bluuebunny/crossref_metadata_2025 huggingface dataset:
Ok lá þar at óvilja hennar: A Reconsideration of Sexual Violence in the Old Norse World
Authors: Bell Jacob
Published: November 2021

Despite the popularized image of the raping and pillaging Viking warrior, the culture of sexual violence in Old Norse society has remained surprisingly understudied. This article uses skaldic verses, a literary genre produced in Iceland and Norway, mainly from the ninth through the fourteenth centuries, to suggest a reconsideration of sexual violence in the Old Norse world. It suggests that skaldic verses can help scholars discern a spatial and cultural geography of sexual violence against free men, women, and slaves, which suggests it was widespread and multidimensional and had ties to a pan-north Atlantic slave trade in the Viking Age.
Leveraging the Scaling Up Nutrition Movement to Operationalize Stunting Prevention Activities: Implementation Lessons From Rural Malawi
Authors: Kodish Stephen R. , Farhikhtah Arghanoon , Mlambo Trust , Hambayi Mutinta Nseluke , Jones Vanessa , Aburto Nancy J.
Published: November 2021

Background:

The rural district of Ntchisi is in the central region of Malawi. Among children aged 6 to 23 months, the stunting prevalence is 40% to 50%. To address this high prevalence, the World Food Programme, with cooperating partners, supported the Government of Malawi to implement an integrated stunting prevention program entitled The Right Foods at the Right Time from 2013 to 2018.

Objective:

To provide implementation lessons learned from systematic documentation of how the Scaling Up Nutrition (SUN) movement, combined with other international and national initiatives and policies, was translated into tailored programming.

Methods:

During program conception, early design, and implementation, this descriptive study systematically documented the process of translating SUN principles and government policies into an operational stunting prevention program in rural Malawi.

Results:

We identified 8 factors that contributed to successful translation of policy into program activities: (1) well-structured National SUN framework, (2) reliable coordination platforms and district ownership, (3) systematic and evidence-informed program design, (4) multiple forms of data used to inform program planning, (5) multisectoral implementation approaches to stunting prevention, (6) innovation in technology to improve overall program efficiency, (7) systematic collaboration among diverse stakeholders, and (8) strong public health nutrition capacity of program team members.

Conclusions:

Lessons from this nutrition program in Ntchisi, Malawi, provide one case illustrating how the SUN movement, government policies, and global evidence base can be operationalized into tailored programming for improving nutrition.
Further structural characterization of ovine forestomach matrix and multi-layered extracellular matrix composites for soft tissue repair
Authors: Smith Matthew J , Dempsey Sandi G , Veale Robert WF , Duston-Fursman Claudia G , Rayner Chloe A F , Javanapong Chettha , Gerneke Dane , Dowling Shane G , Bosque Brandon A , Karnik Tanvi , Jerram Michael J , Nagarajan Arun , Rajam Ravinder , Jowsey Alister , Cutajar Samuel , Mason Isaac , Stanley Roderick G , Campbell Andrew , Malmstrom Jenny , Miller Chris H , May Barnaby C H
Published: November 2021

Decellularized extracellular matrix (dECM)–based biomaterials are of great clinical utility in soft tissue repair applications due to their regenerative properties. Multi-layered dECM devices have been developed for clinical indications where additional thickness and biomechanical performance are required. However, traditional approaches to the fabrication of multi-layered dECM devices introduce additional laminating materials or chemical modifications of the dECM that may impair the biological functionality of the material. Using an established dECM biomaterial, ovine forestomach matrix, a novel method for the fabrication of multi-layered dECM constructs has been developed, where layers are bonded via a physical interlocking process without the need for additional bonding materials or detrimental chemical modification of the dECM. The versatility of the interlocking process has been demonstrated by incorporating a layer of hyaluronic acid to create a composite material with additional biological functionality. Interlocked composite devices including hyaluronic acid showed improved in vitro bioactivity and moisture retention properties.
Physical activity and exercise in peritoneal dialysis: International Society for Peritoneal Dialysis and the Global Renal Exercise Network practice recommendations
Authors: Bennett Paul N , Bohm Clara , Harasemiw Oksana , Brown Leanne , Gabrys Iwona , Jegatheesan Dev , Johnson David W , Lambert Kelly , Lightfoot Courtney J , MacRae Jennifer , Meade Anthony , Parker Kristen , Scholes-Robertson Nicole , Stewart Krista , Tarca Brett , Verdin Nancy , Wang Angela Yee-Moon , Warren Madeleine , West Mike , Zimmerman Deborah , Li Philip Kam-Tao , Thompson Stephanie
Published: November 2021

