bluuebunny/crossref_metadata_2025 huggingface dataset:
Геодезийн хэмжлийн нэгдмэл байдал нивелирийн рейкны хэвтээ компаратор
Authors: Д.Өнөрбилэг  , Б.Болормаа
Published: March 2023

СХЗГ-ын уртын эталоны лабораторид 3 м урт бүхий зурааст, бар код бүхий нивелирийн рейк ба 1 метрийн хяналтын ган ба латунь шугамыг шалгах зориулалттай хэвтээ компараторыг зохион бүтээлээ. Энэ компараторыг ашигланOIML R-35-1,2:2007 стандартын дагуу хамгийн дээд нарийвчлалын ангийн шаардлагад нийцэх, бүх төрлийн рейк, хяналтын латунь шугамын шалгалт тохируулгыг гүйцэтгэх ба барилга, зам гүүр, геодези, зураг зүйн ажилд уртын үндэсний эталоноос нэгж дамжуулах, хэмжлийн нэгдмэл байдлыг хангахад чухал үүрэг гүйцэтгэнэ. Хэвтээ компараторын систем нь 3 м урттай хос ган зам, гүйгч тэргэнцэр бүхий механик хэсэг ба лазер интерферометр, цацраг хуваагч, ретро ойлгогч толь бүхий оптик хэсгээс тогтоно. Механик хэсгийг маш тэгш гадаргуутай хүнд ширмэн плитаг төмөр ширээн дээр байрлуулсан. Хос рельс замын дагуу гүйх тэргэнцэр нь өсгөгч микроскоп, 2 ш микрометр толгой, гэрэлтүүлэг зэргээс тогтох ба түүн дээр ретро ойлгогчыг байрлуулсан. Гүйгч тэргэнцэрийн шилжилтийг, ретро ойлгогч болон лазер интерферометрын тусламжтай тодорхойлон, рейк болон хяналтын шугамын хэвийн уртын бодит уртыг тогтооно. Лазер интерферометрийн долгионы урт 632,9 нм (тогтворжилт нь 3,4 × 10-8) энэ нь уртын анхдагч эталон Ге-Не лазераас нэгж дамжуулсан. Нивелирийн рейк ба метрийн хяналтын шугамын шалгалт тохируулгын хэмжлийн өргөтгөсөн эргэлзээ 95%-ийн итгэх түвшинд 90 мкм орчимбайна. Шалгалт тохируулгын зарчим ба эргэлзээний төсвийн талаар дэлгэрэнгүй өгүүлнэ. Хэвтээ компараторын урт хугацааны тогтворжилт, олон удаагийн туршилтын үр дүнгүүд OIML R-35:2007 стандартаар тавигдах шаардлагад нийцэж байна.
The process model of creating cartographic products for solving the task of a cartographic production system synthesis
Authors: Chernov I.V. , Yakunin V.I.
Published: March 2023

The article deals with solving the tasks of designing a cartographic support system and arranging the process of its targeted application. The definition of its concept is given. Within the framework of the paper, electronic maps of the area are considered as products. The system functioning for the consumer is described. During the research, the results’ quality indicators vector of the production and publishing processes are substantiated. The functional-stochastic dependencies between the components of the results’ quality indicators vector are established and the operational functionality linking the performance indicator with the cost of resources and time is justified. A mathematical model of the purposeful production process of cartographic products is constructed, which enables predicting the degree of the goal achievement, a priori assessing its quality and synthesizing a system of cartographic production by means of a directional enumeration of the model parameters values. The simulation results let us formulate proposals on the structure of the cartographic support system based on the requirements imposed by the results. An illustrative numerical example demonstrating the operability of the offered method is given.
The Use of 5-Alpha Reductase Inhibitors Improves the Detection of Prostate Cancer by Increasing Opportunities for Repeated Prostate-Specific Antigen Testing: A Decade-Long (2007–2016) Nationwide Observational Study in Korea
Authors: Ko Young Hwii , Kim Sang Won , Kim Hoseob , Bae Yoon-Jong
Published: March 2023

Purpose: The aim of this study was to investigate the influence of taking 5-alpha reductase inhibitors (5ARIs) on the detection of prostate cancer (PCa), considering the reported low uptake of prostate-specific antigen (PSA) testing among Korean men.Materials and Methods: From Korean National Health Insurance Sharing Service data, the number of men older than 40 years who were prescribed 5ARIs from 2007 through 2016 was identified. The association of 5ARI prescriptions with newly registered PCa was analyzed.Results: In total, 1,528,128 men who took 5ARIs for a mean of 1.523±2.221 years were identified. Among 138,614 patients with PCa, 68,529 (49.4%) took 5ARIs and 70,085 did not. The incidence of PCa was significantly higher in the 5ARI group than in the non-5ARI group during all study years (p<0.001) except for 2007. Adjusted for age, the non-5ARI group had a significantly lower likelihood of PCa detection (hazard ratio [HR], 0.854; p<0.001) and radical prostatectomy, including robot-assisted procedures (HR, 0.834, p<0.001). The mean number of PSA tests was about 2 times higher in the 5ARI group than in the non-5ARI group (3.98 vs. 2.18, p<0.001). Among the subjects who took 5ARIs, the incidence of PCa increased up to 3 years of administration, followed by a decreasing trend thereafter (p<0.001).Conclusions: From this observational study in a country with limited PSA testing uptake, the prescription of 5ARIs, for which repeated PSA testing is encouraged to select suitable patients, enhances the detection of PCa, but does not prevent its development.
Bladder Cancer in South Korea: Analysis of Trends and Risk Factors of Bladder Cancer in South Korea Using a Nationwide Database
Authors: Yoo Sangjun , Han Kyung-Do , Kim Kwang Taek , Choi Woo Suk , Ha Yun-Sok , Kim Jeong Hyun , Kwak Cheol
Published: March 2023

