool to prevent pandemic spread, were scarce and expensive. The proposed solution was to develop a device called Portable Android Thermometer Fever (PROMETER), a suitable non-contact thermometer based on Android. The method was research and development.  Data were analyzed using a qualitative descriptive approach. From the study results, it can be concluded that the PROMETER can be used as an accurate and practical gun-type thermometer.Pendidikan kejuruan mengambil peran penting dalam kasus pandemi corona karena pendidikan kejuruan menjadi tolak ukur pengaplikasian langsung ilmu-ilmu untuk dapat dimanfaatkan dalam lingkungan masyarakat yang berbudaya. Salah satu pengaplikasian ilmu teknologi dalam pendidikan kejuruan yakni dengan pembuatan alat atau sistem sebagai bentuk solusi pencegahan penyebaran covid-19. Dari studi kasus tentang kelangkaan dan mahalnya termometer tembak yang menjadi alat penting dalam penanganan kasus penyebaran covid-19 didapat suatu gagasan desain alat yang diberi nama Portable Android Thermometer Fever (PROMETER): Termometer  Non-Kontak Praktis Berbasis Android Sebagai Alat Pemantau Suhu Badan Dalam Penanggulangan Penyebaran Covid-19. Bentuk penelitian ini adalah research and development. Dari data hasil penelitian diperoleh data yang dianalisis secara kualitatif deskriptif. Dari hasil penelitian dapat ditarik kesimpulan bahwa Portable Android Thermometer Fever (Prometer)dapat digunakan sebagai termometer tembak yang akurat dan praktis.
A evolução do sistema jurídico segundo a teoria dos sistemas sociais de Niklas Luhmann: a temática da resiliência
Authors: Martins Michelle Fernanda
Published: October 2020

Na sociedade contemporânea, o direito enfrenta sérios desafios, dentre os quais regulamentar o convívio social dentro de uma realidade que está em constante transformação. Novas alternativas precisam ser pensadas para que, dentro desse contexto, o acesso à justiça seja garantido, as expectativas normativas dos indivíduos sejam atendidas e o direito evolua. Porém, embora algumas alternativas sejam pensadas, como, por exemplo, a audiência preliminar do Código de Processo Civil de 1973, estas, algumas vezes, sofrem resistências por parte dos atores jurídicos, o que pode impedir a evolução do sistema jurídico. Assim sendo, o presente artigo analisa, dentro de uma perspectiva luhmanniana, a evolução do sistema jurídico, objetivando compreender este processo. Aborda ainda a necessidade de pensar um "direito resiliente", o qual seja capaz de produzir comunicações eficazes em uma realidade tão dinâmica quanto a atual.
O coletivo “Advogados Ativistas” em São Paulo: identidade profissional, comunicação e patrocínio dos assistidos da Geração Y e dos direitos de terceira geração
Authors: Ferreira Marcelo Costa Ferreira
Published: October 2020

Este artigo estuda a questão do acesso a Justiça no Brasil através de um estudo de caso acerca o coletivo “Advogados Ativistas” nos anos de 2014, 2015 e no primeiro semestre de 2016. O objetivo é analisar a identidade profissional enquanto advogados na atuação no município de São Paulo junto as manifestações contra a Copa do Mundo no Brasil, a interação com os coletivos “Organismo Parque Augusta” e “Ocupação Casa Amarela” em prol, respectivamente, da criação de um parque e da manutenção de um ateliê cultural num casarão pertencente ao Governo Federal. As fontes de dados são as redes sociais, a internet e a observação participante com combinação de técnicas qualitativas e documentais. As principais conclusões são a identidade mista enquanto advogados por terem ao mesmo tempo características da Advocacia Tradicional e da Advocacia de causa de ultra vanguarda em termos de defesa de direitos difusos e coletivos, manifestando se também uma contraposição muito clara entre a cultura Pós Materialista – horizontalidade, informalidade, uso intensivo de internet e redes sociais; dos ativistas em relação a cultura materialista – favorável a hierarquia, religião e família; além disto, o Estado Paulista tem uma identidade cultura de caráter coletivo, enquanto os ativistas têm identidades muito individuais na qual a comunicação em rede por celular faz parte da sua identidade pessoal.
Evaluating the Impact of a Risk Assessment System With Tailored Interventions in Germany: Protocol for a Prospective Study With Matched Controls
Authors: Pijl Marten , op den Buijs Jorn , Landgraf Andreas
Published: October 2020

Background

With a worldwide increase in the elderly population, and an associated increase in health care utilization and costs, preventing avoidable emergency department visits and hospitalizations is becoming a global priority. A personal emergency response system (PERS), consisting of an alarm button and a means to establish a live connection to a response center, can help the elderly live at home longer independently. Individual risk assessment through predictive modeling can help indicate what PERS subscribers are at elevated risk of hospital transport so that early intervention becomes possible.

