bluuebunny/crossref_metadata_2025 huggingface dataset:
Time travel from Berlin to Gdańsk: Daniel Nikolaus Chodowiecki’s 18th century journey revisited – contemporary renderings and Interpretations
Authors: Schultz Anna , Wróblewska Marta
Published: December 2024

Daniel Nikolaus Chodowiecki’s journey on horseback from Berlin to his hometown Danzig in 1773 is well documented through a diary and a carefully constructed series of more than 100 drawings. These give valuable insights into the artist’s observations and serve as rare documents of a city and landscape which was lost and in part reconstructed. As a man of diverse cultural roots, Chodowiecki also attempted to position himself within a rapidly changing political framework and, through his images, addressed questions of cultural affiliations and identity. In this, he was as much a forbearer of European ideals, as an inspiration and starting point for a group of Polish artists who in 2018 embarked on a journey in the his footsteps and, reflecting on Chodowiecki’s journal and his drawings, created works, which underline the value of the source materials, whilst picking up on issues such as the transient role of cultural identity, the changing face of travel in a more global yet deeply divided society, or issues of displacement – which remain equally relevant to this day.
The feminist street art from the western part of Mexico: The art of Mónica Barajas
Authors: Rojek Karolina
Published: December 2024

The aim of the article is to describe and analyse the street art of a Mexican artivist and curator, Mónica Barajas. Her work provides an example of how the art is able to inform and educate the public of Colima that otherwise would not learn about current social problems as they are quite often silenced by the local government.
The Association Between Loneliness and Depression in Adolescents with Self-harm at a Vocational High School in Kabupaten Malang
Authors: Puspa Maharani  , Izzatul Fithriyah  , Ivana Sajogo
Published: December 2024

Introduction: Adolescents with self-harm behavior are in the spotlight because they are increasing nowadays. Various studies have shown a relationship between self-harm and affective disorders, one of which is depression. Adolescents are also subjects who are prone to feeling lonely. This study was conducted to determine the association between loneliness and depression in adolescents with self-harm behavior at Vocational High School in Kabupaten Malang. Methods: This study used an observational analytic cross-sectional study design with a consecutive sampling technique. The population and sample were students in the 10th and 11th grades (14-18 years old) at a Vocational High School in Kabupaten Malang. Self-harm behaviors are questioned using the Self-Harm Inventory (SHI). Loneliness levels are measured using the UCLA Loneliness Scale Version-3 (UCLA-3). Meanwhile, depression rates are evaluated using the Patient Health Questionnaire -9 (PHQ-9). Statistics will be tested using Chi-square analysis. Results: Approximately 25% of subjects tended to do self-harm, and 101 of them had mild symptoms of depression. The results of the chi-square independence test showed that χ2(4)=253.663 p=0.000. A moderate degree of loneliness was experienced by 32.31% of students or as many as 95 students. The chi-square independence test showed that χ2(3)=216.359 p=0.000. Discussion: Few research, nevertheless, have painted a picture of adolescent loneliness, suggesting that both loneliness and depression may be risk factors for young people to harm themselves. This study showed a strong correlation between loneliness and self-harm. Conclusion: There was a significant correlation between self-harm, depression and loneliness.
Keywords: Loneliness, Self-Harm, Depression, Adolescent, Mental Health
Internet Addiction Leads to Loneliness or Loneliness Leads to Internet Addiction?
Authors: Triana Budi Lestari
Published: December 2024

Introduction: Internet users in Indonesia are growing from year to year. Based on the latest data from the Indonesian Internet Service Provider Association, known as Asosiasi Penyelenggaraan Jasa Internet Indonesia (APJII), in 2022, internet users in Indonesia reached 210 million. With a large number of internet users, there are positive and negative consequences that occur. Internet addiction began to be studied by many researchers. These studies include research on the factors that cause internet addiction, as well as its correlation with loneliness. To explain the correlation between internet addiction and loneliness. Methods: Literature review. Results: Loneliness is a complex and usually unpleasant emotion that is thought to be a factor in individuals experiencing internet addiction. Loneliness is the thought of loss and dissatisfaction that occurs due to a mismatch between the individual’s social interaction and the social interaction one expects. Hence to overcome the loneliness that is felt, individuals express themselves better in cyberspace than in person. Internet addiction is a condition in which internet users use the internet excessively, due to a lack of self-control and interferes with their daily tasks and functions, to the detriment of themselves. This sums in several negative consequences. Studies showed that internet addiction and loneliness are correlated and mutually reinforcing. Conclusions: The relationship between loneliness and internet use is bidirectional in the sense that just as the internet may drive individuals towards loneliness, loneliness can also encourage individuals to spend more time on the internet.
Keywords: Internet Addiction, Loneliness
Loneliness and Back Pain
Authors: Suksmi Yitnamurti  , Agustina Konginan
Published: December 2024

