bluuebunny/crossref_metadata_2025 huggingface dataset:
Pediatric Modification For Alvarado Score: Appearance Of Patients With Apandisitis
Authors: Beger Burhan , Etgul Cihan , Şimşek Metin , Sönmez Bülent , Ulusoy Tangül Sevgi
Published: July 2024

ABSTRACT
Objective: This study, with the purpose of decreasing the morbidity rate in emergency pediatric surgery clinics, evaluates the reliability of an acute appendicitis diagnosis score we define as “appearance of the patient with appendicitis (APA)”, which is a new modification of Alvarado Score (AS).

Methods: One hundred eighty patients, that admitted to Van Training and Research Hospital between February 2018 and June 2018 and were consulted to pediatric surgery with acute appendicitis suspicion; were analyzed as a randomized prospective study. In the new scoring system which we define as APA, instead of a left shift of neutrophils – a state of the patients lying still in the bed, reluctant to speak, with dry lips, with tired eyes, upset and with a troubled expression at the face is placed. For all the patients, AS (AS 1-4, AS 5-6 and AS 7-10) and APA (APA 1-4, APA 5-6 and APA 7-10) scores were independently calculated as three groups and were compared to each other.

Results: 180 children (108 males – 72 female) with an average age of 11 (range, 6 – 15) were included in the study. Distribution of patients in the three groups of AS was determined as 1-4: 90 (50%), AS 5-7: 48 (26.7%) and AS 8-10: 42 (23.3%) respectively. Distribution of patients with respect to APA score were as APA 1-4: 72 (40%), APA 5-7: 69 (38.3%) and APA 8-10: 39 (21.7%). Appendectomy was performed on 3 patients from the AS 1-4 group, on 15 patients from AS 5-6 group and on 33 patients from AS 7-10 group. Whereas none of the patients from the APA 1-4 group had an appendectomy, 18 patients from APA 5-6 group and 33 patients from APA 7-10 group had an appendectomy.

Conclusion: By means of the APA which we define as a combination of AS and clinical judgment (CJ), the number of pediatric cases with appendicitis suspicion to be kept under observation was increased and unnecessary –too early or too late- surgical intervention incidence was decreased. Our study shows CJ and scoring systems are not alternative methods for each other and collective use of both can decrease morbidity and mortality in acute appendicitis treatment.
You ‘again’: an acquisition study on its restitutive reading with goal-PPs
Authors: Xu Ting , Snyder William , Christie Stella
Published: July 2024

Availability of restitutive ‘again’ varies both cross-linguistically and language-internally. This creates an acquisition puzzle: For each change-of-state predicate, how do children know if a restitutive reading is possible? In child-directed English, unambiguously restitutive uses of ‘again’ with a “goal-PP” structure (e.g., ‘walk to the village’) are exceedingly rare. Nonetheless, comprehension tasks with goal-PPs show that preschoolers already know the reading is available. Here we show that the same pattern holds for Mandarin you (roughly, ‘again’): extremely little direct, unambiguous evidence for the restitutive reading with goal-PPs, but preschoolers already know it is possible. This pattern is all the more remarkable for Mandarin because you is both preverbal and polysemous, making it less transparent how the restitutive reading is obtained. We propose that our findings fit neatly in a structural approach, where restitutive readings involve attaching ‘again’ to a VP-internal result phrase: The child can deduce the availability of restitutive you if they have acquired both the property allowing repetition-denoting you to semantically compose with a sub-constituent of the VP, and the structural properties of Mandarin goal-PPs that make a restitutive reading possible.
Estimating the cost-effectiveness of several reservoir evaporation suppression strategies: a case study
Authors: RA Chapman  , D Svendsen  , J de Waal
Published: July 2024

Reservoirs often experience significant evaporation, causing a reduction in productive water use and prompting calls to curtail the loss. While efforts to reduce evaporation have predominantly focused on improving efficiencies, there has been a comparatively limited exploration of the associated costs per unit of additional water yield. To address this, a unit reference value (URV) calculation approach was employed in a case study to compare the unit costs of this additional yield through various evaporation suppression methods. The evaluated techniques included chemical monolayers, shade cloth, and both hard and soft floating covers. The URV calculation factored in capital, operating, and maintenance costs over a 20-year term, specified water-saving efficiencies for each technology, and various environmentally driven evaporation and social discount rates. The resulting URVs were compared with those for raising the Clanwilliam Dam, a large-scale groundwater scheme and the URVs for desalination. Notably, monolayers emerged with the lowest URV, but their yield efficiency is severely compromised by their short lifespan and high susceptibility to wind. The URVs of shade cloth proved competitive with those of desalination but are practical only for relatively small areas. In contrast, floating hard and soft covers demonstrated higher per-unit water delivery costs than desalination due to more frequent capital equipment replacements caused by their faster wear and weathering. The findings suggest that current evaporation suppression technologies may be economically unfeasible for agricultural and even domestic water supplies. The URV calculation serves as a valuable tool for comparing the cost-effectiveness of diverse yield-additive strategies.
Rischio aritmico ventricolare in cardio-oncologia: un caso clinico
Authors: Carbone Vincenzo
Published: July 2024

