bluuebunny/crossref_metadata_2025 huggingface dataset:
Polar Vortex Disruptions by High Latitude Ocean Warming
Authors: Hamouda Mostafa E , Portal Alice , Pasquero Claudia
Published: January 2024

Mid-latitude extreme cold outbreaks are associated with disruptions of
the Polar Vortex, which often happen abruptly in connection to a Sudden
Stratospheric Warming. Understanding Global Warming (particularly Arctic
Amplification) impacts on forecasting such events is challenging for the
scientific community. Here we apply clustering analysis on the Northern
Annular Mode to identify surface precursors and the governing mechanisms
causing polar vortex disruption events. Two clusters of breakdown
emerge; 65% of the events are associated with high latitude ocean
warming, expressed as North Pacific anomalies and Barents-Kara sea ice
loss. Such warming causes large scale modifications of the tropospheric
flow that favors a slowdown of the stratospheric vortex. The persistence
of ocean surface temperature patterns allows forecasting polar vortex
disruptions, and potentially improves prediction skills at the
sub-seasonal to seasonal time scales.
Characterizing Natural Hydrogen Occurrences in the Paris Basin Using OCR-Enhanced Well Database Studies
Authors: Lefeuvre Nicolas , Thomas Eric , Truche Laurent , Donzé Frédéric-Victor , Cros Thibault , Dupuy Johann , Pinzon-Rincon Laura Alejandra , Rigollet Christophe
Published: January 2024

This study investigates natural hydrogen (H2) occurrences in the Paris
Basin, using Optical Character Recognition (OCR) technology to analyze
an extensive, yet historically underexploited, well database that
contains older drilling records. With the growing demand for carbon-free
energy, natural hydrogen, produced through processes like
serpentinization and water radiolysis, offers a promising alternative to
fossil fuels. However, its potential has been largely unexplored in
conventional oil and gas wells. Utilizing the BEPH (Office of
Exploration and Production of Hydrocarbons) French database, which
includes well logs, mudlogs, and End Drilling Reports (EDRs) in PDF
image format, we applied the Tesseract-OCR Engine to convert these
documents into searchable formats for efficient data analysis. Our
analysis revealed several H2-bearing wells across the French sedimentary
basins. The hydrogen occurrences in the Aquitaine Basin correlate with
the geological context, but those in the Paris Basin present an anomaly,
as their H2 occurrences do not align with the expected geological
factors. In the Paris Basin, H2 has been detected in four main
formations: the Lusitanian aquifer, Dogger aquifer, Triassic aquifer,
and the basement. The highest hydrogen concentration (52 vol%) was
found in the Dogger formation. These wells are primarily located along
the Bray fault and thrust, indicating a geological influence on H2
distribution. This research demonstrates the effectiveness of OCR in
reprocessing historical drilling data for natural hydrogen exploration,
highlighting the need for comprehensive exploration methodologies in
this emerging field.
Structural modeling, expression and purification of Chimeric chitinase 42 containing His-tag in Nicotiana tabacum hairy root system
Authors: Soleimani Faranak , Motallebi Mostafa , Zamani Mohammadreza , Jourabchi Esmat
Published: January 2024

Chimeric chitinase42 (Chit42 containing ChBD) has great potential as a
candidate for digesting and recycling chitin as a beneficial nutrient, which
can be produced in bioreactors. The plant is one of the most efficient
bioreactors that can produce the eukaryotic proteins in active forms. With
the plant hairy root system, it is possible to express a variety of
recombinant proteins cost-effectively, easily, and quickly. Due to the huge
amount of proteins in plants, protein purification can be facilitated by the
use of the His-tag. In this research, different computer programs were used
for the three-dimensional structural analysis of Chimeric chitinase42
containing His-tag. The results showed that these comparative modeling
approaches had a remarkable degree of accuracy in predicting the fused
protein structure. The Z-score of -9.38 and -3.64 predicted for Chit42 and
ChBD by ProSA represents the good quality of the model. In addition,
bioinformatic observations showed that the His-tag was exposed and can be
used to purify the Chimeric chitinase42. The Chimeric chitinase42 containing
a His-tag was expressed in Nicotiana tabacum hairy roots, and the role of
the His-tag in the detection by Western blot and purification using a Ni-NTA
column was investigated. The presence of the Chimeric chitinase42 was
confirmed by analyzing root extracts using SDS-PAGE and Western blot. The
purification step was achieved using the His-tag and the Ni-NTA column. The
plant-derived Chimeric chitinase42 was confirmed to be biologically active
by measuring the chitinase activity of the purified protein on a media plate
containing colloidal chitin.
The festival of Dalmatian klapa in Omis as an example of the festivalization of Croatian traditional music
Authors: Caleta Josko
Published: January 2024

The term ?folk music? in Croatia is closely related to the history of its
performance at festivals and other related public events. Festivals (smotre)
were an appropriate field of application in the place of canonization of
traditional music. Through their existence and activity, various musical
genres, styles, and performers were profiled. All of the above will be
defined and analyzed through the example that is the focus of this research
- the Festival of Dalmatian klapa in Omis, a festival that formatted,
institutionalized, and popularized klapa singing.
Hanging Out as a Meaningful Occupation
Authors: S* Tri Budi
Published: January 2024

