bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinically Translatable Prevention of Anthracycline Cardiotoxicity by Dexrazoxane Is Mediated by Topoisomerase II Beta and Not Metal Chelation
Authors: Jirkovský Eduard , Jirkovská Anna , Bavlovič-Piskáčková Hana , Skalická Veronika , Pokorná Zuzana , Karabanovich Galina , Kollárová-Brázdová Petra , Kubeš Jan , Lenčová-Popelová Olga , Mazurová Yvona , Adamcová Michaela , Lyon Alexander R. , Roh Jaroslav , Šimůnek Tomáš , Štěrbová-Kovaříková Petra , Štěrba Martin
Published: September 2021

Background:

Anthracycline-induced heart failure has been traditionally attributed to direct iron-catalyzed oxidative damage. Dexrazoxane (DEX)—the only drug approved for its prevention—has been believed to protect the heart via its iron-chelating metabolite ADR-925. However, direct evidence is lacking, and recently proposed TOP2B (topoisomerase II beta) hypothesis challenged the original concept.

Methods:

Pharmacokinetically guided study of the cardioprotective effects of clinically used DEX and its chelating metabolite ADR-925 (administered exogenously) was performed together with mechanistic experiments. The cardiotoxicity was induced by daunorubicin in neonatal ventricular cardiomyocytes in vitro and in a chronic rabbit model in vivo (n=50).

Results:

Intracellular concentrations of ADR-925 in neonatal ventricular cardiomyocytes and rabbit hearts after treatment with exogenous ADR-925 were similar or exceeded those observed after treatment with the parent DEX. However, ADR-925 did not protect neonatal ventricular cardiomyocytes against anthracycline toxicity, whereas DEX exhibited significant protective effects (10–100 µmol/L;
P
<0.001). Unlike DEX, ADR-925 also had no significant impact on daunorubicin-induced mortality, blood congestion, and biochemical and functional markers of cardiac dysfunction in vivo (eg, end point left ventricular fractional shortening was 32.3±14.7%, 33.5±4.8%, 42.7±1.0%, and 41.5±1.1% for the daunorubicin, ADR-925 [120 mg/kg]+daunorubicin, DEX [60 mg/kg]+daunorubicin, and control groups, respectively;
P
<0.05). DEX, but not ADR-925, inhibited and depleted TOP2B and prevented daunorubicin-induced genotoxic damage. TOP2B dependency of the cardioprotective effects was probed and supported by experiments with diastereomers of a new DEX derivative.

Conclusions:

This study strongly supports a new mechanistic paradigm that attributes clinically effective cardioprotection against anthracycline cardiotoxicity to interactions with TOP2B but not metal chelation and protection against direct oxidative damage.
A Novel Mechanism Underlying Inflammatory Smooth Muscle Phenotype in Abdominal Aortic Aneurysm
Authors: Cai Dunpeng , Sun Chenming , Zhang Gui , Que Xingyi , Fujise Ken , Weintraub Neal L , Chen Shi-You
Published: September 2021

Rationale:

Abdominal aortic aneurysm (AAA) is a permanent and localized dilatation of abdominal aorta with potentially fatal consequence of aortic rupture. No effective pharmacological approach has been identified to limit AAA progression and rupture. AAA is characterized by extensive aortic wall matrix degradation that contributes to arterial wall remodeling and eventual rupture, in which smooth muscle cell (SMC) phenotypic transition and MMPs (matrix metalloproteinases), especially MMP2 (matrix metalloproteinase-2) and MMP9, play critical roles.

Objective:

Our previous study showed that ADAR1 (adenosine deaminases acting on RNA 1) regulates SMC phenotype, which prompted us to study if ADAR1 is involved in AAA development.

Methods and Results:

We used Ang II (angiotensin II) infusion ApoE
−/−
mouse model combined with ADAR1 global and SMC-specific knockout to study the role of ADAR1 in AAA formation/dissection. Aortic transplantation was conducted to determine the importance of vascular cell ADAR1 in AAA development/dissection. Primary cultured SMC were used to study how ADAR1 regulates the inflammatory SMC phenotype and MMP production/activity. Patient specimens were obtained to investigate the relevance of ADAR1 expression to human AAA disease. ADAR1 was induced in abdominal aortic SMC in both mouse and human AAA tissues. Heterozygous knockout of ADAR1 diminished the Ang II–induced AAA/dissection in ApoE
−/−
mice. Mouse aortic transplantation showed that ADAR1 in vascular cells was essential for AAA formation. SMC-specific ADAR1 knockout reduced experimental AAA formation/dissection. Mechanistically, ADAR1 interacted with HuR (human antigen R) to increase the stability of MMP2 and MMP9 mRNA, leading to increased MMP levels and activities.