Numerosi farmaci antitumorali possono indurre un prolungamento dell’intervallo QTc, così da provocare un aumentato rischio di aritmie ventricolari potenzialmente fatali, come la Torsione di Punte (TdP), soprattutto in presenza di fattori di rischio concomitanti. Alcune alterazioni elettrocardiografiche (ECG), al di là del semplice reperto di un intervallo QTc lungo, sono considerate segnali di pericolo in grado di predire un’aumentata suscettibilità alla TdP farmaco-indotta. Tra queste, un intervallo QTc molto lungo (≥ 500 ms) con ulteriore prolungamento pausa-dipendente, un’esagerazione e deformazione post-pausa delle onde T, extrasistoli ventricolari elicitate da lunghi cicli R-R e distribuite in ritmo bigemino (la cosiddetta “regola del bigeminismo”, espressione di attività triggerata indotta da postdepolarizzazioni precoci) rappresentano i più forti predittori ECG di TdP nel contesto del prolungamento farmacoindotto dell’intervallo QTc. Questo caso clinico enfatizza il ruolo prognostico dell’ECG nello scenario di cui sopra.
Phytochemical Study, Antioxidant Activity and GC-MS Analysis of Soymida febrifuga A. Juss
Authors: Sinalkar Smita ,   Department of Biotechnology, Changu Kana Thakur College of Arts, Commerce and Science, (Autonomus), New Panvel, Maharashtra, India, Kokitkar Seema
Published: July 2024

Objectives: To determine antioxidant activity and identify bioactive compounds present in n-Hexane & Ethyl acetate extracts of stem bark of Soymida febrifuga A. Juss. Methods: In the present study stem bark of Soymida febrifuga A. Juss was powdered and subjected to Soxhlet extraction using n-Hexane and Ethyl acetate as solvents. Extracts were analysed for the presence of phytochemicals and antioxidant activity. The Bio-active compounds were identified by Gas chromatography-mass spectrometry. Findings: The qualitative analysis revealed presence of various phytochemicals. GC-MS analysis confirmed the presence of total 28 Medicinally active compounds which included Tetradecane, Hentriacontane, Octacosane, Docosane and Eicosane in n-Hexane extract. 15 Medicinally active compounds were found in ethyl acetate extract which included Purolan, 1,2-Dipropenyl cyclobutane, Hentricontane, 2,6,7-Trimethyl decane, Tetrahydrofurfuryl propionate and Decyl propanoate. Novelty: Though the phytochemical analysis of Soymida febrifuga have been performed by some research groups but there are no reports on identification of Bio-active compounds by GC-MS. The results obtained from present study confirms presence of many compounds of biological significance that warrants further biological and pharmacological study of Soymida febrifuga A. Juss as a potential herbal drug. Keywords: Soymida febrifuga; GC-MS analysis; DPPH assay; n-Hexane; Ethyl acetate
Thermal Image Based Occupant Count Measurement Model using Human Body Temperature for Smart Building
Authors: Lavanya R ,   Department of Information Technology, Aalim Muhammed Salegh College of Engineering, Chennai, 600 055, Tamil Nadu, India, Shanker N R
Published: July 2024

Objectives: The proposed Occupant Count Measurement (OCM) model aims to enhance sustainability, energy efficiency, comfort, and safety in smart buildings by accurately determining occupant count using thermal camera images and body temperature data. Methods: The model leverages real-time thermal camera images without the need for a pre-existing dataset. Key parameters include temperature threshold, occupant motion, size, and shape to ensure accurate occupancy estimation. The K-means algorithm identifies and clusters regions of interest (ROI) in thermal images corresponding to human body temperatures. The model also employs sensors like PIR, RGB cameras, and thermal image sensors. Manual counting serves as a benchmark for comparison. Findings: The K-means algorithm extracts regions with elevated temperatures related to human bodies from thermal images, partitioning them into K-clusters based on temperature ranges and assigning each pixel to one of the clusters. A temperature threshold differentiates human clusters in the thermal image, while connected component labeling refines human object segmentation by identifying blobs, which are then used for occupant counting. The model's precision is assessed using diverse image sensors and compared to the actual number of occupants. The proposed OCM model achieves an accuracy of about 90.2% compared to traditional methods. Novelty: This study introduces an OCM model that uses thermal images to estimate the number of occupants in a room based on their body temperature. The method focuses on detecting and counting occupants by their overall thermal body signature, providing a novel approach to occupant measurement in smart buildings. Keywords: Thermal Images, Segmentation, Occupant Estimation, Occupant Comfort, Smart Building
Issues of Improving Expense Tracking and Calculating Prime Cost in Agriculture
Authors: Ibragimov Abdugapur Karimovich ,   Department of Accounting and Audit, The Banking and Finance Academy of the Republic of Uzbekistan, Ulugbek district, Tashkent, Uzbekistan, Gulchiroy Tursunkulova , Pansera Bruno Antonio
Published: July 2024

Objectives : This article is devoted to the consideration of the issues of cost accounting and cost calculation in agriculture. In addition, the article highlights the issues of the correct distribution of costs by cost items and objects, as well as the correct calculation of the cost of Uzbekistan's products. In addition, Uzbekistan is an agrarian country, so the article presents suggestions and recommendations for improving the accounting of costs and production costs in agriculture. Previous studies in this area conducted in other parts of the world indicate a direct relationship between the indicators of production costs and market indicators; however, based on the features of Uzbekistan, it may be different, given the accounting policy and the specifics of agricultural costs. Methods: A linear regression method to determine the impact of costs and methods of calculating the cost of production was used. Costs are divided into variables and constants. Based on the features of agriculture, simple, advanced, and regulatory methods are used. Each of these methods is associated with variables and regresses individually for each type of agricultural product. Findings: Our results confirm that there are some methods of calculating the cost of production of farms. The results also indicate that the correct determination of the cost of production affects the profitability of these farms. The results obtained indicate that the calculation of the cost of agriculture is an indicator of the profitability of farms in Uzbekistan in the short term. The impact of the change in the cost of agricultural products influences profitability, in the end on profit; as it influences the prices of sales of products in the end affect the financial performance of farms. Novelty: The impact of the cost of agricultural products on the profitability of farms is becoming more important than ever before since the negative externalities of cost changes affect the financial performance of farms. Keywords: Farms, Expenses, Cost, Product cost, Accounting register
Time Series Analysis for Air Pollution Prediction in High-Intensity Development Areas using Deep Learning
Authors: Sasikanth K V K ,   Research Scholar, JNTUK, Kakinada, Sujatha B , Haritha D
Published: July 2024

