bluuebunny/crossref_metadata_2025 huggingface dataset:
How do learning organisation and reward system affect lecturers’ innovative work behaviour?
Authors: Sulistiasih S. , Widodo Widodo
Published: October 2022

Innovative work behaviour (IWB) is essential for the survival of individuals and organisations. Therefore, this research examines IWB based on learning organisation, reward systems, and job involvement perspectives. It also proves job involvement’s role in mediating learning organisation and reward systems on IWB. A quantitative approach was adopted with a causal design, and questionnaires were administered to 230 lecturers of private universities in Indonesia to collect data. The result of path analysis showed that learning organisation, reward system, and job involvement significantly affects IWB. Job involvement also mediates the relationship between the learning organisation and rewards system with IWB. Therefore, a new model that learning organisation and reward system affects IWB mediated by job involvement is confirmed. IWB can be improved through learning organisation and reward system with the support of job involvement.

 

Keywords: learning organisation, reward system, job involvement, innovative work behaviour, lecturer.
Manual de electrocardiografía canina para estudiantes de medicina veterinaria
Authors: Sánchez Klinge Marta Elena , Venegas Cortés Carlos Alberto
Published: October 2022

En este manual se estudiarán temas y conceptos básicos, que permitirán el entendimiento de la fisiología y el funcionamiento eléctrico del corazón, con el fin de comprender la forma correcta de tomar un electrocardiograma (CG) en caninos, así como su correcta lectura e interpretación. Además de esto, se tratarán temas como: los sistemas de formación y conducción de los estímulos cardíacos o sistema de conducción intrínseco del corazón, electrofisiología, la toma y lectura de electrocardiograma, entre otros.
Finite Element Analysis for the Static Response of Functionally Graded Porous Sandwich Beams
Authors: AL-ITBI Sura Kareem , NOORI Ahmad Reshad
Published: October 2022

In this paper, the finite element method is used to analyze the static response of the functionally graded porous (FGP) sandwich beams subjected to uniformly distributed loads along the beam span. The core of the beam is made up of functionally graded porous material while the top and bottom layers are made up of isotropic homogenous materials. Uniform distribution and symmetric distribution of pores are used as two different types of porous material. Shear deformation is considered in the analysis by utilizing BEAM189 in ANSYS which is a finite element package program. This element is based on the first-order shear deformation theory. The influence of porosity coefficient, boundary conditions, and type of the porous material on the static response of the considered structures is presented in detail. The results demonstrate that the porosity coefficient has an important impact on the static response of the FGP sandwich beams.
Özne ve Öteki: Thomas Hettche’nin Tavus Kuşu Adası Adlı Romanına Postkolonyal Bir Okuma
Authors: BAZARKAYA Onur Kemal
Published: October 2022

Thomas Hettche’nin 2014 yılında yayımlanan Tavus Kuşu Adası (“Pfaueninsel”) adlı romanı, 19. yüzyılda geçer ve Marie olarak bilinen, Maria Dorothea Strakon adlı kadın karakterin yaşam öyküsünü anlatır. Çocukluğunda öksüz olan Marie ve ağabeyi Christian, Berlin’in güneybatısında bulunan Tavus Kuşu Adası’na götürülüp kraliyet bakımına verilirler. Her ikisi de kısa boylu, görünürde yalnızca yetiştikleri adanın düzeninde var olabilen “cüceler”dir. Diğer insanlar, Marie ve Christian’a “canavar” gözüyle bakar ve onlarla aslında bir sömürge ilişkisi sürdürürler. Anlatıma böyle bakıldığında, hegemonyanın mikro düzeyine odaklandığı söylenebilir. Özneler arasında zorbaca davranışların nasıl ortaya çıktığını, nasıl geliştiğini ve en sonunda nasıl kurbanlara neden olduğunu resimlendirir. Bu doğrultuda makalede, roman, Homi K. Bhabha’nın postkolonyal kuramı temelinde incelenecek ve hegemonik bir ötekileştirme hikâyesi olarak okunacaktır.
Kutadgu Bilig’de “Vakt-i Subh”
Authors: UZUNTAŞ Hülya
Published: October 2022

Kutadgu Bilig Balasagunlu Yusuf tarafından Karahanlı Türkçesiyle 1069-1070 yılları arasında yazılmıştır. Kutadgu Bilig’in biri Uygur harfli, ikisi Arap harfli olmak üzere bugün bilinen üç nüshası vardır. Reşid Rahmeti Arat her üç nüshayı karşılaştırarak eserin tenkitli metin neşrini hazırlamıştır. Alegorik bir eser olan Kutadgu Bilig’de dört ana karakter üzerinden iki cihanda “mutlu olma bilgisi” verilir. Yusuf bu bilgileri verirken birtakım kavramlar arasında benzerlik ilgisi de kurarak anlatmak istediklerini okurun veya dinleyicinin zihninde canlandırır. Yusuf’un söz ustalığı sabah/gündüz ve akşam/gece tasvirlerinin yapıldığı beyitlerde de açıkça görülür. Çalışmamızda, Kutadgu Bilig’de sabah vaktinin tasvir edildiği beyitler, Arat’ın hazırladığı tenkitli metin neşrinden istifade edilerek değerlendirilecektir.
Exploring Lecturers' Perspectives on Inclusive Elementary School Mentoring Programs based on University-School Collaborative Partnerships in Indonesia
Authors: Rasmitadila  , Humaira Megan Asri , Rachmadtullah Reza , Samsudin Achmad , Nurtanto Muhammad
Published: October 2022