Conclusions:

ADAR1 is novel regulator of AAA development/dissection, and thus may represent a potential new therapeutic target to hinder AAA growth and rupture.
Effective typification of Ophrys apifera (Orchidaceae; Orchidoideae)
Authors: FERRER-GALLEGO P. PABLO
Published: September 2021

Ophrys apifera Hudson was previously considered to have been lectotypified by Künkele and Baumann in 1998 with an illustration published by Matthias Lobel in 1581. However, Hudson did not include any references to Lobel in the protologue. Therefore, the typification by Künkele and Baumann is here briefly discussed and superseded because is being contrary to Art. 9.3 of the International code of nomenclature for algae, fungi, and plants (Shenzhen Code). The name is lectotypified here with an illustration published by Bauhin and Cherler in 1651. Unfortunately, this illustration does not show several diagnostic characters to distinguish O. apifera from other related species. Therefore, for a precise circumscription of the name, an epitype is proposed of a complete specimen preserved at K.
A new species of Suwallia Ricker, 1943 from Japan, and the identity of Alloperla teleckojensis Šámal, 1939 (Plecoptera: Chloroperlidae)
Authors: LI WENLIANG , WANG YINGYING , WANG YING , LI WEIHAI
Published: September 2021

A new species of the genus Suwallia from Japan, S. kawaii sp. n. is described, illustrated with color images and compared with related taxa. Based on the examination of the holotype, we consider Alloperla teleckojensis Šámal, 1939 is synonymized with Alloperla deminuta Zapekina-Dulkeit, 1970, and the former was a valid name. The name S. errata sp. n. is given for the widespread species hitherto known as Suwallia teleckojensis sensu Zapekina-Dulkeit (1955).
An Implicit – Not Explicit – Understanding of Hurricane Storms
Authors: Whitmer Daphne E. , Sims Valerie K.
Published: September 2021

The goal of this research was to examine students’ risk perception of hurricanes and hurricane-related storms to address a critical gap in the literature. Participants were asked to rate their perceptions of a tropical storm, tropical depression, and category 1 through 5 hurricanes on five dimensions and define the storms based on wind speed. Lastly, individual differences in sex and growing up on the coast were examined to determine whether they explain differences in risk perceptions. Findings showed that participants’ perceptions of category 1 through 5 hurricanes followed a linear pattern and each pair was perceived to be significantly different. However, participants rated tropical storm and tropical depression as more severe than a category 1 hurricane and were unable to define any of the storms based on wind speed. In fact, coastal natives were less accurate at defining the storms and believed the low-tier storms to be less severe than non-coastal natives. This research is the first to show that people implicitly understand the Saffir-Simpson Scale that defines category 1 through category 5 hurricanes, but not the lesser-tiered storms. The present work demonstrates a need for enhanced education of hurricanes, as students do not make important distinctions at the lower-end of the hurricane scale.
Walking Impairment Questionnaire and Walking Tests are Reliable Indicators of Success of Treatment of Peripheral Artery Disease
Authors: Poredos Pavel , Boc Vinko , Zlajpah Urska , Mangaroska Ana Spirkoska , Poredos Peter
Published: September 2021

The functional capacity of patients with peripheral arterial disease (PAD) represents an important indicator of patient health and quality of life. The aim of this prospective study was to investigate the validity of a walking impairment questionnaire (WIQ) compared with walking tests for the estimation of the therapeutic effect of lower limb revascularization. The study included 36 patients with PAD in whom successful percutaneous revascularization of a lower limb was performed due to disabling intermittent claudication. Before the revascularization procedure and 4–6 weeks after successful revascularization, clinical examination, ankle brachial index (ABI) measurement, 6-min walk test, treadmill test, and WIQ were performed. After revascularization, significant improvement in walking capacity was shown by both 6-min walk test and treadmill exercise test as well as with WIQ. However, the increase in ABI was borderline. Significant correlations between improvement of 6-min walk test and treadmill exercise test results and the sum of WIQ points were found. The ABI was significantly correlated with treadmill maximal walking distance only. According to our results, the WIQ correlates well with walking tests and is a reliable indicator of effective revascularization of lower limb arterial occlusions, even in patients with a nonsignificant improvement of the ABI.
The Study of Religion and the Canadian Social Order
Authors: Seljak David
Published: September 2021

In his book From Seminary to University: An Institutional History of the Study of Religion in Canada, Aaron Hughes provides a unique analysis of how the study of religion developed throughout the history of Canada by examining the evolution of its institutional context, that is, from faith-based seminaries and theological colleges to secular departments of religious studies. He situates these institutional changes in the development of the Canadian social order. In this uniquely Canadian context, the study of religion moved, Hughes notes, “from religious exclusion to secularism, from Christocentrism to multiculturalism, and from theology to secular religious studies.” While this is an important and original argument, Hughes offers only a cursory analysis of the unique developments in francophone Quebec universities (as he readily admits) and ignores the study of religion in other disciplines. Moreover, while Hughes traces the motivation for the transformation of the study of religion in the 1960s to the new ethno-religious diversity of Canada, I argue that it should be traced to a growing liberal cosmopolitanism that had infiltrated Canadian society, including its churches, seminaries, and theological colleges. Hughes does not adequately explore the religious roots of why Canadian Christians decided to secularize the study of religion. Finally, while Hughes examines patriarchy and colonialism in his analysis of the study of religion in earlier periods, he drops these topics in his discussion of the secularization of the study of religion, which did not address either of these issues sufficiently.
“I Want to Be Safe…And I Also Want a Job”: Career Considerations and Decision-Making Among Transgender Graduate Students
Authors: Goldberg Abbie E. , Matsuno Emmie , Beemyn Genny
Published: September 2021