Objective

The aim is to evaluate whether the combination of risk scores determined through predictive modeling and targeted interventions offered by a case manager can result in a reduction of hospital admissions and health care costs for a population of German PERS subscribers. The primary outcome of the study is the difference between the number of hospitalizations in the intervention and matched control groups.

Methods

As part of the Sicher Zuhause program, an intervention group of 500 PERS subscribers will be tracked for 8 months. During this period, risk scores will be determined daily by a predictive model of hospital transport, and at-risk participants may receive phone calls from a case manager who assesses the health status of the participant and recommends interventions. The health care utilization of the intervention group will be compared to a group of matched controls, retrospectively drawn from a population of PERS subscribers who receive no interventions.

Results

Differences in health care utilization and costs between the intervention group and the matched controls will be determined based on reimbursement records. In addition, qualitative data will be collected on the participants’ satisfaction with the Sicher Zuhause program and utilization of the interventions offered as part of the program.

Conclusions

The study evaluation will offer insight into whether a combination of predictive analytics and case manager-driven interventions can help in avoiding hospital admissions and health care costs for PERS subscribers in Germany living at home independently. In the future, this may lead to improved quality of life and reduced medical costs for the population of the study.

Trial Registration

Deutsches Register Klinischer Studien (DRKS), DRKS00017328; https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00017328

International Registered Report Identifier (IRRID)

DERR1-10.2196/17584
Diagnostic Accuracy of Web-Based COVID-19 Symptom Checkers: Comparison Study
Authors: Munsch Nicolas , Martin Alistair , Gruarin Stefanie , Nateqi Jama , Abdarahmane Isselmou , Weingartner-Ortner Rafael , Knapp Bernhard
Published: October 2020

Background

A large number of web-based COVID-19 symptom checkers and chatbots have been developed; however, anecdotal evidence suggests that their conclusions are highly variable. To our knowledge, no study has evaluated the accuracy of COVID-19 symptom checkers in a statistically rigorous manner.

Objective

The aim of this study is to evaluate and compare the diagnostic accuracies of web-based COVID-19 symptom checkers.

Methods

We identified 10 web-based COVID-19 symptom checkers, all of which were included in the study. We evaluated the COVID-19 symptom checkers by assessing 50 COVID-19 case reports alongside 410 non–COVID-19 control cases. A bootstrapping method was used to counter the unbalanced sample sizes and obtain confidence intervals (CIs). Results are reported as sensitivity, specificity, F1 score, and Matthews correlation coefficient (MCC).

Results

The classification task between COVID-19–positive and COVID-19–negative for “high risk” cases among the 460 test cases yielded (sorted by F1 score): Symptoma (F1=0.92, MCC=0.85), Infermedica (F1=0.80, MCC=0.61), US Centers for Disease Control and Prevention (CDC) (F1=0.71, MCC=0.30), Babylon (F1=0.70, MCC=0.29), Cleveland Clinic (F1=0.40, MCC=0.07), Providence (F1=0.40, MCC=0.05), Apple (F1=0.29, MCC=-0.10), Docyet (F1=0.27, MCC=0.29), Ada (F1=0.24, MCC=0.27) and Your.MD (F1=0.24, MCC=0.27). For “high risk” and “medium risk” combined the performance was: Symptoma (F1=0.91, MCC=0.83) Infermedica (F1=0.80, MCC=0.61), Cleveland Clinic (F1=0.76, MCC=0.47), Providence (F1=0.75, MCC=0.45), Your.MD (F1=0.72, MCC=0.33), CDC (F1=0.71, MCC=0.30), Babylon (F1=0.70, MCC=0.29), Apple (F1=0.70, MCC=0.25), Ada (F1=0.42, MCC=0.03), and Docyet (F1=0.27, MCC=0.29).