Objective: The purpose of this study is to design novel approach to predict air pollution indices accurately using hybrid approach in highly populated cities of the world. Methods: This study aimed to address the significant bottleneck of relying on a single model for time series analysis which we accomplished by developing a hybrid forecasting method. This blended method combines the advantages of CNN (Convolutional Neural Networks) and LSTM (Long Short Term Memory) hybrid model together, overcoming insufficiency of air pollution prediction. Findings: Due to the empirical operation that revealed in achieving proper predictions we have come to understand that relying on a single model for the estimation of time-series data results is inefficient and misleading, mostly due to the non-linear nature of raw data. On the other hand, by using this hybrid model forecasting, we can uncover more detailed patterns through longer period of time and predict them more accurate by using weather and air pollution related data.The hybrid CNN-LSTM Model achieved least values of 6.742 for MAE,12.921 for RMSE compared to other approaches, which indicatesmere perfection. Novelty: The novelty of our approach is to fuse LSTM and CNN models in order to perform exhaustive analysis on the dynamics of the air pollution throughout the entirety of the city. Through the combination of these two models, such a tool is made simpler to use, and there is an improved accuracy in predictions. This thus becomes a promising tool in the fight against air pollution in cities that have a very high population just like Delhi. Keywords: ­ Air Pollution, LSTM, CNN, Deep Learning, Time Series Analysis, Nonlinear Relationships
Finite MX/M/C Queue with State Dependent Service, Two-Class Arrivals and Impatient Customers
Authors: Varma P Mahendra ,   Research Scholar, Department of Engineering Mathematics, College of Engineering, Koneru Lakshmaiah Education Foundation, Vaddeswaram, 522302, Andhra Pradesh, India, Kottapalli Rajyalakshmi , Devi V N Rama
Published: July 2024

Objectives: 1. To compute the transition probabilities for the queueing system to be in different states. 2. To calculate the average system length and mean waiting time under the specified parameters. 3. To investigate and test the impact of system characteristics on the anticipated system length as well as mean waiting times. Method: MATLAB software is used for the Runge-Kutta method to calculate probabilities and system constants. Findings: An increase in Type-I arrival rate λ1 and Type-II arrival rate λ2 will cause both mean waiting times and queue length to increase, and they are reduced with an increase in service rates µ1 and µ2 of Type-I and Type-II classes. A rise in parameters such as special service rate µ3, probability of balking and reneging will result in a reduction in both mean waiting times and queue length. Novelty: This article covers a batch arrival finite Markovian queueing system with multi-server support and consumer impatience. In real time, all arrivals need not enter the queue at the same arrival rates, as it is based on the needs of the customer. In view of this, we have assumed two types of customers along with two different rates of arrival and state-dependent service. We did our work in transient mode, as time can influence the waiting lines. Also determined the system's performance indices and demonstrated the impact of the input parameters on the system's constants. Keywords: Batch Arrival, Customer Impatience, Two Class Customers, State Dependent Service, Multi Server Facility
A Portrayal of Integer Solutions to Transcendental Equation with Six Unknowns 𝟑√ 𝐗 + 𝐘 + √ 𝐱𝐲 = 𝑧𝟐 + 𝑤𝟐
Authors: Thiruniraiselvi N ,   Assistant Professor, Department of Mathematics, School of Engineering and Technology, Dhanalakshmi Srinivasan University, Samayapuram, Trichy, 621112, Tamil Nadu, India, Gopalan M A
Published: July 2024

Objectives: This research article focuses on finding non-zero integer solutions to the Transcendental equation with six unknowns represented by . Methods: There is no universal method for finding integer solutions to Diophantine equations involving surds. Various substitutions strategies are employed to obtain non-zero distinct integer solutions to the surd equation under consideration. Findings: Five different choices of substitutions are utilized to determine many non-zero distinct integer solutions to the transcendental equation with six unknowns in title. Novelty: In this analysis, the transcendental equation with six unknowns given by has been reduced to either Space Pythagorean equation or non-homogeneous ternary quadratic equation through suitable transformations and for which integer solutions can be found elegantly. Keywords: Transcendental Equation With Six Unknowns, Surd Equation, Integer Solutions, Space Pythagorean Equation, Ternary Quadratic Equation
Neutrosophic Logic - A Better Approach to Execute Imprecise Queries Through the Neutrosophic Database Model
Authors: De Soumitra ,   Assistant Professor, CSE, College of Engineering and Management, Kolaghat, West Bengal, India, Mishra Jaydev
Published: July 2024