Introduction: Back pain is a common reason for being absent from work and seeking medical treatment. It can result from injury, activity, and some medical conditions. Back pain consists of lower back pain and upper back pain. Back pain does have a physical cause, but it can also be triggered by precipitating factors, namely loneliness. To explain the mechanism that associates back pain with loneliness. Methods: Literature review. Results: Loneliness is divided into 2 types, namely social loneliness and emotional loneliness. Social loneliness is associated with the absence of a social network from the same circle, with which they can share the same activities or interests. Emotional loneliness can arise due to the absence of close emotional attachment. Whether or not back pain persists depends on whether the individual chooses problem-solving or problem avoidance. Loneliness in several studies increases the morbidity rate of physical and mental illness and also the mortality rate. Early detection of somatic symptoms and loneliness requires a self-measurement scale. Therapeutic interventions aimed at increasing social connection hold merit in reducing the impact of pain on engagement with activities. The treatments are usually Cognitive Behavioral Therapy (CBT) and Antidepressants. If necessary, consulting a psychiatrist is recommended. The cooperation of orthopedists, rheumatologists, and physical therapists with psychiatrists can be useful in improving the condition of patients. Conclusions: Recommendations for management are needed both in terms of general and specific strategies, as well as loneliness interventions.
Keywords: Loneliness, Back Pain, Good Health and Wellbeing
Tips and tricks for the robotic-assisted approach to colorectal cancer liver metastases
Authors: Acidi Belkacem , Haddad Antony , Tran Cao Hop S.
Published: November 2024

Colorectal cancer remains a leading cause of cancer-related morbidity and mortality, with liver metastases being a critical determinant of survival. The management of colorectal liver metastases (CRLM) has historically been challenging due to the complexity of hepatic resections and the need for precision to ensure patient safety and optimal outcomes. Recently, robotic hepatectomy has emerged as a pivotal evolution in minimally invasive surgery, offering a new tool in the treatment of CRLM. This article aims to share some tips and tricks accumulated by our surgical experience in robotic resections of CRLM that have been instrumental in optimizing both outcomes and safety. We explore the multifaceted approach required for successful robotic surgery. A meticulous preoperative evaluation sets the stage for successful robotic liver surgery, where we tailor anesthesia and patient positioning based on tumor location to complement the robotic platform. During surgery, the selection of specialized instruments along with nuanced parenchymal transection techniques is guided by a number of factors, including the quality of the liver and experience of the surgeon. Incremental progression from less to more complex hepatectomies is made possible by adherence to key principles of minimally invasive liver surgery, thoughtful preparation, and surgical precision. Ultimately, this article will contribute to surgeons’ understanding of these principles and practical elements that can help to improve standards of patient care in the performance of robotic hepatectomies for colorectal metastases.
An automotive tire visual laser marking robot system based on multi-information fusion
Authors: Ren Chuanxiang , Xu Yunrui , Liu Xiang , Liu Haibo
Published: November 2024

As smart manufacturing technology continues to advance, laser marking robots have been applied to automotive tire marking, revolutionizing the traditional manual process. In order to improve productivity, these robots face challenges posed by tire positioning, environmental variations, and the light-absorbing properties of the material. In order to solve the problem, a robot vision modeling method based on the fusion of the 3D point cloud information and 2D image information on the surface of automotive tires is presented and is used to construct a visual laser marking robot system for automotive tires. The constructed visual laser marking robot system for automotive tires has been tested and the results show that the laser marking is more effective compared to the traditional manual marking process; the laser marking robot system equipped with a multi-information fusion vision model increases the marking success rate by 8%, increases the speed by nearly nine times, reduces the waste tire rate by 8%, and reduces the economic consumption by nearly 56 times; compared with a single vision information marking robot system, the marking success rate increases by 3% and the tire waste rate reduces by 3%.
The Effect of Visual Composition Created by Mosque Envelope in Generating Solemnity
Authors: Bayuaji Wisnu Hendrawan , Pramitasari Dewi , Ratnasari Zusnita
Published: November 2024

The architecture of the mosque building is one of the most developed building typologies in Indonesia, and it has a high variation of form. This study evaluates how the mosque envelope affects its primary function as a prayer hall. Religious worship that requires solemnity is influenced by a spiritual atmosphere where lighting is important. This study takes a deeper step by identifying the lighting configuration produced by the openings in the mosque envelope and evaluating its effect on solemnity. Illumination data, building physical information of envelope and openings, and calibrated photo documentation are collected from three Yogyakarta Mosque building cases representing vernacular, Middle Eastern, and contemporary styles. These data are analyzed according to light intensity, contrast ratio, light distribution, and visual acuity to identify how it affects the formation of a spiritual atmosphere through the generation of visual performance, such as concentration and ability to focus, mood, and comfort. Bright, high-contrast, dramatic, and colored light can undermine the potential for evoking solemnity, while dim, low-contrast, uniform, and natural intensity prevents distractive visual information from flowing into the brain, resulting in a less challenging effort to focus and concentrate. A uniform light generates more visual comfort compared to high contrast as it maintains less eye-adaptation. A serene, calm, dim, humble, and soothing ambient is considered relevant to the generation of solemnity as it promotes humility and assists the prayer to feel calm and relaxed. Further research is needed to reveal the optimal model of mosque shape and opening configuration that contributes positively to the generation of solemnity.
Connectivity and Integration of Trading Space: A Space Syntax Study of Pasar Tengah, Bandar Lampung
Authors: Mahendra Fasha Nurliansyah , Putra Hadi Jaya
Published: November 2024

