bluuebunny/crossref_metadata_2025 huggingface dataset:
Performance Investigation of a Proposed Flipped npn Microstructure Silicon Solar Cell Using TCAD Simulation
Authors: Salem Marwa S. , Zekry Abdelhalim , Shaker Ahmed , Abouelatta Mohamed , ElBanna Mohamed M. , Almurayziq Tariq S. , Ramadan Rabie A. , Alshammari Mohammad T.
Published: July 2022

This work aims at inspecting the device operation and performance of a novel flipped npn microstructure solar cell based on low-cost heavily doped silicon wafers. The flipped structure was designed to eliminate the shadowing effect as applied in the conventional silicon-based interdigitated back-contact cell (IBC). Due to the disappearance of the shadowing impact, the optical performance and short-circuit current density of the structure have been improved. Accordingly, the cell power conversion efficiency (PCE) has been improved in comparison to the conventional npn solar cell microstructure. A detailed analysis of the flipped npn structure was carried out in which we performed TCAD simulations for the electrical and optical performance of the flipped cell. Additionally, a comparison between the presented flipped microstructure and the conventional npn solar cell was accomplished. The PCE of the conventional npn structure was found to be 14.5%, while it was about 15% for the flipped structure when using the same cell physical parameters. Furthermore, the surface recombination velocity and base bulk lifetime, which are the most important recombination parameters, were studied to investigate their influence on the flipped microstructure performance. An efficiency of up to 16% could be reached when some design parameters were properly fine-tuned. Moreover, the impact of the different physical models on the performance of the proposed cell was studied, and it was revealed that band gap narrowing effect was the most significant factor limiting the open-circuit voltage. All the simulations accomplished in this analysis were carried out using the SILVACO TCAD process and device simulators.
Synthesis, Characterization, Hirshfeld Surface Analysis, Crystal Structure and Molecular Modeling Studies of 1-(4-(Methoxy(phenyl)methyl)-2-methylphenoxy)butan-2-one Derivative as a Novel α-Glucosidase Inhibitor
Authors: Shivanna Chandra , Patil Shashank M. , Mallikarjunaswamy C. , Ramu Ramith , Akhileshwari Prabhuswamy , Nagaraju Latha Rani , Sridhar Mandayam A. , Khanum Shaukath Ara , Ranganatha V. Lakshmi , Silina Ekaterina , Stupin Victor , Achar Raghu Ram
Published: July 2022

The crystal compound was synthesized and characterized using conventional analytical techniques. The compound C19H21O3 crystallizes in a monoclinic crystal system with the space group P21/c. The crystal structure is stabilized by C-H…O interactions. The structure is further reinforced by π-π interactions. During in vitro inhibition of α-glucosidase, the crystal compound exhibited a significant inhibition of the enzyme (IC50: 10.30 ± 0.25 µg/mL) in comparison with the control, acarbose (IC50: 12.00 ± 0.10 µg/mL). Molecular docking studies were carried out for the crystal compound with the α-glucosidase protein model, which demonstrated that the crystal molecule has a good binding affinity (−10.8 kcal/mol) compared with that of acarbose (−8.2 kcal/mol). The molecular dynamics simulations and binding free energy calculations depicted the stability of the crystal molecule throughout the simulation period (100 ns). Further, a Hirshfeld analysis was carried out in order to understand the packing pattern and intermolecular interactions. The energy difference between the frontier molecular orbitals (FMO) was 4.95 eV.
Somatostatin Receptor Targeted PET-Imaging for Diagnosis, Radiotherapy Planning and Theranostics of Meningiomas: A Systematic Review of the Literature
Authors: Filippi Luca , Palumbo Isabella , Bagni Oreste , Schillaci Orazio , Aristei Cynthia , Palumbo Barbara
Published: July 2022

The aims of the present systematic review are to: (1) assess the diagnostic performance of somatostatin receptor (SSR)targeted positron emission tomography (PET) with different tracers and devices in patients affected by meningiomas; and (2) to evaluate the theranostic applications of peptide receptor radionuclide therapy (PRRT) in meningiomas. A systematic literature search according to PRISMA criteria was made by using two main databases. Only studies published from 2011 up to March 2022 in the English language with ≥10 enrolled patients were selected. Following our research strategy, 17 studies were included for the assessment. Fourteen studies encompassed 534 patients, harboring 733 meningiomas, submitted to SSR-targeted PET/CT (n = 10) or PET/MRI (n = 4) for de novo diagnosis, recurrence detection, or radiation therapy (RT) planning (endpoint 1), while 3 studies included 69 patients with therapy-refractory meningiomas submitted to PRRT (endpoint 2). A relevant variation in methodology was registered among diagnostic studies, since only a minority of them reported histopathology as a reference standard. PET, especially when performed through PET/MRI, resulted particularly useful for the detection of meningiomas located in the skull base (SB) or next to the falx cerebri, significantly influencing RT planning. As far as it concerns PRRT studies, stable disease was obtained in the 66.6% of the treated patients, being grade 1–2 hematological toxicity the most common side effect. Of note, the wide range of the administered activities, the various utilized radiopharmaceuticals (90Y-DOTATOC and/or 177Lu-DOTATATE), the lack of dosimetric studies hamper a clear definition of PRRT potential on meningiomas’ management.
Federated Learning-Based Detection of Invasive Carcinoma of No Special Type with Histopathological Images
Authors: Agbley Bless Lord Y. , Li Jianping , Hossin Md Altab , Nneji Grace Ugochi , Jackson Jehoiada , Monday Happy Nkanta , James Edidiong Christopher
Published: July 2022