Trans individuals experience unique stressors related to their careers, such as discrimination, workplace harassment, navigating transition, and disclosure of their identity. The current study examined the experiences of 30 trans graduate students with regard to career decision-making. In total, 19 identified as at least one nonbinary identity and 11 were binary trans-identified (trans men and trans women). Thematic analysis of in-depth interview transcripts revealed the following major themes: (a) Role of Gender Minority Stress During Graduate School in Career Development, (b) Key Considerations Related to Future Jobs or Career Paths (e.g., whether fields or specific jobs are trans-friendly), (c) Outness as a Key Consideration in the Job Application Process, and (d) the Role of Resources and Supports in Career Development. Our findings highlight the unique stressors for trans individuals in the career decision-making and job application processes and the unique challenges faced by nonbinary job seekers.
Career commitment among social workers: The contribution of personal, organizational, and vocational factors
Authors: Freund Anat , Koltun Guil Javier , Zriker Amit
Published: September 2021

Despite today’s considerable changes in the labor market, studies on the career commitment of social workers remain scarce. The current study focuses on the personal, organizational, and vocational factors of social workers’ career commitment. The study included 251 social workers from various organizations in Israel. Findings show that their career commitment is positively correlated with Protean and Boundaryless career patterns, as well as with their perceived career success. These findings could contribute in developing tools that could increase social workers’ career commitment, which in turn would enable them to be more effective at work, to the benefit of their clients.
Shifting Peaks and Cumulative Consequences: Disqualifying Convictions in High-security Jobs
Authors: Denver Megan , Behlendorf Brandon
Published: September 2021

Objectives:

Disqualifying conviction lists (DCLs) bar applicants with certain convictions within specified timeframes from employment. Using proposed federal legislative changes in the aviation sector as a case study, we examine whether convictions under the existing policy are associated with subsequent arrest. Then we consider the implications of proposed expansions—arrests instead of convictions and a longer look-back window—on employment restrictions.

Methods:

Since DCLs exclude ineligible applicants with conviction records, we use a large, single-state sample of diverse criminal histories. We compare subsequent arrest rates across offense types, consider variations in hazard patterns, and project exclusion estimates based on current and anticipated policy reforms.

Results:

Only half of the disqualifying offenses have consistently higher recidivism rates than non-disqualifying offense types. Over 20 percent of the sample would be barred from employment, policy extensions double this estimate, and exclusions are age-graded, shifting a peak conviction age of 20 years old to a peak “consequence age” of 28.

Conclusions:

Including a narrower set of offenses would reduce those automatically disqualified in our study context by nearly 20 percent, or 39,000 individuals. Instead of expanding the DCL scope, successful criteria should be both effective in prediction and narrow in application.
A Review and Analysis of Single-Case Research Examining Adolescent Participation in IEP Meetings
Authors: Sanderson Kelli A. , Goldman Samantha E. , Rojas Amanda
Published: September 2021

The purpose of this systematic review and meta-analysis was to identify and synthesize single-case research examining interventions used to increase the quantity and/or quality of participation by adolescents with disabilities during Individualized Education Program (IEP) meetings. For studies meeting quality indicators, we used visual analysis, Tau-U, and standardized mean difference to synthesize outcomes, including maintenance and generalization of effects. We identified seven studies examining quality of participation and eight studies examining quantity of participation that met our inclusion criteria; however, only three studies from each group met quality standards. Overall, interventions positively influenced student contributions at IEP meetings. When measured, increased quantity and quality of participation maintained over time and generalized to real IEP meetings. Implications for research and practice are discussed.
Tamoxifen administration induces histopathologic changes within the lungs of Cre-recombinase-negative mice: A case report
Authors: Wyatt Kara D , Sakamoto Kaori , Watford Wendy T
Published: September 2021

Tamoxifen is commonly used as a cancer treatment in humans and for inducing genetic alterations using Cre-lox mouse models in the research setting. However, the extent of tamoxifen off-target effects in animal research is underappreciated. Here, we report significant changes in cellular infiltration in Cre-recombinase-negative mice treated with tamoxifen intraperitoneally. These changes were noted in the lungs, which were characterized by the presence of alveolitis, vasculitis, and pleuritis. Despite significant immunological changes in response to tamoxifen treatment, clinical symptoms were not observed. This study provides a cautionary note that tamoxifen treatment alone leads to histologic alterations that may obscure research interpretations and further highlights the need for the development of alternative mouse models for inducible Cre-mediated deletion.
A New System of Cantonese Tones? Tone Perception and Production in Hong Kong South Asian Cantonese
Authors: Yu Alan C. L. , Lee Crystal W. T. , Lan Chen , Mok Peggy P. K.
Published: September 2021