Background: College students undergo a developmental transition from adolescence to adulthood, which can be challenging and make them more vulnerable to mental health problems. Objective: The purpose of this study is to determine the benefits of hanging out as a meaningful leisure occupation to deal with stress in college students and how hanging out can improve the mental health and well-being of college students. Methods: A qualitative phenomenological approach was applied. Data were collected using Focused Group Discussion with eight students who hanging out regularly 1-2 times a week. Results: There were two themes identified in this study: The first theme is hanging out meaningful leisure occupation with three sub-themes namely students’ perception of hanging out, hanging out as leisure among students, and benefits of hanging out as a meaningful leisure occupation. the second theme was the impact of hanging out on students with two sub-themes namely the impact of hanging out on student mental health and the impact of hanging out on student well-being. Conclusion: Hanging out provides many benefits for students, especially to reduce academic stress, and hanging out can have a positive impact on students' mental health and well-being.
Evidence-Based Guideline: Individualized Music for Persons with Dementia (7th Edition) — Non-Pharmacological Intervention for Agitation
Authors: LA Gerdner
Published: January 2024

Individualized music is a non-pharmacological intervention for the management of agitation in persons with dementia. It is supported by the Middle-Range Theory of Individualized Music Intervention for Agitation (IMIA), including testable propositions. The Evidence-Based Guideline: Individualized Music for Persons with Dementia (PWD) was originally published in 1996, has recently been updated and is now in its 7th edition. The current edition is 81 pages in length and includes 144 references. This guideline provides the culmination of over 30 years of research and clinical implementation. The guideline provides a grading schema for the strength and consistency of evidence, with a step-by-step description of the intervention to insure consistency in implementation and evaluation of outcome measures. The intervention is individualized at multiple levels, and is more than simply playing preferred music for the PWD. The intervention emphasizes personhood by including the role of music in the person’s life prior to the onset of cognitive impairment. This includes the role of music in the person’s ethnic identity and religious practice. The intervention has been empirically and clinically tested by scholars in an expanding number of countries. Individualized music is versatile and has been successfully used in home care, adult day care, assisted living, longterm care, post-acute care, and palliative care. As with previous editions, the 7th edition is available, along with all supporting documents and forms, as a free downloadable pdf.
Combined Tumor-A Tumor with Features of Malignant Melanoma and Squamous Cell Carcinoma-A Case Report and Review of Literature
Authors: Shah Pranjal
Published: January 2024

Squamo-melanocytic tumors are very rare. The most common sites are head and neck followed by extremities. It consists of two distinct malignant tumors with epithelial and melanocytic components, hence classified as combined tumor. These tumors represent a diagnostic challenge and histopathological examination plays an important role in early diagnosis as well as treatment. We present a case of combined tumor that is malignant melanoma with squamous cell carcinoma in a 65 year old female patient to highlight its rarity as well as clinical and histomorphological features.
Potential Role of Room Temperature Superconductor LK 99 in MRI and Radiology
Authors: B* Som
Published: January 2024

Magnetic Resonance Imaging (MRI) is a vital diagnostic tool in medical imaging, revolutionizing radiology and enhancing medical diagnoses. The key component enabling MRI is the superconducting magnet, which operates at extremely low temperatures using liquid helium cooling. However, the apparently recent discovery of the room-temperature superconductor LK- 99 if true holds the potential to transform MRI technology. If LK-99 can be successfully integrated into MRI machines, it could eliminate the need for cryogenic cooling, resulting in smaller, lighter, and more affordable machines. The higher magnetic fields enabled by LK-99 could enhance image resolution and scanning speed, leading to improved accuracy in diagnoses and better patient outcomes. The unique properties of superconductors, such as zero electrical resistance and perfect diamagnetism, make them ideal for MRI applications, offering enhanced image quality and faster scanning times. The integration of superconductors in MRI technology has already led to significant advancements, including high-field MRI systems and mobile MRI units. However, challenges remain, such as the stability and cost of LK-99 and the development of MRI machines compatible with this new material. Despite these challenges, the potential benefits of LK-99 in MRI machines are promising and could revolutionize medical imaging if successfully implemented. Further research and development are necessary to explore LK-99's capabilities fully
CT Image Quality Assessment by a Channelized Hotelling Observer: Optimization of Adaptive Statistical Iterative Reconstruction for Radiation Dose Reduction and Improving Image Quality of Pediatric Abdominal CT Scan
Authors: A* Chaparian
Published: January 2024