Invasive carcinoma of no special type (IC-NST) is known to be one of the most prevalent kinds of breast cancer, hence the growing research interest in studying automated systems that can detect the presence of breast tumors and appropriately classify them into subtypes. Machine learning (ML) and, more specifically, deep learning (DL) techniques have been used to approach this problem. However, such techniques usually require massive amounts of data to obtain competitive results. This requirement makes their application in specific areas such as health problematic as privacy concerns regarding the release of patients’ data publicly result in a limited number of publicly available datasets for the research community. This paper proposes an approach that leverages federated learning (FL) to securely train mathematical models over multiple clients with local IC-NST images partitioned from the breast histopathology image (BHI) dataset to obtain a global model. First, we used residual neural networks for automatic feature extraction. Then, we proposed a second network consisting of Gabor kernels to extract another set of features from the IC-NST dataset. After that, we performed a late fusion of the two sets of features and passed the output through a custom classifier. Experiments were conducted for the federated learning (FL) and centralized learning (CL) scenarios, and the results were compared. Competitive results were obtained, indicating the positive prospects of adopting FL for IC-NST detection. Additionally, fusing the Gabor features with the residual neural network features resulted in the best performance in terms of accuracy, F1 score, and area under the receiver operation curve (AUC-ROC). The models show good generalization by performing well on another domain dataset, the breast cancer histopathological (BreakHis) image dataset. Our method also outperformed other methods from the literature.
Diagnostic Yield of Xpert MTB/RIF Assay Using Bronchoalveolar Lavage Fluid in Detecting Mycobacterium tuberculosis among the Sputum-Scarce Suspected Pulmonary TB Patients
Authors: Uddin Mohammad Khaja Mafij , Ather Md. Fahim , Akter Sharmin , Nasrin Rumana , Rahman Tanjina , Kabir Sk Nazmul , Rahman S. M. Mazidur , Pouzol Stephane , Hoffmann Jonathan , Banu Sayera
Published: July 2022

Tuberculosis (TB) remains one of the leading causes of death worldwide and is caused by the single infectious agent Mycobacterium tuberculosis (Mtb). Although sputum is the most common specimen for pulmonary TB detection, some other respiratory specimens, such as bronchoalveolar lavage (BAL) fluid, gastric lavage (GL), and induced sputum (IS), are also collected from patients who are unable to deliver sputum. In this study, we aimed to evaluate the diagnostic performances of different test methods for TB diagnosis using BAL fluid specimens from sputum-scarce pulmonary TB patients. In this current study, a total of 210 BAL fluid specimens were collected and subjected to culture on Lowenstein–Jensen (L-J) medium, using an N-acetyl-L-cysteine-Sodium Hydroxide decontamination and digestion method, Xpert MTB/RIF (Xpert, Cepheid, Sunnyvale, CA, USA) assay, and acid-fast bacilli (AFB) microscopy with a Ziehl–Neelsen staining method for the detection of pulmonary TB. The sensitivity and specificity of these methods were then analyzed against the composite reference standard (CRS). Additionally, the receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of these assays. Among the 210 specimens, 39 (18.6%), 27 (12.8%), and 12 (5.7%) were found positive with Xpert assay, culture, and AFB microscopy, respectively. Considering the CRS, 42 (20%) were positive as the final diagnosis. The Xpert assay had a significantly higher sensitivity (92.9%, 95% CI: 80.5–98.5) compared to culture (64.3%, 95% CI: 48.0–78.4) and AFB microscopy (28.6%, 95% CI: 15.7–44.6) against the CRS. Additionally, the area under the ROC curve (AUC) for the Xpert assay, culture, and AFB microscopy accounted for 0.964, 0.821, and 0.655, respectively, when using CRS as the reference. In conclusion, our study findings demonstrated that the Xpert assay conferred a considerable diagnostic potential compared to other conventional methods for the diagnosis of pulmonary TB from BAL fluid specimens.
Gradient Learning under Tilted Empirical Risk Minimization
Authors: Liu Liyuan , Song Biqin , Pan Zhibin , Yang Chuanwu , Xiao Chi , Li Weifu
Published: July 2022

Gradient Learning (GL), aiming to estimate the gradient of target function, has attracted much attention in variable selection problems due to its mild structure requirements and wide applicability. Despite rapid progress, the majority of the existing GL works are based on the empirical risk minimization (ERM) principle, which may face the degraded performance under complex data environment, e.g., non-Gaussian noise. To alleviate this sensitiveness, we propose a new GL model with the help of the tilted ERM criterion, and establish its theoretical support from the function approximation viewpoint. Specifically, the operator approximation technique plays the crucial role in our analysis. To solve the proposed learning objective, a gradient descent method is proposed, and the convergence analysis is provided. Finally, simulated experimental results validate the effectiveness of our approach when the input variables are correlated.
Translanguaging as a Strategy for Supporting Multilingual Learners’ Social Emotional Learning
Authors: Song Juyoung , Howard Deborah , Olazabal-Arias Walny
Published: July 2022