Studies in language contact have identified many instances of linguistic variation and grammatical innovations introduced by speakers from multi-ethnic urban neighborhoods. This study focuses on the variety of Cantonese spoken by South Asian youths in Hong Kong, specifically their production and perception of Hong Kong Cantonese tones. Our findings show that the South Asian Cantonese speakers have a smaller tonal inventory than the canonical six-tone system of standard Hong Kong Cantonese and their tonal discrimination abilities are also more impoverished relative to their ethnic Chinese peers. Further analysis shows a positive correlation between tonal discrimination accuracy and tonal realization distinctness among the South Asian speakers, but not among the ethnic Chinese. These findings suggest that South Asian Cantonese speakers might have developed a distinct tone system from their ethnic Chinese peers.
Conversion, apostasy, or hybridity? The terrible, troubled, transformative experience of Paul as exemplar for missiology in an age of multiplicity
Authors: Avila Kaminski Amanda
Published: September 2021

Scholars and practitioners alike celebrate the Apostle Paul as an exemplar of Christian mission. But few emphasize how the ministry and practices of the biblical author developed amid incredible intrareligious conflict and relational wreckage. Embroiled in tension over doctrinal and ritual changes, plagued by vitriolic attacks on his character, and caught up in a web of splintered relationships, Paul offers contemporary people of faith a lesson on unity in diversity for mission in an age of hybridity. Embracing the “terrible and troubled” experience of Paul enables us to bring into relief a transformative hermeneutical strategy for negotiating new forms of religious life and multiplicity in belonging. This article will show how competing cultural and religious codes shaped the Apostle’s symbolic universe, causing violence, tension, conflict, and rejection, before reconciling in an ethic of love in hybridity. After making a case for the reclamation of the troubled textual Pauline experience over an idealized picture of early Christian mission, I will argue for the critical importance of Paul’s Damascus Road experience by narratively resituating it from typological “conversion” story to mystical encounter with the Holy Other that catalyzed a new religious imagination for cultivating a revolutionary egalitarian, inclusive pattern of religious life. Then, I will use Paul’s narrative from Galatians and his treatment of holiness in 1 Corinthians to show how ruptures in the Apostle’s journey led him through fractures and failures into spiritual maturity. By welcoming the gendered, classed, and cultic other into fellowship, Paul also found his quintessential theological insights: the new creation and life in the Spirit. Paul’s response to the invitation of the risen Jesus and his record of the missional life that followed offers missiology a way through monocultural approaches and theological exclusivism into a constructive spirituality that unifies radically different factions into one holy, hybrid body.
“AmeriKenyan”: Lived Acculturation and Ethnic Identification of Kenyan Natives During Their Youth
Authors: Onwong’a Jana R. , Slaten Christopher D. , McClain Shannon
Published: September 2021

This qualitative study investigated the immigration, acculturation process, and ethnic identity experiences of six Kenyan emerging adults who immigrated to the United States during their adolescent years. Themes emerged from the data to describe their (a) immigration experience, (b) acculturation process into an individualistic culture with more of a Western worldview, (c) ethnic and racial identities, and (d) emotional response and coping. Subthemes and additional factors illustrated their experience as it relates to social life, academics, cultural context, family values, and more. Implications for multicultural psychology research and practice are addressed.
The Long-Term Impact of Undergraduate Internships and Research Experiences in Psychology: An Alumni Survey Study
Authors: Budesheim Thomas L. , Khanna Maya M. , Klanecky Earl Alicia K. , Guenther Corey L.
Published: September 2021

Background

Faculty tout the value of undergraduate internships and research experience, but the long-term benefits are unclear for students pursuing different careers.

Objective

We assessed the self-perceived benefits of internships and research experiences for alumni pursuing different careers, as well as how enduring these perceived benefits were.

Method

Psychology alumni (N = 498) rated their skills garnered as an undergraduate, the usefulness of their psychology training, and overall satisfaction with their psychology education. We examined the effects of internships and research experience on their ratings and how ratings varied by chosen post-graduation path and graduation year.

Results

Both internships and research experiences were associated with higher ratings of skills, greater perceived usefulness of their psychology degree, and higher satisfaction with their education even decades later. Alumni entering the workforce found internships more beneficial than did those entering graduate or professional programs. Those who had both an internship and research experience perceived significantly greater benefits than those who had only one type of experience.

Conclusion

Undergraduate internships and research experiences have enduring positive impacts but are differentially useful depending upon the alum’s chosen career path.