The purpose of this research was to explore lecturers’ perspectives on the mentoring programs conducted by inclusive elementary schools based on university-school collaborative partnerships (USCP). The government has not fully addressed the problems faced in providing inclusive education in elementary schools in Indonesia. It is necessary to involve all parties, including universities, to help solve these problems. Universities should play an important role in the implementation of inclusive education through practical ventures such as continuous mentoring programs to enable positive outcomes in inclusive elementary school education. Data were collected using in-depth interviews with seven lecturers from universities in Indonesia that have teacher education faculties. The data were analyzed using thematic analysis. The results provided insight into three areas of interest, namely the forms of mentoring activities, collaboration with inclusive elementary schools and the benefits of mentoring. An inclusive elementary school mentoring program based on university-school collaborative partnership is one that should produce mutual benefits for both parties. Universities are seen to be in a position to help inclusive elementary schools solve problems and provide appropriate solutions so that the implementation of inclusive education in elementary schools can follow government regulations. The government as the policy maker can be actively involved in evaluating inclusive education programs so that more flexible regulations can be introduced.
Biodegradable and biocompatible synthetic polymers for applications in bone and muscle tissue engineering
Authors: Tawade Pratik , Tondapurkar Nimisha , Jangale Akash
Published: October 2022

In medicine, tissue engineering has made significant advances. Using tissue engineering techniques, transplant treatments result in less donor site morbidity and need fewer surgeries overall. It is now possible to create cell-supporting scaffolds that degrade as new tissue grows on them, replacing them until complete body function is restored. Synthetic polymers have been a significant area of study for biodegradable scaffolds due to their ability to provide customizable biodegradable and mechanical features as well as a low immunogenic effect due to biocompatibility. The food and drug administration has given the biodegradable polymers widespread approval after they showed their reliability. In the context of tissue engineering, this paper aims to deliver an overview of the area of biodegradable and biocompatible synthetic polymers. Frequently used synthetic biodegradable polymers utilized in tissue scaffolding, scaffold specifications, polymer synthesis, degradation factors, as well as fabrication methods are discussed. In order to emphasize the many desired properties and corresponding needs for skeletal muscle and bone, particular examples of synthetic polymer scaffolds are investigated. Increased biocompatibility, functionality and clinical applications will be made possible by further studies into novel polymer and scaffold fabrication approaches.
Recent sightings of the Night Parrot Pezoporus occidentalis from Matuwa (Lorna Glen) and Millrose Station in Western Australia
Authors:   Department of Parks and Wildlife, Woodvale Research Centre, Locked Bag 104, Bentley Delivery Centre  WA 6983, Australia, Hamilton Neil , Onus Mike ,   Department of Parks and Wildlife, Woodvale Research Centre, Locked Bag 104, Bentley Delivery Centre  WA 6983, Australia, Withnell Bruce ,   Department of Parks and Wildlife, Goldfields Region, Kalgoorlie WA 6433, Australia, Withnell Kay ,   Department of Parks and Wildlife, Goldfields Region, Kalgoorlie WA 6433, Australia
Published: October 2022

The elusive and rare Night Parrot Pezoporus occidentalis is being continually searched for and sightings reported. It was thought possibly to be extinct until recent discoveries of two dead specimens in Queensland (1999, 2006), a confirmed sighting in the Pilbara in 2005, the first photograph of a live bird in Queensland in 2013, subsequent discoveries in western Queensland, and a photograph of a Night Parrot in flight from the interior of Western Australia in 2017. We describe our sightings of the Night Parrot from the arid region of Western Australia on 24 November and 5 December 2009. In addition, we briefly describe other possible sightings from the same location and adjoining Millrose pastoral station.
Underreporting and Triggering Factors for Two Ophthalmic Drugs’ ADR Notification; A Comparison between Spontaneous Reporting and Active Pharmacovigilance Databases
Authors: Contreras-Salinas Homero , Baiza-Durán Leopoldo Martín , Bautista-Castro Manuel Alejandro , Alonso-Rodríguez Diego Rodrigo , Rodríguez-Herrera Lourdes Yolotzin
Published: October 2022

(1)Aims of the study: calculating the underreporting ratio for two different medications, a fixed combination of 0.5% timolol + 0.2% brimonidine + 2.0% dorzolamide (antiglaucoma) and a fixed combination of sodium hyaluronate 0.1% + chondroitin sulfate 0.18% (artificial tear) and characterizing the features influencing the reporting of adverse drug reactions (ADRs) in spontaneous reporting; (2) Methods: the underreporting ratio was calculated by comparing the adverse drug reactions reported in the spontaneous reporting database for every 10,000 defined daily doses marketed and the adverse drug reactions from an active surveillance study for every 10,000 defined daily doses used for different drugs (antiglaucoma and artificial tear). The factors related to the report in spontaneous reporting through statistical tests were also determined; (3) Results: The underreporting ratio of spontaneous reporting was 0.006029% for antiglaucoma and 0.003552% for artificial tear; additionally, statistically significant differences were found for severity, unexpected adverse drug reactions, and incidence of adverse drug reactions in females; (4) Conclusions: The underreporting ratio of ADRs related to ophthalmic medications indicates worry since the cornerstone of pharmacovigilance focuses on spontaneous reporting. Besides, since underreporting seems to be selective, the role of certain aspects like gender, seriousness, severity, and unexpected ADRs, must be considered in future research.
Multiphysics Topology Optimization Using Automatic Differentiation and Adjoint Method
Authors: He Junyan , Abueidda Diab
Published: October 2022