Objectives: The neutrosophic set has a more powerful ability to process imprecise information compared to the vague set. The objective of the authors is to process the uncertain query using vague as well as neutrosophic logic and compare the result. Methods: Authors have designed a new architecture to process uncertain queries using vague as well as neutrosophic sets. In the architecture at first, the imprecise query has been taken as input. From the inputted imprecise query uncertain data and fuzzy attributes are identified. Next, using the truth membership algorithm the truth membership value between uncertain data and the fuzzy attribute value for each tuple is calculated. This truth membership value is used to obtain the false and indeterminacy membership value to represent the domain of fuzzy attribute in vague or neutrosophic form. Then, the tolerance membership value of each tuple corresponding to the imprecise query is determined by using the similarity measures formula for vague as well as neutrosophic set. Findings: Using the truth membership algorithm and similarity measures formula, the tolerance membership value for each tuple of the relation corresponding to an imprecise query is obtained. If an imprecise query consists of more than one fuzzy attribute then the fuzzy intersection is used to obtain the membership value of the tuple. After obtaining the tolerance membership value of each tuples, the decision maker will provide a threshold (α-cut) value based on which an SQL is generated which fetched a set of tuples whose membership value meets the threshold (α-cut) value for vague as well as neutrosophic set. Authors have considered a patient database to process uncertain queries using a neutrosophic set and claimed neutrosophic set gives better results compared to vague. Novelty: The novelty of this work is to train the computer using a soft set to obtain desired outcomes while processing imprecise query in the database. Keywords: Fuzzy data, Vague set, Neutrosophic Set, Similarity Measures, α -Equal neutrosophic data
Exploring Uptake and Engagement with Community Food-Related Services in Low Income Areas Using the COM-B Model v1
Authors: Stephen Abigail , Allan Julia
Published: July 2024

Background: Low socioeconomic status (SES) is a significant risk factor for obesity and related non-communicable diseases, such as cardiovascular disease and type II diabetes. In Scotland, as in the rest of the UK, deprived areas show higher rates of obesity and overweight compared to the least deprived areas. As of 2018, it is estimated that 14.4 million households did not have the minimum income necessary for a healthy lifestyle. Consequently, food-related services tailored for lower-income populations have been implemented in community settings to address these dietary inequalities. However, there is limited robust evidence supporting these services and their acceptability to the target population. Method: An exploratory cross-sectional survey will be administered to 72 users of community-based food-related services using convenience and snowball sampling methods. The COM-B model will be used to explore factors (specifically barriers and facilitators) that affect how individuals from low socioeconomic populations in Aberdeen City engage with community-based dietary interventions. Levels of food insecurity and engagement with community-based interventions will also be assessed. Results: Responses will be analysed using descriptive and regression analyses with SPSS. Regressions will explore whether capability, opportunity, and motivation (components of the COM-B model) predict engagement with community food-related services. Discussion: This study will provide insights into factors affecting engagement with community-based dietary interventions among low socioeconomic populations. By using the COM-B model, we will identify barriers and facilitators related to capability, opportunity, and motivation. Understanding these factors is crucial for designing effective interventions tailored to low-income populations. Results may reveal key associations between specific factors and engagement with community food services, indicating areas for improvement. This research aims to contribute to the evidence on the effectiveness of community-based food-related services, informing future policies to reduce dietary inequalities and improve health outcomes in deprived areas.
Detection of central and obstructive sleep apneas in mice: a new surgical and recording protocol v2
Authors: Matteoli Gabriele
Published: July 2024

Sleep apnea is a common disorder in humans and consists of recurrent episodes of cessation of breathing or decrease in airflow during sleep. Sleep apneas can be classified as central (CSA) or obstructive (OSA), based on their origin. CSA results from impairments of the inspiratory drive generated by the brainstem with a consequent interruption of diaphragm muscle effort, while OSA occurs due to upper airway obstruction during inspiration with a continued or increased respiratory effort. Mice are valuable tools to expedite the comprehension of the pathophysiology and genetics of sleep apneas and the development of targeted therapies to contrast sleep-disordered breathing and its adverse consequences on health. Therefore, we provide a method for distinguishing between CSA-like and OSA-like events during sleep in mice by simultaneously recording sleep states, breathing pattern, and diaphragm electromyographic activity inside a whole-body plethysmograph. We applied this technique in adult C57BL/6J wild-type mice and in a mouse model of Down syndrome (PMID: 34509609).
Microsatellite instability as a reliable marker of coexisting endometrial cancer in atypical endometrial hyperplasia
Authors: Protasova А. E. , Raskin G. A. , Sobivchak M. S.
Published: July 2024

Background. Endometrial cancer (EC) dominates in the structure of gynecological cancer morbidity. There has been an increase in this nosology in women of reproductive age. The morphological precancerous form of endometrioid adenocarcinoma is endometrial intraepithelial neoplasia (EIN), or atypical endometrial hyperplasia (AEH), that is difficult to diagnose: there is a high percentage of underdiagnosis resulting in a wrong treatment strategy. To improve the accuracy of diagnosis, additional immunohistochemical markers are being studied that are not part of the physician»s routine practice. Extremely promising for the prognosis of endometrial malignancy is the assessment of the functioning of the genes of the DNA mismatched nucleotide repair system (DNA mismatch repair system, MMR).

Aim. To assess the diagnostic value of (microsatellite instability, MSI) in patients with AEH to rule out coexisting endometrial cancer.

Materials and methods. The study includes 72 histological samples: 36 cases of EIN and 36 cases of EC, 14 of which were combined with EIN. To assess the microsatellite status, immunohistochemical staining of specimens was done with the identification of 4 markers, i. e. MLH1, PMS2, MSH2, MSH6.