Background: Iterative reconstruction (IR) techniques have tried to reduce the radiation dose of computed tomography (CT) scans while maintaining the image quality. One of the IR techniques is the adaptive statistical iterative reconstruction (ASIR). Increasing the amount of ASIR in image reconstruction can lead to the emergence of artifacts and reduce the ability to detect objects with low contrast. Objective: This study aimed to optimize the ASIR technique to reduce the radiation dose and increase image quality in pediatric abdominal CT. Methods: This is a phantom study performed using variable tube current (40,100,140 and 200mA) and ASIR level (ASIR 10% to ASIR 100%). Various criteria including noise, high-contrast spatial resolution, and Channelized Hotelling observer’s model were used to compare image quality at different captured levels. In this study CHO model was used for low contrast detectability. Results: The result was quit promising in the term of CHO’s used for mentioned purposes. The noise of reconstructed images with 30% ASIR and higher levels had a significant difference compared to the reconstructed images by the Filter Back Projection (FBP) method (P < 0.05). The spatial resolution of the images with tube currents of 140, 100, and 40 mA reconstructed with 30, 50, and 80% levels of ASIR technique was equal to 0.8 ± 0.144 pairs of lines per millimeter. The amount of the spatial resolution of images obtained with standard radiation dose and reconstructed by FBP method was 1 pair of lines per mm (p> 0.05). Conclusion: Based on the results of this study, using 50% ASIR for the pediatric population can reduce the radiation dose on abdominal and pelvic CT scans by 50% while maintaining image quality. Furthermore using ASIR 50% only for the reconstruction of abdominal and pelvic images in children at standard radiation dose leads to optimal image quality.
The Impact of Clinical Features in Radiomics of CT Non-Small Cell Lung Cancer
Authors: G* Gary
Published: January 2024

Purpose: To investigate the impact of clinical features on model performance in CT-based Non-Small Cell Lung Cancer (NSCLC) and the potential uncertainty regarding their application in machine learning. Methods: Clinical and radiomic features were retrospectively retrieved from EMR and CT images of 496 NSCLC patients. Five feature datasets were constructed: radiomic features-only (Rad), clinical features-only (Clin), shape features-only (Shape), radiomic and clinical features (RaClin), shape and clinical features (ShClin). Five feature selection methods and seven predictive models, along with different cohort sizes, number of input features and validation methods were included for the uncertainty analysis, with two-year survival as the study endpoint. AUC values were calculated for comparisons and Kruskal-Wallis testing was performed to determine significant differences. Results: A total of 19740 distinct combinations of feature sets, feature selection methods, predictive models, cohort sizes and validation techniques are examined. Of those, 25 combinations produce an AUC > 0.7. The clinical-only feature dataset generally outperforms both the radiomic-only feature dataset and the hybrid (clinical and radiomic) feature dataset (P<0.01), which is primarily determined by the endpoint. The combination of different feature selection methods and predictive models, along with the variations in cohort size, number of input features and validation methods generate inconsistent results. Conclusion: Clinical features are a source of data that can improve machine learning model performance. However, its impact strongly depends on various factors that may lead to inconsistent results. A clear approach to incorporate clinical features to generate reliable results requires further investigation.
CRISPR-Cas-Based Epigenome Editing as a Novel Therapeutic Strategy for Metabolic Disorders: Targeting Gene Expression Patterns in Specific Tissues to Treat Diabetes and Obesity
Authors: Ahmad Ashfaq
Published: January 2024

Metabolic disorders such as diabetes and obesity are major public health concerns that affect millions of people worldwide. Epigenetic modifications have been implicated in the development and progression of these disorders, making them attractive targets for therapeutic intervention. The emergence of Clustered Regularly-Interspaced Short Palindromic Repeats (CRISPRCas-based) epigenome editing technology has revolutionized the field of gene editing and holds great promise for the treatment of metabolic disorders. However, there are still significant challenges and ethical concerns that must be addressed before this technology can be safely and effectively used in clinical applications. This review provides an overview of epigenetic modifications and their role in metabolic disorders, as well as an explanation of CRISPR-Cas-based epigenome editing and its potential applications. The current state of research and major findings on using this technology for the treatment of metabolic disorders are discussed, along with the advantages and limitations of different delivery strategies. The potential for off-target effects and unintended consequences, as well as strategies for minimizing or mitigating these effects, are also considered. Ethical and regulatory issues associated with CRISPR-Cas-based epigenome editing for metabolic disorders are discussed, with a focus on the importance of responsible development and implementation of this technology. The potential societal impacts of CRISPR-Cas-based epigenome editing for metabolic disorders are also considered. In conclusion, this review highlights the potential of CRISPR-Cas-based epigenome editing as a therapeutic strategy for metabolic disorders, but also underscores the importance of rigorous safety and efficacy testing and responsible implementation. Ultimately, the success of this technology will depend on a balanced consideration of the scientific, ethical, and societal implications.
Macrosomia: A Serious Complication of Diabetes in Pregnancy
Authors: Veerabathiran Ramakrishnan
Published: January 2024