An essential step in solving any topology optimization problem is determining the sensitivities of the objective function and optimization constraints. Unfortunately, these sensitivities are usually derived and implemented manually. Nontrivial objective functions and constraints, especially with the involvement of material and geometric nonlinearities, need strenuous mathematical derivation, leading to error-prone implementation. Another intriguing approach to finding sensitivities is automatic differentiation. This paper uses the automatic differentiation and adjoint method to find the sensitivities for two multiphysics topology optimization problems: 1) thermoelasticity and 2) piezoelectricity. This approach is not limited to these examples and can be easily extended to other single- or multi-physics topology optimization problems.
A Duality Principle and a Concerning Convex Dual Formulation Suitable for Non-convex Variational Optimization
Authors: Botelho Fabio
Published: October 2022

This article develops a duality principle and a related convex dual formulation suitable for a large class of models in physics and engineering. The results are based on standard tools of functional analysis, calculus of variations and duality theory. In particular, we develop applications to a model in non-linear elasticity.
Adversarial Patch Attack on Multi-Scale Object Detection for Remote Sensing Image
Authors: Zhang Yichuang , Zhang Yu , Qi Jiahao , Bin Kangcheng , Wen Hao , Zhong Ping
Published: October 2022

Although deep learning has received extensive attention and achieved excellent performances in various of scenarios, it suffers from adversarial examples to some extent. Especially, physical attack poses more threats than digital attack. However, existing researches pay less attention to physical attack of object detection in remote sensing images (RSIs). In this work, we systematically analyze the universal adversarial patch attack for multi-scale objects in the remote sensing field. There are two challenges for adversarial attack in RSIs. On one hand, the number of objects in remote sensing images is more than that of natural images. Therefore, it is difficult for adversarial patch to show adversarial effect on all objects when attacking a detector of RSIs. On the other hand, the wide range of height of photography platform causes that the size of objects diverse a lot, which brings challenges for generating universal adversarial perturbation for multi-scale objects. To this end, we propose an adversarial attack method on object detection for remote sensing data. One of the key ideas of the proposed method is the novel optimization of adversarial patch. We aim to attack as many objects as possible by formulating a joint optimization problem. Besides, we raise a scale factor to generate a universal adversarial patch that adapts to multi-scale objects, which ensures the adversarial patch is valid for multi-scale objects in the real world. Extensive experiments demonstrate the superiority of our method against state-of-the-art methods on YOLO-v3 and YOLO-v5. In addition, we also validate the effectiveness of our method in real-world applications.
Inner-cycle Phases can be Estimated from a Single Inertial Sensor by Long Short-term Memory Neural Network in Roller Ski Skating
Authors: Frédéric Meyer , Lund-Hansen Magne , Seeberg Trine M. , Kocbach Jan , Sandbakk Øyvind , Austeng Andreas
Published: October 2022

Objective: The aim of this study was to provide a new machine learning method to determine temporal events and inner-cycle parameters (e.g., cycle, poles and skis contact and swing time) in cross-country roller ski skating on the field, using a single deported inertial measurement unit (IMU). Methods: The developed method is based on long short-term memory neural networks to detect poles and skis initial and final contact with the ground during the cyclic movements. Eleven athletes skied four laps of 2.5 km at low and high intensity using skis with two different rolling coefficients. They were equipped with IMUs attached to the upper back, lower back and to the sternum. Data from force insoles and force poles were used as reference system. Results: The IMU placed on the upper back provided the best results, as the LSTM network was able to determine the temporal events with an accuracy ranging from 49 to 55 ms and the corresponding inner-cycles parameters were calculated with a precision of 63 to 68 ms. The method detected 95% of the events for the poles and 87% of the events for the skis. Conclusion: The proposed LSTM method provides a promising tool for assessing temporal events and inner-cycle phases in roller ski skating showing the potential of using a deported IMU to estimate different spatio-temporal parameters of human locomotion.
Steel Slag as a Precursor Material for Alkali-Activated Binders: A Systematic Review.
Authors: Borba Jr. José C. , Brigolini Guilherme J. , Oliveira Victor A. A. , Calmon João L. , Mariano Eduardo F.
Published: October 2022

Steel slag is a co-product of the steelmaking industry, this material is rarely used as a binder due to its low cementitious properties. Thus, it´s believed that the alkaline activation of steel slag can enable its use as a cementitious material. This work has the objective of making a systematic bibliographic review on the theme "slag melt as a precursor in activated alkali binders". To this end, the ProKnow-C method was used for the selection and analysis of relevant research on the topic. The portfolio resulted in 71 texts, mostly journals paper. Bibliometrics showed that the country with the most publications is China and the journal with the most publications is Construction and Building Materials. The critical analysis concluded that the XRD, XRF, and compressive strength tests are the most used for the characterization of the material. It is possible to establish that there are some knowledge gaps on the subject, such as better mechanical characterization and greater production of works with dosing by the one-part method.
AtbFinder Diagnostic Test System Improves Optimal Selection of Antibiotic Therapy in Persons with Cystic Fibrosis
Authors: Tetz George , Kardava kristina , Vecherkovskaya Maria , Hahn Andrea , Tsifansky Michael , Koumbourlis Anastassios , Tetz Victor
Published: October 2022