In this study, two teachers of multilingual learners in the U.S. report case stories about how they implemented translanguaging approaches in support of their students’ social emotional learning. Translanguaging refers to bilinguals’ meaning-making process using their multilingual resources. In the first case story, Deborah created and utilized multilingual writing checklists in her 3rd grade classroom to encourage and support students’ multilingual writing practices. She enacted translanguaging as a collaborative space, which enabled students to shift their roles from learners to teachers, helping them to increase their confidence and collaboration. In the second case story, Walny applied translanguaging approaches to reading in his 9th grade English classroom. He utilized translanguaging to explain literary concepts, create a multilingual reading list, and send letters to families in students’ first languages, enacting translanguaging as a space for connecting the multilingual texts. His approaches enhanced his students’ engagement with the text, the teacher, and the peers. The results highlight the significance of teachers’ advocating for multilingual learners’ use of their entire linguistic repertoire for their academic success and personal growth, providing implications for language teacher education.
Achieving 100% Renewable and Self-Sufficient Electricity in Impoverished, Rural, Northern Climates: Case Studies from Upper Michigan, USA
Authors: Adesanya Adewale A. , Sommerfeldt Nelson , Pearce Joshua M.
Published: July 2022

The development of 100% renewable electricity (RE) systems play a pivotal role in ensuring climate stability. Many municipalities blessed with wealth, an educated and progressive citizenry, and large RE resources, have already reached 100% RE generation. Impoverished municipalities in unwelcoming environments both politically and climatically (e.g., northern latitudes with long, dark winter conditions) appear to be incapable of transitioning to renewables. This study challenges that widespread assumption by conducting a detailed technical and economic analysis for three representative municipalities in the Western Upper Peninsula of Michigan. Each municipality is simulated with their own hourly electricity demand and climate profiles using an electrical supply system based on local wind, solar, hydropower, and battery storage. Sensitivities are run on all economic and technical variables. Results show that transition to 100% RE is technically feasible and economically viable. In all baseline scenarios, the 100% RE systems produced a levelized cost of electricity up to 43% less than the centralized utility rates, which are predominantly fueled by gas and coal. Current policies, however, prevent such self-sufficient systems from being deployed, which are not only detrimental to the global environment, but also aggravate the economic depression of such regions. Potential energy savings advance the prohibitive energy justice principle.
Trajectory Prediction with Correction Mechanism for Connected and Autonomous Vehicles
Authors: Lv Pin , Liu Hongbiao , Xu Jia , Li Taoshen
Published: July 2022

Trajectory prediction of surrounding vehicles is a critical task for connected and autonomous vehicles (CAVs), helping them to realize potential dangers in the traffic environment and make the most appropriate decisions. In a practical traffic environment, vehicles may affect each other, and the trajectories may have multi-modality and uncertainty, which makes accurate trajectory prediction a challenge. In this paper, we propose an interactive network model based on long short-term memory (LSTM) and a convolutional neural network (CNN) with a trajectory correction mechanism, using our newly proposed probability forcing method. The model learns the interactions between vehicles and corrects their trajectories during the prediction process. The output is a multimodal distribution of predicted trajectories. In the experimental evaluation of the US-101 and I-80 Next-Generation Simulation (NGSIM) real highway datasets, our proposed method outperforms other contrast methods.
Sound Feedback for Social Distance: The Case for Public Interventions during a Pandemic
Authors: Primett William , Da Silva Hugo Plácido , Gamboa Hugo
Published: July 2022

Within the field of movement sensing and sound interaction research, multi-user systems have gradually gained interest as a means to facilitate an expressive non-verbal dialogue. When tied with studies grounded in psychology and choreographic theory, we consider the qualities of interaction that foster an elevated sense of social connectedness, non-contingent to occupying one’s personal space. Upon reflection of the newly adopted social distancing concept, we orchestrate a technological intervention, starting with interpersonal distance and sound at the core of interaction. Materialised as a set of sensory face-masks, a novel wearable system was developed and tested in the context of a live public performance from which we obtain the user’s individual perspectives and correlate this with patterns identified in the recorded data. We identify and discuss traits of the user’s behaviour that were accredited to the system’s influence and construct four fundamental design considerations for physically distanced sound interaction. The study concludes with essential technical reflections, accompanied by an adaptation for a pervasive sensory intervention that is finally deployed in an open public space.
Evolution and Climate Drivers of NDVI of Natural Vegetation during the Growing Season in the Arid Region of Northwest China
Authors: Wang Huaijun , Li Zhi , Niu Yun , Li Xinchuan , Cao Lei , Feng Ru , He Qiaoning , Pan Yingping
Published: July 2022