Gestational diabetes mellitus (GDM) and its associated complication, macrosomia, pose significant challenges during pregnancy. This review explores the epidemiological aspects, pathophysiology, complications, and long-term consequences of these conditions, with a focus on the need for early detection and advanced management strategies. The prevalence of GDM varies globally, with particular attention to India, where the correlation between macrosomia and GDM is evident. Early prenatal monitoring and glycemic control have been identified as effective strategies to reduce macrosomia incidence. Understanding the pathophysiology of GDM reveals a complex interplay of β-cell dysfunction and chronic insulin resistance, resulting in elevated blood sugar levels. This disruption contributes to macrosomia, characterized by the birth of abnormally large infants. Complications associated with macrosomia are not limited to childbirth; mothers may experience protracted labor, uterine atony, and an increased risk of tears, while newborns face the challenge of shoulder dystocia and neonatal jaundice. Additionally, the enduring significance of exposure to GDM in utero is concerning, with evidence linking it to childhood obesity and metabolic syndrome. The review also discusses promising research directions. The study of glycation markers aims to improve macrosomia prediction, enabling better management and care for affected pregnancies. Moreover, the integration of mobile technology, such as the GDm health smartphone solution, offers remote monitoring of blood glucose levels and tailored feedback, potentially revolutionizing GDM management. In tackling the challenges presented by GDM and macrosomia, a multifaceted approach is essential. Early and effective prenatal care, coupled with vigilant glycemic control, is critical for the well-being of both mothers and their infants. Continued research into innovative screening and management methods will further enhance pregnancy outcomes and long-term health. Healthcare professionals, armed with a comprehensive understanding of these conditions and their extensive effects, play a pivotal role in supporting expectant mothers and ensuring a brighter and healthier future for both mother and child.
Clinical Study of Diabetes Mellitus with Effectiveness of Homoeopathic Medicine Sulphur, by Managing Diet and Regimen
Authors: S Sheba
Published: January 2024

Diabetes mellitus (DM), universally recognized as diabetes, is a clutch of metabolic disorders categorized by a high blood sugar level over a sustained era. Indicators are high blood sugar include frequent urination, augmented thirst, and amplified hunger. If port unprocessed, diabetes can be a source of numerous snags. Acute hitches can omit diabetic ketoacidosis, hyperosmolar hyperglycaemic state, or demise. Grim of long-term impediments include cardiovascular illness, stroke, chronic kidney disease, foot ulcers, and destruction to the eyes. The chief impartial of our scrutiny is to determine the efficacy of the homoeopathic medicine, Sulphur in managing diabetics mellitus and providing through broad-spectrum administrations are recommended subsequently from side-to-side clinical examination and case taking. Here, five cases analysed by means of diabetics reserved in to deliberation and through this study I intend to portray and delineate the Sulphur medicine spectacles with marked action upon the diabetics with the assortment of similimum and beside by fetching the hilarity of symptoms to underneath resistor and has been substantiated to provoke the deranged vitality in patients with diabetics and bring them ease.
Antidiabetic Therapy in Patients Related to CKD (Chronic Kidney Disease)
Authors: U Bhavana
Published: January 2024

Patients with type 2 diabetes mellitus (T2DM) are more likely to have chronic kidney disease (CKD) in stages 3-5 (glomerular filtration rate [GFR] 60 mL/min) by roughly 25–30%. Despite the limits of most oral anti-diabetic medications in people with CKD, incretin-based treatments are being utilized more frequently to treat type 2 diabetes. This study examines the impact of CKD on the pharmacokinetics of glucagon-like peptide-1 (GLP-1) receptor agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors, as well as the efficacy/safety profile of these medications when used in patients with T2DM and CKD. Sitagliptin, Vildagliptin, Saxagliptin, and Alogliptin are the most common DPP-4 inhibitors that are primarily excreted by the kidneys. This led to recommendations for appropriate dose reductions based on the severity of CKD after pharmacokinetic studies revealed that total exposure to the medication is increased in proportion to the fall in GFR. Clinical investigations found that patients with CKD had a high effectiveness and safety profile under these circumstances. Lintagliptin, on the other hand, is primarily excreted through the hepatobiliary system. No dose adjustment of lintagliptin is necessary in the setting of CKD because a pharmacokinetic investigation revealed that lower GFR had a negligible impact on total exposure. Patients with CKD have less experience using GLP-1 receptor agonists. Exenatide should not be administered to patients with severe CKD because it is excreted through renal processes. Due to the limited experience with CKD patients, ligarglutide should be administered with caution even if the kidneys do not remove it from the body. For lixisenatide, exenatide long-acting release (LAR), and other once-weekly GLP-1 receptor agonists now under development, only scant pharmacokinetic data are also available. GLP-1 receptor agonists have been implicated in several case reports of acute renal failure, which was most likely brought on by dehydration brought on by gastrointestinal side effects. Nevertheless, improving GLP-1 may also have advantageous renal effects that could help lower the incidence of diabetic nephropathy. In conclusion, the physician has new chances due to the DPP-4 inhibitors' broad and encouraging experience in CKD patients, whereas the limited experience with GLP-1 receptor agonists in this population calls for greater caution.
The Direct Cost and Pattern of Anti-Diabetic Therapy among Patients in a Teaching Hospital in a Resource-Poor Setting
Authors: Adesoye Oluwaseun Opeyemi
Published: January 2024