Conclusions

We found that the number of correctly assessed COVID-19 and control cases varies considerably between symptom checkers, with different symptom checkers showing different strengths with respect to sensitivity and specificity. A good balance between sensitivity and specificity was only achieved by two symptom checkers.
Performance of Digital Contact Tracing Tools for COVID-19 Response in Singapore: Cross-Sectional Study
Authors: Huang Zhilian , Guo Huiling , Lee Yee-Mun , Ho Eu Chin , Ang Hou , Chow Angela
Published: October 2020

Background

Effective contact tracing is labor intensive and time sensitive during the COVID-19 pandemic, but also essential in the absence of effective treatment and vaccines. Singapore launched the first Bluetooth-based contact tracing app—TraceTogether—in March 2020 to augment Singapore’s contact tracing capabilities.

Objective

This study aims to compare the performance of the contact tracing app—TraceTogether—with that of a wearable tag-based real-time locating system (RTLS) and to validate them against the electronic medical records at the National Centre for Infectious Diseases (NCID), the national referral center for COVID-19 screening.

Methods

All patients and physicians in the NCID screening center were issued RTLS tags (CADI Scientific) for contact tracing. In total, 18 physicians were deployed to the NCID screening center from May 10 to May 20, 2020. The physicians activated the TraceTogether app (version 1.6; GovTech) on their smartphones during shifts and urged their patients to use the app. We compared patient contacts identified by TraceTogether and those identified by RTLS tags within the NCID vicinity during physicians’ 10-day posting. We also validated both digital contact tracing tools by verifying the physician-patient contacts with the electronic medical records of 156 patients who attended the NCID screening center over a 24-hour time frame within the study period.

Results

RTLS tags had a high sensitivity of 95.3% for detecting patient contacts identified either by the system or TraceTogether while TraceTogether had an overall sensitivity of 6.5% and performed significantly better on Android phones than iPhones (Android: 9.7%, iPhone: 2.7%; P<.001). When validated against the electronic medical records, RTLS tags had a sensitivity of 96.9% and specificity of 83.1%, while TraceTogether only detected 2 patient contacts with physicians who did not attend to them.

Conclusions

TraceTogether had a much lower sensitivity than RTLS tags for identifying patient contacts in a clinical setting. Although the tag-based RTLS performed well for contact tracing in a clinical setting, its implementation in the community would be more challenging than TraceTogether. Given the uncertainty of the adoption and capabilities of contact tracing apps, policy makers should be cautioned against overreliance on such apps for contact tracing. Nonetheless, leveraging technology to augment conventional manual contact tracing is a necessary move for returning some normalcy to life during the long haul of the COVID-19 pandemic.
Selecting Mobile Health Technologies for Electronic Health Record Integration: Case Study
Authors: Shaw Ryan , Stroo Marissa , Fiander Christopher , McMillan Katlyn
Published: October 2020

Mobile health (mHealth) technologies, such as wearable devices and sensors that can be placed in the home, allow for the capture of physiologic, behavioral, and environmental data from patients between clinic visits. The inclusion of these data in the medical record may benefit patients and providers. Most health systems now have electronic health records (EHRs), and the ability to pull and send data to and from mobile devices via smartphones and other methods is increasing; however, many challenges exist in the evaluation and selection of devices to integrate to meet the needs of diverse patients with a range of clinical needs. We present a case report that describes a method that our health system uses, guided by a telehealth model to evaluate the selection of devices for EHR integration.
Quality of Life, Physical Activity Level and Psychological Profile of Nigerians with Serious Mental Illness and Healthy Psychotropic Naive Subjects (Preprint)
Authors: Okonkwo Christian Arinze , Ibikunle Peter Olarenwaju , Nwafor Izuchukwu , Orovwigho Andrew
Published: October 2020

BACKGROUND

Quality of life (QoL), physical activity (PA) level and psychological profile (PF) of patients with serious mental illness have been neglected during patient’s management

OBJECTIVE

The purpose of this study was to determine the effect of selected psychotropic drugs on the QoL, PA level and PF of patients with serious mental illness

METHODS

A cross sectional survey involving one hundred and twenty-four subject [62 Serious Mental Illness (SMI) and 62 apparently healthy subjects as control] using purposive and consecutive sampling respectively .Questionnaires for each of the constructs were administered to the participants for data collation. Analysis of the data was done using non parametric inferential statistics of Mann-Whitney U independent test and Spearman’s rho correlation with alpha level set as 0.05.