Vegetation plays an important role in linking water, atmosphere, and soil. The dynamic change in vegetation is an important indicator for the regulation of the terrestrial carbon balance and climate change. This study applied trend analysis, detrended correlation analysis, and the Hierarchical Partitioning Algorithm (HPA) to GIMMS NDVI3g data, meteorological data, and natural vegetation types for the period 1983 to 2015 to analyze the temporal and spatial changes in NDVI during the growing season and its driving factors in the arid region of northwestern China. The results showed that: (1) the growing season length (GSL) was delayed, with a regional trend of 8 d/33 a, due to a significant advancement in the start of the growing season (SOS, −7 d/33 a) and an insignificant delay to the end of growing season (EOS, 2 d/33 a). (2) The regional change in NDVI was mainly driven by temperature and precipitation, contributing to variations in NDVI of forest of 36% and 15%, respectively, and in the NDVI of grassland, of 35% and 21%, respectively. In particular, changes to forested land and medium-coverage grassland (Mgra) were closely related to temperature and precipitation, respectively. (3) The spatial distribution of the mean NDVI of forest was closely related with precipitation, temperature, and solar radiation, with these meteorological variables explaining 20%, 15%, and 10% of the variation in NDVI, respectively. Precipitation and solar radiation explained 29% and 17% of the variation in the NDVI of grassland, respectively. The study reveals the spatial–temporal evolution and driving mechanism of the NDVI of natural vegetation in the arid region of Northwest China, which can provide theoretical and data support for regional vegetation restoration and conservation.
Effect of Bergamot and Laoxianghuang Polysaccharides on Gut Microbiota Derived from Patients with Hyperlipidemia: An Integrative Analysis of Microbiome and Metabolome during In Vitro Fermentation
Authors: Zheng Yang , Wang Yi , Luo Donghui , Lin Lianzhu , Lu Xingyu , Gao Jie , Xiao Chuqiao , Zhao Mouming
Published: July 2022

The aim of this study was to investigate the effects of bergamot polysaccharide (BP) and Laoxianghuang polysaccharides (LPs, fermented bergamot) on the microbiome and metabolome during the in vitro fermentation of gut microbiota from patients with hyperlipidemia. Results indicated that both BP and LPs were able to increase the production of acetic acid, propionic acid, and butyric acid. However, only LPs could decrease the content of isobutyric acid and isovaleric acid, which are detrimental to gut health. A 16S rRNA analysis showed that both BP and LPs could reduce the proportion of Fusobacterium, whereas they increased the Bacteroides content in hyperlipidemia. Untargeted UPLC-MS/MS metabolomic profiling found six bio-markers that were significantly changed after BP and LPs intervention, and four of the down-regulated metabolites were long-chain fatty acids associated with vascular diseases. These findings provide new evidence that BP and LPs have the potential to regulate imbalances in the gut microbiota in patients with hyperlipidemia and ameliorate its metabolic abnormalities.
Investigating Possible Synergism in the Antioxidant and Antibacterial Actions of Honey and Propolis from the Greek Island of Samothrace through Their Combined Application
Authors: Postali Evdoxia , Peroukidou Panagiota , Giaouris Efstathios , Papachristoforou Alexandros
Published: July 2022

Several honeybee products are known for their functional properties, including important antioxidant and antimicrobial actions. The present study examines the antioxidant activity (AA), total polyphenolic content (TPC), and antibacterial action of honey and propolis samples collected from the Greek island of Samothrace, which were applied in vitro either individually or in combination in selected concentrations. To accomplish this, the 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity and the Folin–Ciocalteu assays were employed to determine the AA and TPC, respectively, while the antibacterial action was investigated against each one of four important pathogenic bacterial species causing foodborne diseases (i.e., Salmonella enterica, Yersinia enterocolitica, Staphylococcus aureus, and Listeria monocytogenes) using the agar well diffusion assay. Compared to honey, propolis presented significantly higher AA and TPC, while its combined application with honey (at ratios of 1:1, 3:1, and 1:3) did not increase these values. Concerning the antibacterial action, Y. enterocolitica was proven to be the most resistant of all the tested bacteria, with none of the samples being able to inhibit its growth. S. enterica was susceptible only to the honey samples, whereas L. monocytogenes only to the propolis samples. The growth of S. aureus was inhibited by both honey and propolis, with honey samples presenting significantly higher efficacy than those of propolis. Νo synergism in the antibacterial actions was observed against any of the tested pathogens. Results obtained increase our knowledge of some of the medicinal properties of honey and propolis and may contribute to their further exploitation for health promotion and/or food-related applications (e.g., as preservatives to delay the growth of pathogenic bacteria).
Characterization of Dysphagia Thickeners Using Texture Analysis—What Information Can Be Useful?
Authors: Baixauli Raquel , Bolivar-Prados Mireia , Ismael-Mohammed Kovan , Clavé Pere , Tárrega Amparo , Laguna Laura
Published: July 2022