Background: Diabetes Mellitus is a prevalent disease in Sub-Saharan Africa with debilitating effects on health and socioeconomic activities. Payment for health services, such as medications to manage the ailment, remains challenging and worsens a household's access to care. The study's objectives were to determine the direct medical cost of anti-diabetic medications and drug utilization patterns amongst out-patients seeking diabetic care in a tertiary health facility. Methods: A cross-sectional study was conducted among 104 respondents at the endocrinology unit of Delta State University Teaching Hospital, Oghara, from Jul 14 to Nov 30, 2022. The monthly expenditures (total and mean) for drug payments were assessed. The drug prescription pattern was similarly evaluated. Results: The total and mean costs for anti-diabetic medications were N1, 576, 458/ $3,608.69 and N7, 436.07/ $17.02 per month, respectively. All respondents paid out-of-pocket for the drugs provided. The majority of respondents were prescribed metformin. Conclusion: The mean cost of drug treatment of diabetes mellitus amongst respondents at the facility was high and unsustainable, given the economic conditions. Health subsidies in alignment with community-based contributory health insurance will protect the vulnerable financially and improve access to anti-diabetic care.
Use of Umbilical Cord Mesencymal Stem Cells in the Treatment of Severe COVID-19 Pneumonia
Authors: De Vera Michelle Joy
Published: January 2024

A proposed mechanism of severe Corona virus Disease-2019 (COVID-19) is a deregulated innate immune response to an infection with SARS-CoV-2 resulting in cytokine release syndrome (CRS). Mesencymal stem cells (MSC) have been shown to have immunomodulatory effects and may attenuate the CRS. We present 11 cases of severe COVID-19 pneumonia treated with umbilical cord-derived, non-HLA matched MSC administered as four separate intravenous doses, 5×105 cells/kg. Clinical symptoms, measurements of inflammatory mediators and cytokines (IL6, IL10, IFN-γ, TNF-α), and radiological results were recorded for each patient. Although there were large variations in baseline cytokine pattern elevation, all cytokine levels decreased in all patients after the 4 infusions of UC-MSC, albeit in different magnitudes. Seven patients eventually improved in terms of need for supplemental oxygen and/or mechanical ventilation, clinical symptoms, resolution of pneumonia on imaging, and were discharged. Three patients expired, 1 of whom expired before completing the full course of therapy. This limited series of patients showed that UC-MSC therapy down regulates the cytokine storm and may improve clinical status in patients hospitalized with severe COVID-19 pneumonia without any infusion related reaction.
The Use of Botulinum Toxin-A Injection in Medicine and Orthopaedic Surgery
Authors: Gartenberg Ariella
Published: January 2024

Study Design: Literature Review Background: Botulinum toxin A (BTX-A) targets specific muscle groups to block the release of acetylcholine at the neuromuscular junction and, therefore, reduce muscular activation. Through weaking of muscle activity, BTX-A injections have become widely used for cosmetic purposes, as well as the treatment of various neuromuscular disorders including strabismus, movement disorders, and overactive bladder syndrome. Objective: To review the history of BTX-A injections, as well as discuss its current and future cosmetic, medical, and surgical applications. Methods: A comprehensive literature review was performed on the development, application, and efficacy of BTX-A injections in the treatment of various neuromuscular and spinal disorders. Results: Within the orthopaedic spine world, BTX-A injections have effectively been utilized for the treatment of spastic muscular disorders, including spinal cord injuries, cervical spine pain, lower back pain, and scoliosis. By reducing muscular tone, BTX-A injections have shown over 90% reduction in pain after repeated injections. Conclusions: BTX-A is an essential neurotoxin that functions not only through cosmetic application, but also in the treatment of neuromuscular and spinal disorders. Further studies of greater sample size are needed to fully address potential limitations and assess long-term success of such treatment modalities.
Approach of Ayurveda in Attention Deficit Hyperactive Disorder-A Single Case Study
Authors: M Silswal
Published: January 2024

Attention Deficit Hyperactive Disorder (ADHD) is one of the most common neurobehavioral disorders of childhood and often lasts into adulthood. Children with ADHD may have trouble paying behavior’s (may act without thinking about what the result will be) or be overly active. It is normal for children to have trouble focusing and behaving at one time or another. However, children with ADHD do not just grow out of these behaviors. The cause and risk factors for ADHD are unknown, but current research shows that genetics plays an important role. Ayurvedic treatment with therapies aimed at improving brain function, enhance attention and mind calmness along with behavioral therapy, can be very helpful in ADHD.
Personality Development through Ayurveda
Authors: R Sharma
Published: January 2024

Personality is the trait which defines a person. According to Dunham, “Personality distinguishes us from other people and defines our general nature. Our overall personality is composed of a collection of psychological characteristics or traits that determines our personal preferences and individual style of behavior.” This writing suggests that different people exhibit different personalities and that a person’s personality comprises of a set of Physio-psychological characteristics which are determinant of a person’s preferences and his/her individual behavior. In the Indian medical system of Ayurveda, Health is the result of balanced interplay between three functional principles of body which are termed as Sharirika Dosha -Vata, Pitta, and Kapha - that regulate physical functions & Mansika Dosha- Satva, Raja and Tama – that regulate one’s psychological behavior. The relative proportion of these Sharirika & Mansika Doshas in an individual determines the person’s psychophysical constitution which is termed as Prakriti in Ayurveda. Another term, Aachara Rasayana; is a unique concept in Ayurveda that implies moral, ethical, and benevolent conduct which plays an important role in development of personality. An equilibrium state of body, mind, social and spiritual well-being is defined as Health by Ayurveda. To attain this, there has been mentioned certain codes of conduct in Ayurveda which are all together known as Sadvritta (Code of conduct). All these together helps in achieving a better framework of personality according to Ayurveda. Thus, this article aims in finding various prospects that help in development of an individual’s Personality.
Scientific Understanding of Cytokine Storm in Perspective of Ayurveda: A Review
Authors: AK Tanwar
Published: January 2024