RESULTS

Significant difference was recorded in the QoL (p<0.05) of patient with SMI and apparently healthy psychotropic naive participants. There was a significant correlation between the QoL (p<0.05) and PF of participants with SMI. Participants with SMI had significantly lower QoL than apparently healthy psychotropic naive subject. QoL of the healthy psychotropic naive group was better than those of the participants with SMI. Female participants with SMI had higher PA than their male counterparts

CONCLUSIONS

Psychological profiles of male participants with SMI were lower than male healthy psychotropic naive participants. Clinicians should take precaution to monitor the QoL, PA level and PF because the constructs are relevant in evaluation of treatment outcome.
Angelone, Erik, Maureen Ehrensberger-Dow and Gary Massey (eds). The Bloomsbury Companion to Language Industry Studies
Authors: Guerra Cristian
Published: October 2020

Angelone, Erik, Maureen Ehrensberger-Dow and Gary Massey (eds). The Bloomsbury Companion to Language Industry Studies. Bloomsbury Academic, 2020. 406 pp.. The Bloomsbury Companion to Language Industry Studies. Bloomsbury Academic, 2020. 406 pp.
РЕШЕНИЯ ПО ВКЛЮЧЕНИЮ СРЕДСТВ ЗАЩИТЫ ИНФОРМАЦИИ В ВЫЧИСЛИТЕЛЬНЫЕ КОМПЛЕКСЫ НА ОСНОВЕ ПЛАТФОРМЫ «ЭЛЬБРУС»
Authors: Бычков И.Н. , Лобанов И.Н. , Молчанов И.А.
Published: October 2020

Рассмотрен подход к созданию вычислительных комплексов на основе типовых решений, включающих средства защиты информации. Проработаны решения по включению таких вычислительных комплексов в систему управления информационной безопасностью. Представлены средства вычислительной техники для обработки информации ограниченного доступа.
ГИБРИДНАЯ ТЕХНОЛОГИЯ ПРОИЗВОДСТВА МНОГОКРИСТАЛЬНЫХ СИСТЕМ В КОРПУСЕ С ОДНОВРЕМЕННЫМ ПРИМЕНЕНИЕМ ТЕХНОЛОГИЙ FLIP-CHIP И WIRE BOND
Authors: Региня С.А. , Ершова Н.Ю. , Луньков П.В.
Published: October 2020

Рассмотрена гибридная технология производства микросборок с одновременным применением технологий Flip-Chip и Wire Bond, отрабатываемая на предприятии индустриального партнера GSNanotech. Описаны особенности основных технологических операций и методов контроля качества на каждом этапе производства.
СЕТЬ SPACEWIRE/SPACEFIBRE КАК ОСНОВА ГЛОБАЛЬНОЙ КОСМИЧЕСКОЙ ИНФРАСТРУКТУРЫ
Authors: Гришин В.Ю. , Еремеев П.М. , Орлов А.В.
Published: October 2020

В статье анализируются тенденции развития глобальных космических группировок. Для обеспечения эффективности таких группировок предлагается создание космической информационной инфраструктуры с бортовым сегментом на основе сети SpaceWire/SpaceFibre.
РАСЧЕТ ЭЛЕКТРИЧЕСКИХ ХАРАКТЕРИСТИК ШИНЫ ПИТАНИЯ ЯДЕР В КОММУТАЦИОННОЙ ПЛАТЕ МИКРОПРОЦЕССОРА
Authors: Воробьев А.С.
Published: October 2020

В работе определены электрические характеристики шины питания ядер микропроцессора. Проведен сравнительный анализ влияния изменений, вносимых в характеристики шины питания на различных участках цепи. С учетом данного анализа представлены решения по выбору оптимальных решений для проектирования шины питания ядер в коммутационной плате корпуса микропроцессора.
ТИПОРЯД ВЫЧИСЛИТЕЛЬНЫХ МОДУЛЕЙ НА ОСНОВЕ ПРОЦЕССОРОВ «ЭЛЬБРУС»
Authors: Юрлин С.В.
Published: October 2020