Besides shear viscosity, other texture parameters (adhesiveness or cohesiveness) might be relevant for safe swallowing in people suffering from oropharyngeal dysphagia. Shear viscosity is assessed through protocols developed using a viscometer or a rheometer. In contrast, protocols and instruments (capillary break-up rheometer) to assess adhesiveness and cohesiveness are less common and much less developed. Other equipment such as texture analyzers can provide useful information on food properties. Here, we aimed to explore different texture analyzer settings (type of test, probe, and protocol) to characterize four commercial dysphagia thickeners at the shear viscosity levels recommended by manufacturers. Among the tests used (extrusion or penetration) with the different probes (disc, cone and shape holder, sphere, or cylinder), cone extrusion provided information about adhesivity, disc extrusion about sample cohesiveness, and sphere about penetration and sample elasticity. The test speeds used influenced the results, but only one speed is needed as the different speeds provided the same fluid information; for easiness, it is proposed to use 1 mm/s. Comparing the texture analyzer results with viscosity values obtained at different shears, the texture analyzer parameters reflected information that differ from shear viscosity. This information could be relevant for the therapeutic effect of thickening products and food characterization.
Alginate-Based Composites for Corneal Regeneration: The Optimization of a Biomaterial to Overcome Its Limits
Authors: Tarsitano Martine , Cristiano Maria Chiara , Fresta Massimo , Paolino Donatella , Rafaniello Concetta
Published: July 2022

For many years, corneal transplantation has been the first-choice treatment for irreversible damage affecting the anterior part of the eye. However, the low number of cornea donors and cases of graft rejection highlighted the need to replace donor corneas with new biomaterials. Tissue engineering plays a fundamental role in achieving this goal through challenging research into a construct that must reflect all the properties of the cornea that are essential to ensure correct vision. In this review, the anatomy and physiology of the cornea are described to point out the main roles of the corneal layers to be compensated and all the requirements expected from the material to be manufactured. Then, a deep investigation of alginate as a suitable alternative to donor tissue was conducted. Thanks to its adaptability, transparency and low immunogenicity, alginate has emerged as a promising candidate for the realization of bioengineered materials for corneal regeneration. Chemical modifications and the blending of alginate with other functional compounds allow the control of its mechanical, degradation and cell-proliferation features, enabling it to go beyond its limits, improving its functionality in the field of corneal tissue engineering and regenerative medicine.
Milk Protein-Based Nanohydrogels: Current Status and Applications
Authors: Kaur Manpreet , Bains Aarti , Chawla Prince , Yadav Rahul , Kumar Anil , Inbaraj Baskaran Stephen , Sridhar Kandi , Sharma Minaxi
Published: July 2022

Milk proteins are excellent biomaterials for the modification and formulation of food structures as they have good nutritional value; are biodegradable and biocompatible; are regarded as safe for human consumption; possess valuable physical, chemical, and biological functionalities. Hydrogels are three-dimensional, cross-linked networks of polymers capable of absorbing large amounts of water and biological fluids without dissolving and have attained great attraction from researchers due to their small size and high efficiency. Gelation is the primary technique used to synthesize milk protein nanohydrogels, whereas the denaturation, aggregation, and gelation of proteins are of specific significance toward assembling novel nanostructures such as nanohydrogels with various possible applications. These are synthesized by either chemical cross-linking achieved through covalent bonds or physical cross-linking via noncovalent bonds. Milk-protein-based gelling systems can play a variety of functions such as in food nutrition and health, food engineering and processing, and food safety. Therefore, this review highlights the method to prepare milk protein nanohydrogel and its diverse applications in the food industry.
Gelling Behavior of PAM/Phenolic Crosslinked Gel and Its Profile Control in a Low-Temperature and High-Salinity Reservoir
Authors: Ding Fei , Dai Caili , Sun Yongpeng , Zhao Guang , You Qing , Liu Yifei
Published: July 2022

Gel conformance control technology is widely used in moderate and high temperature reservoirs. However, there are few studies on shallow low-temperature and high-salinity reservoirs. The difficulties are that it is difficult to crosslink at low temperatures and with poor stability at high salt concentrations. Therefore, the PHRO gel was developed, which was composed of gelatinizing agent (polyacrylamide), crosslinking agents (hexamethylenetetramine and resorcinol) and crosslinking promoting agent (oxalic acid). The PHRO could form high-strength gels in both deionized water and high-concentration salinity solutions (NaCl, KCl, CaCl2 and MgCl2). The observation of the microstructure of PHRO gel shows that a strong “stem—leaf”-shaped three-dimensional network structure is formed in deionized water, and the network structure is still intact in high-concentration salt solution. The results show that PHRO has good salt resistance properties and is suitable for conformance control of low-temperature and high-salinity reservoirs.
Immediate Effects of Stabilization Exercises on Trunk Muscle Activity during Jump Header Shooting: A Pilot Study
Authors: Sekine Chie , Saisu Kazusa , Hirabayashi Ryo , Yokota Hirotake , Hayashi Haruna , Takabayashi Tomoya , Edama Mutsuaki
Published: July 2022