Life participation requiring physical activity and physical function is a key patient-reported outcome for people receiving peritoneal dialysis (PD). Clinician guidance is required from multidisciplinary sources regarding exercise and activity advice to address the specific needs of this group. From August 2020 through to June 2021, the Global Renal Exercise Network and the International Society for Peritoneal Dialysis reviewed the published literature and international clinical experience to develop a set of clinical practice points. A set of questions relevant to physical activity and exercise were developed from the perspective of a person receiving PD and were the basis for the practice point development. The GRADE framework was used to evaluate the quality of evidence and to guide clinical practice points. The review of the literature found sparse quality evidence, and thus the clinical practice points are generally based on the expert consensus of people receiving PD, PD exercise expert clinicians and experienced PD exercise researchers. Clinical practice points address timing of exercise and activity (post-catheter insertion, peritoneal space empty or full), the uptake of specific activities (work, sex, swimming, core exercise), potential adverse outcomes related to activity and exercise (exit site care, perspiration, cardiovascular compromise, fatigue, intra-abdominal pressure), the effect of exercise and activity on conditions of interest (mental health, obesity, frailty, low fitness) and exercise nutrition.
Delay margin comparison in a velocity-only versus headway-only connected vehicle model
Authors: Wang Duo , Ramírez Adrián , Sipahi Rifat
Published: November 2021

Two different connected vehicle models are considered: one based on only using velocity measurements and the other using only headway, where each model is affected by delays due to human reaction times and sensing and communication lines. The presence of delays is established between any two vehicles that are neighbors as determined by the underlying network topology. The main focus here is to put light into our understanding of how much of time delay can the equilibrium of these models tolerate before becoming unstable. To this end, we compute, using the parallel processing computational tool Delay Margin Finder (parDMF), the delay margin of the equilibrium dynamics and discuss design trade-offs. We report that delay margin in the headway-only model is much less sensitive against the presence/absence of links in the network and that this model can have larger delay margin when larger number of vehicles are capable of communicating with other vehicles in the platoon.
Does Stigma Moderate the Efficacy of Mental- and Behavioral-Health Interventions? Examining Individual and Contextual Sources of Treatment-Effect Heterogeneity
Authors: Hatzenbuehler Mark L. , Pachankis John E.
Published: November 2021

In this article, we argue that stigma may be an important, but heretofore underrecognized, source of heterogeneity in treatment effects of mental- and behavioral-health interventions. To support this hypothesis, we review recent evidence from randomized controlled trials and spatial meta-analyses suggesting that stigma may predict not only who responds more favorably to these health interventions (i.e., individuals with more stigma experiences), but also the social contexts that are more likely to undermine intervention effects (i.e., communities with greater structural stigma). By highlighting the potential role of personal and contextual stigma in shaping response to interventions, our review paves the way for additional research.
Analysis of Media Bias—Glenn Beck TV Shows: A Content Analysis
Authors: Ahmad Rizwan
Published: November 2021

This study provides an overview of the media’s role in shaping public discourse and belief through framing news stories in a biased perspective and setting an agenda that is in keeping with the interests of the corporate and institutional funders of the media apparatus. Support for such an analysis is provided by a literature review that covers many critical aspects of news framing, agenda setting and cultivation theory, especially with respect to the emergence of a new ‘network society’. The ‘content analysis’ approach is utilised to search for biased content via the use of coders and decoders in some 140 randomly selected sampled links of the ‘Glenn Beck’ show during the two periods of time from 1 January 2010 to 30 June 2010, and from 1 January 2011 to 30 June 2011, each of these periods consisting of 70 samples. The results ultimately show that the programme almost unilaterally provides supportive views of moral conservative values, and slight negative portrayals of Muslims. The programme presents critical views of President Obama and his policies, although the finding in opposing Obama’s policies is not statistically significant. The significance of these findings is discussed within the larger context of media bias and its influence on political reality, as well as public discourse and belief; although the study and hence, the findings suggesting ‘bias’ do not represent the entire media industry representing conservative values.
Bahraini uprising of 2011: The (No More) hidden political role of sports journalism
Authors: Rabea Ali
Published: November 2021

Two events have brought the social movement in Bahrain to light yet again: the temporary detention of the football player Hakeem Al-Araibi in Thailand for alleged ‘terrorist’ acts and the imprisonment of the activist Najah Yusuf because of her criticism of the hosting of a Formula One Grand Prix. This paper sheds light on the nexus between sports journalism and politics in Bahrain. It highlights the weaponizing of sports journalism during the first few weeks of the 2011 uprising to protect the regime. The coverage of the demonstrations is analysed to inspect how the 2011 uprising was reported on by the pro-regime sports newspapers. This paper argues that sports journalism played an unprecedented political role during the uprising when it was used by the regime as a weapon to confront the protests and in the process reinforce the regime's control over the country.
Anticoagulant rodenticide ingestion: Who will develop coagulopathy?
Authors: Tam Ka Wing , Chan Chi Keung , Liu Shan
Published: November 2021

Introduction:

Development of coagulopathy after anticoagulant rodenticide ingestion varies among patients. This study aimed to identify factors that were associated with coagulopathy after anticoagulant rodenticide ingestion.

Methods:

This was a retrospective cohort study, conducted in the Hong Kong Poison Information Centre. All patients who reported rodenticide exposure and presented to the Accident and Emergency Department from 1 January 2010 to 31 December 2019 were recruited. Coagulopathy was defined as International Normalized Ratio of 1.3 or above.