Purpose: The purpose of this study was to evaluate the incidence rate and trend of bladder cancer in South Korea using a nationwide database. In addition, we aimed to determine the risk factors and their influence on the incidence of bladder cancer.Materials and Methods: We extracted data from the health insurance database and estimated the incidence rate of newly developed bladder cancer from 2007 to 2019. In addition, we conducted further analysis of 10,210,654 individuals who underwent general health check-ups in 2009 to investigate the risk factors for bladder cancer. Variables associated with bladder cancer were evaluated using Cox regression analysis.Results: Bladder cancer significantly increased especially in the last 10 years. In 2019, 21.07 people per 100,000 were diagnosed with bladder cancer, whereas 13.62 people per 100,000 were diagnosed with bladder cancer in 2007. The compound annual increase rate from 2007 to 2019 was 3.7%. Among 10,210,654 individuals who had general health check-ups in 2009, bladder cancer was diagnosed in 83 people per 100,000 population in the 10-year follow-up. After adjusting for other variables, smoking-related variables were most significantly associated with bladder cancer incidence, followed by metabolic syndrome and its related variables. In the further analysis of the effect of smoking on bladder cancer according to sex, the smoking amount was more significantly associated with bladder cancer incidence in women compared to that in men.Conclusions: The crude incidence of bladder cancer continuously increased in South Korea during the last 10 years. Smoking, in addition to sex, age, and metabolic syndrome-related variables, was significantly associated with bladder cancer, especially in women.
Current Update on Prostate Cancer Immunotherapy
Authors: Kim Juliana E. , Lee Kunwoo , Kim Isaac Yi
Published: March 2023

Immunotherapy encompasses a wide array of treatment modalities that utilize our natural defense system to fight against cancer and in recent years has contributed to significant improvement in survival and quality of life in patients. However, its use in prostate cancer has been limited due to low efficacy and lack of effective biomarkers. Prostate cancer’s unfavorable tumor microenvironment characterized by T-cell exclusion and expansion of T-reg cells, along with the possible inhibitory effect of androgen deprivation therapy (ADT) on the immune system further explains this poor response to immunotherapy. Here, we review current immunotherapies and ongoing clinical trials as well as potential biomarkers being investigated to predict treatment responses to immunotherapy. Finally, we discuss the conflicting results on the best approach to sequencing immunotherapy in relation to ADT.
Dyspnoea, haemoptysis and fever progressing to acute respiratory failure. A didactic story with a happy ending.
Authors: Dolezalova Karolina , M. Fajt , L. Leová , P. Heinige
Published: March 2023

A dynamic case report in which the authors present a multidisciplinary
collaboration in a dyspnoic adolescent girl who coughs up blood, has a
high temperature and rapidly progresses to respiratory failure.
Laboratory findings, imaging results, and their interpretation are
shown. Current recommended management is discussed.
Complete mitochondrial genomes of two moths in the tribe Trichaeini (Lepidoptera: Crambidae) and their phylogenetic implications
Authors: Tang Ci , Du Xicui
Published: March 2023

The complete mitochondrial genomes of two Prophantis species in the
tribe Trichaeini (Lepidoptera: Crambidae) were sequenced using
high-throughput sequencing technology. They were assembled and
annotated: the complete mitogenomes of P. octoguttalis and P. adusta
were 15,197 bp and 15,714 bp, respectively, and contain 13
protein-coding genes, 22 transfer RNA genes, two ribosomal RNA genes,
and an A + T-rich region. Their arrangement was consistent with the
first sequenced mitogenome of Lepidoptera, from Bombyx mori
(Bombycidae). The nucleotide composition was obviously AT-biased, and
all protein-coding genes, except for the cox1 gene (CGA), used ATN as
the start codon. Except for trnS1, which lacked the DHU arm, all tRNA
genes could fold into the clover-leaf structure. Phylogenetic trees of
Crambidae were reconstructed based on mitogenomic data using Maximum
likelihood (ML) and Bayesian inference (BI) analysis methods. Results
showed that Trichaeini in this study robustly constitute a monophyletic
group in Spilomelinae, with the relationships (Trichaeini + Nomophilini)
+ ((Spilomelini + (Hymeniini + Agroterini)) + Margaroniini). However,
the affinities of the six subfamilies Acentropinae, Crambinae,
Glaphyriinae, Odontiinae, Schoenobiinae and Scopariinae within the
“non-PS Clade” in Crambidae remained doubtful with unstable topologies
or low supports.
Changes in the Natural Water Retention of mountainous landscapes since the 1820s in the Austrian Alps
Authors: Gabriel Stecher , Hohensinner Severin , Herrnegger Mathew
Published: March 2023