This study aimed to clarify trunk muscle activity during jump header shooting and examine the immediate effects of trunk stabilization exercises on trunk muscle activity. Nineteen males who had played soccer for over 5 years were assigned to either the trunk stabilization exercise group or the control group. Muscle activity during jump header shooting was measured before and after intervention. The intervention in the trunk stabilization exercise group was trunk muscle training, whereas that in the control group was sitting. The phases of jump header shooting and the effects of the interventions were compared. In pre-intervention measurements, the internal oblique activity during the push-off phase and early floating phase was significantly greater than that during the late floating phase (p < 0.01667). In pre-intervention measurements, the muscle activity of the internal oblique increased from the push-off phase, prior to the increase in muscle activity of the rectus abdominis and external oblique, whereas the muscle activity of all abdominal muscles increased immediately after take-off. The trunk stabilization exercise intervention decreased the muscle activity of the erector spinae (p < 0.05). There seems to be a certain activation sequence in the abdominals during jump header shooting, and a single application of stabilization exercises could possibly reduce the activation of the back muscles.
Augmented Rehabilitation Program for Patients 60 Years and Younger Following Total Hip Arthroplasty—Feasibility Study
Authors: Negm Ahmed M. , Yavarai Milad , Jhangri Gian S. , Haennel Robert , Jones C. Allyson
Published: July 2022

The purpose of this study is to examine the feasibility, safety and outcomes of a study comparing a 6-week post-operative rehabilitation program to usual care in patients ≤60 years undergoing elective unilateral total hip arthroplasty (THA). Methods: A cohort of 24 THA patients were recruited during their 6-week postoperative visit to their surgeons. The community-based rehabilitation program, which was designed to improve function and increase activity, consisted of 12 structured exercise classes on land and water over 6 weeks. Physical activity was assessed using a Sense Wear Pro Armband (SWA). Participants completed the Hip Osteoarthritis Outcome Score (HOOS) and THA satisfaction questionnaire before and immediately after the intervention. Results: 14 participants received the augmented rehabilitation, and 10 participants were in the control group. All except one in the intervention group completed at least 80% of the sessions. The intervention group took significantly more steps/day (mean difference = 2440 steps/day, 95% CI = 1678, 4712) (p < 0.05), at the follow-up compared to baseline. The intervention group had a higher mean change of number of weekly PA bouts than the control group. Within the intervention group, all HOOS subscales were significantly higher at the follow-up compared to baseline. Conclusion: Findings provided pragmatic insight regarding the intervention and assessments of implementing an augmented rehabilitation program for elective THA.
Ensuring the Voice of the Very Severely Affected Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patient Is Heard in Research—A Research Model
Authors: Baxter Helen
Published: July 2022

Most of the research about Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) has focused on ambulant patients who are able to attend clinics. It is estimated that 25% of people with ME/CFS are severely, or very severely, affected and are housebound or bedbound; some require tube feeding. Due to the severity of their illness, these patients have largely been excluded from research and are often described as ‘hard to reach.’ A questionnaire was devised to gather data about their experiences of accessing tube feeding. By making the necessary reasonable adjustments, such as direct outreach and the option to complete the questionnaire by telephone or texting, very severely affected patients were enabled to participate and provided invaluable contributions. This study aimed to act as a model for future researchers.
An Effective Algorithm to Analyze the Optokinetic Nystagmus Waveforms from a Low-Cost Eye Tracker
Authors: Hsu Wei-Yen , Cheng Ya-Wen , Tsai Chong-Bin
Published: July 2022

Objective: Most neurological diseases are usually accompanied by changes in the oculomotor nerve. Analysis of different types of eye movements will help provide important information in ophthalmology, neurology, and psychology. At present, many scholars use optokinetic nystagmus (OKN) to study the physiological phenomenon of eye movement. OKN is an involuntary eye movement induced by a large moving surrounding visual field. It consists of a slow pursuing eye movement, called “slow phase” (SP), and a fast re-fixating saccade eye movement, called “fast phase” (FP). Non-invasive video-oculography has been used increasingly in eye movement research. However, research-grade eye trackers are often expensive and less accessible to most researchers. Using a low-cost eye tracker to quantitatively measure OKN eye movement will facilitate the general application of eye movement research. Methods & Results: We design an analytical algorithm to quantitatively measure OKN eye movements on a low-cost eye tracker. Using simple conditional filtering, accurate FP positions can be obtained quickly. The high-precision FP recognition rate is of great help for the subsequent calculation of eye movement analysis parameters, such as mean slow phase velocity (MSPV), which is beneficial as a reference index for patients with strabismus and other eye diseases. Conclusions: Experimental results indicate that the proposed method achieves faster and better results than other approaches, and can provide an effective algorithm to calculate and analyze the FP position of OKN waveforms.
Immersive Photographic Environments as Interactive Repositories for Preservation, Data Collection and Dissemination of Cultural Assets
Authors: Antinozzi Sara , di Filippo Andrea , Musmeci Daniela
Published: July 2022

The proposed work deals with the generative process of high-resolution 360° spherical photographs for the creation of an information container in the form of a virtual tour for the immersive fruition of the archaeological area of Abellinum. The development of the tool aims at the promotion and dissemination of the research results obtained so far within the project “Abellinum. Piano per la conoscenza, la tutela e la valorizzazione dell’antico centro irpino”, as well as a first expeditious approach for the digitisation of an area that is still difficult to access. This procedure, born out of a health emergency but also an economic-social one, acts as a suitable and valid alternative to more time-consuming methodologies, imposing a reflection on the resources to be deployed in relation to the purposes of the cultural offer. After describing the technical approach enacted, the study of the virtual tour interface design and the basic functions adopted in this first phase are investigated, hinting at possible implementations. What emerges is a progressive transdisciplinary enhancement between academic and professional skills for the promotion and preservation of cultural heritage, with the development of new tools and the transformation of existing ones on the basis of a technological process that is in its full rise.
Use of a Biostimulant Obtained from Slaughterhouse Sludge in a Greenhouse Tomato Crop
Authors: Ávila-Pozo Paloma , Parrado Juan , Caballero Pablo , Tejada Manuel
Published: July 2022