Pasar Tengah in Bandar Lampung has evolved as a vibrant trading hub, developing spontaneously and organically over time. Due to the limited availability of land and the use of roads for both social and economic activities, understanding the spatial configuration of this area is crucial for analyzing movement patterns and activity distribution. This study investigates how the spatial configuration of Pasar Tengah influences the distribution and concentration of social and economic activities within the market. Connectivity and spatial integration are key factors shaping the strategic placement of commercial spaces. By employing space syntax analysis and reviewing relevant literature on market activities, the research identifies areas with dominant activity levels based on connectivity and integration metrics. The findings highlight key locations with high activity concentrations, though other factors must also be considered when selecting sites for commercial development.
LOCI THEOLOGICI EN TIEMPOS SINODALES: NOTAS SOBRE EPISTEMOLOGÍA TEOLÓGICA EN PERSPECTIVAS INTERCULTURALES
Authors: Eckholt Margit
Published: November 2024

El artículo recuerda la doctrina de los loci theologici de Melchor Cano y la abre para una epistemología teológica al servicio de la eclesiogénesis en tiempos de sinodalidad. En la edad moderna, Cano ha abierto caminos para una dogmática moderna al incluir la historia como locus alienus. En el presente, la doctrina de los loci theologici contribuye al desarrollo de una dialéctica tópica que da espacio a la iglesia local postconciliar y a los desarrollos teológicos contextuales. Abre el camino a una epistemología teológica de una iglesia mundial en la que los diferentes contextos culturales entran en un diálogo vivo en el discernimiento de la verdad teológica. Desde la perspectiva de una teóloga alemana, puede entonces ser posible identificar los elementos básicos de una forma de epistemología que sea consciente de la crítica a las figuras teológicas eurocéntricas del pensamiento del pasado y tenga en cuenta los desafíos decoloniales.
PALABRAS CLAVES: Melchor Cano. Loci theologi. Vaticano II. Interculturalidad. Sinodalidad.
A BUSCA POR UMA RACIONALIDADE DA GRAÇA: A ABORDAGEM DE PAUL TILLICH À MODERNIDADE E AO CAPITALISMO
Authors: Dumer Pablo Fernando
Published: November 2024

O artigo discute o pensamento de Paul Tillich, teólogo protestante teutoestadunidense, e sua abordagem a respeito dos problemas da modernidade e do capitalismo. A crítica de Tillich ao capitalismo é uma crítica à modernidade, isto é, de um tipo de racionalidade como uma forma de dessignificação da natureza, ou seja, sua objetificação, e, então, sua dominação. O teólogo compreende que essa forma de racionalidade é estruturante para o modelo econômico de exploração e, em decorrência, de suas consequências sociais e, podemos entender, também ambientais. Superar a crise atual, portanto, envolver repensar a relação do ser humano com a natureza e sua forma de pensá-la. Busca-se, assim, uma racionalidade teológica e religiosa capaz de abarcar a autonomia ao mesmo tempo em que se relacione com a natureza enquanto um significante. Leonardo Boff, pensador católico, chama esse processo de modo de pensar sacramental; Tillich de novo realismo (crente) e/ou teonomia. Chamamos, aqui, de racionalidade da graça, isto é, uma racionalidade a partir da relacionalidade no lugar da dominação. Esta racionalidade supera dicotomias a partir de um modo de conhecer, pensar e comunicar abrangente e reconciliador. Em síntese, o artigo objetiva demonstrar o desenvolvimento do tema no pensamento de Paul Tillich e discuti-lo com os desafios que se impõem do paradigma contemporâneo e as contribuições que a teologia e as ciências da religião podem oferecer à epistemologia geral da humanidade e do ecossistema.
PALAVRAS-CHAVE: Paul Tillich. Modernidade. Capitalismo. Natureza. Graça.
EL SILENCIO COMO DISTANCIA INAUGURADORA ANTE LA POSIBILIDAD DE LA IDOLATRIA. APORTES DESDE LA TEOLOGÍA
Authors: Agretti Dayse
Published: November 2024

El Dios cristiano es un Dios que se comunica y se revela a través de su Hijo Jesucristo, la Palabra hecha carne (Jn 1,14). En un mundo lleno de ruidos y distracciones atrayentes, el silencio es una condición fundamental como ejercicio constitutivo del acto teológico. Precedida por un silencio contemplativo e intelectual, la reflexión teológica tiene una tarea importante: hacer más inteligible al verdadero Dios cristiano ante otros dioses que se nos presentan en el camino. El silencio teológico posibilita una distancia que inaugura. Se trata de la necesaria distancia inauguradora que posibilita establecer una relación entre alteridades. Si una de las partes es absoluta, termina ocupando todo el espacio y, por tanto, se transforma en un ídolo. La idolatría no es un concepto petrificado ni cosa del pasado, es una tentación siempre latente. Es una falsificación conceptual y práctica del verdadero Dios. La dinámica idolátrica rechaza el silencio.
PALABRAS CLAVES: Silencio. Idolatría. Alteridad. Relacion.
THE DIFFERENTIATION OF SPIRITUAL AND PSYCHOLOGICAL COUNSELING AS AN EPISTEMOLOGICAL PROBLEM
Authors: Oželis Remigijus , Juškienė Vaineta
Published: November 2024