Interactions of humans with the environment are strongly related to land
use and land cover changes and the available ecosystem services. In last
decades, these changes have led to a degradation of ecosystem services,
including water regulation and flood control. In Alpine areas of
Austria, land cover changes have increased flood risk since the mid of
the 19 century. In this paper, we assess the
influence of these long-term land use changes on the landscape’s ability
to retain water using the qualitative Water Retention Index (WRI). The
changes are thereby evaluated using the historical (1826-1859) and
present (2016) land cover situation, which is to our knowledge the first
high-resolution and regional application of the WRI. The results show
that the water retention potential mimics the mountainous characteristic
and features. Except for areas strongly dominated by settlement areas,
the highest retention potentials are found in valley floors and the
lowest values are depicted along the Alpine main complex. In low-lying
areas, the retention decreased by over 10 %. It was found that this
decrease can be mostly attributed to settlement expansion. Above 1250 m
land use transformations led to slightly increasing water retention
values owing to the transformation of wasteland or glaciers to stagnant
waters and to the expansion of forest and grassland in high elevations.
This examination allows for a holistic and spatially distributed LULCC
impact assessment on the landscape’s water regulation capacities and
offers valuable high-resolution information for future land use planning
and sustainable land development.
The application of solid-state fermentation using mushrooms for the production of animal feed
Authors: Cason E.D , Rothmann C. , Rothmann L.A , Viljoen B.C
Published: March 2023

The increasing growth of agro-industrial activity resulting in excessive
amounts of agri-waste has led to the accumulation of a large quantity of
lignocellulosic residues all over the world, in particular,
deforestation initiatives for the removal of invasive trees in South
Africa. These lignocellulosic residues are rich in energy resources
consisting of a mixture of natural polymers based on lignin, cellulose
and hemicellulose. The use of lignolytic fungi such as mushrooms in
solid-state fermentation could sufficiently degrade the indigestible
lignocellulosic components and add medicinal and nutritional value to
otherwise unusable, high-energy waste material. The digestive type of
animal for which the potential feed is developed must be identified and
considered before deciding on the bioconversion method and process,
since the outcomes for obtaining potentially high-quality feeds for
non-ruminant and ruminant animals are different. The current study
presents the data of the bioconversion of lignocellulosic substrate
using solid-state fermentation with the edible and medicinal mushrooms,
Ganoderma lucidum, Pleurotusostreatus, and a possible new
species, to increase digestibility and nutritional value to be applied
as ruminant animal feed. The solid-state fermentation process was
optimised and the resulting product analysed for the degradation of the
lignocellulosic components. Results indicated that the solid-state
fermentation duration and mushroom species were key components in
achieving significant degradation. Data obtained after 18 weeks of
degradation indicated a significant (p < 0.05) reduction in
the acid detergent fibre, acid detergent lignin and neutral detergent
fibre fractions of the biomass, with up to 20% reduction in
indigestible components. This increase in digestibility could contribute
to to increased energy availability for ruminant animals.
Neuromorphic Artificial Vision Systems Based on Reconfigurable Ion-modulated Memtransistors
Authors: University) zhen yang (Peking , University) Teng zhang (Peking , University) Keqin Liu (Peking , University) Bingjie Dang (Peking , University) Liying Xu (Peking , University) Yuchao Yang (Peking , University) Ru Huang (Peking
Published: March 2023

Conventional vision systems suffer from lots of data handling between
memory and processing units. Inspired by how humans recognize noisy
images and the flexible modulation on the timescale of ion dynamics
inside an emerging memtransistor, we report a novel neuromorphic vision
system based on the ion-modulated memtransistors. By controlling the ion
doping processes under adequate stimuli strengths, both short-term and
long-term ion dynamics can be utilized to deliver energy-efficient data
processing. When dealing with image reconstructions, the short-term
accumulation effect of the device can help filter noises in a set of
received noisy images while enhancing the original pattern information.
The increased contrast can help distinguish the actual contents. To
demonstrate systematic performances with the reconfiguration of devices,
we extract the nonlinear relationship between channel conductance
variation and the amplitude of gate pulses into the network-level
simulation. Also, with the nonvolatile conductance change
characteristic, the task of recognizing noisy images is performed to
verify the versatility of ion-modulated memtransistors in the
neuromorphic artificial vision systems.
Fast anomalous traffic detection system for secure vehicular communications
Authors: Al-Haija Qasem Abu , Alsulami Abdulaziz A.
Published: March 2023

Nowadays, vehicle industrialization has realized several connectivity
protocols to enable in-vehicle network communication. These protocols
have been collectively standardized in a de facto standard for the
in-vehicle network viz controller area network (CAN). Merely, CAN
protocol shortages several security features that make vehicular
communications susceptible to diverse message injection attacks that may
mislead original electronic control units (ECUs) or cause failures.
Therefore, defending the in-vehicle network from cyber-attacks is an
essential concern. This paper proposes a fast anomalous traffic
detection system for secure vehicular communications. The proposed
system differentiates the performance of four different machine-learning
approaches: Adaboost trees (ABT), Coarse decision trees (CDT), naïve
Bayes classifier (NBC), and support vector machine (SVM). The models
were evaluated on a recent dataset from a real-time vehicular
communications environment, the car-hacking-2018 dataset. Specifically,
the system considers five balanced classes, including one normal traffic
class and four classes for message injection attacks over the in-vehicle
controller area network: fuzzy attack, DoS attack, RPM attack
(spoofing), and gear attack (spoofing). Our best performance outcomes
belong to the ABT model, which notched 99.8% classification accuracy
and 6.67 µseconds of classification overhead. Such results have
outweighed existing in-vehicle intrusion detection systems employing the
same/similar dataset.
Nanoemulsion Myricetin preparation increases the anticancer efficacy against Triple-negative Breast Cancer cells
Authors: SHARMA PREETI , CHATURVEDI SHUBHRA , KHAN MOHD , RAI YOGESH , Bhatt Anant , Najmi Abul , Akhtar Mohd , Mishra Anil
Published: March 2023