Cystic fibrosis (CF) is characterized by mutations of CFTR that lead to increased viscous secretions, bacterial colonization and recurrent infections. Chronic P. aeruginosa infection in persons with CF is associated with progressive and accelerated lung function decline despite aggressive antibiotic treatment. We report the management of respiratory infections in persons with CF with antibiotic therapy that was based on the recommendations of AtbFinder, a novel, rapid, culture-based diagnostic test system that employs a novel paradigm of antibiotic selection. AtbFinder mimics bacterial interactions with antibiotics at concentrations that can be achieved in affected tissues or organs, and models conditions of interbacterial interactions within polymicrobial biofilms. This open-label, single-arm, investigator‐initiated clinical study was designed to identify the efficacy of antibiotics selected using AtbFinder in persons with CF. Microbiological and clinical parameters were assessed following the change of antibiotic therapy to antibiotics selected with AtbFinder between January 2016 and December 2018 and retrospectively compared with clinical data collected between January 2013 and December 2015.We enrolled 35 persons with CF (33 with chronic P. aeruginosa colonization). Antibiotics selected using AtbFinder resulted in clearance of P. aeruginosa in 81.8% of subsequent cultures, decreased pulmonary exacerbations from 1.21 per patient per annum to 0, and an increase in predicted FEV1% up to 28.4% from baseline. The number of systemic antibiotic courses used in patients after switching to the AtbFinder selected therapy was reduced from 355 to 178. These findings describe the superiority of antibiotic regimens selected with AtbFinder compared with routine antimicrobial susceptibility testing.
Employ of Anthocyanins in nanocarriers for Nano Delivery: In Vitro and In Vivo Experimental Approaches for Chronic Diseases
Authors: Gonçalves Ana C. , Falcão Amícal , Alves Gilberto , Lopes João A. , Silva Luís R.
Published: October 2022

Anthocyanins are among the best-known phenolic compounds and possess remarkable biological activities, including antioxidant, anti-inflammatory, anticancer, and antidiabetic effects. Despite their therapeutic benefits, they are not widely used as health-promoting agents due to their insta-bility, low absorption, and thus, low bioavailability and rapid metabolism in the human body. Recent research suggests that the application of nanotechnology could increase their solubility and/or bioavailability, and thus, their biological potential. Therefore, in this review, we decided to provide, for the first time, a comprehensive overview of in vitro and in vivo studies on nanocarriers used as delivery systems of anthocyanins, and their aglycones, i.e., anthocyanidins alone or com-bined with conventional drugs to the treatment or management of chronic diseases.
The Perception of Tourism Sustainability by Stakeholders. The Case Study of the “Sierra de Aracena y Picos de Aroche” Nature Park, “Sierra Norte de Sevilla” Nature Park and “Sierra de Hornachuelos” Nature Park (Andalusia, Spain)
Authors: Bahamonde-Rodríguez María , García-Delgado F. Javier , Šadeikaitė Giedrė
Published: October 2022

As a form of protection, a nature park is often created to protect and valorise natural and cultural heritage in peripheral rural areas. However, in terms of multi-functionality, new nature parks are incorporated into traditional productive activities, such as recreational and tourist activities, which sometimes compromise sustainability. The research objective is to study the relationship between tourism and sustainability in the Nature Parks of “Sierra de Aracena y Picos de Aroche”, “Sierra Norte de Sevilla” and “Sierra de Hornachuelos” that makes up the Dehesas de Sierra Morena Biosphere Reserve in Andalusia, Spain. Therefore, selective interviews have been carried out with the stakeholders to establish their perception of sustainable tourism and the presence of dominant discourses. The main conclusions indicate (1) the presence of different dominant discourses on sustainability, namely the conservationist and mercantilist ones, with the prevalence of the economic dimension; (2) poor awareness and adaptation to the context of global change; and (3) the presence of competitive relationships that generate difficulties for the governance of sustainable tourism.
1831 Nüfus Sayımına Göre Tarsus Sancağı İdarî Durum, Yerleşme ve Nüfus
Authors: UĞUZ Sacit , GECEKUŞU Bilge
Published: October 2022

Osmanlı Devleti klasik dönemde toprakları üzerinde yaşayan nüfusu mali açıdan denetlemek amacıyla belirli aralıklarla tahrirler yapmıştır. Bu tahrirler, günümüz araştırmacılarına, iktisadi durumun yanında dönemin demografik ve sosyal yapısı ile ilgili de önemli veriler sunmaktadır. XIX. yüzyıla gelindiğinde, çağın gerekleri doğrultusunda devletin ihtiyaç duyduğu istatistiki verileri elde etmek amacıyla nüfus sayımları gerçekleştirilmiştir. Bu kapsamda 1831’de yapılan ve ülkenin asker potansiyelini belirleme amacı taşıyan nüfus sayımı, Osmanlı Devleti’nin modern manada gerçekleştirdiği ilk nüfus sayımı olarak kabul edilmektedir. Bu çalışmanın ana kaynağını teşkil eden 1832 tarihli Tarsus nüfus defterleri bu sayım neticesinde tutulmuştur.
Tarsus Sancağının nüfus verilerini ihtiva eden dört adet defterin incelenmesi neticesinde, öncelikle sancağın idarî durumu ortaya konmuştur. Bu kapsamda köyler kazalara göre tasnif edilerek yerleri tespit edilmiş ve kazaların sınırları belirlenerek haritalandırılmıştır. Ardından yerleşmeler sınıflandırılmış, şehir merkezindeki mahalleler ve kazalara bağlı köyler hakkında bilgiler verilmiştir. Son olarak da sancağın demografik durumu ele alınmış, mahalleler, kazalar ve köylerin ayrı ayrı nüfus bilgileri üzerinde durulmuştur. Ayrıca defterlerde yer alan aşiret ve cemaatlerin nüfusları da bu kapsamda incelenmiştir. Elde edilen bütün bu veriler ışığında Tarsus Sancağının İbrahim Paşa işgalinin hemen öncesine rastlayan dönemde idari ve demografik özellikler ortaya konmaya çalışılmıştır.
Integrando lo disociado: Del dominio del miedo al poder de la angustia. La angustia como una "presencia del sentimiento"
Authors: Loaicono Anna María
Published: October 2022