Epistemology, as a theory of knowledge, examines the problems of the nature, origin, structure, and limits of cognition and understanding. It can provide guidelines for individuals on how to establish a relationship with the external environment, find their place in it, or adapt to it. Within the framework of epistemology, we can look at spiritual counseling, whose priority also involves existential questions, the search for answers to issues such as life, suffering, death, love, transcendence, etc. Spiritual counselors are still searching for clear boundaries for their actions and practices. Although spiritual counseling is not equivalent to psychological counseling, in many cases, they are closely related. Common aspects can be found in both types of counseling. These connections are significant for achieving holistic spiritual assistance but often introduce epistemological confusion and difficulties in trying to differentiate these areas. In spiritual counseling, the aim is to approach the individual through the lens of religious belief. While practitioners in both spiritual and psychological counseling employ similar professional skills, it is important to recognize and distinguish the values guiding specialists in both practices. The article seeks to answer the question: what are the major differences and similarities between spiritual and psychological counselling? To justify the distinction and identity of spiritual and psychological counseling, this article seeks to reveal the essence, meaning, differences, and points of connection between these methods of assistance. Research methods: review, analysis, and synthesis of scientific literature and research.
KEY WORDS: Theology. Psychology. Spiritual counseling. Psychological counseling. Spiritual counselor.
Linguistic dynamics: women versus general population in Reddit ADHD discussions
Authors: Rahman Muhammad Mahbubur
Published: November 2024

Understanding how language reflects the experiences of individuals with attention-deficit/hyperactivity disorder (ADHD) is important for developing targeted support strategies. This research investigates the linguistic patterns exhibited in discussions within women-centric and general ADHD communities on Reddit, exploring how gender influences language use. By analyzing language, the study uncovers unique linguistic patterns and illustrates how posters on the women’s ADHD subreddit express themselves, share experiences, and seek support compared to posters on the general ADHD subreddit. Leveraging deep learning–based embeddings, clustering, and named entity recognition, the study conducts a comprehensive analysis. Results reveal that posters on the women’s ADHD subreddit emphasize themes such as “ADHD Awareness and Diagnosis” and “Emotional Well-being”. Conversely, posters on the general ADHD subreddit highlight “Medication and Treatment” and “Work and Academic Challenges”. Statistical tests confirm significant differences in both linguistic and emotional expressions between the two groups, emphasizing the importance of gender considerations in understanding ADHD language nuances and tailoring interventions accordingly.
A Comparison of Laminectomy and Hemilaminectomy Approaches for Resection of Spinal Schwannomas and Meningiomas
Authors: Aiudi Denis , Lisi Serena Vittoria , Cappella Fabiola , Di Rienzo Alessandro , Iacoangeli Alessio , Gladi Maurizio , Mattioli Andrea , Dobran Mauro
Published: December 2024

Background: Spinal schwannomas and meningiomas represent common benign tumors of the spinal cord in adults, necessitating total excision. While total laminectomy has conventionally been employed, unilateral hemilaminectomy has emerged as a viable alternative. Methods: A retrospective analysis was conducted on patients undergoing spinal meningioma or schwannoma resection via laminectomy or unilateral hemilaminectomy from January 2013 to January 2023. Patient demographics, operative techniques, and postoperative outcomes were compared. Results: The study comprised 41 patients (mean age: 62.5 ±14.6 years), with 59% schwannomas and 41% meningiomas, predominantly in the thoracic spine. Total excision was achieved in all cases. Schwannoma resections had longer operative times (p=0.001) and greater intraoperative blood loss (p=0.000) compared to meningiomas. Unilateral hemilaminectomy (41%) exhibited ad-vantages over total laminectomy (59%), including reduced postoperative bed rest (p=0.003), shorter hospital stays (p=0.028), and diminished postoperative pain (p=0.02). Conclusions: Uni-lateral hemilaminectomy is a safe and effective approach for spinal schwannomas and menin-giomas of various sizes. It offers superior outcomes compared to total laminectomy, with benefits such as decreased postoperative bed rest, shorter hospitalization, and lower postoperative pain.
Self-Organizing Systems: What, How, and Why?
Authors: Gershenson Carlos
Published: December 2024

I present a personal account of self-organizing systems. As such, it is necessarily biased and partial. Nevertheless, it should contain enough substance to motivate useful discussions. The relevant contribution is not my attempts at answering questions (maybe all my answers are wrong), but the steps towards framing relevant questions to better understand self-organization, information, complexity, and emergence. With this aim, I start with a notion and examples of self-organizing systems (what?), continue with their properties and related concepts (how?), and close with applications (why?) in physics, chemistry, biology, collective behavior, ecology, communication networks, robotics, artificial intelligence, linguistics, social science, urbanism, philosophy, and engineering.
Titanium Dioxide and Photocatalysis: a Detailed Overview of the Synthesis, Applications, Challenges, Advances and Prospects for Sustainable Development
Authors: Nematov Dilshod , Ashurov Anushervon , Umarzoda Mufazzala
Published: December 2024