Background and purpose: Myricetin
(3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)chromen-4-one) is a
polyhydroxyfavonol compound widely found in nature has been shown to
possess anticancer effects in various cancers. Despite its efficacy,
poor water solubility and low oral bioavailability hinders its
therapeutic application. To overcome these limitations, Nanoemulsion
(NE) emerged as a promising approach that combines the advantages of NE
into a single delivery system. The present study aimed to investigate
the advantage of myricetin loaded NE over and above native Myricetin.
Experimental Approach: The nano-emulsion was formulated using Capryol 90
as oil, Tween 20 as a surfactant, and Transcutol HP as a co-surfactant.
Further comparative analysis of Myricetin and nano-emulsified Myricetin
(Myr-NE) were carried out in triple negative breast cancer (MDA-MB-231)
cells for anticancer activity. Key results: The optimized Myr-NE had a
zeta potential of -6.35±0.3, an average particle size of 89.32±2.8 nm,
PDI of 0.105±0.02, and a spherical shape as confirmed in transmission
electron microscopy. Diffusion-dominant drug release was observed with
95.49±2.84 % Drug release for 24hrs, 2-fold higher than Myr-suspension.
When nano-emulsified, Myricetin exhibited efficient inhibition of cell
proliferation, clonogenicity, and increased apoptosis with IC50 of 37
µM, a dose ~2.5 fold lower than native Myricetin.
Mechanistic insights reveal that Myr-NE induced more ROS generation and
considerably inhibited AKT and mTOR activation, leading to enhanced
anticancer activity. Conclusions & Implications: In conclusion, these
findings suggest that the therapeutic efficacy of Myricetin
significantly improved through a novel Myr-NE formulation which may be a
promising therapeutic approach for treating TNBC.
T1, T2 and T2* relaxations in MRI based on Gd5Si4 nanoparticles of varying sizes
Authors: Hunagund S , Rosenberg J , Harstad S M , Gupta S , Pecharsky V , El-Gendy A A , Hadimani R L
Published: March 2023

Our previous study has shown that ferromagnetic gadolinium silicide
(Gd5Si4) nanoparticles (NP) could be potentially efficient T2 CA for MRI
with significantly reduced echo time (TE) compared to Superparamagnetic
Iron Oxide Nanoparticles (SPION) [1]. T2 CA are defined by their
relaxivity, r2, which is dependent on both the saturation magnetization
(Ms) and size of the NPs [1,2,4]. In this study, effect of Gd5Si4
NPs of varying sizes and concentrations are investigated on T1, T2 and
T2* (effective/observed T2) relaxations times. Gd5Si4 NPs categorized
into three fractions (named S1, S2 and S3) based on average sizes of 586
nm, 287 nm and 135 nm respectively as analyzed from SEM images (Fig. 1).
XRD analysis on the combined samples shows that Gd5Si4 is the major
phase while GdSi and Gd5Si3 are present as the minor phases in all
fractions (Fig. 1). Magnetic properties measured in VSM reveal that the
Curie temperature (Tc) decreases for Gd5Si4 phase from 312 K for S1 to
304 K for S2 and is undetectable in S3. The M-H curves at 300 K exhibits
ferromagnetic behavior descending to paramagnetic as we move from S1 to
S3 fraction (Fig. 1). MR data were acquired on the 21.1 T (900 MHz)
magnet. The results shown in Table 1 indicate that higher concentrations
of NPs shorten the T2 and T2* relaxation times and the contrast
disappears rapidly at higher dilutions. The S2 fraction at 1/20 dilution
shows notably shortened T1 and T2 relaxation times compared to the other
two fractions. Although S1 has higher Gd5Si4 phase volume fraction and
larger average particle size compared to S2, further investigation is
needed inorder to establish the reason for shortened relaxation times
compared to the S1 fraction.

Acknowledgements Work at the Ames Lab was supported by DOE
(contract No. DE-AC02-07CH11358). Work at VCU was partially funded by
NSF, Award No.: 1610967. Work performed at the NHMFL is supported by the
State of Florida and the NSF (agreement No. DMR-1157490).

This paper was presented at the ICM 2018, San Francisco.
Nephrotoxicity of low-osmolar and iso-osmolar iodinated contrast media -- a pharmacovigilance study based on real-world database
Authors: hewei zhang , Li Yue , Ye Xiaofei , Guo Xiaojing
Published: March 2023

Abstract Aim: We aim to compare nephrotoxic spectrum of IOCM and that of
LOCM in a more intensive and comprehensive perspective using the
real-world database. Methos: This is an observational, retrospective,
pharmacovigilance study based on Vigibase. 7 products (iodixanol,
iohexol, iopamidol, iopromide, iobitridol, ioversol and iomeprol) of ICM
were included. Variable matching method was used for deduplication
procedure. Two data mining method, reporting odds ratio (ROR) and
bayesian confidence propagation neural networks of information
components (IC) were used to detect signals for the full database,
gender stratums (male and female), age stratum (0 to 64 years, 65 to 74
years and 75 or more years) and pooled analysis of total renal adverse
events (AEs). Package ‘base’, ‘utils’ and ‘pheatmap’ of R language
(version 4.1.2) were used to perform analysis and plot figures. Results:
We got 2703 ICSRs and 3155 renal AE reports. The five most frequently
reported were acute kidney injury, renal failure, renal impairment
azotaemia and anuria. All ICM had highest signal value detected in age
≥75 years. Iodaxinal and iohexol had most signals detected. In pooled
analysis of renal AEs, no signals detected for iopamidol, iomeprol and
iopromide in the full database stratum. Conclusion: No evidence approved
IOCM has safer nephrotoxicity than LOCM. CIN spectrum varies a lot
within LOCM. Regarding to the whole population, not all products of ICM,
such as iopamidol, iomeprol and iopromide, is likely to cause CIN.
Skilled performers show right parietal lateralization during anticipation of beach volleyball attacks
Authors: DeCouto Brady , Smeeton Nicholas , Williams Andrew
Published: March 2023