The author addresses contemporary clinical practice, where we encounter individuals, seemingly incapable of getting in touch with their own existential dimension, who communicate their detachment, at times even total, from their feelings and fears, wilfully committed as they are to avoid experiencing the inevitable angst that may accompany them through life. This dissociation from the angst-producing emotion is revealed to the clinician through either detachment or a simple action. This feeling that generates both detachment and its opposite, perhaps a hypomanic reaction, proves to be “absent,” and is not perceived by the patient. In this way, angst can be avoided and indeed seems “absent,” but what is experienced is the complete range of raw emotions connected to it, such as fear, terror, panic, detachment, apathy, and anhedonia. The author sets out to clarify the terms “fear,” “anxiety,” and “angst” as they have been historically used in philosophy, psychoanalysis, psychiatry, and psychology. Ultimately, she explains her reason for her choice of the word “angst” instead of “anxiety” in her distinct and explicit handling of this subject matter.
Kemampuan Basic Knolwledge Guru Sekolah Dasar Peserta Program Pendidikan Profesi Guru
Authors: Wardani Rizki Putri , Fitriyah Chumi Zahroul
Published: October 2022

The Teacher Certification Program was an educational form that aimed at increasingthe professionalism of teachers. The aim of this research was to describe before and after basic knowledge of primary teachers that has been already joining in Teacher Certification Program. Basic knowledge is knowledge about understanding lesson plans which is suitable with basic competence, lesson theory, until research plan after teaching to support teacher professionalism. The research method was a quantitative description. Technique this research was an interview with a primary teacher that has been already joining the teacher certification program. Data analysis using a percentage of basic knowledge before and after primary teacher. Data result has been shown basic knowledge primary teacher is increased from arranging lesson plan for doing research and reflection in the learning process

 

Pendidikan Profesional Guru merupakan bentuk pendidikan yang ditujukan bagi guru untuk meningkatkan keprofesionalan guru. Tujuan dari penelitian ini untuk mendeskripsikan kemampuan dasar atau Basic Knowledge guru Sekolah Dasar sebelum dan sesudah mengikuti Pendidikan Profesional Guru (PPG). Kemampuan dasar atau basic knowledge merupakan kemampuan yang meliputi pemahaman rencana pembelajaran yang sesuai kompetensi dasar, pemahaman teori belajar, hingga penelitian setelah pembelajaran untuk mendukung profesional guru. Metode dalam penelitian ini adalah deskriptif kuantitatif. Teknik wawancara dilakukan dalam penelitian ini dengan subjek guru sekolah dasar yang telah megikuti PPG. Analisis data menggunakan hasil presentasi kemampuan guru sebelum dan sesudah mengikuti PPG. Hasil penelitian menunjukkan bahwa kemampuan Basic Knowledge guru Sekolah Dasar meningkat, dimulai dari kemampuan melakukan perencanaan sampai melakukan penelitian perbaikan dalam pembelajaran.
MTMC: A Scheduling Framework of Multi-Tasking Mapping on Multi-Chips
Authors: Yao Jinyang , Wang Junchao , Yue Feng , Xu Jinlong , Shan Zheng
Published: October 2022

Currently, accessing quantum chips through the quantum cloud is the conventional way for most researchers to use quantum computers. In the case of limited quantum chip resources, improving the overall utilization of quantum chips can provide advantages from using quantum computer systems. At present, the main method to improve resource utilization is through multiprogramming on one quantum chip by putting multiple programs on one quantum chip for execution. A scheduling framework of multitasking mapping on a multichip is proposed in this paper. This framework is deployed in the later stage of the quantum computing compiler. Moreover, this framework can unify all candidate chips in the cloud platform into a computing resource pool and automatically allocate computing resources for users, which improves the overall efficiency of quantum computers and further simplifies the steps for users to use quantum computers.
Human endometrium derived induced pluripotent stem cells are amenable to directed erythroid differentiation
Authors: Kim Hyun Kyung , Cho Si Hyun , Choi Young Sik , Lee Byung Seok , Kim Sinyoung , Kim Hyun Ok , Park Joo Hyun
Published: October 2022