Results. It was found that out of 36 cases of EIN, only one sample showed loss of the PMS2 and MLH1 genes, which amounted to 3 %; the remaining EIN samples showed microsatellite stability. In 5 (36 %) out of 14 cases of combined EC and EIN pathology, MSI/dMMR was identified. Eight (36 %) out of 22 EC samples were found to have MMR deficiency. Loss of PMS2 increases the likelihood of being classified as EC 9-fold (odds ratio 9.1). With that, the presence of foci of adenocarcinoma in the case of AEH if MSI is confirmed can be asserted with a probability of 93 %. The detection of MSI in a histological sample is more often associated with the presence of EC, while the loss of the PMS2 and/or MLH1 genes increases the likelihood of a cancer diagnosis. If during additional immunohistochemical analysis a loss of these genes is observed, then EC can be diagnosed, even with an ambiguous histological pattern.

Conclusion. Detection of MSI/dMMR in AEH indicates the presence of foci of coexisting endometrioid adenocarcinoma with an extremely high degree of probability. Detection of MSI/dMMR in the treatment of EC is advisable at the stage of diagnosis.
Ovarian neoplasms in pediatric gynecology (literature review)
Authors: Adamyan L. V. , Sibirskaya E. V. , Pivazyan L. G. , Avetisyan D. S. , Zarova E. A. , Tarlakyan V. A. , Krylova E. A.
Published: July 2024

Ovarian neoplasms in children and adolescents are rare pathologies (2.6–3.0 per 100,000 patients a year), however, they are sufficiently relevant in pediatric gynecology nowadays. The age of the patients highly correlates with different histological types of ovarian neoplasms. And this is a reason for discussing this disease in different age groups apart. Unfortunately, there are a number of unresolved issues connected with the etiology, pathogenesis and diagnosis. This paper discusses recent information related with the subject “ovarian neoplasms in pediatric gynecology” and particularly questions which require further study.

The aim of the work is to conduct a review of recent literature which corresponds to this subject and to discover questions which require further study.

The analysis revealed that the etiology and pathogenesis of a number of rare neoplasms has not been discovered fully yet and that can be the cause of the delayed disease diagnostics. Apart from this there are no tools for the preoperative stratification of the risk of malignancy and that can lead to more frequent radical operations for benign tumors.
Background and precancerous diseases of the endometrium during pregnancy
Authors: Chernyshova A. L. , Dil O. S. , Chernyakov A. A. , Truschuk Yu. M. , Antipov V. A. , Arkhipova Ya. I. , Chernyshova A. Е.
Published: July 2024

The article presents an analysis of the current state of the problem of background and precancerous diseases of the endometrium. The issues of etiology and pathogenesis of these conditions are reflected, as well as the features and difficulties of diagnosis, treatment and course in patients with pregnancy are presented. The experience of the Tomsk Oncology Research Institute in the treatment of this pathology is presented, as well as clinical cases that clearly demonstrate the possibility of successful treatment of both endometrioid intraepithelial neoplasia and initial uterine body cancer. It should be noted that the results of treatment of this category of patients are quite good, as well as the expediency of careful dynamic monitoring of this category of patients and the possibility of collegial decision-making in determining treatment tactics at all stages of therapy.
Use of a controlled negative pressure system for the treatment of periprosthetic breast complications
Authors: Chizh I. A. , Semiglazov V. V. , Kolarkova V. V. , Telishevskiy A. V. , Vinogradov I. А. , Gukova V. V. , Zakharenko А. А. , Kolarkov А. V.
Published: July 2024

Background. One of the most common methods of breast reconstruction after mastectomy for malignant tumors is reconstruction using an endoprosthesis. However, this technique is associated with the risk of developing periprosthetic complications. The classic solution to this problem is to remove the endoprosthesis, achieve complete remission of the infectious process and repeat the cycle of reconstructive measures. In this work we present a new approach to the treatment of periprosthetic complications.

Aim. To evaluate the effectiveness of the controlled negative pressure system (CNP) in the treatment of periprosthetic breast complications.

Materials and methods. From 2019 to 2023, the study included 23 patients who underwent combined/complex treatment for breast cancer, including reconstructive plastic surgery with the installation of endoprostheses, and 1 patient who underwent aesthetic surgery was included. All patients experienced various complications after the reconstructive stage: protrusion of the endoprosthesis, ischemia of the flap and/or local inflammation. To relieve the complications that arose, treatment was carried out using a flushing system and a CNP.

Results. The duration of therapy with the sequential installation of a flushing system followed by replacement with a СNP averaged 15 days. In 7 cases out of 24, it was not possible to preserve or reinstall endoprostheses due to thinning of the musculocutaneous flap, resistance of the microflora to the treatment, or relapse of the infectious process. In 17 cases, no complications were recorded after re-installation of endoprostheses for 2 years. As a result of the work, in most cases, within one hospitalization, it was possible to preserve the skin sheath, achieve complete regression of complications and perform repeated reconstructive intervention

Conclusion. In most cases, the use of a CNP allows you to save the bed for the full installation of a new endoprosthesis. To do this, a number of conditions must be met: absence of microflora growth; presence of granulation after treatment; full thickness and integrity of the musculocutaneous flap. Systemic treatment and a history of radiation therapy are not a contraindication to retaining endoprostheses.
Mutations of the PIK3CA gene in patients with breast cancer in the Krasnoyarsk region
Authors: Zyuzyukina A. V. , Yakunina E. Yu. , Borodulina V. I. , Vasilovskaya L. A. , Slepov E. V. , Komissarova V. A. , Zukov R. A.
Published: July 2024

Aim. To identify population characteristics of the PIK3CA gene mutation among breast cancer patients in the Krasnoyarsk region.