Currently, the use of biostimulants is widespread in sustainable agriculture because they represent an alternative to chemical fertilizers. In this manuscript, we investigate the response of a greenhouse tomato crop grown in pots to a biostimulant obtained from slaughterhouse sludge applied continuously to the substrate under which the tomato crop was grown or applied directly via the foliar route. Two doses of biostimulant (0.7 and 1.4 g L−1), applied four times throughout the crop growth period (120 days), were used. During this period, the height of the plants, number of flowers and number of fruits obtained were measured. After 90 days of the growth period, the nutrient contents in leaves as well as the chlorophyll a and b contents were analyzed. For fruits, nutrient and lycopene contents were determined, and the equatorial diameter and average fresh and dry weight were measured. The results indicate a higher content of nutrients and chlorophyll a and b in the leaves of plants treated with the highest dose of biostimulant and applied continuously to the substrate. This higher content of photosynthesis pigments in the plant is possibly responsible for a greater absorption of N by the plant and, consequently, for better growth.
Certainty Factor Analyses and Spatiotemporal Characteristics of Landslide Evolution: Case Studies in the Chishan River Watershed in Taiwan
Authors: Wu Chunhung
Published: July 2022

The 1999 Chichi earthquake and Typhoon Morakot in 2009 caused two serious landslide events in the Chishan river watershed in southern Taiwan. In this study, certainty factor analysis was used to evaluate the effectiveness of landslide occurrence, and spatiotemporal hotspot analysis was used to explain the pattern and distribution of landslide hotspots. The Z-values from the Getis–Ord formula were used to assess the clustering strength of landslide evolution on different scales and with different landslide sizes in different time periods. The landslide-prone area had an elevation of 1000–1750 m, a slope of >40°, and hillslopes with N, NE, E, and SE aspects and was within 100 m of rivers. The main spatiotemporal hotspot patterns of landslide evolution during 1999–2017 were oscillating hotspots, intensifying hotspots, and persistent hotspots, and the three main hotspot patterns occupied 80.1–89.4% of all hotspot areas. The main spatiotemporal landslide hotspots were concentrated in the core landslide areas and the downslopes of riverbank landslide areas, especially in the upstream subwatersheds. The landslide clustered strength in the upstream watershed was 3.4 times larger than that in the Chishan river watershed, and that in large landslides was 2.4 and 6.6 times larger than those in medium and small landslides, respectively.
The Bugs in the Bags: The Risk Associated with the Introduction of Small Quantities of Fruit and Plants by Airline Passengers
Authors: Pace Roberta , Ascolese Roberta , Miele Fortuna , Russo Elia , Griffo Raffaele V. , Bernardo Umberto , Nugnes Francesco
Published: July 2022

Among European countries, Italy is the most exposed to the risk of biological invasions, principally for its numerous entry points (ports and airports) and for climatic conditions favorable for the acclimatization of several invasive species. Here it was assessed that the greatest threats to our agro-ecosystems come mainly from the passenger baggage in which a variety of fruits and vegetables are carried. From 2016 to 2021, large quantities of plant products were found in the luggage of passengers travelling from outside the EU and seized at the BCPs (border control posts) in the Campania region. Inspections and the following laboratory analyses were conducted on the plant material to assess the presence of exotic pests. Inspections led to several non-native species being recorded, and among the intercepted organisms, some should be considered “alarming”, such as Bactrocera dorsalis, Anastrepha obliqua, and Leucinodes africensis. Despite a well-organized border inspection system, travelers transporting infested material unknowingly contribute to increasing the risk of the introduction of exotic species. Given the current situation, it is necessary to impose stricter controls and greater attention, ensuring compliance with the requirements of the new phytosanitary regulations by the actors involved in the transport of plant material. Finally, it is essential to improve awareness through a phytosanitary campaign on plant health risks, especially for people wishing to transport fruits and vegetables in their luggage.
Exercise Training Effects on Circulating Endothelial and Progenitor Cells in Heart Failure
Authors: Kourek Christos , Briasoulis Alexandros , Zouganeli Virginia , Karatzanos Eleftherios , Nanas Serafim , Dimopoulos Stavros
Published: July 2022