Cytokine storm also known as cytokine releasing syndrome is due to elevate level of circulating cytokine and hyper action that can be triggered by some factor like virus, bacteria or other epigenetic factors. In this era of communicable disease, COVID-19 is such a disease which shows manifestation in the form of cytokine storm. Increase level of cytokine like interleukin-6 etc in the blood causes destruction of normally functioning cell leads to dangerous life-threatening condition like ARDs. Cytokines are immunomodulating agents composed of soluble proteins, peptides and glycoproteins secreted by haemopoietic and nonhaemopoietic cells in response to various stimuli. Their main role is in molecular interaction between various cells of the immune system. Cytokines are nothing but just the immune markers which hyperactivation leads to cytokine storm. There is not any description of such pathogenesis in Ayurveda. But Ayurveda clearly defined some concepts of immunity such Asvyadhikshamatva, Oja, Bala, Vyadhibighatakarabhaba and Rasayana. In Covid-19, researcher found that such people are more vulnerable to disease and its severity. Such vulnerability depends upon person response to illness. Ayurveda may explain this vulnerability through its concepts of preventive, personalized and rejuvenation. The present review focused on cytokine storm and its understanding in perspective of ayurvedic concepts of immunity
Role of Taila Dhara Therepy in the Management of Various Types of Knee Joint Disorder
Authors: R Arse
Published: January 2024

Dhara is a part of Keraliya Panchkarma which means pouring liquid medium in a thin, continuous, stream over the body or affected area, when it is done all over the body it is known as Sarvanga Dhara. It comes under Parisheka Swedana. Dhara means pouring liquid medium in a thin, continuous, stream over the body or affected area. In this, fermented liquids are poured over the body in streams for a fixed duration of time as is done in any type of Dhara. It has been truly stated that Dhara is good for almost all diseases. The word Janu refers to knee and Dhara means to pour, mainly medicated oil. It is a very unique procedure mentioned as ‘Snehayukta Swedana’ due to the fact that it comprises both Snehana (therapeutic oleation) and Swedana (sudation therapy). The Taila (oil) used for this procedure does the Snehana and due to the Agni Samyoga in this procedure it has the resulting Swedana effect. Janu Dhara is advised in painful conditions caused mainly by Vata Dosha, usually for degenerative diseases, stiffness associated with bone, joint and or musculoskeletal pains, it relieves swelling and inflammation in the knee joint. At the end of the procedure perspiration is noticed and an increased range of motion can be observed. Previous clinical studies also suggest the efficacy of Janu Dhara in knee joint pain. Janu Dhara helps to tone muscles, provides lubrication and improves the working mobility of the joint.
Comprehensive Ayurvedic Management of Calcaneus Spur- A Single Case Study
Authors: M Bisht
Published: January 2024

Agnikarma is an important para-surgical procedures mentioned in Ayurveda. It has emerged as integral part of the Ayurvedic therapeutics. Agnikarma is a thermal and minimally invasive procedure that induces controlled, pointed and therapeutic burns over the regions that are tender or painful. Acharya Sushruta has advised Agnikarma for Snayugata Vata and Asthigata Vata. Painful heel due to prolonged standing is relatively common foot problem in modern era and predominant cause of such pain is calcaneal spur. The calcaneal spur is a condition of pointed bony outgrowth of heel bone. Usually, it affects people day to day routine life and once manifested it becomes difficult to cure. It is caused due to deposition of calcium on underside of heel bone over a prolonged period of time. It is diagnosed by the radio-logical examination (X-RAY). As far as modern medicine is concerned there is no safe and cost-effective treatment available of calcaneus spur. Pharmacological treatment used are NSAID’s, analgesic drugs, steroid injections, and exercises. The surgical treatment is release of plantar fascia and excision of calcaneus spur but complications are incomplete relief of pain and nerve damage. In Ayurveda Agnikarma is one of the competent treatments of calcaneus spur. Agnikarma is carried with special instrument called Pancha Dhatu Shalaka. This Shalaka is made up of five metals (Copper, Iron, Zinc, Silver and Gold). A patient successfully treated with Agnikarma therapy is presented in this case study
Dreadful Impact of Covid 19 and Disturbed Sleep Pattern of General Population and Health Care Workers Globally – A Review
Authors: Vd Singh Varnika
Published: January 2024