Results:

One hundred sixty‐nine patients were included in the final analysis. The median age was 44 years old. Forty‐nine patients developed coagulopathy (International Normalized Ratio ⩾1.3). Univariate analysis (at p < 0.05) showed that age (p = 0.003), ingestion of first‐generation anticoagulant rodenticide (p = 0.017), ingestion of more than one pack (p < 0.001), intentional ingestion (p = 0.002), hypoalbuminemia (p < 0.001), elevated alanine aminotransferase level (p = 0.041) and abnormal estimated glomerular filtration rate (p = 0.005) on presentation, and co‐ingestion with paracetamol (p = 0.018) were associated with coagulopathy after anticoagulant rodenticide ingestion. Among these, ingestion of more than one pack (p < 0.001; odds ratio = 19.8; 95% confidence interval = 6.78–65.7), ingestion of first‐generation anticoagulant rodenticide (p = 0.006; odds ratio = 5.2; 95% confidence interval = 1.96–15.2), hypoalbuminemia (p < 0.001; odds ratio = 22.4; 95% confidence interval = 6.17–99.0) and elevated alanine aminotransferase level on presentation (p = 0.039; odds ratio = 7.11; 95% confidence interval = 1.58–33.1) were statistically significant in the multivariate analysis.

Conclusion:

Ingestion of more than one pack and ingestion of first‐generation anticoagulant rodenticides were significantly associated with the development of coagulopathy after anticoagulant rodenticide ingestion. Patients who developed hypoalbuminemia or elevated alanine aminotransferase level as a result of anticoagulant rodenticide ingestion were also significantly associated with the development of coagulopathy.
The biopsychosocial model – history, controversy and Engel
Authors: Lugg William
Published: November 2021

Objective:

The biopsychosocial (BPS) model remains the predominant theoretical framework underpinning contemporary psychiatric training and practice. Like all models, it has its limitations and its critics. In light of recent censure, The purpose of this article was to (a) review key aspects of the history, development and contemporary utility of the BPS model and, (b) review key contributions of George Engel.

Conclusion:

An aetiological model for mental disorders that involves psychological, biological and sociocultural factors has existed since at least the 1940s. The term “biopsychosocial” was arguably first coined by Roy Grinker in 1952. Spurred on by his interest in systems theory, Engel expanded upon the model in 1977 and used it to hypothesise about the integration of mind and body. Despite its shortcomings, the BPS model remains relevant and useful.
Average 4-Year Outcomes of Distal Oblique First Metatarsal Osteotomy for Stage 1 to 3 Hallux Rigidus
Authors: Saur Maurise , Lucas y Hernandez Julien , Barouk Pierre , Bejarano-Pineda Lorena , Maynou Carlos , Laffenetre Olivier
Published: November 2021

Background:

Hallux rigidus is the second most frequent pathology of the first ray. Surgical options for degenerative metatarsophalangeal joint disease are either joint destructive or conservative procedures. The hypothesis was that oblique distal shortening osteotomy of the first metatarsal is an effective conservative technique for the management of stage 1 to 3 hallux rigidus.

Methods:

We conducted a retrospective cohort study of 87 feet with Coughlin and Shurnas’s stage 1-3 hallux rigidus, operated between 2009 and 2019. The cohort consisted in 72 patients (87 feet) with an average age of 57±9 (30/79) years; 22 of 87 (25.3%) feet had the first metatarsal surgery performed in isolation; 65 of 87 (74.7%) had concomitant forefoot procedures, including 31 of 87 (35.6%) with Akin phalangeal osteotomies and 34 of 87 (39.1%) with Moberg phalangeal osteotomies. We evaluated the American Orthopaedic Foot & Ankle Society (AOFAS) Scale, subjective satisfaction, joint amplitudes, shortening rate, and occurrence of postoperative complications with a mean follow-up of 51 months (16/134).

Results:

The AOFAS score increased from 54.2±11.3 (25/70) preoperatively to 92.2±7.8 (62/100) postoperatively ( P < .001). Patients reported excellent or good outcome in 95.4% of cases. The 40-point self-reported pain subscale score improved from 19.6 (± 10.0) to 37.4 (± 5.4), P < .001. The overall range of motion increased from 61±21 (20/110) degrees to 69±17 (35/120) degrees ( P < .001). The mean first metatarsal shortening rate (SRpo) was 9.6%. Neither the Coughlin grade, the metatarsal index, or the SRpo influenced the AOFAS score. At 6-month follow-up, 15 patients had transfer metatarsalgia compared with 5 at last follow-up without requiring another surgical procedure. The risk was not significantly different according to Coughlin's stage, preoperative metatarsal index, or SRpo.

Conclusion:

Oblique distal osteotomy of the first metatarsal for stage 1-3 hallux rigidus, often in combination with other first ray procedures, performed well during our follow-up time period, with a high subjective satisfaction rate and few complications.