The term “photocatalysis” has recently gained high popularity, and various products using photocatalytic functions have been commercialized. Of all the materials that may be used as photocatalysts, titanium dioxide (TiO2) is virtually the only one that is now and most likely will remain appropriate for industrial application. Water and air purification systems, sterilization, hydrogen evolution, self-cleaning surfaces, and photoelectrochemical conversion are just a few of the products and applications in the environmental and energy domains that make extensive use of TiO2 photocatalysis. This is due to the fact that TiO2 has the lowest cost, most stability, and most effective photoactivity. Furthermore, history attests to its safety for both people and the environment because it has been used as a white pigment since antiquity. This review discusses some important aspects and issues concerning different synthesis methods and their influence on the structure and properties of TiO2, as well as the concept of photocatalysis based on it as a promising biocompatible functional material that has been widely used in recent years. The advantages of TiO2 applications in various fields of science and technology are discussed, including environmental protection, photocatalysis including self-cleaning surfaces, water and air purification systems, hydrogen liberation, photovoltaic energy, cancer diagnosis and therapy, coatings and dental products, etc. Information on the structure and properties of TiO2 phases is presented, as well as modern methods of synthesizing functional materials based on it. A detailed review of the basic principles of TiO2 photocatalysis is then given, with a brief introduction to the modern concept of TiO2 photocatalysis. Recent advances in the fundamental understanding of TiO2 photocatalysis at the atomic-molecular level are highlighted, and advances in TiO2 photocatalysis from the perspective of design and engineering of new materials are discussed. The challenges and prospects of TiO2 photocatalysis are briefly discussed.
The Influence of the Substrate and of Environmental Conditions on the Performance of Lime-Based Mortars: Paimogo Fort, a Case Study
Authors: Santos Ana Rita , Veiga Rosário , Santos Silva António
Published: December 2024

In order to revitalize and preserve the Paimogo Fort, a Portuguese coastline military fortification built in 1674 and classified of public interest since 1957, several lime-based repair rendering mortars were developed, considering the compatibility requirements with the pre-existing ones. In this investigation the different lime-based mortars compositions proposed are briefly described and their main physical and mechanical characteristics are analysed in successive ages (28, 90 and 180 days). Furthermore, some applications of the same mortars’ compositions on different porous substrates were carried out and their performances were compared in laboratory and in situ conditions. Finally, the possible degradation mechanism and the impact of the composition, interaction with the substrate and climatic and environmental conditions on the durability of the mortars are discussed. The main outcomes show that mortars with some content of quicklime conduct to a balanced solution for the restoration work of the Fort; however, when applied on very absorbent substrates, this type of compositions can lead to a decrease of adhesion between the mortar and the substrate.
Drainage Congestion and Its Impacts on Urban Environment: An Impact Assessment on Chattogram Metropolitan City, Bangladesh
Authors: Al Mahbub Hossain , Sarwar Md. Iqbal , Muhibbullah Muhammad , Ahmed Rashed
Published: December 2024

Inadequate urban storm water drainage problems represent one of the most common sources of complaint from the citizens in many cities of Bangladesh and this problem is getting worse and worse with the ongoing high rate of urbanization. Drainage congestion has already been treated as a major urban environmental problem for Chattogram as well as in Bangladesh. It has become a major issue in the port city Chattogram in recent year. A few hours’ monsoon rain makes the overflow of water from the drains of Chattogram city. Rather it creates vulnerability and play a significant impact on the urban environment, economic environment, ecology, human habitat and so on. This study investigates the impacts of drainage congestion on the urban environment in Chattogram city, Bangladesh. Primary data have been collected through 200 questionnaires administered to residents of the study area, and 4 FGDs have been conducted to validate and cross-check the data obtained from the questionnaires. The secondary data have been collected from various sources like books, journals, magazines, CDA, CCC, CWASA reports, etc. The results of this study show that the dominant causes of urban drainage congestion are: lack of drainage, population growth, encroachment into natural drainage, excessive rainfall, unplanned urbanization, blockages of drains by solid waste, absence of dredging system, etc. This drainage congestion is a problem creating adverse social, physical, economic, and environmental impacts on the life and living in Chittagong. Disruption of transport and communication systems; drainage death trap, damage to infrastructure; destruction of vegetation and aquatic habitats; and loss of income potentials are the effects of drainage congestion on city life. The aggregate outcome of this research suggests that Chittagong will face rigorous environmental problems if this trend of urban drainage congestion continues. The aggregate outcome of this research suggests that solid waste management, regular dredging, raising awareness of the residents and close coordination among urban authorities and collaboration between public and private sectors are needed for sustainable operation of the drainage system to minimize urban drainage congestion in Chittagong.
Assessment of 3-Cyanobenzoic Acid as a Possible Herbicide Candidate: Effects on Maize Growth and Photosynthesis
Authors: Grizza Luiz Henryque Escher , Contesoto Isabela de Carvalho , Mendonça Ana Paula da Silva , Comar Amanda Castro , Boromelo Ana Paula , Ferro Ana Paula , Constantin Rodrigo Polimeni , dos Santos Wanderley Dantas , Marchiosi Rogerio , Ferrarese-Filho Osvaldo
Published: December 2024