COVID-19 pandemic has greatly affected the mental health of people causing psychological distress with problems such as emotional disturbance, stress, mood alterations, anger, depression, irritability, confusion, emotional exhaustion, emotional isolation, insecurity, social stigma, post-traumatic stress symptoms, and especially insomnia reported in almost all sectors and strata of the society globally. Sleep is a recuperative and regulatory physiological need, affecting the systems biology and human immune system. COVID 19 is documented to disrupt sleep in various ways which may affect the immunity and the response of the individuals. The articles were searched on various search engines such as Pub med, Google scholar, science direct and the mesh terms such as Covid19, sleep, their different combinations and permutations was also explored and found that sleep which is known as one among the Trayoupstambha in Ayurveda severely affected during covid pandemic.
Approach in Health-Forming Technologies Based on the Balancing Sensory Stimulation/Deprivation from the Environment
Authors: AJ Baciu
Published: January 2024

The Medicine of the near future will develop not only along the path of improving diagnostics, treatment, rehabilitation, but also through the development of technologies for the formation (promotion) of health, human enhancement, and work productivity. It is clear that, due to their highly specialized multimodal sensory sensitivity, living systems are flexibly and plastically remodeling, changing structure and function in a completely physiological manner. Therefore, an attempt was made to conceptually and experimentally test the possibility of balancing sensory stimulation and sensory deprivation in their close dependence on the circadian sleep-wake cycle. A group of examined individuals practiced a mandatory evening walk in the park area for 40-60 minutes for 15 days and sensory deprivation by turning off artificial lighting, television, computer, gadgets and any other sensory signaling streams in the evening, starting from 8:00 pm and until going to bed (10:00 pm). The Facial Action Coding System (FACS) was applied to classify, qualitatively and quantitatively evaluate the facial psychomotor reactions of a person in the dynamics of his emotional state and by this tool indirectly reflects the balance of the activating and rewarding systems. The results obtained suggest that after a 15-day course of “Balancing Sensory Stimulation/Deprivation” the examined individuals maintain a positive emotional state during virtual immersion in a safe environment in the morning after a night's sleep compared to baseline measurements. It is strategically important to optimize labor, work, educational activities, prevent overload and fatigue, it is necessary to ensure the formation of a balance of circadian sensory stimulation and deprivation in combination with activities that improve the architecture and quality of sleep.
Gold Bhasma and Silver Parpam Used in Indian Traditional Medicines. Scientific Validation of their Interaction with Human Cells
Authors: S Badilescu
Published: January 2024

Bhasmas in Ayurveda and parpams in Siddha medicine are unique herbo-metallic/mineral preparations, effective remedies, fabricated from highly purified metals, treated with a variety of herbal decoctions and incinerated at high temperatures to, finally, obtain a metal ash, having a significantly reduced size and free of toxic effects. The processing techniques of bhasmas and their use as medicines have been described in ancient texts of Ayurveda such as Rasa Shastra, Charaka Samitha and Sushruta Sambita. It has been emphasized that, while Siddha medicine is close to Ayurveda, Siddha has been closely linked to the Tantric religious movement, traced back to the 6th century AD and it is believed that Alchemy played a more central role in Siddha medicine than in Ayurveda. Some of the most important bhasmas and parpams are briefly described; their fabrication and properties are mentioned. The study of the interaction of gold bhasma and silver parpam with human cells investigated by our group is described in the second part of this work. In this section, the cellular uptake and localization of the gold and silver particles in cancerous and normal cells have been elucidated by using, principally, the hyperspectral imaging method that combines the image with the spectral information.
Consequence of Use of Alcoholic Beverages in Modern Life-Style and Remedy with Yoga and Ayurveda
Authors: S Patnaik
Published: January 2024

Whenever we discuss regarding the alcoholism, which may be chronic or acute, it seems that the people who consumes alcohol may be due to any causes, it leads to a Alcoholic addiction. In the primary stage of alcoholic consumption, it may not harm to body but some socio-economic problem may occur. Sometimes the family members as well as friends also ignore to such activities of user knowingly or unknowingly. Users often take beetle with tobacco products in order to conceal the fact, which may also harm to their body. As the time passes and if it is not controlled by him-self or family, then such person falls down to an another world, from where he does not want to come back and he makes distances from family as well as good friends. At last a stage comes where he becomes ruined socially, economically, physically and mentally. Some users even try to commit suicide due to frustration. Homicidal activities and sexual violence may also be noticed. Now-a-days alcoholism is a commonest cause for incidents of murder and rape as well as traffic accidents. Hence if the consumer adopt the lifestyle described in Ayurveda and Yoga, then one can give up the addiction of alcohol and able to lead a happy and healthy life.
The Conservative Management of Erectile Dysfunction and Effectiveness of Physiotherapy Interventions; A Mini Review
Authors: Abubakar Ibrahim Ahmad
Published: January 2024

Erectile dysfunction is one of the most common male sexual disorders affecting 3% to 76.5% of men globally. Lack of active intervention in the recovery period of the affected penile muscles results in flaccidity, and prolonged flaccid state is known to cause irreversible damage to the cavernous tissue. Several relevant articles were searched in Google scholar, PubMed and Research gate, individual Physiotherapy/Conservative treatment approach were found and documented in this study. In this study we aimed at briefly reviewing and compiling relevant literatures on the effectiveness of Physiotherapy/ Conservative interventions on the management of erectile dysfunction. Different Physiotherapy/conservative management of erectile dysfunction was found to be promising and combination of different treatment methods will be more beneficial. Finally, it was concluded that Physiotherapy/conservative management of erectile dysfunction has been shown to be effective and should be considered as a first-line approach for men with erectile dysfunction
A Project to Set up a Day Care Center with Rehabilitation Services for the Betterment of Health of Senior Citizen
Authors: Haque Md Obaidul
Published: January 2024