Level of Evidence:

Level III, retrospective cohort study.
An Initial Investigation of the Joint Classification of Hypomania- and Neurodevelopmental Disorder-Relevant Dimensions Within the Hierarchical Taxonomy of Psychopathology
Authors: Stanton Kasey , Khoo Shereen , McDonnell Christina G. , Villalongo Andino Mara , Sturgeon Taylor , Aasen Laura
Published: November 2021

We examined hierarchical structural models of psychopathology in samples of (a) adults recruited online and screened based on psychopathology history ( N = 429) and (b) undergraduates ( N = 529) to inform classification of neurodevelopmental disorder (NDD)- and hypomania-relevant dimensions within the Hierarchical Taxonomy of Psychopathology (HiTOP). Results differed across samples in some ways, but converged to indicate that some NDD- and hypomania-relevant dimensions aligned closely with different HiTOP spectra. For example, some hypomania-relevant dimensions (e.g., affective lability) overlapped strongly with the internalizing spectrum, whereas others (e.g., self-perceived charisma) were reverse-indicators of detachment. Examination of cross-sectional and prospective correlates for emergent factors also was informative in some ways. This included NDD-relevant and disinhibited externalizing dimensions associating robustly with treatment seeking history and recent experiences of distress. These results provide initial insights into classifying NDD- and hypomania-relevant dimensions within the HiTOP and indicate a need for future research in this area.
Engaging in dialogue during collaborative writing: The role of affective, cognitive, and social engagement
Authors: Zhang Boya
Published: November 2021

Collaborative writing (CW) involves two or more students writing a single text together. Previous studies mainly focused on students’ cognitive engagement in CW and investigated their attention to various language-related problems during task interaction. However, little CW research to date has considered that engagement in language-related discussions can manifest from three dimensions: cognitive, social, and affective. Focusing on the multidimensional characteristics of engagement, this study investigated how Russian learners’ social and affective reactions influence their focus on language use while they completed a CW task. Drawing on Svalberg’s framework of engagement with language to identify the three dimensions of engagement, I conducted a mixed-method approach towards analysing the audio-recorded collaborative dialogues by three student pairs ( n = 6), along with a qualitative analysis of their responses to a five-point Likert scale questionnaire. The analyses showed that when learners were interactive and viewed the activity as useful, they noticed many linguistic problems and elaborated on them. In contrast, when learners demonstrated social disengagement and perceived disadvantages from CW, they were likely to withdraw their attention from resolving the language issues they encountered. These findings indicate the complex and dynamic nature of task engagement. They can provide second language (L2) teachers with an in-depth understanding of how to fully engage students in instructional activities to better foster their L2 learning.
‘Guided by the science’: (De)politicising the UK government’s response to the coronavirus crisis
Authors: Kettell Steven , Kerr Peter
Published: November 2021

This article sets out to examine the politicising and depoliticising effects of the various stories that were deployed by the UK government in its response to the coronavirus crisis during its daily press briefings over a 2-month period between 16 March and 16 May 2020. In doing so, we identify four key narratives: (1) unprecedented government activism; (2) working to plan; (3) national security, wartime unity and sacrifice; and (4) scientific guidance. Through a quantitative and qualitative study of the deployment of these narratives, we attempt to further recent theoretical insights on depoliticisation by noting that the COVID-19 crisis produced a particular type of crisis moment in which the government was forced to respond in ‘real time’ to a set of circumstances which were rapidly changing. As such, this made it much more difficult to control the various stories they wanted to tell and therefore find a coherent ‘anchor’ for their politicising and depoliticising strategies. This led to some deft discursive footwork as the government sought to pass the ball of responsibility between various groups of actors in order to rapidly and continually shift the balance between avoiding blame and taking credit.
Impact of surgical drain output monitoring on patient outcomes in hepatopancreaticobiliary surgery: A systematic review
Authors: Kowal Mikolaj , Bolton William , Van Duren Bernard , Burke Joshua , Jayne David
Published: November 2021

Background and objective:

Surgical drains are widely utilized in hepatopancreaticobiliary surgery to prevent intra-abdominal collections and identify postoperative complications. Surgical drain monitoring ranges from simple-output measurements to specific analysis for constituents such as amylase. This systematic review aimed to determine whether surgical drain monitoring can detect postoperative complications and impact on patient outcomes.

Methods:

A systematic review was performed, and the following databases searched between 02/03/20 and 26/04/20: MEDLINE, EMBASE, The Cochrane Library, and Clinicaltrials.gov. All studies describing surgical drain monitoring of output and content in adult patients undergoing hepatopancreaticobiliary surgery were considered. Other invasive methods of intra-abdominal sampling were excluded.

Results:

The search returned 403 articles. Following abstract review, 390 were excluded and 13 articles were included for full review. The studies were classified according to speciality and featured 11 pancreatic surgery and 2 hepatobiliary surgery studies with a total sample of 3262 patients. Postoperative monitoring of drain amylase detected pancreatic fistula formation and drain bilirubin testing facilitated bile leak detection. Both methods enabled early drain removal. Improved patient outcomes were observed through decreased incidence of postoperative complications (pancreatic fistulas, intra-abdominal infections, and surgical-site infections), length of stay, and mortality rate. Isolated monitoring of drain output did not confer any clinical benefits.