Materials and methods. The study included 140 patients with breast cancer with a certain mutation status of the PIK3CA gene, observed at the Krasnoyarsk Regional Clinical Oncology Center named after A.I. Kryzhanovsky. Determination of PIK3CA gene mutations (exons 2, 5, 8, 10 and 21) was carried out using commercial kits on equipment from Roche (Germany). Statistical processing of the obtained data was carried out using Microsoft Excel and Statistica 12 software products. The assessment of the factor of influence on the relapse-free and overall survival was carried out by constructing and comparing Kaplan–Meier curves. The result was considered statistically significant at a significance level of p <0.05.

Results and conclusion. The overall frequency of occurrence of PIK3CA gene mutations is 38.6 %. The most common mutations are H1047X (55.4 %) in exon 21 and E545K (27.8 %) in exon 10. The median age of breast cancer patients with mutation status in the PIK3CA gene was 58.9 [49.0; 67.0] years, median time to relapse or progression was 62.2 [27.0; 84.0] months. There were no statistically significant differences in relapse-free survival between the presence and absence of mutations (p = 0.8). The effect of changes in PIK3CA on a decrease in overall survival rates (p = 0.047) in breast cancer patients was shown.
Environmental Safety of Sustainable Development: Strategy and Implementation Mechanisms
Authors: Shpakovskiy Yu. G. , Zhavoronkova N. G.
Published: July 2024

The paper analyzes the strategic planning system being formed in Russia, the basic principles of which are laid down in the Federal Law of June 28, 2014 No. 172-FZ «On Strategic Planning in the Russian Federation», and also examines its impact on the institution of environmental and legal policy. Using comparative analysis, logical and systemic methods, the author examines the impact of the adopted on November 8, 2021 Decree of the President of the Russian Federation No. 633 «On approval of the Fundamentals of State Policy in the Sphere of Strategic Planning in the Russian Federation» on the formation of a new architecture and methodology for strategic planning in the country, including in the field of ensuring environmental safety. The relevance of this topic is increasing in connection with the course taken to strengthen the state sovereignty of the Russian Federation, build an independent economic and technological policy during the period of the end of «globalism» of a unipolar world on the terms of Western countries. The author’s employs his formulations on the theory and practice of strategic management in the field of environmental safety, which form the base for assessments and certain recommendations.
Autoria feminina: vozes dissonantes no território selvagem// Autoría femenina: voces disonantes en el territorio salvaje
Authors: De Oliveira Dileane Fagundes , Alós Anselmo Peres
Published: July 2024

Resumo: a reflexão a respeito da autoria feminina remete ao processo histórico que produz a escrita de autoria feminina, como um fenômeno cultural, bem como às relações de poder no confronto de interesses que ocorreram na sociedade e que influenciaram seus significados. É preciso refletir sobre o passado para que se possa compreender o presente. Por muito tempo, as mulheres foram representadas pelo discurso masculino na literatura, na filosofia, na biologia, na história e demais áreas do saber, e essas representações ganharam status de verdade a respeito do gênero. Mas algumas dessas mulheres, fugindo do enclausuramento doméstico que lhes era imposto, buscaram inserir-se no âmbito social, que era, por excelência, o espaço reservado ao homem. O presente ensaio tem como objetivo refletir sobre a emersão da autoria feminina na literatura brasileira e, para tanto, coloca a crítica literária feminista (produzida tanto no Brasil quanto no exterior) com um rol de obras literárias consideradas pioneiras, de autoria de mulheres e publicadas ao longo do século XIX.Palavras-chave: literatura brasileira; autoria feminina; crítica literária feminista.Resumen: la reflexión sobre la autoría femenina se refiere al proceso histórico que produce la escritura de autoría femenina, como fenómeno cultural, así como las relaciones de poder en la confrontación de intereses que se dieron en la sociedad y que influirán en sus significados. Es necesario reflexionar sobre el pasado para comprender el presente. Durante mucho tiempo, las mujeres fueron representadas por los discursos masculinos en la literatura, la filosofía, la biología, la historia y otras áreas del saber, y estas representaciones ganaron status de verdad sobre el género. Pero algunas mujeres, huyendo del encierro doméstico que se les imponía, buscaban insertarse en el ámbito social, que era, por excelencia, el espacio reservado a los hombres. Este ensayo tiene como objetivo reflexionar sobre el surgimiento de la autoría femenina en la literatura brasileña y, para tanto, coloca la crítica literaria feminista (producida tanto en Brasil como en el exterior) con una lista de obras literarias consideradas pioneras, de autoría femenina y publicadas a lo largo del siglo XIX.Palabras claves: literatura brasileña; autoría femenina; crítica literaria feminista.
Implementasi Pembelajaran Berdiferensiasi Berbasis Gaya Belajar Peserta Didik Kelas 7 pada Mata Pelajaran Seni Budaya
Authors: Oktiara Rania Erin , Azizah Siti Nur , Izzah Nisda Nabilatul , Naditasari Rizki Izah , Buwono Okvito Eka Putu , Artanto Dhani Febri , Pratamawati E.W. Suprihatin Dyah
Published: July 2024