Aloneness, carelessness and less reputation, sickness due to aged and in contradiction of lack of treatment are the most of the treacherous conditions which elderly are facing. Under the areas of the physical environment, the program, personnel, and inter-staff interactions, the development of a Day Care Center for senior citizens. The Center's mission is to offer seniors more thorough and efficient services. The program's social reinforcement, physical care, and mental components are focused on helping patients learn new skills and rediscover old ones so they may deal successfully with the challenges of aging and retirement. The day care center for the Senior citizens (elderly) can effectively cope with the continuous aging of the population, which is an important supporting form of community care service system. This project aims to Established a day care center for senior citizen for the betterment of their physical, social and mental health therefore, improve their quality of life with the help of qualified health professionals, quality infrastructure and active participation of service user.
Immunization: A Social Pact for Collective Health
Authors: Leal Daniela de Ulysséa
Published: January 2024

Vaccination is the most effective and economical way of preventing diseases and can be understood as a social pact for collective health
Advancing Quality in Health Economics and Dentistry: A Comprehensive Review
Authors: Lakshmi Billa Aishwarya
Published: January 2024

This review delves into the intersection of precision-driven healthcare and economic considerations within dentistry. Emphasizing meticulous care and resource allocation, it draws on seminal literature to present qualitative narratives of resilience and transformative experiences. Technology is highlighted as a promising catalyst, but challenges underscore the need for a universal lexicon in healthcare quality evaluation. Beyond scholarly discourse, the exposition becomes a chronicle of the human spirit, navigating the complex healthcare landscape. It encapsulates triumphs, reflecting not just metrics but the shared humanity in dental interventions and economic decisions. In the pursuit of quality, it portrays a scientific account marked by resilience, innovation, and commitment, shaping a healthcare environment where each individual's journey unfolds with enduring well-being and joyous smiles.
Unmasking Incivility in Nursing: The Hidden Cost to Patient Care
Authors: Lopez Michele Lucille
Published: January 2024

Nursing is a respected and noble profession. Nurses are considered compassionate, skillful, and highly ethical. Once again for the 21st consecutive year, nurses are ranked the most trusted profession. Despite the positive accolades that the nursing profession has received over the years, there is pervasive plague which diminishes the reputation of the profession; incivility. Incivility in the nursing profession is associated with decreased job satisfaction, staff shortages, and alterations in physical well-being and mental anguish. Nursing incivility has a negative impact on healthcare organizations. The results can be seen in decreased productivity, increased absenteeism, increased turnover, and overall job dissatisfaction. These can cause strains on other staff and healthcare administration. Besides issues with morale and employee satisfaction, there are real financial costs associated with lost productivity and employee turnover. Uncivil actions and behaviors among nurses are delivered in many different forms from subtle to very aggressive and overt. While the literature is abundant with evidence to substantiate the existence of incivility in the nursing profession, it is imperative to raise awareness to the current culture and climate in nursing as it poses great risk to patient safety. A hostile work environment fractures interpersonal relationships thus contributing to the breakdown of essential communication methods needed to maintain safe delivery of care. Attempting to deliver nursing care in an environment where there is intimidation, violence, and bullying increases the risk of nurses making errors such as with medication administration. Over 100,000 reports of medication errors a year are reported and the estimated cost of these errors is $42 billion annually. The repercussions associated with incivility are massive as the effects are felt on an individual, the profession, health care agencies, nursing academia, and consumer (the patient.
A Comparative In Vitro Study on Potential of Anti-Diabetic and Anti-Oxidant Properties in Extracts of Allium Hypsistum, Allium Przewalskanium and Allium Wallichii
Authors: A Singh
Published: January 2024

Allium hypsistum, Allium przewalskanium, and Allium wallichii are among the plants which are found at high altitude of Himalayan region. This in-vitro study has been focused on anti-diabetic and antioxidant properties of selected plants taken from Nepal region. Antidiabetic property was determined by in-vitro α- amylase inhibition method. Alcoholic extract of Allium hypsistum showed greatest α-amylase inhibitory action about 80% with an IC50 worth of 1.10 milligram/ ml followed by Allium przewalskanium which showed about 66% inhibition with an IC50 worth of 1.48 milligram/ ml. The antioxidant activities were evaluated using total phenolic content (TPC) and 2, 2-diphenyl -1-picrylhydrazyl (DPPH) radical scavenging assay method. Ethanolic extract of A. hypsistum showed the highest DPPH free radical scavenging property 67% as compared to reference ascorbic acid (75%). Among selected three plants, both TPC and %RSA revealing the antioxidant activities were found to be higher in A. hypsistum followed by A. prsewalskanium and A. wallichii.