The way in which biological motion is processed, globally or locally,
may depend upon the observer’s perceptual skill or experience with the
stimulus. Skilled athletes with extensive perceptual experience
observing sport-specific movements use globally distributed motion
information across an opponent’s body to anticipate actions, while less
skilled athletes focus on single-reliable kinematic cues. Published
reports have demonstrated that attention can be primed globally or
locally before perceptual tasks, and such an intervention could
highlight motion processing mechanisms used by skilled and less skilled
observers. In this study, we investigate skill-differences in biological
motion processing using attentional priming. Skilled (N = 16) and less
skilled (N = 16) players anticipated temporally occluded videos of beach
volleyball attacks while being primed using a Navon matching task. EEG
at parietal regions was measured to index global or local attention.
Skilled players were more accurate than less skilled players across
occlusion intervals and priming conditions. Global priming resulted in
better performance for both skill groups. Skilled players showed
significantly reduced alpha and beta power in the right compared to left
parietal region, but brain activity was not affected by priming
interventions. Our findings highlight the importance of right parietal
dominance for skilled performers, which may be functional for inhibiting
left hemispheric local processing or enhancing visual spatial attention
for dynamic visual scenes. Further work is needed to systematically
determine the function of this pattern of brain activity during skilled
anticipation in other contexts.
Why and when do freshwater fish migrate? Observations of migration patterns of the native fishes from the Iberian Peninsula (SW Europe)
Authors: Ordeix Marc , Casals Frederic
Published: March 2023

We reviewed information on Iberian freshwater fish to characterize their migratory status and identify migration reasons and periods. Most species migrate (87.3 %; 62 species from 15 families). A large number are potamodromous species (45 species from 6 families) but diadromous species (17 species from 11 families) also exist, including anadromous (9 species) and cata¬dromous (8 species). The spawning period is a primary driver of fish migration but feeding and refuge-associated migrations also take place. Sexual maturity is the most important cue triggering fish migration, and other important factors include water temperature, river flow, currents, salinity and photoperiod. Spawning and migrating periods are in general prolonged and vary among years, as a response to the environmental variability of Mediterranean river systems, which are the most frequent in the Iberian Peninsula. Migratory movements of the various native species of each site cover almost the whole or the whole year. Therefore, to allow fish migration, Iberian freshwaters should always be connected, or their fish passes should be permanently, or practically always, in operation.
Probability of allogeneic hematopoietic stem cell transplant failure depending on the recipient's killer immunoglobulin-like receptor genotype
Authors: Maslikova U. V. , Khamaganova E. G. , Drokov M. Yu. , Urybin I. Yu. , Mikhaltsova E. D. , Kuzmina L. A. , Parovichnikova E. N.
Published: March 2023

Introduction. Natural killers are the "first line" of antitumor and antiviral protection in the early stages after аllogeneic hematopoietic stem cell transplantation. Quantitative characteristics reach normal values already in the first month after the infusion of blood stem cells to the recipient. Self-tolerance of natural killers is achieved due to many receptors on their surface, but killer immunoglobulin-like receptors play a key role. Their role is to recognize "self" cells and block signals aimed at destroying their own cells. Knowledge of the functional activity of natural killers urged to studying the impact of mismatches between the inhibitory receptor gene and the ligand on the development of allogeneic hematopoietic stem cell transplant failure.The aim of research was to study the probability of the graft failure development in allogeneic hematopoietic stem cell transplantation depending on the recipient's killer immunoglobulin-like receptor genotype.Material and methods. Genotyping of killer-cell immunoglobulin-like receptors in 66 recipients of blood stem cells by the polymerase chain reaction method was performed in the study. Using an online calculator, receptors were classified as "best", "better" and "neutral" depending on the genotype. The end point of the assessment was the development of graft failure in the presence of different genotypes of immunoglobulin-like receptors in the recipient.Results. According to the data obtained, the presence of the “best” and "better" killer-cell immunoglobulin-like receptor genotype in the recipient significantly increased the risks of developing various forms of graft failure.Conclusion. The presence of the KIR2DL3 genotype in a recipient of hematopoietic stem cells significantly (by 3 times) reduces the likelihood of primary graft failure. This result is of great prognostic significance, although at present no ways of influencing it have been developed. The presence of the “best” killer immunoglobulin-like receptors genotype in the recipient increases the likelihood of developing graft failure by more than 3 times compared to the best and neutral genotype (44.4% vs. 13.4%).
Nephrolithiasis in related kidney donors
Authors: Perlin D. V. , Dymkov I. N. , Terentyev A. V. , Perlina A. D. , Alexandrov I. V.
Published: March 2023