Chemical weed control is a significant agricultural concern, and reliance on a limited range of herbicide action modes has increased resistant weed species, many of which use C4 metabolism. As a result, the identification of novel herbicidal agents with low toxicity targeting C4 plants becomes imperative. An assessment was conducted on the impact of 3-cyanobenzoic acid on the growth and photosynthetic processes of maize (Zea mays), a representative C4 plant, cultivated hydroponically over 14 days. The results showed a significant reduction in plant growth and notable disruptions in gas exchange and chlorophyll a fluorescence due to the application of 3-cyanobenzoic acid, indicating compromised photosynthetic activity. Parameters such as the chlorophyll index, net assimilation (A), stomatal conductance (gs), intercellular CO2 concentration (Ci), maximum effective photochemical efficiency (Fv'/Fm'), photochemical quenching coefficient (qP), quantum yield of photosystem II photochemistry (ϕPSII), and electron transport rate through PSII (ETR) all decreased. The A/PAR curve revealed reductions in the maximum net assimilation rate (Amax) and apparent quantum yield (ϕ), alongside an increased light-compensation point (LCP). Moreover, 3-cyanobenzoic acid significantly decreased the carboxylation rates of RuBisCo (Vcmax) and PEPCase (Vpmax), electron transport rate (J), and mesophilic conductance (gm). Overall, 3-cyanobenzoic acid induced substantial changes in plant growth, carboxylative processes and photochemical activities. The treated plants also exhibited heightened susceptibility to intense light conditions, indicating a significant and potentially adverse impact on their physiological functions. These findings suggest that 3-cyanobenzoic acid or its analogs could be promising for future research targeting photosynthesis.
Can Hyperacusis Be Improved?
Authors: Konstantinou Antonia , Eleftheriadis Nikos , Moschopoulos Nikolaos , Sidiras Christos , Iliadou Vassiliki Maria
Published: December 2024

Hyperacusis, a symptom related to hypersensitivity to sounds, has an estimated prevalence of 9%-15% and leads to impaired social, emotional and attentional functioning. This study explores an intervention method to minimize hyperacusis. ). The aim of our study was to answer the fol-lowing research questions, whether hyperacusis can be improved through systematic guided ex-posure to annoying sounds under experimental controlled conditions and whether temporal reso-lution can be improved with auditory training. Methods included an initial interview, Khalfa Hyperacusis questionnaire, guided exposure to annoying sounds, temporal resolution pre and post auditory training evaluation. The sample was composed of 33 adults that where spilt into an ex-perimental hyperacusis group and a control one based on their score at Kalfa's Hyperacusis ques-tionnaire (cut off 16). It was found that the experimental group ameliorated its hyperacusis dis-comfort (p=0.001) as well as improved its temporal resolution for both right (p=0.001) and left ears (p=0.003). Individuals with hyperacusis can benefit from auditory training both in terms of symptomatology and temporal resolution.
Crosstalk Between Abiotic and Biotic Stresses Responses and the Role of Chloroplast Retrograde Signaling in the Cross-Tolerance Phenomena in Plants
Authors: Kamran Muhammad , Burdiak Pawel , Karpiński Stanisław
Published: December 2024

In natural environment plants are simultaneously exposed to multivariable abiotic and biotic stresses. Typical abiotic stresses are changes in temperature, light intensity and quality, water stress (drought, flood), microelements availability, salinity, air pollutants and others. Biotic stresses are caused by other organisms such as pathogenic bacteria and viruses, or by parasitic insects and plants. This review presents the state of the art of the programmed cell death in the cross-tolerance phenomena and its conditional molecular and physiological regulators, which are involved in simultaneous regulation of plant acclimation, defense and developmental responses. It highlights the role of the absorbed energy in excess and its dissipation as heat in induction of the chloroplast-retrograde electrical, phytohormonal, reactive oxygen species signaling and heat shock related pathways in connection to activation of the molecular regulators of plant growth, yield and cell wall development. It also discusses how systemic and network-acquired acclimation and acquired systemic resistance are mutually regulated and demonstrates the role of non-photochemical quenching and the dissipation of absorbed energy in excess as heat in the cross-tolerance phenomenon. Finally new evidences that in plants evolved one molecular system to regulate cell death, acclimatization and cross-tolerance to abiotic and biotic stress are presented and discussed.
Exploring the Plasma Membrane Lipid Interactions and Properties in Experimental Models
Authors: Oliveira Igor S. , Pinheiro Guilherme X. , Sa Maria Luana B. , Gurgel Pedro Henrique L.O. , Pizzol Samuel U. , Itri Rosangela , Henriques Vera B. , Enoki Thais A.
Published: December 2024