Heart failure (HF) is a major public health issue worldwide with increased prevalence and a high number of hospitalizations. Patients with chronic HF and either reduced ejection fraction (HFrEF) or mildly reduced ejection fraction (HFmrEF) present vascular endothelial dysfunction and significantly decreased circulating levels of endothelial progenitor cells (EPCs). EPCs are bone marrow-derived cells involved in endothelium regeneration, homeostasis, and neovascularization. One of the unsolved issues in the field of EPCs is the lack of an established method of identification. The most widely approved method is the use of monoclonal antibodies and fluorescence-activated cell sorting (FACS) analysis via flow cytometry. The most frequently used markers are CD34, VEGFR-2, CD45, CD31, CD144, and CD146. Exercise training has demonstrated beneficial effects on EPCs by increasing their number in peripheral circulation and improving their functional capacities in patients with HFrEF or HFmrEF. There are two potential mechanisms of EPCs mobilization: shear stress and the hypoxic/ischemic stimulus. The combination of both leads to the release of EPCs in circulation promoting their repairment properties on the vascular endothelium barrier. EPCs are important therapeutic targets and one of the most promising fields in heart failure and, therefore, individualized exercise training programs should be developed in rehabilitation centers.
Risks and Benefits of Prophylactic Transfusion before Cholecystectomy in Sickle Cell Disease
Authors: Rambaud Elise , Ranque Brigitte , Tsiakyroudi Sofia , Joseph Laure , Bouly Nathalie , Douard Richard , François Anne , Pouchot Jacques , Arlet Jean-Benoît
Published: July 2022

Preoperative transfusion (PT) reduces acute postoperative vaso-occlusive events (VOE) in sickle cell disease (SCD), but exposes patients to alloimmunization, encouraging a recent trend towards transfusion sparing. The aim of this study was to investigate the benefit–risk ratio of PT before cholecystectomy on the occurrence of postoperative VOE. Adult SCD patients who underwent cholecystectomy between 2008 and 2019 in our center were included. Patients’ characteristics, collected retrospectively, were compared according to PT. A total of 79 patients were included, 66% of whom received PT. Gallbladder histopathology found chronic cholecystitis (97%) and gallstones (66%). Transfused patients underwent more urgent surgeries and had experienced more painful vaso-occlusive crises (VOC) in the month before surgery (p = 0.05). Four (8.5%) post-transfusion alloimmunizations occurred, and two of them caused a delayed hemolytic transfusion reaction (DHTR) (4.3%). The occurrence of postoperative VOE was similar between the groups (19.2% vs. 29.6%, p = 0.45). Though not statistically significant, a history of hospitalized VOC within 6 months prior to surgery seemed to be associated to postoperative VOE among non-transfused patients (75% vs. 31.6%, p = 0.10). PT before cholecystectomy exposes to risks of alloimmunization and DHTR that could be avoided in some patients. Recent VOCs appear to be associated with a higher risk of postoperative VOE and prompt the preemptive transfusion of these patients.
Proximal Median Nerve Compression in the Differential Diagnosis of Carpal Tunnel Syndrome
Authors: Löppönen Pekka , Hulkkonen Sina , Ryhänen Jorma
Published: July 2022

Carpal tunnel syndrome (CTS) is the most common median nerve compression neuropathy. Its symptoms and clinical presentation are well known. However, symptoms at median nerve distribution can also be caused by a proximal problem. Pronator syndrome (PS) and anterior interosseous nerve syndrome (AINS) with their typical characteristics have been thought to explain proximal median nerve problems. Still, the literature on proximal median nerve compressions (PMNCs) is conflicting, making this classic split too simple. This review clarifies that PMNCs should be understood as a spectrum of mild to severe nerve lesions along a branching median nerve, thus causing variable symptoms. Clear objective findings are not always present, and therefore, diagnosis should be based on a more thorough understanding of anatomy and clinical testing. Treatment should be planned according to each patient’s individual situation. To emphasize the complexity of causes and symptoms, PMNC should be named proximal median nerve syndrome.
Postacute Laryngeal Injuries and Dysfunctions in COVID-19 Patients: A Scoping Review
Authors: Lechien Jérôme R. , Hans Stéphane
Published: July 2022

Objective: To investigate post-acute laryngeal injuries and dysfunctions (PLID) in coronavirus disease 2019 (COVID-19) patients. Methods: Three independent investigators performed a systematic review of the literature studying PLID in patients with a history of COVID-19. The review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statement. Epidemiological, clinical, hospitalization features, laryngeal diseases, and voice outcomes were extracted from the included papers. Results: Eight papers met our inclusion criteria (393 patients) corresponding to five uncontrolled prospective and three retrospective studies. The most prevalent PLID were vocal fold dysmotility (65%), vocal fold edema (35%), muscle tension dysphonia (21%), and laryngopharyngeal reflux (24%). Posterior glottic stenosis (12%), granuloma (14%), and posterior glottic diastasis (12%) were the most common injuries. Most patients with PLID were obese and had a history of intensive care unit hospitalization, and orotracheal intubation. The delay between the discharge and the laryngology office consultation ranged from 51 to 122 days. The mean duration of intubation ranged from 10 to 34 days. Seventy-eight (49%) intubated patients were in the prone position. The proportion of patients requiring surgical treatment ranged from 39% to 70% (mean = 48%). There was an important heterogeneity between studies about inclusion, exclusion criteria, and outcomes. Conclusions: COVID-19 appeared to be associated with PLID, especially in patients with a history of intubation. However, future controlled studies are needed to evaluate if intubated COVID-19 patients reported more frequently PLID than patients who were intubated for other conditions.