В данной статье приведено описание текущего типоряда вычислительных модулей на основе процессоров «Эльбрус» в сравнении с импортными аналогами, раскрыты аспекты реализации платформы «Эльбрус».
ВЫСОКОУРОВНЕВАЯ СИСТЕМА ПАРАЛЛЕЛЬНОГО ПРОГРАММИРОВАНИЯ СЕТЕЙ МНОГОЯДЕРНЫХ ГИБРИДНЫХ ПРОЦЕССОРОВ
Authors: Биконов Д.В. , Бражкин А.А. , Сивцов А.С. , Дементьев В.В. , Черников А.В. , Черников М.С. , Павлов П.А. , Эйсымонт Л.К.
Published: October 2020

Рассматриваются многопроцессорные узлы суперкомпьютеров на базе процессоров-ускорителей GPU Ampere, Gaudi и Colossus, а также варианты таких узлов с процессорами-ускорителями NM6408MP и расширение библиотеки управления процессами и их взаимодействиями (БУПВ/М), ранее разработанной для одного NM6408MP.
ANALYSIS OF INFLUENCE CLIMATE FACTORS OF THE FAR NORTH ON MORBIDITY OF OPHTHALMIC PROFILE AMONG THE CHILDREN’S POPULATION OF THE ARCHIPELAGO NEW LAND
Authors: Mishin I. Yu. , Doktorova T. A.
Published: October 2020

Purpose. To conduct a study of the impact of the Arctic climate on the organ of vision. The results of the study show a high incidence rate according to the ophthalmic profile among the children of the New Land archipelago.

Conclusion. Practical recommendations for preventing the development of diseases of the organ of vision in children living in the Arctic are offered.
ANALYSIS OF CENTRAL SELF-FUNCTIONS AS PREDICTORS OF ADAPTATION IN NAVAL SPECIALISTS FROM DIFFERENT AGE GROUPS
Authors: Soshkin P. A. , Belov V. G. , Zabrodskyi D. S.
Published: October 2020

Introduction. The study of the central self-functions, manifested by an integral system of forms of mental activity, is highly relevant in terms of optimizing the adaptation of naval specialists.

Purpose: to assess the central self-functions as predictors of adaptation in naval specialists from different age groups.

Materials and methods. 159 naval specialists were examined, divided into 3 age groups — group 1 (n=33) — persons aged 25 to 30 years, group 2 (n=68) — persons aged 31 to 40 years, and the third group (n=58) — persons aged 41 to 45 years, whose central self-functions were studied using Ammon’s self-structural test.

Results and discussion. It has been established that the constructive central I-functions of naval specialists contribute to the optimization of the adaptation of naval specialists, while the destructive central I-functions prevent this. The deficient central self-functions of naval specialists occupy an intermediate position between constructive and destructive indicators.

Conclusion. To optimize the adaptation of naval specialists, it is advisable to carry out corrective measures aimed at shifting the central self-functions towards design indicators.
FEATURES OF SURGEON TRAINING IN A MEDICAL COLLEGE
Authors: Zakrevsky Yu. N. , Duberman B. L. , Mizgirev D. V. , Dynkov S. M. , Bragin V. A. , Oblitsova Z. G.
Published: October 2020

The aim of the study was the assessment of features of surgeon training in the Department of Surgery at the Northern State Medical University of the Ministry of Healthcare of the Russian Federation. The analysis results revealed some methods and procedures that are used for teaching departmental surgery, issues of organization of Students’ Individual Work have been considered. Special focus was on the study of methods of interactive learning of surgical sciences, in particular, on simulation education. Features of practical studies combined with individual work (follow-up of patients, case history filling, research of material for case studies) were emphasized. Benefit of written examination for checking the capability of educand to apply gained knowledge in solving specific clinical issues.
FANSUR SEBAGAI KOTA TUA ISLAM
Authors: McKinnon E. Edwards , Nurdin AR
Published: October 2020

Fansur is an ancient Islamic city in Nusantara (the Indonesian archipelago) which was very popular in the past. However, the specific location of the city is still being debated today. Generally, contemporary writers state that Fansur is located in Barus, one of the areas in Central Tapanuli, North Sumatra. This opinion has been challenged from several authoritative sources. To solve the above problems, this research was conducted through an archaeological approach and literature study. Based on archaeological evidence and written sources, Fansur City is located in Lhok Pancu or Lhok Lambaroneujid, one of the coastal areas to the west of the city of Banda Aceh, Aceh. This location fits perfectly with the character of the Fansur location mentioned in ancient records from the Middle East, China and Europe. Due to geological changes that have occurred frequently in the past in the Aceh region, most of the area has been lost and cannot be seen again. The remains of ancient ceramics, tombstones and ancient tomb complex (diway) are archaeological evidence to strengthen the argument that Fansur is an ancient Islamic port city located in the Aceh Besar region, not in Barus, Central Tapanuli.
NANDONG: TRADISI LISAN SIMEULUE
Authors: Ismail Sanusi , Abubakar Bustami , Hasbullah  , Aiyub Azhari
Published: October 2020