This mini review intends to highlight the importance of bilayer asymmetry. Biological membranes are complex structures that are a physical barrier separating the external environment from the cellular content. This complex bilayer comprises an extensive lipid repertory, suggesting that the different lipid structures might subserve a role in the membrane. Interestingly, this vast repertory of lipids is asymmetrically distributed between leaflets that form the lipid bilayer. Here, we discuss the properties of the plasma membrane under the view of experimental model membranes, consisting in simplified and controlled in vitro systems. We summarize some crucial features of the exoplasmic (outer) and cytoplasmic (inner) leaflets observed through investigations using symmetric and asymmetric membranes. Symmetric model membranes for the exoplasmic leaflet have a unique lipid composition that might form a coexistence of phases, namely liquid disordered and liquid order phases. These phase domains may appear in different sizes and shapes depending on lipid composition and lipid-lipid interactions. In contrast, symmetric model membranes for the cytoplasmic leaflet form a fluid phase. We discuss the outcomes reported in the literature for asymmetric bilayers, which vary according to lipid compositions and, consequently, reflect to different intra- and inter-leaflet interactions. Interestingly, the asymmetric bilayer could show induced domains in the inner leaflet, or it could decrease the tendency of the outer leaflet to phase separation. If cells regulate the lipid composition of the plasma membrane, they can adjust the existence and sizes of the domains by tuning the lipid composition.
Climate Metrics for Cultural Heritage: Modelling Conditions for Pilgrimage in Ethiopia
Authors: Richards Jenny , Brimblecombe Peter
Published: December 2024

Climate and weather influences human actions, including our cultural practices. Even though the effects of climate change on intangible heritage have been widely discussed there has been little work that links specific drivers of environmental change to impacts or effects. This study develops and tests a set of climate metrics relevant for pilgrimages, focusing its analysis on Ethiopia. Our study assesses the sensitivity of climate metrics to the time period studied using observed data (ERA5 reanalysis and CHIRPS) and the ability of three GCMs (HadGEM3-GC31-MM, CMCC-ESM2 and NorESM2-MM) to capture climate metrics relevant to pilgrimages within the dry season (Bega). Results show the importance of adjusting the length of time so it is relevant to the process or social practice being studied, which might not map onto the three-month seasons traditionally used in climate research. Three of the six climate metrics assessed (minimum and maximum daily temperature and the number of rain days greater 1 mm) were successfully captured by the GCMs. This means these metrics could be used to assess future impacts of climate change on the climate experienced by pilgrims in Ethiopia.
Immune-Boosting and Antiviral Effects of Antioxidants in COVID-19 Pneumonia: A Therapeutic Perspective
Authors: Sanduzzi Zamparelli Stefano , Sanduzzi Zamparelli Alessandro , Bocchino Marialuisa
Published: December 2024

The COVID-19 pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has profoundly impacted global health, with pneumonia emerging as a major complication in severe cases. The pathogenesis of COVID-19 is marked by the overproduction of reactive oxygen species (ROS) and an excessive inflammatory response, resulting in oxidative stress and significant tissue damage, particularly in the respiratory system. Antioxidants have garnered considerable attention for their potential role in managing COVID-19 pneumonia by mitigating oxidative stress and modulating immune responses. This review provides a comprehensive overview of the literature on the use of antioxidants in COVID-19 pneumonia and incorporates insights from our experience with Taurisolo®. Studies exploring antioxidants such as vitamin C, vitamin E, nitric oxide (NO), ozone (O3), N-acetylcysteine (NAC), and various polyphenols have demonstrated promising outcomes. These include reductions in inflammation and oxidative damage, as well as improvements in clinical outcomes. Through their ROS-scavenging properties, these molecules support endothelial function, reduce thrombosis risk, and may help mitigate the effects of the cytokine storm, a key contributor to COVID-19 morbidity and mortality. Clinical evidence suggests that antioxidant supplementation may improve patient outcomes by decreasing inflammation, supporting immune cell function, and potentially shortening recovery times.
Moreover, antioxidants may work synergistically with standard antiviral treatments to reduce viral-induced oxidative damage. By integrating findings from the literature with real-world data from our clinical experience, we gain a more profound understanding of the role of antioxidants in managing COVID-19 pneumonia. Further research combining comprehensive literature reviews with real-world data analysis is crucial to validate the efficacy of antioxidants and establish evidence-based guidelines for their use in clinical practice.
A Novel Bio-Inspired Bird Flocking Node Scheduling Algorithm for Dependable Safety-Critical Wireless Sensor Network Systems
Authors: Al-Nader Issam , Raheem Rand , Lasebae Aboubaker
Published: December 2024

The Multi-Objective Optimization Problem (MOOP) in Wireless Sensor Networks (WSNs) focuses on optimizing three key objectives: coverage, connectivity, and network lifetime. The MOO problem can be explored using the collective behaviour of the bio-inspired bird flocking model that preserves energy over long migration journeys. Applying such models in WSNs can help achieve the optimisation of the multiple core objectives: coverage, connectivity, and network lifetime. The bird flocking model works collaboratively with Lyapunov function to stabilize the three core objectives mentioned above to solve the MOOP in WSNs. The proposed novel multi-objective bio-inspired bird algorithm is implemented in a MATLAB simulation environment. The achieved results of the novel proposed bio-inspired bird algorithm are evaluated against our previous published work the bio-inspired bat algorithm where the former recorded an enhancement over the latter in many aspects; coverage 8%, connectivity 10%, and network lifetime 80%.
Natural Protein Films from Textile Wastes for Wound Healing and Wound Dressing Applications
Authors: Ottaviano Livia , Buoso Sara , Zamboni Roberto , Sotgiu Giovanna , Posati Tamara
Published: December 2024