Introduction. Long-term results of renal transplantation from living donors are much better than the results of cadaveric transplantations. Recently, because of the shortage of living donors, some centers have started using kidneys from living donors with asymptomatic stones as a potential solution for the problem. However, the optimal surgical solution for such situations has not yet been developed.Aim. To evaluate our obtained transplantation results of using the kidneys from living donors with nephrolithiasis and compare them with the literature data.Material and methods. In the period from 2012-2021, renal transplantations in our clinic were done in three patients from related donors with stones in the kidney. One donor underwent mini-percutaneous lithotripsy one month prior to nephrectomy. The other two underwent simultaneous retrograde lithotripsy and laparoscopic donor nephrectomy. In these cases a holmium or thulium laser was used for the destruction of calculi. All donors underwent laparoscopic retroperitoneal nephrectomy.Results. All stones were successfully removed. There were no surgical complications in donors during and after procedures. Warm ischemia time did not exceed 3.5 minutes. The general length of hospital stay was 10 days in case of predonation stone removal surgery and 6 and 4 days in the cases of simultaneous procedures, respectively. All grafts were transplanted to related recipients. One of the recipients was treated with hemodialysis before transplantation, the other one with peritoneal dialysis. The third recipient underwent preemptive transplantation (before the start of dialysis). The graft function in all cases was immediate. During the follow-up period (9-57 months), no signs of nephrolithiasis were seen in either donors, or recipients.Conclusions. Consideration of potential donors with stones in one kidney might increase the number of living donor renal transplantation. Simultaneous RIRS and laparoscopic donor nephrectomy can be considered as an alternative to sequential operations or ex vivo stone extraction. The presented technique is reproducible, safe and was not associated with an increased length of hospital stay.
Easy to say, hard to do. To the anniversary of two fundamental discoveries. Part 3
Authors: Anisimov A. Yu.
Published: March 2023

On the eve of the anniversaries of two historical events: the 145th anniversary of the experiments in which Eck's fistula was performed and the 55th anniversary of the successful clinical approbation of the selective distal splenorenal anastomosis, a retrospective analysis of the key historical stages in the development of portal hypertension surgery was performed: from the first attempts to describe the anatomy of the hepatic vascular system, explaining its purpose in the body, the development of direct portacaval anastomosis, and the widespread use of selective splenorenal anastomoses, to the Transjugular Intrahepatic Portosystemic Shunt procedure and orthotopic liver transplantation. Meantime, the emphasis has been focused on the most colorful characters of researchers and clinicians who passed this path. The expediency of an integrated approach in solving the problems of portal hypertension with the development of both fundamental and applied clinical and organizational aspects has been substantiated. It is shown that the discoveries born from summarizing the results achieved by numerous researchers have contributed to a better understanding of this field of medicine, have become a solid foundation for what we have today and are a reliable platform for a successful start into the future.
Refrigerator Performance With Natural Refrigerant (R1270) Double Pipe Heat Exchanger, Various Capillary Pipe Lengths
Authors: Sumardi Kamin
Published: March 2023

Refrigerator technology continues to develop towards a better and more efficient direction. Refrigerator must be given a touch of innovation to get the best performance. This study aims to obtain data on the performance of refrigerators with double pipe heat exchanger innovation and variations in the length of the capillary tube. The research method used is experimental. The experiment was carried out on a 1/6 PK refrigerator trainer, the ratio of the size of the double pipe heat exchanger was 1/4:1/2, and the variations in the length of the capillary pipe were 1.5m, 2m, 2.5m, and 2.75m. The diameter of the capillary tube is maintained at 0.028 inches. The initial refrigerant used is refrigerant R-134a, which is then retrofitted by the drop in substitute method by refrigerant R-1270 as the refrigerant being tested. The load used is 1.5L mineral water. The results showed that the use of 1.5 m capillary pipe and double pipe heat exchanger was able to increase the value of the refrigeration effect up to 49%, the value of work efficiency (CoP) increased by 22% compared to the refrigerator system using R-134a. Electric power consumption has decreased by up to 25%, thereby reducing the cost of electricity bills. This study has shown that the use of refrigerant R-1270 in a refrigerator with a double pipe heat exchanger and a long capillary tube with a diameter of 0.028 inches improves performance and saves electricity consumption.
Identification of Fungus Causing Onychomycosis in Chicken Meat Traders in Traditional Markets
Authors: Mayumi Ni Kadek Sintya , Habibah Nur , Suyasa I Nyoman Gede
Published: March 2023

Onychomycosis is an infection of the nails caused by dermatophyte, non-dermatophyte, and yeast. Infection is characterized by discoloration of the nails and thickening of the nail plate. The proliferation of fungi can occur in jobs that are often in direct contact with dirty, damp and wet work sites such as chicken meat traders. Because chicken traders make direct contact with chicken meat which causes the hands and nails of traders to become wet and moist. The purpose of this study was to identify the pathogenic fungi that cause onychomycosis on the fingernails of chicken meat traders at traditional market in Batubulan Village. Identification was carried out by the culture on Saboraoud Dextrose Agar (SDA) media and followed by microscopic examination of the growing fungal colonies with Lactophenol Cotton Blue staining. The results of this examination were that all samples were grown on Saboraud Dextrose Agar (SDA) media. The dermatophyte group was identified as many as 17 and the Yeast group was identified as many as 14. Most of the fungi identified on the fingernails of chicken butchers were non-dermatophytes, 22 of which were Aspergillus sp.
The GARCH-X(1,1) Model with Exponentially Transformed Exogenous Variables
Authors: Nugroho Didit , Dimitrio Obed , Tita Faldy
Published: March 2023

This study applies the exponential transformation to the exogenous variables in the GARCH-X(1,1) model. The model assumes that the returns error is Normally and Student-t distributed. The data type used as an exogenous variable in the GARCH-X(1,1) model is Realized Volatility 10 minutes. Empirical analysis was carried out based on stock price index data FTSE100 and SP500 daily period from January 2000 to December 2021. Metropolis Adaptive Random Walk method was implemented in the Markov Chain Monte Carlo algorithm to estimate the model parameters. The High Posterior Density interval at the 95% level indicates the significance of the exponential transformation for the exogenous variable in both cases assuming a distribution for the returns error. Moreover, the Akaike Information Criterion (AIC) value indicates that the proposed model outperforms the basic GARCH-X(1,1) model, where the best fit model is given by the Student-t distributed model.
Self-Spiritual Healing Therapy on Anxiety Conditions in Diabetes Type II in the Lovina Tourism Area
Authors: Made Kurnia Widiastuti Giri
Published: March 2023