Background: With the consistent increase in life-expectancy, excavating novel sources of regenerative medicine is an important objective to enhance disease free life expectancy. A comprehensive protocol for using human endometrium derived induced pluripotent stem cells to derive hematopoietic and erythroid lineages will be elaborated, through a two-phase culture system.
Method: Discarded endometrial tissues were obtained from women receiving hysterectomy in their 4th to 5th decade due to benign uterine conditions. The endometrial cells isolated were expanded to passage 3-4 to allow stromal cells to dominate in the culture environment. pCE-Sox2, Oct4, Klf4, L-Myc and Lin28 episomal vectors were used to electrotransfection the endometrial stromal cells. The erythroblast differentiation of these established induced pluripotent stem cells (iPSCs) were conducted in two phases. The first 8 days involves commitment to hematopoietic stem cells through embryoid body with robust expansion on murine bone marrow stromal cells. The second phase involves feeder free conditions with hydrocortisone, stem cell factor, interleukin-3, and recombinant EPO. After 22 days of feeder free culture, the expression profiles of CD235a+, CD34+, CD43+ and CD 71+ were analyzed by flow cytometry and Wright-Giemsa staining for differential counting. The oxygen carrying capacity of cultured RBCs was measured using a hemoxanalyser.
Results: As a result of inducing these cells via co-culture with murine stromal fibroblasts, all endometrium derived iPSCs were differentiated into erythroblasts with stably yielding over 80% of polychromatic and orthochromatic normoblast. The protocol for complete induction of erythroid lineage cells starting from human endometrial tissue via iPS cells has been optimized.
Conclusion: Successful induction of hematopoietic cell fate followed by erythroid differentiation up to erythroblast were achieved in an effort to develop transfusion source. And a complete process of actually deriving iPS cells with discarded surgical hysterectomy specimens has significance in the possibility of expanding the scope of use of theses iPSC cell lines in the future.
Start small and let it build; a mixed-method evaluation of a school-based physical activity program, Kilometre Club
Authors: Schirmer Teisha , Bailey Andrew , Kerr Nicola , Cecilio Michael , Ferrington Linda , Walton Alison
Published: October 2022

Background
Despite the benefits of physical activity, there is minimal research focusing on factors that influence grassroots school-based physical activity programs. Kilometre (KM) Club is an Australian grassroots program which aims to increase physical activity in students through the completion of an outside walk or run at school. This study aimed to examine the benefits, enablers and barriers of KM Club. It also aimed to examine the effects of KM Club on student’s physical activity levels during the school day.
Methods
Four regional NSW primary schools participated in this study. 26 families, four teachers, and two principals completed semi-structured interviews to understand their perceptions of KM Club.
21 students completed emotional state-scales to understand their emotions when participating in KM Club. 141 students participated in step-count measures using accelerometers.
Results
Families, teachers and principals reported a range of benefits such as improved fitness levels, participation in sports, social connectedness, eagerness to learn, concentration, home and classroom behaviours and wellbeing outcomes. Enablers consisted of champion engagement, incentives, versatile facilities and integration with other school activities. Barriers consisted of weather and environment, program timing and health issues. Most students reported that participating in KM Club made them feel proud, confident and fantastic. School B reported a significant increase in students' daily step counts on KM Club days compared to non-KM Club days (+15%; p<0.001). School C reported no significant increase in students' daily step counts on KM Club days compared to non-KM Club days (-5%; p<0.26). School D reported a significant increase in the number of daily steps taken by KM Club participants compared with non-KM club participants (+10%; p=0.024).
Conclusion
There is no one-size-fits-all approach to implementing school-based physical activity initiatives. However, it appears that flexible and adaptable factors are important to the successful implementation of school-based programs, such as KM Club. This study revealed a variety of self-reported health, wellbeing and educational benefits for students, as well as an increase in student’s physical activity levels at 2/3 schools. This evidence may help to inform future design, implementation and scale-up of KM Club and school-based health promotion programs, potentially improving child health, wellbeing and educational outcomes.
Trial registration
(LNR223 – LNR/19/NCC/45)
Evaluation of biochemical parameters and some antioxidants indicators in lactating Nubian and Karachai goats under Russian conditions
Authors: Trukhachev Vladimir , Aybazov Ali-Magomet , Mamontova Tatyana , Bogolyubova Nadezhda , Sermyagin Alexander , Rykov Roman , Selionova Marina , Zinovieva Natalia , Imbabi Tharwat
Published: October 2022

The study’s aim was to assess determine the physiological and biochemical status of lactating Nubian and Karachai goats depending on breed and lactation number, as well as to identify correlations between blood biochemical parameters and some antioxidant indicators. Our experiment was divided into two groups for this purpose: the first (comparative group) included Nubian goats (n= 22) and Karachai goats (n= 67), while the second (general group) included Nubian goats (n= 43) and Karachai goats (n= 93). In the comparative group, the levels of total protein, urea, alanine amino transferase (ALT), glucose, total bilirubin, alkaline phosphatase and thiobarbituric acid reactive substances (TBARS), calcium, phosphorus and magnesium were significantly higher in Karachai goats compared to Nubian goats. In the comparable group, lactation number had a significant effect on calcium and alkaline phosphatase but had no effect on other parameters. Correlations were moderately positive between TBARS level and albumin (0.34), cholesterol (0.34), alkaline phosphatase (0.39), phospholipids (0.43), and calcium (0.35) in Nubian goats. On the other hand, were found moderate negative correlations between ceruloplasmin level and albumin (-0.30), A/G (-0.37), magnesium (-0.35), and the total content of water-soluble antioxidants (TAWSA) (-0.40) in Nubian goats. In Karachai goats, there were moderate positive correlations between TBARS level and albumin (0.41), phospholipids (0.41). However, there was found a very strong negative correlation between ceruloplasmin level and TBARS/CP ratio (-0.67). Total protein, albumin, and ceruloplasmin levels in the general group increased as lactation number increased. Aspartate amino transferase (AST), TBRAS, and TBRAS/CP levels were decreased after the second lactation, and TAWSA decreased from I to IV lactation. Moderate positive correlations between TBARS and albumin (0.44), total protein (0.32), and magnesium (0.33). On the other hand, moderate negative correlations were established between ceruloplasmin level and total protein (-0.30), bilirubin (-0.43), triglycerides (-0.32), ALT (-0.30), TAWSA (-0.31).
Age of Diagnosis for Children with Chromosome 15q Syndromes
Authors: Wheeler Anne , Gantz Marie G. , Cope Heidi , Strong Theresa V. , Bohonowych Jessica E. , Moore Amanda , Vogel-Farley Vanessa
Published: October 2022