Teaching Implications

Faculty should encourage students to pursue experiences most beneficial for the student’s career trajectory.
Hakka migrant hometown associations: Development and social network patterns
Authors: Chang Han-Pi , Chang Chen-Chi , Chang Wei-An
Published: September 2021

This study sought to review the development of Hakka migrant hometown associations and to explore the social network patterns of these associations. To better understand migrant associations in different contexts, research was conducted in various countries or regions. The study examined the relationships between and among associations from an organizational perspective. Using the criteria of density and centralization, the social network patterns are classified into four network types: (1) hierarchical, (2) clique, (3) peer-to-peer, and (4) formative. According to the findings, the network characteristics of different associations enable Hakka associations to flourish in the immigration countries and preserve Hakka culture.
Successful Endoscopic Sclerotherapy Using Lauromacrogol Injection for Laryngopharyngeal Hemangioma
Authors: Qu Hongyang , Lei Xia , Hu Lin , Yin Xiao , Du Xiaodong , Zhang Lei , Sun Changling
Published: September 2021

Objectives: This study aims to investigate the efficacy and safety of local lauromacrogol injection in the treatment of hypopharyngeal hemangioma. Methods: From Aug 2015 to May 2021, 13 consecutive patients suffering from hypopharyngeal hemangioma underwent local lauromacrogol injection assisted by endoscope in this prospective clinical series. All patients were followed up regularly and the therapeutic effects and complications were observed. Results: A total 13 of patients were enrolled, including 11 men and 2 women, with an average age of 48.5 years (range 25–76 years). The sizes of the hemangioma ranged from 0.5 × 1.0 cm to 3.5 × 3.5 cm. After 1 to 40 months of follow-up, 12 patients were cured and 1 was significantly effective after 1 to 4 (mean 1.8) injections. All patients suffered varying degrees of postoperative pain or foreign body sensation. 3 patients were significantly affected by local swelling of the injection site, 2 of which underwent prophylactic tracheostomy postoperatively and 1 patient returned to the ward with endotracheal intubation postoperatively. No complications such as mucosal ulceration, fever, and allergies occurred. Conclusions: Lauromacrogol injection is a safe and effective method to treat hypopharyngeal hemangioma.
Psychometric Analysis of the 2016 Ohio Long-Term Care Facilities Family Satisfaction Scale
Authors: Nwakasi Candidus , Mehri Nader , Parajuli Jyotsana
Published: September 2021

Although the Ohio Family Satisfaction Survey (OFSS) has been around since 2002 as an important indicator of long-term care facilities’ performance, the validity of this scale has not been evaluated. Using the Robust Maximum Likelihood Estimator Method in Mplus, psychometric analysis involving second-order construct validity or hierarchical construct validity was conducted using responses from 1636 facilities including nursing homes and residential care facilities ( N = 32,424). The results showed that OFSS retained the 7-factor structure for the 7 domains and the factor loadings for each domain were above 0.5. It is crucial to include families’ input regarding quality of long-term care facilities as some older residents, especially those with moderate to severe cognitive impairments may be unable to provide consistent and comprehensive inputs about the quality of care and services they receive. Therefore, validation of the OFSS has an important implication for quality improvement practice.
The COVID-19 Pandemic Crisis in Malaysia and the Social Protection Program
Authors: Daud Sity
Published: September 2021

The main objective of this study is to discuss the impact of COVID-19 pandemic on vulnerable groups in Malaysia. The study used qualitative research methods based on primary and secondary data. Primary data was collected through government documents already published and previous interviews conducted in 2018 by the author on poverty and social protection programs. This article concludes that relief measures now should be linked with the long-term recovery measures to assure greater resilience in the face of potential future shocks.
When Does Status Transfer between People? A Crowdsourced Experiment on the Scope of Status by Association
Authors: Overton Jon
Published: September 2021

It is well known in social psychology that people are judged by the company they keep, but when and how does that company affect how individuals are evaluated? This article extends expectation states theory to explain associative status. The theory predicts that the status value of former coworkers will “spill over” to positively predict a person’s status position in a new task with new coworkers. A series of crowdsourced experiments finds that status spreads to a person from a former interaction partner. The status of one’s associates predicts deference behavior only when the previous and current task contexts rely on similar abilities. Meanwhile, explicitly evaluated status and performance expectations respond to the status of associates regardless of how interaction contexts are related. The present findings highlight the importance of role relationships and task contexts as moderators that regulate whether status transfers from one person to another.
Without mandate: James Bernauer from the ethics of thought to historical memory
Authors: Tanke Joseph
Published: September 2021

This special issue of Philosophy and Social Criticism is dedicated to James Bernauer, S.J. on the occasion of his retirement from full-time teaching. It contains original essays from Bernauer’s students, friends, and fellow travelers that were commissioned for the purpose of commemorating this occasion. These essays provide readers with an opportunity to reflect upon Bernauer’s contributions to fields of academic inquiry as diverse as Arendt and Foucault studies, the philosophy of religion, and Holocaust studies. Since our purpose was to honor the life and work of James Bernauer, and not simply comment on it, the contributors to this volume have each attempted to develop and extend, rather than simply rehash and recapitulate, the concerns they find articulated in Bernauer’s publications.
Psychological Autopsy Studies of Suicide in South East Asia
Authors: Arafat S.M. Yasir , Menon Vikas , Varadharajan Natarajan , Kar Sujita Kumar
Published: September 2021

Background:

Psychiatric disorders have been identified as an important risk factor for suicide. However, different psychological autopsy studies have revealed different prevalences at different times and places.

Objective:

We aimed to see the distribution of psychological autopsy studies and the prevalence of mental disorders among suicides and identify major risk factors in Southeast Asian countries.