In recent years, several studies have focused their attention on the preparation of sustainable biocompatible and biodegradable films of potential interest in wound healing and wound dressing applications. In this regard, natural macromolecules—such as proteins—represent an attractive alternative to synthetic polymers thanks to their numerous advantages, such as biocompatibility, biodegradability, and low immunogenicity. Among the most interesting proteins, keratin extracted from waste wool and fibroin extracted from Bombyx mori cocoons, possess all of the abovementioned features required for biomedical applications. In the present review, we therefore aim to give an overview of the keratin and fibroin based films designed for wound healing and wound dressing applications and devices.
Revealing the Environmental Footprint of Crepe Rubber Production: A Comprehensive Life Cycle Assessment of a Crepe Rubber Factory in Sri Lanka
Authors: Dunuwila Pasan , Munasinghe Enoka , Rodrigo V.H.L. , Gong Wenjing , Daigo Ichiro , Goto Naohiro
Published: December 2024

Natural rubber, a renewable material with unique properties, is crucial for various products on the modern market. Crepe rubber, a versatile form of natural rubber, is widely used in numerous applications, including footwear soles, medical devices, automotive parts, adhesives, sports equipment, industrial components, musical instruments, and recreational products. Sri Lanka holds a prominent position as a leading producer of premium-quality crepe rubber but faces environmental challenges in its production process. Since previous life cycle assessments (LCA) in the rubber industry are inadequate to capture overall environmental impact, the present study attempted to address the gaps by conducting a detailed LCA of a Sri Lankan crepe rubber factory, incorporating a novel index termed Trade-off valuation index (TOVI). The research revealed that fertilizer, water, and electricity use contribute most significantly to crepe rubber production's environmental impact. To mitigate these impacts, four key improvement options were identified and evaluated through scenario analysis: 1) enhancing fertilizer efficiency, 2) repairing leaky joints and valves, 3) implementing a water reuse system, and 4) installing solar panels. The integration of TOVI allowed for the prioritization of these options, providing actionable insights for industry stakeholders. This study paves the way for targeted interventions to enhance the sustainability of the natural rubber industry by balancing economic viability with environmental stewardship.
Extracellular Vesicles (EV) Derived from Mesenchymal Stem Cells (MSC) as Adjuvants in the Treatment of Chronic Kidney Disease (CKD)
Authors: Noda Paloma , Francini Ana LR , Teles Flavio , Junior Samuel J , Fonseca Fernando LA , Borges Fernanda T , Sobrinho Adão C , Taniwaki Noemi , Noronha Irene L , Fanelli Camilla
Published: December 2024

Chronic kidney disease (CKD) is considered an important health issue worldwide. The ren-in-angiotensin-aldosterone system (RAAS) blockade through the administration of angiotensin II receptor blockers, such as Losartan (LOS), have been considered the best strategy for CKD treatment for decades. However, this approach promotes only partial detention of CKD pro-gression and cannot reverse renal damage. The aim of the present study was to investigate whether the therapeutic administration of extracellular vesicles (EV) derived from adipose stem cells (ASC), associated to LOS treatment, would promote additional renoprotection in rats underwent the 5/6 renal ablation CKD model. ASC-derived EV were administered locally, in the renal subcapsular area, 15 days after CKD induction, when LOS therapy also began. Animals were followed for additional 15 days and our results demonstrated that subcapsular injection of ASC-derived EV associated with LOS, significantly reduced glomerulosclerosis, renal interstitial infiltration by myofibroblasts and macrophages in the 5/6 CKD model. Additionally, LOS+EV abrogated sys-temic hypertension, proteinuria and albuminuria, and stimulated local overexpression of the endogenous anti-inflammatory IL-4. Although more studies are still required to establish the best EV dose and administration route, these findings point to therapy with ASC-derived EV as a po-tential adjuvant in CKD treatment.
Peanut Allergy Diagnosis: Current Practices, Emerging Technologies and Future Directions
Authors: Satnarine Travis , Makkoukdji Nadia , Pundit Valishti , Vignau Alexia , Sharma Pranav , Warren Duenna , Kleiner Gary , Gans Melissa
Published: December 2024

Peanut allergy presents a significant and growing public health concern, marked by its increasing prevalence and potential for severe allergic reactions. Traditional diagnostic methods, such as skin prick testing and serum IgE assays, serve as cornerstone approaches but often fall short in specificity, sensitivity, and risk stratification. This has driven the development of innovative diagnostic technologies, including component-resolved diagnostics, basophil activation tests, bead-based epitope assays, molecular diagnostics, and artificial intelligence applications. These advancements promise greater diagnostic precision, improved patient stratification, and tailored management strategies. However, challenges such as high costs, accessibility issues, and the need for standardized protocols hinder their widespread clinical adoption. This review explores the evolution of peanut allergy diagnostics, comparing traditional and emerging methodologies, and discusses their clinical implications, limitations, and future directions. The integration of advanced technologies with established approaches holds the potential to revolutionize peanut allergy diagnosis and management, ultimately enhancing patient care and outcomes.