This study aimed to describe the implementation of differentiated learning based on learning styles in the Seni Budaya subject for 7th-grade students at SMP Negeri 14 Malang and its impact on student learning outcomes and motivation. Employing a qualitative method with a descriptive approach, the research found that differentiated learning can effectively be applied in 7th-grade classes, positively influencing student outcomes and motivation. The implementation spanned a semester, focusing on artistic creation through a project involving traditional dance performances. Students were grouped based on their kinesthetic, auditory, and visual learning styles, allowing tailored engagement with the material. Kinesthetic learners engaged in hands-on activities, auditory learners in listening exercises and discussions, and visual learners in visual aids utilization. Following the traditional dance performances, comprehensive evaluations were conducted, encompassing both formative and summative assessments. This feedback-oriented evaluation aimed at enhancing student skills and understanding. The differentiated learning approach resulted in increased motivation, improved learning outcomes, and the cultivation of character traits consistent with the Pancasila student profile. In conclusion, this study highlights the efficacy of differentiated learning in enhancing academic performance, motivation, and character development. It offers valuable insights for educators seeking to implement student-centered learning strategies effectively.
Pencerahan Di Film Taare Zameen Par: Menyibak Kisah Guru dengan Sikap Luhur
Authors: Majid Abdul Anwaril , Novanti Alifya Devita , Arzhaq Lita Suhul , Nikmah Nurlailatun , Wildana Okky Dinda , Ratnawati Ike
Published: July 2024

Karakter luhur seorang guru yang tercermin dalam film "Taare Zameen Par" dan dampaknya terhadap perkembangan karakter siswa. Guru utama, Ram Shankar Nikumbh, dalam film tersebut memperlihatkan sifat-sifat seperti empati, penerimaan terhadap perbedaan, pemberdayaan, kreativitas dalam pengajaran, keterbukaan, dan kepercayaan pada potensi setiap siswa. Metode penelitian yang digunakan adalah deskriptif dengan analisis naratif terhadap struktur cerita dan pengembangan karakter dalam film. Hasil penelitian menunjukkan bahwa film ini memberikan gambaran yang realistis tentang peran seorang guru dalam mendukung perkembangan karakter siswa, khususnya dalam mengatasi kesulitan belajar. Guru Nikumbh berhasil membawa perubahan positif dalam kehidupan siswa, menciptakan lingkungan pembelajaran yang inklusif, dan mengajarkan nilai-nilai hidup. Meskipun beberapa elemen dramatis digunakan, pesan inti film tetap relevan dan dapat menjadi inspirasi dalam konteks pendidikan. Artikel ini menyimpulkan bahwa film "Taare Zameen Par" efektif dalam mentransmisikan nilai-nilai karakter luhur guru dan dapat menjadi model inspiratif untuk pendidikan sejati.
Perkembangan Kemasan Pertunjukan Festival Nasional Reyog Ponorogo Di Kabupaten Ponorogo Tahun 2016-2022
Authors: Renza Elsava Viola , Hartono Hartono , Gusanti Yurina
Published: July 2024

Perkembangan terjadi akibat adanya pemikiran baru oleh generasi muda yang berjiwa seni tanpa mengubah tradisi yang sudah ada. Festival Nasional Reyog Ponorogo mengalami perkembangan setiap tahunnya, mencakup gerak, penari, tata rias, busana, properti tari, tata lampu, sistem suara, dan tempat pertunjukan. Penelitian ini difokuskan untuk mendeskripsikan perkembangan Festival Nasional Reyog Ponorogo secara sistematis, faktual, akurat, dan sesuai fakta. Penulisan penelitian ini menggunakan metode kualitatif dengan hasil berupa deskriptif kualitatif. Data penelitian diperoleh melalui observasi, wawancara, dan dokumentasi langsung dengan narasumber, yaitu: Marji (seniman reyog dan komposer), Afif Kurniawan (koreografer), Rizal Pahlevi (koreografer muda), Ikke Fislela M.J. (penari), dan Mila Pranesti (penari). Hasil penelitian meliputi: 1) sejarah Reyog Ponorogo; 2) perkembangan Festival Nasional Reyog Ponorogo; 3) Festival Nasional Reyog Ponorogo tahun 2016-2019 periode pertama (sebelum COVID-19); 4) Festival Nasional Reyog Ponorogo tahun 2020-2021 periode kedua (masa COVID-19); 5) Festival Nasional Reyog Ponorogo tahun 2022 periode ketiga (sesudah COVID-19); dan 6) faktor yang mempengaruhi perkembangan kemasan pertunjukan. Saran untuk penelitian selanjutnya adalah mendeskripsikan secara lebih mendalam dan rinci, agar dapat memperkaya referensi bacaan bagi peneliti di masa depan.
Optimalisasi Visual Identity dalam Memperkuat Eksistensi NYCKI Group
Authors: Krisdianto Nova , Pahlevi Andreas Syah
Published: July 2024