Method:

We scrutinized psychological autopsy studies published in the World Health Organization (WHO) South-East Asia (SEA) region countries. We also searched the available bibliographies to identify the studies in the region so that all the possible articles could be included.

Results:

Out of the 11 countries, 14 psychological autopsy studies were identified in five SEA countries (Bangladesh [1], India [9], Indonesia [1], Nepal [1], and Sri Lanka [2]). Seven studies (50%) used a case-control study design, and eight (57.1%) were carried out in urban settings. The prevalence of psychiatric disorders in case-control studies was from 37% to 88%. Stressful life event was identified as a major risk factor in all the case-control studies.

Conclusion:

Psychological autopsy studies have not been conducted in 6 out of 11 countries of the SEA region. The presence of pre-existing psychiatric morbidity and stressful life events were the two most common risk factors noted across settings, even though there is wide heterogeneity in samples, study design, instruments, and study settings.
Adaptation and continuous learning: integrative review of coping strategies of palliative care professionals
Authors: Sapeta Paula , Centeno Carlos , Belar Alazne , Arantzamendi María
Published: September 2021

Background:

Coping is essential to manage palliative care professionals’ challenges. The focus has been on the effects of coping mechanism; however, little is known about coping itself in palliative care.

Aim:

To synthesise evidence of coping strategies in palliative care professionals, and how different strategies play roles over time.

Design:

Systematically conducted integrative review.

Data sources:

PubMed; CINAHL; Medline; PsycINFO and B-ON were searched (1996–2021) combining ‘coping’ AND ‘palliative care’. A predefined data extraction sheet was developed to report data. Two researchers performed constant comparative analysis using Nvivo®.

Results:

Thirty-one studies were included. Four main strategies with recurrent reference to time were found: (a) proactive coping, involving activities to achieve self-confidence and control situations and emotions; (b) self-care based coping, including self-protection and self-awareness activities, with behavioural disconnection; (c) self-transformation coping, involving activities to accept limits; and (d) encountering deep professional meaning, is a coping mechanism based on meaning, frequently considering the deepest meaning of work. The dynamic and influencing factors were training, team interaction, professional motivation and family. They were usually protective factors, though sometimes they represented risk factors. The emotional burden associated with healthcare and systemic stressors were always risk factors. An explanatory model describes a complex and dynamic process, in which everyday strategies and more introspective strategies are combined.

Conclusions:

The model showed a process of adaptation and learning to persevere in palliative care. It changes over time under factors and strategies, and evolves in a personal and professional transformation, parallel to the working life. It would be worth assessing coping in healthcare professionals who chose to leave palliative care and to investigate the reasons they did so and their coping mechanisms.
Cerebral haemodynamic response to somatosensory stimulation in preterm lambs and 7–10-day old lambs born at term: Direct synchrotron microangiography assessment
Authors: Inocencio Ishmael M , Tran Nhi T , Nakamura Shinji , Khor Song J , Wiersma Manon , Stoecker Katja , Maksimenko Anton , Polglase Graeme R , Walker David W , Pearson James T , Wong Flora Y
Published: September 2021

Neurovascular coupling has been well-defined in the adult brain, but variable and inconsistent responses have been observed in the neonatal brain. The mechanisms that underlie functional haemodynamic responses in the developing brain are unknown. Synchrotron radiation (SR) microangiography enables in vivo high-resolution imaging of the cerebral vasculature. We exploited SR microangiography to investigate the microvascular changes underlying the cerebral haemodynamic response in preterm (n = 7) and 7–10-day old term lambs (n = 4), following median nerve stimulation of 1.8, 4.8 and 7.8 sec durations.

Increasing durations of somatosensory stimulation significantly increased the number of cortical microvessels of ≤200 µm diameter in 7–10-day old term lambs (p < 0.05) but not preterm lambs where, in contrast, stimulation increased the diameter of cerebral microvessels with a baseline diameter of ≤200 µm. Preterm lambs demonstrated positive functional responses with increased oxyhaemoglobin measured by near infrared spectroscopy, while 7–10-day old term lambs demonstrated both positive and negative responses. Our findings suggest the vascular mechanisms underlying the functional haemodynamic response differ between the preterm and 7–10-day old term brain. The preterm brain depends on vasodilatation of microvessels without recruitment of additional vessels, suggesting a limited capacity to mount higher cerebral haemodynamic responses when faced with prolonged or stronger neural stimulation.
Comparison of polyetheretherketone cables and stainless steel wires for sternal fixation after median sternotomy
Authors: Shu Duanchao , Li Jianpeng , Zhao Yixin , Yang Yan
Published: September 2021

Objective

To compare the sternal fixation effect of a polyetheretherketone (PEEK) cable product and stainless steel wire after median sternotomy.

Methods

A multicentre retrospective clinical trial was conducted in patients that underwent median sternotomy for a range of surgical reasons. The sternum was fixed using PEEK sternal cables in the experimental group and stainless steel wires in the control group. The general patient state, product manoeuvrability, bone and wound healing state and blood test results were evaluated at seven visits during the preoperative, surgical and follow-up periods.