Simeulue, located in the Indian Ocean, has attracted a lot of people’s attention after the tsunami hit the region in 2004. The low number of casualties in Simeulue compared to other affected made the island a spotlight for further research. Some people argue that some forms of oral traditions exist among the people of Simeulue have played a role in saving many lives from the impact of the disaster. Nandong is a popular oral tradition in Simeulue. This oral tradition is important and considered as local wisdom because it contains norms and values inherited by the Simeulue community from generation to generation. This article aims to explore the substance and existence of this local wisdom in the Simeulue community. This study was conducted using qualitative methods. Our research data were collected during fieldwork through interviews, participant-observation and archival reviews. This research found that nandong is a distinctive oral tradition that is different from other oral traditions exist in Simeulue such as buai, nanga-nanga, tokok-tokok and nafi-nafi. This study argues that nandong is the most influential oral tradition among the Simeulue community. Unfortunately, the future existence of nandong in Simeulue is at risk of extinction since not many people, especially the young generation, in Simeulue today eager learn the rich and profound teachings contained in nandong.
Educomunicação e autoetnografia: diálogos e aproximações
Authors: Melo Teresa Mary Pires de Castro , Camargo André Luiz Rodrigues de
Published: October 2020

Este artigo tem por objetivo refletir sobre as aproximações entre a Educomunicação e a Autoetnografia. A primeira, um conceito e a segunda, uma metodologia, que dialogam entre si por um elemento comum: o processo. Como introdução ao tema trazemos a ideia de Comunicação como um direito humano - por meio de Murilo Ramos, que chama a atenção para a “mudança de perspectiva” da Comunicação. Para apresentar a Educomunicação estaremos ao lado de pensadores basilares do conceito: Paulo Freire, Mário Kaplún, assim como de Grácia Lopes Lima, que destaca o processo como fundamento da prática educomunicativa. Para pensar a Autoetnografia estaremos amparados nas leituras de Scribano e De Sena, Heewon Chang e Rodrigo Alberto Lopes.
Zeitgeist À Direita: O Viés Neoliberal Dos Movimentos Conservadores E Sua Influência Na Definição de Políticas Públicas
Authors: Azevedo Junior Ary de Castro
Published: October 2020

ResumoO crescimento de movimentos conservadores baseados em valores neoliberais, que reduzem a relevância do Estado ao propor a substituição de variados serviços públicos,  oferecidos por entidades governamentais,  por empresas privadas, segue um roteiro baseado na redução de direitos sociais e na ampliação da  área de atuação de organizações privadas, que agora ocupam o espaço antes restrito a órgãos públicos.  Isto é realizado através de ações coordenadas por organizações (think tanks) que influenciam a opinião pública e a classe política. Para entender esse processo, foram realizadas pesquisas exploratórias, de caráter documental, indicando a forma de atuação destas organizações no agendamento da mídia e, conseqüentemente, influenciando a opinião da sociedade, a fim de naturalizar a substituição de serviços públicos por serviços privatizados.
Conservadorismo acima de tudo e de todos: imaginários sociodiscursivos nos discursos de posse presidencial de 2019
Authors: Ramalho Procópio Xavier Mariana , João Vieira Filho Maurício
Published: October 2020

Este artigo tem como objetivo identificar e analisar como são construídas as representações para o Brasil, os brasileiros, o governo e o presidente nos discursos de posse presidencial de 2019. Para isso, utiliza-se como repertório teórico-metodológico a análise do discurso, notadamente a Teoria Semiolinguística, de Patrick Charaudeau, com destaque para o conceito/categoria analítica dos imaginários sociodiscursivos. Nos pronunciamentos, constata-se que Bolsonaro mobiliza os imaginários sociodiscursivos relacionados à religião para se apresentar como salvador e messias; imaginários de corrupção e criminalidade para referir ao Brasil; imaginários de cidadão de bem e de mal para os brasileiros; e imaginários de libertação e futuro promissor para seu governo. Além de apresentar ataques aos governos anteriores, valores conservadores que nortearão seu mandato e retoma o fato de ter sobrevivido a uma facada.
Do jornalismo informativo ao de posição: a “guinada à direita” do jornal Gazeta do Povo
Authors: Tavares Camilla Quesada
Published: October 2020