Conclusions:

Surgical drain monitoring has advantages in the postoperative care for selected patients undergoing hepatopancreaticobiliary surgery. Enhanced surgical drain monitoring involving the testing of drain amylase and bilirubin improves the detection of complications in the immediate postoperative period.
“Are you asking me or are you telling me?”: Expertise, evidence, and blame attribution in a post-game interview
Authors: Lindwall Oskar , Lynch Michael
Published: November 2021

This paper is an analysis of a video clip of an interview between a reporter and ice hockey player following a game in which the player was involved in a hard collision with a member of the opposing team. The paper explores blame attribution and how participants claim and disclaim expertise in a way that supports or undermines assertions to have correctly seen and assessed the actions shown on tape. Our analysis focuses on the video of the interview, and it also examines relevant video clips of the collision and various commentaries about the identities of the characters and their actions shown on the videos. In brief, the study is a third-order investigation of recorded-actions-under-analysis. It uses the videos and commentaries as “perspicuous phenomena” that illuminate and complicate how the members’ own action category analysis is bound up with issues of expertise, evidence, and blame.
Teaching historical literacies to digital learners via popular culture
Authors: Evans Rhiannon , Midford Sarah
Published: November 2021

We argue that students can understand an historical period by building on the foundations of their existing knowledge. Specifically, popular media can be used to develop students’ historical literacies – that is their ability to engage with past societies vastly different from their own. Our methodology takes inspiration from the ancient Romans’ own partial literacies and utilises pedagogy drawn from Classical Reception Studies, which examines how the ancient world has been subsequently reinvented in everything from poetry to cinema. While traditional methods of teaching Classics potentially alienate learners and entrench the discipline’s elitism, we advocate learning about the past from a point of familiarity. Harnessing familiar texts and platforms to teach history can engage non-traditional learners and develop their historical literacies by leveraging pre-existing digital literacies. Furthermore, digital pedagogy fosters in students a sense that they can valuably contribute to disciplinary knowledge by recontextualising ancient sources.
MiR-495 Inhibits Cisplatin Resistance and Angiogenesis in Esophageal Cancer by Targeting ATP7A
Authors: Li Zhuanghua , Li Shaowen , Wen Yongqin , Chen Jingtang , Liu Kejun , Jia Jun
Published: November 2021

Background: Cancer resistance to chemotherapy is closely associated with changes in transporter systems. In this study, we investigated the possible regulation of 1 copper ion transporter (ATP7A; ATPase copper transporting alpha) by microRNA miR-495 and its implications in cisplatin resistance and angiogenesis in esophageal cancer. Methods: MiR-495 and ATP7A mRNA expression in clinical tissue samples and 2 cancer cell lines (Eca-109 and TE1) were detected by quantitative real-time polymerase chain reaction. The levels of miR-495 and ATP7A expression in Eca-109 and TE1 cells were increased by transfection with miR-495 mimics and ATP7A-overexpression vectors. Cell proliferation, apoptosis, and angiogenesis were assessed by CCK-8, flow cytometry, and tube formation assays, respectively. The levels of TNF-α and VEGF in cell culture supernatants were detected by enzyme linked immunosorbent assay, and in situ expression of NLRP3 was measured by immunofluorescence. The binding of miR-495 to ATP7A sequences was verified by dual luciferase reporter assays. Results:ATP7A expression was significantly increased, while miR-495 expression was decreased in the cancer tissues of esophageal cancer patients. MiR-495 mimics decreased the proliferation and promoted the apoptosis of cisplatin-resistant Eca-109 and TE1 cells. Furthermore, tube formation by human umbilical vein endothelial cells, TNF-α and VEGF secretion, and the levels of MRP1, ABCG1, ABCA1, and NLRP3 expression in cisplatin-resistant Eca-109 and TE1 cells were all reduced by miR-495 mimics. MiR-495 was shown to directly bind to ATP7A gene sequences to repress ATP7A expression in Eca-109 and TE1 cells. ATP7A overexpression substantially abrogated the changes in proliferation, apoptosis, angiogenesis, and above-mentioned gene expression in cisplatin-resistant Eca-109 and TE1 cells. Conclusions: MiR-495 suppressed cisplatin resistance and angiogenesis in esophageal cancer cells by targeting ATP7A gene expression.
CCNB1 promotes the development of hepatocellular carcinoma by mediating DNA replication in the cell cycle
Authors: Rong Min-Hua , Li Jian-Di , Zhong Lu-Yang , Huang Yu-Zhen , Chen Juan , Xie Li-Yuan , Qin Rong-Xing , He Xiao-Lian , Zhu Zhan-Hui , Huang Su-Ning , Zhou Xian-Guo
Published: November 2021

In our studies, cyclin B1 ( CCNB1) mRNA and protein were overexpressed in hepatocellular carcinoma (HCC) tissues compared with non-HCC tissues. Moreover, CCNB1 was overexpressed in the serum of HCC patients. The expression of CCNB1 was associated with several crucial clinicopathologic characteristics, and the HCC patients with overexpressed CCNB1 had worse overall survival outcomes. In the screening of interactional genes, a total of 266 upregulated co-expression genes, which were positively associated with CCNB1, were selected from the datasets, and 67 downregulated co-expression genes, which were negatively associated with CCNB1, were identified. The key genes might be functionally enriched in DNA replication and the cell cycle pathways. CDC20, CCNA2, PLK1, and FTCD were selected for further research because they were highly connected in the protein-protein interaction networks. Upregulated CDC20, CCNA2, and PLK1 and downregulated FTCD might result in undesirable overall survival outcomes for HCC patients. The univariate Cox analysis results showed that CDC20 and PLK1 might be two independent risk factors, while FTCD might be protective in HCC. Therefore, CCNB1 may participate in the cell cycle of HCC by regulating DNA replication, and CCNB1 may provide a direction for the diagnosis of early-stage HCC and targeted HCC therapy.
A Strategy for the Seventies: Circular A-95 and US Regional Planning
Authors: Basmajian Carlton , David Nina
Published: November 2021