After pandemic, post-acute care is being important to maintain wellness in patient with chronic disease. Diabetes type II (diabetes mellitus) is a degenerative chronic disease whose number of cases is increasing from time to time. This increase is also in line with the increasing interest of individuals in spiritual healing and this spiritual healing method is efficient because it can be done independently and with online tutorials. This study aims to prove the effectiveness of spiritual healing in reducing anxiety levels in diabetes type II patients. This research is Quasi-experimental research (quasi-experimental). A quasi-experiment is an experiment that requires treatment but does not use random assignment in creating comparisons to conclude that there is a change due to treatment. This research in the first year uses quantitative and descriptive qualitative analysis techniques according to the characteristics of the data needed to describe each research problem. Based on the results of data analysis and discussion, it was concluded that anxiety is a condition where our bodies experience feelings of anxiety and restlessness that can arise from the presence of a trigger (stressor). The role of yoga in reducing anxiety in most journals is said to be positively related and proven to have a significant effect.
Two sides of the same mirror: the point of view of implementers and recipients of public reception and integration policies, on the access to basic and public resources during COVID-19 pandemic of asylum seekers and refugees
Authors: Leão Varela Ana , Rodrigues Teresa
Published: March 2023

We argue that crisis triggered by COVID-19 increased pre-existing vulnerabilities in what concerns to minorities’ access to basic and public social resources in receiving countries, taking the Portuguese reality as an example. Our conclusions are based on the investigation made under the scope of the PPEACE project (Public Policies and Reception of Foreign Citizens Project), which aims to contribute to scientific advance in public policies and to propose better-informed policy options for the reception of asylum seekers and refugees. Based on the results of 180 questionnaires applied from October 2020 to February 2021, to asylum seekers and refugees, public entities, and NGO representatives we confront migrants’ perceptions/experiences and service providers’ needs and views. Through their eyes we try to discuss the impact that the pandemic had on public policies for reception and integration, the obstacles upraised to guaranteeing the access of this vulnerable individuals to public resources, satisfaction of basic needs, and the most affected dimensions of their daily life. The results of our empirical study reveal that the perceptions of recipients and implementers of public policies in times of pandemic are two sides of the same mirror and differ considerably. Differences are substantial between receivers and givers but with no significant or fracturing discrepancies. In this sense, this methodologic exercise reinforces the importance of participatory processes for better understanding the impacts of public policies on vulnerable groups, on the access to fundamental rights and satisfaction of basic needs.
PENGARUH AMONIASI DENGAN LEVEL UREA YANG BERBEDA PADA KULIT SINGKONG TERHADAP KADAR AIR, ABU, PROTEIN KASAR DAN SERAT KASAR
Authors: Setiawati Rona , Fathul Farida , Erwanto Erwanto , Sutrisna Rudy
Published: March 2023

Penelitian ini bertujuan untuk mengetahui pengaruh amoniasi dengan level urea yang berbeda pada  kulit singkong terhadap kadar air, abu, protein kasar dan serat kasar.

Penelitian ini dilaksanakan pada April–Juni 2021 bertempat di Laboratorium Nutrisi dan Makanan Ternak, Jurusan Peternakan, Fakultas Pertanian, Universitas Lampung. Parameter yang diukur adalah kadar air, abu, protein kasar, dan serat kasar. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) dengan 4 perlakuan dan 5 ulangan. Perlakuan yang diberikan yaitu limbah kulit singkong tanpa urea (P0), limbah kulit singkong dengan 1,5% urea (P1), limbah kulit singkong dengan 3% urea (P2), limbah kulit singkong dengan 4,5% urea (P3). Data yang diperoleh dianalisis statatistik dengan menggunakan Analysis Of Variance (ANOVA) dengan uji lanjut polynomial orthogonal. Hasil penelitian menunjukkan bahwa pengaruh amoniasi dengan level urea yang berbeda berpengaruh nyata (P<0,05) terhadap kadar air, abu, protein kasar dan serat kasar.
Data to the spider fauna (Araneae) of Lake Velence
Authors: Kancsal Béla , Szinetár Csaba , Bognár Vivienn , Angyal Dorottya
Published: March 2023

153 spider species were collected in the reedbed of Lake Velence. This is the first faunistical survey about the area.
A Dél-Mezőföld Orthoptera együtteseinek összehasonlító elemzése
Authors: Krausz Krisztina , Pápai János
Published: March 2023

In the Southern-Mezőföld the different sized and mosaic-like patches of various surfaces of sandy and loess grasslands, marshes and marshy fields are an lesser-known area for entomologist. There are rich Orthoptera fauna: 45 species were detected between 2005 and 2008. The Orthoptera assemblages of the marshy fields and sandy grasslands were separated in the CoA scattergram. Tree diagram of the Orthoptera species made by cluster analysis shows four correlated groups on the basis of their occurrence rates. Correlation between the degradation and homogeneity of the habitats and the number and density of the Orthoptera species were also observed.
The water beetles (Coleoptera: Hydradephaga, Hydrophiloidea) of the Nagy-berek area, Lake Balaton, Hungary
Authors: Lőkkös Andor
Published: March 2023