Este artigo busca explicar o processo de reconfiguração editorial do jornal mais antigo em circulação do Paraná, a Gazeta do Povo, consolidado em 2017. Criado em 1919, o veículo é um dos mais tradicionais do estado e foi pioneiro em diversas frentes editoriais ao longo do século XX, ações que renderam prêmios e reconhecimento aos seus jornalistas. Mas, com este novo projeto, a edição impressa diária foi encerrada e uma nova linha editorial implementada. A partir disso, o jornal abdicou de uma concepção mais informativa de jornalismo e adotou uma perspectiva politicamente alinhada. De modo complementar, propomos uma reflexão acerca dessas mudanças e o que elas representam para o jornalismo. Argumentamos que o novo projeto editorial, associado ao contexto político-social, levaram a Gazeta do Povo a uma “guinada à direita”, tornando-se um veículo de posição e representante do conservadorismo brasileiro.
Evaluasi Dosis Fraksionasi Sinar Gamma dalam Melemahkan Parasit Malaria Plasmodium berghei pada Mencit untuk Pengembangan Vaksin Iradiasi
Authors: Syaifudin Mukh , Mahmudah Hartati , Kisnanto Teja , Tetriana Devita , Nurhayati Siti , Nurhayati Tur , Rahardjo Tur , Darliana Darliana
Published: October 2020

Abstract

Malaria is still a big problem in Indonesia so that the development of vaccine is urgently needed. However, the immunity is not fully obtained in host that may be due to high dose of irradiation to parasites. This study aimed to determine the infectiveness of Plasmodium berghei malaria parasite in mice after being irradiated with gamma fractionated dose of 0 Gy, 100+50, 100+75 and 100+100 Gy at a dose rate of 717 Gy/h. Observation of the percentage of parasitic appearance forms (parasitemia) such as trophozoite (including ring) and schizont was done on thin blood smears stained by Giemsa from observation day 2 to 20 post injection. The results showed that fractionated irradiation was effectively suppressed the growth of parasites in the blood of mice for all treatment groups except the fractionation dose of 100+75 Gy. Mice injected with a dose of 100+100 Gy have a stable body weight during days of observation, supported by a relatively normal macroscopic appearance of the liver and spleen. It was concluded that fractionated dose of 100+100 Gy is most effectively weakened the parasite for malaria vaccine material supported by body weight stability and better condition of liver-lymph organ.

AbstrakMalaria masih merupakan pemasalahan besar di Indonesia sehingga pengembangan vaksin sangat diperlukan. Akan tetapi, imunitas pada inang belum sepenuhnya diperoleh yang kemungkinan disebabkan oleh tingginya dosis iradiasi pada parasit. Penelitian ini bertujuan untuk mengetahui daya infektif parasit malaria Plasmodium berghei pada mencit setelah diiradiasi gamma fraksinasi 0 Gy, 100+50, 100+75 dan 100+100 Gy pada laju dosis 717 Gy/jam. Diamati persentase kemunculan bentuk-bentuk parasit (parasitemia) seperti tropozoit (termasuk cincin) dan skizon pada apusan darah tipis yang diwarnai Giemsa, dari hari pengamatan ke-2 hingga 20 pasca penyuntikan. Hasil penelitian menunjukkan bahwa iradiasi fraksinasi efektif menekan pertumbuhan parasit dalam darah mencit untuk semua perlakuan kecuali dosis fraksinasi 100+75 Gy. Mencit disuntik dosis 100+100 Gy memiliki berat badan yang stabil selama pengamatan, didukung oleh tampilan makroskopis hati dan limpa yang relatif normal. Disimpulkan bahwa iradiasi fraksinasi 100+100 Gy paling efektif melemahkan parasit sebagai bahan vaksin malaria, didukung oleh kestabilan berat badan dan kondisi organ hati-limpa yang lebih baik.