In 1982, President Ronald Reagan issued Executive Order 12372, revoking a relatively obscure publication issued by the Office of Management and Budget in 1969, Circular No. A-95. One of many policy changes that were part of a broad effort to rebalance how power was shared between the federal government, the states, and municipalities, Reagan’s pen stroke ended what for many planners had been a critical piece of urban policy during the 1970s. Part of President Lyndon Johnson’s 1960s Great Society programs, an era when federal assistance to state and local governments in support of domestic policy increased significantly, A-95 had established a coordination and review process that local governments receiving federal funding for planning development projects would be required to follow. The program was designed to force local governments to engage in more comprehensive regional coordination. For the next 12 years, almost every planner across the country, at some point or another, worked within the A-95 process. But researchers who examined A-95 during its short life struggled to produce solid evidence of its effectiveness. Absent a clear metric of the program’s success or failure, the history and legacy of the A-95 program has since been largely neglected. This paper explores the history of Circular A-95, a booklet issued by the US Office of Management and Budget to guide the implementation of the Intergovernmental Cooperation Act of 1968. We argue that the rules contained in the A-95 circular should be understood as an effort to create a framework for regional planning. Using primary documents and secondary literature, we conclude that the program deserves to be re-read as an important attempt to use federal power to establish a pragmatic national planning policy in the United States in the latter half of the 20th century.
Exploring the perceptions of dignity among patients and nurses in hospital and community settings: an integrative review
Authors: Stephen Ekpenyong Mandu , Nyashanu Mathew , Ossey-Nweze Chioma , Serrant Laura
Published: November 2021

Background

Patients have a right to be treated with dignity. However, reports have continually identified concerns regarding the quality of care and dignity in hospitals. Undignified care can have unfavourable impact on the patient’s recovery such as leading to depression and loss of will to live. The aim of this study was to explore dignity as perceived by patients and nurses within hospital and community environments.

Methods

An integrative review methodological approach was adopted. Nine databases including Medline, CINAHL plus with full text, Web of Science, Embase, Pubmed, Psycinfo, Scopus, Nursing and Allied Health Source, and Science Direct were systematically searched for relevant articles using a predetermined set of inclusion criteria. Articles were included if they were primary empirical studies, peer reviewed, published between 2008–2019, assessing patients’ or nurses’ perception of dignity outside the end-of-life context, conducted in one of the European countries and written in English. Included papers were analysed using constant comparative analysis. The preferred reporting system for systematic review and meta-analysis (Prisma) flow diagram was used for quality appraisal and review.

Results

Fourteen relevant articles were included in this review. Four overarching themes and 10 subthemes were identified as impacting on patient dignity. Overarching themes include autonomy, healthcare delivery factors, organisational factors and the meaning of dignity, whilst subthemes include dependence/independence, choice, staff attitudes, communication, privacy, structure of services, staff shortages, physical environment, respect and person-centred care.

Conclusion

There are a wide range of factors impacting on patient dignity. Adopting evidence-based interventions supported by adequate theoretical backing can help to enhance patient dignity in hospital and community settings.
Prioritizing the influencing factors of utaut-2 model toward mobile network service providers
Authors: Patharia Ishani , Pandey Anjana , Gupta Sanjay
Published: November 2021

Technological developments have a major impact on user behavior. The rapidly evolving communication system and technology have provided numerous choices for people. The ever-shifting changes in the generation of communication networks have posed challenges for mobile network service providers to attract and retain customers. This study aims to prioritize the determinants of the adoption of mobile network service providers using the unified theory of acceptance and use of technology (UTAUT-2). In this study, data were collected from 660 mobile phone users in Haryana, India. A fuzzy analytical hierarchy process (F-AHP) was applied to arrange the priority or rank the factors based on the significance of the factors in explaining the adoption of mobile network service providers. Results of the study reveal that efforts expectancy is the highest-ranked and prioritized factor for the adoption of mobile network service providers followed by performance expectancy and facilitating conditions. However, social influence emerged as the least important factor. The present study provides theoretical implications for future researchers by synthesizing and prioritizing the important factors affecting technology acceptance. The practical implications offer a clearer insight to marketers for developing focused pragmatic strategies to retain customer loyalty. The study has considered only UTAUT-2 model constructs and used the F-AHP technique. Other factors may be considered in future studies. Other priority analysis techniques can also be used such as ISM and MICMAC analysis for further study. The research has been conducted in Haryana, India, and therefore, it needs to be tested in other areas/countries for generalizability.