During a faunistical exploration of Nagy-berek at the Lake Balaton (Hungary) carried out between 2003 and 2009, 136 water beetle species were recorded. Important faunistic records are new localities of Hydroporus longicornis Sharp, 1871, H. melanarius Sturm, 1835, H. neglectus Schaum, 1845, H. notatus Sturm, 1835, H. umbrosus (Gyllenhal, 1808), Laccornis kocae (Ganglbauer, 1904), Agabus nebulosus (Forster, 1771), A. striolatus (Gyllenhal, 1808), Ilybius guttiger (Gyllenhal, 1818), Graphoderus zonatus (Hoppe, 1795), Gyrinus suffriani Scriba, 1855, Hydrochus megaphallus Berge Henegouwen, 1988, Cercyon hungaricus Endrődy-Younga 1967, Laccobius simulatrix d’Orchymont, 1932, Enochrus ater (Kuwert, 1888) and E. hamifer (Ganglbauer, 1901).
Additional data to the hister beetle fauna of Turkey (Coleoptera: Histeridae)
Authors: Rozner István
Published: March 2023

Between 1977 and 2001 the Hungarian Entomological Society organised 9 collecting trips to Turkey. During these trips 56 species of 14 genera in 5 sub-families were collected. Beside several rare species Hypocaccus rugiceps (Duft,) was also captured and it proved to be a new record for Turkey.
Two new Tenthredo species from Bhutan (Hymenoptera: Tenthredinidae)
Authors: Haris Attila
Published: March 2023

Tenthredo wangduensis spec. nov. and Tenthredo feijeni spec. nov. are described from Bhutan and compared to Tenthredo valvicepata Singh and Saini, 2005 and Tenthredo lissuana Malaise, 1945.
Diet of Eurasian otters (Lutra lutra) in natural habitats of the Gemenc Area (Danube-Drava National Park, Hungary) in early spring period
Authors: Lanszki József , Mórocz Attila , W. H. Conroy Jim
Published: March 2023

The relationship between the food web and interspecific trophic levels are less well understood along the Hungarian section of the Danube River. In this study, the diet composition of the Eurasian otter (Lutra lutra) as mammalian top predator species of wetlands was examined by spraint analysis, in an early spring period at six oxbow lakes of the Gemenc Area. The primary food of otters was fish (min-max 83.9- 100.0%, biomass estimation), characteristically gibel carp. Besides fish, amphibians, crayfish and water beetles were eaten in low proportions, therefore the trophic niche was very narrow in all areas. Otters preyed primarily (>56%) on small-sized (<100g) fish, but at three areas, the consumption ratio of 100-500 g fish was also considerable. The main fish prey was eurytopic (>69%), but stagnophilic or reophilic fishes were also eaten considerably on some areas. Consumption of fish in high proportions indicates that their availability might be satisfactory for otters. However fish surveys ocassionally indicated low fish densities. Diet composition and feeding habits of otters differed between areas. It draws attention to the possible need for different conservation and management objectives of the sensitive valley flat-habitats of the Danube, an important European ecological corridor.
Climatic conditions of semi-natural habitats in Belső-Somogy, Külső-Somogy and Zselic regions I. : Climatic surface and climatic envelope of woodlands
Authors: Salamon-Albert Éva , Ortmann-Ajkai Adrienne , Horváth Ferenc , Morschhauser Tamás
Published: March 2023

In our study bioclimatic variables calculated from long-term temperature and precipitation data (1960-1990) were applied in order to define climatic surfaces and climatic envelope of significant woody habitat types in three vegetation-based hilly landscape of South Transdanubia (Belső-Somogy, Külső-Somogy, Zselic). Certain differencies can be observed in the climatic surface of the regions. Külső-Somogy is the most extreme region by all the bioclimatic indeces, Zselic is the most balanced by precipitation and Belső-Somogy is similar by the temperature indeces. Climatic envelopes of main woody habitat types (J – riverine and swamp woodlands, K – mesic deciduous woodlands, L – dry closed deciduous woodlands, R – other tree dominated habitats) are considerably overlapping by the selected bioclimatic variables. Precipitation must be a significant role in the existence of woody habitat types according to the landscape region. Values of temperature are valid in a narrower range without any differentiation by the habitats or landscapes.
The rock-heath association Helleboro odori-Spiraeetum mediae in the Villány Mts (South Hungary)
Authors: Erdős László , Morschhauser Tamás
Published: March 2023

The rock-heath association Helleboro odori-Spiraeetum mediae has not been studied in the Villány Mts so far. In this article, we characterize the stands of the Szársomlyó Mt and compare them to the stands of the Mecsek Mts. In general, the stands are very similar in vegetation structure, ecological indicator spectra and social behaviour type spectra, although there are some differences in species composition.
Sara Levy i jej muzyczna kolekcja. Koncerty klawiszowe Carla Philippa Emanuela Bacha z Biblioteki Narodowej 1
Authors: Görny Tomasz
Published: March 2023

Sara Levy and Her Music Collection. Keyboard Concertos by Carl Philipp Emanuel Bach from the National Library ofPoland
The paper discusses musical sources kept in the National Library of Poland, namely a collection of handwritten copies of ten keyboard concertos by Carl Philipp Emanuel Bach, made by Georg Amft based on materials that originated from the music collections of Sara Levy and Zippora Wulff. This paper primarily focuses on the Concerto in A Minor Wq 26. Amft’s copy of that piece was likely made based on a Bach’s autograph kept in the Royal Library in Berlin (Königliche Bibliothek). Seeing as Amft’s Vorlage is now lost, the Warsaw document appears to be an important indirect source for an early version of Wq 26.