Objective: The objective of this study was to identify the age of diagnosis for children with one of three neurogenetic conditions resulting from changes on chromosome 15 (Angelman syndrome [AS], Prader-Willi syndrome [PWS], and Duplication 15q syndrome [Dup15q]).
Methods: Data about diagnostic process for each condition were contributed by the advocacy organizations. Median and interquartile ranges were calculated for each condition by molecular subtype and year. Comparison tests were run to explore group differences.
Results. The median age of diagnosis was 1.8 years for both AS and Dup15q. PWS was diagnosed significantly younger at a median age of 1 month. Deletion subtypes for both PWS and AS were diagnosed earlier than nondeletion subtypes, and children with isodicentric duplications in Dup15q were diagnosed earlier than those with interstitial duplications.
Conclusion. Understanding variability in age of diagnosis for chromosome 15 disorders is an important step in reducing the diagnostic odyssey and improving access to interventions for these populations. Results from this study provide a baseline by which to evaluate efforts to reduce the age of diagnosis for individuals with these conditions.
Feature augmentation based on information fusion rectification for few-shot image classification
Authors: Wang Hang , Tian Shengzhao , Fu Yan , Zhou Junlin , Liu Jingfa , Chen Duanbing
Published: October 2022

In the issue of few-shot image classification, due to lack of sufficient data, directly training the model will lead to overfitting. In order to alleviate this problem, more and more methods focus on non-parametric data augmentation, which uses the information of known data to construct non-parametric normal distribution to expand samples in the support set. However, there are some differences between base class data and new ones, and the distribution of different samples belonging to same class is also different. The sample features generated by the current methods may have some deviations. A new few-shot image classification algorithm is proposed on the basis of information fusion rectification (IFR), which adequately uses the relationship between the data (including the relationship between base class data and new ones, and the relationship between support set and query set in the new class data), to rectify the distribution of support set in the new class data. In the proposed algorithm, feature of support set is expanded through sampling from the rectified normal distribution, so as to augment the data. Compared with other image augmentation algorithms, the experimental results on three few-shot datasets show that the accuracy of the proposed IFR algorithm is improved by 0.93%-3.22%.
Determination of resistance mechanisms to water deficit induced during the flowering stage in twelve varieties of cotton (Gossypium hirsutum L.) in Togo.
Authors: KOFFI Kokou Zovodu , BOKOBANA Atalaèsso , AZIADEKEY Mawuli , GNOFAM Nambou , AKANTETOU Komlan Pikassalé , AYEVA Bassarou , YORIKOUME Kondi , BOUKARI Atani Arzouma
Published: October 2022

Background: One of the limiting factors of cotton production in West Africa and more particularly in Togo is drought. Identifying the resistant varieties and understanding the mechanisms involved in their resistance is a major asset for the breeder. In this context, twelve (12) varieties of cotton (Gossypium hirsutum) were studied under two water regimes (normal and deficit during flowering), in 30 L plastic pots, under controlled sowing conditions, following a split-plot design with three replications. The induction of water deficit consisted of a decrease in irrigation from 70% to 30% of the total available water (TAW) for thirty (30) days. Observations were made on agromorphological and biochemical characteristics.
Result: The results showed that decreased water deficit decreased seed cotton production, aerial and root biomass, vegetative branches bolls, and chlorophyll content. On the other hand, the water deficit increases the average weight of the bolls. The resistant varieties to the water deficit were characterized by an increase in the main root length (X148), the chlorophyll content (STONE 907), the secondary roots number, and proline content (BRS 286), and a decrease in the MDA content (STONE 907). The susceptible varieties were characterized by high MDA content (NTALL88) and a low secondary root number (Deltatpine SL Frego).
Conclusion: The varieties STONE 907, BRS286, and X148 can be used as progenitors in crossing programs to improve the water deficit resistance of cotton varieties grown in Togo and West Africa countries.
Klebsiella pneumoniae aggravates lung injury through ethanol production
Authors: Cui Jinghua , Xu Ziying , Yu Zihui , Zhang Qun , Liu Shiyu , Du Bing , Gan Lin , Yan Chao , Xue Guanhua , Feng Junxia , Fan Zheng , Fu Tongtong , Feng Yanling , Zhao Hanqing , Ding Zanbo , Li Xiaoran , Zhang Rui , Cui Xiaohu , Tian Ziyan , Huang Kewu , Wang Wenjun , Bai Yu , Zhou Haijian , Sun Ying , Ke Yuehua , Yuan Jing
Published: October 2022