Nycki Group adalah sebuah agensi yang termasuk dalam salah satu UMKM sub sektor Desain Komunikasi Visual (DKV) yang bergerak di bidang ekonomi kreatif di Kota Malang. Berdiri pada tahun 2020 oleh Elmiyadi Novia Farma, Nycki Group terdiri dari tiga divisi, yaitu Nycki Studio, Nycki Store, dan Nycki Animation. Selama dua tahun berkiprah di industri kreatif, Nycki Group telah mengerjakan berbagai proyek. Namun demikian, Nycki Group belum banyak dikenal oleh audiens, bahkan di kota domisilinya. Hal ini disebabkan karena mereka selalu menggunakan bendera Event Organizer (EO) untuk berpartisipasi dalam proyek tersebut. Untuk mengatasi masalah ini, Nycki Group mulai mengembangkan sistem dan branding mereka. Salah satu langkah yang diambil adalah mendaftarkan diri sebagai CV. Setelah menjadi CV, perancangan visual identity sangat diperlukan untuk menyampaikan eksistensi Nycki Group, atau dengan kata lain, untuk mendapatkan kesadaran dari konsumen. Perancangan ini bertujuan untuk mengkomunikasikan nilai-nilai yang ingin disampaikan oleh perusahaan kepada konsumennya. Perancangan ini menggunakan metode kualitatif dengan model perancangan oleh Alina Wheeler. Hasil dari perancangan ini berupa GSM (Graphic Standards Manual) dan turunannya yaitu Brand Identity, Stationary, Logo Placement, dan Signage.
Proyecto de aula: estrategia para la articulación de los resultados de aprendizaje en la educación superior
Authors: Ariza Angarita Yuleida , Jiménez Castro Joaquín
Published: July 2024

La formación del Contador Público y su pertinencia para cumplir la promesa de valor del perfil de egresado; lleva implícita la mirada en cómo se gesta y promueven los resultados de aprendizaje desde las universidades, en correspondencia con su naturaleza y apuestas misionales. De allí la necesidad de analizar con enfoque crítico social, el proyecto de aula como estrategia para promover los resultados de aprendizaje en la educación superior. El trabajo de campo fue un estudio de caso en un programa de Contaduría Pública de referencia. Los resultados evidencian el vínculo bidireccional entre la estrategia pedagógica proyecto de aula y los resultados de aprendizaje del perfil de egresado, para alcanzar aprendizaje para toda la vida y trasformaciones sociales. La pertinencia de la formación profesional, indica que la planificación del aula involucra la interacción hilada con todos los actores, sus motivaciones e intereses para catalizar iniciativas de innovación curricular.
Turismo cultural en el Uruguay
Authors: Russi María Teresa
Published: July 2024

Febrero es un buen mes para hablar del turismo y la cultura en el Uruguay. Es la excusa perfecta para entrar en tema al son de un “Borocotó, chas, chas”, o de un “tac tac tac tac, tac tac” emitido por el chico, un piano o un redoblante. Es que así se denominan a los tambores que acompañan el candombe y que hace tan especial la serie de desfiles inaugurales del carnaval más largo del mundo, Patrimonio Inmaterial de la Humanidad , el Carnaval del Uruguay.
En las calles de Uruguay, a partir de los últimos días de enero y durante todo febrero, una energía vibrante y contagiosa se apodera de las ciudades y pueblos. Es el momento del Carnaval, una festividad que combina la creatividad, la música, el baile y la cultura en una celebración única y llena de color. El Carnaval uruguayo es mucho más que una simple fiesta; es una expresión cultural arraigada en la identidad nacional y en la historia del país (Museo del Carnaval, 2019).
Problems and Countermeasures of Senior High School English Vocabulary Teaching in the “Post-Method” Era
Authors: Dong Yilei
Published: July 2024

Vocabulary is the most basic material of language and the key to learn English well. Vocabulary teaching is the most difficult but also the most basic part of English teaching. However, in the traditional high school English vocabulary teaching, teachers and students are still limited by the shackles of “method”, and the phenomena of indoctrination and rote memorization are widespread. As the traditional teaching method system has been criticized and the “eclectic method” has been questioned as lacking a reliable theoretical basis, the field of foreign language teaching has come to the “post-method” stage proposed by Kumaravadivelu. This paper will be based on the three characteristics of the “post-method” teaching concept, and put forward corresponding countermeasures to the problems in high school English vocabulary teaching, in order to find a more concrete, real and dynamic approach to foreign language vocabulary teaching.
Prevalence of smartphone addiction and its association with depression, anxiety among university students, Baghdad 2023
Authors: Algburi Aya Salah Mahdi , Yassin Batool Ali Ghalib
Published: July 2024

Background: Smartphones have simplified our lives and become essential, yet excessive usage may lead to "smartphone addiction". Global youth smartphone addiction is a growing public health concern. Research examines smartphone addiction, depression, anxiety, and depression among university of Baghdad medical and non-medical students. Compare 2 student groups' smartphone addiction rates. Correlate smartphone addiction, anxiety, and depression.
Methods: Comparative cross-sectional research included 383 university of Baghdad students from four colleges. The research included undergraduate university students for a random sampling. From March to June 2023, the smartphone addiction scale-short version (SAS-SV), Beck's depression inventory (BDI), Beck's anxiety inventory (BAI), and sociodemographic were self-reported.
Results: This survey comprised 383 students, 188 (49.1%) from medical institutions and 195 (50.9%) from non-medical colleges. Their ages varied from 18-25, with a mean of 20.8±1.8 years. Most were 20-21 (37.9%) and 260 (67.9%) females. According to SAS-SV cutoffs, 45.17% of medical students and 39.5% of non-medical students were smartphone addicts. Depression affected 38.37% of individuals, ranging from mild (10.7%) to moderate (17.75%) to severe-very severe (9.92%). Survey revealed 50.65% had little anxiety, 31.07 moderate anxiety, and 18.28% severe anxiety. Smartphone addiction significantly correlated with anxiety (p=0.0001) and sadness (p=0.008). Smartphone addiction, anxiety (r=0.29), and depression (r=0.25), among research participants, were positively correlated.
Conclusions: Smartphone addiction was common among study participants, with medical college students being more hooked than non-medical students. Smartphone addiction is correlated with anxiety and despair. Smartphone addiction predicted anxiety and despair.