Results

A total of 108 patients (54 in each group) were included in the analysis at the final 180-day follow-up. The sternum was successfully closed using PEEK cables or steel wires in all patients and all healed well. No pathological changes were found on the X-ray imaging. Computed tomography imaging confirmed ideal fracture healing. No significant difference was found between the experimental group and the control group in outcomes.

Conclusion

PEEK cables are easy to implant and show desirable effectiveness in sternal fixation without any observed side-effects.
Predicting medication nonadherence risk in the Chinese type 2 diabetes mellitus population – establishment of a new risk nomogram model: a retrospective study
Authors: Wang Fa-Cai , Chang Wei , Nie Song-Liu , Shen Bing-Xiang , He Chun-Yuan , Zhao Wei-Chen , Liu Xiao-Yan , Lu Jing-Tao
Published: September 2021

Objective

To investigate the risk factors of medication nonadherence in patients with type 2 diabetes mellitus (T2DM) and to establish a risk nomogram model.

Methods

This retrospective study enrolled patients with T2DM, which were divided into two groups based on their scores on the Morisky Medication Adherence scale. Univariate and multivariate logistic regression analyses were used to screen for independent risk factors for medication nonadherence. A risk model was then established using a nomogram. The accuracy of the prediction model was evaluated using centrality measurement index and receiver operating characteristic curves. Internal verification was evaluated using bootstrapping validation.

Results

A total of 338 patients with T2DM who included in the analysis. Logistic regression analysis showed that the educational level, monthly per capita income, drug affordability, the number of drugs used, daily doses of drugs and the time spent taking medicine were all independent risk factors for medication nonadherence. Based on these six risk factors, a nomogram model was established to predict the risk of medication nonadherence, which was shown to be very reliable. Bootstrapping validated the nonadherence nomogram model for patients with T2DM.

Conclusions

This nomogram model could be used to evaluate the risks of drug nonadherence in patients with T2DM.
Cement-associated thrombotic embolism in the inferior vena cava and bilateral iliac veins after percutaneous vertebroplasty: a case report
Authors: Hu Yunxiang , Wang Yufei , Yu Zhimin , Li Xinxian
Published: September 2021

Percutaneous vertebroplasty (PVP) was first reported in 1987 for treating vertebral hemangiomas. PVP is also an effective treatment for osteoporotic vertebral compression fracture that mainly involves a percutaneous injection of polymethylmethacrylate. Severe complications of PVP have been reported in recent years. However, to the best of our knowledge, cement-associated thrombotic embolism in the inferior vena cava and bilateral iliac veins after PVP has rarely been reported. We experienced a patient with cement-associated thrombotic embolism in the inferior vena cava and bilateral iliac veins after PVP. Fortunately, after conservative therapy, we achieved a satisfactory result. Unfortunately, we could not explain the cause of the cement leakage and formation of the thrombotic embolism. We believe that surgeons should have a better understanding of the fracture pattern and anatomy of the vertebral venous net system. They should also perform meticulous imaging monitoring with slower pushing of the cement to minimize the risks during the PVP. This case report highlights a rare, but potentially life-threatening, complication of PVP. Surgeons need to be aware of the possibility of cement leakage and the formation of cement-associated thrombotic embolism so that they are much more vigilant when performing PVP.
The mechanism and neural substrate of musical emotions in the audio-visual modality
Authors: Zhou Xin , Wu Ying , Zheng Yingcan , Xiao Zilun , Zheng Maoping
Published: September 2021

Previous studies on multisensory integration (MSI) of musical emotions have yielded inconsistent results. The distinct features of the music materials and different musical expertise levels of participants may account for that. This study aims to explore the neural mechanism for the audio-visual integration of musical emotions and infer the reasons for inconsistent results in previous studies by investigating the influence of the type of musical emotions and musical training experience on the mechanism. This fMRI study used a block-design experiment. Music excerpts were selected to express fear, happiness, and sadness, presented under audio only (AO) and audio-visual (AV) modality conditions. Participants were divided into two groups: one comprising musicians who had been musically trained for many years and the other non-musicians with no musical expertise. They assessed the type and intensity of musical emotion after listening to or watching excerpts. Brain regions related to MSI of emotional information and default mode network (DMN) are sensitive to sensory modality conditions and emotion-type changes. Participants in the non-musician group had more, and bilateral distribution of brain regions showed greater activation in the AV assessment stage. By contrast, the musician group had less and lateralized right-hemispheric distribution of brain regions.
“The music gets through”: Experiences of classical composers and observations of hospitalized adolescents in a music-based intervention
Authors: Cascarino Emily , Knight Tess , Macdonald Jacqui A
Published: September 2021