Klebsiella pneumoniae, a major pathogen leading to severe pneumonia, causes clinical complications in nosocomial and community-acquired infections. We have previously reported that high alcohol-producing K. pneumoniae (HiAlc Kpn) in the gut microbiome are strongly associated with nonalcoholic fatty liver disease (NAFLD) owing to the excess endogenous alcohol production. In the present study, we discovered that Kpn isolated from sputum and bronchoalveolar fluid (BALF) of patients with pneumoniae and chronic obstructive pulmonary disease (COPD) could also produce excess ethanol. In a murine model, HiAlc Kpn aggravated lung injury of mice with acute infection comparing with alcohol dehydrogenase gene-knockout mutant. A single-cell sequencing transcriptome analysis showed that resistin like gamma (Retnlg) neutrophil played a critical role during acute infection. The HiAlc Kpn inactivated Retnlg neutrophils in an ethanol production-dependent manner in mice, which counteract immune defense possibly through down-regulating pyrimidine and modifying DNA methylation. Furthermore, data also showed that HiAlc Kpn inhibited interleukin 1 receptor antagonist (IL1RN) gene expression by neutrophils, thereby activating IL-1β to orchestrate immune responses. Understanding functions of Retnlg neutrophils and IL-1β release in the context of HiAlc Kpn and host interactions are essential for developing novel therapeutic strategies.
Six years mortality associated with living alone and loneliness in Swedish men and women born in 1930
Authors: Novak Masuma , Waern Margda , Johansson Lena , Zettergren Anna , Ryden Lina , Wetterberg Hanna , Sterner Therese Rydberg , Fässberg Madeleine Mellqvist , Gudmundsson Pia , Skoog Ingmar
Published: October 2022

Background
This study examined how living alone and loneliness associate with all-cause mortality in older men and women.
Methods
Baseline data from the Gothenburg H70 Birth Cohort Studies, collected on the 1930 birth cohort during 2000 (70-year-olds) and 2005 (new recruits, 75-year-olds) were used for analyses (N = 778, 353 men, 425 women). Six-year mortality was based on national register data.
Results
At baseline, 36.6% lived alone and 31.9% reported feelings of loneliness. A total of 72 (9.3%) participants died during the 6-year follow-up period. Cumulative mortality rates per 1000 person-years were 23.9 for men and 9.6 for women. Mortality was increased more than twofold among men who lived alone compared to men living with someone (HR 2.40, 95% CI 1.34–4.30). Elevated risk remained after multivariable adjustment including loneliness and depression (HR 2.56, 95% CI 1.27–5.16). Stratification revealed that mortality risk in the group of men who lived alone and felt lonely was twice that of their peers who lived with someone and did not experience loneliness (HR 2.52, 95% CI 1.26–5.05). In women, a more than fourfold increased risk of mortality was observed in those who experienced loneliness despite living with others (HR 4.52, 95% CI 1.43–14.23).
Conclusions
Living alone was an independent risk factor for death in men, and mortality was doubled in men who lived alone and felt lonely. In contrast, mortality was particularly elevated in women who felt lonely despite living with others. Gender needs to be taken into account when considering the health consequences of living situation and loneliness.
A population-based survey of FBN1 variants in Iceland reveals underdiagnosis Marfan syndrome
Authors: Sulem Patrick , Arnadottir Gudny , Jensson Brynjar , Jonasdottir Adalbjorg , Katrinardottir Hildigunnur , Fridriksdottir Run , Jonasdottir Aslaug , Sigurdsson Asgeir , Gudjonsson Sigurjon , Jonsson Jon , Stefansdottir Vigdis , Danielsen Ragnar , Palsdottir Astridur , Jonsson Hakon , Helgason Agnar , Magnusson Olafur , Thorsteinsdottir Unnur , Björnsson Hans , Stefansson Kari , Klemenzdottir Elin
Published: October 2022

Marfan syndrome is an autosomal dominant condition characterized by aortic aneurysm, skeletal abnormalities, and lens dislocation, and is caused by mutations in the FBN1 gene. To explore causes of Marfan syndrome and the prevalence in Iceland we collected samples and information from all living individuals with a clinical diagnosis of Marfan syndrome in Iceland (n = 35) and performed whole-genome sequencing of those who did not have a confirmed genetic diagnosis. Moreover, to assess a potential underdiagnosis of Marfan syndrome in Iceland we attempted a genotype-based approach for identifying individuals with Marfan syndrome. We interrogated deCODE genetics’ database of 35,712 whole-genome sequenced individuals to search for rare sequence variants in FBN1. Overall, we identified 15 pathogenic or likely pathogenic variants in FBN1 in 41 living individuals, only 22 of whom were previously diagnosed with Marfan syndrome. The most common of these variants, NM_000138.4:c.8038C > T (p.Arg2680Cys), is present in a multi-generational pedigree, and was found to stem from a single forefather born around 1840. The p.Arg2680Cys associates with a form of Marfan syndrome that seems to have an enrichment of abdominal aortic aneurysm, suggesting that this may be a particularly common feature of p.Arg2680Cys-associated Marfan syndrome. Based on these combined genetic and clinical data, we estimate a Marfan syndrome prevalence of at least 1/6,000 in Iceland, compared to 1/10,000 based on clinical diagnosis alone, which indicates underdiagnosis of this actionable genetic disorder.