JEL Classification: O1, O2, O4
4-(Dimethylamino)pyridine as an Efficient Catalyst for One-Pot Synthesis of 1,4-Pyranonaphthoquinone Derivatives viaMicrowave-Assisted Sequential Three Component Reaction in Green Solvent
Authors: Thanh Nguyen Ha , Phuong Hoang Thi , Giang Le Nhat Thuy , Giang Nguyen Thi Quynh , Ha Nguyen Thi Thu , Anh Dang Thi Tuyet , Cuong Vu Duc , Van Tuyen Nguyen , Van Kiem Phan
Published: November 2021

Novel 1,4-pyranonaphthoquinone derivatives were successfully synthesized via the microwave-assisted three-component reaction of 1,4-naphthoquinone, malononitrile, and various arylaldehydes in ethanol in the presence of 4-(dimethylamino)pyridine (DMAP) as a catalyst, and subsequently evaluated in terms of their antimicrobial and antifungal activities. This synthetic procedure has the notable advantages of environmental friendliness, short reaction time, good yield, and convenient operation.
Family life and Chinese adults’ happiness across the life span
Authors: Xu Jiashu , Liu Airan
Published: November 2021

An individual's happiness is closely related to their family life as the family is the institution in which they spend most of their life. Capitalizing on data from the 2018 China Family Panel Studies, this study investigates the relationship between family economic standing (measured by household income and homeownership) and family processes (measured by marital status and childlessness), as well as children's characteristics (measured by gender composition of children and adult children's educational attainment and marital status), and happiness of Chinese adults. We take a life-course perspective and examine how such relationships vary across different life stages. We find that factors like household income and homeownership are positively related to happiness for people in general; that married adults are happier than those who are unmarried; childlessness results in decreased individual happiness in old age; adult children's educational attainment, measured by college degree (three-year and four-year) and above, improves parents’ happiness; while children's unmarried status makes parents less happy. These significant relationships also change across the life span.
Effect of Colostomy on Treatment Outcome in Fournier Gangrene: A Prospective Comparative Study
Authors: Mahmood Barakat A. , ElSayed Emad H. , Ali Sherif A.
Published: November 2021

Background and Aim: Value of colostomy in management of Fournier gangrene (FG) is a debatable issue. Almost all relevant studies are retrospective and included heterogeneous patients’ groups. The present prospective study aimed to evaluate the role of colostomy in management of FG affecting the perianal region in 2 well-matched FG groups. Patients and Methods: The present prospective comparative study included 30 patients with FG associated with extensive involvement of the perianal region. They comprised 15 patients subjected to colostomy and other 15 patients who refused to perform the procedure. Colostomy was performed after the first debridement. Outcome parameters in the present study included time to wound healing, length of hospital stay, and inhospital mortality. Results: Comparison between the studied groups regarding the preoperative characteristics revealed no statistically significant differences. Postoperatively, patients in the colostomy group had significantly fewer number of debridements (1.3 ± 0.5 vs 2.7 ± 1.2, P < .001), shorter hospital stay (9.5 ± 3.3 vs 29.9 ± 6.2 days, P < .001), and significantly shorter time to wound healing (16.5 ± 3.9 vs 42.9 ± 6.9 days, P < .001). Also, patients in the colostomy group had significantly lower rate of wound dehiscence, wound infection, and flap ischemia. However, the difference wasn’t statistically significant. Conclusions: Aggressive treatment of FG aided by colostomy after first debridement would result in better clinical outcome.
Differences in Lower Extremity Kinematics Between Collegiate and Youth Softball Pitchers
Authors: Downs Talmage Jessica , Gilliam Jessica , Chardhari Ajit , Oliver Gretchen D.
Published: November 2021

Background:

Softball pitching is a whole-body motion that utilizes the kinetic chain to transfer the large amounts of force generated by the lower extremity to the ball. Although the lower extremity is responsible for generating most of the force in softball pitching, limited research has investigated how lower extremity kinematics vary with age.

Purpose/Hypothesis:

The purpose of this study was to compare lower extremity kinematics between collegiate and youth softball pitchers. It was hypothesized that there would be significant lower extremity kinematic differences between age groups.

Study Design:

Descriptive laboratory study.

Methods:

Overall, 83 softball pitchers participated in the study: 40 youth and 43 collegiate players. Kinematic data were collected using an electromagnetic motion capture system. All participants threw 3 fastballs to a catcher for a strike at regulation distance. Owing to nonnormally distributed data, Mann-Whitney U tests were used to determine group differences at 5 events during the pitching motion. The alpha level was set a priori at .006.

Results:

Collegiate pitchers had significantly higher drive-knee extension angular velocity at the 3-o’clock position than youth pitchers (182.30 ± 145.44 vs –34.66 ± 219.66 rad/s; P < .001). Collegiate pitchers also had greater peak drive-knee flexion angle than youth pitchers at the top of the arm circle (37.98° ± 18.09° vs 25.38° ± 17.58°; P = .004), while youth pitchers had a significantly more anteriorly shifted center of mass than collegiate pitchers at the top of the arm circle (49.93% ± 5.09% vs 46.47% ± 6.44%; P = .003).