Music is a valuable aid for hospitalized adolescents as they navigate normative and non-normative stressors. Music-based interventions link these adolescents with composers who write music designed to facilitate emotional well-being; yet little is known about how each engage and find meaning in these interventions. This study examines the motivations and musical choices of composers of music for mental health, as well as how hospitalized adolescents engage in and benefit from the creative process. Ten adolescents with extensive hospital experiences, six composers, two hospital staff, and one program coordinator were observed and/or interviewed in a music-based intervention. Interpretative phenomenological analysis (IPA) of interviews with composers, coordinators, and hospital staff was performed to gain deep understanding of psychosocial benefits for all groups. This was supplemented by ethnographic observation of the program. Qualitative themes of Composer Reasoning, Listener Influence, and Adolescent Engagement revealed interplay of challenges and rewards for composers and adolescents. Composers reported positive change in adolescent mood and engagement and reflected on this within the context of meaning-making and social connection. This study demonstrates the potential value of music as a tool to promote positive identity and contributes to the body of research forging a connection between the arts and health care.
Incidence of spontaneous intracranial hypotension in a community: Beverly Hills, California, 2006–2020
Authors: Schievink Wouter I , Maya M Marcel , Moser Franklin G , Simon Paul , Nuño Miriam
Published: September 2021

Background

Spontaneous intracranial hypotension is diagnosed with an increasing frequency, but epidemiologic data are scarce. The aim of this study was to determine the incidence rate of spontaneous intracranial hypotension in a defined population.

Methods

Using a prospectively maintained registry, all patients with spontaneous intracranial hypotension residing in Beverly Hills, California, evaluated at our Medical Center between 2006 and 2020 were identified in this population-based incidence study. Our Medical Center is a quaternary referral center for spontaneous intracranial hypotension and is located within 1.5 miles from downtown Beverly Hills.

Results

A total of 19 patients with spontaneous intracranial hypotension were identified. There were 12 women and seven men with a mean age of 54.5 years (range, 28 to 88 years). The average annual incidence rate for all ages was 3.7 per 100,000 population (95% confidence interval [CI]: 2.0 to 5.3), 4.3 per 100,000 for women (95% CI, 1.9 to 6.7) and 2.9 per 100,000 population for men (95% CI, 0.8 to 5.1).

Conclusion

This study, for the first time, provides incidence rates for spontaneous intracranial hypotension in a defined population.
Competitive Effects of Joint Ventures in the International Airline Industry
Authors: Tan Guofu , Zhang Yinqi
Published: September 2021

In the past two decades, many international airline carriers have expanded their cooperation by forming various joint ventures (JVs). One key feature of these JVs is that they require carriers to determine certain airfares jointly and integrate their operations as a single carrier in the market for international air travel. This paper tries to evaluate the impact of JVs on airfares. The focus is on a set of behind-to-gateway markets between a non-gateway U.S. city and a foreign gateway city, where both online and codeshare flights are offered, to study how the airfares of online flights are affected after carriers form JVs. A new hypothesis is discussed that JVs increase the airfares of online flights. Based on this hypothesis, an empirical model is built to evaluate the Oneworld alliance’s transatlantic JV established in July 2010. This empirical analysis, which uses the U.S. Department of Transportation (U.S. DOT)’s Airline Origin and Destination Survey (DB1B) international data from 2008 to 2013, indicates that the Oneworld transatlantic JV increased airfares of online flights by about 3%–4% in the behind-to-gateway markets. Previous studies, which emphasized the airfare reductions of codeshare flights in the connecting markets, may have overestimated the benefits to consumers from JVs. U.S. DOT can better protect consumers by evaluating plausible airfare increases in online flights in the behind-to-gateway markets when reviewing new applications for JVs.
Generalized Methodology to Develop Mechanistically Informed Asphalt Mixture Layer Coefficients for AASHTO 1993 Pavement Design Approach
Authors: Nemati Rasool , Dave Eshan V. , Sias Jo E.
Published: September 2021

This paper presents a generalized framework for determining mechanistically informed layer coefficients (a-values) for asphalt mixtures in the AASHTO empirical pavement design approach. The layer coefficients influence the layer thicknesses and consequently the structural capacity of pavements. Therefore, it is critical to determine reliable mechanistically informed a-values. A set of 18 commonly used asphalt mixtures in New Hampshire was selected for investigation including different types of hot mix and cold central plant recycled mixtures that are used as wearing, binder, and base course layers. Laboratory characterization was conducted using the complex modulus, semi-circular bend, and direct tension cyclic fatigue testing methods. The mixtures were evaluated using three performance index parameters: complex modulus rutting index parameter, rate-dependent cracking index parameter, and a new continuum damage parameter ([Formula: see text]). The measured field performance of wearing course mixtures in terms of International Roughness Index was used to back-calculate the in situ performance-based layer coefficients (aIRI-values). Using a normal distribution function, the results from performance testing were incorporated with the aIRI-values to develop mechanistically informed mix-specific layer coefficients. In addition, a typical layer coefficient at specific reliability levels for each mix category including hot mix wearing course, hot mix binder and base course as well as cold central plant recycled mix course are proposed for New Hampshire. The recommended a-values are 0.48 for hot mix wearing, 0.41 for hot mixed binder and base, and 0.28 for cold recycled base mixtures; these are approximately 25% higher than the currently used a-values in New Hampshire.