Conclusion:

The authors found increased drive-knee flexion angle and angular extension velocity in collegiate compared with youth pitchers, although it is unknown if these differences were due to lack of experience or strength. Athletes should work on improving drive-leg mechanics to develop optimal push-off performance.

Clinical Relevance:

This information can be applied to develop strength and conditioning programs for softball pitchers. Player performance may be improved through performing exercises to strengthen knee and hip extension musculature and learning to eccentrically load the drive leg to activate the stretch shortening cycle.
Associations Between Hearing and Cognitive Abilities From Childhood to Middle Age: The National Child Development Study 1958
Authors: Okely Judith A , Akeroyd Michael A , Deary Ian J
Published: November 2021

Previous cross-sectional findings indicate that hearing and cognitive abilities are positively correlated in childhood, adulthood, and older age. We used an unusually valuable longitudinal dataset from a single-year birth cohort study, the National Child Development Study 1958, to test how hearing and cognitive abilities relate to one another across the life course from childhood to middle age. Cognitive ability was assessed with a single test of general cognitive ability at age 11 years and again with multiple tests at age 50. Hearing ability was assessed, using a pure tone audiogram, in childhood at ages 11 and 16 and again at age 44. Associations between childhood and middle-age hearing and cognitive abilities were investigated using structural equation modelling. We found that higher cognitive ability was associated with better hearing (indicated by a lower score on the hearing ability variables); this association was apparent in childhood ( r  =  -0.120, p <0.001) and middle age ( r  =  -0.208, p <0.001). There was a reciprocal relationship between hearing and cognitive abilities over time: better hearing in childhood was weakly associated with a higher cognitive ability in middle age ( β  =  -0.076, p  =  0.001), and a higher cognitive ability in childhood was associated with better hearing in middle age ( β  =  -0.163, p <0.001). This latter, stronger effect was mediated by occupational and health variables in adulthood. Our results point to the discovery of a potentially life-long relationship between hearing and cognitive abilities and demonstrate how these variables may influence one another over time.
Nursing Development in Indonesia: Colonialism, After Independence and Nursing act
Authors: Gede Juanamasta I , Iblasi Abdulkareem S. , Aungsuroch Yupin , Yunibhand Jintana
Published: November 2021

Introduction

Stereotyping of nurses still occurs nowadays in Indonesia. Society and healthcare think nursing is a doctor helper service. The public image of a nurse as a doctor's helper is hard to erase. Thus, the nursing development in Indonesia needs to be explored in describing the stereotyping and the nursing conditions in the current situation.

Methods

The study used a narrative review with 45 sources analyzed and extracted.

Results

Nursing education has been developed since colonialism. The first time the Netherland Indies built the hospital and they used Babu or a helper as a nurse. The result showed it had a negative impact, which showed as they started to train nurses. They trained male nurses to be Mantri nurses as hulpgeneesheeren (ancillary doctors). After independence, the project HOPE influenced the development of nursing in Indonesia. Indonesian nurses focused on technical aspects and added the nursing process to the education curricula in 1986. However, nurses’ practice culture did not change for a long time because of a lack of research and literature being evaluated during 1990–2010. Indonesia nursing started to increase the education, practice, and research afterward, with specifically the declaration of the Indonesian Nursing Act. It brought nurses into the professionalism of healthcare which the Indonesian government recognized. Then, nurses have faced new problems, including practice and education gaps.

Conclusion

The development of nurses will increase autonomy and dignity. Increasing education curricula, practice competency, and research impact will change the perspective of society with the support of recognition and education from the nursing organization. In addition, the nursing organization has an essential role in nursing development in each country.
Becoming WestConnex – Becoming Sydney: Object-oriented politics, contested storylines and the multi-scalar imaginaries of building a motorway network in Sydney, Australia
Authors: Haughton Graham , McManus Phil
Published: November 2021

Drawing on and developing literatures on automobilities, vertical urbanisms and the use of storylines to understand mega transport projects, we imagine infrastructure as a shifting assemblage of actors, storylines and material objects and practices. In the case of motorway building, this requires an understanding of how competing storylines about how both the infrastructure itself and the city it is located in are mobilised and politicised across diverse local geographies and multiple scales as the process proceeds. Our case study focuses on WestConnex, a 33 km motorway being built in Sydney, Australia. Similar to other major transport infrastructure projects, WestConnex morphed over time, growing in ambition, budget, complexity, debate and by enrolling new actors.
Revisiting Globalization Through Dalit Women Perspective
Authors: Sandhu Simran
Published: November 2021

The relation of globalization with social and economic empowerment of Dalit women is a highly contested issue especially when they continue to be victims of discrimination on the basis of their caste, class and gender. One of the major innovations of globalization in India is the microcredit loans and Self-Help Groups (SHGs) that were formed with the aim of increasing the financial independence of Dalit and poor Indian women. Although increasing number of women participate in SHGs, I argue that it is the Dalit women who do not receive their adequate benefits due to the existing division between Dalit and non-Dalit women, the role of the intermediaries and the subordination that is inflicted upon them by Dalit men. Finally, this study concludes that it is only when reforms are built specifically targeting the plight of Dalit women, then they will bring a change in their social and economic status.